@prefix rdf: . @prefix : . @prefix cl: . @prefix dc: . @prefix go: . @prefix hp: . @prefix pr: . @prefix obo: . @prefix owl: . @prefix xml: . @prefix xsd: . @prefix cito: . @prefix core: . @prefix foaf: . @prefix obda: . @prefix obo2: . @prefix pato: . @prefix rdfs: . @prefix skos: . @prefix swrl: . @prefix chebi: . @prefix swrla: . @prefix swrlb: . @prefix vocab: . @prefix chebi1: . @prefix chebi3: . @prefix chebi4: . @prefix chebi5: . @prefix hsapdv: . @prefix ubprop: . @prefix dcterms: . @prefix subsets: . @prefix oboInOwl: . @prefix caloha-reqs-vetted: . obo:BFO_0000002 obo:IAO_0000115 "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ; a owl:Class ; rdfs:label "continuant"@en ; rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000002 ; owl:onProperty obo:BFO_0000050 ] ; owl:disjointWith obo:BFO_0000003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000003 ] . obo:BFO_0000003 obo:IAO_0000115 "An entity that has temporal parts and that happens, unfolds or develops through time."@en ; a owl:Class ; rdfs:label "occurrent"@en ; rdfs:subClassOf [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000003 ; owl:onProperty obo:BFO_0000050 ] ; owl:disjointWith [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000002 ] . obo:BFO_0000004 obo:IAO_0000115 "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ; a owl:Class ; rdfs:comment "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en ; rdfs:label "independent continuant"@en ; rdfs:subClassOf obo:BFO_0000002, [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000004 ; owl:onProperty obo:BFO_0000050 ] ; owl:disjointWith obo:BFO_0000020, obo:BFO_0000031 . obo:BFO_0000006 a owl:Class ; rdfs:label "spatial region"@en ; rdfs:subClassOf obo:BFO_0000141 . obo:BFO_0000015 obo:IAO_0000115 "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ; a owl:Class ; rdfs:comment "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en ; rdfs:label "process"@en ; rdfs:subClassOf obo:BFO_0000003 . obo:BFO_0000016 a owl:Class ; rdfs:label "disposition"@en ; rdfs:subClassOf obo:BFO_0000017 ; owl:disjointWith obo:BFO_0000023 . obo:BFO_0000017 obo:IAO_0000115 "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ; a owl:Class ; rdfs:label "realizable entity"@en ; rdfs:subClassOf obo:BFO_0000020, [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000017 ; owl:onProperty obo:BFO_0000050 ] ; owl:disjointWith obo:BFO_0000019 . obo:BFO_0000019 a owl:Class ; rdfs:label "quality"@en ; rdfs:subClassOf obo:BFO_0000020, [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000019 ; owl:onProperty obo:BFO_0000050 ] . obo:BFO_0000020 obo:IAO_0000115 "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ; a owl:Class ; rdfs:comment "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en ; rdfs:label "specifically dependent continuant"@en ; rdfs:subClassOf obo:BFO_0000002, [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000020 ; owl:onProperty obo:BFO_0000050 ] ; owl:disjointWith obo:BFO_0000031 . obo:BFO_0000023 obo:IAO_0000115 "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts."@en ; a owl:Class ; rdfs:label "role"@en ; rdfs:subClassOf obo:BFO_0000017 . obo:BFO_0000031 obo:IAO_0000115 "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en ; a owl:Class ; rdfs:comment "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en ; rdfs:label "generically dependent continuant"@en ; rdfs:subClassOf obo:BFO_0000002, [ a owl:Restriction ; owl:allValuesFrom obo:BFO_0000031 ; owl:onProperty obo:BFO_0000050 ] . obo:BFO_0000034 a owl:Class ; rdfs:label "function"@en ; rdfs:subClassOf obo:BFO_0000016 . obo:BFO_0000040 obo:IAO_0000115 "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ; a owl:Class ; rdfs:label "material entity"@en ; rdfs:subClassOf obo:BFO_0000004 ; owl:disjointWith obo:BFO_0000141, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:BFO_0000141 ] . obo:BFO_0000050 obo:IAO_0000111 "is part of"@en ; obo:IAO_0000112 "my brain is part of my body (continuant parthood, two material entities)"@en, "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)"@en, "this day is part of this year (occurrent parthood)"@en ; obo:IAO_0000115 "a core relation that holds between a part and its whole"@en ; obo:IAO_0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'."""@en ; obo:IAO_0000118 "part_of"@en ; obo:RO_0001900 obo:RO_0001901 ; obo:RO_0040042 obo:BFO_0000002, obo:BFO_0000003, obo:BFO_0000004, obo:BFO_0000017, obo:BFO_0000019, obo:BFO_0000020, obo:BFO_0000031 ; oboInOwl:hasDbXref "BFO:0000050" ; oboInOwl:hasOBONamespace "quality", "uberon" ; oboInOwl:id "part_of" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_gp2term, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "part_of" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "part of", "part of"@en, "part_of" ; rdfs:seeAlso , , "http://www.obofoundry.org/ro/#OBO_REL:part_of", "https://wiki.geneontology.org/Part_of"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002131 ; owl:inverseOf obo:BFO_0000051 . obo:BFO_0000051 obo:IAO_0000111 "has part"@en ; obo:IAO_0000112 "my body has part my brain (continuant parthood, two material entities)"@en, "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)"@en, "this year has part this day (occurrent parthood)"@en ; obo:IAO_0000115 "a core relation that holds between a whole and its part"@en ; obo:IAO_0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'."""@en ; obo:IAO_0000118 "has_part"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "BFO:0000051" ; oboInOwl:hasOBONamespace "quality", "uberon" ; oboInOwl:id "has_part" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "has_part" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has part", "has part"@en, "has_part" ; rdfs:subPropertyOf obo:RO_0002131 . obo:BFO_0000056 a owl:ObjectProperty . obo:BFO_0000062 obo:IAO_0000111 "preceded by"@en ; obo:IAO_0000115 "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ; obo:IAO_0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other."@en ; obo:IAO_0000118 "is preceded by"@en, "preceded_by"@en ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" ; oboInOwl:hasDbXref "BFO:0000062" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "preceded_by" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "preceded_by" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "preceded by", "preceded by"@en ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002086 ; owl:inverseOf obo:BFO_0000063 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000062 ) . obo:BFO_0000063 obo:IAO_0000111 "precedes"@en ; obo:IAO_0000115 "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ; oboInOwl:hasDbXref "BFO:0000063" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "precedes" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "precedes" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "precedes", "precedes"@en ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002222 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000063 ) . obo:BFO_0000066 obo:IAO_0000111 "occurs in"@en ; obo:IAO_0000115 "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ; obo:IAO_0000118 "occurs_in"@en, "unfolds in"@en, "unfolds_in"@en ; oboInOwl:hasDbXref "BFO:0000066" ; oboInOwl:id "occurs_in" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "occurs_in" ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant" ; rdfs:domain obo:BFO_0000003 ; rdfs:isDefinedBy ; rdfs:label "occurs in", "occurs in"@en ; rdfs:range obo:BFO_0000004 ; rdfs:seeAlso "https://wiki.geneontology.org/Occurs_in"^^xsd:anyURI ; owl:inverseOf obo:BFO_0000067 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000066 ), (obo:BFO_0000066 obo:BFO_0000050 ) . obo:BFO_0000067 obo:IAO_0000111 "site of"@en ; obo:IAO_0000115 "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ; oboInOwl:hasDbXref "BFO:0000067" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "contains_process" ; oboInOwl:shorthand "contains_process" ; a owl:ObjectProperty ; rdfs:comment "Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant" ; rdfs:isDefinedBy ; rdfs:label "contains process", "contains process"@en . obo:BFO_0000141 a owl:Class ; rdfs:label "immaterial entity"@en ; rdfs:subClassOf obo:BFO_0000004 ; owl:disjointWith [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:BFO_0000040 ] . obo:BSPO_0000096 oboInOwl:hasDbXref "BSPO:0000096" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "anterior_to" ; oboInOwl:shorthand "anterior_to" ; a owl:ObjectProperty ; rdfs:label "anterior to" . obo:BSPO_0000097 oboInOwl:hasDbXref "BSPO:0000097" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "distal_to" ; oboInOwl:shorthand "distal_to" ; a owl:ObjectProperty ; rdfs:label "distal to" . obo:BSPO_0000098 oboInOwl:hasDbXref "BSPO:0000098" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dorsal_to" ; oboInOwl:shorthand "dorsal_to" ; a owl:ObjectProperty ; rdfs:label "dorsal to" . obo:BSPO_0000099 oboInOwl:hasDbXref "BSPO:0000099" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "posterior_to" ; oboInOwl:shorthand "posterior_to" ; a owl:ObjectProperty ; rdfs:label "posterior to" . obo:BSPO_0000100 oboInOwl:hasDbXref "BSPO:0000100" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "proximal_to" ; oboInOwl:shorthand "proximal_to" ; a owl:ObjectProperty ; rdfs:label "proximal to" . obo:BSPO_0000102 oboInOwl:hasDbXref "BSPO:0000102" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "ventral_to" ; oboInOwl:shorthand "ventral_to" ; a owl:ObjectProperty ; rdfs:label "ventral to" . obo:BSPO_0000107 oboInOwl:hasDbXref "BSPO:0000107" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "deep_to" ; oboInOwl:shorthand "deep_to" ; a owl:ObjectProperty ; rdfs:label "deep to" . obo:BSPO_0000108 oboInOwl:hasDbXref "BSPO:0000108" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "superficial_to" ; oboInOwl:shorthand "superficial_to" ; a owl:ObjectProperty ; rdfs:label "superficial to" . obo:BSPO_0000120 oboInOwl:hasDbXref "BSPO:0000120" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_left_side_of" ; oboInOwl:shorthand "in_left_side_of" ; a owl:ObjectProperty ; rdfs:label "in left side of" . obo:BSPO_0000121 oboInOwl:hasDbXref "BSPO:0000121" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_right_side_of" ; oboInOwl:shorthand "in_right_side_of" ; a owl:ObjectProperty ; rdfs:label "in right side of" . obo:BSPO_0000122 oboInOwl:hasDbXref "BSPO:0000122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_posterior_side_of" ; oboInOwl:shorthand "in_posterior_side_of" ; a owl:ObjectProperty ; rdfs:label "in posterior side of" . obo:BSPO_0000123 oboInOwl:hasDbXref "BSPO:0000123" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_anterior_side_of" ; oboInOwl:shorthand "in_anterior_side_of" ; a owl:ObjectProperty ; rdfs:label "in anterior side of" . obo:BSPO_0000124 oboInOwl:hasDbXref "BSPO:0000124" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_proximal_side_of" ; oboInOwl:shorthand "in_proximal_side_of" ; a owl:ObjectProperty ; rdfs:label "in proximal side of" . obo:BSPO_0000125 oboInOwl:hasDbXref "BSPO:0000125" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_distal_side_of" ; oboInOwl:shorthand "in_distal_side_of" ; a owl:ObjectProperty ; rdfs:label "in distal side of" . obo:BSPO_0000126 oboInOwl:hasDbXref "BSPO:0000126" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_lateral_side_of" ; oboInOwl:shorthand "in_lateral_side_of" ; a owl:ObjectProperty ; rdfs:label "in lateral side of" . obo:BSPO_0001101 oboInOwl:hasDbXref "BSPO:0001101" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_deep_part_of" ; oboInOwl:shorthand "in_deep_part_of" ; a owl:ObjectProperty ; rdfs:label "in deep part of" . obo:BSPO_0001106 oboInOwl:hasDbXref "BSPO:0001106" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "proximalmost_part_of" ; oboInOwl:shorthand "proximalmost_part_of" ; a owl:ObjectProperty ; rdfs:label "proximalmost part of" . obo:BSPO_0001107 oboInOwl:hasDbXref "BSPO:0001107" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "immediately_deep_to" ; oboInOwl:shorthand "immediately_deep_to" ; a owl:ObjectProperty ; rdfs:label "immediately deep to" . obo:BSPO_0001108 oboInOwl:hasDbXref "BSPO:0001108" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "distalmost_part_of" ; oboInOwl:shorthand "distalmost_part_of" ; a owl:ObjectProperty ; rdfs:label "distalmost part of" . obo:BSPO_0001113 oboInOwl:hasDbXref "BSPO:0001113" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "preaxialmost_part_of" ; oboInOwl:shorthand "preaxialmost_part_of" ; a owl:ObjectProperty ; rdfs:label "preaxialmost part of" . obo:BSPO_0001115 oboInOwl:hasDbXref "BSPO:0001115" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "postaxialmost_part_of" ; oboInOwl:shorthand "postaxialmost_part_of" ; a owl:ObjectProperty ; rdfs:label "postaxialmost part of" . obo:BSPO_0005001 oboInOwl:hasDbXref "BSPO:0005001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "intersects_midsagittal_plane_of" ; oboInOwl:shorthand "intersects_midsagittal_plane_of" ; a owl:ObjectProperty ; rdfs:label "intersects midsagittal plane of" . obo:BSPO_0015014 oboInOwl:hasDbXref "BSPO:0015014" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "immediately_superficial_to" ; oboInOwl:shorthand "immediately_superficial_to" ; a owl:ObjectProperty ; rdfs:label "immediately superficial to" . obo:BSPO_0015101 oboInOwl:hasDbXref "BSPO:0015101" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_dorsal_side_of" ; oboInOwl:shorthand "in_dorsal_side_of" ; a owl:ObjectProperty ; rdfs:label "in dorsal side of" . obo:BSPO_0015102 oboInOwl:hasDbXref "BSPO:0015102" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_ventral_side_of" ; oboInOwl:shorthand "in_ventral_side_of" ; a owl:ObjectProperty ; rdfs:label "in ventral side of" . obo:BSPO_0020001 oboInOwl:hasDbXref "BSPO:0020001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_central_side_of" ; oboInOwl:shorthand "in_central_side_of" ; a owl:ObjectProperty ; rdfs:label "in central side of" . obo:CHEBI_10545 obo:IAO_0000115 "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." ; chebi:charge "-1" ; chebi:mass "0.000548579903" ; chebi:monoisotopicmass "0.0" ; oboInOwl:hasDbXref "KEGG:C05359", "PMID:21614077", "Wikipedia:Electron" ; oboInOwl:hasExactSynonym "electron" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Elektron", "beta", "beta(-)", "beta-particle", "e", "e(-)", "e-", "negatron" ; oboInOwl:id "CHEBI:10545" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "electron" ; rdfs:subClassOf obo:CHEBI_36338 . obo:CHEBI_11596 obo:IAO_0000115 "A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of 2-hydroxyglutaric acid." ; chebi:charge "-2" ; chebi:formula "C5H6O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/p-2" ; chebi:inchikey "HWXBTNAVRSUOJR-UHFFFAOYSA-L" ; chebi:mass "146.09814" ; chebi:monoisotopicmass "146.02262" ; chebi:smiles "OC(CCC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:5736650", "MetaCyc:2-HYDROXYGLUTARIC_ACID", "Reaxys:5736650" ; oboInOwl:hasExactSynonym "2-hydroxypentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxyglutarate" ; oboInOwl:id "CHEBI:11596" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxyglutarate(2-)" ; rdfs:subClassOf obo:CHEBI_132941, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30921 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_36149 ] . obo:CHEBI_11955 obo:IAO_0000115 "The conjugate base of gamma-amino-beta-hydroxybutyric acid arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C4H8NO3" ; chebi:inchi "InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/p-1" ; chebi:inchikey "YQGDEPYYFWUPGO-UHFFFAOYSA-M" ; chebi:mass "118.11126" ; chebi:monoisotopicmass "118.05097" ; chebi:smiles "NCC(O)CC([O-])=O" ; oboInOwl:hasDbXref "CAS:352-21-6", "KEGG:C03678" ; oboInOwl:hasExactSynonym "4-Amino-3-hydroxybutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:11955" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-amino-3-hydroxybutanoate" ; rdfs:subClassOf obo:CHEBI_36059, obo:CHEBI_71666, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17968 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16080 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_57630 ] . obo:CHEBI_12109 chebi:charge "-1" ; chebi:formula "C5H8NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)/p-1" ; chebi:inchikey "ZGXJTSGNIOSYLO-UHFFFAOYSA-M" ; chebi:mass "130.12196" ; chebi:monoisotopicmass "130.05097" ; chebi:smiles "NCC(=O)CCC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3937762" ; oboInOwl:hasExactSynonym "5-amino-4-oxopentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:12109" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-aminolevulinate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_39150 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17549 ] . obo:CHEBI_12777 obo:IAO_0000115 "Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication." ; oboInOwl:hasDbXref "MetaCyc:Vitamin-A", "Wikipedia:Vitamin_A" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vitamin A vitamer", "vitamin A vitamers", "vitamin-A", "vitamins A" ; oboInOwl:id "CHEBI:12777" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin A" ; rdfs:subClassOf obo:CHEBI_26537, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24020 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ] . obo:CHEBI_131565 obo:IAO_0000115 "Any steroid substituted by a formyl group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "steroid aldehydes" ; oboInOwl:id "CHEBI:131565" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid aldehyde" ; rdfs:subClassOf obo:CHEBI_17478, obo:CHEBI_35341 . obo:CHEBI_131604 obo:IAO_0000115 "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Mycoplasma genitalium metabolites" ; oboInOwl:id "CHEBI:131604" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Mycoplasma genitalium metabolite" ; rdfs:subClassOf obo:CHEBI_76969 . obo:CHEBI_131619 obo:IAO_0000115 "A steroid compound with a structure based on a 27-carbon (cholestane) skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C27-steroids" ; oboInOwl:id "CHEBI:131619" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C27-steroid" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35516 ] . obo:CHEBI_131621 obo:IAO_0000115 "A steroid compound with a structure based on a 19-carbon (androstane) skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C19-steroids" ; oboInOwl:id "CHEBI:131621" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C19-steroid" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35509 ] . obo:CHEBI_131927 obo:IAO_0000115 "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acids and derivatives" ; oboInOwl:id "CHEBI:131927" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acids and O-substituted derivatives" ; rdfs:subClassOf obo:CHEBI_36586 . obo:CHEBI_132142 obo:IAO_0000115 "A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:132142" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1,4-naphthoquinones" ; rdfs:subClassOf obo:CHEBI_25481, obo:CHEBI_25830 . obo:CHEBI_132153 obo:IAO_0000115 "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "(C14H20NO11)n.H2O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hyaluronan", "hyaluronate polyanion" ; oboInOwl:id "CHEBI:132153" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hyaluronate" ; rdfs:subClassOf obo:CHEBI_61469, obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16336 ] . obo:CHEBI_132362 obo:IAO_0000115 "A citrate anion obtained by deprotonation of the three carboxy groups as well as the hydroxy group of citric acid." ; chebi:charge "-4" ; chebi:formula "C6H4O7" ; chebi:inchi "InChI=1S/C6H7O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h1-2H2,(H,7,8)(H,9,10)(H,11,12)/q-1/p-3" ; chebi:inchikey "KSXLKRAZYZIYCZ-UHFFFAOYSA-K" ; chebi:mass "188.092" ; chebi:monoisotopicmass "187.99790" ; chebi:smiles "C(=O)([O-])C(CC(=O)[O-])(CC(=O)[O-])[O-]" ; oboInOwl:hasDbXref "Chemspider:34552020" ; oboInOwl:hasExactSynonym "2-oxidopropane-1,2,3-tricarboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-oxido-1,2,3-propanetricarboxylate", "citric acid tetraanion" ; oboInOwl:id "CHEBI:132362" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrate(4-)" ; rdfs:subClassOf obo:CHEBI_133748, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16947 ] . obo:CHEBI_132938 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of ethylmalonic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ethylmalonate anion", "ethylmalonic acid anion" ; oboInOwl:id "CHEBI:132938" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ethylmalonate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_741548 ] . obo:CHEBI_132939 obo:IAO_0000115 "A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of ethylmalonic acid." ; chebi:charge "-2" ; chebi:formula "C5H6O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9)/p-2" ; chebi:inchikey "UKFXDFUAPNAMPJ-UHFFFAOYSA-L" ; chebi:mass "130.099" ; chebi:monoisotopicmass "130.02771" ; chebi:smiles "[O-]C(C(C(=O)[O-])CC)=O" ; oboInOwl:hasDbXref "Reaxys:3904851" ; oboInOwl:hasExactSynonym "ethylpropanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:132939" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ethylmalonate(2-)" ; rdfs:subClassOf obo:CHEBI_132938, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_741548 ] . obo:CHEBI_132941 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxyglutarate anion", "2-hydroxyglutaric acid anion" ; oboInOwl:id "CHEBI:132941" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxyglutarate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17084 ] . obo:CHEBI_132943 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:132943" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "aspartate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22660 ] . obo:CHEBI_132952 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of oxalic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ethanedioic acid anion", "ethanedioic acid anions", "oxalate anion", "oxalate anions", "oxalates", "oxalic acid anion", "oxalic acid anions" ; oboInOwl:id "CHEBI:132952" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxalate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16995 ] . obo:CHEBI_132954 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of sebacic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "decanedioic acid anion", "decanedioic acid anions", "sebacate anion", "sebacate anions", "sebacates", "sebacic acid anion", "sebacic acid anions" ; oboInOwl:id "CHEBI:132954" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sebacate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_41865 ] . obo:CHEBI_132961 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 3-methylsuccinic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-methylbutanedioic acid anion", "2-methylbutanedioic acid anions", "methylsuccinate anion", "methylsuccinates", "methylsuccinic acid anion", "methylsuccinic acid anions" ; oboInOwl:id "CHEBI:132961" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylsuccinate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_91315 ] . obo:CHEBI_132966 obo:IAO_0000115 "An N-acylglycinate obtained by deprotonation of the carboxy group of hippuric acid (N-benzoylglycine) and its derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-benzoylglycinates", "N-benzoylglycine anions" ; oboInOwl:id "CHEBI:132966" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hippurates" ; rdfs:subClassOf obo:CHEBI_57670 . obo:CHEBI_132970 obo:IAO_0000115 "A primary ammonium ion obtained by protonation of the amino group of 5-aminolevulinic acid." ; chebi:charge "+1" ; chebi:formula "C5H10NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)/p+1" ; chebi:inchikey "ZGXJTSGNIOSYLO-UHFFFAOYSA-O" ; chebi:mass "132.138" ; chebi:monoisotopicmass "132.06552" ; chebi:smiles "C(C(=O)C[NH3+])CC(=O)O" ; oboInOwl:hasExactSynonym "4-carboxy-2-oxobutan-1-aminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-aminolevulinic acid cation", "5-aminolevulinic acid(1+)" ; oboInOwl:id "CHEBI:132970" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-ammoniolevulinic acid" ; rdfs:subClassOf obo:CHEBI_65296, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17549 ] . obo:CHEBI_133251 obo:IAO_0000115 "A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of any 3-hydroxydicarboxylic acid." ; chebi:charge "-2" ; chebi:formula "C4H4O5R" ; chebi:mass "132.072" ; chebi:monoisotopicmass "132.00587" ; chebi:smiles "C(*C(CC(=O)[O-])O)([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxydicarboxylic acid dianion(2-)", "a 3-hydroxy dicarboxylic acid" ; oboInOwl:id "CHEBI:133251" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxydicarboxylate(2-)" ; rdfs:subClassOf obo:CHEBI_28965 . obo:CHEBI_133291 obo:IAO_0000115 "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid that contains no carbon-carbon double bonds." ; chebi:charge "-2" ; chebi:formula "C2O4R" ; chebi:mass "88.019" ; chebi:monoisotopicmass "87.97966" ; chebi:smiles "[O-]C(*C([O-])=O)=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a saturated dicarboxylic acid", "saturated dicarboxylate(2-)" ; oboInOwl:id "CHEBI:133291" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "saturated dicarboxylic acid dianion(2-)" ; rdfs:subClassOf obo:CHEBI_28965 . obo:CHEBI_133294 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of any oxo dicarboxylic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo dicarboxylic acid", "oxo dicarboxylic acid dianions" ; oboInOwl:id "CHEBI:133294" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo dicarboxylic acid dianion" ; rdfs:subClassOf obo:CHEBI_28965, obo:CHEBI_35903, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_36145 ] . obo:CHEBI_133580 obo:IAO_0000115 "A monocarboxylic acid anion that is the conjugate base of N-hexanoylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C8H14NO3" ; chebi:inchi "InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)/p-1" ; chebi:inchikey "UPCKIPHSXMXJOX-UHFFFAOYSA-M" ; chebi:mass "172.202" ; chebi:monoisotopicmass "172.09792" ; chebi:smiles "N(CC([O-])=O)C(CCCCC)=O" ; oboInOwl:hasExactSynonym "(hexanoylamino)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-caproylglycinate", "N-hexanoylglycine", "N-hexanoylglycine anion", "N-hexanoylglycine(1-)" ; oboInOwl:id "CHEBI:133580" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-hexanoylglycinate" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_57670, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_64390 ] . obo:CHEBI_133608 obo:IAO_0000115 "An alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 1-methylhistidine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C7H11N3O2" ; chebi:inchi "InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)" ; chebi:inchikey "BRMWTNUJHUMWMS-UHFFFAOYSA-N" ; chebi:mass "169.181" ; chebi:monoisotopicmass "169.08513" ; chebi:smiles "[O-]C(=O)C([NH3+])CC=1N=CN(C1)C" ; oboInOwl:hasExactSynonym "2-azaniumyl-3-(1-methyl-1H-imidazol-4-yl)propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:133608" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1-methylhistidine zwitterion" ; rdfs:subClassOf obo:CHEBI_78608, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84087 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_70958 ] . obo:CHEBI_133609 obo:IAO_0000115 "An alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 3-methylhistidine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C7H11N3O2" ; chebi:inchi "InChI=1S/C7H11N3O2/c1-10-4-9-3-5(10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)" ; chebi:inchikey "JDHILDINMRGULE-UHFFFAOYSA-N" ; chebi:mass "169.181" ; chebi:monoisotopicmass "169.08513" ; chebi:smiles "[O-]C(=O)C([NH3+])CC=1N(C=NC1)C" ; oboInOwl:hasExactSynonym "2-azaniumyl-3-(1-methyl-1H-imidazol-5-yl)propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:133609" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-methylhistidine zwitterion" ; rdfs:subClassOf obo:CHEBI_78608, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_70959 ] . obo:CHEBI_133610 obo:IAO_0000115 "A monocarboxylic acid anion that is the conjugate base of N-isobutyrylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C6H10NO3" ; chebi:inchi "InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)/p-1" ; chebi:inchikey "DCICDMMXFIELDF-UHFFFAOYSA-M" ; chebi:mass "144.149" ; chebi:monoisotopicmass "144.06662" ; chebi:smiles "C(CNC(=O)C(C)C)(=O)[O-]" ; oboInOwl:hasDbXref "HMDB:HMDB0000730" ; oboInOwl:hasExactSynonym "(2-methylpropanamido)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-(2-methylpropanoyl)glycinate", "N-isobutanoylglycinate", "isobutanoylglycinate", "isobutyrylglycinate" ; oboInOwl:id "CHEBI:133610" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-isobutyrylglycinate" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_57670, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84087 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_70979 ] . obo:CHEBI_133744 obo:IAO_0000115 "A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid." ; chebi:charge "-1" ; chebi:formula "C9H9O4" ; chebi:inchi "InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)/p-1" ; chebi:inchikey "QRMZSPFSDQBLIX-UHFFFAOYSA-M" ; chebi:mass "181.166" ; chebi:monoisotopicmass "181.05063" ; chebi:smiles "C1=C(C(=CC(=C1)CC([O-])=O)OC)O" ; oboInOwl:hasExactSynonym "(4-hydroxy-3-methoxyphenyl)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-methoxy-4-hydroxyphenylacetate" ; oboInOwl:id "CHEBI:133744" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homovanillate" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_545959 ] . obo:CHEBI_133748 obo:IAO_0000115 "A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "citrate", "citrate anions" ; oboInOwl:id "CHEBI:133748" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrate anion" ; rdfs:subClassOf obo:CHEBI_35753, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30769 ] . obo:CHEBI_134179 obo:IAO_0000115 "Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa." ; oboInOwl:hasDbXref "Wikipedia:Volatile_organic_compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "VOC", "VOCs", "volatile organic compounds" ; oboInOwl:id "CHEBI:134179" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "volatile organic compound" ; rdfs:subClassOf obo:CHEBI_72695 . obo:CHEBI_134249 obo:IAO_0000115 "An alkanesulfonate in which the carbon at position 1 is attached to R, which can represent hydrogens, a carbon chain, or other groups." ; chebi:charge "-1" ; chebi:formula "CH2O3SR" ; chebi:mass "94.091" ; chebi:monoisotopicmass "93.97246" ; chebi:smiles "C(S([O-])(=O)=O)*" ; oboInOwl:hasAlternativeId "CHEBI:22318" ; oboInOwl:hasDbXref "MetaCyc:Alkanesulfonates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkanesulfonate oxoanions", "alkanesulfonates", "an alkanesulfonate" ; oboInOwl:id "CHEBI:134249" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkanesulfonate oxoanion" ; rdfs:subClassOf obo:CHEBI_33554 . obo:CHEBI_134251 obo:IAO_0000115 "Any phenol carrying an additional methoxy substituent at the ortho-position." ; chebi:charge "0" ; chebi:formula "C7H4O2R4" ; chebi:mass "120.106" ; chebi:monoisotopicmass "120.02113" ; chebi:smiles "C1(=C(C(=C(C(=C1*)*)*)OC)O)*" ; oboInOwl:hasAlternativeId "CHEBI:13645" ; oboInOwl:hasDbXref "MetaCyc:Guaiacols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-hydroxy-2-methoxybenzenes", "2-methoxyphenol", "2-methoxyphenol derivative", "2-methoxyphenol derivatives", "2-methoxyphenols", "a guaiacol", "catechol monomethyl ether", "catechol monomethyl ethers", "o-methoxyphenol", "o-methoxyphenols", "ortho-methoxyphenol", "ortho-methoxyphenols" ; oboInOwl:id "CHEBI:134251" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "guaiacols" ; rdfs:subClassOf obo:CHEBI_25235, obo:CHEBI_33853 . obo:CHEBI_13643 obo:IAO_0000115 "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." ; oboInOwl:hasExactSynonym "glycols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Glykol" ; oboInOwl:id "CHEBI:13643" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycol" ; rdfs:subClassOf obo:CHEBI_23824 . obo:CHEBI_136849 obo:IAO_0000115 "An organic group derived from any 3-oxo-Delta(4)-steroid." ; chebi:charge "0" ; chebi:formula "C6H6O" ; chebi:mass "94.111" ; chebi:monoisotopicmass "94.04186" ; chebi:smiles "C1=C(C*)*C(CC1=O)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a 3-oxo-Delta4-steroid group" ; oboInOwl:id "CHEBI:136849" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-oxo-Delta(4)-steroid group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_136859 obo:IAO_0000115 "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." ; oboInOwl:hasDbXref "PMID:26449612" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pro-agents", "proagent", "proagents" ; oboInOwl:id "CHEBI:136859" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pro-agent" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_136889 obo:IAO_0000115 "Any steroid that has beta-configuration at position 5." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5beta steroids", "5beta-steroid", "5beta-steroids" ; oboInOwl:id "CHEBI:136889" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5beta steroid" ; rdfs:subClassOf obo:CHEBI_35341 . obo:CHEBI_137682 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methylhistidines" ; oboInOwl:id "CHEBI:137682" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "methylhistidine" ; rdfs:subClassOf obo:CHEBI_24599 . obo:CHEBI_137982 obo:IAO_0000115 "An organic cation obtained by protonation of the amino group of any tertiary amino compound." ; chebi:charge "+1" ; chebi:formula "HNR3" ; chebi:mass "15.015" ; chebi:monoisotopicmass "15.01090" ; chebi:smiles "[NH+](*)(*)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a tertiary amine", "tertiary amine(1+)", "tertiary ammonium ions" ; oboInOwl:id "CHEBI:137982" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tertiary ammonium ion" ; rdfs:subClassOf obo:CHEBI_25697, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_50996 ] . obo:CHEBI_138103 obo:IAO_0000115 "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." ; oboInOwl:hasDbXref "Wikipedia:Mineral_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic acids", "mineral acid", "mineral acids" ; oboInOwl:id "CHEBI:138103" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic acid" ; rdfs:subClassOf obo:CHEBI_39141 . obo:CHEBI_138131 obo:IAO_0000115 "Any sterol containing two double bonds between positions 5-6 and 7-8." ; chebi:charge "0" ; chebi:formula "C19H27OR" ; chebi:mass "271.418" ; chebi:monoisotopicmass "271.20619" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)=CC=C4C2(CCC(C4)O)C" ; oboInOwl:hasDbXref "MetaCyc:Delta5-Delta7-Steroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a Delta(5),Delta(7)-sterol" ; oboInOwl:id "CHEBI:138131" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Delta(5),Delta(7)-sterol" ; rdfs:subClassOf obo:CHEBI_15889 . obo:CHEBI_138141 obo:IAO_0000115 "Any C21-steroid carrying a hydroxy substituent at the 17alpha-position. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure." ; chebi:charge "0" ; chebi:formula "C21H36O" ; chebi:inchi "InChI=1S/C21H36O/c1-4-21(22)14-11-18-16-9-8-15-7-5-6-12-19(15,2)17(16)10-13-20(18,21)3/h15-18,22H,4-14H2,1-3H3/t15?,16?,17?,18?,19?,20?,21-/m1/s1" ; chebi:inchikey "JSIVWCLRCGAVHN-ILZKQPLKSA-N" ; chebi:mass "304.511" ; chebi:monoisotopicmass "304.27662" ; chebi:smiles "C1CCCC2C1(C3C(CC2)C4C(CC3)([C@](CC4)(CC)O)C)C" ; oboInOwl:hasDbXref "MetaCyc:17a-hydroxy-C21-steroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a 17alpha-hydroxy-C21-steroid" ; oboInOwl:id "CHEBI:138141" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "17alpha-hydroxy-C21-steroid" ; rdfs:subClassOf obo:CHEBI_35342, obo:CHEBI_61313 . obo:CHEBI_138366 obo:IAO_0000115 "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:138366" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bile acids" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_35350, obo:CHEBI_36078 . obo:CHEBI_13850 obo:IAO_0000115 "An apoprotein is a protein devoid of its characteristic prosthetic group or metal." ; oboInOwl:hasDbXref "KEGG:C16240" ; oboInOwl:hasExactSynonym "apoprotein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "apoproteins" ; oboInOwl:id "CHEBI:13850" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "apoprotein" ; rdfs:subClassOf obo:CHEBI_38560, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ] . obo:CHEBI_138675 obo:IAO_0000115 "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." ; oboInOwl:hasDbXref "Wikipedia:https://en.wikipedia.org/wiki/Gas" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gas molecular entities", "gaseous molecular entities", "gaseous molecular entity" ; oboInOwl:id "CHEBI:138675" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gas molecular entity" ; rdfs:subClassOf obo:CHEBI_33579 . obo:CHEBI_139120 obo:IAO_0000115 "Any carotenoid derivative with an beta-end group" ; chebi:charge "0" ; chebi:formula "C19H27R" ; chebi:mass "255.418" ; chebi:monoisotopicmass "255.21128" ; chebi:smiles "C1(=C(CCCC1(C)C)C)/C=C/C(=C/C=C/C(=C/*)/C)/C" ; oboInOwl:hasDbXref "MetaCyc:Carotenoid-beta-end-group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a carotenoid beta-end derivative" ; oboInOwl:id "CHEBI:139120" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "carotenoid beta-end derivative" ; rdfs:subClassOf obo:CHEBI_23044 . obo:CHEBI_13941 chebi:charge "-1" ; chebi:formula "CH2NO2" ; chebi:inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1" ; chebi:inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-M" ; chebi:mass "60.03212" ; chebi:monoisotopicmass "60.00910" ; chebi:smiles "NC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3903503", "CAS:302-11-4", "Gmelin:239604" ; oboInOwl:hasExactSynonym "carbamate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Carbamat", "Karbamat", "carbamate ion", "carbamic acid, ion(1-)" ; oboInOwl:id "CHEBI:13941" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbamate" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28616 ] . obo:CHEBI_139588 obo:IAO_0000115 "An alpha-oxyketone that has a hydroxy group as the alpha-oxy moiety." ; oboInOwl:hasDbXref "PMID:15326516", "PMID:19908854", "PMID:20382022", "PMID:23295224" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-hydroxy ketones", "alpha-hydroxy-ketone", "alpha-hydroxy-ketones", "alpha-hydroxyketone", "alpha-hydroxyketones" ; oboInOwl:id "CHEBI:139588" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-hydroxy ketone" ; rdfs:subClassOf obo:CHEBI_30879, obo:CHEBI_52396 . obo:CHEBI_139589 obo:IAO_0000115 "A carboxylic acid anion obtained by deprotonation of any retinoid carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "retinoate", "retinoates", "retinoid anions", "retinoid carboxylate anion", "retinoid carboxylate anions", "retinoid carboxylic acid anion", "retinoid carboxylic acid anions" ; oboInOwl:id "CHEBI:139589" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "retinoid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26537 ] . obo:CHEBI_139590 obo:IAO_0000115 "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group." ; chebi:charge "0" ; chebi:formula "C2H3O2R" ; chebi:mass "59.044" ; chebi:monoisotopicmass "59.01330" ; chebi:smiles "*C(C(O)([H])[H])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "primary alpha-hydroxy ketones", "primary alpha-hydroxy-ketone", "primary alpha-hydroxy-ketones", "primary alpha-hydroxyketone", "primary alpha-hydroxyketones" ; oboInOwl:id "CHEBI:139590" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary alpha-hydroxy ketone" ; rdfs:subClassOf obo:CHEBI_139588, obo:CHEBI_15734 . obo:CHEBI_139592 obo:IAO_0000115 "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups." ; chebi:charge "0" ; chebi:formula "C2HO2R3" ; chebi:mass "57.028" ; chebi:monoisotopicmass "56.99765" ; chebi:smiles "C(C(=O)*)(O)(*)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tertiary alpha-hydroxy ketones", "tertiary alpha-hydroxy-ketone", "tertiary alpha-hydroxy-ketones", "tertiary alpha-hydroxyketone", "tertiary alpha-hydroxyketones" ; oboInOwl:id "CHEBI:139592" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tertiary alpha-hydroxy ketone" ; rdfs:subClassOf obo:CHEBI_139588, obo:CHEBI_26878 . obo:CHEBI_140325 obo:IAO_0000115 "A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1)." ; chebi:charge "0" ; chebi:formula "CHNOR2" ; chebi:mass "43.025" ; chebi:monoisotopicmass "43.00581" ; chebi:smiles "N(C(*)=O)(*)[H]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "secondary carboxamides" ; oboInOwl:id "CHEBI:140325" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "secondary carboxamide" ; rdfs:subClassOf obo:CHEBI_37622 . obo:CHEBI_140601 obo:IAO_0000115 "Any saturated fatty acid containing 4 carbons." ; chebi:charge "0" ; chebi:formula "CHO2R" ; chebi:mass "45.017" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "*C(O)=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:140601" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid 4:0" ; rdfs:subClassOf obo:CHEBI_26666, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_78115 ] . obo:CHEBI_140785 chebi:charge "0" ; chebi:formula "C62H88CoN13O14PR" ; chebi:mass "1329.350" ; chebi:monoisotopicmass "1328.56433" ; chebi:smiles "[Co-3]1234(N5C6=C(C7=[N+]4C(=CC8=[N+]3C(=C(C9=[N+]2[C@@]([C@]5([C@@H]([C@@]6(C)CCC(=O)NC[C@H](OP(O[C@@H]%10[C@H](O[C@H](N%11C=[N+]1C%12=CC(=C(C=C%12%11)C)C)[C@@H]%10O)CO)(=O)[O-])C)CC(=O)N)[H])([C@]([C@@H]9CCC(N)=O)(CC(=O)N)C)C)C)[C@](C)([C@@H]8CCC(=O)N)CC(N)=O)C([C@@H]7CCC(=O)N)(C)C)C)*" ; oboInOwl:hasDbXref "MetaCyc:CPD-20938" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an R-cob(III)alamin" ; oboInOwl:id "CHEBI:140785" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "R-cob(III)alamin" ; rdfs:subClassOf obo:CHEBI_23333 . obo:CHEBI_142163 obo:IAO_0000115 "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." ; chebi:charge "0" ; chebi:formula "C7H6N2O" ; chebi:mass "134.136" ; chebi:monoisotopicmass "134.04801" ; chebi:smiles "C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:142163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "24G7 epitope" ; rdfs:subClassOf obo:CHEBI_24433, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ] . obo:CHEBI_142533 obo:IAO_0000115 "An organic group forming part of, and a proposed epitope within, globoside GM1." ; chebi:charge "0" ; chebi:formula "C18H30O15" ; chebi:mass "486.423" ; chebi:monoisotopicmass "486.15847" ; chebi:smiles "*[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@@H]([C@H](O[C@@H]3[C@@H]([C@@H](O)[C@H]([C@@H](CO)O3)O*)O)[C@@H]([C@H]2O)O)CO)[C@@H]([C@H]1O)O)CO" ; oboInOwl:hasDbXref "PMID:7691279" ; oboInOwl:hasExactSynonym "->4)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosylp-(1->4)-beta-D-glucopyranosyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl", "->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl group", "->4)-alpha-D-galactosyl-(1->4)-beta-D-galactosylp-(1->4)-beta-D-glucosyl" ; oboInOwl:id "CHEBI:142533" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "->4)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group" ; rdfs:subClassOf obo:CHEBI_33247, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ] . obo:CHEBI_142567 obo:IAO_0000115 "A trisaccharide beta-D-glucosyl group obtained by removal of the hydroxy group from the hemiacetal function of alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose. Part of, and the proposed epitope from, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide (globoside Gb3Cer; globotriosylceramide; CTH)." ; chebi:charge "0" ; chebi:formula "C18H31O15" ; chebi:mass "487.430" ; chebi:monoisotopicmass "487.16630" ; chebi:smiles "[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O)O)O)*" ; oboInOwl:hasDbXref "PMID:33643275", "PMID:7691279" ; oboInOwl:hasExactSynonym "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Gala1-4Galb1-4Glcb-yl", "Galalpha1-4Galbeta1-4Glcbeta-R", "Galalpha1-4Galbeta1-4Glcbeta-yl", "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc-yl", "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl" ; oboInOwl:id "CHEBI:142567" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group" ; rdfs:subClassOf obo:CHEBI_30697, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ], [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_68485 ] . obo:CHEBI_142590 obo:IAO_0000115 "Zwitterionic form of 3-aminoisobutyric acid arising from migration of a proton from the carboxy group to the amino group; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C4H9NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)" ; chebi:inchikey "QCHPKSFMDHPSNR-UHFFFAOYSA-N" ; chebi:mass "103.120" ; chebi:monoisotopicmass "103.06333" ; chebi:smiles "C(C(C)C[NH3+])([O-])=O" ; oboInOwl:hasExactSynonym "3-azaniumyl-2-methylpropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-aminoisobutanoate", "3-ammonio-2-methylpropanoate" ; oboInOwl:id "CHEBI:142590" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-aminoisobutanoic acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_49096 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_27389 ] . obo:CHEBI_142767 obo:IAO_0000115 "A beta-D-glucosyl group derived from the trisaccharide N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose. Implied reactive epitope within ganglioside GM3." ; chebi:charge "0" ; chebi:formula "C23H38NO18" ; chebi:mass "616.545" ; chebi:monoisotopicmass "616.20889" ; chebi:smiles "O([C@@H]1[C@H]([C@H](O[C@@H]2[C@H](O[C@@H](*)[C@@H]([C@H]2O)O)CO)O[C@@H]([C@@H]1O)CO)O)[C@]3(O[C@]([C@@H]([C@H](C3)O)NC(C)=O)([C@@H]([C@@H](CO)O)O)[H])C(O)=O" ; oboInOwl:hasDbXref "PMID:7534889" ; oboInOwl:hasExactSynonym "5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3'-sialyllactosyl", "Neu5Acalpha2-3Galbeta1-4Glcbeta-yl", "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl", "alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-yl" ; oboInOwl:id "CHEBI:142767" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-yl group" ; rdfs:subClassOf obo:CHEBI_30697, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ], [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_59226 ] . obo:CHEBI_14321 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" ; chebi:charge "-1" ; chebi:formula "C5H8NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1" ; chebi:inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-M" ; chebi:mass "146.12136" ; chebi:monoisotopicmass "146.04588" ; chebi:smiles "[NH3+]C(CCC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:327908" ; oboInOwl:hasExactSynonym "glutamate(1-)", "hydrogen glutamate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammoniopentanedioate", "glutamate", "glutamic acid monoanion" ; oboInOwl:id "CHEBI:14321" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamate(1-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29987 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18237 ] . obo:CHEBI_144637 obo:IAO_0000115 "The D-stereoisomer of 4-hydroxyproline." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3?,4-/m1/s1" ; chebi:inchikey "PMMYEEVYMWASQN-SRBOSORUSA-N" ; chebi:mass "131.131" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "[C@@H]1(CC(O)CN1)C(O)=O" ; oboInOwl:hasExactSynonym "4-hydroxy-D-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-4-hydroxypyrrolidine-2-carboxylic acid", "4-OH-D-Pro", "4-hydroxy-D-Pro" ; oboInOwl:id "CHEBI:144637" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxy-D-proline" ; rdfs:subClassOf obo:CHEBI_20392, obo:CHEBI_84185, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_18240 ] . obo:CHEBI_145810 obo:IAO_0000115 "A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies." ; oboInOwl:hasDbXref "PMID:12137720", "PMID:19251032", "PMID:25848166", "PMID:5941964", "PMID:6069707", "Wikipedia:Insulin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:145810" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "insulin" ; rdfs:subClassOf obo:CHEBI_15841, obo:CHEBI_24533, obo:CHEBI_25905 . obo:CHEBI_146306 obo:IAO_0000115 "A member of the class of carbohydrates and carbohydrate derivatives that is any oligosaccharide or polysaccharide in which the identity of one or more of the individual monosaccharide units, their connectivity (position of attachment) or the stereochemistry (alpha- or beta-) of one or more of the glycosidic linkages is not known." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "partially defined glycan", "partially defined glycans", "partially-defined glycans" ; oboInOwl:id "CHEBI:146306" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "partially-defined glycan" ; rdfs:subClassOf obo:CHEBI_78616 . obo:CHEBI_146500 obo:IAO_0000115 "An amino disaccharide that is 2-acetamido-2-deoxy-D-galactopyranose in which the hydroxy group at position 3 has been converted to the corresponding D-galactopyranoside. The stereochemistry at the anomeric position in each of the galactopyranose rings is not stated." ; chebi:charge "0" ; chebi:formula "C14H25NO11" ; chebi:inchi "InChI=1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13?,14?/m1/s1" ; chebi:inchikey "HMQPEDMEOBLSQB-PVSBWVJQSA-N" ; chebi:mass "383.350" ; chebi:monoisotopicmass "383.14276" ; chebi:smiles "O([C@@H]1[C@@H](NC(=O)C)C(O[C@@H]([C@@H]1O)CO)O)C2O[C@@H]([C@H](O)[C@H](O)[C@H]2O)CO" ; oboInOwl:hasDbXref "GlyGen:G01416HI", "GlyTouCan:G01416HI", "KEGG:G10100" ; oboInOwl:hasExactSynonym "2-acetamido-2-deoxy-3-O-D-galactopyranosyl-D-galactopyranose", "Gal(?1-3)GalNAc" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galacto-hexopyranose", "N-[(3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide", "WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a3-b1" ; oboInOwl:id "CHEBI:146500" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-Galp-(1->3)-D-GalpNAc" ; rdfs:subClassOf obo:CHEBI_146306, obo:CHEBI_22160, obo:CHEBI_22480, obo:CHEBI_22484 . obo:CHEBI_15318 obo:IAO_0000115 "A purine nucleobase found in humans and other organisms." ; chebi:charge "0" ; chebi:formula "C5H4N4O2" ; chebi:mass "152.111" ; chebi:monoisotopicmass "152.03343" ; oboInOwl:hasDbXref "ECMDB:ECMDB00292", "KNApSAcK:C00019660", "PMID:1557408", "PMID:24629268", "PMID:9007687", "YMDB:YMDB00263" ; oboInOwl:hasExactSynonym "xanthine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,6-dioxopurine", "2,6-dioxopurines", "xanthines" ; oboInOwl:id "CHEBI:15318" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "xanthine" ; rdfs:subClassOf obo:CHEBI_25810, obo:CHEBI_26386, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16235 ] . obo:CHEBI_15339 obo:IAO_0000115 "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." ; oboInOwl:hasAlternativeId "CHEBI:13699", "CHEBI:2377" ; oboInOwl:hasDbXref "KEGG:C00028", "KEGG:C16722" ; oboInOwl:hasExactSynonym "Acceptor" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "A", "Akzeptor", "Hydrogen-acceptor", "Oxidized donor", "accepteur" ; oboInOwl:id "CHEBI:15339" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acceptor" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_15356 obo:IAO_0000115 "A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3." ; chebi:charge "0" ; chebi:formula "C3H7NO2S" ; chebi:inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)" ; chebi:inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-N" ; chebi:mass "121.15922" ; chebi:monoisotopicmass "121.01975" ; chebi:smiles "NC(CS)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14061", "CHEBI:23508", "CHEBI:4050" ; oboInOwl:hasDbXref "Beilstein:1721406", "CAS:3374-22-9", "Gmelin:2933", "KEGG:C00736", "KNApSAcK:C00001351", "KNApSAcK:C00007323", "PMID:17439666", "PMID:25181601", "Reaxys:1721406", "Wikipedia:Cysteine" ; oboInOwl:hasExactSynonym "Cysteine", "cysteine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-3-mercaptopropionic acid", "2-amino-3-mercaptopropanoic acid", "2-amino-3-sulfanylpropanoic acid", "C", "Cys", "Cystein", "Hcys", "Zystein", "cisteina" ; oboInOwl:id "CHEBI:15356" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_26834, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50326 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32456 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32458 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35237 ] . obo:CHEBI_15361 obo:IAO_0000115 "A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H3O3" ; chebi:inchi "InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1" ; chebi:inchikey "LCTONWCANYUPML-UHFFFAOYSA-M" ; chebi:mass "87.05412" ; chebi:monoisotopicmass "87.00877" ; chebi:smiles "CC(=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14987", "CHEBI:26462" ; oboInOwl:hasDbXref "Beilstein:3587721", "CAS:57-60-3", "Gmelin:2502", "KEGG:C00022", "PMID:17190852", "PMID:21603897", "PMID:21823181", "PMID:21854850", "PMID:22006570", "PMID:22016370", "PMID:22215378", "PMID:22311625", "PMID:22451307", "PMID:22458763", "Reaxys:3587721", "UM-BBD_compID:c0159" ; oboInOwl:hasExactSynonym "2-oxopropanoate", "pyruvate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-oxopropanoate", "2-oxopropanoic acid, ion(1-)" ; oboInOwl:id "CHEBI:15361" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyruvate" ; rdfs:subClassOf obo:CHEBI_35179, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17272 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32816 ] . obo:CHEBI_15366 obo:IAO_0000115 "A simple monocarboxylic acid containing two carbons." ; chebi:charge "0" ; chebi:formula "C2H4O2" ; chebi:inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)" ; chebi:inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-N" ; chebi:mass "60.05200" ; chebi:monoisotopicmass "60.02113" ; chebi:smiles "CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:22169", "CHEBI:2387", "CHEBI:40486" ; oboInOwl:hasDbXref "Beilstein:506007", "CAS:64-19-7", "Drug_Central:4211", "Gmelin:1380", "HMDB:HMDB0000042", "KEGG:C00033", "KEGG:D00010", "KNApSAcK:C00001176", "LIPID_MAPS_instance:LMFA01010002", "MetaCyc:ACET", "PDBeChem:ACT", "PDBeChem:ACY", "PMID:12005138", "PMID:15107950", "PMID:16630552", "PMID:16774200", "PMID:17190852", "PMID:19416101", "PMID:19469536", "PMID:22153255", "PMID:22173419", "PPDB:1333", "Reaxys:506007", "Wikipedia:Acetic_acid" ; oboInOwl:hasExactSynonym "ACETIC ACID", "Acetic acid", "acetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "AcOH", "CH3-COOH", "CH3CO2H", "E 260", "E-260", "E260", "Essigsaeure", "Ethanoic acid", "Ethylic acid", "HOAc", "INS No. 260", "MeCO2H", "MeCOOH", "Methanecarboxylic acid", "acide acetique", "ethoic acid" ; oboInOwl:id "CHEBI:15366" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acetic acid" ; rdfs:subClassOf obo:CHEBI_25384, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48356 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_65256 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30089 ] . obo:CHEBI_15379 chebi:charge "0" ; chebi:formula "O2" ; chebi:inchi "InChI=1S/O2/c1-2" ; chebi:inchikey "MYMOFIZGZYHOMD-UHFFFAOYSA-N" ; chebi:mass "31.998" ; chebi:monoisotopicmass "31.98983" ; chebi:smiles "O=O" ; oboInOwl:hasAlternativeId "CHEBI:10745", "CHEBI:13416", "CHEBI:23833", "CHEBI:25366", "CHEBI:30491", "CHEBI:44742", "CHEBI:7860" ; oboInOwl:hasDbXref "CAS:7782-44-7", "Gmelin:485", "HMDB:HMDB0001377", "KEGG:C00007", "KEGG:D00003", "MetaCyc:OXYGEN-MOLECULE", "MolBase:750", "PDBeChem:OXY", "PMID:10906528", "PMID:16977326", "PMID:18210929", "PMID:18638417", "PMID:19840863", "PMID:7710549", "PMID:9463773", "Wikipedia:Oxygen" ; oboInOwl:hasExactSynonym "dioxygen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Disauerstoff", "E 948", "E-948", "E948", "O2", "OXYGEN MOLECULE", "Oxygen", "[OO]", "dioxygene", "molecular oxygen" ; oboInOwl:id "CHEBI:15379" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dioxygen" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_25362, obo:CHEBI_33263, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33284 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33893 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35472 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_63248 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77974 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29793 ] . obo:CHEBI_15428 obo:IAO_0000115 "The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain." ; chebi:charge "0" ; chebi:formula "C2H5NO2" ; chebi:inchi "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)" ; chebi:inchikey "DHMQDGOQFOQNFH-UHFFFAOYSA-N" ; chebi:mass "75.06664" ; chebi:monoisotopicmass "75.03203" ; chebi:smiles "NCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10792", "CHEBI:14344", "CHEBI:24368", "CHEBI:42964", "CHEBI:5460" ; oboInOwl:hasDbXref "Beilstein:635782", "CAS:56-40-6", "DrugBank:DB00145", "Drug_Central:1319", "ECMDB:ECMDB00123", "Gmelin:1808", "HMDB:HMDB0000123", "KEGG:C00037", "KEGG:D00011", "KNApSAcK:C00001361", "MetaCyc:GLY", "PDBeChem:GLY", "PMID:10930630", "PMID:11019925", "PMID:11174716", "PMID:11542461", "PMID:11806864", "PMID:12631515", "PMID:12754315", "PMID:12770151", "PMID:12921899", "PMID:15331688", "PMID:15388434", "PMID:15710237", "PMID:16105183", "PMID:16151895", "PMID:16214212", "PMID:16417482", "PMID:16444815", "PMID:16664855", "PMID:16901953", "PMID:16918424", "PMID:16986325", "PMID:16998855", "PMID:17154252", "PMID:17383967", "PMID:17582620", "PMID:17970719", "PMID:18079355", "PMID:18396796", "PMID:18440992", "PMID:18593588", "PMID:18816054", "PMID:18840508", "PMID:19028609", "PMID:19120667", "PMID:19449910", "PMID:19526731", "PMID:19544666", "PMID:19738917", "PMID:19916621", "PMID:19924257", "PMID:21751272", "PMID:22044190", "PMID:22079563", "PMID:22234938", "PMID:22264337", "PMID:22293292", "PMID:22401276", "PMID:22434786", "Reaxys:635782", "Wikipedia:Glycine", "YMDB:YMDB00016" ; oboInOwl:hasExactSynonym "GLYCINE", "Glycine", "aminoacetic acid", "glycine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aminoacetic acid", "Aminoessigsaeure", "G", "Gly", "Glycin", "Glycocoll", "Glykokoll", "Glyzin", "H2N-CH2-COOH", "Hgly", "Leimzucker", "aminoethanoic acid" ; oboInOwl:id "CHEBI:15428" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine" ; rdfs:subClassOf obo:CHEBI_26650, obo:CHEBI_33704, obo:CHEBI_83813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_62868 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64570 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64571 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32508 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32507 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57305 ] . obo:CHEBI_15440 obo:IAO_0000115 "A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration." ; chebi:charge "0" ; chebi:formula "C30H50" ; chebi:inchi "InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+" ; chebi:inchikey "YYGNTYWPHWGJRM-AAJYLUCBSA-N" ; chebi:mass "410.730" ; chebi:monoisotopicmass "410.39125" ; chebi:smiles "CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C" ; oboInOwl:hasAlternativeId "CHEBI:10795", "CHEBI:10843", "CHEBI:15104", "CHEBI:26746", "CHEBI:9245" ; oboInOwl:hasDbXref "Beilstein:1728920", "CAS:111-02-4", "HMDB:HMDB0000256", "KEGG:C00751", "KNApSAcK:C00003755", "LIPID_MAPS_instance:LMPR0106010002", "MetaCyc:SQUALENE", "PDBeChem:SQL", "PMID:16341241", "PMID:23625688", "PMID:24362891", "PMID:25286851", "PMID:25286853", "PMID:25987292", "Wikipedia:Squalene" ; oboInOwl:hasExactSynonym "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene", "Squalene", "squalene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene", "Spinacene", "Supraene" ; oboInOwl:id "CHEBI:15440" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "squalene" ; rdfs:subClassOf obo:CHEBI_35191, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_15551 obo:IAO_0000115 "Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins." ; chebi:charge "0" ; chebi:formula "C20H32O5" ; chebi:inchi "InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1" ; chebi:inchikey "XEYBRNLFEZDVAW-ARSRFYASSA-N" ; chebi:mass "352.471" ; chebi:monoisotopicmass "352.22497" ; chebi:smiles "CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1C\\C=C/CCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10910", "CHEBI:10911", "CHEBI:114125", "CHEBI:26323", "CHEBI:4625", "CHEBI:8512" ; oboInOwl:hasDbXref "Beilstein:2224724", "CAS:363-24-6", "DrugBank:DB00917", "Drug_Central:913", "FooDB:FDB022498", "HMDB:HMDB0001220", "KEGG:C00584", "KEGG:D00079", "LINCS:LSM-42919", "LIPID_MAPS_instance:LMFA03010003", "PDBeChem:P2E", "PMID:11279302", "PMID:12746806", "PMID:12859290", "PMID:14499495", "PMID:14535055", "PMID:14703707", "PMID:15542928", "PMID:15661432", "PMID:16405508", "PMID:16787416", "PMID:16978535", "PMID:20671299", "PMID:2403792", "PMID:24501112", "PMID:32898608", "PMID:33271839", "PMID:33559528", "PMID:33685091", "PMID:33715333", "PMID:33782420", "PMID:33811074", "PMID:33958485", "PMID:34065827", "PMID:34071686", "PMID:34102274", "PMID:6317292", "PMID:7224729", "PMID:74611", "PMID:7836930", "PMID:9276764", "Patent:DE2011969", "Patent:GB851827", "Patent:NL6505799", "Patent:US3598858", "Reaxys:2224724", "Wikipedia:Prostaglandin_E2" ; oboInOwl:hasExactSynonym "(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid", "Prostaglandin E2" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(15S)-prostaglandin E2", "(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid", "(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate", "(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate", "(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid", "(Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid", "Cervidil", "Cerviprime", "Cerviprost", "Dinoproston", "Enzaprost E", "Glandin-E2", "Minprositin E2", "Minprostin E2", "PGE2", "Prepidil", "Propess", "Prostarmon E", "Prostenone", "Prostin", "Prostin E2", "U 12062", "U-12,062", "U-12062", "dinoprostona", "dinoprostone", "dinoprostonum" ; oboInOwl:id "CHEBI:15551" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostaglandin E2" ; rdfs:subClassOf obo:CHEBI_26338, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_36063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_606564 ] . obo:CHEBI_15611 obo:IAO_0000115 "A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)" ; chebi:inchikey "FSYKKLYZXJSNPZ-UHFFFAOYSA-N" ; chebi:mass "89.09322" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "CNCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10876", "CHEBI:12609", "CHEBI:15065", "CHEBI:21765", "CHEBI:45381", "CHEBI:45442", "CHEBI:45531", "CHEBI:45614", "CHEBI:9029" ; oboInOwl:hasDbXref "Beilstein:1699442", "CAS:107-97-1", "Gmelin:2018", "HMDB:HMDB0000271", "KEGG:C00213", "MetaCyc:SARCOSINE", "PDBeChem:SAR", "PMID:11272730", "PMID:11850512", "PMID:15023571", "PMID:15331688", "PMID:16154544", "PMID:17095900", "PMID:17190852", "PMID:17901997", "PMID:19433577", "PMID:19577367", "PMID:19619564", "PMID:19944746", "Reaxys:1699442", "UM-BBD_compID:c0135", "Wikipedia:Sarcosine" ; oboInOwl:hasExactSynonym "SARCOSINE", "Sarcosine", "sarcosine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(methylamino)acetic acid", "(methylamino)ethanoic acid", "L-sarcosine", "MeGly", "N-Methylglycine", "N-methylaminoacetic acid", "Sar", "methylaminoacetic acid", "sarcosinic acid" ; oboInOwl:id "CHEBI:15611" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sarcosine" ; rdfs:subClassOf obo:CHEBI_21760, obo:CHEBI_21766, obo:CHEBI_66933, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64588 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64589 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_46915 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_46842 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57433 ] . obo:CHEBI_15676 obo:IAO_0000115 "An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen." ; chebi:charge "0" ; chebi:formula "C4H6N4O3" ; chebi:inchi "InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)" ; chebi:inchikey "POJWUDADGALRAB-UHFFFAOYSA-N" ; chebi:mass "158.11560" ; chebi:monoisotopicmass "158.04399" ; chebi:smiles "NC(=O)NC1NC(=O)NC1=O" ; oboInOwl:hasAlternativeId "CHEBI:13761", "CHEBI:22354", "CHEBI:2594" ; oboInOwl:hasDbXref "CAS:97-59-6", "Drug_Central:4268", "HMDB:HMDB0000462", "KEGG:C01551", "KEGG:D00121", "KNApSAcK:C00007468", "LINCS:LSM-5190", "MetaCyc:ALLANTOIN", "PMID:11157020", "PMID:14619112", "PMID:17190852", "Patent:US2158098", "Reaxys:83514", "Wikipedia:Allantoin" ; oboInOwl:hasExactSynonym "Allantoin", "N-(2,5-dioxoimidazolidin-4-yl)urea", "allantoin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2,5-Dioxo-4-imidazolidinyl)urea", "2,5-Dioxo-4-imidazolidinyl-urea", "4-ureido-2,5-imidazolidinedione", "5-Ureido-2,4-imidazolidindione", "5-Ureidohydantoin", "Glyoxyldiureide", "N-(2,5-Dioxo-4-imidazolidinyl)urea" ; oboInOwl:id "CHEBI:15676" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "allantoin" ; rdfs:subClassOf obo:CHEBI_24628, obo:CHEBI_47857, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_73336 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_27612 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_74345 ] . obo:CHEBI_15681 obo:IAO_0000115 "A sialodiosylceramide consisting of the trisaccharide alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide." ; chebi:charge "0" ; chebi:formula "C42H73N2O21R" ; chebi:mass "942.02980" ; chebi:monoisotopicmass "941.47058" ; chebi:smiles "[H][C@]1(O[C@@](C[C@H](O)[C@H]1NC(C)=O)(O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H](NC([*])=O)[C@H](O)\\C=C\\CCCCCCCCCCCCC)O[C@@H]2CO)[C@@H]1O)C(O)=O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:10959", "CHEBI:12288", "CHEBI:12580", "CHEBI:15680", "CHEBI:21147", "CHEBI:21623", "CHEBI:5227" ; oboInOwl:hasDbXref "KEGG:C04730", "KEGG:G00108", "LIPID_MAPS_instance:LMSP0601AJ00", "PMID:11093705", "PMID:11164910", "PMID:11534772", "PMID:12950986", "PMID:1371229", "PMID:1379980", "PMID:15102521", "PMID:15385432", "PMID:15546874", "PMID:1567198", "PMID:15939439", "PMID:16212238", "PMID:16341241", "PMID:16574813", "PMID:167132", "PMID:1724444", "PMID:19364317", "PMID:21149694", "PMID:2303428", "PMID:2448252", "PMID:2449247", "PMID:2714813", "PMID:2775195", "PMID:3392043", "PMID:3864442", "PMID:7534889", "PMID:7693874", "PMID:8448384", "PMID:8496625", "PMID:9375803" ; oboInOwl:hasExactSynonym "(2S,3R,4E)-2-(acylamino)-3-hydroxyoctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(Gal)1 (Glc)1 (Neu5Ac)1 (Cer)1", "(N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide", "(Neu5Ac)GM3", "GM3", "GM3 (NeuAc)", "Hematoside", "N-Acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide", "Neu5Ac-alpha2->3Gal-beta1->4Glc-beta1->1'Cer", "Neu5Acalpha2->3Galbeta1->4Glcbeta-Cer", "NeuAc-GM3", "NeuAcalpha2-3Galbeta1-4Glcbeta1-1'Cer", "NeuAcalpha2->3Galbeta1->4Glc-Cer", "alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide", "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide", "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramides", "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer", "alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer", "ganglioside GM3", "monosialoganglioside GM3" ; oboInOwl:id "CHEBI:15681" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide" ; rdfs:subClassOf obo:CHEBI_79209, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_142767 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59132 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_60065 ] . obo:CHEBI_15693 obo:IAO_0000115 "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." ; chebi:charge "0" ; chebi:formula "C2H4O2(CH2O)n" ; oboInOwl:hasAlternativeId "CHEBI:13755", "CHEBI:22305", "CHEBI:2561" ; oboInOwl:hasDbXref "KEGG:C01370", "Wikipedia:Aldose" ; oboInOwl:hasExactSynonym "Aldose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldoses", "an aldose" ; oboInOwl:id "CHEBI:15693" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldose" ; rdfs:subClassOf obo:CHEBI_35381 . obo:CHEBI_15705 obo:IAO_0000115 "Any alpha-amino acid having L-configuration at the alpha-carbon." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.05870" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "N[C@@H]([*])C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:13072", "CHEBI:13243", "CHEBI:13797", "CHEBI:21224", "CHEBI:6175" ; oboInOwl:hasDbXref "KEGG:C00151" ; oboInOwl:hasExactSynonym "L-alpha-amino acid", "L-alpha-amino acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-2-Amino acid", "L-Amino acid", "L-alpha-amino acids" ; oboInOwl:id "CHEBI:15705" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59814 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_59869 ] . obo:CHEBI_15727 obo:IAO_0000115 "A dipeptide that is the N-(beta-alanyl) derivative of L-histidine." ; chebi:charge "0" ; chebi:formula "C9H14N4O3" ; chebi:inchi "InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1" ; chebi:inchikey "CQOVPNPJLQNMDC-ZETCQYMHSA-N" ; chebi:mass "226.236" ; chebi:monoisotopicmass "226.10659" ; chebi:smiles "NCCC(=O)N[C@@H](CC1=CNC=N1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:13948", "CHEBI:23040", "CHEBI:3428" ; oboInOwl:hasDbXref "CAS:305-84-0", "Chemspider:388363", "DrugBank:DB11695", "HMDB:HMDB0000033", "KEGG:C00386", "KNApSAcK:C00052222", "PDBeChem:8V0", "PMID:10841274", "PMID:10951105", "PMID:10951108", "PMID:11470131", "PMID:11707898", "PMID:11911459", "PMID:11976203", "PMID:12139778", "PMID:15853927", "PMID:15878720", "PMID:15941308", "PMID:16162015", "PMID:16181134", "PMID:16287364", "PMID:16406688", "PMID:16804013", "PMID:17031479", "PMID:1735411", "PMID:17443912", "PMID:18019400", "PMID:18076890", "PMID:18773880", "PMID:19309105", "PMID:20017611", "PMID:20681748", "PMID:24398899", "PMID:2674258", "PMID:29463897", "PMID:31951767", "PMID:33586561", "PMID:33704575", "PMID:34067694", "PMID:8689392", "PMID:9029640", "PMID:9928418", "Reaxys:87671", "Wikipedia:Carnosine" ; oboInOwl:hasExactSynonym "Carnosine", "N(alpha)-(beta-alanyl)-L-histidine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid", "Karnozin", "Karnozzn", "L-carnosine", "N-(3-aminopropanoyl)-L-histidine", "N-2-M", "N-beta-alanyl-L-histidine", "Nalpha-(beta-alanyl)-L-histidine", "beta-alanyl-L-histidine", "ignotine" ; oboInOwl:id "CHEBI:15727" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carnosine" ; rdfs:subClassOf obo:CHEBI_46761, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_176497 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35610 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35623 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_63726 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66874 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57485 ] . obo:CHEBI_15734 obo:IAO_0000115 "A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." ; chebi:charge "0" ; chebi:formula "CH3OR" ; chebi:mass "31.034" ; chebi:monoisotopicmass "31.01839" ; chebi:smiles "*C(O)([H])[H]" ; oboInOwl:hasAlternativeId "CHEBI:13676", "CHEBI:14887", "CHEBI:26262", "CHEBI:57489", "CHEBI:8406" ; oboInOwl:hasDbXref "KEGG:C00226" ; oboInOwl:hasExactSynonym "Primary alcohol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-Alcohol", "a primary alcohol", "primary alcohols" ; oboInOwl:id "CHEBI:15734" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary alcohol" ; rdfs:subClassOf obo:CHEBI_30879 . obo:CHEBI_15740 obo:IAO_0000115 "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." ; chebi:charge "-1" ; chebi:formula "CHO2" ; chebi:inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1" ; chebi:inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-M" ; chebi:mass "45.01744" ; chebi:monoisotopicmass "44.99820" ; chebi:smiles "[H]C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14276", "CHEBI:24081" ; oboInOwl:hasDbXref "Beilstein:1901205", "CAS:71-47-6", "Gmelin:1006", "HMDB:HMDB0000142", "KEGG:C00058", "MetaCyc:FORMATE", "PMID:17190852", "PMID:3946945", "Reaxys:1901205", "UM-BBD_compID:c0106", "Wikipedia:Formate" ; oboInOwl:hasExactSynonym "formate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HCO2 anion", "aminate", "formiate", "formic acid, ion(1-)", "formylate", "hydrogen carboxylate", "methanoate" ; oboInOwl:id "CHEBI:15740" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "formate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30751 ] . obo:CHEBI_15756 obo:IAO_0000115 "A straight-chain, sixteen-carbon, saturated long-chain fatty acid." ; chebi:charge "0" ; chebi:formula "C16H32O2" ; chebi:inchi "InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)" ; chebi:inchikey "IPCSVZSSVZVIGE-UHFFFAOYSA-N" ; chebi:mass "256.42410" ; chebi:monoisotopicmass "256.24023" ; chebi:smiles "CCCCCCCCCCCCCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14730", "CHEBI:233028", "CHEBI:24540", "CHEBI:24541", "CHEBI:24542", "CHEBI:24550", "CHEBI:29889", "CHEBI:35978", "CHEBI:44952" ; oboInOwl:hasDbXref "Beilstein:607489", "CAS:57-10-3", "DrugBank:DB03796", "Gmelin:190200", "HMDB:HMDB0000220", "KEGG:C00249", "KEGG:D05341", "KNApSAcK:C00001233", "KNApSAcK:C00030479", "LIPID_MAPS_instance:LMFA01010001", "MetaCyc:PALMITATE", "PDBeChem:PLM", "PMID:12492626", "PMID:15357969", "PMID:1589452", "PMID:16509590", "PMID:16884313", "PMID:17439666", "PMID:17502136", "PMID:20001317", "PMID:22735334", "PMID:25584012", "PMID:28600633", "PPDB:1336", "Reaxys:607489", "Wikipedia:Palmitic_acid" ; oboInOwl:hasExactSynonym "hexadecanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-Pentadecanecarboxylic acid", "1-hexyldecanoic acid", "16:00", "C16", "C16 fatty acid", "C16:0", "CH3-[CH2]14-COOH", "FA 16:0", "Hexadecanoate", "Hexadecylic acid", "Hexaectylic acid", "PALMITIC ACID", "Palmitate", "Palmitic acid", "Palmitinic acid", "Palmitinsaeure", "Pentadecanecarboxylic acid", "cetylic acid", "hexadecoic acid", "n-hexadecanoic acid", "n-hexadecoic acid", "palmitic acid" ; oboInOwl:id "CHEBI:15756" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexadecanoic acid" ; rdfs:subClassOf obo:CHEBI_15904, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77119 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_7896 ] . obo:CHEBI_157668 obo:IAO_0000115 "Any fatty acid anion containing a ring composed of carbon atoms. Major microspecies at pH 7.3" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbocyclic fatty acid" ; oboInOwl:id "CHEBI:157668" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "carbocyclic fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35744 ] . obo:CHEBI_157750 obo:IAO_0000115 "A carbohydrate acid derivative anion that is a polyanionic form of heparan sulfate arising from global deprotonation of the carboxy and N-sulfo groups; major species at pH 7.3." ; chebi:charge "-4" ; chebi:formula "(C12H15NO20S3)n" ; chebi:mass "0.0" ; chebi:monoisotopicmass "0.0" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heparan sulfate group" ; oboInOwl:id "CHEBI:157750" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "heparan sulfate polyanion" ; rdfs:subClassOf obo:CHEBI_60164, obo:CHEBI_61660, obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28815 ] . obo:CHEBI_15778 obo:IAO_0000115 "Any N-acyl-amino acid in which the amino acid moiety has D configuration." ; chebi:charge "0" ; chebi:formula "C3H3NO3R2" ; chebi:mass "101.06080" ; chebi:monoisotopicmass "101.01129" ; chebi:smiles "OC(=O)[C@@H]([*])NC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:12474", "CHEBI:21631", "CHEBI:7224" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:15778" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-D-amino acid" ; rdfs:subClassOf obo:CHEBI_51569, obo:CHEBI_83812, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59876 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_21644 ] . obo:CHEBI_15792 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by the deprotonation of the carboxy groups of malonic acid." ; chebi:charge "-2" ; chebi:formula "C3H2O4" ; chebi:inchi "InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)/p-2" ; chebi:inchikey "OFOBLEOULBTSOW-UHFFFAOYSA-L" ; chebi:mass "102.04558" ; chebi:monoisotopicmass "101.99641" ; chebi:smiles "[O-]C(=O)CC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14563", "CHEBI:25130", "CHEBI:44151" ; oboInOwl:hasDbXref "Beilstein:3904386", "CAS:156-80-9", "DrugBank:DB02201", "Gmelin:141932", "KEGG:C00383", "PDBeChem:MLI", "Reaxys:3904386" ; oboInOwl:hasExactSynonym "propanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)OOC-CH2-COO(-)", "MALONATE ION", "malo", "malonate", "malonic acid, ion(2-)", "propanedioic acid, ion(2-)" ; oboInOwl:id "CHEBI:15792" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "malonate(2-)" ; rdfs:subClassOf obo:CHEBI_133291, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30795 ] . obo:CHEBI_15801 obo:IAO_0000115 "A 2-hydroxyglutarate(2-) that has (2R)-configuration." ; chebi:charge "-2" ; chebi:formula "C5H6O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/p-2/t3-/m1/s1" ; chebi:inchikey "HWXBTNAVRSUOJR-GSVOUGTGSA-L" ; chebi:mass "146.09814" ; chebi:monoisotopicmass "146.02262" ; chebi:smiles "O[C@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:10974", "CHEBI:18650" ; oboInOwl:hasDbXref "KEGG:C01087", "MetaCyc:R-2-HYDROXYGLUTARATE" ; oboInOwl:hasExactSynonym "(2R)-2-hydroxypentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-2-hydroxyglutarate" ; oboInOwl:id "CHEBI:15801" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-2-hydroxyglutarate(2-)" ; rdfs:subClassOf obo:CHEBI_11596, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16782 ] . obo:CHEBI_15841 obo:IAO_0000115 "A peptide containing ten or more amino acid residues." ; chebi:formula "C4H6N2O3R2(C2H2NOR)n" ; oboInOwl:hasAlternativeId "CHEBI:14860", "CHEBI:8314" ; oboInOwl:hasDbXref "KEGG:C00403" ; oboInOwl:hasExactSynonym "Polypeptide", "polypeptides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Polypeptid", "polipeptido" ; oboInOwl:id "CHEBI:15841" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polypeptide" ; rdfs:subClassOf obo:CHEBI_16670, obo:CHEBI_33839 . obo:CHEBI_15889 obo:IAO_0000115 "Any 3-hydroxy steroid whose skeleton is closely related to cholestan-3-ol (additional carbon atoms may be present in the side chain)." ; chebi:charge "0" ; chebi:formula "C19H31OR" ; chebi:mass "275.450" ; chebi:monoisotopicmass "275.23749" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)O)C" ; oboInOwl:hasAlternativeId "CHEBI:13688", "CHEBI:15114", "CHEBI:26771", "CHEBI:9266" ; oboInOwl:hasDbXref "KEGG:C00370", "LIPID_MAPS_class:LMST01", "MetaCyc:Sterols", "Wikipedia:Sterol" ; oboInOwl:hasExactSynonym "Sterol", "sterols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxysteroids", "a sterol" ; oboInOwl:id "CHEBI:15889" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sterol" ; rdfs:subClassOf obo:CHEBI_36834 . obo:CHEBI_15891 obo:IAO_0000115 "An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension." ; chebi:charge "0" ; chebi:formula "C2H7NO3S" ; chebi:inchi "InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)" ; chebi:inchikey "XOAAWQZATWQOTB-UHFFFAOYSA-N" ; chebi:mass "125.148" ; chebi:monoisotopicmass "125.01466" ; chebi:smiles "C(CS(O)(=O)=O)N" ; oboInOwl:hasAlternativeId "CHEBI:15195", "CHEBI:26852", "CHEBI:45877", "CHEBI:9406" ; oboInOwl:hasDbXref "Beilstein:1751215", "CAS:107-35-7", "DrugBank:DB01956", "Drug_Central:4486", "Gmelin:82121", "HMDB:HMDB0000251", "KEGG:C00245", "KEGG:D00047", "KNApSAcK:C00048188", "MetaCyc:TAURINE", "PDBeChem:TAU", "PMID:10098958", "PMID:10325611", "PMID:10349454", "PMID:10827156", "PMID:11162030", "PMID:11842876", "PMID:11918831", "PMID:11931837", "PMID:12297216", "PMID:12499349", "PMID:12834252", "PMID:14992292", "PMID:15503229", "PMID:15780050", "PMID:15911239", "PMID:16169526", "PMID:16444816", "PMID:16923232", "PMID:17053427", "PMID:17081118", "PMID:17875433", "PMID:17997039", "PMID:18060526", "PMID:18171928", "PMID:19074966", "PMID:19212411", "PMID:19309105", "PMID:19940987", "PMID:2122710", "PMID:21761941", "PMID:22770225", "PMID:2370482", "PMID:24027187", "PMID:2494044", "PMID:27291853", "PMID:27334436", "PMID:27345710", "PMID:27380030", "PMID:27412799", "PMID:27471162", "PMID:27535560", "PMID:3106924", "PMID:3393260", "PMID:6198473", "PMID:7588651", "PMID:8692051", "PMID:8818047", "PMID:9635063", "Reaxys:1751215", "Wikipedia:Taurine" ; oboInOwl:hasExactSynonym "2-aminoethanesulfonic acid", "Taurine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Aminoethanesulfonic acid", "2-aminoethyl sulfonate", "Aminoethylsulfonic acid", "beta-aminoethylsulfonic acid" ; oboInOwl:id "CHEBI:15891" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "taurine" ; rdfs:subClassOf obo:CHEBI_37793, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33284 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48578 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64589 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32970 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_507393 ] . obo:CHEBI_15903 obo:IAO_0000115 "D-Glucopyranose with beta configuration at the anomeric centre." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1" ; chebi:inchikey "WQZGKKKJIJFFOK-VFUOTHLCSA-N" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; chebi:smiles "OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O" ; oboInOwl:hasAlternativeId "CHEBI:10397", "CHEBI:12373", "CHEBI:22795", "CHEBI:41140" ; oboInOwl:hasDbXref "Beilstein:1281607", "CAS:492-61-5", "DrugBank:DB02379", "Drug_Central:845", "GlyGen:G71142DF", "GlyTouCan:G71142DF", "Gmelin:648637", "KEGG:C00221", "PDBeChem:BGC", "PMID:19443021", "PMID:25568069", "PMID:31537530", "PMID:32568414", "Reaxys:1281607" ; oboInOwl:hasExactSynonym "BETA-D-GLUCOSE", "beta-D-Glucose", "beta-D-glucopyranose", "beta-D-glucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "WURCS=2.0/1,1,0/[a2122h-1b_1-5]/1/" ; oboInOwl:id "CHEBI:15903" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-D-glucose" ; rdfs:subClassOf obo:CHEBI_4167, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_37631 ] . obo:CHEBI_15904 obo:IAO_0000115 "A fatty acid with a chain length ranging from C13 to C22." ; chebi:charge "0" ; chebi:formula "CHO2R" ; chebi:mass "45.017" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "OC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13655", "CHEBI:14529", "CHEBI:25075", "CHEBI:6528" ; oboInOwl:hasDbXref "KEGG:C00638" ; oboInOwl:hasExactSynonym "Long-chain fatty acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Higher fatty acid", "LCFA", "LCFAs", "long-chain fatty acids" ; oboInOwl:id "CHEBI:15904" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "long-chain fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57560 ] . obo:CHEBI_15963 obo:IAO_0000115 "A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from ribose by reduction of the carbonyl group. It occurs naturally in the plant Adonis vernalis." ; chebi:charge "0" ; chebi:formula "C5H12O5" ; chebi:inchi "InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5-" ; chebi:inchikey "HEBKCHPVOIAQTA-ZXFHETKHSA-N" ; chebi:mass "152.14578" ; chebi:monoisotopicmass "152.06847" ; chebi:smiles "OC[C@H](O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:15043", "CHEBI:21074", "CHEBI:26552", "CHEBI:27854", "CHEBI:4230", "CHEBI:48505", "CHEBI:57591", "CHEBI:8841" ; oboInOwl:hasDbXref "Beilstein:1720524", "CAS:488-81-3", "Gmelin:82894", "HMDB:HMDB0000508", "KEGG:C00474", "KNApSAcK:C00001171", "MetaCyc:RIBITOL", "PMID:15234337", "PMID:16664320", "PMID:16901854", "PMID:17336832", "PMID:17979222", "PMID:23564164", "PMID:24643482", "PMID:25108762", "Reaxys:1720524", "Wikipedia:Ribitol" ; oboInOwl:hasExactSynonym "(2R,3s,4S)-pentane-1,2,3,4,5-pentol", "Ribitol", "meso-ribitol", "ribitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R,3s,4S)-pentane-1,2,3,4,5-pentol", "Adonitol", "D-Adonitol", "D-Ribitol", "L-ribitol" ; oboInOwl:id "CHEBI:15963" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ribitol" ; rdfs:subClassOf obo:CHEBI_25899, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ] . obo:CHEBI_15966 obo:IAO_0000115 "An optically active form of glutamic acid having D-configuration." ; chebi:charge "0" ; chebi:formula "C5H9NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-N" ; chebi:mass "147.12930" ; chebi:monoisotopicmass "147.05316" ; chebi:smiles "N[C@H](CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:21023", "CHEBI:4183" ; oboInOwl:hasDbXref "Beilstein:1723800", "CAS:6893-26-1", "DrugBank:DB02517", "Gmelin:201189", "HMDB:HMDB0003339", "KEGG:C00217", "KNApSAcK:C00019577", "MetaCyc:D-GLT", "PDBeChem:DGL", "Reaxys:1723800" ; oboInOwl:hasExactSynonym "(2R)-2-aminopentanedioic acid", "D-Glutamic acid", "D-glutamic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-2-aminopentanedioic acid", "D-2-Aminoglutaric acid", "D-Glutaminic acid", "D-Glutaminsaeure", "DGL", "glutamic acid D-form" ; oboInOwl:id "CHEBI:15966" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glutamic acid" ; rdfs:subClassOf obo:CHEBI_16733, obo:CHEBI_18237, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29986 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16015 ] . obo:CHEBI_15999 obo:IAO_0000115 "A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group." ; chebi:charge "0" ; chebi:formula "C9H8O4" ; chebi:inchi "InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)" ; chebi:inchikey "KKADPXVIOXHVKN-UHFFFAOYSA-N" ; chebi:mass "180.159" ; chebi:monoisotopicmass "180.04226" ; chebi:smiles "OC(=O)C(=O)CC1=CC=C(O)C=C1" ; oboInOwl:hasAlternativeId "CHEBI:1431", "CHEBI:20426", "CHEBI:42422" ; oboInOwl:hasDbXref "Beilstein:2691632", "CAS:156-39-8", "DrugBank:DB07718", "HMDB:HMDB0000707", "KEGG:C01179", "KNApSAcK:C00007512", "MetaCyc:P-HYDROXY-PHENYLPYRUVATE", "PDBeChem:ENO", "PMID:11073718", "PMID:9106023", "Reaxys:2691632", "Wikipedia:4-Hydroxyphenylpyruvic_acid" ; oboInOwl:hasExactSynonym "3-(4-hydroxyphenyl)-2-oxopropanoic acid", "4-hydroxyphenylpyruvic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(4-hydroxyphenyl)pyruvic acid", "(p-hydroxyphenyl)pyruvic acid", "3-(4-HYDROXY-PHENYL)PYRUVIC ACID", "3-(4-hydroxyphenyl)pyruvic acid", "3-(p-hydroxyphenyl)-2-oxopropanoic acid", "4-hydroxy alpha-oxobenzenepropanoic acid", "p-Hydroxyphenylpyruvic acid" ; oboInOwl:id "CHEBI:15999" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyphenylpyruvic acid" ; rdfs:subClassOf obo:CHEBI_33853, obo:CHEBI_35910, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_32816 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_36242 ] . obo:CHEBI_16004 obo:IAO_0000115 "An optically active form of lactate having (R)-configuration." ; chebi:charge "-1" ; chebi:formula "C3H5O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1" ; chebi:inchikey "JVTAAEKCZFNVCJ-UWTATZPHSA-M" ; chebi:mass "89.07000" ; chebi:monoisotopicmass "89.02442" ; chebi:smiles "C[C@@H](O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11001", "CHEBI:18684" ; oboInOwl:hasDbXref "Beilstein:4655978", "Gmelin:362716", "KEGG:C00256", "MetaCyc:D-LACTATE", "Reaxys:4655978" ; oboInOwl:hasExactSynonym "(2R)-2-hydroxypropanoate", "(R)-lactate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-2-hydroxypropanoate", "D-2-hydroxypropionate", "D-lactate" ; oboInOwl:id "CHEBI:16004" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-lactate" ; rdfs:subClassOf obo:CHEBI_24996, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_42111 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16651 ] . obo:CHEBI_16010 obo:IAO_0000115 "An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle." ; chebi:charge "0" ; chebi:formula "C5H7NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)" ; chebi:inchikey "ODHCTXKNWHHXJC-UHFFFAOYSA-N" ; chebi:mass "129.11400" ; chebi:monoisotopicmass "129.04259" ; chebi:smiles "OC(=O)C1CCC(=O)N1" ; oboInOwl:hasAlternativeId "CHEBI:12157", "CHEBI:20624", "CHEBI:2116", "CHEBI:44943" ; oboInOwl:hasDbXref "Beilstein:82131", "CAS:149-87-1", "PMID:17439666", "PMID:22770225", "PMID:23217740", "Reaxys:82131", "Wikipedia:Pyroglutamic_acid" ; oboInOwl:hasExactSynonym "5-OXOPROLINE", "5-Oxoproline", "5-oxoproline", "5-oxopyrrolidine-2-carboxylic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-pyrrolidone-5-carboxylic acid", "5-Pyrrolidone-2-carboxylic acid", "5-oxo-DL-proline", "Glp", "Pyroglutamate", "Pyroglutamic acid" ; oboInOwl:id "CHEBI:16010" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxoproline" ; rdfs:subClassOf obo:CHEBI_25801, obo:CHEBI_46701, obo:CHEBI_74223, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57606 ] . obo:CHEBI_16015 obo:IAO_0000115 "An optically active form of glutamic acid having L-configuration." ; chebi:charge "0" ; chebi:formula "C5H9NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-N" ; chebi:mass "147.12930" ; chebi:monoisotopicmass "147.05316" ; chebi:smiles "N[C@@H](CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:21304", "CHEBI:42825", "CHEBI:6224" ; oboInOwl:hasDbXref "BPDB:2297", "Beilstein:1723801", "CAS:56-86-0", "DrugBank:DB00142", "Drug_Central:1310", "Gmelin:3502", "HMDB:HMDB0000148", "KEGG:C00025", "KEGG:D00007", "KNApSAcK:C00001358", "LINCS:LSM-36375", "MetaCyc:GLT", "PDBeChem:GLU_LFOH", "PMID:15739367", "PMID:15930465", "PMID:16719819", "PMID:16892196", "PMID:19581495", "PMID:22219301", "PMID:22735334", "Reaxys:1723801", "Wikipedia:L-Glutamic_Acid" ; oboInOwl:hasExactSynonym "(2S)-2-aminopentanedioic acid", "L-Glutamic acid", "L-glutamic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-aminopentanedioic acid", "(S)-glutamic acid", "E", "GLUTAMIC ACID", "Glu", "Glutamate", "L-Glu", "L-Glutaminic acid", "L-Glutaminsaeure", "acide glutamique", "acido glutamico", "acidum glutamicum", "glutamic acid" ; oboInOwl:id "CHEBI:16015" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glutamic acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_18237, obo:CHEBI_24318, obo:CHEBI_83813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_173085 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29985 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_15966 ] . obo:CHEBI_16024 obo:IAO_0000115 "A mannose with D-configuration." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:12999", "CHEBI:21057" ; oboInOwl:hasExactSynonym "D-manno-hexose", "D-mannose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:16024" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-mannose" ; rdfs:subClassOf obo:CHEBI_17608, obo:CHEBI_37684, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ] . obo:CHEBI_16042 obo:IAO_0000115 "A monoatomic monoanion resulting from the addition of an electron to any halogen atom." ; chebi:charge "-1" ; chebi:formula "X" ; chebi:mass "0.0" ; chebi:monoisotopicmass "0.0" ; chebi:smiles "[*-]" ; oboInOwl:hasAlternativeId "CHEBI:14384", "CHEBI:5605" ; oboInOwl:hasDbXref "KEGG:C00462" ; oboInOwl:hasExactSynonym "halide ions" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HX", "Halide", "a halide anion", "halide anions", "halide(1-)", "halides", "halogen anion" ; oboInOwl:id "CHEBI:16042" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "halide anion" ; rdfs:subClassOf obo:CHEBI_33429, obo:CHEBI_79389 . obo:CHEBI_16070 obo:IAO_0000115 "An anhydro sugar of D-glucitol." ; chebi:charge "0" ; chebi:formula "C6H12O5" ; chebi:inchi "InChI=1S/C6H12O5/c7-1-4-6(10)5(9)3(8)2-11-4/h3-10H,1-2H2/t3-,4+,5+,6+/m0/s1" ; chebi:inchikey "MPCAJMNYNOGXPB-SLPGGIOYSA-N" ; chebi:mass "164.15648" ; chebi:monoisotopicmass "164.06847" ; chebi:smiles "OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O" ; oboInOwl:hasAlternativeId "CHEBI:11176", "CHEBI:18943", "CHEBI:40816", "CHEBI:550" ; oboInOwl:hasDbXref "CAS:154-58-5", "HMDB:HMDB0002712", "KEGG:C07326", "PDBeChem:ASO", "PMID:15277408", "PMID:18492944", "PMID:19796288", "Reaxys:80736", "Wikipedia:1,5-Anhydroglucitol" ; oboInOwl:hasExactSynonym "(2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol", "1,5-Anhydro-D-glucitol", "1,5-anhydro-D-glucitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,5-ANHYDROSORBITOL", "1,5-Anhydro-D-sorbitol", "1,5-Anhydroglucitol", "1,5-anhydro-D-sorbitol", "1,5-anhydroglucitol" ; oboInOwl:id "CHEBI:16070" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1,5-anhydro-D-glucitol" ; rdfs:subClassOf obo:CHEBI_22558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17924 ] . obo:CHEBI_16080 obo:IAO_0000115 "A gamma-amino acid comprising 4-aminobutyric acid having a 2-hydroxy substituent." ; chebi:charge "0" ; chebi:formula "C4H9NO3" ; chebi:inchi "InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)" ; chebi:inchikey "YQGDEPYYFWUPGO-UHFFFAOYSA-N" ; chebi:mass "119.11920" ; chebi:monoisotopicmass "119.05824" ; chebi:smiles "NCC(O)CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:1780", "CHEBI:20311" ; oboInOwl:hasDbXref "Beilstein:1721708", "Beilstein:1752568", "CAS:352-21-6", "Drug_Central:1263", "KEGG:C03678", "KEGG:D00174" ; oboInOwl:hasExactSynonym "4-amino-3-hydroxybutanoic acid", "gamma-Amino-beta-hydroxybutyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy-GABA", "4-Amino-3-hydroxybutanoic acid", "4-amino-3-hydroxybutyric acid", "GABOB" ; oboInOwl:id "CHEBI:16080" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-amino-beta-hydroxybutyric acid" ; rdfs:subClassOf obo:CHEBI_33707, obo:CHEBI_35969, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_11955 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57630 ] . obo:CHEBI_16094 obo:IAO_0000115 "A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid." ; chebi:charge "-2" ; chebi:formula "O3S2" ; chebi:inchi "InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" ; chebi:inchikey "DHCDFWKWKRSZHF-UHFFFAOYSA-L" ; chebi:mass "112.13020" ; chebi:monoisotopicmass "111.92998" ; chebi:smiles "[O-]S([S-])(=O)=O" ; oboInOwl:hasAlternativeId "CHEBI:15242", "CHEBI:45922", "CHEBI:9569" ; oboInOwl:hasDbXref "CAS:14383-50-7", "Gmelin:2031", "PDBeChem:THJ" ; oboInOwl:hasExactSynonym "sulfurothioate", "thiosulfate", "trioxidosulfidosulfate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hyposulfite", "S2O3", "S2O3(2-)", "TETRATHIONATE", "Thiosulfate", "[SO3S](2-)", "thiosulfate ion(2-)", "thiosulphate", "trioxido-1kappa(3)O-disulfate(S--S)(2-)" ; oboInOwl:id "CHEBI:16094" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thiosulfate(2-)" ; rdfs:subClassOf obo:CHEBI_33482, obo:CHEBI_48154, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33541 ] . obo:CHEBI_16113 obo:IAO_0000115 "A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group." ; chebi:charge "0" ; chebi:formula "C27H46O" ; chebi:inchi "InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1" ; chebi:inchikey "HVYWMOMLDIMFJA-DPAQBDIFSA-N" ; chebi:mass "386.655" ; chebi:monoisotopicmass "386.35487" ; chebi:smiles "C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3(CC=C2C[C@H](C1)O)[H])(CC[C@@]4([C@H](C)CCCC(C)C)[H])[H])C)[H])C" ; oboInOwl:hasAlternativeId "CHEBI:13982", "CHEBI:23204", "CHEBI:3659", "CHEBI:41564" ; oboInOwl:hasDbXref "Beilstein:2060565", "CAS:57-88-5", "DrugBank:DB04540", "Gmelin:550297", "HMDB:HMDB0000067", "KEGG:C00187", "KEGG:D00040", "KNApSAcK:C00003648", "LIPID_MAPS_instance:LMST01010001", "MetaCyc:CHOLESTEROL", "PDBeChem:CLR", "PMID:10901445", "PMID:11412894", "PMID:16341241", "PMID:24287311", "PMID:25308664", "PMID:25451949", "PMID:25522988", "PMID:25658343", "PMID:25977713", "PMID:4696527", "PMID:8838010", "Reaxys:2060565", "Wikipedia:Cholesterol" ; oboInOwl:hasExactSynonym "CHOLESTEROL", "Cholesterol", "cholest-5-en-3beta-ol", "cholesterol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(3beta,14beta,17alpha)-cholest-5-en-3-ol", "Cholest-5-en-3beta-ol", "Cholesterin" ; oboInOwl:id "CHEBI:16113" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholesterol" ; rdfs:subClassOf obo:CHEBI_131619, obo:CHEBI_1722, obo:CHEBI_35348, obo:CHEBI_50401, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83038 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ] . obo:CHEBI_16134 obo:IAO_0000115 "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." ; chebi:charge "0" ; chebi:formula "H3N" ; chebi:inchi "InChI=1S/H3N/h1H3" ; chebi:inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-N" ; chebi:mass "17.03056" ; chebi:monoisotopicmass "17.02655" ; chebi:smiles "[H]N([H])[H]" ; oboInOwl:hasAlternativeId "CHEBI:13405", "CHEBI:13406", "CHEBI:13407", "CHEBI:13771", "CHEBI:22533", "CHEBI:44269", "CHEBI:44284", "CHEBI:44404", "CHEBI:7434" ; oboInOwl:hasDbXref "Beilstein:3587154", "CAS:7664-41-7", "Drug_Central:4625", "Gmelin:79", "HMDB:HMDB0000051", "KEGG:C00014", "KEGG:D02916", "KNApSAcK:C00007267", "MetaCyc:AMMONIA", "MolBase:930", "PDBeChem:NH3", "PMID:110589", "PMID:11139349", "PMID:11540049", "PMID:11746427", "PMID:11783653", "PMID:13753780", "PMID:14663195", "PMID:15092448", "PMID:15094021", "PMID:15554424", "PMID:15969015", "PMID:16008360", "PMID:16050680", "PMID:16348008", "PMID:16349403", "PMID:16614889", "PMID:16664306", "PMID:16842901", "PMID:17025297", "PMID:17439666", "PMID:17569513", "PMID:17737668", "PMID:18670398", "PMID:22002069", "PMID:22081570", "PMID:22088435", "PMID:22100291", "PMID:22130175", "PMID:22150211", "PMID:22240068", "PMID:22290316", "PMID:22342082", "PMID:22385337", "PMID:22443779", "PMID:22560242", "Reaxys:3587154", "Wikipedia:Ammonia" ; oboInOwl:hasExactSynonym "AMMONIA", "Ammonia", "ammonia", "azane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Ammoniak", "NH3", "R-717", "[NH3]", "ammoniac", "amoniaco", "spirit of hartshorn" ; oboInOwl:id "CHEBI:16134" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ammonia" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_35107, obo:CHEBI_37176, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50910 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59740 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77941 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78433 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29337 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28938 ] . obo:CHEBI_16135 obo:IAO_0000115 "A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2." ; chebi:charge "0" ; chebi:formula "C4H8O2" ; chebi:inchi "InChI=1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)" ; chebi:inchikey "KQNPFQTWMSNSAP-UHFFFAOYSA-N" ; chebi:mass "88.10512" ; chebi:monoisotopicmass "88.05243" ; chebi:smiles "CC(C)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:1212", "CHEBI:19710", "CHEBI:25337", "CHEBI:40653", "CHEBI:43397" ; oboInOwl:hasDbXref "BPDB:3128", "Beilstein:635770", "CAS:79-31-2", "DrugBank:DB02531", "Gmelin:49630", "HMDB:HMDB0001873", "KEGG:C02632", "KNApSAcK:C00029462", "LIPID_MAPS_instance:LMFA01020071", "MetaCyc:ISOBUTYRATE", "PDBeChem:ALQ", "PMID:10757489", "PMID:17580301", "PMID:17877388", "PPDB:3128", "Reaxys:635770", "UM-BBD_compID:c0383", "Wikipedia:Isobutyric_acid" ; oboInOwl:hasExactSynonym "2-methylpropanoic acid", "ISOBUTYRIC ACID", "Isobutyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,2-dimethylacetic acid", "2-METHYL-PROPIONIC ACID", "2-Methylpropanoate", "2-Methylpropanoic acid", "2-Methylpropionsaeure", "Dimethylacetic acid", "Isobutanoate", "Isobuttersaeure", "Isobutyrate", "alpha-isobutyric acid", "alpha-methylpropanoic acid", "alpha-methylpropionic acid", "iso-C3H7COOH", "iso-butyric acid", "isobutanoic acid", "isopropylformic acid" ; oboInOwl:id "CHEBI:16135" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isobutyric acid" ; rdfs:subClassOf obo:CHEBI_140601, obo:CHEBI_39417, obo:CHEBI_62499, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27311 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_48944 ] . obo:CHEBI_16137 obo:IAO_0000115 "A mucopolysaccharide composed of repeating beta-D-glucopyranuronosyl-(1->3)-beta-D-N-acetylgalactosaminyl units." ; chebi:formula "(C14H21NO11)nH2O" ; oboInOwl:hasAlternativeId "CHEBI:13989", "CHEBI:13992", "CHEBI:23221", "CHEBI:3673" ; oboInOwl:hasDbXref "KEGG:C00401", "KEGG:G11334" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chondroitin", "Chondroitin-D-glucuronate" ; oboInOwl:id "CHEBI:16137" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chondroitin D-glucuronate" ; rdfs:subClassOf obo:CHEBI_37395, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57652 ] . obo:CHEBI_16180 obo:IAO_0000115 "An N-acyl-amino acid in which amino acid specified is glycine." ; chebi:charge "0" ; chebi:formula "C3H4NO3R" ; chebi:mass "102.06880" ; chebi:monoisotopicmass "102.01912" ; chebi:smiles "OC(=O)CNC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:12484", "CHEBI:21660", "CHEBI:7238" ; oboInOwl:hasDbXref "KEGG:C02055", "MetaCyc:CPD-426" ; oboInOwl:hasExactSynonym "N-Acylglycine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:16180" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acylglycine" ; rdfs:subClassOf obo:CHEBI_140325, obo:CHEBI_24373, obo:CHEBI_51569, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57670 ] . obo:CHEBI_16189 obo:IAO_0000115 "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." ; chebi:charge "-2" ; chebi:formula "O4S" ; chebi:inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" ; chebi:inchikey "QAOWNCQODCNURD-UHFFFAOYSA-L" ; chebi:mass "96.06360" ; chebi:monoisotopicmass "95.95283" ; chebi:smiles "[O-]S([O-])(=O)=O" ; oboInOwl:hasAlternativeId "CHEBI:15135", "CHEBI:45687", "CHEBI:9335" ; oboInOwl:hasDbXref "Beilstein:3648446", "CAS:14808-79-8", "Gmelin:2120", "HMDB:HMDB0001448", "KEGG:C00059", "KEGG:D05963", "MetaCyc:SULFATE", "PDBeChem:SO4", "PMID:11200094", "PMID:11452993", "PMID:11581495", "PMID:11798107", "PMID:12166931", "PMID:12668033", "PMID:14597181", "PMID:15093386", "PMID:15984785", "PMID:16186560", "PMID:16345535", "PMID:16347366", "PMID:16348007", "PMID:16483812", "PMID:16534979", "PMID:16656509", "PMID:16742508", "PMID:16742518", "PMID:17120760", "PMID:17420092", "PMID:17439666", "PMID:17709180", "PMID:18398178", "PMID:18815700", "PMID:18846414", "PMID:19047345", "PMID:19244483", "PMID:19544990", "PMID:19628332", "PMID:19812358", "PMID:30398859", "Reaxys:3648446", "Wikipedia:Sulfate" ; oboInOwl:hasExactSynonym "Sulfate", "sulfate", "tetraoxidosulfate(2-)", "tetraoxosulfate(2-)", "tetraoxosulfate(VI)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "SO4(2-)", "SULFATE ION", "Sulfate anion(2-)", "Sulfate dianion", "Sulfate(2-)", "Sulfuric acid ion(2-)", "[SO4](2-)", "sulphate", "sulphate ion" ; oboInOwl:id "CHEBI:16189" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfate" ; rdfs:subClassOf obo:CHEBI_24834, obo:CHEBI_33482, obo:CHEBI_48154, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_45696 ] . obo:CHEBI_16199 obo:IAO_0000115 "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)." ; chebi:charge "0" ; chebi:formula "CH4N2O" ; chebi:inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" ; chebi:inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" ; chebi:mass "60.05534" ; chebi:monoisotopicmass "60.03236" ; chebi:smiles "NC(N)=O" ; oboInOwl:hasAlternativeId "CHEBI:15292", "CHEBI:27218", "CHEBI:46379", "CHEBI:9888" ; oboInOwl:hasDbXref "Beilstein:635724", "CAS:57-13-6", "DrugBank:DB03904", "Drug_Central:4264", "ECMDB:ECMDB04172", "Gmelin:1378", "HMDB:HMDB0000294", "KEGG:C00086", "KEGG:D00023", "KNApSAcK:C00007314", "MetaCyc:UREA", "PDBeChem:URE", "PMID:18037357", "PMID:22770225", "PPDB:1728", "Reaxys:635724", "UM-BBD_compID:c0165", "Wikipedia:Urea", "YMDB:YMDB00003" ; oboInOwl:hasExactSynonym "UREA", "Urea", "urea" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1728", "Carbamide", "E927b", "H2NC(O)NH2", "Harnstoff", "Karbamid", "carbamide", "carbonyldiamide", "ur", "uree" ; oboInOwl:id "CHEBI:16199" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urea" ; rdfs:subClassOf obo:CHEBI_29347, obo:CHEBI_64708, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33287 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64577 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_28976 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_48376 ] . obo:CHEBI_16235 obo:IAO_0000115 "A 2-aminopurine carrying a 6-oxo substituent." ; chebi:charge "0" ; chebi:formula "C5H5N5O" ; chebi:inchi "InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)" ; chebi:inchikey "UYTPUPDQBNUYGX-UHFFFAOYSA-N" ; chebi:mass "151.126" ; chebi:monoisotopicmass "151.04941" ; chebi:smiles "C12=C(N=C(NC1=O)N)NC=N2" ; oboInOwl:hasAlternativeId "CHEBI:14371", "CHEBI:14372", "CHEBI:24443", "CHEBI:42948", "CHEBI:5563" ; oboInOwl:hasDbXref "Beilstein:147911", "CAS:73-40-5", "DrugBank:DB02377", "Gmelin:431879", "HMDB:HMDB0000132", "KEGG:C00242", "KNApSAcK:C00001501", "MetaCyc:GUANINE", "PDBeChem:GUN", "PMID:22770225", "PMID:8070089", "Reaxys:147911", "Wikipedia:Guanine" ; oboInOwl:hasExactSynonym "2-amino-1,9-dihydro-6H-purin-6-one", "GUANINE", "Guanine", "guanine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-6-hydroxypurine", "2-amino-6-oxopurine", "G", "Gua" ; oboInOwl:id "CHEBI:16235" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "guanine" ; rdfs:subClassOf obo:CHEBI_20702, obo:CHEBI_25810, obo:CHEBI_26386, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35589 ] . obo:CHEBI_16247 obo:IAO_0000115 "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." ; oboInOwl:hasAlternativeId "CHEBI:14816", "CHEBI:26063", "CHEBI:8150" ; oboInOwl:hasDbXref "KEGG:C00865" ; oboInOwl:hasExactSynonym "Phospholipid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a phospholipid derivative", "phospholipids" ; oboInOwl:id "CHEBI:16247" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phospholipid" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_25703, obo:CHEBI_37734, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62643 ] . obo:CHEBI_16285 obo:IAO_0000115 "A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15." ; chebi:charge "0" ; chebi:formula "C20H40O2" ; chebi:inchi "InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)" ; chebi:inchikey "RLCKHJSFHOZMDR-UHFFFAOYSA-N" ; chebi:mass "312.53040" ; chebi:monoisotopicmass "312.30283" ; chebi:smiles "CC(C)CCCC(C)CCCC(C)CCCC(C)CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:26111", "CHEBI:8189" ; oboInOwl:hasDbXref "Beilstein:1789963", "CAS:14721-66-5", "KEGG:C01607", "LIPID_MAPS_instance:LMFA01020251", "PMID:12187408", "PMID:17956237", "PMID:9819701", "Reaxys:1789963" ; oboInOwl:hasExactSynonym "3,7,11,15-tetramethylhexadecanoic acid", "Phytanic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,7,11,15-Tetramethyl-hexadecansaeure", "3,7,11,15-tetramethyl hexadecanoic acid", "3,7,11,15-tetramethyl-hexadecanoic acid" ; oboInOwl:id "CHEBI:16285" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phytanic acid" ; rdfs:subClassOf obo:CHEBI_15904, obo:CHEBI_39417, obo:CHEBI_62499, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15756 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_48937 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_37257 ] . obo:CHEBI_16313 obo:IAO_0000115 "The D-enantiomer of proline." ; chebi:charge "0" ; chebi:formula "C5H9NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-N" ; chebi:mass "115.13050" ; chebi:monoisotopicmass "115.06333" ; chebi:smiles "OC(=O)[C@H]1CCCN1" ; oboInOwl:hasAlternativeId "CHEBI:13008", "CHEBI:21070", "CHEBI:42012", "CHEBI:42129", "CHEBI:42213", "CHEBI:4226", "CHEBI:45156" ; oboInOwl:hasDbXref "Beilstein:80811", "CAS:344-25-2", "DrugBank:DB02853", "Gmelin:833984", "HMDB:HMDB0003411", "KEGG:C00763", "MetaCyc:D-PROLINE", "PDBeChem:DPR", "PMID:19023642", "PMID:20023020", "PMID:20959625", "PMID:21374575", "PMID:21563681", "PMID:22475019", "PMID:22479580", "Reaxys:80811", "Wikipedia:D-proline" ; oboInOwl:hasExactSynonym "D-PROLINE", "D-Proline", "D-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-pyrrolidine-2-carboxylic acid", "(R)-2-Carboxypyrrolidine", "(R)-pyrrolidine-2-carboxylic acid", "D-Prolin", "DPR" ; oboInOwl:id "CHEBI:16313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-proline" ; rdfs:subClassOf obo:CHEBI_16733, obo:CHEBI_26271, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32867 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32868 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17203 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57726 ] . obo:CHEBI_16336 obo:IAO_0000115 "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." ; chebi:charge "0" ; chebi:formula "(C14H21NO12)n" ; oboInOwl:hasAlternativeId "CHEBI:14412", "CHEBI:24622", "CHEBI:24623", "CHEBI:5772" ; oboInOwl:hasDbXref "Beilstein:8538277", "CAS:9004-61-9", "HMDB:HMDB0010366", "KEGG:C00518", "KEGG:D08043", "KEGG:G10505", "PMID:11122186", "PMID:18056362", "PMID:18290544", "Reaxys:8187837", "Wikipedia:Hyaluronan" ; oboInOwl:hasExactSynonym "Hyaluronic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hyaluronsaeure", "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n", "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n", "acide hyaluronique", "acido hialuronico", "hyaluronan" ; oboInOwl:id "CHEBI:16336" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hyaluronic acid" ; rdfs:subClassOf obo:CHEBI_37395, obo:CHEBI_72813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132153 ] . obo:CHEBI_16385 obo:IAO_0000115 "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." ; chebi:charge "0" ; chebi:formula "SR2" ; chebi:mass "32.066" ; chebi:monoisotopicmass "31.97207" ; oboInOwl:hasAlternativeId "CHEBI:13694", "CHEBI:26960", "CHEBI:9340" ; oboInOwl:hasDbXref "KEGG:C00297" ; oboInOwl:hasExactSynonym "sulfides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "RSR", "Sulfide", "Thioether", "organic sulfides", "thioethers" ; oboInOwl:id "CHEBI:16385" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic sulfide" ; rdfs:subClassOf obo:CHEBI_26822, obo:CHEBI_33261 . obo:CHEBI_16449 obo:IAO_0000115 "An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)" ; chebi:inchikey "QNAYBMKLOCPYGJ-UHFFFAOYSA-N" ; chebi:mass "89.09322" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "CC(N)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:13748", "CHEBI:22277", "CHEBI:2539" ; oboInOwl:hasDbXref "Beilstein:635807", "CAS:302-72-7", "Drug_Central:4306", "Gmelin:2449", "KEGG:C01401", "PMID:17439666", "PMID:22264337", "Reaxys:635807", "Wikipedia:Alanine" ; oboInOwl:hasExactSynonym "2-aminopropanoic acid", "Alanine", "alanine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Aminopropanoic acid", "2-Aminopropionic acid", "A", "ALA", "Alanin", "alanina" ; oboInOwl:id "CHEBI:16449" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alanine" ; rdfs:subClassOf obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30768 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32439 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32440 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_66916 ] . obo:CHEBI_16498 obo:IAO_0000115 "Any neuraminic acid carrying an N-acyl substituent." ; chebi:charge "0" ; chebi:formula "C10H16NO9R" ; chebi:mass "294.23530" ; chebi:monoisotopicmass "294.08251" ; chebi:smiles "[H][C@]1(OC(O)(C[C@H](O)[C@H]1NC([*])=O)C(O)=O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:12485", "CHEBI:21664", "CHEBI:7240" ; oboInOwl:hasDbXref "KEGG:C00591" ; oboInOwl:hasExactSynonym "5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-Acylneuraminate", "N-acylneuraminic acids" ; oboInOwl:id "CHEBI:16498" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acylneuraminic acid" ; rdfs:subClassOf obo:CHEBI_26667, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_60073 ] . obo:CHEBI_16526 obo:IAO_0000115 "A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food." ; chebi:charge "0" ; chebi:formula "CO2" ; chebi:inchi "InChI=1S/CO2/c2-1-3" ; chebi:inchikey "CURLTUGMZLYLDI-UHFFFAOYSA-N" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "O=C=O" ; oboInOwl:hasAlternativeId "CHEBI:13282", "CHEBI:13283", "CHEBI:13284", "CHEBI:13285", "CHEBI:23011", "CHEBI:3283", "CHEBI:48829" ; oboInOwl:hasDbXref "Beilstein:1900390", "CAS:124-38-9", "Drug_Central:4256", "Gmelin:989", "HMDB:HMDB0001967", "KEGG:C00011", "KEGG:D00004", "MetaCyc:CARBON-DIOXIDE", "MolBase:752", "PDBeChem:CO2", "PMID:10826146", "PMID:11094503", "PMID:11584085", "PMID:11802652", "PMID:14639145", "PMID:15050588", "PMID:16591971", "PMID:16656478", "PMID:16659660", "PMID:17190796", "PMID:17448243", "PMID:17878298", "PMID:17884085", "PMID:19043767", "PMID:19259576", "PMID:19854893", "PMID:23384758", "PMID:23828359", "PMID:24258718", "PMID:8482095", "PMID:8818713", "PMID:8869828", "PMID:9611769", "PMID:9730350", "PPDB:119", "Reaxys:1900390", "UM-BBD_compID:c0131", "Wikipedia:Carbon_dioxide" ; oboInOwl:hasExactSynonym "CARBON DIOXIDE", "Carbon dioxide", "carbon dioxide", "dioxidocarbon", "methanedione" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CO2", "E 290", "E-290", "E290", "R-744", "[CO2]", "carbonic anhydride" ; oboInOwl:id "CHEBI:16526" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon dioxide" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_23014, obo:CHEBI_64708, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35620 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_38867 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_46787 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48706 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76413 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77974 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78433 ] . obo:CHEBI_16541 obo:IAO_0000115 "A naturally occurring polypeptide synthesized at the ribosome." ; oboInOwl:hasAlternativeId "CHEBI:8526" ; oboInOwl:hasDbXref "KEGG:C00017" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Protein", "a protein", "polypeptide chain", "protein polypeptide chains" ; oboInOwl:id "CHEBI:16541" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "protein polypeptide chain" ; rdfs:subClassOf obo:CHEBI_15841, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33700 ] . obo:CHEBI_16646 obo:IAO_0000115 "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." ; oboInOwl:hasAlternativeId "CHEBI:15131", "CHEBI:23008", "CHEBI:9318" ; oboInOwl:hasDbXref "Wikipedia:Carbohydrate" ; oboInOwl:hasExactSynonym "carbohydrate", "carbohydrates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Kohlenhydrat", "Kohlenhydrate", "a carbohydrate", "carbohidrato", "carbohidratos", "glucide", "glucides", "glucido", "glucidos", "hydrates de carbone", "saccharide", "saccharides", "saccharidum" ; oboInOwl:id "CHEBI:16646" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate" ; rdfs:subClassOf obo:CHEBI_78616 . obo:CHEBI_16651 obo:IAO_0000115 "An optically active form of lactate having (S)-configuration." ; chebi:charge "-1" ; chebi:formula "C3H5O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1" ; chebi:inchikey "JVTAAEKCZFNVCJ-REOHCLBHSA-M" ; chebi:mass "89.07000" ; chebi:monoisotopicmass "89.02442" ; chebi:smiles "C[C@H](O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11065", "CHEBI:12411", "CHEBI:18783" ; oboInOwl:hasDbXref "Beilstein:4655977", "Gmelin:324523", "KEGG:C00186", "MetaCyc:L-LACTATE", "Reaxys:4655977", "UM-BBD_compID:c0152" ; oboInOwl:hasExactSynonym "(2S)-2-hydroxypropanoate", "(S)-lactate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-lactate", "L(+)-lactate", "L-(+)-lactate", "L-lactate" ; oboInOwl:id "CHEBI:16651" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-lactate" ; rdfs:subClassOf obo:CHEBI_24996, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_422 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16004 ] . obo:CHEBI_16670 obo:IAO_0000115 "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ; chebi:charge "0" ; chebi:formula "(C2H2NOR)nC2H3NOR" ; oboInOwl:hasAlternativeId "CHEBI:14753", "CHEBI:25906", "CHEBI:7990" ; oboInOwl:hasDbXref "KEGG:C00012" ; oboInOwl:hasExactSynonym "Peptide", "peptides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Peptid", "peptido", "peptidos" ; oboInOwl:id "CHEBI:16670" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "peptide" ; rdfs:subClassOf obo:CHEBI_37622, obo:CHEBI_50047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33708 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_60466 ] . obo:CHEBI_166902 chebi:charge "+1" ; chebi:formula "C8H12NO3" ; chebi:inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1" ; chebi:inchikey "SFLSHLFXELFNJZ-UHFFFAOYSA-O" ; chebi:mass "170.187" ; chebi:monoisotopicmass "170.08117" ; chebi:smiles "C1=CC(=CC(=C1O)O)C(C[NH3+])O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "noradrenaline" ; oboInOwl:id "CHEBI:166902" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "noradrenaline(1+)" ; rdfs:subClassOf obo:CHEBI_25697, obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33569 ] . obo:CHEBI_16708 obo:IAO_0000115 "The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6." ; chebi:charge "0" ; chebi:formula "C5H5N5" ; chebi:inchi "InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)" ; chebi:inchikey "GFFGJBXGBJISGV-UHFFFAOYSA-N" ; chebi:mass "135.12690" ; chebi:monoisotopicmass "135.05450" ; chebi:smiles "Nc1ncnc2[nH]cnc12" ; oboInOwl:hasAlternativeId "CHEBI:13733", "CHEBI:22236", "CHEBI:2470", "CHEBI:40579" ; oboInOwl:hasDbXref "Beilstein:608603", "CAS:73-24-5", "DrugBank:DB00173", "Drug_Central:89", "Gmelin:3903", "HMDB:HMDB0000034", "KEGG:C00147", "KEGG:D00034", "KNApSAcK:C00001490", "MetaCyc:ADENINE", "PDBeChem:ADE", "PMID:11985597", "PMID:12829005", "PMID:12951489", "PMID:15063338", "PMID:15715490", "PMID:17439666", "PMID:8070089", "Reaxys:608603", "Wikipedia:Adenine" ; oboInOwl:hasExactSynonym "9H-purin-6-amine", "ADENINE", "Adenine", "adenine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "6-Aminopurine", "A", "Ade", "Adenin" ; oboInOwl:id "CHEBI:16708" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "adenine" ; rdfs:subClassOf obo:CHEBI_20706, obo:CHEBI_26386, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35589 ] . obo:CHEBI_167114 obo:IAO_0000115 "Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group. Major species at pH 7.3." ; chebi:charge "-2" ; chebi:formula "C3HO5R2" ; chebi:mass "117.037" ; chebi:monoisotopicmass "116.98240" ; chebi:smiles "C(C(*C([O-])=O)(O)*)([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a 2-hydroxydicarboxylate" ; oboInOwl:id "CHEBI:167114" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "2-hydroxydicarboxylate(2-)" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_50263 ] . obo:CHEBI_16716 obo:IAO_0000115 "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." ; chebi:charge "0" ; chebi:formula "C6H6" ; chebi:inchi "InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H" ; chebi:inchikey "UHOVQNZJYSORNB-UHFFFAOYSA-N" ; chebi:mass "78.11184" ; chebi:monoisotopicmass "78.04695" ; chebi:smiles "c1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:13876", "CHEBI:22703", "CHEBI:3025", "CHEBI:41187" ; oboInOwl:hasDbXref "Beilstein:969212", "CAS:71-43-2", "Gmelin:1671", "HMDB:HMDB0001505", "KEGG:C01407", "PDBeChem:BNZ", "PMID:11684179", "PMID:11993966", "PMID:12857942", "PMID:14677922", "PMID:15468289", "PMID:15935818", "PMID:16161967", "PMID:17373369", "PMID:18072742", "PMID:18407866", "PMID:18409691", "PMID:18836923", "PMID:19228219", "PMID:21325737", "PMID:23088855", "PMID:23222815", "PMID:23534829", "PMID:6353911", "PMID:8124204", "Reaxys:969212", "UM-BBD_compID:c0142", "Wikipedia:Benzene" ; oboInOwl:hasExactSynonym "BENZENE", "Benzene", "benzene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Benzen", "Benzine", "Benzol", "Bicarburet of hydrogen", "Coal naphtha", "Mineral naphtha", "Phene", "Pyrobenzol", "Pyrobenzole", "[6]annulene", "benzole", "cyclohexatriene", "phenyl hydride" ; oboInOwl:id "CHEBI:16716" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzene" ; rdfs:subClassOf obo:CHEBI_134179, obo:CHEBI_22712, obo:CHEBI_33842, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50903 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78298 ] . obo:CHEBI_16733 chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.05870" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "N[C@H]([*])C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:12909", "CHEBI:13625", "CHEBI:20906", "CHEBI:4097" ; oboInOwl:hasDbXref "KEGG:C00405" ; oboInOwl:hasExactSynonym "D-alpha-amino acid", "D-alpha-amino acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-Amino acid", "D-alpha-amino acids" ; oboInOwl:id "CHEBI:16733" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_60895 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_59871 ] . obo:CHEBI_16737 obo:IAO_0000115 "A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine." ; chebi:charge "0" ; chebi:formula "C4H7N3O" ; chebi:inchi "InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)" ; chebi:inchikey "DDRJAANPRJIHGJ-UHFFFAOYSA-N" ; chebi:mass "113.11800" ; chebi:monoisotopicmass "113.05891" ; chebi:smiles "CN1CC(=O)NC1=N" ; oboInOwl:hasAlternativeId "CHEBI:14029", "CHEBI:23406", "CHEBI:3910" ; oboInOwl:hasDbXref "CAS:60-27-5", "HMDB:HMDB0000562", "KEGG:C00791", "KEGG:D03600", "MetaCyc:CREATININE", "PMID:11256540", "PMID:11981083", "PMID:17190852", "PMID:17422601", "PMID:18182718", "PMID:19236048", "PMID:19715855", "PMID:19968328", "PMID:21775764", "PMID:22047975", "PMID:22121923", "PMID:22166252", "PMID:22207347", "PMID:22212624", "PMID:22223530", "PMID:22331238", "PMID:22338083", "PMID:22349552", "PMID:22390548", "PMID:22432114", "PMID:22441184", "PMID:22459582", "PMID:22498455", "Reaxys:112064", "Wikipedia:Creatinine" ; oboInOwl:hasExactSynonym "2-imino-1-methylimidazolidin-4-one", "Creatinine", "creatinine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-Methylglycocyamidine", "1-Methylhydantoin-2-imide", "1-methylglycocyamidine", "2-Amino-1-methylimidazolin-4-one", "2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-one", "Creatine anhydride", "Kreatinin", "creatinina" ; oboInOwl:id "CHEBI:16737" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "creatinine" ; rdfs:subClassOf obo:CHEBI_24995, obo:CHEBI_55370, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33295 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16919 ] . obo:CHEBI_16742 obo:IAO_0000115 "A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6." ; chebi:charge "0" ; chebi:formula "C5H4N2O4" ; chebi:inchi "InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)" ; chebi:inchikey "PXQPEWDEAKTCGB-UHFFFAOYSA-N" ; chebi:mass "156.09630" ; chebi:monoisotopicmass "156.01711" ; chebi:smiles "OC(=O)c1cc(=O)[nH]c(=O)[nH]1" ; oboInOwl:hasAlternativeId "CHEBI:25720", "CHEBI:44781", "CHEBI:7787" ; oboInOwl:hasDbXref "Beilstein:383901", "CAS:65-86-1", "DrugBank:DB02262", "Drug_Central:3402", "Gmelin:101990", "HMDB:HMDB0000226", "KEGG:C00295", "KEGG:D00055", "KNApSAcK:C00019689", "MetaCyc:OROTATE", "PDBeChem:ORO", "PMID:11059538", "PMID:22019295", "PMID:22285839", "PMID:22307261", "PMID:22371390", "PMID:22634191", "PMID:22707164", "PMID:22770225", "PMID:22863860", "PMID:7264771", "Reaxys:383901", "Wikipedia:Orotic_acid" ; oboInOwl:hasExactSynonym "2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid", "OROTIC ACID", "Orotic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Orotsaeure", "Uracil-6-carboxylic acid" ; oboInOwl:id "CHEBI:16742" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "orotic acid" ; rdfs:subClassOf obo:CHEBI_26447, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17568 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30839 ] . obo:CHEBI_167559 obo:IAO_0000115 "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycans" ; oboInOwl:id "CHEBI:167559" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycan" ; rdfs:subClassOf obo:CHEBI_78616 . obo:CHEBI_16765 obo:IAO_0000115 "An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position." ; chebi:charge "0" ; chebi:formula "C10H12N2" ; chebi:inchi "InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2" ; chebi:inchikey "APJYDQYYACXCRM-UHFFFAOYSA-N" ; chebi:mass "160.21570" ; chebi:monoisotopicmass "160.10005" ; chebi:smiles "NCCc1c[nH]c2ccccc12" ; oboInOwl:hasAlternativeId "CHEBI:15274", "CHEBI:27161", "CHEBI:46157", "CHEBI:9767" ; oboInOwl:hasDbXref "Beilstein:125513", "CAS:61-54-1", "DrugBank:DB08653", "Gmelin:603448", "HMDB:HMDB0000303", "KEGG:C00398", "KNApSAcK:C00001434", "MetaCyc:TRYPTAMINE", "PDBeChem:TSS", "PMID:16126914", "PMID:22770225", "PMID:24345948", "PMID:24558969", "Reaxys:125513", "Wikipedia:Tryptamine" ; oboInOwl:hasExactSynonym "2-(1H-indol-3-yl)ethanamine", "Tryptamine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1H-indole-3-ethanamine", "2-(1H-INDOL-3-YL)ETHANAMINE", "2-(3-indolyl)ethylamine", "3-(2-Aminoethyl)indole" ; oboInOwl:id "CHEBI:16765" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptamine" ; rdfs:subClassOf obo:CHEBI_27162, obo:CHEBI_38631, obo:CHEBI_38958, obo:CHEBI_64365, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_57887 ] . obo:CHEBI_16782 obo:IAO_0000115 "A 2-hydroxyglutarate(2-) that has (2S)-configuration." ; chebi:charge "-2" ; chebi:formula "C5H6O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/p-2/t3-/m0/s1" ; chebi:inchikey "HWXBTNAVRSUOJR-VKHMYHEASA-L" ; chebi:mass "146.09814" ; chebi:monoisotopicmass "146.02262" ; chebi:smiles "O[C@@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11036", "CHEBI:18738" ; oboInOwl:hasDbXref "Beilstein:5257108", "KEGG:C03196", "MetaCyc:CPD-381", "Reaxys:5257108" ; oboInOwl:hasExactSynonym "(2S)-2-hydroxypentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-hydroxyglutarate" ; oboInOwl:id "CHEBI:16782" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-2-hydroxyglutarate(2-)" ; rdfs:subClassOf obo:CHEBI_11596, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32797 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_15801 ] . obo:CHEBI_16810 obo:IAO_0000115 "An oxo dicarboxylate obtained by deprotonation of both carboxy groups of 2-oxoglutaric acid." ; chebi:charge "-2" ; chebi:formula "C5H4O5" ; chebi:inchi "InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2" ; chebi:inchikey "KPGXRSRHYNQIFN-UHFFFAOYSA-L" ; chebi:mass "144.08226" ; chebi:monoisotopicmass "144.00697" ; chebi:smiles "[O-]C(=O)CCC(=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11638", "CHEBI:19748" ; oboInOwl:hasDbXref "Beilstein:3664503", "CAS:64-15-3", "Gmelin:602479", "KEGG:C00026", "MetaCyc:2-KETOGLUTARATE", "PMID:11913971", "PMID:15612731", "PMID:17190852", "PMID:19376872", "PMID:21184277", "PMID:21196226", "PMID:21791173", "PMID:24828042", "Reaxys:3664503" ; oboInOwl:hasExactSynonym "2-oxopentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ketoglutarate", "2-oxoglutarate", "2-oxopentanedioic acid, ion(2-)", "alpha-ketoglutarate" ; oboInOwl:id "CHEBI:16810" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-oxoglutarate(2-)" ; rdfs:subClassOf obo:CHEBI_36147, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_176497 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30921 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30916 ] . obo:CHEBI_16811 obo:IAO_0000115 "A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4." ; chebi:charge "0" ; chebi:formula "C5H11NO2S" ; chebi:inchi "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)" ; chebi:inchikey "FFEARJCKVFRZRR-UHFFFAOYSA-N" ; chebi:mass "149.21238" ; chebi:monoisotopicmass "149.05105" ; chebi:smiles "CSCCC(N)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14590", "CHEBI:25229", "CHEBI:6829" ; oboInOwl:hasDbXref "Beilstein:636185", "CAS:59-51-8", "Gmelin:3117", "KEGG:C01733", "KEGG:D04983", "PMID:16702333", "PMID:22264337", "PMID:2543976", "Reaxys:636185", "UM-BBD_compID:c0094", "Wikipedia:Methionine" ; oboInOwl:hasExactSynonym "Methionine", "methionine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-4-(methylthio)butyric acid", "2-amino-4-(methylsulfanyl)butanoic acid", "2-amino-4-(methylthio)butanoic acid", "DL-Methionine", "Hmet", "M", "Met", "Methionin", "Racemethionine", "alpha-amino-gamma-methylmercaptobutyric acid", "metionina" ; oboInOwl:id "CHEBI:16811" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methionine" ; rdfs:subClassOf obo:CHEBI_26834, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32644 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32646 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_64558 ] . obo:CHEBI_16813 obo:IAO_0000115 "An optically inactive hexitol having meso-configuration." ; chebi:charge "0" ; chebi:formula "C6H14O6" ; chebi:inchi "InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-" ; chebi:inchikey "FBPFZTCFMRRESA-GUCUJZIJSA-N" ; chebi:mass "182.17180" ; chebi:monoisotopicmass "182.07904" ; chebi:smiles "OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:14286", "CHEBI:24139", "CHEBI:5251", "CHEBI:53575" ; oboInOwl:hasDbXref "Beilstein:1721903", "CAS:608-66-2", "Gmelin:83163", "HMDB:HMDB0000107", "KEGG:C01697", "KNApSAcK:C00001160", "PMID:16664750", "PMID:16901854", "PMID:17336832", "PMID:17979222", "PMID:21501963", "PMID:22155165", "PMID:22628202", "PMID:22654107", "PMID:23830453", "PMID:24643482", "Reaxys:1721903", "Wikipedia:Galactitol" ; oboInOwl:hasExactSynonym "Galactitol", "galactitol", "meso-galactitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol", "D-Dulcitol", "D-galactitol", "Dulcitol", "Dulcose", "Euonymit", "L-galactitol", "Melampyrin", "Melampyrit" ; oboInOwl:id "CHEBI:16813" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactitol" ; rdfs:subClassOf obo:CHEBI_24583, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_16827 obo:IAO_0000115 "A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands." ; chebi:charge "0" ; chebi:formula "C21H30O4" ; chebi:inchi "InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1" ; chebi:inchikey "OMFXVFTZEKFJBZ-HJTSIMOOSA-N" ; chebi:mass "346.46050" ; chebi:monoisotopicmass "346.21441" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO" ; oboInOwl:hasAlternativeId "CHEBI:14022", "CHEBI:19131", "CHEBI:3891", "CHEBI:41361", "CHEBI:57911" ; oboInOwl:hasDbXref "Beilstein:2339601", "CAS:50-22-6", "HMDB:HMDB0001547", "KEGG:C02140", "LINCS:LSM-5814", "LIPID_MAPS_instance:LMST02030186", "MetaCyc:CORTICOSTERONE", "PDBeChem:C0R", "PMID:10438974", "PMID:11448093", "PMID:16817814", "PMID:24446162", "Wikipedia:Corticosterone" ; oboInOwl:hasExactSynonym "11beta,21-dihydroxypregn-4-ene-3,20-dione", "CORTICOSTERONE", "Corticosterone", "corticosterone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione", "11beta,21-Dihydroxy-4-pregnene-3,20-dione", "11beta,21-dihydroxyprogesterone", "17-deoxycortisol", "Kendall's compound B", "Reichstein's substance H" ; oboInOwl:id "CHEBI:16827" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "corticosterone" ; rdfs:subClassOf obo:CHEBI_139590, obo:CHEBI_24261, obo:CHEBI_35344, obo:CHEBI_35346, obo:CHEBI_36885, obo:CHEBI_47909, obo:CHEBI_61313, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_8386 ] . obo:CHEBI_16831 obo:IAO_0000115 "A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura." ; chebi:charge "0" ; chebi:formula "C6H10O5" ; chebi:inchi "InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)" ; chebi:inchikey "NPOAOTPXWNWTSH-UHFFFAOYSA-N" ; chebi:mass "162.14060" ; chebi:monoisotopicmass "162.05282" ; chebi:smiles "CC(O)(CC(O)=O)CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:11044", "CHEBI:1524", "CHEBI:18746", "CHEBI:20043", "CHEBI:391", "CHEBI:43804" ; oboInOwl:hasDbXref "Beilstein:1769194", "CAS:503-49-1", "DrugBank:DB04377", "Drug_Central:1670", "HMDB:HMDB0000355", "KEGG:C03761", "KEGG:D04897", "KNApSAcK:C00001187", "MetaCyc:CPD-547", "PDBeChem:MAH", "PMID:10916782", "PMID:17941049", "PMID:3063529", "PMID:4717513", "PMID:6083597", "PMID:9658458", "Reaxys:1769194" ; oboInOwl:hasExactSynonym "3-hydroxy-3-methylpentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-3-Hydroxy-3-methylglutaric acid", "(S)-Meglutol", "3-HYDROXY-3-METHYL-GLUTARIC ACID", "3-Hydroxy-3-methylpentanedioic acid", "Dicrotalic acid", "beta-Hydroxy-beta-methylglutaric acid", "beta-hydroxy-beta-methylglutaric acid", "meglutol", "meglutolum" ; oboInOwl:id "CHEBI:16831" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy-3-methylglutaric acid" ; rdfs:subClassOf obo:CHEBI_26878, obo:CHEBI_35692, obo:CHEBI_61355, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35221 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35664 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35821 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17859 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30920 ] . obo:CHEBI_16865 obo:IAO_0000115 "A gamma-amino acid that is butanoic acid with the amino substituent located at C-4." ; chebi:charge "0" ; chebi:formula "C4H9NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)" ; chebi:inchikey "BTCSSZJGUNDROE-UHFFFAOYSA-N" ; chebi:mass "103.11980" ; chebi:monoisotopicmass "103.06333" ; chebi:smiles "NCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:1786", "CHEBI:193777", "CHEBI:20318", "CHEBI:40483" ; oboInOwl:hasDbXref "BPDB:2298", "Beilstein:906818", "CAS:56-12-2", "DrugBank:DB02530", "Drug_Central:1262", "Gmelin:49775", "HMDB:HMDB0000112", "KEGG:C00334", "KEGG:D00058", "KNApSAcK:C00001337", "LIPID_MAPS_instance:LMFA01100039", "MetaCyc:4-AMINO-BUTYRATE", "PDBeChem:ABU", "PMID:10630630", "PMID:10930630", "PMID:16276116", "PMID:21614609", "PMID:22770225", "Reaxys:906818", "Wikipedia:Gamma-Aminobutyric_acid" ; oboInOwl:hasExactSynonym "4-aminobutanoic acid", "gamma-Aminobutyric acid", "gamma-aminobutyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-Aminobutanoic acid", "4-Aminobutyric acid", "4-aminobutanoic acid", "4-aminobutyric acid", "4Abu", "GABA", "GAMMA-AMINO-BUTANOIC ACID", "gamma-Aminobuttersaeure", "gamma-amino-n-butyric acid", "gamma-aminobutanoic acid", "omega-aminobutyric acid", "piperidic acid", "piperidinic acid" ; oboInOwl:id "CHEBI:16865" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-aminobutyric acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_33707, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_62488 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30566 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_59888 ] . obo:CHEBI_16919 obo:IAO_0000115 "A glycine derivative having methyl and amidino groups attached to the nitrogen." ; chebi:charge "0" ; chebi:formula "C4H9N3O2" ; chebi:inchi "InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)" ; chebi:inchikey "CVSVTCORWBXHQV-UHFFFAOYSA-N" ; chebi:mass "131.13328" ; chebi:monoisotopicmass "131.06948" ; chebi:smiles "CN(CC(O)=O)C(N)=N" ; oboInOwl:hasAlternativeId "CHEBI:14028", "CHEBI:23404", "CHEBI:3909", "CHEBI:41678" ; oboInOwl:hasDbXref "Beilstein:907175", "CAS:57-00-1", "Chemspider:566", "DrugBank:DB00148", "Drug_Central:4661", "Gmelin:240513", "HMDB:HMDB0000064", "KEGG:C00300", "MetaCyc:CREATINE", "PDBeChem:CRN", "PMID:11356982", "PMID:11483809", "PMID:11867929", "PMID:12085493", "PMID:12184144", "PMID:12878267", "PMID:16445883", "PMID:17190852", "PMID:17253521", "PMID:17416441", "PMID:18555535", "PMID:19082141", "PMID:19651674", "PMID:19741514", "PMID:19968328", "PMID:21556832", "PMID:21660517", "PMID:21698493", "PMID:22038587", "PMID:22101931", "PMID:22196490", "PMID:22252611", "PMID:22347384", "PMID:22386973", "PMID:22422801", "PMID:22429992", "PMID:22465051", "PMID:22521466", "PMID:7752905", "Reaxys:907175", "Wikipedia:Creatine" ; oboInOwl:hasExactSynonym "Creatine", "N-[amino(imino)methyl]-N-methylglycine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "((amino(imino)methyl)(methyl)amino)acetic acid", "(N-methylcarbamimidamido)acetic acid", "(alpha-methylguanido)acetic acid", "Creatin", "Kreatin", "Methylglycocyamine", "N-(aminoiminomethyl)-N-methylglycine", "N-Methyl-N-guanylglycine", "N-[(E)-AMINO(IMINO)METHYL]-N-METHYLGLYCINE", "N-amidinosarcosine", "N-carbamimidoyl-N-methylglycine", "N-methyl-N-guanylglycine", "alpha-Methylguanidino acetic acid" ; oboInOwl:id "CHEBI:16919" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "creatine" ; rdfs:subClassOf obo:CHEBI_24373, obo:CHEBI_24436, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_176497 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_63726 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57947 ] . obo:CHEBI_16924 obo:IAO_0000115 "The D-enantiomer of 5-oxoproline." ; chebi:charge "0" ; chebi:formula "C5H7NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m1/s1" ; chebi:inchikey "ODHCTXKNWHHXJC-GSVOUGTGSA-N" ; chebi:mass "129.11400" ; chebi:monoisotopicmass "129.04259" ; chebi:smiles "OC(=O)[C@H]1CCC(=O)N1" ; oboInOwl:hasAlternativeId "CHEBI:12152", "CHEBI:20618", "CHEBI:2112" ; oboInOwl:hasDbXref "Beilstein:82133", "CAS:4042-36-8", "DrugBank:DB03088", "Gmelin:1473408", "HMDB:HMDB0000267", "KEGG:C02237", "MetaCyc:CPD-656", "PMID:22770225", "Reaxys:82133" ; oboInOwl:hasExactSynonym "(2R)-5-oxopyrrolidine-2-carboxylic acid", "5-Oxo-D-proline", "5-oxo-D-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-5-Pyrrolidone-2-carboxylic acid", "D-Pyroglutamic acid" ; oboInOwl:id "CHEBI:16924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxo-D-proline" ; rdfs:subClassOf obo:CHEBI_16010, obo:CHEBI_84185, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57948 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_18183 ] . obo:CHEBI_16947 obo:IAO_0000115 "A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid." ; chebi:charge "-3" ; chebi:formula "C6H5O7" ; chebi:inchi "InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3" ; chebi:inchikey "KRKNYBCHXYNGOX-UHFFFAOYSA-K" ; chebi:mass "189.09970" ; chebi:monoisotopicmass "189.00517" ; chebi:smiles "OC(CC([O-])=O)(CC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13999", "CHEBI:23321", "CHEBI:42563" ; oboInOwl:hasDbXref "Beilstein:1884707", "CAS:126-44-3", "Gmelin:4239", "KEGG:C00158", "PDBeChem:FLC", "Reaxys:1884707" ; oboInOwl:hasExactSynonym "2-hydroxypropane-1,2,3-tricarboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxy-1,2,3-propanetricarboxylate", "2-hydroxy-1,2,3-propanetricarboxylate(3-)", "2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-)", "2-hydroxytricarballylate", "CITRATE ANION", "cit", "cit(3-)", "citrate" ; oboInOwl:id "CHEBI:16947" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrate(3-)" ; rdfs:subClassOf obo:CHEBI_133748, obo:CHEBI_27092, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132362 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35808 ] . obo:CHEBI_16958 obo:IAO_0000115 "A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)" ; chebi:inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-N" ; chebi:mass "89.09322" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "NCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10343", "CHEBI:12389", "CHEBI:22821", "CHEBI:41050" ; oboInOwl:hasDbXref "Beilstein:906793", "CAS:107-95-9", "DrugBank:DB03107", "Gmelin:49614", "HMDB:HMDB0000056", "KEGG:C00099", "KEGG:D07561", "KNApSAcK:C00001333", "MetaCyc:B-ALANINE", "PDBeChem:BAL", "PMID:11139233", "PMID:11850512", "PMID:12107759", "PMID:12887142", "PMID:14363188", "PMID:16934791", "PMID:18528519", "PMID:18613640", "PMID:19239140", "PMID:19955842", "PMID:20199122", "PMID:20386120", "PMID:20479615", "PMID:20994958", "PMID:22735334", "Reaxys:906793", "Wikipedia:Beta-Alanine" ; oboInOwl:hasExactSynonym "3-aminopropanoic acid", "BETA-ALANINE", "beta-Alanine", "beta-alanine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-Aminopropionic acid", "3-aminopropanoic acid", "H-beta-Ala-OH", "bAla", "beta-aminopropionic acid", "omega-aminopropionic acid" ; oboInOwl:id "CHEBI:16958" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-alanine" ; rdfs:subClassOf obo:CHEBI_33706, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35222 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48705 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63070 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_57966 ] . obo:CHEBI_16990 obo:IAO_0000115 "A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." ; chebi:charge "0" ; chebi:formula "C33H36N4O6" ; chebi:inchi "InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-" ; chebi:inchikey "BPYKTIZUTYGOLE-IFADSCNNSA-N" ; chebi:mass "584.673" ; chebi:monoisotopicmass "584.26348" ; chebi:smiles "CC1=C(C=C)\\C(NC1=O)=C\\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\\C=C2/NC(=O)C(C=C)=C2C)N1" ; oboInOwl:hasAlternativeId "CHEBI:13898", "CHEBI:22870", "CHEBI:3099" ; oboInOwl:hasDbXref "Beilstein:74376", "CAS:635-65-4", "Gmelin:411033", "HMDB:HMDB0000054", "KEGG:C00486", "KNApSAcK:C00029828", "MetaCyc:BILIRUBIN", "PDBeChem:BLR", "PMID:12799017", "PMID:18442622", "PMID:23763371", "PMID:23768684", "PMID:30224965", "PMID:8605219", "PMID:9587403", "Reaxys:74376", "Wikipedia:Bilirubin" ; oboInOwl:hasExactSynonym "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid", "bilirubin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid", "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid", "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid", "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione", "Bilirubin", "bilirubin(Z,Z)", "bilirubin-IXalpha" ; oboInOwl:id "CHEBI:16990" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bilirubin IXalpha" ; rdfs:subClassOf obo:CHEBI_35692, obo:CHEBI_36735, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_142163 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_57977 ] . obo:CHEBI_16995 obo:IAO_0000115 "An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2." ; chebi:charge "0" ; chebi:formula "C2H2O4" ; chebi:inchi "InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)" ; chebi:inchikey "MUBZPKHOEPUJKR-UHFFFAOYSA-N" ; chebi:mass "90.03490" ; chebi:monoisotopicmass "89.99531" ; chebi:smiles "OC(=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:25730", "CHEBI:44583", "CHEBI:7811" ; oboInOwl:hasDbXref "Beilstein:385686", "CAS:144-62-7", "DrugBank:DB03902", "Gmelin:2208", "HMDB:HMDB0002329", "KEGG:C00209", "KNApSAcK:C00001198", "LIPID_MAPS_instance:LMFA01170031", "MetaCyc:OXALATE", "PDBeChem:OXD", "PMID:15587083", "PMID:22735334", "Reaxys:385686", "Wikipedia:Oxalic_acid" ; oboInOwl:hasExactSynonym "OXALIC ACID", "Oxalic acid", "oxalic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Ethandisaeure", "Ethanedioic acid", "H2ox", "HOOCCOOH", "Oxalsaeure", "ethane-1,2-dioic acid" ; oboInOwl:id "CHEBI:16995" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxalic acid" ; rdfs:subClassOf obo:CHEBI_28383, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132952 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_46904 ] . obo:CHEBI_16997 obo:IAO_0000115 "The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze." ; chebi:charge "0" ; chebi:formula "C3H8O2" ; chebi:inchi "InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3" ; chebi:inchikey "DNIAPMSPPWPWGF-UHFFFAOYSA-N" ; chebi:mass "76.09442" ; chebi:monoisotopicmass "76.05243" ; chebi:smiles "CC(O)CO" ; oboInOwl:hasAlternativeId "CHEBI:14899", "CHEBI:8469" ; oboInOwl:hasDbXref "CAS:57-55-6", "DrugBank:DB01839", "Drug_Central:4024", "HMDB:HMDB0001881", "KEGG:C00583", "KEGG:D00078", "KNApSAcK:C00007410", "LINCS:LSM-36856", "PMID:15665701", "PMID:16078503", "PMID:18346395", "PMID:18845115", "PMID:21616561", "PPDB:1304", "Reaxys:1340498", "VSDB:1304", "Wikipedia:Propylene_glycol" ; oboInOwl:hasExactSynonym "Propane-1,2-diol", "propane-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,2-Propanediol", "1,2-Propylenglykol", "1,2-dihydroxypropane", "2-hydroxypropanol", "CH3CH(OH)CH2OH", "HOCH2CH(OH)CH3", "HOCH2CH(OH)Me", "MeCH(OH)CH2OH", "PPD", "Propylene glycol", "alpha-propyleneglycol", "isopropylene glycol", "methyl glycol", "methylethyl glycol", "methylethylene glycol", "monopropylene glycol" ; oboInOwl:id "CHEBI:16997" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "propane-1,2-diol" ; rdfs:subClassOf obo:CHEBI_13643, obo:CHEBI_26284, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48356 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50904 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ] . obo:CHEBI_17002 obo:IAO_0000115 "A sterol ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of cholesterol." ; chebi:charge "0" ; chebi:formula "C28H45O2R" ; chebi:mass "413.65570" ; chebi:monoisotopicmass "413.34196" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC([*])=O)[C@H](C)CCCC(C)C" ; oboInOwl:hasAlternativeId "CHEBI:13983", "CHEBI:23205", "CHEBI:3660" ; oboInOwl:hasDbXref "KEGG:C02530", "PMID:2474544" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Cholesterol ester", "a cholesterol ester", "cholesterol esters", "cholesteryl esters" ; oboInOwl:id "CHEBI:17002" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholesteryl ester" ; rdfs:subClassOf obo:CHEBI_35915, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16113 ] . obo:CHEBI_17012 obo:IAO_0000115 "An N-acylneuraminic acid where the N-acyl group is specified as acetyl." ; chebi:charge "0" ; chebi:formula "C11H19NO9" ; chebi:inchi "InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11?/m0/s1" ; chebi:inchikey "SQVRNKJHWKZAKO-LUWBGTNYSA-N" ; chebi:mass "309.26990" ; chebi:monoisotopicmass "309.10598" ; chebi:smiles "[H][C@]1(OC(O)(C[C@H](O)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:21620", "CHEBI:7214" ; oboInOwl:hasDbXref "Beilstein:2951361", "CAS:131-48-6", "GlyGen:G81533KY", "GlyTouCan:G81533KY", "KEGG:C00270", "KNApSAcK:C00019584", "PMID:14960498", "PMID:16209099", "PMID:16624269", "PMID:18487279", "PMID:19329108", "PMID:7508418", "PMID:8448384", "Reaxys:1398688", "Wikipedia:N-acetylneuraminic_acid" ; oboInOwl:hasExactSynonym "5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid", "N-Acetylneuraminic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid", "Aceneuramic acid", "Neu5Ac", "NeuAc", "O-sialic acid", "WURCS=2.0/1,1,0/[Aad21122h-2x_2-6_5*NCC/3=O]/1/", "aceneuramic acid", "acide aceneuramique", "acidium aceneuramicum", "acido aceneuramico" ; oboInOwl:id "CHEBI:17012" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetylneuraminic acid" ; rdfs:subClassOf obo:CHEBI_21622, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_52425 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76969 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35418 ] . obo:CHEBI_17026 obo:IAO_0000115 "A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species." ; chebi:charge "0" ; chebi:formula "C21H30O2" ; chebi:inchi "InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1" ; chebi:inchikey "RJKFOVLPORLFTN-LEKSSAKUSA-N" ; chebi:mass "314.46170" ; chebi:monoisotopicmass "314.22458" ; chebi:smiles "[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O" ; oboInOwl:hasAlternativeId "CHEBI:14896", "CHEBI:18798", "CHEBI:26269", "CHEBI:439", "CHEBI:45786", "CHEBI:8453" ; oboInOwl:hasDbXref "Beilstein:1915950", "CAS:57-83-0", "DrugBank:DB00396", "Drug_Central:2279", "Gmelin:708590", "HMDB:HMDB0001830", "KEGG:C00410", "KEGG:D00066", "MetaCyc:PROGESTERONE", "PDBeChem:STR", "PMID:10438974", "PMID:9506942", "Reaxys:1915950", "Wikipedia:Progesterone" ; oboInOwl:hasExactSynonym "PROGESTERONE", "Progesterone", "pregn-4-ene-3,20-dione", "progesterone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-4-Pregnene-3,20-dione", "(S)-Pregn-4-en-3,20-dione", "(S)-Progesterone", "17alpha-progesterone", "4-Pregnene-3,20-dione", "Agolutin", "Akrolutin", "Crinone", "Delta(4)-pregnene-3,20-dione", "Gelbkoerperhormon", "Progesteron", "corpus luteum hormone", "luteohormone" ; oboInOwl:id "CHEBI:17026" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "progesterone" ; rdfs:subClassOf obo:CHEBI_36885, obo:CHEBI_47909, obo:CHEBI_64600, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_49323 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59826 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_70709 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_8386 ] . obo:CHEBI_17053 obo:IAO_0000115 "The L-enantiomer of aspartic acid." ; chebi:charge "0" ; chebi:formula "C4H7NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-REOHCLBHSA-N" ; chebi:mass "133.10270" ; chebi:monoisotopicmass "133.03751" ; chebi:smiles "N[C@@H](CC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:21247", "CHEBI:40853", "CHEBI:40900", "CHEBI:40913", "CHEBI:40942", "CHEBI:6193" ; oboInOwl:hasDbXref "Beilstein:1723530", "CAS:56-84-8", "DrugBank:DB00128", "Drug_Central:1550", "ECMDB:ECMDB00191", "Gmelin:3333", "HMDB:HMDB0000191", "KEGG:C00049", "KEGG:D00013", "KNApSAcK:C00001342", "MetaCyc:L-ASPARTATE", "PDBeChem:ASP", "PMID:11568288", "PMID:21359215", "PMID:22770225", "Reaxys:1723530", "YMDB:YMDB00896" ; oboInOwl:hasExactSynonym "(2S)-2-aminobutanedioic acid", "L-Aspartic acid", "L-aspartic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-aminobutanedioic acid", "(S)-2-aminosuccinic acid", "2-Aminosuccinic acid", "ASPARTIC ACID", "Asp", "D", "L-Asparaginsaeure" ; oboInOwl:id "CHEBI:17053" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-aspartic acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_22658, obo:CHEBI_22660, obo:CHEBI_83813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29991 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17364 ] . obo:CHEBI_17062 chebi:charge "0" ; chebi:formula "CH4NR" ; chebi:mass "30.04920" ; chebi:monoisotopicmass "30.03437" ; chebi:smiles "NC[*]" ; oboInOwl:hasAlternativeId "CHEBI:13431", "CHEBI:8749" ; oboInOwl:hasDbXref "KEGG:C00375" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "RCH2NH2", "primary aliphatic amines" ; oboInOwl:id "CHEBI:17062" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary aliphatic amine" ; rdfs:subClassOf obo:CHEBI_32877, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_58001 ] . obo:CHEBI_17084 obo:IAO_0000115 "A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group." ; chebi:charge "0" ; chebi:formula "C5H8O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)" ; chebi:inchikey "HWXBTNAVRSUOJR-UHFFFAOYSA-N" ; chebi:mass "148.11402" ; chebi:monoisotopicmass "148.03717" ; chebi:smiles "OC(CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:1160" ; oboInOwl:hasDbXref "Beilstein:1723805", "CAS:2889-31-8", "KEGG:C02630", "MetaCyc:2-HYDROXYGLUTARIC_ACID", "PMID:17439666", "Reaxys:1723805", "Wikipedia:Alpha-Hydroxyglutaric_acid" ; oboInOwl:hasExactSynonym "2-hydroxyglutaric acid", "2-hydroxypentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-hydroxyglutaric acid" ; oboInOwl:id "CHEBI:17084" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxyglutaric acid" ; rdfs:subClassOf obo:CHEBI_189840, obo:CHEBI_50263, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17859 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132941 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_36149 ] . obo:CHEBI_17087 obo:IAO_0000115 "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." ; chebi:charge "0" ; chebi:formula "COR2" ; chebi:mass "28.010" ; chebi:monoisotopicmass "27.99491" ; chebi:smiles "[*]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13427", "CHEBI:13646", "CHEBI:24974", "CHEBI:6127", "CHEBI:8742" ; oboInOwl:hasDbXref "KEGG:C01450", "Wikipedia:Ketone" ; oboInOwl:hasExactSynonym "Ketone", "ketones" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Keton", "R-CO-R'", "a ketone", "cetone", "ketones" ; oboInOwl:id "CHEBI:17087" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ketone" ; rdfs:subClassOf obo:CHEBI_36586 . obo:CHEBI_17089 obo:IAO_0000115 "A compound in which a carbohydrate component is covalently bound to a protein component." ; oboInOwl:hasAlternativeId "CHEBI:14349", "CHEBI:5481", "CHEBI:5493" ; oboInOwl:hasDbXref "KEGG:C00326" ; oboInOwl:hasExactSynonym "Glycoprotein", "glycoproteins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Glykoprotein", "Glykoproteine", "a glycoprotein", "glicoproteina", "glicoproteinas", "glycoproteine", "glycoproteines" ; oboInOwl:id "CHEBI:17089" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycoprotein" ; rdfs:subClassOf obo:CHEBI_33837, obo:CHEBI_63299 . obo:CHEBI_17113 obo:IAO_0000115 "The meso-diastereomer of butane-1,2,3,4-tetrol." ; chebi:charge "0" ; chebi:formula "C4H10O4" ; chebi:inchi "InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4+" ; chebi:inchikey "UNXHWFMMPAWVPI-ZXZARUISSA-N" ; chebi:mass "122.11980" ; chebi:monoisotopicmass "122.05791" ; chebi:smiles "OC[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:14215", "CHEBI:23946", "CHEBI:372804", "CHEBI:44263", "CHEBI:4840" ; oboInOwl:hasDbXref "Beilstein:1719753", "CAS:149-32-6", "DrugBank:DB04481", "Gmelin:82499", "HMDB:HMDB0002994", "KEGG:C00503", "KNApSAcK:C00001161", "MetaCyc:ERYTHRITOL", "PDBeChem:MRY", "PMCID:PMC9193570", "PMID:12639570", "PMID:163226", "PMID:16901854", "PMID:17336832", "PMID:17979222", "PMID:18369603", "PMID:19632091", "PMID:19804861", "PMID:22770225", "PMID:23421980", "PMID:23574577", "PMID:23890177", "PMID:24643482", "PMID:25108762", "PMID:35289142", "PMID:35364613", "PMID:35575772", "PMID:36276829", "PMID:36354105", "PMID:36478868", "PMID:36547619", "PMID:36615861", "PMID:36849732", "PMID:9862657", "Reaxys:1735878", "Wikipedia:Erythritol" ; oboInOwl:hasExactSynonym "Erythritol", "erythritol", "meso-erythritol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R,3S)-butane-1,2,3,4-tetrol", "Erythrit", "Erythrite", "Erythrol", "L-erythritol", "MESO-ERYTHRITOL", "Phycite", "Phycitol", "erythro-tetritol", "mesoerythritol" ; oboInOwl:id "CHEBI:17113" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "erythritol" ; rdfs:subClassOf obo:CHEBI_48299, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_17120 obo:IAO_0000115 "A short-chain fatty acid anion that is the conjugate base of hexanoic acid (also known as caproic acid)." ; chebi:charge "-1" ; chebi:formula "C6H11O2" ; chebi:inchi "InChI=1S/C6H12O2/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H,7,8)/p-1" ; chebi:inchikey "FUZZWVXGSFPDMH-UHFFFAOYSA-M" ; chebi:mass "115.15034" ; chebi:monoisotopicmass "115.07645" ; chebi:smiles "CCCCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14398", "CHEBI:24569" ; oboInOwl:hasDbXref "Beilstein:3601453", "CAS:151-33-7", "ECMDB:ECMDB21229", "Gmelin:326340", "KEGG:C01585", "MetaCyc:HEXANOATE" ; oboInOwl:hasExactSynonym "hexanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-hexanoate", "1-pentacarboxylate", "1-pentanecarboxylate", "CH3-[CH2]4-COO(-)", "butylacetate", "caproate", "capronate", "hexoate", "hexylate", "n-caproate", "n-hexanoate", "n-hexoate", "n-hexylate", "nPnCO2 anion", "pentanecarboxylate", "pentylformate" ; oboInOwl:id "CHEBI:17120" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexanoate" ; rdfs:subClassOf obo:CHEBI_58951, obo:CHEBI_58954, obo:CHEBI_78116, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30776 ] . obo:CHEBI_17126 obo:IAO_0000115 "An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4." ; chebi:charge "0" ; chebi:formula "C7H15NO3" ; chebi:inchi "InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3" ; chebi:inchikey "PHIQHXFUZVPYII-UHFFFAOYSA-N" ; chebi:mass "161.19894" ; chebi:monoisotopicmass "161.10519" ; chebi:smiles "C[N+](C)(C)CC(O)CC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11817", "CHEBI:13947", "CHEBI:20047", "CHEBI:23038" ; oboInOwl:hasDbXref "Beilstein:1866665", "CAS:461-06-3", "DrugBank:DB02648", "KEGG:C00487", "MetaCyc:DL-CARNITINE", "PMID:22770225", "PMID:23868375", "Patent:US4255449", "Patent:US4315944", "Reaxys:1866665", "Wikipedia:Carnitine" ; oboInOwl:hasExactSynonym "3-hydroxy-4-(trimethylammonio)butanoate", "carnitine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D,L-carnitine" ; oboInOwl:id "CHEBI:17126" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carnitine" ; rdfs:subClassOf obo:CHEBI_22860, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17968 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_3424 ] . obo:CHEBI_17137 chebi:charge "-1" ; chebi:formula "HO3S" ; chebi:inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1" ; chebi:inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-M" ; chebi:mass "81.07214" ; chebi:monoisotopicmass "80.96519" ; chebi:smiles "OS([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13367", "CHEBI:5598" ; oboInOwl:hasDbXref "CAS:15181-46-1", "Gmelin:1455", "KEGG:C11481", "PDBeChem:SO3" ; oboInOwl:hasExactSynonym "hydrogen(trioxidosulfate)(1-)", "hydrogensulfite(1-)", "hydrogentrioxosulfate(1-)", "hydrogentrioxosulfate(IV)", "hydroxidodioxidosulfate(1-)", "monohydrogentrioxosulfate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Bisulfite", "HSO3(-)", "HSO3-", "Hydrogen sulfite", "[SO2(OH)](-)", "bisulfite", "bisulphite", "hydrogen sulfite(1-)", "hydrosulfite anion" ; oboInOwl:id "CHEBI:17137" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogensulfite" ; rdfs:subClassOf obo:CHEBI_33482, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17359 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_48854 ] . obo:CHEBI_17151 obo:IAO_0000115 "A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group." ; chebi:charge "0" ; chebi:formula "C5H12O5" ; chebi:inchi "InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+" ; chebi:inchikey "HEBKCHPVOIAQTA-SCDXWVJYSA-N" ; chebi:mass "152.14580" ; chebi:monoisotopicmass "152.06847" ; chebi:smiles "OC[C@H](O)[C@@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:10078", "CHEBI:15328", "CHEBI:253147", "CHEBI:27339", "CHEBI:46522", "CHEBI:60939" ; oboInOwl:hasDbXref "Beilstein:1720523", "CAS:87-99-0", "DrugBank:DB01904", "Drug_Central:4604", "Gmelin:82893", "HMDB:HMDB0002917", "KEGG:C00379", "KEGG:D00061", "MetaCyc:XYLITOL", "PDBeChem:XYL", "PMID:11154411", "PMID:11163479", "PMID:12061879", "PMID:15377394", "PMID:16708791", "PMID:16901854", "PMID:17216457", "PMID:17216458", "PMID:17336832", "PMID:17979222", "PMID:18316079", "PMID:20030329", "PMID:22735334", "PMID:22791282", "PMID:23247825", "PMID:23287496", "PMID:23338824", "PMID:23589387", "PMID:23597921", "PMID:23615861", "PMID:23796483", "PMID:23916161", "PMID:23957303", "PMID:24012734", "PMID:24643482", "PMID:25108762", "Reaxys:1720523", "Wikipedia:Xylitol" ; oboInOwl:hasExactSynonym "(2R,3r,4S)-pentane-1,2,3,4,5-pentol", "Xylitol", "meso-xylitol", "xylitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R,3R,4S)-Pentane-1,2,3,4,5-pentaol", "D-XYLITOL", "L-xylitol", "Xylit", "xylite" ; oboInOwl:id "CHEBI:17151" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "xylitol" ; rdfs:subClassOf obo:CHEBI_25899, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50505 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50904 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59174 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ] . obo:CHEBI_17196 obo:IAO_0000115 "An optically active form of asparagine having L-configuration." ; chebi:charge "0" ; chebi:formula "C4H8N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-REOHCLBHSA-N" ; chebi:mass "132.11800" ; chebi:monoisotopicmass "132.05349" ; chebi:smiles "N[C@@H](CC(N)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:13083", "CHEBI:21242", "CHEBI:40902", "CHEBI:6191" ; oboInOwl:hasDbXref "Beilstein:1723527", "CAS:70-47-3", "DrugBank:DB00174", "Drug_Central:4126", "ECMDB:ECMDB00168", "FooDB:FDB000787", "Gmelin:3334", "HMDB:HMDB0000168", "KEGG:C00152", "KNApSAcK:C00001341", "MetaCyc:ASN", "PDBeChem:ASN", "PMID:12142634", "PMID:15907185", "PMID:16190636", "PMID:16368161", "PMID:16668324", "PMID:17497286", "PMID:21800258", "PMID:21854356", "PMID:22513289", "Reaxys:1723527", "Wikipedia:Asparagine", "YMDB:YMDB00226" ; oboInOwl:hasExactSynonym "L-Asparagine", "L-asparagine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2,4-diamino-4-oxobutanoic acid", "(2S)-2-amino-3-carbamoylpropanoic acid", "(S)-2-amino-3-carbamoylpropanoic acid", "(S)-Asparagine", "2-Aminosuccinamic acid", "ASPARAGINE", "Asn", "Aspartamic acid", "L-2-aminosuccinamic acid", "L-Asparagin", "L-aspartic acid beta-amide", "N", "alpha-aminosuccinamic acid" ; oboInOwl:id "CHEBI:17196" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-asparagine" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_22653, obo:CHEBI_22658, obo:CHEBI_83813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32650 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32651 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_28159 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_58048 ] . obo:CHEBI_17203 obo:IAO_0000115 "Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles." ; chebi:charge "0" ; chebi:formula "C5H9NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-N" ; chebi:mass "115.13050" ; chebi:monoisotopicmass "115.06333" ; chebi:smiles "OC(=O)[C@@H]1CCCN1" ; oboInOwl:hasAlternativeId "CHEBI:13154", "CHEBI:184637", "CHEBI:21373", "CHEBI:42067", "CHEBI:45040", "CHEBI:45100", "CHEBI:45159", "CHEBI:6286" ; oboInOwl:hasDbXref "Beilstein:80810", "CAS:147-85-3", "DrugBank:DB00172", "Drug_Central:4125", "Gmelin:50152", "HMDB:HMDB0000162", "KEGG:C00148", "KEGG:D00035", "KNApSAcK:C00001388", "MetaCyc:PRO", "PDBeChem:PRO", "PMID:11076505", "PMID:12770004", "PMID:14975886", "PMID:15576824", "PMID:15838615", "PMID:15894682", "PMID:15973048", "PMID:16033917", "PMID:16190672", "PMID:16501220", "PMID:16656443", "PMID:16657874", "PMID:16668324", "PMID:17127472", "PMID:17608428", "PMID:18551589", "PMID:18802692", "PMID:18973300", "PMID:19215998", "PMID:19580280", "PMID:19656302", "PMID:19688381", "PMID:19811425", "PMID:22139509", "PMID:22201772", "PMID:22451406", "PMID:22475019", "PMID:22482728", "PMID:22491679", "PMID:22770225", "Reaxys:80810", "Wikipedia:L-proline" ; oboInOwl:hasExactSynonym "L-Proline", "L-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-(S)-proline", "(-)-2-pyrrolidinecarboxylic acid", "(-)-proline", "(2S)-pyrrolidine-2-carboxylic acid", "(S)-2-carboxypyrrolidine", "(S)-2-pyrrolidinecarboxylic acid", "(S)-pyrrolidine-2-carboxylic acid", "2-Pyrrolidinecarboxylic acid", "L-(-)-proline", "L-Prolin", "L-alpha-pyrrolidinecarboxylic acid", "L-pyrrolidine-2-carboxylic acid", "P", "PROLINE", "prolina", "proline", "prolinum" ; oboInOwl:id "CHEBI:17203" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-proline" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_24318, obo:CHEBI_26271, obo:CHEBI_83813, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23366 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32862 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32864 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16313 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_60039 ] . obo:CHEBI_1722 obo:IAO_0000115 "Any 3beta-hydroxy-steroid that contains a double bond between positions 5 and 6." ; chebi:charge "0" ; chebi:formula "C19H29OR" ; chebi:mass "273.434" ; chebi:monoisotopicmass "273.22184" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CC=C4C2(CC[C@@H](C4)O)C" ; oboInOwl:hasAlternativeId "CHEBI:13608", "CHEBI:136845", "CHEBI:20245" ; oboInOwl:hasDbXref "KEGG:C03836", "MetaCyc:3b-hydroxy-D5-steroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3beta-hydroxy Delta(5)-steroids", "3beta-hydroxy-Delta(5)-steroids", "a 3beta-hydroxy-Delta(5)-steroid" ; oboInOwl:id "CHEBI:1722" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3beta-hydroxy-Delta(5)-steroid" ; rdfs:subClassOf obo:CHEBI_36836 . obo:CHEBI_17234 obo:IAO_0000115 "An aldohexose used as a source of energy and metabolic intermediate." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:14313", "CHEBI:24277", "CHEBI:33929", "CHEBI:5418" ; oboInOwl:hasDbXref "CAS:50-99-7", "KEGG:C00293", "Wikipedia:Glucose" ; oboInOwl:hasExactSynonym "Glucose", "gluco-hexose", "glucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DL-glucose", "Glc", "Glukose" ; oboInOwl:id "CHEBI:17234" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucose" ; rdfs:subClassOf obo:CHEBI_33917, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ] . obo:CHEBI_17258 obo:IAO_0000115 "The 7H-tautomer of purine." ; chebi:charge "0" ; chebi:formula "C5H4N4" ; chebi:inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" ; chebi:inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" ; chebi:mass "120.11222" ; chebi:monoisotopicmass "120.04360" ; chebi:smiles "c1ncc2[nH]cnc2n1" ; oboInOwl:hasAlternativeId "CHEBI:14968", "CHEBI:8639" ; oboInOwl:hasDbXref "Beilstein:3200", "Gmelin:601779", "HMDB:HMDB0001366", "KEGG:C15587", "Reaxys:3200" ; oboInOwl:hasExactSynonym "7H-purine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Purine", "Purine base" ; oboInOwl:id "CHEBI:17258" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "7H-purine" ; rdfs:subClassOf obo:CHEBI_35584, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35586 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35588 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35589 ] . obo:CHEBI_17272 obo:IAO_0000115 "The conjugate base of propionic acid; a key precursor in lipid biosynthesis." ; chebi:charge "-1" ; chebi:formula "C3H5O2" ; chebi:inchi "InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1" ; chebi:inchikey "XBDQKXXYIPTUBI-UHFFFAOYSA-M" ; chebi:mass "73.07060" ; chebi:monoisotopicmass "73.02950" ; chebi:smiles "CCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14903", "CHEBI:26290" ; oboInOwl:hasDbXref "Beilstein:3587503", "CAS:72-03-7", "Gmelin:1820", "KEGG:C00163", "PMID:17951291", "PMID:18375549", "PMID:2647392", "UM-BBD_compID:c0277" ; oboInOwl:hasExactSynonym "propanoate", "propionate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-CH2-COO(-)", "EtCO2 anion", "carboxylatoethane", "ethanecarboxylate", "ethylformate", "metacetonate", "methylacetate", "propanate", "propanoate", "propanoic acid, ion(1-)", "pseudoacetate" ; oboInOwl:id "CHEBI:17272" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "propionate" ; rdfs:subClassOf obo:CHEBI_78113, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30768 ] . obo:CHEBI_173084 obo:IAO_0000115 "Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." ; oboInOwl:hasDbXref "PMID:32015325", "PMID:32256352", "PMID:32413317", "PMID:33495651", "Wikipedia:Ferroptosis" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ferroptosis inhibitors" ; oboInOwl:id "CHEBI:173084" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ferroptosis inhibitor" ; rdfs:subClassOf obo:CHEBI_35222, obo:CHEBI_52206 . obo:CHEBI_173085 obo:IAO_0000115 "Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." ; oboInOwl:hasDbXref "PMID:31899616", "PMID:32015325", "PMID:33167414", "PMID:34012798", "Wikipedia:Ferroptosis" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ferroptosis inducers" ; oboInOwl:id "CHEBI:173085" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ferroptosis inducer" ; rdfs:subClassOf obo:CHEBI_52206 . obo:CHEBI_17325 obo:IAO_0000115 "A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid." ; chebi:charge "-2" ; chebi:formula "C6H8O5" ; chebi:inchi "InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)/p-2" ; chebi:inchikey "NPOAOTPXWNWTSH-UHFFFAOYSA-L" ; chebi:mass "160.12470" ; chebi:monoisotopicmass "160.03827" ; chebi:smiles "CC(O)(CC([O-])=O)CC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11813", "CHEBI:20042" ; oboInOwl:hasDbXref "KEGG:C03761", "MetaCyc:CPD-547" ; oboInOwl:hasExactSynonym "3-hydroxy-3-methylpentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy-3-methylglutarate" ; oboInOwl:id "CHEBI:17325" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy-3-methylglutarate(2-)" ; rdfs:subClassOf obo:CHEBI_133251, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30921 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30920 ] . obo:CHEBI_17347 obo:IAO_0000115 "An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.." ; chebi:charge "0" ; chebi:formula "C19H28O2" ; chebi:inchi "InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1" ; chebi:inchikey "MUMGGOZAMZWBJJ-DYKIIFRCSA-N" ; chebi:mass "288.42440" ; chebi:monoisotopicmass "288.20893" ; chebi:smiles "[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]" ; oboInOwl:hasAlternativeId "CHEBI:15214", "CHEBI:26883", "CHEBI:45798", "CHEBI:9461" ; oboInOwl:hasDbXref "Beilstein:1915399", "Beilstein:3653705", "CAS:58-22-0", "DrugBank:DB00624", "Drug_Central:2607", "Gmelin:538843", "HMDB:HMDB0000234", "KEGG:C00535", "KEGG:D00075", "KNApSAcK:C00003675", "LIPID_MAPS_instance:LMST02020002", "PDBeChem:TES", "PMID:10438974", "PMID:11786693", "PMID:18900503", "PMID:24498482", "Reaxys:1915399", "Wikipedia:Testosterone" ; oboInOwl:hasExactSynonym "17beta-hydroxyandrost-4-en-3-one", "TESTOSTERONE", "Testosterone", "testosterone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17beta-Hydroxy-4-androsten-3-one", "17beta-hydroxy-4-androsten-3-one", "4-androsten-17beta-ol-3-one", "Androderm", "Testosteron", "testosterona", "testosterone", "testosteronum" ; oboInOwl:id "CHEBI:17347" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "testosterone" ; rdfs:subClassOf obo:CHEBI_131621, obo:CHEBI_35343, obo:CHEBI_47909, obo:CHEBI_50402, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ] . obo:CHEBI_17359 obo:IAO_0000115 "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3)." ; chebi:charge "-2" ; chebi:formula "O3S" ; chebi:inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2" ; chebi:inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-L" ; chebi:mass "80.06420" ; chebi:monoisotopicmass "79.95791" ; chebi:smiles "[O-]S([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:15139", "CHEBI:45548" ; oboInOwl:hasDbXref "CAS:14265-45-3", "Gmelin:1449", "PDBeChem:SO3" ; oboInOwl:hasExactSynonym "sulfite", "trioxidosulfate(2-)", "trioxosulfate(2-)", "trioxosulfate(IV)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "SO3", "SO3(2-)", "SULFITE ION", "[SO3](2-)", "sulphite" ; oboInOwl:id "CHEBI:17359" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfite" ; rdfs:subClassOf obo:CHEBI_33482, obo:CHEBI_48154, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17137 ] . obo:CHEBI_17364 obo:IAO_0000115 "The D-enantiomer of aspartic acid." ; chebi:charge "0" ; chebi:formula "C4H7NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-UWTATZPHSA-N" ; chebi:mass "133.10270" ; chebi:monoisotopicmass "133.03751" ; chebi:smiles "N[C@H](CC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:20920", "CHEBI:4108" ; oboInOwl:hasDbXref "Beilstein:1723529", "CAS:1783-96-6", "DrugBank:DB02655", "Gmelin:602084", "HMDB:HMDB0006483", "KEGG:C00402", "MetaCyc:CPD-302", "PDBeChem:DAS", "PMID:11419736", "PMID:17118457", "PMID:17407322", "PMID:18318836", "PMID:19860889", "Reaxys:1723529" ; oboInOwl:hasExactSynonym "(2R)-2-aminobutanedioic acid", "D-Aspartic acid", "D-aspartic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-2-aminobutanedioic acid", "(R)-2-aminosuccinic acid", "D-Asparaginsaeure", "DAS", "aspartic acid D-form" ; oboInOwl:id "CHEBI:17364" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-aspartic acid" ; rdfs:subClassOf obo:CHEBI_16733, obo:CHEBI_22660, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29990 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17053 ] . obo:CHEBI_17368 obo:IAO_0000115 "A purine nucleobase that consists of purine bearing an oxo substituent at position 6." ; chebi:charge "0" ; chebi:formula "C5H4N4O" ; chebi:inchi "InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)" ; chebi:inchikey "FDGQSTZJBFJUBT-UHFFFAOYSA-N" ; chebi:mass "136.11162" ; chebi:monoisotopicmass "136.03851" ; chebi:smiles "O=c1[nH]cnc2nc[nH]c12" ; oboInOwl:hasAlternativeId "CHEBI:14431", "CHEBI:24762", "CHEBI:43237", "CHEBI:5841" ; oboInOwl:hasDbXref "Beilstein:5811", "CAS:68-94-0", "DrugBank:DB04076", "ECMDB:ECMDB00157", "Gmelin:464558", "HMDB:HMDB0000157", "KEGG:C00262", "KNApSAcK:C00001502", "MetaCyc:HYPOXANTHINE", "PDBeChem:HPA", "PMID:14253484", "PMID:1557408", "PMID:22735334", "PMID:23400363", "PMID:23670363", "PMID:8016081", "Reaxys:5811", "Wikipedia:Hypoxanthine", "YMDB:YMDB00555" ; oboInOwl:hasExactSynonym "1,7-dihydro-6H-purin-6-one", "HYPOXANTHINE", "Hypoxanthine", "hypoxanthine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "6(1H)-purinone", "6-oxopurine", "9H-purin-6(1H)-one", "Hyp", "Purine-6-ol", "purin-6(1H)-one" ; oboInOwl:id "CHEBI:17368" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hypoxanthine" ; rdfs:subClassOf obo:CHEBI_25810, obo:CHEBI_26386, obo:CHEBI_67142, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16708 ] . obo:CHEBI_17375 obo:IAO_0000115 "A 2-hydroxy monocarboxylic acid in which the carbon at position 2 has (S)-configuration." ; chebi:charge "0" ; chebi:formula "C2H3O3R" ; chebi:mass "75.044" ; chebi:monoisotopicmass "75.00822" ; chebi:smiles "C([C@@H](O)*)(=O)O" ; oboInOwl:hasAlternativeId "CHEBI:11031", "CHEBI:18737", "CHEBI:378", "CHEBI:381" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-hydroxy monocarboxylic acids", "(S)-2-Hydroxy acid", "(S)-2-Hydroxyalkanoic acid", "(S)-2-Hydroxycarboxylic acid", "(S)-2-Hydroxymonocarboxylic acid", "(S)-2-hydroxy acid" ; oboInOwl:id "CHEBI:17375" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(2S)-2-hydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_49302, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58123 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17893 ] . obo:CHEBI_17376 obo:IAO_0000115 "A sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond." ; chebi:charge "0" ; chebi:formula "C6H12N2O4S2" ; chebi:inchi "InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)" ; chebi:inchikey "LEVWYRKDKASIDU-UHFFFAOYSA-N" ; chebi:mass "240.30256" ; chebi:monoisotopicmass "240.02385" ; chebi:smiles "NC(CSSCC(N)C(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14062", "CHEBI:23513", "CHEBI:4052" ; oboInOwl:hasDbXref "Beilstein:1728091", "CAS:923-32-0", "Gmelin:83347", "KEGG:C01420", "PMID:18608550", "PMID:24327171", "PMID:24525029", "PMID:24525030", "Reaxys:1728091", "Wikipedia:Cystine" ; oboInOwl:hasExactSynonym "3,3'-disulfanediylbis(2-aminopropanoic acid)", "Cystine", "cystine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,3'-dithiobis(2-aminopropanoic acid)", "Cystin", "Dicysteine", "Zystin", "alpha-Diamino-beta-dithiolactic acid", "cistina" ; oboInOwl:id "CHEBI:17376" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cystine" ; rdfs:subClassOf obo:CHEBI_23509, obo:CHEBI_26834, obo:CHEBI_35489, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35492 ] . obo:CHEBI_17381 obo:IAO_0000115 "A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively." ; chebi:charge "0" ; chebi:formula "C10H14N2O4" ; chebi:inchi "InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)" ; chebi:inchikey "QSHWIQZFGQKFMA-UHFFFAOYSA-N" ; chebi:mass "226.22924" ; chebi:monoisotopicmass "226.09536" ; chebi:smiles "NCc1[nH]cc(CCC(O)=O)c1CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14867", "CHEBI:26212", "CHEBI:44832", "CHEBI:8335" ; oboInOwl:hasDbXref "Beilstein:220051", "CAS:487-90-1", "DrugBank:DB02272", "HMDB:HMDB0000245", "KEGG:C00931", "KNApSAcK:C00007339", "MetaCyc:PORPHOBILINOGEN", "PDBeChem:PBG", "PMID:21383008", "PMID:21627493", "PMID:22279024", "PMID:22740490", "PMID:22770225", "PMID:22974111", "Reaxys:220051", "Wikipedia:Porphobilinogen" ; oboInOwl:hasExactSynonym "3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid", "Porphobilinogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:17381" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "porphobilinogen" ; rdfs:subClassOf obo:CHEBI_26455, obo:CHEBI_35692, obo:CHEBI_64365, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58126 ] . obo:CHEBI_17418 obo:IAO_0000115 "A straight-chain saturated fatty acid containing five carbon atoms." ; chebi:charge "0" ; chebi:formula "C5H10O2" ; chebi:inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)" ; chebi:inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-N" ; chebi:mass "102.13170" ; chebi:monoisotopicmass "102.06808" ; chebi:smiles "CCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:113448", "CHEBI:27263", "CHEBI:27264", "CHEBI:43606", "CHEBI:44803", "CHEBI:7980" ; oboInOwl:hasDbXref "Beilstein:969454", "CAS:109-52-4", "DrugBank:DB02406", "Gmelin:26714", "HMDB:HMDB0000892", "KEGG:C00803", "KNApSAcK:C00001208", "LIPID_MAPS_instance:LMFA01010005", "PDBeChem:LEA", "PMID:20507156", "PPDB:3130", "Reaxys:969454", "Wikipedia:Valeric_acid" ; oboInOwl:hasExactSynonym "Valeric acid", "pentanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-butanecarboxylic acid", "CH3-[CH2]3-COOH", "PENTANOIC ACID", "Pentanoate", "Pentanoic acid", "Valerate", "Valerianic acid", "Valeriansaeure", "n-BuCOOH", "n-Pentanoate", "n-Valeric acid", "n-pentanoic acid", "n-valeric acid", "pentoic acid", "propylacetic acid", "valeric acid, normal" ; oboInOwl:id "CHEBI:17418" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "valeric acid" ; rdfs:subClassOf obo:CHEBI_26666, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_31011 ] . obo:CHEBI_17453 obo:IAO_0000115 "A C4-dicarboxylate resulting from the removal of a proton from both carboxylic acid groups of methylmalonic acid." ; chebi:charge "-2" ; chebi:formula "C4H4O4" ; chebi:inchi "InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/p-2" ; chebi:inchikey "ZIYVHBGGAOATLY-UHFFFAOYSA-L" ; chebi:mass "116.07216" ; chebi:monoisotopicmass "116.01206" ; chebi:smiles "CC(C([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14603", "CHEBI:25317" ; oboInOwl:hasDbXref "Beilstein:3904597", "Gmelin:142212", "KEGG:C02170", "MetaCyc:CPD-546", "Reaxys:3904597" ; oboInOwl:hasExactSynonym "methylpropanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methylmalonate", "methylmalonate dianion" ; oboInOwl:id "CHEBI:17453" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylmalonate(2-)" ; rdfs:subClassOf obo:CHEBI_61336, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15792 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30861 ] . obo:CHEBI_17478 obo:IAO_0000115 "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." ; chebi:charge "0" ; chebi:formula "CHOR" ; chebi:mass "29.01800" ; chebi:monoisotopicmass "29.00274" ; chebi:smiles "[H]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13432", "CHEBI:13753", "CHEBI:13805", "CHEBI:13806", "CHEBI:22291", "CHEBI:2554", "CHEBI:8750" ; oboInOwl:hasDbXref "KEGG:C00071" ; oboInOwl:hasExactSynonym "Aldehyde", "aldehyde", "aldehydes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aldehyd", "RC(=O)H", "RCHO", "aldehido", "aldehidos", "aldehydes", "aldehydum", "an aldehyde" ; oboInOwl:id "CHEBI:17478" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldehyde" ; rdfs:subClassOf obo:CHEBI_36586, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_42485 ] . obo:CHEBI_17485 obo:IAO_0000115 "An organic disulfide obtained by oxidative dimerisation of homocysteine." ; chebi:charge "0" ; chebi:formula "C8H16N2O4S2" ; chebi:inchi "InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)" ; chebi:inchikey "ZTVZLYBCZNMWCF-UHFFFAOYSA-N" ; chebi:mass "268.356" ; chebi:monoisotopicmass "268.05515" ; chebi:smiles "C(C(CCSSCCC(C(=O)O)N)N)(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14409", "CHEBI:24611", "CHEBI:5752" ; oboInOwl:hasDbXref "CAS:462-10-2", "HMDB:HMDB0000575", "KEGG:C01817", "PMID:11592966", "PMID:11896744", "Reaxys:1728581" ; oboInOwl:hasExactSynonym "4,4'-disulfanediylbis(2-aminobutanoic acid)", "Homocystine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4,4'-Dithiobis(2-aminobutyric acid)", "4,4'-dithiobis(2-aminobutyric acid)" ; oboInOwl:id "CHEBI:17485" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homocystine" ; rdfs:subClassOf obo:CHEBI_24612, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_58163 ] . obo:CHEBI_17522 obo:IAO_0000115 "A carbohydrate that is an acyclic polyol having the general formula HOCH2[CH(OH)]nCH2OH (formally derivable from an aldose by reduction of the carbonyl group)." ; chebi:charge "0" ; chebi:formula "(CH2O)nC2H6O2" ; oboInOwl:hasAlternativeId "CHEBI:13754", "CHEBI:22298", "CHEBI:2556" ; oboInOwl:hasDbXref "KEGG:C00717", "Wikipedia:Glycerin" ; oboInOwl:hasExactSynonym "Alditol", "alditol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Glycitol", "Sugar alcohol", "alditols" ; oboInOwl:id "CHEBI:17522" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alditol" ; rdfs:subClassOf obo:CHEBI_16646, obo:CHEBI_26191 . obo:CHEBI_17544 obo:IAO_0000115 "The carbon oxoanion resulting from the removal of a proton from carbonic acid." ; chebi:charge "-1" ; chebi:formula "CHO3" ; chebi:inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1" ; chebi:inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-M" ; chebi:mass "61.01684" ; chebi:monoisotopicmass "60.99312" ; chebi:smiles "OC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13363", "CHEBI:22863", "CHEBI:40961", "CHEBI:5589" ; oboInOwl:hasDbXref "Beilstein:3903504", "CAS:71-52-3", "Gmelin:49249", "HMDB:HMDB0000595", "KEGG:C00288", "MetaCyc:HCO3", "PDBeChem:BCT", "PMID:17215880", "PMID:17505962", "PMID:18439416", "PMID:28732801", "PMID:29150416", "PMID:29460248", "PMID:29466234", "PMID:4208463", "Wikipedia:Bicarbonate" ; oboInOwl:hasExactSynonym "Hydrogencarbonate", "hydrogen(trioxidocarbonate)(1-)", "hydrogencarbonate", "hydrogencarbonate(1-)", "hydrogentrioxocarbonate(1-)", "hydrogentrioxocarbonate(IV)", "hydroxidodioxidocarbonate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Acid carbonate", "BICARBONATE ION", "Bicarbonate", "HCO3(-)", "HCO3-", "[CO2(OH)](-)", "hydrogen carbonate" ; oboInOwl:id "CHEBI:17544" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogencarbonate" ; rdfs:subClassOf obo:CHEBI_35604, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_41609 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28976 ] . obo:CHEBI_17549 obo:IAO_0000115 "The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)" ; chebi:inchikey "ZGXJTSGNIOSYLO-UHFFFAOYSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "NCC(=O)CCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:2034", "CHEBI:20547" ; oboInOwl:hasDbXref "Beilstein:1759139", "CAS:106-60-5", "DrugBank:DB00855", "Drug_Central:166", "HMDB:HMDB0001149", "KEGG:C00430", "KEGG:D07567", "KNApSAcK:C00007378", "LINCS:LSM-5677", "PMID:11303952", "PMID:15756058", "PMID:15996585", "PMID:18982627", "PMID:19378778", "PMID:22378066", "PMID:22700502", "PMID:23242333", "PMID:23291627", "PMID:23299429", "PMID:23307195", "PMID:23339045", "PMID:23360321", "PMID:7890117", "Reaxys:1759139", "Wikipedia:Aminolevulinic_acid" ; oboInOwl:hasExactSynonym "5-amino-4-oxopentanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-ALA", "5-Amino-4-oxopentanoate", "5-Amino-4-oxovaleric acid", "5-Aminolevulinate", "aminolevulinic acid", "dALA", "delta-ALA", "delta-aminolevulinic acid" ; oboInOwl:id "CHEBI:17549" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-aminolevulinic acid" ; rdfs:subClassOf obo:CHEBI_35931, obo:CHEBI_35950, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35610 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_47868 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50177 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50266 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_45630 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_12109 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_132970 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_356416 ] . obo:CHEBI_17568 obo:IAO_0000115 "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." ; chebi:charge "0" ; chebi:formula "C4H4N2O2" ; chebi:inchi "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" ; chebi:inchikey "ISAKRJDGNUQOIC-UHFFFAOYSA-N" ; chebi:mass "112.08684" ; chebi:monoisotopicmass "112.02728" ; chebi:smiles "O=c1cc[nH]c(=O)[nH]1" ; oboInOwl:hasAlternativeId "CHEBI:15288", "CHEBI:27210", "CHEBI:46375", "CHEBI:9882" ; oboInOwl:hasDbXref "Beilstein:606623", "CAS:66-22-8", "DrugBank:DB03419", "Gmelin:2896", "HMDB:HMDB0000300", "KEGG:C00106", "KEGG:D00027", "KNApSAcK:C00001513", "MetaCyc:URACIL", "PDBeChem:URA", "PMID:11279060", "PMID:12855717", "PMID:15274295", "PMID:16834123", "PMID:17439666", "PMID:18533995", "PMID:18815805", "PMID:19175333", "PMID:22020693", "PMID:22074393", "PMID:22120518", "PMID:22171528", "PMID:22237209", "PMID:22299724", "PMID:22356544", "PMID:22447672", "PMID:22483865", "PMID:22567906", "PMID:22685418", "PMID:3654008", "Reaxys:606623", "Wikipedia:Uracil" ; oboInOwl:hasExactSynonym "URACIL", "Uracil", "pyrimidine-2,4(1H,3H)-dione", "uracil" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,4(1H,3H)-pyrimidinedione", "2,4-Dioxopyrimidine", "2,4-Pyrimidinedione", "U", "Ura", "Urazil" ; oboInOwl:id "CHEBI:17568" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "uracil" ; rdfs:subClassOf obo:CHEBI_26432, obo:CHEBI_38337, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50266 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50904 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_43254 ] . obo:CHEBI_17578 obo:IAO_0000115 "The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent." ; chebi:charge "0" ; chebi:formula "C7H8" ; chebi:inchi "InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3" ; chebi:inchikey "YXFVVABEGXRONW-UHFFFAOYSA-N" ; chebi:mass "92.13842" ; chebi:monoisotopicmass "92.06260" ; chebi:smiles "Cc1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:15248", "CHEBI:27022", "CHEBI:44023", "CHEBI:9624" ; oboInOwl:hasDbXref "Beilstein:635760", "CAS:108-88-3", "DrugBank:DB01900", "Gmelin:2456", "KEGG:C01455", "PDBeChem:MBN", "PMID:11182169", "PMID:11314682", "PMID:11846266", "PMID:11991009", "PMID:12062755", "PMID:12213539", "PMID:12237258", "PMID:12784113", "PMID:12876426", "PMID:14512097", "PMID:14559343", "PMID:14605898", "PMID:15015825", "PMID:15019953", "PMID:15119846", "PMID:15193425", "PMID:15542760", "PMID:15567510", "PMID:15695158", "PMID:15796064", "PMID:16316648", "PMID:16348226", "PMID:16601996", "PMID:17145141", "PMID:17175136", "PMID:17497535", "PMID:17725881", "PMID:18397809", "PMID:18832024", "PMID:19261054", "PMID:19384711", "PMID:19429395", "PMID:19635754", "PMID:19765629", "PMID:19825861", "PMID:19928203", "PMID:19969016", "PMID:20347282", "PMID:20837561", "PMID:21430649", "PMID:21655021", "PMID:21731073", "PMID:21802510", "PMID:21840036", "Reaxys:635760", "UM-BBD_compID:c0114", "Wikipedia:Toluene" ; oboInOwl:hasExactSynonym "TOLUENE", "Toluene", "toluene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Toluen", "Toluol", "methylbenzene", "phenylmethane" ; oboInOwl:id "CHEBI:17578" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "toluene" ; rdfs:subClassOf obo:CHEBI_134179, obo:CHEBI_27024, obo:CHEBI_38975, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48873 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50910 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_62803 ] . obo:CHEBI_17579 obo:IAO_0000115 "A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid." ; chebi:charge "0" ; chebi:formula "C40H56" ; chebi:inchi "InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+" ; chebi:inchikey "OENHQHLEOONYIE-JLTXGRSLSA-N" ; chebi:mass "536.87264" ; chebi:monoisotopicmass "536.43820" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C" ; oboInOwl:hasAlternativeId "CHEBI:10355", "CHEBI:12392", "CHEBI:22834", "CHEBI:40987" ; oboInOwl:hasDbXref "Beilstein:1917416", "CAS:7235-40-7", "COMe:MOL000093", "Drug_Central:345", "HMDB:HMDB0000561", "KEGG:C02094", "KEGG:D03101", "KNApSAcK:C00000919", "LIPID_MAPS_instance:LMPR01070000", "LIPID_MAPS_instance:LMPR01070001", "MetaCyc:CPD1F-129", "PDBeChem:BCR", "PMID:11171227", "PMID:11182771", "PMID:11332447", "PMID:11359610", "PMID:11382814", "PMID:11567548", "PMID:11677037", "PMID:11714348", "PMID:11962062", "PMID:12081834", "PMID:12891827", "PMID:14658721", "PMID:14764912", "PMID:14976384", "PMID:14997360", "PMID:15113067", "PMID:15333155", "PMID:15695449", "PMID:15789045", "PMID:15909543", "PMID:15949680", "PMID:15949683", "PMID:16036331", "PMID:16087476", "PMID:16338959", "PMID:16563447", "PMID:17004738", "PMID:17625873", "PMID:17708644", "PMID:17851775", "PMID:18429004", "PMID:18766464", "PMID:18767554", "PMID:18794175", "PMID:19480350", "PMID:19574250", "PMID:19669835", "PMID:19703237", "PMID:19852884", "PMID:19888275", "PMID:19896667", "PMID:19937581", "PMID:20074992", "PMID:20515074", "PMID:22079732", "PMID:22309480", "PMID:22428124", "PMID:22489215", "PMID:22534340", "PMID:22575730", "Reaxys:1917416", "Wikipedia:Beta_Carotene" ; oboInOwl:hasExactSynonym "BETA-CAROTENE", "beta,beta-carotene", "beta-Carotene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene)", "all-trans-beta-carotene", "beta-Karotin" ; oboInOwl:id "CHEBI:17579" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-carotene" ; rdfs:subClassOf obo:CHEBI_139120, obo:CHEBI_35163, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_173084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_26130 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_67200 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_17608 obo:IAO_0000115 "Any D-aldose having a chain of six carbon atoms in the molecule." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:12990", "CHEBI:21038" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-aldohexoses" ; oboInOwl:id "CHEBI:17608" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-aldohexose" ; rdfs:subClassOf obo:CHEBI_33917, obo:CHEBI_4194 . obo:CHEBI_17612 obo:IAO_0000115 "A dihydroxy monocarboxylic acid anion that is the conjugate base of (3,4-dihydroxyphenyl)acetic acid, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C8H7O4" ; chebi:inchi "InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1" ; chebi:inchikey "CFFZDZCDUFSOFZ-UHFFFAOYSA-M" ; chebi:mass "167.13878" ; chebi:monoisotopicmass "167.03498" ; chebi:smiles "Oc1ccc(CC([O-])=O)cc1O" ; oboInOwl:hasAlternativeId "CHEBI:11696", "CHEBI:11697", "CHEBI:19889" ; oboInOwl:hasDbXref "KEGG:C01161", "UM-BBD_compID:c0272" ; oboInOwl:hasExactSynonym "(3,4-dihydroxyphenyl)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,4-dihydroxyphenylacetate", "homoprotocatechuate" ; oboInOwl:id "CHEBI:17612" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(3,4-dihydroxyphenyl)acetate" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_18401 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_41941 ] . obo:CHEBI_17634 obo:IAO_0000115 "A glucose with D-configuration." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:12965", "CHEBI:20999" ; oboInOwl:hasDbXref "CAS:50-99-7" ; oboInOwl:hasExactSynonym "D-gluco-hexose", "D-glucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D(+)-glucose", "D-(+)-glucose", "Traubenzucker", "dextrose", "grape sugar" ; oboInOwl:id "CHEBI:17634" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glucose" ; rdfs:subClassOf obo:CHEBI_17234, obo:CHEBI_17608 . obo:CHEBI_176497 obo:IAO_0000115 "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." ; oboInOwl:hasDbXref "PMID:23372317", "PMID:28580190", "PMID:30885572", "PMID:33144142", "PMID:33973253", "PMID:34606237", "Wikipedia:Geroprotector" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-aging agent", "anti-aging agents", "anti-aging drug", "anti-aging drugs", "geroprotective agent", "geroprotective agents", "geroprotectors" ; oboInOwl:id "CHEBI:176497" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "geroprotector" ; rdfs:subClassOf obo:CHEBI_50267 . obo:CHEBI_17650 obo:IAO_0000115 "A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses." ; chebi:charge "0" ; chebi:formula "C21H30O5" ; chebi:inchi "InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1" ; chebi:inchikey "JYGXADMDTFJGBT-VWUMJDOOSA-N" ; chebi:mass "362.45990" ; chebi:monoisotopicmass "362.20932" ; chebi:smiles "[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO" ; oboInOwl:hasAlternativeId "CHEBI:14023", "CHEBI:24633", "CHEBI:3893", "CHEBI:58221" ; oboInOwl:hasDbXref "Beilstein:1354819", "CAS:50-23-7", "DrugBank:DB00741", "Drug_Central:1388", "KEGG:C00735", "KEGG:D00088", "LINCS:LSM-5980", "LIPID_MAPS_instance:LMST02030001", "PDBeChem:HCY", "PMID:10438974", "PMID:2268561", "Patent:US2602769", "Wikipedia:Hydrocortisone" ; oboInOwl:hasExactSynonym "11beta,17,21-trihydroxypregn-4-ene-3,20-dione", "Cortisol", "cortisol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione", "11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione", "11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione", "11beta-hydrocortisone", "17-hydroxycorticosterone", "4-pregnen-11beta,17alpha,21-triol-3,20-dione", "Hydrocortisone", "Kendall's compound F", "Reichstein's substance M", "hidrocortisona", "hydrocortisone", "hydrocortisonum" ; oboInOwl:id "CHEBI:17650" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cortisol" ; rdfs:subClassOf obo:CHEBI_138141, obo:CHEBI_139590, obo:CHEBI_139592, obo:CHEBI_24261, obo:CHEBI_35344, obo:CHEBI_35346, obo:CHEBI_36885, obo:CHEBI_47909, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35472 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_49167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50857 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_88188 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_8386 ] . obo:CHEBI_176842 obo:IAO_0000115 "Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin." ; oboInOwl:hasExactSynonym "vitamin B9" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "folate vitamer", "folate vitamers", "vitamin B-9", "vitamin B9 vitamer", "vitamin B9 vitamers", "vitamins B9" ; oboInOwl:id "CHEBI:176842" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin B9" ; rdfs:subClassOf obo:CHEBI_75769 . obo:CHEBI_176843 obo:IAO_0000115 "Any member of a group of cobalamin vitamers that exhibit biological activity against vitamin B12 deficiency. Vitamin B12 deficiency is associated with low red blood cell count and anemia. The vitamers are found in foods such as cereals, meat, fish, and poultry. The vitamers include adenosylcobalamin, hydroxocobalamin, cyanocobalamin, aquacobalamin, nitritocobalamin and methylcobabalamin (also includes their ionized, salt and phosphate derivatives)." ; oboInOwl:hasExactSynonym "vitamin B12" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vitamin B-12", "vitamin B12 vitamer", "vitamin B12 vitamers", "vitamins B12" ; oboInOwl:id "CHEBI:176843" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin B12" ; rdfs:subClassOf obo:CHEBI_75769 . obo:CHEBI_17754 obo:IAO_0000115 "A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups." ; chebi:charge "0" ; chebi:formula "C3H8O3" ; chebi:inchi "InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2" ; chebi:inchikey "PEDCQBHIVMGVHV-UHFFFAOYSA-N" ; chebi:mass "92.09382" ; chebi:monoisotopicmass "92.04734" ; chebi:smiles "OCC(O)CO" ; oboInOwl:hasAlternativeId "CHEBI:131422", "CHEBI:14334", "CHEBI:24351", "CHEBI:42998", "CHEBI:5448" ; oboInOwl:hasDbXref "Beilstein:635685", "CAS:56-81-5", "Chemspider:733", "DrugBank:DB04077", "Drug_Central:1316", "ECMDB:ECMDB00131", "FooDB:FDB000756", "Gmelin:26279", "HMDB:HMDB0000131", "KEGG:C00116", "KEGG:D00028", "KNApSAcK:C00001163", "LINCS:LSM-37180", "MetaCyc:GLYCEROL", "PDB:2AJS", "PDB:2D03", "PDBeChem:GOL", "PMID:11302662", "PMID:11958517", "PMID:11994365", "PMID:12672239", "PMID:12687625", "PMID:12689633", "PMID:12713573", "PMID:14559393", "PMID:14563847", "PMID:15026783", "PMID:15342117", "PMID:15786693", "PMID:15983192", "PMID:16244855", "PMID:16258193", "PMID:16319039", "PMID:16349488", "PMID:16475911", "PMID:16651733", "PMID:16664750", "PMID:16901854", "PMID:17336832", "PMID:17439666", "PMID:17979222", "PMID:19184438", "PMID:19231894", "PMID:19460032", "PMID:19548674", "PMID:19795216", "PMID:19956799", "PMID:22705534", "PMID:23562176", "PMID:23747440", "PMID:24643482", "PMID:24835191", "PMID:25108762", "PMID:558160", "PMID:6299616", "PMID:7031247", "PMID:7392035", "PPDB:1317", "Reaxys:635685", "UM-BBD_compID:c0066", "Wikipedia:Glycerol", "YMDB:YMDB00283" ; oboInOwl:hasExactSynonym "GLYCEROL", "Glycerol", "glycerol", "propane-1,2,3-triol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,2,3-Propanetriol", "1,2,3-Trihydroxypropane", "Glycerin", "Glyceritol", "Glyzerin", "Gro", "Oelsuess", "Propanetriol", "Trihydroxypropane", "glycerine", "glycerol", "glycerolum", "glycyl alcohol" ; oboInOwl:id "CHEBI:17754" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycerol" ; rdfs:subClassOf obo:CHEBI_17522, obo:CHEBI_27136, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_176497 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25728 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27780 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_46787 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ] . obo:CHEBI_17755 obo:IAO_0000115 "A modified amino acid generated by enzymic means from homocysteine and serine." ; chebi:charge "0" ; chebi:formula "C7H14N2O4S" ; chebi:inchi "InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)" ; chebi:inchikey "ILRYLPWNYFXEMH-UHFFFAOYSA-N" ; chebi:mass "222.26314" ; chebi:monoisotopicmass "222.06743" ; chebi:smiles "NC(CCSCC(N)C(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14059", "CHEBI:4048" ; oboInOwl:hasDbXref "CAS:535-34-2", "KEGG:C00542", "PMID:12907234", "PMID:15033753", "PMID:22212096", "PMID:22264337", "Reaxys:2416815" ; oboInOwl:hasExactSynonym "2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid", "Cystathionine", "S-(2-amino-2-carboxyethyl)homocysteine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DL-Cystathionine", "cystathione" ; oboInOwl:id "CHEBI:17755" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cystathionine" ; rdfs:subClassOf obo:CHEBI_16385, obo:CHEBI_23505, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ] . obo:CHEBI_17759 chebi:charge "0" ; chebi:formula "C27H44O" ; chebi:inchi "InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1" ; chebi:inchikey "UCTLRSWJYQTBFZ-DDPQNLDTSA-N" ; chebi:mass "384.63766" ; chebi:monoisotopicmass "384.33922" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C" ; oboInOwl:hasAlternativeId "CHEBI:13981", "CHEBI:23181", "CHEBI:3658" ; oboInOwl:hasDbXref "Beilstein:2224615", "CAS:434-16-2", "Gmelin:893079", "KEGG:C01164", "KNApSAcK:C00023747", "LIPID_MAPS_instance:LMST01010069" ; oboInOwl:hasExactSynonym "Cholesta-5,7-dien-3beta-ol", "cholesta-5,7-dien-3beta-ol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(3beta)-cholesta-5,7-dien-3-ol", "5,7-cholestadien-3-beta-ol", "5,7-cholestadien-3beta-ol", "7-Dehydrocholesterol", "7-dehydrocholesterol", "Provitamin D3" ; oboInOwl:id "CHEBI:17759" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholesta-5,7-dien-3beta-ol" ; rdfs:subClassOf obo:CHEBI_138131, obo:CHEBI_1722, obo:CHEBI_35348, obo:CHEBI_50401, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_17761 obo:IAO_0000115 "Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H." ; chebi:charge "0" ; chebi:formula "C4H6NO2R3" ; chebi:mass "100.09590" ; chebi:monoisotopicmass "100.03985" ; chebi:smiles "O[C@H]([*])[C@H](C[*])NC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:12487", "CHEBI:13954", "CHEBI:23074", "CHEBI:7242" ; oboInOwl:hasDbXref "KEGG:C00195", "LIPID_MAPS_class:LMSP02", "PMID:7542630", "Wikipedia:Ceramide" ; oboInOwl:hasExactSynonym "Ceramide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Cer", "N-acylated sphingoid", "a ceramide", "ceramides" ; oboInOwl:id "CHEBI:17761" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ceramide" ; rdfs:subClassOf obo:CHEBI_26739, obo:CHEBI_37622 . obo:CHEBI_17790 obo:IAO_0000115 "The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group." ; chebi:charge "0" ; chebi:formula "CH4O" ; chebi:inchi "InChI=1S/CH4O/c1-2/h2H,1H3" ; chebi:inchikey "OKKJLVBELUTLKV-UHFFFAOYSA-N" ; chebi:mass "32.04186" ; chebi:monoisotopicmass "32.02621" ; chebi:smiles "CO" ; oboInOwl:hasAlternativeId "CHEBI:14588", "CHEBI:25227", "CHEBI:44080", "CHEBI:44553", "CHEBI:6816" ; oboInOwl:hasDbXref "Beilstein:1098229", "CAS:67-56-1", "Gmelin:449", "HMDB:HMDB0001875", "KEGG:C00132", "KEGG:D02309", "MetaCyc:METOH", "PDBeChem:MOH", "PMID:11141607", "PMID:11430978", "PMID:11489599", "PMID:11680737", "PMID:11684179", "PMID:14012711", "PMID:14678513", "PMID:14760634", "PMID:15172721", "PMID:15906011", "PMID:16705261", "PMID:17451998", "PMID:17733096", "PMID:19064074", "PMID:19850112", "PMID:20314698", "Reaxys:1098229", "UM-BBD_compID:c0132", "Wikipedia:Methanol" ; oboInOwl:hasExactSynonym "METHANOL", "Methanol", "methanol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3OH", "MeOH", "Methyl alcohol", "Methylalkohol", "carbinol", "spirit of wood", "wood alcohol", "wood naphtha", "wood spirit" ; oboInOwl:id "CHEBI:17790" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methanol" ; rdfs:subClassOf obo:CHEBI_134179, obo:CHEBI_15734, obo:CHEBI_50584, obo:CHEBI_64708, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_131604 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33292 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48360 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_52090 ] . obo:CHEBI_177917 chebi:charge "0" ; chebi:formula "C18H23OR" ; chebi:mass "255.375" ; chebi:monoisotopicmass "255.17489" ; chebi:smiles "CC12CCC3C(CCC4=CC(O)=CC=C34)C1CCC2[*]" ; oboInOwl:hasAlternativeId "CHEBI:25968", "CHEBI:8074" ; oboInOwl:hasDbXref "KEGG:C02453", "MetaCyc:PHENOLIC-STEROID", "PMID:13752799", "PMID:4303459", "PMID:4622133", "PMID:4753431", "PMID:4798212", "PMID:4957953", "PMID:5790329", "PMID:6078089" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a phenolic steroid", "phenolic steroids" ; oboInOwl:id "CHEBI:177917" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenolic steroid" ; rdfs:subClassOf obo:CHEBI_33853, obo:CHEBI_36834 . obo:CHEBI_17792 obo:IAO_0000115 "A compound containing at least one carbon-halogen bond (where X is a halogen atom)." ; chebi:charge "0" ; chebi:formula "RX" ; chebi:smiles "**" ; oboInOwl:hasAlternativeId "CHEBI:13444", "CHEBI:36684", "CHEBI:8767" ; oboInOwl:hasDbXref "KEGG:C01322", "MetaCyc:Organohalogen-Compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "RX", "organic halide", "organic halides", "organohalogen compounds" ; oboInOwl:id "CHEBI:17792" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organohalogen compound" ; rdfs:subClassOf obo:CHEBI_33285, obo:CHEBI_37578 . obo:CHEBI_17822 obo:IAO_0000115 "An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group." ; chebi:charge "0" ; chebi:formula "C3H7NO3" ; chebi:inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)" ; chebi:inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-N" ; chebi:mass "105.09262" ; chebi:monoisotopicmass "105.04259" ; chebi:smiles "NC(CO)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:15081", "CHEBI:26648", "CHEBI:9116" ; oboInOwl:hasDbXref "Beilstein:1721402", "CAS:302-84-1", "Gmelin:26429", "KEGG:C00716", "KNApSAcK:C00001393", "Reaxys:1721402", "Wikipedia:Serine" ; oboInOwl:hasExactSynonym "Serine", "serine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-3-hydroxypropionic acid", "2-amino-3-hydroxypropanoic acid", "3-Hydroxyalanine", "Serin" ; oboInOwl:id "CHEBI:17822" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_24712 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32845 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32846 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35243 ] . obo:CHEBI_17823 obo:IAO_0000115 "A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol." ; chebi:charge "0" ; chebi:formula "C27H44O3" ; chebi:inchi "InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1" ; chebi:inchikey "GMRQFYUYWCNGIN-NKMMMXOESA-N" ; chebi:mass "416.63646" ; chebi:monoisotopicmass "416.32905" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O" ; oboInOwl:hasAlternativeId "CHEBI:13932", "CHEBI:19209", "CHEBI:3307", "CHEBI:46435" ; oboInOwl:hasDbXref "Beilstein:2227647", "CAS:32222-06-3", "DrugBank:DB00136", "Drug_Central:466", "KEGG:C01673", "KEGG:D00129", "LIPID_MAPS_instance:LMST03020258", "MetaCyc:CALCITRIOL", "PDBeChem:VDX", "PMID:10217585", "PMID:15928596", "PMID:19429426", "PMID:20599255", "PMID:22905919", "PMID:23103122", "PMID:23144765", "PMID:6687801", "Reaxys:2227647", "Wikipedia:Calcitriol" ; oboInOwl:hasExactSynonym "(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol", "Calcitriol", "calcitriol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol", "(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol", "(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol", "1,25-DHCC", "1-alpha-25-Dihydroxyvitamin D3", "1alpha,25(OH)2D3", "1alpha,25-dihydroxycholecalciferol", "1alpha,25-dihydroxyvitamin D3", "5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL", "Calcijex", "Decostriol", "Rocaltrol", "calcitriol", "calcitriolum" ; oboInOwl:id "CHEBI:17823" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calcitriol" ; rdfs:subClassOf obo:CHEBI_27136, obo:CHEBI_47042, obo:CHEBI_73558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35610 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_38807 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_38808 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50646 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50748 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50846 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_17855 obo:IAO_0000115 "Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids." ; chebi:charge "0" ; chebi:formula "C6H5O6R3" ; chebi:mass "173.10030" ; chebi:monoisotopicmass "173.00861" ; chebi:smiles "[*]C(=O)OCC(COC([*])=O)OC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:15255", "CHEBI:27085", "CHEBI:9664" ; oboInOwl:hasDbXref "KEGG:C00422", "LIPID_MAPS_class:LMGL0301", "PMID:2474544" ; oboInOwl:hasExactSynonym "Triglyceride", "triglycerides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Triacylglycerol", "Triglycerid", "Triglyzerid", "a triacylglycerol", "triacylglycerols", "triglycerides" ; oboInOwl:id "CHEBI:17855" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "triglyceride" ; rdfs:subClassOf obo:CHEBI_47778, obo:CHEBI_76579 . obo:CHEBI_17859 obo:IAO_0000115 "An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid." ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:inchi "InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)" ; chebi:inchikey "JFCQEDHGNNZCLN-UHFFFAOYSA-N" ; chebi:mass "132.11462" ; chebi:monoisotopicmass "132.04226" ; chebi:smiles "OC(=O)CCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24330", "CHEBI:43097", "CHEBI:5434" ; oboInOwl:hasDbXref "Beilstein:1209725", "CAS:110-94-1", "DrugBank:DB03553", "Gmelin:26809", "HMDB:HMDB0000661", "KEGG:C00489", "KNApSAcK:C00001184", "LIPID_MAPS_instance:LMFA01170046", "PDBeChem:GUA", "PMID:24297153", "PMID:24587932", "PMID:24900967", "Reaxys:1209725", "Wikipedia:Glutaric_acid" ; oboInOwl:hasExactSynonym "GLUTARIC ACID", "Glutaric acid", "pentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,3-Propanedicarboxylic acid", "1,5-pentanedioic acid", "Glutarsaeure", "Pentanedioic acid" ; oboInOwl:id "CHEBI:17859" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutaric acid" ; rdfs:subClassOf obo:CHEBI_189840, obo:CHEBI_28383, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_24329 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35907 ] . obo:CHEBI_17883 obo:IAO_0000115 "A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms." ; chebi:charge "0" ; chebi:formula "ClH", "HCl" ; chebi:inchi "InChI=1S/ClH/h1H" ; chebi:inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-N" ; chebi:mass "36.46064" ; chebi:monoisotopicmass "35.97668" ; chebi:smiles "Cl[H]" ; oboInOwl:hasAlternativeId "CHEBI:13364", "CHEBI:24635", "CHEBI:5590" ; oboInOwl:hasDbXref "CAS:7647-01-0", "Drug_Central:4568", "Gmelin:322", "HMDB:HMDB0002306", "KEGG:C01327", "KEGG:D02057", "MetaCyc:HCL", "PMID:15823700", "PMID:17492841", "PMID:22804993", "Reaxys:1098214", "Wikipedia:HCl", "Wikipedia:Hydrochloric_acid" ; oboInOwl:hasExactSynonym "Hydrogen chloride", "chlorane", "chloridohydrogen", "hydrogen chloride" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chlorwasserstoff", "HCl", "Hydrochloride", "Hydrogenchlorid", "Wasserstoffchlorid", "[HCl]", "chlorure d'hydrogene", "cloruro de hidrogeno", "hydrochloric acid" ; oboInOwl:id "CHEBI:17883" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogen chloride" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_18140, obo:CHEBI_23117, obo:CHEBI_37176, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17996 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_50315 ] . obo:CHEBI_17891 obo:IAO_0000115 "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." ; oboInOwl:hasAlternativeId "CHEBI:14202", "CHEBI:4697" ; oboInOwl:hasDbXref "KEGG:C01351" ; oboInOwl:hasExactSynonym "Donor" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Donator", "donneur" ; oboInOwl:id "CHEBI:17891" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "donor" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_17893 obo:IAO_0000115 "A 2-hydroxy monocarboxylic acid having (2R)-configuration." ; chebi:charge "0" ; chebi:formula "C2H3O3R" ; chebi:mass "75.04340" ; chebi:monoisotopicmass "75.00822" ; chebi:smiles "O[C@H]([*])C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10973", "CHEBI:18649", "CHEBI:309" ; oboInOwl:hasDbXref "KEGG:C02489", "KEGG:C15487" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-hydroxy monocarboxylic acids", "(2R)-Hydroxy-carboxylate", "(R)-2-Hydroxyacid", "(R)-2-Hydroxycarboxylic acid" ; oboInOwl:id "CHEBI:17893" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(2R)-2-hydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_49302, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58314 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17375 ] . obo:CHEBI_17924 obo:IAO_0000115 "The D-enantiomer of glucitol (also known as D-sorbitol)." ; chebi:charge "0" ; chebi:formula "C6H14O6" ; chebi:inchi "InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1" ; chebi:inchikey "FBPFZTCFMRRESA-JGWLITMVSA-N" ; chebi:mass "182.17176" ; chebi:monoisotopicmass "182.07904" ; chebi:smiles "OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:12954", "CHEBI:13020", "CHEBI:21091", "CHEBI:4246", "CHEBI:45559" ; oboInOwl:hasDbXref "Beilstein:1721899", "Beilstein:4656395", "CAS:50-70-4", "DrugBank:DB01638", "Drug_Central:2462", "Gmelin:83162", "HMDB:HMDB0000247", "KEGG:C00794", "KEGG:D00096", "KNApSAcK:C00001173", "PDBeChem:SOR", "PMID:16901854", "PMID:17336832", "PMID:17979222", "PMID:19443021", "PMID:19695255", "PMID:22735334", "PMID:22878210", "PMID:23683321", "PMID:24643482", "PMID:25108762", "PMID:25568069", "PMID:31537530", "PPDB:1320", "Reaxys:1721899", "Wikipedia:Sorbitol" ; oboInOwl:hasExactSynonym "D-Glucitol", "D-glucitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-sorbitol", "(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol", "D-(-)-sorbitol", "D-SORBITOL", "D-Sorbit", "D-Sorbitol", "D-sorbitol", "E 420", "E-420", "E420", "G-ol", "Glc-ol", "L-Gulitol" ; oboInOwl:id "CHEBI:17924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glucitol" ; rdfs:subClassOf obo:CHEBI_30911, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50503 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50505 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75325 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77969 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_28789 ] . obo:CHEBI_17933 obo:IAO_0000115 "A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3." ; chebi:charge "0" ; chebi:formula "C27H44O2" ; chebi:inchi "InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1" ; chebi:inchikey "JWUBBDSIWDLEOM-DTOXIADCSA-N" ; chebi:mass "400.63706" ; chebi:monoisotopicmass "400.33413" ; chebi:smiles "[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O" ; oboInOwl:hasAlternativeId "CHEBI:13931", "CHEBI:19815", "CHEBI:3304", "CHEBI:46387" ; oboInOwl:hasDbXref "Beilstein:4270041", "CAS:19356-17-3", "DrugBank:DB00146", "Drug_Central:464", "KEGG:C01561", "LIPID_MAPS_instance:LMST03020246", "PDBeChem:VDY", "PMID:16549446", "PMID:18689406", "PMID:22487892", "PMID:22536761", "PMID:23090338", "PMID:23566108", "PMID:9080330", "Reaxys:4270041", "Wikipedia:Calcifediol" ; oboInOwl:hasExactSynonym "(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol", "Calcidiol", "calcidiol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol", "(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol", "(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol", "25(OH)D3", "25-Hydroxyvitamin D3", "25-hydroxycholecalciferol", "25-hydroxyvitamin D3", "3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL", "Calcifediol", "Calcifediol anhydrous", "Rayaldee", "calcifediol", "calcifediolum" ; oboInOwl:id "CHEBI:17933" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calcidiol" ; rdfs:subClassOf obo:CHEBI_23824, obo:CHEBI_47042, obo:CHEBI_73558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50646 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_17968 obo:IAO_0000115 "A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C4H7O2" ; chebi:inchi "InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1" ; chebi:inchikey "FERIUCNNQQJTOY-UHFFFAOYSA-M" ; chebi:mass "87.09718" ; chebi:monoisotopicmass "87.04515" ; chebi:smiles "CCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13924", "CHEBI:22946" ; oboInOwl:hasDbXref "Beilstein:3601060", "CAS:461-55-2", "Gmelin:324289", "KEGG:C00246", "MetaCyc:BUTYRIC_ACID", "PMID:17190852", "PMID:7496326", "Reaxys:3601060", "UM-BBD_compID:c0035" ; oboInOwl:hasExactSynonym "butanoate", "butyrate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-butanoate", "1-butyrate", "1-propanecarboxylate", "CH3-[CH2]2-COO(-)", "butanate", "butanoate", "butanoic acid, ion(1-)", "n-butanoate", "n-butyrate", "propanecarboxylate", "propylformate" ; oboInOwl:id "CHEBI:17968" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "butyrate" ; rdfs:subClassOf obo:CHEBI_78115, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_61115 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30772 ] . obo:CHEBI_17996 obo:IAO_0000115 "A halide anion formed when chlorine picks up an electron to form an an anion." ; chebi:charge "-1" ; chebi:formula "Cl" ; chebi:inchi "InChI=1S/ClH/h1H/p-1" ; chebi:inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-M" ; chebi:mass "35.45270" ; chebi:monoisotopicmass "34.96940" ; chebi:smiles "[Cl-]" ; oboInOwl:hasAlternativeId "CHEBI:13291", "CHEBI:13970", "CHEBI:3616", "CHEBI:3731", "CHEBI:48804" ; oboInOwl:hasDbXref "Beilstein:3587171", "CAS:16887-00-6", "Gmelin:14910", "KEGG:C00115", "KEGG:C00698", "PDBeChem:CL", "UM-BBD_compID:c0884" ; oboInOwl:hasExactSynonym "Chloride", "chloride", "chloride(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CHLORIDE ION", "Chloride ion", "Chloride(1-)", "Chlorine anion", "Cl(-)", "Cl-" ; oboInOwl:id "CHEBI:17996" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chloride" ; rdfs:subClassOf obo:CHEBI_16042, obo:CHEBI_33432, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17883 ] . obo:CHEBI_18059 obo:IAO_0000115 "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." ; oboInOwl:hasAlternativeId "CHEBI:14517", "CHEBI:25054", "CHEBI:6486" ; oboInOwl:hasDbXref "KEGG:C01356" ; oboInOwl:hasExactSynonym "Lipid", "lipids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:18059" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lipid" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_18085 obo:IAO_0000115 "Any polysaccharide containing a substantial proportion of aminomonosaccharide residues." ; oboInOwl:hasAlternativeId "CHEBI:14361", "CHEBI:24398", "CHEBI:5495" ; oboInOwl:hasDbXref "KEGG:C02545", "Wikipedia:Glycosaminoglycan" ; oboInOwl:hasExactSynonym "Glycosaminoglycan", "glycosaminoglycan" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Glykosaminoglykan", "glicosaminoglicano", "glycosaminoglycane", "glycosaminoglycans" ; oboInOwl:id "CHEBI:18085" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycosaminoglycan" ; rdfs:subClassOf obo:CHEBI_22506 . obo:CHEBI_18089 obo:IAO_0000115 "An N-acylglycine in which the acyl group is specified as benzoyl." ; chebi:charge "0" ; chebi:formula "C9H9NO3" ; chebi:inchi "InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)" ; chebi:inchikey "QIAFMBKCNZACKA-UHFFFAOYSA-N" ; chebi:mass "179.17270" ; chebi:monoisotopicmass "179.05824" ; chebi:smiles "OC(=O)CNC(=O)c1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:12492", "CHEBI:14400", "CHEBI:24595", "CHEBI:5725" ; oboInOwl:hasDbXref "CAS:495-69-2", "HMDB:HMDB0000714", "KEGG:C01586", "KNApSAcK:C00030483", "MetaCyc:CPD-425", "PMID:14646363", "PMID:15879000", "PMID:16760132", "PMID:17190852", "PMID:19283696", "PMID:19891605", "PMID:20405919", "PMID:22770225", "PMID:7153346", "PMID:8734460", "PMID:9120876", "PMID:9609721", "Reaxys:1073987", "Wikipedia:Hippuric_acid" ; oboInOwl:hasExactSynonym "N-Benzoylglycine", "N-benzoylglycine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Benzamidoacetic acid", "Benzamidoessigsaeure", "Benzoylaminoacetic acid", "Benzoylaminoessigsaeure", "Hippurate", "Hippuric acid", "Hippursaeure", "Phenylcarbonylaminoacetic acid" ; oboInOwl:id "CHEBI:18089" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-benzoylglycine" ; rdfs:subClassOf obo:CHEBI_16180, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64584 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_85234 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_606565 ] . obo:CHEBI_18095 obo:IAO_0000115 "An optically active form of 4-hydroxyproline having L-trans-configuration." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1" ; chebi:inchikey "PMMYEEVYMWASQN-DMTCNVIQSA-N" ; chebi:mass "131.131" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "[C@H]1(C[C@@H](O)CN1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10714", "CHEBI:12864", "CHEBI:27060", "CHEBI:43172", "CHEBI:43210", "CHEBI:43227", "CHEBI:43318", "CHEBI:49360" ; oboInOwl:hasDbXref "CAS:51-35-4", "Drug_Central:4272", "HMDB:HMDB0000725", "KEGG:C01157", "KNApSAcK:C00001370", "MetaCyc:4-HYDROXY-L-PROLINE", "PDBeChem:HYP", "PMID:1117843", "PMID:1166829", "PMID:12148113", "PMID:14104082", "PMID:14995121", "PMID:15558350", "PMID:16096557", "PMID:16656634", "PMID:16662024", "PMID:16665943", "PMID:17021603", "PMID:19286848", "PMID:590925", "PMID:616023", "PMID:6616407", "PMID:6625779", "PMID:6783274", "PMID:7248905", "PMID:7283558", "PMID:7446210", "PMID:899882", "PMID:946341", "Reaxys:81441" ; oboInOwl:hasExactSynonym "(4R)-4-hydroxy-L-proline", "trans-4-Hydroxy-L-proline", "trans-4-hydroxy-L-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid", "(2S,4R)-trans-4-hydroxyproline", "Hydroxy-L-proline", "Hydroxyproline", "Hyp", "Hypro", "L-4-Hydroxyproline", "L-threo-4-hydroxyproline", "delta-hydroxyproline", "trans-Hydroxyproline", "trans-L-Hydroxyproline" ; oboInOwl:id "CHEBI:18095" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trans-4-hydroxy-L-proline" ; rdfs:subClassOf obo:CHEBI_20392, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_58375 ] . obo:CHEBI_18101 obo:IAO_0000115 "A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group." ; chebi:charge "0" ; chebi:formula "C8H8O3" ; chebi:inchi "InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)" ; chebi:inchikey "XQXPVVBIMDBYFF-UHFFFAOYSA-N" ; chebi:mass "152.14732" ; chebi:monoisotopicmass "152.04734" ; chebi:smiles "OC(=O)Cc1ccc(O)cc1" ; oboInOwl:hasAlternativeId "CHEBI:12014", "CHEBI:1874", "CHEBI:20419", "CHEBI:40091" ; oboInOwl:hasDbXref "CAS:156-38-7", "HMDB:HMDB0000020", "KEGG:C00642", "MetaCyc:4-HYDROXYPHENYLACETATE", "PDBeChem:4HP", "PMID:11339992", "PMID:21476434", "PMID:22296160", "PMID:24636068", "PMID:24831010", "PMID:7126379", "PMID:977696", "Reaxys:1448766", "UM-BBD_compID:c0271", "Wikipedia:4-hydroxyphenylacetic_acid" ; oboInOwl:hasExactSynonym "(4-hydroxyphenyl)acetic acid", "4-Hydroxyphenylacetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(p-hydroxyphenyl)acetic acid", "4-Hydroxyphenylacetate", "4-carboxymethylphenol", "4-hydroxybenzeneacetic acid", "p-hydroxyphenylacetic acid" ; oboInOwl:id "CHEBI:18101" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyphenylacetic acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_33853, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76946 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15366 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_48999 ] . obo:CHEBI_18133 obo:IAO_0000115 "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." ; oboInOwl:hasAlternativeId "CHEBI:14399", "CHEBI:24590", "CHEBI:5709" ; oboInOwl:hasDbXref "GlyGen:G70994MS", "GlyTouCan:G70994MS", "KEGG:C00738" ; oboInOwl:hasExactSynonym "Hexose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/", "hexoses" ; oboInOwl:id "CHEBI:18133" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexose" ; rdfs:subClassOf obo:CHEBI_35381 . obo:CHEBI_18139 obo:IAO_0000115 "A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group." ; chebi:charge "0" ; chebi:formula "C3H9N" ; chebi:inchi "InChI=1S/C3H9N/c1-4(2)3/h1-3H3" ; chebi:inchikey "GETQZCLCWQTVFV-UHFFFAOYSA-N" ; chebi:mass "59.11030" ; chebi:monoisotopicmass "59.07350" ; chebi:smiles "CN(C)C" ; oboInOwl:hasAlternativeId "CHEBI:15261", "CHEBI:27125", "CHEBI:27127", "CHEBI:9732" ; oboInOwl:hasDbXref "Beilstein:956566", "CAS:75-50-3", "Gmelin:1309", "HMDB:HMDB0000906", "KEGG:C00565", "KNApSAcK:C00001433", "MetaCyc:TRIMETHYLAMINE", "PDBeChem:KEN", "PMID:14047118", "PMID:15304308", "PMID:15752091", "PMID:17190852", "PMID:1801314", "PMID:24591617", "PMID:2501587", "PMID:5161463", "Reaxys:956566", "Wikipedia:Trimethylamine" ; oboInOwl:hasExactSynonym "N,N-dimethylmethanamine", "Trimethylamine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(CH3)3N", "N(CH3)3", "N,N,N-trimethylamine", "N,N-Dimethylmethanamine", "NMe3", "TMA", "Trimethylamin", "tridimethylaminomethane" ; oboInOwl:id "CHEBI:18139" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trimethylamine" ; rdfs:subClassOf obo:CHEBI_25274, obo:CHEBI_32876, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_58389 ] . obo:CHEBI_18140 chebi:charge "0" ; chebi:formula "HX" ; chebi:mass "1.008" ; chebi:monoisotopicmass "1.00783" ; chebi:smiles "[F,Cl,Br,I]" ; oboInOwl:hasAlternativeId "CHEBI:13368", "CHEBI:37140", "CHEBI:5599" ; oboInOwl:hasExactSynonym "hydrogen halide", "hydrogen halides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HX", "hydrogen halides" ; oboInOwl:id "CHEBI:18140" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogen halide" ; rdfs:subClassOf obo:CHEBI_33405, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_138103 ] . obo:CHEBI_18154 obo:IAO_0000115 "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." ; oboInOwl:hasAlternativeId "CHEBI:14864", "CHEBI:26205", "CHEBI:8322" ; oboInOwl:hasDbXref "KEGG:C00420" ; oboInOwl:hasExactSynonym "Polysaccharide", "polysaccharides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Glycan", "Glycane", "Glykan", "Glykane", "glycans", "polisacarido", "polisacaridos" ; oboInOwl:id "CHEBI:18154" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polysaccharide" ; rdfs:subClassOf obo:CHEBI_16646, obo:CHEBI_167559, obo:CHEBI_33694 . obo:CHEBI_18183 obo:IAO_0000115 "An optically active form of 5-oxoproline having L-configuration." ; chebi:charge "0" ; chebi:formula "C5H7NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1" ; chebi:inchikey "ODHCTXKNWHHXJC-VKHMYHEASA-N" ; chebi:mass "129.11400" ; chebi:monoisotopicmass "129.04259" ; chebi:smiles "OC(=O)[C@@H]1CCC(=O)N1" ; oboInOwl:hasAlternativeId "CHEBI:12153", "CHEBI:20619", "CHEBI:2113", "CHEBI:44704" ; oboInOwl:hasDbXref "Beilstein:5251861", "Beilstein:82132", "CAS:98-79-3", "DrugBank:DB03088", "Gmelin:1125330", "HMDB:HMDB0000267", "KEGG:C01879", "KNApSAcK:C00007403", "MetaCyc:5-OXOPROLINE", "PDBeChem:PCA", "PMID:17439666", "PMID:22560249", "PMID:22619187", "Reaxys:82132", "Wikipedia:Pyroglutamic_acid", "YMDB:YMDB00107" ; oboInOwl:hasExactSynonym "(2S)-5-oxopyrrolidine-2-carboxylic acid", "5-Oxo-L-proline", "5-oxo-L-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-2-pyrrolidone-5-carboxylic acid", "(S)-(-)-2-pyrrolidone-5-carboxylic acid", "(S)-pyroglutamic acid", "5-Pyrrolidone-2-carboxylic acid", "L-5-Pyrrolidone-2-carboxylic acid", "L-Pyroglutamic acid", "PYROGLUTAMIC ACID", "Pyroglutamate", "Pyroglutamic acid", "pidolic acid" ; oboInOwl:id "CHEBI:18183" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxo-L-proline" ; rdfs:subClassOf obo:CHEBI_16010, obo:CHEBI_83822, obo:CHEBI_84186, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58402 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_16924 ] . obo:CHEBI_18186 obo:IAO_0000115 "An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring." ; chebi:charge "0" ; chebi:formula "C9H11NO3" ; chebi:inchi "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)" ; chebi:inchikey "OUYCCCASQSFEME-UHFFFAOYSA-N" ; chebi:mass "181.18858" ; chebi:monoisotopicmass "181.07389" ; chebi:smiles "NC(Cc1ccc(O)cc1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:15277", "CHEBI:27176", "CHEBI:9800" ; oboInOwl:hasDbXref "Beilstein:515881", "CAS:55520-40-6", "CAS:556-03-6", "Gmelin:27744", "KEGG:C01536", "KNApSAcK:C00001397", "PMID:17190852", "Reaxys:515881" ; oboInOwl:hasExactSynonym "Tyrosine", "tyrosine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-3-(p-hydroxyphenyl)propionic acid", "2-amino-3-(4-hydroxyphenyl)propanoic acid", "3-(p-Hydroxyphenyl)alanine", "Tyr", "Tyrosin", "Y", "tirosina" ; oboInOwl:id "CHEBI:18186" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tyrosine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_33856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50336 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30768 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32784 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32786 ] . obo:CHEBI_18211 obo:IAO_0000115 "The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position." ; chebi:charge "0" ; chebi:formula "C6H13N3O3" ; chebi:inchi "InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)" ; chebi:inchikey "RHGKLRLOHDJJDR-UHFFFAOYSA-N" ; chebi:mass "175.18584" ; chebi:monoisotopicmass "175.09569" ; chebi:smiles "NC(CCCNC(N)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:14002", "CHEBI:3730" ; oboInOwl:hasDbXref "Beilstein:1725417", "Beilstein:2328251", "CAS:627-77-0", "PMID:11094453", "PMID:11113071", "PMID:11696417", "PMID:1378088", "PMID:16082501", "PMID:16708633", "PMID:17005970", "PMID:17513438", "PMID:17558653", "PMID:17693747", "PMID:18437289", "PMID:18440672", "PMID:18989563", "PMID:19144577", "PMID:21129371", "PMID:21482070", "Reaxys:1725417", "Wikipedia:Citrulline" ; oboInOwl:hasExactSynonym "2-amino-5-(carbamoylamino)pentanoic acid", "Citrulline", "N(5)-carbamoylornithine", "citrulline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-5-uredovaleric acid", "Cit", "Citrullin", "DL-2-amino-5-ureidovaleric acid", "N(5)-(aminocarbonyl)-DL-ornithine", "N(5)-(aminocarbonyl)ornithine", "N(5)-carbamoyl-DL-ornithine", "citrulina", "dl-citrulline" ; oboInOwl:id "CHEBI:18211" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrulline" ; rdfs:subClassOf obo:CHEBI_23324, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59174 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66922 ] . obo:CHEBI_18237 obo:IAO_0000115 "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2." ; chebi:charge "0" ; chebi:formula "C5H9NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)" ; chebi:inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-N" ; chebi:mass "147.12930" ; chebi:monoisotopicmass "147.05316" ; chebi:smiles "NC(CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24314", "CHEBI:5431" ; oboInOwl:hasDbXref "Beilstein:1723799", "CAS:617-65-2", "Gmelin:101971", "KEGG:C00302", "KEGG:D04341", "KNApSAcK:C00001358", "KNApSAcK:C00019577", "PMID:15739367", "PMID:17190852", "PMID:24616376", "PMID:24984001", "Reaxys:1723799", "Wikipedia:Glutamic_acid" ; oboInOwl:hasExactSynonym "2-aminopentanedioic acid", "Glutamic acid", "glutamic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Aminoglutaric acid", "DL-Glutamic acid", "DL-Glutaminic acid", "E", "Glu", "Glutamate", "Glutaminic acid", "Glutaminsaeure" ; oboInOwl:id "CHEBI:18237" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamic acid" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50329 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_14321 ] . obo:CHEBI_18240 obo:IAO_0000115 "The L-stereoisomer of 4-hydroxyproline." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3?,4-/m0/s1" ; chebi:inchikey "PMMYEEVYMWASQN-BKLSDQPFSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "OC1CN[C@@H](C1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:11999", "CHEBI:1852" ; oboInOwl:hasDbXref "CAS:51-35-4", "HMDB:HMDB0006055", "KEGG:C01015", "KNApSAcK:C00001370", "Reaxys:81441", "Wikipedia:4-hydroxy-L-proline" ; oboInOwl:hasExactSynonym "4-Hydroxy-L-proline", "4-hydroxy-L-proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-4-hydroxypyrrolidine-2-carboxylic acid", "L-Hydroxyproline", "cis-4-Hydroxy-L-Proline", "hydroxy-L-proline" ; oboInOwl:id "CHEBI:18240" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxy-L-proline" ; rdfs:subClassOf obo:CHEBI_20392, obo:CHEBI_83822, obo:CHEBI_84186, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62981 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_144637 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_58419 ] . obo:CHEBI_18243 obo:IAO_0000115 "Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group." ; chebi:charge "0" ; chebi:formula "C8H11NO2" ; chebi:inchi "InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2" ; chebi:inchikey "VYFYYTLLBUKUHU-UHFFFAOYSA-N" ; chebi:mass "153.17840" ; chebi:monoisotopicmass "153.07898" ; chebi:smiles "NCCc1ccc(O)c(O)c1" ; oboInOwl:hasAlternativeId "CHEBI:11695", "CHEBI:11930", "CHEBI:14203", "CHEBI:1764", "CHEBI:23886", "CHEBI:43686" ; oboInOwl:hasDbXref "CAS:51-61-6", "DrugBank:DB00988", "Drug_Central:947", "HMDB:HMDB0000073", "KEGG:C03758", "KEGG:D07870", "KNApSAcK:C00001408", "LINCS:LSM-4630", "MetaCyc:DOPAMINE", "PMID:10629745", "PMID:11149432", "PMID:9422813", "Reaxys:1072822", "Wikipedia:Dopamine" ; oboInOwl:hasExactSynonym "4-(2-aminoethyl)benzene-1,2-diol", "Dopamine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-(3,4-Dihydroxyphenyl)ethylamine", "2-(3,4-dihydroxyphenyl)ethylamine", "3,4-Dihydroxyphenethylamine", "3-Hydroxytyramine", "4-(2-Aminoethyl)-1,2-benzenediol", "4-(2-Aminoethyl)benzene-1,2-diol", "4-(2-aminoethyl)-1,2-benzenediol", "4-(2-aminoethyl)catechol", "4-(2-aminoethyl)pyrocatechol", "Deoxyepinephrine", "Hydroxytyramin", "dopamina", "dopamine", "dopaminum" ; oboInOwl:id "CHEBI:18243" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dopamine" ; rdfs:subClassOf obo:CHEBI_33567, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35522 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35524 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_38147 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48560 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_59905 ] . obo:CHEBI_18248 obo:IAO_0000115 "An iron group element atom that has atomic number 26." ; chebi:charge "0" ; chebi:formula "Fe" ; chebi:inchi "InChI=1S/Fe" ; chebi:inchikey "XEEYBQQBJWHFJM-UHFFFAOYSA-N" ; chebi:mass "55.84500" ; chebi:monoisotopicmass "55.93494" ; chebi:smiles "[Fe]" ; oboInOwl:hasAlternativeId "CHEBI:13322", "CHEBI:24872", "CHEBI:5974" ; oboInOwl:hasDbXref "CAS:7439-89-6", "DrugBank:DB01592", "HMDB:HMDB0015531", "KEGG:C00023", "Reaxys:4122945", "WebElements:Fe" ; oboInOwl:hasExactSynonym "iron" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "26Fe", "Eisen", "Fe", "Iron", "fer", "ferrum", "hierro", "iron" ; oboInOwl:id "CHEBI:18248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron atom" ; rdfs:subClassOf obo:CHEBI_33356, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ] . obo:CHEBI_18257 obo:IAO_0000115 "An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5." ; chebi:charge "0" ; chebi:formula "C5H12N2O2" ; chebi:inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)" ; chebi:inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-N" ; chebi:mass "132.16106" ; chebi:monoisotopicmass "132.08988" ; chebi:smiles "NCCCC(N)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:7784" ; oboInOwl:hasDbXref "Beilstein:1722296", "CAS:616-07-9", "Gmelin:847696", "KEGG:C01602", "KNApSAcK:C00001384", "PMID:15449570", "PMID:17190852", "PMID:22264337", "Reaxys:1722296" ; oboInOwl:hasExactSynonym "2,5-diaminopentanoic acid", "Ornithine", "ornithine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,5-Diaminopentanoic acid", "2,5-Diaminovaleric acid", "DL-Ornithine", "Orn" ; oboInOwl:id "CHEBI:18257" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ornithine" ; rdfs:subClassOf obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32964 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_46912 ] . obo:CHEBI_18258 obo:IAO_0000115 "An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism." ; chebi:charge "0" ; chebi:formula "C15H12I3NO4" ; chebi:inchi "InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1" ; chebi:inchikey "AUYYCJSJGJYCDS-LBPRGKRZSA-N" ; chebi:mass "650.97350" ; chebi:monoisotopicmass "650.79004" ; chebi:smiles "N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:11701", "CHEBI:11702", "CHEBI:13059", "CHEBI:19894", "CHEBI:45840", "CHEBI:9722" ; oboInOwl:hasDbXref "Beilstein:2710227", "CAS:6893-02-3", "DrugBank:DB00279", "Drug_Central:1585", "HMDB:HMDB0000265", "KEGG:C02465", "KEGG:D08128", "LINCS:LSM-3991", "MetaCyc:CPD-10813", "PDBeChem:T3", "PMID:11738632", "PMID:15206581", "PMID:19339791", "Reaxys:2710227", "Wikipedia:Triiodothyronine" ; oboInOwl:hasExactSynonym "3,3',5-triiodo-L-thyronine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,5,3'-Triiodo-L-thyronine", "3,5,3'-Triiodothyronine", "3,5,3'TRIIODOTHYRONINE", "4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine", "L-3,5,3'-Triiodothyronine", "L-T3", "Liothyronine", "O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine", "T3", "Tertroxin", "Tresitope", "Triiodothyronine", "liothyronine", "liothyroninum", "liotironina" ; oboInOwl:id "CHEBI:18258" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3,3',5-triiodo-L-thyronine" ; rdfs:subClassOf obo:CHEBI_24863, obo:CHEBI_24864, obo:CHEBI_53291, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_60311 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_60308 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_533015 ] . obo:CHEBI_18259 obo:IAO_0000115 "A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component." ; chebi:charge "0" ; chebi:formula "C45H79N2O23R" ; chebi:mass "1016.10840" ; chebi:monoisotopicmass "1015.50736" ; chebi:smiles "CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)NC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:12452", "CHEBI:12557", "CHEBI:21508", "CHEBI:21513", "CHEBI:24252", "CHEBI:5388" ; oboInOwl:hasDbXref "CAS:11034-93-8", "KEGG:C03272", "KEGG:G00094", "PMID:1528196", "PMID:15495792", "PMID:15661151", "PMID:1601891", "PMID:1724444", "PMID:21252262", "PMID:21376640", "PMID:2448252", "PMID:2456994", "PMID:3220436", "PMID:4026313", "PMID:7287743", "PMID:7690848", "PMID:7691279", "PMID:8161226" ; oboInOwl:hasExactSynonym "N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(Gal)2 (GalNAc)1 (Glc)1 (Cer)1", "CTH/Gb4", "GalNAc-1->3-Gal-1->4-Gal-1->4-Glc-Cer", "GalNAcbeta1-3-Galalpha1-4Galbeta1-4Glcbeta1-1Cer", "Gb4 Globoside", "Gb4 Globotetraosyl ceramide", "Gb4Cer", "GbOse4Cer", "Gbose4Cer", "Globoside GL-4", "Globoside I", "Globotetraosyl ceramide", "N-Acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide", "N-Acetyl-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide", "N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosylceramides", "Slt-iiv receptor", "VT2vp1 Receptor", "beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer", "beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer", "globoside Gb4Cer (d18:1(4E))" ; oboInOwl:id "CHEBI:18259" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide" ; rdfs:subClassOf obo:CHEBI_23075, obo:CHEBI_61360, obo:CHEBI_88167, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_142533 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_142567 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59132 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_18282 obo:IAO_0000115 "That part of DNA or RNA that may be involved in pairing." ; oboInOwl:hasAlternativeId "CHEBI:13873", "CHEBI:25598", "CHEBI:2995" ; oboInOwl:hasDbXref "KEGG:C00701", "Wikipedia:Nucleobase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Base", "nucleobases" ; oboInOwl:id "CHEBI:18282" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nucleobase" ; rdfs:subClassOf obo:CHEBI_38101 . obo:CHEBI_18287 obo:IAO_0000115 "Any form of fucose having L configuration." ; chebi:charge "0" ; chebi:formula "C6H12O5" ; chebi:mass "164.15648" ; chebi:monoisotopicmass "164.06847" ; oboInOwl:hasAlternativeId "CHEBI:13102", "CHEBI:21293" ; oboInOwl:hasDbXref "CAS:2438-80-4", "PMID:20877283" ; oboInOwl:hasExactSynonym "6-deoxy-L-galactose", "L-fucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-L-fucose", "(-)-fucose", "L-(-)-fucose", "L-Fuc", "L-galactomethylose" ; oboInOwl:id "CHEBI:18287" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-fucose" ; rdfs:subClassOf obo:CHEBI_33984, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_18310 obo:IAO_0000115 "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." ; chebi:charge "0" ; chebi:formula "CH3R" ; chebi:mass "15.035" ; chebi:monoisotopicmass "15.02348" ; chebi:smiles "C[*]" ; oboInOwl:hasAlternativeId "CHEBI:13435", "CHEBI:22317", "CHEBI:2576" ; oboInOwl:hasDbXref "KEGG:C01371" ; oboInOwl:hasExactSynonym "Alkane", "alkane", "alkanes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alkan", "RH", "alcane", "alcanes", "alcano", "alcanos", "an alkane" ; oboInOwl:id "CHEBI:18310" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkane" ; rdfs:subClassOf obo:CHEBI_24632, obo:CHEBI_33653 . obo:CHEBI_18361 chebi:charge "-4" ; chebi:formula "O7P2" ; chebi:inchi "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-4" ; chebi:inchikey "XPPKVPWEQAFLFU-UHFFFAOYSA-J" ; chebi:mass "173.94332" ; chebi:monoisotopicmass "173.91412" ; chebi:smiles "[O-]P([O-])(=O)OP([O-])([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13420", "CHEBI:42009" ; oboInOwl:hasDbXref "CAS:14000-31-8", "Gmelin:26938", "KEGG:C00013", "PDBeChem:DPO" ; oboInOwl:hasExactSynonym "diphosphate", "mu-oxido-bis(trioxidophosphate)(4-)", "mu-oxo-hexaoxodiphosphate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DIPHOSPHATE", "Diphosphat", "Diphosphate", "P2O7(4-)", "PPi", "Pyrophosphat", "Pyrophosphate", "[O3POPO3](4-)", "pyrophosphate ion" ; oboInOwl:id "CHEBI:18361" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphate(4-)" ; rdfs:subClassOf obo:CHEBI_35782, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33019 ] . obo:CHEBI_18367 obo:IAO_0000115 "A phosphate ion that is the conjugate base of hydrogenphosphate." ; chebi:charge "-3" ; chebi:formula "O4P" ; chebi:inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3" ; chebi:inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-K" ; chebi:mass "94.97136" ; chebi:monoisotopicmass "94.95507" ; chebi:smiles "[O-]P([O-])([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14791", "CHEBI:45024", "CHEBI:7793" ; oboInOwl:hasDbXref "Beilstein:3903772", "CAS:14265-44-2", "Gmelin:1997", "KEGG:C00009", "PDBeChem:PO4", "Reaxys:3903772" ; oboInOwl:hasExactSynonym "phosphate", "tetraoxidophosphate(3-)", "tetraoxophosphate(3-)", "tetraoxophosphate(V)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Orthophosphate", "PHOSPHATE ION", "PO4(3-)", "Phosphate", "[PO4](3-)" ; oboInOwl:id "CHEBI:18367" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphate(3-)" ; rdfs:subClassOf obo:CHEBI_35780, obo:CHEBI_79387, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_43474 ] . obo:CHEBI_18376 obo:IAO_0000115 "Any of a group of glycosaminoglycans with repeating units consisting of variously sulfated beta1->4-linked L-iduronyl-(alpha1->3)-N-acetyl-D-galactosamine units." ; chebi:formula "H2O.(C14H20NO13S)n" ; oboInOwl:hasAlternativeId "CHEBI:14127", "CHEBI:23644", "CHEBI:4440" ; oboInOwl:hasDbXref "Beilstein:8390617", "CAS:24967-94-0", "KEGG:C00426" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chondroitin sulfate B", "Dermatan L-iduronate", "beta-Heparin" ; oboInOwl:id "CHEBI:18376" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dermatan sulfate" ; rdfs:subClassOf obo:CHEBI_35722, obo:CHEBI_37395, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50248 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50249 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_4439 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58465 ] . obo:CHEBI_18401 obo:IAO_0000115 "A monocarboxylic acid anion that is the conjugate base of phenylacetic acid." ; chebi:charge "-1" ; chebi:formula "C8H7O2" ; chebi:inchi "InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1" ; chebi:inchikey "WLJVXDMOQOGPHL-UHFFFAOYSA-M" ; chebi:mass "135.13998" ; chebi:monoisotopicmass "135.04515" ; chebi:smiles "[O-]C(=O)Cc1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:14779", "CHEBI:25975" ; oboInOwl:hasDbXref "Beilstein:3539899", "Gmelin:327522", "MetaCyc:PHENYLACETATE", "Reaxys:3539899", "UM-BBD_compID:c0211" ; oboInOwl:hasExactSynonym "phenylacetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-phenylacetate", "2-phenylethanoate", "phenylacetate anion", "phenylacetate(1-)", "phenylacetic acid anion" ; oboInOwl:id "CHEBI:18401" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylacetate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30089 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30745 ] . obo:CHEBI_18408 obo:IAO_0000115 "A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12." ; chebi:charge "0" ; chebi:formula "C72H100CoN18O17P" ; chebi:inchi "InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1" ; chebi:inchikey "ZIHHMGTYZOSFRC-OUCXYWSSSA-L" ; chebi:mass "1579.58180" ; chebi:monoisotopicmass "1578.65834" ; chebi:smiles "[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]4[C@@H](CO)O[C@@H]([C@@H]4O)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C[C@H]7O[C@H]([C@H](O)[C@@H]7O)n7cnc8c(N)ncnc78)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O" ; oboInOwl:hasAlternativeId "CHEBI:13739", "CHEBI:23340", "CHEBI:3797" ; oboInOwl:hasDbXref "Beilstein:4122932", "CAS:13870-90-1", "DrugBank:DB11191", "Gmelin:439994", "HMDB:HMDB0002086", "KEGG:C00194", "MetaCyc:ADENOSYLCOBALAMIN", "PDBeChem:B1Z", "PMID:11792214", "PMID:12093296", "PMID:17011224", "Reaxys:4122932", "Wikipedia:Cobamamide" ; oboInOwl:hasExactSynonym "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide", "Cobamamide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(5,6-Dimethylbenzimidazolyl)cobamide coenzyme", "(5,6-dimethylbenzimidazolyl)cobamide coenzyme", "5'-Deoxy-5'-adenosyl vitamin B12", "5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide", "5'-Deoxy-5'-adenosylcobalamin", "5'-deoxyadenosyl vitamin B12", "5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide", "5'-deoxyadenosylcobalamin", "5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide", "5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide", "Adenosylcob(III)alamin", "Adenosylcobalamin", "AdoCbl", "Calomide", "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide", "Cobalamin coenzyme", "Coenzyme B12", "DBC coenzyme", "DMBC coenzyme", "Deoxyadenosylcobalamin", "Dibencozide", "Funacomide", "Vitamin B12 coenzyme", "adenosylcob(III)alamin", "adenosylcobalamin", "alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme", "cobamamid", "cobamamida", "cobamamide", "cobamamidum", "cobamide coenzyme", "coenzyme B-12" ; oboInOwl:id "CHEBI:18408" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobamamide" ; rdfs:subClassOf obo:CHEBI_23334, obo:CHEBI_33913, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23354 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_26348 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_189840 obo:IAO_0000115 "Any fatty acid containing two carboxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:189840" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "dicarboxylic fatty acid" ; rdfs:subClassOf obo:CHEBI_35692, obo:CHEBI_61697, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_189846 ] . obo:CHEBI_189846 obo:IAO_0000115 "Any fatty acid that contains 2 carboxylic groups. Major microspecies at pH 7.3" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a dicarboxylic fatty acid" ; oboInOwl:id "CHEBI:189846" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "dicarboxylic fatty acid dianion" ; rdfs:subClassOf obo:CHEBI_28965, obo:CHEBI_61697, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_189840 ] . obo:CHEBI_191220 obo:IAO_0000115 "The dicarboxylate anion of (S)-methylsuccinic acid; major species at pH 7.3." ; chebi:charge "-2" ; chebi:formula "C5H6O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-3(5(8)9)2-4(6)7/h3H,2H2,1H3,(H,6,7)(H,8,9)/p-2/t3-/m0/s1" ; chebi:inchikey "WXUAQHNMJWJLTG-VKHMYHEASA-L" ; chebi:mass "130.100" ; chebi:monoisotopicmass "130.02771" ; chebi:smiles "[O-]C(=O)[C@H](CC([O-])=O)C" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-methylsuccinate" ; oboInOwl:id "CHEBI:191220" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "(2S)-methylsuccinate(2-)" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_91316 ] . obo:CHEBI_19168 obo:IAO_0000115 "Any oxo steroid carrying the oxo group at position 17." ; chebi:charge "0" ; chebi:formula "C18H27OR" ; chebi:mass "259.407" ; chebi:monoisotopicmass "259.20619" ; chebi:smiles "CC12CCC3C(CCC4CCCCC34[*])C1CCC2=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17-keto steroid", "17-keto steroids", "17-ketosteroid", "17-ketosteroids", "17-oxo steroids", "17-oxosteroid", "17-oxosteroids", "a 17-oxo steroid" ; oboInOwl:id "CHEBI:19168" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "17-oxo steroid" ; rdfs:subClassOf obo:CHEBI_35789, obo:CHEBI_3992 . obo:CHEBI_194548 obo:IAO_0000115 "A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen." ; chebi:charge "0" ; chebi:formula "C9H13NO3" ; chebi:inchi "InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3" ; chebi:inchikey "UCTWMZQNUQWSLP-UHFFFAOYSA-N" ; chebi:mass "183.207" ; chebi:monoisotopicmass "183.08954" ; chebi:smiles "CNCC(O)C1=CC(O)=C(O)C=C1" ; oboInOwl:hasExactSynonym "4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:194548" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" ; rdfs:subClassOf obo:CHEBI_33567 . obo:CHEBI_20067 obo:IAO_0000115 "A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics." ; chebi:charge "0" ; chebi:formula "C4H8O3" ; chebi:inchi "InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)" ; chebi:inchikey "WHBMMWSBFZVSSR-UHFFFAOYSA-N" ; chebi:mass "104.10452" ; chebi:monoisotopicmass "104.04734" ; chebi:smiles "CC(O)CC(O)=O" ; oboInOwl:hasDbXref "Beilstein:773861", "CAS:300-85-6", "HMDB:HMDB0000357", "LIPID_MAPS_instance:LMFA01050005", "PMID:10855969", "PMID:17190852", "PMID:17579249", "PMID:6061736", "Reaxys:773861", "Wikipedia:3-hydroxybutyrate" ; oboInOwl:hasExactSynonym "3-hydroxybutanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(1)-3-Hydroxybutyric acid", "3 HBA", "3-Hydroxybuttersaeure", "3-OH-butyric acid", "BHBA", "DL-beta-Hydroxybutyric acid", "beta-Hydroxy-n-butyric acid", "beta-Hydroxybuttersaeure", "beta-hydroxy-n-butyric acid", "beta-hydroxybutanoic acid", "beta-hydroxybutyric acid" ; oboInOwl:id "CHEBI:20067" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxybutyric acid" ; rdfs:subClassOf obo:CHEBI_24684, obo:CHEBI_35969, obo:CHEBI_78954, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_37054 ] . obo:CHEBI_20106 obo:IAO_0000115 "An aromatic ether that is the 3-O-methyl ether of 3,4-dihydroxymandelic acid." ; chebi:charge "0" ; chebi:formula "C9H10O5" ; chebi:inchi "InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)" ; chebi:inchikey "CGQCWMIAEPEHNQ-UHFFFAOYSA-N" ; chebi:mass "198.17270" ; chebi:monoisotopicmass "198.05282" ; chebi:smiles "COc1cc(ccc1O)C(O)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:2213227", "CAS:55-10-7", "HMDB:HMDB0000291", "KEGG:C05584", "MetaCyc:VANILLYL_MANDELATE", "PMID:13756637", "PMID:23112240", "PMID:23399766", "PMID:23830883", "PMID:24327171", "Reaxys:2213227", "Wikipedia:Vanillylmandelic_acid" ; oboInOwl:hasExactSynonym "2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid", "Vanillylmandelic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-methoxy-4-hydroxymandelic acid", "Vanilmandelic acid", "hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid" ; oboInOwl:id "CHEBI:20106" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vanillylmandelic acid" ; rdfs:subClassOf obo:CHEBI_33853, obo:CHEBI_35618, obo:CHEBI_49302, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35825 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27622 ] . obo:CHEBI_20392 obo:IAO_0000115 "A monohydroxyproline where the hydroxy group is located at the 4-position. It is found in fibrillar collagen." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)" ; chebi:inchikey "PMMYEEVYMWASQN-UHFFFAOYSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "OC1CNC(C1)C(O)=O" ; oboInOwl:hasDbXref "PMID:21988268", "PMID:24563386", "PMID:24695516", "PMID:436278", "Wikipedia:Hydroxyproline" ; oboInOwl:hasExactSynonym "4-hydroxyproline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4Hyp" ; oboInOwl:id "CHEBI:20392" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyproline" ; rdfs:subClassOf obo:CHEBI_86499, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62978 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_63137 ] . obo:CHEBI_20612 obo:IAO_0000115 "A group of heterocyclic compounds based on the 5-methyl-5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-methyltetrahydrofolates" ; oboInOwl:id "CHEBI:20612" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-methyltetrahydrofolate" ; rdfs:subClassOf obo:CHEBI_25345 . obo:CHEBI_20664 chebi:charge "0" ; chebi:formula "C24H42" ; chebi:inchi "InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18+,19+,20-,21+,22+,23+,24-/m1/s1" ; chebi:inchikey "QSHQKIURKJITMZ-OBUPQJQESA-N" ; chebi:mass "330.59028" ; chebi:monoisotopicmass "330.32865" ; chebi:smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC" ; oboInOwl:hasDbXref "Beilstein:2048472" ; oboInOwl:hasExactSynonym "5beta-cholane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:20664" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5beta-cholane" ; rdfs:subClassOf obo:CHEBI_35519 . obo:CHEBI_20702 obo:IAO_0000115 "Any aminopurine having the amino substituent at the 2-position." ; oboInOwl:hasExactSynonym "2-aminopurines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:20702" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-aminopurines" ; rdfs:subClassOf obo:CHEBI_22527 . obo:CHEBI_20706 obo:IAO_0000115 "Any compound having 6-aminopurine (adenine) as part of its structure." ; oboInOwl:hasDbXref "PMID:1646334", "PMID:18524423", "PMID:7342604" ; oboInOwl:hasExactSynonym "6-aminopurines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:20706" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "6-aminopurines" ; rdfs:subClassOf obo:CHEBI_22527 . obo:CHEBI_21241 obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CHEBI_176783 ; a owl:Class ; owl:deprecated true . obo:CHEBI_21619 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acetylneuraminate" ; oboInOwl:id "CHEBI:21619" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetylneuraminates" ; rdfs:subClassOf obo:CHEBI_21663 . obo:CHEBI_21622 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:21622" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetylneuraminic acids" ; rdfs:subClassOf obo:CHEBI_16498, obo:CHEBI_22160 . obo:CHEBI_21644 obo:IAO_0000115 "Any N-acylamino acid having L-configuration." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:21644" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-L-amino acid" ; rdfs:subClassOf obo:CHEBI_51569, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_15778 ] . obo:CHEBI_21663 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acylneuraminate" ; oboInOwl:id "CHEBI:21663" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acylneuraminates" ; rdfs:subClassOf obo:CHEBI_25506 . obo:CHEBI_21760 obo:IAO_0000115 "An amino acid derivative in which at least one of the hydrogens of the amino group has been replaced by a methyl group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-methyl-amino acids" ; oboInOwl:id "CHEBI:21760" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-methyl-amino acid" ; rdfs:subClassOf obo:CHEBI_83821 . obo:CHEBI_21766 obo:IAO_0000115 "An N-alkylglycine that is sarcosine and derivatives of sarcosine arising by replacement of the hydrogen attached to the nitrogen by a hydrocarbyl group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:21766" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-methylglycines" ; rdfs:subClassOf obo:CHEBI_66933 . obo:CHEBI_22160 obo:IAO_0000115 "Compounds with the general formula RNHC(=O)CH3." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:22160" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acetamides" ; rdfs:subClassOf obo:CHEBI_37622 . obo:CHEBI_22221 obo:IAO_0000115 "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." ; oboInOwl:hasExactSynonym "acyl group", "alkanoyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acyl groups", "alkanoyl group", "groupe acyle" ; oboInOwl:id "CHEBI:22221" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acyl group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_22299 obo:IAO_0000115 "A monocarboxylic acid anion resulting from the deprotonation of the carboxy group of an aldonic acid." ; oboInOwl:hasExactSynonym "aldonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldonates" ; oboInOwl:id "CHEBI:22299" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldonate" ; rdfs:subClassOf obo:CHEBI_33721, obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22301 ] . obo:CHEBI_22301 obo:IAO_0000115 "Any carbohydrate acid formed by oxidising the aldehyde functional group of an aldose to a carboxylic acid functional group. Aldonic acids have the general formula HOCH2[CH(OH)]nC(=O)OH." ; oboInOwl:hasExactSynonym "aldonic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldonic acids" ; oboInOwl:id "CHEBI:22301" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldonic acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_33720, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_22299 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_71671 ] . obo:CHEBI_22313 oboInOwl:hasExactSynonym "alkaline earth metals" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Erdalkalimetall", "Erdalkalimetalle", "alkaline earth metal", "alkaline-earth metal", "alkaline-earth metals", "metal alcalino-terreux", "metal alcalinoterreo", "metales alcalinoterreos", "metaux alcalino-terreux" ; oboInOwl:id "CHEBI:22313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkaline earth metal atom" ; rdfs:subClassOf obo:CHEBI_33318, obo:CHEBI_33521, obo:CHEBI_33559 . obo:CHEBI_22314 oboInOwl:hasExactSynonym "alkali metals" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alkalimetall", "Alkalimetalle", "alkali metal", "metal alcalin", "metal alcalino", "metales alcalinos", "metaux alcalins" ; oboInOwl:id "CHEBI:22314" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkali metal atom" ; rdfs:subClassOf obo:CHEBI_33318, obo:CHEBI_33521, obo:CHEBI_33559 . obo:CHEBI_22315 obo:IAO_0000115 "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." ; oboInOwl:hasDbXref "Wikipedia:Alkaloid" ; oboInOwl:hasExactSynonym "Alkaloid", "alkaloids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alkaloide", "alcaloide", "alcaloides" ; oboInOwl:id "CHEBI:22315" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkaloid" ; rdfs:subClassOf obo:CHEBI_35352, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ] . obo:CHEBI_22323 obo:IAO_0000115 "A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom." ; oboInOwl:hasExactSynonym "alkyl group", "alkyl groups" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "groupe alkyle", "grupo alquilo", "grupos alquilo" ; oboInOwl:id "CHEBI:22323" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkyl group" ; rdfs:subClassOf obo:CHEBI_33248, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_18310 ] . obo:CHEBI_22331 obo:IAO_0000115 "Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:22331" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkylamines" ; rdfs:subClassOf obo:CHEBI_32952 . obo:CHEBI_22478 obo:IAO_0000115 "An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino alcohols", "aminoalcohol", "aminoalcohols" ; oboInOwl:id "CHEBI:22478" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino alcohol" ; rdfs:subClassOf obo:CHEBI_30879, obo:CHEBI_50047 . obo:CHEBI_22480 obo:IAO_0000115 "A disaccharide derivative that is a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino-disaccharides" ; oboInOwl:id "CHEBI:22480" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino disaccharide" ; rdfs:subClassOf obo:CHEBI_22483, obo:CHEBI_63353 . obo:CHEBI_22483 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino oligosaccharides" ; oboInOwl:id "CHEBI:22483" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino oligosaccharide" ; rdfs:subClassOf obo:CHEBI_63563 . obo:CHEBI_22484 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "galactosamine oligosaccharides" ; oboInOwl:id "CHEBI:22484" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactosamine oligosaccharide" ; rdfs:subClassOf obo:CHEBI_22483 . obo:CHEBI_22494 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aminobenzoates" ; oboInOwl:id "CHEBI:22494" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aminobenzoate" ; rdfs:subClassOf obo:CHEBI_22718, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22495 ] . obo:CHEBI_22495 chebi:charge "0" ; chebi:formula "C7H7NO2" ; chebi:mass "137.136" ; chebi:monoisotopicmass "137.04768" ; oboInOwl:hasExactSynonym "aminobenzoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aminobenzoesaeure" ; oboInOwl:id "CHEBI:22495" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aminobenzoic acid" ; rdfs:subClassOf obo:CHEBI_22723, obo:CHEBI_33856, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_22494 ] . obo:CHEBI_22506 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aminoglycans" ; oboInOwl:id "CHEBI:22506" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aminoglycan" ; rdfs:subClassOf obo:CHEBI_35352, obo:CHEBI_65212 . obo:CHEBI_22527 obo:IAO_0000115 "Any purine having at least one amino substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aminopurines" ; oboInOwl:id "CHEBI:22527" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aminopurine" ; rdfs:subClassOf obo:CHEBI_26401 . obo:CHEBI_22558 obo:IAO_0000115 "Intramolecular ethers formally arising by elimination of water from two hydroxy groups of a single molecule of a monosaccharide (aldose or ketose) or monosaccharide derivative." ; oboInOwl:hasExactSynonym "anhydro sugar" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anhydro sugars", "anhydrosugars", "sugar anhydride", "sugar anhydrides" ; oboInOwl:id "CHEBI:22558" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anhydro sugar" ; rdfs:subClassOf obo:CHEBI_35381 . obo:CHEBI_22563 obo:IAO_0000115 "A monoatomic or polyatomic species having one or more elementary charges of the electron." ; oboInOwl:hasExactSynonym "Anion", "anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Anionen", "aniones", "anions" ; oboInOwl:id "CHEBI:22563" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anion" ; rdfs:subClassOf obo:CHEBI_24870 . obo:CHEBI_22586 obo:IAO_0000115 "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antioxidants", "antioxydant", "antoxidant" ; oboInOwl:id "CHEBI:22586" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antioxidant" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_22587 obo:IAO_0000115 "A substance that destroys or inhibits replication of viruses." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-viral agent", "anti-viral agents", "antiviral", "antiviral agents", "antivirals" ; oboInOwl:id "CHEBI:22587" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antiviral agent" ; rdfs:subClassOf obo:CHEBI_33281 . obo:CHEBI_22653 obo:IAO_0000115 "An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group." ; chebi:charge "0" ; chebi:formula "C4H8N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)" ; chebi:inchikey "DCXYFEDJOCDNAF-UHFFFAOYSA-N" ; chebi:mass "132.11800" ; chebi:monoisotopicmass "132.05349" ; chebi:smiles "NC(CC(N)=O)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:1723525", "CAS:3130-87-8", "Gmelin:279043", "KEGG:C16438", "PMID:22264337", "PMID:22770225", "Reaxys:1723525", "Wikipedia:Asparagine" ; oboInOwl:hasExactSynonym "asparagine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,4-diamino-4-oxobutanoic acid", "2-amino-3-carbamoylpropanoic acid", "ASN", "Asn", "Asparagin", "DL-Asparagine", "Hasp", "N", "asparagina" ; oboInOwl:id "CHEBI:22653" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "asparagine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_35735, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50330 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32660 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32661 ] . obo:CHEBI_22658 obo:IAO_0000115 "An L-alpha-amino acid which is L-aspartic acid or any of the essential amino acids biosynthesised from it (asparagine, lysine, methionine, threonine and isoleucine). A closed class." ; oboInOwl:hasDbXref "PMID:4386082", "PMID:4394351", "PMID:4721772", "PMID:5016260", "PMID:5074276" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aspartate family amino acids", "aspartic acid family amino acid", "aspartic acid family amino acids", "oxaloacetate family amino acid", "oxaloacetate family amino acids", "oxaloacetate/aspartate family amino acid", "oxaloacetate/aspartate family amino acids" ; oboInOwl:id "CHEBI:22658" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aspartate family amino acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_83813 . obo:CHEBI_22660 obo:IAO_0000115 "An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent" ; chebi:charge "0" ; chebi:formula "C4H7NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)" ; chebi:inchikey "CKLJMWTZIZZHCS-UHFFFAOYSA-N" ; chebi:mass "133.10272" ; chebi:monoisotopicmass "133.03751" ; chebi:smiles "NC(CC(O)=O)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:774618", "CAS:617-45-8", "Gmelin:185140", "KEGG:C16433", "PMID:22264337", "Reaxys:774618", "Wikipedia:Aspartic_acid" ; oboInOwl:hasExactSynonym "Aspartic acid", "aspartic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+-)-Aspartic acid", "(R,S)-Aspartic acid", "2-aminobutanedioic acid", "Asp", "D", "DL-Aminosuccinic acid", "DL-Asparagic acid" ; oboInOwl:id "CHEBI:22660" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aspartic acid" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_66873, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_41402 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132943 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35391 ] . obo:CHEBI_22676 obo:IAO_0000115 "Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, \"to grow\")." ; oboInOwl:hasDbXref "Wikipedia:Auxin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "auxins" ; oboInOwl:id "CHEBI:22676" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "auxin" ; rdfs:subClassOf obo:CHEBI_37848 . obo:CHEBI_22695 obo:IAO_0000115 "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." ; oboInOwl:hasDbXref "KEGG:C00701" ; oboInOwl:hasExactSynonym "Base", "base" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Base1", "Base2", "Basen", "Nucleobase", "bases" ; oboInOwl:id "CHEBI:22695" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "base" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_22712 obo:IAO_0000115 "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:22712" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzenes" ; rdfs:subClassOf obo:CHEBI_33836 . obo:CHEBI_22718 obo:IAO_0000115 "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "benzoate anion" ; oboInOwl:id "CHEBI:22718" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzoates" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_91007 . obo:CHEBI_22723 obo:IAO_0000115 "Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:22723" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzoic acids" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_33859 . obo:CHEBI_22727 oboInOwl:hasDbXref "Wikipedia:Benzopyran" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "benzopyrans" ; oboInOwl:id "CHEBI:22727" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzopyran" ; rdfs:subClassOf obo:CHEBI_38104, obo:CHEBI_38166 . obo:CHEBI_22728 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "benzopyrroles" ; oboInOwl:id "CHEBI:22728" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzopyrrole" ; rdfs:subClassOf obo:CHEBI_27171, obo:CHEBI_38101, obo:CHEBI_38180 . obo:CHEBI_22744 chebi:charge "0" ; chebi:formula "C7H7" ; chebi:mass "91.13048" ; chebi:monoisotopicmass "91.05478" ; chebi:smiles "C1=C(C=CC=C1)C*" ; oboInOwl:hasExactSynonym "benzyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Bn", "C6H5-CH2-", "phenylalanine side-chain", "phenylmethyl" ; oboInOwl:id "CHEBI:22744" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzyl group" ; rdfs:subClassOf obo:CHEBI_33452, obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_17578 ] . obo:CHEBI_22860 obo:IAO_0000115 "Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino acid betaines", "amino-acid betaines", "betaines" ; oboInOwl:id "CHEBI:22860" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino-acid betaine" ; rdfs:subClassOf obo:CHEBI_35284, obo:CHEBI_83821 . obo:CHEBI_22868 obo:IAO_0000115 "A sodium salt of the conjugate of any bile acid with either glycine or taurine." ; oboInOwl:hasDbXref "KEGG:C01558" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Bile acid", "bile salts" ; oboInOwl:id "CHEBI:22868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bile salt" ; rdfs:subClassOf obo:CHEBI_36078, obo:CHEBI_38700 . obo:CHEBI_22881 oboInOwl:hasDbXref "MetaCyc:All-Biopterines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:22881" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biopterins" ; rdfs:subClassOf obo:CHEBI_26375 . obo:CHEBI_22918 obo:IAO_0000115 "Any amino acid in which the parent hydrocarbon chain has one or more alkyl substituents" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "branched chain amino acids" ; oboInOwl:id "CHEBI:22918" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain amino acid" ; rdfs:subClassOf obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63471 ] . obo:CHEBI_22984 chebi:charge "0" ; chebi:formula "Ca" ; chebi:inchi "InChI=1S/Ca" ; chebi:inchikey "OYPRJOBELJOOCE-UHFFFAOYSA-N" ; chebi:mass "40.07800" ; chebi:monoisotopicmass "39.96259" ; chebi:smiles "[Ca]" ; oboInOwl:hasDbXref "CAS:7440-70-2", "DrugBank:DB01373", "KEGG:C00076", "WebElements:Ca" ; oboInOwl:hasExactSynonym "calcium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "20Ca", "Ca", "Calcium", "Kalzium", "calcio", "calcium" ; oboInOwl:id "CHEBI:22984" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calcium atom" ; rdfs:subClassOf obo:CHEBI_22313, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_23004 obo:IAO_0000115 "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." ; chebi:charge "0" ; chebi:formula "CH2NO" ; chebi:mass "44.03272" ; chebi:monoisotopicmass "44.01364" ; chebi:smiles "*C(N)=O" ; oboInOwl:hasDbXref "PMID:24168430" ; oboInOwl:hasExactSynonym "carbamoyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-C(O)NH2", "-CONH2", "aminocarbonyl", "carbamyl", "carbamyl group", "carboxamide" ; oboInOwl:id "CHEBI:23004" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbamoyl group" ; rdfs:subClassOf obo:CHEBI_27207, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_28616 ] . obo:CHEBI_23014 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbon oxides", "oxides of carbon" ; oboInOwl:id "CHEBI:23014" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon oxide" ; rdfs:subClassOf obo:CHEBI_25701, obo:CHEBI_36963 . obo:CHEBI_23019 chebi:charge "0" ; chebi:formula "CO" ; chebi:mass "28.01010" ; chebi:monoisotopicmass "27.99491" ; chebi:smiles "O=C(*)*" ; oboInOwl:hasExactSynonym "carbonyl", "carbonyl group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym ">C=O" ; oboInOwl:id "CHEBI:23019" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbonyl group" ; rdfs:subClassOf obo:CHEBI_51422 . obo:CHEBI_23042 obo:IAO_0000115 "Hydrocarbon carotenoids." ; oboInOwl:hasExactSynonym "carotene", "carotenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carotenes" ; oboInOwl:id "CHEBI:23042" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carotene" ; rdfs:subClassOf obo:CHEBI_35193 . obo:CHEBI_23044 obo:IAO_0000115 "One of a class of tetraterpenoids (C40), formally derived from the acyclic parent, psi,psi-carotene by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these processes. This class includes carotenes, xanthophylls and certain compounds that arise from rearrangement of the skeleton of psi,psi-carotene or by loss of part of this structure. Retinoids are excluded." ; oboInOwl:hasDbXref "CAS:36-88-4" ; oboInOwl:hasExactSynonym "carotenoid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carotenes and carotenoids", "carotenoids" ; oboInOwl:id "CHEBI:23044" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carotenoid" ; rdfs:subClassOf obo:CHEBI_26935, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_23042 ] . obo:CHEBI_23045 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carotenols", "hydroxycarotenoids" ; oboInOwl:id "CHEBI:23045" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carotenol" ; rdfs:subClassOf obo:CHEBI_27325 . obo:CHEBI_23075 obo:IAO_0000115 "An oligoglycosylceramide consisting of a glycotetraosyl moiety attached to the ceramide oxygen with an unspecified N-acyl substituent attached to the ceramide nitrogen." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycotetraosylceramides" ; oboInOwl:id "CHEBI:23075" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycotetraosylceramide" ; rdfs:subClassOf obo:CHEBI_36520 . obo:CHEBI_23116 chebi:charge "0" ; chebi:formula "Cl" ; chebi:inchi "InChI=1S/Cl" ; chebi:inchikey "ZAMOUSCENKQFHK-UHFFFAOYSA-N" ; chebi:mass "35.45270" ; chebi:monoisotopicmass "34.96885" ; chebi:smiles "[Cl]" ; oboInOwl:hasDbXref "WebElements:Cl" ; oboInOwl:hasExactSynonym "chlorine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17Cl", "Chlor", "Cl", "chlore", "chlorine", "chlorum", "cloro" ; oboInOwl:id "CHEBI:23116" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chlorine atom" ; rdfs:subClassOf obo:CHEBI_24473, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ] . obo:CHEBI_23117 obo:IAO_0000115 "A halogen molecular entity containing one or more atoms of chlorine." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23117" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chlorine molecular entity" ; rdfs:subClassOf obo:CHEBI_24471, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_23116 ] . obo:CHEBI_23229 obo:IAO_0000115 "Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23229" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chromanol" ; rdfs:subClassOf obo:CHEBI_23230, obo:CHEBI_33822 . obo:CHEBI_23230 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23230" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chromanes" ; rdfs:subClassOf obo:CHEBI_38443 . obo:CHEBI_23240 obo:IAO_0000115 "The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized." ; oboInOwl:hasDbXref "Wikipedia:Chromophore" ; oboInOwl:hasExactSynonym "chromophore" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chromophores" ; oboInOwl:id "CHEBI:23240" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chromophore" ; rdfs:subClassOf obo:CHEBI_52215 . obo:CHEBI_23324 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23324" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "citrullines" ; rdfs:subClassOf obo:CHEBI_83925 . obo:CHEBI_23333 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23333" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cob(III)alamins" ; rdfs:subClassOf obo:CHEBI_23334 . obo:CHEBI_23334 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23334" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalamins" ; rdfs:subClassOf obo:CHEBI_176843, obo:CHEBI_23341 . obo:CHEBI_23341 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23341" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "cobamides" ; rdfs:subClassOf obo:CHEBI_23390 . obo:CHEBI_23354 obo:IAO_0000115 "A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons." ; oboInOwl:hasExactSynonym "coenzyme" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "coenzymes" ; oboInOwl:id "CHEBI:23354" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "coenzyme" ; rdfs:subClassOf obo:CHEBI_23357 . obo:CHEBI_23357 obo:IAO_0000115 "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." ; oboInOwl:hasDbXref "Wikipedia:Cofactor_(biochemistry)" ; oboInOwl:hasExactSynonym "cofactor", "cofactors" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23357" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cofactor" ; rdfs:subClassOf obo:CHEBI_52206 . obo:CHEBI_23366 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23366" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "compatible osmolytes" ; rdfs:subClassOf obo:CHEBI_25728 . obo:CHEBI_23367 obo:IAO_0000115 "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ; oboInOwl:hasExactSynonym "molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "entidad molecular", "entidades moleculares", "entite moleculaire", "molecular entities", "molekulare Entitaet" ; oboInOwl:id "CHEBI:23367" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "molecular entity" ; rdfs:subClassOf obo:CHEBI_24431 . obo:CHEBI_23390 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23390" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "cobalt-corrinoid hexaamide" ; rdfs:subClassOf obo:CHEBI_33906 . obo:CHEBI_23443 oboInOwl:hasAlternativeId "CHEBI:3990" ; oboInOwl:hasExactSynonym "cyclic amide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic amides" ; oboInOwl:id "CHEBI:23443" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic amide" ; rdfs:subClassOf obo:CHEBI_32988 . obo:CHEBI_23449 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Cyclopeptid", "Zyklopeptid", "cyclic peptides", "peptide cyclique", "peptido ciclico" ; oboInOwl:id "CHEBI:23449" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic peptide" ; rdfs:subClassOf obo:CHEBI_16670 . obo:CHEBI_23505 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23505" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "cystathionines" ; rdfs:subClassOf obo:CHEBI_24610 . obo:CHEBI_23509 obo:IAO_0000115 "An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues." ; oboInOwl:hasAlternativeId "CHEBI:25309" ; oboInOwl:hasExactSynonym "cysteine derivative" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cysteine derivatives" ; oboInOwl:id "CHEBI:23509" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteine derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15356 ] . obo:CHEBI_23622 oboInOwl:hasExactSynonym "deoxygalactose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "deoxygalactoses" ; oboInOwl:id "CHEBI:23622" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "deoxygalactose" ; rdfs:subClassOf obo:CHEBI_23628 . obo:CHEBI_23628 obo:IAO_0000115 "Any C6 deoxy sugar having at least one hydroxy group replaced by hydrogen." ; oboInOwl:hasExactSynonym "deoxyhexose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "deoxyhexoses" ; oboInOwl:id "CHEBI:23628" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "deoxyhexose" ; rdfs:subClassOf obo:CHEBI_23639, obo:CHEBI_33917 . obo:CHEBI_23639 obo:IAO_0000115 "Any sugar having a hydroxy group replaced with a hydrogen atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "deoxy sugars", "deoxysugar", "deoxysugars" ; oboInOwl:id "CHEBI:23639" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "deoxy sugar" ; rdfs:subClassOf obo:CHEBI_16646 . obo:CHEBI_23677 obo:IAO_0000115 "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "diazoles" ; oboInOwl:id "CHEBI:23677" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diazole" ; rdfs:subClassOf obo:CHEBI_68452 . obo:CHEBI_23690 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acid amides" ; oboInOwl:id "CHEBI:23690" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid amide" ; rdfs:subClassOf obo:CHEBI_37622 . obo:CHEBI_23824 obo:IAO_0000115 "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." ; oboInOwl:hasDbXref "Wikipedia:Diol" ; oboInOwl:hasExactSynonym "diols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:23824" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diol" ; rdfs:subClassOf obo:CHEBI_26191 . obo:CHEBI_23849 obo:IAO_0000115 "Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMPR0104" ; oboInOwl:hasExactSynonym "diterpenoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C20 isoprenoids", "diterpenoides" ; oboInOwl:id "CHEBI:23849" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diterpenoid" ; rdfs:subClassOf obo:CHEBI_26873, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35190 ] . obo:CHEBI_23888 obo:IAO_0000115 "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "drugs", "medicine" ; oboInOwl:id "CHEBI:23888" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "drug" ; rdfs:subClassOf obo:CHEBI_52217 . obo:CHEBI_23899 obo:IAO_0000115 "Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA)." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMFA03", "PMID:12697726", "PMID:16107763", "PMID:19160658", "PMID:2657063", "Wikipedia:Eicosanoid" ; oboInOwl:hasExactSynonym "icosanoid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "eicosanoid", "eicosanoids", "icosanoids" ; oboInOwl:id "CHEBI:23899" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "icosanoid" ; rdfs:subClassOf obo:CHEBI_61697, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62937 ] . obo:CHEBI_23905 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic anions" ; oboInOwl:id "CHEBI:23905" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic anion" ; rdfs:subClassOf obo:CHEBI_22563, obo:CHEBI_24867 . obo:CHEBI_23906 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic cations" ; oboInOwl:id "CHEBI:23906" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic cation" ; rdfs:subClassOf obo:CHEBI_24867, obo:CHEBI_36916 . obo:CHEBI_23924 obo:IAO_0000115 "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." ; oboInOwl:hasExactSynonym "enzyme inhibitor" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "enzyme inhibitors", "inhibidor enzimatico", "inhibidores enzimaticos", "inhibiteur enzymatique", "inhibiteurs enzymatiques" ; oboInOwl:id "CHEBI:23924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "enzyme inhibitor" ; rdfs:subClassOf obo:CHEBI_35222, obo:CHEBI_52206 . obo:CHEBI_23965 obo:IAO_0000115 "A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17." ; chebi:charge "0" ; chebi:formula "C18H24O2" ; chebi:inchi "InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17?,18+/m1/s1" ; chebi:inchikey "VOXZDWNPVJITMN-WKUFJEKOSA-N" ; chebi:mass "272.38196" ; chebi:monoisotopicmass "272.17763" ; chebi:smiles "[H][C@]12CC[C@]3(C)C(O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21" ; oboInOwl:hasAlternativeId "CHEBI:42364" ; oboInOwl:hasDbXref "PMID:10696569", "PMID:24084694", "Wikipedia:Estradiol" ; oboInOwl:hasExactSynonym "estra-1,3,5(10)-triene-3,17-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oestradiol" ; oboInOwl:id "CHEBI:23965" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "estradiol" ; rdfs:subClassOf obo:CHEBI_177917, obo:CHEBI_36834, obo:CHEBI_36838, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50114 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_23966 ] . obo:CHEBI_23966 chebi:charge "0" ; chebi:formula "C18H30" ; chebi:inchi "InChI=1S/C18H30/c1-18-11-4-7-17(18)16-9-8-13-5-2-3-6-14(13)15(16)10-12-18/h13-17H,2-12H2,1H3/t13?,14-,15+,16+,17-,18-/m0/s1" ; chebi:inchikey "GRXPVLPQNMUNNX-MHJRRCNVSA-N" ; chebi:mass "246.43080" ; chebi:monoisotopicmass "246.23475" ; chebi:smiles "[H][C@]12CCCCC1CC[C@]1([H])[C@]2([H])CC[C@]2(C)CCC[C@@]12[H]" ; oboInOwl:hasDbXref "Beilstein:3125721", "LIPID_MAPS_instance:LMST02010000" ; oboInOwl:hasExactSynonym "estrane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Oestran", "oestrane" ; oboInOwl:id "CHEBI:23966" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "estrane" ; rdfs:subClassOf obo:CHEBI_35508 . obo:CHEBI_23981 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ethanolamine" ; oboInOwl:id "CHEBI:23981" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ethanolamines" ; rdfs:subClassOf obo:CHEBI_22478 . obo:CHEBI_24020 obo:IAO_0000115 "Any vitamin that dissolves in fats and are stored in body tissues. Unlike the water-soluble vitamins, they are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess." ; oboInOwl:hasDbXref "PMID:31838543", "PMID:32057251", "PMID:33549284", "PMID:34045883" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fat-soluble vitamin", "fat-soluble vitamins", "fettloesliche Vitamine" ; oboInOwl:id "CHEBI:24020" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fat-soluble vitamin (role)" ; rdfs:subClassOf obo:CHEBI_33229 . obo:CHEBI_24148 chebi:charge "0" ; chebi:formula "C6H11O7" ; chebi:mass "195.148" ; chebi:monoisotopicmass "195.05048" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24148" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactonate" ; rdfs:subClassOf obo:CHEBI_33778, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_24149 ] . obo:CHEBI_24149 obo:IAO_0000115 "A hexonic acid that has been found to increase in red blood cells of galactosemic patients." ; chebi:charge "0" ; chebi:formula "C6H12O7" ; chebi:mass "196.156" ; chebi:monoisotopicmass "196.05830" ; oboInOwl:hasDbXref "PMID:14680973" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24149" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactonic acid" ; rdfs:subClassOf obo:CHEBI_33752, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_24148 ] . obo:CHEBI_24163 oboInOwl:hasExactSynonym "galactoside" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "galactosides" ; oboInOwl:id "CHEBI:24163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactoside" ; rdfs:subClassOf obo:CHEBI_35313 . obo:CHEBI_24261 obo:IAO_0000115 "Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glucocorticoids" ; oboInOwl:id "CHEBI:24261" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucocorticoid" ; rdfs:subClassOf obo:CHEBI_36699 . obo:CHEBI_24280 obo:IAO_0000115 "The glucosyl group formed from D-glucopyranose." ; chebi:charge "0" ; chebi:formula "C6H11O5" ; chebi:mass "163.14850" ; chebi:monoisotopicmass "163.06065" ; chebi:smiles "C1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)*" ; oboInOwl:hasExactSynonym "D-glucopyranosyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-glucopyranosyl group", "glucopyranosyl group", "glucosyl group" ; oboInOwl:id "CHEBI:24280" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glucosyl group" ; rdfs:subClassOf obo:CHEBI_24281, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_4167 ] . obo:CHEBI_24281 obo:IAO_0000115 "A glycosyl group obtained by removing the hydroxy group from the hemiacetal function of a glucose and, by extension, of a lower oligosaccharide having glucose at the reducing end." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glucosyl groups" ; oboInOwl:id "CHEBI:24281" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucosyl group" ; rdfs:subClassOf obo:CHEBI_24403 . obo:CHEBI_24315 obo:IAO_0000115 "An amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24315" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamic acid derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_18237 ] . obo:CHEBI_24318 obo:IAO_0000115 "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." ; oboInOwl:hasDbXref "PMID:20716061" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutamine family amino acids" ; oboInOwl:id "CHEBI:24318" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamine family amino acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_83813 . obo:CHEBI_24319 obo:IAO_0000115 "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)." ; oboInOwl:hasDbXref "Wikipedia:Glutamine_synthetase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors", "EC 6.3.1.2 inhibitor", "EC 6.3.1.2 inhibitors", "L-glutamate:ammonia ligase (ADP-forming) inhibitor", "L-glutamate:ammonia ligase (ADP-forming) inhibitors", "L-glutamine synthetase inhibitor", "L-glutamine synthetase inhibitors", "glutamate--ammonia ligase (EC 6.3.1.2) inhibitor", "glutamate--ammonia ligase (EC 6.3.1.2) inhibitors", "glutamate--ammonia ligase inhibitor", "glutamate--ammonia ligase inhibitors", "glutamine synthetase inhibitor", "glutamine synthetase inhibitors", "glutamylhydroxamic synthetase inhibitor", "glutamylhydroxamic synthetase inhibitors" ; oboInOwl:id "CHEBI:24319" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76823 . obo:CHEBI_24329 obo:IAO_0000115 "A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of glutaric acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutarate anion", "glutarates", "glutaric acid anion" ; oboInOwl:id "CHEBI:24329" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutarate" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17859 ] . obo:CHEBI_24373 obo:IAO_0000115 "A proteinogenic amino acid derivative resulting from reaction of glycine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24373" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine derivative" ; rdfs:subClassOf obo:CHEBI_83811, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15428 ] . obo:CHEBI_24384 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24384" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycogens" ; rdfs:subClassOf obo:CHEBI_37163 . obo:CHEBI_24396 obo:IAO_0000115 "Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide." ; oboInOwl:hasAlternativeId "CHEBI:24395", "CHEBI:5478" ; oboInOwl:hasExactSynonym "glycopeptides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24396" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycopeptide" ; rdfs:subClassOf obo:CHEBI_16670, obo:CHEBI_63299 . obo:CHEBI_24400 obo:IAO_0000115 "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." ; oboInOwl:hasExactSynonym "glycosides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "O-glycoside", "O-glycosides", "glycosides" ; oboInOwl:id "CHEBI:24400" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycoside" ; rdfs:subClassOf obo:CHEBI_63161 . obo:CHEBI_24402 obo:IAO_0000115 "A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid." ; oboInOwl:hasAlternativeId "CHEBI:5498" ; oboInOwl:hasDbXref "PMID:18845618", "PMID:19303901", "PMID:26954668", "PMID:26976737", "PMID:27253729", "PMID:27325407", "Wikipedia:Glycosphingolipid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycosphingolipids" ; oboInOwl:id "CHEBI:24402" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycosphingolipid" ; rdfs:subClassOf obo:CHEBI_26739, obo:CHEBI_33563 . obo:CHEBI_24403 obo:IAO_0000115 "An organic group obtained by removing the hydroxy group from the hemiacetal function of a monosaccharide or monosaccharide derivative and, by extension, of a lower oligosaccharide or oligosaccharide derivative." ; oboInOwl:hasExactSynonym "glycosyl group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycosyl groups", "groupe glycosyle" ; oboInOwl:id "CHEBI:24403" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycosyl group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_24431 obo:IAO_0000115 "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." ; oboInOwl:hasExactSynonym "chemical entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24431" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chemical entity" . obo:CHEBI_24432 obo:IAO_0000115 "A role played by the molecular entity or part thereof within a biological context." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "biological function" ; oboInOwl:id "CHEBI:24432" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biological role" ; rdfs:subClassOf obo:CHEBI_50906 . obo:CHEBI_24433 obo:IAO_0000115 "A defined linked collection of atoms or a single atom within a molecular entity." ; oboInOwl:hasExactSynonym "group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Gruppe", "Rest", "groupe", "grupo", "grupos" ; oboInOwl:id "CHEBI:24433" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "group" ; rdfs:subClassOf obo:CHEBI_24431, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33250 ] . obo:CHEBI_24436 obo:IAO_0000115 "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24436" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "guanidines" ; rdfs:subClassOf obo:CHEBI_35352 . obo:CHEBI_24470 obo:IAO_0000115 "Any non-proteinogenic amino acid carrying at least one halo group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "haloamino acids" ; oboInOwl:id "CHEBI:24470" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "haloamino acid" ; rdfs:subClassOf obo:CHEBI_83820 . obo:CHEBI_24471 oboInOwl:hasExactSynonym "halogen molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "halogen compounds", "halogen molecular entities" ; oboInOwl:id "CHEBI:24471" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "halogen molecular entity" ; rdfs:subClassOf obo:CHEBI_33675, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_24473 ] . obo:CHEBI_24473 oboInOwl:hasExactSynonym "halogen", "halogens" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Halogene", "group 17 elements", "group VII elements", "halogene", "halogenes", "halogeno", "halogenos" ; oboInOwl:id "CHEBI:24473" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "halogen" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33560 . obo:CHEBI_24500 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heparans" ; oboInOwl:id "CHEBI:24500" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heparan" ; rdfs:subClassOf obo:CHEBI_18085 . obo:CHEBI_24532 obo:IAO_0000115 "A cyclic compound having as ring members atoms of carbon and at least of one other element." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic heterocycle", "organic heterocyclic compounds" ; oboInOwl:id "CHEBI:24532" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic heterocyclic compound" ; rdfs:subClassOf obo:CHEBI_33285, obo:CHEBI_33832, obo:CHEBI_5686 . obo:CHEBI_24533 obo:IAO_0000115 "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." ; oboInOwl:hasExactSynonym "heterodetic cyclic peptide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heterodetic cyclic peptides", "peptide cyclique heterodetique", "peptido ciclico heterodetico" ; oboInOwl:id "CHEBI:24533" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heterodetic cyclic peptide" ; rdfs:subClassOf obo:CHEBI_23449 . obo:CHEBI_24583 oboInOwl:hasExactSynonym "hexitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hexitols" ; oboInOwl:id "CHEBI:24583" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexitol" ; rdfs:subClassOf obo:CHEBI_17522 . obo:CHEBI_24599 obo:IAO_0000115 "An amino acid derivative resulting from reaction of histidine at the amino group or the carboxy group, or from the replacement of any hydrogen of histidine by a heteroatom. The definition normally excludes peptides containing alanine residues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "histidine derivatives" ; oboInOwl:id "CHEBI:24599" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidine derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_27570 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66998 ] . obo:CHEBI_24610 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24610" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "homocysteines" ; rdfs:subClassOf obo:CHEBI_83925 . obo:CHEBI_24612 obo:IAO_0000115 "A non-proteinogenic alpha-amino acid obtained by oxidative dimerisation of homocysteine and its derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24612" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homocystines" ; rdfs:subClassOf obo:CHEBI_26834, obo:CHEBI_35489, obo:CHEBI_83925 . obo:CHEBI_24621 obo:IAO_0000115 "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "endocrine", "hormones" ; oboInOwl:id "CHEBI:24621" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hormone" ; rdfs:subClassOf obo:CHEBI_33280, obo:CHEBI_48705 . obo:CHEBI_24628 obo:IAO_0000115 "An imidazolidinone with oxo groups at position 2 and 4." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24628" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidazolidine-2,4-dione" ; rdfs:subClassOf obo:CHEBI_55370 . obo:CHEBI_24632 obo:IAO_0000115 "A compound consisting of carbon and hydrogen only." ; oboInOwl:hasExactSynonym "hydrocarbon", "hydrocarbons" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Kohlenwasserstoff", "Kohlenwasserstoffe", "hidrocarburo", "hidrocarburos", "hydrocarbure" ; oboInOwl:id "CHEBI:24632" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrocarbon" ; rdfs:subClassOf obo:CHEBI_33245 . obo:CHEBI_24651 obo:IAO_0000115 "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24651" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxides" ; rdfs:subClassOf obo:CHEBI_25806, obo:CHEBI_33608, obo:CHEBI_37577, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_43176 ] . obo:CHEBI_24654 obo:IAO_0000115 "Any fatty acid carrying one or more hydroxy substituents." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMFA0105", "PMID:18296335", "PMID:6419288", "PMID:8274032" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy fatty acids" ; oboInOwl:id "CHEBI:24654" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, obo:CHEBI_35868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59835 ] . obo:CHEBI_24662 obo:IAO_0000115 "A non-proteinogenic alpha-amino acid bearing one or more hydroxy groups at unspecified positions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24662" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy-amino acid" ; rdfs:subClassOf obo:CHEBI_83925 . obo:CHEBI_24663 obo:IAO_0000115 "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy-5beta-cholanic acids" ; oboInOwl:id "CHEBI:24663" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy-5beta-cholanic acid" ; rdfs:subClassOf obo:CHEBI_33822, obo:CHEBI_36248, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_36238 ] . obo:CHEBI_24669 obo:IAO_0000115 "Any carboxylic acid with at least one hydroxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy carboxylic acids", "hydroxycarboxylic acid", "hydroxycarboxylic acids" ; oboInOwl:id "CHEBI:24669" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy carboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_33822 . obo:CHEBI_24684 obo:IAO_0000115 "Any compound comprising a butyric acid core carrying at least one hydroxy substituent." ; chebi:charge "0" ; chebi:formula "C4H8O3" ; chebi:mass "104.105" ; chebi:monoisotopicmass "104.04734" ; oboInOwl:hasExactSynonym "hydroxybutanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxybutanoic acids", "hydroxybutyric acids" ; oboInOwl:id "CHEBI:24684" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxybutyric acid" ; rdfs:subClassOf obo:CHEBI_24654, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ] . obo:CHEBI_24712 chebi:charge "0" ; chebi:formula "CH3O" ; chebi:mass "31.03392" ; chebi:monoisotopicmass "31.01839" ; chebi:smiles "C(*)O" ; oboInOwl:hasExactSynonym "hydroxymethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-CH2-OH", "serine side-chain" ; oboInOwl:id "CHEBI:24712" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxymethyl group" ; rdfs:subClassOf obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_17790 ] . obo:CHEBI_24741 obo:IAO_0000115 "A proline derivative that is proline substituted by at least one hydroxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxyprolines" ; oboInOwl:id "CHEBI:24741" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxyproline" ; rdfs:subClassOf obo:CHEBI_24662, obo:CHEBI_26273, obo:CHEBI_46701, obo:CHEBI_46773 . obo:CHEBI_24780 obo:IAO_0000115 "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24780" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidazoles" ; rdfs:subClassOf obo:CHEBI_23677 . obo:CHEBI_24828 obo:IAO_0000115 "Any compound containing an indole skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24828" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "indoles" ; rdfs:subClassOf obo:CHEBI_22728 . obo:CHEBI_24833 obo:IAO_0000115 "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." ; oboInOwl:hasExactSynonym "oxoacid", "oxoacids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxacids", "oxiacids", "oxo acid", "oxy-acids", "oxyacids" ; oboInOwl:id "CHEBI:24833" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxoacid" ; rdfs:subClassOf obo:CHEBI_24651, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_39141 ] . obo:CHEBI_24834 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic anions" ; oboInOwl:id "CHEBI:24834" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic anion" ; rdfs:subClassOf obo:CHEBI_22563, obo:CHEBI_36914 . obo:CHEBI_24835 obo:IAO_0000115 "A molecular entity that contains no carbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anorganische Verbindungen", "inorganic compounds", "inorganic entity", "inorganic molecular entities", "inorganics" ; oboInOwl:id "CHEBI:24835" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic molecular entity" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_24836 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic oxides" ; oboInOwl:id "CHEBI:24836" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic oxide" ; rdfs:subClassOf obo:CHEBI_24835, obo:CHEBI_25741 . obo:CHEBI_24859 obo:IAO_0000115 "Chemical element with atomic number 53." ; chebi:charge "0" ; chebi:formula "I" ; chebi:inchi "InChI=1S/I" ; chebi:inchikey "ZCYVEMRRCGMTRW-UHFFFAOYSA-N" ; chebi:mass "126.90447" ; chebi:monoisotopicmass "126.90447" ; chebi:smiles "[I]" ; oboInOwl:hasDbXref "WebElements:I" ; oboInOwl:hasExactSynonym "iodine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "53I", "I", "Iod", "J", "Jod", "iode", "iodine", "iodium", "yodo" ; oboInOwl:id "CHEBI:24859" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodine atom" ; rdfs:subClassOf obo:CHEBI_24473, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_24860 oboInOwl:hasExactSynonym "iodine molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iodine compounds", "iodine molecular entities" ; oboInOwl:id "CHEBI:24860" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodine molecular entity" ; rdfs:subClassOf obo:CHEBI_24471, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_24859 ] . obo:CHEBI_24862 obo:IAO_0000115 "An amino acid containing at least one iodo substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24862" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodoamino acid" ; rdfs:subClassOf obo:CHEBI_24470, obo:CHEBI_37142 . obo:CHEBI_24863 chebi:charge "0" ; chebi:formula "C6H5IO" ; chebi:mass "220.008" ; chebi:monoisotopicmass "219.93851" ; oboInOwl:hasExactSynonym "iodophenol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:24863" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodophenol" ; rdfs:subClassOf obo:CHEBI_37142, obo:CHEBI_38856 . obo:CHEBI_24864 obo:IAO_0000115 "An iodoamino acid in which the amino acid specified is thyronine." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iodothyronines" ; oboInOwl:id "CHEBI:24864" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodothyronine" ; rdfs:subClassOf obo:CHEBI_24862, obo:CHEBI_33853, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30661 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63477 ] . obo:CHEBI_24866 obo:IAO_0000115 "A salt is an assembly of cations and anions." ; oboInOwl:hasExactSynonym "salt" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Salz", "Salze", "ionic compound", "ionic compounds", "sal", "sales", "salts", "sel", "sels" ; oboInOwl:id "CHEBI:24866" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "salt" ; rdfs:subClassOf obo:CHEBI_37577, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_22563 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_36916 ] . obo:CHEBI_24867 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic ions" ; oboInOwl:id "CHEBI:24867" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic ion" ; rdfs:subClassOf obo:CHEBI_24870, obo:CHEBI_33238 . obo:CHEBI_24868 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic salts", "organisches Salz" ; oboInOwl:id "CHEBI:24868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic salt" ; rdfs:subClassOf obo:CHEBI_24866 . obo:CHEBI_24870 obo:IAO_0000115 "A molecular entity having a net electric charge." ; oboInOwl:hasExactSynonym "Ion", "ion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Ionen", "iones", "ions" ; oboInOwl:id "CHEBI:24870" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ion" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_24873 oboInOwl:hasExactSynonym "iron molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iron compounds", "iron molecular entities" ; oboInOwl:id "CHEBI:24873" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron molecular entity" ; rdfs:subClassOf obo:CHEBI_33744, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_18248 ] . obo:CHEBI_24875 chebi:formula "Fe" ; chebi:mass "55.845" ; chebi:monoisotopicmass "55.93494" ; oboInOwl:hasExactSynonym "iron cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Fe cation", "iron cations" ; oboInOwl:id "CHEBI:24875" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron cation" ; rdfs:subClassOf obo:CHEBI_33515, obo:CHEBI_82663, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ] . obo:CHEBI_24898 obo:IAO_0000115 "A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration." ; chebi:charge "0" ; chebi:formula "C6H13NO2" ; chebi:mass "131.175" ; chebi:monoisotopicmass "131.09463" ; oboInOwl:hasDbXref "Beilstein:1721790", "CAS:443-79-8", "PMID:17190852", "Reaxys:1721790" ; oboInOwl:hasExactSynonym "isoleucine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hile", "rel-(2R,3R)-2-amino-3-methylpentanoic acid" ; oboInOwl:id "CHEBI:24898" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isoleucine" ; rdfs:subClassOf obo:CHEBI_38264, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_45557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32612 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32613 ] . obo:CHEBI_24913 obo:IAO_0000115 "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMPR01", "PMID:12769708", "PMID:19219049" ; oboInOwl:hasExactSynonym "isoprenoid", "isoprenoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "isoprenoids" ; oboInOwl:id "CHEBI:24913" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isoprenoid" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_50860 . obo:CHEBI_24961 oboInOwl:hasExactSynonym "ketoaldonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ketoaldonates" ; oboInOwl:id "CHEBI:24961" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ketoaldonate" ; rdfs:subClassOf obo:CHEBI_33721 . obo:CHEBI_24963 obo:IAO_0000115 "Oxo carboxylic acids formally derived from aldonic acids by replacement of a secondary CHOH group by a carbonyl group." ; oboInOwl:hasExactSynonym "ketoaldonic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ketoaldonic acids" ; oboInOwl:id "CHEBI:24963" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ketoaldonic acid" ; rdfs:subClassOf obo:CHEBI_33720, obo:CHEBI_35381 . obo:CHEBI_24995 obo:IAO_0000115 "Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." ; oboInOwl:hasExactSynonym "lactam", "lactams" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Laktam", "Laktame", "lactams" ; oboInOwl:id "CHEBI:24995" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lactam" ; rdfs:subClassOf obo:CHEBI_23443, obo:CHEBI_37622, obo:CHEBI_38101 . obo:CHEBI_24996 obo:IAO_0000115 "A hydroxy monocarboxylic acid anion that is the conjugate base of lactic acid, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H5O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1" ; chebi:inchikey "JVTAAEKCZFNVCJ-UHFFFAOYSA-M" ; chebi:mass "89.07000" ; chebi:monoisotopicmass "89.02442" ; chebi:smiles "CC(O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3587719", "CAS:113-21-3", "Gmelin:240074", "KEGG:C01432", "MetaCyc:Lactate" ; oboInOwl:hasExactSynonym "2-hydroxypropanoate", "lactate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxypropanoic acid, ion(1-)", "2-hydroxypropionate", "MeCH(OH)CO2 anion", "b-lactate", "beta-lactate" ; oboInOwl:id "CHEBI:24996" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lactate" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17272 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28358 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_78320 ] . obo:CHEBI_25017 obo:IAO_0000115 "A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group." ; chebi:charge "0" ; chebi:formula "C6H13NO2" ; chebi:inchi "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)" ; chebi:inchikey "ROHFNLRQFUQHCH-UHFFFAOYSA-N" ; chebi:mass "131.17296" ; chebi:monoisotopicmass "131.09463" ; chebi:smiles "CC(C)CC(N)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:636005", "CAS:328-39-2", "Gmelin:50203", "KEGG:C16439", "LIPID_MAPS_instance:LMFA01100048", "PMID:17439666", "Reaxys:636005", "Wikipedia:Leucine" ; oboInOwl:hasExactSynonym "leucine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+-)-Leucine", "(RS)-Leucine", "2-amino-4-methylpentanoic acid", "DL-Leucine", "Hleu", "L", "Leu", "Leucin", "Leuzin" ; oboInOwl:id "CHEBI:25017" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "leucine" ; rdfs:subClassOf obo:CHEBI_22918, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_30356 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32627 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32628 ] . obo:CHEBI_25046 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25046" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "linear tetrapyrrole" ; rdfs:subClassOf obo:CHEBI_26932 . obo:CHEBI_25094 obo:IAO_0000115 "A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6." ; chebi:charge "0" ; chebi:formula "C6H14N2O2" ; chebi:inchi "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)" ; chebi:inchikey "KDXKERNSBIXSRK-UHFFFAOYSA-N" ; chebi:mass "146.18764" ; chebi:monoisotopicmass "146.10553" ; chebi:smiles "NCCCCC(N)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:1616991", "CAS:70-54-2", "Gmelin:279284", "KEGG:C16440", "PMID:17439666", "PMID:22264337", "Reaxys:1616991", "Wikipedia:Lysine" ; oboInOwl:hasExactSynonym "2,6-diaminohexanoic acid", "lysine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "K", "LYS", "Lysin", "alpha,epsilon-diaminocaproic acid" ; oboInOwl:id "CHEBI:25094" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lysine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_35987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50339 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30776 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32563 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32564 ] . obo:CHEBI_25107 chebi:charge "0" ; chebi:formula "Mg" ; chebi:inchi "InChI=1S/Mg" ; chebi:inchikey "FYYHWMGAXLPEAU-UHFFFAOYSA-N" ; chebi:mass "24.30500" ; chebi:monoisotopicmass "23.98504" ; chebi:smiles "[Mg]" ; oboInOwl:hasDbXref "CAS:7439-95-4", "DrugBank:DB01378", "Gmelin:16207", "KEGG:C00305", "WebElements:Mg" ; oboInOwl:hasExactSynonym "magnesium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "12Mg", "Magnesium", "Mg", "magnesio", "magnesium" ; oboInOwl:id "CHEBI:25107" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "magnesium atom" ; rdfs:subClassOf obo:CHEBI_22313, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_25147 chebi:charge "-1" ; chebi:formula "C8H7O3" ; chebi:inchi "InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/p-1" ; chebi:inchikey "IWYDHOAUDWTVEP-UHFFFAOYSA-M" ; chebi:mass "151.13938" ; chebi:monoisotopicmass "151.04007" ; chebi:smiles "OC(C([O-])=O)c1ccccc1" ; oboInOwl:hasDbXref "Beilstein:3905858", "Beilstein:4135334", "CAS:769-61-9", "Gmelin:328159" ; oboInOwl:hasExactSynonym "hydroxy(phenyl)acetate", "mandelate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxy-2-(4-hydroxyphenyl)acetate", "alpha-hydroxybenzeneacetate", "alpha-hydroxybenzeneacetic acid, ion(1-)", "mandelate ion" ; oboInOwl:id "CHEBI:25147" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mandelate" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30089 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35825 ] . obo:CHEBI_25212 obo:IAO_0000115 "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." ; oboInOwl:hasAlternativeId "CHEBI:26619", "CHEBI:35220" ; oboInOwl:hasExactSynonym "metabolite" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "metabolites", "primary metabolites", "secondary metabolites" ; oboInOwl:id "CHEBI:25212" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metabolite" ; rdfs:subClassOf obo:CHEBI_52206 . obo:CHEBI_25213 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a metal cation", "metal cations" ; oboInOwl:id "CHEBI:25213" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metal cation" ; rdfs:subClassOf obo:CHEBI_23906, obo:CHEBI_36915 . obo:CHEBI_25216 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "metalloporphyrins", "metaloporphyrins" ; oboInOwl:id "CHEBI:25216" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metalloporphyrin" ; rdfs:subClassOf obo:CHEBI_26214, obo:CHEBI_33240, obo:CHEBI_33909 . obo:CHEBI_25235 obo:IAO_0000115 "Compounds containing a benzene skeleton substituted with one methoxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monomethoxybenzenes" ; oboInOwl:id "CHEBI:25235" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monomethoxybenzene" ; rdfs:subClassOf obo:CHEBI_51683 . obo:CHEBI_25274 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methylated amines" ; oboInOwl:id "CHEBI:25274" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylamines" ; rdfs:subClassOf obo:CHEBI_22331 . obo:CHEBI_25345 obo:IAO_0000115 "A group of heterocyclic compounds based on the N-methylated 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methyltetrahydrofolates" ; oboInOwl:id "CHEBI:25345" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methyltetrahydrofolate" ; rdfs:subClassOf obo:CHEBI_67016 . obo:CHEBI_25354 obo:IAO_0000115 "Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mineralocorticoids" ; oboInOwl:id "CHEBI:25354" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mineralocorticoid" ; rdfs:subClassOf obo:CHEBI_36699 . obo:CHEBI_25355 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mitochondrial electron transport chain inhibitors", "mitochondrial electron-transport chain inhibitor", "mitochondrial respiratory chain inhibitors" ; oboInOwl:id "CHEBI:25355" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mitochondrial respiratory-chain inhibitor" ; rdfs:subClassOf obo:CHEBI_38497 . obo:CHEBI_25362 obo:IAO_0000115 "A molecule all atoms of which have the same atomic number." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "homoatomic molecule", "homoatomic molecules" ; oboInOwl:id "CHEBI:25362" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental molecule" ; rdfs:subClassOf obo:CHEBI_25367, obo:CHEBI_33259 . obo:CHEBI_25367 obo:IAO_0000115 "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." ; oboInOwl:hasExactSynonym "molecule" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Molekuel", "molecula", "molecules", "neutral molecular compounds" ; oboInOwl:id "CHEBI:25367" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "molecule" ; rdfs:subClassOf obo:CHEBI_36357 . obo:CHEBI_25375 obo:IAO_0000115 "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monamines", "monoamines" ; oboInOwl:id "CHEBI:25375" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoamine molecular messenger" ; rdfs:subClassOf obo:CHEBI_63534, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33280 ] . obo:CHEBI_25384 obo:IAO_0000115 "An oxoacid containing a single carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocarboxylic acids" ; oboInOwl:id "CHEBI:25384" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35757 ] . obo:CHEBI_25414 chebi:charge "+1" ; chebi:mass "0.00000" ; chebi:smiles "[*+]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic monocations", "monovalent inorganic cations" ; oboInOwl:id "CHEBI:25414" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic monocation" ; rdfs:subClassOf obo:CHEBI_23906 . obo:CHEBI_25481 obo:IAO_0000115 "A polycyclic aromatic ketone metabolite of naphthalene." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "naphthoquinones" ; oboInOwl:id "CHEBI:25481" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "naphthoquinone" ; rdfs:subClassOf obo:CHEBI_36141 . obo:CHEBI_25500 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25500" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neopterins" ; rdfs:subClassOf obo:CHEBI_26375 . obo:CHEBI_25506 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25506" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neuraminates" ; rdfs:subClassOf obo:CHEBI_63561, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25508 ] . obo:CHEBI_25508 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25508" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neuraminic acids" ; rdfs:subClassOf obo:CHEBI_28963, obo:CHEBI_63394, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_25506 ] . obo:CHEBI_25512 obo:IAO_0000115 "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." ; oboInOwl:hasDbXref "Wikipedia:Neurotransmitter" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "neurotransmitters" ; oboInOwl:id "CHEBI:25512" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neurotransmitter" ; rdfs:subClassOf obo:CHEBI_33280 . obo:CHEBI_25513 obo:IAO_0000115 "Any glycosphingolipid containing unsubstituted glycosyl moieties." ; oboInOwl:hasAlternativeId "CHEBI:7543" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "neutral glycosphingolipids" ; oboInOwl:id "CHEBI:25513" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neutral glycosphingolipid" ; rdfs:subClassOf obo:CHEBI_24402 . obo:CHEBI_25555 chebi:charge "0" ; chebi:formula "N" ; chebi:mass "14.007" ; chebi:monoisotopicmass "14.00307" ; oboInOwl:hasDbXref "WebElements:N" ; oboInOwl:hasExactSynonym "nitrogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "7N", "N", "Stickstoff", "azote", "nitrogen", "nitrogeno" ; oboInOwl:id "CHEBI:25555" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nitrogen atom" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33300, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_25585 oboInOwl:hasExactSynonym "nonmetal" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Nichtmetall", "Nichtmetalle", "no metal", "no metales", "non-metal", "non-metaux", "nonmetal", "nonmetals" ; oboInOwl:id "CHEBI:25585" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nonmetal atom" ; rdfs:subClassOf obo:CHEBI_33250 . obo:CHEBI_25629 obo:IAO_0000115 "A fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid). Stearates have a variety of uses in the pharmaceutical industry." ; chebi:charge "-1" ; chebi:formula "C18H35O2" ; chebi:inchi "InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1" ; chebi:inchikey "QIQXTHQIDYTFRH-UHFFFAOYSA-M" ; chebi:mass "283.470" ; chebi:monoisotopicmass "283.26425" ; chebi:smiles "C(CCCCCCCCCC)CCCCCCC(=O)[O-]" ; oboInOwl:hasAlternativeId "CHEBI:231588" ; oboInOwl:hasDbXref "Beilstein:3590530", "CAS:646-29-7", "Gmelin:344065", "KEGG:C01530", "MetaCyc:STEARIC_ACID", "PMID:16401590", "PMID:19184617", "PMID:3180776", "PMID:7452460", "Reaxys:3590530" ; oboInOwl:hasExactSynonym "octadecanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-[CH2]16-COO(-)", "Stearate", "octadecanoic acid, ion(1-)", "stearate", "stearic acid, ion(1-)" ; oboInOwl:id "CHEBI:25629" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "octadecanoate" ; rdfs:subClassOf obo:CHEBI_57560, obo:CHEBI_58954, obo:CHEBI_78125, obo:CHEBI_83955, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28842 ] . obo:CHEBI_25676 obo:IAO_0000115 "A peptide containing a relatively small number of amino acids." ; oboInOwl:hasAlternativeId "CHEBI:7755" ; oboInOwl:hasDbXref "Wikipedia:Oligopeptide" ; oboInOwl:hasExactSynonym "oligopeptides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Oligopeptid", "oligopeptido" ; oboInOwl:id "CHEBI:25676" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oligopeptide" ; rdfs:subClassOf obo:CHEBI_16670 . obo:CHEBI_25693 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic heteromonocyclic compounds" ; oboInOwl:id "CHEBI:25693" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic heteromonocyclic compound" ; rdfs:subClassOf obo:CHEBI_24532, obo:CHEBI_33670 . obo:CHEBI_25696 obo:IAO_0000115 "Any organic ion with a net negative charge." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic anions" ; oboInOwl:id "CHEBI:25696" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic anion" ; rdfs:subClassOf obo:CHEBI_22563, obo:CHEBI_25699 . obo:CHEBI_25697 obo:IAO_0000115 "Any organic ion with a net positive charge." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic cations" ; oboInOwl:id "CHEBI:25697" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic cation" ; rdfs:subClassOf obo:CHEBI_25699, obo:CHEBI_36916 . obo:CHEBI_25698 obo:IAO_0000115 "An organooxygen compound with formula ROR, where R is not hydrogen." ; chebi:charge "0" ; chebi:formula "OR2" ; chebi:mass "15.99940" ; chebi:monoisotopicmass "15.99491" ; chebi:smiles "[*]O[*]" ; oboInOwl:hasExactSynonym "ether", "ethers" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ethers" ; oboInOwl:id "CHEBI:25698" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ether" ; rdfs:subClassOf obo:CHEBI_36963 . obo:CHEBI_25699 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic ions" ; oboInOwl:id "CHEBI:25699" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic ion" ; rdfs:subClassOf obo:CHEBI_24870, obo:CHEBI_50860 . obo:CHEBI_25701 obo:IAO_0000115 "An oxide in which the oxygen atom is bonded to a carbon atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic oxides" ; oboInOwl:id "CHEBI:25701" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic oxide" ; rdfs:subClassOf obo:CHEBI_25741, obo:CHEBI_72695 . obo:CHEBI_25703 oboInOwl:hasDbXref "Wikipedia:Organophosphate" ; oboInOwl:hasExactSynonym "organic phosphate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic phosphate ester", "organic phosphate esters", "organic phosphates", "organophosphate ester", "organophosphate esters" ; oboInOwl:id "CHEBI:25703" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic phosphate" ; rdfs:subClassOf obo:CHEBI_25710, obo:CHEBI_26020, obo:CHEBI_26079 . obo:CHEBI_25704 obo:IAO_0000115 "Compounds of the general formula SO3HOR where R is an organyl group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic sulfates" ; oboInOwl:id "CHEBI:25704" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic sulfate" ; rdfs:subClassOf obo:CHEBI_26820, obo:CHEBI_37826, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58958 ] . obo:CHEBI_2571 obo:IAO_0000115 "An alcohol derived from an aliphatic compound." ; chebi:charge "0" ; chebi:formula "HOR" ; chebi:mass "17.007" ; chebi:monoisotopicmass "17.00274" ; chebi:smiles "O*" ; oboInOwl:hasDbXref "KEGG:C02525" ; oboInOwl:hasExactSynonym "Aliphatic alcohol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aliphatic alcohols", "an aliphatic alcohol" ; oboInOwl:id "CHEBI:2571" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aliphatic alcohol" ; rdfs:subClassOf obo:CHEBI_30879 . obo:CHEBI_25710 obo:IAO_0000115 "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." ; oboInOwl:hasDbXref "Wikipedia:Organophosphorus_compound" ; oboInOwl:hasExactSynonym "organophosphorus compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organophosphorus compounds" ; oboInOwl:id "CHEBI:25710" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organophosphorus compound" ; rdfs:subClassOf obo:CHEBI_26082, obo:CHEBI_33285 . obo:CHEBI_25728 obo:IAO_0000115 "A solute used by a cell under water stress to maintain cell volume." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "osmolytes" ; oboInOwl:id "CHEBI:25728" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "osmolyte" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_25741 obo:IAO_0000115 "An oxide is a chemical compound of oxygen with other chemical elements." ; oboInOwl:hasExactSynonym "oxide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxides" ; oboInOwl:id "CHEBI:25741" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxide" ; rdfs:subClassOf obo:CHEBI_25806, obo:CHEBI_37577 . obo:CHEBI_25754 obo:IAO_0000115 "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." ; oboInOwl:hasExactSynonym "oxo carboxylic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo acids", "oxo carboxylic acids" ; oboInOwl:id "CHEBI:25754" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo carboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35903 ] . obo:CHEBI_25798 obo:IAO_0000115 "The conjugate base of any oxopentanoic acid." ; chebi:charge "0" ; chebi:formula "C5H7O3" ; chebi:mass "115.107" ; chebi:monoisotopicmass "115.03952" ; oboInOwl:hasExactSynonym "oxopentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25798" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxopentanoates" ; rdfs:subClassOf obo:CHEBI_35902, obo:CHEBI_59836, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_31011 ] . obo:CHEBI_25799 obo:IAO_0000115 "A C5 fatty acid carrying an oxo group at any position." ; chebi:charge "0" ; chebi:formula "C5H8O3" ; chebi:mass "116.115" ; chebi:monoisotopicmass "116.04734" ; oboInOwl:hasExactSynonym "oxopentanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxovaleric acid" ; oboInOwl:id "CHEBI:25799" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxopentanoic acid" ; rdfs:subClassOf obo:CHEBI_59644, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17418 ] . obo:CHEBI_2580 obo:IAO_0000115 "Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:2580" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "unsaturated fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27208 ] . obo:CHEBI_25801 obo:IAO_0000115 "A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent." ; chebi:charge "0" ; chebi:formula "C5H7NO3" ; chebi:mass "129.114" ; chebi:monoisotopicmass "129.04259" ; oboInOwl:hasExactSynonym "oxoproline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25801" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxoproline" ; rdfs:subClassOf obo:CHEBI_26273, obo:CHEBI_38275, obo:CHEBI_46701 . obo:CHEBI_25805 chebi:charge "0" ; chebi:formula "O" ; chebi:inchi "InChI=1S/O" ; chebi:inchikey "QVGXLLKOCUKJST-UHFFFAOYSA-N" ; chebi:mass "15.99940" ; chebi:monoisotopicmass "15.99491" ; chebi:smiles "[O]" ; oboInOwl:hasDbXref "KEGG:C00007", "WebElements:O" ; oboInOwl:hasExactSynonym "oxygen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "8O", "O", "Sauerstoff", "oxigeno", "oxygen", "oxygene" ; oboInOwl:id "CHEBI:25805" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxygen atom" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33303, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_25806 oboInOwl:hasExactSynonym "oxygen molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxygen molecular entities" ; oboInOwl:id "CHEBI:25806" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxygen molecular entity" ; rdfs:subClassOf obo:CHEBI_33304, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_25805 ] . obo:CHEBI_25810 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxopurines" ; oboInOwl:id "CHEBI:25810" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxopurine" ; rdfs:subClassOf obo:CHEBI_26401 . obo:CHEBI_25830 obo:IAO_0000115 "A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "p-quinone", "para-quinones" ; oboInOwl:id "CHEBI:25830" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "p-quinones" ; rdfs:subClassOf obo:CHEBI_36141 . obo:CHEBI_25899 obo:IAO_0000115 "An alditol obtained by reduction of any pentose." ; oboInOwl:hasExactSynonym "pentitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pentitols" ; oboInOwl:id "CHEBI:25899" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pentitol" ; rdfs:subClassOf obo:CHEBI_17522 . obo:CHEBI_25901 obo:IAO_0000115 "A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose)." ; oboInOwl:hasExactSynonym "pentose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pentoses" ; oboInOwl:id "CHEBI:25901" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pentose" ; rdfs:subClassOf obo:CHEBI_35381 . obo:CHEBI_25905 obo:IAO_0000115 "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "peptide hormones", "polypeptide hormone" ; oboInOwl:id "CHEBI:25905" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "peptide hormone" ; rdfs:subClassOf obo:CHEBI_16670, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] . obo:CHEBI_25978 obo:IAO_0000115 "Any monocarboxylic acid that is phenylacetic acid or its substituted derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25978" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylacetic acids" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_25384 . obo:CHEBI_25985 obo:IAO_0000115 "An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine by a heteroatom. The definition normally excludes peptides containing phenylalanine residues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:25985" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylalanine derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_28044 ] . obo:CHEBI_26020 obo:IAO_0000115 "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." ; oboInOwl:hasExactSynonym "phosphates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "phosphates" ; oboInOwl:id "CHEBI:26020" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphate" ; rdfs:subClassOf obo:CHEBI_26079 . obo:CHEBI_26078 obo:IAO_0000115 "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." ; chebi:charge "0" ; chebi:formula "H3O4P" ; chebi:inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)" ; chebi:inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-N" ; chebi:mass "97.99520" ; chebi:monoisotopicmass "97.97690" ; chebi:smiles "[H]OP(=O)(O[H])O[H]" ; oboInOwl:hasDbXref "Beilstein:1921286", "CAS:7664-38-2", "Drug_Central:4478", "Gmelin:2000", "HMDB:HMDB0002142", "KEGG:C00009", "KEGG:D05467", "KNApSAcK:C00007408", "PMID:11455380", "PMID:15630224", "PMID:17439666", "PMID:17518491", "PMID:22282755", "PMID:22333268", "PMID:22381614", "PMID:22401268", "Reaxys:1921286", "Wikipedia:Phosphoric_Acid" ; oboInOwl:hasExactSynonym "Phosphoric acid", "phosphoric acid", "tetraoxophosphoric acid", "trihydrogen tetraoxophosphate(3-)", "trihydroxidooxidophosphorus" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H3PO4", "Orthophosphoric acid", "Phosphate", "Phosphorsaeure", "Phosphorsaeureloesungen", "[PO(OH)3]", "acide phosphorique", "acidum phosphoricum", "orthophosphoric acid" ; oboInOwl:id "CHEBI:26078" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphoric acid" ; rdfs:subClassOf obo:CHEBI_59698, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33287 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_46787 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35780 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_39745 ] . obo:CHEBI_26079 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26079" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "phosphoric acid derivative" ; rdfs:subClassOf obo:CHEBI_36359, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_26078 ] . obo:CHEBI_26082 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "phosphorus molecular entities" ; oboInOwl:id "CHEBI:26082" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphorus molecular entity" ; rdfs:subClassOf obo:CHEBI_33302, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_28659 ] . obo:CHEBI_26130 obo:IAO_0000115 "An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pigments" ; oboInOwl:id "CHEBI:26130" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biological pigment" ; rdfs:subClassOf obo:CHEBI_52208 . obo:CHEBI_26155 obo:IAO_0000115 "A chemical, natural or artificial, that can affect the rate of growth of a plant." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "plant growth regulators" ; oboInOwl:id "CHEBI:26155" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "plant growth regulator" ; rdfs:subClassOf obo:CHEBI_39317 . obo:CHEBI_26167 obo:IAO_0000115 "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "OC(C(*)N)=O" ; oboInOwl:hasAlternativeId "CHEBI:8283" ; oboInOwl:hasDbXref "MetaCyc:Polar-amino-acids", "PMID:12016058" ; oboInOwl:hasExactSynonym "polar amino acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polar amino acids", "polar amino-acid", "polar amino-acids" ; oboInOwl:id "CHEBI:26167" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polar amino acid" ; rdfs:subClassOf obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_62031 ] . obo:CHEBI_26191 obo:IAO_0000115 "A compound that contains two or more hydroxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyols" ; oboInOwl:id "CHEBI:26191" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyol" ; rdfs:subClassOf obo:CHEBI_33822 . obo:CHEBI_26214 obo:IAO_0000115 "Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure." ; oboInOwl:hasDbXref "Wikipedia:Porphyrin" ; oboInOwl:hasExactSynonym "porphyrins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26214" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "porphyrins" ; rdfs:subClassOf obo:CHEBI_36309, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ] . obo:CHEBI_26216 chebi:charge "0" ; chebi:formula "K" ; chebi:inchi "InChI=1S/K" ; chebi:inchikey "ZLMJMSJWJFRBEC-UHFFFAOYSA-N" ; chebi:mass "39.09830" ; chebi:monoisotopicmass "38.96371" ; chebi:smiles "[K]" ; oboInOwl:hasDbXref "CAS:7440-09-7", "DrugBank:DB01345", "KEGG:C00238", "WebElements:K" ; oboInOwl:hasExactSynonym "potassium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "19K", "K", "Kalium", "kalium", "potasio", "potassium" ; oboInOwl:id "CHEBI:26216" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "potassium atom" ; rdfs:subClassOf obo:CHEBI_22314, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ] . obo:CHEBI_26217 oboInOwl:hasExactSynonym "potassium molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "potassium molecular entities" ; oboInOwl:id "CHEBI:26217" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "potassium molecular entity" ; rdfs:subClassOf obo:CHEBI_33296, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_26216 ] . obo:CHEBI_26271 obo:IAO_0000115 "An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2." ; chebi:charge "0" ; chebi:formula "C5H9NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)" ; chebi:inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-N" ; chebi:mass "115.13050" ; chebi:monoisotopicmass "115.06333" ; chebi:smiles "OC(=O)C1CCCN1" ; oboInOwl:hasDbXref "Beilstein:80809", "CAS:609-36-9", "Gmelin:26927", "KEGG:C16435", "PMID:16534801", "PMID:21400017", "PMID:21903295", "PMID:22264337", "PMID:22280966", "PMID:22770225", "Reaxys:80809", "Wikipedia:Proline" ; oboInOwl:hasExactSynonym "proline" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DL-Proline", "Hpro", "Prolin", "prolina", "pyrrolidine-2-carboxylic acid" ; oboInOwl:id "CHEBI:26271" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proline" ; rdfs:subClassOf obo:CHEBI_33704, obo:CHEBI_38260, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32871 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32872 ] . obo:CHEBI_26273 obo:IAO_0000115 "An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "proline derivatives" ; oboInOwl:id "CHEBI:26273" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proline derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_26271 ] . obo:CHEBI_26284 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26284" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "propane-1,2-diols" ; rdfs:subClassOf obo:CHEBI_26288 . obo:CHEBI_26288 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26288" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "propanediol" ; rdfs:subClassOf obo:CHEBI_13643 . obo:CHEBI_26333 obo:IAO_0000115 "Naturally occurring compounds derived from the parent C20 acid, prostanoic acid." ; oboInOwl:hasDbXref "CAS:11000-26-3", "LIPID_MAPS_class:LMFA0301" ; oboInOwl:hasExactSynonym "prostaglandin", "prostaglandins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prostaglandins" ; oboInOwl:id "CHEBI:26333" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostaglandin" ; rdfs:subClassOf obo:CHEBI_26347, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_8504 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59326 ] . obo:CHEBI_26338 chebi:charge "0" ; chebi:formula "C5H6O2R2" ; chebi:mass "98.09990" ; chebi:monoisotopicmass "98.03678" ; chebi:smiles "O[C@@H]1CC(=O)[C@H]([*])[C@H]1[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "PGE" ; oboInOwl:id "CHEBI:26338" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostaglandins E" ; rdfs:subClassOf obo:CHEBI_26333, obo:CHEBI_35681, obo:CHEBI_3992 . obo:CHEBI_26347 obo:IAO_0000115 "The family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes." ; oboInOwl:hasExactSynonym "prostanoid", "prostanoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prostanoids" ; oboInOwl:id "CHEBI:26347" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostanoid" ; rdfs:subClassOf obo:CHEBI_23899, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62943 ] . obo:CHEBI_26348 obo:IAO_0000115 "A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity." ; oboInOwl:hasExactSynonym "prosthetic group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "groupe prosthetique", "prosthetic groups" ; oboInOwl:id "CHEBI:26348" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prosthetic group" ; rdfs:subClassOf obo:CHEBI_23357 . obo:CHEBI_26361 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26361" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "protoporphyrins" ; rdfs:subClassOf obo:CHEBI_26214 . obo:CHEBI_26373 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26373" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pteridines" ; rdfs:subClassOf obo:CHEBI_27171, obo:CHEBI_33833, obo:CHEBI_38101 . obo:CHEBI_26375 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26375" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pterins" ; rdfs:subClassOf obo:CHEBI_26373 . obo:CHEBI_26386 obo:IAO_0000115 "A nucleobase whose skeleton is derived from purine." ; chebi:charge "0" ; chebi:formula "C5H3N4R2" ; chebi:mass "119.104" ; chebi:monoisotopicmass "119.03577" ; chebi:smiles "C1(NC(=NC=2NC=NC12)*)=*" ; oboInOwl:hasDbXref "KEGG:C15587" ; oboInOwl:hasExactSynonym "purine nucleobase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a purine nucleobase", "purine bases", "purine nucleobases" ; oboInOwl:id "CHEBI:26386" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "purine nucleobase" ; rdfs:subClassOf obo:CHEBI_18282, obo:CHEBI_26401 . obo:CHEBI_26401 obo:IAO_0000115 "A class of imidazopyrimidines that consists of purine and its substituted derivatives." ; chebi:charge "0" ; chebi:formula "C5N4R7" ; chebi:mass "116.080" ; chebi:monoisotopicmass "116.01230" ; oboInOwl:hasAlternativeId "CHEBI:13678" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26401" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "purines" ; rdfs:subClassOf obo:CHEBI_35875 . obo:CHEBI_26421 obo:IAO_0000115 "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26421" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyridines" ; rdfs:subClassOf obo:CHEBI_25693, obo:CHEBI_38101 . obo:CHEBI_26432 obo:IAO_0000115 "A nucleobase whose skeleton is derived from pyrimidine." ; chebi:charge "0" ; chebi:formula "C4HN2R4" ; chebi:mass "77.064" ; chebi:monoisotopicmass "77.01397" ; chebi:smiles "N1C(=C(C(=NC1=*)*)*)*" ; oboInOwl:hasExactSynonym "pyrimidine nucleobase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a pyrimidine nucleobase", "pyrimidine bases", "pyrimidine nucleobases" ; oboInOwl:id "CHEBI:26432" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidine nucleobase" ; rdfs:subClassOf obo:CHEBI_18282, obo:CHEBI_39447 . obo:CHEBI_26447 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrimidinemonocarboxylic acids" ; oboInOwl:id "CHEBI:26447" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidinemonocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_78574 . obo:CHEBI_26455 obo:IAO_0000115 "An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26455" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrroles" ; rdfs:subClassOf obo:CHEBI_68452 . obo:CHEBI_26456 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrrolidine alkaloids" ; oboInOwl:id "CHEBI:26456" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidine alkaloid" ; rdfs:subClassOf obo:CHEBI_22315, obo:CHEBI_38260 . obo:CHEBI_26463 obo:IAO_0000115 "An L-alpha-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyruvate family amino acids" ; oboInOwl:id "CHEBI:26463" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyruvate family amino acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_83813 . obo:CHEBI_26469 obo:IAO_0000115 "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:26469" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "quaternary nitrogen compound" ; rdfs:subClassOf obo:CHEBI_35352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_35267 ] . obo:CHEBI_26537 obo:IAO_0000115 "Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof." ; oboInOwl:hasExactSynonym "retinoid", "retinoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "retinoids" ; oboInOwl:id "CHEBI:26537" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "retinoid" ; rdfs:subClassOf obo:CHEBI_23849, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_139589 ] . obo:CHEBI_26607 obo:IAO_0000115 "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." ; oboInOwl:hasDbXref "PMID:16492686", "PMID:19763019", "PMID:20237329" ; oboInOwl:hasExactSynonym "saturated fatty acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "SFA", "SFAs", "saturated fatty acids" ; oboInOwl:id "CHEBI:26607" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "saturated fatty acid" ; rdfs:subClassOf obo:CHEBI_35366 . obo:CHEBI_26650 obo:IAO_0000115 "An L-alpha-amino acid which is biosynthesised from 3-phosphoglycerate (i.e. serine, glycine, cysteine and homocysteine). A closed class." ; oboInOwl:hasDbXref "PMID:20709681" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-phosphoglycerate family amino acid", "3-phosphoglycerate family amino acids", "serine family amino acids" ; oboInOwl:id "CHEBI:26650" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serine family amino acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_83813 . obo:CHEBI_26666 obo:IAO_0000115 "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." ; chebi:charge "0" ; chebi:formula "CH2OR" ; chebi:mass "45.017" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "OC([*])=O" ; oboInOwl:hasDbXref "PMID:16633129", "PMID:16870803", "PMID:18203540", "PMID:20148677" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "SCFA", "SCFAs", "short-chain fatty acids" ; oboInOwl:id "CHEBI:26666" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "short-chain fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58951 ] . obo:CHEBI_26667 obo:IAO_0000115 "Any of the N-acylneuraminic acids and their esters and other derivatives of the alcoholic hydroxy groups." ; oboInOwl:hasDbXref "Wikipedia:Sialic_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Sialsaeure", "Sialsaeuren", "acide sialique", "acides sialique", "sialic acids" ; oboInOwl:id "CHEBI:26667" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sialic acid" ; rdfs:subClassOf obo:CHEBI_25508, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62944 ] . obo:CHEBI_26708 chebi:charge "0" ; chebi:formula "Na" ; chebi:inchi "InChI=1S/Na" ; chebi:inchikey "KEAYESYHFKHZAL-UHFFFAOYSA-N" ; chebi:mass "22.98977" ; chebi:monoisotopicmass "22.98977" ; chebi:smiles "[Na]" ; oboInOwl:hasDbXref "CAS:7440-23-5", "Gmelin:16221", "KEGG:C01330", "WebElements:Na" ; oboInOwl:hasExactSynonym "sodium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "11Na", "Na", "Natrium", "natrium", "sodio", "sodium" ; oboInOwl:id "CHEBI:26708" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sodium atom" ; rdfs:subClassOf obo:CHEBI_22314, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ] . obo:CHEBI_26712 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sodium compounds", "sodium molecular entities" ; oboInOwl:id "CHEBI:26712" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sodium molecular entity" ; rdfs:subClassOf obo:CHEBI_33296, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_26708 ] . obo:CHEBI_26714 obo:IAO_0000115 "Any alkali metal salt having sodium(1+) as the cation." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Natriumsalz", "Natriumsalze", "sodium salts" ; oboInOwl:id "CHEBI:26714" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sodium salt" ; rdfs:subClassOf obo:CHEBI_26712, obo:CHEBI_35479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_29101 ] . obo:CHEBI_26739 obo:IAO_0000115 "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sphingolipids" ; oboInOwl:id "CHEBI:26739" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sphingolipid" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_35352, obo:CHEBI_36963 . obo:CHEBI_26764 obo:IAO_0000115 "Any steroid that acts as hormone." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Steroidhormon", "Steroidhormone", "hormona esteroide", "hormonas esteroideas", "hormone steroide", "hormones steroides", "steroid hormones" ; oboInOwl:id "CHEBI:26764" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid hormone" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] . obo:CHEBI_26819 obo:IAO_0000115 "An ester of an alcohol and sulfuric acid." ; chebi:charge "0" ; chebi:formula "O4SR2" ; chebi:mass "96.06300" ; chebi:monoisotopicmass "95.95173" ; chebi:smiles "[*]OS(=O)(=O)O[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfate ester", "sulfuric acid ester", "sulfuric acid esters" ; oboInOwl:id "CHEBI:26819" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfuric ester" ; rdfs:subClassOf obo:CHEBI_35701, obo:CHEBI_37826 . obo:CHEBI_26820 obo:IAO_0000115 "Salts and esters of sulfuric acid" ; oboInOwl:hasExactSynonym "sulfates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfuric acid derivative", "sulphates" ; oboInOwl:id "CHEBI:26820" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfates" ; rdfs:subClassOf obo:CHEBI_37826 . obo:CHEBI_26822 obo:IAO_0000115 "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulphides" ; oboInOwl:id "CHEBI:26822" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfide" ; rdfs:subClassOf obo:CHEBI_26835 . obo:CHEBI_26833 chebi:charge "0" ; chebi:formula "S" ; chebi:inchi "InChI=1S/S" ; chebi:inchikey "NINIDFKCEFEMDL-UHFFFAOYSA-N" ; chebi:mass "32.06600" ; chebi:monoisotopicmass "31.97207" ; chebi:smiles "[S]" ; oboInOwl:hasDbXref "CAS:7704-34-9", "KEGG:C00087", "KEGG:D06527", "PPDB:605", "WebElements:S" ; oboInOwl:hasExactSynonym "sulfur" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "16S", "Elemental sulfur", "S", "Schwefel", "azufre", "soufre", "sulfur", "sulphur", "theion" ; oboInOwl:id "CHEBI:26833" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur atom" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33303, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_26834 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfur-containing amino acids" ; oboInOwl:id "CHEBI:26834" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur-containing amino acid" ; rdfs:subClassOf obo:CHEBI_33576, obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63470 ] . obo:CHEBI_26835 oboInOwl:hasExactSynonym "sulfur molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfur molecular entities" ; oboInOwl:id "CHEBI:26835" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur molecular entity" ; rdfs:subClassOf obo:CHEBI_33304, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_26833 ] . obo:CHEBI_26836 obo:IAO_0000115 "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." ; chebi:charge "0" ; chebi:formula "H2O4S" ; chebi:inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)" ; chebi:inchikey "QAOWNCQODCNURD-UHFFFAOYSA-N" ; chebi:mass "98.07948" ; chebi:monoisotopicmass "97.96738" ; chebi:smiles "[H]OS(=O)(=O)O[H]" ; oboInOwl:hasDbXref "CAS:7664-93-9", "Gmelin:2122", "KEGG:C00059", "KEGG:D05963", "KNApSAcK:C00007530", "MolBase:4", "PMID:13568755", "PMID:16122922", "PMID:19397353", "PMID:22047659", "PMID:22136045", "PMID:22204399", "PMID:22267186", "PMID:22296037", "PMID:22364556", "PMID:22435616", "PPDB:606", "Reaxys:2037554", "Wikipedia:Sulfuric_acid" ; oboInOwl:hasExactSynonym "Sulfuric acid", "dihydrogen tetraoxosulfate", "dihydroxidodioxidosulfur", "hydrogen tetraoxosulfate(2-)", "hydrogen tetraoxosulfate(VI)", "sulfuric acid", "tetraoxosulfuric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Acide sulfurique", "Acido sulfurico", "Acidum sulfuricum", "H2SO4", "Schwefelsaeureloesungen", "[S(OH)2O2]", "[SO2(OH)2]", "sulphuric acid" ; oboInOwl:id "CHEBI:26836" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfuric acid" ; rdfs:subClassOf obo:CHEBI_33402, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35223 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_45696 ] . obo:CHEBI_26873 obo:IAO_0000115 "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." ; oboInOwl:hasDbXref "Wikipedia:Terpenoid" ; oboInOwl:hasExactSynonym "Terpenoid", "terpenoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "terpenoide", "terpenoides" ; oboInOwl:id "CHEBI:26873" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "terpenoid" ; rdfs:subClassOf obo:CHEBI_24913, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35186 ] . obo:CHEBI_26878 obo:IAO_0000115 "A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it." ; chebi:charge "0" ; chebi:formula "C4H7OR3" ; chebi:mass "71.09780" ; chebi:monoisotopicmass "71.04969" ; chebi:smiles "OC(C[*])(C[*])C[*]" ; oboInOwl:hasExactSynonym "tertiary alcohol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tertiary alcohols" ; oboInOwl:id "CHEBI:26878" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tertiary alcohol" ; rdfs:subClassOf obo:CHEBI_30879 . obo:CHEBI_26907 obo:IAO_0000115 "A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid units." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tetrahydrofolate", "tetrahydrofolates", "tetrahydrofolic acids" ; oboInOwl:id "CHEBI:26907" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetrahydrofolic acid" ; rdfs:subClassOf obo:CHEBI_37445, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_67016 ] . obo:CHEBI_26932 obo:IAO_0000115 "A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." ; oboInOwl:hasExactSynonym "tetrapyrrole", "tetrapyrroles" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a tetrapyrrole" ; oboInOwl:id "CHEBI:26932" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetrapyrrole" ; rdfs:subClassOf obo:CHEBI_33833, obo:CHEBI_38077 . obo:CHEBI_26935 obo:IAO_0000115 "Any terpenoid derived from a tetraterpene. The term includes compounds in which the C40 skeleton of the parent tetraterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMPR0107" ; oboInOwl:hasExactSynonym "tetraterpenoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C40 isoprenoids", "tetraterpenoides" ; oboInOwl:id "CHEBI:26935" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetraterpenoid" ; rdfs:subClassOf obo:CHEBI_26873, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35193 ] . obo:CHEBI_26981 chebi:charge "0" ; chebi:formula "C4H10O4" ; chebi:mass "122.120" ; chebi:monoisotopicmass "122.05791" ; oboInOwl:hasDbXref "CAS:7493-90-5", "Gmelin:82500", "PMID:20717558" ; oboInOwl:hasExactSynonym "rel-(2R,3R)-butane-1,2,3,4-tetrol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R*,R*)-1,2,3,4-butanetetrol", "threo-tetritol" ; oboInOwl:id "CHEBI:26981" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "threitol" ; rdfs:subClassOf obo:CHEBI_48299 . obo:CHEBI_26986 obo:IAO_0000115 "An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group." ; chebi:charge "0" ; chebi:formula "C4H9NO3" ; chebi:mass "119.119" ; chebi:monoisotopicmass "119.05824" ; oboInOwl:hasDbXref "Beilstein:8204750", "CAS:80-68-2", "PMID:11379295", "PMID:15221503", "PMID:22264337", "Wikipedia:Threonine" ; oboInOwl:hasExactSynonym "threonine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Threonin" ; oboInOwl:id "CHEBI:26986" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "threonine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_38263, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50341 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32832 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32833 ] . obo:CHEBI_27024 obo:IAO_0000115 "Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:27024" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "toluenes" ; rdfs:subClassOf obo:CHEBI_22712 . obo:CHEBI_27026 obo:IAO_0000115 "Poisonous substance produced by a biological organism such as a microbe, animal or plant." ; oboInOwl:hasDbXref "Wikipedia:Toxin" ; oboInOwl:hasExactSynonym "toxin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "toxins" ; oboInOwl:id "CHEBI:27026" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "toxin" ; rdfs:subClassOf obo:CHEBI_25212, obo:CHEBI_64909 . obo:CHEBI_27027 obo:IAO_0000115 "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." ; oboInOwl:hasDbXref "Wikipedia:Micronutrient" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "micronutrients", "trace elements" ; oboInOwl:id "CHEBI:27027" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "micronutrient" ; rdfs:subClassOf obo:CHEBI_33284 . obo:CHEBI_27081 obo:IAO_0000115 "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." ; oboInOwl:hasExactSynonym "transition element" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Uebergangselement", "Uebergangsmetalle", "metal de transicion", "metal de transition", "metales de transicion", "metaux de transition", "transition element", "transition elements", "transition metal", "transition metals" ; oboInOwl:id "CHEBI:27081" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "transition element atom" ; rdfs:subClassOf obo:CHEBI_33521 . obo:CHEBI_27092 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tricarboxylate", "tricarboxylates", "tricarboxylic acid trianions" ; oboInOwl:id "CHEBI:27092" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tricarboxylic acid trianion" ; rdfs:subClassOf obo:CHEBI_35753, obo:CHEBI_38717 . obo:CHEBI_27093 obo:IAO_0000115 "An oxoacid containing three carboxy groups." ; chebi:charge "0" ; chebi:formula "C3H3O6R" ; chebi:mass "135.052" ; chebi:monoisotopicmass "134.99296" ; oboInOwl:hasDbXref "Wikipedia:Tricarboxylic_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Tricarbonsaeure", "Trikarbonsaeure", "tricarboxylic acids" ; oboInOwl:id "CHEBI:27093" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tricarboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35753 ] . obo:CHEBI_27136 obo:IAO_0000115 "A chemical compound containing three hydroxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "triols" ; oboInOwl:id "CHEBI:27136" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "triol" ; rdfs:subClassOf obo:CHEBI_26191 . obo:CHEBI_27150 oboInOwl:hasDbXref "Wikipedia:Trisaccharide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "trisaccharides" ; oboInOwl:id "CHEBI:27150" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trisaccharide" ; rdfs:subClassOf obo:CHEBI_50699 . obo:CHEBI_27162 obo:IAO_0000115 "Tryptamine and its substitution derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:27162" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptamines" ; rdfs:subClassOf obo:CHEBI_24828 . obo:CHEBI_27171 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heterobicyclic compounds", "organic heterobicyclic compounds" ; oboInOwl:id "CHEBI:27171" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic heterobicyclic compound" ; rdfs:subClassOf obo:CHEBI_33672, obo:CHEBI_38166 . obo:CHEBI_27207 obo:IAO_0000115 "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "univalent acyl group", "univalent carboacyl groups", "univalent carboxylic acyl groups" ; oboInOwl:id "CHEBI:27207" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "univalent carboacyl group" ; rdfs:subClassOf obo:CHEBI_37838 . obo:CHEBI_27208 obo:IAO_0000115 "Any fatty acid containing at least one C=C or C#C bond." ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMFA0103", "PMID:5322381" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkene acid", "olefinic acid", "unsaturated fatty acids" ; oboInOwl:id "CHEBI:27208" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "unsaturated fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_2580 ] . obo:CHEBI_27216 chebi:charge "-2" ; chebi:formula "C5H2N4O3" ; chebi:mass "166.09454" ; chebi:monoisotopicmass "166.01269" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "urate dianion" ; oboInOwl:id "CHEBI:27216" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urate(2-)" ; rdfs:subClassOf obo:CHEBI_25810, obo:CHEBI_46818, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30848 ] . obo:CHEBI_27226 obo:IAO_0000115 "An oxopurine that is the final oxidation product of purine metabolism." ; chebi:charge "0" ; chebi:formula "C5H4N4O3" ; chebi:mass "168.11042" ; chebi:monoisotopicmass "168.02834" ; oboInOwl:hasDbXref "HMDB:HMDB0000289", "Wikipedia:Uric_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "uric acids" ; oboInOwl:id "CHEBI:27226" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "uric acid" ; rdfs:subClassOf obo:CHEBI_25810, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30848 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_46818 ] . obo:CHEBI_27247 obo:IAO_0000115 "An monocarboxylic acid anion that is the conjugate base of urocanic acid." ; chebi:charge "-1" ; chebi:formula "C6H5N2O2" ; chebi:inchi "InChI=1S/C6H6N2O2/c9-6(10)2-1-5-3-7-4-8-5/h1-4H,(H,7,8)(H,9,10)/p-1" ; chebi:inchikey "LOIYMIARKYCTBW-UHFFFAOYSA-M" ; chebi:mass "137.11618" ; chebi:monoisotopicmass "137.03565" ; chebi:smiles "[H]C(=C([H])c1c[nH]cn1)C([O-])=O" ; oboInOwl:hasDbXref "ECMDB:ECMDB21396", "KEGG:C00785", "MetaCyc:UROCANATE" ; oboInOwl:hasExactSynonym "3-(1H-imidazol-4-yl)prop-2-enoate", "urocanate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:27247" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urocanate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27248 ] . obo:CHEBI_27248 obo:IAO_0000115 "An alpha,beta-unsaturated monocarboxylic acid that is prop-2-enoic acid substituted by a 1H-imidazol-4-yl group at position 3. It is a metabolite of hidtidine." ; chebi:charge "0" ; chebi:formula "C6H6N2O2" ; chebi:inchi "InChI=1S/C6H6N2O2/c9-6(10)2-1-5-3-7-4-8-5/h1-4H,(H,7,8)(H,9,10)" ; chebi:inchikey "LOIYMIARKYCTBW-UHFFFAOYSA-N" ; chebi:mass "138.12412" ; chebi:monoisotopicmass "138.04293" ; chebi:smiles "[H]C(=C([H])c1c[nH]cn1)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:8128219", "CAS:104-98-3", "ECMDB:ECMDB21396", "HMDB:HMDB0000301", "MetaCyc:UROCANATE", "PDBeChem:URO", "PMID:11669511", "PMID:24397532", "PMID:24627570", "Reaxys:8128219", "Wikipedia:Urocanic_acid" ; oboInOwl:hasExactSynonym "3-(1H-imidazol-4-yl)prop-2-enoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-(1H-imidazol-4-yl)-2-propenoic acid", "3-imidazol-4-ylacrylic acid" ; oboInOwl:id "CHEBI:27248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urocanic acid" ; rdfs:subClassOf obo:CHEBI_24780, obo:CHEBI_79020, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23240 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27247 ] . obo:CHEBI_27266 obo:IAO_0000115 "A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group." ; chebi:charge "0" ; chebi:formula "C5H11NO2" ; chebi:inchi "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)" ; chebi:inchikey "KZSNJWFQEVHDMF-UHFFFAOYSA-N" ; chebi:mass "117.14638" ; chebi:monoisotopicmass "117.07898" ; chebi:smiles "CC(C)C(N)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:506689", "CAS:516-06-3", "Gmelin:49877", "KEGG:C16436", "PMID:17190852", "PMID:22770225", "Reaxys:506689", "Wikipedia:Valine" ; oboInOwl:hasExactSynonym "valine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-methylbutanoic acid", "DL-valine", "Hval", "Valin", "valina" ; oboInOwl:id "CHEBI:27266" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "valine" ; rdfs:subClassOf obo:CHEBI_22918, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_30353 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32859 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32860 ] . obo:CHEBI_27300 obo:IAO_0000115 "Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body." ; oboInOwl:hasDbXref "MetaCyc:Vitamin-D", "Wikipedia:Vitamin_D" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D vitamins", "vitamin D vitamer", "vitamin D vitamers", "vitamin Ds", "vitamins D" ; oboInOwl:id "CHEBI:27300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin D" ; rdfs:subClassOf obo:CHEBI_36853, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24020 ] . obo:CHEBI_27311 obo:IAO_0000115 "Any plant metabolite that is found naturally as a component of a volatile oil." ; oboInOwl:hasDbXref "Wikipedia:Essential_oil" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "essential oil component", "essential oil components", "ethereal oil component", "ethereal oil components", "volatile oil components" ; oboInOwl:id "CHEBI:27311" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "volatile oil component" ; rdfs:subClassOf obo:CHEBI_52206, obo:CHEBI_76924 . obo:CHEBI_27314 obo:IAO_0000115 "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "wasserloesliche Vitamine", "water-soluble vitamin", "water-soluble vitamins" ; oboInOwl:id "CHEBI:27314" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "water-soluble vitamin (role)" ; rdfs:subClassOf obo:CHEBI_33229 . obo:CHEBI_27325 obo:IAO_0000115 "A subclass of carotenoids consisting of the oxygenated carotenes." ; oboInOwl:hasDbXref "DrugBank:DB00137" ; oboInOwl:hasExactSynonym "xanthophylls" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "xanthophylls" ; oboInOwl:id "CHEBI:27325" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "xanthophyll" ; rdfs:subClassOf obo:CHEBI_23044 . obo:CHEBI_27363 chebi:charge "0" ; chebi:formula "Zn" ; chebi:inchi "InChI=1S/Zn" ; chebi:inchikey "HCHKCACWOHOZIP-UHFFFAOYSA-N" ; chebi:mass "65.39000" ; chebi:monoisotopicmass "63.92914" ; chebi:smiles "[Zn]" ; oboInOwl:hasDbXref "CAS:7440-66-6", "Gmelin:16321", "KEGG:C00038", "PDBeChem:ZN", "WebElements:Zn" ; oboInOwl:hasExactSynonym "zinc" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "30Zn", "Zink", "Zn", "Zn(II)", "Zn2+", "cinc", "zinc", "zincum" ; oboInOwl:id "CHEBI:27363" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "zinc atom" ; rdfs:subClassOf obo:CHEBI_33340, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ] . obo:CHEBI_27369 obo:IAO_0000115 "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." ; oboInOwl:hasExactSynonym "zwitterion", "zwitterions" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "compose zwitterionique", "compuestos zwitterionicos", "zwitteriones", "zwitterionic compounds" ; oboInOwl:id "CHEBI:27369" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "zwitterion" ; rdfs:subClassOf obo:CHEBI_51151 . obo:CHEBI_27389 obo:IAO_0000115 "A beta-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group." ; chebi:charge "0" ; chebi:formula "C4H9NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)" ; chebi:inchikey "QCHPKSFMDHPSNR-UHFFFAOYSA-N" ; chebi:mass "103.11980" ; chebi:monoisotopicmass "103.06333" ; chebi:smiles "CC(CN)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:18712", "CHEBI:19959", "CHEBI:359" ; oboInOwl:hasDbXref "Beilstein:1720958", "Beilstein:1745458", "CAS:10569-72-9", "CAS:144-90-1", "Gmelin:1520758", "HMDB:HMDB0003911", "KEGG:C05145", "LIPID_MAPS_instance:LMFA01100054", "MetaCyc:3-AMINO-ISOBUTYRATE", "PMID:11785300", "PMID:14576092", "PMID:18299183", "PMID:18600547", "PMID:19186330", "PMID:19735301", "PMID:22735334", "PMID:2274753", "PMID:5776546", "PMID:639325", "PMID:8307374", "Reaxys:1720958", "Wikipedia:3-Aminoisobutyric_acid" ; oboInOwl:hasExactSynonym "3-amino-2-methylpropanoic acid", "3-aminoisobutyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-(aminomethyl)propionic acid", "2-Methyl-beta-alanine", "3-Amino-2-methylpropanoate", "3-Aminoisobutanoate", "3-Aminoisobutanoic acid", "BAIB", "DL-beta-aminoisobutyric acid", "alpha-Methyl-beta-alanine", "bAib", "beta-aminoisobutyric acid" ; oboInOwl:id "CHEBI:27389" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-aminoisobutyric acid" ; rdfs:subClassOf obo:CHEBI_33706, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16135 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_49096 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_142590 ] . obo:CHEBI_27470 obo:IAO_0000115 "An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation." ; chebi:charge "0" ; chebi:formula "C19H19N7O6" ; chebi:inchi "InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1" ; chebi:inchikey "OVBPIULPVIDEAO-LBPRGKRZSA-N" ; chebi:mass "441.39750" ; chebi:monoisotopicmass "441.13968" ; chebi:smiles "Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1" ; oboInOwl:hasAlternativeId "CHEBI:24075", "CHEBI:42610", "CHEBI:5140", "CHEBI:569217" ; oboInOwl:hasDbXref "AGR:IND606960789", "Beilstein:100781", "CAS:59-30-3", "Chemspider:5815", "DrugBank:DB00158", "Drug_Central:1231", "FooDB:FDB014504", "HMDB:HMDB0000121", "KEGG:C00504", "KEGG:D00070", "KNApSAcK:C00001539", "LINCS:LSM-5355", "MetaCyc:CPD-12826", "PDBeChem:FOL", "PMID:10138938", "PMID:10897644", "PMID:10958818", "PMID:11261364", "PMID:11451208", "PMID:11959400", "PMID:14387833", "PMID:15321809", "PMID:15523939", "PMID:15754725", "PMID:15797531", "PMID:15797685", "PMID:15831910", "PMID:15990733", "PMID:16093404", "PMID:16277678", "PMID:16380297", "PMID:16871332", "PMID:17784727", "PMID:18788725", "PMID:19121630", "PMID:19335717", "PMID:19355913", "PMID:24650098", "PMID:33624660", "PMID:33965562", "PMID:33968971", "PMID:34207319", "PMID:34219855", "PMID:7738698", "PMID:8235383", "PMID:9040515", "PMID:9420019", "PMID:9565830", "PMID:9683174", "PMID:9781393", "PMID:9808640", "PMID:9808641", "Reaxys:100781", "Wikipedia:Folic_Acid" ; oboInOwl:hasExactSynonym "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid", "Acfol", "Folate", "Folicet", "Folsaeure", "N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid", "N-pteroyl-L-glutamic acid", "PGA", "PteGlu", "acide folique", "acido folico", "acidum folicum", "folic acid", "pteroyl-L-glutamic acid", "pteroyl-L-monoglutamic acid", "pteroylglutamic acid", "pteroylmonoglutamic acid", "vitamin B11", "vitamin B9", "vitamin Bc", "vitamin Be", "vitamin M" ; oboInOwl:id "CHEBI:27470" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "folic acid" ; rdfs:subClassOf obo:CHEBI_37445, obo:CHEBI_51569, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33284 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_38794 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_62501 ] . obo:CHEBI_27547 chebi:charge "0" ; chebi:formula "C40H56O2" ; chebi:inchi "InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1" ; chebi:inchikey "JKQXZKUSFCKOGQ-QAYBQHTQSA-N" ; chebi:mass "568.87144" ; chebi:monoisotopicmass "568.42803" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\C1=C(C)C[C@@H](O)CC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C[C@@H](O)CC1(C)C" ; oboInOwl:hasAlternativeId "CHEBI:10108", "CHEBI:27361" ; oboInOwl:hasDbXref "Beilstein:2068416", "CAS:144-68-3", "KEGG:C06098", "KNApSAcK:C00000931", "LIPID_MAPS_instance:LMPR01070261", "MetaCyc:CPD1F-130", "Wikipedia:Zeaxanthin" ; oboInOwl:hasExactSynonym "(3R,3'R)-beta,beta-carotene-3,3'-diol", "Zeaxanthin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(3R,3'R)-dihydroxy-beta,beta-carotene", "all-trans-beta-carotene-3,3'-diol", "all-trans-zeaxanthin", "anchovyxanthin", "beta,beta-carotene-3,3'-diol" ; oboInOwl:id "CHEBI:27547" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "zeaxanthin" ; rdfs:subClassOf obo:CHEBI_23045, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76969 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_17579 ] . obo:CHEBI_27570 obo:IAO_0000115 "An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3." ; chebi:charge "0" ; chebi:formula "C6H9N3O2" ; chebi:inchi "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)" ; chebi:inchikey "HNDVDQJCIGZPNO-UHFFFAOYSA-N" ; chebi:mass "155.15468" ; chebi:monoisotopicmass "155.06948" ; chebi:smiles "NC(Cc1c[nH]cn1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24598", "CHEBI:43118", "CHEBI:5733" ; oboInOwl:hasDbXref "Beilstein:84087", "CAS:4998-57-6", "Gmelin:3656", "KEGG:C00768", "KNApSAcK:C00001363", "PMID:17190852", "PMID:22264337", "PMID:22770225", "PMID:29286160", "Reaxys:84087", "Wikipedia:Histidine" ; oboInOwl:hasExactSynonym "2-amino-3-(1H-imidazol-4-yl)propanoic acid", "Histidine", "histidine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DL-Histidine", "Histidin", "alpha-Amino-1H-imidazole-4-propionic acid", "histidina" ; oboInOwl:id "CHEBI:27570" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidine" ; rdfs:subClassOf obo:CHEBI_24780, obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_33856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50338 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32529 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32531 ] . obo:CHEBI_27584 obo:IAO_0000115 "A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." ; chebi:charge "0" ; chebi:formula "C21H28O5" ; chebi:inchi "InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1" ; chebi:inchikey "PQSUYGKTWSAVDQ-ZVIOFETBSA-N" ; chebi:mass "360.44400" ; chebi:monoisotopicmass "360.19367" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO" ; oboInOwl:hasAlternativeId "CHEBI:22306", "CHEBI:2563", "CHEBI:40919" ; oboInOwl:hasDbXref "Beilstein:3224996", "CAS:52-39-1", "DrugBank:DB04630", "Drug_Central:111", "HMDB:HMDB0000037", "KEGG:C01780", "LINCS:LSM-42770", "LIPID_MAPS_instance:LMST02030026", "PDBeChem:AS4", "PMID:10438974", "Reaxys:3224996", "Wikipedia:Aldosterone" ; oboInOwl:hasExactSynonym "11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al", "ALDOSTERONE", "Aldosterone", "aldosterone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-aldosterone", "(11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al", "11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al" ; oboInOwl:id "CHEBI:27584" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldosterone" ; rdfs:subClassOf obo:CHEBI_131565, obo:CHEBI_139590, obo:CHEBI_25354, obo:CHEBI_35344, obo:CHEBI_35346, obo:CHEBI_36885, obo:CHEBI_36887, obo:CHEBI_47909, obo:CHEBI_64600, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_8386 ] . obo:CHEBI_27594 chebi:charge "0" ; chebi:formula "C" ; chebi:inchi "InChI=1S/C" ; chebi:inchikey "OKTJSMMVPCPJKN-UHFFFAOYSA-N" ; chebi:mass "12.01070" ; chebi:monoisotopicmass "12.00000" ; chebi:smiles "[C]" ; oboInOwl:hasAlternativeId "CHEBI:23009", "CHEBI:3399" ; oboInOwl:hasDbXref "CAS:7440-44-0", "KEGG:C06265", "WebElements:C" ; oboInOwl:hasExactSynonym "carbon" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "6C", "C", "Carbon", "Kohlenstoff", "carbon", "carbone", "carbonium", "carbono" ; oboInOwl:id "CHEBI:27594" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon atom" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33306, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_27612 chebi:charge "0" ; chebi:formula "C3H4N2O2" ; chebi:inchi "InChI=1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)" ; chebi:inchikey "WJRBRSLFGCUECM-UHFFFAOYSA-N" ; chebi:mass "100.07614" ; chebi:monoisotopicmass "100.02728" ; chebi:smiles "O=C1CNC(=O)N1" ; oboInOwl:hasAlternativeId "CHEBI:24625", "CHEBI:5773" ; oboInOwl:hasDbXref "Beilstein:110598", "CAS:461-72-3", "Gmelin:101266", "KEGG:C05146", "PDBeChem:HYN" ; oboInOwl:hasExactSynonym "Hydantoin", "imidazolidine-2,4-dione" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,4(3H,5H)-imidazoledione", "2,4-imidazolidinedione", "Glycolylurea", "imidazole-2,4(3H,5H)-dione" ; oboInOwl:id "CHEBI:27612" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydantoin" ; rdfs:subClassOf obo:CHEBI_24628 . obo:CHEBI_27622 obo:IAO_0000115 "A hydroxy monocarboxylic acid anion that is the conjugate base of vanillylmandelic acid." ; chebi:charge "-1" ; chebi:formula "C9H9O5" ; chebi:inchi "InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1" ; chebi:inchikey "CGQCWMIAEPEHNQ-UHFFFAOYSA-M" ; chebi:mass "197.16480" ; chebi:monoisotopicmass "197.04555" ; chebi:smiles "COc1cc(ccc1O)C(O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:1573", "CHEBI:20105" ; oboInOwl:hasDbXref "KEGG:C05584" ; oboInOwl:hasExactSynonym "2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-Methoxy-4-hydroxymandelate", "vanilmandelate" ; oboInOwl:id "CHEBI:27622" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vanillylmandelate" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_25147 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_20106 ] . obo:CHEBI_27638 obo:IAO_0000115 "A cobalt group element atom that has atomic number 27." ; chebi:charge "0" ; chebi:formula "Co" ; chebi:inchi "InChI=1S/Co" ; chebi:inchikey "GUTLYIVDDKVIGB-UHFFFAOYSA-N" ; chebi:mass "58.93320" ; chebi:monoisotopicmass "58.93319" ; chebi:smiles "[Co]" ; oboInOwl:hasAlternativeId "CHEBI:23335", "CHEBI:3788" ; oboInOwl:hasDbXref "CAS:7440-48-4", "KEGG:C00175", "KEGG:C19171", "PDBeChem:3CO", "WebElements:Co" ; oboInOwl:hasExactSynonym "cobalt" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "27Co", "Co", "Cobalt", "Kobalt", "cobalt", "cobalto", "cobaltum" ; oboInOwl:id "CHEBI:27638" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt atom" ; rdfs:subClassOf obo:CHEBI_33358, obo:CHEBI_88184, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ] . obo:CHEBI_27780 obo:IAO_0000115 "A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions." ; oboInOwl:hasAlternativeId "CHEBI:23648", "CHEBI:4456" ; oboInOwl:hasDbXref "KEGG:C01689" ; oboInOwl:hasExactSynonym "detergent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Detergents" ; oboInOwl:id "CHEBI:27780" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "detergent" ; rdfs:subClassOf obo:CHEBI_33232, obo:CHEBI_35195 . obo:CHEBI_27897 obo:IAO_0000115 "An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3." ; chebi:charge "0" ; chebi:formula "C11H12N2O2" ; chebi:inchi "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)" ; chebi:inchikey "QIVBCDIJIAJPQS-UHFFFAOYSA-N" ; chebi:mass "204.22526" ; chebi:monoisotopicmass "204.08988" ; chebi:smiles "NC(Cc1c[nH]c2ccccc12)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:27163", "CHEBI:9769" ; oboInOwl:hasDbXref "Beilstein:86196", "CAS:54-12-6", "Gmelin:4532", "KEGG:C00806", "KNApSAcK:C00001396", "LINCS:LSM-36836", "PMID:17439666", "PMID:22264337", "Reaxys:86196", "Wikipedia:Tryptophan" ; oboInOwl:hasExactSynonym "Tryptophan", "tryptophan" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-(1H-indol-3-yl)propanoic acid", "Htrp", "Trp", "W", "alpha-Amino-beta-(3-indolyl)-propionic acid", "alpha-amino-beta-3-indolepropionic acid", "beta-3-indolylalanine", "triptofano", "tryptophane" ; oboInOwl:id "CHEBI:27897" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptophan" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, obo:CHEBI_33856, obo:CHEBI_38631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50337 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32727 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32728 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_64554 ] . obo:CHEBI_28044 obo:IAO_0000115 "An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group." ; chebi:charge "0" ; chebi:formula "C9H11NO2" ; chebi:inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)" ; chebi:inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-N" ; chebi:mass "165.18918" ; chebi:monoisotopicmass "165.07898" ; chebi:smiles "NC(Cc1ccccc1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:25984", "CHEBI:8089" ; oboInOwl:hasDbXref "Beilstein:1910407", "CAS:150-30-1", "Gmelin:50836", "KEGG:C02057", "PMID:17439666", "PMID:22264337", "Reaxys:1910407", "Wikipedia:Phenylalanine" ; oboInOwl:hasExactSynonym "2-amino-3-phenylpropanoic acid", "Phenylalanine", "phenylalanine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DL-Phenylalanine", "F", "PHE", "Phenylalanin", "alpha-Amino-beta-phenylpropionic acid", "fenilalanina" ; oboInOwl:id "CHEBI:28044" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylalanine" ; rdfs:subClassOf obo:CHEBI_33704, obo:CHEBI_33856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_22744 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32504 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32505 ] . obo:CHEBI_28050 obo:IAO_0000115 "A histidine derivative that is histidine in which one of the hydrogens attached to the alpha-amino group has been replaced by a 4-aminobutanoyl group." ; chebi:charge "0" ; chebi:formula "C10H16N4O3" ; chebi:inchi "InChI=1S/C10H16N4O3/c11-3-1-2-9(15)14-8(10(16)17)4-7-5-12-6-13-7/h5-6,8H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)" ; chebi:inchikey "CCLQKVKJOGVQLU-UHFFFAOYSA-N" ; chebi:mass "240.25900" ; chebi:monoisotopicmass "240.12224" ; chebi:smiles "NCCCC(=O)NC(Cc1c[nH]cn1)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24607", "CHEBI:5750" ; oboInOwl:hasDbXref "Reaxys:11612459" ; oboInOwl:hasExactSynonym "N-(4-aminobutanoyl)histidine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-(4-aminobutyryl)histidine", "gamma-Aminobutyryl histidine" ; oboInOwl:id "CHEBI:28050" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homocarnosine" ; rdfs:subClassOf obo:CHEBI_24599, obo:CHEBI_24780, obo:CHEBI_51569, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16865 ] . obo:CHEBI_28087 obo:IAO_0000115 "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." ; oboInOwl:hasAlternativeId "CHEBI:24379", "CHEBI:5466" ; oboInOwl:hasDbXref "CAS:9005-79-2", "GlyGen:G99991IU", "GlyTouCan:G99991IU", "HMDB:HMDB0000757", "KEGG:C00182", "MetaCyc:CPD0-971", "Wikipedia:Glycogen" ; oboInOwl:hasExactSynonym "Glycogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1", "animal starch", "liver starch" ; oboInOwl:id "CHEBI:28087" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycogen" ; rdfs:subClassOf obo:CHEBI_24384, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ] . obo:CHEBI_28115 chebi:charge "0" ; chebi:formula "C63H91CoN13O14P" ; chebi:inchi "InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1" ; chebi:inchikey "JEWJRMKHSMTXPP-WZHZPDAFSA-L" ; chebi:mass "1344.38230" ; chebi:monoisotopicmass "1343.58780" ; chebi:smiles "[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]4[C@@H](O)[C@H](O[C@@H]4CO)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O" ; oboInOwl:hasAlternativeId "CHEBI:25291", "CHEBI:48831", "CHEBI:6869" ; oboInOwl:hasDbXref "CAS:13422-55-4", "COMe:MOL000085", "DrugBank:DB03614", "Gmelin:124528", "KEGG:C06453", "KEGG:D03246", "PDBeChem:COB" ; oboInOwl:hasExactSynonym "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide", "Methylcobalamin", "methylcobalamin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CO-METHYLCOBALAMIN", "MeCbl", "mecobalamin", "methylcob(III)alamin" ; oboInOwl:id "CHEBI:28115" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylcobalamin" ; rdfs:subClassOf obo:CHEBI_140785, obo:CHEBI_23334, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_28159 obo:IAO_0000115 "An optically active form of asparagine having D-configuration." ; chebi:charge "0" ; chebi:formula "C4H8N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m1/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-UWTATZPHSA-N" ; chebi:mass "132.119" ; chebi:monoisotopicmass "132.05349" ; chebi:smiles "OC([C@@H](CC(N)=O)N)=O" ; oboInOwl:hasAlternativeId "CHEBI:20918", "CHEBI:4107" ; oboInOwl:hasDbXref "Beilstein:1723526", "CAS:2058-58-4", "DrugBank:DB03943", "Gmelin:101784", "HMDB:HMDB0033780", "KEGG:C01905", "MetaCyc:CPD-3633", "PDBeChem:DSG", "PMID:767332", "Patent:CN101333175", "Reaxys:1723526", "YMDB:YMDB00849" ; oboInOwl:hasExactSynonym "D-Asparagine", "D-asparagine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2,4-diamino-4-oxobutanoic acid", "(2R)-2-amino-3-carbamoylpropanoic acid", "(R)-2-amino-3-carbamoylpropanoic acid", "D-2-aminosuccinamic acid", "D-Asparagin", "D-aspartic acid beta-amide", "DSG" ; oboInOwl:id "CHEBI:28159" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-asparagine" ; rdfs:subClassOf obo:CHEBI_16733, obo:CHEBI_22653, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32656 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32657 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17196 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_74337 ] . obo:CHEBI_28260 obo:IAO_0000115 "An aldohexose that is the C-4 epimer of glucose." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:24162", "CHEBI:33933", "CHEBI:5256" ; oboInOwl:hasDbXref "CAS:26566-61-0", "KEGG:C01582", "Wikipedia:Galactose" ; oboInOwl:hasExactSynonym "Galactose", "galacto-hexose", "galactose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Gal", "Galaktose" ; oboInOwl:id "CHEBI:28260" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactose" ; rdfs:subClassOf obo:CHEBI_33917, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ] . obo:CHEBI_28300 obo:IAO_0000115 "An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4." ; chebi:charge "0" ; chebi:formula "C5H10N2O3" ; chebi:inchi "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)" ; chebi:inchikey "ZDXPYRJPNDTMRX-UHFFFAOYSA-N" ; chebi:mass "146.14458" ; chebi:monoisotopicmass "146.06914" ; chebi:smiles "NC(CCC(N)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24316", "CHEBI:5432" ; oboInOwl:hasDbXref "Beilstein:1723795", "CAS:585-21-7", "CAS:6899-04-3", "Gmelin:27318", "KEGG:C00303", "KNApSAcK:C00001359", "Reaxys:1723795", "Wikipedia:Glutamine" ; oboInOwl:hasExactSynonym "Glutamine", "glutamine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,5-diamino-5-oxopentanoic acid", "2-Aminoglutaramic acid", "2-amino-4-carbamoylbutanoic acid", "Glutamin", "Glutaminsaeure-5-amid", "Hgln", "glutamic acid gamma-amide" ; oboInOwl:id "CHEBI:28300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamine" ; rdfs:subClassOf obo:CHEBI_26167, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50331 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32678 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32679 ] . obo:CHEBI_28358 obo:IAO_0000115 "A racemate comprising equimolar amounts of (R)- and (S)-lactic acid." ; chebi:charge "0" ; chebi:formula "C3H6O3" ; chebi:inchi "InChI=1S/2C3H6O3/c2*1-2(4)3(5)6/h2*2,4H,1H3,(H,5,6)/t2*2-/m10/s1" ; chebi:inchikey "KVZLHPXEUGJPAH-QNDGGIRCSA-N" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; chebi:smiles "C(=O)([C@@H](O)C)O.C(=O)([C@H](O)C)O" ; oboInOwl:hasAlternativeId "CHEBI:24998", "CHEBI:6351" ; oboInOwl:hasDbXref "Beilstein:1209341", "CAS:50-21-5", "DrugBank:DB04398", "KEGG:C01432", "KEGG:D00111", "LIPID_MAPS_instance:LMFA01050002", "PMID:17190852", "PMID:29079364", "Reaxys:1209341", "Wikipedia:Lactic_acid" ; oboInOwl:hasExactSynonym "rac-2-hydroxypropanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+-)-2-hydroxypropanoic acid", "2-Hydroxypropanoic acid", "2-Hydroxypropionic acid", "E270", "Lactic acid", "Milchsaeure", "alpha-hydroxypropanoic acid", "alpha-hydroxypropionic acid" ; oboInOwl:id "CHEBI:28358" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "rac-lactic acid" ; rdfs:subClassOf obo:CHEBI_60911, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_42111 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_422 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64049 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_24996 ] . obo:CHEBI_28383 oboInOwl:hasAlternativeId "CHEBI:10197", "CHEBI:13780", "CHEBI:22361" ; oboInOwl:hasDbXref "KEGG:C04025" ; oboInOwl:hasExactSynonym "alpha,omega-Dicarboxylic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha(omega)-Dicarboxylic acid", "alpha,omega-dicarboxylic acids" ; oboInOwl:id "CHEBI:28383" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha,omega-dicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35692 . obo:CHEBI_28384 obo:IAO_0000115 "Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors." ; oboInOwl:hasAlternativeId "CHEBI:10009", "CHEBI:27301", "CHEBI:27307" ; oboInOwl:hasDbXref "CAS:12001-79-5", "KEGG:C01628", "MetaCyc:CPD-11501", "PMID:26413183", "PMID:33255760", "PMID:34109217", "Wikipedia:Vitamin_K" ; oboInOwl:hasExactSynonym "Vitamin K" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vitamin K vitamer", "vitamin K vitamers", "vitamine K", "vitamins K" ; oboInOwl:id "CHEBI:28384" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin K" ; rdfs:subClassOf obo:CHEBI_132142, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24020 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ] . obo:CHEBI_28425 obo:IAO_0000115 "A cyclic carotene with a beta- and an epsilon-ring at opposite ends respectively." ; chebi:charge "0" ; chebi:formula "C40H56" ; chebi:inchi "InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+" ; chebi:inchikey "ANVAOWXLWRTKGA-JLTXGRSLSA-N" ; chebi:mass "536.87264" ; chebi:monoisotopicmass "536.43820" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\C1C(C)=CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C" ; oboInOwl:hasAlternativeId "CHEBI:10215", "CHEBI:22447" ; oboInOwl:hasDbXref "Beilstein:2067408", "Beilstein:3227599", "CAS:432-70-2", "HMDB:HMDB0003993", "KEGG:C05433", "KNApSAcK:C00003765", "LIPID_MAPS_instance:LMPR01070258", "PMID:23620017", "PMID:24169341", "PMID:9408998", "Reaxys:2682045" ; oboInOwl:hasExactSynonym "alpha-Carotene", "alpha-carotene", "beta,epsilon-carotene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "all-trans-alpha-carotene" ; oboInOwl:id "CHEBI:28425" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-carotene" ; rdfs:subClassOf obo:CHEBI_139120, obo:CHEBI_35163, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_67200 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ] . obo:CHEBI_28616 obo:IAO_0000115 "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." ; chebi:charge "0" ; chebi:formula "CH3NO2" ; chebi:inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)" ; chebi:inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-N" ; chebi:mass "61.04006" ; chebi:monoisotopicmass "61.01638" ; chebi:smiles "NC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:22504", "CHEBI:23002", "CHEBI:3386", "CHEBI:44573" ; oboInOwl:hasDbXref "Beilstein:1734754", "CAS:463-77-4", "DrugBank:DB04261", "Gmelin:130345", "KEGG:C01563", "PDBeChem:OUT", "Wikipedia:Carbamic_acid" ; oboInOwl:hasExactSynonym "CARBAMIC ACID", "Carbamic acid", "carbamic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aminoameisensaeure", "Aminoformic acid", "Carbamate", "Carbamidsaeure" ; oboInOwl:id "CHEBI:28616" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbamic acid" ; rdfs:subClassOf obo:CHEBI_35352, obo:CHEBI_35605, obo:CHEBI_64708, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_13941 ] . obo:CHEBI_28659 chebi:charge "0" ; chebi:formula "P" ; chebi:inchi "InChI=1S/P" ; chebi:inchikey "OAICVXFJPJFONN-UHFFFAOYSA-N" ; chebi:mass "30.97376" ; chebi:monoisotopicmass "30.97376" ; chebi:smiles "[P]" ; oboInOwl:hasAlternativeId "CHEBI:26080", "CHEBI:8168" ; oboInOwl:hasDbXref "CAS:7723-14-0", "Gmelin:16235", "KEGG:C06262", "WebElements:P" ; oboInOwl:hasExactSynonym "phosphorus" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "15P", "P", "Phosphor", "Phosphorus", "fosforo", "phosphore", "phosphorus" ; oboInOwl:id "CHEBI:28659" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphorus atom" ; rdfs:subClassOf obo:CHEBI_25585, obo:CHEBI_33300, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_28689 obo:IAO_0000115 "An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands." ; chebi:charge "0" ; chebi:formula "C19H28O2" ; chebi:inchi "InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1" ; chebi:inchikey "FMGSKLZLMKYGDP-USOAJAOKSA-N" ; chebi:mass "288.42440" ; chebi:monoisotopicmass "288.20893" ; chebi:smiles "[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]" ; oboInOwl:hasAlternativeId "CHEBI:11911", "CHEBI:1723", "CHEBI:20246", "CHEBI:40738", "CHEBI:86953" ; oboInOwl:hasDbXref "CAS:53-43-0", "DrugBank:DB01708", "Drug_Central:795", "HMDB:HMDB0000077", "KEGG:C01227", "KEGG:D08409", "LIPID_MAPS_instance:LMST02020021", "MetaCyc:3-BETA-HYDROXYANDROST-5-EN-17-ONE", "PDBeChem:AND", "PMID:14662261", "PMID:18634257", "PMID:24256992", "PMID:24424045", "Reaxys:2058110", "Wikipedia:Dehydroepiandrosterone" ; oboInOwl:hasExactSynonym "3beta-hydroxyandrost-5-en-17-one", "Dehydroepiandrosterone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-BETA-HYDROXY-5-ANDROSTEN-17-ONE", "3beta-Hydroxyandrost-5-en-17-one", "3beta-hydroxyandrost-5-en-17-one", "DHA", "DHEA", "Dehydroisoandrosterone", "Intrarosa", "Prasterone" ; oboInOwl:id "CHEBI:28689" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dehydroepiandrosterone" ; rdfs:subClassOf obo:CHEBI_1722, obo:CHEBI_19168, obo:CHEBI_50402, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_28694 chebi:charge "0" ; chebi:formula "Cu" ; chebi:inchi "InChI=1S/Cu" ; chebi:inchikey "RYGMFSIKBFXOCR-UHFFFAOYSA-N" ; chebi:mass "63.54600" ; chebi:monoisotopicmass "62.92960" ; chebi:smiles "[Cu]" ; oboInOwl:hasAlternativeId "CHEBI:23376", "CHEBI:3874" ; oboInOwl:hasDbXref "CAS:7440-50-8", "Gmelin:16269", "KEGG:C00070", "WebElements:Cu" ; oboInOwl:hasExactSynonym "copper" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "29Cu", "Copper", "Cu", "Kupfer", "cobre", "copper", "cuivre", "cuprum" ; oboInOwl:id "CHEBI:28694" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "copper atom" ; rdfs:subClassOf obo:CHEBI_33366, obo:CHEBI_88184, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ] . obo:CHEBI_28789 obo:IAO_0000115 "The L-enantiomer of glucitol." ; chebi:charge "0" ; chebi:formula "C6H14O6" ; chebi:inchi "InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m0/s1" ; chebi:inchikey "FBPFZTCFMRRESA-FSIIMWSLSA-N" ; chebi:mass "182.17176" ; chebi:monoisotopicmass "182.07904" ; chebi:smiles "OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:21394", "CHEBI:6223" ; oboInOwl:hasDbXref "Beilstein:1721906", "CAS:6706-59-8", "ECMDB:ECMDB00247", "Gmelin:648560", "KEGG:C01722", "MetaCyc:CPD-12810", "PMID:19695255", "Reaxys:1721906", "YMDB:YMDB00724" ; oboInOwl:hasExactSynonym "L-Glucitol", "L-glucitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R,3S,4S,5S)-hexane-1,2,3,4,5,6-hexol", "D-Gulitol", "D-gulitol", "L-Sorbitol", "L-sorbitol" ; oboInOwl:id "CHEBI:28789" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glucitol" ; rdfs:subClassOf obo:CHEBI_30911, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_17924 ] . obo:CHEBI_28790 obo:IAO_0000115 "A primary amino compound that is the 5-hydroxy derivative of tryptamine." ; chebi:charge "0" ; chebi:formula "C10H12N2O" ; chebi:inchi "InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2" ; chebi:inchikey "QZAYGJVTTNCVMB-UHFFFAOYSA-N" ; chebi:mass "176.215" ; chebi:monoisotopicmass "176.09496" ; chebi:smiles "C1=CC(=CC=2C(=CNC12)CCN)O" ; oboInOwl:hasAlternativeId "CHEBI:1420", "CHEBI:26652", "CHEBI:49894" ; oboInOwl:hasDbXref "Beilstein:143524", "CAS:50-67-9", "Gmelin:1861995", "HMDB:HMDB0000259", "KEGG:C00780", "KNApSAcK:C00001429", "LINCS:LSM-6589", "MetaCyc:SEROTONIN", "PDBeChem:SRO", "PMID:18593914", "PMID:22770225", "PMID:24136337", "Reaxys:143524", "Wikipedia:Serotonin" ; oboInOwl:hasExactSynonym "3-(2-aminoethyl)-1H-indol-5-ol", "SEROTONIN", "Serotonin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-(2-Aminoethyl)-1H-indol-5-ol", "5-HT", "5-Hydroxytryptamine", "Enteramine", "serotonine", "thrombocytin", "thrombotonin" ; oboInOwl:id "CHEBI:28790" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serotonin" ; rdfs:subClassOf obo:CHEBI_25375, obo:CHEBI_27162, obo:CHEBI_33853, obo:CHEBI_50994, obo:CHEBI_84729, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25512 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16765 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_350546 ] . obo:CHEBI_28815 obo:IAO_0000115 "A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit." ; chebi:charge "0" ; chebi:formula "(C12H19NO20S3)n" ; oboInOwl:hasAlternativeId "CHEBI:24502", "CHEBI:24507", "CHEBI:5661" ; oboInOwl:hasDbXref "Beilstein:8186767", "CAS:9050-30-0", "KEGG:C00925", "KEGG:D08536", "PMID:8713797" ; oboInOwl:hasExactSynonym "Heparan sulfate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Heparan N-sulfate", "Heparan sulphate", "Heparatan sulfate", "Heparin monosulfate", "Heparin sulfate", "Heparitin monosulfate", "Heparitin sulfate", "N-Acetylheparan sulfate" ; oboInOwl:id "CHEBI:28815" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heparan sulfate" ; rdfs:subClassOf obo:CHEBI_35721, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_157750 ] . obo:CHEBI_28838 chebi:charge "0" ; chebi:formula "C40H56O2" ; chebi:inchi "InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-25,35-37,41-42H,26-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36+,37-/m0/s1" ; chebi:inchikey "KBPHJBAIARWVSC-RGZFRNHPSA-N" ; chebi:mass "568.87144" ; chebi:monoisotopicmass "568.42803" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\[C@H]1C(C)=C[C@H](O)CC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C[C@@H](O)CC1(C)C" ; oboInOwl:hasAlternativeId "CHEBI:27324", "CHEBI:43817", "CHEBI:6576" ; oboInOwl:hasDbXref "Beilstein:2068550", "CAS:127-40-2", "DrugBank:DB00137", "Drug_Central:4145", "HMDB:HMDB0003233", "KEGG:C08601", "KNApSAcK:C00003776", "LIPID_MAPS_instance:LMPR01070274", "MetaCyc:CPD1F-119", "PDBeChem:LUT", "PMID:10714278", "PMID:14670087", "PMID:23543147", "PMID:24451312", "Reaxys:2068550", "Wikipedia:Lutein" ; oboInOwl:hasExactSynonym "(3R,3'R,6'R)-beta,epsilon-carotene-3,3'-diol", "Lutein", "lutein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL", "Bo-Xan", "E 161b", "Xanthophyll" ; oboInOwl:id "CHEBI:28838" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lutein" ; rdfs:subClassOf obo:CHEBI_23045, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77182 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35147 ] . obo:CHEBI_28842 obo:IAO_0000115 "A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics." ; chebi:charge "0" ; chebi:formula "C18H36O2" ; chebi:inchi "InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)" ; chebi:inchikey "QIQXTHQIDYTFRH-UHFFFAOYSA-N" ; chebi:mass "284.478" ; chebi:monoisotopicmass "284.27153" ; chebi:smiles "C(CCCCCCCCCC)CCCCCCC(=O)O" ; oboInOwl:hasAlternativeId "CHEBI:25631", "CHEBI:45710" ; oboInOwl:hasDbXref "Beilstein:608585", "CAS:57-11-4", "DrugBank:DB03193", "Drug_Central:4611", "Gmelin:11738", "HMDB:HMDB0000827", "KEGG:C01530", "KEGG:D00119", "KNApSAcK:C00001238", "LIPID_MAPS_instance:LMFA01010018", "MetaCyc:STEARIC_ACID", "PDBeChem:STE", "PMID:11425337", "PMID:16448636", "PMID:17439666", "PMID:18982377", "PMID:19468063", "PMID:19838949", "PMID:22735334", "PMID:26884207", "PMID:7763343", "Reaxys:608585", "Wikipedia:Stearic_acid" ; oboInOwl:hasExactSynonym "Octadecanoic acid", "octadecanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "18:0", "C18:0", "CH3-[CH2]16-COOH", "Octadecansaeure", "Oktadekansaeure", "STEARIC ACID", "Stearinsaeure", "acide octadecanoique", "acide stearique", "n-octadecanoic acid", "octadecoic acid", "stearic acid" ; oboInOwl:id "CHEBI:28842" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "octadecanoic acid" ; rdfs:subClassOf obo:CHEBI_15904, obo:CHEBI_26607, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_32926 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_25629 ] . obo:CHEBI_28868 obo:IAO_0000115 "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.00950" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13634", "CHEBI:24022", "CHEBI:4985" ; oboInOwl:hasDbXref "KEGG:C02403", "PMID:18628202" ; oboInOwl:hasExactSynonym "Fatty acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alkanate", "Fettsaeureanion", "Fettsaeureanionen", "a fatty acid", "acido graso anionico", "acidos grasos anionicos", "anion de l'acide gras", "fatty acid anions" ; oboInOwl:id "CHEBI:28868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35366 ] . obo:CHEBI_28875 obo:IAO_0000115 "A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat." ; chebi:charge "0" ; chebi:formula "C14H28O2" ; chebi:inchi "InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)" ; chebi:inchikey "TUNFSRHWOTWDNC-UHFFFAOYSA-N" ; chebi:mass "228.37090" ; chebi:monoisotopicmass "228.20893" ; chebi:smiles "CCCCCCCCCCCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:26897", "CHEBI:278516", "CHEBI:44232", "CHEBI:7056", "CHEBI:73168" ; oboInOwl:hasDbXref "Beilstein:508624", "CAS:544-63-8", "DrugBank:DB08231", "Gmelin:242115", "HMDB:HMDB0000806", "KEGG:C06424", "KNApSAcK:C00001228", "LIPID_MAPS_instance:LMFA01010014", "MetaCyc:CPD-7836", "PDBeChem:MYR", "PMID:13129458", "PMID:15149689", "PMID:16509590", "PMID:16554156", "PMID:19154695", "PMID:19761868", "PMID:19786012", "PMID:19902021", "PMID:19955401", "PMID:20634506", "PMID:20920594", "PMID:21955528", "PMID:22030224", "PMID:27206979", "PMID:28600633", "PMID:6802973", "Reaxys:508624", "Wikipedia:Myristic_acid" ; oboInOwl:hasExactSynonym "Tetradecanoic acid", "myristic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-tetradecanecarboxylic acid", "14", "14:0", "14:00", "C14", "CH3-[CH2]12-COOH", "MYRISTIC ACID", "Myristic acid", "Myristinsaeure", "acide tetradecanoique", "n-Tetradecan-1-oic acid", "n-Tetradecoic acid", "n-tetradecanoic acid", "tetradecoic acid" ; oboInOwl:id "CHEBI:28875" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetradecanoic acid" ; rdfs:subClassOf obo:CHEBI_15904, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78444 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30807 ] . obo:CHEBI_28892 obo:IAO_0000115 "A molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain." ; oboInOwl:hasAlternativeId "CHEBI:26669", "CHEBI:36525", "CHEBI:5274" ; oboInOwl:hasDbXref "KEGG:C01808", "LIPID_MAPS_class:LMSP0601", "PMID:16158191", "PMID:2088646", "Wikipedia:Ganglioside" ; oboInOwl:hasExactSynonym "Ganglioside", "sialoglycosphingolipids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gangliosides" ; oboInOwl:id "CHEBI:28892" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ganglioside" ; rdfs:subClassOf obo:CHEBI_17761, obo:CHEBI_36526 . obo:CHEBI_28918 obo:IAO_0000115 "The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response." ; chebi:charge "0" ; chebi:formula "C9H13NO3" ; chebi:inchi "InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1" ; chebi:inchikey "UCTWMZQNUQWSLP-VIFPVBQESA-N" ; chebi:mass "183.20440" ; chebi:monoisotopicmass "183.08954" ; chebi:smiles "CNC[C@H](O)c1ccc(O)c(O)c1" ; oboInOwl:hasAlternativeId "CHEBI:1942", "CHEBI:23928" ; oboInOwl:hasDbXref "Beilstein:2368277", "CAS:51-43-4", "DrugBank:DB00668", "Drug_Central:1028", "HMDB:HMDB0000068", "KEGG:C00788", "KEGG:D00095", "KNApSAcK:C00029643", "MetaCyc:L-EPINEPHRINE", "PMID:18325983", "PMID:21963816", "PMID:22115931", "PMID:22405854", "PMID:22425731", "PMID:22429969", "PMID:22569014", "PMID:22623754", "PMID:22826982", "PMID:22895980", "PMID:22898765", "PMID:22905594", "PMID:22940899", "PMID:23066296", "PMID:23130169", "PMID:23164182", "PMID:23185846", "PMID:29438107", "Reaxys:2368277", "Wikipedia:Epinephrine" ; oboInOwl:hasExactSynonym "4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-(R)-epinephrine", "(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol", "(-)-adrenaline", "(R)-(-)-Adnephrine", "(R)-(-)-Adrenaline", "(R)-(-)-Epinephrine", "(R)-(-)-Epirenamine", "(R)-(-)-adrenaline", "4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol", "Adrenalin", "Epinephrin", "Epipen", "Epipen JR", "L-Adrenaline", "Primatene", "adrenaline", "epinefrina", "epinephrine", "epinephrinum", "levoepinephrine" ; oboInOwl:id "CHEBI:28918" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-adrenaline" ; rdfs:subClassOf obo:CHEBI_194548, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35522 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35523 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35524 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35569 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35620 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_37886 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50513 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50514 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_71406 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_40751 ] . obo:CHEBI_28938 obo:IAO_0000115 "An onium cation obtained by protonation of ammonia." ; chebi:charge "+1" ; chebi:formula "H4N" ; chebi:inchi "InChI=1S/H3N/h1H3/p+1" ; chebi:inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-O" ; chebi:mass "18.03850" ; chebi:monoisotopicmass "18.03383" ; chebi:smiles "[H][N+]([H])([H])[H]" ; oboInOwl:hasAlternativeId "CHEBI:22534", "CHEBI:49783", "CHEBI:7435" ; oboInOwl:hasDbXref "CAS:14798-03-9", "Gmelin:84", "KEGG:C01342", "MetaCyc:AMMONIUM", "MolBase:929", "PDBeChem:NH4", "PMID:11319011", "PMID:11341317", "PMID:12096804", "PMID:14512268", "PMID:14879753", "PMID:16345391", "PMID:16903292", "PMID:17392693", "PMID:18515490", "PMID:19199063", "PMID:19596600", "PMID:19682559", "PMID:19716251", "PMID:21993530", "PMID:22265469", "PMID:22524020", "PMID:22562341", "PMID:22631217", "Reaxys:16093784", "Wikipedia:Ammonium" ; oboInOwl:hasExactSynonym "ammonium", "azanium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Ammonium(1+)", "NH4(+)", "NH4+", "[NH4](+)", "ammonium cation", "ammonium ion" ; oboInOwl:id "CHEBI:28938" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ammonium" ; rdfs:subClassOf obo:CHEBI_35106, obo:CHEBI_50313, obo:CHEBI_60242, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16134 ] . obo:CHEBI_28940 obo:IAO_0000115 "A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone." ; chebi:charge "0" ; chebi:formula "C27H44O" ; chebi:inchi "InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1" ; chebi:inchikey "QYSXJUFSXHHAJI-YRZJJWOYSA-N" ; chebi:mass "384.63766" ; chebi:monoisotopicmass "384.33922" ; chebi:smiles "[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)C" ; oboInOwl:hasAlternativeId "CHEBI:10008", "CHEBI:23170", "CHEBI:46283" ; oboInOwl:hasDbXref "Beilstein:2339331", "CAS:67-97-0", "DrugBank:DB00169", "Drug_Central:2840", "Gmelin:1267613", "HMDB:HMDB0000876", "KEGG:C05443", "KEGG:D00188", "LIPID_MAPS_instance:LMST03020000", "LIPID_MAPS_instance:LMST03020001", "PDBeChem:VD3", "PMID:10347174", "PMID:11493580", "PMID:12174089", "PMID:12955389", "PMID:15214747", "PMID:15876428", "PMID:16886665", "PMID:17156784", "PMID:184223", "PMID:19817701", "PMID:23964472", "PMID:24304198", "PMID:2838261", "PMID:2997282", "PMID:3494111", "PMID:6265326", "PMID:9627702", "PPDB:160", "Reaxys:2339331", "Wikipedia:Cholecalciferol" ; oboInOwl:hasExactSynonym "(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol", "calciol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-vitamin D3", "(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL", "(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol", "(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol", "CC", "Cholecalciferol", "Delta-D", "Vitamin D3", "activated 7-dehydrocholesterol", "colecalciferol", "oleovitamin D3", "vitamin D3" ; oboInOwl:id "CHEBI:28940" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calciol" ; rdfs:subClassOf obo:CHEBI_26764, obo:CHEBI_35681, obo:CHEBI_36818, obo:CHEBI_36853, obo:CHEBI_73558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_176497 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_28963 obo:IAO_0000115 "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." ; oboInOwl:hasAlternativeId "CHEBI:22481", "CHEBI:22530", "CHEBI:2662" ; oboInOwl:hasDbXref "KEGG:C05383", "PMID:18424273", "PMID:9056391" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aminosugars", "amino sugars", "aminosugar" ; oboInOwl:id "CHEBI:28963" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino sugar" ; rdfs:subClassOf obo:CHEBI_63299 . obo:CHEBI_28965 obo:IAO_0000115 "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." ; chebi:charge "-2" ; chebi:formula "C2O4R" ; chebi:mass "88.019" ; chebi:monoisotopicmass "87.97966" ; chebi:smiles "[O-]C(=O)[*]C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13632", "CHEBI:23688", "CHEBI:23689", "CHEBI:38711" ; oboInOwl:hasExactSynonym "dicarboxylic acid dianion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a dicarboxylate", "dicarboxylate", "dicarboxylates", "dicarboxylic acid dianions" ; oboInOwl:id "CHEBI:28965" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid dianion" ; rdfs:subClassOf obo:CHEBI_35693, obo:CHEBI_38716 . obo:CHEBI_28976 chebi:charge "0" ; chebi:formula "CH2O3" ; chebi:inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)" ; chebi:inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-N" ; chebi:mass "62.02478" ; chebi:monoisotopicmass "62.00039" ; chebi:smiles "OC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:13351", "CHEBI:23017", "CHEBI:23744", "CHEBI:3401" ; oboInOwl:hasDbXref "CAS:463-79-6", "Gmelin:25554", "KEGG:C01353", "PDBeChem:CO3" ; oboInOwl:hasExactSynonym "Carbonic acid", "carbonic acid", "dihydroxidooxidocarbon" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Dihydrogen carbonate", "H2CO3", "Koehlensaeure", "[CO(OH)2]" ; oboInOwl:id "CHEBI:28976" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbonic acid" ; rdfs:subClassOf obo:CHEBI_35605, obo:CHEBI_36961, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17544 ] . obo:CHEBI_29016 obo:IAO_0000115 "An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group." ; chebi:charge "0" ; chebi:formula "C6H14N4O2" ; chebi:inchi "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)" ; chebi:inchikey "ODKSFYDXXFIFQN-UHFFFAOYSA-N" ; chebi:mass "174.20112" ; chebi:monoisotopicmass "174.11168" ; chebi:smiles "NC(CCCNC(N)=N)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:22616", "CHEBI:2643" ; oboInOwl:hasDbXref "Beilstein:1725411", "CAS:7200-25-1", "KEGG:C02385", "PMID:10848923", "Reaxys:1725411", "Wikipedia:L-Arginine" ; oboInOwl:hasExactSynonym "Arginine", "arginine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-5-guanidinovaleric acid", "2-amino-5-(carbamimidamido)pentanoic acid", "2-amino-5-guanidinopentanoic acid", "Arginin", "Harg" ; oboInOwl:id "CHEBI:29016" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "arginine" ; rdfs:subClassOf obo:CHEBI_24436, obo:CHEBI_26167, obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_50340 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32695 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32696 ] . obo:CHEBI_29057 oboInOwl:hasAlternativeId "CHEBI:14490", "CHEBI:24954" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:29057" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "keratan" ; rdfs:subClassOf obo:CHEBI_18085 . obo:CHEBI_29067 obo:IAO_0000115 "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.00950" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13626", "CHEBI:13945", "CHEBI:23026", "CHEBI:58657" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a carboxylate", "carboxylic acid anions", "carboxylic anions" ; oboInOwl:id "CHEBI:29067" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_25696, obo:CHEBI_35406, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33575 ] . obo:CHEBI_29101 obo:IAO_0000115 "A monoatomic monocation obtained from sodium." ; chebi:charge "+1" ; chebi:formula "Na" ; chebi:inchi "InChI=1S/Na/q+1" ; chebi:inchikey "FKNQFGJONOIPTF-UHFFFAOYSA-N" ; chebi:mass "22.98977" ; chebi:monoisotopicmass "22.98922" ; chebi:smiles "[Na+]" ; oboInOwl:hasAlternativeId "CHEBI:26717", "CHEBI:49766", "CHEBI:9175" ; oboInOwl:hasDbXref "CAS:17341-25-2", "Gmelin:15196", "KEGG:C01330", "PDBeChem:NA" ; oboInOwl:hasExactSynonym "sodium cation", "sodium(1+)", "sodium(1+) ion", "sodium(I) cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Na(+)", "Na+", "SODIUM ION" ; oboInOwl:id "CHEBI:29101" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sodium(1+)" ; rdfs:subClassOf obo:CHEBI_25414, obo:CHEBI_33504, obo:CHEBI_37246, obo:CHEBI_60242, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_29103 obo:IAO_0000115 "A monoatomic monocation obtained from potassium." ; chebi:charge "+1" ; chebi:formula "K" ; chebi:inchi "InChI=1S/K/q+1" ; chebi:inchikey "NPYPAHLBTDXSSS-UHFFFAOYSA-N" ; chebi:mass "39.09830" ; chebi:monoisotopicmass "38.96316" ; chebi:smiles "[K+]" ; oboInOwl:hasAlternativeId "CHEBI:26219", "CHEBI:49685", "CHEBI:8345" ; oboInOwl:hasDbXref "CAS:24203-36-9", "Gmelin:15203", "KEGG:C00238", "KEGG:D08403", "PDBeChem:K" ; oboInOwl:hasExactSynonym "potassium cation", "potassium(1+)", "potassium(1+) ion", "potassium(I) cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "K(+)", "K+", "POTASSIUM ION" ; oboInOwl:id "CHEBI:29103" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "potassium(1+)" ; rdfs:subClassOf obo:CHEBI_25414, obo:CHEBI_33504, obo:CHEBI_37247, obo:CHEBI_60242, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_29214 chebi:charge "0" ; chebi:formula "H2O3S" ; chebi:inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)" ; chebi:inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-N" ; chebi:mass "82.08008" ; chebi:monoisotopicmass "81.97247" ; chebi:smiles "[H]S(O)(=O)=O" ; oboInOwl:hasDbXref "Gmelin:1404640" ; oboInOwl:hasExactSynonym "hydridohydroxidodioxidosulfur", "sulfonic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HSHO3", "Sulfonsaeure", "[SHO2(OH)]", "acide sulfonique", "sulphonic acid" ; oboInOwl:id "CHEBI:29214" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfonic acid" ; rdfs:subClassOf obo:CHEBI_33402, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33543 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_48854 ] . obo:CHEBI_29337 chebi:charge "-1" ; chebi:formula "H2N" ; chebi:inchi "InChI=1S/H2N/h1H2/q-1" ; chebi:inchikey "HYGWNUKOUCZBND-UHFFFAOYSA-N" ; chebi:mass "16.02262" ; chebi:monoisotopicmass "16.01927" ; chebi:smiles "[H][N-][H]" ; oboInOwl:hasExactSynonym "amide", "azanide", "dihydridonitrate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "NH2(-)" ; oboInOwl:id "CHEBI:29337" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "azanide" ; rdfs:subClassOf obo:CHEBI_35106, obo:CHEBI_79389, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29340 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16134 ] . obo:CHEBI_29340 obo:IAO_0000115 "A divalent inorganic anion resulting from the removal of two protons from ammonia." ; chebi:charge "-2" ; chebi:formula "HN" ; chebi:inchi "InChI=1S/HN/h1H/q-2" ; chebi:inchikey "DZQYTNGKSBCIOE-UHFFFAOYSA-N" ; chebi:mass "15.01468" ; chebi:monoisotopicmass "15.01200" ; chebi:smiles "[N--][H]" ; oboInOwl:hasExactSynonym "azanediide", "hydridonitrate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "NH(2-)", "imide" ; oboInOwl:id "CHEBI:29340" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydridonitrate(2-)" ; rdfs:subClassOf obo:CHEBI_35106, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29337 ] . obo:CHEBI_29347 obo:IAO_0000115 "A carboxamide derived from a monocarboxylic acid." ; chebi:charge "0" ; chebi:formula "CNOR3" ; chebi:mass "42.01680" ; chebi:monoisotopicmass "41.99799" ; chebi:smiles "[*]N([*])C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13211", "CHEBI:22207", "CHEBI:25383", "CHEBI:6977" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocarboxylic acid amides" ; oboInOwl:id "CHEBI:29347" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocarboxylic acid amide" ; rdfs:subClassOf obo:CHEBI_37622 . obo:CHEBI_29793 chebi:charge "+1" ; chebi:formula "HO2" ; chebi:inchi "InChI=1S/O2/c1-2/p+1" ; chebi:inchikey "MYMOFIZGZYHOMD-UHFFFAOYSA-O" ; chebi:mass "33.00674" ; chebi:monoisotopicmass "32.99711" ; chebi:smiles "[H][O+]=O" ; oboInOwl:hasDbXref "Gmelin:508" ; oboInOwl:hasExactSynonym "dioxidenium", "hydridodioxygen(1+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HO2(+)", "HOO(+)", "[HO2](+)" ; oboInOwl:id "CHEBI:29793" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydridodioxygen(1+)" ; rdfs:subClassOf obo:CHEBI_33693, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15379 ] . obo:CHEBI_29888 obo:IAO_0000115 "An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid." ; chebi:charge "0" ; chebi:formula "H4O7P2" ; chebi:inchi "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)" ; chebi:inchikey "XPPKVPWEQAFLFU-UHFFFAOYSA-N" ; chebi:mass "177.97508" ; chebi:monoisotopicmass "177.94323" ; chebi:smiles "OP(O)(=O)OP(O)(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:45067", "CHEBI:8683" ; oboInOwl:hasDbXref "CAS:2466-09-3", "DrugBank:DB04160", "ECMDB:ECMDB04142", "Gmelin:82619", "KEGG:C00013", "KNApSAcK:C00019561", "PDBeChem:PPV", "PMID:6291941", "Reaxys:3942075" ; oboInOwl:hasExactSynonym "1,5-dihydrido-2,4-dihydroxido-2,4-dioxido-1,3,5-trioxy-2,4-diphosphy-[5]catena", "Diphosphoric acid", "diphosphoric acid", "mu-oxido-bis(dihydroxidooxidophosphorus)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Diphosphorsaeure", "H4P2O7", "PYROPHOSPHATE", "Pyrophosphate", "Pyrophosphoric acid", "Pyrophosphorsaeure", "[(HO)2P(O)OP(O)(OH)2]", "acide diphosphorique" ; oboInOwl:id "CHEBI:29888" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphoric acid" ; rdfs:subClassOf obo:CHEBI_33457, obo:CHEBI_37786, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33017 ] . obo:CHEBI_29922 chebi:charge "0" ; chebi:formula "HO3S" ; chebi:mass "81.07214" ; chebi:monoisotopicmass "80.96464" ; chebi:smiles "S(=O)(O)(*)=O" ; oboInOwl:hasDbXref "PDBeChem:SFO" ; oboInOwl:hasExactSynonym "SULFO GROUP", "hydroxydioxo-lambda(6)-sulfanyl", "hydroxysulfonyl", "sulfo" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-S(O)2(OH)" ; oboInOwl:id "CHEBI:29922" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfo group" ; rdfs:subClassOf obo:CHEBI_33246, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_29214 ] . obo:CHEBI_29985 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group" ; chebi:charge "-1" ; chebi:formula "C5H8NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-M" ; chebi:mass "146.12136" ; chebi:monoisotopicmass "146.04588" ; chebi:smiles "[NH3+][C@@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13107", "CHEBI:21301" ; oboInOwl:hasDbXref "CAS:11070-68-1", "Gmelin:936654", "MetaCyc:GLT" ; oboInOwl:hasExactSynonym "L-glutamate(1-)", "hydrogen L-glutamate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-ammoniopentanedioate", "L-glutamate", "L-glutamic acid monoanion", "L-glutamic acid, ion(1-)" ; oboInOwl:id "CHEBI:29985" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glutamate(1-)" ; rdfs:subClassOf obo:CHEBI_14321, obo:CHEBI_62031, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29988 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16015 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29986 ] . obo:CHEBI_29986 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group" ; chebi:charge "-1" ; chebi:formula "C5H8NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m1/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-M" ; chebi:mass "146.12136" ; chebi:monoisotopicmass "146.04588" ; chebi:smiles "[NH3+][C@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:12979", "CHEBI:21022" ; oboInOwl:hasDbXref "Beilstein:8319427", "MetaCyc:D-GLT" ; oboInOwl:hasExactSynonym "D-glutamate(1-)", "hydrogen D-glutamate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-ammoniopentanedioate", "D-glutamate", "D-glutamic acid monoanion" ; oboInOwl:id "CHEBI:29986" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glutamate(1-)" ; rdfs:subClassOf obo:CHEBI_14321, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29989 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15966 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29985 ] . obo:CHEBI_29987 obo:IAO_0000115 "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)." ; chebi:charge "-2" ; chebi:formula "C5H7NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2" ; chebi:inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-L" ; chebi:mass "145.11342" ; chebi:monoisotopicmass "145.03860" ; chebi:smiles "NC(CCC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4134100", "Gmelin:327903", "Reaxys:4134100" ; oboInOwl:hasExactSynonym "2-aminopentanedioate", "glutamate", "glutamate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutamic acid dianion" ; oboInOwl:id "CHEBI:29987" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutamate(2-)" ; rdfs:subClassOf obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_14321 ] . obo:CHEBI_29988 obo:IAO_0000115 "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid." ; chebi:charge "-2" ; chebi:formula "C5H7NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2/t3-/m0/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-L" ; chebi:mass "145.11342" ; chebi:monoisotopicmass "145.03860" ; chebi:smiles "N[C@@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:327905" ; oboInOwl:hasExactSynonym "(2S)-2-aminopentanedioate", "L-glutamate", "L-glutamate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-glutamic acid dianion" ; oboInOwl:id "CHEBI:29988" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glutamate(2-)" ; rdfs:subClassOf obo:CHEBI_29987, obo:CHEBI_59814, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29985 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29989 ] . obo:CHEBI_29989 chebi:charge "-2" ; chebi:formula "C5H7NO4" ; chebi:inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2/t3-/m1/s1" ; chebi:inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-L" ; chebi:mass "145.11342" ; chebi:monoisotopicmass "145.03860" ; chebi:smiles "N[C@H](CCC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:8143000", "Gmelin:327904" ; oboInOwl:hasExactSynonym "(2R)-2-aminopentanedioate", "D-glutamate", "D-glutamate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-glutamic acid dianion" ; oboInOwl:id "CHEBI:29989" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glutamate(2-)" ; rdfs:subClassOf obo:CHEBI_29987, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29986 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29988 ] . obo:CHEBI_29990 obo:IAO_0000115 "An aspartate(1-) that is the conjugate base of D-aspartic acid." ; chebi:charge "-1" ; chebi:formula "C4H6NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-UWTATZPHSA-M" ; chebi:mass "132.09478" ; chebi:monoisotopicmass "132.03023" ; chebi:smiles "[NH3+][C@H](CC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:12918", "CHEBI:20919" ; oboInOwl:hasDbXref "Beilstein:8316944", "Reaxys:8316944" ; oboInOwl:hasExactSynonym "D-aspartate(1-)", "hydrogen D-aspartate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-ammoniobutanedioate", "(2R)-2-ammoniosuccinate", "D-aspartate", "D-aspartic acid monoanion" ; oboInOwl:id "CHEBI:29990" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-aspartate(1-)" ; rdfs:subClassOf obo:CHEBI_35391, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29994 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17364 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29991 ] . obo:CHEBI_29991 obo:IAO_0000115 "An aspartate(1-) that is the conjugate base of L-aspartic acid." ; chebi:charge "-1" ; chebi:formula "C4H6NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-REOHCLBHSA-M" ; chebi:mass "132.09478" ; chebi:monoisotopicmass "132.03023" ; chebi:smiles "[NH3+][C@@H](CC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13085", "CHEBI:21244" ; oboInOwl:hasDbXref "Gmelin:327374", "Reaxys:15801578" ; oboInOwl:hasExactSynonym "L-aspartate(1-)", "hydrogen L-aspartate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-ammoniobutanedioate", "(2S)-2-ammoniosuccinate", "L-aspartate", "L-aspartic acid monoanion" ; oboInOwl:id "CHEBI:29991" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-aspartate(1-)" ; rdfs:subClassOf obo:CHEBI_35391, obo:CHEBI_59869, obo:CHEBI_62031, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29993 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17053 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29990 ] . obo:CHEBI_29993 obo:IAO_0000115 "An aspartate(2-) that is the conjugate base of L-aspartate(1-)." ; chebi:charge "-2" ; chebi:formula "C4H5NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-REOHCLBHSA-L" ; chebi:mass "131.08684" ; chebi:monoisotopicmass "131.02295" ; chebi:smiles "N[C@@H](CC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4133557", "Gmelin:327367", "Reaxys:4133557" ; oboInOwl:hasExactSynonym "(2S)-2-aminobutanedioate", "L-aspartate", "L-aspartate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-aminosuccinate", "L-aspartic acid dianion" ; oboInOwl:id "CHEBI:29993" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-aspartate(2-)" ; rdfs:subClassOf obo:CHEBI_29995, obo:CHEBI_59814, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29991 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29994 ] . obo:CHEBI_29994 obo:IAO_0000115 "An aspartate(2-) that is the conjugate base of D-aspartate(1-)." ; chebi:charge "-2" ; chebi:formula "C4H5NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-2/t2-/m1/s1" ; chebi:inchikey "CKLJMWTZIZZHCS-UWTATZPHSA-L" ; chebi:mass "131.08684" ; chebi:monoisotopicmass "131.02295" ; chebi:smiles "N[C@H](CC([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:327368", "Reaxys:14495011" ; oboInOwl:hasExactSynonym "(2R)-2-aminobutanedioate", "D-aspartate", "D-aspartate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-aminosuccinate", "D-aspartic acid dianion" ; oboInOwl:id "CHEBI:29994" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-aspartate(2-)" ; rdfs:subClassOf obo:CHEBI_29995, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29990 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_29993 ] . obo:CHEBI_29995 obo:IAO_0000115 "A C4-dicarboxylate that is the dianion obtained by the deprotonation of both the carboxy groups of aspartic acid." ; chebi:charge "-2" ; chebi:formula "C4H5NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-2" ; chebi:inchikey "CKLJMWTZIZZHCS-UHFFFAOYSA-L" ; chebi:mass "131.08684" ; chebi:monoisotopicmass "131.02295" ; chebi:smiles "NC(CC([O-])=O)C([O-])=O" ; oboInOwl:hasExactSynonym "2-aminobutanedioate", "aspartate", "aspartate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-aminosuccinate", "aspartic acid dianion" ; oboInOwl:id "CHEBI:29995" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aspartate(2-)" ; rdfs:subClassOf obo:CHEBI_132943, obo:CHEBI_61336, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35391 ] . obo:CHEBI_30089 obo:IAO_0000115 "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." ; chebi:charge "-1" ; chebi:formula "C2H3O2" ; chebi:inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1" ; chebi:inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-M" ; chebi:mass "59.04402" ; chebi:monoisotopicmass "59.01385" ; chebi:smiles "CC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:13704", "CHEBI:22165", "CHEBI:40480" ; oboInOwl:hasDbXref "Beilstein:1901470", "CAS:71-50-1", "DrugBank:DB03166", "Gmelin:1379", "KEGG:C00033", "MetaCyc:ACET", "PDBeChem:ACT", "PMID:17190852", "PMID:22211106", "PMID:22371380", "Reaxys:1901470", "UM-BBD_compID:c0050", "Wikipedia:Acetate" ; oboInOwl:hasExactSynonym "acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ACETATE ION", "Azetat", "CH3-COO(-)", "Ethanoat", "MeCO2 anion", "acetic acid, ion(1-)", "ethanoate" ; oboInOwl:id "CHEBI:30089" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acetate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15366 ] . obo:CHEBI_30353 chebi:charge "0" ; chebi:formula "C3H7" ; chebi:mass "43.08768" ; chebi:monoisotopicmass "43.05478" ; chebi:smiles "CC(*)C" ; oboInOwl:hasExactSynonym "isopropyl", "propan-2-yl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(CH3)2CH-", "-CH(CH3)2", "1-methylethyl", "iPr", "valine side-chain" ; oboInOwl:id "CHEBI:30353" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isopropyl group" ; rdfs:subClassOf obo:CHEBI_22323, obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_32879 ] . obo:CHEBI_30356 chebi:charge "0" ; chebi:formula "C4H9" ; chebi:mass "57.11426" ; chebi:monoisotopicmass "57.07043" ; chebi:smiles "CC(C)C*" ; oboInOwl:hasExactSynonym "2-methylpropan-1-ido", "2-methylpropyl", "isobutyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(CH3)2CH-CH2-", "-CH2-CH(CH3)2", "iBu", "leucine side-chain" ; oboInOwl:id "CHEBI:30356" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isobutyl group" ; rdfs:subClassOf obo:CHEBI_22323, obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_30363 ] . obo:CHEBI_30363 obo:IAO_0000115 "An alkane that is propane substituted by a methyl group at position 2." ; chebi:charge "0" ; chebi:formula "C4H10" ; chebi:inchi "InChI=1S/C4H10/c1-4(2)3/h4H,1-3H3" ; chebi:inchikey "NNPPMTNAJDCUHE-UHFFFAOYSA-N" ; chebi:mass "58.12220" ; chebi:monoisotopicmass "58.07825" ; chebi:smiles "CC(C)C" ; oboInOwl:hasDbXref "Beilstein:1730720", "CAS:75-28-5", "Gmelin:1301", "KEGG:D04623", "PMID:24179026", "PMID:24464945", "Reaxys:1730720", "Wikipedia:Isobutane" ; oboInOwl:hasExactSynonym "2-methylpropane", "isobutane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(CH3)2CH-CH3", "E943b", "R-600a" ; oboInOwl:id "CHEBI:30363" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isobutane" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_18310, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78433 ] . obo:CHEBI_30411 obo:IAO_0000115 "A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified." ; oboInOwl:hasDbXref "COMe:MOL000036", "PDBeChem:B12", "PMID:11371572", "PMID:15181872" ; oboInOwl:hasExactSynonym "COBALAMIN", "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-cobamide", "cobalamin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:30411" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalamin" ; rdfs:subClassOf obo:CHEBI_23334, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_26348 ] . obo:CHEBI_30413 obo:IAO_0000115 "A heme is any tetrapyrrolic chelate of iron." ; oboInOwl:hasAlternativeId "CHEBI:14386", "CHEBI:24491" ; oboInOwl:hasDbXref "COMe:MOL000025", "DrugBank:DB03014", "KEGG:C00032" ; oboInOwl:hasExactSynonym "heme", "hemes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Haem", "haem", "haeme", "hem", "hemos" ; oboInOwl:id "CHEBI:30413" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heme" ; rdfs:subClassOf obo:CHEBI_25216, obo:CHEBI_33892, obo:CHEBI_33909, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_26348 ] . obo:CHEBI_30566 obo:IAO_0000115 "An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid." ; chebi:charge "-1" ; chebi:formula "C4H8NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)/p-1" ; chebi:inchikey "BTCSSZJGUNDROE-UHFFFAOYSA-M" ; chebi:mass "102.11186" ; chebi:monoisotopicmass "102.05605" ; chebi:smiles "NCCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11961", "CHEBI:20317" ; oboInOwl:hasDbXref "Beilstein:3536873", "Gmelin:559138", "KEGG:C00334", "PMID:12509893", "Reaxys:3536873" ; oboInOwl:hasExactSynonym "4-aminobutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-Amino-butyrat", "4-Aminobutylate", "4-aminobutanoic acid ion (1-)", "4-aminobutyrate", "gamma-aminobutanoate", "gamma-aminobutyrate anion" ; oboInOwl:id "CHEBI:30566" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-aminobutyrate" ; rdfs:subClassOf obo:CHEBI_71666, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17968 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16865 ] . obo:CHEBI_305790 obo:IAO_0000115 "The amino acid zwitterion formed from thyroxine by transfer of a proton from the carboxy group to the amino group. Major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C15H11I4NO4" ; chebi:inchi "InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)" ; chebi:inchikey "XUIIKFGFIJCVMT-UHFFFAOYSA-N" ; chebi:mass "776.87000" ; chebi:monoisotopicmass "776.68669" ; chebi:smiles "[NH3+]C(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O" ; oboInOwl:hasExactSynonym "(2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionate", "thyroxine" ; oboInOwl:id "CHEBI:305790" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thyroxine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_30660 ] . obo:CHEBI_30623 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid." ; chebi:charge "-2" ; chebi:formula "C2O4" ; chebi:inchi "InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2" ; chebi:inchikey "MUBZPKHOEPUJKR-UHFFFAOYSA-L" ; chebi:mass "88.01900" ; chebi:monoisotopicmass "87.98076" ; chebi:smiles "[O-]C(=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14702", "CHEBI:25729", "CHEBI:44820" ; oboInOwl:hasDbXref "Beilstein:1905970", "CAS:338-70-5", "Gmelin:2207", "KEGG:C00209", "PDBeChem:OXL", "Reaxys:1905970", "UM-BBD_compID:c0017" ; oboInOwl:hasExactSynonym "ethanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "OXALATE ION", "ethanedioic acid, ion(2-)", "ox", "oxalate" ; oboInOwl:id "CHEBI:30623" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxalate(2-)" ; rdfs:subClassOf obo:CHEBI_132952, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_46904 ] . obo:CHEBI_30660 obo:IAO_0000115 "An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions." ; chebi:charge "0" ; chebi:formula "C15H11I4NO4" ; chebi:inchi "InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)" ; chebi:inchikey "XUIIKFGFIJCVMT-UHFFFAOYSA-N" ; chebi:mass "776.87006" ; chebi:monoisotopicmass "776.68669" ; chebi:smiles "NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:2228514", "CAS:300-30-1", "PMID:15206581", "PMID:24375501", "PMID:9824273" ; oboInOwl:hasExactSynonym "thyroxine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid", "DL-Thyroxine", "O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine", "Thx" ; oboInOwl:id "CHEBI:30660" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thyroxine" ; rdfs:subClassOf obo:CHEBI_24863, obo:CHEBI_24864, obo:CHEBI_53291, obo:CHEBI_62761, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_52290 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_305790 ] . obo:CHEBI_30661 obo:IAO_0000115 "A tyrosine derivative where the phenolic hydrogen of tyrosine is substituted by 4-hydroxyphenyl." ; chebi:charge "0" ; chebi:formula "C15H15NO4" ; chebi:inchi "InChI=1S/C15H15NO4/c16-14(15(18)19)9-10-1-5-12(6-2-10)20-13-7-3-11(17)4-8-13/h1-8,14,17H,9,16H2,(H,18,19)" ; chebi:inchikey "KKCIOUWDFWQUBT-UHFFFAOYSA-N" ; chebi:mass "273.28394" ; chebi:monoisotopicmass "273.10011" ; chebi:smiles "NC(Cc1ccc(Oc2ccc(O)cc2)cc1)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:2947040", "CAS:1034-10-2", "Gmelin:419747", "PMID:15643926", "Reaxys:2947040" ; oboInOwl:hasExactSynonym "thyronine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid", "O-(4-hydroxyphenyl)-DL-tyrosine" ; oboInOwl:id "CHEBI:30661" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thyronine" ; rdfs:subClassOf obo:CHEBI_33853, obo:CHEBI_62761, obo:CHEBI_83925 . obo:CHEBI_30697 obo:IAO_0000115 "A D-glucosyl group obtained by removing the hydroxy group from the hemiacetal function of beta-D-glucose and, by extension, of a lower oligosaccharide having beta-D-glucose at the reducing end. The unsubstituted parent of the class of beta-D-glucosyl groups." ; chebi:charge "0" ; chebi:formula "C6H11O5" ; chebi:mass "163.14850" ; chebi:monoisotopicmass "163.06065" ; chebi:smiles "[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)*" ; oboInOwl:hasDbXref "PMID:28979944" ; oboInOwl:hasExactSynonym "beta-D-glucopyranosyl", "beta-D-glucosyl group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-D-glucopyranosyl group", "beta-D-glucosyl", "beta-glucopyranosyl group", "beta-glucosyl" ; oboInOwl:id "CHEBI:30697" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-D-glucosyl group" ; rdfs:subClassOf obo:CHEBI_24280, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_15903 ] . obo:CHEBI_30745 obo:IAO_0000115 "A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group." ; chebi:charge "0" ; chebi:formula "C8H8O2" ; chebi:inchi "InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)" ; chebi:inchikey "WLJVXDMOQOGPHL-UHFFFAOYSA-N" ; chebi:mass "136.14792" ; chebi:monoisotopicmass "136.05243" ; chebi:smiles "OC(=O)Cc1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:25977", "CHEBI:44686", "CHEBI:8085" ; oboInOwl:hasDbXref "Beilstein:1099647", "CAS:103-82-2", "Drug_Central:4624", "ECMDB:ECMDB04128", "Gmelin:68976", "HMDB:HMDB0000209", "KEGG:C07086", "KNApSAcK:C00000750", "MetaCyc:PHENYLACETATE", "PDBeChem:PAC", "PMID:12147706", "PMID:12569987", "PMID:15057459", "PMID:15506622", "PMID:15646820", "PMID:17622769", "PMID:2083978", "PMID:24587751", "PMID:24631718", "PMID:7544181", "PMID:7716788", "Reaxys:1099647", "Wikipedia:Phenylacetic_acid", "YMDB:YMDB00891" ; oboInOwl:hasExactSynonym "Phenylacetic acid", "phenylacetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-PHENYLACETIC ACID", "2-Phenylethanoic acid", "Benzeneacetic acid", "Benzylformic acid", "Omega-Phenylacetic acid", "PA", "alpha-toluic acid", "benzeneacetic acid", "omega-phenylacetic acid" ; oboInOwl:id "CHEBI:30745" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylacetic acid" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_25384, obo:CHEBI_25978, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22676 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35219 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50904 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76956 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_90318 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15366 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18401 ] . obo:CHEBI_30751 obo:IAO_0000115 "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." ; chebi:charge "0" ; chebi:formula "CH2O2" ; chebi:inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)" ; chebi:inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-N" ; chebi:mass "46.02538" ; chebi:monoisotopicmass "46.00548" ; chebi:smiles "[H]C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24082", "CHEBI:42460", "CHEBI:5145" ; oboInOwl:hasDbXref "BPDB:1749", "Beilstein:1209246", "CAS:64-18-6", "DrugBank:DB01942", "Gmelin:1008", "HMDB:HMDB0000142", "KEGG:C00058", "KNApSAcK:C00001182", "LIPID_MAPS_instance:LMFA01010040", "MetaCyc:FORMATE", "PDBeChem:FMT", "PMID:12591956", "PMID:14637377", "PMID:15811469", "PMID:16120414", "PMID:16185830", "PMID:16222862", "PMID:16230297", "PMID:16445901", "PMID:16465784", "PMID:18034701", "PMID:18397576", "PMID:22080171", "PMID:22280475", "PMID:22304812", "PMID:22385261", "PMID:22447125", "PMID:22483350", "PMID:22499553", "PMID:22540994", "PMID:22606986", "PMID:22622393", "PMID:3946945", "PMID:7361809", "Patent:CN101481304", "Reaxys:1209246", "Wikipedia:Formic_acid" ; oboInOwl:hasExactSynonym "FORMIC ACID", "Formic acid", "formic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Acide formique", "Ameisensaeure", "H-COOH", "HCO2H", "HCOOH", "Methanoic acid", "aminic acid", "bilorin", "formylic acid", "hydrogen carboxylic acid", "methoic acid" ; oboInOwl:id "CHEBI:30751" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "formic acid" ; rdfs:subClassOf obo:CHEBI_25384, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33282 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_46787 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_48356 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_74783 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15740 ] . obo:CHEBI_30768 obo:IAO_0000115 "A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group." ; chebi:charge "0" ; chebi:formula "C3H6O2" ; chebi:inchi "InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)" ; chebi:inchikey "XBDQKXXYIPTUBI-UHFFFAOYSA-N" ; chebi:mass "74.07850" ; chebi:monoisotopicmass "74.03678" ; chebi:smiles "CCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:26304", "CHEBI:45227", "CHEBI:8476" ; oboInOwl:hasDbXref "Beilstein:506071", "CAS:79-09-4", "DrugBank:DB03766", "Gmelin:1821", "KEGG:C00163", "KEGG:D02310", "LIPID_MAPS_instance:LMFA01010003", "PDBeChem:PPI", "PMID:15868474", "PMID:1628870", "PMID:16763906", "PPDB:1341" ; oboInOwl:hasExactSynonym "Propionic acid", "propanoic acid", "propionic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-CH2-COOH", "PA", "PROPANOIC ACID", "Propanoic acid", "Propionsaeure", "acide propanoique", "acide propionique", "carboxyethane", "ethanecarboxylic acid", "ethylformic acid", "metacetonic acid", "methylacetic acid", "propioic acid", "propoic acid", "pseudoacetic acid" ; oboInOwl:id "CHEBI:30768" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "propionic acid" ; rdfs:subClassOf obo:CHEBI_26607, obo:CHEBI_26666, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_86327 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17272 ] . obo:CHEBI_30769 obo:IAO_0000115 "A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms." ; chebi:charge "0" ; chebi:formula "C6H8O7" ; chebi:inchi "InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)" ; chebi:inchikey "KRKNYBCHXYNGOX-UHFFFAOYSA-N" ; chebi:mass "192.123" ; chebi:monoisotopicmass "192.02700" ; chebi:smiles "OC(=O)CC(O)(CC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:23322", "CHEBI:3727", "CHEBI:41523" ; oboInOwl:hasDbXref "BPDB:1359", "Beilstein:782061", "CAS:77-92-9", "DrugBank:DB04272", "Drug_Central:666", "Gmelin:4240", "HMDB:HMDB0000094", "KEGG:C00158", "KEGG:D00037", "KNApSAcK:C00007619", "MetaCyc:CIT", "PDBeChem:CIT", "PMID:11762832", "PMID:11782123", "PMID:11857437", "PMID:14537820", "PMID:15311880", "PMID:15934243", "PMID:16232627", "PMID:17190852", "PMID:17357118", "PMID:17604395", "PMID:18298573", "PMID:18960216", "PMID:19288211", "PMID:22115968", "PMID:22192423", "PMID:22264346", "PMID:22373571", "PMID:22509852", "Reaxys:782061", "Wikipedia:Citric_Acid" ; oboInOwl:hasExactSynonym "2-hydroxypropane-1,2,3-tricarboxylic acid", "CITRIC ACID", "Citric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Hydroxy-1,2,3-propanetricarboxylic acid", "2-Hydroxytricarballylic acid", "3-Carboxy-3-hydroxypentane-1,5-dioic acid", "Citronensaeure", "E330", "H3cit" ; oboInOwl:id "CHEBI:30769" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citric acid" ; rdfs:subClassOf obo:CHEBI_27093, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33281 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_38161 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_64049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_133748 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35804 ] . obo:CHEBI_30772 obo:IAO_0000115 "A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group." ; chebi:charge "0" ; chebi:formula "C4H8O2" ; chebi:inchi "InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)" ; chebi:inchikey "FERIUCNNQQJTOY-UHFFFAOYSA-N" ; chebi:mass "88.10510" ; chebi:monoisotopicmass "88.05243" ; chebi:smiles "CCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:113450", "CHEBI:22948", "CHEBI:3234", "CHEBI:41208" ; oboInOwl:hasDbXref "Beilstein:906770", "CAS:107-92-6", "DrugBank:DB03568", "Gmelin:26242", "HMDB:HMDB0000039", "KEGG:C00246", "KNApSAcK:C00001180", "LIPID_MAPS_instance:LMFA01010004", "MetaCyc:BUTYRIC_ACID", "PDBeChem:BUA", "PMID:10736622", "PMID:10956204", "PMID:11201044", "PMID:11208715", "PMID:11238216", "PMID:11305323", "PMID:12068484", "PMID:13678314", "PMID:14962641", "PMID:1542095", "PMID:15809727", "PMID:15810631", "PMID:15938880", "PMID:19318247", "PMID:19366864", "PMID:19703412", "PMID:21699495", "PMID:22038864", "PMID:22194341", "PMID:22322557", "PMID:22339023", "PMID:22466881", "Reaxys:906770", "Wikipedia:Butyric_acid" ; oboInOwl:hasExactSynonym "Butyric acid", "butanoic acid", "butyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-butanoic acid", "1-butyric acid", "1-propanecarboxylic acid", "4:0", "BUTANOIC ACID", "Butanoate", "Butanoic acid", "Buttersaeure", "C4:0", "CH3-[CH2]2-COOH", "acide butanoique", "acide butyrique", "butanic acid", "butoic acid", "ethylacetic acid", "n-butanoic acid", "n-butyric acid", "propanecarboxylic acid", "propylformic acid" ; oboInOwl:id "CHEBI:30772" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "butyric acid" ; rdfs:subClassOf obo:CHEBI_140601, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_131604 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84087 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17968 ] . obo:CHEBI_30776 obo:IAO_0000115 "A C6, straight-chain saturated fatty acid." ; chebi:charge "0" ; chebi:formula "C6H12O2" ; chebi:inchi "InChI=1S/C6H12O2/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H,7,8)" ; chebi:inchikey "FUZZWVXGSFPDMH-UHFFFAOYSA-N" ; chebi:mass "116.15830" ; chebi:monoisotopicmass "116.08373" ; chebi:smiles "CCCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:24571", "CHEBI:40213", "CHEBI:5702" ; oboInOwl:hasDbXref "Beilstein:773837", "CAS:142-62-1", "ECMDB:ECMDB21229", "Gmelin:185066", "HMDB:HMDB0000535", "KEGG:C01585", "KNApSAcK:C00001218", "LIPID_MAPS_instance:LMFA01010006", "MetaCyc:HEXANOATE", "PDBeChem:6NA", "PMID:10685018", "PMID:1556177", "PMID:24357269", "PMID:24924750", "Reaxys:773837", "Wikipedia:Hexanoic_acid", "YMDB:YMDB01424" ; oboInOwl:hasExactSynonym "HEXANOIC ACID", "Hexanoic acid", "hexanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-hexanoic acid", "1-pentanecarboxylic acid", "6:0", "C6:0", "CH3-[CH2]4-COOH", "Hexanoate", "Hexylic acid", "Pentanecarboxylic acid", "butylacetic acid", "caproic acid", "capronic acid", "hexoic acid", "n-Caproic acid", "n-hexanoic acid", "n-hexoic acid", "n-hexylic acid", "pentiformic acid", "pentylformic acid" ; oboInOwl:id "CHEBI:30776" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexanoic acid" ; rdfs:subClassOf obo:CHEBI_39418, obo:CHEBI_59554, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17120 ] . obo:CHEBI_30794 obo:IAO_0000115 "An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group." ; chebi:charge "0" ; chebi:formula "C3H4O4" ; chebi:inchi "InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)" ; chebi:inchikey "OFOBLEOULBTSOW-UHFFFAOYSA-N" ; chebi:mass "104.06146" ; chebi:monoisotopicmass "104.01096" ; chebi:smiles "OC(=O)CC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:25132", "CHEBI:44060", "CHEBI:6660" ; oboInOwl:hasDbXref "Beilstein:1751370", "CAS:141-82-2", "DrugBank:DB02175", "Gmelin:2550", "HMDB:HMDB0000691", "KEGG:C00383", "KNApSAcK:C00001193", "LIPID_MAPS_instance:LMFA01170041", "MetaCyc:MALONATE", "PDBeChem:MLA", "PMID:22770225", "Reaxys:1751370", "Wikipedia:Malonic_acid" ; oboInOwl:hasExactSynonym "MALONIC ACID", "Malonic acid", "propanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2malo", "HOOC-CH2-COOH", "Propanedioic acid" ; oboInOwl:id "CHEBI:30794" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "malonic acid" ; rdfs:subClassOf obo:CHEBI_28383, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30795 ] . obo:CHEBI_30795 chebi:charge "-1" ; chebi:formula "C3H3O4" ; chebi:inchi "InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)/p-1" ; chebi:inchikey "OFOBLEOULBTSOW-UHFFFAOYSA-M" ; chebi:mass "103.05352" ; chebi:monoisotopicmass "103.00368" ; chebi:smiles "OC(=O)CC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3904186", "Gmelin:324637" ; oboInOwl:hasExactSynonym "carboxyacetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HOOC-CH2-COO(-)", "Hmalo", "Malonic acid, conjugate base" ; oboInOwl:id "CHEBI:30795" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "malonate(1-)" ; rdfs:subClassOf obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15792 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30794 ] . obo:CHEBI_30807 obo:IAO_0000115 "A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C14H27O2" ; chebi:inchi "InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1" ; chebi:inchikey "TUNFSRHWOTWDNC-UHFFFAOYSA-M" ; chebi:mass "227.364" ; chebi:monoisotopicmass "227.20165" ; chebi:smiles "C(CCCCCCCC)CCCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:35292" ; oboInOwl:hasDbXref "Beilstein:3589340", "Gmelin:335122", "KEGG:C06424", "Reaxys:3589340" ; oboInOwl:hasExactSynonym "Tetradecanoate", "tetradecanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-tetradecanecarboxylate", "CH3-[CH2]12-COO(-)", "myristate", "n-tetradecan-1-oate", "n-tetradecoate", "tetradecoate" ; oboInOwl:id "CHEBI:30807" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetradecanoate" ; rdfs:subClassOf obo:CHEBI_57560, obo:CHEBI_58954, obo:CHEBI_76619, obo:CHEBI_76928, obo:CHEBI_78121, obo:CHEBI_83955, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28875 ] . obo:CHEBI_30839 chebi:charge "-1" ; chebi:formula "C5H3N2O4" ; chebi:inchi "InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1" ; chebi:inchikey "PXQPEWDEAKTCGB-UHFFFAOYSA-M" ; chebi:mass "155.08830" ; chebi:monoisotopicmass "155.00983" ; chebi:smiles "[O-]C(=O)c1cc(=O)[nH]c(=O)[nH]1" ; oboInOwl:hasAlternativeId "CHEBI:14698", "CHEBI:25719" ; oboInOwl:hasDbXref "Beilstein:3651747", "CAS:73-97-2", "Gmelin:464718" ; oboInOwl:hasExactSynonym "2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate", "orotate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:30839" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "orotate" ; rdfs:subClassOf obo:CHEBI_38316, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17568 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16742 ] . obo:CHEBI_30848 chebi:charge "-1" ; chebi:formula "C5H3N4O3" ; chebi:mass "167.10248" ; chebi:monoisotopicmass "167.02051" ; oboInOwl:hasAlternativeId "CHEBI:15290" ; oboInOwl:hasDbXref "CAS:3106-08-9" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "7,9-dihydro-1H-purine-2,6,8(3H)-trione, ion(1-)", "uric acid monoanion", "uric acid, ion(1-)" ; oboInOwl:id "CHEBI:30848" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urate(1-)" ; rdfs:subClassOf obo:CHEBI_46818, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27216 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27226 ] . obo:CHEBI_30860 obo:IAO_0000115 "A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group." ; chebi:charge "0" ; chebi:formula "C4H6O4" ; chebi:inchi "InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)" ; chebi:inchikey "ZIYVHBGGAOATLY-UHFFFAOYSA-N" ; chebi:mass "118.08804" ; chebi:monoisotopicmass "118.02661" ; chebi:smiles "CC(C(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:25319", "CHEBI:42270", "CHEBI:6881" ; oboInOwl:hasDbXref "Beilstein:1756084", "CAS:516-05-2", "DrugBank:DB04183", "Gmelin:50008", "HMDB:HMDB0000202", "KEGG:C02170", "LIPID_MAPS_instance:LMFA01170118", "MetaCyc:CPD-546", "PDBeChem:DXX", "PMID:11673368", "PMID:15770414", "PMID:17190852", "PMID:21478039", "PMID:21652239", "PMID:21687976", "PMID:21748409", "PMID:21802231", "PMID:21896502", "PMID:22104738", "PMID:22233538", "PMID:22301932", "PMID:22332180", "PMID:22377700", "PMID:22422209", "PMID:22424943", "PMID:22509143", "PMID:22537172", "PMID:22770225", "Reaxys:1756084", "Wikipedia:Methylmalonic_acid" ; oboInOwl:hasExactSynonym "METHYLMALONIC ACID", "Methylmalonic acid", "methylpropanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,1-Ethanedicarboxylic acid", "2-methylmalonic acid", "Isosuccinic acid", "alpha-methylmalonic acid" ; oboInOwl:id "CHEBI:30860" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylmalonic acid" ; rdfs:subClassOf obo:CHEBI_66873, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30794 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30861 ] . obo:CHEBI_30861 obo:IAO_0000115 "A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of methylmalonic acid." ; chebi:charge "-1" ; chebi:formula "C4H5O4" ; chebi:inchi "InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/p-1" ; chebi:inchikey "ZIYVHBGGAOATLY-UHFFFAOYSA-M" ; chebi:mass "117.08010" ; chebi:monoisotopicmass "117.01933" ; chebi:smiles "CC(C(O)=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:5499681", "Gmelin:142213", "Reaxys:5499681" ; oboInOwl:hasExactSynonym "2-carboxypropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:30861" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylmalonate(1-)" ; rdfs:subClassOf obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17453 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30860 ] . obo:CHEBI_30879 obo:IAO_0000115 "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." ; chebi:charge "0" ; chebi:formula "HOR" ; chebi:mass "17.007" ; chebi:monoisotopicmass "17.00274" ; chebi:smiles "O[*]" ; oboInOwl:hasAlternativeId "CHEBI:13804", "CHEBI:22288", "CHEBI:2553" ; oboInOwl:hasDbXref "KEGG:C00069" ; oboInOwl:hasExactSynonym "Alcohol", "alcohols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an alcohol" ; oboInOwl:id "CHEBI:30879" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alcohol" ; rdfs:subClassOf obo:CHEBI_33822 . obo:CHEBI_30911 chebi:charge "0" ; chebi:formula "C6H14O6" ; chebi:mass "182.172" ; chebi:monoisotopicmass "182.07904" ; oboInOwl:hasAlternativeId "CHEBI:15093", "CHEBI:26724", "CHEBI:26726", "CHEBI:33795", "CHEBI:33796", "CHEBI:9201" ; oboInOwl:hasDbXref "Beilstein:1721909", "Gmelin:83165", "Wikipedia:Sorbitol" ; oboInOwl:hasExactSynonym "glucitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Sorbitol", "gulitol", "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" ; oboInOwl:id "CHEBI:30911" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucitol" ; rdfs:subClassOf obo:CHEBI_24583, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ] . obo:CHEBI_30915 obo:IAO_0000115 "An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle." ; chebi:charge "0" ; chebi:formula "C5H6O5" ; chebi:inchi "InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)" ; chebi:inchikey "KPGXRSRHYNQIFN-UHFFFAOYSA-N" ; chebi:mass "146.09810" ; chebi:monoisotopicmass "146.02152" ; chebi:smiles "OC(=O)CCC(=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:1253", "CHEBI:19749", "CHEBI:40661" ; oboInOwl:hasDbXref "Beilstein:1705689", "CAS:328-50-7", "DrugBank:DB02926", "Gmelin:602480", "HMDB:HMDB0000208", "KEGG:C00026", "KNApSAcK:C00000769", "MetaCyc:2-KETOGLUTARATE", "PDBeChem:AKG", "PMID:17439666", "PMID:18990406", "PMID:20155414", "PMID:20200292", "PMID:20583149", "PMID:20636327", "PMID:21964641", "Reaxys:1705689", "Wikipedia:Alpha-Ketoglutaric_acid" ; oboInOwl:hasExactSynonym "2-oxopentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Ketoglutaric acid", "Oxoglutaric acid", "alpha-Ketoglutaric acid", "alpha-ketoglutaric acid" ; oboInOwl:id "CHEBI:30915" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-oxoglutaric acid" ; rdfs:subClassOf obo:CHEBI_36145, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17859 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30916 ] . obo:CHEBI_30916 obo:IAO_0000115 "A dicarboxylic acid monoanion resulting from selective deprotonation of the 1-carboxy group of 2-oxoglutaric acid." ; chebi:charge "-1" ; chebi:formula "C5H5O5" ; chebi:inchi "InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-1" ; chebi:inchikey "KPGXRSRHYNQIFN-UHFFFAOYSA-M" ; chebi:mass "145.09020" ; chebi:monoisotopicmass "145.01425" ; chebi:smiles "OC(=O)CCC(=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4132418", "Gmelin:2159365", "Reaxys:4132418" ; oboInOwl:hasExactSynonym "4-carboxy-2-oxobutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ketoglutarate" ; oboInOwl:id "CHEBI:30916" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-oxoglutarate(1-)" ; rdfs:subClassOf obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35907 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16810 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30915 ] . obo:CHEBI_30920 obo:IAO_0000115 "A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid." ; chebi:charge "-1" ; chebi:formula "C6H9O5" ; chebi:inchi "InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)/p-1" ; chebi:inchikey "NPOAOTPXWNWTSH-UHFFFAOYSA-M" ; chebi:mass "161.13270" ; chebi:monoisotopicmass "161.04555" ; chebi:smiles "CC(O)(CC(O)=O)CC([O-])=O" ; oboInOwl:hasExactSynonym "4-carboxy-3-hydroxy-3-methylbutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:30920" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy-3-methylglutarate(1-)" ; rdfs:subClassOf obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35907 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17325 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16831 ] . obo:CHEBI_30921 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by deprotonation of both the carboxy groups of glutaric acid." ; chebi:charge "-2" ; chebi:formula "C5H6O4" ; chebi:inchi "InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)/p-2" ; chebi:inchikey "JFCQEDHGNNZCLN-UHFFFAOYSA-L" ; chebi:mass "130.09874" ; chebi:monoisotopicmass "130.02771" ; chebi:smiles "[O-]C(=O)CCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14322", "CHEBI:24327" ; oboInOwl:hasDbXref "Beilstein:3904695", "Gmelin:240388", "Reaxys:3904695" ; oboInOwl:hasExactSynonym "pentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutarate" ; oboInOwl:id "CHEBI:30921" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutarate(2-)" ; rdfs:subClassOf obo:CHEBI_24329, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35907 ] . obo:CHEBI_3098 obo:IAO_0000115 "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." ; oboInOwl:hasDbXref "KEGG:C01558" ; oboInOwl:hasExactSynonym "Bile acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5beta-bile acid", "5beta-bile acids", "Bile salt", "Gallensaeure", "Gallensaeuren", "bile acids" ; oboInOwl:id "CHEBI:3098" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bile acid" ; rdfs:subClassOf obo:CHEBI_138366, obo:CHEBI_24663 . obo:CHEBI_31011 obo:IAO_0000115 "A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals." ; chebi:charge "-1" ; chebi:formula "C5H9O2" ; chebi:inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)/p-1" ; chebi:inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-M" ; chebi:mass "101.12376" ; chebi:monoisotopicmass "101.06080" ; chebi:smiles "CCCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14751", "CHEBI:25890" ; oboInOwl:hasDbXref "Beilstein:3903735", "CAS:10023-74-2", "Gmelin:325619", "PMID:17314444", "PMID:18783570", "Reaxys:3903735" ; oboInOwl:hasExactSynonym "pentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-[CH2]3-COO(-)", "n-propylacetate", "pentanoate", "pentanoic acid, ion(1-)" ; oboInOwl:id "CHEBI:31011" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "valerate" ; rdfs:subClassOf obo:CHEBI_58951, obo:CHEBI_58954, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17418 ] . obo:CHEBI_32439 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of alanine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H6NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/p-1" ; chebi:inchikey "QNAYBMKLOCPYGJ-UHFFFAOYSA-M" ; chebi:mass "88.08528" ; chebi:monoisotopicmass "88.04040" ; chebi:smiles "CC(N)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3903719", "Gmelin:101040" ; oboInOwl:hasExactSynonym "2-aminopropanoate", "alaninate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alanine anion" ; oboInOwl:id "CHEBI:32439" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alaninate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16449 ] . obo:CHEBI_32440 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of alanine." ; chebi:charge "+1" ; chebi:formula "C3H8NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/p+1" ; chebi:inchikey "QNAYBMKLOCPYGJ-UHFFFAOYSA-O" ; chebi:mass "90.10116" ; chebi:monoisotopicmass "90.05495" ; chebi:smiles "CC([NH3+])C(O)=O" ; oboInOwl:hasDbXref "Gmelin:362663" ; oboInOwl:hasExactSynonym "1-carboxyethanaminium", "alaninium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alanine cation" ; oboInOwl:id "CHEBI:32440" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alaninium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16449 ] . obo:CHEBI_32456 obo:IAO_0000115 "A sulfur-containing amino-acid anion that is the conjugate base of cysteine, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H6NO2S" ; chebi:inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p-1" ; chebi:inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-M" ; chebi:mass "120.15128" ; chebi:monoisotopicmass "120.01247" ; chebi:smiles "NC(CS)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4128885", "Gmelin:363235", "Reaxys:4128885" ; oboInOwl:hasExactSynonym "cysteinate(1-)", "hydrogen cysteinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-mercaptopropanoate", "2-amino-3-sulfanylpropanoate", "cys(-)", "cysteine monoanion" ; oboInOwl:id "CHEBI:32456" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteinate(1-)" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_63470, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32457 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15356 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35237 ] . obo:CHEBI_32457 chebi:charge "-2" ; chebi:formula "C3H5NO2S" ; chebi:inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p-2" ; chebi:inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-L" ; chebi:mass "119.14334" ; chebi:monoisotopicmass "119.00520" ; chebi:smiles "NC(C[S-])C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:49990" ; oboInOwl:hasExactSynonym "cysteinate", "cysteinate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-sulfidopropanoate", "cysteine dianion" ; oboInOwl:id "CHEBI:32457" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteinate(2-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32456 ] . obo:CHEBI_32458 chebi:charge "+1" ; chebi:formula "C3H8NO2S" ; chebi:inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p+1" ; chebi:inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-O" ; chebi:mass "122.16716" ; chebi:monoisotopicmass "122.02703" ; chebi:smiles "[NH3+]C(CS)C(O)=O" ; oboInOwl:hasDbXref "Gmelin:325859" ; oboInOwl:hasExactSynonym "1-carboxy-2-sulfanylethanaminium", "cysteinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-mercaptoethanaminium", "H2cys(+)", "cysteine cation" ; oboInOwl:id "CHEBI:32458" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15356 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35237 ] . obo:CHEBI_32504 obo:IAO_0000115 "An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C9H10NO2" ; chebi:inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1" ; chebi:inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-M" ; chebi:mass "164.18120" ; chebi:monoisotopicmass "164.07170" ; chebi:smiles "NC(Cc1ccccc1)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:329083" ; oboInOwl:hasExactSynonym "phenylalaninate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-phenylpropanoate", "phenylalanine anion" ; oboInOwl:id "CHEBI:32504" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylalaninate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_63473, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28044 ] . obo:CHEBI_32505 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C9H12NO2" ; chebi:inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1" ; chebi:inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-O" ; chebi:mass "166.19710" ; chebi:monoisotopicmass "166.08626" ; chebi:smiles "[NH3+]C(Cc1ccccc1)C(O)=O" ; oboInOwl:hasExactSynonym "phenylalaninium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-phenylethanaminium", "phenylalanine cation" ; oboInOwl:id "CHEBI:32505" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenylalaninium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28044 ] . obo:CHEBI_32507 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of glycine, arising from protonation of the amino." ; chebi:charge "+1" ; chebi:formula "C2H6NO2" ; chebi:inchi "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)/p+1" ; chebi:inchikey "DHMQDGOQFOQNFH-UHFFFAOYSA-O" ; chebi:mass "76.07458" ; chebi:monoisotopicmass "76.03930" ; chebi:smiles "[NH3+]CC(O)=O" ; oboInOwl:hasDbXref "Gmelin:323509" ; oboInOwl:hasExactSynonym "glycinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2gly(+)", "NH3(+)-CH2-COOH", "carboxymethanaminium", "glycine cation" ; oboInOwl:id "CHEBI:32507" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15428 ] . obo:CHEBI_32508 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of glycine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C2H4NO2" ; chebi:inchi "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)/p-1" ; chebi:inchikey "DHMQDGOQFOQNFH-UHFFFAOYSA-M" ; chebi:mass "74.05870" ; chebi:monoisotopicmass "74.02475" ; chebi:smiles "NCC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:1852023", "Gmelin:81890", "Reaxys:1852023", "UM-BBD_compID:c0559" ; oboInOwl:hasExactSynonym "glycinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2N-CH2-COO(-)", "aminoacetate", "gly(-)", "glycine anion" ; oboInOwl:id "CHEBI:32508" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15428 ] . obo:CHEBI_32529 chebi:charge "-1" ; chebi:formula "C6H8N3O2" ; chebi:inchi "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p-1" ; chebi:inchikey "HNDVDQJCIGZPNO-UHFFFAOYSA-M" ; chebi:mass "154.14660" ; chebi:monoisotopicmass "154.06220" ; chebi:smiles "NC(Cc1c[nH]cn1)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3959092", "Gmelin:364417" ; oboInOwl:hasExactSynonym "histidinate(1-)", "hydrogen histidinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-(1H-imidazol-4-yl)propanoate", "histidine anion" ; oboInOwl:id "CHEBI:32529" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidinate(1-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32530 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27570 ] . obo:CHEBI_32530 chebi:charge "-2" ; chebi:formula "C6H7N3O2" ; chebi:inchi "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H2,8,9,10,11)/p-2" ; chebi:inchikey "TWRZMXZXJKNOLO-UHFFFAOYSA-L" ; chebi:mass "153.13880" ; chebi:monoisotopicmass "153.05492" ; chebi:smiles "NC(Cc1c[n-]cn1)C([O-])=O" ; oboInOwl:hasExactSynonym "histidinate", "histidinate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-imidazol-1-id-4-ylpropanoate", "histidine dianion" ; oboInOwl:id "CHEBI:32530" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidinate(2-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32529 ] . obo:CHEBI_32531 chebi:charge "+1" ; chebi:formula "C6H10N3O2" ; chebi:inchi "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1" ; chebi:inchikey "HNDVDQJCIGZPNO-UHFFFAOYSA-O" ; chebi:mass "156.16262" ; chebi:monoisotopicmass "156.07675" ; chebi:smiles "[NH3+]C(Cc1c[nH]c[nH+]1)C([O-])=O" ; oboInOwl:hasExactSynonym "histidinium", "histidinium(1+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammonio-3-(1H-imidazol-3-ium-4-yl)propanoate", "histidine monocation" ; oboInOwl:id "CHEBI:32531" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidinium(1+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27570 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32532 ] . obo:CHEBI_32532 chebi:charge "+2" ; chebi:formula "C6H11N3O2" ; chebi:inchi "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+2" ; chebi:inchikey "HNDVDQJCIGZPNO-UHFFFAOYSA-P" ; chebi:mass "157.17056" ; chebi:monoisotopicmass "157.08403" ; chebi:smiles "[NH3+]C(Cc1c[nH]c[nH+]1)C(O)=O" ; oboInOwl:hasDbXref "Gmelin:1151904" ; oboInOwl:hasExactSynonym "histidinediium", "histidinium(2+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-(2-ammonio-2-carboxyethyl)-1H-imidazol-3-ium", "histidine dication" ; oboInOwl:id "CHEBI:32532" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidinium(2+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32531 ] . obo:CHEBI_32563 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of lysine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C6H13N2O2" ; chebi:inchi "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p-1" ; chebi:inchikey "KDXKERNSBIXSRK-UHFFFAOYSA-M" ; chebi:mass "145.17970" ; chebi:monoisotopicmass "145.09825" ; chebi:smiles "NCCCCC(N)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:815095" ; oboInOwl:hasExactSynonym "lysinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,6-diaminohexanoate", "lys(-)", "lysinate(1-)", "lysine anion" ; oboInOwl:id "CHEBI:32563" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lysinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25094 ] . obo:CHEBI_32564 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of lysine, having two cationic amino groups and an anionic carboxy group." ; chebi:charge "+1" ; chebi:formula "C6H15N2O2" ; chebi:inchi "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1" ; chebi:inchikey "KDXKERNSBIXSRK-UHFFFAOYSA-O" ; chebi:mass "147.19558" ; chebi:monoisotopicmass "147.11280" ; chebi:smiles "[NH3+]CCCCC([NH3+])C([O-])=O" ; oboInOwl:hasExactSynonym "lysinium", "lysinium(1+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,6-diammoniohexanoate", "lysine monocation" ; oboInOwl:id "CHEBI:32564" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lysinium(1+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_25094 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32565 ] . obo:CHEBI_32565 obo:IAO_0000115 "An alpha-amino-acid cation obtained by protonation of both amino groups of lysine." ; chebi:charge "+2" ; chebi:formula "C6H16N2O2" ; chebi:inchi "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+2" ; chebi:inchikey "KDXKERNSBIXSRK-UHFFFAOYSA-P" ; chebi:mass "148.20352" ; chebi:monoisotopicmass "148.12008" ; chebi:smiles "[NH3+]CCCCC([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "lysinediium", "lysinium(2+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxypentane-1,5-diaminium", "lysine dication" ; oboInOwl:id "CHEBI:32565" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lysinium(2+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32564 ] . obo:CHEBI_32612 oboInOwl:hasDbXref "Gmelin:101585" ; oboInOwl:hasExactSynonym "isoleucinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ile(-)", "isoleucine anion", "rel-(2R,3R)-2-amino-3-methylpentanoate" ; oboInOwl:id "CHEBI:32612" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isoleucinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_24898 ] . obo:CHEBI_32613 oboInOwl:hasDbXref "Gmelin:1651827" ; oboInOwl:hasExactSynonym "isoleucinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2ile(+)", "isoleucine cation", "rel-(1R,2R)-1-carboxy-2-methylbutan-1-aminium" ; oboInOwl:id "CHEBI:32613" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isoleucinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_24898 ] . obo:CHEBI_32627 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of leucine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C6H12NO2" ; chebi:inchi "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/p-1" ; chebi:inchikey "ROHFNLRQFUQHCH-UHFFFAOYSA-M" ; chebi:mass "130.16502" ; chebi:monoisotopicmass "130.08735" ; chebi:smiles "CC(C)CC(N)C([O-])=O" ; oboInOwl:hasDbXref "Reaxys:5245805" ; oboInOwl:hasExactSynonym "leucinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-4-methylpentanoate", "leu(-)", "leucine anion" ; oboInOwl:id "CHEBI:32627" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "leucinate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_63471, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25017 ] . obo:CHEBI_32628 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of leucine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C6H14NO2" ; chebi:inchi "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/p+1" ; chebi:inchikey "ROHFNLRQFUQHCH-UHFFFAOYSA-O" ; chebi:mass "132.18090" ; chebi:monoisotopicmass "132.10191" ; chebi:smiles "CC(C)CC([NH3+])C(O)=O" ; oboInOwl:hasDbXref "Gmelin:1651836" ; oboInOwl:hasExactSynonym "leucinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-3-methylbutan-1-aminium", "H2leu(+)", "leucine cation" ; oboInOwl:id "CHEBI:32628" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "leucinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_25017 ] . obo:CHEBI_32644 obo:IAO_0000115 "A sulfur-containing amino-acid anion that is the conjugate base of methionine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C5H10NO2S" ; chebi:inchi "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/p-1" ; chebi:inchikey "FFEARJCKVFRZRR-UHFFFAOYSA-M" ; chebi:mass "148.20444" ; chebi:monoisotopicmass "148.04377" ; chebi:smiles "CSCCC(N)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3937270", "Gmelin:326565", "Reaxys:3937270" ; oboInOwl:hasExactSynonym "methioninate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-4-(methylsulfanyl)butanoate", "met(-)", "methionine anion" ; oboInOwl:id "CHEBI:32644" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methioninate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_63470, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16811 ] . obo:CHEBI_32646 obo:IAO_0000115 "A sulfur-containing amino-acid anion that is the conjugate acid of methionine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C5H12NO2S" ; chebi:inchi "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/p+1" ; chebi:inchikey "FFEARJCKVFRZRR-UHFFFAOYSA-O" ; chebi:mass "150.22032" ; chebi:monoisotopicmass "150.05833" ; chebi:smiles "CSCCC([NH3+])C(O)=O" ; oboInOwl:hasDbXref "Gmelin:326567" ; oboInOwl:hasExactSynonym "methioninium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-3-(methylsulfanyl)propan-1-aminium", "H2met(+)", "methionine cation" ; oboInOwl:id "CHEBI:32646" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methioninium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16811 ] . obo:CHEBI_32650 obo:IAO_0000115 "An optically active form of asparaginate having L-configuration." ; chebi:charge "-1" ; chebi:formula "C4H7N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p-1/t2-/m0/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-REOHCLBHSA-M" ; chebi:mass "131.11006" ; chebi:monoisotopicmass "131.04622" ; chebi:smiles "N[C@@H](CC(N)=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:6115348", "Gmelin:327371", "HMDB:HMDB0000168", "Reaxys:6115348" ; oboInOwl:hasExactSynonym "L-asparaginate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2,4-diamino-4-oxobutanoate", "L-asparagine anion" ; oboInOwl:id "CHEBI:32650" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-asparaginate" ; rdfs:subClassOf obo:CHEBI_32660, obo:CHEBI_59814, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17196 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32656 ] . obo:CHEBI_32651 chebi:charge "+1" ; chebi:formula "C4H9N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p+1/t2-/m0/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-REOHCLBHSA-O" ; chebi:mass "133.12594" ; chebi:monoisotopicmass "133.06077" ; chebi:smiles "NC(=O)C[C@H]([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "L-asparaginium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(1S)-3-amino-1-carboxy-3-oxopropan-1-aminium", "L-asparagine cation" ; oboInOwl:id "CHEBI:32651" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-asparaginium" ; rdfs:subClassOf obo:CHEBI_32661, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17196 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32657 ] . obo:CHEBI_32656 chebi:charge "-1" ; chebi:formula "C4H7N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p-1/t2-/m1/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-UWTATZPHSA-M" ; chebi:mass "131.11006" ; chebi:monoisotopicmass "131.04622" ; chebi:smiles "N[C@H](CC(N)=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:533547" ; oboInOwl:hasExactSynonym "D-asparaginate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2,4-diamino-4-oxobutanoate", "D-asparagine anion" ; oboInOwl:id "CHEBI:32656" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-asparaginate" ; rdfs:subClassOf obo:CHEBI_32660, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28159 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32650 ] . obo:CHEBI_32657 chebi:charge "+1" ; chebi:formula "C4H9N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p+1/t2-/m1/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-UWTATZPHSA-O" ; chebi:mass "133.12594" ; chebi:monoisotopicmass "133.06077" ; chebi:smiles "NC(=O)C[C@@H]([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "D-asparaginium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(1R)-3-amino-1-carboxy-3-oxopropan-1-aminium", "D-asparagine cation" ; oboInOwl:id "CHEBI:32657" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-asparaginium" ; rdfs:subClassOf obo:CHEBI_32661, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28159 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32651 ] . obo:CHEBI_32660 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of asparagine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C4H7N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p-1" ; chebi:inchikey "DCXYFEDJOCDNAF-UHFFFAOYSA-M" ; chebi:mass "131.11006" ; chebi:monoisotopicmass "131.04622" ; chebi:smiles "NC(CC(N)=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:327370" ; oboInOwl:hasExactSynonym "asparaginate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,4-diamino-4-oxobutanoate", "asp(-)", "asparagine anion" ; oboInOwl:id "CHEBI:32660" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "asparaginate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22653 ] . obo:CHEBI_32661 chebi:charge "+1" ; chebi:formula "C4H9N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p+1" ; chebi:inchikey "DCXYFEDJOCDNAF-UHFFFAOYSA-O" ; chebi:mass "133.12594" ; chebi:monoisotopicmass "133.06077" ; chebi:smiles "NC(=O)CC([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "asparaginium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-amino-1-carboxy-3-oxopropan-1-aminium", "H2asp(+)", "asparagine cation" ; oboInOwl:id "CHEBI:32661" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "asparaginium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_22653 ] . obo:CHEBI_32678 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of glutamine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C5H9N2O3" ; chebi:inchi "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/p-1" ; chebi:inchikey "ZDXPYRJPNDTMRX-UHFFFAOYSA-M" ; chebi:mass "145.13664" ; chebi:monoisotopicmass "145.06187" ; chebi:smiles "NC(CCC(N)=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:464703" ; oboInOwl:hasExactSynonym "glutaminate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,5-diamino-5-oxopentanoate", "gln(-)", "glutamine anion" ; oboInOwl:id "CHEBI:32678" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutaminate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_28300 ] . obo:CHEBI_32679 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of glutamine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C5H11N2O3" ; chebi:inchi "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/p+1" ; chebi:inchikey "ZDXPYRJPNDTMRX-UHFFFAOYSA-O" ; chebi:mass "147.15252" ; chebi:monoisotopicmass "147.07642" ; chebi:smiles "NC(=O)CCC([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "glutaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-amino-1-carboxy-4-oxobutan-1-aminium", "H2gln(+)", "glutamine cation" ; oboInOwl:id "CHEBI:32679" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutaminium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28300 ] . obo:CHEBI_32695 chebi:charge "-1" ; chebi:formula "C6H13N4O2" ; chebi:inchi "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p-1" ; chebi:inchikey "ODKSFYDXXFIFQN-UHFFFAOYSA-M" ; chebi:mass "173.19318" ; chebi:monoisotopicmass "173.10440" ; chebi:smiles "NC(CCCNC(N)=N)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:603497" ; oboInOwl:hasExactSynonym "argininate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-5-(carbamimidamido)pentanoate", "2-amino-5-guanidinopentanoate", "arg(-)", "arginine anion" ; oboInOwl:id "CHEBI:32695" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "argininate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29016 ] . obo:CHEBI_32696 chebi:charge "+1" ; chebi:formula "C6H15N4O2" ; chebi:inchi "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1" ; chebi:inchikey "ODKSFYDXXFIFQN-UHFFFAOYSA-O" ; chebi:mass "175.20906" ; chebi:monoisotopicmass "175.11895" ; chebi:smiles "NC(=[NH2+])NCCCC([NH3+])C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:1345599" ; oboInOwl:hasExactSynonym "argininium", "argininium(1+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammonio-5-guanidiniopentanoate", "H2arg(+)", "arginine", "arginine monocation" ; oboInOwl:id "CHEBI:32696" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "argininium(1+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29016 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32697 ] . obo:CHEBI_32697 chebi:charge "+2" ; chebi:formula "C6H16N4O2" ; chebi:inchi "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+2" ; chebi:inchikey "ODKSFYDXXFIFQN-UHFFFAOYSA-P" ; chebi:mass "176.21700" ; chebi:monoisotopicmass "176.12623" ; chebi:smiles "NC(=[NH2+])NCCCC([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "argininediium", "argininium(2+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(1-carboxy-4-guanidiniobutyl)ammonium", "H3arg(2+)", "arginine dication" ; oboInOwl:id "CHEBI:32697" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "argininium(2+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32696 ] . obo:CHEBI_32727 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of tryptophan, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C11H11N2O2" ; chebi:inchi "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/p-1" ; chebi:inchikey "QIVBCDIJIAJPQS-UHFFFAOYSA-M" ; chebi:mass "203.21732" ; chebi:monoisotopicmass "203.08260" ; chebi:smiles "NC(Cc1c[nH]c2ccccc12)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4144997", "Gmelin:331342", "Reaxys:4144998" ; oboInOwl:hasExactSynonym "tryptophanate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-(1H-indol-3-yl)propanoate", "trp(-)", "tryptophan anion" ; oboInOwl:id "CHEBI:32727" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptophanate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27897 ] . obo:CHEBI_32728 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of tryptophan, arising from protonation of the alpha-amino group." ; chebi:charge "+1" ; chebi:formula "C11H13N2O2" ; chebi:inchi "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/p+1" ; chebi:inchikey "QIVBCDIJIAJPQS-UHFFFAOYSA-O" ; chebi:mass "205.23320" ; chebi:monoisotopicmass "205.09715" ; chebi:smiles "[NH3+]C(Cc1c[nH]c2ccccc12)C(O)=O" ; oboInOwl:hasExactSynonym "tryptophanium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-(1H-indol-3-yl)ethanaminium", "Htrp(+)", "tryptophan cation" ; oboInOwl:id "CHEBI:32728" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptophanium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27897 ] . obo:CHEBI_32784 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of tyrosine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C9H10NO3" ; chebi:inchi "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/p-1" ; chebi:inchikey "OUYCCCASQSFEME-UHFFFAOYSA-M" ; chebi:mass "180.18064" ; chebi:monoisotopicmass "180.06662" ; chebi:smiles "NC(Cc1ccc(O)cc1)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3548387", "Beilstein:4139515", "Gmelin:329372" ; oboInOwl:hasExactSynonym "hydrogen tyrosinate", "tyrosinate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-(4-hydroxyphenyl)propanoate", "tyrosine anion" ; oboInOwl:id "CHEBI:32784" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tyrosinate(1-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32785 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18186 ] . obo:CHEBI_32785 chebi:charge "-2" ; chebi:formula "C9H9NO3" ; chebi:inchi "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/p-2" ; chebi:inchikey "OUYCCCASQSFEME-UHFFFAOYSA-L" ; chebi:mass "179.17270" ; chebi:monoisotopicmass "179.05934" ; chebi:smiles "NC(Cc1ccc([O-])cc1)C([O-])=O" ; oboInOwl:hasExactSynonym "tyrosinate", "tyrosinate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-(4-oxidophenyl)propanoate", "tyrosine dianion" ; oboInOwl:id "CHEBI:32785" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tyrosinate(2-)" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32784 ] . obo:CHEBI_32786 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of tyrosine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C9H12NO3" ; chebi:inchi "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/p+1" ; chebi:inchikey "OUYCCCASQSFEME-UHFFFAOYSA-O" ; chebi:mass "182.19652" ; chebi:monoisotopicmass "182.08117" ; chebi:smiles "[NH3+]C(Cc1ccc(O)cc1)C(O)=O" ; oboInOwl:hasExactSynonym "tyrosinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-(4-hydroxyphenyl)ethanaminium", "tyrosine cation" ; oboInOwl:id "CHEBI:32786" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tyrosinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18186 ] . obo:CHEBI_32796 obo:IAO_0000115 "The (R)-enantiomer of 2-hydroxyglutaric acid." ; chebi:charge "0" ; chebi:formula "C5H8O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1" ; chebi:inchikey "HWXBTNAVRSUOJR-GSVOUGTGSA-N" ; chebi:mass "148.11402" ; chebi:monoisotopicmass "148.03717" ; chebi:smiles "O[C@H](CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:18651", "CHEBI:310", "CHEBI:339" ; oboInOwl:hasDbXref "Beilstein:1723806", "KEGG:C01087", "KEGG:C02911", "MetaCyc:R-2-HYDROXYGLUTARATE", "Reaxys:1723806" ; oboInOwl:hasExactSynonym "(2R)-2-hydroxypentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-2-Hydroxyglutarate", "(R)-Hydroxyglutarate" ; oboInOwl:id "CHEBI:32796" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-2-hydroxyglutaric acid" ; rdfs:subClassOf obo:CHEBI_17084, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32797 ] . obo:CHEBI_32797 chebi:charge "0" ; chebi:formula "C5H8O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m0/s1" ; chebi:inchikey "HWXBTNAVRSUOJR-VKHMYHEASA-N" ; chebi:mass "148.11402" ; chebi:monoisotopicmass "148.03717" ; chebi:smiles "O[C@@H](CCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:18739", "CHEBI:380" ; oboInOwl:hasDbXref "Beilstein:1723807", "CAS:13095-48-2", "Gmelin:1218919", "KEGG:C03196", "MetaCyc:CPD-381", "Reaxys:1723807" ; oboInOwl:hasExactSynonym "(2S)-2-hydroxypentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-Hydroxyglutarate" ; oboInOwl:id "CHEBI:32797" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-2-hydroxyglutaric acid" ; rdfs:subClassOf obo:CHEBI_17084, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16782 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32796 ] . obo:CHEBI_32816 obo:IAO_0000115 "A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis." ; chebi:charge "0" ; chebi:formula "C3H4O3" ; chebi:inchi "InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)" ; chebi:inchikey "LCTONWCANYUPML-UHFFFAOYSA-N" ; chebi:mass "88.06206" ; chebi:monoisotopicmass "88.01604" ; chebi:smiles "CC(=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:26466", "CHEBI:45253", "CHEBI:8685" ; oboInOwl:hasDbXref "Beilstein:506211", "CAS:127-17-3", "DrugBank:DB00119", "ECMDB:ECMDB00243", "Gmelin:101087", "HMDB:HMDB0000243", "KEGG:C00022", "KNApSAcK:C00001200", "LIPID_MAPS_instance:LMFA01060077", "MetaCyc:PYRUVATE", "PDBeChem:PYR", "PMID:11762589", "PMID:19260671", "PMID:22150460", "PMID:22233273", "PMID:22735334", "PMID:22770225", "Reaxys:506211", "Wikipedia:Pyruvic_acid", "YMDB:YMDB00175" ; oboInOwl:hasExactSynonym "2-oxopropanoic acid", "PYRUVIC ACID", "Pyruvic acid", "pyruvic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Oxopropanoic acid", "2-Oxopropansaeure", "2-Oxopropionsaeure", "2-ketopropionic acid", "2-oxopropanoic acid", "Acetylformic acid", "BTS", "Brenztraubensaeure", "CH3COCOOH", "Pyroracemic acid", "acetylformic acid", "acide pyruvique", "alpha-Oxopropionsaeure", "alpha-ketopropionic acid" ; oboInOwl:id "CHEBI:32816" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyruvic acid" ; rdfs:subClassOf obo:CHEBI_35910, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30768 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15361 ] . obo:CHEBI_32832 chebi:charge "0" ; chebi:formula "C4H8NO3" ; chebi:mass "118.111" ; chebi:monoisotopicmass "118.05042" ; oboInOwl:hasExactSynonym "threoninate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "rel-(2R,3S)-2-amino-3-hydroxybutanoate", "threonine anion" ; oboInOwl:id "CHEBI:32832" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "threoninate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26986 ] . obo:CHEBI_32833 chebi:charge "0" ; chebi:formula "C4H10NO3" ; chebi:mass "120.127" ; chebi:monoisotopicmass "120.06607" ; oboInOwl:hasExactSynonym "threoninium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "rel-(1R,2S)-1-carboxy-2-hydroxypropan-1-aminium", "threonine cation" ; oboInOwl:id "CHEBI:32833" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "threoninium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_26986 ] . obo:CHEBI_32845 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of serine." ; chebi:charge "-1" ; chebi:formula "C3H6NO3" ; chebi:inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/p-1" ; chebi:inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-M" ; chebi:mass "104.08468" ; chebi:monoisotopicmass "104.03532" ; chebi:smiles "NC(CO)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:324692" ; oboInOwl:hasExactSynonym "serinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-hydroxypropanoate", "serine anion" ; oboInOwl:id "CHEBI:32845" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17822 ] . obo:CHEBI_32846 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of serine." ; chebi:charge "+1" ; chebi:formula "C3H8NO3" ; chebi:inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/p+1" ; chebi:inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-O" ; chebi:mass "106.10056" ; chebi:monoisotopicmass "106.04987" ; chebi:smiles "[NH3+]C(CO)C(O)=O" ; oboInOwl:hasDbXref "Gmelin:1925675" ; oboInOwl:hasExactSynonym "serinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-hydroxyethanaminium", "serine cation" ; oboInOwl:id "CHEBI:32846" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17822 ] . obo:CHEBI_32859 chebi:charge "-1" ; chebi:formula "C5H10NO2" ; chebi:inchi "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/p-1" ; chebi:inchikey "KZSNJWFQEVHDMF-UHFFFAOYSA-M" ; chebi:mass "116.13844" ; chebi:monoisotopicmass "116.07170" ; chebi:smiles "CC(C)C(N)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:49876" ; oboInOwl:hasExactSynonym "valinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-3-methylbutanoate", "val(-)", "valine anion" ; oboInOwl:id "CHEBI:32859" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "valinate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_63471, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27266 ] . obo:CHEBI_32860 chebi:charge "+1" ; chebi:formula "C5H12NO2" ; chebi:inchi "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/p+1" ; chebi:inchikey "KZSNJWFQEVHDMF-UHFFFAOYSA-O" ; chebi:mass "118.15432" ; chebi:monoisotopicmass "118.08626" ; chebi:smiles "CC(C)C([NH3+])C(O)=O" ; oboInOwl:hasDbXref "Gmelin:1651060" ; oboInOwl:hasExactSynonym "valinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-carboxy-2-methylpropan-1-aminium", "H2val(+)", "valine cation" ; oboInOwl:id "CHEBI:32860" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "valinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_27266 ] . obo:CHEBI_32862 obo:IAO_0000115 "An optically active form of prolinate having L-configuration." ; chebi:charge "-1" ; chebi:formula "C5H8NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1/t4-/m0/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-M" ; chebi:mass "114.12250" ; chebi:monoisotopicmass "114.05605" ; chebi:smiles "[O-]C(=O)[C@@H]1CCCN1" ; oboInOwl:hasDbXref "Beilstein:4307988", "Gmelin:82610", "Reaxys:4307988" ; oboInOwl:hasExactSynonym "L-prolinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-pyrrolidine-2-carboxylate", "L-proline anion" ; oboInOwl:id "CHEBI:32862" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-prolinate" ; rdfs:subClassOf obo:CHEBI_32871, obo:CHEBI_59814, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17203 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32867 ] . obo:CHEBI_32864 obo:IAO_0000115 "An optically active form of prolinium having L-configuration." ; chebi:charge "+1" ; chebi:formula "C5H10NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1/t4-/m0/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-O" ; chebi:mass "116.13840" ; chebi:monoisotopicmass "116.07060" ; chebi:smiles "OC(=O)[C@@H]1CCC[NH2+]1" ; oboInOwl:hasDbXref "Gmelin:363493" ; oboInOwl:hasExactSynonym "L-prolinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-carboxypyrrolidinium", "L-proline cation" ; oboInOwl:id "CHEBI:32864" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-prolinium" ; rdfs:subClassOf obo:CHEBI_32872, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17203 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32868 ] . obo:CHEBI_32867 obo:IAO_0000115 "An optically active form of prolinate having D-configuration." ; chebi:charge "-1" ; chebi:formula "C5H8NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1/t4-/m1/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-M" ; chebi:mass "114.12250" ; chebi:monoisotopicmass "114.05605" ; chebi:smiles "[O-]C(=O)[C@H]1CCCN1" ; oboInOwl:hasDbXref "Gmelin:533350" ; oboInOwl:hasExactSynonym "D-prolinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-pyrrolidine-2-carboxylate", "D-proline anion" ; oboInOwl:id "CHEBI:32867" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-prolinate" ; rdfs:subClassOf obo:CHEBI_32871, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16313 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32862 ] . obo:CHEBI_32868 obo:IAO_0000115 "An optically active form of prolinium having D-configuration." ; chebi:charge "+1" ; chebi:formula "C5H10NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1/t4-/m1/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-O" ; chebi:mass "116.13840" ; chebi:monoisotopicmass "116.07060" ; chebi:smiles "OC(=O)[C@H]1CCC[NH2+]1" ; oboInOwl:hasDbXref "Gmelin:363492" ; oboInOwl:hasExactSynonym "D-prolinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-carboxypyrrolidinium", "D-proline cation" ; oboInOwl:id "CHEBI:32868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-prolinium" ; rdfs:subClassOf obo:CHEBI_32872, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16313 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_32864 ] . obo:CHEBI_32871 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C5H8NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1" ; chebi:inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-M" ; chebi:mass "114.12256" ; chebi:monoisotopicmass "114.05605" ; chebi:smiles "[O-]C(=O)C1CCCN1" ; oboInOwl:hasDbXref "Beilstein:5387795", "Gmelin:50151", "Reaxys:5387795" ; oboInOwl:hasExactSynonym "prolinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pro(-)", "proline anion", "pyrrolidine-2-carboxylate" ; oboInOwl:id "CHEBI:32871" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prolinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26271 ] . obo:CHEBI_32872 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C5H10NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1" ; chebi:inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-O" ; chebi:mass "116.13840" ; chebi:monoisotopicmass "116.07060" ; chebi:smiles "OC(=O)C1CCC[NH2+]1" ; oboInOwl:hasExactSynonym "prolinium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-carboxypyrrolidinium", "H2pro(+)", "proline cation" ; oboInOwl:id "CHEBI:32872" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prolinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_26271 ] . obo:CHEBI_32876 obo:IAO_0000115 "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." ; chebi:charge "0" ; chebi:formula "NR3" ; chebi:mass "14.00670" ; chebi:monoisotopicmass "14.00307" ; chebi:smiles "[*]N([*])[*]" ; oboInOwl:hasAlternativeId "CHEBI:26879", "CHEBI:9458" ; oboInOwl:hasDbXref "KEGG:C02196" ; oboInOwl:hasExactSynonym "Tertiary amine", "tertiary amines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "R3N", "tertiaeres Amin" ; oboInOwl:id "CHEBI:32876" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tertiary amine" ; rdfs:subClassOf obo:CHEBI_32952, obo:CHEBI_50996 . obo:CHEBI_32877 obo:IAO_0000115 "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." ; chebi:charge "0" ; chebi:formula "H2NR" ; chebi:mass "16.02260" ; chebi:monoisotopicmass "16.01872" ; chebi:smiles "N[*]" ; oboInOwl:hasAlternativeId "CHEBI:26263", "CHEBI:26265", "CHEBI:8407", "CHEBI:8409" ; oboInOwl:hasDbXref "KEGG:C00375", "KEGG:C00893", "KEGG:C02580" ; oboInOwl:hasExactSynonym "Primary amine", "primary amines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Primary monoamine", "R-NH2", "RCH2NH2", "primaeres Amin" ; oboInOwl:id "CHEBI:32877" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary amine" ; rdfs:subClassOf obo:CHEBI_32952, obo:CHEBI_50994 . obo:CHEBI_32879 chebi:charge "0" ; chebi:formula "C3H8" ; chebi:inchi "InChI=1S/C3H8/c1-3-2/h3H2,1-2H3" ; chebi:inchikey "ATUOYWHBWRKTHZ-UHFFFAOYSA-N" ; chebi:mass "44.09562" ; chebi:monoisotopicmass "44.06260" ; chebi:smiles "CCC" ; oboInOwl:hasDbXref "Beilstein:1730718", "CAS:74-98-6", "Gmelin:25044" ; oboInOwl:hasExactSynonym "propane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-CH2-CH3", "E944", "Propan" ; oboInOwl:id "CHEBI:32879" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "propane" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_18310, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78017 ] . obo:CHEBI_32926 obo:IAO_0000115 "A straight-chain alkane carrying 18 carbon atoms." ; chebi:charge "0" ; chebi:formula "C18H38" ; chebi:inchi "InChI=1S/C18H38/c1-3-5-7-9-11-13-15-17-18-16-14-12-10-8-6-4-2/h3-18H2,1-2H3" ; chebi:inchikey "RZJRJXONCZWCBN-UHFFFAOYSA-N" ; chebi:mass "254.49430" ; chebi:monoisotopicmass "254.29735" ; chebi:smiles "CCCCCCCCCCCCCCCCCC" ; oboInOwl:hasDbXref "Beilstein:1740138", "CAS:593-45-3", "Gmelin:263389", "KNApSAcK:C00030879", "PMID:9842728", "Reaxys:1740138" ; oboInOwl:hasExactSynonym "octadecane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-[CH2]16-CH3", "Oktadekan", "n-octadecane" ; oboInOwl:id "CHEBI:32926" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "octadecane" ; rdfs:subClassOf obo:CHEBI_83563, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76969 ] . obo:CHEBI_32952 obo:IAO_0000115 "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." ; oboInOwl:hasAlternativeId "CHEBI:13814", "CHEBI:22474", "CHEBI:2641" ; oboInOwl:hasDbXref "KEGG:C00706" ; oboInOwl:hasExactSynonym "Amine", "amines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Amin", "Substituted amine" ; oboInOwl:id "CHEBI:32952" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amine" ; rdfs:subClassOf obo:CHEBI_50047 . obo:CHEBI_32964 chebi:charge "-1" ; chebi:formula "C5H11N2O2" ; chebi:inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p-1" ; chebi:inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-M" ; chebi:mass "131.15312" ; chebi:monoisotopicmass "131.08260" ; chebi:smiles "NCCCC(N)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11448", "CHEBI:19370" ; oboInOwl:hasDbXref "Gmelin:1242186" ; oboInOwl:hasExactSynonym "2,5-diaminopentanoate", "ornithinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ornithine anion" ; oboInOwl:id "CHEBI:32964" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ornithinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_31011 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18257 ] . obo:CHEBI_32970 obo:IAO_0000115 "A 1,1-diunsubstituted alkanesulfonate that is ethanesulfonate substituted by an amino group at position 2." ; chebi:charge "-1" ; chebi:formula "C2H6NO3S" ; chebi:inchi "InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)/p-1" ; chebi:inchikey "XOAAWQZATWQOTB-UHFFFAOYSA-M" ; chebi:mass "124.13998" ; chebi:monoisotopicmass "124.00739" ; chebi:smiles "NCCS([O-])(=O)=O" ; oboInOwl:hasDbXref "Beilstein:3588289", "Reaxys:3588289" ; oboInOwl:hasExactSynonym "2-aminoethanesulfonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:32970" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-aminoethanesulfonate" ; rdfs:subClassOf obo:CHEBI_62081, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15891 ] . obo:CHEBI_32988 obo:IAO_0000115 "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." ; oboInOwl:hasAlternativeId "CHEBI:22473", "CHEBI:2633" ; oboInOwl:hasDbXref "KEGG:C00241" ; oboInOwl:hasExactSynonym "Amide", "amides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:32988" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amide" ; rdfs:subClassOf obo:CHEBI_51143 . obo:CHEBI_33017 obo:IAO_0000115 "A monovalent inorganic anion obtained by deprotonation of one of the phosphate OH groups in diphosphoric acid." ; chebi:charge "-1" ; chebi:formula "H3O7P2" ; chebi:inchi "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-1" ; chebi:inchikey "XPPKVPWEQAFLFU-UHFFFAOYSA-M" ; chebi:mass "176.96714" ; chebi:monoisotopicmass "176.93595" ; chebi:smiles "OP(O)(=O)OP(O)([O-])=O" ; oboInOwl:hasDbXref "Gmelin:185086" ; oboInOwl:hasExactSynonym "trihydrogen diphosphate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H3P2O7(-)" ; oboInOwl:id "CHEBI:33017" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphate(1-)" ; rdfs:subClassOf obo:CHEBI_35782, obo:CHEBI_79389, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_45212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29888 ] . obo:CHEBI_33019 obo:IAO_0000115 "A trivalent inorganic anion obtained by removal of all three protons from diphosphoric acid." ; chebi:charge "-3" ; chebi:formula "HO7P2" ; chebi:inchi "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3" ; chebi:inchikey "XPPKVPWEQAFLFU-UHFFFAOYSA-K" ; chebi:mass "174.95126" ; chebi:monoisotopicmass "174.92140" ; chebi:smiles "OP([O-])(=O)OP([O-])([O-])=O" ; oboInOwl:hasDbXref "Beilstein:185088" ; oboInOwl:hasExactSynonym "hydrogen diphosphate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HP2O7(3-)", "diphosphate" ; oboInOwl:id "CHEBI:33019" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphate(3-)" ; rdfs:subClassOf obo:CHEBI_35782, obo:CHEBI_79387, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18361 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_45212 ] . obo:CHEBI_33224 obo:IAO_0000115 "A benzopyran consisting of a pyran ring having a benzene ring ortho-fused across positions 2 and 3." ; chebi:charge "0" ; chebi:formula "C9H10O" ; chebi:inchi "InChI=1S/C9H10O/c1-2-6-9-8(4-1)5-3-7-10-9/h1-2,4,6H,3,5,7H2" ; chebi:inchikey "VZWXIQHBIQLMPN-UHFFFAOYSA-N" ; chebi:mass "134.17510" ; chebi:monoisotopicmass "134.07316" ; chebi:smiles "C1COc2ccccc2C1" ; oboInOwl:hasDbXref "Beilstein:116150", "CAS:493-08-3", "Gmelin:122981", "Reaxys:116150" ; oboInOwl:hasExactSynonym "3,4-dihydro-2H-chromene", "chromane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,4-dihydro-2H-1-benzopyran", "3,4-dihydrobenzo[b]pyran", "Chroman" ; oboInOwl:id "CHEBI:33224" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chromane" ; rdfs:subClassOf obo:CHEBI_23230 . obo:CHEBI_33229 obo:IAO_0000115 "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." ; oboInOwl:hasAlternativeId "CHEBI:10004", "CHEBI:27305" ; oboInOwl:hasDbXref "Wikipedia:Vitamin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vitamin", "vitamina", "vitaminas", "vitamine", "vitamines", "vitamins", "vitaminum" ; oboInOwl:id "CHEBI:33229" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin (role)" ; rdfs:subClassOf obo:CHEBI_27027, obo:CHEBI_52206 . obo:CHEBI_33232 obo:IAO_0000115 "Intended use of the molecular entity or part thereof by humans." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33232" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "application" ; rdfs:subClassOf obo:CHEBI_50906 . obo:CHEBI_33233 obo:IAO_0000115 "A particle not known to have substructure." ; oboInOwl:hasExactSynonym "elementary particle" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "elementary particles" ; oboInOwl:id "CHEBI:33233" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fundamental particle" ; rdfs:subClassOf obo:CHEBI_36342 . obo:CHEBI_33234 obo:IAO_0000115 "Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen." ; oboInOwl:hasDbXref "MetaCyc:Vitamin-E", "PMID:33684201", "PMID:33847203", "PMID:33896432", "PMID:34277234", "PMID:34278890", "PMID:7898412", "PMID:7901680", "Wikipedia:Vitamin_E" ; oboInOwl:hasExactSynonym "vitamin E" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vitamin E vitamer", "vitamin E vitamers", "vitamin-E", "vitamins E" ; oboInOwl:id "CHEBI:33234" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vitamin E" ; rdfs:subClassOf obo:CHEBI_23229, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24020 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_78631 ] . obo:CHEBI_33238 obo:IAO_0000115 "A monoatomic entity is a molecular entity consisting of a single atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "atomic entity", "monoatomic entities" ; oboInOwl:id "CHEBI:33238" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic entity" ; rdfs:subClassOf obo:CHEBI_33259 . obo:CHEBI_33240 obo:IAO_0000115 "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." ; oboInOwl:hasExactSynonym "coordination entities", "coordination entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "coordination compounds" ; oboInOwl:id "CHEBI:33240" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "coordination entity" ; rdfs:subClassOf obo:CHEBI_37577 . obo:CHEBI_33241 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxoacid derivatives" ; oboInOwl:id "CHEBI:33241" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxoacid derivative" ; rdfs:subClassOf obo:CHEBI_37577, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_24833 ] . obo:CHEBI_33242 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic hydrides" ; oboInOwl:id "CHEBI:33242" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic hydride" ; rdfs:subClassOf obo:CHEBI_24835, obo:CHEBI_33692 . obo:CHEBI_33245 obo:IAO_0000115 "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic fundamental parents", "organic parent hydrides" ; oboInOwl:id "CHEBI:33245" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic fundamental parent" ; rdfs:subClassOf obo:CHEBI_37175, obo:CHEBI_50860 . obo:CHEBI_33246 obo:IAO_0000115 "Any substituent group which does not contain carbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic groups" ; oboInOwl:id "CHEBI:33246" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic group" ; rdfs:subClassOf obo:CHEBI_24433 . obo:CHEBI_33247 obo:IAO_0000115 "Any substituent group or skeleton containing carbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic groups" ; oboInOwl:id "CHEBI:33247" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic group" ; rdfs:subClassOf obo:CHEBI_24433, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_50860 ] . obo:CHEBI_33248 obo:IAO_0000115 "A univalent group formed by removing a hydrogen atom from a hydrocarbon." ; oboInOwl:hasExactSynonym "hydrocarbyl group", "hydrocarbyl groups" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "groupe hydrocarbyle", "grupo hidrocarbilo", "grupos hidrocarbilo" ; oboInOwl:id "CHEBI:33248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrocarbyl group" ; rdfs:subClassOf obo:CHEBI_33249, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_24632 ] . obo:CHEBI_33249 obo:IAO_0000115 "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." ; oboInOwl:hasExactSynonym "organyl group", "organyl groups" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "groupe organyle", "grupo organilo", "grupos organilo" ; oboInOwl:id "CHEBI:33249" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organyl group" ; rdfs:subClassOf obo:CHEBI_51447 . obo:CHEBI_33250 obo:IAO_0000115 "A chemical entity constituting the smallest component of an element having the chemical properties of the element." ; oboInOwl:hasAlternativeId "CHEBI:22671", "CHEBI:23907" ; oboInOwl:hasExactSynonym "atom" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "atome", "atomo", "atoms", "atomus", "element", "elements" ; oboInOwl:id "CHEBI:33250" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "atom" ; rdfs:subClassOf obo:CHEBI_24431, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_10545 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33252 ] . obo:CHEBI_33252 obo:IAO_0000115 "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." ; oboInOwl:hasExactSynonym "nucleus" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Atomkern", "Kern", "noyau", "noyau atomique", "nuclei", "nucleo", "nucleo atomico", "nucleus atomi" ; oboInOwl:id "CHEBI:33252" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "atomic nucleus" ; rdfs:subClassOf obo:CHEBI_36347, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33253 ] . obo:CHEBI_33253 obo:IAO_0000115 "Heavy nuclear particle: proton or neutron." ; oboInOwl:hasExactSynonym "nucleon" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Nukleon", "Nukleonen", "nucleons" ; oboInOwl:id "CHEBI:33253" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nucleon" ; rdfs:subClassOf obo:CHEBI_36339, obo:CHEBI_36347 . obo:CHEBI_33256 obo:IAO_0000115 "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." ; oboInOwl:hasExactSynonym "primary amide", "primary amides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33256" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary amide" ; rdfs:subClassOf obo:CHEBI_32988 . obo:CHEBI_33259 obo:IAO_0000115 "A molecular entity all atoms of which have the same atomic number." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "homoatomic entity", "homoatomic molecular entities", "homoatomic molecular entity" ; oboInOwl:id "CHEBI:33259" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental molecular entity" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_33261 obo:IAO_0000115 "An organosulfur compound is a compound containing at least one carbon-sulfur bond." ; oboInOwl:hasAlternativeId "CHEBI:23010", "CHEBI:25714" ; oboInOwl:hasDbXref "Wikipedia:Organosulfur_compounds" ; oboInOwl:hasExactSynonym "organosulfur compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organosulfur compounds" ; oboInOwl:id "CHEBI:33261" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organosulfur compound" ; rdfs:subClassOf obo:CHEBI_26835, obo:CHEBI_36962 . obo:CHEBI_33262 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33262" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental oxygen" ; rdfs:subClassOf obo:CHEBI_24835, obo:CHEBI_25806, obo:CHEBI_33259 . obo:CHEBI_33263 chebi:charge "0" ; chebi:formula "O2" ; chebi:mass "31.999" ; chebi:monoisotopicmass "31.98983" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33263" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diatomic oxygen" ; rdfs:subClassOf obo:CHEBI_33262 . obo:CHEBI_33273 obo:IAO_0000115 "An anion consisting of more than one atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyatomic anions" ; oboInOwl:id "CHEBI:33273" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyatomic anion" ; rdfs:subClassOf obo:CHEBI_22563, obo:CHEBI_36358 . obo:CHEBI_33280 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chemical messenger" ; oboInOwl:id "CHEBI:33280" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "molecular messenger" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_33281 obo:IAO_0000115 "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." ; oboInOwl:hasAlternativeId "CHEBI:22582" ; oboInOwl:hasDbXref "PMID:12964249", "PMID:22117953", "PMID:22439833", "PMID:22849268", "PMID:22849276", "PMID:22958833" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Antibiotika", "Antibiotikum", "antibiotic", "antibiotics", "antibiotique", "antimicrobial", "antimicrobial agents", "antimicrobials", "microbicide", "microbicides" ; oboInOwl:id "CHEBI:33281" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antimicrobial agent" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_33282 obo:IAO_0000115 "A substance (or active part thereof) that kills or slows the growth of bacteria." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antibacterial agents", "antibacterials", "bactericide", "bactericides" ; oboInOwl:id "CHEBI:33282" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antibacterial agent" ; rdfs:subClassOf obo:CHEBI_33281 . obo:CHEBI_33284 obo:IAO_0000115 "A nutrient is a food component that an organism uses to survive and grow." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "nutrients" ; oboInOwl:id "CHEBI:33284" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nutrient" ; rdfs:subClassOf obo:CHEBI_78295 . obo:CHEBI_33285 obo:IAO_0000115 "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heteroorganic entities", "organoelement compounds" ; oboInOwl:id "CHEBI:33285" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heteroorganic entity" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_33286 obo:IAO_0000115 "An agrochemical is a substance that is used in agriculture or horticulture." ; oboInOwl:hasDbXref "Wikipedia:Agrochemical" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "agrichemical", "agrichemicals", "agricultural chemicals", "agrochemicals" ; oboInOwl:id "CHEBI:33286" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "agrochemical" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_33287 obo:IAO_0000115 "A fertilizer is any substance that is added to soil or water to assist the growth of plants." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fertiliser", "fertilizers" ; oboInOwl:id "CHEBI:33287" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fertilizer" ; rdfs:subClassOf obo:CHEBI_33286 . obo:CHEBI_33290 obo:IAO_0000115 "A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food material", "food materials", "food role", "foods", "foodstuff", "foodstuffs" ; oboInOwl:id "CHEBI:33290" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food" ; rdfs:subClassOf obo:CHEBI_52211, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_78295 ] . obo:CHEBI_33292 obo:IAO_0000115 "An energy-rich substance that can be transformed with release of usable energy." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33292" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fuel" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_33295 obo:IAO_0000115 "A substance administered to aid diagnosis of a disease." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "diagnostic aid" ; oboInOwl:id "CHEBI:33295" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diagnostic agent" ; rdfs:subClassOf obo:CHEBI_52217 . obo:CHEBI_33296 obo:IAO_0000115 "A molecular entity containing one or more atoms of an alkali metal." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkali metal molecular entities" ; oboInOwl:id "CHEBI:33296" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkali metal molecular entity" ; rdfs:subClassOf obo:CHEBI_33674, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_22314 ] . obo:CHEBI_33300 obo:IAO_0000115 "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." ; oboInOwl:hasExactSynonym "pnictogens" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "group 15 elements", "group V elements", "nitrogenoideos", "nitrogenoides", "pnictogene", "pnictogenes" ; oboInOwl:id "CHEBI:33300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pnictogen" ; rdfs:subClassOf obo:CHEBI_33560 . obo:CHEBI_33302 obo:IAO_0000115 "A p-block molecular entity containing any pnictogen." ; oboInOwl:hasExactSynonym "pnictogen molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pnictogen molecular entities" ; oboInOwl:id "CHEBI:33302" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pnictogen molecular entity" ; rdfs:subClassOf obo:CHEBI_33675, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33300 ] . obo:CHEBI_33303 obo:IAO_0000115 "Any p-block element belonging to the group 16 family of the periodic table." ; oboInOwl:hasDbXref "PMID:17084588" ; oboInOwl:hasExactSynonym "chalcogen", "chalcogens" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chalkogen", "Chalkogene", "anfigeno", "anfigenos", "calcogeno", "calcogenos", "chalcogene", "chalcogenes", "group 16 elements", "group VI elements" ; oboInOwl:id "CHEBI:33303" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcogen" ; rdfs:subClassOf obo:CHEBI_33560 . obo:CHEBI_33304 obo:IAO_0000115 "Any p-block molecular entity containing a chalcogen." ; oboInOwl:hasExactSynonym "chalcogen molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chalcogen compounds", "chalcogen molecular entities" ; oboInOwl:id "CHEBI:33304" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcogen molecular entity" ; rdfs:subClassOf obo:CHEBI_33675, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33303 ] . obo:CHEBI_33306 oboInOwl:hasExactSynonym "group 14 elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbon group element", "carbon group elements", "carbonoides", "cristallogene", "cristallogenes", "group IV elements" ; oboInOwl:id "CHEBI:33306" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon group element atom" ; rdfs:subClassOf obo:CHEBI_33560 . obo:CHEBI_33308 obo:IAO_0000115 "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." ; chebi:charge "0" ; chebi:formula "CO2R2" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[*]C(=O)O[*]" ; oboInOwl:hasAlternativeId "CHEBI:13204", "CHEBI:23028", "CHEBI:3408" ; oboInOwl:hasDbXref "KEGG:C02391", "Wikipedia:Ester" ; oboInOwl:hasExactSynonym "Carboxylic ester", "carboxylic esters" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a carboxylic ester", "carboxylic acid esters" ; oboInOwl:id "CHEBI:33308" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxylic ester" ; rdfs:subClassOf obo:CHEBI_35701, obo:CHEBI_36586 . obo:CHEBI_33318 obo:IAO_0000115 "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." ; oboInOwl:hasExactSynonym "main group elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hauptgruppenelement", "Hauptgruppenelemente", "main group element" ; oboInOwl:id "CHEBI:33318" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "main group element atom" ; rdfs:subClassOf obo:CHEBI_33250 . obo:CHEBI_33340 oboInOwl:hasExactSynonym "group 12 elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "zinc group element", "zinc group elements" ; oboInOwl:id "CHEBI:33340" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "zinc group element atom" ; rdfs:subClassOf obo:CHEBI_33561 . obo:CHEBI_33356 oboInOwl:hasExactSynonym "group 8 elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iron group element", "iron group elements" ; oboInOwl:id "CHEBI:33356" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron group element atom" ; rdfs:subClassOf obo:CHEBI_27081, obo:CHEBI_33561 . obo:CHEBI_33358 oboInOwl:hasExactSynonym "group 9 elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cobalt group element", "cobalt group elements" ; oboInOwl:id "CHEBI:33358" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt group element atom" ; rdfs:subClassOf obo:CHEBI_27081, obo:CHEBI_33561 . obo:CHEBI_33366 oboInOwl:hasExactSynonym "group 11 elements" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "coinage metals", "copper group element", "copper group elements" ; oboInOwl:id "CHEBI:33366" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "copper group element atom" ; rdfs:subClassOf obo:CHEBI_27081, obo:CHEBI_33561 . obo:CHEBI_33402 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxoacids of sulfur", "sulfur oxoacids" ; oboInOwl:id "CHEBI:33402" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur oxoacid" ; rdfs:subClassOf obo:CHEBI_26835, obo:CHEBI_33484 . obo:CHEBI_33405 obo:IAO_0000115 "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." ; oboInOwl:hasExactSynonym "hydracid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydracids" ; oboInOwl:id "CHEBI:33405" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydracid" ; rdfs:subClassOf obo:CHEBI_33608, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_39141 ] . obo:CHEBI_33408 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pnictogen oxoacids" ; oboInOwl:id "CHEBI:33408" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pnictogen oxoacid" ; rdfs:subClassOf obo:CHEBI_24833, obo:CHEBI_33302, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_138103 ] . obo:CHEBI_33424 oboInOwl:hasExactSynonym "sulfur oxoacid derivative" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfur oxoacid derivatives" ; oboInOwl:id "CHEBI:33424" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur oxoacid derivative" ; rdfs:subClassOf obo:CHEBI_26835, obo:CHEBI_33241 . obo:CHEBI_33429 chebi:charge "-1" ; chebi:mass "0.00000" ; chebi:smiles "[*-]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic monoanions" ; oboInOwl:id "CHEBI:33429" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic monoanion" ; rdfs:subClassOf obo:CHEBI_23905, obo:CHEBI_36830 . obo:CHEBI_33431 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33431" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental chlorine" ; rdfs:subClassOf obo:CHEBI_23117, obo:CHEBI_33434 . obo:CHEBI_33432 chebi:charge "0" ; chebi:formula "Cl" ; chebi:mass "35.453" ; chebi:monoisotopicmass "34.96885" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "atomic chlorine" ; oboInOwl:id "CHEBI:33432" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic chlorine" ; rdfs:subClassOf obo:CHEBI_33431, obo:CHEBI_33433 . obo:CHEBI_33433 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoatomic halogens" ; oboInOwl:id "CHEBI:33433" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoatomic halogen" ; rdfs:subClassOf obo:CHEBI_33238 . obo:CHEBI_33434 oboInOwl:hasExactSynonym "elemental halogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "elemental halogens" ; oboInOwl:id "CHEBI:33434" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental halogen" ; rdfs:subClassOf obo:CHEBI_33259 . obo:CHEBI_33452 obo:IAO_0000115 "Arylmethyl groups and derivatives formed by substitution: ArCR2-." ; oboInOwl:hasExactSynonym "benzylic group", "benzylic groups" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "benzylic groups", "groupe benzylique" ; oboInOwl:id "CHEBI:33452" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzylic group" ; rdfs:subClassOf obo:CHEBI_33249 . obo:CHEBI_33457 obo:IAO_0000115 "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." ; oboInOwl:hasExactSynonym "phosphorus oxoacid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Oxosaeure des Phosphors", "oxoacids of phosphorus", "phosphorus oxoacids" ; oboInOwl:id "CHEBI:33457" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphorus oxoacid" ; rdfs:subClassOf obo:CHEBI_33408, obo:CHEBI_36360 . obo:CHEBI_33459 oboInOwl:hasExactSynonym "pnictogen oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pnictogen oxoanions" ; oboInOwl:id "CHEBI:33459" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pnictogen oxoanion" ; rdfs:subClassOf obo:CHEBI_33302, obo:CHEBI_35406 . obo:CHEBI_33461 oboInOwl:hasExactSynonym "phosphorus oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxoanions of phosphorus", "phosphorus oxoanions" ; oboInOwl:id "CHEBI:33461" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphorus oxoanion" ; rdfs:subClassOf obo:CHEBI_24834, obo:CHEBI_26082, obo:CHEBI_33459 . obo:CHEBI_33482 oboInOwl:hasExactSynonym "sulfur oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxoanions of sulfur", "sulfur oxoanions" ; oboInOwl:id "CHEBI:33482" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur oxoanion" ; rdfs:subClassOf obo:CHEBI_26835, obo:CHEBI_33485 . obo:CHEBI_33484 oboInOwl:hasExactSynonym "chalcogen oxoacid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chalcogen oxoacids" ; oboInOwl:id "CHEBI:33484" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcogen oxoacid" ; rdfs:subClassOf obo:CHEBI_24833, obo:CHEBI_33304, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_138103 ] . obo:CHEBI_33485 oboInOwl:hasExactSynonym "chalcogen oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chalcogen oxoanions" ; oboInOwl:id "CHEBI:33485" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcogen oxoanion" ; rdfs:subClassOf obo:CHEBI_33304, obo:CHEBI_35406 . obo:CHEBI_33497 obo:IAO_0000115 "A molecular entity containing one or more atoms of a transition element." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "transition element molecular entities", "transition metal molecular entity" ; oboInOwl:id "CHEBI:33497" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "transition element molecular entity" ; rdfs:subClassOf obo:CHEBI_23367, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_27081 ] . obo:CHEBI_33504 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkali metal cations" ; oboInOwl:id "CHEBI:33504" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkali metal cation" ; rdfs:subClassOf obo:CHEBI_25213 . obo:CHEBI_33515 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "transition element cations", "transition metal cation" ; oboInOwl:id "CHEBI:33515" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "transition element cation" ; rdfs:subClassOf obo:CHEBI_25213 . obo:CHEBI_33521 obo:IAO_0000115 "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." ; oboInOwl:hasAlternativeId "CHEBI:25217", "CHEBI:6788" ; oboInOwl:hasDbXref "KEGG:C00050", "PMID:21784043", "Wikipedia:Metal" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "elemental metal", "elemental metals", "metal element", "metal elements", "metals" ; oboInOwl:id "CHEBI:33521" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metal atom" ; rdfs:subClassOf obo:CHEBI_33250 . obo:CHEBI_33540 chebi:charge "0" ; chebi:formula "H2O3S2" ; chebi:mass "114.146" ; chebi:monoisotopicmass "113.94454" ; oboInOwl:hasExactSynonym "sulfurothioic acid", "thiosulfuric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33540" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thiosulfuric acid" ; rdfs:subClassOf obo:CHEBI_33402, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33541 ] . obo:CHEBI_33541 chebi:charge "0" ; chebi:formula "HO3S2" ; chebi:mass "113.138" ; chebi:monoisotopicmass "112.93671" ; oboInOwl:hasDbXref "KEGG:C00320" ; oboInOwl:hasExactSynonym "hydrogen sulfurothioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HS2O3(-)" ; oboInOwl:id "CHEBI:33541" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thiosulfate(1-)" ; rdfs:subClassOf obo:CHEBI_33482, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16094 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33540 ] . obo:CHEBI_33543 obo:IAO_0000115 "The sulfur oxoanion formed by deprotonation of sulfonic acid." ; chebi:charge "-1" ; chebi:formula "HO3S" ; chebi:inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)/p-1" ; chebi:inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-M" ; chebi:mass "81.07214" ; chebi:monoisotopicmass "80.96519" ; chebi:smiles "[H]S([O-])(=O)=O" ; oboInOwl:hasDbXref "Gmelin:971569" ; oboInOwl:hasExactSynonym "hydridotrioxidosulfate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "SHO3(-)", "[SHO3](-)", "sulfonates" ; oboInOwl:id "CHEBI:33543" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfonate" ; rdfs:subClassOf obo:CHEBI_33482, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_29214 ] . obo:CHEBI_33551 obo:IAO_0000115 "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." ; chebi:charge "0" ; chebi:formula "HO3SR" ; chebi:mass "81.07100" ; chebi:monoisotopicmass "80.96464" ; chebi:smiles "OS([*])(=O)=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organosulfonic acids", "sulfonic acids" ; oboInOwl:id "CHEBI:33551" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organosulfonic acid" ; rdfs:subClassOf obo:CHEBI_33261, obo:CHEBI_33552, obo:CHEBI_64709, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_29922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33249 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33554 ] . obo:CHEBI_33552 oboInOwl:hasExactSynonym "sulfonic acid derivative" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "derivatives of sulfonic acid", "sulfonic acid derivatives" ; oboInOwl:id "CHEBI:33552" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfonic acid derivative" ; rdfs:subClassOf obo:CHEBI_33424, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_29214 ] . obo:CHEBI_33554 obo:IAO_0000115 "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." ; chebi:charge "-1" ; chebi:formula "O3SR" ; chebi:mass "80.064" ; chebi:monoisotopicmass "79.95681" ; chebi:smiles "*S([O-])(=O)=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organosulfonate", "organosulfonate oxoanions", "organosulfonates" ; oboInOwl:id "CHEBI:33554" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organosulfonate oxoanion" ; rdfs:subClassOf obo:CHEBI_25696, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_33543 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33551 ] . obo:CHEBI_33558 obo:IAO_0000115 "An amino-acid anion obtained by deprotonation of any alpha-amino acid." ; oboInOwl:hasExactSynonym "alpha-amino-acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-amino acid anions", "alpha-amino-acid anions" ; oboInOwl:id "CHEBI:33558" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-amino-acid anion" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33704 ] . obo:CHEBI_33559 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "s-block element", "s-block elements" ; oboInOwl:id "CHEBI:33559" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "s-block element atom" ; rdfs:subClassOf obo:CHEBI_33250 . obo:CHEBI_33560 obo:IAO_0000115 "Any main group element atom belonging to the p-block of the periodic table." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "p-block element", "p-block elements" ; oboInOwl:id "CHEBI:33560" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "p-block element atom" ; rdfs:subClassOf obo:CHEBI_33318 . obo:CHEBI_33561 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "d-block element", "d-block elements" ; oboInOwl:id "CHEBI:33561" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "d-block element atom" ; rdfs:subClassOf obo:CHEBI_27081, obo:CHEBI_33521 . obo:CHEBI_33563 obo:IAO_0000115 "Any member of class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent." ; oboInOwl:hasAlternativeId "CHEBI:24393", "CHEBI:5476" ; oboInOwl:hasDbXref "KEGG:C05005", "Wikipedia:Glycolipids" ; oboInOwl:hasExactSynonym "Glycolipid", "glycolipids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33563" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycolipid" ; rdfs:subClassOf obo:CHEBI_35740 . obo:CHEBI_33566 obo:IAO_0000115 "Any compound containing an o-diphenol component." ; chebi:charge "0" ; chebi:formula "C6H2O2R4" ; chebi:mass "106.079" ; chebi:monoisotopicmass "106.00548" ; chebi:smiles "OC1=C(O)C(*)=C(*)C(*)=C1*" ; oboInOwl:hasAlternativeId "CHEBI:134187", "CHEBI:13628", "CHEBI:18862" ; oboInOwl:hasDbXref "KEGG:C15571" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,2-benzenediols", "a catechol", "benzene-1,2-diols" ; oboInOwl:id "CHEBI:33566" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "catechols" ; rdfs:subClassOf obo:CHEBI_33570 . obo:CHEBI_33567 obo:IAO_0000115 "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." ; chebi:charge "0" ; chebi:formula "C8H9NO2R2" ; chebi:mass "151.163" ; chebi:monoisotopicmass "151.06333" ; oboInOwl:hasAlternativeId "CHEBI:23056", "CHEBI:3468" ; oboInOwl:hasDbXref "KEGG:C02012" ; oboInOwl:hasExactSynonym "Catecholamine", "catecholamines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "catecholamines" ; oboInOwl:id "CHEBI:33567" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "catecholamine" ; rdfs:subClassOf obo:CHEBI_25375, obo:CHEBI_33566, obo:CHEBI_64365 . obo:CHEBI_33568 obo:IAO_0000115 "A racemate comprising equimolar amounts of (R)-adrenaline and (S)-adrenaline." ; chebi:charge "0" ; chebi:formula "C9H13NO3" ; chebi:mass "183.207" ; chebi:monoisotopicmass "183.08954" ; oboInOwl:hasDbXref "Beilstein:2212160", "CAS:329-65-7", "Drug_Central:4508", "Gmelin:51559", "LINCS:LSM-4958", "PMID:10052027", "PMID:24252294", "PMID:24719616", "Reaxys:2212160" ; oboInOwl:hasExactSynonym "rac-4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+-)-adrenaline", "(+-)-epinephrine", "2-(methylamino)-1-(3,4-dihydroxyphenyl)ethanol", "dl-adrenaline", "epinephrine racemic", "rac-adrenaline", "racemic adrenaline", "racepinefrina", "racepinefrine", "racepinefrinum" ; oboInOwl:id "CHEBI:33568" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "adrenaline" ; rdfs:subClassOf obo:CHEBI_60911, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_28918 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_40751 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_33569 obo:IAO_0000115 "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." ; chebi:charge "0" ; chebi:formula "C8H11NO3" ; chebi:inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2" ; chebi:inchikey "SFLSHLFXELFNJZ-UHFFFAOYSA-N" ; chebi:mass "169.17788" ; chebi:monoisotopicmass "169.07389" ; chebi:smiles "NCC(O)c1ccc(O)c(O)c1" ; oboInOwl:hasDbXref "Beilstein:2210994", "CAS:138-65-8", "Gmelin:863925", "LINCS:LSM-5181" ; oboInOwl:hasExactSynonym "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "noradrenalina", "norepinephrine" ; oboInOwl:id "CHEBI:33569" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "noradrenaline" ; rdfs:subClassOf obo:CHEBI_33567, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_166902 ] . obo:CHEBI_33570 oboInOwl:hasAlternativeId "CHEBI:22705", "CHEBI:22711" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33570" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzenediols" ; rdfs:subClassOf obo:CHEBI_33853 . obo:CHEBI_33575 obo:IAO_0000115 "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." ; chebi:charge "0" ; chebi:formula "CHO2R" ; chebi:mass "45.01740" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "OC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13428", "CHEBI:13627", "CHEBI:23027" ; oboInOwl:hasDbXref "PMID:17147560", "PMID:18433345", "Wikipedia:Carboxylic_acid" ; oboInOwl:hasExactSynonym "carboxylic acid", "carboxylic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Carbonsaeure", "Carbonsaeuren", "Karbonsaeure", "RC(=O)OH", "acide carboxylique", "acides carboxyliques", "acido carboxilico", "acidos carboxilicos" ; oboInOwl:id "CHEBI:33575" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxylic acid" ; rdfs:subClassOf obo:CHEBI_35605, obo:CHEBI_36586, obo:CHEBI_64709, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_46883 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29067 ] . obo:CHEBI_33576 obo:IAO_0000115 "Any carboxylic acid having a sulfur substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "S-containing carboxylic acid", "S-containing carboxylic acids", "sulfur-containing carboxylic acids" ; oboInOwl:id "CHEBI:33576" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur-containing carboxylic acid" ; rdfs:subClassOf obo:CHEBI_33261, obo:CHEBI_33575 . obo:CHEBI_33579 obo:IAO_0000115 "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "main group compounds", "main group molecular entities" ; oboInOwl:id "CHEBI:33579" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "main group molecular entity" ; rdfs:subClassOf obo:CHEBI_23367, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33318 ] . obo:CHEBI_33582 oboInOwl:hasExactSynonym "carbon group molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbon group molecular entities" ; oboInOwl:id "CHEBI:33582" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon group molecular entity" ; rdfs:subClassOf obo:CHEBI_33675, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33306 ] . obo:CHEBI_33595 obo:IAO_0000115 "Any molecule that consists of a series of atoms joined together to form a ring." ; oboInOwl:hasDbXref "Wikipedia:Cyclic_compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic compounds" ; oboInOwl:id "CHEBI:33595" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic compound" ; rdfs:subClassOf obo:CHEBI_25367 . obo:CHEBI_33597 obo:IAO_0000115 "A cyclic compound having as ring members atoms of the same element only." ; oboInOwl:hasExactSynonym "homocyclic compound", "homocyclic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "isocyclic compounds" ; oboInOwl:id "CHEBI:33597" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homocyclic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_33598 obo:IAO_0000115 "A homocyclic compound in which all of the ring members are carbon atoms." ; oboInOwl:hasExactSynonym "carbocyclic compound", "carbocyclic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbocycle" ; oboInOwl:id "CHEBI:33598" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbocyclic compound" ; rdfs:subClassOf obo:CHEBI_33597, obo:CHEBI_33832 . obo:CHEBI_33608 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydrogen compounds", "hydrogen molecular entities" ; oboInOwl:id "CHEBI:33608" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogen molecular entity" ; rdfs:subClassOf obo:CHEBI_33674, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_49637 ] . obo:CHEBI_33635 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polycyclic compounds" ; oboInOwl:id "CHEBI:33635" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polycyclic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_33636 obo:IAO_0000115 "A molecule that features two fused rings." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "bicyclic compounds" ; oboInOwl:id "CHEBI:33636" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bicyclic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_33653 obo:IAO_0000115 "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." ; oboInOwl:hasExactSynonym "aliphatic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33653" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aliphatic compound" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_33655 obo:IAO_0000115 "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." ; oboInOwl:hasExactSynonym "aromatic compounds", "aromatic molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatics", "aromatische Verbindungen" ; oboInOwl:id "CHEBI:33655" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_33658 obo:IAO_0000115 "Any monocyclic or polycyclic aromatic hydrocarbon." ; oboInOwl:hasExactSynonym "arene", "arenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatic hydrocarbons" ; oboInOwl:id "CHEBI:33658" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "arene" ; rdfs:subClassOf obo:CHEBI_33659, obo:CHEBI_33663 . obo:CHEBI_33659 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic aromatic compounds" ; oboInOwl:id "CHEBI:33659" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic aromatic compound" ; rdfs:subClassOf obo:CHEBI_33655, obo:CHEBI_33832 . obo:CHEBI_33661 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocyclic compounds" ; oboInOwl:id "CHEBI:33661" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocyclic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_33662 obo:IAO_0000115 "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." ; oboInOwl:hasExactSynonym "annulene", "annulenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33662" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "annulene" ; rdfs:subClassOf obo:CHEBI_33664 . obo:CHEBI_33663 oboInOwl:hasExactSynonym "cyclic hydrocarbon" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic hydrocarbons" ; oboInOwl:id "CHEBI:33663" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic hydrocarbon" ; rdfs:subClassOf obo:CHEBI_24632, obo:CHEBI_33598 . obo:CHEBI_33664 oboInOwl:hasExactSynonym "monocyclic hydrocarbon", "monocyclic hydrocarbons" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocyclic hydrocarbons" ; oboInOwl:id "CHEBI:33664" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocyclic hydrocarbon" ; rdfs:subClassOf obo:CHEBI_33663 . obo:CHEBI_33670 oboInOwl:hasExactSynonym "heteromonocyclic compound", "heteromonocyclic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33670" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heteromonocyclic compound" ; rdfs:subClassOf obo:CHEBI_33661, obo:CHEBI_5686 . obo:CHEBI_33671 obo:IAO_0000115 "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." ; oboInOwl:hasExactSynonym "heteropolycyclic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyheterocyclic compounds" ; oboInOwl:id "CHEBI:33671" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heteropolycyclic compound" ; rdfs:subClassOf obo:CHEBI_33635, obo:CHEBI_5686 . obo:CHEBI_33672 obo:IAO_0000115 "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." ; oboInOwl:hasExactSynonym "heterobicyclic compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33672" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heterobicyclic compound" ; rdfs:subClassOf obo:CHEBI_33636, obo:CHEBI_5686 . obo:CHEBI_33674 obo:IAO_0000115 "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." ; oboInOwl:hasExactSynonym "s-block molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "s-block compounds", "s-block molecular entities" ; oboInOwl:id "CHEBI:33674" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "s-block molecular entity" ; rdfs:subClassOf obo:CHEBI_33579, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33559 ] . obo:CHEBI_33675 obo:IAO_0000115 "A main group molecular entity that contains one or more atoms of a p-block element." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "p-block compounds", "p-block molecular entities", "p-block molecular entitiy" ; oboInOwl:id "CHEBI:33675" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "p-block molecular entity" ; rdfs:subClassOf obo:CHEBI_33579, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33560 ] . obo:CHEBI_33676 obo:IAO_0000115 "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." ; oboInOwl:hasExactSynonym "d-block molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "d-block compounds", "d-block molecular entities" ; oboInOwl:id "CHEBI:33676" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "d-block molecular entity" ; rdfs:subClassOf obo:CHEBI_33497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33561 ] . obo:CHEBI_33692 obo:IAO_0000115 "Hydrides are chemical compounds of hydrogen with other chemical elements." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33692" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrides" ; rdfs:subClassOf obo:CHEBI_33608, obo:CHEBI_37577 . obo:CHEBI_33693 oboInOwl:hasExactSynonym "oxygen hydride" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydrides of oxygen", "oxygen hydrides" ; oboInOwl:id "CHEBI:33693" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxygen hydride" ; rdfs:subClassOf obo:CHEBI_36902 . obo:CHEBI_33694 obo:IAO_0000115 "A macromolecule formed by a living organism." ; oboInOwl:hasExactSynonym "biopolymer" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Biopolymere", "biomacromolecules", "biopolymers" ; oboInOwl:id "CHEBI:33694" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biomacromolecule" ; rdfs:subClassOf obo:CHEBI_33839, obo:CHEBI_50860 . obo:CHEBI_33695 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "genetically encoded biomacromolecules", "genetically encoded biopolymers", "information biomacromolecules", "information biopolymers", "information macromolecule", "information macromolecules" ; oboInOwl:id "CHEBI:33695" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "information biomacromolecule" ; rdfs:subClassOf obo:CHEBI_33694 . obo:CHEBI_33700 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "canonical amino-acid residue", "canonical amino-acid residues", "common amino acid residues", "proteinogenic amino-acid residues", "standard amino acid residues", "standard amino-acid residues" ; oboInOwl:id "CHEBI:33700" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proteinogenic amino-acid residue" ; rdfs:subClassOf obo:CHEBI_33710 . obo:CHEBI_33702 obo:IAO_0000115 "A cation consisting of more than one atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyatomic cations" ; oboInOwl:id "CHEBI:33702" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyatomic cation" ; rdfs:subClassOf obo:CHEBI_36358, obo:CHEBI_36916 . obo:CHEBI_33703 oboInOwl:hasExactSynonym "amino-acid cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino acid cation", "amino-acid cations" ; oboInOwl:id "CHEBI:33703" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino-acid cation" ; rdfs:subClassOf obo:CHEBI_33702 . obo:CHEBI_33704 obo:IAO_0000115 "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.05870" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "NC([*])C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:10208", "CHEBI:13779", "CHEBI:22442", "CHEBI:2642" ; oboInOwl:hasDbXref "KEGG:C00045", "KEGG:C05167" ; oboInOwl:hasExactSynonym "alpha-amino acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Amino acid", "Amino acids", "alpha-amino acids", "alpha-amino carboxylic acids" ; oboInOwl:id "CHEBI:33704" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33558 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_78608 ] . obo:CHEBI_33706 obo:IAO_0000115 "A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position beta to the carboxy group." ; oboInOwl:hasExactSynonym "beta-amino acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-amino acids" ; oboInOwl:id "CHEBI:33706" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-amino acid" ; rdfs:subClassOf obo:CHEBI_83820 . obo:CHEBI_33707 obo:IAO_0000115 "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group." ; oboInOwl:hasExactSynonym "gamma-amino acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gamma-amino acids" ; oboInOwl:id "CHEBI:33707" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-amino acid" ; rdfs:subClassOf obo:CHEBI_83820, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_71666 ] . obo:CHEBI_33708 obo:IAO_0000115 "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." ; oboInOwl:hasExactSynonym "amino-acid residue" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino acid residue", "amino-acid residues" ; oboInOwl:id "CHEBI:33708" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino-acid residue" ; rdfs:subClassOf obo:CHEBI_33247, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_33709 ] . obo:CHEBI_33709 obo:IAO_0000115 "A carboxylic acid containing one or more amino groups." ; oboInOwl:hasAlternativeId "CHEBI:13815", "CHEBI:22477" ; oboInOwl:hasDbXref "Wikipedia:Amino_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aminocarbonsaeure", "Aminokarbonsaeure", "Aminosaeure", "amino acids" ; oboInOwl:id "CHEBI:33709" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_50047, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_37022 ] . obo:CHEBI_33710 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-amino-acid residues" ; oboInOwl:id "CHEBI:33710" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-amino-acid residue" ; rdfs:subClassOf obo:CHEBI_33708, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_33704 ] . obo:CHEBI_33719 oboInOwl:hasExactSynonym "alpha-amino-acid cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-amino acid cations", "alpha-amino-acid cations" ; oboInOwl:id "CHEBI:33719" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-amino-acid cation" ; rdfs:subClassOf obo:CHEBI_33703 . obo:CHEBI_33720 oboInOwl:hasExactSynonym "carbohydrate acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate acids" ; oboInOwl:id "CHEBI:33720" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate acid" ; rdfs:subClassOf obo:CHEBI_16646, obo:CHEBI_33575, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33721 ] . obo:CHEBI_33721 oboInOwl:hasExactSynonym "carbohydrate acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate acid anions" ; oboInOwl:id "CHEBI:33721" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33720 ] . obo:CHEBI_33729 oboInOwl:hasExactSynonym "tetritol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tetritols" ; oboInOwl:id "CHEBI:33729" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetritol" ; rdfs:subClassOf obo:CHEBI_17522 . obo:CHEBI_33744 oboInOwl:hasExactSynonym "iron group molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iron group molecular entities" ; oboInOwl:id "CHEBI:33744" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron group molecular entity" ; rdfs:subClassOf obo:CHEBI_33497, obo:CHEBI_33676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33356 ] . obo:CHEBI_33752 obo:IAO_0000115 "Any aldonic acid formed by oxidising the aldehyde group of an aldohexose to a carboxylic acid group." ; oboInOwl:hasExactSynonym "hexonic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldohexonic acids", "hexonic acids" ; oboInOwl:id "CHEBI:33752" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexonic acid" ; rdfs:subClassOf obo:CHEBI_22301 . obo:CHEBI_33760 oboInOwl:hasExactSynonym "hexonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldohexonates", "hexonates" ; oboInOwl:id "CHEBI:33760" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexonate" ; rdfs:subClassOf obo:CHEBI_22299 . obo:CHEBI_33767 oboInOwl:hasExactSynonym "cobalt group molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cobalt group molecular entities" ; oboInOwl:id "CHEBI:33767" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt group molecular entity" ; rdfs:subClassOf obo:CHEBI_33497, obo:CHEBI_33676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33358 ] . obo:CHEBI_33778 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:33778" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "galactonates" ; rdfs:subClassOf obo:CHEBI_33760 . obo:CHEBI_33822 obo:IAO_0000115 "An organic compound having at least one hydroxy group attached to a carbon atom." ; oboInOwl:hasAlternativeId "CHEBI:64710" ; oboInOwl:hasExactSynonym "hydroxy compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic alcohol", "organic hydroxy compounds" ; oboInOwl:id "CHEBI:33822" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic hydroxy compound" ; rdfs:subClassOf obo:CHEBI_24651, obo:CHEBI_50860 . obo:CHEBI_33832 obo:IAO_0000115 "Any organic molecule that consists of atoms connected in the form of a ring." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic cyclic compounds" ; oboInOwl:id "CHEBI:33832" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic cyclic compound" ; rdfs:subClassOf obo:CHEBI_33595, obo:CHEBI_72695 . obo:CHEBI_33833 obo:IAO_0000115 "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." ; oboInOwl:hasExactSynonym "heteroarenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hetarenes" ; oboInOwl:id "CHEBI:33833" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heteroarene" ; rdfs:subClassOf obo:CHEBI_24532, obo:CHEBI_33659 . obo:CHEBI_33836 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "benzenoid aromatic compounds", "benzenoid compound" ; oboInOwl:id "CHEBI:33836" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "benzenoid aromatic compound" ; rdfs:subClassOf obo:CHEBI_33598, obo:CHEBI_33659 . obo:CHEBI_33837 obo:IAO_0000115 "Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion." ; oboInOwl:hasDbXref "COMe:PRX000001" ; oboInOwl:hasExactSynonym "conjugated proteins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "complex protein" ; oboInOwl:id "CHEBI:33837" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "conjugated protein" ; rdfs:subClassOf obo:CHEBI_36080 . obo:CHEBI_33839 obo:IAO_0000115 "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasDbXref "Wikipedia:Macromolecule" ; oboInOwl:hasExactSynonym "macromolecule" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "macromolecules", "polymer", "polymer molecule", "polymers" ; oboInOwl:id "CHEBI:33839" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "macromolecule" ; rdfs:subClassOf obo:CHEBI_36357 . obo:CHEBI_33842 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatic annulenes" ; oboInOwl:id "CHEBI:33842" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic annulene" ; rdfs:subClassOf obo:CHEBI_33662, obo:CHEBI_33847 . obo:CHEBI_33847 obo:IAO_0000115 "A monocyclic aromatic hydrocarbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocyclic arenes" ; oboInOwl:id "CHEBI:33847" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocyclic arene" ; rdfs:subClassOf obo:CHEBI_33658 . obo:CHEBI_33853 obo:IAO_0000115 "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." ; chebi:charge "0" ; chebi:formula "C6HOR5" ; chebi:mass "89.072" ; chebi:monoisotopicmass "89.00274" ; chebi:smiles "C1(=C(C(=C(C(=C1*)*)*)*)*)O" ; oboInOwl:hasAlternativeId "CHEBI:13664", "CHEBI:13825", "CHEBI:25969", "CHEBI:2857" ; oboInOwl:hasDbXref "KEGG:C15584", "MetaCyc:Phenols", "Wikipedia:Phenols" ; oboInOwl:hasExactSynonym "phenols" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aryl alcohol", "a phenol", "arenols" ; oboInOwl:id "CHEBI:33853" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phenols" ; rdfs:subClassOf obo:CHEBI_33659, obo:CHEBI_33822 . obo:CHEBI_33856 obo:IAO_0000115 "An amino acid whose structure includes an aromatic ring." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "88.085" ; chebi:monoisotopicmass "74.02420" ; oboInOwl:hasAlternativeId "CHEBI:13820", "CHEBI:22623", "CHEBI:2835" ; oboInOwl:hasDbXref "KEGG:C01021", "Wikipedia:Aromatic_amino_acid" ; oboInOwl:hasExactSynonym "Aromatic amino acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatic amino acids" ; oboInOwl:id "CHEBI:33856" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic amino acid" ; rdfs:subClassOf obo:CHEBI_33659, obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63473 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_76042 ] . obo:CHEBI_33859 obo:IAO_0000115 "Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring." ; oboInOwl:hasAlternativeId "CHEBI:13817", "CHEBI:13821", "CHEBI:2830" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatic carboxylic acids" ; oboInOwl:id "CHEBI:33859" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic carboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_33659, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_91007 ] . obo:CHEBI_33861 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "transition element coordination entities", "transition metal coordination compounds", "transition metal coordination entities" ; oboInOwl:id "CHEBI:33861" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "transition element coordination entity" ; rdfs:subClassOf obo:CHEBI_33240, obo:CHEBI_33497 . obo:CHEBI_33888 oboInOwl:hasExactSynonym "cobalt molecular entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cobalt compounds", "cobalt molecular entities" ; oboInOwl:id "CHEBI:33888" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt molecular entity" ; rdfs:subClassOf obo:CHEBI_33767, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_27638 ] . obo:CHEBI_33890 oboInOwl:hasExactSynonym "cobalt coordination entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cobalt coordination compounds", "cobalt coordination entities" ; oboInOwl:id "CHEBI:33890" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt coordination entity" ; rdfs:subClassOf obo:CHEBI_33861, obo:CHEBI_33888 . obo:CHEBI_33892 oboInOwl:hasExactSynonym "iron coordination entity" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iron coordination compounds", "iron coordination entities" ; oboInOwl:id "CHEBI:33892" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron coordination entity" ; rdfs:subClassOf obo:CHEBI_24873, obo:CHEBI_33861 . obo:CHEBI_33893 obo:IAO_0000115 "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." ; oboInOwl:hasExactSynonym "reagent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "reactif", "reactivo", "reagents" ; oboInOwl:id "CHEBI:33893" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "reagent" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_33906 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cobalt corrinoids", "cobalt-corrinoids" ; oboInOwl:id "CHEBI:33906" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cobalt corrinoid" ; rdfs:subClassOf obo:CHEBI_33890, obo:CHEBI_33909, obo:CHEBI_33913 . obo:CHEBI_33909 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "metal-tetrapyrrole", "metal-tetrapyrrole complex", "metallotetrapyrroles" ; oboInOwl:id "CHEBI:33909" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metallotetrapyrrole" ; rdfs:subClassOf obo:CHEBI_36309 . obo:CHEBI_33913 obo:IAO_0000115 "A derivative of the corrin nucleus, which contains four reduced or partly reduced pyrrole rings joined in a macrocycle by three =C- groups and one direct carbon-carbon bond linking alpha positions." ; chebi:charge "0" ; chebi:formula "C19HN4R21" ; chebi:mass "285.239" ; chebi:monoisotopicmass "285.02012" ; oboInOwl:hasAlternativeId "CHEBI:23391", "CHEBI:3890" ; oboInOwl:hasDbXref "KEGG:C06021" ; oboInOwl:hasExactSynonym "Corrinoid", "corrinoid", "corrinoids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Corrinoid protein", "Corrinoid protein Co+", "Korrinoid", "corrinoide", "corrinoides" ; oboInOwl:id "CHEBI:33913" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "corrinoid" ; rdfs:subClassOf obo:CHEBI_36309, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ] . obo:CHEBI_33916 obo:IAO_0000115 "A pentose with a (potential) aldehyde group at one end." ; oboInOwl:hasDbXref "PMID:10723607" ; oboInOwl:hasExactSynonym "aldopentose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldopentoses" ; oboInOwl:id "CHEBI:33916" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldopentose" ; rdfs:subClassOf obo:CHEBI_15693, obo:CHEBI_25901 . obo:CHEBI_33917 obo:IAO_0000115 "A hexose with a (potential) aldehyde group at one end." ; oboInOwl:hasAlternativeId "CHEBI:2558" ; oboInOwl:hasExactSynonym "aldohexose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldohexoses" ; oboInOwl:id "CHEBI:33917" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldohexose" ; rdfs:subClassOf obo:CHEBI_15693, obo:CHEBI_18133 . obo:CHEBI_33937 obo:IAO_0000115 "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "macronutrients" ; oboInOwl:id "CHEBI:33937" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "macronutrient" ; rdfs:subClassOf obo:CHEBI_33284 . obo:CHEBI_33942 obo:IAO_0000115 "Any aldopentose where the open-chain form has all the hydroxy groups on the same side in the Fischer projection. Occurrs in two enantiomeric forms, D- and L-ribose, of which only the former is found in nature." ; chebi:charge "0" ; chebi:formula "C5H10O5" ; chebi:mass "150.130" ; chebi:monoisotopicmass "150.05282" ; oboInOwl:hasAlternativeId "CHEBI:26564" ; oboInOwl:hasExactSynonym "ribo-pentose", "ribose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Rib" ; oboInOwl:id "CHEBI:33942" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ribose" ; rdfs:subClassOf obo:CHEBI_33916 . obo:CHEBI_33984 obo:IAO_0000115 "Any deoxygalactose that is deoxygenated at the 6-position." ; oboInOwl:hasAlternativeId "CHEBI:24118", "CHEBI:5182" ; oboInOwl:hasDbXref "CAS:7724-73-4", "KEGG:C00382", "PMID:12651883" ; oboInOwl:hasExactSynonym "6-deoxygalactose", "Fucose", "fucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "6-Deoxygalactose", "Fuc" ; oboInOwl:id "CHEBI:33984" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fucose" ; rdfs:subClassOf obo:CHEBI_18133, obo:CHEBI_23622 . obo:CHEBI_3424 obo:IAO_0000115 "A quaternary ammonium ion that is the the conjugate acid of carnitine." ; chebi:charge "+1" ; chebi:formula "C7H16NO3" ; chebi:inchi "InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/p+1" ; chebi:inchikey "PHIQHXFUZVPYII-UHFFFAOYSA-O" ; chebi:mass "162.20688" ; chebi:monoisotopicmass "162.11247" ; chebi:smiles "C[N+](C)(C)CC(O)CC(O)=O" ; oboInOwl:hasDbXref "CAS:406-76-8", "CAS:461-06-3", "KEGG:C00487" ; oboInOwl:hasExactSynonym "3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy-4-(trimethylammonio)butanoic acid", "Carnitine" ; oboInOwl:id "CHEBI:3424" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carnitinium" ; rdfs:subClassOf obo:CHEBI_35267, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16080 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17126 ] . obo:CHEBI_350546 obo:IAO_0000115 "An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "C10H13N2O" ; chebi:inchi "InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1" ; chebi:inchikey "QZAYGJVTTNCVMB-UHFFFAOYSA-O" ; chebi:mass "177.22250" ; chebi:monoisotopicmass "177.10224" ; chebi:smiles "[NH3+]CCc1c[nH]c2ccc(O)cc12" ; oboInOwl:hasExactSynonym "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "serotonin", "serotonin cation" ; oboInOwl:id "CHEBI:350546" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serotonin(1+)" ; rdfs:subClassOf obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28790 ] . obo:CHEBI_35106 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "nitrogen hydrides" ; oboInOwl:id "CHEBI:35106" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nitrogen hydride" ; rdfs:subClassOf obo:CHEBI_35881, obo:CHEBI_51143 . obo:CHEBI_35107 obo:IAO_0000115 "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "azanes" ; oboInOwl:id "CHEBI:35107" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "azane" ; rdfs:subClassOf obo:CHEBI_35106 . obo:CHEBI_35134 oboInOwl:hasDbXref "COMe:PRX000002" ; oboInOwl:hasExactSynonym "metalloprotein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "metalloproteine", "metalloproteins" ; oboInOwl:id "CHEBI:35134" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metalloprotein" ; rdfs:subClassOf obo:CHEBI_33837 . obo:CHEBI_35136 oboInOwl:hasDbXref "COMe:PRX000004" ; oboInOwl:hasExactSynonym "iron protein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iron proteins", "iron-containing proteins" ; oboInOwl:id "CHEBI:35136" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iron protein" ; rdfs:subClassOf obo:CHEBI_35134 . obo:CHEBI_35137 obo:IAO_0000115 "Conjugated proteins containing heme as the prosthetic group." ; oboInOwl:hasDbXref "COMe:PRX000008" ; oboInOwl:hasExactSynonym "hemoprotein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Haemoprotein", "Haemprotein", "haem protein", "haemoprotein", "heme protein", "hemeproteins", "hemoproteins" ; oboInOwl:id "CHEBI:35137" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hemoprotein" ; rdfs:subClassOf obo:CHEBI_35136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_30413 ] . obo:CHEBI_35143 oboInOwl:hasDbXref "COMe:PRX000321" ; oboInOwl:hasExactSynonym "hemoglobin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "haemoglobin", "vertebrate haemoglobin" ; oboInOwl:id "CHEBI:35143" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hemoglobin" ; rdfs:subClassOf obo:CHEBI_5386 . obo:CHEBI_35147 chebi:charge "0" ; chebi:formula "C40H56" ; chebi:inchi "InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+/t37-/m0/s1" ; chebi:inchikey "ANVAOWXLWRTKGA-NTXLUARGSA-N" ; chebi:mass "536.87264" ; chebi:monoisotopicmass "536.43820" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\[C@H]1C(C)=CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C" ; oboInOwl:hasDbXref "Beilstein:2067409", "CAS:7488-99-5", "LIPID_MAPS_instance:LMPR01070011" ; oboInOwl:hasExactSynonym "(6'R)-beta,epsilon-carotene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-alpha-carotene", "alpha-carotene (natural)" ; oboInOwl:id "CHEBI:35147" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(6'R)-beta,epsilon-carotene" ; rdfs:subClassOf obo:CHEBI_28425, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_35148 ] . obo:CHEBI_35148 chebi:charge "0" ; chebi:formula "C40H56" ; chebi:inchi "InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+/t37-/m1/s1" ; chebi:inchikey "ANVAOWXLWRTKGA-QTRZAOAUSA-N" ; chebi:mass "536.87264" ; chebi:monoisotopicmass "536.43820" ; chebi:smiles "CC(\\C=C\\C=C(C)\\C=C\\[C@@H]1C(C)=CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C" ; oboInOwl:hasDbXref "Beilstein:2682045" ; oboInOwl:hasExactSynonym "(6'S)-beta,epsilon-carotene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35148" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(6'S)-beta,epsilon-carotene" ; rdfs:subClassOf obo:CHEBI_28425, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_35147 ] . obo:CHEBI_35163 oboInOwl:hasExactSynonym "cyclic carotene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic carotenes" ; oboInOwl:id "CHEBI:35163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic carotene" ; rdfs:subClassOf obo:CHEBI_23042 . obo:CHEBI_35179 obo:IAO_0000115 "An oxo monocarboxylic acid anion in which the oxo group is located at the 2-position." ; chebi:charge "-1" ; chebi:formula "C2O3R" ; chebi:mass "72.020" ; chebi:monoisotopicmass "71.98474" ; chebi:smiles "[O-]C(=O)C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:70795" ; oboInOwl:hasDbXref "MetaCyc:2-Oxo-carboxylates", "PMID:10850983" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-oxo monocarboxylate", "2-oxo monocarboxylic acid anions", "a 2-oxocarboxylate" ; oboInOwl:id "CHEBI:35179" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-oxo monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_35902, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35910 ] . obo:CHEBI_35186 obo:IAO_0000115 "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]." ; oboInOwl:hasExactSynonym "terpene", "terpenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Terpen", "terpenes", "terpeno", "terpenos" ; oboInOwl:id "CHEBI:35186" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "terpene" ; rdfs:subClassOf obo:CHEBI_24632, obo:CHEBI_24913 . obo:CHEBI_35190 obo:IAO_0000115 "A C20 terpene." ; oboInOwl:hasExactSynonym "diterpenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Diterpen", "diterpenes", "diterpeno", "diterpenos" ; oboInOwl:id "CHEBI:35190" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diterpene" ; rdfs:subClassOf obo:CHEBI_35186 . obo:CHEBI_35191 obo:IAO_0000115 "A C30 terpene." ; oboInOwl:hasExactSynonym "triterpenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Triterpen", "triterpenes", "triterpeno", "triterpenos" ; oboInOwl:id "CHEBI:35191" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "triterpene" ; rdfs:subClassOf obo:CHEBI_35186 . obo:CHEBI_35193 obo:IAO_0000115 "A C40 terpene." ; oboInOwl:hasExactSynonym "tetraterpenes" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tetraterpenes", "tetraterpeno", "tetraterpenos" ; oboInOwl:id "CHEBI:35193" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetraterpene" ; rdfs:subClassOf obo:CHEBI_35186 . obo:CHEBI_35195 obo:IAO_0000115 "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces." ; oboInOwl:hasExactSynonym "surfactant" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "surface active agent", "surfactants" ; oboInOwl:id "CHEBI:35195" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "surfactant" ; rdfs:subClassOf obo:CHEBI_63046 . obo:CHEBI_35219 oboInOwl:hasAlternativeId "CHEBI:26154", "CHEBI:26156" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "plant growth inhibitor", "plant growth inhibitors", "plant growth retardants" ; oboInOwl:id "CHEBI:35219" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "plant growth retardant" ; rdfs:subClassOf obo:CHEBI_26155 . obo:CHEBI_35221 obo:IAO_0000115 "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." ; oboInOwl:hasDbXref "Wikipedia:Antimetabolite" ; oboInOwl:hasExactSynonym "antimetabolite" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antimetabolites" ; oboInOwl:id "CHEBI:35221" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antimetabolite" ; rdfs:subClassOf obo:CHEBI_52206 . obo:CHEBI_35222 obo:IAO_0000115 "A substance that diminishes the rate of a chemical reaction." ; oboInOwl:hasExactSynonym "inhibitor" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inhibidor", "inhibiteur", "inhibitors" ; oboInOwl:id "CHEBI:35222" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inhibitor" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_35223 obo:IAO_0000115 "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." ; oboInOwl:hasExactSynonym "catalyst" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Katalysator", "catalizador", "catalyseur" ; oboInOwl:id "CHEBI:35223" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "catalyst" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_35237 chebi:charge "0" ; chebi:formula "C3H7NO2S" ; chebi:inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)" ; chebi:inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-N" ; chebi:mass "121.15922" ; chebi:monoisotopicmass "121.01975" ; chebi:smiles "[NH3+]C(CS)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:49992" ; oboInOwl:hasExactSynonym "2-ammonio-3-sulfanylpropanoate", "cysteine zwitterion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)H3N-CH(CH2SH)-COO(-)", "2-ammonio-3-mercaptopropanoate" ; oboInOwl:id "CHEBI:35237" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cysteine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_32456 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_32458 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15356 ] . obo:CHEBI_35238 obo:IAO_0000115 "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." ; oboInOwl:hasExactSynonym "amino acid zwitterion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35238" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino acid zwitterion" ; rdfs:subClassOf obo:CHEBI_27369 . obo:CHEBI_35243 obo:IAO_0000115 "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of serine." ; chebi:charge "0" ; chebi:formula "C3H7NO3" ; chebi:inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)" ; chebi:inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-N" ; chebi:mass "105.09262" ; chebi:monoisotopicmass "105.04259" ; chebi:smiles "[NH3+]C(CO)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3935647", "Gmelin:2060272" ; oboInOwl:hasExactSynonym "2-ammonio-3-hydroxypropanoate", "serine zwitterion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35243" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "serine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17822 ] . obo:CHEBI_35267 obo:IAO_0000115 "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." ; chebi:charge "+1" ; chebi:formula "NR4" ; chebi:mass "14.00670" ; chebi:monoisotopicmass "14.00307" ; chebi:smiles "[*][N+]([*])([*])[*]" ; oboInOwl:hasAlternativeId "CHEBI:26470", "CHEBI:8693" ; oboInOwl:hasDbXref "KEGG:C06703" ; oboInOwl:hasExactSynonym "quaternary ammonium ion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Quaternary amine", "a quaternary ammonium", "quaternary ammonium ions" ; oboInOwl:id "CHEBI:35267" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "quaternary ammonium ion" ; rdfs:subClassOf obo:CHEBI_25697, obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_28938 ] . obo:CHEBI_35274 obo:IAO_0000115 "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ammonium ion derivatives", "azanium ion derivative", "azanium ion derivatives" ; oboInOwl:id "CHEBI:35274" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ammonium ion derivative" ; rdfs:subClassOf obo:CHEBI_33702, obo:CHEBI_51143, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_28938 ] . obo:CHEBI_35281 obo:IAO_0000115 "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." ; oboInOwl:hasExactSynonym "betaines" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "onium betaines" ; oboInOwl:id "CHEBI:35281" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "onium betaine" ; rdfs:subClassOf obo:CHEBI_27369 . obo:CHEBI_35284 obo:IAO_0000115 "Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ammonium betaines" ; oboInOwl:id "CHEBI:35284" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ammonium betaine" ; rdfs:subClassOf obo:CHEBI_26469, obo:CHEBI_35281 . obo:CHEBI_35313 oboInOwl:hasExactSynonym "hexoside" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hexosides" ; oboInOwl:id "CHEBI:35313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexoside" ; rdfs:subClassOf obo:CHEBI_24400 . obo:CHEBI_35341 obo:IAO_0000115 "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." ; chebi:charge "0" ; chebi:formula "C19H31R" ; chebi:mass "259.450" ; chebi:monoisotopicmass "259.24258" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C" ; oboInOwl:hasAlternativeId "CHEBI:13687", "CHEBI:26768", "CHEBI:9263" ; oboInOwl:hasDbXref "KEGG:C00377", "MetaCyc:Steroids" ; oboInOwl:hasExactSynonym "Steroid", "steroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a steroid" ; oboInOwl:id "CHEBI:35341" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_51958 . obo:CHEBI_35342 obo:IAO_0000115 "The alpha-stereoisomer of 17-hydroxy steroid." ; oboInOwl:hasAlternativeId "CHEBI:13585", "CHEBI:19174", "CHEBI:782" ; oboInOwl:hasDbXref "KEGG:C03336" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17-alpha-Hydroxysteroid", "17alpha-hydroxy steroids" ; oboInOwl:id "CHEBI:35342" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "17alpha-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_36838 . obo:CHEBI_35343 obo:IAO_0000115 "A 17-hydroxy steroid in which the hydroxy group at position 17 has a beta-configuration." ; chebi:charge "0" ; chebi:formula "C18H29OR" ; chebi:mass "261.423" ; chebi:monoisotopicmass "261.22184" ; chebi:smiles "CC12CCC3C(CCC4CCCCC34[*])C1CC[C@@H]2O" ; oboInOwl:hasAlternativeId "CHEBI:19176", "CHEBI:794" ; oboInOwl:hasDbXref "KEGG:C03051", "MetaCyc:17-beta-Hydroxysteroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17beta-hydroxy steroids", "17beta-hydroxysteroid", "17beta-hydroxysteroids", "a 17beta-hydroxy steroid" ; oboInOwl:id "CHEBI:35343" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "17beta-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_36838 . obo:CHEBI_35344 oboInOwl:hasAlternativeId "CHEBI:1300", "CHEBI:13596", "CHEBI:19803" ; oboInOwl:hasDbXref "KEGG:C02506" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "21-Hydroxysteroid", "21-hydroxy steroids", "21-hydroxysteroids" ; oboInOwl:id "CHEBI:35344" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "21-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_35350 . obo:CHEBI_35346 obo:IAO_0000115 "Any 11-hydroxy steroid in which the hydroxy group at position 11 has beta- configuration." ; chebi:charge "0" ; chebi:formula "C19H31OR" ; chebi:mass "275.450" ; chebi:monoisotopicmass "275.23749" ; chebi:smiles "C12(CCCCC1CCC3C2[C@H](CC4(C3CCC4*)C)O)C" ; oboInOwl:hasAlternativeId "CHEBI:13774", "CHEBI:19134", "CHEBI:738" ; oboInOwl:hasDbXref "KEGG:C01058" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "11beta-Hydroxysteroid", "11beta-hydroxy steroids", "11beta-hydroxysteroids", "an 11beta-hydroxysteroid" ; oboInOwl:id "CHEBI:35346" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "11beta-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_36841 . obo:CHEBI_35348 obo:IAO_0000115 "A sterol in which the hydroxy group at position 3 has beta- configuration." ; chebi:charge "0" ; chebi:formula "C19H31OR" ; chebi:mass "275.450" ; chebi:monoisotopicmass "275.23749" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CC[C@@H](C4)O)C" ; oboInOwl:hasAlternativeId "CHEBI:13609", "CHEBI:1725", "CHEBI:1726", "CHEBI:20248" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3beta-hydroxysteroids", "3beta-sterols" ; oboInOwl:id "CHEBI:35348" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3beta-sterol" ; rdfs:subClassOf obo:CHEBI_15889, obo:CHEBI_36836 . obo:CHEBI_35350 oboInOwl:hasAlternativeId "CHEBI:24748", "CHEBI:5814" ; oboInOwl:hasDbXref "KEGG:C02159" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hydroxysteroid", "hydroxy steroids", "hydroxysteroids" ; oboInOwl:id "CHEBI:35350" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_33822, obo:CHEBI_35341 . obo:CHEBI_35352 obo:IAO_0000115 "Any heteroorganic entity containing at least one carbon-nitrogen bond." ; oboInOwl:hasExactSynonym "organonitrogen compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organonitrogens" ; oboInOwl:id "CHEBI:35352" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organonitrogen compound" ; rdfs:subClassOf obo:CHEBI_33285, obo:CHEBI_51143 . obo:CHEBI_35366 obo:IAO_0000115 "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." ; chebi:charge "0" ; chebi:formula "CHO2R" ; chebi:mass "45.01740" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "OC([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13633", "CHEBI:24024", "CHEBI:4984" ; oboInOwl:hasDbXref "KEGG:C00162", "PMID:14287444", "PMID:14300208", "PMID:14328676", "Wikipedia:Fatty_acid" ; oboInOwl:hasExactSynonym "Fatty acid", "fatty acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Fettsaeure", "Fettsaeuren", "acide gras", "acides gras", "acido graso", "acidos grasos", "fatty acids" ; oboInOwl:id "CHEBI:35366" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_25384, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28868 ] . obo:CHEBI_35381 obo:IAO_0000115 "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." ; oboInOwl:hasAlternativeId "CHEBI:25407", "CHEBI:6984" ; oboInOwl:hasDbXref "KEGG:C06698" ; oboInOwl:hasExactSynonym "Monosaccharide", "monosaccharides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Monosaccharid", "Monosacharid", "monosacarido", "monosacaridos" ; oboInOwl:id "CHEBI:35381" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monosaccharide" ; rdfs:subClassOf obo:CHEBI_16646 . obo:CHEBI_35391 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of aspartic acid." ; chebi:charge "-1" ; chebi:formula "C4H6NO4" ; chebi:inchi "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1" ; chebi:inchikey "CKLJMWTZIZZHCS-UHFFFAOYSA-M" ; chebi:mass "132.09478" ; chebi:monoisotopicmass "132.03023" ; chebi:smiles "[NH3+]C(CC([O-])=O)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:22659", "CHEBI:29992" ; oboInOwl:hasExactSynonym "aspartate(1-)", "hydrogen aspartate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammoniobutanedioate", "2-ammoniosuccinate", "aspartic acid monoanion" ; oboInOwl:id "CHEBI:35391" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aspartate(1-)" ; rdfs:subClassOf obo:CHEBI_132943, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_29995 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22660 ] . obo:CHEBI_35406 obo:IAO_0000115 "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." ; oboInOwl:hasAlternativeId "CHEBI:33274", "CHEBI:33436" ; oboInOwl:hasExactSynonym "oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxoacid anions", "oxoanions" ; oboInOwl:id "CHEBI:35406" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxoanion" ; rdfs:subClassOf obo:CHEBI_25741, obo:CHEBI_33273 . obo:CHEBI_35418 obo:IAO_0000115 "A ketoaldonate that is the conjugate base of N-acetylneuraminic acid, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C11H18NO9" ; chebi:inchi "InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1" ; chebi:inchikey "SQVRNKJHWKZAKO-LUWBGTNYSA-M" ; chebi:mass "308.26196" ; chebi:monoisotopicmass "308.09870" ; chebi:smiles "[H][C@]1(OC(O)(C[C@H](O)[C@H]1NC(C)=O)C([O-])=O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasAlternativeId "CHEBI:12471", "CHEBI:12579", "CHEBI:21617", "CHEBI:33987" ; oboInOwl:hasDbXref "MetaCyc:N-ACETYLNEURAMINATE", "Reaxys:9227329" ; oboInOwl:hasExactSynonym "5-acetamido-3,5-dideoxy-D-galacto-non-2-ulopyranosonate", "N-acetylneuraminate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sialate" ; oboInOwl:id "CHEBI:35418" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetylneuraminate" ; rdfs:subClassOf obo:CHEBI_21619, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17012 ] . obo:CHEBI_35441 obo:IAO_0000115 "A substance used in the prophylaxis or therapy of infectious diseases." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-infective agents", "anti-infective drugs", "antiinfective agents", "antiinfective drug" ; oboInOwl:id "CHEBI:35441" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antiinfective agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35469 obo:IAO_0000115 "Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antidepressant drugs", "antidepressants", "thymoanaleptics", "thymoleptic drugs", "thymoleptics" ; oboInOwl:id "CHEBI:35469" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antidepressant" ; rdfs:subClassOf obo:CHEBI_35471 . obo:CHEBI_35470 obo:IAO_0000115 "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CNS agent", "CNS drugs", "central nervous system agents" ; oboInOwl:id "CHEBI:35470" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "central nervous system drug" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35471 obo:IAO_0000115 "A loosely defined grouping of drugs that have effects on psychological function." ; oboInOwl:hasDbXref "Wikipedia:Psychotropic_drug" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "psychoactive agent", "psychoactive drugs", "psychopharmaceuticals", "psychotropic drugs" ; oboInOwl:id "CHEBI:35471" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "psychotropic drug" ; rdfs:subClassOf obo:CHEBI_35470 . obo:CHEBI_35472 obo:IAO_0000115 "A substance that reduces or suppresses inflammation." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-inflammatory drugs", "antiinflammatory agent", "antiinflammatory drug", "antiinflammatory drugs" ; oboInOwl:id "CHEBI:35472" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anti-inflammatory drug" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_67079 . obo:CHEBI_35479 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkali metal salts" ; oboInOwl:id "CHEBI:35479" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkali metal salt" ; rdfs:subClassOf obo:CHEBI_24866, obo:CHEBI_33296 . obo:CHEBI_35488 obo:IAO_0000115 "A loosely defined group of drugs that tend to reduce the activity of the central nervous system." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CNS depressants", "central nervous system depressants" ; oboInOwl:id "CHEBI:35488" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "central nervous system depressant" ; rdfs:subClassOf obo:CHEBI_35470 . obo:CHEBI_35489 obo:IAO_0000115 "Compounds of structure RSSR in which R and R' are organic groups." ; chebi:charge "0" ; chebi:formula "S2R2" ; chebi:mass "64.13000" ; chebi:monoisotopicmass "63.94414" ; chebi:smiles "[*]SS[*]" ; oboInOwl:hasExactSynonym "disulfides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an organic disulfide", "organic disulfides" ; oboInOwl:id "CHEBI:35489" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic disulfide" ; rdfs:subClassOf obo:CHEBI_33261, obo:CHEBI_48343 . obo:CHEBI_35492 obo:IAO_0000115 "An amino acid zwitterion that is the tautomer of cystine." ; chebi:charge "0" ; chebi:formula "C6H12N2O4S2" ; chebi:inchi "InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)" ; chebi:inchikey "LEVWYRKDKASIDU-UHFFFAOYSA-N" ; chebi:mass "240.30256" ; chebi:monoisotopicmass "240.02385" ; chebi:smiles "[NH3+]C(CSSCC([NH3+])C([O-])=O)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:51007" ; oboInOwl:hasExactSynonym "3,3'-disulfanediylbis(2-ammoniopropanoate)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,3'-dithiobis(2-ammoniopropanoate)" ; oboInOwl:id "CHEBI:35492" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cystine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17376 ] . obo:CHEBI_35507 oboInOwl:hasExactSynonym "natural product fundamental parents" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35507" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "natural product fundamental parent" ; rdfs:subClassOf obo:CHEBI_33245 . obo:CHEBI_35508 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "steroid fundamental parents" ; oboInOwl:id "CHEBI:35508" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid fundamental parent" ; rdfs:subClassOf obo:CHEBI_35341, obo:CHEBI_35507 . obo:CHEBI_35509 chebi:charge "0" ; chebi:formula "C19H32" ; chebi:inchi "InChI=1S/C19H32/c1-18-11-5-7-16(18)15-9-8-14-6-3-4-12-19(14,2)17(15)10-13-18/h14-17H,3-13H2,1-2H3/t14?,15-,16-,17-,18-,19-/m0/s1" ; chebi:inchikey "QZLYKIGBANMMBK-FZFXZXLVSA-N" ; chebi:mass "260.45738" ; chebi:monoisotopicmass "260.25040" ; chebi:smiles "[H][C@@]12CCC3CCCC[C@]3(C)[C@@]1([H])CC[C@]1(C)CCC[C@@]21[H]" ; oboInOwl:hasDbXref "Beilstein:5247532", "CAS:24887-75-0", "LIPID_MAPS_instance:LMST02020000" ; oboInOwl:hasExactSynonym "androstane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35509" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "androstane" ; rdfs:subClassOf obo:CHEBI_35508 . obo:CHEBI_35516 chebi:charge "0" ; chebi:formula "C27H48" ; chebi:inchi "InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21?,22+,23-,24+,25+,26+,27-/m1/s1" ; chebi:inchikey "XIIAYQZJNBULGD-LDHZKLTISA-N" ; chebi:mass "372.67002" ; chebi:monoisotopicmass "372.37560" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C" ; oboInOwl:hasDbXref "Beilstein:5334741", "CAS:14982-53-7", "LIPID_MAPS_instance:LMST01010000", "Wikipedia:Cholestane" ; oboInOwl:hasExactSynonym "cholestane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35516" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholestane" ; rdfs:subClassOf obo:CHEBI_35508 . obo:CHEBI_35519 chebi:charge "0" ; chebi:formula "C24H42" ; chebi:inchi "InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18?,19+,20-,21+,22+,23+,24-/m1/s1" ; chebi:inchikey "QSHQKIURKJITMZ-BRPMRXRMSA-N" ; chebi:mass "330.59028" ; chebi:monoisotopicmass "330.32865" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC" ; oboInOwl:hasExactSynonym "cholane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35519" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholane" ; rdfs:subClassOf obo:CHEBI_35508 . obo:CHEBI_35522 obo:IAO_0000115 "An agent that selectively binds to and activates beta-adrenergic receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-adrenergic agonists", "beta-adrenergic receptor agonist", "beta-adrenoceptor agonists" ; oboInOwl:id "CHEBI:35522" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-adrenergic agonist" ; rdfs:subClassOf obo:CHEBI_37886, obo:CHEBI_48540 . obo:CHEBI_35523 obo:IAO_0000115 "An agent that causes an increase in the expansion of a bronchus or bronchial tubes." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "bronchodilator", "bronchodilator agents", "broncholytic agent" ; oboInOwl:id "CHEBI:35523" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bronchodilator agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35524 obo:IAO_0000115 "A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sympathomimetic", "sympathomimetics" ; oboInOwl:id "CHEBI:35524" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sympathomimetic agent" ; rdfs:subClassOf obo:CHEBI_37962 . obo:CHEBI_35526 obo:IAO_0000115 "A drug which lowers the blood glucose level." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antidiabetic", "antihyperglycemic", "antihyperglycemic agent", "antihyperglycemic agents", "antihyperglycemic drug", "antihyperglycemic drugs", "antihyperglycemics", "hypoglycemic agents", "hypoglycemic drug", "hypoglycemic drugs" ; oboInOwl:id "CHEBI:35526" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hypoglycemic agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35552 oboInOwl:hasExactSynonym "heterocyclic parent hydrides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heterocyclic fundamental parent", "heterocyclic organic fundamental parents", "organic heterocyclic fundamental parents" ; oboInOwl:id "CHEBI:35552" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heterocyclic organic fundamental parent" ; rdfs:subClassOf obo:CHEBI_33245 . obo:CHEBI_35554 obo:IAO_0000115 "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cardiovascular agent", "cardiovascular drugs" ; oboInOwl:id "CHEBI:35554" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cardiovascular drug" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35568 obo:IAO_0000115 "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." ; oboInOwl:hasExactSynonym "mancude-ring systems" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mancude rings", "mancunide-ring systems" ; oboInOwl:id "CHEBI:35568" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mancude ring" ; rdfs:subClassOf obo:CHEBI_23367 . obo:CHEBI_35569 obo:IAO_0000115 "An agent that selectively binds to and activates alpha-adrenergic receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-adrenergic agonists", "alpha-adrenergic receptor agonist", "alpha-adrenoceptor agonists" ; oboInOwl:id "CHEBI:35569" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-adrenergic agonist" ; rdfs:subClassOf obo:CHEBI_37886, obo:CHEBI_48539 . obo:CHEBI_35570 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mancude organic heterobicyclic parents", "mancude-ring organic heterobicyclic parents" ; oboInOwl:id "CHEBI:35570" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mancude organic heterobicyclic parent" ; rdfs:subClassOf obo:CHEBI_27171, obo:CHEBI_35571 . obo:CHEBI_35571 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mancude organic heterocyclic parents", "mancude-ring organic heterocyclic parents" ; oboInOwl:id "CHEBI:35571" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mancude organic heterocyclic parent" ; rdfs:subClassOf obo:CHEBI_35552, obo:CHEBI_35573 . obo:CHEBI_35573 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic mancude parents", "organic mancude-ring parents" ; oboInOwl:id "CHEBI:35573" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic mancude parent" ; rdfs:subClassOf obo:CHEBI_33245, obo:CHEBI_35568 . obo:CHEBI_35584 obo:IAO_0000115 "A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines." ; chebi:charge "0" ; chebi:formula "C5H4N4" ; chebi:mass "120.112" ; chebi:monoisotopicmass "120.04360" ; oboInOwl:hasDbXref "HMDB:HMDB0001366", "KEGG:C15587", "MetaCyc:PURINE", "PMID:12865945", "PMID:24088627" ; oboInOwl:hasExactSynonym "purine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35584" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "purine" ; rdfs:subClassOf obo:CHEBI_26401, obo:CHEBI_35570, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ] . obo:CHEBI_35586 obo:IAO_0000115 "The 1H-tautomer of purine." ; chebi:charge "0" ; chebi:formula "C5H4N4" ; chebi:inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" ; chebi:inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" ; chebi:mass "120.11210" ; chebi:monoisotopicmass "120.04360" ; chebi:smiles "c1nc2c[nH]cnc2n1" ; oboInOwl:hasDbXref "Gmelin:2379911" ; oboInOwl:hasExactSynonym "1H-purine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35586" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1H-purine" ; rdfs:subClassOf obo:CHEBI_35584, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17258 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35588 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35589 ] . obo:CHEBI_35588 obo:IAO_0000115 "The 3H-tautomer of purine." ; chebi:charge "0" ; chebi:formula "C5H4N4" ; chebi:inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" ; chebi:inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" ; chebi:mass "120.11222" ; chebi:monoisotopicmass "120.04360" ; chebi:smiles "c1nc2cnc[nH]c2n1" ; oboInOwl:hasDbXref "PMID:6149478", "PMID:7178185", "PMID:7296170", "Reaxys:1210196" ; oboInOwl:hasExactSynonym "3H-purine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35588" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3H-purine" ; rdfs:subClassOf obo:CHEBI_35584, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17258 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35586 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35589 ] . obo:CHEBI_35589 obo:IAO_0000115 "The 9H-tautomer of purine." ; chebi:charge "0" ; chebi:formula "C5H4N4" ; chebi:inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" ; chebi:inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" ; chebi:mass "120.11222" ; chebi:monoisotopicmass "120.04360" ; chebi:smiles "c1ncc2nc[nH]c2n1" ; oboInOwl:hasDbXref "Beilstein:606899", "CAS:120-73-0", "Gmelin:3120", "Wikipedia:Purine" ; oboInOwl:hasExactSynonym "9H-purine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35589" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "9H-purine" ; rdfs:subClassOf obo:CHEBI_35584, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17258 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35586 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_35588 ] . obo:CHEBI_35604 obo:IAO_0000115 "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." ; oboInOwl:hasExactSynonym "carbon oxoanion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbon oxoanions", "oxocarbon anion", "oxocarbon anions" ; oboInOwl:id "CHEBI:35604" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon oxoanion" ; rdfs:subClassOf obo:CHEBI_25696, obo:CHEBI_35406, obo:CHEBI_36963 . obo:CHEBI_35605 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbon oxoacids", "oxoacids of carbon" ; oboInOwl:id "CHEBI:35605" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbon oxoacid" ; rdfs:subClassOf obo:CHEBI_24833, obo:CHEBI_36963 . obo:CHEBI_35610 obo:IAO_0000115 "A substance that inhibits or prevents the proliferation of neoplasms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anticancer agent", "anticancer agents", "antineoplastic", "antineoplastic agents", "cytostatic" ; oboInOwl:id "CHEBI:35610" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antineoplastic agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35617 obo:IAO_0000115 "A food additive that is used to added improve the taste or odour of a food." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "flavoring agent", "flavoring agents", "flavour enhancer", "flavour enhancers", "flavouring agents" ; oboInOwl:id "CHEBI:35617" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "flavouring agent" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_35618 obo:IAO_0000115 "Any ether in which the oxygen is attached to at least one aryl substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35618" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic ether" ; rdfs:subClassOf obo:CHEBI_25698, obo:CHEBI_33659 . obo:CHEBI_35620 obo:IAO_0000115 "A drug used to cause dilation of the blood vessels." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vasodilator", "vasodilator agents" ; oboInOwl:id "CHEBI:35620" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vasodilator agent" ; rdfs:subClassOf obo:CHEBI_35554 . obo:CHEBI_35621 obo:IAO_0000115 "An alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2." ; chebi:charge "0" ; chebi:formula "C4H9NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)" ; chebi:inchikey "QWCKQJZIFLGMSD-UHFFFAOYSA-N" ; chebi:mass "103.11980" ; chebi:monoisotopicmass "103.06333" ; chebi:smiles "CCC(N)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:635889", "CAS:2835-81-6", "DrugBank:DB04454", "Gmelin:217679", "MetaCyc:CPD-3686", "PMID:11958629", "PMID:15246869", "PMID:20551690", "PMID:22061039", "PMID:22264337", "PMID:22770225", "Reaxys:635889", "Wikipedia:Alpha-Aminobutyric_acid" ; oboInOwl:hasExactSynonym "2-aminobutanoic acid", "alpha-aminobutyric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-amino-n-butyric acid", "2-aminobutyric acid", "AABA", "Abu", "alpha-amino-n-butyric acid", "butyrine", "homoalanine" ; oboInOwl:id "CHEBI:35621" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-aminobutyric acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_86508 ] . obo:CHEBI_35623 obo:IAO_0000115 "A drug used to prevent seizures or reduce their severity." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Antiepileptika", "Antiepileptikum", "Antikonvulsiva", "Antikonvulsivum", "anti-convulsant", "anti-convulsants", "anti-convulsive agent", "anti-convulsive agents", "anticonvulsants", "anticonvulsive agent", "anticonvulsive agents", "antiepileptic", "antiepileptics", "antiepileptique", "antiepileptiques" ; oboInOwl:id "CHEBI:35623" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anticonvulsant" ; rdfs:subClassOf obo:CHEBI_35488 . obo:CHEBI_356416 obo:IAO_0000115 "The zwitterion formed from 5-aminolevulinic acid by transfer of a proton from the carboxy group to the amino group. It is the major species present at physiological pH." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)" ; chebi:inchikey "ZGXJTSGNIOSYLO-UHFFFAOYSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "[NH3+]CC(=O)CCC([O-])=O" ; oboInOwl:hasDbXref "PMID:14667225" ; oboInOwl:hasExactSynonym "5-azaniumyl-4-oxopentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-aminolevulinate", "5-ammonio-4-oxopentanoate", "5-ammonio-4-oxovalerate" ; oboInOwl:id "CHEBI:356416" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-ammoniolevulinate" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17549 ] . obo:CHEBI_35664 obo:IAO_0000115 "Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme." ; oboInOwl:hasDbXref "PMID:1464741", "PMID:15531285", "PMID:20467214", "Wikipedia:HMG-CoA_reductase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HMG-CoA reductase inhibitor", "HMG-CoA reductase inhibitors", "hydroxymethylglutaryl-CoA reductase inhibitor", "hydroxymethylglutaryl-CoA reductase inhibitors" ; oboInOwl:id "CHEBI:35664" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76835 . obo:CHEBI_35679 obo:IAO_0000115 "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." ; oboInOwl:hasDbXref "Wikipedia:Hypolipidemic_agent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antihyperlipemic", "antihyperlipemics", "antihyperlipidaemic agent", "antihyperlipidaemic agents", "antihyperlipidaemic drug", "antihyperlipidaemic drugs", "antihyperlipidemic", "antihyperlipidemic agent", "antihyperlipidemic agents", "antihyperlipidemic drug", "antihyperlipidemic drugs", "antihyperlipidemics", "antilipemic", "antilipemic drugs", "antilipemics", "hypolipidemic agent", "hypolipidemic agents", "lipid-lowering agent", "lipid-lowering agents", "lipid-lowering drug", "lipid-lowering drugs" ; oboInOwl:id "CHEBI:35679" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antilipemic drug" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_35681 obo:IAO_0000115 "A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." ; chebi:charge "0" ; chebi:formula "CH2OR2" ; chebi:mass "30.026" ; chebi:monoisotopicmass "30.01056" ; chebi:smiles "*C(*)O" ; oboInOwl:hasAlternativeId "CHEBI:13425", "CHEBI:13686", "CHEBI:26617", "CHEBI:58662", "CHEBI:8741", "CHEBI:9077" ; oboInOwl:hasDbXref "KEGG:C00432", "KEGG:C01612" ; oboInOwl:hasExactSynonym "Secondary alcohol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "R-CHOH-R'", "a secondary alcohol", "secondary alcohols" ; oboInOwl:id "CHEBI:35681" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "secondary alcohol" ; rdfs:subClassOf obo:CHEBI_30879 . obo:CHEBI_35692 obo:IAO_0000115 "Any carboxylic acid containing two carboxy groups." ; oboInOwl:hasAlternativeId "CHEBI:23692", "CHEBI:36172", "CHEBI:4501" ; oboInOwl:hasDbXref "KEGG:C02028" ; oboInOwl:hasExactSynonym "Dicarboxylic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acids" ; oboInOwl:id "CHEBI:35692" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_131927, obo:CHEBI_33575, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35693 ] . obo:CHEBI_35693 oboInOwl:hasExactSynonym "dicarboxylic acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acid anions" ; oboInOwl:id "CHEBI:35693" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35692 ] . obo:CHEBI_35695 obo:IAO_0000115 "Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acid monoanions" ; oboInOwl:id "CHEBI:35695" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid monoanion" ; rdfs:subClassOf obo:CHEBI_35693 . obo:CHEBI_35701 obo:IAO_0000115 "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." ; oboInOwl:hasAlternativeId "CHEBI:23960", "CHEBI:4859" ; oboInOwl:hasDbXref "KEGG:C00287", "Wikipedia:Ester" ; oboInOwl:hasExactSynonym "Ester" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "esters" ; oboInOwl:id "CHEBI:35701" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ester" ; rdfs:subClassOf obo:CHEBI_36963 . obo:CHEBI_35703 obo:IAO_0000115 "A xenobiotic (Greek, xenos \"foreign\"; bios \"life\") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means." ; oboInOwl:hasAlternativeId "CHEBI:10074", "CHEBI:27333" ; oboInOwl:hasDbXref "KEGG:C06708", "Wikipedia:Xenobiotic" ; oboInOwl:hasExactSynonym "Xenobiotic", "xenobiotic", "xenobiotics" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "xenobiotic compounds" ; oboInOwl:id "CHEBI:35703" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "xenobiotic" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_35718 obo:IAO_0000115 "An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antifungal", "antifungal agents", "antifungal drug", "antifungal drugs", "antifungals" ; oboInOwl:id "CHEBI:35718" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antifungal agent" ; rdfs:subClassOf obo:CHEBI_33281 . obo:CHEBI_35721 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35721" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "heparan sulfates" ; rdfs:subClassOf obo:CHEBI_24500, obo:CHEBI_35722 . obo:CHEBI_35722 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycosaminoglycan sulfate", "glycosaminoglycan sulfates", "sulfated glycosaminoglycans" ; oboInOwl:id "CHEBI:35722" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfated glycosaminoglycan" ; rdfs:subClassOf obo:CHEBI_18085, obo:CHEBI_35724 . obo:CHEBI_35724 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate sulfates", "carbohydrate sulphates" ; oboInOwl:id "CHEBI:35724" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate sulfate" ; rdfs:subClassOf obo:CHEBI_25704, obo:CHEBI_26819, obo:CHEBI_63299 . obo:CHEBI_35735 oboInOwl:hasAlternativeId "CHEBI:13210", "CHEBI:23691", "CHEBI:6976" ; oboInOwl:hasDbXref "KEGG:C04131" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dicarboxylic acid monoamides" ; oboInOwl:id "CHEBI:35735" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid monoamide" ; rdfs:subClassOf obo:CHEBI_23690, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_77450 ] . obo:CHEBI_35740 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "liposaccharides" ; oboInOwl:id "CHEBI:35740" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "liposaccharide" ; rdfs:subClassOf obo:CHEBI_18059, obo:CHEBI_63299 . obo:CHEBI_35741 obo:IAO_0000115 "Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached." ; oboInOwl:hasDbXref "PMID:18606873" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycerolipids" ; oboInOwl:id "CHEBI:35741" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycerolipid" ; rdfs:subClassOf obo:CHEBI_18059, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17754 ] . obo:CHEBI_35744 obo:IAO_0000115 "Any fatty acid containing a ring composed of carbon atoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbocyclic fatty acids" ; oboInOwl:id "CHEBI:35744" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbocyclic fatty acid" ; rdfs:subClassOf obo:CHEBI_59238, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_157668 ] . obo:CHEBI_35753 obo:IAO_0000115 "Any anion of a tricarboxylic acid formed by deprotonation of at least one carboxy group." ; oboInOwl:hasExactSynonym "tricarboxylic acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tricarboxylic acid anions" ; oboInOwl:id "CHEBI:35753" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tricarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27093 ] . obo:CHEBI_35757 obo:IAO_0000115 "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.01000" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13657", "CHEBI:25382", "CHEBI:3407" ; oboInOwl:hasDbXref "KEGG:C00060" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Carboxylate", "Monocarboxylate", "a monocarboxylate", "monocarboxylates", "monocarboxylic acid anions" ; oboInOwl:id "CHEBI:35757" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25384 ] . obo:CHEBI_35780 obo:IAO_0000115 "A phosphorus oxoanion that is the conjugate base of phosphoric acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Pi", "phosphate", "phosphate ions" ; oboInOwl:id "CHEBI:35780" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphate ion" ; rdfs:subClassOf obo:CHEBI_33461, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26078 ] . obo:CHEBI_35782 oboInOwl:hasAlternativeId "CHEBI:14177", "CHEBI:35781" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "PPi", "diphosphate ions" ; oboInOwl:id "CHEBI:35782" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphate ion" ; rdfs:subClassOf obo:CHEBI_33461 . obo:CHEBI_35788 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "seco-steroids" ; oboInOwl:id "CHEBI:35788" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "seco-steroid" ; rdfs:subClassOf obo:CHEBI_35341 . obo:CHEBI_35789 oboInOwl:hasAlternativeId "CHEBI:24979", "CHEBI:25804" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "keto steroids", "ketosteroids", "oxo steroids", "oxosteroids" ; oboInOwl:id "CHEBI:35789" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo steroid" ; rdfs:subClassOf obo:CHEBI_17087, obo:CHEBI_35341 . obo:CHEBI_35804 obo:IAO_0000115 "A tricarboxylic acid monoanion that is the conjugate base of citric acid, obtained by deprotonation of one of the three carboxy groups." ; chebi:charge "-1" ; chebi:formula "C6H7O7" ; chebi:mass "191.11558" ; chebi:monoisotopicmass "191.01918" ; oboInOwl:hasExactSynonym "dihydrogen citrate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2cit", "H2cit(-)" ; oboInOwl:id "CHEBI:35804" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrate(1-)" ; rdfs:subClassOf obo:CHEBI_133748, obo:CHEBI_36299, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35808 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_30769 ] . obo:CHEBI_35808 obo:IAO_0000115 "A tricarboxylic acid dianion obtained by deprotonation of two of the three carboxy groups of citric acid." ; chebi:charge "-2" ; chebi:formula "C6H6O7" ; chebi:mass "190.10764" ; chebi:monoisotopicmass "190.01135" ; oboInOwl:hasExactSynonym "hydrogen citrate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hcit", "Hcit(2-)" ; oboInOwl:id "CHEBI:35808" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrate(2-)" ; rdfs:subClassOf obo:CHEBI_133748, obo:CHEBI_36300, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16947 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35804 ] . obo:CHEBI_35819 obo:IAO_0000115 "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." ; oboInOwl:hasAlternativeId "CHEBI:22919", "CHEBI:3166" ; oboInOwl:hasDbXref "KEGG:C05996", "PMID:18318842" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "BCFA", "BCFAs", "Branched chain fatty acid", "branched fatty acid", "branched fatty acids", "branched-chain fatty acids" ; oboInOwl:id "CHEBI:35819" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58955 ] . obo:CHEBI_35821 obo:IAO_0000115 "A substance used to lower plasma cholesterol levels." ; oboInOwl:hasAlternativeId "CHEBI:64906" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anticholesteremic", "anticholesteremic agent", "anticholesteremic drugs", "antihypercholesterolemic", "antihypercholesterolemic agent", "antihypercholesterolemic agents", "antihypercholesterolemic drug", "antihypercholesterolemic drugs", "antihypercholesterolemics", "cholesterol inhibitor", "cholesterol-lowering agent", "cholesterol-lowering agents", "cholesterol-lowering drug", "cholesterol-lowering drugs", "hypocholesteremic agent" ; oboInOwl:id "CHEBI:35821" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anticholesteremic drug" ; rdfs:subClassOf obo:CHEBI_35679 . obo:CHEBI_35825 obo:IAO_0000115 "A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups." ; chebi:charge "0" ; chebi:formula "C8H8O3" ; chebi:inchi "InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)" ; chebi:inchikey "IWYDHOAUDWTVEP-UHFFFAOYSA-N" ; chebi:mass "152.14732" ; chebi:monoisotopicmass "152.04734" ; chebi:smiles "OC(C(O)=O)c1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:25149", "CHEBI:32801" ; oboInOwl:hasDbXref "Beilstein:510011", "CAS:90-64-2", "Drug_Central:1629", "Gmelin:218213", "HMDB:HMDB0000703", "PMID:22770225", "PMID:24278065", "PMID:4813698", "Reaxys:510011", "Wikipedia:Mandelic_acid" ; oboInOwl:hasExactSynonym "hydroxy(phenyl)acetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(RS)-Mandelic acid", "2-Hydroxy-2-phenylacetic acid", "2-Hydroxy-2-phenylethanoic acid", "DL-Mandelic acid", "Mandelsaeure", "alpha-hydroxybenzeneacetic acid" ; oboInOwl:id "CHEBI:35825" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mandelic acid" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_49302, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33282 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15366 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_25147 ] . obo:CHEBI_35868 obo:IAO_0000115 "Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy acid", "hydroxy monocarboxylic acids" ; oboInOwl:id "CHEBI:35868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_24669, obo:CHEBI_25384, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_36059 ] . obo:CHEBI_35871 obo:IAO_0000115 "Any monocarboxylic acid having at least one additional oxo functional group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo monocarboxylic acids" ; oboInOwl:id "CHEBI:35871" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_25754, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35902 ] . obo:CHEBI_35875 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "imidazopyrimidines" ; oboInOwl:id "CHEBI:35875" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidazopyrimidine" ; rdfs:subClassOf obo:CHEBI_27171, obo:CHEBI_33833, obo:CHEBI_38101 . obo:CHEBI_35881 oboInOwl:hasExactSynonym "pnictogen hydride" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pnictogen hydrides" ; oboInOwl:id "CHEBI:35881" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pnictogen hydride" ; rdfs:subClassOf obo:CHEBI_33242, obo:CHEBI_33302 . obo:CHEBI_35902 oboInOwl:hasAlternativeId "CHEBI:35178", "CHEBI:35901" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo monocarboxylic acid anions" ; oboInOwl:id "CHEBI:35902" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_35903, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35871 ] . obo:CHEBI_35903 obo:IAO_0000115 "Any carboxylic acid anion containing at least one oxo group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo carboxylic acid anions" ; oboInOwl:id "CHEBI:35903" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo carboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25754 ] . obo:CHEBI_35907 obo:IAO_0000115 "A dicarboxylic acid monoanion that is the conjugate base of glutaric acid." ; chebi:charge "-1" ; chebi:formula "C5H7O4" ; chebi:inchi "InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)/p-1" ; chebi:inchikey "JFCQEDHGNNZCLN-UHFFFAOYSA-M" ; chebi:mass "131.10668" ; chebi:monoisotopicmass "131.03498" ; chebi:smiles "OC(=O)CCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:30922", "CHEBI:35906" ; oboInOwl:hasDbXref "Beilstein:3904478", "Gmelin:326031", "Reaxys:3904478" ; oboInOwl:hasExactSynonym "4-carboxybutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydrogen glutarate" ; oboInOwl:id "CHEBI:35907" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glutarate(1-)" ; rdfs:subClassOf obo:CHEBI_24329, obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30921 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17859 ] . obo:CHEBI_35910 obo:IAO_0000115 "Any monocarboxylic acid having a 2-oxo substituent." ; chebi:charge "0" ; chebi:formula "C2HO3R" ; chebi:mass "73.02750" ; chebi:monoisotopicmass "72.99257" ; chebi:smiles "OC(=O)C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:11634", "CHEBI:1238", "CHEBI:13195", "CHEBI:13594", "CHEBI:19736", "CHEBI:35909" ; oboInOwl:hasDbXref "KEGG:C00161" ; oboInOwl:hasExactSynonym "2-oxo carboxylic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Oxo acid", "2-Oxocarboxylate", "2-oxo acid", "2-oxo monocarboxylic acids" ; oboInOwl:id "CHEBI:35910" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-oxo monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35871, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_35179 ] . obo:CHEBI_35915 obo:IAO_0000115 "A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol." ; chebi:charge "0" ; chebi:formula "C20H30O2R2" ; chebi:mass "302.452" ; chebi:monoisotopicmass "302.22458" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)OC(*)=O)C" ; oboInOwl:hasAlternativeId "CHEBI:13220", "CHEBI:15115", "CHEBI:26770", "CHEBI:26772", "CHEBI:9268", "CHEBI:9269" ; oboInOwl:hasDbXref "KEGG:C01958" ; oboInOwl:hasExactSynonym "Sterol ester" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxysteroid ester", "3-hydroxysteroid esters", "Steryl ester", "a sterol ester" ; oboInOwl:id "CHEBI:35915" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sterol ester" ; rdfs:subClassOf obo:CHEBI_33308, obo:CHEBI_47880 . obo:CHEBI_35931 obo:IAO_0000115 "A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position delta to the carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "delta-amino acids" ; oboInOwl:id "CHEBI:35931" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "delta-amino acid" ; rdfs:subClassOf obo:CHEBI_83820 . obo:CHEBI_35942 obo:IAO_0000115 "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "neurotransmitter agents" ; oboInOwl:id "CHEBI:35942" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neurotransmitter agent" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_52210 . obo:CHEBI_35950 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-oxo acid", "4-oxo monocarboxylic acids" ; oboInOwl:id "CHEBI:35950" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-oxo monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35871 . obo:CHEBI_35969 obo:IAO_0000115 "A hydroxy monocarboxylic acid that has a hydroxy group beta to the carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy acid", "3-hydroxy monocarboxylic acids", "beta-hydroxy acid", "beta-hydroxy acids", "beta-hydroxy carboxylic acid", "beta-hydroxy carboxylic acids" ; oboInOwl:id "CHEBI:35969" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35868, obo:CHEBI_61355 . obo:CHEBI_35972 obo:IAO_0000115 "Any hydroxy monocarboxylic acid carrying at least two hydroxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dihydroxy monocarboxylic acids" ; oboInOwl:id "CHEBI:35972" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dihydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35868 . obo:CHEBI_35987 obo:IAO_0000115 "Any amino acid carrying two amino groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:35987" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diamino acid" ; rdfs:subClassOf obo:CHEBI_33709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59561 ] . obo:CHEBI_36043 obo:IAO_0000115 "A drug used to treat or prevent microbial infections." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antimicrobial drugs" ; oboInOwl:id "CHEBI:36043" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antimicrobial drug" ; rdfs:subClassOf obo:CHEBI_33281, obo:CHEBI_35441 . obo:CHEBI_36044 obo:IAO_0000115 "A substance used in the prophylaxis or therapy of virus diseases." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-viral drug", "anti-virus drug", "antiviral drugs" ; oboInOwl:id "CHEBI:36044" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antiviral drug" ; rdfs:subClassOf obo:CHEBI_22587, obo:CHEBI_36043 . obo:CHEBI_36059 obo:IAO_0000115 "Any monocarboxylic acid anion carrying at least one hydroxy substituent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy monocarboxylic acid anions", "hydroxymonocarboxylic acid anion", "hydroxymonocarboxylic acid anions" ; oboInOwl:id "CHEBI:36059" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35868 ] . obo:CHEBI_36063 obo:IAO_0000115 "A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients)." ; oboInOwl:hasExactSynonym "oxytocic" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxytocic agents", "oxytocic drugs", "uterine stimulants" ; oboInOwl:id "CHEBI:36063" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxytocic" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_36078 oboInOwl:hasAlternativeId "CHEBI:22867", "CHEBI:50419" ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMST04" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "bile acids and derivatives", "cholanoids" ; oboInOwl:id "CHEBI:36078" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholanoid" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35519 ] . obo:CHEBI_36080 obo:IAO_0000115 "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." ; oboInOwl:hasAlternativeId "CHEBI:13677", "CHEBI:14911" ; oboInOwl:hasExactSynonym "proteins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36080" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "protein" ; rdfs:subClassOf obo:CHEBI_33695, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16541 ] . obo:CHEBI_36141 obo:IAO_0000115 "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." ; oboInOwl:hasAlternativeId "CHEBI:13684", "CHEBI:26517" ; oboInOwl:hasDbXref "Wikipedia:Quinone" ; oboInOwl:hasExactSynonym "quinone", "quinones" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chinon", "quinones" ; oboInOwl:id "CHEBI:36141" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "quinone" ; rdfs:subClassOf obo:CHEBI_3992 . obo:CHEBI_36145 obo:IAO_0000115 "Any dicarboxylic acid carrying one or more oxo groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo dicarboxylic acids" ; oboInOwl:id "CHEBI:36145" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo dicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_25754, obo:CHEBI_35692, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_133294 ] . obo:CHEBI_36147 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo dicarboxylates", "oxo-dicarboxylic acid dianion", "oxo-dicarboxylic acid dianions" ; oboInOwl:id "CHEBI:36147" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo dicarboxylate" ; rdfs:subClassOf obo:CHEBI_28965 . obo:CHEBI_36149 obo:IAO_0000115 "A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 2-hydroxyglutaric acid." ; chebi:charge "-1" ; chebi:formula "C5H7O5" ; chebi:inchi "InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/p-1" ; chebi:inchikey "HWXBTNAVRSUOJR-UHFFFAOYSA-M" ; chebi:mass "147.10610" ; chebi:monoisotopicmass "147.02990" ; chebi:smiles "[H+].OC(CCC([O-])=O)C([O-])=O" ; oboInOwl:hasExactSynonym "hydrogen 2-hydroxypentanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36149" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxyglutarate(1-)" ; rdfs:subClassOf obo:CHEBI_132941, obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35907 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_11596 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17084 ] . obo:CHEBI_36164 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino dicarboxylic acids" ; oboInOwl:id "CHEBI:36164" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino dicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_33709, obo:CHEBI_35692 . obo:CHEBI_36233 obo:IAO_0000115 "A compound in which two monosaccharides are joined by a glycosidic bond." ; oboInOwl:hasAlternativeId "CHEBI:23844", "CHEBI:4654" ; oboInOwl:hasDbXref "KEGG:C01911" ; oboInOwl:hasExactSynonym "Disaccharide", "disaccharides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Disaccharid", "Disacharid", "disacarido", "disacaridos" ; oboInOwl:id "CHEBI:36233" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "disaccharide" ; rdfs:subClassOf obo:CHEBI_50699 . obo:CHEBI_36237 obo:IAO_0000115 "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." ; chebi:charge "0" ; chebi:formula "C24H40O2" ; chebi:inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17?,18+,19-,20+,21+,23+,24-/m1/s1" ; chebi:inchikey "RPKLZQLYODPWTM-KBMWBBLPSA-N" ; chebi:mass "360.57320" ; chebi:monoisotopicmass "360.30283" ; chebi:smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O" ; oboInOwl:hasDbXref "CAS:25312-65-6", "Patent:JP2008069152", "Reaxys:13246008" ; oboInOwl:hasExactSynonym "cholan-24-oic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36237" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholanic acid" ; rdfs:subClassOf obo:CHEBI_36278 . obo:CHEBI_36238 chebi:charge "0" ; chebi:formula "C24H40O2" ; chebi:inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1" ; chebi:inchikey "RPKLZQLYODPWTM-LVVAJZGHSA-N" ; chebi:mass "360.57320" ; chebi:monoisotopicmass "360.30283" ; chebi:smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC(O)=O" ; oboInOwl:hasDbXref "Beilstein:3214794", "CAS:546-18-9", "LIPID_MAPS_instance:LMST04010441" ; oboInOwl:hasExactSynonym "5beta-cholan-24-oic acid", "5beta-cholanic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(5beta)-cholan-24-oic acid", "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid", "5beta-cholanoic acid", "ursocholanic acid" ; oboInOwl:id "CHEBI:36238" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5beta-cholanic acid" ; rdfs:subClassOf obo:CHEBI_36237, obo:CHEBI_36248 . obo:CHEBI_36242 obo:IAO_0000115 "A 2-oxo monocarboxylic acid anion obtained by removal of a proton from the carboxylic acid group of 3-(4-hydroxyphenyl)pyruvic acid." ; chebi:charge "-1" ; chebi:formula "C9H7O4" ; chebi:inchi "InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1" ; chebi:inchikey "KKADPXVIOXHVKN-UHFFFAOYSA-M" ; chebi:mass "179.14950" ; chebi:monoisotopicmass "179.03498" ; chebi:smiles "Oc1ccc(CC(=O)C([O-])=O)cc1" ; oboInOwl:hasAlternativeId "CHEBI:11725", "CHEBI:11727", "CHEBI:12016", "CHEBI:20425", "CHEBI:594665" ; oboInOwl:hasDbXref "Beilstein:3950858", "KEGG:C01179", "PMID:11948155", "PMID:14593448", "Reaxys:3950858", "UM-BBD_compID:c0235" ; oboInOwl:hasExactSynonym "3-(4-Hydroxyphenyl)pyruvate", "3-(4-hydroxyphenyl)-2-oxopropanoate", "3-(4-hydroxyphenyl)pyruvate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-(p-hydroxyphenyl)pyruvate", "4-Hydroxyphenylpyruvate", "HPP", "p-hydroxyphenylpyruvate" ; oboInOwl:id "CHEBI:36242" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-(4-hydroxyphenyl)pyruvate" ; rdfs:subClassOf obo:CHEBI_35179, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15361 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15999 ] . obo:CHEBI_36248 obo:IAO_0000115 "Members of the class of cholanic acids based on a 5beta-cholane skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5beta-cholanic acids" ; rdfs:subClassOf obo:CHEBI_136889, obo:CHEBI_36278, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_20664 ] . obo:CHEBI_36277 obo:IAO_0000115 "A salt of a bile acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "bile acid salts" ; oboInOwl:id "CHEBI:36277" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bile acid salt" ; rdfs:subClassOf obo:CHEBI_24868, obo:CHEBI_36078 . obo:CHEBI_36278 oboInOwl:hasAlternativeId "CHEBI:23166", "CHEBI:23211" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36278" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "cholanic acids" ; rdfs:subClassOf obo:CHEBI_36078, obo:CHEBI_47891 . obo:CHEBI_36299 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tricarboxylic acid monoanions" ; oboInOwl:id "CHEBI:36299" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tricarboxylic acid monoanion" ; rdfs:subClassOf obo:CHEBI_35753 . obo:CHEBI_36300 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tricarboxylic acid dianions" ; oboInOwl:id "CHEBI:36300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tricarboxylic acid dianion" ; rdfs:subClassOf obo:CHEBI_35753 . obo:CHEBI_36309 oboInOwl:hasExactSynonym "macrocyclic tetrapyrroles" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic tetrapyrroles", "macrocyclic tetrapyrrole" ; oboInOwl:id "CHEBI:36309" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic tetrapyrrole" ; rdfs:subClassOf obo:CHEBI_26932, obo:CHEBI_47882 . obo:CHEBI_36338 obo:IAO_0000115 "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "leptons" ; oboInOwl:id "CHEBI:36338" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lepton" ; rdfs:subClassOf obo:CHEBI_33233, obo:CHEBI_36340 . obo:CHEBI_36339 obo:IAO_0000115 "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "baryons" ; oboInOwl:id "CHEBI:36339" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "baryon" ; rdfs:subClassOf obo:CHEBI_36340, obo:CHEBI_36344 . obo:CHEBI_36340 obo:IAO_0000115 "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." ; oboInOwl:hasExactSynonym "fermion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fermions" ; oboInOwl:id "CHEBI:36340" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fermion" ; rdfs:subClassOf obo:CHEBI_36342 . obo:CHEBI_36342 obo:IAO_0000115 "A particle smaller than an atom." ; oboInOwl:hasDbXref "Wikipedia:Subatomic_particle" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "subatomic particles" ; oboInOwl:id "CHEBI:36342" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "subatomic particle" . obo:CHEBI_36343 obo:IAO_0000115 "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "composite particles" ; oboInOwl:id "CHEBI:36343" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "composite particle" ; rdfs:subClassOf obo:CHEBI_36342 . obo:CHEBI_36344 obo:IAO_0000115 "Hadron is a subatomic particle which experiences the strong force." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hadrons" ; oboInOwl:id "CHEBI:36344" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hadron" ; rdfs:subClassOf obo:CHEBI_36343 . obo:CHEBI_36347 obo:IAO_0000115 "A nucleus or any of its constituents in any of their energy states." ; oboInOwl:hasExactSynonym "nuclear particle" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36347" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nuclear particle" ; rdfs:subClassOf obo:CHEBI_36342 . obo:CHEBI_36357 obo:IAO_0000115 "Any molecular entity consisting of more than one atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyatomic entities" ; oboInOwl:id "CHEBI:36357" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyatomic entity" ; rdfs:subClassOf obo:CHEBI_23367, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_24433 ] . obo:CHEBI_36358 obo:IAO_0000115 "An ion consisting of more than one atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyatomic ions" ; oboInOwl:id "CHEBI:36358" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyatomic ion" ; rdfs:subClassOf obo:CHEBI_24870, obo:CHEBI_36357 . obo:CHEBI_36359 oboInOwl:hasExactSynonym "phosphorus oxoacid derivative" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36359" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphorus oxoacid derivative" ; rdfs:subClassOf obo:CHEBI_33241, obo:CHEBI_36360, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_33457 ] . obo:CHEBI_36360 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36360" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "phosphorus oxoacids and derivatives" ; rdfs:subClassOf obo:CHEBI_26082 . obo:CHEBI_36508 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36508" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "glycotriaosylceramide" ; rdfs:subClassOf obo:CHEBI_36520 . obo:CHEBI_36520 oboInOwl:hasAlternativeId "CHEBI:24253", "CHEBI:25672" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36520" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "oligoglycosylceramide" ; rdfs:subClassOf obo:CHEBI_17761, obo:CHEBI_25513 . obo:CHEBI_36526 oboInOwl:hasAlternativeId "CHEBI:22208", "CHEBI:2428" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36526" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "acidic glycosphingolipid" ; rdfs:subClassOf obo:CHEBI_24402 . obo:CHEBI_36544 obo:IAO_0000115 "A ganglioside in which the number of residues in the oligosaccharide chain is two." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sialodiosylceramides" ; oboInOwl:id "CHEBI:36544" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sialodiosylceramide" ; rdfs:subClassOf obo:CHEBI_28892 . obo:CHEBI_36586 obo:IAO_0000115 "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." ; oboInOwl:hasExactSynonym "carbonyl compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36586" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbonyl compound" ; rdfs:subClassOf obo:CHEBI_36587, obo:CHEBI_36963, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_23019 ] . obo:CHEBI_36587 obo:IAO_0000115 "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." ; oboInOwl:hasExactSynonym "oxo compounds" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic oxo compounds" ; oboInOwl:id "CHEBI:36587" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic oxo compound" ; rdfs:subClassOf obo:CHEBI_72695, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_46629 ] . obo:CHEBI_36606 obo:IAO_0000115 "Compounds consisting of two acyl groups bonded to the same oxygen atom acyl-O-acyl." ; oboInOwl:hasExactSynonym "acid anhydride", "acid anhydrides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acid anhydrides", "anhydride d'acide" ; oboInOwl:id "CHEBI:36606" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acid anhydride" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_36608 oboInOwl:hasExactSynonym "acyclic acid anhydride", "acyclic acid anhydrides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acyclic acid anhydrides", "acyclic anhydrides" ; oboInOwl:id "CHEBI:36608" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acyclic acid anhydride" ; rdfs:subClassOf obo:CHEBI_36606 . obo:CHEBI_36699 obo:IAO_0000115 "Any of a class of steroid hormones that are produced in the adrenal cortex." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "adrenal cortex hormones", "corticosteroid hormones" ; oboInOwl:id "CHEBI:36699" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "corticosteroid hormone" ; rdfs:subClassOf obo:CHEBI_26764, obo:CHEBI_50858 . obo:CHEBI_36711 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "phosphoethanolamines" ; oboInOwl:id "CHEBI:36711" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphoethanolamine" ; rdfs:subClassOf obo:CHEBI_25703, obo:CHEBI_37734, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_23981 ] . obo:CHEBI_36735 obo:IAO_0000115 "Compounds based on a biladiene skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:36735" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biladienes" ; rdfs:subClassOf obo:CHEBI_25046 . obo:CHEBI_36818 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "seco-cholestanes" ; oboInOwl:id "CHEBI:36818" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "seco-cholestane" ; rdfs:subClassOf obo:CHEBI_35788 . obo:CHEBI_36830 chebi:charge "-1" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoanions" ; oboInOwl:id "CHEBI:36830" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoanion" ; rdfs:subClassOf obo:CHEBI_22563 . obo:CHEBI_36834 obo:IAO_0000115 "Any hydroxy steroid carrying a hydroxy group at position 3." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy steroids" ; oboInOwl:id "CHEBI:36834" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_35350 . obo:CHEBI_36836 obo:IAO_0000115 "A 3-hydroxy steroid in which the 3-hydroxy substituent is in the beta-position." ; chebi:charge "0" ; chebi:formula "C19H31OR" ; chebi:mass "275.450" ; chebi:monoisotopicmass "275.23749" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CC[C@@H](C4)O)C" ; oboInOwl:hasAlternativeId "CHEBI:71195" ; oboInOwl:hasDbXref "KEGG:C02945", "MetaCyc:3-Beta-Hydroxysterols", "PMID:10535978", "PMID:12829805" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3beta-hydroxy steroids", "a 3beta-hydroxysteroid" ; oboInOwl:id "CHEBI:36836" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3beta-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_35681, obo:CHEBI_36834 . obo:CHEBI_36838 obo:IAO_0000115 "A hydroxy steroid carrying a hydroxy group at position 17." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "17-hydroxy steroids" ; oboInOwl:id "CHEBI:36838" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "17-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_35350 . obo:CHEBI_36841 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "11-hydroxy steroids" ; oboInOwl:id "CHEBI:36841" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "11-hydroxy steroid" ; rdfs:subClassOf obo:CHEBI_35350 . obo:CHEBI_36853 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxy seco-steroids" ; oboInOwl:id "CHEBI:36853" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy seco-steroid" ; rdfs:subClassOf obo:CHEBI_35350, obo:CHEBI_35788 . obo:CHEBI_36885 obo:IAO_0000115 "An oxo steroid carrying an oxo group at position 20." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "20-oxo steroids" ; oboInOwl:id "CHEBI:36885" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "20-oxo steroid" ; rdfs:subClassOf obo:CHEBI_35789 . obo:CHEBI_36887 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "18-oxo steroids" ; oboInOwl:id "CHEBI:36887" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "18-oxo steroid" ; rdfs:subClassOf obo:CHEBI_35789 . obo:CHEBI_36902 oboInOwl:hasExactSynonym "chalcogen hydride" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chalcogen hydrides" ; oboInOwl:id "CHEBI:36902" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcogen hydride" ; rdfs:subClassOf obo:CHEBI_33242, obo:CHEBI_33304 . obo:CHEBI_36914 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic ions" ; oboInOwl:id "CHEBI:36914" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic ion" ; rdfs:subClassOf obo:CHEBI_24835, obo:CHEBI_24870 . obo:CHEBI_36915 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "inorganic cations" ; oboInOwl:id "CHEBI:36915" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inorganic cation" ; rdfs:subClassOf obo:CHEBI_36914, obo:CHEBI_36916 . obo:CHEBI_36916 obo:IAO_0000115 "A monoatomic or polyatomic species having one or more elementary charges of the proton." ; oboInOwl:hasAlternativeId "CHEBI:23058", "CHEBI:3473" ; oboInOwl:hasDbXref "KEGG:C01373" ; oboInOwl:hasExactSynonym "Cation", "cation" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Kation", "Kationen", "cationes", "cations" ; oboInOwl:id "CHEBI:36916" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cation" ; rdfs:subClassOf obo:CHEBI_24870 . obo:CHEBI_36961 oboInOwl:hasExactSynonym "chalcocarbonic acid", "chalcocarbonic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chalcocarbonic acids" ; oboInOwl:id "CHEBI:36961" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chalcocarbonic acid" ; rdfs:subClassOf obo:CHEBI_36962 . obo:CHEBI_36962 obo:IAO_0000115 "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." ; oboInOwl:hasExactSynonym "organochalcogen compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organochalcogen compounds" ; oboInOwl:id "CHEBI:36962" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organochalcogen compound" ; rdfs:subClassOf obo:CHEBI_33285, obo:CHEBI_33304 . obo:CHEBI_36963 obo:IAO_0000115 "An organochalcogen compound containing at least one carbon-oxygen bond." ; oboInOwl:hasDbXref "PMID:17586126" ; oboInOwl:hasExactSynonym "organooxygen compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organooxygen compounds" ; oboInOwl:id "CHEBI:36963" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organooxygen compound" ; rdfs:subClassOf obo:CHEBI_25806, obo:CHEBI_36962 . obo:CHEBI_37022 oboInOwl:hasExactSynonym "amino-acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino acid anions", "amino-acid anions" ; oboInOwl:id "CHEBI:37022" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino-acid anion" ; rdfs:subClassOf obo:CHEBI_29067, obo:CHEBI_35352, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33709 ] . obo:CHEBI_37024 obo:IAO_0000115 "An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine." ; chebi:charge "0" ; chebi:formula "C6H11NO4" ; chebi:inchi "InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)" ; chebi:inchikey "OYIFNHCXNCRBQI-UHFFFAOYSA-N" ; chebi:mass "161.15588" ; chebi:monoisotopicmass "161.06881" ; chebi:smiles "NC(CCCC(O)=O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:64698" ; oboInOwl:hasDbXref "Beilstein:1724349", "Beilstein:1773077", "CAS:542-32-5", "HMDB:HMDB0000510", "PMID:22264337", "PMID:31148", "PMID:6462455", "Reaxys:1724349", "Wikipedia:Alpha-Aminoadipic_acid" ; oboInOwl:hasExactSynonym "2-aminoadipic acid", "2-aminohexanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+/-)-2-Aminoadipic acid", "Aad", "DL-2-Aminoadipic acid", "DL-2-Aminohexanedioic acid", "DL-alpha-Aminoadipic acid", "alpha-Aminoadipic acid", "alpha-aminoadipic acid", "aminoadipic acid" ; oboInOwl:id "CHEBI:37024" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-aminoadipic acid" ; rdfs:subClassOf obo:CHEBI_189840, obo:CHEBI_36164, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75768 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78804 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_84981 ] . obo:CHEBI_37054 obo:IAO_0000115 "A hydroxy fatty acid anion that is the conjugate base of 3-hydroxybutyric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C4H7O3" ; chebi:inchi "InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1" ; chebi:inchikey "WHBMMWSBFZVSSR-UHFFFAOYSA-M" ; chebi:mass "103.09658" ; chebi:monoisotopicmass "103.04007" ; chebi:smiles "CC(O)CC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:4127635", "Reaxys:4127635" ; oboInOwl:hasExactSynonym "3-hydroxybutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-OH butyrate", "3-OH-butyrate", "3-hydroxybutanoate", "DL-3-hydroxybutyrate", "beta-hydroxy-n-butyrate", "beta-hydroxybutanoate" ; oboInOwl:id "CHEBI:37054" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxybutyrate" ; rdfs:subClassOf obo:CHEBI_84196, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17968 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_20067 ] . obo:CHEBI_37142 obo:IAO_0000115 "An organoiodine compound is a compound containing at least one carbon-iodine bond." ; chebi:charge "0" ; chebi:formula "IR" ; chebi:mass "126.904" ; chebi:monoisotopicmass "126.90447" ; chebi:smiles "*I" ; oboInOwl:hasDbXref "MetaCyc:Organoiodine-Compounds", "Wikipedia:Organoiodine_compound" ; oboInOwl:hasExactSynonym "organoiodine compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organoiodine compounds" ; oboInOwl:id "CHEBI:37142" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organoiodine compound" ; rdfs:subClassOf obo:CHEBI_17792, obo:CHEBI_24860 . obo:CHEBI_37163 obo:IAO_0000115 "A polysaccharide composed of glucose residues." ; chebi:formula "C12H22O11(C6H10O5)n" ; oboInOwl:hasAlternativeId "CHEBI:24255", "CHEBI:5392" ; oboInOwl:hasDbXref "CAS:9037-91-6", "KEGG:C01379" ; oboInOwl:hasExactSynonym "Glucan", "glucan" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glucans" ; oboInOwl:id "CHEBI:37163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucan" ; rdfs:subClassOf obo:CHEBI_37164 . obo:CHEBI_37164 obo:IAO_0000115 "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." ; oboInOwl:hasExactSynonym "homopolysaccharide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "homoglycan", "homopolysaccharides" ; oboInOwl:id "CHEBI:37164" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homopolysaccharide" ; rdfs:subClassOf obo:CHEBI_18154 . obo:CHEBI_37175 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic hydrides" ; oboInOwl:id "CHEBI:37175" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic hydride" ; rdfs:subClassOf obo:CHEBI_33692 . obo:CHEBI_37176 oboInOwl:hasExactSynonym "mononuclear parent hydrides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mononuclear hydride", "mononuclear hydrides" ; oboInOwl:id "CHEBI:37176" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mononuclear parent hydride" ; rdfs:subClassOf obo:CHEBI_33692 . obo:CHEBI_37246 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:37246" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental sodium" ; rdfs:subClassOf obo:CHEBI_26712 . obo:CHEBI_37247 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:37247" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental potassium" ; rdfs:subClassOf obo:CHEBI_26217 . obo:CHEBI_37257 obo:IAO_0000115 "A branched-chain saturated fatty acid anion that is the conjugate base of phytanic acid, arising from deprotonation of the carboxylic acid group." ; chebi:charge "-1" ; chebi:formula "C20H39O2" ; chebi:inchi "InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1" ; chebi:inchikey "RLCKHJSFHOZMDR-UHFFFAOYSA-M" ; chebi:mass "311.52246" ; chebi:monoisotopicmass "311.29555" ; chebi:smiles "CC(C)CCCC(C)CCCC(C)CCCC(C)CC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:14834", "CHEBI:26109" ; oboInOwl:hasDbXref "Beilstein:3669982", "KEGG:C01607", "PMID:5130448", "Reaxys:3669982" ; oboInOwl:hasExactSynonym "3,7,11,15-tetramethylhexadecanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,7,11,15-tetramethylhexadecanoate", "3,7,11,15-tetramethylpalmitate", "phytanate anion" ; oboInOwl:id "CHEBI:37257" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phytanate" ; rdfs:subClassOf obo:CHEBI_57560, obo:CHEBI_58956, obo:CHEBI_83972, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15756 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_7896 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16285 ] . obo:CHEBI_37395 obo:IAO_0000115 "Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid." ; oboInOwl:hasAlternativeId "CHEBI:25425", "CHEBI:7011" ; oboInOwl:hasDbXref "KEGG:C05114" ; oboInOwl:hasExactSynonym "Mucopolysaccharide", "mucopolysaccharides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Mucopolysaccharid", "Mukopolysaccharid", "mucopolisacarido", "mucopolisacaridos" ; oboInOwl:id "CHEBI:37395" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mucopolysaccharide" ; rdfs:subClassOf obo:CHEBI_18085 . obo:CHEBI_37397 obo:IAO_0000115 "Any of a class of 10--60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues." ; oboInOwl:hasAlternativeId "CHEBI:23224", "CHEBI:3676" ; oboInOwl:hasDbXref "CAS:9007-28-7", "KEGG:C00607", "PMID:11514091", "PMID:7538297" ; oboInOwl:hasExactSynonym "Chondroitin sulfate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chondroitinsulfat", "chondroitin polysulfate", "chondroitin sulfates", "chondroitin sulfuric acid", "chondroitin sulphate" ; oboInOwl:id "CHEBI:37397" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chondroitin sulfate" ; rdfs:subClassOf obo:CHEBI_35722, obo:CHEBI_37395, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16137 ] . obo:CHEBI_37445 obo:IAO_0000115 "A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid units." ; oboInOwl:hasAlternativeId "CHEBI:24074", "CHEBI:24076" ; oboInOwl:hasExactSynonym "folates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "folate", "folates" ; oboInOwl:id "CHEBI:37445" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "folic acids" ; rdfs:subClassOf obo:CHEBI_176842, obo:CHEBI_26375, obo:CHEBI_83982, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_67011 ] . obo:CHEBI_37527 obo:IAO_0000115 "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." ; oboInOwl:hasAlternativeId "CHEBI:13800", "CHEBI:13801", "CHEBI:22209", "CHEBI:2426" ; oboInOwl:hasDbXref "KEGG:C00174" ; oboInOwl:hasExactSynonym "Acid", "acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Saeure", "Saeuren", "acide", "acido", "acids" ; oboInOwl:id "CHEBI:37527" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acid" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_37577 obo:IAO_0000115 "A molecular entity consisting of two or more chemical elements." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chemical compound", "heteroatomic molecular entities" ; oboInOwl:id "CHEBI:37577" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heteroatomic molecular entity" ; rdfs:subClassOf obo:CHEBI_36357 . obo:CHEBI_37578 obo:IAO_0000115 "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." ; oboInOwl:hasDbXref "Wikipedia:Halide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "halides" ; oboInOwl:id "CHEBI:37578" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "halide" ; rdfs:subClassOf obo:CHEBI_24471, obo:CHEBI_37577 . obo:CHEBI_37622 obo:IAO_0000115 "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." ; chebi:charge "0" ; chebi:formula "CNOR3" ; chebi:mass "42.01680" ; chebi:monoisotopicmass "41.99799" ; chebi:smiles "[*]C(=O)N([*])[*]" ; oboInOwl:hasAlternativeId "CHEBI:35354", "CHEBI:35355" ; oboInOwl:hasExactSynonym "carboxamides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carboxamides", "primary carboxamide" ; oboInOwl:id "CHEBI:37622" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxamide" ; rdfs:subClassOf obo:CHEBI_33256, obo:CHEBI_35352, obo:CHEBI_36963, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_23004 ] . obo:CHEBI_37624 chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasDbXref "Beilstein:1724626", "CAS:921-60-8" ; oboInOwl:hasExactSynonym "L-gluco-hexose", "L-glucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L(-)-glucose" ; oboInOwl:id "CHEBI:37624" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glucose" ; rdfs:subClassOf obo:CHEBI_17234 . obo:CHEBI_37627 obo:IAO_0000115 "The L-enantiomer of glucopyranose." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m0/s1" ; chebi:inchikey "WQZGKKKJIJFFOK-ZZWDRFIYSA-N" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; chebi:smiles "OC[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@H]1O" ; oboInOwl:hasDbXref "Beilstein:2206321", "GlyGen:G16038XU", "GlyTouCan:G16038XU", "Reaxys:2206321" ; oboInOwl:hasExactSynonym "L-glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/" ; oboInOwl:id "CHEBI:37627" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glucopyranose" ; rdfs:subClassOf obo:CHEBI_37624, obo:CHEBI_37661 . obo:CHEBI_37631 obo:IAO_0000115 "A L-glucopyranose with a beta-configuration at the anomeric position." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m0/s1" ; chebi:inchikey "WQZGKKKJIJFFOK-QYESYBIKSA-N" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; chebi:smiles "OC[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O" ; oboInOwl:hasDbXref "Beilstein:1907373", "GlyGen:G59396XU", "GlyTouCan:G59396XU", "Reaxys:1907373" ; oboInOwl:hasExactSynonym "beta-L-glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "WURCS=2.0/1,1,0/[a1211h-1b_1-5]/1/" ; oboInOwl:id "CHEBI:37631" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-L-glucose" ; rdfs:subClassOf obo:CHEBI_37627, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_15903 ] . obo:CHEBI_37661 chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasExactSynonym "glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:37661" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glucopyranose" ; rdfs:subClassOf obo:CHEBI_17234 . obo:CHEBI_37684 obo:IAO_0000115 "An aldohexose that is the C-2 epimer of glucose." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasAlternativeId "CHEBI:14575", "CHEBI:33930" ; oboInOwl:hasDbXref "PMID:16180318", "PMID:24407290" ; oboInOwl:hasExactSynonym "manno-hexose", "mannose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Man" ; oboInOwl:id "CHEBI:37684" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mannose" ; rdfs:subClassOf obo:CHEBI_33917, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ] . obo:CHEBI_37734 oboInOwl:hasAlternativeId "CHEBI:26019" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:37734" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "phosphoric ester" ; rdfs:subClassOf obo:CHEBI_26079, obo:CHEBI_35701 . obo:CHEBI_37786 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acyclic phosphorus acid anhydrides" ; oboInOwl:id "CHEBI:37786" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "acyclic phosphorus acid anhydride" ; rdfs:subClassOf obo:CHEBI_36608 . obo:CHEBI_37793 obo:IAO_0000115 "An organosulfonic acid containing one or more amino groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino sulfonic acids", "aminosulfonic acid", "aminosulfonic acids" ; oboInOwl:id "CHEBI:37793" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino sulfonic acid" ; rdfs:subClassOf obo:CHEBI_33551, obo:CHEBI_50047 . obo:CHEBI_37808 obo:IAO_0000115 "A straight chain alkane composed of 4 carbon atoms." ; chebi:charge "0" ; chebi:formula "C4H10" ; chebi:inchi "InChI=1S/C4H10/c1-3-4-2/h3-4H2,1-2H3" ; chebi:inchikey "IJDNQMDRQITEOD-UHFFFAOYSA-N" ; chebi:mass "58.12220" ; chebi:monoisotopicmass "58.07825" ; chebi:smiles "CCCC" ; oboInOwl:hasAlternativeId "CHEBI:22945", "CHEBI:25462", "CHEBI:44430" ; oboInOwl:hasDbXref "Beilstein:969129", "CAS:106-97-8", "Gmelin:1148", "PDBeChem:NBU", "PMID:24179026", "Reaxys:969129", "Wikipedia:Butane" ; oboInOwl:hasExactSynonym "butane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "E 943a", "E-943a", "E943a", "N-BUTANE", "R-600", "n-Butan", "n-C4H10", "n-butane" ; oboInOwl:id "CHEBI:37808" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "butane" ; rdfs:subClassOf obo:CHEBI_138675, obo:CHEBI_18310, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78433 ] . obo:CHEBI_37826 oboInOwl:hasExactSynonym "sulfuric acid derivative" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfuric acid derivatives" ; oboInOwl:id "CHEBI:37826" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfuric acid derivative" ; rdfs:subClassOf obo:CHEBI_33424, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_26836 ] . obo:CHEBI_37838 obo:IAO_0000115 "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." ; oboInOwl:hasExactSynonym "carboacyl groups", "carboxylic acyl group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carboxylic acyl groups" ; oboInOwl:id "CHEBI:37838" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboacyl group" ; rdfs:subClassOf obo:CHEBI_22221, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_33575 ] . obo:CHEBI_37848 obo:IAO_0000115 "A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds." ; oboInOwl:hasAlternativeId "CHEBI:26158" ; oboInOwl:hasDbXref "Wikipedia:Phytohormone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "phytohormone", "phytohormones", "plant growth factor", "plant growth factors", "plant growth hormone", "plant growth hormones", "plant hormones" ; oboInOwl:id "CHEBI:37848" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "plant hormone" ; rdfs:subClassOf obo:CHEBI_24621, obo:CHEBI_26155 . obo:CHEBI_37886 obo:IAO_0000115 "An agent that selectively binds to and activates adrenergic receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "adrenergic agonists", "adrenergic receptor agonist", "adrenoceptor agonists", "adrenomimetic", "adrenomimetics" ; oboInOwl:id "CHEBI:37886" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "adrenergic agonist" ; rdfs:subClassOf obo:CHEBI_37962 . obo:CHEBI_37962 obo:IAO_0000115 "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "adrenergic agents", "adrenergic drug", "adrenergic drugs", "adrenergic neuron agents", "adrenergics" ; oboInOwl:id "CHEBI:37962" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "adrenergic agent" ; rdfs:subClassOf obo:CHEBI_35942 . obo:CHEBI_38077 obo:IAO_0000115 "A compound composed of two or more pyrrole units." ; oboInOwl:hasDbXref "Beilstein:8538310" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "PPys", "poly(pyrrole)s", "polypyrroles" ; oboInOwl:id "CHEBI:38077" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polypyrrole" ; rdfs:subClassOf obo:CHEBI_38101 . obo:CHEBI_38101 obo:IAO_0000115 "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heterocyclic organonitrogen compounds", "organonitrogen heterocyclic compounds" ; oboInOwl:id "CHEBI:38101" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organonitrogen heterocyclic compound" ; rdfs:subClassOf obo:CHEBI_24532, obo:CHEBI_35352 . obo:CHEBI_38104 obo:IAO_0000115 "Any organic heterocyclic compound containing at least one ring oxygen atom." ; oboInOwl:hasDbXref "PMID:17134300" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "heterocyclic organooxygen compounds", "organooxygen heterocyclic compounds", "oxacycles" ; oboInOwl:id "CHEBI:38104" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxacycle" ; rdfs:subClassOf obo:CHEBI_24532, obo:CHEBI_36963 . obo:CHEBI_38147 obo:IAO_0000115 "A drug that has a strengthening effect on the heart or that can increase cardiac output." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cardiotonic drugs" ; oboInOwl:id "CHEBI:38147" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cardiotonic drug" ; rdfs:subClassOf obo:CHEBI_35554 . obo:CHEBI_38161 obo:IAO_0000115 "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." ; oboInOwl:hasAlternativeId "CHEBI:23090", "CHEBI:3585", "CHEBI:6789" ; oboInOwl:hasDbXref "KEGG:C00917", "KEGG:C02169" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chelating agent", "Metal chelator", "chelating agents", "chelators", "complexon" ; oboInOwl:id "CHEBI:38161" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chelator" ; rdfs:subClassOf obo:CHEBI_52214 . obo:CHEBI_38166 oboInOwl:hasAlternativeId "CHEBI:25429", "CHEBI:38075" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic heteropolycyclic compounds" ; oboInOwl:id "CHEBI:38166" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic heteropolycyclic compound" ; rdfs:subClassOf obo:CHEBI_24532, obo:CHEBI_33671 . obo:CHEBI_38179 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monocyclic heteroarenes" ; oboInOwl:id "CHEBI:38179" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monocyclic heteroarene" ; rdfs:subClassOf obo:CHEBI_33833 . obo:CHEBI_38180 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polycyclic heteroarenes" ; oboInOwl:id "CHEBI:38180" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polycyclic heteroarene" ; rdfs:subClassOf obo:CHEBI_33833 . obo:CHEBI_38260 obo:IAO_0000115 "Any of a class of heterocyclic amines having a saturated five-membered ring." ; oboInOwl:hasAlternativeId "CHEBI:26922", "CHEBI:38191" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38260" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidines" ; rdfs:subClassOf obo:CHEBI_25693, obo:CHEBI_38101 . obo:CHEBI_38261 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38261" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidazolidines" ; rdfs:subClassOf obo:CHEBI_38304 . obo:CHEBI_38263 obo:IAO_0000115 "An alpha-amino acid that is butanoic acid substituted by an amino group at position 2 and a hydroxy group at position 3." ; chebi:charge "0" ; chebi:formula "C4H9NO3" ; chebi:inchi "InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)" ; chebi:inchikey "AYFVYJQAPQTCCC-UHFFFAOYSA-N" ; chebi:mass "119.11920" ; chebi:monoisotopicmass "119.05824" ; chebi:smiles "CC(O)C(N)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:1098902" ; oboInOwl:hasExactSynonym "2-amino-3-hydroxybutanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38263" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-amino-3-hydroxybutanoic acid" ; rdfs:subClassOf obo:CHEBI_33704, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ] . obo:CHEBI_38264 obo:IAO_0000115 "A branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2." ; chebi:charge "0" ; chebi:formula "C6H13NO2" ; chebi:inchi "InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)" ; chebi:inchikey "AGPKZVBTJJNPAG-UHFFFAOYSA-N" ; chebi:mass "131.17296" ; chebi:monoisotopicmass "131.09463" ; chebi:smiles "CCC(C)C(N)C(O)=O" ; oboInOwl:hasDbXref "CAS:443-79-8", "KEGG:C16434", "PMID:10944265", "Reaxys:1721790" ; oboInOwl:hasExactSynonym "2-amino-3-methylpentanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38264" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-amino-3-methylpentanoic acid" ; rdfs:subClassOf obo:CHEBI_22918, obo:CHEBI_33704 . obo:CHEBI_38275 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrrolidinones" ; oboInOwl:id "CHEBI:38275" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidinone" ; rdfs:subClassOf obo:CHEBI_38260 . obo:CHEBI_38304 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "diazolidines" ; oboInOwl:id "CHEBI:38304" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diazolidine" ; rdfs:subClassOf obo:CHEBI_25693, obo:CHEBI_38101 . obo:CHEBI_38313 obo:IAO_0000115 "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diazines" ; rdfs:subClassOf obo:CHEBI_25693, obo:CHEBI_38101 . obo:CHEBI_38316 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrimidinecarboxylate anions" ; oboInOwl:id "CHEBI:38316" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidinecarboxylate anion" ; rdfs:subClassOf obo:CHEBI_35757 . obo:CHEBI_38323 obo:IAO_0000115 "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cholinergic agent", "cholinergic drugs", "cholinomimetic" ; oboInOwl:id "CHEBI:38323" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholinergic drug" ; rdfs:subClassOf obo:CHEBI_35942 . obo:CHEBI_38337 obo:IAO_0000115 "A pyrimidine carrying one or more oxo substituents." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrimidones" ; oboInOwl:id "CHEBI:38337" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidone" ; rdfs:subClassOf obo:CHEBI_39447 . obo:CHEBI_38443 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-benzopyrans" ; oboInOwl:id "CHEBI:38443" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1-benzopyran" ; rdfs:subClassOf obo:CHEBI_22727 . obo:CHEBI_38496 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38496" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "electron-transport chain inhibitor" ; rdfs:subClassOf obo:CHEBI_76932 . obo:CHEBI_38497 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38497" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "respiratory-chain inhibitor" ; rdfs:subClassOf obo:CHEBI_38496 . obo:CHEBI_38560 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "simple proteins" ; oboInOwl:id "CHEBI:38560" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "simple protein" ; rdfs:subClassOf obo:CHEBI_36080 . obo:CHEBI_38631 oboInOwl:hasAlternativeId "CHEBI:22503", "CHEBI:24792" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aminoalkylindoles" ; oboInOwl:id "CHEBI:38631" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aminoalkylindole" ; rdfs:subClassOf obo:CHEBI_24828 . obo:CHEBI_38632 obo:IAO_0000115 "Any agent that affects the transport of molecular entities across a biological membrane." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "membrane transport modulators" ; oboInOwl:id "CHEBI:38632" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "membrane transport modulator" ; rdfs:subClassOf obo:CHEBI_52208 . obo:CHEBI_38700 oboInOwl:hasExactSynonym "organic sodium salt" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic sodium salts" ; oboInOwl:id "CHEBI:38700" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic sodium salt" ; rdfs:subClassOf obo:CHEBI_24868, obo:CHEBI_26714 . obo:CHEBI_38716 obo:IAO_0000115 "Any dianion containing at least one carboxy group." ; oboInOwl:hasExactSynonym "carboxylic acid dianion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carboxylic acid dianions" ; oboInOwl:id "CHEBI:38716" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxylic acid dianion" ; rdfs:subClassOf obo:CHEBI_29067 . obo:CHEBI_38717 obo:IAO_0000115 "A trianion containing at least one carboxy group." ; oboInOwl:hasExactSynonym "carboxylic acid trianion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carboxylic acid trianions" ; oboInOwl:id "CHEBI:38717" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxylic acid trianion" ; rdfs:subClassOf obo:CHEBI_29067 . obo:CHEBI_38793 chebi:charge "0" ; chebi:formula "C14H11N6O3" ; chebi:mass "311.276" ; chebi:monoisotopicmass "311.08926" ; oboInOwl:hasAlternativeId "CHEBI:37074" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38793" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pteroate" ; rdfs:subClassOf obo:CHEBI_38796, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_38794 ] . obo:CHEBI_38794 chebi:charge "0" ; chebi:formula "C14H12N6O3" ; chebi:mass "312.284" ; chebi:monoisotopicmass "312.09709" ; oboInOwl:hasAlternativeId "CHEBI:26378" ; oboInOwl:hasDbXref "CAS:119-24-4", "DrugBank:DB04196" ; oboInOwl:hasExactSynonym "Pteroic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Pteroinsaeure" ; oboInOwl:id "CHEBI:38794" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pteroic acid" ; rdfs:subClassOf obo:CHEBI_38795, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_38793 ] . obo:CHEBI_38795 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38795" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pteroic acids" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_26375 . obo:CHEBI_38796 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:38796" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pteroates" ; rdfs:subClassOf obo:CHEBI_22494, obo:CHEBI_35757 . obo:CHEBI_38807 obo:IAO_0000115 "Agents that increase calcium influx into calcium channels of excitable tissues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "calcium channel activator", "calcium channel activators", "calcium channel agonists" ; oboInOwl:id "CHEBI:38807" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calcium channel agonist" ; rdfs:subClassOf obo:CHEBI_38808 . obo:CHEBI_38808 obo:IAO_0000115 "A membrane transport modulator that is able to regulate intracellular calcium levels." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "calcium channel modulators" ; oboInOwl:id "CHEBI:38808" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "calcium channel modulator" ; rdfs:subClassOf obo:CHEBI_38632 . obo:CHEBI_38856 oboInOwl:hasExactSynonym "halophenol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "halophenols" ; oboInOwl:id "CHEBI:38856" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "halophenol" ; rdfs:subClassOf obo:CHEBI_17792, obo:CHEBI_33853 . obo:CHEBI_38867 obo:IAO_0000115 "Substance which produces loss of feeling or sensation." ; oboInOwl:hasExactSynonym "anaesthetic" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Anaesthetika", "Anaesthetikum", "anaesthetics", "anesthetic agent", "anesthetic drug", "anesthetics" ; oboInOwl:id "CHEBI:38867" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anaesthetic" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_3892 obo:IAO_0000115 "A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency." ; chebi:charge "0" ; chebi:formula "C207H308N56O58S" ; chebi:inchi "InChI=1S/C207H308N56O58S/c1-108(2)89-140(186(302)240-135(69-74-163(279)280)182(298)254-149(204(320)321)94-117-43-20-15-21-44-117)250-193(309)152-54-35-86-262(152)202(318)147(92-116-41-18-14-19-42-116)252-171(287)114(11)230-175(291)132(66-71-160(273)274)234-170(286)113(10)231-191(307)150(105-265)255-183(299)136(70-75-164(281)282)241-190(306)146(98-165(283)284)249-180(296)133(67-72-161(275)276)235-169(285)112(9)229-157(270)101-225-174(290)145(97-156(213)269)251-194(310)153-55-36-87-263(153)203(319)148(93-119-60-64-123(268)65-61-119)253-199(315)167(110(5)6)257-185(301)129(49-26-30-79-210)243-198(314)168(111(7)8)259-196(312)155-57-38-85-261(155)201(317)139(53-34-83-223-207(218)219)244-178(294)130(51-32-81-221-205(214)215)237-177(293)128(48-25-29-78-209)236-176(292)127(47-24-28-77-208)232-158(271)103-227-197(313)166(109(3)4)258-195(311)154-56-37-84-260(154)200(316)138(50-27-31-80-211)233-159(272)102-226-173(289)143(95-120-99-224-126-46-23-22-45-124(120)126)247-179(295)131(52-33-82-222-206(216)217)238-187(303)142(90-115-39-16-13-17-40-115)246-189(305)144(96-121-100-220-107-228-121)248-181(297)134(68-73-162(277)278)239-184(300)137(76-88-322-12)242-192(308)151(106-266)256-188(304)141(245-172(288)125(212)104-264)91-118-58-62-122(267)63-59-118/h13-23,39-46,58-65,99-100,107-114,125,127-155,166-168,224,264-268H,24-38,47-57,66-98,101-106,208-212H2,1-12H3,(H2,213,269)(H,220,228)(H,225,290)(H,226,289)(H,227,313)(H,229,270)(H,230,291)(H,231,307)(H,232,271)(H,233,272)(H,234,286)(H,235,285)(H,236,292)(H,237,293)(H,238,303)(H,239,300)(H,240,302)(H,241,306)(H,242,308)(H,243,314)(H,244,294)(H,245,288)(H,246,305)(H,247,295)(H,248,297)(H,249,296)(H,250,309)(H,251,310)(H,252,287)(H,253,315)(H,254,298)(H,255,299)(H,256,304)(H,257,301)(H,258,311)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,320,321)(H4,214,215,221)(H4,216,217,222)(H4,218,219,223)/t112-,113-,114-,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,166-,167-,168-/m0/s1" ; chebi:inchikey "IDLFZVILOHSSID-OVLDLUHVSA-N" ; chebi:mass "4541.06600" ; chebi:monoisotopicmass "4538.25937" ; chebi:smiles "CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O" ; oboInOwl:hasDbXref "CAS:9002-60-2", "DrugBank:DB01285", "Drug_Central:4931", "KEGG:C02017", "KEGG:D00146" ; oboInOwl:hasExactSynonym "Corticotropin", "L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ACTH", "Adrenocorticotropic hormone", "SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF", "adrenocorticotropin", "corticotrofina", "corticotrophine", "corticotrophinum", "corticotropin", "cortrophin" ; oboInOwl:id "CHEBI:3892" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "corticotropin" ; rdfs:subClassOf obo:CHEBI_15841, obo:CHEBI_25905, obo:CHEBI_33694, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33295 ] . obo:CHEBI_38958 obo:IAO_0000115 "An alkaloid containing an indole skeleton." ; oboInOwl:hasAlternativeId "CHEBI:24795", "CHEBI:5901" ; oboInOwl:hasDbXref "KEGG:C06073", "Wikipedia:Indole_alkaloid" ; oboInOwl:hasExactSynonym "Indole alkaloid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "indole alkaloids" ; oboInOwl:id "CHEBI:38958" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "indole alkaloid" ; rdfs:subClassOf obo:CHEBI_22315, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_73398 ] . obo:CHEBI_38975 obo:IAO_0000115 "Any alkylbenzene that is benzene substituted with one or more methyl groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methylbenzenes" ; oboInOwl:id "CHEBI:38975" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylbenzene" ; rdfs:subClassOf obo:CHEBI_38976 . obo:CHEBI_38976 obo:IAO_0000115 "A monocyclic arene that is benzene substituted with one or more alkyl groups." ; oboInOwl:hasExactSynonym "alkylbenzene" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alkylbenzol", "alkylbenzenes" ; oboInOwl:id "CHEBI:38976" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkylbenzene" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_33847, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_16716 ] . obo:CHEBI_39015 obo:IAO_0000115 "Protein component on the surface of lipoprotein." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "apolipoproteins" ; oboInOwl:id "CHEBI:39015" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "apolipoprotein" ; rdfs:subClassOf obo:CHEBI_13850 . obo:CHEBI_39022 obo:IAO_0000115 "A complex in which one component (the host) forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species (the guest) are located. There is no covalent bonding between guest and host, the attraction being generally due to van der Waals forces." ; oboInOwl:hasExactSynonym "inclusion compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "compose d'inclusion", "compuesto de inclusion", "compuestos de inclusion", "inclusion complex", "inclusion compounds" ; oboInOwl:id "CHEBI:39022" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "inclusion compound" ; rdfs:subClassOf obo:CHEBI_50967 . obo:CHEBI_39024 obo:IAO_0000115 "Inclusion compound in which the guest molecule is in a cage formed by the host molecule or by a lattice of host molecules." ; oboInOwl:hasExactSynonym "clathrates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Clathrat", "Clathratverbindung", "Klathrat", "Klathratverbindung", "cage compound", "clathrate", "clathrate compounds", "clatrato", "clatratos", "compuesto de clatrato" ; oboInOwl:id "CHEBI:39024" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "clathrate compound" ; rdfs:subClassOf obo:CHEBI_39022 . obo:CHEBI_39026 obo:IAO_0000115 "A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease." ; oboInOwl:hasDbXref "PMID:11082530", "PMID:15583011", "PMID:15913955", "PMID:19349632", "PMID:28401639", "PMID:28432662", "PMID:28792690", "PMID:28827781", "PMID:28847800", "PMID:28859941", "PMID:28870972", "Wikipedia:Low-density_lipoprotein" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "LDL", "beta-lipoproteins", "low-density lipoproteins" ; oboInOwl:id "CHEBI:39026" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "low-density lipoprotein" ; rdfs:subClassOf obo:CHEBI_6495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_47774 ] . obo:CHEBI_39141 obo:IAO_0000115 "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." ; oboInOwl:hasExactSynonym "Bronsted acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Bronsted-Saeure", "acide de Bronsted", "donneur d'hydron", "hydron donor" ; oboInOwl:id "CHEBI:39141" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Bronsted acid" ; rdfs:subClassOf obo:CHEBI_17891, obo:CHEBI_37527 . obo:CHEBI_39142 obo:IAO_0000115 "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." ; oboInOwl:hasExactSynonym "Bronsted base" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Bronsted-Base", "accepteur d'hydron", "base de Bronsted", "hydron acceptor" ; oboInOwl:id "CHEBI:39142" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Bronsted base" ; rdfs:subClassOf obo:CHEBI_15339, obo:CHEBI_22695 . obo:CHEBI_39144 obo:IAO_0000115 "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." ; oboInOwl:hasExactSynonym "Lewis base" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Lewis-Base", "base de Lewis", "donneur d'une paire d'electrons", "electron donor" ; oboInOwl:id "CHEBI:39144" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Lewis base" ; rdfs:subClassOf obo:CHEBI_17891, obo:CHEBI_22695 . obo:CHEBI_39150 obo:IAO_0000115 "A member of the class of oxopentanoates that is the conjugate base of 4-oxopentanoic acid." ; chebi:charge "-1" ; chebi:formula "C5H7O3" ; chebi:inchi "InChI=1S/C5H8O3/c1-4(6)2-3-5(7)8/h2-3H2,1H3,(H,7,8)/p-1" ; chebi:inchikey "JOOXCMJARBKPKM-UHFFFAOYSA-M" ; chebi:mass "115.10728" ; chebi:monoisotopicmass "115.04007" ; chebi:smiles "CC(=O)CCC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3537533", "Gmelin:325844", "MetaCyc:CPD-16942", "Reaxys:3537533" ; oboInOwl:hasExactSynonym "4-oxopentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-acetylpropionate", "4-ketovalerate", "4-oxovalerate", "beta-acetylpropionate", "gamma-ketovalerate", "laevulinate", "levulate", "levulinate" ; oboInOwl:id "CHEBI:39150" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-oxopentanoate" ; rdfs:subClassOf obo:CHEBI_25798, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_45630 ] . obo:CHEBI_39317 obo:IAO_0000115 "Any chemical substance that inhibits the life-cycle of an organism." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "growth regulators" ; oboInOwl:id "CHEBI:39317" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "growth regulator" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_39417 obo:IAO_0000115 "Any saturated fatty acid with a carbon side-chain or isopropyl termination." ; oboInOwl:hasExactSynonym "branched-chain saturated fatty acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "branched saturated fatty acid", "branched saturated fatty acids", "branched-chain saturated fatty acids" ; oboInOwl:id "CHEBI:39417" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain saturated fatty acid" ; rdfs:subClassOf obo:CHEBI_26607, obo:CHEBI_35819, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58956 ] . obo:CHEBI_39418 obo:IAO_0000115 "Any saturated fatty acid lacking a side-chain." ; oboInOwl:hasDbXref "PMID:15644336" ; oboInOwl:hasExactSynonym "straight-chain saturated fatty acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "straight-chain saturated fatty acids" ; oboInOwl:id "CHEBI:39418" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "straight-chain saturated fatty acid" ; rdfs:subClassOf obo:CHEBI_26607, obo:CHEBI_59202, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_58954 ] . obo:CHEBI_39447 obo:IAO_0000115 "Any compound having a pyrimidine as part of its structure." ; oboInOwl:hasAlternativeId "CHEBI:13681", "CHEBI:26448" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:39447" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidines" ; rdfs:subClassOf obo:CHEBI_38313 . obo:CHEBI_39745 obo:IAO_0000115 "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." ; chebi:charge "-1" ; chebi:formula "H2O4P" ; chebi:inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1" ; chebi:inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-M" ; chebi:mass "96.98724" ; chebi:monoisotopicmass "96.96962" ; chebi:smiles "[H]OP([O-])(=O)O[H]" ; oboInOwl:hasAlternativeId "CHEBI:29137", "CHEBI:39739" ; oboInOwl:hasDbXref "DrugBank:DB02831", "Gmelin:1999", "PDBeChem:2HP" ; oboInOwl:hasExactSynonym "dihydrogen(tetraoxidophosphate)(1-)", "dihydrogenphosphate", "dihydrogentetraoxophosphate(1-)", "dihydrogentetraoxophosphate(V)", "dihydroxidodioxidophosphate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "DIHYDROGENPHOSPHATE ION", "H2PO4(-)", "[PO2(OH)2](-)" ; oboInOwl:id "CHEBI:39745" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dihydrogenphosphate" ; rdfs:subClassOf obo:CHEBI_35780, obo:CHEBI_79389, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_43474 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26078 ] . obo:CHEBI_3992 oboInOwl:hasDbXref "KEGG:C02019" ; oboInOwl:hasExactSynonym "Cyclic ketone", "cyclic ketones" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:3992" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic ketone" ; rdfs:subClassOf obo:CHEBI_17087 . obo:CHEBI_40751 obo:IAO_0000115 "The S-enantiomer of adrenaline." ; chebi:charge "0" ; chebi:formula "C9H13NO3" ; chebi:inchi "InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m1/s1" ; chebi:inchikey "UCTWMZQNUQWSLP-SECBINFHSA-N" ; chebi:mass "183.20446" ; chebi:monoisotopicmass "183.08954" ; chebi:smiles "CNC[C@@H](O)c1ccc(O)c(O)c1" ; oboInOwl:hasAlternativeId "CHEBI:30615", "CHEBI:40743" ; oboInOwl:hasDbXref "Beilstein:2938799", "CAS:150-05-0", "PDBeChem:ALE", "Reaxys:2938799" ; oboInOwl:hasExactSynonym "(S)-adrenaline", "4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol", "(+)-adrenaline", "(S)-(+)-adrenaline", "(S)-4-(1-hydroxy-2-(methylamino)ethyl)pyrocatechol", "d-adrenaline", "d-epinephrine" ; oboInOwl:id "CHEBI:40751" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-adrenaline" ; rdfs:subClassOf obo:CHEBI_194548, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_28918 ] . obo:CHEBI_41402 chebi:charge "0" ; chebi:formula "C2H3O2" ; chebi:mass "59.04402" ; chebi:monoisotopicmass "59.01330" ; chebi:smiles "O=C(C*)O" ; oboInOwl:hasAlternativeId "CHEBI:23029", "CHEBI:41396" ; oboInOwl:hasDbXref "PDBeChem:ACY" ; oboInOwl:hasExactSynonym "CARBOXYMETHYL GROUP", "carboxymethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-CH2-COOH", "aspartic acid side-chain" ; oboInOwl:id "CHEBI:41402" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxymethyl group" ; rdfs:subClassOf obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_15366 ] . obo:CHEBI_41609 chebi:charge "-2" ; chebi:formula "CO3" ; chebi:inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2" ; chebi:inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-L" ; chebi:mass "60.00890" ; chebi:monoisotopicmass "59.98584" ; chebi:smiles "[O-]C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:29201", "CHEBI:41605" ; oboInOwl:hasDbXref "Beilstein:3600898", "CAS:3812-32-6", "Gmelin:1559", "PDBeChem:CO3" ; oboInOwl:hasExactSynonym "carbonate", "trioxidocarbonate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CARBONATE ION", "CO3(2-)", "Karbonat", "[CO3](2-)" ; oboInOwl:id "CHEBI:41609" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbonate" ; rdfs:subClassOf obo:CHEBI_35604, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17544 ] . obo:CHEBI_4167 obo:IAO_0000115 "A glucopyranose having D-configuration." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1" ; chebi:inchikey "WQZGKKKJIJFFOK-GASJEMHNSA-N" ; chebi:mass "180.15588" ; chebi:monoisotopicmass "180.06339" ; chebi:smiles "OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O" ; oboInOwl:hasDbXref "Beilstein:1281604", "CAS:2280-44-6", "GlyGen:G15021LG", "GlyTouCan:G15021LG", "Gmelin:83256", "HMDB:HMDB0000122", "KEGG:C00031", "KEGG:D00009", "KNApSAcK:C00001122", "MetaCyc:D-Glucose", "PMID:15987845", "PMID:16901854", "PMID:17336832", "PMID:17439666", "PMID:17928662", "PMID:19913595", "PMID:26812026", "PMID:32619908", "PMID:7524207", "PMID:9140037", "PMID:9501190", "PMID:9506998", "PMID:9545565", "Reaxys:1281604", "Wikipedia:Glucose" ; oboInOwl:hasExactSynonym "D-glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-Glc", "D-Glcp", "D-Glucose", "D-glucose", "Dextrose", "Glc-OH", "Glucose", "Grape sugar", "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/", "glucose" ; oboInOwl:id "CHEBI:4167" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-glucopyranose" ; rdfs:subClassOf obo:CHEBI_17634, obo:CHEBI_37661, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_41808 obo:IAO_0000115 "A straight-chain alkane with 10 carbon atoms." ; chebi:charge "0" ; chebi:formula "C10H22" ; chebi:inchi "InChI=1S/C10H22/c1-3-5-7-9-10-8-6-4-2/h3-10H2,1-2H3" ; chebi:inchikey "DIOQZVSQGTUSAI-UHFFFAOYSA-N" ; chebi:mass "142.28168" ; chebi:monoisotopicmass "142.17215" ; chebi:smiles "CCCCCCCCCC" ; oboInOwl:hasAlternativeId "CHEBI:32894", "CHEBI:41801" ; oboInOwl:hasDbXref "Beilstein:1696981", "CAS:124-18-5", "DrugBank:DB02826", "Gmelin:67816", "HMDB:HMDB0031450", "LIPID_MAPS_instance:LMFA11000568", "MetaCyc:CPD-9287", "PDBeChem:D10", "PMID:11762597", "Reaxys:1696981", "Wikipedia:Decane" ; oboInOwl:hasExactSynonym "DECANE", "decane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "CH3-[CH2]8-CH3", "Dekan", "n-Dekan", "n-decane" ; oboInOwl:id "CHEBI:41808" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "decane" ; rdfs:subClassOf obo:CHEBI_18310 . obo:CHEBI_41865 obo:IAO_0000115 "An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane." ; chebi:charge "0" ; chebi:formula "C10H18O4" ; chebi:inchi "InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)" ; chebi:inchikey "CXMXRPHRNRROMY-UHFFFAOYSA-N" ; chebi:mass "202.24752" ; chebi:monoisotopicmass "202.12051" ; chebi:smiles "OC(=O)CCCCCCCCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:41860", "CHEBI:9071" ; oboInOwl:hasDbXref "Beilstein:1210591", "CAS:111-20-6", "DrugBank:DB07645", "Gmelin:102423", "HMDB:HMDB0000792", "KEGG:C08277", "KNApSAcK:C00001202", "LIPID_MAPS_instance:LMFA01170006", "MetaCyc:CPD-3623", "PDBeChem:DEC", "PMID:22770225", "PMID:9439441", "Reaxys:1210591", "Wikipedia:Sebacic_acid" ; oboInOwl:hasExactSynonym "SEBACIC ACID", "Sebacic acid", "decanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,10-decanedioic acid", "1,8-dicarboxyoctane", "Decanedioic acid", "Sebacinsaeure" ; oboInOwl:id "CHEBI:41865" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sebacic acid" ; rdfs:subClassOf obo:CHEBI_189840, obo:CHEBI_28383, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_41808 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132954 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_76283 ] . obo:CHEBI_4194 obo:IAO_0000115 "A hexose that has D-configuration at position 5." ; chebi:charge "0" ; chebi:formula "C6H12O6" ; chebi:mass "180.156" ; chebi:monoisotopicmass "180.06339" ; oboInOwl:hasDbXref "KEGG:C00738" ; oboInOwl:hasExactSynonym "D-Hexose", "D-hexopyranose", "D-hexose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-hexoses" ; oboInOwl:id "CHEBI:4194" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-hexose" ; rdfs:subClassOf obo:CHEBI_18133 . obo:CHEBI_41941 obo:IAO_0000115 "A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine." ; chebi:charge "0" ; chebi:formula "C8H8O4" ; chebi:inchi "InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)" ; chebi:inchikey "CFFZDZCDUFSOFZ-UHFFFAOYSA-N" ; chebi:mass "168.14672" ; chebi:monoisotopicmass "168.04226" ; chebi:smiles "OC(=O)Cc1ccc(O)c(O)c1" ; oboInOwl:hasAlternativeId "CHEBI:1386", "CHEBI:41936" ; oboInOwl:hasDbXref "Beilstein:2211017", "CAS:102-32-9", "DrugBank:DB01702", "Gmelin:874810", "HMDB:HMDB0001336", "KEGG:C01161", "PDBeChem:DHY", "PMID:11251641", "PMID:11681538", "PMID:11868042", "PMID:15212971", "PMID:15862791", "PMID:18706927", "PMID:19191673", "PMID:22770225", "PMID:4420192", "Reaxys:2211017", "Wikipedia:DOPAC" ; oboInOwl:hasExactSynonym "(3,4-dihydroxyphenyl)acetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-(3,4-DIHYDROXYPHENYL)ACETIC ACID", "3,4-Dihydroxyphenyl acetic acid", "3,4-Dihydroxyphenylacetic acid", "3,4-dihydroxyphenylacetic acid", "dopacetic acid", "homoprotocatechuic acid" ; oboInOwl:id "CHEBI:41941" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(3,4-dihydroxyphenyl)acetic acid" ; rdfs:subClassOf obo:CHEBI_33566, obo:CHEBI_61409, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30745 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17612 ] . obo:CHEBI_42090 obo:IAO_0000115 "The L-enantiomer of threitol." ; chebi:charge "0" ; chebi:formula "C4H10O4" ; chebi:inchi "InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4-/m0/s1" ; chebi:inchikey "UNXHWFMMPAWVPI-IMJSIDKUSA-N" ; chebi:mass "122.11980" ; chebi:monoisotopicmass "122.05791" ; chebi:smiles "OC[C@H](O)[C@@H](O)CO" ; oboInOwl:hasDbXref "Beilstein:1719754", "Beilstein:4652748", "Beilstein:5725953", "DrugBank:DB03278", "Gmelin:1971390", "PDBeChem:DTL", "PMID:15639248", "PMID:16671745", "PMID:16901854", "PMID:7925706", "Reaxys:1719754" ; oboInOwl:hasExactSynonym "(2S,3S)-butane-1,2,3,4-tetrol", "L-threitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-TREITOL", "L-threo-tetritol" ; oboInOwl:id "CHEBI:42090" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-threitol" ; rdfs:subClassOf obo:CHEBI_26981, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_48300 ] . obo:CHEBI_42111 obo:IAO_0000115 "An optically active form of lactic acid having (R)-configuration." ; chebi:charge "0" ; chebi:formula "C3H6O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1" ; chebi:inchikey "JVTAAEKCZFNVCJ-UWTATZPHSA-N" ; chebi:mass "90.07794" ; chebi:monoisotopicmass "90.03169" ; chebi:smiles "C[C@@H](O)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:341", "CHEBI:42105", "CHEBI:43701" ; oboInOwl:hasDbXref "Beilstein:1720252", "CAS:10326-41-7", "DrugBank:DB03066", "DrugBank:DB04398", "Gmelin:362718", "HMDB:HMDB0001311", "KEGG:C00256", "KNApSAcK:C00019549", "PDBeChem:LAC", "PMID:21842515", "PMID:22127808", "PMID:22277286", "PMID:22344644", "Reaxys:1720252", "Wikipedia:Lactic_acid" ; oboInOwl:hasExactSynonym "(2R)-2-hydroxypropanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(-)-lactic acid", "(R)-(-)-lactic acid", "D-2-Hydroxypropanoic acid", "D-2-Hydroxypropionic acid", "D-Lactic acid", "D-Milchsaeure", "D-lactic acid", "LACTIC ACID" ; oboInOwl:id "CHEBI:42111" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-lactic acid" ; rdfs:subClassOf obo:CHEBI_78320, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16004 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_422 ] . obo:CHEBI_422 obo:IAO_0000115 "An optically active form of lactic acid having (S)-configuration." ; chebi:charge "0" ; chebi:formula "C3H6O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1" ; chebi:inchikey "JVTAAEKCZFNVCJ-REOHCLBHSA-N" ; chebi:mass "90.07794" ; chebi:monoisotopicmass "90.03169" ; chebi:smiles "C[C@H](O)C(O)=O" ; oboInOwl:hasDbXref "Beilstein:1720251", "CAS:79-33-4", "Gmelin:362717", "HMDB:HMDB0000190", "KEGG:C00186", "KNApSAcK:C00001191", "PMID:21996028", "PMID:22336740", "PMID:22367529", "PMID:22424924", "PMID:22443585", "PMID:22461545", "PMID:22534372", "PMID:22538963", "PMID:22578598", "Reaxys:1720251", "Wikipedia:Lactic_Acid" ; oboInOwl:hasExactSynonym "(2S)-2-hydroxypropanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+)-lactic acid", "(S)-(+)-lactic acid", "(S)-2-hydroxypropanoic acid", "(S)-2-hydroxypropionic acid", "L-(+)-alpha-hydroxypropionic acid", "L-(+)-lactic acid", "L-Lactic acid", "L-Milchsaeure" ; oboInOwl:id "CHEBI:422" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-lactic acid" ; rdfs:subClassOf obo:CHEBI_17375, obo:CHEBI_78320, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16651 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_42111 ] . obo:CHEBI_42485 chebi:charge "0" ; chebi:formula "CHO" ; chebi:mass "29.01804" ; chebi:monoisotopicmass "29.00274" ; chebi:smiles "[H]C(*)=O" ; oboInOwl:hasAlternativeId "CHEBI:24089", "CHEBI:42480" ; oboInOwl:hasDbXref "PDBeChem:FOR" ; oboInOwl:hasExactSynonym "FORMYL GROUP", "aldehyde group", "carbaldehyde", "formyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-CH(O)", "-CHO", "Fo", "H-CO-", "methanoyl" ; oboInOwl:id "CHEBI:42485" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "formyl group" ; rdfs:subClassOf obo:CHEBI_27207, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_30751 ] . obo:CHEBI_43176 chebi:charge "0" ; chebi:formula "HO" ; chebi:mass "17.00734" ; chebi:monoisotopicmass "17.00274" ; chebi:smiles "*O[H]" ; oboInOwl:hasAlternativeId "CHEBI:24706", "CHEBI:43171" ; oboInOwl:hasDbXref "PDBeChem:OH" ; oboInOwl:hasExactSynonym "HYDROXY GROUP", "hydroxy", "hydroxy group" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-OH", "hydroxyl", "hydroxyl group" ; oboInOwl:id "CHEBI:43176" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy group" ; rdfs:subClassOf obo:CHEBI_33246 . obo:CHEBI_43254 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:43254" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one" ; rdfs:subClassOf obo:CHEBI_38337, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17568 ] . obo:CHEBI_43474 obo:IAO_0000115 "A phosphate ion that is the conjugate base of dihydrogenphosphate." ; chebi:charge "-2" ; chebi:formula "HO4P" ; chebi:inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2" ; chebi:inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-L" ; chebi:mass "95.97930" ; chebi:monoisotopicmass "95.96234" ; chebi:smiles "OP([O-])([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:29139", "CHEBI:43470" ; oboInOwl:hasDbXref "Gmelin:1998", "MolBase:1628", "PDBeChem:PI", "PDBeChem:PO4" ; oboInOwl:hasExactSynonym "hydrogen(tetraoxidophosphate)(2-)", "hydrogenphosphate", "hydrogentetraoxophosphate(2-)", "hydrogentetraoxophosphate(V)", "hydroxidotrioxidophosphate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HPO4(2-)", "HYDROGENPHOSPHATE ION", "INORGANIC PHOSPHATE GROUP", "[P(OH)O3](2-)", "[PO3(OH)](2-)", "hydrogen phosphate", "phosphate" ; oboInOwl:id "CHEBI:43474" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogenphosphate" ; rdfs:subClassOf obo:CHEBI_35780, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_23357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18367 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_39745 ] . obo:CHEBI_43799 obo:IAO_0000115 "A primary aliphatic amine that is butane substituted by an amino group at position 1." ; chebi:charge "0" ; chebi:formula "C4H11N" ; chebi:inchi "InChI=1S/C4H11N/c1-2-3-4-5/h2-5H2,1H3" ; chebi:inchikey "HQABUPZFAYXKJW-UHFFFAOYSA-N" ; chebi:mass "73.13680" ; chebi:monoisotopicmass "73.08915" ; chebi:smiles "CCCCN" ; oboInOwl:hasDbXref "Beilstein:605269", "CAS:109-73-9", "DrugBank:DB03659", "Gmelin:1784", "MetaCyc:BUTYLAMINE", "PDBeChem:LYT", "PMID:16387436", "PMID:23470444", "PMID:23734590", "Reaxys:605269", "Wikipedia:N-Butylamine" ; oboInOwl:hasExactSynonym "butan-1-amine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-Aminobutan", "1-aminobutane", "1-butanamine", "1-butylamine", "BUTYLAMINE", "butanamine", "butylamine", "mono-n-butylamine", "monobutylamine", "n-Butylamin", "n-C4H9NH2", "n-butylamine" ; oboInOwl:id "CHEBI:43799" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "butan-1-amine" ; rdfs:subClassOf obo:CHEBI_17062 . obo:CHEBI_4439 obo:IAO_0000115 "A mucopolysaccharide consisting of repeating beta-(1->4)-linked L-iduronyl-(alpha1->3)-N-acetyl-D-galactosamine units." ; chebi:charge "0" ; chebi:formula "(C14H21NO11)n" ; oboInOwl:hasDbXref "KEGG:C01490" ; oboInOwl:hasExactSynonym "Dermatan" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Dermatan L-iduronate" ; oboInOwl:id "CHEBI:4439" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dermatan" ; rdfs:subClassOf obo:CHEBI_37395, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_60059 ] . obo:CHEBI_45212 obo:IAO_0000115 "A divalent inorganic anion obtained by removal of both protons from diphosphoric acid." ; chebi:charge "-2" ; chebi:formula "H2O7P2" ; chebi:inchi "InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-2" ; chebi:inchikey "XPPKVPWEQAFLFU-UHFFFAOYSA-L" ; chebi:mass "175.95920" ; chebi:monoisotopicmass "175.92867" ; chebi:smiles "OP([O-])(=O)OP(O)([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:33018", "CHEBI:45208" ; oboInOwl:hasDbXref "DrugBank:DB02212", "Gmelin:185085", "PDBeChem:POP" ; oboInOwl:hasExactSynonym "dihydrogen diphosphate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2P2O7(2-)", "PYROPHOSPHATE 2-" ; oboInOwl:id "CHEBI:45212" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diphosphate(2-)" ; rdfs:subClassOf obo:CHEBI_35782, obo:CHEBI_79388, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_33019 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33017 ] . obo:CHEBI_45557 chebi:charge "0" ; chebi:formula "C4H9" ; chebi:mass "57.11426" ; chebi:monoisotopicmass "57.07043" ; chebi:smiles "CC(*)CC" ; oboInOwl:hasAlternativeId "CHEBI:30352", "CHEBI:45554" ; oboInOwl:hasDbXref "PDBeChem:NBU" ; oboInOwl:hasExactSynonym "1-methylpropyl", "SEC-BUTYL GROUP", "butan-2-ido", "butan-2-yl", "sec-butyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-CH(CH3)-CH2-CH3", "CH3-CH2-CH(CH3)-", "but-2-yl", "isoleucine side-chain", "s-butyl" ; oboInOwl:id "CHEBI:45557" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sec-butyl group" ; rdfs:subClassOf obo:CHEBI_22323, obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_37808 ] . obo:CHEBI_45630 obo:IAO_0000115 "An oxopentanoic acid with the oxo group in the 4-position." ; chebi:charge "0" ; chebi:formula "C5H8O3" ; chebi:inchi "InChI=1S/C5H8O3/c1-4(6)2-3-5(7)8/h2-3H2,1H3,(H,7,8)" ; chebi:inchikey "JOOXCMJARBKPKM-UHFFFAOYSA-N" ; chebi:mass "116.11522" ; chebi:monoisotopicmass "116.04734" ; chebi:smiles "CC(=O)CCC(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:39149", "CHEBI:45628" ; oboInOwl:hasDbXref "Beilstein:506796", "CAS:123-76-2", "DrugBank:DB02239", "Gmelin:164703", "HMDB:HMDB0000720", "LIPID_MAPS_instance:LMFA01060006", "PDBeChem:SHF", "PMID:13215009", "PMID:16662002", "PMID:19246769", "PMID:23627123", "Reaxys:506796", "Wikipedia:Levulinic_acid" ; oboInOwl:hasExactSynonym "4-oxopentanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-acetylpropionic acid", "3-ketobutane-1-carboxylic acid", "4-ketovaleric acid", "4-oxovaleric acid", "LAEVULINIC ACID", "LEVA", "Laevulinsaeure", "Levulinsaeure", "beta-acetylpropionic acid", "gamma-ketovaleric acid", "levulic acid", "levulinic acid" ; oboInOwl:id "CHEBI:45630" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-oxopentanoic acid" ; rdfs:subClassOf obo:CHEBI_25799, obo:CHEBI_39418, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_39150 ] . obo:CHEBI_45696 chebi:charge "-1" ; chebi:formula "HO4S" ; chebi:inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1" ; chebi:inchikey "QAOWNCQODCNURD-UHFFFAOYSA-M" ; chebi:mass "97.07154" ; chebi:monoisotopicmass "96.96010" ; chebi:smiles "[H]OS([O-])(=O)=O" ; oboInOwl:hasAlternativeId "CHEBI:29199", "CHEBI:45693" ; oboInOwl:hasDbXref "Gmelin:2121" ; oboInOwl:hasExactSynonym "hydrogen(tetraoxidosulfate)(1-)", "hydrogensulfate", "hydrogensulfate(1-)", "hydrogentetraoxosulfate(1-)", "hydrogentetraoxosulfate(VI)", "hydroxidotrioxidosulfate(1-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HSO4(-)", "HYDROGEN SULFATE", "[SO3(OH)](-)" ; oboInOwl:id "CHEBI:45696" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogensulfate" ; rdfs:subClassOf obo:CHEBI_33482, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16189 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26836 ] . obo:CHEBI_46629 chebi:charge "0" ; chebi:formula "O" ; chebi:mass "15.99940" ; chebi:monoisotopicmass "15.99491" ; chebi:smiles "O=*" ; oboInOwl:hasAlternativeId "CHEBI:29353", "CHEBI:44607" ; oboInOwl:hasDbXref "PDBeChem:O" ; oboInOwl:hasExactSynonym "OXO GROUP", "oxo" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "=O" ; oboInOwl:id "CHEBI:46629" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo group" ; rdfs:subClassOf obo:CHEBI_33246 . obo:CHEBI_46662 obo:IAO_0000115 "In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals')." ; oboInOwl:hasDbXref "Wikipedia:Mineral" ; oboInOwl:hasExactSynonym "mineral" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Minerale", "minerales", "minerals", "mineraux" ; oboInOwl:id "CHEBI:46662" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mineral" ; rdfs:subClassOf obo:CHEBI_59999 . obo:CHEBI_46701 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrrolidinemonocarboxylic acids" ; oboInOwl:id "CHEBI:46701" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidinemonocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_25384, obo:CHEBI_46767 . obo:CHEBI_46723 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "phosphate minerals" ; oboInOwl:id "CHEBI:46723" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphate mineral" ; rdfs:subClassOf obo:CHEBI_46662 . obo:CHEBI_46761 obo:IAO_0000115 "Any molecule that contains two amino-acid residues connected by peptide linkages." ; oboInOwl:hasAlternativeId "CHEBI:23835", "CHEBI:4634" ; oboInOwl:hasDbXref "KEGG:C00107" ; oboInOwl:hasExactSynonym "Dipeptide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Dipeptid", "dipeptides" ; oboInOwl:id "CHEBI:46761" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dipeptide" ; rdfs:subClassOf obo:CHEBI_25676, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_90799 ] . obo:CHEBI_46767 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrrolidinecarboxylic acids" ; oboInOwl:id "CHEBI:46767" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidinecarboxylic acid" ; rdfs:subClassOf obo:CHEBI_38260 . obo:CHEBI_46773 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxypyrrolidines" ; oboInOwl:id "CHEBI:46773" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxypyrrolidine" ; rdfs:subClassOf obo:CHEBI_38260 . obo:CHEBI_46775 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-alkylpyrrolidines" ; oboInOwl:id "CHEBI:46775" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-alkylpyrrolidine" ; rdfs:subClassOf obo:CHEBI_38260, obo:CHEBI_50996 . obo:CHEBI_46787 obo:IAO_0000115 "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." ; oboInOwl:hasDbXref "Wikipedia:Solvent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Loesungsmittel", "solvant", "solvents" ; oboInOwl:id "CHEBI:46787" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "solvent" ; rdfs:subClassOf obo:CHEBI_33232, obo:CHEBI_51086 . obo:CHEBI_46818 obo:IAO_0000115 "An organic anion obtained by removal of at least one proton from any uric acid." ; oboInOwl:hasExactSynonym "urate anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:46818" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "urate anion" ; rdfs:subClassOf obo:CHEBI_25696, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27226 ] . obo:CHEBI_46819 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:46819" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "urate salt" ; rdfs:subClassOf obo:CHEBI_24868, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_46818 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_27226 ] . obo:CHEBI_46842 obo:IAO_0000115 "An alpha-amino-acid cation that is the conjugate acid of sarcosine, arising from protonation of the amino group." ; chebi:charge "+1" ; chebi:formula "C3H8NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)/p+1" ; chebi:inchikey "FSYKKLYZXJSNPZ-UHFFFAOYSA-O" ; chebi:mass "90.10116" ; chebi:monoisotopicmass "90.05495" ; chebi:smiles "[H][N+]([H])(C)CC(O)=O" ; oboInOwl:hasDbXref "Gmelin:323778" ; oboInOwl:hasExactSynonym "carboxy-N-methylmethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:46842" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sarcosinium" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_15611 ] . obo:CHEBI_46883 chebi:charge "0" ; chebi:formula "CHO2" ; chebi:mass "45.01744" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "*C(=O)O" ; oboInOwl:hasAlternativeId "CHEBI:23025", "CHEBI:41420" ; oboInOwl:hasDbXref "PDBeChem:FMT" ; oboInOwl:hasExactSynonym "CARBOXY GROUP", "carboxy" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-C(O)OH", "-CO2H", "-COOH", "carboxyl group" ; oboInOwl:id "CHEBI:46883" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboxy group" ; rdfs:subClassOf obo:CHEBI_33249 . obo:CHEBI_46904 obo:IAO_0000115 "A dicarboxylic acid monoanion that is the conjugate base of oxalic acid." ; chebi:charge "-1" ; chebi:formula "C2HO4" ; chebi:inchi "InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-1" ; chebi:inchikey "MUBZPKHOEPUJKR-UHFFFAOYSA-M" ; chebi:mass "89.02694" ; chebi:monoisotopicmass "88.98803" ; chebi:smiles "OC(=O)C([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3601755", "Gmelin:49515" ; oboInOwl:hasExactSynonym "carboxyformate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Hox", "hydrogen ethanedioate", "hydrogen oxalate" ; oboInOwl:id "CHEBI:46904" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxalate(1-)" ; rdfs:subClassOf obo:CHEBI_132952, obo:CHEBI_35695, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_30623 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16995 ] . obo:CHEBI_46912 chebi:charge "+1" ; chebi:formula "C5H13N2O2" ; chebi:inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+1" ; chebi:inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-O" ; chebi:mass "133.16900" ; chebi:monoisotopicmass "133.09715" ; chebi:smiles "[NH3+]CCCC([NH3+])C([O-])=O" ; oboInOwl:hasExactSynonym "2,5-diammoniopentanoate", "ornithinium", "ornithinium(1+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ornithine monocation" ; oboInOwl:id "CHEBI:46912" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ornithinium(1+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18257 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_46913 ] . obo:CHEBI_46913 chebi:charge "+2" ; chebi:formula "C5H14N2O2" ; chebi:inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+2" ; chebi:inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-P" ; chebi:mass "134.17694" ; chebi:monoisotopicmass "134.10443" ; chebi:smiles "[NH3+]CCCC([NH3+])C(O)=O" ; oboInOwl:hasExactSynonym "1-carboxybutane-1,4-diaminium", "ornithinediium", "ornithinium(2+)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ornithine dication" ; oboInOwl:id "CHEBI:46913" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ornithinium(2+)" ; rdfs:subClassOf obo:CHEBI_33719, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_46912 ] . obo:CHEBI_46915 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of sarcosine, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H6NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)/p-1" ; chebi:inchikey "FSYKKLYZXJSNPZ-UHFFFAOYSA-M" ; chebi:mass "88.08528" ; chebi:monoisotopicmass "88.04040" ; chebi:smiles "CNCC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:3536300", "Gmelin:81987", "Reaxys:3536300" ; oboInOwl:hasExactSynonym "(methylamino)acetate", "sarcosinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:46915" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sarcosinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15611 ] . obo:CHEBI_47042 oboInOwl:hasExactSynonym "hydroxycalciol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxycalciols", "hydroxycholecalciferol", "hydroxycholecalciferols" ; oboInOwl:id "CHEBI:47042" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxycalciol" ; rdfs:subClassOf obo:CHEBI_36853, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_28940 ] . obo:CHEBI_47773 obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to very low density lipoproteins (VLDL)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "VLDL cholesterol", "VLDL-C", "pre-beta-lipoprotein cholesterol" ; oboInOwl:id "CHEBI:47773" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "very-low-density lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_50404 . obo:CHEBI_47774 obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "LDL cholesterol", "LDL-C", "beta-lipoprotein cholesterol" ; oboInOwl:id "CHEBI:47774" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "low-density lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_50404 . obo:CHEBI_47775 obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HDL cholesterol", "HDL-C", "alpha-lipoprotein cholesterol" ; oboInOwl:id "CHEBI:47775" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "high-density lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_50404 . obo:CHEBI_47778 obo:IAO_0000115 "Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids." ; oboInOwl:hasAlternativeId "CHEBI:13730", "CHEBI:22230" ; oboInOwl:hasExactSynonym "glyceride", "glycerides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acylglycerols", "glycerides" ; oboInOwl:id "CHEBI:47778" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glyceride" ; rdfs:subClassOf obo:CHEBI_33308, obo:CHEBI_35741 . obo:CHEBI_47788 obo:IAO_0000115 "Any oxo steroid where an oxo substituent is located at position 3." ; chebi:charge "0" ; chebi:formula "C19H29OR" ; chebi:mass "273.434" ; chebi:monoisotopicmass "273.22184" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)=O)C" ; oboInOwl:hasAlternativeId "CHEBI:13607", "CHEBI:1653", "CHEBI:20182", "CHEBI:71186" ; oboInOwl:hasDbXref "KEGG:C01876", "MetaCyc:3-Oxosteroids", "PMID:9811880" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-Oxosteroid", "3-oxo steroids", "3-oxosteroids", "a 3-oxosteroid" ; oboInOwl:id "CHEBI:47788" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-oxo steroid" ; rdfs:subClassOf obo:CHEBI_35789, obo:CHEBI_3992 . obo:CHEBI_47857 oboInOwl:hasAlternativeId "CHEBI:27220", "CHEBI:36947" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "urea derivatives" ; oboInOwl:id "CHEBI:47857" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ureas" ; rdfs:subClassOf obo:CHEBI_33256, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16199 ] . obo:CHEBI_47867 obo:IAO_0000115 "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Indikator" ; oboInOwl:id "CHEBI:47867" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "indicator" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_47868 obo:IAO_0000115 "A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "photosensitising agent" ; oboInOwl:id "CHEBI:47868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "photosensitizing agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_47880 oboInOwl:hasAlternativeId "CHEBI:26762" ; oboInOwl:hasDbXref "KEGG:C15506" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "steroid esters" ; oboInOwl:id "CHEBI:47880" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid ester" ; rdfs:subClassOf obo:CHEBI_35341, obo:CHEBI_35701 . obo:CHEBI_47882 oboInOwl:hasExactSynonym "macrocyclic polypyrroles" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic polypyrroles", "polypyrrole macrocycles" ; oboInOwl:id "CHEBI:47882" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic polypyrrole" ; rdfs:subClassOf obo:CHEBI_38077 . obo:CHEBI_47891 obo:IAO_0000115 "Any steroid substituted by at least one carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "steroid acids" ; oboInOwl:id "CHEBI:47891" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid acid" ; rdfs:subClassOf obo:CHEBI_35341, obo:CHEBI_64709, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_50160 ] . obo:CHEBI_47909 obo:IAO_0000115 "A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position." ; chebi:charge "0" ; chebi:formula "C19H27OR" ; chebi:mass "271.418" ; chebi:monoisotopicmass "271.20619" ; chebi:smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC=4C2(CCC(C4)=O)C" ; oboInOwl:hasAlternativeId "CHEBI:13604", "CHEBI:1626", "CHEBI:20157" ; oboInOwl:hasDbXref "KEGG:C00619", "MetaCyc:3-Oxo-Delta-4-Steroids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-Oxo-delta4-steroid", "3-oxo Delta(4)-steroid", "3-oxo Delta(4)-steroids", "3-oxo-Delta(4) steroids", "a 3-oxo-Delta(4)-steroid" ; oboInOwl:id "CHEBI:47909" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-oxo-Delta(4) steroid" ; rdfs:subClassOf obo:CHEBI_47788, obo:CHEBI_51689, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_136849 ] . obo:CHEBI_48154 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Schwefeloxide", "oxides of sulfur", "sulfur oxides" ; oboInOwl:id "CHEBI:48154" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur oxide" ; rdfs:subClassOf obo:CHEBI_24836, obo:CHEBI_26835 . obo:CHEBI_48299 obo:IAO_0000115 "A tetritol that is butane substituted by hydroxy groups at positions 1, 2, 3 and 4." ; chebi:charge "0" ; chebi:formula "C4H10O4" ; chebi:inchi "InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2" ; chebi:inchikey "UNXHWFMMPAWVPI-UHFFFAOYSA-N" ; chebi:mass "122.11980" ; chebi:monoisotopicmass "122.05791" ; chebi:smiles "OCC(O)C(O)CO" ; oboInOwl:hasDbXref "Beilstein:1735878", "CAS:149-32-6", "CAS:7541-59-5", "KEGG:C00503", "KEGG:D08915", "KNApSAcK:C00001161", "Reaxys:1735878" ; oboInOwl:hasExactSynonym "butane-1,2,3,4-tetrol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,2,3,4-tetrahydroxybutane", "Erythrite", "Erythrol", "Phycite", "Phycitol" ; oboInOwl:id "CHEBI:48299" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "butane-1,2,3,4-tetrol" ; rdfs:subClassOf obo:CHEBI_33729 . obo:CHEBI_48300 obo:IAO_0000115 "The D-enantiomer of threitol." ; chebi:charge "0" ; chebi:formula "C4H10O4" ; chebi:inchi "InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4-/m1/s1" ; chebi:inchikey "UNXHWFMMPAWVPI-QWWZWVQMSA-N" ; chebi:mass "122.11980" ; chebi:monoisotopicmass "122.05791" ; chebi:smiles "OC[C@@H](O)[C@H](O)CO" ; oboInOwl:hasDbXref "Beilstein:1719752", "Beilstein:5725952", "CAS:2418-52-2", "CAS:7493-90-5", "DrugBank:DB03278", "Gmelin:1782960", "HMDB:HMDB0004136", "KEGG:C16884", "MetaCyc:CPD-12825", "PDBeChem:DTL", "PMID:1596913", "PMID:16748290", "PMID:16901854", "PMID:17577890", "PMID:17979222", "PMID:18863753", "PMID:22735334", "PMID:24643482", "PMID:25108762", "PMID:5855592", "PMID:6368527", "PMID:908147", "Reaxys:1719752", "Wikipedia:Threitol" ; oboInOwl:hasExactSynonym "(2R,3R)-butane-1,2,3,4-tetrol", "D-threitol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-threo-tetritol" ; oboInOwl:id "CHEBI:48300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-threitol" ; rdfs:subClassOf obo:CHEBI_26981, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_42090 ] . obo:CHEBI_48343 obo:IAO_0000115 "Compounds of structure RSSR'." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "disulfides" ; oboInOwl:id "CHEBI:48343" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "disulfide" ; rdfs:subClassOf obo:CHEBI_26835 . obo:CHEBI_48354 obo:IAO_0000115 "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." ; oboInOwl:hasExactSynonym "polar solvent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polar solvents" ; oboInOwl:id "CHEBI:48354" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polar solvent" ; rdfs:subClassOf obo:CHEBI_46787 . obo:CHEBI_48355 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:48355" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "non-polar solvent" ; rdfs:subClassOf obo:CHEBI_46787 . obo:CHEBI_48356 obo:IAO_0000115 "A polar solvent that is capable of acting as a hydron (proton) donor." ; oboInOwl:hasExactSynonym "protogenic solvent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:48356" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "protic solvent" ; rdfs:subClassOf obo:CHEBI_39141, obo:CHEBI_48354 . obo:CHEBI_48359 obo:IAO_0000115 "Solvent that is capable of acting as a hydron (proton) acceptor." ; oboInOwl:hasExactSynonym "protophilic solvent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "HBA solvent", "hydrogen bond acceptor solvent" ; oboInOwl:id "CHEBI:48359" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "protophilic solvent" ; rdfs:subClassOf obo:CHEBI_39142, obo:CHEBI_48354 . obo:CHEBI_48360 obo:IAO_0000115 "Self-ionizing solvent possessing both characteristics of Bronsted acids and bases." ; oboInOwl:hasExactSynonym "amphiprotic solvent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:48360" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amphiprotic solvent" ; rdfs:subClassOf obo:CHEBI_48356, obo:CHEBI_48359 . obo:CHEBI_48376 chebi:charge "0" ; chebi:formula "CH4N2O" ; chebi:inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" ; chebi:inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" ; chebi:mass "60.05534" ; chebi:monoisotopicmass "60.03236" ; chebi:smiles "NC(O)=N" ; oboInOwl:hasDbXref "Beilstein:773698", "CAS:4744-36-9" ; oboInOwl:hasExactSynonym "carbamimidic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2N-C(=NH)-OH", "H2N-C(OH)=NH", "HO-C(=NH)-NH2", "Isoharnstoff", "carbamimic acid", "carbonamidimidic acid", "isourea", "pseudourea" ; oboInOwl:id "CHEBI:48376" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbamimidic acid" ; rdfs:subClassOf obo:CHEBI_48379, obo:CHEBI_64708, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16199 ] . obo:CHEBI_48377 obo:IAO_0000115 "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." ; oboInOwl:hasExactSynonym "imidic acid", "imidic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "imidic acids", "imino acids" ; oboInOwl:id "CHEBI:48377" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidic acid" ; rdfs:subClassOf obo:CHEBI_33241, obo:CHEBI_51143 . obo:CHEBI_48378 oboInOwl:hasExactSynonym "carboximidic acid", "carboximidic acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carboximidic acids" ; oboInOwl:id "CHEBI:48378" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carboximidic acid" ; rdfs:subClassOf obo:CHEBI_35352, obo:CHEBI_48377 . obo:CHEBI_48379 obo:IAO_0000115 "A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives." ; oboInOwl:hasExactSynonym "isoureas" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "isoureas" ; oboInOwl:id "CHEBI:48379" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isourea" ; rdfs:subClassOf obo:CHEBI_48378 . obo:CHEBI_48539 obo:IAO_0000115 "Any drug that acts on an alpha-adrenergic receptor." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-adrenergic drugs" ; oboInOwl:id "CHEBI:48539" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-adrenergic drug" ; rdfs:subClassOf obo:CHEBI_37962 . obo:CHEBI_48540 obo:IAO_0000115 "Any of the drugs that act on beta-adrenergic receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-adrenergic drugs" ; oboInOwl:id "CHEBI:48540" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-adrenergic drug" ; rdfs:subClassOf obo:CHEBI_37962 . obo:CHEBI_48560 obo:IAO_0000115 "A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dopamine agent", "dopamine agents", "dopamine drug", "dopamine drugs", "dopaminergic agents" ; oboInOwl:id "CHEBI:48560" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dopaminergic agent" ; rdfs:subClassOf obo:CHEBI_35942 . obo:CHEBI_48578 obo:IAO_0000115 "A role played by a substance that can react readily with, and thereby eliminate, radicals." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "free radical scavengers", "free-radical scavenger" ; oboInOwl:id "CHEBI:48578" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "radical scavenger" ; rdfs:subClassOf obo:CHEBI_22586 . obo:CHEBI_48705 obo:IAO_0000115 "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." ; oboInOwl:hasExactSynonym "agonist" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "agonista", "agoniste", "agonists" ; oboInOwl:id "CHEBI:48705" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "agonist" ; rdfs:subClassOf obo:CHEBI_52210 . obo:CHEBI_48706 obo:IAO_0000115 "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." ; oboInOwl:hasExactSynonym "antagonist" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antagonista", "antagoniste", "antagonists" ; oboInOwl:id "CHEBI:48706" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antagonist" ; rdfs:subClassOf obo:CHEBI_52210 . obo:CHEBI_48854 chebi:charge "0" ; chebi:formula "H2O3S" ; chebi:inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)" ; chebi:inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-N" ; chebi:mass "82.08008" ; chebi:monoisotopicmass "81.97247" ; chebi:smiles "OS(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:26837", "CHEBI:9344" ; oboInOwl:hasDbXref "CAS:7782-99-2", "Gmelin:1458", "KEGG:C00094", "KNApSAcK:C00019662", "PDBeChem:SO3", "UM-BBD_compID:c0348" ; oboInOwl:hasExactSynonym "Sulfurous acid", "dihydrogen trioxosulfate", "dihydroxidooxidosulfur", "sulfurous acid", "trioxosulfuric acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2SO3", "S(O)(OH)2", "Sulfite", "[SO(OH)2]", "acide sulfureux", "acido sulfuroso", "schweflige Saeure", "sulphurous acid" ; oboInOwl:id "CHEBI:48854" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfurous acid" ; rdfs:subClassOf obo:CHEBI_33402, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17137 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_29214 ] . obo:CHEBI_48873 obo:IAO_0000115 "Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Anticholinergika", "Anticholinergikum", "acetylcholine antagonists", "acetylcholine receptor antagonist", "agent anticholinergique", "agente anticolinergico", "agentes anticolinergicos", "anticholinergic agents", "anticholinergics", "anticholinergiques", "anticolinergicos", "cholinergic-blocking agents" ; oboInOwl:id "CHEBI:48873" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholinergic antagonist" ; rdfs:subClassOf obo:CHEBI_38323 . obo:CHEBI_48927 obo:IAO_0000115 "Any L-alpha-amino acid carrying an N-acyl substituent." ; chebi:charge "0" ; chebi:formula "C3H3NO3R2" ; chebi:mass "101.061" ; chebi:monoisotopicmass "101.01129" ; oboInOwl:hasAlternativeId "CHEBI:13240", "CHEBI:7232" ; oboInOwl:hasDbXref "KEGG:C02850" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-Acyl-L-amino acid" ; oboInOwl:id "CHEBI:48927" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-L-alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_21644, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_15705 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59874 ] . obo:CHEBI_48937 chebi:charge "0" ; chebi:formula "C20H42" ; chebi:inchi "InChI=1S/C20H42/c1-7-18(4)12-9-14-20(6)16-10-15-19(5)13-8-11-17(2)3/h17-20H,7-16H2,1-6H3" ; chebi:inchikey "GGYKPYDKXLHNTI-UHFFFAOYSA-N" ; chebi:mass "282.54748" ; chebi:monoisotopicmass "282.32865" ; chebi:smiles "CCC(C)CCCC(C)CCCC(C)CCCC(C)C" ; oboInOwl:hasDbXref "Beilstein:1744639", "CAS:638-36-8" ; oboInOwl:hasExactSynonym "2,6,10,14-tetramethylhexadecane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Phytan" ; oboInOwl:id "CHEBI:48937" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phytane" ; rdfs:subClassOf obo:CHEBI_35190 . obo:CHEBI_48944 obo:IAO_0000115 "A branched, short-chain, saturated fatty acid anion; the conjugate base of isobutyric acid, formed by deprotonation of the carboxylic acid group." ; chebi:charge "-1" ; chebi:formula "C4H7O2" ; chebi:inchi "InChI=1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)/p-1" ; chebi:inchikey "KQNPFQTWMSNSAP-UHFFFAOYSA-M" ; chebi:mass "87.09718" ; chebi:monoisotopicmass "87.04515" ; chebi:smiles "CC(C)C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:11627", "CHEBI:25334" ; oboInOwl:hasDbXref "Beilstein:3903644", "CAS:5711-69-3", "Gmelin:324364", "MetaCyc:ISOBUTYRATE", "Reaxys:3903644", "UM-BBD_compID:c0383" ; oboInOwl:hasExactSynonym "2-methylpropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-methylpropanoate", "2-methylpropanoic acid, ion(1-)", "2-methylpropionate", "Isobutyrat", "i-butyrate", "iPrCO2 anion", "isobutanoate", "isobutyric acid anion", "methylpropanoate" ; oboInOwl:id "CHEBI:48944" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "isobutyrate" ; rdfs:subClassOf obo:CHEBI_58956, obo:CHEBI_78115, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17272 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16135 ] . obo:CHEBI_48999 obo:IAO_0000115 "A monocarboxylic acid anion that is obtained by removal of a proton from the carboxylic acid group of 4-hydroxyphenylacetic acid." ; chebi:charge "-1" ; chebi:formula "C8H7O3" ; chebi:inchi "InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1" ; chebi:inchikey "XQXPVVBIMDBYFF-UHFFFAOYSA-M" ; chebi:mass "151.13938" ; chebi:monoisotopicmass "151.04007" ; chebi:smiles "Oc1ccc(CC([O-])=O)cc1" ; oboInOwl:hasDbXref "MetaCyc:4-HYDROXYPHENYLACETATE", "Reaxys:3905591" ; oboInOwl:hasExactSynonym "(4-hydroxyphenyl)acetate", "4-hydroxyphenylacetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(p-hydroxyphenyl)acetate", "2-(4-hydroxyphenyl)ethanoate", "4-hydroxybenzeneacetate" ; oboInOwl:id "CHEBI:48999" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyphenylacetate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76946 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30089 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18101 ] . obo:CHEBI_49095 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:49095" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "beta-amino-acid anion" ; rdfs:subClassOf obo:CHEBI_37022 . obo:CHEBI_49096 obo:IAO_0000115 "A beta-amino acid anion that is the conjugate base of 3-aminoisobutyric acid, arising from deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C4H8NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/p-1" ; chebi:inchikey "QCHPKSFMDHPSNR-UHFFFAOYSA-M" ; chebi:mass "102.11186" ; chebi:monoisotopicmass "102.05605" ; chebi:smiles "CC(CN)C([O-])=O" ; oboInOwl:hasDbXref "PMID:17190852" ; oboInOwl:hasExactSynonym "3-amino-2-methylpropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-aminoisobutyrate" ; oboInOwl:id "CHEBI:49096" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-aminoisobutyrate" ; rdfs:subClassOf obo:CHEBI_49095, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_142590 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27389 ] . obo:CHEBI_49167 obo:IAO_0000115 "A drug used to treat asthma." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-asthmatic agent", "anti-asthmatic agents", "anti-asthmatic drugs" ; oboInOwl:id "CHEBI:49167" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anti-asthmatic drug" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_65023 . obo:CHEBI_49302 oboInOwl:hasAlternativeId "CHEBI:19626", "CHEBI:35967" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxy acid", "2-hydroxy monocarboxylic acids" ; oboInOwl:id "CHEBI:49302" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxy monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35868 . obo:CHEBI_49323 obo:IAO_0000115 "A chemical substance that prevents or reduces the probability of conception." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "contraceptive agent", "contraceptive drugs" ; oboInOwl:id "CHEBI:49323" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "contraceptive drug" ; rdfs:subClassOf obo:CHEBI_50689 . obo:CHEBI_49637 chebi:charge "0" ; chebi:formula "H" ; chebi:inchi "InChI=1S/H" ; chebi:inchikey "YZCKVEUIGOORGS-UHFFFAOYSA-N" ; chebi:mass "1.00794" ; chebi:monoisotopicmass "1.00783" ; chebi:smiles "[H]" ; oboInOwl:hasAlternativeId "CHEBI:24634", "CHEBI:49636" ; oboInOwl:hasDbXref "WebElements:H" ; oboInOwl:hasExactSynonym "hydrogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1H", "H", "Wasserstoff", "hidrogeno", "hydrogen", "hydrogene" ; oboInOwl:id "CHEBI:49637" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydrogen atom" ; rdfs:subClassOf obo:CHEBI_24835, obo:CHEBI_25585, obo:CHEBI_33559, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_33937 ] . obo:CHEBI_50047 obo:IAO_0000115 "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic amino compounds" ; oboInOwl:id "CHEBI:50047" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic amino compound" ; rdfs:subClassOf obo:CHEBI_35352, obo:CHEBI_50860, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_39142 ], [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_16134 ] . obo:CHEBI_50103 obo:IAO_0000115 "An agent that binds to and activates excitatory amino acid receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "excitatory amino acid agonists", "excitatory amino acid receptor agonist", "excitatory amino acid receptor agonists" ; oboInOwl:id "CHEBI:50103" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "excitatory amino acid agonist" ; rdfs:subClassOf obo:CHEBI_35942 . obo:CHEBI_50112 obo:IAO_0000115 "Any hormone that is responsible for controlling sexual characteristics and reproductive function." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Geschlechtshormon", "Geschlechtshormone", "Sexualhormon", "Sexualhormone", "hormone sexuelle", "hormones sexuelles", "sex hormones" ; oboInOwl:id "CHEBI:50112" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sex hormone" ; rdfs:subClassOf obo:CHEBI_24621 . obo:CHEBI_50113 obo:IAO_0000115 "A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors." ; oboInOwl:hasExactSynonym "Androgen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Androgene", "androgene", "androgenes", "androgeno", "androgenos", "androgens" ; oboInOwl:id "CHEBI:50113" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "androgen" ; rdfs:subClassOf obo:CHEBI_50112 . obo:CHEBI_50114 obo:IAO_0000115 "A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens." ; oboInOwl:hasDbXref "Wikipedia:Estrogen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Estrogene", "Oestrogen", "Oestrogene", "estrogene", "estrogenes", "estrogenes Hormon", "estrogeno", "estrogenos", "estrogens", "oestrogen", "oestrogene", "oestrogenes", "oestrogens" ; oboInOwl:id "CHEBI:50114" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "estrogen" ; rdfs:subClassOf obo:CHEBI_50112 . obo:CHEBI_50160 obo:IAO_0000115 "Any anion formed by loss of a proton from a steroid acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "steroid acid anions" ; oboInOwl:id "CHEBI:50160" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "steroid acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_47891 ] . obo:CHEBI_50177 obo:IAO_0000115 "A drug used to treat or prevent skin disorders or for the routine care of skin." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dermatologic agent", "dermatologic drugs", "dermatological agent" ; oboInOwl:id "CHEBI:50177" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dermatologic drug" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50188 obo:IAO_0000115 "A substance that can be converted into a vitamin by animal tissues." ; oboInOwl:hasDbXref "Wikipedia:Provitamin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "provitamins" ; oboInOwl:id "CHEBI:50188" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "provitamin" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_50248 obo:IAO_0000115 "Drug that acts on blood and blood-forming organs and those that affect the hemostatic system." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hematologic agents" ; oboInOwl:id "CHEBI:50248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hematologic agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50249 obo:IAO_0000115 "An agent that prevents blood clotting." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anticoagulante", "anticoagulants" ; oboInOwl:id "CHEBI:50249" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anticoagulant" ; rdfs:subClassOf obo:CHEBI_50248 . obo:CHEBI_50263 obo:IAO_0000115 "Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group." ; chebi:formula "C3H4O5(CH2)n" ; oboInOwl:hasAlternativeId "CHEBI:1154", "CHEBI:19636" ; oboInOwl:hasDbXref "KEGG:C03668" ; oboInOwl:hasExactSynonym "2-Hydroxydicarboxylic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-hydroxydicarboxylic acids" ; oboInOwl:id "CHEBI:50263" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxydicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35692, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_167114 ] . obo:CHEBI_50266 obo:IAO_0000115 "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." ; oboInOwl:hasDbXref "PMID:23993918", "PMID:23998799", "PMID:24329110", "PMID:24628402", "PMID:24709544", "PMID:25144792", "PMID:25157234", "PMID:25269430", "PMID:25391982", "PMID:25591121", "PMID:25620096", "PMID:25795057", "PMID:26028253", "PMID:26184144", "PMID:28070577", "PMID:28215138", "PMID:28219047", "PMID:28259775", "PMID:28319647", "PMID:28329729", "PMID:28334528", "Wikipedia:Prodrug" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Prodrugs" ; oboInOwl:id "CHEBI:50266" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prodrug" ; rdfs:subClassOf obo:CHEBI_136859, obo:CHEBI_23888 . obo:CHEBI_50267 obo:IAO_0000115 "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chemoprotectant", "chemoprotectants", "chemoprotective agent", "chemoprotective agents", "protective agents" ; oboInOwl:id "CHEBI:50267" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "protective agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50312 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:50312" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "onium compound" ; rdfs:subClassOf obo:CHEBI_37577 . obo:CHEBI_50313 obo:IAO_0000115 "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." ; oboInOwl:hasExactSynonym "onium cations" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "onium cations", "onium ion", "onium ions" ; oboInOwl:id "CHEBI:50313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "onium cation" ; rdfs:subClassOf obo:CHEBI_50312 . obo:CHEBI_50315 chebi:charge "+1" ; chebi:formula "ClH2" ; chebi:inchi "InChI=1S/ClH2/h1H2/q+1" ; chebi:inchikey "IGJWHVUMEJASKV-UHFFFAOYSA-N" ; chebi:mass "37.46858" ; chebi:monoisotopicmass "36.98395" ; chebi:smiles "[H][Cl+][H]" ; oboInOwl:hasDbXref "Gmelin:331" ; oboInOwl:hasExactSynonym "chloranium", "chloronium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H2Cl(+)", "[ClH2](+)" ; oboInOwl:id "CHEBI:50315" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chloronium" ; rdfs:subClassOf obo:CHEBI_50313, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17883 ] . obo:CHEBI_50325 obo:IAO_0000115 "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "canonical amino-acid side-chain", "canonical amino-acid side-chains", "proteinogenic amino-acid side-chain", "proteinogenic amino-acid side-chain groups", "proteinogenic amino-acid side-chains" ; oboInOwl:id "CHEBI:50325" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proteinogenic amino-acid side-chain group" ; rdfs:subClassOf obo:CHEBI_33249 . obo:CHEBI_50326 chebi:charge "0" ; chebi:formula "CH3S" ; chebi:mass "47.10052" ; chebi:monoisotopicmass "46.99555" ; chebi:smiles "SC*" ; oboInOwl:hasExactSynonym "sulfanylmethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "-CH2-SH", "HS-CH2-", "cysteine side-chain" ; oboInOwl:id "CHEBI:50326" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfanylmethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50329 chebi:charge "0" ; chebi:formula "C3H5O2" ; chebi:mass "73.07060" ; chebi:monoisotopicmass "73.02895" ; chebi:smiles "C(CC(=O)O)*" ; oboInOwl:hasExactSynonym "2-carboxyethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutamic acid side-chain" ; oboInOwl:id "CHEBI:50329" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-carboxyethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50330 chebi:charge "0" ; chebi:formula "C2H4NO" ; chebi:mass "58.05930" ; chebi:monoisotopicmass "58.02929" ; chebi:smiles "C(=O)(C*)N" ; oboInOwl:hasExactSynonym "2-amino-2-oxoethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "asparagine side-chain" ; oboInOwl:id "CHEBI:50330" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-amino-2-oxoethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50331 chebi:charge "0" ; chebi:formula "C3H6NO" ; chebi:mass "72.08588" ; chebi:monoisotopicmass "72.04494" ; chebi:smiles "C(CC(=O)N)*" ; oboInOwl:hasExactSynonym "3-amino-3-oxopropyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glutamine side-chain" ; oboInOwl:id "CHEBI:50331" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-amino-3-oxopropyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50336 chebi:charge "0" ; chebi:formula "C7H7O" ; chebi:mass "107.12988" ; chebi:monoisotopicmass "107.04969" ; chebi:smiles "C1=C(C*)C=CC(=C1)O" ; oboInOwl:hasExactSynonym "4-hydroxybenzyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tyrosine side-chain" ; oboInOwl:id "CHEBI:50336" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxybenzyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50337 chebi:charge "0" ; chebi:formula "C9H8N" ; chebi:mass "130.16656" ; chebi:monoisotopicmass "130.06567" ; chebi:smiles "N1C=C(C=2C=CC=CC12)C*" ; oboInOwl:hasExactSynonym "1H-indol-3-ylmethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tryptophan side-chain" ; oboInOwl:id "CHEBI:50337" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1H-indol-3-ylmethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50338 chebi:charge "0" ; chebi:formula "C4H5N2" ; chebi:mass "81.09598" ; chebi:monoisotopicmass "81.04527" ; chebi:smiles "*CC=1N=CNC1" ; oboInOwl:hasExactSynonym "1H-imidazol-4-ylmethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "histidine side-chain" ; oboInOwl:id "CHEBI:50338" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1H-imidazol-4-ylmethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50339 chebi:charge "0" ; chebi:formula "C4H10N" ; chebi:mass "72.12894" ; chebi:monoisotopicmass "72.08132" ; chebi:smiles "NCCCC*" ; oboInOwl:hasExactSynonym "4-aminobutyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "lysine side-chain" ; oboInOwl:id "CHEBI:50339" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-aminobutyl group" ; rdfs:subClassOf obo:CHEBI_50325, [ a owl:Restriction ; owl:onProperty chebi1:is_substituent_group_from ; owl:someValuesFrom obo:CHEBI_43799 ] . obo:CHEBI_50340 chebi:charge "0" ; chebi:formula "C4H10N3" ; chebi:mass "100.14242" ; chebi:monoisotopicmass "100.08747" ; chebi:smiles "NC(=N)NCCC*" ; oboInOwl:hasExactSynonym "3-carbamimidamidopropyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-(carbamimidoylamino)propyl", "3-guanidinopropyl", "arginine side-chain" ; oboInOwl:id "CHEBI:50340" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-carbamimidamidopropyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50341 chebi:charge "0" ; chebi:formula "C2H5O" ; chebi:mass "45.06050" ; chebi:monoisotopicmass "45.03404" ; chebi:smiles "OC(C)*" ; oboInOwl:hasExactSynonym "1-hydroxyethyl" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "threonine side-chain" ; oboInOwl:id "CHEBI:50341" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1-hydroxyethyl group" ; rdfs:subClassOf obo:CHEBI_50325 . obo:CHEBI_50401 obo:IAO_0000115 "Any steroid based on a cholestane skeleton and its derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cholestanoids" ; oboInOwl:id "CHEBI:50401" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cholestanoid" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35516 ] . obo:CHEBI_50402 obo:IAO_0000115 "Any steroid based on an androstane skeleton and its derivatives." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "androstanoids" ; oboInOwl:id "CHEBI:50402" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "androstanoid" ; rdfs:subClassOf obo:CHEBI_35341, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_35509 ] . obo:CHEBI_50404 obo:IAO_0000115 "Cholesterol esters and free cholesterol which are contained in or bound to lipoproteins." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:50404" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lipoprotein cholesterol" ; rdfs:subClassOf obo:CHEBI_50401 . obo:CHEBI_50503 obo:IAO_0000115 "An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aperient", "aperients", "laxante", "laxatives", "purgative", "purgatives" ; oboInOwl:id "CHEBI:50503" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "laxative" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50505 obo:IAO_0000115 "Substance that sweeten food, beverages, medications, etc." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sweetener", "sweeteners" ; oboInOwl:id "CHEBI:50505" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sweetening agent" ; rdfs:subClassOf obo:CHEBI_35617 . obo:CHEBI_50513 obo:IAO_0000115 "Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mydriatics" ; oboInOwl:id "CHEBI:50513" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mydriatic agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50514 obo:IAO_0000115 "Drug used to cause constriction of the blood vessels." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:50514" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vasoconstrictor agent" ; rdfs:subClassOf obo:CHEBI_35554 . obo:CHEBI_50584 obo:IAO_0000115 "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." ; oboInOwl:hasAlternativeId "CHEBI:22937", "CHEBI:50581" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alkyl alcohols", "hydroxyalkane", "hydroxyalkanes" ; oboInOwl:id "CHEBI:50584" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alkyl alcohol" ; rdfs:subClassOf obo:CHEBI_2571 . obo:CHEBI_50646 obo:IAO_0000115 "An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis." ; oboInOwl:hasAlternativeId "CHEBI:72497" ; oboInOwl:hasDbXref "Wikipedia:Osteoporosis" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-osteopenia agent", "anti-osteopenia agents", "anti-osteopenia drug", "anti-osteopenia drugs", "anti-osteoporosis agent", "anti-osteoporosis agents", "anti-osteoporosis drug", "anti-osteoporosis drugs", "anti-osteoporotic", "anti-osteoporotic agent", "anti-osteoporotic agents", "anti-osteoporotic drug", "anti-osteoporotic drugs", "anti-osteoporotics", "antiosteoporotic", "antiosteoporotics", "bone density conservation agents", "bone density conservation drug", "bone density conservation drugs" ; oboInOwl:id "CHEBI:50646" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bone density conservation agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50689 obo:IAO_0000115 "A substance used either in the prevention or facilitation of pregnancy." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "reproductive control agent", "reproductive control drugs" ; oboInOwl:id "CHEBI:50689" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "reproductive control drug" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50699 obo:IAO_0000115 "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." ; oboInOwl:hasAlternativeId "CHEBI:25679", "CHEBI:35319", "CHEBI:7758" ; oboInOwl:hasDbXref "KEGG:C00930" ; oboInOwl:hasExactSynonym "Oligosaccharide", "oligosaccharides" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "O-glycosylglycoside", "O-glycosylglycosides", "oligosacarido", "oligosacaridos" ; oboInOwl:id "CHEBI:50699" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oligosaccharide" ; rdfs:subClassOf obo:CHEBI_16646, obo:CHEBI_167559 . obo:CHEBI_50733 obo:IAO_0000115 "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Dietary Supplement", "Food Supplementation", "Nutritional supplement" ; oboInOwl:id "CHEBI:50733" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nutraceutical" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_507393 obo:IAO_0000115 "The zwitterion formed from taurine by transfer of a proton from the sulfonyl to the amino group. It is the major species existing at physiological pH." ; chebi:charge "0" ; chebi:formula "C2H7NO3S" ; chebi:inchi "InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)" ; chebi:inchikey "XOAAWQZATWQOTB-UHFFFAOYSA-N" ; chebi:mass "125.14700" ; chebi:monoisotopicmass "125.01466" ; chebi:smiles "[NH3+]CCS([O-])(=O)=O" ; oboInOwl:hasDbXref "PMID:17765547" ; oboInOwl:hasExactSynonym "2-azaniumylethane-1-sulfonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammonioethanesulfonate", "taurine" ; oboInOwl:id "CHEBI:507393" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "taurine zwitterion" ; rdfs:subClassOf obo:CHEBI_27369, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15891 ] . obo:CHEBI_50745 obo:IAO_0000115 "A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gestagen", "gestagens", "progestagen", "progestagens", "progestogens" ; oboInOwl:id "CHEBI:50745" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "progestogen" ; rdfs:subClassOf obo:CHEBI_50112 . obo:CHEBI_50748 obo:IAO_0000115 "A drug used to treat psoriasis." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antipsoriatic agent", "antipsoriatic drug" ; oboInOwl:id "CHEBI:50748" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antipsoriatic" ; rdfs:subClassOf obo:CHEBI_50177 . obo:CHEBI_50846 obo:IAO_0000115 "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." ; oboInOwl:hasDbXref "Wikipedia:Immunotherapy" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Biomodulator", "Immune factor", "Immunologic factor", "Immunological factor", "immunomodulators" ; oboInOwl:id "CHEBI:50846" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "immunomodulator" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_24432 . obo:CHEBI_50857 obo:IAO_0000115 "A drug used to treat allergic reactions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-allergic agents", "anti-allergic drug", "anti-allergic drugs" ; oboInOwl:id "CHEBI:50857" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anti-allergic agent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_50858 obo:IAO_0000115 "A natural or synthetic analogue of the hormones secreted by the adrenal gland." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "corticoides", "corticosteroides", "corticosteroids" ; oboInOwl:id "CHEBI:50858" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "corticosteroid" ; rdfs:subClassOf obo:CHEBI_35341 . obo:CHEBI_50860 obo:IAO_0000115 "Any molecular entity that contains carbon." ; oboInOwl:hasAlternativeId "CHEBI:25700", "CHEBI:33244" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic compounds", "organic entity", "organic molecular entities" ; oboInOwl:id "CHEBI:50860" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic molecular entity" ; rdfs:subClassOf obo:CHEBI_33582, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_27594 ] . obo:CHEBI_50903 obo:IAO_0000115 "A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "agente carcinogeno", "cancerigene", "cancerogene", "carcinogen", "carcinogene", "carcinogenic agents", "carcinogeno", "carcinogens" ; oboInOwl:id "CHEBI:50903" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carcinogenic agent" ; rdfs:subClassOf obo:CHEBI_52209 . obo:CHEBI_50904 obo:IAO_0000115 "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." ; oboInOwl:hasDbXref "Wikipedia:Allergen" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alergeno", "allergene", "allergenic agent" ; oboInOwl:id "CHEBI:50904" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "allergen" ; rdfs:subClassOf obo:CHEBI_52209 . obo:CHEBI_50906 obo:IAO_0000115 "A role is particular behaviour which a material entity may exhibit." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:50906" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "role" ; rdfs:subClassOf obo:PATO_0000001 . obo:CHEBI_50910 obo:IAO_0000115 "A poison that interferes with the functions of the nervous system." ; oboInOwl:hasAlternativeId "CHEBI:50911" ; oboInOwl:hasDbXref "Wikipedia:Neurotoxin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "agente neurotoxico", "nerve poison", "nerve poisons", "neurotoxic agent", "neurotoxic agents", "neurotoxicant", "neurotoxins" ; oboInOwl:id "CHEBI:50910" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neurotoxin" ; rdfs:subClassOf obo:CHEBI_52209, obo:CHEBI_64909 . obo:CHEBI_50967 obo:IAO_0000115 "Systems consisting of two or more molecular entities held together by non-covalent interactions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "non-covalently-bound molecular entities" ; oboInOwl:id "CHEBI:50967" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "non-covalently-bound molecular entity" ; rdfs:subClassOf obo:CHEBI_36357 . obo:CHEBI_50994 obo:IAO_0000115 "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "primary amino compounds" ; oboInOwl:id "CHEBI:50994" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary amino compound" ; rdfs:subClassOf obo:CHEBI_50047, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_65296 ] . obo:CHEBI_50996 obo:IAO_0000115 "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tertiary amino compounds" ; oboInOwl:id "CHEBI:50996" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tertiary amino compound" ; rdfs:subClassOf obo:CHEBI_50047, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_137982 ] . obo:CHEBI_51060 obo:IAO_0000115 "A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:51060" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hormone agonist" ; rdfs:subClassOf obo:CHEBI_48705, obo:CHEBI_51061 . obo:CHEBI_51061 obo:IAO_0000115 "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hormone receptor modulators" ; oboInOwl:id "CHEBI:51061" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hormone receptor modulator" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_90710 . obo:CHEBI_51086 obo:IAO_0000115 "A role played by the molecular entity or part thereof within a chemical context." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:51086" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chemical role" ; rdfs:subClassOf obo:CHEBI_50906 . obo:CHEBI_51143 oboInOwl:hasAlternativeId "CHEBI:25556", "CHEBI:7594" ; oboInOwl:hasDbXref "KEGG:C06061" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Nitrogenous compounds", "nitrogen compounds", "nitrogen molecular entities" ; oboInOwl:id "CHEBI:51143" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nitrogen molecular entity" ; rdfs:subClassOf obo:CHEBI_33302, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_25555 ] . obo:CHEBI_51151 obo:IAO_0000115 "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dipolar compounds" ; oboInOwl:id "CHEBI:51151" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dipolar compound" ; rdfs:subClassOf obo:CHEBI_72695 . obo:CHEBI_51422 obo:IAO_0000115 "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organodiyl groups" ; oboInOwl:id "CHEBI:51422" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organodiyl group" ; rdfs:subClassOf obo:CHEBI_51446 . obo:CHEBI_51446 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:51446" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "organic divalent group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_51447 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:51447" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "organic univalent group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_51569 obo:IAO_0000115 "A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid." ; oboInOwl:hasAlternativeId "CHEBI:21653", "CHEBI:22226" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acyl amino acid", "N-acyl amino acids", "N-acyl-amino-acid", "N-acyl-amino-acids", "N-acylamino acid", "N-acylamino acids", "acyl-amino-acid", "acyl-amino-acids", "acylamino acids" ; oboInOwl:id "CHEBI:51569" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-amino acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_37622, obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_33709 ] . obo:CHEBI_51683 obo:IAO_0000115 "Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methoxybenzene" ; oboInOwl:id "CHEBI:51683" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methoxybenzenes" ; rdfs:subClassOf obo:CHEBI_22712, obo:CHEBI_35618 . obo:CHEBI_51689 obo:IAO_0000115 "An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position." ; chebi:charge "0" ; chebi:formula "C3OR4" ; chebi:mass "52.03150" ; chebi:monoisotopicmass "51.99491" ; chebi:smiles "[*]\\C([*])=C(\\[*])C([*])=O" ; oboInOwl:hasDbXref "Wikipedia:Enone" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "enones" ; oboInOwl:id "CHEBI:51689" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "enone" ; rdfs:subClassOf obo:CHEBI_51721, obo:CHEBI_78840 . obo:CHEBI_51721 obo:IAO_0000115 "A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha,beta-unsaturated ketones" ; oboInOwl:id "CHEBI:51721" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha,beta-unsaturated ketone" ; rdfs:subClassOf obo:CHEBI_17087 . obo:CHEBI_51958 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic polycyclic compounds" ; oboInOwl:id "CHEBI:51958" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic polycyclic compound" ; rdfs:subClassOf obo:CHEBI_33635, obo:CHEBI_33832 . obo:CHEBI_52090 obo:IAO_0000115 "An organic anion that is the conjugate base of methanol." ; chebi:charge "-1" ; chebi:formula "CH3O" ; chebi:inchi "InChI=1S/CH3O/c1-2/h1H3/q-1" ; chebi:inchikey "NBTOZLQBSIZIKS-UHFFFAOYSA-N" ; chebi:mass "31.03390" ; chebi:monoisotopicmass "31.01894" ; chebi:smiles "C[O-]" ; oboInOwl:hasDbXref "Reaxys:1839368" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methoxide ion" ; oboInOwl:id "CHEBI:52090" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methoxide" ; rdfs:subClassOf obo:CHEBI_25696, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17790 ] . obo:CHEBI_52206 obo:IAO_0000115 "A biological role played by the molecular entity or part thereof within a biochemical context." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:52206" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biochemical role" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52208 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:52208" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "biophysical role" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52209 obo:IAO_0000115 "A role played by the molecular entity or part thereof which causes the development of a pathological process." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "etiopathogenetic agent", "etiopathogenetic role" ; oboInOwl:id "CHEBI:52209" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aetiopathogenetic role" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52210 obo:IAO_0000115 "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:52210" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pharmacological role" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52211 oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:52211" ; oboInOwl:inSubset chebi5:_STAR ; a owl:Class ; rdfs:label "physiological role" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52214 obo:IAO_0000115 "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." ; oboInOwl:hasDbXref "Wikipedia:Ligand" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ligands" ; oboInOwl:id "CHEBI:52214" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ligand" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_52215 obo:IAO_0000115 "A chemical role played by the molecular entity or part thereof in a photochemical process." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "photochemical roles" ; oboInOwl:id "CHEBI:52215" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "photochemical role" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_52217 obo:IAO_0000115 "Any substance introduced into a living organism with therapeutic or diagnostic purpose." ; oboInOwl:hasAlternativeId "CHEBI:33293", "CHEBI:33294" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "farmaco", "medicament", "pharmaceuticals" ; oboInOwl:id "CHEBI:52217" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pharmaceutical" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_52254 obo:IAO_0000115 "A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl." ; oboInOwl:hasDbXref "HMDB:HMDB0033610" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxyapatite" ; oboInOwl:id "CHEBI:52254" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "apatite" ; rdfs:subClassOf obo:CHEBI_46723 . obo:CHEBI_52255 obo:IAO_0000115 "A phosphate mineral with the formula Ca5(PO4)3(OH)." ; chebi:charge "0" ; chebi:formula "Ca5HO13P3" ; chebi:mass "502.312" ; chebi:monoisotopicmass "501.67595" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:52255" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxylapatite" ; rdfs:subClassOf obo:CHEBI_52254 . obo:CHEBI_52290 obo:IAO_0000115 "A chemical substance that encourages a cell to commence cell division, triggering mitosis." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mitogens" ; oboInOwl:id "CHEBI:52290" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mitogen" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_52395 obo:IAO_0000115 "A compound with the general formula R2C=O (R=/=H) where one or more of the R groups contains an oxy (-O-) group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxyketones" ; oboInOwl:id "CHEBI:52395" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxyketone" ; rdfs:subClassOf obo:CHEBI_17087 . obo:CHEBI_52396 obo:IAO_0000115 "An oxyketone with the general formula R2C(=O) (R=/=H) where one or more of the R groups contains an oxy (-O-) group and the oxy and carbonyl groups are bonded to the same carbon atom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-oxyketones" ; oboInOwl:id "CHEBI:52396" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-oxyketone" ; rdfs:subClassOf obo:CHEBI_52395 . obo:CHEBI_52424 obo:IAO_0000115 "An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*)." ; oboInOwl:hasAlternativeId "CHEBI:76776" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.2.1.* (glycosidase) inhibitors", "EC 3.2.1.* inhibitor", "EC 3.2.1.* inhibitors", "glycosidase (EC 3.2.1.*) inhibitor", "glycosidase (EC 3.2.1.*) inhibitors", "glycosidase inhibitor", "glycosidase inhibitors", "glycoside hydrolase inhibitors" ; oboInOwl:id "CHEBI:52424" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.2.1.* (glycosidase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76761 . obo:CHEBI_52425 obo:IAO_0000115 "An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.2.1.18 (exo-alpha-sialidase) inhibitors", "EC 3.2.1.18 inhibitor", "EC 3.2.1.18 inhibitors", "N-acylneuraminate glycohydrolase inhibitor", "N-acylneuraminate glycohydrolase inhibitors", "acetylneuraminidase inhibitor", "acetylneuraminidase inhibitors", "acetylneuraminyl hydrolase inhibitor", "acetylneuraminyl hydrolase inhibitors", "alpha-neuraminidase inhibitor", "alpha-neuraminidase inhibitors", "exo-alpha-sialidase (EC 3.2.1.18) inhibitor", "exo-alpha-sialidase (EC 3.2.1.18) inhibitors", "exo-alpha-sialidase inhibitor", "exo-alpha-sialidase inhibitors", "neuraminidase inhibitor", "neuraminidase inhibitors", "sialidase inhibitor", "sialidase inhibitors" ; oboInOwl:id "CHEBI:52425" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.2.1.18 (exo-alpha-sialidase) inhibitor" ; rdfs:subClassOf obo:CHEBI_36044, obo:CHEBI_52424 . obo:CHEBI_52845 obo:IAO_0000115 "An organic group that consists of a closed ring. It may be a substituent or a skeleton." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cyclic organic groups" ; oboInOwl:id "CHEBI:52845" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic organic group" ; rdfs:subClassOf obo:CHEBI_33247 . obo:CHEBI_53000 obo:IAO_0000115 "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antigenic determinant", "epitope function", "epitope role" ; oboInOwl:id "CHEBI:53000" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "epitope" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_53291 obo:IAO_0000115 "A halophenol in which the halogen atom is bonded to the carbon atom adjacent to the C-OH group." ; chebi:charge "0" ; chebi:formula "C6H5OX" ; chebi:mass "93.10330" ; chebi:monoisotopicmass "93.03404" ; chebi:smiles "Oc1ccccc1*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-halophenols" ; oboInOwl:id "CHEBI:53291" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-halophenol" ; rdfs:subClassOf obo:CHEBI_38856 . obo:CHEBI_533015 obo:IAO_0000115 "The amino acid zwitterion formed from 3,3',5-triiodo-L-thyronine by tranfer of a proton from the carboxy group to the amino group. It is the major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C15H12I3NO4" ; chebi:inchi "InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1" ; chebi:inchikey "AUYYCJSJGJYCDS-LBPRGKRZSA-N" ; chebi:mass "650.97350" ; chebi:monoisotopicmass "650.79004" ; chebi:smiles "[NH3+][C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:CPD-10813" ; oboInOwl:hasExactSynonym "(2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid", "3,3',5-triiodo-L-thyronine" ; oboInOwl:id "CHEBI:533015" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3,3',5-triiodo-L-thyronine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_18258 ] . obo:CHEBI_53309 obo:IAO_0000115 "A polymer carrying multiple negative charges." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyanion", "polyanions" ; oboInOwl:id "CHEBI:53309" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyanionic macromolecule" ; rdfs:subClassOf obo:CHEBI_33839, obo:CHEBI_53368 . obo:CHEBI_53368 obo:IAO_0000115 "A macromolecule containing ionic groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ionic polymer", "polyionic macromolecule" ; oboInOwl:id "CHEBI:53368" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ionic macromolecule" ; rdfs:subClassOf obo:CHEBI_33839 . obo:CHEBI_5386 oboInOwl:hasDbXref "COMe:PRX000257", "KEGG:C06258" ; oboInOwl:hasExactSynonym "Globin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "globins", "pentacoordinate globin" ; oboInOwl:id "CHEBI:5386" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "globin" ; rdfs:subClassOf obo:CHEBI_35137 . obo:CHEBI_545959 obo:IAO_0000115 "A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite." ; chebi:charge "0" ; chebi:formula "C9H10O4" ; chebi:inchi "InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)" ; chebi:inchikey "QRMZSPFSDQBLIX-UHFFFAOYSA-N" ; chebi:mass "182.17330" ; chebi:monoisotopicmass "182.05791" ; chebi:smiles "COc1cc(CC(O)=O)ccc1O" ; oboInOwl:hasAlternativeId "CHEBI:5758" ; oboInOwl:hasDbXref "CAS:306-08-1", "HMDB:HMDB0000118", "KEGG:C05582", "KNApSAcK:C00029504", "MetaCyc:CPD-7651", "PMID:14688447", "PMID:24007816", "PMID:24416192", "PMID:24423636", "PMID:8353435", "Reaxys:2213447", "Wikipedia:Homovanillic_acid" ; oboInOwl:hasExactSynonym "2-(4-hydroxy-3-methoxyphenyl)acetic acid", "Homovanillic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(4-hydroxy-3-methoxyphenyl)acetic acid", "3-Methoxy-4-hydroxyphenylacetate", "3-Methoxy-4-hydroxyphenylacetic acid", "4-Hydroxy-3-methoxybenzeneacetic acid", "HVA", "Vanillacetic acid" ; oboInOwl:id "CHEBI:545959" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homovanillic acid" ; rdfs:subClassOf obo:CHEBI_134251, obo:CHEBI_25384, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_41941 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_133744 ] . obo:CHEBI_546807 obo:IAO_0000115 "An amino disaccharide consisting of D-galactopyranose at the non-reducing end joined by a (1->3) glycosidic linkage to N-acetyl-D-galactopyranosamine." ; chebi:charge "0" ; chebi:formula "C14H25NO11" ; chebi:inchi "InChI=1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13?,14+/m1/s1" ; chebi:inchikey "HMQPEDMEOBLSQB-UITYFYQISA-N" ; chebi:mass "383.34840" ; chebi:monoisotopicmass "383.14276" ; chebi:smiles "CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O" ; oboInOwl:hasAlternativeId "CHEBI:10382", "CHEBI:22773", "CHEBI:22782", "CHEBI:27716", "CHEBI:62468" ; oboInOwl:hasDbXref "Beilstein:4788642", "CAS:20972-29-6", "GlyGen:G78436BB", "GlyTouCan:G78436BB", "KEGG:C07278", "KEGG:G10607", "PMID:11294842", "PMID:11425800", "PMID:11459848", "PMID:12472179", "PMID:1291050", "PMID:15963963", "PMID:16776550", "PMID:19221437", "PMID:1933953", "PMID:19443021", "PMID:19506091", "PMID:19913595", "PMID:2055602", "PMID:2457603", "PMID:2461959", "PMID:2470785", "PMID:2584393", "PMID:28188832", "PMID:3360006", "PMID:59831", "PMID:7757427", "PMID:9405387", "Reaxys:4788642" ; oboInOwl:hasExactSynonym "beta-D-Galp-(1->3)-D-GalpNAc", "beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galactopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(Gal)1 (GalNAc)1", "2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose", "2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose", "Galbeta1-3GalNAc", "Galbeta1->3GalNAc", "TF epitope", "Thomsen-Friedenreich epitope", "WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1b_1-5]/1-2/a3-b1", "beta-D-Gal-(1->3)-D-GalNAc", "beta-D-Galactopyranosyl-(1->3)-N-acetyl-D-galactosamine", "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine", "beta-D-galactosyl-3-N-acetyl-D-galactosamine" ; oboInOwl:id "CHEBI:546807" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-D-Galp-(1->3)-D-GalpNAc" ; rdfs:subClassOf obo:CHEBI_146500, obo:CHEBI_22480, obo:CHEBI_22484, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ] . obo:CHEBI_5520 obo:IAO_0000115 "A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence." ; chebi:charge "0" ; chebi:formula "C55H75N17O13" ; chebi:inchi "InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1" ; chebi:inchikey "XLXSAKCOAKORKW-AQJXLSMYSA-N" ; chebi:mass "1182.29010" ; chebi:monoisotopicmass "1181.57303" ; chebi:smiles "CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O" ; oboInOwl:hasDbXref "CAS:33515-09-2", "DrugBank:DB00644", "Drug_Central:2958", "KEGG:C07607", "KEGG:D08027", "PMID:21872303", "PMID:22112812", "PMID:22214466", "PMID:22289217", "PMID:22504307", "PMID:22761896", "Reaxys:741807", "Wikipedia:Gonadorelin" ; oboInOwl:hasExactSynonym "5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide", "Gonadorelin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-oxo-PHWSYGLRPGNH2", "Follicle-stimulating hormone-releasing factor", "GnRH-I", "Gonadoliberin I", "Gonadotropin-releasing factor", "Gonadotropin-releasing hormone I", "LH-Releasing factor", "LH-Releasing hormone", "Luteinizing hormone-releasing factor", "gonadorelin", "gonadorelina", "gonadorelinum", "luliberin", "p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2" ; oboInOwl:id "CHEBI:5520" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gonadorelin" ; rdfs:subClassOf obo:CHEBI_25676, obo:CHEBI_25905, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_63533 ] . obo:CHEBI_55370 obo:IAO_0000115 "An imidazolidine containing one or more oxo groups." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "imidazolidinones" ; oboInOwl:id "CHEBI:55370" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "imidazolidinone" ; rdfs:subClassOf obo:CHEBI_38261 . obo:CHEBI_5686 obo:IAO_0000115 "A cyclic compound having as ring members atoms of at least two different elements." ; oboInOwl:hasExactSynonym "Heterocyclic compound" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "compuesto heterociclico", "compuestos heterociclicos", "heterocycle", "heterocyclic compounds" ; oboInOwl:id "CHEBI:5686" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "heterocyclic compound" ; rdfs:subClassOf obo:CHEBI_33595 . obo:CHEBI_57305 obo:IAO_0000115 "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of glycine." ; chebi:charge "0" ; chebi:formula "C2H5NO2" ; chebi:inchi "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)" ; chebi:inchikey "DHMQDGOQFOQNFH-UHFFFAOYSA-N" ; chebi:mass "75.06660" ; chebi:monoisotopicmass "75.03203" ; chebi:smiles "[NH3+]CC([O-])=O" ; oboInOwl:hasDbXref "Gmelin:1807", "MetaCyc:GLY" ; oboInOwl:hasExactSynonym "2-azaniumylacetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycine" ; oboInOwl:id "CHEBI:57305" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15428 ] . obo:CHEBI_57433 obo:IAO_0000115 "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of sarcosine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)" ; chebi:inchikey "FSYKKLYZXJSNPZ-UHFFFAOYSA-N" ; chebi:mass "89.09320" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "C[NH2+]CC([O-])=O" ; oboInOwl:hasDbXref "Gmelin:323777", "MetaCyc:SARCOSINE" ; oboInOwl:hasExactSynonym "(methylazaniumyl)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(methylammonio)acetate", "2-(methylazaniumyl)acetate", "sarcosine" ; oboInOwl:id "CHEBI:57433" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sarcosine zwitterion" ; rdfs:subClassOf obo:CHEBI_66884, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15611 ] . obo:CHEBI_57485 obo:IAO_0000115 "Zwitterionic form of carnosine." ; chebi:charge "0" ; chebi:formula "C9H14N4O3" ; chebi:inchi "InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1" ; chebi:inchikey "CQOVPNPJLQNMDC-ZETCQYMHSA-N" ; chebi:mass "226.23250" ; chebi:monoisotopicmass "226.10659" ; chebi:smiles "[NH3+]CCC(=O)N[C@@H](Cc1c[nH]cn1)C([O-])=O" ; oboInOwl:hasDbXref "Gmelin:397437", "MetaCyc:CARNOSINE" ; oboInOwl:hasExactSynonym "N(alpha)-(beta-alaniniumyl)-L-histidinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-[(3-azaniumylpropanoyl)amino]-3-(1H-imidazol-4-yl)propanoate", "carnosine" ; oboInOwl:id "CHEBI:57485" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carnosine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66874 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15727 ] . obo:CHEBI_57560 obo:IAO_0000115 "A fatty acid anion with a chain length of C13 to C22." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasAlternativeId "CHEBI:13652" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a long-chain carboxylate", "a long-chain fatty acid", "long-chain fatty acid anions" ; oboInOwl:id "CHEBI:57560" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "long-chain fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15904 ] . obo:CHEBI_57606 obo:IAO_0000115 "The conjugate base of 5-oxoproline." ; chebi:charge "-1" ; chebi:formula "C5H6NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1" ; chebi:inchikey "ODHCTXKNWHHXJC-UHFFFAOYSA-M" ; chebi:mass "128.10600" ; chebi:monoisotopicmass "128.03532" ; chebi:smiles "[O-]C(=O)C1CCC(=O)N1" ; oboInOwl:hasDbXref "Beilstein:4135383", "Gmelin:327019" ; oboInOwl:hasExactSynonym "5-oxopyrrolidine-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-oxoprolinate anion", "5-oxoproline", "5-oxopyrrolidine-2-carboxylate", "Pyroglutamate" ; oboInOwl:id "CHEBI:57606" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxoprolinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16010 ] . obo:CHEBI_57630 obo:IAO_0000115 "Zwitterionic form of gamma-amino-beta-hydroxybutyric acid having an anionic carboxy group and a protonated amino group." ; chebi:charge "0" ; chebi:formula "C4H9NO3" ; chebi:inchi "InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)" ; chebi:inchikey "YQGDEPYYFWUPGO-UHFFFAOYSA-N" ; chebi:mass "119.11920" ; chebi:monoisotopicmass "119.05824" ; chebi:smiles "[NH3+]CC(O)CC([O-])=O" ; oboInOwl:hasExactSynonym "4-azaniumyl-3-hydroxybutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-amino-3-hydroxybutanoate", "4-ammonio-3-hydroxybutanoate" ; oboInOwl:id "CHEBI:57630" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-amino-beta-hydroxybutyric acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_11955 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16080 ] . obo:CHEBI_57652 obo:IAO_0000115 "Anionic form of chondroitin D-glucuronate arising from deprotonation of the carboxylic acid groups of the repeating units; major species at pH 7.3." ; chebi:formula "H2O(C14H20NO11)n" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "chondroitin D-glucuronate", "chondroitin D-glucuronate polyanion" ; oboInOwl:id "CHEBI:57652" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chondroitin D-glucuronate anion" ; rdfs:subClassOf obo:CHEBI_61469, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16137 ] . obo:CHEBI_57670 obo:IAO_0000115 "A carboxylic acid anion obtained by deprotonation of the carboxy group of any N-acylglycine." ; chebi:charge "-1" ; chebi:formula "C3H3NO3R" ; chebi:mass "101.06080" ; chebi:monoisotopicmass "101.01129" ; chebi:smiles "[O-]C(=O)CNC([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an N-acylglycine" ; oboInOwl:id "CHEBI:57670" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acylglycinate" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_32508 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16180 ] . obo:CHEBI_57726 obo:IAO_0000115 "A D-alpha-amino acid zwitterion that is D-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C5H9NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-N" ; chebi:mass "115.13050" ; chebi:monoisotopicmass "115.06333" ; chebi:smiles "[O-]C(=O)[C@H]1CCC[NH2+]1" ; oboInOwl:hasDbXref "MetaCyc:D-PROLINE" ; oboInOwl:hasExactSynonym "(2R)-pyrrolidinium-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-proline" ; oboInOwl:id "CHEBI:57726" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-proline zwitterion" ; rdfs:subClassOf obo:CHEBI_59871, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16313 ] . obo:CHEBI_57887 obo:IAO_0000115 "An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "C10H13N2" ; chebi:inchi "InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2/p+1" ; chebi:inchikey "APJYDQYYACXCRM-UHFFFAOYSA-O" ; chebi:mass "161.22310" ; chebi:monoisotopicmass "161.10732" ; chebi:smiles "[NH3+]CCc1c[nH]c2ccccc12" ; oboInOwl:hasDbXref "Gmelin:533978" ; oboInOwl:hasExactSynonym "2-(1H-indol-3-yl)ethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tryptamine", "tryptaminium cation", "tryptaminium(1+)" ; oboInOwl:id "CHEBI:57887" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptaminium" ; rdfs:subClassOf obo:CHEBI_35274, obo:CHEBI_65296, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_16765 ] . obo:CHEBI_57947 obo:IAO_0000115 "Zwitterionic form of creatine arising from transfer of a proton from the carboxy to the guanidino group; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C4H9N3O2" ; chebi:inchi "InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)" ; chebi:inchikey "CVSVTCORWBXHQV-UHFFFAOYSA-N" ; chebi:mass "131.13320" ; chebi:monoisotopicmass "131.06948" ; chebi:smiles "CN(CC([O-])=O)C(N)=[NH2+]" ; oboInOwl:hasDbXref "MetaCyc:CREATINE" ; oboInOwl:hasExactSynonym "{[amino(iminio)methyl](methyl)amino}acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "creatine" ; oboInOwl:id "CHEBI:57947" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "creatine zwitterion" ; rdfs:subClassOf obo:CHEBI_27369, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_66924 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16919 ] . obo:CHEBI_57948 obo:IAO_0000115 "The conjugate base of 5-oxo-D-proline; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C5H6NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1/t3-/m1/s1" ; chebi:inchikey "ODHCTXKNWHHXJC-GSVOUGTGSA-M" ; chebi:mass "128.10600" ; chebi:monoisotopicmass "128.03532" ; chebi:smiles "[O-]C(=O)[C@H]1CCC(=O)N1" ; oboInOwl:hasExactSynonym "(2R)-5-oxopyrrolidine-2-carboxylate", "5-oxo-D-prolinate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-oxo-D-prolinate anion", "5-oxo-D-prolinate(1-)", "5-oxo-D-proline" ; oboInOwl:id "CHEBI:57948" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxo-D-prolinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16924 ] . obo:CHEBI_57966 obo:IAO_0000115 "Zwitterionic form of beta-alanine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)" ; chebi:inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-N" ; chebi:mass "89.09320" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "[NH3+]CCC([O-])=O" ; oboInOwl:hasDbXref "Gmelin:454332" ; oboInOwl:hasExactSynonym "3-azaniumylpropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-ammoniopropanoate", "beta-alanine" ; oboInOwl:id "CHEBI:57966" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-alanine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16958 ] . obo:CHEBI_57977 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." ; chebi:charge "-2" ; chebi:formula "C33H34N4O6" ; chebi:inchi "InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-" ; chebi:inchikey "BPYKTIZUTYGOLE-IFADSCNNSA-L" ; chebi:mass "582.64630" ; chebi:monoisotopicmass "582.24893" ; chebi:smiles "CC1=C(C=C)\\C(NC1=O)=C\\c1[nH]c(Cc2[nH]c(\\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC([O-])=O)c(CCC([O-])=O)c1C" ; oboInOwl:hasDbXref "Beilstein:4083310" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate", "bilirubin IXalpha", "bilirubin dianion" ; oboInOwl:id "CHEBI:57977" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bilirubin(2-)" ; rdfs:subClassOf obo:CHEBI_28965, obo:CHEBI_59252, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16990 ] . obo:CHEBI_58001 obo:IAO_0000115 "The conjugate acid of a primary aliphatic amine." ; chebi:charge "+1" ; chebi:formula "CH5NR" ; chebi:mass "31.05710" ; chebi:monoisotopicmass "31.04220" ; chebi:smiles "[NH3+]C[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an aliphatic amine", "primary aliphatic ammonium cation", "primary aliphatic ammonium cations", "primary aliphatic ammonium ions" ; oboInOwl:id "CHEBI:58001" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary aliphatic ammonium ion" ; rdfs:subClassOf obo:CHEBI_65296, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_17062 ] . obo:CHEBI_58048 obo:IAO_0000115 "Zwitterionic form of L-asparagine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C4H8N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-REOHCLBHSA-N" ; chebi:mass "132.11790" ; chebi:monoisotopicmass "132.05349" ; chebi:smiles "NC(=O)C[C@H]([NH3+])C([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:ASN" ; oboInOwl:hasExactSynonym "(2S)-4-amino-2-azaniumyl-4-oxobutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-ammonio-3-carbamoylpropanoate", "(2S)-2-azaniumyl-3-carbamoylpropanoate", "(2S)-4-amino-2-ammonio-4-oxobutanoate", "L-asparagine" ; oboInOwl:id "CHEBI:58048" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-asparagine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17196 ] . obo:CHEBI_58123 obo:IAO_0000115 "A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (alpha to the carboxy group) and has (S)-stereochemistry; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C2H2O3R" ; chebi:mass "74.03550" ; chebi:monoisotopicmass "74.00039" ; chebi:smiles "O[C@@H]([*])C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:61394", "CHEBI:70794" ; oboInOwl:hasDbXref "PMID:10850983" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-hydroxy monocarboxylate", "(2S)-2-hydroxy monocarboxylates", "(2S)-2-hydroxy monocarboxylic acid anions", "(2S)-2-hydroxycarboxylate", "(2S)-alpha-hydroxy monocarboxylic acid anion", "(2S)-alpha-hydroxy monocarboxylic acid anions", "(S)-2-hydroxyacid anion", "(S)-2-hydroxyacid anions", "a (2S)-2-hydroxycarboxylate" ; oboInOwl:id "CHEBI:58123" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(2S)-2-hydroxy monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17375 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_58314 ] . obo:CHEBI_58126 obo:IAO_0000115 "Conjugate base of porphobilinogen arising from deprotonation of the two carboxy groups and protonation of the amino group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C10H13N2O4" ; chebi:inchi "InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)/p-1" ; chebi:inchikey "QSHWIQZFGQKFMA-UHFFFAOYSA-M" ; chebi:mass "225.22120" ; chebi:monoisotopicmass "225.08808" ; chebi:smiles "[NH3+]Cc1[nH]cc(CCC([O-])=O)c1CC([O-])=O" ; oboInOwl:hasExactSynonym "3-[5-(azaniumylmethyl)-4-(carboxylatomethyl)-1H-pyrrol-3-yl]propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "porphobilinogen", "porphobilinogen anion" ; oboInOwl:id "CHEBI:58126" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "porphobilinogen(1-)" ; rdfs:subClassOf obo:CHEBI_35693, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17381 ] . obo:CHEBI_58163 obo:IAO_0000115 "Dizwitterionic form of homocystine arising from transfer of two protons from the carboxy to the amino groups; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C8H16N2O4S2" ; chebi:inchi "InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)" ; chebi:inchikey "ZTVZLYBCZNMWCF-UHFFFAOYSA-N" ; chebi:mass "268.356" ; chebi:monoisotopicmass "268.05515" ; chebi:smiles "C(C(CCSSCCC(C(=O)[O-])[NH3+])[NH3+])([O-])=O" ; oboInOwl:hasExactSynonym "4,4'-disulfanediylbis(2-azaniumylbutanoate)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4,4'-disulfanediylbis(2-ammoniobutanoate)", "homocystine dizwitterion" ; oboInOwl:id "CHEBI:58163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "homocystine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17485 ] . obo:CHEBI_58314 obo:IAO_0000115 "A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (alpha to the carboxy group) and has (R)-stereochemistry; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C2H2O3R" ; chebi:mass "74.036" ; chebi:monoisotopicmass "74.00039" ; chebi:smiles "O[C@H]([*])C([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:2R-hydroxy-carboxylates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-2-hydroxy monocarboxylic acid anions", "(2R)-2-hydroxycarboxylate", "(2R)-alpha-hydroxy monocarboxylic acid anion", "(2R)-alpha-hydroxy monocarboxylic acid anions", "(R)-2-hydroxyacid anion", "(R)-2-hydroxyacid anions", "a (2R)-2-hydroxycarboxylate" ; oboInOwl:id "CHEBI:58314" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(2R)-2-hydroxy monocarboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_17893 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_58123 ] . obo:CHEBI_58375 obo:IAO_0000115 "An L-alpha-amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of trans-4-hydroxy-L-proline; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1" ; chebi:inchikey "PMMYEEVYMWASQN-DMTCNVIQSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "O[C@H]1C[NH2+][C@@H](C1)C([O-])=O" ; oboInOwl:hasExactSynonym "(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "hydroxyproline zwitterion", "trans-4-hydroxy-L-proline" ; oboInOwl:id "CHEBI:58375" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trans-4-hydroxy-L-proline zwitterion" ; rdfs:subClassOf obo:CHEBI_59869, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_18095 ] . obo:CHEBI_58389 obo:IAO_0000115 "An ammonium ion that is the conjugate acid of trimethylamine, obtained via protonation of the nitrogen; major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "C3H10N" ; chebi:inchi "InChI=1S/C3H9N/c1-4(2)3/h1-3H3/p+1" ; chebi:inchikey "GETQZCLCWQTVFV-UHFFFAOYSA-O" ; chebi:mass "60.11820" ; chebi:monoisotopicmass "60.08078" ; chebi:smiles "C[NH+](C)C" ; oboInOwl:hasDbXref "MetaCyc:TRIMETHYLAMINE", "Reaxys:16709444" ; oboInOwl:hasExactSynonym "N,N-dimethylmethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "trimethylamine", "trimethylammonium cation", "trimethylazanium", "trimethylazanium cation" ; oboInOwl:id "CHEBI:58389" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trimethylammonium" ; rdfs:subClassOf obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18139 ] . obo:CHEBI_58402 obo:IAO_0000115 "Conjugate base of 5-oxo-L-proline." ; chebi:charge "-1" ; chebi:formula "C5H6NO3" ; chebi:inchi "InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1/t3-/m0/s1" ; chebi:inchikey "ODHCTXKNWHHXJC-VKHMYHEASA-M" ; chebi:mass "128.10600" ; chebi:monoisotopicmass "128.03532" ; chebi:smiles "[O-]C(=O)[C@@H]1CCC(=O)N1" ; oboInOwl:hasDbXref "Beilstein:4783230", "Gmelin:675391", "MetaCyc:5-OXOPROLINE" ; oboInOwl:hasExactSynonym "(2S)-5-oxopyrrolidine-2-carboxylate", "5-oxo-L-prolate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5-oxo-L-proline" ; oboInOwl:id "CHEBI:58402" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "5-oxo-L-prolinate" ; rdfs:subClassOf obo:CHEBI_59814, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_32862 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18183 ] . obo:CHEBI_58419 obo:IAO_0000115 "The amino acid zwitterion formed from 4-hydroxy-L-proline. It is the major microspecies present at pH 7.3." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3?,4-/m0/s1" ; chebi:inchikey "PMMYEEVYMWASQN-BKLSDQPFSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "OC1C[NH2+][C@@H](C1)C([O-])=O" ; oboInOwl:hasExactSynonym "(2S)-4-hydroxypyrrolidinium-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-hydroxy-L-proline" ; oboInOwl:id "CHEBI:58419" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxy-L-proline zwitterion" ; rdfs:subClassOf obo:CHEBI_63137, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_18240 ] . obo:CHEBI_58465 obo:IAO_0000115 "The conjugate base of dermatan sulfate, obtained by deprotonation of carboxy and sulfate groups." ; chebi:formula "H2O.(C14H219NO14S)n" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dermatan 4'-sulfate" ; oboInOwl:id "CHEBI:58465" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dermatan sulfate polyanion" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_58958, obo:CHEBI_61469, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18376 ] . obo:CHEBI_58945 obo:IAO_0000115 "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organophosphate oxoanions" ; oboInOwl:id "CHEBI:58945" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organophosphate oxoanion" ; rdfs:subClassOf obo:CHEBI_25696, obo:CHEBI_26079 . obo:CHEBI_58951 obo:IAO_0000115 "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a short-chain fatty acid", "short-chain fatty acid anions" ; oboInOwl:id "CHEBI:58951" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "short-chain fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26666 ] . obo:CHEBI_58953 obo:IAO_0000115 "Any fatty acid anion in which there is no C-C unsaturation." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "saturated fatty acid anions" ; oboInOwl:id "CHEBI:58953" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "saturated fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868 . obo:CHEBI_58954 obo:IAO_0000115 "Any saturated fatty acid anion lacking a carbon side-chain." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "straight-chain saturated fatty acid anions" ; oboInOwl:id "CHEBI:58954" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "straight-chain saturated fatty acid anion" ; rdfs:subClassOf obo:CHEBI_58953, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_39418 ] . obo:CHEBI_58955 obo:IAO_0000115 "Any fatty acid anion with a carbon side-chain or isopropyl termination." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "branched-chain fatty acid anions" ; oboInOwl:id "CHEBI:58955" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35819 ] . obo:CHEBI_58956 obo:IAO_0000115 "Any saturated fatty acid anion with a carbon side-chain or isopropyl termination." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "branched-chain saturated fatty acid anions" ; oboInOwl:id "CHEBI:58956" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain saturated fatty acid anion" ; rdfs:subClassOf obo:CHEBI_58953, obo:CHEBI_58955, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_39417 ] . obo:CHEBI_58958 obo:IAO_0000115 "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." ; chebi:charge "-1" ; chebi:formula "O4SR" ; chebi:mass "96.06300" ; chebi:monoisotopicmass "95.95173" ; chebi:smiles "[O-]S(=O)(=O)O[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organosulfate oxoanions" ; oboInOwl:id "CHEBI:58958" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organosulfate oxoanion" ; rdfs:subClassOf obo:CHEBI_25696, obo:CHEBI_33482, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16189 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_25704 ] . obo:CHEBI_59132 obo:IAO_0000115 "Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antigens" ; oboInOwl:id "CHEBI:59132" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antigen" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_59163 obo:IAO_0000115 "A substance used as an indicator of a biological state." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "biological marker" ; oboInOwl:id "CHEBI:59163" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "biomarker" ; rdfs:subClassOf obo:CHEBI_47867 . obo:CHEBI_59174 obo:IAO_0000115 "Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals." ; oboInOwl:hasDbXref "PMID:17875790", "PMID:17986299", "PMID:19101624", "PMID:291959", "PMID:3782019" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "haptens" ; oboInOwl:id "CHEBI:59174" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hapten" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_59202 obo:IAO_0000115 "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "straight-chain fatty acids" ; oboInOwl:id "CHEBI:59202" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "straight-chain fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59203 ] . obo:CHEBI_59203 obo:IAO_0000115 "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "straight-chain FA anion", "straight-chain FA anions", "straight-chain fatty acid anions" ; oboInOwl:id "CHEBI:59203" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "straight-chain fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_59202 ] . obo:CHEBI_59226 obo:IAO_0000115 "An amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of alpha-N-acetylneuraminyl, beta-D-galactosyl and beta-D-glucose residues linked (2->3) and (1->4)." ; chebi:charge "0" ; chebi:formula "C23H39NO19" ; chebi:inchi "InChI=1S/C23H39NO19/c1-6(28)24-11-7(29)2-23(22(37)38,42-18(11)12(31)8(30)3-25)43-19-13(32)9(4-26)40-21(16(19)35)41-17-10(5-27)39-20(36)15(34)14(17)33/h7-21,25-27,29-36H,2-5H2,1H3,(H,24,28)(H,37,38)/t7-,8+,9+,10+,11+,12+,13-,14+,15+,16+,17+,18+,19-,20+,21-,23-/m0/s1" ; chebi:inchikey "CILYIEBUXJIHCO-UITFWXMXSA-N" ; chebi:mass "633.55110" ; chebi:monoisotopicmass "633.21163" ; chebi:smiles "CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O" ; oboInOwl:hasAlternativeId "CHEBI:85038" ; oboInOwl:hasDbXref "Beilstein:4632263", "GlyGen:G91237TK", "GlyTouCan:G91237TK", "HMDB:HMDB0000825", "PMID:11164910", "PMID:12058986", "PMID:12950597", "PMID:14613940", "PMID:15179041", "PMID:19443021", "PMID:24027187", "PMID:25568069", "PMID:3142362", "PMID:31537530", "PMID:33164488", "PMID:3768140", "PMID:510308", "PMID:599156", "PMID:6672002", "PMID:7507746", "PMID:7706301", "Reaxys:4632263" ; oboInOwl:hasExactSynonym "(6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose", "5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose", "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2->3')-a-Sialyllactose", "(2->3')-alpha-Sialyllactose", "(2S,4S,5R,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid", "3'-(N-Acetyl-a-neuraminosyl)lactose", "3'-(N-Acetyl-alpha-neuraminosyl)lactose", "3'-Monosialyllactose", "3'-N-Acetylneuraminyl-D-lactose", "3'-N-Acetylneuraminyl-delta-lactose", "3'-Sialyl-D-lactose", "3'-Sialyl-delta-lactose", "3'-a-Sialyllactose", "3'-alpha-Sialyllactose", "3'-sialyllactose", "32-N-Acetyl-a-neuraminyllactose", "32-N-Acetyl-alpha-neuraminyllactose", "A2,3-Sialyllactose", "GM3 carbohydrate moiety", "N-Acetylneuraminoyllactose", "Neu5Aca2-3Galb1-4Glcb", "Neu5Acalpha2-3Galbeta1-4Glcbeta", "WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3/a4-b1_b3-c2", "a-Neu5Ac-(2->3)-b-D-Gal-(1->4)-D-Glc", "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose", "alpha-Neu5Ac-(2->3)-beta-D-Gal-(->4)-D-Glc", "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc", "alpha-Neu5Ac-(2->3)-beta-delta-Gal-(1->4)-delta-Glc", "alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp" ; oboInOwl:id "CHEBI:59226" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose" ; rdfs:subClassOf obo:CHEBI_59266, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75768 ] . obo:CHEBI_59238 obo:IAO_0000115 "Any fatty acid containing anywhere in its structure a ring of atoms." ; oboInOwl:hasDbXref "PMID:17113094", "PMID:9300789" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acides gras cycliques", "acidos grasos ciclicos", "cyclic fatty acids", "zyklische Fettsaeuren" ; oboInOwl:id "CHEBI:59238" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cyclic fatty acid" ; rdfs:subClassOf obo:CHEBI_35366 . obo:CHEBI_59252 obo:IAO_0000115 "An organic anion arising from deprotonation of a acyclic tetrapyrrole compound." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acyclic tetrapyrrole anion", "acyclic tetrapyrrole anions", "linear tetrapyrrole anions" ; oboInOwl:id "CHEBI:59252" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "linear tetrapyrrole anion" ; rdfs:subClassOf obo:CHEBI_25696 . obo:CHEBI_59266 obo:IAO_0000115 "An amino oligosaccharide that is a trisaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino trisaccharides" ; oboInOwl:id "CHEBI:59266" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino trisaccharide" ; rdfs:subClassOf obo:CHEBI_22483, obo:CHEBI_63571 . obo:CHEBI_5931 obo:IAO_0000115 "An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes." ; chebi:charge "0" ; chebi:formula "C257H383N65O77S6" ; chebi:inchi "InChI=1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1" ; chebi:inchikey "PBGKTOXHQIOBKM-FHFVDXKLSA-N" ; chebi:mass "5807.630" ; chebi:monoisotopicmass "5803.63765" ; chebi:smiles "CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC3=CC=CC=C3)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CNC=N3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)CC" ; oboInOwl:hasDbXref "CAS:11061-68-0", "DrugBank:DB00030", "KEGG:C00723", "KEGG:D00085", "PMID:22249812", "PMID:22617471", "PMID:22715632", "PMID:22843207", "PMID:31301295", "PMID:31821343", "PMID:31876563", "PMID:32208558", "PMID:32398693", "PMID:32629793", "PMID:32797824", "PMID:8019699" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Exubera", "Insulin", "Insulin recombinant", "human insulin", "insulin (recombinant)", "insulin human", "insulina humana", "insuline humaine", "insulinum humanum" ; oboInOwl:id "CHEBI:5931" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "insulin (human)" ; rdfs:subClassOf obo:CHEBI_145810, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35526 ] . obo:CHEBI_59326 obo:IAO_0000115 "A prostanoid anion obtained by deprotonation of the carboxy group of any prostaglandin." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prostaglandin carboxylic acid anions" ; oboInOwl:id "CHEBI:59326" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostaglandin carboxylic acid anion" ; rdfs:subClassOf obo:CHEBI_28868, obo:CHEBI_62943, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26333 ] . obo:CHEBI_59554 obo:IAO_0000115 "Any fatty acid with a chain length of between C6 and C12." ; chebi:charge "0" ; chebi:formula "CHO2R" ; chebi:mass "45.01740" ; chebi:monoisotopicmass "44.99765" ; chebi:smiles "OC([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "MCFA", "MCFAs", "medium-chain fatty acids" ; oboInOwl:id "CHEBI:59554" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "medium-chain fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59558 ] . obo:CHEBI_59558 obo:IAO_0000115 "A fatty acid anion resulting from the deprotonation of the carboxylic acid moiety of a medium-chain fatty acid." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "MCFA anion", "MCFA anions", "a medium chain fatty acid", "medium-chain FA anion", "medium-chain FA anions", "medium-chain fatty acid anions" ; oboInOwl:id "CHEBI:59558" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "medium-chain fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_59554 ] . obo:CHEBI_59561 obo:IAO_0000115 "An organic anion that is the conjugate base of diamino acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "diamino acid anions" ; oboInOwl:id "CHEBI:59561" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "diamino acid anion" ; rdfs:subClassOf obo:CHEBI_25696, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35987 ] . obo:CHEBI_59644 obo:IAO_0000115 "Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group." ; oboInOwl:hasDbXref "PMID:6434570", "PMID:8454196", "PMID:8638935" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo fatty acids" ; oboInOwl:id "CHEBI:59644" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo fatty acid" ; rdfs:subClassOf obo:CHEBI_25754, obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_59836 ] . obo:CHEBI_59698 obo:IAO_0000115 "Compounds containing one or more phosphoric acid units." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:59698" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "phosphoric acids" ; rdfs:subClassOf obo:CHEBI_33457 . obo:CHEBI_59740 obo:IAO_0000115 "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "nucleophile", "nucleophiles", "nucleophilic reagents" ; oboInOwl:id "CHEBI:59740" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nucleophilic reagent" ; rdfs:subClassOf obo:CHEBI_33893, obo:CHEBI_39144 . obo:CHEBI_59814 obo:IAO_0000115 "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." ; chebi:charge "-1" ; chebi:formula "C2H3NO2R" ; chebi:mass "73.051" ; chebi:monoisotopicmass "73.01638" ; chebi:smiles "[C@H](C(=O)[O-])(N)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-alpha-amino carboxylate" ; oboInOwl:id "CHEBI:59814" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-alpha-amino acid anion" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15705 ] . obo:CHEBI_59826 obo:IAO_0000115 "A synthetic progestogen." ; oboInOwl:hasDbXref "Wikipedia:Progestin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "progestins" ; oboInOwl:id "CHEBI:59826" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "progestin" ; rdfs:subClassOf obo:CHEBI_50745 . obo:CHEBI_59835 obo:IAO_0000115 "The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "OH-FA anion", "OH-FA-anions", "OH-fatty acid anion", "OH-fatty acid anions", "hydroxy fatty acid anions" ; oboInOwl:id "CHEBI:59835" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxy fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, obo:CHEBI_36059, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_24654 ] . obo:CHEBI_59836 obo:IAO_0000115 "A fatty acid anion carrying one or more oxo substituents" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxo fatty acid anions", "oxo-FA anion", "oxo-FA anions" ; oboInOwl:id "CHEBI:59836" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxo fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868, obo:CHEBI_35903, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_59644 ] . obo:CHEBI_59845 obo:IAO_0000115 "Any fatty acid with a hydroxy functional group in the beta- or 3-position. beta-Hydroxy fatty acids accumulate during cardiac hypoxia, and can also be used as chemical markers of bacterial endotoxins." ; chebi:charge "0" ; chebi:formula "C3H5O3R" ; chebi:mass "89.07000" ; chebi:monoisotopicmass "89.02387" ; chebi:smiles "OC([*])CC(O)=O" ; oboInOwl:hasDbXref "PMID:1226425", "PMID:17392575", "PMID:3094448", "PMID:7406063" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-OH fatty acid", "3-OH fatty acids", "3-hydroxy fatty acids", "beta-OH fatty acid", "beta-OH fatty acids", "beta-hydroxy fatty acid", "beta-hydroxy fatty acids" ; oboInOwl:id "CHEBI:59845" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy fatty acid" ; rdfs:subClassOf obo:CHEBI_24654, obo:CHEBI_35969, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_84196 ] . obo:CHEBI_59869 obo:IAO_0000115 "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "[NH3+][C@@H]([*])C([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-alpha-amino acid zwitterions", "an L-alpha-amino acid" ; oboInOwl:id "CHEBI:59869" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-alpha-amino acid zwitterion" ; rdfs:subClassOf obo:CHEBI_78608, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15705 ] . obo:CHEBI_59871 obo:IAO_0000115 "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "[NH3+][C@H]([*])C([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-alpha-amino acid zwitterions", "a D-alpha-amino acid" ; oboInOwl:id "CHEBI:59871" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-alpha-amino acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16733 ] . obo:CHEBI_59874 obo:IAO_0000115 "A carboxylic acid anion that is the conjugate base of an N-acyl-L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H2NO3R2" ; chebi:mass "100.05290" ; chebi:monoisotopicmass "100.00347" ; chebi:smiles "[O-]C(=O)[C@H]([*])NC([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acyl-L-alpha-amino acid(1-)", "an N-acyl-L-amino acid" ; oboInOwl:id "CHEBI:59874" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-L-alpha-amino acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_59814 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_48927 ] . obo:CHEBI_59876 obo:IAO_0000115 "The conjugate base of an N-acyl-D-alpha-amino acid arising from deprotonation of the C-1 carboxy group." ; chebi:charge "-1" ; chebi:formula "C3H2NO3R2" ; chebi:mass "100.05290" ; chebi:monoisotopicmass "100.00347" ; chebi:smiles "[O-]C(=O)[C@@H]([*])NC([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acyl-D-alpha-amino acid(1-)", "an N-acyl-D-amino acid" ; oboInOwl:id "CHEBI:59876" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acyl-D-alpha-amino acid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15778 ] . obo:CHEBI_59888 obo:IAO_0000115 "Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group." ; chebi:charge "0" ; chebi:formula "C4H9NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)" ; chebi:inchikey "BTCSSZJGUNDROE-UHFFFAOYSA-N" ; chebi:mass "103.11980" ; chebi:monoisotopicmass "103.06333" ; chebi:smiles "[NH3+]CCCC([O-])=O" ; oboInOwl:hasDbXref "Gmelin:1041559" ; oboInOwl:hasExactSynonym "4-azaniumylbutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-aminobutanoate", "4-ammoniobutanoate" ; oboInOwl:id "CHEBI:59888" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-aminobutyric acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16865 ] . obo:CHEBI_59905 obo:IAO_0000115 "An ammonium ion that is the conjugate acid of dopamine; major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "C8H12NO2" ; chebi:inchi "InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1" ; chebi:inchikey "VYFYYTLLBUKUHU-UHFFFAOYSA-O" ; chebi:mass "154.18640" ; chebi:monoisotopicmass "154.08626" ; chebi:smiles "[NH3+]CCc1ccc(O)c(O)c1" ; oboInOwl:hasDbXref "Gmelin:328863" ; oboInOwl:hasExactSynonym "2-(3,4-dihydroxyphenyl)ethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-(3,4-dihydroxyphenyl)ethan-1-aminium", "dopamine", "dopaminium cation" ; oboInOwl:id "CHEBI:59905" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dopaminium(1+)" ; rdfs:subClassOf obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_18243 ] . obo:CHEBI_59999 obo:IAO_0000115 "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Chemische Substanz" ; oboInOwl:id "CHEBI:59999" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chemical substance" ; rdfs:subClassOf obo:CHEBI_24431 . obo:CHEBI_60004 obo:IAO_0000115 "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Mischung" ; oboInOwl:id "CHEBI:60004" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mixture" ; rdfs:subClassOf obo:CHEBI_59999 . obo:CHEBI_60027 obo:IAO_0000115 "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." ; oboInOwl:hasDbXref "Wikipedia:Polymer" ; oboInOwl:hasExactSynonym "Polymer" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Kunststoff" ; oboInOwl:id "CHEBI:60027" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polymer" ; rdfs:subClassOf obo:CHEBI_60004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_33839 ] . obo:CHEBI_60039 obo:IAO_0000115 "The zwitterion formed from L-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH." ; chebi:charge "0" ; chebi:formula "C5H9NO2" ; chebi:inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" ; chebi:inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-N" ; chebi:mass "115.13050" ; chebi:monoisotopicmass "115.06333" ; chebi:smiles "[O-]C(=O)[C@@H]1CCC[NH2+]1" ; oboInOwl:hasAlternativeId "CHEBI:58054" ; oboInOwl:hasDbXref "MetaCyc:PRO" ; oboInOwl:hasExactSynonym "(2S)-pyrrolidinium-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-proline" ; oboInOwl:id "CHEBI:60039" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-proline zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_17203 ] . obo:CHEBI_60059 obo:IAO_0000115 "A carbohydrate acid derivative anion obtained from dermatan by deprotonation of the carboxylic acid groups of the repeating units; the major species at pH 7.3." ; chebi:formula "H2O(C14H20NO11)n" ; oboInOwl:hasAlternativeId "CHEBI:58701" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dermatan", "dermatan polyanion" ; oboInOwl:id "CHEBI:60059" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dermatan anion" ; rdfs:subClassOf obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_4439 ] . obo:CHEBI_60065 obo:IAO_0000115 "A carbohydrate acid derivative anion that is the conjugate base of alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C42H72N2O21R" ; chebi:mass "941.02190" ; chebi:monoisotopicmass "940.46276" ; chebi:smiles "CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]2O)[C@H](O)[C@H]1O)NC([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide", "ganglioside GM3 (d18:1(4E))" ; oboInOwl:id "CHEBI:60065" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine(1-)" ; rdfs:subClassOf obo:CHEBI_35757, obo:CHEBI_79210, obo:CHEBI_88071, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15681 ] . obo:CHEBI_60073 obo:IAO_0000115 "A sialic acid anion arising from deprotonation of the carboxy group of an N-acylneuraminic acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C10H15NO9R" ; chebi:mass "293.22740" ; chebi:monoisotopicmass "293.07468" ; chebi:smiles "[H][C@]1(OC(O)(C[C@H](O)[C@H]1NC([*])=O)C([O-])=O)[C@H](O)[C@H](O)CO" ; oboInOwl:hasExactSynonym "5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-acylneuraminate cation", "an N-acylneuraminate" ; oboInOwl:id "CHEBI:60073" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acylneuraminate" ; rdfs:subClassOf obo:CHEBI_29067, obo:CHEBI_62944, obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16498 ] . obo:CHEBI_60164 obo:IAO_0000115 "An ionic polymer is a polymer, composed of ionic macromolecules." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyionic polymer" ; oboInOwl:id "CHEBI:60164" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ionic polymer" ; rdfs:subClassOf obo:CHEBI_60027, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_53368 ] . obo:CHEBI_60242 obo:IAO_0000115 "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a monovalent cation" ; oboInOwl:id "CHEBI:60242" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monovalent inorganic cation" ; rdfs:subClassOf obo:CHEBI_36915 . obo:CHEBI_60308 obo:IAO_0000115 "The anion resulting from the removal of the proton from the carboxylic acid group of 3,3',5-triiodo-L-thyronine." ; chebi:charge "-1" ; chebi:formula "C15H11I3NO4" ; chebi:inchi "InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/p-1/t12-/m0/s1" ; chebi:inchikey "AUYYCJSJGJYCDS-LBPRGKRZSA-M" ; chebi:mass "649.96560" ; chebi:monoisotopicmass "649.78277" ; chebi:smiles "N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O" ; oboInOwl:hasExactSynonym "(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propionate", "3,3',5-triiodo-L-thyronine anion", "3,3',5-triiodo-L-thyronine(1-)", "liothyronine anion", "liothyronine(1-)" ; oboInOwl:id "CHEBI:60308" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3,3',5-triiodo-L-thyroninate" ; rdfs:subClassOf obo:CHEBI_33558, obo:CHEBI_35757, obo:CHEBI_63477, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18258 ] . obo:CHEBI_60311 obo:IAO_0000115 "Any hormone produced by the thyroid gland" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "thyroid hormones" ; oboInOwl:id "CHEBI:60311" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "thyroid hormone" ; rdfs:subClassOf obo:CHEBI_24621 . obo:CHEBI_60466 obo:IAO_0000115 "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." ; chebi:charge "0" ; chebi:formula "C2H4NO2R(C2H2NOR)n" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a peptide", "peptide zwitterions" ; oboInOwl:id "CHEBI:60466" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "peptide zwitterion" ; rdfs:subClassOf obo:CHEBI_27369, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16670 ] . obo:CHEBI_60525 obo:IAO_0000115 "Molybdenum cofactor MoCo protonated to pH 7.3." ; chebi:charge "-2" ; chebi:formula "C10H11MoN5O8PS3" ; chebi:mass "552.33000" ; chebi:monoisotopicmass "553.85615" ; chebi:smiles "C1(NC(=NC2=C1N[C@]3(C4=C([C@H](O[C@]3(N2)[H])COP([O-])([O-])=O)S[Mo](S4)(=O)(O)S*)[H])N)=O" ; oboInOwl:hasDbXref "PDB:3HBG", "PDB:3HBP", "PDB:3HBQ", "PDBeChem:MSS", "PMID:20356030" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "MoCo" ; oboInOwl:id "CHEBI:60525" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "molybdenum cofactor(2-)" ; rdfs:subClassOf obo:CHEBI_64775, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_79026 ] . obo:CHEBI_606564 obo:IAO_0000115 "The conjugate base of prostaglandin E2; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C20H31O5" ; chebi:inchi "InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1" ; chebi:inchikey "XEYBRNLFEZDVAW-ARSRFYASSA-M" ; chebi:mass "351.45710" ; chebi:monoisotopicmass "351.21770" ; chebi:smiles "CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1C\\C=C/CCCC([O-])=O" ; oboInOwl:hasDbXref "Beilstein:8364130", "MetaCyc:5Z13E-15S-1115-DIHYDROXY-9-OXOPROS" ; oboInOwl:hasExactSynonym "(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prostaglandin E2", "prostaglandin E2 anion" ; oboInOwl:id "CHEBI:606564" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostaglandin E2(1-)" ; rdfs:subClassOf obo:CHEBI_59326, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_36063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15551 ] . obo:CHEBI_606565 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of N-benzoylglycine; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C9H8NO3" ; chebi:inchi "InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)/p-1" ; chebi:inchikey "QIAFMBKCNZACKA-UHFFFAOYSA-M" ; chebi:mass "178.16470" ; chebi:monoisotopicmass "178.05097" ; chebi:smiles "[O-]C(=O)CNC(=O)c1ccccc1" ; oboInOwl:hasAlternativeId "CHEBI:24594" ; oboInOwl:hasDbXref "Beilstein:3610359", "Gmelin:329632", "MetaCyc:CPD-425", "PMID:22153801", "Reaxys:3610359" ; oboInOwl:hasExactSynonym "(benzoylamino)acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-benzamidoacetate", "N-benzoylglycinate anion", "N-benzoylglycinate(1-)", "N-benzoylglycine", "hippurate" ; oboInOwl:id "CHEBI:606565" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-benzoylglycinate" ; rdfs:subClassOf obo:CHEBI_132966, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18089 ] . obo:CHEBI_60895 obo:IAO_0000115 "Any alpha-amino acid anion in which the parent amino acid has D-configuration." ; chebi:charge "-1" ; chebi:formula "C2H3NO2R" ; chebi:mass "73.051" ; chebi:monoisotopicmass "73.01638" ; chebi:smiles "[C@@H](C(=O)[O-])(N)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-alpha-amino acid anions", "D-alpha-amino carboxylate" ; oboInOwl:id "CHEBI:60895" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-alpha-amino acid anion" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16733 ] . obo:CHEBI_60911 obo:IAO_0000115 "A racemate is an equimolar mixture of a pair of enantiomers." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "melange racemique", "racemates", "racemic mixture" ; oboInOwl:id "CHEBI:60911" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "racemate" ; rdfs:subClassOf obo:CHEBI_60004 . obo:CHEBI_60924 obo:IAO_0000115 "A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-beta-Gal-(1->4)-beta-GlcNAc-(1->] and containing sulfo groups located at random positions." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "keratan sulfates", "keratosulfate" ; oboInOwl:id "CHEBI:60924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "keratan sulfate" ; rdfs:subClassOf obo:CHEBI_35722, obo:CHEBI_37395, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_29057 ] . obo:CHEBI_60948 obo:IAO_0000115 "A linear trisaccharide comprising D-glucose (at the reducing end) having an alpha-D-galactosyl-(1->4)-beta-D-galactosyl moiety at the 4-position." ; chebi:charge "0" ; chebi:formula "C18H32O16" ; chebi:inchi "InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7+,8+,9-,10-,11-,12-,13-,14-,15+,16?,17-,18+/m1/s1" ; chebi:inchikey "FYGDTMLNYKFZSV-ANKSBSNASA-N" ; chebi:mass "504.43710" ; chebi:monoisotopicmass "504.16903" ; chebi:smiles "OC[C@H]1O[C@H](O[C@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O" ; oboInOwl:hasDbXref "CAS:80446-87-3", "GlyGen:G06000DZ", "GlyTouCan:G06000DZ", "KEGG:G03416", "PMID:12020649", "PMID:16133831", "PMID:17991151", "PMID:2292729", "PMID:2456994", "PMID:9538266", "Reaxys:5386141" ; oboInOwl:hasExactSynonym "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-D-glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(Gal)2 (Glc)1", "4'-galactosyllactose", "4-O-(4-O-alpha-D-galactopyranosyl-beta-D-galactopyranosyl)-D-glucopyranose", "Gal-alpha-1,4-Gal-beta-1,4-Glc", "Gal-alpha1,4Gal-beta1,4-Glc", "Galalpha1,4Gal-beta1,4Glc", "Galalpha1-4Gal-beta1-4Glc", "Galalpha1-4Gal-beta1-4Glc~OH", "Pk", "WURCS=2.0/3,3,2/[a2122h-1x_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1", "alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp", "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucose" ; oboInOwl:id "CHEBI:60948" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc" ; rdfs:subClassOf obo:CHEBI_27150 . obo:CHEBI_61115 obo:IAO_0000115 "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98)." ; oboInOwl:hasDbXref "Wikipedia:Histone_deacetylase_inhibitor" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.5.1.98 (histone deacetylase) inhibitors", "EC 3.5.1.98 inhibitor", "EC 3.5.1.98 inhibitors", "HDAC inhibitor", "HDAC inhibitors", "HDACi", "HDACis", "HDI", "HDIs", "histone amidohydrolase inhibitor", "histone amidohydrolase inhibitors", "histone deacetylase (EC 3.5.1.98) inhibitor", "histone deacetylase (EC 3.5.1.98) inhibitors", "histone deacetylase inhibitor", "histone deacetylase inhibitors" ; oboInOwl:id "CHEBI:61115" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.5.1.98 (histone deacetylase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76807 . obo:CHEBI_61313 obo:IAO_0000115 "A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure." ; chebi:charge "0" ; chebi:formula "C21H36" ; chebi:inchi "InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3" ; chebi:inchikey "JWMFYGXQPXQEEM-UHFFFAOYSA-N" ; chebi:mass "288.511" ; chebi:monoisotopicmass "288.28170" ; chebi:smiles "C1CCCC2C1(C3C(CC2)C4C(CC3)(C(CC4)CC)C)C" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a C21-steroid" ; oboInOwl:id "CHEBI:61313" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C21-steroid" ; rdfs:subClassOf obo:CHEBI_35341 . obo:CHEBI_61336 obo:IAO_0000115 "A dicarboxylate that contains four carbon atoms." ; chebi:charge "-2" ; chebi:formula "C2O4R" ; chebi:mass "88.019" ; chebi:monoisotopicmass "87.97966" ; chebi:smiles "[O-]C(=O)[*]C([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:61336" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C4-dicarboxylate" ; rdfs:subClassOf obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_66873 ] . obo:CHEBI_61355 obo:IAO_0000115 "Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-hydroxy carboxylic acids", "3-hydroxycarboxylic acid", "3-hydroxycarboxylic acids", "beta-hydroxy carboxylic acid", "beta-hydroxy carboxylic acids", "beta-hydroxycarboxylic acid", "beta-hydroxycarboxylic acids" ; oboInOwl:id "CHEBI:61355" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy carboxylic acid" ; rdfs:subClassOf obo:CHEBI_24669 . obo:CHEBI_61360 obo:IAO_0000115 "Any glycosphingolipid where the oligosaccharide component has an N-acetylgalactosaminyl residue at the non-reducing end." ; oboInOwl:hasDbXref "Wikipedia:Globoside" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "globosides" ; oboInOwl:id "CHEBI:61360" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "globoside" ; rdfs:subClassOf obo:CHEBI_24402 . obo:CHEBI_61409 obo:IAO_0000115 "A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents." ; oboInOwl:hasAlternativeId "CHEBI:23787" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dihydroxyphenylacetic acids" ; oboInOwl:id "CHEBI:61409" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dihydroxyphenylacetic acid" ; rdfs:subClassOf obo:CHEBI_25978, obo:CHEBI_35972 . obo:CHEBI_61469 obo:IAO_0000115 "A polymer, composed of polyanion macromolecules." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polyanion", "polyanions" ; oboInOwl:id "CHEBI:61469" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polyanionic polymer" ; rdfs:subClassOf obo:CHEBI_60164, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_53309 ] . obo:CHEBI_61660 obo:IAO_0000115 "An anion resulting from the removal of a proton from an organic sulfamic acid group." ; chebi:charge "-1" ; chebi:formula "NO3SR2" ; chebi:mass "94.07000" ; chebi:monoisotopicmass "93.95989" ; chebi:smiles "[O-]S(=O)(=O)N([*])[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an organic sulfamic acid anion", "organic sulfamic acid anions" ; oboInOwl:id "CHEBI:61660" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic sulfamate oxoanion" ; rdfs:subClassOf obo:CHEBI_25696, obo:CHEBI_33482 . obo:CHEBI_61697 obo:IAO_0000115 "Any organic molecular entity derived from a fatty acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "FA derivative", "FA derivatives", "fatty acid derivatives" ; oboInOwl:id "CHEBI:61697" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid derivative" ; rdfs:subClassOf obo:CHEBI_18059, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35366 ] . obo:CHEBI_62031 obo:IAO_0000115 "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "C(C([O-])=O)(*)[NH3+]" ; oboInOwl:hasDbXref "MetaCyc:Polar-amino-acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a polar amino acid" ; oboInOwl:id "CHEBI:62031" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "polar amino acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_26167 ] . obo:CHEBI_62081 obo:IAO_0000115 "An alkanesulfonate in which the carbon at position 1 is attached to at least two hydrogens." ; chebi:charge "-1" ; chebi:formula "CH2O3SR" ; chebi:mass "94.09000" ; chebi:monoisotopicmass "93.97246" ; chebi:smiles "[H]C([H])([*])S([O-])(=O)=O" ; oboInOwl:hasDbXref "KEGG:C15521", "MetaCyc:Alkanesulfonates" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,1-di-unsubstituted alkanesulfonate", "1,1-di-unsubstituted alkanesulfonates", "1,1-diunsubstituted alkanesulfonates" ; oboInOwl:id "CHEBI:62081" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1,1-diunsubstituted alkanesulfonate" ; rdfs:subClassOf obo:CHEBI_134249, obo:CHEBI_33554, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35703 ] . obo:CHEBI_62488 obo:IAO_0000115 "A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "signal molecule", "signal molecules", "signaling molecule", "signaling molecules", "signalling molecules" ; oboInOwl:id "CHEBI:62488" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "signalling molecule" ; rdfs:subClassOf obo:CHEBI_33280 . obo:CHEBI_62499 obo:IAO_0000115 "Any branched-chain fatty acid containing methyl branches only." ; oboInOwl:hasDbXref "PMID:17030019", "PMID:19747846", "PMID:19933331" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methyl-branched fatty acids" ; oboInOwl:id "CHEBI:62499" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methyl-branched fatty acid" ; rdfs:subClassOf obo:CHEBI_35819, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_67013 ] . obo:CHEBI_62501 obo:IAO_0000115 "The dicarboxylic acid dianion formed from folic acid by loss of a proton from each of the two carboxy groups in the glutamic acid moiety." ; chebi:charge "-2" ; chebi:formula "C19H17N7O6" ; chebi:inchi "InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/p-2/t12-/m0/s1" ; chebi:inchikey "OVBPIULPVIDEAO-LBPRGKRZSA-L" ; chebi:mass "439.38160" ; chebi:monoisotopicmass "439.12513" ; chebi:smiles "Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)nc2c(=O)[nH]1" ; oboInOwl:hasDbXref "MetaCyc:CPD-12826", "PMCID:PMC8181341", "PMID:34051149" ; oboInOwl:hasExactSynonym "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate(2-)" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "folate", "pteroyl-L-glutamate", "pteroyl-L-monoglutamate", "pteroylglutamate" ; oboInOwl:id "CHEBI:62501" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "folate(2-)" ; rdfs:subClassOf obo:CHEBI_28965, obo:CHEBI_67011, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_27470 ] . obo:CHEBI_62643 obo:IAO_0000115 "Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1-), phosphatidate(2-), phosphatidylglycerol(1-)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anionic phospholipids", "phospholipid anion", "phospholipid anions" ; oboInOwl:id "CHEBI:62643" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anionic phospholipid" ; rdfs:subClassOf obo:CHEBI_58945, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16247 ] . obo:CHEBI_62761 obo:IAO_0000115 "An amino acid derivative resulting from reaction of tyrosine at the amino group or the carboxy group, any substitution of phenyl hydrogens, or from the replacement of any hydrogen of tyrosine by a heteroatom. The definition normally excludes peptides containing tyrosine residues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tyrosine derivatives" ; oboInOwl:id "CHEBI:62761" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tyrosine derivative" ; rdfs:subClassOf obo:CHEBI_25985, obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_18186 ] . obo:CHEBI_62803 obo:IAO_0000115 "Any additive that enhances the efficiency of fuel." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fuel additives", "fuel enhancer" ; oboInOwl:id "CHEBI:62803" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fuel additive" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_62868 obo:IAO_0000115 "Any compound that is able to prevent damage to the liver." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antihepatotoxic agent", "hepatoprotective agents", "hepatoprotector" ; oboInOwl:id "CHEBI:62868" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hepatoprotective agent" ; rdfs:subClassOf obo:CHEBI_50267 . obo:CHEBI_62937 obo:IAO_0000115 "The carboxylic acid anion that is the conjugate base of an icosanoid, formed when the carboxy group is deprotonated." ; oboInOwl:hasExactSynonym "icosanoid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "eicosanoid anion", "eicosanoid anions", "icosanoid anions" ; oboInOwl:id "CHEBI:62937" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "icosanoid anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_23899 ] . obo:CHEBI_62943 obo:IAO_0000115 "An icosanoid anion that is the conjugate base of a prostanoid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prostanoid anions" ; oboInOwl:id "CHEBI:62943" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostanoid anion" ; rdfs:subClassOf obo:CHEBI_2580, obo:CHEBI_62937, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26347 ] . obo:CHEBI_62944 obo:IAO_0000115 "A carboxylic acid anion that is the conjugate base of a sialic acid, formed by deprotonation of the carboxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sialic acid anions" ; oboInOwl:id "CHEBI:62944" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sialic acid anion" ; rdfs:subClassOf obo:CHEBI_29067, obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26667 ] . obo:CHEBI_62978 obo:IAO_0000115 "The alpha-amino-acid anion formed by loss of a proton from the carboxy group of 4-hydroxyproline." ; chebi:charge "-1" ; chebi:formula "C5H8NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/p-1" ; chebi:inchikey "PMMYEEVYMWASQN-UHFFFAOYSA-M" ; chebi:mass "130.12190" ; chebi:monoisotopicmass "130.05097" ; chebi:smiles "OC1CNC(C1)C([O-])=O" ; oboInOwl:hasExactSynonym "4-hydroxypyrrolidine-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-hydroxyproline anion", "hydroxyprolinate", "hydroxyproline anion" ; oboInOwl:id "CHEBI:62978" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyprolinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_20392 ] . obo:CHEBI_62981 obo:IAO_0000115 "The L-alpha-amino acid anion that is the conjugate base of 4-hydroxy-L-proline, formed by proton loss from the carboxy group. It is the major microspecies present at pH > 10.6." ; chebi:charge "-1" ; chebi:formula "C5H8NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/p-1/t3?,4-/m0/s1" ; chebi:inchikey "PMMYEEVYMWASQN-BKLSDQPFSA-M" ; chebi:mass "130.12190" ; chebi:monoisotopicmass "130.05097" ; chebi:smiles "OC1CN[C@@H](C1)C([O-])=O" ; oboInOwl:hasDbXref "Reaxys:4742919" ; oboInOwl:hasExactSynonym "(2S)-4-hydroxypyrrolidine-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "4-hydroxy-L-proline anion" ; oboInOwl:id "CHEBI:62981" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxy-L-prolinate" ; rdfs:subClassOf obo:CHEBI_59814, obo:CHEBI_62978, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18240 ] . obo:CHEBI_63046 obo:IAO_0000115 "The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "emulgent", "emulgents", "emulsifiers" ; oboInOwl:id "CHEBI:63046" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "emulsifier" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_63070 obo:IAO_0000115 "A beta-amino-acid anion that is the conjugate base of beta-alanine." ; chebi:charge "-1" ; chebi:formula "C3H6NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)/p-1" ; chebi:inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-M" ; chebi:mass "88.08520" ; chebi:monoisotopicmass "88.04040" ; chebi:smiles "NCCC([O-])=O" ; oboInOwl:hasDbXref "Reaxys:3536336" ; oboInOwl:hasExactSynonym "3-aminopropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-alaninate anion", "beta-alaninate(1-)" ; oboInOwl:id "CHEBI:63070" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "beta-alaninate" ; rdfs:subClassOf obo:CHEBI_49095, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_78675 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16958 ] . obo:CHEBI_63137 obo:IAO_0000115 "The amino acid zwitterion formed from 4-hydroxyproline." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:inchi "InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)" ; chebi:inchikey "PMMYEEVYMWASQN-UHFFFAOYSA-N" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; chebi:smiles "OC1C[NH2+]C(C1)C([O-])=O" ; oboInOwl:hasExactSynonym "4-hydroxypyrrolidinium-2-carboxylate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:63137" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "4-hydroxyproline zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_20392 ] . obo:CHEBI_63161 obo:IAO_0000115 "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycosyl compounds" ; oboInOwl:id "CHEBI:63161" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycosyl compound" ; rdfs:subClassOf obo:CHEBI_63299 . obo:CHEBI_63248 obo:IAO_0000115 "A substance that removes electrons from another reactant in a redox reaction." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "oxidant", "oxidants", "oxidiser", "oxidisers", "oxidising agents", "oxidizer", "oxidizers", "oxidizing agent", "oxidizing agents" ; oboInOwl:id "CHEBI:63248" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oxidising agent" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_63299 obo:IAO_0000115 "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate derivatives", "derivatised carbohydrate", "derivatised carbohydrates", "derivatized carbohydrate", "derivatized carbohydrates" ; oboInOwl:id "CHEBI:63299" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate derivative" ; rdfs:subClassOf obo:CHEBI_78616, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16646 ] . obo:CHEBI_63353 obo:IAO_0000115 "A carbohydrate derivative that is formally obtained from a disaccharide." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "disaccharide derivatives" ; oboInOwl:id "CHEBI:63353" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "disaccharide derivative" ; rdfs:subClassOf obo:CHEBI_63299, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_36233 ] . obo:CHEBI_63367 obo:IAO_0000115 "A carbohydrate derivative that is formally obtained from a monosaccharide." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monosaccharide derivatives" ; oboInOwl:id "CHEBI:63367" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monosaccharide derivative" ; rdfs:subClassOf obo:CHEBI_63299, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_35381 ] . obo:CHEBI_63394 obo:IAO_0000115 "A monosaccharide derivative that is formally obtained from a ketoaldonic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ketoaldonic acid derivatives" ; oboInOwl:id "CHEBI:63394" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ketoaldonic acid derivative" ; rdfs:subClassOf obo:CHEBI_63367, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_24963 ] . obo:CHEBI_63436 obo:IAO_0000115 "A carbohydrate derivative that is formally obtained from a carbohydrate acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate acid derivatives" ; oboInOwl:id "CHEBI:63436" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate acid derivative" ; rdfs:subClassOf obo:CHEBI_63299, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_33720 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_63551 ] . obo:CHEBI_63470 obo:IAO_0000115 "A sulfur-containing amino acid whose alpha-carboxylic acid group is ionized (not protonated)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "sulfur-containing amino-acid anions" ; oboInOwl:id "CHEBI:63470" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sulfur-containing amino-acid anion" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26834 ] . obo:CHEBI_63471 obo:IAO_0000115 "A branched-chain amino acid whose alpha-carboxylic acid group is ionized." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "branched-chain amino-acid anions" ; oboInOwl:id "CHEBI:63471" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "branched-chain amino-acid anion" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_22918 ] . obo:CHEBI_63473 obo:IAO_0000115 "An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aromatic amino-acid anions" ; oboInOwl:id "CHEBI:63473" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic amino-acid anion" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33856 ] . obo:CHEBI_63477 obo:IAO_0000115 "An iodothyronine whose alpha carboxylic acid group of the tyrosine is ionized (not protonated)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "iodothyroninates" ; oboInOwl:id "CHEBI:63477" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "iodothyroninate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_24864 ] . obo:CHEBI_63533 obo:IAO_0000115 "Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response." ; oboInOwl:hasDbXref "Wikipedia:Gonadotropin-releasing_hormone_agonist" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "GnRH agonist", "GnRH agonists", "GnRH-A", "gonadotrophin releasing hormone agonist", "gonadotrophin releasing hormone agonists", "gonadotropin releasing hormone agonists" ; oboInOwl:id "CHEBI:63533" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gonadotropin releasing hormone agonist" ; rdfs:subClassOf obo:CHEBI_51060 . obo:CHEBI_63534 obo:IAO_0000115 "An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes." ; oboInOwl:hasDbXref "PMID:21822758", "PMID:21993877", "PMID:22005599", "PMID:22082101", "PMID:22153577", "PMID:22213370", "PMID:22218931", "PMID:22342987", "PMID:22371656" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monoamines", "naturally occurring monoamine", "naturally occurring monoamines" ; oboInOwl:id "CHEBI:63534" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monoamine" ; rdfs:subClassOf obo:CHEBI_64365 . obo:CHEBI_63551 obo:IAO_0000115 "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrate acid anion derivative", "carbohydrate acid anion derivatives", "carbohydrate acid derivative anions" ; oboInOwl:id "CHEBI:63551" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrate acid derivative anion" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_33721 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_63436 ] . obo:CHEBI_63561 obo:IAO_0000115 "A carbohydrate acid derivative anion that is formally obtained from a ketoaldonate." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ketoaldonate derivatives" ; oboInOwl:id "CHEBI:63561" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ketoaldonate derivative" ; rdfs:subClassOf obo:CHEBI_63551, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_24961 ] . obo:CHEBI_63563 obo:IAO_0000115 "A carbohydrate derivative that is formally obtained from an oligosaccharide." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "O-glycosylglycoside derivative", "O-glycosylglycoside derivatives", "oligosaccharide derivatives" ; oboInOwl:id "CHEBI:63563" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "oligosaccharide derivative" ; rdfs:subClassOf obo:CHEBI_167559, obo:CHEBI_63299, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_50699 ] . obo:CHEBI_63571 obo:IAO_0000115 "An oligosaccharide derivative that is formally obtained from a trisaccharide." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "trisaccharide derivatives" ; oboInOwl:id "CHEBI:63571" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trisaccharide derivative" ; rdfs:subClassOf obo:CHEBI_63563, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_27150 ] . obo:CHEBI_63726 obo:IAO_0000115 "Any compound that can be used for the treatment of neurodegenerative disorders." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "neuroprotectant", "neuroprotectants", "neuroprotective agents" ; oboInOwl:id "CHEBI:63726" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "neuroprotective agent" ; rdfs:subClassOf obo:CHEBI_50267 . obo:CHEBI_64047 obo:IAO_0000115 "Any substance which is added to food to preserve or enhance its flavour and/or appearance." ; oboInOwl:hasDbXref "Wikipedia:Food_additive" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food additives" ; oboInOwl:id "CHEBI:64047" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food additive" ; rdfs:subClassOf obo:CHEBI_33232, obo:CHEBI_78295 . obo:CHEBI_64049 obo:IAO_0000115 "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." ; oboInOwl:hasDbXref "Wikipedia:Acidity_regulator" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "acidity regulator", "acidity regulators", "food acidity regulators", "pH control agent", "pH control agents" ; oboInOwl:id "CHEBI:64049" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food acidity regulator" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_64365 obo:IAO_0000115 "An organic amino compound in which an aminoalkyl group is linked to an arene." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aralkylamino compounds" ; oboInOwl:id "CHEBI:64365" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aralkylamino compound" ; rdfs:subClassOf obo:CHEBI_50047 . obo:CHEBI_64390 obo:IAO_0000115 "An N-acylglycine in which the acyl group is specified as hexanoyl." ; chebi:charge "0" ; chebi:formula "C8H15NO3" ; chebi:inchi "InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)" ; chebi:inchikey "UPCKIPHSXMXJOX-UHFFFAOYSA-N" ; chebi:mass "173.20960" ; chebi:monoisotopicmass "173.10519" ; chebi:smiles "CCCCCC(=O)NCC(O)=O" ; oboInOwl:hasDbXref "CAS:24003-67-6", "HMDB:HMDB0000701", "PMID:17190852", "PMID:22770225", "Patent:EP226304", "Patent:EP415598", "Patent:EP517371", "Patent:EP572167", "Patent:EP580409", "Patent:US4757066", "Patent:US5112863", "Patent:US5238917", "Patent:US5559092", "Reaxys:1773416" ; oboInOwl:hasExactSynonym "N-hexanoylglycine", "n-Hexanoylglycine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Caproylglycine", "Hexanoylglycine", "N-(1-oxohexyl)glycine", "N-caproylglycine" ; oboInOwl:id "CHEBI:64390" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-hexanoylglycine" ; rdfs:subClassOf obo:CHEBI_16180, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_133580 ] . obo:CHEBI_64554 obo:IAO_0000115 "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tryptophan; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C11H12N2O2" ; chebi:inchi "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)" ; chebi:inchikey "QIVBCDIJIAJPQS-UHFFFAOYSA-N" ; chebi:mass "204.22520" ; chebi:monoisotopicmass "204.08988" ; chebi:smiles "[NH3+]C(Cc1c[nH]c2ccccc12)C([O-])=O" ; oboInOwl:hasExactSynonym "2-azaniumyl-3-(1H-indol-3-yl)propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammonio-3-(1H-indol-3-yl)propanoate" ; oboInOwl:id "CHEBI:64554" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tryptophan zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_27897 ] . obo:CHEBI_64558 obo:IAO_0000115 "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of methionine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C5H11NO2S" ; chebi:inchi "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)" ; chebi:inchikey "FFEARJCKVFRZRR-UHFFFAOYSA-N" ; chebi:mass "149.21100" ; chebi:monoisotopicmass "149.05105" ; chebi:smiles "CSCCC([NH3+])C([O-])=O" ; oboInOwl:hasExactSynonym "2-azaniumyl-4-(methylsulfanyl)butanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammonio-4-(methylsulfanyl)butanoate", "methionine" ; oboInOwl:id "CHEBI:64558" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methionine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16811 ] . obo:CHEBI_64570 obo:IAO_0000115 "An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of glycine hydroxymethyltransferase (EC 2.1.2.1)." ; oboInOwl:hasDbXref "Wikipedia:Glycine_hydroxymethyltransferase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitor", "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitors", "EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors", "EC 2.1.2.1 inhibitor", "EC 2.1.2.1 inhibitors", "L-serine hydroxymethyltransferase inhibitor", "L-serine hydroxymethyltransferase inhibitors", "L-threonine aldolase inhibitor", "L-threonine aldolase inhibitors", "allothreonine aldolase inhibitor", "allothreonine aldolase inhibitors", "glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitor", "glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitors", "glycine hydroxymethyltransferase inhibitor", "glycine hydroxymethyltransferase inhibitors", "serine aldolase inhibitor", "serine aldolase inhibitors", "serine hydroxymethylase inhibitor", "serine hydroxymethylase inhibitors", "serine hydroxymethyltransferase inhibitor", "serine hydroxymethyltransferase inhibitors", "serine transhydroxymethylase inhibitor", "serine transhydroxymethylase inhibitors", "threonine aldolase inhibitor", "threonine aldolase inhibitors" ; oboInOwl:id "CHEBI:64570" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76874 . obo:CHEBI_64571 obo:IAO_0000115 "An excitatory amino acid agonist which binds to NMDA receptors and triggers a response." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-methyl-D-aspartate receptor agonist", "N-methyl-D-aspartate receptor agonists", "NMDA receptor agonists", "NMDAR agonist", "NMDAR agonists" ; oboInOwl:id "CHEBI:64571" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "NMDA receptor agonist" ; rdfs:subClassOf obo:CHEBI_50103 . obo:CHEBI_64577 obo:IAO_0000115 "A food additive which is added to flour or dough to improve baking quality and/or colour." ; oboInOwl:hasDbXref "Wikipedia:Flour_treatment_agent" ; oboInOwl:hasExactSynonym "flour treatment agent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dough improver", "dough improvers", "improving agent", "improving agents" ; oboInOwl:id "CHEBI:64577" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "flour treatment agent" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_64584 obo:IAO_0000115 "A toxin that accumulates in patients with chronic kidney disease." ; oboInOwl:hasDbXref "Wikipedia:Uremic_toxin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "uremic toxins" ; oboInOwl:id "CHEBI:64584" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "uremic toxin" ; rdfs:subClassOf obo:CHEBI_27026 . obo:CHEBI_64588 obo:IAO_0000115 "Any glycine transporter inhibitor that interferes with the action of glycine 1 transporters." ; oboInOwl:hasDbXref "PMID:17504107", "PMID:18758757", "PMID:20678516", "PMID:21141920", "PMID:21531289", "PMID:22177408", "Wikipedia:Glycine_transporter_1" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "GlyT1 inhibitor", "GlyT1 inhibitors", "glycine transporter 1 inhibitors" ; oboInOwl:id "CHEBI:64588" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine transporter 1 inhibitor" ; rdfs:subClassOf obo:CHEBI_85425 . obo:CHEBI_64589 obo:IAO_0000115 "An agonist that binds to and activates glycine receptors" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycine receptor agonists" ; oboInOwl:id "CHEBI:64589" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine receptor agonist" ; rdfs:subClassOf obo:CHEBI_48705 . obo:CHEBI_64600 obo:IAO_0000115 "A steroid compound with a structure based on a 21-carbon (pregnane) skeleton that acts as a hormone." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C21-steroid hormones" ; oboInOwl:id "CHEBI:64600" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C21-steroid hormone" ; rdfs:subClassOf obo:CHEBI_26764, obo:CHEBI_61313 . obo:CHEBI_64708 obo:IAO_0000115 "An organic molecular entity containing a single carbon atom (C1)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "one-carbon compounds" ; oboInOwl:id "CHEBI:64708" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "one-carbon compound" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_64709 obo:IAO_0000115 "Any organic molecular entity that is acidic and contains carbon in covalent linkage." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic acids" ; oboInOwl:id "CHEBI:64709" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic acid" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_64767 obo:IAO_0000115 "A group that carries an overall negative charge." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anionic groups" ; oboInOwl:id "CHEBI:64767" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anionic group" ; rdfs:subClassOf obo:CHEBI_24433 . obo:CHEBI_64775 obo:IAO_0000115 "An anionic group that contains carbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic anionic groups" ; oboInOwl:id "CHEBI:64775" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic anionic group" ; rdfs:subClassOf obo:CHEBI_64767 . obo:CHEBI_64909 obo:IAO_0000115 "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." ; oboInOwl:hasDbXref "Wikipedia:Poison" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "poisonous agent", "poisonous agents", "poisonous substance", "poisonous substances", "poisons", "toxic agent", "toxic agents", "toxic substance", "toxic substances" ; oboInOwl:id "CHEBI:64909" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "poison" ; rdfs:subClassOf obo:CHEBI_24432 . obo:CHEBI_6495 obo:IAO_0000115 "A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." ; oboInOwl:hasDbXref "KEGG:C01834" ; oboInOwl:hasExactSynonym "Lipoprotein", "lipoproteins" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "lipoprotein particle" ; oboInOwl:id "CHEBI:6495" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "lipoprotein" ; rdfs:subClassOf obo:CHEBI_33837, obo:CHEBI_39024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_39015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76971 ] . obo:CHEBI_65023 obo:IAO_0000115 "Any compound that has anti-asthmatic effects." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-asthmatic agents", "antiasthmatic agent", "antiasthmatic agents" ; oboInOwl:id "CHEBI:65023" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anti-asthmatic agent" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_65212 obo:IAO_0000115 "A carbohydrate derivative that is any derivative of a polysaccharide." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "polysaccharide derivatives" ; oboInOwl:id "CHEBI:65212" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "polysaccharide derivative" ; rdfs:subClassOf obo:CHEBI_167559, obo:CHEBI_33694, obo:CHEBI_63299, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_18154 ] . obo:CHEBI_65255 obo:IAO_0000115 "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food preservatives" ; oboInOwl:id "CHEBI:65255" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food preservative" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_65256 obo:IAO_0000115 "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "antimicrobial food preservatives", "antimicrobial preservative", "antimicrobial preservatives" ; oboInOwl:id "CHEBI:65256" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antimicrobial food preservative" ; rdfs:subClassOf obo:CHEBI_33281, obo:CHEBI_65255 . obo:CHEBI_65296 obo:IAO_0000115 "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "H3NR" ; chebi:mass "17.031" ; chebi:monoisotopicmass "17.02655" ; chebi:smiles "[NH3+][*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a primary amine", "substituted ammonium" ; oboInOwl:id "CHEBI:65296" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "primary ammonium ion" ; rdfs:subClassOf obo:CHEBI_25697, obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_50994 ] . obo:CHEBI_66873 obo:IAO_0000115 "Any dicarboxylic acid that contains four carbon atoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C4-dicarboxylic acids" ; oboInOwl:id "CHEBI:66873" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "C4-dicarboxylic acid" ; rdfs:subClassOf obo:CHEBI_35692, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_61336 ] . obo:CHEBI_66874 obo:IAO_0000115 "An N-acyl-L-alpha-amino acid anion that is the conjugate base of carnosine, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C9H13N4O3" ; chebi:inchi "InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/p-1/t7-/m0/s1" ; chebi:inchikey "CQOVPNPJLQNMDC-ZETCQYMHSA-M" ; chebi:mass "225.22450" ; chebi:monoisotopicmass "225.09931" ; chebi:smiles "NCCC(=O)N[C@@H](Cc1c[nH]cn1)C([O-])=O" ; oboInOwl:hasDbXref "Reaxys:6337985" ; oboInOwl:hasExactSynonym "(2S)-2-(beta-alanylamino)-3-(1H-imidazol-4-yl)propanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N(alpha)-(beta-alanyl)-L-histidinate", "carnosinate anion", "carnosinate(1-)" ; oboInOwl:id "CHEBI:66874" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carnosinate" ; rdfs:subClassOf obo:CHEBI_59874, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15727 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_57485 ] . obo:CHEBI_66884 obo:IAO_0000115 "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of any N-alkylglycine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "[O-]C(=O)C[NH2+][*]" ; oboInOwl:hasDbXref "MetaCyc:N-Alkylglycine", "PMID:9989229" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an N-alkylglycine" ; oboInOwl:id "CHEBI:66884" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-alkylglycine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_57305 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_66933 ] . obo:CHEBI_66916 obo:IAO_0000115 "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of alanine; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C3H7NO2" ; chebi:inchi "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)" ; chebi:inchikey "QNAYBMKLOCPYGJ-UHFFFAOYSA-N" ; chebi:mass "89.09320" ; chebi:monoisotopicmass "89.04768" ; chebi:smiles "CC([NH3+])C([O-])=O" ; oboInOwl:hasExactSynonym "2-azaniumylpropanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-ammoniopropanoate" ; oboInOwl:id "CHEBI:66916" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alanine zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_16449 ] . obo:CHEBI_66922 obo:IAO_0000115 "An alpha-amino acid anion that is the conjugate base of citrulline, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C6H12N3O3" ; chebi:inchi "InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/p-1" ; chebi:inchikey "RHGKLRLOHDJJDR-UHFFFAOYSA-M" ; chebi:mass "174.17780" ; chebi:monoisotopicmass "174.08841" ; chebi:smiles "NC(CCCNC(N)=O)C([O-])=O" ; oboInOwl:hasExactSynonym "2-amino-5-(carbamoylamino)pentanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:66922" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "citrullinate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_18211 ] . obo:CHEBI_66924 obo:IAO_0000115 "A monocarboxylic acid anion that is the conjugate base of creatine, obtained by deprotonation of the carboxy group." ; chebi:charge "-1" ; chebi:formula "C4H8N3O2" ; chebi:inchi "InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)/p-1" ; chebi:inchikey "CVSVTCORWBXHQV-UHFFFAOYSA-M" ; chebi:mass "130.12520" ; chebi:monoisotopicmass "130.06220" ; chebi:smiles "CN(CC([O-])=O)C(N)=N" ; oboInOwl:hasExactSynonym "{[imino(amino)methyl](methyl)amino}acetate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(N-methylcarbamimidamido)acetate", "N-[amino(imino)methyl]-N-methylglycinate" ; oboInOwl:id "CHEBI:66924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "creatinate" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_16919 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_57947 ] . obo:CHEBI_66933 obo:IAO_0000115 "Any glycine derivative in which glycine is substituted at position 2 by an alkyl group." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "OC(=O)CN[*]" ; oboInOwl:hasDbXref "MetaCyc:N-Alkylglycine", "PMID:9989229" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-alkylglycines" ; oboInOwl:id "CHEBI:66933" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-alkylglycine" ; rdfs:subClassOf obo:CHEBI_24373, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_66884 ] . obo:CHEBI_66998 obo:IAO_0000115 "A carboxylic acid anion which is a conjugate base of a histidine derivative having either D- or L-configuration." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "histidinate derivatives" ; oboInOwl:id "CHEBI:66998" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "histidinate derivative" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_24599 ] . obo:CHEBI_67011 obo:IAO_0000115 "An N-acyl-L-alpha-amino acid anion obtained by deprotonation of any folic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "folate", "folate anion", "folate anions" ; oboInOwl:id "CHEBI:67011" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "folates" ; rdfs:subClassOf obo:CHEBI_176842, obo:CHEBI_59874, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_37445 ] . obo:CHEBI_67013 obo:IAO_0000115 "Any branched-chain fatty acid anion containing methyl branches only." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "methyl-branched fatty acid anions" ; oboInOwl:id "CHEBI:67013" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methyl-branched fatty acid anion" ; rdfs:subClassOf obo:CHEBI_58955, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_62499 ] . obo:CHEBI_67016 obo:IAO_0000115 "A folate obtained by deprotonation of any tetrahydrofolic acid." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "tetrahydrofolate anion", "tetrahydrofolate anions", "tetrahydrofolates" ; oboInOwl:id "CHEBI:67016" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "tetrahydrofolate" ; rdfs:subClassOf obo:CHEBI_67011, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_26907 ] . obo:CHEBI_67079 obo:IAO_0000115 "Any compound that has anti-inflammatory effects." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-inflammatory agents", "antiinflammatory agent", "antiinflammatory agents" ; oboInOwl:id "CHEBI:67079" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anti-inflammatory agent" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_67142 obo:IAO_0000115 "A molecule that can substitute for a normal nucleobase in nucleic acids." ; oboInOwl:hasDbXref "Wikipedia:Base_analog" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "base analog", "base analogs", "base analogue", "base analogues", "nucleobase analog", "nucleobase analogs", "nucleobase analogues" ; oboInOwl:id "CHEBI:67142" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nucleobase analogue" ; rdfs:subClassOf obo:CHEBI_33832 . obo:CHEBI_67200 obo:IAO_0000115 "A provitamin that can be converted into vitamin A by enzymes from animal tissues." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "provitamin As" ; oboInOwl:id "CHEBI:67200" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "provitamin A" ; rdfs:subClassOf obo:CHEBI_50188 . obo:CHEBI_68452 obo:IAO_0000115 "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." ; oboInOwl:hasDbXref "Wikipedia:Azole" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "azoles" ; oboInOwl:id "CHEBI:68452" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "azole" ; rdfs:subClassOf obo:CHEBI_38101, obo:CHEBI_38179 . obo:CHEBI_68485 obo:IAO_0000115 "alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp with beta-configuration at the reducing end anomeric centre." ; chebi:charge "0" ; chebi:formula "C18H32O16" ; chebi:inchi "InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7+,8+,9-,10-,11-,12-,13-,14-,15+,16-,17-,18+/m1/s1" ; chebi:inchikey "FYGDTMLNYKFZSV-SKWQFERISA-N" ; chebi:mass "504.43710" ; chebi:monoisotopicmass "504.16903" ; chebi:smiles "OC[C@H]1O[C@H](O[C@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O" ; oboInOwl:hasDbXref "GlyGen:G00059MO", "GlyTouCan:G00059MO", "PMID:19443021", "PMID:25568069", "PMID:31537530" ; oboInOwl:hasExactSynonym "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Gala1-4Galb1-4Glcb", "Galalpha1-4Galbeta1-4Glcbeta", "O-alpha-D-galactopyranosyl-(1->4)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose", "WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1", "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose" ; oboInOwl:id "CHEBI:68485" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp" ; rdfs:subClassOf obo:CHEBI_60948, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_53000 ] . obo:CHEBI_68566 obo:IAO_0000115 "An alpha,omega-dicarboxylic acid that is glutaric acid substituted at position 3 by a methyl group." ; chebi:charge "0" ; chebi:formula "C6H10O4" ; chebi:inchi "InChI=1S/C6H10O4/c1-4(2-5(7)8)3-6(9)10/h4H,2-3H2,1H3,(H,7,8)(H,9,10)" ; chebi:inchikey "XJMMNTGIMDZPMU-UHFFFAOYSA-N" ; chebi:mass "146.14120" ; chebi:monoisotopicmass "146.05791" ; chebi:smiles "CC(CC(O)=O)CC(O)=O" ; oboInOwl:hasDbXref "CAS:626-51-7", "HMDB:HMDB0000752", "LIPID_MAPS_instance:LMFA01170117", "PMID:22770225", "Reaxys:1759502" ; oboInOwl:hasExactSynonym "3-methylpentanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-methylglutaric acid" ; oboInOwl:id "CHEBI:68566" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-methylglutaric acid" ; rdfs:subClassOf obo:CHEBI_28383, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17859 ] . obo:CHEBI_68641 obo:IAO_0000115 "An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum." ; chebi:charge "0" ; chebi:formula "C10H12N2O" ; chebi:inchi "InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1" ; chebi:inchikey "UIKROCXWUNQSPJ-VIFPVBQESA-N" ; chebi:mass "176.21510" ; chebi:monoisotopicmass "176.09496" ; chebi:smiles "[H][C@]1(CCC(=O)N1C)c1cccnc1" ; oboInOwl:hasDbXref "CAS:486-56-6", "Drug_Central:737", "HMDB:HMDB0001046", "KNApSAcK:C00034470", "LINCS:LSM-5986", "MetaCyc:CPD-2742", "PMID:14700346", "PMID:21655912", "PMID:21953524", "PMID:22027507", "PMID:22137886", "PMID:22169225", "PMID:22180597", "PMID:22200307", "PMID:22244928", "PMID:22253001", "PMID:22434216", "PMID:22460317", "PMID:22487419", "PMID:22489581", "PMID:22574797", "PMID:22608097", "PMID:22678157", "PMID:22687995", "PMID:22770225", "PMID:22809871", "PMID:22871902", "PMID:22878732", "PMID:22899265", "PMID:22919158", "PMID:23000417", "PMID:23011941", "PMID:23087643", "Reaxys:5736575", "Reaxys:83099", "Wikipedia:Cotinine" ; oboInOwl:hasExactSynonym "(5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-(-)-Cotinine", "(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone", "(S)-Cotinine", "cotinina", "cotinine", "cotininum" ; oboInOwl:id "CHEBI:68641" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(-)-cotinine" ; rdfs:subClassOf obo:CHEBI_26421, obo:CHEBI_26456, obo:CHEBI_46775, obo:CHEBI_74223, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_35469 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_59163 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76967 ] . obo:CHEBI_7044 oboInOwl:hasDbXref "COMe:PRX000322", "KEGG:C05782" ; oboInOwl:hasExactSynonym "Myoglobin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vertebrate myoglobin" ; oboInOwl:id "CHEBI:7044" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "myoglobin" ; rdfs:subClassOf obo:CHEBI_5386 . obo:CHEBI_70709 obo:IAO_0000115 "A hormone agonist that binds to and activates progesterone receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "PR agonist", "PR agonists", "progesterone receptor agonists" ; oboInOwl:id "CHEBI:70709" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "progesterone receptor agonist" ; rdfs:subClassOf obo:CHEBI_51060 . obo:CHEBI_70958 obo:IAO_0000115 "A methylhistidine in which the methyl group is located at N-1." ; chebi:charge "0" ; chebi:formula "C7H11N3O2" ; chebi:inchi "InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)" ; chebi:inchikey "BRMWTNUJHUMWMS-UHFFFAOYSA-N" ; chebi:mass "169.18110" ; chebi:monoisotopicmass "169.08513" ; chebi:smiles "Cn1cnc(CC(N)C(O)=O)c1" ; oboInOwl:hasDbXref "PMID:22770225", "Reaxys:611190" ; oboInOwl:hasExactSynonym "1-methylhistidine", "2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1-methyl-DL-histidine" ; oboInOwl:id "CHEBI:70958" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1-methylhistidine" ; rdfs:subClassOf obo:CHEBI_137682, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84087 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_133608 ] . obo:CHEBI_70959 obo:IAO_0000115 "A methylhistidine in which the methyl group is located at N-3." ; chebi:charge "0" ; chebi:formula "C7H11N3O2" ; chebi:inchi "InChI=1S/C7H11N3O2/c1-10-4-9-3-5(10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)" ; chebi:inchikey "JDHILDINMRGULE-UHFFFAOYSA-N" ; chebi:mass "169.18110" ; chebi:monoisotopicmass "169.08513" ; chebi:smiles "Cn1cncc1CC(N)C(O)=O" ; oboInOwl:hasDbXref "PMID:22770225", "PMID:24009031", "PMID:24681531", "Reaxys:83652" ; oboInOwl:hasExactSynonym "2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid", "3-methylhistidine" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-methyl-DL-histidine" ; oboInOwl:id "CHEBI:70959" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-methylhistidine" ; rdfs:subClassOf obo:CHEBI_137682, obo:CHEBI_83925, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_133609 ] . obo:CHEBI_70979 obo:IAO_0000115 "An N-acylglycine in which the acyl group is specified as isobutryl." ; chebi:charge "0" ; chebi:formula "C6H11NO3" ; chebi:inchi "InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)" ; chebi:inchikey "DCICDMMXFIELDF-UHFFFAOYSA-N" ; chebi:mass "145.15640" ; chebi:monoisotopicmass "145.07389" ; chebi:smiles "CC(C)C(=O)NCC(O)=O" ; oboInOwl:hasDbXref "HMDB:HMDB0000730", "PMID:14723814", "PMID:17712735", "PMID:20528888", "PMID:20836999", "PMID:22770225", "PMID:23062437", "PMID:7360517", "PMID:7408214", "PMID:8548022", "Reaxys:1762789" ; oboInOwl:hasExactSynonym "N-(2-methylpropanoyl)glycine", "[(2-methylpropanoyl)amino]acetic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "N-isobutanoylglycine", "isobutanoylglycine", "isobutyrylglycine" ; oboInOwl:id "CHEBI:70979" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-isobutyrylglycine" ; rdfs:subClassOf obo:CHEBI_16180, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84087 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_133610 ] . obo:CHEBI_71300 obo:IAO_0000115 "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" ; oboInOwl:hasDbXref "Wikipedia:Transferase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 2 inhibitor", "EC 2 inhibitors", "EC 2.* (transferase) inhibitors", "EC 2.* inhibitor", "EC 2.* inhibitors", "transferase inhibitor", "transferase inhibitors" ; oboInOwl:id "CHEBI:71300" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 2.* (transferase) inhibitor" ; rdfs:subClassOf obo:CHEBI_23924 . obo:CHEBI_71406 obo:IAO_0000115 "An organic cation that is the conjugate acid of (R)-adrenaline, obtained by protonation of the amino group; major species at pH 7.3." ; chebi:charge "+1" ; chebi:formula "C9H14NO3" ; chebi:inchi "InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/p+1/t9-/m0/s1" ; chebi:inchikey "UCTWMZQNUQWSLP-VIFPVBQESA-O" ; chebi:mass "184.21240" ; chebi:monoisotopicmass "184.09682" ; chebi:smiles "C[NH2+]C[C@H](O)c1ccc(O)c(O)c1" ; oboInOwl:hasDbXref "MetaCyc:L-EPINEPHRINE" ; oboInOwl:hasExactSynonym "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-N-methylethanaminium" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-adrenaline", "(R)-adrenaline cation", "L-epinephrine cation", "L-epinephrine(1+)" ; oboInOwl:id "CHEBI:71406" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-adrenaline(1+)" ; rdfs:subClassOf obo:CHEBI_25697, obo:CHEBI_35274, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_28918 ] . obo:CHEBI_71666 obo:IAO_0000115 "An amino-acid anion in which the amino group is situated gamma- to the carboxylate group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gamma-amino acid anions" ; oboInOwl:id "CHEBI:71666" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-amino acid anion" ; rdfs:subClassOf obo:CHEBI_37022, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33707 ] . obo:CHEBI_71671 obo:IAO_0000115 "A carbohydrate acid anion obtained by deprotonation of any aldonic acid. Major structure at pH 7.3 of aldonate compounds." ; chebi:charge "-1" ; chebi:formula "(CH2O)n.C2H3O3" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "aldonates" ; oboInOwl:id "CHEBI:71671" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aldonate(1-)" ; rdfs:subClassOf obo:CHEBI_33721, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_22301 ] . obo:CHEBI_72695 obo:IAO_0000115 "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic compound", "organic compounds", "organic molecules" ; oboInOwl:id "CHEBI:72695" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic molecule" ; rdfs:subClassOf obo:CHEBI_25367, obo:CHEBI_50860 . obo:CHEBI_72813 obo:IAO_0000115 "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." ; oboInOwl:hasDbXref "MetaCyc:Exopolysaccharides", "PMID:11160795", "PMID:11785425", "PMID:1444258", "PMID:15738217", "PMID:16075348", "PMID:17440912", "PMID:18097339", "PMID:19453747", "PMID:20172021", "PMID:20631870", "PMID:20718297", "PMID:2688547", "PMID:6354590", "Wikipedia:Exopolysaccharide", "Wikipedia:Extracellular_polymeric_substance" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "exopolysaccharides", "extracellular polymeric substance", "extracellular polymeric substances" ; oboInOwl:id "CHEBI:72813" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "exopolysaccharide" ; rdfs:subClassOf obo:CHEBI_33694 . obo:CHEBI_73336 obo:IAO_0000115 "A drug used in treating and healing of wounds." ; oboInOwl:hasDbXref "Wikipedia:Wound_healing" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "vulneraries", "wound-healing agent", "wound-healing agents", "wound-healing drug", "wound-healing drugs" ; oboInOwl:id "CHEBI:73336" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "vulnerary" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_73398 obo:IAO_0000115 "A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring." ; chebi:charge "0" ; chebi:formula "C8N" ; chebi:mass "110.09230" ; chebi:monoisotopicmass "110.00307" ; chebi:smiles "C1(=C(C(=C2C(=C1*)N(C(=C2*)*)*)*)*)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:73398" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "indole skeleton" ; rdfs:subClassOf obo:CHEBI_73541 . obo:CHEBI_73541 obo:IAO_0000115 "A bicyclic organic group that contains both carbon and hetero atoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "organic heterobicyclic rings" ; oboInOwl:id "CHEBI:73541" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "organic heterobicyclic ring" ; rdfs:subClassOf obo:CHEBI_52845 . obo:CHEBI_73558 obo:IAO_0000115 "A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D3 vitamin", "vitamin D3s" ; oboInOwl:id "CHEBI:73558" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D3 vitamins" ; rdfs:subClassOf obo:CHEBI_27300 . obo:CHEBI_741548 obo:IAO_0000115 "A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group." ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9)" ; chebi:inchikey "UKFXDFUAPNAMPJ-UHFFFAOYSA-N" ; chebi:mass "132.11460" ; chebi:monoisotopicmass "132.04226" ; chebi:smiles "CCC(C(O)=O)C(O)=O" ; oboInOwl:hasDbXref "CAS:516-05-2", "CAS:601-75-2", "HMDB:HMDB0000622", "PMID:20187168", "PMID:22133302", "PMID:23161776", "PMID:6860317", "Reaxys:774334" ; oboInOwl:hasExactSynonym "ethylpropanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,1-propanedicarboxylic acid", "2-ethylmalonic acid", "alpha-carboxybutyric acid" ; oboInOwl:id "CHEBI:741548" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ethylmalonic acid" ; rdfs:subClassOf obo:CHEBI_189840, obo:CHEBI_35692, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30794 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132938 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132939 ] . obo:CHEBI_74222 obo:IAO_0000115 "A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "gamma-lactams" ; oboInOwl:id "CHEBI:74222" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "gamma-lactam" ; rdfs:subClassOf obo:CHEBI_24995 . obo:CHEBI_74223 obo:IAO_0000115 "A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring." ; chebi:charge "0" ; chebi:formula "C4NOR7" ; chebi:mass "78.04890" ; chebi:monoisotopicmass "77.99799" ; chebi:smiles "[*]N1C(=O)C([*])([*])C([*])([*])C1([*])[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-pyrrolidinones", "2-pyrrolidones", "pyrrolidine-2-ones" ; oboInOwl:id "CHEBI:74223" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrrolidin-2-ones" ; rdfs:subClassOf obo:CHEBI_38275, obo:CHEBI_74222 . obo:CHEBI_74337 obo:IAO_0000115 "A D-alpha-amino acid zwitterion that is D-asparagine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C4H8N2O3" ; chebi:inchi "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m1/s1" ; chebi:inchikey "DCXYFEDJOCDNAF-UWTATZPHSA-N" ; chebi:mass "132.11790" ; chebi:monoisotopicmass "132.05349" ; chebi:smiles "NC(=O)C[C@@H]([NH3+])C([O-])=O" ; oboInOwl:hasExactSynonym "(2R)-4-amino-2-azaniumyl-4-oxobutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(2R)-4-amino-2-ammonio-4-oxobutanoate", "D-asparagine" ; oboInOwl:id "CHEBI:74337" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-asparagine zwitterion" ; rdfs:subClassOf obo:CHEBI_59871, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_28159 ] . obo:CHEBI_74345 obo:IAO_0000115 "An imidazolidinone that is imidazolin-2-one substituted at positions 4 and 5 by hydroxy and ureido groups respectively." ; chebi:charge "0" ; chebi:formula "C4H6N4O3" ; chebi:inchi "InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h9H,(H3,5,6,10)(H2,7,8,11)" ; chebi:inchikey "MLVVTNIFHMERMU-UHFFFAOYSA-N" ; chebi:mass "158.11540" ; chebi:monoisotopicmass "158.04399" ; chebi:smiles "NC(=O)Nc1[nH]c(=O)[nH]c1O" ; oboInOwl:hasDbXref "PMID:20826786" ; oboInOwl:hasExactSynonym "1-(5-hydroxy-2-oxo-2,3-dihydro-1H-imidazol-4-yl)urea" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-oxo-4-hydroxy-5-ureidoimidazoline", "allantoin, enol-form" ; oboInOwl:id "CHEBI:74345" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea" ; rdfs:subClassOf obo:CHEBI_47857, obo:CHEBI_55370, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_27612 ], [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_15676 ] . obo:CHEBI_74783 obo:IAO_0000115 "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." ; oboInOwl:hasDbXref "Wikipedia:Astringent" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "adstringent", "adstringents", "astringents" ; oboInOwl:id "CHEBI:74783" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "astringent" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_75325 obo:IAO_0000115 "Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic." ; oboInOwl:hasDbXref "Wikipedia:Cathartic" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "cathartics" ; oboInOwl:id "CHEBI:75325" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "cathartic" ; rdfs:subClassOf obo:CHEBI_52208 . obo:CHEBI_75600 obo:IAO_0000115 "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C--N bond-forming ligase inhibitor", "C--N bond-forming ligase inhibitors", "C-N bond-forming ligase (EC 6.3.*) inhibitor", "C-N bond-forming ligase (EC 6.3.*) inhibitors", "C-N bond-forming ligase inhibitor", "C-N bond-forming ligase inhibitors", "EC 6.3.* (C-N bond-forming ligase) inhibitorS", "EC 6.3.* inhibitor", "EC 6.3.* inhibitors", "EC 6.3.*.* inhibitor", "EC 6.3.*.* inhibitors" ; oboInOwl:id "CHEBI:75600" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.3.* (C-N bond-forming ligase) inhibitor" ; rdfs:subClassOf obo:CHEBI_75603 . obo:CHEBI_75603 obo:IAO_0000115 "Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." ; oboInOwl:hasDbXref "Wikipedia:Ligase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 6.* (ligase) inhibitors", "EC 6.* inhibitor", "EC 6.* inhibitors", "EC 6.*.*.* inhibitor", "EC 6.*.*.* inhibitors", "ligase inhibitor", "ligase inhibitors" ; oboInOwl:id "CHEBI:75603" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.* (ligase) inhibitor" ; rdfs:subClassOf obo:CHEBI_23924 . obo:CHEBI_75604 obo:IAO_0000115 "A ligase inhibitor that interferes with the action of a C-C bond-forming ligase (EC 6.4.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C--C bond-forming ligase inhibitor", "C--C bond-forming ligase inhibitors", "C-C bond-forming ligase (EC 6.4.*) inhibitor", "C-C bond-forming ligase (EC 6.4.*) inhibitorS", "C-C bond-forming ligase inhibitor", "C-C bond-forming ligase inhibitors", "EC 6.4.* (C-C bond-forming ligase) inhibitorS", "EC 6.4.* inhibitor", "EC 6.4.* inhibitors", "EC 6.4.*.* inhibitor", "EC 6.4.*.* inhibitors" ; oboInOwl:id "CHEBI:75604" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.4.* (C-C bond-forming ligase) inhibitor" ; rdfs:subClassOf obo:CHEBI_75603 . obo:CHEBI_75763 obo:IAO_0000115 "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "eukaryotic metabolites" ; oboInOwl:id "CHEBI:75763" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "eukaryotic metabolite" ; rdfs:subClassOf obo:CHEBI_25212 . obo:CHEBI_75767 obo:IAO_0000115 "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." ; oboInOwl:hasAlternativeId "CHEBI:77721", "CHEBI:77743" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "animal metabolites" ; oboInOwl:id "CHEBI:75767" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "animal metabolite" ; rdfs:subClassOf obo:CHEBI_75763 . obo:CHEBI_75768 obo:IAO_0000115 "Any animal metabolite produced during a metabolic reaction in mammals." ; oboInOwl:hasAlternativeId "CHEBI:77464", "CHEBI:77744" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "mammalian metabolites" ; oboInOwl:id "CHEBI:75768" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mammalian metabolite" ; rdfs:subClassOf obo:CHEBI_75767 . obo:CHEBI_75769 obo:IAO_0000115 "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." ; oboInOwl:hasDbXref "MetaCyc:B-vitamins", "PMID:22743781", "PMID:23093174", "PMID:23238962", "PMID:23449527", "PMID:23462586", "PMID:23690582", "Wikipedia:B_vitamin" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "B vitamins", "B-group vitamin", "B-group vitamins", "vitamin B" ; oboInOwl:id "CHEBI:75769" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "B vitamin" ; rdfs:subClassOf obo:CHEBI_35352, obo:CHEBI_36963, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_27314 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50733 ] . obo:CHEBI_75771 obo:IAO_0000115 "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Mus musculus metabolite", "Mus musculus metabolites", "mouse metabolites" ; oboInOwl:id "CHEBI:75771" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "mouse metabolite" ; rdfs:subClassOf obo:CHEBI_75768 . obo:CHEBI_75772 obo:IAO_0000115 "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." ; oboInOwl:hasAlternativeId "CHEBI:76949", "CHEBI:76951" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "S. cerevisiae metabolite", "S. cerevisiae metabolites", "S. cerevisiae secondary metabolite", "S. cerevisiae secondary metabolites", "Saccharomyces cerevisiae metabolites", "Saccharomyces cerevisiae secondary metabolites", "baker's yeast metabolite", "baker's yeast metabolites", "baker's yeast secondary metabolite", "baker's yeast secondary metabolites" ; oboInOwl:id "CHEBI:75772" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Saccharomyces cerevisiae metabolite" ; rdfs:subClassOf obo:CHEBI_76946 . obo:CHEBI_75787 obo:IAO_0000115 "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "prokaryotic metabolites" ; oboInOwl:id "CHEBI:75787" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prokaryotic metabolite" ; rdfs:subClassOf obo:CHEBI_25212 . obo:CHEBI_76042 obo:IAO_0000115 "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "[NH3+]C([*])C([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:Aromatic-Amino-Acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an aromatic amino-acid", "aromatic amino-acid zwitterions" ; oboInOwl:id "CHEBI:76042" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic amino-acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_33856 ] . obo:CHEBI_76206 obo:IAO_0000115 "Any metabolite produced by metabolism of a xenobiotic compound." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "xenobiotic metabolites" ; oboInOwl:id "CHEBI:76206" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "xenobiotic metabolite" ; rdfs:subClassOf obo:CHEBI_25212 . obo:CHEBI_76283 obo:IAO_0000115 "A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of suberic acid; major species at pH 7.3." ; chebi:charge "-2" ; chebi:formula "C10H16O4" ; chebi:inchi "InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)/p-2" ; chebi:inchikey "CXMXRPHRNRROMY-UHFFFAOYSA-L" ; chebi:mass "200.23160" ; chebi:monoisotopicmass "200.10596" ; chebi:smiles "[O-]C(=O)CCCCCCCCC([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:CPD-3623", "PMID:21886157", "Reaxys:3906061" ; oboInOwl:hasExactSynonym "decanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C10-DCA(2-)", "decanedioate", "decanedioate(2-)", "sebacate" ; oboInOwl:id "CHEBI:76283" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "sebacate(2-)" ; rdfs:subClassOf obo:CHEBI_132954, obo:CHEBI_28965, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_76924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_41865 ] . obo:CHEBI_76413 obo:IAO_0000115 "A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'." ; oboInOwl:hasDbXref "Wikipedia:Greenhouse_gas" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "greenhouse gases" ; oboInOwl:id "CHEBI:76413" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "greenhouse gas" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_76414 obo:IAO_0000115 "A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans." ; oboInOwl:hasDbXref "PMID:22519407", "PMID:24001847" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "propellants" ; oboInOwl:id "CHEBI:76414" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "propellant" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_76579 obo:IAO_0000115 "A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)" ; oboInOwl:hasDbXref "LIPID_MAPS_class:LMGL0301" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "triradylglycerols" ; oboInOwl:id "CHEBI:76579" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "triradylglycerol" ; rdfs:subClassOf obo:CHEBI_35741 . obo:CHEBI_76619 obo:IAO_0000115 "A fatty acid anion obtained by deprotonation of the carboxy group of any omega-methyl fatty acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C2H3O2R" ; chebi:mass "59.044" ; chebi:monoisotopicmass "59.01330" ; chebi:smiles "C[*]C([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an omega-methyl fatty acid" ; oboInOwl:id "CHEBI:76619" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "omega-methyl fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868 . obo:CHEBI_76655 obo:IAO_0000115 "A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C1-transferase (EC 2.1.*) inhibitor", "C1-transferase (EC 2.1.*) inhibitors", "C1-transferase inhibitor", "C1-transferase inhibitors", "EC 2.1.* (C1-transferase) inhibitors", "EC 2.1.* inhibitor", "EC 2.1.* inhibitors", "one-carbon-containing group transferase inhibitor", "one-carbon-containing group transferase inhibitors" ; oboInOwl:id "CHEBI:76655" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 2.1.* (C1-transferase) inhibitor" ; rdfs:subClassOf obo:CHEBI_71300 . obo:CHEBI_76725 obo:IAO_0000115 "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." ; oboInOwl:hasDbXref "Wikipedia:Oxidoreductase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 1.* (oxidoreductase) inhibitors", "EC 1.* inhibitor", "EC 1.* inhibitors", "oxidoreductase (EC 1.*) inhibitor", "oxidoreductase (EC 1.*) inhibitors", "oxidoreductase inhibitor", "oxidoreductase inhibitors" ; oboInOwl:id "CHEBI:76725" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 1.* (oxidoreductase) inhibitor" ; rdfs:subClassOf obo:CHEBI_23924 . obo:CHEBI_76726 obo:IAO_0000115 "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors", "EC 1.1.* inhibitor", "EC 1.1.* inhibitors", "inhibitor of oxidoreductase acting on CH-OH group of donor", "inhibitor of oxidoreductase acting on CH-OH group of donors", "inhibitors of oxidoreductase acting on CH-OH group of donor", "inhibitors of oxidoreductase acting on CH-OH group of donors", "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor", "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors", "oxidoreductase acting on donor CH-OH group inhibitor", "oxidoreductase acting on donor CH-OH group inhibitors" ; oboInOwl:id "CHEBI:76726" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor" ; rdfs:subClassOf obo:CHEBI_76725 . obo:CHEBI_76759 obo:IAO_0000115 "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." ; oboInOwl:hasDbXref "Wikipedia:Hydrolase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.* (hydrolase) inhibitors", "EC 3.* inhibitor", "EC 3.* inhibitors", "EC 3.*.*.* inhibitor", "EC 3.*.*.* inhibitors", "hydrolase (EC 3.*) inhibitor", "hydrolase (EC 3.*) inhibitors", "hydrolase inhibitor", "hydrolase inhibitors" ; oboInOwl:id "CHEBI:76759" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.* (hydrolase) inhibitor" ; rdfs:subClassOf obo:CHEBI_23924 . obo:CHEBI_76760 obo:IAO_0000115 "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.1.* (ester hydrolase) inhibitors", "EC 3.1.* inhibitor", "EC 3.1.* inhibitors", "ester hydrolase (EC 3.1.*) inhibitor", "ester hydrolase (EC 3.1.*) inhibitors", "ester hydrolase inhibitor", "ester hydrolase inhibitors" ; oboInOwl:id "CHEBI:76760" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.1.* (ester hydrolase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76759 . obo:CHEBI_76761 obo:IAO_0000115 "A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.2.* (glycosylase) inhibitors", "EC 3.2.* inhibitor", "EC 3.2.* inhibitors", "glycosylase (EC 3.2.*) inhibitor", "glycosylase (EC 3.2.*) inhibitors", "glycosylase inhibitor", "glycosylase inhibitors" ; oboInOwl:id "CHEBI:76761" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.2.* (glycosylase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76759 . obo:CHEBI_76764 obo:IAO_0000115 "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor", "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors", "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor", "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors", "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors", "EC 3.5.* inhibitor", "EC 3.5.* inhibitors" ; oboInOwl:id "CHEBI:76764" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor" ; rdfs:subClassOf obo:CHEBI_76759 . obo:CHEBI_76773 obo:IAO_0000115 "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors", "EC 3.1.1.* inhibitor", "EC 3.1.1.* inhibitors", "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor", "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" ; oboInOwl:id "CHEBI:76773" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.1.1.* (carboxylic ester hydrolase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76760 . obo:CHEBI_76807 obo:IAO_0000115 "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors", "EC 3.5.1.* inhibitor", "EC 3.5.1.* inhibitors", "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor", "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" ; oboInOwl:id "CHEBI:76807" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76764 . obo:CHEBI_76823 obo:IAO_0000115 "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors", "EC 6.3.1.* inhibitor", "EC 6.3.1.* inhibitors", "acid-ammonia (or amine) ligase inhibitor", "acid-ammonia (or amine) ligase inhibitors" ; oboInOwl:id "CHEBI:76823" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor" ; rdfs:subClassOf obo:CHEBI_75600 . obo:CHEBI_76824 obo:IAO_0000115 "An EC 6.4.* (C-C bond-forming ligase) inhibitor that interferes with the action of a carboxylating enzyme (EC 6.4.1.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 6.4.1.* (C-C bond forming ligase) inhibitor", "EC 6.4.1.* (C-C bond forming ligase) inhibitors", "EC 6.4.1.* (C-C bond-forming ligase) inhibitors", "EC 6.4.1.* (carboxylase) inhibitors", "EC 6.4.1.* inhibitor", "EC 6.4.1.* inhibitors", "inhibitor of ligases forming C-C bonds", "inhibitor of ligases forming C-C bonds (EC 6.4.1.*)", "inhibitors of ligases forming C-C bonds", "inhibitors of ligases forming C-C bonds (EC 6.4.1.*)" ; oboInOwl:id "CHEBI:76824" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.4.1.* (carboxylase) inhibitor" ; rdfs:subClassOf obo:CHEBI_75604 . obo:CHEBI_76835 obo:IAO_0000115 "An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors", "EC 1.1.1.* inhibitor", "EC 1.1.1.* inhibitors", "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor", "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors" ; oboInOwl:id "CHEBI:76835" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor" ; rdfs:subClassOf obo:CHEBI_76726 . obo:CHEBI_76874 obo:IAO_0000115 "An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any hydroxymethyl-, formyl- and related transferase (EC 2.1.2.*)." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitors", "EC 2.1.2.* inhibitor", "EC 2.1.2.* inhibitors", "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitor", "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors" ; oboInOwl:id "CHEBI:76874" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor" ; rdfs:subClassOf obo:CHEBI_76655 . obo:CHEBI_76924 obo:IAO_0000115 "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." ; oboInOwl:hasAlternativeId "CHEBI:75766", "CHEBI:76925" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "plant metabolites", "plant secondary metabolites" ; oboInOwl:id "CHEBI:76924" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "plant metabolite" ; rdfs:subClassOf obo:CHEBI_75763 . obo:CHEBI_76928 obo:IAO_0000115 "A fatty acid anion obtained by deprotonation of the carboxy group of any 2,3-saturated fatty acid." ; chebi:charge "-1" ; chebi:formula "C3H4O2R" ; chebi:mass "72.063" ; chebi:monoisotopicmass "72.02113" ; chebi:smiles "[O-]C(=O)CC[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a 2,3-saturated fatty acid" ; oboInOwl:id "CHEBI:76928" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2,3-saturated fatty acid(1-)" ; rdfs:subClassOf obo:CHEBI_28868, obo:CHEBI_83955, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_76929 ] . obo:CHEBI_76929 obo:IAO_0000115 "Any fatty acid in which the first two carbons of the chain attached to the carboxy group are saturated and unbranched." ; chebi:charge "0" ; chebi:formula "C3H5O2R" ; chebi:mass "73.071" ; chebi:monoisotopicmass "73.02895" ; chebi:smiles "OC(=O)CC[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:76929" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2,3-saturated fatty acid" ; rdfs:subClassOf obo:CHEBI_35366, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_76928 ] . obo:CHEBI_76932 obo:IAO_0000115 "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "metabolic pathway inhibitor", "metabolic pathway inhibitors", "pathway inhibitors" ; oboInOwl:id "CHEBI:76932" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pathway inhibitor" ; rdfs:subClassOf obo:CHEBI_23924 . obo:CHEBI_76946 obo:IAO_0000115 "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." ; oboInOwl:hasAlternativeId "CHEBI:75765", "CHEBI:76947" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fungal metabolites" ; oboInOwl:id "CHEBI:76946" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fungal metabolite" ; rdfs:subClassOf obo:CHEBI_75763 . obo:CHEBI_76956 obo:IAO_0000115 "Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus." ; oboInOwl:hasAlternativeId "CHEBI:75864", "CHEBI:76958" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Aspergillus metabolites" ; oboInOwl:id "CHEBI:76956" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Aspergillus metabolite" ; rdfs:subClassOf obo:CHEBI_76946 . obo:CHEBI_76967 obo:IAO_0000115 "Any human metabolite produced by metabolism of a xenobiotic compound in humans." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "human xenobiotic metabolites" ; oboInOwl:id "CHEBI:76967" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "human xenobiotic metabolite" ; rdfs:subClassOf obo:CHEBI_76206, obo:CHEBI_77746 . obo:CHEBI_76969 obo:IAO_0000115 "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." ; oboInOwl:hasAlternativeId "CHEBI:75760", "CHEBI:76970" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:76969" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "bacterial metabolite" ; rdfs:subClassOf obo:CHEBI_75787 . obo:CHEBI_76971 obo:IAO_0000115 "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "E.coli metabolite", "E.coli metabolites", "Escherichia coli metabolites" ; oboInOwl:id "CHEBI:76971" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Escherichia coli metabolite" ; rdfs:subClassOf obo:CHEBI_76969 . obo:CHEBI_77119 obo:IAO_0000115 "An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-E2 9-reductase (EC 1.1.1.189)." ; oboInOwl:hasDbXref "Wikipedia:Prostaglandin-E2_9-reductase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitor", "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors", "9-keto-prostaglandin E2 reductase inhibitor", "9-keto-prostaglandin E2 reductase inhibitors", "9-ketoprostaglandin reductase inhibitor", "9-ketoprostaglandin reductase inhibitors", "EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitors", "EC 1.1.1.189 inhibitor", "EC 1.1.1.189 inhibitors", "PGE-9-ketoreductase inhibitor", "PGE-9-ketoreductase inhibitors", "PGE2 9-oxoreductase inhibitor", "PGE2 9-oxoreductase inhibitors", "PGE2-9-OR inhibitor", "PGE2-9-OR inhibitors", "PGE2-9-ketoreductase inhibitor", "PGE2-9-ketoreductase inhibitors", "prostaglandin 9-ketoreductase inhibitor", "prostaglandin 9-ketoreductase inhibitors", "prostaglandin E 9-ketoreductase inhibitor", "prostaglandin E 9-ketoreductase inhibitors", "prostaglandin E2-9-oxoreductase inhibitor", "prostaglandin E2-9-oxoreductase inhibitors", "prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitor", "prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitors", "reductase, 15-hydroxy-9-oxoprostaglandin inhibitor", "reductase, 15-hydroxy-9-oxoprostaglandin inhibitors" ; oboInOwl:id "CHEBI:77119" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76835 . obo:CHEBI_77182 obo:IAO_0000115 "A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199)." ; oboInOwl:hasDbXref "Wikipedia:Food_coloring" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food coloring", "food colorings", "food colourings" ; oboInOwl:id "CHEBI:77182" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food colouring" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_77450 obo:IAO_0000115 "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any dicarboxylic acid monoamide; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C2H2NO3R" ; chebi:mass "88.042" ; chebi:monoisotopicmass "88.00347" ; chebi:smiles "NC(=O)[*]C([O-])=O" ; oboInOwl:hasDbXref "MetaCyc:DICARBOXYLIC-ACID-MONOAMIDES" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a monoamide of a dicarboxylate" ; oboInOwl:id "CHEBI:77450" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dicarboxylic acid monoamide(1-)" ; rdfs:subClassOf obo:CHEBI_35757, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35735 ] . obo:CHEBI_77746 obo:IAO_0000115 "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." ; oboInOwl:hasAlternativeId "CHEBI:75770", "CHEBI:77123" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "H. sapiens metabolite", "H. sapiens metabolites", "Homo sapiens metabolite", "Homo sapiens metabolites" ; oboInOwl:id "CHEBI:77746" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "human metabolite" ; rdfs:subClassOf obo:CHEBI_75768 . obo:CHEBI_77941 obo:IAO_0000115 "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." ; oboInOwl:hasDbXref "Wikipedia:Amidase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 3.5.1.4 (amidase) inhibitors", "EC 3.5.1.4 inhibitor", "EC 3.5.1.4 inhibitors", "N-acetylaminohydrolase inhibitor", "N-acetylaminohydrolase inhibitors", "acylamidase inhibitor", "acylamidase inhibitors", "acylamide amidohydrolase inhibitor", "acylamide amidohydrolase inhibitors", "amidase (EC 3.5.1.4) inhibitor", "amidase (EC 3.5.1.4) inhibitors", "amidase inhibitor", "amidase inhibitors", "amidohydrolase inhibitor", "amidohydrolase inhibitors", "deaminase inhibitor", "deaminase inhibitors", "fatty acylamidase inhibitor", "fatty acylamidase inhibitors" ; oboInOwl:id "CHEBI:77941" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.5.1.4 (amidase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76807 . obo:CHEBI_77968 obo:IAO_0000115 "A compound that is used to keep a substance moist." ; oboInOwl:hasDbXref "Wikipedia:humectant" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "humectants" ; oboInOwl:id "CHEBI:77968" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "humectant" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_77969 obo:IAO_0000115 "A humectant that is used as a food additive to prevent foodstuffs from drying out." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food humectants" ; oboInOwl:id "CHEBI:77969" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food humectant" ; rdfs:subClassOf obo:CHEBI_64047, obo:CHEBI_77968 . obo:CHEBI_77974 obo:IAO_0000115 "A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container." ; oboInOwl:hasDbXref "Wikipedia:Packaging_gas" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food packaging gases" ; oboInOwl:id "CHEBI:77974" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food packaging gas" ; rdfs:subClassOf obo:CHEBI_64047 . obo:CHEBI_78017 obo:IAO_0000115 "A propellant that is used to expel foods from an aerosol container." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "food propellants" ; oboInOwl:id "CHEBI:78017" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food propellant" ; rdfs:subClassOf obo:CHEBI_64047, obo:CHEBI_76414 . obo:CHEBI_78113 obo:IAO_0000115 "Any saturated fatty acid anion containing 3 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C3H5O2" ; chebi:mass "73.07060" ; chebi:monoisotopicmass "73.02895" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 3:0" ; oboInOwl:id "CHEBI:78113" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 3:0" ; rdfs:subClassOf obo:CHEBI_58951, obo:CHEBI_58953 . obo:CHEBI_78115 obo:IAO_0000115 "Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C4H7O2" ; chebi:mass "87.09718" ; chebi:monoisotopicmass "87.04460" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 4:0" ; oboInOwl:id "CHEBI:78115" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 4:0" ; rdfs:subClassOf obo:CHEBI_58951, obo:CHEBI_58953, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_140601 ] . obo:CHEBI_78116 obo:IAO_0000115 "Any saturated fatty acid anion containing 6 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C6H11O2" ; chebi:mass "115.15034" ; chebi:monoisotopicmass "115.07590" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 6:0" ; oboInOwl:id "CHEBI:78116" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 6:0" ; rdfs:subClassOf obo:CHEBI_58953, obo:CHEBI_59558 . obo:CHEBI_78121 obo:IAO_0000115 "Any saturated fatty acid anion containing 14 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C14H27O2" ; chebi:mass "227.36298" ; chebi:monoisotopicmass "227.20111" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 14:0" ; oboInOwl:id "CHEBI:78121" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 14:0" ; rdfs:subClassOf obo:CHEBI_58953 . obo:CHEBI_78123 obo:IAO_0000115 "Any saturated fatty acid anion containing 16 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C16H31O2" ; chebi:mass "255.41610" ; chebi:monoisotopicmass "255.23241" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 16:0" ; oboInOwl:id "CHEBI:78123" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 16:0" ; rdfs:subClassOf obo:CHEBI_58953 . obo:CHEBI_78125 obo:IAO_0000115 "Any saturated fatty acid anion containing 18 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C18H35O2" ; chebi:mass "283.46930" ; chebi:monoisotopicmass "283.26371" ; chebi:smiles "[O-]C([*])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "fatty acid 18:0" ; oboInOwl:id "CHEBI:78125" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fatty acid anion 18:0" ; rdfs:subClassOf obo:CHEBI_58953 . obo:CHEBI_78295 obo:IAO_0000115 "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "dietary component", "dietary components", "food components" ; oboInOwl:id "CHEBI:78295" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "food component" ; rdfs:subClassOf obo:CHEBI_52211 . obo:CHEBI_78298 obo:IAO_0000115 "Any minor or unwanted substance introduced into the environment that can have undesired effects." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "environmental contaminants" ; oboInOwl:id "CHEBI:78298" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "environmental contaminant" ; rdfs:subClassOf obo:CHEBI_51086 . obo:CHEBI_78320 obo:IAO_0000115 "A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group." ; chebi:charge "0" ; chebi:formula "C3H6O3" ; chebi:inchi "InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)" ; chebi:inchikey "JVTAAEKCZFNVCJ-UHFFFAOYSA-N" ; chebi:mass "90.07790" ; chebi:monoisotopicmass "90.03169" ; chebi:smiles "CC(O)C(O)=O" ; oboInOwl:hasDbXref "CAS:50-21-5", "KEGG:C01432", "KEGG:D00111" ; oboInOwl:hasExactSynonym "2-Hydroxypropanoic acid", "2-hydroxypropanoic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2-Hydroxypropionic acid", "Lactic acid" ; oboInOwl:id "CHEBI:78320" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-hydroxypropanoic acid" ; rdfs:subClassOf obo:CHEBI_49302, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_83056 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_84735 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_30768 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_24996 ] . obo:CHEBI_78433 obo:IAO_0000115 "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." ; oboInOwl:hasDbXref "Wikipedia:Refrigerant" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "refrigerants" ; oboInOwl:id "CHEBI:78433" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "refrigerant" ; rdfs:subClassOf obo:CHEBI_33232 . obo:CHEBI_78444 obo:IAO_0000115 "Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 )." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Alpha-carboxylesterase inhibitor", "Alpha-carboxylesterase inhibitors", "Beta-esterase inhibitor", "Beta-esterase inhibitors", "EC 3.1.1.1 (carboxylesterase) inhibitors", "ali-esterase inhibitor", "ali-esterase inhibitors", "butyrate esterase inhibitor", "butyrate esterase inhibitors", "butyryl esterase inhibitor", "butyryl esterase inhibitors", "carboxyl ester hydrolase inhibitor", "carboxyl ester hydrolase inhibitors", "carboxylate esterase inhibitor", "carboxylate esterase inhibitors", "carboxylesterase inhibitor", "carboxylesterase inhibitors", "carboxylic acid esterase inhibitor", "carboxylic acid esterase inhibitors", "carboxylic esterase inhibitor", "carboxylic esterase inhibitors", "carboxylic-ester hydrolase inhibitor", "carboxylic-ester hydrolase inhibitors", "cocaine esterase inhibitor", "cocaine esterase inhibitors", "esterase A inhibitor", "esterase A inhibitors", "esterase B inhibitor", "esterase B inhibitors", "esterase D inhibitor", "esterase D inhibitors", "methylbutyrase inhibitor", "methylbutyrase inhibitors", "methylbutyrate esterase inhibitor", "methylbutyrate esterase inhibitors", "monobutyrase inhibitor", "monobutyrase inhibitors", "nonspecific carboxylesterase inhibitor", "nonspecific carboxylesterase inhibitors", "procaine esterase inhibitor", "procaine esterase inhibitors", "propionyl esterase inhibitor", "propionyl esterase inhibitors", "serine esterase inhibitor", "serine esterase inhibitors", "triacetin esterase inhibitor", "triacetin esterase inhibitors", "vitamin A esterase inhibitor", "vitamin A esterase inhibitors" ; oboInOwl:id "CHEBI:78444" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 3.1.1.1 (carboxylesterase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76773 . obo:CHEBI_78574 obo:IAO_0000115 "Any pyrimidine that bears one or more carboxylic acid substituents." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "pyrimidinecarboxylic acids" ; oboInOwl:id "CHEBI:78574" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pyrimidinecarboxylic acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_39447 . obo:CHEBI_78608 obo:IAO_0000115 "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." ; chebi:charge "0" ; chebi:formula "C2H4NO2R" ; chebi:mass "74.059" ; chebi:monoisotopicmass "74.02420" ; chebi:smiles "[NH3+]C([*])C([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:83409" ; oboInOwl:hasDbXref "MetaCyc:Alpha-Amino-Acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an alpha-amino acid" ; oboInOwl:id "CHEBI:78608" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-amino acid zwitterion" ; rdfs:subClassOf obo:CHEBI_35238, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_33704 ] . obo:CHEBI_78616 obo:IAO_0000115 "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "carbohydrates and derivatives", "carbohydrates and their derivatives" ; oboInOwl:id "CHEBI:78616" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "carbohydrates and carbohydrate derivatives" ; rdfs:subClassOf obo:CHEBI_36963 . obo:CHEBI_78631 obo:IAO_0000115 "A chromanol that is chromane in which the hydrogen at position 6 is replaced by a hydroxy group." ; chebi:charge "0" ; chebi:formula "C9H10O2" ; chebi:inchi "InChI=1S/C9H10O2/c10-8-3-4-9-7(6-8)2-1-5-11-9/h3-4,6,10H,1-2,5H2" ; chebi:inchikey "GZCJJOLJSBCUNR-UHFFFAOYSA-N" ; chebi:mass "150.17450" ; chebi:monoisotopicmass "150.06808" ; chebi:smiles "Oc1ccc2OCCCc2c1" ; oboInOwl:hasDbXref "Reaxys:1283166" ; oboInOwl:hasExactSynonym "3,4-dihydro-2H-chromen-6-ol" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3,4-dihydrobenzopyran-6-ol" ; oboInOwl:id "CHEBI:78631" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "chroman-6-ol" ; rdfs:subClassOf obo:CHEBI_23229, obo:CHEBI_33853, [ a owl:Restriction ; owl:onProperty chebi1:has_parent_hydride ; owl:someValuesFrom obo:CHEBI_33224 ] . obo:CHEBI_78675 obo:IAO_0000115 "Any metabolite produced by all living cells." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "essential metabolite", "essential metabolites", "fundamental metabolites" ; oboInOwl:id "CHEBI:78675" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "fundamental metabolite" ; rdfs:subClassOf obo:CHEBI_25212 . obo:CHEBI_78803 obo:IAO_0000115 "An animal metabolite produced by any member of the phylum Nematoda." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "nematode metabolites" ; oboInOwl:id "CHEBI:78803" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "nematode metabolite" ; rdfs:subClassOf obo:CHEBI_75767 . obo:CHEBI_78804 obo:IAO_0000115 "A nematode metabolite produced by Caenorhabditis elegans." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "C. elegans metabolite", "C. elegans metabolites", "Caenorhabditis elegans metabolites" ; oboInOwl:id "CHEBI:78804" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Caenorhabditis elegans metabolite" ; rdfs:subClassOf obo:CHEBI_78803 . obo:CHEBI_78840 obo:IAO_0000115 "Any organic molecular entity that contains at least one C=C bond." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "olefinic compounds" ; oboInOwl:id "CHEBI:78840" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "olefinic compound" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_78954 obo:IAO_0000115 "A hydroxy fatty acid that is a straight-chain fatty acid in which one of the hydrogens attached to the carbon adjacent to the terminal methyl group (i.e. at the (omega-1) position) is replaced by a hydroxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(omega-1)-hydroxy fatty acids" ; oboInOwl:id "CHEBI:78954" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(omega-1)-hydroxy fatty acid" ; rdfs:subClassOf obo:CHEBI_24654, obo:CHEBI_35681, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_84497 ] . obo:CHEBI_7896 obo:IAO_0000115 "A long-chain fatty acid anion that is the conjugate base of hexadecanoic acid (palmitic acid); major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C16H31O2" ; chebi:inchi "InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1" ; chebi:inchikey "IPCSVZSSVZVIGE-UHFFFAOYSA-M" ; chebi:mass "255.41610" ; chebi:monoisotopicmass "255.23295" ; chebi:smiles "CCCCCCCCCCCCCCCC([O-])=O" ; oboInOwl:hasAlternativeId "CHEBI:231736" ; oboInOwl:hasDbXref "Beilstein:3589907", "CAS:143-20-4", "Gmelin:344266", "HMDB:HMDB0000220", "MetaCyc:PALMITATE", "Reaxys:3589907" ; oboInOwl:hasExactSynonym "hexadecanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(16:0)", "1-hexyldecanoate", "1-pentadecanecarboxylate", "CH3-[CH2]14-COO(-)", "Hexadecanoic acid, ion(1-)", "n-hexadecanoate", "n-hexadecoate", "palmitate", "pentadecanecarboxylate" ; oboInOwl:id "CHEBI:7896" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hexadecanoate" ; rdfs:subClassOf obo:CHEBI_57560, obo:CHEBI_76619, obo:CHEBI_78123, obo:CHEBI_83955, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75772 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_15756 ] . obo:CHEBI_79020 obo:IAO_0000115 "A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "2,3-unsaturated monocarboxylic acid", "2,3-unsaturated monocarboxylic acids", "alpha,beta-unsaturated monocarboxylic acids" ; oboInOwl:id "CHEBI:79020" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha,beta-unsaturated monocarboxylic acid" ; rdfs:subClassOf obo:CHEBI_25384 . obo:CHEBI_79026 obo:IAO_0000115 "An organic anionic group derived from molybdenum cofactor(3-). It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." ; chebi:charge "-3" ; chebi:formula "C10H10MoN5O8PS3" ; chebi:mass "551.33000" ; chebi:monoisotopicmass "552.84832" ; chebi:smiles "Nc1nc2N[C@@H]3O[C@H](COP([O-])([O-])=O)C4=C(S[Mo]([O-])(=O)(S-*)S4)[C@@H]3Nc2c(=O)[nH]1" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "molybdenum cofactor" ; oboInOwl:id "CHEBI:79026" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "molybdenum cofactor(3-)" ; rdfs:subClassOf obo:CHEBI_64775, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_60525 ] . obo:CHEBI_79209 obo:IAO_0000115 "A sialodiaosylceramide consisting of the trisaccharide alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose attached to the primary hydroxy function of a ceramide with undefined sphingoid base." ; chebi:charge "0" ; chebi:formula "C27H44N2O21R2" ; chebi:mass "732.640" ; chebi:monoisotopicmass "732.24366" ; chebi:smiles "CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](OC[C@H](NC([*])=O)[C@H](O)[*])O[C@@H]3CO)[C@@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O" ; oboInOwl:hasDbXref "PMID:1601877", "PMID:8643456" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ganglioside GM3" ; oboInOwl:id "CHEBI:79209" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide" ; rdfs:subClassOf obo:CHEBI_36544, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_79210 ] . obo:CHEBI_79210 obo:IAO_0000115 "An anionic ganglioside that is the conjugate base of alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C27H43N2O21R2" ; chebi:mass "731.632" ; chebi:monoisotopicmass "731.23583" ; chebi:smiles "CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](OC[C@H](NC([*])=O)[C@H](O)[*])O[C@@H]3CO)[C@@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C([O-])=O" ; oboInOwl:hasDbXref "PMID:1601877", "PMID:8643456" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ganglioside GM3", "ganglioside GM3(1-)" ; oboInOwl:id "CHEBI:79210" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(1-)" ; rdfs:subClassOf obo:CHEBI_79346, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_79209 ] . obo:CHEBI_79346 obo:IAO_0000115 "Any carbohydrate acid derivative anion obtained by deprotonation of at least one of the neuraminosyl carboxy groups of a ganglioside." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ganglioside anion" ; oboInOwl:id "CHEBI:79346" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "anionic ganglioside" ; rdfs:subClassOf obo:CHEBI_63551 . obo:CHEBI_79387 obo:IAO_0000115 "Any inorganic anion with a valency of three." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "trivalent inorganic anions" ; oboInOwl:id "CHEBI:79387" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "trivalent inorganic anion" ; rdfs:subClassOf obo:CHEBI_24834 . obo:CHEBI_79388 obo:IAO_0000115 "Any inorganic anion with a valency of two." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "divalent inorganic anions" ; oboInOwl:id "CHEBI:79388" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "divalent inorganic anion" ; rdfs:subClassOf obo:CHEBI_24834 . obo:CHEBI_79389 obo:IAO_0000115 "Any inorganic anion with a valency of one." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "monovalent inorganic anions" ; oboInOwl:id "CHEBI:79389" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monovalent inorganic anion" ; rdfs:subClassOf obo:CHEBI_24834 . obo:CHEBI_81568 oboInOwl:hasDbXref "CAS:9002-67-9", "KEGG:C18183" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "ICSH", "Interstitial cell stimulating hormone", "LH" ; oboInOwl:id "CHEBI:81568" ; oboInOwl:inSubset chebi3:_STAR ; a owl:Class ; rdfs:label "Luteinizing hormone" ; rdfs:subClassOf obo:CHEBI_50860 . obo:CHEBI_82663 obo:IAO_0000115 "An elemental molecular entity in which all of the atoms have atomic number 26." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:82663" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "elemental iron" ; rdfs:subClassOf obo:CHEBI_24873, obo:CHEBI_33259 . obo:CHEBI_83038 obo:IAO_0000115 "A Daphnia metabolite produced by the species Daphnia galeata." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Daphnia galeata metabolites" ; oboInOwl:id "CHEBI:83038" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Daphnia galeata metabolite" ; rdfs:subClassOf obo:CHEBI_83057 . obo:CHEBI_83039 obo:IAO_0000115 "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "crustacean metabolites" ; oboInOwl:id "CHEBI:83039" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "crustacean metabolite" ; rdfs:subClassOf obo:CHEBI_75767 . obo:CHEBI_83056 obo:IAO_0000115 "A Daphnia metabolite produced by the species Daphnia magna." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Daphnia magna metabolites" ; oboInOwl:id "CHEBI:83056" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Daphnia magna metabolite" ; rdfs:subClassOf obo:CHEBI_83057 . obo:CHEBI_83057 obo:IAO_0000115 "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" ; oboInOwl:hasDbXref "Wikipedia:Daphnia" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Daphnia metabolites" ; oboInOwl:id "CHEBI:83057" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "Daphnia metabolite" ; rdfs:subClassOf obo:CHEBI_83039 . obo:CHEBI_83563 obo:IAO_0000115 "Any alkane having a chain length of at least 13 carbon atoms." ; chebi:charge "0" ; chebi:formula "HR" ; chebi:mass "1.008" ; chebi:monoisotopicmass "1.00783" ; chebi:smiles "*[H]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a long-chain alkane" ; oboInOwl:id "CHEBI:83563" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "long-chain alkane" ; rdfs:subClassOf obo:CHEBI_18310 . obo:CHEBI_83811 obo:IAO_0000115 "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "canonical amino acid derivative", "canonical amino acid derivatives", "canonical amino-acid derivative", "canonical amino-acid derivatives", "proteinogenic amino acid derivatives", "proteinogenic amino-acid derivative", "proteinogenic amino-acid derivatives" ; oboInOwl:id "CHEBI:83811" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proteinogenic amino acid derivative" ; rdfs:subClassOf obo:CHEBI_83821, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_83813 ] . obo:CHEBI_83812 obo:IAO_0000115 "Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "non-canonical amino acid derivative", "non-canonical amino-acid derivatives", "non-proteinogenic amino-acid derivatives" ; oboInOwl:id "CHEBI:83812" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "non-proteinogenic amino acid derivative" ; rdfs:subClassOf obo:CHEBI_83821 . obo:CHEBI_83813 obo:IAO_0000115 "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." ; oboInOwl:hasDbXref "Wikipedia:Proteinogenic_amino_acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "canonical amino acid", "canonical amino acids", "proteinogenic amino acids" ; oboInOwl:id "CHEBI:83813" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "proteinogenic amino acid" ; rdfs:subClassOf obo:CHEBI_33575, obo:CHEBI_35352 . obo:CHEBI_83820 obo:IAO_0000115 "Any amino-acid that is not naturally encoded in the genetic code of any organism." ; oboInOwl:hasDbXref "Wikipedia:Non-proteinogenic_amino_acids" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "non-canonical amino acid", "non-canonical amino acids", "non-canonical amino-acid", "non-canonical amino-acids", "non-coded amino acid", "non-coded amino acids", "non-coded amino-acid", "non-coded amino-acids", "non-proteinogenic amino acids", "non-proteinogenic amino-acid", "non-proteinogenic amino-acids" ; oboInOwl:id "CHEBI:83820" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "non-proteinogenic amino acid" ; rdfs:subClassOf obo:CHEBI_33709 . obo:CHEBI_83821 obo:IAO_0000115 "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." ; oboInOwl:hasAlternativeId "CHEBI:25359" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "amino acid derivatives", "modified amino acids" ; oboInOwl:id "CHEBI:83821" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "amino acid derivative" ; rdfs:subClassOf obo:CHEBI_35352 . obo:CHEBI_83822 obo:IAO_0000115 "Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "non-proteinogenic L-alpha-amino acids" ; oboInOwl:id "CHEBI:83822" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "non-proteinogenic L-alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_15705, obo:CHEBI_83925 . obo:CHEBI_8386 chebi:charge "0" ; chebi:formula "C21H36" ; chebi:inchi "InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3/t15-,16?,17-,18-,19-,20-,21+/m0/s1" ; chebi:inchikey "JWMFYGXQPXQEEM-WZBAXQLOSA-N" ; chebi:mass "288.51054" ; chebi:monoisotopicmass "288.28170" ; chebi:smiles "[H][C@]1(CC)CC[C@@]2([H])[C@]3([H])CCC4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C" ; oboInOwl:hasDbXref "LIPID_MAPS_instance:LMST02030000", "Wikipedia:Pregnane" ; oboInOwl:hasExactSynonym "pregnane" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:8386" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "pregnane" ; rdfs:subClassOf obo:CHEBI_35508 . obo:CHEBI_83925 obo:IAO_0000115 "Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "non-proteinogenic alpha-amino acids", "non-proteinogenic alpha-amino-acid", "non-proteinogenic alpha-amino-acids" ; oboInOwl:id "CHEBI:83925" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "non-proteinogenic alpha-amino acid" ; rdfs:subClassOf obo:CHEBI_33704, obo:CHEBI_83820 . obo:CHEBI_83955 obo:IAO_0000115 "A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid." ; chebi:charge "-1" ; chebi:formula "C2H2O2R" ; chebi:mass "58.036" ; chebi:monoisotopicmass "58.00548" ; chebi:smiles "[O-]C(=O)C[*]" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "1,2-saturated fatty acid anion", "a 1,2-saturated fatty acid" ; oboInOwl:id "CHEBI:83955" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-saturated fatty acid anion" ; rdfs:subClassOf obo:CHEBI_28868 . obo:CHEBI_83972 obo:IAO_0000115 "A methyl-branched fatty acid anion obtained by deprotonation of the carboxy group of any 3-methyl fatty acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C4H6O2R" ; chebi:mass "86.089" ; chebi:monoisotopicmass "86.03678" ; chebi:smiles "CC([*])CC([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "3-methyl fatty acid", "3-methyl-branched fatty acid anion", "3-methyl-branched fatty acid(1-)" ; oboInOwl:id "CHEBI:83972" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-methyl fatty acid anion" ; rdfs:subClassOf obo:CHEBI_67013 . obo:CHEBI_83982 obo:IAO_0000115 "A proteinogenic amino acid derivative resulting from reaction of L-glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of L-glutamic acid by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-glutamic acid derivatives" ; oboInOwl:id "CHEBI:83982" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-glutamic acid derivative" ; rdfs:subClassOf obo:CHEBI_24315, obo:CHEBI_83811, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16015 ] . obo:CHEBI_84087 obo:IAO_0000115 "Any metabolite (endogenous or exogenous) found in human urine samples." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "human urinary metabolites" ; oboInOwl:id "CHEBI:84087" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "human urinary metabolite" ; rdfs:subClassOf obo:CHEBI_77746 . obo:CHEBI_84118 obo:IAO_0000115 "A sialodiaosylceramide that is an alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on nitrogen is (15Z)-tetracos-15-enoyl." ; chebi:charge "0" ; chebi:formula "C65H118N2O21" ; chebi:inchi "InChI=1S/C65H118N2O21/c1-4-6-8-10-12-14-16-18-19-20-21-22-23-24-25-27-29-31-33-35-37-39-52(75)67-46(47(72)38-36-34-32-30-28-26-17-15-13-11-9-7-5-2)44-83-62-57(79)56(78)59(51(43-70)85-62)86-63-58(80)61(55(77)50(42-69)84-63)88-65(64(81)82)40-48(73)53(66-45(3)71)60(87-65)54(76)49(74)41-68/h18-19,36,38,46-51,53-63,68-70,72-74,76-80H,4-17,20-35,37,39-44H2,1-3H3,(H,66,71)(H,67,75)(H,81,82)/b19-18-,38-36+/t46-,47+,48-,49+,50+,51+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63-,65-/m0/s1" ; chebi:inchikey "PFJKOHUKELZMLE-VEUXDRLPSA-N" ; chebi:mass "1263.63320" ; chebi:monoisotopicmass "1262.82271" ; chebi:smiles "CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCC\\C=C/CCCCCCCC" ; oboInOwl:hasDbXref "PMID:24362891" ; oboInOwl:hasExactSynonym "(2S,3R,4E)-3-hydroxy-2-[(15Z)-tetracos-15-enoylamino]octadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "G(M3) ganglioside", "GM3", "NANA-Gal-Glc-ceramide", "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-(15Z)-tetracos-15-enoylsphingosine", "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-cis-tetracos-15-enoylsphingosine", "monosialodihexosylganglioside", "monosialoganglioside GM3" ; oboInOwl:id "CHEBI:84118" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "ganglioside GM3" ; rdfs:subClassOf obo:CHEBI_15681, obo:CHEBI_36544 . obo:CHEBI_84125 obo:IAO_0000115 "A glycotetraosylceramide in which a linear beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->-4)-beta-D-Gal-(1->4)-beta-D-Glc tetrasaccharide unit is linked glycosidically to a (3R,4E)-3-hydroxy-2-(pentacosanoylamino)octadec-4-en-1-yl ceramide group." ; chebi:charge "0" ; chebi:formula "C68H124N2O23" ; chebi:inchi "InChI=1S/C68H124N2O23/c1-4-6-8-10-12-14-16-18-19-20-21-22-23-24-25-27-29-31-33-35-37-39-52(77)70-46(47(76)38-36-34-32-30-28-26-17-15-13-11-9-7-5-2)44-86-66-59(83)57(81)62(50(42-73)89-66)91-67-60(84)58(82)63(51(43-74)90-67)92-68-61(85)64(55(79)49(41-72)88-68)93-65-53(69-45(3)75)56(80)54(78)48(40-71)87-65/h18-19,36,38,46-51,53-68,71-74,76,78-85H,4-17,20-35,37,39-44H2,1-3H3,(H,69,75)(H,70,77)/b19-18-,38-36+/t46-,47+,48+,49+,50+,51+,53+,54-,55-,56+,57+,58+,59+,60+,61+,62+,63-,64-,65-,66+,67-,68+/m0/s1" ; chebi:inchikey "WSOCRZVLWFROQD-NCMUZYOHSA-N" ; chebi:mass "1337.71180" ; chebi:monoisotopicmass "1336.85949" ; chebi:smiles "CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)NC(=O)CCCCCCCCCCCCC\\C=C/CCCCCCCC" ; oboInOwl:hasDbXref "PMID:24362891" ; oboInOwl:hasExactSynonym "(15Z)-N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(15Z)-N-[(2S,3R,4E)-1-{[N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide", "GalbetaNAcbeta3Galalpha4Galbeta4GlcbetaCer", "globoside Gb4Cer(d18:1(4E)/24:1(15Z))" ; oboInOwl:id "CHEBI:84125" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "globoside Gb4" ; rdfs:subClassOf obo:CHEBI_18259, obo:CHEBI_23075 . obo:CHEBI_84185 obo:IAO_0000115 "A non-proteinogenic amino acid derivative resulting from reaction of D-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of D-proline by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "D-proline derivatives" ; oboInOwl:id "CHEBI:84185" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "D-proline derivative" ; rdfs:subClassOf obo:CHEBI_26273, obo:CHEBI_83812, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_16313 ] . obo:CHEBI_84186 obo:IAO_0000115 "A proteinogenic amino acid derivative resulting from reaction of L-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of L-proline by a heteroatom." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "L-proline derivatives" ; oboInOwl:id "CHEBI:84186" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "L-proline derivative" ; rdfs:subClassOf obo:CHEBI_26273, obo:CHEBI_83811, [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_17203 ] . obo:CHEBI_84196 obo:IAO_0000115 "A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any 3-hydroxy fatty acid." ; chebi:charge "-1" ; chebi:formula "C3H4O3R" ; chebi:mass "88.062" ; chebi:monoisotopicmass "88.01604" ; chebi:smiles "OC([*])CC([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a 3-hydroxy fatty acid" ; oboInOwl:id "CHEBI:84196" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "3-hydroxy fatty acid anion" ; rdfs:subClassOf obo:CHEBI_59835, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_59845 ] . obo:CHEBI_84497 obo:IAO_0000115 "A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any (omega-1)-hydroxy fatty acid; major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "C3H5O3R" ; chebi:mass "89.070" ; chebi:monoisotopicmass "89.02387" ; chebi:smiles "CC(O)[*]C([O-])=O" ; oboInOwl:hasExactSynonym "(omega-1)-hydroxy fatty acid anion" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an (omega-1)-hydroxy fatty acid" ; oboInOwl:id "CHEBI:84497" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(omega-1)-hydroxy fatty acid anion" ; rdfs:subClassOf obo:CHEBI_59835, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_78954 ] . obo:CHEBI_84690 obo:IAO_0000115 "A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0)." ; chebi:charge "0" ; chebi:formula "C54H101NO18" ; chebi:inchi "InChI=1S/C54H101NO18/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-42(60)55-37(38(59)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)36-68-52-48(66)45(63)50(40(34-57)70-52)73-54-49(67)46(64)51(41(35-58)71-54)72-53-47(65)44(62)43(61)39(33-56)69-53/h29,31,37-41,43-54,56-59,61-67H,3-28,30,32-36H2,1-2H3,(H,55,60)/b31-29+/t37-,38+,39+,40+,41+,43-,44-,45+,46+,47+,48+,49+,50+,51-,52+,53+,54-/m0/s1" ; chebi:inchikey "KWGVNZWSEWAOMI-DHCJWVHISA-N" ; chebi:mass "1052.37560" ; chebi:monoisotopicmass "1051.70187" ; chebi:smiles "CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)\\C=C\\CCCCCCCCCCCCC" ; oboInOwl:hasDbXref "LIPID_MAPS_instance:LMSP0502AA02" ; oboInOwl:hasExactSynonym "N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]octadecanamide" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "Gb3(d18:1/18:0)" ; oboInOwl:id "CHEBI:84690" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0)" ; rdfs:subClassOf obo:CHEBI_36508, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_75771 ], [ a owl:Restriction ; owl:onProperty chebi1:has_functional_parent ; owl:someValuesFrom obo:CHEBI_28842 ] . obo:CHEBI_84729 obo:IAO_0000115 "Any member of the class of indoles carrying at least one hydroxy group." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:84729" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "hydroxyindoles" ; rdfs:subClassOf obo:CHEBI_24828, obo:CHEBI_33822 . obo:CHEBI_84735 obo:IAO_0000115 "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "algal metabolites" ; oboInOwl:id "CHEBI:84735" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "algal metabolite" ; rdfs:subClassOf obo:CHEBI_75763 . obo:CHEBI_84981 obo:IAO_0000115 "A dicarboxylic acid dianion that is the conjugate base of 2-aminoadipic acid." ; chebi:charge "-2" ; chebi:formula "C6H9NO4" ; chebi:inchi "InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-2" ; chebi:inchikey "OYIFNHCXNCRBQI-UHFFFAOYSA-L" ; chebi:mass "159.14110" ; chebi:monoisotopicmass "159.05425" ; chebi:smiles "NC(CCCC([O-])=O)C([O-])=O" ; oboInOwl:hasExactSynonym "2-aminohexanedioate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "alpha-aminoadipate" ; oboInOwl:id "CHEBI:84981" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-aminoadipate(2-)" ; rdfs:subClassOf obo:CHEBI_28965, obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_37024 ] . obo:CHEBI_8504 obo:IAO_0000115 "A carbocyclic fatty acid composed of heptanoic acid having a (1S,2S)-2-octylcyclopentyl substituent at position 7." ; chebi:charge "0" ; chebi:formula "C20H38O2" ; chebi:inchi "InChI=1S/C20H38O2/c1-2-3-4-5-6-9-13-18-15-12-16-19(18)14-10-7-8-11-17-20(21)22/h18-19H,2-17H2,1H3,(H,21,22)/t18-,19-/m0/s1" ; chebi:inchikey "WGJJROVFWIXTPA-OALUTQOASA-N" ; chebi:mass "310.51452" ; chebi:monoisotopicmass "310.28718" ; chebi:smiles "CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O" ; oboInOwl:hasDbXref "Beilstein:5744307", "KEGG:C02064", "LIPID_MAPS_instance:LMFA03010000", "PMID:6234649", "Reaxys:5744307" ; oboInOwl:hasExactSynonym "7-[(1S,2S)-2-octylcyclopentyl]heptanoic acid", "Prostanoic acid", "prostan-1-oic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:8504" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "prostanoic acid" ; rdfs:subClassOf obo:CHEBI_15904, obo:CHEBI_26607, obo:CHEBI_35744 . obo:CHEBI_85234 obo:IAO_0000115 "Any metabolite (endogenous or exogenous) found in human blood serum samples." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "human blood serum metabolites" ; oboInOwl:id "CHEBI:85234" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "human blood serum metabolite" ; rdfs:subClassOf obo:CHEBI_77746 . obo:CHEBI_85425 obo:IAO_0000115 "Any substance that inhibits the action of glycine transporters." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "glycine transporter inhibitors" ; oboInOwl:id "CHEBI:85425" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "glycine transporter inhibitor" ; rdfs:subClassOf obo:CHEBI_35222 . obo:CHEBI_86327 obo:IAO_0000115 "Any antifungal agent used to prevent or treat fungal infections in humans or animals." ; oboInOwl:hasDbXref "Wikipedia:Antifungal" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "anti-fungal drug", "anti-fungal drugs", "anti-fungal medication", "anti-fungal medications", "antifungal drugs", "antifungal medication", "antifungal medications", "pharmaceutical fungicide", "pharmaceutical fungicides" ; oboInOwl:id "CHEBI:86327" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "antifungal drug" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_35441, obo:CHEBI_35718 . obo:CHEBI_86499 obo:IAO_0000115 "A hydroxy-amino acid in which the amino acid specified is proline. A \"closed\" class." ; chebi:charge "0" ; chebi:formula "C5H9NO3" ; chebi:mass "131.12990" ; chebi:monoisotopicmass "131.05824" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:86499" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monohydroxyproline" ; rdfs:subClassOf obo:CHEBI_24741 . obo:CHEBI_86508 obo:IAO_0000115 "An alpha-amino-acid anion that is the conjugate base of alpha-aminobutyric acid." ; chebi:charge "-1" ; chebi:formula "C4H8NO2" ; chebi:inchi "InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/p-1" ; chebi:inchikey "QWCKQJZIFLGMSD-UHFFFAOYSA-M" ; chebi:mass "102.11240" ; chebi:monoisotopicmass "102.05605" ; chebi:smiles "CCC(N)C([O-])=O" ; oboInOwl:hasDbXref "PMID:24023812" ; oboInOwl:hasExactSynonym "2-aminobutanoate" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:86508" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "alpha-aminobutyrate" ; rdfs:subClassOf obo:CHEBI_33558, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ], [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_35621 ] . obo:CHEBI_88071 obo:IAO_0000115 "An anionic ganglioside in which the oligosaccharide portion is composed of a disaccharide, to which one sialic acid residue is attached." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:88071" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "monosialodiglycosylceramide(1-)" ; rdfs:subClassOf obo:CHEBI_79346 . obo:CHEBI_88167 obo:IAO_0000115 "A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl component attached to the primary hydroxy function of a ceramide with undefined sphingoid base." ; chebi:charge "0" ; chebi:formula "C30H50N2O23R2" ; chebi:mass "806.719" ; chebi:monoisotopicmass "806.28044" ; chebi:smiles "[C@H]([C@@H](*)O)(NC(=O)*)CO[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@@H]([C@H](O[C@@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@H]([C@@H](O)[C@H](O4)CO)O)NC(C)=O)[C@H]([C@@H](CO)O3)O)O)[C@@H]([C@H]2O)O)CO)[C@@H]([C@H]1O)O)CO" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer", "beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer", "globoside Gb4Cer" ; oboInOwl:id "CHEBI:88167" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide" ; rdfs:subClassOf obo:CHEBI_23075, obo:CHEBI_61360 . obo:CHEBI_88184 obo:IAO_0000115 "Any metal which causes the onset of an allergic reaction." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "allergenic metal", "allergenic metals", "metal allergens" ; oboInOwl:id "CHEBI:88184" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "metal allergen" ; rdfs:subClassOf obo:CHEBI_33521, [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50904 ] . obo:CHEBI_88188 obo:IAO_0000115 "Any drug which causes the onset of an allergic reaction." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "allergenic drug" ; oboInOwl:id "CHEBI:88188" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "drug allergen" ; rdfs:subClassOf obo:CHEBI_23888, obo:CHEBI_50904 . obo:CHEBI_89843 obo:IAO_0000115 "A racemate comprising equimolar amounts of (R)- and (S)-methylsuccinic acid" ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:mass "132.115" ; chebi:monoisotopicmass "132.04226" ; oboInOwl:hasDbXref "CAS:498-21-5", "HMDB:HMDB0001844", "LIPID_MAPS_instance:LMFA01170119", "MetaCyc:CPD-2461", "Reaxys:1722946" ; oboInOwl:hasExactSynonym "rac-2-methylbutanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(+-)-methylsuccinic acid", "(RS)-2-methylbutanedioic acid", "(RS)-methylsuccinic acid", "1,2-Propanedicarboxylic acid", "2-methyl-butanedioic acid", "2-methylbutanedioic acid", "Methyl Succinic acid", "Methylbutanedioic acid", "Pyrotartaric acid" ; oboInOwl:id "CHEBI:89843" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "methylsuccinic acid" ; rdfs:subClassOf obo:CHEBI_60911, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_91316 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_91317 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_77746 ] . obo:CHEBI_90318 obo:IAO_0000115 "An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1)." ; oboInOwl:hasDbXref "Wikipedia:Pyruvate_carboxylase" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "EC 6.4.1.1 (pyruvate carboxylase) inhibitors", "EC 6.4.1.1 inhibitor", "EC 6.4.1.1 inhibitors", "pyruvate carboxylase (EC 6.4.1.1) inhibitor", "pyruvate carboxylase (EC 6.4.1.1) inhibitors", "pyruvate carboxylase inhibitor", "pyruvate carboxylase inhibitors", "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor", "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors", "pyruvic carboxylase inhibitor", "pyruvic carboxylase inhibitors" ; oboInOwl:id "CHEBI:90318" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "EC 6.4.1.1 (pyruvate carboxylase) inhibitor" ; rdfs:subClassOf obo:CHEBI_76824 . obo:CHEBI_90710 obo:IAO_0000115 "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "receptor modulators" ; oboInOwl:id "CHEBI:90710" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "receptor modulator" ; rdfs:subClassOf obo:CHEBI_23888 . obo:CHEBI_90799 obo:IAO_0000115 "Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3." ; chebi:charge "0" ; chebi:formula "C4H6N2O3R2" ; chebi:mass "130.102" ; chebi:monoisotopicmass "130.03784" ; chebi:smiles "[NH3+]C(C(NC(C([O-])=O)*)=O)*" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "a dipeptide" ; oboInOwl:id "CHEBI:90799" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "dipeptide zwitterion" ; rdfs:subClassOf obo:CHEBI_60466, [ a owl:Restriction ; owl:onProperty chebi1:is_tautomer_of ; owl:someValuesFrom obo:CHEBI_46761 ] . obo:CHEBI_91007 obo:IAO_0000115 "A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3." ; chebi:charge "-1" ; chebi:formula "CO2R" ; chebi:mass "44.010" ; chebi:monoisotopicmass "43.98983" ; chebi:smiles "*C([O-])=O" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "an aromatic carboxylate" ; oboInOwl:id "CHEBI:91007" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "aromatic carboxylate" ; rdfs:subClassOf obo:CHEBI_29067, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_base_of ; owl:someValuesFrom obo:CHEBI_33859 ] . obo:CHEBI_91315 obo:IAO_0000115 "A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group." ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-3(5(8)9)2-4(6)7/h3H,2H2,1H3,(H,6,7)(H,8,9)" ; chebi:inchikey "WXUAQHNMJWJLTG-UHFFFAOYSA-N" ; chebi:mass "132.115" ; chebi:monoisotopicmass "132.04226" ; chebi:smiles "OC(=O)C(CC(O)=O)C" ; oboInOwl:hasExactSynonym "2-methylbutanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:id "CHEBI:91315" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "2-methylbutanedioic acid" ; rdfs:subClassOf obo:CHEBI_35692, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_132961 ] . obo:CHEBI_91316 obo:IAO_0000115 "A 2-methylbutanedioic acid in which the methyl group at position 2 has S-configuration." ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-3(5(8)9)2-4(6)7/h3H,2H2,1H3,(H,6,7)(H,8,9)/t3-/m0/s1" ; chebi:inchikey "WXUAQHNMJWJLTG-VKHMYHEASA-N" ; chebi:mass "132.115" ; chebi:monoisotopicmass "132.04226" ; chebi:smiles "OC(=O)[C@H](CC(O)=O)C" ; oboInOwl:hasDbXref "Reaxys:1722948" ; oboInOwl:hasExactSynonym "(2S)-2-methylbutanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(S)-2-methylbutanedioic acid" ; oboInOwl:id "CHEBI:91316" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(S)-methylsuccinic acid" ; rdfs:subClassOf obo:CHEBI_91315, [ a owl:Restriction ; owl:onProperty chebi1:is_conjugate_acid_of ; owl:someValuesFrom obo:CHEBI_191220 ], [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_91317 ] . obo:CHEBI_91317 obo:IAO_0000115 "A 2-methylbutanedioic acid in which the methyl group at position 2 has R-configuration." ; chebi:charge "0" ; chebi:formula "C5H8O4" ; chebi:inchi "InChI=1S/C5H8O4/c1-3(5(8)9)2-4(6)7/h3H,2H2,1H3,(H,6,7)(H,8,9)/t3-/m1/s1" ; chebi:inchikey "WXUAQHNMJWJLTG-GSVOUGTGSA-N" ; chebi:mass "132.115" ; chebi:monoisotopicmass "132.04226" ; chebi:smiles "OC(=O)[C@@H](CC(O)=O)C" ; oboInOwl:hasDbXref "CAS:3641-51-8", "Reaxys:1722947" ; oboInOwl:hasExactSynonym "(2R)-2-methylbutanedioic acid" ; oboInOwl:hasOBONamespace "chebi_ontology" ; oboInOwl:hasRelatedSynonym "(R)-2-methylbutanedioic acid", "d-Methylsuccinic acid" ; oboInOwl:id "CHEBI:91317" ; oboInOwl:inSubset chebi4:_STAR ; a owl:Class ; rdfs:label "(R)-methylsuccinic acid" ; rdfs:subClassOf obo:CHEBI_91315, [ a owl:Restriction ; owl:onProperty chebi1:is_enantiomer_of ; owl:someValuesFrom obo:CHEBI_91316 ] . obo:CL_0000000 obo:IAO_0000115 "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ; oboInOwl:hasDbXref "CALOHA:TS-2035", "FBbt:00007002", "FMA:68646", "GO:0005623", "KUPO:0000002", "MESH:D002477", "VHOG:0001533", "WBbt:0004017", "XAO:0003012" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:comment "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ; rdfs:label "cell" ; rdfs:subClassOf obo:UBERON_0000061 . obo:CL_0000003 obo:IAO_0000115 "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." ; oboInOwl:hasDbXref "CARO:0000013" ; oboInOwl:hasNarrowSynonym "cell in vivo" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:comment "To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12)." ; rdfs:label "native cell" ; rdfs:subClassOf obo:CL_0000000 . obo:CL_0000005 obo:IAO_0000115 "Any fibroblast that is deriived from the neural crest." ; a owl:Class ; rdfs:label "fibroblast neural crest derived" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0000006 oboInOwl:hasExactSynonym "neuronal receptor cell (sensu Animalia)" ; a owl:Class ; rdfs:label "neuronal receptor cell" ; rdfs:subClassOf obo:CL_0000197 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000197 obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_0000007 obo:IAO_0000115 "A cell found in the embryo before the formation of all the gem layers is complete." ; a owl:Class ; rdfs:label "early embryonic cell (metazoa)" ; rdfs:subClassOf obo:CL_0002321 . obo:CL_0000008 obo:IAO_0000115 "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." ; a owl:Class ; rdfs:label "migratory cranial neural crest cell" ; rdfs:subClassOf obo:CL_0000333 . obo:CL_0000011 obo:IAO_0000115 "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." ; a owl:Class ; rdfs:label "migratory trunk neural crest cell" ; rdfs:subClassOf obo:CL_0000333 . obo:CL_0000014 obo:IAO_0000115 "A stem cell that is the precursor of gametes." ; oboInOwl:hasDbXref "FBbt:00004861" ; oboInOwl:hasExactSynonym "germline stem cell" ; a owl:Class ; rdfs:label "germ line stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0000039 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000039 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000015 obo:IAO_0000115 "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." ; oboInOwl:hasDbXref "FMA:72290", "MA:0002765", "VHOG:0001531", "ncithesaurus:Spermatogenic_Cell" ; a owl:Class ; rdfs:label "male germ cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/574" ; rdfs:subClassOf obo:CL_0000586, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007283 ] . obo:CL_0000017 obo:IAO_0000115 "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." ; oboInOwl:hasDbXref "BTO:0001275", "CALOHA:TS-0951", "EMAPA:31484", "FBbt:00004936", "FMA:84049", "WBbt:0006799" ; a owl:Class ; rdfs:label "spermatocyte" ; rdfs:subClassOf obo:CL_0000015, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048137 ] ) ] . obo:CL_0000018 obo:IAO_0000115 "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." ; oboInOwl:hasDbXref "BTO:0001274", "CALOHA:TS-0950", "EMAPA:31486", "FBbt:00004942", "FMA:72294", "WBbt:0006800" ; oboInOwl:hasExactSynonym "nematoblast" ; a owl:Class ; rdfs:label "spermatid" ; rdfs:subClassOf obo:CL_0000015, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000657 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001675 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007289 ] ) ] . obo:CL_0000019 obo:IAO_0000115 "A mature male germ cell that develops from a spermatid." ; oboInOwl:hasDbXref "BTO:0001277", "BTO:0002046", "CALOHA:TS-0949", "FBbt:00004954", "FMA:67338", "WBbt:0006798" ; oboInOwl:hasExactSynonym "sperm cell", "spermatozoid", "spermatozoon" ; a owl:Class ; rdfs:label "sperm" ; rdfs:subClassOf obo:CL_0000408, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000018 ] . obo:CL_0000020 obo:IAO_0000115 "An euploid male germ cell of an early stage of spermatogenesis." ; oboInOwl:hasDbXref "BTO:0000958", "CALOHA:TS-2193", "EMAPA:31482", "FBbt:00004934", "FBbt:00004935", "FMA:72291" ; oboInOwl:hasExactSynonym "spermatogonial cell" ; a owl:Class ; rdfs:label "spermatogonium" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0000021 obo:IAO_0000115 "Female germ cell is a germ cell that supports female gamete production." ; oboInOwl:hasDbXref "MA:0000388", "VHOG:0001530", "ncithesaurus:Egg" ; a owl:Class ; rdfs:label "female germ cell" ; rdfs:subClassOf obo:CL_0000586 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:CL_0000022 obo:IAO_0000115 "A stem cell that is the precursor of female gametes." ; oboInOwl:hasDbXref "FBbt:00004873" ; a owl:Class ; rdfs:label "female germ line stem cell" ; rdfs:subClassOf obo:CL_0000014, obo:CL_0000021 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000021 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000023 obo:IAO_0000115 "A female germ cell that has entered meiosis." ; oboInOwl:hasDbXref "BTO:0000964", "CALOHA:TS-0711", "FBbt:00004886", "FMA:18644", "MESH:D009865", "WBbt:0006797" ; oboInOwl:hasRelatedSynonym "oogonium" ; a owl:Class ; rdfs:label "oocyte" ; rdfs:subClassOf obo:CL_0000021, [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0007143 ] . obo:CL_0000024 obo:IAO_0000115 "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." ; oboInOwl:hasDbXref "FMA:83673" ; a owl:Class ; rdfs:label "oogonial cell" ; rdfs:subClassOf obo:CL_0000021, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000670 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000021 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:CL_0000027 obo:IAO_0000115 "A smooth muscle cell derived from the neural crest." ; a owl:Class ; rdfs:label "smooth muscle cell neural crest derived" ; rdfs:subClassOf obo:CL_0000192, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0000029 oboInOwl:hasExactSynonym "neuron neural crest derived" ; a owl:Class ; rdfs:label "neural crest derived neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002676 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0000030 a owl:Class ; rdfs:label "glioblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0000031 obo:IAO_0000115 "A cell that will develop into a neuron often after a migration phase." ; oboInOwl:hasDbXref "BTO:0000930", "FMA:70563" ; oboInOwl:hasExactSynonym "neuroblast" ; a owl:Class ; rdfs:label "neuroblast (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000055 . obo:CL_0000034 obo:IAO_0000115 "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." ; oboInOwl:hasDbXref "CALOHA:TS-2086", "FMA:63368" ; oboInOwl:hasExactSynonym "animal stem cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ; rdfs:label "stem cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000035 obo:IAO_0000115 "A stem cell that self-renews as well as give rise to a single mature cell type." ; oboInOwl:hasDbXref "FMA:70569" ; oboInOwl:hasExactSynonym "unipotent stem cell", "unipotential stem cell" ; a owl:Class ; rdfs:label "single fate stem cell" ; rdfs:subClassOf obo:CL_0000723 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000036 oboInOwl:hasExactSynonym "epithelial stem cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial fate stem cell" ; rdfs:subClassOf obo:CL_0000035 . obo:CL_0000037 obo:IAO_0000115 "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." ; oboInOwl:hasDbXref "BTO:0000725", "CALOHA:TS-0448", "FMA:70337", "FMA:86475", "MESH:D006412", "VHOG:0001485" ; oboInOwl:hasExactSynonym "HSC", "blood forming stem cell", "hemopoietic stem cell" ; oboInOwl:hasRelatedSynonym "colony forming unit hematopoietic" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ; rdfs:label "hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000988, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048103 ] ) ] . obo:CL_0000038 obo:IAO_0000115 "A progenitor cell committed to the erythroid lineage." ; oboInOwl:hasDbXref "BTO:0004911" ; oboInOwl:hasRelatedSynonym "BFU-E", "CFU-E", "blast forming unit erythroid", "burst forming unit erythroid", "colony forming unit erythroid", "erythroid stem cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000764, obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ] . obo:CL_0000039 obo:IAO_0000115 "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." ; oboInOwl:inSubset cl:general_cell_types_upper_slim, ubprop:_upper_level ; a owl:Class ; rdfs:comment "Originally this term had some plant germ line cell children." ; rdfs:label "germ line cell" ; rdfs:subClassOf obo:CL_0000003, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0022414 ] ; owl:disjointWith obo:CL_0002371 . obo:CL_0000040 obo:IAO_0000115 "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." ; oboInOwl:hasDbXref "CALOHA:TS-1195", "FMA:83553" ; oboInOwl:hasRelatedSynonym "CFU-M", "colony forming unit macrophage", "colony forming unit monocyte", "monocyte stem cell" ; a owl:Class ; rdfs:comment "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ; rdfs:label "monoblast" ; rdfs:subClassOf obo:CL_0002194, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002194 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0000048 obo:IAO_0000115 "A stem cell that can give rise to multiple lineages of cells." ; oboInOwl:hasDbXref "FMA:84789" ; oboInOwl:hasExactSynonym "multi-fate stem cell", "multifate stem cell", "multipotent cell", "multipotent stem cell" ; a owl:Class ; rdfs:label "multi fate stem cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002371 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:CL_0000049 obo:IAO_0000115 "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." ; oboInOwl:hasDbXref "BTO:0004730" ; oboInOwl:hasExactSynonym "CMP", "common myeloid precursor" ; oboInOwl:hasRelatedSynonym "CFU-GEMM", "CFU-S", "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "multipotential myeloid stem cell", "myeloid stem cell", "pluripotent stem cell (bone marrow)" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ; rdfs:label "common myeloid progenitor" ; rdfs:subClassOf obo:CL_0002032 ; owl:disjointWith obo:CL_0000050, obo:CL_0000051, obo:CL_0000557 . obo:CL_0000050 obo:IAO_0000115 "A progenitor cell committed to the megakaryocyte and erythroid lineages." ; oboInOwl:hasExactSynonym "CFU-EM", "CFU-MegE", "MEP", "Meg/E progenitor", "colony forming unit erythroid megakaryocyte", "megakaryocyte/erythrocyte progenitor", "megakaryocyte/erythroid progenitor cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ; rdfs:label "megakaryocyte-erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0002032, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ; owl:disjointWith obo:CL_0000557, obo:CL_0002009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:CL_0000051 obo:IAO_0000115 "A oligopotent progenitor cell committed to the lymphoid lineage." ; oboInOwl:hasExactSynonym "CLP", "common lymphocyte precursor", "common lymphocyte progenitor", "common lymphoid precursor" ; oboInOwl:hasRelatedSynonym "ELP", "committed lymphopoietic stem cell", "early lymphocyte progenitor", "lymphoid stem cell", "lymphopoietic stem cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ; rdfs:label "common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0002032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000052 obo:IAO_0000115 "A stem cell from which all cells of the body can form." ; oboInOwl:hasDbXref "FMA:84790", "MESH:D039901" ; oboInOwl:hasExactSynonym "totipotential stem cell" ; a owl:Class ; rdfs:label "totipotent stem cell" ; rdfs:subClassOf obo:CL_0000723 . obo:CL_0000055 obo:IAO_0000115 "A precursor cell with a limited number of potential fates." ; oboInOwl:hasDbXref "BTO:0000125", "FMA:84782" ; oboInOwl:hasExactSynonym "blast cell" ; a owl:Class ; rdfs:comment "define using PATO mulit-potent or oligopotent?" ; rdfs:label "non-terminally differentiated cell" ; rdfs:subClassOf obo:CL_0000003, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] . obo:CL_0000056 obo:IAO_0000115 "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." ; oboInOwl:hasDbXref "BTO:0000222", "CALOHA:TS-0650", "FBbt:00005083", "FMA:70335", "VHOG:0001529" ; a owl:Class ; rdfs:label "myoblast" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0000680 . obo:CL_0000057 obo:IAO_0000115 "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ; oboInOwl:hasDbXref "BTO:0000452", "CALOHA:TS-0362", "FMA:63877", "NCIT:C12482", "VHOG:0001482" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ; rdfs:label "fibroblast" ; rdfs:subClassOf obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000058 obo:IAO_0000115 "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." ; oboInOwl:hasDbXref "BTO:0003607", "FMA:66783" ; oboInOwl:hasExactSynonym "chrondoplast" ; a owl:Class ; rdfs:label "chondroblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0002418 ] . obo:CL_0000059 obo:IAO_0000115 "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." ; oboInOwl:hasDbXref "BTO:0001663", "FMA:70576" ; oboInOwl:hasExactSynonym "amelocyte", "enamel secreting cell" ; a owl:Class ; rdfs:comment "non-encoded relationship from VSAO produces VSAO:0000066" ; rdfs:label "ameloblast" ; rdfs:subClassOf obo:CL_0000146, obo:CL_0000151, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097186 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001763 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001752 ] . obo:CL_0000060 obo:IAO_0000115 "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." ; oboInOwl:hasDbXref "BTO:0001769", "CALOHA:TS-0696", "FMA:62999", "MESH:D009804" ; a owl:Class ; rdfs:comment "legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin." ; rdfs:label "odontoblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0002148, obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001751 ] . obo:CL_0000064 obo:IAO_0000115 "A cell that has a filiform extrusion of the cell surface." ; oboInOwl:hasDbXref "VHOG:0001532", "XAO:0000031" ; a owl:Class ; rdfs:label "ciliated cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] . obo:CL_0000066 obo:IAO_0000115 "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." ; oboInOwl:hasDbXref "BTO:0000414", "CALOHA:TS-2026", "CARO:0000077", "FBbt:00000124", "FMA:66768", "WBbt:0003672" ; oboInOwl:hasExactSynonym "epitheliocyte" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ; owl:disjointWith obo:CL_0000738 . obo:CL_0000067 obo:IAO_0000115 "An epithelial cell that has a cilia." ; oboInOwl:hasDbXref "FMA:70605" ; a owl:Class ; rdfs:label "ciliated epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] . obo:CL_0000068 obo:IAO_0000115 "An epithelial cell that is part of a duct." ; a owl:Class ; rdfs:label "duct epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000058 ] ) ] . obo:CL_0000069 a owl:Class ; rdfs:label "branched duct epithelial cell" ; rdfs:subClassOf obo:CL_0000068 . obo:CL_0000071 obo:IAO_0000115 "An endothelial cell that lines the vasculature." ; oboInOwl:hasExactSynonym "cuboidal endothelial cell of vascular tree" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "blood vessel endothelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0002139, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002546 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004638 ] ) ] . obo:CL_0000072 a owl:Class ; rdfs:label "non-branched duct epithelial cell" ; rdfs:subClassOf obo:CL_0000068, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] . obo:CL_0000075 obo:IAO_0000115 "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "columnar/cuboidal epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 . obo:CL_0000076 oboInOwl:hasDbXref "CALOHA:TS-1249" ; a owl:Class ; rdfs:label "squamous epithelial cell" ; rdfs:subClassOf obo:CL_0000066 . obo:CL_0000077 obo:IAO_0000115 "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." ; oboInOwl:hasDbXref "FMA:66773" ; oboInOwl:hasExactSynonym "mesotheliocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesothelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0000213, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] . obo:CL_0000079 a owl:Class ; rdfs:label "stratified epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000357 ] . obo:CL_0000080 obo:IAO_0000115 "A cell which moves among different tissues of the body, via blood, lymph, or other medium." ; a owl:Class ; rdfs:label "circulating cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000179 ] ) ] . obo:CL_0000081 obo:IAO_0000115 "A cell found predominately in the blood." ; oboInOwl:hasDbXref "FMA:62844", "MESH:D001773" ; oboInOwl:inSubset cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "blood cell" ; rdfs:subClassOf obo:CL_0000988 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:CL_0000082 obo:IAO_0000115 "An epithelial cell of the lung." ; oboInOwl:hasDbXref "BTO:0004299" ; oboInOwl:hasExactSynonym "lung epithelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of lung" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000115 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_0000083 obo:IAO_0000115 "An epithelial cell of the pancreas." ; oboInOwl:hasDbXref "BTO:0000028" ; oboInOwl:hasExactSynonym "pancreas epithelial cell", "pancreatic epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of pancreas" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000223 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0000084 obo:IAO_0000115 "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." ; oboInOwl:hasDbXref "BTO:0000782", "CALOHA:TS-1001", "FMA:62870", "MESH:D013601", "VHOG:0001479" ; oboInOwl:hasExactSynonym "T lymphocyte", "T-cell", "T-lymphocyte" ; oboInOwl:hasRelatedSynonym "immature T cell", "mature T cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "T cell" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000827 ] ; owl:disjointWith obo:CL_0000945 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002456 ] ) ] . obo:CL_0000094 obo:IAO_0000115 "A leukocyte with abundant granules in the cytoplasm." ; oboInOwl:hasDbXref "BTO:0000539", "BTO:0001026", "CALOHA:TS-0422", "FMA:62854" ; oboInOwl:hasExactSynonym "granular leucocyte", "granular leukocyte", "polymorphonuclear leukocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "granulocyte" ; rdfs:subClassOf obo:CL_0000766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001969 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:CL_0000095 a owl:Class ; rdfs:label "neuron associated cell" ; rdfs:subClassOf obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0000097 obo:IAO_0000115 "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." ; oboInOwl:hasDbXref "BTO:0000830", "CALOHA:TS-0603", "FMA:66784" ; oboInOwl:hasExactSynonym "histaminocyte", "labrocyte", "mastocyte" ; oboInOwl:hasRelatedSynonym "tissue basophil" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5." ; rdfs:label "mast cell" ; rdfs:subClassOf obo:CL_0000766, obo:CL_0002274, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030141 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000006169 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002539 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002660 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000098 obo:IAO_0000115 "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." ; oboInOwl:hasBroadSynonym "neuroepithelial cell" ; oboInOwl:hasDbXref "BTO:0004301" ; a owl:Class ; rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ; rdfs:label "sensory epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000197, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_0000099 obo:IAO_0000115 "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." ; oboInOwl:hasDbXref "BTO:0003811", "FBbt:00005125", "FMA:67313", "WBbt:0005113" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "interneuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0000100 obo:IAO_0000115 "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." ; oboInOwl:hasDbXref "BTO:0000312", "FBbt:00005123", "FMA:83617", "WBbt:0005409" ; oboInOwl:hasExactSynonym "motoneuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "motor neuron" ; rdfs:subClassOf obo:CL_0000527 . obo:CL_0000101 obo:IAO_0000115 "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." ; oboInOwl:hasDbXref "BTO:0001037", "FBbt:00005124", "FMA:84649", "MESH:D011984", "WBbt:0005759" ; a owl:Class ; rdfs:label "sensory neuron" ; rdfs:subClassOf obo:CL_0000526 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_0000103 obo:IAO_0000115 "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." ; oboInOwl:hasDbXref "FMA:67282" ; oboInOwl:inSubset cl:BDS_subset ; a owl:Class ; rdfs:label "bipolar neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070006 ] ) ] . obo:CL_0000107 obo:IAO_0000115 "A neuron whose cell body is within an autonomic ganglion." ; oboInOwl:hasDbXref "FMA:80121" ; a owl:Class ; rdfs:label "autonomic neuron" ; rdfs:subClassOf obo:CL_0000540 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002410 ] ) ] . obo:CL_0000108 obo:IAO_0000115 "A neuron that uses acetylcholine as a vesicular neurotransmitter." ; oboInOwl:hasDbXref "BTO:0004902", "FBbt:00007173", "FMA:84796", "MESH:D059329", "WBbt:0006840" ; a owl:Class ; rdfs:label "cholinergic neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] ) ] . obo:CL_0000111 obo:IAO_0000115 "OBSOLETE A neuron that is part of nerve found outside the central nervous system." ; obo:IAO_0000231 obo:IAO_0000227 ; obo:IAO_0100001 obo:CL_2000032 ; oboInOwl:hasDbXref "FMA:84664" ; a owl:Class ; rdfs:comment "Merging into CL:2000032, see https://github.com/obophenotype/cell-ontology/issues/1069" ; rdfs:label "obsolete peripheral neuron" ; owl:deprecated true . obo:CL_0000114 oboInOwl:hasDbXref "FMA:72552" ; oboInOwl:hasExactSynonym "cell of surface ectoderm", "surface ectoderm cell" ; a owl:Class ; rdfs:label "surface ectodermal cell" ; rdfs:subClassOf obo:CL_0000221 . obo:CL_0000115 obo:IAO_0000115 "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." ; oboInOwl:hasDbXref "BTO:0001176", "CALOHA:TS-0278", "FMA:66772" ; oboInOwl:hasExactSynonym "endotheliocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ; rdfs:label "endothelial cell" ; rdfs:subClassOf obo:CL_0000213, obo:CL_0002078 . obo:CL_0000117 a owl:Class ; rdfs:label "CNS neuron (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000031 ] . obo:CL_0000119 obo:IAO_0000115 "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." ; oboInOwl:hasDbXref "MESH:D000080906" ; oboInOwl:hasExactSynonym "Golgi cell", "Golgi neuron", "cerebellar Golgi neuron", "cerebellum Golgi cell" ; a owl:Class ; rdfs:label "cerebellar Golgi cell" ; rdfs:subClassOf obo:CL_0011005, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002129 ] . obo:CL_0000120 obo:IAO_0000115 "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." ; oboInOwl:hasDbXref "BTO:0003393" ; a owl:Class ; rdfs:label "granule cell" ; rdfs:subClassOf obo:CL_0000117 . obo:CL_0000121 obo:IAO_0000115 "The output neuron of the cerebellar cortex." ; oboInOwl:hasDbXref "BTO:0001011", "CALOHA:TS-0845", "FMA:67969" ; oboInOwl:hasExactSynonym "Purkinje neuron", "Purkinje's cell", "cerebellar Purkinje cell", "cerebellum Purkinje cell" ; a owl:Class ; rdfs:label "Purkinje cell" ; rdfs:subClassOf obo:CL_0000117, obo:CL_0000527, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002129 ] . obo:CL_0000123 a owl:Class ; rdfs:label "neuron associated cell (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000095, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0000125 obo:IAO_0000115 "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." ; oboInOwl:hasDbXref "BTO:0002606", "CALOHA:TS-0415", "FBbt:00005144", "FMA:54536" ; oboInOwl:hasExactSynonym "neuroglial cell" ; oboInOwl:hasRelatedSynonym "neuroglia" ; oboInOwl:inSubset cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:comment "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ; rdfs:label "glial cell" ; rdfs:subClassOf obo:CL_0000095 . obo:CL_0000126 obo:IAO_0000115 "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." ; oboInOwl:hasDbXref "BTO:0000771", "CALOHA:TS-2027", "FMA:54538" ; oboInOwl:hasExactSynonym "macrogliocyte" ; a owl:Class ; rdfs:label "macroglial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000339 ] . obo:CL_0000127 obo:IAO_0000115 "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." ; oboInOwl:hasDbXref "BTO:0000099", "CALOHA:TS-0060", "FMA:54537" ; oboInOwl:hasExactSynonym "astrocytic glia" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive." ; rdfs:label "astrocyte" ; rdfs:subClassOf obo:CL_0000126 . obo:CL_0000128 obo:IAO_0000115 "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." ; oboInOwl:hasDbXref "BTO:0000962", "CALOHA:TS-0709", "FMA:54540" ; oboInOwl:hasExactSynonym "OLs" ; oboInOwl:hasRelatedSynonym "oligodendroglia" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Oligodendrocytes are reportedly MDP-positive and CD4-negative." ; rdfs:label "oligodendrocyte" ; rdfs:subClassOf obo:CL_0000126, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043209 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002453 ] . obo:CL_0000129 obo:IAO_0000115 "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." ; oboInOwl:hasBroadSynonym "brain macrophage" ; oboInOwl:hasDbXref "BTO:0000078", "BTO:0000962", "FMA:54539", "FMA:54540" ; oboInOwl:hasExactSynonym "brain-resident macrophage", "hortega cells", "microglia", "microgliocyte" ; oboInOwl:hasRelatedSynonym "MF.microglia.CNS" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive." ; rdfs:label "microglial cell" ; rdfs:subClassOf obo:CL_0000878, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0000133 obo:IAO_0000115 "Ectoderm destined to be nervous tissue." ; oboInOwl:hasExactSynonym "neurectoderm cell" ; a owl:Class ; rdfs:label "neurectodermal cell" ; rdfs:subClassOf obo:CL_0000221 . obo:CL_0000134 obo:IAO_0000115 "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." ; oboInOwl:hasDbXref "BTO:0002625", "BTO:0003298", "FMA:70546" ; oboInOwl:hasNarrowSynonym "BMSC", "bone marrow stromal cells", "colony-forming unit-fibroblast", "marrow stromal cells" ; oboInOwl:hasRelatedSynonym "CFU-F", "MSC", "mesenchymal precursor cell", "mesenchymal progenitor cells", "mesenchymal stem cell", "mesenchymal stromal cell", "mesenchymal stromal cells", "stem cells, mesenchymal" ; a owl:Class ; rdfs:comment "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ; rdfs:label "mesenchymal stem cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/474" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002320 . obo:CL_0000136 obo:IAO_0000115 "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." ; oboInOwl:hasDbXref "BTO:0000443", "CALOHA:TS-0012", "FMA:63880" ; oboInOwl:hasExactSynonym "adipocyte", "adipose cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "fat cell" ; rdfs:subClassOf obo:CL_0000325, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000138 obo:IAO_0000115 "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." ; oboInOwl:hasDbXref "BTO:0000249", "CALOHA:TS-0138", "FMA:66782" ; oboInOwl:hasExactSynonym "cartilage cell" ; a owl:Class ; rdfs:label "chondrocyte" ; rdfs:subClassOf obo:CL_0000153, obo:CL_0000667, obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002418 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000058 ] . obo:CL_0000145 obo:IAO_0000115 "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." ; oboInOwl:hasBroadSynonym "APC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ; rdfs:label "professional antigen presenting cell" ; rdfs:subClassOf obo:CL_0000738 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] ) ] . obo:CL_0000146 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "simple columnar epithelial cell" ; rdfs:subClassOf obo:CL_0000075 . obo:CL_0000147 obo:IAO_0000115 "A pigment cell is a cell that contains pigment granules." ; oboInOwl:hasDbXref "VHOG:0001678" ; oboInOwl:hasExactSynonym "chromatocyte", "chromatophore" ; a owl:Class ; rdfs:label "pigment cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000148 obo:IAO_0000115 "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." ; oboInOwl:hasDbXref "BTO:0000847", "CALOHA:TS-0613", "FMA:70545", "MESH:D008544", "VHOG:0001679" ; oboInOwl:hasNarrowSynonym "melanophore" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "melanocyte" ; rdfs:subClassOf obo:CL_0000147, obo:CL_0000548, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000147 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042470 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000541 ] ) ] . obo:CL_0000149 oboInOwl:hasBroadSynonym "pigment cell" ; a owl:Class ; rdfs:label "visual pigment cell" ; rdfs:subClassOf obo:CL_0000147, obo:CL_0000548 . obo:CL_0000150 obo:IAO_0000115 "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." ; oboInOwl:hasDbXref "CALOHA:TS-2085", "FMA:86494" ; a owl:Class ; rdfs:label "glandular epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000151, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006799 ] . obo:CL_0000151 obo:IAO_0000115 "A cell that specializes in controlled release of one or more substances." ; oboInOwl:hasDbXref "BTO:0003659", "FMA:86916" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "secretory cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:CL_0000152 obo:IAO_0000115 "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." ; oboInOwl:hasDbXref "FMA:16014" ; oboInOwl:inSubset cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "exocrine cell" ; rdfs:subClassOf obo:CL_0000151, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002365 ] ) ] . obo:CL_0000153 obo:IAO_0000115 "A cell that secretes glycosaminoglycans." ; oboInOwl:hasExactSynonym "GAG secreting cell" ; oboInOwl:hasNarrowSynonym "hyaluronic acid secreting cell" ; a owl:Class ; rdfs:label "glycosaminoglycan secreting cell" ; rdfs:subClassOf obo:CL_0000327, obo:CL_0000447 . obo:CL_0000154 a owl:Class ; rdfs:label "protein secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009306 ] ) ] . obo:CL_0000157 obo:IAO_0000115 "A cell that specializes in secretion of surfactant in the alveoli of the lung." ; a owl:Class ; rdfs:label "surfactant secreting cell" ; rdfs:subClassOf obo:CL_0000151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] ) ] . obo:CL_0000158 obo:IAO_0000115 "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." ; oboInOwl:hasDbXref "BTO:0004811", "FMA:14119" ; oboInOwl:hasExactSynonym "Clara cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "club cell" ; rdfs:subClassOf obo:CL_0002202, obo:CL_0011026, [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0005902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] . obo:CL_0000159 a owl:Class ; rdfs:label "seromucus secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000160 obo:IAO_0000115 "A cell of the epithelial lining that produce and secrete mucins." ; oboInOwl:hasDbXref "BTO:0001540", "FMA:13148", "http://en.wikipedia.org/wiki/Goblet_cell" ; oboInOwl:hasExactSynonym "chalice cell" ; a owl:Class ; rdfs:label "goblet cell" ; rdfs:subClassOf obo:CL_0000150, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] . obo:CL_0000161 a owl:Class ; rdfs:label "acid secreting cell" ; rdfs:subClassOf obo:CL_0000151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046717 ] ) ] . obo:CL_0000163 obo:IAO_0000115 "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." ; oboInOwl:hasDbXref "FMA:83809" ; oboInOwl:hasExactSynonym "endocrinocyte" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "endocrine cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0046879 [ a owl:Restriction ; owl:onProperty obo:RO_0002339 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] ] ) ] . obo:CL_0000164 obo:IAO_0000115 "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." ; oboInOwl:hasDbXref "BTO:0003865", "FMA:62930", "MESH:D019858" ; a owl:Class ; rdfs:label "enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000163 . obo:CL_0000165 obo:IAO_0000115 "A neuron that is capable of some hormone secretion in response to neuronal signals." ; oboInOwl:hasDbXref "BTO:0002691", "FBbt:00005130", "FMA:83810" ; oboInOwl:hasRelatedSynonym "neurosecretory cell", "neurosecretory neuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment """The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.""" ; rdfs:label "neuroendocrine cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000393, obo:CL_0000527, obo:CL_0000710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:CL_0000166 obo:IAO_0000115 "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." ; oboInOwl:hasDbXref "BTO:0000259", "FMA:69263" ; oboInOwl:hasExactSynonym "phaeochromocyte" ; a owl:Class ; rdfs:label "chromaffin cell" ; rdfs:subClassOf obo:CL_0000568, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0000167 a owl:Class ; rdfs:label "peptide hormone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030072 ] ) ] . obo:CL_0000168 oboInOwl:hasDbXref "BTO:0000783" ; a owl:Class ; rdfs:label "insulin secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:CL_0000169 obo:IAO_0000115 "A cell that secretes insulin and is located towards the center of the islets of Langerhans." ; oboInOwl:hasBroadSynonym "beta cell" ; oboInOwl:hasDbXref "BTO:0000783", "EV:0200009", "FMA:70586", "MA:0002419", "ncithesaurus:Beta_Cell" ; oboInOwl:hasExactSynonym "B-cell of pancreatic islet", "beta cell of pancreatic islet", "insulin-secreting cell", "pancreatic B cell", "pancreatic B-cell", "pancreatic beta cell", "pancreatic islet core", "type B enteroendocrine cell" ; oboInOwl:hasRelatedSynonym "beta cell islet" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ; rdfs:label "type B pancreatic cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000168, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:CL_0000170 obo:IAO_0000115 "A cell that secretes glucagon." ; oboInOwl:hasDbXref "FMA:84045" ; oboInOwl:hasExactSynonym "glucagon-secreting cell" ; a owl:Class ; rdfs:label "glucagon secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:CL_0000171 obo:IAO_0000115 "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." ; oboInOwl:hasDbXref "BTO:0000990", "FMA:70585", "MESH:D050416" ; oboInOwl:hasExactSynonym "alpha cell of islet of Langerhans", "pancreatic alpha cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic A cell" ; rdfs:subClassOf obo:CL_0002067, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0000172 a owl:Class ; rdfs:label "somatostatin secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070253 ] ) ] . obo:CL_0000173 obo:IAO_0000115 "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." ; oboInOwl:hasDbXref "BTO:0000803", "FMA:70587" ; oboInOwl:hasExactSynonym "D-cell of pancreatic islet", "delta cell of islet", "delta cell of pancreatic islet", "pancreatic D-cell", "pancreatic delta cell", "somatostatin-secreting pancreatic cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic D cell" ; rdfs:subClassOf obo:CL_0000502, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0000174 a owl:Class ; rdfs:label "steroid hormone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035929 ] ) ] . obo:CL_0000177 a owl:Class ; rdfs:label "testosterone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035936 ] ) ] . obo:CL_0000178 obo:IAO_0000115 "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." ; oboInOwl:hasBroadSynonym "interstitial cell" ; oboInOwl:hasDbXref "BTO:0000755", "CALOHA:TS-1150", "EMAPA:29655", "FMA:72297", "MESH:D007985" ; oboInOwl:hasExactSynonym "interstitial cell of Leydig" ; a owl:Class ; rdfs:comment "Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated" ; rdfs:label "Leydig cell" ; rdfs:subClassOf obo:CL_0000177, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0009091 ] . obo:CL_0000182 obo:IAO_0000115 "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." ; oboInOwl:hasDbXref "BTO:0000575", "CALOHA:TS-0454", "FMA:14515" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive." ; rdfs:label "hepatocyte" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000417, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006699 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0044237 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0098754 ] . obo:CL_0000183 obo:IAO_0000115 "A cell whose primary function is to shorten." ; a owl:Class ; rdfs:label "contractile cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000187 obo:IAO_0000115 "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." ; oboInOwl:hasDbXref "BTO:0000888", "BTO:0000902", "CALOHA:TS-2032", "FBbt:00005074", "FMA:67328", "WBbt:0003675" ; oboInOwl:hasExactSynonym "muscle fiber", "myocyte" ; a owl:Class ; rdfs:label "muscle cell" ; rdfs:subClassOf obo:CL_0000183, obo:CL_0000393, obo:CL_0000548, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000056 ] . obo:CL_0000188 obo:IAO_0000115 "A somatic cell located in skeletal muscle." ; oboInOwl:hasDbXref "BTO:0004392", "CALOHA:TS-2158", "FMA:9727" ; oboInOwl:hasExactSynonym "skeletal muscle cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "cell of skeletal muscle" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:CL_0000192 obo:IAO_0000115 "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." ; oboInOwl:hasBroadSynonym "non-striated muscle cell" ; oboInOwl:hasDbXref "BTO:0004576", "CALOHA:TS-2159", "FMA:14072" ; oboInOwl:hasExactSynonym "SMCs", "myocytes, smooth muscle", "smooth muscle fiber" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell" ; rdfs:subClassOf obo:CL_0008000, obo:CL_0008007, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000514 ] . obo:CL_0000197 obo:IAO_0000115 "A cell that is capable of detection of a stimulus involved in sensory perception." ; oboInOwl:hasDbXref "MESH:D011984" ; oboInOwl:hasExactSynonym "receptor cell" ; a owl:Class ; rdfs:label "sensory receptor cell" ; rdfs:subClassOf obo:CL_0000003 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_0000199 obo:IAO_0000115 "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." ; oboInOwl:hasRelatedSynonym "mechanoreceptor" ; a owl:Class ; rdfs:label "mechanoreceptor cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050974 ] ) ] . obo:CL_0000200 a owl:Class ; rdfs:label "touch receptor cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050976 ] ) ] . obo:CL_0000206 obo:IAO_0000115 "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." ; a owl:Class ; rdfs:label "chemoreceptor cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000197 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050907 ] ) ] . obo:CL_0000207 oboInOwl:hasDbXref "BTO:0004185", "FMA:67860", "MESH:D018034", "Wikipedia:Olfactory_receptor_neuron" ; oboInOwl:hasExactSynonym "Schultze's cell", "odorant receptor cell", "olfactory receptor neuron", "olfactory sensory neuron" ; a owl:Class ; rdfs:label "olfactory receptor cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005725 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ) ] . obo:CL_0000209 obo:IAO_0000115 "A specialized cell involved in gustatory sensory perception." ; oboInOwl:hasDbXref "FMA:67910" ; oboInOwl:hasExactSynonym "taste bud cell" ; a owl:Class ; rdfs:label "taste receptor cell" ; rdfs:subClassOf obo:CL_0000098, obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000206 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050912 ] ) ] . obo:CL_0000210 obo:IAO_0000115 "A cell specialized to detect and transduce light." ; oboInOwl:hasDbXref "BTO:0001060", "CALOHA:TS-0868", "FMA:86740" ; a owl:Class ; rdfs:label "photoreceptor cell" ; rdfs:subClassOf obo:CL_0000006 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050962 ] ) ] . obo:CL_0000211 obo:IAO_0000115 "A cell whose function is determined by the generation or the reception of an electric signal." ; a owl:Class ; rdfs:label "electrically active cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000213 obo:IAO_0000115 "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." ; oboInOwl:hasExactSynonym "boundary cell" ; a owl:Class ; rdfs:label "lining cell" ; rdfs:subClassOf obo:CL_0000215 . obo:CL_0000214 obo:IAO_0000115 "A cell located in the synovial joint." ; oboInOwl:hasDbXref "CALOHA:TS-0995" ; oboInOwl:hasExactSynonym "synoviocyte" ; a owl:Class ; rdfs:label "synovial cell" ; rdfs:subClassOf obo:CL_0000213, obo:CL_0002078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002217 ] . obo:CL_0000215 obo:IAO_0000115 "A cell whose primary function is to prevent the transport of stuff across compartments." ; a owl:Class ; rdfs:label "barrier cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000216 obo:IAO_0000115 "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." ; oboInOwl:hasDbXref "BTO:0001238", "CALOHA:TS-0922", "FMA:72298", "VHOG:0001348" ; a owl:Class ; rdfs:label "Sertoli cell" ; rdfs:subClassOf obo:CL_0000215, obo:CL_0000511, obo:CL_0000630, obo:CL_0002625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:CL_0000219 obo:IAO_0000115 "A cell that moves by its own activities." ; a owl:Class ; rdfs:label "motile cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:CL_0000221 obo:IAO_0000115 "A cell of the outer of the three germ layers of the embryo." ; oboInOwl:hasDbXref "FMA:72549" ; oboInOwl:hasExactSynonym "ectoderm cell" ; a owl:Class ; rdfs:label "ectodermal cell" ; rdfs:subClassOf obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ] . obo:CL_0000222 obo:IAO_0000115 "A cell of the middle germ layer of the embryo." ; oboInOwl:hasDbXref "FMA:72554" ; oboInOwl:hasExactSynonym "mesoblast", "mesoderm cell" ; a owl:Class ; rdfs:label "mesodermal cell" ; rdfs:subClassOf obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 ] . obo:CL_0000223 obo:IAO_0000115 "A cell of the inner of the three germ layers of the embryo." ; oboInOwl:hasDbXref "FMA:72555" ; oboInOwl:hasExactSynonym "endoderm cell" ; a owl:Class ; rdfs:label "endodermal cell" ; rdfs:subClassOf obo:CL_0002321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000925 ] . obo:CL_0000225 obo:IAO_0000115 "A cell that lacks a nucleus." ; oboInOwl:hasDbXref "FMA:68647" ; oboInOwl:hasExactSynonym "non-nucleated cell" ; a owl:Class ; rdfs:label "anucleate cell" ; owl:disjointWith obo:CL_0002242 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0000226 obo:IAO_0000115 "A cell with a single nucleus." ; a owl:Class ; rdfs:label "single nucleate cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000227 a owl:Class ; rdfs:label "binucleate cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001406 ] ) ] . obo:CL_0000228 obo:IAO_0000115 "A cell with more than one nucleus." ; oboInOwl:hasDbXref "AEO:0000203", "WBbt:0008074" ; oboInOwl:hasExactSynonym "syncitium", "syncytial cell", "syncytium" ; a owl:Class ; rdfs:label "multinucleate cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000232 obo:IAO_0000115 "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." ; oboInOwl:hasDbXref "BTO:0000424", "CALOHA:TS-0290", "FMA:81100" ; oboInOwl:hasExactSynonym "RBC", "red blood cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "erythrocyte" ; rdfs:subClassOf obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000558 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005840 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015671 ] ) ] . obo:CL_0000233 obo:IAO_0000115 "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." ; oboInOwl:hasDbXref "BTO:0000132", "CALOHA:TS-0803", "FMA:62851" ; oboInOwl:hasExactSynonym "anucleate thrombocyte", "blood platelet", "enucleate thrombocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF." ; rdfs:label "platelet" ; rdfs:subClassOf obo:CL_0000081, obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000556 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007596 ] . obo:CL_0000234 obo:IAO_0000115 "Any cell capable of ingesting particulate matter via phagocytosis." ; oboInOwl:hasDbXref "BTO:0001044", "FMA:83806", "MESH:D010586" ; a owl:Class ; rdfs:label "phagocyte" ; rdfs:subClassOf obo:CL_0000219, obo:CL_0000325, obo:CL_0000473, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] ) ] . obo:CL_0000235 obo:IAO_0000115 "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ; oboInOwl:hasDbXref "BTO:0000801", "CALOHA:TS-0587", "FMA:63261", "FMA:83585", "MESH:D008264" ; oboInOwl:hasExactSynonym "histiocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid." ; rdfs:label "macrophage" ; rdfs:subClassOf obo:CL_0000766, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0031268 ] ) ] . obo:CL_0000236 obo:IAO_0000115 "A lymphocyte of B lineage that is capable of B cell mediated immunity." ; oboInOwl:hasDbXref "BTO:0000776", "CALOHA:TS-0068", "FMA:62869", "MESH:D001402", "VHOG:0001480" ; oboInOwl:hasExactSynonym "B lymphocyte", "B-cell", "B-lymphocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "B cell" ; rdfs:subClassOf obo:CL_0000945, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000826 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000945 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:CL_0000237 a owl:Class ; rdfs:label "keratinizing barrier epithelial cell" ; rdfs:subClassOf obo:CL_0000240, obo:CL_0000311, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000114 ] . obo:CL_0000240 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stratified squamous epithelial cell" ; rdfs:subClassOf obo:CL_0000076, obo:CL_0000079 . obo:CL_0000242 obo:IAO_0000115 "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." ; oboInOwl:hasDbXref "FMA:70548" ; oboInOwl:hasExactSynonym "Merkel's cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "Merkel cell" ; rdfs:subClassOf obo:CL_0000123, obo:CL_0000312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002025 ] . obo:CL_0000255 oboInOwl:hasDbXref "MESH:D005057" ; a owl:Class ; rdfs:label "eukaryotic cell" . obo:CL_0000287 oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "eye photoreceptor cell" ; rdfs:subClassOf obo:CL_0000210 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] . obo:CL_0000293 obo:IAO_0000115 "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." ; a owl:Class ; rdfs:label "structural cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000295 obo:IAO_0000115 "A peptide hormone secreting cell that produces growth hormone, somatotropin." ; oboInOwl:hasExactSynonym "growth hormone secreting cell", "somatotrophin secreting cell" ; a owl:Class ; rdfs:label "somatotropin secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030252 ] ) ] . obo:CL_0000300 obo:IAO_0000115 "A mature sexual reproductive cell having a single set of unpaired chromosomes." ; oboInOwl:hasDbXref "CALOHA:TS-0395", "FBbt:00005412", "FMA:18649" ; oboInOwl:hasExactSynonym "haploid nucleated cell" ; oboInOwl:hasRelatedSynonym "haploid germ cell" ; a owl:Class ; rdfs:label "gamete" ; rdfs:subClassOf obo:CL_0000586 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:CL_0000306 oboInOwl:hasExactSynonym "lens cell" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "crystallin accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000307 obo:IAO_0000115 "An epithelial cell found in the trachea." ; oboInOwl:hasDbXref "FMA:74793" ; oboInOwl:hasExactSynonym "tracheocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'" ; rdfs:label "tracheal epithelial cell" ; rdfs:subClassOf obo:CL_0002202, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_0000311 a owl:Class ; rdfs:label "keratin accumulating cell" ; rdfs:subClassOf obo:CL_0000325 . obo:CL_0000312 obo:IAO_0000115 "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." ; oboInOwl:hasDbXref "BTO:0000667", "CALOHA:TS-0500", "FMA:62879" ; oboInOwl:hasExactSynonym "keratinized cell of epidermis", "malpighian cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive." ; rdfs:label "keratinocyte" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002775 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002776 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0090023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_0000313 obo:IAO_0000115 "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." ; oboInOwl:hasDbXref "BTO:0003687", "FMA:62511" ; oboInOwl:hasExactSynonym "serous cell" ; a owl:Class ; rdfs:label "serous secreting cell" ; rdfs:subClassOf obo:CL_0000159 . obo:CL_0000314 a owl:Class ; rdfs:label "milk secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000317 obo:IAO_0000115 "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." ; oboInOwl:hasExactSynonym "sebocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sebum secreting cell" ; rdfs:subClassOf obo:CL_0000151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:CL_0000319 oboInOwl:hasDbXref "BTO:0003689" ; oboInOwl:hasExactSynonym "mucous cell" ; a owl:Class ; rdfs:label "mucus secreting cell" ; rdfs:subClassOf obo:CL_0000159, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:CL_0000322 obo:IAO_0000115 "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." ; oboInOwl:hasDbXref "BTO:0000395", "CALOHA:TS-2168", "FMA:62499" ; oboInOwl:hasExactSynonym "alveolar epithelial cell", "pneumonocyte" ; a owl:Class ; rdfs:label "pneumocyte" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004821 ] . obo:CL_0000325 obo:IAO_0000115 "A cell that is specialised to accumulate a particular substance(s)." ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "stuff accumulating cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000327 a owl:Class ; rdfs:label "extracellular matrix secreting cell" ; rdfs:subClassOf obo:CL_0000499 . obo:CL_0000329 a owl:Class ; rdfs:label "oxygen accumulating cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015671 ] ) ] . obo:CL_0000333 obo:IAO_0000115 "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." ; oboInOwl:hasDbXref "FMA:86667" ; a owl:Class ; rdfs:label "migratory neural crest cell" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000219, obo:CL_0011012, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007004 ] . obo:CL_0000335 obo:IAO_0000115 "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." ; a owl:Class ; rdfs:label "mesenchyme condensation cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0008019 . obo:CL_0000336 obo:IAO_0000115 "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." ; oboInOwl:hasDbXref "FMA:69262" ; oboInOwl:hasExactSynonym "medullary chromaffin cell of adrenal gland" ; a owl:Class ; rdfs:label "adrenal medulla chromaffin cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000166, obo:CL_0000457, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] ) ] . obo:CL_0000339 obo:IAO_0000115 "An early neural cell developing from the early ependymal cell of the neural tube." ; oboInOwl:hasDbXref "FMA:70564" ; oboInOwl:hasExactSynonym "spongioblast" ; a owl:Class ; rdfs:label "glioblast (sensu Vertebrata)" ; rdfs:subClassOf obo:CL_0000030, obo:CL_0000123 . obo:CL_0000347 obo:IAO_0000115 "A cell of the sclera of the eye." ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "scleral cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] . obo:CL_0000348 obo:IAO_0000115 "A structural cell that is part of optic choroid." ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "choroidal cell of the eye" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] . obo:CL_0000349 oboInOwl:inSubset cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "extraembryonic cell" ; rdfs:subClassOf obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000478 ] ) ] . obo:CL_0000351 obo:IAO_0000115 "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." ; oboInOwl:hasDbXref "FMA:83028" ; oboInOwl:hasExactSynonym "trophoblastic cell" ; a owl:Class ; rdfs:label "trophoblast cell" ; rdfs:subClassOf obo:CL_0000349, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000358 ] . obo:CL_0000352 obo:IAO_0000115 "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." ; a owl:Class ; rdfs:label "epiblast cell" ; rdfs:subClassOf obo:CL_0000052 . obo:CL_0000353 obo:IAO_0000115 "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." ; oboInOwl:hasDbXref "BTO:0001473", "FMA:72551" ; oboInOwl:hasExactSynonym "blastomere" ; a owl:Class ; rdfs:label "blastoderm cell" ; rdfs:subClassOf obo:CL_0000007 . obo:CL_0000354 oboInOwl:hasDbXref "ncithesaurus:Blastemal_Cell" ; oboInOwl:hasExactSynonym "blastema cell" ; a owl:Class ; rdfs:label "blastemal cell" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0000355 obo:IAO_0000115 "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." ; oboInOwl:hasDbXref "FMA:86767" ; a owl:Class ; rdfs:comment "Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo." ; rdfs:label "multi-potent skeletal muscle stem cell" ; rdfs:subClassOf obo:CL_0000048 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:CL_0000357 a owl:Class ; rdfs:label "stratified epithelial stem cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0000358 obo:IAO_0000115 "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." ; a owl:Class ; rdfs:label "sphincter associated smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004590 ] ) ] . obo:CL_0000359 obo:IAO_0000115 "A smooth muscle cell associated with the vasculature." ; oboInOwl:hasExactSynonym "VSMC", "vascular smooth muscle cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vascular associated smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002049 ] ) ] . obo:CL_0000362 obo:IAO_0000115 "An epithelial cell of the integument (the outer layer of an organism)." ; oboInOwl:hasDbXref "BTO:0001470", "CALOHA:TS-0283", "FMA:62411", "MESH:D000078404" ; oboInOwl:hasExactSynonym "cell of epidermis" ; oboInOwl:hasNarrowSynonym "epithelial cell of skin" ; a owl:Class ; rdfs:label "epidermal cell" ; rdfs:subClassOf obo:CL_0002159, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007376 ] ) ] . obo:CL_0000365 obo:IAO_0000115 "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." ; oboInOwl:hasBroadSynonym "zygote" ; oboInOwl:hasDbXref "BTO:0000854", "EHDAA2:0004546", "FMA:72395" ; a owl:Class ; rdfs:label "animal zygote" ; rdfs:subClassOf obo:CL_0000007, obo:CL_0010017 . obo:CL_0000377 a owl:Class ; rdfs:label "tracheoblast" ; rdfs:subClassOf obo:CL_0000069 . obo:CL_0000393 obo:IAO_0000115 "A cell whose function is determined by its response to an electric signal." ; a owl:Class ; rdfs:label "electrically responsive cell" ; rdfs:subClassOf obo:CL_0000211 . obo:CL_0000397 a owl:Class ; rdfs:label "ganglion interneuron" ; rdfs:subClassOf obo:CL_0000099 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000045 ] ) ] . obo:CL_0000402 obo:IAO_0000115 "An interneuron that has its cell body in a central nervous system." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system." ; rdfs:label "CNS interneuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0000404 obo:IAO_0000115 "A cell that initiates an electrical signal and passes that signal to another cell." ; a owl:Class ; rdfs:label "electrically signaling cell" ; rdfs:subClassOf obo:CL_0000211 . obo:CL_0000408 oboInOwl:hasDbXref "BTO:0001277", "CALOHA:TS-0949" ; a owl:Class ; rdfs:label "male gamete" ; rdfs:subClassOf obo:CL_0000015, obo:CL_0000300, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:CL_0000412 obo:IAO_0000115 "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." ; a owl:Class ; rdfs:label "polyploid cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000413 obo:IAO_0000115 "A cell whose nucleus contains a single haploid genome." ; a owl:Class ; rdfs:label "haploid cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] ) ] . obo:CL_0000417 a owl:Class ; rdfs:label "endopolyploid cell" ; rdfs:subClassOf obo:CL_0000412 . obo:CL_0000432 obo:IAO_0000115 "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." ; oboInOwl:hasDbXref "FMA:62877" ; oboInOwl:hasExactSynonym "reticulum cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "reticular cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; rdfs:subClassOf obo:CL_0000057 . obo:CL_0000438 obo:IAO_0000115 "A peptide hormone secreting cell pituitary that produces luteinizing hormone." ; a owl:Class ; rdfs:label "luteinizing hormone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032275 ] ) ] . obo:CL_0000439 obo:IAO_0000115 "A peptide hormone cell that secretes prolactin." ; a owl:Class ; rdfs:label "prolactin secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070459 ] ) ] . obo:CL_0000440 obo:IAO_0000115 "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." ; oboInOwl:hasDbXref "BTO:0002277" ; oboInOwl:hasExactSynonym "melanotrope", "melanotroph" ; a owl:Class ; rdfs:label "melanocyte stimulating hormone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036160 ] ) ] . obo:CL_0000443 a owl:Class ; rdfs:label "calcitonin secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:CL_0000446 obo:IAO_0000115 "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." ; oboInOwl:hasDbXref "BTO:0004712", "CALOHA:TS-2140", "FMA:69078" ; oboInOwl:hasExactSynonym "parathyroid chief cell", "parathyroid gland chief cell", "parathyroid hormone secreting cell", "principal cell of parathyroid gland" ; a owl:Class ; rdfs:label "chief cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000167, obo:CL_0002260 . obo:CL_0000447 a owl:Class ; rdfs:label "carbohydrate secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000451 obo:IAO_0000115 "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." ; oboInOwl:hasDbXref "BTO:0002042", "CALOHA:TS-0194", "FMA:83036", "MESH:D003713" ; oboInOwl:hasRelatedSynonym "interdigitating cell", "veiled cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "dendritic cell" ; rdfs:subClassOf obo:CL_0000738 ; owl:disjointWith obo:CL_0000542 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045580 ] ) ] . obo:CL_0000453 obo:IAO_0000115 "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." ; oboInOwl:hasDbXref "BTO:0000705", "CALOHA:TS-2375", "FMA:63072", "MESH:D007801" ; oboInOwl:hasExactSynonym "LC" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis." ; rdfs:label "Langerhans cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000763 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002828 ] ) ] . obo:CL_0000454 obo:IAO_0000115 "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." ; oboInOwl:hasExactSynonym "adrenaline secreting cell", "epinephrin secreting cell" ; a owl:Class ; rdfs:label "epinephrine secreting cell" ; rdfs:subClassOf obo:CL_0000457 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:CL_0000456 a owl:Class ; rdfs:label "mineralocorticoid secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035931 ] ) ] . obo:CL_0000457 a owl:Class ; rdfs:label "biogenic amine secreting cell" ; rdfs:subClassOf obo:CL_0000151 . obo:CL_0000458 obo:IAO_0000115 "A cell type that secretes 5-Hydroxytryptamine (serotonin)." ; oboInOwl:hasExactSynonym "5-HT secreting cell", "5-Hydroxytryptamine secreting cell" ; a owl:Class ; rdfs:label "serotonin secreting cell" ; rdfs:subClassOf obo:CL_0000457 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820 ] ) ] . obo:CL_0000459 obo:IAO_0000115 "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." ; oboInOwl:hasExactSynonym "noradrenaline secreting cell", "norepinephrin secreting cell", "norepinephrine secreting cell" ; a owl:Class ; rdfs:label "noradrenergic cell" ; rdfs:subClassOf obo:CL_0000457 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:CL_0000467 obo:IAO_0000115 "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." ; oboInOwl:hasExactSynonym "ACTH secreting cell", "adrenocorticotrophic hormone secreting cell", "corticotrophin hormone secreting cell", "corticotropin hormone secreting cell", "corticotropin secreting cell" ; a owl:Class ; rdfs:label "adrenocorticotropic hormone secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0051458 ] ) ] . obo:CL_0000473 obo:IAO_0000115 "A cell whose primary function is to protect the organism." ; a owl:Class ; rdfs:label "defensive cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000484 obo:IAO_0000115 "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." ; oboInOwl:hasExactSynonym "MC(TC)", "MCTC", "TC mast cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype." ; rdfs:label "connective tissue type mast cell" ; rdfs:subClassOf obo:CL_0000097 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] ) ] . obo:CL_0000488 obo:IAO_0000115 "A photoreceptor cell that detects visible light." ; a owl:Class ; rdfs:label "visible light photoreceptor cell" ; rdfs:subClassOf obo:CL_0000210 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009584 ] ) ] . obo:CL_0000492 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." ; oboInOwl:hasDbXref "CALOHA:TS-1146", "FMA:70572" ; oboInOwl:hasExactSynonym "CD4-positive T-helper cell", "CD4-positive helper T lymphocyte", "CD4-positive helper T-cell", "CD4-positive helper T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive helper T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:CL_0000498 obo:IAO_0000115 "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." ; oboInOwl:hasDbXref "FMA:84776" ; a owl:Class ; rdfs:label "inhibitory interneuron" ; rdfs:subClassOf obo:CL_0000099 . obo:CL_0000499 obo:IAO_0000115 "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." ; oboInOwl:hasDbXref "BTO:0002064", "FMA:83624" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell" ; rdfs:subClassOf obo:CL_0002320, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000502 obo:IAO_0000115 "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." ; oboInOwl:hasDbXref "FMA:62935" ; oboInOwl:hasExactSynonym "D cell" ; a owl:Class ; rdfs:label "type D enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070253 ] . obo:CL_0000506 obo:IAO_0000115 "An endorphine cell that secretes enkephalin." ; a owl:Class ; rdfs:label "enkephalin secreting cell" ; rdfs:subClassOf obo:CL_0000507 . obo:CL_0000507 obo:IAO_0000115 "A peptide hormone secreting cell that secretes endorphin." ; a owl:Class ; rdfs:label "endorphin secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000508 obo:IAO_0000115 "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." ; oboInOwl:hasDbXref "BTO:0004108", "FMA:67609" ; oboInOwl:hasExactSynonym "G cell" ; a owl:Class ; rdfs:label "type G enteroendocrine cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000506, obo:CL_0000509, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004997 ] . obo:CL_0000509 obo:IAO_0000115 "A peptide hormone secreting cell that secretes gastrin." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "gastrin secreting cell" ; rdfs:subClassOf obo:CL_0000167 . obo:CL_0000511 obo:IAO_0000115 "A peptide hormone secreting cell that secretes androgen binding protein." ; a owl:Class ; rdfs:label "androgen binding protein secreting cell" ; rdfs:subClassOf obo:CL_0000154 . obo:CL_0000513 obo:IAO_0000115 "A precursor cell destined to differentiate into cardiac muscle cell." ; oboInOwl:hasDbXref "FMA:84797" ; oboInOwl:hasExactSynonym "cardiac muscle progenitor cell", "cardiomyocyte progenitor cell" ; a owl:Class ; rdfs:label "cardiac muscle myoblast" ; rdfs:subClassOf obo:CL_0000056 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000746 ] ) ] . obo:CL_0000514 obo:IAO_0000115 "A precursor cell destined to differentiate into smooth muscle myocytes." ; oboInOwl:hasDbXref "FMA:84798" ; oboInOwl:hasExactSynonym "myoblast, smooth muscle" ; oboInOwl:hasRelatedSynonym "satellite cell" ; a owl:Class ; rdfs:label "smooth muscle myoblast" ; rdfs:subClassOf obo:CL_0000056, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000192 ] ) ] . obo:CL_0000515 obo:IAO_0000115 "A myoblast that differentiates into skeletal muscle fibers." ; oboInOwl:hasDbXref "FMA:84799" ; oboInOwl:hasExactSynonym "skeletal myoblast" ; a owl:Class ; rdfs:label "skeletal muscle myoblast" ; rdfs:subClassOf obo:CL_0000056, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0000525 obo:IAO_0000115 "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." ; oboInOwl:hasDbXref "FMA:83043" ; oboInOwl:hasExactSynonym "plasmidotrophoblast", "syncytial trophoblast", "syntrophoblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "syncytiotrophoblast cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) ] . obo:CL_0000526 obo:IAO_0000115 "A neuron which conveys sensory information centrally from the periphery." ; oboInOwl:hasDbXref "FMA:87653" ; oboInOwl:hasExactSynonym "input neuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "afferent neuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0000527 obo:IAO_0000115 "A neuron which sends impulses peripherally to activate muscles or secretory cells." ; oboInOwl:hasExactSynonym "output neuron" ; a owl:Class ; rdfs:label "efferent neuron" ; rdfs:subClassOf obo:CL_0000540 . obo:CL_0000540 obo:IAO_0000115 "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ; oboInOwl:hasDbXref "BTO:0000938", "CALOHA:TS-0683", "FBbt:00005106", "FMA:54527", "VHOG:0001483", "WBbt:0003679" ; oboInOwl:hasExactSynonym "nerve cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma." ; rdfs:label "neuron" ; rdfs:subClassOf obo:CL_0000393, obo:CL_0000404, obo:CL_0002319, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019226 ] . obo:CL_0000541 obo:IAO_0000115 "A cell that originates from the neural crest and differentiates into a pigment cell." ; oboInOwl:hasDbXref "BTO:0003217", "FMA:83377" ; a owl:Class ; rdfs:comment "Derived from UBERON:0002342 neural crest." ; rdfs:label "melanoblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0000542 obo:IAO_0000115 "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ; oboInOwl:hasDbXref "BTO:0000775", "CALOHA:TS-0583", "FMA:62863", "MESH:D008214", "VHOG:0001535" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)" ; rdfs:label "lymphocyte" ; rdfs:subClassOf obo:CL_0000738, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:disjointWith obo:CL_0000766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017500 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017505 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000547 obo:IAO_0000115 "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83518" ; oboInOwl:hasExactSynonym "rubriblast" ; oboInOwl:hasRelatedSynonym "pronormoblast" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "proerythroblast" ; rdfs:subClassOf obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000038 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017505 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0000548 obo:IAO_0000115 "A native cell that is part of some Metazoa." ; oboInOwl:hasExactSynonym "metazoan cell" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "animal cell" ; rdfs:subClassOf obo:CL_0000255 . obo:CL_0000549 obo:IAO_0000115 "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83505" ; oboInOwl:hasExactSynonym "basophilic normoblast", "early erythroblast", "early normoblast", "prorubricyte" ; a owl:Class ; rdfs:label "basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000547 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0000550 obo:IAO_0000115 "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." ; oboInOwl:hasDbXref "FMA:83506" ; oboInOwl:hasExactSynonym "intermediate erythroblast", "intermediate normoblast", "polychromatic erythroblast", "polychromatic normoblast", "polychromatophilic normoblast", "rubricyte" ; a owl:Class ; rdfs:label "polychromatophilic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000549 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017504 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000792 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0000552 obo:IAO_0000115 "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." ; oboInOwl:hasDbXref "FMA:84646" ; oboInOwl:hasExactSynonym "acidophilic erythroblast", "eosinophilic erythroblast", "late erythoblast", "orthochromatic normoblast", "pyknotic eto enrythroblast" ; a owl:Class ; rdfs:label "orthochromatic erythroblast" ; rdfs:subClassOf obo:CL_0000765, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000550 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0030263 ] ) ] . obo:CL_0000553 obo:IAO_0000115 "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." ; oboInOwl:hasDbXref "BTO:0001164", "CALOHA:TS-0610", "FMA:84235", "MESH:D055016" ; oboInOwl:hasExactSynonym "CFU-Meg", "Meg-CFC", "MkP", "colony-forming unit-megakaryocyte", "megacaryoblast", "megacaryocyte progenitor cell", "megakaryoblast", "megakaryocytic progenitor cell" ; oboInOwl:hasRelatedSynonym "promegacaryocyte", "promegakaryocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ; rdfs:label "megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:CL_0000555 a owl:Class ; rdfs:label "neuronal brush cell" ; rdfs:subClassOf obo:CL_0000117 . obo:CL_0000556 obo:IAO_0000115 "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." ; oboInOwl:hasDbXref "BTO:0000843", "CALOHA:TS-0611", "FMA:83555" ; oboInOwl:hasExactSynonym "megacaryocyte", "megalocaryocyte", "megalokaryocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Megakaryocytes are reportedly CD181-positive and CD182-positive." ; rdfs:label "megakaryocyte" ; rdfs:subClassOf obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001393 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000553 ] ; owl:disjointWith obo:CL_0000764 . obo:CL_0000557 obo:IAO_0000115 "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." ; oboInOwl:hasBroadSynonym "CFU-C , Colony forming unit in culture" ; oboInOwl:hasExactSynonym "CFU-GM", "GMP", "colony forming unit granulocyte macrophage", "granulocyte-macrophage progenitor", "granulocyte/monocyte precursor", "granulocyte/monocyte progenitor" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ; rdfs:label "granulocyte monocyte progenitor cell" ; rdfs:subClassOf obo:CL_0002032, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:CL_0000558 obo:IAO_0000115 "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." ; oboInOwl:hasDbXref "BTO:0001173", "CALOHA:TS-0864", "MESH:D012156" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "reticulocyte" ; rdfs:subClassOf obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0071971 ] ) ] . obo:CL_0000559 obo:IAO_0000115 "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." ; oboInOwl:hasDbXref "BTO:0004657", "FMA:83551" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ; rdfs:label "promonocyte" ; rdfs:subClassOf obo:CL_0002194, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000040 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002194 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0000561 obo:IAO_0000115 "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." ; oboInOwl:hasDbXref "BTO:0004044", "FMA:67766" ; oboInOwl:hasExactSynonym "amacrine neuron" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "amacrine cell" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0000740 ] . obo:CL_0000562 obo:IAO_0000115 "An erythrocyte having a nucleus." ; oboInOwl:hasBroadSynonym "RBC", "red blood cell" ; a owl:Class ; rdfs:label "nucleate erythrocyte" ; rdfs:subClassOf obo:CL_0000232, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000232 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] . obo:CL_0000566 obo:IAO_0000115 "A mesenchymal stem cell capable of developing into blood vessel endothelium." ; oboInOwl:hasExactSynonym "angioblast", "chondroplast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ; rdfs:label "angioblastic mesenchymal cell" ; rdfs:subClassOf obo:CL_0000134, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001444 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002112 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016043 ] ) ] . obo:CL_0000568 obo:IAO_0000115 "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." ; oboInOwl:hasDbXref "BTO:0003866", "FMA:83114" ; oboInOwl:hasExactSynonym "APUD cell" ; a owl:Class ; rdfs:label "amine precursor uptake and decarboxylation cell" ; rdfs:subClassOf obo:CL_0000165 . obo:CL_0000569 obo:IAO_0000115 "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." ; a owl:Class ; rdfs:label "cardiac mesenchymal cell" ; rdfs:subClassOf obo:CL_2000073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008019 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0002494 ] ) ] . obo:CL_0000570 obo:IAO_0000115 "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." ; oboInOwl:hasDbXref "FMA:68653", "SCTID:176770005" ; oboInOwl:hasExactSynonym "C cell", "C cell of thyroid gland", "clear cell of thyroid gland", "parafollicular cell of thyroid gland", "thyroid parafollicular cell" ; a owl:Class ; rdfs:label "parafollicular cell" ; rdfs:subClassOf obo:CL_0000443, obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001747 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000710 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:CL_0000573 obo:IAO_0000115 "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." ; oboInOwl:hasDbXref "BTO:0001036", "CALOHA:TS-0866", "FMA:67748" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal cone cell" ; rdfs:subClassOf obo:CL_0010009, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002672 ] . obo:CL_0000575 obo:IAO_0000115 "An epithelial cell of the cornea." ; oboInOwl:hasDbXref "BTO:0004298", "CALOHA:TS-0173", "FMA:70551" ; oboInOwl:hasExactSynonym "epithelial cell of cornea" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "corneal epithelial cell" ; rdfs:subClassOf obo:CL_0002159, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001772 ] ) ] . obo:CL_0000576 obo:IAO_0000115 "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ; oboInOwl:hasDbXref "BTO:0000876", "CALOHA:TS-0638", "FMA:62864" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ; rdfs:label "monocyte" ; rdfs:subClassOf obo:CL_0000766, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000559 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0000586 obo:IAO_0000115 "The reproductive cell in multicellular organisms." ; oboInOwl:hasDbXref "BTO:0000535", "NCIT:C12597", "VHOG:0001534", "WBbt:0006796" ; a owl:Class ; rdfs:label "germ cell" ; rdfs:subClassOf obo:CL_0000039, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0009566 ] . obo:CL_0000593 obo:IAO_0000115 "A steroid hormone secreting cell that secretes androgen." ; a owl:Class ; rdfs:label "androgen secreting cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035935 ] ) ] . obo:CL_0000595 obo:IAO_0000115 "An erythrocyte lacking a nucleus." ; oboInOwl:hasBroadSynonym "RBC", "red blood cell" ; a owl:Class ; rdfs:label "enucleate erythrocyte" ; rdfs:subClassOf obo:CL_0000232, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002422 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000232 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0000604 obo:IAO_0000115 "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." ; oboInOwl:hasDbXref "BTO:0001024", "CALOHA:TS-0870", "FMA:67747" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal rod cell" ; rdfs:subClassOf obo:CL_0010009, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002672 ] . obo:CL_0000613 obo:IAO_0000115 "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." ; oboInOwl:hasExactSynonym "BaP" ; oboInOwl:hasRelatedSynonym "CFU-Bas", "basophilic stem cell", "colony forming unit basophil" ; a owl:Class ; rdfs:comment "BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf)." ; rdfs:label "basophil progenitor cell" ; rdfs:subClassOf obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000016401 ] ) ] . obo:CL_0000617 obo:IAO_0000115 "A neuron that uses GABA as a vesicular neurotransmitter" ; oboInOwl:hasDbXref "FBbt:00007228", "FMA:84788", "MESH:D059330", "WBbt:0005190" ; oboInOwl:hasExactSynonym "GABA-ergic neuron" ; a owl:Class ; rdfs:label "GABAergic neuron" ; rdfs:subClassOf obo:CL_0000540 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_0000622 obo:IAO_0000115 "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." ; oboInOwl:hasDbXref "FMA:83625", "MESH:D061354" ; oboInOwl:hasExactSynonym "acinic cell", "acinous cell" ; a owl:Class ; rdfs:label "acinar cell" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009842 ] . obo:CL_0000623 obo:IAO_0000115 "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." ; oboInOwl:hasBroadSynonym "large granular lymphocyte", "null cell" ; oboInOwl:hasDbXref "BTO:0000914", "BTO:0004716", "CALOHA:TS-0664", "FMA:63147", "FMA:83601", "MESH:D007694", "VHOG:0001697" ; oboInOwl:hasExactSynonym "NK cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "natural killer cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000825 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001067 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050776 ] ) ] . obo:CL_0000624 obo:IAO_0000115 "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta T lymphocyte", "CD4-positive, alpha-beta T-cell", "CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000791 ; owl:disjointWith obo:CL_0000625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0000625 obo:IAO_0000115 "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta T lymphocyte", "CD8-positive, alpha-beta T-cell", "CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000791 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000791 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000626 obo:IAO_0000115 "Granule cell that is part of the olfactory bulb." ; a owl:Class ; rdfs:label "olfactory granule cell" ; rdfs:subClassOf obo:CL_0000120 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] . obo:CL_0000630 obo:IAO_0000115 "A cell whose primary function is to support other cell types." ; oboInOwl:hasDbXref "BTO:0002315" ; oboInOwl:hasExactSynonym "supportive cell" ; a owl:Class ; rdfs:label "supporting cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000632 obo:IAO_0000115 "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." ; oboInOwl:hasDbXref "BTO:0002741", "CALOHA:TS-0452", "FMA:67763" ; oboInOwl:hasExactSynonym "Ito cell", "hepatic perisinusoidal cell", "perisinusoidal cell" ; oboInOwl:hasRelatedSynonym "fat-storing cell", "lipocyte", "vitamin A-storing cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen." ; rdfs:label "hepatic stellate cell" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0000327, obo:CL_0002320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000007939 ] ) ] . obo:CL_0000636 obo:IAO_0000115 "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." ; oboInOwl:hasDbXref "BTO:0003064" ; oboInOwl:hasExactSynonym "Muller glia", "Müller cell" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "Mueller cell" ; rdfs:subClassOf obo:CL_0000681, obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:CL_0000637 obo:IAO_0000115 "A cell that stains readily in the anterior pituitary gland." ; oboInOwl:hasDbXref "FMA:83089" ; a owl:Class ; rdfs:label "chromophil cell of anterior pituitary gland" ; rdfs:subClassOf obo:CL_0000150, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002196 ] ) ] . obo:CL_0000638 obo:IAO_0000115 "An acidophilic chromophil cell that of the anterior pituitary gland." ; oboInOwl:hasDbXref "FMA:83093" ; oboInOwl:hasExactSynonym "acidophil cell of pars anterior of adenohypophysis", "acidophil of pars anterior of adenohypophysis", "acidophil of pars distalis of adenohypophysis", "pituitary alpha cell" ; a owl:Class ; rdfs:label "acidophil cell of pars distalis of adenohypophysis" ; rdfs:subClassOf obo:CL_0000637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006964 ] . obo:CL_0000642 obo:IAO_0000115 "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." ; a owl:Class ; rdfs:label "folliculostellate cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000548, obo:CL_0000630 . obo:CL_0000646 obo:IAO_0000115 "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." ; oboInOwl:hasDbXref "BTO:0000939", "FMA:62516" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell" ; rdfs:subClassOf obo:CL_0000036 . obo:CL_0000649 obo:IAO_0000115 "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." ; oboInOwl:hasDbXref "FMA:69059" ; oboInOwl:hasExactSynonym "prickle cell of epidermis" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "prickle cell" ; rdfs:subClassOf obo:CL_0000312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002026 ] . obo:CL_0000650 obo:IAO_0000115 "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." ; oboInOwl:hasDbXref "BTO:0000853", "CALOHA:TS-0617", "FMA:70972", "MESH:D050527" ; oboInOwl:hasExactSynonym "kidney mesangial cell" ; a owl:Class ; rdfs:comment "Do all of these cells really develop from some mesenchymal stem cell?" ; rdfs:label "mesangial cell" ; rdfs:subClassOf obo:CL_0000669, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000134 ] . obo:CL_0000652 obo:IAO_0000115 "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." ; oboInOwl:hasDbXref "BTO:0001068", "FMA:83417" ; a owl:Class ; rdfs:label "pinealocyte" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000710, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001905 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030187 ] . obo:CL_0000654 obo:IAO_0000115 "A primary oocyte is an oocyte that has not completed female meosis I." ; oboInOwl:hasDbXref "BTO:0000512", "FMA:18645" ; oboInOwl:hasRelatedSynonym "primary oogonium" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "primary oocyte" ; rdfs:subClassOf obo:CL_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000023 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:CL_0000655 obo:IAO_0000115 "A secondary oocyte is an oocyte that has not completed meiosis II." ; oboInOwl:hasDbXref "BTO:0003094", "FMA:18646" ; oboInOwl:hasRelatedSynonym "primary oogonium" ; a owl:Class ; rdfs:label "secondary oocyte" ; rdfs:subClassOf obo:CL_0000023, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000654 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000023 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0007147 ] ) ] . obo:CL_0000656 obo:IAO_0000115 "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." ; oboInOwl:hasDbXref "BTO:0001115", "CALOHA:TS-2194", "FMA:72292" ; a owl:Class ; rdfs:label "primary spermatocyte" ; rdfs:subClassOf obo:CL_0000017, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000017 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007140 ] ) ] . obo:CL_0000657 obo:IAO_0000115 "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." ; oboInOwl:hasDbXref "BTO:0000709", "CALOHA:TS-2195", "FBbt:00004941", "FMA:72293" ; a owl:Class ; rdfs:label "secondary spermatocyte" ; rdfs:subClassOf obo:CL_0000017, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000656 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000017 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007142 ] ) ] . obo:CL_0000666 oboInOwl:hasExactSynonym "window cell" ; a owl:Class ; rdfs:label "fenestrated cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 . obo:CL_0000667 obo:IAO_0000115 "An extracellular matrix secreting cell that secretes collagen." ; a owl:Class ; rdfs:label "collagen secreting cell" ; rdfs:subClassOf obo:CL_0000327 . obo:CL_0000669 obo:IAO_0000115 "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." ; oboInOwl:hasDbXref "BTO:0002441", "FMA:63174" ; oboInOwl:hasExactSynonym "ARC", "adventitial reticular cell", "cell of Rouget", "pericyte cell", "pericyte of Rouget" ; oboInOwl:hasRelatedSynonym "adventitial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A." ; rdfs:label "pericyte" ; rdfs:subClassOf obo:CL_0000183, obo:CL_0000630, obo:CL_0002320, obo:CL_0008034 . obo:CL_0000670 obo:IAO_0000115 "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." ; oboInOwl:hasDbXref "FMA:70567" ; oboInOwl:hasExactSynonym "gonocyte", "primitive germ cell" ; a owl:Class ; rdfs:label "primordial germ cell" ; rdfs:subClassOf obo:CL_0000039, obo:CL_0000219, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000039 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:CL_0000679 obo:IAO_0000115 "A neuron that is capable of some neurotansmission by glutamate secretion." ; oboInOwl:hasDbXref "FBbt:00100291", "WBbt:0006829" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "glutamatergic neuron" ; rdfs:subClassOf obo:CL_0000540 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:CL_0000680 obo:IAO_0000115 "A non-terminally differentiated cell that is capable of developing into a muscle cell." ; a owl:Class ; rdfs:label "muscle precursor cell" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011115 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000187 ] ) ] . obo:CL_0000681 obo:IAO_0000115 "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." ; oboInOwl:hasNarrowSynonym "forebrain radial glial cell" ; a owl:Class ; rdfs:comment """Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life.""" ; rdfs:label "radial glial cell" ; rdfs:subClassOf obo:CL_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000710 ] . obo:CL_0000696 obo:IAO_0000115 "A cell that stores and secretes pancreatic polypeptide hormone." ; oboInOwl:hasDbXref "FMA:62938", "FMA:83409" ; oboInOwl:hasExactSynonym "type F enteroendocrine cell" ; a owl:Class ; rdfs:label "PP cell" ; rdfs:subClassOf obo:CL_0000164, obo:CL_0000167 . obo:CL_0000710 obo:IAO_0000115 "Epithelial cells derived from neural plate and neural crest." ; oboInOwl:hasBroadSynonym "neuroepithelial cell" ; oboInOwl:hasDbXref "BTO:0004301", "FMA:70557" ; a owl:Class ; rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098)." ; rdfs:label "neurecto-epithelial cell" ; rdfs:subClassOf obo:CL_0000075 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002077 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ) ] . obo:CL_0000712 a owl:Class ; rdfs:label "stratum granulosum cell" ; rdfs:subClassOf obo:CL_0000362, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002069 ] ) ] . obo:CL_0000723 obo:IAO_0000115 "A stem cell that can give rise to cell types of the body other than those of the germ-line." ; oboInOwl:hasDbXref "CALOHA:TS-2086", "FMA:63368", "MESH:D053687" ; a owl:Class ; rdfs:label "somatic stem cell" ; rdfs:subClassOf obo:CL_0000034, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048103 ] ) ] . obo:CL_0000737 obo:IAO_0000115 "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." ; oboInOwl:hasDbXref "BTO:0002916", "CALOHA:TS-2157", "FMA:86936" ; a owl:Class ; rdfs:label "striated muscle cell" ; rdfs:subClassOf obo:CL_0000187 ; owl:disjointWith obo:CL_0008000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001410 ] ) ] . obo:CL_0000738 obo:IAO_0000115 "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ; oboInOwl:hasDbXref "BTO:0000751", "CALOHA:TS-0549", "FMA:62852", "MESH:D007962", "NCIT:C12529" ; oboInOwl:hasExactSynonym "leucocyte", "white blood cell" ; oboInOwl:hasRelatedSynonym "immune cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "leukocyte" ; rdfs:subClassOf obo:CL_0000988, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001667 ] ) ] . obo:CL_0000740 obo:IAO_0000115 "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." ; oboInOwl:hasDbXref "BTO:0001800", "FMA:67765", "MESH:D012165" ; oboInOwl:hasExactSynonym "RGC", "gangliocyte", "ganglion cell of retina" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal ganglion cell" ; rdfs:subClassOf obo:CL_0000117, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:CL_0000745 obo:IAO_0000115 "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." ; oboInOwl:hasDbXref "BTO:0004120" ; oboInOwl:hasExactSynonym "horizontal cell" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retina horizontal cell" ; rdfs:subClassOf obo:CL_0000099, [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0003902 ] . obo:CL_0000746 obo:IAO_0000115 "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." ; oboInOwl:hasAlternativeId "FMA:83808" ; oboInOwl:hasBroadSynonym "cardiocyte" ; oboInOwl:hasDbXref "BTO:0001539", "CALOHA:TS-0115", "FMA:14067", "MESH:D032383" ; oboInOwl:hasExactSynonym "cardiac muscle fiber", "cardiac myocyte", "cardiomyocyte", "heart muscle cell" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ; rdfs:label "cardiac muscle cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000513 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007100 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0060047 ] ) ] . obo:CL_0000748 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal bipolar neuron" ; rdfs:subClassOf obo:CL_0009004, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0061535 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098976 ] ) ] ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007601 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000103 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_0000752 obo:IAO_0000115 "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." ; a owl:Class ; rdfs:label "cone retinal bipolar cell" ; rdfs:subClassOf obo:CL_0000748 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000748 [ a owl:Restriction ; owl:onProperty obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000573 ] ) ] . obo:CL_0000762 obo:IAO_0000115 "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals." ; rdfs:label "nucleated thrombocyte" ; rdfs:subClassOf obo:CL_0000763, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000828 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:CL_0000763 obo:IAO_0000115 "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." ; oboInOwl:hasDbXref "BTO:0001441", "CALOHA:TS-0647", "MESH:D022423" ; a owl:Class ; rdfs:label "myeloid cell" ; rdfs:subClassOf obo:CL_0000988 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ) ] . obo:CL_0000764 obo:IAO_0000115 "A immature or mature cell in the lineage leading to and including erythrocytes." ; oboInOwl:hasDbXref "CALOHA:TS-0290", "FMA:62845", "FMA:83516" ; oboInOwl:hasExactSynonym "erythropoietic cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ; rdfs:label "erythroid lineage cell" ; rdfs:subClassOf obo:CL_0000763 . obo:CL_0000765 obo:IAO_0000115 "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." ; oboInOwl:hasDbXref "BTO:0001571", "CALOHA:TS-0289", "FMA:83504", "MESH:D004900" ; oboInOwl:hasExactSynonym "normoblast" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "erythroblast" ; rdfs:subClassOf obo:CL_0000764, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000547 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000764 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0005730 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:CL_0000766 obo:IAO_0000115 "A cell of the monocyte, granulocyte, or mast cell lineage." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "myeloid leukocyte" ; rdfs:subClassOf obo:CL_0000738 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000049 ] ) ] . obo:CL_0000767 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0000129", "CALOHA:TS-0073", "FMA:62862" ; oboInOwl:hasExactSynonym "basophilic leucocyte", "basophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive." ; rdfs:label "basophil" ; rdfs:subClassOf obo:CL_0000094 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001344 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001950 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000771 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." ; oboInOwl:hasBroadSynonym "polymorphonuclear leucocyte", "polymorphonuclear leukocyte" ; oboInOwl:hasDbXref "BTO:0000399", "CALOHA:TS-0279", "FMA:62861", "MESH:D004804" ; oboInOwl:hasExactSynonym "eosinocyte", "eosinophilic granulocyte", "eosinophilic leucocyte", "eosinophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte." ; rdfs:label "eosinophil" ; rdfs:subClassOf obo:CL_0000094 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] ) ] . obo:CL_0000775 obo:IAO_0000115 "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." ; oboInOwl:hasBroadSynonym "PMN", "poly", "polymorphonuclear leucocyte", "polymorphonuclear leukocyte", "polymorphonuclear neutrophil", "polynuclear neutrophilic leucocyte", "polynuclear neutrophilic leukocyte" ; oboInOwl:hasDbXref "BTO:0000130", "CALOHA:TS-0688", "FMA:62860", "MESH:D009504" ; oboInOwl:hasExactSynonym "neutrocyte", "neutrophil leucocyte", "neutrophil leukocyte", "neutrophilic leucocyte", "neutrophilic leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "neutrophil" ; rdfs:subClassOf obo:CL_0000094 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0000782 obo:IAO_0000115 "A dendritic cell of the myeloid lineage." ; oboInOwl:hasBroadSynonym "interdigitating cell", "veiled cell" ; oboInOwl:hasDbXref "BTO:0004721" ; oboInOwl:hasExactSynonym "CD11c+CD123- DC", "mDC" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ; rdfs:label "myeloid dendritic cell" ; rdfs:subClassOf obo:CL_0000990 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000763 ] ) ] . obo:CL_0000785 obo:IAO_0000115 "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." ; oboInOwl:hasExactSynonym "mature B lymphocyte", "mature B-cell", "mature B-lymphocyte" ; a owl:Class ; rdfs:comment "Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive." ; rdfs:label "mature B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000818 ] ; owl:disjointWith obo:CL_0000816, obo:CL_0000817, obo:CL_0000818 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002335 ] ) ] . obo:CL_0000787 obo:IAO_0000115 "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." ; oboInOwl:hasExactSynonym "memory B lymphocyte", "memory B-cell", "memory B-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive." ; rdfs:label "memory B cell" ; rdfs:subClassOf obo:CL_0000785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002344 ] ) ] . obo:CL_0000788 obo:IAO_0000115 "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "naive B lymphocyte", "naive B-cell", "naive B-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive." ; rdfs:label "naive B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000818 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002344 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000789 obo:IAO_0000115 "A T cell that expresses an alpha-beta T cell receptor complex." ; oboInOwl:hasExactSynonym "alpha-beta T lymphocyte", "alpha-beta T-cell", "alpha-beta T-lymphocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000084 ; owl:disjointWith obo:CL_0000798 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0000790 obo:IAO_0000115 "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." ; oboInOwl:hasExactSynonym "immature alpha-beta T lymphocyte", "immature alpha-beta T-cell", "immature alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:label "immature alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000789 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000791 obo:IAO_0000115 "A alpha-beta T cell that has a mature phenotype." ; oboInOwl:hasExactSynonym "mature alpha-beta T lymphocyte", "mature alpha-beta T-cell", "mature alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:label "mature alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000789, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000789 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000792 obo:IAO_0000115 "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; oboInOwl:hasBroadSynonym "Treg", "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasExactSynonym "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell", "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype." ; rdfs:label "CD4-positive, CD25-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000624 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001869 ] ) ] . obo:CL_0000795 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; oboInOwl:hasBroadSynonym "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasExactSynonym "CD8+ T(reg)", "CD8+ Treg", "CD8+ regulatory T cell", "CD8-positive T(reg)", "CD8-positive Treg", "CD8-positive, alpha-beta Treg", "CD8-positive, alpha-beta regulatory T lymphocyte", "CD8-positive, alpha-beta regulatory T-cell", "CD8-positive, alpha-beta regulatory T-lymphocyte" ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta regulatory T cell" ; rdfs:subClassOf obo:CL_0000625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000798 obo:IAO_0000115 "A T cell that expresses a gamma-delta T cell receptor complex." ; oboInOwl:hasExactSynonym "gamma-delta T lymphocyte", "gamma-delta T-cell", "gamma-delta T-lymphocyte", "gammadelta T cell" ; oboInOwl:hasRelatedSynonym "gd T cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ; rdfs:label "gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000084 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042106 ] ) ] . obo:CL_0000799 obo:IAO_0000115 "A gamma-delta T cell that has an immature phenotype." ; oboInOwl:hasExactSynonym "immature gamma-delta T lymphocyte", "immature gamma-delta T-cell", "immature gamma-delta T-lymphocyte" ; a owl:Class ; rdfs:comment "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ; rdfs:label "immature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000798, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0042492 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000800 obo:IAO_0000115 "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." ; oboInOwl:hasExactSynonym "mature gamma-delta T lymphocyte", "mature gamma-delta T-cell", "mature gamma-delta T-lymphocyte" ; a owl:Class ; rdfs:label "mature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000798, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000799 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000805 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." ; oboInOwl:hasExactSynonym "ISP", "T.ISP.th", "immature single positive T cell", "immature single positive T lymphocyte", "immature single positive T-lymphocyte" ; a owl:Class ; rdfs:comment "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages." ; rdfs:label "immature single positive thymocyte" ; rdfs:subClassOf obo:CL_0000893, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000808 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0000806 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." ; oboInOwl:hasExactSynonym "DN2 alpha-beta immature T lymphocyte", "DN2 alpha-beta immature T-cell", "DN2 alpha-beta immature T-lymphocyte", "DN2 cell", "DN2 immature T cell", "TN2 cell", "TN2 thymocyte", "double negative 2", "preT.DN2.Th" ; a owl:Class ; rdfs:comment "Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2 thymocyte" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000894 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000807 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." ; oboInOwl:hasBroadSynonym "early cortical thymocyte" ; oboInOwl:hasExactSynonym "DN3 alpha-beta immature T lymphocyte", "DN3 alpha-beta immature T-cell", "DN3 alpha-beta immature T-lymphocyte", "DN3 cell", "DN3 immature T cell", "TN3 cell", "TN3 thymocyte", "double negative 3", "preT.DN3.Th" ; a owl:Class ; rdfs:comment "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN3 thymocyte" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000806 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000808 obo:IAO_0000115 "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." ; oboInOwl:hasBroadSynonym "early cortical thymocyte" ; oboInOwl:hasExactSynonym "DN4 alpha-beta immature T lymphocyte", "DN4 alpha-beta immature T-lymphocyte", "DN4 cell", "DN4 immature T cell", "DN4 immature T-cell", "T.DN4.th", "double negative 4" ; a owl:Class ; rdfs:comment "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN4 thymocyte" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0043384 ] ) ] . obo:CL_0000809 obo:IAO_0000115 "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." ; oboInOwl:hasBroadSynonym "late cortical thymocyte" ; oboInOwl:hasExactSynonym "DP cell", "DP thymocyte", "double-positive, alpha-beta immature T lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Thymocytes of this stage are undergoing positive and negative selection." ; rdfs:label "double-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000805 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000810 obo:IAO_0000115 "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta immature T lymphocyte", "CD4-positive, alpha-beta immature T-cell", "CD4-positive, alpha-beta immature T-lymphocyte", "SP CD4 cell" ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0000811 obo:IAO_0000115 "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta immature T lymphocyte", "CD8-positive, alpha-beta immature T-cell", "CD8-positive, alpha-beta immature T-lymphocyte", "SP CD8 cell" ; oboInOwl:hasRelatedSynonym "CD8-positive, alpha-beta immature T cell" ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta thymocyte" ; rdfs:subClassOf obo:CL_0000790, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0000813 obo:IAO_0000115 "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." ; oboInOwl:hasDbXref "BTO:0003435" ; oboInOwl:hasExactSynonym "memory T lymphocyte", "memory T-cell", "memory T-lymphocyte" ; a owl:Class ; rdfs:label "memory T cell" ; rdfs:subClassOf obo:CL_0002419 ; owl:disjointWith obo:CL_0000898 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000815 obo:IAO_0000115 "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." ; oboInOwl:hasBroadSynonym "suppressor T cell", "suppressor T lymphocyte", "suppressor T-cell", "suppressor T-lymphocyte" ; oboInOwl:hasDbXref "BTO:0004520", "FMA:84070", "MESH:D050378" ; oboInOwl:hasExactSynonym "Treg", "regulatory T lymphocyte", "regulatory T-cell", "regulatory T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta." ; rdfs:label "regulatory T cell" ; rdfs:subClassOf obo:CL_0002419 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000816 obo:IAO_0000115 "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." ; oboInOwl:hasExactSynonym "immature B lymphocyte", "immature B-cell", "immature B-lymphocyte", "newly formed B cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive." ; rdfs:label "immature B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045190 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000817 obo:IAO_0000115 "A precursor B cell is a B cell with the phenotype CD10-positive." ; oboInOwl:hasDbXref "BTO:0001133", "CALOHA:TS-0819" ; oboInOwl:hasRelatedSynonym "pre-B cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "precursor B cell" ; rdfs:subClassOf obo:CL_0001201 ; owl:disjointWith obo:CL_0000826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0000818 obo:IAO_0000115 "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." ; oboInOwl:hasExactSynonym "transitional B cell", "transitional stage B lymphocyte", "transitional stage B-cell", "transitional stage B-lymphocyte" ; oboInOwl:hasNarrowSynonym "T1 B cell", "T2 B cell", "T3 B cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'." ; rdfs:label "transitional stage B cell" ; rdfs:subClassOf obo:CL_0001201, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000816 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001201 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0002335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0000819 obo:IAO_0000115 "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." ; oboInOwl:hasExactSynonym "B-1 B lymphocyte", "B-1 B-cell", "B-1 B-lymphocyte", "B-1 cell", "B1 B cell", "B1 B lymphocyte", "B1 B-cell", "B1 B-lymphocyte", "B1 cell" ; a owl:Class ; rdfs:comment "There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low." ; rdfs:label "B-1 B cell" ; rdfs:subClassOf obo:CL_0000785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000820 obo:IAO_0000115 "A B-1 B cell that has the phenotype CD5-positive." ; oboInOwl:hasExactSynonym "B-1a B lymphocyte", "B-1a B-cell", "B-1a B-lymphocyte", "B1a B cell", "B1a B lymphocyte", "B1a B-cell", "B1a B-lymphocyte", "B1a cell", "CD5(+) B1 cell", "CD5+ B1 cell", "CD5-positive B1 cell" ; a owl:Class ; rdfs:label "B-1a B cell" ; rdfs:subClassOf obo:CL_0000819 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000819 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0000821 obo:IAO_0000115 "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." ; oboInOwl:hasExactSynonym "B-1b B lymphocyte", "B-1b B-cell", "B-1b B-lymphocyte", "B1b B cell", "B1b B lymphocyte", "B1b B-cell", "B1b B-lymphocyte", "B1b cell" ; a owl:Class ; rdfs:label "B-1b B cell" ; rdfs:subClassOf obo:CL_0000819 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000819 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0000822 obo:IAO_0000115 "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." ; oboInOwl:hasExactSynonym "B-2 B lymphocyte", "B-2 B-cell", "B-2 B-lymphocyte", "B2 B cell", "B2 B lymphocyte", "B2 B-cell", "B2 B-lymphocyte", "B2 cell" ; oboInOwl:hasRelatedSynonym "B-0 B cell" ; a owl:Class ; rdfs:comment "B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive." ; rdfs:label "B-2 B cell" ; rdfs:subClassOf obo:CL_0000785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000823 obo:IAO_0000115 "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." ; oboInOwl:hasExactSynonym "immature NK cell" ; oboInOwl:hasRelatedSynonym "p-NK" ; a owl:Class ; rdfs:comment "In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules." ; rdfs:label "immature natural killer cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000937 ] ; owl:disjointWith obo:CL_0000937 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0000825 obo:IAO_0000115 "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." ; oboInOwl:hasExactSynonym "NKP", "natural killer cell progenitor", "pro-natural killer cell" ; oboInOwl:hasRelatedSynonym "null cell", "preNK cell" ; a owl:Class ; rdfs:comment "Most markers only described for human pro NK cells." ; rdfs:label "pro-NK cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0000826 obo:IAO_0000115 "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." ; oboInOwl:hasBroadSynonym "pre-pro B cell" ; oboInOwl:hasDbXref "BTO:0003104" ; oboInOwl:hasExactSynonym "pro-B lymphocyte", "pro-B-cell", "pro-B-lymphocyte", "progenitor B cell", "progenitor B lymphocyte", "progenitor B-cell", "progenitor B-lymphocyte" ; oboInOwl:hasRelatedSynonym "pre-B cell (Philadelphia nomenclature)" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative." ; rdfs:label "pro-B cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001903 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0033152 ] ) ] . obo:CL_0000827 obo:IAO_0000115 "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." ; oboInOwl:hasExactSynonym "pro-T lymphocyte", "progenitor T cell" ; oboInOwl:hasNarrowSynonym "DN1 cell", "DN1 thymocyte", "TN1 cell" ; a owl:Class ; rdfs:label "pro-T cell" ; rdfs:subClassOf obo:CL_0000838, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000838 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000828 obo:IAO_0000115 "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." ; a owl:Class ; rdfs:comment "Note that this is a non-mammalian cell type." ; rdfs:label "thromboblast" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002574 ] ) ] . obo:CL_0000829 obo:IAO_0000115 "A myeloblast committed to the basophil lineage." ; a owl:Class ; rdfs:label "basophilic myeloblast" ; rdfs:subClassOf obo:CL_0000835, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000613 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000835 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:CL_0000831 obo:IAO_0000115 "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." ; oboInOwl:hasExactSynonym "MCP" ; oboInOwl:hasRelatedSynonym "CFU-MC", "CFU-Mast", "colony forming unit mast cell" ; a owl:Class ; rdfs:comment "MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa." ; rdfs:label "mast cell progenitor" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000016401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0000835 obo:IAO_0000115 "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." ; oboInOwl:hasDbXref "BTO:0000187", "FMA:83524" ; a owl:Class ; rdfs:label "myeloblast" ; rdfs:subClassOf obo:CL_0002191, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002191 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017503 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0017505 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0000791 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0042582 ] ) ] . obo:CL_0000837 obo:IAO_0000115 "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." ; oboInOwl:hasDbXref "BTO:0000725", "CALOHA:TS-0448" ; oboInOwl:hasExactSynonym "MPP", "hemopoietic progenitor cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers differ between mouse and human." ; rdfs:label "hematopoietic multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000988, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000037 ] ; owl:disjointWith obo:CL_0002032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0000838 obo:IAO_0000115 "A progenitor cell restricted to the lymphoid lineage." ; oboInOwl:hasBroadSynonym "lymphoid progenitor cell" ; oboInOwl:hasDbXref "BTO:0004731", "CALOHA:TS-2025", "FMA:70338" ; a owl:Class ; rdfs:comment "Note that this is a class of cell types, not an identified single cell type." ; rdfs:label "lymphoid lineage restricted progenitor cell" ; rdfs:subClassOf obo:CL_0002031 ; owl:disjointWith obo:CL_0000839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000839 obo:IAO_0000115 "A progenitor cell restricted to the myeloid lineage." ; oboInOwl:hasBroadSynonym "myeloid progenitor cell" ; oboInOwl:hasDbXref "BTO:0004730", "CALOHA:TS-2099", "FMA:70339" ; a owl:Class ; rdfs:comment "Note that this is a class of cell types, not an identified single cell type." ; rdfs:label "myeloid lineage restricted progenitor cell" ; rdfs:subClassOf obo:CL_0002031 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030099 ] ) ] . obo:CL_0000842 obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form." ; oboInOwl:hasDbXref "BTO:0000878", "CALOHA:TS-0768", "FMA:86713" ; oboInOwl:hasExactSynonym "mononuclear leukocyte" ; oboInOwl:hasNarrowSynonym "peripheral blood mononuclear cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "mononuclear cell" ; rdfs:subClassOf obo:CL_0000738 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) ] . obo:CL_0000843 obo:IAO_0000115 "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." ; oboInOwl:hasExactSynonym "Fo B cell", "Fo B-cell", "follicular B lymphocyte", "follicular B-cell", "follicular B-lymphocyte" ; a owl:Class ; rdfs:comment "Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ; rdfs:label "follicular B cell" ; rdfs:subClassOf obo:CL_0000785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ) ] . obo:CL_0000844 obo:IAO_0000115 "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." ; oboInOwl:hasExactSynonym "GC B cell", "GC B lymphocyte", "GC B-cell", "GC B-lymphocyte", "germinal center B lymphocyte", "germinal center B-cell", "germinal center B-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive." ; rdfs:label "germinal center B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000843 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001745 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0000845 obo:IAO_0000115 "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." ; oboInOwl:hasBroadSynonym "MZ B cell", "MZ B lymphocyte", "MZ B-cell", "MZ B-lymphocyte", "marginal zone B cell", "marginal zone B lymphocyte", "marginal zone B-cell", "marginal zone B-lymphocyte" ; oboInOwl:hasExactSynonym "B cell of marginal zone of spleen", "marginal zone of spleen B cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive." ; rdfs:label "marginal zone B cell of spleen" ; rdfs:subClassOf obo:CL_0000785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001251 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0042742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000847 obo:IAO_0000115 "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." ; oboInOwl:hasExactSynonym "ciliated olfactory sensory neuron", "ciliated sensory neuron" ; a owl:Class ; rdfs:label "ciliated olfactory receptor neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000207 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) ] . obo:CL_0000860 obo:IAO_0000115 "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." ; oboInOwl:hasExactSynonym "inflammatory monocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Markers: CCR2+CXCCR1 (human, mouse, rat)." ; rdfs:label "classical monocyte" ; rdfs:subClassOf obo:CL_0000576 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002548 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001199 ] ) ] . obo:CL_0000861 obo:IAO_0000115 "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." ; oboInOwl:hasDbXref "FMA:84643", "FMA:84645" ; oboInOwl:hasExactSynonym "free macrophage", "wandering histiocyte" ; a owl:Class ; rdfs:comment "Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response)." ; rdfs:label "elicited macrophage" ; rdfs:subClassOf obo:CL_0000235, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000860 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002064 ] ) ] . obo:CL_0000862 obo:IAO_0000115 "A macrophage that suppresses immune responses." ; a owl:Class ; rdfs:comment "Markers: May express: IL10, TGFbeta." ; rdfs:label "suppressor macrophage" ; rdfs:subClassOf obo:CL_0000861 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000861 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000864 obo:IAO_0000115 "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ; oboInOwl:hasDbXref "FMA:84642", "FMA:84644" ; oboInOwl:hasExactSynonym "fixed macrophage", "resting histiocyte" ; a owl:Class ; rdfs:label "tissue-resident macrophage" ; rdfs:subClassOf obo:CL_0000235 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] . obo:CL_0000878 obo:IAO_0000115 "A tissue-resident macrophage found in the central nervous system." ; oboInOwl:hasExactSynonym "CNS macrophage" ; a owl:Class ; rdfs:label "central nervous system macrophage" ; rdfs:subClassOf obo:CL_0000864 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0000881 obo:IAO_0000115 "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." ; a owl:Class ; rdfs:comment "Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+." ; rdfs:label "perivascular macrophage" ; rdfs:subClassOf obo:CL_0000878 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000878 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001925 ] ) ] . obo:CL_0000889 obo:IAO_0000115 "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis." ; rdfs:label "myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000766 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0000891 obo:IAO_0000115 "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." ; oboInOwl:hasDbXref "BTO:0003872", "FMA:83586", "MESH:D005487" ; a owl:Class ; rdfs:label "foam cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0000893 obo:IAO_0000115 "An immature T cell located in the thymus." ; oboInOwl:hasBroadSynonym "immature T cell", "immature T lymphocyte", "immature T-cell", "immature T-lymphocyte" ; oboInOwl:hasDbXref "BTO:0001372", "CALOHA:TS-1042", "FMA:72202", "MESH:D060168", "XAO:0003159" ; oboInOwl:hasExactSynonym "thymic lymphocyte" ; a owl:Class ; rdfs:label "thymocyte" ; rdfs:subClassOf obo:CL_0002420 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000894 obo:IAO_0000115 "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." ; oboInOwl:hasExactSynonym "DN1 thymic pro-T lymphocyte", "DN1 thymic pro-T-cell", "DN1 thymic pro-T-lymphocyte", "DN1 thymic progenitor T cell", "DN1 thymocyte", "double negative 1", "preT.DN1.Th" ; a owl:Class ; rdfs:label "DN1 thymic pro-T cell" ; rdfs:subClassOf obo:CL_0000827, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002425 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000827 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000895 obo:IAO_0000115 "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." ; oboInOwl:hasBroadSynonym "naive CD4+ T cell" ; oboInOwl:hasExactSynonym "T.4Nve.Sp", "Th0", "naive thymus-derived CD4-positive, alpha-beta T lymphocyte", "naive thymus-derived CD4-positive, alpha-beta T-cell", "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells." ; rdfs:label "naive thymus-derived CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002436 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000896 obo:IAO_0000115 "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." ; oboInOwl:hasExactSynonym "activated CD4-positive, alpha-beta T lymphocyte", "activated CD4-positive, alpha-beta T-cell", "activated CD4-positive, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:label "activated CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000895 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000897 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." ; dcterms:contributor ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta memory T lymphocyte", "CD4-positive, alpha-beta memory T-cell", "CD4-positive, alpha-beta memory T-lymphocyte" ; oboInOwl:hasRelatedSynonym "T4.Mem.Sp" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta memory T cell" ; rdfs:subClassOf obo:CL_0000624 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000898 obo:IAO_0000115 "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." ; oboInOwl:hasExactSynonym "naive T lymphocyte", "naive T-cell", "naive T-lymphocyte" ; a owl:Class ; rdfs:label "naive T cell" ; rdfs:subClassOf obo:CL_0002419 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000900 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." ; oboInOwl:hasBroadSynonym "naive CD8+ T cell" ; oboInOwl:hasExactSynonym "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte", "naive thymus-dervied CD8-positive, alpha-beta T-cell", "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:hasNarrowSynonym "T.8Nve.Sp" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells." ; rdfs:label "naive thymus-derived CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002437 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001307 ] ) ] . obo:CL_0000904 obo:IAO_0000115 "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "central memory CD4+ T cell" ; oboInOwl:hasExactSynonym "central CD4-positive, alpha-beta memory T cell", "central CD4-positive, alpha-beta memory T lymphocyte", "central CD4-positive, alpha-beta memory T-cell", "central CD4-positive, alpha-beta memory T-lymphocyte", "central memory CD4-positive, alpha-beta T lymphocyte", "central memory CD4-positive, alpha-beta T-cell", "central memory CD4-positive, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells." ; rdfs:label "central memory CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001204 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001204 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ) ] . obo:CL_0000905 obo:IAO_0000115 "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "effector memory CD4+ T cell" ; oboInOwl:hasExactSynonym "effector CD4-positive, alpha-beta memory T cell", "effector CD4-positive, alpha-beta memory T lymphocyte", "effector CD4-positive, alpha-beta memory T-cell", "effector CD4-positive, alpha-beta memory T-lymphocyte", "effector memory CD4-positive, alpha-beta T lymphocyte", "effector memory CD4-positive, alpha-beta T-cell", "effector memory CD4-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells." ; rdfs:label "effector memory CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001204 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001204 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000906 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." ; oboInOwl:hasExactSynonym "activated CD8-positive, alpha-beta T lymphocyte", "activated CD8-positive, alpha-beta T-cell", "activated CD8-positive, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:label "activated CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000900 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000907 obo:IAO_0000115 "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "central memory CD8+ T cell" ; oboInOwl:hasExactSynonym "central CD8-positive, alpha-beta memory T cell", "central CD8-positive, alpha-beta memory T lymphocyte", "central CD8-positive, alpha-beta memory T-cell", "central CD8-positive, alpha-beta memory T-lymphocyte", "central memory CD8-positive, alpha-beta T lymphocyte", "central memory CD8-positive, alpha-beta T-cell", "central memory CD8-positive, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells." ; rdfs:label "central memory CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001203 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001203 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001203 ] ) ] . obo:CL_0000908 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte", "CD8-positive, alpha-beta cytokine secreting effector T-cell", "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta cytokine secreting effector T cell" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0000909 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." ; dcterms:contributor ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta memory T lymphocyte", "CD8-positive, alpha-beta memory T-cell", "CD8-positive, alpha-beta memory T-lymphocyte" ; oboInOwl:hasRelatedSynonym "T.8Mem.Sp" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta memory T cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0000911 obo:IAO_0000115 "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." ; oboInOwl:hasExactSynonym "effector T lymphocyte", "effector T-cell", "effector T-lymphocyte" ; a owl:Class ; rdfs:label "effector T cell" ; rdfs:subClassOf obo:CL_0002419 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002419 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0045026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0000912 obo:IAO_0000115 "A effector T cell that provides help in the form of secreted cytokines to other immune cells." ; oboInOwl:hasDbXref "BTO:0002417", "MESH:D006377" ; oboInOwl:hasExactSynonym "T-helper cell", "helper T lymphocyte", "helper T-cell", "helper T-lymphocyte" ; a owl:Class ; rdfs:label "helper T cell" ; rdfs:subClassOf obo:CL_0000911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:CL_0000913 obo:IAO_0000115 "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; oboInOwl:hasBroadSynonym "effector memory CD8+ T cell" ; oboInOwl:hasExactSynonym "effector CD8-positive, alpha-beta memory T cell", "effector CD8-positive, alpha-beta memory T lymphocyte", "effector CD8-positive, alpha-beta memory T-cell", "effector CD8-positive, alpha-beta memory T-lymphocyte", "effector memory CD8-positive, alpha-beta T lymphocyte", "effector memory CD8-positive, alpha-beta T-cell", "effector memory CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells." ; rdfs:label "effector memory CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0001203 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001203 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] ) ] . obo:CL_0000936 obo:IAO_0000115 "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." ; oboInOwl:hasExactSynonym "ELP", "LMPP", "lymphoid-primed multipotent progenitor" ; oboInOwl:hasRelatedSynonym "GMLP" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative." ; rdfs:label "early lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002035 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:CL_0000937 obo:IAO_0000115 "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." ; oboInOwl:hasExactSynonym "pre-NK cell" ; a owl:Class ; rdfs:comment "These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high." ; rdfs:label "pre-natural killer cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0000941 obo:IAO_0000115 "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." ; a owl:Class ; rdfs:comment "In the mouse this cell expresses CD8-alpha-alpha." ; rdfs:label "thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000894 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] ) ] . obo:CL_0000945 obo:IAO_0000115 "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex)." ; rdfs:label "lymphocyte of B lineage" ; rdfs:subClassOf obo:CL_0000542, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000826 ] . obo:CL_0000946 obo:IAO_0000115 "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." ; a owl:Class ; rdfs:label "antibody secreting cell" ; rdfs:subClassOf obo:CL_0000945 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000945 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0042571 ] ) ] . obo:CL_0000948 obo:IAO_0000115 "A class switched memory B cell that expresses IgE on the cell surface." ; oboInOwl:hasExactSynonym "IgE memory B lymphocyte", "IgE memory B-cell", "IgE memory B-lymphocyte", "memory IgE B cell", "memory IgE B lymphocyte", "memory IgE B-cell", "memory IgE B-lymphocyte" ; a owl:Class ; rdfs:label "IgE memory B cell" ; rdfs:subClassOf obo:CL_0000972 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071742 ] ) ] . obo:CL_0000949 obo:IAO_0000115 "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." ; a owl:Class ; rdfs:label "IgD plasmablast" ; rdfs:subClassOf obo:CL_0000980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071739 ] ) ] . obo:CL_0000950 obo:IAO_0000115 "A plasmablast that secretes IgE." ; a owl:Class ; rdfs:label "IgE plasmablast" ; rdfs:subClassOf obo:CL_0000980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071743 ] ) ] . obo:CL_0000952 obo:IAO_0000115 "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." ; a owl:Class ; rdfs:label "preBCR-positive large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000957 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000957 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000953 obo:IAO_0000115 "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." ; a owl:Class ; rdfs:label "preBCR-negative large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000957 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000957 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000954 obo:IAO_0000115 "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." ; oboInOwl:hasExactSynonym "small pre-BII cell" ; a owl:Class ; rdfs:comment "Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "small pre-B-II cell" ; rdfs:subClassOf obo:CL_0000955 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000955 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0019815 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071708 ] ) ] . obo:CL_0000955 obo:IAO_0000115 "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." ; oboInOwl:hasDbXref "BTO:0001133", "CALOHA:TS-0819" ; oboInOwl:hasExactSynonym "pre-B-lymphocyte", "pre-BII cell" ; a owl:Class ; rdfs:comment "pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive." ; rdfs:label "pre-B-II cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000826 ] ; owl:disjointWith obo:CL_0000956 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0071707 ] ) ] . obo:CL_0000956 obo:IAO_0000115 "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." ; oboInOwl:hasExactSynonym "pre-BI cell" ; oboInOwl:hasRelatedSynonym "pro-B cell (Philadelphia nomenclature)" ; a owl:Class ; rdfs:comment "Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive." ; rdfs:label "pre-B-I cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000826 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000006611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0071707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001859 ] ) ] . obo:CL_0000957 obo:IAO_0000115 "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." ; oboInOwl:hasBroadSynonym "large pre-B cell" ; oboInOwl:hasExactSynonym "large pre-BII cell" ; a owl:Class ; rdfs:comment "Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ; rdfs:label "large pre-B-II cell" ; rdfs:subClassOf obo:CL_0000955 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000955 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:PR_000003460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0046651 ] ) ] . obo:CL_0000958 obo:IAO_0000115 "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." ; oboInOwl:hasExactSynonym "T1 B lymphocyte", "T1 B-cell", "T1 B-lymphocyte", "transitional stage 1 B cell" ; a owl:Class ; rdfs:comment "T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ; rdfs:label "T1 B cell" ; rdfs:subClassOf obo:CL_0000818 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0000959 obo:IAO_0000115 "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." ; oboInOwl:hasExactSynonym "T2 B lymphocyte", "T2 B-cell", "T2 B-lymphocyte", "transitional stage 2 B cell" ; a owl:Class ; rdfs:comment "T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ; rdfs:label "T2 B cell" ; rdfs:subClassOf obo:CL_0000818, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000958 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0000961 obo:IAO_0000115 "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." ; oboInOwl:hasExactSynonym "Bm1 B lymphocyte", "Bm1 B-cell", "Bm1 B-lymphocyte" ; a owl:Class ; rdfs:comment "These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm1 B cell" ; rdfs:subClassOf obo:CL_0000843, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000818 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000843 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0000962 obo:IAO_0000115 "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." ; oboInOwl:hasExactSynonym "Bm2 B lymphocyte", "Bm2 B-cell", "Bm2 B-lymphocyte" ; a owl:Class ; rdfs:comment "These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm2 B cell" ; rdfs:subClassOf obo:CL_0000843, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000961 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000843 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001880 ] ) ] . obo:CL_0000963 obo:IAO_0000115 "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." ; oboInOwl:hasExactSynonym "Bm3-delta B lymphocyte", "Bm3-delta B-cell", "Bm3-delta B-lymphocyte" ; a owl:Class ; rdfs:label "Bm3-delta B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000965 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0000964 obo:IAO_0000115 "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." ; oboInOwl:hasExactSynonym "Bm2' B lymphocyte", "Bm2' B-cell", "Bm2-prime B cell", "Bm2-prime B-lymphocyte" ; oboInOwl:hasRelatedSynonym "germinal center founder cell" ; a owl:Class ; rdfs:comment "Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ; rdfs:label "Bm2' B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000962 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002634 ] ) ] . obo:CL_0000965 obo:IAO_0000115 "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." ; oboInOwl:hasExactSynonym "Bm3 B lymphocyte", "Bm3 B-cell", "Bm3 B-lymphocyte" ; oboInOwl:hasRelatedSynonym "centroblast" ; a owl:Class ; rdfs:comment "Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive." ; rdfs:label "Bm3 B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000964 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0016446 ] ) ] . obo:CL_0000966 obo:IAO_0000115 "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." ; oboInOwl:hasExactSynonym "Bm4 B lymphocyte", "Bm4 B-cell", "Bm4 B-lymphocyte" ; oboInOwl:hasRelatedSynonym "centrocyte" ; a owl:Class ; rdfs:comment "Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive." ; rdfs:label "Bm4 B cell" ; rdfs:subClassOf obo:CL_0000844, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000963 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000003516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016446 ] ) ] . obo:CL_0000970 obo:IAO_0000115 "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." ; oboInOwl:hasBroadSynonym "IgD+ memory B cell" ; oboInOwl:hasExactSynonym "non-class-switched memory B cell", "unswitched memory B lymphocyte", "unswitched memory B-cell", "unswitched memory B-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ; rdfs:label "unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000787, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071742 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071745 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000971 obo:IAO_0000115 "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." ; oboInOwl:hasExactSynonym "IgM memory B lymphocyte", "IgM memory B-cell", "IgM memory B-lymphocyte", "memory IgM B cell", "memory IgM B lymphocyte", "memory IgM B-cell", "memory IgM B-lymphocyte" ; a owl:Class ; rdfs:comment "IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive." ; rdfs:label "IgM memory B cell" ; rdfs:subClassOf obo:CL_0000787 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] ) ] . obo:CL_0000972 obo:IAO_0000115 "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." ; oboInOwl:hasExactSynonym "class switched memory B lymphocyte", "class switched memory B-cell", "class switched memory B-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive." ; rdfs:label "class switched memory B cell" ; rdfs:subClassOf obo:CL_0000787, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045190 ] ) ] . obo:CL_0000973 obo:IAO_0000115 "A class switched memory B cell that expresses IgA." ; oboInOwl:hasExactSynonym "IgA memory B lymphocyte", "IgA memory B-cell", "IgA memory B-lymphocyte", "memory IgA B cell", "memory IgA B lymphocyte", "memory IgA B-cell", "memory IgA B-lymphocyte" ; a owl:Class ; rdfs:comment "IgA memory B cell are also reportedly RORalpha-positive." ; rdfs:label "IgA memory B cell" ; rdfs:subClassOf obo:CL_0000972 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071745 ] ) ] . obo:CL_0000979 obo:IAO_0000115 "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." ; oboInOwl:hasExactSynonym "IgG memory B lymphocyte", "IgG memory B-cell", "IgG memory B-lymphocyte", "memory IgG B cell", "memory IgG B lymphocyte", "memory IgG B-cell", "memory IgG B-lymphocyte" ; a owl:Class ; rdfs:label "IgG memory B cell" ; rdfs:subClassOf obo:CL_0000972 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0000980 obo:IAO_0000115 "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." ; oboInOwl:hasBroadSynonym "CD20-negative B cell" ; oboInOwl:hasDbXref "FMA:84371" ; oboInOwl:hasExactSynonym "CD27-positive, CD38-positive, CD20-negative B cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative." ; rdfs:label "plasmablast" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000785 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0042571 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000981 obo:IAO_0000115 "A memory B cell with the phenotype IgD-negative and CD27-negative." ; oboInOwl:hasExactSynonym "dn memory B cell", "dn memory B lymphocyte", "dn memory B-cell", "dn memory B-lymphocyte", "double negative memory B lymphocyte", "double negative memory B-cell", "double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "double negative memory B cell" ; rdfs:subClassOf obo:CL_0000787 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001963 ] ) ] . obo:CL_0000982 obo:IAO_0000115 "A plasmablast that secretes IgG." ; a owl:Class ; rdfs:label "IgG plasmablast" ; rdfs:subClassOf obo:CL_0000980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071736 ] ) ] . obo:CL_0000983 obo:IAO_0000115 "A plasmablast that secretes IgM." ; a owl:Class ; rdfs:label "IgM plasmablast" ; rdfs:subClassOf obo:CL_0000980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071754 ] ) ] . obo:CL_0000984 obo:IAO_0000115 "A plasmablast that secretes IgA." ; a owl:Class ; rdfs:label "IgA plasmablast" ; rdfs:subClassOf obo:CL_0000980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:GO_0071746 ] ) ] . obo:CL_0000988 obo:IAO_0000115 "A cell of a hematopoietic lineage." ; oboInOwl:hasDbXref "BTO:0000574", "CALOHA:TS-2017", "FMA:70366", "FMA:83598" ; oboInOwl:hasExactSynonym "haematopoietic cell", "haemopoietic cell", "hemopoietic cell" ; a owl:Class ; rdfs:label "hematopoietic cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 . obo:CL_0000990 obo:IAO_0000115 "Conventional dendritic cell is a dendritic cell that is CD11c-high." ; oboInOwl:hasBroadSynonym "interdigitating cell", "veiled cell" ; oboInOwl:hasDbXref "FMA:84191" ; oboInOwl:hasExactSynonym "DC1", "cDC", "dendritic reticular cell", "type 1 DC" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ; rdfs:label "conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001013 ] ) ] . obo:CL_0000995 oboInOwl:hasBroadSynonym "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" ; a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0001060 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001021 obo:CL_0001026 ) ] . obo:CL_0001008 obo:IAO_0000115 "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." ; oboInOwl:hasExactSynonym "LSK stem cell", "Sca1-positive hematopoietic stem cell" ; a owl:Class ; rdfs:comment "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ; rdfs:label "Kit and Sca1-positive hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037 ; owl:disjointWith obo:CL_0001024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002977 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0001012 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ; rdfs:label "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0001060 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0000557 obo:CL_0001027 ) ] . obo:CL_0001019 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ; rdfs:label "CD115-positive monocyte OR common dendritic progenitor" ; rdfs:subClassOf obo:CL_0002031 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001022 obo:CL_0001029 ) ] . obo:CL_0001021 obo:IAO_0000115 "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." ; oboInOwl:hasExactSynonym "CD10-positive common lymphocyte precursor", "CD10-positive common lymphocyte progenitor", "CD10-positive common lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000051, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002043 ] ; owl:disjointWith obo:CL_0001025 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001898 ] ) ] . obo:CL_0001022 obo:IAO_0000115 "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ; rdfs:label "CD115-positive monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] ) ] . obo:CL_0001023 obo:IAO_0000115 "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." ; oboInOwl:hasBroadSynonym "CD117-positive common myeloid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617)." ; rdfs:label "Kit-positive, CD34-positive common myeloid progenitor" ; rdfs:subClassOf obo:CL_0001059, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002035 ] ; owl:disjointWith obo:CL_0001026 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001059 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001481 ] ) ] . obo:CL_0001024 obo:IAO_0000115 "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." ; oboInOwl:hasDbXref "CALOHA:TS-0448", "FMA:86475" ; oboInOwl:hasExactSynonym "CD133-positive hematopoietic stem cell" ; a owl:Class ; rdfs:comment "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-negative hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001892 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001809 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001843 ] ) ] . obo:CL_0001025 obo:IAO_0000115 "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." ; oboInOwl:hasExactSynonym "CD217-positive common lymphocyte precursor", "CD217-positive common lymphocyte progenitor", "CD217-positive common lymphoid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, Sca1-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0000051, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0001026 obo:IAO_0000115 "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." ; oboInOwl:hasNarrowSynonym "CD71-positive common myeloid precursor" ; a owl:Class ; rdfs:comment "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ; rdfs:label "CD34-positive, CD38-positive common myeloid progenitor" ; rdfs:subClassOf obo:CL_0001059, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001059 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001865 ] ) ] . obo:CL_0001027 obo:IAO_0000115 "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." ; oboInOwl:hasExactSynonym "CD7-negative lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ; rdfs:label "CD7-negative lymphoid progenitor cell" ; rdfs:subClassOf obo:CL_0000051, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001021 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001836 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0001028 obo:IAO_0000115 "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." ; oboInOwl:hasExactSynonym "CD7-positive lymphoid precursor" ; a owl:Class ; rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ; rdfs:label "CD7-positive lymphoid progenitor cell" ; rdfs:subClassOf obo:CL_0000051, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001027 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000051 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001836 ] ) ] . obo:CL_0001029 obo:IAO_0000115 "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." ; oboInOwl:hasExactSynonym "CDP", "common dendritic precursor", "pro-DCs" ; a owl:Class ; rdfs:comment "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ; rdfs:label "common dendritic progenitor" ; rdfs:subClassOf obo:CL_0002031, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0001030 a owl:Class ; rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617)." ; rdfs:label "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor" ; rdfs:subClassOf obo:CL_0001060 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:CL_0001023 obo:CL_0001025 ) ] . obo:CL_0001031 obo:IAO_0000115 "Granule cell that is part of the cerebellum." ; oboInOwl:hasDbXref "BTO:0004278" ; a owl:Class ; rdfs:label "cerebellar granule cell" ; rdfs:subClassOf obo:CL_0000120 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:CL_0001032 obo:IAO_0000115 "Granule cell that is part of the cerebral cortex." ; a owl:Class ; rdfs:label "cortical granule cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0001033 obo:IAO_0000115 "Granule cell with a soma found in the hippocampus." ; a owl:Class ; rdfs:label "hippocampal granule cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000120 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_0001035 obo:IAO_0000115 "A connective tissue cell found in bone." ; dcterms:contributor ; oboInOwl:creation_date "2011-11-16T04:28:16Z" ; oboInOwl:inSubset cl:general_cell_types_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "bone cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:CL_0001044 obo:IAO_0000115 "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." ; oboInOwl:hasBroadSynonym "effector CD4+ T cell" ; oboInOwl:hasExactSynonym "effector CD4-positive, alpha-beta T lymphocyte", "effector CD4-positive, alpha-beta T-cell", "effector CD4-positive, alpha-beta T-lymphocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." ; rdfs:label "effector CD4-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] ) ] . obo:CL_0001050 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." ; oboInOwl:hasBroadSynonym "effector CD8+ T cell" ; oboInOwl:hasExactSynonym "effector CD8-positive, alpha-beta T lymphocyte", "effector CD8-positive, alpha-beta T-cell", "effector CD8-positive, alpha-beta T-lymphocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." ; rdfs:label "effector CD8-positive, alpha-beta T cell" ; rdfs:subClassOf obo:CL_0000911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0001053 obo:IAO_0000115 "A memory B cell that lacks expression of surface IgD." ; oboInOwl:hasExactSynonym "IgD- memory B cell" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive." ; rdfs:label "IgD-negative memory B cell" ; rdfs:subClassOf obo:CL_0000787 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0001054 obo:IAO_0000115 "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." ; oboInOwl:hasNarrowSynonym "monocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ; rdfs:label "CD14-positive monocyte" ; rdfs:subClassOf obo:CL_0000576 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] ) ] . obo:CL_0001055 obo:IAO_0000115 "An intermediate monocyte that is CD14-positive and with low amounts of CD16." ; oboInOwl:hasExactSynonym "intermediate monocyte, human" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Definition is valid for human intermediate monocytes." ; rdfs:label "CD14-positive, CD16-low monocyte" ; rdfs:subClassOf obo:CL_0002393 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002393 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0001059 obo:IAO_0000115 "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." ; oboInOwl:hasBroadSynonym "CMP" ; oboInOwl:hasExactSynonym "common myeloid precursor, CD34-positive" ; oboInOwl:hasRelatedSynonym "CFU-GEMM", "CFU-S", "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "multipotential myeloid stem cell", "myeloid stem cell", "pluripotent stem cell (bone marrow)" ; a owl:Class ; rdfs:comment "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ; rdfs:label "common myeloid progenitor, CD34-positive" ; rdfs:subClassOf obo:CL_0000049 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001944 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0001060 obo:IAO_0000115 "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:27Z" ; a owl:Class ; rdfs:label "hematopoietic oligopotent progenitor cell, lineage-negative" ; rdfs:subClassOf obo:CL_0002032, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001401 ] ) ] . obo:CL_0001061 obo:IAO_0000115 "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." ; dcterms:contributor ; dcterms:date "2017-01-30T18:53:32Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913" ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "abnormal cell" ; rdfs:subClassOf obo:CL_0000000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . obo:CL_0001062 obo:IAO_0000115 "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; oboInOwl:hasBroadSynonym "TEMRA" ; oboInOwl:hasExactSynonym "CD8+ TEMRA", "CD8-positive TEMRA" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type is seen in human but not found in the mouse." ; rdfs:label "effector memory CD8-positive, alpha-beta T cell, terminally differentiated" ; rdfs:subClassOf obo:CL_0000909, obo:CL_4030002, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000913 ] . obo:CL_0001063 obo:IAO_0000115 "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." ; dcterms:contributor ; dcterms:date "2017-01-30T19:16:26Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922" ; oboInOwl:hasRelatedSynonym "tumor cell", "tumour cell" ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "neoplastic cell" ; rdfs:subClassOf obo:CL_0001061 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001061 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002011 ] ) ] . obo:CL_0001064 obo:IAO_0000115 "A neoplastic cell that is capable of entering a surrounding tissue" ; dcterms:contributor ; dcterms:date "2017-01-30T19:39:12Z"^^xsd:dateTime ; oboInOwl:hasDbXref "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917" ; oboInOwl:hasRelatedSynonym "cancer cell" ; a owl:Class ; rdfs:comment "https://github.com/obophenotype/cell-ontology/issues/448" ; rdfs:label "malignant cell" ; rdfs:subClassOf obo:CL_0001063 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001063 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002097 ] ) ] . obo:CL_0001065 obo:IAO_0000115 "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." ; dcterms:contributor ; dcterms:date "2017-01-30T20:20:48Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "innate lymphoid cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0001066 obo:IAO_0000115 "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." ; oboInOwl:hasDbXref "BTO:0004911" ; oboInOwl:hasRelatedSynonym "BFU-E", "CFU-E", "blast forming unit erythroid", "burst forming unit erythroid", "colony forming unit erythroid", "erythroid stem cell" ; a owl:Class ; rdfs:label "erythroid progenitor cell, mammalian" ; rdfs:subClassOf obo:CL_0000038 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000038 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:CL_0001067 obo:IAO_0000115 "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." ; dcterms:contributor ; dcterms:date "2017-01-30T20:42:44Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "group 1 innate lymphoid cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:CL_0001082 obo:IAO_0000115 "An innate lyphoid cell with an immature phenotype." ; oboInOwl:hasExactSynonym "immature ILC" ; a owl:Class ; rdfs:label "immature innate lymphoid cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001065 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001501 ] ) ] . obo:CL_0001201 obo:IAO_0000115 "A B cell that is CD19-positive." ; dcterms:contributor ; oboInOwl:hasExactSynonym "B lymphocyte, CD19-positive", "B-cell, CD19-positive", "B-lymphocyte, CD19-positive", "CD19+ B cell", "CD19-positive B cell" ; a owl:Class ; rdfs:label "B cell, CD19-positive" ; rdfs:subClassOf obo:CL_0000236 . obo:CL_0001203 obo:IAO_0000115 "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; oboInOwl:hasExactSynonym "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive", "CD8-positive, alpha-beta memory T-cell, CD45RO-positive", "CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8-positive, alpha-beta memory T cell, CD45RO-positive" ; rdfs:subClassOf obo:CL_0000909, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000906 ] . obo:CL_0001204 obo:IAO_0000115 "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; oboInOwl:hasExactSynonym "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive", "CD4-positive, alpha-beta memory T-cell, CD45RO-positive", "CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" ; a owl:Class ; rdfs:label "CD4-positive, alpha-beta memory T cell, CD45RO-positive" ; rdfs:subClassOf obo:CL_0000897, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000896 ] . obo:CL_0002000 obo:IAO_0000115 "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:14:16Z" ; oboInOwl:hasExactSynonym "c- Kit-positive erythroid progenitor cell" ; a owl:Class ; rdfs:comment "Markers found on mouse cells." ; rdfs:label "Kit-positive erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0001066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001066 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000009127 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001345 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002001 obo:IAO_0000115 "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-13T03:19:22Z" ; a owl:Class ; rdfs:comment "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ; rdfs:label "CD34-positive, CD38-positive granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0000557, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001026 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000557 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001865 ] ) ] . obo:CL_0002002 obo:IAO_0000115 "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-13T03:19:28Z" ; a owl:Class ; rdfs:comment "Markers are found on mouse cells." ; rdfs:label "Kit-positive granulocyte monocyte progenitor" ; rdfs:subClassOf obo:CL_0000557, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000557 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0033001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001479 ] ) ] . obo:CL_0002003 obo:IAO_0000115 "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:14:30Z" ; oboInOwl:hasDbXref "FMA:83517" ; a owl:Class ; rdfs:comment "Cell markers associated with human cells." ; rdfs:label "CD34-positive, GlyA-negative erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0001066, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001066 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0002004 obo:IAO_0000115 "A proerythoblast that is CD34-negative and GlyA-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:31:50Z" ; a owl:Class ; rdfs:comment "Cell surface markers are associated with human cells." ; rdfs:label "CD34-negative, GlyA-negative proerythroblast" ; rdfs:subClassOf obo:CL_0000547, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000547 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002005 obo:IAO_0000115 "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-13T03:43:10Z" ; a owl:Class ; rdfs:comment "Markers are associated with human cell type." ; rdfs:label "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000050 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002006 obo:IAO_0000115 "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-13T03:43:12Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell" ; rdfs:subClassOf obo:CL_0000050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000050 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0033001 ] ) ] . obo:CL_0002009 obo:IAO_0000115 "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-19T02:51:58Z" ; oboInOwl:hasExactSynonym "MDP" ; a owl:Class ; rdfs:label "macrophage dendritic cell progenitor" ; rdfs:subClassOf obo:CL_0002032, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043011 ] ) ] . obo:CL_0002010 obo:IAO_0000115 "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." ; oboInOwl:creation_date "2010-01-19T03:39:30Z" ; a owl:Class ; rdfs:label "pre-conventional dendritic cell" ; rdfs:subClassOf obo:CL_0002031, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002031 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001024 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001839 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001889 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002978 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] ) ] . obo:CL_0002011 obo:IAO_0000115 "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-26T02:43:40Z" ; oboInOwl:hasExactSynonym "murine MDP" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive macrophage dendritic cell progenitor" ; rdfs:subClassOf obo:CL_0002009, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002009 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002012 obo:IAO_0000115 "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:31:56Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-low proerythroblast" ; rdfs:subClassOf obo:CL_0000547, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002000 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000547 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002013 obo:IAO_0000115 "A basophilic erythroblast that is GlyA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:41:15Z" ; a owl:Class ; rdfs:comment "Markers are associated with human cells." ; rdfs:label "GlyA-positive basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000549, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000549 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002014 obo:IAO_0000115 "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:41:22Z" ; a owl:Class ; rdfs:comment "Cell surface markers are associated with mouse cells." ; rdfs:label "Kit-negative, Ly-76 high basophilic erythroblast" ; rdfs:subClassOf obo:CL_0000549, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000549 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002015 obo:IAO_0000115 "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:53:11Z" ; oboInOwl:hasBroadSynonym "late basophilic and polychromatophilic erythroblast" ; a owl:Class ; rdfs:label "Kit-negative, Ly-76 high polychromatophilic erythroblast" ; rdfs:subClassOf obo:CL_0000550, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000550 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002016 obo:IAO_0000115 "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T10:53:16Z" ; a owl:Class ; rdfs:comment "Cell surface markers are associated with human cells." ; rdfs:label "CD71-low, GlyA-positive polychromatic erythroblast" ; rdfs:subClassOf obo:CL_0000550, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000550 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0002017 obo:IAO_0000115 "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:04:15Z" ; a owl:Class ; rdfs:comment "Cell surface markers associated with mouse cells." ; rdfs:label "Kit-negative, Ly-76 high orthochromatophilic erythroblasts" ; rdfs:subClassOf obo:CL_0000552, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000552 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001945 ] ) ] . obo:CL_0002018 obo:IAO_0000115 "An erythroblast that is GlyA-positive and CD71-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:04:21Z" ; a owl:Class ; rdfs:comment "Markers associated with human cells." ; rdfs:label "CD71-negative, GlyA-positive orthochromatic erythroblast" ; rdfs:subClassOf obo:CL_0000552, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000552 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002019 obo:IAO_0000115 "A reticulocyte that is Ly76-high and is Kit-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:37:00Z" ; a owl:Class ; rdfs:comment "Marker associated with mouse cells." ; rdfs:label "Ly-76 high reticulocyte" ; rdfs:subClassOf obo:CL_0002422, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002422 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002020 obo:IAO_0000115 "A reticulocyte that is GlyA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:48:25Z" ; a owl:Class ; rdfs:comment "Markers is associated with human cells." ; rdfs:label "GlyA-positive reticulocytes" ; rdfs:subClassOf obo:CL_0002422, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002422 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002021 obo:IAO_0000115 "An enucleate erythrocyte that is GlyA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:51:22Z" ; a owl:Class ; rdfs:comment "Marker is associated with human cell types." ; rdfs:label "GlyA-positive erythrocyte" ; rdfs:subClassOf obo:CL_0000595, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001460 ] ) ] . obo:CL_0002022 obo:IAO_0000115 "An enucleate erythrocyte that is Lyg-76-high." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T11:51:27Z" ; a owl:Class ; rdfs:comment "Marker is associated with mouse cell types." ; rdfs:label "Ly-76 high positive erythrocyte" ; rdfs:subClassOf obo:CL_0000595, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002019 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002981 ] ) ] . obo:CL_0002024 obo:IAO_0000115 "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-26T02:39:15Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive megakaryocyte progenitor cell" ; rdfs:subClassOf obo:CL_0000553, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000553 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0002027 obo:IAO_0000115 "A megakaryocyte cell with is CD9-positive and CD41-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-27T10:39:07Z" ; a owl:Class ; rdfs:comment "Markers are commonly associated with mouse cells." ; rdfs:label "CD9-positive, CD41-positive megakaryocyte cell" ; rdfs:subClassOf obo:CL_0000556, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000005178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009127 ] ) ] . obo:CL_0002028 obo:IAO_0000115 "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" ; dcterms:contributor ; oboInOwl:creation_date "2010-04-27T12:46:33Z" ; oboInOwl:hasExactSynonym "BMCP" ; a owl:Class ; rdfs:comment "There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low." ; rdfs:label "basophil mast progenitor cell" ; rdfs:subClassOf obo:CL_0000839, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000557 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000005307 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007857 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007858 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000007431 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000016401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060374 ] ) ] . obo:CL_0002029 obo:IAO_0000115 "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:19Z" ; a owl:Class ; rdfs:label "Fc-epsilon RIalpha-low mast cell progenitor" ; rdfs:subClassOf obo:CL_0000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000831 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000009143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0002030 obo:IAO_0000115 "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:32Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Fc-epsilon RIalpha-high basophil progenitor cell" ; rdfs:subClassOf obo:CL_0000613, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002044 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000613 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000007431 ] ) ] . obo:CL_0002031 obo:IAO_0000115 "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:20Z" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "hematopoietic lineage restricted progenitor cell" ; rdfs:subClassOf obo:CL_0000988, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002032 ] ; owl:disjointWith obo:CL_0002032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001400 ] ) ] . obo:CL_0002032 obo:IAO_0000115 "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-06T03:43:27Z" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:comment "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ; rdfs:label "hematopoietic oligopotent progenitor cell" ; rdfs:subClassOf obo:CL_0000988, obo:CL_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001401 ] ) ] . obo:CL_0002033 obo:IAO_0000115 "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-08T09:19:25Z" ; oboInOwl:hasExactSynonym "ST stem cell", "ST-HSC" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ; rdfs:label "short term hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0001008, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002034 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001008 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] ) ] . obo:CL_0002034 obo:IAO_0000115 "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-08T09:19:28Z" ; oboInOwl:hasExactSynonym "LT stem cell", "LT-HSC" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "long term hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0001008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001008 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001003 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001843 ] ) ] . obo:CL_0002035 obo:IAO_0000115 "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-08T11:16:33Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Slamf1-negative multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002036 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002036 obo:IAO_0000115 "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-08T11:16:35Z" ; oboInOwl:hasExactSynonym "KSL cell" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Slamf1-positive multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002033 ] ; owl:disjointWith obo:CL_0002043 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002043 obo:IAO_0000115 "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-01-12T11:14:15Z" ; a owl:Class ; rdfs:comment "Cell markers are associated with human hematopoietic multipotent progenitor cells." ; rdfs:label "CD34-positive, CD38-negative multipotent progenitor cell" ; rdfs:subClassOf obo:CL_0000837, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0001024 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000837 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001843 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001003 ] ) ] . obo:CL_0002044 obo:IAO_0000115 "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-27T01:22:38Z" ; a owl:Class ; rdfs:comment "Markers are associated with mouse cells." ; rdfs:label "Kit-positive, integrin beta7-high basophil mast progenitor cell" ; rdfs:subClassOf obo:CL_0002028 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002028 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000009143 ] ) ] . obo:CL_0002045 obo:IAO_0000115 "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T10:50:07Z" ; oboInOwl:hasBroadSynonym "fraction A" ; oboInOwl:hasRelatedSynonym "pre pro B cell" ; a owl:Class ; rdfs:comment "Markers associated with mouse cells." ; rdfs:label "fraction A pre-pro B cell" ; rdfs:subClassOf obo:CL_0000826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000826 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002047 obo:IAO_0000115 "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T11:56:21Z" ; oboInOwl:hasBroadSynonym "Fr. B", "Fraction B" ; a owl:Class ; rdfs:comment "Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive." ; rdfs:label "fraction B precursor B cell" ; rdfs:subClassOf obo:CL_0002400, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002045 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002400 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002049 obo:IAO_0000115 "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T02:04:01Z" ; oboInOwl:hasRelatedSynonym "Fraction C" ; a owl:Class ; rdfs:label "fraction C precursor B cell" ; rdfs:subClassOf obo:CL_0002400, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002400 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001858 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000001859 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003457 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000003460 ] ) ] . obo:CL_0002050 obo:IAO_0000115 "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T02:13:46Z" ; oboInOwl:hasBroadSynonym "Fr. C'", "Fraction C-prime" ; a owl:Class ; rdfs:label "fraction C' precursor B cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002052 obo:IAO_0000115 "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T02:55:16Z" ; oboInOwl:hasBroadSynonym "Fr. D" ; oboInOwl:hasExactSynonym "fraction D pre-B cell" ; a owl:Class ; rdfs:comment "Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative." ; rdfs:label "fraction D precursor B cell" ; rdfs:subClassOf obo:CL_0000817, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0071708 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0035369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0002054 obo:IAO_0000115 "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-28T03:13:47Z" ; a owl:Class ; rdfs:comment "Markers associated with mouse cells. These cells are also reportedly sIgD-negative." ; rdfs:label "fraction E immature B cell" ; rdfs:subClassOf obo:CL_0000816, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001879 ] ) ] . obo:CL_0002056 obo:IAO_0000115 "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-04-30T03:01:48Z" ; a owl:Class ; rdfs:label "fraction F mature B cell" ; rdfs:subClassOf obo:CL_0000785, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002054 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000785 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001880 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001338 ] ) ] . obo:CL_0002059 obo:IAO_0000115 "A conventional thymic dendritic cell that is CD8alpha-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-07T02:48:36Z" ; oboInOwl:hasExactSynonym "CD8alpha-alpha-positive thymic conventional dendritic cell", "DC.8+.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8alpha-positive thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000941 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000941 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002062 obo:IAO_0000115 "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-23T04:37:54Z" ; oboInOwl:hasDbXref "BTO:0000780", "FMA:62500" ; oboInOwl:hasExactSynonym "AT1", "ATI", "lung type 1 cells", "membranous pneumocytes", "pulmonary alveolar type I cell", "small alveolar cells", "squamous alveolar cell", "squamous alveolar lining cell", "type 1 alveolar epithelial cells", "type 1 pneumocyte", "type I alveolar cells", "type I alveolar epithelial cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "type I pneumocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:CL_0002063 obo:IAO_0000115 "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-24T12:04:13Z" ; oboInOwl:hasDbXref "BTO:0000538", "FMA:62501" ; oboInOwl:hasExactSynonym "AT2", "ATII", "TII", "cuboidal type II cell", "granular pneumocyte", "great alveolar cell", "lung type 2 cell", "type 2 alveolar epithelial cell", "type 2 alveolocyte", "type 2 pneumocyte", "type II alveolar cell", "type II alveolar epithelial cell", "type II alveolocyte" ; oboInOwl:hasRelatedSynonym "lung type II cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "type II pneumocyte" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_4040003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032940 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043129 ] ) ] . obo:CL_0002064 obo:IAO_0000115 "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-24T03:16:29Z" ; oboInOwl:hasDbXref "BTO:0000028", "CALOHA:TS-0737", "FMA:63032" ; oboInOwl:hasExactSynonym "acinar cell of pancreas" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic acinar cell" ; rdfs:subClassOf obo:CL_0000083, obo:CL_0000622, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ] ) ] . obo:CL_0002067 obo:IAO_0000115 "An enteroendocrine cell that produces glucagon." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T10:48:54Z" ; oboInOwl:hasDbXref "FMA:62939" ; a owl:Class ; rdfs:label "type A enteroendocrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:CL_0002068 obo:IAO_0000115 "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-28T08:36:15Z" ; oboInOwl:hasDbXref "BTO:0001032", "FMA:14146" ; oboInOwl:hasExactSynonym "Purkinje cell fiber", "Purkinje muscle cell", "myocytus conducens cardiacus" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "Purkinje myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002072 obo:IAO_0000115 "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T11:41:37Z" ; oboInOwl:hasBroadSynonym "pacemaker cell" ; oboInOwl:hasDbXref "BTO:0004190", "FMA:67101" ; oboInOwl:hasExactSynonym "P cell", "cardiac pacemaker cell", "myocytus nodalis" ; a owl:Class ; rdfs:label "nodal myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002073 obo:IAO_0000115 "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T02:39:32Z" ; oboInOwl:hasDbXref "FMA:67142" ; a owl:Class ; rdfs:label "transitional myocyte" ; rdfs:subClassOf obo:CL_0002086 . obo:CL_0002074 obo:IAO_0000115 "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T11:50:47Z" ; oboInOwl:hasDbXref "FMA:67111" ; a owl:Class ; rdfs:label "myocardial endocrine cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0002086 . obo:CL_0002076 obo:IAO_0000115 "An epithelial cell derived from endoderm." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T03:38:14Z" ; oboInOwl:hasDbXref "FMA:69075" ; a owl:Class ; rdfs:label "endo-epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000223 ] . obo:CL_0002077 obo:IAO_0000115 "An epithelial cell derived from ectoderm." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T03:38:22Z" ; oboInOwl:hasDbXref "FMA:69074" ; a owl:Class ; rdfs:label "ecto-epithelial cell" ; rdfs:subClassOf obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000221 ] ) ] . obo:CL_0002078 obo:IAO_0000115 "Epithelial cell derived from mesoderm or mesenchyme." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-29T03:49:14Z" ; oboInOwl:hasDbXref "FMA:69076" ; oboInOwl:hasExactSynonym "epithelial mesenchymal cell" ; a owl:Class ; rdfs:label "meso-epithelial cell" ; rdfs:subClassOf obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000222 ] ) ] . obo:CL_0002079 obo:IAO_0000115 "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-30T08:49:43Z" ; oboInOwl:hasDbXref "FMA:63099" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic ductal cell" ; rdfs:subClassOf obo:CL_0000069, obo:CL_0000083 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] . obo:CL_0002080 obo:IAO_0000115 "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." ; dcterms:contributor ; oboInOwl:creation_date "2010-06-30T08:49:52Z" ; oboInOwl:hasDbXref "FMA:62455" ; oboInOwl:hasExactSynonym "centroacinar cell of Langerhans", "pancreatic centroacinar cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic centro-acinar cell" ; rdfs:subClassOf obo:CL_0000083 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001263 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] . obo:CL_0002082 obo:IAO_0000115 "A chromaffin cell of the adrenal medulla that produces epinephrine." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-14T09:41:42Z" ; oboInOwl:hasDbXref "FMA:69322" ; oboInOwl:hasExactSynonym "adremergic chromaffin cell", "adrenal secreting cell of the adrenal medulla", "epiniphrine secreting cell of the adrenal medulla" ; a owl:Class ; rdfs:label "type II cell of adrenal medulla" ; rdfs:subClassOf obo:CL_0000336 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000336 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:CL_0002083 obo:IAO_0000115 "A chromaffin cell of the adrenal medulla that produces norepinephrine." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-14T10:12:24Z" ; oboInOwl:hasDbXref "FMA:69321" ; oboInOwl:hasExactSynonym "noradrenergic chromaffin cell" ; a owl:Class ; rdfs:label "type I cell of adrenal medulla" ; rdfs:subClassOf obo:CL_0000336 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000336 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:CL_0002086 obo:IAO_0000115 "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-21T01:33:38Z" ; oboInOwl:hasDbXref "FMA:67968" ; a owl:Class ; rdfs:label "specialized cardiac myocyte" ; rdfs:subClassOf obo:CL_0000746 . obo:CL_0002087 obo:IAO_0000115 "A leukocyte that lacks granules." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-22T11:30:33Z" ; oboInOwl:hasDbXref "FMA:62855" ; oboInOwl:hasExactSynonym "agranular leukocyte" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "nongranular leukocyte" ; rdfs:subClassOf obo:CL_0000738 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:CL_4030045 ; owl:someValuesFrom obo:GO_0030141 ] ) ] . obo:CL_0002092 obo:IAO_0000115 "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-22T04:48:15Z" ; oboInOwl:hasDbXref "BTO:0004850", "FMA:83621", "MESH:D001854" ; a owl:Class ; rdfs:comment "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense." ; rdfs:label "bone marrow cell" ; rdfs:subClassOf obo:CL_0001035 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001035 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002095 obo:IAO_0000115 "A cell in the hilum of the ovary that produces androgens." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-23T11:18:18Z" ; oboInOwl:hasDbXref "FMA:18710" ; oboInOwl:hasExactSynonym "hilar cell of ovary" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hilus cell of ovary" ; rdfs:subClassOf obo:CL_0000593, obo:CL_0002132 . obo:CL_0002097 obo:IAO_0000115 "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T01:37:44Z" ; oboInOwl:hasDbXref "FMA:69545" ; oboInOwl:hasExactSynonym "adrenal cortex cell", "adrenocortical cell" ; a owl:Class ; rdfs:label "cortical cell of adrenal gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000174, obo:CL_0002078 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002078 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_0002101 obo:IAO_0000115 "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "CD38+ naive B cell", "CD38+ naive B lymphocyte", "CD38+ naive B-cell", "CD38+ naive B-lymphocyte", "CD38-positive naive B lymphocyte", "CD38-positive naive B-cell", "CD38-positive naive B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0000788 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002102 obo:IAO_0000115 "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "CD38- naive B cell", "CD38- naive B lymphocyte", "CD38- naive B-cell", "CD38- naive B-lymphocyte", "CD38-negative naive B lymphocyte", "CD38-negative naive B-cell", "CD38-negative naive B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-negative naive B cell" ; rdfs:subClassOf obo:CL_0000788 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002103 obo:IAO_0000115 "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." ; oboInOwl:hasExactSynonym "IgG+ dn memory B cell", "IgG+ dn memory B lymphocyte", "IgG+ dn memory B-cell", "IgG+ dn memory B-lymphocyte", "IgG+ double negative memory B cell", "IgG+ double negative memory B lymphocyte", "IgG+ double negative memory B-cell", "IgG+ double negative memory B-lymphocyte", "IgG-positive dn memory B cell", "IgG-positive dn memory B lymphocyte", "IgG-positive dn memory B-cell", "IgG-positive dn memory B-lymphocyte", "IgG-positive double negative memory B lymphocyte", "IgG-positive double negative memory B-cell", "IgG-positive double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "IgG-positive double negative memory B cell" ; rdfs:subClassOf obo:CL_0000981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000981 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002104 obo:IAO_0000115 "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." ; oboInOwl:hasExactSynonym "IgG- dn memory B cell", "IgG- dn memory B lymphocyte", "IgG- dn memory B-cell", "IgG- dn memory B-lymphocyte", "IgG- double negative memory B cell", "IgG- double negative memory B lymphocyte", "IgG- double negative memory B-cell", "IgG- double negative memory B-lymphocyte", "IgG-negative dn memory B cell", "IgG-negative dn memory B lymphocyte", "IgG-negative dn memory B-cell", "IgG-negative dn memory B-lymphocyte", "IgG-negative double negative memory B lymphocyte", "IgG-negative double negative memory B-cell", "IgG-negative double negative memory B-lymphocyte" ; a owl:Class ; rdfs:label "IgG-negative double negative memory B cell" ; rdfs:subClassOf obo:CL_0000981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000981 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002105 obo:IAO_0000115 "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." ; oboInOwl:hasExactSynonym "CD38+ IgG memory B cell", "CD38+ IgG memory B lymphocyte", "CD38+ IgG memory B-cell", "CD38+ IgG memory B-lymphocyte", "CD38-positive IgG memory B lymphocyte", "CD38-positive IgG memory B-cell", "CD38-positive IgG memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0000979 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000979 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002106 obo:IAO_0000115 "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "IgD-positive CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0002105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002105 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0002107 obo:IAO_0000115 "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "IgD-negative CD38-positive IgG memory B cell" ; rdfs:subClassOf obo:CL_0002105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002105 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] ) ] . obo:CL_0002108 obo:IAO_0000115 "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." ; a owl:Class ; rdfs:label "CD38-negative IgG memory B cell" ; rdfs:subClassOf obo:CL_0000979 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000979 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071738 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002109 obo:IAO_0000115 "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." ; oboInOwl:hasExactSynonym "B220+CD38+ naive B cell", "B220+CD38+ naive B lymphocyte", "B220+CD38+ naive B-cell", "B220+CD38+ naive B-lymphocyte", "B220-positive CD38-positive naive B lymphocyte", "B220-positive CD38-positive naive B-cell", "B220-positive CD38-positive naive B-lymphocyte", "CD38+B220+ naive B cell", "CD38+B220+ naive B lymphocyte", "CD38+B220+ naive B-cell", "CD38+B220+ naive B-lymphocyte" ; a owl:Class ; rdfs:label "B220-positive CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0002101 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002101 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002110 obo:IAO_0000115 "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." ; a owl:Class ; rdfs:label "B220-low CD38-positive naive B cell" ; rdfs:subClassOf obo:CL_0002101 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002101 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002111 obo:IAO_0000115 "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; oboInOwl:hasExactSynonym "CD38- unswitched memory B cell", "CD38- unswitched memory B lymphocyte", "CD38- unswitched memory B-cell", "CD38- unswitched memory B-lymphocyte", "CD38-negative unswitched memory B lymphocyte", "CD38-negative unswitched memory B-cell", "CD38-negative unswitched memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000970 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002112 obo:IAO_0000115 "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002111 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002111 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002113 obo:IAO_0000115 "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-low CD38-negative unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002111 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002111 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002114 obo:IAO_0000115 "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; oboInOwl:hasExactSynonym "CD38+ unswitched memory B cell", "CD38+ unswitched memory B lymphocyte", "CD38+ unswitched memory B-cell", "CD38+ unswitched memory B-lymphocyte", "CD38-positive unswitched memory B lymphocyte", "CD38-positive unswitched memory B-cell", "CD38-positive unswitched memory B-lymphocyte" ; a owl:Class ; rdfs:label "CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0000970 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002115 obo:IAO_0000115 "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002114 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002114 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002116 obo:IAO_0000115 "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." ; a owl:Class ; rdfs:label "B220-low CD38-positive unswitched memory B cell" ; rdfs:subClassOf obo:CL_0002114 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002114 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002117 obo:IAO_0000115 "A class switched memory B cell that lacks IgG on the cell surface." ; oboInOwl:hasExactSynonym "IgG- class switched memory B cell", "IgG- class switched memory B lymphocyte", "IgG- class switched memory B-cell", "IgG- class switched memory B-lymphocyte", "IgG-negative class switched memory B lymphocyte", "IgG-negative class switched memory B-cell", "IgG-negative class switched memory B-lymphocyte" ; a owl:Class ; rdfs:label "IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0000972 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071735 ] ) ] . obo:CL_0002118 obo:IAO_0000115 "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." ; a owl:Class ; rdfs:label "CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002117 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002119 obo:IAO_0000115 "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." ; a owl:Class ; rdfs:label "CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002117 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001408 ] ) ] . obo:CL_0002120 obo:IAO_0000115 "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." ; a owl:Class ; rdfs:label "CD24-positive CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002118 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002118 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002121 obo:IAO_0000115 "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." ; a owl:Class ; rdfs:label "CD24-negative CD38-negative IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002118 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002118 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002122 obo:IAO_0000115 "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." ; a owl:Class ; rdfs:label "B220-positive CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002119 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002119 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002123 obo:IAO_0000115 "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." ; a owl:Class ; rdfs:label "B220-low CD38-positive IgG-negative class switched memory B cell" ; rdfs:subClassOf obo:CL_0002119 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002119 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002124 obo:IAO_0000115 "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-18T09:57:19Z" ; oboInOwl:hasExactSynonym "gammadelta27-positive", "gd27-positive" ; a owl:Class ; rdfs:label "CD27-positive gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000800, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002126 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000800 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001963 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:CL_0002126 obo:IAO_0000115 "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-18T10:35:37Z" ; a owl:Class ; rdfs:label "CD25-positive, CD27-positive immature gamma-delta T cell" ; rdfs:subClassOf obo:CL_0000799 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001919 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001083 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001839 ] ) ] . obo:CL_0002127 obo:IAO_0000115 "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-20T02:14:25Z" ; a owl:Class ; rdfs:label "innate effector T cell" ; rdfs:subClassOf obo:CL_0000911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:CL_0002132 obo:IAO_0000115 "A stomal cell of the ovary" ; dcterms:contributor ; oboInOwl:creation_date "2010-08-23T12:10:31Z" ; oboInOwl:hasDbXref "FMA:72299" ; oboInOwl:hasExactSynonym "ovarian stromal cell" ; a owl:Class ; rdfs:label "stromal cell of ovary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_0002134 obo:IAO_0000115 "A stromal cell of the ovarian medulla." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-23T12:12:17Z" ; oboInOwl:hasDbXref "FMA:256171" ; a owl:Class ; rdfs:label "stromal cell of ovarian medulla" ; rdfs:subClassOf obo:CL_0002132 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013192 ] ) ] . obo:CL_0002138 obo:IAO_0000115 "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T02:05:28Z" ; oboInOwl:hasDbXref "BTO:0004167", "FMA:68458" ; oboInOwl:hasExactSynonym "LEC", "lymphatic endothelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of lymphatic vessel" ; rdfs:subClassOf obo:CL_0002139 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005022 ] ) ] . obo:CL_0002139 obo:IAO_0000115 "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T02:06:40Z" ; oboInOwl:hasDbXref "BTO:0001854", "CALOHA:TS-1106", "FMA:67755" ; oboInOwl:hasExactSynonym "vascular endothelial cell" ; oboInOwl:hasNarrowSynonym "cubodial endothelial cell of vascular tree" ; a owl:Class ; rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive." ; rdfs:label "endothelial cell of vascular tree" ; rdfs:subClassOf obo:CL_0000115 . obo:CL_0002140 obo:IAO_0000115 "A sebum secreting cell of the skin that secretes sebum into the hair follicles." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T09:27:52Z" ; oboInOwl:hasBroadSynonym "sebocyte" ; oboInOwl:hasDbXref "BTO:0004613", "FMA:70953" ; a owl:Class ; rdfs:label "acinar cell of sebaceous gland" ; rdfs:subClassOf obo:CL_0000317, obo:CL_0000622, obo:CL_1000448 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000317 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003487 ] ) ] . obo:CL_0002144 obo:IAO_0000115 "An endothelial cell found in capillaries." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T10:15:00Z" ; oboInOwl:hasDbXref "BTO:0004956", "CALOHA:TS-0112", "FMA:67756" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001915 ] ) ] . obo:CL_0002145 obo:IAO_0000115 "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T03:38:29Z" ; oboInOwl:hasDbXref "FMA:70542" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ciliated columnar cell of tracheobronchial tree" ; rdfs:subClassOf obo:CL_0002202, obo:CL_0005012, obo:CL_4030034, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002209 ] . obo:CL_0002148 obo:IAO_0000115 "A cell found within the dental pulp." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T02:52:09Z" ; oboInOwl:hasDbXref "CALOHA:TS-0195", "FMA:87170" ; a owl:Class ; rdfs:label "dental pulp cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002159 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001754 ] ) ] . obo:CL_0002149 obo:IAO_0000115 "An epithelial cell of the uterus." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T10:45:54Z" ; oboInOwl:hasDbXref "FMA:256161" ; a owl:Class ; rdfs:label "epithelial cell of uterus" ; rdfs:subClassOf obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_0002153 obo:IAO_0000115 "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-24T10:53:03Z" ; oboInOwl:hasDbXref "BTO:0001943", "FMA:68650" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "corneocyte" ; rdfs:subClassOf obo:CL_0000225, obo:CL_0000311, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000312 ] . obo:CL_0002159 obo:IAO_0000115 "Epithelial cells derived from general body ectoderm and ectoderm placodes." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T08:31:08Z" ; oboInOwl:hasDbXref "FMA:70556" ; a owl:Class ; rdfs:label "general ecto-epithelial cell" ; rdfs:subClassOf obo:CL_0002077 . obo:CL_0002166 obo:IAO_0000115 "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T08:51:27Z" ; oboInOwl:hasDbXref "FMA:62987" ; oboInOwl:hasExactSynonym "epithelial cell rests of Malassez", "epithelial debris of Malassez" ; a owl:Class ; rdfs:label "epithelial cell of Malassez" ; rdfs:subClassOf obo:CL_0002159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ] . obo:CL_0002167 obo:IAO_0000115 "A specialized cell involved in sensory perception of smell." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T01:47:13Z" ; oboInOwl:hasDbXref "FMA:67870" ; a owl:Class ; rdfs:label "olfactory epithelial cell" ; rdfs:subClassOf obo:CL_0000098, obo:CL_0000710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ) ] . obo:CL_0002170 obo:IAO_0000115 "A keratinized cell located in the hard palate or gingiva." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T02:51:30Z" ; a owl:Class ; rdfs:label "keratinized cell of the oral mucosa" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0002336, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] ) ] . obo:CL_0002177 obo:IAO_0000115 "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-25T03:10:10Z" ; oboInOwl:hasDbXref "FMA:83102" ; oboInOwl:hasExactSynonym "folliculostellate cell of pars anterior of adenohypophysis" ; a owl:Class ; rdfs:label "folliculostellate cell of pars distalis of adenohypophysis" ; rdfs:subClassOf obo:CL_0000642, obo:CL_0000710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000642 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006964 ] ) ] . obo:CL_0002178 obo:IAO_0000115 "An epithelial cell found in the lining of the stomach." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-25T03:22:08Z" ; oboInOwl:hasDbXref "FMA:62948" ; a owl:Class ; rdfs:label "epithelial cell of stomach" ; rdfs:subClassOf obo:CL_0002251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_0002180 obo:IAO_0000115 "A mucous cell in the epithelium of the stomach." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-25T03:38:51Z" ; oboInOwl:hasDbXref "FMA:63464" ; a owl:Class ; rdfs:label "mucous cell of stomach" ; rdfs:subClassOf obo:CL_0002178, obo:CL_0002659 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001199 ] ) ] . obo:CL_0002183 obo:IAO_0000115 "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-25T03:57:08Z" ; oboInOwl:hasDbXref "FMA:62953" ; a owl:Class ; rdfs:label "stem cell of gastric gland" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002178 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000325 ] ) ] . obo:CL_0002187 obo:IAO_0000115 "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T03:12:49Z" ; oboInOwl:hasDbXref "FMA:70571" ; a owl:Class ; rdfs:label "basal cell of epidermis" ; rdfs:subClassOf obo:CL_0000312, obo:CL_0000646 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_0002188 obo:IAO_0000115 "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-26T10:59:44Z" ; oboInOwl:hasDbXref "BTO:0004632", "FMA:70970" ; a owl:Class ; rdfs:label "glomerular endothelial cell" ; rdfs:subClassOf obo:CL_0000115, obo:CL_0000666 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:CL_0002191 obo:IAO_0000115 "A cell involved in the formation of a granulocyte." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-30T12:54:27Z" ; oboInOwl:hasDbXref "FMA:83519" ; a owl:Class ; rdfs:label "granulocytopoietic cell" ; rdfs:subClassOf obo:CL_0000839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:CL_0002194 obo:IAO_0000115 "A cell involved in the formation of a monocyte (monopoiesis)." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-30T01:27:48Z" ; oboInOwl:hasDbXref "FMA:83552" ; a owl:Class ; rdfs:label "monopoietic cell" ; rdfs:subClassOf obo:CL_0000839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000839 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:CL_0002195 obo:IAO_0000115 "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-30T02:00:42Z" ; oboInOwl:hasDbXref "FMA:86577" ; oboInOwl:hasExactSynonym "HpSC" ; a owl:Class ; rdfs:label "hepatic stem cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" ; rdfs:subClassOf obo:CL_0000048 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_0002198 obo:IAO_0000115 "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T11:26:49Z" ; oboInOwl:hasDbXref "FMA:67606", "MESH:D024862" ; oboInOwl:hasExactSynonym "oxyphil" ; a owl:Class ; rdfs:label "oncocyte" ; rdfs:subClassOf obo:CL_0002076 . obo:CL_0002199 obo:IAO_0000115 "An oncocyte located in the parathyroid gland." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T11:33:23Z" ; oboInOwl:hasDbXref "FMA:69084" ; a owl:Class ; rdfs:label "oxyphil cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0002198, obo:CL_0002260 . obo:CL_0002200 obo:IAO_0000115 "An oncocyte located in the thyroid." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T11:33:26Z" ; oboInOwl:hasDbXref "FMA:87169" ; oboInOwl:hasExactSynonym "Askanazy cells", "Hurthle cells" ; a owl:Class ; rdfs:label "oxyphil cell of thyroid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002198 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:CL_0002202 obo:IAO_0000115 "An epithelial cell of the tracheobronchial tree." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T02:09:14Z" ; oboInOwl:hasDbXref "FMA:66816" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of tracheobronchial tree" ; rdfs:subClassOf obo:CL_0002632 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0002209 obo:IAO_0000115 "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T02:53:59Z" ; oboInOwl:hasDbXref "FMA:69060" ; oboInOwl:hasExactSynonym "undifferentiated columnar cell of tracheobronchial tree" ; a owl:Class ; rdfs:label "intermediate epitheliocyte" ; rdfs:subClassOf obo:CL_0002202 . obo:CL_0002220 obo:IAO_0000115 "A cell located between the pinealocytes." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-02T04:28:41Z" ; oboInOwl:hasDbXref "FMA:86575" ; a owl:Class ; rdfs:label "interstitial cell of pineal gland" ; rdfs:subClassOf obo:CL_0000710 . obo:CL_0002222 obo:IAO_0000115 "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T10:38:03Z" ; oboInOwl:hasDbXref "FMA:70950" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "vertebrate lens cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000306, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ] . obo:CL_0002224 obo:IAO_0000115 "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T10:45:47Z" ; oboInOwl:hasDbXref "FMA:67559" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lens epithelial cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001803 ] ) ] . obo:CL_0002231 obo:IAO_0000115 "An epithelial cell of the prostate." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T01:49:29Z" ; oboInOwl:hasDbXref "FMA:256163", "FMA:66817" ; oboInOwl:hasExactSynonym "prostate epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of prostate" ; rdfs:subClassOf obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002232 obo:IAO_0000115 "An epithelial cell of prostatic duct." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T01:55:51Z" ; oboInOwl:hasDbXref "FMA:74224" ; oboInOwl:hasExactSynonym "ductal epithelial cell of prostate" ; a owl:Class ; rdfs:label "epithelial cell of prostatic duct" ; rdfs:subClassOf obo:CL_0000072, obo:CL_0002231 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ) ] . obo:CL_0002236 obo:IAO_0000115 "A cell that constitutes the basal layer of epithelium in the prostatic duct." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T01:59:12Z" ; oboInOwl:hasDbXref "FMA:74226" ; a owl:Class ; rdfs:label "basal epithelial cell of prostatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002341 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002485 ] ) ] . obo:CL_0002240 obo:IAO_0000115 "A fibroblast in the bone marrow." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T02:25:18Z" ; oboInOwl:hasDbXref "FMA:84377" ; a owl:Class ; rdfs:label "marrow fibroblast" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002241 obo:IAO_0000115 "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T02:29:38Z" ; oboInOwl:hasDbXref "FMA:84467" ; oboInOwl:hasExactSynonym "pulmonary myofibroblast", "pulmonary septal cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pulmonary interstitial fibroblast" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005169 ] ) ] . obo:CL_0002242 obo:IAO_0000115 "A cell containing at least one nucleus." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T03:32:33Z" ; oboInOwl:hasDbXref "FMA:67513" ; a owl:Class ; rdfs:label "nucleate cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] . obo:CL_0002243 obo:IAO_0000115 "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T08:53:42Z" ; oboInOwl:hasDbXref "FMA:70611" ; oboInOwl:hasExactSynonym "smooth muscle fiber of sphincter of pupil" ; oboInOwl:hasRelatedSynonym "smooth muscle fibre of sphincter of pupil" ; a owl:Class ; rdfs:label "smooth muscle cell of sphincter of pupil" ; rdfs:subClassOf obo:CL_0000358, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001607 ] ) ] . obo:CL_0002246 obo:IAO_0000115 "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-07T03:57:09Z" ; oboInOwl:hasDbXref "BTO:0002669", "FMA:86711", "MESH:D000072916" ; oboInOwl:hasExactSynonym "PBSC" ; a owl:Class ; rdfs:label "peripheral blood stem cell" ; rdfs:subClassOf obo:CL_0000037 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_0002251 obo:IAO_0000115 "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T09:26:53Z" ; a owl:Class ; rdfs:label "epithelial cell of alimentary canal" ; rdfs:subClassOf obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:CL_0002252 obo:IAO_0000115 "An epithelial cell of the esophagus." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T09:28:20Z" ; oboInOwl:hasDbXref "FMA:63071" ; a owl:Class ; rdfs:label "epithelial cell of esophagus" ; rdfs:subClassOf obo:CL_0002251 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:CL_0002253 obo:IAO_0000115 "An epithelial cell of the large intestine." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T09:28:22Z" ; oboInOwl:hasDbXref "BTO:0004297", "FMA:256157" ; oboInOwl:hasRelatedSynonym "epithelial cell of colon" ; a owl:Class ; rdfs:label "epithelial cell of large intestine" ; rdfs:subClassOf obo:CL_0002563 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002563 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_0002254 obo:IAO_0000115 "An epithelial cell of the small intestine." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T09:41:46Z" ; oboInOwl:hasDbXref "FMA:256159" ; a owl:Class ; rdfs:label "epithelial cell of small intestine" ; rdfs:subClassOf obo:CL_0002563 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002563 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0002255 obo:IAO_0000115 "A stromal cell of the endometrium that is fibroblastic in appearance. During decidualization this cell may differentiate into a decidual stromal cell." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T09:50:04Z" ; oboInOwl:hasDbXref "CALOHA:TS-1266", "FMA:86490" ; oboInOwl:hasExactSynonym "endometrial stromal cell", "endometrial stromal fibroblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell of endometrium" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002337 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002388 ; owl:someValuesFrom obo:CL_2000002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ] . obo:CL_0002257 obo:IAO_0000115 "An epithelial cell of thyroid gland." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T01:46:51Z" ; oboInOwl:hasDbXref "FMA:256167", "MESH:D000072637" ; a owl:Class ; rdfs:label "epithelial cell of thyroid gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:CL_0002258 obo:IAO_0000115 "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T01:50:08Z" ; oboInOwl:hasDbXref "BTO:0003736", "CALOHA:TS-1285", "FMA:68782" ; oboInOwl:hasExactSynonym "follicular cell of thyroid gland", "principal cell of thyroid gland", "thyroid gland follicular cell" ; a owl:Class ; rdfs:label "thyroid follicular cell" ; rdfs:subClassOf obo:CL_0002257 . obo:CL_0002260 obo:IAO_0000115 "An epithelial cell of the parathyroid gland." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T02:29:38Z" ; oboInOwl:hasDbXref "FMA:70547" ; a owl:Class ; rdfs:label "epithelial cell of parathyroid gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:CL_0002261 obo:IAO_0000115 "An endothelial cell found in the mucosa associated with the facial skeleton." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-14T10:40:12Z" ; oboInOwl:hasDbXref "FMA:70627" ; a owl:Class ; rdfs:label "endothelial cell of viscerocranial mucosa" ; rdfs:subClassOf obo:CL_0002076 . obo:CL_0002262 obo:IAO_0000115 "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-14T10:57:26Z" ; oboInOwl:hasDbXref "FMA:63134" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of sinusoid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003909 ] ) ] . obo:CL_0002264 obo:IAO_0000115 "A type of enteroendocrine cell found in the stomach that secretes glucagon." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T10:54:42Z" ; oboInOwl:hasDbXref "FMA:83411" ; a owl:Class ; rdfs:label "type A cell of stomach" ; rdfs:subClassOf obo:CL_0002067 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_0002265 obo:IAO_0000115 "A D cell located in the colon." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T11:37:35Z" ; oboInOwl:hasDbXref "FMA:268744" ; oboInOwl:hasExactSynonym "colon D-cell", "colonic delta cell", "delta cell of colon" ; a owl:Class ; rdfs:label "type D cell of colon" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0002658 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0002266 obo:IAO_0000115 "A type D cell of the small intestine." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T01:34:22Z" ; oboInOwl:hasDbXref "FMA:268736" ; oboInOwl:hasExactSynonym "delta cell of small intestine", "small intestine D-cell", "small intestine delta cell" ; a owl:Class ; rdfs:label "type D cell of small intestine" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0002254 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0002267 obo:IAO_0000115 "A type D cell found in the stomach." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T01:36:03Z" ; oboInOwl:hasDbXref "FMA:83410" ; oboInOwl:hasExactSynonym "delta cell of stomach", "stomach D-cell", "stomach delta cell" ; a owl:Class ; rdfs:label "type D cell of stomach" ; rdfs:subClassOf obo:CL_0000502, obo:CL_0002659 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_0002274 obo:IAO_0000115 "A cell type that secretes histamine." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T03:04:42Z" ; a owl:Class ; rdfs:label "histamine secreting cell" ; rdfs:subClassOf obo:CL_0000457 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001821 ] ) ] . obo:CL_0002275 obo:IAO_0000115 "A PP cell located in the islets of the pancreas." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-10T03:30:31Z" ; oboInOwl:hasDbXref "BTO:0000805", "FMA:70588", "MESH:D050418" ; oboInOwl:hasExactSynonym "PP cell of pancreatic islet", "PP-cell of pancreatic islet", "pancreatic polypeptide-secreting cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell." ; rdfs:label "pancreatic PP cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0002293 obo:IAO_0000115 "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-13T02:34:22Z" ; oboInOwl:hasDbXref "CALOHA:TS-1040", "FMA:72208" ; oboInOwl:hasExactSynonym "epithelial cell of thymus gland", "epithelial reticular cell", "epithelial reticular cell of thymus", "thymic epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:CL_0002294 obo:IAO_0000115 "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-13T02:37:23Z" ; oboInOwl:hasDbXref "FMA:72209" ; oboInOwl:hasExactSynonym "subcapsular thymic epithelial cell" ; a owl:Class ; rdfs:label "type-1 epithelial cell of thymus" ; rdfs:subClassOf obo:CL_0002364 . obo:CL_0002308 obo:IAO_0000115 "An epithelial cell of a skin gland." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-14T12:00:07Z" ; oboInOwl:hasDbXref "FMA:70657" ; oboInOwl:hasExactSynonym "epithelial cell of gland of skin" ; a owl:Class ; rdfs:label "epithelial cell of skin gland" ; rdfs:subClassOf obo:CL_0002159 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002419 ] ) ] . obo:CL_0002312 obo:IAO_0000115 "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-14T02:33:09Z" ; oboInOwl:hasDbXref "FMA:83095", "MESH:D052683" ; oboInOwl:hasExactSynonym "somatotrope", "somatotropic cell", "somatrophic cell" ; a owl:Class ; rdfs:label "somatotroph" ; rdfs:subClassOf obo:CL_0000295, obo:CL_0000638 . obo:CL_0002313 obo:IAO_0000115 "An ecto-epithelial cell of the prostate gland that secretes hormones." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-14T03:01:58Z" ; oboInOwl:hasDbXref "CALOHA:TS-1280", "FMA:74390", "FMA:86774" ; oboInOwl:hasExactSynonym "glandular cell of prostate", "neuro-epithelial cell of prostate gland" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endocrine-paracrine cell of prostate gland" ; rdfs:subClassOf obo:CL_0000150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002159 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:CL_0002319 obo:IAO_0000115 "A cell that is part of the nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-15T01:34:57Z" ; oboInOwl:hasDbXref "CALOHA:TS-2040", "FMA:70333" ; a owl:Class ; rdfs:label "neural cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:CL_0002320 obo:IAO_0000115 "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-15T03:01:54Z" ; oboInOwl:hasDbXref "CALOHA:TS-2096", "FMA:63875", "MESH:D003239" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "connective tissue cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] ) ] . obo:CL_0002321 obo:IAO_0000115 "A cell of the embryo." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-15T03:39:21Z" ; oboInOwl:hasDbXref "CALOHA:TS-0263", "FMA:82840", "FMA:82841", "WBbt:0007028" ; a owl:Class ; rdfs:label "embryonic cell (metazoa)" ; rdfs:subClassOf obo:CL_0000548 . obo:CL_0002323 obo:IAO_0000115 "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T10:13:37Z" ; oboInOwl:hasDbXref "BTO:0000066" ; a owl:Class ; rdfs:label "amniocyte" ; rdfs:subClassOf obo:CL_0000349 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000349 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000173 ] ) ] . obo:CL_0002325 obo:IAO_0000115 "The milk-producing cell of the alveolar unit that emerges during pregnancy." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T01:30:57Z" ; oboInOwl:hasDbXref "FMA:74506", "FMA:79866" ; oboInOwl:hasExactSynonym "epithelial cell of lactiferous gland", "luminal cell of alveolus of lactiferous gland", "mammary alveolar epithelial cell", "mammary gland alveolar epithelial cell" ; a owl:Class ; rdfs:label "mammary alveolar cell" ; rdfs:subClassOf obo:CL_0000314, obo:CL_0002159 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003214 ] ) ] . obo:CL_0002327 obo:IAO_0000115 "An epithelial cell of the mammary gland." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T01:49:37Z" ; oboInOwl:hasDbXref "BTO:0004300" ; oboInOwl:hasExactSynonym "breast epithelial cell", "mammary epithelial cell" ; a owl:Class ; rdfs:label "mammary gland epithelial cell" ; rdfs:subClassOf obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_0002328 obo:IAO_0000115 "An epithelial cell of the bronchus." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T02:00:00Z" ; oboInOwl:hasDbXref "BTO:0002922" ; a owl:Class ; rdfs:label "bronchial epithelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_0002332 obo:IAO_0000115 "A ciliated cell of the bronchus." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T02:21:12Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ciliated cell of the bronchus" ; rdfs:subClassOf obo:CL_0002145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000064 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_0002333 obo:IAO_0000115 "A fat cell derived from a neural crest cell." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T02:25:25Z" ; a owl:Class ; rdfs:label "neural crest derived fat cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] ) ] . obo:CL_0002336 obo:IAO_0000115 "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T02:52:54Z" ; a owl:Class ; rdfs:label "buccal mucosa cell" ; rdfs:subClassOf obo:CL_0002261 . obo:CL_0002339 obo:IAO_0000115 "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T03:21:06Z" ; oboInOwl:hasExactSynonym "CD133-positive prostate epithelial cell" ; a owl:Class ; rdfs:label "prostate stem cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002341 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002341 obo:IAO_0000115 "An undifferentiated cell of the prostate epithelium that lacks secretory activity." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-20T03:34:10Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "basal cell of prostate epithelium" ; rdfs:subClassOf obo:CL_0002231 . obo:CL_0002350 obo:IAO_0000115 "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-21T04:33:05Z" ; oboInOwl:hasDbXref "FMA:75621" ; oboInOwl:hasExactSynonym "endocardial endothelial cell", "endothelial cell of endocardium" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endocardial cell" ; rdfs:subClassOf obo:CL_0000115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002165 ] ) ] . obo:CL_0002351 obo:IAO_0000115 "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-21T04:41:06Z" ; oboInOwl:hasExactSynonym "pancreatic endocrine progenitor", "pancreatic islet progenitor cell" ; a owl:Class ; rdfs:label "progenitor cell of endocrine pancreas" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0011026 . obo:CL_0002352 obo:IAO_0000115 "A hematopoietic stem cell that exists during embryogenesis." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-22T09:05:13Z" ; a owl:Class ; rdfs:label "gestational hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0000037 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:CL_0002353 obo:IAO_0000115 "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-22T09:08:32Z" ; a owl:Class ; rdfs:label "fetal liver hematopoietic progenitor cell" ; rdfs:subClassOf obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002352 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001308 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001896 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002354 obo:IAO_0000115 "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-22T09:08:34Z" ; oboInOwl:hasExactSynonym "hemangioblast precursor" ; a owl:Class ; rdfs:label "yolk sac hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002352, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001040 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002352 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042611 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0002359 obo:IAO_0000115 "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-22T10:30:02Z" ; a owl:Class ; rdfs:label "placental hematopoietic stem cell" ; rdfs:subClassOf obo:CL_0002352 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0002363 obo:IAO_0000115 "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-22T01:57:40Z" ; oboInOwl:hasExactSynonym "corneal fibroblast", "corneal keratocyte" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "keratocyte" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ] ) ] . obo:CL_0002364 obo:IAO_0000115 "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-23T03:17:12Z" ; oboInOwl:hasDbXref "BTO:0004562" ; oboInOwl:hasExactSynonym "cTEC" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cortical thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002293 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002123 ] ) ] . obo:CL_0002365 obo:IAO_0000115 "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-23T03:17:14Z" ; oboInOwl:hasDbXref "BTO:0004563" ; oboInOwl:hasExactSynonym "mTEC" ; a owl:Class ; rdfs:label "medullary thymic epithelial cell" ; rdfs:subClassOf obo:CL_0002293 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002124 ] ) ] . obo:CL_0002367 obo:IAO_0000115 "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-23T04:18:50Z" ; oboInOwl:hasExactSynonym "trabeculocyte" ; a owl:Class ; rdfs:label "trabecular meshwork cell" ; rdfs:subClassOf obo:CL_0000115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005969 ] ) ] . obo:CL_0002368 obo:IAO_0000115 "An endo-epithelial cell of the respiratory tract." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-23T04:38:49Z" ; oboInOwl:hasDbXref "BTO:0004533" ; oboInOwl:hasExactSynonym "airway epithelial cell" ; a owl:Class ; rdfs:label "respiratory epithelial cell" ; rdfs:subClassOf obo:CL_0002076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:CL_0002370 obo:IAO_0000115 "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-23T04:42:27Z" ; oboInOwl:hasExactSynonym "respiratory mucosa goblet cells" ; a owl:Class ; rdfs:label "respiratory goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:CL_0002371 obo:IAO_0000115 "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-24T09:44:42Z" ; oboInOwl:hasDbXref "BTO:0001268", "FMA:72300", "WBbt:0008378" ; oboInOwl:inSubset ubprop:_upper_level ; a owl:Class ; rdfs:label "somatic cell" ; rdfs:subClassOf obo:CL_0000003, obo:CL_0000548 . obo:CL_0002372 obo:IAO_0000115 "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-24T01:13:01Z" ; oboInOwl:hasDbXref "FBbt:00005812" ; oboInOwl:hasExactSynonym "myotubule", "single cell sarcomere" ; a owl:Class ; rdfs:label "myotube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] . obo:CL_0002393 obo:IAO_0000115 "A monocyte that has characteristics of both patrolling and inflammatory monocytes." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-04T10:52:03Z" ; a owl:Class ; rdfs:label "intermediate monocyte" ; rdfs:subClassOf obo:CL_0000576, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000860 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0030224 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001289 ] ) ] . obo:CL_0002395 obo:IAO_0000115 "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-04T11:26:18Z" ; a owl:Class ; rdfs:comment "Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product." ; rdfs:label "Gr1-high classical monocyte" ; rdfs:subClassOf obo:CL_0000860 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000860 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001206 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002397 obo:IAO_0000115 "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-04T12:49:47Z" ; oboInOwl:hasExactSynonym "CD16+ monocyte" ; a owl:Class ; rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+)." ; rdfs:label "CD14-positive, CD16-positive monocyte" ; rdfs:subClassOf obo:CL_0001054 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0001054 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001483 ] ) ] . obo:CL_0002398 obo:IAO_0000115 "An intermediate monocyte that is Gr1-positive, CD43-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-04T12:49:49Z" ; a owl:Class ; rdfs:label "Gr1-positive, CD43-positive monocyte" ; rdfs:subClassOf obo:CL_0002393, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000576 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002400 obo:IAO_0000115 "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-05T10:11:38Z" ; a owl:Class ; rdfs:label "fraction B/C precursor B cell" ; rdfs:subClassOf obo:CL_0000817 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000817 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0071753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001879 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002037 ] ) ] . obo:CL_0002405 obo:IAO_0000115 "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-07T02:33:39Z" ; oboInOwl:hasExactSynonym "gammadelta thymocyte", "gd thymocyte" ; a owl:Class ; rdfs:label "gamma-delta thymocyte" ; rdfs:subClassOf obo:CL_0000893 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042106 ] ) ] . obo:CL_0002419 obo:IAO_0000115 "A T cell that expresses a T cell receptor complex and has completed T cell selection." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-12T01:56:15Z" ; oboInOwl:hasExactSynonym "CD3e-positive T cell", "mature T-cell" ; oboInOwl:hasRelatedSynonym "CD3epsilon T cell" ; a owl:Class ; rdfs:label "mature T cell" ; rdfs:subClassOf obo:CL_0000084 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0002420 obo:IAO_0000115 "A T cell that has not completed T cell selection." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-12T01:56:17Z" ; oboInOwl:hasDbXref "BTO:0001372", "CALOHA:TS-1042" ; oboInOwl:hasExactSynonym "immature T-cell" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "immature T cell" ; rdfs:subClassOf obo:CL_0000084 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:CL_4030044 ; owl:someValuesFrom obo:GO_0045058 ] ) ] . obo:CL_0002421 obo:IAO_0000115 "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-15T09:24:05Z" ; a owl:Class ; rdfs:label "nucleated reticulocyte" ; rdfs:subClassOf obo:CL_0000558 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000558 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002505 ] ) ] . obo:CL_0002422 obo:IAO_0000115 "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-15T09:24:08Z" ; oboInOwl:hasDbXref "CALOHA:TS-0864", "FMA:66785" ; a owl:Class ; rdfs:label "enucleated reticulocyte" ; rdfs:subClassOf obo:CL_0000558 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] . obo:CL_0002423 obo:IAO_0000115 "A DN2 thymocyte that is Kit-hi." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T10:12:05Z" ; a owl:Class ; rdfs:comment "Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2a thymocyte" ; rdfs:subClassOf obo:CL_0000806 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000806 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002424 obo:IAO_0000115 "A DN2 thymocyte that is Kit-low." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T10:12:08Z" ; a owl:Class ; rdfs:comment "Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ; rdfs:label "DN2b thymocyte" ; rdfs:subClassOf obo:CL_0000806, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002423 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000806 [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002425 obo:IAO_0000115 "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T01:16:24Z" ; oboInOwl:hasExactSynonym "ETP", "preT.ETP.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative." ; rdfs:label "early T lineage precursor" ; rdfs:subClassOf obo:CL_0000827 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000827 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001380 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001869 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] ) ] . obo:CL_0002427 obo:IAO_0000115 "A double-positive, alpha-beta thymocyte that is small and not proliferating." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T01:59:06Z" ; oboInOwl:hasExactSynonym "T.DP.sm.Th" ; a owl:Class ; rdfs:label "resting double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000587 ] ) ] . obo:CL_0002428 obo:IAO_0000115 "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T01:59:11Z" ; oboInOwl:hasExactSynonym "T.DPb.Th", "activated double-positive thymocyte" ; a owl:Class ; rdfs:label "double-positive blast" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002427 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0008283 ] ) ] . obo:CL_0002429 obo:IAO_0000115 "A double-positive thymocyte that is CD69-positive and has begun positive selection." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:11:52Z" ; oboInOwl:hasExactSynonym "T.DP69+.Th" ; a owl:Class ; rdfs:label "CD69-positive double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002428 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002430 obo:IAO_0000115 "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:29:19Z" ; oboInOwl:hasExactSynonym "T.4int8+.Th", "T_4int8+_Th" ; a owl:Class ; rdfs:label "CD4-intermediate, CD8-positive double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002429 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001004 ] ) ] . obo:CL_0002431 obo:IAO_0000115 "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:29:23Z" ; oboInOwl:hasExactSynonym "T.4+8int.Th", "T_4+8int_Th" ; a owl:Class ; rdfs:label "CD4-positive, CD8-intermediate double-positive thymocyte" ; rdfs:subClassOf obo:CL_0000809, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002429 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000809 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0043368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0002432 obo:IAO_0000115 "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:43:52Z" ; oboInOwl:hasExactSynonym "CD24-positive, CD4 single-positive semimature thymocyte", "T.4SP24int.Th" ; a owl:Class ; rdfs:comment "Described in the immgene database as being CD24-intermediate." ; rdfs:label "CD24-positive, CD4 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000810, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002433 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000810 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002433 obo:IAO_0000115 "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:46:02Z" ; oboInOwl:hasExactSynonym "T.4SP69+.Th", "intermediate CD4-single-positive" ; a owl:Class ; rdfs:label "CD69-positive, CD4-positive single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000810, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002431 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000810 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002434 obo:IAO_0000115 "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:59:10Z" ; oboInOwl:hasExactSynonym "CD24-positive, CD8 single-positive semimature thymocyte", "T.8SP24int.Th" ; a owl:Class ; rdfs:comment "Described in the immgene database as being CD24-intermediate." ; rdfs:label "CD24-positive, CD8 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000811, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002435 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000811 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002435 obo:IAO_0000115 "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T02:59:14Z" ; oboInOwl:hasExactSynonym "T.8SP69+.Th", "intermediate CD8-single-positive" ; a owl:Class ; rdfs:label "CD69-positive, CD8-positive single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000811, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002430 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000811 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] ) ] . obo:CL_0002436 obo:IAO_0000115 "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T03:31:19Z" ; oboInOwl:hasRelatedSynonym "T.4SP24-.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mature CD4 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000624, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002432 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002437 obo:IAO_0000115 "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-21T03:51:50Z" ; oboInOwl:hasExactSynonym "T.8SP24-.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mature CD8 single-positive thymocyte" ; rdfs:subClassOf obo:CL_0000625, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002434 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000001932 ] ) ] . obo:CL_0002453 obo:IAO_0000115 "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." ; dcterms:contributor , ; oboInOwl:creation_date "2010-11-10T02:51:34Z" ; oboInOwl:hasBroadSynonym "O-2A/OPC", "O2A/OPC", "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell", "oligodendrocyte/type-2 astrocyte progenitor cell" ; oboInOwl:hasDbXref "MESH:D000073637" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." ; rdfs:label "oligodendrocyte precursor cell" ; rdfs:subClassOf [ a owl:Class ; owl:intersectionOf (obo:CL_0000123 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000339 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] . obo:CL_0002454 obo:IAO_0000115 "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-22T01:10:28Z" ; oboInOwl:hasExactSynonym "DC.8-4-11b+", "spleen double-negative dendritic cell" ; a owl:Class ; rdfs:label "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0002465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002465 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002457 obo:IAO_0000115 "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-22T03:57:57Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epidermal Langerhans cell" ; rdfs:subClassOf obo:CL_0000453 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000453 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001014 ] ) ] . obo:CL_0002460 obo:IAO_0000115 "A conventional thymic dendritic cell that is CD8alpha-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T10:58:53Z" ; oboInOwl:hasExactSynonym "DC.8-.Th" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "CD8alpha-negative thymic conventional dendritic cell" ; rdfs:subClassOf obo:CL_0000941 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000941 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] ) ] . obo:CL_0002462 obo:IAO_0000115 "A F4/80-negative dendritic cell located in adipose tissue." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T01:38:21Z" ; a owl:Class ; rdfs:label "adipose dendritic cell" ; rdfs:subClassOf obo:CL_0000990, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] ) ] . obo:CL_0002463 obo:IAO_0000115 "An adipose dendritic cell that is SIRPa-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T01:40:44Z" ; oboInOwl:hasExactSynonym "DC.SIRPa+.Ad" ; a owl:Class ; rdfs:label "SIRPa-positive adipose dendritic cell" ; rdfs:subClassOf obo:CL_0002462 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002464 obo:IAO_0000115 "An adipose dendritic cell that is SIRPa-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T01:40:46Z" ; oboInOwl:hasExactSynonym "DC.SIRPa-.Ad" ; a owl:Class ; rdfs:label "SIRPa-negative adipose dendritic cell" ; rdfs:subClassOf obo:CL_0002462 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002465 obo:IAO_0000115 "A conventional dendritic cell that expresses CD11b (ITGAM)." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T01:50:05Z" ; a owl:Class ; rdfs:label "CD11b-positive dendritic cell" ; rdfs:subClassOf obo:CL_0000990 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002467 obo:IAO_0000115 "A myeloid suppressor cell that is Gr1-high and CD11c-negative." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T02:15:12Z" ; oboInOwl:hasExactSynonym "MDS.Gr1hi" ; a owl:Class ; rdfs:label "Gr1-high myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000889 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000889 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002468 obo:IAO_0000115 "A myeloid suppressor cell that is Gr1-low and CD11c-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T02:19:43Z" ; oboInOwl:hasExactSynonym "MDS.Gr1lo" ; a owl:Class ; rdfs:label "Gr1-low myeloid suppressor cell" ; rdfs:subClassOf obo:CL_0000889 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000889 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015016 ; owl:someValuesFrom obo:PR_000002980 ] ) ] . obo:CL_0002469 obo:IAO_0000115 "Gr1-high monocyte that lacks MHC-II receptor complex." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T03:27:12Z" ; oboInOwl:hasExactSynonym "Mo.6C+II-" ; a owl:Class ; rdfs:label "MHC-II-negative classical monocyte" ; rdfs:subClassOf obo:CL_0002395 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002395 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002470 obo:IAO_0000115 "Gr1-high monocyte that has a MHC-II receptor complex." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T03:30:21Z" ; oboInOwl:hasExactSynonym "Mo.6c+II" ; a owl:Class ; rdfs:label "MHC-II-positive classical monocyte" ; rdfs:subClassOf obo:CL_0002395 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002395 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002474 obo:IAO_0000115 "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T04:00:52Z" ; a owl:Class ; rdfs:label "lymphoid MHC-II-negative classical monocyte" ; rdfs:subClassOf obo:CL_0002469 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002469 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0015015 ; owl:someValuesFrom obo:PR_000001012 ] ) ] . obo:CL_0002476 obo:IAO_0000115 "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T04:19:25Z" ; oboInOwl:hasDbXref "BTO:0004732" ; oboInOwl:hasRelatedSynonym "MF.BM" ; a owl:Class ; rdfs:label "bone marrow macrophage" ; rdfs:subClassOf obo:CL_0000864, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001014 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002980 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002062 ] ) ] . obo:CL_0002477 obo:IAO_0000115 "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T04:31:28Z" ; a owl:Class ; rdfs:label "adipose macrophage" ; rdfs:subClassOf obo:CL_0000864 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000864 [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001968 ] ) ] . obo:CL_0002478 obo:IAO_0000115 "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T04:40:50Z" ; oboInOwl:hasExactSynonym "MF.Autofl.Ad" ; a owl:Class ; rdfs:label "F4/80-negative adipose macrophage" ; rdfs:subClassOf obo:CL_0002477 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002477 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] ) ] . obo:CL_0002479 obo:IAO_0000115 "An adipose macrophage that does not express MHC-II but is F4/80-positive." ; dcterms:contributor ; oboInOwl:creation_date "2010-11-23T04:35:53Z" ; oboInOwl:hasExactSynonym "MF.F480+.Ad" ; a owl:Class ; rdfs:label "F4/80-positive adipose macrophage" ; rdfs:subClassOf obo:CL_0002477 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002477 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001813 ] ) ] . obo:CL_0002480 obo:IAO_0000115 "A goblet cell located in the nasal epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-03T03:03:02Z" ; oboInOwl:hasDbXref "MP:0002262" ; a owl:Class ; rdfs:label "nasal mucosa goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] . obo:CL_0002482 obo:IAO_0000115 "A melanocyte that produces pigment in the dermis." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:05Z" ; a owl:Class ; rdfs:label "dermal melanocyte" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0002483 obo:IAO_0000115 "A melanocyte that produces pigment within the hair follicle." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:09Z" ; a owl:Class ; rdfs:label "hair follicle melanocyte" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:CL_0002484 obo:IAO_0000115 "A melanocyte that produces pigment in the epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-03T03:17:14Z" ; a owl:Class ; rdfs:comment "The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium." ; rdfs:label "epithelial melanocyte" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ) ] . obo:CL_0002485 obo:IAO_0000115 "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-03T03:25:32Z" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "retinal melanocyte" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_0002489 obo:IAO_0000115 "A thymocyte that lacks expression of CD4 and CD8." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-06T03:03:38Z" ; oboInOwl:hasExactSynonym "CD4-CD8- T cell", "double negative T cell" ; a owl:Class ; rdfs:comment "These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes." ; rdfs:label "double negative thymocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000893 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000025402 ] ) ] . obo:CL_0002491 obo:IAO_0000115 "A specialized cell involved in auditory sensory perception." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-06T03:18:43Z" ; a owl:Class ; rdfs:label "auditory epithelial cell" ; rdfs:subClassOf obo:CL_0000098 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050910 ] ) ] . obo:CL_0002494 obo:IAO_0000115 "A cell located in the heart, including both muscle and non muscle cells." ; dcterms:contributor ; oboInOwl:creation_date "2010-12-07T09:37:22Z" ; oboInOwl:hasDbXref "BTO:0001539", "CALOHA:TS-0115", "FMA:83808", "FMA:84791" ; oboInOwl:hasExactSynonym "heart cell" ; a owl:Class ; rdfs:comment "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ; rdfs:label "cardiocyte" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007100 ] ) ] . obo:CL_0002503 obo:IAO_0000115 "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" ; dcterms:contributor ; oboInOwl:creation_date "2010-12-07T04:03:56Z" ; oboInOwl:hasDbXref "BTO:0002441", "FMA:84639" ; a owl:Class ; rdfs:label "adventitial cell" ; rdfs:subClassOf obo:CL_0000630, obo:CL_0002320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005742 ] ) ] . obo:CL_0002504 obo:IAO_0000115 "A smooth muscle cell of the intestine." ; dcterms:contributor ; oboInOwl:creation_date "2011-01-17T03:39:38Z" ; oboInOwl:hasExactSynonym "intestinal smooth muscle cell" ; a owl:Class ; rdfs:label "enteric smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:CL_0002507 obo:IAO_0000115 "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." ; dcterms:contributor ; oboInOwl:creation_date "2011-01-21T01:57:00Z" ; a owl:Class ; rdfs:label "langerin-positive lymph node dendritic cell" ; rdfs:subClassOf obo:CL_0000990 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000990 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001004 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:GO_0042613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000001293 ] ) ] . obo:CL_0002518 obo:IAO_0000115 "An epithelial cell of the kidney." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-08T10:46:34Z" ; oboInOwl:hasDbXref "KUPO:0001019" ; a owl:Class ; rdfs:label "kidney epithelial cell" ; rdfs:subClassOf obo:CL_1000497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_0002521 obo:IAO_0000115 "A fat cell that is part of subcutaneous adipose tissue." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-21T02:51:22Z" ; oboInOwl:hasExactSynonym "subcutaneous adipocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "subcutaneous fat cell" ; rdfs:subClassOf obo:CL_0000136 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002190 ] ) ] . obo:CL_0002535 obo:IAO_0000115 "An epithelial cell of the cervix." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-24T08:20:08Z" ; oboInOwl:hasExactSynonym "cervical canal epithelial cell", "cervical canal of uterus epithelial cell", "cervix epithelial cell", "cervix of uterus epithelial cell", "epithelial cell of cervical canal", "epithelial cell of cervical canal of uterus", "epithelial cell of cervix of uterus", "epithelial cell of neck of uterus", "epithelial cell of uterine cervix", "neck of uterus epithelial cell", "uterine cervix epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of cervix" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_0002536 obo:IAO_0000115 "An epithelial cell that is part of the amnion." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T12:38:01Z" ; oboInOwl:hasExactSynonym "amniotic epithelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of amnion" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] . obo:CL_0002537 obo:IAO_0000115 "A mesenchymal stem cell of the amnion membrane." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T12:44:24Z" ; oboInOwl:hasExactSynonym "amniotic membrane stem cell" ; a owl:Class ; rdfs:label "amnion mesenchymal stem cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] . obo:CL_0002538 obo:IAO_0000115 "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T01:20:20Z" ; oboInOwl:hasExactSynonym "small bile duct cholangiocyte" ; a owl:Class ; rdfs:label "intrahepatic cholangiocyte" ; rdfs:subClassOf obo:CL_1000488 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004823 ] ) ] . obo:CL_0002539 obo:IAO_0000115 "A smooth muscle cell of the aorta." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T01:42:12Z" ; oboInOwl:hasDbXref "BTO:0004577" ; a owl:Class ; rdfs:label "aortic smooth muscle cell" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004178 ] ) ] . obo:CL_0002540 obo:IAO_0000115 "A mesenchymal stem cell that is part of the bone marrow." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T01:47:47Z" ; a owl:Class ; rdfs:label "mesenchymal stem cell of the bone marrow" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0002541 obo:IAO_0000115 "A mesenchymal stem cell of the chorionic membrane." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T03:04:35Z" ; a owl:Class ; rdfs:label "chorionic membrane mesenchymal stem cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ) ] . obo:CL_0002543 obo:IAO_0000115 "An endothelial cell that is part of the vein." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T03:48:11Z" ; oboInOwl:hasDbXref "FMA:62104", "KUPO:0001099" ; oboInOwl:hasExactSynonym "endothelial cell of vein", "venous endothelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vein endothelial cell" ; rdfs:subClassOf obo:CL_0000071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:CL_0002546 obo:IAO_0000115 "An endothelial progenitor cell that participates in angiogenesis during development." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T04:20:39Z" ; a owl:Class ; rdfs:comment "See CL:0002619." ; rdfs:label "embryonic blood vessel endothelial progenitor cell" ; rdfs:subClassOf obo:CL_0000222, obo:CL_0002371 . obo:CL_0002547 obo:IAO_0000115 "A fibroblast of the aortic adventitia." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T04:43:41Z" ; a owl:Class ; rdfs:label "fibroblast of the aortic adventitia" ; rdfs:subClassOf obo:CL_1000306 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000306 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004664 ] ) ] . obo:CL_0002548 obo:IAO_0000115 "A fibroblast that is part of the heart." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T04:57:44Z" ; oboInOwl:hasExactSynonym "cardiac fibroblast" ; a owl:Class ; rdfs:label "fibroblast of cardiac tissue" ; rdfs:subClassOf obo:CL_0000057, obo:CL_0002494 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0002549 obo:IAO_0000115 "A fibroblast that is part of the choroid plexus." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:01:39Z" ; a owl:Class ; rdfs:label "fibroblast of choroid plexus" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:CL_0002550 obo:IAO_0000115 "A fibroblast that is part of the conjuctiva of the eye." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:03:44Z" ; a owl:Class ; rdfs:label "fibroblast of the conjunctiva" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:CL_0002551 dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:05:33Z" ; a owl:Class ; rdfs:label "fibroblast of dermis" ; rdfs:subClassOf obo:CL_0002620 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0002552 dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:09:12Z" ; a owl:Class ; rdfs:label "fibroblast of gingiva" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] . obo:CL_0002553 obo:IAO_0000115 "A fibroblast that is part of lung." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:11:03Z" ; oboInOwl:hasDbXref "BTO:0000764", "CALOHA:TS-0575" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "fibroblast of lung" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_0002554 obo:IAO_0000115 "A fibroblast of the lymphatic system." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:16:18Z" ; a owl:Class ; rdfs:label "fibroblast of lymphatic vessel" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0002555 obo:IAO_0000115 "A fibroblast that is part of the mammary gland." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:18:38Z" ; a owl:Class ; rdfs:label "fibroblast of mammary gland" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_0002556 obo:IAO_0000115 "A fibroblast of the periodontium." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:19:48Z" ; a owl:Class ; rdfs:label "fibroblast of periodontium" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001758 ] ) ] . obo:CL_0002557 obo:IAO_0000115 "A fibroblast of pulmonary artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-28T05:22:27Z" ; a owl:Class ; rdfs:label "fibroblast of pulmonary artery" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_0002559 obo:IAO_0000115 "An animal cell that is part of a hair follicle." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T04:11:01Z" ; a owl:Class ; rdfs:label "hair follicle cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002371 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:CL_0002563 obo:IAO_0000115 "An epithelial cell of the intestine." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T05:18:31Z" ; a owl:Class ; rdfs:label "intestinal epithelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:CL_0002564 obo:IAO_0000115 "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-02T02:12:23Z" ; a owl:Class ; rdfs:label "nucleus pulposus cell of intervertebral disc" ; rdfs:subClassOf obo:CL_0002320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002242 ] ) ] . obo:CL_0002569 obo:IAO_0000115 "A mesenchymal stem cell of the umbilical cord." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T09:55:12Z" ; a owl:Class ; rdfs:label "mesenchymal stem cell of umbilical cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003422 ] ) ] . obo:CL_0002570 obo:IAO_0000115 "A mesenchymal stem cell of adipose tissue." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T09:57:17Z" ; oboInOwl:hasExactSynonym "mesenchymal stem cell of adipose" ; a owl:Class ; rdfs:label "mesenchymal stem cell of adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] . obo:CL_0002571 obo:IAO_0000115 "A mesenchymal stem cell of liver." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T09:58:51Z" ; a owl:Class ; rdfs:label "hepatic mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_0002572 obo:IAO_0000115 "A mesenchymal stem cell of the vertebrae." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-01T10:40:27Z" ; a owl:Class ; rdfs:label "vertebral mesenchymal stem cell" ; rdfs:subClassOf obo:CL_0000134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] . obo:CL_0002574 obo:IAO_0000115 "A stromal cell of the pancreas." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-02T02:40:41Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stromal cell of pancreas" ; rdfs:subClassOf obo:CL_0000499 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0002575 obo:IAO_0000115 "A pericyte of the central nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-02T02:54:18Z" ; a owl:Class ; rdfs:label "central nervous system pericyte" ; rdfs:subClassOf obo:CL_0000669 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_0002577 obo:IAO_0000115 "An epithelial cell of the placenta." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-02T03:21:30Z" ; a owl:Class ; rdfs:label "placental epithelial cell" ; rdfs:subClassOf obo:CL_0000349, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0002584 obo:IAO_0000115 "An epithelial cell of the kidney cortex." ; oboInOwl:hasDbXref "KUPO:0001016" ; a owl:Class ; rdfs:label "renal cortical epithelial cell" ; rdfs:subClassOf obo:CL_0002518, obo:CL_0002681 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002518 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:CL_0002585 obo:IAO_0000115 "A blood vessel endothelial cell that is part of the retina." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T03:28:27Z" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal blood vessel endothelial cell" ; rdfs:subClassOf obo:CL_0000071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_0002586 obo:IAO_0000115 "An epithelial cell of the retinal pigmented epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T03:37:09Z" ; oboInOwl:hasDbXref "BTO:0004910", "FMA:75802" ; oboInOwl:inSubset cl:eye_upper_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "retinal pigment epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0000149, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001782 ] ) ] . obo:CL_0002589 obo:IAO_0000115 "A smooth muscle cell of the bachiocephalic vasculature." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:00:58Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the brachiocephalic vasculature" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001529 ] ) ] . obo:CL_0002590 obo:IAO_0000115 "A vascular associated smooth muscle cell of the brain vasculature." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:20Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the brain vasculature" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_0002591 obo:IAO_0000115 "A smooth muscle of the pulmonary artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:28Z" ; oboInOwl:hasDbXref "BTO:0003336" ; a owl:Class ; rdfs:label "smooth muscle cell of the pulmonary artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_0002592 obo:IAO_0000115 "A smooth muscle cell of the coronary artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:34Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of the coronary artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] . obo:CL_0002593 obo:IAO_0000115 "A smooth muscle of the internal thoracic artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:41Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the internal thoracic artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002456 ] ) ] . obo:CL_0002594 obo:IAO_0000115 "A smooth muscle cell of the umbilical artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:48Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the umbilical artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:CL_0002595 obo:IAO_0000115 "A smooth muscle cell of the subclavian artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:52Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the subclavian artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ] ) ] . obo:CL_0002596 obo:IAO_0000115 "Smooth muscle cell of the carotid artery." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:01:56Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the carotid artery" ; rdfs:subClassOf obo:CL_0000359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005396 ] ) ] . obo:CL_0002597 obo:IAO_0000115 "A smooth muscle cell of the bladder." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:43:24Z" ; oboInOwl:hasDbXref "KUPO:0001122" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of bladder" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_0002598 dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:46:39Z" ; oboInOwl:hasDbXref "BTO:0004402" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchial smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_0002599 obo:IAO_0000115 "A smooth muscle cell of the esophagus." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:48:17Z" ; a owl:Class ; rdfs:label "smooth muscle cell of the esophagus" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:CL_0002600 obo:IAO_0000115 "A smooth muscle cell of the trachea." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:50:28Z" ; a owl:Class ; rdfs:label "smooth muscle cell of trachea" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_0002601 obo:IAO_0000115 "A smooth muscle cell of the uterus." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T05:53:28Z" ; a owl:Class ; rdfs:label "uterine smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_0002602 dcterms:contributor ; oboInOwl:creation_date "2011-03-06T06:50:53Z" ; oboInOwl:hasExactSynonym "anulus pulposus cell" ; a owl:Class ; rdfs:label "annulus pulposus cell" ; rdfs:subClassOf obo:CL_0002320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004715 ] ) ] . obo:CL_0002603 obo:IAO_0000115 "An astrocyte of the cerebellum." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:27Z" ; a owl:Class ; rdfs:label "astrocyte of the cerebellum" ; rdfs:subClassOf obo:CL_0000127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:CL_0002604 obo:IAO_0000115 "An astrocyte that is part of the hippocampus." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:33Z" ; oboInOwl:hasExactSynonym "astrocyte of the hippocampal formation", "astrocyte of the hippocampus" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "hippocampal astrocyte" ; rdfs:subClassOf obo:CL_0000127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_0002605 obo:IAO_0000115 "An astrocyte of the cerebral cortex." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T06:57:36Z" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "astrocyte of the cerebral cortex" ; rdfs:subClassOf obo:CL_0000127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0002606 obo:IAO_0000115 "An astrocyte of the spinal cord." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:11:26Z" ; a owl:Class ; rdfs:label "astrocyte of the spinal cord" ; rdfs:subClassOf obo:CL_0000127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_0002607 obo:IAO_0000115 "A neural crest cell that gives rise to cells of the enteric nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:24:35Z" ; a owl:Class ; rdfs:label "migratory enteric neural crest cell" ; rdfs:subClassOf obo:CL_0000333 . obo:CL_0002608 obo:IAO_0000115 "A neuron with a soma found in the hippocampus." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:31:49Z" ; a owl:Class ; rdfs:label "hippocampal neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_0002610 obo:IAO_0000115 "A neuron of the raphe nuclei." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:42:06Z" ; a owl:Class ; rdfs:label "raphe nuclei neuron" ; rdfs:subClassOf obo:CL_0000117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0004684 ] ) ] . obo:CL_0002612 obo:IAO_0000115 "A neuron of the ventral spinal cord." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:46:03Z" ; a owl:Class ; rdfs:label "neuron of the ventral spinal cord" ; rdfs:subClassOf obo:CL_0000117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002257 ] ) ] . obo:CL_0002613 obo:IAO_0000115 "A neuron of the striatum." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:47:12Z" ; a owl:Class ; rdfs:label "striatum neuron" ; rdfs:subClassOf obo:CL_0000117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002435 ] ) ] . obo:CL_0002614 obo:IAO_0000115 "A neuron of the substantia nigra." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-06T07:48:42Z" ; a owl:Class ; rdfs:label "neuron of the substantia nigra" ; rdfs:subClassOf obo:CL_0000117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002038 ] ) ] . obo:CL_0002617 obo:IAO_0000115 "A fat cell that is part of the breast." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-14T10:17:07Z" ; oboInOwl:hasDbXref "CALOHA:TS-2377" ; oboInOwl:hasExactSynonym "breast adipocyte", "fat cell of breast" ; a owl:Class ; rdfs:comment "Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]" ; rdfs:label "adipocyte of breast" ; rdfs:subClassOf obo:CL_0000136 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_0002620 obo:IAO_0000115 "A fibroblast of skin." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-14T12:31:49Z" ; oboInOwl:hasDbXref "BTO:0001255", "CALOHA:TS-0935" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "skin fibroblast" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] . obo:CL_0002621 dcterms:contributor ; oboInOwl:creation_date "2011-03-14T12:46:28Z" ; a owl:Class ; rdfs:label "gingival epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001949 ] ) ] . obo:CL_0002622 obo:IAO_0000115 "A stromal cell of the prostate." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-14T02:11:10Z" ; oboInOwl:hasDbXref "BTO:0003972" ; a owl:Class ; rdfs:label "prostate stromal cell" ; rdfs:subClassOf obo:CL_0000499 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_0002623 obo:IAO_0000115 "An acinar cell of salivary gland." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-14T02:22:22Z" ; a owl:Class ; rdfs:label "acinar cell of salivary gland" ; rdfs:subClassOf obo:CL_0000622 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:CL_0002625 obo:IAO_0000115 "A cell of the seminiferous tubule epithelium." ; dcterms:contributor ; oboInOwl:creation_date "2011-03-15T11:59:23Z" ; a owl:Class ; rdfs:label "seminiferous tubule epithelial cell" ; rdfs:subClassOf obo:CL_0000077, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004813 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:CL_0002631 dcterms:contributor ; oboInOwl:creation_date "2011-06-21T12:28:55Z" ; a owl:Class ; rdfs:label "epithelial cell of upper respiratory tract" ; rdfs:subClassOf obo:CL_0002368 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 ] ) ] . obo:CL_0002632 dcterms:contributor ; oboInOwl:creation_date "2011-06-21T12:29:31Z" ; a owl:Class ; rdfs:label "epithelial cell of lower respiratory tract" ; rdfs:subClassOf obo:CL_0002368 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] . obo:CL_0002634 obo:IAO_0000115 "An epithelial cell of the anal column." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-08T12:11:38Z" ; a owl:Class ; rdfs:label "epithelial cell of anal column" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009882 ] ) ] . obo:CL_0002637 obo:IAO_0000115 "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-08T02:08:40Z" ; a owl:Class ; rdfs:label "keratinized epithelial cell of the anal canal" ; rdfs:subClassOf obo:CL_0000237, obo:CL_0002634 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:CL_0002656 obo:IAO_0000115 "A glandular epithelial cell of the endometrium." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-08T03:54:08Z" ; oboInOwl:hasDbXref "FMA:86489" ; a owl:Class ; rdfs:label "glandular cell of endometrium" ; rdfs:subClassOf obo:CL_0000150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ] . obo:CL_0002657 obo:IAO_0000115 "A glandular epithelial cell of the esophagus." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-08T03:55:57Z" ; oboInOwl:hasDbXref "FMA:86548" ; a owl:Class ; rdfs:label "glandular cell of esophagus" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0002252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:CL_0002658 obo:IAO_0000115 "A glandular epithelial cell of the large intestine." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-08T04:03:01Z" ; oboInOwl:hasDbXref "FMA:87194" ; a owl:Class ; rdfs:label "glandular cell of the large intestine" ; rdfs:subClassOf obo:CL_0000150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_0002659 obo:IAO_0000115 "A glandular epithelial cell that is part of the stomach." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-11T01:20:35Z" ; oboInOwl:hasDbXref "CALOHA:TS-1284", "FMA:86554" ; a owl:Class ; rdfs:label "glandular cell of stomach" ; rdfs:subClassOf obo:CL_0000150 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_0002663 obo:IAO_0000115 "A myocardial endocrine cell that is part of the atrium." ; dcterms:contributor ; oboInOwl:creation_date "2011-07-11T02:45:39Z" ; oboInOwl:hasDbXref "FMA:83389" ; a owl:Class ; rdfs:label "myocardial endocrine cell of atrium" ; rdfs:subClassOf obo:CL_0002074 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:CL_0002672 obo:IAO_0000115 "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." ; dcterms:contributor ; oboInOwl:creation_date "2011-08-16T02:38:01Z" ; a owl:Class ; rdfs:label "retinal progenitor cell" ; rdfs:subClassOf obo:CL_0000048, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0002673 obo:IAO_0000115 "A skeletal muscle cell that is part of the tongue." ; dcterms:contributor ; oboInOwl:creation_date "2011-08-16T03:10:02Z" ; a owl:Class ; rdfs:label "tongue muscle cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000378 ] ) ] . obo:CL_0002676 obo:IAO_0000115 "A neuroblast derived from a neural crest cell." ; dcterms:contributor ; oboInOwl:creation_date "2011-08-22T09:24:15Z" ; a owl:Class ; rdfs:label "neural crest derived neuroblast" ; rdfs:subClassOf obo:CL_0000031, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000333 ] . obo:CL_0002678 obo:IAO_0000115 "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." ; dcterms:contributor ; oboInOwl:creation_date "2011-08-25T03:17:34Z" ; a owl:Class ; rdfs:comment "Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell." ; rdfs:label "memory regulatory T cell" ; rdfs:subClassOf obo:CL_0000792, obo:CL_0000813 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:CL_0002679 obo:IAO_0000115 "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" ; dcterms:contributor ; oboInOwl:creation_date "2011-08-29T10:08:02Z" ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "natural helper lymphocyte" ; rdfs:subClassOf obo:CL_0000542 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:GO_0042105 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001002 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001012 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001013 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001020 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001084 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000001874 ] [ a owl:Restriction ; owl:onProperty obo:CL_4030046 ; owl:someValuesFrom obo:PR_000002981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002104 ; owl:someValuesFrom obo:PR_000002979 ] ) ] . obo:CL_0002680 obo:IAO_0000115 "A PP cell found in intestine." ; dcterms:contributor ; oboInOwl:creation_date "2011-09-27T11:59:01Z" ; a owl:Class ; rdfs:label "PP cell of intestine" ; rdfs:subClassOf obo:CL_0000696 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:CL_0002681 dcterms:contributor ; oboInOwl:creation_date "2011-10-25T03:49:41Z" ; a owl:Class ; rdfs:label "kidney cortical cell" ; rdfs:subClassOf obo:CL_1000497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:CL_0005000 obo:IAO_0000115 "A CNS interneuron located in the spinal cord." ; a owl:Class ; rdfs:comment "Is_a interneuron, part_of UBERON:0002240." ; rdfs:label "spinal cord interneuron" ; rdfs:subClassOf obo:CL_0000402 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_0005009 obo:IAO_0000115 "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." ; a owl:Class ; rdfs:label "renal principal cell" ; rdfs:subClassOf obo:CL_0000075, obo:CL_0002518 . obo:CL_0005012 obo:IAO_0000115 "A ciliated epithelial cell with many cilia." ; oboInOwl:hasBroadSynonym "MCC"@en, "multi-ciliated cell"@en, "multiciliated cell"@en ; oboInOwl:hasExactSynonym "multiciliated epithelial cell"@en ; a owl:Class ; rdfs:label "multi-ciliated epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] . obo:CL_0005020 obo:IAO_0000115 "Lymphatic progenitor cells." ; dcterms:contributor ; oboInOwl:creation_date "2012-01-12T04:44:34Z" ; a owl:Class ; rdfs:comment "Usually express Prox1, or prox1b." ; rdfs:label "lymphangioblast" ; rdfs:subClassOf obo:CL_0000048 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000048 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004536 ] ) ] . obo:CL_0005022 obo:IAO_0000115 "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." ; dcterms:contributor ; oboInOwl:creation_date "2012-01-12T05:21:09Z" ; oboInOwl:hasNarrowSynonym "parachordal lymphangioblast" ; a owl:Class ; rdfs:label "vascular lymphangioblast" ; rdfs:subClassOf obo:CL_0005020 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005020 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:CL_0005024 obo:IAO_0000115 "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." ; oboInOwl:hasExactSynonym "somatic motor neuron" ; a owl:Class ; rdfs:label "somatomotor neuron"@en ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0014055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002120 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0005026 obo:IAO_0000115 "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." ; a owl:Class ; rdfs:label "hepatoblast"@en ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" ; rdfs:subClassOf obo:CL_0000048 . obo:CL_0007000 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-15T01:27:01Z" ; a owl:Class ; rdfs:comment "unsure of neural crest contribution. In VSAO we have develops_from CL:0000008" ; rdfs:label "preameloblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002077 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001763 ] . obo:CL_0007001 obo:IAO_0000115 "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-15T02:51:27Z" ; oboInOwl:hasExactSynonym "scleroblast" ; a owl:Class ; rdfs:comment "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ; rdfs:label "skeletogenic cell" ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0007002 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into a cementoblast." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-15T04:37:13Z" ; a owl:Class ; rdfs:label "precementoblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ] . obo:CL_0007003 obo:IAO_0000115 "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-15T05:15:11Z" ; a owl:Class ; rdfs:label "preodontoblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000008 ] . obo:CL_0007004 obo:IAO_0000115 "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-27T08:27:35Z" ; a owl:Class ; rdfs:label "premigratory neural crest cell" ; rdfs:subClassOf obo:CL_0011012, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000133 ] . obo:CL_0007009 obo:IAO_0000115 "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-27T10:44:01Z" ; a owl:Class ; rdfs:label "prechondroblast" ; rdfs:subClassOf obo:CL_0000055, obo:CL_0000548 . obo:CL_0007011 obo:IAO_0000115 "Neuron that is part of the enteric nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2012-06-28T08:20:31Z" ; a owl:Class ; rdfs:label "enteric neuron" ; rdfs:subClassOf obo:CL_0000540, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:CL_0008000 obo:IAO_0000115 "Any muscle cell in which the fibers are not organised into sarcomeres." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "non-striated muscle cell" ; rdfs:subClassOf obo:CL_0000187 . obo:CL_0008001 obo:IAO_0000115 "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." ; a owl:Class ; rdfs:label "hematopoietic precursor cell" ; rdfs:subClassOf obo:CL_0000988 . obo:CL_0008002 obo:IAO_0000115 "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." ; oboInOwl:hasDbXref "MESH:D018485" ; a owl:Class ; rdfs:label "skeletal muscle fiber"@en ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000515 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] . obo:CL_0008007 obo:IAO_0000115 "A muscle cell that is part of some visceral muscle." ; oboInOwl:hasDbXref "FBbt:00005070" ; a owl:Class ; rdfs:label "visceral muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8600004 ] ) ] . obo:CL_0008008 obo:IAO_0000115 "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." ; a owl:Class ; rdfs:label "striated visceral muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008007 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001410 ] ) ] ) ] . obo:CL_0008009 obo:IAO_0000115 "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." ; a owl:Class ; rdfs:label "transversely striated visceral muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008007 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002478 ] ) ] ) ] . obo:CL_0008017 obo:IAO_0000115 "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." ; oboInOwl:hasBroadSynonym "myogenic precursor cell" ; a owl:Class ; rdfs:comment "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins." ; rdfs:label "adult skeletal muscle myoblast" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0008002 ] ) ] . obo:CL_0008019 obo:IAO_0000115 "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." ; oboInOwl:hasExactSynonym "mesenchyme cell" ; a owl:Class ; rdfs:label "mesenchymal cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003104 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0016477 ] . obo:CL_0008022 obo:IAO_0000115 "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." ; a owl:Class ; rdfs:label "endocardial cushion cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000569 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002062 ] ) ] . obo:CL_0008024 obo:IAO_0000115 "An endocrine cell that is part of the pancreas." ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic endocrine cell" ; rdfs:subClassOf obo:CL_0000163, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_0008028 dcterms:contributor ; oboInOwl:creation_date "2017-07-09T19:12:36Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "visual system neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007601 ] ) ] . obo:CL_0008031 obo:IAO_0000115 "An interneuron that has its soma located in the cerebral cortex." ; oboInOwl:hasExactSynonym "cerebral cortex interneuron" ; a owl:Class ; rdfs:label "cortical interneuron"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0008033 obo:IAO_0000115 "A pericyte of the decidual vasculature." ; dcterms:contributor ; oboInOwl:creation_date "2020-02-29T11:45:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "decidual perivascular cell" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "decidual pericyte"@en ; rdfs:subClassOf obo:CL_0000669 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ] ) ] . obo:CL_0008034 obo:IAO_0000115 "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." ; dcterms:contributor ; oboInOwl:creation_date "2020-02-29T17:33:55Z"^^xsd:dateTime ; oboInOwl:inSubset cl:added_for_HCA, core:human_reference_atlas ; a owl:Class ; rdfs:label "mural cell"@en ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371 . obo:CL_0008035 dcterms:contributor ; oboInOwl:creation_date "2020-02-29T17:37:00Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "microcirculation associated smooth muscle cell"@en ; rdfs:subClassOf obo:CL_0008034 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000359 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010523 ] ) ] . obo:CL_0009000 obo:IAO_0000115 "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." ; oboInOwl:hasExactSynonym "spinal sensory neuron" ; a owl:Class ; rdfs:label "sensory neuron of spinal nerve" ; rdfs:subClassOf obo:CL_0000101 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000101 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001780 ] ) ] . obo:CL_0009004 obo:IAO_0000115 "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." ; oboInOwl:hasDbXref "PMID:10702418" ; oboInOwl:inSubset cl:general_cell_types_upper_slim ; a owl:Class ; rdfs:label "retinal cell" ; rdfs:subClassOf obo:CL_0002319 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005388 ] ) ] . obo:CL_0009006 obo:IAO_0000115 "An enteroendocrine cell that is located in the small intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "small intestine enteroendocrine cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of small intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0009018 obo:IAO_0000115 "A lymphocyte that resides in the lamina propria of the large intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "lamina propria lymphocyte of large intestine" ; oboInOwl:inSubset pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymphocyte of large intestine lamina propria" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009019 obo:IAO_0000115 "A kidney cortical cell that is part of the nephrogenic zone." ; dcterms:contributor ; oboInOwl:hasExactSynonym "cortical nephrogenic niche cell", "cortical nephrogenic zone cell" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "nephrogenic zone cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009871 ] ) ] . obo:CL_0009021 obo:IAO_0000115 "A stromal cell found in the lamina propria of the large intestine." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of large intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] ) ] . obo:CL_0009022 obo:IAO_0000115 "A stromal cell found in the lamina propria of the small intestine." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of small intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ) ] . obo:CL_0009024 obo:IAO_0000115 "A mesothelial cell that is part of the small intestine." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "mesothelial cell of small intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_0009025 obo:IAO_0000115 "A mesothelial cell that is part of the colon." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "mesothelial cell of large intestine" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "mesothelial cell of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009037 obo:IAO_0000115 "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "mantle zone B cell" ; oboInOwl:hasExactSynonym "mantle zone B cell of lymph node" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymph node mantle zone B cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010420 ] ) ] . obo:CL_0009038 obo:IAO_0000115 "A macrophage that is located in the colon." ; dcterms:contributor ; oboInOwl:hasExactSynonym "macrophage of colon" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "colon macrophage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009039 obo:IAO_0000115 "A goblet cell that is located in the colon." ; dcterms:contributor ; oboInOwl:hasExactSynonym "goblet cell of colon" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "colon goblet cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009040 obo:IAO_0000115 "A stromal cell found in the lamina propria of the colon." ; dcterms:contributor ; oboInOwl:hasExactSynonym "stromal cell of colon lamina propria" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of lamina propria of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007177 ] ) ] . obo:CL_0009042 obo:IAO_0000115 "An enteroendocrine cell that is located in the colon." ; dcterms:contributor ; oboInOwl:hasExactSynonym "colon enteroendocrine cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0009044 obo:IAO_0000115 "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "gastrointestinal tract small intestine (lamina propria) leukocyte", "small intestine lamina propria leukocyte", "small intestine lamina propria leukocyte (LPL)" ; oboInOwl:hasExactSynonym "gastrointestinal tract (lamina propria) lymphocyte of small intestine", "lamina propria lymphocyte of small intestine", "small intestine lamina propria lymphocyte" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "lymphocyte of small intestine lamina propria" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001238 ] ) ] . obo:CL_0009045 obo:IAO_0000115 "A B cell found in the lymph node medullary sinus." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "B cell of medullary sinus of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009046 obo:IAO_0000115 "A T cell found in the lymph node medullary sinus." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "T cell of medullary sinus of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009047 obo:IAO_0000115 "A macrophage found in the medullary sinus of the lymph node." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "medullary sinus macrophage" ; oboInOwl:hasExactSynonym "lymph node medullary sinus macrophage" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "macrophage of medullary sinus of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009744 ] ) ] . obo:CL_0009048 obo:IAO_0000115 "A macrophage that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "macrophage of anorectum" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "anorectum macrophage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009050 obo:IAO_0000115 "A B cell that is located in the anorectum." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "B cell of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009051 obo:IAO_0000115 "A T cell that is located in the anorectum." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "T cell of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000084 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009052 obo:IAO_0000115 "A smooth muscle cell that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "anorectum smooth muscle cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "smooth muscle cell of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009053 obo:IAO_0000115 "A stromal cell found in the lamina propria of the anorectum." ; dcterms:contributor ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "stromal cell of anorectum lamina propria" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011189 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009057 obo:IAO_0000115 "A goblet cell that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "goblet cell of anorectum" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "anorectum goblet cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009063 obo:IAO_0000115 "An enteroendocrine cell that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "anorectum enteroendocrine cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "enteroendocrine cell of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:CL_0009066 obo:IAO_0000115 "A stratified squamous epithelial cell that is part of the anal canal." ; dcterms:contributor ; oboInOwl:hasExactSynonym "anal canal stratified squamous epithelial cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ; rdfs:label "stratified squamous epithelial cell of anal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000240 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:CL_0009084 obo:IAO_0000115 "An epithelial cell that is part of an endometrial gland." ; dcterms:contributor ; dcterms:date "2021-11-30T16:13:30Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010710" ; oboInOwl:hasExactSynonym "endometrial glandular epithelial cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "epithelial cell of endometrial gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002451 ] ) ] . obo:CL_0009086 obo:IAO_0000115 "An endothelial cell that is part of a respiratory system lymphatic vessel." ; dcterms:contributor ; dcterms:date "2021-12-03T14:00:44Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010667" ; oboInOwl:inSubset pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of respiratory system lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003456 ] ) ] . obo:CL_0009089 obo:IAO_0000115 "A pericyte cell that is part of a lung." ; dcterms:contributor ; dcterms:date "2021-12-03T17:13:33Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010669" ; oboInOwl:hasExactSynonym "lung pericyte cell", "pulmonary pericyte" ; oboInOwl:inSubset pato:location_grouping, core:human_reference_atlas ; a owl:Class ; rdfs:label "lung pericyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_0009091 obo:IAO_0000115 "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." ; dcterms:contributor ; dcterms:date "2022-02-18T14:09:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "stem Leydig cell" ; a owl:Class ; rdfs:label "Leydig stem cell" ; rdfs:subClassOf obo:CL_0000034, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005212 ] . obo:CL_0009092 obo:IAO_0000115 "An endothelial cell that is part of a placenta." ; dcterms:contributor ; dcterms:date "2021-12-13T13:53:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010708" ; oboInOwl:hasExactSynonym "placental endothelial cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of placenta" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0009093 obo:IAO_0000115 "A smooth muscle cell that is part of a placenta." ; dcterms:contributor ; dcterms:date "2021-12-13T13:56:42Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010709" ; oboInOwl:hasExactSynonym "placental smooth muscle cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "smooth muscle cell of placenta" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_0009094 obo:IAO_0000115 "An endothelial cell that is part of a hepatic portal vein." ; dcterms:contributor ; dcterms:date "2021-12-13T14:01:05Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "portal endothelial cell" ; oboInOwl:hasDbXref "EFO:0010704" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of hepatic portal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001639 ] ) ] . obo:CL_0009095 obo:IAO_0000115 "An endothelial cell that is part of a uterus." ; dcterms:contributor ; dcterms:date "2021-12-13T14:39:25Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010711" ; oboInOwl:hasExactSynonym "uterine endothelial cell" ; oboInOwl:inSubset pato:location_grouping ; a owl:Class ; rdfs:label "endothelial cell of uterus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:CL_0009097 obo:IAO_0000115 "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." ; dcterms:contributor ; dcterms:date "2022-02-21T15:39:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "embryonic skeletal muscle fiber" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0008002 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000068 ] ) ] . obo:CL_0009100 obo:IAO_0000115 "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." ; dcterms:contributor ; dcterms:date "2022-03-17T12:00:44Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "portal fibroblast" ; a owl:Class ; rdfs:label "hepatic portal fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001279 ] ) ] . obo:CL_0009115 obo:IAO_0000115 "An endothelial cell located in a lymph node lymphatic vessel." ; dcterms:contributor ; a owl:Class ; rdfs:label "lymph node lymphatic vessel endothelial cell" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0010001 obo:IAO_0000115 "A stromal cell that is part_of a bone marrow." ; dcterms:contributor ; oboInOwl:hasExactSynonym "bone marrow stromal cell" ; a owl:Class ; rdfs:label "stromal cell of bone marrow" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0010002 obo:IAO_0000115 "An epithelial cell that is part_of a umbilical artery." ; dcterms:contributor ; oboInOwl:hasExactSynonym "umbilical artery epithelial cell" ; a owl:Class ; rdfs:label "epithelial cell of umbilical artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:CL_0010003 obo:IAO_0000115 "An epithelial cell that is part_of a alveolus of lung." ; dcterms:contributor ; oboInOwl:hasDbXref "MESH:D056809" ; oboInOwl:hasExactSynonym "alveolus of lung epithelial cell" ; a owl:Class ; rdfs:comment "May be merged with pneumocyte in future" ; rdfs:label "epithelial cell of alveolus of lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:CL_0010004 obo:IAO_0000115 "A mononuclear cell that is part_of a bone marrow." ; dcterms:contributor ; oboInOwl:hasExactSynonym "bone marrow mononuclear cell" ; a owl:Class ; rdfs:label "mononuclear cell of bone marrow" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_0010006 a owl:Class ; rdfs:label "cardiac blood vessel endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010008 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cardiac endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010009 oboInOwl:hasExactSynonym "camera type eye photoreceptor cell" ; a owl:Class ; rdfs:label "camera-type eye photoreceptor cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000210 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:CL_0010011 obo:IAO_0000115 "A GABAergic interneuron whose soma is located in the cerebral cortex." ; a owl:Class ; rdfs:label "cerebral cortex GABAergic interneuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011005 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0010012 obo:IAO_0000115 "A CNS neuron of the cerebral cortex." ; dcterms:contributor ; oboInOwl:hasDbXref "BTO:0004102", "FMA:84104" ; oboInOwl:hasExactSynonym "cortical neuron", "neuron of cerebral cortex" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cerebral cortex neuron" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/issues/1359" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_0010017 obo:IAO_0000115 "A zygote in a plant or an animal." ; oboInOwl:hasDbXref "MESH:D015053" ; a owl:Class ; rdfs:label "zygote"@en ; rdfs:seeAlso ; rdfs:subClassOf obo:CL_0000003 . obo:CL_0010020 a owl:Class ; rdfs:label "cardiac glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0010021 oboInOwl:hasDbXref "MESH:D032386" ; a owl:Class ; rdfs:label "cardiac myoblast" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000056 [ a owl:Restriction ; owl:onProperty obo:RO_0002203 ; owl:someValuesFrom obo:CL_0000746 ] ) ] . obo:CL_0010022 obo:IAO_0000115 "A neuron that has its soma in the heart." ; a owl:Class ; rdfs:comment "This term is used in 3 GO terms that were created as part of the heart development focus project." ; rdfs:label "cardiac neuron" ; rdfs:seeAlso "https://github.com/obophenotype/cell-ontology/pull/1488" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:CL_0011001 obo:IAO_0000115 "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." ; a owl:Class ; rdfs:label "spinal cord motor neuron" ; rdfs:subClassOf obo:CL_0000100 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_0011005 obo:IAO_0000115 "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" ; oboInOwl:hasExactSynonym "GABAergic inhibitory interneuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges." ; rdfs:label "GABAergic interneuron" ; rdfs:subClassOf obo:CL_0000498 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_0011007 obo:IAO_0000115 "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." ; oboInOwl:hasExactSynonym "paraxial mesoderm cell", "somitic mesoderm cell" ; oboInOwl:hasNarrowSynonym "presomitic mesoderm cell" ; a owl:Class ; rdfs:label "paraxial cell" ; rdfs:subClassOf obo:CL_0000222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000222 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003059 ] ) ] . obo:CL_0011012 obo:IAO_0000115 "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." ; a owl:Class ; rdfs:label "neural crest cell" ; rdfs:subClassOf obo:CL_0000048, obo:CL_0002321 . obo:CL_0011013 obo:IAO_0000115 "A sperm cell that is cabaple of motion (motility)." ; dcterms:contributor ; a owl:Class ; rdfs:label "motile sperm cell" ; rdfs:subClassOf obo:CL_0000019, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000019 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097722 ] ) ] . obo:CL_0011016 obo:IAO_0000115 "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." ; dcterms:contributor ; a owl:Class ; rdfs:label "flagellated sperm cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0011013 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011013 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030317 ] ) ] . obo:CL_0011019 obo:IAO_0000115 "A mesothelial cell that is part of the epicardium." ; dcterms:contributor ; a owl:Class ; rdfs:label "mesothelial cell of epicardium" ; rdfs:subClassOf obo:CL_0000077 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002348 ] ) ] . obo:CL_0011021 obo:IAO_0000115 "A fibroblast that is part of upper back skin." ; dcterms:contributor ; a owl:Class ; rdfs:label "fibroblast of upper back skin" ; rdfs:subClassOf obo:CL_0011022 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009015 ] ) ] . obo:CL_0011022 obo:IAO_0000115 "A fibroblast that is part of skin of back." ; dcterms:contributor ; a owl:Class ; rdfs:label "fibroblast of skin of back" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001068 ] ) ] . obo:CL_0011024 obo:IAO_0000115 "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." ; dcterms:contributor ; oboInOwl:hasExactSynonym "CD4-negative, CD8-negative, alpha-beta regulatory T cells", "DN Treg", "double-negative alpha-beta regulatory T cell" ; a owl:Class ; rdfs:label "double negative T regulatory cell" ; rdfs:subClassOf obo:CL_0002489 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002489 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050777 ] ) ] . obo:CL_0011025 dcterms:contributor ; oboInOwl:hasExactSynonym "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential.", "Tex cell" ; a owl:Class ; rdfs:label "exhausted T cell" ; rdfs:subClassOf obo:CL_0000911 . obo:CL_0011026 obo:IAO_0000115 "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." ; dcterms:contributor ; a owl:Class ; rdfs:label "progenitor cell" ; rdfs:subClassOf obo:CL_0011115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011115 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000034 ] ) ] . obo:CL_0011027 obo:IAO_0000115 "Any fibroblast that is part of skeletal muscle tissue." ; dcterms:contributor ; oboInOwl:hasExactSynonym "skeleton muscle fibroblast" ; a owl:Class ; rdfs:label "skeletal muscle fibroblast" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:CL_0011030 obo:IAO_0000115 "Any microvascular endothelial cell that is part of the dermis." ; dcterms:contributor ; oboInOwl:hasExactSynonym "DMEC cell", "dermal microvascular endothelium cell" ; a owl:Class ; rdfs:label "dermal microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_0011101 obo:IAO_0000115 "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." ; a owl:Class ; rdfs:label "chorionic trophoblast cell" ; rdfs:subClassOf obo:CL_0000351 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ) ] . obo:CL_0011108 obo:IAO_0000115 "Epithelial cell that is part of the colon epithelium." ; oboInOwl:hasExactSynonym "colonic epithelial cell" ; a owl:Class ; rdfs:label "colon epithelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_0011113 obo:IAO_0000115 "Neuron found in the spiral ganglion." ; a owl:Class ; rdfs:label "spiral ganglion neuron" ; rdfs:subClassOf obo:CL_0000540 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000395 ] ) ] . obo:CL_0011115 obo:IAO_0000115 "A cell that, by division or terminal differentiation, can give rise to other cell types." ; a owl:Class ; rdfs:comment "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ; rdfs:label "precursor cell" ; rdfs:subClassOf obo:CL_0000003 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030154 ] ) ] . obo:CL_0012000 obo:IAO_0000115 "An astrocyte of the forebrain." ; dcterms:contributor ; oboInOwl:hasExactSynonym "forebrain astrocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "astrocyte of the forebrain" ; rdfs:subClassOf obo:CL_0000127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_0012001 obo:IAO_0000115 "A CNS neuron of the forebrain." ; dcterms:contributor ; oboInOwl:hasExactSynonym "forebrain neuron" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "neuron of the forebrain" ; rdfs:subClassOf obo:CL_0000117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_0013000 a owl:Class ; rdfs:label "forebrain radial glial cell"@en ; rdfs:subClassOf obo:CL_0000681 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_0017002 obo:IAO_0000115 "A neuroendocrine cell that is part of the prostate epithelium." ; oboInOwl:created_by ; oboInOwl:hasExactSynonym "neuroendocrine cell of prostate epithelium", "neuroendocrine cell of the prostate" ; a owl:Class ; rdfs:label "prostate neuroendocrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000428 ] ) ] . obo:CL_0017500 obo:IAO_0000115 "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." ; dcterms:contributor ; oboInOwl:creation_date "2010-05-25T01:36:34Z" ; a owl:Class ; rdfs:label "neutrophillic cytoplasm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070046 ] ) ] . obo:CL_0017502 obo:IAO_0000115 "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-22T04:23:25Z" ; oboInOwl:hasNarrowSynonym "eosinophilic" ; a owl:Class ; rdfs:label "acidophilic cytoplasm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002418 ] ) ] . obo:CL_0017503 obo:IAO_0000115 "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-22T04:24:54Z" ; a owl:Class ; rdfs:label "basophilic cytoplasm" ; rdfs:subClassOf obo:GO_0005737 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002094 ] ) ] . obo:CL_0017504 obo:IAO_0000115 "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-28T04:25:23Z" ; a owl:Class ; rdfs:label "polychromatophilic cytoplasm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0070047 ] ) ] . obo:CL_0017505 obo:IAO_0000115 "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-23T10:53:24Z" ; a owl:Class ; rdfs:label "increased nucleus size" ; rdfs:subClassOf obo:GO_0005634 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005634 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000586 ] ) ] . obo:CL_0019001 obo:IAO_0000115 "Any serous secreting cell that is part of the tracheobronchial epithelium." ; dcterms:contributor ; dcterms:date "2020-05-07T16:03:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "serous cell of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "tracheobronchial serous cell"@en ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019002 obo:IAO_0000115 "Any chondrocyte that is part of the tracheobronchial tree." ; dcterms:contributor ; dcterms:date "2020-05-07T17:29:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "chondrocyte of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA, core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheobronchial chondrocyte"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019003 obo:IAO_0000115 "Any goblet cell that is part of the tracheobronchial epithelium." ; dcterms:contributor ; dcterms:date "2020-05-07T18:14:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "goblet cell of tracheobronchial tree" ; oboInOwl:inSubset cl:added_for_HCA ; a owl:Class ; rdfs:label "tracheobronchial goblet cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019017 obo:IAO_0000115 "A smooth muscle cell that is part of any lymphatic vessel." ; dcterms:contributor ; dcterms:date "2020-07-21T12:29:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "smooth muscle cell of lymphatic vessel" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymphatic vessel smooth muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:CL_0019018 obo:IAO_0000115 "A smooth muscle cell that is part of any blood vessel." ; dcterms:contributor ; dcterms:date "2020-07-21T12:42:48Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "smooth muscle cell of blood vessel" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "blood vessel smooth muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:CL_0019019 obo:IAO_0000115 "A smooth muscle cell that is part of the tracheobronchial tree." ; dcterms:contributor ; dcterms:date "2020-07-21T12:50:22Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "smooth muscle cell of tracheobronchial tree" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheobronchial smooth muscle cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:CL_0019020 obo:IAO_0000115 "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." ; dcterms:contributor ; dcterms:date "2020-09-03T12:24:24Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "large bile duct cholangiocyte" ; a owl:Class ; rdfs:label "extrahepatic cholangiocyte"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000488 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004822 ] ) ] . obo:CL_0019021 obo:IAO_0000115 "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." ; dcterms:contributor ; dcterms:date "2020-09-09T13:56:47Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010705" ; oboInOwl:hasExactSynonym "periportal LSEC", "periportal hepatic sinusoidal endothelial cell" ; a owl:Class ; rdfs:label "endothelial cell of periportal hepatic sinusoid"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000398 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001279 ] ) ] . obo:CL_0019022 obo:IAO_0000115 "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." ; dcterms:contributor ; dcterms:date "2020-09-10T12:38:29Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010706" ; oboInOwl:hasExactSynonym "central venous hepatic sinusoidal endothelial cell", "pericentral LSEC" ; a owl:Class ; rdfs:label "endothelial cell of pericentral hepatic sinusoid"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000398 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006841 ] ) ] . obo:CL_0019031 obo:IAO_0000115 "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." ; dcterms:contributor ; dcterms:date "2020-10-14T14:59:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "intestinal goblet cell" ; a owl:Class ; rdfs:label "intestine goblet cell"@en ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277 ] ) ] . obo:CL_1000042 a owl:Class ; rdfs:label "forebrain neuroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000031 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:CL_1000073 a owl:Class ; rdfs:label "spinal cord radial glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000681 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_1000090 a owl:Class ; rdfs:label "pronephric nephron tubule epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005310 ] ) ] . obo:CL_1000123 a owl:Class ; rdfs:label "metanephric nephron tubule epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005146 ] ) ] . obo:CL_1000143 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung goblet cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000147 obo:IAO_0000115 "A cell that is part of a cardiac valve." ; oboInOwl:hasExactSynonym "heart valve cell" ; a owl:Class ; rdfs:label "cardiac valve cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_1000222 a owl:Class ; rdfs:label "stomach neuroendocrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_1000223 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung neuroendocrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000271 oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung ciliated cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_4030034 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000064 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000272 a owl:Class ; rdfs:label "lung secretory cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1000274 oboInOwl:hasExactSynonym "trophectoderm cell" ; a owl:Class ; rdfs:label "trophectodermal cell" ; rdfs:subClassOf obo:CL_0000349 . obo:CL_1000275 obo:IAO_0000115 "A smooth muscle cell that is part of the small intestine." ; oboInOwl:hasDbXref "FMA:15050" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of small intestine" ; a owl:Class ; rdfs:label "smooth muscle cell of small intestine" ; rdfs:subClassOf obo:CL_0002504 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_1000276 obo:IAO_0000115 "A smooth muscle cell that is part of the duodenum." ; oboInOwl:hasDbXref "FMA:15058" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of duodenum" ; a owl:Class ; rdfs:label "smooth muscle fiber of duodenum" ; rdfs:subClassOf obo:CL_1000275 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1000277 obo:IAO_0000115 "A smooth muscle cell that is part of the jejunum." ; oboInOwl:hasDbXref "FMA:15062" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of jejunum" ; a owl:Class ; rdfs:label "smooth muscle fiber of jejunum" ; rdfs:subClassOf obo:CL_1000275 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:CL_1000278 obo:IAO_0000115 "A smooth muscle cell that is part of the ileum." ; oboInOwl:hasDbXref "FMA:15066" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of ileum" ; a owl:Class ; rdfs:label "smooth muscle fiber of ileum" ; rdfs:subClassOf obo:CL_1000275 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:CL_1000279 obo:IAO_0000115 "A smooth muscle cell that is part of the large intestine." ; oboInOwl:hasDbXref "FMA:15653" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of large intestine" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of large intestine" ; rdfs:subClassOf obo:CL_0002504 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_1000280 obo:IAO_0000115 "A smooth muscle cell that is part of the colon." ; oboInOwl:hasDbXref "FMA:15663" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of colon" ; a owl:Class ; rdfs:label "smooth muscle cell of colon" ; rdfs:subClassOf obo:CL_0002504 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1000284 obo:IAO_0000115 "A smooth muscle cell that is part of the descending colon." ; oboInOwl:hasDbXref "FMA:17520" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of descending colon" ; a owl:Class ; rdfs:label "smooth muscle fiber of descending colon" ; rdfs:subClassOf obo:CL_1000280 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001158 ] ) ] . obo:CL_1000285 obo:IAO_0000115 "A smooth muscle cell that is part of the sigmoid colon." ; oboInOwl:hasDbXref "FMA:17521" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of sigmoid colon" ; a owl:Class ; rdfs:label "smooth muscle cell of sigmoid colon" ; rdfs:subClassOf obo:CL_1000280 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:CL_1000286 obo:IAO_0000115 "A smooth muscle cell that is part of the rectum." ; oboInOwl:hasDbXref "FMA:17522" ; oboInOwl:hasExactSynonym "non-striated muscle fiber of rectum", "smooth muscle fiber of rectum" ; a owl:Class ; rdfs:label "smooth muscle cell of rectum" ; rdfs:subClassOf obo:CL_0002504 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:CL_1000296 obo:IAO_0000115 "An epithelial cell that is part of the urethra." ; oboInOwl:hasDbXref "FMA:256165" ; a owl:Class ; rdfs:label "epithelial cell of urethra" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:CL_1000298 obo:IAO_0000115 "A mesothelial cell that is part of the dura mater." ; oboInOwl:hasDbXref "FMA:256516" ; oboInOwl:hasExactSynonym "squamous mesothelial cell of dura mater" ; a owl:Class ; rdfs:label "mesothelial cell of dura mater" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002363 ] ) ] . obo:CL_1000303 obo:IAO_0000115 "A fibroblast that is part of the areolar connective tissue." ; oboInOwl:hasDbXref "FMA:261279" ; a owl:Class ; rdfs:label "fibroblast of areolar connective tissue" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006815 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006815 ] ) ] . obo:CL_1000306 obo:IAO_0000115 "A fibroblast that is part of the tunica adventitia of artery." ; oboInOwl:hasDbXref "FMA:261285" ; a owl:Class ; rdfs:label "fibroblast of tunica adventitia of artery" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005734 ] ) ] . obo:CL_1000307 obo:IAO_0000115 "A fibroblast that is part of the dense regular elastic tissue." ; oboInOwl:hasDbXref "FMA:261287" ; a owl:Class ; rdfs:label "fibroblast of dense regular elastic tissue" ; rdfs:subClassOf obo:CL_0000057, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002521 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007846 ] ) ] . obo:CL_1000309 obo:IAO_0000115 "A fat cell that is part of the epicardial fat." ; oboInOwl:hasDbXref "FMA:261293" ; oboInOwl:hasExactSynonym "adipocyte of epicardial fat", "epicardial fat cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epicardial adipocyte" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002348 ] . obo:CL_1000310 obo:IAO_0000115 "A fat cell that is part of the epicardial fat of right ventricle." ; oboInOwl:hasDbXref "FMA:261297" ; oboInOwl:hasExactSynonym "epicardial adipocyte of right ventricle", "epicardial fat cell of right ventricle" ; a owl:Class ; rdfs:label "adipocyte of epicardial fat of right ventricle" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:CL_1000311 obo:IAO_0000115 "A fat cell that is part of the epicardial fat of left ventricle." ; oboInOwl:hasDbXref "FMA:261300" ; oboInOwl:hasExactSynonym "epicardial adipocyte of left ventricle", "epicardial fat cell of left ventricle" ; a owl:Class ; rdfs:label "adipocyte of epicardial fat of left ventricle" ; rdfs:subClassOf obo:CL_0000136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:CL_1000312 obo:IAO_0000115 "A goblet cell that is part of the epithelium of bronchus." ; oboInOwl:hasDbXref "FMA:263032" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of bronchus" ; a owl:Class ; rdfs:label "bronchial goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_1000313 obo:IAO_0000115 "A goblet cell that is part of the epithelium of stomach." ; oboInOwl:hasDbXref "FMA:263035" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of stomach" ; a owl:Class ; rdfs:label "gastric goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:CL_1000317 obo:IAO_0000115 "A goblet cell that is part of the epithelium of intestinal villus." ; oboInOwl:hasDbXref "FMA:263046" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of intestinal villus" ; a owl:Class ; rdfs:label "intestinal villus goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013636 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:CL_1000320 obo:IAO_0000115 "A goblet cell that is part of the epithelium of large intestine." ; oboInOwl:hasDbXref "FMA:263054" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of large intestine" ; a owl:Class ; rdfs:label "large intestine goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:CL_1000322 obo:IAO_0000115 "A goblet cell that is part of the epithelium of pancreatic duct." ; oboInOwl:hasDbXref "FMA:263058" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of pancreatic duct" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic goblet cell" ; rdfs:subClassOf obo:CL_0000069, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:CL_1000323 obo:IAO_0000115 "A goblet cell that is part of the epithelium of pyloric gland." ; oboInOwl:hasDbXref "FMA:263061" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of pyloric gland" ; a owl:Class ; rdfs:label "pyloric gastric gland goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008861 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008861 ] ) ] . obo:CL_1000324 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of duodenum." ; oboInOwl:hasDbXref "FMA:263063" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of duodenum" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodenal goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1000325 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of jejunum." ; oboInOwl:hasDbXref "FMA:263065" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of jejunum" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:CL_1000326 obo:IAO_0000115 "A goblet cell that is part of the epithelium proper of ileum." ; oboInOwl:hasDbXref "FMA:263067" ; oboInOwl:hasExactSynonym "goblet cell of epithelium proper of ileum" ; a owl:Class ; rdfs:label "ileal goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:CL_1000329 obo:IAO_0000115 "A goblet cell that is part of the epithelium of trachea." ; oboInOwl:hasDbXref "FMA:263075" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of trachea" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tracheal goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:CL_1000330 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of trachea." ; oboInOwl:hasDbXref "FMA:263078" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "serous cell of epithelium of trachea" ; rdfs:subClassOf obo:CL_0000313, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 ] ) ] . obo:CL_1000331 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of bronchus." ; oboInOwl:hasDbXref "FMA:263080" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "serous cell of epithelium of bronchus" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002031 ] ) ] . obo:CL_1000332 obo:IAO_0000115 "A serous secreting cell that is part of the epithelium of terminal bronchiole." ; oboInOwl:hasDbXref "FMA:263082" ; a owl:Class ; rdfs:label "serous cell of epithelium of terminal bronchiole" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001958 ] ) ] . obo:CL_1000361 obo:IAO_0000115 "A transitional myocyte that is part of the interatrial septum." ; oboInOwl:hasDbXref "FMA:263152" ; a owl:Class ; rdfs:label "transitional myocyte of interatrial septum" ; rdfs:subClassOf obo:CL_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002085 ] ) ] . obo:CL_1000362 obo:IAO_0000115 "A transitional myocyte that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:263154" ; a owl:Class ; rdfs:label "transitional myocyte of interventricular septum" ; rdfs:subClassOf obo:CL_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000376 obo:IAO_0000115 "A Purkinje myocyte that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:263182" ; a owl:Class ; rdfs:label "Purkinje myocyte of interventricular septum" ; rdfs:subClassOf obo:CL_0002068 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000391 obo:IAO_0000115 "A melanocyte that is part of the eyelid." ; oboInOwl:hasDbXref "FMA:59175" ; oboInOwl:hasExactSynonym "eyelid melanocyte", "sebaceous gland of wolff" ; a owl:Class ; rdfs:label "melanocyte of eyelid" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:CL_1000398 obo:IAO_0000115 "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." ; oboInOwl:hasDbXref "BTO:000125", "FMA:62911" ; oboInOwl:hasExactSynonym "LSEC", "endotheliocyte of hepatic sinusoid", "liver sinusoidal endothelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of hepatic sinusoid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001281 ] ) ] . obo:CL_1000409 obo:IAO_0000115 "A muscle cell that is part of the sinoatrial node." ; oboInOwl:hasDbXref "FMA:67102" ; oboInOwl:hasExactSynonym "SA nodal myocyte", "SA node cardiac muscle cell", "myocyte of sinoatrial node", "sinoatrial node cell", "sinoatrial node myocyte", "sinuatrial node myocyte" ; a owl:Class ; rdfs:label "myocyte of sinoatrial node" ; rdfs:subClassOf obo:CL_0002072 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002351 ] ) ] . obo:CL_1000410 obo:IAO_0000115 "A muscle cell that is part of the atrioventricular node." ; oboInOwl:hasDbXref "FMA:67106" ; oboInOwl:hasExactSynonym "AV nodal myocyte", "AV node cardiac muscle cell", "AV node cell", "atrioventricular node cell", "atrioventricular node myocyte" ; a owl:Class ; rdfs:label "myocyte of atrioventricular node" ; rdfs:subClassOf obo:CL_0002072 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002352 ] ) ] . obo:CL_1000412 obo:IAO_0000115 "An endothelial cell that is part of the arteriole." ; oboInOwl:hasDbXref "FMA:67760", "KUPO:0001097" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of arteriole" ; rdfs:subClassOf obo:CL_0000071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ) ] . obo:CL_1000413 obo:IAO_0000115 "A blood vessel endothelial cell that is part of an arterial endothelium." ; oboInOwl:hasDbXref "BTO:0004758", "FMA:67761", "KUPO:0001095" ; oboInOwl:hasExactSynonym "arterial endothelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of artery" ; rdfs:subClassOf obo:CL_0000071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001917 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:CL_1000414 obo:IAO_0000115 "An endothelial cell that is part of the venule." ; oboInOwl:hasDbXref "FMA:67762" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endothelial cell of venule" ; rdfs:subClassOf obo:CL_0002139 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001979 ] ) ] . obo:CL_1000415 obo:IAO_0000115 "An epithelial cell that is part of the gallbladder." ; oboInOwl:hasDbXref "FMA:67780" ; a owl:Class ; rdfs:label "epithelial cell of gallbladder" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_1000426 obo:IAO_0000115 "A chromaffin cell that is part of the adrenal gland." ; oboInOwl:hasDbXref "FMA:69794" ; oboInOwl:hasExactSynonym "adrenal chromaffin cell" ; a owl:Class ; rdfs:label "chromaffin cell of adrenal gland" ; rdfs:subClassOf obo:CL_0000150, obo:CL_0000166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] . obo:CL_1000427 obo:IAO_0000115 "A chromaffin cell that is part of the adrenal cortex." ; oboInOwl:hasDbXref "FMA:69795" ; oboInOwl:hasExactSynonym "chromaffin cell of adrenal cortex" ; a owl:Class ; rdfs:comment "Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin." ; rdfs:label "adrenal cortex chromaffin cell" ; rdfs:subClassOf obo:CL_0000166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_1000428 obo:IAO_0000115 "A somatic stem cell that is part of the epidermis." ; oboInOwl:hasDbXref "FMA:70541" ; oboInOwl:hasExactSynonym "epidermal stem cell" ; a owl:Class ; rdfs:label "stem cell of epidermis" ; rdfs:subClassOf obo:CL_0000723 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000723 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_1000432 obo:IAO_0000115 "An epithelial cell that is part of the conjunctiva." ; oboInOwl:hasDbXref "FMA:70552" ; oboInOwl:hasExactSynonym "epithelial cell of conjunctiva" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "conjunctival epithelial cell" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:CL_1000434 obo:IAO_0000115 "An epithelial cell that is part of the external acoustic meatus." ; oboInOwl:hasDbXref "FMA:70555" ; a owl:Class ; rdfs:label "epithelial cell of external acoustic meatus" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001352 ] ) ] . obo:CL_1000435 obo:IAO_0000115 "An epithelial cell that is part of the lacrimal duct." ; oboInOwl:hasDbXref "FMA:70559" ; a owl:Class ; rdfs:label "epithelial cell of lacrimal duct" ; rdfs:subClassOf obo:CL_0000072 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ] ) ] . obo:CL_1000436 obo:IAO_0000115 "An epithelial cell that is part of the lacrimal sac." ; oboInOwl:hasDbXref "FMA:70560" ; a owl:Class ; rdfs:label "epithelial cell of lacrimal sac" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001351 ] ) ] . obo:CL_1000437 obo:IAO_0000115 "An epithelial cell that is part of the nasolacrimal duct." ; oboInOwl:hasDbXref "FMA:70561" ; a owl:Class ; rdfs:label "epithelial cell of nasolacrimal duct" ; rdfs:subClassOf obo:CL_0000072 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002392 ] ) ] . obo:CL_1000443 obo:IAO_0000115 "A smooth muscle cell that is part of the ciliary body." ; oboInOwl:hasDbXref "FMA:70610" ; oboInOwl:hasExactSynonym "smooth muscle cell of ciliary body" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:label "ciliary muscle cell" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 ] ) ] . obo:CL_1000444 obo:IAO_0000115 "A mesothelial cell that is part of the anterior chamber of eyeball." ; oboInOwl:hasDbXref "FMA:70615" ; a owl:Class ; rdfs:label "mesothelial cell of anterior chamber of eye" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001766 ] ) ] . obo:CL_1000447 obo:IAO_0000115 "A basal cell that is part of the epithelium of esophagus." ; oboInOwl:hasDbXref "FMA:70731" ; oboInOwl:hasExactSynonym "basal cell of esophageal epithelium" ; a owl:Class ; rdfs:label "epithelial cell of stratum germinativum of esophagus" ; rdfs:subClassOf obo:CL_0000646 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000646 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ) ] . obo:CL_1000448 obo:IAO_0000115 "An epithelial cell that is part of the sweat gland." ; oboInOwl:hasDbXref "FMA:70952" ; a owl:Class ; rdfs:label "epithelial cell of sweat gland" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001820 ] ) ] . obo:CL_1000449 obo:IAO_0000115 "An epithelial cell that is part of the nephron." ; oboInOwl:hasDbXref "FMA:70965" ; a owl:Class ; rdfs:label "epithelial cell of nephron" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 ] ) ] . obo:CL_1000450 obo:IAO_0000115 "An epithelial cell that is part of the glomerular capsule." ; oboInOwl:hasDbXref "FMA:70966", "KUPO:0001034" ; oboInOwl:hasExactSynonym "Bowmans capsule epithelial cell", "epithelial cell of Bowman's capsule" ; a owl:Class ; rdfs:label "epithelial cell of glomerular capsule" ; rdfs:subClassOf obo:CL_0000066, obo:CL_0002371, obo:CL_1000510, obo:CL_1000612 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001230 ] ) ] . obo:CL_1000454 obo:IAO_0000115 "An epithelial cell that is part of the collecting duct of renal tubule." ; oboInOwl:hasDbXref "FMA:70982", "KUPO:0001059" ; oboInOwl:hasExactSynonym "epithelial cell of renal collecting tubule" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_0000072, obo:CL_0002518, obo:CL_1001225 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000072 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1000456 obo:IAO_0000115 "A mesothelial cell that is part of the parietal peritoneum." ; oboInOwl:hasDbXref "FMA:72142" ; a owl:Class ; rdfs:label "mesothelial cell of parietal peritoneum" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001366 ] ) ] . obo:CL_1000457 obo:IAO_0000115 "A mesothelial cell that is part of the visceral peritoneum." ; oboInOwl:hasDbXref "FMA:72143" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesothelial cell of visceral peritoneum" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001178 ] ) ] . obo:CL_1000458 obo:IAO_0000115 "A melanocyte that is part of the skin of body." ; oboInOwl:hasDbXref "CALOHA:TS-2374", "FMA:72144" ; oboInOwl:hasExactSynonym "skin melanocyte" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "melanocyte of skin" ; rdfs:subClassOf obo:CL_0000148, obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] . obo:CL_1000465 obo:IAO_0000115 "A chromaffin cell that is part of the ovary." ; oboInOwl:hasDbXref "FMA:74319" ; a owl:Class ; rdfs:label "chromaffin cell of ovary" ; rdfs:subClassOf obo:CL_0000166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_1000466 obo:IAO_0000115 "A chromaffin cell that is part of the right ovary." ; oboInOwl:hasDbXref "FMA:74320" ; a owl:Class ; rdfs:label "chromaffin cell of right ovary" ; rdfs:subClassOf obo:CL_0000166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002118 ] ) ] . obo:CL_1000467 obo:IAO_0000115 "A chromaffin cell that is part of the left ovary." ; oboInOwl:hasDbXref "FMA:74321" ; a owl:Class ; rdfs:label "chromaffin cell of left ovary" ; rdfs:subClassOf obo:CL_0000166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002119 ] ) ] . obo:CL_1000478 obo:IAO_0000115 "A transitional myocyte that is part of the sinoatrial node." ; oboInOwl:hasDbXref "FMA:83384" ; oboInOwl:hasExactSynonym "transitinal myocyte of sinuatrial node" ; a owl:Class ; rdfs:label "transitional myocyte of sinoatrial node" ; rdfs:subClassOf obo:CL_0002073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002351 ] ) ] . obo:CL_1000479 obo:IAO_0000115 "A Purkinje myocyte that is part of the atrioventricular node." ; oboInOwl:hasDbXref "FMA:83386" ; a owl:Class ; rdfs:label "Purkinje myocyte of atrioventricular node" ; rdfs:subClassOf obo:CL_0002068 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002068 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002352 ] ) ] . obo:CL_1000482 obo:IAO_0000115 "A myocardial endocrine cell that is part of the interventricular septum." ; oboInOwl:hasDbXref "FMA:83390" ; a owl:Class ; rdfs:label "myocardial endocrine cell of interventricular septum" ; rdfs:subClassOf obo:CL_0002074 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:CL_1000487 obo:IAO_0000115 "A smooth muscle cell that is part of the prostate gland." ; oboInOwl:hasDbXref "FMA:84583" ; oboInOwl:hasExactSynonym "smooth muscle fiber of prostate" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle cell of prostate" ; rdfs:subClassOf obo:CL_0000192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_1000488 obo:IAO_0000115 "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." ; oboInOwl:hasDbXref "FMA:86481" ; oboInOwl:hasExactSynonym "epithelial cell of bile duct" ; a owl:Class ; rdfs:label "cholangiocyte" ; rdfs:subClassOf obo:CL_0000069, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0005026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0015106 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032782 ] ) ] ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000069 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015106 ] ) ] . obo:CL_1000490 obo:IAO_0000115 "A mesothelial cell that is part of the peritoneum." ; oboInOwl:hasDbXref "FMA:86736" ; oboInOwl:hasExactSynonym "peritoneal mesothelial cell" ; a owl:Class ; rdfs:label "mesothelial cell of peritoneum" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] . obo:CL_1000491 obo:IAO_0000115 "A mesothelial cell that is part of the pleura." ; oboInOwl:hasDbXref "FMA:86737" ; oboInOwl:hasExactSynonym "pleural mesothelial cell" ; a owl:Class ; rdfs:label "mesothelial cell of pleura" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000977 ] ) ] . obo:CL_1000492 obo:IAO_0000115 "A mesothelial cell that is part of the parietal pleura." ; oboInOwl:hasDbXref "FMA:86738" ; a owl:Class ; rdfs:label "mesothelial cell of parietal pleura" ; rdfs:subClassOf obo:CL_0000077, obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002400 ] ) ] . obo:CL_1000493 obo:IAO_0000115 "A mesothelial cell that is part of the visceral pleura." ; oboInOwl:hasDbXref "FMA:86739" ; a owl:Class ; rdfs:label "mesothelial cell of visceral pleura" ; rdfs:subClassOf obo:CL_0002371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002401 ] ) ] . obo:CL_1000494 obo:IAO_0000115 "An epithelial cell that is part of a nephron tubule." ; oboInOwl:hasDbXref "FMA:86785", "KUPO:0001022" ; oboInOwl:hasExactSynonym "kidney tubule epithelial cell" ; a owl:Class ; rdfs:comment "This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON." ; rdfs:label "nephron tubule epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004810 ] ) ] . obo:CL_1000495 obo:IAO_0000115 "A goblet cell that is part of the small intestine." ; oboInOwl:hasDbXref "FMA:86929" ; oboInOwl:hasExactSynonym "goblet cell of epithelium of small intestine", "goblet cell of small intestine", "small intestinal goblet cell" ; a owl:Class ; rdfs:label "small intestine goblet cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_1000497 oboInOwl:hasDbXref "KUPO:0001010" ; a owl:Class ; rdfs:label "kidney cell" ; rdfs:subClassOf obo:CL_0000548, obo:CL_0002371, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_1000500 oboInOwl:hasDbXref "KUPO:0001013" ; a owl:Class ; rdfs:label "kidney interstitial cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1000504 oboInOwl:hasDbXref "KUPO:0001017" ; a owl:Class ; rdfs:label "kidney medulla cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ) ] . obo:CL_1000505 oboInOwl:hasDbXref "KUPO:0001018" ; a owl:Class ; rdfs:label "kidney pelvis cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ) ] . obo:CL_1000507 oboInOwl:hasDbXref "KUPO:0001020" ; a owl:Class ; rdfs:label "kidney tubule cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ) ] . obo:CL_1000510 oboInOwl:hasDbXref "KUPO:0001023" ; a owl:Class ; rdfs:label "kidney glomerular epithelial cell" ; rdfs:subClassOf obo:CL_0002518, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004188 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002518 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004188 ] ) ] . obo:CL_1000546 oboInOwl:hasDbXref "KUPO:0001060" ; a owl:Class ; rdfs:label "kidney medulla collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005185 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005185 ] ) ] . obo:CL_1000547 obo:IAO_0000115 "An epithelial cell that is part of some inner medullary collecting duct." ; oboInOwl:hasDbXref "KUPO:0001061" ; a owl:Class ; rdfs:label "kidney inner medulla collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ) ] . obo:CL_1000549 oboInOwl:hasDbXref "KUPO:0001063" ; a owl:Class ; rdfs:label "kidney cortex collecting duct epithelial cell" ; rdfs:subClassOf obo:CL_1000497, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] . obo:CL_1000600 oboInOwl:hasDbXref "KUPO:0001115" ; a owl:Class ; rdfs:label "lower urinary tract cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ) ] . obo:CL_1000601 oboInOwl:hasDbXref "KUPO:0001116" ; a owl:Class ; rdfs:label "ureteral cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:CL_1000606 oboInOwl:hasDbXref "KUPO:0001015" ; a owl:Class ; rdfs:label "kidney nerve cell" ; rdfs:subClassOf obo:CL_1000500, obo:CL_2000032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:CL_1000612 oboInOwl:hasDbXref "KUPO:0001021" ; a owl:Class ; rdfs:label "kidney corpuscule cell" ; rdfs:subClassOf obo:CL_0002584, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ] ) ] . obo:CL_1000617 oboInOwl:hasDbXref "KUPO:0001026" ; a owl:Class ; rdfs:label "kidney inner medulla cell" ; rdfs:subClassOf obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ) ] . obo:CL_1000681 oboInOwl:hasDbXref "KUPO:0001091" ; a owl:Class ; rdfs:label "kidney cortex interstitial cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000500, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ) ] . obo:CL_1000682 oboInOwl:hasDbXref "KUPO:0001092" ; a owl:Class ; rdfs:label "kidney medulla interstitial cell" ; rdfs:subClassOf obo:CL_1000500, obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ) ] . obo:CL_1000692 oboInOwl:hasDbXref "KUPO:0001102" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney interstitial fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1000702 oboInOwl:hasDbXref "KUPO:0001113" ; a owl:Class ; rdfs:label "kidney pelvis smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000505, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004227 ] ) ] . obo:CL_1000708 oboInOwl:hasDbXref "KUPO:0001119" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ureter adventitial cell" ; rdfs:subClassOf obo:CL_0000115, obo:CL_0002503, obo:CL_1000601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000601 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001252 ] ) ] . obo:CL_1000714 oboInOwl:hasDbXref "KUPO:0001130" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney cortex collecting duct principal cell" ; rdfs:subClassOf obo:CL_0005009, obo:CL_1000549, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004203 ] ) ] . obo:CL_1000718 oboInOwl:hasDbXref "KUPO:0001134" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney inner medulla collecting duct principal cell" ; rdfs:subClassOf obo:CL_0005009, obo:CL_1000547, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004205 ] ) ] . obo:CL_1000746 oboInOwl:hasDbXref "KUPO:0001036" ; a owl:Class ; rdfs:label "glomerular cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000612, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000612 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:CL_1000803 oboInOwl:hasDbXref "KUPO:0001093" ; a owl:Class ; rdfs:label "kidney inner medulla interstitial cell" ; rdfs:subClassOf obo:CL_1000617, obo:CL_1000682, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000682 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005214 ] ) ] . obo:CL_1000854 oboInOwl:hasDbXref "KUPO:0001014" ; a owl:Class ; rdfs:label "kidney blood vessel cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000504, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003517 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000504 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003517 ] ) ] . obo:CL_1000891 oboInOwl:hasDbXref "KUPO:0001029" ; a owl:Class ; rdfs:label "kidney arterial blood vessel cell" ; rdfs:subClassOf obo:CL_1000854, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003644 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000854 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003644 ] ) ] . obo:CL_1000892 oboInOwl:hasDbXref "KUPO:0001030" ; a owl:Class ; rdfs:label "kidney capillary endothelial cell" ; rdfs:subClassOf obo:CL_0000071, obo:CL_1000854 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000854 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003527 ] ) ] . obo:CL_1000893 oboInOwl:hasDbXref "KUPO:0001031" ; a owl:Class ; rdfs:label "kidney venous blood vessel cell" ; rdfs:subClassOf obo:CL_1000854, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001140 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000854 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001140 ] ) ] . obo:CL_1000979 oboInOwl:hasDbXref "KUPO:0001118" ; a owl:Class ; rdfs:label "ureter smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006855 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006855 ] ) ] . obo:CL_1001005 oboInOwl:hasDbXref "KUPO:0001037" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "glomerular capillary endothelial cell" ; rdfs:subClassOf obo:CL_1000746, obo:CL_1000892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004294 ] ) ] . obo:CL_1001006 oboInOwl:hasDbXref "KUPO:0001038" ; a owl:Class ; rdfs:label "kidney afferent arteriole cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] . obo:CL_1001045 oboInOwl:hasDbXref "KUPO:0001077" ; a owl:Class ; rdfs:label "kidney cortex artery cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000891, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005268 ] ) ] . obo:CL_1001052 oboInOwl:hasDbXref "KUPO:0001084" ; a owl:Class ; rdfs:label "kidney cortex vein cell" ; rdfs:subClassOf obo:CL_0002584, obo:CL_1000893, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005269 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005269 ] ) ] . obo:CL_1001064 oboInOwl:hasDbXref "KUPO:0001096" ; a owl:Class ; rdfs:comment "Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure." ; rdfs:label "kidney artery smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000891 . obo:CL_1001066 oboInOwl:hasDbXref "KUPO:0001098" ; a owl:Class ; rdfs:comment "Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure." ; rdfs:label "kidney arteriole smooth muscle cell" ; rdfs:subClassOf obo:CL_0000192, obo:CL_1000891 . obo:CL_1001096 oboInOwl:hasDbXref "KUPO:0001039" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney afferent arteriole endothelial cell" ; rdfs:subClassOf obo:CL_0000071, obo:CL_1000412, obo:CL_1001006 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] . obo:CL_1001097 oboInOwl:hasDbXref "KUPO:0001040" ; a owl:Class ; rdfs:label "kidney afferent arteriole smooth muscle cell" ; rdfs:subClassOf obo:CL_0000359, obo:CL_1001006, obo:CL_1001066 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004639 ] ) ] . obo:CL_1001135 oboInOwl:hasDbXref "KUPO:0001078" ; a owl:Class ; rdfs:label "arcuate artery cell" ; rdfs:subClassOf obo:CL_1001045, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001138 oboInOwl:hasDbXref "KUPO:0001081" ; a owl:Class ; rdfs:label "interlobular artery cell" ; rdfs:subClassOf obo:CL_1001045, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001213 oboInOwl:hasDbXref "KUPO:0001079" ; a owl:Class ; rdfs:label "arcuate artery endothelial cell" ; rdfs:subClassOf obo:CL_0000071, obo:CL_1000413, obo:CL_1001135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001214 oboInOwl:hasDbXref "KUPO:0001080" ; a owl:Class ; rdfs:label "arcuate artery smooth muscle cell" ; rdfs:subClassOf obo:CL_0000359, obo:CL_1001064, obo:CL_1001135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001552 ] ) ] . obo:CL_1001216 oboInOwl:hasDbXref "KUPO:0001082" ; a owl:Class ; rdfs:label "interlobulary artery endothelial cell" ; rdfs:subClassOf obo:CL_0000071, obo:CL_1000413, obo:CL_1001138 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001217 oboInOwl:hasDbXref "KUPO:0001083" ; a owl:Class ; rdfs:label "interlobulary artery smooth muscle cell" ; rdfs:subClassOf obo:CL_0000359, obo:CL_1001064, obo:CL_1001138 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004723 ] ) ] . obo:CL_1001225 oboInOwl:hasDbXref "KUPO:0001012", "Wikipedia:Kidney_collecting_duct_cell" ; a owl:Class ; rdfs:label "kidney collecting duct cell" ; rdfs:subClassOf obo:CL_1000497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1001318 obo:IAO_0000115 "A pericyte cell located in the kidney interstitium." ; oboInOwl:hasDbXref "KUPO:0001104" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "renal interstitial pericyte" ; rdfs:subClassOf obo:CL_0000669 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ] ) ] . obo:CL_1001319 oboInOwl:hasDbXref "KUPO:0001120" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bladder cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_1001320 oboInOwl:hasDbXref "KUPO:0001123" ; a owl:Class ; rdfs:label "urethra cell" ; rdfs:subClassOf obo:CL_0000548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:CL_1001431 oboInOwl:hasDbXref "KUPO:0001128" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "kidney collecting duct principal cell" ; rdfs:subClassOf obo:CL_0005009, obo:CL_1000454, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0005009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:CL_1001433 obo:IAO_0000115 "An epithelial cell of the exocrine pancreas." ; oboInOwl:hasDbXref "FMA:70986" ; oboInOwl:hasExactSynonym "exocrine pancreas cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "epithelial cell of exocrine pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:CL_1001434 obo:IAO_0000115 "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" ; a owl:Class ; rdfs:label "olfactory bulb interneuron" ; rdfs:subClassOf obo:CL_0000101, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002264 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] . obo:CL_1001516 obo:IAO_0000115 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." ; a owl:Class ; rdfs:label "intestinal enteroendocrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ] ) ] . obo:CL_1001567 oboInOwl:hasRelatedSynonym "endothelial cell of lung", "pulmonary vessel endothelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung endothelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000102 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1001568 oboInOwl:hasDbXref "BTO:0001141" ; oboInOwl:hasRelatedSynonym "PAEC cell" ; a owl:Class ; rdfs:label "pulmonary artery endothelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:CL_1001569 obo:IAO_0000115 "An interneuron with a soma found in the hippocampus." ; oboInOwl:hasDbXref "FMA:84777" ; a owl:Class ; rdfs:label "hippocampal interneuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_1001572 obo:IAO_0000115 "A vascular endothelial cell found in colon blood vessels." ; oboInOwl:hasDbXref "CALOHA:TS-2397" ; oboInOwl:hasRelatedSynonym "colon endothelial cells", "colonic endothelial cell" ; a owl:Class ; rdfs:label "colon endothelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013695 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1001573 obo:IAO_0000115 "Cell of the nasopharyngeal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-2398" ; oboInOwl:hasRelatedSynonym "nasopharynx respiratory epithelial cells" ; a owl:Class ; rdfs:label "nasopharyngeal epithelial cell" ; rdfs:subClassOf obo:CL_0000066, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001951 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:CL_1001575 obo:IAO_0000115 "Squamous cell of uterine cervix epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1251" ; oboInOwl:hasRelatedSynonym "cervix squamous cell", "cervix squamous epithelial cell", "cervix, uterine squamous epithelial cells", "uterine cervix squamous epithelial cell", "uterine cervix squamous epithelial cells" ; a owl:Class ; rdfs:label "uterine cervix squamous cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_1001576 obo:IAO_0000115 "Squamous cell of oral epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1252" ; oboInOwl:hasRelatedSynonym "oral cavity mucosa squamous cell", "oral cavity mucosa squamous epithelial cell", "oral mucosa squamous epithelial cell", "oral mucosa squamous epithelial cells" ; a owl:Class ; rdfs:label "oral mucosa squamous cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002424 ] ) ] . obo:CL_1001577 obo:IAO_0000115 "Squamous cell of tonsil epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1253" ; oboInOwl:hasRelatedSynonym "tonsil squamous epithelial cell", "tonsil squamous epithelial cells", "tonsillar squamous cell", "tonsillar squamous epithelial cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tonsil squamous cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:CL_1001578 obo:IAO_0000115 "Squamous cell of vaginal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1254" ; oboInOwl:hasRelatedSynonym "vagina squamous epithelial cell", "vagina squamous epithelial cells", "vaginal squamous cell", "vaginal squamous epithelial cell" ; a owl:Class ; rdfs:label "vagina squamous cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001344 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:CL_1001579 obo:IAO_0000115 "Glial cell of cerebral cortex." ; oboInOwl:hasDbXref "CALOHA:TS-1256" ; oboInOwl:hasRelatedSynonym "brain cortex glial cell", "cerebral cortex glial cells", "cerebrum cortex glial cell" ; a owl:Class ; rdfs:label "cerebral cortex glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_1001580 obo:IAO_0000115 "A glial cell that is part of the hippocampus." ; oboInOwl:hasDbXref "CALOHA:TS-1257" ; oboInOwl:hasExactSynonym "hippocampus glial cell", "hippocampus neuroglial cell" ; a owl:Class ; rdfs:label "hippocampal glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ] . obo:CL_1001581 obo:IAO_0000115 "Glial cell of lateral ventricle." ; oboInOwl:hasDbXref "CALOHA:TS-1258" ; oboInOwl:hasRelatedSynonym "lateral ventricle glial cells" ; a owl:Class ; rdfs:label "lateral ventricle glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:CL_1001582 obo:IAO_0000115 "Neuron of lateral ventricle." ; oboInOwl:hasDbXref "CALOHA:TS-1261" ; oboInOwl:hasRelatedSynonym "lateral ventricle neural cell", "lateral ventricle neuronal cell", "lateral ventricle neuronal cells" ; a owl:Class ; rdfs:label "lateral ventricle neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:CL_1001586 obo:IAO_0000115 "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." ; oboInOwl:hasDbXref "CALOHA:TS-1272" ; oboInOwl:hasRelatedSynonym "breast glandular cell", "breast glandular cells", "mammary glandular cell" ; a owl:Class ; rdfs:label "mammary gland glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:CL_1001587 obo:IAO_0000115 "Glandular cell of uterine cervix epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1273" ; oboInOwl:hasRelatedSynonym "cervix glandular cell", "cervix, uterine glandular cell", "cervix, uterine glandular cells" ; a owl:Class ; rdfs:label "uterine cervix glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:CL_1001588 obo:IAO_0000115 "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." ; oboInOwl:hasDbXref "CALOHA:TS-1274" ; oboInOwl:hasRelatedSynonym "colon glandular cells" ; a owl:Class ; rdfs:label "colon glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:CL_1001589 obo:IAO_0000115 "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." ; oboInOwl:hasDbXref "CALOHA:TS-1275" ; oboInOwl:hasRelatedSynonym "duodenum glandular cells" ; a owl:Class ; rdfs:label "duodenum glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008346 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:CL_1001590 obo:IAO_0000115 "Glandular cell of epididymal epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1276" ; oboInOwl:hasRelatedSynonym "epididymal glandular cell", "epididymis glandular cells" ; a owl:Class ; rdfs:label "epididymis glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:CL_1001591 obo:IAO_0000115 "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." ; oboInOwl:hasDbXref "CALOHA:TS-1277" ; oboInOwl:hasRelatedSynonym "fallopian tube glandular cell", "fallopian tube glandular cells", "uterine tube glandular cell" ; a owl:Class ; rdfs:label "oviduct glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004804 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:CL_1001592 obo:IAO_0000115 "Glandular cell of gallbladder epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1278" ; oboInOwl:hasExactSynonym "gall bladder glandular cell" ; oboInOwl:hasRelatedSynonym "gall bladder glandular cells", "gallbladder glandular cells" ; a owl:Class ; rdfs:label "gallbladder glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002029 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_1001593 obo:IAO_0000115 "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." ; oboInOwl:hasDbXref "CALOHA:TS-1279" ; oboInOwl:hasRelatedSynonym "parathyroid gland glandular cell", "parathyroid gland glandular cells" ; a owl:Class ; rdfs:label "parathyroid glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011197 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:CL_1001595 obo:IAO_0000115 "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." ; oboInOwl:hasDbXref "CALOHA:TS-1281" ; oboInOwl:hasRelatedSynonym "rectal glandular cell", "rectum glandular cells" ; a owl:Class ; rdfs:label "rectum glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:CL_1001596 obo:IAO_0000115 "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." ; oboInOwl:hasDbXref "CALOHA:TS-1282" ; oboInOwl:hasRelatedSynonym "salivary gland glandular cells" ; a owl:Class ; rdfs:label "salivary gland glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:CL_1001597 obo:IAO_0000115 "Glandular cell of seminal vesicle epithelium." ; oboInOwl:hasDbXref "CALOHA:TS-1283" ; oboInOwl:hasRelatedSynonym "seminal vesicle glandular cells" ; a owl:Class ; rdfs:label "seminal vesicle glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004805 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:CL_1001598 obo:IAO_0000115 "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." ; oboInOwl:hasDbXref "CALOHA:TS-1286", "FMA:86928" ; oboInOwl:hasRelatedSynonym "small bowel glandular cell", "small intestinal glandular cell", "small intestine glandular cells" ; a owl:Class ; rdfs:label "small intestine glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:CL_1001599 obo:IAO_0000115 "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." ; oboInOwl:hasDbXref "BTO:0000028", "CALOHA:TS-1242" ; oboInOwl:hasRelatedSynonym "exocrine pancreas glandular cell", "pancreas exocrine glandular cells" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreas exocrine glandular cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013697 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:CL_1001601 obo:IAO_0000115 "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." ; oboInOwl:hasDbXref "CALOHA:TS-2177" ; oboInOwl:hasRelatedSynonym "adrenal gland glandular cells", "adrenal glandular cell", "suprarenal gland glandular cell" ; a owl:Class ; rdfs:label "adrenal gland glandular cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001235 ] ) ] . obo:CL_1001602 obo:IAO_0000115 "Endothelial cells forming the walls of the capillaries within the cerebral cortex." ; oboInOwl:hasDbXref "CALOHA:TS-2372" ; oboInOwl:hasRelatedSynonym "cerebral cortex endothelial cells", "endothelial cells of cerebral cortex" ; a owl:Class ; rdfs:label "cerebral cortex endothelial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013694 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] . obo:CL_1001603 obo:IAO_0000115 "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." ; oboInOwl:hasDbXref "CALOHA:TS-0576" ; oboInOwl:hasRelatedSynonym "lung macrophages" ; a owl:Class ; rdfs:label "lung macrophage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000235 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_1001606 obo:IAO_0000115 "Keratinocyte from foreskin." ; oboInOwl:hasDbXref "CALOHA:TS-0385" ; a owl:Class ; rdfs:label "foreskin keratinocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:CL_1001607 obo:IAO_0000115 "Chondrocyte forming the hyaline cartilage found in joints." ; oboInOwl:hasDbXref "CALOHA:TS-0056" ; a owl:Class ; rdfs:label "articular chondrocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010996 ] ) ] . obo:CL_1001608 obo:IAO_0000115 "Fibroblast from foreskin." ; oboInOwl:hasDbXref "CALOHA:TS-0384" ; oboInOwl:hasExactSynonym "BJ fibroblast" ; a owl:Class ; rdfs:label "foreskin fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:CL_1001609 obo:IAO_0000115 "Fibroblast from muscle organ." ; oboInOwl:hasDbXref "CALOHA:TS-0643" ; a owl:Class ; rdfs:label "muscle fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] . obo:CL_1001610 obo:IAO_0000115 "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." ; oboInOwl:hasDbXref "CALOHA:TS-2109" ; oboInOwl:hasRelatedSynonym "bone marrow hematopoietic cells", "bone marrow poietic cells" ; a owl:Class ; rdfs:label "bone marrow hematopoietic cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012429 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000988 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:CL_1001611 obo:IAO_0000115 "Neuron of the cerebellum." ; oboInOwl:hasDbXref "CALOHA:TS-2359", "FMA:84665" ; oboInOwl:hasRelatedSynonym "cerebellum neuron" ; a owl:Class ; rdfs:label "cerebellar neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:CL_2000000 obo:IAO_0000115 "Any melanocyte that is part of a epidermis." ; dcterms:contributor ; oboInOwl:creation_date "2014-02-03T23:03:09Z" ; oboInOwl:id "CL:2000000" ; a owl:Class ; rdfs:comment "These cells are found primarily, but not exclusively, in primates including humans" ; rdfs:label "epidermal melanocyte" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:CL_2000001 obo:IAO_0000115 "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." ; dcterms:contributor ; oboInOwl:creation_date "2014-02-11T17:29:04Z" ; oboInOwl:id "CL:2000001" ; a owl:Class ; rdfs:label "peripheral blood mononuclear cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_2000002 obo:IAO_0000115 "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." ; oboInOwl:creation_date "2014-02-20T23:06:41Z" ; oboInOwl:hasDbXref "BTO:0002770", "BTO:0005756", "NCIT:C32429" ; oboInOwl:hasExactSynonym "decidua cell", "decidual stromal cell" ; oboInOwl:id "CL:2000002" ; a owl:Class ; rdfs:label "decidual cell" ; rdfs:subClassOf obo:CL_0000499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002450 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0002255 ] . obo:CL_2000004 obo:IAO_0000115 "Any cell that is part of a pituitary gland." ; dcterms:contributor ; oboInOwl:creation_date "2014-03-26T22:14:56Z" ; oboInOwl:id "CL:2000004" ; a owl:Class ; rdfs:label "pituitary gland cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] . obo:CL_2000005 obo:IAO_0000115 "Any macroglial cell that is part of a brain." ; dcterms:contributor ; oboInOwl:creation_date "2014-03-28T21:35:27Z" ; oboInOwl:id "CL:2000005" ; a owl:Class ; rdfs:label "brain macroglial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000006 obo:IAO_0000115 "Any germinal center B cell that is part of a tonsil." ; dcterms:contributor ; oboInOwl:creation_date "2014-03-28T21:35:33Z" ; oboInOwl:id "CL:2000006" ; a owl:Class ; rdfs:label "tonsil germinal center B cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:CL_2000007 obo:IAO_0000115 "Chondrocyte forming the hyaline cartilage found in the knee joint." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T14:40:11Z" ; oboInOwl:id "CL:2000007" ; a owl:Class ; rdfs:label "articular chondrocyte of knee joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001607 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001485 ] ) ] . obo:CL_2000008 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of a microvascular endothelium." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:07:42Z" ; oboInOwl:id "CL:2000008" ; a owl:Class ; rdfs:label "microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000010 obo:IAO_0000115 "Any blood vessel endothelial cell that is part of a dermis." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:12:06Z" ; oboInOwl:id "CL:2000010" ; a owl:Class ; rdfs:label "dermis blood vessel endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_2000011 obo:IAO_0000115 "Any endothelial cell of lymphatic vessel that is part of a dermis." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:15:08Z" ; oboInOwl:id "CL:2000011" ; a owl:Class ; rdfs:label "dermis lymphatic vessel endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002138 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:CL_2000012 obo:IAO_0000115 "Any skin fibroblast that is part of a pedal digit skin." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:16:44Z" ; oboInOwl:id "CL:2000012" ; a owl:Class ; rdfs:label "fibroblast of pedal digit skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003530 ] ) ] . obo:CL_2000013 obo:IAO_0000115 "Any skin fibroblast that is part of a skin of abdomen." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:18:16Z" ; oboInOwl:id "CL:2000013" ; a owl:Class ; rdfs:label "fibroblast of skin of abdomen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001416 ] ) ] . obo:CL_2000014 obo:IAO_0000115 "Any skin fibroblast that is part of a upper leg skin." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:19:44Z" ; oboInOwl:id "CL:2000014" ; a owl:Class ; rdfs:label "fibroblast of upper leg skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004262 ] ) ] . obo:CL_2000015 obo:IAO_0000115 "Any skin fibroblast that is part of a arm." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T15:29:06Z" ; oboInOwl:id "CL:2000015" ; a owl:Class ; rdfs:label "fibroblast of arm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002620 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:CL_2000016 obo:IAO_0000115 "Any lung endothelial cell that is part of a microvascular endothelium." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T16:00:56Z" ; oboInOwl:id "CL:2000016" ; a owl:Class ; rdfs:label "lung microvascular endothelial cell" ; rdfs:subClassOf obo:CL_2000008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1001567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000017 obo:IAO_0000115 "Any fibroblast that is part of a periodontal ligament." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T16:50:33Z" ; oboInOwl:id "CL:2000017" ; a owl:Class ; rdfs:label "fibroblast of peridontal ligament" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008266 ] ) ] . obo:CL_2000018 obo:IAO_0000115 "Any endothelial cell of artery that is part of a coronary artery." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-04T17:08:47Z" ; oboInOwl:id "CL:2000018" ; a owl:Class ; rdfs:label "endothelial cell of coronary artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000413 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] . obo:CL_2000020 obo:IAO_0000115 "Any native cell that is part of a inner cell mass." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-24T23:16:53Z" ; oboInOwl:id "CL:2000020" ; a owl:Class ; rdfs:label "inner cell mass cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000087 ] ) ] . obo:CL_2000021 obo:IAO_0000115 "Any native cell that is part of a sebaceous gland." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-24T23:17:00Z" ; oboInOwl:id "CL:2000021" ; a owl:Class ; rdfs:label "sebaceous gland cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:CL_2000022 obo:IAO_0000115 "Any native cell that is part of a cardiac septum." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-24T23:17:07Z" ; oboInOwl:id "CL:2000022" ; a owl:Class ; rdfs:label "cardiac septum cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002099 ] ) ] . obo:CL_2000023 obo:IAO_0000115 "Any interneuron that is part of a spinal cord ventral column." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:36Z" ; oboInOwl:id "CL:2000023" ; a owl:Class ; rdfs:label "spinal cord ventral column interneuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000099 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0005375 ] ) ] . obo:CL_2000025 obo:IAO_0000115 "Any oligodendrocyte that is part of a spinal cord." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T00:23:50Z" ; oboInOwl:id "CL:2000025" ; a owl:Class ; rdfs:label "spinal cord oligodendrocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000128 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:CL_2000028 obo:IAO_0000115 "Any glutamatergic neuron that is part of a cerebellum." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T00:24:10Z" ; oboInOwl:id "CL:2000028" ; a owl:Class ; rdfs:label "cerebellum glutamatergic neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000679 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:CL_2000029 obo:IAO_0000115 "Any neuron that is part of a central nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T01:17:43Z" ; oboInOwl:id "CL:2000029" ; a owl:Class ; rdfs:label "central nervous system neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:CL_2000030 obo:IAO_0000115 "Any native cell that is part of a hypothalamus." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T01:17:50Z" ; oboInOwl:id "CL:2000030" ; a owl:Class ; rdfs:label "hypothalamus cell" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] . obo:CL_2000032 obo:IAO_0000115 "A neuron that is part of a peripheral nervous system." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T02:28:17Z" ; oboInOwl:hasDbXref "FMA:84664" ; oboInOwl:hasExactSynonym "PNS neuron", "peripheral neuron" ; oboInOwl:id "CL:2000032" ; a owl:Class ; rdfs:label "peripheral nervous system neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] . obo:CL_2000033 obo:IAO_0000115 "Any basal cell of epidermis that is part of a limb." ; dcterms:contributor ; oboInOwl:creation_date "2014-06-25T02:28:25Z" ; oboInOwl:id "CL:2000033" ; a owl:Class ; rdfs:label "limb basal cell of epidermis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:CL_2000040 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a urinary bladder." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:04:47Z" ; oboInOwl:id "CL:2000040" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bladder microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:CL_2000041 obo:IAO_0000115 "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:09:54Z" ; oboInOwl:id "CL:2000041" ; a owl:Class ; rdfs:label "dermis microvascular lymphatic vessel endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008339 ] ) ] . obo:CL_2000042 obo:IAO_0000115 "Any fibroblast that is part of a embryo." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:12:00Z" ; oboInOwl:id "CL:2000042" ; a owl:Class ; rdfs:label "embryonic fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:CL_2000043 obo:IAO_0000115 "Any pericyte cell that is part of a brain." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:18:22Z" ; oboInOwl:id "CL:2000043" ; a owl:Class ; rdfs:label "brain pericyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000044 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a brain." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:24:53Z" ; oboInOwl:id "CL:2000044" ; a owl:Class ; rdfs:label "brain microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:CL_2000045 obo:IAO_0000115 "Any melanocyte that is part of a prepuce of penis." ; dcterms:contributor ; oboInOwl:creation_date "2014-07-09T00:45:07Z" ; oboInOwl:id "CL:2000045" ; a owl:Class ; rdfs:label "foreskin melanocyte" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:CL_2000046 obo:IAO_0000115 "Any cardiac muscle cell that is part of a cardiac ventricle." ; dcterms:contributor ; oboInOwl:creation_date "2014-08-12T20:50:28Z" ; oboInOwl:id "CL:2000046" ; a owl:Class ; rdfs:label "ventricular cardiac muscle cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:CL_2000047 obo:IAO_0000115 "Any motor neuron that is part of a brainstem." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-02T23:52:53Z" ; oboInOwl:id "CL:2000047" ; a owl:Class ; rdfs:label "brainstem motor neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000100 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002298 ] ) ] . obo:CL_2000051 obo:IAO_0000115 "Any fibroblast that is part of a spleen." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-06T18:58:47Z" ; oboInOwl:id "CL:2000051" ; a owl:Class ; rdfs:label "splenic fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:CL_2000052 obo:IAO_0000115 "Any endothelial cell of artery that is part of a umbilical cord." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-06T19:01:48Z" ; oboInOwl:id "CL:2000052" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=8010" ; rdfs:label "umbilical artery endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000413 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:CL_2000053 obo:IAO_0000115 "Any endothelial cell that is part of a spleen." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-06T19:06:04Z" ; oboInOwl:id "CL:2000053" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5500" ; rdfs:label "splenic endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:CL_2000055 obo:IAO_0000115 "Any dendritic cell that is part of a liver." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-06T19:16:11Z" ; oboInOwl:hasExactSynonym "hepatic dendritic cell" ; oboInOwl:id "CL:2000055" ; a owl:Class ; rdfs:comment "http://www.jleukbio.org/content/66/2/322.abstract" ; rdfs:label "liver dendritic cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000451 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:CL_2000059 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a prostate gland." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:46:27Z" ; oboInOwl:id "CL:2000059" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=4400" ; rdfs:label "prostate gland microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:CL_2000060 obo:IAO_0000115 "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:48:27Z" ; oboInOwl:hasDbXref "BTO:0006119", "BTO:0006208" ; oboInOwl:hasExactSynonym "vCTB", "villous cytotrophoblast" ; oboInOwl:id "CL:2000060" ; a owl:Class ; rdfs:comment "Same as synctial trophoblast?" ; rdfs:label "placental villous trophoblast" ; rdfs:seeAlso "http://www.sciencellonline.com/site/productInformation.php?keyword=7120" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010005 ] ) ] . obo:CL_2000061 obo:IAO_0000115 "Any mesenchymal stem cell that is part of a placenta." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:51:11Z" ; oboInOwl:id "CL:2000061" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7140" ; rdfs:label "placental amniotic mesenchymal stromal cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_2000062 obo:IAO_0000115 "Any capillary endothelial cell that is part of a placenta." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:55:56Z" ; oboInOwl:id "CL:2000062" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.ncbi.nlm.nih.gov/books/NBK53245/" ; rdfs:label "placental villus capillary endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010005 ] ) ] . obo:CL_2000063 obo:IAO_0000115 "Any fibroblast that is part of a female gonad." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:57:42Z" ; oboInOwl:id "CL:2000063" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7330" ; rdfs:label "ovarian fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_2000064 obo:IAO_0000115 "Any epithelial cell that is part of a female gonad." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T17:59:13Z" ; oboInOwl:id "CL:2000064" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7310" ; rdfs:label "ovarian surface epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:CL_2000065 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a female urethra." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:18:01Z" ; oboInOwl:id "CL:2000065" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7300" ; rdfs:label "ovarian microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:CL_2000066 obo:IAO_0000115 "Any fibroblast that is part of a cardiac ventricle." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:35:38Z" ; oboInOwl:id "CL:2000066" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6310" ; rdfs:label "cardiac ventricle fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:CL_2000067 obo:IAO_0000115 "Any fibroblast that is part of a cardiac atrium." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:36:54Z" ; oboInOwl:id "CL:2000067" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6320" ; rdfs:label "cardiac atrium fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:CL_2000068 obo:IAO_0000115 "Any fibroblast that is part of a pericardium." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:38:06Z" ; oboInOwl:id "CL:2000068" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6430" ; rdfs:label "pericardium fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002407 ] ) ] . obo:CL_2000069 obo:IAO_0000115 "Any fibroblast that is part of a gallbladder." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:41:43Z" ; oboInOwl:id "CL:2000069" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5430" ; rdfs:label "gallbladder fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:CL_2000070 obo:IAO_0000115 "Any fibroblast that is part of a optic choroid." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T18:50:43Z" ; oboInOwl:id "CL:2000070" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6620" ; rdfs:label "optic choroid fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] . obo:CL_2000071 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a breast." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T19:55:30Z" ; oboInOwl:id "CL:2000071" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7600" ; rdfs:label "mammary microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_2000072 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a adipose tissue." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-07T22:13:45Z" ; oboInOwl:id "CL:2000072" ; a owl:Class ; rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7200" ; rdfs:label "adipose microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] . obo:CL_2000073 obo:IAO_0000115 "Any migratory neural crest cell that is part of a cardiac neural crest." ; dcterms:contributor ; oboInOwl:creation_date "2014-11-05T01:18:43Z" ; oboInOwl:hasExactSynonym "cardiac neural crest cell" ; oboInOwl:id "CL:2000073" ; a owl:Class ; rdfs:label "migratory cardiac neural crest cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000333 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000095 ] ) ] . obo:CL_2000074 obo:IAO_0000115 "Any leukocyte that is part of a spleen." ; dcterms:contributor ; oboInOwl:creation_date "2014-11-05T01:26:50Z" ; oboInOwl:id "CL:2000074" ; a owl:Class ; rdfs:comment "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology." ; rdfs:label "splenocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:CL_2000076 obo:IAO_0000115 "Any vein endothelial cell that is part of a hindlimb stylopod." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T18:40:47Z" ; oboInOwl:id "CL:2000076" ; a owl:Class ; rdfs:label "hindlimb stylopod vein endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002543 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:CL_2000077 obo:IAO_0000115 "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T18:48:17Z" ; oboInOwl:id "CL:2000077" ; a owl:Class ; rdfs:label "skeletal muscle tissue of pectoralis major striated muscle cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004510 ] ) ] . obo:CL_2000078 obo:IAO_0000115 "Any pericyte cell that is part of a placenta." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T18:51:03Z" ; oboInOwl:id "CL:2000078" ; a owl:Class ; rdfs:label "placental pericyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000669 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:CL_2000079 obo:IAO_0000115 "Any mesenchymal stem cell of the bone marrow that is part of a femur." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T19:07:31Z" ; oboInOwl:id "CL:2000079" ; a owl:Class ; rdfs:label "mesenchymal stem cell of femoral bone marrow" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:CL_2000080 obo:IAO_0000115 "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:34Z" ; oboInOwl:hasExactSynonym "mesenchymal stem cell of abdominal adipose" ; oboInOwl:id "CL:2000080" ; a owl:Class ; rdfs:label "mesenchymal stem cell of abdominal adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:CL_2000081 obo:IAO_0000115 "Any melanocyte of skin that is part of a skin of face." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:40Z" ; oboInOwl:id "CL:2000081" ; a owl:Class ; rdfs:label "melanocyte of skin of face" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000458 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_1000021 ] ) ] . obo:CL_2000082 obo:IAO_0000115 "Any melanocyte of skin that is part of a skin of prepuce of penis." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T19:10:45Z" ; oboInOwl:id "CL:2000082" ; a owl:Class ; rdfs:label "melanocyte of foreskin" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_1000458 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001471 ] ) ] . obo:CL_2000084 obo:IAO_0000115 "Any goblet cell that is part of a conjunctiva." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T19:28:38Z" ; oboInOwl:id "CL:2000084" ; a owl:Class ; rdfs:label "conjunctiva goblet cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000160 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:CL_2000085 obo:IAO_0000115 "Any mononuclear cell that is part of a umbilical cord." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-02T20:14:16Z" ; oboInOwl:id "CL:2000085" ; a owl:Class ; rdfs:label "mononuclear cell of umbilical cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:CL_2000091 obo:IAO_0000115 "Any microvascular endothelial cell that is part of a endometrial blood vessel." ; dcterms:contributor ; oboInOwl:creation_date "2015-03-31T21:02:36Z" ; oboInOwl:id "CL:2000091" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endometrial microvascular endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015172 ] ) ] . obo:CL_2000092 obo:IAO_0000115 "Any keratinocyte that is part of a hair follicle." ; dcterms:contributor ; oboInOwl:creation_date "2015-03-31T21:07:02Z" ; oboInOwl:id "CL:2000092" ; a owl:Class ; rdfs:label "hair follicular keratinocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:CL_2000093 obo:IAO_0000115 "Any fibroblast of lung that is part of a bronchus." ; dcterms:contributor ; oboInOwl:creation_date "2015-03-31T21:16:22Z" ; oboInOwl:id "CL:2000093" ; a owl:Class ; rdfs:label "bronchus fibroblast of lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002553 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:CL_2000095 obo:IAO_0000115 "Any hematopoietic stem cell that is part of a umbilical cord blood." ; dcterms:contributor ; oboInOwl:creation_date "2015-05-26T18:58:34Z" ; oboInOwl:id "CL:2000095" ; a owl:Class ; rdfs:label "cord blood hematopoietic stem cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] . obo:CL_3000000 obo:IAO_0000115 "A ciliated epithelial cell of the esophagus." ; dcterms:contributor ; oboInOwl:creation_date "2019-02-09T16:40:30Z" ; oboInOwl:id "CL:3000000" ; a owl:Class ; rdfs:label "ciliated epithelial cell of esophagus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001976 ] ) ] . obo:CL_3000004 obo:IAO_0000115 "Peripheral sensory neuron." ; dcterms:contributor ; oboInOwl:creation_date "2019-02-25T19:34:33Z" ; oboInOwl:id "CL:3000004" ; a owl:Class ; rdfs:label "peripheral sensory neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_2000032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) ] . obo:CL_4006000 obo:IAO_0000115 "A fibroblast that is part of the breast." ; dcterms:contributor ; oboInOwl:hasExactSynonym "breast fibroblast" ; a owl:Class ; rdfs:label "fibroblast of breast" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:CL_4006001 obo:IAO_0000115 "A fibroblast that is part of the skin of scalp." ; dcterms:contributor ; oboInOwl:hasExactSynonym "skin of scalp fibroblast" ; a owl:Class ; rdfs:label "fibroblast of skin of scalp" ; rdfs:subClassOf obo:CL_0000057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8300000 ] ) ] . obo:CL_4023057 dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "A GABAergic interneuron whose soma is located in the cerebellar cortex." ; rdfs:label "cerebellar inhibitory GABAergic interneuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0011005 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0002129 ] ) ] . obo:CL_4023068 obo:IAO_0000115 "An excitatory neuron that has its soma located in the thalamic complex." ; dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thalamic excitatory neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002100 ; owl:someValuesFrom obo:UBERON_0010225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:CL_4023072 obo:IAO_0000115 "A cell that is part of the brain vasculature." ; dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "brain vascular cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008998 ] ) ] . obo:CL_4023073 obo:IAO_0000115 "A cell that is part of the choroid plexus." ; dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "choroid plexus cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:CL_4023079 obo:IAO_0000115 "A GABAergic inhibitory neuron that is derived from the midbrain." ; dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "midbrain-derived inhibitory neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:CL_4023154 obo:IAO_0000115 "A glial cell that myelinates axonal processes." ; dcterms:contributor ; a owl:Class ; rdfs:label "myelinating glial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043209 ] ) ] . obo:CL_4023168 obo:IAO_0000115 "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." ; dcterms:contributor ; a owl:Class ; rdfs:label "somatosensory neuron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] ) ] . obo:CL_4028001 obo:IAO_0000115 "Any capillary endothelial cell that is part of a lung." ; dcterms:contributor ; oboInOwl:creation_date "2021-11-23T02:31:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "lung capillary endothelial cell" ; a owl:Class ; rdfs:label "pulmonary capillary endothelial cell" ; rdfs:subClassOf obo:CL_2000016 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002144 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:CL_4030000 obo:IAO_0000115 "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." ; dcterms:contributor ; oboInOwl:creation_date "2022-01-20T12:59:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "uveal melanocyte" ; a owl:Class ; rdfs:comment "Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins." ; rdfs:label "choroidal melanocyte" ; rdfs:subClassOf obo:CL_0000548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001768 ] ) ] . obo:CL_4030001 obo:IAO_0000115 "A stromal cell that is part of the thymus." ; dcterms:contributor ; dcterms:date "2022-07-08T11:39:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "thymic stromal cell" ; a owl:Class ; rdfs:label "stromal cell of thymus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:CL_4030002 obo:IAO_0000115 "An alpha-beta memory T cell with the phenotype CD45RA-positive." ; dcterms:contributor ; oboInOwl:creation_date "2022-02-01T13:04:46Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "TEMRA", "effector memory RA T cell" ; oboInOwl:hasExactSynonym "TEMRA cell", "terminally differentiated effector memory CD45RA+ T cells", "terminally differentiated effector memory cells re-expressing CD45RA" ; a owl:Class ; rdfs:label "effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated" ; rdfs:subClassOf obo:CL_0000791 . obo:CL_4030022 obo:IAO_0000115 "A fibroblast that is located in the renal medulla interstitium." ; dcterms:contributor ; dcterms:date "2022-07-05T12:13:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "kidney medullary fibroblast" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis." ; rdfs:label "renal medullary fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 ] ) ] . obo:CL_4030025 obo:IAO_0000115 "A fibroblast that is located in the renal cortical interstitium." ; dcterms:contributor ; dcterms:date "2022-07-05T15:50:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "kidney cortical fibroblast" ; a owl:Class ; rdfs:comment "Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin." ; rdfs:label "renal cortical fibroblast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005270 ] ) ] . obo:CL_4030027 obo:IAO_0000115 "An amacrine cell that uses GABA as a neurotransmitter." ; dcterms:contributor ; dcterms:date "2022-10-17T12:35:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "amacrine cell, GABAergic" ; a owl:Class ; rdfs:label "GABAergic amacrine cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000561 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061534 ] ) ] . obo:CL_4030029 obo:IAO_0000115 "A lymphocyte located in blood." ; dcterms:contributor ; dcterms:date "2022-11-04T14:40:00Z"^^xsd:dateTime ; oboInOwl:inSubset cl:blood_and_immune_upper_slim ; a owl:Class ; rdfs:label "blood lymphocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:CL_4030031 obo:IAO_0000115 "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." ; dcterms:contributor ; dcterms:date "2022-11-30T14:35:08Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "interstitial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005169 ] ) ] . obo:CL_4030032 obo:IAO_0000115 "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." ; dcterms:contributor ; dcterms:date "2022-12-06T14:18:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "VIC", "cardiac valve interstitial cell", "valvular interstitial cell" ; a owl:Class ; rdfs:comment "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis)." ; rdfs:label "valve interstitial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_4030031 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_4030033 obo:IAO_0000115 "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." ; dcterms:contributor ; dcterms:date "2022-12-09T11:58:49Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "VEC", "valvular endothelial cell" ; a owl:Class ; rdfs:comment "At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration." ; rdfs:label "valve endothelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ) ] . obo:CL_4030034 obo:IAO_0000115 "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." ; dcterms:date "2023-01-25T11:06:01Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ciliated cell of the respiratory tract" ; a owl:Class ; rdfs:label "respiratory ciliated cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000064 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004802 ] ) ] . obo:CL_4030035 obo:IAO_0000115 "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." ; dcterms:date "2023-01-10T14:02:02Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "DPSC" ; a owl:Class ; rdfs:label "dental pulp stem cell" ; rdfs:subClassOf obo:CL_0002148 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000034 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001754 ] ) ] . obo:CL_4030040 obo:IAO_0000115 "A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium." ; dcterms:date "2023-02-09T11:25:14Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "ciliated cell of the uterus", "uterine ciliated cell" ; oboInOwl:hasExactSynonym "ciliated cell of the endometrium", "endometrium ciliated epithelial cell" ; a owl:Class ; rdfs:comment "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted." ; rdfs:label "endometrial ciliated epithelial cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000064 obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004811 ] ) ] . obo:CL_4030044 a owl:ObjectProperty ; rdfs:label "has_not_completed" . obo:CL_4030045 obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" ; a owl:ObjectProperty ; rdfs:label "lacks_part" . obo:CL_4030046 obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" ; a owl:ObjectProperty ; rdfs:label "lacks_plasma_membrane_part" . obo:CL_4033000 obo:IAO_0000115 "A(n) endothelial cell that is part of a(n) venule of lymph node." ; dcterms:contributor ; a owl:Class ; rdfs:label "endothelial cell of venule of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410041 ] ) ] . obo:CL_4033001 obo:IAO_0000115 "A(n) endothelial cell that is part of a(n) arteriole of lymph node." ; dcterms:contributor ; a owl:Class ; rdfs:label "endothelial cell of arteriole of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410042 ] ) ] . obo:CL_4033005 obo:IAO_0000115 "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." ; dcterms:contributor ; a owl:Class ; rdfs:label "serous secreting cell of bronchus submucosal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000313 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ) ] . obo:CL_4033008 obo:IAO_0000115 "A(n) vein endothelial cell that is part of a(n) respiratory system." ; dcterms:contributor ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vein endothelial cell of respiratory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0002543 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:CL_4033013 obo:IAO_0000115 "A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1." ; dcterms:contributor ; oboInOwl:creation_date "2023-02-02T11:17:04Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "suprabasal keratinocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000312 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010402 ] ) ] . obo:CL_4033015 obo:IAO_0000115 "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." ; dcterms:contributor ; dcterms:date "2023-03-02T14:38:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "retinal astroglia" ; oboInOwl:inSubset cl:eye_upper_slim ; a owl:Class ; rdfs:comment "In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive." ; rdfs:label "retinal astrocyte" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:CL_4033017 obo:IAO_0000115 "A smooth muscle cell that is part of a bronchiole." ; dcterms:contributor , ; dcterms:date "2023-03-16T09:38:17Z"^^xsd:dateTime ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchiolar smooth muscle cell" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:CL_4033018 obo:IAO_0000115 "A megakaryocyte that is resident in the lung connective tissue." ; dcterms:contributor , ; dcterms:date "2023-03-16T11:31:23Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "lung MKs" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lung megakaryocyte" ; rdfs:subClassOf obo:CL_0000556 . obo:CL_4033020 obo:IAO_0000115 "A mucus secreting cell that is part of a submucosal gland of the trachea." ; dcterms:contributor , ; dcterms:date "2023-03-16T13:03:13Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "tracheal submucosal gland mucous cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mucus secreting cell of trachea gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005203 ] ) ] . obo:CL_4033022 obo:IAO_0000115 "A mucus secreting cell of a submucosal gland of the bronchus." ; dcterms:contributor , ; dcterms:date "2023-03-16T15:12:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "bronchial gland mucous cell" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mucus secreting cell of bronchus submucosal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410043 ] ) ] . obo:CL_4033037 obo:IAO_0000115 "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." ; dcterms:contributor ; dcterms:date "2023-04-20T10:55:50Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "mucus secreting cell of tracheobronchial tree submucosal gland" ; rdfs:subClassOf obo:CL_0002202 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000319 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410077 ] ) ] . obo:CL_4033049 obo:IAO_0000115 "A taste receptor cell that is part of a taste bud of a tongue." ; dcterms:contributor ; dcterms:date "2023-05-03T07:59:58Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "gustatory cell of tongue" ; a owl:Class ; rdfs:label "taste receptor cell of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014451 ] ) ] . obo:CL_4040002 obo:IAO_0000115 "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." ; dcterms:contributor ; dcterms:date "2023-04-03T15:15:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "enteric glial cell" ; oboInOwl:hasRelatedSynonym "enteric glia" ; a owl:Class ; rdfs:label "enteroglial cell" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002292 ; owl:someValuesFrom obo:PR_000007939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:CL_4040003 obo:IAO_0000115 "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." ; dcterms:contributor ; dcterms:date "2023-06-02T09:19:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "fetal alveolar pre-type II epithelial cell", "fetal pre-type 2 pneumocyte", "fetal pre-type II alveolar epithelial cell" ; oboInOwl:note "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350)." ; a owl:Class ; rdfs:label "fetal pre-type II pneumocyte" ; rdfs:subClassOf obo:CL_0000322 . obo:GO_0000002 obo:IAO_0000115 "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000002" ; a owl:Class ; rdfs:label "mitochondrial genome maintenance" ; rdfs:subClassOf obo:GO_0007005 . obo:GO_0000003 obo:IAO_0000115 "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." ; oboInOwl:hasAlternativeId "GO:0019952", "GO:0050876" ; oboInOwl:hasDbXref "Wikipedia:Reproduction" ; oboInOwl:hasExactSynonym "reproductive physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000003" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "reproduction" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0000016 obo:IAO_0000115 "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." ; oboInOwl:hasDbXref "EC:3.2.1.108", "MetaCyc:LACTASE-RXN", "RHEA:10076", "Reactome:R-HSA-189062", "Reactome:R-HSA-5658001" ; oboInOwl:hasExactSynonym "lactose galactohydrolase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0000016" ; a owl:Class ; rdfs:label "lactase activity" ; rdfs:subClassOf obo:GO_0004553 . obo:GO_0000018 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000018" ; a owl:Class ; rdfs:label "regulation of DNA recombination" ; rdfs:subClassOf obo:GO_0051052, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006310 ] ) ] . obo:GO_0000052 obo:IAO_0000115 "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." ; oboInOwl:hasExactSynonym "citrulline metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000052" ; a owl:Class ; rdfs:label "citrulline metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_0000070 obo:IAO_0000115 "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." ; oboInOwl:hasAlternativeId "GO:0016359" ; oboInOwl:hasExactSynonym "mitotic chromosome segregation" ; oboInOwl:hasNarrowSynonym "mitotic sister-chromatid adhesion release" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000070" ; oboInOwl:inSubset go:goslim_pombe ; a owl:Class ; rdfs:label "mitotic sister chromatid segregation" ; rdfs:subClassOf obo:GO_0000819, obo:GO_1903047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0098813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140014 ] ) ] . obo:GO_0000096 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." ; oboInOwl:hasExactSynonym "sulfur amino acid metabolism", "sulphur amino acid metabolic process", "sulphur amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000096" ; a owl:Class ; rdfs:label "sulfur amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006790, obo:GO_0019752, obo:GO_1901564 . obo:GO_0000226 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23114"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/23195"^^xsd:anyURI ; oboInOwl:hasExactSynonym "microtubule cytoskeleton organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "microtubule cytoskeleton organization and biogenesis" ; oboInOwl:id "GO:0000226" ; oboInOwl:inSubset go:goslim_pombe ; a owl:Class ; rdfs:label "microtubule cytoskeleton organization" ; rdfs:subClassOf obo:GO_0007010, obo:GO_0007017 . obo:GO_0000228 obo:IAO_0000115 "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." ; oboInOwl:hasNarrowSynonym "nuclear interphase chromosome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0000228" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic ; a owl:Class ; rdfs:label "nuclear chromosome" ; rdfs:subClassOf obo:GO_0005694, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ) ] . obo:GO_0000262 obo:IAO_0000115 "A chromosome found in the mitochondrion of a eukaryotic cell." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1186327184" ; oboInOwl:hasNarrowSynonym "mitochondrial DNA", "mtDNA" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "mitochondrial genome" ; oboInOwl:id "GO:0000262" ; a owl:Class ; rdfs:label "mitochondrial chromosome" ; rdfs:subClassOf obo:GO_0005694, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042645 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0000271 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." ; oboInOwl:hasExactSynonym "glycan biosynthesis", "glycan biosynthetic process", "polysaccharide anabolism", "polysaccharide biosynthesis", "polysaccharide formation", "polysaccharide synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000271" ; a owl:Class ; rdfs:label "polysaccharide biosynthetic process" ; rdfs:subClassOf obo:GO_0005976, obo:GO_0009059, obo:GO_0016051 . obo:GO_0000272 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." ; oboInOwl:hasAlternativeId "GO:0044244" ; oboInOwl:hasExactSynonym "polysaccharide breakdown", "polysaccharide catabolism", "polysaccharide degradation" ; oboInOwl:hasNarrowSynonym "multicellular organismal polysaccharide catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000272" ; a owl:Class ; rdfs:label "polysaccharide catabolic process" ; rdfs:subClassOf obo:GO_0005976, obo:GO_0009057, obo:GO_0016052 . obo:GO_0000278 obo:IAO_0000115 "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." ; oboInOwl:hasAlternativeId "GO:0007067" ; oboInOwl:hasDbXref "Wikipedia:Mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mitosis" ; oboInOwl:id "GO:0000278" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ; rdfs:label "mitotic cell cycle" ; rdfs:subClassOf obo:GO_0007049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0140014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0140014 ] ) ] . obo:GO_0000280 obo:IAO_0000115 "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "karyokinesis" ; oboInOwl:id "GO:0000280" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "nuclear division" ; rdfs:subClassOf obo:GO_0048285 . obo:GO_0000313 obo:IAO_0000115 "A ribosome contained within a subcellular membrane-bounded organelle." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0000313" ; a owl:Class ; rdfs:label "organellar ribosome" ; rdfs:subClassOf obo:GO_0005840, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005840 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043226 ] ) ] . obo:GO_0000323 obo:IAO_0000115 "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0000323" ; a owl:Class ; rdfs:label "lytic vacuole" ; rdfs:subClassOf obo:GO_0005773 . obo:GO_0000785 obo:IAO_0000115 "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." ; oboInOwl:hasAlternativeId "GO:0000789", "GO:0000790", "GO:0005717" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1615953555" ; oboInOwl:hasNarrowSynonym "cytoplasmic chromatin", "nuclear chromatin" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "chromosome scaffold" ; oboInOwl:id "GO:0000785" ; a owl:Class ; rdfs:comment "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ; rdfs:label "chromatin" ; rdfs:subClassOf obo:GO_0032993, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005694 ] . obo:GO_0000791 obo:IAO_0000115 "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22355"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0005719", "GO:0035327" ; oboInOwl:hasDbXref "NIF_Subcellular:sao445485807", "Wikipedia:Euchromatin" ; oboInOwl:hasExactSynonym "transcriptionally active chromatin" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "nuclear euchromatin" ; oboInOwl:id "GO:0000791" ; a owl:Class ; rdfs:label "euchromatin" ; rdfs:subClassOf obo:GO_0000785 . obo:GO_0000792 obo:IAO_0000115 "A compact and highly condensed form of chromatin that is refractory to transcription." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22355"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0005720", "GO:0035328" ; oboInOwl:hasDbXref "NIF_Subcellular:sao581845896", "Wikipedia:Heterochromatin" ; oboInOwl:hasExactSynonym "transcriptionally inactive chromatin", "transcriptionally silent chromatin" ; oboInOwl:hasNarrowSynonym "nuclear heterochromatin" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0000792" ; a owl:Class ; rdfs:label "heterochromatin" ; rdfs:subClassOf obo:GO_0000785 . obo:GO_0000819 obo:IAO_0000115 "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000819" ; a owl:Class ; rdfs:label "sister chromatid segregation" ; rdfs:subClassOf obo:GO_0051276, obo:GO_0098813 . obo:GO_0000820 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." ; oboInOwl:hasExactSynonym "regulation of glutamine family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000820" ; a owl:Class ; rdfs:label "regulation of glutamine family amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006521, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009064 ] ) ] . obo:GO_0000821 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." ; oboInOwl:hasExactSynonym "regulation of arginine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0000821" ; a owl:Class ; rdfs:label "regulation of arginine metabolic process" ; rdfs:subClassOf obo:GO_0000820, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006525 ] ) ] . obo:GO_0001501 obo:IAO_0000115 "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." ; oboInOwl:hasExactSynonym "skeletal development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001501" ; a owl:Class ; rdfs:label "skeletal system development" ; rdfs:subClassOf obo:GO_0048731 . obo:GO_0001503 obo:IAO_0000115 "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." ; oboInOwl:hasDbXref "Wikipedia:Ossification" ; oboInOwl:hasExactSynonym "bone biosynthesis", "bone formation", "osteogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001503" ; a owl:Class ; rdfs:comment "Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'." ; rdfs:label "ossification" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0001505 obo:IAO_0000115 "Any process that modulates levels of neurotransmitter." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001505" ; a owl:Class ; rdfs:label "regulation of neurotransmitter levels" ; rdfs:subClassOf obo:GO_0065008 . obo:GO_0001508 obo:IAO_0000115 "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." ; obo:RO_0002161 obo:NCBITaxon_4895 ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001508" ; a owl:Class ; rdfs:comment "Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so." ; rdfs:label "action potential" ; rdfs:subClassOf obo:GO_0042391 . obo:GO_0001523 obo:IAO_0000115 "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." ; oboInOwl:hasExactSynonym "retinoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001523" ; a owl:Class ; rdfs:label "retinoid metabolic process" ; rdfs:subClassOf obo:GO_0016101 . obo:GO_0001525 obo:IAO_0000115 "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." ; oboInOwl:hasDbXref "Wikipedia:Angiogenesis" ; oboInOwl:hasExactSynonym "blood vessel formation from pre-existing blood vessels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001525" ; a owl:Class ; rdfs:label "angiogenesis" ; rdfs:subClassOf obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048514 ] . obo:GO_0001539 obo:IAO_0000115 "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." ; oboInOwl:hasExactSynonym "ciliary/flagellar motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ciliary or bacterial-type flagellar motility" ; oboInOwl:id "GO:0001539" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ; rdfs:label "cilium or flagellum-dependent cell motility" ; rdfs:subClassOf obo:GO_0048870 . obo:GO_0001558 obo:IAO_0000115 "Any process that modulates the frequency, rate, extent or direction of cell growth." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001558" ; a owl:Class ; rdfs:label "regulation of cell growth" ; rdfs:subClassOf obo:GO_0040008, obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016049 ] ) ] . obo:GO_0001568 obo:IAO_0000115 "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001568" ; a owl:Class ; rdfs:label "blood vessel development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001944 ] . obo:GO_0001569 obo:IAO_0000115 "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." ; oboInOwl:hasBroadSynonym "patterning of blood vessels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001569" ; a owl:Class ; rdfs:label "branching involved in blood vessel morphogenesis" ; rdfs:subClassOf obo:GO_0048754, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0048754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048514 ] ) ] . obo:GO_0001573 obo:IAO_0000115 "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." ; oboInOwl:hasExactSynonym "ganglioside metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001573" ; a owl:Class ; rdfs:label "ganglioside metabolic process" ; rdfs:subClassOf obo:GO_0006672, obo:GO_0006687 . obo:GO_0001578 obo:IAO_0000115 "A process that results in a parallel arrangement of microtubules." ; oboInOwl:hasExactSynonym "microtubule bundling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001578" ; a owl:Class ; rdfs:label "microtubule bundle formation" ; rdfs:subClassOf obo:GO_0000226 . obo:GO_0001659 obo:IAO_0000115 "A homeostatic process in which an organism modulates its internal body temperature." ; oboInOwl:hasDbXref "Wikipedia:Thermoregulation" ; oboInOwl:hasExactSynonym "thermoregulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001659" ; a owl:Class ; rdfs:label "temperature homeostasis" ; rdfs:subClassOf obo:GO_0048871 . obo:GO_0001667 obo:IAO_0000115 "Cell migration that is accomplished by extension and retraction of a pseudopodium." ; oboInOwl:hasExactSynonym "ameboid cell migration", "amoeboid cell migration", "amoeboidal cell migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001667" ; a owl:Class ; rdfs:comment "Note that this term refers to a mode of migration rather than to any particular cell type." ; rdfs:label "ameboidal-type cell migration" ; rdfs:subClassOf obo:GO_0016477 . obo:GO_0001675 obo:IAO_0000115 "The formation of the acrosome from the spermatid Golgi." ; oboInOwl:hasExactSynonym "acrosome formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001675" ; a owl:Class ; rdfs:label "acrosome assembly" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0010927, obo:GO_0022412, obo:GO_0033363, obo:GO_0070925, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007286 ] . obo:GO_0001676 obo:IAO_0000115 "The chemical reactions and pathways involving a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons." ; oboInOwl:hasExactSynonym "long-chain fatty acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001676" ; a owl:Class ; rdfs:label "long-chain fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0006631 . obo:GO_0001696 obo:IAO_0000115 "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." ; oboInOwl:hasNarrowSynonym "hydrochloric acid secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001696" ; a owl:Class ; rdfs:label "gastric acid secretion" ; rdfs:subClassOf obo:GO_0022600, obo:GO_0046717 . obo:GO_0001701 obo:IAO_0000115 "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001701" ; a owl:Class ; rdfs:label "in utero embryonic development" ; rdfs:subClassOf obo:GO_0043009 . obo:GO_0001704 obo:IAO_0000115 "The formation of the ectoderm, mesoderm and endoderm during gastrulation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001704" ; a owl:Class ; rdfs:label "formation of primary germ layer" ; rdfs:subClassOf obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007369 ] . obo:GO_0001705 obo:IAO_0000115 "The formation of ectoderm during gastrulation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001705" ; a owl:Class ; rdfs:label "ectoderm formation" ; rdfs:subClassOf obo:GO_0001704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007398 ] . obo:GO_0001706 obo:IAO_0000115 "The formation of the endoderm during gastrulation." ; oboInOwl:hasNarrowSynonym "endoblast formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001706" ; a owl:Class ; rdfs:label "endoderm formation" ; rdfs:subClassOf obo:GO_0001704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007492 ] . obo:GO_0001707 obo:IAO_0000115 "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001707" ; a owl:Class ; rdfs:label "mesoderm formation" ; rdfs:subClassOf obo:GO_0001704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048332 ] . obo:GO_0001763 obo:IAO_0000115 "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." ; oboInOwl:hasExactSynonym "branching morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001763" ; a owl:Class ; rdfs:label "morphogenesis of a branching structure" ; rdfs:subClassOf obo:GO_0009653, obo:GO_0032501 . obo:GO_0001764 obo:IAO_0000115 "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." ; oboInOwl:hasDbXref "Wikipedia:Neural_development#Neuron_migration", "Wikipedia:Neuron_migration" ; oboInOwl:hasExactSynonym "neuron chemotaxis", "neuronal migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "neuron guidance" ; oboInOwl:id "GO:0001764" ; a owl:Class ; rdfs:label "neuron migration" ; rdfs:subClassOf obo:GO_0016477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048699 ] . obo:GO_0001773 obo:IAO_0000115 "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001773" ; a owl:Class ; rdfs:label "myeloid dendritic cell activation" ; rdfs:subClassOf obo:GO_0002274 . obo:GO_0001775 obo:IAO_0000115 "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24416"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001775" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cell activation" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0032501 . obo:GO_0001816 obo:IAO_0000115 "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19116"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0042032", "GO:0042089", "GO:0042107", "GO:0050663" ; oboInOwl:hasNarrowSynonym "cytokine biosynthetic process", "cytokine metabolic process", "cytokine secretion", "interferon production", "interferon secretion", "interleukin production", "interleukin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001816" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "cytokine production" ; rdfs:subClassOf obo:GO_0010467, obo:GO_0032501 . obo:GO_0001817 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of production of a cytokine." ; oboInOwl:hasAlternativeId "GO:0042035", "GO:0050707" ; oboInOwl:hasExactSynonym "regulation of cytokine anabolism", "regulation of cytokine biosynthesis", "regulation of cytokine formation", "regulation of cytokine synthesis" ; oboInOwl:hasNarrowSynonym "regulation of cytokine biosynthetic process", "regulation of cytokine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001817" ; a owl:Class ; rdfs:label "regulation of cytokine production" ; rdfs:subClassOf obo:GO_0010468, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001816 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:GO_0001818 obo:IAO_0000115 "Any process that stops, prevents, or reduces the rate of production of a cytokine." ; oboInOwl:hasAlternativeId "GO:0042036", "GO:0050710" ; oboInOwl:hasExactSynonym "down regulation of cytokine biosynthetic process", "down regulation of cytokine production", "down-regulation of cytokine biosynthetic process", "down-regulation of cytokine production", "downregulation of cytokine biosynthetic process", "downregulation of cytokine production", "negative regulation of cytokine anabolism", "negative regulation of cytokine biosynthesis", "negative regulation of cytokine formation", "negative regulation of cytokine synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of cytokine biosynthetic process", "inhibition of cytokine production", "negative regulation of cytokine biosynthetic process", "negative regulation of cytokine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001818" ; a owl:Class ; rdfs:label "negative regulation of cytokine production" ; rdfs:subClassOf obo:GO_0001817, obo:GO_0010629, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001816 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:GO_0001819 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of production of a cytokine." ; oboInOwl:hasAlternativeId "GO:0042108", "GO:0050715" ; oboInOwl:hasExactSynonym "up regulation of cytokine production", "up-regulation of cytokine production", "upregulation of cytokine production" ; oboInOwl:hasNarrowSynonym "activation of cytokine production", "positive regulation of cytokine biosynthetic process", "positive regulation of cytokine secretion", "stimulation of cytokine production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001819" ; a owl:Class ; rdfs:label "positive regulation of cytokine production" ; rdfs:subClassOf obo:GO_0001817, obo:GO_0010628, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001816 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001816 ] ) ] . obo:GO_0001820 obo:IAO_0000115 "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." ; oboInOwl:hasExactSynonym "5-HT secretion", "5-hydroxytryptamine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "serotonin release" ; oboInOwl:id "GO:0001820" ; a owl:Class ; rdfs:label "serotonin secretion" ; rdfs:subClassOf obo:GO_0006837, obo:GO_0023061 . obo:GO_0001821 obo:IAO_0000115 "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001821" ; a owl:Class ; rdfs:label "histamine secretion" ; rdfs:subClassOf obo:GO_0046903, obo:GO_0051608 . obo:GO_0001838 obo:IAO_0000115 "The morphogenesis of an embryonic epithelium into a tube-shaped structure." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001838" ; a owl:Class ; rdfs:label "embryonic epithelial tube formation" ; rdfs:subClassOf obo:GO_0072175, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016331 ] . obo:GO_0001841 obo:IAO_0000115 "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." ; oboInOwl:hasAlternativeId "GO:0001679" ; oboInOwl:hasDbXref "Wikipedia:Neurulation" ; oboInOwl:hasExactSynonym "neural tube morphogenesis", "neurulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001841" ; a owl:Class ; rdfs:label "neural tube formation" ; rdfs:subClassOf obo:GO_0001838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0021915 ] . obo:GO_0001843 obo:IAO_0000115 "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001843" ; a owl:Class ; rdfs:label "neural tube closure" ; rdfs:subClassOf obo:GO_0060606, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014020 ] . obo:GO_0001894 obo:IAO_0000115 "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." ; oboInOwl:hasNarrowSynonym "tissue maintenance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001894" ; a owl:Class ; rdfs:label "tissue homeostasis" ; rdfs:subClassOf obo:GO_0060249, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048871 ] . obo:GO_0001906 obo:IAO_0000115 "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "necrosis" ; oboInOwl:id "GO:0001906" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cell killing" ; rdfs:subClassOf obo:GO_0009987 ; owl:disjointWith obo:GO_0044848 . obo:GO_0001909 obo:IAO_0000115 "The directed killing of a target cell by a leukocyte." ; oboInOwl:hasExactSynonym "immune cell mediated cell death", "immune cell mediated cell killing", "immune cell mediated cytotoxicity", "leucocyte mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001909" ; a owl:Class ; rdfs:comment "Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system." ; rdfs:label "leukocyte mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001906, obo:GO_0002443 . obo:GO_0001910 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." ; oboInOwl:hasExactSynonym "regulation of immune cell mediated cell death", "regulation of immune cell mediated cell killing", "regulation of immune cell mediated cytotoxicity", "regulation of leucocyte mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001910" ; a owl:Class ; rdfs:label "regulation of leukocyte mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0002703, obo:GO_0031341, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001909 ] ) ] . obo:GO_0001911 obo:IAO_0000115 "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." ; oboInOwl:hasExactSynonym "down regulation of leukocyte mediated cytotoxicity", "down-regulation of leukocyte mediated cytotoxicity", "downregulation of leukocyte mediated cytotoxicity", "negative regulation of immune cell mediated cytotoxicity", "negative regulation of leucocyte mediated cytotoxicity" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001911" ; a owl:Class ; rdfs:label "negative regulation of leukocyte mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001910, obo:GO_0002704, obo:GO_0031342, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001909 ] ) ] . obo:GO_0001912 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." ; oboInOwl:hasExactSynonym "positive regulation of immune cell mediated cytotoxicity", "positive regulation of leucocyte mediated cytotoxicity", "up regulation of leukocyte mediated cytotoxicity", "up-regulation of leukocyte mediated cytotoxicity", "upregulation of leukocyte mediated cytotoxicity" ; oboInOwl:hasNarrowSynonym "activation of leukocyte mediated cytotoxicity", "stimulation of leukocyte mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001912" ; a owl:Class ; rdfs:label "positive regulation of leukocyte mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001910, obo:GO_0002705, obo:GO_0031343, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001909 ] ) ] . obo:GO_0001944 obo:IAO_0000115 "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "vascular system development" ; oboInOwl:id "GO:0001944" ; a owl:Class ; rdfs:label "vasculature development" ; rdfs:subClassOf obo:GO_0048731, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0072359 ] . obo:GO_0001956 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." ; oboInOwl:hasExactSynonym "up regulation of neurotransmitter secretion", "up-regulation of neurotransmitter secretion", "upregulation of neurotransmitter secretion" ; oboInOwl:hasNarrowSynonym "activation of neurotransmitter secretion", "stimulation of neurotransmitter secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001956" ; a owl:Class ; rdfs:label "positive regulation of neurotransmitter secretion" ; rdfs:subClassOf obo:GO_0046928, obo:GO_0050806, obo:GO_0051590, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007269 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007269 ] ) ] . obo:GO_0001957 obo:IAO_0000115 "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." ; oboInOwl:hasDbXref "Wikipedia:Intramembranous_ossification" ; oboInOwl:hasNarrowSynonym "dermal ossification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intramembranous bone ossification" ; oboInOwl:id "GO:0001957" ; a owl:Class ; rdfs:comment "An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division." ; rdfs:label "intramembranous ossification" ; rdfs:subClassOf obo:GO_0036072 . obo:GO_0001958 obo:IAO_0000115 "Replacement ossification wherein bone tissue replaces cartilage." ; oboInOwl:hasDbXref "Wikipedia:Endochondral_ossification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001958" ; a owl:Class ; rdfs:label "endochondral ossification" ; rdfs:subClassOf obo:GO_0036075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060350 ] . obo:GO_0001959 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." ; oboInOwl:hasExactSynonym "regulation of cytokine and chemokine mediated signaling pathway", "regulation of cytokine mediated signaling pathway", "regulation of cytokine mediated signalling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001959" ; a owl:Class ; rdfs:label "regulation of cytokine-mediated signaling pathway" ; rdfs:subClassOf obo:GO_0009966, obo:GO_0060759, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019221 ] ) ] . obo:GO_0001960 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." ; oboInOwl:hasExactSynonym "down regulation of cytokine mediated signaling pathway", "down-regulation of cytokine mediated signaling pathway", "downregulation of cytokine mediated signaling pathway", "negative regulation of cytokine and chemokine mediated signaling pathway", "negative regulation of cytokine mediated signaling pathway", "negative regulation of cytokine mediated signalling pathway" ; oboInOwl:hasNarrowSynonym "inhibition of cytokine mediated signaling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001960" ; a owl:Class ; rdfs:label "negative regulation of cytokine-mediated signaling pathway" ; rdfs:subClassOf obo:GO_0001959, obo:GO_0009968, obo:GO_0060761, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019221 ] ) ] . obo:GO_0001961 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." ; oboInOwl:hasExactSynonym "positive regulation of cytokine and chemokine mediated signaling pathway", "positive regulation of cytokine mediated signaling pathway", "positive regulation of cytokine mediated signalling pathway", "up regulation of cytokine mediated signaling pathway", "up-regulation of cytokine mediated signaling pathway", "upregulation of cytokine mediated signaling pathway" ; oboInOwl:hasNarrowSynonym "activation of cytokine mediated signaling pathway", "stimulation of cytokine mediated signaling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001961" ; a owl:Class ; rdfs:label "positive regulation of cytokine-mediated signaling pathway" ; rdfs:subClassOf obo:GO_0001959, obo:GO_0009967, obo:GO_0060760, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019221 ] ) ] . obo:GO_0001964 obo:IAO_0000115 "An action or movement due to the application of a sudden unexpected stimulus." ; oboInOwl:hasDbXref "Wikipedia:Startle_reaction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0001964" ; a owl:Class ; rdfs:label "startle response" ; rdfs:subClassOf obo:GO_0009605, obo:GO_0050905 . obo:GO_0001976 obo:IAO_0000115 "The regulation of blood pressure mediated by detection of stimuli and a neurological response." ; oboInOwl:hasExactSynonym "blood pressure regulation by neurological process", "neurological process involved in regulation of systemic arterial blood pressure", "neurological system process involved in regulation of systemic arterial blood pressure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "fast control of arterial pressure" ; oboInOwl:id "GO:0001976" ; a owl:Class ; rdfs:label "nervous system process involved in regulation of systemic arterial blood pressure" ; rdfs:subClassOf obo:GO_0050877, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050877 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003073 ] ) ] . obo:GO_0001977 obo:IAO_0000115 "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "renal blood volume control of blood pressure", "renal regulation of blood volume" ; oboInOwl:id "GO:0001977" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "renal system process involved in regulation of blood volume" ; rdfs:subClassOf obo:GO_0003071, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050878 ] . obo:GO_0001990 obo:IAO_0000115 "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." ; oboInOwl:hasExactSynonym "blood pressure regulation by hormone", "hormonal regulation of blood pressure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "hormonal control of blood pressure" ; oboInOwl:id "GO:0001990" ; a owl:Class ; rdfs:label "regulation of systemic arterial blood pressure by hormone" ; rdfs:subClassOf obo:GO_0003044, obo:GO_0050886 . obo:GO_0001992 obo:IAO_0000115 "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." ; oboInOwl:hasExactSynonym "blood pressure regulation by vasopressin" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "vasopressin control of blood pressure" ; oboInOwl:id "GO:0001992" ; a owl:Class ; rdfs:label "regulation of systemic arterial blood pressure by vasopressin" ; rdfs:subClassOf obo:GO_0001990 . obo:GO_0002009 obo:IAO_0000115 "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." ; oboInOwl:hasExactSynonym "epithelium morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002009" ; a owl:Class ; rdfs:label "morphogenesis of an epithelium" ; rdfs:subClassOf obo:GO_0048729, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060429 ] . obo:GO_0002016 obo:IAO_0000115 "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." ; oboInOwl:hasExactSynonym "renin-angiotensin regulation of blood volume" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "renin-angiotensin control of body fluid levels" ; oboInOwl:id "GO:0002016" ; a owl:Class ; rdfs:label "regulation of blood volume by renin-angiotensin" ; rdfs:subClassOf obo:GO_0003081 . obo:GO_0002018 obo:IAO_0000115 "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "renin-angiotensin control of aldosterone production" ; oboInOwl:id "GO:0002018" ; a owl:Class ; rdfs:label "renin-angiotensin regulation of aldosterone production" ; rdfs:subClassOf obo:GO_0003071, obo:GO_2000858, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0003014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035932 ] ) ] . obo:GO_0002027 obo:IAO_0000115 "Any process that modulates the frequency or rate of heart contraction." ; oboInOwl:hasExactSynonym "cardiac chronotropy", "regulation of heart contraction rate", "regulation of rate of heart contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002027" ; a owl:Class ; rdfs:label "regulation of heart rate" ; rdfs:subClassOf obo:GO_0008016, obo:GO_0065008 . obo:GO_0002053 obo:IAO_0000115 "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." ; oboInOwl:hasExactSynonym "up regulation of mesenchymal cell proliferation", "up-regulation of mesenchymal cell proliferation", "upregulation of mesenchymal cell proliferation" ; oboInOwl:hasNarrowSynonym "activation of mesenchymal cell proliferation", "stimulation of mesenchymal cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002053" ; a owl:Class ; rdfs:label "positive regulation of mesenchymal cell proliferation" ; rdfs:subClassOf obo:GO_0008284, obo:GO_0010464, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010463 ] ) ] . obo:GO_0002087 obo:IAO_0000115 "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." ; oboInOwl:hasExactSynonym "neurological control of breathing", "regulation of respiratory gaseous exchange by neurological system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002087" ; a owl:Class ; rdfs:label "regulation of respiratory gaseous exchange by nervous system process" ; rdfs:subClassOf obo:GO_0044065, obo:GO_0050877 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050877 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:GO_0002185 obo:IAO_0000115 "A protein complex having creatine kinase activity." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2011-06-14T02:12:19Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0002185" ; a owl:Class ; rdfs:label "creatine kinase complex" ; rdfs:subClassOf obo:GO_0061695 . obo:GO_0002187 obo:IAO_0000115 "An octomeric protein complex having creatine kinase activity." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2011-06-14T02:15:29Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0002187" ; a owl:Class ; rdfs:label "mitochondrial creatine kinase complex" ; rdfs:subClassOf obo:GO_0002185, obo:GO_0098798 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0002185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0002200 obo:IAO_0000115 "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002200" ; a owl:Class ; rdfs:comment "Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification." ; rdfs:label "somatic diversification of immune receptors" ; rdfs:subClassOf obo:GO_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002520 ] . obo:GO_0002204 obo:IAO_0000115 "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "somatic recombination of antibody genes during immune response", "somatic recombination of immunoglobulin genes during immune response" ; oboInOwl:id "GO:0002204" ; a owl:Class ; rdfs:label "somatic recombination of immunoglobulin genes involved in immune response" ; rdfs:subClassOf obo:GO_0002208, obo:GO_0016447 . obo:GO_0002208 obo:IAO_0000115 "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "somatic diversification of antibodies during immune response", "somatic diversification of immunoglobulins during immune response" ; oboInOwl:id "GO:0002208" ; a owl:Class ; rdfs:label "somatic diversification of immunoglobulins involved in immune response" ; rdfs:subClassOf obo:GO_0016445, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002381 ] . obo:GO_0002225 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." ; oboInOwl:hasExactSynonym "antimicrobial peptide induction", "up regulation of antimicrobial peptide production", "up-regulation of antimicrobial peptide production", "upregulation of antimicrobial peptide production" ; oboInOwl:hasNarrowSynonym "activation of antimicrobial peptide production", "stimulation of antimicrobial peptide production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002225" ; a owl:Class ; rdfs:label "positive regulation of antimicrobial peptide production" ; rdfs:subClassOf obo:GO_0002702, obo:GO_0002760, obo:GO_0002784, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002775 ] ) ] . obo:GO_0002228 obo:IAO_0000115 "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." ; oboInOwl:hasExactSynonym "NK cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002228" ; a owl:Class ; rdfs:label "natural killer cell mediated immunity" ; rdfs:subClassOf obo:GO_0002449, obo:GO_0045087 . obo:GO_0002232 obo:IAO_0000115 "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "immune cell chemotaxis during inflammatory response", "leucocyte chemotaxis during inflammatory response", "leukocyte chemotaxis during inflammatory response" ; oboInOwl:id "GO:0002232" ; a owl:Class ; rdfs:label "leukocyte chemotaxis involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002523, obo:GO_0030595 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030595 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002233 obo:IAO_0000115 "The movement of an immune cell in response to an external stimulus a part of an immune response." ; oboInOwl:hasExactSynonym "immune cell chemotaxis during immune response", "leucocyte chemotaxis during immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002233" ; a owl:Class ; rdfs:label "leukocyte chemotaxis involved in immune response" ; rdfs:subClassOf obo:GO_0002522, obo:GO_0030595 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030595 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002244 obo:IAO_0000115 "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." ; oboInOwl:hasExactSynonym "haematopoietic progenitor cell differentiation", "haemopoietic progenitor cell differentiation", "hemopoietic progenitor cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002244" ; a owl:Class ; rdfs:label "hematopoietic progenitor cell differentiation" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030097 ] . obo:GO_0002246 obo:IAO_0000115 "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "healing during inflammatory response", "inflammatory response wound healing" ; oboInOwl:id "GO:0002246" ; a owl:Class ; rdfs:label "wound healing involved in inflammatory response" ; rdfs:subClassOf obo:GO_0042060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0090594 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002250 obo:IAO_0000115 "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." ; oboInOwl:hasDbXref "Wikipedia:Adaptive_immune_system" ; oboInOwl:hasExactSynonym "acquired immune response", "immune memory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002250" ; a owl:Class ; rdfs:label "adaptive immune response" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0002251 obo:IAO_0000115 "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." ; oboInOwl:hasExactSynonym "immune response in organ or tissue" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002251" ; a owl:Class ; rdfs:label "organ or tissue specific immune response" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0002252 obo:IAO_0000115 "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/18737"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002252" ; a owl:Class ; rdfs:label "immune effector process" ; rdfs:subClassOf obo:GO_0002376 . obo:GO_0002253 obo:IAO_0000115 "Any process that initiates an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002253" ; a owl:Class ; rdfs:label "activation of immune response" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0050778 . obo:GO_0002262 obo:IAO_0000115 "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002262" ; a owl:Class ; rdfs:label "myeloid cell homeostasis" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0048872 . obo:GO_0002263 obo:IAO_0000115 "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell activation during immune response" ; oboInOwl:id "GO:0002263" ; a owl:Class ; rdfs:label "cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0001775, obo:GO_0002252, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002269 obo:IAO_0000115 "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "immune cell activation during inflammatory response", "leukocyte activation during inflammatory response" ; oboInOwl:id "GO:0002269" ; a owl:Class ; rdfs:label "leukocyte activation involved in inflammatory response" ; rdfs:subClassOf obo:GO_0045321, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045321 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002274 obo:IAO_0000115 "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." ; oboInOwl:hasExactSynonym "myeloid leucocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002274" ; a owl:Class ; rdfs:label "myeloid leukocyte activation" ; rdfs:subClassOf obo:GO_0045321 . obo:GO_0002275 obo:IAO_0000115 "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "myeloid cell activation during immune response" ; oboInOwl:id "GO:0002275" ; a owl:Class ; rdfs:label "myeloid cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002274, obo:GO_0002366 . obo:GO_0002277 obo:IAO_0000115 "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "myeloid dendritic cell activation during immune response" ; oboInOwl:id "GO:0002277" ; a owl:Class ; rdfs:label "myeloid dendritic cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0001773, obo:GO_0002275 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001773 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002284 obo:IAO_0000115 "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "myeloid dendritic cell differentiation during immune response" ; oboInOwl:id "GO:0002284" ; a owl:Class ; rdfs:label "myeloid dendritic cell differentiation involved in immune response" ; rdfs:subClassOf obo:GO_0002277, obo:GO_0043011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002285 obo:IAO_0000115 "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "lymphocyte activation during immune response" ; oboInOwl:id "GO:0002285" ; a owl:Class ; rdfs:label "lymphocyte activation involved in immune response" ; rdfs:subClassOf obo:GO_0002366, obo:GO_0046649 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0046649 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002286 obo:IAO_0000115 "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "T cell activation during immune response", "T lymphocyte activation during immune response", "T-cell activation during immune response", "T-lymphocyte activation during immune response" ; oboInOwl:id "GO:0002286" ; a owl:Class ; rdfs:label "T cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002285, obo:GO_0042110 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042110 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002290 obo:IAO_0000115 "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gamma-delta T cell activation during immune response", "gamma-delta T lymphocyte activation during immune response", "gamma-delta T-cell activation during immune response", "gamma-delta T-lymphocyte activation during immune response" ; oboInOwl:id "GO:0002290" ; a owl:Class ; rdfs:label "gamma-delta T cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002286, obo:GO_0046629 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0046629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002292 obo:IAO_0000115 "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "T cell development involved in immune response", "T cell differentiation during immune response", "T lymphocyte differentiation during immune response", "T-cell differentiation during immune response", "T-lymphocyte differentiation during immune response" ; oboInOwl:id "GO:0002292" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "T cell differentiation involved in immune response" ; rdfs:subClassOf obo:GO_0002286, obo:GO_0030217 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030217 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002303 obo:IAO_0000115 "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gamma-delta T cell development involved in immune response", "gamma-delta T cell differentiation during immune response", "gamma-delta T lymphocyte differentiation during immune response", "gamma-delta T-cell differentiation during immune response", "gamma-delta T-lymphocyte differentiation during immune response" ; oboInOwl:id "GO:0002303" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "gamma-delta T cell differentiation involved in immune response" ; rdfs:subClassOf obo:GO_0002290, obo:GO_0002292, obo:GO_0042492 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002309 obo:IAO_0000115 "The expansion of a T cell population by cell division as part of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "T cell proliferation during immune response", "T lymphocyte proliferation during immune response", "T-cell proliferation during immune response", "T-lymphocyte proliferation during immune response" ; oboInOwl:id "GO:0002309" ; a owl:Class ; rdfs:label "T cell proliferation involved in immune response" ; rdfs:subClassOf obo:GO_0002286, obo:GO_0042098 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002312 obo:IAO_0000115 "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "B cell activation during immune response", "B lymphocyte activation during immune response", "B-cell activation during immune response", "B-lymphocyte activation during immune response" ; oboInOwl:id "GO:0002312" ; a owl:Class ; rdfs:label "B cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002285, obo:GO_0042113 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042113 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002313 obo:IAO_0000115 "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mature B cell development involved in immune response", "mature B cell differentiation during immune response", "mature B lymphocyte differentiation during immune response", "mature B-cell differentiation during immune response", "mature B-lymphocyte differentiation during immune response" ; oboInOwl:id "GO:0002313" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "mature B cell differentiation involved in immune response" ; rdfs:subClassOf obo:GO_0002312, obo:GO_0002335 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0002335 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002319 obo:IAO_0000115 "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." ; oboInOwl:hasExactSynonym "memory B lymphocyte differentiation", "memory B-cell differentiation", "memory B-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "memory B cell development" ; oboInOwl:id "GO:0002319" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "memory B cell differentiation" ; rdfs:subClassOf obo:GO_0002313, obo:GO_0090715 . obo:GO_0002322 obo:IAO_0000115 "The expansion of a B cell population by cell division following B cell activation during an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "B cell proliferation during immune response", "B lymphocyte proliferation during immune response", "B-cell proliferation during immune response", "B-lymphocyte proliferation during immune response" ; oboInOwl:id "GO:0002322" ; a owl:Class ; rdfs:label "B cell proliferation involved in immune response" ; rdfs:subClassOf obo:GO_0002312, obo:GO_0042100 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042100 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002335 obo:IAO_0000115 "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." ; oboInOwl:hasExactSynonym "mature B lymphocyte differentiation", "mature B-cell differentiation", "mature B-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mature cell development" ; oboInOwl:id "GO:0002335" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "mature B cell differentiation" ; rdfs:subClassOf obo:GO_0030183 . obo:GO_0002339 obo:IAO_0000115 "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." ; oboInOwl:hasExactSynonym "B lymphocyte selection", "B-cell selection", "B-lymphocyte selection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002339" ; a owl:Class ; rdfs:label "B cell selection" ; rdfs:subClassOf obo:GO_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030183 ] . obo:GO_0002343 obo:IAO_0000115 "Any B cell selection process that occurs in the periphery." ; oboInOwl:hasExactSynonym "peripheral B lymphocyte selection", "peripheral B-cell selection", "peripheral B-lymphocyte selection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002343" ; a owl:Class ; rdfs:label "peripheral B cell selection" ; rdfs:subClassOf obo:GO_0002339 . obo:GO_0002344 obo:IAO_0000115 "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." ; oboInOwl:hasExactSynonym "B lymphocyte affinity maturation", "B-cell affinity maturation", "B-lymphocyte affinity maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002344" ; a owl:Class ; rdfs:label "B cell affinity maturation" ; rdfs:subClassOf obo:GO_0002343, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002381 ] . obo:GO_0002349 obo:IAO_0000115 "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "histamine production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002349" ; a owl:Class ; rdfs:label "histamine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002532 . obo:GO_0002351 obo:IAO_0000115 "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "serotonin production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002351" ; a owl:Class ; rdfs:label "serotonin production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002532 . obo:GO_0002366 obo:IAO_0000115 "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "immune cell activation during immune response", "leucocyte activation during immune response", "leukocyte activation during immune response" ; oboInOwl:id "GO:0002366" ; a owl:Class ; rdfs:label "leukocyte activation involved in immune response" ; rdfs:subClassOf obo:GO_0002263, obo:GO_0045321 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045321 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002367 obo:IAO_0000115 "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasAlternativeId "GO:0002374", "GO:0002375" ; oboInOwl:hasNarrowSynonym "cytokine biosynthetic process involved in immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cytokine production during immune response", "cytokine secretion during immune response", "cytokine secretion involved in immune response" ; oboInOwl:id "GO:0002367" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "cytokine production involved in immune response" ; rdfs:subClassOf obo:GO_0001816, obo:GO_0002440, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001816 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002376 obo:IAO_0000115 "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." ; obo:RO_0002161 obo:NCBITaxon_4895 ; oboInOwl:hasDbXref "Wikipedia:Immune_system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002376" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_mouse, go:goslim_pir ; a owl:Class ; rdfs:comment "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501)." ; rdfs:label "immune system process" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0002377 obo:IAO_0000115 "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasAlternativeId "GO:0002378", "GO:0048305" ; oboInOwl:hasExactSynonym "antibody production" ; oboInOwl:hasNarrowSynonym "immunoglobulin biosynthetic process", "immunoglobulin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002377" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "immunoglobulin production" ; rdfs:subClassOf obo:GO_0002440 . obo:GO_0002381 obo:IAO_0000115 "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasAlternativeId "GO:0002379", "GO:0002380" ; oboInOwl:hasExactSynonym "immunoglobulin production involved in immunoglobulin mediated immune response" ; oboInOwl:hasNarrowSynonym "immunoglobulin biosynthetic process involved in immune response", "immunoglobulin secretion involved in immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "antibody production during immune response", "antibody secretion during immune response", "immunoglobulin production during immune response", "immunoglobulin production involved in immune response" ; oboInOwl:id "GO:0002381" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "immunoglobulin production involved in immunoglobulin-mediated immune response" ; rdfs:subClassOf obo:GO_0002377, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0002377 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016064 ] ) ] . obo:GO_0002384 obo:IAO_0000115 "An immune response taking place in the liver." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002384" ; a owl:Class ; rdfs:label "hepatic immune response" ; rdfs:subClassOf obo:GO_0002251 . obo:GO_0002440 obo:IAO_0000115 "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "production of cellular mediator of immune response" ; oboInOwl:id "GO:0002440" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "production of molecular mediator of immune response" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0010467 . obo:GO_0002441 obo:IAO_0000115 "The regulated release of histamine by a cell as part of an inflammatory response." ; oboInOwl:hasBroadSynonym "histamine secretion involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002441" ; a owl:Class ; rdfs:label "histamine secretion involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001821, obo:GO_0046879, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002349 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002442 obo:IAO_0000115 "The regulated release of serotonin by a cell as part of an inflammatory response." ; oboInOwl:hasBroadSynonym "serotonin secretion involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "serotonin release involved in inflammatory response" ; oboInOwl:id "GO:0002442" ; a owl:Class ; rdfs:label "serotonin secretion involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001820, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002351 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002443 obo:IAO_0000115 "Any process involved in the carrying out of an immune response by a leukocyte." ; oboInOwl:hasAlternativeId "GO:0019723", "GO:0042087" ; oboInOwl:hasExactSynonym "immune cell effector process", "immune cell mediated immunity", "leucocyte immune effector process", "leucocyte mediated immunity", "leukocyte immune effector process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell-mediated immune response", "cellular immune response" ; oboInOwl:id "GO:0002443" ; a owl:Class ; rdfs:label "leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002252 . obo:GO_0002444 obo:IAO_0000115 "Any process involved in the carrying out of an immune response by a myeloid leukocyte." ; oboInOwl:hasExactSynonym "myeloid leucocyte immune effector process", "myeloid leucocyte mediated immunity", "myeloid leukocyte immune effector process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002444" ; a owl:Class ; rdfs:label "myeloid leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002443 . obo:GO_0002446 obo:IAO_0000115 "Any process involved in the carrying out of an immune response by a neutrophil." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002446" ; a owl:Class ; rdfs:label "neutrophil mediated immunity" ; rdfs:subClassOf obo:GO_0002444 . obo:GO_0002449 obo:IAO_0000115 "Any process involved in the carrying out of an immune response by a lymphocyte." ; oboInOwl:hasBroadSynonym "cell-mediated immunity", "cellular immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002449" ; a owl:Class ; rdfs:label "lymphocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002443 . obo:GO_0002456 obo:IAO_0000115 "Any process involved in the carrying out of an immune response by a T cell." ; oboInOwl:hasBroadSynonym "cell-mediated immunity", "cellular immune response" ; oboInOwl:hasExactSynonym "T lymphocyte mediated immunity", "T-cell mediated immunity", "T-lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002456" ; a owl:Class ; rdfs:label "T cell mediated immunity" ; rdfs:subClassOf obo:GO_0002449, obo:GO_0002460 . obo:GO_0002460 obo:IAO_0000115 "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002460" ; a owl:Class ; rdfs:label "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" ; rdfs:subClassOf obo:GO_0002250 . obo:GO_0002461 obo:IAO_0000115 "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." ; oboInOwl:hasExactSynonym "immune response-dependent tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002461" ; a owl:Class ; rdfs:label "tolerance induction dependent upon immune response" ; rdfs:subClassOf obo:GO_0002460, obo:GO_0002507 . obo:GO_0002465 obo:IAO_0000115 "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002465" ; a owl:Class ; rdfs:label "peripheral tolerance induction" ; rdfs:subClassOf obo:GO_0002461 . obo:GO_0002467 obo:IAO_0000115 "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002467" ; a owl:Class ; rdfs:label "germinal center formation" ; rdfs:subClassOf obo:GO_0002460, obo:GO_0048646 . obo:GO_0002504 obo:IAO_0000115 "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." ; oboInOwl:hasExactSynonym "peptide or polysaccharide antigen processing and presentation of via MHC class II" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002504" ; a owl:Class ; rdfs:label "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; rdfs:subClassOf obo:GO_0019882 . obo:GO_0002507 obo:IAO_0000115 "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002507" ; a owl:Class ; rdfs:label "tolerance induction" ; rdfs:subClassOf obo:GO_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002520 ] . obo:GO_0002520 obo:IAO_0000115 "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002520" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "immune system development" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0048731 . obo:GO_0002521 obo:IAO_0000115 "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ; oboInOwl:hasExactSynonym "immune cell differentiation", "leucocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002521" ; a owl:Class ; rdfs:label "leukocyte differentiation" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030097 ] . obo:GO_0002522 obo:IAO_0000115 "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." ; oboInOwl:hasExactSynonym "immune cell migration during immune response", "immune cell trafficking during immune response", "leucocyte migration during immune response", "leucocyte trafficking during immune response", "leukocyte trafficking during immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002522" ; a owl:Class ; rdfs:label "leukocyte migration involved in immune response" ; rdfs:subClassOf obo:GO_0002252, obo:GO_0050900, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050900 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0002523 obo:IAO_0000115 "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "immune cell migration during inflammatory response", "immune cell trafficking during inflammatory response", "leucocyte migration during inflammatory response", "leucocyte trafficking during inflammatory response", "leukocyte migration during inflammatory response", "leukocyte trafficking during inflammatory response" ; oboInOwl:id "GO:0002523" ; a owl:Class ; rdfs:label "leukocyte migration involved in inflammatory response" ; rdfs:subClassOf obo:GO_0050900, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050900 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002526 obo:IAO_0000115 "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002526" ; a owl:Class ; rdfs:label "acute inflammatory response" ; rdfs:subClassOf obo:GO_0006954 . obo:GO_0002532 obo:IAO_0000115 "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "production of molecular mediator involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "production of cellular mediator of acute inflammation" ; oboInOwl:id "GO:0002532" ; a owl:Class ; rdfs:label "production of molecular mediator involved in inflammatory response" ; rdfs:subClassOf obo:GO_0032501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] . obo:GO_0002534 obo:IAO_0000115 "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "cytokine production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002534" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "cytokine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001816, obo:GO_0002532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001816 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002536 obo:IAO_0000115 "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "oxidative burst during acute inflammatory response", "production of reactive oxygen species during acute inflammatory response", "respiratory burst involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002536" ; a owl:Class ; rdfs:label "respiratory burst involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002532, obo:GO_0002679 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045730 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0002538 obo:IAO_0000115 "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "arachidonic acid metabolite production involved in acute inflammatory response", "production of arachidonic acid metabolites involved in acute inflammatory response" ; oboInOwl:hasExactSynonym "production of arachidonic acid metabolites involved in inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002538" ; a owl:Class ; rdfs:label "arachidonic acid metabolite production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002532 . obo:GO_0002539 obo:IAO_0000115 "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ; oboInOwl:hasBroadSynonym "prostaglandin production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002539" ; a owl:Class ; rdfs:label "prostaglandin production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002538 . obo:GO_0002544 obo:IAO_0000115 "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002544" ; a owl:Class ; rdfs:label "chronic inflammatory response" ; rdfs:subClassOf obo:GO_0006954 . obo:GO_0002548 obo:IAO_0000115 "The movement of a monocyte in response to an external stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002548" ; a owl:Class ; rdfs:label "monocyte chemotaxis" ; rdfs:subClassOf obo:GO_0030595, obo:GO_0071674, obo:GO_0097529 . obo:GO_0002562 obo:IAO_0000115 "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002562" ; a owl:Class ; rdfs:label "somatic diversification of immune receptors via germline recombination within a single locus" ; rdfs:subClassOf obo:GO_0002200, obo:GO_0016444 . obo:GO_0002566 obo:IAO_0000115 "The process in which immune receptor genes are diversified through somatic mutation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002566" ; a owl:Class ; rdfs:label "somatic diversification of immune receptors via somatic mutation" ; rdfs:subClassOf obo:GO_0002200 . obo:GO_0002573 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." ; oboInOwl:hasExactSynonym "myeloid leucocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002573" ; a owl:Class ; rdfs:label "myeloid leukocyte differentiation" ; rdfs:subClassOf obo:GO_0002521, obo:GO_0030099 . obo:GO_0002574 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002574" ; a owl:Class ; rdfs:comment "Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220." ; rdfs:label "thrombocyte differentiation" ; rdfs:subClassOf obo:GO_0030099 . obo:GO_0002577 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002577" ; a owl:Class ; rdfs:label "regulation of antigen processing and presentation" ; rdfs:subClassOf obo:GO_0002682, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019882 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019882 ] ) ] . obo:GO_0002578 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." ; oboInOwl:hasExactSynonym "down regulation of antigen processing and presentation", "down-regulation of antigen processing and presentation", "downregulation of antigen processing and presentation" ; oboInOwl:hasNarrowSynonym "inhibition of antigen processing and presentation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002578" ; a owl:Class ; rdfs:label "negative regulation of antigen processing and presentation" ; rdfs:subClassOf obo:GO_0002577, obo:GO_0002683, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019882 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019882 ] ) ] . obo:GO_0002579 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." ; oboInOwl:hasExactSynonym "up regulation of antigen processing and presentation", "up-regulation of antigen processing and presentation", "upregulation of antigen processing and presentation" ; oboInOwl:hasNarrowSynonym "activation of antigen processing and presentation", "stimulation of antigen processing and presentation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002579" ; a owl:Class ; rdfs:label "positive regulation of antigen processing and presentation" ; rdfs:subClassOf obo:GO_0002577, obo:GO_0002684, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019882 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019882 ] ) ] . obo:GO_0002580 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." ; oboInOwl:hasExactSynonym "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002580" ; a owl:Class ; rdfs:label "regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; rdfs:subClassOf obo:GO_0002577, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002504 ] ) ] . obo:GO_0002581 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." ; oboInOwl:hasExactSynonym "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" ; oboInOwl:hasNarrowSynonym "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002581" ; a owl:Class ; rdfs:label "negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; rdfs:subClassOf obo:GO_0002578, obo:GO_0002580, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002504 ] ) ] . obo:GO_0002582 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." ; oboInOwl:hasExactSynonym "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II", "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; oboInOwl:hasNarrowSynonym "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002582" ; a owl:Class ; rdfs:label "positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" ; rdfs:subClassOf obo:GO_0002579, obo:GO_0002580, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002504 ] ) ] . obo:GO_0002634 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of germinal center formation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002634" ; a owl:Class ; rdfs:label "regulation of germinal center formation" ; rdfs:subClassOf obo:GO_0002822, obo:GO_0022603, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002467 ] ) ] . obo:GO_0002635 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." ; oboInOwl:hasExactSynonym "down regulation of germinal center formation", "down-regulation of germinal center formation", "downregulation of germinal center formation" ; oboInOwl:hasNarrowSynonym "inhibition of germinal center formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002635" ; a owl:Class ; rdfs:label "negative regulation of germinal center formation" ; rdfs:subClassOf obo:GO_0002634, obo:GO_0002823, obo:GO_0051093, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002467 ] ) ] . obo:GO_0002636 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of germinal center formation." ; oboInOwl:hasExactSynonym "up regulation of germinal center formation", "up-regulation of germinal center formation", "upregulation of germinal center formation" ; oboInOwl:hasNarrowSynonym "activation of germinal center formation", "stimulation of germinal center formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002636" ; a owl:Class ; rdfs:label "positive regulation of germinal center formation" ; rdfs:subClassOf obo:GO_0002634, obo:GO_0002824, obo:GO_0051094, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002467 ] ) ] . obo:GO_0002637 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of immunoglobulin production." ; oboInOwl:hasAlternativeId "GO:0002640", "GO:0051023" ; oboInOwl:hasExactSynonym "regulation of antibody production" ; oboInOwl:hasNarrowSynonym "regulation of immunoglobulin biosynthetic process", "regulation of immunoglobulin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002637" ; a owl:Class ; rdfs:label "regulation of immunoglobulin production" ; rdfs:subClassOf obo:GO_0002700, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002377 ] ) ] . obo:GO_0002638 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." ; oboInOwl:hasAlternativeId "GO:0002641", "GO:0051025" ; oboInOwl:hasExactSynonym "down regulation of immunoglobulin production", "down-regulation of immunoglobulin production", "downregulation of immunoglobulin production" ; oboInOwl:hasNarrowSynonym "inhibition of immunoglobulin production", "negative regulation of immunoglobulin biosynthetic process", "negative regulation of immunoglobulin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002638" ; a owl:Class ; rdfs:label "negative regulation of immunoglobulin production" ; rdfs:subClassOf obo:GO_0002637, obo:GO_0002701, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002377 ] ) ] . obo:GO_0002639 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." ; oboInOwl:hasAlternativeId "GO:0002642", "GO:0051024" ; oboInOwl:hasExactSynonym "up regulation of immunoglobulin production", "up-regulation of immunoglobulin production", "upregulation of immunoglobulin production" ; oboInOwl:hasNarrowSynonym "activation of immunoglobulin production", "positive regulation of immunoglobulin biosynthetic process", "positive regulation of immunoglobulin secretion", "stimulation of immunoglobulin production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002639" ; a owl:Class ; rdfs:label "positive regulation of immunoglobulin production" ; rdfs:subClassOf obo:GO_0002637, obo:GO_0002702, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002377 ] ) ] . obo:GO_0002643 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of tolerance induction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002643" ; a owl:Class ; rdfs:label "regulation of tolerance induction" ; rdfs:subClassOf obo:GO_0002682, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002507 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002507 ] ) ] . obo:GO_0002644 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." ; oboInOwl:hasExactSynonym "down regulation of tolerance induction", "down-regulation of tolerance induction", "downregulation of tolerance induction" ; oboInOwl:hasNarrowSynonym "inhibition of tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002644" ; a owl:Class ; rdfs:label "negative regulation of tolerance induction" ; rdfs:subClassOf obo:GO_0002643, obo:GO_0002683, obo:GO_0051093, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002507 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002507 ] ) ] . obo:GO_0002645 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of tolerance induction." ; oboInOwl:hasExactSynonym "up regulation of tolerance induction", "up-regulation of tolerance induction", "upregulation of tolerance induction" ; oboInOwl:hasNarrowSynonym "activation of tolerance induction", "stimulation of tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002645" ; a owl:Class ; rdfs:label "positive regulation of tolerance induction" ; rdfs:subClassOf obo:GO_0002643, obo:GO_0002684, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002507 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002507 ] ) ] . obo:GO_0002652 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." ; oboInOwl:hasExactSynonym "regulation of immune response-dependent tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002652" ; a owl:Class ; rdfs:label "regulation of tolerance induction dependent upon immune response" ; rdfs:subClassOf obo:GO_0002643, obo:GO_0002822, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002461 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002461 ] ) ] . obo:GO_0002653 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." ; oboInOwl:hasExactSynonym "down regulation of tolerance induction dependent upon immune response", "down-regulation of tolerance induction dependent upon immune response", "downregulation of tolerance induction dependent upon immune response", "negative regulation of immune response-dependent tolerance induction" ; oboInOwl:hasNarrowSynonym "inhibition of tolerance induction dependent upon immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002653" ; a owl:Class ; rdfs:label "negative regulation of tolerance induction dependent upon immune response" ; rdfs:subClassOf obo:GO_0002644, obo:GO_0002652, obo:GO_0002823, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002461 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002461 ] ) ] . obo:GO_0002654 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." ; oboInOwl:hasExactSynonym "positive regulation of immune response-dependent tolerance induction", "up regulation of tolerance induction dependent upon immune response", "up-regulation of tolerance induction dependent upon immune response", "upregulation of tolerance induction dependent upon immune response" ; oboInOwl:hasNarrowSynonym "activation of tolerance induction dependent upon immune response", "stimulation of tolerance induction dependent upon immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002654" ; a owl:Class ; rdfs:label "positive regulation of tolerance induction dependent upon immune response" ; rdfs:subClassOf obo:GO_0002645, obo:GO_0002652, obo:GO_0002824, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002461 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002461 ] ) ] . obo:GO_0002658 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002658" ; a owl:Class ; rdfs:label "regulation of peripheral tolerance induction" ; rdfs:subClassOf obo:GO_0002652, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002465 ] ) ] . obo:GO_0002659 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." ; oboInOwl:hasExactSynonym "down regulation of peripheral tolerance induction", "down-regulation of peripheral tolerance induction", "downregulation of peripheral tolerance induction" ; oboInOwl:hasNarrowSynonym "inhibition of peripheral tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002659" ; a owl:Class ; rdfs:label "negative regulation of peripheral tolerance induction" ; rdfs:subClassOf obo:GO_0002653, obo:GO_0002658, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002465 ] ) ] . obo:GO_0002660 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." ; oboInOwl:hasExactSynonym "up regulation of peripheral tolerance induction", "up-regulation of peripheral tolerance induction", "upregulation of peripheral tolerance induction" ; oboInOwl:hasNarrowSynonym "activation of peripheral tolerance induction", "stimulation of peripheral tolerance induction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002660" ; a owl:Class ; rdfs:label "positive regulation of peripheral tolerance induction" ; rdfs:subClassOf obo:GO_0002654, obo:GO_0002658, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002465 ] ) ] . obo:GO_0002673 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002673" ; a owl:Class ; rdfs:label "regulation of acute inflammatory response" ; rdfs:subClassOf obo:GO_0050727, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002526 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002526 ] ) ] . obo:GO_0002674 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." ; oboInOwl:hasExactSynonym "down regulation of acute inflammatory response", "down-regulation of acute inflammatory response", "downregulation of acute inflammatory response" ; oboInOwl:hasNarrowSynonym "inhibition of acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002674" ; a owl:Class ; rdfs:label "negative regulation of acute inflammatory response" ; rdfs:subClassOf obo:GO_0002673, obo:GO_0050728, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002526 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002526 ] ) ] . obo:GO_0002675 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." ; oboInOwl:hasExactSynonym "up regulation of acute inflammatory response", "up-regulation of acute inflammatory response", "upregulation of acute inflammatory response" ; oboInOwl:hasNarrowSynonym "activation of acute inflammatory response", "stimulation of acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002675" ; a owl:Class ; rdfs:label "positive regulation of acute inflammatory response" ; rdfs:subClassOf obo:GO_0002673, obo:GO_0050729, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002526 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002526 ] ) ] . obo:GO_0002676 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002676" ; a owl:Class ; rdfs:label "regulation of chronic inflammatory response" ; rdfs:subClassOf obo:GO_0050727, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002544 ] ) ] . obo:GO_0002677 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." ; oboInOwl:hasExactSynonym "down regulation of chronic inflammatory response", "down-regulation of chronic inflammatory response", "downregulation of chronic inflammatory response" ; oboInOwl:hasNarrowSynonym "inhibition of chronic inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002677" ; a owl:Class ; rdfs:label "negative regulation of chronic inflammatory response" ; rdfs:subClassOf obo:GO_0002676, obo:GO_0050728, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002544 ] ) ] . obo:GO_0002678 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." ; oboInOwl:hasExactSynonym "up regulation of chronic inflammatory response", "up-regulation of chronic inflammatory response", "upregulation of chronic inflammatory response" ; oboInOwl:hasNarrowSynonym "activation of chronic inflammatory response", "stimulation of chronic inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002678" ; a owl:Class ; rdfs:label "positive regulation of chronic inflammatory response" ; rdfs:subClassOf obo:GO_0002676, obo:GO_0050729, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002544 ] ) ] . obo:GO_0002679 obo:IAO_0000115 "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002679" ; a owl:Class ; rdfs:label "respiratory burst involved in defense response" ; rdfs:subClassOf obo:GO_0002252, obo:GO_0045730, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006952 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045730 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006952 ] ) ] . obo:GO_0002682 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an immune system process." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002682" ; a owl:Class ; rdfs:label "regulation of immune system process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002376 ] ) ] . obo:GO_0002683 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." ; oboInOwl:hasExactSynonym "down regulation of immune system process", "down-regulation of immune system process", "downregulation of immune system process" ; oboInOwl:hasNarrowSynonym "inhibition of immune system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002683" ; a owl:Class ; rdfs:label "negative regulation of immune system process" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002376 ] ) ] . obo:GO_0002684 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an immune system process." ; oboInOwl:hasExactSynonym "up regulation of immune system process", "up-regulation of immune system process", "upregulation of immune system process" ; oboInOwl:hasNarrowSynonym "activation of immune system process", "stimulation of immune system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002684" ; a owl:Class ; rdfs:label "positive regulation of immune system process" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002376 ] ) ] . obo:GO_0002685 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of leukocyte migration." ; oboInOwl:hasExactSynonym "regulation of immune cell migration", "regulation of leucocyte migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002685" ; a owl:Class ; rdfs:label "regulation of leukocyte migration" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0030334, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050900 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050900 ] ) ] . obo:GO_0002686 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." ; oboInOwl:hasExactSynonym "down regulation of leukocyte migration", "down-regulation of leukocyte migration", "downregulation of leukocyte migration", "negative regulation of immune cell migration", "negative regulation of leucocyte migration" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002686" ; a owl:Class ; rdfs:label "negative regulation of leukocyte migration" ; rdfs:subClassOf obo:GO_0002683, obo:GO_0002685, obo:GO_0030336, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050900 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050900 ] ) ] . obo:GO_0002687 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." ; oboInOwl:hasExactSynonym "positive regulation of immune cell migration", "positive regulation of leucocyte migration", "up regulation of leukocyte migration", "up-regulation of leukocyte migration", "upregulation of leukocyte migration" ; oboInOwl:hasNarrowSynonym "activation of leukocyte migration", "stimulation of leukocyte migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002687" ; a owl:Class ; rdfs:label "positive regulation of leukocyte migration" ; rdfs:subClassOf obo:GO_0002684, obo:GO_0002685, obo:GO_0030335, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050900 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050900 ] ) ] . obo:GO_0002688 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." ; oboInOwl:hasExactSynonym "regulation of immune cell chemotaxis", "regulation of leucocyte chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002688" ; a owl:Class ; rdfs:label "regulation of leukocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002685, obo:GO_0050920, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030595 ] ) ] . obo:GO_0002689 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." ; oboInOwl:hasExactSynonym "down regulation of leukocyte chemotaxis", "down-regulation of leukocyte chemotaxis", "downregulation of leukocyte chemotaxis", "negative regulation of immune cell chemotaxis", "negative regulation of leucocyte chemotaxis" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002689" ; a owl:Class ; rdfs:label "negative regulation of leukocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002686, obo:GO_0002688, obo:GO_0050922, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030595 ] ) ] . obo:GO_0002690 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." ; oboInOwl:hasExactSynonym "positive regulation of immune cell chemotaxis", "positive regulation of leucocyte chemotaxis", "up regulation of leukocyte chemotaxis", "up-regulation of leukocyte chemotaxis", "upregulation of leukocyte chemotaxis" ; oboInOwl:hasNarrowSynonym "activation of leukocyte chemotaxis", "stimulation of leukocyte chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002690" ; a owl:Class ; rdfs:label "positive regulation of leukocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002687, obo:GO_0002688, obo:GO_0050921, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030595 ] ) ] . obo:GO_0002694 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of leukocyte activation." ; oboInOwl:hasExactSynonym "regulation of immune cell activation", "regulation of leucocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002694" ; a owl:Class ; rdfs:label "regulation of leukocyte activation" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0050865, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045321 ] ) ] . obo:GO_0002695 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." ; oboInOwl:hasExactSynonym "down regulation of leukocyte activation", "down-regulation of leukocyte activation", "downregulation of leukocyte activation", "negative regulation of immune cell activation", "negative regulation of leucocyte activation" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002695" ; a owl:Class ; rdfs:label "negative regulation of leukocyte activation" ; rdfs:subClassOf obo:GO_0002683, obo:GO_0002694, obo:GO_0050866, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045321 ] ) ] . obo:GO_0002696 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." ; oboInOwl:hasExactSynonym "positive regulation of immune cell activation", "positive regulation of leucocyte activation", "up regulation of leukocyte activation", "up-regulation of leukocyte activation", "upregulation of leukocyte activation" ; oboInOwl:hasNarrowSynonym "activation of leukocyte activation", "stimulation of leukocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002696" ; a owl:Class ; rdfs:label "positive regulation of leukocyte activation" ; rdfs:subClassOf obo:GO_0002684, obo:GO_0002694, obo:GO_0050867, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045321 ] ) ] . obo:GO_0002697 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an immune effector process." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002697" ; a owl:Class ; rdfs:label "regulation of immune effector process" ; rdfs:subClassOf obo:GO_0002682, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002252 ] ) ] . obo:GO_0002698 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." ; oboInOwl:hasExactSynonym "down regulation of immune effector process", "down-regulation of immune effector process", "downregulation of immune effector process" ; oboInOwl:hasNarrowSynonym "inhibition of immune effector process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002698" ; a owl:Class ; rdfs:label "negative regulation of immune effector process" ; rdfs:subClassOf obo:GO_0002683, obo:GO_0002697, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002252 ] ) ] . obo:GO_0002699 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an immune effector process." ; oboInOwl:hasExactSynonym "up regulation of immune effector process", "up-regulation of immune effector process", "upregulation of immune effector process" ; oboInOwl:hasNarrowSynonym "activation of immune effector process", "stimulation of immune effector process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002699" ; a owl:Class ; rdfs:label "positive regulation of immune effector process" ; rdfs:subClassOf obo:GO_0002684, obo:GO_0002697, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002252 ] ) ] . obo:GO_0002700 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002700" ; a owl:Class ; rdfs:label "regulation of production of molecular mediator of immune response" ; rdfs:subClassOf obo:GO_0002697, obo:GO_0010468, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002440 ] ) ] . obo:GO_0002701 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." ; oboInOwl:hasExactSynonym "down regulation of production of molecular mediator of immune response", "down-regulation of production of molecular mediator of immune response", "downregulation of production of molecular mediator of immune response" ; oboInOwl:hasNarrowSynonym "inhibition of production of molecular mediator of immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002701" ; a owl:Class ; rdfs:label "negative regulation of production of molecular mediator of immune response" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0002700, obo:GO_0010629, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002440 ] ) ] . obo:GO_0002702 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." ; oboInOwl:hasExactSynonym "up regulation of production of molecular mediator of immune response", "up-regulation of production of molecular mediator of immune response", "upregulation of production of molecular mediator of immune response" ; oboInOwl:hasNarrowSynonym "activation of production of molecular mediator of immune response", "stimulation of production of molecular mediator of immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002702" ; a owl:Class ; rdfs:label "positive regulation of production of molecular mediator of immune response" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0002700, obo:GO_0010628, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002440 ] ) ] . obo:GO_0002703 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." ; oboInOwl:hasExactSynonym "regulation of immune cell mediated immunity", "regulation of leucocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002703" ; a owl:Class ; rdfs:label "regulation of leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002697, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002443 ] ) ] . obo:GO_0002704 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." ; oboInOwl:hasExactSynonym "down regulation of leukocyte mediated immunity", "down-regulation of leukocyte mediated immunity", "downregulation of leukocyte mediated immunity", "negative regulation of immune cell mediated immunity", "negative regulation of leucocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002704" ; a owl:Class ; rdfs:label "negative regulation of leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0002703, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002443 ] ) ] . obo:GO_0002705 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." ; oboInOwl:hasExactSynonym "positive regulation of immune cell mediated immunity", "positive regulation of leucocyte mediated immunity", "up regulation of leukocyte mediated immunity", "up-regulation of leukocyte mediated immunity", "upregulation of leukocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of leukocyte mediated immunity", "stimulation of leukocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002705" ; a owl:Class ; rdfs:label "positive regulation of leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0002703, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002443 ] ) ] . obo:GO_0002706 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002706" ; a owl:Class ; rdfs:label "regulation of lymphocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002703, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002449 ] ) ] . obo:GO_0002707 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." ; oboInOwl:hasExactSynonym "down regulation of lymphocyte mediated immunity", "down-regulation of lymphocyte mediated immunity", "downregulation of lymphocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002707" ; a owl:Class ; rdfs:label "negative regulation of lymphocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002704, obo:GO_0002706, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002449 ] ) ] . obo:GO_0002708 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." ; oboInOwl:hasExactSynonym "up regulation of lymphocyte mediated immunity", "up-regulation of lymphocyte mediated immunity", "upregulation of lymphocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of lymphocyte mediated immunity", "stimulation of lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002708" ; a owl:Class ; rdfs:label "positive regulation of lymphocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002705, obo:GO_0002706, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002449 ] ) ] . obo:GO_0002709 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." ; oboInOwl:hasExactSynonym "regulation of T lymphocyte mediated immunity", "regulation of T-cell mediated immunity", "regulation of T-lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002709" ; a owl:Class ; rdfs:label "regulation of T cell mediated immunity" ; rdfs:subClassOf obo:GO_0002706, obo:GO_0002822, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002456 ] ) ] . obo:GO_0002710 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." ; oboInOwl:hasExactSynonym "down regulation of T cell mediated immunity", "down-regulation of T cell mediated immunity", "downregulation of T cell mediated immunity", "negative regulation of T lymphocyte mediated immunity", "negative regulation of T-cell mediated immunity", "negative regulation of T-lymphocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of T cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002710" ; a owl:Class ; rdfs:label "negative regulation of T cell mediated immunity" ; rdfs:subClassOf obo:GO_0002707, obo:GO_0002709, obo:GO_0002823, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002456 ] ) ] . obo:GO_0002711 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." ; oboInOwl:hasExactSynonym "positive regulation of T lymphocyte mediated immunity", "positive regulation of T-cell mediated immunity", "positive regulation of T-lymphocyte mediated immunity", "up regulation of T cell mediated immunity", "up-regulation of T cell mediated immunity", "upregulation of T cell mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of T cell mediated immunity", "stimulation of T cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002711" ; a owl:Class ; rdfs:label "positive regulation of T cell mediated immunity" ; rdfs:subClassOf obo:GO_0002708, obo:GO_0002709, obo:GO_0002824, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002456 ] ) ] . obo:GO_0002712 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." ; oboInOwl:hasExactSynonym "regulation of B lymphocyte mediated immunity", "regulation of B-cell mediated immunity", "regulation of B-lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002712" ; a owl:Class ; rdfs:label "regulation of B cell mediated immunity" ; rdfs:subClassOf obo:GO_0002706, obo:GO_0002822, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019724 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:GO_0002713 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." ; oboInOwl:hasExactSynonym "down regulation of B cell mediated immunity", "down-regulation of B cell mediated immunity", "downregulation of B cell mediated immunity", "negative regulation of B lymphocyte mediated immunity", "negative regulation of B-cell mediated immunity", "negative regulation of B-lymphocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of B cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002713" ; a owl:Class ; rdfs:label "negative regulation of B cell mediated immunity" ; rdfs:subClassOf obo:GO_0002707, obo:GO_0002712, obo:GO_0002823, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019724 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:GO_0002714 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." ; oboInOwl:hasExactSynonym "positive regulation of B lymphocyte mediated immunity", "positive regulation of B-cell mediated immunity", "positive regulation of B-lymphocyte mediated immunity", "up regulation of B cell mediated immunity", "up-regulation of B cell mediated immunity", "upregulation of B cell mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of B cell mediated immunity", "stimulation of B cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002714" ; a owl:Class ; rdfs:label "positive regulation of B cell mediated immunity" ; rdfs:subClassOf obo:GO_0002708, obo:GO_0002712, obo:GO_0002824, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019724 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019724 ] ) ] . obo:GO_0002715 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." ; oboInOwl:hasAlternativeId "GO:0045845" ; oboInOwl:hasExactSynonym "regulation of NK cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of natural killer cell activity" ; oboInOwl:id "GO:0002715" ; a owl:Class ; rdfs:label "regulation of natural killer cell mediated immunity" ; rdfs:subClassOf obo:GO_0002706, obo:GO_0045088, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002228 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002228 ] ) ] . obo:GO_0002716 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." ; oboInOwl:hasAlternativeId "GO:0030102" ; oboInOwl:hasExactSynonym "down regulation of natural killer cell mediated immunity", "down-regulation of natural killer cell mediated immunity", "downregulation of natural killer cell mediated immunity", "negative regulation of NK cell mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of natural killer cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of NK cell activity", "negative regulation of natural killer cell activity" ; oboInOwl:id "GO:0002716" ; a owl:Class ; rdfs:label "negative regulation of natural killer cell mediated immunity" ; rdfs:subClassOf obo:GO_0002707, obo:GO_0002715, obo:GO_0045824, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002228 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002228 ] ) ] . obo:GO_0002717 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." ; oboInOwl:hasAlternativeId "GO:0045846" ; oboInOwl:hasExactSynonym "positive regulation of NK cell mediated immunity", "up regulation of natural killer cell mediated immunity", "up-regulation of natural killer cell mediated immunity", "upregulation of natural killer cell mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of natural killer cell mediated immunity", "stimulation of natural killer cell mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of NK cell activity", "positive regulation of natural killer cell activity" ; oboInOwl:id "GO:0002717" ; a owl:Class ; rdfs:label "positive regulation of natural killer cell mediated immunity" ; rdfs:subClassOf obo:GO_0002708, obo:GO_0002715, obo:GO_0045089, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002228 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002228 ] ) ] . obo:GO_0002718 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." ; oboInOwl:hasAlternativeId "GO:0002739", "GO:0002742" ; oboInOwl:hasNarrowSynonym "regulation of cytokine biosynthetic process involved in immune response", "regulation of cytokine secretion involved in immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cytokine production during immune response" ; oboInOwl:id "GO:0002718" ; a owl:Class ; rdfs:label "regulation of cytokine production involved in immune response" ; rdfs:subClassOf obo:GO_0001817, obo:GO_0002700, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002367 ] ) ] . obo:GO_0002719 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." ; oboInOwl:hasAlternativeId "GO:0002740", "GO:0002743" ; oboInOwl:hasExactSynonym "down-regulation of cytokine production during immune response" ; oboInOwl:hasNarrowSynonym "negative regulation of cytokine biosynthetic process involved in immune response", "negative regulation of cytokine secretion involved in immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of cytokine production during immune response", "downregulation of cytokine production during immune response", "inhibition of cytokine production during immune response", "negative regulation of cytokine production during immune response" ; oboInOwl:id "GO:0002719" ; a owl:Class ; rdfs:label "negative regulation of cytokine production involved in immune response" ; rdfs:subClassOf obo:GO_0001818, obo:GO_0002701, obo:GO_0002718, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002367 ] ) ] . obo:GO_0002720 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." ; oboInOwl:hasAlternativeId "GO:0002741", "GO:0002744" ; oboInOwl:hasNarrowSynonym "activation of cytokine production during immune response", "positive regulation of cytokine biosynthetic process involved in immune response", "positive regulation of cytokine secretion involved in immune response", "stimulation of cytokine production during immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cytokine production during immune response", "up regulation of cytokine production during immune response", "up-regulation of cytokine production during immune response", "upregulation of cytokine production during immune response" ; oboInOwl:id "GO:0002720" ; a owl:Class ; rdfs:label "positive regulation of cytokine production involved in immune response" ; rdfs:subClassOf obo:GO_0001819, obo:GO_0002702, obo:GO_0002718, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002367 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002367 ] ) ] . obo:GO_0002759 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002759" ; a owl:Class ; rdfs:label "regulation of antimicrobial humoral response" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0002920, obo:GO_0031347, obo:GO_0032101, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019730 ] ) ] . obo:GO_0002760 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." ; oboInOwl:hasExactSynonym "up regulation of antimicrobial humoral response", "up-regulation of antimicrobial humoral response", "upregulation of antimicrobial humoral response" ; oboInOwl:hasNarrowSynonym "activation of antimicrobial humoral response", "stimulation of antimicrobial humoral response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002760" ; a owl:Class ; rdfs:label "positive regulation of antimicrobial humoral response" ; rdfs:subClassOf obo:GO_0002759, obo:GO_0002833, obo:GO_0002922, obo:GO_0031349, obo:GO_0032103, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019730 ] ) ] . obo:GO_0002761 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002761" ; a owl:Class ; rdfs:label "regulation of myeloid leukocyte differentiation" ; rdfs:subClassOf obo:GO_0045637, obo:GO_1902105, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002573 ] ) ] . obo:GO_0002762 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of myeloid leukocyte differentiation", "down-regulation of myeloid leukocyte differentiation", "downregulation of myeloid leukocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of myeloid leukocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002762" ; a owl:Class ; rdfs:label "negative regulation of myeloid leukocyte differentiation" ; rdfs:subClassOf obo:GO_0002761, obo:GO_0045638, obo:GO_1902106, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002573 ] ) ] . obo:GO_0002763 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of myeloid leukocyte differentiation", "up-regulation of myeloid leukocyte differentiation", "upregulation of myeloid leukocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of myeloid leukocyte differentiation", "stimulation of myeloid leukocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002763" ; a owl:Class ; rdfs:label "positive regulation of myeloid leukocyte differentiation" ; rdfs:subClassOf obo:GO_0002761, obo:GO_0045639, obo:GO_1902107, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002573 ] ) ] . obo:GO_0002775 obo:IAO_0000115 "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002775" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ; rdfs:label "antimicrobial peptide production" ; rdfs:subClassOf obo:GO_0002440, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0061844 ] . obo:GO_0002776 obo:IAO_0000115 "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002776" ; a owl:Class ; rdfs:label "antimicrobial peptide secretion" ; rdfs:subClassOf obo:GO_0002790, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002775 ] . obo:GO_0002784 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002784" ; a owl:Class ; rdfs:label "regulation of antimicrobial peptide production" ; rdfs:subClassOf obo:GO_0002700, obo:GO_0002759, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002775 ] ) ] . obo:GO_0002785 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." ; oboInOwl:hasExactSynonym "down regulation of antimicrobial peptide production", "down-regulation of antimicrobial peptide production", "downregulation of antimicrobial peptide production" ; oboInOwl:hasNarrowSynonym "inhibition of antimicrobial peptide production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002785" ; a owl:Class ; rdfs:label "negative regulation of antimicrobial peptide production" ; rdfs:subClassOf obo:GO_0002701, obo:GO_0002784, obo:GO_0008348, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002775 ] ) ] . obo:GO_0002790 obo:IAO_0000115 "The controlled release of a peptide from a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002790" ; a owl:Class ; rdfs:label "peptide secretion" ; rdfs:subClassOf obo:GO_0015833, obo:GO_0046903 . obo:GO_0002791 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of peptide secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002791" ; a owl:Class ; rdfs:label "regulation of peptide secretion" ; rdfs:subClassOf obo:GO_0051046, obo:GO_0090087, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002790 ] ) ] . obo:GO_0002792 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." ; oboInOwl:hasExactSynonym "down regulation of peptide secretion", "down-regulation of peptide secretion", "downregulation of peptide secretion" ; oboInOwl:hasNarrowSynonym "inhibition of peptide secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002792" ; a owl:Class ; rdfs:label "negative regulation of peptide secretion" ; rdfs:subClassOf obo:GO_0002791, obo:GO_0051048, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002790 ] ) ] . obo:GO_0002793 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of peptide secretion." ; oboInOwl:hasExactSynonym "up regulation of peptide secretion", "up-regulation of peptide secretion", "upregulation of peptide secretion" ; oboInOwl:hasNarrowSynonym "activation of peptide secretion", "stimulation of peptide secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002793" ; a owl:Class ; rdfs:label "positive regulation of peptide secretion" ; rdfs:subClassOf obo:GO_0002791, obo:GO_0051047, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002790 ] ) ] . obo:GO_0002794 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002794" ; a owl:Class ; rdfs:label "regulation of antimicrobial peptide secretion" ; rdfs:subClassOf obo:GO_0002784, obo:GO_0002791, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002776 ] ) ] . obo:GO_0002795 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." ; oboInOwl:hasExactSynonym "down regulation of antimicrobial peptide secretion", "down-regulation of antimicrobial peptide secretion", "downregulation of antimicrobial peptide secretion" ; oboInOwl:hasNarrowSynonym "inhibition of antimicrobial peptide secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002795" ; a owl:Class ; rdfs:label "negative regulation of antimicrobial peptide secretion" ; rdfs:subClassOf obo:GO_0002785, obo:GO_0002792, obo:GO_0002794, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002776 ] ) ] . obo:GO_0002796 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." ; oboInOwl:hasExactSynonym "up regulation of antimicrobial peptide secretion", "up-regulation of antimicrobial peptide secretion", "upregulation of antimicrobial peptide secretion" ; oboInOwl:hasNarrowSynonym "activation of antimicrobial peptide secretion", "stimulation of antimicrobial peptide secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002796" ; a owl:Class ; rdfs:label "positive regulation of antimicrobial peptide secretion" ; rdfs:subClassOf obo:GO_0002225, obo:GO_0002793, obo:GO_0002794, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002776 ] ) ] . obo:GO_0002819 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an adaptive immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002819" ; a owl:Class ; rdfs:label "regulation of adaptive immune response" ; rdfs:subClassOf obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002250 ] ) ] . obo:GO_0002820 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." ; oboInOwl:hasExactSynonym "down regulation of adaptive immune response", "down-regulation of adaptive immune response", "downregulation of adaptive immune response" ; oboInOwl:hasNarrowSynonym "inhibition of adaptive immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002820" ; a owl:Class ; rdfs:label "negative regulation of adaptive immune response" ; rdfs:subClassOf obo:GO_0002819, obo:GO_0050777, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002250 ] ) ] . obo:GO_0002821 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." ; oboInOwl:hasExactSynonym "up regulation of adaptive immune response", "up-regulation of adaptive immune response", "upregulation of adaptive immune response" ; oboInOwl:hasNarrowSynonym "activation of adaptive immune response", "stimulation of adaptive immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002821" ; a owl:Class ; rdfs:label "positive regulation of adaptive immune response" ; rdfs:subClassOf obo:GO_0002819, obo:GO_0050778, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002250 ] ) ] . obo:GO_0002822 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002822" ; a owl:Class ; rdfs:label "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" ; rdfs:subClassOf obo:GO_0002819, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002460 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002460 ] ) ] . obo:GO_0002823 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002823" ; a owl:Class ; rdfs:label "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" ; rdfs:subClassOf obo:GO_0002820, obo:GO_0002822, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002460 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002460 ] ) ] . obo:GO_0002824 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002824" ; a owl:Class ; rdfs:label "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" ; rdfs:subClassOf obo:GO_0002821, obo:GO_0002822, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002460 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002460 ] ) ] . obo:GO_0002828 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of a type 2 immune response." ; oboInOwl:hasNarrowSynonym "regulation of T-helper 2 type immune response", "regulation of Th2 immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002828" ; a owl:Class ; rdfs:label "regulation of type 2 immune response" ; rdfs:subClassOf obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042092 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042092 ] ) ] . obo:GO_0002829 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." ; oboInOwl:hasExactSynonym "down regulation of type 2 immune response", "down-regulation of type 2 immune response", "downregulation of type 2 immune response" ; oboInOwl:hasNarrowSynonym "inhibition of type 2 immune response", "negative regulation of T-helper 2 type immune response", "negative regulation of Th2 immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002829" ; a owl:Class ; rdfs:label "negative regulation of type 2 immune response" ; rdfs:subClassOf obo:GO_0002828, obo:GO_0050777, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042092 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042092 ] ) ] . obo:GO_0002830 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." ; oboInOwl:hasExactSynonym "up regulation of type 2 immune response", "up-regulation of type 2 immune response", "upregulation of type 2 immune response" ; oboInOwl:hasNarrowSynonym "activation of type 2 immune response", "positive regulation of T-helper 2 type immune response", "positive regulation of Th2 immune response", "stimulation of type 2 immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002830" ; a owl:Class ; rdfs:label "positive regulation of type 2 immune response" ; rdfs:subClassOf obo:GO_0002828, obo:GO_0050778, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042092 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042092 ] ) ] . obo:GO_0002831 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002831" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "regulation of response to biotic stimulus" ; rdfs:subClassOf obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009607 ] ) ] . obo:GO_0002832 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." ; oboInOwl:hasExactSynonym "down regulation of response to biotic stimulus", "down-regulation of response to biotic stimulus", "downregulation of response to biotic stimulus" ; oboInOwl:hasNarrowSynonym "inhibition of response to biotic stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002832" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "negative regulation of response to biotic stimulus" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0048585, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009607 ] ) ] . obo:GO_0002833 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." ; oboInOwl:hasExactSynonym "up regulation of response to biotic stimulus", "up-regulation of response to biotic stimulus", "upregulation of response to biotic stimulus" ; oboInOwl:hasNarrowSynonym "activation of response to biotic stimulus", "stimulation of response to biotic stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002833" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "positive regulation of response to biotic stimulus" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0048584, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009607 ] ) ] . obo:GO_0002886 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002886" ; a owl:Class ; rdfs:label "regulation of myeloid leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002703, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002444 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002444 ] ) ] . obo:GO_0002887 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." ; oboInOwl:hasExactSynonym "down regulation of myeloid leukocyte mediated immunity", "down-regulation of myeloid leukocyte mediated immunity", "downregulation of myeloid leukocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "inhibition of myeloid leukocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002887" ; a owl:Class ; rdfs:label "negative regulation of myeloid leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002704, obo:GO_0002886, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002444 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002444 ] ) ] . obo:GO_0002888 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." ; oboInOwl:hasExactSynonym "up regulation of myeloid leukocyte mediated immunity", "up-regulation of myeloid leukocyte mediated immunity", "upregulation of myeloid leukocyte mediated immunity" ; oboInOwl:hasNarrowSynonym "activation of myeloid leukocyte mediated immunity", "stimulation of myeloid leukocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002888" ; a owl:Class ; rdfs:label "positive regulation of myeloid leukocyte mediated immunity" ; rdfs:subClassOf obo:GO_0002705, obo:GO_0002886, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002444 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002444 ] ) ] . obo:GO_0002889 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002889" ; a owl:Class ; rdfs:label "regulation of immunoglobulin mediated immune response" ; rdfs:subClassOf obo:GO_0002712, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016064 ] ) ] . obo:GO_0002890 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." ; oboInOwl:hasExactSynonym "down regulation of immunoglobulin mediated immune response", "down-regulation of immunoglobulin mediated immune response", "downregulation of immunoglobulin mediated immune response" ; oboInOwl:hasNarrowSynonym "inhibition of immunoglobulin mediated immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002890" ; a owl:Class ; rdfs:label "negative regulation of immunoglobulin mediated immune response" ; rdfs:subClassOf obo:GO_0002713, obo:GO_0002889, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016064 ] ) ] . obo:GO_0002891 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." ; oboInOwl:hasExactSynonym "up regulation of immunoglobulin mediated immune response", "up-regulation of immunoglobulin mediated immune response", "upregulation of immunoglobulin mediated immune response" ; oboInOwl:hasNarrowSynonym "activation of immunoglobulin mediated immune response", "stimulation of immunoglobulin mediated immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002891" ; a owl:Class ; rdfs:label "positive regulation of immunoglobulin mediated immune response" ; rdfs:subClassOf obo:GO_0002714, obo:GO_0002889, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016064 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016064 ] ) ] . obo:GO_0002920 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of a humoral immune response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002920" ; a owl:Class ; rdfs:label "regulation of humoral immune response" ; rdfs:subClassOf obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006959 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006959 ] ) ] . obo:GO_0002921 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." ; oboInOwl:hasExactSynonym "down regulation of humoral immune response", "down-regulation of humoral immune response", "downregulation of humoral immune response" ; oboInOwl:hasNarrowSynonym "inhibition of humoral immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002921" ; a owl:Class ; rdfs:label "negative regulation of humoral immune response" ; rdfs:subClassOf obo:GO_0002920, obo:GO_0050777, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006959 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006959 ] ) ] . obo:GO_0002922 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." ; oboInOwl:hasExactSynonym "up regulation of humoral immune response", "up-regulation of humoral immune response", "upregulation of humoral immune response" ; oboInOwl:hasNarrowSynonym "activation of humoral immune response", "stimulation of humoral immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0002922" ; a owl:Class ; rdfs:label "positive regulation of humoral immune response" ; rdfs:subClassOf obo:GO_0002920, obo:GO_0050778, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006959 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006959 ] ) ] . obo:GO_0003002 obo:IAO_0000115 "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pattern formation" ; oboInOwl:id "GO:0003002" ; a owl:Class ; rdfs:label "regionalization" ; rdfs:subClassOf obo:GO_0007389 . obo:GO_0003006 obo:IAO_0000115 "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." ; oboInOwl:hasNarrowSynonym "puberty" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "reproductive developmental process" ; oboInOwl:id "GO:0003006" ; a owl:Class ; rdfs:label "developmental process involved in reproduction" ; rdfs:subClassOf obo:GO_0022414, obo:GO_0032502 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000003 ] ) ] . obo:GO_0003008 obo:IAO_0000115 "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." ; oboInOwl:hasExactSynonym "organ system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003008" ; a owl:Class ; rdfs:label "system process" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0003009 obo:IAO_0000115 "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003009" ; a owl:Class ; rdfs:label "skeletal muscle contraction" ; rdfs:subClassOf obo:GO_0006941, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050881 ] . obo:GO_0003010 obo:IAO_0000115 "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003010" ; a owl:Class ; rdfs:label "voluntary skeletal muscle contraction" ; rdfs:subClassOf obo:GO_0003009 . obo:GO_0003012 obo:IAO_0000115 "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "muscle physiological process" ; oboInOwl:id "GO:0003012" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic ; a owl:Class ; rdfs:label "muscle system process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0003013 obo:IAO_0000115 "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." ; oboInOwl:hasDbXref "Wikipedia:Circulatory_system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003013" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic ; a owl:Class ; rdfs:label "circulatory system process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0003014 obo:IAO_0000115 "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." ; oboInOwl:hasExactSynonym "excretory system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "kidney system process" ; oboInOwl:id "GO:0003014" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "renal system process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0003015 obo:IAO_0000115 "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cardiac process" ; oboInOwl:id "GO:0003015" ; a owl:Class ; rdfs:label "heart process" ; rdfs:subClassOf obo:GO_0003013 . obo:GO_0003016 obo:IAO_0000115 "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." ; oboInOwl:hasAlternativeId "GO:0010802" ; oboInOwl:hasExactSynonym "respiratory gaseous exchange" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003016" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "respiratory system process" ; rdfs:subClassOf obo:GO_0003008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007585 ] . obo:GO_0003044 obo:IAO_0000115 "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." ; oboInOwl:hasExactSynonym "blood pressure regulation mediated by a chemical signal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003044" ; a owl:Class ; rdfs:label "regulation of systemic arterial blood pressure mediated by a chemical signal" ; rdfs:subClassOf obo:GO_0003073 . obo:GO_0003071 obo:IAO_0000115 "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." ; oboInOwl:hasExactSynonym "renal control of blood pressure", "renal regulation of systemic arterial blood pressure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003071" ; a owl:Class ; rdfs:label "renal system process involved in regulation of systemic arterial blood pressure" ; rdfs:subClassOf obo:GO_0003014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0003014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003073 ] ) ] . obo:GO_0003073 obo:IAO_0000115 "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003073" ; a owl:Class ; rdfs:label "regulation of systemic arterial blood pressure" ; rdfs:subClassOf obo:GO_0008217 . obo:GO_0003081 obo:IAO_0000115 "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." ; oboInOwl:hasExactSynonym "blood pressure regulation by renin-angiotensin" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003081" ; a owl:Class ; rdfs:label "regulation of systemic arterial blood pressure by renin-angiotensin" ; rdfs:subClassOf obo:GO_0001990 . obo:GO_0003091 obo:IAO_0000115 "Renal process involved in the maintenance of an internal steady state of water in the body." ; oboInOwl:hasExactSynonym "water homeostasis by the renal system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003091" ; a owl:Class ; rdfs:label "renal water homeostasis" ; rdfs:subClassOf obo:GO_0003014, obo:GO_0050891 . obo:GO_0003093 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003093" ; a owl:Class ; rdfs:label "regulation of glomerular filtration" ; rdfs:subClassOf obo:GO_0001977, obo:GO_0098801, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003094 ] ) ] . obo:GO_0003094 obo:IAO_0000115 "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003094" ; a owl:Class ; rdfs:label "glomerular filtration" ; rdfs:subClassOf obo:GO_0097205 . obo:GO_0003097 obo:IAO_0000115 "The directed movement of water (H2O) by the renal system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003097" ; a owl:Class ; rdfs:label "renal water transport" ; rdfs:subClassOf obo:GO_0003014, obo:GO_0006833, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003091 ] . obo:GO_0003104 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003104" ; a owl:Class ; rdfs:label "positive regulation of glomerular filtration" ; rdfs:subClassOf obo:GO_0003093, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003094 ] ) ] . obo:GO_0003105 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003105" ; a owl:Class ; rdfs:label "negative regulation of glomerular filtration" ; rdfs:subClassOf obo:GO_0003093, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003094 ] ) ] . obo:GO_0003330 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-11-02T02:07:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003330" ; a owl:Class ; rdfs:label "regulation of extracellular matrix constituent secretion" ; rdfs:subClassOf obo:GO_1903053, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070278 ] ) ] . obo:GO_0003331 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-11-02T02:11:22Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003331" ; a owl:Class ; rdfs:label "positive regulation of extracellular matrix constituent secretion" ; rdfs:subClassOf obo:GO_0003330, obo:GO_1903055, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070278 ] ) ] . obo:GO_0003332 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-11-02T02:13:49Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0003332" ; a owl:Class ; rdfs:label "negative regulation of extracellular matrix constituent secretion" ; rdfs:subClassOf obo:GO_0003330, obo:GO_1903054, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070278 ] ) ] . obo:GO_0003341 obo:IAO_0000115 "The directed, self-propelled movement of a cilium." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19809"^^xsd:anyURI ; obo:RO_0002161 obo:NCBITaxon_3176, obo:NCBITaxon_3312, obo:NCBITaxon_3378, obo:NCBITaxon_3398, obo:NCBITaxon_4890, obo:NCBITaxon_5782 ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-11-24T09:56:26Z" ; oboInOwl:hasAlternativeId "GO:0036142" ; oboInOwl:hasExactSynonym "microtubule-based flagellum movement" ; oboInOwl:hasNarrowSynonym "flagellar movement", "flagellum movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ciliary motility", "cilium beating", "flagellar motility" ; oboInOwl:id "GO:0003341" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "cilium movement" ; rdfs:subClassOf obo:GO_0007018 . obo:GO_0003352 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-12-03T10:12:00Z" ; oboInOwl:hasAlternativeId "GO:1900172" ; oboInOwl:hasExactSynonym "regulation of microtubule-based flagellum movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of flagellar movement", "regulation of flagellum movement" ; oboInOwl:id "GO:0003352" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "regulation of cilium movement" ; rdfs:subClassOf obo:GO_0060632, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003341 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003341 ] ) ] . obo:GO_0003353 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-12-03T10:16:10Z" ; oboInOwl:hasAlternativeId "GO:1900174" ; oboInOwl:hasExactSynonym "positive regulation of microtubule-based flagellum movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of flagellar movement", "positive regulation of flagellum movement" ; oboInOwl:id "GO:0003353" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "positive regulation of cilium movement" ; rdfs:subClassOf obo:GO_0003352, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003341 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003341 ] ) ] . obo:GO_0003354 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-12-03T10:17:47Z" ; oboInOwl:hasAlternativeId "GO:1900173" ; oboInOwl:hasExactSynonym "negative regulation of microtubule-based flagellum movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of flagellum movement" ; oboInOwl:id "GO:0003354" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "negative regulation of cilium movement" ; rdfs:subClassOf obo:GO_0003352, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003341 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003341 ] ) ] . obo:GO_0003674 obo:IAO_0000115 "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." ; oboInOwl:hasAlternativeId "GO:0005554" ; oboInOwl:hasExactSynonym "molecular function" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0003674" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex." ; rdfs:label "molecular_function" . obo:GO_0003824 obo:IAO_0000115 "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." ; oboInOwl:hasDbXref "Wikipedia:Enzyme" ; oboInOwl:hasExactSynonym "enzyme activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0003824" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "catalytic activity" ; rdfs:subClassOf obo:GO_0003674 . obo:GO_0003857 obo:IAO_0000115 "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." ; oboInOwl:hasBroadSynonym "beta-ketoacyl-CoA reductase" ; oboInOwl:hasDbXref "EC:1.1.1.35", "MetaCyc:OHACYL-COA-DEHYDROG-RXN", "RHEA:22432", "Reactome:R-HSA-193455", "Reactome:R-HSA-193508", "Reactome:R-HSA-389995", "Reactome:R-HSA-390251", "Reactome:R-HSA-508369", "Reactome:R-HSA-6809264", "Reactome:R-HSA-70837", "Reactome:R-HSA-77254", "Reactome:R-HSA-77283", "Reactome:R-HSA-77303", "Reactome:R-HSA-77312", "Reactome:R-HSA-77323", "Reactome:R-HSA-77331", "Reactome:R-HSA-77342", "UM-BBD_enzymeID:e0664" ; oboInOwl:hasNarrowSynonym "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "3-oxoacyl-thioester reductase activity", "L-3-hydroxyacyl CoA dehydrogenase activity", "L-3-hydroxyacyl coenzyme A dehydrogenase activity", "beta-hydroxyacyl dehydrogenase activity", "beta-hydroxyacyl-coenzyme A synthetase activity", "beta-hydroxyacylcoenzyme A dehydrogenase activity", "beta-keto-reductase activity" ; oboInOwl:id "GO:0003857" ; a owl:Class ; rdfs:comment "See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'." ; rdfs:label "3-hydroxyacyl-CoA dehydrogenase activity" ; rdfs:subClassOf obo:GO_0016616 . obo:GO_0004035 obo:IAO_0000115 "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ; oboInOwl:hasBroadSynonym "glycerophosphatase activity", "phosphomonoesterase activity" ; oboInOwl:hasDbXref "EC:3.1.3.1", "MetaCyc:ALKAPHOSPHA-RXN", "Reactome:R-HSA-8878787" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "alkaline phenyl phosphatase activity", "alkaline phosphohydrolase activity", "alkaline phosphomonoesterase activity", "orthophosphoric-monoester phosphohydrolase (alkaline optimum)", "phosphate-monoester phosphohydrolase (alkaline optimum)" ; oboInOwl:id "GO:0004035" ; a owl:Class ; rdfs:label "alkaline phosphatase activity" ; rdfs:subClassOf obo:GO_0016791 . obo:GO_0004095 obo:IAO_0000115 "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." ; oboInOwl:hasDbXref "EC:2.3.1.21", "MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN", "RHEA:12661", "Reactome:R-HSA-200406", "Reactome:R-HSA-200410" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "CPT", "CPT I (outer membrane carnitine palmitoyl transferase)", "CPT-A", "CPT-B", "CPTi", "CPTo", "L-carnitine palmitoyltransferase activity", "acylcarnitine transferase activity", "carnitine palmitoyltransferase I", "carnitine palmitoyltransferase II", "carnitine palmitoyltransferase activity", "carnitine palmitoyltransferase-A", "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity", "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity", "palmitoylcarnitine transferase activity" ; oboInOwl:id "GO:0004095" ; a owl:Class ; rdfs:label "carnitine O-palmitoyltransferase activity" ; rdfs:subClassOf obo:GO_0016406, obo:GO_0016416 . obo:GO_0004333 obo:IAO_0000115 "Catalysis of the reaction: (S)-malate = fumarate + H2O." ; oboInOwl:hasDbXref "EC:4.2.1.2", "KEGG_REACTION:R01082", "MetaCyc:FUMHYDR-RXN", "RHEA:12460", "Reactome:R-HSA-451033", "Reactome:R-HSA-70982" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "(S)-malate hydro-lyase (fumarate-forming)", "(S)-malate hydro-lyase activity", "L-malate hydro-lyase activity", "fumarase activity" ; oboInOwl:id "GO:0004333" ; a owl:Class ; rdfs:label "fumarate hydratase activity" ; rdfs:subClassOf obo:GO_0016836 . obo:GO_0004494 obo:IAO_0000115 "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." ; oboInOwl:hasDbXref "EC:5.4.99.2", "KEGG_REACTION:R00833", "MetaCyc:METHYLMALONYL-COA-MUT-RXN", "RHEA:22888", "Reactome:R-HSA-3322971", "Reactome:R-HSA-71010", "UM-BBD_reactionID:r0922" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity", "(R)-methylmalonyl-CoA CoA-carbonylmutase activity", "(S)-methylmalonyl-CoA mutase activity", "methylmalonyl coenzyme A carbonylmutase activity", "methylmalonyl coenzyme A mutase activity", "methylmalonyl-CoA CoA-carbonyl mutase activity" ; oboInOwl:id "GO:0004494" ; a owl:Class ; rdfs:label "methylmalonyl-CoA mutase activity" ; rdfs:subClassOf obo:GO_0016866 . obo:GO_0004553 obo:IAO_0000115 "Catalysis of the hydrolysis of any O-glycosyl bond." ; oboInOwl:hasAlternativeId "GO:0016800" ; oboInOwl:hasDbXref "EC:3.2.1.-", "Reactome:R-HSA-5694563", "Reactome:R-HSA-6786652", "Reactome:R-HSA-9661820" ; oboInOwl:hasExactSynonym "O-glucosyl hydrolase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0004553" ; a owl:Class ; rdfs:label "hydrolase activity, hydrolyzing O-glycosyl compounds" ; rdfs:subClassOf obo:GO_0016798 . obo:GO_0004556 obo:IAO_0000115 "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22621"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0103025" ; oboInOwl:hasBroadSynonym "glycogenase activity" ; oboInOwl:hasDbXref "EC:3.2.1.1", "MetaCyc:ALPHA-AMYL-RXN", "MetaCyc:RXN-1823", "MetaCyc:RXN-1825", "Reactome:R-HSA-188979", "Reactome:R-HSA-191114" ; oboInOwl:hasNarrowSynonym "alpha-amylase activity (releasing maltohexaose)" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "1,4-alpha-D-glucan glucanohydrolase activity", "alpha amylase activity", "endoamylase activity", "taka-amylase A" ; oboInOwl:id "GO:0004556" ; a owl:Class ; rdfs:label "alpha-amylase activity" ; rdfs:subClassOf obo:GO_0016160 . obo:GO_0004565 obo:IAO_0000115 "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." ; oboInOwl:hasDbXref "EC:3.2.1.23", "MetaCyc:3.2.1.23-RXN", "MetaCyc:BGALACT-PWY", "Reactome:R-HSA-1605624", "Reactome:R-HSA-1606312", "Reactome:R-HSA-1630306", "Reactome:R-HSA-1793217", "Reactome:R-HSA-2090079", "Reactome:R-HSA-2265534", "Reactome:R-HSA-9036061" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "beta-D-galactanase activity", "beta-D-galactoside galactohydrolase activity", "beta-D-lactosidase activity", "beta-lactosidase activity", "exo-(1->4)-beta-D-galactanase activity", "hydrolact" ; oboInOwl:id "GO:0004565" ; a owl:Class ; rdfs:comment "Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase." ; rdfs:label "beta-galactosidase activity" ; rdfs:subClassOf obo:GO_0015925 . obo:GO_0004618 obo:IAO_0000115 "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+." ; oboInOwl:hasDbXref "EC:2.7.2.3", "KEGG_REACTION:R01512", "MetaCyc:PHOSGLYPHOS-RXN", "RHEA:14801", "Reactome:R-HSA-70486", "Reactome:R-HSA-71850" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "3-PGK", "3-phosphoglycerate kinase activity", "3-phosphoglycerate phosphokinase activity", "3-phosphoglyceric acid kinase activity", "3-phosphoglyceric acid phosphokinase activity", "3-phosphoglyceric kinase activity", "ATP-3-phospho-D-glycerate-1-phosphotransferase activity", "ATP:3-phospho-D-glycerate 1-phosphotransferase activity", "ATP:D-3-phosphoglycerate 1-phosphotransferase activity", "PGK", "glycerate 3-phosphate kinase activity", "glycerophosphate kinase activity", "phosphoglyceric acid kinase activity", "phosphoglyceric kinase activity", "phosphoglycerokinase activity" ; oboInOwl:id "GO:0004618" ; a owl:Class ; rdfs:label "phosphoglycerate kinase activity" ; rdfs:subClassOf obo:GO_0016301, obo:GO_0016774 . obo:GO_0004619 obo:IAO_0000115 "Catalysis of the reaction: 2-phosphoglycerate = 3-phosphoglycerate." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24905"^^xsd:anyURI ; oboInOwl:hasDbXref "MetaCyc:3PGAREARR-RXN", "RHEA:15901", "Reactome:R-HSA-71445", "Reactome:R-HSA-71654" ; oboInOwl:hasExactSynonym "PGM" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "D-phosphoglycerate 2,3-phosphomutase activity", "PGA mutase activity", "PGAM activity", "phosphoglycerate phosphomutase activity", "phosphoglyceromutase activity" ; oboInOwl:id "GO:0004619" ; a owl:Class ; rdfs:label "phosphoglycerate mutase activity" ; rdfs:subClassOf obo:GO_0016868 . obo:GO_0004634 obo:IAO_0000115 "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." ; oboInOwl:hasDbXref "EC:4.2.1.11", "MetaCyc:2PGADEHYDRAT-RXN", "RHEA:10164", "Reactome:R-HSA-70494", "Reactome:R-HSA-71660" ; oboInOwl:hasExactSynonym "2-phospho-D-glycerate-hydrolase activity" ; oboInOwl:hasNarrowSynonym "nervous-system specific enolase" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "14-3-2-protein", "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)", "2-phospho-D-glycerate hydro-lyase activity", "2-phosphoglycerate dehydratase activity", "2-phosphoglycerate enolase activity", "2-phosphoglyceric dehydratase activity", "enolase activity", "gamma-enolase activity", "phosphoenolpyruvate hydratase activity" ; oboInOwl:id "GO:0004634" ; a owl:Class ; rdfs:label "phosphopyruvate hydratase activity" ; rdfs:subClassOf obo:GO_0016836 . obo:GO_0004658 obo:IAO_0000115 "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." ; oboInOwl:hasDbXref "EC:6.4.1.3", "MetaCyc:PROPIONYL-COA-CARBOXY-RXN", "RHEA:23720", "Reactome:R-HSA-71031" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "PCCase activity", "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)", "propionyl coenzyme A carboxylase activity" ; oboInOwl:id "GO:0004658" ; a owl:Class ; rdfs:label "propionyl-CoA carboxylase activity" ; rdfs:subClassOf obo:GO_0016421 . obo:GO_0004736 obo:IAO_0000115 "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate." ; oboInOwl:hasDbXref "EC:6.4.1.1", "KEGG_REACTION:R00344", "MetaCyc:PYRUVATE-CARBOXYLASE-RXN", "RHEA:20844", "Reactome:R-HSA-70501" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "pyruvate:carbon-dioxide ligase (ADP-forming)", "pyruvic carboxylase activity" ; oboInOwl:id "GO:0004736" ; a owl:Class ; rdfs:label "pyruvate carboxylase activity" ; rdfs:subClassOf obo:GO_0016885 . obo:GO_0004888 obo:IAO_0000115 "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." ; oboInOwl:hasAlternativeId "GO:0004926", "GO:0099600" ; oboInOwl:hasBroadSynonym "transmembrane receptor activity" ; oboInOwl:hasDbXref "Reactome:R-HSA-193672" ; oboInOwl:hasExactSynonym "transmembrane signalling receptor activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0004888" ; a owl:Class ; rdfs:comment "This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores." ; rdfs:label "transmembrane signaling receptor activity" ; rdfs:subClassOf obo:GO_0038023 . obo:GO_0004930 obo:IAO_0000115 "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." ; oboInOwl:hasAlternativeId "GO:0001622", "GO:0001623", "GO:0001624", "GO:0001625", "GO:0016526" ; oboInOwl:hasDbXref "Reactome:R-HSA-114552", "Reactome:R-HSA-114558", "Reactome:R-HSA-167408", "Wikipedia:GPCR" ; oboInOwl:hasExactSynonym "G protein coupled receptor activity", "G protein linked receptor activity", "G-protein coupled receptor activity", "G-protein linked receptor activity", "GPCR activity", "ligand-dependent GPCR activity", "receptor activity, G-protein coupled" ; oboInOwl:hasNarrowSynonym "EBV-induced receptor", "Epstein-Barr Virus-induced receptor activity", "G-protein coupled receptor activity, unknown ligand", "Mas proto-oncogene receptor activity", "RDC1 receptor activity", "SREB receptor", "orphan G protein coupled receptor activity", "orphan G-protein coupled receptor activity", "orphan GPCR activity", "super conserved receptor expressed in brain receptor activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0004930" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "G protein-coupled receptor activity" ; rdfs:subClassOf obo:GO_0004888, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007186 ] . obo:GO_0005215 obo:IAO_0000115 "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." ; oboInOwl:hasAlternativeId "GO:0005478" ; oboInOwl:hasDbXref "Reactome:R-HSA-168313", "Reactome:R-HSA-178215" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "carrier" ; oboInOwl:id "GO:0005215" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ; rdfs:label "transporter activity" ; rdfs:subClassOf obo:GO_0003674 . obo:GO_0005575 obo:IAO_0000115 "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." ; oboInOwl:hasAlternativeId "GO:0008372" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1337158144" ; oboInOwl:hasExactSynonym "cell or subcellular entity", "cellular component" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "subcellular entity" ; oboInOwl:id "GO:0005575" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ; rdfs:label "cellular_component" . obo:GO_0005576 obo:IAO_0000115 "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." ; oboInOwl:hasDbXref "Wikipedia:Extracellular" ; oboInOwl:hasExactSynonym "extracellular" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005576" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." ; rdfs:label "extracellular region" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0005577 obo:IAO_0000115 "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." ; oboInOwl:hasExactSynonym "fibrinogen" ; oboInOwl:hasNarrowSynonym "fibrinogen alpha chain", "fibrinogen beta chain", "fibrinogen gamma chain" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005577" ; a owl:Class ; rdfs:label "fibrinogen complex" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005615 ] . obo:GO_0005581 obo:IAO_0000115 "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." ; oboInOwl:hasDbXref "Wikipedia:Collagen" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005581" ; a owl:Class ; rdfs:label "collagen trimer" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0005583 obo:IAO_0000115 "Any triple helical collagen trimer that forms fibrils." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005583" ; a owl:Class ; rdfs:label "fibrillar collagen trimer" ; rdfs:subClassOf obo:GO_0005581, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098643 ] ; owl:disjointWith obo:GO_0030936 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005581 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098643 ] ) ] . obo:GO_0005584 obo:IAO_0000115 "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." ; oboInOwl:hasDbXref "Wikipedia:Collagen_type_I" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005584" ; a owl:Class ; rdfs:label "collagen type I trimer" ; rdfs:subClassOf obo:GO_0005583 . obo:GO_0005585 obo:IAO_0000115 "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." ; oboInOwl:hasDbXref "Wikipedia:Collagen_type_II" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005585" ; a owl:Class ; rdfs:label "collagen type II trimer" ; rdfs:subClassOf obo:GO_0005583 . obo:GO_0005587 obo:IAO_0000115 "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." ; oboInOwl:hasDbXref "Wikipedia:Collagen_type_IV" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005587" ; a owl:Class ; rdfs:label "collagen type IV trimer" ; rdfs:subClassOf obo:GO_0098642, obo:GO_0098651 . obo:GO_0005604 obo:IAO_0000115 "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." ; oboInOwl:hasAlternativeId "GO:0005605", "GO:0008003" ; oboInOwl:hasDbXref "Wikipedia:Basement_membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "basal lamina", "basement lamina", "lamina densa" ; oboInOwl:id "GO:0005604" ; a owl:Class ; rdfs:comment "Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer." ; rdfs:label "basement membrane" ; rdfs:subClassOf obo:GO_0062023 . obo:GO_0005615 obo:IAO_0000115 "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1425028079" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "intercellular space" ; oboInOwl:id "GO:0005615" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term." ; rdfs:label "extracellular space" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] . obo:GO_0005622 obo:IAO_0000115 "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/17776"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Intracellular" ; oboInOwl:hasExactSynonym "internal to cell", "intracellular", "protoplasm" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "nucleocytoplasm", "protoplast" ; oboInOwl:id "GO:0005622" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_chembl, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:label "intracellular anatomical structure" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0005623 obo:IAO_0000115 "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19036"^^xsd:anyURI ; obo:IAO_0000589 "cell and encapsulating structures" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1813327414", "Wikipedia:Cell_(biology)" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005623" ; a owl:Class ; rdfs:comment "This term was obsoleted because it was redundant with the root class of the cell ontology, CL:0000000." ; rdfs:label "obsolete cell" ; owl:deprecated true . obo:GO_0005634 obo:IAO_0000115 "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1702920020", "Wikipedia:Cell_nucleus" ; oboInOwl:hasExactSynonym "cell nucleus" ; oboInOwl:hasNarrowSynonym "horsetail nucleus" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005634" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:label "nucleus" ; rdfs:subClassOf obo:GO_0043231 . obo:GO_0005635 obo:IAO_0000115 "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." ; oboInOwl:hasAlternativeId "GO:0005636" ; oboInOwl:hasDbXref "Wikipedia:Nuclear_envelope" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005635" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic, go:goslim_plant ; a owl:Class ; rdfs:label "nuclear envelope" ; rdfs:subClassOf obo:GO_0031967, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0012505 ] . obo:GO_0005694 obo:IAO_0000115 "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." ; oboInOwl:hasDbXref "Wikipedia:Chromosome" ; oboInOwl:hasNarrowSynonym "interphase chromosome", "prophase chromosome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "chromatid" ; oboInOwl:id "GO:0005694" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ; rdfs:label "chromosome" ; rdfs:subClassOf obo:GO_0043232 . obo:GO_0005730 obo:IAO_0000115 "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1820400233", "Wikipedia:Nucleolus" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005730" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:label "nucleolus" ; rdfs:subClassOf obo:GO_0043232, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031981 ] . obo:GO_0005737 obo:IAO_0000115 "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23023"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Cytoplasm" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005737" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "cytoplasm" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] . obo:GO_0005739 obo:IAO_0000115 "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1860313010", "Wikipedia:Mitochondrion" ; oboInOwl:hasExactSynonym "mitochondria" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005739" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:comment "Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)" ; rdfs:label "mitochondrion" ; rdfs:subClassOf obo:GO_0043231, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] . obo:GO_0005740 obo:IAO_0000115 "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005740" ; oboInOwl:inSubset go:goslim_candida, go:goslim_yeast ; a owl:Class ; rdfs:label "mitochondrial envelope" ; rdfs:subClassOf obo:GO_0031967, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] . obo:GO_0005743 obo:IAO_0000115 "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1371347282", "Wikipedia:Inner_mitochondrial_membrane" ; oboInOwl:hasExactSynonym "inner mitochondrial membrane", "inner mitochondrion membrane", "mitochondrion inner membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005743" ; a owl:Class ; rdfs:label "mitochondrial inner membrane" ; rdfs:subClassOf obo:GO_0019866, obo:GO_0031966 . obo:GO_0005746 obo:IAO_0000115 "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/12846"^^xsd:anyURI ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-02-23T05:13:54Z" ; oboInOwl:hasAlternativeId "GO:0097249" ; oboInOwl:hasExactSynonym "mitochondrial electron transport chain", "mitochondrial respiratory chain", "mitochondrial respiratory chain supercomplex", "mitochondrial respiratory supercomplex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005746" ; a owl:Class ; rdfs:label "mitochondrial respirasome" ; rdfs:subClassOf obo:GO_0070469, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0070469 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005743 ] ) ] . obo:GO_0005753 obo:IAO_0000115 "A proton-transporting ATP synthase complex found in the mitochondrial membrane." ; oboInOwl:hasAlternativeId "GO:0016470" ; oboInOwl:hasExactSynonym "mitochondrial respiratory chain complex V" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005753" ; a owl:Class ; rdfs:label "mitochondrial proton-transporting ATP synthase complex" ; rdfs:subClassOf obo:GO_0045259, obo:GO_0098800 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045259 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0005759 obo:IAO_0000115 "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." ; oboInOwl:hasAlternativeId "GO:0031980" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1804523077", "Wikipedia:Mitochondrial_matrix" ; oboInOwl:hasExactSynonym "mitochondrial lumen" ; oboInOwl:hasNarrowSynonym "mitochondrial stroma" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005759" ; a owl:Class ; rdfs:label "mitochondrial matrix" ; rdfs:subClassOf obo:GO_0070013, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] . obo:GO_0005761 obo:IAO_0000115 "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." ; oboInOwl:hasNarrowSynonym "55S ribosome, mitochondrial" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005761" ; a owl:Class ; rdfs:label "mitochondrial ribosome" ; rdfs:subClassOf obo:GO_0000313, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005759 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005840 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005759 ] ) ] . obo:GO_0005764 obo:IAO_0000115 "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." ; oboInOwl:hasDbXref "NIF_Subcellular:sao585356902", "Wikipedia:Lysosome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005764" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic, go:goslim_plant ; a owl:Class ; rdfs:label "lysosome" ; rdfs:subClassOf obo:GO_0000323 . obo:GO_0005766 obo:IAO_0000115 "A lysosome before it has fused with a vesicle or vacuole." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1140587416" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005766" ; a owl:Class ; rdfs:label "primary lysosome" ; rdfs:subClassOf obo:GO_0005764 . obo:GO_0005773 obo:IAO_0000115 "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." ; oboInOwl:hasDbXref "Wikipedia:Vacuole" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "vacuolar carboxypeptidase Y" ; oboInOwl:id "GO:0005773" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:label "vacuole" ; rdfs:subClassOf obo:GO_0043231, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] . obo:GO_0005775 obo:IAO_0000115 "The volume enclosed within the vacuolar membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005775" ; a owl:Class ; rdfs:label "vacuolar lumen" ; rdfs:subClassOf obo:GO_0070013, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031974 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005773 ] ) ] . obo:GO_0005840 obo:IAO_0000115 "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." ; oboInOwl:hasAlternativeId "GO:0033279" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1429207766", "Wikipedia:Ribosome" ; oboInOwl:hasNarrowSynonym "free ribosome", "membrane bound ribosome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "ribosomal RNA" ; oboInOwl:id "GO:0005840" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "ribosome" ; rdfs:subClassOf obo:GO_0043232 . obo:GO_0005856 obo:IAO_0000115 "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." ; oboInOwl:hasDbXref "Wikipedia:Cytoskeleton" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005856" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "cytoskeleton" ; rdfs:subClassOf obo:GO_0043232 . obo:GO_0005882 obo:IAO_0000115 "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." ; oboInOwl:hasDbXref "FMA:63851", "NIF_Subcellular:sao952483289", "Wikipedia:Intermediate_filament" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "intermediate filament associated protein", "type I intermediate filament associated protein", "type II intermediate filament associated protein" ; oboInOwl:id "GO:0005882" ; a owl:Class ; rdfs:label "intermediate filament" ; rdfs:subClassOf obo:GO_0099513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0045111 ] . obo:GO_0005884 obo:IAO_0000115 "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." ; oboInOwl:hasDbXref "FMA:63850", "NIF_Subcellular:sao1588493326", "Wikipedia:Actin" ; oboInOwl:hasExactSynonym "microfilament" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005884" ; a owl:Class ; rdfs:label "actin filament" ; rdfs:subClassOf obo:GO_0099513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0015629 ] . obo:GO_0005886 obo:IAO_0000115 "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." ; oboInOwl:hasAlternativeId "GO:0005887", "GO:0005904" ; oboInOwl:hasBroadSynonym "juxtamembrane" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1663586795", "Wikipedia:Cell_membrane" ; oboInOwl:hasExactSynonym "cell membrane", "cellular membrane", "cytoplasmic membrane", "plasmalemma" ; oboInOwl:hasNarrowSynonym "bacterial inner membrane", "inner endospore membrane", "integral component of plasma membrane", "integral to plasma membrane", "plasma membrane lipid bilayer" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005886" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "plasma membrane" ; rdfs:subClassOf obo:GO_0016020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0071944 ] . obo:GO_0005902 obo:IAO_0000115 "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." ; oboInOwl:hasDbXref "NIF_Subcellular:sao671419673", "Wikipedia:Microvillus" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "microvilli" ; oboInOwl:id "GO:0005902" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:comment "Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta." ; rdfs:label "microvillus" ; rdfs:subClassOf obo:GO_0098858, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0032432 ] . obo:GO_0005911 obo:IAO_0000115 "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22122"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "cell-cell contact region", "cell-cell contact zone" ; oboInOwl:hasDbXref "NIF_Subcellular:sao1922892319" ; oboInOwl:hasExactSynonym "intercellular junction" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0005911" ; a owl:Class ; rdfs:label "cell-cell junction" ; rdfs:subClassOf obo:GO_0070161 . obo:GO_0005929 obo:IAO_0000115 "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." ; obo:RO_0002161 obo:NCBITaxon_3176, obo:NCBITaxon_3312, obo:NCBITaxon_3378, obo:NCBITaxon_3398, obo:NCBITaxon_4890, obo:NCBITaxon_5782 ; oboInOwl:hasAlternativeId "GO:0072372" ; oboInOwl:hasDbXref "FMA:67181", "NIF_Subcellular:sao787716553", "Wikipedia:Cilium" ; oboInOwl:hasExactSynonym "eukaryotic flagellum", "microtubule-based flagellum" ; oboInOwl:hasNarrowSynonym "primary cilium" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "flagellum" ; oboInOwl:id "GO:0005929" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms." ; rdfs:label "cilium" ; rdfs:subClassOf obo:GO_0043227, obo:GO_0120025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030990 ] . obo:GO_0005938 obo:IAO_0000115 "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." ; oboInOwl:hasDbXref "Wikipedia:Cell_cortex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "cell periphery", "peripheral cytoplasm" ; oboInOwl:id "GO:0005938" ; oboInOwl:inSubset go:goslim_candida, go:goslim_yeast ; a owl:Class ; rdfs:label "cell cortex" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0071944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0071944 ] ) ] . obo:GO_0005975 obo:IAO_0000115 "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22880"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-10-23T15:40:34Z" ; oboInOwl:hasAlternativeId "GO:0044261", "GO:0044723" ; oboInOwl:hasDbXref "Wikipedia:Carbohydrate_metabolism" ; oboInOwl:hasExactSynonym "carbohydrate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005975" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "carbohydrate metabolic process" ; rdfs:subClassOf obo:GO_0044238, obo:GO_0071704 . obo:GO_0005976 obo:IAO_0000115 "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." ; oboInOwl:hasAlternativeId "GO:0044263" ; oboInOwl:hasExactSynonym "polysaccharide metabolism" ; oboInOwl:hasNarrowSynonym "glycan metabolic process", "glycan metabolism", "multicellular organismal polysaccharide metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005976" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "polysaccharide metabolic process" ; rdfs:subClassOf obo:GO_0005975, obo:GO_0043170 . obo:GO_0005977 obo:IAO_0000115 "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." ; oboInOwl:hasExactSynonym "glycogen metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005977" ; a owl:Class ; rdfs:label "glycogen metabolic process" ; rdfs:subClassOf obo:GO_0006112, obo:GO_0044042 . obo:GO_0005978 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." ; oboInOwl:hasDbXref "MetaCyc:GLYCOGENSYNTH-PWY" ; oboInOwl:hasExactSynonym "glycogen anabolism", "glycogen biosynthesis", "glycogen formation", "glycogen synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005978" ; a owl:Class ; rdfs:label "glycogen biosynthetic process" ; rdfs:subClassOf obo:GO_0005977, obo:GO_0009250 . obo:GO_0005979 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." ; oboInOwl:hasExactSynonym "regulation of glycogen anabolism", "regulation of glycogen biosynthesis", "regulation of glycogen formation", "regulation of glycogen synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005979" ; a owl:Class ; rdfs:label "regulation of glycogen biosynthetic process" ; rdfs:subClassOf obo:GO_0010962, obo:GO_0070873, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005978 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005978 ] ) ] . obo:GO_0005980 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." ; oboInOwl:hasDbXref "MetaCyc:GLYCOCAT-PWY" ; oboInOwl:hasExactSynonym "glycogen breakdown", "glycogen catabolism", "glycogen degradation", "glycogenolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005980" ; a owl:Class ; rdfs:label "glycogen catabolic process" ; rdfs:subClassOf obo:GO_0005977, obo:GO_0009251 . obo:GO_0005981 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." ; oboInOwl:hasExactSynonym "regulation of glycogen breakdown", "regulation of glycogen catabolism", "regulation of glycogen degradation", "regulation of glycogenolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005981" ; a owl:Class ; rdfs:label "regulation of glycogen catabolic process" ; rdfs:subClassOf obo:GO_0043470, obo:GO_0070873, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005980 ] ) ] . obo:GO_0005996 obo:IAO_0000115 "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." ; oboInOwl:hasExactSynonym "monosaccharide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0005996" ; a owl:Class ; rdfs:label "monosaccharide metabolic process" ; rdfs:subClassOf obo:GO_0005975, obo:GO_0044281 . obo:GO_0006000 obo:IAO_0000115 "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." ; oboInOwl:hasDbXref "Wikipedia:Fructose" ; oboInOwl:hasExactSynonym "fructose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006000" ; a owl:Class ; rdfs:label "fructose metabolic process" ; rdfs:subClassOf obo:GO_0019318 . obo:GO_0006006 obo:IAO_0000115 "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." ; oboInOwl:hasExactSynonym "cellular glucose metabolic process", "glucose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006006" ; a owl:Class ; rdfs:label "glucose metabolic process" ; rdfs:subClassOf obo:GO_0019318 . obo:GO_0006012 obo:IAO_0000115 "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." ; oboInOwl:hasDbXref "Wikipedia:Galactose" ; oboInOwl:hasExactSynonym "galactose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006012" ; a owl:Class ; rdfs:label "galactose metabolic process" ; rdfs:subClassOf obo:GO_0019318 . obo:GO_0006022 obo:IAO_0000115 "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." ; oboInOwl:hasExactSynonym "aminoglycan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006022" ; a owl:Class ; rdfs:label "aminoglycan metabolic process" ; rdfs:subClassOf obo:GO_0043170, obo:GO_1901135, obo:GO_1901564 . obo:GO_0006023 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." ; oboInOwl:hasExactSynonym "aminoglycan anabolism", "aminoglycan biosynthesis", "aminoglycan formation", "aminoglycan synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006023" ; a owl:Class ; rdfs:label "aminoglycan biosynthetic process" ; rdfs:subClassOf obo:GO_0006022, obo:GO_0009059, obo:GO_1901137, obo:GO_1901566 . obo:GO_0006024 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." ; oboInOwl:hasExactSynonym "glycosaminoglycan anabolism", "glycosaminoglycan biosynthesis", "glycosaminoglycan formation", "glycosaminoglycan synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006024" ; a owl:Class ; rdfs:label "glycosaminoglycan biosynthetic process" ; rdfs:subClassOf obo:GO_0006023, obo:GO_0030203 . obo:GO_0006066 obo:IAO_0000115 "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." ; oboInOwl:hasExactSynonym "alcohol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006066" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_pir ; a owl:Class ; rdfs:label "alcohol metabolic process" ; rdfs:subClassOf obo:GO_0044281, obo:GO_1901615 . obo:GO_0006081 obo:IAO_0000115 "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." ; oboInOwl:hasExactSynonym "aldehyde metabolism", "alkanal metabolic process", "alkanal metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006081" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular aldehyde metabolic process" ; rdfs:subClassOf obo:GO_0044237, obo:GO_0071704 . obo:GO_0006082 obo:IAO_0000115 "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." ; oboInOwl:hasExactSynonym "organic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006082" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "organic acid metabolic process" ; rdfs:subClassOf obo:GO_0044237, obo:GO_0044281, obo:GO_0071704 . obo:GO_0006089 obo:IAO_0000115 "The chemical reactions and pathways involving lactate, the anion of lactic acid." ; oboInOwl:hasExactSynonym "2-hydroxypropanoate metabolic process", "2-hydroxypropanoate metabolism", "alpha-hydroxypropionate metabolic process", "alpha-hydroxypropionate metabolism", "lactate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006089" ; a owl:Class ; rdfs:label "lactate metabolic process" ; rdfs:subClassOf obo:GO_0032787, obo:GO_1901615 . obo:GO_0006090 obo:IAO_0000115 "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." ; oboInOwl:hasAlternativeId "GO:0006087" ; oboInOwl:hasDbXref "MetaCyc:P41-PWY", "Wikipedia:Pyruvic_acid" ; oboInOwl:hasExactSynonym "pyruvate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pyruvate dehydrogenase bypass" ; oboInOwl:id "GO:0006090" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "pyruvate metabolic process" ; rdfs:subClassOf obo:GO_0032787 . obo:GO_0006091 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." ; oboInOwl:hasBroadSynonym "energy pathways" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intermediary metabolism", "metabolic energy generation" ; oboInOwl:id "GO:0006091" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "generation of precursor metabolites and energy" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0006094 obo:IAO_0000115 "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." ; oboInOwl:hasDbXref "MetaCyc:GLUCONEO-PWY", "Wikipedia:Gluconeogenesis" ; oboInOwl:hasExactSynonym "glucose biosynthesis", "glucose biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006094" ; a owl:Class ; rdfs:label "gluconeogenesis" ; rdfs:subClassOf obo:GO_0006006, obo:GO_0019319 . obo:GO_0006096 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21176"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0019641", "GO:0019642" ; oboInOwl:hasDbXref "MetaCyc:GLYCOLYSIS-VARIANTS" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "Embden-Meyerhof pathway", "Embden-Meyerhof-Parnas pathway", "anaerobic glycolysis", "glycolysis", "modifed Embden-Meyerhof pathway" ; oboInOwl:id "GO:0006096" ; a owl:Class ; rdfs:label "glycolytic process" ; rdfs:subClassOf obo:GO_0006090, obo:GO_0006091, obo:GO_0016052, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0004618 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0004619 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0004634 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043891 ] . obo:GO_0006109 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." ; oboInOwl:hasExactSynonym "regulation of carbohydrate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006109" ; a owl:Class ; rdfs:label "regulation of carbohydrate metabolic process" ; rdfs:subClassOf obo:GO_0080090, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005975 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005975 ] ) ] . obo:GO_0006110 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glycolysis." ; oboInOwl:hasAlternativeId "GO:0090525" ; oboInOwl:hasExactSynonym "regulation of glycolysis involved in cellular glucose homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006110" ; a owl:Class ; rdfs:label "regulation of glycolytic process" ; rdfs:subClassOf obo:GO_0043467, obo:GO_0043470, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006096 ] ) ] . obo:GO_0006111 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2013-01-18T12:47:43Z" ; oboInOwl:hasAlternativeId "GO:0090526" ; oboInOwl:hasBroadSynonym "regulation of glucose biosynthesis", "regulation of glucose biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of gluconeogenesis involved in cellular glucose homeostasis" ; oboInOwl:id "GO:0006111" ; a owl:Class ; rdfs:label "regulation of gluconeogenesis" ; rdfs:subClassOf obo:GO_0010906, obo:GO_0043255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006094 ] ) ] . obo:GO_0006112 obo:IAO_0000115 "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." ; oboInOwl:hasExactSynonym "energy reserve metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006112" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "energy reserve metabolic process" ; rdfs:subClassOf obo:GO_0015980 . obo:GO_0006139 obo:IAO_0000115 "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." ; oboInOwl:hasAlternativeId "GO:0055134" ; oboInOwl:hasExactSynonym "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nucleobase, nucleoside and nucleotide metabolic process", "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:id "GO:0006139" ; oboInOwl:inSubset go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "nucleobase-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_0034641, obo:GO_0044238, obo:GO_0046483, obo:GO_1901360 . obo:GO_0006141 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." ; oboInOwl:hasExactSynonym "regulation of purine base metabolic process", "regulation of purine base metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006141" ; a owl:Class ; rdfs:label "regulation of purine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0019219, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006144 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006144 ] ) ] . obo:GO_0006142 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." ; oboInOwl:hasExactSynonym "regulation of pyrimidine base metabolic process", "regulation of pyrimidine base metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006142" ; a owl:Class ; rdfs:label "regulation of pyrimidine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0019219, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006206 ] ) ] . obo:GO_0006144 obo:IAO_0000115 "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." ; oboInOwl:hasExactSynonym "purine base metabolic process", "purine base metabolism" ; oboInOwl:hasNarrowSynonym "purine metabolic process", "purine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006144" ; a owl:Class ; rdfs:label "purine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0009112, obo:GO_0072521 . obo:GO_0006206 obo:IAO_0000115 "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." ; oboInOwl:hasExactSynonym "pyrimidine base metabolic process", "pyrimidine base metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pyrimidine metabolic process", "pyrimidine metabolism" ; oboInOwl:id "GO:0006206" ; a owl:Class ; rdfs:label "pyrimidine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0009112, obo:GO_0072527 . obo:GO_0006259 obo:IAO_0000115 "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." ; oboInOwl:hasAlternativeId "GO:0055132" ; oboInOwl:hasExactSynonym "DNA metabolism", "cellular DNA metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006259" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "DNA metabolic process" ; rdfs:subClassOf obo:GO_0090304 . obo:GO_0006281 obo:IAO_0000115 "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." ; oboInOwl:hasDbXref "Wikipedia:DNA_repair" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006281" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "DNA repair" ; rdfs:subClassOf obo:GO_0006259, obo:GO_0006974 . obo:GO_0006282 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of DNA repair." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006282" ; oboInOwl:inSubset go:goslim_metagenomics ; a owl:Class ; rdfs:label "regulation of DNA repair" ; rdfs:subClassOf obo:GO_0051052, obo:GO_0080135, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006281 ] ) ] . obo:GO_0006310 obo:IAO_0000115 "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006310" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "DNA recombination" ; rdfs:subClassOf obo:GO_0006259 . obo:GO_0006325 obo:IAO_0000115 "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22130"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/23549"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0006333", "GO:0006336", "GO:0016568", "GO:0031497", "GO:0034724" ; oboInOwl:hasBroadSynonym "chromatin maintenance" ; oboInOwl:hasExactSynonym "chromatin organisation", "establishment of chromatin architecture", "establishment or maintenance of chromatin architecture" ; oboInOwl:hasNarrowSynonym "DNA replication-independent chromatin assembly", "DNA replication-independent chromatin organization", "DNA replication-independent nucleosome organisation", "DNA replication-independent nuclesome assembly", "chromatin assembly", "transcription-coupled nucleosome assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chromatin assembly or disassembly", "chromatin assembly/disassembly", "chromatin modification" ; oboInOwl:id "GO:0006325" ; oboInOwl:inSubset go:goslim_generic, go:goslim_pombe, go:goslim_yeast ; a owl:Class ; rdfs:label "chromatin organization" ; rdfs:subClassOf obo:GO_0071824 . obo:GO_0006338 obo:IAO_0000115 "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21732"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/21748"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0043044" ; oboInOwl:hasExactSynonym "chromatin modeling", "chromatin modelling", "chromatin remodelling" ; oboInOwl:hasNarrowSynonym "ATP-dependent chromatin remodeling", "ATP-dependent chromatin remodelling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006338" ; a owl:Class ; rdfs:label "chromatin remodeling" ; rdfs:subClassOf obo:GO_0006325 . obo:GO_0006412 obo:IAO_0000115 "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." ; oboInOwl:hasAlternativeId "GO:0006416", "GO:0006453", "GO:0043037" ; oboInOwl:hasDbXref "Wikipedia:Translation_(genetics)" ; oboInOwl:hasExactSynonym "protein anabolism", "protein biosynthesis", "protein biosynthetic process", "protein formation", "protein synthesis", "protein translation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006412" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:prokaryote_subset ; a owl:Class ; rdfs:label "translation" ; rdfs:subClassOf obo:GO_0009059, obo:GO_0019538, obo:GO_0043043, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010467 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0006414 ] . obo:GO_0006414 obo:IAO_0000115 "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." ; oboInOwl:hasAlternativeId "GO:0006442", "GO:0006455" ; oboInOwl:hasBroadSynonym "protein synthesis elongation" ; oboInOwl:hasExactSynonym "translation elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006414" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "translational elongation" ; rdfs:subClassOf obo:GO_0009059, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006412 ] . obo:GO_0006417 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." ; oboInOwl:hasAlternativeId "GO:0006445" ; oboInOwl:hasExactSynonym "regulation of protein anabolism", "regulation of protein biosynthesis", "regulation of protein formation", "regulation of protein synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006417" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of translation" ; rdfs:subClassOf obo:GO_0010556, obo:GO_0010608, obo:GO_0031326, obo:GO_0034248, obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0006448 obo:IAO_0000115 "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006448" ; a owl:Class ; rdfs:label "regulation of translational elongation" ; rdfs:subClassOf obo:GO_0006417, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006414 ] ) ] . obo:GO_0006486 obo:IAO_0000115 "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." ; oboInOwl:hasAlternativeId "GO:0065006" ; oboInOwl:hasExactSynonym "protein amino acid glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "protein-carbohydrate complex assembly" ; oboInOwl:id "GO:0006486" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_generic, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "protein glycosylation" ; rdfs:subClassOf obo:GO_0036211, obo:GO_0043413, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009101 ] . obo:GO_0006487 obo:IAO_0000115 "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." ; oboInOwl:hasDbXref "RESID:AA0151", "RESID:AA0156", "RESID:AA0327" ; oboInOwl:hasExactSynonym "protein amino acid N-linked glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "N-glycan biosynthesis", "N-glycan metabolism" ; oboInOwl:id "GO:0006487" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "protein N-linked glycosylation" ; rdfs:subClassOf obo:GO_0006486 . obo:GO_0006493 obo:IAO_0000115 "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." ; oboInOwl:hasDbXref "RESID:AA0153", "RESID:AA0154", "RESID:AA0155", "RESID:AA0157", "RESID:AA0212" ; oboInOwl:hasExactSynonym "protein amino acid O-linked glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006493" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "protein O-linked glycosylation" ; rdfs:subClassOf obo:GO_0006486 . obo:GO_0006508 obo:IAO_0000115 "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." ; oboInOwl:hasDbXref "Wikipedia:Proteolysis" ; oboInOwl:hasExactSynonym "peptidolysis" ; oboInOwl:hasNarrowSynonym "ATP-dependent proteolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006508" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir ; a owl:Class ; rdfs:comment "This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing." ; rdfs:label "proteolysis" ; rdfs:subClassOf obo:GO_0019538 . obo:GO_0006518 obo:IAO_0000115 "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." ; oboInOwl:hasExactSynonym "peptide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006518" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "peptide metabolic process" ; rdfs:subClassOf obo:GO_0043603, obo:GO_1901564 . obo:GO_0006520 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/17904"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0006519" ; oboInOwl:hasExactSynonym "cellular amino acid metabolic process", "cellular amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "amino acid and derivative metabolism", "cellular amino acid and derivative metabolic process" ; oboInOwl:id "GO:0006520" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "amino acid metabolic process" ; rdfs:subClassOf obo:GO_0019752, obo:GO_0044238, obo:GO_1901564 . obo:GO_0006521 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." ; oboInOwl:hasExactSynonym "regulation of amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006521" ; a owl:Class ; rdfs:label "regulation of cellular amino acid metabolic process" ; rdfs:subClassOf obo:GO_0010565, obo:GO_0033238, obo:GO_0080090, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006520 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006520 ] ) ] . obo:GO_0006525 obo:IAO_0000115 "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." ; oboInOwl:hasDbXref "Wikipedia:Arginine" ; oboInOwl:hasExactSynonym "arginine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006525" ; a owl:Class ; rdfs:label "arginine metabolic process" ; rdfs:subClassOf obo:GO_0009064 . obo:GO_0006534 obo:IAO_0000115 "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." ; oboInOwl:hasDbXref "Wikipedia:Cysteine_metabolism" ; oboInOwl:hasExactSynonym "cysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006534" ; a owl:Class ; rdfs:label "cysteine metabolic process" ; rdfs:subClassOf obo:GO_0000096, obo:GO_0009069 . obo:GO_0006541 obo:IAO_0000115 "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." ; oboInOwl:hasExactSynonym "glutamine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006541" ; a owl:Class ; rdfs:label "glutamine metabolic process" ; rdfs:subClassOf obo:GO_0009064 . obo:GO_0006544 obo:IAO_0000115 "The chemical reactions and pathways involving glycine, aminoethanoic acid." ; oboInOwl:hasExactSynonym "glycine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006544" ; a owl:Class ; rdfs:label "glycine metabolic process" ; rdfs:subClassOf obo:GO_0009069 . obo:GO_0006547 obo:IAO_0000115 "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." ; oboInOwl:hasDbXref "Wikipedia:Histidine" ; oboInOwl:hasExactSynonym "histidine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006547" ; a owl:Class ; rdfs:label "histidine metabolic process" ; rdfs:subClassOf obo:GO_0006520 . obo:GO_0006549 obo:IAO_0000115 "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." ; oboInOwl:hasExactSynonym "isoleucine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006549" ; a owl:Class ; rdfs:label "isoleucine metabolic process" ; rdfs:subClassOf obo:GO_0009081, obo:GO_1901605 . obo:GO_0006551 obo:IAO_0000115 "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." ; oboInOwl:hasExactSynonym "leucine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006551" ; a owl:Class ; rdfs:label "leucine metabolic process" ; rdfs:subClassOf obo:GO_0009081, obo:GO_1901605 . obo:GO_0006553 obo:IAO_0000115 "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." ; oboInOwl:hasDbXref "Wikipedia:Lysine" ; oboInOwl:hasExactSynonym "lysine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006553" ; a owl:Class ; rdfs:label "lysine metabolic process" ; rdfs:subClassOf obo:GO_0009066 . obo:GO_0006555 obo:IAO_0000115 "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." ; oboInOwl:hasBroadSynonym "methionine and threonine metabolic process", "methionine and threonine metabolism" ; oboInOwl:hasDbXref "UM-BBD_pathwayID:met" ; oboInOwl:hasExactSynonym "methionine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006555" ; a owl:Class ; rdfs:label "methionine metabolic process" ; rdfs:subClassOf obo:GO_0000096, obo:GO_0009066 . obo:GO_0006558 obo:IAO_0000115 "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." ; oboInOwl:hasBroadSynonym "phenylalanine metabolic process", "phenylalanine metabolism" ; oboInOwl:hasExactSynonym "L-phenylalanine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006558" ; a owl:Class ; rdfs:label "L-phenylalanine metabolic process" ; rdfs:subClassOf obo:GO_0009072, obo:GO_1902221 . obo:GO_0006560 obo:IAO_0000115 "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." ; oboInOwl:hasExactSynonym "proline metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006560" ; a owl:Class ; rdfs:label "proline metabolic process" ; rdfs:subClassOf obo:GO_0009064 . obo:GO_0006563 obo:IAO_0000115 "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." ; oboInOwl:hasExactSynonym "L-serine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006563" ; a owl:Class ; rdfs:label "L-serine metabolic process" ; rdfs:subClassOf obo:GO_0009069 . obo:GO_0006566 obo:IAO_0000115 "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." ; oboInOwl:hasBroadSynonym "methionine and threonine metabolic process", "methionine and threonine metabolism" ; oboInOwl:hasDbXref "UM-BBD_pathwayID:met" ; oboInOwl:hasExactSynonym "threonine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006566" ; a owl:Class ; rdfs:label "threonine metabolic process" ; rdfs:subClassOf obo:GO_0009066 . obo:GO_0006568 obo:IAO_0000115 "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." ; oboInOwl:hasDbXref "Wikipedia:Tryptophan" ; oboInOwl:hasExactSynonym "tryptophan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006568" ; a owl:Class ; rdfs:label "tryptophan metabolic process" ; rdfs:subClassOf obo:GO_0006586, obo:GO_0009072, obo:GO_1901605 . obo:GO_0006570 obo:IAO_0000115 "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." ; oboInOwl:hasDbXref "UM-BBD_pathwayID:tyr", "Wikipedia:Tyrosine" ; oboInOwl:hasExactSynonym "tyrosine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006570" ; a owl:Class ; rdfs:label "tyrosine metabolic process" ; rdfs:subClassOf obo:GO_0009072, obo:GO_1901605 . obo:GO_0006573 obo:IAO_0000115 "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." ; oboInOwl:hasExactSynonym "valine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006573" ; a owl:Class ; rdfs:label "valine metabolic process" ; rdfs:subClassOf obo:GO_0009081, obo:GO_1901605 . obo:GO_0006575 obo:IAO_0000115 "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." ; oboInOwl:hasExactSynonym "amino acid derivative metabolic process", "cellular amino acid derivative metabolic process", "cellular amino acid derivative metabolism", "cellular modified amino acid metabolism", "modified amino acid metabolic process", "modified amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006575" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic, go:prokaryote_subset ; a owl:Class ; rdfs:label "cellular modified amino acid metabolic process" ; rdfs:subClassOf obo:GO_0044237, obo:GO_1901564 . obo:GO_0006576 obo:IAO_0000115 "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." ; oboInOwl:hasExactSynonym "biogenic amine metabolism", "cellular biogenic amine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006576" ; a owl:Class ; rdfs:label "biogenic amine metabolic process" ; rdfs:subClassOf obo:GO_0009308 . obo:GO_0006577 obo:IAO_0000115 "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." ; oboInOwl:hasExactSynonym "betaine metabolic process", "betaine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006577" ; a owl:Class ; rdfs:label "amino-acid betaine metabolic process" ; rdfs:subClassOf obo:GO_0006575, obo:GO_0034641 . obo:GO_0006582 obo:IAO_0000115 "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." ; oboInOwl:hasExactSynonym "melanin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006582" ; a owl:Class ; rdfs:label "melanin metabolic process" ; rdfs:subClassOf obo:GO_0018958, obo:GO_0019748, obo:GO_0042440 . obo:GO_0006586 obo:IAO_0000115 "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." ; oboInOwl:hasBroadSynonym "indolamine metabolic process", "indolamine metabolism" ; oboInOwl:hasExactSynonym "indolalkylamine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006586" ; a owl:Class ; rdfs:label "indolalkylamine metabolic process" ; rdfs:subClassOf obo:GO_0006576, obo:GO_0042430 . obo:GO_0006590 obo:IAO_0000115 "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006590" ; a owl:Class ; rdfs:comment "Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis." ; rdfs:label "thyroid hormone generation" ; rdfs:subClassOf obo:GO_0042403 . obo:GO_0006591 obo:IAO_0000115 "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." ; oboInOwl:hasExactSynonym "ornithine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006591" ; a owl:Class ; rdfs:label "ornithine metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_0006600 obo:IAO_0000115 "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." ; oboInOwl:hasExactSynonym "creatine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006600" ; a owl:Class ; rdfs:label "creatine metabolic process" ; rdfs:subClassOf obo:GO_0006575, obo:GO_0032787 . obo:GO_0006624 obo:IAO_0000115 "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "vacuolar protein maturation", "vacuolar proteolysis" ; oboInOwl:id "GO:0006624" ; a owl:Class ; rdfs:label "vacuolar protein processing" ; rdfs:subClassOf obo:GO_0016485, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005773 ] ) ] . obo:GO_0006629 obo:IAO_0000115 "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." ; oboInOwl:hasDbXref "Wikipedia:Lipid_metabolism" ; oboInOwl:hasExactSynonym "lipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006629" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "lipid metabolic process" ; rdfs:subClassOf obo:GO_0044238, obo:GO_0071704 . obo:GO_0006631 obo:IAO_0000115 "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." ; oboInOwl:hasDbXref "Wikipedia:Fatty_acid_metabolism" ; oboInOwl:hasExactSynonym "fatty acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006631" ; a owl:Class ; rdfs:label "fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0032787, obo:GO_0044255 . obo:GO_0006643 obo:IAO_0000115 "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." ; oboInOwl:hasExactSynonym "membrane lipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006643" ; a owl:Class ; rdfs:label "membrane lipid metabolic process" ; rdfs:subClassOf obo:GO_0044255 . obo:GO_0006664 obo:IAO_0000115 "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." ; oboInOwl:hasExactSynonym "glycolipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006664" ; a owl:Class ; rdfs:label "glycolipid metabolic process" ; rdfs:subClassOf obo:GO_0006643, obo:GO_1903509 . obo:GO_0006665 obo:IAO_0000115 "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." ; oboInOwl:hasExactSynonym "sphingolipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006665" ; a owl:Class ; rdfs:label "sphingolipid metabolic process" ; rdfs:subClassOf obo:GO_0006643, obo:GO_1901564 . obo:GO_0006672 obo:IAO_0000115 "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." ; oboInOwl:hasExactSynonym "ceramide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006672" ; a owl:Class ; rdfs:label "ceramide metabolic process" ; rdfs:subClassOf obo:GO_0006665, obo:GO_0043603 . obo:GO_0006687 obo:IAO_0000115 "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." ; oboInOwl:hasExactSynonym "glycosphingolipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006687" ; a owl:Class ; rdfs:label "glycosphingolipid metabolic process" ; rdfs:subClassOf obo:GO_0006664, obo:GO_0006665 . obo:GO_0006690 obo:IAO_0000115 "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." ; oboInOwl:hasExactSynonym "eicosanoid metabolic process", "eicosanoid metabolism", "icosanoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006690" ; a owl:Class ; rdfs:label "icosanoid metabolic process" ; rdfs:subClassOf obo:GO_0019752 . obo:GO_0006692 obo:IAO_0000115 "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." ; oboInOwl:hasExactSynonym "prostanoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006692" ; a owl:Class ; rdfs:label "prostanoid metabolic process" ; rdfs:subClassOf obo:GO_0006690, obo:GO_0033559 . obo:GO_0006693 obo:IAO_0000115 "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." ; oboInOwl:hasExactSynonym "prostaglandin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006693" ; a owl:Class ; rdfs:label "prostaglandin metabolic process" ; rdfs:subClassOf obo:GO_0006692 . obo:GO_0006694 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." ; oboInOwl:hasDbXref "Wikipedia:Steroid_metabolisms#Steroid_biosynthesis" ; oboInOwl:hasExactSynonym "steroid anabolism", "steroid biosynthesis", "steroid formation", "steroid synthesis", "steroidogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006694" ; a owl:Class ; rdfs:label "steroid biosynthetic process" ; rdfs:subClassOf obo:GO_0008202, obo:GO_0008610, obo:GO_1901362 . obo:GO_0006699 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." ; oboInOwl:hasExactSynonym "bile acid anabolism", "bile acid biosynthesis", "bile acid formation", "bile acid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006699" ; a owl:Class ; rdfs:label "bile acid biosynthetic process" ; rdfs:subClassOf obo:GO_0006694, obo:GO_0008206, obo:GO_0072330, obo:GO_1901617 . obo:GO_0006704 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." ; oboInOwl:hasExactSynonym "glucocorticoid anabolism", "glucocorticoid biosynthesis", "glucocorticoid formation", "glucocorticoid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006704" ; a owl:Class ; rdfs:label "glucocorticoid biosynthetic process" ; rdfs:subClassOf obo:GO_0008211, obo:GO_0120178 . obo:GO_0006705 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." ; oboInOwl:hasExactSynonym "mineralocorticoid anabolism", "mineralocorticoid biosynthesis", "mineralocorticoid formation", "mineralocorticoid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006705" ; a owl:Class ; rdfs:label "mineralocorticoid biosynthetic process" ; rdfs:subClassOf obo:GO_0008212, obo:GO_0042446, obo:GO_0120178 . obo:GO_0006720 obo:IAO_0000115 "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." ; oboInOwl:hasAlternativeId "GO:0016096" ; oboInOwl:hasExactSynonym "isoprenoid metabolism" ; oboInOwl:hasNarrowSynonym "polyisoprenoid metabolic process", "polyisoprenoid metabolism", "polyterpene metabolic process", "polyterpene metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006720" ; a owl:Class ; rdfs:label "isoprenoid metabolic process" ; rdfs:subClassOf obo:GO_0044255 . obo:GO_0006721 obo:IAO_0000115 "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." ; oboInOwl:hasExactSynonym "terpenoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006721" ; a owl:Class ; rdfs:label "terpenoid metabolic process" ; rdfs:subClassOf obo:GO_0006720 . obo:GO_0006725 obo:IAO_0000115 "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." ; oboInOwl:hasExactSynonym "aromatic compound metabolism" ; oboInOwl:hasNarrowSynonym "aromatic hydrocarbon metabolic process", "aromatic hydrocarbon metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006725" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular aromatic compound metabolic process" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0006766 obo:IAO_0000115 "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." ; oboInOwl:hasExactSynonym "vitamin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006766" ; oboInOwl:inSubset go:goslim_candida, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:goslim_yeast ; a owl:Class ; rdfs:label "vitamin metabolic process" ; rdfs:subClassOf obo:GO_0044281 . obo:GO_0006767 obo:IAO_0000115 "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." ; oboInOwl:hasExactSynonym "water-soluble vitamin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006767" ; a owl:Class ; rdfs:label "water-soluble vitamin metabolic process" ; rdfs:subClassOf obo:GO_0006766 . obo:GO_0006775 obo:IAO_0000115 "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." ; oboInOwl:hasExactSynonym "fat-soluble vitamin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006775" ; a owl:Class ; rdfs:label "fat-soluble vitamin metabolic process" ; rdfs:subClassOf obo:GO_0006766 . obo:GO_0006776 obo:IAO_0000115 "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." ; oboInOwl:hasExactSynonym "vitamin A metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006776" ; a owl:Class ; rdfs:label "vitamin A metabolic process" ; rdfs:subClassOf obo:GO_0001523, obo:GO_0006775 . obo:GO_0006778 obo:IAO_0000115 "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "porphyrin metabolic process", "porphyrin metabolism" ; oboInOwl:id "GO:0006778" ; a owl:Class ; rdfs:label "porphyrin-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0033013 . obo:GO_0006779 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "porphyrin anabolism", "porphyrin biosynthesis", "porphyrin biosynthetic process", "porphyrin formation", "porphyrin synthesis" ; oboInOwl:id "GO:0006779" ; a owl:Class ; rdfs:label "porphyrin-containing compound biosynthetic process" ; rdfs:subClassOf obo:GO_0006778, obo:GO_0033014 . obo:GO_0006783 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." ; oboInOwl:hasDbXref "MetaCyc:HEMESYN2-PWY" ; oboInOwl:hasExactSynonym "haem biosynthesis", "haem biosynthetic process", "heme anabolism", "heme biosynthesis", "heme formation", "heme synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006783" ; a owl:Class ; rdfs:label "heme biosynthetic process" ; rdfs:subClassOf obo:GO_0006779, obo:GO_0042168, obo:GO_0046148 . obo:GO_0006790 obo:IAO_0000115 "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." ; oboInOwl:hasDbXref "Wikipedia:Sulfur_metabolism" ; oboInOwl:hasExactSynonym "sulfur metabolism", "sulphur metabolic process", "sulphur metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006790" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:prokaryote_subset ; a owl:Class ; rdfs:label "sulfur compound metabolic process" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0006793 obo:IAO_0000115 "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." ; oboInOwl:hasExactSynonym "phosphorus metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006793" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "phosphorus metabolic process" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0006796 obo:IAO_0000115 "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." ; oboInOwl:hasExactSynonym "phosphate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "phosphate metabolic process" ; oboInOwl:id "GO:0006796" ; a owl:Class ; rdfs:label "phosphate-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0006793 . obo:GO_0006801 obo:IAO_0000115 "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." ; oboInOwl:hasExactSynonym "oxygen free radical metabolic process", "oxygen free radical metabolism", "superoxide free radical metabolic process", "superoxide free radical metabolism", "superoxide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006801" ; a owl:Class ; rdfs:label "superoxide metabolic process" ; rdfs:subClassOf obo:GO_0072593 . obo:GO_0006807 obo:IAO_0000115 "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." ; oboInOwl:hasExactSynonym "nitrogen compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006807" ; oboInOwl:inSubset go:goslim_metagenomics, go:goslim_pir ; a owl:Class ; rdfs:label "nitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0006810 obo:IAO_0000115 "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20292"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-12-13T16:25:32Z" ; oboInOwl:hasAlternativeId "GO:0015457", "GO:0015460", "GO:0044765" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism transport" ; oboInOwl:id "GO:0006810" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport." ; rdfs:label "transport" ; rdfs:subClassOf obo:GO_0051234 . obo:GO_0006811 obo:IAO_0000115 "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." ; oboInOwl:hasBroadSynonym "ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006811" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "monoatomic ion transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0006833 obo:IAO_0000115 "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006833" ; a owl:Class ; rdfs:label "water transport" ; rdfs:subClassOf obo:GO_0042044, obo:GO_0071702 . obo:GO_0006835 obo:IAO_0000115 "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasAlternativeId "GO:0006841" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "sodium:dicarboxylate transport" ; oboInOwl:id "GO:0006835" ; a owl:Class ; rdfs:label "dicarboxylic acid transport" ; rdfs:subClassOf obo:GO_0046942 . obo:GO_0006836 obo:IAO_0000115 "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." ; oboInOwl:hasNarrowSynonym "sodium:neurotransmitter transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006836" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "neurotransmitter transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0006837 obo:IAO_0000115 "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006837" ; a owl:Class ; rdfs:label "serotonin transport" ; rdfs:subClassOf obo:GO_0015844, obo:GO_0015850 . obo:GO_0006858 obo:IAO_0000115 "The transport of substances that occurs outside cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006858" ; a owl:Class ; rdfs:label "extracellular transport" ; rdfs:subClassOf obo:GO_0006810, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006810 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_0006860 obo:IAO_0000115 "The directed extracellular movement of amino acids." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006860" ; a owl:Class ; rdfs:label "extracellular amino acid transport" ; rdfs:subClassOf obo:GO_0006858, obo:GO_0006865 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_0006865 obo:IAO_0000115 "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasAlternativeId "GO:0006866" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006865" ; oboInOwl:inSubset go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "amino acid transport" ; rdfs:subClassOf obo:GO_0046942, obo:GO_0071705 . obo:GO_0006869 obo:IAO_0000115 "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006869" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "lipid transport" ; rdfs:subClassOf obo:GO_0071702, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010876 ] . obo:GO_0006873 obo:IAO_0000115 "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "cellular ion homeostasis" ; oboInOwl:hasExactSynonym "cellular monoatomic ion homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006873" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "intracellular monoatomic ion homeostasis" ; rdfs:subClassOf obo:GO_0050801, obo:GO_0055082 . obo:GO_0006874 obo:IAO_0000115 "A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." ; oboInOwl:hasBroadSynonym "regulation of calcium ion concentration" ; oboInOwl:hasExactSynonym "cellular calcium ion homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006874" ; a owl:Class ; rdfs:label "intracellular calcium ion homeostasis" ; rdfs:subClassOf obo:GO_0030003, obo:GO_0055074 . obo:GO_0006886 obo:IAO_0000115 "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." ; oboInOwl:hasAlternativeId "GO:0032779" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "copper-induced intracellular protein transport" ; oboInOwl:id "GO:0006886" ; oboInOwl:inSubset go:goslim_generic, go:prokaryote_subset ; a owl:Class ; rdfs:label "intracellular protein transport" ; rdfs:subClassOf obo:GO_0015031, obo:GO_0046907, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0008104 ] . obo:GO_0006887 obo:IAO_0000115 "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." ; oboInOwl:hasAlternativeId "GO:0016194", "GO:0016195" ; oboInOwl:hasDbXref "Wikipedia:Exocytosis" ; oboInOwl:hasExactSynonym "vesicle exocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nonselective vesicle exocytosis" ; oboInOwl:id "GO:0006887" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "exocytosis" ; rdfs:subClassOf obo:GO_0016192, obo:GO_0032940, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0099500 ] . obo:GO_0006897 obo:IAO_0000115 "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24907"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/25268"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0016193", "GO:0016196", "GO:0098701" ; oboInOwl:hasDbXref "Wikipedia:Endocytosis" ; oboInOwl:hasExactSynonym "endocytic import into cell", "vesicle endocytosis" ; oboInOwl:hasNarrowSynonym "plasma membrane invagination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nonselective vesicle endocytosis" ; oboInOwl:id "GO:0006897" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "endocytosis" ; rdfs:subClassOf obo:GO_0016192, obo:GO_0098657, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0006900 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0010324 ] . obo:GO_0006900 obo:IAO_0000115 "The evagination of a membrane, resulting in formation of a vesicle." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-19T15:26:17Z" ; oboInOwl:hasAlternativeId "GO:0006902", "GO:1902591" ; oboInOwl:hasExactSynonym "membrane evagination", "vesicle biosynthesis", "vesicle formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nonselective vesicle assembly", "single organism membrane budding", "single-organism membrane budding", "vesicle budding" ; oboInOwl:id "GO:0006900" ; a owl:Class ; rdfs:label "vesicle budding from membrane" ; rdfs:subClassOf obo:GO_0016050, obo:GO_0061024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016192 ] . obo:GO_0006903 obo:IAO_0000115 "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006903" ; a owl:Class ; rdfs:label "vesicle targeting" ; rdfs:subClassOf obo:GO_0009987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016192 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051650 ] . obo:GO_0006906 obo:IAO_0000115 "Fusion of the membrane of a transport vesicle with its target membrane." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006906" ; a owl:Class ; rdfs:label "vesicle fusion" ; rdfs:subClassOf obo:GO_0016050, obo:GO_0090174, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016192 ] . obo:GO_0006909 obo:IAO_0000115 "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24907"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Phagocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006909" ; a owl:Class ; rdfs:label "phagocytosis" ; rdfs:subClassOf obo:GO_0006897 . obo:GO_0006915 obo:IAO_0000115 "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." ; obo:RO_0002161 obo:NCBITaxon_2 ; oboInOwl:hasAlternativeId "GO:0006917", "GO:0008632" ; oboInOwl:hasBroadSynonym "cell suicide", "cellular suicide" ; oboInOwl:hasDbXref "Wikipedia:Apoptosis" ; oboInOwl:hasExactSynonym "apoptotic cell death", "apoptotic programmed cell death", "programmed cell death by apoptosis" ; oboInOwl:hasNarrowSynonym "activation of apoptosis", "apoptosis", "apoptosis signaling", "apoptotic program", "type I programmed cell death" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "apoptosis activator activity", "caspase-dependent programmed cell death", "commitment to apoptosis", "induction of apoptosis", "induction of apoptosis by p53", "signaling (initiator) caspase activity" ; oboInOwl:id "GO:0006915" ; a owl:Class ; rdfs:label "apoptotic process" ; rdfs:subClassOf obo:GO_0012501 . obo:GO_0006921 obo:IAO_0000115 "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." ; oboInOwl:hasBroadSynonym "cellular component disassembly involved in apoptotic process", "disassembly of cell structures" ; oboInOwl:hasNarrowSynonym "cellular component disassembly involved in apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006921" ; a owl:Class ; rdfs:label "cellular component disassembly involved in execution phase of apoptosis" ; rdfs:subClassOf obo:GO_0022411, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0097194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0022411 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0097194 ] ) ] . obo:GO_0006935 obo:IAO_0000115 "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." ; oboInOwl:hasDbXref "Wikipedia:Chemotaxis" ; oboInOwl:hasExactSynonym "taxis in response to chemical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006935" ; a owl:Class ; rdfs:label "chemotaxis" ; rdfs:subClassOf obo:GO_0042330, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042221 ] . obo:GO_0006936 obo:IAO_0000115 "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." ; oboInOwl:hasDbXref "Wikipedia:Muscle_contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006936" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "muscle contraction" ; rdfs:subClassOf obo:GO_0003012 . obo:GO_0006937 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006937" ; a owl:Class ; rdfs:label "regulation of muscle contraction" ; rdfs:subClassOf obo:GO_0090257, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006936 ] ) ] . obo:GO_0006939 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." ; oboInOwl:hasExactSynonym "visceral muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006939" ; a owl:Class ; rdfs:label "smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006936 . obo:GO_0006940 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of smooth muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006940" ; a owl:Class ; rdfs:label "regulation of smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006937, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006939 ] ) ] . obo:GO_0006941 obo:IAO_0000115 "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." ; oboInOwl:hasExactSynonym "sarcomeric muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006941" ; a owl:Class ; rdfs:label "striated muscle contraction" ; rdfs:subClassOf obo:GO_0006936 . obo:GO_0006942 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of striated muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006942" ; a owl:Class ; rdfs:label "regulation of striated muscle contraction" ; rdfs:subClassOf obo:GO_0006937, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006941 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006941 ] ) ] . obo:GO_0006950 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "response to abiotic stress", "response to biotic stress" ; oboInOwl:id "GO:0006950" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to stress" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0006952 obo:IAO_0000115 "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." ; oboInOwl:hasAlternativeId "GO:0002217", "GO:0042829" ; oboInOwl:hasExactSynonym "defence response", "physiological defense response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "antimicrobial peptide activity", "defense/immunity protein activity" ; oboInOwl:id "GO:0006952" ; a owl:Class ; rdfs:label "defense response" ; rdfs:subClassOf obo:GO_0006950 . obo:GO_0006954 obo:IAO_0000115 "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." ; oboInOwl:hasBroadSynonym "inflammation" ; oboInOwl:hasDbXref "Wikipedia:Inflammation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006954" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "inflammatory response" ; rdfs:subClassOf obo:GO_0006952 . obo:GO_0006955 obo:IAO_0000115 "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006955" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "immune response" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0050896 . obo:GO_0006956 obo:IAO_0000115 "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." ; oboInOwl:hasExactSynonym "complement cascade", "complement response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "complement activity" ; oboInOwl:id "GO:0006956" ; a owl:Class ; rdfs:label "complement activation" ; rdfs:subClassOf obo:GO_0002252, obo:GO_0002253, obo:GO_0006959, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0072376 ] . obo:GO_0006959 obo:IAO_0000115 "An immune response mediated through a body fluid." ; oboInOwl:hasDbXref "Wikipedia:Humoral_immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006959" ; a owl:Class ; rdfs:label "humoral immune response" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0006974 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24775"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0034984" ; oboInOwl:hasBroadSynonym "response to DNA damage stimulus" ; oboInOwl:hasExactSynonym "cellular DNA damage response", "cellular response to DNA damage stimulus", "response to genotoxic stress" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0006974" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "DNA damage response" ; rdfs:subClassOf obo:GO_0033554 . obo:GO_0006996 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-19T15:25:51Z" ; oboInOwl:hasAlternativeId "GO:1902589" ; oboInOwl:hasExactSynonym "organelle organisation", "single organism organelle organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "organelle organization and biogenesis", "single-organism organelle organization" ; oboInOwl:id "GO:0006996" ; oboInOwl:inSubset go:goslim_candida, go:goslim_pir ; a owl:Class ; rdfs:label "organelle organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0006997 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." ; oboInOwl:hasAlternativeId "GO:0048287" ; oboInOwl:hasExactSynonym "nuclear organisation", "nuclear organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nuclear morphology", "nuclear organization and biogenesis", "nucleus organization and biogenesis" ; oboInOwl:id "GO:0006997" ; oboInOwl:inSubset go:goslim_candida, go:goslim_drosophila, go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "nucleus organization" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0007005 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." ; oboInOwl:hasExactSynonym "mitochondria organization", "mitochondrion organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mitochondrion organization and biogenesis" ; oboInOwl:id "GO:0007005" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:goslim_yeast ; a owl:Class ; rdfs:label "mitochondrion organization" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0007006 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." ; oboInOwl:hasExactSynonym "mitochondrial membrane organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mitochondrial membrane organization and biogenesis" ; oboInOwl:id "GO:0007006" ; a owl:Class ; rdfs:label "mitochondrial membrane organization" ; rdfs:subClassOf obo:GO_0007005, obo:GO_0061024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0061024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0007009 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." ; oboInOwl:hasExactSynonym "plasma membrane organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "plasma membrane organization and biogenesis" ; oboInOwl:id "GO:0007009" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "plasma membrane organization" ; rdfs:subClassOf obo:GO_0061024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010256 ] . obo:GO_0007010 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." ; oboInOwl:hasExactSynonym "cytoskeleton organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cytoskeletal organization and biogenesis", "cytoskeletal regulator activity", "cytoskeleton organization and biogenesis" ; oboInOwl:id "GO:0007010" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "cytoskeleton organization" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0007017 obo:IAO_0000115 "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19809"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007017" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "microtubule-based process" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0007018 obo:IAO_0000115 "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007018" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic ; a owl:Class ; rdfs:label "microtubule-based movement" ; rdfs:subClassOf obo:GO_0007017 . obo:GO_0007036 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007036" ; a owl:Class ; rdfs:label "vacuolar calcium ion homeostasis" ; rdfs:subClassOf obo:GO_0006874, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0055074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005773 ] ) ] . obo:GO_0007049 obo:IAO_0000115 "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." ; oboInOwl:hasDbXref "Wikipedia:Cell_cycle" ; oboInOwl:hasExactSynonym "cell-division cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007049" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "cell cycle" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0007059 obo:IAO_0000115 "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." ; oboInOwl:hasDbXref "Wikipedia:Chromosome_segregation" ; oboInOwl:hasExactSynonym "chromosome division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chromosome transmission" ; oboInOwl:id "GO:0007059" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "chromosome segregation" ; rdfs:subClassOf obo:GO_0022402 . obo:GO_0007076 obo:IAO_0000115 "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007076" ; a owl:Class ; rdfs:label "mitotic chromosome condensation" ; rdfs:subClassOf obo:GO_0030261, obo:GO_1903047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030261 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_0007088 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mitosis." ; oboInOwl:hasExactSynonym "regulation of mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007088" ; a owl:Class ; rdfs:label "regulation of mitotic nuclear division" ; rdfs:subClassOf obo:GO_0007346, obo:GO_0010564, obo:GO_0051783, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140014 ] ) ] . obo:GO_0007113 obo:IAO_0000115 "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." ; oboInOwl:hasDbXref "Wikipedia:Mitosis#Endomitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "endomitosis" ; oboInOwl:id "GO:0007113" ; a owl:Class ; rdfs:comment "Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins." ; rdfs:label "endomitotic cell cycle" ; rdfs:subClassOf obo:GO_0000278 . obo:GO_0007135 obo:IAO_0000115 "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." ; oboInOwl:hasDbXref "Wikipedia:Meiosis#Meiosis_II" ; oboInOwl:hasExactSynonym "meiosis II nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007135" ; a owl:Class ; rdfs:label "meiosis II" ; rdfs:subClassOf obo:GO_0061983, obo:GO_0140013 . obo:GO_0007140 obo:IAO_0000115 "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." ; oboInOwl:hasBroadSynonym "male nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "male meiosis" ; oboInOwl:id "GO:0007140" ; a owl:Class ; rdfs:label "male meiotic nuclear division" ; rdfs:subClassOf obo:GO_0022412, obo:GO_0140013, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048232 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048232 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0007142 obo:IAO_0000115 "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." ; oboInOwl:hasExactSynonym "male meiosis II nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007142" ; a owl:Class ; rdfs:label "male meiosis II" ; rdfs:subClassOf obo:GO_0007135, obo:GO_0007140 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048232 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0007143 obo:IAO_0000115 "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." ; oboInOwl:hasBroadSynonym "female meiosis", "female meiotic division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007143" ; a owl:Class ; rdfs:comment "Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'." ; rdfs:label "female meiotic nuclear division" ; rdfs:subClassOf obo:GO_0022412, obo:GO_0140013, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007292 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007292 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0007147 obo:IAO_0000115 "The cell cycle process in which the second meiotic division occurs in the female germline." ; oboInOwl:hasExactSynonym "female meiosis II nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007147" ; a owl:Class ; rdfs:label "female meiosis II" ; rdfs:subClassOf obo:GO_0007135, obo:GO_0007143 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007292 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0007154 obo:IAO_0000115 "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." ; oboInOwl:hasDbXref "Wikipedia:Cell_signaling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007154" ; oboInOwl:inSubset go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "cell communication" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0007155 obo:IAO_0000115 "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2014-04-15T15:59:10Z" ; oboInOwl:hasAlternativeId "GO:0098602" ; oboInOwl:hasDbXref "Wikipedia:Cell_adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell adhesion molecule activity", "single organism cell adhesion" ; oboInOwl:id "GO:0007155" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_pombe, go:prokaryote_subset ; a owl:Class ; rdfs:label "cell adhesion" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0007159 obo:IAO_0000115 "The attachment of a leukocyte to another cell via adhesion molecules." ; obo:RO_0002161 obo:NCBITaxon_33090, obo:NCBITaxon_Union_0000023 ; oboInOwl:hasExactSynonym "leukocyte adhesion", "leukocyte cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007159" ; a owl:Class ; rdfs:label "leukocyte cell-cell adhesion" ; rdfs:subClassOf obo:GO_0098609 . obo:GO_0007162 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." ; oboInOwl:hasExactSynonym "down regulation of cell adhesion", "down-regulation of cell adhesion", "downregulation of cell adhesion" ; oboInOwl:hasNarrowSynonym "inhibition of cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell adhesion receptor inhibitor activity" ; oboInOwl:id "GO:0007162" ; a owl:Class ; rdfs:label "negative regulation of cell adhesion" ; rdfs:subClassOf obo:GO_0030155, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007155 ] ) ] . obo:GO_0007165 obo:IAO_0000115 "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." ; oboInOwl:hasAlternativeId "GO:0023014", "GO:0023015", "GO:0023016", "GO:0023033", "GO:0023045" ; oboInOwl:hasDbXref "Wikipedia:Signal_transduction" ; oboInOwl:hasNarrowSynonym "signal transduction by cis-phosphorylation", "signal transduction by conformational transition", "signal transduction by protein phosphorylation", "signal transduction by trans-phosphorylation", "signaling cascade", "signalling cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "signaling pathway", "signalling pathway" ; oboInOwl:id "GO:0007165" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not." ; rdfs:label "signal transduction" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007154 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0023052 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051716 ] . obo:GO_0007166 obo:IAO_0000115 "The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." ; oboInOwl:hasExactSynonym "cell surface receptor linked signal transduction", "cell surface receptor linked signaling pathway", "cell surface receptor linked signalling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007166" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "cell surface receptor signaling pathway" ; rdfs:subClassOf obo:GO_0007165 . obo:GO_0007186 obo:IAO_0000115 "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." ; oboInOwl:hasAlternativeId "GO:0038042" ; oboInOwl:hasExactSynonym "G protein coupled receptor protein signaling pathway", "G protein coupled receptor protein signalling pathway", "G-protein coupled receptor protein signal transduction", "G-protein coupled receptor protein signaling pathway", "G-protein coupled receptor signalling pathway", "G-protein-coupled receptor protein signalling pathway", "GPCR signaling pathway", "GPCR signalling pathway" ; oboInOwl:hasNarrowSynonym "G-protein coupled receptor signaling pathway via GPCR dimer", "dimeric G-protein coupled receptor signaling pathway", "dimeric G-protein coupled receptor signalling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007186" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "G protein-coupled receptor signaling pathway" ; rdfs:subClassOf obo:GO_0007165 . obo:GO_0007267 obo:IAO_0000115 "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." ; oboInOwl:hasExactSynonym "cell-cell signalling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007267" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_plant ; a owl:Class ; rdfs:label "cell-cell signaling" ; rdfs:subClassOf obo:GO_0007154, obo:GO_0023052 . obo:GO_0007268 obo:IAO_0000115 "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." ; oboInOwl:hasBroadSynonym "signal transmission across a synapse", "synaptic transmission" ; oboInOwl:hasDbXref "Wikipedia:Neurotransmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "neurotransmission" ; oboInOwl:id "GO:0007268" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0098916 . obo:GO_0007269 obo:IAO_0000115 "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." ; oboInOwl:hasAlternativeId "GO:0010554" ; oboInOwl:hasExactSynonym "neurotransmitter release", "neurotransmitter secretory pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007269" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." ; rdfs:label "neurotransmitter secretion" ; rdfs:subClassOf obo:GO_0001505, obo:GO_0006836, obo:GO_0051649, obo:GO_0099643, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] . obo:GO_0007271 obo:IAO_0000115 "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." ; oboInOwl:hasExactSynonym "cholinergic synaptic transmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007271" ; a owl:Class ; rdfs:label "synaptic transmission, cholinergic" ; rdfs:subClassOf obo:GO_0007268 . obo:GO_0007272 obo:IAO_0000115 "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ionic insulation of neurons by glial cells" ; oboInOwl:id "GO:0007272" ; a owl:Class ; rdfs:label "ensheathment of neurons" ; rdfs:subClassOf obo:GO_0009987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007399 ] . obo:GO_0007274 obo:IAO_0000115 "The process of synaptic transmission from a neuron to a muscle, across a synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007274" ; a owl:Class ; rdfs:label "neuromuscular synaptic transmission" ; rdfs:subClassOf obo:GO_0007268 . obo:GO_0007275 obo:IAO_0000115 "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21234"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007275" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_chembl, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that this term was 'developmental process'." ; rdfs:label "multicellular organism development" ; rdfs:subClassOf obo:GO_0032501, obo:GO_0048856 . obo:GO_0007276 obo:IAO_0000115 "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." ; obo:RO_0002161 obo:NCBITaxon_Union_0000023 ; oboInOwl:hasAlternativeId "GO:0009552" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gametogenesis" ; oboInOwl:id "GO:0007276" ; a owl:Class ; rdfs:label "gamete generation" ; rdfs:subClassOf obo:GO_0048609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019953 ] . obo:GO_0007281 obo:IAO_0000115 "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." ; oboInOwl:hasExactSynonym "germ-cell development" ; oboInOwl:hasNarrowSynonym "gametogenesis", "primordial germ cell development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007281" ; a owl:Class ; rdfs:label "germ cell development" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0022412, obo:GO_0048468, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007276 ] . obo:GO_0007283 obo:IAO_0000115 "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." ; oboInOwl:hasDbXref "Wikipedia:Spermatogenesis" ; oboInOwl:hasExactSynonym "generation of spermatozoa" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007283" ; a owl:Class ; rdfs:label "spermatogenesis" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0048232 . obo:GO_0007286 obo:IAO_0000115 "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." ; oboInOwl:hasDbXref "Wikipedia:Spermiogenesis" ; oboInOwl:hasExactSynonym "spermatid cell development", "spermiogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007286" ; a owl:Class ; rdfs:label "spermatid development" ; rdfs:subClassOf obo:GO_0007281, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048515 ] . obo:GO_0007288 obo:IAO_0000115 "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007288" ; a owl:Class ; rdfs:label "sperm axoneme assembly" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0022412, obo:GO_0035082, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0120316 ] . obo:GO_0007289 obo:IAO_0000115 "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." ; oboInOwl:hasExactSynonym "spermatid nuclear differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007289" ; a owl:Class ; rdfs:comment "See also the Cell Ontology term 'spermatid ; CL:0000018'." ; rdfs:label "spermatid nucleus differentiation" ; rdfs:subClassOf obo:GO_0006997, obo:GO_0022412, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007286 ] . obo:GO_0007292 obo:IAO_0000115 "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007292" ; a owl:Class ; rdfs:label "female gamete generation" ; rdfs:subClassOf obo:GO_0007276 . obo:GO_0007320 obo:IAO_0000115 "The introduction of semen or sperm into the genital tract of a female." ; oboInOwl:hasDbXref "Wikipedia:Insemination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007320" ; a owl:Class ; rdfs:label "insemination" ; rdfs:subClassOf obo:GO_0044703, obo:GO_0044706, obo:GO_0048609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007620 ] . obo:GO_0007338 obo:IAO_0000115 "The union of male and female gametes to form a zygote." ; obo:RO_0002161 obo:NCBITaxon_58024 ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "zygote biosynthesis", "zygote formation" ; oboInOwl:id "GO:0007338" ; a owl:Class ; rdfs:label "single fertilization" ; rdfs:subClassOf obo:GO_0009566 . obo:GO_0007346 obo:IAO_0000115 "Any process that modulates the rate or extent of progress through the mitotic cell cycle." ; oboInOwl:hasExactSynonym "mitotic cell cycle modulation", "mitotic cell cycle regulation", "modulation of mitotic cell cycle progression", "regulation of mitotic cell cycle progression", "regulation of progression through mitotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mitotic cell cycle regulator" ; oboInOwl:id "GO:0007346" ; a owl:Class ; rdfs:label "regulation of mitotic cell cycle" ; rdfs:subClassOf obo:GO_0051726, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_0007369 obo:IAO_0000115 "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." ; oboInOwl:hasDbXref "Wikipedia:Gastrulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007369" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "gastrulation" ; rdfs:subClassOf obo:GO_0048598, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0001705 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0001706 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0001707 ] . obo:GO_0007389 obo:IAO_0000115 "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pattern biosynthesis", "pattern formation" ; oboInOwl:id "GO:0007389" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "pattern specification process" ; rdfs:subClassOf obo:GO_0032501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0007398 obo:IAO_0000115 "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007398" ; a owl:Class ; rdfs:label "ectoderm development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0007399 obo:IAO_0000115 "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pan-neural process" ; oboInOwl:id "GO:0007399" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "nervous system development" ; rdfs:subClassOf obo:GO_0048731 . obo:GO_0007417 obo:IAO_0000115 "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." ; oboInOwl:hasDbXref "Wikipedia:Neural_development" ; oboInOwl:hasExactSynonym "CNS development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007417" ; a owl:Class ; rdfs:label "central nervous system development" ; rdfs:subClassOf obo:GO_0048731, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007399 ] . obo:GO_0007422 obo:IAO_0000115 "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007422" ; a owl:Class ; rdfs:label "peripheral nervous system development" ; rdfs:subClassOf obo:GO_0048731, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007399 ] . obo:GO_0007492 obo:IAO_0000115 "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007492" ; a owl:Class ; rdfs:label "endoderm development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0007498 obo:IAO_0000115 "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007498" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "mesoderm development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0007548 obo:IAO_0000115 "The establishment of the sex of an organism by physical differentiation." ; oboInOwl:hasDbXref "Wikipedia:Sexual_differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007548" ; a owl:Class ; rdfs:label "sex differentiation" ; rdfs:subClassOf obo:GO_0003006 . obo:GO_0007565 obo:IAO_0000115 "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." ; oboInOwl:hasDbXref "Wikipedia:Gestation" ; oboInOwl:hasExactSynonym "gestation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "carrying of young" ; oboInOwl:id "GO:0007565" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "female pregnancy" ; rdfs:subClassOf obo:GO_0044703, obo:GO_0044706 . obo:GO_0007567 obo:IAO_0000115 "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." ; oboInOwl:hasExactSynonym "giving birth" ; oboInOwl:hasNarrowSynonym "egg laying" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007567" ; a owl:Class ; rdfs:label "parturition" ; rdfs:subClassOf obo:GO_0044703, obo:GO_0044706 . obo:GO_0007585 obo:IAO_0000115 "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." ; oboInOwl:hasBroadSynonym "breathing", "respiration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007585" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "respiratory gaseous exchange by respiratory system" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0007586 obo:IAO_0000115 "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." ; oboInOwl:hasDbXref "Wikipedia:Digestion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007586" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir ; a owl:Class ; rdfs:label "digestion" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0007588 obo:IAO_0000115 "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22368"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Excretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007588" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir ; a owl:Class ; rdfs:label "excretion" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0007589 obo:IAO_0000115 "The controlled release of a fluid by a cell or tissue in an animal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007589" ; a owl:Class ; rdfs:label "body fluid secretion" ; rdfs:subClassOf obo:GO_0046903, obo:GO_0050878 . obo:GO_0007595 obo:IAO_0000115 "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." ; oboInOwl:hasDbXref "Wikipedia:Lactation" ; oboInOwl:hasExactSynonym "milk secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007595" ; a owl:Class ; rdfs:label "lactation" ; rdfs:subClassOf obo:GO_0007589, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030879 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0060156 ] . obo:GO_0007596 obo:IAO_0000115 "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." ; oboInOwl:hasDbXref "Wikipedia:Coagulation" ; oboInOwl:hasExactSynonym "blood clotting" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007596" ; a owl:Class ; rdfs:label "blood coagulation" ; rdfs:subClassOf obo:GO_0007599, obo:GO_0050817, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042060 ] . obo:GO_0007597 obo:IAO_0000115 "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007597" ; a owl:Class ; rdfs:comment "See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'." ; rdfs:label "blood coagulation, intrinsic pathway" ; rdfs:subClassOf obo:GO_0072376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0072378 ] . obo:GO_0007598 obo:IAO_0000115 "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007598" ; a owl:Class ; rdfs:comment "See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'." ; rdfs:label "blood coagulation, extrinsic pathway" ; rdfs:subClassOf obo:GO_0072376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0072378 ] . obo:GO_0007599 obo:IAO_0000115 "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." ; oboInOwl:hasDbXref "Wikipedia:Hemostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007599" ; a owl:Class ; rdfs:label "hemostasis" ; rdfs:subClassOf obo:GO_0050878 . obo:GO_0007600 obo:IAO_0000115 "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." ; oboInOwl:hasDbXref "Wikipedia:Perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007600" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "sensory perception" ; rdfs:subClassOf obo:GO_0050877 . obo:GO_0007601 obo:IAO_0000115 "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." ; oboInOwl:hasDbXref "Wikipedia:Visual_perception" ; oboInOwl:hasExactSynonym "sense of sight", "sensory visual perception", "vision" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007601" ; a owl:Class ; rdfs:label "visual perception" ; rdfs:subClassOf obo:GO_0050953 . obo:GO_0007605 obo:IAO_0000115 "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." ; oboInOwl:hasDbXref "Wikipedia:Hearing_(sense)" ; oboInOwl:hasExactSynonym "hearing", "perception of sound" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007605" ; a owl:Class ; rdfs:label "sensory perception of sound" ; rdfs:subClassOf obo:GO_0050954 . obo:GO_0007606 obo:IAO_0000115 "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." ; oboInOwl:hasExactSynonym "chemosensory perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007606" ; a owl:Class ; rdfs:label "sensory perception of chemical stimulus" ; rdfs:subClassOf obo:GO_0007600 . obo:GO_0007608 obo:IAO_0000115 "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." ; oboInOwl:hasDbXref "Wikipedia:Olfaction" ; oboInOwl:hasExactSynonym "olfaction", "scent perception", "sense of smell", "smell perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007608" ; a owl:Class ; rdfs:label "sensory perception of smell" ; rdfs:subClassOf obo:GO_0007606 . obo:GO_0007610 obo:IAO_0000115 "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-20T14:06:08Z" ; oboInOwl:hasAlternativeId "GO:0023032", "GO:0044708", "GO:0044709" ; oboInOwl:hasDbXref "Wikipedia:Behavior" ; oboInOwl:hasExactSynonym "behavioral response to stimulus", "behaviour", "behavioural response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism behavior" ; oboInOwl:id "GO:0007610" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_agr, go:goslim_flybase_ribbon ; a owl:Class ; rdfs:comment """1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).""" ; rdfs:label "behavior" ; rdfs:subClassOf obo:GO_0032501 ; owl:disjointWith obo:GO_0032502 . obo:GO_0007611 obo:IAO_0000115 "The acquisition and processing of information and/or the storage and retrieval of this information over time." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007611" ; a owl:Class ; rdfs:label "learning or memory" ; rdfs:subClassOf obo:GO_0007610, obo:GO_0050890 . obo:GO_0007613 obo:IAO_0000115 "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." ; oboInOwl:hasDbXref "Wikipedia:Memory" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007613" ; a owl:Class ; rdfs:label "memory" ; rdfs:subClassOf obo:GO_0007611 . obo:GO_0007617 obo:IAO_0000115 "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." ; oboInOwl:hasDbXref "Wikipedia:Mating_behaviour" ; oboInOwl:hasExactSynonym "mating behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007617" ; a owl:Class ; rdfs:label "mating behavior" ; rdfs:subClassOf obo:GO_0019098 . obo:GO_0007620 obo:IAO_0000115 "The act of sexual union between male and female, involving the transfer of sperm." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007620" ; a owl:Class ; rdfs:label "copulation" ; rdfs:subClassOf obo:GO_0007617 . obo:GO_0007622 obo:IAO_0000115 "The specific behavior of an organism that recur with measured regularity." ; oboInOwl:hasExactSynonym "rhythmic behavioral response to stimulus", "rhythmic behaviour", "rhythmic behavioural response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007622" ; a owl:Class ; rdfs:label "rhythmic behavior" ; rdfs:subClassOf obo:GO_0007610 . obo:GO_0007623 obo:IAO_0000115 "Any biological process in an organism that recurs with a regularity of approximately 24 hours." ; oboInOwl:hasAlternativeId "GO:0050895" ; oboInOwl:hasDbXref "Wikipedia:Circadian_rhythm" ; oboInOwl:hasExactSynonym "circadian process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "circadian response", "response to circadian rhythm" ; oboInOwl:id "GO:0007623" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_plant ; a owl:Class ; rdfs:label "circadian rhythm" ; rdfs:subClassOf obo:GO_0048511 . obo:GO_0007626 obo:IAO_0000115 "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." ; oboInOwl:hasExactSynonym "behavior via locomotion", "locomotion in response to stimulus", "locomotory behavioral response to stimulus", "locomotory behaviour", "locomotory behavioural response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007626" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "locomotory behavior" ; rdfs:subClassOf obo:GO_0007610 . obo:GO_0007631 obo:IAO_0000115 "Behavior associated with the intake of food." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/18547"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2011-10-27T03:53:33Z" ; oboInOwl:hasAlternativeId "GO:0044366", "GO:0044367", "GO:0044368", "GO:0044369", "GO:0044370", "GO:0044371", "GO:0044372" ; oboInOwl:hasDbXref "Wikipedia:List_of_feeding_behaviours" ; oboInOwl:hasExactSynonym "behavioral response to food", "behavioural response to food", "feeding behaviour" ; oboInOwl:hasNarrowSynonym "eating", "feeding from phloem of other organism", "feeding from plant phloem", "feeding from tissue of other organism", "feeding from vascular tissue of another organism", "feeding from xylem of other organism", "feeding on blood of other organism", "feeding on or from other organism", "feeding on plant sap", "hematophagy", "injection of substance into other organism during feeding on blood of other organism", "taking of blood meal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0007631" ; a owl:Class ; rdfs:comment "See also the biological process term 'behavior ; GO:0007610'." ; rdfs:label "feeding behavior" ; rdfs:subClassOf obo:GO_0007610 . obo:GO_0008015 obo:IAO_0000115 "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." ; oboInOwl:hasAlternativeId "GO:0070261" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "hemolymph circulation" ; oboInOwl:id "GO:0008015" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "blood circulation" ; rdfs:subClassOf obo:GO_0003013 . obo:GO_0008016 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." ; oboInOwl:hasExactSynonym "regulation of cardiac contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008016" ; a owl:Class ; rdfs:label "regulation of heart contraction" ; rdfs:subClassOf obo:GO_1903522, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060047 ] ) ] . obo:GO_0008104 obo:IAO_0000115 "Any process in which a protein is transported to, or maintained in, a specific location." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0008105", "GO:0016249", "GO:0034613" ; oboInOwl:hasExactSynonym "cellular protein localisation", "cellular protein localization", "protein localisation" ; oboInOwl:hasNarrowSynonym "channel localizer activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "asymmetric protein localisation", "asymmetric protein localization", "establishment and maintenance of asymmetric protein localization", "establishment and maintenance of protein localization" ; oboInOwl:id "GO:0008104" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "protein localization" ; rdfs:subClassOf obo:GO_0070727 . obo:GO_0008150 obo:IAO_0000115 "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24968"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T15:05:24Z" ; oboInOwl:hasAlternativeId "GO:0000004", "GO:0007582", "GO:0044699" ; oboInOwl:hasDbXref "Wikipedia:Biological_process" ; oboInOwl:hasExactSynonym "biological process", "physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single organism process", "single-organism process" ; oboInOwl:id "GO:0008150" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_pombe, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ; rdfs:label "biological_process" . obo:GO_0008152 obo:IAO_0000115 "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-10-17T15:46:40Z" ; oboInOwl:hasAlternativeId "GO:0044236", "GO:0044710" ; oboInOwl:hasDbXref "Wikipedia:Metabolism" ; oboInOwl:hasExactSynonym "metabolism" ; oboInOwl:hasNarrowSynonym "metabolic process resulting in cell growth", "metabolism resulting in cell growth", "multicellular organism metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism metabolic process" ; oboInOwl:id "GO:0008152" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_chembl, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ; rdfs:label "metabolic process" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848, obo:GO_0051179 . obo:GO_0008202 obo:IAO_0000115 "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." ; oboInOwl:hasDbXref "Wikipedia:Steroid_metabolism" ; oboInOwl:hasExactSynonym "steroid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008202" ; a owl:Class ; rdfs:label "steroid metabolic process" ; rdfs:subClassOf obo:GO_0006629, obo:GO_1901360 . obo:GO_0008203 obo:IAO_0000115 "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." ; obo:RO_0002161 obo:NCBITaxon_4895, obo:NCBITaxon_4930 ; oboInOwl:hasExactSynonym "cholesterol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008203" ; a owl:Class ; rdfs:label "cholesterol metabolic process" ; rdfs:subClassOf obo:GO_0016125, obo:GO_1902652 . obo:GO_0008206 obo:IAO_0000115 "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." ; oboInOwl:hasExactSynonym "bile acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008206" ; a owl:Class ; rdfs:label "bile acid metabolic process" ; rdfs:subClassOf obo:GO_0008202, obo:GO_0032787, obo:GO_1901615 . obo:GO_0008211 obo:IAO_0000115 "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." ; oboInOwl:hasExactSynonym "glucocorticoid metabolism", "glucocorticosteroid metabolic process", "glucocorticosteroid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008211" ; a owl:Class ; rdfs:label "glucocorticoid metabolic process" ; rdfs:subClassOf obo:GO_0008202 . obo:GO_0008212 obo:IAO_0000115 "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." ; oboInOwl:hasExactSynonym "mineralocorticoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008212" ; a owl:Class ; rdfs:label "mineralocorticoid metabolic process" ; rdfs:subClassOf obo:GO_0008202, obo:GO_0009987, obo:GO_0042445 . obo:GO_0008217 obo:IAO_0000115 "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." ; oboInOwl:hasDbXref "Wikipedia:Blood_pressure#Regulation" ; oboInOwl:hasExactSynonym "blood pressure regulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "blood pressure homeostasis", "control of blood pressure" ; oboInOwl:id "GO:0008217" ; a owl:Class ; rdfs:label "regulation of blood pressure" ; rdfs:subClassOf obo:GO_0065008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0008015 ] . obo:GO_0008219 obo:IAO_0000115 "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "accidental cell death", "necrosis" ; oboInOwl:id "GO:0008219" ; a owl:Class ; rdfs:comment "This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term." ; rdfs:label "cell death" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0008277 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." ; oboInOwl:hasExactSynonym "regulation of G protein coupled receptor protein signaling pathway", "regulation of G protein coupled receptor protein signalling pathway", "regulation of G-protein coupled receptor protein signaling pathway", "regulation of G-protein coupled receptor protein signalling pathway", "regulation of G-protein-coupled receptor protein signalling pathway", "regulation of GPCR protein signaling pathway", "regulation of GPCR protein signalling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008277" ; a owl:Class ; rdfs:label "regulation of G protein-coupled receptor signaling pathway" ; rdfs:subClassOf obo:GO_0009966, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007186 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007186 ] ) ] . obo:GO_0008283 obo:IAO_0000115 "The multiplication or reproduction of cells, resulting in the expansion of a cell population." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell proliferation" ; oboInOwl:id "GO:0008283" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir ; a owl:Class ; rdfs:comment "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms." ; rdfs:label "cell population proliferation" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0008284 obo:IAO_0000115 "Any process that activates or increases the rate or extent of cell proliferation." ; oboInOwl:hasExactSynonym "up regulation of cell proliferation", "up-regulation of cell proliferation", "upregulation of cell proliferation" ; oboInOwl:hasNarrowSynonym "activation of cell proliferation", "stimulation of cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cell proliferation" ; oboInOwl:id "GO:0008284" ; a owl:Class ; rdfs:label "positive regulation of cell population proliferation" ; rdfs:subClassOf obo:GO_0042127, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008283 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008283 ] ) ] . obo:GO_0008285 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of cell proliferation." ; oboInOwl:hasExactSynonym "down regulation of cell proliferation", "down-regulation of cell proliferation", "downregulation of cell proliferation" ; oboInOwl:hasNarrowSynonym "inhibition of cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cell proliferation" ; oboInOwl:id "GO:0008285" ; a owl:Class ; rdfs:label "negative regulation of cell population proliferation" ; rdfs:subClassOf obo:GO_0042127, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008283 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008283 ] ) ] . obo:GO_0008348 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." ; oboInOwl:hasAlternativeId "GO:0042154", "GO:0042155" ; oboInOwl:hasExactSynonym "attenuation of antimicrobial humoral response", "down regulation of antimicrobial humoral response", "down-regulation of antimicrobial humoral response", "downregulation of antimicrobial humoral response" ; oboInOwl:hasNarrowSynonym "inhibition of antimicrobial humoral response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008348" ; a owl:Class ; rdfs:label "negative regulation of antimicrobial humoral response" ; rdfs:subClassOf obo:GO_0002759, obo:GO_0002832, obo:GO_0002921, obo:GO_0031348, obo:GO_0032102, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019730 ] ) ] . obo:GO_0008366 obo:IAO_0000115 "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." ; oboInOwl:hasAlternativeId "GO:0042553" ; oboInOwl:hasExactSynonym "cellular axon ensheathment" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cellular nerve ensheathment", "nerve ensheathment" ; oboInOwl:id "GO:0008366" ; a owl:Class ; rdfs:label "axon ensheathment" ; rdfs:subClassOf obo:GO_0007272 . obo:GO_0008374 obo:IAO_0000115 "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." ; oboInOwl:hasDbXref "Reactome:R-HSA-1482775", "Reactome:R-HSA-1482781", "Reactome:R-HSA-1482850", "Reactome:R-HSA-1482861", "Reactome:R-HSA-1482867", "Reactome:R-HSA-162683", "Reactome:R-HSA-3238694", "Reactome:R-HSA-422017", "Reactome:R-HSA-422104", "Reactome:R-HSA-5358343", "Reactome:R-HSA-5483229" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0008374" ; a owl:Class ; rdfs:label "O-acyltransferase activity" ; rdfs:subClassOf obo:GO_0016747 . obo:GO_0008482 obo:IAO_0000115 "Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." ; oboInOwl:hasDbXref "EC:1.8.3.1", "KEGG_REACTION:R00533", "MetaCyc:PWY-5326", "MetaCyc:SULFITE-OXIDASE-RXN", "RHEA:24600", "Reactome:R-HSA-1614544" ; oboInOwl:hasExactSynonym "sulphite oxidase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "sulfite:oxygen oxidoreductase activity" ; oboInOwl:id "GO:0008482" ; a owl:Class ; rdfs:comment "Note that this term has a MetaCyc pathway reference as the pathway only has a single step." ; rdfs:label "sulfite oxidase activity" ; rdfs:subClassOf obo:GO_0016670 . obo:GO_0008483 obo:IAO_0000115 "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." ; oboInOwl:hasDbXref "EC:2.6.1.-", "Reactome:R-HSA-1237102" ; oboInOwl:hasExactSynonym "aminotransferase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0008483" ; a owl:Class ; rdfs:label "transaminase activity" ; rdfs:subClassOf obo:GO_0016769 . obo:GO_0008514 obo:IAO_0000115 "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." ; oboInOwl:hasDbXref "Reactome:R-HSA-2142859", "Reactome:R-HSA-561041", "Reactome:R-HSA-9794830" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0008514" ; a owl:Class ; rdfs:label "organic anion transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0022857, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0015711 ] . obo:GO_0008544 obo:IAO_0000115 "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." ; obo:RO_0002161 obo:NCBITaxon_33090 ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "hypodermis development" ; oboInOwl:id "GO:0008544" ; a owl:Class ; rdfs:label "epidermis development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0008610 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." ; oboInOwl:hasExactSynonym "lipid anabolism", "lipid biosynthesis", "lipid formation", "lipid synthesis", "lipogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008610" ; a owl:Class ; rdfs:label "lipid biosynthetic process" ; rdfs:subClassOf obo:GO_0006629, obo:GO_1901576 . obo:GO_0008643 obo:IAO_0000115 "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." ; oboInOwl:hasAlternativeId "GO:0006861", "GO:0008644" ; oboInOwl:hasNarrowSynonym "sugar transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0008643" ; oboInOwl:inSubset go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "carbohydrate transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0008645 obo:IAO_0000115 "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-04-08T10:27:23Z" ; oboInOwl:hasAlternativeId "GO:0008646", "GO:0008647", "GO:0035428" ; oboInOwl:hasNarrowSynonym "high-affinity hexose transport", "low-affinity hexose transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "hexose membrane transport", "hexose transport" ; oboInOwl:id "GO:0008645" ; a owl:Class ; rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes." ; rdfs:label "hexose transmembrane transport" ; rdfs:subClassOf obo:GO_0015749 . obo:GO_0009056 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-10-17T15:52:35Z" ; oboInOwl:hasAlternativeId "GO:0044243", "GO:0044712" ; oboInOwl:hasDbXref "Wikipedia:Catabolism" ; oboInOwl:hasExactSynonym "breakdown", "catabolism", "degradation" ; oboInOwl:hasNarrowSynonym "multicellular organismal catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism catabolic process" ; oboInOwl:id "GO:0009056" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_plant ; a owl:Class ; rdfs:label "catabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0009057 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasAlternativeId "GO:0043285", "GO:0044266" ; oboInOwl:hasExactSynonym "biopolymer catabolic process", "macromolecule breakdown", "macromolecule catabolism", "macromolecule degradation" ; oboInOwl:hasNarrowSynonym "multicellular organismal macromolecule catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cellular macromolecule catabolic process", "cellular macromolecule catabolism", "cellular macromolecule degradation" ; oboInOwl:id "GO:0009057" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "macromolecule catabolic process" ; rdfs:subClassOf obo:GO_0043170, obo:GO_1901575 . obo:GO_0009058 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-10-17T15:52:18Z" ; oboInOwl:hasAlternativeId "GO:0044274", "GO:0044711" ; oboInOwl:hasBroadSynonym "formation" ; oboInOwl:hasDbXref "Wikipedia:Anabolism" ; oboInOwl:hasExactSynonym "anabolism", "biosynthesis", "synthesis" ; oboInOwl:hasNarrowSynonym "multicellular organismal biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism biosynthetic process" ; oboInOwl:id "GO:0009058" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:label "biosynthetic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0009059 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; obo:IAO_0000233 "http://amigo.geneontology.org/amigo/term/GO:0070589"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0043284" ; oboInOwl:hasExactSynonym "biopolymer biosynthetic process", "macromolecule anabolism", "macromolecule biosynthesis", "macromolecule formation", "macromolecule synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009059" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "macromolecule biosynthetic process" ; rdfs:subClassOf obo:GO_0043170, obo:GO_1901576 . obo:GO_0009064 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." ; oboInOwl:hasExactSynonym "glutamine family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009064" ; a owl:Class ; rdfs:label "glutamine family amino acid metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_0009066 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." ; oboInOwl:hasExactSynonym "aspartate family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009066" ; a owl:Class ; rdfs:label "aspartate family amino acid metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_0009069 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." ; oboInOwl:hasExactSynonym "serine family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009069" ; a owl:Class ; rdfs:label "serine family amino acid metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_0009072 obo:IAO_0000115 "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." ; oboInOwl:hasExactSynonym "aromatic amino acid family metabolic process", "aromatic amino acid family metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009072" ; a owl:Class ; rdfs:label "aromatic amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006520, obo:GO_0006725, obo:GO_1901360 . obo:GO_0009081 obo:IAO_0000115 "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." ; oboInOwl:hasExactSynonym "branched chain family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009081" ; a owl:Class ; rdfs:label "branched-chain amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006520 . obo:GO_0009100 obo:IAO_0000115 "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." ; oboInOwl:hasExactSynonym "glycoprotein metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009100" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "glycoprotein metabolic process" ; rdfs:subClassOf obo:GO_0019538, obo:GO_1901135 . obo:GO_0009101 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." ; oboInOwl:hasExactSynonym "glycoprotein anabolism", "glycoprotein biosynthesis", "glycoprotein formation", "glycoprotein synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009101" ; a owl:Class ; rdfs:label "glycoprotein biosynthetic process" ; rdfs:subClassOf obo:GO_0009059, obo:GO_0009100, obo:GO_1901137, obo:GO_1901566 . obo:GO_0009112 obo:IAO_0000115 "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." ; oboInOwl:hasExactSynonym "nucleobase metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009112" ; a owl:Class ; rdfs:label "nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0055086, obo:GO_1901564 . obo:GO_0009235 obo:IAO_0000115 "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." ; oboInOwl:hasExactSynonym "cobalamin metabolism", "vitamin B12 metabolic process", "vitamin B12 metabolism" ; oboInOwl:hasNarrowSynonym "vitamin B12 reduction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009235" ; a owl:Class ; rdfs:label "cobalamin metabolic process" ; rdfs:subClassOf obo:GO_0006767, obo:GO_0033013 . obo:GO_0009250 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." ; oboInOwl:hasExactSynonym "glucan anabolism", "glucan biosynthesis", "glucan formation", "glucan synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009250" ; a owl:Class ; rdfs:label "glucan biosynthetic process" ; rdfs:subClassOf obo:GO_0000271, obo:GO_0044042 . obo:GO_0009251 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." ; oboInOwl:hasExactSynonym "glucan breakdown", "glucan catabolism", "glucan degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009251" ; a owl:Class ; rdfs:label "glucan catabolic process" ; rdfs:subClassOf obo:GO_0000272, obo:GO_0044042 . obo:GO_0009295 obo:IAO_0000115 "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." ; oboInOwl:hasDbXref "Wikipedia:Nucleoid" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0009295" ; a owl:Class ; rdfs:label "nucleoid" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0009306 obo:IAO_0000115 "The controlled release of proteins from a cell." ; oboInOwl:hasAlternativeId "GO:0045166", "GO:0045731" ; oboInOwl:hasNarrowSynonym "glycoprotein secretion", "protein secretion during cell fate commitment", "protein secretion resulting in cell fate commitment" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009306" ; a owl:Class ; rdfs:label "protein secretion" ; rdfs:subClassOf obo:GO_0015031, obo:GO_0032940, obo:GO_0035592 . obo:GO_0009308 obo:IAO_0000115 "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2009-07-15T11:55:44Z" ; oboInOwl:hasAlternativeId "GO:0044106" ; oboInOwl:hasExactSynonym "amine metabolism", "cellular amine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009308" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir ; a owl:Class ; rdfs:label "amine metabolic process" ; rdfs:subClassOf obo:GO_1901564 . obo:GO_0009314 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." ; oboInOwl:hasExactSynonym "response to electromagnetic radiation stimulus", "response to radiation stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009314" ; a owl:Class ; rdfs:comment "Note that 'radiation' refers to electromagnetic radiation of any wavelength." ; rdfs:label "response to radiation" ; rdfs:subClassOf obo:GO_0009628 . obo:GO_0009416 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009416" ; oboInOwl:inSubset go:goslim_plant ; a owl:Class ; rdfs:label "response to light stimulus" ; rdfs:subClassOf obo:GO_0009314 . obo:GO_0009437 obo:IAO_0000115 "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." ; oboInOwl:hasExactSynonym "carnitine metabolism", "vitamin Bt metabolic process", "vitamin Bt metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009437" ; a owl:Class ; rdfs:label "carnitine metabolic process" ; rdfs:subClassOf obo:GO_0006577 . obo:GO_0009438 obo:IAO_0000115 "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." ; oboInOwl:hasDbXref "MetaCyc:METHGLYUT-PWY" ; oboInOwl:hasExactSynonym "methylglyoxal metabolism" ; oboInOwl:hasNarrowSynonym "methylglyoxal bypass", "methylglyoxal pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009438" ; a owl:Class ; rdfs:label "methylglyoxal metabolic process" ; rdfs:subClassOf obo:GO_0006081, obo:GO_0042180 . obo:GO_0009566 obo:IAO_0000115 "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20176"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Fertilisation" ; oboInOwl:hasExactSynonym "syngamy" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009566" ; a owl:Class ; rdfs:label "fertilization" ; rdfs:subClassOf obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019953 ] . obo:GO_0009581 obo:IAO_0000115 "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "perception of external stimulus" ; oboInOwl:id "GO:0009581" ; a owl:Class ; rdfs:label "detection of external stimulus" ; rdfs:subClassOf obo:GO_0009605, obo:GO_0051606 . obo:GO_0009582 obo:IAO_0000115 "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "perception of abiotic stimulus" ; oboInOwl:id "GO:0009582" ; a owl:Class ; rdfs:label "detection of abiotic stimulus" ; rdfs:subClassOf obo:GO_0009628, obo:GO_0051606 . obo:GO_0009583 obo:IAO_0000115 "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "detection of light" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "perception of light" ; oboInOwl:id "GO:0009583" ; a owl:Class ; rdfs:label "detection of light stimulus" ; rdfs:subClassOf obo:GO_0009416, obo:GO_0009581, obo:GO_0009582 . obo:GO_0009584 obo:IAO_0000115 "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "perception of visible light" ; oboInOwl:id "GO:0009584" ; a owl:Class ; rdfs:label "detection of visible light" ; rdfs:subClassOf obo:GO_0009583 . obo:GO_0009593 obo:IAO_0000115 "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." ; oboInOwl:hasExactSynonym "chemoperception", "detection of chemical substance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chemoreception", "perception of chemical stimulus", "perception of chemical substance" ; oboInOwl:id "GO:0009593" ; a owl:Class ; rdfs:label "detection of chemical stimulus" ; rdfs:subClassOf obo:GO_0051606, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042221 ] . obo:GO_0009605 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." ; oboInOwl:hasExactSynonym "response to environmental stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009605" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_drosophila, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to external stimulus" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0009607 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." ; oboInOwl:hasNarrowSynonym "response to biotic stress" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009607" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to biotic stimulus" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0009611 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." ; oboInOwl:hasAlternativeId "GO:0002245" ; oboInOwl:hasExactSynonym "physiological response to wounding" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009611" ; a owl:Class ; rdfs:label "response to wounding" ; rdfs:subClassOf obo:GO_0006950 . obo:GO_0009612 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." ; oboInOwl:hasExactSynonym "mechanical stimulus response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chemi-mechanical coupling" ; oboInOwl:id "GO:0009612" ; a owl:Class ; rdfs:label "response to mechanical stimulus" ; rdfs:subClassOf obo:GO_0009605, obo:GO_0009628 . obo:GO_0009615 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." ; oboInOwl:hasExactSynonym "response to viruses" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009615" ; a owl:Class ; rdfs:label "response to virus" ; rdfs:subClassOf obo:GO_0051707 . obo:GO_0009617 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." ; oboInOwl:hasAlternativeId "GO:0009618", "GO:0009680" ; oboInOwl:hasExactSynonym "response to bacteria" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009617" ; a owl:Class ; rdfs:label "response to bacterium" ; rdfs:subClassOf obo:GO_0051707 . obo:GO_0009628 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/16572"^^xsd:anyURI ; oboInOwl:hasNarrowSynonym "response to abiotic stress" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009628" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_metagenomics, go:goslim_plant ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to abiotic stimulus" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0009636 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." ; oboInOwl:hasNarrowSynonym "detoxification response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "toxin resistance", "toxin susceptibility/resistance" ; oboInOwl:id "GO:0009636" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "response to toxic substance" ; rdfs:subClassOf obo:GO_0042221 . obo:GO_0009653 obo:IAO_0000115 "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." ; oboInOwl:hasBroadSynonym "embryogenesis and morphogenesis" ; oboInOwl:hasDbXref "Wikipedia:Morphogenesis" ; oboInOwl:hasExactSynonym "anatomical structure organization", "morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009653" ; a owl:Class ; rdfs:label "anatomical structure morphogenesis" ; rdfs:subClassOf obo:GO_0032502, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048856 ] . obo:GO_0009790 obo:IAO_0000115 "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." ; oboInOwl:hasAlternativeId "GO:0009795" ; oboInOwl:hasBroadSynonym "embryogenesis and morphogenesis" ; oboInOwl:hasDbXref "Wikipedia:Embryogenesis" ; oboInOwl:hasExactSynonym "embryogenesis", "embryonal development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009790" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_chembl, go:goslim_plant ; a owl:Class ; rdfs:label "embryo development" ; rdfs:subClassOf obo:GO_0007275 . obo:GO_0009791 obo:IAO_0000115 "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009791" ; oboInOwl:inSubset go:goslim_plant ; a owl:Class ; rdfs:label "post-embryonic development" ; rdfs:subClassOf obo:GO_0032501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0009792 obo:IAO_0000115 "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." ; oboInOwl:hasBroadSynonym "embryogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009792" ; a owl:Class ; rdfs:label "embryo development ending in birth or egg hatching" ; rdfs:subClassOf obo:GO_0009790 . obo:GO_0009887 obo:IAO_0000115 "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." ; oboInOwl:hasBroadSynonym "histogenesis and organogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009887" ; a owl:Class ; rdfs:label "animal organ morphogenesis" ; rdfs:subClassOf obo:GO_0009653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048513 ] . obo:GO_0009888 obo:IAO_0000115 "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." ; obo:RO_0002161 obo:NCBITaxon_147554, obo:NCBITaxon_33630, obo:NCBITaxon_33682, obo:NCBITaxon_38254, obo:NCBITaxon_4891 ; oboInOwl:hasBroadSynonym "histogenesis and organogenesis" ; oboInOwl:hasDbXref "Wikipedia:Histogenesis" ; oboInOwl:hasExactSynonym "histogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009888" ; a owl:Class ; rdfs:label "tissue development" ; rdfs:subClassOf obo:GO_0048856 . obo:GO_0009889 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." ; oboInOwl:hasExactSynonym "regulation of anabolism", "regulation of biosynthesis", "regulation of formation", "regulation of synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009889" ; a owl:Class ; rdfs:label "regulation of biosynthetic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009058 ] ) ] . obo:GO_0009890 obo:IAO_0000115 "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." ; oboInOwl:hasExactSynonym "down regulation of biosynthetic process", "down-regulation of biosynthetic process", "downregulation of biosynthetic process", "negative regulation of anabolism", "negative regulation of biosynthesis", "negative regulation of formation", "negative regulation of synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009890" ; a owl:Class ; rdfs:label "negative regulation of biosynthetic process" ; rdfs:subClassOf obo:GO_0009889, obo:GO_0009892, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009058 ] ) ] . obo:GO_0009891 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." ; oboInOwl:hasExactSynonym "positive regulation of anabolism", "positive regulation of biosynthesis", "positive regulation of formation", "positive regulation of synthesis", "up regulation of biosynthetic process", "up-regulation of biosynthetic process", "upregulation of biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of biosynthetic process", "stimulation of biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009891" ; a owl:Class ; rdfs:label "positive regulation of biosynthetic process" ; rdfs:subClassOf obo:GO_0009889, obo:GO_0009893, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009058 ] ) ] . obo:GO_0009892 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." ; oboInOwl:hasAlternativeId "GO:0044252" ; oboInOwl:hasExactSynonym "down regulation of metabolic process", "down-regulation of metabolic process", "downregulation of metabolic process", "negative regulation of metabolism", "negative regulation of organismal metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of metabolic process", "inhibition of organismal metabolic process", "negative regulation of multicellular organismal metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009892" ; a owl:Class ; rdfs:label "negative regulation of metabolic process" ; rdfs:subClassOf obo:GO_0019222, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008152 ] ) ] . obo:GO_0009893 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." ; oboInOwl:hasAlternativeId "GO:0044253" ; oboInOwl:hasExactSynonym "positive regulation of metabolism", "up regulation of metabolic process", "up-regulation of metabolic process", "upregulation of metabolic process" ; oboInOwl:hasNarrowSynonym "activation of metabolic process", "positive regulation of multicellular organismal metabolic process", "positive regulation of organismal metabolism", "stimulation of metabolic process", "stimulation of organismal metabolic process", "up-regulation of organismal metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009893" ; a owl:Class ; rdfs:label "positive regulation of metabolic process" ; rdfs:subClassOf obo:GO_0019222, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008152 ] ) ] . obo:GO_0009894 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." ; oboInOwl:hasExactSynonym "regulation of breakdown", "regulation of catabolism", "regulation of degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009894" ; a owl:Class ; rdfs:label "regulation of catabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009056 ] ) ] . obo:GO_0009895 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." ; oboInOwl:hasExactSynonym "down regulation of catabolic process", "down-regulation of catabolic process", "downregulation of catabolic process", "negative regulation of breakdown", "negative regulation of catabolism", "negative regulation of degradation" ; oboInOwl:hasNarrowSynonym "inhibition of catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009895" ; a owl:Class ; rdfs:label "negative regulation of catabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0009894, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009056 ] ) ] . obo:GO_0009896 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." ; oboInOwl:hasExactSynonym "positive regulation of breakdown", "positive regulation of catabolism", "positive regulation of degradation", "up regulation of catabolic process", "up-regulation of catabolic process", "upregulation of catabolic process" ; oboInOwl:hasNarrowSynonym "activation of catabolic process", "stimulation of catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009896" ; a owl:Class ; rdfs:label "positive regulation of catabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0009894, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009056 ] ) ] . obo:GO_0009913 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." ; oboInOwl:hasAlternativeId "GO:0043355" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "hypodermal cell differentiation" ; oboInOwl:id "GO:0009913" ; a owl:Class ; rdfs:label "epidermal cell differentiation" ; rdfs:subClassOf obo:GO_0030855, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0008544 ] . obo:GO_0009914 obo:IAO_0000115 "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009914" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "hormone transport" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0010817 . obo:GO_0009966 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of signal transduction." ; oboInOwl:hasAlternativeId "GO:0035466" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of signaling pathway", "regulation of signalling pathway" ; oboInOwl:id "GO:0009966" ; a owl:Class ; rdfs:label "regulation of signal transduction" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0023051, obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007165 ] ) ] . obo:GO_0009967 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of signal transduction." ; oboInOwl:hasAlternativeId "GO:0035468" ; oboInOwl:hasExactSynonym "up regulation of signal transduction", "up-regulation of signal transduction", "upregulation of signal transduction" ; oboInOwl:hasNarrowSynonym "activation of signal transduction", "stimulation of signal transduction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of signaling pathway", "positive regulation of signalling pathway" ; oboInOwl:id "GO:0009967" ; a owl:Class ; rdfs:label "positive regulation of signal transduction" ; rdfs:subClassOf obo:GO_0009966, obo:GO_0010647, obo:GO_0023056, obo:GO_0048584, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007165 ] ) ] . obo:GO_0009968 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." ; oboInOwl:hasAlternativeId "GO:0035467" ; oboInOwl:hasExactSynonym "down regulation of signal transduction", "down-regulation of signal transduction", "downregulation of signal transduction" ; oboInOwl:hasNarrowSynonym "inhibition of signal transduction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of signaling pathway", "negative regulation of signalling pathway" ; oboInOwl:id "GO:0009968" ; a owl:Class ; rdfs:label "negative regulation of signal transduction" ; rdfs:subClassOf obo:GO_0009966, obo:GO_0010648, obo:GO_0023057, obo:GO_0048585, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007165 ] ) ] . obo:GO_0009987 obo:IAO_0000115 "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-12-11T16:56:55Z" ; oboInOwl:hasAlternativeId "GO:0008151", "GO:0044763", "GO:0050875" ; oboInOwl:hasExactSynonym "cell physiology", "cellular physiological process" ; oboInOwl:hasNarrowSynonym "cell growth and/or maintenance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism cellular process" ; oboInOwl:id "GO:0009987" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_plant ; a owl:Class ; rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ; rdfs:label "cellular process" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0009991 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0009991" ; a owl:Class ; rdfs:label "response to extracellular stimulus" ; rdfs:subClassOf obo:GO_0009605 . obo:GO_0010001 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." ; oboInOwl:hasAlternativeId "GO:0007404", "GO:0043360" ; oboInOwl:hasExactSynonym "glia cell differentiation", "neuroglia differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010001" ; a owl:Class ; rdfs:label "glial cell differentiation" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042063 ] . obo:GO_0010032 obo:IAO_0000115 "Compaction of chromatin structure prior to meiosis in eukaryotic cells." ; oboInOwl:hasExactSynonym "chromosome condensation involved in meiotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010032" ; a owl:Class ; rdfs:label "meiotic chromosome condensation" ; rdfs:subClassOf obo:GO_0030261, obo:GO_0070192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030261 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0010033 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." ; oboInOwl:hasAlternativeId "GO:1990367" ; oboInOwl:hasNarrowSynonym "process resulting in tolerance to organic substance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010033" ; a owl:Class ; rdfs:label "response to organic substance" ; rdfs:subClassOf obo:GO_0042221 . obo:GO_0010256 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." ; oboInOwl:hasExactSynonym "endomembrane organization", "endomembrane system organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010256" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "endomembrane system organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0010324 obo:IAO_0000115 "The infolding of a membrane." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-02T13:58:34Z" ; oboInOwl:hasAlternativeId "GO:1902534" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism membrane invagination" ; oboInOwl:id "GO:0010324" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "membrane invagination" ; rdfs:subClassOf obo:GO_0061024 . obo:GO_0010463 obo:IAO_0000115 "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010463" ; a owl:Class ; rdfs:label "mesenchymal cell proliferation" ; rdfs:subClassOf obo:GO_0008283 . obo:GO_0010464 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010464" ; a owl:Class ; rdfs:label "regulation of mesenchymal cell proliferation" ; rdfs:subClassOf obo:GO_0042127, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010463 ] ) ] . obo:GO_0010467 obo:IAO_0000115 "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22557"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Gene_expression" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010467" ; oboInOwl:inSubset go:goslim_flybase_ribbon ; a owl:Class ; rdfs:label "gene expression" ; rdfs:subClassOf obo:GO_0043170 . obo:GO_0010468 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22557"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Regulation_of_gene_expression" ; oboInOwl:hasNarrowSynonym "regulation of protein expression" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gene regulation", "regulation of gene product expression" ; oboInOwl:id "GO:0010468" ; a owl:Class ; rdfs:comment "This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation." ; rdfs:label "regulation of gene expression" ; rdfs:subClassOf obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010467 ] ) ] . obo:GO_0010469 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." ; oboInOwl:hasBroadSynonym "regulation of receptor activity" ; oboInOwl:hasExactSynonym "regulation of signalling receptor activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010469" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of signaling receptor activity" ; rdfs:subClassOf obo:GO_0009966, obo:GO_0065009, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0038023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0038023 ] ) ] . obo:GO_0010470 obo:IAO_0000115 "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010470" ; a owl:Class ; rdfs:label "regulation of gastrulation" ; rdfs:subClassOf obo:GO_0022603, obo:GO_0045995, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007369 ] ) ] . obo:GO_0010543 obo:IAO_0000115 "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010543" ; a owl:Class ; rdfs:label "regulation of platelet activation" ; rdfs:subClassOf obo:GO_0050865, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030168 ] ) ] . obo:GO_0010544 obo:IAO_0000115 "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010544" ; a owl:Class ; rdfs:label "negative regulation of platelet activation" ; rdfs:subClassOf obo:GO_0010543, obo:GO_0030195, obo:GO_0050866, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030168 ] ) ] . obo:GO_0010556 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010556" ; a owl:Class ; rdfs:label "regulation of macromolecule biosynthetic process" ; rdfs:subClassOf obo:GO_0009889, obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009059 ] ) ] . obo:GO_0010557 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010557" ; a owl:Class ; rdfs:label "positive regulation of macromolecule biosynthetic process" ; rdfs:subClassOf obo:GO_0009891, obo:GO_0010556, obo:GO_0010604, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009059 ] ) ] . obo:GO_0010558 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010558" ; a owl:Class ; rdfs:label "negative regulation of macromolecule biosynthetic process" ; rdfs:subClassOf obo:GO_0009890, obo:GO_0010556, obo:GO_0010605, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009059 ] ) ] . obo:GO_0010559 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010559" ; a owl:Class ; rdfs:label "regulation of glycoprotein biosynthetic process" ; rdfs:subClassOf obo:GO_0010556, obo:GO_1903018, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009101 ] ) ] . obo:GO_0010560 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010560" ; a owl:Class ; rdfs:label "positive regulation of glycoprotein biosynthetic process" ; rdfs:subClassOf obo:GO_0010557, obo:GO_0010559, obo:GO_1903020, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009101 ] ) ] . obo:GO_0010561 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010561" ; a owl:Class ; rdfs:label "negative regulation of glycoprotein biosynthetic process" ; rdfs:subClassOf obo:GO_0010558, obo:GO_0010559, obo:GO_1903019, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009101 ] ) ] . obo:GO_0010562 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010562" ; a owl:Class ; rdfs:label "positive regulation of phosphorus metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0051174, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006793 ] ) ] . obo:GO_0010563 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010563" ; a owl:Class ; rdfs:label "negative regulation of phosphorus metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0051174, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006793 ] ) ] . obo:GO_0010564 obo:IAO_0000115 "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010564" ; a owl:Class ; rdfs:label "regulation of cell cycle process" ; rdfs:subClassOf obo:GO_0051726, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022402 ] ) ] . obo:GO_0010565 obo:IAO_0000115 "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010565" ; a owl:Class ; rdfs:label "regulation of cellular ketone metabolic process" ; rdfs:subClassOf obo:GO_0031323, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042180 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042180 ] ) ] . obo:GO_0010567 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010567" ; a owl:Class ; rdfs:label "regulation of ketone catabolic process" ; rdfs:subClassOf obo:GO_0010565, obo:GO_0031329, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042182 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042182 ] ) ] . obo:GO_0010572 obo:IAO_0000115 "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010572" ; a owl:Class ; rdfs:label "positive regulation of platelet activation" ; rdfs:subClassOf obo:GO_0010543, obo:GO_0050867, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030168 ] ) ] . obo:GO_0010604 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010604" ; a owl:Class ; rdfs:label "positive regulation of macromolecule metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043170 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043170 ] ) ] . obo:GO_0010605 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010605" ; a owl:Class ; rdfs:label "negative regulation of macromolecule metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043170 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043170 ] ) ] . obo:GO_0010608 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." ; oboInOwl:hasExactSynonym "posttranscriptional regulation of gene expression" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010608" ; a owl:Class ; rdfs:label "post-transcriptional regulation of gene expression" ; rdfs:subClassOf obo:GO_0010468 . obo:GO_0010623 obo:IAO_0000115 "The activation of endogenous cellular processes that result in the death of a cell as part of its development." ; oboInOwl:hasBroadSynonym "developmental programmed cell death", "programmed cell death involved in development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010623" ; a owl:Class ; rdfs:comment "This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure." ; rdfs:label "programmed cell death involved in cell development" ; rdfs:subClassOf obo:GO_0012501, obo:GO_0048869, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0012501 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048468 ] ) ] . obo:GO_0010628 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22557"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010628" ; a owl:Class ; rdfs:label "positive regulation of gene expression" ; rdfs:subClassOf obo:GO_0010468, obo:GO_0010604, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010467 ] ) ] . obo:GO_0010629 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22557"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gene silencing" ; oboInOwl:id "GO:0010629" ; a owl:Class ; rdfs:comment "This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation." ; rdfs:label "negative regulation of gene expression" ; rdfs:subClassOf obo:GO_0010468, obo:GO_0010605, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010467 ] ) ] . obo:GO_0010638 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." ; oboInOwl:hasExactSynonym "positive regulation of organelle organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of organelle organization and biogenesis" ; oboInOwl:id "GO:0010638" ; a owl:Class ; rdfs:label "positive regulation of organelle organization" ; rdfs:subClassOf obo:GO_0033043, obo:GO_0051130, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006996 ] ) ] . obo:GO_0010639 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." ; oboInOwl:hasExactSynonym "negative regulation of organelle organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of organelle organization and biogenesis" ; oboInOwl:id "GO:0010639" ; a owl:Class ; rdfs:label "negative regulation of organelle organization" ; rdfs:subClassOf obo:GO_0033043, obo:GO_0051129, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006996 ] ) ] . obo:GO_0010646 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010646" ; a owl:Class ; rdfs:label "regulation of cell communication" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007154 ] ) ] . obo:GO_0010647 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010647" ; a owl:Class ; rdfs:label "positive regulation of cell communication" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007154 ] ) ] . obo:GO_0010648 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010648" ; a owl:Class ; rdfs:label "negative regulation of cell communication" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007154 ] ) ] . obo:GO_0010692 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010692" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of alkaline phosphatase activity" ; rdfs:subClassOf obo:GO_0010921, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0004035 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0004035 ] ) ] . obo:GO_0010693 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010693" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of alkaline phosphatase activity" ; rdfs:subClassOf obo:GO_0010692, obo:GO_0010923, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0004035 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0004035 ] ) ] . obo:GO_0010694 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010694" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of alkaline phosphatase activity" ; rdfs:subClassOf obo:GO_0010692, obo:GO_0010922, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0004035 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0004035 ] ) ] . obo:GO_0010700 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010700" ; a owl:Class ; rdfs:label "negative regulation of norepinephrine secretion" ; rdfs:subClassOf obo:GO_0014061, obo:GO_0033604, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:GO_0010701 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010701" ; a owl:Class ; rdfs:label "positive regulation of norepinephrine secretion" ; rdfs:subClassOf obo:GO_0014061, obo:GO_0033605, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:GO_0010720 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010720" ; a owl:Class ; rdfs:label "positive regulation of cell development" ; rdfs:subClassOf obo:GO_0045597, obo:GO_0060284, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048468 ] ) ] . obo:GO_0010721 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010721" ; a owl:Class ; rdfs:label "negative regulation of cell development" ; rdfs:subClassOf obo:GO_0045596, obo:GO_0060284, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048468 ] ) ] . obo:GO_0010817 obo:IAO_0000115 "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010817" ; a owl:Class ; rdfs:label "regulation of hormone levels" ; rdfs:subClassOf obo:GO_0065008 . obo:GO_0010821 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." ; oboInOwl:hasExactSynonym "regulation of mitochondrion organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010821" ; a owl:Class ; rdfs:label "regulation of mitochondrion organization" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007005 ] ) ] . obo:GO_0010822 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." ; oboInOwl:hasExactSynonym "positive regulation of mitochondrion organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010822" ; a owl:Class ; rdfs:label "positive regulation of mitochondrion organization" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0010821, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007005 ] ) ] . obo:GO_0010823 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." ; oboInOwl:hasExactSynonym "negative regulation of mitochondrion organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010823" ; a owl:Class ; rdfs:label "negative regulation of mitochondrion organization" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0010821, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007005 ] ) ] . obo:GO_0010827 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of glucose transport" ; oboInOwl:id "GO:0010827" ; a owl:Class ; rdfs:label "regulation of glucose transmembrane transport" ; rdfs:subClassOf obo:GO_0034762, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1904659 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1904659 ] ) ] . obo:GO_0010828 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of glucose transport" ; oboInOwl:id "GO:0010828" ; a owl:Class ; rdfs:label "positive regulation of glucose transmembrane transport" ; rdfs:subClassOf obo:GO_0010827, obo:GO_0034764, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1904659 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1904659 ] ) ] . obo:GO_0010829 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of glucose transport" ; oboInOwl:id "GO:0010829" ; a owl:Class ; rdfs:label "negative regulation of glucose transmembrane transport" ; rdfs:subClassOf obo:GO_0010827, obo:GO_0034763, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1904659 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1904659 ] ) ] . obo:GO_0010876 obo:IAO_0000115 "Any process in which a lipid is transported to, or maintained in, a specific location." ; oboInOwl:hasExactSynonym "lipid localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010876" ; a owl:Class ; rdfs:label "lipid localization" ; rdfs:subClassOf obo:GO_0033036 . obo:GO_0010892 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010892" ; a owl:Class ; rdfs:label "positive regulation of mitochondrial translation in response to stress" ; rdfs:subClassOf obo:GO_0032056, obo:GO_0070131 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0033554 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032543 ] ) ] . obo:GO_0010893 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010893" ; a owl:Class ; rdfs:label "positive regulation of steroid biosynthetic process" ; rdfs:subClassOf obo:GO_0045940, obo:GO_0046889, obo:GO_0050810, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006694 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006694 ] ) ] . obo:GO_0010894 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010894" ; a owl:Class ; rdfs:label "negative regulation of steroid biosynthetic process" ; rdfs:subClassOf obo:GO_0045939, obo:GO_0050810, obo:GO_0051055, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006694 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006694 ] ) ] . obo:GO_0010906 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." ; oboInOwl:hasExactSynonym "regulation of glucose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010906" ; a owl:Class ; rdfs:label "regulation of glucose metabolic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006006 ] ) ] . obo:GO_0010907 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." ; oboInOwl:hasExactSynonym "positive regulation of glucose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010907" ; a owl:Class ; rdfs:label "positive regulation of glucose metabolic process" ; rdfs:subClassOf obo:GO_0010906, obo:GO_0045913, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006006 ] ) ] . obo:GO_0010911 obo:IAO_0000115 "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010911" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of isomerase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016853 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016853 ] ) ] . obo:GO_0010912 obo:IAO_0000115 "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010912" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of isomerase activity" ; rdfs:subClassOf obo:GO_0010911, obo:GO_0043085, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016853 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016853 ] ) ] . obo:GO_0010921 obo:IAO_0000115 "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010921" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of phosphatase activity" ; rdfs:subClassOf obo:GO_0035303, obo:GO_0051336, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016791 ] ) ] . obo:GO_0010922 obo:IAO_0000115 "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010922" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of phosphatase activity" ; rdfs:subClassOf obo:GO_0010921, obo:GO_0035306, obo:GO_0051345, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016791 ] ) ] . obo:GO_0010923 obo:IAO_0000115 "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010923" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of phosphatase activity" ; rdfs:subClassOf obo:GO_0010921, obo:GO_0035305, obo:GO_0051346, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016791 ] ) ] . obo:GO_0010927 obo:IAO_0000115 "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010927" ; a owl:Class ; rdfs:label "cellular component assembly involved in morphogenesis" ; rdfs:subClassOf obo:GO_0022607, obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032989 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0022607 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] ) ] . obo:GO_0010948 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-04-27T09:53:22Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010948" ; a owl:Class ; rdfs:label "negative regulation of cell cycle process" ; rdfs:subClassOf obo:GO_0010564, obo:GO_0045786, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022402 ] ) ] . obo:GO_0010954 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-04-27T12:09:13Z" ; oboInOwl:hasExactSynonym "positive regulation of protein maturation by peptide bond cleavage" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010954" ; a owl:Class ; rdfs:label "positive regulation of protein processing" ; rdfs:subClassOf obo:GO_0045862, obo:GO_0070613, obo:GO_1903319, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:GO_0010955 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-04-27T12:10:19Z" ; oboInOwl:hasExactSynonym "negative regulation of protein maturation by peptide bond cleavage" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010955" ; a owl:Class ; rdfs:label "negative regulation of protein processing" ; rdfs:subClassOf obo:GO_0045861, obo:GO_0070613, obo:GO_1903318, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:GO_0010960 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-05-06T11:47:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010960" ; a owl:Class ; rdfs:label "magnesium ion homeostasis" ; rdfs:subClassOf obo:GO_0055080, obo:GO_0098771 . obo:GO_0010962 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-05-11T12:17:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010962" ; a owl:Class ; rdfs:label "regulation of glucan biosynthetic process" ; rdfs:subClassOf obo:GO_0032885, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009250 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009250 ] ) ] . obo:GO_0010970 obo:IAO_0000115 "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-05-27T10:56:08Z" ; oboInOwl:hasBroadSynonym "microtubule-based transport" ; oboInOwl:hasExactSynonym "establishment of localization by movement along microtubule", "movement along microtubule" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0010970" ; a owl:Class ; rdfs:label "transport along microtubule" ; rdfs:subClassOf obo:GO_0007018, obo:GO_0030705, obo:GO_0099111 . obo:GO_0012501 obo:IAO_0000115 "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24835"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0016244" ; oboInOwl:hasBroadSynonym "regulated cell death" ; oboInOwl:hasDbXref "Wikipedia:Programmed_cell_death" ; oboInOwl:hasNarrowSynonym "caspase-independent cell death", "non-apoptotic programmed cell death", "nonapoptotic programmed cell death" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "PCD", "RCD", "caspase-independent apoptosis" ; oboInOwl:id "GO:0012501" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_mouse, go:goslim_plant, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children." ; rdfs:label "programmed cell death" ; rdfs:subClassOf obo:GO_0008219 . obo:GO_0012505 obo:IAO_0000115 "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." ; oboInOwl:hasDbXref "Wikipedia:Endomembrane_system" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0012505" ; oboInOwl:inSubset go:goslim_candida, go:goslim_flybase_ribbon, go:goslim_yeast ; a owl:Class ; rdfs:label "endomembrane system" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005773 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005886 ] . obo:GO_0012506 obo:IAO_0000115 "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1153182838" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0012506" ; a owl:Class ; rdfs:label "vesicle membrane" ; rdfs:subClassOf obo:GO_0031090, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031982 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031982 ] ) ] . obo:GO_0014003 obo:IAO_0000115 "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." ; oboInOwl:hasExactSynonym "oligodendrocyte cell development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014003" ; a owl:Class ; rdfs:label "oligodendrocyte development" ; rdfs:subClassOf obo:GO_0021782, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048709 ] . obo:GO_0014013 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014013" ; a owl:Class ; rdfs:label "regulation of gliogenesis" ; rdfs:subClassOf obo:GO_0050767, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042063 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042063 ] ) ] . obo:GO_0014014 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." ; oboInOwl:hasExactSynonym "down regulation of gliogenesis", "down-regulation of gliogenesis", "downregulation of gliogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of gliogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014014" ; a owl:Class ; rdfs:label "negative regulation of gliogenesis" ; rdfs:subClassOf obo:GO_0014013, obo:GO_0050768, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042063 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042063 ] ) ] . obo:GO_0014015 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." ; oboInOwl:hasExactSynonym "up regulation of gliogenesis", "up-regulation of gliogenesis", "upregulation of gliogenesis" ; oboInOwl:hasNarrowSynonym "activation of gliogenesis", "stimulation of gliogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014015" ; a owl:Class ; rdfs:label "positive regulation of gliogenesis" ; rdfs:subClassOf obo:GO_0014013, obo:GO_0050769, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042063 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042063 ] ) ] . obo:GO_0014020 obo:IAO_0000115 "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." ; oboInOwl:hasAlternativeId "GO:0014024" ; oboInOwl:hasExactSynonym "primary neural tube morphogenesis", "primary neurulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "neural rod cavitation" ; oboInOwl:id "GO:0014020" ; a owl:Class ; rdfs:label "primary neural tube formation" ; rdfs:subClassOf obo:GO_0001838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001841 ] . obo:GO_0014037 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014037" ; a owl:Class ; rdfs:label "Schwann cell differentiation" ; rdfs:subClassOf obo:GO_0010001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007422 ] . obo:GO_0014038 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014038" ; a owl:Class ; rdfs:label "regulation of Schwann cell differentiation" ; rdfs:subClassOf obo:GO_0045685, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014037 ] ) ] . obo:GO_0014039 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of Schwann cell differentiation", "down-regulation of Schwann cell differentiation", "downregulation of Schwann cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of Schwann cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014039" ; a owl:Class ; rdfs:label "negative regulation of Schwann cell differentiation" ; rdfs:subClassOf obo:GO_0014038, obo:GO_0045686, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014037 ] ) ] . obo:GO_0014040 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." ; oboInOwl:hasExactSynonym "up regulation of Schwann cell differentiation", "up-regulation of Schwann cell differentiation", "upregulation of Schwann cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of Schwann cell differentiation", "stimulation of Schwann cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014040" ; a owl:Class ; rdfs:label "positive regulation of Schwann cell differentiation" ; rdfs:subClassOf obo:GO_0014038, obo:GO_0045687, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014037 ] ) ] . obo:GO_0014044 obo:IAO_0000115 "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014044" ; a owl:Class ; rdfs:label "Schwann cell development" ; rdfs:subClassOf obo:GO_0021782, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014037 ] . obo:GO_0014046 obo:IAO_0000115 "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014046" ; a owl:Class ; rdfs:label "dopamine secretion" ; rdfs:subClassOf obo:GO_0015872, obo:GO_0023061, obo:GO_0050432 . obo:GO_0014047 obo:IAO_0000115 "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014047" ; a owl:Class ; rdfs:label "glutamate secretion" ; rdfs:subClassOf obo:GO_0006835, obo:GO_0015800, obo:GO_0032940, obo:GO_0042886 . obo:GO_0014048 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014048" ; a owl:Class ; rdfs:label "regulation of glutamate secretion" ; rdfs:subClassOf obo:GO_0051955, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014047 ] ) ] . obo:GO_0014049 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." ; oboInOwl:hasExactSynonym "up regulation of glutamate secretion", "up-regulation of glutamate secretion", "upregulation of glutamate secretion" ; oboInOwl:hasNarrowSynonym "activation of glutamate secretion", "stimulation of glutamate secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014049" ; a owl:Class ; rdfs:label "positive regulation of glutamate secretion" ; rdfs:subClassOf obo:GO_0014048, obo:GO_0051957, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014047 ] ) ] . obo:GO_0014050 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." ; oboInOwl:hasExactSynonym "down regulation of glutamate secretion", "down-regulation of glutamate secretion", "downregulation of glutamate secretion" ; oboInOwl:hasNarrowSynonym "inhibition of glutamate secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014050" ; a owl:Class ; rdfs:label "negative regulation of glutamate secretion" ; rdfs:subClassOf obo:GO_0014048, obo:GO_0051956, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014047 ] ) ] . obo:GO_0014051 obo:IAO_0000115 "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." ; oboInOwl:hasExactSynonym "GABA secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014051" ; a owl:Class ; rdfs:label "gamma-aminobutyric acid secretion" ; rdfs:subClassOf obo:GO_0015812, obo:GO_0046717 . obo:GO_0014052 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." ; oboInOwl:hasExactSynonym "regulation of GABA secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014052" ; a owl:Class ; rdfs:label "regulation of gamma-aminobutyric acid secretion" ; rdfs:subClassOf obo:GO_0051046, obo:GO_0051955, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014051 ] ) ] . obo:GO_0014053 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." ; oboInOwl:hasExactSynonym "down regulation of gamma-aminobutyric acid secretion", "down-regulation of gamma-aminobutyric acid secretion", "downregulation of gamma-aminobutyric acid secretion", "negative regulation of GABA secretion" ; oboInOwl:hasNarrowSynonym "inhibition of gamma-aminobutyric acid secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014053" ; a owl:Class ; rdfs:label "negative regulation of gamma-aminobutyric acid secretion" ; rdfs:subClassOf obo:GO_0014052, obo:GO_0051048, obo:GO_0051956, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014051 ] ) ] . obo:GO_0014054 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." ; oboInOwl:hasExactSynonym "positive regulation of GABA secretion", "up regulation of gamma-aminobutyric acid secretion", "up-regulation of gamma-aminobutyric acid secretion", "upregulation of gamma-aminobutyric acid secretion" ; oboInOwl:hasNarrowSynonym "activation of gamma-aminobutyric acid secretion", "stimulation of gamma-aminobutyric acid secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014054" ; a owl:Class ; rdfs:label "positive regulation of gamma-aminobutyric acid secretion" ; rdfs:subClassOf obo:GO_0014052, obo:GO_0051047, obo:GO_0051957, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014051 ] ) ] . obo:GO_0014055 obo:IAO_0000115 "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014055" ; a owl:Class ; rdfs:label "acetylcholine secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0007269, obo:GO_0061526, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0061526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007271 ] ) ] . obo:GO_0014056 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014056" ; a owl:Class ; rdfs:label "regulation of acetylcholine secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0032222, obo:GO_0046928, obo:GO_0051952, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014055 ] ) ] . obo:GO_0014057 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." ; oboInOwl:hasExactSynonym "up regulation of acetylcholine secretion", "up-regulation of acetylcholine secretion", "upregulation of acetylcholine secretion" ; oboInOwl:hasNarrowSynonym "activation of acetylcholine secretion", "stimulation of acetylcholine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014057" ; a owl:Class ; rdfs:label "positive regulation of acetylcholine secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0001956, obo:GO_0014056, obo:GO_0032224, obo:GO_0051954, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014055 ] ) ] . obo:GO_0014058 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." ; oboInOwl:hasExactSynonym "down regulation of acetylcholine secretion", "down-regulation of acetylcholine secretion", "downregulation of acetylcholine secretion" ; oboInOwl:hasNarrowSynonym "inhibition of acetylcholine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014058" ; a owl:Class ; rdfs:label "negative regulation of acetylcholine secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0014056, obo:GO_0032223, obo:GO_0046929, obo:GO_0051953, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014055 ] ) ] . obo:GO_0014059 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014059" ; a owl:Class ; rdfs:label "regulation of dopamine secretion" ; rdfs:subClassOf obo:GO_0050433, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014046 ] ) ] . obo:GO_0014060 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." ; oboInOwl:hasExactSynonym "regulation of adrenaline secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014060" ; a owl:Class ; rdfs:label "regulation of epinephrine secretion" ; rdfs:subClassOf obo:GO_0050433, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:GO_0014061 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." ; oboInOwl:hasExactSynonym "regulation of noradrenaline secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014061" ; a owl:Class ; rdfs:label "regulation of norepinephrine secretion" ; rdfs:subClassOf obo:GO_0050433, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048243 ] ) ] . obo:GO_0014062 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of serotonin release" ; oboInOwl:id "GO:0014062" ; a owl:Class ; rdfs:label "regulation of serotonin secretion" ; rdfs:subClassOf obo:GO_0043269, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001820 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001820 ] ) ] . obo:GO_0014063 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." ; oboInOwl:hasExactSynonym "down regulation of serotonin secretion", "down-regulation of serotonin secretion", "downregulation of serotonin secretion" ; oboInOwl:hasNarrowSynonym "inhibition of serotonin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of serotonin release" ; oboInOwl:id "GO:0014063" ; a owl:Class ; rdfs:label "negative regulation of serotonin secretion" ; rdfs:subClassOf obo:GO_0014062, obo:GO_0043271, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001820 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001820 ] ) ] . obo:GO_0014064 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." ; oboInOwl:hasExactSynonym "up regulation of serotonin secretion", "up-regulation of serotonin secretion", "upregulation of serotonin secretion" ; oboInOwl:hasNarrowSynonym "activation of serotonin secretion", "stimulation of serotonin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of serotonin release" ; oboInOwl:id "GO:0014064" ; a owl:Class ; rdfs:label "positive regulation of serotonin secretion" ; rdfs:subClassOf obo:GO_0014062, obo:GO_0043270, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001820 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001820 ] ) ] . obo:GO_0014819 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014819" ; a owl:Class ; rdfs:label "regulation of skeletal muscle contraction" ; rdfs:subClassOf obo:GO_0006942, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003009 ] ) ] . obo:GO_0014821 obo:IAO_0000115 "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014821" ; a owl:Class ; rdfs:label "phasic smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006939 . obo:GO_0014827 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014827" ; a owl:Class ; rdfs:label "intestine smooth muscle contraction" ; rdfs:subClassOf obo:GO_0014821, obo:GO_0014831 . obo:GO_0014831 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014831" ; a owl:Class ; rdfs:label "gastro-intestinal system smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006939 . obo:GO_0014832 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014832" ; a owl:Class ; rdfs:label "urinary bladder smooth muscle contraction" ; rdfs:subClassOf obo:GO_0014848 . obo:GO_0014848 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014848" ; a owl:Class ; rdfs:label "urinary tract smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006939 . obo:GO_0014852 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014852" ; a owl:Class ; rdfs:label "regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction" ; rdfs:subClassOf obo:GO_0014819 . obo:GO_0014853 obo:IAO_0000115 "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." ; oboInOwl:hasExactSynonym "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014853" ; a owl:Class ; rdfs:label "regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction" ; rdfs:subClassOf obo:GO_0098815, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003009 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014852 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0098815 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003009 ] ) ] . obo:GO_0014860 obo:IAO_0000115 "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." ; oboInOwl:hasExactSynonym "neurotransmitter secretion involved in control of skeletal muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0014860" ; a owl:Class ; rdfs:label "neurotransmitter secretion involved in regulation of skeletal muscle contraction" ; rdfs:subClassOf obo:GO_0007269, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014852 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007269 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014819 ] ) ] . obo:GO_0014861 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of skeletal muscle contraction via membrane action potential" ; oboInOwl:id "GO:0014861" ; a owl:Class ; rdfs:label "regulation of skeletal muscle contraction via regulation of action potential" ; rdfs:subClassOf obo:GO_0014819, obo:GO_0098900, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0100001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050789 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0100001 ] ) ] . obo:GO_0015031 obo:IAO_0000115 "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasAlternativeId "GO:0015831" ; oboInOwl:hasNarrowSynonym "enzyme transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015031" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "protein transport" ; rdfs:subClassOf obo:GO_0045184, obo:GO_0071702, obo:GO_0071705 . obo:GO_0015106 obo:IAO_0000115 "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." ; oboInOwl:hasDbXref "RHEA:28695", "Reactome:R-HSA-2752067" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0015106" ; a owl:Class ; rdfs:label "bicarbonate transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0008514, obo:GO_0015318, obo:GO_1901702, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0015701 ] . obo:GO_0015318 obo:IAO_0000115 "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14372"^^xsd:anyURI ; oboInOwl:hasExactSynonym "inorganic solute uptake transmembrane transporter activity", "inorganic uptake permease activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0015318" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "inorganic molecular entity transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0022857 . obo:GO_0015629 obo:IAO_0000115 "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0015629" ; a owl:Class ; rdfs:label "actin cytoskeleton" ; rdfs:subClassOf obo:GO_0005856 . obo:GO_0015669 obo:IAO_0000115 "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015669" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "gas transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0015671 obo:IAO_0000115 "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015671" ; a owl:Class ; rdfs:label "oxygen transport" ; rdfs:subClassOf obo:GO_0015669 . obo:GO_0015695 obo:IAO_0000115 "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015695" ; a owl:Class ; rdfs:label "organic cation transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0015697 obo:IAO_0000115 "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." ; oboInOwl:hasAlternativeId "GO:0015845" ; oboInOwl:hasExactSynonym "quaternary amine transport", "quaternary ammonium compound transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015697" ; a owl:Class ; rdfs:label "quaternary ammonium group transport" ; rdfs:subClassOf obo:GO_0071702, obo:GO_0071705 . obo:GO_0015701 obo:IAO_0000115 "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015701" ; a owl:Class ; rdfs:label "bicarbonate transport" ; rdfs:subClassOf obo:GO_0015711, obo:GO_0019755 . obo:GO_0015711 obo:IAO_0000115 "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015711" ; a owl:Class ; rdfs:label "organic anion transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0015718 obo:IAO_0000115 "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015718" ; a owl:Class ; rdfs:label "monocarboxylic acid transport" ; rdfs:subClassOf obo:GO_0046942 . obo:GO_0015721 obo:IAO_0000115 "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasNarrowSynonym "bile acid transport", "bile salt transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015721" ; a owl:Class ; rdfs:label "bile acid and bile salt transport" ; rdfs:subClassOf obo:GO_0006869, obo:GO_0015718, obo:GO_0015850 . obo:GO_0015749 obo:IAO_0000115 "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2017-02-19T10:41:27Z" ; oboInOwl:hasAlternativeId "GO:1905950" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "monosaccharide transport" ; oboInOwl:id "GO:0015749" ; a owl:Class ; rdfs:label "monosaccharide transmembrane transport" ; rdfs:subClassOf obo:GO_0034219 . obo:GO_0015800 obo:IAO_0000115 "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015800" ; a owl:Class ; rdfs:label "acidic amino acid transport" ; rdfs:subClassOf obo:GO_0006865 . obo:GO_0015807 obo:IAO_0000115 "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015807" ; a owl:Class ; rdfs:label "L-amino acid transport" ; rdfs:subClassOf obo:GO_0006865 . obo:GO_0015812 obo:IAO_0000115 "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "4-aminobutanoate transport", "4-aminobutyrate transport", "GABA transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015812" ; a owl:Class ; rdfs:comment "See also the biological process term 'neurotransmitter transport ; GO:0006836'." ; rdfs:label "gamma-aminobutyric acid transport" ; rdfs:subClassOf obo:GO_0006865 . obo:GO_0015833 obo:IAO_0000115 "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015833" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "peptide transport" ; rdfs:subClassOf obo:GO_0042886, obo:GO_0071702 . obo:GO_0015837 obo:IAO_0000115 "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "amine/polyamine transport" ; oboInOwl:id "GO:0015837" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "amine transport" ; rdfs:subClassOf obo:GO_0071702, obo:GO_0071705 . obo:GO_0015844 obo:IAO_0000115 "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasAlternativeId "GO:0015873" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015844" ; a owl:Class ; rdfs:label "monoamine transport" ; rdfs:subClassOf obo:GO_0071702, obo:GO_0071705 . obo:GO_0015849 obo:IAO_0000115 "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015849" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "organic acid transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0015850 obo:IAO_0000115 "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." ; oboInOwl:hasExactSynonym "organic alcohol transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015850" ; a owl:Class ; rdfs:label "organic hydroxy compound transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0015870 obo:IAO_0000115 "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015870" ; a owl:Class ; rdfs:label "acetylcholine transport" ; rdfs:subClassOf obo:GO_0015695, obo:GO_0015697, obo:GO_1901374 . obo:GO_0015872 obo:IAO_0000115 "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015872" ; a owl:Class ; rdfs:label "dopamine transport" ; rdfs:subClassOf obo:GO_0051937 . obo:GO_0015874 obo:IAO_0000115 "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." ; oboInOwl:hasExactSynonym "levarterenol transport", "noradrenaline transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015874" ; a owl:Class ; rdfs:label "norepinephrine transport" ; rdfs:subClassOf obo:GO_0015695, obo:GO_0051937 . obo:GO_0015925 obo:IAO_0000115 "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0015925" ; a owl:Class ; rdfs:label "galactosidase activity" ; rdfs:subClassOf obo:GO_0004553 . obo:GO_0015980 obo:IAO_0000115 "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." ; oboInOwl:hasExactSynonym "chemoorganotrophy" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0015980" ; a owl:Class ; rdfs:label "energy derivation by oxidation of organic compounds" ; rdfs:subClassOf obo:GO_0006091 . obo:GO_0016020 obo:IAO_0000115 "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." ; oboInOwl:creation_date "2014-03-06T11:37:54Z" ; oboInOwl:hasAlternativeId "GO:0016021", "GO:0098589", "GO:0098805" ; oboInOwl:hasDbXref "Wikipedia:Biological_membrane", "Wikipedia:Transmembrane_protein" ; oboInOwl:hasNarrowSynonym "integral component of membrane", "integral to membrane", "membrane region", "region of membrane", "whole membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "transmembrane" ; oboInOwl:id "GO:0016020" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_metagenomics, go:goslim_pir, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:label "membrane" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0016043 obo:IAO_0000115 "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." ; oboInOwl:hasAlternativeId "GO:0044235", "GO:0071842" ; oboInOwl:hasExactSynonym "cell organisation", "cellular component organisation at cellular level", "cellular component organisation in other organism", "cellular component organization at cellular level", "cellular component organization in other organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell organization and biogenesis" ; oboInOwl:id "GO:0016043" ; oboInOwl:inSubset go:goslim_agr, go:goslim_mouse, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "cellular component organization" ; rdfs:subClassOf obo:GO_0071840 . obo:GO_0016049 obo:IAO_0000115 "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." ; oboInOwl:hasAlternativeId "GO:0048591" ; oboInOwl:hasExactSynonym "cellular growth", "growth of cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell expansion", "metabolic process resulting in cell growth", "metabolism resulting in cell growth", "non-developmental cell growth", "non-developmental growth of a unicellular organism" ; oboInOwl:id "GO:0016049" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_drosophila, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "cell growth" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0040007 . obo:GO_0016050 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." ; oboInOwl:hasExactSynonym "vesicle organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "vesicle organization and biogenesis" ; oboInOwl:id "GO:0016050" ; oboInOwl:inSubset go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "vesicle organization" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0016051 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." ; oboInOwl:hasAlternativeId "GO:0006093" ; oboInOwl:hasExactSynonym "anabolic carbohydrate metabolic process", "anabolic carbohydrate metabolism", "carbohydrate anabolism", "carbohydrate biosynthesis", "carbohydrate formation", "carbohydrate synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016051" ; a owl:Class ; rdfs:label "carbohydrate biosynthetic process" ; rdfs:subClassOf obo:GO_0005975, obo:GO_1901576 . obo:GO_0016052 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-10-23T16:34:39Z" ; oboInOwl:hasAlternativeId "GO:0006095", "GO:0044276", "GO:0044724" ; oboInOwl:hasExactSynonym "carbohydrate breakdown", "carbohydrate catabolism", "carbohydrate degradation", "catabolic carbohydrate metabolic process", "catabolic carbohydrate metabolism" ; oboInOwl:hasNarrowSynonym "multicellular organismal carbohydrate catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism carbohydrate catabolic process" ; oboInOwl:id "GO:0016052" ; a owl:Class ; rdfs:label "carbohydrate catabolic process" ; rdfs:subClassOf obo:GO_0005975, obo:GO_1901575 . obo:GO_0016053 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." ; oboInOwl:hasExactSynonym "organic acid anabolism", "organic acid biosynthesis", "organic acid formation", "organic acid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016053" ; a owl:Class ; rdfs:label "organic acid biosynthetic process" ; rdfs:subClassOf obo:GO_0006082, obo:GO_0044249, obo:GO_0044283, obo:GO_1901576 . obo:GO_0016064 obo:IAO_0000115 "An immune response mediated by immunoglobulins, whether cell-bound or in solution." ; oboInOwl:hasExactSynonym "antibody-mediated immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016064" ; a owl:Class ; rdfs:label "immunoglobulin mediated immune response" ; rdfs:subClassOf obo:GO_0019724 . obo:GO_0016101 obo:IAO_0000115 "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." ; oboInOwl:hasExactSynonym "diterpenoid metabolism" ; oboInOwl:hasNarrowSynonym "diterpene metabolic process", "diterpene metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016101" ; a owl:Class ; rdfs:label "diterpenoid metabolic process" ; rdfs:subClassOf obo:GO_0006721 . obo:GO_0016125 obo:IAO_0000115 "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." ; oboInOwl:hasExactSynonym "sterol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016125" ; a owl:Class ; rdfs:label "sterol metabolic process" ; rdfs:subClassOf obo:GO_0008202, obo:GO_1901615 . obo:GO_0016137 obo:IAO_0000115 "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." ; oboInOwl:hasAlternativeId "GO:0016140" ; oboInOwl:hasExactSynonym "O-glycoside metabolic process", "O-glycoside metabolism", "glycoside metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016137" ; a owl:Class ; rdfs:label "glycoside metabolic process" ; rdfs:subClassOf obo:GO_1901657 . obo:GO_0016160 obo:IAO_0000115 "Catalysis of the hydrolysis of amylose or an amylose derivative." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016160" ; a owl:Class ; rdfs:label "amylase activity" ; rdfs:subClassOf obo:GO_0004553 . obo:GO_0016192 obo:IAO_0000115 "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/25421"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0006899" ; oboInOwl:hasExactSynonym "vesicle transport", "vesicular transport" ; oboInOwl:hasNarrowSynonym "nonselective vesicle transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "protein sorting along secretory pathway", "vesicle trafficking" ; oboInOwl:id "GO:0016192" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe ; a owl:Class ; rdfs:label "vesicle-mediated transport" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0009987 . obo:GO_0016234 obo:IAO_0000115 "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." ; oboInOwl:hasDbXref "NIF_Subcellular:sao120573470", "Wikipedia:Inclusion_bodies" ; oboInOwl:hasNarrowSynonym "neuronal cytoplasmic inclusion" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "cellular inclusion" ; oboInOwl:id "GO:0016234" ; a owl:Class ; rdfs:label "inclusion body" ; rdfs:subClassOf obo:GO_0005622 . obo:GO_0016301 obo:IAO_0000115 "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ; oboInOwl:hasDbXref "Reactome:R-HSA-6788855", "Reactome:R-HSA-6788867" ; oboInOwl:hasExactSynonym "phosphokinase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016301" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_metagenomics, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term." ; rdfs:label "kinase activity" ; rdfs:subClassOf obo:GO_0016772, [ a owl:Restriction ; owl:hasSelf true ; owl:onProperty obo:RO_0002481 ] . obo:GO_0016310 obo:IAO_0000115 "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." ; oboInOwl:hasDbXref "Wikipedia:Phosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016310" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_metagenomics ; a owl:Class ; rdfs:label "phosphorylation" ; rdfs:subClassOf obo:GO_0006796 . obo:GO_0016311 obo:IAO_0000115 "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." ; oboInOwl:hasDbXref "Wikipedia:Dephosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016311" ; a owl:Class ; rdfs:label "dephosphorylation" ; rdfs:subClassOf obo:GO_0006796 . obo:GO_0016321 obo:IAO_0000115 "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016321" ; a owl:Class ; rdfs:label "female meiosis chromosome segregation" ; rdfs:subClassOf obo:GO_0022412, obo:GO_0045132, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007143 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0098813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007143 ] ) ] . obo:GO_0016331 obo:IAO_0000115 "The process in which the anatomical structures of embryonic epithelia are generated and organized." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016331" ; a owl:Class ; rdfs:label "morphogenesis of embryonic epithelium" ; rdfs:subClassOf obo:GO_0002009, obo:GO_0048598 . obo:GO_0016406 obo:IAO_0000115 "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016406" ; a owl:Class ; rdfs:label "carnitine O-acyltransferase activity" ; rdfs:subClassOf obo:GO_0008374 . obo:GO_0016409 obo:IAO_0000115 "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." ; oboInOwl:hasDbXref "Reactome:R-HSA-203567", "Reactome:R-HSA-5686304" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016409" ; a owl:Class ; rdfs:label "palmitoyltransferase activity" ; rdfs:subClassOf obo:GO_0016747 . obo:GO_0016416 obo:IAO_0000115 "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." ; oboInOwl:hasDbXref "Reactome:R-HSA-2404137", "Reactome:R-HSA-2453855", "Reactome:R-HSA-2466710" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016416" ; a owl:Class ; rdfs:label "O-palmitoyltransferase activity" ; rdfs:subClassOf obo:GO_0008374, obo:GO_0016409 . obo:GO_0016421 obo:IAO_0000115 "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016421" ; a owl:Class ; rdfs:label "CoA carboxylase activity" ; rdfs:subClassOf obo:GO_0016885 . obo:GO_0016444 obo:IAO_0000115 "Recombination occurring within or between DNA molecules in somatic cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016444" ; a owl:Class ; rdfs:label "somatic cell DNA recombination" ; rdfs:subClassOf obo:GO_0006310 . obo:GO_0016445 obo:IAO_0000115 "The somatic process that results in the generation of sequence diversity of immunoglobulins." ; oboInOwl:hasExactSynonym "somatic diversification of antibodies" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016445" ; a owl:Class ; rdfs:label "somatic diversification of immunoglobulins" ; rdfs:subClassOf obo:GO_0002200, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0002377 ] . obo:GO_0016446 obo:IAO_0000115 "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." ; oboInOwl:hasExactSynonym "somatic hypermutation of antibody genes" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016446" ; a owl:Class ; rdfs:label "somatic hypermutation of immunoglobulin genes" ; rdfs:subClassOf obo:GO_0002566, obo:GO_0016445 . obo:GO_0016447 obo:IAO_0000115 "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." ; oboInOwl:hasExactSynonym "somatic recombination of antibody gene segments" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016447" ; a owl:Class ; rdfs:label "somatic recombination of immunoglobulin gene segments" ; rdfs:subClassOf obo:GO_0002562, obo:GO_0016445 . obo:GO_0016469 obo:IAO_0000115 "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/15936"^^xsd:anyURI ; oboInOwl:hasExactSynonym "hydrogen-transporting two-sector ATPase complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "vacuolar hydrogen-transporting ATPase" ; oboInOwl:id "GO:0016469" ; oboInOwl:inSubset go:goslim_metagenomics, go:goslim_pir ; a owl:Class ; rdfs:label "proton-transporting two-sector ATPase complex" ; rdfs:subClassOf obo:GO_0098796, obo:GO_1904949 . obo:GO_0016477 obo:IAO_0000115 "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24787"^^xsd:anyURI ; obo:RO_0002161 obo:NCBITaxon_4890 ; oboInOwl:hasDbXref "Wikipedia:Cell_migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016477" ; a owl:Class ; rdfs:label "cell migration" ; rdfs:subClassOf obo:GO_0048870 . obo:GO_0016485 obo:IAO_0000115 "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." ; oboInOwl:hasAlternativeId "GO:0051605" ; oboInOwl:hasExactSynonym "protein maturation by peptide bond cleavage", "protein maturation by peptide bond hydrolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "peptidolysis during protein maturation", "protein maturation by proteolysis" ; oboInOwl:id "GO:0016485" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "protein processing" ; rdfs:subClassOf obo:GO_0006508, obo:GO_0051604 . obo:GO_0016491 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." ; oboInOwl:hasDbXref "EC:1.-.-.-", "Reactome:R-HSA-1614362", "Reactome:R-HSA-209921", "Reactome:R-HSA-209960", "Reactome:R-HSA-3095889", "Reactome:R-HSA-390425", "Reactome:R-HSA-390438", "Reactome:R-HSA-5662660", "Reactome:R-HSA-8878581", "Reactome:R-HSA-8936442", "Reactome:R-HSA-9020249", "Reactome:R-HSA-9020260", "Reactome:R-HSA-9024624", "Reactome:R-HSA-9024630", "Reactome:R-HSA-9025007", "Reactome:R-HSA-9026001", "Reactome:R-HSA-9026917", "Reactome:R-HSA-9027033", "Reactome:R-HSA-9693722" ; oboInOwl:hasExactSynonym "redox activity" ; oboInOwl:hasNarrowSynonym "oxidoreductase activity, acting on other substrates" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016491" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "oxidoreductase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016525 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." ; oboInOwl:hasExactSynonym "down regulation of angiogenesis", "down-regulation of angiogenesis", "downregulation of angiogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of angiogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0016525" ; a owl:Class ; rdfs:label "negative regulation of angiogenesis" ; rdfs:subClassOf obo:GO_0045765, obo:GO_2000181, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001525 ] ) ] . obo:GO_0016614 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." ; oboInOwl:hasDbXref "EC:1.1.-.-", "Reactome:R-HSA-1500781" ; oboInOwl:hasNarrowSynonym "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016614" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on CH-OH group of donors" ; rdfs:subClassOf obo:GO_0016491 . obo:GO_0016616 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." ; oboInOwl:hasDbXref "EC:1.1.1.-", "Reactome:R-HSA-975629" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "NADH-dependent glyoxylate reductase", "glycolate reductase", "glyoxylic acid reductase" ; oboInOwl:id "GO:0016616" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" ; rdfs:subClassOf obo:GO_0016614 . obo:GO_0016620 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." ; oboInOwl:hasDbXref "EC:1.2.1.-", "Reactome:R-HSA-1222583" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016620" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" ; rdfs:subClassOf obo:GO_0016903 . obo:GO_0016667 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." ; oboInOwl:hasDbXref "EC:1.8.-.-", "Reactome:R-HSA-2213240" ; oboInOwl:hasExactSynonym "oxidoreductase activity, acting on sulphur group of donors" ; oboInOwl:hasNarrowSynonym "oxidoreductase activity, acting on sulfur group of donors, other acceptors" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016667" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on a sulfur group of donors" ; rdfs:subClassOf obo:GO_0016491 . obo:GO_0016670 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." ; oboInOwl:hasDbXref "EC:1.8.3.-" ; oboInOwl:hasExactSynonym "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016670" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor" ; rdfs:subClassOf obo:GO_0016667 . obo:GO_0016740 obo:IAO_0000115 "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." ; oboInOwl:hasDbXref "EC:2.-.-.-", "Reactome:R-HSA-1483089", "Reactome:R-HSA-1483186", "Reactome:R-HSA-5668414", "Reactome:R-HSA-8868783" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016740" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "transferase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016746 obo:IAO_0000115 "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20486"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0008415" ; oboInOwl:hasDbXref "EC:2.3.-.-", "Reactome:R-HSA-159431", "Reactome:R-HSA-192312", "Reactome:R-HSA-193491", "Reactome:R-HSA-6792572", "Reactome:R-HSA-8858298" ; oboInOwl:hasExactSynonym "transferase activity, transferring acyl groups" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016746" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila ; a owl:Class ; rdfs:label "acyltransferase activity" ; rdfs:subClassOf obo:GO_0016740 . obo:GO_0016747 obo:IAO_0000115 "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20486"^^xsd:anyURI ; oboInOwl:hasDbXref "EC:2.3.1.-" ; oboInOwl:hasExactSynonym "transferase activity, transferring acyl groups other than amino-acyl groups" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "transferase activity, transferring groups other than amino-acyl groups" ; oboInOwl:id "GO:0016747" ; a owl:Class ; rdfs:label "acyltransferase activity, transferring groups other than amino-acyl groups" ; rdfs:subClassOf obo:GO_0016746 . obo:GO_0016769 obo:IAO_0000115 "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." ; oboInOwl:hasDbXref "EC:2.6.-.-" ; oboInOwl:hasNarrowSynonym "transferase activity, transferring other nitrogenous groups" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016769" ; a owl:Class ; rdfs:label "transferase activity, transferring nitrogenous groups" ; rdfs:subClassOf obo:GO_0016740 . obo:GO_0016772 obo:IAO_0000115 "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." ; oboInOwl:hasDbXref "EC:2.7.-.-" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016772" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:comment "Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides." ; rdfs:label "transferase activity, transferring phosphorus-containing groups" ; rdfs:subClassOf obo:GO_0016740 . obo:GO_0016774 obo:IAO_0000115 "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." ; oboInOwl:hasDbXref "EC:2.7.2.-" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016774" ; a owl:Class ; rdfs:label "phosphotransferase activity, carboxyl group as acceptor" ; rdfs:subClassOf obo:GO_0016772 . obo:GO_0016787 obo:IAO_0000115 "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." ; oboInOwl:hasDbXref "EC:3.-.-.-", "Reactome:R-HSA-1236938", "Reactome:R-HSA-2029475", "Reactome:R-HSA-5694583", "Reactome:R-HSA-5695964", "Reactome:R-HSA-6786190", "Reactome:R-HSA-6788295", "Reactome:R-HSA-8938314", "Reactome:R-HSA-8952137" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016787" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "hydrolase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016788 obo:IAO_0000115 "Catalysis of the hydrolysis of any ester bond." ; oboInOwl:hasDbXref "EC:3.1.-.-", "Reactome:R-HSA-162729", "Reactome:R-HSA-9023617", "Reactome:R-HSA-9023619", "Reactome:R-HSA-9749609" ; oboInOwl:hasExactSynonym "esterase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016788" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "hydrolase activity, acting on ester bonds" ; rdfs:subClassOf obo:GO_0016787 . obo:GO_0016791 obo:IAO_0000115 "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." ; oboInOwl:hasAlternativeId "GO:0003869", "GO:0016302" ; oboInOwl:hasDbXref "EC:3.1.3.-", "MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN", "Reactome:R-HSA-4419986", "Reactome:R-HSA-9636457" ; oboInOwl:hasExactSynonym "phosphoric monoester hydrolase activity" ; oboInOwl:hasNarrowSynonym "4-nitrophenylphosphatase activity", "4-nitrophenylphosphate phosphohydrolase activity", "K-pNPPase activity", "NPPase activity", "PNPPase activity", "ecto-p-nitrophenyl phosphatase activity", "nitrophenyl phosphatase activity", "p-nitrophenylphosphatase activity", "p-nitrophenylphosphate phosphohydrolase activity", "para-nitrophenyl phosphatase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "phosphatase" ; oboInOwl:id "GO:0016791" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_metagenomics, go:goslim_yeast ; a owl:Class ; rdfs:label "phosphatase activity" ; rdfs:subClassOf obo:GO_0042578 . obo:GO_0016798 obo:IAO_0000115 "Catalysis of the hydrolysis of any glycosyl bond." ; oboInOwl:hasDbXref "EC:3.2.-.-", "Reactome:R-HSA-1793176", "Reactome:R-HSA-2065233" ; oboInOwl:hasExactSynonym "glycosidase activity" ; oboInOwl:hasNarrowSynonym "N-glycosylase", "glycosylase" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016798" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_yeast ; a owl:Class ; rdfs:label "hydrolase activity, acting on glycosyl bonds" ; rdfs:subClassOf obo:GO_0016787 . obo:GO_0016829 obo:IAO_0000115 "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." ; oboInOwl:hasDbXref "EC:4.-.-.-", "Reactome:R-HSA-5696408", "Reactome:R-HSA-6782895" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016829" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "lyase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016835 obo:IAO_0000115 "Catalysis of the breakage of a carbon-oxygen bond." ; oboInOwl:hasDbXref "EC:4.2.-.-" ; oboInOwl:hasNarrowSynonym "other carbon-oxygen lyase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016835" ; a owl:Class ; rdfs:label "carbon-oxygen lyase activity" ; rdfs:subClassOf obo:GO_0016829 . obo:GO_0016836 obo:IAO_0000115 "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." ; oboInOwl:hasDbXref "EC:4.2.1.-", "Reactome:R-HSA-9014627" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016836" ; a owl:Class ; rdfs:label "hydro-lyase activity" ; rdfs:subClassOf obo:GO_0016835 . obo:GO_0016853 obo:IAO_0000115 "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." ; oboInOwl:hasDbXref "EC:5.-.-.-", "Reactome:R-HSA-6787623" ; oboInOwl:hasNarrowSynonym "other isomerase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016853" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "isomerase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016866 obo:IAO_0000115 "Catalysis of the transfer of a functional group from one position to another within a single molecule." ; oboInOwl:hasDbXref "EC:5.4.-.-" ; oboInOwl:hasExactSynonym "mutase activity" ; oboInOwl:hasNarrowSynonym "intramolecular transferase activity, transferring other groups" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016866" ; a owl:Class ; rdfs:label "intramolecular transferase activity" ; rdfs:subClassOf obo:GO_0016853 . obo:GO_0016868 obo:IAO_0000115 "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." ; oboInOwl:hasAlternativeId "GO:0016777" ; oboInOwl:hasDbXref "EC:5.4.2.-" ; oboInOwl:hasExactSynonym "phosphomutase activity", "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016868" ; a owl:Class ; rdfs:label "intramolecular transferase activity, phosphotransferases" ; rdfs:subClassOf obo:GO_0016866 . obo:GO_0016874 obo:IAO_0000115 "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19380"^^xsd:anyURI ; oboInOwl:hasDbXref "EC:6.-.-.-" ; oboInOwl:hasExactSynonym "synthetase activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016874" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "ligase activity" ; rdfs:subClassOf obo:GO_0003824 . obo:GO_0016885 obo:IAO_0000115 "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." ; oboInOwl:hasDbXref "EC:6.4.-.-" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016885" ; a owl:Class ; rdfs:label "ligase activity, forming carbon-carbon bonds" ; rdfs:subClassOf obo:GO_0016874 . obo:GO_0016903 obo:IAO_0000115 "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." ; oboInOwl:hasDbXref "EC:1.2.-.-" ; oboInOwl:hasNarrowSynonym "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0016903" ; a owl:Class ; rdfs:label "oxidoreductase activity, acting on the aldehyde or oxo group of donors" ; rdfs:subClassOf obo:GO_0016491 . obo:GO_0017145 obo:IAO_0000115 "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." ; obo:RO_0002161 obo:NCBITaxon_Union_0000023 ; oboInOwl:hasExactSynonym "stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0017145" ; a owl:Class ; rdfs:label "stem cell division" ; rdfs:subClassOf obo:GO_0051301 . obo:GO_0017148 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." ; oboInOwl:hasAlternativeId "GO:0016478" ; oboInOwl:hasExactSynonym "down regulation of protein biosynthetic process", "down-regulation of protein biosynthetic process", "downregulation of protein biosynthetic process", "negative regulation of protein anabolism", "negative regulation of protein biosynthesis", "negative regulation of protein biosynthetic process", "negative regulation of protein formation", "negative regulation of protein synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of protein biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "protein biosynthesis inhibitor activity", "protein biosynthetic process inhibitor activity" ; oboInOwl:id "GO:0017148" ; a owl:Class ; rdfs:label "negative regulation of translation" ; rdfs:subClassOf obo:GO_0006417, obo:GO_0010558, obo:GO_0010629, obo:GO_0031327, obo:GO_0034249, obo:GO_0051248, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0017157 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of exocytosis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0017157" ; a owl:Class ; rdfs:label "regulation of exocytosis" ; rdfs:subClassOf obo:GO_0060627, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006887 ] ) ] . obo:GO_0018130 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." ; oboInOwl:hasExactSynonym "heterocycle anabolism", "heterocycle biosynthesis", "heterocycle formation", "heterocycle synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0018130" ; a owl:Class ; rdfs:label "heterocycle biosynthetic process" ; rdfs:subClassOf obo:GO_0044249, obo:GO_0046483 . obo:GO_0018958 obo:IAO_0000115 "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." ; oboInOwl:hasDbXref "UM-BBD_pathwayID:phe" ; oboInOwl:hasExactSynonym "carbolic acid metabolic process", "carbolic acid metabolism", "hydroxybenzene metabolic process", "hydroxybenzene metabolism", "phenol-containing compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0018958" ; a owl:Class ; rdfs:comment "Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds." ; rdfs:label "phenol-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_1901360, obo:GO_1901615 . obo:GO_0019098 obo:IAO_0000115 "The specific behavior of an organism that is associated with reproduction." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23491"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T16:01:37Z" ; oboInOwl:hasAlternativeId "GO:0033057", "GO:0044704", "GO:0044705" ; oboInOwl:hasExactSynonym "reproductive behavior in a multicellular organism", "reproductive behaviour" ; oboInOwl:hasNarrowSynonym "multi-organism reproductive behavior", "multicellular organism reproductive behavior" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism reproductive behavior" ; oboInOwl:id "GO:0019098" ; a owl:Class ; rdfs:label "reproductive behavior" ; rdfs:subClassOf obo:GO_0007610, obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007610 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032504 ] ) ] . obo:GO_0019172 obo:IAO_0000115 "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." ; oboInOwl:hasDbXref "EC:4.2.1.130", "MetaCyc:GLYOXIII-RXN", "RHEA:27754" ; oboInOwl:hasExactSynonym "(R)-lactate hydro-lyase", "D-lactate dehydratase" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "glutathione-independent glyoxalase activity" ; oboInOwl:id "GO:0019172" ; a owl:Class ; rdfs:comment "Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase)." ; rdfs:label "glyoxalase III activity" ; rdfs:subClassOf obo:GO_0016836, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019249 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0061727 ] . obo:GO_0019216 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." ; oboInOwl:hasExactSynonym "regulation of lipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019216" ; a owl:Class ; rdfs:label "regulation of lipid metabolic process" ; rdfs:subClassOf obo:GO_0080090, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006629 ] ) ] . obo:GO_0019217 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." ; oboInOwl:hasAlternativeId "GO:0006632" ; oboInOwl:hasExactSynonym "regulation of fatty acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019217" ; a owl:Class ; rdfs:label "regulation of fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0010565, obo:GO_0019216, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006631 ] ) ] . obo:GO_0019218 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." ; oboInOwl:hasExactSynonym "regulation of steroid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019218" ; a owl:Class ; rdfs:label "regulation of steroid metabolic process" ; rdfs:subClassOf obo:GO_0019216, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008202 ] ) ] . obo:GO_0019219 obo:IAO_0000115 "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." ; oboInOwl:hasExactSynonym "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:id "GO:0019219" ; a owl:Class ; rdfs:label "regulation of nucleobase-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0031323, obo:GO_0051171, obo:GO_0080090, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006139 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006139 ] ) ] . obo:GO_0019220 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." ; oboInOwl:hasExactSynonym "regulation of phosphate metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019220" ; a owl:Class ; rdfs:label "regulation of phosphate metabolic process" ; rdfs:subClassOf obo:GO_0051174, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006796 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006796 ] ) ] . obo:GO_0019221 obo:IAO_0000115 "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." ; oboInOwl:hasExactSynonym "cytokine and chemokine mediated signaling pathway", "cytokine mediated signalling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019221" ; a owl:Class ; rdfs:label "cytokine-mediated signaling pathway" ; rdfs:subClassOf obo:GO_0007166, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0071345 ] . obo:GO_0019222 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." ; oboInOwl:hasAlternativeId "GO:0044246" ; oboInOwl:hasExactSynonym "regulation of metabolism" ; oboInOwl:hasNarrowSynonym "regulation of multicellular organismal metabolic process", "regulation of organismal metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019222" ; oboInOwl:inSubset go:goslim_metagenomics ; a owl:Class ; rdfs:label "regulation of metabolic process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008152 ] ) ] . obo:GO_0019226 obo:IAO_0000115 "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." ; oboInOwl:hasExactSynonym "conduction of nerve impulse", "signal transmission along a neuron" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019226" ; a owl:Class ; rdfs:label "transmission of nerve impulse" ; rdfs:subClassOf obo:GO_0050877, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007154 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0001508 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0007268 ] . obo:GO_0019230 obo:IAO_0000115 "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." ; oboInOwl:hasDbXref "Wikipedia:Proprioception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019230" ; a owl:Class ; rdfs:label "proprioception" ; rdfs:subClassOf obo:GO_0007600, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050884 ] . obo:GO_0019233 obo:IAO_0000115 "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." ; oboInOwl:hasDbXref "Wikipedia:Nociception" ; oboInOwl:hasNarrowSynonym "perception of physiological pain" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nociception" ; oboInOwl:id "GO:0019233" ; a owl:Class ; rdfs:label "sensory perception of pain" ; rdfs:subClassOf obo:GO_0007600 . obo:GO_0019249 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." ; oboInOwl:hasExactSynonym "lactate anabolism", "lactate biosynthesis", "lactate formation", "lactate synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019249" ; a owl:Class ; rdfs:label "lactate biosynthetic process" ; rdfs:subClassOf obo:GO_0006089, obo:GO_0072330, obo:GO_1901617 . obo:GO_0019318 obo:IAO_0000115 "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." ; oboInOwl:hasExactSynonym "hexose metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019318" ; a owl:Class ; rdfs:label "hexose metabolic process" ; rdfs:subClassOf obo:GO_0005996 . obo:GO_0019319 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." ; oboInOwl:hasExactSynonym "hexose anabolism", "hexose biosynthesis", "hexose formation", "hexose synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019319" ; a owl:Class ; rdfs:label "hexose biosynthetic process" ; rdfs:subClassOf obo:GO_0019318, obo:GO_0046364 . obo:GO_0019438 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." ; oboInOwl:hasExactSynonym "aromatic compound anabolism", "aromatic compound biosynthesis", "aromatic compound formation", "aromatic compound synthesis" ; oboInOwl:hasNarrowSynonym "aromatic hydrocarbon biosynthesis", "aromatic hydrocarbon biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019438" ; a owl:Class ; rdfs:label "aromatic compound biosynthetic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_0044249 . obo:GO_0019538 obo:IAO_0000115 "The chemical reactions and pathways involving a protein. Includes protein modification." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0006411", "GO:0044267", "GO:0044268" ; oboInOwl:hasDbXref "Wikipedia:Protein_metabolism" ; oboInOwl:hasExactSynonym "cellular protein metabolic process", "cellular protein metabolism", "protein metabolic process and modification", "protein metabolism", "protein metabolism and modification" ; oboInOwl:hasNarrowSynonym "multicellular organismal protein metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019538" ; oboInOwl:inSubset go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "protein metabolic process" ; rdfs:subClassOf obo:GO_0043170, obo:GO_0044238, obo:GO_1901564 . obo:GO_0019724 obo:IAO_0000115 "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." ; oboInOwl:hasExactSynonym "B lymphocyte mediated immune effector process", "B lymphocyte mediated immunity", "B-cell mediated immune effector process", "B-cell mediated immunity", "B-lymphocyte mediated immune effector process", "B-lymphocyte mediated immunity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019724" ; a owl:Class ; rdfs:label "B cell mediated immunity" ; rdfs:subClassOf obo:GO_0002449, obo:GO_0002460 . obo:GO_0019725 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state at the level of the cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019725" ; oboInOwl:inSubset go:goslim_candida, go:goslim_plant ; a owl:Class ; rdfs:label "cellular homeostasis" ; rdfs:subClassOf obo:GO_0042592 . obo:GO_0019730 obo:IAO_0000115 "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." ; oboInOwl:hasAlternativeId "GO:0006960", "GO:0019735" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019730" ; a owl:Class ; rdfs:label "antimicrobial humoral response" ; rdfs:subClassOf obo:GO_0006959, obo:GO_0098542 . obo:GO_0019747 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." ; oboInOwl:hasExactSynonym "regulation of isoprenoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019747" ; a owl:Class ; rdfs:label "regulation of isoprenoid metabolic process" ; rdfs:subClassOf obo:GO_0019216, obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006720 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006720 ] ) ] . obo:GO_0019748 obo:IAO_0000115 "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." ; oboInOwl:hasDbXref "Wikipedia:Secondary_metabolism" ; oboInOwl:hasExactSynonym "secondary metabolism", "secondary metabolite metabolic process", "secondary metabolite metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019748" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir, go:goslim_plant, go:goslim_pombe ; a owl:Class ; rdfs:label "secondary metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0019752 obo:IAO_0000115 "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." ; oboInOwl:hasExactSynonym "carboxylic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019752" ; a owl:Class ; rdfs:label "carboxylic acid metabolic process" ; rdfs:subClassOf obo:GO_0043436 . obo:GO_0019755 obo:IAO_0000115 "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "one carbon compound transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019755" ; a owl:Class ; rdfs:label "one-carbon compound transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_0019814 obo:IAO_0000115 "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:hasNarrowSynonym "antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0019814" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:comment "Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "immunoglobulin complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0019815 obo:IAO_0000115 "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." ; oboInOwl:hasAlternativeId "GO:0042570" ; oboInOwl:hasExactSynonym "B lymphocyte receptor complex", "B-cell receptor complex", "B-lymphocyte receptor complex", "BCR complex", "immunoglobulin complex, membrane bound" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "B cell receptor accessory molecule complex", "antibody" ; oboInOwl:id "GO:0019815" ; a owl:Class ; rdfs:comment "Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "B cell receptor complex" ; rdfs:subClassOf obo:GO_0019814, obo:GO_0098802 . obo:GO_0019852 obo:IAO_0000115 "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." ; oboInOwl:hasExactSynonym "L-ascorbic acid metabolism", "ascorbate metabolic process", "ascorbate metabolism", "vitamin C metabolic process", "vitamin C metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019852" ; a owl:Class ; rdfs:label "L-ascorbic acid metabolic process" ; rdfs:subClassOf obo:GO_0005996, obo:GO_0006767, obo:GO_0019752, obo:GO_1901334 . obo:GO_0019866 obo:IAO_0000115 "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0019866" ; a owl:Class ; rdfs:comment "See also the cellular component term 'outer membrane ; GO:0019867'." ; rdfs:label "organelle inner membrane" ; rdfs:subClassOf obo:GO_0031090, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031967 ] . obo:GO_0019882 obo:IAO_0000115 "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." ; oboInOwl:hasAlternativeId "GO:0030333" ; oboInOwl:hasDbXref "Wikipedia:Antigen_presentation" ; oboInOwl:hasExactSynonym "antigen presentation", "antigen processing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019882" ; a owl:Class ; rdfs:label "antigen processing and presentation" ; rdfs:subClassOf obo:GO_0002376 . obo:GO_0019953 obo:IAO_0000115 "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22929"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Sexual_reproduction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0019953" ; a owl:Class ; rdfs:comment "Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." ; rdfs:label "sexual reproduction" ; rdfs:subClassOf obo:GO_0000003 . obo:GO_0021700 obo:IAO_0000115 "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0021700" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "developmental maturation" ; rdfs:subClassOf obo:GO_0032502 . obo:GO_0021782 obo:IAO_0000115 "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0021782" ; a owl:Class ; rdfs:label "glial cell development" ; rdfs:subClassOf obo:GO_0048468, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010001 ] . obo:GO_0021915 obo:IAO_0000115 "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0021915" ; a owl:Class ; rdfs:label "neural tube development" ; rdfs:subClassOf obo:GO_0035295, obo:GO_0060429, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007399 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043009 ] . obo:GO_0022008 obo:IAO_0000115 "Generation of cells within the nervous system." ; oboInOwl:hasDbXref "Wikipedia:Neurogenesis" ; oboInOwl:hasExactSynonym "nervous system cell generation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "neural cell differentiation" ; oboInOwl:id "GO:0022008" ; a owl:Class ; rdfs:label "neurogenesis" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007399 ] . obo:GO_0022010 obo:IAO_0000115 "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." ; oboInOwl:hasExactSynonym "myelination in central nervous system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022010" ; a owl:Class ; rdfs:label "central nervous system myelination" ; rdfs:subClassOf obo:GO_0032291, obo:GO_0042552, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014003 ] . obo:GO_0022011 obo:IAO_0000115 "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." ; oboInOwl:hasExactSynonym "peripheral nervous system myelination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022011" ; a owl:Class ; rdfs:label "myelination in peripheral nervous system" ; rdfs:subClassOf obo:GO_0032292, obo:GO_0042552, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014044 ] . obo:GO_0022402 obo:IAO_0000115 "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022402" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "cell cycle process" ; rdfs:subClassOf obo:GO_0009987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007049 ] ) ] . obo:GO_0022403 obo:IAO_0000115 "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022403" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "cell cycle phase" ; rdfs:subClassOf obo:GO_0044848 . obo:GO_0022407 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022407" ; a owl:Class ; rdfs:label "regulation of cell-cell adhesion" ; rdfs:subClassOf obo:GO_0030155, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0098609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0098609 ] ) ] . obo:GO_0022408 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." ; oboInOwl:hasExactSynonym "down regulation of cell-cell adhesion", "down-regulation of cell-cell adhesion", "downregulation of cell-cell adhesion" ; oboInOwl:hasNarrowSynonym "inhibition of cell-cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022408" ; a owl:Class ; rdfs:label "negative regulation of cell-cell adhesion" ; rdfs:subClassOf obo:GO_0007162, obo:GO_0022407, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0098609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0098609 ] ) ] . obo:GO_0022409 obo:IAO_0000115 "Any process that activates or increases the rate or extent of cell adhesion to another cell." ; oboInOwl:hasExactSynonym "up regulation of cell-cell adhesion", "up-regulation of cell-cell adhesion", "upregulation of cell-cell adhesion" ; oboInOwl:hasNarrowSynonym "activation of cell-cell adhesion", "stimulation of cell-cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022409" ; a owl:Class ; rdfs:label "positive regulation of cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022407, obo:GO_0045785, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0098609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0098609 ] ) ] . obo:GO_0022410 obo:IAO_0000115 "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022410" ; a owl:Class ; rdfs:label "circadian sleep/wake cycle process" ; rdfs:subClassOf obo:GO_0048512, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042745 ] . obo:GO_0022411 obo:IAO_0000115 "A cellular process that results in the breakdown of a cellular component." ; oboInOwl:hasAlternativeId "GO:0071845" ; oboInOwl:hasExactSynonym "cell structure disassembly", "cellular component disassembly at cellular level" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022411" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular component disassembly" ; rdfs:subClassOf obo:GO_0016043 ; owl:disjointWith obo:GO_0022607 . obo:GO_0022412 obo:IAO_0000115 "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." ; oboInOwl:hasExactSynonym "reproductive cellular process in multicellular organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022412" ; a owl:Class ; rdfs:label "cellular process involved in reproduction in multicellular organism" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032504 ] ) ] . obo:GO_0022414 obo:IAO_0000115 "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T15:56:06Z" ; oboInOwl:hasAlternativeId "GO:0044702" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single organism reproductive process" ; oboInOwl:id "GO:0022414" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "reproductive process" ; rdfs:subClassOf obo:GO_0008150, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000003 ] ; owl:disjointWith obo:GO_0044848 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0008150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000003 ] ) ] . obo:GO_0022600 obo:IAO_0000115 "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022600" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "digestive system process" ; rdfs:subClassOf obo:GO_0003008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007586 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0003008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007586 ] ) ] . obo:GO_0022601 obo:IAO_0000115 "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022601" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "menstrual cycle phase" ; rdfs:subClassOf obo:GO_0044848 . obo:GO_0022603 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." ; oboInOwl:hasExactSynonym "regulation of morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022603" ; a owl:Class ; rdfs:label "regulation of anatomical structure morphogenesis" ; rdfs:subClassOf obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009653 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009653 ] ) ] . obo:GO_0022607 obo:IAO_0000115 "The aggregation, arrangement and bonding together of a cellular component." ; oboInOwl:hasAlternativeId "GO:0071844" ; oboInOwl:hasExactSynonym "cell structure assembly", "cellular component assembly at cellular level" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022607" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir ; a owl:Class ; rdfs:label "cellular component assembly" ; rdfs:subClassOf obo:GO_0016043, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0044085 ] . obo:GO_0022857 obo:IAO_0000115 "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." ; oboInOwl:hasAlternativeId "GO:0005386", "GO:0015563", "GO:0015646", "GO:0022891", "GO:0022892" ; oboInOwl:hasDbXref "Reactome:R-HSA-1236947", "Reactome:R-HSA-429036", "Reactome:R-HSA-5638209", "Reactome:R-HSA-5671707", "Reactome:R-HSA-6784434", "Reactome:R-HSA-6784436" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "substrate-specific transmembrane transporter activity", "substrate-specific transporter activity", "uptake permease activity", "uptake transmembrane transporter activity" ; oboInOwl:id "GO:0022857" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_yeast ; a owl:Class ; rdfs:label "transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0005215, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0055085 ] . obo:GO_0022898 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0022898" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0032409, obo:GO_0034762, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022857 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022857 ] ) ] . obo:GO_0023019 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of gene expression as a consequence of signal transmission" ; oboInOwl:id "GO:0023019" ; a owl:Class ; rdfs:label "signal transduction involved in regulation of gene expression" ; rdfs:subClassOf obo:GO_0007165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010468 ] ) ] . obo:GO_0023051 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a signaling process." ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of signaling process", "regulation of signalling process" ; oboInOwl:id "GO:0023051" ; a owl:Class ; rdfs:label "regulation of signaling" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0023052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0023052 ] ) ] . obo:GO_0023052 obo:IAO_0000115 "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasAlternativeId "GO:0023046", "GO:0044700" ; oboInOwl:hasExactSynonym "biological signaling", "signaling process", "signalling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "signalling process", "single organism signaling" ; oboInOwl:id "GO:0023052" ; oboInOwl:inSubset go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_mouse, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change." ; rdfs:label "signaling" ; rdfs:subClassOf obo:GO_0050789 ; owl:disjointWith obo:GO_0044848 . obo:GO_0023056 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasExactSynonym "positive regulation of signalling process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of signaling process" ; oboInOwl:id "GO:0023056" ; a owl:Class ; rdfs:label "positive regulation of signaling" ; rdfs:subClassOf obo:GO_0023051, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0023052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0023052 ] ) ] . obo:GO_0023057 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of signaling process", "negative regulation of signalling process" ; oboInOwl:id "GO:0023057" ; a owl:Class ; rdfs:label "negative regulation of signaling" ; rdfs:subClassOf obo:GO_0023051, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0023052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0023052 ] ) ] . obo:GO_0023061 obo:IAO_0000115 "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." ; oboInOwl:creation_date "2010-02-16T09:30:50Z" ; oboInOwl:hasExactSynonym "signal secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0023061" ; a owl:Class ; rdfs:label "signal release" ; rdfs:subClassOf obo:GO_0032940, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007267 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032940 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007267 ] ) ] . obo:GO_0030003 obo:IAO_0000115 "A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "cellular cation homeostasis" ; oboInOwl:hasExactSynonym "cellular monoatomic cation homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030003" ; a owl:Class ; rdfs:label "intracellular monoatomic cation homeostasis" ; rdfs:subClassOf obo:GO_0006873, obo:GO_0055080 . obo:GO_0030016 obo:IAO_0000115 "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." ; oboInOwl:hasDbXref "Wikipedia:Myofibril" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030016" ; a owl:Class ; rdfs:label "myofibril" ; rdfs:subClassOf obo:GO_0043292 . obo:GO_0030017 obo:IAO_0000115 "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." ; oboInOwl:hasDbXref "Wikipedia:Sarcomere" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030017" ; a owl:Class ; rdfs:label "sarcomere" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030016 ] . obo:GO_0030030 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." ; oboInOwl:hasExactSynonym "cell projection organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell projection organization and biogenesis", "cell surface structure organization and biogenesis" ; oboInOwl:id "GO:0030030" ; oboInOwl:inSubset go:prokaryote_subset ; a owl:Class ; rdfs:label "cell projection organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0030031 obo:IAO_0000115 "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." ; oboInOwl:hasExactSynonym "formation of a cell surface projection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell projection biogenesis" ; oboInOwl:id "GO:0030031" ; a owl:Class ; rdfs:label "cell projection assembly" ; rdfs:subClassOf obo:GO_0022607, obo:GO_0030030 . obo:GO_0030054 obo:IAO_0000115 "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." ; oboInOwl:hasDbXref "Wikipedia:Cell_junction" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030054" ; oboInOwl:inSubset go:goslim_agr, go:goslim_drosophila, go:goslim_flybase_ribbon ; a owl:Class ; rdfs:label "cell junction" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0030072 obo:IAO_0000115 "The regulated release of a peptide hormone from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030072" ; a owl:Class ; rdfs:label "peptide hormone secretion" ; rdfs:subClassOf obo:GO_0002790, obo:GO_0046879 . obo:GO_0030073 obo:IAO_0000115 "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030073" ; a owl:Class ; rdfs:label "insulin secretion" ; rdfs:subClassOf obo:GO_0009306, obo:GO_0030072 . obo:GO_0030097 obo:IAO_0000115 "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22178"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Haematopoiesis" ; oboInOwl:hasExactSynonym "blood cell biosynthesis", "blood cell formation", "haemopoiesis", "hematopoiesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030097" ; a owl:Class ; rdfs:label "hemopoiesis" ; rdfs:subClassOf obo:GO_0048468 . obo:GO_0030098 obo:IAO_0000115 "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ; oboInOwl:hasAlternativeId "GO:0046650" ; oboInOwl:hasExactSynonym "lymphocyte cell differentiation", "lymphocytic blood cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "lymphocyte development" ; oboInOwl:id "GO:0030098" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "lymphocyte differentiation" ; rdfs:subClassOf obo:GO_0046649, obo:GO_1903131 . obo:GO_0030099 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030099" ; a owl:Class ; rdfs:label "myeloid cell differentiation" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030097 ] . obo:GO_0030100 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of endocytosis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030100" ; a owl:Class ; rdfs:label "regulation of endocytosis" ; rdfs:subClassOf obo:GO_0051128, obo:GO_0060627, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006897 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006897 ] ) ] . obo:GO_0030103 obo:IAO_0000115 "The regulated release of vasopressin from secretory granules into the blood." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030103" ; a owl:Class ; rdfs:label "vasopressin secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0030141 obo:IAO_0000115 "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." ; obo:RO_0002161 obo:NCBITaxon_4890 ; oboInOwl:hasBroadSynonym "secretory vesicle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030141" ; a owl:Class ; rdfs:comment "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'." ; rdfs:label "secretory granule" ; rdfs:subClassOf obo:GO_0099503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0012505 ] . obo:GO_0030154 obo:IAO_0000115 "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24390"^^xsd:anyURI ; oboInOwl:hasDbXref "Wikipedia:Cellular_differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030154" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_mouse, go:goslim_plant ; a owl:Class ; rdfs:label "cell differentiation" ; rdfs:subClassOf obo:GO_0048869 . obo:GO_0030155 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell adhesion receptor regulator activity" ; oboInOwl:id "GO:0030155" ; a owl:Class ; rdfs:label "regulation of cell adhesion" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007155 ] ) ] . obo:GO_0030162 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." ; oboInOwl:hasExactSynonym "regulation of peptidolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030162" ; a owl:Class ; rdfs:label "regulation of proteolysis" ; rdfs:subClassOf obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006508 ] ) ] . obo:GO_0030168 obo:IAO_0000115 "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." ; oboInOwl:hasExactSynonym "blood coagulation, platelet activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030168" ; a owl:Class ; rdfs:label "platelet activation" ; rdfs:subClassOf obo:GO_0001775, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007596 ] . obo:GO_0030183 obo:IAO_0000115 "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." ; oboInOwl:hasAlternativeId "GO:0042115" ; oboInOwl:hasExactSynonym "B lymphocyte differentiation", "B-cell differentiation", "B-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "B cell development" ; oboInOwl:id "GO:0030183" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "B cell differentiation" ; rdfs:subClassOf obo:GO_0030098, obo:GO_0042113 . obo:GO_0030186 obo:IAO_0000115 "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." ; oboInOwl:hasExactSynonym "melatonin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030186" ; a owl:Class ; rdfs:label "melatonin metabolic process" ; rdfs:subClassOf obo:GO_0042430, obo:GO_0042445, obo:GO_0043603 . obo:GO_0030187 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." ; oboInOwl:hasExactSynonym "melatonin anabolism", "melatonin biosynthesis", "melatonin formation", "melatonin synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030187" ; a owl:Class ; rdfs:label "melatonin biosynthetic process" ; rdfs:subClassOf obo:GO_0030186, obo:GO_0042435, obo:GO_0042446, obo:GO_0043604 . obo:GO_0030193 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood coagulation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030193" ; a owl:Class ; rdfs:label "regulation of blood coagulation" ; rdfs:subClassOf obo:GO_0032101, obo:GO_0050818, obo:GO_0061041, obo:GO_1900046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007596 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:GO_0030194 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood coagulation." ; oboInOwl:hasExactSynonym "up regulation of blood coagulation", "up-regulation of blood coagulation", "upregulation of blood coagulation" ; oboInOwl:hasNarrowSynonym "activation of blood coagulation", "stimulation of blood coagulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030194" ; a owl:Class ; rdfs:label "positive regulation of blood coagulation" ; rdfs:subClassOf obo:GO_0030193, obo:GO_0050820, obo:GO_0090303, obo:GO_1900048, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007596 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:GO_0030195 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." ; oboInOwl:hasExactSynonym "down regulation of blood coagulation", "down-regulation of blood coagulation", "downregulation of blood coagulation" ; oboInOwl:hasNarrowSynonym "inhibition of blood coagulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030195" ; a owl:Class ; rdfs:label "negative regulation of blood coagulation" ; rdfs:subClassOf obo:GO_0030193, obo:GO_0050819, obo:GO_0061045, obo:GO_1900047, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007596 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:GO_0030198 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." ; oboInOwl:hasExactSynonym "extracellular matrix organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "extracellular matrix organization and biogenesis" ; oboInOwl:id "GO:0030198" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic ; a owl:Class ; rdfs:label "extracellular matrix organization" ; rdfs:subClassOf obo:GO_0043062, obo:GO_0045229 . obo:GO_0030202 obo:IAO_0000115 "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." ; oboInOwl:hasExactSynonym "heparin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "heparan sulfate metabolic process" ; oboInOwl:id "GO:0030202" ; a owl:Class ; rdfs:label "heparin metabolic process" ; rdfs:subClassOf obo:GO_0006790, obo:GO_1903510 . obo:GO_0030203 obo:IAO_0000115 "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." ; oboInOwl:hasExactSynonym "glycosaminoglycan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030203" ; a owl:Class ; rdfs:label "glycosaminoglycan metabolic process" ; rdfs:subClassOf obo:GO_0006022 . obo:GO_0030210 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." ; oboInOwl:hasExactSynonym "heparin anabolism", "heparin biosynthesis", "heparin formation", "heparin synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "heparan sulfate biosynthetic process" ; oboInOwl:id "GO:0030210" ; a owl:Class ; rdfs:label "heparin biosynthetic process" ; rdfs:subClassOf obo:GO_0006024, obo:GO_0030202, obo:GO_0044272 . obo:GO_0030216 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." ; oboInOwl:hasExactSynonym "keratinocyte cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030216" ; a owl:Class ; rdfs:label "keratinocyte differentiation" ; rdfs:subClassOf obo:GO_0009913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043588 ] . obo:GO_0030217 obo:IAO_0000115 "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." ; oboInOwl:hasAlternativeId "GO:0042112", "GO:0046652" ; oboInOwl:hasExactSynonym "T lymphocyte differentiation", "T-cell differentiation", "T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "T cell development" ; oboInOwl:id "GO:0030217" ; a owl:Class ; rdfs:comment "Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "T cell differentiation" ; rdfs:subClassOf obo:GO_0030098, obo:GO_0042110 . obo:GO_0030218 obo:IAO_0000115 "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." ; oboInOwl:hasDbXref "Wikipedia:Erythropoiesis" ; oboInOwl:hasExactSynonym "RBC differentiation", "erythrocyte cell differentiation", "erythropoiesis", "red blood cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030218" ; a owl:Class ; rdfs:label "erythrocyte differentiation" ; rdfs:subClassOf obo:GO_0030099, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0034101 ] . obo:GO_0030219 obo:IAO_0000115 "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." ; oboInOwl:hasExactSynonym "megakaryocyte cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030219" ; a owl:Class ; rdfs:label "megakaryocyte differentiation" ; rdfs:subClassOf obo:GO_0030099 . obo:GO_0030221 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." ; oboInOwl:hasExactSynonym "basophil cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030221" ; a owl:Class ; rdfs:label "basophil differentiation" ; rdfs:subClassOf obo:GO_0030851 . obo:GO_0030224 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." ; oboInOwl:hasExactSynonym "monocyte cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030224" ; a owl:Class ; rdfs:label "monocyte differentiation" ; rdfs:subClassOf obo:GO_0002573, obo:GO_1903131 . obo:GO_0030225 obo:IAO_0000115 "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." ; oboInOwl:hasExactSynonym "macrophage cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030225" ; a owl:Class ; rdfs:label "macrophage differentiation" ; rdfs:subClassOf obo:GO_0002573 . obo:GO_0030252 obo:IAO_0000115 "The regulated release of growth hormone from secretory granules into the blood." ; oboInOwl:hasExactSynonym "somatotropin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030252" ; a owl:Class ; rdfs:label "growth hormone secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0030261 obo:IAO_0000115 "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." ; oboInOwl:hasAlternativeId "GO:0000068" ; oboInOwl:hasBroadSynonym "DNA condensation" ; oboInOwl:hasExactSynonym "eukaryotic chromosome condensation", "nuclear chromosome condensation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030261" ; a owl:Class ; rdfs:label "chromosome condensation" ; rdfs:subClassOf obo:GO_0051276 . obo:GO_0030262 obo:IAO_0000115 "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." ; oboInOwl:hasNarrowSynonym "apoptotic nuclear change" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030262" ; a owl:Class ; rdfs:label "apoptotic nuclear changes" ; rdfs:subClassOf obo:GO_0006921 . obo:GO_0030263 obo:IAO_0000115 "The compaction of chromatin during apoptosis." ; oboInOwl:hasDbXref "Wikipedia:Pyknosis" ; oboInOwl:hasExactSynonym "pyknosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030263" ; a owl:Class ; rdfs:label "apoptotic chromosome condensation" ; rdfs:subClassOf obo:GO_0030261, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030262 ] . obo:GO_0030278 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." ; oboInOwl:hasExactSynonym "regulation of bone biosynthesis", "regulation of bone formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030278" ; a owl:Class ; rdfs:label "regulation of ossification" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001503 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001503 ] ) ] . obo:GO_0030279 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." ; oboInOwl:hasExactSynonym "down regulation of ossification", "down-regulation of ossification", "downregulation of ossification", "negative regulation of bone biosynthesis", "negative regulation of bone formation" ; oboInOwl:hasNarrowSynonym "inhibition of ossification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030279" ; a owl:Class ; rdfs:label "negative regulation of ossification" ; rdfs:subClassOf obo:GO_0030278, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001503 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001503 ] ) ] . obo:GO_0030282 obo:IAO_0000115 "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." ; oboInOwl:hasNarrowSynonym "bone calcification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030282" ; a owl:Class ; rdfs:label "bone mineralization" ; rdfs:subClassOf obo:GO_0031214, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001503 ] . obo:GO_0030307 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, extent or direction of cell growth." ; oboInOwl:hasExactSynonym "up regulation of cell growth", "up-regulation of cell growth", "upregulation of cell growth" ; oboInOwl:hasNarrowSynonym "activation of cell growth", "stimulation of cell growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030307" ; a owl:Class ; rdfs:label "positive regulation of cell growth" ; rdfs:subClassOf obo:GO_0001558, obo:GO_0045927, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016049 ] ) ] . obo:GO_0030308 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." ; oboInOwl:hasExactSynonym "down regulation of cell growth", "down-regulation of cell growth", "downregulation of cell growth" ; oboInOwl:hasNarrowSynonym "inhibition of cell growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030308" ; a owl:Class ; rdfs:label "negative regulation of cell growth" ; rdfs:subClassOf obo:GO_0001558, obo:GO_0045926, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016049 ] ) ] . obo:GO_0030312 obo:IAO_0000115 "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030312" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:comment "The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'." ; rdfs:label "external encapsulating structure" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0071944 ] . obo:GO_0030316 obo:IAO_0000115 "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." ; oboInOwl:hasExactSynonym "osteoclast cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030316" ; a owl:Class ; rdfs:label "osteoclast differentiation" ; rdfs:subClassOf obo:GO_0002573 . obo:GO_0030317 obo:IAO_0000115 "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." ; oboInOwl:hasAlternativeId "GO:0097724", "GO:1905419" ; oboInOwl:hasBroadSynonym "sperm motility", "sperm movement" ; oboInOwl:hasDbXref "Wikipedia:Sperm_motility" ; oboInOwl:hasExactSynonym "flagellated sperm movement", "sperm flagellum movement", "sperm flagellum movement involved in flagellated sperm motility", "sperm flagellum movement involved in flagellated sperm movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030317" ; a owl:Class ; rdfs:label "flagellated sperm motility" ; rdfs:subClassOf obo:GO_0060285, obo:GO_0060294, obo:GO_0097722 . obo:GO_0030323 obo:IAO_0000115 "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030323" ; a owl:Class ; rdfs:label "respiratory tube development" ; rdfs:subClassOf obo:GO_0035295, obo:GO_0048513 . obo:GO_0030324 obo:IAO_0000115 "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030324" ; a owl:Class ; rdfs:label "lung development" ; rdfs:subClassOf obo:GO_0048513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030323 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060541 ] . obo:GO_0030334 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell migration." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030334" ; a owl:Class ; rdfs:label "regulation of cell migration" ; rdfs:subClassOf obo:GO_2000145, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016477 ] ) ] . obo:GO_0030335 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell migration." ; oboInOwl:hasExactSynonym "up regulation of cell migration", "up-regulation of cell migration", "upregulation of cell migration" ; oboInOwl:hasNarrowSynonym "activation of cell migration", "stimulation of cell migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030335" ; a owl:Class ; rdfs:label "positive regulation of cell migration" ; rdfs:subClassOf obo:GO_0030334, obo:GO_2000147, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016477 ] ) ] . obo:GO_0030336 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." ; oboInOwl:hasExactSynonym "down regulation of cell migration", "down-regulation of cell migration", "downregulation of cell migration" ; oboInOwl:hasNarrowSynonym "inhibition of cell migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030336" ; a owl:Class ; rdfs:label "negative regulation of cell migration" ; rdfs:subClassOf obo:GO_0030334, obo:GO_2000146, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016477 ] ) ] . obo:GO_0030421 obo:IAO_0000115 "The expulsion of feces from the rectum." ; oboInOwl:hasDbXref "Wikipedia:Defecation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030421" ; a owl:Class ; rdfs:label "defecation" ; rdfs:subClassOf obo:GO_0007588, obo:GO_0022600 . obo:GO_0030424 obo:IAO_0000115 "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1770195789", "Wikipedia:Axon" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030424" ; a owl:Class ; rdfs:label "axon" ; rdfs:subClassOf obo:GO_0043005 . obo:GO_0030425 obo:IAO_0000115 "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1211023249", "Wikipedia:Dendrite" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030425" ; a owl:Class ; rdfs:label "dendrite" ; rdfs:subClassOf obo:GO_0043005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0097447 ] . obo:GO_0030431 obo:IAO_0000115 "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." ; oboInOwl:hasDbXref "Wikipedia:Sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "diapause", "dormancy", "lethargus" ; oboInOwl:id "GO:0030431" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "sleep" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0030432 obo:IAO_0000115 "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." ; oboInOwl:hasDbXref "Wikipedia:Peristalsis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030432" ; a owl:Class ; rdfs:label "peristalsis" ; rdfs:subClassOf obo:GO_0014821 . obo:GO_0030449 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of complement activation." ; oboInOwl:hasExactSynonym "regulation of complement cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030449" ; a owl:Class ; rdfs:label "regulation of complement activation" ; rdfs:subClassOf obo:GO_0002697, obo:GO_0002920, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006956 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006956 ] ) ] . obo:GO_0030500 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bone mineralization." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030500" ; a owl:Class ; rdfs:label "regulation of bone mineralization" ; rdfs:subClassOf obo:GO_0030278, obo:GO_0070167, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030282 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030282 ] ) ] . obo:GO_0030501 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bone mineralization." ; oboInOwl:hasExactSynonym "up regulation of bone mineralization", "up-regulation of bone mineralization", "upregulation of bone mineralization" ; oboInOwl:hasNarrowSynonym "activation of bone mineralization", "stimulation of bone mineralization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030501" ; a owl:Class ; rdfs:label "positive regulation of bone mineralization" ; rdfs:subClassOf obo:GO_0030500, obo:GO_0045778, obo:GO_0070169, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030282 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030282 ] ) ] . obo:GO_0030502 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." ; oboInOwl:hasExactSynonym "down regulation of bone mineralization", "down-regulation of bone mineralization", "downregulation of bone mineralization" ; oboInOwl:hasNarrowSynonym "inhibition of bone mineralization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030502" ; a owl:Class ; rdfs:label "negative regulation of bone mineralization" ; rdfs:subClassOf obo:GO_0030279, obo:GO_0030500, obo:GO_0070168, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030282 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030282 ] ) ] . obo:GO_0030593 obo:IAO_0000115 "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030593" ; a owl:Class ; rdfs:label "neutrophil chemotaxis" ; rdfs:subClassOf obo:GO_0071621, obo:GO_1990266 . obo:GO_0030595 obo:IAO_0000115 "The movement of a leukocyte in response to an external stimulus." ; oboInOwl:hasExactSynonym "immune cell chemotaxis", "leucocyte chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030595" ; a owl:Class ; rdfs:label "leukocyte chemotaxis" ; rdfs:subClassOf obo:GO_0050900, obo:GO_0060326 . obo:GO_0030656 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." ; oboInOwl:hasExactSynonym "regulation of vitamin metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030656" ; a owl:Class ; rdfs:label "regulation of vitamin metabolic process" ; rdfs:subClassOf obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006766 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006766 ] ) ] . obo:GO_0030659 obo:IAO_0000115 "The lipid bilayer surrounding a cytoplasmic vesicle." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030659" ; a owl:Class ; rdfs:label "cytoplasmic vesicle membrane" ; rdfs:subClassOf obo:GO_0012506, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031410 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031410 ] ) ] . obo:GO_0030667 obo:IAO_0000115 "The lipid bilayer surrounding a secretory granule." ; oboInOwl:hasBroadSynonym "secretory vesicle membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030667" ; a owl:Class ; rdfs:label "secretory granule membrane" ; rdfs:subClassOf obo:GO_0030659, obo:GO_0098588, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030141 ] . obo:GO_0030705 obo:IAO_0000115 "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030705" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila ; a owl:Class ; rdfs:label "cytoskeleton-dependent intracellular transport" ; rdfs:subClassOf obo:GO_0046907 . obo:GO_0030851 obo:IAO_0000115 "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." ; oboInOwl:hasExactSynonym "granulocyte cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030851" ; a owl:Class ; rdfs:label "granulocyte differentiation" ; rdfs:subClassOf obo:GO_0002573 . obo:GO_0030852 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of granulocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030852" ; a owl:Class ; rdfs:label "regulation of granulocyte differentiation" ; rdfs:subClassOf obo:GO_0002761, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:GO_0030853 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of granulocyte differentiation", "down-regulation of granulocyte differentiation", "downregulation of granulocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of granulocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030853" ; a owl:Class ; rdfs:label "negative regulation of granulocyte differentiation" ; rdfs:subClassOf obo:GO_0002762, obo:GO_0030852, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:GO_0030854 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of granulocyte differentiation", "up-regulation of granulocyte differentiation", "upregulation of granulocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of granulocyte differentiation", "stimulation of granulocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030854" ; a owl:Class ; rdfs:label "positive regulation of granulocyte differentiation" ; rdfs:subClassOf obo:GO_0002763, obo:GO_0030852, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030851 ] ) ] . obo:GO_0030855 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030855" ; a owl:Class ; rdfs:label "epithelial cell differentiation" ; rdfs:subClassOf obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060429 ] . obo:GO_0030856 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030856" ; a owl:Class ; rdfs:label "regulation of epithelial cell differentiation" ; rdfs:subClassOf obo:GO_0045595, obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030855 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030855 ] ) ] . obo:GO_0030857 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of epithelial cell differentiation", "down-regulation of epithelial cell differentiation", "downregulation of epithelial cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of epithelial cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030857" ; a owl:Class ; rdfs:label "negative regulation of epithelial cell differentiation" ; rdfs:subClassOf obo:GO_0030856, obo:GO_0045596, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030855 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030855 ] ) ] . obo:GO_0030858 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." ; oboInOwl:hasExactSynonym "up regulation of epithelial cell differentiation", "up-regulation of epithelial cell differentiation", "upregulation of epithelial cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of epithelial cell differentiation", "stimulation of epithelial cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030858" ; a owl:Class ; rdfs:label "positive regulation of epithelial cell differentiation" ; rdfs:subClassOf obo:GO_0030856, obo:GO_0045597, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030855 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030855 ] ) ] . obo:GO_0030879 obo:IAO_0000115 "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." ; oboInOwl:hasNarrowSynonym "mammogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030879" ; a owl:Class ; rdfs:label "mammary gland development" ; rdfs:subClassOf obo:GO_0048732 . obo:GO_0030885 obo:IAO_0000115 "Any process that modulates the frequency or rate of myeloid dendritic cell activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030885" ; a owl:Class ; rdfs:label "regulation of myeloid dendritic cell activation" ; rdfs:subClassOf obo:GO_0002694, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001773 ] ) ] . obo:GO_0030886 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." ; oboInOwl:hasExactSynonym "down regulation of myeloid dendritic cell activation", "down-regulation of myeloid dendritic cell activation", "downregulation of myeloid dendritic cell activation" ; oboInOwl:hasNarrowSynonym "inhibition of myeloid dendritic cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030886" ; a owl:Class ; rdfs:label "negative regulation of myeloid dendritic cell activation" ; rdfs:subClassOf obo:GO_0002695, obo:GO_0030885, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001773 ] ) ] . obo:GO_0030887 obo:IAO_0000115 "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." ; oboInOwl:hasExactSynonym "up regulation of myeloid dendritic cell activation", "up-regulation of myeloid dendritic cell activation", "upregulation of myeloid dendritic cell activation" ; oboInOwl:hasNarrowSynonym "activation of myeloid dendritic cell activation", "stimulation of myeloid dendritic cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030887" ; a owl:Class ; rdfs:label "positive regulation of myeloid dendritic cell activation" ; rdfs:subClassOf obo:GO_0002696, obo:GO_0030885, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001773 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001773 ] ) ] . obo:GO_0030888 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of B cell proliferation." ; oboInOwl:hasExactSynonym "regulation of B lymphocyte proliferation", "regulation of B-cell proliferation", "regulation of B-lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030888" ; a owl:Class ; rdfs:label "regulation of B cell proliferation" ; rdfs:subClassOf obo:GO_0050670, obo:GO_0050864, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042100 ] ) ] . obo:GO_0030889 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." ; oboInOwl:hasExactSynonym "down regulation of B cell proliferation", "down-regulation of B cell proliferation", "downregulation of B cell proliferation", "negative regulation of B lymphocyte proliferation", "negative regulation of B-cell proliferation", "negative regulation of B-lymphocyte proliferation" ; oboInOwl:hasNarrowSynonym "inhibition of B cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030889" ; a owl:Class ; rdfs:label "negative regulation of B cell proliferation" ; rdfs:subClassOf obo:GO_0030888, obo:GO_0050672, obo:GO_0050869, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042100 ] ) ] . obo:GO_0030890 obo:IAO_0000115 "Any process that activates or increases the rate or extent of B cell proliferation." ; oboInOwl:hasExactSynonym "positive regulation of B lymphocyte proliferation", "positive regulation of B-cell proliferation", "positive regulation of B-lymphocyte proliferation", "up regulation of B cell proliferation", "up-regulation of B cell proliferation", "upregulation of B cell proliferation" ; oboInOwl:hasNarrowSynonym "activation of B cell proliferation", "stimulation of B cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0030890" ; a owl:Class ; rdfs:label "positive regulation of B cell proliferation" ; rdfs:subClassOf obo:GO_0030888, obo:GO_0050671, obo:GO_0050871, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042100 ] ) ] . obo:GO_0030936 obo:IAO_0000115 "Any collagen trimer that passes through a lipid bilayer membrane." ; oboInOwl:hasExactSynonym "MACIT" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0030936" ; a owl:Class ; rdfs:label "transmembrane collagen trimer" ; rdfs:subClassOf obo:GO_0005581, obo:GO_0098797 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005581 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ) ] . obo:GO_0030990 obo:IAO_0000115 "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." ; oboInOwl:hasExactSynonym "intraflagellar transport complex", "intraflagellar transport particle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "IFT complex" ; oboInOwl:id "GO:0030990" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:comment "Note that we deem cilia and microtubule-based flagella to be equivalent." ; rdfs:label "intraciliary transport particle" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0031012 obo:IAO_0000115 "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." ; oboInOwl:hasAlternativeId "GO:0005578" ; oboInOwl:hasDbXref "NIF_Subcellular:nlx_subcell_20090513", "Wikipedia:Extracellular_matrix" ; oboInOwl:hasExactSynonym "proteinaceous extracellular matrix" ; oboInOwl:hasNarrowSynonym "matrisome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031012" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:label "extracellular matrix" ; rdfs:subClassOf obo:GO_0030312 . obo:GO_0031049 obo:IAO_0000115 "A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22815"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031049" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "programmed DNA elimination" ; rdfs:subClassOf obo:GO_0040029 . obo:GO_0031052 obo:IAO_0000115 "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22815"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chromosome breakage" ; oboInOwl:id "GO:0031052" ; a owl:Class ; rdfs:comment "Note that this term refers to breakage of chromosomes during normal DNA well characterized in ciliates but also present in many vertebrates; it is not to be used for DNA damage or other abnormal occurrences." ; rdfs:label "programmed DNA elimination by chromosome breakage" ; rdfs:subClassOf obo:GO_0031049 . obo:GO_0031090 obo:IAO_0000115 "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." ; oboInOwl:hasDbXref "NIF_Subcellular:sao830981606" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "intracellular membrane" ; oboInOwl:id "GO:0031090" ; a owl:Class ; rdfs:label "organelle membrane" ; rdfs:subClassOf obo:GO_0016020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043227 ] ) ] . obo:GO_0031099 obo:IAO_0000115 "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." ; oboInOwl:hasDbXref "Wikipedia:Regeneration_(biology)" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031099" ; a owl:Class ; rdfs:label "regeneration" ; rdfs:subClassOf obo:GO_0048856 . obo:GO_0031214 obo:IAO_0000115 "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." ; oboInOwl:hasDbXref "Wikipedia:Biomineralization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031214" ; a owl:Class ; rdfs:label "biomineral tissue development" ; rdfs:subClassOf obo:GO_0009888, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048513 ] . obo:GO_0031268 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." ; oboInOwl:hasExactSynonym "pseudopodium organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pseudopodium organization and biogenesis" ; oboInOwl:id "GO:0031268" ; a owl:Class ; rdfs:label "pseudopodium organization" ; rdfs:subClassOf obo:GO_0120036 . obo:GO_0031323 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." ; oboInOwl:hasExactSynonym "regulation of cellular metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031323" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of cellular metabolic process" ; rdfs:subClassOf obo:GO_0019222, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044237 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044237 ] ) ] . obo:GO_0031324 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." ; oboInOwl:hasExactSynonym "down regulation of cellular metabolic process", "down-regulation of cellular metabolic process", "downregulation of cellular metabolic process", "negative regulation of cellular metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of cellular metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031324" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of cellular metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0031323, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044237 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044237 ] ) ] . obo:GO_0031325 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." ; oboInOwl:hasExactSynonym "positive regulation of cellular metabolism", "up regulation of cellular metabolic process", "up-regulation of cellular metabolic process", "upregulation of cellular metabolic process" ; oboInOwl:hasNarrowSynonym "activation of cellular metabolic process", "stimulation of cellular metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031325" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of cellular metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0031323, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044237 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044237 ] ) ] . obo:GO_0031326 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "regulation of cellular anabolism", "regulation of cellular biosynthesis", "regulation of cellular formation", "regulation of cellular synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031326" ; a owl:Class ; rdfs:label "regulation of cellular biosynthetic process" ; rdfs:subClassOf obo:GO_0009889, obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044249 ] ) ] . obo:GO_0031327 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "down regulation of cellular biosynthetic process", "down-regulation of cellular biosynthetic process", "downregulation of cellular biosynthetic process", "negative regulation of cellular anabolism", "negative regulation of cellular biosynthesis", "negative regulation of cellular formation", "negative regulation of cellular synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of cellular biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031327" ; a owl:Class ; rdfs:label "negative regulation of cellular biosynthetic process" ; rdfs:subClassOf obo:GO_0009890, obo:GO_0031324, obo:GO_0031326, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044249 ] ) ] . obo:GO_0031328 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "positive regulation of cellular anabolism", "positive regulation of cellular biosynthesis", "positive regulation of cellular formation", "positive regulation of cellular synthesis", "up regulation of cellular biosynthetic process", "up-regulation of cellular biosynthetic process", "upregulation of cellular biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of cellular biosynthetic process", "stimulation of cellular biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031328" ; a owl:Class ; rdfs:label "positive regulation of cellular biosynthetic process" ; rdfs:subClassOf obo:GO_0009891, obo:GO_0031325, obo:GO_0031326, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044249 ] ) ] . obo:GO_0031329 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "regulation of cellular breakdown", "regulation of cellular catabolism", "regulation of cellular degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031329" ; a owl:Class ; rdfs:label "regulation of cellular catabolic process" ; rdfs:subClassOf obo:GO_0009894, obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044248 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044248 ] ) ] . obo:GO_0031330 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "down regulation of cellular catabolic process", "down-regulation of cellular catabolic process", "downregulation of cellular catabolic process", "negative regulation of cellular breakdown", "negative regulation of cellular catabolism", "negative regulation of cellular degradation" ; oboInOwl:hasNarrowSynonym "inhibition of cellular catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031330" ; a owl:Class ; rdfs:label "negative regulation of cellular catabolic process" ; rdfs:subClassOf obo:GO_0009895, obo:GO_0031324, obo:GO_0031329, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044248 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044248 ] ) ] . obo:GO_0031331 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "positive regulation of cellular breakdown", "positive regulation of cellular catabolism", "positive regulation of cellular degradation", "up regulation of cellular catabolic process", "up-regulation of cellular catabolic process", "upregulation of cellular catabolic process" ; oboInOwl:hasNarrowSynonym "activation of cellular catabolic process", "stimulation of cellular catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031331" ; a owl:Class ; rdfs:label "positive regulation of cellular catabolic process" ; rdfs:subClassOf obo:GO_0009896, obo:GO_0031325, obo:GO_0031329, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044248 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044248 ] ) ] . obo:GO_0031335 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." ; oboInOwl:hasExactSynonym "regulation of sulfur amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031335" ; a owl:Class ; rdfs:label "regulation of sulfur amino acid metabolic process" ; rdfs:subClassOf obo:GO_0042762, obo:GO_0051171, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000096 ] ) ] . obo:GO_0031336 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." ; oboInOwl:hasExactSynonym "down regulation of sulfur amino acid metabolic process", "down-regulation of sulfur amino acid metabolic process", "downregulation of sulfur amino acid metabolic process", "negative regulation of sulfur amino acid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of sulfur amino acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031336" ; a owl:Class ; rdfs:label "negative regulation of sulfur amino acid metabolic process" ; rdfs:subClassOf obo:GO_0031335, obo:GO_0051172, obo:GO_0051175, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000096 ] ) ] . obo:GO_0031337 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." ; oboInOwl:hasExactSynonym "positive regulation of sulfur amino acid metabolism", "up regulation of sulfur amino acid metabolic process", "up-regulation of sulfur amino acid metabolic process", "upregulation of sulfur amino acid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of sulfur amino acid metabolic process", "stimulation of sulfur amino acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031337" ; a owl:Class ; rdfs:label "positive regulation of sulfur amino acid metabolic process" ; rdfs:subClassOf obo:GO_0031335, obo:GO_0051173, obo:GO_0051176, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000096 ] ) ] . obo:GO_0031338 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of vesicle fusion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031338" ; a owl:Class ; rdfs:label "regulation of vesicle fusion" ; rdfs:subClassOf obo:GO_0033043, obo:GO_0060627, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006906 ] ) ] . obo:GO_0031339 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." ; oboInOwl:hasExactSynonym "down regulation of vesicle fusion", "down-regulation of vesicle fusion", "downregulation of vesicle fusion" ; oboInOwl:hasNarrowSynonym "inhibition of vesicle fusion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031339" ; a owl:Class ; rdfs:label "negative regulation of vesicle fusion" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0031338, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006906 ] ) ] . obo:GO_0031340 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of vesicle fusion." ; oboInOwl:hasExactSynonym "up regulation of vesicle fusion", "up-regulation of vesicle fusion", "upregulation of vesicle fusion" ; oboInOwl:hasNarrowSynonym "activation of vesicle fusion", "stimulation of vesicle fusion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031340" ; a owl:Class ; rdfs:label "positive regulation of vesicle fusion" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0031338, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006906 ] ) ] . obo:GO_0031341 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031341" ; a owl:Class ; rdfs:label "regulation of cell killing" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001906 ] ) ] . obo:GO_0031342 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." ; oboInOwl:hasExactSynonym "down regulation of cell killing", "down-regulation of cell killing", "downregulation of cell killing" ; oboInOwl:hasNarrowSynonym "inhibition of cell killing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031342" ; a owl:Class ; rdfs:label "negative regulation of cell killing" ; rdfs:subClassOf obo:GO_0031341, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001906 ] ) ] . obo:GO_0031343 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell killing." ; oboInOwl:hasExactSynonym "up regulation of cell killing", "up-regulation of cell killing", "upregulation of cell killing" ; oboInOwl:hasNarrowSynonym "activation of cell killing", "stimulation of cell killing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031343" ; a owl:Class ; rdfs:label "positive regulation of cell killing" ; rdfs:subClassOf obo:GO_0031341, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001906 ] ) ] . obo:GO_0031344 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." ; oboInOwl:hasExactSynonym "regulation of cell projection organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cell projection organization and biogenesis" ; oboInOwl:id "GO:0031344" ; a owl:Class ; rdfs:label "regulation of cell projection organization" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030030 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030030 ] ) ] . obo:GO_0031345 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." ; oboInOwl:hasExactSynonym "down regulation of cell projection organization", "down-regulation of cell projection organization", "downregulation of cell projection organization", "negative regulation of cell projection organisation" ; oboInOwl:hasNarrowSynonym "inhibition of cell projection organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cell projection organization and biogenesis" ; oboInOwl:id "GO:0031345" ; a owl:Class ; rdfs:label "negative regulation of cell projection organization" ; rdfs:subClassOf obo:GO_0031344, obo:GO_0051129, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030030 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030030 ] ) ] . obo:GO_0031346 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." ; oboInOwl:hasExactSynonym "positive regulation of cell projection organisation", "up regulation of cell projection organization", "up-regulation of cell projection organization", "upregulation of cell projection organization" ; oboInOwl:hasNarrowSynonym "activation of cell projection organization", "stimulation of cell projection organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cell projection organization and biogenesis" ; oboInOwl:id "GO:0031346" ; a owl:Class ; rdfs:label "positive regulation of cell projection organization" ; rdfs:subClassOf obo:GO_0031344, obo:GO_0051130, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030030 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030030 ] ) ] . obo:GO_0031347 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a defense response." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031347" ; a owl:Class ; rdfs:label "regulation of defense response" ; rdfs:subClassOf obo:GO_0080134, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006952 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006952 ] ) ] . obo:GO_0031348 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." ; oboInOwl:hasExactSynonym "down regulation of defense response", "down-regulation of defense response", "downregulation of defense response" ; oboInOwl:hasNarrowSynonym "inhibition of defense response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031348" ; a owl:Class ; rdfs:label "negative regulation of defense response" ; rdfs:subClassOf obo:GO_0031347, obo:GO_0048585, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006952 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006952 ] ) ] . obo:GO_0031349 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a defense response." ; oboInOwl:hasExactSynonym "up regulation of defense response", "up-regulation of defense response", "upregulation of defense response" ; oboInOwl:hasNarrowSynonym "activation of defense response", "stimulation of defense response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031349" ; a owl:Class ; rdfs:label "positive regulation of defense response" ; rdfs:subClassOf obo:GO_0031347, obo:GO_0048584, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006952 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006952 ] ) ] . obo:GO_0031399 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031399" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of protein modification process" ; rdfs:subClassOf obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0036211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0036211 ] ) ] . obo:GO_0031400 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." ; oboInOwl:hasExactSynonym "down regulation of protein modification", "down-regulation of protein modification", "downregulation of protein modification" ; oboInOwl:hasNarrowSynonym "inhibition of protein modification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031400" ; a owl:Class ; rdfs:label "negative regulation of protein modification process" ; rdfs:subClassOf obo:GO_0031399, obo:GO_0051248, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0036211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0036211 ] ) ] . obo:GO_0031401 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." ; oboInOwl:hasExactSynonym "up regulation of protein modification", "up-regulation of protein modification", "upregulation of protein modification" ; oboInOwl:hasNarrowSynonym "activation of protein modification", "stimulation of protein modification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031401" ; a owl:Class ; rdfs:label "positive regulation of protein modification process" ; rdfs:subClassOf obo:GO_0031399, obo:GO_0051247, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0036211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0036211 ] ) ] . obo:GO_0031410 obo:IAO_0000115 "A vesicle found in the cytoplasm of a cell." ; oboInOwl:hasAlternativeId "GO:0016023" ; oboInOwl:hasDbXref "NIF_Subcellular:sao180601769" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "cytoplasmic membrane bounded vesicle", "cytoplasmic membrane-enclosed vesicle", "cytoplasmic, membrane-bounded vesicle" ; oboInOwl:id "GO:0031410" ; oboInOwl:inSubset go:goslim_agr, go:goslim_candida, go:goslim_chembl, go:goslim_generic, go:goslim_mouse, go:goslim_yeast ; a owl:Class ; rdfs:label "cytoplasmic vesicle" ; rdfs:subClassOf obo:GO_0097708, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] ) ] . obo:GO_0031424 obo:IAO_0000115 "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031424" ; a owl:Class ; rdfs:label "keratinization" ; rdfs:subClassOf obo:GO_0032501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030216 ] . obo:GO_0031503 obo:IAO_0000115 "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0034629" ; oboInOwl:hasExactSynonym "establishment and maintenance of protein complex localization", "protein complex localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cellular protein complex localisation", "cellular protein complex localization", "cellular protein-containing complex localization", "establishment and maintenance of cellular protein complex localization", "protein complex localization" ; oboInOwl:id "GO:0031503" ; a owl:Class ; rdfs:label "protein-containing complex localization" ; rdfs:subClassOf obo:GO_0051179 . obo:GO_0031514 obo:IAO_0000115 "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." ; oboInOwl:hasAlternativeId "GO:0009434", "GO:0031512" ; oboInOwl:hasExactSynonym "motile cilia" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "microtubule-based flagellum", "motile primary cilia", "motile primary cilium", "motile secondary cilium", "nodal cilium" ; oboInOwl:id "GO:0031514" ; a owl:Class ; rdfs:label "motile cilium" ; rdfs:subClassOf obo:GO_0005929 . obo:GO_0031594 obo:IAO_0000115 "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1124888485", "Wikipedia:Neuromuscular_junction" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "NMJ", "motor endplate" ; oboInOwl:id "GO:0031594" ; a owl:Class ; rdfs:comment "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT." ; rdfs:label "neuromuscular junction" ; rdfs:subClassOf obo:GO_0045202 . obo:GO_0031640 obo:IAO_0000115 "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." ; oboInOwl:hasAlternativeId "GO:0001908" ; oboInOwl:hasExactSynonym "killing of cells of other organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031640" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "killing of cells of another organism" ; rdfs:subClassOf obo:GO_0001906, obo:GO_0141061 . obo:GO_0031641 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031641" ; a owl:Class ; rdfs:label "regulation of myelination" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0051960, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042552 ] ) ] . obo:GO_0031642 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." ; oboInOwl:hasExactSynonym "down regulation of myelination", "down-regulation of myelination", "downregulation of myelination" ; oboInOwl:hasNarrowSynonym "inhibition of myelination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031642" ; a owl:Class ; rdfs:label "negative regulation of myelination" ; rdfs:subClassOf obo:GO_0031641, obo:GO_0031645, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042552 ] ) ] . obo:GO_0031643 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." ; oboInOwl:hasExactSynonym "up regulation of myelination", "up-regulation of myelination", "upregulation of myelination" ; oboInOwl:hasNarrowSynonym "activation of myelination", "stimulation of myelination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031643" ; a owl:Class ; rdfs:label "positive regulation of myelination" ; rdfs:subClassOf obo:GO_0031641, obo:GO_0031646, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042552 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042552 ] ) ] . obo:GO_0031644 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." ; oboInOwl:hasExactSynonym "regulation of neurological process", "regulation of neurological system process", "regulation of neurophysiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031644" ; a owl:Class ; rdfs:label "regulation of nervous system process" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050877 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050877 ] ) ] . obo:GO_0031645 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." ; oboInOwl:hasExactSynonym "down regulation of neurological process", "down-regulation of neurological process", "downregulation of neurological process", "negative regulation of neurological process", "negative regulation of neurological system process", "negative regulation of neurophysiological process" ; oboInOwl:hasNarrowSynonym "inhibition of neurological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031645" ; a owl:Class ; rdfs:label "negative regulation of nervous system process" ; rdfs:subClassOf obo:GO_0031644, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050877 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050877 ] ) ] . obo:GO_0031646 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." ; oboInOwl:hasExactSynonym "positive regulation of neurological process", "positive regulation of neurological system process", "positive regulation of neurophysiological process", "up regulation of neurological process", "up-regulation of neurological process", "upregulation of neurological process" ; oboInOwl:hasNarrowSynonym "activation of neurological process", "stimulation of neurological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031646" ; a owl:Class ; rdfs:label "positive regulation of nervous system process" ; rdfs:subClassOf obo:GO_0031644, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050877 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050877 ] ) ] . obo:GO_0031667 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031667" ; a owl:Class ; rdfs:label "response to nutrient levels" ; rdfs:subClassOf obo:GO_0009991 . obo:GO_0031943 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." ; oboInOwl:hasExactSynonym "regulation of glucocorticoid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031943" ; a owl:Class ; rdfs:label "regulation of glucocorticoid metabolic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0031323, obo:GO_0032350, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008211 ] ) ] . obo:GO_0031944 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." ; oboInOwl:hasExactSynonym "down regulation of glucocorticoid metabolic process", "down-regulation of glucocorticoid metabolic process", "downregulation of glucocorticoid metabolic process", "negative regulation of glucocorticoid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of glucocorticoid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031944" ; a owl:Class ; rdfs:label "negative regulation of glucocorticoid metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0031943, obo:GO_0032351, obo:GO_0045939, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008211 ] ) ] . obo:GO_0031945 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." ; oboInOwl:hasExactSynonym "positive regulation of glucocorticoid metabolism", "up regulation of glucocorticoid metabolic process", "up-regulation of glucocorticoid metabolic process", "upregulation of glucocorticoid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of glucocorticoid metabolic process", "stimulation of glucocorticoid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031945" ; a owl:Class ; rdfs:label "positive regulation of glucocorticoid metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0031943, obo:GO_0032352, obo:GO_0045940, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008211 ] ) ] . obo:GO_0031946 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031946" ; a owl:Class ; rdfs:label "regulation of glucocorticoid biosynthetic process" ; rdfs:subClassOf obo:GO_0031943, obo:GO_0090030, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006704 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006704 ] ) ] . obo:GO_0031947 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." ; oboInOwl:hasExactSynonym "down regulation of glucocorticoid biosynthetic process", "down-regulation of glucocorticoid biosynthetic process", "downregulation of glucocorticoid biosynthetic process" ; oboInOwl:hasNarrowSynonym "inhibition of glucocorticoid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031947" ; a owl:Class ; rdfs:label "negative regulation of glucocorticoid biosynthetic process" ; rdfs:subClassOf obo:GO_0031944, obo:GO_0031946, obo:GO_0090032, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006704 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006704 ] ) ] . obo:GO_0031948 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." ; oboInOwl:hasExactSynonym "up regulation of glucocorticoid biosynthetic process", "up-regulation of glucocorticoid biosynthetic process", "upregulation of glucocorticoid biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of glucocorticoid biosynthetic process", "stimulation of glucocorticoid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031948" ; a owl:Class ; rdfs:label "positive regulation of glucocorticoid biosynthetic process" ; rdfs:subClassOf obo:GO_0031945, obo:GO_0031946, obo:GO_0090031, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006704 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006704 ] ) ] . obo:GO_0031965 obo:IAO_0000115 "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1687101204" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031965" ; a owl:Class ; rdfs:label "nuclear membrane" ; rdfs:subClassOf obo:GO_0031090, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ) ] . obo:GO_0031966 obo:IAO_0000115 "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1045389829" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031966" ; a owl:Class ; rdfs:label "mitochondrial membrane" ; rdfs:subClassOf obo:GO_0031090, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005740 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0031967 obo:IAO_0000115 "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031967" ; oboInOwl:inSubset go:goslim_mouse ; a owl:Class ; rdfs:label "organelle envelope" ; rdfs:subClassOf obo:GO_0031975, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043227 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043229 ] . obo:GO_0031974 obo:IAO_0000115 "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031974" ; a owl:Class ; rdfs:label "membrane-enclosed lumen" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0031975 obo:IAO_0000115 "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031975" ; a owl:Class ; rdfs:label "envelope" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0031981 obo:IAO_0000115 "The volume enclosed by the nuclear inner membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0031981" ; a owl:Class ; rdfs:label "nuclear lumen" ; rdfs:subClassOf obo:GO_0070013, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] . obo:GO_0031982 obo:IAO_0000115 "Any small, fluid-filled, spherical organelle enclosed by membrane." ; oboInOwl:hasAlternativeId "GO:0031988" ; oboInOwl:hasDbXref "NIF_Subcellular:sao221389602", "Wikipedia:Vesicle_(biology)" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "membrane-bounded vesicle", "membrane-enclosed vesicle" ; oboInOwl:id "GO:0031982" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "vesicle" ; rdfs:subClassOf obo:GO_0043227 . obo:GO_0031987 obo:IAO_0000115 "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." ; oboInOwl:hasExactSynonym "locomotion during locomotory behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0031987" ; a owl:Class ; rdfs:label "locomotion involved in locomotory behavior" ; rdfs:subClassOf obo:GO_0040011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007626 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0040011 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007626 ] ) ] . obo:GO_0032024 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." ; oboInOwl:hasExactSynonym "up regulation of insulin secretion", "up-regulation of insulin secretion", "upregulation of insulin secretion" ; oboInOwl:hasNarrowSynonym "activation of insulin secretion", "stimulation of insulin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032024" ; a owl:Class ; rdfs:label "positive regulation of insulin secretion" ; rdfs:subClassOf obo:GO_0050714, obo:GO_0050796, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:GO_0032042 obo:IAO_0000115 "The chemical reactions and pathways involving mitochondrial DNA." ; oboInOwl:hasExactSynonym "mitochondrial DNA metabolism", "mtDNA metabolic process", "mtDNA metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032042" ; a owl:Class ; rdfs:label "mitochondrial DNA metabolic process" ; rdfs:subClassOf obo:GO_0006259, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000002 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006259 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0032055 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." ; oboInOwl:hasExactSynonym "down regulation of translation in response to stress", "down-regulation of translation in response to stress", "downregulation of translation in response to stress" ; oboInOwl:hasNarrowSynonym "inhibition of translation in response to stress" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032055" ; a owl:Class ; rdfs:label "negative regulation of translation in response to stress" ; rdfs:subClassOf obo:GO_0017148, obo:GO_0043555 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0033554 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0032056 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." ; oboInOwl:hasExactSynonym "up regulation of translation in response to stress", "up-regulation of translation in response to stress", "upregulation of translation in response to stress" ; oboInOwl:hasNarrowSynonym "activation of translation in response to stress", "stimulation of translation in response to stress" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032056" ; a owl:Class ; rdfs:label "positive regulation of translation in response to stress" ; rdfs:subClassOf obo:GO_0043555, obo:GO_0045727 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0033554 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0032060 obo:IAO_0000115 "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." ; oboInOwl:hasBroadSynonym "blebbing", "membrane blebbing" ; oboInOwl:hasExactSynonym "cell blebbing", "plasma membrane bleb assembly", "plasma membrane blebbing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032060" ; a owl:Class ; rdfs:label "bleb assembly" ; rdfs:subClassOf obo:GO_0120031 . obo:GO_0032098 obo:IAO_0000115 "Any process which modulates appetite, the desire or physical craving for food." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of hunger" ; oboInOwl:id "GO:0032098" ; a owl:Class ; rdfs:label "regulation of appetite" ; rdfs:subClassOf obo:GO_0065008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031667 ] . obo:GO_0032101 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a response to an external stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032101" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "regulation of response to external stimulus" ; rdfs:subClassOf obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009605 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009605 ] ) ] . obo:GO_0032102 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." ; oboInOwl:hasExactSynonym "down regulation of response to external stimulus", "down-regulation of response to external stimulus", "downregulation of response to external stimulus" ; oboInOwl:hasNarrowSynonym "inhibition of response to external stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032102" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "negative regulation of response to external stimulus" ; rdfs:subClassOf obo:GO_0032101, obo:GO_0048585, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009605 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009605 ] ) ] . obo:GO_0032103 obo:IAO_0000115 "Any process that activates, maintains or increases the rate of a response to an external stimulus." ; oboInOwl:hasExactSynonym "up regulation of response to external stimulus", "up-regulation of response to external stimulus", "upregulation of response to external stimulus" ; oboInOwl:hasNarrowSynonym "activation of response to external stimulus", "stimulation of response to external stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032103" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "positive regulation of response to external stimulus" ; rdfs:subClassOf obo:GO_0032101, obo:GO_0048584, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009605 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009605 ] ) ] . obo:GO_0032104 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032104" ; a owl:Class ; rdfs:label "regulation of response to extracellular stimulus" ; rdfs:subClassOf obo:GO_0032101, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009991 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009991 ] ) ] . obo:GO_0032105 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." ; oboInOwl:hasExactSynonym "down regulation of response to extracellular stimulus", "down-regulation of response to extracellular stimulus", "downregulation of response to extracellular stimulus" ; oboInOwl:hasNarrowSynonym "inhibition of response to extracellular stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032105" ; a owl:Class ; rdfs:label "negative regulation of response to extracellular stimulus" ; rdfs:subClassOf obo:GO_0032102, obo:GO_0032104, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009991 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009991 ] ) ] . obo:GO_0032106 obo:IAO_0000115 "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." ; oboInOwl:hasExactSynonym "up regulation of response to extracellular stimulus", "up-regulation of response to extracellular stimulus", "upregulation of response to extracellular stimulus" ; oboInOwl:hasNarrowSynonym "activation of response to extracellular stimulus", "stimulation of response to extracellular stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032106" ; a owl:Class ; rdfs:label "positive regulation of response to extracellular stimulus" ; rdfs:subClassOf obo:GO_0032103, obo:GO_0032104, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009991 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009991 ] ) ] . obo:GO_0032107 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a response to nutrient levels." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032107" ; a owl:Class ; rdfs:label "regulation of response to nutrient levels" ; rdfs:subClassOf obo:GO_0032104, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031667 ] ) ] . obo:GO_0032108 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." ; oboInOwl:hasExactSynonym "down regulation of response to nutrient levels", "down-regulation of response to nutrient levels", "downregulation of response to nutrient levels" ; oboInOwl:hasNarrowSynonym "inhibition of response to nutrient levels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032108" ; a owl:Class ; rdfs:label "negative regulation of response to nutrient levels" ; rdfs:subClassOf obo:GO_0032105, obo:GO_0032107, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031667 ] ) ] . obo:GO_0032109 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." ; oboInOwl:hasExactSynonym "up regulation of response to nutrient levels", "up-regulation of response to nutrient levels", "upregulation of response to nutrient levels" ; oboInOwl:hasNarrowSynonym "activation of response to nutrient levels", "stimulation of response to nutrient levels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032109" ; a owl:Class ; rdfs:label "positive regulation of response to nutrient levels" ; rdfs:subClassOf obo:GO_0032106, obo:GO_0032107, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031667 ] ) ] . obo:GO_0032222 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032222" ; a owl:Class ; rdfs:label "regulation of synaptic transmission, cholinergic" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007271 ] ) ] . obo:GO_0032223 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." ; oboInOwl:hasExactSynonym "down regulation of synaptic transmission, cholinergic", "down-regulation of synaptic transmission, cholinergic", "downregulation of synaptic transmission, cholinergic" ; oboInOwl:hasNarrowSynonym "inhibition of synaptic transmission, cholinergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032223" ; a owl:Class ; rdfs:label "negative regulation of synaptic transmission, cholinergic" ; rdfs:subClassOf obo:GO_0032222, obo:GO_0050805, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007271 ] ) ] . obo:GO_0032224 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." ; oboInOwl:hasExactSynonym "up regulation of synaptic transmission, cholinergic", "up-regulation of synaptic transmission, cholinergic", "upregulation of synaptic transmission, cholinergic" ; oboInOwl:hasNarrowSynonym "activation of synaptic transmission, cholinergic", "stimulation of synaptic transmission, cholinergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032224" ; a owl:Class ; rdfs:label "positive regulation of synaptic transmission, cholinergic" ; rdfs:subClassOf obo:GO_0032222, obo:GO_0050806, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007271 ] ) ] . obo:GO_0032228 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032228" ; a owl:Class ; rdfs:label "regulation of synaptic transmission, GABAergic" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051932 ] ) ] . obo:GO_0032229 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." ; oboInOwl:hasExactSynonym "down regulation of synaptic transmission, GABAergic", "down-regulation of synaptic transmission, GABAergic", "downregulation of synaptic transmission, GABAergic" ; oboInOwl:hasNarrowSynonym "inhibition of synaptic transmission, GABAergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032229" ; a owl:Class ; rdfs:label "negative regulation of synaptic transmission, GABAergic" ; rdfs:subClassOf obo:GO_0032228, obo:GO_0050805, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051932 ] ) ] . obo:GO_0032230 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." ; oboInOwl:hasExactSynonym "up regulation of synaptic transmission, GABAergic", "up-regulation of synaptic transmission, GABAergic", "upregulation of synaptic transmission, GABAergic" ; oboInOwl:hasNarrowSynonym "activation of synaptic transmission, GABAergic", "stimulation of synaptic transmission, GABAergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032230" ; a owl:Class ; rdfs:label "positive regulation of synaptic transmission, GABAergic" ; rdfs:subClassOf obo:GO_0032228, obo:GO_0050806, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051932 ] ) ] . obo:GO_0032274 obo:IAO_0000115 "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." ; oboInOwl:hasExactSynonym "gonadotrophin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032274" ; a owl:Class ; rdfs:label "gonadotropin secretion" ; rdfs:subClassOf obo:GO_0060986 . obo:GO_0032275 obo:IAO_0000115 "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032275" ; a owl:Class ; rdfs:label "luteinizing hormone secretion" ; rdfs:subClassOf obo:GO_0032274 . obo:GO_0032276 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." ; oboInOwl:hasExactSynonym "regulation of gonadotrophin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032276" ; a owl:Class ; rdfs:label "regulation of gonadotropin secretion" ; rdfs:subClassOf obo:GO_0044060, obo:GO_0046883, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032274 ] ) ] . obo:GO_0032277 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." ; oboInOwl:hasExactSynonym "down regulation of gonadotropin secretion", "down-regulation of gonadotropin secretion", "downregulation of gonadotropin secretion", "negative regulation of gonadotrophin secretion" ; oboInOwl:hasNarrowSynonym "inhibition of gonadotropin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032277" ; a owl:Class ; rdfs:label "negative regulation of gonadotropin secretion" ; rdfs:subClassOf obo:GO_0032276, obo:GO_0046888, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032274 ] ) ] . obo:GO_0032278 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." ; oboInOwl:hasExactSynonym "positive regulation of gonadotrophin secretion", "up regulation of gonadotropin secretion", "up-regulation of gonadotropin secretion", "upregulation of gonadotropin secretion" ; oboInOwl:hasNarrowSynonym "activation of gonadotropin secretion", "stimulation of gonadotropin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032278" ; a owl:Class ; rdfs:label "positive regulation of gonadotropin secretion" ; rdfs:subClassOf obo:GO_0032276, obo:GO_0046887, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032274 ] ) ] . obo:GO_0032286 obo:IAO_0000115 "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." ; oboInOwl:hasExactSynonym "central nervous system myelin sheath maintenance", "myelin maintenance in central nervous system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032286" ; a owl:Class ; rdfs:label "central nervous system myelin maintenance" ; rdfs:subClassOf obo:GO_0043217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0022010 ] . obo:GO_0032288 obo:IAO_0000115 "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." ; oboInOwl:hasExactSynonym "myelin sheath assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "myelin formation" ; oboInOwl:id "GO:0032288" ; a owl:Class ; rdfs:label "myelin assembly" ; rdfs:subClassOf obo:GO_0010927, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042552 ] . obo:GO_0032289 obo:IAO_0000115 "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." ; oboInOwl:hasExactSynonym "central nervous system myelin sheath formation", "myelin formation in central nervous system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032289" ; a owl:Class ; rdfs:label "central nervous system myelin formation" ; rdfs:subClassOf obo:GO_0032288, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0022010 ] . obo:GO_0032291 obo:IAO_0000115 "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." ; oboInOwl:hasExactSynonym "ensheathment of axons in central nervous system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032291" ; a owl:Class ; rdfs:label "axon ensheathment in central nervous system" ; rdfs:subClassOf obo:GO_0008366 . obo:GO_0032292 obo:IAO_0000115 "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." ; oboInOwl:hasExactSynonym "ensheathment of axons in peripheral nervous system" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032292" ; a owl:Class ; rdfs:label "peripheral nervous system axon ensheathment" ; rdfs:subClassOf obo:GO_0008366 . obo:GO_0032350 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." ; oboInOwl:hasExactSynonym "regulation of hormone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032350" ; a owl:Class ; rdfs:label "regulation of hormone metabolic process" ; rdfs:subClassOf obo:GO_0010817, obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042445 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042445 ] ) ] . obo:GO_0032351 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." ; oboInOwl:hasExactSynonym "down regulation of hormone metabolic process", "down-regulation of hormone metabolic process", "downregulation of hormone metabolic process", "negative regulation of hormone metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of hormone metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032351" ; a owl:Class ; rdfs:label "negative regulation of hormone metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0032350, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042445 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042445 ] ) ] . obo:GO_0032352 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." ; oboInOwl:hasExactSynonym "positive regulation of hormone metabolism", "up regulation of hormone metabolic process", "up-regulation of hormone metabolic process", "upregulation of hormone metabolic process" ; oboInOwl:hasNarrowSynonym "activation of hormone metabolic process", "stimulation of hormone metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032352" ; a owl:Class ; rdfs:label "positive regulation of hormone metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0032350, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042445 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042445 ] ) ] . obo:GO_0032353 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." ; oboInOwl:hasExactSynonym "down regulation of hormone biosynthetic process", "down-regulation of hormone biosynthetic process", "downregulation of hormone biosynthetic process" ; oboInOwl:hasNarrowSynonym "inhibition of hormone biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032353" ; a owl:Class ; rdfs:label "negative regulation of hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0031327, obo:GO_0032351, obo:GO_0046885, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042446 ] ) ] . obo:GO_0032368 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032368" ; a owl:Class ; rdfs:label "regulation of lipid transport" ; rdfs:subClassOf obo:GO_0051049, obo:GO_1905952, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006869 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006869 ] ) ] . obo:GO_0032369 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of lipid transport", "down-regulation of lipid transport", "downregulation of lipid transport" ; oboInOwl:hasNarrowSynonym "inhibition of lipid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032369" ; a owl:Class ; rdfs:label "negative regulation of lipid transport" ; rdfs:subClassOf obo:GO_0032368, obo:GO_0051051, obo:GO_1905953, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006869 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006869 ] ) ] . obo:GO_0032370 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of lipid transport", "up-regulation of lipid transport", "upregulation of lipid transport" ; oboInOwl:hasNarrowSynonym "activation of lipid transport", "stimulation of lipid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032370" ; a owl:Class ; rdfs:label "positive regulation of lipid transport" ; rdfs:subClassOf obo:GO_0032368, obo:GO_0051050, obo:GO_1905954, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006869 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006869 ] ) ] . obo:GO_0032386 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032386" ; a owl:Class ; rdfs:label "regulation of intracellular transport" ; rdfs:subClassOf obo:GO_0051049, obo:GO_0060341, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046907 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046907 ] ) ] . obo:GO_0032387 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." ; oboInOwl:hasExactSynonym "down regulation of intracellular transport", "down-regulation of intracellular transport", "downregulation of intracellular transport" ; oboInOwl:hasNarrowSynonym "inhibition of intracellular transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032387" ; a owl:Class ; rdfs:label "negative regulation of intracellular transport" ; rdfs:subClassOf obo:GO_0032386, obo:GO_0048523, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046907 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046907 ] ) ] . obo:GO_0032388 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." ; oboInOwl:hasExactSynonym "up regulation of intracellular transport", "up-regulation of intracellular transport", "upregulation of intracellular transport" ; oboInOwl:hasNarrowSynonym "activation of intracellular transport", "stimulation of intracellular transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032388" ; a owl:Class ; rdfs:label "positive regulation of intracellular transport" ; rdfs:subClassOf obo:GO_0032386, obo:GO_0048522, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046907 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046907 ] ) ] . obo:GO_0032409 obo:IAO_0000115 "Any process that modulates the activity of a transporter." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032409" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of transporter activity" ; rdfs:subClassOf obo:GO_0065009, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005215 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005215 ] ) ] . obo:GO_0032410 obo:IAO_0000115 "Any process that stops or reduces the activity of a transporter." ; oboInOwl:hasExactSynonym "down regulation of transporter activity", "down-regulation of transporter activity", "downregulation of transporter activity" ; oboInOwl:hasNarrowSynonym "inhibition of transporter activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032410" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of transporter activity" ; rdfs:subClassOf obo:GO_0032409, obo:GO_0044092, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005215 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005215 ] ) ] . obo:GO_0032411 obo:IAO_0000115 "Any process that activates or increases the activity of a transporter." ; oboInOwl:hasExactSynonym "up regulation of transporter activity", "up-regulation of transporter activity", "upregulation of transporter activity" ; oboInOwl:hasNarrowSynonym "activation of transporter activity", "stimulation of transporter activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032411" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of transporter activity" ; rdfs:subClassOf obo:GO_0032409, obo:GO_0044093, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005215 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005215 ] ) ] . obo:GO_0032432 obo:IAO_0000115 "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." ; oboInOwl:hasAlternativeId "GO:0000141", "GO:0030482" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "actin cable" ; oboInOwl:id "GO:0032432" ; a owl:Class ; rdfs:label "actin filament bundle" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0015629 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005884 ] . obo:GO_0032501 obo:IAO_0000115 "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." ; obo:RO_0002161 obo:NCBITaxon_2, obo:NCBITaxon_2157, obo:NCBITaxon_4932 ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T16:07:47Z" ; oboInOwl:hasAlternativeId "GO:0044707", "GO:0050874" ; oboInOwl:hasExactSynonym "organismal physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-multicellular organism process" ; oboInOwl:id "GO:0032501" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir ; a owl:Class ; rdfs:label "multicellular organismal process" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0032502 obo:IAO_0000115 "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-12-19T12:21:31Z" ; oboInOwl:hasAlternativeId "GO:0044767" ; oboInOwl:hasNarrowSynonym "development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism developmental process" ; oboInOwl:id "GO:0032502" ; oboInOwl:inSubset go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_pir ; a owl:Class ; rdfs:label "developmental process" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0032504 obo:IAO_0000115 "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032504" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "multicellular organism reproduction" ; rdfs:subClassOf obo:GO_0000003, obo:GO_0032501 . obo:GO_0032543 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." ; oboInOwl:hasExactSynonym "mitochondrial protein anabolism", "mitochondrial protein biosynthesis", "mitochondrial protein formation", "mitochondrial protein synthesis", "mitochondrial protein translation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032543" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "mitochondrial translation" ; rdfs:subClassOf obo:GO_0006412, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140053 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140053 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0032594 obo:IAO_0000115 "The directed movement of a protein from one location to another within a lipid bilayer." ; oboInOwl:hasExactSynonym "protein translocation within membrane" ; oboInOwl:hasNarrowSynonym "receptor translocation within membrane", "receptor transport within lipid bilayer" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032594" ; a owl:Class ; rdfs:label "protein transport within lipid bilayer" ; rdfs:subClassOf obo:GO_0006886, obo:GO_0061024, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0016020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0015031 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0016020 ] ) ] . obo:GO_0032602 obo:IAO_0000115 "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." ; oboInOwl:creation_date "2009-12-18T11:26:20Z" ; oboInOwl:hasAlternativeId "GO:0042033", "GO:0050755", "GO:0090195" ; oboInOwl:hasExactSynonym "chemokine anabolism", "chemokine biosynthesis", "chemokine formation", "chemokine synthesis" ; oboInOwl:hasNarrowSynonym "chemokine biosynthetic process", "chemokine metabolic process", "chemokine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032602" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "chemokine production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032609 obo:IAO_0000115 "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." ; oboInOwl:hasAlternativeId "GO:0042095", "GO:0072643" ; oboInOwl:hasExactSynonym "IFNG production", "interferon-gamma production", "type II IFN production" ; oboInOwl:hasNarrowSynonym "interferon-gamma biosynthetic process", "interferon-gamma secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032609" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "type II interferon production" ; rdfs:subClassOf obo:GO_0001816 . obo:GO_0032642 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of chemokine production." ; oboInOwl:creation_date "2009-12-18T11:28:00Z" ; oboInOwl:hasAlternativeId "GO:0045073", "GO:0090196" ; oboInOwl:hasNarrowSynonym "regulation of chemokine biosynthetic process", "regulation of chemokine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032642" ; a owl:Class ; rdfs:label "regulation of chemokine production" ; rdfs:subClassOf obo:GO_0001817, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032602 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032602 ] ) ] . obo:GO_0032649 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." ; oboInOwl:hasAlternativeId "GO:0045072", "GO:1902713" ; oboInOwl:hasExactSynonym "regulation of interferon-gamma production" ; oboInOwl:hasNarrowSynonym "regulation of interferon-gamma biosynthetic process", "regulation of interferon-gamma secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032649" ; a owl:Class ; rdfs:label "regulation of type II interferon production" ; rdfs:subClassOf obo:GO_0001817, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:GO_0032682 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." ; oboInOwl:creation_date "2009-12-18T11:28:00Z" ; oboInOwl:hasAlternativeId "GO:0045079", "GO:0090198" ; oboInOwl:hasExactSynonym "down regulation of chemokine production", "down-regulation of chemokine production", "downregulation of chemokine production" ; oboInOwl:hasNarrowSynonym "inhibition of chemokine production", "negative regulation of chemokine biosynthetic process", "negative regulation of chemokine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032682" ; a owl:Class ; rdfs:label "negative regulation of chemokine production" ; rdfs:subClassOf obo:GO_0001818, obo:GO_0032642, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032602 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032602 ] ) ] . obo:GO_0032689 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." ; oboInOwl:hasAlternativeId "GO:0045077", "GO:1902714" ; oboInOwl:hasExactSynonym "down regulation of interferon-gamma production", "down-regulation of interferon-gamma production", "downregulation of interferon-gamma production", "negative regulation of interferon-gamma production" ; oboInOwl:hasNarrowSynonym "inhibition of interferon-gamma production", "negative regulation of interferon-gamma biosynthetic process", "negative regulation of interferon-gamma secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032689" ; a owl:Class ; rdfs:label "negative regulation of type II interferon production" ; rdfs:subClassOf obo:GO_0001818, obo:GO_0032649, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:GO_0032722 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of chemokine production." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-18T11:28:00Z" ; oboInOwl:hasAlternativeId "GO:0045080", "GO:0090197" ; oboInOwl:hasExactSynonym "up regulation of chemokine production", "up-regulation of chemokine production", "upregulation of chemokine production" ; oboInOwl:hasNarrowSynonym "activation of chemokine production", "positive regulation of chemokine biosynthetic process", "positive regulation of chemokine secretion", "stimulation of chemokine production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032722" ; a owl:Class ; rdfs:label "positive regulation of chemokine production" ; rdfs:subClassOf obo:GO_0001819, obo:GO_0032642, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032602 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032602 ] ) ] . obo:GO_0032729 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." ; oboInOwl:hasAlternativeId "GO:0045078", "GO:1902715" ; oboInOwl:hasExactSynonym "positive regulation of interferon-gamma production", "up regulation of interferon-gamma production", "up-regulation of interferon-gamma production", "upregulation of interferon-gamma production" ; oboInOwl:hasNarrowSynonym "activation of interferon-gamma production", "positive regulation of interferon-gamma biosynthetic process", "positive regulation of interferon-gamma secretion", "stimulation of interferon-gamma production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032729" ; a owl:Class ; rdfs:label "positive regulation of type II interferon production" ; rdfs:subClassOf obo:GO_0001819, obo:GO_0032649, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032609 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032609 ] ) ] . obo:GO_0032782 obo:IAO_0000115 "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032782" ; a owl:Class ; rdfs:label "bile acid secretion" ; rdfs:subClassOf obo:GO_0015718, obo:GO_0046717 . obo:GO_0032787 obo:IAO_0000115 "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." ; oboInOwl:hasExactSynonym "monocarboxylate metabolic process", "monocarboxylic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032787" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "monocarboxylic acid metabolic process" ; rdfs:subClassOf obo:GO_0019752 . obo:GO_0032811 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." ; oboInOwl:hasExactSynonym "down regulation of epinephrine secretion", "down-regulation of epinephrine secretion", "downregulation of epinephrine secretion", "negative regulation of adrenaline secretion" ; oboInOwl:hasNarrowSynonym "inhibition of epinephrine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032811" ; a owl:Class ; rdfs:label "negative regulation of epinephrine secretion" ; rdfs:subClassOf obo:GO_0014060, obo:GO_0033604, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:GO_0032812 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." ; oboInOwl:hasExactSynonym "positive regulation of adrenaline secretion", "up regulation of epinephrine secretion", "up-regulation of epinephrine secretion", "upregulation of epinephrine secretion" ; oboInOwl:hasNarrowSynonym "activation of epinephrine secretion", "stimulation of epinephrine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032812" ; a owl:Class ; rdfs:label "positive regulation of epinephrine secretion" ; rdfs:subClassOf obo:GO_0014060, obo:GO_0033605, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048242 ] ) ] . obo:GO_0032838 obo:IAO_0000115 "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032838" ; a owl:Class ; rdfs:label "plasma membrane bounded cell projection cytoplasm" ; rdfs:subClassOf obo:GO_0099568, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0120025 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0120025 ] ) ] . obo:GO_0032839 obo:IAO_0000115 "All of the contents of a dendrite, excluding the surrounding plasma membrane." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14472"^^xsd:anyURI ; oboInOwl:hasExactSynonym "dendritic cytoplasm" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032839" ; a owl:Class ; rdfs:label "dendrite cytoplasm" ; rdfs:subClassOf obo:GO_0120111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030425 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030425 ] ) ] . obo:GO_0032879 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." ; oboInOwl:hasExactSynonym "regulation of localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032879" ; a owl:Class ; rdfs:label "regulation of localization" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051179 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051179 ] ) ] . obo:GO_0032880 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2015-01-20T14:32:14Z" ; oboInOwl:hasAlternativeId "GO:1903827" ; oboInOwl:hasExactSynonym "regulation of cellular protein localisation", "regulation of cellular protein localization", "regulation of protein localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032880" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "regulation of protein localization" ; rdfs:subClassOf obo:GO_0060341, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008104 ] ) ] . obo:GO_0032881 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032881" ; a owl:Class ; rdfs:label "regulation of polysaccharide metabolic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005976 ] ) ] . obo:GO_0032885 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032885" ; a owl:Class ; rdfs:label "regulation of polysaccharide biosynthetic process" ; rdfs:subClassOf obo:GO_0010556, obo:GO_0032881, obo:GO_0043255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000271 ] ) ] . obo:GO_0032886 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032886" ; a owl:Class ; rdfs:label "regulation of microtubule-based process" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007017 ] ) ] . obo:GO_0032890 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032890" ; a owl:Class ; rdfs:label "regulation of organic acid transport" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015849 ] ) ] . obo:GO_0032891 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of organic acid transport", "down-regulation of organic acid transport", "downregulation of organic acid transport" ; oboInOwl:hasNarrowSynonym "inhibition of organic acid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032891" ; a owl:Class ; rdfs:label "negative regulation of organic acid transport" ; rdfs:subClassOf obo:GO_0032890, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015849 ] ) ] . obo:GO_0032892 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of organic acid transport", "up-regulation of organic acid transport", "upregulation of organic acid transport" ; oboInOwl:hasNarrowSynonym "activation of organic acid transport", "stimulation of organic acid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032892" ; a owl:Class ; rdfs:label "positive regulation of organic acid transport" ; rdfs:subClassOf obo:GO_0032890, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015849 ] ) ] . obo:GO_0032940 obo:IAO_0000115 "The controlled release of a substance by a cell." ; oboInOwl:hasDbXref "Wikipedia:Secretion" ; oboInOwl:hasExactSynonym "cellular secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032940" ; a owl:Class ; rdfs:label "secretion by cell" ; rdfs:subClassOf obo:GO_0046903, obo:GO_0140352 . obo:GO_0032941 obo:IAO_0000115 "The controlled release of a substance by a tissue." ; oboInOwl:hasExactSynonym "tissue secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "expulsion of gland contents" ; oboInOwl:id "GO:0032941" ; a owl:Class ; rdfs:label "secretion by tissue" ; rdfs:subClassOf obo:GO_0032501, obo:GO_0046903 . obo:GO_0032943 obo:IAO_0000115 "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." ; oboInOwl:hasNarrowSynonym "PBMC proliferation", "peripheral blood mononuclear cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032943" ; a owl:Class ; rdfs:label "mononuclear cell proliferation" ; rdfs:subClassOf obo:GO_0070661 . obo:GO_0032944 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." ; oboInOwl:hasNarrowSynonym "regulation of PBMC proliferation", "regulation of peripheral blood mononuclear cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032944" ; a owl:Class ; rdfs:label "regulation of mononuclear cell proliferation" ; rdfs:subClassOf obo:GO_0070663, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032943 ] ) ] . obo:GO_0032945 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." ; oboInOwl:hasNarrowSynonym "negative regulation of PBMC proliferation", "negative regulation of peripheral blood mononuclear cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032945" ; a owl:Class ; rdfs:label "negative regulation of mononuclear cell proliferation" ; rdfs:subClassOf obo:GO_0032944, obo:GO_0070664, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032943 ] ) ] . obo:GO_0032946 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." ; oboInOwl:hasExactSynonym "up regulation of mononuclear cell proliferation", "up-regulation of mononuclear cell proliferation", "upregulation of mononuclear cell proliferation" ; oboInOwl:hasNarrowSynonym "activation of mononuclear cell proliferation", "positive regulation of PBMC proliferation", "positive regulation of peripheral blood mononuclear cell proliferation", "stimulation of mononuclear cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032946" ; a owl:Class ; rdfs:label "positive regulation of mononuclear cell proliferation" ; rdfs:subClassOf obo:GO_0032944, obo:GO_0070665, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032943 ] ) ] . obo:GO_0032989 obo:IAO_0000115 "The process in which cellular structures, including whole cells or cell parts, are generated and organized." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/25496"^^xsd:anyURI ; oboInOwl:hasExactSynonym "cellular structure morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0032989" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular component morphogenesis" ; rdfs:subClassOf obo:GO_0009653 . obo:GO_0032991 obo:IAO_0000115 "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ; oboInOwl:hasAlternativeId "GO:0043234" ; oboInOwl:hasExactSynonym "macromolecular complex", "macromolecule complex", "protein containing complex" ; oboInOwl:hasNarrowSynonym "protein complex", "protein-protein complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032991" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir ; a owl:Class ; rdfs:comment "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole." ; rdfs:label "protein-containing complex" ; rdfs:subClassOf obo:GO_0005575 . obo:GO_0032993 obo:IAO_0000115 "A macromolecular complex containing both protein and DNA molecules." ; oboInOwl:hasExactSynonym "DNA-protein complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032993" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:comment "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here." ; rdfs:label "protein-DNA complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0032994 obo:IAO_0000115 "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032994" ; a owl:Class ; rdfs:comment "Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes." ; rdfs:label "protein-lipid complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0032997 obo:IAO_0000115 "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." ; oboInOwl:hasBroadSynonym "immunoglobulin receptor complex" ; oboInOwl:hasExactSynonym "Fc-receptor complex", "FcR complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0032997" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "Fc receptor complex" ; rdfs:subClassOf obo:GO_0098797 . obo:GO_0033001 obo:IAO_0000115 "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." ; oboInOwl:hasBroadSynonym "IgG receptor complex", "immunoglobulin G receptor complex" ; oboInOwl:hasExactSynonym "FcgRIII complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0033001" ; a owl:Class ; rdfs:label "Fc-gamma receptor III complex" ; rdfs:subClassOf obo:GO_0032997 . obo:GO_0033013 obo:IAO_0000115 "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." ; oboInOwl:hasExactSynonym "tetrapyrrole metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033013" ; oboInOwl:inSubset go:goslim_pombe, go:prokaryote_subset ; a owl:Class ; rdfs:label "tetrapyrrole metabolic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_0046483, obo:GO_1901360, obo:GO_1901564 . obo:GO_0033014 obo:IAO_0000115 "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." ; oboInOwl:hasExactSynonym "tetrapyrrole anabolism", "tetrapyrrole biosynthesis", "tetrapyrrole formation", "tetrapyrrole synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033014" ; a owl:Class ; rdfs:label "tetrapyrrole biosynthetic process" ; rdfs:subClassOf obo:GO_0018130, obo:GO_0019438, obo:GO_0033013, obo:GO_0044271, obo:GO_1901362, obo:GO_1901566 . obo:GO_0033036 obo:IAO_0000115 "Any process in which a macromolecule is transported to, or maintained in, a specific location." ; oboInOwl:hasExactSynonym "macromolecule localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033036" ; oboInOwl:inSubset go:goslim_flybase_ribbon ; a owl:Class ; rdfs:label "macromolecule localization" ; rdfs:subClassOf obo:GO_0051179 . obo:GO_0033043 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." ; oboInOwl:hasExactSynonym "regulation of organelle organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of organelle organization and biogenesis" ; oboInOwl:id "GO:0033043" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of organelle organization" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006996 ] ) ] . obo:GO_0033044 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." ; oboInOwl:hasExactSynonym "regulation of chromosome organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of chromosome organization and biogenesis" ; oboInOwl:id "GO:0033044" ; a owl:Class ; rdfs:label "regulation of chromosome organization" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051276 ] ) ] . obo:GO_0033045 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sister chromatid segregation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033045" ; a owl:Class ; rdfs:label "regulation of sister chromatid segregation" ; rdfs:subClassOf obo:GO_0033044, obo:GO_0051983, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000819 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000819 ] ) ] . obo:GO_0033046 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033046" ; a owl:Class ; rdfs:label "negative regulation of sister chromatid segregation" ; rdfs:subClassOf obo:GO_0033045, obo:GO_0051985, obo:GO_2001251, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000819 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000819 ] ) ] . obo:GO_0033047 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033047" ; a owl:Class ; rdfs:label "regulation of mitotic sister chromatid segregation" ; rdfs:subClassOf obo:GO_0033045, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000070 ] ) ] . obo:GO_0033048 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033048" ; a owl:Class ; rdfs:label "negative regulation of mitotic sister chromatid segregation" ; rdfs:subClassOf obo:GO_0033046, obo:GO_0033047, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000070 ] ) ] . obo:GO_0033151 obo:IAO_0000115 "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." ; oboInOwl:hasDbXref "Wikipedia:V(D)J_recombination" ; oboInOwl:hasExactSynonym "V(D)J joining", "V-D-J joining", "V-D-J recombination", "V-J joining", "V-J recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033151" ; a owl:Class ; rdfs:label "V(D)J recombination" ; rdfs:subClassOf obo:GO_0002562 . obo:GO_0033152 obo:IAO_0000115 "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." ; oboInOwl:hasExactSynonym "immunoglobulin V(D)J joining" ; oboInOwl:hasNarrowSynonym "immunoglobulin V-D-J joining", "immunoglobulin V-D-J recombination", "immunoglobulin V-J joining", "immunoglobulin V-J recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033152" ; a owl:Class ; rdfs:label "immunoglobulin V(D)J recombination" ; rdfs:subClassOf obo:GO_0016447, obo:GO_0033151 . obo:GO_0033157 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033157" ; a owl:Class ; rdfs:label "regulation of intracellular protein transport" ; rdfs:subClassOf obo:GO_0032386, obo:GO_0051223, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006886 ] ) ] . obo:GO_0033238 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." ; oboInOwl:hasExactSynonym "regulation of amine metabolism", "regulation of cellular amine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033238" ; a owl:Class ; rdfs:label "regulation of amine metabolic process" ; rdfs:subClassOf obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009308 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009308 ] ) ] . obo:GO_0033239 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." ; oboInOwl:hasExactSynonym "negative regulation of amine metabolism", "negative regulation of cellular amine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033239" ; a owl:Class ; rdfs:label "negative regulation of amine metabolic process" ; rdfs:subClassOf obo:GO_0033238, obo:GO_0051172, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009308 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009308 ] ) ] . obo:GO_0033240 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." ; oboInOwl:hasExactSynonym "positive regulation of amine metabolism", "positive regulation of cellular amine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033240" ; a owl:Class ; rdfs:label "positive regulation of amine metabolic process" ; rdfs:subClassOf obo:GO_0033238, obo:GO_0051173, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009308 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009308 ] ) ] . obo:GO_0033363 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." ; oboInOwl:hasExactSynonym "secretory granule organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "secretory granule organization and biogenesis" ; oboInOwl:id "GO:0033363" ; a owl:Class ; rdfs:label "secretory granule organization" ; rdfs:subClassOf obo:GO_0016050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010256 ] . obo:GO_0033365 obo:IAO_0000115 "A process in which a protein is transported to, or maintained in, a location within an organelle." ; oboInOwl:hasExactSynonym "protein localisation to organelle", "protein localization in organelle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033365" ; a owl:Class ; rdfs:label "protein localization to organelle" ; rdfs:subClassOf obo:GO_0008104 . obo:GO_0033500 obo:IAO_0000115 "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033500" ; a owl:Class ; rdfs:label "carbohydrate homeostasis" ; rdfs:subClassOf obo:GO_0048878 . obo:GO_0033554 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033554" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "cellular response to stress" ; rdfs:subClassOf obo:GO_0006950, obo:GO_0051716 . obo:GO_0033559 obo:IAO_0000115 "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." ; oboInOwl:hasDbXref "MetaCyc:PWY-762", "MetaCyc:PWY-782" ; oboInOwl:hasExactSynonym "unsaturated fatty acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033559" ; a owl:Class ; rdfs:label "unsaturated fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0006631 . obo:GO_0033602 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." ; oboInOwl:hasExactSynonym "down regulation of dopamine secretion", "down-regulation of dopamine secretion", "downregulation of dopamine secretion" ; oboInOwl:hasNarrowSynonym "inhibition of dopamine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033602" ; a owl:Class ; rdfs:label "negative regulation of dopamine secretion" ; rdfs:subClassOf obo:GO_0014059, obo:GO_0033604, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014046 ] ) ] . obo:GO_0033603 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." ; oboInOwl:hasExactSynonym "up regulation of dopamine secretion", "up-regulation of dopamine secretion", "upregulation of dopamine secretion" ; oboInOwl:hasNarrowSynonym "activation of dopamine secretion", "stimulation of dopamine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033603" ; a owl:Class ; rdfs:label "positive regulation of dopamine secretion" ; rdfs:subClassOf obo:GO_0014059, obo:GO_0033605, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014046 ] ) ] . obo:GO_0033604 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." ; oboInOwl:hasExactSynonym "down regulation of catecholamine secretion", "down-regulation of catecholamine secretion", "downregulation of catecholamine secretion" ; oboInOwl:hasNarrowSynonym "inhibition of catecholamine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033604" ; a owl:Class ; rdfs:label "negative regulation of catecholamine secretion" ; rdfs:subClassOf obo:GO_0050433, obo:GO_0051953, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050432 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050432 ] ) ] . obo:GO_0033605 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." ; oboInOwl:hasExactSynonym "up regulation of catecholamine secretion", "up-regulation of catecholamine secretion", "upregulation of catecholamine secretion" ; oboInOwl:hasNarrowSynonym "activation of catecholamine secretion", "stimulation of catecholamine secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033605" ; a owl:Class ; rdfs:label "positive regulation of catecholamine secretion" ; rdfs:subClassOf obo:GO_0050433, obo:GO_0051954, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050432 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050432 ] ) ] . obo:GO_0033673 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ; oboInOwl:hasExactSynonym "down regulation of kinase activity", "down-regulation of kinase activity", "downregulation of kinase activity" ; oboInOwl:hasNarrowSynonym "inhibition of kinase activity", "kinase inhibitor" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033673" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of kinase activity" ; rdfs:subClassOf obo:GO_0042326, obo:GO_0043549, obo:GO_0051348, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016301 ] ) ] . obo:GO_0033674 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ; oboInOwl:hasExactSynonym "up regulation of kinase activity", "up-regulation of kinase activity", "upregulation of kinase activity" ; oboInOwl:hasNarrowSynonym "kinase activator", "stimulation of kinase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033674" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of kinase activity" ; rdfs:subClassOf obo:GO_0042327, obo:GO_0043549, obo:GO_0051347, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016301 ] ) ] . obo:GO_0033684 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033684" ; a owl:Class ; rdfs:label "regulation of luteinizing hormone secretion" ; rdfs:subClassOf obo:GO_0032276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032275 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032275 ] ) ] . obo:GO_0033685 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." ; oboInOwl:hasExactSynonym "down regulation of luteinizing hormone secretion", "down-regulation of luteinizing hormone secretion", "downregulation of luteinizing hormone secretion" ; oboInOwl:hasNarrowSynonym "inhibition of luteinizing hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033685" ; a owl:Class ; rdfs:label "negative regulation of luteinizing hormone secretion" ; rdfs:subClassOf obo:GO_0032277, obo:GO_0033684, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032275 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032275 ] ) ] . obo:GO_0033686 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." ; oboInOwl:hasExactSynonym "up regulation of luteinizing hormone secretion", "up-regulation of luteinizing hormone secretion", "upregulation of luteinizing hormone secretion" ; oboInOwl:hasNarrowSynonym "activation of luteinizing hormone secretion", "stimulation of luteinizing hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0033686" ; a owl:Class ; rdfs:label "positive regulation of luteinizing hormone secretion" ; rdfs:subClassOf obo:GO_0032278, obo:GO_0033684, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032275 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032275 ] ) ] . obo:GO_0034097 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." ; oboInOwl:hasExactSynonym "response to cytokine stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034097" ; a owl:Class ; rdfs:label "response to cytokine" ; rdfs:subClassOf obo:GO_0010033 . obo:GO_0034101 obo:IAO_0000115 "Any process of regulating the production and elimination of erythrocytes within an organism." ; oboInOwl:hasExactSynonym "RBC homeostasis", "red blood cell homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034101" ; a owl:Class ; rdfs:label "erythrocyte homeostasis" ; rdfs:subClassOf obo:GO_0002262 . obo:GO_0034103 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of tissue remodeling." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034103" ; a owl:Class ; rdfs:label "regulation of tissue remodeling" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048771 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048771 ] ) ] . obo:GO_0034104 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034104" ; a owl:Class ; rdfs:label "negative regulation of tissue remodeling" ; rdfs:subClassOf obo:GO_0034103, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048771 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048771 ] ) ] . obo:GO_0034105 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034105" ; a owl:Class ; rdfs:label "positive regulation of tissue remodeling" ; rdfs:subClassOf obo:GO_0034103, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048771 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048771 ] ) ] . obo:GO_0034109 obo:IAO_0000115 "The attachment of a cell to a second cell of the identical type via adhesion molecules." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034109" ; a owl:Class ; rdfs:comment "Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms." ; rdfs:label "homotypic cell-cell adhesion" ; rdfs:subClassOf obo:GO_0098609 . obo:GO_0034110 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034110" ; a owl:Class ; rdfs:label "regulation of homotypic cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022407, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034109 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034109 ] ) ] . obo:GO_0034111 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034111" ; a owl:Class ; rdfs:label "negative regulation of homotypic cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022408, obo:GO_0034110, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034109 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034109 ] ) ] . obo:GO_0034112 obo:IAO_0000115 "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034112" ; a owl:Class ; rdfs:label "positive regulation of homotypic cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022409, obo:GO_0034110, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034109 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034109 ] ) ] . obo:GO_0034219 obo:IAO_0000115 "The process in which a carbohydrate is transported across a membrane." ; oboInOwl:hasExactSynonym "carbohydrate membrane transport", "transmembrane carbohydrate transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034219" ; a owl:Class ; rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes." ; rdfs:label "carbohydrate transmembrane transport" ; rdfs:subClassOf obo:GO_0008643, obo:GO_0055085 . obo:GO_0034220 obo:IAO_0000115 "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." ; oboInOwl:hasAlternativeId "GO:0099131" ; oboInOwl:hasBroadSynonym "ion transmembrane transport" ; oboInOwl:hasExactSynonym "ion membrane transport", "transmembrane ion transport" ; oboInOwl:hasNarrowSynonym "ATP hydrolysis coupled ion transmembrane transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034220" ; a owl:Class ; rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes." ; rdfs:label "monoatomic ion transmembrane transport" ; rdfs:subClassOf obo:GO_0006811, obo:GO_0055085 . obo:GO_0034248 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." ; oboInOwl:hasExactSynonym "regulation of amide metabolism", "regulation of cellular amide metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034248" ; a owl:Class ; rdfs:label "regulation of amide metabolic process" ; rdfs:subClassOf obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043603 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043603 ] ) ] . obo:GO_0034249 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." ; oboInOwl:hasExactSynonym "negative regulation of amide metabolism", "negative regulation of cellular amide metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034249" ; a owl:Class ; rdfs:label "negative regulation of amide metabolic process" ; rdfs:subClassOf obo:GO_0034248, obo:GO_0051172, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043603 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043603 ] ) ] . obo:GO_0034250 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." ; oboInOwl:hasExactSynonym "positive regulation of amide metabolism", "positive regulation of cellular amide metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034250" ; a owl:Class ; rdfs:label "positive regulation of amide metabolic process" ; rdfs:subClassOf obo:GO_0034248, obo:GO_0051173, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043603 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043603 ] ) ] . obo:GO_0034358 obo:IAO_0000115 "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0034358" ; a owl:Class ; rdfs:label "plasma lipoprotein particle" ; rdfs:subClassOf obo:GO_1990777, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005615 ] . obo:GO_0034435 obo:IAO_0000115 "OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19255"^^xsd:anyURI ; oboInOwl:consider "GO:0008203" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034435" ; a owl:Class ; rdfs:comment "This term was obsoleted because it represents a molecular function." ; rdfs:label "obsolete cholesterol esterification" ; owl:deprecated true . obo:GO_0034505 obo:IAO_0000115 "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." ; oboInOwl:hasExactSynonym "tooth calcification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034505" ; a owl:Class ; rdfs:label "tooth mineralization" ; rdfs:subClassOf obo:GO_0031214, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042476 ] . obo:GO_0034641 obo:IAO_0000115 "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." ; oboInOwl:hasExactSynonym "cellular nitrogen compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034641" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "cellular nitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0006807, obo:GO_0044237 . obo:GO_0034762 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." ; oboInOwl:hasExactSynonym "regulation of membrane transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034762" ; a owl:Class ; rdfs:label "regulation of transmembrane transport" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0055085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0055085 ] ) ] . obo:GO_0034763 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." ; oboInOwl:hasExactSynonym "down regulation of transmembrane transport", "down-regulation of transmembrane transport", "downregulation of transmembrane transport", "negative regulation of membrane transport" ; oboInOwl:hasNarrowSynonym "inhibition of transmembrane transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034763" ; a owl:Class ; rdfs:label "negative regulation of transmembrane transport" ; rdfs:subClassOf obo:GO_0034762, obo:GO_0048523, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0055085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0055085 ] ) ] . obo:GO_0034764 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." ; oboInOwl:hasExactSynonym "positive regulation of membrane transport", "up regulation of transmembrane transport", "up-regulation of transmembrane transport", "upregulation of transmembrane transport" ; oboInOwl:hasNarrowSynonym "activation of transmembrane transport", "stimulation of transmembrane transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034764" ; a owl:Class ; rdfs:label "positive regulation of transmembrane transport" ; rdfs:subClassOf obo:GO_0034762, obo:GO_0048522, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0055085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0055085 ] ) ] . obo:GO_0034765 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." ; oboInOwl:hasBroadSynonym "regulation of ion transmembrane transport" ; oboInOwl:hasExactSynonym "regulation of ion membrane transport", "regulation of transmembrane ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034765" ; a owl:Class ; rdfs:label "regulation of monoatomic ion transmembrane transport" ; rdfs:subClassOf obo:GO_0034762, obo:GO_0043269, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034220 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034220 ] ) ] . obo:GO_0034766 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." ; oboInOwl:hasBroadSynonym "negative regulation of ion transmembrane transport" ; oboInOwl:hasExactSynonym "down regulation of transmembrane ion transport", "down-regulation of transmembrane ion transport", "downregulation of transmembrane ion transport", "negative regulation of ion membrane transport", "negative regulation of transmembrane ion transport" ; oboInOwl:hasNarrowSynonym "inhibition of transmembrane ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034766" ; a owl:Class ; rdfs:label "negative regulation of monoatomic ion transmembrane transport" ; rdfs:subClassOf obo:GO_0034763, obo:GO_0034765, obo:GO_0043271, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034220 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034220 ] ) ] . obo:GO_0034767 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." ; oboInOwl:hasBroadSynonym "positive regulation of ion transmembrane transport" ; oboInOwl:hasExactSynonym "positive regulation of ion membrane transport", "positive regulation of transmembrane ion transport", "up regulation of transmembrane ion transport", "up-regulation of transmembrane ion transport", "upregulation of transmembrane ion transport" ; oboInOwl:hasNarrowSynonym "activation of transmembrane ion transport", "stimulation of transmembrane ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0034767" ; a owl:Class ; rdfs:label "positive regulation of monoatomic ion transmembrane transport" ; rdfs:subClassOf obo:GO_0034764, obo:GO_0034765, obo:GO_0043270, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034220 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034220 ] ) ] . obo:GO_0034982 obo:IAO_0000115 "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mitochondrial protein modification" ; oboInOwl:id "GO:0034982" ; a owl:Class ; rdfs:label "mitochondrial protein processing" ; rdfs:subClassOf obo:GO_0016485, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0035082 obo:IAO_0000115 "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." ; oboInOwl:hasAlternativeId "GO:0035083", "GO:0035084" ; oboInOwl:hasExactSynonym "ciliary axoneme assembly", "cilium axoneme assembly", "flagellar axoneme assembly", "flagellum axoneme assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "axoneme biogenesis", "cilium axoneme biogenesis" ; oboInOwl:id "GO:0035082" ; a owl:Class ; rdfs:comment "Note that cilia and eukaryotic flagella are deemed to be equivalent." ; rdfs:label "axoneme assembly" ; rdfs:subClassOf obo:GO_0001578, obo:GO_0022607, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060271 ] . obo:GO_0035148 obo:IAO_0000115 "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." ; oboInOwl:hasExactSynonym "tube lumen formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "lumen formation in an anatomical structure" ; oboInOwl:id "GO:0035148" ; a owl:Class ; rdfs:label "tube formation" ; rdfs:subClassOf obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0035239 ] . obo:GO_0035176 obo:IAO_0000115 "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." ; oboInOwl:hasDbXref "Wikipedia:Social_behavior" ; oboInOwl:hasExactSynonym "social behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cooperative behavior" ; oboInOwl:id "GO:0035176" ; a owl:Class ; rdfs:comment "Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior." ; rdfs:label "social behavior" ; rdfs:subClassOf obo:GO_0007610, obo:GO_0051703 . obo:GO_0035239 obo:IAO_0000115 "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035239" ; a owl:Class ; rdfs:label "tube morphogenesis" ; rdfs:subClassOf obo:GO_0009653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0035295 ] . obo:GO_0035249 obo:IAO_0000115 "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." ; oboInOwl:hasExactSynonym "glutamatergic synaptic transmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035249" ; a owl:Class ; rdfs:label "synaptic transmission, glutamatergic" ; rdfs:subClassOf obo:GO_0007268 . obo:GO_0035265 obo:IAO_0000115 "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035265" ; a owl:Class ; rdfs:label "organ growth" ; rdfs:subClassOf obo:GO_0032501, obo:GO_0048589 . obo:GO_0035282 obo:IAO_0000115 "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." ; oboInOwl:hasDbXref "Wikipedia:Segmentation_(biology)" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035282" ; a owl:Class ; rdfs:label "segmentation" ; rdfs:subClassOf obo:GO_0003002 . obo:GO_0035295 obo:IAO_0000115 "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035295" ; a owl:Class ; rdfs:label "tube development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0035303 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035303" ; a owl:Class ; rdfs:label "regulation of dephosphorylation" ; rdfs:subClassOf obo:GO_0019220, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016311 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016311 ] ) ] . obo:GO_0035305 obo:IAO_0000115 "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." ; oboInOwl:hasExactSynonym "down regulation of dephosphorylation", "down-regulation of dephosphorylation", "downregulation of dephosphorylation" ; oboInOwl:hasNarrowSynonym "inhibition of dephosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035305" ; a owl:Class ; rdfs:label "negative regulation of dephosphorylation" ; rdfs:subClassOf obo:GO_0035303, obo:GO_0045936, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016311 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016311 ] ) ] . obo:GO_0035306 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." ; oboInOwl:hasExactSynonym "up regulation of dephosphorylation", "up-regulation of dephosphorylation", "upregulation of dephosphorylation" ; oboInOwl:hasNarrowSynonym "activation of dephosphorylation", "stimulation of dephosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035306" ; a owl:Class ; rdfs:label "positive regulation of dephosphorylation" ; rdfs:subClassOf obo:GO_0035303, obo:GO_0045937, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016311 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016311 ] ) ] . obo:GO_0035369 obo:IAO_0000115 "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-03-11T10:46:10Z" ; oboInOwl:hasExactSynonym "pre-BCR" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0035369" ; a owl:Class ; rdfs:comment "Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome." ; rdfs:label "pre-B cell receptor complex" ; rdfs:subClassOf obo:GO_0098796 . obo:GO_0035556 obo:IAO_0000115 "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-05-14T01:14:37Z" ; oboInOwl:hasAlternativeId "GO:0007242", "GO:0007243", "GO:0023013", "GO:0023034" ; oboInOwl:hasExactSynonym "intracellular signaling chain" ; oboInOwl:hasNarrowSynonym "intracellular protein kinase cascade", "intracellular signal transduction pathway", "protein kinase cascade", "signal transmission via intracellular cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intracellular signaling cascade", "intracellular signaling pathway", "signal transduction via intracellular signaling cascade" ; oboInOwl:id "GO:0035556" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "intracellular signal transduction" ; rdfs:subClassOf obo:GO_0007165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0035592 obo:IAO_0000115 "The directed movement of a protein to a specific location within the extracellular region." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-11-09T10:25:08Z" ; oboInOwl:hasExactSynonym "establishment of protein localisation in extracellular region", "establishment of protein localization in extracellular region" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035592" ; a owl:Class ; rdfs:label "establishment of protein localization to extracellular region" ; rdfs:subClassOf obo:GO_0045184, obo:GO_0071692 . obo:GO_0035630 obo:IAO_0000115 "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-20T01:57:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035630" ; a owl:Class ; rdfs:comment "Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'." ; rdfs:label "bone mineralization involved in bone maturation" ; rdfs:subClassOf obo:GO_0030282, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030282 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043931 ] ) ] . obo:GO_0035735 obo:IAO_0000115 "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-03-17T10:55:42Z" ; oboInOwl:hasBroadSynonym "intraflagellar transport" ; oboInOwl:hasDbXref "Reactome:R-HSA-5620924.2" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intraciliary transport involved in cilium morphogenesis", "intraflagellar transport involved in cilium morphogenesis" ; oboInOwl:id "GO:0035735" ; a owl:Class ; rdfs:label "intraciliary transport involved in cilium assembly" ; rdfs:subClassOf obo:GO_0042073, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042073 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060271 ] ) ] . obo:GO_0035809 obo:IAO_0000115 "Any process that modulates the amount of urine excreted from the body over a unit of time." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-04-20T01:17:38Z" ; oboInOwl:hasExactSynonym "regulation of urinary volume", "regulation of urine flow" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035809" ; a owl:Class ; rdfs:label "regulation of urine volume" ; rdfs:subClassOf obo:GO_0003014, obo:GO_0050878 . obo:GO_0035821 obo:IAO_0000115 "The process in which an organism effects a change in the structure or processes of another organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/18605"^^xsd:anyURI ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-04-21T01:31:51Z" ; oboInOwl:hasExactSynonym "modification of morphology or physiology of other organism", "modulation of process of other organism" ; oboInOwl:hasNarrowSynonym "regulation of morphology of other organism", "regulation of physiological process of other organism", "regulation of physiology of other organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of morphology or physiology of other organism" ; oboInOwl:id "GO:0035821" ; a owl:Class ; rdfs:label "modulation of process of another organism" ; rdfs:subClassOf obo:GO_0044419 . obo:GO_0035878 obo:IAO_0000115 "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-05-31T02:30:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035878" ; a owl:Class ; rdfs:label "nail development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060173 ] . obo:GO_0035898 obo:IAO_0000115 "The regulated release of parathyroid hormone into the circulatory system." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-06-22T09:28:54Z" ; oboInOwl:hasExactSynonym "PTH secretion", "parathormone secretion", "parathyrin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035898" ; a owl:Class ; rdfs:label "parathyroid hormone secretion" ; rdfs:subClassOf obo:GO_0060986 . obo:GO_0035929 obo:IAO_0000115 "The regulated release of any steroid that acts as a hormone into the circulatory system." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:01:00Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035929" ; a owl:Class ; rdfs:label "steroid hormone secretion" ; rdfs:subClassOf obo:GO_0060986, obo:GO_0140353 . obo:GO_0035930 obo:IAO_0000115 "The regulated release of any corticosteroid hormone into the circulatory system." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:03:22Z" ; oboInOwl:hasBroadSynonym "corticosteroid secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035930" ; a owl:Class ; rdfs:label "corticosteroid hormone secretion" ; rdfs:subClassOf obo:GO_0035929 . obo:GO_0035931 obo:IAO_0000115 "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:04:59Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035931" ; a owl:Class ; rdfs:label "mineralocorticoid secretion" ; rdfs:subClassOf obo:GO_0035930 . obo:GO_0035932 obo:IAO_0000115 "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:06:24Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035932" ; a owl:Class ; rdfs:label "aldosterone secretion" ; rdfs:subClassOf obo:GO_0015850, obo:GO_0035931 . obo:GO_0035935 obo:IAO_0000115 "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:11:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035935" ; a owl:Class ; rdfs:label "androgen secretion" ; rdfs:subClassOf obo:GO_0035929 . obo:GO_0035936 obo:IAO_0000115 "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-20T01:13:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0035936" ; a owl:Class ; rdfs:label "testosterone secretion" ; rdfs:subClassOf obo:GO_0015850, obo:GO_0046879, obo:GO_0140353 . obo:GO_0036065 obo:IAO_0000115 "The covalent attachment of a fucosyl group to an acceptor molecule." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-12-15T11:16:19Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036065" ; a owl:Class ; rdfs:label "fucosylation" ; rdfs:subClassOf obo:GO_0070085 . obo:GO_0036066 obo:IAO_0000115 "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-12-15T11:17:20Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036066" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "protein O-linked fucosylation" ; rdfs:subClassOf obo:GO_0006493, obo:GO_0036065 . obo:GO_0036072 obo:IAO_0000115 "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-12-19T01:47:22Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036072" ; a owl:Class ; rdfs:label "direct ossification" ; rdfs:subClassOf obo:GO_0001503 . obo:GO_0036075 obo:IAO_0000115 "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-12-19T01:53:16Z" ; oboInOwl:hasExactSynonym "indirect ossification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036075" ; a owl:Class ; rdfs:label "replacement ossification" ; rdfs:subClassOf obo:GO_0001503 . obo:GO_0036160 obo:IAO_0000115 "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-03-26T01:16:55Z" ; oboInOwl:hasExactSynonym "MSH secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036160" ; a owl:Class ; rdfs:label "melanocyte-stimulating hormone secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0036161 obo:IAO_0000115 "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-03-26T01:30:32Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036161" ; a owl:Class ; rdfs:label "calcitonin secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0036194 obo:IAO_0000115 "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-04-20T10:20:47Z" ; oboInOwl:hasExactSynonym "myocyte projection" ; oboInOwl:hasNarrowSynonym "muscle arm", "myopodia" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0036194" ; a owl:Class ; rdfs:label "muscle cell projection" ; rdfs:subClassOf obo:GO_0120025 . obo:GO_0036211 obo:IAO_0000115 "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-04-26T01:47:12Z" ; oboInOwl:hasAlternativeId "GO:0006464" ; oboInOwl:hasExactSynonym "cellular protein modification process", "process resulting in protein modification", "protein modification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0036211" ; oboInOwl:inSubset go:goslim_candida, go:goslim_chembl, go:goslim_pir, go:goslim_plant, go:prokaryote_subset ; a owl:Class ; rdfs:label "protein modification process" ; rdfs:subClassOf obo:GO_0019538, obo:GO_0043412 . obo:GO_0036477 obo:IAO_0000115 "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2014-07-24T10:06:19Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0036477" ; a owl:Class ; rdfs:label "somatodendritic compartment" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0038023 obo:IAO_0000115 "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-08-01T02:45:27Z" ; oboInOwl:hasAlternativeId "GO:0004872", "GO:0019041" ; oboInOwl:hasBroadSynonym "receptor activity" ; oboInOwl:hasExactSynonym "receptor activity involved in signal transduction", "signalling receptor activity" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0038023" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_metagenomics, go:goslim_mouse, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "signaling receptor activity" ; rdfs:subClassOf obo:GO_0060089 . obo:GO_0040007 obo:IAO_0000115 "The increase in size or mass of an entire organism, a part of an organism or a cell." ; oboInOwl:hasAlternativeId "GO:0048590" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "growth pattern", "non-developmental growth" ; oboInOwl:id "GO:0040007" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_chembl, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:comment "See also the biological process term 'cell growth ; GO:0016049'." ; rdfs:label "growth" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0040008 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040008" ; a owl:Class ; rdfs:label "regulation of growth" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0040007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0040007 ] ) ] . obo:GO_0040011 obo:IAO_0000115 "Self-propelled movement of a cell or organism from one location to another." ; obo:RO_0002161 obo:NCBITaxon_451864 ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040011" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir ; a owl:Class ; rdfs:label "locomotion" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0044848 . obo:GO_0040012 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040012" ; a owl:Class ; rdfs:label "regulation of locomotion" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0040011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0040011 ] ) ] . obo:GO_0040013 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." ; oboInOwl:hasExactSynonym "down regulation of locomotion", "down-regulation of locomotion", "downregulation of locomotion" ; oboInOwl:hasNarrowSynonym "inhibition of locomotion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040013" ; a owl:Class ; rdfs:label "negative regulation of locomotion" ; rdfs:subClassOf obo:GO_0040012, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0040011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0040011 ] ) ] . obo:GO_0040016 obo:IAO_0000115 "The first few specialized divisions of an activated animal egg." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040016" ; a owl:Class ; rdfs:label "embryonic cleavage" ; rdfs:subClassOf obo:GO_0051301, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009790 ] . obo:GO_0040017 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." ; oboInOwl:hasExactSynonym "up regulation of locomotion", "up-regulation of locomotion", "upregulation of locomotion" ; oboInOwl:hasNarrowSynonym "activation of locomotion", "stimulation of locomotion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040017" ; a owl:Class ; rdfs:label "positive regulation of locomotion" ; rdfs:subClassOf obo:GO_0040012, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0040011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0040011 ] ) ] . obo:GO_0040019 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of embryonic development." ; oboInOwl:hasExactSynonym "up regulation of embryonic development", "up-regulation of embryonic development", "upregulation of embryonic development" ; oboInOwl:hasNarrowSynonym "activation of embryonic development", "stimulation of embryonic development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040019" ; a owl:Class ; rdfs:label "positive regulation of embryonic development" ; rdfs:subClassOf obo:GO_0045995, obo:GO_0051094, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009790 ] ) ] . obo:GO_0040020 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." ; oboInOwl:hasBroadSynonym "regulation of meiosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040020" ; a owl:Class ; rdfs:label "regulation of meiotic nuclear division" ; rdfs:subClassOf obo:GO_0010564, obo:GO_0051445, obo:GO_0051783, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140013 ] ) ] . obo:GO_0040029 obo:IAO_0000115 "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22201"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/24794"^^xsd:anyURI ; oboInOwl:hasExactSynonym "regulation of gene expression, epigenetic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0040029" ; oboInOwl:inSubset go:goslim_plant ; a owl:Class ; rdfs:label "epigenetic regulation of gene expression" ; rdfs:subClassOf obo:GO_0006338, obo:GO_0010468 . obo:GO_0042044 obo:IAO_0000115 "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042044" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "fluid transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0042060 obo:IAO_0000115 "The series of events that restore integrity to a damaged tissue, following an injury." ; oboInOwl:hasDbXref "Wikipedia:Wound_healing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042060" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "wound healing" ; rdfs:subClassOf obo:GO_0009611, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0042246 ] . obo:GO_0042063 obo:IAO_0000115 "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." ; oboInOwl:hasExactSynonym "glial cell generation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042063" ; a owl:Class ; rdfs:label "gliogenesis" ; rdfs:subClassOf obo:GO_0022008 . obo:GO_0042065 obo:IAO_0000115 "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042065" ; a owl:Class ; rdfs:label "glial cell growth" ; rdfs:subClassOf obo:GO_0048588, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042063 ] . obo:GO_0042073 obo:IAO_0000115 "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." ; obo:RO_0002161 obo:NCBITaxon_3176, obo:NCBITaxon_3312, obo:NCBITaxon_3378, obo:NCBITaxon_3398, obo:NCBITaxon_4890, obo:NCBITaxon_5782 ; oboInOwl:hasAlternativeId "GO:0035734" ; oboInOwl:hasDbXref "Wikipedia:Intraflagellar_transport" ; oboInOwl:hasExactSynonym "intraflagellar transport", "intraflagellar transport involved in cilium organization", "intraflagellar transport involved in microtubule-based flagellum organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "IFT" ; oboInOwl:id "GO:0042073" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "intraciliary transport" ; rdfs:subClassOf obo:GO_0010970, obo:GO_0031503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0044782 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005929 ] . obo:GO_0042074 obo:IAO_0000115 "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042074" ; a owl:Class ; rdfs:label "cell migration involved in gastrulation" ; rdfs:subClassOf obo:GO_0001667, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016477 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007369 ] ) ] . obo:GO_0042092 obo:IAO_0000115 "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." ; oboInOwl:hasNarrowSynonym "T-helper 2 type immune response", "Th2 immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042092" ; a owl:Class ; rdfs:label "type 2 immune response" ; rdfs:subClassOf obo:GO_0006955 . obo:GO_0042098 obo:IAO_0000115 "The expansion of a T cell population by cell division. Follows T cell activation." ; oboInOwl:hasAlternativeId "GO:0042111" ; oboInOwl:hasExactSynonym "T lymphocyte proliferation", "T-cell proliferation", "T-lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042098" ; a owl:Class ; rdfs:label "T cell proliferation" ; rdfs:subClassOf obo:GO_0042110, obo:GO_0046651 . obo:GO_0042100 obo:IAO_0000115 "The expansion of a B cell population by cell division. Follows B cell activation." ; oboInOwl:hasAlternativeId "GO:0042114" ; oboInOwl:hasExactSynonym "B lymphocyte proliferation", "B-cell proliferation", "B-lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042100" ; a owl:Class ; rdfs:label "B cell proliferation" ; rdfs:subClassOf obo:GO_0042113, obo:GO_0046651 . obo:GO_0042101 obo:IAO_0000115 "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." ; oboInOwl:hasDbXref "Wikipedia:T_cell_receptor" ; oboInOwl:hasExactSynonym "T lymphocyte receptor complex", "T-cell receptor complex", "T-lymphocyte receptor complex", "TCR complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "TCR" ; oboInOwl:id "GO:0042101" ; a owl:Class ; rdfs:label "T cell receptor complex" ; rdfs:subClassOf obo:GO_0098802 . obo:GO_0042102 obo:IAO_0000115 "Any process that activates or increases the rate or extent of T cell proliferation." ; oboInOwl:hasExactSynonym "positive regulation of T lymphocyte proliferation", "positive regulation of T-lymphocyte proliferation", "up regulation of T cell proliferation", "up-regulation of T cell proliferation", "upregulation of T cell proliferation" ; oboInOwl:hasNarrowSynonym "activation of T cell proliferation", "stimulation of T cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042102" ; a owl:Class ; rdfs:label "positive regulation of T cell proliferation" ; rdfs:subClassOf obo:GO_0042129, obo:GO_0050671, obo:GO_0050870, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042098 ] ) ] . obo:GO_0042105 obo:IAO_0000115 "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." ; oboInOwl:hasExactSynonym "alpha-beta T lymphocyte receptor complex", "alpha-beta T-cell receptor complex", "alpha-beta T-lymphocyte receptor complex", "alpha-beta TCR complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042105" ; a owl:Class ; rdfs:label "alpha-beta T cell receptor complex" ; rdfs:subClassOf obo:GO_0042101 . obo:GO_0042106 obo:IAO_0000115 "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." ; oboInOwl:hasExactSynonym "gamma-delta T lymphocyte receptor complex", "gamma-delta T-cell receptor complex", "gamma-delta T-lymphocyte receptor complex", "gamma-delta TCR complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042106" ; a owl:Class ; rdfs:label "gamma-delta T cell receptor complex" ; rdfs:subClassOf obo:GO_0042101 . obo:GO_0042110 obo:IAO_0000115 "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; oboInOwl:hasExactSynonym "T lymphocyte activation", "T-cell activation", "T-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042110" ; a owl:Class ; rdfs:label "T cell activation" ; rdfs:subClassOf obo:GO_0046649 . obo:GO_0042113 obo:IAO_0000115 "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; oboInOwl:hasExactSynonym "B lymphocyte activation", "B-cell activation", "B-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042113" ; a owl:Class ; rdfs:label "B cell activation" ; rdfs:subClassOf obo:GO_0046649 . obo:GO_0042127 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell proliferation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cell proliferation" ; oboInOwl:id "GO:0042127" ; a owl:Class ; rdfs:label "regulation of cell population proliferation" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008283 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008283 ] ) ] . obo:GO_0042129 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of T cell proliferation." ; oboInOwl:hasExactSynonym "regulation of T lymphocyte proliferation", "regulation of T-cell proliferation", "regulation of T-lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042129" ; a owl:Class ; rdfs:label "regulation of T cell proliferation" ; rdfs:subClassOf obo:GO_0050670, obo:GO_0050863, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042098 ] ) ] . obo:GO_0042130 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." ; oboInOwl:hasExactSynonym "down regulation of T cell proliferation", "down-regulation of T cell proliferation", "downregulation of T cell proliferation", "negative regulation of T lymphocyte proliferation", "negative regulation of T-cell proliferation", "negative regulation of T-lymphocyte proliferation" ; oboInOwl:hasNarrowSynonym "inhibition of T cell proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042130" ; a owl:Class ; rdfs:label "negative regulation of T cell proliferation" ; rdfs:subClassOf obo:GO_0042129, obo:GO_0050672, obo:GO_0050868, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042098 ] ) ] . obo:GO_0042168 obo:IAO_0000115 "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." ; oboInOwl:hasExactSynonym "haem metabolic process", "haem metabolism", "heme metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042168" ; a owl:Class ; rdfs:label "heme metabolic process" ; rdfs:subClassOf obo:GO_0006778, obo:GO_0042440 . obo:GO_0042180 obo:IAO_0000115 "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." ; oboInOwl:hasExactSynonym "ketone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042180" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular ketone metabolic process" ; rdfs:subClassOf obo:GO_0044237, obo:GO_0044281, obo:GO_0071704 . obo:GO_0042182 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." ; oboInOwl:hasExactSynonym "ketone breakdown", "ketone catabolism", "ketone degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042182" ; a owl:Class ; rdfs:label "ketone catabolic process" ; rdfs:subClassOf obo:GO_0042180, obo:GO_0044248, obo:GO_0044282, obo:GO_1901575 . obo:GO_0042221 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." ; oboInOwl:hasExactSynonym "response to chemical stimulus", "response to chemical substance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042221" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_candida, go:goslim_drosophila, go:goslim_metagenomics, go:goslim_plant, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to chemical" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0042246 obo:IAO_0000115 "The regrowth of lost or destroyed tissues." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042246" ; a owl:Class ; rdfs:label "tissue regeneration" ; rdfs:subClassOf obo:GO_0031099, obo:GO_0048589 . obo:GO_0042320 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." ; oboInOwl:hasExactSynonym "regulation of REM sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042320" ; a owl:Class ; rdfs:label "regulation of circadian sleep/wake cycle, REM sleep" ; rdfs:subClassOf obo:GO_0045187, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042747 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042747 ] ) ] . obo:GO_0042321 obo:IAO_0000115 "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." ; oboInOwl:hasExactSynonym "down regulation of circadian sleep/wake cycle, sleep", "down-regulation of circadian sleep/wake cycle, sleep", "downregulation of circadian sleep/wake cycle, sleep", "negative regulation of sleep" ; oboInOwl:hasNarrowSynonym "inhibition of circadian sleep/wake cycle, sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042321" ; a owl:Class ; rdfs:label "negative regulation of circadian sleep/wake cycle, sleep" ; rdfs:subClassOf obo:GO_0042754, obo:GO_0045187, obo:GO_0048521, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050802 ] ) ] . obo:GO_0042322 obo:IAO_0000115 "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." ; oboInOwl:hasExactSynonym "down regulation of circadian sleep/wake cycle, REM sleep", "down-regulation of circadian sleep/wake cycle, REM sleep", "downregulation of circadian sleep/wake cycle, REM sleep", "negative regulation of REM sleep" ; oboInOwl:hasNarrowSynonym "inhibition of circadian sleep/wake cycle, REM sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042322" ; a owl:Class ; rdfs:label "negative regulation of circadian sleep/wake cycle, REM sleep" ; rdfs:subClassOf obo:GO_0042320, obo:GO_0042321, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042747 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042747 ] ) ] . obo:GO_0042325 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042325" ; a owl:Class ; rdfs:label "regulation of phosphorylation" ; rdfs:subClassOf obo:GO_0019220, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016310 ] ) ] . obo:GO_0042326 obo:IAO_0000115 "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." ; oboInOwl:hasExactSynonym "down regulation of phosphorylation", "down-regulation of phosphorylation", "downregulation of phosphorylation" ; oboInOwl:hasNarrowSynonym "inhibition of phosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042326" ; a owl:Class ; rdfs:label "negative regulation of phosphorylation" ; rdfs:subClassOf obo:GO_0042325, obo:GO_0045936, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016310 ] ) ] . obo:GO_0042327 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." ; oboInOwl:hasExactSynonym "up regulation of phosphorylation", "up-regulation of phosphorylation", "upregulation of phosphorylation" ; oboInOwl:hasNarrowSynonym "activation of phosphorylation", "stimulation of phosphorylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042327" ; a owl:Class ; rdfs:label "positive regulation of phosphorylation" ; rdfs:subClassOf obo:GO_0042325, obo:GO_0045937, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016310 ] ) ] . obo:GO_0042330 obo:IAO_0000115 "The directed movement of a motile cell or organism in response to an external stimulus." ; oboInOwl:hasDbXref "Wikipedia:Taxis" ; oboInOwl:hasExactSynonym "directed movement in response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042330" ; a owl:Class ; rdfs:label "taxis" ; rdfs:subClassOf obo:GO_0040011, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009605 ] . obo:GO_0042359 obo:IAO_0000115 "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." ; oboInOwl:hasExactSynonym "vitamin D metabolism" ; oboInOwl:hasNarrowSynonym "calciferol metabolic process", "calciferol metabolism", "cholecalciferol metabolic process", "cholecalciferol metabolism", "ergocalciferol metabolic process", "ergocalciferol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042359" ; a owl:Class ; rdfs:label "vitamin D metabolic process" ; rdfs:subClassOf obo:GO_0006775, obo:GO_0008202, obo:GO_1901615 . obo:GO_0042360 obo:IAO_0000115 "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." ; oboInOwl:hasExactSynonym "tocopherol metabolic process", "tocopherol metabolism", "vitamin E metabolism" ; oboInOwl:hasNarrowSynonym "alpha-tocopherol metabolic process", "alpha-tocopherol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042360" ; a owl:Class ; rdfs:label "vitamin E metabolic process" ; rdfs:subClassOf obo:GO_0006775, obo:GO_0046483, obo:GO_1901360, obo:GO_1901615 . obo:GO_0042373 obo:IAO_0000115 "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." ; oboInOwl:hasBroadSynonym "naphthoquinone metabolic process", "naphthoquinone metabolism" ; oboInOwl:hasExactSynonym "vitamin K metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042373" ; a owl:Class ; rdfs:label "vitamin K metabolic process" ; rdfs:subClassOf obo:GO_0006775, obo:GO_1901661 . obo:GO_0042391 obo:IAO_0000115 "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042391" ; a owl:Class ; rdfs:label "regulation of membrane potential" ; rdfs:subClassOf obo:GO_0065008, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0034220 ] . obo:GO_0042403 obo:IAO_0000115 "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." ; oboInOwl:hasExactSynonym "thyroid hormone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042403" ; a owl:Class ; rdfs:label "thyroid hormone metabolic process" ; rdfs:subClassOf obo:GO_0006575, obo:GO_0018958, obo:GO_0042445 . obo:GO_0042405 obo:IAO_0000115 "An intranuclear focus at which aggregated proteins have been sequestered." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042405" ; a owl:Class ; rdfs:label "nuclear inclusion body" ; rdfs:subClassOf obo:GO_0016234, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016234 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ) ] . obo:GO_0042430 obo:IAO_0000115 "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." ; oboInOwl:hasAlternativeId "GO:0042434" ; oboInOwl:hasExactSynonym "indole and derivative metabolic process", "indole and derivative metabolism", "indole-containing compound metabolism", "ketole metabolic process", "ketole metabolism" ; oboInOwl:hasNarrowSynonym "indole derivative metabolic process", "indole derivative metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042430" ; a owl:Class ; rdfs:label "indole-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_0034641, obo:GO_0046483, obo:GO_1901360, obo:GO_1901564 . obo:GO_0042435 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." ; oboInOwl:hasExactSynonym "indole derivative biosynthesis", "indole derivative biosynthetic process", "indole-containing compound anabolism", "indole-containing compound biosynthesis", "indole-containing compound formation", "indole-containing compound synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042435" ; a owl:Class ; rdfs:label "indole-containing compound biosynthetic process" ; rdfs:subClassOf obo:GO_0018130, obo:GO_0019438, obo:GO_0042430, obo:GO_0044271, obo:GO_1901362, obo:GO_1901566 . obo:GO_0042440 obo:IAO_0000115 "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." ; oboInOwl:hasExactSynonym "pigment metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042440" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_pir ; a owl:Class ; rdfs:label "pigment metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0042445 obo:IAO_0000115 "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23965"^^xsd:anyURI ; obo:RO_0002161 obo:NCBITaxon_4895 ; oboInOwl:hasAlternativeId "GO:0034754" ; oboInOwl:hasExactSynonym "hormone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cellular hormone metabolic process" ; oboInOwl:id "GO:0042445" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "hormone metabolic process" ; rdfs:subClassOf obo:GO_0008152, obo:GO_0010817 . obo:GO_0042446 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." ; oboInOwl:hasExactSynonym "hormone anabolism", "hormone biosynthesis", "hormone formation", "hormone synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042446" ; a owl:Class ; rdfs:label "hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0009058, obo:GO_0042445 . obo:GO_0042465 obo:IAO_0000115 "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." ; oboInOwl:hasDbXref "Wikipedia:Kinesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042465" ; a owl:Class ; rdfs:label "kinesis" ; rdfs:subClassOf obo:GO_0009605 . obo:GO_0042470 obo:IAO_0000115 "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." ; obo:RO_0002161 obo:NCBITaxon_4895 ; oboInOwl:hasDbXref "Wikipedia:Melanosome" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042470" ; a owl:Class ; rdfs:label "melanosome" ; rdfs:subClassOf obo:GO_0048770 . obo:GO_0042475 obo:IAO_0000115 "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." ; oboInOwl:hasBroadSynonym "odontogeny", "odontosis", "tooth development" ; oboInOwl:hasExactSynonym "odontogenesis of dentine-containing teeth", "odontogenesis of dentine-containing tooth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042475" ; a owl:Class ; rdfs:comment "Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See Wikipedia:Placoid_scale#Placoid_scales." ; rdfs:label "odontogenesis of dentin-containing tooth" ; rdfs:subClassOf obo:GO_0042476 . obo:GO_0042476 obo:IAO_0000115 "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." ; oboInOwl:hasAlternativeId "GO:0042477" ; oboInOwl:hasDbXref "Wikipedia:Odontogenesis" ; oboInOwl:hasExactSynonym "odontogeny", "odontosis", "tooth morphogenesis" ; oboInOwl:hasNarrowSynonym "odontogenesis of calcareous or chitinous tooth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "tooth development" ; oboInOwl:id "GO:0042476" ; a owl:Class ; rdfs:label "odontogenesis" ; rdfs:subClassOf obo:GO_0009887 . obo:GO_0042481 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." ; oboInOwl:hasAlternativeId "GO:0042484" ; oboInOwl:hasExactSynonym "regulation of tooth development" ; oboInOwl:hasNarrowSynonym "regulation of odontogenesis of calcareous or chitinous tooth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042481" ; a owl:Class ; rdfs:label "regulation of odontogenesis" ; rdfs:subClassOf obo:GO_2000027, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042476 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042476 ] ) ] . obo:GO_0042482 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." ; oboInOwl:hasAlternativeId "GO:0042485" ; oboInOwl:hasExactSynonym "positive regulation of tooth development", "up regulation of odontogenesis", "up-regulation of odontogenesis", "upregulation of odontogenesis" ; oboInOwl:hasNarrowSynonym "activation of odontogenesis", "positive regulation of odontogenesis of calcareous or chitinous tooth", "stimulation of odontogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042482" ; a owl:Class ; rdfs:label "positive regulation of odontogenesis" ; rdfs:subClassOf obo:GO_0042481, obo:GO_0110110, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042476 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042476 ] ) ] . obo:GO_0042483 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." ; oboInOwl:hasAlternativeId "GO:0042486" ; oboInOwl:hasExactSynonym "down regulation of odontogenesis", "down-regulation of odontogenesis", "downregulation of odontogenesis", "negative regulation of tooth development" ; oboInOwl:hasNarrowSynonym "inhibition of odontogenesis", "negative regulation of odontogenesis of calcareous or chitinous tooth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042483" ; a owl:Class ; rdfs:label "negative regulation of odontogenesis" ; rdfs:subClassOf obo:GO_0042481, obo:GO_0110111, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042476 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042476 ] ) ] . obo:GO_0042487 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." ; oboInOwl:hasExactSynonym "regulation of odontogenesis of dentine-containing teeth", "regulation of odontogenesis of dentine-containing tooth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042487" ; a owl:Class ; rdfs:label "regulation of odontogenesis of dentin-containing tooth" ; rdfs:subClassOf obo:GO_0042481, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042475 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042475 ] ) ] . obo:GO_0042488 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." ; oboInOwl:hasBroadSynonym "activation of odontogenesis", "stimulation of odontogenesis", "up regulation of odontogenesis", "up-regulation of odontogenesis", "upregulation of odontogenesis" ; oboInOwl:hasExactSynonym "positive regulation of odontogenesis of dentine-containing teeth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of odontogenesis of dentine-containing tooth" ; oboInOwl:id "GO:0042488" ; a owl:Class ; rdfs:label "positive regulation of odontogenesis of dentin-containing tooth" ; rdfs:subClassOf obo:GO_0042482, obo:GO_0042487, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042475 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042475 ] ) ] . obo:GO_0042489 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." ; oboInOwl:hasBroadSynonym "down regulation of odontogenesis", "down-regulation of odontogenesis", "downregulation of odontogenesis", "inhibition of odontogenesis", "negative regulation of odontogenesis" ; oboInOwl:hasExactSynonym "negative regulation of odontogenesis of dentine-containing teeth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of odontogenesis of dentine-containing tooth" ; oboInOwl:id "GO:0042489" ; a owl:Class ; rdfs:label "negative regulation of odontogenesis of dentin-containing tooth" ; rdfs:subClassOf obo:GO_0042483, obo:GO_0042487, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042475 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042475 ] ) ] . obo:GO_0042492 obo:IAO_0000115 "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." ; oboInOwl:hasExactSynonym "gamma-delta T lymphocyte differentiation", "gamma-delta T-cell differentiation", "gamma-delta T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "gamma-delta T cell development" ; oboInOwl:id "GO:0042492" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "gamma-delta T cell differentiation" ; rdfs:subClassOf obo:GO_0030217, obo:GO_0046629 . obo:GO_0042552 obo:IAO_0000115 "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." ; oboInOwl:hasDbXref "Wikipedia:Myelin" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "myelinogenesis" ; oboInOwl:id "GO:0042552" ; a owl:Class ; rdfs:label "myelination" ; rdfs:subClassOf obo:GO_0008366 . obo:GO_0042571 obo:IAO_0000115 "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." ; oboInOwl:hasDbXref "Wikipedia:Antibody" ; oboInOwl:hasExactSynonym "antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042571" ; a owl:Class ; rdfs:comment "Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0019814, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005615 ] . obo:GO_0042578 obo:IAO_0000115 "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0042578" ; a owl:Class ; rdfs:label "phosphoric ester hydrolase activity" ; rdfs:subClassOf obo:GO_0016788 . obo:GO_0042582 obo:IAO_0000115 "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." ; oboInOwl:hasExactSynonym "primary granule" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042582" ; a owl:Class ; rdfs:label "azurophil granule" ; rdfs:subClassOf obo:GO_0005766, obo:GO_0030141 . obo:GO_0042588 obo:IAO_0000115 "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042588" ; a owl:Class ; rdfs:label "zymogen granule" ; rdfs:subClassOf obo:GO_0030141 . obo:GO_0042589 obo:IAO_0000115 "The lipid bilayer surrounding a zymogen granule." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042589" ; a owl:Class ; rdfs:label "zymogen granule membrane" ; rdfs:subClassOf obo:GO_0030667, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042588 ] . obo:GO_0042592 obo:IAO_0000115 "Any biological process involved in the maintenance of an internal steady state." ; oboInOwl:hasAlternativeId "GO:0032844", "GO:0032845", "GO:0032846" ; oboInOwl:hasExactSynonym "homeostasis" ; oboInOwl:hasNarrowSynonym "activation of homeostatic process", "inhibition of homeostatic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of homeostatic process", "positive regulation of homeostatic process", "regulation of homeostatic process" ; oboInOwl:id "GO:0042592" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_mouse ; a owl:Class ; rdfs:label "homeostatic process" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0042593 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042593" ; a owl:Class ; rdfs:label "glucose homeostasis" ; rdfs:subClassOf obo:GO_0033500 . obo:GO_0042611 obo:IAO_0000115 "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042611" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "MHC protein complex" ; rdfs:subClassOf obo:GO_0098797 . obo:GO_0042613 obo:IAO_0000115 "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042613" ; a owl:Class ; rdfs:label "MHC class II protein complex" ; rdfs:subClassOf obo:GO_0042611 . obo:GO_0042627 obo:IAO_0000115 "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." ; oboInOwl:hasDbXref "Wikipedia:Chylomicron" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042627" ; a owl:Class ; rdfs:label "chylomicron" ; rdfs:subClassOf obo:GO_0034358 . obo:GO_0042645 obo:IAO_0000115 "The region of a mitochondrion to which the DNA is confined." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042645" ; a owl:Class ; rdfs:label "mitochondrial nucleoid" ; rdfs:subClassOf obo:GO_0009295, obo:GO_0043232, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005759 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0042695 obo:IAO_0000115 "The beginning of development of the breasts in the female." ; oboInOwl:hasDbXref "Wikipedia:Thelarche" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042695" ; a owl:Class ; rdfs:label "thelarche" ; rdfs:subClassOf obo:GO_0046543, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030879 ] . obo:GO_0042696 obo:IAO_0000115 "The beginning of the menstrual cycle; the first menstrual cycle in an individual." ; oboInOwl:hasDbXref "Wikipedia:Menarche" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042696" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "menarche" ; rdfs:subClassOf obo:GO_0022601 . obo:GO_0042703 obo:IAO_0000115 "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." ; oboInOwl:hasDbXref "Wikipedia:Menstruation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042703" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "menstruation" ; rdfs:subClassOf obo:GO_0022601 . obo:GO_0042713 obo:IAO_0000115 "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042713" ; a owl:Class ; rdfs:label "sperm ejaculation" ; rdfs:subClassOf obo:GO_0048609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007320 ] . obo:GO_0042730 obo:IAO_0000115 "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." ; oboInOwl:hasDbXref "Wikipedia:Fibrinolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042730" ; a owl:Class ; rdfs:label "fibrinolysis" ; rdfs:subClassOf obo:GO_0030195 . obo:GO_0042742 obo:IAO_0000115 "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." ; oboInOwl:hasAlternativeId "GO:0009816", "GO:0042830" ; oboInOwl:hasExactSynonym "defence response to bacteria", "defence response to bacterium", "defense response to bacteria" ; oboInOwl:hasNarrowSynonym "defense response to bacterium, incompatible interaction", "resistance response to pathogenic bacteria", "resistance response to pathogenic bacterium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "antibacterial peptide activity" ; oboInOwl:id "GO:0042742" ; a owl:Class ; rdfs:label "defense response to bacterium" ; rdfs:subClassOf obo:GO_0009617, obo:GO_0098542 . obo:GO_0042745 obo:IAO_0000115 "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042745" ; a owl:Class ; rdfs:label "circadian sleep/wake cycle" ; rdfs:subClassOf obo:GO_0048512 . obo:GO_0042747 obo:IAO_0000115 "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042747" ; a owl:Class ; rdfs:label "circadian sleep/wake cycle, REM sleep" ; rdfs:subClassOf obo:GO_0022410, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050802 ] . obo:GO_0042749 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042749" ; a owl:Class ; rdfs:label "regulation of circadian sleep/wake cycle" ; rdfs:subClassOf obo:GO_0042752, obo:GO_0050795, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042745 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042745 ] ) ] . obo:GO_0042752 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042752" ; a owl:Class ; rdfs:label "regulation of circadian rhythm" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007623 ] ) ] . obo:GO_0042753 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." ; oboInOwl:hasExactSynonym "up regulation of circadian rhythm", "up-regulation of circadian rhythm", "upregulation of circadian rhythm" ; oboInOwl:hasNarrowSynonym "activation of circadian rhythm", "stimulation of circadian rhythm" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042753" ; a owl:Class ; rdfs:label "positive regulation of circadian rhythm" ; rdfs:subClassOf obo:GO_0042752, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007623 ] ) ] . obo:GO_0042754 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." ; oboInOwl:hasExactSynonym "down regulation of circadian rhythm", "down-regulation of circadian rhythm", "downregulation of circadian rhythm" ; oboInOwl:hasNarrowSynonym "inhibition of circadian rhythm" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042754" ; a owl:Class ; rdfs:label "negative regulation of circadian rhythm" ; rdfs:subClassOf obo:GO_0042752, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007623 ] ) ] . obo:GO_0042755 obo:IAO_0000115 "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." ; oboInOwl:hasExactSynonym "eating behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042755" ; a owl:Class ; rdfs:label "eating behavior" ; rdfs:subClassOf obo:GO_0007631 . obo:GO_0042756 obo:IAO_0000115 "The specific behavior of an organism relating to the intake of liquids, especially water." ; oboInOwl:hasExactSynonym "drinking behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042756" ; a owl:Class ; rdfs:label "drinking behavior" ; rdfs:subClassOf obo:GO_0007631 . obo:GO_0042762 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." ; oboInOwl:hasExactSynonym "regulation of sulfur metabolism", "regulation of sulphur metabolic process", "regulation of sulphur metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042762" ; a owl:Class ; rdfs:label "regulation of sulfur metabolic process" ; rdfs:subClassOf obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006790 ] ) ] . obo:GO_0042886 obo:IAO_0000115 "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0042886" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "amide transport" ; rdfs:subClassOf obo:GO_0071705 . obo:GO_0042981 obo:IAO_0000115 "Any process that modulates the occurrence or rate of cell death by apoptotic process." ; oboInOwl:hasNarrowSynonym "regulation of apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "apoptosis regulator activity" ; oboInOwl:id "GO:0042981" ; a owl:Class ; rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ; rdfs:label "regulation of apoptotic process" ; rdfs:subClassOf obo:GO_0043067, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006915 ] ) ] . obo:GO_0042995 obo:IAO_0000115 "A prolongation or process extending from a cell, e.g. a flagellum or axon." ; oboInOwl:hasBroadSynonym "cell process", "cellular process" ; oboInOwl:hasExactSynonym "cellular projection" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0042995" ; oboInOwl:inSubset go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:label "cell projection" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0043005 obo:IAO_0000115 "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." ; oboInOwl:hasDbXref "NIF_Subcellular:sao867568886" ; oboInOwl:hasExactSynonym "neuron process", "neuron protrusion", "neuronal cell projection" ; oboInOwl:hasNarrowSynonym "neurite" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "nerve fiber" ; oboInOwl:id "GO:0043005" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "neuron projection" ; rdfs:subClassOf obo:GO_0120025 . obo:GO_0043009 obo:IAO_0000115 "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043009" ; a owl:Class ; rdfs:label "chordate embryonic development" ; rdfs:subClassOf obo:GO_0009792 . obo:GO_0043011 obo:IAO_0000115 "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." ; oboInOwl:hasDbXref "Wikipedia:Dendritic_cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043011" ; a owl:Class ; rdfs:label "myeloid dendritic cell differentiation" ; rdfs:subClassOf obo:GO_0001773, obo:GO_0002573, obo:GO_0097028 . obo:GO_0043025 obo:IAO_0000115 "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1044911821", "Wikipedia:Soma_(biology)" ; oboInOwl:hasExactSynonym "neuron cell body", "neuronal cell soma" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043025" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:comment "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ; rdfs:label "neuronal cell body" ; rdfs:subClassOf obo:GO_0044297, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0036477 ] . obo:GO_0043043 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." ; oboInOwl:hasExactSynonym "peptide anabolism", "peptide biosynthesis", "peptide formation", "peptide synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043043" ; a owl:Class ; rdfs:label "peptide biosynthetic process" ; rdfs:subClassOf obo:GO_0006518, obo:GO_0043604, obo:GO_1901566 . obo:GO_0043062 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." ; oboInOwl:hasExactSynonym "extracellular structure organisation", "extracellular structure organization and biogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043062" ; oboInOwl:inSubset go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:label "extracellular structure organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0043065 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." ; oboInOwl:hasExactSynonym "up regulation of apoptosis", "up-regulation of apoptosis", "upregulation of apoptosis" ; oboInOwl:hasNarrowSynonym "activation of apoptosis", "positive regulation of apoptosis", "stimulation of apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pro-apoptosis" ; oboInOwl:id "GO:0043065" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ; rdfs:label "positive regulation of apoptotic process" ; rdfs:subClassOf obo:GO_0042981, obo:GO_0043068, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006915 ] ) ] . obo:GO_0043066 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." ; oboInOwl:hasAlternativeId "GO:0006916" ; oboInOwl:hasExactSynonym "anti-apoptosis", "down regulation of apoptosis", "down-regulation of apoptosis", "downregulation of apoptosis" ; oboInOwl:hasNarrowSynonym "inhibition of apoptosis", "negative regulation of apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "apoptosis inhibitor activity", "pro-survival" ; oboInOwl:id "GO:0043066" ; a owl:Class ; rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ; rdfs:label "negative regulation of apoptotic process" ; rdfs:subClassOf obo:GO_0042981, obo:GO_0043069, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006915 ] ) ] . obo:GO_0043067 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." ; oboInOwl:hasAlternativeId "GO:0043070" ; oboInOwl:hasNarrowSynonym "regulation of non-apoptotic programmed cell death" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043067" ; a owl:Class ; rdfs:label "regulation of programmed cell death" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0012501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0012501 ] ) ] . obo:GO_0043068 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." ; oboInOwl:hasAlternativeId "GO:0043071" ; oboInOwl:hasExactSynonym "up regulation of programmed cell death", "up-regulation of programmed cell death", "upregulation of programmed cell death" ; oboInOwl:hasNarrowSynonym "activation of programmed cell death", "positive regulation of non-apoptotic programmed cell death", "stimulation of programmed cell death" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043068" ; a owl:Class ; rdfs:label "positive regulation of programmed cell death" ; rdfs:subClassOf obo:GO_0043067, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0012501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0012501 ] ) ] . obo:GO_0043069 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." ; oboInOwl:hasAlternativeId "GO:0043072" ; oboInOwl:hasExactSynonym "down regulation of programmed cell death", "down-regulation of programmed cell death", "downregulation of programmed cell death" ; oboInOwl:hasNarrowSynonym "inhibition of programmed cell death", "negative regulation of non-apoptotic programmed cell death" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043069" ; a owl:Class ; rdfs:label "negative regulation of programmed cell death" ; rdfs:subClassOf obo:GO_0043067, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0012501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0012501 ] ) ] . obo:GO_0043084 obo:IAO_0000115 "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." ; oboInOwl:hasDbXref "Wikipedia:Erection#Penile_erection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043084" ; a owl:Class ; rdfs:label "penile erection" ; rdfs:subClassOf obo:GO_0048609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007620 ] . obo:GO_0043085 obo:IAO_0000115 "Any process that activates or increases the activity of an enzyme." ; oboInOwl:hasAlternativeId "GO:0048554" ; oboInOwl:hasExactSynonym "positive regulation of enzyme activity", "up regulation of enzyme activity", "up-regulation of enzyme activity", "upregulation of enzyme activity" ; oboInOwl:hasNarrowSynonym "activation of enzyme activity", "activation of metalloenzyme activity", "positive regulation of metalloenzyme activity", "stimulation of enzyme activity", "stimulation of metalloenzyme activity", "up regulation of metalloenzyme activity", "up-regulation of metalloenzyme activity", "upregulation of metalloenzyme activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043085" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_chembl ; a owl:Class ; rdfs:label "positive regulation of catalytic activity" ; rdfs:subClassOf obo:GO_0044093, obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003824 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003824 ] ) ] . obo:GO_0043086 obo:IAO_0000115 "Any process that stops or reduces the activity of an enzyme." ; oboInOwl:hasAlternativeId "GO:0048553" ; oboInOwl:hasExactSynonym "down regulation of enzyme activity", "down-regulation of enzyme activity", "down-regulation of metalloenzyme activity", "downregulation of enzyme activity", "negative regulation of enzyme activity" ; oboInOwl:hasNarrowSynonym "down regulation of metalloenzyme activity", "downregulation of metalloenzyme activity", "inhibition of enzyme activity", "inhibition of metalloenzyme activity", "negative regulation of metalloenzyme activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043086" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of catalytic activity" ; rdfs:subClassOf obo:GO_0044092, obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003824 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003824 ] ) ] . obo:GO_0043129 obo:IAO_0000115 "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24222"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0050828" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of liquid surface tension", "regulation of surface tension of a liquid", "surfactant activity" ; oboInOwl:id "GO:0043129" ; a owl:Class ; rdfs:label "surfactant homeostasis" ; rdfs:subClassOf obo:GO_0140962 . obo:GO_0043143 obo:IAO_0000115 "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." ; oboInOwl:hasExactSynonym "establishment and maintenance of translational machinery localization", "establishment and maintenance of translational protein localization", "regulation of translation by machinery localisation", "translational machinery localization", "translational protein localization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043143" ; a owl:Class ; rdfs:label "regulation of translation by machinery localization" ; rdfs:subClassOf obo:GO_0006417, obo:GO_0008104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0008104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0043170 obo:IAO_0000115 "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasAlternativeId "GO:0034960", "GO:0043283", "GO:0044259" ; oboInOwl:hasExactSynonym "biopolymer metabolic process", "macromolecule metabolism", "organismal macromolecule metabolism" ; oboInOwl:hasNarrowSynonym "multicellular organismal macromolecule metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043170" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "macromolecule metabolic process" ; rdfs:subClassOf obo:GO_0071704 . obo:GO_0043207 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043207" ; a owl:Class ; rdfs:label "response to external biotic stimulus" ; rdfs:subClassOf obo:GO_0009605, obo:GO_0009607 . obo:GO_0043209 obo:IAO_0000115 "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." ; oboInOwl:hasDbXref "FMA:62983", "NIF_Subcellular:sao593830697", "Wikipedia:Myelin" ; oboInOwl:hasNarrowSynonym "Schwann cell myelin sheath", "astrocyte sheath", "oligodendrocyte myelin sheath" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043209" ; a owl:Class ; rdfs:label "myelin sheath" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0043217 obo:IAO_0000115 "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." ; oboInOwl:hasExactSynonym "myelin sheath maintenance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043217" ; a owl:Class ; rdfs:label "myelin maintenance" ; rdfs:subClassOf obo:GO_0007009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042552 ] . obo:GO_0043226 obo:IAO_0000115 "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." ; oboInOwl:hasDbXref "NIF_Subcellular:sao1539965131", "Wikipedia:Organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043226" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic, go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:label "organelle" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0043227 obo:IAO_0000115 "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." ; oboInOwl:hasDbXref "NIF_Subcellular:sao414196390" ; oboInOwl:hasExactSynonym "membrane-enclosed organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043227" ; a owl:Class ; rdfs:label "membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043226, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0016020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0016020 ] ) ] . obo:GO_0043228 obo:IAO_0000115 "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21881"^^xsd:anyURI ; oboInOwl:hasDbXref "NIF_Subcellular:sao1456184038" ; oboInOwl:hasExactSynonym "non-membrane-enclosed organelle" ; oboInOwl:hasNarrowSynonym "biological condensate" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043228" ; oboInOwl:inSubset go:goslim_mouse ; a owl:Class ; rdfs:label "non-membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043226 . obo:GO_0043229 obo:IAO_0000115 "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043229" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "intracellular organelle" ; rdfs:subClassOf obo:GO_0043226, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0043230 obo:IAO_0000115 "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043230" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "extracellular organelle" ; rdfs:subClassOf obo:GO_0043226, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_0043231 obo:IAO_0000115 "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." ; oboInOwl:hasExactSynonym "intracellular membrane-enclosed organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043231" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "intracellular membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043227, obo:GO_0043229 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043227 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0043232 obo:IAO_0000115 "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." ; oboInOwl:hasExactSynonym "intracellular non-membrane-enclosed organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043232" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "intracellular non-membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043228, obo:GO_0043229 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043228 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0043233 obo:IAO_0000115 "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043233" ; oboInOwl:inSubset go:goslim_mouse ; a owl:Class ; rdfs:label "organelle lumen" ; rdfs:subClassOf obo:GO_0031974, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031974 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043226 ] ) ] . obo:GO_0043235 obo:IAO_0000115 "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043235" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "receptor complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0043255 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." ; oboInOwl:hasExactSynonym "regulation of carbohydrate anabolism", "regulation of carbohydrate biosynthesis", "regulation of carbohydrate formation", "regulation of carbohydrate synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043255" ; a owl:Class ; rdfs:label "regulation of carbohydrate biosynthetic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0009889, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016051 ] ) ] . obo:GO_0043264 obo:IAO_0000115 "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." ; oboInOwl:hasExactSynonym "extracellular non-membrane-enclosed organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043264" ; a owl:Class ; rdfs:label "extracellular non-membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043228, obo:GO_0043230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043228 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_0043269 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasBroadSynonym "regulation of ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043269" ; a owl:Class ; rdfs:label "regulation of monoatomic ion transport" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006811 ] ) ] . obo:GO_0043270 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of ion transport", "up-regulation of ion transport", "upregulation of ion transport" ; oboInOwl:hasNarrowSynonym "activation of ion transport", "stimulation of ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043270" ; a owl:Class ; rdfs:label "positive regulation of monoatomic ion transport" ; rdfs:subClassOf obo:GO_0043269, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006811 ] ) ] . obo:GO_0043271 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasBroadSynonym "negative regulation of ion transport" ; oboInOwl:hasExactSynonym "down regulation of ion transport", "down-regulation of ion transport", "downregulation of ion transport" ; oboInOwl:hasNarrowSynonym "inhibition of ion transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043271" ; a owl:Class ; rdfs:label "negative regulation of monoatomic ion transport" ; rdfs:subClassOf obo:GO_0043269, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006811 ] ) ] . obo:GO_0043292 obo:IAO_0000115 "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." ; oboInOwl:hasExactSynonym "contractile fibre" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043292" ; a owl:Class ; rdfs:label "contractile fiber" ; rdfs:subClassOf obo:GO_0043232, obo:GO_0099512, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] . obo:GO_0043368 obo:IAO_0000115 "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." ; oboInOwl:hasExactSynonym "positive T lymphocyte selection", "positive T-cell selection", "positive T-lymphocyte selection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043368" ; a owl:Class ; rdfs:label "positive T cell selection" ; rdfs:subClassOf obo:GO_0045058 . obo:GO_0043379 obo:IAO_0000115 "The process in which a newly activated T cell acquires specialized features of a memory T cell." ; oboInOwl:hasExactSynonym "memory T lymphocyte differentiation", "memory T-cell differentiation", "memory T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "memory T cell development" ; oboInOwl:id "GO:0043379" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "memory T cell differentiation" ; rdfs:subClassOf obo:GO_0002292, obo:GO_0090715 . obo:GO_0043380 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." ; oboInOwl:hasExactSynonym "regulation of memory T lymphocyte differentiation", "regulation of memory T-cell differentiation", "regulation of memory T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of memory T cell development" ; oboInOwl:id "GO:0043380" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "regulation of memory T cell differentiation" ; rdfs:subClassOf obo:GO_0002697, obo:GO_0045580, obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043379 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:GO_0043381 obo:IAO_0000115 "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of memory T cell differentiation", "down-regulation of memory T cell differentiation", "downregulation of memory T cell differentiation", "negative regulation of memory T lymphocyte differentiation", "negative regulation of memory T-cell differentiation", "negative regulation of memory T-lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of memory T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of memory T cell development" ; oboInOwl:id "GO:0043381" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "negative regulation of memory T cell differentiation" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0043380, obo:GO_0045581, obo:GO_0050777, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043379 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:GO_0043382 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." ; oboInOwl:hasExactSynonym "positive regulation of memory T lymphocyte differentiation", "positive regulation of memory T-cell differentiation", "positive regulation of memory T-lymphocyte differentiation", "up regulation of memory T cell differentiation", "up-regulation of memory T cell differentiation", "upregulation of memory T cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of memory T cell differentiation", "stimulation of memory T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of memory T cell development" ; oboInOwl:id "GO:0043382" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "positive regulation of memory T cell differentiation" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0043380, obo:GO_0045582, obo:GO_0050778, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043379 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043379 ] ) ] . obo:GO_0043384 obo:IAO_0000115 "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." ; oboInOwl:hasExactSynonym "pre-T lymphocyte receptor complex", "pre-T-cell receptor complex", "pre-T-lymphocyte receptor complex", "pre-TCR complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0043384" ; a owl:Class ; rdfs:label "pre-T cell receptor complex" ; rdfs:subClassOf obo:GO_0098802 . obo:GO_0043412 obo:IAO_0000115 "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043412" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "macromolecule modification" ; rdfs:subClassOf obo:GO_0043170 . obo:GO_0043413 obo:IAO_0000115 "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043413" ; a owl:Class ; rdfs:label "macromolecule glycosylation" ; rdfs:subClassOf obo:GO_0043412, obo:GO_0070085 . obo:GO_0043436 obo:IAO_0000115 "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." ; oboInOwl:hasExactSynonym "keto acid metabolic process", "keto acid metabolism", "ketoacid metabolic process", "ketoacid metabolism", "oxo acid metabolic process", "oxo acid metabolism", "oxoacid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043436" ; a owl:Class ; rdfs:label "oxoacid metabolic process" ; rdfs:subClassOf obo:GO_0006082 . obo:GO_0043455 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." ; oboInOwl:hasExactSynonym "regulation of secondary metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043455" ; a owl:Class ; rdfs:label "regulation of secondary metabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019748 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019748 ] ) ] . obo:GO_0043467 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043467" ; a owl:Class ; rdfs:label "regulation of generation of precursor metabolites and energy" ; rdfs:subClassOf obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006091 ] ) ] . obo:GO_0043470 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043470" ; a owl:Class ; rdfs:label "regulation of carbohydrate catabolic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0009894, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016052 ] ) ] . obo:GO_0043473 obo:IAO_0000115 "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043473" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_pir ; a owl:Class ; rdfs:label "pigmentation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0043474 obo:IAO_0000115 "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pigment metabolic process during pigmentation", "pigment metabolism during pigmentation" ; oboInOwl:id "GO:0043474" ; a owl:Class ; rdfs:label "pigment metabolic process involved in pigmentation" ; rdfs:subClassOf obo:GO_0042440, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043473 ] ) ] . obo:GO_0043504 obo:IAO_0000115 "The process of restoring mitochondrial DNA after damage." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043504" ; a owl:Class ; rdfs:label "mitochondrial DNA repair" ; rdfs:subClassOf obo:GO_0006281, obo:GO_0032042 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006281 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0043549 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043549" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of kinase activity" ; rdfs:subClassOf obo:GO_0042325, obo:GO_0051338, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016301 ] ) ] . obo:GO_0043555 obo:IAO_0000115 "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." ; oboInOwl:hasExactSynonym "translational stress response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043555" ; a owl:Class ; rdfs:label "regulation of translation in response to stress" ; rdfs:subClassOf obo:GO_0006417, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0033554 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0033554 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0043576 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043576" ; a owl:Class ; rdfs:label "regulation of respiratory gaseous exchange" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007585 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:GO_0043588 obo:IAO_0000115 "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." ; oboInOwl:hasExactSynonym "animal skin development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043588" ; a owl:Class ; rdfs:label "skin development" ; rdfs:subClassOf obo:GO_0048513 . obo:GO_0043603 obo:IAO_0000115 "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." ; oboInOwl:hasExactSynonym "amide metabolism", "cellular amide metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043603" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "amide metabolic process" ; rdfs:subClassOf obo:GO_0006807 . obo:GO_0043604 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043604" ; a owl:Class ; rdfs:label "amide biosynthetic process" ; rdfs:subClassOf obo:GO_0043603, obo:GO_0044271 . obo:GO_0043648 obo:IAO_0000115 "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." ; oboInOwl:hasExactSynonym "dicarboxylate metabolic process", "dicarboxylate metabolism", "dicarboxylic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043648" ; a owl:Class ; rdfs:label "dicarboxylic acid metabolic process" ; rdfs:subClassOf obo:GO_0019752 . obo:GO_0043891 obo:IAO_0000115 "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." ; oboInOwl:hasDbXref "EC:1.2.1.59", "MetaCyc:GAPDHSYNEC-RXN" ; oboInOwl:hasExactSynonym "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)", "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)", "triosephosphate dehydrogenase (NAD(P))" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:hasRelatedSynonym "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity", "triosephosphate dehydrogenase (NAD(P)+)" ; oboInOwl:id "GO:0043891" ; a owl:Class ; rdfs:label "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity" ; rdfs:subClassOf obo:GO_0016620 . obo:GO_0043903 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19028"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/20191"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "regulation of interspecies interactions between organisms" ; oboInOwl:hasExactSynonym "regulation of symbiotic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of symbiosis, encompassing mutualism through parasitism" ; oboInOwl:id "GO:0043903" ; a owl:Class ; rdfs:comment "regulation of interspecies interactions between organisms" ; rdfs:label "regulation of biological process involved in symbiotic interaction" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044403 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044403 ] ) ] . obo:GO_0043931 obo:IAO_0000115 "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." ; oboInOwl:hasExactSynonym "ossification involved in skeletal development" ; oboInOwl:hasNarrowSynonym "ossification involved in bone modeling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0043931" ; a owl:Class ; rdfs:label "ossification involved in bone maturation" ; rdfs:subClassOf obo:GO_0001503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0070977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0070977 ] ) ] . obo:GO_0043932 obo:IAO_0000115 "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ossification involved in bone remodelling" ; oboInOwl:id "GO:0043932" ; a owl:Class ; rdfs:label "ossification involved in bone remodeling" ; rdfs:subClassOf obo:GO_0001503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0046849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0046849 ] ) ] . obo:GO_0043933 obo:IAO_0000115 "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22580"^^xsd:anyURI ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-08T10:01:42Z" ; oboInOwl:hasAlternativeId "GO:0034600", "GO:0034621", "GO:0071822" ; oboInOwl:hasExactSynonym "protein complex subunit organisation", "protein complex subunit organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cellular macromolecular complex organization", "cellular macromolecular complex subunit organisation", "cellular macromolecular complex subunit organization", "macromolecular complex organization", "macromolecular complex subunit organisation", "macromolecular complex subunit organization", "protein-containing complex subunit organization" ; oboInOwl:id "GO:0043933" ; a owl:Class ; rdfs:label "protein-containing complex organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0044042 obo:IAO_0000115 "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." ; oboInOwl:hasExactSynonym "glucan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044042" ; a owl:Class ; rdfs:label "glucan metabolic process" ; rdfs:subClassOf obo:GO_0005976 . obo:GO_0044057 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044057" ; a owl:Class ; rdfs:label "regulation of system process" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003008 ] ) ] . obo:GO_0044058 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044058" ; a owl:Class ; rdfs:label "regulation of digestive system process" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022600 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022600 ] ) ] . obo:GO_0044060 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." ; oboInOwl:hasExactSynonym "regulation of endocrine system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044060" ; a owl:Class ; rdfs:label "regulation of endocrine process" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050886 ] ) ] . obo:GO_0044062 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044062" ; a owl:Class ; rdfs:label "regulation of excretion" ; rdfs:subClassOf obo:GO_0044057, obo:GO_0051046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007588 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007588 ] ) ] . obo:GO_0044065 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044065" ; a owl:Class ; rdfs:label "regulation of respiratory system process" ; rdfs:subClassOf obo:GO_0043576, obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003016 ] ) ] . obo:GO_0044085 obo:IAO_0000115 "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." ; oboInOwl:hasAlternativeId "GO:0071843" ; oboInOwl:hasExactSynonym "cellular component biogenesis at cellular level" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044085" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular component biogenesis" ; rdfs:subClassOf obo:GO_0071840 . obo:GO_0044087 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044087" ; a owl:Class ; rdfs:label "regulation of cellular component biogenesis" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044085 ] ) ] . obo:GO_0044089 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044089" ; a owl:Class ; rdfs:label "positive regulation of cellular component biogenesis" ; rdfs:subClassOf obo:GO_0044087, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044085 ] ) ] . obo:GO_0044092 obo:IAO_0000115 "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2009-04-21T04:07:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044092" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of molecular function" ; rdfs:subClassOf obo:GO_0065009, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003674 ] ) ] . obo:GO_0044093 obo:IAO_0000115 "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2009-04-21T04:11:06Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044093" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of molecular function" ; rdfs:subClassOf obo:GO_0065009, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003674 ] ) ] . obo:GO_0044237 obo:IAO_0000115 "The chemical reactions and pathways by which individual cells transform chemical substances." ; oboInOwl:hasExactSynonym "cellular metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intermediary metabolism" ; oboInOwl:id "GO:0044237" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ; rdfs:label "cellular metabolic process" ; rdfs:subClassOf obo:GO_0008152, obo:GO_0009987 . obo:GO_0044238 obo:IAO_0000115 "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." ; oboInOwl:hasExactSynonym "primary metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044238" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "primary metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0044248 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "cellular breakdown", "cellular catabolism", "cellular degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044248" ; a owl:Class ; rdfs:label "cellular catabolic process" ; rdfs:subClassOf obo:GO_0009056, obo:GO_0044237 . obo:GO_0044249 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." ; oboInOwl:hasExactSynonym "cellular anabolism", "cellular biosynthesis", "cellular formation", "cellular synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044249" ; a owl:Class ; rdfs:label "cellular biosynthetic process" ; rdfs:subClassOf obo:GO_0009058, obo:GO_0044237 . obo:GO_0044255 obo:IAO_0000115 "The chemical reactions and pathways involving lipids, as carried out by individual cells." ; oboInOwl:hasExactSynonym "cellular lipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044255" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular lipid metabolic process" ; rdfs:subClassOf obo:GO_0006629, obo:GO_0044237 . obo:GO_0044271 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." ; oboInOwl:hasBroadSynonym "nitrogen compound anabolism", "nitrogen compound biosynthesis", "nitrogen compound formation", "nitrogen compound synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044271" ; a owl:Class ; rdfs:label "cellular nitrogen compound biosynthetic process" ; rdfs:subClassOf obo:GO_0034641, obo:GO_0044249 . obo:GO_0044272 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." ; oboInOwl:hasExactSynonym "sulfur compound anabolism", "sulfur compound biosynthesis", "sulfur compound formation", "sulfur compound synthesis" ; oboInOwl:hasNarrowSynonym "sulfur biosynthesis", "sulfur biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044272" ; a owl:Class ; rdfs:label "sulfur compound biosynthetic process" ; rdfs:subClassOf obo:GO_0006790, obo:GO_0044249 . obo:GO_0044281 obo:IAO_0000115 "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-01-26T12:05:20Z" ; oboInOwl:hasExactSynonym "small molecule metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044281" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_metagenomics ; a owl:Class ; rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ; rdfs:label "small molecule metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0044282 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-01-26T12:06:10Z" ; oboInOwl:hasExactSynonym "small molecule catabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044282" ; a owl:Class ; rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ; rdfs:label "small molecule catabolic process" ; rdfs:subClassOf obo:GO_0009056, obo:GO_0044281 . obo:GO_0044283 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-01-26T12:06:49Z" ; oboInOwl:hasExactSynonym "small molecule biosynthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044283" ; oboInOwl:inSubset go:prokaryote_subset ; a owl:Class ; rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ; rdfs:label "small molecule biosynthetic process" ; rdfs:subClassOf obo:GO_0009058, obo:GO_0044281 . obo:GO_0044297 obo:IAO_0000115 "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." ; obo:RO_0002161 obo:NCBITaxon_4890 ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-02-05T10:37:16Z" ; oboInOwl:hasDbXref "FBbt:00005107", "FMA:67301", "Wikipedia:Cell_body" ; oboInOwl:hasExactSynonym "cell soma" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0044297" ; a owl:Class ; rdfs:comment "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ; rdfs:label "cell body" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0044307 obo:IAO_0000115 "A dendrite arising from another dendrite." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-02-05T04:18:53Z" ; oboInOwl:hasDbXref "NIF_Subcellular:sao884265541" ; oboInOwl:hasExactSynonym "dendrite branch" ; oboInOwl:hasNarrowSynonym "secondary dendrite" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0044307" ; a owl:Class ; rdfs:label "dendritic branch" ; rdfs:subClassOf obo:GO_0030425 . obo:GO_0044403 obo:IAO_0000115 "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14807"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/20191"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0043298", "GO:0044404", "GO:0072519", "GO:0085031" ; oboInOwl:hasNarrowSynonym "commensalism", "host-pathogen interaction", "parasitism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "symbiosis", "symbiosis, encompassing mutualism through parasitism", "symbiotic interaction", "symbiotic interaction between host and organism", "symbiotic interaction between organisms", "symbiotic interaction between species", "symbiotic process" ; oboInOwl:id "GO:0044403" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:label "biological process involved in symbiotic interaction" ; rdfs:subClassOf obo:GO_0044419 . obo:GO_0044419 obo:IAO_0000115 "Any process evolved to enable an interaction with an organism of a different species." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20191"^^xsd:anyURI ; obo:RO_0002161 obo:NCBITaxon_4895 ; oboInOwl:hasExactSynonym "interaction with another species", "interspecies interaction", "interspecies interaction between organisms", "interspecies interaction with other organisms" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044419" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_candida, go:goslim_pir ; a owl:Class ; rdfs:label "biological process involved in interspecies interaction between organisms" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0044458 obo:IAO_0000115 "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2015-02-06T17:23:23Z" ; oboInOwl:hasAlternativeId "GO:1903887" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "motile primary cilia assembly", "motile primary cilia formation", "motile primary cilium assembly", "motile primary cilium formation", "nodal cilium assembly", "nodal cilium formation" ; oboInOwl:id "GO:0044458" ; a owl:Class ; rdfs:label "motile cilium assembly" ; rdfs:subClassOf obo:GO_0060271 . obo:GO_0044703 obo:IAO_0000115 "A biological process that directly contributes to the process of producing new individuals, involving another organism." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T15:56:30Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044703" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "multi-organism reproductive process" ; rdfs:subClassOf obo:GO_0022414 . obo:GO_0044706 obo:IAO_0000115 "A multicellular organism process which involves another multicellular organism of the same or different species." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21459"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-09-19T16:06:16Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044706" ; a owl:Class ; rdfs:label "multi-multicellular organism process" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0044782 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-03-27T15:09:58Z" ; oboInOwl:hasExactSynonym "microtubule-based flagellum organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044782" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "cilium organization" ; rdfs:subClassOf obo:GO_0006996, obo:GO_0120036 . obo:GO_0044848 obo:IAO_0000115 "A distinct period or stage in a biological process or cycle." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-07-16T13:12:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0044848" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase." ; rdfs:label "biological phase" ; rdfs:subClassOf obo:GO_0008150 ; owl:disjointWith obo:GO_0046879, obo:GO_0048511, obo:GO_0050896, obo:GO_0051179, obo:GO_0071840 . obo:GO_0045058 obo:IAO_0000115 "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." ; oboInOwl:hasDbXref "Wikipedia:Thymocyte" ; oboInOwl:hasExactSynonym "T lymphocyte selection", "T-cell selection", "T-lymphocyte selection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045058" ; a owl:Class ; rdfs:label "T cell selection" ; rdfs:subClassOf obo:GO_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030217 ] . obo:GO_0045087 obo:IAO_0000115 "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." ; obo:RO_0002161 obo:NCBITaxon_Union_0000023 ; oboInOwl:hasAlternativeId "GO:0002226" ; oboInOwl:hasDbXref "Wikipedia:Innate_immune_system" ; oboInOwl:hasExactSynonym "innate immunity", "nonspecific immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045087" ; a owl:Class ; rdfs:label "innate immune response" ; rdfs:subClassOf obo:GO_0006955, obo:GO_0098542 . obo:GO_0045088 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045088" ; a owl:Class ; rdfs:label "regulation of innate immune response" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0031347, obo:GO_0032101, obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:GO_0045089 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." ; oboInOwl:hasExactSynonym "up regulation of innate immune response", "up-regulation of innate immune response", "upregulation of innate immune response" ; oboInOwl:hasNarrowSynonym "stimulation of innate immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045089" ; a owl:Class ; rdfs:label "positive regulation of innate immune response" ; rdfs:subClassOf obo:GO_0002833, obo:GO_0031349, obo:GO_0032103, obo:GO_0045088, obo:GO_0050778, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:GO_0045095 obo:IAO_0000115 "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "acidic keratin", "basic/neutral keratin" ; oboInOwl:id "GO:0045095" ; a owl:Class ; rdfs:label "keratin filament" ; rdfs:subClassOf obo:GO_0005882 . obo:GO_0045111 obo:IAO_0000115 "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0045111" ; a owl:Class ; rdfs:label "intermediate filament cytoskeleton" ; rdfs:subClassOf obo:GO_0005856 . obo:GO_0045124 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045124" ; a owl:Class ; rdfs:label "regulation of bone resorption" ; rdfs:subClassOf obo:GO_0046850, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045453 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045453 ] ) ] . obo:GO_0045132 obo:IAO_0000115 "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045132" ; a owl:Class ; rdfs:label "meiotic chromosome segregation" ; rdfs:subClassOf obo:GO_0098813, obo:GO_1903046, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0098813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0140013 ] ) ] . obo:GO_0045136 obo:IAO_0000115 "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045136" ; a owl:Class ; rdfs:label "development of secondary sexual characteristics" ; rdfs:subClassOf obo:GO_0003006 . obo:GO_0045144 obo:IAO_0000115 "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." ; oboInOwl:hasExactSynonym "meiosis II, chromosome segregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045144" ; a owl:Class ; rdfs:label "meiotic sister chromatid segregation" ; rdfs:subClassOf obo:GO_0000819, obo:GO_0045132, obo:GO_0070192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007135 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000819 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007135 ] ) ] . obo:GO_0045184 obo:IAO_0000115 "The directed movement of a protein to a specific location." ; oboInOwl:hasExactSynonym "establishment of protein localisation", "protein positioning", "protein recruitment" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045184" ; a owl:Class ; rdfs:label "establishment of protein localization" ; rdfs:subClassOf obo:GO_0008104, obo:GO_0051234 . obo:GO_0045187 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." ; oboInOwl:hasExactSynonym "regulation of sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045187" ; a owl:Class ; rdfs:label "regulation of circadian sleep/wake cycle, sleep" ; rdfs:subClassOf obo:GO_0042749, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050802 ] ) ] . obo:GO_0045190 obo:IAO_0000115 "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." ; oboInOwl:hasDbXref "Wikipedia:Immunoglobulin_class_switching" ; oboInOwl:hasExactSynonym "class switch recombination", "class switching", "isotype switch recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045190" ; a owl:Class ; rdfs:comment "Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'." ; rdfs:label "isotype switching" ; rdfs:subClassOf obo:GO_0002204, obo:GO_0002312 . obo:GO_0045191 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of isotype switching." ; oboInOwl:hasExactSynonym "regulation of class switch recombination", "regulation of class switching", "regulation of isotype switch recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045191" ; a owl:Class ; rdfs:label "regulation of isotype switching" ; rdfs:subClassOf obo:GO_0000018, obo:GO_0002637, obo:GO_0002889, obo:GO_0050864, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045190 ] ) ] . obo:GO_0045202 obo:IAO_0000115 "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." ; oboInOwl:hasDbXref "NIF_Subcellular:sao914572699", "Wikipedia:Chemical_synapse" ; oboInOwl:hasExactSynonym "synaptic junction" ; oboInOwl:hasNarrowSynonym "mixed synapse" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "electrotonic synapse" ; oboInOwl:id "GO:0045202" ; oboInOwl:inSubset go:goslim_agr, go:goslim_drosophila, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir, go:goslim_synapse ; a owl:Class ; rdfs:label "synapse" ; rdfs:subClassOf obo:GO_0030054 . obo:GO_0045211 obo:IAO_0000115 "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." ; oboInOwl:hasExactSynonym "post-synaptic membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0045211" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynaptic membrane" ; rdfs:subClassOf obo:GO_0097060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098794 ] . obo:GO_0045229 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." ; oboInOwl:hasExactSynonym "external encapsulating structure organisation", "external encapsulating structure organization and biogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045229" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "external encapsulating structure organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0045259 obo:IAO_0000115 "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." ; oboInOwl:hasAlternativeId "GO:0045255" ; oboInOwl:hasExactSynonym "F1-F0 complex", "hydrogen-translocating F-type ATPase complex", "hydrogen-transporting ATP synthase complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "proton-transporting F-type ATPase complex" ; oboInOwl:id "GO:0045259" ; a owl:Class ; rdfs:label "proton-transporting ATP synthase complex" ; rdfs:subClassOf obo:GO_0016469 . obo:GO_0045260 obo:IAO_0000115 "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." ; oboInOwl:hasAlternativeId "GO:0045256" ; oboInOwl:hasBroadSynonym "hydrogen-translocating F-type ATPase complex", "proton-transporting ATP synthase complex" ; oboInOwl:hasExactSynonym "hydrogen-transporting ATP synthase", "plasma membrane hydrogen-translocating F-type ATPase complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0045260" ; a owl:Class ; rdfs:label "plasma membrane proton-transporting ATP synthase complex" ; rdfs:subClassOf obo:GO_0045259, obo:GO_0098797 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045259 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ) ] . obo:GO_0045321 obo:IAO_0000115 "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." ; oboInOwl:hasDbXref "Wikipedia:Immunologic_activation" ; oboInOwl:hasExactSynonym "immune cell activation", "leucocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045321" ; a owl:Class ; rdfs:label "leukocyte activation" ; rdfs:subClassOf obo:GO_0001775, obo:GO_0002376 . obo:GO_0045453 obo:IAO_0000115 "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." ; oboInOwl:hasDbXref "Wikipedia:Bone_resorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045453" ; a owl:Class ; rdfs:label "bone resorption" ; rdfs:subClassOf obo:GO_0001894, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0046849 ] . obo:GO_0045577 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of B cell differentiation." ; oboInOwl:hasExactSynonym "regulation of B lymphocyte differentiation", "regulation of B-cell differentiation", "regulation of B-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of B cell development" ; oboInOwl:id "GO:0045577" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "regulation of B cell differentiation" ; rdfs:subClassOf obo:GO_0045619, obo:GO_0050864, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030183 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030183 ] ) ] . obo:GO_0045578 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of B cell differentiation", "down-regulation of B cell differentiation", "downregulation of B cell differentiation", "negative regulation of B lymphocyte differentiation", "negative regulation of B-cell differentiation", "negative regulation of B-lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of B cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of B cell development" ; oboInOwl:id "GO:0045578" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "negative regulation of B cell differentiation" ; rdfs:subClassOf obo:GO_0045577, obo:GO_0045620, obo:GO_0050869, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030183 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030183 ] ) ] . obo:GO_0045579 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of B cell differentiation." ; oboInOwl:hasExactSynonym "positive regulation of B lymphocyte differentiation", "positive regulation of B-cell differentiation", "positive regulation of B-lymphocyte differentiation", "up regulation of B cell differentiation", "up-regulation of B cell differentiation", "upregulation of B cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of B cell differentiation", "stimulation of B cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of B cell development" ; oboInOwl:id "GO:0045579" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "positive regulation of B cell differentiation" ; rdfs:subClassOf obo:GO_0045577, obo:GO_0045621, obo:GO_0050871, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030183 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030183 ] ) ] . obo:GO_0045580 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of T cell differentiation." ; oboInOwl:hasExactSynonym "regulation of T lymphocyte differentiation", "regulation of T-cell differentiation", "regulation of T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of T cell development" ; oboInOwl:id "GO:0045580" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "regulation of T cell differentiation" ; rdfs:subClassOf obo:GO_0045619, obo:GO_0050863, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:GO_0045581 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of T cell differentiation", "down-regulation of T cell differentiation", "downregulation of T cell differentiation", "negative regulation of T lymphocyte differentiation", "negative regulation of T-cell differentiation", "negative regulation of T-lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of T cell development" ; oboInOwl:id "GO:0045581" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "negative regulation of T cell differentiation" ; rdfs:subClassOf obo:GO_0045580, obo:GO_0045620, obo:GO_0050868, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:GO_0045582 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of T cell differentiation." ; oboInOwl:hasExactSynonym "positive regulation of T lymphocyte differentiation", "positive regulation of T-cell differentiation", "positive regulation of T-lymphocyte differentiation", "up regulation of T cell differentiation", "up-regulation of T cell differentiation", "upregulation of T cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of T cell differentiation", "stimulation of T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of T cell development" ; oboInOwl:id "GO:0045582" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "positive regulation of T cell differentiation" ; rdfs:subClassOf obo:GO_0045580, obo:GO_0045621, obo:GO_0050870, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030217 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030217 ] ) ] . obo:GO_0045586 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." ; oboInOwl:hasExactSynonym "regulation of gamma-delta T lymphocyte differentiation", "regulation of gamma-delta T-cell differentiation", "regulation of gamma-delta T-lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of gamma-delta T cell development" ; oboInOwl:id "GO:0045586" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "regulation of gamma-delta T cell differentiation" ; rdfs:subClassOf obo:GO_0045580, obo:GO_0046643, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042492 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042492 ] ) ] . obo:GO_0045587 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of gamma-delta T cell differentiation", "down-regulation of gamma-delta T cell differentiation", "downregulation of gamma-delta T cell differentiation", "negative regulation of gamma-delta T lymphocyte differentiation", "negative regulation of gamma-delta T-cell differentiation", "negative regulation of gamma-delta T-lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of gamma-delta T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of gamma-delta T cell development" ; oboInOwl:id "GO:0045587" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "negative regulation of gamma-delta T cell differentiation" ; rdfs:subClassOf obo:GO_0045581, obo:GO_0045586, obo:GO_0046644, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042492 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042492 ] ) ] . obo:GO_0045588 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." ; oboInOwl:hasExactSynonym "positive regulation of gamma-delta T lymphocyte differentiation", "positive regulation of gamma-delta T-cell differentiation", "positive regulation of gamma-delta T-lymphocyte differentiation", "up regulation of gamma-delta T cell differentiation", "up-regulation of gamma-delta T cell differentiation", "upregulation of gamma-delta T cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of gamma-delta T cell differentiation", "stimulation of gamma-delta T cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of gamma-delta T cell development" ; oboInOwl:id "GO:0045588" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "positive regulation of gamma-delta T cell differentiation" ; rdfs:subClassOf obo:GO_0045582, obo:GO_0045586, obo:GO_0046645, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042492 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042492 ] ) ] . obo:GO_0045595 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045595" ; a owl:Class ; rdfs:label "regulation of cell differentiation" ; rdfs:subClassOf obo:GO_0050793, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030154 ] ) ] . obo:GO_0045596 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of cell differentiation", "down-regulation of cell differentiation", "downregulation of cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045596" ; a owl:Class ; rdfs:label "negative regulation of cell differentiation" ; rdfs:subClassOf obo:GO_0045595, obo:GO_0048523, obo:GO_0051093, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030154 ] ) ] . obo:GO_0045597 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell differentiation." ; oboInOwl:hasExactSynonym "up regulation of cell differentiation", "up-regulation of cell differentiation", "upregulation of cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of cell differentiation", "stimulation of cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045597" ; a owl:Class ; rdfs:label "positive regulation of cell differentiation" ; rdfs:subClassOf obo:GO_0045595, obo:GO_0048522, obo:GO_0051094, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030154 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030154 ] ) ] . obo:GO_0045604 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of hypodermal cell differentiation" ; oboInOwl:id "GO:0045604" ; a owl:Class ; rdfs:label "regulation of epidermal cell differentiation" ; rdfs:subClassOf obo:GO_0030856, obo:GO_0045682, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009913 ] ) ] . obo:GO_0045605 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of epidermal cell differentiation", "down-regulation of epidermal cell differentiation", "downregulation of epidermal cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of epidermal cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of hypodermal cell differentiation" ; oboInOwl:id "GO:0045605" ; a owl:Class ; rdfs:label "negative regulation of epidermal cell differentiation" ; rdfs:subClassOf obo:GO_0030857, obo:GO_0045604, obo:GO_0045683, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009913 ] ) ] . obo:GO_0045606 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." ; oboInOwl:hasExactSynonym "up regulation of epidermal cell differentiation", "up-regulation of epidermal cell differentiation", "upregulation of epidermal cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of epidermal cell differentiation", "stimulation of epidermal cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of hypodermal cell differentiation" ; oboInOwl:id "GO:0045606" ; a owl:Class ; rdfs:label "positive regulation of epidermal cell differentiation" ; rdfs:subClassOf obo:GO_0030858, obo:GO_0045604, obo:GO_0045684, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009913 ] ) ] . obo:GO_0045616 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045616" ; a owl:Class ; rdfs:label "regulation of keratinocyte differentiation" ; rdfs:subClassOf obo:GO_0045604, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030216 ] ) ] . obo:GO_0045617 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of keratinocyte differentiation", "down-regulation of keratinocyte differentiation", "downregulation of keratinocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of keratinocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045617" ; a owl:Class ; rdfs:label "negative regulation of keratinocyte differentiation" ; rdfs:subClassOf obo:GO_0045605, obo:GO_0045616, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030216 ] ) ] . obo:GO_0045618 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of keratinocyte differentiation", "up-regulation of keratinocyte differentiation", "upregulation of keratinocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of keratinocyte differentiation", "stimulation of keratinocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045618" ; a owl:Class ; rdfs:label "positive regulation of keratinocyte differentiation" ; rdfs:subClassOf obo:GO_0045606, obo:GO_0045616, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030216 ] ) ] . obo:GO_0045619 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of lymphocyte development" ; oboInOwl:id "GO:0045619" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "regulation of lymphocyte differentiation" ; rdfs:subClassOf obo:GO_0051249, obo:GO_1902105, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:GO_0045620 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of lymphocyte differentiation", "down-regulation of lymphocyte differentiation", "downregulation of lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of lymphocyte development" ; oboInOwl:id "GO:0045620" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "negative regulation of lymphocyte differentiation" ; rdfs:subClassOf obo:GO_0045619, obo:GO_0051250, obo:GO_1902106, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:GO_0045621 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of lymphocyte differentiation", "up-regulation of lymphocyte differentiation", "upregulation of lymphocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of lymphocyte differentiation", "stimulation of lymphocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of lymphocyte development" ; oboInOwl:id "GO:0045621" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "positive regulation of lymphocyte differentiation" ; rdfs:subClassOf obo:GO_0045619, obo:GO_0051251, obo:GO_1902107, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030098 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030098 ] ) ] . obo:GO_0045637 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045637" ; a owl:Class ; rdfs:label "regulation of myeloid cell differentiation" ; rdfs:subClassOf obo:GO_1903706, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030099 ] ) ] . obo:GO_0045638 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of myeloid cell differentiation", "down-regulation of myeloid cell differentiation", "downregulation of myeloid cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of myeloid cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045638" ; a owl:Class ; rdfs:label "negative regulation of myeloid cell differentiation" ; rdfs:subClassOf obo:GO_0045596, obo:GO_0045637, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030099 ] ) ] . obo:GO_0045639 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." ; oboInOwl:hasExactSynonym "up regulation of myeloid cell differentiation", "up-regulation of myeloid cell differentiation", "upregulation of myeloid cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of myeloid cell differentiation", "stimulation of myeloid cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045639" ; a owl:Class ; rdfs:label "positive regulation of myeloid cell differentiation" ; rdfs:subClassOf obo:GO_0045597, obo:GO_0045637, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030099 ] ) ] . obo:GO_0045640 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of basophil differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045640" ; a owl:Class ; rdfs:label "regulation of basophil differentiation" ; rdfs:subClassOf obo:GO_0030852, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:GO_0045641 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." ; oboInOwl:hasExactSynonym "down regulation of basophil differentiation", "down-regulation of basophil differentiation", "downregulation of basophil differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of basophil differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045641" ; a owl:Class ; rdfs:label "negative regulation of basophil differentiation" ; rdfs:subClassOf obo:GO_0030853, obo:GO_0045640, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:GO_0045642 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of basophil differentiation." ; oboInOwl:hasExactSynonym "up regulation of basophil differentiation", "up-regulation of basophil differentiation", "upregulation of basophil differentiation" ; oboInOwl:hasNarrowSynonym "activation of basophil differentiation", "stimulation of basophil differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045642" ; a owl:Class ; rdfs:label "positive regulation of basophil differentiation" ; rdfs:subClassOf obo:GO_0030854, obo:GO_0045640, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030221 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030221 ] ) ] . obo:GO_0045646 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." ; oboInOwl:hasExactSynonym "regulation of RBC differentiation", "regulation of red blood cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045646" ; a owl:Class ; rdfs:label "regulation of erythrocyte differentiation" ; rdfs:subClassOf obo:GO_0045637, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030218 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:GO_0045647 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of erythrocyte differentiation", "down-regulation of erythrocyte differentiation", "downregulation of erythrocyte differentiation", "negative regulation of RBC differentiation", "negative regulation of red blood cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of erythrocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045647" ; a owl:Class ; rdfs:label "negative regulation of erythrocyte differentiation" ; rdfs:subClassOf obo:GO_0045638, obo:GO_0045646, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030218 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:GO_0045648 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." ; oboInOwl:hasExactSynonym "positive regulation of RBC differentiation", "positive regulation of red blood cell differentiation", "up regulation of erythrocyte differentiation", "up-regulation of erythrocyte differentiation", "upregulation of erythrocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of erythrocyte differentiation", "stimulation of erythrocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045648" ; a owl:Class ; rdfs:label "positive regulation of erythrocyte differentiation" ; rdfs:subClassOf obo:GO_0045639, obo:GO_0045646, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030218 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030218 ] ) ] . obo:GO_0045649 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of macrophage differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045649" ; a owl:Class ; rdfs:label "regulation of macrophage differentiation" ; rdfs:subClassOf obo:GO_0002761, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030225 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030225 ] ) ] . obo:GO_0045650 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." ; oboInOwl:hasExactSynonym "down regulation of macrophage differentiation", "down-regulation of macrophage differentiation", "downregulation of macrophage differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of macrophage differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045650" ; a owl:Class ; rdfs:label "negative regulation of macrophage differentiation" ; rdfs:subClassOf obo:GO_0002762, obo:GO_0045649, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030225 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030225 ] ) ] . obo:GO_0045651 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." ; oboInOwl:hasExactSynonym "up regulation of macrophage differentiation", "up-regulation of macrophage differentiation", "upregulation of macrophage differentiation" ; oboInOwl:hasNarrowSynonym "activation of macrophage differentiation", "stimulation of macrophage differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045651" ; a owl:Class ; rdfs:label "positive regulation of macrophage differentiation" ; rdfs:subClassOf obo:GO_0002763, obo:GO_0045649, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030225 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030225 ] ) ] . obo:GO_0045652 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045652" ; a owl:Class ; rdfs:label "regulation of megakaryocyte differentiation" ; rdfs:subClassOf obo:GO_0045637, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030219 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:GO_0045653 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of megakaryocyte differentiation", "down-regulation of megakaryocyte differentiation", "downregulation of megakaryocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of megakaryocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045653" ; a owl:Class ; rdfs:label "negative regulation of megakaryocyte differentiation" ; rdfs:subClassOf obo:GO_0045638, obo:GO_0045652, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030219 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:GO_0045654 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of megakaryocyte differentiation", "up-regulation of megakaryocyte differentiation", "upregulation of megakaryocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of megakaryocyte differentiation", "stimulation of megakaryocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045654" ; a owl:Class ; rdfs:label "positive regulation of megakaryocyte differentiation" ; rdfs:subClassOf obo:GO_0045639, obo:GO_0045652, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030219 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030219 ] ) ] . obo:GO_0045655 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of monocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045655" ; a owl:Class ; rdfs:label "regulation of monocyte differentiation" ; rdfs:subClassOf obo:GO_0002761, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:GO_0045656 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of monocyte differentiation", "down-regulation of monocyte differentiation", "downregulation of monocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of monocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045656" ; a owl:Class ; rdfs:label "negative regulation of monocyte differentiation" ; rdfs:subClassOf obo:GO_0002762, obo:GO_0045655, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:GO_0045657 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of monocyte differentiation", "up-regulation of monocyte differentiation", "upregulation of monocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of monocyte differentiation", "stimulation of monocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045657" ; a owl:Class ; rdfs:label "positive regulation of monocyte differentiation" ; rdfs:subClassOf obo:GO_0002763, obo:GO_0045655, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030224 ] ) ] . obo:GO_0045670 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of osteoclast differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045670" ; a owl:Class ; rdfs:label "regulation of osteoclast differentiation" ; rdfs:subClassOf obo:GO_0002761, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030316 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030316 ] ) ] . obo:GO_0045671 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." ; oboInOwl:hasExactSynonym "down regulation of osteoclast differentiation", "down-regulation of osteoclast differentiation", "downregulation of osteoclast differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of osteoclast differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045671" ; a owl:Class ; rdfs:label "negative regulation of osteoclast differentiation" ; rdfs:subClassOf obo:GO_0002762, obo:GO_0045670, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030316 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030316 ] ) ] . obo:GO_0045672 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." ; oboInOwl:hasExactSynonym "up regulation of osteoclast differentiation", "up-regulation of osteoclast differentiation", "upregulation of osteoclast differentiation" ; oboInOwl:hasNarrowSynonym "activation of osteoclast differentiation", "stimulation of osteoclast differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045672" ; a owl:Class ; rdfs:label "positive regulation of osteoclast differentiation" ; rdfs:subClassOf obo:GO_0002763, obo:GO_0045670, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030316 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030316 ] ) ] . obo:GO_0045682 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of epidermis development." ; oboInOwl:hasExactSynonym "regulation of epidermal development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of hypodermis development" ; oboInOwl:id "GO:0045682" ; a owl:Class ; rdfs:label "regulation of epidermis development" ; rdfs:subClassOf obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008544 ] ) ] . obo:GO_0045683 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." ; oboInOwl:hasExactSynonym "down regulation of epidermis development", "down-regulation of epidermis development", "downregulation of epidermis development", "negative regulation of epidermal development" ; oboInOwl:hasNarrowSynonym "inhibition of epidermis development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of hypodermis development" ; oboInOwl:id "GO:0045683" ; a owl:Class ; rdfs:label "negative regulation of epidermis development" ; rdfs:subClassOf obo:GO_0045682, obo:GO_0051093, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008544 ] ) ] . obo:GO_0045684 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of epidermis development." ; oboInOwl:hasExactSynonym "positive regulation of epidermal development", "up regulation of epidermis development", "up-regulation of epidermis development", "upregulation of epidermis development" ; oboInOwl:hasNarrowSynonym "activation of epidermis development", "stimulation of epidermis development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of hypodermis development" ; oboInOwl:id "GO:0045684" ; a owl:Class ; rdfs:label "positive regulation of epidermis development" ; rdfs:subClassOf obo:GO_0045682, obo:GO_0051094, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008544 ] ) ] . obo:GO_0045685 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glia cell differentiation." ; oboInOwl:hasExactSynonym "regulation of glia cell differentiation", "regulation of neuroglia differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045685" ; a owl:Class ; rdfs:label "regulation of glial cell differentiation" ; rdfs:subClassOf obo:GO_0045595, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010001 ] ) ] . obo:GO_0045686 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." ; oboInOwl:hasExactSynonym "down regulation of glial cell differentiation", "down-regulation of glial cell differentiation", "downregulation of glial cell differentiation", "negative regulation of glia cell differentiation", "negative regulation of neuroglia differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of glial cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045686" ; a owl:Class ; rdfs:label "negative regulation of glial cell differentiation" ; rdfs:subClassOf obo:GO_0014014, obo:GO_0045685, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010001 ] ) ] . obo:GO_0045687 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." ; oboInOwl:hasExactSynonym "positive regulation of glia cell differentiation", "positive regulation of neuroglia differentiation", "up regulation of glial cell differentiation", "up-regulation of glial cell differentiation", "upregulation of glial cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of glial cell differentiation", "stimulation of glial cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045687" ; a owl:Class ; rdfs:label "positive regulation of glial cell differentiation" ; rdfs:subClassOf obo:GO_0014015, obo:GO_0045685, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010001 ] ) ] . obo:GO_0045700 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045700" ; a owl:Class ; rdfs:label "regulation of spermatid nuclear differentiation" ; rdfs:subClassOf obo:GO_0051239, obo:GO_1903353, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007289 ] ) ] . obo:GO_0045701 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." ; oboInOwl:hasExactSynonym "down regulation of spermatid nuclear differentiation", "down-regulation of spermatid nuclear differentiation", "downregulation of spermatid nuclear differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of spermatid nuclear differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045701" ; a owl:Class ; rdfs:label "negative regulation of spermatid nuclear differentiation" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0045596, obo:GO_0045700, obo:GO_0051241, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007289 ] ) ] . obo:GO_0045702 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." ; oboInOwl:hasExactSynonym "up regulation of spermatid nuclear differentiation", "up-regulation of spermatid nuclear differentiation", "upregulation of spermatid nuclear differentiation" ; oboInOwl:hasNarrowSynonym "activation of spermatid nuclear differentiation", "stimulation of spermatid nuclear differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045702" ; a owl:Class ; rdfs:label "positive regulation of spermatid nuclear differentiation" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0045597, obo:GO_0045700, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007289 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007289 ] ) ] . obo:GO_0045719 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." ; oboInOwl:hasExactSynonym "down regulation of glycogen biosynthetic process", "down-regulation of glycogen biosynthetic process", "downregulation of glycogen biosynthetic process", "negative regulation of glycogen anabolism", "negative regulation of glycogen biosynthesis", "negative regulation of glycogen formation", "negative regulation of glycogen synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of glycogen biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045719" ; a owl:Class ; rdfs:label "negative regulation of glycogen biosynthetic process" ; rdfs:subClassOf obo:GO_0005979, obo:GO_0010558, obo:GO_0070874, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005978 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005978 ] ) ] . obo:GO_0045721 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." ; oboInOwl:hasExactSynonym "down regulation of gluconeogenesis", "down-regulation of gluconeogenesis", "downregulation of gluconeogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of gluconeogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045721" ; a owl:Class ; rdfs:label "negative regulation of gluconeogenesis" ; rdfs:subClassOf obo:GO_0006111, obo:GO_0031327, obo:GO_0045912, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006094 ] ) ] . obo:GO_0045722 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." ; oboInOwl:hasExactSynonym "up regulation of gluconeogenesis", "up-regulation of gluconeogenesis", "upregulation of gluconeogenesis" ; oboInOwl:hasNarrowSynonym "activation of gluconeogenesis", "stimulation of gluconeogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045722" ; a owl:Class ; rdfs:label "positive regulation of gluconeogenesis" ; rdfs:subClassOf obo:GO_0006111, obo:GO_0010907, obo:GO_0031328, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006094 ] ) ] . obo:GO_0045724 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." ; oboInOwl:hasBroadSynonym "positive regulation of flagellum assembly" ; oboInOwl:hasExactSynonym "up regulation of cilium assembly", "up-regulation of cilium assembly", "upregulation of cilium assembly" ; oboInOwl:hasNarrowSynonym "activation of cilium assembly", "stimulation of cilium assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of flagellum biogenesis" ; oboInOwl:id "GO:0045724" ; a owl:Class ; rdfs:label "positive regulation of cilium assembly" ; rdfs:subClassOf obo:GO_0120034, obo:GO_1902017, obo:GO_1902117, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060271 ] ) ] . obo:GO_0045725 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." ; oboInOwl:hasExactSynonym "positive regulation of glycogen anabolism", "positive regulation of glycogen biosynthesis", "positive regulation of glycogen formation", "positive regulation of glycogen synthesis", "up regulation of glycogen biosynthetic process", "up-regulation of glycogen biosynthetic process", "upregulation of glycogen biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of glycogen biosynthetic process", "stimulation of glycogen biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045725" ; a owl:Class ; rdfs:label "positive regulation of glycogen biosynthetic process" ; rdfs:subClassOf obo:GO_0005979, obo:GO_0010557, obo:GO_0031328, obo:GO_0070875, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005978 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005978 ] ) ] . obo:GO_0045727 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." ; oboInOwl:hasAlternativeId "GO:0045946" ; oboInOwl:hasExactSynonym "positive regulation of protein anabolism", "positive regulation of protein biosynthesis", "positive regulation of protein biosynthetic process", "positive regulation of protein formation", "positive regulation of protein synthesis", "up regulation of protein biosynthetic process", "up-regulation of protein biosynthetic process", "upregulation of protein biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of protein biosynthetic process", "stimulation of protein biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045727" ; a owl:Class ; rdfs:label "positive regulation of translation" ; rdfs:subClassOf obo:GO_0006417, obo:GO_0010557, obo:GO_0010628, obo:GO_0031328, obo:GO_0034250, obo:GO_0051247, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0045728 obo:IAO_0000115 "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." ; oboInOwl:hasExactSynonym "metabolic burst after phagocytosis", "oxidative burst after phagocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045728" ; a owl:Class ; rdfs:label "respiratory burst after phagocytosis" ; rdfs:subClassOf obo:GO_0002679 . obo:GO_0045729 obo:IAO_0000115 "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." ; oboInOwl:hasExactSynonym "metabolic burst at fertilization", "oxidative burst at fertilization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045729" ; a owl:Class ; rdfs:label "respiratory burst at fertilization" ; rdfs:subClassOf obo:GO_0022414, obo:GO_0045730, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007338 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045730 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:GO_0045730 obo:IAO_0000115 "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasDbXref "Wikipedia:Respiratory_burst" ; oboInOwl:hasExactSynonym "metabolic burst", "oxidative burst" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045730" ; a owl:Class ; rdfs:label "respiratory burst" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0045738 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." ; oboInOwl:hasExactSynonym "down regulation of DNA repair", "down-regulation of DNA repair", "downregulation of DNA repair" ; oboInOwl:hasNarrowSynonym "inhibition of DNA repair" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045738" ; a owl:Class ; rdfs:label "negative regulation of DNA repair" ; rdfs:subClassOf obo:GO_0006282, obo:GO_0048585, obo:GO_0051053, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006281 ] ) ] . obo:GO_0045739 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of DNA repair." ; oboInOwl:hasExactSynonym "up regulation of DNA repair", "up-regulation of DNA repair", "upregulation of DNA repair" ; oboInOwl:hasNarrowSynonym "activation of DNA repair", "stimulation of DNA repair" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045739" ; a owl:Class ; rdfs:label "positive regulation of DNA repair" ; rdfs:subClassOf obo:GO_0006282, obo:GO_0048584, obo:GO_0051054, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006281 ] ) ] . obo:GO_0045744 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." ; oboInOwl:hasExactSynonym "down regulation of G-protein coupled receptor protein signaling pathway", "down-regulation of G-protein coupled receptor protein signaling pathway", "downregulation of G-protein coupled receptor protein signaling pathway", "negative regulation of G protein coupled receptor protein signaling pathway", "negative regulation of G protein coupled receptor protein signalling pathway", "negative regulation of G-protein coupled receptor protein signaling pathway", "negative regulation of G-protein coupled receptor protein signalling pathway", "negative regulation of G-protein-coupled receptor protein signalling pathway", "negative regulation of GPCR protein signaling pathway", "negative regulation of GPCR protein signalling pathway" ; oboInOwl:hasNarrowSynonym "inhibition of G-protein coupled receptor protein signaling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045744" ; a owl:Class ; rdfs:label "negative regulation of G protein-coupled receptor signaling pathway" ; rdfs:subClassOf obo:GO_0008277, obo:GO_0009968, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007186 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007186 ] ) ] . obo:GO_0045745 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." ; oboInOwl:hasExactSynonym "positive regulation of G protein coupled receptor protein signaling pathway", "positive regulation of G protein coupled receptor protein signalling pathway", "positive regulation of G-protein coupled receptor protein signaling pathway", "positive regulation of G-protein coupled receptor protein signalling pathway", "positive regulation of G-protein-coupled receptor protein signaling pathway", "positive regulation of G-protein-coupled receptor protein signalling pathway", "positive regulation of GPCR protein signaling pathway", "positive regulation of GPCR protein signalling pathway", "up regulation of G-protein coupled receptor protein signaling pathway", "up-regulation of G-protein coupled receptor protein signaling pathway", "upregulation of G-protein coupled receptor protein signaling pathway" ; oboInOwl:hasNarrowSynonym "activation of G-protein coupled receptor protein signaling pathway", "stimulation of G-protein coupled receptor protein signaling pathway" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045745" ; a owl:Class ; rdfs:label "positive regulation of G protein-coupled receptor signaling pathway" ; rdfs:subClassOf obo:GO_0008277, obo:GO_0009967, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007186 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007186 ] ) ] . obo:GO_0045759 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." ; oboInOwl:hasExactSynonym "down regulation of action potential", "down-regulation of action potential", "downregulation of action potential" ; oboInOwl:hasNarrowSynonym "inhibition of action potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045759" ; a owl:Class ; rdfs:label "negative regulation of action potential" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0098900, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001508 ] ) ] . obo:GO_0045760 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." ; oboInOwl:hasExactSynonym "up regulation of action potential", "up-regulation of action potential", "upregulation of action potential" ; oboInOwl:hasNarrowSynonym "activation of action potential", "stimulation of action potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045760" ; a owl:Class ; rdfs:label "positive regulation of action potential" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0098900, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001508 ] ) ] . obo:GO_0045763 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." ; oboInOwl:hasExactSynonym "down regulation of amino acid metabolic process", "down-regulation of amino acid metabolic process", "downregulation of amino acid metabolic process", "negative regulation of amino acid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of amino acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045763" ; a owl:Class ; rdfs:label "negative regulation of cellular amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006521, obo:GO_0031324, obo:GO_0033239, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006520 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006520 ] ) ] . obo:GO_0045764 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." ; oboInOwl:hasExactSynonym "positive regulation of amino acid metabolism", "positive regulation of cellular amino acid metabolic process", "up regulation of amino acid metabolic process", "up-regulation of amino acid metabolic process", "upregulation of amino acid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of amino acid metabolic process", "stimulation of amino acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045764" ; a owl:Class ; rdfs:label "positive regulation of amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006521, obo:GO_0031325, obo:GO_0033240, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006520 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006520 ] ) ] . obo:GO_0045765 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of angiogenesis." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045765" ; a owl:Class ; rdfs:label "regulation of angiogenesis" ; rdfs:subClassOf obo:GO_0022603, obo:GO_1901342, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001525 ] ) ] . obo:GO_0045766 obo:IAO_0000115 "Any process that activates or increases angiogenesis." ; oboInOwl:hasExactSynonym "up regulation of angiogenesis", "up-regulation of angiogenesis", "upregulation of angiogenesis" ; oboInOwl:hasNarrowSynonym "activation of angiogenesis", "stimulation of angiogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045766" ; a owl:Class ; rdfs:label "positive regulation of angiogenesis" ; rdfs:subClassOf obo:GO_0045765, obo:GO_1904018, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001525 ] ) ] . obo:GO_0045778 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." ; oboInOwl:hasExactSynonym "positive regulation of bone biosynthesis", "positive regulation of bone formation", "up regulation of ossification", "up-regulation of ossification", "upregulation of ossification" ; oboInOwl:hasNarrowSynonym "activation of ossification", "stimulation of ossification" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045778" ; a owl:Class ; rdfs:label "positive regulation of ossification" ; rdfs:subClassOf obo:GO_0030278, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001503 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001503 ] ) ] . obo:GO_0045779 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." ; oboInOwl:hasExactSynonym "down regulation of bone resorption", "down-regulation of bone resorption", "downregulation of bone resorption" ; oboInOwl:hasNarrowSynonym "inhibition of bone resorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045779" ; a owl:Class ; rdfs:label "negative regulation of bone resorption" ; rdfs:subClassOf obo:GO_0045124, obo:GO_0046851, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045453 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045453 ] ) ] . obo:GO_0045780 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bone resorption." ; oboInOwl:hasExactSynonym "up regulation of bone resorption", "up-regulation of bone resorption", "upregulation of bone resorption" ; oboInOwl:hasNarrowSynonym "activation of bone resorption", "stimulation of bone resorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045780" ; a owl:Class ; rdfs:label "positive regulation of bone resorption" ; rdfs:subClassOf obo:GO_0045124, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045453 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045453 ] ) ] . obo:GO_0045785 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell adhesion." ; oboInOwl:hasExactSynonym "up regulation of cell adhesion", "up-regulation of cell adhesion", "upregulation of cell adhesion" ; oboInOwl:hasNarrowSynonym "activation of cell adhesion", "stimulation of cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045785" ; a owl:Class ; rdfs:label "positive regulation of cell adhesion" ; rdfs:subClassOf obo:GO_0030155, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007155 ] ) ] . obo:GO_0045786 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." ; oboInOwl:hasExactSynonym "down regulation of progression through cell cycle", "down-regulation of progression through cell cycle", "downregulation of progression through cell cycle", "negative regulation of cell cycle progression", "negative regulation of progression through cell cycle" ; oboInOwl:hasNarrowSynonym "inhibition of progression through cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045786" ; a owl:Class ; rdfs:label "negative regulation of cell cycle" ; rdfs:subClassOf obo:GO_0048523, obo:GO_0051726, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007049 ] ) ] . obo:GO_0045787 obo:IAO_0000115 "Any process that activates or increases the rate or extent of progression through the cell cycle." ; oboInOwl:hasExactSynonym "positive regulation of cell cycle progression", "positive regulation of progression through cell cycle", "up regulation of progression through cell cycle", "up-regulation of progression through cell cycle", "upregulation of progression through cell cycle" ; oboInOwl:hasNarrowSynonym "activation of progression through cell cycle", "stimulation of progression through cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045787" ; a owl:Class ; rdfs:label "positive regulation of cell cycle" ; rdfs:subClassOf obo:GO_0048522, obo:GO_0051726, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007049 ] ) ] . obo:GO_0045806 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." ; oboInOwl:hasExactSynonym "down regulation of endocytosis", "down-regulation of endocytosis", "downregulation of endocytosis" ; oboInOwl:hasNarrowSynonym "inhibition of endocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045806" ; a owl:Class ; rdfs:label "negative regulation of endocytosis" ; rdfs:subClassOf obo:GO_0030100, obo:GO_0051051, obo:GO_0051129, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006897 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006897 ] ) ] . obo:GO_0045807 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of endocytosis." ; oboInOwl:hasExactSynonym "up regulation of endocytosis", "up-regulation of endocytosis", "upregulation of endocytosis" ; oboInOwl:hasNarrowSynonym "activation of endocytosis", "stimulation of endocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045807" ; a owl:Class ; rdfs:label "positive regulation of endocytosis" ; rdfs:subClassOf obo:GO_0030100, obo:GO_0051050, obo:GO_0051130, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006897 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006897 ] ) ] . obo:GO_0045818 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." ; oboInOwl:hasExactSynonym "down regulation of glycogen catabolic process", "down-regulation of glycogen catabolic process", "downregulation of glycogen catabolic process", "negative regulation of glycogen breakdown", "negative regulation of glycogen catabolism", "negative regulation of glycogen degradation", "negative regulation of glycogenolysis" ; oboInOwl:hasNarrowSynonym "inhibition of glycogen catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045818" ; a owl:Class ; rdfs:label "negative regulation of glycogen catabolic process" ; rdfs:subClassOf obo:GO_0005981, obo:GO_0031330, obo:GO_0070874, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005980 ] ) ] . obo:GO_0045819 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." ; oboInOwl:hasExactSynonym "positive regulation of glycogen breakdown", "positive regulation of glycogen catabolism", "positive regulation of glycogen degradation", "positive regulation of glycogenolysis", "up regulation of glycogen catabolic process", "up-regulation of glycogen catabolic process", "upregulation of glycogen catabolic process" ; oboInOwl:hasNarrowSynonym "activation of glycogen catabolic process", "stimulation of glycogen catabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045819" ; a owl:Class ; rdfs:label "positive regulation of glycogen catabolic process" ; rdfs:subClassOf obo:GO_0005981, obo:GO_0031331, obo:GO_0070875, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005980 ] ) ] . obo:GO_0045820 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." ; oboInOwl:hasExactSynonym "down regulation of glycolysis", "down-regulation of glycolysis", "downregulation of glycolysis" ; oboInOwl:hasNarrowSynonym "inhibition of glycolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045820" ; a owl:Class ; rdfs:label "negative regulation of glycolytic process" ; rdfs:subClassOf obo:GO_0006110, obo:GO_0009895, obo:GO_0031324, obo:GO_0045912, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006096 ] ) ] . obo:GO_0045821 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of glycolysis." ; oboInOwl:hasExactSynonym "up regulation of glycolysis", "up-regulation of glycolysis", "upregulation of glycolysis" ; oboInOwl:hasNarrowSynonym "activation of glycolysis", "stimulation of glycolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045821" ; a owl:Class ; rdfs:label "positive regulation of glycolytic process" ; rdfs:subClassOf obo:GO_0006110, obo:GO_0031331, obo:GO_0045913, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006096 ] ) ] . obo:GO_0045822 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." ; oboInOwl:hasExactSynonym "down regulation of heart contraction", "down-regulation of heart contraction", "downregulation of heart contraction" ; oboInOwl:hasNarrowSynonym "inhibition of heart contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cardiac contraction" ; oboInOwl:id "GO:0045822" ; a owl:Class ; rdfs:label "negative regulation of heart contraction" ; rdfs:subClassOf obo:GO_0008016, obo:GO_1903523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060047 ] ) ] . obo:GO_0045823 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of heart contraction." ; oboInOwl:hasExactSynonym "positive regulation of cardiac contraction", "up regulation of heart contraction", "up-regulation of heart contraction", "upregulation of heart contraction" ; oboInOwl:hasNarrowSynonym "activation of heart contraction", "stimulation of heart contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045823" ; a owl:Class ; rdfs:label "positive regulation of heart contraction" ; rdfs:subClassOf obo:GO_0008016, obo:GO_1903524, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060047 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060047 ] ) ] . obo:GO_0045824 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." ; oboInOwl:hasExactSynonym "down regulation of innate immune response", "down-regulation of innate immune response", "downregulation of innate immune response" ; oboInOwl:hasNarrowSynonym "inhibition of innate immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045824" ; a owl:Class ; rdfs:label "negative regulation of innate immune response" ; rdfs:subClassOf obo:GO_0002832, obo:GO_0031348, obo:GO_0032102, obo:GO_0045088, obo:GO_0050777, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045087 ] ) ] . obo:GO_0045827 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." ; oboInOwl:hasExactSynonym "down regulation of isoprenoid metabolic process", "down-regulation of isoprenoid metabolic process", "downregulation of isoprenoid metabolic process", "negative regulation of isoprenoid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of isoprenoid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045827" ; a owl:Class ; rdfs:label "negative regulation of isoprenoid metabolic process" ; rdfs:subClassOf obo:GO_0019747, obo:GO_0031324, obo:GO_0045833, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006720 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006720 ] ) ] . obo:GO_0045828 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." ; oboInOwl:hasExactSynonym "positive regulation of isoprenoid metabolism", "up regulation of isoprenoid metabolic process", "up-regulation of isoprenoid metabolic process", "upregulation of isoprenoid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of isoprenoid metabolic process", "stimulation of isoprenoid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045828" ; a owl:Class ; rdfs:label "positive regulation of isoprenoid metabolic process" ; rdfs:subClassOf obo:GO_0019747, obo:GO_0031325, obo:GO_0045834, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006720 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006720 ] ) ] . obo:GO_0045829 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." ; oboInOwl:hasExactSynonym "down regulation of isotype switching", "down-regulation of isotype switching", "downregulation of isotype switching", "negative regulation of class switch recombination", "negative regulation of class switching", "negative regulation of isotype switch recombination" ; oboInOwl:hasNarrowSynonym "inhibition of isotype switching" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045829" ; a owl:Class ; rdfs:label "negative regulation of isotype switching" ; rdfs:subClassOf obo:GO_0002638, obo:GO_0002890, obo:GO_0045191, obo:GO_0045910, obo:GO_0050869, obo:GO_0051093, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045190 ] ) ] . obo:GO_0045830 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of isotype switching." ; oboInOwl:hasExactSynonym "positive regulation of class switch recombination", "positive regulation of class switching", "positive regulation of isotype switch recombination", "up regulation of isotype switching", "up-regulation of isotype switching", "upregulation of isotype switching" ; oboInOwl:hasNarrowSynonym "activation of isotype switching", "stimulation of isotype switching" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045830" ; a owl:Class ; rdfs:label "positive regulation of isotype switching" ; rdfs:subClassOf obo:GO_0002639, obo:GO_0002891, obo:GO_0045191, obo:GO_0045911, obo:GO_0050871, obo:GO_0051094, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045190 ] ) ] . obo:GO_0045833 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." ; oboInOwl:hasExactSynonym "down regulation of lipid metabolic process", "down-regulation of lipid metabolic process", "downregulation of lipid metabolic process", "negative regulation of lipid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of lipid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045833" ; a owl:Class ; rdfs:label "negative regulation of lipid metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0019216, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006629 ] ) ] . obo:GO_0045834 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." ; oboInOwl:hasExactSynonym "positive regulation of lipid metabolism", "up regulation of lipid metabolic process", "up-regulation of lipid metabolic process", "upregulation of lipid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of lipid metabolic process", "stimulation of lipid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045834" ; a owl:Class ; rdfs:label "positive regulation of lipid metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0019216, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006629 ] ) ] . obo:GO_0045835 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." ; oboInOwl:hasExactSynonym "down regulation of meiosis", "down-regulation of meiosis", "downregulation of meiosis", "negative regulation of meiosis" ; oboInOwl:hasNarrowSynonym "inhibition of meiosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045835" ; a owl:Class ; rdfs:label "negative regulation of meiotic nuclear division" ; rdfs:subClassOf obo:GO_0010948, obo:GO_0040020, obo:GO_0051447, obo:GO_0051784, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0140013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0140013 ] ) ] . obo:GO_0045836 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of meiosis." ; oboInOwl:hasExactSynonym "positive regulation of meiosis", "up regulation of meiosis", "up-regulation of meiosis", "upregulation of meiosis" ; oboInOwl:hasNarrowSynonym "activation of meiosis", "stimulation of meiosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045836" ; a owl:Class ; rdfs:label "positive regulation of meiotic nuclear division" ; rdfs:subClassOf obo:GO_0040020, obo:GO_0051446, obo:GO_0051785, obo:GO_0090068, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0140013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0140013 ] ) ] . obo:GO_0045839 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." ; oboInOwl:hasExactSynonym "down regulation of mitosis", "down-regulation of mitosis", "downregulation of mitosis", "negative regulation of mitosis" ; oboInOwl:hasNarrowSynonym "inhibition of mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045839" ; a owl:Class ; rdfs:label "negative regulation of mitotic nuclear division" ; rdfs:subClassOf obo:GO_0007088, obo:GO_0010948, obo:GO_0045930, obo:GO_0051784, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0140014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0140014 ] ) ] . obo:GO_0045840 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mitosis." ; oboInOwl:hasExactSynonym "positive regulation of mitosis", "up regulation of mitosis", "up-regulation of mitosis", "upregulation of mitosis" ; oboInOwl:hasNarrowSynonym "activation of mitosis", "mitogenic activity", "stimulation of mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045840" ; a owl:Class ; rdfs:label "positive regulation of mitotic nuclear division" ; rdfs:subClassOf obo:GO_0007088, obo:GO_0051785, obo:GO_0090068, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0140014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0140014 ] ) ] . obo:GO_0045861 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." ; oboInOwl:hasExactSynonym "down regulation of proteolysis", "down-regulation of proteolysis", "downregulation of proteolysis", "negative regulation of peptidolysis" ; oboInOwl:hasNarrowSynonym "inhibition of proteolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045861" ; a owl:Class ; rdfs:label "negative regulation of proteolysis" ; rdfs:subClassOf obo:GO_0030162, obo:GO_0051248, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006508 ] ) ] . obo:GO_0045862 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." ; oboInOwl:hasExactSynonym "positive regulation of peptidolysis", "up regulation of proteolysis", "up-regulation of proteolysis", "upregulation of proteolysis" ; oboInOwl:hasNarrowSynonym "activation of proteolysis", "stimulation of proteolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045862" ; a owl:Class ; rdfs:label "positive regulation of proteolysis" ; rdfs:subClassOf obo:GO_0030162, obo:GO_0051247, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006508 ] ) ] . obo:GO_0045900 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." ; oboInOwl:hasExactSynonym "down regulation of translational elongation", "down-regulation of translational elongation", "downregulation of translational elongation" ; oboInOwl:hasNarrowSynonym "inhibition of translational elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045900" ; a owl:Class ; rdfs:label "negative regulation of translational elongation" ; rdfs:subClassOf obo:GO_0006448, obo:GO_0017148, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006414 ] ) ] . obo:GO_0045901 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of translational elongation." ; oboInOwl:hasExactSynonym "up regulation of translational elongation", "up-regulation of translational elongation", "upregulation of translational elongation" ; oboInOwl:hasNarrowSynonym "activation of translational elongation", "stimulation of translational elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045901" ; a owl:Class ; rdfs:label "positive regulation of translational elongation" ; rdfs:subClassOf obo:GO_0006448, obo:GO_0045727, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006414 ] ) ] . obo:GO_0045910 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." ; oboInOwl:hasExactSynonym "down regulation of DNA recombination", "down-regulation of DNA recombination", "downregulation of DNA recombination" ; oboInOwl:hasNarrowSynonym "inhibition of DNA recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045910" ; a owl:Class ; rdfs:label "negative regulation of DNA recombination" ; rdfs:subClassOf obo:GO_0000018, obo:GO_0051053, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006310 ] ) ] . obo:GO_0045911 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of DNA recombination." ; oboInOwl:hasExactSynonym "up regulation of DNA recombination", "up-regulation of DNA recombination", "upregulation of DNA recombination" ; oboInOwl:hasNarrowSynonym "activation of DNA recombination", "stimulation of DNA recombination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045911" ; a owl:Class ; rdfs:label "positive regulation of DNA recombination" ; rdfs:subClassOf obo:GO_0000018, obo:GO_0051054, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006310 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006310 ] ) ] . obo:GO_0045912 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." ; oboInOwl:hasExactSynonym "down regulation of carbohydrate metabolic process", "down-regulation of carbohydrate metabolic process", "downregulation of carbohydrate metabolic process", "negative regulation of carbohydrate metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of carbohydrate metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045912" ; a owl:Class ; rdfs:label "negative regulation of carbohydrate metabolic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0009892, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005975 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005975 ] ) ] . obo:GO_0045913 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." ; oboInOwl:hasExactSynonym "positive regulation of carbohydrate metabolism", "up regulation of carbohydrate metabolic process", "up-regulation of carbohydrate metabolic process", "upregulation of carbohydrate metabolic process" ; oboInOwl:hasNarrowSynonym "activation of carbohydrate metabolic process", "stimulation of carbohydrate metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045913" ; a owl:Class ; rdfs:label "positive regulation of carbohydrate metabolic process" ; rdfs:subClassOf obo:GO_0006109, obo:GO_0009893, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005975 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005975 ] ) ] . obo:GO_0045916 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." ; oboInOwl:hasExactSynonym "down regulation of complement activation", "down-regulation of complement activation", "downregulation of complement activation", "negative regulation of complement cascade" ; oboInOwl:hasNarrowSynonym "inhibition of complement activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045916" ; a owl:Class ; rdfs:label "negative regulation of complement activation" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0002921, obo:GO_0030449, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006956 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006956 ] ) ] . obo:GO_0045917 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of complement activation." ; oboInOwl:hasExactSynonym "positive regulation of complement cascade", "up regulation of complement activation", "up-regulation of complement activation", "upregulation of complement activation" ; oboInOwl:hasNarrowSynonym "activation of complement activation", "stimulation of complement activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045917" ; a owl:Class ; rdfs:label "positive regulation of complement activation" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0002922, obo:GO_0030449, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006956 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006956 ] ) ] . obo:GO_0045920 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." ; oboInOwl:hasExactSynonym "down regulation of exocytosis", "down-regulation of exocytosis", "downregulation of exocytosis" ; oboInOwl:hasNarrowSynonym "inhibition of exocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045920" ; a owl:Class ; rdfs:label "negative regulation of exocytosis" ; rdfs:subClassOf obo:GO_0017157, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006887 ] ) ] . obo:GO_0045921 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of exocytosis." ; oboInOwl:hasExactSynonym "up regulation of exocytosis", "up-regulation of exocytosis", "upregulation of exocytosis" ; oboInOwl:hasNarrowSynonym "activation of exocytosis", "stimulation of exocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045921" ; a owl:Class ; rdfs:label "positive regulation of exocytosis" ; rdfs:subClassOf obo:GO_0017157, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006887 ] ) ] . obo:GO_0045922 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." ; oboInOwl:hasExactSynonym "down regulation of fatty acid metabolic process", "down-regulation of fatty acid metabolic process", "downregulation of fatty acid metabolic process", "negative regulation of fatty acid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of fatty acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045922" ; a owl:Class ; rdfs:label "negative regulation of fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0019217, obo:GO_0031324, obo:GO_0045833, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006631 ] ) ] . obo:GO_0045923 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." ; oboInOwl:hasExactSynonym "positive regulation of fatty acid metabolism", "up regulation of fatty acid metabolic process", "up-regulation of fatty acid metabolic process", "upregulation of fatty acid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of fatty acid metabolic process", "stimulation of fatty acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045923" ; a owl:Class ; rdfs:label "positive regulation of fatty acid metabolic process" ; rdfs:subClassOf obo:GO_0019217, obo:GO_0031325, obo:GO_0045834, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006631 ] ) ] . obo:GO_0045926 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." ; oboInOwl:hasExactSynonym "down regulation of growth", "down-regulation of growth", "downregulation of growth" ; oboInOwl:hasNarrowSynonym "inhibition of growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045926" ; a owl:Class ; rdfs:label "negative regulation of growth" ; rdfs:subClassOf obo:GO_0040008, obo:GO_0048519, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0040007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0040007 ] ) ] . obo:GO_0045927 obo:IAO_0000115 "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." ; oboInOwl:hasExactSynonym "up regulation of growth", "up-regulation of growth", "upregulation of growth" ; oboInOwl:hasNarrowSynonym "activation of growth", "stimulation of growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045927" ; a owl:Class ; rdfs:label "positive regulation of growth" ; rdfs:subClassOf obo:GO_0040008, obo:GO_0048518, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0040007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0040007 ] ) ] . obo:GO_0045930 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." ; oboInOwl:hasExactSynonym "down regulation of progression through mitotic cell cycle", "down-regulation of progression through mitotic cell cycle", "downregulation of progression through mitotic cell cycle", "negative regulation of mitotic cell cycle progression", "negative regulation of progression through mitotic cell cycle" ; oboInOwl:hasNarrowSynonym "inhibition of progression through mitotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045930" ; a owl:Class ; rdfs:label "negative regulation of mitotic cell cycle" ; rdfs:subClassOf obo:GO_0007346, obo:GO_0045786, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_0045931 obo:IAO_0000115 "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." ; oboInOwl:hasExactSynonym "positive regulation of mitotic cell cycle progression", "positive regulation of progression through mitotic cell cycle", "up regulation of progression through mitotic cell cycle", "up-regulation of progression through mitotic cell cycle", "upregulation of progression through mitotic cell cycle" ; oboInOwl:hasNarrowSynonym "activation of progression through mitotic cell cycle", "stimulation of progression through mitotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045931" ; a owl:Class ; rdfs:label "positive regulation of mitotic cell cycle" ; rdfs:subClassOf obo:GO_0007346, obo:GO_0045787, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_0045932 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." ; oboInOwl:hasExactSynonym "down regulation of muscle contraction", "down-regulation of muscle contraction", "downregulation of muscle contraction" ; oboInOwl:hasNarrowSynonym "inhibition of muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045932" ; a owl:Class ; rdfs:label "negative regulation of muscle contraction" ; rdfs:subClassOf obo:GO_0006937, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006936 ] ) ] . obo:GO_0045933 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of muscle contraction." ; oboInOwl:hasExactSynonym "up regulation of muscle contraction", "up-regulation of muscle contraction", "upregulation of muscle contraction" ; oboInOwl:hasNarrowSynonym "activation of muscle contraction", "stimulation of muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045933" ; a owl:Class ; rdfs:label "positive regulation of muscle contraction" ; rdfs:subClassOf obo:GO_0006937, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006936 ] ) ] . obo:GO_0045934 obo:IAO_0000115 "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." ; oboInOwl:hasExactSynonym "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:id "GO:0045934" ; a owl:Class ; rdfs:label "negative regulation of nucleobase-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0019219, obo:GO_0031324, obo:GO_0051172, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006139 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006139 ] ) ] . obo:GO_0045935 obo:IAO_0000115 "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." ; oboInOwl:hasExactSynonym "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" ; oboInOwl:id "GO:0045935" ; a owl:Class ; rdfs:label "positive regulation of nucleobase-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0019219, obo:GO_0031325, obo:GO_0051173, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006139 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006139 ] ) ] . obo:GO_0045936 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." ; oboInOwl:hasExactSynonym "down regulation of phosphate metabolic process", "down-regulation of phosphate metabolic process", "downregulation of phosphate metabolic process", "negative regulation of phosphate metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of phosphate metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045936" ; a owl:Class ; rdfs:label "negative regulation of phosphate metabolic process" ; rdfs:subClassOf obo:GO_0010563, obo:GO_0019220, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006796 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006796 ] ) ] . obo:GO_0045937 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." ; oboInOwl:hasExactSynonym "positive regulation of phosphate metabolism", "up regulation of phosphate metabolic process", "up-regulation of phosphate metabolic process", "upregulation of phosphate metabolic process" ; oboInOwl:hasNarrowSynonym "activation of phosphate metabolic process", "stimulation of phosphate metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045937" ; a owl:Class ; rdfs:label "positive regulation of phosphate metabolic process" ; rdfs:subClassOf obo:GO_0010562, obo:GO_0019220, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006796 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006796 ] ) ] . obo:GO_0045938 obo:IAO_0000115 "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." ; oboInOwl:hasExactSynonym "positive regulation of sleep", "up regulation of circadian sleep/wake cycle, sleep", "up-regulation of circadian sleep/wake cycle, sleep", "upregulation of circadian sleep/wake cycle, sleep" ; oboInOwl:hasNarrowSynonym "activation of circadian sleep/wake cycle, sleep", "stimulation of circadian sleep/wake cycle, sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045938" ; a owl:Class ; rdfs:label "positive regulation of circadian sleep/wake cycle, sleep" ; rdfs:subClassOf obo:GO_0042753, obo:GO_0045187, obo:GO_0048520, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050802 ] ) ] . obo:GO_0045939 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." ; oboInOwl:hasExactSynonym "down regulation of steroid metabolic process", "down-regulation of steroid metabolic process", "downregulation of steroid metabolic process", "negative regulation of steroid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of steroid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045939" ; a owl:Class ; rdfs:label "negative regulation of steroid metabolic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0045833, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008202 ] ) ] . obo:GO_0045940 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." ; oboInOwl:hasExactSynonym "positive regulation of steroid metabolism", "up regulation of steroid metabolic process", "up-regulation of steroid metabolic process", "upregulation of steroid metabolic process" ; oboInOwl:hasNarrowSynonym "activation of steroid metabolic process", "stimulation of steroid metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045940" ; a owl:Class ; rdfs:label "positive regulation of steroid metabolic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0045834, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008202 ] ) ] . obo:GO_0045982 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." ; oboInOwl:hasExactSynonym "down regulation of purine base metabolic process", "down-regulation of purine base metabolic process", "downregulation of purine base metabolic process", "negative regulation of purine base metabolic process", "negative regulation of purine base metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of purine base metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045982" ; a owl:Class ; rdfs:label "negative regulation of purine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0006141, obo:GO_0045934, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006144 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006144 ] ) ] . obo:GO_0045983 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." ; oboInOwl:hasExactSynonym "positive regulation of purine base metabolic process", "positive regulation of purine base metabolism", "up regulation of purine base metabolic process", "up-regulation of purine base metabolic process", "upregulation of purine base metabolic process" ; oboInOwl:hasNarrowSynonym "activation of purine base metabolic process", "stimulation of purine base metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045983" ; a owl:Class ; rdfs:label "positive regulation of purine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0006141, obo:GO_0045935, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006144 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006144 ] ) ] . obo:GO_0045984 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." ; oboInOwl:hasExactSynonym "down regulation of pyrimidine base metabolic process", "down-regulation of pyrimidine base metabolic process", "downregulation of pyrimidine base metabolic process", "negative regulation of pyrimidine base metabolic process", "negative regulation of pyrimidine base metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of pyrimidine base metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045984" ; a owl:Class ; rdfs:label "negative regulation of pyrimidine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0006142, obo:GO_0045934, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006206 ] ) ] . obo:GO_0045985 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." ; oboInOwl:hasExactSynonym "positive regulation of pyrimidine base metabolic process", "positive regulation of pyrimidine base metabolism", "up regulation of pyrimidine base metabolic process", "up-regulation of pyrimidine base metabolic process", "upregulation of pyrimidine base metabolic process" ; oboInOwl:hasNarrowSynonym "activation of pyrimidine base metabolic process", "stimulation of pyrimidine base metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045985" ; a owl:Class ; rdfs:label "positive regulation of pyrimidine nucleobase metabolic process" ; rdfs:subClassOf obo:GO_0006142, obo:GO_0045935, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006206 ] ) ] . obo:GO_0045986 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." ; oboInOwl:hasExactSynonym "down regulation of smooth muscle contraction", "down-regulation of smooth muscle contraction", "downregulation of smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "inhibition of smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "smooth muscle relaxation" ; oboInOwl:id "GO:0045986" ; a owl:Class ; rdfs:label "negative regulation of smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006940, obo:GO_0045932, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006939 ] ) ] . obo:GO_0045987 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." ; oboInOwl:hasExactSynonym "up regulation of smooth muscle contraction", "up-regulation of smooth muscle contraction", "upregulation of smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "activation of smooth muscle contraction", "stimulation of smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045987" ; a owl:Class ; rdfs:label "positive regulation of smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006940, obo:GO_0045933, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006939 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006939 ] ) ] . obo:GO_0045988 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." ; oboInOwl:hasExactSynonym "down regulation of striated muscle contraction", "down-regulation of striated muscle contraction", "downregulation of striated muscle contraction" ; oboInOwl:hasNarrowSynonym "inhibition of striated muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045988" ; a owl:Class ; rdfs:label "negative regulation of striated muscle contraction" ; rdfs:subClassOf obo:GO_0006942, obo:GO_0045932, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006941 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006941 ] ) ] . obo:GO_0045989 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." ; oboInOwl:hasExactSynonym "up regulation of striated muscle contraction", "up-regulation of striated muscle contraction", "upregulation of striated muscle contraction" ; oboInOwl:hasNarrowSynonym "activation of striated muscle contraction", "stimulation of striated muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045989" ; a owl:Class ; rdfs:label "positive regulation of striated muscle contraction" ; rdfs:subClassOf obo:GO_0006942, obo:GO_0045933, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006941 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006941 ] ) ] . obo:GO_0045992 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." ; oboInOwl:hasExactSynonym "down regulation of embryonic development", "down-regulation of embryonic development", "downregulation of embryonic development" ; oboInOwl:hasNarrowSynonym "inhibition of embryonic development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045992" ; a owl:Class ; rdfs:label "negative regulation of embryonic development" ; rdfs:subClassOf obo:GO_0045995, obo:GO_0051093, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009790 ] ) ] . obo:GO_0045995 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of embryonic development." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0045995" ; a owl:Class ; rdfs:label "regulation of embryonic development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009790 ] ) ] . obo:GO_0046005 obo:IAO_0000115 "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." ; oboInOwl:hasExactSynonym "positive regulation of REM sleep", "up regulation of circadian sleep/wake cycle, REM sleep", "up-regulation of circadian sleep/wake cycle, REM sleep", "upregulation of circadian sleep/wake cycle, REM sleep" ; oboInOwl:hasNarrowSynonym "activation of circadian sleep/wake cycle, REM sleep", "stimulation of circadian sleep/wake cycle, REM sleep" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046005" ; a owl:Class ; rdfs:label "positive regulation of circadian sleep/wake cycle, REM sleep" ; rdfs:subClassOf obo:GO_0042320, obo:GO_0045938, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042747 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042747 ] ) ] . obo:GO_0046110 obo:IAO_0000115 "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." ; oboInOwl:hasExactSynonym "xanthine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046110" ; a owl:Class ; rdfs:label "xanthine metabolic process" ; rdfs:subClassOf obo:GO_0006144 . obo:GO_0046136 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." ; oboInOwl:hasExactSynonym "positive regulation of vitamin metabolism", "up regulation of vitamin metabolic process", "up-regulation of vitamin metabolic process", "upregulation of vitamin metabolic process" ; oboInOwl:hasNarrowSynonym "activation of vitamin metabolic process", "stimulation of vitamin metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046136" ; a owl:Class ; rdfs:label "positive regulation of vitamin metabolic process" ; rdfs:subClassOf obo:GO_0030656, obo:GO_0062013, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006766 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006766 ] ) ] . obo:GO_0046137 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." ; oboInOwl:hasExactSynonym "down regulation of vitamin metabolic process", "down-regulation of vitamin metabolic process", "downregulation of vitamin metabolic process", "negative regulation of vitamin metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of vitamin metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046137" ; a owl:Class ; rdfs:label "negative regulation of vitamin metabolic process" ; rdfs:subClassOf obo:GO_0030656, obo:GO_0062014, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006766 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006766 ] ) ] . obo:GO_0046148 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." ; oboInOwl:hasExactSynonym "pigment anabolism", "pigment biosynthesis", "pigment formation", "pigment synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046148" ; a owl:Class ; rdfs:label "pigment biosynthetic process" ; rdfs:subClassOf obo:GO_0042440 . obo:GO_0046185 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." ; oboInOwl:hasExactSynonym "aldehyde breakdown", "aldehyde catabolism", "aldehyde degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046185" ; a owl:Class ; rdfs:label "aldehyde catabolic process" ; rdfs:subClassOf obo:GO_0006081, obo:GO_0044248, obo:GO_1901575 . obo:GO_0046323 obo:IAO_0000115 "The directed movement of the hexose monosaccharide glucose into a cell or organelle." ; oboInOwl:hasDbXref "Wikipedia:Glucose_uptake" ; oboInOwl:hasExactSynonym "glucose uptake" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046323" ; a owl:Class ; rdfs:label "glucose import" ; rdfs:subClassOf obo:GO_1904659 . obo:GO_0046324 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." ; oboInOwl:hasExactSynonym "regulation of glucose uptake" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046324" ; a owl:Class ; rdfs:label "regulation of glucose import" ; rdfs:subClassOf obo:GO_0010827, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046323 ] ) ] . obo:GO_0046325 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." ; oboInOwl:hasExactSynonym "down regulation of glucose import", "down-regulation of glucose import", "downregulation of glucose import", "negative regulation of glucose uptake" ; oboInOwl:hasNarrowSynonym "inhibition of glucose import" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046325" ; a owl:Class ; rdfs:label "negative regulation of glucose import" ; rdfs:subClassOf obo:GO_0010829, obo:GO_0046324, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046323 ] ) ] . obo:GO_0046326 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." ; oboInOwl:hasExactSynonym "positive regulation of glucose uptake", "up regulation of glucose import", "up-regulation of glucose import", "upregulation of glucose import" ; oboInOwl:hasNarrowSynonym "activation of glucose import", "stimulation of glucose import" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046326" ; a owl:Class ; rdfs:label "positive regulation of glucose import" ; rdfs:subClassOf obo:GO_0010828, obo:GO_0046324, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046323 ] ) ] . obo:GO_0046364 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." ; oboInOwl:hasExactSynonym "monosaccharide anabolism", "monosaccharide biosynthesis", "monosaccharide formation", "monosaccharide synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046364" ; a owl:Class ; rdfs:label "monosaccharide biosynthetic process" ; rdfs:subClassOf obo:GO_0005996, obo:GO_0016051, obo:GO_0044283 . obo:GO_0046394 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." ; oboInOwl:hasExactSynonym "carboxylic acid anabolism", "carboxylic acid biosynthesis", "carboxylic acid formation", "carboxylic acid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046394" ; a owl:Class ; rdfs:label "carboxylic acid biosynthetic process" ; rdfs:subClassOf obo:GO_0016053, obo:GO_0019752 . obo:GO_0046483 obo:IAO_0000115 "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." ; oboInOwl:hasExactSynonym "heterocycle metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046483" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "heterocycle metabolic process" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0046541 obo:IAO_0000115 "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." ; oboInOwl:hasDbXref "Wikipedia:Salivation" ; oboInOwl:hasExactSynonym "salivation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046541" ; a owl:Class ; rdfs:label "saliva secretion" ; rdfs:subClassOf obo:GO_0007589, obo:GO_0022600, obo:GO_0032941 . obo:GO_0046543 obo:IAO_0000115 "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046543" ; a owl:Class ; rdfs:label "development of secondary female sexual characteristics" ; rdfs:subClassOf obo:GO_0045136 . obo:GO_0046544 obo:IAO_0000115 "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046544" ; a owl:Class ; rdfs:label "development of secondary male sexual characteristics" ; rdfs:subClassOf obo:GO_0045136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0046661 ] . obo:GO_0046620 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046620" ; a owl:Class ; rdfs:label "regulation of organ growth" ; rdfs:subClassOf obo:GO_0048638, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035265 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035265 ] ) ] . obo:GO_0046621 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046621" ; a owl:Class ; rdfs:label "negative regulation of organ growth" ; rdfs:subClassOf obo:GO_0046620, obo:GO_0048640, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035265 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035265 ] ) ] . obo:GO_0046622 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046622" ; a owl:Class ; rdfs:label "positive regulation of organ growth" ; rdfs:subClassOf obo:GO_0046620, obo:GO_0048639, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035265 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035265 ] ) ] . obo:GO_0046629 obo:IAO_0000115 "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; oboInOwl:hasExactSynonym "gamma-delta T lymphocyte activation", "gamma-delta T-cell activation", "gamma-delta T-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046629" ; a owl:Class ; rdfs:label "gamma-delta T cell activation" ; rdfs:subClassOf obo:GO_0042110 . obo:GO_0046643 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." ; oboInOwl:hasExactSynonym "regulation of gamma-delta T lymphocyte activation", "regulation of gamma-delta T-cell activation", "regulation of gamma-delta T-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046643" ; a owl:Class ; rdfs:label "regulation of gamma-delta T cell activation" ; rdfs:subClassOf obo:GO_0050863, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046629 ] ) ] . obo:GO_0046644 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." ; oboInOwl:hasExactSynonym "down regulation of gamma-delta T cell activation", "down-regulation of gamma-delta T cell activation", "downregulation of gamma-delta T cell activation", "negative regulation of gamma-delta T lymphocyte activation", "negative regulation of gamma-delta T-cell activation", "negative regulation of gamma-delta T-lymphocyte activation" ; oboInOwl:hasNarrowSynonym "inhibition of gamma-delta T cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046644" ; a owl:Class ; rdfs:label "negative regulation of gamma-delta T cell activation" ; rdfs:subClassOf obo:GO_0046643, obo:GO_0050868, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046629 ] ) ] . obo:GO_0046645 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." ; oboInOwl:hasExactSynonym "positive regulation of gamma-delta T lymphocyte activation", "positive regulation of gamma-delta T-cell activation", "positive regulation of gamma-delta T-lymphocyte activation", "up regulation of gamma-delta T cell activation", "up-regulation of gamma-delta T cell activation", "upregulation of gamma-delta T cell activation" ; oboInOwl:hasNarrowSynonym "activation of gamma-delta T cell activation", "stimulation of gamma-delta T cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046645" ; a owl:Class ; rdfs:label "positive regulation of gamma-delta T cell activation" ; rdfs:subClassOf obo:GO_0046643, obo:GO_0050870, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046629 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046629 ] ) ] . obo:GO_0046649 obo:IAO_0000115 "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046649" ; a owl:Class ; rdfs:label "lymphocyte activation" ; rdfs:subClassOf obo:GO_0045321 . obo:GO_0046651 obo:IAO_0000115 "The expansion of a lymphocyte population by cell division." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046651" ; a owl:Class ; rdfs:label "lymphocyte proliferation" ; rdfs:subClassOf obo:GO_0032943, obo:GO_0046649 . obo:GO_0046661 obo:IAO_0000115 "The establishment of the sex of a male organism by physical differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046661" ; a owl:Class ; rdfs:label "male sex differentiation" ; rdfs:subClassOf obo:GO_0007548, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0046676 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." ; oboInOwl:hasExactSynonym "down regulation of insulin secretion", "down-regulation of insulin secretion", "downregulation of insulin secretion" ; oboInOwl:hasNarrowSynonym "inhibition of insulin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046676" ; a owl:Class ; rdfs:label "negative regulation of insulin secretion" ; rdfs:subClassOf obo:GO_0050709, obo:GO_0050796, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:GO_0046717 obo:IAO_0000115 "The controlled release of acid by a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046717" ; a owl:Class ; rdfs:label "acid secretion" ; rdfs:subClassOf obo:GO_0046903 . obo:GO_0046849 obo:IAO_0000115 "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." ; oboInOwl:hasDbXref "Wikipedia:Bone_remodeling" ; oboInOwl:hasExactSynonym "bone remodelling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046849" ; a owl:Class ; rdfs:label "bone remodeling" ; rdfs:subClassOf obo:GO_0048771 . obo:GO_0046850 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046850" ; a owl:Class ; rdfs:label "regulation of bone remodeling" ; rdfs:subClassOf obo:GO_0034103, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046849 ] ) ] . obo:GO_0046851 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." ; oboInOwl:hasExactSynonym "down regulation of bone remodeling", "down-regulation of bone remodeling", "downregulation of bone remodeling" ; oboInOwl:hasNarrowSynonym "inhibition of bone remodeling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046851" ; a owl:Class ; rdfs:label "negative regulation of bone remodeling" ; rdfs:subClassOf obo:GO_0034104, obo:GO_0046850, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046849 ] ) ] . obo:GO_0046852 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bone remodeling." ; oboInOwl:hasExactSynonym "up regulation of bone remodeling", "up-regulation of bone remodeling", "upregulation of bone remodeling" ; oboInOwl:hasNarrowSynonym "activation of bone remodeling", "stimulation of bone remodeling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046852" ; a owl:Class ; rdfs:label "positive regulation of bone remodeling" ; rdfs:subClassOf obo:GO_0034105, obo:GO_0046850, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046849 ] ) ] . obo:GO_0046877 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046877" ; a owl:Class ; rdfs:label "regulation of saliva secretion" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0050878, obo:GO_0051046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046541 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046541 ] ) ] . obo:GO_0046878 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." ; oboInOwl:hasExactSynonym "up regulation of saliva secretion", "up-regulation of saliva secretion", "upregulation of saliva secretion" ; oboInOwl:hasNarrowSynonym "activation of saliva secretion", "stimulation of saliva secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046878" ; a owl:Class ; rdfs:label "positive regulation of saliva secretion" ; rdfs:subClassOf obo:GO_0046877, obo:GO_0051047, obo:GO_0060456, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046541 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046541 ] ) ] . obo:GO_0046879 obo:IAO_0000115 "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046879" ; a owl:Class ; rdfs:label "hormone secretion" ; rdfs:subClassOf obo:GO_0009914, obo:GO_0023061 . obo:GO_0046883 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046883" ; a owl:Class ; rdfs:label "regulation of hormone secretion" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0010817, obo:GO_0023051, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:GO_0046885 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." ; oboInOwl:hasExactSynonym "regulation of hormone anabolism", "regulation of hormone biosynthesis", "regulation of hormone formation", "regulation of hormone synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046885" ; a owl:Class ; rdfs:label "regulation of hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0031326, obo:GO_0032350, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042446 ] ) ] . obo:GO_0046886 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." ; oboInOwl:hasExactSynonym "positive regulation of hormone anabolism", "positive regulation of hormone biosynthesis", "positive regulation of hormone formation", "positive regulation of hormone synthesis", "up regulation of hormone biosynthetic process", "up-regulation of hormone biosynthetic process", "upregulation of hormone biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of hormone biosynthetic process", "stimulation of hormone biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046886" ; a owl:Class ; rdfs:label "positive regulation of hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0031328, obo:GO_0032352, obo:GO_0046885, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042446 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042446 ] ) ] . obo:GO_0046887 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." ; oboInOwl:hasExactSynonym "up regulation of hormone secretion", "up-regulation of hormone secretion", "upregulation of hormone secretion" ; oboInOwl:hasNarrowSynonym "activation of hormone secretion", "stimulation of hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046887" ; a owl:Class ; rdfs:label "positive regulation of hormone secretion" ; rdfs:subClassOf obo:GO_0010647, obo:GO_0023056, obo:GO_0046883, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:GO_0046888 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." ; oboInOwl:hasExactSynonym "down regulation of hormone secretion", "down-regulation of hormone secretion", "downregulation of hormone secretion" ; oboInOwl:hasNarrowSynonym "inhibition of hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046888" ; a owl:Class ; rdfs:label "negative regulation of hormone secretion" ; rdfs:subClassOf obo:GO_0010648, obo:GO_0023057, obo:GO_0046883, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046879 ] ) ] . obo:GO_0046889 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." ; oboInOwl:hasExactSynonym "positive regulation of lipid anabolism", "positive regulation of lipid biosynthesis", "positive regulation of lipid formation", "positive regulation of lipid synthesis", "positive regulation of lipogenesis", "up regulation of lipid biosynthetic process", "up-regulation of lipid biosynthetic process", "upregulation of lipid biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of lipid biosynthetic process", "stimulation of lipid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046889" ; a owl:Class ; rdfs:label "positive regulation of lipid biosynthetic process" ; rdfs:subClassOf obo:GO_0009891, obo:GO_0045834, obo:GO_0046890, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008610 ] ) ] . obo:GO_0046890 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." ; oboInOwl:hasExactSynonym "regulation of lipid anabolism", "regulation of lipid biosynthesis", "regulation of lipid formation", "regulation of lipid synthesis", "regulation of lipogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046890" ; a owl:Class ; rdfs:label "regulation of lipid biosynthetic process" ; rdfs:subClassOf obo:GO_0009889, obo:GO_0019216, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008610 ] ) ] . obo:GO_0046903 obo:IAO_0000115 "The controlled release of a substance by a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046903" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "secretion" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0046907 obo:IAO_0000115 "The directed movement of substances within a cell." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-18T14:04:50Z" ; oboInOwl:hasAlternativeId "GO:1902582" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single organism intracellular transport", "single-organism intracellular transport" ; oboInOwl:id "GO:0046907" ; a owl:Class ; rdfs:label "intracellular transport" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0051641, obo:GO_0051649, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006810 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0046928 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046928" ; a owl:Class ; rdfs:label "regulation of neurotransmitter secretion" ; rdfs:subClassOf obo:GO_0001505, obo:GO_0050804, obo:GO_0051588, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007269 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007269 ] ) ] . obo:GO_0046929 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." ; oboInOwl:hasExactSynonym "down regulation of neurotransmitter secretion", "down-regulation of neurotransmitter secretion", "downregulation of neurotransmitter secretion" ; oboInOwl:hasNarrowSynonym "conotoxin activity", "inhibition of neurotransmitter secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046929" ; a owl:Class ; rdfs:label "negative regulation of neurotransmitter secretion" ; rdfs:subClassOf obo:GO_0046928, obo:GO_0051589, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007269 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007269 ] ) ] . obo:GO_0046942 obo:IAO_0000115 "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046942" ; a owl:Class ; rdfs:label "carboxylic acid transport" ; rdfs:subClassOf obo:GO_0015711, obo:GO_0015849 . obo:GO_0046950 obo:IAO_0000115 "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." ; oboInOwl:hasExactSynonym "cellular ketone body metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046950" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular ketone body metabolic process" ; rdfs:subClassOf obo:GO_0044237, obo:GO_0044281 . obo:GO_0046951 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." ; oboInOwl:hasExactSynonym "ketone body anabolism", "ketone body biosynthesis", "ketone body formation", "ketone body synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0046951" ; a owl:Class ; rdfs:label "ketone body biosynthetic process" ; rdfs:subClassOf obo:GO_0044249, obo:GO_0044283, obo:GO_0046950, obo:GO_1901570, obo:GO_1902224 . obo:GO_0048103 obo:IAO_0000115 "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." ; oboInOwl:hasExactSynonym "somatic stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048103" ; a owl:Class ; rdfs:label "somatic stem cell division" ; rdfs:subClassOf obo:GO_0017145 . obo:GO_0048137 obo:IAO_0000115 "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." ; oboInOwl:hasExactSynonym "spermatocyte cell division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048137" ; a owl:Class ; rdfs:label "spermatocyte division" ; rdfs:subClassOf obo:GO_0022412, obo:GO_0051301, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007283 ] . obo:GO_0048193 obo:IAO_0000115 "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "Golgi-derived vesicle transport" ; oboInOwl:id "GO:0048193" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "Golgi vesicle transport" ; rdfs:subClassOf obo:GO_0016192 . obo:GO_0048199 obo:IAO_0000115 "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." ; oboInOwl:hasExactSynonym "Golgi vesicle targeting" ; oboInOwl:hasNarrowSynonym "dictyosome vesicle targeting", "vesicle targeting, to, from or within dictyosome" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048199" ; a owl:Class ; rdfs:label "vesicle targeting, to, from or within Golgi" ; rdfs:subClassOf obo:GO_0006903, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048193 ] . obo:GO_0048209 obo:IAO_0000115 "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." ; oboInOwl:hasExactSynonym "regulation of Golgi vesicle targeting" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048209" ; a owl:Class ; rdfs:label "regulation of vesicle targeting, to, from or within Golgi" ; rdfs:subClassOf obo:GO_0060341, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048199 ] ) ] . obo:GO_0048232 obo:IAO_0000115 "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048232" ; a owl:Class ; rdfs:label "male gamete generation" ; rdfs:subClassOf obo:GO_0007276 . obo:GO_0048240 obo:IAO_0000115 "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "sperm activation" ; oboInOwl:id "GO:0048240" ; a owl:Class ; rdfs:comment "Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract." ; rdfs:label "sperm capacitation" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0022412, obo:GO_0048469, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007286 ] . obo:GO_0048241 obo:IAO_0000115 "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "adrenaline transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048241" ; a owl:Class ; rdfs:label "epinephrine transport" ; rdfs:subClassOf obo:GO_0051937 . obo:GO_0048242 obo:IAO_0000115 "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." ; oboInOwl:hasExactSynonym "adrenaline secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048242" ; a owl:Class ; rdfs:label "epinephrine secretion" ; rdfs:subClassOf obo:GO_0048241, obo:GO_0050432 . obo:GO_0048243 obo:IAO_0000115 "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." ; oboInOwl:hasExactSynonym "noradrenaline secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048243" ; a owl:Class ; rdfs:label "norepinephrine secretion" ; rdfs:subClassOf obo:GO_0015874, obo:GO_0023061, obo:GO_0050432 . obo:GO_0048284 obo:IAO_0000115 "The creation of a single organelle from two or more organelles." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048284" ; oboInOwl:inSubset go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "organelle fusion" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0048285 obo:IAO_0000115 "The creation of two or more organelles by division of one organelle." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048285" ; oboInOwl:inSubset go:goslim_pir, go:goslim_yeast ; a owl:Class ; rdfs:label "organelle fission" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0048332 obo:IAO_0000115 "The process in which the anatomical structures of the mesoderm are generated and organized." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048332" ; a owl:Class ; rdfs:label "mesoderm morphogenesis" ; rdfs:subClassOf obo:GO_0048729, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007498 ] . obo:GO_0048468 obo:IAO_0000115 "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24390"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "terminal differentiation" ; oboInOwl:id "GO:0048468" ; oboInOwl:inSubset go:goslim_candida ; a owl:Class ; rdfs:label "cell development" ; rdfs:subClassOf obo:GO_0048856, obo:GO_0048869, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030154 ] . obo:GO_0048469 obo:IAO_0000115 "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24390"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "functional differentiation" ; oboInOwl:id "GO:0048469" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cell maturation" ; rdfs:subClassOf obo:GO_0048869, obo:GO_0071695, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048468 ] . obo:GO_0048477 obo:IAO_0000115 "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." ; oboInOwl:hasAlternativeId "GO:0009993", "GO:0048157" ; oboInOwl:hasDbXref "Wikipedia:Oogenesis" ; oboInOwl:hasExactSynonym "ovum development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048477" ; a owl:Class ; rdfs:label "oogenesis" ; rdfs:subClassOf obo:GO_0007281, obo:GO_0007292 . obo:GO_0048511 obo:IAO_0000115 "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "rhythm" ; oboInOwl:id "GO:0048511" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "rhythmic process" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0048512 obo:IAO_0000115 "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." ; oboInOwl:hasExactSynonym "circadian rhythm behavior" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048512" ; a owl:Class ; rdfs:label "circadian behavior" ; rdfs:subClassOf obo:GO_0007622, obo:GO_0007623 . obo:GO_0048513 obo:IAO_0000115 "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." ; oboInOwl:hasDbXref "Wikipedia:Organogenesis" ; oboInOwl:hasExactSynonym "development of an organ", "organogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048513" ; a owl:Class ; rdfs:label "animal organ development" ; rdfs:subClassOf obo:GO_0048856 . obo:GO_0048514 obo:IAO_0000115 "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048514" ; a owl:Class ; rdfs:label "blood vessel morphogenesis" ; rdfs:subClassOf obo:GO_0035239, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001568 ] . obo:GO_0048515 obo:IAO_0000115 "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." ; oboInOwl:hasExactSynonym "spermatid cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048515" ; a owl:Class ; rdfs:label "spermatid differentiation" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0022412, obo:GO_0030154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007283 ] . obo:GO_0048518 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." ; oboInOwl:hasAlternativeId "GO:0043119" ; oboInOwl:hasExactSynonym "positive regulation of physiological process", "up regulation of biological process", "up-regulation of biological process", "upregulation of biological process" ; oboInOwl:hasNarrowSynonym "activation of biological process", "stimulation of biological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048518" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of biological process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008150 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008150 ] ) ] . obo:GO_0048519 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." ; oboInOwl:hasAlternativeId "GO:0043118" ; oboInOwl:hasExactSynonym "down regulation of biological process", "down-regulation of biological process", "downregulation of biological process", "negative regulation of physiological process" ; oboInOwl:hasNarrowSynonym "inhibition of biological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048519" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of biological process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008150 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008150 ] ) ] . obo:GO_0048520 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." ; oboInOwl:hasExactSynonym "up regulation of behavior", "up-regulation of behavior", "upregulation of behavior" ; oboInOwl:hasNarrowSynonym "activation of behavior", "stimulation of behavior" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048520" ; a owl:Class ; rdfs:label "positive regulation of behavior" ; rdfs:subClassOf obo:GO_0050795, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007610 ] ) ] . obo:GO_0048521 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." ; oboInOwl:hasExactSynonym "down regulation of behavior", "down-regulation of behavior", "downregulation of behavior" ; oboInOwl:hasNarrowSynonym "inhibition of behavior" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048521" ; a owl:Class ; rdfs:label "negative regulation of behavior" ; rdfs:subClassOf obo:GO_0050795, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007610 ] ) ] . obo:GO_0048522 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; oboInOwl:hasAlternativeId "GO:0051242" ; oboInOwl:hasExactSynonym "positive regulation of cellular physiological process", "up regulation of cellular process", "up-regulation of cellular process", "upregulation of cellular process" ; oboInOwl:hasNarrowSynonym "activation of cellular process", "stimulation of cellular process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048522" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of cellular process" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009987 ] ) ] . obo:GO_0048523 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; oboInOwl:hasAlternativeId "GO:0051243" ; oboInOwl:hasExactSynonym "down regulation of cellular process", "down-regulation of cellular process", "downregulation of cellular process", "negative regulation of cellular physiological process" ; oboInOwl:hasNarrowSynonym "inhibition of cellular process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048523" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of cellular process" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009987 ] ) ] . obo:GO_0048580 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048580" ; a owl:Class ; rdfs:label "regulation of post-embryonic development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009791 ] ) ] . obo:GO_0048581 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." ; oboInOwl:hasExactSynonym "down regulation of post-embryonic development", "down-regulation of post-embryonic development", "downregulation of post-embryonic development" ; oboInOwl:hasNarrowSynonym "inhibition of post-embryonic development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048581" ; a owl:Class ; rdfs:label "negative regulation of post-embryonic development" ; rdfs:subClassOf obo:GO_0048580, obo:GO_0051093, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009791 ] ) ] . obo:GO_0048582 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." ; oboInOwl:hasExactSynonym "up regulation of post-embryonic development", "up-regulation of post-embryonic development", "upregulation of post-embryonic development" ; oboInOwl:hasNarrowSynonym "activation of post-embryonic development", "stimulation of post-embryonic development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048582" ; a owl:Class ; rdfs:label "positive regulation of post-embryonic development" ; rdfs:subClassOf obo:GO_0048580, obo:GO_0051094, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009791 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009791 ] ) ] . obo:GO_0048583 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048583" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "regulation of response to stimulus" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050896 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050896 ] ) ] . obo:GO_0048584 obo:IAO_0000115 "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." ; oboInOwl:hasExactSynonym "up regulation of response to stimulus", "up-regulation of response to stimulus", "upregulation of response to stimulus" ; oboInOwl:hasNarrowSynonym "activation of response to stimulus", "stimulation of response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048584" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "positive regulation of response to stimulus" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050896 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050896 ] ) ] . obo:GO_0048585 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." ; oboInOwl:hasExactSynonym "down regulation of response to stimulus", "down-regulation of response to stimulus", "downregulation of response to stimulus" ; oboInOwl:hasNarrowSynonym "inhibition of response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048585" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "negative regulation of response to stimulus" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050896 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050896 ] ) ] . obo:GO_0048588 obo:IAO_0000115 "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." ; oboInOwl:hasExactSynonym "developmental growth of a unicellular organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048588" ; a owl:Class ; rdfs:label "developmental cell growth" ; rdfs:subClassOf obo:GO_0016049, obo:GO_0048589, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048468 ] . obo:GO_0048589 obo:IAO_0000115 "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048589" ; a owl:Class ; rdfs:label "developmental growth" ; rdfs:subClassOf obo:GO_0040007, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032502 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0040007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032502 ] ) ] . obo:GO_0048598 obo:IAO_0000115 "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." ; oboInOwl:hasAlternativeId "GO:0048828" ; oboInOwl:hasExactSynonym "embryonic anatomical structure morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048598" ; a owl:Class ; rdfs:label "embryonic morphogenesis" ; rdfs:subClassOf obo:GO_0009653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009790 ] . obo:GO_0048609 obo:IAO_0000115 "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." ; oboInOwl:hasBroadSynonym "organismal reproductive process" ; oboInOwl:hasExactSynonym "reproductive process in a multicellular organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048609" ; a owl:Class ; rdfs:label "multicellular organismal reproductive process" ; rdfs:subClassOf obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032504 ] . obo:GO_0048638 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of developmental growth." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048638" ; a owl:Class ; rdfs:label "regulation of developmental growth" ; rdfs:subClassOf obo:GO_0040008, obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048589 ] ) ] . obo:GO_0048639 obo:IAO_0000115 "Any process that activates, maintains or increases the rate of developmental growth." ; oboInOwl:hasExactSynonym "up regulation of developmental growth", "up-regulation of developmental growth", "upregulation of developmental growth" ; oboInOwl:hasNarrowSynonym "activation of developmental growth", "stimulation of developmental growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048639" ; a owl:Class ; rdfs:label "positive regulation of developmental growth" ; rdfs:subClassOf obo:GO_0045927, obo:GO_0048638, obo:GO_0051094, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048589 ] ) ] . obo:GO_0048640 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." ; oboInOwl:hasExactSynonym "down regulation of developmental growth", "down-regulation of developmental growth", "downregulation of developmental growth" ; oboInOwl:hasNarrowSynonym "inhibition of developmental growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048640" ; a owl:Class ; rdfs:label "negative regulation of developmental growth" ; rdfs:subClassOf obo:GO_0045926, obo:GO_0048638, obo:GO_0051093, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048589 ] ) ] . obo:GO_0048646 obo:IAO_0000115 "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." ; oboInOwl:hasExactSynonym "formation of an anatomical structure involved in morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048646" ; oboInOwl:inSubset go:goslim_chembl ; a owl:Class ; rdfs:comment "Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense." ; rdfs:label "anatomical structure formation involved in morphogenesis" ; rdfs:subClassOf obo:GO_0032502, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] . obo:GO_0048699 obo:IAO_0000115 "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." ; oboInOwl:hasExactSynonym "neuron generation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048699" ; a owl:Class ; rdfs:label "generation of neurons" ; rdfs:subClassOf obo:GO_0022008 . obo:GO_0048705 obo:IAO_0000115 "The process in which the anatomical structures of the skeleton are generated and organized." ; oboInOwl:hasExactSynonym "skeletal morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048705" ; a owl:Class ; rdfs:label "skeletal system morphogenesis" ; rdfs:subClassOf obo:GO_0009887, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001501 ] . obo:GO_0048709 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048709" ; a owl:Class ; rdfs:label "oligodendrocyte differentiation" ; rdfs:subClassOf obo:GO_0010001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007417 ] . obo:GO_0048713 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048713" ; a owl:Class ; rdfs:label "regulation of oligodendrocyte differentiation" ; rdfs:subClassOf obo:GO_0045685, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048709 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048709 ] ) ] . obo:GO_0048714 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." ; oboInOwl:hasExactSynonym "up regulation of oligodendrocyte differentiation", "up-regulation of oligodendrocyte differentiation", "upregulation of oligodendrocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of oligodendrocyte differentiation", "stimulation of oligodendrocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048714" ; a owl:Class ; rdfs:label "positive regulation of oligodendrocyte differentiation" ; rdfs:subClassOf obo:GO_0045687, obo:GO_0048713, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048709 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048709 ] ) ] . obo:GO_0048715 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." ; oboInOwl:hasExactSynonym "down regulation of oligodendrocyte differentiation", "down-regulation of oligodendrocyte differentiation", "downregulation of oligodendrocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of oligodendrocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048715" ; a owl:Class ; rdfs:label "negative regulation of oligodendrocyte differentiation" ; rdfs:subClassOf obo:GO_0045686, obo:GO_0048713, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048709 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048709 ] ) ] . obo:GO_0048729 obo:IAO_0000115 "The process in which the anatomical structures of a tissue are generated and organized." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048729" ; a owl:Class ; rdfs:label "tissue morphogenesis" ; rdfs:subClassOf obo:GO_0009653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009888 ] . obo:GO_0048731 obo:IAO_0000115 "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048731" ; oboInOwl:inSubset go:goslim_mouse ; a owl:Class ; rdfs:label "system development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0048732 obo:IAO_0000115 "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048732" ; a owl:Class ; rdfs:label "gland development" ; rdfs:subClassOf obo:GO_0048513 . obo:GO_0048736 obo:IAO_0000115 "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048736" ; a owl:Class ; rdfs:label "appendage development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007275 ] . obo:GO_0048754 obo:IAO_0000115 "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "tubulogenesis" ; oboInOwl:id "GO:0048754" ; a owl:Class ; rdfs:label "branching morphogenesis of an epithelial tube" ; rdfs:subClassOf obo:GO_0035239, obo:GO_0061138, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060562 ] . obo:GO_0048770 obo:IAO_0000115 "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0048770" ; a owl:Class ; rdfs:label "pigment granule" ; rdfs:subClassOf obo:GO_0031410 . obo:GO_0048771 obo:IAO_0000115 "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048771" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "tissue remodeling" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0048799 obo:IAO_0000115 "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048799" ; a owl:Class ; rdfs:label "animal organ maturation" ; rdfs:subClassOf obo:GO_0071695, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048513 ] . obo:GO_0048845 obo:IAO_0000115 "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." ; oboInOwl:hasBroadSynonym "vein morphogenesis" ; oboInOwl:hasExactSynonym "venous morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048845" ; a owl:Class ; rdfs:label "venous blood vessel morphogenesis" ; rdfs:subClassOf obo:GO_0048514, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060841 ] . obo:GO_0048856 obo:IAO_0000115 "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." ; oboInOwl:hasExactSynonym "development of an anatomical structure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048856" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic, go:goslim_plant ; a owl:Class ; rdfs:label "anatomical structure development" ; rdfs:subClassOf obo:GO_0032502 . obo:GO_0048869 obo:IAO_0000115 "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048869" ; a owl:Class ; rdfs:label "cellular developmental process" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0032502 . obo:GO_0048870 obo:IAO_0000115 "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19809"^^xsd:anyURI ; oboInOwl:hasExactSynonym "cell locomotion", "movement of a cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell movement" ; oboInOwl:id "GO:0048870" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:prokaryote_subset ; a owl:Class ; rdfs:label "cell motility" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0048871 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048871" ; a owl:Class ; rdfs:label "multicellular organismal-level homeostasis" ; rdfs:subClassOf obo:GO_0032501, obo:GO_0042592 . obo:GO_0048872 obo:IAO_0000115 "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24218"^^xsd:anyURI ; oboInOwl:hasExactSynonym "cell population homeostasis", "homeostasis of cell number" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048872" ; a owl:Class ; rdfs:label "homeostasis of number of cells" ; rdfs:subClassOf obo:GO_0048871 . obo:GO_0048873 obo:IAO_0000115 "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048873" ; a owl:Class ; rdfs:label "homeostasis of number of cells within a tissue" ; rdfs:subClassOf obo:GO_0001894, obo:GO_0048872 . obo:GO_0048878 obo:IAO_0000115 "Any biological process involved in the maintenance of an internal steady state of a chemical." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0048878" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "chemical homeostasis" ; rdfs:subClassOf obo:GO_0042592 . obo:GO_0050432 obo:IAO_0000115 "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050432" ; a owl:Class ; rdfs:label "catecholamine secretion" ; rdfs:subClassOf obo:GO_0032940, obo:GO_0051937 . obo:GO_0050433 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050433" ; a owl:Class ; rdfs:label "regulation of catecholamine secretion" ; rdfs:subClassOf obo:GO_0051952, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050432 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050432 ] ) ] . obo:GO_0050666 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." ; oboInOwl:hasExactSynonym "regulation of Hcy metabolic process", "regulation of Hcy metabolism", "regulation of homocysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050666" ; a owl:Class ; rdfs:label "regulation of homocysteine metabolic process" ; rdfs:subClassOf obo:GO_0006521, obo:GO_0031335, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050667 ] ) ] . obo:GO_0050667 obo:IAO_0000115 "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." ; oboInOwl:hasExactSynonym "Hcy metabolic process", "Hcy metabolism", "homocysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050667" ; a owl:Class ; rdfs:label "homocysteine metabolic process" ; rdfs:subClassOf obo:GO_0000096, obo:GO_1901605 . obo:GO_0050668 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." ; oboInOwl:hasExactSynonym "positive regulation of Hcy metabolic process", "positive regulation of Hcy metabolism", "positive regulation of homocysteine metabolism", "up regulation of homocysteine metabolic process", "up-regulation of homocysteine metabolic process", "upregulation of homocysteine metabolic process" ; oboInOwl:hasNarrowSynonym "activation of homocysteine metabolic process", "stimulation of homocysteine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050668" ; a owl:Class ; rdfs:label "positive regulation of homocysteine metabolic process" ; rdfs:subClassOf obo:GO_0031337, obo:GO_0045764, obo:GO_0050666, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050667 ] ) ] . obo:GO_0050669 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." ; oboInOwl:hasExactSynonym "down regulation of homocysteine metabolic process", "down-regulation of homocysteine metabolic process", "downregulation of homocysteine metabolic process", "negative regulation of Hcy metabolic process", "negative regulation of Hcy metabolism", "negative regulation of homocysteine metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of homocysteine metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050669" ; a owl:Class ; rdfs:label "negative regulation of homocysteine metabolic process" ; rdfs:subClassOf obo:GO_0031336, obo:GO_0045763, obo:GO_0050666, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050667 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050667 ] ) ] . obo:GO_0050670 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050670" ; a owl:Class ; rdfs:label "regulation of lymphocyte proliferation" ; rdfs:subClassOf obo:GO_0032944, obo:GO_0051249, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046651 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046651 ] ) ] . obo:GO_0050671 obo:IAO_0000115 "Any process that activates or increases the rate or extent of lymphocyte proliferation." ; oboInOwl:hasExactSynonym "up regulation of lymphocyte proliferation", "up-regulation of lymphocyte proliferation", "upregulation of lymphocyte proliferation" ; oboInOwl:hasNarrowSynonym "activation of lymphocyte proliferation", "stimulation of lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050671" ; a owl:Class ; rdfs:label "positive regulation of lymphocyte proliferation" ; rdfs:subClassOf obo:GO_0032946, obo:GO_0050670, obo:GO_0051251, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046651 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046651 ] ) ] . obo:GO_0050672 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." ; oboInOwl:hasExactSynonym "down regulation of lymphocyte proliferation", "down-regulation of lymphocyte proliferation", "downregulation of lymphocyte proliferation" ; oboInOwl:hasNarrowSynonym "inhibition of lymphocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050672" ; a owl:Class ; rdfs:label "negative regulation of lymphocyte proliferation" ; rdfs:subClassOf obo:GO_0032945, obo:GO_0050670, obo:GO_0051250, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046651 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046651 ] ) ] . obo:GO_0050687 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." ; oboInOwl:hasExactSynonym "down regulation of antiviral response", "down-regulation of antiviral response", "downregulation of antiviral response", "negative regulation of antiviral response" ; oboInOwl:hasNarrowSynonym "inhibition of antiviral response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050687" ; a owl:Class ; rdfs:label "negative regulation of defense response to virus" ; rdfs:subClassOf obo:GO_0002832, obo:GO_0031348, obo:GO_0032102, obo:GO_0050688, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051607 ] ) ] . obo:GO_0050688 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." ; oboInOwl:hasExactSynonym "regulation of antiviral response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050688" ; a owl:Class ; rdfs:label "regulation of defense response to virus" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0031347, obo:GO_0032101, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051607 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051607 ] ) ] . obo:GO_0050708 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050708" ; a owl:Class ; rdfs:label "regulation of protein secretion" ; rdfs:subClassOf obo:GO_0051223, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009306 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009306 ] ) ] . obo:GO_0050709 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." ; oboInOwl:hasExactSynonym "down regulation of protein secretion", "down-regulation of protein secretion", "downregulation of protein secretion" ; oboInOwl:hasNarrowSynonym "inhibition of protein secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050709" ; a owl:Class ; rdfs:label "negative regulation of protein secretion" ; rdfs:subClassOf obo:GO_0050708, obo:GO_0051224, obo:GO_1903531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009306 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009306 ] ) ] . obo:GO_0050714 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." ; oboInOwl:hasExactSynonym "up regulation of protein secretion", "up-regulation of protein secretion", "upregulation of protein secretion" ; oboInOwl:hasNarrowSynonym "activation of protein secretion", "stimulation of protein secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050714" ; a owl:Class ; rdfs:label "positive regulation of protein secretion" ; rdfs:subClassOf obo:GO_0050708, obo:GO_0051222, obo:GO_1903532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009306 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009306 ] ) ] . obo:GO_0050727 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050727" ; a owl:Class ; rdfs:label "regulation of inflammatory response" ; rdfs:subClassOf obo:GO_0031347, obo:GO_0032101, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0050728 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." ; oboInOwl:hasAlternativeId "GO:0030236" ; oboInOwl:hasExactSynonym "anti-inflammatory response", "down regulation of inflammatory response", "down-regulation of inflammatory response", "downregulation of inflammatory response" ; oboInOwl:hasNarrowSynonym "inhibition of inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050728" ; a owl:Class ; rdfs:label "negative regulation of inflammatory response" ; rdfs:subClassOf obo:GO_0031348, obo:GO_0032102, obo:GO_0050727, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0050729 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the inflammatory response." ; oboInOwl:hasExactSynonym "up regulation of inflammatory response", "up-regulation of inflammatory response", "upregulation of inflammatory response" ; oboInOwl:hasNarrowSynonym "activation of inflammatory response", "stimulation of inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050729" ; a owl:Class ; rdfs:label "positive regulation of inflammatory response" ; rdfs:subClassOf obo:GO_0031349, obo:GO_0032103, obo:GO_0050727, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006954 ] ) ] . obo:GO_0050764 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." ; obo:RO_0002161 obo:NCBITaxon_147537 ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050764" ; a owl:Class ; rdfs:label "regulation of phagocytosis" ; rdfs:subClassOf obo:GO_0030100, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006909 ] ) ] . obo:GO_0050765 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." ; oboInOwl:hasExactSynonym "down regulation of phagocytosis", "down-regulation of phagocytosis", "downregulation of phagocytosis" ; oboInOwl:hasNarrowSynonym "inhibition of phagocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050765" ; a owl:Class ; rdfs:label "negative regulation of phagocytosis" ; rdfs:subClassOf obo:GO_0045806, obo:GO_0050764, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006909 ] ) ] . obo:GO_0050766 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of phagocytosis." ; oboInOwl:hasExactSynonym "up regulation of phagocytosis", "up-regulation of phagocytosis", "upregulation of phagocytosis" ; oboInOwl:hasNarrowSynonym "activation of phagocytosis", "stimulation of phagocytosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050766" ; a owl:Class ; rdfs:label "positive regulation of phagocytosis" ; rdfs:subClassOf obo:GO_0045807, obo:GO_0050764, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006909 ] ) ] . obo:GO_0050767 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050767" ; a owl:Class ; rdfs:label "regulation of neurogenesis" ; rdfs:subClassOf obo:GO_0051960, obo:GO_0060284, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022008 ] ) ] . obo:GO_0050768 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." ; oboInOwl:hasExactSynonym "down regulation of neurogenesis", "down-regulation of neurogenesis", "downregulation of neurogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of neurogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050768" ; a owl:Class ; rdfs:label "negative regulation of neurogenesis" ; rdfs:subClassOf obo:GO_0010721, obo:GO_0050767, obo:GO_0051961, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022008 ] ) ] . obo:GO_0050769 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." ; oboInOwl:hasExactSynonym "up regulation of neurogenesis", "up-regulation of neurogenesis", "upregulation of neurogenesis" ; oboInOwl:hasNarrowSynonym "activation of neurogenesis", "stimulation of neurogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050769" ; a owl:Class ; rdfs:label "positive regulation of neurogenesis" ; rdfs:subClassOf obo:GO_0010720, obo:GO_0050767, obo:GO_0051962, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022008 ] ) ] . obo:GO_0050776 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050776" ; a owl:Class ; rdfs:label "regulation of immune response" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0050777 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." ; oboInOwl:hasExactSynonym "down regulation of immune response", "down-regulation of immune response", "downregulation of immune response" ; oboInOwl:hasNarrowSynonym "inhibition of immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050777" ; a owl:Class ; rdfs:label "negative regulation of immune response" ; rdfs:subClassOf obo:GO_0002683, obo:GO_0048585, obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0050778 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." ; oboInOwl:hasExactSynonym "up regulation of immune response", "up-regulation of immune response", "upregulation of immune response" ; oboInOwl:hasNarrowSynonym "stimulation of immune response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050778" ; a owl:Class ; rdfs:label "positive regulation of immune response" ; rdfs:subClassOf obo:GO_0002684, obo:GO_0048584, obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006955 ] ) ] . obo:GO_0050789 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." ; oboInOwl:hasAlternativeId "GO:0050791" ; oboInOwl:hasExactSynonym "regulation of physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050789" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_candida, go:goslim_pir ; a owl:Class ; rdfs:label "regulation of biological process" ; rdfs:subClassOf obo:GO_0065007, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008150 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008150 ] ) ] . obo:GO_0050790 obo:IAO_0000115 "Any process that modulates the activity of an enzyme." ; oboInOwl:hasAlternativeId "GO:0048552" ; oboInOwl:hasExactSynonym "regulation of enzyme activity" ; oboInOwl:hasNarrowSynonym "regulation of metalloenzyme activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050790" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_chembl ; a owl:Class ; rdfs:label "regulation of catalytic activity" ; rdfs:subClassOf obo:GO_0065009, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003824 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003824 ] ) ] . obo:GO_0050793 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050793" ; a owl:Class ; rdfs:label "regulation of developmental process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032502 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032502 ] ) ] . obo:GO_0050794 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ; oboInOwl:hasAlternativeId "GO:0051244" ; oboInOwl:hasExactSynonym "regulation of cellular physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050794" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of cellular process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009987 ] ) ] . obo:GO_0050795 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." ; oboInOwl:hasExactSynonym "regulation of behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050795" ; a owl:Class ; rdfs:label "regulation of behavior" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007610 ] ) ] . obo:GO_0050796 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of insulin." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050796" ; a owl:Class ; rdfs:label "regulation of insulin secretion" ; rdfs:subClassOf obo:GO_0050708, obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030073 ] ) ] . obo:GO_0050801 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:2000021" ; oboInOwl:hasBroadSynonym "ion homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "electrolyte homeostasis", "negative regulation of crystal formation", "regulation of ion homeostasis" ; oboInOwl:id "GO:0050801" ; a owl:Class ; rdfs:label "monoatomic ion homeostasis" ; rdfs:subClassOf obo:GO_0048878 . obo:GO_0050802 obo:IAO_0000115 "The part of the circadian sleep/wake cycle where the organism is asleep." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050802" ; a owl:Class ; rdfs:label "circadian sleep/wake cycle, sleep" ; rdfs:subClassOf obo:GO_0022410, obo:GO_0030431 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0030431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042745 ] ) ] . obo:GO_0050804 obo:IAO_0000115 "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." ; oboInOwl:hasBroadSynonym "modulation of synaptic transmission" ; oboInOwl:hasExactSynonym "regulation of chemical synaptic transmission", "regulation of synaptic transmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050804" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "modulation of chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0099177, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0050805 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." ; oboInOwl:hasExactSynonym "down regulation of synaptic transmission", "down-regulation of synaptic transmission", "downregulation of synaptic transmission" ; oboInOwl:hasNarrowSynonym "inhibition of synaptic transmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050805" ; a owl:Class ; rdfs:label "negative regulation of synaptic transmission" ; rdfs:subClassOf obo:GO_0010648, obo:GO_0023057, obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0050806 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." ; oboInOwl:hasExactSynonym "up regulation of synaptic transmission", "up-regulation of synaptic transmission", "upregulation of synaptic transmission" ; oboInOwl:hasNarrowSynonym "activation of synaptic transmission", "stimulation of synaptic transmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050806" ; a owl:Class ; rdfs:label "positive regulation of synaptic transmission" ; rdfs:subClassOf obo:GO_0010647, obo:GO_0023056, obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0050810 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." ; oboInOwl:hasExactSynonym "regulation of steroid anabolism", "regulation of steroid biosynthesis", "regulation of steroid formation", "regulation of steroid synthesis", "regulation of steroidogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050810" ; a owl:Class ; rdfs:label "regulation of steroid biosynthetic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0046890, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006694 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006694 ] ) ] . obo:GO_0050817 obo:IAO_0000115 "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." ; oboInOwl:hasExactSynonym "clotting" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050817" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "coagulation" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0050818 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." ; oboInOwl:hasExactSynonym "regulation of clotting" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050818" ; a owl:Class ; rdfs:label "regulation of coagulation" ; rdfs:subClassOf obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050817 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050817 ] ) ] . obo:GO_0050819 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." ; oboInOwl:hasExactSynonym "down regulation of coagulation", "down-regulation of coagulation", "downregulation of coagulation", "negative regulation of clotting" ; oboInOwl:hasNarrowSynonym "inhibition of coagulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "anticoagulant activity" ; oboInOwl:id "GO:0050819" ; a owl:Class ; rdfs:label "negative regulation of coagulation" ; rdfs:subClassOf obo:GO_0050818, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050817 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050817 ] ) ] . obo:GO_0050820 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of coagulation." ; oboInOwl:hasExactSynonym "positive regulation of clotting", "up regulation of coagulation", "up-regulation of coagulation", "upregulation of coagulation" ; oboInOwl:hasNarrowSynonym "activation of coagulation", "stimulation of coagulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050820" ; a owl:Class ; rdfs:label "positive regulation of coagulation" ; rdfs:subClassOf obo:GO_0050818, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050817 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050817 ] ) ] . obo:GO_0050863 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of T cell activation." ; oboInOwl:hasExactSynonym "regulation of T lymphocyte activation", "regulation of T-cell activation", "regulation of T-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050863" ; a owl:Class ; rdfs:label "regulation of T cell activation" ; rdfs:subClassOf obo:GO_0051249, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042110 ] ) ] . obo:GO_0050864 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of B cell activation." ; oboInOwl:hasExactSynonym "regulation of B lymphocyte activation", "regulation of B-cell activation", "regulation of B-lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050864" ; a owl:Class ; rdfs:label "regulation of B cell activation" ; rdfs:subClassOf obo:GO_0051249, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042113 ] ) ] . obo:GO_0050865 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050865" ; a owl:Class ; rdfs:label "regulation of cell activation" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001775 ] ) ] . obo:GO_0050866 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." ; oboInOwl:hasExactSynonym "down regulation of cell activation", "down-regulation of cell activation", "downregulation of cell activation" ; oboInOwl:hasNarrowSynonym "inhibition of cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050866" ; a owl:Class ; rdfs:label "negative regulation of cell activation" ; rdfs:subClassOf obo:GO_0048523, obo:GO_0050865, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001775 ] ) ] . obo:GO_0050867 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of activation." ; oboInOwl:hasExactSynonym "up regulation of cell activation", "up-regulation of cell activation", "upregulation of cell activation" ; oboInOwl:hasNarrowSynonym "activation of cell activation", "stimulation of cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050867" ; a owl:Class ; rdfs:label "positive regulation of cell activation" ; rdfs:subClassOf obo:GO_0048522, obo:GO_0050865, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001775 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001775 ] ) ] . obo:GO_0050868 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." ; oboInOwl:hasExactSynonym "down regulation of T cell activation", "down-regulation of T cell activation", "downregulation of T cell activation", "negative regulation of T lymphocyte activation", "negative regulation of T-cell activation", "negative regulation of T-lymphocyte activation" ; oboInOwl:hasNarrowSynonym "inhibition of T cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050868" ; a owl:Class ; rdfs:label "negative regulation of T cell activation" ; rdfs:subClassOf obo:GO_0050863, obo:GO_0051250, obo:GO_1903038, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042110 ] ) ] . obo:GO_0050869 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." ; oboInOwl:hasExactSynonym "down regulation of B cell activation", "down-regulation of B cell activation", "downregulation of B cell activation", "negative regulation of B lymphocyte activation", "negative regulation of B-cell activation", "negative regulation of B-lymphocyte activation" ; oboInOwl:hasNarrowSynonym "inhibition of B cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050869" ; a owl:Class ; rdfs:label "negative regulation of B cell activation" ; rdfs:subClassOf obo:GO_0050864, obo:GO_0051250, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042113 ] ) ] . obo:GO_0050870 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of T cell activation." ; oboInOwl:hasExactSynonym "positive regulation of T lymphocyte activation", "positive regulation of T-cell activation", "positive regulation of T-lymphocyte activation", "up regulation of T cell activation", "up-regulation of T cell activation", "upregulation of T cell activation" ; oboInOwl:hasNarrowSynonym "activation of T cell activation", "stimulation of T cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050870" ; a owl:Class ; rdfs:label "positive regulation of T cell activation" ; rdfs:subClassOf obo:GO_0050863, obo:GO_0051251, obo:GO_1903039, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042110 ] ) ] . obo:GO_0050871 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of B cell activation." ; oboInOwl:hasExactSynonym "positive regulation of B lymphocyte activation", "positive regulation of B-cell activation", "positive regulation of B-lymphocyte activation", "up regulation of B cell activation", "up-regulation of B cell activation", "upregulation of B cell activation" ; oboInOwl:hasNarrowSynonym "activation of B cell activation", "stimulation of B cell activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050871" ; a owl:Class ; rdfs:label "positive regulation of B cell activation" ; rdfs:subClassOf obo:GO_0050864, obo:GO_0051251, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042113 ] ) ] . obo:GO_0050877 obo:IAO_0000115 "A organ system process carried out by any of the organs or tissues of neurological system." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13824"^^xsd:anyURI ; oboInOwl:hasExactSynonym "neurological system process", "neurophysiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "pan-neural process" ; oboInOwl:id "GO:0050877" ; oboInOwl:inSubset go:goslim_agr, go:goslim_chembl, go:goslim_flybase_ribbon, go:goslim_generic, go:goslim_pir ; a owl:Class ; rdfs:label "nervous system process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0050878 obo:IAO_0000115 "Any process that modulates the levels of body fluids." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050878" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "regulation of body fluid levels" ; rdfs:subClassOf obo:GO_0065008 . obo:GO_0050879 obo:IAO_0000115 "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050879" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "multicellular organismal movement" ; rdfs:subClassOf obo:GO_0032501 . obo:GO_0050881 obo:IAO_0000115 "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050881" ; a owl:Class ; rdfs:label "musculoskeletal movement" ; rdfs:subClassOf obo:GO_0050879, obo:GO_0050905 . obo:GO_0050882 obo:IAO_0000115 "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050882" ; a owl:Class ; rdfs:label "voluntary musculoskeletal movement" ; rdfs:subClassOf obo:GO_0050881 . obo:GO_0050884 obo:IAO_0000115 "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." ; oboInOwl:hasExactSynonym "regulation of posture" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050884" ; a owl:Class ; rdfs:label "neuromuscular process controlling posture" ; rdfs:subClassOf obo:GO_0050905, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0050881 ] . obo:GO_0050885 obo:IAO_0000115 "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of balance" ; oboInOwl:id "GO:0050885" ; a owl:Class ; rdfs:label "neuromuscular process controlling balance" ; rdfs:subClassOf obo:GO_0050905, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0050881 ] . obo:GO_0050886 obo:IAO_0000115 "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." ; oboInOwl:hasExactSynonym "endocrine physiological process", "endocrine physiology" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050886" ; oboInOwl:inSubset go:goslim_generic, go:goslim_pir ; a owl:Class ; rdfs:label "endocrine process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0050890 obo:IAO_0000115 "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." ; oboInOwl:hasDbXref "Wikipedia:Cognition" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050890" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "cognition" ; rdfs:subClassOf obo:GO_0050877 . obo:GO_0050891 obo:IAO_0000115 "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24554"^^xsd:anyURI ; oboInOwl:hasExactSynonym "multicellular organismal water homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "body fluid osmoregulation" ; oboInOwl:id "GO:0050891" ; a owl:Class ; rdfs:label "multicellular organismal-level water homeostasis" ; rdfs:subClassOf obo:GO_0050878, obo:GO_0140962 . obo:GO_0050892 obo:IAO_0000115 "Any process in which nutrients are taken up from the contents of the intestine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050892" ; a owl:Class ; rdfs:label "intestinal absorption" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0022600 . obo:GO_0050896 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." ; oboInOwl:hasAlternativeId "GO:0051869" ; oboInOwl:hasExactSynonym "physiological response to stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050896" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "response to stimulus" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0050900 obo:IAO_0000115 "The movement of a leukocyte within or between different tissues and organs of the body." ; oboInOwl:hasExactSynonym "immune cell migration", "immune cell trafficking", "leucocyte migration", "leucocyte trafficking", "leukocyte trafficking" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050900" ; a owl:Class ; rdfs:label "leukocyte migration" ; rdfs:subClassOf obo:GO_0002376, obo:GO_0016477 . obo:GO_0050905 obo:IAO_0000115 "Any process pertaining to the functions of the nervous and muscular systems of an organism." ; oboInOwl:hasExactSynonym "neuromotor process", "neuromuscular physiological process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050905" ; a owl:Class ; rdfs:label "neuromuscular process" ; rdfs:subClassOf obo:GO_0050877 . obo:GO_0050906 obo:IAO_0000115 "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." ; oboInOwl:hasDbXref "Wikipedia:Transduction_(physiology)" ; oboInOwl:hasExactSynonym "sensory detection of stimulus", "sensory perception, sensory transduction of stimulus", "sensory perception, stimulus detection", "sensory transduction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050906" ; a owl:Class ; rdfs:label "detection of stimulus involved in sensory perception" ; rdfs:subClassOf obo:GO_0051606, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007600 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0051606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007600 ] ) ] . obo:GO_0050907 obo:IAO_0000115 "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." ; oboInOwl:hasExactSynonym "sensory detection of chemical stimulus", "sensory detection of chemical stimulus during sensory perception", "sensory perception, sensory detection of chemical stimulus", "sensory perception, sensory transduction of chemical stimulus", "sensory transduction of chemical stimulus", "sensory transduction of chemical stimulus during sensory perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050907" ; a owl:Class ; rdfs:label "detection of chemical stimulus involved in sensory perception" ; rdfs:subClassOf obo:GO_0009593, obo:GO_0050906, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007600 ] ) ] . obo:GO_0050908 obo:IAO_0000115 "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "sensory detection of light during visual perception", "sensory detection of light stimulus during visual perception", "sensory transduction of light during visual perception", "sensory transduction of light stimulus during visual perception", "visual perception, detection of light stimulus", "visual perception, sensory transduction during perception of light", "visual perception, sensory transduction of light stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050908" ; a owl:Class ; rdfs:label "detection of light stimulus involved in visual perception" ; rdfs:subClassOf obo:GO_0009584, obo:GO_0050962, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007601 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009583 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007601 ] ) ] . obo:GO_0050909 obo:IAO_0000115 "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." ; oboInOwl:hasDbXref "Wikipedia:Taste" ; oboInOwl:hasExactSynonym "gustation", "sense of taste", "taste", "taste perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050909" ; a owl:Class ; rdfs:label "sensory perception of taste" ; rdfs:subClassOf obo:GO_0007606 . obo:GO_0050910 obo:IAO_0000115 "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." ; oboInOwl:hasAlternativeId "GO:0009592", "GO:0055128" ; oboInOwl:hasExactSynonym "detection of sound", "hearing, sensory transduction of sound", "perception of sound, detection of mechanical stimulus", "perception of sound, sensory detection of mechanical stimulus", "perception of sound, sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during perception of sound", "sensory transduction of mechanical stimulus during perception of sound", "sensory transduction of sound" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050910" ; a owl:Class ; rdfs:label "detection of mechanical stimulus involved in sensory perception of sound" ; rdfs:subClassOf obo:GO_0050877, obo:GO_0050974, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007605 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007605 ] ) ] . obo:GO_0050911 obo:IAO_0000115 "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "perception of smell, detection of chemical stimulus", "perception of smell, sensory detection of chemical stimulus", "perception of smell, sensory transduction of chemical stimulus", "sensory detection of chemical stimulus during perception of smell", "sensory detection of scent", "sensory detection of smell", "sensory transduction of chemical stimulus during perception of smell", "sensory transduction of scent", "sensory transduction of smell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050911" ; a owl:Class ; rdfs:label "detection of chemical stimulus involved in sensory perception of smell" ; rdfs:subClassOf obo:GO_0050907, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007608 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007608 ] ) ] . obo:GO_0050912 obo:IAO_0000115 "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." ; oboInOwl:hasBroadSynonym "taste perception" ; oboInOwl:hasExactSynonym "perception of taste, detection of chemical stimulus", "perception of taste, sensory detection of chemical stimulus", "perception of taste, sensory transduction of chemical stimulus", "sensory detection of chemical stimulus during perception of taste", "sensory detection of taste", "sensory transduction of chemical stimulus during perception of taste", "sensory transduction of taste" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050912" ; a owl:Class ; rdfs:label "detection of chemical stimulus involved in sensory perception of taste" ; rdfs:subClassOf obo:GO_0050907, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050909 ] ) ] . obo:GO_0050920 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050920" ; a owl:Class ; rdfs:label "regulation of chemotaxis" ; rdfs:subClassOf obo:GO_0032101, obo:GO_0040012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006935 ] ) ] . obo:GO_0050921 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." ; oboInOwl:hasExactSynonym "up regulation of chemotaxis", "up-regulation of chemotaxis", "upregulation of chemotaxis" ; oboInOwl:hasNarrowSynonym "activation of chemotaxis", "stimulation of chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050921" ; a owl:Class ; rdfs:label "positive regulation of chemotaxis" ; rdfs:subClassOf obo:GO_0032103, obo:GO_0040017, obo:GO_0050920, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006935 ] ) ] . obo:GO_0050922 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." ; oboInOwl:hasExactSynonym "down regulation of chemotaxis", "down-regulation of chemotaxis", "downregulation of chemotaxis" ; oboInOwl:hasNarrowSynonym "inhibition of chemotaxis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050922" ; a owl:Class ; rdfs:label "negative regulation of chemotaxis" ; rdfs:subClassOf obo:GO_0032102, obo:GO_0040013, obo:GO_0050920, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006935 ] ) ] . obo:GO_0050953 obo:IAO_0000115 "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050953" ; a owl:Class ; rdfs:label "sensory perception of light stimulus" ; rdfs:subClassOf obo:GO_0007600 . obo:GO_0050954 obo:IAO_0000115 "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." ; oboInOwl:hasExactSynonym "mechanosensory perception", "perception of mechanical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chemi-mechanical coupling" ; oboInOwl:id "GO:0050954" ; a owl:Class ; rdfs:label "sensory perception of mechanical stimulus" ; rdfs:subClassOf obo:GO_0007600 . obo:GO_0050957 obo:IAO_0000115 "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." ; oboInOwl:hasDbXref "Wikipedia:Equilibrioception" ; oboInOwl:hasExactSynonym "sensory perception of orientation with respect to gravity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050957" ; a owl:Class ; rdfs:label "equilibrioception" ; rdfs:subClassOf obo:GO_0007600, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050885 ] . obo:GO_0050962 obo:IAO_0000115 "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." ; oboInOwl:hasExactSynonym "sensory detection of light stimulus", "sensory detection of light stimulus during sensory perception", "sensory perception, sensory detection of light stimulus", "sensory perception, sensory transduction of light stimulus", "sensory transduction of light stimulus", "sensory transduction of light stimulus during sensory perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050962" ; a owl:Class ; rdfs:label "detection of light stimulus involved in sensory perception" ; rdfs:subClassOf obo:GO_0009583, obo:GO_0050906, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050953 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009583 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007600 ] ) ] . obo:GO_0050966 obo:IAO_0000115 "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "perception of pain, detection of mechanical stimulus", "perception of pain, sensory detection of mechanical stimulus", "perception of pain, sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during perception of pain", "sensory transduction of mechanical stimulus during perception of pain" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "mechanical nociception" ; oboInOwl:id "GO:0050966" ; a owl:Class ; rdfs:label "detection of mechanical stimulus involved in sensory perception of pain" ; rdfs:subClassOf obo:GO_0050974, obo:GO_0062149 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_0050968 obo:IAO_0000115 "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "perception of pain, detection of chemical stimulus", "perception of pain, sensory detection of chemical stimulus", "perception of pain, sensory transduction of chemical stimulus", "sensory detection of chemical stimulus during perception of pain", "sensory transduction of chemical stimulus during perception of pain" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chemical nociception" ; oboInOwl:id "GO:0050968" ; a owl:Class ; rdfs:label "detection of chemical stimulus involved in sensory perception of pain" ; rdfs:subClassOf obo:GO_0050907, obo:GO_0062149 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_0050973 obo:IAO_0000115 "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." ; oboInOwl:hasExactSynonym "equilibrioception, detection of mechanical stimulus", "equilibrioception, sensory detection of mechanical stimulus", "equilibrioception, sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during equilibrioception", "sensory transduction of mechanical stimulus during equilibrioception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050973" ; a owl:Class ; rdfs:label "detection of mechanical stimulus involved in equilibrioception" ; rdfs:subClassOf obo:GO_0050974, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ) ] . obo:GO_0050974 obo:IAO_0000115 "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." ; oboInOwl:hasExactSynonym "sensory detection of mechanical stimulus", "sensory detection of mechanical stimulus during sensory perception", "sensory perception, sensory detection of mechanical stimulus", "sensory perception, sensory transduction of mechanical stimulus", "sensory transduction of mechanical stimulus", "sensory transduction of mechanical stimulus during sensory perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050974" ; a owl:Class ; rdfs:label "detection of mechanical stimulus involved in sensory perception" ; rdfs:subClassOf obo:GO_0050906, obo:GO_0050982, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050954 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007600 ] ) ] . obo:GO_0050975 obo:IAO_0000115 "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." ; oboInOwl:hasDbXref "Wikipedia:Touch" ; oboInOwl:hasExactSynonym "perception of touch", "tactile sense", "taction", "tactition" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050975" ; a owl:Class ; rdfs:label "sensory perception of touch" ; rdfs:subClassOf obo:GO_0050954 . obo:GO_0050976 obo:IAO_0000115 "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." ; oboInOwl:hasExactSynonym "perception of touch, detection of mechanical stimulus", "perception of touch, sensory detection of mechanical stimulus", "perception of touch, sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during perception of touch", "sensory transduction of mechanical stimulus during perception of touch", "tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050976" ; a owl:Class ; rdfs:label "detection of mechanical stimulus involved in sensory perception of touch" ; rdfs:subClassOf obo:GO_0050974, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050975 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050975 ] ) ] . obo:GO_0050982 obo:IAO_0000115 "The series of events by which a mechanical stimulus is received and converted into a molecular signal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0050982" ; a owl:Class ; rdfs:label "detection of mechanical stimulus" ; rdfs:subClassOf obo:GO_0009581, obo:GO_0009582, obo:GO_0009612 . obo:GO_0051046 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051046" ; a owl:Class ; rdfs:label "regulation of secretion" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046903 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046903 ] ) ] . obo:GO_0051047 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." ; oboInOwl:hasExactSynonym "up regulation of secretion", "up-regulation of secretion", "upregulation of secretion" ; oboInOwl:hasNarrowSynonym "activation of secretion", "stimulation of secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051047" ; a owl:Class ; rdfs:label "positive regulation of secretion" ; rdfs:subClassOf obo:GO_0051046, obo:GO_0051050, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046903 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046903 ] ) ] . obo:GO_0051048 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." ; oboInOwl:hasExactSynonym "down regulation of secretion", "down-regulation of secretion", "downregulation of secretion" ; oboInOwl:hasNarrowSynonym "inhibition of secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051048" ; a owl:Class ; rdfs:label "negative regulation of secretion" ; rdfs:subClassOf obo:GO_0051046, obo:GO_0051051, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046903 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046903 ] ) ] . obo:GO_0051049 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051049" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of transport" ; rdfs:subClassOf obo:GO_0032879, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006810 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006810 ] ) ] . obo:GO_0051050 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of transport", "up-regulation of transport", "upregulation of transport" ; oboInOwl:hasNarrowSynonym "activation of transport", "stimulation of transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051050" ; a owl:Class ; rdfs:label "positive regulation of transport" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006810 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006810 ] ) ] . obo:GO_0051051 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of transport", "down-regulation of transport", "downregulation of transport" ; oboInOwl:hasNarrowSynonym "inhibition of transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051051" ; a owl:Class ; rdfs:label "negative regulation of transport" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006810 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006810 ] ) ] . obo:GO_0051052 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." ; oboInOwl:hasExactSynonym "regulation of DNA metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051052" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of DNA metabolic process" ; rdfs:subClassOf obo:GO_0019219, obo:GO_0060255, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006259 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006259 ] ) ] . obo:GO_0051053 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." ; oboInOwl:hasExactSynonym "down regulation of DNA metabolic process", "down-regulation of DNA metabolic process", "downregulation of DNA metabolic process", "negative regulation of DNA metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of DNA metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051053" ; a owl:Class ; rdfs:label "negative regulation of DNA metabolic process" ; rdfs:subClassOf obo:GO_0010605, obo:GO_0045934, obo:GO_0051052, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006259 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006259 ] ) ] . obo:GO_0051054 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." ; oboInOwl:hasExactSynonym "positive regulation of DNA metabolism", "up regulation of DNA metabolic process", "up-regulation of DNA metabolic process", "upregulation of DNA metabolic process" ; oboInOwl:hasNarrowSynonym "activation of DNA metabolic process", "stimulation of DNA metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051054" ; a owl:Class ; rdfs:label "positive regulation of DNA metabolic process" ; rdfs:subClassOf obo:GO_0010604, obo:GO_0045935, obo:GO_0051052, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006259 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006259 ] ) ] . obo:GO_0051055 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." ; oboInOwl:hasExactSynonym "down regulation of lipid biosynthetic process", "down-regulation of lipid biosynthetic process", "downregulation of lipid biosynthetic process", "negative regulation of lipid anabolism", "negative regulation of lipid biosynthesis", "negative regulation of lipid formation", "negative regulation of lipid synthesis", "negative regulation of lipogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of lipid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051055" ; a owl:Class ; rdfs:label "negative regulation of lipid biosynthetic process" ; rdfs:subClassOf obo:GO_0009890, obo:GO_0045833, obo:GO_0046890, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008610 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008610 ] ) ] . obo:GO_0051093 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." ; oboInOwl:hasExactSynonym "down regulation of developmental process", "down-regulation of developmental process", "downregulation of developmental process" ; oboInOwl:hasNarrowSynonym "inhibition of developmental process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051093" ; a owl:Class ; rdfs:label "negative regulation of developmental process" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032502 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032502 ] ) ] . obo:GO_0051094 obo:IAO_0000115 "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." ; oboInOwl:hasExactSynonym "up regulation of developmental process", "up-regulation of developmental process", "upregulation of developmental process" ; oboInOwl:hasNarrowSynonym "activation of developmental process", "stimulation of developmental process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051094" ; a owl:Class ; rdfs:label "positive regulation of developmental process" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032502 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032502 ] ) ] . obo:GO_0051128 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." ; oboInOwl:hasExactSynonym "regulation of cellular component organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cell organisation", "regulation of cell organization", "regulation of cellular component organization and biogenesis" ; oboInOwl:id "GO:0051128" ; a owl:Class ; rdfs:label "regulation of cellular component organization" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016043 ] ) ] . obo:GO_0051129 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." ; oboInOwl:hasExactSynonym "down regulation of cell organization", "down-regulation of cell organization", "downregulation of cell organization" ; oboInOwl:hasNarrowSynonym "inhibition of cell organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cell organisation", "negative regulation of cellular component organization and biogenesis" ; oboInOwl:id "GO:0051129" ; a owl:Class ; rdfs:label "negative regulation of cellular component organization" ; rdfs:subClassOf obo:GO_0048523, obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016043 ] ) ] . obo:GO_0051130 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." ; oboInOwl:hasExactSynonym "positive regulation of cell organisation", "up regulation of cell organization", "up-regulation of cell organization", "upregulation of cell organization" ; oboInOwl:hasNarrowSynonym "activation of cell organization", "stimulation of cell organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cellular component organization and biogenesis" ; oboInOwl:id "GO:0051130" ; a owl:Class ; rdfs:label "positive regulation of cellular component organization" ; rdfs:subClassOf obo:GO_0048522, obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016043 ] ) ] . obo:GO_0051171 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." ; oboInOwl:hasExactSynonym "regulation of nitrogen metabolic process", "regulation of nitrogen metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051171" ; a owl:Class ; rdfs:label "regulation of nitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006807 ] ) ] . obo:GO_0051172 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." ; oboInOwl:hasExactSynonym "down regulation of nitrogen metabolic process", "down-regulation of nitrogen metabolic process", "downregulation of nitrogen metabolic process", "negative regulation of nitrogen metabolic process", "negative regulation of nitrogen metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of nitrogen metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051172" ; a owl:Class ; rdfs:label "negative regulation of nitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006807 ] ) ] . obo:GO_0051173 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." ; oboInOwl:hasExactSynonym "positive regulation of nitrogen metabolic process", "positive regulation of nitrogen metabolism", "up regulation of nitrogen metabolic process", "up-regulation of nitrogen metabolic process", "upregulation of nitrogen metabolic process" ; oboInOwl:hasNarrowSynonym "activation of nitrogen metabolic process", "stimulation of nitrogen metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051173" ; a owl:Class ; rdfs:label "positive regulation of nitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006807 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006807 ] ) ] . obo:GO_0051174 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." ; oboInOwl:hasExactSynonym "regulation of phosphorus metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051174" ; a owl:Class ; rdfs:label "regulation of phosphorus metabolic process" ; rdfs:subClassOf obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006793 ] ) ] . obo:GO_0051175 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." ; oboInOwl:hasExactSynonym "down regulation of sulfur metabolic process", "down-regulation of sulfur metabolic process", "downregulation of sulfur metabolic process", "negative regulation of sulfur metabolism", "negative regulation of sulphur metabolic process", "negative regulation of sulphur metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of sulfur metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051175" ; a owl:Class ; rdfs:label "negative regulation of sulfur metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0042762, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006790 ] ) ] . obo:GO_0051176 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." ; oboInOwl:hasExactSynonym "positive regulation of sulfur metabolism", "positive regulation of sulphur metabolic process", "positive regulation of sulphur metabolism", "up regulation of sulfur metabolic process", "up-regulation of sulfur metabolic process", "upregulation of sulfur metabolic process" ; oboInOwl:hasNarrowSynonym "activation of sulfur metabolic process", "stimulation of sulfur metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051176" ; a owl:Class ; rdfs:label "positive regulation of sulfur metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0042762, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006790 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006790 ] ) ] . obo:GO_0051179 obo:IAO_0000115 "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-18T13:51:04Z" ; oboInOwl:hasAlternativeId "GO:1902578" ; oboInOwl:hasExactSynonym "establishment and maintenance of localization", "establishment and maintenance of position", "localisation" ; oboInOwl:hasNarrowSynonym "establishment and maintenance of cellular component location", "establishment and maintenance of substance location", "establishment and maintenance of substrate location" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single organism localization", "single-organism localization" ; oboInOwl:id "GO:0051179" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "localization" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0051216 obo:IAO_0000115 "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." ; oboInOwl:hasDbXref "Wikipedia:Chondrogenesis" ; oboInOwl:hasExactSynonym "cartilage biogenesis", "cartilage biosynthesis", "cartilage element development", "cartilage formation", "cartilage organ development", "chondrogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051216" ; a owl:Class ; rdfs:label "cartilage development" ; rdfs:subClassOf obo:GO_0048513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001501 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0061448 ] . obo:GO_0051222 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of protein transport", "up-regulation of protein transport", "upregulation of protein transport" ; oboInOwl:hasNarrowSynonym "activation of protein transport", "stimulation of protein transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051222" ; a owl:Class ; rdfs:label "positive regulation of protein transport" ; rdfs:subClassOf obo:GO_0051050, obo:GO_0051223, obo:GO_1904951, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015031 ] ) ] . obo:GO_0051223 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051223" ; a owl:Class ; rdfs:label "regulation of protein transport" ; rdfs:subClassOf obo:GO_0051049, obo:GO_0070201, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015031 ] ) ] . obo:GO_0051224 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of protein transport", "down-regulation of protein transport", "downregulation of protein transport" ; oboInOwl:hasNarrowSynonym "inhibition of protein transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051224" ; a owl:Class ; rdfs:label "negative regulation of protein transport" ; rdfs:subClassOf obo:GO_0051051, obo:GO_0051223, obo:GO_1904950, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015031 ] ) ] . obo:GO_0051234 obo:IAO_0000115 "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." ; oboInOwl:hasExactSynonym "establishment of localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051234" ; oboInOwl:inSubset go:goslim_agr, go:goslim_flybase_ribbon, go:goslim_mouse, go:goslim_pir ; a owl:Class ; rdfs:label "establishment of localization" ; rdfs:subClassOf obo:GO_0051179 . obo:GO_0051239 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051239" ; a owl:Class ; rdfs:label "regulation of multicellular organismal process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032501 ] ) ] . obo:GO_0051240 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." ; oboInOwl:hasExactSynonym "up regulation of multicellular organismal process", "up-regulation of multicellular organismal process", "upregulation of multicellular organismal process" ; oboInOwl:hasNarrowSynonym "activation of multicellular organismal process", "stimulation of multicellular organismal process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051240" ; a owl:Class ; rdfs:label "positive regulation of multicellular organismal process" ; rdfs:subClassOf obo:GO_0048518, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032501 ] ) ] . obo:GO_0051241 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." ; oboInOwl:hasExactSynonym "down regulation of multicellular organismal process", "down-regulation of multicellular organismal process", "downregulation of multicellular organismal process" ; oboInOwl:hasNarrowSynonym "inhibition of multicellular organismal process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051241" ; a owl:Class ; rdfs:label "negative regulation of multicellular organismal process" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032501 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032501 ] ) ] . obo:GO_0051246 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0032268" ; oboInOwl:hasExactSynonym "regulation of protein metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cellular protein metabolic process", "regulation of cellular protein metabolism" ; oboInOwl:id "GO:0051246" ; a owl:Class ; rdfs:label "regulation of protein metabolic process" ; rdfs:subClassOf obo:GO_0051171, obo:GO_0060255, obo:GO_0080090, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019538 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019538 ] ) ] . obo:GO_0051247 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0032270" ; oboInOwl:hasExactSynonym "positive regulation of cellular protein metabolic process", "positive regulation of cellular protein metabolism", "positive regulation of protein metabolism", "up regulation of cellular protein metabolic process", "up regulation of protein metabolic process", "up-regulation of cellular protein metabolic process", "up-regulation of protein metabolic process", "upregulation of cellular protein metabolic process", "upregulation of protein metabolic process" ; oboInOwl:hasNarrowSynonym "activation of cellular protein metabolic process", "activation of protein metabolic process", "stimulation of cellular protein metabolic process", "stimulation of protein metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051247" ; a owl:Class ; rdfs:label "positive regulation of protein metabolic process" ; rdfs:subClassOf obo:GO_0010604, obo:GO_0051173, obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019538 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019538 ] ) ] . obo:GO_0051248 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0032269" ; oboInOwl:hasExactSynonym "down regulation of cellular protein metabolic process", "down regulation of protein metabolic process", "down-regulation of cellular protein metabolic process", "down-regulation of protein metabolic process", "downregulation of cellular protein metabolic process", "downregulation of protein metabolic process", "negative regulation of cellular protein metabolic process", "negative regulation of cellular protein metabolism", "negative regulation of protein metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of cellular protein metabolic process", "inhibition of protein metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051248" ; a owl:Class ; rdfs:label "negative regulation of protein metabolic process" ; rdfs:subClassOf obo:GO_0010605, obo:GO_0051172, obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019538 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019538 ] ) ] . obo:GO_0051249 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lymphocyte activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051249" ; a owl:Class ; rdfs:label "regulation of lymphocyte activation" ; rdfs:subClassOf obo:GO_0002694, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046649 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0046649 ] ) ] . obo:GO_0051250 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." ; oboInOwl:hasExactSynonym "down regulation of lymphocyte activation", "down-regulation of lymphocyte activation", "downregulation of lymphocyte activation" ; oboInOwl:hasNarrowSynonym "inhibition of lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051250" ; a owl:Class ; rdfs:label "negative regulation of lymphocyte activation" ; rdfs:subClassOf obo:GO_0002695, obo:GO_0051249, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046649 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046649 ] ) ] . obo:GO_0051251 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." ; oboInOwl:hasExactSynonym "up regulation of lymphocyte activation", "up-regulation of lymphocyte activation", "upregulation of lymphocyte activation" ; oboInOwl:hasNarrowSynonym "activation of lymphocyte activation", "stimulation of lymphocyte activation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051251" ; a owl:Class ; rdfs:label "positive regulation of lymphocyte activation" ; rdfs:subClassOf obo:GO_0002696, obo:GO_0051249, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046649 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0046649 ] ) ] . obo:GO_0051276 obo:IAO_0000115 "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22811"^^xsd:anyURI, "https://github.com/geneontology/go-ontology/issues/4585"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0006323", "GO:0007001", "GO:0051277" ; oboInOwl:hasExactSynonym "DNA condensation", "chromosome organisation" ; oboInOwl:hasNarrowSynonym "DNA packaging" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "chromosome organization and biogenesis", "maintenance of genome integrity", "nuclear genome maintenance" ; oboInOwl:id "GO:0051276" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_pir ; a owl:Class ; rdfs:label "chromosome organization" ; rdfs:subClassOf obo:GO_0006996 . obo:GO_0051301 obo:IAO_0000115 "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." ; oboInOwl:hasDbXref "Wikipedia:Cell_division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051301" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_pir ; a owl:Class ; rdfs:comment "Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division." ; rdfs:label "cell division" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0051302 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051302" ; a owl:Class ; rdfs:label "regulation of cell division" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051301 ] ) ] . obo:GO_0051319 obo:IAO_0000115 "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." ; oboInOwl:hasDbXref "Wikipedia:G2_phase" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051319" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "G2 phase" ; rdfs:subClassOf obo:GO_0022403, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051325 ] . obo:GO_0051321 obo:IAO_0000115 "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24599"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0007126" ; oboInOwl:hasDbXref "Wikipedia:Meiosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "meiosis" ; oboInOwl:id "GO:0051321" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_yeast ; a owl:Class ; rdfs:comment "Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ; rdfs:label "meiotic cell cycle" ; rdfs:subClassOf obo:GO_0007049, obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019953 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0140013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0140013 ] ) ] . obo:GO_0051325 obo:IAO_0000115 "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." ; oboInOwl:hasBroadSynonym "resting phase" ; oboInOwl:hasDbXref "Wikipedia:Interphase" ; oboInOwl:hasExactSynonym "karyostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051325" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ; rdfs:label "interphase" ; rdfs:subClassOf obo:GO_0022403 . obo:GO_0051336 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." ; oboInOwl:hasExactSynonym "hydrolase regulator" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051336" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of hydrolase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016787 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016787 ] ) ] . obo:GO_0051338 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." ; oboInOwl:hasExactSynonym "transferase regulator" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051338" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ; rdfs:label "regulation of transferase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016740 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016740 ] ) ] . obo:GO_0051339 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." ; oboInOwl:hasExactSynonym "lyase regulator" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051339" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of lyase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016829 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016829 ] ) ] . obo:GO_0051340 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." ; oboInOwl:hasExactSynonym "ligase regulator" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051340" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of ligase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016874 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016874 ] ) ] . obo:GO_0051341 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." ; oboInOwl:hasExactSynonym "oxidoreductase regulator" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051341" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "regulation of oxidoreductase activity" ; rdfs:subClassOf obo:GO_0050790, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016491 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016491 ] ) ] . obo:GO_0051345 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." ; oboInOwl:hasExactSynonym "hydrolase activator", "up regulation of hydrolase activity", "up-regulation of hydrolase activity", "upregulation of hydrolase activity" ; oboInOwl:hasNarrowSynonym "activation of hydrolase activity", "stimulation of hydrolase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051345" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of hydrolase activity" ; rdfs:subClassOf obo:GO_0043085, obo:GO_0051336, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016787 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016787 ] ) ] . obo:GO_0051346 obo:IAO_0000115 "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." ; oboInOwl:hasExactSynonym "down regulation of hydrolase activity", "down-regulation of hydrolase activity", "downregulation of hydrolase activity", "hydrolase inhibitor" ; oboInOwl:hasNarrowSynonym "inhibition of hydrolase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051346" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of hydrolase activity" ; rdfs:subClassOf obo:GO_0043086, obo:GO_0051336, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016787 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016787 ] ) ] . obo:GO_0051347 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." ; oboInOwl:hasExactSynonym "transferase activator", "up regulation of transferase activity", "up-regulation of transferase activity", "upregulation of transferase activity" ; oboInOwl:hasNarrowSynonym "activation of transferase activity", "stimulation of transferase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051347" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ; rdfs:label "positive regulation of transferase activity" ; rdfs:subClassOf obo:GO_0043085, obo:GO_0051338, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016740 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016740 ] ) ] . obo:GO_0051348 obo:IAO_0000115 "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." ; oboInOwl:hasExactSynonym "down regulation of transferase activity", "down-regulation of transferase activity", "downregulation of transferase activity", "transferase inhibitor" ; oboInOwl:hasNarrowSynonym "inhibition of transferase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051348" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ; rdfs:label "negative regulation of transferase activity" ; rdfs:subClassOf obo:GO_0043086, obo:GO_0051338, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016740 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016740 ] ) ] . obo:GO_0051349 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." ; oboInOwl:hasExactSynonym "lyase activator", "up regulation of lyase activity", "up-regulation of lyase activity", "upregulation of lyase activity" ; oboInOwl:hasNarrowSynonym "activation of lyase activity", "stimulation of lyase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051349" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of lyase activity" ; rdfs:subClassOf obo:GO_0043085, obo:GO_0051339, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016829 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016829 ] ) ] . obo:GO_0051350 obo:IAO_0000115 "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." ; oboInOwl:hasExactSynonym "down regulation of lyase activity", "down-regulation of lyase activity", "downregulation of lyase activity", "lyase inhibitor" ; oboInOwl:hasNarrowSynonym "inhibition of lyase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051350" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of lyase activity" ; rdfs:subClassOf obo:GO_0043086, obo:GO_0051339, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016829 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016829 ] ) ] . obo:GO_0051351 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." ; oboInOwl:hasExactSynonym "ligase activator", "up regulation of ligase activity", "up-regulation of ligase activity", "upregulation of ligase activity" ; oboInOwl:hasNarrowSynonym "activation of ligase activity", "stimulation of ligase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051351" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of ligase activity" ; rdfs:subClassOf obo:GO_0043085, obo:GO_0051340, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016874 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016874 ] ) ] . obo:GO_0051352 obo:IAO_0000115 "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." ; oboInOwl:hasExactSynonym "down regulation of ligase activity", "down-regulation of ligase activity", "downregulation of ligase activity", "ligase inhibitor" ; oboInOwl:hasNarrowSynonym "inhibition of ligase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051352" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of ligase activity" ; rdfs:subClassOf obo:GO_0043086, obo:GO_0051340, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016874 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016874 ] ) ] . obo:GO_0051353 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." ; oboInOwl:hasAlternativeId "GO:0009391" ; oboInOwl:hasExactSynonym "oxidoreductase activator", "up regulation of oxidoreductase activity", "up-regulation of oxidoreductase activity", "upregulation of oxidoreductase activity" ; oboInOwl:hasNarrowSynonym "activation of oxidoreductase activity", "ribonucleotide reductase activating enzyme activity", "stimulation of oxidoreductase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051353" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of oxidoreductase activity" ; rdfs:subClassOf obo:GO_0043085, obo:GO_0051341, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016491 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0016491 ] ) ] . obo:GO_0051354 obo:IAO_0000115 "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." ; oboInOwl:hasExactSynonym "down regulation of oxidoreductase activity", "down-regulation of oxidoreductase activity", "downregulation of oxidoreductase activity", "oxidoreductase inhibitor" ; oboInOwl:hasNarrowSynonym "inhibition of oxidoreductase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051354" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of oxidoreductase activity" ; rdfs:subClassOf obo:GO_0043086, obo:GO_0051341, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016491 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0016491 ] ) ] . obo:GO_0051355 obo:IAO_0000115 "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." ; oboInOwl:hasExactSynonym "equilibrioception by proprioception", "perception of orientation with respect to gravity by proprioception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "proprioception during equilibrioception" ; oboInOwl:id "GO:0051355" ; a owl:Class ; rdfs:label "proprioception involved in equilibrioception" ; rdfs:subClassOf obo:GO_0019230, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0019230 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ) ] . obo:GO_0051356 obo:IAO_0000115 "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." ; oboInOwl:hasExactSynonym "perception of orientation with respect to gravity by visual perception" ; oboInOwl:hasNarrowSynonym "equilibrioception by visual perception" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "visual perception during equilibrioception" ; oboInOwl:id "GO:0051356" ; a owl:Class ; rdfs:label "visual perception involved in equilibrioception" ; rdfs:subClassOf obo:GO_0007601, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007601 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050957 ] ) ] . obo:GO_0051445 obo:IAO_0000115 "Any process that modulates the rate or extent of progression through the meiotic cell cycle." ; oboInOwl:hasExactSynonym "meiotic cell cycle modulation", "meiotic cell cycle regulation", "modulation of meiotic cell cycle progression", "regulation of meiotic cell cycle progression", "regulation of progression through meiotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "meiotic cell cycle regulator" ; oboInOwl:id "GO:0051445" ; a owl:Class ; rdfs:label "regulation of meiotic cell cycle" ; rdfs:subClassOf obo:GO_0051726, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0051446 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." ; oboInOwl:hasExactSynonym "positive regulation of meiotic cell cycle progression", "positive regulation of progression through meiotic cell cycle", "up regulation of progression through meiotic cell cycle", "up-regulation of progression through meiotic cell cycle", "upregulation of progression through meiotic cell cycle" ; oboInOwl:hasNarrowSynonym "activation of progression through meiotic cell cycle", "stimulation of progression through meiotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051446" ; a owl:Class ; rdfs:label "positive regulation of meiotic cell cycle" ; rdfs:subClassOf obo:GO_0045787, obo:GO_0051445, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0051447 obo:IAO_0000115 "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." ; oboInOwl:hasExactSynonym "down regulation of progression through meiotic cell cycle", "down-regulation of progression through meiotic cell cycle", "downregulation of progression through meiotic cell cycle", "negative regulation of meiotic cell cycle progression", "negative regulation of progression through meiotic cell cycle" ; oboInOwl:hasNarrowSynonym "inhibition of progression through meiotic cell cycle" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051447" ; a owl:Class ; rdfs:label "negative regulation of meiotic cell cycle" ; rdfs:subClassOf obo:GO_0045786, obo:GO_0051445, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0051458 obo:IAO_0000115 "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." ; oboInOwl:hasExactSynonym "ACTH secretion", "adrenocorticotropic hormone secretion", "adrenotropic hormone secretion", "adrenotropin secretion", "corticotropic hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "adrenocorticotropin secretion" ; oboInOwl:id "GO:0051458" ; a owl:Class ; rdfs:label "corticotropin secretion" ; rdfs:subClassOf obo:GO_0030072, obo:GO_0060986 . obo:GO_0051459 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." ; oboInOwl:hasExactSynonym "regulation of ACTH secretion", "regulation of adrenocorticotropic hormone secretion", "regulation of adrenocorticotropin secretion", "regulation of adrenotropin hormone secretion", "regulation of adrenotropin secretion", "regulation of corticotropic hormone secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051459" ; a owl:Class ; rdfs:label "regulation of corticotropin secretion" ; rdfs:subClassOf obo:GO_0044060, obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051458 ] ) ] . obo:GO_0051460 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." ; oboInOwl:hasExactSynonym "down regulation of adrenocorticotropin secretion", "down-regulation of adrenocorticotropin secretion", "downregulation of adrenocorticotropin secretion", "negative regulation of ACTH secretion", "negative regulation of adrenocorticotropic hormone secretion", "negative regulation of adrenocorticotropin secretion", "negative regulation of adrenotropic hormone secretion", "negative regulation of adrenotropin secretion", "negative regulation of corticotropic hormone secretion" ; oboInOwl:hasNarrowSynonym "inhibition of adrenocorticotropin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051460" ; a owl:Class ; rdfs:label "negative regulation of corticotropin secretion" ; rdfs:subClassOf obo:GO_0051241, obo:GO_0051459, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051458 ] ) ] . obo:GO_0051461 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." ; oboInOwl:hasExactSynonym "positive regulation of ACTH secretion", "positive regulation of adrenocorticotropic hormone secretion", "positive regulation of adrenocorticotropin secretion", "positive regulation of adrenotropic hormone secretion", "positive regulation of adrenotropin secretion", "positive regulation of corticotropic hormone secretion", "up regulation of adrenocorticotropin secretion", "up-regulation of adrenocorticotropin secretion", "upregulation of adrenocorticotropin secretion" ; oboInOwl:hasNarrowSynonym "activation of adrenocorticotropin secretion", "stimulation of adrenocorticotropin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051461" ; a owl:Class ; rdfs:label "positive regulation of corticotropin secretion" ; rdfs:subClassOf obo:GO_0051240, obo:GO_0051459, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051458 ] ) ] . obo:GO_0051493 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." ; oboInOwl:hasExactSynonym "regulation of cytoskeleton organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cytoskeleton organization and biogenesis" ; oboInOwl:id "GO:0051493" ; a owl:Class ; rdfs:label "regulation of cytoskeleton organization" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007010 ] ) ] . obo:GO_0051494 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." ; oboInOwl:hasExactSynonym "down regulation of cytoskeleton organization", "down-regulation of cytoskeleton organization", "downregulation of cytoskeleton organization", "negative regulation of cytoskeleton organisation" ; oboInOwl:hasNarrowSynonym "inhibition of cytoskeleton organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cytoskeleton organization and biogenesis" ; oboInOwl:id "GO:0051494" ; a owl:Class ; rdfs:label "negative regulation of cytoskeleton organization" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0051493, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007010 ] ) ] . obo:GO_0051495 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." ; oboInOwl:hasExactSynonym "positive regulation of cytoskeleton organisation", "up regulation of cytoskeleton organization", "up-regulation of cytoskeleton organization", "upregulation of cytoskeleton organization" ; oboInOwl:hasNarrowSynonym "activation of cytoskeleton organization", "stimulation of cytoskeleton organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cytoskeleton organization and biogenesis" ; oboInOwl:id "GO:0051495" ; a owl:Class ; rdfs:label "positive regulation of cytoskeleton organization" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0051493, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007010 ] ) ] . obo:GO_0051560 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." ; oboInOwl:hasExactSynonym "calcium ion homeostasis in mitochondria", "calcium ion homeostasis in mitochondrion", "mitochondrial calcium ion concentration regulation", "regulation of calcium ion concentration in mitochondria", "regulation of calcium ion concentration in mitochondrion", "regulation of mitochondrial calcium ion concentration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051560" ; a owl:Class ; rdfs:label "mitochondrial calcium ion homeostasis" ; rdfs:subClassOf obo:GO_0006874, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0055074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0051588 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051588" ; a owl:Class ; rdfs:label "regulation of neurotransmitter transport" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006836 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006836 ] ) ] . obo:GO_0051589 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of neurotransmitter transport", "down-regulation of neurotransmitter transport", "downregulation of neurotransmitter transport" ; oboInOwl:hasNarrowSynonym "inhibition of neurotransmitter transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051589" ; a owl:Class ; rdfs:label "negative regulation of neurotransmitter transport" ; rdfs:subClassOf obo:GO_0051051, obo:GO_0051588, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006836 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006836 ] ) ] . obo:GO_0051590 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of neurotransmitter transport", "up-regulation of neurotransmitter transport", "upregulation of neurotransmitter transport" ; oboInOwl:hasNarrowSynonym "activation of neurotransmitter transport", "stimulation of neurotransmitter transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051590" ; a owl:Class ; rdfs:label "positive regulation of neurotransmitter transport" ; rdfs:subClassOf obo:GO_0051050, obo:GO_0051588, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006836 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006836 ] ) ] . obo:GO_0051596 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." ; oboInOwl:hasDbXref "MetaCyc:METHGLYUT-PWY", "MetaCyc:Methylglyoxal-Detoxification" ; oboInOwl:hasExactSynonym "methylglyoxal breakdown", "methylglyoxal catabolism", "methylglyoxal degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051596" ; a owl:Class ; rdfs:label "methylglyoxal catabolic process" ; rdfs:subClassOf obo:GO_0009438, obo:GO_0042182, obo:GO_0046185 . obo:GO_0051604 obo:IAO_0000115 "Any process leading to the attainment of the full functional capacity of a protein." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051604" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "protein maturation" ; rdfs:subClassOf obo:GO_0019538, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0010467 ] . obo:GO_0051606 obo:IAO_0000115 "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." ; oboInOwl:hasExactSynonym "stimulus detection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "perception of stimulus", "stimulus sensing" ; oboInOwl:id "GO:0051606" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "detection of stimulus" ; rdfs:subClassOf obo:GO_0050896 . obo:GO_0051607 obo:IAO_0000115 "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." ; oboInOwl:hasExactSynonym "antiviral response", "defence response to virus", "defense response to viruses" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051607" ; a owl:Class ; rdfs:label "defense response to virus" ; rdfs:subClassOf obo:GO_0009615, obo:GO_0140546 . obo:GO_0051608 obo:IAO_0000115 "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051608" ; a owl:Class ; rdfs:label "histamine transport" ; rdfs:subClassOf obo:GO_0071702, obo:GO_0071705 . obo:GO_0051640 obo:IAO_0000115 "Any process in which an organelle is transported to, and/or maintained in, a specific location." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19809"^^xsd:anyURI ; oboInOwl:hasExactSynonym "establishment and maintenance of organelle localization", "organelle localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051640" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "organelle localization" ; rdfs:subClassOf obo:GO_0051179 . obo:GO_0051641 obo:IAO_0000115 "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-12-18T14:04:32Z" ; oboInOwl:hasAlternativeId "GO:1902580" ; oboInOwl:hasExactSynonym "cellular localisation", "establishment and maintenance of cellular localization", "establishment and maintenance of localization in cell or cell membrane", "single organism cellular localization" ; oboInOwl:hasNarrowSynonym "intracellular localization", "localization within cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism cellular localization" ; oboInOwl:id "GO:0051641" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular localization" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0051179 . obo:GO_0051648 obo:IAO_0000115 "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." ; oboInOwl:hasExactSynonym "cytoplasmic vesicle localization", "establishment and maintenance of vesicle localization", "vesicle localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051648" ; a owl:Class ; rdfs:label "vesicle localization" ; rdfs:subClassOf obo:GO_0051640 . obo:GO_0051649 obo:IAO_0000115 "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." ; oboInOwl:hasExactSynonym "establishment of localisation in cell" ; oboInOwl:hasNarrowSynonym "establishment of intracellular localization", "establishment of localization within cell", "positioning within cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "establishment of cellular localization" ; oboInOwl:id "GO:0051649" ; a owl:Class ; rdfs:label "establishment of localization in cell" ; rdfs:subClassOf obo:GO_0051234, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051641 ] . obo:GO_0051650 obo:IAO_0000115 "The directed movement of a vesicle to a specific location." ; oboInOwl:hasExactSynonym "establishment of vesicle localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051650" ; a owl:Class ; rdfs:label "establishment of vesicle localization" ; rdfs:subClassOf obo:GO_0051648, obo:GO_0051649, obo:GO_0051656 . obo:GO_0051656 obo:IAO_0000115 "The directed movement of an organelle to a specific location." ; oboInOwl:hasExactSynonym "establishment of organelle localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051656" ; a owl:Class ; rdfs:label "establishment of organelle localization" ; rdfs:subClassOf obo:GO_0051234, obo:GO_0051640 . obo:GO_0051702 obo:IAO_0000115 "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20191"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "interaction with symbiont" ; oboInOwl:id "GO:0051702" ; a owl:Class ; rdfs:label "biological process involved in interaction with symbiont" ; rdfs:subClassOf obo:GO_0044403 . obo:GO_0051703 obo:IAO_0000115 "Any process in which an organism has an effect on an organism of the same species." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20191"^^xsd:anyURI ; oboInOwl:hasExactSynonym "intraspecies interaction between organisms", "intraspecies interaction with other organisms" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051703" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir ; a owl:Class ; rdfs:label "biological process involved in intraspecies interaction between organisms" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0051707 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." ; oboInOwl:hasAlternativeId "GO:0009613", "GO:0042828" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051707" ; a owl:Class ; rdfs:label "response to other organism" ; rdfs:subClassOf obo:GO_0043207, obo:GO_0044419 . obo:GO_0051709 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20287"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-03-20T04:48:41Z" ; oboInOwl:hasAlternativeId "GO:0044531", "GO:0052248", "GO:0052433", "GO:0052459" ; oboInOwl:hasExactSynonym "regulation of killing of cells of other organism" ; oboInOwl:hasNarrowSynonym "modulation by organism of apoptotic process in other organism involved in symbiotic interaction", "modulation of programmed cell death in other organism", "modulation of programmed cell death in other organism involved in symbiotic interaction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051709" ; a owl:Class ; rdfs:label "regulation of killing of cells of another organism" ; rdfs:subClassOf obo:GO_0031341, obo:GO_0035821, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031640 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031640 ] ) ] . obo:GO_0051711 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20287"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0052490" ; oboInOwl:hasExactSynonym "down regulation of killing of cells of another organism", "down-regulation of killing of cells of another organism", "downregulation of killing of cells of another organism", "negative regulation of killing of cells of other organism" ; oboInOwl:hasNarrowSynonym "inhibition of killing of cells of another organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051711" ; a owl:Class ; rdfs:label "negative regulation of killing of cells of another organism" ; rdfs:subClassOf obo:GO_0031342, obo:GO_0051709, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031640 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031640 ] ) ] . obo:GO_0051712 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20287"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0052330", "GO:0052388", "GO:0052501", "GO:0052518", "GO:0052529" ; oboInOwl:hasExactSynonym "positive regulation of killing of cells of other organism", "up regulation of killing of cells of another organism", "up-regulation of killing of cells of another organism", "upregulation of killing of cells of another organism" ; oboInOwl:hasNarrowSynonym "activation of killing of cells of another organism", "stimulation of killing of cells of another organism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction", "enhancement of other organism programmed cell death by organism" ; oboInOwl:id "GO:0051712" ; a owl:Class ; rdfs:label "positive regulation of killing of cells of another organism" ; rdfs:subClassOf obo:GO_0031343, obo:GO_0043068, obo:GO_0051709, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031640 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031640 ] ) ] . obo:GO_0051716 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051716" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "cellular response to stimulus" ; rdfs:subClassOf obo:GO_0009987, obo:GO_0050896 . obo:GO_0051726 obo:IAO_0000115 "Any process that modulates the rate or extent of progression through the cell cycle." ; oboInOwl:hasAlternativeId "GO:0000074", "GO:0007050", "GO:0071156", "GO:0071157", "GO:0071158", "GO:0071850" ; oboInOwl:hasExactSynonym "cell cycle modulation", "cell cycle regulation", "control of cell cycle progression", "modulation of cell cycle progression", "regulation of cell cycle progression", "regulation of progression through cell cycle" ; oboInOwl:hasNarrowSynonym "arrest of mitotic cell cycle progression", "cell cycle arrest", "mitotic cell cycle arrest", "negative regulation of cell cycle arrest", "positive regulation of cell cycle arrest", "regulation of cell cycle arrest" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cell cycle regulator", "tumor suppressor" ; oboInOwl:id "GO:0051726" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "regulation of cell cycle" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007049 ] ) ] . obo:GO_0051781 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell division." ; oboInOwl:hasExactSynonym "up regulation of cell division", "up-regulation of cell division", "upregulation of cell division" ; oboInOwl:hasNarrowSynonym "activation of cell division", "stimulation of cell division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051781" ; a owl:Class ; rdfs:label "positive regulation of cell division" ; rdfs:subClassOf obo:GO_0048522, obo:GO_0051302, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051301 ] ) ] . obo:GO_0051782 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." ; oboInOwl:hasExactSynonym "down regulation of cell division", "down-regulation of cell division", "downregulation of cell division" ; oboInOwl:hasNarrowSynonym "inhibition of cell division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051782" ; a owl:Class ; rdfs:label "negative regulation of cell division" ; rdfs:subClassOf obo:GO_0048523, obo:GO_0051302, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051301 ] ) ] . obo:GO_0051783 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051783" ; a owl:Class ; rdfs:label "regulation of nuclear division" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000280 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000280 ] ) ] . obo:GO_0051784 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." ; oboInOwl:hasExactSynonym "down regulation of nuclear division", "down-regulation of nuclear division", "downregulation of nuclear division" ; oboInOwl:hasNarrowSynonym "inhibition of nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051784" ; a owl:Class ; rdfs:label "negative regulation of nuclear division" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0051783, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000280 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0000280 ] ) ] . obo:GO_0051785 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." ; oboInOwl:hasExactSynonym "up regulation of nuclear division", "up-regulation of nuclear division", "upregulation of nuclear division" ; oboInOwl:hasNarrowSynonym "activation of nuclear division", "stimulation of nuclear division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051785" ; a owl:Class ; rdfs:label "positive regulation of nuclear division" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0051783, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000280 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000280 ] ) ] . obo:GO_0051873 obo:IAO_0000115 "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/18719"^^xsd:anyURI ; oboInOwl:hasAlternativeId "GO:0051852" ; oboInOwl:hasBroadSynonym "disruption by host of symbiont cells" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051873" ; a owl:Class ; rdfs:label "killing by host of symbiont cells" ; rdfs:subClassOf obo:GO_0031640, obo:GO_0051702, obo:GO_0098542 . obo:GO_0051917 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051917" ; a owl:Class ; rdfs:label "regulation of fibrinolysis" ; rdfs:subClassOf obo:GO_0030193, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042730 ] ) ] . obo:GO_0051918 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." ; oboInOwl:hasExactSynonym "down regulation of fibrinolysis", "down-regulation of fibrinolysis", "downregulation of fibrinolysis" ; oboInOwl:hasNarrowSynonym "inhibition of fibrinolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051918" ; a owl:Class ; rdfs:label "negative regulation of fibrinolysis" ; rdfs:subClassOf obo:GO_0030194, obo:GO_0032103, obo:GO_0048519, obo:GO_0051917, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042730 ] ) ] . obo:GO_0051919 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." ; oboInOwl:hasExactSynonym "up regulation of fibrinolysis", "up-regulation of fibrinolysis", "upregulation of fibrinolysis" ; oboInOwl:hasNarrowSynonym "activation of fibrinolysis", "stimulation of fibrinolysis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051919" ; a owl:Class ; rdfs:label "positive regulation of fibrinolysis" ; rdfs:subClassOf obo:GO_0030195, obo:GO_0048518, obo:GO_0051917, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042730 ] ) ] . obo:GO_0051930 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051930" ; a owl:Class ; rdfs:label "regulation of sensory perception of pain" ; rdfs:subClassOf obo:GO_0051931, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019233 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_0051931 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051931" ; a owl:Class ; rdfs:label "regulation of sensory perception" ; rdfs:subClassOf obo:GO_0031644, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007600 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007600 ] ) ] . obo:GO_0051932 obo:IAO_0000115 "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." ; oboInOwl:hasExactSynonym "GABAergic synaptic transmission", "synaptic transmission, GABA mediated", "synaptic transmission, gamma-aminobutyric acid mediated", "synaptic transmission, gamma-aminobutyric acid-ergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051932" ; a owl:Class ; rdfs:label "synaptic transmission, GABAergic" ; rdfs:subClassOf obo:GO_0007268 . obo:GO_0051937 obo:IAO_0000115 "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051937" ; a owl:Class ; rdfs:label "catecholamine transport" ; rdfs:subClassOf obo:GO_0015844, obo:GO_0015850 . obo:GO_0051938 obo:IAO_0000115 "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." ; oboInOwl:hasExactSynonym "L-glutamate uptake" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051938" ; a owl:Class ; rdfs:label "L-glutamate import" ; rdfs:subClassOf obo:GO_0006835, obo:GO_0015800, obo:GO_0015807, obo:GO_0042886 . obo:GO_0051952 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051952" ; a owl:Class ; rdfs:label "regulation of amine transport" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015837 ] ) ] . obo:GO_0051953 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of amine transport", "down-regulation of amine transport", "downregulation of amine transport" ; oboInOwl:hasNarrowSynonym "inhibition of amine transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051953" ; a owl:Class ; rdfs:label "negative regulation of amine transport" ; rdfs:subClassOf obo:GO_0051051, obo:GO_0051952, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0015837 ] ) ] . obo:GO_0051954 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "up regulation of amine transport", "up-regulation of amine transport", "upregulation of amine transport" ; oboInOwl:hasNarrowSynonym "activation of amine transport", "stimulation of amine transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051954" ; a owl:Class ; rdfs:label "positive regulation of amine transport" ; rdfs:subClassOf obo:GO_0051050, obo:GO_0051952, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015837 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0015837 ] ) ] . obo:GO_0051955 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051955" ; a owl:Class ; rdfs:label "regulation of amino acid transport" ; rdfs:subClassOf obo:GO_0032890, obo:GO_0051952, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006865 ] ) ] . obo:GO_0051956 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "down regulation of amino acid transport", "down-regulation of amino acid transport", "downregulation of amino acid transport", "negative regulation of amino acid transmembrane transport" ; oboInOwl:hasNarrowSynonym "inhibition of amino acid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051956" ; a owl:Class ; rdfs:label "negative regulation of amino acid transport" ; rdfs:subClassOf obo:GO_0032891, obo:GO_0051953, obo:GO_0051955, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006865 ] ) ] . obo:GO_0051957 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:hasExactSynonym "positive regulation of amino acid transmembrane transport", "up regulation of amino acid transport", "up-regulation of amino acid transport", "upregulation of amino acid transport" ; oboInOwl:hasNarrowSynonym "activation of amino acid transport", "stimulation of amino acid transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051957" ; a owl:Class ; rdfs:label "positive regulation of amino acid transport" ; rdfs:subClassOf obo:GO_0032892, obo:GO_0051954, obo:GO_0051955, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006865 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006865 ] ) ] . obo:GO_0051960 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051960" ; a owl:Class ; rdfs:label "regulation of nervous system development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007399 ] ) ] . obo:GO_0051961 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." ; oboInOwl:hasExactSynonym "down regulation of nervous system development", "down-regulation of nervous system development", "downregulation of nervous system development" ; oboInOwl:hasNarrowSynonym "inhibition of nervous system development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051961" ; a owl:Class ; rdfs:label "negative regulation of nervous system development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_0051960, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007399 ] ) ] . obo:GO_0051962 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." ; oboInOwl:hasExactSynonym "up regulation of nervous system development", "up-regulation of nervous system development", "upregulation of nervous system development" ; oboInOwl:hasNarrowSynonym "activation of nervous system development", "stimulation of nervous system development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051962" ; a owl:Class ; rdfs:label "positive regulation of nervous system development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0051240, obo:GO_0051960, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007399 ] ) ] . obo:GO_0051966 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051966" ; a owl:Class ; rdfs:label "regulation of synaptic transmission, glutamatergic" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035249 ] ) ] . obo:GO_0051967 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." ; oboInOwl:hasExactSynonym "down regulation of synaptic transmission, glutamatergic", "down-regulation of synaptic transmission, glutamatergic", "downregulation of synaptic transmission, glutamatergic" ; oboInOwl:hasNarrowSynonym "inhibition of synaptic transmission, glutamatergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051967" ; a owl:Class ; rdfs:label "negative regulation of synaptic transmission, glutamatergic" ; rdfs:subClassOf obo:GO_0050805, obo:GO_0051966, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035249 ] ) ] . obo:GO_0051968 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." ; oboInOwl:hasExactSynonym "up regulation of synaptic transmission, glutamatergic", "up-regulation of synaptic transmission, glutamatergic", "upregulation of synaptic transmission, glutamatergic" ; oboInOwl:hasNarrowSynonym "activation of synaptic transmission, glutamatergic", "stimulation of synaptic transmission, glutamatergic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051968" ; a owl:Class ; rdfs:label "positive regulation of synaptic transmission, glutamatergic" ; rdfs:subClassOf obo:GO_0050806, obo:GO_0051966, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035249 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035249 ] ) ] . obo:GO_0051969 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." ; oboInOwl:hasExactSynonym "regulation of conduction of nerve impulse" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051969" ; a owl:Class ; rdfs:label "regulation of transmission of nerve impulse" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0031644, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0019226 ] ) ] . obo:GO_0051970 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." ; oboInOwl:hasExactSynonym "down regulation of transmission of nerve impulse", "down-regulation of transmission of nerve impulse", "downregulation of transmission of nerve impulse", "negative regulation of conduction of nerve impulse" ; oboInOwl:hasNarrowSynonym "inhibition of transmission of nerve impulse" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051970" ; a owl:Class ; rdfs:label "negative regulation of transmission of nerve impulse" ; rdfs:subClassOf obo:GO_0010648, obo:GO_0031645, obo:GO_0051969, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019226 ] ) ] . obo:GO_0051971 obo:IAO_0000115 "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." ; oboInOwl:hasExactSynonym "positive regulation of conduction of nerve impulse", "up regulation of transmission of nerve impulse", "up-regulation of transmission of nerve impulse", "upregulation of transmission of nerve impulse" ; oboInOwl:hasNarrowSynonym "activation of transmission of nerve impulse", "stimulation of transmission of nerve impulse" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051971" ; a owl:Class ; rdfs:label "positive regulation of transmission of nerve impulse" ; rdfs:subClassOf obo:GO_0010647, obo:GO_0031646, obo:GO_0051969, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019226 ] ) ] . obo:GO_0051983 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051983" ; a owl:Class ; rdfs:label "regulation of chromosome segregation" ; rdfs:subClassOf obo:GO_0010564, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007059 ] ) ] . obo:GO_0051984 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." ; oboInOwl:hasExactSynonym "up regulation of chromosome segregation", "up-regulation of chromosome segregation", "upregulation of chromosome segregation" ; oboInOwl:hasNarrowSynonym "activation of chromosome segregation", "stimulation of chromosome segregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051984" ; a owl:Class ; rdfs:label "positive regulation of chromosome segregation" ; rdfs:subClassOf obo:GO_0051983, obo:GO_0090068, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007059 ] ) ] . obo:GO_0051985 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." ; oboInOwl:hasExactSynonym "down regulation of chromosome segregation", "down-regulation of chromosome segregation", "downregulation of chromosome segregation" ; oboInOwl:hasNarrowSynonym "inhibition of chromosome segregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0051985" ; a owl:Class ; rdfs:label "negative regulation of chromosome segregation" ; rdfs:subClassOf obo:GO_0010948, obo:GO_0051983, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007059 ] ) ] . obo:GO_0055062 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055062" ; a owl:Class ; rdfs:label "phosphate ion homeostasis" ; rdfs:subClassOf obo:GO_0098771 . obo:GO_0055064 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055064" ; a owl:Class ; rdfs:label "chloride ion homeostasis" ; rdfs:subClassOf obo:GO_0055081, obo:GO_0098771 . obo:GO_0055067 obo:IAO_0000115 "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." ; obo:IAO_0100001 "GO:0055080" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055067" ; a owl:Class ; rdfs:comment "This term was obsoleted because it is an unnecessary grouping class." ; rdfs:label "obsolete monovalent inorganic cation homeostasis" ; owl:deprecated true . obo:GO_0055069 obo:IAO_0000115 "OBSOLETE. Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24464"^^xsd:anyURI ; oboInOwl:consider "GO:0006882", "GO:0180002" ; oboInOwl:hasBroadSynonym "zinc homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055069" ; a owl:Class ; rdfs:comment "The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent. For homeostasis terms, we would like to specify whether the homeostasis takes place intracellularly or at the level of the organism." ; rdfs:label "obsolete zinc ion homeostasis" ; owl:deprecated true . obo:GO_0055071 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." ; oboInOwl:hasBroadSynonym "manganese homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055071" ; a owl:Class ; rdfs:label "manganese ion homeostasis" ; rdfs:subClassOf obo:GO_0055080, obo:GO_0098771 . obo:GO_0055074 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." ; oboInOwl:hasExactSynonym "regulation of calcium ion concentration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055074" ; a owl:Class ; rdfs:label "calcium ion homeostasis" ; rdfs:subClassOf obo:GO_0055080, obo:GO_0098771 . obo:GO_0055080 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "cation homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055080" ; a owl:Class ; rdfs:label "monoatomic cation homeostasis" ; rdfs:subClassOf obo:GO_0050801 . obo:GO_0055081 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "anion homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055081" ; a owl:Class ; rdfs:label "monoatomic anion homeostasis" ; rdfs:subClassOf obo:GO_0050801 . obo:GO_0055082 obo:IAO_0000115 "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24514"^^xsd:anyURI ; oboInOwl:hasExactSynonym "cellular chemical homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055082" ; a owl:Class ; rdfs:label "intracellular chemical homeostasis" ; rdfs:subClassOf obo:GO_0019725, obo:GO_0048878 . obo:GO_0055085 obo:IAO_0000115 "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2015-10-21T13:22:47Z" ; oboInOwl:hasAlternativeId "GO:0090662" ; oboInOwl:hasExactSynonym "membrane transport" ; oboInOwl:hasNarrowSynonym "ATP hydrolysis coupled transmembrane transport" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055085" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pombe, go:goslim_yeast ; a owl:Class ; rdfs:comment "Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes." ; rdfs:label "transmembrane transport" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0009987 . obo:GO_0055086 obo:IAO_0000115 "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." ; oboInOwl:hasExactSynonym "nucleobase, nucleoside and nucleotide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "nucleobase, nucleoside and nucleotide metabolic process" ; oboInOwl:id "GO:0055086" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_generic, go:goslim_pombe, go:goslim_yeast, go:prokaryote_subset ; a owl:Class ; rdfs:label "nucleobase-containing small molecule metabolic process" ; rdfs:subClassOf obo:GO_0006139, obo:GO_0044281 . obo:GO_0055117 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055117" ; a owl:Class ; rdfs:label "regulation of cardiac muscle contraction" ; rdfs:subClassOf obo:GO_0006942, obo:GO_0008016, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060048 ] ) ] . obo:GO_0055118 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055118" ; a owl:Class ; rdfs:label "negative regulation of cardiac muscle contraction" ; rdfs:subClassOf obo:GO_0045822, obo:GO_0045988, obo:GO_0055117, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060048 ] ) ] . obo:GO_0055127 obo:IAO_0000115 "The transmission of vibrations via ossicles to the inner ear." ; oboInOwl:created_by "jid" ; oboInOwl:creation_date "2009-10-13T10:59:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0055127" ; a owl:Class ; rdfs:label "vibrational conductance of sound to the inner ear" ; rdfs:subClassOf obo:GO_0032501, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007605 ] . obo:GO_0060004 obo:IAO_0000115 "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." ; oboInOwl:hasDbXref "Wikipedia:Reflex" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060004" ; a owl:Class ; rdfs:label "reflex" ; rdfs:subClassOf obo:GO_0009605 . obo:GO_0060005 obo:IAO_0000115 "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060005" ; a owl:Class ; rdfs:label "vestibular reflex" ; rdfs:subClassOf obo:GO_0060004 . obo:GO_0060047 obo:IAO_0000115 "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." ; oboInOwl:hasExactSynonym "heart beating" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cardiac contraction", "hemolymph circulation" ; oboInOwl:id "GO:0060047" ; a owl:Class ; rdfs:label "heart contraction" ; rdfs:subClassOf obo:GO_0003015, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0008015 ] . obo:GO_0060048 obo:IAO_0000115 "Muscle contraction of cardiac muscle tissue." ; oboInOwl:hasExactSynonym "heart muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060048" ; a owl:Class ; rdfs:label "cardiac muscle contraction" ; rdfs:subClassOf obo:GO_0006941, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060047 ] . obo:GO_0060049 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." ; oboInOwl:hasExactSynonym "regulation of protein amino acid glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060049" ; a owl:Class ; rdfs:label "regulation of protein glycosylation" ; rdfs:subClassOf obo:GO_0010559, obo:GO_0031399, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006486 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006486 ] ) ] . obo:GO_0060050 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." ; oboInOwl:hasExactSynonym "positive regulation of protein amino acid glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060050" ; a owl:Class ; rdfs:label "positive regulation of protein glycosylation" ; rdfs:subClassOf obo:GO_0010560, obo:GO_0031401, obo:GO_0060049, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006486 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006486 ] ) ] . obo:GO_0060051 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." ; oboInOwl:hasExactSynonym "negative regulation of protein amino acid glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060051" ; a owl:Class ; rdfs:label "negative regulation of protein glycosylation" ; rdfs:subClassOf obo:GO_0010561, obo:GO_0031400, obo:GO_0060049, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006486 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006486 ] ) ] . obo:GO_0060055 obo:IAO_0000115 "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060055" ; a owl:Class ; rdfs:label "angiogenesis involved in wound healing" ; rdfs:subClassOf obo:GO_0001525, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001525 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042060 ] ) ] . obo:GO_0060073 obo:IAO_0000115 "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." ; oboInOwl:hasDbXref "Wikipedia:Urination" ; oboInOwl:hasExactSynonym "urination", "urine voiding" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060073" ; a owl:Class ; rdfs:label "micturition" ; rdfs:subClassOf obo:GO_0003014, obo:GO_0007588 . obo:GO_0060078 obo:IAO_0000115 "Any process that modulates the potential difference across a post-synaptic membrane." ; oboInOwl:hasExactSynonym "regulation of post-synaptic membrane potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060078" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "regulation of postsynaptic membrane potential" ; rdfs:subClassOf obo:GO_0042391 . obo:GO_0060079 obo:IAO_0000115 "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." ; oboInOwl:hasExactSynonym "regulation of excitatory post-synaptic membrane potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of EPSP" ; oboInOwl:id "GO:0060079" ; a owl:Class ; rdfs:label "excitatory postsynaptic potential" ; rdfs:subClassOf obo:GO_0060078, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0099565 ] . obo:GO_0060082 obo:IAO_0000115 "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." ; oboInOwl:hasExactSynonym "nictitating membrane reflex" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060082" ; a owl:Class ; rdfs:label "eye blink reflex" ; rdfs:subClassOf obo:GO_0060004 . obo:GO_0060083 obo:IAO_0000115 "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "smooth muscle contraction involved in urination", "urinary bladder smooth muscle contraction involved in micturition" ; oboInOwl:id "GO:0060083" ; a owl:Class ; rdfs:label "smooth muscle contraction involved in micturition" ; rdfs:subClassOf obo:GO_0014832, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006939 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060073 ] ) ] . obo:GO_0060084 obo:IAO_0000115 "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "synaptic transmission involved in urination" ; oboInOwl:id "GO:0060084" ; a owl:Class ; rdfs:label "synaptic transmission involved in micturition" ; rdfs:subClassOf obo:GO_0007274, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007268 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060073 ] ) ] . obo:GO_0060089 obo:IAO_0000115 "A compound molecular function in which an effector function is controlled by one or more regulatory components." ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0060089" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate, go:goslim_generic, go:goslim_pir, go:prokaryote_subset ; a owl:Class ; rdfs:label "molecular transducer activity" ; rdfs:subClassOf obo:GO_0003674 . obo:GO_0060123 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060123" ; a owl:Class ; rdfs:label "regulation of growth hormone secretion" ; rdfs:subClassOf obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030252 ] ) ] . obo:GO_0060124 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060124" ; a owl:Class ; rdfs:label "positive regulation of growth hormone secretion" ; rdfs:subClassOf obo:GO_0060123, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030252 ] ) ] . obo:GO_0060125 obo:IAO_0000115 "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060125" ; a owl:Class ; rdfs:label "negative regulation of growth hormone secretion" ; rdfs:subClassOf obo:GO_0060123, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030252 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030252 ] ) ] . obo:GO_0060136 obo:IAO_0000115 "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060136" ; a owl:Class ; rdfs:label "embryonic process involved in female pregnancy" ; rdfs:subClassOf obo:GO_0048609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007565 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009792 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0022414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007565 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009790 ] ) ] . obo:GO_0060156 obo:IAO_0000115 "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." ; oboInOwl:hasExactSynonym "milk ejection" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060156" ; a owl:Class ; rdfs:label "milk ejection reflex" ; rdfs:subClassOf obo:GO_0007589, obo:GO_0032941, obo:GO_0060004, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007595 ] . obo:GO_0060173 obo:IAO_0000115 "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." ; oboInOwl:hasDbXref "Wikipedia:Limb_development" ; oboInOwl:hasExactSynonym "paired limb/fin development" ; oboInOwl:hasNarrowSynonym "limb bud development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060173" ; a owl:Class ; rdfs:label "limb development" ; rdfs:subClassOf obo:GO_0048736 . obo:GO_0060249 obo:IAO_0000115 "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." ; oboInOwl:hasExactSynonym "anatomical structure maintenance" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060249" ; a owl:Class ; rdfs:label "anatomical structure homeostasis" ; rdfs:subClassOf obo:GO_0048871 . obo:GO_0060255 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060255" ; a owl:Class ; rdfs:label "regulation of macromolecule metabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043170 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043170 ] ) ] . obo:GO_0060259 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." ; oboInOwl:hasExactSynonym "regulation of feeding behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060259" ; a owl:Class ; rdfs:label "regulation of feeding behavior" ; rdfs:subClassOf obo:GO_0050795, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007631 ] ) ] . obo:GO_0060263 obo:IAO_0000115 "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060263" ; a owl:Class ; rdfs:label "regulation of respiratory burst" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045730 ] ) ] . obo:GO_0060264 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasBroadSynonym "regulation of respiratory burst involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060264" ; a owl:Class ; rdfs:label "regulation of respiratory burst involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002697, obo:GO_0045088, obo:GO_0050727, obo:GO_0051239, obo:GO_0060263, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002536 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002536 ] ) ] . obo:GO_0060265 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasBroadSynonym "positive regulation of respiratory burst involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060265" ; a owl:Class ; rdfs:label "positive regulation of respiratory burst involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0045089, obo:GO_0050729, obo:GO_0051240, obo:GO_0060264, obo:GO_0060267, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002536 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002536 ] ) ] . obo:GO_0060266 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasBroadSynonym "negative regulation of respiratory burst involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060266" ; a owl:Class ; rdfs:label "negative regulation of respiratory burst involved in inflammatory response" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0045824, obo:GO_0050728, obo:GO_0051241, obo:GO_0060264, obo:GO_0060268, obo:GO_0060284, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002536 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002536 ] ) ] . obo:GO_0060267 obo:IAO_0000115 "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060267" ; a owl:Class ; rdfs:label "positive regulation of respiratory burst" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0060263, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045730 ] ) ] . obo:GO_0060268 obo:IAO_0000115 "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060268" ; a owl:Class ; rdfs:label "negative regulation of respiratory burst" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0060263, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045730 ] ) ] . obo:GO_0060271 obo:IAO_0000115 "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." ; obo:RO_0002161 obo:NCBITaxon_3176, obo:NCBITaxon_3312, obo:NCBITaxon_3378, obo:NCBITaxon_3398, obo:NCBITaxon_4890, obo:NCBITaxon_5782 ; oboInOwl:hasAlternativeId "GO:0042384" ; oboInOwl:hasDbXref "Reactome:R-HSA-5617833.2" ; oboInOwl:hasExactSynonym "ciliogenesis", "cilium formation", "microtubule-based flagellum assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "cilium biogenesis", "cilium morphogenesis", "cilium organization" ; oboInOwl:id "GO:0060271" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent." ; rdfs:label "cilium assembly" ; rdfs:subClassOf obo:GO_0044782, obo:GO_0070925, obo:GO_0120031, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0035082 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0035735 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0061512 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0097712 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_1905349 ] . obo:GO_0060284 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060284" ; a owl:Class ; rdfs:label "regulation of cell development" ; rdfs:subClassOf obo:GO_0045595, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048468 ] ) ] . obo:GO_0060285 obo:IAO_0000115 "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." ; oboInOwl:hasAlternativeId "GO:0071974" ; oboInOwl:hasExactSynonym "cilium cell motility", "microtubule-based flagellar cell motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ciliary cell motility" ; oboInOwl:id "GO:0060285" ; a owl:Class ; rdfs:comment "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent." ; rdfs:label "cilium-dependent cell motility" ; rdfs:subClassOf obo:GO_0001539, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0003341 ] . obo:GO_0060294 obo:IAO_0000115 "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060294" ; a owl:Class ; rdfs:label "cilium movement involved in cell motility" ; rdfs:subClassOf obo:GO_0003341, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0003341 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:GO_0060295 obo:IAO_0000115 "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060295" ; a owl:Class ; rdfs:label "regulation of cilium movement involved in cell motility" ; rdfs:subClassOf obo:GO_0003352, obo:GO_1902019, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060294 ] ) ] . obo:GO_0060326 obo:IAO_0000115 "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060326" ; a owl:Class ; rdfs:label "cell chemotaxis" ; rdfs:subClassOf obo:GO_0006935, obo:GO_0016477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0070887 ] . obo:GO_0060341 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." ; oboInOwl:hasExactSynonym "regulation of cellular localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060341" ; a owl:Class ; rdfs:label "regulation of cellular localization" ; rdfs:subClassOf obo:GO_0032879, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051641 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051641 ] ) ] . obo:GO_0060343 obo:IAO_0000115 "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." ; oboInOwl:hasExactSynonym "trabeculation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "trabecula biogenesis" ; oboInOwl:id "GO:0060343" ; a owl:Class ; rdfs:label "trabecula formation" ; rdfs:subClassOf obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009887 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0061383 ] . obo:GO_0060348 obo:IAO_0000115 "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060348" ; a owl:Class ; rdfs:label "bone development" ; rdfs:subClassOf obo:GO_0048513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001501 ] . obo:GO_0060349 obo:IAO_0000115 "The process in which bones are generated and organized." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060349" ; a owl:Class ; rdfs:label "bone morphogenesis" ; rdfs:subClassOf obo:GO_0009887, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048705 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060348 ] . obo:GO_0060350 obo:IAO_0000115 "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060350" ; a owl:Class ; rdfs:label "endochondral bone morphogenesis" ; rdfs:subClassOf obo:GO_0060349 . obo:GO_0060351 obo:IAO_0000115 "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060351" ; a owl:Class ; rdfs:label "cartilage development involved in endochondral bone morphogenesis" ; rdfs:subClassOf obo:GO_0051216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060350 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0051216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060350 ] ) ] . obo:GO_0060374 obo:IAO_0000115 "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060374" ; a owl:Class ; rdfs:label "mast cell differentiation" ; rdfs:subClassOf obo:GO_0002573 . obo:GO_0060375 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060375" ; a owl:Class ; rdfs:label "regulation of mast cell differentiation" ; rdfs:subClassOf obo:GO_0002761, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060374 ] ) ] . obo:GO_0060376 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060376" ; a owl:Class ; rdfs:label "positive regulation of mast cell differentiation" ; rdfs:subClassOf obo:GO_0002763, obo:GO_0060375, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060374 ] ) ] . obo:GO_0060377 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060377" ; a owl:Class ; rdfs:label "negative regulation of mast cell differentiation" ; rdfs:subClassOf obo:GO_0002762, obo:GO_0060375, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060374 ] ) ] . obo:GO_0060405 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060405" ; a owl:Class ; rdfs:label "regulation of penile erection" ; rdfs:subClassOf obo:GO_0051239, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043084 ] ) ] . obo:GO_0060406 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060406" ; a owl:Class ; rdfs:label "positive regulation of penile erection" ; rdfs:subClassOf obo:GO_0051240, obo:GO_0060405, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0043084 ] ) ] . obo:GO_0060407 obo:IAO_0000115 "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060407" ; a owl:Class ; rdfs:label "negative regulation of penile erection" ; rdfs:subClassOf obo:GO_0051241, obo:GO_0060405, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0043084 ] ) ] . obo:GO_0060425 obo:IAO_0000115 "The process in which the anatomical structures of the lung are generated and organized." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060425" ; a owl:Class ; rdfs:label "lung morphogenesis" ; rdfs:subClassOf obo:GO_0009887, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] . obo:GO_0060429 obo:IAO_0000115 "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060429" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "epithelium development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0060441 obo:IAO_0000115 "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." ; oboInOwl:hasExactSynonym "lung branching morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060441" ; a owl:Class ; rdfs:label "epithelial tube branching involved in lung morphogenesis" ; rdfs:subClassOf obo:GO_0048754, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060425 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0048754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060425 ] ) ] . obo:GO_0060452 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of cardiac muscle contraction." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060452" ; a owl:Class ; rdfs:label "positive regulation of cardiac muscle contraction" ; rdfs:subClassOf obo:GO_0045823, obo:GO_0045989, obo:GO_0055117, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060048 ] ) ] . obo:GO_0060453 obo:IAO_0000115 "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060453" ; a owl:Class ; rdfs:label "regulation of gastric acid secretion" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0051046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001696 ] ) ] . obo:GO_0060454 obo:IAO_0000115 "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060454" ; a owl:Class ; rdfs:label "positive regulation of gastric acid secretion" ; rdfs:subClassOf obo:GO_0051047, obo:GO_0060453, obo:GO_0060456, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001696 ] ) ] . obo:GO_0060455 obo:IAO_0000115 "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060455" ; a owl:Class ; rdfs:label "negative regulation of gastric acid secretion" ; rdfs:subClassOf obo:GO_0051048, obo:GO_0060453, obo:GO_0060457, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001696 ] ) ] . obo:GO_0060456 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060456" ; a owl:Class ; rdfs:label "positive regulation of digestive system process" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022600 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022600 ] ) ] . obo:GO_0060457 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060457" ; a owl:Class ; rdfs:label "negative regulation of digestive system process" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022600 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022600 ] ) ] . obo:GO_0060462 obo:IAO_0000115 "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060462" ; a owl:Class ; rdfs:label "lung lobe development" ; rdfs:subClassOf obo:GO_0048856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] . obo:GO_0060463 obo:IAO_0000115 "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060463" ; a owl:Class ; rdfs:label "lung lobe morphogenesis" ; rdfs:subClassOf obo:GO_0009653, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060425 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060462 ] . obo:GO_0060464 obo:IAO_0000115 "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060464" ; a owl:Class ; rdfs:label "lung lobe formation" ; rdfs:subClassOf obo:GO_0048646, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060463 ] . obo:GO_0060467 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060467" ; a owl:Class ; rdfs:label "negative regulation of fertilization" ; rdfs:subClassOf obo:GO_0080154, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:GO_0060474 obo:IAO_0000115 "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of sperm motility involved in capacitation" ; oboInOwl:id "GO:0060474" ; a owl:Class ; rdfs:label "positive regulation of flagellated sperm motility involved in capacitation" ; rdfs:subClassOf obo:GO_0022414, obo:GO_1902093, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_1902093 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048240 ] ) ] . obo:GO_0060491 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of cell projection assembly." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cell projection formation" ; oboInOwl:id "GO:0060491" ; a owl:Class ; rdfs:label "regulation of cell projection assembly" ; rdfs:subClassOf obo:GO_0031344, obo:GO_0044087, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030031 ] ) ] . obo:GO_0060495 obo:IAO_0000115 "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." ; oboInOwl:hasExactSynonym "cell-cell signalling involved in lung development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060495" ; a owl:Class ; rdfs:label "cell-cell signaling involved in lung development" ; rdfs:subClassOf obo:GO_0007267, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007267 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] ) ] . obo:GO_0060541 obo:IAO_0000115 "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-04-10T08:55:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060541" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "respiratory system development" ; rdfs:subClassOf obo:GO_0048731 . obo:GO_0060560 obo:IAO_0000115 "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-04-28T08:42:53Z" ; oboInOwl:hasExactSynonym "differential growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060560" ; a owl:Class ; rdfs:label "developmental growth involved in morphogenesis" ; rdfs:subClassOf obo:GO_0048589, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0048589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] ) ] . obo:GO_0060561 obo:IAO_0000115 "Any apoptotic process that contributes to the shaping of an anatomical structure." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-04-28T09:17:27Z" ; oboInOwl:hasNarrowSynonym "apoptosis involved in morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "apoptosis involved in development", "morphogenetic apoptosis" ; oboInOwl:id "GO:0060561" ; a owl:Class ; rdfs:label "apoptotic process involved in morphogenesis" ; rdfs:subClassOf obo:GO_1902742, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009653 ] ) ] . obo:GO_0060562 obo:IAO_0000115 "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-04-28T09:33:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060562" ; a owl:Class ; rdfs:label "epithelial tube morphogenesis" ; rdfs:subClassOf obo:GO_0002009, obo:GO_0035239 . obo:GO_0060606 obo:IAO_0000115 "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-05-15T09:44:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060606" ; a owl:Class ; rdfs:label "tube closure" ; rdfs:subClassOf obo:GO_0035148 . obo:GO_0060623 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-05-18T02:12:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060623" ; a owl:Class ; rdfs:label "regulation of chromosome condensation" ; rdfs:subClassOf obo:GO_0033044, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030261 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030261 ] ) ] . obo:GO_0060627 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-05-18T02:29:43Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060627" ; a owl:Class ; rdfs:label "regulation of vesicle-mediated transport" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016192 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016192 ] ) ] . obo:GO_0060632 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-05-18T03:07:02Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060632" ; a owl:Class ; rdfs:label "regulation of microtubule-based movement" ; rdfs:subClassOf obo:GO_0032886, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007018 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007018 ] ) ] . obo:GO_0060688 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-06-05T12:41:44Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060688" ; a owl:Class ; rdfs:label "regulation of morphogenesis of a branching structure" ; rdfs:subClassOf obo:GO_0022603, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001763 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001763 ] ) ] . obo:GO_0060759 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-06-22T02:56:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060759" ; a owl:Class ; rdfs:label "regulation of response to cytokine stimulus" ; rdfs:subClassOf obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034097 ] ) ] . obo:GO_0060760 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-06-22T02:58:04Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060760" ; a owl:Class ; rdfs:label "positive regulation of response to cytokine stimulus" ; rdfs:subClassOf obo:GO_0048584, obo:GO_0060759, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034097 ] ) ] . obo:GO_0060761 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-06-22T02:59:57Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060761" ; a owl:Class ; rdfs:label "negative regulation of response to cytokine stimulus" ; rdfs:subClassOf obo:GO_0048585, obo:GO_0060759, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034097 ] ) ] . obo:GO_0060764 obo:IAO_0000115 "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-07-06T09:24:53Z" ; oboInOwl:hasExactSynonym "cell-cell signalling involved in mammary gland development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060764" ; a owl:Class ; rdfs:label "cell-cell signaling involved in mammary gland development" ; rdfs:subClassOf obo:GO_0007267, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007267 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030879 ] ) ] . obo:GO_0060784 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-07-31T01:46:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060784" ; a owl:Class ; rdfs:label "regulation of cell proliferation involved in tissue homeostasis" ; rdfs:subClassOf obo:GO_0042127, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048873 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042127 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001894 ] ) ] . obo:GO_0060785 obo:IAO_0000115 "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-07-31T01:49:54Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060785" ; a owl:Class ; rdfs:label "regulation of apoptosis involved in tissue homeostasis" ; rdfs:subClassOf obo:GO_0042981, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048873 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001894 ] ) ] . obo:GO_0060786 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-07-31T01:55:19Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060786" ; a owl:Class ; rdfs:label "regulation of cell differentiation involved in tissue homeostasis" ; rdfs:subClassOf obo:GO_0045595, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048873 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045595 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0001894 ] ) ] . obo:GO_0060841 obo:IAO_0000115 "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-08-12T10:14:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060841" ; a owl:Class ; rdfs:label "venous blood vessel development" ; rdfs:subClassOf obo:GO_0001568 . obo:GO_0060916 obo:IAO_0000115 "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2009-09-18T11:50:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060916" ; a owl:Class ; rdfs:label "mesenchymal cell proliferation involved in lung development" ; rdfs:subClassOf obo:GO_0010463, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0010463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030324 ] ) ] . obo:GO_0060986 obo:IAO_0000115 "The regulated release of a hormone into the circulatory system." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-01-11T09:03:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0060986" ; a owl:Class ; rdfs:label "endocrine hormone secretion" ; rdfs:subClassOf obo:GO_0046879, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0050886 ] . obo:GO_0061007 obo:IAO_0000115 "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-01-22T09:09:10Z" ; oboInOwl:hasExactSynonym "hepatobiliary system process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061007" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "hepaticobiliary system process" ; rdfs:subClassOf obo:GO_0003008 . obo:GO_0061024 obo:IAO_0000115 "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-02-08T02:43:11Z" ; oboInOwl:hasAlternativeId "GO:0016044", "GO:0044802" ; oboInOwl:hasExactSynonym "cellular membrane organisation", "cellular membrane organization", "membrane organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "membrane organization and biogenesis", "single-organism membrane organization" ; oboInOwl:id "GO:0061024" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_drosophila, go:goslim_generic, go:goslim_pir, go:goslim_pombe, go:prokaryote_subset ; a owl:Class ; rdfs:label "membrane organization" ; rdfs:subClassOf obo:GO_0016043 . obo:GO_0061025 obo:IAO_0000115 "The membrane organization process that joins two lipid bilayers to form a single membrane." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2010-02-08T02:48:06Z" ; oboInOwl:hasAlternativeId "GO:0006944", "GO:0044801" ; oboInOwl:hasDbXref "Wikipedia:Lipid_bilayer_fusion" ; oboInOwl:hasExactSynonym "cellular membrane fusion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single-organism membrane fusion" ; oboInOwl:id "GO:0061025" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "membrane fusion" ; rdfs:subClassOf obo:GO_0061024 . obo:GO_0061035 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-09T03:41:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061035" ; a owl:Class ; rdfs:label "regulation of cartilage development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051216 ] ) ] . obo:GO_0061036 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-09T03:41:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061036" ; a owl:Class ; rdfs:label "positive regulation of cartilage development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0051240, obo:GO_0061035, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051216 ] ) ] . obo:GO_0061037 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-09T03:41:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061037" ; a owl:Class ; rdfs:label "negative regulation of cartilage development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_0061035, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051216 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051216 ] ) ] . obo:GO_0061041 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-25T10:14:37Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061041" ; a owl:Class ; rdfs:label "regulation of wound healing" ; rdfs:subClassOf obo:GO_1903034, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042060 ] ) ] . obo:GO_0061045 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-25T10:33:30Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061045" ; a owl:Class ; rdfs:label "negative regulation of wound healing" ; rdfs:subClassOf obo:GO_0032102, obo:GO_0061041, obo:GO_1903035, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042060 ] ) ] . obo:GO_0061046 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-25T10:41:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061046" ; a owl:Class ; rdfs:label "regulation of branching involved in lung morphogenesis" ; rdfs:subClassOf obo:GO_0060688, obo:GO_1905330, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060441 ] ) ] . obo:GO_0061047 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-25T10:50:01Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061047" ; a owl:Class ; rdfs:label "positive regulation of branching involved in lung morphogenesis" ; rdfs:subClassOf obo:GO_0051240, obo:GO_0061046, obo:GO_1905332, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060441 ] ) ] . obo:GO_0061048 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-02-25T10:51:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061048" ; a owl:Class ; rdfs:label "negative regulation of branching involved in lung morphogenesis" ; rdfs:subClassOf obo:GO_0051241, obo:GO_0061046, obo:GO_1905331, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060441 ] ) ] . obo:GO_0061116 obo:IAO_0000115 "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-05-17T07:21:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061116" ; a owl:Class ; rdfs:label "ductus venosus closure" ; rdfs:subClassOf obo:GO_0048845 . obo:GO_0061138 obo:IAO_0000115 "The process in which the anatomical structures of a branched epithelium are generated and organized." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-05-25T09:05:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061138" ; a owl:Class ; rdfs:label "morphogenesis of a branching epithelium" ; rdfs:subClassOf obo:GO_0001763, obo:GO_0002009 . obo:GO_0061383 obo:IAO_0000115 "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-12-02T08:51:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061383" ; a owl:Class ; rdfs:label "trabecula morphogenesis" ; rdfs:subClassOf obo:GO_0009653 . obo:GO_0061448 obo:IAO_0000115 "The progression of a connective tissue over time, from its formation to the mature structure." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2012-03-22T12:53:41Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061448" ; a owl:Class ; rdfs:label "connective tissue development" ; rdfs:subClassOf obo:GO_0009888 . obo:GO_0061512 obo:IAO_0000115 "A process in which a protein is transported to, or maintained in, a location within a cilium." ; obo:RO_0002161 obo:NCBITaxon_3176, obo:NCBITaxon_3312, obo:NCBITaxon_3378, obo:NCBITaxon_3398, obo:NCBITaxon_4890, obo:NCBITaxon_5782 ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-03-22T15:41:44Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061512" ; a owl:Class ; rdfs:label "protein localization to cilium" ; rdfs:subClassOf obo:GO_0033365 . obo:GO_0061526 obo:IAO_0000115 "The regulated release of acetylcholine by a cell." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-06-21T15:40:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061526" ; a owl:Class ; rdfs:label "acetylcholine secretion" ; rdfs:subClassOf obo:GO_0015870, obo:GO_0023061 . obo:GO_0061534 obo:IAO_0000115 "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-06-21T16:10:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061534" ; a owl:Class ; rdfs:label "gamma-aminobutyric acid secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0007269, obo:GO_0014051, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051932 ] . obo:GO_0061535 obo:IAO_0000115 "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-06-21T16:14:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061535" ; a owl:Class ; rdfs:label "glutamate secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0007269, obo:GO_0014047, obo:GO_0051938, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0035249 ] . obo:GO_0061695 obo:IAO_0000115 "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2015-05-06T11:22:38Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0061695" ; a owl:Class ; rdfs:label "transferase complex, transferring phosphorus-containing groups" ; rdfs:subClassOf obo:GO_1990234 . obo:GO_0061696 obo:IAO_0000115 "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2015-05-06T13:11:18Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0061696" ; a owl:Class ; rdfs:label "pituitary gonadotropin complex" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] . obo:GO_0061727 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2015-07-21T17:25:57Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061727" ; a owl:Class ; rdfs:label "methylglyoxal catabolic process to lactate" ; rdfs:subClassOf obo:GO_0006089, obo:GO_0051596 . obo:GO_0061844 obo:IAO_0000115 "An immune response against microbes mediated by anti-microbial peptides in body fluid." ; oboInOwl:hasBroadSynonym "peptide-mediated antimicrobial humoral response" ; oboInOwl:hasExactSynonym "antimicrobial peptide-mediated antimicrobial humoral response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061844" ; a owl:Class ; rdfs:label "antimicrobial humoral immune response mediated by antimicrobial peptide" ; rdfs:subClassOf obo:GO_0019730 . obo:GO_0061983 obo:IAO_0000115 "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-02-14T22:37:44Z" ; oboInOwl:hasExactSynonym "second meiotic division" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0061983" ; a owl:Class ; rdfs:label "meiosis II cell cycle process" ; rdfs:subClassOf obo:GO_1903046 . obo:GO_0062012 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-03-19T14:11:54Z" ; oboInOwl:hasExactSynonym "regulation of small molecule metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062012" ; a owl:Class ; rdfs:label "regulation of small molecule metabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044281 ] ) ] . obo:GO_0062013 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-03-19T14:25:10Z" ; oboInOwl:hasExactSynonym "positive regulation of small molecule metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062013" ; a owl:Class ; rdfs:label "positive regulation of small molecule metabolic process" ; rdfs:subClassOf obo:GO_0009893, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044281 ] ) ] . obo:GO_0062014 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-03-19T14:27:23Z" ; oboInOwl:hasExactSynonym "negative regulation of small molecule metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062014" ; a owl:Class ; rdfs:label "negative regulation of small molecule metabolic process" ; rdfs:subClassOf obo:GO_0009892, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044281 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044281 ] ) ] . obo:GO_0062023 obo:IAO_0000115 "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-04-13T12:47:21Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0062023" ; a owl:Class ; rdfs:label "collagen-containing extracellular matrix" ; rdfs:subClassOf obo:GO_0031012 . obo:GO_0062033 obo:IAO_0000115 "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2018-04-23T14:32:23Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062033" ; a owl:Class ; rdfs:label "positive regulation of mitotic sister chromatid segregation" ; rdfs:subClassOf obo:GO_0033047, obo:GO_0051984, obo:GO_2001252, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0000070 ] ) ] . obo:GO_0062125 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2019-05-30T16:45:04Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062125" ; a owl:Class ; rdfs:label "regulation of mitochondrial gene expression" ; rdfs:subClassOf obo:GO_0010468, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140053 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0140053 ] ) ] . obo:GO_0062149 obo:IAO_0000115 "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2019-09-13T13:48:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0062149" ; a owl:Class ; rdfs:label "detection of stimulus involved in sensory perception of pain" ; rdfs:subClassOf obo:GO_0050906, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019233 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0051606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_0065007 obo:IAO_0000115 "Any process that modulates a measurable attribute of any biological process, quality or function." ; oboInOwl:hasBroadSynonym "regulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0065007" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir ; a owl:Class ; rdfs:label "biological regulation" ; rdfs:subClassOf obo:GO_0008150 . obo:GO_0065008 obo:IAO_0000115 "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." ; oboInOwl:hasExactSynonym "regulation of biological attribute", "regulation of biological characteristic" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0065008" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "regulation of biological quality" ; rdfs:subClassOf obo:GO_0065007 . obo:GO_0065009 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." ; oboInOwl:hasExactSynonym "regulation of a molecular function" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0065009" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pir, go:goslim_plant ; a owl:Class ; rdfs:label "regulation of molecular function" ; rdfs:subClassOf obo:GO_0065007, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003674 ] ) ] . obo:GO_0065010 obo:IAO_0000115 "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." ; oboInOwl:hasExactSynonym "extracellular membrane-enclosed organelle" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0065010" ; a owl:Class ; rdfs:label "extracellular membrane-bounded organelle" ; rdfs:subClassOf obo:GO_0043227, obo:GO_0043230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0043227 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_0070013 obo:IAO_0000115 "An organelle lumen that is part of an intracellular organelle." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0070013" ; a owl:Class ; rdfs:label "intracellular organelle lumen" ; rdfs:subClassOf obo:GO_0043233, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043229 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031974 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043229 ] ) ] . obo:GO_0070085 obo:IAO_0000115 "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." ; oboInOwl:hasDbXref "Wikipedia:Glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070085" ; a owl:Class ; rdfs:label "glycosylation" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0070091 obo:IAO_0000115 "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070091" ; a owl:Class ; rdfs:label "glucagon secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0070092 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070092" ; a owl:Class ; rdfs:label "regulation of glucagon secretion" ; rdfs:subClassOf obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:GO_0070093 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." ; oboInOwl:hasExactSynonym "down regulation of glucagon secretion", "down-regulation of glucagon secretion", "downregulation of glucagon secretion" ; oboInOwl:hasNarrowSynonym "inhibition of glucagon secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070093" ; a owl:Class ; rdfs:label "negative regulation of glucagon secretion" ; rdfs:subClassOf obo:GO_0070092, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:GO_0070094 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." ; oboInOwl:hasExactSynonym "up regulation of glucagon secretion", "up-regulation of glucagon secretion", "upregulation of glucagon secretion" ; oboInOwl:hasNarrowSynonym "activation of glucagon secretion", "stimulation of glucagon secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070094" ; a owl:Class ; rdfs:label "positive regulation of glucagon secretion" ; rdfs:subClassOf obo:GO_0070092, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070091 ] ) ] . obo:GO_0070125 obo:IAO_0000115 "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." ; oboInOwl:hasExactSynonym "mitochondrial translation elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070125" ; a owl:Class ; rdfs:label "mitochondrial translational elongation" ; rdfs:subClassOf obo:GO_0006414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0032543 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0070129 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." ; oboInOwl:hasExactSynonym "regulation of mitochondrial protein anabolism", "regulation of mitochondrial protein biosynthesis", "regulation of mitochondrial protein formation", "regulation of mitochondrial protein synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070129" ; a owl:Class ; rdfs:label "regulation of mitochondrial translation" ; rdfs:subClassOf obo:GO_0006417, obo:GO_0062125, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032543 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032543 ] ) ] . obo:GO_0070130 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." ; oboInOwl:hasExactSynonym "negative regulation of mitochondrial protein anabolism", "negative regulation of mitochondrial protein biosynthesis", "negative regulation of mitochondrial protein formation", "negative regulation of mitochondrial protein synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070130" ; a owl:Class ; rdfs:label "negative regulation of mitochondrial translation" ; rdfs:subClassOf obo:GO_0017148, obo:GO_0070129, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032543 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032543 ] ) ] . obo:GO_0070131 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." ; oboInOwl:hasExactSynonym "positive regulation of mitochondrial protein anabolism", "positive regulation of mitochondrial protein biosynthesis", "positive regulation of mitochondrial protein formation", "positive regulation of mitochondrial protein synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070131" ; a owl:Class ; rdfs:label "positive regulation of mitochondrial translation" ; rdfs:subClassOf obo:GO_0045727, obo:GO_0070129, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032543 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032543 ] ) ] . obo:GO_0070161 obo:IAO_0000115 "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." ; oboInOwl:hasExactSynonym "anchoring cell junction" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0070161" ; a owl:Class ; rdfs:label "anchoring junction" ; rdfs:subClassOf obo:GO_0030054 . obo:GO_0070166 obo:IAO_0000115 "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "enamel formation" ; oboInOwl:id "GO:0070166" ; a owl:Class ; rdfs:label "enamel mineralization" ; rdfs:subClassOf obo:GO_0034505, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0097186 ] . obo:GO_0070167 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070167" ; a owl:Class ; rdfs:label "regulation of biomineral tissue development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031214 ] ) ] . obo:GO_0070168 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070168" ; a owl:Class ; rdfs:label "negative regulation of biomineral tissue development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0070167, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031214 ] ) ] . obo:GO_0070169 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070169" ; a owl:Class ; rdfs:label "positive regulation of biomineral tissue development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0070167, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031214 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031214 ] ) ] . obo:GO_0070170 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070170" ; a owl:Class ; rdfs:label "regulation of tooth mineralization" ; rdfs:subClassOf obo:GO_0070167, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0034505 ] ) ] . obo:GO_0070171 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070171" ; a owl:Class ; rdfs:label "negative regulation of tooth mineralization" ; rdfs:subClassOf obo:GO_0070168, obo:GO_0070170, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0034505 ] ) ] . obo:GO_0070172 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070172" ; a owl:Class ; rdfs:label "positive regulation of tooth mineralization" ; rdfs:subClassOf obo:GO_0070169, obo:GO_0070170, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0034505 ] ) ] . obo:GO_0070173 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070173" ; a owl:Class ; rdfs:label "regulation of enamel mineralization" ; rdfs:subClassOf obo:GO_0070170, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070166 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070166 ] ) ] . obo:GO_0070174 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070174" ; a owl:Class ; rdfs:label "negative regulation of enamel mineralization" ; rdfs:subClassOf obo:GO_0070171, obo:GO_0070173, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070166 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070166 ] ) ] . obo:GO_0070175 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070175" ; a owl:Class ; rdfs:label "positive regulation of enamel mineralization" ; rdfs:subClassOf obo:GO_0070172, obo:GO_0070173, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070166 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070166 ] ) ] . obo:GO_0070192 obo:IAO_0000115 "A process of chromosome organization that is involved in a meiotic cell cycle." ; oboInOwl:hasExactSynonym "chromosome organisation involved in meiosis", "meiotic chromosome organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070192" ; a owl:Class ; rdfs:label "chromosome organization involved in meiotic cell cycle" ; rdfs:subClassOf obo:GO_0051276, obo:GO_1903046 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0051276 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0070201 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." ; oboInOwl:hasExactSynonym "regulation of establishment of protein localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070201" ; a owl:Class ; rdfs:label "regulation of establishment of protein localization" ; rdfs:subClassOf obo:GO_0032880, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045184 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0045184 ] ) ] . obo:GO_0070227 obo:IAO_0000115 "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ; oboInOwl:hasNarrowSynonym "lymphocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070227" ; a owl:Class ; rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ; rdfs:label "lymphocyte apoptotic process" ; rdfs:subClassOf obo:GO_0071887 . obo:GO_0070228 obo:IAO_0000115 "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." ; oboInOwl:hasNarrowSynonym "regulation of lymphocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070228" ; a owl:Class ; rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ; rdfs:label "regulation of lymphocyte apoptotic process" ; rdfs:subClassOf obo:GO_2000106, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070227 ] ) ] . obo:GO_0070229 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." ; oboInOwl:hasExactSynonym "down regulation of lymphocyte apoptosis", "down-regulation of lymphocyte apoptosis", "downregulation of lymphocyte apoptosis" ; oboInOwl:hasNarrowSynonym "inhibition of lymphocyte apoptosis", "negative regulation of lymphocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070229" ; a owl:Class ; rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ; rdfs:label "negative regulation of lymphocyte apoptotic process" ; rdfs:subClassOf obo:GO_0070228, obo:GO_2000107, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070227 ] ) ] . obo:GO_0070230 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." ; oboInOwl:hasExactSynonym "up regulation of lymphocyte apoptosis", "up-regulation of lymphocyte apoptosis", "upregulation of lymphocyte apoptosis" ; oboInOwl:hasNarrowSynonym "activation of lymphocyte apoptosis", "positive regulation of lymphocyte apoptosis", "stimulation of lymphocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070230" ; a owl:Class ; rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ; rdfs:label "positive regulation of lymphocyte apoptotic process" ; rdfs:subClassOf obo:GO_0070228, obo:GO_2000108, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070227 ] ) ] . obo:GO_0070253 obo:IAO_0000115 "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070253" ; a owl:Class ; rdfs:label "somatostatin secretion" ; rdfs:subClassOf obo:GO_0030072 . obo:GO_0070254 obo:IAO_0000115 "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." ; oboInOwl:hasExactSynonym "mucus production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070254" ; a owl:Class ; rdfs:label "mucus secretion" ; rdfs:subClassOf obo:GO_0007589, obo:GO_0032941 . obo:GO_0070255 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." ; oboInOwl:hasExactSynonym "regulation of mucus production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070255" ; a owl:Class ; rdfs:label "regulation of mucus secretion" ; rdfs:subClassOf obo:GO_0050878, obo:GO_0051046, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:GO_0070256 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." ; oboInOwl:hasExactSynonym "negative regulation of mucus production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070256" ; a owl:Class ; rdfs:label "negative regulation of mucus secretion" ; rdfs:subClassOf obo:GO_0051048, obo:GO_0051241, obo:GO_0070255, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:GO_0070257 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." ; oboInOwl:hasExactSynonym "positive regulation of mucus production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070257" ; a owl:Class ; rdfs:label "positive regulation of mucus secretion" ; rdfs:subClassOf obo:GO_0051047, obo:GO_0051240, obo:GO_0070255, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070254 ] ) ] . obo:GO_0070278 obo:IAO_0000115 "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." ; oboInOwl:hasExactSynonym "ECM constituent secretion", "ECM secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070278" ; a owl:Class ; rdfs:label "extracellular matrix constituent secretion" ; rdfs:subClassOf obo:GO_0032940, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030198 ] . obo:GO_0070288 obo:IAO_0000115 "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0070288" ; a owl:Class ; rdfs:label "ferritin complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_0070293 obo:IAO_0000115 "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." ; oboInOwl:hasExactSynonym "nephron absorption", "renal reabsorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070293" ; a owl:Class ; rdfs:label "renal absorption" ; rdfs:subClassOf obo:GO_0003014 . obo:GO_0070295 obo:IAO_0000115 "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." ; oboInOwl:hasExactSynonym "nephron water absorption", "renal water reabsorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070295" ; a owl:Class ; rdfs:label "renal water absorption" ; rdfs:subClassOf obo:GO_0003097, obo:GO_0070293 . obo:GO_0070451 obo:IAO_0000115 "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." ; oboInOwl:hasDbXref "Wikipedia:Membrane_nanotube" ; oboInOwl:hasExactSynonym "non-sensory hair" ; oboInOwl:hasNarrowSynonym "imaginal disc-derived wing hair" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0070451" ; a owl:Class ; rdfs:label "cell hair" ; rdfs:subClassOf obo:GO_0120025 . obo:GO_0070453 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." ; oboInOwl:hasExactSynonym "regulation of haem biosynthesis", "regulation of haem biosynthetic process", "regulation of heme anabolism", "regulation of heme biosynthesis", "regulation of heme formation", "regulation of heme synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070453" ; a owl:Class ; rdfs:label "regulation of heme biosynthetic process" ; rdfs:subClassOf obo:GO_1901463, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006783 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006783 ] ) ] . obo:GO_0070454 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." ; oboInOwl:hasExactSynonym "down regulation of heme biosynthetic process", "down-regulation of heme biosynthetic process", "downregulation of heme biosynthetic process", "negative regulation of haem biosynthetic process", "negative regulation of heme anabolism", "negative regulation of heme biosynthesis", "negative regulation of heme formation", "negative regulation of heme synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of heme biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070454" ; a owl:Class ; rdfs:label "negative regulation of heme biosynthetic process" ; rdfs:subClassOf obo:GO_0070453, obo:GO_1901464, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006783 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006783 ] ) ] . obo:GO_0070455 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." ; oboInOwl:hasExactSynonym "positive regulation of haem biosynthetic process", "positive regulation of heme anabolism", "positive regulation of heme biosynthesis", "positive regulation of heme formation", "positive regulation of heme synthesis", "up regulation of heme biosynthetic process", "up-regulation of heme biosynthetic process", "upregulation of heme biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of heme biosynthetic process", "stimulation of heme biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070455" ; a owl:Class ; rdfs:label "positive regulation of heme biosynthetic process" ; rdfs:subClassOf obo:GO_0070453, obo:GO_1901465, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006783 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006783 ] ) ] . obo:GO_0070459 obo:IAO_0000115 "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070459" ; a owl:Class ; rdfs:label "prolactin secretion" ; rdfs:subClassOf obo:GO_0009306, obo:GO_0030072 . obo:GO_0070469 obo:IAO_0000115 "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/12846"^^xsd:anyURI ; oboInOwl:hasExactSynonym "membrane electron transport chain", "respiratory chain" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0070469" ; a owl:Class ; rdfs:label "respirasome" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016020 ] . obo:GO_0070507 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." ; oboInOwl:hasExactSynonym "regulation of microtubule cytoskeleton organisation", "regulation of microtubule dynamics" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070507" ; a owl:Class ; rdfs:label "regulation of microtubule cytoskeleton organization" ; rdfs:subClassOf obo:GO_0032886, obo:GO_0051493, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000226 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0000226 ] ) ] . obo:GO_0070527 obo:IAO_0000115 "The adhesion of one platelet to one or more other platelets via adhesion molecules." ; oboInOwl:hasExactSynonym "blood platelet aggregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "thrombocyte aggregation" ; oboInOwl:id "GO:0070527" ; a owl:Class ; rdfs:label "platelet aggregation" ; rdfs:subClassOf obo:GO_0034109, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030168 ] . obo:GO_0070613 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-04-29T02:49:14Z" ; oboInOwl:hasAlternativeId "GO:0010953" ; oboInOwl:hasExactSynonym "regulation of protein maturation by peptide bond cleavage" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070613" ; a owl:Class ; rdfs:label "regulation of protein processing" ; rdfs:subClassOf obo:GO_0030162, obo:GO_1903317, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:GO_0070661 obo:IAO_0000115 "The expansion of a leukocyte population by cell division." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-05-28T05:25:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070661" ; a owl:Class ; rdfs:label "leukocyte proliferation" ; rdfs:subClassOf obo:GO_0008283 . obo:GO_0070663 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of leukocyte proliferation." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-05-28T05:30:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070663" ; a owl:Class ; rdfs:label "regulation of leukocyte proliferation" ; rdfs:subClassOf obo:GO_0042127, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070661 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070661 ] ) ] . obo:GO_0070664 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-05-28T05:34:50Z" ; oboInOwl:hasExactSynonym "down regulation of leukocyte proliferation", "down-regulation of leukocyte proliferation", "downregulation of leukocyte proliferation" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070664" ; a owl:Class ; rdfs:label "negative regulation of leukocyte proliferation" ; rdfs:subClassOf obo:GO_0008285, obo:GO_0070663, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070661 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070661 ] ) ] . obo:GO_0070665 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-05-28T05:36:46Z" ; oboInOwl:hasExactSynonym "up regulation of leukocyte proliferation", "up-regulation of leukocyte proliferation", "upregulation of leukocyte proliferation" ; oboInOwl:hasNarrowSynonym "activation of leukocyte proliferation", "stimulation of leukocyte proliferation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070665" ; a owl:Class ; rdfs:label "positive regulation of leukocyte proliferation" ; rdfs:subClassOf obo:GO_0008284, obo:GO_0070663, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070661 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070661 ] ) ] . obo:GO_0070727 obo:IAO_0000115 "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-06-16T04:08:29Z" ; oboInOwl:hasExactSynonym "cellular macromolecule localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070727" ; a owl:Class ; rdfs:label "cellular macromolecule localization" ; rdfs:subClassOf obo:GO_0033036, obo:GO_0051641 . obo:GO_0070857 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-14T03:09:02Z" ; oboInOwl:hasExactSynonym "regulation of bile acid anabolism", "regulation of bile acid biosynthesis", "regulation of bile acid formation", "regulation of bile acid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070857" ; a owl:Class ; rdfs:label "regulation of bile acid biosynthetic process" ; rdfs:subClassOf obo:GO_0010565, obo:GO_0031326, obo:GO_0050810, obo:GO_1904251, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006699 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006699 ] ) ] . obo:GO_0070858 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-14T03:16:40Z" ; oboInOwl:hasExactSynonym "down regulation of bile acid biosynthetic process", "down-regulation of bile acid biosynthetic process", "downregulation of bile acid biosynthetic process", "negative regulation of bile acid anabolism", "negative regulation of bile acid biosynthesis", "negative regulation of bile acid formation", "negative regulation of bile acid synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of bile acid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070858" ; a owl:Class ; rdfs:label "negative regulation of bile acid biosynthetic process" ; rdfs:subClassOf obo:GO_0010894, obo:GO_0031327, obo:GO_0070857, obo:GO_1904252, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006699 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006699 ] ) ] . obo:GO_0070859 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-14T03:22:58Z" ; oboInOwl:hasExactSynonym "positive regulation of bile acid anabolism", "positive regulation of bile acid biosynthesis", "positive regulation of bile acid formation", "positive regulation of bile acid synthesis", "up regulation of bile acid biosynthetic process", "up-regulation of bile acid biosynthetic process", "upregulation of bile acid biosynthetic process" ; oboInOwl:hasNarrowSynonym "activation of bile acid biosynthetic process", "stimulation of bile acid biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070859" ; a owl:Class ; rdfs:label "positive regulation of bile acid biosynthetic process" ; rdfs:subClassOf obo:GO_0010893, obo:GO_0031328, obo:GO_0070857, obo:GO_1904253, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006699 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006699 ] ) ] . obo:GO_0070873 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-20T02:44:53Z" ; oboInOwl:hasExactSynonym "regulation of glycogen metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070873" ; a owl:Class ; rdfs:label "regulation of glycogen metabolic process" ; rdfs:subClassOf obo:GO_0032881, obo:GO_0043467, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0005977 ] ) ] . obo:GO_0070874 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-20T02:50:41Z" ; oboInOwl:hasExactSynonym "negative regulation of glycogen metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070874" ; a owl:Class ; rdfs:label "negative regulation of glycogen metabolic process" ; rdfs:subClassOf obo:GO_0010605, obo:GO_0031324, obo:GO_0045912, obo:GO_0070873, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0005977 ] ) ] . obo:GO_0070875 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-20T02:53:55Z" ; oboInOwl:hasExactSynonym "positive regulation of glycogen metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070875" ; a owl:Class ; rdfs:label "positive regulation of glycogen metabolic process" ; rdfs:subClassOf obo:GO_0010604, obo:GO_0010907, obo:GO_0031325, obo:GO_0070873, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0005977 ] ) ] . obo:GO_0070887 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-08-27T04:41:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070887" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "cellular response to chemical stimulus" ; rdfs:subClassOf obo:GO_0042221, obo:GO_0051716 . obo:GO_0070925 obo:IAO_0000115 "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-09-15T03:00:51Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070925" ; oboInOwl:inSubset go:goslim_yeast ; a owl:Class ; rdfs:label "organelle assembly" ; rdfs:subClassOf obo:GO_0006996, obo:GO_0022607 . obo:GO_0070942 obo:IAO_0000115 "The directed killing of a target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T01:49:30Z" ; oboInOwl:hasExactSynonym "neutrophil mediated cell killing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070942" ; a owl:Class ; rdfs:label "neutrophil mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001909, obo:GO_0002446 . obo:GO_0070943 obo:IAO_0000115 "The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T01:52:03Z" ; oboInOwl:hasExactSynonym "neutrophil mediated killing of symbiont cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070943" ; a owl:Class ; rdfs:label "neutrophil-mediated killing of symbiont cell" ; rdfs:subClassOf obo:GO_0051873, obo:GO_0070942 . obo:GO_0070944 obo:IAO_0000115 "The directed killing of a bacterium by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T01:55:56Z" ; oboInOwl:hasExactSynonym "neutrophil mediated killing of bacterium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070944" ; a owl:Class ; rdfs:label "neutrophil-mediated killing of bacterium" ; rdfs:subClassOf obo:GO_0070943, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0042742 ] . obo:GO_0070948 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:14:36Z" ; oboInOwl:hasExactSynonym "regulation of neutrophil mediated cell killing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070948" ; a owl:Class ; rdfs:label "regulation of neutrophil mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001910, obo:GO_0002886, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070942 ] ) ] . obo:GO_0070949 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:14:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070949" ; a owl:Class ; rdfs:label "regulation of neutrophil mediated killing of symbiont cell" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0031347, obo:GO_0032101, obo:GO_0043903, obo:GO_0051709, obo:GO_0070948, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070943 ] ) ] . obo:GO_0070950 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:14:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070950" ; a owl:Class ; rdfs:label "regulation of neutrophil mediated killing of bacterium" ; rdfs:subClassOf obo:GO_0070949, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070944 ] ) ] . obo:GO_0070954 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:20:17Z" ; oboInOwl:hasExactSynonym "down regulation of neutrophil mediated cytotoxicity", "down-regulation of neutrophil mediated cytotoxicity", "downregulation of neutrophil mediated cytotoxicity", "negative regulation of neutrophil mediated cell killing" ; oboInOwl:hasNarrowSynonym "inhibition of neutrophil mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070954" ; a owl:Class ; rdfs:label "negative regulation of neutrophil mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001911, obo:GO_0002887, obo:GO_0070948, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070942 ] ) ] . obo:GO_0070955 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:20:17Z" ; oboInOwl:hasExactSynonym "down regulation of neutrophil mediated killing of symbiont cell", "down-regulation of neutrophil mediated killing of symbiont cell", "downregulation of neutrophil mediated killing of symbiont cell" ; oboInOwl:hasNarrowSynonym "inhibition of neutrophil mediated killing of symbiont cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070955" ; a owl:Class ; rdfs:label "negative regulation of neutrophil mediated killing of symbiont cell" ; rdfs:subClassOf obo:GO_0002832, obo:GO_0031348, obo:GO_0032102, obo:GO_0051711, obo:GO_0070949, obo:GO_0070954, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070943 ] ) ] . obo:GO_0070956 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:20:17Z" ; oboInOwl:hasExactSynonym "down regulation of neutrophil mediated killing of bacterium", "down-regulation of neutrophil mediated killing of bacterium", "downregulation of neutrophil mediated killing of bacterium" ; oboInOwl:hasNarrowSynonym "inhibition of neutrophil mediated killing of bacterium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070956" ; a owl:Class ; rdfs:label "negative regulation of neutrophil mediated killing of bacterium" ; rdfs:subClassOf obo:GO_0070950, obo:GO_0070955, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070944 ] ) ] . obo:GO_0070960 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:28:49Z" ; oboInOwl:hasExactSynonym "positive regulation of neutrophil mediated cell killing", "up regulation of neutrophil mediated cytotoxicity", "up-regulation of neutrophil mediated cytotoxicity", "upregulation of neutrophil mediated cytotoxicity" ; oboInOwl:hasNarrowSynonym "activation of neutrophil mediated cytotoxicity", "stimulation of neutrophil mediated cytotoxicity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070960" ; a owl:Class ; rdfs:label "positive regulation of neutrophil mediated cytotoxicity" ; rdfs:subClassOf obo:GO_0001912, obo:GO_0002888, obo:GO_0070948, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070942 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070942 ] ) ] . obo:GO_0070961 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:28:49Z" ; oboInOwl:hasExactSynonym "up regulation of neutrophil mediated killing of symbiont cell", "up-regulation of neutrophil mediated killing of symbiont cell", "upregulation of neutrophil mediated killing of symbiont cell" ; oboInOwl:hasNarrowSynonym "activation of neutrophil mediated killing of symbiont cell", "stimulation of neutrophil mediated killing of symbiont cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070961" ; a owl:Class ; rdfs:label "positive regulation of neutrophil mediated killing of symbiont cell" ; rdfs:subClassOf obo:GO_0002833, obo:GO_0031349, obo:GO_0032103, obo:GO_0051712, obo:GO_0070949, obo:GO_0070960, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070943 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070943 ] ) ] . obo:GO_0070962 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-01T02:28:49Z" ; oboInOwl:hasExactSynonym "up regulation of neutrophil mediated killing of bacterium", "up-regulation of neutrophil mediated killing of bacterium", "upregulation of neutrophil mediated killing of bacterium" ; oboInOwl:hasNarrowSynonym "activation of neutrophil mediated killing of bacterium", "stimulation of neutrophil mediated killing of bacterium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070962" ; a owl:Class ; rdfs:label "positive regulation of neutrophil mediated killing of bacterium" ; rdfs:subClassOf obo:GO_0070950, obo:GO_0070961, obo:GO_1900426, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070944 ] ) ] . obo:GO_0070977 obo:IAO_0000115 "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-10-05T04:35:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0070977" ; a owl:Class ; rdfs:label "bone maturation" ; rdfs:subClassOf obo:GO_0048799, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060348 ] . obo:GO_0071310 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-12-10T04:46:04Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071310" ; a owl:Class ; rdfs:label "cellular response to organic substance" ; rdfs:subClassOf obo:GO_0010033, obo:GO_0070887 . obo:GO_0071345 obo:IAO_0000115 "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2009-12-11T02:41:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071345" ; a owl:Class ; rdfs:label "cellular response to cytokine stimulus" ; rdfs:subClassOf obo:GO_0034097, obo:GO_0071310 . obo:GO_0071621 obo:IAO_0000115 "The movement of a granulocyte in response to an external stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-09T04:08:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071621" ; a owl:Class ; rdfs:label "granulocyte chemotaxis" ; rdfs:subClassOf obo:GO_0030595, obo:GO_0097530 . obo:GO_0071622 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-09T04:09:24Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071622" ; a owl:Class ; rdfs:label "regulation of granulocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002688, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071621 ] ) ] . obo:GO_0071623 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-09T04:13:19Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071623" ; a owl:Class ; rdfs:label "negative regulation of granulocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002689, obo:GO_0071622, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071621 ] ) ] . obo:GO_0071624 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-09T04:15:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071624" ; a owl:Class ; rdfs:label "positive regulation of granulocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002690, obo:GO_0071622, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071621 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071621 ] ) ] . obo:GO_0071625 obo:IAO_0000115 "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-10T11:02:58Z" ; oboInOwl:hasExactSynonym "vocalisation behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071625" ; a owl:Class ; rdfs:label "vocalization behavior" ; rdfs:subClassOf obo:GO_0007610 . obo:GO_0071626 obo:IAO_0000115 "The process of biting and mashing food with the teeth prior to swallowing." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-10T11:19:48Z" ; oboInOwl:hasExactSynonym "chewing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071626" ; a owl:Class ; rdfs:label "mastication" ; rdfs:subClassOf obo:GO_0022600 . obo:GO_0071674 obo:IAO_0000115 "The movement of a mononuclear cell within or between different tissues and organs of the body." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-16T02:11:00Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071674" ; a owl:Class ; rdfs:label "mononuclear cell migration" ; rdfs:subClassOf obo:GO_0050900 . obo:GO_0071675 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-16T02:11:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071675" ; a owl:Class ; rdfs:label "regulation of mononuclear cell migration" ; rdfs:subClassOf obo:GO_0002685, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071674 ] ) ] . obo:GO_0071676 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-16T02:13:55Z" ; oboInOwl:hasExactSynonym "down regulation of mononuclear cell migration", "down-regulation of mononuclear cell migration", "downregulation of mononuclear cell migration" ; oboInOwl:hasNarrowSynonym "inhibition of mononuclear cell migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071676" ; a owl:Class ; rdfs:label "negative regulation of mononuclear cell migration" ; rdfs:subClassOf obo:GO_0002686, obo:GO_0071675, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071674 ] ) ] . obo:GO_0071677 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-16T02:15:29Z" ; oboInOwl:hasExactSynonym "up regulation of mononuclear cell migration", "up-regulation of mononuclear cell migration", "upregulation of mononuclear cell migration" ; oboInOwl:hasNarrowSynonym "activation of mononuclear cell migration", "stimulation of mononuclear cell migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071677" ; a owl:Class ; rdfs:label "positive regulation of mononuclear cell migration" ; rdfs:subClassOf obo:GO_0002687, obo:GO_0071675, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071674 ] ) ] . obo:GO_0071692 obo:IAO_0000115 "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-25T04:00:13Z" ; oboInOwl:hasExactSynonym "protein localisation in extracellular region", "protein localization in extracellular region" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071692" ; a owl:Class ; rdfs:label "protein localization to extracellular region" ; rdfs:subClassOf obo:GO_0008104 . obo:GO_0071695 obo:IAO_0000115 "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-02T11:43:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071695" ; a owl:Class ; rdfs:label "anatomical structure maturation" ; rdfs:subClassOf obo:GO_0021700, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048856 ] . obo:GO_0071702 obo:IAO_0000115 "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-08T02:15:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071702" ; a owl:Class ; rdfs:label "organic substance transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0071704 obo:IAO_0000115 "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-08T03:32:18Z" ; oboInOwl:hasExactSynonym "organic molecular entity metabolic process", "organic molecular entity metabolism", "organic substance metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071704" ; a owl:Class ; rdfs:label "organic substance metabolic process" ; rdfs:subClassOf obo:GO_0008152 . obo:GO_0071705 obo:IAO_0000115 "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-08T03:56:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071705" ; a owl:Class ; rdfs:label "nitrogen compound transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0071707 obo:IAO_0000115 "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-09T04:20:31Z" ; oboInOwl:hasBroadSynonym "immunoglobulin V(D)J joining", "immunoglobulin V(D)J recombination" ; oboInOwl:hasExactSynonym "immunoglobulin V-D-J joining" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071707" ; a owl:Class ; rdfs:label "immunoglobulin heavy chain V-D-J recombination" ; rdfs:subClassOf obo:GO_0033152 . obo:GO_0071708 obo:IAO_0000115 "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-09T04:22:29Z" ; oboInOwl:hasBroadSynonym "immunoglobulin V(D)J joining", "immunoglobulin V(D)J recombination" ; oboInOwl:hasExactSynonym "immunoglobulin V-J joining" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071708" ; a owl:Class ; rdfs:label "immunoglobulin light chain V-J recombination" ; rdfs:subClassOf obo:GO_0033152 . obo:GO_0071735 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasNarrowSynonym "IgG1", "IgG2", "IgG2a", "IgG2b", "IgG2c", "IgG3", "IgG4" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071735" ; a owl:Class ; rdfs:comment "Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species." ; rdfs:label "IgG immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071736 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasNarrowSynonym "IgG antibody", "IgG1 antibody", "IgG2 antibody", "IgG2a antibody", "IgG2b antibody", "IgG2c antibody", "IgG3 antibody", "IgG4 antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071736" ; a owl:Class ; rdfs:comment "Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species." ; rdfs:label "IgG immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0042571, obo:GO_0071735 . obo:GO_0071738 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071738" ; a owl:Class ; rdfs:comment "Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgD immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071739 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasExactSynonym "IgD antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071739" ; a owl:Class ; rdfs:comment "Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgD immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0042571, obo:GO_0071738 . obo:GO_0071742 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071742" ; a owl:Class ; rdfs:comment "Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgE immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071743 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasExactSynonym "IgE antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071743" ; a owl:Class ; rdfs:comment "Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgE immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0042571, obo:GO_0071742 . obo:GO_0071745 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasNarrowSynonym "IgA1 antibody", "IgA2 antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071745" ; a owl:Class ; rdfs:comment "Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgA immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071746 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasExactSynonym "IgA antibody" ; oboInOwl:hasNarrowSynonym "IgA1 antibody", "IgA2 antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071746" ; a owl:Class ; rdfs:comment "Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgA immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0042571, obo:GO_0071745 . obo:GO_0071753 obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071753" ; a owl:Class ; rdfs:comment "Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgM immunoglobulin complex" ; rdfs:subClassOf obo:GO_0019814 . obo:GO_0071754 obo:IAO_0000115 "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-24T01:44:53Z" ; oboInOwl:hasExactSynonym "IgM antibody" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071754" ; a owl:Class ; rdfs:comment "Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available." ; rdfs:label "IgM immunoglobulin complex, circulating" ; rdfs:subClassOf obo:GO_0042571, obo:GO_0071753 . obo:GO_0071824 obo:IAO_0000115 "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-08T10:03:26Z" ; oboInOwl:hasExactSynonym "DNA-protein complex subunit organization", "protein-DNA complex subunit organisation", "protein-DNA complex subunit organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071824" ; a owl:Class ; rdfs:label "protein-DNA complex organization" ; rdfs:subClassOf obo:GO_0043933 . obo:GO_0071840 obo:IAO_0000115 "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-10T01:39:16Z" ; oboInOwl:hasAlternativeId "GO:0071841" ; oboInOwl:hasExactSynonym "cellular component organisation or biogenesis", "cellular component organisation or biogenesis at cellular level", "cellular component organization or biogenesis at cellular level" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071840" ; oboInOwl:inSubset go:goslim_flybase_ribbon, go:goslim_metagenomics ; a owl:Class ; rdfs:label "cellular component organization or biogenesis" ; rdfs:subClassOf obo:GO_0009987 . obo:GO_0071887 obo:IAO_0000115 "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-14T12:44:09Z" ; oboInOwl:hasNarrowSynonym "leukocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071887" ; a owl:Class ; rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ; rdfs:label "leukocyte apoptotic process" ; rdfs:subClassOf obo:GO_0006915 . obo:GO_0071944 obo:IAO_0000115 "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-04T01:51:47Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071944" ; oboInOwl:inSubset go:goslim_flybase_ribbon ; a owl:Class ; rdfs:label "cell periphery" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0071953 obo:IAO_0000115 "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-11T11:44:57Z" ; oboInOwl:hasExactSynonym "elastic fibre", "elastin fiber" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0071953" ; a owl:Class ; rdfs:label "elastic fiber" ; rdfs:subClassOf obo:GO_0099512, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0031012 ] . obo:GO_0071971 obo:IAO_0000115 "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-18T03:44:18Z" ; oboInOwl:hasExactSynonym "extracellular vesicular exosome assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0071971" ; a owl:Class ; rdfs:label "extracellular exosome assembly" ; rdfs:subClassOf obo:GO_0016050, obo:GO_0070925, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0097734 ] . obo:GO_0072175 obo:IAO_0000115 "The developmental process pertaining to the initial formation of an epithelial tube." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22302"^^xsd:anyURI ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-02-26T02:15:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072175" ; a owl:Class ; rdfs:label "epithelial tube formation" ; rdfs:subClassOf obo:GO_0035148, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060562 ] . obo:GO_0072201 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-03-01T03:43:29Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072201" ; a owl:Class ; rdfs:label "negative regulation of mesenchymal cell proliferation" ; rdfs:subClassOf obo:GO_0008285, obo:GO_0010464, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010463 ] ) ] . obo:GO_0072330 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-02T04:51:32Z" ; oboInOwl:hasExactSynonym "monocarboxylic acid anabolism", "monocarboxylic acid biosynthesis", "monocarboxylic acid formation", "monocarboxylic acid synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072330" ; a owl:Class ; rdfs:label "monocarboxylic acid biosynthetic process" ; rdfs:subClassOf obo:GO_0032787, obo:GO_0046394 . obo:GO_0072350 obo:IAO_0000115 "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-11T05:07:30Z" ; oboInOwl:hasExactSynonym "tricarboxylic acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072350" ; a owl:Class ; rdfs:label "tricarboxylic acid metabolic process" ; rdfs:subClassOf obo:GO_0019752 . obo:GO_0072359 obo:IAO_0000115 "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-16T11:27:39Z" ; oboInOwl:hasAlternativeId "GO:0072358" ; oboInOwl:hasNarrowSynonym "cardiovascular system development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072359" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "circulatory system development" ; rdfs:subClassOf obo:GO_0048731 . obo:GO_0072376 obo:IAO_0000115 "A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/23378"^^xsd:anyURI ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-22T02:54:18Z" ; oboInOwl:hasExactSynonym "protein activation pathway", "protein activitory cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072376" ; a owl:Class ; rdfs:label "protein activation cascade" ; rdfs:subClassOf obo:GO_0051604 . obo:GO_0072377 obo:IAO_0000115 "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-22T03:01:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072377" ; a owl:Class ; rdfs:comment "See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'." ; rdfs:label "blood coagulation, common pathway" ; rdfs:subClassOf obo:GO_0072376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0072378 ] . obo:GO_0072378 obo:IAO_0000115 "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-22T03:09:32Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072378" ; a owl:Class ; rdfs:comment "See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'." ; rdfs:label "blood coagulation, fibrin clot formation" ; rdfs:subClassOf obo:GO_0072376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007596 ] . obo:GO_0072507 obo:IAO_0000115 "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." ; obo:IAO_0100001 "GO:0055080" ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-12-16T03:22:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072507" ; a owl:Class ; rdfs:comment "This term was obsoleted because it is an unnecessary grouping class." ; rdfs:label "obsolete divalent inorganic cation homeostasis" ; owl:deprecated true . obo:GO_0072521 obo:IAO_0000115 "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-01-04T03:03:59Z" ; oboInOwl:hasExactSynonym "purine and derivative metabolic process", "purine-containing compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072521" ; a owl:Class ; rdfs:label "purine-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0006725, obo:GO_0034641, obo:GO_0046483, obo:GO_1901360, obo:GO_1901564 . obo:GO_0072527 obo:IAO_0000115 "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-01-04T03:27:19Z" ; oboInOwl:hasExactSynonym "pyrimidine and derivative metabolic process", "pyrimidine-containing compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072527" ; a owl:Class ; rdfs:label "pyrimidine-containing compound metabolic process" ; rdfs:subClassOf obo:GO_0034641, obo:GO_0046483, obo:GO_1901360, obo:GO_1901564 . obo:GO_0072593 obo:IAO_0000115 "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-02-11T10:50:06Z" ; oboInOwl:hasExactSynonym "ROS metabolic process", "reactive oxygen species metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0072593" ; a owl:Class ; rdfs:label "reactive oxygen species metabolic process" ; rdfs:subClassOf obo:GO_0044237 . obo:GO_0080090 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2009-04-22T04:30:52Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0080090" ; a owl:Class ; rdfs:label "regulation of primary metabolic process" ; rdfs:subClassOf obo:GO_0019222, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044238 ] ) ] . obo:GO_0080134 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2009-05-06T04:51:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0080134" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "regulation of response to stress" ; rdfs:subClassOf obo:GO_0048583, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006950 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006950 ] ) ] . obo:GO_0080135 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2009-05-06T05:02:52Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0080135" ; a owl:Class ; rdfs:label "regulation of cellular response to stress" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0080134, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033554 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033554 ] ) ] . obo:GO_0080154 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2010-09-01T03:44:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0080154" ; a owl:Class ; rdfs:label "regulation of fertilization" ; rdfs:subClassOf obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:GO_0086103 obo:IAO_0000115 "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-03-19T01:28:23Z" ; oboInOwl:hasExactSynonym "G-protein coupled receptor signaling pathway involved in heart process", "G-protein coupled receptor signalling pathway involved in heart process", "GPCR signaling pathway involved in cardiac process", "GPCR signaling pathway involved in heart process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0086103" ; a owl:Class ; rdfs:label "G protein-coupled receptor signaling pathway involved in heart process" ; rdfs:subClassOf obo:GO_0007186, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0003015 ] ) ] . obo:GO_0090022 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:09:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090022" ; a owl:Class ; rdfs:label "regulation of neutrophil chemotaxis" ; rdfs:subClassOf obo:GO_0071622, obo:GO_1902622, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030593 ] ) ] . obo:GO_0090023 obo:IAO_0000115 "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:12:23Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090023" ; a owl:Class ; rdfs:label "positive regulation of neutrophil chemotaxis" ; rdfs:subClassOf obo:GO_0071624, obo:GO_0090022, obo:GO_1902624, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030593 ] ) ] . obo:GO_0090024 obo:IAO_0000115 "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:13:09Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090024" ; a owl:Class ; rdfs:label "negative regulation of neutrophil chemotaxis" ; rdfs:subClassOf obo:GO_0071623, obo:GO_0090022, obo:GO_1902623, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030593 ] ) ] . obo:GO_0090025 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:17:03Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090025" ; a owl:Class ; rdfs:label "regulation of monocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002688, obo:GO_0071675, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002548 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002548 ] ) ] . obo:GO_0090026 obo:IAO_0000115 "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:18:54Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090026" ; a owl:Class ; rdfs:label "positive regulation of monocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002690, obo:GO_0071677, obo:GO_0090025, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002548 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002548 ] ) ] . obo:GO_0090027 obo:IAO_0000115 "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:19:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090027" ; a owl:Class ; rdfs:label "negative regulation of monocyte chemotaxis" ; rdfs:subClassOf obo:GO_0002689, obo:GO_0071676, obo:GO_0090025, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002548 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002548 ] ) ] . obo:GO_0090030 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:38:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090030" ; a owl:Class ; rdfs:label "regulation of steroid hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0046885, obo:GO_0050810 . obo:GO_0090031 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:40:32Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090031" ; a owl:Class ; rdfs:label "positive regulation of steroid hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0010893, obo:GO_0046886, obo:GO_0090030 . obo:GO_0090032 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-08-03T10:41:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090032" ; a owl:Class ; rdfs:label "negative regulation of steroid hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0010894, obo:GO_0032353, obo:GO_0090030 . obo:GO_0090068 obo:IAO_0000115 "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-09-09T11:39:52Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090068" ; a owl:Class ; rdfs:label "positive regulation of cell cycle process" ; rdfs:subClassOf obo:GO_0010564, obo:GO_0045787, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022402 ] ) ] . obo:GO_0090087 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-10-23T11:21:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090087" ; a owl:Class ; rdfs:label "regulation of peptide transport" ; rdfs:subClassOf obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015833 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0015833 ] ) ] . obo:GO_0090139 obo:IAO_0000115 "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-08T02:12:19Z" ; oboInOwl:hasExactSynonym "mitochondrial DNA packaging" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090139" ; a owl:Class ; rdfs:label "mitochondrial chromosome packaging" ; rdfs:subClassOf obo:GO_0051276, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0051276 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0090174 obo:IAO_0000115 "The joining of two lipid bilayers to form a single organelle membrane." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-11T11:44:58Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090174" ; a owl:Class ; rdfs:label "organelle membrane fusion" ; rdfs:subClassOf obo:GO_0048284, obo:GO_0061025 . obo:GO_0090181 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-18T10:33:49Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090181" ; a owl:Class ; rdfs:label "regulation of cholesterol metabolic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008203 ] ) ] . obo:GO_0090205 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-23T10:27:37Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090205" ; a owl:Class ; rdfs:label "positive regulation of cholesterol metabolic process" ; rdfs:subClassOf obo:GO_0045940, obo:GO_0062013, obo:GO_0090181, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008203 ] ) ] . obo:GO_0090206 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2009-12-23T10:27:37Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090206" ; a owl:Class ; rdfs:label "negative regulation of cholesterol metabolic process" ; rdfs:subClassOf obo:GO_0045939, obo:GO_0062014, obo:GO_0090181, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008203 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008203 ] ) ] . obo:GO_0090257 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-03T11:48:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090257" ; a owl:Class ; rdfs:label "regulation of muscle system process" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003012 ] ) ] . obo:GO_0090273 obo:IAO_0000115 "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:54:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090273" ; a owl:Class ; rdfs:label "regulation of somatostatin secretion" ; rdfs:subClassOf obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070253 ] ) ] . obo:GO_0090274 obo:IAO_0000115 "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:54:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090274" ; a owl:Class ; rdfs:label "positive regulation of somatostatin secretion" ; rdfs:subClassOf obo:GO_0090273, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070253 ] ) ] . obo:GO_0090275 obo:IAO_0000115 "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:54:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090275" ; a owl:Class ; rdfs:label "negative regulation of somatostatin secretion" ; rdfs:subClassOf obo:GO_0090273, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070253 ] ) ] . obo:GO_0090276 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:56:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090276" ; a owl:Class ; rdfs:label "regulation of peptide hormone secretion" ; rdfs:subClassOf obo:GO_0002791, obo:GO_0046883, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030072 ] ) ] . obo:GO_0090277 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:56:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090277" ; a owl:Class ; rdfs:label "positive regulation of peptide hormone secretion" ; rdfs:subClassOf obo:GO_0002793, obo:GO_0046887, obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030072 ] ) ] . obo:GO_0090278 obo:IAO_0000115 "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-02-05T02:56:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090278" ; a owl:Class ; rdfs:label "negative regulation of peptide hormone secretion" ; rdfs:subClassOf obo:GO_0002792, obo:GO_0046888, obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030072 ] ) ] . obo:GO_0090303 obo:IAO_0000115 "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-03-22T02:12:03Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090303" ; a owl:Class ; rdfs:label "positive regulation of wound healing" ; rdfs:subClassOf obo:GO_0061041, obo:GO_1903036, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042060 ] ) ] . obo:GO_0090304 obo:IAO_0000115 "Any cellular metabolic process involving nucleic acids." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-04-07T10:18:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090304" ; a owl:Class ; rdfs:label "nucleic acid metabolic process" ; rdfs:subClassOf obo:GO_0006139, obo:GO_0043170 . obo:GO_0090316 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-04-16T03:45:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090316" ; a owl:Class ; rdfs:label "positive regulation of intracellular protein transport" ; rdfs:subClassOf obo:GO_0032388, obo:GO_0033157, obo:GO_0051222, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006886 ] ) ] . obo:GO_0090317 obo:IAO_0000115 "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-04-16T03:45:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090317" ; a owl:Class ; rdfs:label "negative regulation of intracellular protein transport" ; rdfs:subClassOf obo:GO_0032387, obo:GO_0033157, obo:GO_0051224, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006886 ] ) ] . obo:GO_0090322 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-06T02:29:05Z" ; oboInOwl:hasExactSynonym "regulation of superoxide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090322" ; a owl:Class ; rdfs:label "regulation of superoxide metabolic process" ; rdfs:subClassOf obo:GO_2000377, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006801 ] ) ] . obo:GO_0090325 obo:IAO_0000115 "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-14T10:24:29Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090325" ; a owl:Class ; rdfs:label "regulation of locomotion involved in locomotory behavior" ; rdfs:subClassOf obo:GO_0040012, obo:GO_0050795, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0031987 ] ) ] . obo:GO_0090326 obo:IAO_0000115 "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-14T10:26:58Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090326" ; a owl:Class ; rdfs:label "positive regulation of locomotion involved in locomotory behavior" ; rdfs:subClassOf obo:GO_0040017, obo:GO_0048520, obo:GO_0090325, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050789 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0031987 ] ) ] . obo:GO_0090327 obo:IAO_0000115 "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-14T10:26:58Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090327" ; a owl:Class ; rdfs:label "negative regulation of locomotion involved in locomotory behavior" ; rdfs:subClassOf obo:GO_0040013, obo:GO_0048521, obo:GO_0090325, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031987 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0031987 ] ) ] . obo:GO_0090330 obo:IAO_0000115 "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-14T10:46:08Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090330" ; a owl:Class ; rdfs:label "regulation of platelet aggregation" ; rdfs:subClassOf obo:GO_0010543, obo:GO_0034110, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070527 ] ) ] . obo:GO_0090331 obo:IAO_0000115 "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-05-14T10:46:08Z" ; oboInOwl:hasNarrowSynonym "platelet disaggregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090331" ; a owl:Class ; rdfs:label "negative regulation of platelet aggregation" ; rdfs:subClassOf obo:GO_0010544, obo:GO_0034111, obo:GO_0090330, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070527 ] ) ] . obo:GO_0090357 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-06-29T02:38:48Z" ; oboInOwl:hasExactSynonym "regulation of tryptophan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090357" ; a owl:Class ; rdfs:label "regulation of tryptophan metabolic process" ; rdfs:subClassOf obo:GO_0006521, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006568 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006568 ] ) ] . obo:GO_0090358 obo:IAO_0000115 "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-06-29T02:38:48Z" ; oboInOwl:hasExactSynonym "positive regulation of tryptophan metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090358" ; a owl:Class ; rdfs:label "positive regulation of tryptophan metabolic process" ; rdfs:subClassOf obo:GO_0045764, obo:GO_0090357, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006568 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006568 ] ) ] . obo:GO_0090368 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-07-12T11:14:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090368" ; a owl:Class ; rdfs:label "regulation of ornithine metabolic process" ; rdfs:subClassOf obo:GO_0006521, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006591 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006591 ] ) ] . obo:GO_0090394 obo:IAO_0000115 "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-12-15T01:43:12Z" ; oboInOwl:hasExactSynonym "negative regulation of excitatory post-synaptic membrane potential", "reduction of excitatory postsynaptic membrane potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of EPSP" ; oboInOwl:id "GO:0090394" ; a owl:Class ; rdfs:label "negative regulation of excitatory postsynaptic potential" ; rdfs:subClassOf obo:GO_0048519, obo:GO_0098815, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060079 ] ) ] . obo:GO_0090594 obo:IAO_0000115 "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2014-08-12T12:13:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090594" ; a owl:Class ; rdfs:label "inflammatory response to wounding" ; rdfs:subClassOf obo:GO_0006954, obo:GO_0009611 . obo:GO_0090713 obo:IAO_0000115 "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2016-11-11T12:20:30Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090713" ; a owl:Class ; rdfs:label "immunological memory process" ; rdfs:subClassOf obo:GO_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006955 ] . obo:GO_0090715 obo:IAO_0000115 "Any immunological memory process that can contribute to the formation of immunological memory." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2016-11-11T12:25:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0090715" ; a owl:Class ; rdfs:label "immunological memory formation process" ; rdfs:subClassOf obo:GO_0090713 . obo:GO_0097014 obo:IAO_0000115 "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-03-23T01:52:31Z" ; oboInOwl:hasExactSynonym "cilium plasm" ; oboInOwl:hasNarrowSynonym "microtubule-based flagellar matrix", "microtubule-based flagellum matrix" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "cilial cytoplasm", "ciliary cytoplasm", "cilium cytoplasm", "microtubule-based flagellar cytoplasm", "microtubule-based flagellum cytoplasm" ; oboInOwl:id "GO:0097014" ; a owl:Class ; rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term \"ciliary plasm\" is not linked to \"cytoplasm\"." ; rdfs:label "ciliary plasm" ; rdfs:subClassOf obo:GO_0032838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005929 ] ) ] . obo:GO_0097028 obo:IAO_0000115 "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-04-01T10:08:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097028" ; a owl:Class ; rdfs:comment "Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'." ; rdfs:label "dendritic cell differentiation" ; rdfs:subClassOf obo:GO_1903131 . obo:GO_0097060 obo:IAO_0000115 "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-06-07T11:22:09Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0097060" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "synaptic membrane" ; rdfs:subClassOf obo:GO_0098590, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0098590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0045202 ] ) ] . obo:GO_0097186 obo:IAO_0000115 "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-11-21T09:01:24Z" ; oboInOwl:hasExactSynonym "enamel development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097186" ; a owl:Class ; rdfs:label "amelogenesis" ; rdfs:subClassOf obo:GO_0042475, obo:GO_0048646 . obo:GO_0097194 obo:IAO_0000115 "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-11-23T09:45:24Z" ; oboInOwl:hasExactSynonym "execution phase of apoptotic process" ; oboInOwl:hasNarrowSynonym "apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097194" ; a owl:Class ; rdfs:label "execution phase of apoptosis" ; rdfs:subClassOf obo:GO_0009987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006915 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0032060 ] . obo:GO_0097205 obo:IAO_0000115 "A renal system process in which fluid circulating through the body is filtered through a barrier system." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-01-03T03:10:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097205" ; a owl:Class ; rdfs:label "renal filtration" ; rdfs:subClassOf obo:GO_0003014 . obo:GO_0097254 obo:IAO_0000115 "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22368"^^xsd:anyURI ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-03-05T02:03:58Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097254" ; a owl:Class ; rdfs:label "renal tubular secretion" ; rdfs:subClassOf obo:GO_0003014, obo:GO_0007588 . obo:GO_0097447 obo:IAO_0000115 "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-12-17T12:31:49Z" ; oboInOwl:hasDbXref "NIF_Subcellular:sao172297168" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0097447" ; a owl:Class ; rdfs:label "dendritic tree" ; rdfs:subClassOf obo:GO_0043005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0036477 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030425 ] . obo:GO_0097529 obo:IAO_0000115 "The movement of a myeloid leukocyte within or between different tissues and organs of the body." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-11-11T13:59:43Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097529" ; a owl:Class ; rdfs:label "myeloid leukocyte migration" ; rdfs:subClassOf obo:GO_0050900 . obo:GO_0097530 obo:IAO_0000115 "The movement of a granulocyte within or between different tissues and organs of the body." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-11-11T14:00:44Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097530" ; a owl:Class ; rdfs:label "granulocyte migration" ; rdfs:subClassOf obo:GO_0097529 . obo:GO_0097708 obo:IAO_0000115 "Any vesicle that is part of the intracellular region." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-03-29T17:39:45Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0097708" ; a owl:Class ; rdfs:label "intracellular vesicle" ; rdfs:subClassOf obo:GO_0031982, obo:GO_0043231 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ) ] . obo:GO_0097712 obo:IAO_0000115 "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-08-05T16:16:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097712" ; a owl:Class ; rdfs:label "vesicle targeting, trans-Golgi to periciliary membrane compartment" ; rdfs:subClassOf obo:GO_0048199, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060271 ] . obo:GO_0097722 obo:IAO_0000115 "Any process involved in the controlled movement of a sperm cell." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-09-01T12:00:45Z" ; oboInOwl:hasExactSynonym "sperm movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0097722" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "sperm motility" ; rdfs:subClassOf obo:GO_0022414, obo:GO_0048870 . obo:GO_0097734 obo:IAO_0000115 "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-10-03T14:35:25Z" ; oboInOwl:hasExactSynonym "exosome assembly or secretion", "exosome biogenesis", "exosome production" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "ILV assembly", "intraluminal vesicle assembly" ; oboInOwl:id "GO:0097734" ; a owl:Class ; rdfs:label "extracellular exosome biogenesis" ; rdfs:subClassOf obo:GO_0140112 . obo:GO_0098542 obo:IAO_0000115 "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22173"^^xsd:anyURI ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2013-11-11T12:59:11Z" ; oboInOwl:hasAlternativeId "GO:0009814" ; oboInOwl:hasNarrowSynonym "defence response incompatible interaction", "defence response to pathogen, incompatible interaction", "defense response, incompatible interaction", "resistance response to pathogen" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098542" ; oboInOwl:inSubset go:goslim_generic, go:prokaryote_subset ; a owl:Class ; rdfs:label "defense response to other organism" ; rdfs:subClassOf obo:GO_0006952, obo:GO_0051707 . obo:GO_0098588 obo:IAO_0000115 "The lipid bilayer that forms the outer-most layer of an organelle." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2014-02-26T13:41:31Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098588" ; a owl:Class ; rdfs:comment "Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes." ; rdfs:label "bounding membrane of organelle" ; rdfs:subClassOf obo:GO_0031090 . obo:GO_0098590 obo:IAO_0000115 "A membrane that is a (regional) part of the plasma membrane." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2014-03-06T11:55:32Z" ; oboInOwl:hasExactSynonym "region of plasma membrane" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098590" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass." ; rdfs:label "plasma membrane region" ; rdfs:subClassOf obo:GO_0016020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ) ] . obo:GO_0098609 obo:IAO_0000115 "The attachment of one cell to another cell via adhesion molecules." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2014-04-16T13:40:03Z" ; oboInOwl:hasAlternativeId "GO:0016337" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "single organismal cell-cell adhesion" ; oboInOwl:id "GO:0098609" ; a owl:Class ; rdfs:label "cell-cell adhesion" ; rdfs:subClassOf obo:GO_0007155 . obo:GO_0098642 obo:IAO_0000115 "A collagen trimer that forms networks." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098642" ; a owl:Class ; rdfs:label "network-forming collagen trimer" ; rdfs:subClassOf obo:GO_0005581, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098645 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005581 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098645 ] ) ] . obo:GO_0098643 obo:IAO_0000115 "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098643" ; a owl:Class ; rdfs:label "banded collagen fibril" ; rdfs:subClassOf obo:GO_0098644, obo:GO_0099512 . obo:GO_0098644 obo:IAO_0000115 "A complex of collagen trimers such as a fibril or collagen network." ; oboInOwl:hasExactSynonym "Supramolecular aggregate of collagen", "Supramolecular collagen assembly" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098644" ; a owl:Class ; rdfs:label "complex of collagen trimers" ; rdfs:subClassOf obo:GO_0099080, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0062023 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005581 ] . obo:GO_0098645 obo:IAO_0000115 "A supramolecular complex that consists of collagen triple helices associated to form a network." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098645" ; a owl:Class ; rdfs:label "collagen network" ; rdfs:subClassOf obo:GO_0098644, obo:GO_0099081 . obo:GO_0098651 obo:IAO_0000115 "Any collagen timer that is part of a basement membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098651" ; a owl:Class ; rdfs:label "basement membrane collagen trimer" ; rdfs:subClassOf obo:GO_0005581, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005581 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005604 ] ) ] . obo:GO_0098657 obo:IAO_0000115 "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." ; oboInOwl:hasBroadSynonym "uptake" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098657" ; a owl:Class ; rdfs:label "import into cell" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0098754 obo:IAO_0000115 "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098754" ; oboInOwl:inSubset go:goslim_generic, go:goslim_pombe, go:prokaryote_subset ; a owl:Class ; rdfs:label "detoxification" ; rdfs:subClassOf obo:GO_0008150, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0009636 ] . obo:GO_0098771 obo:IAO_0000115 "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098771" ; oboInOwl:inSubset go:goslim_pombe ; a owl:Class ; rdfs:label "inorganic ion homeostasis" ; rdfs:subClassOf obo:GO_0048878 . obo:GO_0098793 obo:IAO_0000115 "The part of a synapse that is part of the presynaptic cell." ; oboInOwl:hasExactSynonym "presynaptic terminal" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098793" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "presynapse" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0045202 ] . obo:GO_0098794 obo:IAO_0000115 "The part of a synapse that is part of the post-synaptic cell." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098794" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynapse" ; rdfs:subClassOf obo:GO_0110165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0045202 ] . obo:GO_0098796 obo:IAO_0000115 "Any protein complex that is part of a membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098796" ; oboInOwl:inSubset go:goslim_metagenomics ; a owl:Class ; rdfs:label "membrane protein complex" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0016020 ] ) ] . obo:GO_0098797 obo:IAO_0000115 "Any protein complex that is part of the plasma membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098797" ; a owl:Class ; rdfs:label "plasma membrane protein complex" ; rdfs:subClassOf obo:GO_0098796, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005886 ] ) ] . obo:GO_0098798 obo:IAO_0000115 "A protein complex that is part of a mitochondrion." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "mitochondrial protein complex" ; oboInOwl:id "GO:0098798" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "mitochondrial protein-containing complex" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0098800 obo:IAO_0000115 "Any protein complex that is part of the inner mitochondrial membrane." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098800" ; a owl:Class ; rdfs:label "inner mitochondrial membrane protein complex" ; rdfs:subClassOf obo:GO_0098796, obo:GO_0098798, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005743 ] ) ] . obo:GO_0098801 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098801" ; a owl:Class ; rdfs:label "regulation of renal system process" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003014 ] ) ] . obo:GO_0098802 obo:IAO_0000115 "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098802" ; oboInOwl:inSubset go:gocheck_do_not_manually_annotate ; a owl:Class ; rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ; rdfs:label "plasma membrane signaling receptor complex" ; rdfs:subClassOf obo:GO_0043235, obo:GO_0098797 . obo:GO_0098803 obo:IAO_0000115 "Any protein complex that is part of a respiratory chain." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098803" ; a owl:Class ; rdfs:label "respiratory chain complex" ; rdfs:subClassOf obo:GO_0098796, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0070469 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0070469 ] ) ] . obo:GO_0098813 obo:IAO_0000115 "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098813" ; a owl:Class ; rdfs:label "nuclear chromosome segregation" ; rdfs:subClassOf obo:GO_0007059 . obo:GO_0098815 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098815" ; a owl:Class ; rdfs:label "modulation of excitatory postsynaptic potential" ; rdfs:subClassOf obo:GO_0009966, obo:GO_0031644, obo:GO_0042391, obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050789 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060079 ] ) ] . obo:GO_0098858 obo:IAO_0000115 "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098858" ; a owl:Class ; rdfs:label "actin-based cell projection" ; rdfs:subClassOf obo:GO_0120025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005884 ] . obo:GO_0098871 obo:IAO_0000115 "The actin cytoskeleton that is part of a postsynapse." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0098871" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynaptic actin cytoskeleton" ; rdfs:subClassOf obo:GO_0015629, obo:GO_0099571 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0015629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0098900 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098900" ; a owl:Class ; rdfs:comment "The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term." ; rdfs:label "regulation of action potential" ; rdfs:subClassOf obo:GO_0042391, obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050789 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001508 ] ) ] . obo:GO_0098916 obo:IAO_0000115 "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098916" ; a owl:Class ; rdfs:label "anterograde trans-synaptic signaling" ; rdfs:subClassOf obo:GO_0099537 . obo:GO_0098976 obo:IAO_0000115 "Synaptic transmission that results in an excitatory postsynaptic potential." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0098976" ; a owl:Class ; rdfs:label "excitatory chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0007268, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0060079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007268 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0060079 ] ) ] . obo:GO_0099003 obo:IAO_0000115 "Any vesicle-mediated transport that occurs in a synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099003" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "vesicle-mediated transport in synapse" ; rdfs:subClassOf obo:GO_0016192, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0016192 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ) ] . obo:GO_0099080 obo:IAO_0000115 "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099080" ; a owl:Class ; rdfs:label "supramolecular complex" ; rdfs:subClassOf obo:GO_0110165 . obo:GO_0099081 obo:IAO_0000115 "A polymeric supramolecular structure." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099081" ; a owl:Class ; rdfs:label "supramolecular polymer" ; rdfs:subClassOf obo:GO_0099080 . obo:GO_0099111 obo:IAO_0000115 "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099111" ; a owl:Class ; rdfs:label "microtubule-based transport" ; rdfs:subClassOf obo:GO_0006810 . obo:GO_0099123 obo:IAO_0000115 "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." ; oboInOwl:hasExactSynonym "STD DA release", "STD dopamine release", "somatodendritic dopamine release" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099123" ; a owl:Class ; rdfs:label "somato-dendritic dopamine secretion" ; rdfs:subClassOf obo:GO_0014046, obo:GO_0051649, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0036477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0014046 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0036477 ] ) ] . obo:GO_0099124 obo:IAO_0000115 "The regulated release of dopamine from an axon." ; oboInOwl:hasExactSynonym "axonal DA release", "axonal dopamine release" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099124" ; a owl:Class ; rdfs:label "axonal dopamine secretion" ; rdfs:subClassOf obo:GO_0014046, obo:GO_0051649, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0030424 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0014046 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0030424 ] ) ] . obo:GO_0099143 obo:IAO_0000115 "The actin cytoskeleton that is part of a presynapse." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2017-06-09T18:36:19Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099143" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "presynaptic actin cytoskeleton" ; rdfs:subClassOf obo:GO_0015629, obo:GO_0099569 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0015629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0099160 obo:IAO_0000115 "The intermediate filament cytoskeleton that is part of a postsynapse." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2017-08-28T15:26:08Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099160" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynaptic intermediate filament cytoskeleton" ; rdfs:subClassOf obo:GO_0045111, obo:GO_0099571 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0099170 obo:IAO_0000115 "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2017-09-11T17:09:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099170" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynaptic modulation of chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050804 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0099171 obo:IAO_0000115 "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2017-09-11T17:09:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099171" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "presynaptic modulation of chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050804 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0099177 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099177" ; a owl:Class ; rdfs:label "regulation of trans-synaptic signaling" ; rdfs:subClassOf obo:GO_0010646, obo:GO_0023051, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0099537 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0099537 ] ) ] . obo:GO_0099182 obo:IAO_0000115 "The intermediate filament cytoskeleton that is part of a presynapse." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2017-12-01T18:10:21Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099182" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "presynaptic intermediate filament cytoskeleton" ; rdfs:subClassOf obo:GO_0045111, obo:GO_0099569 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0045111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0099500 obo:IAO_0000115 "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099500" ; a owl:Class ; rdfs:label "vesicle fusion to plasma membrane" ; rdfs:subClassOf obo:GO_0006906, obo:GO_0140029 . obo:GO_0099503 obo:IAO_0000115 "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099503" ; oboInOwl:inSubset go:goslim_drosophila ; a owl:Class ; rdfs:label "secretory vesicle" ; rdfs:subClassOf obo:GO_0031410 . obo:GO_0099512 obo:IAO_0000115 "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." ; oboInOwl:hasAlternativeId "GO:0043205" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "fibril" ; oboInOwl:id "GO:0099512" ; a owl:Class ; rdfs:label "supramolecular fiber" ; rdfs:subClassOf obo:GO_0099081 . obo:GO_0099513 obo:IAO_0000115 "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099513" ; a owl:Class ; rdfs:label "polymeric cytoskeletal fiber" ; rdfs:subClassOf obo:GO_0099512, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005856 ] . obo:GO_0099530 obo:IAO_0000115 "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." ; oboInOwl:hasExactSynonym "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:0099530" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential" ; rdfs:subClassOf obo:GO_0004930, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060078 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045211 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0004930 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060078 ] ) ] . obo:GO_0099531 obo:IAO_0000115 "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099531" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_synapse ; a owl:Class ; rdfs:label "presynaptic process involved in chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0050877, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050877 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007268 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0099536 obo:IAO_0000115 "Cell-cell signaling to, from or within a synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099536" ; oboInOwl:inSubset go:goslim_drosophila, go:goslim_synapse ; a owl:Class ; rdfs:label "synaptic signaling" ; rdfs:subClassOf obo:GO_0007267, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007267 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ) ] . obo:GO_0099537 obo:IAO_0000115 "Cell-cell signaling in either direction across the synaptic cleft." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099537" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "trans-synaptic signaling" ; rdfs:subClassOf obo:GO_0099536 . obo:GO_0099547 obo:IAO_0000115 "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099547" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at synapse, modulating synaptic transmission" ; rdfs:subClassOf obo:GO_0050804, obo:GO_0140243 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0099550 obo:IAO_0000115 "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099550" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "trans-synaptic signaling, modulating synaptic transmission" ; rdfs:subClassOf obo:GO_0050804, obo:GO_0099537 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0099537 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0099565 obo:IAO_0000115 "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "postsynaptic process involved in chemical synaptic transmission" ; oboInOwl:id "GO:0099565" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "chemical synaptic transmission, postsynaptic" ; rdfs:subClassOf obo:GO_0050877, obo:GO_1905114, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007268 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007268 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0099568 obo:IAO_0000115 "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099568" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "cytoplasmic region" ; rdfs:subClassOf obo:GO_0005737, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005737 ] ) ] . obo:GO_0099569 obo:IAO_0000115 "The portion of the cytoskeleton contained within the presynapse." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099569" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "presynaptic cytoskeleton" ; rdfs:subClassOf obo:GO_0005856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0099571 obo:IAO_0000115 "The portion of the cytoskeleton contained within the postsynapse." ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099571" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "postsynaptic cytoskeleton" ; rdfs:subClassOf obo:GO_0005856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0099577 obo:IAO_0000115 "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099577" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at presynapse, modulating synaptic transmission" ; rdfs:subClassOf obo:GO_0099171, obo:GO_0099547, obo:GO_0140244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0099578 obo:IAO_0000115 "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099578" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at postsynapse, modulating synaptic transmission" ; rdfs:subClassOf obo:GO_0099170, obo:GO_0099547, obo:GO_0140245 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0099643 obo:IAO_0000115 "Any signal release from a synapse." ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0099643" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:label "signal release from synapse" ; rdfs:subClassOf obo:GO_0023061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0099536 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0023061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ) ] . obo:GO_0099738 obo:IAO_0000115 "The complete extent of cell cortex that underlies some some region of the plasma membrane." ; oboInOwl:hasExactSynonym "perimembrane region" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0099738" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "cell cortex region" ; rdfs:subClassOf obo:GO_0005938, obo:GO_0099568, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005938 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005938 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005938 ] ) ] . obo:GO_0100001 obo:IAO_0000115 "Any action potential process that regulates skeletal muscle contraction." ; oboInOwl:created_by "cjm" ; oboInOwl:creation_date "2015-04-02T04:13:19Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0100001" ; a owl:Class ; rdfs:label "regulation of skeletal muscle contraction by action potential" ; rdfs:subClassOf obo:GO_0001508, obo:GO_0014819 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0001508 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003009 ] ) ] . obo:GO_0106014 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2017-04-28T20:03:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106014" ; a owl:Class ; rdfs:label "regulation of inflammatory response to wounding" ; rdfs:subClassOf obo:GO_0050727, obo:GO_1903034, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0090594 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0090594 ] ) ] . obo:GO_0106015 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2017-04-28T20:09:46Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106015" ; a owl:Class ; rdfs:label "negative regulation of inflammatory response to wounding" ; rdfs:subClassOf obo:GO_0050728, obo:GO_0106014, obo:GO_1903035, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0090594 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0090594 ] ) ] . obo:GO_0106016 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2017-04-28T20:16:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106016" ; a owl:Class ; rdfs:label "positive regulation of inflammatory response to wounding" ; rdfs:subClassOf obo:GO_0050729, obo:GO_0106014, obo:GO_1903036, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0090594 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0090594 ] ) ] . obo:GO_0106064 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2017-10-27T17:33:05Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106064" ; a owl:Class ; rdfs:label "regulation of cobalamin metabolic process" ; rdfs:subClassOf obo:GO_0030656, obo:GO_1901401, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009235 ] ) ] . obo:GO_0106121 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2018-05-01T18:07:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106121" ; a owl:Class ; rdfs:label "positive regulation of cobalamin metabolic process" ; rdfs:subClassOf obo:GO_0046136, obo:GO_0106064, obo:GO_1901403, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009235 ] ) ] . obo:GO_0106122 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2018-05-01T18:12:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0106122" ; a owl:Class ; rdfs:label "negative regulation of cobalamin metabolic process" ; rdfs:subClassOf obo:GO_0046137, obo:GO_0106064, obo:GO_1901402, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009235 ] ) ] . obo:GO_0110110 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2018-07-05T14:10:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0110110" ; a owl:Class ; rdfs:label "positive regulation of animal organ morphogenesis" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0051240, obo:GO_2000027, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009887 ] ) ] . obo:GO_0110111 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2018-07-05T14:25:21Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0110111" ; a owl:Class ; rdfs:label "negative regulation of animal organ morphogenesis" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_2000027, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009887 ] ) ] . obo:GO_0110165 obo:IAO_0000115 "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2019-08-12T18:01:37Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0110165" ; oboInOwl:inSubset go:goslim_pir ; a owl:Class ; rdfs:label "cellular anatomical entity" ; rdfs:subClassOf obo:GO_0005575 . obo:GO_0120025 obo:IAO_0000115 "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13193"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-03-21T17:26:07Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0120025" ; a owl:Class ; rdfs:label "plasma membrane bounded cell projection" ; rdfs:subClassOf obo:GO_0042995, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0098590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0042995 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0098590 ] ) ] . obo:GO_0120031 obo:IAO_0000115 "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-24T23:56:08Z" ; oboInOwl:hasNarrowSynonym "eupodium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120031" ; a owl:Class ; rdfs:label "plasma membrane bounded cell projection assembly" ; rdfs:subClassOf obo:GO_0030031, obo:GO_0120036 . obo:GO_0120032 obo:IAO_0000115 "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-26T04:27:04Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120032" ; a owl:Class ; rdfs:label "regulation of plasma membrane bounded cell projection assembly" ; rdfs:subClassOf obo:GO_0060491, obo:GO_0120035, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0120031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0120031 ] ) ] . obo:GO_0120033 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-26T04:34:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120033" ; a owl:Class ; rdfs:label "negative regulation of plasma membrane bounded cell projection assembly" ; rdfs:subClassOf obo:GO_0031345, obo:GO_0120032, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0120031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0120031 ] ) ] . obo:GO_0120034 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-26T04:34:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120034" ; a owl:Class ; rdfs:label "positive regulation of plasma membrane bounded cell projection assembly" ; rdfs:subClassOf obo:GO_0031346, obo:GO_0044089, obo:GO_0120032, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0120031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0120031 ] ) ] . obo:GO_0120035 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-26T16:02:06Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120035" ; a owl:Class ; rdfs:label "regulation of plasma membrane bounded cell projection organization" ; rdfs:subClassOf obo:GO_0031344, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0120036 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0120036 ] ) ] . obo:GO_0120036 obo:IAO_0000115 "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13298"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-04-26T16:07:02Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120036" ; a owl:Class ; rdfs:label "plasma membrane bounded cell projection organization" ; rdfs:subClassOf obo:GO_0030030 . obo:GO_0120054 obo:IAO_0000115 "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/13607"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-06-13T20:42:24Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120054" ; a owl:Class ; rdfs:label "intestinal motility" ; rdfs:subClassOf obo:GO_0022600 . obo:GO_0120111 obo:IAO_0000115 "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14472"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2017-11-01T18:58:12Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0120111" ; a owl:Class ; rdfs:label "neuron projection cytoplasm" ; rdfs:subClassOf obo:GO_0032838, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0043005 ] ) ] . obo:GO_0120178 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/16000"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2019-05-20T22:34:00Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120178" ; a owl:Class ; rdfs:label "steroid hormone biosynthetic process" ; rdfs:subClassOf obo:GO_0006694 . obo:GO_0120188 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/16040"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2018-07-16T22:28:58Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120188" ; a owl:Class ; rdfs:label "regulation of bile acid secretion" ; rdfs:subClassOf obo:GO_0032890, obo:GO_0051046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032782 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032782 ] ) ] . obo:GO_0120189 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/16040"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2018-07-16T22:36:17Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120189" ; a owl:Class ; rdfs:label "positive regulation of bile acid secretion" ; rdfs:subClassOf obo:GO_0032892, obo:GO_0051047, obo:GO_0120188, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032782 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032782 ] ) ] . obo:GO_0120190 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/16040"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2018-07-16T22:38:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120190" ; a owl:Class ; rdfs:label "negative regulation of bile acid secretion" ; rdfs:subClassOf obo:GO_0032891, obo:GO_0051048, obo:GO_0120188, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032782 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032782 ] ) ] . obo:GO_0120305 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20524"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2021-02-09T19:37:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120305" ; a owl:Class ; rdfs:label "regulation of pigmentation" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0043473 ] ) ] . obo:GO_0120316 obo:IAO_0000115 "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/21361"^^xsd:anyURI ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2021-04-29T01:27:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0120316" ; a owl:Class ; rdfs:label "sperm flagellum assembly" ; rdfs:subClassOf obo:GO_0003006, obo:GO_0022412, obo:GO_0044458, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007286 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030317 ] . obo:GO_0140013 obo:IAO_0000115 "One of the two nuclear divisions that occur as part of the meiotic cell cycle." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19910"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2017-03-23T09:40:00Z" ; oboInOwl:hasExactSynonym "meiosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140013" ; oboInOwl:inSubset go:goslim_generic ; a owl:Class ; rdfs:label "meiotic nuclear division" ; rdfs:subClassOf obo:GO_0000280, obo:GO_1903046 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_0140014 obo:IAO_0000115 "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19910"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2017-03-23T14:44:23Z" ; oboInOwl:hasExactSynonym "mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140014" ; oboInOwl:inSubset go:goslim_chembl, go:goslim_generic ; a owl:Class ; rdfs:label "mitotic nuclear division" ; rdfs:subClassOf obo:GO_0000280, obo:GO_1903047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000280 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_0140029 obo:IAO_0000115 "The cellular processes that contribute to exocytosis." ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2017-05-15T13:20:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140029" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "exocytic process" ; rdfs:subClassOf obo:GO_0009987, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0006887 ] ) ] . obo:GO_0140053 obo:IAO_0000115 "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2017-06-26T10:57:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140053" ; oboInOwl:inSubset go:goslim_generic, go:goslim_pombe ; a owl:Class ; rdfs:label "mitochondrial gene expression" ; rdfs:subClassOf obo:GO_0010467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0010467 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_0140112 obo:IAO_0000115 "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14256"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2017-10-23T11:53:42Z" ; oboInOwl:hasExactSynonym "extracellular vesicle assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140112" ; a owl:Class ; rdfs:label "extracellular vesicle biogenesis" ; rdfs:subClassOf obo:GO_0044085 . obo:GO_0140236 obo:IAO_0000115 "Translation that occurs at the presynapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/216"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-13T13:00:33Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140236" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "translation at presynapse" ; rdfs:subClassOf obo:GO_0140241, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0140237 obo:IAO_0000115 "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/216"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-13T13:07:23Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140237" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "translation at presynapse, modulating chemical synaptic transmission" ; rdfs:subClassOf obo:GO_0140236, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007268 ] ) ] . obo:GO_0140238 obo:IAO_0000115 "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/230"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T07:33:55Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140238" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "presynaptic endocytosis" ; rdfs:subClassOf obo:GO_0006897, obo:GO_0051649, obo:GO_0099003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ) ] . obo:GO_0140239 obo:IAO_0000115 "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/230"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T07:38:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140239" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "postsynaptic endocytosis" ; rdfs:subClassOf obo:GO_0006897, obo:GO_0051649, obo:GO_0099003, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0140241 obo:IAO_0000115 "Translation that occurs at the synapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/210"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T09:23:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140241" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "translation at synapse" ; rdfs:subClassOf obo:GO_0006412, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ) ] . obo:GO_0140242 obo:IAO_0000115 "Translation that occurs at the postsynapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/210"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T09:26:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140242" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "translation at postsynapse" ; rdfs:subClassOf obo:GO_0140241, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ) ] . obo:GO_0140243 obo:IAO_0000115 "Any process that regulates translation occurring at the synapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/210"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T09:38:26Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140243" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at synapse" ; rdfs:subClassOf obo:GO_0006417, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0045202 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0140244 obo:IAO_0000115 "Any process that regulates translation occurring at the presynapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/210"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T09:38:33Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140244" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at presynapse" ; rdfs:subClassOf obo:GO_0140243, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098793 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0140245 obo:IAO_0000115 "Any process that regulates translation occurring at the postsynapse." ; obo:IAO_0000233 "https://github.com/geneontology/synapse/issues/210"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2018-07-15T09:38:54Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140245" ; oboInOwl:inSubset go:goslim_synapse ; a owl:Class ; rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ; rdfs:label "regulation of translation at postsynapse" ; rdfs:subClassOf obo:GO_0140243, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0098794 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006412 ] ) ] . obo:GO_0140352 obo:IAO_0000115 "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2019-05-22T11:20:45Z" ; oboInOwl:hasBroadSynonym "efflux" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140352" ; a owl:Class ; rdfs:label "export from cell" ; rdfs:subClassOf obo:GO_0006810, obo:GO_0009987 . obo:GO_0140353 obo:IAO_0000115 "The directed movement of a lipid from a cell, into the extracellular region." ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2019-05-22T11:33:07Z" ; oboInOwl:hasBroadSynonym "lipid efflux" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140353" ; a owl:Class ; rdfs:label "lipid export from cell" ; rdfs:subClassOf obo:GO_0006869, obo:GO_0140352 . obo:GO_0140513 obo:IAO_0000115 "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2020-09-09T05:12:38Z" ; oboInOwl:hasExactSynonym "nuclear complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:0140513" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "nuclear protein-containing complex" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0032991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005634 ] ) ] . obo:GO_0140546 obo:IAO_0000115 "Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/20261"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2020-11-11T17:19:06Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140546" ; a owl:Class ; rdfs:label "defense response to symbiont" ; rdfs:subClassOf obo:GO_0098542 . obo:GO_0140962 obo:IAO_0000115 "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/24554"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2022-12-12T09:11:06Z" ; oboInOwl:hasExactSynonym "multicellular organism level chemical homeostasis", "organismal level chemical homeostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0140962" ; a owl:Class ; rdfs:label "multicellular organismal-level chemical homeostasis" ; rdfs:subClassOf obo:GO_0048871, obo:GO_0048878 . obo:GO_0141060 obo:IAO_0000115 "The disruption of the an anatomical structure of another organism, leading to damage or temporary subversion of that structure." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/25514"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2023-06-07T14:40:30Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0141060" ; a owl:Class ; rdfs:label "disruption of anatomical structure in another organism" ; rdfs:subClassOf obo:GO_0044419 . obo:GO_0141061 obo:IAO_0000115 "The disruption of the a cell of another organism, leading to damage or temporary subversion of that cell." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/25514"^^xsd:anyURI ; oboInOwl:created_by "pg" ; oboInOwl:creation_date "2023-06-07T14:41:21Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:0141061" ; a owl:Class ; rdfs:label "disruption of cell in another organism" ; rdfs:subClassOf obo:GO_0141060 . obo:GO_1900015 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2012-01-11T09:34:27Z" ; oboInOwl:hasNarrowSynonym "regulation of cytokine production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900015" ; a owl:Class ; rdfs:label "regulation of cytokine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001817, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002534 ] ) ] . obo:GO_1900016 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2012-01-11T09:34:31Z" ; oboInOwl:hasBroadSynonym "down regulation of cytokine production involved in acute inflammatory response" ; oboInOwl:hasNarrowSynonym "negative regulation of cytokine production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of cytokine production involved in inflammatory response" ; oboInOwl:id "GO:1900016" ; a owl:Class ; rdfs:label "negative regulation of cytokine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001818, obo:GO_1900015, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002534 ] ) ] . obo:GO_1900017 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2012-01-11T09:34:35Z" ; oboInOwl:hasBroadSynonym "up regulation of cytokine production involved in acute inflammatory response" ; oboInOwl:hasNarrowSynonym "positive regulation of cytokine production involved in acute inflammatory response" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "up regulation of cytokine production involved in inflammatory response" ; oboInOwl:id "GO:1900017" ; a owl:Class ; rdfs:label "positive regulation of cytokine production involved in inflammatory response" ; rdfs:subClassOf obo:GO_0001819, obo:GO_1900015, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002534 ] ) ] . obo:GO_1900046 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of hemostasis." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-01-19T03:23:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900046" ; a owl:Class ; rdfs:label "regulation of hemostasis" ; rdfs:subClassOf obo:GO_0050789, obo:GO_0050878, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007599 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007599 ] ) ] . obo:GO_1900047 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-01-19T03:23:42Z" ; oboInOwl:hasExactSynonym "down regulation of hemostasis", "down-regulation of hemostasis", "downregulation of hemostasis" ; oboInOwl:hasNarrowSynonym "inhibition of hemostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900047" ; a owl:Class ; rdfs:label "negative regulation of hemostasis" ; rdfs:subClassOf obo:GO_0048519, obo:GO_1900046, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007599 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007599 ] ) ] . obo:GO_1900048 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of hemostasis." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2012-01-19T03:23:45Z" ; oboInOwl:hasExactSynonym "up regulation of hemostasis", "up-regulation of hemostasis", "upregulation of hemostasis" ; oboInOwl:hasNarrowSynonym "activation of hemostasis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900048" ; a owl:Class ; rdfs:label "positive regulation of hemostasis" ; rdfs:subClassOf obo:GO_0048518, obo:GO_1900046, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007599 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007599 ] ) ] . obo:GO_1900073 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2012-01-26T10:14:10Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900073" ; a owl:Class ; rdfs:label "regulation of neuromuscular synaptic transmission" ; rdfs:subClassOf obo:GO_0050804, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007274 ] ) ] . obo:GO_1900074 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2012-01-26T10:14:18Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of neuromuscular synaptic transmission", "down-regulation of neuromuscular synaptic transmission", "downregulation of neuromuscular synaptic transmission", "inhibition of neuromuscular synaptic transmission" ; oboInOwl:id "GO:1900074" ; a owl:Class ; rdfs:label "negative regulation of neuromuscular synaptic transmission" ; rdfs:subClassOf obo:GO_0050805, obo:GO_1900073, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007274 ] ) ] . obo:GO_1900075 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2012-01-26T10:14:22Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of neuromuscular synaptic transmission", "up regulation of neuromuscular synaptic transmission", "up-regulation of neuromuscular synaptic transmission", "upregulation of neuromuscular synaptic transmission" ; oboInOwl:id "GO:1900075" ; a owl:Class ; rdfs:label "positive regulation of neuromuscular synaptic transmission" ; rdfs:subClassOf obo:GO_0050806, obo:GO_1900073, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007274 ] ) ] . obo:GO_1900115 obo:IAO_0000115 "Any regulation of signal transduction that takes place in the extracellular region." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-02-22T10:21:48Z" ; oboInOwl:hasExactSynonym "regulation of signaling pathway in extracellular region", "regulation of signalling pathway in extracellular region" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900115" ; a owl:Class ; rdfs:label "extracellular regulation of signal transduction" ; rdfs:subClassOf obo:GO_0009966, [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009966 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_1900116 obo:IAO_0000115 "Any negative regulation of signal transduction that takes place in extracellular region." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-02-22T10:27:56Z" ; oboInOwl:hasExactSynonym "down regulation of signal transduction in extracellular region", "down-regulation of signal transduction in extracellular region", "downregulation of signal transduction in extracellular region", "negative regulation of signaling pathway in extracellular region", "negative regulation of signalling pathway in extracellular region" ; oboInOwl:hasNarrowSynonym "extracellular inhibition of signaling pathway", "inhibition of signal transduction in extracellular region" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900116" ; a owl:Class ; rdfs:label "extracellular negative regulation of signal transduction" ; rdfs:subClassOf obo:GO_0009968, obo:GO_1900115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009968 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_1900117 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-02-22T11:26:20Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900117" ; a owl:Class ; rdfs:label "regulation of execution phase of apoptosis" ; rdfs:subClassOf obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0097194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0097194 ] ) ] . obo:GO_1900118 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-02-22T11:26:24Z" ; oboInOwl:hasExactSynonym "down regulation of execution phase of apoptosis", "down-regulation of execution phase of apoptosis", "downregulation of execution phase of apoptosis" ; oboInOwl:hasNarrowSynonym "inhibition of execution phase of apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900118" ; a owl:Class ; rdfs:label "negative regulation of execution phase of apoptosis" ; rdfs:subClassOf obo:GO_0043066, obo:GO_1900117, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0097194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0097194 ] ) ] . obo:GO_1900119 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-02-22T11:26:27Z" ; oboInOwl:hasExactSynonym "up regulation of execution phase of apoptosis", "up-regulation of execution phase of apoptosis", "upregulation of execution phase of apoptosis" ; oboInOwl:hasNarrowSynonym "activation of execution phase of apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900119" ; a owl:Class ; rdfs:label "positive regulation of execution phase of apoptosis" ; rdfs:subClassOf obo:GO_0043065, obo:GO_1900117, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0097194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0097194 ] ) ] . obo:GO_1900157 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-03-07T08:55:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900157" ; a owl:Class ; rdfs:label "regulation of bone mineralization involved in bone maturation" ; rdfs:subClassOf obo:GO_0030500, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035630 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035630 ] ) ] . obo:GO_1900158 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-03-07T08:55:12Z" ; oboInOwl:hasExactSynonym "down regulation of bone mineralization involved in bone maturation", "down-regulation of bone mineralization involved in bone maturation", "downregulation of bone mineralization involved in bone maturation" ; oboInOwl:hasNarrowSynonym "inhibition of bone mineralization involved in bone maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900158" ; a owl:Class ; rdfs:label "negative regulation of bone mineralization involved in bone maturation" ; rdfs:subClassOf obo:GO_0030502, obo:GO_1900157, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035630 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035630 ] ) ] . obo:GO_1900159 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-03-07T08:55:16Z" ; oboInOwl:hasExactSynonym "up regulation of bone mineralization involved in bone maturation", "up-regulation of bone mineralization involved in bone maturation", "upregulation of bone mineralization involved in bone maturation" ; oboInOwl:hasNarrowSynonym "activation of bone mineralization involved in bone maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1900159" ; a owl:Class ; rdfs:label "positive regulation of bone mineralization involved in bone maturation" ; rdfs:subClassOf obo:GO_0030501, obo:GO_1900157, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035630 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035630 ] ) ] . obo:GO_1900424 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of defense response to bacterium." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2012-04-24T10:12:43Z" ; oboInOwl:hasAlternativeId "GO:1902477" ; oboInOwl:hasExactSynonym "regulation of defence response to bacteria", "regulation of defence response to bacterium", "regulation of defense response to bacteria" ; oboInOwl:hasNarrowSynonym "regulation of defence response to bacterium, incompatible interaction", "regulation of defence response to pathogenic bacteria, incompatible interaction", "regulation of defence response to pathogenic bacterium, incompatible interaction", "regulation of defense response to bacterium, incompatible interaction", "regulation of resistance response to pathogenic bacteria", "regulation of resistance response to pathogenic bacterium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of antibacterial peptide activity" ; oboInOwl:id "GO:1900424" ; a owl:Class ; rdfs:label "regulation of defense response to bacterium" ; rdfs:subClassOf obo:GO_0002831, obo:GO_0031347, obo:GO_0032101, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042742 ] ) ] . obo:GO_1900425 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2012-04-24T10:12:54Z" ; oboInOwl:hasAlternativeId "GO:1902478" ; oboInOwl:hasExactSynonym "down regulation of defence response to bacteria", "down regulation of defence response to bacterium", "down regulation of defense response to bacteria", "down regulation of defense response to bacterium", "down-regulation of defence response to bacteria", "down-regulation of defence response to bacterium", "down-regulation of defense response to bacteria", "down-regulation of defense response to bacterium", "downregulation of defence response to bacteria", "downregulation of defence response to bacterium", "downregulation of defense response to bacteria", "downregulation of defense response to bacterium", "inhibition of defence response to bacteria", "inhibition of defence response to bacterium", "inhibition of defense response to bacteria", "negative regulation of defence response to bacteria", "negative regulation of defence response to bacterium", "negative regulation of defense response to bacteria" ; oboInOwl:hasNarrowSynonym "inhibition of defence response to pathogenic bacteria, incompatible interaction", "inhibition of defence response to pathogenic bacterium, incompatible interaction", "inhibition of defense response to bacterium", "inhibition of defense response to bacterium, incompatible interaction", "inhibition of resistance response to pathogenic bacteria", "inhibition of resistance response to pathogenic bacterium", "inhibition of response to pathogenic bacteria (incompatible interaction)", "inhibition of response to pathogenic bacterium (incompatible interaction)", "negative regulation of defense response to bacterium, incompatible interaction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of antibacterial peptide activity", "down-regulation of antibacterial peptide activity", "downregulation of antibacterial peptide activity", "inhibition of antibacterial peptide activity", "negative regulation of antibacterial peptide activity" ; oboInOwl:id "GO:1900425" ; a owl:Class ; rdfs:label "negative regulation of defense response to bacterium" ; rdfs:subClassOf obo:GO_0002832, obo:GO_0031348, obo:GO_0032102, obo:GO_1900424, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042742 ] ) ] . obo:GO_1900426 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." ; oboInOwl:created_by "dhl" ; oboInOwl:creation_date "2012-04-24T10:13:13Z" ; oboInOwl:hasAlternativeId "GO:1902479" ; oboInOwl:hasExactSynonym "activation of defence response to bacteria", "activation of defence response to bacterium", "activation of defense response to bacteria", "positive regulation of defence response to bacteria", "positive regulation of defence response to bacterium", "positive regulation of defense response to bacteria", "up regulation of defence response to bacteria", "up regulation of defence response to bacterium", "up regulation of defense response to bacteria", "up regulation of defense response to bacterium", "up-regulation of defence response to bacteria", "up-regulation of defence response to bacterium", "up-regulation of defense response to bacteria", "up-regulation of defense response to bacterium", "upregulation of defence response to bacteria", "upregulation of defence response to bacterium", "upregulation of defense response to bacteria", "upregulation of defense response to bacterium" ; oboInOwl:hasNarrowSynonym "activation of defense response to bacterium", "activation of resistance response to pathogenic bacteria", "activation of resistance response to pathogenic bacterium", "positive regulation of defense response to bacterium, incompatible interaction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of antibacterial peptide activity", "positive regulation of antibacterial peptide activity", "up regulation of antibacterial peptide activity", "up-regulation of antibacterial peptide activity", "upregulation of antibacterial peptide activity" ; oboInOwl:id "GO:1900426" ; a owl:Class ; rdfs:label "positive regulation of defense response to bacterium" ; rdfs:subClassOf obo:GO_0002833, obo:GO_0031349, obo:GO_0032103, obo:GO_1900424, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042742 ] ) ] . obo:GO_1901052 obo:IAO_0000115 "The chemical reactions and pathways involving sarcosine." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2012-06-28T04:52:04Z" ; oboInOwl:hasExactSynonym "sarcosine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901052" ; a owl:Class ; rdfs:label "sarcosine metabolic process" ; rdfs:subClassOf obo:GO_0006575, obo:GO_1901605 . obo:GO_1901135 obo:IAO_0000115 "The chemical reactions and pathways involving carbohydrate derivative." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-07-12T04:05:09Z" ; oboInOwl:hasExactSynonym "carbohydrate derivative metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901135" ; oboInOwl:inSubset go:goslim_agr, go:goslim_generic, go:goslim_mouse, go:prokaryote_subset ; a owl:Class ; rdfs:label "carbohydrate derivative metabolic process" ; rdfs:subClassOf obo:GO_0071704 . obo:GO_1901137 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-07-12T04:05:39Z" ; oboInOwl:hasExactSynonym "carbohydrate derivative anabolism", "carbohydrate derivative biosynthesis", "carbohydrate derivative formation", "carbohydrate derivative synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901137" ; a owl:Class ; rdfs:label "carbohydrate derivative biosynthetic process" ; rdfs:subClassOf obo:GO_1901135, obo:GO_1901576 . obo:GO_1901148 obo:IAO_0000115 "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-07-16T03:29:30Z" ; oboInOwl:hasExactSynonym "expression of extracellular matrix proteins" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "extracellular matrix protein production" ; oboInOwl:id "GO:1901148" ; a owl:Class ; rdfs:label "gene expression involved in extracellular matrix organization" ; rdfs:subClassOf obo:GO_0010467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030198 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0010467 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030198 ] ) ] . obo:GO_1901317 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of flagellated sperm motility." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2012-08-22T20:50:14Z" ; oboInOwl:hasBroadSynonym "regulation of sperm motility", "regulation of sperm movement" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901317" ; a owl:Class ; rdfs:label "regulation of flagellated sperm motility" ; rdfs:subClassOf obo:GO_0060295, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030317 ] ) ] . obo:GO_1901318 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2012-08-22T20:50:35Z" ; oboInOwl:hasBroadSynonym "down regulation of sperm motility", "down regulation of sperm movement", "down-regulation of sperm motility", "down-regulation of sperm movement", "downregulation of sperm motility", "downregulation of sperm movement", "inhibition of sperm movement", "negative regulation of sperm motility", "negative regulation of sperm movement" ; oboInOwl:hasNarrowSynonym "inhibition of sperm motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901318" ; a owl:Class ; rdfs:label "negative regulation of flagellated sperm motility" ; rdfs:subClassOf obo:GO_0003354, obo:GO_1901317, obo:GO_1902020, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030317 ] ) ] . obo:GO_1901334 obo:IAO_0000115 "The chemical reactions and pathways involving lactone." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-03T10:26:00Z" ; oboInOwl:hasExactSynonym "lactone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901334" ; a owl:Class ; rdfs:label "lactone metabolic process" ; rdfs:subClassOf obo:GO_0046483, obo:GO_1901360 . obo:GO_1901342 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of vasculature development." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-06T09:16:15Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of vascular system development" ; oboInOwl:id "GO:1901342" ; a owl:Class ; rdfs:label "regulation of vasculature development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001944 ] ) ] . obo:GO_1901343 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-06T09:17:24Z" ; oboInOwl:hasExactSynonym "down regulation of vasculature development", "down-regulation of vasculature development", "downregulation of vasculature development" ; oboInOwl:hasNarrowSynonym "inhibition of vasculature development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of vascular system development", "down-regulation of vascular system development", "downregulation of vascular system development", "inhibition of vascular system development", "negative regulation of vascular system development" ; oboInOwl:id "GO:1901343" ; a owl:Class ; rdfs:label "negative regulation of vasculature development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_1901342, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001944 ] ) ] . obo:GO_1901360 obo:IAO_0000115 "The chemical reactions and pathways involving organic cyclic compound." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-14T09:03:51Z" ; oboInOwl:hasExactSynonym "organic cyclic compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901360" ; a owl:Class ; rdfs:label "organic cyclic compound metabolic process" ; rdfs:subClassOf obo:GO_0071704 . obo:GO_1901362 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of organic cyclic compound." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-14T09:05:22Z" ; oboInOwl:hasExactSynonym "organic cyclic compound anabolism", "organic cyclic compound biosynthesis", "organic cyclic compound formation", "organic cyclic compound synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901362" ; a owl:Class ; rdfs:label "organic cyclic compound biosynthetic process" ; rdfs:subClassOf obo:GO_1901360, obo:GO_1901576 . obo:GO_1901374 obo:IAO_0000115 "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2012-09-28T10:42:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901374" ; a owl:Class ; rdfs:label "acetate ester transport" ; rdfs:subClassOf obo:GO_0071702 . obo:GO_1901401 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-01T14:34:03Z" ; oboInOwl:hasExactSynonym "regulation of tetrapyrrole metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901401" ; a owl:Class ; rdfs:label "regulation of tetrapyrrole metabolic process" ; rdfs:subClassOf obo:GO_0031323, obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033013 ] ) ] . obo:GO_1901402 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-01T14:35:11Z" ; oboInOwl:hasExactSynonym "down regulation of tetrapyrrole metabolic process", "down regulation of tetrapyrrole metabolism", "down-regulation of tetrapyrrole metabolic process", "down-regulation of tetrapyrrole metabolism", "downregulation of tetrapyrrole metabolic process", "downregulation of tetrapyrrole metabolism", "inhibition of tetrapyrrole metabolism", "negative regulation of tetrapyrrole metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of tetrapyrrole metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901402" ; a owl:Class ; rdfs:label "negative regulation of tetrapyrrole metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0051172, obo:GO_1901401, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033013 ] ) ] . obo:GO_1901403 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-01T14:35:29Z" ; oboInOwl:hasExactSynonym "activation of tetrapyrrole metabolism", "positive regulation of tetrapyrrole metabolism", "up regulation of tetrapyrrole metabolic process", "up regulation of tetrapyrrole metabolism", "up-regulation of tetrapyrrole metabolic process", "up-regulation of tetrapyrrole metabolism", "upregulation of tetrapyrrole metabolic process", "upregulation of tetrapyrrole metabolism" ; oboInOwl:hasNarrowSynonym "activation of tetrapyrrole metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901403" ; a owl:Class ; rdfs:label "positive regulation of tetrapyrrole metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0051173, obo:GO_1901401, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033013 ] ) ] . obo:GO_1901463 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-02T14:34:14Z" ; oboInOwl:hasExactSynonym "regulation of tetrapyrrole anabolism", "regulation of tetrapyrrole biosynthesis", "regulation of tetrapyrrole formation", "regulation of tetrapyrrole synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901463" ; a owl:Class ; rdfs:label "regulation of tetrapyrrole biosynthetic process" ; rdfs:subClassOf obo:GO_0031326, obo:GO_1901401, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033014 ] ) ] . obo:GO_1901464 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-02T14:35:26Z" ; oboInOwl:hasExactSynonym "down regulation of tetrapyrrole anabolism", "down regulation of tetrapyrrole biosynthesis", "down regulation of tetrapyrrole biosynthetic process", "down regulation of tetrapyrrole formation", "down regulation of tetrapyrrole synthesis", "down-regulation of tetrapyrrole anabolism", "down-regulation of tetrapyrrole biosynthesis", "down-regulation of tetrapyrrole biosynthetic process", "down-regulation of tetrapyrrole formation", "down-regulation of tetrapyrrole synthesis", "downregulation of tetrapyrrole anabolism", "downregulation of tetrapyrrole biosynthesis", "downregulation of tetrapyrrole biosynthetic process", "downregulation of tetrapyrrole formation", "downregulation of tetrapyrrole synthesis", "inhibition of tetrapyrrole anabolism", "inhibition of tetrapyrrole biosynthesis", "inhibition of tetrapyrrole formation", "inhibition of tetrapyrrole synthesis", "negative regulation of tetrapyrrole anabolism", "negative regulation of tetrapyrrole biosynthesis", "negative regulation of tetrapyrrole formation", "negative regulation of tetrapyrrole synthesis" ; oboInOwl:hasNarrowSynonym "inhibition of tetrapyrrole biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901464" ; a owl:Class ; rdfs:label "negative regulation of tetrapyrrole biosynthetic process" ; rdfs:subClassOf obo:GO_0031327, obo:GO_1901402, obo:GO_1901463, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033014 ] ) ] . obo:GO_1901465 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2012-10-02T14:35:43Z" ; oboInOwl:hasExactSynonym "activation of tetrapyrrole anabolism", "activation of tetrapyrrole biosynthesis", "activation of tetrapyrrole formation", "activation of tetrapyrrole synthesis", "positive regulation of tetrapyrrole anabolism", "positive regulation of tetrapyrrole biosynthesis", "positive regulation of tetrapyrrole formation", "positive regulation of tetrapyrrole synthesis", "up regulation of tetrapyrrole anabolism", "up regulation of tetrapyrrole biosynthesis", "up regulation of tetrapyrrole biosynthetic process", "up regulation of tetrapyrrole formation", "up regulation of tetrapyrrole synthesis", "up-regulation of tetrapyrrole anabolism", "up-regulation of tetrapyrrole biosynthesis", "up-regulation of tetrapyrrole biosynthetic process", "up-regulation of tetrapyrrole formation", "up-regulation of tetrapyrrole synthesis", "upregulation of tetrapyrrole anabolism", "upregulation of tetrapyrrole biosynthesis", "upregulation of tetrapyrrole biosynthetic process", "upregulation of tetrapyrrole formation", "upregulation of tetrapyrrole synthesis" ; oboInOwl:hasNarrowSynonym "activation of tetrapyrrole biosynthetic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901465" ; a owl:Class ; rdfs:label "positive regulation of tetrapyrrole biosynthetic process" ; rdfs:subClassOf obo:GO_0031328, obo:GO_1901403, obo:GO_1901463, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033014 ] ) ] . obo:GO_1901494 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cysteine metabolic process." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2012-10-16T14:28:42Z" ; oboInOwl:hasExactSynonym "regulation of cysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901494" ; a owl:Class ; rdfs:label "regulation of cysteine metabolic process" ; rdfs:subClassOf obo:GO_0006521, obo:GO_0031335, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006534 ] ) ] . obo:GO_1901495 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2012-10-16T14:28:47Z" ; oboInOwl:hasExactSynonym "down regulation of cysteine metabolic process", "down regulation of cysteine metabolism", "down-regulation of cysteine metabolic process", "down-regulation of cysteine metabolism", "downregulation of cysteine metabolic process", "downregulation of cysteine metabolism", "negative regulation of cysteine metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of cysteine metabolic process", "inhibition of cysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901495" ; a owl:Class ; rdfs:label "negative regulation of cysteine metabolic process" ; rdfs:subClassOf obo:GO_0031336, obo:GO_0045763, obo:GO_1901494, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006534 ] ) ] . obo:GO_1901496 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2012-10-16T14:28:51Z" ; oboInOwl:hasExactSynonym "positive regulation of cysteine metabolism", "up regulation of cysteine metabolic process", "up regulation of cysteine metabolism", "up-regulation of cysteine metabolic process", "up-regulation of cysteine metabolism", "upregulation of cysteine metabolic process", "upregulation of cysteine metabolism" ; oboInOwl:hasNarrowSynonym "activation of cysteine metabolic process", "activation of cysteine metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901496" ; a owl:Class ; rdfs:label "positive regulation of cysteine metabolic process" ; rdfs:subClassOf obo:GO_0031337, obo:GO_0045764, obo:GO_1901494, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006534 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006534 ] ) ] . obo:GO_1901532 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-10-24T11:23:01Z" ; oboInOwl:hasExactSynonym "regulation of haematopoietic progenitor cell differentiation", "regulation of haemopoietic progenitor cell differentiation", "regulation of hemopoietic progenitor cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901532" ; a owl:Class ; rdfs:label "regulation of hematopoietic progenitor cell differentiation" ; rdfs:subClassOf obo:GO_0045595, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002244 ] ) ] . obo:GO_1901533 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-10-24T11:23:06Z" ; oboInOwl:hasExactSynonym "down regulation of haematopoietic progenitor cell differentiation", "down regulation of haemopoietic progenitor cell differentiation", "down regulation of hemopoietic progenitor cell differentiation", "down-regulation of haematopoietic progenitor cell differentiation", "down-regulation of haemopoietic progenitor cell differentiation", "down-regulation of hemopoietic progenitor cell differentiation", "downregulation of haematopoietic progenitor cell differentiation", "downregulation of haemopoietic progenitor cell differentiation", "downregulation of hemopoietic progenitor cell differentiation", "inhibition of haematopoietic progenitor cell differentiation", "inhibition of haemopoietic progenitor cell differentiation", "negative regulation of haematopoietic progenitor cell differentiation", "negative regulation of haemopoietic progenitor cell differentiation", "negative regulation of hemopoietic progenitor cell differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of hemopoietic progenitor cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of hematopoietic progenitor cell differentiation", "down-regulation of hematopoietic progenitor cell differentiation", "downregulation of hematopoietic progenitor cell differentiation", "inhibition of hematopoietic progenitor cell differentiation" ; oboInOwl:id "GO:1901533" ; a owl:Class ; rdfs:label "negative regulation of hematopoietic progenitor cell differentiation" ; rdfs:subClassOf obo:GO_0045596, obo:GO_1901532, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002244 ] ) ] . obo:GO_1901534 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2012-10-24T11:23:14Z" ; oboInOwl:hasExactSynonym "activation of haematopoietic progenitor cell differentiation", "activation of haemopoietic progenitor cell differentiation", "positive regulation of haematopoietic progenitor cell differentiation", "positive regulation of haemopoietic progenitor cell differentiation", "positive regulation of hemopoietic progenitor cell differentiation", "up regulation of haematopoietic progenitor cell differentiation", "up regulation of haemopoietic progenitor cell differentiation", "up regulation of hemopoietic progenitor cell differentiation", "up-regulation of haematopoietic progenitor cell differentiation", "up-regulation of haemopoietic progenitor cell differentiation", "up-regulation of hemopoietic progenitor cell differentiation", "upregulation of haematopoietic progenitor cell differentiation", "upregulation of haemopoietic progenitor cell differentiation", "upregulation of hemopoietic progenitor cell differentiation" ; oboInOwl:hasNarrowSynonym "activation of hemopoietic progenitor cell differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of hematopoietic progenitor cell differentiation", "up regulation of hematopoietic progenitor cell differentiation", "up-regulation of hematopoietic progenitor cell differentiation", "upregulation of hematopoietic progenitor cell differentiation" ; oboInOwl:id "GO:1901534" ; a owl:Class ; rdfs:label "positive regulation of hematopoietic progenitor cell differentiation" ; rdfs:subClassOf obo:GO_0045597, obo:GO_1901532, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002244 ] ) ] . obo:GO_1901564 obo:IAO_0000115 "The chemical reactions and pathways involving organonitrogen compound." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-04T15:17:52Z" ; oboInOwl:hasExactSynonym "organonitrogen compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901564" ; a owl:Class ; rdfs:label "organonitrogen compound metabolic process" ; rdfs:subClassOf obo:GO_0006807, obo:GO_0071704 . obo:GO_1901566 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of organonitrogen compound." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-04T15:18:00Z" ; oboInOwl:hasExactSynonym "organonitrogen compound anabolism", "organonitrogen compound biosynthesis", "organonitrogen compound formation", "organonitrogen compound synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901566" ; a owl:Class ; rdfs:label "organonitrogen compound biosynthetic process" ; rdfs:subClassOf obo:GO_1901564, obo:GO_1901576 . obo:GO_1901568 obo:IAO_0000115 "The chemical reactions and pathways involving fatty acid derivative." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-04T17:13:36Z" ; oboInOwl:hasExactSynonym "fatty acid derivative metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901568" ; a owl:Class ; rdfs:label "fatty acid derivative metabolic process" ; rdfs:subClassOf obo:GO_0006629 . obo:GO_1901570 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of fatty acid derivative." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-04T17:13:44Z" ; oboInOwl:hasExactSynonym "fatty acid derivative anabolism", "fatty acid derivative biosynthesis", "fatty acid derivative formation", "fatty acid derivative synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901570" ; a owl:Class ; rdfs:label "fatty acid derivative biosynthetic process" ; rdfs:subClassOf obo:GO_0008610, obo:GO_1901568 . obo:GO_1901575 obo:IAO_0000115 "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-05T11:04:36Z" ; oboInOwl:hasExactSynonym "organic molecular entity breakdown", "organic molecular entity catabolic process", "organic molecular entity catabolism", "organic molecular entity degradation", "organic substance breakdown", "organic substance catabolism", "organic substance degradation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901575" ; a owl:Class ; rdfs:label "organic substance catabolic process" ; rdfs:subClassOf obo:GO_0009056, obo:GO_0071704 . obo:GO_1901576 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-05T11:04:40Z" ; oboInOwl:hasExactSynonym "organic molecular entity anabolism", "organic molecular entity biosynthesis", "organic molecular entity biosynthetic process", "organic molecular entity formation", "organic molecular entity synthesis", "organic substance anabolism", "organic substance biosynthesis", "organic substance formation", "organic substance synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901576" ; a owl:Class ; rdfs:label "organic substance biosynthetic process" ; rdfs:subClassOf obo:GO_0009058, obo:GO_0071704 . obo:GO_1901605 obo:IAO_0000115 "The chemical reactions and pathways involving an alpha-amino acid." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2012-11-08T17:39:50Z" ; oboInOwl:hasExactSynonym "alpha-amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901605" ; a owl:Class ; rdfs:label "alpha-amino acid metabolic process" ; rdfs:subClassOf obo:GO_0006520 . obo:GO_1901615 obo:IAO_0000115 "The chemical reactions and pathways involving organic hydroxy compound." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-13T12:54:27Z" ; oboInOwl:hasExactSynonym "organic hydroxy compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901615" ; a owl:Class ; rdfs:label "organic hydroxy compound metabolic process" ; rdfs:subClassOf obo:GO_0071704 . obo:GO_1901617 obo:IAO_0000115 "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-13T12:54:36Z" ; oboInOwl:hasExactSynonym "organic hydroxy compound anabolism", "organic hydroxy compound biosynthesis", "organic hydroxy compound formation", "organic hydroxy compound synthesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901617" ; a owl:Class ; rdfs:label "organic hydroxy compound biosynthetic process" ; rdfs:subClassOf obo:GO_1901576, obo:GO_1901615 . obo:GO_1901657 obo:IAO_0000115 "The chemical reactions and pathways involving glycosyl compound." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-20T14:24:07Z" ; oboInOwl:hasExactSynonym "glycosyl compound metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901657" ; a owl:Class ; rdfs:label "glycosyl compound metabolic process" ; rdfs:subClassOf obo:GO_1901135 . obo:GO_1901661 obo:IAO_0000115 "The chemical reactions and pathways involving quinone." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-11-20T14:44:39Z" ; oboInOwl:hasAlternativeId "GO:0042375" ; oboInOwl:hasExactSynonym "quinone metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "quinone cofactor metabolic process", "quinone cofactor metabolism" ; oboInOwl:id "GO:1901661" ; a owl:Class ; rdfs:label "quinone metabolic process" ; rdfs:subClassOf obo:GO_0042180 . obo:GO_1901702 obo:IAO_0000115 "Enables the transfer of salt from one side of a membrane to the other." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2012-12-13T15:14:47Z" ; oboInOwl:hasOBONamespace "molecular_function" ; oboInOwl:id "GO:1901702" ; a owl:Class ; rdfs:label "salt transmembrane transporter activity" ; rdfs:subClassOf obo:GO_0022857 . obo:GO_1901731 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-01-10T13:25:39Z" ; oboInOwl:hasExactSynonym "positive regulation of blood platelet aggregation", "up regulation of blood platelet aggregation", "up regulation of platelet aggregation", "up-regulation of blood platelet aggregation", "up-regulation of platelet aggregation", "upregulation of blood platelet aggregation", "upregulation of platelet aggregation" ; oboInOwl:hasNarrowSynonym "activation of blood platelet aggregation", "activation of platelet aggregation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of thrombocyte aggregation", "positive regulation of thrombocyte aggregation", "up regulation of thrombocyte aggregation", "up-regulation of thrombocyte aggregation", "upregulation of thrombocyte aggregation" ; oboInOwl:id "GO:1901731" ; a owl:Class ; rdfs:label "positive regulation of platelet aggregation" ; rdfs:subClassOf obo:GO_0034112, obo:GO_0090330, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070527 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070527 ] ) ] . obo:GO_1901738 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-01-11T15:29:43Z" ; oboInOwl:hasExactSynonym "regulation of vitamin A metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901738" ; a owl:Class ; rdfs:label "regulation of vitamin A metabolic process" ; rdfs:subClassOf obo:GO_0019747, obo:GO_0030656, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006776 ] ) ] . obo:GO_1901858 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2013-02-01T10:05:04Z" ; oboInOwl:hasExactSynonym "regulation of mitochondrial DNA metabolism", "regulation of mtDNA metabolic process", "regulation of mtDNA metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901858" ; a owl:Class ; rdfs:label "regulation of mitochondrial DNA metabolic process" ; rdfs:subClassOf obo:GO_0051052, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032042 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032042 ] ) ] . obo:GO_1901859 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2013-02-01T10:05:09Z" ; oboInOwl:hasExactSynonym "down regulation of mitochondrial DNA metabolic process", "down regulation of mitochondrial DNA metabolism", "down regulation of mtDNA metabolic process", "down regulation of mtDNA metabolism", "down-regulation of mitochondrial DNA metabolic process", "down-regulation of mitochondrial DNA metabolism", "down-regulation of mtDNA metabolic process", "down-regulation of mtDNA metabolism", "downregulation of mitochondrial DNA metabolic process", "downregulation of mitochondrial DNA metabolism", "downregulation of mtDNA metabolic process", "downregulation of mtDNA metabolism", "inhibition of mitochondrial DNA metabolism", "inhibition of mtDNA metabolic process", "inhibition of mtDNA metabolism", "negative regulation of mitochondrial DNA metabolism", "negative regulation of mtDNA metabolic process", "negative regulation of mtDNA metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of mitochondrial DNA metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901859" ; a owl:Class ; rdfs:label "negative regulation of mitochondrial DNA metabolic process" ; rdfs:subClassOf obo:GO_0051053, obo:GO_1901858, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032042 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032042 ] ) ] . obo:GO_1901860 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2013-02-01T10:05:14Z" ; oboInOwl:hasExactSynonym "activation of mitochondrial DNA metabolism", "activation of mtDNA metabolic process", "activation of mtDNA metabolism", "positive regulation of mitochondrial DNA metabolism", "positive regulation of mtDNA metabolic process", "positive regulation of mtDNA metabolism", "up regulation of mitochondrial DNA metabolic process", "up regulation of mitochondrial DNA metabolism", "up regulation of mtDNA metabolic process", "up regulation of mtDNA metabolism", "up-regulation of mitochondrial DNA metabolic process", "up-regulation of mitochondrial DNA metabolism", "up-regulation of mtDNA metabolic process", "up-regulation of mtDNA metabolism", "upregulation of mitochondrial DNA metabolic process", "upregulation of mitochondrial DNA metabolism", "upregulation of mtDNA metabolic process", "upregulation of mtDNA metabolism" ; oboInOwl:hasNarrowSynonym "activation of mitochondrial DNA metabolic process" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1901860" ; a owl:Class ; rdfs:label "positive regulation of mitochondrial DNA metabolic process" ; rdfs:subClassOf obo:GO_0010822, obo:GO_0051054, obo:GO_1901858, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032042 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032042 ] ) ] . obo:GO_1902017 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cilium assembly." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-03-26T18:10:51Z" ; oboInOwl:hasExactSynonym "regulation of ciliogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cilium biogenesis" ; oboInOwl:id "GO:1902017" ; a owl:Class ; rdfs:label "regulation of cilium assembly" ; rdfs:subClassOf obo:GO_0120032, obo:GO_1902115, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060271 ] ) ] . obo:GO_1902018 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-03-26T18:10:56Z" ; oboInOwl:hasExactSynonym "down regulation of ciliogenesis", "down regulation of cilium assembly", "down-regulation of ciliogenesis", "down-regulation of cilium assembly", "downregulation of ciliogenesis", "downregulation of cilium assembly", "inhibition of ciliogenesis", "negative regulation of ciliogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of cilium assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of cilium biogenesis", "down-regulation of cilium biogenesis", "downregulation of cilium biogenesis", "inhibition of cilium biogenesis", "negative regulation of cilium biogenesis" ; oboInOwl:id "GO:1902018" ; a owl:Class ; rdfs:label "negative regulation of cilium assembly" ; rdfs:subClassOf obo:GO_0120033, obo:GO_1902017, obo:GO_1902116, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060271 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060271 ] ) ] . obo:GO_1902019 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-03-27T14:42:38Z" ; oboInOwl:hasExactSynonym "regulation of cilium cell motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of ciliary cell motility" ; oboInOwl:id "GO:1902019" ; a owl:Class ; rdfs:label "regulation of cilium-dependent cell motility" ; rdfs:subClassOf obo:GO_2000145, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060285 ] ) ] . obo:GO_1902020 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2013-03-27T14:42:42Z" ; oboInOwl:hasExactSynonym "down regulation of ciliary cell motility", "down-regulation of ciliary cell motility", "downregulation of ciliary cell motility", "negative regulation of cilium cell motility" ; oboInOwl:hasNarrowSynonym "inhibition of ciliary cell motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of ciliary cell motility" ; oboInOwl:id "GO:1902020" ; a owl:Class ; rdfs:label "negative regulation of cilium-dependent cell motility" ; rdfs:subClassOf obo:GO_1902019, obo:GO_2000146, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060285 ] ) ] . obo:GO_1902093 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2013-04-29T09:15:25Z" ; oboInOwl:hasBroadSynonym "activation of sperm movement", "positive regulation of sperm motility", "positive regulation of sperm movement", "up regulation of sperm motility", "up regulation of sperm movement", "up-regulation of sperm motility", "up-regulation of sperm movement", "upregulation of sperm motility", "upregulation of sperm movement" ; oboInOwl:hasNarrowSynonym "activation of sperm motility" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902093" ; a owl:Class ; rdfs:label "positive regulation of flagellated sperm motility" ; rdfs:subClassOf obo:GO_0003353, obo:GO_1901317, obo:GO_2000155, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030317 ] ) ] . obo:GO_1902105 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of leukocyte differentiation." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-02T17:32:42Z" ; oboInOwl:hasExactSynonym "regulation of immune cell differentiation", "regulation of leucocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902105" ; a owl:Class ; rdfs:label "regulation of leukocyte differentiation" ; rdfs:subClassOf obo:GO_1903706, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002521 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002521 ] ) ] . obo:GO_1902106 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-02T17:32:47Z" ; oboInOwl:hasExactSynonym "down regulation of immune cell differentiation", "down regulation of leucocyte differentiation", "down regulation of leukocyte differentiation", "down-regulation of immune cell differentiation", "down-regulation of leucocyte differentiation", "down-regulation of leukocyte differentiation", "downregulation of immune cell differentiation", "downregulation of leucocyte differentiation", "downregulation of leukocyte differentiation", "negative regulation of immune cell differentiation", "negative regulation of leucocyte differentiation" ; oboInOwl:hasNarrowSynonym "inhibition of immune cell differentiation", "inhibition of leucocyte differentiation", "inhibition of leukocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902106" ; a owl:Class ; rdfs:label "negative regulation of leukocyte differentiation" ; rdfs:subClassOf obo:GO_1902105, obo:GO_1903707, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002521 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002521 ] ) ] . obo:GO_1902107 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-02T17:32:52Z" ; oboInOwl:hasExactSynonym "positive regulation of immune cell differentiation", "positive regulation of leucocyte differentiation", "up regulation of immune cell differentiation", "up regulation of leucocyte differentiation", "up regulation of leukocyte differentiation", "up-regulation of immune cell differentiation", "up-regulation of leucocyte differentiation", "up-regulation of leukocyte differentiation", "upregulation of immune cell differentiation", "upregulation of leucocyte differentiation", "upregulation of leukocyte differentiation" ; oboInOwl:hasNarrowSynonym "activation of immune cell differentiation", "activation of leucocyte differentiation", "activation of leukocyte differentiation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902107" ; a owl:Class ; rdfs:label "positive regulation of leukocyte differentiation" ; rdfs:subClassOf obo:GO_1902105, obo:GO_1903708, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002521 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002521 ] ) ] . obo:GO_1902115 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of organelle assembly." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-14T09:43:21Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902115" ; a owl:Class ; rdfs:label "regulation of organelle assembly" ; rdfs:subClassOf obo:GO_0033043, obo:GO_0044087, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070925 ] ) ] . obo:GO_1902116 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-14T09:43:31Z" ; oboInOwl:hasExactSynonym "down regulation of organelle assembly", "down-regulation of organelle assembly", "downregulation of organelle assembly" ; oboInOwl:hasNarrowSynonym "inhibition of organelle assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902116" ; a owl:Class ; rdfs:label "negative regulation of organelle assembly" ; rdfs:subClassOf obo:GO_0010639, obo:GO_1902115, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070925 ] ) ] . obo:GO_1902117 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of organelle assembly." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-05-14T09:43:36Z" ; oboInOwl:hasExactSynonym "up regulation of organelle assembly", "up-regulation of organelle assembly", "upregulation of organelle assembly" ; oboInOwl:hasNarrowSynonym "activation of organelle assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902117" ; a owl:Class ; rdfs:label "positive regulation of organelle assembly" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0044089, obo:GO_1902115, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070925 ] ) ] . obo:GO_1902221 obo:IAO_0000115 "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-06-13T10:37:38Z" ; oboInOwl:hasExactSynonym "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902221" ; a owl:Class ; rdfs:label "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process" ; rdfs:subClassOf obo:GO_1901605 . obo:GO_1902224 obo:IAO_0000115 "The chemical reactions and pathways involving ketone body." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2013-06-13T10:37:54Z" ; oboInOwl:hasExactSynonym "ketone body metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902224" ; a owl:Class ; rdfs:label "ketone body metabolic process" ; rdfs:subClassOf obo:GO_0006091, obo:GO_1901568 . obo:GO_1902262 obo:IAO_0000115 "Any apoptotic process that is involved in blood vessel morphogenesis." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2013-06-25T16:16:00Z" ; oboInOwl:hasExactSynonym "apoptotic cell death involved in patterning of blood vessels", "apoptotic programmed cell death involved in patterning of blood vessels", "programmed cell death by apoptosis involved in patterning of blood vessels" ; oboInOwl:hasNarrowSynonym "apoptosis involved in patterning of blood vessels", "apoptotic program involved in patterning of blood vessels", "type I programmed cell death involved in patterning of blood vessels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "signaling (initiator) caspase activity involved in patterning of blood vessels" ; oboInOwl:id "GO:1902262" ; a owl:Class ; rdfs:label "apoptotic process involved in blood vessel morphogenesis" ; rdfs:subClassOf obo:GO_0060561, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048514 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048514 ] ) ] . obo:GO_1902275 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of chromatin organization." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2013-07-01T13:21:52Z" ; oboInOwl:hasAlternativeId "GO:0001672", "GO:1903308" ; oboInOwl:hasExactSynonym "regulation of chromatin organisation", "regulation of establishment or maintenance of chromatin architecture" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of chromatin assembly or disassembly", "regulation of chromatin assembly/disassembly", "regulation of chromatin modification" ; oboInOwl:id "GO:1902275" ; a owl:Class ; rdfs:label "regulation of chromatin organization" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006325 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006325 ] ) ] . obo:GO_1902337 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." ; oboInOwl:created_by "sart" ; oboInOwl:creation_date "2013-07-29T15:03:16Z" ; oboInOwl:hasNarrowSynonym "regulation of apoptosis involved in morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of apoptosis involved in development", "regulation of morphogenetic apoptosis" ; oboInOwl:id "GO:1902337" ; a owl:Class ; rdfs:label "regulation of apoptotic process involved in morphogenesis" ; rdfs:subClassOf obo:GO_1904748, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060561 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060561 ] ) ] . obo:GO_1902338 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." ; oboInOwl:created_by "sart" ; oboInOwl:creation_date "2013-07-29T15:03:25Z" ; oboInOwl:hasExactSynonym "down regulation of apoptotic process involved in morphogenesis", "down-regulation of apoptotic process involved in morphogenesis", "downregulation of apoptotic process involved in morphogenesis" ; oboInOwl:hasNarrowSynonym "down regulation of apoptosis involved in morphogenesis", "down-regulation of apoptosis involved in morphogenesis", "downregulation of apoptosis involved in morphogenesis", "inhibition of apoptosis involved in morphogenesis", "inhibition of apoptotic process involved in morphogenesis", "negative regulation of apoptosis involved in morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of apoptosis involved in development", "down regulation of morphogenetic apoptosis", "down-regulation of apoptosis involved in development", "down-regulation of morphogenetic apoptosis", "downregulation of apoptosis involved in development", "downregulation of morphogenetic apoptosis", "inhibition of apoptosis involved in development", "inhibition of morphogenetic apoptosis", "negative regulation of apoptosis involved in development", "negative regulation of morphogenetic apoptosis" ; oboInOwl:id "GO:1902338" ; a owl:Class ; rdfs:label "negative regulation of apoptotic process involved in morphogenesis" ; rdfs:subClassOf obo:GO_1902337, obo:GO_1904746, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060561 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060561 ] ) ] . obo:GO_1902339 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." ; oboInOwl:created_by "sart" ; oboInOwl:creation_date "2013-07-29T15:03:33Z" ; oboInOwl:hasExactSynonym "up regulation of apoptotic process involved in morphogenesis", "up-regulation of apoptotic process involved in morphogenesis", "upregulation of apoptotic process involved in morphogenesis" ; oboInOwl:hasNarrowSynonym "activation of apoptosis involved in morphogenesis", "activation of apoptotic process involved in morphogenesis", "positive regulation of apoptosis involved in morphogenesis", "up regulation of apoptosis involved in morphogenesis", "up-regulation of apoptosis involved in morphogenesis", "upregulation of apoptosis involved in morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of apoptosis involved in development", "activation of morphogenetic apoptosis", "positive regulation of apoptosis involved in development", "positive regulation of morphogenetic apoptosis", "up regulation of apoptosis involved in development", "up regulation of morphogenetic apoptosis", "up-regulation of apoptosis involved in development", "up-regulation of morphogenetic apoptosis", "upregulation of apoptosis involved in development", "upregulation of morphogenetic apoptosis" ; oboInOwl:id "GO:1902339" ; a owl:Class ; rdfs:label "positive regulation of apoptotic process involved in morphogenesis" ; rdfs:subClassOf obo:GO_1902337, obo:GO_1904747, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060561 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060561 ] ) ] . obo:GO_1902340 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." ; oboInOwl:created_by "dgf" ; oboInOwl:creation_date "2013-07-29T20:54:14Z" ; oboInOwl:hasExactSynonym "down regulation of chromosome condensation", "down regulation of eukaryotic chromosome condensation", "down regulation of nuclear chromosome condensation", "down-regulation of chromosome condensation", "down-regulation of eukaryotic chromosome condensation", "down-regulation of nuclear chromosome condensation", "downregulation of chromosome condensation", "downregulation of eukaryotic chromosome condensation", "downregulation of nuclear chromosome condensation", "negative regulation of eukaryotic chromosome condensation", "negative regulation of nuclear chromosome condensation" ; oboInOwl:hasNarrowSynonym "inhibition of chromosome condensation", "inhibition of eukaryotic chromosome condensation", "inhibition of nuclear chromosome condensation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902340" ; a owl:Class ; rdfs:label "negative regulation of chromosome condensation" ; rdfs:subClassOf obo:GO_0060623, obo:GO_2001251, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030261 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030261 ] ) ] . obo:GO_1902490 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sperm capacitation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2013-11-12T21:17:03Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of sperm activation" ; oboInOwl:id "GO:1902490" ; a owl:Class ; rdfs:label "regulation of sperm capacitation" ; rdfs:subClassOf obo:GO_0051239, obo:GO_1903429, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048240 ] ) ] . obo:GO_1902491 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2013-11-12T21:17:12Z" ; oboInOwl:hasExactSynonym "down regulation of sperm capacitation", "down-regulation of sperm capacitation", "downregulation of sperm capacitation" ; oboInOwl:hasNarrowSynonym "inhibition of sperm capacitation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of sperm activation", "down-regulation of sperm activation", "downregulation of sperm activation", "inhibition of sperm activation", "negative regulation of sperm activation" ; oboInOwl:id "GO:1902491" ; a owl:Class ; rdfs:label "negative regulation of sperm capacitation" ; rdfs:subClassOf obo:GO_0051241, obo:GO_1902490, obo:GO_1903430, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048240 ] ) ] . obo:GO_1902492 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of sperm capacitation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2013-11-12T21:17:21Z" ; oboInOwl:hasExactSynonym "up regulation of sperm capacitation", "up-regulation of sperm capacitation", "upregulation of sperm capacitation" ; oboInOwl:hasNarrowSynonym "activation of sperm capacitation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of sperm activation", "positive regulation of sperm activation", "up regulation of sperm activation", "up-regulation of sperm activation", "upregulation of sperm activation" ; oboInOwl:id "GO:1902492" ; a owl:Class ; rdfs:label "positive regulation of sperm capacitation" ; rdfs:subClassOf obo:GO_0051240, obo:GO_1902490, obo:GO_1903431, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048240 ] ) ] . obo:GO_1902494 obo:IAO_0000115 "A protein complex which is capable of catalytic activity." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/19980"^^xsd:anyURI ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2013-11-13T16:18:47Z" ; oboInOwl:hasExactSynonym "enzyme complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:1902494" ; oboInOwl:inSubset go:goslim_metagenomics ; a owl:Class ; rdfs:label "catalytic complex" ; rdfs:subClassOf obo:GO_0032991 . obo:GO_1902531 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of intracellular signal transduction." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2013-12-02T11:32:52Z" ; oboInOwl:hasAlternativeId "GO:0010627" ; oboInOwl:hasExactSynonym "regulation of intracellular signaling cascade", "regulation of intracellular signaling chain" ; oboInOwl:hasNarrowSynonym "regulation of intracellular protein kinase cascade", "regulation of intracellular signal transduction pathway", "regulation of signal transmission via intracellular cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of intracellular signaling pathway", "regulation of signal transduction via intracellular signaling cascade" ; oboInOwl:id "GO:1902531" ; a owl:Class ; rdfs:label "regulation of intracellular signal transduction" ; rdfs:subClassOf obo:GO_0009966, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035556 ] ) ] . obo:GO_1902532 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2013-12-02T11:33:01Z" ; oboInOwl:hasAlternativeId "GO:0010741" ; oboInOwl:hasExactSynonym "down regulation of intracellular signal transduction", "down regulation of intracellular signaling chain", "down-regulation of intracellular signal transduction", "down-regulation of intracellular signaling chain", "downregulation of intracellular signal transduction", "downregulation of intracellular signaling chain", "negative regulation of intracellular protein kinase cascade", "negative regulation of intracellular signaling cascade", "negative regulation of intracellular signaling chain" ; oboInOwl:hasNarrowSynonym "down regulation of intracellular signal transduction pathway", "down regulation of intracellular signaling cascade", "down regulation of signal transmission via intracellular cascade", "down-regulation of intracellular signal transduction pathway", "downregulation of intracellular signal transduction pathway", "downregulation of intracellular signaling cascade", "downregulation of signal transmission via intracellular cascade", "inhibition of intracellular signal transduction", "inhibition of intracellular signal transduction pathway", "inhibition of intracellular signaling cascade", "inhibition of intracellular signaling chain", "inhibition of signal transmission via intracellular cascade", "negative regulation of intracellular signal transduction pathway", "negative regulation of signal transmission via intracellular cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of intracellular signaling pathway", "down regulation of signal transduction via intracellular signaling cascade", "down-regulation of intracellular signaling cascade", "down-regulation of intracellular signaling pathway", "down-regulation of signal transduction via intracellular signaling cascade", "down-regulation of signal transmission via intracellular cascade", "downregulation of intracellular signaling pathway", "downregulation of signal transduction via intracellular signaling cascade", "inhibition of intracellular signaling pathway", "inhibition of signal transduction via intracellular signaling cascade", "negative regulation of intracellular signaling pathway", "negative regulation of signal transduction via intracellular signaling cascade" ; oboInOwl:id "GO:1902532" ; a owl:Class ; rdfs:label "negative regulation of intracellular signal transduction" ; rdfs:subClassOf obo:GO_0009968, obo:GO_1902531, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035556 ] ) ] . obo:GO_1902533 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2013-12-02T11:33:10Z" ; oboInOwl:hasAlternativeId "GO:0010740" ; oboInOwl:hasExactSynonym "positive regulation of intracellular signaling chain", "up regulation of intracellular signal transduction", "up regulation of intracellular signaling chain", "up-regulation of intracellular signal transduction", "up-regulation of intracellular signaling chain", "upregulation of intracellular signal transduction", "upregulation of intracellular signaling chain" ; oboInOwl:hasNarrowSynonym "activation of intracellular signal transduction", "activation of intracellular signal transduction pathway", "activation of intracellular signaling cascade", "activation of intracellular signaling chain", "activation of signal transmission via intracellular cascade", "positive regulation of intracellular protein kinase cascade", "positive regulation of intracellular signal transduction pathway", "positive regulation of signal transmission via intracellular cascade", "up regulation of intracellular signal transduction pathway", "up regulation of signal transmission via intracellular cascade", "up-regulation of intracellular signal transduction pathway", "up-regulation of signal transmission via intracellular cascade", "upregulation of intracellular signal transduction pathway", "upregulation of signal transmission via intracellular cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of intracellular signaling pathway", "activation of signal transduction via intracellular signaling cascade", "positive regulation of intracellular signaling cascade", "positive regulation of intracellular signaling pathway", "positive regulation of signal transduction via intracellular signaling cascade", "up regulation of intracellular signaling cascade", "up regulation of intracellular signaling pathway", "up regulation of signal transduction via intracellular signaling cascade", "up-regulation of intracellular signaling cascade", "up-regulation of intracellular signaling pathway", "up-regulation of signal transduction via intracellular signaling cascade", "upregulation of intracellular signaling cascade", "upregulation of intracellular signaling pathway", "upregulation of signal transduction via intracellular signaling cascade" ; oboInOwl:id "GO:1902533" ; a owl:Class ; rdfs:label "positive regulation of intracellular signal transduction" ; rdfs:subClassOf obo:GO_0009967, obo:GO_1902531, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035556 ] ) ] . obo:GO_1902622 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of neutrophil migration." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2014-01-15T18:58:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902622" ; a owl:Class ; rdfs:label "regulation of neutrophil migration" ; rdfs:subClassOf obo:GO_0002685, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1990266 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1990266 ] ) ] . obo:GO_1902623 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2014-01-15T18:58:49Z" ; oboInOwl:hasExactSynonym "down regulation of neutrophil migration", "down-regulation of neutrophil migration", "downregulation of neutrophil migration" ; oboInOwl:hasNarrowSynonym "inhibition of neutrophil migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902623" ; a owl:Class ; rdfs:label "negative regulation of neutrophil migration" ; rdfs:subClassOf obo:GO_0002686, obo:GO_1902622, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1990266 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1990266 ] ) ] . obo:GO_1902624 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of neutrophil migration." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2014-01-15T18:58:58Z" ; oboInOwl:hasExactSynonym "up regulation of neutrophil migration", "up-regulation of neutrophil migration", "upregulation of neutrophil migration" ; oboInOwl:hasNarrowSynonym "activation of neutrophil migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902624" ; a owl:Class ; rdfs:label "positive regulation of neutrophil migration" ; rdfs:subClassOf obo:GO_0002687, obo:GO_1902622, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1990266 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1990266 ] ) ] . obo:GO_1902652 obo:IAO_0000115 "The chemical reactions and pathways involving secondary alcohol." ; oboInOwl:created_by "tt" ; oboInOwl:creation_date "2014-01-22T10:14:52Z" ; oboInOwl:hasExactSynonym "secondary alcohol metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902652" ; a owl:Class ; rdfs:label "secondary alcohol metabolic process" ; rdfs:subClassOf obo:GO_0006066 . obo:GO_1902721 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-02-24T16:09:28Z" ; oboInOwl:hasExactSynonym "down regulation of prolactin secretion", "down-regulation of prolactin secretion", "downregulation of prolactin secretion" ; oboInOwl:hasNarrowSynonym "inhibition of prolactin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902721" ; a owl:Class ; rdfs:label "negative regulation of prolactin secretion" ; rdfs:subClassOf obo:GO_0050709, obo:GO_0090278, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070459 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070459 ] ) ] . obo:GO_1902722 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of prolactin secretion." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-02-24T16:09:37Z" ; oboInOwl:hasExactSynonym "up regulation of prolactin secretion", "up-regulation of prolactin secretion", "upregulation of prolactin secretion" ; oboInOwl:hasNarrowSynonym "activation of prolactin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1902722" ; a owl:Class ; rdfs:label "positive regulation of prolactin secretion" ; rdfs:subClassOf obo:GO_0050714, obo:GO_0090277, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070459 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070459 ] ) ] . obo:GO_1902742 obo:IAO_0000115 "Any apoptotic process that is involved in anatomical structure development." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2014-02-28T13:09:43Z" ; oboInOwl:hasExactSynonym "apoptotic cell death involved in anatomical structure development", "apoptotic cell death involved in development of an anatomical structure", "apoptotic process involved in anatomical structure development", "apoptotic process involved in development of an anatomical structure", "apoptotic programmed cell death involved in anatomical structure development", "apoptotic programmed cell death involved in development of an anatomical structure", "programmed cell death by apoptosis involved in anatomical structure development", "programmed cell death by apoptosis involved in development of an anatomical structure" ; oboInOwl:hasNarrowSynonym "activation of apoptosis involved in anatomical structure development", "activation of apoptosis involved in development of an anatomical structure", "apoptosis involved in anatomical structure development", "apoptosis involved in development of an anatomical structure", "apoptosis signaling involved in anatomical structure development", "apoptosis signaling involved in development of an anatomical structure", "apoptotic program involved in anatomical structure development", "apoptotic program involved in development of an anatomical structure", "type I programmed cell death involved in anatomical structure development", "type I programmed cell death involved in development of an anatomical structure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "apoptosis activator activity involved in anatomical structure development", "apoptosis activator activity involved in development of an anatomical structure", "commitment to apoptosis involved in anatomical structure development", "commitment to apoptosis involved in development of an anatomical structure", "induction of apoptosis by p53 involved in anatomical structure development", "induction of apoptosis by p53 involved in development of an anatomical structure", "induction of apoptosis involved in anatomical structure development", "induction of apoptosis involved in development of an anatomical structure", "signaling (initiator) caspase activity involved in anatomical structure development", "signaling (initiator) caspase activity involved in development of an anatomical structure" ; oboInOwl:id "GO:1902742" ; a owl:Class ; rdfs:label "apoptotic process involved in development" ; rdfs:subClassOf obo:GO_0006915, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048856 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0048856 ] ) ] . obo:GO_1902850 obo:IAO_0000115 "Any microtubule cytoskeleton organization that is involved in mitosis." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2014-04-02T14:19:38Z" ; oboInOwl:hasExactSynonym "microtubule cytoskeleton organisation involved in mitosis", "microtubule dynamics involved in mitosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "microtubule cytoskeleton organization and biogenesis involved in mitosis" ; oboInOwl:id "GO:1902850" ; a owl:Class ; rdfs:label "microtubule cytoskeleton organization involved in mitosis" ; rdfs:subClassOf obo:GO_0000226, obo:GO_1903047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0000226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_1903010 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bone development." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-05-13T22:41:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903010" ; a owl:Class ; rdfs:label "regulation of bone development" ; rdfs:subClassOf obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060348 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060348 ] ) ] . obo:GO_1903011 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-05-13T22:42:00Z" ; oboInOwl:hasExactSynonym "down regulation of bone development", "down-regulation of bone development", "downregulation of bone development" ; oboInOwl:hasNarrowSynonym "inhibition of bone development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903011" ; a owl:Class ; rdfs:label "negative regulation of bone development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_1903010, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060348 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060348 ] ) ] . obo:GO_1903012 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bone development." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-05-13T22:42:06Z" ; oboInOwl:hasExactSynonym "up regulation of bone development", "up-regulation of bone development", "upregulation of bone development" ; oboInOwl:hasNarrowSynonym "activation of bone development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903012" ; a owl:Class ; rdfs:label "positive regulation of bone development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0051240, obo:GO_1903010, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060348 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060348 ] ) ] . obo:GO_1903018 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-14T18:44:19Z" ; oboInOwl:hasExactSynonym "regulation of glycoprotein metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903018" ; a owl:Class ; rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ; rdfs:label "regulation of glycoprotein metabolic process" ; rdfs:subClassOf obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009100 ] ) ] . obo:GO_1903019 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-14T18:44:25Z" ; oboInOwl:hasExactSynonym "down regulation of glycoprotein metabolic process", "down regulation of glycoprotein metabolism", "down-regulation of glycoprotein metabolic process", "down-regulation of glycoprotein metabolism", "downregulation of glycoprotein metabolic process", "downregulation of glycoprotein metabolism", "negative regulation of glycoprotein metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of glycoprotein metabolic process", "inhibition of glycoprotein metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903019" ; a owl:Class ; rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ; rdfs:label "negative regulation of glycoprotein metabolic process" ; rdfs:subClassOf obo:GO_0051248, obo:GO_1903018, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009100 ] ) ] . obo:GO_1903020 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-14T18:44:31Z" ; oboInOwl:hasExactSynonym "positive regulation of glycoprotein metabolism", "up regulation of glycoprotein metabolic process", "up regulation of glycoprotein metabolism", "up-regulation of glycoprotein metabolic process", "up-regulation of glycoprotein metabolism", "upregulation of glycoprotein metabolic process", "upregulation of glycoprotein metabolism" ; oboInOwl:hasNarrowSynonym "activation of glycoprotein metabolic process", "activation of glycoprotein metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903020" ; a owl:Class ; rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ; rdfs:label "positive regulation of glycoprotein metabolic process" ; rdfs:subClassOf obo:GO_0051247, obo:GO_1903018, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009100 ] ) ] . obo:GO_1903034 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of response to wounding." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2014-05-18T01:28:46Z" ; oboInOwl:hasExactSynonym "regulation of physiological response to wounding" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903034" ; a owl:Class ; rdfs:label "regulation of response to wounding" ; rdfs:subClassOf obo:GO_0080134, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009611 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009611 ] ) ] . obo:GO_1903035 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2014-05-18T01:28:52Z" ; oboInOwl:hasExactSynonym "down regulation of physiological response to wounding", "down regulation of response to wounding", "down-regulation of physiological response to wounding", "down-regulation of response to wounding", "downregulation of physiological response to wounding", "downregulation of response to wounding", "negative regulation of physiological response to wounding" ; oboInOwl:hasNarrowSynonym "inhibition of physiological response to wounding", "inhibition of response to wounding" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903035" ; a owl:Class ; rdfs:label "negative regulation of response to wounding" ; rdfs:subClassOf obo:GO_0048585, obo:GO_1903034, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009611 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0009611 ] ) ] . obo:GO_1903036 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of response to wounding." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2014-05-18T01:28:58Z" ; oboInOwl:hasExactSynonym "positive regulation of physiological response to wounding", "up regulation of physiological response to wounding", "up regulation of response to wounding", "up-regulation of physiological response to wounding", "up-regulation of response to wounding", "upregulation of physiological response to wounding", "upregulation of response to wounding" ; oboInOwl:hasNarrowSynonym "activation of physiological response to wounding", "activation of response to wounding" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903036" ; a owl:Class ; rdfs:label "positive regulation of response to wounding" ; rdfs:subClassOf obo:GO_0048584, obo:GO_1903034, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009611 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009611 ] ) ] . obo:GO_1903037 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-19T15:29:58Z" ; oboInOwl:hasExactSynonym "regulation of leukocyte adhesion", "regulation of leukocyte cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903037" ; a owl:Class ; rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ; rdfs:label "regulation of leukocyte cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022407, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007159 ] ) ] . obo:GO_1903038 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-19T15:30:05Z" ; oboInOwl:hasExactSynonym "down regulation of leukocyte adhesion", "down regulation of leukocyte cell adhesion", "down regulation of leukocyte cell-cell adhesion", "down-regulation of leukocyte adhesion", "down-regulation of leukocyte cell adhesion", "down-regulation of leukocyte cell-cell adhesion", "downregulation of leukocyte adhesion", "downregulation of leukocyte cell adhesion", "downregulation of leukocyte cell-cell adhesion", "negative regulation of leukocyte adhesion", "negative regulation of leukocyte cell adhesion" ; oboInOwl:hasNarrowSynonym "inhibition of leukocyte adhesion", "inhibition of leukocyte cell adhesion", "inhibition of leukocyte cell-cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903038" ; a owl:Class ; rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ; rdfs:label "negative regulation of leukocyte cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022408, obo:GO_1903037, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007159 ] ) ] . obo:GO_1903039 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-19T15:30:15Z" ; oboInOwl:hasExactSynonym "positive regulation of leukocyte adhesion", "positive regulation of leukocyte cell adhesion", "up regulation of leukocyte adhesion", "up regulation of leukocyte cell adhesion", "up regulation of leukocyte cell-cell adhesion", "up-regulation of leukocyte adhesion", "up-regulation of leukocyte cell adhesion", "up-regulation of leukocyte cell-cell adhesion", "upregulation of leukocyte adhesion", "upregulation of leukocyte cell adhesion", "upregulation of leukocyte cell-cell adhesion" ; oboInOwl:hasNarrowSynonym "activation of leukocyte adhesion", "activation of leukocyte cell adhesion", "activation of leukocyte cell-cell adhesion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903039" ; a owl:Class ; rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ; rdfs:label "positive regulation of leukocyte cell-cell adhesion" ; rdfs:subClassOf obo:GO_0022409, obo:GO_1903037, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007159 ] ) ] . obo:GO_1903046 obo:IAO_0000115 "A process that is part of the meiotic cell cycle." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-05-22T14:22:28Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903046" ; oboInOwl:inSubset go:gocheck_do_not_annotate, go:goslim_pombe ; a owl:Class ; rdfs:label "meiotic cell cycle process" ; rdfs:subClassOf obo:GO_0022402, obo:GO_0022414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ; owl:disjointWith obo:GO_1903047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0051321 ] ) ] . obo:GO_1903047 obo:IAO_0000115 "A process that is part of the mitotic cell cycle." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-05-22T14:22:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903047" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "mitotic cell cycle process" ; rdfs:subClassOf obo:GO_0022402, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000278 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0009987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0000278 ] ) ] . obo:GO_1903053 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of extracellular matrix organization." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-23T17:15:41Z" ; oboInOwl:hasExactSynonym "regulation of extracellular matrix organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of extracellular matrix organization and biogenesis" ; oboInOwl:id "GO:1903053" ; a owl:Class ; rdfs:label "regulation of extracellular matrix organization" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030198 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030198 ] ) ] . obo:GO_1903054 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-23T17:15:47Z" ; oboInOwl:hasExactSynonym "down regulation of extracellular matrix organisation", "down regulation of extracellular matrix organization", "down-regulation of extracellular matrix organisation", "down-regulation of extracellular matrix organization", "downregulation of extracellular matrix organisation", "downregulation of extracellular matrix organization", "negative regulation of extracellular matrix organisation" ; oboInOwl:hasNarrowSynonym "inhibition of extracellular matrix organisation", "inhibition of extracellular matrix organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of extracellular matrix organization and biogenesis", "down-regulation of extracellular matrix organization and biogenesis", "downregulation of extracellular matrix organization and biogenesis", "inhibition of extracellular matrix organization and biogenesis", "negative regulation of extracellular matrix organization and biogenesis" ; oboInOwl:id "GO:1903054" ; a owl:Class ; rdfs:label "negative regulation of extracellular matrix organization" ; rdfs:subClassOf obo:GO_0051129, obo:GO_1903053, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030198 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030198 ] ) ] . obo:GO_1903055 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2014-05-23T17:15:53Z" ; oboInOwl:hasExactSynonym "positive regulation of extracellular matrix organisation", "up regulation of extracellular matrix organisation", "up regulation of extracellular matrix organization", "up-regulation of extracellular matrix organisation", "up-regulation of extracellular matrix organization", "upregulation of extracellular matrix organisation", "upregulation of extracellular matrix organization" ; oboInOwl:hasNarrowSynonym "activation of extracellular matrix organisation", "activation of extracellular matrix organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of extracellular matrix organization and biogenesis", "positive regulation of extracellular matrix organization and biogenesis", "up regulation of extracellular matrix organization and biogenesis", "up-regulation of extracellular matrix organization and biogenesis", "upregulation of extracellular matrix organization and biogenesis" ; oboInOwl:id "GO:1903055" ; a owl:Class ; rdfs:label "positive regulation of extracellular matrix organization" ; rdfs:subClassOf obo:GO_0051130, obo:GO_1903053, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030198 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030198 ] ) ] . obo:GO_1903131 obo:IAO_0000115 "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." ; oboInOwl:created_by "cls" ; oboInOwl:creation_date "2014-06-25T15:47:09Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903131" ; a owl:Class ; rdfs:label "mononuclear cell differentiation" ; rdfs:subClassOf obo:GO_0002521 . obo:GO_1903294 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-08-13T13:54:15Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903294" ; a owl:Class ; rdfs:comment "An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype" ; rdfs:label "regulation of glutamate secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0014048, obo:GO_0046928, obo:GO_0051966, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0061535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:GO_1903295 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-08-13T13:54:23Z" ; oboInOwl:hasExactSynonym "down regulation of glutamate secretion, neurotransmission", "down-regulation of glutamate secretion, neurotransmission", "downregulation of glutamate secretion, neurotransmission" ; oboInOwl:hasNarrowSynonym "inhibition of glutamate secretion, neurotransmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903295" ; a owl:Class ; rdfs:comment "An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype" ; rdfs:label "negative regulation of glutamate secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0014050, obo:GO_0046929, obo:GO_0051967, obo:GO_1903294, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0061535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:GO_1903296 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-08-13T13:54:31Z" ; oboInOwl:hasExactSynonym "up regulation of glutamate secretion, neurotransmission", "up-regulation of glutamate secretion, neurotransmission", "upregulation of glutamate secretion, neurotransmission" ; oboInOwl:hasNarrowSynonym "activation of glutamate secretion, neurotransmission" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903296" ; a owl:Class ; rdfs:comment "An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype" ; rdfs:label "positive regulation of glutamate secretion, neurotransmission" ; rdfs:subClassOf obo:GO_0001956, obo:GO_0014049, obo:GO_0051968, obo:GO_1903294, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0061535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0061535 ] ) ] . obo:GO_1903317 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein maturation." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2014-08-18T12:59:07Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903317" ; a owl:Class ; rdfs:label "regulation of protein maturation" ; rdfs:subClassOf obo:GO_0010468, obo:GO_0051246, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0051604 ] ) ] . obo:GO_1903318 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2014-08-18T12:59:15Z" ; oboInOwl:hasExactSynonym "down regulation of protein maturation", "down-regulation of protein maturation", "downregulation of protein maturation" ; oboInOwl:hasNarrowSynonym "inhibition of protein maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903318" ; a owl:Class ; rdfs:label "negative regulation of protein maturation" ; rdfs:subClassOf obo:GO_0010629, obo:GO_0051248, obo:GO_1903317, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051604 ] ) ] . obo:GO_1903319 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of protein maturation." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2014-08-18T12:59:23Z" ; oboInOwl:hasExactSynonym "up regulation of protein maturation", "up-regulation of protein maturation", "upregulation of protein maturation" ; oboInOwl:hasNarrowSynonym "activation of protein maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903319" ; a owl:Class ; rdfs:label "positive regulation of protein maturation" ; rdfs:subClassOf obo:GO_0010628, obo:GO_0051247, obo:GO_1903317, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051604 ] ) ] . obo:GO_1903353 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of nucleus organization." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2014-08-20T19:36:16Z" ; oboInOwl:hasExactSynonym "regulation of nuclear organisation", "regulation of nuclear organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of nuclear morphology", "regulation of nuclear organization and biogenesis", "regulation of nucleus organization and biogenesis" ; oboInOwl:id "GO:1903353" ; a owl:Class ; rdfs:label "regulation of nucleus organization" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006997 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006997 ] ) ] . obo:GO_1903379 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." ; oboInOwl:created_by "al" ; oboInOwl:creation_date "2014-08-26T13:57:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903379" ; a owl:Class ; rdfs:label "regulation of mitotic chromosome condensation" ; rdfs:subClassOf obo:GO_0010564, obo:GO_0060623, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007076 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007076 ] ) ] . obo:GO_1903380 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." ; oboInOwl:created_by "al" ; oboInOwl:creation_date "2014-08-26T13:57:29Z" ; oboInOwl:hasExactSynonym "up regulation of mitotic chromosome condensation", "up-regulation of mitotic chromosome condensation", "upregulation of mitotic chromosome condensation" ; oboInOwl:hasNarrowSynonym "activation of mitotic chromosome condensation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903380" ; a owl:Class ; rdfs:label "positive regulation of mitotic chromosome condensation" ; rdfs:subClassOf obo:GO_0090068, obo:GO_1903379, obo:GO_1905821, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007076 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007076 ] ) ] . obo:GO_1903429 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell maturation." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-09-15T13:31:23Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of functional differentiation" ; oboInOwl:id "GO:1903429" ; a owl:Class ; rdfs:label "regulation of cell maturation" ; rdfs:subClassOf obo:GO_0060284, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048469 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048469 ] ) ] . obo:GO_1903430 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-09-15T13:31:32Z" ; oboInOwl:hasExactSynonym "down regulation of cell maturation", "down-regulation of cell maturation", "downregulation of cell maturation" ; oboInOwl:hasNarrowSynonym "inhibition of cell maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of functional differentiation", "down-regulation of functional differentiation", "downregulation of functional differentiation", "inhibition of functional differentiation", "negative regulation of functional differentiation" ; oboInOwl:id "GO:1903430" ; a owl:Class ; rdfs:label "negative regulation of cell maturation" ; rdfs:subClassOf obo:GO_0010721, obo:GO_1903429, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048469 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048469 ] ) ] . obo:GO_1903431 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell maturation." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-09-15T13:31:41Z" ; oboInOwl:hasExactSynonym "up regulation of cell maturation", "up-regulation of cell maturation", "upregulation of cell maturation" ; oboInOwl:hasNarrowSynonym "activation of cell maturation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of functional differentiation", "positive regulation of functional differentiation", "up regulation of functional differentiation", "up-regulation of functional differentiation", "upregulation of functional differentiation" ; oboInOwl:id "GO:1903431" ; a owl:Class ; rdfs:label "positive regulation of cell maturation" ; rdfs:subClassOf obo:GO_0010720, obo:GO_1903429, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048469 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048469 ] ) ] . obo:GO_1903487 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lactation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-09-24T14:44:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903487" ; a owl:Class ; rdfs:label "regulation of lactation" ; rdfs:subClassOf obo:GO_0050878, obo:GO_0051046, obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007595 ] ) ] . obo:GO_1903488 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-09-24T14:44:22Z" ; oboInOwl:hasExactSynonym "down regulation of lactation", "down-regulation of lactation", "downregulation of lactation" ; oboInOwl:hasNarrowSynonym "inhibition of lactation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903488" ; a owl:Class ; rdfs:label "negative regulation of lactation" ; rdfs:subClassOf obo:GO_0051048, obo:GO_0051093, obo:GO_0051241, obo:GO_1903487, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007595 ] ) ] . obo:GO_1903489 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lactation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-09-24T14:44:30Z" ; oboInOwl:hasExactSynonym "up regulation of lactation", "up-regulation of lactation", "upregulation of lactation" ; oboInOwl:hasNarrowSynonym "activation of lactation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903489" ; a owl:Class ; rdfs:label "positive regulation of lactation" ; rdfs:subClassOf obo:GO_0051047, obo:GO_0051094, obo:GO_0051240, obo:GO_1903487, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007595 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007595 ] ) ] . obo:GO_1903509 obo:IAO_0000115 "The chemical reactions and pathways involving liposaccharide." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2014-10-01T21:52:52Z" ; oboInOwl:hasExactSynonym "liposaccharide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903509" ; a owl:Class ; rdfs:label "liposaccharide metabolic process" ; rdfs:subClassOf obo:GO_0006629, obo:GO_1901135 . obo:GO_1903510 obo:IAO_0000115 "The chemical reactions and pathways involving mucopolysaccharide." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2014-10-01T21:55:47Z" ; oboInOwl:hasExactSynonym "mucopolysaccharide metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903510" ; a owl:Class ; rdfs:label "mucopolysaccharide metabolic process" ; rdfs:subClassOf obo:GO_0030203 . obo:GO_1903522 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood circulation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-10-06T18:38:56Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of hemolymph circulation" ; oboInOwl:id "GO:1903522" ; a owl:Class ; rdfs:label "regulation of blood circulation" ; rdfs:subClassOf obo:GO_0044057, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:GO_1903523 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-10-06T18:39:05Z" ; oboInOwl:hasExactSynonym "down regulation of blood circulation", "down-regulation of blood circulation", "downregulation of blood circulation" ; oboInOwl:hasNarrowSynonym "inhibition of blood circulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of hemolymph circulation", "down-regulation of hemolymph circulation", "downregulation of hemolymph circulation", "inhibition of hemolymph circulation", "negative regulation of hemolymph circulation" ; oboInOwl:id "GO:1903523" ; a owl:Class ; rdfs:label "negative regulation of blood circulation" ; rdfs:subClassOf obo:GO_0051241, obo:GO_1903522, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:GO_1903524 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood circulation." ; oboInOwl:created_by "mr" ; oboInOwl:creation_date "2014-10-06T18:39:13Z" ; oboInOwl:hasExactSynonym "up regulation of blood circulation", "up-regulation of blood circulation", "upregulation of blood circulation" ; oboInOwl:hasNarrowSynonym "activation of blood circulation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of hemolymph circulation", "positive regulation of hemolymph circulation", "up regulation of hemolymph circulation", "up-regulation of hemolymph circulation", "upregulation of hemolymph circulation" ; oboInOwl:id "GO:1903524" ; a owl:Class ; rdfs:label "positive regulation of blood circulation" ; rdfs:subClassOf obo:GO_0051240, obo:GO_1903522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:GO_1903530 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of secretion by cell." ; oboInOwl:created_by "pm" ; oboInOwl:creation_date "2014-10-08T13:24:59Z" ; oboInOwl:hasExactSynonym "regulation of cellular secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903530" ; a owl:Class ; rdfs:label "regulation of secretion by cell" ; rdfs:subClassOf obo:GO_0050794, obo:GO_0051046, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032940 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:GO_1903531 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." ; oboInOwl:created_by "pm" ; oboInOwl:creation_date "2014-10-08T13:25:08Z" ; oboInOwl:hasExactSynonym "down regulation of cellular secretion", "down regulation of secretion by cell", "down-regulation of cellular secretion", "down-regulation of secretion by cell", "downregulation of cellular secretion", "downregulation of secretion by cell", "negative regulation of cellular secretion" ; oboInOwl:hasNarrowSynonym "inhibition of cellular secretion", "inhibition of secretion by cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903531" ; a owl:Class ; rdfs:label "negative regulation of secretion by cell" ; rdfs:subClassOf obo:GO_0048523, obo:GO_0051048, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032940 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:GO_1903532 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of secretion by cell." ; oboInOwl:created_by "pm" ; oboInOwl:creation_date "2014-10-08T13:25:17Z" ; oboInOwl:hasExactSynonym "positive regulation of cellular secretion", "up regulation of cellular secretion", "up regulation of secretion by cell", "up-regulation of cellular secretion", "up-regulation of secretion by cell", "upregulation of cellular secretion", "upregulation of secretion by cell" ; oboInOwl:hasNarrowSynonym "activation of cellular secretion", "activation of secretion by cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903532" ; a owl:Class ; rdfs:label "positive regulation of secretion by cell" ; rdfs:subClassOf obo:GO_0048522, obo:GO_0051047, obo:GO_1903530, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032940 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032940 ] ) ] . obo:GO_1903551 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." ; oboInOwl:created_by "pga" ; oboInOwl:creation_date "2014-10-20T15:37:25Z" ; oboInOwl:hasExactSynonym "regulation of extracellular vesicular exosome assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903551" ; a owl:Class ; rdfs:label "regulation of extracellular exosome assembly" ; rdfs:subClassOf obo:GO_1902115, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071971 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071971 ] ) ] . obo:GO_1903552 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." ; oboInOwl:created_by "pga" ; oboInOwl:creation_date "2014-10-20T15:37:33Z" ; oboInOwl:hasExactSynonym "down regulation of extracellular vesicular exosome assembly", "down-regulation of extracellular vesicular exosome assembly", "downregulation of extracellular vesicular exosome assembly", "negative regulation of extracellular vesicular exosome assembly" ; oboInOwl:hasNarrowSynonym "inhibition of extracellular vesicular exosome assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903552" ; a owl:Class ; rdfs:label "negative regulation of extracellular exosome assembly" ; rdfs:subClassOf obo:GO_1902116, obo:GO_1903551, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071971 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071971 ] ) ] . obo:GO_1903553 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." ; oboInOwl:created_by "pga" ; oboInOwl:creation_date "2014-10-20T15:37:42Z" ; oboInOwl:hasExactSynonym "up regulation of extracellular vesicular exosome assembly", "up-regulation of extracellular vesicular exosome assembly", "upregulation of extracellular vesicular exosome assembly" ; oboInOwl:hasNarrowSynonym "activation of extracellular vesicular exosome assembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of extracellular vesicular exosome assembly" ; oboInOwl:id "GO:1903553" ; a owl:Class ; rdfs:label "positive regulation of extracellular exosome assembly" ; rdfs:subClassOf obo:GO_1902117, obo:GO_1903551, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071971 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071971 ] ) ] . obo:GO_1903561 obo:IAO_0000115 "Any vesicle that is part of the extracellular region." ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2014-10-22T14:26:11Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:hasRelatedSynonym "microparticle" ; oboInOwl:id "GO:1903561" ; a owl:Class ; rdfs:label "extracellular vesicle" ; rdfs:subClassOf obo:GO_0031982, obo:GO_0065010 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0031982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005576 ] ) ] . obo:GO_1903564 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein localization to cilium." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2014-10-24T20:58:11Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903564" ; a owl:Class ; rdfs:label "regulation of protein localization to cilium" ; rdfs:subClassOf obo:GO_0032880, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0061512 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0061512 ] ) ] . obo:GO_1903565 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2014-10-24T20:58:20Z" ; oboInOwl:hasExactSynonym "down regulation of protein localization to cilium", "down-regulation of protein localization to cilium", "downregulation of protein localization to cilium" ; oboInOwl:hasNarrowSynonym "inhibition of protein localization to cilium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903565" ; a owl:Class ; rdfs:label "negative regulation of protein localization to cilium" ; rdfs:subClassOf obo:GO_1903564, obo:GO_1903828, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0061512 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0061512 ] ) ] . obo:GO_1903566 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2014-10-24T20:58:28Z" ; oboInOwl:hasExactSynonym "up regulation of protein localization to cilium", "up-regulation of protein localization to cilium", "upregulation of protein localization to cilium" ; oboInOwl:hasNarrowSynonym "activation of protein localization to cilium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903566" ; a owl:Class ; rdfs:label "positive regulation of protein localization to cilium" ; rdfs:subClassOf obo:GO_1903564, obo:GO_1903829, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0061512 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0061512 ] ) ] . obo:GO_1903706 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of hemopoiesis." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-12-04T15:34:13Z" ; oboInOwl:hasExactSynonym "regulation of blood cell biosynthesis", "regulation of blood cell formation", "regulation of haemopoiesis", "regulation of hematopoiesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903706" ; a owl:Class ; rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ; rdfs:label "regulation of hemopoiesis" ; rdfs:subClassOf obo:GO_0002682, obo:GO_0060284, obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030097 ] ) ] . obo:GO_1903707 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-12-04T15:34:21Z" ; oboInOwl:hasExactSynonym "down regulation of blood cell biosynthesis", "down regulation of blood cell formation", "down regulation of haemopoiesis", "down regulation of hematopoiesis", "down regulation of hemopoiesis", "down-regulation of blood cell biosynthesis", "down-regulation of blood cell formation", "down-regulation of haemopoiesis", "down-regulation of hematopoiesis", "down-regulation of hemopoiesis", "downregulation of blood cell biosynthesis", "downregulation of blood cell formation", "downregulation of haemopoiesis", "downregulation of hematopoiesis", "downregulation of hemopoiesis", "negative regulation of blood cell biosynthesis", "negative regulation of blood cell formation", "negative regulation of haemopoiesis", "negative regulation of hematopoiesis" ; oboInOwl:hasNarrowSynonym "inhibition of blood cell biosynthesis", "inhibition of blood cell formation", "inhibition of haemopoiesis", "inhibition of hematopoiesis", "inhibition of hemopoiesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903707" ; a owl:Class ; rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ; rdfs:label "negative regulation of hemopoiesis" ; rdfs:subClassOf obo:GO_0002683, obo:GO_0010721, obo:GO_0051241, obo:GO_1903706, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030097 ] ) ] . obo:GO_1903708 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of hemopoiesis." ; oboInOwl:created_by "pad" ; oboInOwl:creation_date "2014-12-04T15:34:30Z" ; oboInOwl:hasExactSynonym "positive regulation of blood cell biosynthesis", "positive regulation of blood cell formation", "positive regulation of haemopoiesis", "positive regulation of hematopoiesis", "up regulation of blood cell biosynthesis", "up regulation of blood cell formation", "up regulation of haemopoiesis", "up regulation of hematopoiesis", "up regulation of hemopoiesis", "up-regulation of blood cell biosynthesis", "up-regulation of blood cell formation", "up-regulation of haemopoiesis", "up-regulation of hematopoiesis", "up-regulation of hemopoiesis", "upregulation of blood cell biosynthesis", "upregulation of blood cell formation", "upregulation of haemopoiesis", "upregulation of hematopoiesis", "upregulation of hemopoiesis" ; oboInOwl:hasNarrowSynonym "activation of blood cell biosynthesis", "activation of blood cell formation", "activation of haemopoiesis", "activation of hematopoiesis", "activation of hemopoiesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903708" ; a owl:Class ; rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ; rdfs:label "positive regulation of hemopoiesis" ; rdfs:subClassOf obo:GO_0002684, obo:GO_0010720, obo:GO_0051240, obo:GO_1903706, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030097 ] ) ] . obo:GO_1903729 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of plasma membrane organization." ; oboInOwl:created_by "al" ; oboInOwl:creation_date "2014-12-10T18:59:44Z" ; oboInOwl:hasExactSynonym "regulation of plasma membrane organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of plasma membrane organization and biogenesis" ; oboInOwl:id "GO:1903729" ; a owl:Class ; rdfs:label "regulation of plasma membrane organization" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007009 ] ) ] . obo:GO_1903770 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." ; oboInOwl:created_by "nc" ; oboInOwl:creation_date "2015-01-06T10:53:22Z" ; oboInOwl:hasExactSynonym "down regulation of beta-D-galactanase activity", "down regulation of beta-D-galactoside galactohydrolase activity", "down regulation of beta-D-lactosidase activity", "down regulation of beta-galactosidase activity", "down regulation of beta-lactosidase activity", "down regulation of exo-(1->4)-beta-D-galactanase activity", "down regulation of trilactase activity", "down-regulation of beta-D-galactanase activity", "down-regulation of beta-D-galactoside galactohydrolase activity", "down-regulation of beta-D-lactosidase activity", "down-regulation of beta-galactosidase activity", "down-regulation of beta-lactosidase activity", "down-regulation of exo-(1->4)-beta-D-galactanase activity", "down-regulation of trilactase activity", "downregulation of beta-D-galactanase activity", "downregulation of beta-D-galactoside galactohydrolase activity", "downregulation of beta-D-lactosidase activity", "downregulation of beta-galactosidase activity", "downregulation of beta-lactosidase activity", "downregulation of exo-(1->4)-beta-D-galactanase activity", "downregulation of trilactase activity", "negative regulation of beta-D-galactanase activity", "negative regulation of beta-D-galactoside galactohydrolase activity", "negative regulation of beta-D-lactosidase activity", "negative regulation of beta-lactosidase activity", "negative regulation of exo-(1->4)-beta-D-galactanase activity", "negative regulation of trilactase activity" ; oboInOwl:hasNarrowSynonym "inhibition of beta-D-galactanase activity", "inhibition of beta-D-galactoside galactohydrolase activity", "inhibition of beta-D-lactosidase activity", "inhibition of beta-galactosidase activity", "inhibition of beta-lactosidase activity", "inhibition of exo-(1->4)-beta-D-galactanase activity", "inhibition of trilactase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of S 2107", "down regulation of hydrolact", "down regulation of lactose hydrolysis", "down regulation of lactozym", "down regulation of maxilact", "down regulation of oryzatym", "down regulation of sumiklat", "down-regulation of S 2107", "down-regulation of hydrolact", "down-regulation of lactose hydrolysis", "down-regulation of lactozym", "down-regulation of maxilact", "down-regulation of oryzatym", "down-regulation of sumiklat", "downregulation of S 2107", "downregulation of hydrolact", "downregulation of lactose hydrolysis", "downregulation of lactozym", "downregulation of maxilact", "downregulation of oryzatym", "downregulation of sumiklat", "inhibition of S 2107", "inhibition of hydrolact", "inhibition of lactose hydrolysis", "inhibition of lactozym", "inhibition of maxilact", "inhibition of oryzatym", "inhibition of sumiklat", "negative regulation of S 2107", "negative regulation of hydrolact", "negative regulation of lactose hydrolysis", "negative regulation of lactozym", "negative regulation of maxilact", "negative regulation of oryzatym", "negative regulation of sumiklat" ; oboInOwl:id "GO:1903770" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of beta-galactosidase activity" ; rdfs:subClassOf obo:GO_0051346, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0004565 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0004565 ] ) ] . obo:GO_1903771 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity." ; oboInOwl:created_by "nc" ; oboInOwl:creation_date "2015-01-06T10:53:32Z" ; oboInOwl:hasExactSynonym "positive regulation of beta-D-galactanase activity", "positive regulation of beta-D-galactoside galactohydrolase activity", "positive regulation of beta-D-lactosidase activity", "positive regulation of beta-lactosidase activity", "positive regulation of exo-(1->4)-beta-D-galactanase activity", "positive regulation of trilactase activity", "up regulation of beta-D-galactanase activity", "up regulation of beta-D-galactoside galactohydrolase activity", "up regulation of beta-D-lactosidase activity", "up regulation of beta-galactosidase activity", "up regulation of beta-lactosidase activity", "up regulation of exo-(1->4)-beta-D-galactanase activity", "up regulation of trilactase activity", "up-regulation of beta-D-galactanase activity", "up-regulation of beta-D-galactoside galactohydrolase activity", "up-regulation of beta-D-lactosidase activity", "up-regulation of beta-galactosidase activity", "up-regulation of beta-lactosidase activity", "up-regulation of exo-(1->4)-beta-D-galactanase activity", "up-regulation of trilactase activity", "upregulation of beta-D-galactanase activity", "upregulation of beta-D-galactoside galactohydrolase activity", "upregulation of beta-D-lactosidase activity", "upregulation of beta-galactosidase activity", "upregulation of beta-lactosidase activity", "upregulation of exo-(1->4)-beta-D-galactanase activity", "upregulation of trilactase activity" ; oboInOwl:hasNarrowSynonym "activation of beta-D-galactanase activity", "activation of beta-D-galactoside galactohydrolase activity", "activation of beta-D-lactosidase activity", "activation of beta-galactosidase activity", "activation of beta-lactosidase activity", "activation of exo-(1->4)-beta-D-galactanase activity", "activation of trilactase activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of S 2107", "activation of hydrolact", "activation of lactose hydrolysis", "activation of lactozym", "activation of maxilact", "activation of oryzatym", "activation of sumiklat", "positive regulation of S 2107", "positive regulation of hydrolact", "positive regulation of lactose hydrolysis", "positive regulation of lactozym", "positive regulation of maxilact", "positive regulation of oryzatym", "positive regulation of sumiklat", "up regulation of S 2107", "up regulation of hydrolact", "up regulation of lactose hydrolysis", "up regulation of lactozym", "up regulation of maxilact", "up regulation of oryzatym", "up regulation of sumiklat", "up-regulation of S 2107", "up-regulation of hydrolact", "up-regulation of lactose hydrolysis", "up-regulation of lactozym", "up-regulation of maxilact", "up-regulation of oryzatym", "up-regulation of sumiklat", "upregulation of S 2107", "upregulation of hydrolact", "upregulation of lactose hydrolysis", "upregulation of lactozym", "upregulation of maxilact", "upregulation of oryzatym", "upregulation of sumiklat" ; oboInOwl:id "GO:1903771" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of beta-galactosidase activity" ; rdfs:subClassOf obo:GO_0051345, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0004565 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0004565 ] ) ] . obo:GO_1903828 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2015-01-20T14:32:24Z" ; oboInOwl:hasExactSynonym "down regulation of cellular protein localisation", "down regulation of cellular protein localization", "down-regulation of cellular protein localisation", "down-regulation of cellular protein localization", "downregulation of cellular protein localisation", "downregulation of cellular protein localization", "negative regulation of cellular protein localisation", "negative regulation of cellular protein localization" ; oboInOwl:hasNarrowSynonym "inhibition of cellular protein localisation", "inhibition of cellular protein localization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903828" ; a owl:Class ; rdfs:label "negative regulation of protein localization" ; rdfs:subClassOf obo:GO_0032880, obo:GO_0048523, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008104 ] ) ] . obo:GO_1903829 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of a protein localization." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI ; oboInOwl:created_by "jl" ; oboInOwl:creation_date "2015-01-20T14:32:33Z" ; oboInOwl:hasExactSynonym "positive regulation of cellular protein localisation", "positive regulation of cellular protein localization", "up regulation of cellular protein localisation", "up regulation of cellular protein localization", "up-regulation of cellular protein localisation", "up-regulation of cellular protein localization", "upregulation of cellular protein localisation", "upregulation of cellular protein localization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903829" ; a owl:Class ; rdfs:label "positive regulation of protein localization" ; rdfs:subClassOf obo:GO_0032880, obo:GO_0048522, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008104 ] ) ] . obo:GO_1903941 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-02-17T20:26:24Z" ; oboInOwl:hasExactSynonym "down regulation of respiratory gaseous exchange", "down-regulation of respiratory gaseous exchange", "downregulation of respiratory gaseous exchange" ; oboInOwl:hasNarrowSynonym "inhibition of respiratory gaseous exchange" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903941" ; a owl:Class ; rdfs:label "negative regulation of respiratory gaseous exchange" ; rdfs:subClassOf obo:GO_0043576, obo:GO_0051241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007585 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:GO_1903942 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-02-17T20:26:35Z" ; oboInOwl:hasExactSynonym "up regulation of respiratory gaseous exchange", "up-regulation of respiratory gaseous exchange", "upregulation of respiratory gaseous exchange" ; oboInOwl:hasNarrowSynonym "activation of respiratory gaseous exchange" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903942" ; a owl:Class ; rdfs:label "positive regulation of respiratory gaseous exchange" ; rdfs:subClassOf obo:GO_0043576, obo:GO_0051240, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007585 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:GO_1903998 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of eating behavior." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-05T20:40:22Z" ; oboInOwl:hasExactSynonym "regulation of eating behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903998" ; a owl:Class ; rdfs:label "regulation of eating behavior" ; rdfs:subClassOf obo:GO_0060259, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042755 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0042755 ] ) ] . obo:GO_1903999 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-05T20:40:28Z" ; oboInOwl:hasExactSynonym "down regulation of eating behavior", "down regulation of eating behaviour", "down-regulation of eating behavior", "down-regulation of eating behaviour", "downregulation of eating behavior", "downregulation of eating behaviour", "negative regulation of eating behaviour" ; oboInOwl:hasNarrowSynonym "inhibition of eating behavior", "inhibition of eating behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1903999" ; a owl:Class ; rdfs:label "negative regulation of eating behavior" ; rdfs:subClassOf obo:GO_1903998, obo:GO_2000252, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042755 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0042755 ] ) ] . obo:GO_1904000 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of eating behavior." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-05T20:40:35Z" ; oboInOwl:hasExactSynonym "positive regulation of eating behaviour", "up regulation of eating behavior", "up regulation of eating behaviour", "up-regulation of eating behavior", "up-regulation of eating behaviour", "upregulation of eating behavior", "upregulation of eating behaviour" ; oboInOwl:hasNarrowSynonym "activation of eating behavior", "activation of eating behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904000" ; a owl:Class ; rdfs:label "positive regulation of eating behavior" ; rdfs:subClassOf obo:GO_1903998, obo:GO_2000253, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042755 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0042755 ] ) ] . obo:GO_1904018 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of vasculature development." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-06T22:17:04Z" ; oboInOwl:hasExactSynonym "up regulation of vasculature development", "up-regulation of vasculature development", "upregulation of vasculature development" ; oboInOwl:hasNarrowSynonym "activation of vasculature development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of vascular system development", "positive regulation of vascular system development", "up regulation of vascular system development", "up-regulation of vascular system development", "upregulation of vascular system development" ; oboInOwl:id "GO:1904018" ; a owl:Class ; rdfs:label "positive regulation of vasculature development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_0051240, obo:GO_1901342, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001944 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001944 ] ) ] . obo:GO_1904057 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-18T20:33:57Z" ; oboInOwl:hasExactSynonym "down regulation of nociception", "down regulation of sensory perception of pain", "down-regulation of nociception", "down-regulation of sensory perception of pain", "downregulation of nociception", "downregulation of sensory perception of pain", "negative regulation of nociception" ; oboInOwl:hasNarrowSynonym "down regulation of perception of physiological pain", "down-regulation of perception of physiological pain", "downregulation of perception of physiological pain", "inhibition of nociception", "inhibition of perception of physiological pain", "inhibition of sensory perception of pain", "negative regulation of perception of physiological pain" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904057" ; a owl:Class ; rdfs:label "negative regulation of sensory perception of pain" ; rdfs:subClassOf obo:GO_0031645, obo:GO_0051930, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019233 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_1904058 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-03-18T20:34:03Z" ; oboInOwl:hasExactSynonym "positive regulation of nociception", "up regulation of nociception", "up regulation of sensory perception of pain", "up-regulation of nociception", "up-regulation of sensory perception of pain", "upregulation of nociception", "upregulation of sensory perception of pain" ; oboInOwl:hasNarrowSynonym "activation of nociception", "activation of perception of physiological pain", "activation of sensory perception of pain", "positive regulation of perception of physiological pain", "up regulation of perception of physiological pain", "up-regulation of perception of physiological pain", "upregulation of perception of physiological pain" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904058" ; a owl:Class ; rdfs:label "positive regulation of sensory perception of pain" ; rdfs:subClassOf obo:GO_0031646, obo:GO_0051930, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019233 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0019233 ] ) ] . obo:GO_1904068 obo:IAO_0000115 "Any G protein-coupled receptor signaling pathway that is involved in social behavior." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2015-03-20T01:51:10Z" ; oboInOwl:hasExactSynonym "G protein coupled receptor protein signaling pathway involved in social behavior", "G protein coupled receptor protein signaling pathway involved in social behaviour", "G protein coupled receptor protein signalling pathway involved in social behavior", "G protein coupled receptor protein signalling pathway involved in social behaviour", "G-protein coupled receptor protein signal transduction involved in social behavior", "G-protein coupled receptor protein signal transduction involved in social behaviour", "G-protein coupled receptor protein signaling pathway involved in social behavior", "G-protein coupled receptor protein signaling pathway involved in social behaviour", "G-protein coupled receptor signaling pathway involved in social behavior", "G-protein coupled receptor signaling pathway involved in social behaviour", "G-protein coupled receptor signalling pathway involved in social behavior", "G-protein coupled receptor signalling pathway involved in social behaviour", "G-protein-coupled receptor protein signaling pathway involved in social behavior", "G-protein-coupled receptor protein signaling pathway involved in social behaviour", "G-protein-coupled receptor protein signalling pathway involved in social behavior", "G-protein-coupled receptor protein signalling pathway involved in social behaviour", "GPCR signaling pathway involved in social behavior", "GPCR signaling pathway involved in social behaviour", "GPCR signalling pathway involved in social behavior", "GPCR signalling pathway involved in social behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "G protein coupled receptor protein signaling pathway involved in cooperative behavior", "G protein coupled receptor protein signalling pathway involved in cooperative behavior", "G-protein coupled receptor protein signal transduction involved in cooperative behavior", "G-protein coupled receptor protein signaling pathway involved in cooperative behavior", "G-protein coupled receptor signaling pathway involved in cooperative behavior", "G-protein coupled receptor signalling pathway involved in cooperative behavior", "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior", "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior", "GPCR signaling pathway involved in cooperative behavior", "GPCR signalling pathway involved in cooperative behavior" ; oboInOwl:id "GO:1904068" ; a owl:Class ; rdfs:label "G protein-coupled receptor signaling pathway involved in social behavior" ; rdfs:subClassOf obo:GO_0007186, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0035176 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0035176 ] ) ] . obo:GO_1904098 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2015-03-27T16:09:58Z" ; oboInOwl:hasExactSynonym "regulation of protein amino acid O-linked glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904098" ; a owl:Class ; rdfs:label "regulation of protein O-linked glycosylation" ; rdfs:subClassOf obo:GO_0060049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006493 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006493 ] ) ] . obo:GO_1904099 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2015-03-27T16:10:04Z" ; oboInOwl:hasExactSynonym "down regulation of protein O-linked glycosylation", "down regulation of protein amino acid O-linked glycosylation", "down-regulation of protein O-linked glycosylation", "down-regulation of protein amino acid O-linked glycosylation", "downregulation of protein O-linked glycosylation", "downregulation of protein amino acid O-linked glycosylation", "negative regulation of protein amino acid O-linked glycosylation" ; oboInOwl:hasNarrowSynonym "inhibition of protein O-linked glycosylation", "inhibition of protein amino acid O-linked glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904099" ; a owl:Class ; rdfs:label "negative regulation of protein O-linked glycosylation" ; rdfs:subClassOf obo:GO_0060051, obo:GO_1904098, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006493 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006493 ] ) ] . obo:GO_1904100 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2015-03-27T16:10:10Z" ; oboInOwl:hasExactSynonym "positive regulation of protein amino acid O-linked glycosylation", "up regulation of protein O-linked glycosylation", "up regulation of protein amino acid O-linked glycosylation", "up-regulation of protein O-linked glycosylation", "up-regulation of protein amino acid O-linked glycosylation", "upregulation of protein O-linked glycosylation", "upregulation of protein amino acid O-linked glycosylation" ; oboInOwl:hasNarrowSynonym "activation of protein O-linked glycosylation", "activation of protein amino acid O-linked glycosylation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904100" ; a owl:Class ; rdfs:label "positive regulation of protein O-linked glycosylation" ; rdfs:subClassOf obo:GO_0060050, obo:GO_1904098, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006493 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006493 ] ) ] . obo:GO_1904115 obo:IAO_0000115 "Any cytoplasm that is part of a axon." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/14472"^^xsd:anyURI ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-04-06T18:13:14Z" ; oboInOwl:hasExactSynonym "axoplasm" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:1904115" ; a owl:Class ; rdfs:label "axon cytoplasm" ; rdfs:subClassOf obo:GO_0120111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030424 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0005737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030424 ] ) ] . obo:GO_1904170 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bleb assembly." ; oboInOwl:created_by "als" ; oboInOwl:creation_date "2015-04-23T09:32:19Z" ; oboInOwl:hasExactSynonym "regulation of cell blebbing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904170" ; a owl:Class ; rdfs:label "regulation of bleb assembly" ; rdfs:subClassOf obo:GO_0120032, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0032060 ] ) ] . obo:GO_1904171 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." ; oboInOwl:created_by "als" ; oboInOwl:creation_date "2015-04-23T09:32:25Z" ; oboInOwl:hasExactSynonym "down regulation of bleb assembly", "down regulation of cell blebbing", "down-regulation of bleb assembly", "down-regulation of cell blebbing", "downregulation of bleb assembly", "downregulation of cell blebbing", "negative regulation of cell blebbing" ; oboInOwl:hasNarrowSynonym "inhibition of bleb assembly", "inhibition of cell blebbing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904171" ; a owl:Class ; rdfs:label "negative regulation of bleb assembly" ; rdfs:subClassOf obo:GO_0120033, obo:GO_1904170, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0032060 ] ) ] . obo:GO_1904172 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bleb assembly." ; oboInOwl:created_by "als" ; oboInOwl:creation_date "2015-04-23T09:32:31Z" ; oboInOwl:hasExactSynonym "positive regulation of cell blebbing", "up regulation of bleb assembly", "up regulation of cell blebbing", "up-regulation of bleb assembly", "up-regulation of cell blebbing", "upregulation of bleb assembly", "upregulation of cell blebbing" ; oboInOwl:hasNarrowSynonym "activation of bleb assembly", "activation of cell blebbing" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904172" ; a owl:Class ; rdfs:label "positive regulation of bleb assembly" ; rdfs:subClassOf obo:GO_0120034, obo:GO_1904170, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032060 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0032060 ] ) ] . obo:GO_1904251 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of bile acid metabolic process." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2015-05-20T11:04:28Z" ; oboInOwl:hasExactSynonym "regulation of bile acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904251" ; a owl:Class ; rdfs:label "regulation of bile acid metabolic process" ; rdfs:subClassOf obo:GO_0019218, obo:GO_0031323, obo:GO_0062012, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0008206 ] ) ] . obo:GO_1904252 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2015-05-20T11:04:35Z" ; oboInOwl:hasExactSynonym "down regulation of bile acid metabolic process", "down regulation of bile acid metabolism", "down-regulation of bile acid metabolic process", "down-regulation of bile acid metabolism", "downregulation of bile acid metabolic process", "downregulation of bile acid metabolism", "negative regulation of bile acid metabolism" ; oboInOwl:hasNarrowSynonym "inhibition of bile acid metabolic process", "inhibition of bile acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904252" ; a owl:Class ; rdfs:label "negative regulation of bile acid metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0045939, obo:GO_0062014, obo:GO_1904251, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0008206 ] ) ] . obo:GO_1904253 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2015-05-20T11:04:40Z" ; oboInOwl:hasExactSynonym "positive regulation of bile acid metabolism", "up regulation of bile acid metabolic process", "up regulation of bile acid metabolism", "up-regulation of bile acid metabolic process", "up-regulation of bile acid metabolism", "upregulation of bile acid metabolic process", "upregulation of bile acid metabolism" ; oboInOwl:hasNarrowSynonym "activation of bile acid metabolic process", "activation of bile acid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904253" ; a owl:Class ; rdfs:label "positive regulation of bile acid metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0045940, obo:GO_0062013, obo:GO_1904251, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008206 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0008206 ] ) ] . obo:GO_1904304 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-09T23:18:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904304" ; a owl:Class ; rdfs:label "regulation of gastro-intestinal system smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006940, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0014831 ] ) ] . obo:GO_1904305 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-09T23:18:48Z" ; oboInOwl:hasExactSynonym "down regulation of gastro-intestinal system smooth muscle contraction", "down-regulation of gastro-intestinal system smooth muscle contraction", "downregulation of gastro-intestinal system smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "inhibition of gastro-intestinal system smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904305" ; a owl:Class ; rdfs:label "negative regulation of gastro-intestinal system smooth muscle contraction" ; rdfs:subClassOf obo:GO_0045986, obo:GO_1904304, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0014831 ] ) ] . obo:GO_1904306 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-09T23:18:54Z" ; oboInOwl:hasExactSynonym "up regulation of gastro-intestinal system smooth muscle contraction", "up-regulation of gastro-intestinal system smooth muscle contraction", "upregulation of gastro-intestinal system smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "activation of gastro-intestinal system smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904306" ; a owl:Class ; rdfs:label "positive regulation of gastro-intestinal system smooth muscle contraction" ; rdfs:subClassOf obo:GO_0045987, obo:GO_1904304, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0014831 ] ) ] . obo:GO_1904318 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-10T18:46:11Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of smooth muscle contraction involved in urination", "regulation of urinary bladder smooth muscle contraction involved in micturition" ; oboInOwl:id "GO:1904318" ; a owl:Class ; rdfs:label "regulation of smooth muscle contraction involved in micturition" ; rdfs:subClassOf obo:GO_0006940, obo:GO_0044062, obo:GO_0098801, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060083 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060083 ] ) ] . obo:GO_1904319 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-10T18:46:17Z" ; oboInOwl:hasExactSynonym "down regulation of smooth muscle contraction involved in micturition", "down-regulation of smooth muscle contraction involved in micturition", "downregulation of smooth muscle contraction involved in micturition" ; oboInOwl:hasNarrowSynonym "inhibition of smooth muscle contraction involved in micturition" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of smooth muscle contraction involved in urination", "down regulation of urinary bladder smooth muscle contraction involved in micturition", "down-regulation of smooth muscle contraction involved in urination", "down-regulation of urinary bladder smooth muscle contraction involved in micturition", "downregulation of smooth muscle contraction involved in urination", "downregulation of urinary bladder smooth muscle contraction involved in micturition", "inhibition of smooth muscle contraction involved in urination", "inhibition of urinary bladder smooth muscle contraction involved in micturition", "negative regulation of smooth muscle contraction involved in urination", "negative regulation of urinary bladder smooth muscle contraction involved in micturition" ; oboInOwl:id "GO:1904319" ; a owl:Class ; rdfs:label "negative regulation of smooth muscle contraction involved in micturition" ; rdfs:subClassOf obo:GO_0045986, obo:GO_1904318, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060083 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060083 ] ) ] . obo:GO_1904320 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-10T18:46:23Z" ; oboInOwl:hasExactSynonym "up regulation of smooth muscle contraction involved in micturition", "up-regulation of smooth muscle contraction involved in micturition", "upregulation of smooth muscle contraction involved in micturition" ; oboInOwl:hasNarrowSynonym "activation of smooth muscle contraction involved in micturition" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of smooth muscle contraction involved in urination", "activation of urinary bladder smooth muscle contraction involved in micturition", "positive regulation of smooth muscle contraction involved in urination", "positive regulation of urinary bladder smooth muscle contraction involved in micturition", "up regulation of smooth muscle contraction involved in urination", "up regulation of urinary bladder smooth muscle contraction involved in micturition", "up-regulation of smooth muscle contraction involved in urination", "up-regulation of urinary bladder smooth muscle contraction involved in micturition", "upregulation of smooth muscle contraction involved in urination", "upregulation of urinary bladder smooth muscle contraction involved in micturition" ; oboInOwl:id "GO:1904320" ; a owl:Class ; rdfs:label "positive regulation of smooth muscle contraction involved in micturition" ; rdfs:subClassOf obo:GO_0045987, obo:GO_1904318, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060083 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060083 ] ) ] . obo:GO_1904347 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-11T21:37:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904347" ; a owl:Class ; rdfs:label "regulation of small intestine smooth muscle contraction" ; rdfs:subClassOf obo:GO_1904304, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1990770 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1990770 ] ) ] . obo:GO_1904348 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-11T21:37:40Z" ; oboInOwl:hasExactSynonym "down regulation of small intestine smooth muscle contraction", "down-regulation of small intestine smooth muscle contraction", "downregulation of small intestine smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "inhibition of small intestine smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904348" ; a owl:Class ; rdfs:label "negative regulation of small intestine smooth muscle contraction" ; rdfs:subClassOf obo:GO_1904305, obo:GO_1904347, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1990770 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1990770 ] ) ] . obo:GO_1904349 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-11T21:37:46Z" ; oboInOwl:hasExactSynonym "up regulation of small intestine smooth muscle contraction", "up-regulation of small intestine smooth muscle contraction", "upregulation of small intestine smooth muscle contraction" ; oboInOwl:hasNarrowSynonym "activation of small intestine smooth muscle contraction" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904349" ; a owl:Class ; rdfs:label "positive regulation of small intestine smooth muscle contraction" ; rdfs:subClassOf obo:GO_1904306, obo:GO_1904347, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1990770 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1990770 ] ) ] . obo:GO_1904362 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of calcitonin secretion." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-15T17:54:52Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904362" ; a owl:Class ; rdfs:label "regulation of calcitonin secretion" ; rdfs:subClassOf obo:GO_0090276, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0036161 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:GO_1904363 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-15T17:54:58Z" ; oboInOwl:hasExactSynonym "down regulation of calcitonin secretion", "down-regulation of calcitonin secretion", "downregulation of calcitonin secretion" ; oboInOwl:hasNarrowSynonym "inhibition of calcitonin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904363" ; a owl:Class ; rdfs:label "negative regulation of calcitonin secretion" ; rdfs:subClassOf obo:GO_0090278, obo:GO_1904362, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0036161 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:GO_1904364 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-15T17:55:05Z" ; oboInOwl:hasExactSynonym "up regulation of calcitonin secretion", "up-regulation of calcitonin secretion", "upregulation of calcitonin secretion" ; oboInOwl:hasNarrowSynonym "activation of calcitonin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904364" ; a owl:Class ; rdfs:label "positive regulation of calcitonin secretion" ; rdfs:subClassOf obo:GO_0090277, obo:GO_1904362, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0036161 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0036161 ] ) ] . obo:GO_1904409 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of secretory granule organization." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-25T19:40:42Z" ; oboInOwl:hasExactSynonym "regulation of secretory granule organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of secretory granule organization and biogenesis" ; oboInOwl:id "GO:1904409" ; a owl:Class ; rdfs:label "regulation of secretory granule organization" ; rdfs:subClassOf obo:GO_0033043, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033363 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0033363 ] ) ] . obo:GO_1904410 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-25T19:40:49Z" ; oboInOwl:hasExactSynonym "down regulation of secretory granule organisation", "down regulation of secretory granule organization", "down-regulation of secretory granule organisation", "down-regulation of secretory granule organization", "downregulation of secretory granule organisation", "downregulation of secretory granule organization", "negative regulation of secretory granule organisation" ; oboInOwl:hasNarrowSynonym "inhibition of secretory granule organisation", "inhibition of secretory granule organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of secretory granule organization and biogenesis", "down-regulation of secretory granule organization and biogenesis", "downregulation of secretory granule organization and biogenesis", "inhibition of secretory granule organization and biogenesis", "negative regulation of secretory granule organization and biogenesis" ; oboInOwl:id "GO:1904410" ; a owl:Class ; rdfs:label "negative regulation of secretory granule organization" ; rdfs:subClassOf obo:GO_0010639, obo:GO_1904409, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033363 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0033363 ] ) ] . obo:GO_1904411 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of secretory granule organization." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-25T19:40:55Z" ; oboInOwl:hasExactSynonym "positive regulation of secretory granule organisation", "up regulation of secretory granule organisation", "up regulation of secretory granule organization", "up-regulation of secretory granule organisation", "up-regulation of secretory granule organization", "upregulation of secretory granule organisation", "upregulation of secretory granule organization" ; oboInOwl:hasNarrowSynonym "activation of secretory granule organisation", "activation of secretory granule organization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of secretory granule organization and biogenesis", "positive regulation of secretory granule organization and biogenesis", "up regulation of secretory granule organization and biogenesis", "up-regulation of secretory granule organization and biogenesis", "upregulation of secretory granule organization and biogenesis" ; oboInOwl:id "GO:1904411" ; a owl:Class ; rdfs:label "positive regulation of secretory granule organization" ; rdfs:subClassOf obo:GO_0010638, obo:GO_1904409, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033363 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0033363 ] ) ] . obo:GO_1904478 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of intestinal absorption." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2015-07-13T15:58:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904478" ; a owl:Class ; rdfs:label "regulation of intestinal absorption" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0051049, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050892 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050892 ] ) ] . obo:GO_1904479 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2015-07-13T15:58:54Z" ; oboInOwl:hasExactSynonym "down regulation of intestinal absorption", "down-regulation of intestinal absorption", "downregulation of intestinal absorption" ; oboInOwl:hasNarrowSynonym "inhibition of intestinal absorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904479" ; a owl:Class ; rdfs:label "negative regulation of intestinal absorption" ; rdfs:subClassOf obo:GO_0051051, obo:GO_0060457, obo:GO_1904478, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050892 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050892 ] ) ] . obo:GO_1904480 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of intestinal absorption." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2015-07-13T15:59:00Z" ; oboInOwl:hasExactSynonym "up regulation of intestinal absorption", "up-regulation of intestinal absorption", "upregulation of intestinal absorption" ; oboInOwl:hasNarrowSynonym "activation of intestinal absorption" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904480" ; a owl:Class ; rdfs:label "positive regulation of intestinal absorption" ; rdfs:subClassOf obo:GO_0051050, obo:GO_0060456, obo:GO_1904478, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050892 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050892 ] ) ] . obo:GO_1904659 obo:IAO_0000115 "The process in which glucose is transported across a membrane." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2015-09-04T17:20:16Z" ; oboInOwl:hasAlternativeId "GO:0015758" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "glucose transport" ; oboInOwl:id "GO:1904659" ; a owl:Class ; rdfs:label "glucose transmembrane transport" ; rdfs:subClassOf obo:GO_0008645 . obo:GO_1904675 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of somatic stem cell division." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2015-09-14T08:47:22Z" ; oboInOwl:hasExactSynonym "regulation of somatic stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904675" ; a owl:Class ; rdfs:label "regulation of somatic stem cell division" ; rdfs:subClassOf obo:GO_2000035, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048103 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048103 ] ) ] . obo:GO_1904676 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2015-09-14T08:47:28Z" ; oboInOwl:hasExactSynonym "down regulation of somatic stem cell division", "down regulation of somatic stem cell renewal", "down-regulation of somatic stem cell division", "down-regulation of somatic stem cell renewal", "downregulation of somatic stem cell division", "downregulation of somatic stem cell renewal", "negative regulation of somatic stem cell renewal" ; oboInOwl:hasNarrowSynonym "inhibition of somatic stem cell division", "inhibition of somatic stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904676" ; a owl:Class ; rdfs:label "negative regulation of somatic stem cell division" ; rdfs:subClassOf obo:GO_0051782, obo:GO_1904675, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048103 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048103 ] ) ] . obo:GO_1904677 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2015-09-14T08:47:34Z" ; oboInOwl:hasExactSynonym "positive regulation of somatic stem cell renewal", "up regulation of somatic stem cell division", "up regulation of somatic stem cell renewal", "up-regulation of somatic stem cell division", "up-regulation of somatic stem cell renewal", "upregulation of somatic stem cell division", "upregulation of somatic stem cell renewal" ; oboInOwl:hasNarrowSynonym "activation of somatic stem cell division", "activation of somatic stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904677" ; a owl:Class ; rdfs:label "positive regulation of somatic stem cell division" ; rdfs:subClassOf obo:GO_0051781, obo:GO_1904675, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048103 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048103 ] ) ] . obo:GO_1904746 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." ; oboInOwl:created_by "es" ; oboInOwl:creation_date "2015-10-19T14:12:27Z" ; oboInOwl:hasExactSynonym "down regulation of apoptotic cell death involved in anatomical structure development", "down regulation of apoptotic cell death involved in development of an anatomical structure", "down regulation of apoptotic process involved in anatomical structure development", "down regulation of apoptotic process involved in development", "down regulation of apoptotic process involved in development of an anatomical structure", "down regulation of apoptotic programmed cell death involved in anatomical structure development", "down regulation of apoptotic programmed cell death involved in development of an anatomical structure", "down regulation of programmed cell death by apoptosis involved in anatomical structure development", "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "down-regulation of apoptotic cell death involved in anatomical structure development", "down-regulation of apoptotic cell death involved in development of an anatomical structure", "down-regulation of apoptotic process involved in anatomical structure development", "down-regulation of apoptotic process involved in development", "down-regulation of apoptotic process involved in development of an anatomical structure", "down-regulation of apoptotic programmed cell death involved in anatomical structure development", "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure", "down-regulation of programmed cell death by apoptosis involved in anatomical structure development", "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "downregulation of apoptotic cell death involved in anatomical structure development", "downregulation of apoptotic cell death involved in development of an anatomical structure", "downregulation of apoptotic process involved in anatomical structure development", "downregulation of apoptotic process involved in development", "downregulation of apoptotic process involved in development of an anatomical structure", "downregulation of apoptotic programmed cell death involved in anatomical structure development", "downregulation of apoptotic programmed cell death involved in development of an anatomical structure", "downregulation of programmed cell death by apoptosis involved in anatomical structure development", "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure", "negative regulation of apoptotic cell death involved in anatomical structure development", "negative regulation of apoptotic cell death involved in development of an anatomical structure", "negative regulation of apoptotic process involved in anatomical structure development", "negative regulation of apoptotic process involved in development of an anatomical structure", "negative regulation of apoptotic programmed cell death involved in anatomical structure development", "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure", "negative regulation of programmed cell death by apoptosis involved in anatomical structure development", "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" ; oboInOwl:hasNarrowSynonym "down regulation of activation of apoptosis involved in anatomical structure development", "down regulation of activation of apoptosis involved in development of an anatomical structure", "down regulation of apoptosis involved in anatomical structure development", "down regulation of apoptosis involved in development of an anatomical structure", "down regulation of apoptosis signaling involved in anatomical structure development", "down regulation of apoptosis signaling involved in development of an anatomical structure", "down regulation of apoptotic program involved in anatomical structure development", "down regulation of apoptotic program involved in development of an anatomical structure", "down regulation of type I programmed cell death involved in anatomical structure development", "down regulation of type I programmed cell death involved in development of an anatomical structure", "down-regulation of activation of apoptosis involved in anatomical structure development", "down-regulation of activation of apoptosis involved in development of an anatomical structure", "down-regulation of apoptosis involved in anatomical structure development", "down-regulation of apoptosis involved in development of an anatomical structure", "down-regulation of apoptosis signaling involved in anatomical structure development", "down-regulation of apoptosis signaling involved in development of an anatomical structure", "down-regulation of apoptotic program involved in anatomical structure development", "down-regulation of apoptotic program involved in development of an anatomical structure", "down-regulation of type I programmed cell death involved in anatomical structure development", "down-regulation of type I programmed cell death involved in development of an anatomical structure", "downregulation of activation of apoptosis involved in anatomical structure development", "downregulation of activation of apoptosis involved in development of an anatomical structure", "downregulation of apoptosis involved in anatomical structure development", "downregulation of apoptosis involved in development of an anatomical structure", "downregulation of apoptosis signaling involved in anatomical structure development", "downregulation of apoptosis signaling involved in development of an anatomical structure", "downregulation of apoptotic program involved in anatomical structure development", "downregulation of apoptotic program involved in development of an anatomical structure", "downregulation of type I programmed cell death involved in anatomical structure development", "downregulation of type I programmed cell death involved in development of an anatomical structure", "inhibition of activation of apoptosis involved in anatomical structure development", "inhibition of activation of apoptosis involved in development of an anatomical structure", "inhibition of apoptosis involved in anatomical structure development", "inhibition of apoptosis involved in development of an anatomical structure", "inhibition of apoptosis signaling involved in anatomical structure development", "inhibition of apoptosis signaling involved in development of an anatomical structure", "inhibition of apoptotic cell death involved in anatomical structure development", "inhibition of apoptotic cell death involved in development of an anatomical structure", "inhibition of apoptotic process involved in anatomical structure development", "inhibition of apoptotic process involved in development", "inhibition of apoptotic process involved in development of an anatomical structure", "inhibition of apoptotic program involved in anatomical structure development", "inhibition of apoptotic program involved in development of an anatomical structure", "inhibition of apoptotic programmed cell death involved in anatomical structure development", "inhibition of apoptotic programmed cell death involved in development of an anatomical structure", "inhibition of programmed cell death by apoptosis involved in anatomical structure development", "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure", "inhibition of type I programmed cell death involved in anatomical structure development", "inhibition of type I programmed cell death involved in development of an anatomical structure", "negative regulation of activation of apoptosis involved in anatomical structure development", "negative regulation of activation of apoptosis involved in development of an anatomical structure", "negative regulation of apoptosis involved in anatomical structure development", "negative regulation of apoptosis involved in development of an anatomical structure", "negative regulation of apoptosis signaling involved in anatomical structure development", "negative regulation of apoptosis signaling involved in development of an anatomical structure", "negative regulation of apoptotic program involved in anatomical structure development", "negative regulation of apoptotic program involved in development of an anatomical structure", "negative regulation of type I programmed cell death involved in anatomical structure development", "negative regulation of type I programmed cell death involved in development of an anatomical structure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of apoptosis activator activity involved in anatomical structure development", "down regulation of apoptosis activator activity involved in development of an anatomical structure", "down regulation of commitment to apoptosis involved in anatomical structure development", "down regulation of commitment to apoptosis involved in development of an anatomical structure", "down regulation of induction of apoptosis by p53 involved in anatomical structure development", "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "down regulation of induction of apoptosis involved in anatomical structure development", "down regulation of induction of apoptosis involved in development of an anatomical structure", "down regulation of signaling (initiator) caspase activity involved in anatomical structure development", "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "down-regulation of apoptosis activator activity involved in anatomical structure development", "down-regulation of apoptosis activator activity involved in development of an anatomical structure", "down-regulation of commitment to apoptosis involved in anatomical structure development", "down-regulation of commitment to apoptosis involved in development of an anatomical structure", "down-regulation of induction of apoptosis by p53 involved in anatomical structure development", "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "down-regulation of induction of apoptosis involved in anatomical structure development", "down-regulation of induction of apoptosis involved in development of an anatomical structure", "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development", "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "downregulation of apoptosis activator activity involved in anatomical structure development", "downregulation of apoptosis activator activity involved in development of an anatomical structure", "downregulation of commitment to apoptosis involved in anatomical structure development", "downregulation of commitment to apoptosis involved in development of an anatomical structure", "downregulation of induction of apoptosis by p53 involved in anatomical structure development", "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure", "downregulation of induction of apoptosis involved in anatomical structure development", "downregulation of induction of apoptosis involved in development of an anatomical structure", "downregulation of signaling (initiator) caspase activity involved in anatomical structure development", "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "inhibition of apoptosis activator activity involved in anatomical structure development", "inhibition of apoptosis activator activity involved in development of an anatomical structure", "inhibition of commitment to apoptosis involved in anatomical structure development", "inhibition of commitment to apoptosis involved in development of an anatomical structure", "inhibition of induction of apoptosis by p53 involved in anatomical structure development", "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure", "inhibition of induction of apoptosis involved in anatomical structure development", "inhibition of induction of apoptosis involved in development of an anatomical structure", "inhibition of signaling (initiator) caspase activity involved in anatomical structure development", "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure", "negative regulation of apoptosis activator activity involved in anatomical structure development", "negative regulation of apoptosis activator activity involved in development of an anatomical structure", "negative regulation of commitment to apoptosis involved in anatomical structure development", "negative regulation of commitment to apoptosis involved in development of an anatomical structure", "negative regulation of induction of apoptosis by p53 involved in anatomical structure development", "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "negative regulation of induction of apoptosis involved in anatomical structure development", "negative regulation of induction of apoptosis involved in development of an anatomical structure", "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development", "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" ; oboInOwl:id "GO:1904746" ; a owl:Class ; rdfs:comment "U4PR86 in PMID:22801495 inferred from mutant phenotype" ; rdfs:label "negative regulation of apoptotic process involved in development" ; rdfs:subClassOf obo:GO_0043066, obo:GO_0051093, obo:GO_1904748, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1902742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_1902742 ] ) ] . obo:GO_1904747 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." ; oboInOwl:created_by "es" ; oboInOwl:creation_date "2015-10-19T14:12:34Z" ; oboInOwl:hasExactSynonym "positive regulation of apoptotic cell death involved in anatomical structure development", "positive regulation of apoptotic cell death involved in development of an anatomical structure", "positive regulation of apoptotic process involved in anatomical structure development", "positive regulation of apoptotic process involved in development of an anatomical structure", "positive regulation of apoptotic programmed cell death involved in anatomical structure development", "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure", "positive regulation of programmed cell death by apoptosis involved in anatomical structure development", "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "up regulation of apoptotic cell death involved in anatomical structure development", "up regulation of apoptotic cell death involved in development of an anatomical structure", "up regulation of apoptotic process involved in anatomical structure development", "up regulation of apoptotic process involved in development", "up regulation of apoptotic process involved in development of an anatomical structure", "up regulation of apoptotic programmed cell death involved in anatomical structure development", "up regulation of apoptotic programmed cell death involved in development of an anatomical structure", "up regulation of programmed cell death by apoptosis involved in anatomical structure development", "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "up-regulation of apoptotic cell death involved in anatomical structure development", "up-regulation of apoptotic cell death involved in development of an anatomical structure", "up-regulation of apoptotic process involved in anatomical structure development", "up-regulation of apoptotic process involved in development", "up-regulation of apoptotic process involved in development of an anatomical structure", "up-regulation of apoptotic programmed cell death involved in anatomical structure development", "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure", "up-regulation of programmed cell death by apoptosis involved in anatomical structure development", "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "upregulation of apoptotic cell death involved in anatomical structure development", "upregulation of apoptotic cell death involved in development of an anatomical structure", "upregulation of apoptotic process involved in anatomical structure development", "upregulation of apoptotic process involved in development", "upregulation of apoptotic process involved in development of an anatomical structure", "upregulation of apoptotic programmed cell death involved in anatomical structure development", "upregulation of apoptotic programmed cell death involved in development of an anatomical structure", "upregulation of programmed cell death by apoptosis involved in anatomical structure development", "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" ; oboInOwl:hasNarrowSynonym "activation of activation of apoptosis involved in anatomical structure development", "activation of activation of apoptosis involved in development of an anatomical structure", "activation of apoptosis involved in anatomical structure development", "activation of apoptosis involved in development of an anatomical structure", "activation of apoptosis signaling involved in anatomical structure development", "activation of apoptosis signaling involved in development of an anatomical structure", "activation of apoptotic cell death involved in anatomical structure development", "activation of apoptotic cell death involved in development of an anatomical structure", "activation of apoptotic process involved in anatomical structure development", "activation of apoptotic process involved in development", "activation of apoptotic process involved in development of an anatomical structure", "activation of apoptotic program involved in anatomical structure development", "activation of apoptotic program involved in development of an anatomical structure", "activation of apoptotic programmed cell death involved in anatomical structure development", "activation of apoptotic programmed cell death involved in development of an anatomical structure", "activation of programmed cell death by apoptosis involved in anatomical structure development", "activation of programmed cell death by apoptosis involved in development of an anatomical structure", "activation of type I programmed cell death involved in anatomical structure development", "activation of type I programmed cell death involved in development of an anatomical structure", "positive regulation of activation of apoptosis involved in anatomical structure development", "positive regulation of activation of apoptosis involved in development of an anatomical structure", "positive regulation of apoptosis involved in anatomical structure development", "positive regulation of apoptosis involved in development of an anatomical structure", "positive regulation of apoptosis signaling involved in anatomical structure development", "positive regulation of apoptosis signaling involved in development of an anatomical structure", "positive regulation of apoptotic program involved in anatomical structure development", "positive regulation of apoptotic program involved in development of an anatomical structure", "positive regulation of type I programmed cell death involved in anatomical structure development", "positive regulation of type I programmed cell death involved in development of an anatomical structure", "up regulation of activation of apoptosis involved in anatomical structure development", "up regulation of activation of apoptosis involved in development of an anatomical structure", "up regulation of apoptosis involved in anatomical structure development", "up regulation of apoptosis involved in development of an anatomical structure", "up regulation of apoptosis signaling involved in anatomical structure development", "up regulation of apoptosis signaling involved in development of an anatomical structure", "up regulation of apoptotic program involved in anatomical structure development", "up regulation of apoptotic program involved in development of an anatomical structure", "up regulation of type I programmed cell death involved in anatomical structure development", "up regulation of type I programmed cell death involved in development of an anatomical structure", "up-regulation of activation of apoptosis involved in anatomical structure development", "up-regulation of activation of apoptosis involved in development of an anatomical structure", "up-regulation of apoptosis involved in anatomical structure development", "up-regulation of apoptosis involved in development of an anatomical structure", "up-regulation of apoptosis signaling involved in anatomical structure development", "up-regulation of apoptosis signaling involved in development of an anatomical structure", "up-regulation of apoptotic program involved in anatomical structure development", "up-regulation of apoptotic program involved in development of an anatomical structure", "up-regulation of type I programmed cell death involved in anatomical structure development", "up-regulation of type I programmed cell death involved in development of an anatomical structure", "upregulation of activation of apoptosis involved in anatomical structure development", "upregulation of activation of apoptosis involved in development of an anatomical structure", "upregulation of apoptosis involved in anatomical structure development", "upregulation of apoptosis involved in development of an anatomical structure", "upregulation of apoptosis signaling involved in anatomical structure development", "upregulation of apoptosis signaling involved in development of an anatomical structure", "upregulation of apoptotic program involved in anatomical structure development", "upregulation of apoptotic program involved in development of an anatomical structure", "upregulation of type I programmed cell death involved in anatomical structure development", "upregulation of type I programmed cell death involved in development of an anatomical structure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of apoptosis activator activity involved in anatomical structure development", "activation of apoptosis activator activity involved in development of an anatomical structure", "activation of commitment to apoptosis involved in anatomical structure development", "activation of commitment to apoptosis involved in development of an anatomical structure", "activation of induction of apoptosis by p53 involved in anatomical structure development", "activation of induction of apoptosis by p53 involved in development of an anatomical structure", "activation of induction of apoptosis involved in anatomical structure development", "activation of induction of apoptosis involved in development of an anatomical structure", "activation of signaling (initiator) caspase activity involved in anatomical structure development", "activation of signaling (initiator) caspase activity involved in development of an anatomical structure", "positive regulation of apoptosis activator activity involved in anatomical structure development", "positive regulation of apoptosis activator activity involved in development of an anatomical structure", "positive regulation of commitment to apoptosis involved in anatomical structure development", "positive regulation of commitment to apoptosis involved in development of an anatomical structure", "positive regulation of induction of apoptosis by p53 involved in anatomical structure development", "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "positive regulation of induction of apoptosis involved in anatomical structure development", "positive regulation of induction of apoptosis involved in development of an anatomical structure", "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development", "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "up regulation of apoptosis activator activity involved in anatomical structure development", "up regulation of apoptosis activator activity involved in development of an anatomical structure", "up regulation of commitment to apoptosis involved in anatomical structure development", "up regulation of commitment to apoptosis involved in development of an anatomical structure", "up regulation of induction of apoptosis by p53 involved in anatomical structure development", "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "up regulation of induction of apoptosis involved in anatomical structure development", "up regulation of induction of apoptosis involved in development of an anatomical structure", "up regulation of signaling (initiator) caspase activity involved in anatomical structure development", "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "up-regulation of apoptosis activator activity involved in anatomical structure development", "up-regulation of apoptosis activator activity involved in development of an anatomical structure", "up-regulation of commitment to apoptosis involved in anatomical structure development", "up-regulation of commitment to apoptosis involved in development of an anatomical structure", "up-regulation of induction of apoptosis by p53 involved in anatomical structure development", "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "up-regulation of induction of apoptosis involved in anatomical structure development", "up-regulation of induction of apoptosis involved in development of an anatomical structure", "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development", "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "upregulation of apoptosis activator activity involved in anatomical structure development", "upregulation of apoptosis activator activity involved in development of an anatomical structure", "upregulation of commitment to apoptosis involved in anatomical structure development", "upregulation of commitment to apoptosis involved in development of an anatomical structure", "upregulation of induction of apoptosis by p53 involved in anatomical structure development", "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure", "upregulation of induction of apoptosis involved in anatomical structure development", "upregulation of induction of apoptosis involved in development of an anatomical structure", "upregulation of signaling (initiator) caspase activity involved in anatomical structure development", "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" ; oboInOwl:id "GO:1904747" ; a owl:Class ; rdfs:comment "U4PR86 in PMID:22801495 inferred from mutant phenotype" ; rdfs:label "positive regulation of apoptotic process involved in development" ; rdfs:subClassOf obo:GO_0043065, obo:GO_0051094, obo:GO_1904748, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1902742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_1902742 ] ) ] . obo:GO_1904748 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." ; oboInOwl:created_by "es" ; oboInOwl:creation_date "2015-10-19T15:02:28Z" ; oboInOwl:hasExactSynonym "regulation of apoptotic cell death involved in anatomical structure development", "regulation of apoptotic cell death involved in development of an anatomical structure", "regulation of apoptotic process involved in anatomical structure development", "regulation of apoptotic process involved in development of an anatomical structure", "regulation of apoptotic programmed cell death involved in anatomical structure development", "regulation of apoptotic programmed cell death involved in development of an anatomical structure", "regulation of programmed cell death by apoptosis involved in anatomical structure development", "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" ; oboInOwl:hasNarrowSynonym "regulation of activation of apoptosis involved in anatomical structure development", "regulation of activation of apoptosis involved in development of an anatomical structure", "regulation of apoptosis involved in anatomical structure development", "regulation of apoptosis involved in development of an anatomical structure", "regulation of apoptosis signaling involved in anatomical structure development", "regulation of apoptosis signaling involved in development of an anatomical structure", "regulation of apoptotic program involved in anatomical structure development", "regulation of apoptotic program involved in development of an anatomical structure", "regulation of type I programmed cell death involved in anatomical structure development", "regulation of type I programmed cell death involved in development of an anatomical structure" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of apoptosis activator activity involved in anatomical structure development", "regulation of apoptosis activator activity involved in development of an anatomical structure", "regulation of commitment to apoptosis involved in anatomical structure development", "regulation of commitment to apoptosis involved in development of an anatomical structure", "regulation of induction of apoptosis by p53 involved in anatomical structure development", "regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "regulation of induction of apoptosis involved in anatomical structure development", "regulation of induction of apoptosis involved in development of an anatomical structure", "regulation of signaling (initiator) caspase activity involved in anatomical structure development", "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" ; oboInOwl:id "GO:1904748" ; a owl:Class ; rdfs:comment "Q10943 in PMID:22801495, inferred from mutant phenotype" ; rdfs:label "regulation of apoptotic process involved in development" ; rdfs:subClassOf obo:GO_0042981, obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1902742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_1902742 ] ) ] . obo:GO_1904949 obo:IAO_0000115 "A protein complex which is capable of ATPase activity." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-02-04T22:13:32Z" ; oboInOwl:hasNarrowSynonym "VPS4 complex" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:1904949" ; a owl:Class ; rdfs:comment "An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay)." ; rdfs:label "ATPase complex" ; rdfs:subClassOf obo:GO_1902494 . obo:GO_1904950 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." ; oboInOwl:created_by "mec" ; oboInOwl:creation_date "2016-02-05T09:59:24Z" ; oboInOwl:hasExactSynonym "down regulation of establishment of protein localisation", "down regulation of establishment of protein localization", "down regulation of protein positioning", "down regulation of protein recruitment", "down-regulation of establishment of protein localisation", "down-regulation of establishment of protein localization", "down-regulation of protein positioning", "down-regulation of protein recruitment", "downregulation of establishment of protein localisation", "downregulation of establishment of protein localization", "downregulation of protein positioning", "downregulation of protein recruitment", "negative regulation of establishment of protein localisation", "negative regulation of protein positioning", "negative regulation of protein recruitment" ; oboInOwl:hasNarrowSynonym "inhibition of establishment of protein localisation", "inhibition of establishment of protein localization", "inhibition of protein positioning", "inhibition of protein recruitment" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904950" ; a owl:Class ; rdfs:label "negative regulation of establishment of protein localization" ; rdfs:subClassOf obo:GO_0070201, obo:GO_1903828, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045184 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0045184 ] ) ] . obo:GO_1904951 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." ; oboInOwl:created_by "mec" ; oboInOwl:creation_date "2016-02-05T09:59:32Z" ; oboInOwl:hasExactSynonym "positive regulation of establishment of protein localisation", "positive regulation of protein positioning", "positive regulation of protein recruitment", "up regulation of establishment of protein localisation", "up regulation of establishment of protein localization", "up regulation of protein positioning", "up regulation of protein recruitment", "up-regulation of establishment of protein localisation", "up-regulation of establishment of protein localization", "up-regulation of protein positioning", "up-regulation of protein recruitment", "upregulation of establishment of protein localisation", "upregulation of establishment of protein localization", "upregulation of protein positioning", "upregulation of protein recruitment" ; oboInOwl:hasNarrowSynonym "activation of establishment of protein localisation", "activation of establishment of protein localization", "activation of protein positioning", "activation of protein recruitment" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1904951" ; a owl:Class ; rdfs:label "positive regulation of establishment of protein localization" ; rdfs:subClassOf obo:GO_0070201, obo:GO_1903829, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045184 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0045184 ] ) ] . obo:GO_1905038 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2016-03-08T20:41:32Z" ; oboInOwl:hasExactSynonym "regulation of membrane lipid metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905038" ; a owl:Class ; rdfs:label "regulation of membrane lipid metabolic process" ; rdfs:subClassOf obo:GO_0019216, obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006643 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006643 ] ) ] . obo:GO_1905082 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2016-03-25T17:37:03Z" ; oboInOwl:hasExactSynonym "regulation of mitochondrial translation elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905082" ; a owl:Class ; rdfs:label "regulation of mitochondrial translational elongation" ; rdfs:subClassOf obo:GO_0006448, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070125 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0070125 ] ) ] . obo:GO_1905083 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2016-03-25T17:37:13Z" ; oboInOwl:hasExactSynonym "down regulation of mitochondrial translation elongation", "down regulation of mitochondrial translational elongation", "down-regulation of mitochondrial translation elongation", "down-regulation of mitochondrial translational elongation", "downregulation of mitochondrial translation elongation", "downregulation of mitochondrial translational elongation", "negative regulation of mitochondrial translation elongation" ; oboInOwl:hasNarrowSynonym "inhibition of mitochondrial translation elongation", "inhibition of mitochondrial translational elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905083" ; a owl:Class ; rdfs:label "negative regulation of mitochondrial translational elongation" ; rdfs:subClassOf obo:GO_0045900, obo:GO_0070130, obo:GO_1905082, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070125 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0070125 ] ) ] . obo:GO_1905084 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." ; oboInOwl:created_by "hjd" ; oboInOwl:creation_date "2016-03-25T17:37:22Z" ; oboInOwl:hasExactSynonym "positive regulation of mitochondrial translation elongation", "up regulation of mitochondrial translation elongation", "up regulation of mitochondrial translational elongation", "up-regulation of mitochondrial translation elongation", "up-regulation of mitochondrial translational elongation", "upregulation of mitochondrial translation elongation", "upregulation of mitochondrial translational elongation" ; oboInOwl:hasNarrowSynonym "activation of mitochondrial translation elongation", "activation of mitochondrial translational elongation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905084" ; a owl:Class ; rdfs:label "positive regulation of mitochondrial translational elongation" ; rdfs:subClassOf obo:GO_0045901, obo:GO_1905082, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070125 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0070125 ] ) ] . obo:GO_1905114 obo:IAO_0000115 "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." ; oboInOwl:created_by "dos" ; oboInOwl:creation_date "2016-04-06T16:59:57Z" ; oboInOwl:hasExactSynonym "cell surface receptor linked signal transduction involved in cell-cell signaling", "cell surface receptor linked signal transduction involved in cell-cell signalling", "cell surface receptor linked signaling pathway involved in cell-cell signaling", "cell surface receptor linked signaling pathway involved in cell-cell signalling", "cell surface receptor linked signalling pathway involved in cell-cell signaling", "cell surface receptor linked signalling pathway involved in cell-cell signalling", "cell surface receptor signaling pathway involved in cell-cell signalling" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905114" ; a owl:Class ; rdfs:label "cell surface receptor signaling pathway involved in cell-cell signaling" ; rdfs:subClassOf obo:GO_0007166, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007267 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0007166 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0007267 ] ) ] . obo:GO_1905153 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of membrane invagination." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2016-04-18T15:43:54Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905153" ; a owl:Class ; rdfs:label "regulation of membrane invagination" ; rdfs:subClassOf obo:GO_0051128, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010324 ] ) ] . obo:GO_1905154 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2016-04-18T15:44:04Z" ; oboInOwl:hasExactSynonym "down regulation of membrane invagination", "down-regulation of membrane invagination", "downregulation of membrane invagination" ; oboInOwl:hasNarrowSynonym "inhibition of membrane invagination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905154" ; a owl:Class ; rdfs:label "negative regulation of membrane invagination" ; rdfs:subClassOf obo:GO_0051129, obo:GO_1905153, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010324 ] ) ] . obo:GO_1905155 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of membrane invagination." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2016-04-18T15:44:12Z" ; oboInOwl:hasExactSynonym "up regulation of membrane invagination", "up-regulation of membrane invagination", "upregulation of membrane invagination" ; oboInOwl:hasNarrowSynonym "activation of membrane invagination" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905155" ; a owl:Class ; rdfs:label "positive regulation of membrane invagination" ; rdfs:subClassOf obo:GO_0051130, obo:GO_1905153, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010324 ] ) ] . obo:GO_1905213 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2016-06-03T08:41:08Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905213" ; a owl:Class ; rdfs:label "negative regulation of mitotic chromosome condensation" ; rdfs:subClassOf obo:GO_0010948, obo:GO_1902340, obo:GO_1903379, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007076 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007076 ] ) ] . obo:GO_1905268 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22766"^^xsd:anyURI ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-06-15T20:14:47Z" ; oboInOwl:hasAlternativeId "GO:0045798", "GO:1903309" ; oboInOwl:hasExactSynonym "down regulation of chromatin organisation", "down regulation of chromatin organization", "down regulation of establishment or maintenance of chromatin architecture", "down-regulation of chromatin organisation", "down-regulation of chromatin organization", "down-regulation of establishment or maintenance of chromatin architecture", "downregulation of chromatin organisation", "downregulation of chromatin organization", "downregulation of establishment or maintenance of chromatin architecture", "negative regulation of chromatin assembly/disassembly", "negative regulation of chromatin organisation", "negative regulation of establishment or maintenance of chromatin architecture" ; oboInOwl:hasNarrowSynonym "inhibition of chromatin assembly or disassembly", "inhibition of chromatin organisation", "inhibition of chromatin organization", "inhibition of establishment or maintenance of chromatin architecture" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of chromatin assembly or disassembly", "down-regulation of chromatin assembly or disassembly", "downregulation of chromatin assembly or disassembly", "negative regulation of chromatin assembly or disassembly", "negative regulation of chromatin modification" ; oboInOwl:id "GO:1905268" ; a owl:Class ; rdfs:label "negative regulation of chromatin organization" ; rdfs:subClassOf obo:GO_0051129, obo:GO_1902275, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006325 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006325 ] ) ] . obo:GO_1905269 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of chromatin organization." ; obo:IAO_0000233 "https://github.com/geneontology/go-ontology/issues/22766"^^xsd:anyURI ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-06-15T20:14:56Z" ; oboInOwl:hasAlternativeId "GO:0045799", "GO:1903310" ; oboInOwl:hasExactSynonym "positive regulation of chromatin organisation", "positive regulation of establishment or maintenance of chromatin architecture", "up regulation of chromatin organisation", "up regulation of chromatin organization", "up regulation of establishment or maintenance of chromatin architecture", "up-regulation of chromatin organisation", "up-regulation of chromatin organization", "up-regulation of establishment or maintenance of chromatin architecture", "upregulation of chromatin assembly or disassembly", "upregulation of chromatin organisation", "upregulation of chromatin organization", "upregulation of establishment or maintenance of chromatin architecture" ; oboInOwl:hasNarrowSynonym "activation of chromatin assembly or disassembly", "activation of chromatin organisation", "activation of chromatin organization", "activation of establishment or maintenance of chromatin architecture", "stimulation of chromatin assembly or disassembly" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of chromatin assembly or disassembly", "positive regulation of chromatin assembly/disassembly", "positive regulation of chromatin modification", "up regulation of chromatin assembly or disassembly", "up-regulation of chromatin assembly or disassembly" ; oboInOwl:id "GO:1905269" ; a owl:Class ; rdfs:label "positive regulation of chromatin organization" ; rdfs:subClassOf obo:GO_1902275, obo:GO_2001252, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006325 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006325 ] ) ] . obo:GO_1905276 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of epithelial tube formation." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-06-20T09:35:41Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905276" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "regulation of epithelial tube formation" ; rdfs:subClassOf obo:GO_1905330, obo:GO_2000026, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072175 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072175 ] ) ] . obo:GO_1905277 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-06-20T09:35:49Z" ; oboInOwl:hasExactSynonym "down regulation of epithelial tube formation", "down-regulation of epithelial tube formation", "downregulation of epithelial tube formation" ; oboInOwl:hasNarrowSynonym "inhibition of epithelial tube formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905277" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "negative regulation of epithelial tube formation" ; rdfs:subClassOf obo:GO_0051241, obo:GO_1905276, obo:GO_1905331, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072175 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072175 ] ) ] . obo:GO_1905278 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-06-20T09:35:57Z" ; oboInOwl:hasExactSynonym "up regulation of epithelial tube formation", "up-regulation of epithelial tube formation", "upregulation of epithelial tube formation" ; oboInOwl:hasNarrowSynonym "activation of epithelial tube formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905278" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "positive regulation of epithelial tube formation" ; rdfs:subClassOf obo:GO_0051240, obo:GO_1905276, obo:GO_1905332, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072175 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072175 ] ) ] . obo:GO_1905330 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-07-22T07:13:49Z" ; oboInOwl:hasExactSynonym "regulation of epithelium morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905330" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "regulation of morphogenesis of an epithelium" ; rdfs:subClassOf obo:GO_0022603, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002009 ] ) ] . obo:GO_1905331 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-07-22T07:13:57Z" ; oboInOwl:hasExactSynonym "down regulation of epithelium morphogenesis", "down regulation of morphogenesis of an epithelium", "down-regulation of epithelium morphogenesis", "down-regulation of morphogenesis of an epithelium", "downregulation of epithelium morphogenesis", "downregulation of morphogenesis of an epithelium", "negative regulation of epithelium morphogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of epithelium morphogenesis", "inhibition of morphogenesis of an epithelium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905331" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "negative regulation of morphogenesis of an epithelium" ; rdfs:subClassOf obo:GO_0051093, obo:GO_1905330, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002009 ] ) ] . obo:GO_1905332 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2016-07-22T07:14:05Z" ; oboInOwl:hasExactSynonym "positive regulation of epithelium morphogenesis", "up regulation of epithelium morphogenesis", "up regulation of morphogenesis of an epithelium", "up-regulation of epithelium morphogenesis", "up-regulation of morphogenesis of an epithelium", "upregulation of epithelium morphogenesis", "upregulation of morphogenesis of an epithelium" ; oboInOwl:hasNarrowSynonym "activation of epithelium morphogenesis", "activation of morphogenesis of an epithelium" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905332" ; a owl:Class ; rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ; rdfs:label "positive regulation of morphogenesis of an epithelium" ; rdfs:subClassOf obo:GO_0051094, obo:GO_1905330, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002009 ] ) ] . obo:GO_1905349 obo:IAO_0000115 "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-08-04T14:49:43Z" ; oboInOwl:hasExactSynonym "cilial transition zone assembly", "cilial transition zone formation", "ciliary transition zone formation", "cilium transition zone assembly", "cilium transition zone formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905349" ; a owl:Class ; rdfs:label "ciliary transition zone assembly" ; rdfs:subClassOf obo:GO_0022607, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0060271 ] . obo:GO_1905427 obo:IAO_0000115 "Any intracellular signal transduction that is involved in positive regulation of cell growth." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2016-09-07T18:15:01Z" ; oboInOwl:hasExactSynonym "intracellular signal transduction involved in up regulation of cell growth", "intracellular signal transduction involved in up-regulation of cell growth", "intracellular signal transduction involved in upregulation of cell growth", "intracellular signaling chain involved in positive regulation of cell growth", "intracellular signaling chain involved in up regulation of cell growth", "intracellular signaling chain involved in up-regulation of cell growth", "intracellular signaling chain involved in upregulation of cell growth" ; oboInOwl:hasNarrowSynonym "intracellular protein kinase cascade involved in activation of cell growth", "intracellular protein kinase cascade involved in positive regulation of cell growth", "intracellular protein kinase cascade involved in stimulation of cell growth", "intracellular protein kinase cascade involved in up regulation of cell growth", "intracellular protein kinase cascade involved in up-regulation of cell growth", "intracellular protein kinase cascade involved in upregulation of cell growth", "intracellular signal transduction involved in activation of cell growth", "intracellular signal transduction involved in stimulation of cell growth", "intracellular signal transduction pathway involved in activation of cell growth", "intracellular signal transduction pathway involved in positive regulation of cell growth", "intracellular signal transduction pathway involved in stimulation of cell growth", "intracellular signal transduction pathway involved in up regulation of cell growth", "intracellular signal transduction pathway involved in up-regulation of cell growth", "intracellular signal transduction pathway involved in upregulation of cell growth", "intracellular signaling chain involved in activation of cell growth", "intracellular signaling chain involved in stimulation of cell growth", "protein kinase cascade involved in activation of cell growth", "protein kinase cascade involved in positive regulation of cell growth", "protein kinase cascade involved in stimulation of cell growth", "protein kinase cascade involved in up regulation of cell growth", "protein kinase cascade involved in up-regulation of cell growth", "protein kinase cascade involved in upregulation of cell growth", "signal transmission via intracellular cascade involved in activation of cell growth", "signal transmission via intracellular cascade involved in positive regulation of cell growth", "signal transmission via intracellular cascade involved in stimulation of cell growth", "signal transmission via intracellular cascade involved in up regulation of cell growth", "signal transmission via intracellular cascade involved in up-regulation of cell growth", "signal transmission via intracellular cascade involved in upregulation of cell growth" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "intracellular signaling cascade involved in activation of cell growth", "intracellular signaling cascade involved in positive regulation of cell growth", "intracellular signaling cascade involved in stimulation of cell growth", "intracellular signaling cascade involved in up regulation of cell growth", "intracellular signaling cascade involved in up-regulation of cell growth", "intracellular signaling cascade involved in upregulation of cell growth", "intracellular signaling pathway involved in activation of cell growth", "intracellular signaling pathway involved in positive regulation of cell growth", "intracellular signaling pathway involved in stimulation of cell growth", "intracellular signaling pathway involved in up regulation of cell growth", "intracellular signaling pathway involved in up-regulation of cell growth", "intracellular signaling pathway involved in upregulation of cell growth", "signal transduction via intracellular signaling cascade involved in activation of cell growth", "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth", "signal transduction via intracellular signaling cascade involved in stimulation of cell growth", "signal transduction via intracellular signaling cascade involved in up regulation of cell growth", "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth", "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" ; oboInOwl:id "GO:1905427" ; a owl:Class ; rdfs:label "intracellular signal transduction involved in positive regulation of cell growth" ; rdfs:subClassOf obo:GO_0035556, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030307 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0035556 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0030307 ] ) ] . obo:GO_1905503 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of motile cilium assembly." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2016-09-27T18:27:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of motile primary cilia assembly", "regulation of motile primary cilia formation", "regulation of motile primary cilium assembly", "regulation of motile primary cilium formation", "regulation of nodal cilium assembly", "regulation of nodal cilium formation" ; oboInOwl:id "GO:1905503" ; a owl:Class ; rdfs:label "regulation of motile cilium assembly" ; rdfs:subClassOf obo:GO_1902017, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0044458 ] ) ] . obo:GO_1905504 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2016-09-27T18:27:55Z" ; oboInOwl:hasNarrowSynonym "inhibition of motile primary cilia assembly", "inhibition of motile primary cilia formation", "inhibition of motile primary cilium assembly", "inhibition of motile primary cilium formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "down regulation of motile primary cilia assembly", "down regulation of motile primary cilia formation", "down regulation of motile primary cilium assembly", "down regulation of motile primary cilium formation", "down regulation of nodal cilium assembly", "down regulation of nodal cilium formation", "down-regulation of motile primary cilia assembly", "down-regulation of motile primary cilia formation", "down-regulation of motile primary cilium assembly", "down-regulation of motile primary cilium formation", "down-regulation of nodal cilium assembly", "down-regulation of nodal cilium formation", "downregulation of motile primary cilia assembly", "downregulation of motile primary cilia formation", "downregulation of motile primary cilium assembly", "downregulation of motile primary cilium formation", "downregulation of nodal cilium assembly", "downregulation of nodal cilium formation", "inhibition of nodal cilium assembly", "inhibition of nodal cilium formation", "negative regulation of motile primary cilia assembly", "negative regulation of motile primary cilia formation", "negative regulation of motile primary cilium assembly", "negative regulation of motile primary cilium formation", "negative regulation of nodal cilium assembly", "negative regulation of nodal cilium formation" ; oboInOwl:id "GO:1905504" ; a owl:Class ; rdfs:label "negative regulation of motile cilium assembly" ; rdfs:subClassOf obo:GO_1902018, obo:GO_1905503, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0044458 ] ) ] . obo:GO_1905505 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." ; oboInOwl:created_by "krc" ; oboInOwl:creation_date "2016-09-27T18:28:03Z" ; oboInOwl:hasNarrowSynonym "activation of motile primary cilia assembly", "activation of motile primary cilia formation", "activation of motile primary cilium assembly", "activation of motile primary cilium formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "activation of nodal cilium assembly", "activation of nodal cilium formation", "positive regulation of motile primary cilia assembly", "positive regulation of motile primary cilia formation", "positive regulation of motile primary cilium assembly", "positive regulation of motile primary cilium formation", "positive regulation of nodal cilium assembly", "positive regulation of nodal cilium formation", "up regulation of motile primary cilia assembly", "up regulation of motile primary cilia formation", "up regulation of motile primary cilium assembly", "up regulation of motile primary cilium formation", "up regulation of nodal cilium assembly", "up regulation of nodal cilium formation", "up-regulation of motile primary cilia assembly", "up-regulation of motile primary cilia formation", "up-regulation of motile primary cilium assembly", "up-regulation of motile primary cilium formation", "up-regulation of nodal cilium assembly", "up-regulation of nodal cilium formation", "upregulation of motile primary cilia assembly", "upregulation of motile primary cilia formation", "upregulation of motile primary cilium assembly", "upregulation of motile primary cilium formation", "upregulation of nodal cilium assembly", "upregulation of nodal cilium formation" ; oboInOwl:id "GO:1905505" ; a owl:Class ; rdfs:label "positive regulation of motile cilium assembly" ; rdfs:subClassOf obo:GO_0045724, obo:GO_1905503, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044458 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0044458 ] ) ] . obo:GO_1905516 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of fertilization." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2016-09-30T14:32:32Z" ; oboInOwl:hasExactSynonym "positive regulation of syngamy", "up regulation of fertilization", "up regulation of syngamy", "up-regulation of fertilization", "up-regulation of syngamy", "upregulation of fertilization", "upregulation of syngamy" ; oboInOwl:hasNarrowSynonym "activation of fertilization", "activation of syngamy" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905516" ; a owl:Class ; rdfs:label "positive regulation of fertilization" ; rdfs:subClassOf obo:GO_0080154, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0009566 ] ) ] . obo:GO_1905553 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood vessel branching." ; oboInOwl:created_by "nc" ; oboInOwl:creation_date "2016-10-12T14:19:33Z" ; oboInOwl:hasExactSynonym "regulation of branching involved in blood vessel morphogenesis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905553" ; a owl:Class ; rdfs:label "regulation of blood vessel branching" ; rdfs:subClassOf obo:GO_0045765, obo:GO_0060688, obo:GO_1905330, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001569 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001569 ] ) ] . obo:GO_1905554 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." ; oboInOwl:created_by "nc" ; oboInOwl:creation_date "2016-10-12T14:19:41Z" ; oboInOwl:hasExactSynonym "down regulation of branching involved in blood vessel morphogenesis", "down regulation of patterning of blood vessels", "down-regulation of branching involved in blood vessel morphogenesis", "down-regulation of patterning of blood vessels", "downregulation of branching involved in blood vessel morphogenesis", "downregulation of patterning of blood vessels", "negative regulation of branching involved in blood vessel morphogenesis" ; oboInOwl:hasNarrowSynonym "inhibition of branching involved in blood vessel morphogenesis", "inhibition of patterning of blood vessels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905554" ; a owl:Class ; rdfs:label "negative regulation of vessel branching" ; rdfs:subClassOf obo:GO_0016525, obo:GO_1905331, obo:GO_1905553, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001569 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001569 ] ) ] . obo:GO_1905555 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood vessel branching." ; oboInOwl:created_by "nc" ; oboInOwl:creation_date "2016-10-12T14:19:49Z" ; oboInOwl:hasExactSynonym "positive regulation of branching involved in blood vessel morphogenesis", "up regulation of branching involved in blood vessel morphogenesis", "up regulation of patterning of blood vessels", "up-regulation of branching involved in blood vessel morphogenesis", "up-regulation of patterning of blood vessels", "upregulation of branching involved in blood vessel morphogenesis", "upregulation of patterning of blood vessels" ; oboInOwl:hasNarrowSynonym "activation of branching involved in blood vessel morphogenesis", "activation of patterning of blood vessels" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905555" ; a owl:Class ; rdfs:label "positive regulation of blood vessel branching" ; rdfs:subClassOf obo:GO_0045766, obo:GO_1905332, obo:GO_1905553, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001569 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001569 ] ) ] . obo:GO_1905747 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." ; oboInOwl:created_by "pga" ; oboInOwl:creation_date "2016-12-09T10:24:00Z" ; oboInOwl:hasExactSynonym "down regulation of saliva secretion", "down regulation of salivation", "down-regulation of saliva secretion", "down-regulation of salivation", "downregulation of saliva secretion", "downregulation of salivation", "negative regulation of salivation" ; oboInOwl:hasNarrowSynonym "inhibition of saliva secretion", "inhibition of salivation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905747" ; a owl:Class ; rdfs:label "negative regulation of saliva secretion" ; rdfs:subClassOf obo:GO_0046877, obo:GO_0051048, obo:GO_0060457, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046541 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0046541 ] ) ] . obo:GO_1905787 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-09T15:11:04Z" ; oboInOwl:hasExactSynonym "regulation of perception of touch, detection of mechanical stimulus", "regulation of perception of touch, sensory detection of mechanical stimulus", "regulation of perception of touch, sensory transduction of mechanical stimulus", "regulation of sensory detection of mechanical stimulus during perception of touch", "regulation of sensory transduction of mechanical stimulus during perception of touch", "regulation of tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905787" ; a owl:Class ; rdfs:label "regulation of detection of mechanical stimulus involved in sensory perception of touch" ; rdfs:subClassOf obo:GO_0032101, obo:GO_0051931, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0050976 ] ) ] . obo:GO_1905788 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-09T15:11:14Z" ; oboInOwl:hasExactSynonym "down regulation of detection of mechanical stimulus involved in sensory perception of touch", "down regulation of perception of touch, detection of mechanical stimulus", "down regulation of perception of touch, sensory detection of mechanical stimulus", "down regulation of perception of touch, sensory transduction of mechanical stimulus", "down regulation of sensory detection of mechanical stimulus during perception of touch", "down regulation of sensory transduction of mechanical stimulus during perception of touch", "down regulation of tactition, sensory detection of mechanical stimulus", "down-regulation of detection of mechanical stimulus involved in sensory perception of touch", "down-regulation of perception of touch, detection of mechanical stimulus", "down-regulation of perception of touch, sensory detection of mechanical stimulus", "down-regulation of perception of touch, sensory transduction of mechanical stimulus", "down-regulation of sensory detection of mechanical stimulus during perception of touch", "down-regulation of sensory transduction of mechanical stimulus during perception of touch", "down-regulation of tactition, sensory detection of mechanical stimulus", "downregulation of detection of mechanical stimulus involved in sensory perception of touch", "downregulation of perception of touch, detection of mechanical stimulus", "downregulation of perception of touch, sensory detection of mechanical stimulus", "downregulation of perception of touch, sensory transduction of mechanical stimulus", "downregulation of sensory detection of mechanical stimulus during perception of touch", "downregulation of sensory transduction of mechanical stimulus during perception of touch", "downregulation of tactition, sensory detection of mechanical stimulus", "negative regulation of perception of touch, detection of mechanical stimulus", "negative regulation of perception of touch, sensory detection of mechanical stimulus", "negative regulation of perception of touch, sensory transduction of mechanical stimulus", "negative regulation of sensory detection of mechanical stimulus during perception of touch", "negative regulation of sensory transduction of mechanical stimulus during perception of touch", "negative regulation of tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasNarrowSynonym "inhibition of detection of mechanical stimulus involved in sensory perception of touch", "inhibition of perception of touch, detection of mechanical stimulus", "inhibition of perception of touch, sensory detection of mechanical stimulus", "inhibition of perception of touch, sensory transduction of mechanical stimulus", "inhibition of sensory detection of mechanical stimulus during perception of touch", "inhibition of sensory transduction of mechanical stimulus during perception of touch", "inhibition of tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905788" ; a owl:Class ; rdfs:label "negative regulation of detection of mechanical stimulus involved in sensory perception of touch" ; rdfs:subClassOf obo:GO_0031645, obo:GO_0032102, obo:GO_1905787, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0050976 ] ) ] . obo:GO_1905789 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-09T15:11:23Z" ; oboInOwl:hasExactSynonym "positive regulation of perception of touch, detection of mechanical stimulus", "positive regulation of perception of touch, sensory detection of mechanical stimulus", "positive regulation of perception of touch, sensory transduction of mechanical stimulus", "positive regulation of sensory detection of mechanical stimulus during perception of touch", "positive regulation of sensory transduction of mechanical stimulus during perception of touch", "positive regulation of tactition, sensory detection of mechanical stimulus", "up regulation of detection of mechanical stimulus involved in sensory perception of touch", "up regulation of perception of touch, detection of mechanical stimulus", "up regulation of perception of touch, sensory detection of mechanical stimulus", "up regulation of perception of touch, sensory transduction of mechanical stimulus", "up regulation of sensory detection of mechanical stimulus during perception of touch", "up regulation of sensory transduction of mechanical stimulus during perception of touch", "up regulation of tactition, sensory detection of mechanical stimulus", "up-regulation of detection of mechanical stimulus involved in sensory perception of touch", "up-regulation of perception of touch, detection of mechanical stimulus", "up-regulation of perception of touch, sensory detection of mechanical stimulus", "up-regulation of perception of touch, sensory transduction of mechanical stimulus", "up-regulation of sensory detection of mechanical stimulus during perception of touch", "up-regulation of sensory transduction of mechanical stimulus during perception of touch", "up-regulation of tactition, sensory detection of mechanical stimulus", "upregulation of detection of mechanical stimulus involved in sensory perception of touch", "upregulation of perception of touch, detection of mechanical stimulus", "upregulation of perception of touch, sensory detection of mechanical stimulus", "upregulation of perception of touch, sensory transduction of mechanical stimulus", "upregulation of sensory detection of mechanical stimulus during perception of touch", "upregulation of sensory transduction of mechanical stimulus during perception of touch", "upregulation of tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasNarrowSynonym "activation of detection of mechanical stimulus involved in sensory perception of touch", "activation of perception of touch, detection of mechanical stimulus", "activation of perception of touch, sensory detection of mechanical stimulus", "activation of perception of touch, sensory transduction of mechanical stimulus", "activation of sensory detection of mechanical stimulus during perception of touch", "activation of sensory transduction of mechanical stimulus during perception of touch", "activation of tactition, sensory detection of mechanical stimulus" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905789" ; a owl:Class ; rdfs:label "positive regulation of detection of mechanical stimulus involved in sensory perception of touch" ; rdfs:subClassOf obo:GO_0031646, obo:GO_0032103, obo:GO_1905787, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0050976 ] ) ] . obo:GO_1905821 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of chromosome condensation." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2017-01-13T14:13:44Z" ; oboInOwl:hasExactSynonym "positive regulation of eukaryotic chromosome condensation", "positive regulation of nuclear chromosome condensation", "up regulation of chromosome condensation", "up regulation of eukaryotic chromosome condensation", "up regulation of nuclear chromosome condensation", "up-regulation of chromosome condensation", "up-regulation of eukaryotic chromosome condensation", "up-regulation of nuclear chromosome condensation", "upregulation of chromosome condensation", "upregulation of eukaryotic chromosome condensation", "upregulation of nuclear chromosome condensation" ; oboInOwl:hasNarrowSynonym "activation of chromosome condensation", "activation of eukaryotic chromosome condensation", "activation of nuclear chromosome condensation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905821" ; a owl:Class ; rdfs:label "positive regulation of chromosome condensation" ; rdfs:subClassOf obo:GO_0060623, obo:GO_2001252, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030261 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030261 ] ) ] . obo:GO_1905879 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of oogenesis." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-31T09:31:05Z" ; oboInOwl:hasExactSynonym "regulation of ovum development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905879" ; a owl:Class ; rdfs:label "regulation of oogenesis" ; rdfs:subClassOf obo:GO_0051239, obo:GO_0060284, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:GO_1905880 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-31T09:31:15Z" ; oboInOwl:hasExactSynonym "down regulation of oogenesis", "down regulation of ovum development", "down-regulation of oogenesis", "down-regulation of ovum development", "downregulation of oogenesis", "downregulation of ovum development", "negative regulation of ovum development" ; oboInOwl:hasNarrowSynonym "inhibition of oogenesis", "inhibition of ovum development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905880" ; a owl:Class ; rdfs:label "negative regulation of oogenesis" ; rdfs:subClassOf obo:GO_0010721, obo:GO_0051241, obo:GO_1905879, obo:GO_2000242, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:GO_1905881 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of oogenesis." ; oboInOwl:created_by "hbye" ; oboInOwl:creation_date "2017-01-31T09:31:23Z" ; oboInOwl:hasExactSynonym "positive regulation of ovum development", "up regulation of oogenesis", "up regulation of ovum development", "up-regulation of oogenesis", "up-regulation of ovum development", "upregulation of oogenesis", "upregulation of ovum development" ; oboInOwl:hasNarrowSynonym "activation of oogenesis", "activation of ovum development" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905881" ; a owl:Class ; rdfs:label "positive regulation of oogenesis" ; rdfs:subClassOf obo:GO_0010720, obo:GO_0051240, obo:GO_1905879, obo:GO_2000243, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048477 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:GO_1905902 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mesoderm formation." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2017-02-03T12:28:20Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905902" ; a owl:Class ; rdfs:label "regulation of mesoderm formation" ; rdfs:subClassOf obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001707 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001707 ] ) ] . obo:GO_1905903 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2017-02-03T12:28:29Z" ; oboInOwl:hasExactSynonym "down regulation of mesoderm formation", "down-regulation of mesoderm formation", "downregulation of mesoderm formation" ; oboInOwl:hasNarrowSynonym "inhibition of mesoderm formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905903" ; a owl:Class ; rdfs:label "negative regulation of mesoderm formation" ; rdfs:subClassOf obo:GO_1905902, obo:GO_2000381, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001707 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001707 ] ) ] . obo:GO_1905904 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mesoderm formation." ; oboInOwl:created_by "rph" ; oboInOwl:creation_date "2017-02-03T12:28:38Z" ; oboInOwl:hasExactSynonym "up regulation of mesoderm formation", "up-regulation of mesoderm formation", "upregulation of mesoderm formation" ; oboInOwl:hasNarrowSynonym "activation of mesoderm formation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905904" ; a owl:Class ; rdfs:label "positive regulation of mesoderm formation" ; rdfs:subClassOf obo:GO_1905902, obo:GO_2000382, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001707 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001707 ] ) ] . obo:GO_1905951 obo:IAO_0000115 "Any DNA recombination that takes place in mitochondrion." ; oboInOwl:created_by "vw" ; oboInOwl:creation_date "2017-02-19T10:48:17Z" ; oboInOwl:hasExactSynonym "DNA recombination in mitochondria" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905951" ; a owl:Class ; rdfs:label "mitochondrion DNA recombination" ; rdfs:subClassOf obo:GO_0006310, obo:GO_0032042 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0006310 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] . obo:GO_1905952 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of lipid localization." ; oboInOwl:created_by "rz" ; oboInOwl:creation_date "2017-02-21T12:12:22Z" ; oboInOwl:hasExactSynonym "regulation of lipid localisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905952" ; a owl:Class ; rdfs:label "regulation of lipid localization" ; rdfs:subClassOf obo:GO_0032879, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010876 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0010876 ] ) ] . obo:GO_1905953 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." ; oboInOwl:created_by "rz" ; oboInOwl:creation_date "2017-02-21T12:12:41Z" ; oboInOwl:hasExactSynonym "down regulation of lipid localisation", "down regulation of lipid localization", "down-regulation of lipid localisation", "down-regulation of lipid localization", "downregulation of lipid localisation", "downregulation of lipid localization", "negative regulation of lipid localisation" ; oboInOwl:hasNarrowSynonym "inhibition of lipid localisation", "inhibition of lipid localization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905953" ; a owl:Class ; rdfs:label "negative regulation of lipid localization" ; rdfs:subClassOf obo:GO_0048519, obo:GO_1905952, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010876 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0010876 ] ) ] . obo:GO_1905954 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of lipid localization." ; oboInOwl:created_by "rz" ; oboInOwl:creation_date "2017-02-21T12:12:49Z" ; oboInOwl:hasExactSynonym "positive regulation of lipid localisation", "up regulation of lipid localisation", "up regulation of lipid localization", "up-regulation of lipid localisation", "up-regulation of lipid localization", "upregulation of lipid localisation", "upregulation of lipid localization" ; oboInOwl:hasNarrowSynonym "activation of lipid localisation", "activation of lipid localization" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1905954" ; a owl:Class ; rdfs:label "positive regulation of lipid localization" ; rdfs:subClassOf obo:GO_0048518, obo:GO_1905952, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010876 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0010876 ] ) ] . obo:GO_1990234 obo:IAO_0000115 "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." ; oboInOwl:created_by "bhm" ; oboInOwl:creation_date "2013-11-12T13:20:12Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:1990234" ; a owl:Class ; rdfs:label "transferase complex" ; rdfs:subClassOf obo:GO_1902494 . obo:GO_1990266 obo:IAO_0000115 "The movement of a neutrophil within or between different tissues and organs of the body." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2014-01-10T00:17:47Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1990266" ; a owl:Class ; rdfs:label "neutrophil migration" ; rdfs:subClassOf obo:GO_0097530 . obo:GO_1990770 obo:IAO_0000115 "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." ; oboInOwl:created_by "sl" ; oboInOwl:creation_date "2015-06-11T18:02:33Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:1990770" ; a owl:Class ; rdfs:label "small intestine smooth muscle contraction" ; rdfs:subClassOf obo:GO_0006939, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0014827 ] . obo:GO_1990777 obo:IAO_0000115 "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2015-06-18T08:42:53Z" ; oboInOwl:hasOBONamespace "cellular_component" ; oboInOwl:id "GO:1990777" ; a owl:Class ; rdfs:label "lipoprotein particle" ; rdfs:subClassOf obo:GO_0032994 . obo:GO_2000026 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of multicellular organismal development." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-08-05T11:25:59Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000026" ; a owl:Class ; rdfs:label "regulation of multicellular organismal development" ; rdfs:subClassOf obo:GO_0050793, obo:GO_0051239, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007275 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007275 ] ) ] . obo:GO_2000027 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-08-05T11:26:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of histogenesis and organogenesis" ; oboInOwl:id "GO:2000027" ; a owl:Class ; rdfs:label "regulation of animal organ morphogenesis" ; rdfs:subClassOf obo:GO_0022603, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0009887 ] ) ] . obo:GO_2000035 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of stem cell division." ; oboInOwl:created_by "tb" ; oboInOwl:creation_date "2010-08-05T11:34:53Z" ; oboInOwl:hasExactSynonym "regulation of stem cell renewal" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000035" ; a owl:Class ; rdfs:label "regulation of stem cell division" ; rdfs:subClassOf obo:GO_0051302, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0017145 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0017145 ] ) ] . obo:GO_2000106 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-15T01:42:05Z" ; oboInOwl:hasNarrowSynonym "regulation of leukocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000106" ; a owl:Class ; rdfs:label "regulation of leukocyte apoptotic process" ; rdfs:subClassOf obo:GO_0042981, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0071887 ] ) ] . obo:GO_2000107 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-15T01:42:09Z" ; oboInOwl:hasNarrowSynonym "negative regulation of leukocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000107" ; a owl:Class ; rdfs:label "negative regulation of leukocyte apoptotic process" ; rdfs:subClassOf obo:GO_0043066, obo:GO_2000106, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0071887 ] ) ] . obo:GO_2000108 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-09-15T01:42:12Z" ; oboInOwl:hasNarrowSynonym "positive regulation of leukocyte apoptosis" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000108" ; a owl:Class ; rdfs:label "positive regulation of leukocyte apoptotic process" ; rdfs:subClassOf obo:GO_0043065, obo:GO_2000106, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071887 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0071887 ] ) ] . obo:GO_2000145 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of cell motility." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-01T09:41:21Z" ; oboInOwl:hasExactSynonym "regulation of cell locomotion", "regulation of movement of a cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of cell movement" ; oboInOwl:id "GO:2000145" ; a owl:Class ; rdfs:label "regulation of cell motility" ; rdfs:subClassOf obo:GO_0040012, obo:GO_0050794, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048870 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:GO_2000146 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-01T09:41:26Z" ; oboInOwl:hasExactSynonym "negative regulation of cell locomotion", "negative regulation of movement of a cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of cell movement" ; oboInOwl:id "GO:2000146" ; a owl:Class ; rdfs:label "negative regulation of cell motility" ; rdfs:subClassOf obo:GO_0040013, obo:GO_0048523, obo:GO_2000145, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048870 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:GO_2000147 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cell motility." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-01T09:41:30Z" ; oboInOwl:hasExactSynonym "positive regulation of cell locomotion", "positive regulation of movement of a cell" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of cell movement" ; oboInOwl:id "GO:2000147" ; a owl:Class ; rdfs:label "positive regulation of cell motility" ; rdfs:subClassOf obo:GO_0040017, obo:GO_0048522, obo:GO_2000145, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048870 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0048870 ] ) ] . obo:GO_2000155 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-10-04T12:41:05Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of ciliary cell motility" ; oboInOwl:id "GO:2000155" ; a owl:Class ; rdfs:label "positive regulation of cilium-dependent cell motility" ; rdfs:subClassOf obo:GO_1902019, obo:GO_2000147, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060285 ] ) ] . obo:GO_2000181 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." ; oboInOwl:created_by "dph" ; oboInOwl:creation_date "2010-10-13T12:46:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000181" ; a owl:Class ; rdfs:label "negative regulation of blood vessel morphogenesis" ; rdfs:subClassOf obo:GO_0022603, obo:GO_1901343, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048514 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0048514 ] ) ] . obo:GO_2000214 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of proline metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-03T02:45:20Z" ; oboInOwl:hasExactSynonym "regulation of proline metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000214" ; a owl:Class ; rdfs:label "regulation of proline metabolic process" ; rdfs:subClassOf obo:GO_0000820, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006560 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006560 ] ) ] . obo:GO_2000215 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-03T02:45:24Z" ; oboInOwl:hasExactSynonym "negative regulation of proline metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000215" ; a owl:Class ; rdfs:label "negative regulation of proline metabolic process" ; rdfs:subClassOf obo:GO_0045763, obo:GO_2000214, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006560 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006560 ] ) ] . obo:GO_2000216 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of proline metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-03T02:45:27Z" ; oboInOwl:hasExactSynonym "positive regulation of proline metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000216" ; a owl:Class ; rdfs:label "positive regulation of proline metabolic process" ; rdfs:subClassOf obo:GO_0045764, obo:GO_2000214, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006560 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006560 ] ) ] . obo:GO_2000241 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of reproductive process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-10T02:44:02Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000241" ; a owl:Class ; rdfs:label "regulation of reproductive process" ; rdfs:subClassOf obo:GO_0050789, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0022414 ] ) ] . obo:GO_2000242 obo:IAO_0000115 "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-10T02:44:05Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000242" ; a owl:Class ; rdfs:label "negative regulation of reproductive process" ; rdfs:subClassOf obo:GO_0048519, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0022414 ] ) ] . obo:GO_2000243 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of reproductive process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-10T02:44:08Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000243" ; a owl:Class ; rdfs:label "positive regulation of reproductive process" ; rdfs:subClassOf obo:GO_0048518, obo:GO_2000241, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0022414 ] ) ] . obo:GO_2000252 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2010-11-18T11:24:14Z" ; oboInOwl:hasExactSynonym "negative regulation of behavioral response to food", "negative regulation of behavioural response to food", "negative regulation of feeding behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of drinking", "negative regulation of eating" ; oboInOwl:id "GO:2000252" ; a owl:Class ; rdfs:label "negative regulation of feeding behavior" ; rdfs:subClassOf obo:GO_0048521, obo:GO_0060259, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007631 ] ) ] . obo:GO_2000253 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of feeding behavior." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2010-11-18T11:24:18Z" ; oboInOwl:hasExactSynonym "positive regulation of behavioral response to food", "positive regulation of behavioural response to food", "positive regulation of feeding behaviour" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of drinking", "positive regulation of eating" ; oboInOwl:id "GO:2000253" ; a owl:Class ; rdfs:label "positive regulation of feeding behavior" ; rdfs:subClassOf obo:GO_0048520, obo:GO_0060259, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007631 ] ) ] . obo:GO_2000257 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of protein activation cascade." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:33:46Z" ; oboInOwl:hasExactSynonym "regulation of protein activation pathway", "regulation of protein activitory cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000257" ; a owl:Class ; rdfs:label "regulation of protein activation cascade" ; rdfs:subClassOf obo:GO_1903317, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072376 ] ) ] . obo:GO_2000258 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:33:51Z" ; oboInOwl:hasExactSynonym "negative regulation of protein activation pathway", "negative regulation of protein activitory cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000258" ; a owl:Class ; rdfs:label "negative regulation of protein activation cascade" ; rdfs:subClassOf obo:GO_1903318, obo:GO_2000257, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072376 ] ) ] . obo:GO_2000259 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of protein activation cascade." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:33:55Z" ; oboInOwl:hasExactSynonym "positive regulation of protein activation pathway", "positive regulation of protein activitory cascade" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000259" ; a owl:Class ; rdfs:label "positive regulation of protein activation cascade" ; rdfs:subClassOf obo:GO_1903319, obo:GO_2000257, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072376 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072376 ] ) ] . obo:GO_2000260 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:42:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000260" ; a owl:Class ; rdfs:label "regulation of blood coagulation, common pathway" ; rdfs:subClassOf obo:GO_0030193, obo:GO_2000257, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072377 ] ) ] . obo:GO_2000261 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:42:44Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000261" ; a owl:Class ; rdfs:label "negative regulation of blood coagulation, common pathway" ; rdfs:subClassOf obo:GO_0030195, obo:GO_2000258, obo:GO_2000260, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072377 ] ) ] . obo:GO_2000262 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:42:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000262" ; a owl:Class ; rdfs:label "positive regulation of blood coagulation, common pathway" ; rdfs:subClassOf obo:GO_0030194, obo:GO_2000259, obo:GO_2000260, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072377 ] ) ] . obo:GO_2000263 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:44:35Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000263" ; a owl:Class ; rdfs:label "regulation of blood coagulation, extrinsic pathway" ; rdfs:subClassOf obo:GO_0030193, obo:GO_2000257, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007598 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007598 ] ) ] . obo:GO_2000264 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:44:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000264" ; a owl:Class ; rdfs:label "negative regulation of blood coagulation, extrinsic pathway" ; rdfs:subClassOf obo:GO_0030195, obo:GO_2000258, obo:GO_2000263, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007598 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007598 ] ) ] . obo:GO_2000265 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:44:46Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000265" ; a owl:Class ; rdfs:label "positive regulation of blood coagulation, extrinsic pathway" ; rdfs:subClassOf obo:GO_0030194, obo:GO_2000259, obo:GO_2000263, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007598 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007598 ] ) ] . obo:GO_2000266 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:45:40Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000266" ; a owl:Class ; rdfs:label "regulation of blood coagulation, intrinsic pathway" ; rdfs:subClassOf obo:GO_0030193, obo:GO_2000257, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007597 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007597 ] ) ] . obo:GO_2000267 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:45:46Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000267" ; a owl:Class ; rdfs:label "negative regulation of blood coagulation, intrinsic pathway" ; rdfs:subClassOf obo:GO_0030195, obo:GO_2000258, obo:GO_2000266, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007597 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007597 ] ) ] . obo:GO_2000268 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2010-11-23T11:45:51Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000268" ; a owl:Class ; rdfs:label "positive regulation of blood coagulation, intrinsic pathway" ; rdfs:subClassOf obo:GO_0030194, obo:GO_2000259, obo:GO_2000266, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007597 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007597 ] ) ] . obo:GO_2000272 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-02T09:28:47Z" ; oboInOwl:hasBroadSynonym "negative regulation of receptor activity" ; oboInOwl:hasExactSynonym "negative regulation of signalling receptor activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000272" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "negative regulation of signaling receptor activity" ; rdfs:subClassOf obo:GO_0010469, obo:GO_0044092, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0038023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0038023 ] ) ] . obo:GO_2000273 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-02T09:28:50Z" ; oboInOwl:hasExactSynonym "positive regulation of signalling receptor activity" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000273" ; oboInOwl:inSubset go:gocheck_do_not_annotate ; a owl:Class ; rdfs:label "positive regulation of signaling receptor activity" ; rdfs:subClassOf obo:GO_0010469, obo:GO_0044093, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0038023 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0038023 ] ) ] . obo:GO_2000292 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of defecation." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-21T09:23:08Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000292" ; a owl:Class ; rdfs:label "regulation of defecation" ; rdfs:subClassOf obo:GO_0044058, obo:GO_0044062, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0030421 ] ) ] . obo:GO_2000293 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-21T09:23:13Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000293" ; a owl:Class ; rdfs:label "negative regulation of defecation" ; rdfs:subClassOf obo:GO_0051048, obo:GO_0060457, obo:GO_2000292, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0030421 ] ) ] . obo:GO_2000294 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of defecation." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2010-12-21T09:23:16Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000294" ; a owl:Class ; rdfs:label "positive regulation of defecation" ; rdfs:subClassOf obo:GO_0051047, obo:GO_0060456, obo:GO_2000292, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0030421 ] ) ] . obo:GO_2000377 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-02-11T02:06:36Z" ; oboInOwl:hasExactSynonym "regulation of ROS metabolic process", "regulation of reactive oxygen species metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000377" ; a owl:Class ; rdfs:label "regulation of reactive oxygen species metabolic process" ; rdfs:subClassOf obo:GO_0031323, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0072593 ] ) ] . obo:GO_2000378 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-02-11T02:06:49Z" ; oboInOwl:hasExactSynonym "negative regulation of ROS metabolic process", "negative regulation of reactive oxygen species metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000378" ; a owl:Class ; rdfs:label "negative regulation of reactive oxygen species metabolic process" ; rdfs:subClassOf obo:GO_0031324, obo:GO_2000377, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0072593 ] ) ] . obo:GO_2000379 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." ; oboInOwl:created_by "mah" ; oboInOwl:creation_date "2011-02-11T02:06:57Z" ; oboInOwl:hasExactSynonym "positive regulation of ROS metabolic process", "positive regulation of reactive oxygen species metabolism" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000379" ; a owl:Class ; rdfs:label "positive regulation of reactive oxygen species metabolic process" ; rdfs:subClassOf obo:GO_0031325, obo:GO_2000377, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072593 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0072593 ] ) ] . obo:GO_2000380 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mesoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:09:46Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000380" ; a owl:Class ; rdfs:label "regulation of mesoderm development" ; rdfs:subClassOf obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007498 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007498 ] ) ] . obo:GO_2000381 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:10:02Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000381" ; a owl:Class ; rdfs:label "negative regulation of mesoderm development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_2000380, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007498 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007498 ] ) ] . obo:GO_2000382 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mesoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:10:12Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000382" ; a owl:Class ; rdfs:label "positive regulation of mesoderm development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_2000380, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007498 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007498 ] ) ] . obo:GO_2000383 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of ectoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:17:10Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000383" ; a owl:Class ; rdfs:label "regulation of ectoderm development" ; rdfs:subClassOf obo:GO_0050793, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0007398 ] ) ] . obo:GO_2000384 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:17:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000384" ; a owl:Class ; rdfs:label "negative regulation of ectoderm development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_2000383, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007398 ] ) ] . obo:GO_2000385 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of ectoderm development." ; oboInOwl:created_by "vk" ; oboInOwl:creation_date "2011-02-15T03:17:39Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000385" ; a owl:Class ; rdfs:label "positive regulation of ectoderm development" ; rdfs:subClassOf obo:GO_0051094, obo:GO_2000383, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007398 ] ) ] . obo:GO_2000463 obo:IAO_0000115 "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." ; oboInOwl:created_by "rl" ; oboInOwl:creation_date "2011-03-04T02:43:32Z" ; oboInOwl:hasExactSynonym "positive regulation of excitatory post-synaptic membrane potential" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of EPSP" ; oboInOwl:id "GO:2000463" ; a owl:Class ; rdfs:label "positive regulation of excitatory postsynaptic potential" ; rdfs:subClassOf obo:GO_0009967, obo:GO_0098815, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0050789 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060079 ] ) ] . obo:GO_2000542 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-04-01T04:10:08Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000542" ; a owl:Class ; rdfs:label "negative regulation of gastrulation" ; rdfs:subClassOf obo:GO_0010470, obo:GO_0045992, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0007369 ] ) ] . obo:GO_2000543 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gastrulation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-04-01T04:10:15Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000543" ; a owl:Class ; rdfs:label "positive regulation of gastrulation" ; rdfs:subClassOf obo:GO_0010470, obo:GO_0040019, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007369 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0007369 ] ) ] . obo:GO_2000609 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of thyroid hormone generation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-04-18T10:12:14Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000609" ; a owl:Class ; rdfs:label "regulation of thyroid hormone generation" ; rdfs:subClassOf obo:GO_0031323, obo:GO_0032350, obo:GO_0051171, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0006590 ] ) ] . obo:GO_2000610 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-04-18T10:12:19Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000610" ; a owl:Class ; rdfs:label "negative regulation of thyroid hormone generation" ; rdfs:subClassOf obo:GO_0031324, obo:GO_0032351, obo:GO_0051172, obo:GO_2000609, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0006590 ] ) ] . obo:GO_2000611 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-04-18T10:12:22Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000611" ; a owl:Class ; rdfs:label "positive regulation of thyroid hormone generation" ; rdfs:subClassOf obo:GO_0031325, obo:GO_0032352, obo:GO_0051173, obo:GO_2000609, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006590 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0006590 ] ) ] . obo:GO_2000790 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-06-24T01:53:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000790" ; a owl:Class ; rdfs:label "regulation of mesenchymal cell proliferation involved in lung development" ; rdfs:subClassOf obo:GO_0010464, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060916 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0060916 ] ) ] . obo:GO_2000791 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-06-24T01:53:53Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000791" ; a owl:Class ; rdfs:label "negative regulation of mesenchymal cell proliferation involved in lung development" ; rdfs:subClassOf obo:GO_0051093, obo:GO_0051241, obo:GO_0072201, obo:GO_2000790, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060916 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0060916 ] ) ] . obo:GO_2000792 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." ; oboInOwl:created_by "pr" ; oboInOwl:creation_date "2011-06-24T01:53:56Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000792" ; a owl:Class ; rdfs:label "positive regulation of mesenchymal cell proliferation involved in lung development" ; rdfs:subClassOf obo:GO_0002053, obo:GO_0051094, obo:GO_0051240, obo:GO_2000790, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060916 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0060916 ] ) ] . obo:GO_2000828 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:37:53Z" ; oboInOwl:hasExactSynonym "regulation of PTH secretion", "regulation of parathormone secretion", "regulation of parathyrin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000828" ; a owl:Class ; rdfs:label "regulation of parathyroid hormone secretion" ; rdfs:subClassOf obo:GO_0044060, obo:GO_0046883, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035898 ] ) ] . obo:GO_2000829 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:37:57Z" ; oboInOwl:hasExactSynonym "negative regulation of PTH secretion", "negative regulation of parathormone secretion", "negative regulation of parathyrin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000829" ; a owl:Class ; rdfs:label "negative regulation of parathyroid hormone secretion" ; rdfs:subClassOf obo:GO_0046888, obo:GO_0051241, obo:GO_2000828, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035898 ] ) ] . obo:GO_2000830 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:38:00Z" ; oboInOwl:hasExactSynonym "positive regulation of PTH secretion", "positive regulation of parathormone secretion", "positive regulation of parathyrin secretion" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000830" ; a owl:Class ; rdfs:label "positive regulation of parathyroid hormone secretion" ; rdfs:subClassOf obo:GO_0046887, obo:GO_0051240, obo:GO_2000828, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035898 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035898 ] ) ] . obo:GO_2000831 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of steroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:38:46Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000831" ; a owl:Class ; rdfs:label "regulation of steroid hormone secretion" ; rdfs:subClassOf obo:GO_0032368, obo:GO_0044060, obo:GO_0046883, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035929 ] ) ] . obo:GO_2000832 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:38:50Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000832" ; a owl:Class ; rdfs:label "negative regulation of steroid hormone secretion" ; rdfs:subClassOf obo:GO_0032369, obo:GO_0046888, obo:GO_0051241, obo:GO_2000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035929 ] ) ] . obo:GO_2000833 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:38:51Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000833" ; a owl:Class ; rdfs:label "positive regulation of steroid hormone secretion" ; rdfs:subClassOf obo:GO_0032370, obo:GO_0046887, obo:GO_0051240, obo:GO_2000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035929 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035929 ] ) ] . obo:GO_2000834 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of androgen secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:39:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000834" ; a owl:Class ; rdfs:label "regulation of androgen secretion" ; rdfs:subClassOf obo:GO_2000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035935 ] ) ] . obo:GO_2000835 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:39:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000835" ; a owl:Class ; rdfs:label "negative regulation of androgen secretion" ; rdfs:subClassOf obo:GO_2000832, obo:GO_2000834, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035935 ] ) ] . obo:GO_2000836 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of androgen secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:39:51Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000836" ; a owl:Class ; rdfs:label "positive regulation of androgen secretion" ; rdfs:subClassOf obo:GO_2000833, obo:GO_2000834, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035935 ] ) ] . obo:GO_2000843 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of testosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:42:29Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000843" ; a owl:Class ; rdfs:label "regulation of testosterone secretion" ; rdfs:subClassOf obo:GO_0032368, obo:GO_0046883, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035936 ] ) ] . obo:GO_2000844 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:42:33Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000844" ; a owl:Class ; rdfs:label "negative regulation of testosterone secretion" ; rdfs:subClassOf obo:GO_0032369, obo:GO_0046888, obo:GO_2000843, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035936 ] ) ] . obo:GO_2000845 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of testosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:42:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000845" ; a owl:Class ; rdfs:label "positive regulation of testosterone secretion" ; rdfs:subClassOf obo:GO_0032370, obo:GO_0046887, obo:GO_2000843, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035936 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035936 ] ) ] . obo:GO_2000846 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:43:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of corticosteroid secretion" ; oboInOwl:id "GO:2000846" ; a owl:Class ; rdfs:label "regulation of corticosteroid hormone secretion" ; rdfs:subClassOf obo:GO_2000831, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035930 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035930 ] ) ] . obo:GO_2000847 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:43:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of corticosteroid secretion" ; oboInOwl:id "GO:2000847" ; a owl:Class ; rdfs:label "negative regulation of corticosteroid hormone secretion" ; rdfs:subClassOf obo:GO_2000832, obo:GO_2000846, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035930 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035930 ] ) ] . obo:GO_2000848 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:43:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of corticosteroid secretion" ; oboInOwl:id "GO:2000848" ; a owl:Class ; rdfs:label "positive regulation of corticosteroid hormone secretion" ; rdfs:subClassOf obo:GO_2000833, obo:GO_2000846, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035930 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035930 ] ) ] . obo:GO_2000855 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:46:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000855" ; a owl:Class ; rdfs:label "regulation of mineralocorticoid secretion" ; rdfs:subClassOf obo:GO_2000846, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035931 ] ) ] . obo:GO_2000856 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:46:42Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000856" ; a owl:Class ; rdfs:label "negative regulation of mineralocorticoid secretion" ; rdfs:subClassOf obo:GO_2000847, obo:GO_2000855, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035931 ] ) ] . obo:GO_2000857 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:46:45Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000857" ; a owl:Class ; rdfs:label "positive regulation of mineralocorticoid secretion" ; rdfs:subClassOf obo:GO_2000848, obo:GO_2000855, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035931 ] ) ] . obo:GO_2000858 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of aldosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:47:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000858" ; a owl:Class ; rdfs:label "regulation of aldosterone secretion" ; rdfs:subClassOf obo:GO_2000855, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0035932 ] ) ] . obo:GO_2000859 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:47:31Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000859" ; a owl:Class ; rdfs:label "negative regulation of aldosterone secretion" ; rdfs:subClassOf obo:GO_2000856, obo:GO_2000858, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0035932 ] ) ] . obo:GO_2000860 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." ; oboInOwl:created_by "bf" ; oboInOwl:creation_date "2011-07-26T08:47:34Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2000860" ; a owl:Class ; rdfs:label "positive regulation of aldosterone secretion" ; rdfs:subClassOf obo:GO_2000857, obo:GO_2000858, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035932 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0035932 ] ) ] . obo:GO_2001151 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of renal water transport." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-10-24T11:37:51Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001151" ; a owl:Class ; rdfs:label "regulation of renal water transport" ; rdfs:subClassOf obo:GO_0050878, obo:GO_0051049, obo:GO_0098801, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0003097 ] ) ] . obo:GO_2001152 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-10-24T11:37:57Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001152" ; a owl:Class ; rdfs:label "negative regulation of renal water transport" ; rdfs:subClassOf obo:GO_0051051, obo:GO_0051241, obo:GO_2001151, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0003097 ] ) ] . obo:GO_2001153 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of renal water transport." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-10-24T11:38:01Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001153" ; a owl:Class ; rdfs:label "positive regulation of renal water transport" ; rdfs:subClassOf obo:GO_0051050, obo:GO_0051240, obo:GO_2001151, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0003097 ] ) ] . obo:GO_2001191 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-03T04:28:38Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of gamma-delta T cell activation during immune response", "regulation of gamma-delta T lymphocyte activation during immune response", "regulation of gamma-delta T-cell activation during immune response", "regulation of gamma-delta T-lymphocyte activation during immune response" ; oboInOwl:id "GO:2001191" ; a owl:Class ; rdfs:label "regulation of gamma-delta T cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002697, obo:GO_0046643, obo:GO_0050776, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0002290 ] ) ] . obo:GO_2001192 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-03T04:28:44Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of gamma-delta T cell activation during immune response", "negative regulation of gamma-delta T lymphocyte activation during immune response", "negative regulation of gamma-delta T-cell activation during immune response", "negative regulation of gamma-delta T-lymphocyte activation during immune response" ; oboInOwl:id "GO:2001192" ; a owl:Class ; rdfs:label "negative regulation of gamma-delta T cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002698, obo:GO_0046644, obo:GO_0050777, obo:GO_2001191, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0002290 ] ) ] . obo:GO_2001193 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-03T04:28:48Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of gamma-delta T cell activation during immune response", "positive regulation of gamma-delta T lymphocyte activation during immune response", "positive regulation of gamma-delta T-cell activation during immune response", "positive regulation of gamma-delta T-lymphocyte activation during immune response" ; oboInOwl:id "GO:2001193" ; a owl:Class ; rdfs:label "positive regulation of gamma-delta T cell activation involved in immune response" ; rdfs:subClassOf obo:GO_0002699, obo:GO_0046645, obo:GO_0050778, obo:GO_2001191, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0002290 ] ) ] . obo:GO_2001198 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-04T02:01:27Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001198" ; a owl:Class ; rdfs:label "regulation of dendritic cell differentiation" ; rdfs:subClassOf obo:GO_1902105, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0097028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0097028 ] ) ] . obo:GO_2001199 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-04T02:01:33Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001199" ; a owl:Class ; rdfs:label "negative regulation of dendritic cell differentiation" ; rdfs:subClassOf obo:GO_1902106, obo:GO_2001198, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0097028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0097028 ] ) ] . obo:GO_2001200 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-11-04T02:01:36Z" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:id "GO:2001200" ; a owl:Class ; rdfs:label "positive regulation of dendritic cell differentiation" ; rdfs:subClassOf obo:GO_1902107, obo:GO_2001198, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0097028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0097028 ] ) ] . obo:GO_2001222 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of neuron migration." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2011-11-17T10:01:38Z" ; oboInOwl:hasExactSynonym "regulation of neuron chemotaxis", "regulation of neuronal migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "regulation of neuron guidance" ; oboInOwl:id "GO:2001222" ; a owl:Class ; rdfs:label "regulation of neuron migration" ; rdfs:subClassOf obo:GO_0030334, [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001764 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:GO_0001764 ] ) ] . obo:GO_2001223 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2011-11-17T10:01:45Z" ; oboInOwl:hasExactSynonym "negative regulation of neuron chemotaxis", "negative regulation of neuronal migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of neuron guidance" ; oboInOwl:id "GO:2001223" ; a owl:Class ; rdfs:label "negative regulation of neuron migration" ; rdfs:subClassOf obo:GO_0030336, obo:GO_2001222, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001764 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0001764 ] ) ] . obo:GO_2001224 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of neuron migration." ; oboInOwl:created_by "kmv" ; oboInOwl:creation_date "2011-11-17T10:01:49Z" ; oboInOwl:hasExactSynonym "positive regulation of neuron chemotaxis", "positive regulation of neuronal migration" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of neuron guidance" ; oboInOwl:id "GO:2001224" ; a owl:Class ; rdfs:label "positive regulation of neuron migration" ; rdfs:subClassOf obo:GO_0030335, obo:GO_2001222, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001764 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0001764 ] ) ] . obo:GO_2001251 obo:IAO_0000115 "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-12-02T02:01:20Z" ; oboInOwl:hasExactSynonym "negative regulation of chromosome organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "negative regulation of chromosome organization and biogenesis", "negative regulation of maintenance of genome integrity", "negative regulation of nuclear genome maintenance" ; oboInOwl:id "GO:2001251" ; a owl:Class ; rdfs:label "negative regulation of chromosome organization" ; rdfs:subClassOf obo:GO_0010639, obo:GO_0033044, [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002212 ; owl:someValuesFrom obo:GO_0051276 ] ) ] . obo:GO_2001252 obo:IAO_0000115 "Any process that activates or increases the frequency, rate or extent of chromosome organization." ; oboInOwl:created_by "yaf" ; oboInOwl:creation_date "2011-12-02T02:01:26Z" ; oboInOwl:hasExactSynonym "positive regulation of chromosome organisation" ; oboInOwl:hasOBONamespace "biological_process" ; oboInOwl:hasRelatedSynonym "positive regulation of chromosome organization and biogenesis", "positive regulation of maintenance of genome integrity", "positive regulation of nuclear genome maintenance" ; oboInOwl:id "GO:2001252" ; a owl:Class ; rdfs:label "positive regulation of chromosome organization" ; rdfs:subClassOf obo:GO_0010638, obo:GO_0033044, [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051276 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:GO_0065007 [ a owl:Restriction ; owl:onProperty obo:RO_0002213 ; owl:someValuesFrom obo:GO_0051276 ] ) ] . obo:HP_0000001 oboInOwl:hasDbXref "UMLS:C0444868" ; oboInOwl:id "HP:0000001" ; a owl:Class ; rdfs:comment "Root of all terms in the Human Phenotype Ontology." ; rdfs:label "All" . obo:HP_0000002 obo:IAO_0000115 "Deviation from the norm of height with respect to that which is expected according to age and gender norms." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T02:20:00Z" ; oboInOwl:hasDbXref "UMLS:C4025901" ; oboInOwl:hasExactSynonym "Abnormality of body height" ; oboInOwl:id "HP:0000002" ; a owl:Class ; rdfs:label "Abnormality of body height" ; rdfs:subClassOf obo:HP_0001507 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000003 obo:IAO_0000115 "Multicystic dysplasia of the kidney is characterized by multiple cysts of varying size in the kidney and the absence of a normal pelvicaliceal system. The condition is associated with ureteral or ureteropelvic atresia, and the affected kidney is nonfunctional." ; oboInOwl:hasAlternativeId "HP:0004715" ; oboInOwl:hasDbXref "MSH:D021782", "SNOMEDCT_US:204962002", "SNOMEDCT_US:82525005", "UMLS:C3714581" ; oboInOwl:hasExactSynonym "Multicystic dysplastic kidney", "Multicystic kidneys", "Multicystic renal dysplasia" ; oboInOwl:id "HP:0000003" ; a owl:Class ; rdfs:comment "Multicystic kidney dysplasia is the result of abnormal fetal renal development in which the affected kidney is replaced by multiple cysts and has little or no residual function. The vast majority of multicystic kidneys are unilateral. Multicystic kidney can be diagnosed on prenatal ultrasound." ; rdfs:label "Multicystic kidney dysplasia" ; rdfs:subClassOf obo:HP_0000107 . obo:HP_0000005 obo:IAO_0000115 "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." ; oboInOwl:hasAlternativeId "HP:0001425", "HP:0001453", "HP:0001461", "HP:0010985" ; oboInOwl:hasDbXref "UMLS:C1708511" ; oboInOwl:hasExactSynonym "Inheritance" ; oboInOwl:id "HP:0000005" ; a owl:Class ; rdfs:comment """While there is a close conceptual relationship between allelic requirement and inheritance, they serve different purposes; allelic requirement is necessary for variant annotation pipelines and to determine if a given variant in a specific context is relevant to the phenotype of the patient e.g. a heterozygous variant (in the absence of compound heterozygosity) is relevant for dominant but not for recessive disease; while inheritance is used for describing the mode of inheritance of a phenotype and is particularly applicable in the clinical setting for communicating recurrence risk, to guide family screening, and to guide reproductive advice.""" ; rdfs:label "Mode of inheritance" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0000006 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." ; oboInOwl:hasAlternativeId "HP:0001415", "HP:0001447", "HP:0001448", "HP:0001451", "HP:0001452", "HP:0001455", "HP:0001456", "HP:0001463" ; oboInOwl:hasDbXref "SNOMEDCT_US:263681008", "UMLS:C0443147" ; oboInOwl:hasExactSynonym "Autosomal dominant", "monoallelic_autosomal" ; oboInOwl:hasRelatedSynonym "Autosomal dominant form", "Autosomal dominant type" ; oboInOwl:id "HP:0000006" ; a owl:Class ; rdfs:label "Autosomal dominant inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0000007 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." ; oboInOwl:hasAlternativeId "HP:0001416", "HP:0001526", "HP:0031362" ; oboInOwl:hasDbXref "SNOMEDCT_US:258211005", "UMLS:C0441748", "UMLS:C4020899" ; oboInOwl:hasExactSynonym "Autosomal recessive", "biallelic_autosomal" ; oboInOwl:hasRelatedSynonym "Autosomal recessive form", "Autosomal recessive predisposition" ; oboInOwl:id "HP:0000007" ; a owl:Class ; rdfs:label "Autosomal recessive inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0000008 obo:IAO_0000115 "An abnormality of the female internal genitalia." ; oboInOwl:hasDbXref "UMLS:C4025900" ; oboInOwl:hasExactSynonym "Abnormality of female internal genitalia" ; oboInOwl:id "HP:0000008" ; a owl:Class ; rdfs:label "Abnormal morphology of female internal genitalia" ; rdfs:subClassOf obo:HP_0000812, obo:HP_0010460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000009 obo:IAO_0000115 "Dysfunction of the urinary bladder." ; oboInOwl:hasAlternativeId "HP:0004424", "HP:0008731" ; oboInOwl:hasDbXref "UMLS:C3806583" ; oboInOwl:hasExactSynonym "Poor bladder function" ; oboInOwl:id "HP:0000009" ; a owl:Class ; rdfs:label "Functional abnormality of the bladder" ; rdfs:subClassOf obo:HP_0000014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000010 obo:IAO_0000115 "Repeated infections of the urinary tract." ; oboInOwl:hasAlternativeId "HP:0000094" ; oboInOwl:hasDbXref "SNOMEDCT_US:197927001", "UMLS:C0262655" ; oboInOwl:hasExactSynonym "Frequent urinary tract infections", "Recurrent UTIs", "Repeated bladder infections", "Repeated urinary tract infections", "Urinary tract infections", "Urinary tract infections, recurrent" ; oboInOwl:id "HP:0000010" ; a owl:Class ; rdfs:comment "The urinary tract comprises the kidneys, ureters, a bladder, and a urethra." ; rdfs:label "Recurrent urinary tract infections" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0011277 . obo:HP_0000011 obo:IAO_0000115 "A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention." ; oboInOwl:hasDbXref "MSH:D001750", "SNOMEDCT_US:397732007", "SNOMEDCT_US:398064005", "UMLS:C0005697" ; oboInOwl:hasExactSynonym "Lack of bladder control due to nervous system injury" ; oboInOwl:id "HP:0000011" ; a owl:Class ; rdfs:comment "Neurogenic bladder sphincter dysfunction (NBSD) can develop as a result of a lesion at any level in the nervous system, including the cerebral cortex, spinal cord, or peripheral nervous system. Neurologic conditions in children leading to neurogenic bladder dysfunction are predominantly congenital neural tube defects (including myelomeningocele, lipomeningocele, sacral agenesis, and occult lesions causing tethered cord). Acquired causes such as spinal cord tumors or trauma or sequelae of transverse myelitis are less frequent. Whereas from an etiologic standpoint neurogenic bladder dysfunction is a heterogeneous group, medical management will be similar irrespective of the underlying cause." ; rdfs:label "Neurogenic bladder" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000012 obo:IAO_0000115 "Urge incontinence is the strong, sudden need to urinate." ; oboInOwl:hasDbXref "SNOMEDCT_US:75088002", "UMLS:C0085606", "UMLS:C3544092", "UMLS:C4020898" ; oboInOwl:hasExactSynonym "Overactive bladder", "Urinary urgency" ; oboInOwl:hasRelatedSynonym "Overactive bladder syndrome", "Urgency frequency syndrome" ; oboInOwl:id "HP:0000012" ; a owl:Class ; rdfs:comment "Urinary urgency is the strong, sudden need to urinate and is usually due to bladder spasms or contractions. This symptom is suggestive of, but not necessarily conclusive for urodynamically demonstrable detrusor hyperactivity." ; rdfs:label "Urinary urgency" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000013 obo:IAO_0000115 "Underdevelopment of the uterus." ; oboInOwl:hasAlternativeId "HP:0001154", "HP:0008637" ; oboInOwl:hasDbXref "SNOMEDCT_US:35850006", "UMLS:C0266399" ; oboInOwl:hasExactSynonym "Hypoplastic uterus", "Rudimentary uterus", "Small uterus", "Underdeveloped uterus" ; oboInOwl:id "HP:0000013" ; a owl:Class ; rdfs:label "Hypoplasia of the uterus" ; rdfs:subClassOf obo:HP_0008684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000014 obo:IAO_0000115 "An abnormality of the urinary bladder." ; oboInOwl:hasDbXref "UMLS:C0149632" ; oboInOwl:id "HP:0000014" ; a owl:Class ; rdfs:label "Abnormality of the bladder" ; rdfs:subClassOf obo:HP_0010936 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000015 obo:IAO_0000115 "Diverticulum (sac or pouch) in the wall of the urinary bladder." ; oboInOwl:hasDbXref "MSH:C562406", "SNOMEDCT_US:197866008", "UMLS:C0156273" ; oboInOwl:hasExactSynonym "Bladder diverticula" ; oboInOwl:id "HP:0000015" ; a owl:Class ; rdfs:label "Bladder diverticulum" ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_68 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000016 obo:IAO_0000115 "Inability to completely empty the urinary bladder during the process of urination." ; oboInOwl:hasDbXref "MSH:D016055", "SNOMEDCT_US:130951007", "SNOMEDCT_US:267064002", "SNOMEDCT_US:449491000124101", "UMLS:C0080274" ; oboInOwl:hasExactSynonym "Increased post-void residual urine volume" ; oboInOwl:id "HP:0000016" ; a owl:Class ; rdfs:comment "Urinary retention is the inability of the urinary bladder to empty. The cause may be neurologic or nonneurologic." ; rdfs:label "Urinary retention" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000017 obo:IAO_0000115 "Abnormally increased production of urine during the night leading to an unusually frequent need to urinate." ; oboInOwl:hasDbXref "MSH:D053158", "SNOMEDCT_US:139394000", "UMLS:C0028734" ; oboInOwl:hasExactSynonym "Nycturia" ; oboInOwl:id "HP:0000017" ; a owl:Class ; rdfs:comment "Often occuring as a result of heart insufficiency." ; rdfs:label "Nocturia" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000019 obo:IAO_0000115 "Difficulty in beginning the process of urination." ; oboInOwl:hasDbXref "SNOMEDCT_US:5972002", "UMLS:C0152032" ; oboInOwl:hasExactSynonym "Difficulty with flow" ; oboInOwl:id "HP:0000019" ; a owl:Class ; rdfs:label "Urinary hesitancy" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000020 obo:IAO_0000115 "Loss of the ability to control the urinary bladder leading to involuntary urination." ; oboInOwl:hasAlternativeId "HP:0006942", "HP:0008681" ; oboInOwl:hasDbXref "MSH:D014549", "SNOMEDCT_US:165232002", "UMLS:C0042024" ; oboInOwl:hasExactSynonym "Bladder incontinence", "Loss of bladder control" ; oboInOwl:id "HP:0000020" ; a owl:Class ; rdfs:comment "Urinary incontinence can be defined as the complaint of any involuntary leakage of urine." ; rdfs:label "Urinary incontinence" ; rdfs:subClassOf obo:HP_0000009, obo:HP_0031064 . obo:HP_0000021 obo:IAO_0000115 "Dilatation of the bladder postnatally." ; oboInOwl:hasAlternativeId "HP:0002838" ; oboInOwl:hasDbXref "MSH:C536139", "UMLS:C1855311" ; oboInOwl:id "HP:0000021" ; a owl:Class ; rdfs:label "Megacystis" ; rdfs:subClassOf obo:HP_0010955 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001556 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000022 obo:IAO_0000115 "An abnormality of the male internal genitalia." ; oboInOwl:hasDbXref "UMLS:C4025899" ; oboInOwl:id "HP:0000022" ; a owl:Class ; rdfs:comment "The internal genital structures of the male including the testis, epididymis, vas deferens, seminal vesicle, ejaculatory duct, bulbourethral gland, and the prostate." ; rdfs:label "Abnormal male internal genitalia morphology" ; rdfs:subClassOf obo:HP_0000812, obo:HP_0010461 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000023 obo:IAO_0000115 "Protrusion of the contents of the abdominal cavity through the inguinal canal." ; oboInOwl:hasDbXref "MEDDRA:10022016", "MSH:D006552", "SNOMEDCT_US:396232000", "UMLS:C0019294" ; oboInOwl:id "HP:0000023" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Inguinal hernia appears as a bulge in the groin." ; rdfs:label "Inguinal hernia" ; rdfs:subClassOf obo:HP_0004299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002163 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0006674 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000024 obo:IAO_0000115 "The presence of inflammation of the prostate." ; oboInOwl:hasDbXref "MSH:D011472", "SNOMEDCT_US:9713002", "UMLS:C0033581" ; oboInOwl:hasExactSynonym "Inflammation of the prostate" ; oboInOwl:id "HP:0000024" ; a owl:Class ; rdfs:label "Prostatitis" ; rdfs:subClassOf obo:HP_0008775, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000025 oboInOwl:hasDbXref "UMLS:C4025898" ; oboInOwl:id "HP:0000025" ; a owl:Class ; rdfs:label "Functional abnormality of male internal genitalia" ; rdfs:subClassOf obo:HP_0012874 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000026 obo:IAO_0000115 "Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis." ; oboInOwl:hasAlternativeId "HP:0008649" ; oboInOwl:hasDbXref "MSH:D005058", "SNOMEDCT_US:48723006", "UMLS:C0151721" ; oboInOwl:hasExactSynonym "Decreased function of male gonad" ; oboInOwl:id "HP:0000026" ; a owl:Class ; rdfs:label "Male hypogonadism" ; rdfs:subClassOf obo:HP_0000025, obo:HP_0000135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000027 obo:IAO_0000115 "Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet." ; oboInOwl:hasDbXref "MSH:D053713", "SNOMEDCT_US:425558002", "SNOMEDCT_US:48188009", "UMLS:C0004509" ; oboInOwl:hasExactSynonym "Absent sperm in semen" ; oboInOwl:id "HP:0000027" ; a owl:Class ; rdfs:label "Azoospermia" ; rdfs:subClassOf obo:HP_0008669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000019 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001968 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000028 obo:IAO_0000115 "Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." ; oboInOwl:hasAlternativeId "HP:0000797" ; oboInOwl:hasDbXref "Fyler:4493", "MSH:D003456", "SNOMEDCT_US:204878001", "UMLS:C0010417" ; oboInOwl:hasExactSynonym "Cryptorchism", "Undescended testes", "Undescended testis" ; oboInOwl:id "HP:0000028" ; a owl:Class ; rdfs:comment "The gonad is mobile and can be retracted superiorly by the cremaster muscle reflex stimulated, for instance, by cold or touch. A retracted testis is not cryptorchidism. An abdominal testis cannot be distinguished by physical examination from an (Apparently) absent testis and requires radiological (or, rarely, surgical) procedures for assessment." ; rdfs:label "Cryptorchidism" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000029 obo:IAO_0000115 "Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility." ; oboInOwl:hasDbXref "SNOMEDCT_US:17585008", "UMLS:C0156312" ; oboInOwl:hasExactSynonym "Testicular degeneration" ; oboInOwl:id "HP:0000029" ; a owl:Class ; rdfs:label "Testicular atrophy" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000030 obo:IAO_0000115 "The presence of a gonadoblastoma of the testis." ; oboInOwl:hasDbXref "NCIT:C3754", "UMLS:C1515283" ; oboInOwl:hasRelatedSynonym "Gonadoblastoma, male" ; oboInOwl:id "HP:0000030" ; a owl:Class ; rdfs:label "Testicular gonadoblastoma" ; rdfs:subClassOf obo:HP_0000150, obo:HP_0010788 . obo:HP_0000031 obo:IAO_0000115 "The presence of inflammation of the epididymis." ; oboInOwl:hasDbXref "MSH:D004823", "SNOMEDCT_US:31070006", "UMLS:C0014534" ; oboInOwl:id "HP:0000031" ; a owl:Class ; rdfs:label "Epididymitis" ; rdfs:subClassOf obo:HP_0009714, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000032 obo:IAO_0000115 "An abnormality of male external genitalia." ; oboInOwl:hasDbXref "UMLS:C4025897" ; oboInOwl:id "HP:0000032" ; a owl:Class ; rdfs:label "Abnormality of male external genitalia" ; rdfs:subClassOf obo:HP_0000811, obo:HP_0010461 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000033 obo:IAO_0000115 "Ambiguous genitalia in an individual with XY genetic gender." ; oboInOwl:hasDbXref "UMLS:C4021823" ; oboInOwl:hasExactSynonym "Ambiguous genitalia in males" ; oboInOwl:id "HP:0000033" ; a owl:Class ; rdfs:label "Ambiguous genitalia, male" ; rdfs:subClassOf obo:HP_0000032, obo:HP_0000062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000034 obo:IAO_0000115 "Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis." ; oboInOwl:hasBroadSynonym "Hydrocele" ; oboInOwl:hasDbXref "MSH:D006848", "SNOMEDCT_US:26614003", "SNOMEDCT_US:386152007", "SNOMEDCT_US:55434001", "UMLS:C1720771" ; oboInOwl:hasExactSynonym "Testicular hydrocele" ; oboInOwl:id "HP:0000034" ; a owl:Class ; rdfs:label "Hydrocele testis" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002270 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0006314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000035 obo:IAO_0000115 "An anomaly of the testicle (the male gonad)." ; oboInOwl:hasDbXref "SNOMEDCT_US:55631001", "UMLS:C0266423" ; oboInOwl:hasExactSynonym "Abnormality of the testis", "Anomaly of the testes" ; oboInOwl:id "HP:0000035" ; a owl:Class ; rdfs:label "Abnormal testis morphology" ; rdfs:subClassOf obo:HP_0011961 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000036 obo:IAO_0000115 "Abnormality of the male external sex organ." ; oboInOwl:hasDbXref "UMLS:C4025896" ; oboInOwl:hasExactSynonym "Abnormality of the penis" ; oboInOwl:id "HP:0000036" ; a owl:Class ; rdfs:label "Abnormal penis morphology" ; rdfs:subClassOf obo:HP_0000032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000037 obo:IAO_0000115 "Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In male pseudohermaphroditism, the genotype is male (XY) and the external genitalia are imcompletely virilized, ambiguous, or complete female. If gonads are present, they are testes." ; oboInOwl:hasDbXref "MSH:D058490", "SNOMEDCT_US:111332007", "UMLS:C0238395" ; oboInOwl:id "HP:0000037" ; a owl:Class ; rdfs:label "Male pseudohermaphroditism" ; rdfs:subClassOf obo:HP_0000032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001828 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000039 obo:IAO_0000115 "Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias." ; oboInOwl:hasDbXref "SNOMEDCT_US:406477003", "UMLS:C0563449" ; oboInOwl:id "HP:0000039" ; a owl:Class ; rdfs:comment "Epispadias may be present in a phenotypic male, female, or an individual with ambiguous genitalia. A meatus in a phenotypic male may be positioned either on the glans (glandular or balanic epispadias), the shaft (penile epispadias) or at the attachment of the penis to the abdominal wall (penopubic epispadias). Alternatively, the urethra may be an open groove along the dorsal shaft of the penis, with no readily recognized meatus. Epispadias is a frequent component of Bladder exstrophy, but should be coded separately." ; rdfs:label "Epispadias" ; rdfs:subClassOf obo:HP_0100627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001919 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000040 obo:IAO_0000115 "Penile length more than 2 SD above the mean for age." ; oboInOwl:hasDbXref "SNOMEDCT_US:88673001", "UMLS:C0269011" ; oboInOwl:hasExactSynonym "Enlarged penis", "Long penis" ; oboInOwl:id "HP:0000040" ; a owl:Class ; rdfs:comment "Penile length is the distance between the midline attachment of the gently stretched, flaccid penis above the pubic symphysis and tip of the glans." ; rdfs:label "Long penis" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000041 obo:IAO_0000115 "Ventral, lateral, or ventrolateral bowing of the shaft and glans penis of more than 30 degrees." ; oboInOwl:hasDbXref "SNOMEDCT_US:4287008", "UMLS:C0221182" ; oboInOwl:id "HP:0000041" ; a owl:Class ; rdfs:comment "The degree of variation of penis curvature is a continuum, but traditionally 30 degrees is considered the threshold for surgical intervention on chordee. Bowing usually becomes more obvious in an erect penis, but is frequently also palpable when stretching a flaccid penis. Chordee can be congenital or acquired; if the former, it can be associated with Webbed Penis or Hypospadias, which should be coded separately." ; rdfs:label "Chordee" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0000042 obo:IAO_0000115 "Lack of external genitalia in a male or female individual." ; oboInOwl:hasDbXref "UMLS:C1848869" ; oboInOwl:hasExactSynonym "Absent external genitalia" ; oboInOwl:id "HP:0000042" ; a owl:Class ; rdfs:label "Absent external genitalia" ; rdfs:subClassOf obo:HP_0000811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004176 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000044 obo:IAO_0000115 "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." ; oboInOwl:hasAlternativeId "HP:0003335", "HP:0008224" ; oboInOwl:hasDbXref "MSH:D007006", "SNOMEDCT_US:33927004", "UMLS:C0271623", "UMLS:C3489396" ; oboInOwl:hasExactSynonym "Hypogonadotrophic hypogonadism", "Low gonadotropins (secondary hypogonadism)" ; oboInOwl:hasRelatedSynonym "Isolated hypogonadotropic hypogonadism" ; oboInOwl:id "HP:0000044" ; a owl:Class ; rdfs:label "Hypogonadotropic hypogonadism" ; rdfs:subClassOf obo:HP_0000135 . obo:HP_0000045 oboInOwl:hasDbXref "UMLS:C4025895" ; oboInOwl:id "HP:0000045" ; a owl:Class ; rdfs:label "Abnormality of the scrotum" ; rdfs:subClassOf obo:HP_0000032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000046 obo:IAO_0000115 "Apparently small scrotum for age." ; oboInOwl:hasAlternativeId "HP:0030276" ; oboInOwl:hasDbXref "SNOMEDCT_US:204912007", "UMLS:C0431659" ; oboInOwl:hasExactSynonym "Hypoplastic scrotum", "Scrotal hypoplasia", "Smaller than typical growth of scrotum", "Underdeveloped scrotum" ; oboInOwl:id "HP:0000046" ; a owl:Class ; rdfs:comment "A small scrotum is often accompanied by Cryptorchidism which should be coded separately. The size of the scrotum is dependent on the ambient temperature: a low temperature may cause the testes to retract, leading to the false impression of a small scrotum." ; rdfs:label "Small scrotum" ; rdfs:subClassOf obo:HP_0000045, obo:HP_0000050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000047 obo:IAO_0000115 "Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum." ; oboInOwl:hasDbXref "Fyler:4504", "SNOMEDCT_US:204888000", "UMLS:C1691215" ; oboInOwl:hasExactSynonym "Hypospadia" ; oboInOwl:id "HP:0000047" ; a owl:Class ; rdfs:label "Hypospadias" ; rdfs:subClassOf obo:HP_0100627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000048 obo:IAO_0000115 "Midline indentation or cleft of the scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:236780002", "UMLS:C0341787" ; oboInOwl:hasExactSynonym "Cleft of scrotum", "Scrotal cleft" ; oboInOwl:id "HP:0000048" ; a owl:Class ; rdfs:comment "A testis may or may not be present in each half of the scrotum." ; rdfs:label "Bifid scrotum" ; rdfs:subClassOf obo:HP_0000045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000049 obo:IAO_0000115 "Superior margin of the scrotum superior to the base of the penis." ; oboInOwl:hasDbXref "UMLS:C1858539" ; oboInOwl:hasExactSynonym "Overriding scrotum", "Scrotum surrounds penis" ; oboInOwl:id "HP:0000049" ; a owl:Class ; rdfs:comment "A congenital overriding scrotum may disappear with growth and development, especially during puberty. If the entire scrotum is located superior to the penis, the term Penoscrotal transposition is used instead." ; rdfs:label "Shawl scrotum" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0000050 obo:IAO_0000115 "Underdevelopment of part or all of the male external reproductive organs (which include the penis, the scrotum and the urethra)." ; oboInOwl:hasAlternativeId "HP:0008710", "HP:0008721" ; oboInOwl:hasDbXref "UMLS:C1852534" ; oboInOwl:hasExactSynonym "Hypoplastic male genitalia", "Small male external genitalia", "Underdeveloped male genitalia" ; oboInOwl:id "HP:0000050" ; a owl:Class ; rdfs:label "Hypoplastic male external genitalia" ; rdfs:subClassOf obo:HP_0000032, obo:HP_0003241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000051 obo:IAO_0000115 "Hypospadias with location of the urethral meatus in the perineal region." ; oboInOwl:hasDbXref "SNOMEDCT_US:204890004", "UMLS:C0452148" ; oboInOwl:id "HP:0000051" ; a owl:Class ; rdfs:label "Perineal hypospadias" ; rdfs:subClassOf obo:HP_0000047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002356 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000052 obo:IAO_0000115 "Congenital anomaly characterized by closure or failure to develop an opening in the urethra in males." ; oboInOwl:hasDbXref "UMLS:C4025894" ; oboInOwl:id "HP:0000052" ; a owl:Class ; rdfs:label "Urethral atresia, male" ; rdfs:subClassOf obo:HP_0000068 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000053 obo:IAO_0000115 "The presence of abnormally large testes." ; oboInOwl:hasDbXref "UMLS:C1263023" ; oboInOwl:hasExactSynonym "Large testicles", "Large testis" ; oboInOwl:id "HP:0000053" ; a owl:Class ; rdfs:label "Macroorchidism" ; rdfs:subClassOf obo:HP_0045058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000054 obo:IAO_0000115 "Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm." ; oboInOwl:hasAlternativeId "HP:0000038" ; oboInOwl:hasDbXref "SNOMEDCT_US:34911001", "UMLS:C4551492" ; oboInOwl:hasExactSynonym "Short penis", "Small penis" ; oboInOwl:id "HP:0000054" ; a owl:Class ; rdfs:label "Micropenis" ; rdfs:subClassOf obo:HP_0008736 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000055 obo:IAO_0000115 "An abnormality of the female external genitalia." ; oboInOwl:hasDbXref "UMLS:C4021822" ; oboInOwl:hasExactSynonym "Abnormal female external genitalia" ; oboInOwl:id "HP:0000055" ; a owl:Class ; rdfs:label "Abnormality of female external genitalia" ; rdfs:subClassOf obo:HP_0000811, obo:HP_0010460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000056 obo:IAO_0000115 "An abnormality of the clitoris." ; oboInOwl:hasDbXref "UMLS:C4025893" ; oboInOwl:hasExactSynonym "Abnormality of the clit" ; oboInOwl:id "HP:0000056" ; a owl:Class ; rdfs:label "Abnormality of the clitoris" ; rdfs:subClassOf obo:HP_0000055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000057 obo:IAO_0100001 "HP:0008665" ; a owl:Class ; rdfs:label "obsolete Clitoromegaly" ; owl:deprecated true . obo:HP_0000058 obo:IAO_0000115 "An anomaly of the labia, the externally visible portions of the vulva." ; oboInOwl:hasDbXref "UMLS:C4025892" ; oboInOwl:hasExactSynonym "Abnormality of the labia" ; oboInOwl:id "HP:0000058" ; a owl:Class ; rdfs:label "Abnormal labia morphology" ; rdfs:subClassOf obo:HP_0000055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000059 obo:IAO_0000115 "Undergrowth of the outer labia." ; oboInOwl:hasDbXref "SNOMEDCT_US:289469003", "UMLS:C0566899" ; oboInOwl:hasExactSynonym "Hypoplasia of labia majora", "Small labia majora", "Underdeveloped vaginal lips" ; oboInOwl:id "HP:0000059" ; a owl:Class ; rdfs:label "Hypoplastic labia majora" ; rdfs:subClassOf obo:HP_0000066, obo:HP_0012881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000060 obo:IAO_0000115 "Developmental hypoplasia of the clitoris." ; oboInOwl:hasDbXref "UMLS:C1844527" ; oboInOwl:hasExactSynonym "Hypoplastic clitoris", "Small clitoris", "Underdeveloped clit" ; oboInOwl:id "HP:0000060" ; a owl:Class ; rdfs:label "Clitoral hypoplasia" ; rdfs:subClassOf obo:HP_0012815, obo:HP_0040255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000061 obo:IAO_0000115 "Ambiguous genitalia in an individual with XX genetic gender." ; oboInOwl:hasAlternativeId "HP:0008690" ; oboInOwl:hasDbXref "UMLS:C1859980", "UMLS:C4025891" ; oboInOwl:hasExactSynonym "Atypical appearance of female genitals" ; oboInOwl:hasRelatedSynonym "Ambiguous genitalia due to virilization" ; oboInOwl:id "HP:0000061" ; a owl:Class ; rdfs:label "Ambiguous genitalia, female" ; rdfs:subClassOf obo:HP_0000055, obo:HP_0000062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000062 obo:IAO_0000115 "A genital phenotype that is not clearly assignable to a single gender. Ambiguous genitalia can be evaluated using the Prader scale: Prader 0: Normal female external genitalia. Prader 1: Female external genitalia with clitoromegaly. Prader 2: Clitoromegaly with partial labial fusion forming a funnel-shaped urogenital sinus. Prader 3: Increased phallic enlargement. Complete labioscrotal fusion forming a urogenital sinus with a single opening. Prader 4: Complete scrotal fusion with urogenital opening at the base or on the shaft of the phallus. Prader 5: Normal male external genitalia. The diagnosis of ambiguous genitalia is made for Prader 1-4." ; oboInOwl:hasAlternativeId "HP:0008685", "HP:0008693" ; oboInOwl:hasDbXref "MSH:D012734", "SNOMEDCT_US:21321009", "UMLS:C0266362" ; oboInOwl:hasExactSynonym "Ambiguous external genitalia", "Ambiguous external genitalia at birth", "Intersex genitalia" ; oboInOwl:id "HP:0000062" ; a owl:Class ; rdfs:comment "Note that this term can include or combine variations in size and shape, with partial or complete absence of structures. It is preferable to describe the individual components, which are defined below. It is nonetheless a widely used bundled term and as such is retained here. The distinction of this finding from a marked degree of Hypospadias is an example of how this term can be problematic. Genetic gender is determined at fertilization, whereby the presence of a Y chromosome determines male gender. Normally, genetic gender determines gonadal gender which in turn determines phenotypic gender. Testicular development is an active process requiring expression of the primary testis determining gene SRY, which is located on the Y chromosome." ; rdfs:label "Ambiguous genitalia" ; rdfs:subClassOf obo:HP_0000811 . obo:HP_0000063 obo:IAO_0000115 "Fusion of the labia minora as a result of labial adhesions resulting in vaginal obstruction." ; oboInOwl:hasDbXref "UMLS:C1837532" ; oboInOwl:hasExactSynonym "Fused inner lips" ; oboInOwl:id "HP:0000063" ; a owl:Class ; rdfs:label "Fused labia minora" ; rdfs:subClassOf obo:HP_0012880 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000064 oboInOwl:hasDbXref "UMLS:C1849295" ; oboInOwl:hasExactSynonym "Underdeveloped inner lips" ; oboInOwl:id "HP:0000064" ; a owl:Class ; rdfs:label "Hypoplastic labia minora" ; rdfs:subClassOf obo:HP_0000066, obo:HP_0012880 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000065 oboInOwl:hasDbXref "SNOMEDCT_US:16924008", "UMLS:C0404531" ; oboInOwl:hasExactSynonym "Enlarged vaginal lips", "Enlargement of the labia", "Enlargement of the vaginal lips" ; oboInOwl:id "HP:0000065" ; a owl:Class ; rdfs:label "Labial hypertrophy" ; rdfs:subClassOf obo:HP_0000058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000066 oboInOwl:hasDbXref "UMLS:C1850325" ; oboInOwl:hasExactSynonym "Hypoplastic labia", "Underdeveloped labia" ; oboInOwl:id "HP:0000066" ; a owl:Class ; rdfs:label "Labial hypoplasia" ; rdfs:subClassOf obo:HP_0000058, obo:HP_0012815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000067 obo:IAO_0000115 "Congenital anomaly characterized by closure or failure to develop an opening in the urethra in females." ; oboInOwl:hasDbXref "UMLS:C4025890" ; oboInOwl:id "HP:0000067" ; a owl:Class ; rdfs:label "Urethral atresia, female" ; rdfs:subClassOf obo:HP_0000055, obo:HP_0000068 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000068 obo:IAO_0000115 "Congenital anomaly characterized by closure or failure to develop an opening in the urethra." ; oboInOwl:hasDbXref "UMLS:C1610065" ; oboInOwl:hasExactSynonym "Absent urethral opening", "Urethral opening absent" ; oboInOwl:id "HP:0000068" ; a owl:Class ; rdfs:label "Urethral atresia" ; rdfs:subClassOf obo:HP_0000795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000057 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000069 obo:IAO_0000115 "An abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder." ; oboInOwl:hasAlternativeId "HP:0006001" ; oboInOwl:hasDbXref "UMLS:C1840382" ; oboInOwl:hasExactSynonym "Abnormality of the ureters", "Ureter issue", "Ureteral anomalies" ; oboInOwl:id "HP:0000069" ; a owl:Class ; rdfs:label "Abnormality of the ureter" ; rdfs:subClassOf obo:HP_0010935 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000070 obo:IAO_0000115 "A ureterocele is a congenital saccular dilatation of the distal segment of the ureter." ; oboInOwl:hasDbXref "MSH:D014518", "SNOMEDCT_US:12818004", "UMLS:C0041960" ; oboInOwl:id "HP:0000070" ; a owl:Class ; rdfs:label "Ureterocele" ; rdfs:subClassOf obo:HP_0025633 . obo:HP_0000071 obo:IAO_0000115 "The presence of a stenotic, i.e., constricted ureter." ; oboInOwl:hasDbXref "SNOMEDCT_US:95574003", "UMLS:C0521618" ; oboInOwl:hasExactSynonym "Narrowing of the ureter" ; oboInOwl:id "HP:0000071" ; a owl:Class ; rdfs:label "Ureteral stenosis" ; rdfs:subClassOf obo:HP_0006000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000072 obo:IAO_0000115 "The distention of the ureter with urine." ; oboInOwl:hasAlternativeId "HP:0006003" ; oboInOwl:hasDbXref "SNOMEDCT_US:69758005", "SNOMEDCT_US:95576001", "UMLS:C0521620", "UMLS:C4020897" ; oboInOwl:hasExactSynonym "Dilated ureter", "Megaureter", "Swelling of ureter", "Ureteral dilatation", "Wide ureter" ; oboInOwl:hasRelatedSynonym "Uroureter" ; oboInOwl:id "HP:0000072" ; a owl:Class ; rdfs:label "Hydroureter" ; rdfs:subClassOf obo:HP_0025633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001602 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000073 obo:IAO_0000115 "A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder." ; oboInOwl:hasDbXref "SNOMEDCT_US:49496001", "UMLS:C0221365" ; oboInOwl:hasExactSynonym "Double ureter" ; oboInOwl:id "HP:0000073" ; a owl:Class ; rdfs:label "Ureteral duplication" ; rdfs:subClassOf obo:HP_0025633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000074 obo:IAO_0000115 "Blockage of urine flow from the renal pelvis to the proximal ureter." ; oboInOwl:hasDbXref "MSH:C537373", "SNOMEDCT_US:95575002", "UMLS:C0521619" ; oboInOwl:hasExactSynonym "Pelviureteric junction obstruction", "Ureteropelvic junction stenosis" ; oboInOwl:id "HP:0000074" ; a owl:Class ; rdfs:label "Ureteropelvic junction obstruction" ; rdfs:subClassOf obo:HP_0000071 . obo:HP_0000075 obo:IAO_0000115 "A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T12:45:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:30275001", "UMLS:C0266298" ; oboInOwl:hasExactSynonym "Extra kidney" ; oboInOwl:hasRelatedSynonym "Supernumerary kidney" ; oboInOwl:id "HP:0000075" ; a owl:Class ; rdfs:label "Renal duplication" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000076 obo:IAO_0000115 "Abnormal (retrograde) movement of urine from the bladder into ureters or kidneys related to inadequacy of the valvular mechanism at the ureterovesicular junction or other causes." ; oboInOwl:hasAlternativeId "HP:0005998", "HP:0006002", "HP:0008667" ; oboInOwl:hasDbXref "Fyler:4510", "MSH:D014718", "SNOMEDCT_US:197811007", "UMLS:C0042580" ; oboInOwl:hasExactSynonym "Ureteral reflux", "Ureteric reflux", "Vesico-ureteral reflux", "Vesicoureteric reflux" ; oboInOwl:id "HP:0000076" ; a owl:Class ; rdfs:label "Vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0000009, obo:HP_0025634 . obo:HP_0000077 obo:IAO_0000115 "An abnormality of the kidney." ; oboInOwl:hasDbXref "MSH:D007674", "SNOMEDCT_US:44513007", "SNOMEDCT_US:90708001", "UMLS:C0022658", "UMLS:C0266292" ; oboInOwl:hasExactSynonym "Abnormal kidney", "Abnormality of the kidney", "Renal anomalies", "Renal anomaly" ; oboInOwl:id "HP:0000077" ; a owl:Class ; rdfs:comment "The kidney is a paired organ whose primary function is the production of urine." ; rdfs:label "Abnormality of the kidney" ; rdfs:subClassOf obo:HP_0010935 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000078 obo:IAO_0000115 "An abnormality of the genital system." ; oboInOwl:hasDbXref "UMLS:C0281966", "UMLS:C0744356" ; oboInOwl:hasExactSynonym "Genital abnormalities", "Genital abnormality", "Genital anomalies", "Genital defects" ; oboInOwl:hasRelatedSynonym "Abnormality of the reproductive system" ; oboInOwl:id "HP:0000078" ; a owl:Class ; rdfs:label "Abnormality of the genital system" ; rdfs:subClassOf obo:HP_0000119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000079 obo:IAO_0000115 "An abnormality of the urinary system." ; oboInOwl:hasDbXref "UMLS:C4021821" ; oboInOwl:hasExactSynonym "Urinary tract abnormalities", "Urinary tract abnormality", "Urinary tract anomalies" ; oboInOwl:id "HP:0000079" ; a owl:Class ; rdfs:label "Abnormality of the urinary system" ; rdfs:subClassOf obo:HP_0000119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000080 obo:IAO_0000115 "An abnormal functionality of the genital system." ; oboInOwl:hasBroadSynonym "Abnormality of genital physiology" ; oboInOwl:hasDbXref "UMLS:C4020896", "UMLS:C4021820" ; oboInOwl:hasExactSynonym "Abnormality of reproductive system physiology", "Genital functional abnormality" ; oboInOwl:id "HP:0000080" ; a owl:Class ; rdfs:label "Abnormality of reproductive system physiology" ; rdfs:subClassOf obo:HP_0000078 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000081 obo:IAO_0000115 "A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T12:45:00Z" ; oboInOwl:hasDbXref "UMLS:C1858565" ; oboInOwl:hasExactSynonym "Double collecting system", "Double urinary collecting systems on intravenous pyelography", "Duplex collecting system", "Duplicated renal collecting system" ; oboInOwl:id "HP:0000081" ; a owl:Class ; rdfs:label "Duplicated collecting system" ; rdfs:subClassOf obo:HP_0004742 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000083 obo:IAO_0000115 "A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism." ; oboInOwl:hasAlternativeId "HP:0000084", "HP:0004723" ; oboInOwl:hasDbXref "MSH:D051437", "SNOMEDCT_US:236423003", "SNOMEDCT_US:42399005", "UMLS:C0035078", "UMLS:C1565489", "UMLS:C1839604" ; oboInOwl:hasExactSynonym "Renal failure", "Renal failure in adulthood" ; oboInOwl:id "HP:0000083" ; a owl:Class ; rdfs:label "Renal insufficiency" ; rdfs:subClassOf obo:HP_0012211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000085 obo:IAO_0000115 "A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline." ; oboInOwl:hasBroadSynonym "Fused kidneys" ; oboInOwl:hasDbXref "Fyler:4507", "MSH:D000069337", "SNOMEDCT_US:41729002", "UMLS:C0221353" ; oboInOwl:hasExactSynonym "Horseshoe kidney", "Horseshoe kidneys" ; oboInOwl:id "HP:0000085" ; a owl:Class ; rdfs:label "Horseshoe kidney" ; rdfs:subClassOf obo:HP_0100542 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001879 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000086 obo:IAO_0000115 "A developmental defect in which a kidney is located in an abnormal anatomic position." ; oboInOwl:hasDbXref "SNOMEDCT_US:16507009", "UMLS:C0238207" ; oboInOwl:hasExactSynonym "Abnormal kidney location", "Displaced kidney", "Ectopic kidneys", "Renal ectopia" ; oboInOwl:id "HP:0000086" ; a owl:Class ; rdfs:label "Ectopic kidney" ; rdfs:subClassOf obo:HP_0100542 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000089 obo:IAO_0000115 "Hypoplasia of the kidney." ; oboInOwl:hasAlternativeId "HP:0001968", "HP:0004741", "HP:0008641" ; oboInOwl:hasDbXref "SNOMEDCT_US:32659003", "UMLS:C0266295" ; oboInOwl:hasExactSynonym "Hypoplastic kidney", "Hypoplastic kidneys", "Small kidneys", "Underdeveloped kidneys" ; oboInOwl:id "HP:0000089" ; a owl:Class ; rdfs:comment "Oligomeganephronic renal hypoplasia differs from simple hypoplasia, in which the renal mass is reduced but the number of nephrons is normal." ; rdfs:label "Renal hypoplasia" ; rdfs:subClassOf obo:HP_0008678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000090 obo:IAO_0000115 "Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis." ; oboInOwl:hasAlternativeId "HP:0004748" ; oboInOwl:hasDbXref "SNOMEDCT_US:204958008", "UMLS:C0687120" ; oboInOwl:hasExactSynonym "juvenile nephronophthisis" ; oboInOwl:id "HP:0000090" ; a owl:Class ; rdfs:comment "Nephronophthisis is here regarded as a phenotypic feature. The disease of the same name results in progressive symmetrical destruction of the kidneys involving both the tubules and glomeruli." ; rdfs:label "Nephronophthisis" ; rdfs:subClassOf obo:HP_0100957 . obo:HP_0000091 obo:IAO_0000115 "An abnormality of the renal tubules." ; oboInOwl:hasDbXref "UMLS:C4021826" ; oboInOwl:hasExactSynonym "Abnormality of the renal tubule", "Morphologic abnormality of the renal tubules" ; oboInOwl:id "HP:0000091" ; a owl:Class ; rdfs:comment "The renal tubules are reabsorptive canals that are involved in the secreting, collecting, and conducting of the urine." ; rdfs:label "Abnormal renal tubule morphology" ; rdfs:subClassOf obo:HP_0012575 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001231 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000092 obo:IAO_0000115 "The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules." ; oboInOwl:hasAlternativeId "HP:0005578" ; oboInOwl:hasDbXref "UMLS:C1858395" ; oboInOwl:hasExactSynonym "Renal tubular cell atrophy", "Tubular atrophy" ; oboInOwl:id "HP:0000092" ; a owl:Class ; rdfs:comment "Atrophic tubules must be distinguished from acute tubular injury as both can show extensive tubular epithelial changes. In acute tubular injury, tubules are often dilated and tubular basement membranes are smooth and maintain normal thickness, in contrast to the contracted tubules with thickened and wrinkled tubular basement membranes of tubular atrophy. Further, in acute tubular injury, tubules are usually back-to-back or mildly separated by interstitial edema, while in tubular atrophy tubules can be separated by interstitial fibrosis. Uniform thickening of tubular basement membranes without shrinkage and otherwise healthy epithelial cells can be seen in diabetic nephropathy. Duplication, or lamellation, thickening, and disruption of tubular basement membranes with tubular dilatation can be seen in medullary cystic kidney disease/nephronophthisis." ; rdfs:label "Renal tubular atrophy" ; rdfs:subClassOf obo:HP_0032599 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001231 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000093 obo:IAO_0000115 "Increased levels of protein in the urine." ; oboInOwl:hasDbXref "MSH:D011507", "SNOMEDCT_US:29738008", "UMLS:C0033687" ; oboInOwl:hasExactSynonym "High urine protein levels", "Protein in urine" ; oboInOwl:id "HP:0000093" ; a owl:Class ; rdfs:label "Proteinuria" ; rdfs:subClassOf obo:HP_0020129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16541 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000095 obo:IAO_0000115 "A structural anomaly of the glomerulus." ; oboInOwl:hasDbXref "UMLS:C4025889" ; oboInOwl:hasExactSynonym "Abnormality of renal glomerulus morphology", "Morphologic abnormality of the renal glomerulus" ; oboInOwl:id "HP:0000095" ; a owl:Class ; rdfs:comment "Each human kidney contains approximately one million nephrons. The glomerulus is the most proximal component of the nephron. The glomerulus of the mammalian kidney is a highly developed vascular bed that acts as a filter, allowing a filtrate of small molecules, such as water, sugars, electrolytes and small proteins, to pass through a barrier that retains high molecular weight proteins and cells in the circulation." ; rdfs:label "Abnormal renal glomerulus morphology" ; rdfs:subClassOf obo:HP_0012575, obo:HP_0031263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000096 obo:IAO_0000115 "Accumulation of scar tissue within the glomerulus." ; oboInOwl:hasAlternativeId "HP:0030761" ; oboInOwl:hasBroadSynonym "Renal glomerular fibrosis" ; oboInOwl:hasDbXref "SNOMEDCT_US:197661001", "SNOMEDCT_US:82646005", "UMLS:C0178664" ; oboInOwl:hasExactSynonym "Glomerulosclerosis" ; oboInOwl:id "HP:0000096" ; a owl:Class ; rdfs:label "Glomerular sclerosis" ; rdfs:subClassOf obo:HP_0000095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000097 obo:IAO_0000115 "Segmental accumulation of scar tissue in individual (but not all) glomeruli." ; oboInOwl:hasAlternativeId "HP:0004747" ; oboInOwl:hasDbXref "MSH:D005923", "SNOMEDCT_US:236403004", "SNOMEDCT_US:25821008", "UMLS:C0017668" ; oboInOwl:hasExactSynonym "Focal and segmental glomerular sclerosis", "Focal and segmental glomerulosclerosis", "focal glomerulosclerosis" ; oboInOwl:id "HP:0000097" ; a owl:Class ; rdfs:comment "Glomerular changes can be focal (only in some glomeruli) or diffuse (in all or almost all the glomeruli), and segmental (only a part of the glomerulus) or global (the entire glomerulus). FSGS is characterized by focal and segmental occurrence of lesions with mesangial sclerosis, obliteration of glomerular capillaries with hyalinosis and intracapillary foam cells, formation of adhesions between the glomerular tuft and Bowman's capsule, and podocyte hypertrophy. FSGS is not a disease entity, but rather a pattern of injury with quite diverse clinical behavior, morphology, and possibly also pathogenesis." ; rdfs:label "Focal segmental glomerulosclerosis" ; rdfs:subClassOf obo:HP_0000096 . obo:HP_0000098 obo:IAO_0000115 "A height above that which is expected according to age and gender norms." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T02:21:00Z" ; oboInOwl:hasAlternativeId "HP:0001527", "HP:0003515", "HP:0003516" ; oboInOwl:hasDbXref "SNOMEDCT_US:248328003", "UMLS:C0241240" ; oboInOwl:hasExactSynonym "Accelerated linear growth", "Increased body height", "Increased linear growth", "Tall stature" ; oboInOwl:id "HP:0000098" ; a owl:Class ; rdfs:label "Tall stature" ; rdfs:subClassOf obo:HP_0000002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000099 obo:IAO_0000115 "Inflammation of the renal glomeruli." ; oboInOwl:hasDbXref "MSH:D005921", "SNOMEDCT_US:36171008", "UMLS:C0017658" ; oboInOwl:hasExactSynonym "Glomerular nephritis" ; oboInOwl:id "HP:0000099" ; a owl:Class ; rdfs:label "Glomerulonephritis" ; rdfs:subClassOf obo:HP_0000095, obo:HP_0000123 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_197 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000100 obo:IAO_0000115 "Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia." ; oboInOwl:hasAlternativeId "HP:0000801", "HP:0004718", "HP:0008638", "HP:0008727" ; oboInOwl:hasDbXref "MSH:D009404", "SNOMEDCT_US:52254009", "UMLS:C0027726" ; oboInOwl:hasExactSynonym "Nephrosis" ; oboInOwl:id "HP:0000100" ; a owl:Class ; rdfs:comment "In adults, nephrotic syndrome is characterized by protein excretion of 3.5 g or more per day. In children, nephrotic syndrome is accompanied by protein excretion of more than 40 mg/m2/h and hypalbuminemia < 2.5 mg/dl." ; rdfs:label "Nephrotic syndrome" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0000103 obo:IAO_0000115 "An increased rate of urine production." ; oboInOwl:hasAlternativeId "HP:0200060" ; oboInOwl:hasDbXref "MSH:D011141", "SNOMEDCT_US:28442001", "SNOMEDCT_US:56574000", "SNOMEDCT_US:718402002", "UMLS:C0032617" ; oboInOwl:hasExactSynonym "Increased urine output" ; oboInOwl:id "HP:0000103" ; a owl:Class ; rdfs:comment "An excessive volume of urination for an adult is more than 2.5 liters of urine per day." ; rdfs:label "Polyuria" ; rdfs:subClassOf obo:HP_0012590 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000104 obo:IAO_0000115 "Agenesis, that is, failure of the kidney to develop during embryogenesis and development." ; oboInOwl:hasAlternativeId "HP:0000785", "HP:0004745", "HP:0008680" ; oboInOwl:hasDbXref "Fyler:4503", "SNOMEDCT_US:204942005", "UMLS:C0542519" ; oboInOwl:hasExactSynonym "Absent kidney", "Missing kidney", "Renal aplasia" ; oboInOwl:id "HP:0000104" ; a owl:Class ; rdfs:comment "Renal agenesis can occur as a unilateral or bilateral trait." ; rdfs:label "Renal agenesis" ; rdfs:subClassOf obo:HP_0008678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000105 obo:IAO_0000115 "An abnormal increase in the size of the kidney." ; oboInOwl:hasDbXref "SNOMEDCT_US:300444006", "UMLS:C0542518" ; oboInOwl:hasExactSynonym "Enlarged kidney", "Large kidneys", "Nephromegaly", "Renal enlargement" ; oboInOwl:hasRelatedSynonym "Large kidney" ; oboInOwl:id "HP:0000105" ; a owl:Class ; rdfs:comment "The main causes of large kidney are hydronephrosis, polycystic disease, renal cell carcinoma, nephroblastoma/Wilms tumor (in children), and solitary cysts. If possible, a specific term should be used instead of this one. There are several ways of diagnosing enlarged kidney including intravenous urography." ; rdfs:label "Enlarged kidney" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000107 obo:IAO_0000115 "A fluid filled sac in the kidney." ; oboInOwl:hasAlternativeId "HP:0000088", "HP:0000109" ; oboInOwl:hasDbXref "MSH:D052177", "UMLS:C0022679", "UMLS:C3887499" ; oboInOwl:hasExactSynonym "Kidney cyst" ; oboInOwl:hasRelatedSynonym "Cystic kidney disease", "Cystic kidneys", "Renal cysts" ; oboInOwl:id "HP:0000107" ; a owl:Class ; rdfs:label "Renal cyst" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000108 obo:IAO_0000115 "The presence of multiple cysts at the border between the renal cortex and medulla." ; oboInOwl:hasDbXref "UMLS:C1968619" ; oboInOwl:hasExactSynonym "Corticomedullary renal cysts" ; oboInOwl:hasRelatedSynonym "Renal corticomedullary cystic disease" ; oboInOwl:id "HP:0000108" ; a owl:Class ; rdfs:label "Renal corticomedullary cysts" ; rdfs:subClassOf obo:HP_0000107, obo:HP_0011035, obo:HP_0100957 . obo:HP_0000110 obo:IAO_0000115 "The presence of developmental dysplasia of the kidney." ; oboInOwl:hasAlternativeId "HP:0000116", "HP:0004721" ; oboInOwl:hasDbXref "MSH:C563261", "SNOMEDCT_US:204949001", "UMLS:C1619700", "UMLS:C3536714" ; oboInOwl:hasExactSynonym "Dysplastic kidneys", "Renal adysplasia" ; oboInOwl:id "HP:0000110" ; a owl:Class ; rdfs:label "Renal dysplasia" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000111 obo:IAO_0000115 "Increased number and size of the juxtaglomerular cells." ; oboInOwl:hasDbXref "UMLS:C1866496" ; oboInOwl:id "HP:0000111" ; a owl:Class ; rdfs:label "Renal juxtaglomerular cell hypertrophy/hyperplasia" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0000112 obo:IAO_0000115 "A nonspecific term referring to disease or damage of the kidneys." ; oboInOwl:hasBroadSynonym "Kidney damage", "Kidney disease" ; oboInOwl:hasDbXref "MSH:D007674", "SNOMEDCT_US:90708001", "UMLS:C0022658", "UMLS:C1408258" ; oboInOwl:id "HP:0000112" ; a owl:Class ; rdfs:label "Nephropathy" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0000113 obo:IAO_0000115 "The presence of multiple cysts in both kidneys." ; oboInOwl:hasAlternativeId "HP:0004716", "HP:0004739", "HP:0004740", "HP:0008645", "HP:0008673", "HP:0008699" ; oboInOwl:hasDbXref "Fyler:4508", "MSH:D007690", "SNOMEDCT_US:82525005", "UMLS:C0022680", "UMLS:C1567435" ; oboInOwl:hasExactSynonym "Enlarged polycystic kidneys", "Polycystic kidneys" ; oboInOwl:hasRelatedSynonym "Polycystic kidney disease" ; oboInOwl:id "HP:0000113" ; a owl:Class ; rdfs:comment "Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. Most commonly, PKD arises as an inherited trait. Tremendous enlargement of both kidneys is characteristic of the autosomal dominant form of PKD, with up to hundreds or thousands of renal cysts. This term does not refer to the disease entity but rather to the finding of numerous cysts in both kidneys." ; rdfs:label "Polycystic kidney dysplasia" ; rdfs:subClassOf obo:HP_0000107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002089 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000114 obo:IAO_0000115 "Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle." ; oboInOwl:hasAlternativeId "HP:0000806" ; oboInOwl:hasDbXref "UMLS:C1839603" ; oboInOwl:hasExactSynonym "Proximal renal tubule defect", "Proximal renal tubulopathy", "Proximal tubular defect", "Proximal tubule dysfunction", "Selective proximal tubular damage" ; oboInOwl:id "HP:0000114" ; a owl:Class ; rdfs:label "Proximal tubulopathy" ; rdfs:subClassOf obo:HP_0000124 . obo:HP_0000117 obo:IAO_0000115 "High urine phosphate in the presence of hypophosphatemia." ; oboInOwl:hasDbXref "UMLS:C1845169" ; oboInOwl:hasExactSynonym "Decreased renal tubular phosphate reabsorption", "Decreased tubular maximum for phosphate reabsorption per glomerular filtration rate", "Tubular phosphate reabsorption low" ; oboInOwl:id "HP:0000117" ; a owl:Class ; rdfs:label "Renal phosphate wasting" ; rdfs:subClassOf obo:HP_0012599 . obo:HP_0000118 obo:IAO_0000115 "A phenotypic abnormality." ; oboInOwl:hasDbXref "UMLS:C4021819" ; oboInOwl:hasExactSynonym "Organ abnormality" ; oboInOwl:id "HP:0000118" ; a owl:Class ; rdfs:comment "This is the root of the phenotypic abnormality subontology of the HPO." ; rdfs:label "Phenotypic abnormality" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0000119 obo:IAO_0000115 "The presence of any abnormality of the genitourinary system." ; oboInOwl:hasAlternativeId "HP:0008658", "HP:0008688", "HP:0008704", "HP:0008713" ; oboInOwl:hasDbXref "MSH:D014564", "SNOMEDCT_US:287085006", "SNOMEDCT_US:42030000", "UMLS:C0042063", "UMLS:C0080276", "UMLS:C4020895" ; oboInOwl:hasExactSynonym "Abnormality of the GU system", "Genitourinary abnormality", "Genitourinary tract anomalies", "Genitourinary tract malformation", "Urogenital abnormalities", "Urogenital anomalies" ; oboInOwl:hasRelatedSynonym "Genitourinary disease", "Genitourinary dysplasia" ; oboInOwl:id "HP:0000119" ; a owl:Class ; rdfs:label "Abnormality of the genitourinary system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004122 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000121 obo:IAO_0000115 "Nephrocalcinosis is the deposition of calcium salts in renal parenchyma." ; oboInOwl:hasDbXref "MSH:D009397", "SNOMEDCT_US:48638002", "UMLS:C0027709", "UMLS:C4280679" ; oboInOwl:hasExactSynonym "Too much calcium deposited in kidneys" ; oboInOwl:hasRelatedSynonym "Increased calcium level in kidney" ; oboInOwl:id "HP:0000121" ; a owl:Class ; rdfs:comment "Nephrocalcinosis can be intratubular or interstitial, and can be diagnosed by means of a radiologic exam (plain radiographs, ultrasonograms, or computed tomography scans) or via microscopic examination of the renal tissues. The term nephrocalcinosis most often applies to a generalized increase in renal calcium content." ; rdfs:label "Nephrocalcinosis" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000122 obo:IAO_0000115 "A unilateral form of agenesis of the kidney." ; oboInOwl:hasDbXref "Fyler:4509", "SNOMEDCT_US:55726006", "UMLS:C0266294" ; oboInOwl:hasExactSynonym "Absent kidney on one side", "Missing one kidney", "Single kidney", "Unilateral kidney agenesis" ; oboInOwl:id "HP:0000122" ; a owl:Class ; rdfs:label "Unilateral renal agenesis" ; rdfs:subClassOf obo:HP_0000104 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0000123 obo:IAO_0000115 "The presence of inflammation affecting the kidney." ; oboInOwl:hasAlternativeId "HP:0008634" ; oboInOwl:hasDbXref "MSH:D009393", "SNOMEDCT_US:52845002", "UMLS:C0027697" ; oboInOwl:hasExactSynonym "Kidney inflammation" ; oboInOwl:id "HP:0000123" ; a owl:Class ; rdfs:label "Nephritis" ; rdfs:subClassOf obo:HP_0012211, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000124 obo:IAO_0000115 "Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid." ; oboInOwl:hasDbXref "SNOMEDCT_US:95568003", "UMLS:C0151747" ; oboInOwl:hasExactSynonym "Abnormal function of filtrating structures in kidney", "Renal tubular defect" ; oboInOwl:hasRelatedSynonym "Renal tubular disease" ; oboInOwl:id "HP:0000124" ; a owl:Class ; rdfs:label "Renal tubular dysfunction" ; rdfs:subClassOf obo:HP_0012211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001231 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000125 obo:IAO_0000115 "A developmental defect in which a kidney is located in an abnormal anatomic position within the pelvis." ; oboInOwl:hasDbXref "SNOMEDCT_US:56108007", "UMLS:C0221209" ; oboInOwl:hasExactSynonym "Sacral kidney" ; oboInOwl:id "HP:0000125" ; a owl:Class ; rdfs:label "Pelvic kidney" ; rdfs:subClassOf obo:HP_0000086 . obo:HP_0000126 obo:IAO_0000115 "Severe distention of the kidney with dilation of the renal pelvis and calices." ; oboInOwl:hasDbXref "Fyler:4502", "MSH:D006869", "SNOMEDCT_US:43064006", "UMLS:C0020295" ; oboInOwl:id "HP:0000126" ; a owl:Class ; rdfs:comment "Hydronephrosis can be caused by reflux or by retrograde pressure on the kidney when the flow of urine is obstructed." ; rdfs:label "Hydronephrosis" ; rdfs:subClassOf obo:HP_0010946 . obo:HP_0000127 obo:IAO_0000115 "A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s)." ; oboInOwl:hasDbXref "UMLS:C1846347" ; oboInOwl:hasExactSynonym "Loss of salt in urine", "Renal salt-wasting", "Salt wasting", "Salt-wasting" ; oboInOwl:id "HP:0000127" ; a owl:Class ; rdfs:label "Renal salt wasting" ; rdfs:subClassOf obo:HP_0012591 . obo:HP_0000128 obo:IAO_0000115 "High urine potassium in the presence of hypokalemia." ; oboInOwl:hasDbXref "UMLS:C1846348" ; oboInOwl:hasExactSynonym "Renal K wasting" ; oboInOwl:id "HP:0000128" ; a owl:Class ; rdfs:comment "A urine potassium assay can be used to determine the cause of reduced serum potassium (hypokalemia). Normally, the kidney will reabsorb more potassium in the presence of hypokalemia. Therefore, a low urine potassium can suggest gastrointestinal potassium loss, poor dietary intake, or a shift of potassium from the extracellular to the intracellular space. On the other hand, a high urine potassium in the face of low serum potassium indicated renal loss, referred to as renal potassium wasting." ; rdfs:label "Renal potassium wasting" ; rdfs:subClassOf obo:HP_0012598 . obo:HP_0000130 obo:IAO_0000115 "An abnormality of the uterus." ; oboInOwl:hasAlternativeId "HP:0008630", "HP:0008692" ; oboInOwl:hasDbXref "MSH:C562565", "SNOMEDCT_US:37849005", "UMLS:C0266383" ; oboInOwl:hasExactSynonym "Abnormality of the uterus", "Uterine abnormalities", "Uterine malformations" ; oboInOwl:id "HP:0000130" ; a owl:Class ; rdfs:label "Abnormality of the uterus" ; rdfs:subClassOf obo:HP_0000008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000131 obo:IAO_0000115 "The presence of a leiomyoma of the uterus." ; oboInOwl:hasAlternativeId "HP:0008642" ; oboInOwl:hasDbXref "MSH:D007889", "NCIT:C3157", "SNOMEDCT_US:146801000119103", "SNOMEDCT_US:44598004", "SNOMEDCT_US:95315005", "UMLS:C0042133" ; oboInOwl:hasExactSynonym "Benign uterine leiomyomas", "Uterine fibroid" ; oboInOwl:id "HP:0000131" ; a owl:Class ; rdfs:comment "Leiomyoma is a benign neoplasm derived from smooth muscle cells." ; rdfs:label "Uterine leiomyoma" ; rdfs:subClassOf obo:HP_0010784 . obo:HP_0000132 obo:IAO_0000115 "Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days." ; oboInOwl:hasAlternativeId "HP:0100609" ; oboInOwl:hasDbXref "MSH:D008595", "SNOMEDCT_US:386692008", "UMLS:C0025323" ; oboInOwl:hasExactSynonym "Abnormally heavy bleeding during menstruation", "Abnormally heavy periods", "Hypermenorrhea" ; oboInOwl:id "HP:0000132" ; a owl:Class ; rdfs:label "Menorrhagia" ; rdfs:subClassOf obo:HP_0000140, obo:HP_0001892 . obo:HP_0000133 oboInOwl:hasAlternativeId "HP:0003243" ; oboInOwl:hasDbXref "MSH:D006059", "MSH:D006060", "SNOMEDCT_US:205681004", "SNOMEDCT_US:38804009", "SNOMEDCT_US:83579008", "SNOMEDCT_US:95219002", "UMLS:C0018051", "UMLS:C0018055", "UMLS:C0687149" ; oboInOwl:hasExactSynonym "Mixed gonadal dysgenesis", "Pure gonadal dysgenesis" ; oboInOwl:id "HP:0000133" ; a owl:Class ; rdfs:label "Gonadal dysgenesis" ; rdfs:subClassOf obo:HP_0000812 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000991 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000134 obo:IAO_0000115 "Decreased functionality of the female gonads, i.e., of the ovary." ; oboInOwl:hasDbXref "SNOMEDCT_US:16041008", "UMLS:C0271578" ; oboInOwl:hasExactSynonym "Hypogonadism, female" ; oboInOwl:id "HP:0000134" ; a owl:Class ; rdfs:label "Female hypogonadism" ; rdfs:subClassOf obo:HP_0000135, obo:HP_0031066 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000135 obo:IAO_0000115 "A decreased functionality of the gonad." ; oboInOwl:hasDbXref "MSH:D007006", "SNOMEDCT_US:48130008", "UMLS:C0020619" ; oboInOwl:hasExactSynonym "Decreased activity of gonads" ; oboInOwl:id "HP:0000135" ; a owl:Class ; rdfs:comment "Reduced functioning of the gonads (ovaries or testes) with reduced production of sex hormones." ; rdfs:label "Hypogonadism" ; rdfs:subClassOf obo:HP_0000080, obo:HP_0008373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000991 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000136 obo:IAO_0000115 "The presence of a bifid uterus." ; oboInOwl:hasDbXref "UMLS:C1850327" ; oboInOwl:id "HP:0000136" ; a owl:Class ; rdfs:comment "A uterus that is divided into two lateral horns as a result of imperfect fusion of the paramesonephric ducts." ; rdfs:label "Bifid uterus" ; rdfs:subClassOf obo:HP_0031105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000137 obo:IAO_0000115 "An abnormality of the ovary." ; oboInOwl:hasDbXref "MSH:D010049", "SNOMEDCT_US:5552004", "UMLS:C0029928", "UMLS:C4021818" ; oboInOwl:hasExactSynonym "Abnormality of the ovaries", "Abnormality of the ovary" ; oboInOwl:hasRelatedSynonym "Ovarian disease" ; oboInOwl:id "HP:0000137" ; a owl:Class ; rdfs:label "Abnormality of the ovary" ; rdfs:subClassOf obo:HP_0000008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000138 obo:IAO_0000115 "The presence of one or more cysts of the ovary." ; oboInOwl:hasAlternativeId "HP:0000146" ; oboInOwl:hasDbXref "MSH:D010048", "SNOMEDCT_US:79883001", "UMLS:C0029927" ; oboInOwl:hasExactSynonym "Cystic abnormalities of the ovaries", "Cystic ovaries", "Ovarian cyst", "Ovarian cystic abnormality" ; oboInOwl:id "HP:0000138" ; a owl:Class ; rdfs:label "Ovarian cyst" ; rdfs:subClassOf obo:HP_0031065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000139 obo:IAO_0000115 "The presence of prolapse of the uterus." ; oboInOwl:hasAlternativeId "HP:0100824" ; oboInOwl:hasDbXref "MSH:D014596", "SNOMEDCT_US:24976005", "UMLS:C0042140" ; oboInOwl:hasExactSynonym "Sagging uterus" ; oboInOwl:id "HP:0000139" ; a owl:Class ; rdfs:comment "The uterus (womb) is normally held in place by a muscles, tissue and ligaments. If these tissues can no longer support the uterus it can slip down from its normal position." ; rdfs:label "Uterine prolapse" ; rdfs:subClassOf obo:HP_0031105, obo:HP_0100823 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000140 obo:IAO_0000115 "An abnormality of the ovulation cycle." ; oboInOwl:hasDbXref "UMLS:C3549779", "UMLS:C4025888" ; oboInOwl:hasExactSynonym "Abnormality of the menstrual cycle" ; oboInOwl:hasRelatedSynonym "Menstrual abnormalities" ; oboInOwl:id "HP:0000140" ; a owl:Class ; rdfs:label "Abnormality of the menstrual cycle" ; rdfs:subClassOf obo:HP_0030012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000141 obo:IAO_0000115 "Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months." ; oboInOwl:hasDbXref "UMLS:C2219717" ; oboInOwl:hasExactSynonym "Abnormal absence of menstruation" ; oboInOwl:id "HP:0000141" ; a owl:Class ; rdfs:label "Amenorrhea" ; rdfs:subClassOf obo:HP_0000140 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000142 obo:IAO_0000115 "Any structural abnormality of the vagina." ; oboInOwl:hasAlternativeId "HP:0008650" ; oboInOwl:hasDbXref "UMLS:C1856023" ; oboInOwl:hasExactSynonym "Vaginal malformation" ; oboInOwl:id "HP:0000142" ; a owl:Class ; rdfs:label "Abnormal vagina morphology" ; rdfs:subClassOf obo:HP_0000008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000143 obo:IAO_0000115 "The presence of a fistula between the vagina and the rectum." ; oboInOwl:hasDbXref "MEDDRA:10051097", "MSH:D012006", "SNOMEDCT_US:65619001", "UMLS:C0034895" ; oboInOwl:hasExactSynonym "Abnormal connection between rectum and vagina" ; oboInOwl:id "HP:0000143" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Rectovaginal fistula" ; rdfs:subClassOf obo:HP_0004320, obo:HP_0100590 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000144 oboInOwl:hasDbXref "SNOMEDCT_US:17276009", "UMLS:C0520927" ; oboInOwl:hasExactSynonym "Abnormal fertility", "Decreased fertility" ; oboInOwl:id "HP:0000144" ; a owl:Class ; rdfs:label "Decreased fertility" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0000145 oboInOwl:hasDbXref "UMLS:C1856006" ; oboInOwl:hasExactSynonym "Transverse vaginal membrane" ; oboInOwl:id "HP:0000145" ; a owl:Class ; rdfs:label "Transverse vaginal septum" ; rdfs:subClassOf obo:HP_0001153 . obo:HP_0000147 oboInOwl:hasAlternativeId "HP:0008644", "HP:0008657" ; oboInOwl:hasDbXref "MSH:D011085", "SNOMEDCT_US:69878008", "UMLS:C0032460", "UMLS:C1136382" ; oboInOwl:hasExactSynonym "Polycystic ovary", "Sclerocystic ovaries" ; oboInOwl:hasRelatedSynonym "Polycystic ovary disease" ; oboInOwl:id "HP:0000147" ; a owl:Class ; rdfs:label "Polycystic ovaries" ; rdfs:subClassOf obo:HP_0000138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002089 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000148 obo:IAO_0000115 "Congenital occlusion of the vagina or adhesion of the walls of the vagina causing occlusion." ; oboInOwl:hasDbXref "SNOMEDCT_US:87380008", "UMLS:C1321884" ; oboInOwl:hasExactSynonym "Abnormally closed or absent vagina" ; oboInOwl:id "HP:0000148" ; a owl:Class ; rdfs:label "Vaginal atresia" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0001827 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000149 obo:IAO_0000115 "The presence of a gonadoblastoma of the ovary." ; oboInOwl:hasDbXref "NCIT:C3754", "SNOMEDCT_US:716594002", "UMLS:C1518716" ; oboInOwl:hasExactSynonym "Gonadoblastoma, female" ; oboInOwl:id "HP:0000149" ; a owl:Class ; rdfs:comment "Gonadoblastoma is a rare benign tumor that has the potential for malignant transformation and affects a subset of patients with an intersex disorder or disorder of sex development." ; rdfs:label "Ovarian gonadoblastoma" ; rdfs:subClassOf obo:HP_0000150, obo:HP_0100615 . obo:HP_0000150 obo:IAO_0000115 "The presence of a gonadoblastoma, a neoplasm of a gonad that consists of aggregates of germ cells and sex cord elements." ; oboInOwl:hasAlternativeId "HP:0006745" ; oboInOwl:hasDbXref "MSH:D018238", "NCIT:C3754", "SNOMEDCT_US:74751003", "UMLS:C0206661" ; oboInOwl:id "HP:0000150" ; a owl:Class ; rdfs:label "Gonadoblastoma" ; rdfs:subClassOf obo:HP_0000812, obo:HP_0100728 . obo:HP_0000151 obo:IAO_0000115 "Aplasia of the uterus." ; oboInOwl:hasDbXref "SNOMEDCT_US:248942000", "UMLS:C0425913" ; oboInOwl:hasExactSynonym "Absent uterus", "uterus absent" ; oboInOwl:id "HP:0000151" ; a owl:Class ; rdfs:label "Aplasia of the uterus" ; rdfs:subClassOf obo:HP_0008684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000152 obo:IAO_0000115 "An abnormality of head and neck." ; oboInOwl:hasDbXref "UMLS:C4021817" ; oboInOwl:hasExactSynonym "Abnormality of head or neck", "Head and neck abnormality" ; oboInOwl:id "HP:0000152" ; a owl:Class ; rdfs:label "Abnormality of head or neck" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007811 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000153 obo:IAO_0000115 "An abnormality of the mouth." ; oboInOwl:hasDbXref "MSH:D009056", "SNOMEDCT_US:128334002", "UMLS:C0026633" ; oboInOwl:hasExactSynonym "Abnormal mouth", "Abnormality of the mouth" ; oboInOwl:id "HP:0000153" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the mouth" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000154 obo:IAO_0000115 "Distance between the oral commissures more than 2 SD above the mean. Alternatively, an apparently increased width of the oral aperture (subjective)." ; oboInOwl:hasAlternativeId "HP:0000181", "HP:0002052" ; oboInOwl:hasDbXref "MSH:D008265", "SNOMEDCT_US:40159009", "UMLS:C0024433" ; oboInOwl:hasExactSynonym "Broad mouth", "Large mouth", "Large oral aperture", "Macrostomia", "Wide mouth" ; oboInOwl:id "HP:0000154" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The width of the mouth varies with facial movement and must be assessed when the subject has a relaxed (neutral) face. This term replaces macrostomia, large mouth, and large oral aperture because these terms imply a wide and open mouth. The term should not be used to describe a patient with a lateral oral cleft." ; rdfs:label "Wide mouth" ; rdfs:subClassOf obo:HP_0011337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000155 obo:IAO_0000115 "Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue." ; oboInOwl:hasBroadSynonym "Mouth sore" ; oboInOwl:hasDbXref "MSH:D019226", "SNOMEDCT_US:26284000", "UMLS:C0149745" ; oboInOwl:hasExactSynonym "Mouth ulcer", "Oral mucosal ulceration" ; oboInOwl:id "HP:0000155" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Oral ulcer" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0000157 obo:IAO_0000115 "Any abnormality of the tongue." ; oboInOwl:hasDbXref "UMLS:C0878638" ; oboInOwl:hasExactSynonym "Abnormal tongue", "Abnormality of the tongue", "Glossal abnormality", "Lingual abnormality", "Tongue abnormality" ; oboInOwl:id "HP:0000157" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the tongue" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000158 obo:IAO_0000115 "Increased length and width of the tongue." ; oboInOwl:hasAlternativeId "HP:0000203" ; oboInOwl:hasBroadSynonym "Glossal hypertrophy", "Lingual hyperplasia", "Lingual hypertrophy" ; oboInOwl:hasDbXref "MSH:D008260", "SNOMEDCT_US:25273001", "UMLS:C0024421" ; oboInOwl:hasExactSynonym "Abnormally large tongue", "Hyperplasia of the tongue", "Hypertrophy of the tongue", "Increased size of tongue", "Large tongue", "Tongue hypertrophy" ; oboInOwl:id "HP:0000158" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Normal standards do not exist. Large size usually leads to protrusion of the tongue. This is an acknowledged bundled term, but due to its frequent usage and relative paucity of situations that would call for separate individual assessments of tongue dimensions, the bundled term is retained. Micrognathia may give the false appearance of a large tongue." ; rdfs:label "Macroglossia" ; rdfs:subClassOf obo:HP_0003712, obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000159 obo:IAO_0000115 "An abnormality of the lip." ; oboInOwl:hasDbXref "UMLS:C2183966" ; oboInOwl:hasExactSynonym "Abnormal lip", "Abnormality of the lip", "Lip abnormality" ; oboInOwl:hasNarrowSynonym "Anomaly of lip", "Deformity of lip", "Malformation of lip" ; oboInOwl:id "HP:0000159" ; a owl:Class ; rdfs:label "Abnormal lip morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000160 obo:IAO_0000115 "Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective)." ; oboInOwl:hasAlternativeId "HP:0002261", "HP:0009095", "HP:0009096" ; oboInOwl:hasDbXref "MSH:D008865", "SNOMEDCT_US:14582003", "UMLS:C0026034" ; oboInOwl:hasExactSynonym "Microstomia", "Narrow mouth", "Small mouth", "Small oral aperture" ; oboInOwl:id "HP:0000160" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The width of the mouth varies with facial movement and must be assessed when the subject has a relaxed (neutral) face. This term replaces microstomia, small oral aperture, and small mouth because the reduced opening of the mouth is secondary to reduced width." ; rdfs:label "Narrow mouth" ; rdfs:subClassOf obo:HP_0011337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000161 obo:IAO_0000115 "A type of cleft lip presenting as a midline (median) gap in the upper lip." ; oboInOwl:hasDbXref "UMLS:C1850256" ; oboInOwl:hasExactSynonym "Central cleft upper lip", "Midline cleft lip" ; oboInOwl:id "HP:0000161" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Median cleft lip" ; rdfs:subClassOf obo:HP_0000204 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002169 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000162 obo:IAO_0000115 "Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly." ; oboInOwl:hasBroadSynonym "Posterior displacement of the tongue" ; oboInOwl:hasDbXref "MSH:D065710", "SNOMEDCT_US:3639002", "UMLS:C0267048", "UMLS:C4280678" ; oboInOwl:hasExactSynonym "Lingual retraction", "Retraction of the tongue" ; oboInOwl:id "HP:0000162" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Presumably, use of the suffix ptosis refers to the situation where the patient is supine, and the displacement is downward. Strictly speaking, the term glossoptosis indicates falling of the tongue and thus can also be forward displacement; however by convention it is only used for backward displacement. Glossoptosis may cause obstruction of the airway." ; rdfs:label "Glossoptosis" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001922 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000163 obo:IAO_0000115 "Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth." ; oboInOwl:hasDbXref "UMLS:C4025887" ; oboInOwl:hasExactSynonym "Abnormality of the oral cavity" ; oboInOwl:id "HP:0000163" ; a owl:Class ; rdfs:label "Abnormal oral cavity morphology" ; rdfs:subClassOf obo:HP_0031816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000167 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000164 obo:IAO_0000115 "Any abnormality of the teeth." ; oboInOwl:hasAlternativeId "HP:0001567", "HP:0006296", "HP:0006348" ; oboInOwl:hasDbXref "MSH:D014071", "SNOMEDCT_US:422775003", "UMLS:C0040427", "UMLS:C0262444" ; oboInOwl:hasExactSynonym "Abnormal dentition", "Abnormal teeth", "Dental abnormalities", "Dental abnormality", "Dental anomalies" ; oboInOwl:hasRelatedSynonym "Abnormality of the teeth", "Dental problem", "Dental problems", "Tooth abnormalities" ; oboInOwl:id "HP:0000164" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Any abnormality of the primary (deciduous) or permanent teeth." ; rdfs:label "Abnormality of the dentition" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000166 obo:IAO_0000115 "A severe form of periodontitis." ; oboInOwl:hasBroadSynonym "Severe gum disease" ; oboInOwl:hasDbXref "UMLS:C4025886" ; oboInOwl:hasExactSynonym "Severe periodontal disease", "Severe pyorrhea" ; oboInOwl:id "HP:0000166" ; a owl:Class ; rdfs:label "Severe periodontitis" ; rdfs:subClassOf obo:HP_0000704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000704 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000168 obo:IAO_0000115 "Any abnormality of the gingiva (also known as gums)." ; oboInOwl:hasDbXref "UMLS:C4021816" ; oboInOwl:hasExactSynonym "Abnormality of the gums", "Gingival abnormality" ; oboInOwl:id "HP:0000168" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The gingiva consists of the mucosal tissue that lies over the alveolar bone and around the base of the teeth." ; rdfs:label "Abnormality of the gingiva" ; rdfs:subClassOf obo:HP_0011830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001828 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000169 obo:IAO_0000115 "The presence of fibrosis of the gingiva." ; oboInOwl:hasDbXref "MSH:C562884", "MSH:D005351", "NCIT:C3041", "SNOMEDCT_US:109620006", "SNOMEDCT_US:58569000", "UMLS:C0016049", "UMLS:C0399440", "UMLS:C4280677" ; oboInOwl:hasExactSynonym "Gingival fibroma", "Gingival fibrous nodules" ; oboInOwl:hasNarrowSynonym "Hereditary gingival fibromatosis", "Idiopathic gingival hyperplasia" ; oboInOwl:id "HP:0000169" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Gingival fibromatosis is characterized by a slowly progressive benign enlargement of the oral gingival tissues. Both genetic and pharmacologically induced forms of gingival fibromatosis are known. The most common genetic form, hereditary gingival fibromatosis (HGF), is usually transmitted as an autosomal dominant trait, although sporadic cases are common and autosomal recessive inheritance has been reported." ; rdfs:label "Gingival fibromatosis" ; rdfs:subClassOf obo:HP_0000168, obo:HP_0010614 . obo:HP_0000171 obo:IAO_0000115 "Decreased length and width of the tongue." ; oboInOwl:hasAlternativeId "HP:0000226", "HP:0009079" ; oboInOwl:hasDbXref "MSH:D014060", "SNOMEDCT_US:249380003", "SNOMEDCT_US:32614006", "UMLS:C0025988", "UMLS:C0426492" ; oboInOwl:hasExactSynonym "Abnormally small tongue", "Decreased size of tongue", "Hypoglossia", "Hypoplasia of the tongue", "Hypoplastic tongue", "Lingual hypoplasia", "Rudimentary tongue", "Small tongue", "Underdevelopment of the tongue" ; oboInOwl:id "HP:0000171" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Normal standards do not exist. The term aglossia is often used for extremely small tongue, but a nubbin of tongue tissue is almost always present and aglossia in sensu strictu is extremely rare. This is an acknowledged bundled term, but due to its frequent usage and relative paucity of situations that would call for separate individual assessments of tongue dimensions, the bundled term is retained." ; rdfs:label "Microglossia" ; rdfs:subClassOf obo:HP_0010295 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000172 obo:IAO_0000115 "Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate." ; oboInOwl:hasDbXref "UMLS:C4025885" ; oboInOwl:hasExactSynonym "Abnormality of palatine uvula", "Abnormality of the uvula" ; oboInOwl:id "HP:0000172" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal uvula morphology" ; rdfs:subClassOf obo:HP_0100736 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000174 obo:IAO_0000115 "Any abnormality of the palate, i.e., of roof of the mouth." ; oboInOwl:hasDbXref "UMLS:C4021815" ; oboInOwl:hasExactSynonym "Abnormality of the palate", "Abnormality of the roof of the mouth", "Palatal anomaly", "Palate abnormality" ; oboInOwl:id "HP:0000174" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal palate morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000175 obo:IAO_0000115 "Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate)." ; oboInOwl:hasAlternativeId "HP:0410004" ; oboInOwl:hasBroadSynonym "Cleft secondary palate" ; oboInOwl:hasDbXref "Fyler:4876", "MSH:D002972", "SNOMEDCT_US:63567004", "SNOMEDCT_US:87979003", "UMLS:C0008925", "UMLS:C2981150" ; oboInOwl:hasExactSynonym "Cleft hard and soft palate", "Cleft of hard and soft palate", "Cleft of palate", "Cleft palate", "Cleft roof of mouth", "Palatoschisis", "Uranostaphyloschisis" ; oboInOwl:id "HP:0000175" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Cleft palate is a developmental defect that occurs between the 7th and 12th week of pregnancy. Normally, the palatine processes fuse during this time to form the soft and hard palate. A failure of fusion results in a cleft palate. The clinical spectrum ranges from bifid uvula, to (incomplete or complete) cleft of the soft palate, up to (complete or incomplete) cleft of both the soft and hard palate." ; rdfs:label "Cleft palate" ; rdfs:subClassOf obo:HP_0000174, obo:HP_0000202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000176 obo:IAO_0000115 "Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate." ; oboInOwl:hasAlternativeId "HP:0000208", "HP:0002746", "HP:0009091" ; oboInOwl:hasDbXref "SNOMEDCT_US:43437003", "UMLS:C0432103", "UMLS:C4020894" ; oboInOwl:hasExactSynonym "Partial thickness cleft hard palate", "Submucosal cleft palate" ; oboInOwl:hasRelatedSynonym "Submucous clefting" ; oboInOwl:id "HP:0000176" ; a owl:Class ; rdfs:label "Submucous cleft hard palate" ; rdfs:subClassOf obo:HP_0410031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000177 obo:IAO_0000115 "An abnormality of the upper lip." ; oboInOwl:hasDbXref "UMLS:C4025884" ; oboInOwl:hasExactSynonym "Abnormality of upper lip" ; oboInOwl:hasNarrowSynonym "Anomaly of the upper lip", "Deformity of the upper lip", "Malformation of the upper lip" ; oboInOwl:id "HP:0000177" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal upper lip morphology" ; rdfs:subClassOf obo:HP_0000159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000178 obo:IAO_0000115 "An abnormality of the lower lip." ; oboInOwl:hasDbXref "UMLS:C4025883" ; oboInOwl:hasExactSynonym "Abnormality of lower lip" ; oboInOwl:hasNarrowSynonym "Anomaly of the lower lip", "Deformity of the lower lip", "Malformation of the lower lip" ; oboInOwl:id "HP:0000178" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal lower lip morphology" ; rdfs:subClassOf obo:HP_0000159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000179 obo:IAO_0000115 "Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective)." ; oboInOwl:hasAlternativeId "HP:0000170" ; oboInOwl:hasDbXref "UMLS:C1839739", "UMLS:C2053437" ; oboInOwl:hasExactSynonym "Full lower lip vermilion", "Increased height of lower lip vermilion", "Increased volume of lower lip", "Increased volume of lower lip vermilion", "Plump lower lip", "Prominent lower lip", "Thick vermilion border of lower lip" ; oboInOwl:hasNarrowSynonym "Prominent lower lip vermilion", "Thick red part of the lower lip" ; oboInOwl:hasRelatedSynonym "Full lower lip", "Thick lower lip" ; oboInOwl:id "HP:0000179" ; a owl:Class ; rdfs:comment "Normal values for the height of the vermilion are available [Farkas, 1981] but measurements are not commonly used. Most clinicians determine this feature subjectively. The lower lip is typically thicker than the upper one. The height of the vermilion of the lower lip varies among ethnic groups, and the vermilion should be compared to a population of same ethnic background. When the vermilion is thick, it is more convex and more everted than usual on profile view, but that should be assessed separately." ; rdfs:label "Thick lower lip vermilion" ; rdfs:subClassOf obo:HP_0000178, obo:HP_0012471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000180 obo:IAO_0000115 "Multiple indentations and/or elevations on the edge and/or surface of the tongue producing an irregular surface contour." ; oboInOwl:hasDbXref "SNOMEDCT_US:253752000", "UMLS:C0431564" ; oboInOwl:hasExactSynonym "Bumpy tongue", "Lingual lobules", "Lobulate tongue" ; oboInOwl:id "HP:0000180" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Lobulated tongue can bilobed, trilobed, or show multiple lobes." ; rdfs:label "Lobulated tongue" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0000182 oboInOwl:hasDbXref "UMLS:C4025882" ; oboInOwl:hasExactSynonym "Abnormality of lingual movement", "Movement abnormality of the tongue" ; oboInOwl:id "HP:0000182" ; a owl:Class ; rdfs:label "Movement abnormality of the tongue" ; rdfs:subClassOf obo:HP_0030810 . obo:HP_0000183 oboInOwl:hasDbXref "UMLS:C1853406", "UMLS:C4280676" ; oboInOwl:hasExactSynonym "Difficulty in lingual movements", "Difficulty in tongue movements" ; oboInOwl:hasNarrowSynonym "Hypokinesia of the tongue", "Lingual hypokinesia" ; oboInOwl:id "HP:0000183" ; a owl:Class ; rdfs:label "Difficulty in tongue movements" ; rdfs:subClassOf obo:HP_0000182 . obo:HP_0000185 obo:IAO_0000115 "Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency." ; oboInOwl:hasDbXref "MSH:C562950", "SNOMEDCT_US:253997002", "UMLS:C0432098" ; oboInOwl:hasExactSynonym "Cleft muscular palate", "Cleft of soft palate", "Cleft velum" ; oboInOwl:id "HP:0000185" ; a owl:Class ; rdfs:label "Cleft soft palate" ; rdfs:subClassOf obo:HP_0000175, obo:HP_0100736 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001733 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000187 oboInOwl:hasDbXref "UMLS:C1857500", "UMLS:C4280675" ; oboInOwl:hasExactSynonym "Broad alveolar margins", "Widened alveolar ridges" ; oboInOwl:hasRelatedSynonym "Broad alveolar processes of jaw", "Wide alveolar margins", "Wide alveolar processes of jaw", "Wide gum ridges" ; oboInOwl:id "HP:0000187" ; a owl:Class ; rdfs:label "Broad alveolar ridges" ; rdfs:subClassOf obo:HP_0006477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000188 obo:IAO_0000115 "Decreased width of the upper lip." ; oboInOwl:hasAlternativeId "HP:0200087" ; oboInOwl:hasDbXref "UMLS:C1848977" ; oboInOwl:hasExactSynonym "Decreased height of upper lip", "Decreased upper labial height", "Decreased upper labial length", "Decreased vertical length of upper lip", "Short upper lip", "Shortening of upper lip", "Vertical deficiency of upper lip" ; oboInOwl:id "HP:0000188" ; a owl:Class ; rdfs:label "Short upper lip" ; rdfs:subClassOf obo:HP_0000177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000189 obo:IAO_0000115 "Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective)." ; oboInOwl:hasDbXref "UMLS:C1398312" ; oboInOwl:hasExactSynonym "Decreased palatal width", "Decreased transverse dimension of palate", "Narrow palate", "Narrow roof of mouth" ; oboInOwl:id "HP:0000189" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Palatal width is measured as the distance between the maxillary first permanent molar on the right and left sides, at the lingual cervical line, using a specific device. Palate width is typically assessed subjectively in routine clinical practice. Narrowing is often associated with a High palate, but this should be assessed and coded separately. Gingival overgrowth can give the impression of a narrow palate but should be distinguished and coded separately. The term gothic palate is used to indicate that the roof of the palate is not round but rather has an inverted V-shape, and therefore, only the upper part of the palate is narrow." ; rdfs:label "Narrow palate" ; rdfs:subClassOf obo:HP_0000174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000190 obo:IAO_0000115 "An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity." ; oboInOwl:hasDbXref "UMLS:C4025881" ; oboInOwl:hasExactSynonym "Abnormality of frenum of tongue", "Abnormality of lingual frenum", "Abnormality of oral frenula", "Abnormality of oral frenum" ; oboInOwl:id "HP:0000190" ; a owl:Class ; rdfs:comment "A frenulum is a small frenum. There are several frena that are usually present in a normal oral cavity, most notably the maxillary labial frenum, the mandibular labial frenum, and the lingual frenum." ; rdfs:label "Abnormal oral frenulum morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000191 obo:IAO_0000115 "Extra fold of tissue extending from the alveolar ridge to the inner surface of the upper or lower lip." ; oboInOwl:hasDbXref "UMLS:C4021814" ; oboInOwl:hasExactSynonym "Accessory oral frenum", "Extra oral frenulum", "Extra oral frenum", "Multiple oral frenula", "Supernumerary oral frenulum", "Supernumerary oral frenum" ; oboInOwl:id "HP:0000191" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is assessed by gently retracting the oral mucosa from the alveolar ridge. Typically there is a single maxillary and a single mandibular frenulum located in the midline between the two central incisors. Abnormalities of the alveolar ridges may accompany accessory frenula, but these should be assessed separately." ; rdfs:label "Accessory oral frenulum" ; rdfs:subClassOf obo:HP_0000190 . obo:HP_0000193 obo:IAO_0000115 "Uvula separated into two parts most easily seen at the tip." ; oboInOwl:hasAlternativeId "HP:0000173", "HP:0410032" ; oboInOwl:hasDbXref "SNOMEDCT_US:18910001", "UMLS:C0266122" ; oboInOwl:hasExactSynonym "Bifid palatine uvula", "Cleft of uvula", "Cleft uvula", "Forked uvula", "Split uvula", "Uvula bifida" ; oboInOwl:id "HP:0000193" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bifid uvula" ; rdfs:subClassOf obo:HP_0000172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000194 obo:IAO_0000115 "A facial appearance characterized by a permanently or nearly permanently opened mouth." ; oboInOwl:hasDbXref "SNOMEDCT_US:262016004", "UMLS:C0240379" ; oboInOwl:hasExactSynonym "Gaped jawed appearance", "Gaped mouthed appearance", "Open mouth", "Slack jawed appearance" ; oboInOwl:hasRelatedSynonym "Open mouth appearance" ; oboInOwl:id "HP:0000194" ; a owl:Class ; rdfs:label "Open mouth" ; rdfs:subClassOf obo:HP_0011338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000610 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000196 obo:IAO_0000115 "Depression located on the vermilion of the lower lip, usually paramedian." ; oboInOwl:hasDbXref "UMLS:C1861544" ; oboInOwl:id "HP:0000196" ; a owl:Class ; rdfs:comment "A lip pit may be connected by a fistula to mucous minor salivary glands in the lower lip. In addition, a lip pit may on occasion be seen with a surrounding tissue elevation (mound). Pits located at the labial commisure (cheilon) are distinct from lip pits (see Commissural pit)." ; rdfs:label "Lower lip pit" ; rdfs:subClassOf obo:HP_0000178, obo:HP_0100269 . obo:HP_0000197 obo:IAO_0000115 "Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear." ; oboInOwl:hasDbXref "UMLS:C4025880" ; oboInOwl:hasExactSynonym "Abnormality of parotid gland", "Anomaly of the parotid gland" ; oboInOwl:id "HP:0000197" ; a owl:Class ; rdfs:label "Abnormal parotid gland morphology" ; rdfs:subClassOf obo:HP_0010286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001831 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000198 oboInOwl:hasDbXref "UMLS:C1858569", "UMLS:C4280674" ; oboInOwl:hasExactSynonym "Absence of parotid duct", "Absent stensen duct", "Failure of development of parotid duct", "Failure of development of stensen duct", "Missing parotid duct", "Missing stensen duct" ; oboInOwl:hasNarrowSynonym "Agenesis of parotid duct", "Agenesis of stensen duct" ; oboInOwl:id "HP:0000198" ; a owl:Class ; rdfs:label "Absence of Stensen duct" ; rdfs:subClassOf obo:HP_0000197 . obo:HP_0000199 oboInOwl:hasDbXref "UMLS:C0241438" ; oboInOwl:hasExactSynonym "Lingual nodules" ; oboInOwl:id "HP:0000199" ; a owl:Class ; rdfs:label "Tongue nodules" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0000200 obo:IAO_0000115 "The presence of an abnormally short lingual frenulum." ; oboInOwl:hasBroadSynonym "Hypoplasia of lingual frenulum", "Hypoplasia of lingual frenum", "Hypoplasia of tongue frenulum", "Hypoplasia of tongue frenum" ; oboInOwl:hasDbXref "SNOMEDCT_US:249388005", "UMLS:C0426501", "UMLS:C4280673" ; oboInOwl:hasExactSynonym "Deficiency of lingual frenulum", "Short lingual frenum", "Short tongue frenulum", "Short tongue frenum", "Tight lingual frenulum" ; oboInOwl:id "HP:0000200" ; a owl:Class ; rdfs:label "Short lingual frenulum" ; rdfs:subClassOf obo:HP_0000190 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000201 obo:IAO_0000115 "Pierre Robin malformation is a sequence of developmental malformations characterized by micrognathia (mandibular hypoplasia), glossoptosis and cleft palate." ; oboInOwl:hasDbXref "MSH:D010855", "SNOMEDCT_US:4602007", "UMLS:C0031900" ; oboInOwl:hasExactSynonym "Pierre Robin sequence", "Pierre-robin anomaly", "Pierre-robin deformity", "Pierre-robin malformation", "Robin sequence" ; oboInOwl:id "HP:0000201" ; a owl:Class ; rdfs:label "Pierre-Robin sequence" ; rdfs:subClassOf obo:HP_0031816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000162 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000175 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000202 obo:IAO_0000115 "The presence of a cleft in the oral cavity, the two main types of which are cleft lip and cleft palate. In cleft lip, there is the congenital failure of the maxillary and median nasal processes to fuse, forming a groove or fissure in the lip. In cleft palate, there is a congenital failure of the palate to fuse properly, forming a grooved depression or fissure in the roof of the mouth. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately." ; oboInOwl:hasDbXref "SNOMEDCT_US:253983005", "SNOMEDCT_US:66948001", "UMLS:C0158646", "UMLS:C4021813" ; oboInOwl:hasExactSynonym "Cleft of the mouth", "Oral cleft", "Oral clefting" ; oboInOwl:hasNarrowSynonym "Cleft lip, cleft palate" ; oboInOwl:hasRelatedSynonym "Cleft lip/palate" ; oboInOwl:id "HP:0000202" ; a owl:Class ; rdfs:label "Orofacial cleft" ; rdfs:subClassOf obo:HP_0000163 . obo:HP_0000204 obo:IAO_0000115 "A gap in the upper lip. This is a congenital defect resulting from nonfusion of tissues of the lip during embryonal development." ; oboInOwl:hasDbXref "Fyler:4875", "MSH:D002971", "SNOMEDCT_US:80281008", "UMLS:C0008924" ; oboInOwl:hasExactSynonym "Cheiloschisis of upper lip", "Cleft upper lip", "Harelip" ; oboInOwl:hasRelatedSynonym "Cleft of upper lip" ; oboInOwl:id "HP:0000204" ; a owl:Class ; rdfs:label "Cleft upper lip" ; rdfs:subClassOf obo:HP_0000177, obo:HP_0410030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000205 obo:IAO_0000115 "An abnormality of the appearance of the face caused by constant contraction of the lips leading to a puckered or pursed appearance." ; oboInOwl:hasDbXref "UMLS:C1832130" ; oboInOwl:hasExactSynonym "Pursed lips", "Tightly closed lips" ; oboInOwl:id "HP:0000205" ; a owl:Class ; rdfs:label "Pursed lips" ; rdfs:subClassOf obo:HP_0011338 . obo:HP_0000206 obo:IAO_0000115 "Inflammation of the tongue." ; oboInOwl:hasDbXref "MSH:D005928", "SNOMEDCT_US:45534005", "UMLS:C0017675" ; oboInOwl:hasExactSynonym "Inflammation of the tongue", "Lingual inflammation", "Smooth swollen tongue" ; oboInOwl:id "HP:0000206" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Glossitis" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0000207 obo:IAO_0000115 "The presence of a triangular form of the mouth." ; oboInOwl:hasDbXref "UMLS:C1849341" ; oboInOwl:hasExactSynonym "Triangular mouth", "Triangular shaped mouth", "Triangular shaped oral aperture" ; oboInOwl:id "HP:0000207" ; a owl:Class ; rdfs:label "Triangular mouth" ; rdfs:subClassOf obo:HP_0011338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000211 obo:IAO_0000115 "Limitation in the ability to open the mouth." ; oboInOwl:hasBroadSynonym "Decrease in jaw mobility", "Decrease in jaw movement", "Decrease in jaw opening", "Decrease in mandibular mobility", "Decrease in mandibular movement", "Decrease in mandibular opening", "Limited jaw mobility", "Limited jaw movement", "Limited jaw opening", "Limited mandibular mobility", "Limited mandibular opening", "Limited mouth opening" ; oboInOwl:hasDbXref "MSH:D014313", "SNOMEDCT_US:87866006", "UMLS:C0041105", "UMLS:C1848474", "UMLS:C4228933", "UMLS:C4280672" ; oboInOwl:hasExactSynonym "Lockjaw", "Pain of muscles of mastication" ; oboInOwl:id "HP:0000211" ; a owl:Class ; rdfs:label "Trismus" ; rdfs:subClassOf obo:HP_0000277 . obo:HP_0000212 obo:IAO_0000115 "Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown." ; oboInOwl:hasAlternativeId "HP:0000195" ; oboInOwl:hasDbXref "MSH:D005885", "MSH:D005886", "MSH:D019214", "SNOMEDCT_US:441787004", "SNOMEDCT_US:441798003", "SNOMEDCT_US:54711002", "UMLS:C0017566", "UMLS:C0017567", "UMLS:C0376480" ; oboInOwl:hasExactSynonym "Gingival enlargement", "Gingival hyperplasia", "Gum enlargement", "Gum hypertrophy", "Hypertrophic gingivitis" ; oboInOwl:hasRelatedSynonym "Oral soft tissue hyperplasia" ; oboInOwl:id "HP:0000212" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is to be distinguished from overgrowth of the alveolar ridge." ; rdfs:label "Gingival overgrowth" ; rdfs:subClassOf obo:HP_0000168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001828 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000214 obo:IAO_0000115 "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the lips." ; oboInOwl:hasDbXref "UMLS:C1857697", "UMLS:C4280670", "UMLS:C4280671" ; oboInOwl:hasExactSynonym "Labial telangiectasia", "Lip telangiectases", "Telangiectasia of the lips" ; oboInOwl:hasRelatedSynonym "Angioectasias of the lip", "Labial angioectasias", "Spider veins of the lip" ; oboInOwl:id "HP:0000214" ; a owl:Class ; rdfs:label "Lip telangiectasia" ; rdfs:subClassOf obo:HP_0000159, obo:HP_0000228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000215 obo:IAO_0000115 "Height of the vermilion of the upper lip in the midline more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the upper lip in the frontal view (subjective)." ; oboInOwl:hasAlternativeId "HP:0000231" ; oboInOwl:hasDbXref "UMLS:C1846423" ; oboInOwl:hasExactSynonym "Full upper lip", "Full upper lip vermilion", "Increased height of upper lip vermilion", "Increased volume of upper lip", "Increased volume of upper lip vermilion", "Plump upper lip", "Prominent upper lip", "Thick upper lip", "Thick vermilion border of upper lip" ; oboInOwl:hasNarrowSynonym "Prominent upper lip vermilion", "Thick red part of the upper lip" ; oboInOwl:id "HP:0000215" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Normal values for the height of the vermilion are available [Farkas, 1981], but measurements are not commonly used. Most clinicians determine this feature subjectively or utilize the Likert scale of Astley and Clarren [2000] (Fig. 17). The vermilion of the upper lip varies considerably among ethnic groups, and the vermilion should be compared to a population of same ethnic background. The thickness of the upper lip vermilion is sensitive to the facial expression. On profile view, a thick vermilion is more convex than usual." ; rdfs:label "Thick upper lip vermilion" ; rdfs:subClassOf obo:HP_0011339, obo:HP_0012471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000216 oboInOwl:hasDbXref "UMLS:C1839276" ; oboInOwl:hasExactSynonym "Secondary alveolar ridges" ; oboInOwl:id "HP:0000216" ; a owl:Class ; rdfs:label "Broad secondary alveolar ridge" ; rdfs:subClassOf obo:HP_0000187 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004527 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000217 obo:IAO_0000115 "Dryness of the mouth due to salivary gland dysfunction." ; oboInOwl:hasAlternativeId "HP:0002709", "HP:0100756" ; oboInOwl:hasBroadSynonym "Decreased salivary flow" ; oboInOwl:hasDbXref "MSH:D014987", "SNOMEDCT_US:300268000", "SNOMEDCT_US:56893005", "SNOMEDCT_US:87715008", "UMLS:C0043352" ; oboInOwl:hasExactSynonym "Dry mouth", "Dry mouth syndrome", "Reduced salivation" ; oboInOwl:id "HP:0000217" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Xerostomia" ; rdfs:subClassOf obo:HP_0100755 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001824 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000218 obo:IAO_0000115 "Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective)." ; oboInOwl:hasAlternativeId "HP:0000156", "HP:0009080", "HP:0009082", "HP:0009097" ; oboInOwl:hasDbXref "SNOMEDCT_US:27272007", "UMLS:C0240635" ; oboInOwl:hasExactSynonym "Elevated palate", "High arched palate", "High palate", "High, arched palate", "High-arched palate", "Increased palatal height", "Palate high-arched", "Palate, high-arched" ; oboInOwl:hasRelatedSynonym "Ogival palate" ; oboInOwl:id "HP:0000218" ; a owl:Class ; rdfs:comment """The measuring device for this assessment is described in (Hall JG, Froster-Iskenius UG, Allanson JE, Gripp K, Slavotinek A. 2006. Handbook of Normal Physical Measurements. 2nd edition. Oxford Medical, publishers). A high palate is often associated with a narrow palate. However, a narrow palate can easily give a false appearance of a high palate. Height and width of the palate should be assessed and coded separately. We do not recommend the subjective determination because this term can be overused and applied inaccurately.""" ; rdfs:label "High palate" ; rdfs:subClassOf obo:HP_0000174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000219 obo:IAO_0000115 "Height of the vermilion of the upper lip in the midline more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the upper lip in the frontal view (subjective)." ; oboInOwl:hasAlternativeId "HP:0200062", "HP:0200086" ; oboInOwl:hasDbXref "UMLS:C1865017" ; oboInOwl:hasExactSynonym "Decreased height of upper lip vermilion", "Decreased volume of upper lip", "Decreased volume of upper lip vermilion", "Thin upper lip", "Thin vermilion border of upper lip" ; oboInOwl:hasNarrowSynonym "Thin red part of the upper lip" ; oboInOwl:hasRelatedSynonym "Thin upper lips" ; oboInOwl:id "HP:0000219" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Normal values for the height of the vermilion are available [Farkas, 1981], but measurements are not commonly used. Most clinicians determine this feature subjectively or use the Likert scale for Caucasians and African Americans [Astley and Clarren, 2000]. The height of the vermilion of the upper lip varies among ethnic groups, and the vermilion should be compared to a population of same ethnic background. The thinness of the upper lip vermilion is sensitive to facial expression. On profile view, a thin vermilion is less convex than usual. A thin upper lip vermilion may be associated with a smooth philtrum and an absence of the Cupid's bow, but these should be assessed separately." ; rdfs:label "Thin upper lip vermilion" ; rdfs:subClassOf obo:HP_0000233, obo:HP_0011339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000220 obo:IAO_0000115 "Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech." ; oboInOwl:hasBroadSynonym "Velopharyngeal dysfunction" ; oboInOwl:hasDbXref "MSH:D014681", "SNOMEDCT_US:229727006", "SNOMEDCT_US:232416001", "SNOMEDCT_US:278714002", "UMLS:C0042454", "UMLS:C4280669" ; oboInOwl:hasExactSynonym "Velopharyngeal incompetence" ; oboInOwl:id "HP:0000220" ; a owl:Class ; rdfs:label "Velopharyngeal insufficiency" ; rdfs:subClassOf obo:HP_0100736 . obo:HP_0000221 obo:IAO_0000115 "Accentuation of the grooves on the dorsal surface of the tongue." ; oboInOwl:hasDbXref "MSH:D014063", "SNOMEDCT_US:52368004", "UMLS:C0040412" ; oboInOwl:hasExactSynonym "Fissured tongue", "Grooved tongue", "Lingua plicata", "Lingual furrow", "Plicated tongue", "Prominent tongue grooves", "Scrotal tongue" ; oboInOwl:id "HP:0000221" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Usually there is a midline groove of the tongue with smaller radiating grooves. The deep furrows may extend to the lateral borders. They may follow a regular geometric pattern or be irregular. A furrowed tongue occurs in 10-25% of individuals but is rare in children." ; rdfs:label "Furrowed tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001948 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000222 obo:IAO_0000115 "Hyperkeratosis of the gingiva." ; oboInOwl:hasAlternativeId "HP:0007539" ; oboInOwl:hasDbXref "UMLS:C1857013" ; oboInOwl:hasExactSynonym "Hyperkeratosis, gingival" ; oboInOwl:id "HP:0000222" ; a owl:Class ; rdfs:comment "The condition results in the teeth being partially or totally engulfed by keratinized gingiva, causing aesthetic and functional problems." ; rdfs:label "Gingival hyperkeratosis" ; rdfs:subClassOf obo:HP_0000168, obo:HP_0000962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001828 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000223 oboInOwl:hasDbXref "UMLS:C4025879" ; oboInOwl:hasExactSynonym "Abnormality of taste sensation" ; oboInOwl:id "HP:0000223" ; a owl:Class ; rdfs:label "Abnormality of taste sensation" ; rdfs:subClassOf obo:HP_0012638, obo:HP_0030810 . obo:HP_0000224 obo:IAO_0000115 "A decreased ability to perceive flavor." ; oboInOwl:hasDbXref "MSH:D000370", "SNOMEDCT_US:697990000", "UMLS:C0151934" ; oboInOwl:hasExactSynonym "Decreased taste", "Decreased taste sensation" ; oboInOwl:id "HP:0000224" ; a owl:Class ; rdfs:label "Hypogeusia" ; rdfs:subClassOf obo:HP_0000223 . obo:HP_0000225 obo:IAO_0000115 "Hemorrhage affecting the gingiva." ; oboInOwl:hasAlternativeId "HP:0000167" ; oboInOwl:hasDbXref "MSH:D005884", "SNOMEDCT_US:86276007", "UMLS:C0017565" ; oboInOwl:hasExactSynonym "Bleeding gums", "Gingival haemorrhage", "Gingival hemorrhage", "Gingivorrhagia" ; oboInOwl:id "HP:0000225" ; a owl:Class ; rdfs:label "Gingival bleeding" ; rdfs:subClassOf obo:HP_0000168, obo:HP_0001892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000227 obo:IAO_0000115 "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the tongue." ; oboInOwl:hasDbXref "UMLS:C4025878", "UMLS:C4280668" ; oboInOwl:hasExactSynonym "Lingual telangiectasia" ; oboInOwl:hasRelatedSynonym "Angioectasias of the tongue", "Lingual angioectasias", "Spider veins of the tongue" ; oboInOwl:id "HP:0000227" ; a owl:Class ; rdfs:label "Tongue telangiectasia" ; rdfs:subClassOf obo:HP_0000228, obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000228 obo:IAO_0000115 "Presence of telangiectases in the oral cavity." ; oboInOwl:hasDbXref "UMLS:C4025877", "UMLS:C4280667" ; oboInOwl:hasExactSynonym "Oral cavity teleangiectasia" ; oboInOwl:hasRelatedSynonym "Angioectasias of the mouth", "Angioectasias of the oral cavity", "Spider veins of the mouth", "Spider veins of the oral cavity" ; oboInOwl:id "HP:0000228" ; a owl:Class ; rdfs:label "Oral cavity telangiectasia" ; rdfs:subClassOf obo:HP_0011830, obo:HP_0100579 . obo:HP_0000230 obo:IAO_0000115 "Inflammation of the gingiva." ; oboInOwl:hasDbXref "MSH:D005891", "SNOMEDCT_US:66383009", "UMLS:C0017574" ; oboInOwl:hasExactSynonym "Gingival inflammation", "Inflamed gums", "Red and swollen gums" ; oboInOwl:id "HP:0000230" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gingivitis" ; rdfs:subClassOf obo:HP_0000168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000232 obo:IAO_0000115 "An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view." ; oboInOwl:hasAlternativeId "HP:0000184", "HP:0002264", "HP:0002712", "HP:0004665", "HP:0009086", "HP:0009093" ; oboInOwl:hasDbXref "UMLS:C1853246", "UMLS:C1866234" ; oboInOwl:hasExactSynonym "Drooping lower lip", "Eclabium of lower lip", "Everted lower lip", "Everted prominent lower lip", "Outward turned lower lip" ; oboInOwl:hasRelatedSynonym "Protruding lower lip" ; oboInOwl:id "HP:0000232" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In frontal view, with the face relaxed, the apparent height of the lower lip vermilion is excessive and the lower incisors may be visible. On profile view, the vermilion is more convex than usual. An everted lower lip may be viewed as pouting, but this designation is a functional term." ; rdfs:label "Everted lower lip vermilion" ; rdfs:subClassOf obo:HP_0000178, obo:HP_0012472 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000233 obo:IAO_0000115 "Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips)." ; oboInOwl:hasAlternativeId "HP:0000213" ; oboInOwl:hasDbXref "SNOMEDCT_US:301348000", "UMLS:C0578038" ; oboInOwl:hasExactSynonym "Decreased volume of lip", "Decreased volume of lip vermillion", "Thin lips", "Thin vermillion" ; oboInOwl:hasRelatedSynonym "Thin vermilion borders" ; oboInOwl:id "HP:0000233" ; a owl:Class ; rdfs:comment "The vermilion is the red part of the lips, and the vermilion border is the rim of paler skin that demarcates the vermilion from the rest of the skin of the face." ; rdfs:label "Thin vermilion border" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0000234 obo:IAO_0000115 "An abnormality of the head." ; oboInOwl:hasDbXref "UMLS:C4021812" ; oboInOwl:hasExactSynonym "Abnormal head", "Abnormality of the head", "Head abnormality" ; oboInOwl:id "HP:0000234" ; a owl:Class ; rdfs:label "Abnormality of the head" ; rdfs:subClassOf obo:HP_0000152 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000235 obo:IAO_0000115 "Any abnormality of the fontanelles (the regions covered by a thick membrane that normally ossify in the first two years of life) or the cranial sutures (the fibrous joints in which the articulating bones or cartilages of the skull are connected by sutural ligaments)." ; oboInOwl:hasDbXref "UMLS:C4025876" ; oboInOwl:id "HP:0000235" ; a owl:Class ; rdfs:comment "Fontanels are the fibrous, membrane-covered gaps created when more than two cranial bones are juxtaposed, as opposed to sutures, which are narrow seams of fibrous connective tissue that separate the flat bones of the skull. At birth, an infant has six fontanels (the anterior and posterior, two mastoid, and two sphenoid). The anterior fontanel is the largest and most important for clinical evaluation. The average size of the anterior fontanel is 2.1 cm, and the median time of closure is 13.8 months." ; rdfs:label "Abnormality of the fontanelles or cranial sutures" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:UBERON_0002221 obo:UBERON_0003685 ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000236 obo:IAO_0000115 "An abnormality of the anterior fontanelle, i.e., the cranial fontanelle that is located at the intersection of the coronal and sagittal sutures." ; oboInOwl:hasDbXref "UMLS:C4025875" ; oboInOwl:hasExactSynonym "Abnormality of the forehead soft spot" ; oboInOwl:id "HP:0000236" ; a owl:Class ; rdfs:label "Abnormality of the anterior fontanelle" ; rdfs:subClassOf obo:HP_0011328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000237 obo:IAO_0000115 "Abnormally decreased size of the anterior fontanelle with respect to age-dependent norms." ; oboInOwl:hasDbXref "UMLS:C1859455" ; oboInOwl:hasExactSynonym "Small anterior fontanel", "Small forehead fontanel" ; oboInOwl:id "HP:0000237" ; a owl:Class ; rdfs:label "Small anterior fontanelle" ; rdfs:subClassOf obo:HP_0000236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000238 obo:IAO_0000115 "Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation." ; oboInOwl:hasAlternativeId "HP:0007189", "HP:0008503" ; oboInOwl:hasDbXref "MSH:D006849", "SNOMEDCT_US:230745008", "UMLS:C0020255" ; oboInOwl:hasExactSynonym "Hydrocephaly", "Nonsyndromal hydrocephalus", "Too much cerebrospinal fluid in the brain" ; oboInOwl:id "HP:0000238" ; a owl:Class ; rdfs:comment "Hydrocephalus results from an imbalance between the rate of production of cerebrospinal fluid (CSF), mainly in the choroid plexus, and its reabsorption in the subarchnoid space over brain and spinal cord." ; rdfs:label "Hydrocephalus" ; rdfs:subClassOf obo:HP_0002118, obo:HP_0002921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004086 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000239 obo:IAO_0000115 "In newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms." ; oboInOwl:hasAlternativeId "HP:0004473" ; oboInOwl:hasDbXref "SNOMEDCT_US:276709006", "UMLS:C0456132", "UMLS:C4072820", "UMLS:C4072821", "UMLS:C4072822" ; oboInOwl:hasExactSynonym "Enlarged fontanelles", "Large fontanel", "Large fontanelle", "Large fontanels", "Persistent wide fontanel", "Wide fontanelles" ; oboInOwl:hasNarrowSynonym "Large bregma sutures", "Large, late-closing fontanelle", "Wide bregma sutures" ; oboInOwl:id "HP:0000239" ; a owl:Class ; rdfs:comment "There are six membrane-covered openings between the cranial sutures in the incompletely ossified skull of the fetus or newborn infant that normally close sometime after birth (anterior fontanel, cranial fontanel, mastoid fontanel, posterior fontanel, sphenoidal fontanel)." ; rdfs:label "Large fontanelles" ; rdfs:subClassOf obo:HP_0011328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000240 obo:IAO_0000115 "Any abnormality of the size of the skull." ; oboInOwl:hasBroadSynonym "Abnormality of head size" ; oboInOwl:hasDbXref "UMLS:C4025874" ; oboInOwl:hasExactSynonym "Abnormality of cranium size", "Abnormality of skull size" ; oboInOwl:id "HP:0000240" ; a owl:Class ; rdfs:label "Abnormality of skull size" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000242 obo:IAO_0000115 "Parietal bossing is a marked prominence in the parietal region." ; oboInOwl:hasAlternativeId "HP:0004641" ; oboInOwl:hasDbXref "UMLS:C1857126" ; oboInOwl:hasExactSynonym "Biparietal bossing", "Bossing of parietal bone" ; oboInOwl:id "HP:0000242" ; a owl:Class ; rdfs:label "Parietal bossing" ; rdfs:subClassOf obo:HP_0002696 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000243 obo:IAO_0000115 "Wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput." ; oboInOwl:hasBroadSynonym "Triangular head shape", "Wedge shaped head" ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:28740008", "UMLS:C0265535", "UMLS:C4280665", "UMLS:C4280666" ; oboInOwl:hasExactSynonym "Triangular cranium shape", "Triangular skull shape", "Wedge shaped cranium", "Wedge shaped skull" ; oboInOwl:id "HP:0000243" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This shape should be assessed from above, with the examiner looking down on the head of the patient. Trigonocephaly can be caused by premature fusion of the metopic suture." ; rdfs:label "Trigonocephaly" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000244 obo:IAO_0000115 "Abnormal vertical height of the skull and a shortening of its anterior-posterior length, frequently combined with malformations of the occipital region." ; oboInOwl:hasDbXref "UMLS:C1857484" ; oboInOwl:hasExactSynonym "Brachy-turricephaly", "High, prominent forehead", "Turribrachycephaly" ; oboInOwl:id "HP:0000244" ; a owl:Class ; rdfs:label "Brachyturricephaly" ; rdfs:subClassOf obo:HP_0000248, obo:HP_0000262 . obo:HP_0000245 obo:IAO_0000115 "Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses." ; oboInOwl:hasBroadSynonym "Abnormality of the sinuses" ; oboInOwl:hasDbXref "UMLS:C4025873" ; oboInOwl:hasExactSynonym "Abnormality of the sinuses of the head" ; oboInOwl:hasRelatedSynonym "Abnormality of the paranasal sinuses" ; oboInOwl:id "HP:0000245" ; a owl:Class ; rdfs:label "Abnormal paranasal sinus morphology" ; rdfs:subClassOf obo:HP_0002087, obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001825 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000246 obo:IAO_0000115 "Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction." ; oboInOwl:hasBroadSynonym "Sinus infection" ; oboInOwl:hasDbXref "MSH:D010254", "MSH:D012852", "SNOMEDCT_US:36971009", "SNOMEDCT_US:7393007", "UMLS:C0030469", "UMLS:C0037199" ; oboInOwl:hasExactSynonym "Sinus inflammation" ; oboInOwl:hasRelatedSynonym "Sinus disease" ; oboInOwl:id "HP:0000246" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sinusitis" ; rdfs:subClassOf obo:HP_0000245, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001825 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000248 obo:IAO_0000115 "An abnormality of skull shape characterized by a decreased anterior-posterior diameter. That is, a cephalic index greater than 81%. Alternatively, an apparently shortened anteroposterior dimension (length) of the head compared to width." ; oboInOwl:hasAlternativeId "HP:0002258", "HP:0004479", "HP:0008512" ; oboInOwl:hasBroadSynonym "Broad cranium shape", "Broad head shape", "Broad skull shape", "Wide cranium shape", "Wide head shape", "Wide skull shape" ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:13649004", "UMLS:C0221356", "UMLS:C4072823", "UMLS:C4072824" ; oboInOwl:hasExactSynonym "Short and broad skull" ; oboInOwl:id "HP:0000248" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Cephalic index is the ratio of head width expressed as a percentage of head length. The normal range is 76-80.9%. Head length is measured between the glabella (the most prominent point on the frontal bone above the root of the nose) and the most prominent part of the occiput in the midline, using spreading calipers. Head width is measured between the most lateral points of the parietal bones on each side of the head, using spreading calipers. Cephalic index standards are derived from Caucasians and have limited relevance for other races and ethnicities. Current norms also have limited validity because of changes in infant sleeping position and consequent changes in head shape. New data should be developed. Brachycephaly is distinct from Flat occiput, but both can be present in the same individual and should be coded separately." ; rdfs:label "Brachycephaly" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000250 obo:IAO_0000115 "An abnormal increase of density of the bones making up the calvaria." ; oboInOwl:hasDbXref "UMLS:C1854834" ; oboInOwl:hasExactSynonym "Dense skull cap" ; oboInOwl:id "HP:0000250" ; a owl:Class ; rdfs:label "Dense calvaria" ; rdfs:subClassOf obo:HP_0002683, obo:HP_0004330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000252 obo:IAO_0000115 "Head circumference below 2 standard deviations below the mean for age and gender." ; oboInOwl:hasAlternativeId "HP:0001366", "HP:0005485", "HP:0005489", "HP:0005497" ; oboInOwl:hasBroadSynonym "Abnormally small head", "Decreased size of head", "Small head", "Small skull" ; oboInOwl:hasDbXref "Fyler:4310", "SNOMEDCT_US:271611007", "UMLS:C4551563" ; oboInOwl:hasExactSynonym "Abnormally small cranium", "Abnormally small skull", "Decreased circumference of cranium", "Decreased size of cranium", "Decreased size of skull", "Reduced head circumference", "Small head circumference", "small calvarium", "small cranium" ; oboInOwl:id "HP:0000252" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles, others by standard deviations. It is important to add an indication of how far below the normal standard the head circumference is if an accurate assessment of this can be made. Microcephaly is an absolute term. The term relative microcephaly can be used when the head size centile is less than the centile for height, for example, head size at the 3rd centile with height at the 75% for age and sex. On prenatal ultrasound, microcephaly is diagnosed if the head circumference or the biparietal diameter is more than three standard deviations below the mean. Microcephaly is divided into primary microcephaly, which is present at birth, and secondary microcephaly, which develops postnatally. The crucial difference between these groupings is that primary microcephaly is usually a static developmental anomaly, whereas secondary microcephaly indicates a progressive neurodegenerative condition" ; rdfs:label "Microcephaly" ; rdfs:subClassOf obo:HP_0007364, obo:HP_0040195 . obo:HP_0000253 obo:IAO_0000115 "Progressive microcephaly is diagnosed when the head circumference falls progressively behind age- and gender-dependent norms." ; oboInOwl:hasDbXref "UMLS:C1850456" ; oboInOwl:hasExactSynonym "Microcephaly, postnatal, progressive", "Microcephaly, progressive", "Progressively abnormally small cranium", "Progressively abnormally small skull" ; oboInOwl:id "HP:0000253" ; a owl:Class ; rdfs:label "Progressive microcephaly" ; rdfs:subClassOf obo:HP_0005484 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0000255 obo:IAO_0000115 "An acute form of sinusitis." ; oboInOwl:hasDbXref "SNOMEDCT_US:15805002", "UMLS:C0149512" ; oboInOwl:id "HP:0000255" ; a owl:Class ; rdfs:label "Acute sinusitis" ; rdfs:subClassOf obo:HP_0000246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000246 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000256 obo:IAO_0000115 "Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium." ; oboInOwl:hasAlternativeId "HP:0005491", "HP:0005496", "HP:0200135" ; oboInOwl:hasBroadSynonym "Big calvaria", "Big cranium", "Big head", "Big skull", "Increased size of head", "Large calvaria", "Large cranium", "Large skull" ; oboInOwl:hasDbXref "Fyler:4335", "UMLS:C4083076", "UMLS:C4255213", "UMLS:C4280663", "UMLS:C4280664" ; oboInOwl:hasExactSynonym "Increased size of cranium", "Increased size of skull", "Large head", "Large head circumference", "Macrocephalus", "Macrocrania", "Megacephaly" ; oboInOwl:id "HP:0000256" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Macrocephaly can be due to hydrocephalus (increased CFSF), megalencephaly (increased brain volume) or thickening of the skull. Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far above the normal standard the head circumference is if an accurate assessment of this can be made. Macrocephaly is an absolute term. The term relative macrocephaly can be used when the head size centile exceeds the centile for height, for example, head size at the 75th centile with height at the 5th centile for age and sex." ; rdfs:label "Macrocephaly" ; rdfs:subClassOf obo:HP_0040194 . obo:HP_0000260 obo:IAO_0000115 "Enlargement of the anterior fontanelle with respect to age-dependent norms." ; oboInOwl:hasDbXref "UMLS:C1866134" ; oboInOwl:hasExactSynonym "Large anterior fontanel", "Large anterior fontanelle", "Large open anterior fontanel", "Large open anterior fontanelle", "Wide anterior fontanelle", "Wide open anterior fontanelle", "Wider-than-typical soft spot of skull" ; oboInOwl:hasRelatedSynonym "Large anterior fontanels" ; oboInOwl:id "HP:0000260" ; a owl:Class ; rdfs:label "Wide anterior fontanel" ; rdfs:subClassOf obo:HP_0000236, obo:HP_0000239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000262 obo:IAO_0000115 "Tall head relative to width and length." ; oboInOwl:hasAlternativeId "HP:0001356" ; oboInOwl:hasBroadSynonym "Tall shaped head" ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:48069004", "UMLS:C0030044" ; oboInOwl:hasExactSynonym "Tall shaped cranium", "Tall shaped skull", "Tower cranium shape", "Tower skull shape", "Turricephalus" ; oboInOwl:id "HP:0000262" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Turricephaly is derived from the Latin word turris, meaning tall, and refers to a round, tall (tower-like) skull. This feature may have previously been considered to overlap with or include a tall forehead. Turricephaly is present when the head appears tall (subjective) and head length and width are reduced compared to normal age-related standards (objective). Head length is measured between the glabella (the most prominent point on the frontal bone above the root of the nose) and the most prominent part of the occiput in the midline, using spreading calipers. Head width is measured between the most lateral points of the parietal bones on each side of the head, using spreading calipers. The term acrocephaly (or oxycephaly) is used when there is turricephaly and the top of the skull assumes a cone shape." ; rdfs:label "Turricephaly" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0000263 obo:IAO_0000115 "Oxycephaly (from Greek oxus, sharp, and kephalos, head) refers to a conical or pointed shape of the skull." ; oboInOwl:hasDbXref "MSH:D003398" ; oboInOwl:hasRelatedSynonym "Acrocephaly" ; oboInOwl:id "HP:0000263" ; a owl:Class ; rdfs:label "Oxycephaly" ; rdfs:subClassOf obo:HP_0000262 . obo:HP_0000264 obo:IAO_0000115 "An abnormality of the mastoid process, which is the conical prominence projecting from the undersurface of the mastoid portion of the temporal bone." ; oboInOwl:hasDbXref "UMLS:C4025872" ; oboInOwl:hasExactSynonym "Abnormality of mastoid process of temporal bone", "Abnormality of the mastoid" ; oboInOwl:id "HP:0000264" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal mastoid morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011220 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000265 oboInOwl:hasDbXref "MSH:D008417", "SNOMEDCT_US:52404001", "UMLS:C0024904" ; oboInOwl:id "HP:0000265" ; a owl:Class ; rdfs:label "Mastoiditis" ; rdfs:subClassOf obo:HP_0000264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0011220 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000267 obo:IAO_0000115 "Asymmetry of the bones of the skull." ; oboInOwl:hasBroadSynonym "Asymmetry of head", "Uneven head shape" ; oboInOwl:hasDbXref "UMLS:C1860245", "UMLS:C4280258", "UMLS:C4280657", "UMLS:C4280658", "UMLS:C4280659", "UMLS:C4280660", "UMLS:C4280661", "UMLS:C4280662" ; oboInOwl:hasExactSynonym "Asymmetry of cranium", "Cranial vault asymmetry" ; oboInOwl:hasRelatedSynonym "Abnormality of cranial vault shape", "Abnormality of cranium shape", "Abnormality of head shape", "Malformation of cranial vault shape", "Malformation of cranium shape", "Malformation of head shape" ; oboInOwl:id "HP:0000267" ; a owl:Class ; rdfs:label "Cranial asymmetry" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000268 obo:IAO_0000115 "An abnormality of skull shape characterized by a increased anterior-posterior diameter, i.e., an increased antero-posterior dimension of the skull. Cephalic index less than 76%. Alternatively, an apparently increased antero-posterior length of the head compared to width. Often due to premature closure of the sagittal suture." ; oboInOwl:hasAlternativeId "HP:0000258", "HP:0005440" ; oboInOwl:hasBroadSynonym "Narrow cranium shape", "Narrow head shape", "Narrow skull shape", "Turridolichocephaly" ; oboInOwl:hasDbXref "SNOMEDCT_US:72239002", "UMLS:C0221358", "UMLS:C4280653", "UMLS:C4280654", "UMLS:C4280655", "UMLS:C4280656" ; oboInOwl:hasExactSynonym "Long, narrow head", "Tall and narrow skull" ; oboInOwl:hasNarrowSynonym "Large dolichocephalic skull" ; oboInOwl:id "HP:0000268" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Cephalic index is the ratio of head width expressed as a percentage of head length. The normal range is 76-80.9%. Head length is measured between the glabella (the most prominent point on the frontal bone above the root of the nose) and the most prominent part of the occiput in the midline, using spreading calipers. Head width is measured between the most lateral points of the parietal bones on each side of the head, using spreading calipers. Cephalic index standards are derived from Caucasians and have limited relevance for other races and ethnicities. Current norms have limited validity because of changes in infant sleeping position and consequent changes in head shape. New data should be developed. Dolichocephaly is distinct from Prominent occiput, but both can be present in the same individual and should be coded separately. Scaphocephaly is a subtype of dolichocephaly where the anterior and posterior aspects of the cranial vault are pointed (boat-shaped)." ; rdfs:label "Dolichocephaly" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000269 obo:IAO_0000115 "Increased convexity of the occiput (posterior part of the skull)." ; oboInOwl:hasAlternativeId "HP:0004489" ; oboInOwl:hasBroadSynonym "Prominent back of the head", "Prominent posterior head", "Protruding back of the head" ; oboInOwl:hasDbXref "UMLS:C1853737", "UMLS:C4280652" ; oboInOwl:hasExactSynonym "Prominent back of the skull", "Prominent posterior cranium", "Prominent posterior skull", "Protruding occiput" ; oboInOwl:id "HP:0000269" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Increased convexity of the occiput gives an appearance of prominence. There are no objective measures for convexity of the occiput, and evaluation depends heavily on the experience of the observer. This finding may or may not be accompanied by Dolichocephaly, but this should be coded separately." ; rdfs:label "Prominent occiput" ; rdfs:subClassOf obo:HP_0011217 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000270 obo:IAO_0000115 "Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age." ; oboInOwl:hasAlternativeId "HP:0002704", "HP:0003794" ; oboInOwl:hasDbXref "SNOMEDCT_US:82779003", "UMLS:C0277828" ; oboInOwl:hasExactSynonym "Broad late closing cranial sutures", "Delayed closure of fontanel", "Delayed closure of fontanelles", "Delayed closure of fontanels", "Delayed closure of the fontanelles", "Delayed cranial suture closure", "Delayed fontanel closure", "Delayed fontanelle closure", "Late closing fontanelles", "Late closure of fontanelle", "Late-closing fontanelle", "Open sutures" ; oboInOwl:id "HP:0000270" ; a owl:Class ; rdfs:label "Delayed cranial suture closure" ; rdfs:subClassOf obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002135 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000271 obo:IAO_0000115 "An abnormality of the face." ; oboInOwl:hasBroadSynonym "Abnormality of the countenance", "Abnormality of the physiognomy", "Abnormality of the visage", "Disorder of face" ; oboInOwl:hasDbXref "SNOMEDCT_US:118930001", "SNOMEDCT_US:32003007", "SNOMEDCT_US:398206004", "SNOMEDCT_US:398302004", "UMLS:C0266617", "UMLS:C1290857", "UMLS:C4025871" ; oboInOwl:hasExactSynonym "Abnormal face", "Abnormality of the face", "Facial abnormality" ; oboInOwl:hasNarrowSynonym "Disorder of the face" ; oboInOwl:hasRelatedSynonym "Anomaly of face", "Anomaly of the face", "Facial anomaly" ; oboInOwl:id "HP:0000271" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the face" ; rdfs:subClassOf obo:HP_0000234 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000272 obo:IAO_0000115 "Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation." ; oboInOwl:hasAlternativeId "HP:0000312", "HP:0000332", "HP:0004642", "HP:0004658", "HP:0004671", "HP:0005319", "HP:0005443", "HP:0005455", "HP:0100846" ; oboInOwl:hasDbXref "UMLS:C1858085", "UMLS:C4280651" ; oboInOwl:hasExactSynonym "Decreased size of malar bone", "Depressed malar region", "Flat cheekbone", "Malar hypoplasia", "Underdevelopment of malar bone", "Zygomatic flattening" ; oboInOwl:hasRelatedSynonym "Hypotrophic malar bone" ; oboInOwl:id "HP:0000272" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The malar process is the most medial and superior portion of the bony midface, articulating with the maxilla and temporal and sphenoid bones, contiguous with the lateral boundary of the nasal bridge. The term malar hypoplasia is no longer preferred because surface examination cannot distinguish hypoplasia from hypotrophy." ; rdfs:label "Malar flattening" ; rdfs:subClassOf obo:HP_0010668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002500 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000273 oboInOwl:hasDbXref "SNOMEDCT_US:37126005", "UMLS:C0234853" ; oboInOwl:hasExactSynonym "Facial grimacing" ; oboInOwl:id "HP:0000273" ; a owl:Class ; rdfs:label "Facial grimacing" ; rdfs:subClassOf obo:HP_0005324 . obo:HP_0000274 obo:IAO_0000115 "A face that is short and narrow." ; oboInOwl:hasDbXref "UMLS:C1855538" ; oboInOwl:hasExactSynonym "Facial hypoplasia", "Hypoplasia of face", "Microface", "Microfacies", "Short and narrow face", "Small face", "Small facies" ; oboInOwl:id "HP:0000274" ; a owl:Class ; rdfs:comment "This term represents a combination of two terms, short face and narrow face." ; rdfs:label "Small face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000275 obo:IAO_0000115 "Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective)." ; oboInOwl:hasAlternativeId "HP:0000318" ; oboInOwl:hasDbXref "UMLS:C1837463", "UMLS:C1849121" ; oboInOwl:hasExactSynonym "Decreased breadth of face", "Decreased horizontal dimension of face", "Decreased transverse dimension of face", "Decreased width of face", "Horizontal deficiency of face", "Horizontal hypoplasia of face", "Horizontal insufficiency of face", "Narrow face", "Narrow facies", "Thin facies", "Transverse deficiency of face", "Transverse hypoplasia of face", "Transverse insufficiency of face" ; oboInOwl:hasRelatedSynonym "Thin face" ; oboInOwl:id "HP:0000275" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Objective measurement of the upper facial width is made with spreading calipers. The tips of the calipers are passed over the zygomatic arches until the maximum width is determined. Objective measurement of the lower faces is made with spreading calipers, with the tips firmly pressed against the inferomedial surface of the angle of the mandible." ; rdfs:label "Narrow face" ; rdfs:subClassOf obo:HP_0000274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000276 obo:IAO_0000115 "Facial height (length) is more than 2 standard deviations above the mean (objective); or, an apparent increase in the height (length) of the face (subjective)." ; oboInOwl:hasAlternativeId "HP:0000334" ; oboInOwl:hasDbXref "UMLS:C1836047" ; oboInOwl:hasExactSynonym "Elongation of face", "Increased height of face", "Increased length of face", "Increased vertical dimension of face", "Long face", "Long facies", "Vertical Facial Excess", "Vertical elongation of face", "Vertical enlargement of face", "Vertical excess of face", "Vertical hyperplasia of face", "Vertical overgrowth of face" ; oboInOwl:id "HP:0000276" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Objective measurement of the face height is made with sliding calipers from the nasion, just above the depth of the nasal root, to the gnathion, the inferior border of the mandible, both in the midline. Note that long face is distinct from narrow face." ; rdfs:label "Long face" ; rdfs:subClassOf obo:HP_0100729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000277 obo:IAO_0000115 "Any abnormality of the mandible, the bone of the lower jaw." ; oboInOwl:hasAlternativeId "HP:0000209" ; oboInOwl:hasDbXref "UMLS:C4025870" ; oboInOwl:hasExactSynonym "Abnormality of the lower jaw bone", "Abnormality of the mandible" ; oboInOwl:hasNarrowSynonym "Anomaly of the mandible", "Deformity of the lower jaw bone", "Deformity of the mandible", "Malformation of the lower jaw bone", "Malformation of the mandible" ; oboInOwl:id "HP:0000277" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal mandible morphology" ; rdfs:subClassOf obo:HP_0030791 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000278 obo:IAO_0000115 "An abnormality in which the mandible is mislocalised posteriorly." ; oboInOwl:hasAlternativeId "HP:0002053", "HP:0002954" ; oboInOwl:hasDbXref "MSH:D063173", "UMLS:C3494422" ; oboInOwl:hasExactSynonym "Lower jaw retrognathia", "Receding chin", "Receding lower jaw", "Receding mandible", "Retrognathia of lower jaw", "Weak chin", "Weak jaw" ; oboInOwl:hasNarrowSynonym "Retrogenia" ; oboInOwl:id "HP:0000278" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retrognathia" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001922 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000280 obo:IAO_0000115 "Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues." ; oboInOwl:hasAlternativeId "HP:0000281", "HP:0004640" ; oboInOwl:hasDbXref "UMLS:C1845847", "UMLS:C4072825" ; oboInOwl:hasExactSynonym "Coarse face", "Coarse facial appearance", "Coarse facial features", "Coarse facies" ; oboInOwl:hasNarrowSynonym "Rounded and heavy facial features", "Thickened facial skin with coarse facial features" ; oboInOwl:id "HP:0000280" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Coarse facial features" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000700 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000282 oboInOwl:hasDbXref "SNOMEDCT_US:445088006", "UMLS:C0542571" ; oboInOwl:hasExactSynonym "Facial oedema", "Facial puffiness", "Facial swelling" ; oboInOwl:id "HP:0000282" ; a owl:Class ; rdfs:label "Facial edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0011799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000283 obo:IAO_0000115 "Bizygomatic (upper face) and bigonial (lower face) width greater than 2 standard deviations above the mean (objective); or an apparent increase in the width of the face (subjective)." ; oboInOwl:hasDbXref "UMLS:C1859680" ; oboInOwl:hasExactSynonym "Broad face", "Broad facies", "Horizontal excess of face", "Horizontal hyperplasia of face", "Increased breadth of face", "Increased horizontal dimension of face", "Increased transverse dimension of face", "Increased width of face", "Transverse excess of face", "Transverse hyperplasia of face", "Wide face", "Wide facies" ; oboInOwl:id "HP:0000283" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that broad face is distinct from round face." ; rdfs:label "Broad face" ; rdfs:subClassOf obo:HP_0100729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000284 obo:IAO_0100001 "HP:0000315" ; oboInOwl:id "HP:0000284" ; a owl:Class ; rdfs:label "obsolete Abnormality of the ocular region" ; owl:deprecated true . obo:HP_0000286 obo:IAO_0000115 "A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus." ; oboInOwl:hasAlternativeId "HP:0000624", "HP:0007930" ; oboInOwl:hasDbXref "UMLS:C0678230" ; oboInOwl:hasExactSynonym "Epicanthal fold", "Epicanthal folds", "Epicanthic folds", "Eye folds", "Palpebronasal fold", "Plica palpebronasalis", "Prominent eye folds" ; oboInOwl:id "HP:0000286" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In extreme cases, the skin fold can start as high as the eyebrow; this is called epicanthus superciliaris." ; rdfs:label "Epicanthus" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000287 obo:IAO_0000115 "An increased amount of subcutaneous fat tissue in the face." ; oboInOwl:hasDbXref "UMLS:C4025868", "UMLS:C4280649", "UMLS:C4280650" ; oboInOwl:hasExactSynonym "Increased amount of facial adipose tissue", "Increased amount of facial fat", "Increased volume of facial adipose tissue" ; oboInOwl:hasNarrowSynonym "Facial fat hyperplasia", "Facial fat hypertrophy", "Hyperplasia of facial adipose tissue", "Hypertrophy of facial adipose tissue" ; oboInOwl:id "HP:0000287" ; a owl:Class ; rdfs:label "Increased facial adipose tissue" ; rdfs:subClassOf obo:HP_0000291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000288 obo:IAO_0000115 "An abnormality of the philtrum." ; oboInOwl:hasAlternativeId "HP:0011216" ; oboInOwl:hasDbXref "UMLS:C1857045" ; oboInOwl:hasExactSynonym "Abnormal philtrum", "Abnormality of the infranasal depression", "Abnormality of the paralabial region" ; oboInOwl:id "HP:0000288" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The paralabial region is the region surrounding the lips and includes the philtrum." ; rdfs:label "Abnormality of the philtrum" ; rdfs:subClassOf obo:HP_0000177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000289 obo:IAO_0000115 "Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations above the mean, or alternatively, an apparently increased distance between the ridges of the philtrum." ; oboInOwl:hasDbXref "UMLS:C1854111" ; oboInOwl:hasExactSynonym "Increased breadth of philtrum", "Increased horizontal dimension of philtrum", "Increased transverse dimension of philtrum", "Increased width of philtrum", "Wide philtrum" ; oboInOwl:id "HP:0000289" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The mean width of the philtrum was found to be 7 mm in infants by Franz and Sokol [1971] and 9.7 mm in adults by Ward and Jamison [1991]. Measuring width of the philtrum is even more inaccurate than measuring length (vide supra). A broad philtrum may be associated with reduced ridge prominence or a shallow groove, a Smooth philtrum, which should be assessed and coded separately. It may be found with a broad nasal septum." ; rdfs:label "Broad philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000290 obo:IAO_0000115 "An anomaly of the forehead." ; oboInOwl:hasDbXref "UMLS:C4025867" ; oboInOwl:hasExactSynonym "Abnormality of the forehead", "Abnormality of the frontal region of the face" ; oboInOwl:hasNarrowSynonym "Anomaly of the forehead", "Deformity of the forehead", "Malformation of the forehead" ; oboInOwl:id "HP:0000290" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the forehead" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000291 oboInOwl:hasDbXref "UMLS:C4025866" ; oboInOwl:hasExactSynonym "Abnormality of facial fat" ; oboInOwl:hasNarrowSynonym "Deformity of facial adipose tissue", "Malformation of facial adipose tissue" ; oboInOwl:id "HP:0000291" ; a owl:Class ; rdfs:label "Abnormality of facial adipose tissue" ; rdfs:subClassOf obo:HP_0009124, obo:HP_0011799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000292 obo:IAO_0000115 "Loss of normal subcutaneous fat tissue in the face." ; oboInOwl:hasDbXref "UMLS:C1837767" ; oboInOwl:hasExactSynonym "Decreased amount of facial adipose tissue", "Decreased amount of facial fat", "Decreased volume of facial adipose tissue", "Loss of facial fat", "Loss of facial subcutaneous adipose tissue", "Loss of subcutaneous adipose tissue from face" ; oboInOwl:id "HP:0000292" ; a owl:Class ; rdfs:label "Loss of facial adipose tissue" ; rdfs:subClassOf obo:HP_0000291, obo:HP_0008887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000293 obo:IAO_0000115 "Increased prominence or roundness of soft tissues between zygomata and mandible." ; oboInOwl:hasAlternativeId "HP:0002262", "HP:0004427" ; oboInOwl:hasDbXref "UMLS:C1866231", "UMLS:C2748653", "UMLS:C3806443", "UMLS:C4280647", "UMLS:C4280648" ; oboInOwl:hasExactSynonym "Apple cheeks", "Big cheeks", "Full cheeks", "Increased size of cheeks", "Large cheeks" ; oboInOwl:hasRelatedSynonym "Chubby cheeks", "Hyperplasia of cheeks", "Hypertrophy of cheeks", "Puffy cheeks" ; oboInOwl:id "HP:0000293" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Full cheeks" ; rdfs:subClassOf obo:HP_0004426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000294 obo:IAO_0000115 "Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella." ; oboInOwl:hasDbXref "UMLS:C1842366" ; oboInOwl:hasExactSynonym "Low frontal hairline", "Low-set frontal hairline" ; oboInOwl:id "HP:0000294" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature gives the appearance of a short forehead. It is distinct from hirsutism of the forehead. In the latter, orientation of hair growth is lateral and texture and density of hair differs from scalp hair." ; rdfs:label "Low anterior hairline" ; rdfs:subClassOf obo:HP_0000599 . obo:HP_0000295 obo:IAO_0000115 "A characteristic facial appearance with a round facial form, full cheeks, a short nose, and a relatively small chin." ; oboInOwl:hasDbXref "UMLS:C1856361" ; oboInOwl:hasExactSynonym "Doll-like facial appearance" ; oboInOwl:id "HP:0000295" ; a owl:Class ; rdfs:comment "This term represents a bundle of phenotypic features and is kept for historical reasons. It is preferable to annotate the individual clinical findings precisely." ; rdfs:label "Doll-like facies" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0000297 obo:IAO_0000115 "Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve)." ; oboInOwl:hasDbXref "UMLS:C1845251", "UMLS:C4280646" ; oboInOwl:hasExactSynonym "Decreased facial muscle tone", "Hypotonic facies", "Low facial muscle tone", "Reduced facial muscle tone" ; oboInOwl:hasNarrowSynonym "Atony of facial musculature" ; oboInOwl:id "HP:0000297" ; a owl:Class ; rdfs:label "Facial hypotonia" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0001252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001252 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000298 obo:IAO_0000115 "A lack of facial expression often with staring eyes and a slightly open mouth." ; oboInOwl:hasDbXref "SNOMEDCT_US:103606006", "UMLS:C0424448" ; oboInOwl:hasExactSynonym "Amimia", "Expressionless face", "Lack of facial expression", "Mask-like facial appearance", "Masklike facies" ; oboInOwl:id "HP:0000298" ; a owl:Class ; rdfs:comment "Mask-like facies can be seen in many neurological disorders such as Parkinsonism and myotonic dystrophy." ; rdfs:label "Mask-like facies" ; rdfs:subClassOf obo:HP_0004673 . obo:HP_0000300 obo:IAO_0000115 "A face with a rounded and slightly elongated outline." ; oboInOwl:hasDbXref "UMLS:C1849025" ; oboInOwl:hasExactSynonym "Oval face", "Oval facial shape", "Oval facies" ; oboInOwl:id "HP:0000300" ; a owl:Class ; rdfs:label "Oval face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001891 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000301 obo:IAO_0000115 "An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve)." ; oboInOwl:hasDbXref "UMLS:C4025865" ; oboInOwl:hasExactSynonym "Abnormality of facial muscles", "Facial muscle issue" ; oboInOwl:id "HP:0000301" ; a owl:Class ; rdfs:comment "Facial muscles control facial expression and are innervated by the seventh cranial nerve. Facial muscles around the eye are responsible for eye blink and eyelid closure." ; rdfs:label "Abnormality of facial musculature" ; rdfs:subClassOf obo:HP_0011799, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000303 obo:IAO_0000115 "Abnormal prominence of the chin related to increased length of the mandible." ; oboInOwl:hasAlternativeId "HP:0000251", "HP:0000279", "HP:0000328", "HP:0002051", "HP:0004648", "HP:0004656", "HP:0008514" ; oboInOwl:hasBroadSynonym "Hypertrophy of lower jaw", "Hypertrophy of mandible" ; oboInOwl:hasDbXref "MSH:D008313", "SNOMEDCT_US:109504005", "SNOMEDCT_US:22810007", "UMLS:C0302501", "UMLS:C0399526", "UMLS:C2227134", "UMLS:C4280644", "UMLS:C4280645" ; oboInOwl:hasExactSynonym "Big lower jaw", "Big mandible", "Enlarged mandible", "Enlargement of mandible", "Hyperplasia of lower jaw", "Increased projection of lower jaw", "Increased projection of mandible", "Increased size of lower jaw", "Large lower jaw", "Large mandible", "Lower jaw excess", "Lower jaw hyperplasia", "Macromandible", "Mandible prognathism", "Mandibular excess", "Mandibular hyperplasia", "Mandibular macrognathia", "Mandibular prognathism", "Prognathia", "Prognathism", "Prominent chin", "Prominent jaw", "Prominent lower jaw", "Prominent mandible", "Relative mandibular prognathism" ; oboInOwl:hasRelatedSynonym "Increased size of mandible" ; oboInOwl:id "HP:0000303" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Mandibular prognathia" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000306 obo:IAO_0000115 "An abnormality of the chin, i.e., of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw." ; oboInOwl:hasDbXref "UMLS:C4025864" ; oboInOwl:hasExactSynonym "Abnormality of the chin" ; oboInOwl:hasNarrowSynonym "Abnormality of the menton", "Anomaly of the chin", "Deformity of the chin", "Malformation of the chin" ; oboInOwl:id "HP:0000306" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the chin" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000307 obo:IAO_0000115 "A marked tapering of the lower face to the chin." ; oboInOwl:hasAlternativeId "HP:0005330" ; oboInOwl:hasDbXref "UMLS:C1844505" ; oboInOwl:hasExactSynonym "Pointed chin", "Pointed mention region", "Pointy chin", "Small pointed chin", "Witch's chin" ; oboInOwl:id "HP:0000307" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The two rami of the mandible meet at an acute angle." ; rdfs:label "Pointed chin" ; rdfs:subClassOf obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000944 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000308 obo:IAO_0000115 "A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly." ; oboInOwl:hasDbXref "UMLS:C1839546" ; oboInOwl:hasExactSynonym "Retromicrognathia", "Small retruded chin" ; oboInOwl:id "HP:0000308" ; a owl:Class ; rdfs:label "Microretrognathia" ; rdfs:subClassOf obo:HP_0000278, obo:HP_0000347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000347 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001922 ] ) ] ] . obo:HP_0000309 obo:IAO_0000115 "An anomaly of the midface, which is a region and not an anatomical term. It extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base. It is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region. Traditionally, the nose and premaxilla are not included in the midface." ; oboInOwl:hasAlternativeId "HP:0430026" ; oboInOwl:hasDbXref "UMLS:C4021811" ; oboInOwl:hasExactSynonym "Abnormal morphology of the midface", "Abnormality of the midface", "Anomaly of the midface" ; oboInOwl:hasNarrowSynonym "Deformity of the midface", "Malformation of the midface" ; oboInOwl:id "HP:0000309" ; a owl:Class ; rdfs:label "Abnormal midface morphology" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000311 obo:IAO_0000115 "The facial appearance is more circular than usual as viewed from the front." ; oboInOwl:hasAlternativeId "HP:0000304", "HP:0004653" ; oboInOwl:hasBroadSynonym "Round, full face" ; oboInOwl:hasDbXref "UMLS:C0239479", "UMLS:C1856468" ; oboInOwl:hasExactSynonym "Circular face", "Round face", "Round facial appearance", "Round facial shape", "Round facies" ; oboInOwl:id "HP:0000311" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Round face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000315 oboInOwl:hasAlternativeId "HP:0000284" ; oboInOwl:hasDbXref "UMLS:C4025863" ; oboInOwl:hasExactSynonym "Abnormality of the eye region", "Abnormality of the region around the eyes" ; oboInOwl:hasNarrowSynonym "Anomaly of the orbital region of the face", "Deformity of the orbital region of the face", "Malformation of the orbital region of the face" ; oboInOwl:id "HP:0000315" ; a owl:Class ; rdfs:label "Abnormality of the orbital region" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000316 obo:IAO_0000115 "Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes)." ; oboInOwl:hasAlternativeId "HP:0000578", "HP:0002001", "HP:0004657", "HP:0007871" ; oboInOwl:hasDbXref "MSH:D006972", "SNOMEDCT_US:194021007", "SNOMEDCT_US:22006008", "UMLS:C0020534" ; oboInOwl:hasExactSynonym "Excessive orbital separation", "Increased distance between eye sockets", "Increased distance between eyes", "Increased interpupillary distance", "Ocular hypertelorism", "Wide-set eyes", "Widely spaced eyes", "Widened interpupillary distance" ; oboInOwl:id "HP:0000316" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypertelorism" ; rdfs:subClassOf obo:HP_0100886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010222 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000317 obo:IAO_0000115 "Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." ; oboInOwl:hasAlternativeId "HP:0004651" ; oboInOwl:hasDbXref "MSH:D005155", "SNOMEDCT_US:1070000", "UMLS:C0270871" ; oboInOwl:hasExactSynonym "Involuntary facial contraction", "Involuntary facial quivering" ; oboInOwl:id "HP:0000317" ; a owl:Class ; rdfs:comment "Facial myokymia may be caused by a plaque of multiple sclerosis or have other causes." ; rdfs:label "Facial myokymia" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0002411 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000319 obo:IAO_0000115 "Flat skin surface, with no ridge formation in the central region of the upper lip between the nasal base and upper vermilion border." ; oboInOwl:hasAlternativeId "HP:0000299", "HP:0000323", "HP:0004663" ; oboInOwl:hasDbXref "UMLS:C1142533" ; oboInOwl:hasExactSynonym "Decreased depth of philtrum", "Flat philtrum", "Indistinct philtrum", "Philtrum, smooth", "Shallow philtrum", "Simple philtrum" ; oboInOwl:id "HP:0000319" ; a owl:Class ; rdfs:comment "There is a spectrum of this finding from total absence of the philtral ridges to a some prominence of the ridges. The central groove varies from absent to shallow. Normal values for the frequency of smooth philtrum are available. Grading of the smoothness of the philtrum, used in the assessment of Fetal Alcohol Syndrome, has been developed. This finding is greatly influenced by the facial expression, and care should be taken to evaluate the philtrum when the face is in a neutral position. A smooth philtrum can be associated with a Long philtrum. However, the two findings should be coded separately." ; rdfs:label "Smooth philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000320 oboInOwl:hasDbXref "UMLS:C1837758" ; oboInOwl:hasExactSynonym "Bird-like facial appearance" ; oboInOwl:id "HP:0000320" ; a owl:Class ; rdfs:label "Bird-like facies" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0000321 obo:IAO_0000115 "Facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance." ; oboInOwl:hasDbXref "UMLS:C1832127" ; oboInOwl:hasExactSynonym "Square face", "Square facial shape", "Square facies" ; oboInOwl:id "HP:0000321" ; a owl:Class ; rdfs:label "Square face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000413 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000322 obo:IAO_0000115 "Distance between nasal base and midline upper lip vermilion border more than 2 SD below the mean. Alternatively, an apparently decreased distance between nasal base and midline upper lip vermilion border." ; oboInOwl:hasAlternativeId "HP:0200090" ; oboInOwl:hasDbXref "UMLS:C1861324" ; oboInOwl:hasExactSynonym "Decreased height of philtrum", "Decreased length of philtrum", "Decreased vertical dimension of philtrum", "Vertical hypoplasia of philtrum" ; oboInOwl:id "HP:0000322" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000324 obo:IAO_0000115 "An abnormal difference between the left and right sides of the face." ; oboInOwl:hasAlternativeId "HP:0003775" ; oboInOwl:hasDbXref "MSH:D005146", "SNOMEDCT_US:15253005", "UMLS:C1306710" ; oboInOwl:hasExactSynonym "Asymmetric facies", "Asymmetry of face", "Asymmetry of right and left side of face", "Crooked face", "Facial asymmetry", "Unsymmetrical face" ; oboInOwl:hasRelatedSynonym "Unbalanced face", "Unequal sides of face", "Uneven face", "Uneven sides of face" ; oboInOwl:id "HP:0000324" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Facial asymmetry" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000325 obo:IAO_0000115 "Facial contour, as viewed from the front, triangular in shape, with breadth at the temples and tapering to a narrow chin." ; oboInOwl:hasAlternativeId "HP:0004645", "HP:0004662", "HP:0004668" ; oboInOwl:hasDbXref "UMLS:C1835884" ; oboInOwl:hasExactSynonym "Face with broad temples and narrow chin", "Triangular face", "Triangular facial shape", "Triangular facies" ; oboInOwl:id "HP:0000325" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Triangular face" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0000326 obo:IAO_0000115 "An abnormality of the Maxilla (upper jaw bone)." ; oboInOwl:hasDbXref "UMLS:C4025862" ; oboInOwl:hasExactSynonym "Abnormality of the maxilla", "Abnormality of the upper jaw bone", "Abnormality of the upper jaw bones" ; oboInOwl:hasNarrowSynonym "Anomaly of the maxilla", "Deformity of the maxilla", "Deformity of the upper jaw bones", "Malformation of the maxilla", "Malformation of the upper jaw bones" ; oboInOwl:id "HP:0000326" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal maxilla morphology" ; rdfs:subClassOf obo:HP_0030791 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000327 obo:IAO_0000115 "Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region." ; oboInOwl:hasAlternativeId "HP:0004644" ; oboInOwl:hasBroadSynonym "Deficiency of upper jaw bones" ; oboInOwl:hasDbXref "UMLS:C0240310", "UMLS:C4082243", "UMLS:C4280640", "UMLS:C4280641", "UMLS:C4280642", "UMLS:C4280643" ; oboInOwl:hasExactSynonym "Decreased size of maxilla", "Decreased size of upper jaw", "Hypoplasia of upper jaw bones", "Hypoplastic maxillary bones", "Maxillary deficiency", "Maxillary hypoplasia", "Maxillary micrognathia", "Maxillary retrognathia", "Maxillary retrusion", "Micromaxilla", "Small maxilla", "Small upper jaw", "Small upper jaw bones", "Upper jaw deficiency", "Upper jaw retrusion" ; oboInOwl:hasNarrowSynonym "Decreased projection of maxilla", "Decreased projection of upper jaw" ; oboInOwl:hasRelatedSynonym "Hypotrophic maxilla", "Hypotrophic upper jaw bones", "Retrognathia of upper jaw", "Retrusion of upper jaw bones" ; oboInOwl:id "HP:0000327" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the maxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000329 obo:IAO_0000115 "Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face." ; oboInOwl:hasDbXref "UMLS:C1861443" ; oboInOwl:hasExactSynonym "Facial hemangiomata" ; oboInOwl:id "HP:0000329" ; a owl:Class ; rdfs:label "Facial hemangioma" ; rdfs:subClassOf obo:HP_0001028, obo:HP_0011799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001028 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000331 obo:IAO_0000115 "Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin." ; oboInOwl:hasDbXref "SNOMEDCT_US:699439001", "UMLS:C1839323", "UMLS:C3697248" ; oboInOwl:hasExactSynonym "Decreased height of chin", "Short chin", "Short lower third of face", "Vertical deficiency of chin", "Vertical hypoplasia of chin" ; oboInOwl:hasRelatedSynonym "Small chin" ; oboInOwl:id "HP:0000331" ; a owl:Class ; rdfs:comment "The term \"micrognathia\" should be used when the chin is both short (vertical dimension) and narrow (horizontal dimension)." ; rdfs:label "Short chin" ; rdfs:subClassOf obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000336 obo:IAO_0000115 "Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones." ; oboInOwl:hasDbXref "UMLS:C1842060", "UMLS:C4280636", "UMLS:C4280637", "UMLS:C4280638", "UMLS:C4280639" ; oboInOwl:hasExactSynonym "Prominent brow", "Prominent supraorbital margins", "Prominent supraorbital ridge", "Protruding supraorbital ridge", "Supraorbital hyperostosis" ; oboInOwl:hasNarrowSynonym "Hyperplasia of supraorbital margins", "Hyperplasia of supraorbital ridge", "Hypertrophy of supraorbital margins", "Hypertrophy of supraorbital ridge" ; oboInOwl:id "HP:0000336" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent supraorbital ridges" ; rdfs:subClassOf obo:HP_0100538 . obo:HP_0000337 obo:IAO_0000115 "Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead." ; oboInOwl:hasAlternativeId "HP:0000352", "HP:0000354" ; oboInOwl:hasDbXref "UMLS:C1849089" ; oboInOwl:hasExactSynonym "Bitemporal widening", "Broad forehead", "Increased bitemporal dimension", "Increased bitemporal width", "Increased width of the forehead", "Intertemporal widening", "Wide forehead" ; oboInOwl:id "HP:0000337" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Frontotemporalis is a point lateral to the vertical component of the supraorbital ridge, where there is a hollowing. Spreading caliper tips are placed in the deepest part of that hollow. Note that this term should not be confused with prominent forehead." ; rdfs:label "Broad forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000338 obo:IAO_0000115 "A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation." ; oboInOwl:hasAlternativeId "HP:0008769" ; oboInOwl:hasDbXref "SNOMEDCT_US:248149005", "UMLS:C0813217", "UMLS:C1862474", "UMLS:C4280635" ; oboInOwl:hasExactSynonym "Dull facial expression", "Hypomimia" ; oboInOwl:hasRelatedSynonym "Decreased facial expressions", "Decreased facial muscle movement" ; oboInOwl:id "HP:0000338" ; a owl:Class ; rdfs:comment "The movement and position of facial muscles are often interpreted as expressing emotions. Individuals with hypomimic face may be perceived as expressing less emotion than normal." ; rdfs:label "Hypomimic face" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0004673 . obo:HP_0000339 obo:IAO_0000115 "Coarse facial features reminiscent of those of a boxer." ; oboInOwl:hasDbXref "UMLS:C1846011" ; oboInOwl:hasExactSynonym "Boxer-like facial appearance", "Pugilistic facial appearance" ; oboInOwl:id "HP:0000339" ; a owl:Class ; rdfs:label "Pugilistic facies" ; rdfs:subClassOf obo:HP_0000280 . obo:HP_0000340 obo:IAO_0000115 "Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view." ; oboInOwl:hasAlternativeId "HP:0000351", "HP:0004480", "HP:0008493", "HP:0008500" ; oboInOwl:hasDbXref "UMLS:C1857679" ; oboInOwl:hasExactSynonym "Inclined forehead", "Posteriorly sloping forehead", "Receding forehead", "Sloping forehead" ; oboInOwl:id "HP:0000340" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Measurement requires an angle meter, inclined on the anterior surface of the forehead, in the midline, along a line connecting the hairline to the glabella, compared to the vertical." ; rdfs:label "Sloping forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001481 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000341 obo:IAO_0000115 "Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective)." ; oboInOwl:hasAlternativeId "HP:0000314", "HP:0004674", "HP:0004677" ; oboInOwl:hasDbXref "UMLS:C1839758" ; oboInOwl:hasExactSynonym "Bitemporal narrowing", "Bitemporal narrowness", "Bitemporal skull narrowing", "Decreased width of the forehead", "Intertemporal narrowing", "Narrow bitemporal diameter", "Narrow bitemporal width", "Narrow forehead", "Temporal narrowness" ; oboInOwl:id "HP:0000341" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A reduced distance between the temporal regions (temples) on each side of the head to one another. Frontotemporalis is a point lateral to the vertical component of the supraorbital ridge, where there is a hollowing. Spreading caliper tips are placed in the deepest part of that hollow." ; rdfs:label "Narrow forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000343 obo:IAO_0000115 "Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border." ; oboInOwl:hasDbXref "UMLS:C1865014" ; oboInOwl:hasExactSynonym "Elongated philtrum", "Increased height of philtrum", "Increased length of philtrum", "Increased vertical dimension of philtrum", "Vertical hyperplasia of philtrum" ; oboInOwl:id "HP:0000343" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000346 obo:IAO_0000115 "An abnormality of facial morphology characterized by a small mouth opening and constant contraction of the lips as if the patient were whistling." ; oboInOwl:hasDbXref "UMLS:C1848473" ; oboInOwl:hasExactSynonym "Whistling appearance", "Whistling facial appearance" ; oboInOwl:id "HP:0000346" ; a owl:Class ; rdfs:label "Whistling appearance" ; rdfs:subClassOf obo:HP_0000205 . obo:HP_0000347 obo:IAO_0000115 "Developmental hypoplasia of the mandible." ; oboInOwl:hasAlternativeId "HP:0000210", "HP:0000330", "HP:0000345", "HP:0002005", "HP:0002674", "HP:0004669", "HP:0005460", "HP:0005470" ; oboInOwl:hasBroadSynonym "Deficiency of lower jaw" ; oboInOwl:hasDbXref "Fyler:4163", "MSH:D008844", "SNOMEDCT_US:32958008", "UMLS:C0025990", "UMLS:C0240295", "UMLS:C1857130" ; oboInOwl:hasExactSynonym "Decreased size of lower jaw", "Decreased size of mandible", "Hypoplasia of lower jaw", "Hypoplasia of mandible", "Hypoplastic mandible", "Hypoplastic mandible condyle", "Hypotrophic lower jaw", "Hypotrophic mandible", "Little lower jaw", "Little mandible", "Lower jaw deficiency", "Lower jaw hypoplasia", "Lower jaw retrusion", "Mandibular deficiency", "Mandibular hypoplasia", "Mandibular micrognathia", "Mandibular retrognathia", "Mandibular retrusion", "Micrognathia of lower jaw", "Micromandible", "Robin mandible", "Severe hypoplasia of mandible", "Small jaw", "Small lower jaw", "Small mandible", "Underdevelopment of lower jaw", "Underdevelopment of mandible" ; oboInOwl:hasNarrowSynonym "Decreased projection of lower jaw", "Decreased projection of mandible" ; oboInOwl:hasRelatedSynonym "Retrusion of lower jaw" ; oboInOwl:id "HP:0000347" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Mandibular hypoplasia, also known as micrognathia, is a term that describes an abnormally small lower jaw." ; rdfs:label "Micrognathia" ; rdfs:subClassOf obo:HP_0009118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000348 obo:IAO_0000115 "An abnormally increased height of the forehead." ; oboInOwl:hasAlternativeId "HP:0000342" ; oboInOwl:hasDbXref "UMLS:C0239676", "UMLS:C2677762" ; oboInOwl:hasExactSynonym "High forehead" ; oboInOwl:hasRelatedSynonym "Tall forehead" ; oboInOwl:id "HP:0000348" ; a owl:Class ; rdfs:label "High forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000349 obo:IAO_0000115 "Frontal hairline with bilateral arcs to a low point in the midline of the forehead." ; oboInOwl:hasAlternativeId "HP:0004544" ; oboInOwl:hasDbXref "UMLS:C1853486" ; oboInOwl:hasExactSynonym "Hairline peak", "Hairline point", "Pointed frontal hairline", "Pointed hairline at front of head", "V-shaped frontal hairline", "Widow's peak" ; oboInOwl:id "HP:0000349" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The hair may need to be pulled back to recognize this feature. Historically, English widows in the 18th century wore a black hat, triangular in shape, with a point facing forward in the midline." ; rdfs:label "Widow's peak" ; rdfs:subClassOf obo:HP_0009890 . obo:HP_0000350 obo:IAO_0000115 "The presence of a forehead that is abnormally small." ; oboInOwl:hasDbXref "UMLS:C1845250", "UMLS:C4280633", "UMLS:C4280634" ; oboInOwl:hasExactSynonym "Decreased size of forehead", "Decreased size of frontal region of face", "Small forehead" ; oboInOwl:hasNarrowSynonym "Hypoplasia of forehead", "Hypotrophic forehead" ; oboInOwl:id "HP:0000350" ; a owl:Class ; rdfs:label "Small forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000356 obo:IAO_0000115 "An abnormality of the external ear." ; oboInOwl:hasAlternativeId "HP:0001752" ; oboInOwl:hasDbXref "SNOMEDCT_US:275259005", "UMLS:C0266589", "UMLS:C1846460" ; oboInOwl:hasExactSynonym "Abnormal pinnae", "Abnormality of the auricle", "Abnormality of the external ear", "Abnormality of the outer ear", "Ear anomalies", "External ear malformations", "Malformed pinnae", "Outer ear abnormality" ; oboInOwl:id "HP:0000356" ; a owl:Class ; rdfs:label "Abnormality of the outer ear" ; rdfs:subClassOf obo:HP_0031703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000357 obo:IAO_0000115 "Abnormal location of the ear." ; oboInOwl:hasDbXref "UMLS:C4021810" ; oboInOwl:hasExactSynonym "Abnormal location of ears", "External ear position defect" ; oboInOwl:id "HP:0000357" ; a owl:Class ; rdfs:label "Abnormal location of ears" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000358 obo:IAO_0000115 "A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front)." ; oboInOwl:hasAlternativeId "HP:0008535" ; oboInOwl:hasDbXref "SNOMEDCT_US:253251006", "UMLS:C0431478" ; oboInOwl:hasExactSynonym "Ear, posterior angulation, increased", "Ears rotated toward back of head", "Posteriorly angulated ears", "Posteriorly rotated", "Posteriorly rotated auricles", "Posteriorly-angulated ears", "Posteriorly-rotated ears" ; oboInOwl:id "HP:0000358" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Angle formed by the line perpendicular to the Frankfurt plane and the medial longitudinal axis of the ear (the two most remote points of the ear) greater than two standard deviations above the mean for age." ; rdfs:label "Posteriorly rotated ears" ; rdfs:subClassOf obo:HP_0000357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000359 obo:IAO_0000115 "An abnormality of the inner ear." ; oboInOwl:hasDbXref "UMLS:C4021809" ; oboInOwl:hasExactSynonym "Abnormality of the inner ear", "Inner ear abnormality" ; oboInOwl:id "HP:0000359" ; a owl:Class ; rdfs:label "Abnormality of the inner ear" ; rdfs:subClassOf obo:HP_0031703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001846 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000360 obo:IAO_0000115 "Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation." ; oboInOwl:hasDbXref "MSH:D014012", "SNOMEDCT_US:162349004", "SNOMEDCT_US:162352007", "SNOMEDCT_US:60862001", "UMLS:C0040264" ; oboInOwl:hasExactSynonym "Ringing in ears", "Ringing in the ears" ; oboInOwl:id "HP:0000360" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Tinnitus" ; rdfs:subClassOf obo:HP_0000364 . obo:HP_0000361 obo:IAO_0100001 "HP:0008629" ; oboInOwl:id "HP:0000361" ; a owl:Class ; rdfs:label "obsolete Pulsatile tinnitus (tympanic paraganglioma)" ; owl:deprecated true . obo:HP_0000362 obo:IAO_0000115 "In otosclerosis, a callus of bone accumulates on the stapes creating a partial fixation. This limits the movement of the stapes bone, which results in hearing loss." ; oboInOwl:hasDbXref "MSH:D010040", "SNOMEDCT_US:11543004", "UMLS:C0029899" ; oboInOwl:id "HP:0000362" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Otosclerosis cannot be seen on an office examination. The audiogram indicates a conductive type of hearing loss. Testing of the stapedial reflexes indicates limited or no movement of the bones of hearing." ; rdfs:label "Otosclerosis" ; rdfs:subClassOf obo:HP_0008628 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001839 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000363 obo:IAO_0000115 "An abnormality of the lobule of pinna." ; oboInOwl:hasDbXref "UMLS:C4021808" ; oboInOwl:hasExactSynonym "Abnormal earlobe", "Abnormal lobe of ear", "Abnormality of auricular lobule", "Abnormality of ear lobe", "Abnormality of earlobe", "Abnormality of lobulus auriculae" ; oboInOwl:id "HP:0000363" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal earlobe morphology" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001847 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000364 obo:IAO_0000115 "An abnormality of the sensory perception of sound." ; oboInOwl:hasDbXref "UMLS:C4025860" ; oboInOwl:hasExactSynonym "Abnormal hearing", "Hearing abnormality" ; oboInOwl:id "HP:0000364" ; a owl:Class ; rdfs:comment "According to the World Health Organization, deafness refers to the complete loss of hearing ability in one or two ears. Hearing impairment refers to both complete and partial loss of the ability to hear." ; rdfs:label "Hearing abnormality" ; rdfs:subClassOf obo:HP_0031704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0007605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000365 obo:IAO_0000115 "A decreased magnitude of the sensory perception of sound." ; oboInOwl:hasAlternativeId "HP:0000404", "HP:0001728", "HP:0001729", "HP:0001754", "HP:0008560", "HP:0008563" ; oboInOwl:hasDbXref "Fyler:4868", "MSH:D003638", "MSH:D034381", "SNOMEDCT_US:103276001", "SNOMEDCT_US:15188001", "SNOMEDCT_US:343087000", "SNOMEDCT_US:95828007", "UMLS:C0011053", "UMLS:C0018772", "UMLS:C0339789", "UMLS:C1384666" ; oboInOwl:hasExactSynonym "Deafness", "Hearing defect", "Hearing impairment", "Hypacusis" ; oboInOwl:hasRelatedSynonym "Hearing loss", "Hypoacusis" ; oboInOwl:id "HP:0000365" ; a owl:Class ; rdfs:comment "Hearing loss can be categorized by which part of the auditory system is damaged, as conductive hearing loss, sensorineural hearing loss, and mixed hearing loss. Another axis of classification uses the degree of hearing impairment. The degree of hearing loss is computed by using a three frequency average taken at 500 Hz, 1,000 Hz and 2,000 Hz. The average of these three frequencies is called the Pure Tone Average (PTA). 0-20 dB is considered normal, 21-40 dB mild loss, 41-60 dB moderate loss, 61-70 dB moderately severe loss,71-90 dB severe loss, and greater than 90 dB profound loss. Note that the word deafness is occasionally used to describe partial hearing loss. The World Health Organization uses the word deafness to refer to complete loss of the ability to hear, and hearing impairment to refer to any degree of reduced hearing." ; rdfs:label "Hearing impairment" ; rdfs:subClassOf obo:HP_0000364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000366 obo:IAO_0000115 "An abnormality of the nose." ; oboInOwl:hasDbXref "SNOMEDCT_US:128274005", "SNOMEDCT_US:72089000", "UMLS:C0240547", "UMLS:C0265736", "UMLS:C2235909" ; oboInOwl:hasExactSynonym "Abnormality of the nose", "Anomaly of the nose", "Nasal abnormality", "Nasal anomaly" ; oboInOwl:hasNarrowSynonym "Deformity of the nose", "Malformation of the nose", "Nasal deformity", "Nasal malformation" ; oboInOwl:id "HP:0000366" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the nose" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000368 obo:IAO_0000115 "Ears that are low-set and posteriorly rotated." ; oboInOwl:hasDbXref "UMLS:C1857486" ; oboInOwl:hasExactSynonym "Low-set posteriorly rotated ears" ; oboInOwl:id "HP:0000368" ; a owl:Class ; rdfs:comment "This bundled term is left for convenience because of its common use in the literature. It is preferable to code each feature separately." ; rdfs:label "Low-set, posteriorly rotated ears" ; rdfs:subClassOf obo:HP_0000358, obo:HP_0000369 . obo:HP_0000369 obo:IAO_0000115 "Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear." ; oboInOwl:hasDbXref "SNOMEDCT_US:95515009", "UMLS:C0239234" ; oboInOwl:hasExactSynonym "Low set ears", "Low-set ears", "Low-set pinnae", "Lowset ears", "Melotia" ; oboInOwl:id "HP:0000369" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Low-set ears" ; rdfs:subClassOf obo:HP_0000357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001476 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000370 obo:IAO_0000115 "An abnormality of the middle ear." ; oboInOwl:hasDbXref "UMLS:C1861141" ; oboInOwl:hasExactSynonym "Middle ear abnormalities", "Middle ear abnormality" ; oboInOwl:id "HP:0000370" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the middle ear" ; rdfs:subClassOf obo:HP_0031703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000371 obo:IAO_0000115 "Acute otitis media is a short and generally painful infection of the middle ear." ; oboInOwl:hasDbXref "SNOMEDCT_US:3110003", "UMLS:C0271429" ; oboInOwl:hasExactSynonym "Acute middle ear infection" ; oboInOwl:id "HP:0000371" ; a owl:Class ; rdfs:label "Acute otitis media" ; rdfs:subClassOf obo:HP_0000388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000372 obo:IAO_0000115 "An abnormality of the External acoustic tube (also known as the auditory canal)." ; oboInOwl:hasDbXref "UMLS:C4021807" ; oboInOwl:hasExactSynonym "Auditory canal abnormality" ; oboInOwl:id "HP:0000372" ; a owl:Class ; rdfs:label "Abnormality of the auditory canal" ; rdfs:subClassOf obo:HP_0000356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001352 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000375 obo:IAO_0000115 "An abnormality of the cochlea." ; oboInOwl:hasDbXref "UMLS:C4025858" ; oboInOwl:hasExactSynonym "Abnormality of cochlea" ; oboInOwl:id "HP:0000375" ; a owl:Class ; rdfs:comment "The cochlea is an inner ear structure comprised of a snail-shell like structure divided into three fluid-filled parts. Two are canals for the transmission of pressure and in the third is the organ of Corti, which detects pressure impulses and responds with electrical impulses which travel along the auditory nerve to the brain." ; rdfs:label "Abnormal cochlea morphology" ; rdfs:subClassOf obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000376 obo:IAO_0000115 "With incomplete partition II, the cochlea consists of 1.5 turns; the apical and middle cochlea turns are undifferentiated and form a cystic apex. The vestibule is normal while the vestibular aqueduct is always enlarged. Developmental arrest occurs at the seventh week of gestation." ; oboInOwl:hasDbXref "UMLS:C1857078", "UMLS:C4025857" ; oboInOwl:hasRelatedSynonym "Cochlear malformation defect (Mondini dysplasia)", "Mondini defect", "Mondini dysplasia", "Mondini malformation" ; oboInOwl:id "HP:0000376" ; a owl:Class ; rdfs:comment "The triad of incomplete partition of the cochlea type II, dilation of the vestibule, and an enlarged vestibular aqueduct was previously referred to as a Mondini malformation but this nomenclature is no longer recommended. It is important to note that while reading the related literature, it is often not easy to understand if the authors use the correct terminology, so even in recent studies, the term Mondini should be considered with caution." ; rdfs:label "Incomplete partition of the cochlea type II" ; rdfs:subClassOf obo:HP_0011373 . obo:HP_0000377 obo:IAO_0000115 "An abnormality of the pinna, which is also referred to as the auricle or external ear." ; oboInOwl:hasAlternativeId "HP:0000390", "HP:0000398", "HP:0004465", "HP:0008562", "HP:0008566", "HP:0008567", "HP:0008580", "HP:0008582", "HP:0008602", "HP:0040111" ; oboInOwl:hasDbXref "SNOMEDCT_US:253255002", "UMLS:C0431483", "UMLS:C0857379" ; oboInOwl:hasExactSynonym "Abnormal form of ears", "Abnormally shaped ears", "Auricular malformation", "Deformed auricles", "Deformed ears", "Dysplastic ears", "Malformation of auricle", "Malformed auricles", "Malformed ears", "Malformed external ears", "Minor malformation of the auricles", "Poorly defined conchae" ; oboInOwl:id "HP:0000377" ; a owl:Class ; rdfs:comment "The term 'dysplastic' is no longer accepted as a descriptor for an ear with unusual morphology. Each specific anatomical component of the ear should be described when the ear is thought to be abnormal in appearance." ; rdfs:label "Abnormal pinna morphology" ; rdfs:subClassOf obo:HP_0000356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000378 obo:IAO_0000115 "Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura)." ; oboInOwl:hasAlternativeId "HP:0008531", "HP:0008600" ; oboInOwl:hasDbXref "UMLS:C1845447", "UMLS:C4020892" ; oboInOwl:hasExactSynonym "Cup-shaped ears", "Cupped ear", "Simple, cup-shaped ears" ; oboInOwl:hasRelatedSynonym "Capuchin ears", "Cupped ears" ; oboInOwl:id "HP:0000378" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cupped ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0000381 obo:IAO_0000115 "Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles)." ; oboInOwl:hasDbXref "UMLS:C1861326" ; oboInOwl:hasExactSynonym "Stapes fixation" ; oboInOwl:id "HP:0000381" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Stapes ankylosis may be congenital or acquired, in which case it is referred to as otosclerosis. Otosclerosis is the most common cause of progressive conductive hearing loss in adults, and is generally manifested as nonsyndromic, delayed-onset, conductive hearing loss, but it may also affect the inner ear to cause sensorineural loss. Congenital stapes ankylosis may be difficult to differentiate from otosclerosis when the diagnosis of conductive hearing loss is delayed." ; rdfs:label "Stapes ankylosis" ; rdfs:subClassOf obo:HP_0008628 . obo:HP_0000383 oboInOwl:hasDbXref "UMLS:C4025856" ; oboInOwl:hasExactSynonym "Abnormality of periauricular region" ; oboInOwl:hasNarrowSynonym "Abnormality of the region around the ear", "Anomaly of the periauricular region", "Deformity of the periauricular region", "Malformation of the periauricular region" ; oboInOwl:id "HP:0000383" ; a owl:Class ; rdfs:label "Abnormal periauricular region morphology" ; rdfs:subClassOf obo:HP_0004426 . obo:HP_0000384 obo:IAO_0000115 "A rudimentary tag of skin often containing ear tissue including a core of cartilage and located just anterior to the auricle (outer part of the ear)." ; oboInOwl:hasAlternativeId "HP:0008575", "HP:0100278" ; oboInOwl:hasBroadSynonym "Skin tag in front of the ear", "Skin tag on the posterior cheek" ; oboInOwl:hasDbXref "UMLS:C1860816", "UMLS:C4072826" ; oboInOwl:hasExactSynonym "Ear tag", "Periauricular skin tag", "Preauricular acrochordon", "Preauricular fibroepithelial polyp", "Preauricular skin tags", "Preauricular tag", "Preauricular tags" ; oboInOwl:id "HP:0000384" ; a owl:Class ; rdfs:label "Preauricular skin tag" ; rdfs:subClassOf obo:HP_0000383, obo:HP_0010609 . obo:HP_0000385 obo:IAO_0000115 "Reduced volume of the earlobe." ; oboInOwl:hasAlternativeId "HP:0008616" ; oboInOwl:hasDbXref "UMLS:C1842680" ; oboInOwl:hasExactSynonym "Hypoplastic earlobes", "Hypoplastic lobules", "Small earlobe", "Small earlobes" ; oboInOwl:id "HP:0000385" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "All gradations in size of the earlobe may be seen from absent to clearly enlarged compared to average. This finding is highly variable." ; rdfs:label "Small earlobe" ; rdfs:subClassOf obo:HP_0009906 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001847 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000387 obo:IAO_0000115 "Absence of fleshy non-cartilaginous tissue inferior to the tragus and incisura." ; oboInOwl:hasDbXref "UMLS:C1849364" ; oboInOwl:hasExactSynonym "Absent ear lobes", "Absent earlobe", "Earlobe, absent", "Lobeless ears", "Lobule aplasia" ; oboInOwl:id "HP:0000387" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent earlobe" ; rdfs:subClassOf obo:HP_0009906 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001757 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001847 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000388 obo:IAO_0000115 "Inflammation or infection of the middle ear." ; oboInOwl:hasDbXref "MSH:D010033", "SNOMEDCT_US:65363002", "UMLS:C0029882" ; oboInOwl:hasExactSynonym "Middle ear infection" ; oboInOwl:id "HP:0000388" ; a owl:Class ; rdfs:label "Otitis media" ; rdfs:subClassOf obo:HP_0000370, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000389 obo:IAO_0000115 "Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear." ; oboInOwl:hasAlternativeId "HP:0008524" ; oboInOwl:hasDbXref "SNOMEDCT_US:21186006", "UMLS:C0271441", "UMLS:C0743359" ; oboInOwl:hasExactSynonym "Chronic infections of the middle ear", "Otitis media, chronic" ; oboInOwl:hasRelatedSynonym "Chronic ear infection", "Chronic middle ear infection" ; oboInOwl:id "HP:0000389" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Chronic otitis media" ; rdfs:subClassOf obo:HP_0000388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000391 obo:IAO_0000115 "Increased thickness of the helix of the ear." ; oboInOwl:hasDbXref "UMLS:C1837732" ; oboInOwl:hasExactSynonym "Thick helix" ; oboInOwl:id "HP:0000391" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thickened helices" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000394 obo:IAO_0000115 "Anterior and inferior folding of the upper portion of the ear that obliterates triangular fossa and scapha." ; oboInOwl:hasDbXref "SNOMEDCT_US:76223006", "UMLS:C0266614" ; oboInOwl:id "HP:0000394" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The term 'lop ear' refers to excessive protrusion of the ear from the side of the head, that is, the external ear stands away from the head at a greater than normal angle (Normal angle of the auricle to the median plane averages 25 degrees in boys and 18 degrees in girls). Lop ears are usually larger than normal ears. Mild forms are limited to the superior ear, more severe forms affect the superior and posterior ear. The concha may be excessively concave. This should be distinguished from an Overfolded helix where the external contour of the ear is normal." ; rdfs:label "Lop ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0000395 obo:IAO_0000115 "The presence of an abnormally prominent antihelix." ; oboInOwl:hasDbXref "UMLS:C1845272" ; oboInOwl:id "HP:0000395" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent antihelix" ; rdfs:subClassOf obo:HP_0009738 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000396 obo:IAO_0000115 "A condition in which the helix is folded over to a greater degree than normal. That is, excessive curling of the helix edge, whereby the free edge is parallel to the plane of the ear." ; oboInOwl:hasAlternativeId "HP:0001758", "HP:0008570" ; oboInOwl:hasDbXref "UMLS:C1837731" ; oboInOwl:hasExactSynonym "Over-folded helices", "Overfolded ears", "Overfolded helices" ; oboInOwl:id "HP:0000396" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is most often seen in the superior helix where it must be distinguished from a Lop ear (where the usual convexity of the posterior border of the ear is lost). Helix folding is highly variable." ; rdfs:label "Overfolded helix" ; rdfs:subClassOf obo:HP_0008544 . obo:HP_0000399 obo:IAO_0000115 "A form of sensorineural deafness with either congenital onset or infantile onset, i.e., before the acquisition of speech." ; oboInOwl:hasAlternativeId "HP:0001731" ; oboInOwl:hasDbXref "UMLS:C4021806" ; oboInOwl:hasExactSynonym "Deafness, sensorineural, prelingual", "Prelingual sensorineural deafness" ; oboInOwl:id "HP:0000399" ; a owl:Class ; rdfs:label "Prelingual sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0011474 . obo:HP_0000400 obo:IAO_0000115 "Median longitudinal ear length greater than two standard deviations above the mean and median ear width greater than two standard deviations above the mean (objective); or, apparent increase in length and width of the pinna (subjective)." ; oboInOwl:hasAlternativeId "HP:0000382", "HP:0000386", "HP:0000401", "HP:0001755" ; oboInOwl:hasDbXref "SNOMEDCT_US:275480001", "SNOMEDCT_US:69056000", "UMLS:C0152421", "UMLS:C0554972", "UMLS:C1835581", "UMLS:C1848570", "UMLS:C1850189", "UMLS:C1855062", "UMLS:C1860838" ; oboInOwl:hasExactSynonym "Large ears", "Large pinnae" ; oboInOwl:id "HP:0000400" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is acknowledged to be a bundled term but retained here because of its usefulness in practice. Ear length is determined by the maximal distance from the superior aspect to the inferior aspect of the external ear. If only length is increased the term Long ear should be used." ; rdfs:label "Macrotia" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000402 obo:IAO_0000115 "An abnormal narrowing of the external auditory canal." ; oboInOwl:hasAlternativeId "HP:0000373" ; oboInOwl:hasBroadSynonym "Narrow ear canal" ; oboInOwl:hasDbXref "SNOMEDCT_US:300127002", "SNOMEDCT_US:301061006", "UMLS:C0395837", "UMLS:C0576860" ; oboInOwl:hasExactSynonym "External auditory canal stenosis", "Narrow auditory canals", "Narrow external auditory canals", "Narrow external auditory meatus", "Narrowing of passageway from outer ear to middle ear", "Stenotic external auditory canal" ; oboInOwl:id "HP:0000402" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Stenosis of the external auditory canal" ; rdfs:subClassOf obo:HP_0000372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001352 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000403 obo:IAO_0000115 "Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media." ; oboInOwl:hasAlternativeId "HP:0008622", "HP:0008623", "HP:0008624" ; oboInOwl:hasDbXref "UMLS:C0747085" ; oboInOwl:hasExactSynonym "Frequent otitis media", "Multiple episodes of otitis media", "Otitis media, recurrent", "Recurrent episodes of otitis media", "Recurrent middle ear infection", "Susceptibility to otitis media" ; oboInOwl:id "HP:0000403" ; a owl:Class ; rdfs:label "Recurrent otitis media" ; rdfs:subClassOf obo:HP_0000388, obo:HP_0002719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001561 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000405 obo:IAO_0000115 "An abnormality of vibrational conductance of sound to the inner ear leading to impairment of sensory perception of sound." ; oboInOwl:hasAlternativeId "HP:0000367", "HP:0008581" ; oboInOwl:hasDbXref "MSH:D006314", "SNOMEDCT_US:44057004", "UMLS:C0018777" ; oboInOwl:hasExactSynonym "Conduction deafness", "Conductive deafness", "Conductive hearing loss", "Hearing loss, conductive" ; oboInOwl:id "HP:0000405" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A conductive hearing impariment with greater than 90 dB loss." ; rdfs:label "Conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000365, obo:HP_0011452 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055127 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000407 obo:IAO_0000115 "A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve." ; oboInOwl:hasAlternativeId "HP:0000374", "HP:0001753", "HP:0001916", "HP:0008538", "HP:0008553", "HP:0008565", "HP:0008576", "HP:0008611", "HP:0008613", "HP:0008614" ; oboInOwl:hasDbXref "MSH:D006319", "SNOMEDCT_US:60700002", "UMLS:C0018784" ; oboInOwl:hasExactSynonym "Hearing loss, sensorineural", "Sensorineural deafness", "Sensorineural hearing loss" ; oboInOwl:id "HP:0000407" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII, also known as the cochlear nerve)." ; rdfs:label "Sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000365, obo:HP_0011389 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0007605 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001021 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000408 obo:IAO_0000115 "A progressive form of sensorineural hearing impairment." ; oboInOwl:hasAlternativeId "HP:0000397", "HP:0000406", "HP:0008592", "HP:0008601", "HP:0008617" ; oboInOwl:hasDbXref "UMLS:C1843156" ; oboInOwl:hasExactSynonym "Bilateral progressive sensorineural hearing loss", "Hearing loss, progressive sensorineural", "Hearing loss, sensorineural, bilateral, progressive", "Hearing loss, sensorineural, progressive", "Progressive bilateral sensorineural hearing loss", "Sensorineural hearing loss, progressive" ; oboInOwl:id "HP:0000408" ; a owl:Class ; rdfs:label "Progressive sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407, obo:HP_0001730 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0000410 obo:IAO_0000115 "A type of hearing loss resulting from a combination of conductive hearing impairment and sensorineural hearing impairment." ; oboInOwl:hasDbXref "MSH:D046089", "SNOMEDCT_US:77507001", "UMLS:C0155552" ; oboInOwl:hasExactSynonym "Hearing loss, mixed", "Mixed hearing impairment", "Mixed hearing loss" ; oboInOwl:id "HP:0000410" ; a owl:Class ; rdfs:label "Mixed hearing impairment" ; rdfs:subClassOf obo:HP_0000405, obo:HP_0000407 . obo:HP_0000411 obo:IAO_0000115 "Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective)." ; oboInOwl:hasAlternativeId "HP:0000412" ; oboInOwl:hasDbXref "SNOMEDCT_US:275478007", "UMLS:C1305420", "UMLS:C1855285" ; oboInOwl:hasExactSynonym "Prominent ear", "Prominent ears" ; oboInOwl:hasRelatedSynonym "Protruding ears" ; oboInOwl:id "HP:0000411" ; a owl:Class ; rdfs:label "Protruding ear" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000413 obo:IAO_0000115 "Absence or failure to form of the external auditory canal." ; oboInOwl:hasAlternativeId "HP:0008547", "HP:0008564", "HP:0008626" ; oboInOwl:hasDbXref "UMLS:C1398325", "UMLS:C1840305", "UMLS:C1857079", "UMLS:C1866190" ; oboInOwl:hasExactSynonym "Absent auditory canals", "Absent ear canal", "Absent external auditory canals", "Atretic auditory canal", "Atretic auditory canals", "Atretic external auditory canal", "Atretic external auditory canals", "Auditory canal atresia", "External acoustic meatus atresia", "External auditory canal atresia", "External auditory meatal atresia", "External auditory meatus atresia" ; oboInOwl:hasRelatedSynonym "Atresia of the external auditory canals" ; oboInOwl:id "HP:0000413" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Atresia of the external auditory canal" ; rdfs:subClassOf obo:HP_0000372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001352 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000414 obo:IAO_0000115 "Increased volume and globular shape of the anteroinferior aspect of the nose." ; oboInOwl:hasAlternativeId "HP:0000443" ; oboInOwl:hasDbXref "MSH:C538354", "UMLS:C0240543", "UMLS:C1834118", "UMLS:C1855751" ; oboInOwl:hasExactSynonym "Bulbous nose" ; oboInOwl:hasRelatedSynonym "Bulbous nasal tip", "Potato nose" ; oboInOwl:id "HP:0000414" ; a owl:Class ; rdfs:comment "This is a bundled term, but as it is useful in practice it is kept here. This alteration of size and shape may be limited to the tip, but may involve the lower third of the nose. If only the width of the nasal tip is increased this should be coded as Broad nasal tip." ; rdfs:label "Bulbous nose" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000415 obo:IAO_0000115 "Abnormality of the choanae (the posterior nasal apertures)." ; oboInOwl:hasDbXref "UMLS:C4025855" ; oboInOwl:id "HP:0000415" ; a owl:Class ; rdfs:label "Abnormality of the choanae" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010425 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000417 oboInOwl:hasDbXref "UMLS:C1857645" ; oboInOwl:hasExactSynonym "Slender nose" ; oboInOwl:id "HP:0000417" ; a owl:Class ; rdfs:label "Slender nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000418 obo:IAO_0000115 "Decreased width of the nasal ridge." ; oboInOwl:hasDbXref "UMLS:C1837761" ; oboInOwl:hasExactSynonym "Decreased width of dorsum of nose", "Decreased width of nasal dorsum", "Decreased width of nasal ridge", "Narrow dorsum of nose", "Narrow nasal dorsum", "Narrow nasal ridge", "Pinched nose", "Thin dorsum of nose", "Thin nasal dorsum", "Thin nasal ridge" ; oboInOwl:id "HP:0000418" ; a owl:Class ; rdfs:comment "This feature may be accompanied by narrow nasal bridge and narrow nasal base, which should be coded separately." ; rdfs:label "Narrow nasal ridge" ; rdfs:subClassOf obo:HP_0011119 . obo:HP_0000419 obo:IAO_0000115 "An abnormality of the nasal septum." ; oboInOwl:hasDbXref "SNOMEDCT_US:95433000", "UMLS:C0151790" ; oboInOwl:hasExactSynonym "Abnormality of septum of nose", "Abnormality of the nasal septum", "Anomaly of nasal septum", "Anomaly of septum of nose" ; oboInOwl:id "HP:0000419" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal nasal septum morphology" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000420 obo:IAO_0000115 "Reduced superior to inferior length of the nasal septum." ; oboInOwl:hasDbXref "UMLS:C1844857" ; oboInOwl:hasExactSynonym "Decreased length of nasal septum", "Decreased length of septum of nose", "Short nasal septum", "Short septum of nose" ; oboInOwl:id "HP:0000420" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short nasal septum" ; rdfs:subClassOf obo:HP_0000419 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000421 obo:IAO_0000115 "Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose." ; oboInOwl:hasDbXref "COHD:318556", "EFO:0003895", "ICD10:R04.0", "ICD9:784.7", "MSH:D004844", "NCIT:C26766", "SNOMEDCT_US:12441001", "SNOMEDCT_US:249366005", "UMLS:C0014591" ; oboInOwl:hasExactSynonym "Bloody nose", "Frequent nosebleeds", "Nasal haemorrhage", "Nasal hemorrhage", "Nose bleed", "Nose bleeding", "Nosebleed" ; oboInOwl:id "HP:0000421" ; a owl:Class ; rdfs:label "Epistaxis" ; rdfs:subClassOf obo:HP_0000366, obo:HP_0001892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000422 obo:IAO_0000115 "Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi." ; oboInOwl:hasAlternativeId "HP:0000423" ; oboInOwl:hasDbXref "UMLS:C4021805" ; oboInOwl:hasExactSynonym "Abnormality of the bridge of the nose", "Abnormality of the nasal bridge", "Abnormality of the nasal root" ; oboInOwl:hasNarrowSynonym "Deformity of the bridge of the nose", "Deformity of the nasal bridge", "Malformation of the bridge of the nose", "Malformation of the nasal bridge" ; oboInOwl:id "HP:0000422" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The nasal root is the most depressed, superior part of the nose along the nasal ridge." ; rdfs:label "Abnormal nasal bridge morphology" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000426 obo:IAO_0000115 "Anterior positioning of the nasal root in comparison to the usual positioning for age." ; oboInOwl:hasAlternativeId "HP:0000432", "HP:0000442", "HP:0004498", "HP:0005287" ; oboInOwl:hasDbXref "UMLS:C1854113", "UMLS:C4230640" ; oboInOwl:hasExactSynonym "Elevated nasal bridge", "High nasal bridge", "Prominent bridge of nose", "Prominent nasal bridge", "Prominent nasal root", "Protruding bridge of nose", "Protruding nasal bridge" ; oboInOwl:hasRelatedSynonym "Convex bridge of nose", "Convex nasal bridge" ; oboInOwl:id "HP:0000426" ; a owl:Class ; rdfs:comment "A prominent nasal bridge can occur irrespective of the width of the nasal bridge, and the width should be assessed separately. The nasal bridge becomes more prominent with age. Although the nasal root may be anteriorly placed without increasing the space between the eyes, prominence of the nasal bridge may be accompanied by Telecanthus or ocular Hypertelorism. If such findings are present these should be coded separately. Deep-set eyes may lead to the impression of a prominent nasal bridge, but this finding should be coded separately." ; rdfs:label "Prominent nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000429 obo:IAO_0000115 "An abnormality of the Ala of nose." ; oboInOwl:hasDbXref "UMLS:C2227020", "UMLS:C4021804", "UMLS:C4280631", "UMLS:C4280632" ; oboInOwl:hasExactSynonym "Abnormality of the nasal ala", "Abnormality of the nasal alae" ; oboInOwl:hasNarrowSynonym "Abnormality of the nasal alar cartilage", "Deformity of the nasal ala", "Deformity of the nasal alar cartilage", "Malformation of the nasal ala", "Malformation of the nasal alar cartilage" ; oboInOwl:id "HP:0000429" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The nasal ala is the tissue comprising the lateral boundary of the nose, inferiorly, surrounding the naris." ; rdfs:label "Abnormal morphology of the nasal alae" ; rdfs:subClassOf obo:HP_0010938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000430 obo:IAO_0000115 "Thinned, deficient, or excessively arched ala nasi." ; oboInOwl:hasAlternativeId "HP:0004497", "HP:0004507", "HP:0005276", "HP:0005277", "HP:0005286" ; oboInOwl:hasDbXref "UMLS:C1834055" ; oboInOwl:hasExactSynonym "Ala nasi, underdeveloped", "Alar cartilage hypoplasia", "Decreased size of nasal alae", "Hypoplastic alae nasae", "Hypoplastic alae nasi", "Hypoplastic alar cartilage", "Hypoplastic alar nasae", "Hypoplastic nares", "Hypoplastic nasal alae", "Hypoplastic nasal wings", "Hypoplastic nostrils", "Nasal cartilage hypoplasia", "Small nasal alae", "Thin hypoplastic alae nasi", "Underdeveloped tissue around nostril" ; oboInOwl:id "HP:0000430" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The alae nasi are the lateral portions of the nose or the wings of the nostrils, which partly encircle the nostrils (nares). They are usually about the width of the columella, but vary greatly depending on the shape of the nostril. Note that individuals may be described as having a Cleft ala nasi, but have a severely underdeveloped ala nasi. In an underdeveloped ala the continuity of the tissue encircling the nostril is undisturbed while in a cleft it is disrupted. With severe hypoplasia of the nasal alae, the nasal tip may appear depressed." ; rdfs:label "Underdeveloped nasal alae" ; rdfs:subClassOf obo:HP_0000429, obo:HP_0009924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000431 obo:IAO_0000115 "Increased breadth of the nasal bridge (and with it, the nasal root)." ; oboInOwl:hasAlternativeId "HP:0000424", "HP:0004500", "HP:0004504", "HP:0004650", "HP:0200139" ; oboInOwl:hasDbXref "SNOMEDCT_US:249321001", "UMLS:C1839764", "UMLS:C1849367" ; oboInOwl:hasExactSynonym "Broad nasal bridge", "Broad nasal root", "Broadened nasal bridge", "Increased breadth of bridge of nose", "Increased breadth of nasal bridge", "Increased width of bridge of nose", "Increased width of nasal bridge", "Nasal bridge broad", "Nasal bridge, wide", "Wide bridge of nose", "Wide nasal bridge", "Widened nasal bridge" ; oboInOwl:hasRelatedSynonym "Broad flat nasal bridge" ; oboInOwl:id "HP:0000431" ; a owl:Class ; rdfs:comment "Care should be taken to distinguish between increased width of bone and Fullness of paranasal tissue. A wide nasal bridge should be distinguished from Telecanthus and Hypertelorism. A wide nasal bridge can be either prominent or depressed, which should be coded separately." ; rdfs:label "Wide nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000433 oboInOwl:hasDbXref "UMLS:C4025854" ; oboInOwl:hasExactSynonym "Abnormality of mucosa of nose", "Abnormality of mucous membrane of nose", "Abnormality of nasal mucous membrane", "Abnormality of the nasal mucosa" ; oboInOwl:id "HP:0000433" ; a owl:Class ; rdfs:label "Abnormal nasal mucosa morphology" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001826 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000434 obo:IAO_0000115 "Telangiectasia of the nasal mucosa." ; oboInOwl:hasDbXref "UMLS:C4025853" ; oboInOwl:hasExactSynonym "Angioectasia of mucosa of nose", "Angioectasia of mucous membrane of nose", "Angioectasia of nasal mucous membrane", "Nasal mucous membrane telangiectasia", "Spider veins of mucosa of nose", "Spider veins of mucous membrane of nose", "Spider veins of nasal mucous membrane", "Telangiectasia of mucosa of nose", "Telangiectasia of mucous membrane of nose", "Telangiectasia of nasal mucous membrane" ; oboInOwl:id "HP:0000434" ; a owl:Class ; rdfs:label "Nasal mucosa telangiectasia" ; rdfs:subClassOf obo:HP_0000433, obo:HP_0100579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000436 obo:IAO_0000115 "An abnormality of the nasal tip." ; oboInOwl:hasDbXref "UMLS:C4025852" ; oboInOwl:hasExactSynonym "Abnormality of the nasal tip", "Abnormality of tip of nose" ; oboInOwl:hasNarrowSynonym "Deformity of the nasal tip", "Deformity of tip of nose", "Malformation of the nasal tip", "Malformation of tip of nose" ; oboInOwl:id "HP:0000436" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The nasal tip is located at the junction of the inferior margin of the nasal ridge and the columella. Commonly, it is the part of the nose furthest from the plane of the face. In rare circumstances, such as markedly prominent and convex nasal profiles, other parts of the ridge may be further removed from the facial plane." ; rdfs:label "Abnormal nasal tip morphology" ; rdfs:subClassOf obo:HP_0010938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000437 obo:IAO_0000115 "Decreased distance from the nasal tip to the nasal base." ; oboInOwl:hasAlternativeId "HP:0005279" ; oboInOwl:hasDbXref "UMLS:C1859717" ; oboInOwl:hasExactSynonym "Caved in nasal tip", "Depressed nasal tip", "Depressed tip of nose", "Flat nasal tip", "Flat tip of nose", "Flattened nasal tip", "Nasal tip, depressed", "Nasal tip, recessed", "Nasal tip, retruded", "Retruded tip of nose" ; oboInOwl:id "HP:0000437" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This often accompanies a Short columella, Overhanging nasal tip, and Underdeveloped nasal tip, but these should be assessed and coded separately." ; rdfs:label "Depressed nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000444 obo:IAO_0000115 "Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low." ; oboInOwl:hasAlternativeId "HP:0003683" ; oboInOwl:hasDbXref "UMLS:C0240538" ; oboInOwl:hasExactSynonym "Beaked nose", "Beaklike protrusion", "Convex dorsum of nose", "Convex nasal dorsum", "Hooked nose", "Polly beak nasal deformity" ; oboInOwl:id "HP:0000444" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Convex nasal ridge" ; rdfs:subClassOf obo:HP_0011119 . obo:HP_0000445 obo:IAO_0000115 "Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae." ; oboInOwl:hasAlternativeId "HP:0000438" ; oboInOwl:hasDbXref "SNOMEDCT_US:249321001", "UMLS:C0426421" ; oboInOwl:hasExactSynonym "Broad nose", "Increased breadth of nose", "Increased nasal breadth", "Increased nasal width", "Increased width of nose", "Wide nose" ; oboInOwl:id "HP:0000445" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Wide nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000446 obo:IAO_0000115 "Decreased width of the bony bridge of the nose." ; oboInOwl:hasAlternativeId "HP:0100782" ; oboInOwl:hasDbXref "UMLS:C4551564" ; oboInOwl:hasExactSynonym "Narrow bridge of nose", "Narrow nasal bridge", "Narrow nasal root", "Nasal Bridge, Narrow", "Nasal bridge, thin" ; oboInOwl:hasRelatedSynonym "Pinched bridge of nose", "Pinched nasal bridge" ; oboInOwl:id "HP:0000446" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The narrowness may be accompanied by a sharp, keel-shaped appearance. The nasal bridge may narrow with age." ; rdfs:label "Narrow nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000447 oboInOwl:hasDbXref "UMLS:C1853482" ; oboInOwl:hasExactSynonym "Pear-shaped nose" ; oboInOwl:id "HP:0000447" ; a owl:Class ; rdfs:label "Pear-shaped nose" ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0000448 obo:IAO_0000115 "Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip." ; oboInOwl:hasAlternativeId "HP:0000461", "HP:0005271", "HP:0200140" ; oboInOwl:hasDbXref "SNOMEDCT_US:249311009", "UMLS:C0426415", "UMLS:C1400105", "UMLS:C4280629" ; oboInOwl:hasExactSynonym "Big nose", "Disproportionately large nose", "Increased nasal size", "Increased size of nose", "Large nose", "Prominent nose", "Pronounced nose" ; oboInOwl:hasRelatedSynonym "Hyperplasia of nose", "Hypertrophy of nose", "Nasal hyperplasia", "Nasal hypertrophy" ; oboInOwl:id "HP:0000448" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000451 oboInOwl:hasDbXref "UMLS:C1839765" ; oboInOwl:hasExactSynonym "Triangular nasal tip", "Triangular shaped tip of nose" ; oboInOwl:id "HP:0000451" ; a owl:Class ; rdfs:label "Triangular nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000452 obo:IAO_0000115 "Abnormal narrowing of the choana (the posterior nasal aperture)." ; oboInOwl:hasDbXref "SNOMEDCT_US:306963008", "UMLS:C0584837" ; oboInOwl:hasExactSynonym "Coanal stenosis", "Narrowing of the rear opening of the nasal cavity" ; oboInOwl:id "HP:0000452" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Choanal stenosis" ; rdfs:subClassOf obo:HP_0000415 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010425 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000453 obo:IAO_0000115 "Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral." ; oboInOwl:hasAlternativeId "HP:0000416", "HP:0004496", "HP:0004503" ; oboInOwl:hasDbXref "Fyler:4203", "MSH:D002754", "SNOMEDCT_US:204508009", "UMLS:C0008297" ; oboInOwl:hasExactSynonym "Blockage of the rear opening of the nasal cavity" ; oboInOwl:id "HP:0000453" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Choanal atresia" ; rdfs:subClassOf obo:HP_0000415 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000454 oboInOwl:hasDbXref "SNOMEDCT_US:21558008", "SNOMEDCT_US:248568003", "UMLS:C0277873" ; oboInOwl:hasExactSynonym "Flared nasal alae", "Flared nostrils" ; oboInOwl:id "HP:0000454" ; a owl:Class ; rdfs:label "Flared nostrils" ; rdfs:subClassOf obo:HP_0000429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000455 obo:IAO_0000115 "Increase in width of the nasal tip." ; oboInOwl:hasAlternativeId "HP:0004501", "HP:0005269" ; oboInOwl:hasDbXref "SNOMEDCT_US:249327002", "UMLS:C0426429" ; oboInOwl:hasExactSynonym "Broad nasal tip", "Broad tip of nose", "Broad, upturned nose", "Increased breadth of nasal tip", "Increased breadth of tip of nose", "Increased width of nasal tip", "Increased width of tip of nose", "Nasal tip, broad", "Nasal tip, wide", "Wide tip of nose" ; oboInOwl:hasRelatedSynonym "Broad upturned nose" ; oboInOwl:id "HP:0000455" ; a owl:Class ; rdfs:comment "Nasal tip width is assessed at the anterior junction of the alae and the tip. This is easier in persons with a somewhat squared shape of the nasal tip. This may be best viewed from the inferior aspect of the nose. No objective measures are available. See Bulbous nose for a related term." ; rdfs:label "Broad nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000456 obo:IAO_0000115 "A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip." ; oboInOwl:hasAlternativeId "HP:0005282" ; oboInOwl:hasDbXref "SNOMEDCT_US:249326006", "UMLS:C0426428", "UMLS:C4020890" ; oboInOwl:hasExactSynonym "Bifid tip of nose", "Cleft nasal tip" ; oboInOwl:hasRelatedSynonym "Cleft tip of nose", "Notched nasal tip", "Notched tip of nose" ; oboInOwl:id "HP:0000456" ; a owl:Class ; rdfs:comment "This is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation." ; rdfs:label "Bifid nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000457 obo:IAO_0000115 "Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge." ; oboInOwl:hasDbXref "UMLS:C1842876" ; oboInOwl:hasExactSynonym "Depressed dorsum of nose", "Depressed nasal dorsum", "Flat dorsum of nose", "Flat nasal dorsum", "Flat nose", "Recessed dorsum of nose", "Recessed nasal dorsum", "Recessed nasal ridge", "Retruded dorsum of nose", "Retruded nasal dorsum", "Retruded nasal ridge" ; oboInOwl:id "HP:0000457" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The adjective 'depressed' here does not indicate an active process but a status. The feature should be assessed in a profile view. This finding is typically associated with a Short columella, but this should be assessed separately." ; rdfs:label "Depressed nasal ridge" ; rdfs:subClassOf obo:HP_0011119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000458 obo:IAO_0000115 "An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell." ; oboInOwl:hasDbXref "MSH:D000857", "SNOMEDCT_US:44169009", "UMLS:C0003126" ; oboInOwl:hasExactSynonym "Loss of smell", "Lost smell" ; oboInOwl:id "HP:0000458" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anosmia" ; rdfs:subClassOf obo:HP_0004408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007608 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000460 obo:IAO_0000115 "Interalar distance more than 2 SD below the mean for age, or alternatively, an apparently decreased width of the nasal base and alae." ; oboInOwl:hasDbXref "SNOMEDCT_US:249322008", "UMLS:C0426422" ; oboInOwl:hasExactSynonym "Decreased nasal breadth", "Decreased nasal width", "Narrow nose", "Thin nose" ; oboInOwl:id "HP:0000460" ; a owl:Class ; rdfs:comment "Note: a small nose has both decreased height and a decreased width. These should be coded separately." ; rdfs:label "Narrow nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000463 obo:IAO_0000115 "Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip)." ; oboInOwl:hasAlternativeId "HP:0000427", "HP:0000435", "HP:0000441", "HP:0004495" ; oboInOwl:hasDbXref "SNOMEDCT_US:708670007", "UMLS:C1840077" ; oboInOwl:hasExactSynonym "Anteverted nose", "Anteverted nostrils", "Nasal tip, upturned", "Nostrils anteverted", "Upturned nares", "Upturned nasal tip", "Upturned nose", "Upturned nostrils" ; oboInOwl:hasRelatedSynonym "Upturned nasal tips" ; oboInOwl:id "HP:0000463" ; a owl:Class ; rdfs:comment "The tip of the nose is upturned and is positioned superiorly to the nasal base, allowing the nares to be easily visualized from the front. With maturation and growth of the nasal ridge and tip, the nares usually become more downwardly directed." ; rdfs:label "Anteverted nares" ; rdfs:subClassOf obo:HP_0000429, obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001474 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000464 obo:IAO_0000115 "An abnormality of the neck." ; oboInOwl:hasDbXref "SNOMEDCT_US:298390003", "SNOMEDCT_US:40052002", "UMLS:C0266623", "UMLS:C0575167", "UMLS:C4280628" ; oboInOwl:hasExactSynonym "Abnormality of the neck", "Anomaly of the neck" ; oboInOwl:hasNarrowSynonym "Deformity of the neck", "Malformation of the neck" ; oboInOwl:id "HP:0000464" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the neck" ; rdfs:subClassOf obo:HP_0000152 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000465 obo:IAO_0000115 "Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline." ; oboInOwl:hasDbXref "SNOMEDCT_US:11731003", "UMLS:C0221217" ; oboInOwl:hasExactSynonym "Neck webbing", "Pterygium colli", "Webbed neck" ; oboInOwl:id "HP:0000465" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Webbed neck" ; rdfs:subClassOf obo:HP_0025668 . obo:HP_0000466 oboInOwl:hasDbXref "UMLS:C1859212" ; oboInOwl:hasExactSynonym "Limited cervical range of motion", "Limited neck range of motion" ; oboInOwl:id "HP:0000466" ; a owl:Class ; rdfs:label "Limited neck range of motion" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0000467 obo:IAO_0000115 "Decreased strength of the neck musculature." ; oboInOwl:hasDbXref "UMLS:C0240479" ; oboInOwl:hasExactSynonym "Floppy neck", "Neck muscle weakness" ; oboInOwl:hasNarrowSynonym "Flaccid neck" ; oboInOwl:id "HP:0000467" ; a owl:Class ; rdfs:label "Neck muscle weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000468 obo:IAO_0000115 "An increased amount of subcutaneous fat tissue around the neck." ; oboInOwl:hasDbXref "UMLS:C4025850" ; oboInOwl:hasExactSynonym "Increased fat around the neck" ; oboInOwl:id "HP:0000468" ; a owl:Class ; rdfs:label "Increased adipose tissue around the neck" ; rdfs:subClassOf obo:HP_0009126, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000470 obo:IAO_0000115 "Diminished length of the neck." ; oboInOwl:hasAlternativeId "HP:0005992", "HP:0200137" ; oboInOwl:hasDbXref "SNOMEDCT_US:95427009", "UMLS:C0521525" ; oboInOwl:hasExactSynonym "Cervical shortening", "Decreased cervical height", "Decreased cervical length", "Decreased length of neck", "Short neck" ; oboInOwl:id "HP:0000470" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short neck" ; rdfs:subClassOf obo:HP_0003319, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000471 obo:IAO_0000115 "Dysplasia affecting the vasculature of the gastrointestinal tract." ; oboInOwl:hasDbXref "UMLS:C0854242" ; oboInOwl:hasExactSynonym "GI angiodysplasia" ; oboInOwl:id "HP:0000471" ; a owl:Class ; rdfs:label "Gastrointestinal angiodysplasia" ; rdfs:subClassOf obo:HP_0004296 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000472 obo:IAO_0000115 "Increased inferior-superior length of the neck." ; oboInOwl:hasDbXref "UMLS:C1839816" ; oboInOwl:hasExactSynonym "Cervical elongation", "Elongated neck", "Increased cervical length", "Increased length of neck", "Long neck" ; oboInOwl:id "HP:0000472" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long neck" ; rdfs:subClassOf obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000473 obo:IAO_0000115 "Involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head." ; oboInOwl:hasDbXref "MSH:D014103", "SNOMEDCT_US:270476009", "SNOMEDCT_US:70070008", "SNOMEDCT_US:74333002", "UMLS:C0040485", "UMLS:C0152116", "UMLS:C0949445" ; oboInOwl:hasExactSynonym "Cervical dystonia", "Loxia", "Spasmodic torticollis", "Wry neck" ; oboInOwl:id "HP:0000473" ; a owl:Class ; rdfs:comment "The word torticollis comes from Latin words meaning twisted neck. Spasmodic torticollis is a focal dystonia that affects the neck and sometimes the shoulders, leading to involuntary contractions of the neck muscles, abnormal movements and postures of the head and neck. The abnormal movements can have both tonic and clonic components and can results in pain and discomfort. Spasmodic torticollis is the most common focal dystonia." ; rdfs:label "Torticollis" ; rdfs:subClassOf obo:HP_0011006, obo:HP_0011442, obo:HP_0012179 . obo:HP_0000474 obo:IAO_0000115 "A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold (NF) measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. An NF measurement greater than 5 mm at 14 to 17+6 weeks of gestation, or 6 mm at 18 to 28 weeks has been associated with a markedly increased risk for Down syndrome." ; oboInOwl:hasAlternativeId "HP:0000477" ; oboInOwl:hasDbXref "UMLS:C1836940" ; oboInOwl:hasExactSynonym "Excess nuchal skin", "Increased nuchal fold", "Increased nuchal fold thickness", "Thick nuchal fold", "Thickened nuchal skin", "Thickened skin folds of neck", "Thickened skin over the neck" ; oboInOwl:id "HP:0000474" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The measurement of nuchal fold (NF) thickness during the second trimester is considered to be one of the most sensitive and specific isolated ultrasound marker for the identification of suspected cases of trisomy 21. Thick NF may also be seen in other aneuploidies as well as Turner's syndrome, Noonan's syndrome, Roberts syndrome, Zellweger syndrome and with congenital heart disease and with pathogenic CNVs. A thickened nuchal fold should be distinguished from cystic hygroma, in which the skin in this area has fluid-filled loculations. A thickened nuchal fold should not be confused with nuchal translucency, which is a specific measurement of fluid in the posterior aspect of the neck at 11 to 14 weeks gestation (see practice guidelines at http://www.sogc.org)." ; rdfs:label "Thickened nuchal skin fold" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0025667 . obo:HP_0000475 obo:IAO_0000115 "Increased side-to-side width of the neck." ; oboInOwl:hasDbXref "UMLS:C1853638" ; oboInOwl:hasExactSynonym "Broad neck", "Increased width of neck", "Wide neck" ; oboInOwl:hasRelatedSynonym "Thick neck" ; oboInOwl:id "HP:0000475" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad neck" ; rdfs:subClassOf obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000476 obo:IAO_0000115 "A cystic lymphatic lesion of the neck." ; oboInOwl:hasDbXref "MSH:D018191", "NCIT:C8965", "SNOMEDCT_US:399882002", "SNOMEDCT_US:40225001", "SNOMEDCT_US:423984004", "UMLS:C0206620" ; oboInOwl:hasExactSynonym "Cystic hygroma of the neck" ; oboInOwl:id "HP:0000476" ; a owl:Class ; rdfs:comment "Cystic hygroma refers to a cystic lymphatic lesion, that can in principle occur anywhere in the body, but is most commonly seen in the head and neck region. The term 'Cystic hygroma' alone is generally used to refer to cystic hygroma of the neck." ; rdfs:label "Cystic hygroma" ; rdfs:subClassOf obo:HP_0025668 . obo:HP_0000478 obo:IAO_0000115 "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." ; oboInOwl:hasDbXref "MSH:D005124", "MSH:D005128", "SNOMEDCT_US:19416009", "SNOMEDCT_US:371405004", "SNOMEDCT_US:371409005", "UMLS:C0015393", "UMLS:C0015397" ; oboInOwl:hasExactSynonym "Abnormal eye", "Abnormality of the eye" ; oboInOwl:hasRelatedSynonym "Eye disease" ; oboInOwl:id "HP:0000478" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the eye" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000479 obo:IAO_0000115 "A structural abnormality of the retina." ; oboInOwl:hasAlternativeId "HP:0007938" ; oboInOwl:hasDbXref "MSH:D012164", "SNOMEDCT_US:29555009", "UMLS:C0035300", "UMLS:C0035309" ; oboInOwl:hasExactSynonym "Abnormal retina", "Abnormality of the retina", "Anomaly of the retina", "Retina issue" ; oboInOwl:hasRelatedSynonym "Retinal disease" ; oboInOwl:id "HP:0000479" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal retinal morphology" ; rdfs:subClassOf obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000480 obo:IAO_0000115 "A notch or cleft of the retina." ; oboInOwl:hasAlternativeId "HP:0007808" ; oboInOwl:hasDbXref "UMLS:C3540764" ; oboInOwl:hasExactSynonym "Hole in the back of the eye" ; oboInOwl:id "HP:0000480" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal coloboma" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0000589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000481 obo:IAO_0000115 "Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber." ; oboInOwl:hasAlternativeId "HP:0007771", "HP:0007972" ; oboInOwl:hasDbXref "UMLS:C1855670", "UMLS:C4020889" ; oboInOwl:hasExactSynonym "Abnormality of the cornea", "Corneal abnormalities", "Corneal abnormality" ; oboInOwl:hasRelatedSynonym "Cornela disease" ; oboInOwl:id "HP:0000481" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal cornea morphology" ; rdfs:subClassOf obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000482 obo:IAO_0000115 "A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood." ; oboInOwl:hasAlternativeId "HP:0100688" ; oboInOwl:hasDbXref "SNOMEDCT_US:26098002", "UMLS:C0266544", "UMLS:C1167713" ; oboInOwl:hasExactSynonym "Cornea of eye less than 10mm in diameter", "Decreased corneal diameter" ; oboInOwl:id "HP:0000482" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that the cornea's diameter is normally about 9.5-10.0 mm at birth and reaches 10.0-12-5 mm in adulthood." ; rdfs:label "Microcornea" ; rdfs:subClassOf obo:HP_0001120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000483 obo:IAO_0000115 "A type of astigmatism associated with abnormal curvatures on the anterior and/or posterior surface of the cornea." ; oboInOwl:hasDbXref "MSH:D001251", "SNOMEDCT_US:82649003", "UMLS:C0004106" ; oboInOwl:hasExactSynonym "Abnormal curving of the cornea or lens of the eye", "Astigmatism" ; oboInOwl:id "HP:0000483" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The irregular curvature associated with astigmatism means that the optical system is not symmetric about the optical axis. Most commonly the cornea is affected such that the refractive power in one meridian is less than that of the perpendicular axis. Astigmatism of significant degree causes blurry vision." ; rdfs:label "Astigmatism" ; rdfs:subClassOf obo:HP_0000539, obo:HP_0100691 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001848 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000484 obo:IAO_0000115 "A form of astigmatism in which one meridian is hyperopic while the one at a right angle to it has no refractive error." ; oboInOwl:hasDbXref "SNOMEDCT_US:449734001", "UMLS:C1847524" ; oboInOwl:id "HP:0000484" ; a owl:Class ; rdfs:label "Hyperopic astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0000485 obo:IAO_0000115 "An enlargement of the cornea with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age." ; oboInOwl:hasAlternativeId "HP:0007660" ; oboInOwl:hasDbXref "MSH:C562829", "SNOMEDCT_US:204118005", "SNOMEDCT_US:268158009", "UMLS:C0344530", "UMLS:C1167712" ; oboInOwl:hasExactSynonym "Anterior megalophthalmos", "Enlarged cornea", "Increased corneal diameter", "Macrocornea" ; oboInOwl:id "HP:0000485" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Megalocornea" ; rdfs:subClassOf obo:HP_0001120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000486 obo:IAO_0000115 "A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error." ; oboInOwl:hasAlternativeId "HP:0000487" ; oboInOwl:hasDbXref "MSH:D013285", "SNOMEDCT_US:128602000", "SNOMEDCT_US:22066006", "UMLS:C0038379" ; oboInOwl:hasExactSynonym "Cross-eyed", "Squint", "Squint eyes" ; oboInOwl:id "HP:0000486" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Strabismus" ; rdfs:subClassOf obo:HP_0000549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001654 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010222 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000487 obo:IAO_0100001 "HP:0000486" ; oboInOwl:id "HP:0000487" ; a owl:Class ; rdfs:label "obsolete Congenital strabismus" ; owl:deprecated true . obo:HP_0000488 obo:IAO_0000115 "Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality." ; oboInOwl:hasDbXref "MSH:D012164", "SNOMEDCT_US:29555009", "UMLS:C0035309" ; oboInOwl:hasExactSynonym "Noninflammatory retina disease" ; oboInOwl:id "HP:0000488" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinopathy" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000489 oboInOwl:consider "HP:0100886", "HP:0100887" ; oboInOwl:id "HP:0000489" ; a owl:Class ; rdfs:label "obsolete Abnormality of globe location or size" ; owl:deprecated true . obo:HP_0000490 obo:IAO_0000115 "An eye that is more deeply recessed into the plane of the face than is typical." ; oboInOwl:hasAlternativeId "HP:0000663" ; oboInOwl:hasDbXref "MSH:D015841", "SNOMEDCT_US:246923005", "SNOMEDCT_US:80093006", "UMLS:C0014306", "UMLS:C0423224" ; oboInOwl:hasExactSynonym "Deep set eye", "Deep-set eyes", "Deeply set eye", "Enophthalmos", "Ocular depression", "Sunken eye", "Sunken eyes" ; oboInOwl:id "HP:0000490" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding should be distinguished from a prominent supraorbital ridge or inferior orbital margin. In Deeply set eyes, the globe is recessed in comparison to the overall prominence of the face. There is no known objective measurement, and diagnosing this feature depends heavily on the experience of the observer." ; rdfs:label "Deeply set eye" ; rdfs:subClassOf obo:HP_0100886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001477 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000491 obo:IAO_0000115 "Inflammation of the cornea." ; oboInOwl:hasDbXref "MSH:D007634", "SNOMEDCT_US:5888003", "UMLS:C0022568" ; oboInOwl:hasExactSynonym "Corneal inflammation" ; oboInOwl:id "HP:0000491" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Keratitis" ; rdfs:subClassOf obo:HP_0011495, obo:HP_0100533 . obo:HP_0000492 obo:IAO_0000115 "An abnormality of the eyelids." ; oboInOwl:hasAlternativeId "HP:0000285" ; oboInOwl:hasDbXref "UMLS:C4021803" ; oboInOwl:hasExactSynonym "Abnormality of the eyelid", "Abnormality of the eyelids" ; oboInOwl:id "HP:0000492" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal eyelid morphology" ; rdfs:subClassOf obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000493 obo:IAO_0000115 "An abnormality of the fovea centralis, the central area of the macula that mediates central, high resolution vision and contains the largest concentration of cone cells in the retina." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T01:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4025849" ; oboInOwl:hasExactSynonym "Abnormality of the fovea" ; oboInOwl:id "HP:0000493" ; a owl:Class ; rdfs:label "Abnormal foveal morphology" ; rdfs:subClassOf obo:HP_0001103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000494 obo:IAO_0000115 "The palpebral fissure inclination is more than two standard deviations below the mean." ; oboInOwl:hasAlternativeId "HP:0007714", "HP:0007908" ; oboInOwl:hasDbXref "SNOMEDCT_US:246800008", "UMLS:C0423110" ; oboInOwl:hasExactSynonym "Antimongoloid eye slant", "Antimongoloid slant of palpebral fissures", "Antimongoloid slanted palpebral fissures", "Down slanting palpebral fissures", "Down-slanted palpebral fissures", "Down-slanting palpebral fissure", "Down-slanting palpebral fissures", "Downslanting palpebral fissure", "Downslanting palpebral fissures", "Downward slanted palpebral fissures", "Downward slanting of the opening between the eyelids", "Downward slanting palpebral fissures", "Downward-slanting palpebral fissures", "Palpebral fissures down-slanted" ; oboInOwl:id "HP:0000494" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Downslanted palpebral fissures" ; rdfs:subClassOf obo:HP_0200006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002143 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000495 obo:IAO_0000115 "The presence of recurrent corneal epithelial erosions. Although most corneal epithelial defects heal quickly, some may show recurrent ulcerations." ; oboInOwl:hasAlternativeId "HP:0007674", "HP:0007749" ; oboInOwl:hasDbXref "MSH:D003320", "SNOMEDCT_US:2055003", "SNOMEDCT_US:91514001", "UMLS:C0010043", "UMLS:C0155119", "UMLS:C4020888" ; oboInOwl:hasExactSynonym "Corneal erosions, recurrent", "Recurrent breakdown of clear protective layer of eye", "Recurrent corneal ulceration" ; oboInOwl:hasRelatedSynonym "Epithelial corneal erosions", "Recurrent corneal ulcerations" ; oboInOwl:id "HP:0000495" ; a owl:Class ; rdfs:label "Recurrent corneal erosions" ; rdfs:subClassOf obo:HP_0200020 . obo:HP_0000496 obo:IAO_0000115 "An abnormality in voluntary or involuntary eye movements or their control." ; oboInOwl:hasAlternativeId "HP:0006860" ; oboInOwl:hasDbXref "SNOMEDCT_US:103252009", "UMLS:C0497202" ; oboInOwl:hasExactSynonym "Abnormal extraocular movement", "Abnormal extraocular movements", "Abnormal eye motility", "Abnormal eye movement", "Abnormal eye movements", "Abnormal motility of the globe of the eye", "Abnormal movement of the globe of the eye", "Abnormal ocular movements", "Abnormality of eye movement", "Eye movement abnormalities", "Eye movement issue", "Ocular movement abnormalities", "Oculomotor abnormalities" ; oboInOwl:id "HP:0000496" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of eye movement" ; rdfs:subClassOf obo:HP_0012373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000444 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000497 oboInOwl:hasDbXref "UMLS:C4025848" ; oboInOwl:id "HP:0000497" ; a owl:Class ; rdfs:label "Globe retraction and deviation on abduction" ; rdfs:subClassOf obo:HP_0011347 . obo:HP_0000498 obo:IAO_0000115 "Inflammation of the eyelids." ; oboInOwl:hasDbXref "MSH:D001762", "SNOMEDCT_US:231796003", "SNOMEDCT_US:41446000", "UMLS:C0005741", "UMLS:C0339063" ; oboInOwl:hasExactSynonym "Cellulitis of eyelids", "Inflammation of eyelids" ; oboInOwl:id "HP:0000498" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Blepharitis" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0100533 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000499 obo:IAO_0000115 "An abnormality of the eyelashes." ; oboInOwl:hasAlternativeId "HP:0004530" ; oboInOwl:hasDbXref "UMLS:C2675111" ; oboInOwl:hasExactSynonym "Abnormal eyelashes", "Abnormality of the eyelashes", "Eyelash abnormality" ; oboInOwl:id "HP:0000499" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal eyelash morphology" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000501 obo:IAO_0000115 "Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure." ; oboInOwl:hasDbXref "MSH:D005901", "SNOMEDCT_US:23986001", "UMLS:C0017601" ; oboInOwl:id "HP:0000501" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The feature that differentiates glaucoma from other causes of visual morbidity is a characteristic pattern of damage to the optic nerve head. This is most easily recognised at the superior and inferior poles of the optic disc. The vertical cup:disc ratio (VCDR) has proved to be a simple, relatively robust index of glaucomatous loss of the neuroretinal rim. As with intraocular pressure, VCDR is a continuous variable within the population." ; rdfs:label "Glaucoma" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0000502 obo:IAO_0000115 "An abnormality of the conjunctiva." ; oboInOwl:hasDbXref "UMLS:C4025847" ; oboInOwl:id "HP:0000502" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The conjunctiva is a thin, sparsely vascularized transparent membrane that covers and protects the sclera (the bulbar conjunctiva), and forms the inner lining of the eyelids (the tarsal conjunctiva)." ; rdfs:label "Abnormal conjunctiva morphology" ; rdfs:subClassOf obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001811 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000503 obo:IAO_0000115 "The presence of an increased number of twists and turns of the conjunctival blood vessels." ; oboInOwl:hasDbXref "UMLS:C1855391" ; oboInOwl:id "HP:0000503" ; a owl:Class ; rdfs:label "Tortuosity of conjunctival vessels" ; rdfs:subClassOf obo:HP_0008054 . obo:HP_0000504 obo:IAO_0000115 "Abnormality of eyesight (visual perception)." ; oboInOwl:hasDbXref "UMLS:C4025846" ; oboInOwl:hasExactSynonym "Abnormality of sight", "Abnormality of vision", "Vision issue" ; oboInOwl:id "HP:0000504" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of vision" ; rdfs:subClassOf obo:HP_0012373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000505 obo:IAO_0000115 "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." ; oboInOwl:hasAlternativeId "HP:0000516", "HP:0000566", "HP:0007758", "HP:0007860", "HP:0007983" ; oboInOwl:hasDbXref "MSH:D014786", "MSH:D015354", "SNOMEDCT_US:246635007", "SNOMEDCT_US:397540003", "SNOMEDCT_US:7973008", "UMLS:C0042798", "UMLS:C3665347" ; oboInOwl:hasExactSynonym "Impaired vision", "Loss of eyesight", "Poor vision", "Visual impairment" ; oboInOwl:id "HP:0000505" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Visual impairment" ; rdfs:subClassOf obo:HP_0000504 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000506 obo:IAO_0000115 "Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi." ; oboInOwl:hasDbXref "MSH:C562941", "SNOMEDCT_US:246803005", "UMLS:C0423113" ; oboInOwl:hasExactSynonym "Corners of eye widely separated", "Dystopia canthorum", "Increased distance between medial canthi", "Increased intercanthal distance" ; oboInOwl:id "HP:0000506" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Dystopia canthorum (also called telecanthus) describes a subtle but unusual facial feature in which the inner corners of the eyes (canthi) are spaced farther apart than normal, yet the eyes (pupils) themselves are not necessarily widely spaced." ; rdfs:label "Telecanthus" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013678 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000508 obo:IAO_0000115 "The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective)." ; oboInOwl:hasDbXref "MSH:D001763", "SNOMEDCT_US:11934000", "UMLS:C0005745" ; oboInOwl:hasExactSynonym "Blepharoptosis", "Drooping upper eyelid", "Eyelid ptosis" ; oboInOwl:hasRelatedSynonym "Eye drop" ; oboInOwl:id "HP:0000508" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ptosis" ; rdfs:subClassOf obo:HP_0012373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002165 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000509 obo:IAO_0000115 "Inflammation of the conjunctiva." ; oboInOwl:hasDbXref "MSH:D003231", "SNOMEDCT_US:9826008", "UMLS:C0009763", "UMLS:C1864156" ; oboInOwl:hasExactSynonym "Pink eye" ; oboInOwl:hasRelatedSynonym "Conjunctivitis, recurrent" ; oboInOwl:id "HP:0000509" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Conjunctivitis" ; rdfs:subClassOf obo:HP_0000502, obo:HP_0025337, obo:HP_0100533 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000510 obo:IAO_0000115 "An inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones." ; oboInOwl:hasAlternativeId "HP:0000547", "HP:0001127", "HP:0007635", "HP:0007645", "HP:0007742", "HP:0007816", "HP:0007826", "HP:0007927", "HP:0008036" ; oboInOwl:hasDbXref "MSH:D012174", "SNOMEDCT_US:28835009", "UMLS:C0035334" ; oboInOwl:hasExactSynonym "Retinitis pigmentosa", "Rod cone dystrophy" ; oboInOwl:id "HP:0000510" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Retinitis pigmentosa is a group of hereditary diseases of the eye. However, the term retinitis pigmentosa has also been used to describe the retinal findings characteristic of these diseases but also seen on other diseases such as Usher syndrome. It is preferable to describe the findings precisely if possible, but this term is kept for convenience." ; rdfs:label "Rod-cone dystrophy" ; rdfs:subClassOf obo:HP_0000556 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000546 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000511 obo:IAO_0000115 "A supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:246773002", "UMLS:C0339652", "UMLS:C1843369" ; oboInOwl:hasExactSynonym "Vertical gaze palsy" ; oboInOwl:id "HP:0000511" ; a owl:Class ; rdfs:comment "Vertical gaze palsies can manifest as selective limitation of upgaze or downgaze." ; rdfs:label "Vertical supranuclear gaze palsy" ; rdfs:subClassOf obo:HP_0000605 . obo:HP_0000512 obo:IAO_0000115 "Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography." ; oboInOwl:hasAlternativeId "HP:0003285" ; oboInOwl:hasDbXref "SNOMEDCT_US:274524001", "UMLS:C0476397" ; oboInOwl:hasExactSynonym "Abnormal ERG", "Abnormal electroretinography", "ERG abnormal" ; oboInOwl:id "HP:0000512" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The electrical responses of the photoreceptors (rods and cones), inner retinal cells (bipolar and amacrine cells), and the ganglion cells can be assessed by ERG." ; rdfs:label "Abnormal electroretinogram" ; rdfs:subClassOf obo:HP_0030453 . obo:HP_0000514 obo:IAO_0000115 "An abnormally slow velocity of the saccadic eye movements." ; oboInOwl:hasDbXref "SNOMEDCT_US:404686001", "UMLS:C1321329" ; oboInOwl:hasExactSynonym "Slow eye movements", "Slow saccades", "Slow visual tracking" ; oboInOwl:id "HP:0000514" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Saccades are rapid eye movements that align the fovea with the target." ; rdfs:label "Slow saccadic eye movements" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0000517 obo:IAO_0000115 "An abnormality of the lens." ; oboInOwl:hasDbXref "MSH:D007905", "SNOMEDCT_US:10810001", "UMLS:C0023308", "UMLS:C0549651" ; oboInOwl:hasExactSynonym "Abnormality of the lens", "Lens issue" ; oboInOwl:hasRelatedSynonym "Lens disease" ; oboInOwl:id "HP:0000517" ; a owl:Class ; rdfs:label "Abnormal lens morphology" ; rdfs:subClassOf obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000518 obo:IAO_0000115 "A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule." ; oboInOwl:hasAlternativeId "HP:0001113", "HP:0007825", "HP:0010700" ; oboInOwl:hasDbXref "Fyler:4865", "MSH:D002386", "SNOMEDCT_US:128306009", "SNOMEDCT_US:193570009", "SNOMEDCT_US:247053007", "UMLS:C0086543", "UMLS:C1510497" ; oboInOwl:hasExactSynonym "Cataracts", "Clouding of the lens of the eye", "Cloudy lens", "Lens opacities", "Lens opacity" ; oboInOwl:id "HP:0000518" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that some ophthalmologists call any opacity in the lens a cataract, while others restrict the term to lens opacities that impair vision. We use the term to refer to the first meaning (any lens opacity)." ; rdfs:label "Cataract" ; rdfs:subClassOf obo:HP_0000517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000963 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000519 obo:IAO_0000115 "A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens." ; oboInOwl:hasAlternativeId "HP:0001108", "HP:0007679", "HP:0007692", "HP:0007726", "HP:0007788" ; oboInOwl:hasDbXref "SNOMEDCT_US:609587005", "SNOMEDCT_US:79410001", "UMLS:C0009691", "UMLS:C3277059" ; oboInOwl:hasExactSynonym "Bilateral congenital cataracts", "Cataract, congenital", "Clouding of the lens of the eye at birth", "Congenital cataract", "Congenital cataracts", "Congenital cataracts, bilateral" ; oboInOwl:id "HP:0000519" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In general, congenital cataracts are bilateral and that is the assumption with the terms in this cataract subhierarchy." ; rdfs:label "Developmental cataract" ; rdfs:subClassOf obo:HP_0000518, obo:HP_0007700 . obo:HP_0000520 obo:IAO_0000115 "An eye that is protruding anterior to the plane of the face to a greater extent than is typical." ; oboInOwl:hasAlternativeId "HP:0000536", "HP:0000644", "HP:0000645", "HP:0007711", "HP:0007870" ; oboInOwl:hasDbXref "MSH:D005094", "SNOMEDCT_US:18265008", "UMLS:C0015300", "UMLS:C1837760", "UMLS:C1848490", "UMLS:C1862425" ; oboInOwl:hasExactSynonym "Anterior bulging of the globe", "Anterior bulging of the globe of eye", "Bulging eye", "Exophthalmos", "Eyeballs bulging out", "Ocular proptosis", "Prominent eyes", "Prominent globes", "Protruding eyes", "Protrusio bulbi" ; oboInOwl:id "HP:0000520" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Some sources define \"exophthalmos\" as a protrusion of the globe greater than 18 mm and \"proptosis\" as a protusion equal to or less than 18 mm. Others define \"exophthalmos\" as protusion secondary to endocrine dysfunction and \"proptosis\" as any non-endocrine-mediated protusion (Source: Wikipedia). This finding should be distinguished frm underdevelopment of the supraorbital ridge or maxilla/zygoma. In proptosis, the globe is anteriorly protuberant to the overall plane of the face." ; rdfs:label "Proptosis" ; rdfs:subClassOf obo:HP_0100886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000522 obo:IAO_0000115 "Absence of tear secretion." ; oboInOwl:hasDbXref "MSH:C562827", "SNOMEDCT_US:253215004", "UMLS:C0344505" ; oboInOwl:hasExactSynonym "Absence of tears in the eyes", "Absent lacrimal fluids", "Absent tear secretion" ; oboInOwl:id "HP:0000522" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Alacrima is generally a congenital deficiency." ; rdfs:label "Alacrima" ; rdfs:subClassOf obo:HP_0000633 . obo:HP_0000523 obo:IAO_0000115 "A cataract that affects the region of the lens directly beneath the capsule of the lens." ; oboInOwl:hasAlternativeId "HP:0001490", "HP:0007978" ; oboInOwl:hasDbXref "SNOMEDCT_US:95723009", "UMLS:C0235259" ; oboInOwl:hasExactSynonym "Subcapsular cataracts", "Subcapsular lenticular cataracts", "Subcapsular opacities" ; oboInOwl:id "HP:0000523" ; a owl:Class ; rdfs:label "Subcapsular cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0000524 obo:IAO_0000115 "The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva." ; oboInOwl:hasDbXref "SNOMEDCT_US:231870008", "UMLS:C0239105" ; oboInOwl:hasExactSynonym "Conjunctival telangiectases", "Small dilated blood vessels near membrane covering front of eye and eyelids", "Telangiectasia, conjunctival" ; oboInOwl:id "HP:0000524" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Conjunctival telangiectasia" ; rdfs:subClassOf obo:HP_0008054, obo:HP_0100579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000525 obo:IAO_0000115 "An abnormality of the iris, which is the pigmented muscular tissue between the cornea and the lens, that is perforated by an opening called the pupil." ; oboInOwl:hasDbXref "UMLS:C4025845" ; oboInOwl:hasExactSynonym "Abnormality of the iris" ; oboInOwl:id "HP:0000525" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality iris morphology" ; rdfs:subClassOf obo:HP_0000553, obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000526 obo:IAO_0000115 "Abnormality of the iris characterized by, typically bilateral, complete or partial iris hypoplasia. The phenotype ranges from mild defects of anterior iris stroma only to almost complete absence of the iris." ; oboInOwl:hasAlternativeId "HP:0011498" ; oboInOwl:hasDbXref "MSH:D015783", "SNOMEDCT_US:69278003", "UMLS:C0003076" ; oboInOwl:hasExactSynonym "Absent iris" ; oboInOwl:id "HP:0000526" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aniridia" ; rdfs:subClassOf obo:HP_0008053 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000527 obo:IAO_0000115 "Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective)." ; oboInOwl:hasAlternativeId "HP:0000500" ; oboInOwl:hasDbXref "UMLS:C1853738" ; oboInOwl:hasExactSynonym "Ciliary trichomegaly", "Eyelash trichomegaly", "Increased length of eyelashes", "Long eyelashes", "Unusually long eyelashes" ; oboInOwl:id "HP:0000527" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Measurement should be done on the longest lashes, which are usually at the center of the lid. Normal values are 7.99 - 1.05 mm in boys and 7.76 - 1.03 mm in girls. Note that Eyelash trichomegaly is defined as increase in length (12 mm or more), curling, pigmentation or thickness of eyelashes." ; rdfs:label "Long eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000528 obo:IAO_0000115 "Absence of the globe or eyeball." ; oboInOwl:hasAlternativeId "HP:0001485", "HP:0007664" ; oboInOwl:hasDbXref "Fyler:4864", "MSH:D000853", "SNOMEDCT_US:204099004", "SNOMEDCT_US:7183006", "UMLS:C0003119" ; oboInOwl:hasExactSynonym "Absence of eyeballs", "Absence of globes of eyes", "Anophthalmia, clinical", "Clinical anophthalmia, unilateral/bilateral", "Failure of development of eyeball", "Missing eyeball", "Missing globe of eye", "No eyeball", "No globe of eye", "Ocular absence" ; oboInOwl:id "HP:0000528" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anophthalmia" ; rdfs:subClassOf obo:HP_0008056, obo:HP_0100887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000529 obo:IAO_0000115 "A reduction of previously attained ability to see." ; oboInOwl:hasAlternativeId "HP:0000560", "HP:0007735", "HP:0007753", "HP:0007967" ; oboInOwl:hasDbXref "UMLS:C1839364", "UMLS:C3277697" ; oboInOwl:hasExactSynonym "Loss of visual acuity", "Progressive loss of vision", "Progressive vision loss", "Progressive visual acuity loss", "Progressive visual impairment", "Slowly progressive visual loss", "Vision loss, progressive", "Visual loss, progressive" ; oboInOwl:hasRelatedSynonym "Decreased visual acuity, progressive" ; oboInOwl:id "HP:0000529" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Progressive visual loss" ; rdfs:subClassOf obo:HP_0000572 . obo:HP_0000531 oboInOwl:hasDbXref "UMLS:C1096610" ; oboInOwl:hasExactSynonym "Corneal deposits" ; oboInOwl:id "HP:0000531" ; a owl:Class ; rdfs:label "Corneal crystals" ; rdfs:subClassOf obo:HP_0007759 . obo:HP_0000532 obo:IAO_0000115 "An abnormality of the choroid and retina." ; oboInOwl:hasAlternativeId "HP:0001145", "HP:0007888" ; oboInOwl:hasDbXref "UMLS:C4025844" ; oboInOwl:hasExactSynonym "Chorioretinal abnormality" ; oboInOwl:id "HP:0000532" ; a owl:Class ; rdfs:comment "The choroid is the vascular layer of the eye, located between the retina and the sclera." ; rdfs:label "Abnormal chorioretinal morphology" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0000610 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0000533 obo:IAO_0000115 "Atrophy of the choroid and retinal layers of the fundus." ; oboInOwl:hasAlternativeId "HP:0001150", "HP:0007884", "HP:0007918", "HP:0007931" ; oboInOwl:hasDbXref "SNOMEDCT_US:95686007", "UMLS:C4048273" ; oboInOwl:hasExactSynonym "Chorioretinal thinning" ; oboInOwl:id "HP:0000533" ; a owl:Class ; rdfs:comment "Choroidal sclerosis is a descriptive term applied to the ophthalmoscopic appearance of prominent white choroidal vessels in which the blood columns are not seen or are sheathed by white lines. Choroidal sclerosis is a term used to describe a group of genetically heterogeneous retinal dystrophies that share a common funduscopic phenotype of scalloped, well-circumscribed, and confluent chorioretinal atrophic lesions that extend beyond the macula. The term choroidal sclerosis was initially coined because of the sclerotic appearance of choroidal vessels which frequently appear white or light-yellow. However, histologic studies have demonstrated the term to be a misnomer as the principle abnormality is the loss of choriocapillaris, retinal pigment epithelium (RPE), and the outer retina in the absence of abnormal sclerotic changes in the choroidal vasculature. Therefore, we are making choroidal sclerosis a synonym of chorioretinal atrophy." ; rdfs:label "Chorioretinal atrophy" ; rdfs:subClassOf obo:HP_0200065 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0000534 obo:IAO_0000115 "An abnormality of the eyebrow." ; oboInOwl:hasDbXref "UMLS:C4011556" ; oboInOwl:hasExactSynonym "Abnormality of the eyebrow" ; oboInOwl:id "HP:0000534" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal eyebrow morphology" ; rdfs:subClassOf obo:HP_0001595, obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000535 obo:IAO_0100001 obo:HP_0045074, obo:HP_0045075 ; oboInOwl:id "HP:0000535" ; a owl:Class ; rdfs:label "obsolete Sparse and thin eyebrow" ; owl:deprecated true . obo:HP_0000537 obo:IAO_0000115 "A fold of skin starting at or just below the medial aspect of the lower lid and arching upward to cover, extend in front of and lateral to the medial canthus." ; oboInOwl:hasDbXref "SNOMEDCT_US:400956000", "UMLS:C1303003" ; oboInOwl:id "HP:0000537" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Epicanthus inversus" ; rdfs:subClassOf obo:HP_0000286 . obo:HP_0000538 obo:IAO_0000115 "Apparent optic disc swelling in the absence of increased intracranial pressure." ; oboInOwl:hasDbXref "MSH:C562401", "SNOMEDCT_US:57138009", "UMLS:C0155300" ; oboInOwl:id "HP:0000538" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Papilledema is disc edema secondary to increased intracranial pressure." ; rdfs:label "Pseudopapilledema" ; rdfs:subClassOf obo:HP_0012795 . obo:HP_0000539 obo:IAO_0000115 "An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina." ; oboInOwl:hasDbXref "UMLS:C4025843" ; oboInOwl:id "HP:0000539" ; a owl:Class ; rdfs:label "Abnormality of refraction" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0000540 obo:IAO_0000115 "An abnormality of refraction characterized by the ability to see objects in the distance clearly, while objects nearby appear blurry." ; oboInOwl:hasDbXref "MSH:D006956", "SNOMEDCT_US:38101003", "UMLS:C0020490" ; oboInOwl:hasExactSynonym "Farsightedness", "Hyperopia", "Long-sightedness" ; oboInOwl:id "HP:0000540" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The American Optometric Association subdivides hypermetropia into (i) low (up to +2D), moderate (2 to 5D), and high (over 5D)." ; rdfs:label "Hypermetropia" ; rdfs:subClassOf obo:HP_0000539 . obo:HP_0000541 obo:IAO_0000115 "Separation of the inner layers of the retina (neural retina) from the pigment epithelium." ; oboInOwl:hasAlternativeId "HP:0007864", "HP:0008021" ; oboInOwl:hasDbXref "MSH:D012163", "SNOMEDCT_US:42059000", "UMLS:C0035305" ; oboInOwl:hasExactSynonym "Detached retina", "Retinal detachment" ; oboInOwl:id "HP:0000541" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal detachment" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001453 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000542 obo:IAO_0000115 "Reduced ability to move the eye in the direction of the nose." ; oboInOwl:hasDbXref "UMLS:C1846463" ; oboInOwl:id "HP:0000542" ; a owl:Class ; rdfs:comment "Contraction of the medial rectus pulls the eye towards the nose (adduction or medial movement)." ; rdfs:label "Impaired ocular adduction" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0000543 obo:IAO_0000115 "A pale yellow discoloration of the optic disk (the area of the optic nerve head in the retina). The optic disc normally has a pinkish hue with a central yellowish depression." ; oboInOwl:hasAlternativeId "HP:0001148", "HP:0001484" ; oboInOwl:hasDbXref "SNOMEDCT_US:302200001", "UMLS:C0554970" ; oboInOwl:hasExactSynonym "Pale optic disc", "Pale optic disk" ; oboInOwl:hasRelatedSynonym "Disc pallor", "Pale optic discs" ; oboInOwl:id "HP:0000543" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Optic disc pallor can be judged clinically with serial color photographs or by comparison to the other eye. The pallor reflects replacement of dead axons by glial tissue. The loss of the small capillaries within the nerve accounts for the shift from orange-pink to white." ; rdfs:label "Optic disc pallor" ; rdfs:subClassOf obo:HP_0012795 . obo:HP_0000544 obo:IAO_0000115 "Paralysis of the external ocular muscles." ; oboInOwl:hasAlternativeId "HP:0007762" ; oboInOwl:hasDbXref "MSH:D009886", "MSH:D017246", "SNOMEDCT_US:19373007", "SNOMEDCT_US:46252003", "UMLS:C0162292", "UMLS:C0162674" ; oboInOwl:hasExactSynonym "CPEO", "Chronic progressive external ophthalmoplegia", "Ophthalmoplegia externa", "Paralysis or weakness of muscles within or surrounding outer part of eye", "Progressive paralysis or weakness of muscles of eye motility", "Progressive paralysis or weakness of muscles of eye movement" ; oboInOwl:id "HP:0000544" ; a owl:Class ; rdfs:label "External ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 . obo:HP_0000545 obo:IAO_0000115 "An abnormality of refraction characterized by the ability to see objects nearby clearly, while objects in the distance appear blurry." ; oboInOwl:hasAlternativeId "HP:0001110", "HP:0007847", "HP:0008012" ; oboInOwl:hasDbXref "MSH:D009216", "SNOMEDCT_US:57190000", "UMLS:C0027092" ; oboInOwl:hasExactSynonym "Close sighted", "Near sighted", "Near sightedness", "Nearsightedness" ; oboInOwl:id "HP:0000545" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Myopia" ; rdfs:subClassOf obo:HP_0000539 . obo:HP_0000546 obo:IAO_0000115 "A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells." ; oboInOwl:hasAlternativeId "HP:0007632", "HP:0007790", "HP:0007863", "HP:0007893" ; oboInOwl:hasDbXref "MSH:D012162", "SNOMEDCT_US:95695004", "UMLS:C0035304" ; oboInOwl:hasExactSynonym "Retina degeneration" ; oboInOwl:id "HP:0000546" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal degeneration" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000547 obo:IAO_0100001 "HP:0000510" ; oboInOwl:hasExactSynonym "Retinotapetal degeneration" ; oboInOwl:id "HP:0000547" ; a owl:Class ; rdfs:label "obsolete Tapetoretinal degeneration" ; owl:deprecated true . obo:HP_0000548 oboInOwl:hasAlternativeId "HP:0008157" ; oboInOwl:hasDbXref "MSH:D012174" ; oboInOwl:hasExactSynonym "Cone rod dystrophy", "Cone-rod retinal dystrophy" ; oboInOwl:id "HP:0000548" ; a owl:Class ; rdfs:label "Cone/cone-rod dystrophy" ; rdfs:subClassOf obo:HP_0000556 . obo:HP_0000549 obo:IAO_0000115 "Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object." ; oboInOwl:hasDbXref "UMLS:C1845274" ; oboInOwl:hasExactSynonym "Disconjugate eye movements" ; oboInOwl:id "HP:0000549" ; a owl:Class ; rdfs:label "Abnormal conjugate eye movement" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0000550 obo:IAO_0000115 "Lack of any response to stimulation upon electroretinography." ; oboInOwl:hasAlternativeId "HP:0008042" ; oboInOwl:hasDbXref "UMLS:C1855685" ; oboInOwl:hasExactSynonym "Abolished electroretinogram", "Absent electroretinogram", "Extinction of electroretinogram", "Extinguished electroretinogram", "No light-evoked response on electroretinogram", "Undetectable ERG" ; oboInOwl:id "HP:0000550" ; a owl:Class ; rdfs:label "Undetectable electroretinogram" ; rdfs:subClassOf obo:HP_0000512 . obo:HP_0000551 obo:IAO_0000115 "An anomaly in the ability to discriminate between or recognize colors." ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:23289000", "SNOMEDCT_US:367469000", "UMLS:C0009398", "UMLS:C0234629", "UMLS:C3552853" ; oboInOwl:hasExactSynonym "Abnormal color vision", "Abnormal colour vision", "Abnormality of color vision", "Abnormality of colour vision", "Colour vision defect", "Disturbed color vision", "Disturbed colour vision" ; oboInOwl:hasRelatedSynonym "Color vision defect, severe", "Color vision defects", "Colour vision defect, severe", "Colour vision defects", "Loss in color vision", "Loss in colour vision" ; oboInOwl:id "HP:0000551" ; a owl:Class ; rdfs:label "Color vision defect" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0000552 obo:IAO_0000115 "Difficulty distinguishing between yellow and blue, possible related to dysfunction of the S photopigment." ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:51886007", "SNOMEDCT_US:85049009", "UMLS:C0155017", "UMLS:C1970167" ; oboInOwl:hasExactSynonym "Blue yellow color blindness", "Blue yellow colour blindness", "Blue-yellow dyschromatopsia", "Dyschromatopsia, blue-yellow" ; oboInOwl:hasRelatedSynonym "Blue/yellow color vision defect", "Blue/yellow colour vision defect" ; oboInOwl:id "HP:0000552" ; a owl:Class ; rdfs:label "Tritanomaly" ; rdfs:subClassOf obo:HP_0011519 . obo:HP_0000553 obo:IAO_0000115 "An abnormality of the uvea, the vascular layer of the eyeball." ; oboInOwl:hasDbXref "UMLS:C4025842" ; oboInOwl:hasExactSynonym "Abnormality of the uvea" ; oboInOwl:id "HP:0000553" ; a owl:Class ; rdfs:label "Abnormal uvea morphology" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001768 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000554 obo:IAO_0000115 "Inflammation of one or all portions of the uveal tract." ; oboInOwl:hasDbXref "MSH:D014605", "SNOMEDCT_US:128473001", "UMLS:C0042164" ; oboInOwl:id "HP:0000554" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The uvea is the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid." ; rdfs:label "Uveitis" ; rdfs:subClassOf obo:HP_0000553, obo:HP_0100533 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001768 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000555 obo:IAO_0000115 "An abnormal white reflection from the pupil rather than the usual black reflection." ; oboInOwl:hasDbXref "SNOMEDCT_US:1361009", "UMLS:C0152458" ; oboInOwl:hasExactSynonym "Leukokoria", "White pupillary reflex" ; oboInOwl:id "HP:0000555" ; a owl:Class ; rdfs:comment "The word leukocoria literally means white pupil, but leukocoria is not an abnormality of the pupil. Rather, leukocoria can be caused by cataract, retinal detachment, retinopathy of prematurity, retinal malformation, endophthalmitis, retinal vascular abnormality, and intraocular tumor (e.g., retinoblastoma)." ; rdfs:label "Leukocoria" ; rdfs:subClassOf obo:HP_0000615 . obo:HP_0000556 obo:IAO_0000115 "Retinal dystrophy is an abnormality of the retina associated with a hereditary process. Retinal dystrophies are defined by their predominantly monogenic inheritance and they are frequently associated with loss or dysfunction of photoreceptor cells as a primary or secondary event." ; oboInOwl:hasAlternativeId "HP:0007736", "HP:0007910", "HP:0007974", "HP:0007982" ; oboInOwl:hasDbXref "MSH:D058499", "SNOMEDCT_US:314407005", "UMLS:C0854723" ; oboInOwl:hasExactSynonym "Breakdown of light-sensitive cells in back of eye" ; oboInOwl:id "HP:0000556" ; a owl:Class ; rdfs:label "Retinal dystrophy" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000557 obo:IAO_0000115 "Diffusely large eye (with megalocornea) associated with glaucoma." ; oboInOwl:hasDbXref "MSH:D006871", "UMLS:C4551507" ; oboInOwl:hasExactSynonym "Enlarged eyeball" ; oboInOwl:id "HP:0000557" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Buphthalmos refers to a congenital open-angle glaucoma of the eye. The term buphthalmos (from Greek 'bous' or ox and 'ophthalmos' or eye) is descriptive of an enlarged eyeglobe resulting from increased intraocular pressure. The eyeglobe is especially prone to distension in newborns and infants because its collagen filaments are not as rigid as in adults and may easily be stretched." ; rdfs:label "Buphthalmos" ; rdfs:subClassOf obo:HP_0001087, obo:HP_0001090 . obo:HP_0000558 obo:IAO_0000115 "A congenital malformation of the anterior segment characterized by iridicorneal malformation, glaucoma, iris stroma hypoplasia, posterior embryotoxon, and corneal opacities." ; oboInOwl:hasDbXref "MSH:C535679", "SNOMEDCT_US:47507006", "UMLS:C0265341" ; oboInOwl:id "HP:0000558" ; a owl:Class ; rdfs:comment "Hypoplasia (underdevelopment) of the iris as well as iris strands to the peripheral cornea." ; rdfs:label "Rieger anomaly" ; rdfs:subClassOf obo:HP_0007676 . obo:HP_0000559 oboInOwl:hasDbXref "MSH:D065306", "SNOMEDCT_US:95726001", "UMLS:C0349702" ; oboInOwl:id "HP:0000559" ; a owl:Class ; rdfs:label "Corneal scarring" ; rdfs:subClassOf obo:HP_0007957, obo:HP_0100699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001850 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000561 obo:IAO_0000115 "Lack of eyelashes." ; oboInOwl:hasAlternativeId "HP:0002288", "HP:0004516", "HP:0004539", "HP:0007926" ; oboInOwl:hasDbXref "UMLS:C1843005", "UMLS:C4280626", "UMLS:C4280627" ; oboInOwl:hasExactSynonym "Absent eyelashes", "Atrichia of eyelashes", "Failure of development of eyelashes" ; oboInOwl:hasNarrowSynonym "Agenesis of eyelashes", "Aplasia of eyelashes" ; oboInOwl:id "HP:0000561" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Often this finding is congenital and associated with alopecia universalis, but this should be coded separately." ; rdfs:label "Absent eyelashes" ; rdfs:subClassOf obo:HP_0002550, obo:HP_0200102 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000563 obo:IAO_0000115 "A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex." ; oboInOwl:hasDbXref "MSH:D007640", "SNOMEDCT_US:65636009", "UMLS:C0022578" ; oboInOwl:hasExactSynonym "Bulging cornea", "Conical cornea" ; oboInOwl:id "HP:0000563" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Keratoconus is an entity characterid by several phenotypic findings such as corneal distortion (secondary to thinning of the apex) and either Fleischer's ring or Vogt's striae. This HPO term intends to denote the finding of corneal distortion and bulge." ; rdfs:label "Keratoconus" ; rdfs:subClassOf obo:HP_0100689, obo:HP_0100692 . obo:HP_0000564 obo:IAO_0000115 "A developmental disorder of the lacrimal drainage system that most often affects the lacrimal ostium and resulting in non-opening of the nasolacrimal duct. It usually results from a non-canalization of the nasolacrimal duct." ; oboInOwl:hasAlternativeId "HP:0007729" ; oboInOwl:hasDbXref "SNOMEDCT_US:278530008", "UMLS:C0344511" ; oboInOwl:hasExactSynonym "Imperforate nasolacrimal ducts", "Nasolacrimal duct atresia", "Unopened tear duct" ; oboInOwl:id "HP:0000564" ; a owl:Class ; rdfs:label "Lacrimal duct atresia" ; rdfs:subClassOf obo:HP_0011481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000565 obo:IAO_0000115 "A form of strabismus with one or both eyes turned inward ('crossed') to a relatively severe degree, usually defined as 10 diopters or more." ; oboInOwl:hasDbXref "MSH:D004948", "SNOMEDCT_US:16596007", "UMLS:C0014877" ; oboInOwl:hasExactSynonym "Inward turning cross eyed" ; oboInOwl:id "HP:0000565" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Esotropia is analogous to but more severe thatn esophoria. Affected children are more likely to have amblyopia or require corrective eye muscle surgery than children with esophoria." ; rdfs:label "Esotropia" ; rdfs:subClassOf obo:HP_0020045, obo:HP_0032012 . obo:HP_0000567 obo:IAO_0000115 "Absence of a region of the retina, retinal pigment epithelium, and choroid." ; oboInOwl:hasAlternativeId "HP:0000611", "HP:0007718", "HP:0007784", "HP:0007956" ; oboInOwl:hasDbXref "SNOMEDCT_US:39302008", "UMLS:C0240896" ; oboInOwl:hasExactSynonym "Birth defect that causes a hole in the innermost layer at the back of the eye", "Choroidoretinal coloboma" ; oboInOwl:hasRelatedSynonym "Choroid coloboma", "Choroidal coloboma", "Coloboma of choroid" ; oboInOwl:id "HP:0000567" ; a owl:Class ; rdfs:label "Chorioretinal coloboma" ; rdfs:subClassOf obo:HP_0000532, obo:HP_0000589 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000589 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000589 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0000568 obo:IAO_0000115 "A developmental anomaly characterized by abnormal smallness of one or both eyes." ; oboInOwl:hasAlternativeId "HP:0007996" ; oboInOwl:hasBroadSynonym "Decreased size of eyeball", "Decreased size of globe of eye" ; oboInOwl:hasDbXref "Fyler:4877", "MSH:D008850", "SNOMEDCT_US:204108000", "SNOMEDCT_US:61142002", "UMLS:C0026010", "UMLS:C4280625", "UMLS:C4280808" ; oboInOwl:hasExactSynonym "Abnormally small eyeball", "Abnormally small globe of eye", "Microphthalmos" ; oboInOwl:hasRelatedSynonym "Nanophthalmos" ; oboInOwl:id "HP:0000568" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Microphthalmia" ; rdfs:subClassOf obo:HP_0008056, obo:HP_0100887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000570 obo:IAO_0000115 "An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements." ; oboInOwl:hasAlternativeId "HP:0000604" ; oboInOwl:hasDbXref "UMLS:C1842584", "UMLS:C4025841" ; oboInOwl:hasExactSynonym "Abnormality of saccadic eye movements" ; oboInOwl:hasRelatedSynonym "Impaired saccades" ; oboInOwl:id "HP:0000570" ; a owl:Class ; rdfs:comment "Fast (saccadic) eye movements comprise voluntary or involuntary refixation movements, the fast phase of vestibular nystagmus, optokinetic nystagmus, and microsaccades." ; rdfs:label "Abnormal saccadic eye movements" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0000571 obo:IAO_0000115 "Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object." ; oboInOwl:hasDbXref "SNOMEDCT_US:246768008", "UMLS:C0423082" ; oboInOwl:id "HP:0000571" ; a owl:Class ; rdfs:label "Hypometric saccades" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0000572 obo:IAO_0000115 "Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that)." ; oboInOwl:hasDbXref "SNOMEDCT_US:7973008", "UMLS:C3665386" ; oboInOwl:hasExactSynonym "Loss of vision", "Vision loss", "Visual loss" ; oboInOwl:id "HP:0000572" ; a owl:Class ; rdfs:label "Visual loss" ; rdfs:subClassOf obo:HP_0000505 . obo:HP_0000573 obo:IAO_0000115 "Hemorrhage occurring within the retina." ; oboInOwl:hasDbXref "MSH:D012166", "SNOMEDCT_US:28998008", "UMLS:C0035317" ; oboInOwl:hasExactSynonym "Retinal bleeding", "Retinal haemorrhage", "Retinal haemorrhages", "Retinal hemorrhages" ; oboInOwl:id "HP:0000573" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The type of retinal hemorrhage and its clinical appearance depends on its location within the retina." ; rdfs:label "Retinal hemorrhage" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0011885, obo:HP_0031803 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000574 obo:IAO_0000115 "Increased density/number and/or increased diameter of eyebrow hairs." ; oboInOwl:hasAlternativeId "HP:0004546" ; oboInOwl:hasDbXref "UMLS:C1853487" ; oboInOwl:hasExactSynonym "Bushy eyebrows", "Dense eyebrow", "Heavy eyebrows", "Hypertrichosis of the eyebrow", "Prominent eyebrows", "Thick eyebrow", "Thick eyebrows" ; oboInOwl:hasRelatedSynonym "Hypertrichosis of the eyebrows" ; oboInOwl:id "HP:0000574" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Thickness can be regional (medial, middle/central, lateral) or total." ; rdfs:label "Thick eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000575 obo:IAO_0000115 "A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision." ; oboInOwl:hasBroadSynonym "Blind spot" ; oboInOwl:hasDbXref "MSH:D009898", "MSH:D012607", "SNOMEDCT_US:23388006", "SNOMEDCT_US:81016008", "UMLS:C0036454", "UMLS:C0344233" ; oboInOwl:id "HP:0000575" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Scotoma" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0000576 obo:IAO_0000115 "A scotoma (area of diminished vision within the visual field) located between the central point of fixation and the blind spot with a roughly horizontal oval shape." ; oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:33014001", "UMLS:C0271196" ; oboInOwl:id "HP:0000576" ; a owl:Class ; rdfs:label "Centrocecal scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0000577 obo:IAO_0000115 "A form of strabismus with one or both eyes deviated outward." ; oboInOwl:hasAlternativeId "HP:0008033" ; oboInOwl:hasDbXref "MSH:D005099", "SNOMEDCT_US:399054005", "SNOMEDCT_US:399252000", "UMLS:C0015310" ; oboInOwl:hasExactSynonym "Outward facing eye ball" ; oboInOwl:id "HP:0000577" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Exotropia" ; rdfs:subClassOf obo:HP_0020049, obo:HP_0032012 . obo:HP_0000579 obo:IAO_0000115 "Blockage of the lacrimal duct." ; oboInOwl:hasDbXref "MSH:D007767", "SNOMEDCT_US:231841004", "SNOMEDCT_US:246865000", "SNOMEDCT_US:314022009", "SNOMEDCT_US:416920000", "UMLS:C0022906", "UMLS:C1281931" ; oboInOwl:hasExactSynonym "Blocked tear duct", "Lacrimal duct obstruction" ; oboInOwl:id "HP:0000579" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Nasolacrimal duct obstruction" ; rdfs:subClassOf obo:HP_0011481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000580 obo:IAO_0000115 "An abnormality of the retina characterized by pigment deposition. It is typically associated with migration and proliferation of macrophages or retinal pigment epithelial cells into the retina; melanin from these cells causes the pigmentary changes. Pigmentary retinopathy is a common final pathway of many retinal conditions and is often associated with visual loss." ; oboInOwl:hasAlternativeId "HP:0001146", "HP:0007702", "HP:0007821", "HP:0007852", "HP:0007869", "HP:0007934", "HP:0007961", "HP:0008010" ; oboInOwl:hasDbXref "MSH:D012174", "SNOMEDCT_US:28835009", "UMLS:C0035334" ; oboInOwl:hasExactSynonym "Pigmentary retinal deposits", "Retinal pigment clumping", "Retinal pigmentary clumping", "Retinal pigmentary degeneration" ; oboInOwl:id "HP:0000580" ; a owl:Class ; rdfs:label "Pigmentary retinopathy" ; rdfs:subClassOf obo:HP_0007703 . obo:HP_0000581 obo:IAO_0000115 "A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures." ; oboInOwl:hasAlternativeId "HP:0000507", "HP:0000513" ; oboInOwl:hasDbXref "MSH:D016569", "UMLS:C0005744" ; oboInOwl:hasExactSynonym "Decreased width of palpebral fissure", "Narrow opening between the eyelids" ; oboInOwl:id "HP:0000581" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "When the palpebral fissures are severely shortened, they cannot be widely separated, actively or passively. Blepharophimosis is an acknowledged bundled term (short vertical and horizontal distance). When palpebral fissures are severely shortened, they cannot be widely separated, actively or passively. Ptosis is the term to be used when the reduction in eyelid opening is not fixed but can be increased actively or passively. Blepharophimosis is often associated with Epicanthus inversus." ; rdfs:label "Blepharophimosis" ; rdfs:subClassOf obo:HP_0200007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040030 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000582 obo:IAO_0000115 "The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age." ; oboInOwl:hasDbXref "SNOMEDCT_US:246799009", "UMLS:C0423109" ; oboInOwl:hasExactSynonym "Mongoloid slant", "Upslanting palpebral fissures", "Upward slanted palpebral fissures", "Upward slanting of palpebral fissures", "Upward slanting of the opening between the eyelids", "Upward slanting palpebral fissures" ; oboInOwl:hasRelatedSynonym "Upslanted palpebral fissures" ; oboInOwl:id "HP:0000582" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Upslanted palpebral fissure" ; rdfs:subClassOf obo:HP_0200006 . obo:HP_0000584 oboInOwl:hasDbXref "UMLS:C1832170" ; oboInOwl:id "HP:0000584" ; a owl:Class ; rdfs:label "Punctate corneal epithelial erosions" ; rdfs:subClassOf obo:HP_0200020 . obo:HP_0000585 obo:IAO_0000115 "An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea, leading to decreased vision, foreign body sensation, and ocular irritation." ; oboInOwl:hasDbXref "MSH:C562399", "SNOMEDCT_US:35055000", "UMLS:C0155120" ; oboInOwl:hasExactSynonym "Calcific band keratopathy" ; oboInOwl:id "HP:0000585" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Band keratopathy" ; rdfs:subClassOf obo:HP_0011493 . obo:HP_0000586 obo:IAO_0000115 "Reduced depth of the orbits associated with prominent-appearing ocular globes." ; oboInOwl:hasAlternativeId "HP:0002706" ; oboInOwl:hasDbXref "UMLS:C1865244" ; oboInOwl:hasExactSynonym "Decreased depth of eye sockets", "Decreased depth of orbits", "Shallow eye sockets", "Small shallow orbits" ; oboInOwl:id "HP:0000586" ; a owl:Class ; rdfs:label "Shallow orbits" ; rdfs:subClassOf obo:HP_0000520, obo:HP_3000030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001472 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000587 obo:IAO_0000115 "Abnormality of the optic nerve." ; oboInOwl:hasDbXref "UMLS:C0029131" ; oboInOwl:hasExactSynonym "Abnormality of the optic nerve", "Optic nerve issue", "optic nerve abnormalities" ; oboInOwl:id "HP:0000587" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The optic nerve, which is also known as cranial nerve II, transmits visual information from the retina to the brain. The term 'optic disc' is frequently used to describe the portion of the optic nerve clinically visible on fundoscopic examination." ; rdfs:label "Abnormal optic nerve morphology" ; rdfs:subClassOf obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000588 obo:IAO_0000115 "A cleft of the optic nerve that extends inferiorly." ; oboInOwl:hasAlternativeId "HP:0007997" ; oboInOwl:hasDbXref "MSH:C535970", "SNOMEDCT_US:17541006", "SNOMEDCT_US:44295002", "UMLS:C0155299" ; oboInOwl:hasExactSynonym "Coloboma of optic nerve", "Optic disk coloboma", "Optic nerve coloboma" ; oboInOwl:id "HP:0000588" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A congenital, unilateral or bilateral congenital condition caused by incomplete closure of the embryonic fissure." ; rdfs:label "Optic disc coloboma" ; rdfs:subClassOf obo:HP_0000589, obo:HP_0012795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000589 obo:IAO_0000115 "A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa." ; oboInOwl:hasAlternativeId "HP:0007767", "HP:0007995" ; oboInOwl:hasDbXref "Fyler:4311", "MSH:D003103", "SNOMEDCT_US:92828000", "SNOMEDCT_US:93390002", "UMLS:C0009363" ; oboInOwl:hasExactSynonym "Notched pupil", "Ocular coloboma", "Ocular colobomas" ; oboInOwl:id "HP:0000589" ; a owl:Class ; rdfs:label "Coloboma" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000590 obo:IAO_0000115 "Initial bilateral ptosis followed by limitation of eye movements in all directions and slowing of saccades." ; oboInOwl:hasAlternativeId "HP:0000562" ; oboInOwl:hasDbXref "MSH:D017246", "SNOMEDCT_US:46252003", "UMLS:C0162674" ; oboInOwl:hasExactSynonym "External ophthalmoplegia, progressive" ; oboInOwl:id "HP:0000590" ; a owl:Class ; rdfs:comment "Progressive external ophthalmoplegia (PEO) can be regarded as a diagnosis, or as a feature of several other syndromes. The latter is the meaning of this term." ; rdfs:label "Progressive external ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000544 . obo:HP_0000591 obo:IAO_0000115 "An abnormality of the sclera." ; oboInOwl:hasBroadSynonym "Abnormality of the outer white part of eyeball" ; oboInOwl:hasDbXref "UMLS:C4025840" ; oboInOwl:hasExactSynonym "Abnormality of the sclera" ; oboInOwl:id "HP:0000591" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal sclera morphology" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001773 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000592 obo:IAO_0000115 "An abnormal bluish coloration of the sclera." ; oboInOwl:hasBroadSynonym "Blue outer white part of eyeball" ; oboInOwl:hasDbXref "SNOMEDCT_US:204164000", "UMLS:C0542514" ; oboInOwl:hasExactSynonym "Blue sclera", "Bluish sclerae", "Gray sclerae", "Grey sclerae", "Whites of eyes are a bluish-gray color", "Whites of eyes are a bluish-gray colour" ; oboInOwl:id "HP:0000592" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Blue sclerae" ; rdfs:subClassOf obo:HP_0000591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001773 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000593 obo:IAO_0000115 "Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris." ; oboInOwl:hasDbXref "SNOMEDCT_US:204142009", "UMLS:C3152182" ; oboInOwl:hasExactSynonym "Abnormality of the anterior chamber", "Anterior chamber anomalies", "Ocular anterior chamber abnormality" ; oboInOwl:id "HP:0000593" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal anterior chamber morphology" ; rdfs:subClassOf obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000594 obo:IAO_0000115 "Reduced depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is decreased." ; oboInOwl:hasAlternativeId "HP:0007756" ; oboInOwl:hasDbXref "SNOMEDCT_US:246986004", "UMLS:C0423276" ; oboInOwl:id "HP:0000594" ; a owl:Class ; rdfs:label "Shallow anterior chamber" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0000597 obo:IAO_0000115 "Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement." ; oboInOwl:hasAlternativeId "HP:0007701", "HP:0008044" ; oboInOwl:hasDbXref "MSH:D009886", "UMLS:C0751401" ; oboInOwl:hasExactSynonym "Extraocular muscle palsy", "Extraocular muscle paralysis", "Weakness of extraocular eye movement", "Weakness of muscles controlling eye movement" ; oboInOwl:id "HP:0000597" ; a owl:Class ; rdfs:label "Ophthalmoparesis" ; rdfs:subClassOf obo:HP_0000496 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0000602 obo:HP_0007715 ) ] ] . obo:HP_0000598 obo:IAO_0000115 "An abnormality of the ear." ; oboInOwl:hasDbXref "SNOMEDCT_US:275259005", "UMLS:C0266589" ; oboInOwl:hasExactSynonym "Abnormality of the ear", "Ear anomaly" ; oboInOwl:id "HP:0000598" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Either a morphological abnormality or hearing deficit. This should be split more cleanly in the future." ; rdfs:label "Abnormality of the ear" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000599 obo:IAO_0000115 "An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T05:34:00Z" ; oboInOwl:hasDbXref "UMLS:C4025839" ; oboInOwl:hasExactSynonym "Abnormality of hairline at front of head", "Abnormality of the frontal hairline" ; oboInOwl:id "HP:0000599" ; a owl:Class ; rdfs:label "Abnormality of the frontal hairline" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0009553 . obo:HP_0000600 obo:IAO_0000115 "An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly." ; oboInOwl:hasDbXref "UMLS:C4025838" ; oboInOwl:id "HP:0000600" ; a owl:Class ; rdfs:comment """The pharynx is tubular structure extending from base of skull superiorly to esophageal inlet inferiorly, and is composed of three distinct areas: the nasopharynx, the oropharynx, and the hypopharynx, with the pharyngeal walls being composed of the superior, middle, and inferior pharyngeal constrictor muscles. It is part of the digestive system and of the conducting zone of the respiratory system.""" ; rdfs:label "Abnormality of the pharynx" ; rdfs:subClassOf obo:HP_0002087 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000601 obo:IAO_0000115 "Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes)." ; oboInOwl:hasAlternativeId "HP:0007877" ; oboInOwl:hasDbXref "SNOMEDCT_US:44593008", "UMLS:C0424711" ; oboInOwl:hasExactSynonym "Abnormally close eyes", "Closely spaced eyes", "Decreased distance between eye sockets", "Decreased distance between eyes", "Decreased interpupillary distance", "Decreased orbital separation", "Ocular hypotelorism" ; oboInOwl:id "HP:0000601" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypotelorism" ; rdfs:subClassOf obo:HP_0100886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010222 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000602 obo:IAO_0000115 "Paralysis of one or more extraocular muscles that are responsible for eye movements." ; oboInOwl:hasDbXref "MSH:D009886", "SNOMEDCT_US:16110005", "UMLS:C0029089" ; oboInOwl:hasExactSynonym "Eye muscle paralysis", "Paralysis of extraocular eye movement" ; oboInOwl:id "HP:0000602" ; a owl:Class ; rdfs:label "Ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000603 obo:IAO_0000115 "An area of depressed vision located at the point of fixation and that interferes with central vision." ; oboInOwl:hasBroadSynonym "Blind spot located at fixation point" ; oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:38950008", "UMLS:C0152191", "UMLS:C4280624" ; oboInOwl:hasExactSynonym "Central blind spot", "Central scotomata" ; oboInOwl:id "HP:0000603" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Central scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0000605 obo:IAO_0000115 "A supranuclear gaze palsy is an inability to look in a particular direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:420675003", "UMLS:C1720037" ; oboInOwl:hasExactSynonym "Supranuclear gaze paralysis" ; oboInOwl:id "HP:0000605" ; a owl:Class ; rdfs:label "Supranuclear gaze palsy" ; rdfs:subClassOf obo:HP_0000549 . obo:HP_0000606 obo:IAO_0000115 "An abnormality of the region situated around the orbit of the eye." ; oboInOwl:hasDbXref "UMLS:C4025837" ; oboInOwl:hasNarrowSynonym "Abnormality of the region around the eye", "Abnormality of the region around the eye socket", "Anomaly of the periorbital region", "Deformity of the periorbital region", "Malformation of the periorbital region" ; oboInOwl:id "HP:0000606" ; a owl:Class ; rdfs:label "Abnormality of the periorbital region" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000607 oboInOwl:hasDbXref "UMLS:C1844605" ; oboInOwl:hasExactSynonym "Excess periorbital skin wrinkling", "Periorbital rhytids", "Periorbital wrinkling", "Wrinkles around the eyes" ; oboInOwl:id "HP:0000607" ; a owl:Class ; rdfs:label "Periorbital wrinkles" ; rdfs:subClassOf obo:HP_0000606, obo:HP_0100678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001810 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016462 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000608 obo:IAO_0000115 "A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea." ; oboInOwl:hasAlternativeId "HP:0007694", "HP:0007868" ; oboInOwl:hasDbXref "SNOMEDCT_US:422338006", "UMLS:C0024437" ; oboInOwl:hasExactSynonym "Pigmented macular degeneration" ; oboInOwl:id "HP:0000608" ; a owl:Class ; rdfs:label "Macular degeneration" ; rdfs:subClassOf obo:HP_0000546, obo:HP_0001103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000609 obo:IAO_0000115 "Underdevelopment of the optic nerve." ; oboInOwl:hasAlternativeId "HP:0007273" ; oboInOwl:hasDbXref "SNOMEDCT_US:95499004", "UMLS:C0338502" ; oboInOwl:hasExactSynonym "Hypoplastic optic nerves", "Underdeveloped optic nerves" ; oboInOwl:id "HP:0000609" ; a owl:Class ; rdfs:label "Optic nerve hypoplasia" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0008058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000610 obo:IAO_0000115 "Any structural abnormality of the choroid." ; oboInOwl:hasAlternativeId "HP:0001122" ; oboInOwl:hasDbXref "MSH:D015862", "UMLS:C0008521", "UMLS:C4025836" ; oboInOwl:hasExactSynonym "Abnormality of the choroid" ; oboInOwl:hasRelatedSynonym "Choroid disease" ; oboInOwl:id "HP:0000610" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal choroid morphology" ; rdfs:subClassOf obo:HP_0000553, obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000611 obo:IAO_0100001 "HP:0000567" ; oboInOwl:id "HP:0000611" ; a owl:Class ; rdfs:label "obsolete Choroid coloboma" ; owl:deprecated true . obo:HP_0000612 obo:IAO_0000115 "A coloboma of the iris." ; oboInOwl:hasAlternativeId "HP:0007744", "HP:0007748" ; oboInOwl:hasDbXref "UMLS:C0240063" ; oboInOwl:hasExactSynonym "Cat eye", "Coloboma of iris", "Coloboma of the iris", "Keyhole iris" ; oboInOwl:id "HP:0000612" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Iris coloboma" ; rdfs:subClassOf obo:HP_0000525, obo:HP_0000589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000613 obo:IAO_0000115 "Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "MSH:D020795", "SNOMEDCT_US:246622003", "SNOMEDCT_US:409668002", "UMLS:C0085636", "UMLS:C4020887" ; oboInOwl:hasExactSynonym "Extreme sensitivity of the eyes to light", "Light hypersensitivity", "Photodysphoria" ; oboInOwl:id "HP:0000613" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that the term photodysphoria is used to describe extreme photophobia." ; rdfs:label "Photophobia" ; rdfs:subClassOf obo:HP_0000504, obo:HP_5200058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001698 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000614 obo:IAO_0000115 "An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity." ; oboInOwl:hasDbXref "UMLS:C4025835" ; oboInOwl:hasExactSynonym "Abnormality of the nasolacrimal system" ; oboInOwl:id "HP:0000614" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The nasolacrimal system consists of the puncta, canaliculi, lacrimal sac, and nasolacrimal duct." ; rdfs:label "Abnormal nasolacrimal system morphology" ; rdfs:subClassOf obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000615 obo:IAO_0000115 "An abnormality of the pupil." ; oboInOwl:hasAlternativeId "HP:0008018", "HP:0030960" ; oboInOwl:hasDbXref "SNOMEDCT_US:274093008", "UMLS:C0154936" ; oboInOwl:hasExactSynonym "Abnormal pupillary morphology", "Abnormality of the pupil", "Pupillary abnormalities", "Pupillary abnormality" ; oboInOwl:id "HP:0000615" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal pupil morphology" ; rdfs:subClassOf obo:HP_0000525 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000616 obo:IAO_0000115 "Abnormal (non-physiological) constriction of the pupil." ; oboInOwl:hasDbXref "MSH:D015877", "SNOMEDCT_US:63251006", "UMLS:C0026205" ; oboInOwl:hasExactSynonym "Constricted pupils", "Pupillary constriction" ; oboInOwl:id "HP:0000616" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Miosis" ; rdfs:subClassOf obo:HP_0007686 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000617 obo:IAO_0000115 "An abnormality of eye movement characterized by impaired smooth-pursuit eye movements." ; oboInOwl:hasAlternativeId "HP:0007671", "HP:0008006" ; oboInOwl:hasDbXref "UMLS:C1836393" ; oboInOwl:hasExactSynonym "Abnormal smooth pursuits", "Disrupted ocular pursuit movements", "Impaired smooth pursuit ocular movements", "Irregular visual pursuit movements" ; oboInOwl:id "HP:0000617" ; a owl:Class ; rdfs:comment "Tracking eye movements consist of two different components, namely, smooth pursuit and saccades. Smooth pursuit, or just pursuit, is a class of rather slow eye movements that minimizes retinal target motion. Saccades are rapid eye movements that align the fovea with the target. Slow-pursuit eye movements are involved in tracking a slowly moving target after the saccadic system has placed the image of the target on the fovea." ; rdfs:label "Abnormality of ocular smooth pursuit" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0000618 obo:IAO_0000115 "Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degrees in radius around central fixation." ; oboInOwl:hasAlternativeId "HP:0007839" ; oboInOwl:hasDbXref "Fyler:4866", "MSH:D001766", "SNOMEDCT_US:65956007", "UMLS:C0271215", "UMLS:C0456909" ; oboInOwl:hasExactSynonym "Blindness", "Total vision loss" ; oboInOwl:hasRelatedSynonym "Legal blindness" ; oboInOwl:id "HP:0000618" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Various scales have been developed to describe the extent of vision loss and define blindness. Total blindness is the complete lack of form and visual light perception and is clinically recorded as NLP (no light perception). Blindness is frequently used to describe severe visual impairment with residual vision. Those described as having only light perception have no more sight than the ability to tell light from dark and the general direction of a light source." ; rdfs:label "Blindness" ; rdfs:subClassOf obo:HP_0007663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000619 obo:IAO_0000115 "Reduced ability to turn the eyes inward in order to focus on a nearby object." ; oboInOwl:hasDbXref "MSH:D015835", "SNOMEDCT_US:194131002", "UMLS:C0271379" ; oboInOwl:hasExactSynonym "Convergence insufficiency" ; oboInOwl:id "HP:0000619" ; a owl:Class ; rdfs:comment "Vergence alters the angle between the two eyes to adjust for changes in distance from the visual target." ; rdfs:label "Impaired convergence" ; rdfs:subClassOf obo:HP_0000549 . obo:HP_0000620 obo:IAO_0000115 "Inflammation of the nasolacrimal sac." ; oboInOwl:hasDbXref "MSH:D003607", "SNOMEDCT_US:85777005", "UMLS:C0010930" ; oboInOwl:hasExactSynonym "Dacrocystitis", "Infection of the lacrimal sac" ; oboInOwl:id "HP:0000620" ; a owl:Class ; rdfs:comment "Dacrocystitis is frequently caused by nasolacrimal duct obstruction or infection, which often results from stagnation of tears in a pathologically closed lacrimal drainage system. Note also that dacryocystistis has often been misspelled as dacrocystitis in the literature, but the correct spelling is dacryocystitis." ; rdfs:label "Dacryocystitis" ; rdfs:subClassOf obo:HP_0000614 . obo:HP_0000621 obo:IAO_0000115 "An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital." ; oboInOwl:hasBroadSynonym "Eyelid folded in" ; oboInOwl:hasDbXref "MSH:D004774", "SNOMEDCT_US:33168009", "UMLS:C0014390" ; oboInOwl:hasExactSynonym "Eyelid turned in" ; oboInOwl:hasRelatedSynonym "Inverted eyelid" ; oboInOwl:id "HP:0000621" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The inward turned eyelid margin increases the potential for mechanical irritation of the eye by eyelashes. Entropion is to be distinguished from epiblepharon." ; rdfs:label "Entropion" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0000622 obo:IAO_0000115 "Lack of sharpness of vision resulting in the inability to see fine detail." ; oboInOwl:hasAlternativeId "HP:0007723" ; oboInOwl:hasDbXref "SNOMEDCT_US:111516008", "SNOMEDCT_US:246636008", "UMLS:C0344232" ; oboInOwl:hasExactSynonym "Blurred vision" ; oboInOwl:id "HP:0000622" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is a very nonspecific term and it is preferable to describe the correlates of blurred vision with the corresponding terms if possible." ; rdfs:label "Blurred vision" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0000623 obo:IAO_0000115 "A vertical gaze palsy with inability to direct the gaze of the eyes downwards." ; oboInOwl:hasDbXref "UMLS:C1408507" ; oboInOwl:id "HP:0000623" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Supranuclear ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 . obo:HP_0000625 obo:IAO_0000115 "A short discontinuity of the margin of the lower or upper eyelid." ; oboInOwl:hasDbXref "SNOMEDCT_US:95202004", "UMLS:C0521573" ; oboInOwl:hasExactSynonym "Cleft eyelid", "Full thickness defect of the eyelid", "Notched eyelid" ; oboInOwl:id "HP:0000625" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The lateral segment of the lower eyelid is most commonly involved. As the milder forms of this finding are clearly subjective and no boundary of subjective and objective is defined, the term is considered subjective. The term eyelid coloboma has been replaced because the word coloboma should be used only for defects at the site of fusion of embryologic structures, which is not the case here. Modifiers to designate the location of the cleft may be added, such as lower and lateral." ; rdfs:label "Eyelid coloboma" ; rdfs:subClassOf obo:HP_0011226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000627 obo:IAO_0000115 "A posterior embryotoxon is the presence of a prominent and anteriorly displaced line of Schwalbe." ; oboInOwl:hasAlternativeId "HP:0100740" ; oboInOwl:hasDbXref "SNOMEDCT_US:253228006", "SNOMEDCT_US:392437005", "UMLS:C0344531", "UMLS:C0546967" ; oboInOwl:hasExactSynonym "Embryotoxon" ; oboInOwl:id "HP:0000627" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Schwalbe's line is the anatomical line found on the interior surface of the cornea, and delineates the outer limit of the corneal endothelium layer. Specifically, it represents the termination of Descemet's membrane. Up to 30% of the population has posterior embryotoxon as an isolated normal variant." ; rdfs:label "Posterior embryotoxon" ; rdfs:subClassOf obo:HP_0008048 . obo:HP_0000629 obo:IAO_0000115 "Increase in periorbital soft tissue." ; oboInOwl:hasDbXref "UMLS:C1858036" ; oboInOwl:hasExactSynonym "Periorbital puffiness", "Periorbital swelling", "Puffiness around eye", "Puffy eyes", "Swelling around the eyes" ; oboInOwl:hasNarrowSynonym "Fullness around the eyes" ; oboInOwl:id "HP:0000629" ; a owl:Class ; rdfs:label "Periorbital fullness" ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0000630 oboInOwl:hasDbXref "UMLS:C4021802" ; oboInOwl:hasExactSynonym "Abnormality of retinal arteries", "Retinal arterial abnormality" ; oboInOwl:id "HP:0000630" ; a owl:Class ; rdfs:label "Abnormal retinal artery morphology" ; rdfs:subClassOf obo:HP_0008046, obo:HP_0011004, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000631 obo:IAO_0000115 "The presence of an increased number of twists and turns of the retinal artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:247123003", "UMLS:C0423401" ; oboInOwl:hasExactSynonym "Retinal artery tortuousity" ; oboInOwl:id "HP:0000631" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal arterial tortuosity" ; rdfs:subClassOf obo:HP_0000630, obo:HP_0005116, obo:HP_0012841 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005116 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000632 obo:IAO_0000115 "Abnormality of tear production." ; oboInOwl:hasAlternativeId "HP:0000521" ; oboInOwl:hasDbXref "UMLS:C4021801" ; oboInOwl:hasExactSynonym "Abnormality of tear production" ; oboInOwl:id "HP:0000632" ; a owl:Class ; rdfs:label "Lacrimation abnormality" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0000633 obo:IAO_0000115 "Abnormally decreased lacrimation, that is, reduced ability to produce tears." ; oboInOwl:hasDbXref "UMLS:C0235857" ; oboInOwl:hasExactSynonym "Decreased tear secretion" ; oboInOwl:id "HP:0000633" ; a owl:Class ; rdfs:label "Decreased lacrimation" ; rdfs:subClassOf obo:HP_0000632 . obo:HP_0000634 obo:IAO_0000115 "An impaired ability of the eye to move in the outward direction (towards the side of the head)." ; oboInOwl:hasDbXref "UMLS:C1846462" ; oboInOwl:id "HP:0000634" ; a owl:Class ; rdfs:label "Impaired ocular abduction" ; rdfs:subClassOf obo:HP_0011347 . obo:HP_0000635 obo:IAO_0000115 "A markedly blue coloration of the iris." ; oboInOwl:hasDbXref "SNOMEDCT_US:301952009", "UMLS:C0578626" ; oboInOwl:hasExactSynonym "Blue eyes" ; oboInOwl:id "HP:0000635" ; a owl:Class ; rdfs:label "Blue irides" ; rdfs:subClassOf obo:HP_0008034 . obo:HP_0000636 obo:IAO_0000115 "A short discontinuity of the margin of the upper eyelid." ; oboInOwl:hasDbXref "UMLS:C1863872" ; oboInOwl:hasExactSynonym "Cleft upper eyelid", "Coloboma of the upper eyelid", "Full thickness defect of the upper eyelid", "Notched upper eyelid", "Upper eyelid colobomas" ; oboInOwl:id "HP:0000636" ; a owl:Class ; rdfs:label "Upper eyelid coloboma" ; rdfs:subClassOf obo:HP_0000625 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001712 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000637 obo:IAO_0000115 "Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures." ; oboInOwl:hasAlternativeId "HP:0007904" ; oboInOwl:hasDbXref "UMLS:C1849340" ; oboInOwl:hasExactSynonym "Broad opening between the eyelids", "Broad palpebral fissure", "Long opening between the eyelids", "Long palpebral fissures", "Wide opening between the eyelids", "Wide palpebral fissure", "Wide palpebral fissures" ; oboInOwl:id "HP:0000637" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long palpebral fissure" ; rdfs:subClassOf obo:HP_0200007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000639 obo:IAO_0000115 "Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:563001", "UMLS:C0028738" ; oboInOwl:hasExactSynonym "Involuntary, rapid, rhythmic eye movements" ; oboInOwl:id "HP:0000639" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Nystagmus" ; rdfs:subClassOf obo:HP_0012547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000417 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000640 obo:IAO_0000115 "Nystagmus made apparent by looking to the right or to the left." ; oboInOwl:hasDbXref "MSH:D009760", "SNOMEDCT_US:29356006", "UMLS:C0271390" ; oboInOwl:id "HP:0000640" ; a owl:Class ; rdfs:label "Gaze-evoked nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0000641 obo:IAO_0000115 "The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results." ; oboInOwl:hasDbXref "UMLS:C1836392" ; oboInOwl:hasExactSynonym "Dysmetric eye movements", "Dysmetric eye saccades", "Uncoordinated eye movement" ; oboInOwl:id "HP:0000641" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dysmetric saccades" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0000642 obo:IAO_0000115 "Difficulty with discriminating red and green hues." ; oboInOwl:hasAlternativeId "HP:0007960" ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:246674000", "SNOMEDCT_US:77479002", "UMLS:C0155016", "UMLS:C1970168" ; oboInOwl:hasExactSynonym "Dyschromatopsia with red-green confusion", "Red green color blindness", "Red green colour blindness" ; oboInOwl:hasRelatedSynonym "Red/green color vision defect", "Red/green colour vision defect" ; oboInOwl:id "HP:0000642" ; a owl:Class ; rdfs:label "Red-green dyschromatopsia" ; rdfs:subClassOf obo:HP_0007641 . obo:HP_0000643 obo:IAO_0000115 "A focal dystonia that affects the muscles of the eyelids and brow, associated with involuntary recurrent spasm of both eyelids." ; oboInOwl:hasAlternativeId "HP:0007907" ; oboInOwl:hasDbXref "MSH:D001764", "SNOMEDCT_US:59026006", "UMLS:C0005747" ; oboInOwl:hasExactSynonym "Eyelid spasm", "Eyelid twitching", "Involuntary closure of eyelid", "Spontaneous closure of eyelid" ; oboInOwl:id "HP:0000643" ; a owl:Class ; rdfs:label "Blepharospasm" ; rdfs:subClassOf obo:HP_0012179, obo:HP_0031879 . obo:HP_0000646 obo:IAO_0000115 "Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways." ; oboInOwl:hasDbXref "MSH:D000550", "SNOMEDCT_US:387742006", "UMLS:C0002418" ; oboInOwl:hasExactSynonym "Lazy eye", "Wandering eye", "Wandering eyes" ; oboInOwl:id "HP:0000646" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Ambylopia can result from visual deprivation during the critical period of development of visual abilities which lasts to about the age of 8 years. Thus, ambylopia can result from strabismus, anisometropia, or high hypermetropia in there is a failure to form a focused image in one or both eyes." ; rdfs:label "Amblyopia" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0000647 obo:IAO_0000115 "A congenital anomaly in which a part or the whole of the cornea acquires the characteristics of sclera, resulting in clouding of the cornea." ; oboInOwl:hasDbXref "MSH:C565209", "UMLS:C1853235" ; oboInOwl:hasExactSynonym "Hardening of skin and connective tissue" ; oboInOwl:id "HP:0000647" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sclerocornea" ; rdfs:subClassOf obo:HP_0007957 . obo:HP_0000648 obo:IAO_0000115 "Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy." ; oboInOwl:hasAlternativeId "HP:0007751", "HP:0007855" ; oboInOwl:hasDbXref "MSH:D009896", "SNOMEDCT_US:76976005", "UMLS:C0029124" ; oboInOwl:hasExactSynonym "Optic nerve atrophy", "Optic-nerve degeneration" ; oboInOwl:id "HP:0000648" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The diagnosis of optic atrophy is made when the optic disc loses its normal orange-pink color. Optic atrophy is an end stage that arises from myriad causes of optic nerve damage anywhere along the path from the retina to the lateral geniculate. Some of the most common etiologies are advanced glaucoma, optic neuritis, arteritic or non-arteritic ischaemic optic neuropathy or a compressive lesion." ; rdfs:label "Optic atrophy" ; rdfs:subClassOf obo:HP_0012795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000649 obo:IAO_0000115 "An anomaly of visually evoked potentials (VEP), which are electrical potentials, initiated by brief visual stimuli, which are recorded from the scalp overlying the visual cortex." ; oboInOwl:hasDbXref "SNOMEDCT_US:102968003", "UMLS:C0522214" ; oboInOwl:hasExactSynonym "Abnormal vision evoked potentials", "Abnormal visual evoked potential", "Abnormal visual evoked responses", "Abnormal visual-evoked potentials", "VEP abnormalities" ; oboInOwl:id "HP:0000649" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The terms visually evoked potential (VEP), visually evoked response (VER) and visually evoked cortical potential (VECP) are equivalent." ; rdfs:label "Abnormality of visual evoked potentials" ; rdfs:subClassOf obo:HP_0030453 . obo:HP_0000650 oboInOwl:hasDbXref "UMLS:C4025834" ; oboInOwl:id "HP:0000650" ; a owl:Class ; rdfs:label "Abnormal amplitude of pattern reversal visual evoked potentials" ; rdfs:subClassOf obo:HP_0100289 . obo:HP_0000651 obo:IAO_0000115 "Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision." ; oboInOwl:hasDbXref "MSH:D004172", "SNOMEDCT_US:24982008", "UMLS:C0012569" ; oboInOwl:hasExactSynonym "Double vision" ; oboInOwl:id "HP:0000651" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Diplopia" ; rdfs:subClassOf obo:HP_0011514 . obo:HP_0000652 obo:IAO_0000115 "A short discontinuity of the margin of the lower eyelid." ; oboInOwl:hasAlternativeId "HP:0007909" ; oboInOwl:hasDbXref "UMLS:C1837826" ; oboInOwl:hasExactSynonym "Cleft lower eyelid", "Coloboma of lower eyelid", "Full thickness defect of the lower eyelid", "Lower lid coloboma", "Notched lower eyelid" ; oboInOwl:id "HP:0000652" ; a owl:Class ; rdfs:label "Lower eyelid coloboma" ; rdfs:subClassOf obo:HP_0000625 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000653 obo:IAO_0000115 "Decreased density/number of eyelashes." ; oboInOwl:hasAlternativeId "HP:0002284", "HP:0004519", "HP:0004531", "HP:0004555", "HP:0004777", "HP:0007853" ; oboInOwl:hasDbXref "UMLS:C1843300" ; oboInOwl:hasExactSynonym "Hypotrichosis of eyelashes", "Partial absence of eyelashes", "Scant eyelashes", "Scanty eyelashes", "Sparse eyelashes", "Thin eyelashes" ; oboInOwl:id "HP:0000653" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sparse eyelashes" ; rdfs:subClassOf obo:HP_0008070, obo:HP_0200102 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000654 obo:IAO_0000115 "Descreased amplitude of eletrical response upon electroretinography." ; oboInOwl:hasAlternativeId "HP:0007636", "HP:0007689", "HP:0007845" ; oboInOwl:hasDbXref "UMLS:C1839025" ; oboInOwl:hasExactSynonym "Decreased ERG amplitude", "Decreased amplitudes on flash visual electroretinogram", "Decreased electroretinogram", "Decreased electroretinogram amplitude", "Decreased electroretinogram response", "Flattened or absent electroretinogram", "Reduced ERG", "Reduced electroretinogram", "Reduced or abolished electroretinogram" ; oboInOwl:id "HP:0000654" ; a owl:Class ; rdfs:label "Decreased light- and dark-adapted electroretinogram amplitude" ; rdfs:subClassOf obo:HP_0008323 . obo:HP_0000655 obo:IAO_0100001 "HP:0007773" ; oboInOwl:id "HP:0000655" ; a owl:Class ; rdfs:label "obsolete Vitreoretinal degeneration" ; owl:deprecated true . obo:HP_0000656 obo:IAO_0000115 "An outward turning (eversion) or rotation of the eyelid margin." ; oboInOwl:hasBroadSynonym "Eyelid folded out" ; oboInOwl:hasDbXref "MSH:D004483", "SNOMEDCT_US:127559009", "SNOMEDCT_US:62909004", "UMLS:C0013592" ; oboInOwl:hasExactSynonym "Eyelid turned out" ; oboInOwl:hasRelatedSynonym "Everted eyelid" ; oboInOwl:id "HP:0000656" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Ectropion is frequently associated wit overexposure of the palpebral and scleral conjunctiva and cornea. It usually involves the lower eyelid." ; rdfs:label "Ectropion" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000657 obo:IAO_0000115 "Ocular motor apraxia is a deficiency in voluntary, horizontal, lateral, fast eye movements (saccades) with retention of slow pursuit movements. The inability to follow objects visually is often compensated by head movements. There may be decreased smooth pursuit, and cancellation of the vestibulo-ocular reflex." ; oboInOwl:hasAlternativeId "HP:0000628", "HP:0007764" ; oboInOwl:hasDbXref "MSH:C537423", "SNOMEDCT_US:193662007", "UMLS:C3489733", "UMLS:C4020886" ; oboInOwl:hasExactSynonym "Ocular motor apraxia" ; oboInOwl:hasRelatedSynonym "Defective or absent horizontal voluntary eye movements" ; oboInOwl:id "HP:0000657" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Oculomotor apraxia leads defective or absent horizontal voluntary eye movements with head thrusting to look at objects to the side as well as jerky, abnormal eye movements." ; rdfs:label "Oculomotor apraxia" ; rdfs:subClassOf obo:HP_0000496, obo:HP_0002186 . obo:HP_0000658 oboInOwl:hasDbXref "SNOMEDCT_US:423142006", "UMLS:C1142448" ; oboInOwl:hasExactSynonym "Difficulty opening the eyelids" ; oboInOwl:id "HP:0000658" ; a owl:Class ; rdfs:label "Eyelid apraxia" ; rdfs:subClassOf obo:HP_0002186, obo:HP_0031879 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000659 obo:IAO_0000115 "A form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. Peters anomaly is characterized by central, paracentral, or complete corneal opacity." ; oboInOwl:hasDbXref "MSH:C537884", "SNOMEDCT_US:204153003", "UMLS:C0344559" ; oboInOwl:id "HP:0000659" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Peters anomaly" ; rdfs:subClassOf obo:HP_0007700 . obo:HP_0000660 obo:IAO_0000115 "A creamy appearance of the retinal blood vessels that occurs when the concentration of lipids in the blood are extremely increased, with pale pink to milky white retinal vessels and altered pale reflexes from choroidal vasculature." ; oboInOwl:hasDbXref "SNOMEDCT_US:95692001", "UMLS:C0339477" ; oboInOwl:id "HP:0000660" ; a owl:Class ; rdfs:comment "Lipemia retinalis is thought to be directly correlated with the serum triglyceride level; typically, the retinal findings do not occur until the triglyceride level reaches 2500 mg per deciliter (28.2 mmol per liter)." ; rdfs:label "Lipemia retinalis" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0000661 oboInOwl:hasDbXref "UMLS:C1846465" ; oboInOwl:id "HP:0000661" ; a owl:Class ; rdfs:label "Palpebral fissure narrowing on adduction" ; rdfs:subClassOf obo:HP_0000581 . obo:HP_0000662 obo:IAO_0000115 "Inability to see well at night or in poor light." ; oboInOwl:hasAlternativeId "HP:0007653", "HP:0007725", "HP:0007865", "HP:0007895" ; oboInOwl:hasDbXref "MSH:D009755", "SNOMEDCT_US:65194006", "UMLS:C0028077", "UMLS:C4020885" ; oboInOwl:hasExactSynonym "Night blindness", "Night-blindness", "Poor night vision" ; oboInOwl:hasRelatedSynonym "Difficulties with night vision" ; oboInOwl:id "HP:0000662" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Nyctalopia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0000664 obo:IAO_0000115 "Meeting of the medial eyebrows in the midline." ; oboInOwl:hasAlternativeId "HP:0002210" ; oboInOwl:hasDbXref "SNOMEDCT_US:253207002", "UMLS:C0431447" ; oboInOwl:hasExactSynonym "Monobrow", "Synophris", "Unibrow" ; oboInOwl:id "HP:0000664" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Synophrys" ; rdfs:subClassOf obo:HP_0000534, obo:HP_0002219 . obo:HP_0000666 obo:IAO_0000115 "Nystagmus consisting of horizontal to-and-fro eye movements." ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:81756001", "UMLS:C0271385" ; oboInOwl:hasExactSynonym "Nystagmus, horizontal" ; oboInOwl:id "HP:0000666" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Horizontal nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0000667 obo:IAO_0000115 "Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease." ; oboInOwl:hasDbXref "SNOMEDCT_US:4229009", "UMLS:C0271007" ; oboInOwl:id "HP:0000667" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Phthisis bulbi refers to atrophy and degeneration of a blind eye." ; rdfs:label "Phthisis bulbi" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000668 obo:IAO_0000115 "The absence of five or less teeth from the normal series by a failure to develop." ; oboInOwl:hasDbXref "MSH:D000848", "SNOMEDCT_US:64969001", "UMLS:C0020608" ; oboInOwl:hasExactSynonym "Failure of development of between one and six teeth" ; oboInOwl:hasRelatedSynonym "Missing between one and six teeth" ; oboInOwl:id "HP:0000668" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hypodontia needs to be confirmed by X-rays. The terms hypodontia and oligodontia have been used interchangeably in literature but these define two different clinical entities. Hypodontia has been used to define exclusively the absence of permanent teeth and excluding third molars, but the absence of any deciduous and permanent teeth, including third molars, should be called hypodontia as well." ; rdfs:label "Hypodontia" ; rdfs:subClassOf obo:HP_0009804 . obo:HP_0000670 obo:IAO_0000115 "Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries." ; oboInOwl:hasAlternativeId "HP:0006295", "HP:0006306" ; oboInOwl:hasDbXref "MSH:D003731", "SNOMEDCT_US:80967001", "UMLS:C0011334", "UMLS:C4280623" ; oboInOwl:hasExactSynonym "Caries", "Cariosity of teeth", "Dental caries", "Dental cavities", "Early dental caries", "Frequent caries", "Tooth cavities", "Tooth decay" ; oboInOwl:hasRelatedSynonym "Dental decay", "Rotting teeth" ; oboInOwl:id "HP:0000670" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "It should be noted that it is not always possible to rule out environmental influences and that reports of association between hereditary diseases and susceptibility to dental caries should be regarded with caution." ; rdfs:label "Carious teeth" ; rdfs:subClassOf obo:HP_0011061 . obo:HP_0000674 obo:IAO_0000115 "The absence of all teeth from the normal series by a failure to develop." ; oboInOwl:hasAlternativeId "HP:0006484" ; oboInOwl:hasDbXref "MSH:D000848", "SNOMEDCT_US:16958000", "SNOMEDCT_US:26624006", "UMLS:C0399352", "UMLS:C4280622" ; oboInOwl:hasExactSynonym "Anodontia vera", "Complete agenesis of all teeth", "Complete dental agenesis", "Failure of development of all teeth" ; oboInOwl:hasNarrowSynonym "Complete anodontia", "Total anodontia" ; oboInOwl:hasRelatedSynonym "Missing all teeth", "Total absence of all teeth" ; oboInOwl:id "HP:0000674" ; a owl:Class ; rdfs:comment "Anodontia can affect both primary and permanent teeth. Alternatively, there can be anodontia of just the permanent teeth. Anodontia must be distinguished from non-erupted teeth." ; rdfs:label "Anodontia" ; rdfs:subClassOf obo:HP_0009804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000675 obo:IAO_0000115 "Increased size of the maxillary central secondary incisor tooth." ; oboInOwl:hasBroadSynonym "Hyperplasia of permanent maxillary central incisor", "Hypertrophy of permanent maxillary central incisor", "Increased size of permanent maxillary central incisor", "Increased size of permanent upper central incisor", "Large permanent maxillary central incisor", "Large permanent upper central incisor" ; oboInOwl:hasDbXref "UMLS:C1835095", "UMLS:C4280263", "UMLS:C4280620", "UMLS:C4280621" ; oboInOwl:hasExactSynonym "Increased width of permanent maxillary central incisor", "Increased width of permanent upper central incisor", "Long maxillary central incisors", "Prominent upper incisors", "Prominent, protruding upper incisors" ; oboInOwl:id "HP:0000675" ; a owl:Class ; rdfs:label "Macrodontia of permanent maxillary central incisor" ; rdfs:subClassOf obo:HP_0011081 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000676 obo:IAO_0000115 "An abnormality of the Incisor tooth." ; oboInOwl:hasAlternativeId "HP:0006340" ; oboInOwl:hasDbXref "UMLS:C4025833" ; oboInOwl:id "HP:0000676" ; a owl:Class ; rdfs:label "Abnormality of the incisor" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000677 obo:IAO_0000115 """The absence of six or more teeth from the normal series by a failure to develop.""" ; oboInOwl:hasAlternativeId "HP:0000702" ; oboInOwl:hasDbXref "UMLS:C4082304", "UMLS:C4280619" ; oboInOwl:hasExactSynonym "Failure of development of more than six teeth", "Partial anodontia" ; oboInOwl:hasRelatedSynonym "Missing more than six teeth", "Number of teeth decreased by more than six" ; oboInOwl:id "HP:0000677" ; a owl:Class ; rdfs:comment "The diagnosis of oligodontia requires a radiograph, as is true for anodontia and for the other designation of tooth agenesis, hypodontia. The terms hypodontia and oligodontia are sometimes used interchangeably in the literature while on other occasions hypodontia is used for selective agenesis of six or less missing teeth while oligodontia is applied when there are more than six missing teeth. Tooth agenesis or oligodontia/hypodontia can be mistaken for delayed eruption and again a radiograph is needed for diagnosis. Absence of teeth may be congenital (tooth agenesis) or acquired. The incidence of congenital absence of teeth is different depending on the type and position of the tooth [Gorlin et al, 2001]." ; rdfs:label "Oligodontia" ; rdfs:subClassOf obo:HP_0009804 . obo:HP_0000678 obo:IAO_0000115 "Changes in alignment of teeth in the dental arch" ; oboInOwl:hasBroadSynonym "Inadequate arch length for tooth size", "Tooth mass arch size discrepancy", "Tooth size discrepancy" ; oboInOwl:hasDbXref "MSH:D008310", "SNOMEDCT_US:12351004", "SNOMEDCT_US:699222000", "UMLS:C0040433", "UMLS:C1317785", "UMLS:C4280617", "UMLS:C4280618" ; oboInOwl:hasExactSynonym "Crowded teeth", "Dental crowding", "Dental overcrowding", "Overcrowding of teeth" ; oboInOwl:id "HP:0000678" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Overlapping teeth within an alveolar ridge." ; rdfs:label "Dental crowding" ; rdfs:subClassOf obo:HP_0000692 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000619 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000679 obo:IAO_0000115 "Increased volume of dental pulp of permanent molar characterized by a crown body-root ratio equal or larger than 1:1 or an elongated pulp chambers and apical displacement of the bifurcation or trifurcation of the roots." ; oboInOwl:hasDbXref "MSH:C536946", "SNOMEDCT_US:51744007", "UMLS:C0266039", "UMLS:C4280616" ; oboInOwl:hasExactSynonym "Taurodont", "Taurodontism" ; oboInOwl:hasRelatedSynonym "Large elongated pulp chamber" ; oboInOwl:id "HP:0000679" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Taurodontia causes a molar shape that is visible on radiographs. Taurodontic teeth display proportionately short roots and enlarged pulp chambers. Body of the tooth and pulp chamber is enlarged." ; rdfs:label "Taurodontia" ; rdfs:subClassOf obo:HP_0006479, obo:HP_0006486, obo:HP_0011071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013618 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000680 obo:IAO_0000115 "Delayed tooth eruption affecting the primary dentition." ; oboInOwl:hasDbXref "UMLS:C1849538" ; oboInOwl:hasExactSynonym "Delayed eruption of baby teeth", "Delayed eruption of deciduous teeth", "Delayed eruption of milk teeth", "Delayed primary teeth eruption", "Late eruption of baby teeth", "Late eruption of milk teeth", "Late eruption of primary teeth" ; oboInOwl:id "HP:0000680" ; a owl:Class ; rdfs:label "Delayed eruption of primary teeth" ; rdfs:subClassOf obo:HP_0000684, obo:HP_0006481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000684 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000682 obo:IAO_0000115 "An abnormality of the dental enamel." ; oboInOwl:hasAlternativeId "HP:0006322" ; oboInOwl:hasDbXref "UMLS:C4021800", "UMLS:C4280262", "UMLS:C4280615" ; oboInOwl:hasExactSynonym "Abnormal tooth enamel", "Abnormality of dental enamel", "Enamel abnormalities", "Enamel abnormality" ; oboInOwl:hasNarrowSynonym "Defective tooth enamel", "Dystrophic tooth enamel", "Malformation of dental enamel", "Malformation of tooth enamel" ; oboInOwl:id "HP:0000682" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The dental enamel is the external layer of the teeth, being a highly mineralized substance consisting primarily of hydroxylapatite." ; rdfs:label "Abnormal dental enamel morphology" ; rdfs:subClassOf obo:HP_0011061, obo:HP_3000050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001752 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001091 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000683 obo:IAO_0000115 "A grey discoloration of the dental enamel." ; oboInOwl:hasDbXref "UMLS:C1854783" ; oboInOwl:hasExactSynonym "Gray colored tooth enamel", "Gray tooth shade", "Grayish enamel", "Grey coloured tooth enamel", "Grey tooth shade", "Greyish enamel" ; oboInOwl:id "HP:0000683" ; a owl:Class ; rdfs:comment "Grey enamel may be seen in dentinogenesis imperfecta, but dentinogenesis imperfecta should be coded separately if present." ; rdfs:label "Grayish enamel" ; rdfs:subClassOf obo:HP_0000682, obo:HP_0011073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000950 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000684 obo:IAO_0000115 "Delayed tooth eruption, which can be defined as tooth eruption more than 2 SD beyond the mean eruption age." ; oboInOwl:hasAlternativeId "HP:0000686", "HP:0006294", "HP:0006314", "HP:0006328" ; oboInOwl:hasDbXref "SNOMEDCT_US:5639000", "UMLS:C0239174" ; oboInOwl:hasExactSynonym "Delayed dental development", "Delayed dental eruption", "Delayed eruption", "Delayed eruption of teeth", "Delayed teeth eruption", "Delayed tooth eruption", "Eruption, delayed", "Late eruption of teeth", "Late tooth eruption" ; oboInOwl:id "HP:0000684" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term should not be used in a patient with Gingival overgrowth. Eruption is defined by the appearance of a tooth that has pierced the oral mucosa. There are established norms for the timing of eruption in both deciduous and permanent teeth. Eruption delay may affect either the deciduous teeth, permanent teeth, or both. The absence of shedding of deciduous teeth may be seen in association with delayed permanent tooth eruption or agenesis of successional permanent teeth. The diagnosis eruption delayed requires clinical and radiographic examinations." ; rdfs:label "Delayed eruption of teeth" ; rdfs:subClassOf obo:HP_0006292 . obo:HP_0000685 obo:IAO_0000115 "Developmental hypoplasia of teeth." ; oboInOwl:hasAlternativeId "HP:0000688", "HP:0006281", "HP:0006307" ; oboInOwl:hasBroadSynonym "Decreased size of teeth", "Underdevelopment of teeth" ; oboInOwl:hasDbXref "UMLS:C0235357", "UMLS:C4280611" ; oboInOwl:hasExactSynonym "Hypoplastic teeth" ; oboInOwl:id "HP:0000685" ; a owl:Class ; rdfs:label "Hypoplasia of teeth" ; rdfs:subClassOf obo:HP_0011061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000687 obo:IAO_0000115 "Increased spaces (diastemata) between most of the teeth in the same dental arch." ; oboInOwl:hasDbXref "UMLS:C1844813" ; oboInOwl:hasExactSynonym "Generalised dental spacing", "Generalised spacing of teeth", "Generalized dental spacing", "Generalized spacing of teeth", "Multiple diastemata", "Wide-spaced teeth", "Widely spaced teeth", "Widely-spaced teeth" ; oboInOwl:id "HP:0000687" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Wide spacing can be secondary to increased room by an unusually large dental arch, microdontia or mixed primary and secondary dentition. It should be carefully noted that slight spacing between the primary teeth is normal, so experience in evaluation is important in determining this feature. This descriptor must be distinguished from Diastema." ; rdfs:label "Widely spaced teeth" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0000689 obo:IAO_0000115 "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." ; oboInOwl:hasDbXref "MSH:D008310", "SNOMEDCT_US:47944004", "SNOMEDCT_US:707598004", "UMLS:C0024636", "UMLS:C4280613", "UMLS:C4280614" ; oboInOwl:hasExactSynonym "Bad bite", "Bilateral crossbite", "Bilateral crossbite malocclusion", "Incorrect relation between upper and lower dental arches", "Malalignment of upper and lower dental arches", "Malocclusion", "Malocclusion of teeth", "Misalignment of upper and lower dental arches", "Occlusion anomaly" ; oboInOwl:hasNarrowSynonym "Angle class 2 malocclusion", "Angle class 3 malocclusion" ; oboInOwl:id "HP:0000689" ; a owl:Class ; rdfs:label "Dental malocclusion" ; rdfs:subClassOf obo:HP_0000692 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001654 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009680 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0009679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000690 obo:IAO_0000115 "Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor and maxillary lateral secondary incisor." ; oboInOwl:hasDbXref "UMLS:C1849950", "UMLS:C4083046" ; oboInOwl:hasExactSynonym "Absent upper lateral incisors", "Failure of development of maxillary lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of maxillary lateral incisor", "Absence of upper lateral incisor", "Missing maxillary lateral incisor", "Missing upper lateral incisor" ; oboInOwl:id "HP:0000690" ; a owl:Class ; rdfs:label "Agenesis of maxillary lateral incisor" ; rdfs:subClassOf obo:HP_0200153, obo:HP_0200160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000691 obo:IAO_0000115 "Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth." ; oboInOwl:hasBroadSynonym "Hypotrophic tooth" ; oboInOwl:hasDbXref "SNOMEDCT_US:32337007", "UMLS:C0240340", "UMLS:C4280611", "UMLS:C4280612" ; oboInOwl:hasExactSynonym "Decreased size of tooth", "Decreased width of tooth", "Small teeth", "Small tooth", "Tooth hypoplasia", "Tooth hypotrophy", "Underdeveloped tooth" ; oboInOwl:id "HP:0000691" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Standard reference has means and standard deviations by gender [Moyers et al, 1976]. It is easy to measure the width of teeth, for which reason the definition of microdontia can be made with reference to the width of the tooth. However, microdontia means that the overall size of the tooth is decreased. In microdontia, the gaps between the teeth, particularly the anterior upper and lower teeth, are increased, creating diastemata. This should be assessed and coded separately." ; rdfs:label "Microdontia" ; rdfs:subClassOf obo:HP_0006482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000692 obo:IAO_0000115 "Abnormal alignment, positioning, or spacing of the teeth, i.e., misaligned teeth." ; oboInOwl:hasAlternativeId "HP:0000693", "HP:0001569", "HP:0006303", "HP:0006478" ; oboInOwl:hasBroadSynonym "Abnormality of position of teeth" ; oboInOwl:hasDbXref "UMLS:C1852504", "UMLS:C4280610" ; oboInOwl:hasExactSynonym "Abnormal dental position", "Abnormal teeth spacing", "Abnormality of alignment of teeth", "Abnormality of teeth spacing", "Crooked teeth", "Malaligned teeth", "Malposition of teeth", "Malpositioned teeth", "Misalignment of teeth", "Teeth, malposition" ; oboInOwl:id "HP:0000692" ; a owl:Class ; rdfs:label "Tooth malposition" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001654 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000694 obo:IAO_0000115 "The diagnosis odontodysplasia requires clinical and radiological exams, in which unusually large pulp chambers and large pulp room chambers with thin enamel and dentin are visible. It may affect either a single tooth or several teeth. The term regional odontodysplasia is used if several teeth are affected. It affects the deciduous and permanent dentitions in the maxilla, the mandible or both, although the maxilla is more frequently involved. A type of dental dysplasia occurring in dentinogenesis imperfecta in which the pulp chambers are enlarged and there is a reduced amount of coronal dentin." ; oboInOwl:hasDbXref "SNOMEDCT_US:67504007", "UMLS:C2981132" ; oboInOwl:hasExactSynonym "Ghost teeth", "Shell teeth", "Teeth with dentinal dysplasia", "Teeth with thin dentin and large pulp chambers", "Teeth with type iii dentinogenesis imperfecta" ; oboInOwl:id "HP:0000694" ; a owl:Class ; rdfs:label "Odontodysplasia" ; rdfs:subClassOf obo:HP_0000703 . obo:HP_0000695 obo:IAO_0000115 "A tooth present at birth or erupting within the first month of life." ; oboInOwl:hasDbXref "MSH:D009306", "SNOMEDCT_US:21995002", "SNOMEDCT_US:58748004", "UMLS:C0027443" ; oboInOwl:hasExactSynonym "Born with teeth", "Natal teeth", "Neonatal teeth", "Teeth present at birth" ; oboInOwl:id "HP:0000695" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A tooth erupting between the second and fourth month is called a neonatal tooth. A natal tooth is uncommon, the prevalence at birth is 1/2000 to 1/3500 birth. In 85%, the erupted tooth is the deciduous lower incisors, and in 5%, it concerns upper incisors or molars, and in 10%, it involves supernumerary teeth. Natal teeth are usually mobile and lack root formation." ; rdfs:label "Natal tooth" ; rdfs:subClassOf obo:HP_0006288 . obo:HP_0000696 obo:IAO_0000115 "Delayed tooth eruption affecting the secondary dentition." ; oboInOwl:hasDbXref "UMLS:C1849540" ; oboInOwl:hasExactSynonym "Delayed eruption of adult teeth", "Delayed eruption of permanent teeth", "Delayed eruption of secondary dentition", "Delayed eruption of secondary teeth", "Delayed permanent dentition" ; oboInOwl:id "HP:0000696" ; a owl:Class ; rdfs:label "Delayed eruption of permanent teeth" ; rdfs:subClassOf obo:HP_0000684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000684 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000698 obo:IAO_0000115 "An abnormal conical form of the teeth, that is, a tooth whose sides converge or taper together incisally." ; oboInOwl:hasDbXref "SNOMEDCT_US:29553002", "UMLS:C0266037", "UMLS:C4012359" ; oboInOwl:hasExactSynonym "Cone shaped tooth", "Conoid tooth", "Peg shaped teeth", "Peg tooth", "Peg-shaped teeth", "Shark tooth" ; oboInOwl:hasRelatedSynonym "Conical teeth", "Peg shaped tooth", "Pointed tooth" ; oboInOwl:id "HP:0000698" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A conical shape of a tooth occurs in incisors and canines only. Conical teeth may occur isolated or associated with other dental anomalies, such as hypodontia and oligodontia; this should be assessed and coded separately." ; rdfs:label "Conical tooth" ; rdfs:subClassOf obo:HP_0006482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000699 obo:IAO_0000115 "Increased space between two adjacent teeth in the same dental arch." ; oboInOwl:hasBroadSynonym "Gaps between teeth" ; oboInOwl:hasDbXref "MSH:D003970", "SNOMEDCT_US:35591002", "UMLS:C0011998" ; oboInOwl:hasExactSynonym "Dental diastasis", "Dental diastema", "Diastasis of the teeth", "Diastema of the teeth", "Gap between teeth" ; oboInOwl:id "HP:0000699" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Usually there is contact between the lateral aspects of the permanent teeth, at their broadest point. Diastema can apply to any pair of teeth and the term should be modified by a descriptor of the involved teeth. This descriptor must be distinguished from Widely spaced teeth." ; rdfs:label "Diastema" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0000700 obo:IAO_0000115 "Radiolucency (reflecting a reduction in the bony substance) around the apex (the tip of the dental root)." ; oboInOwl:hasDbXref "MSH:D010484", "MSH:D011842", "SNOMEDCT_US:81407003", "SNOMEDCT_US:89988002", "UMLS:C0031029", "UMLS:C0034543", "UMLS:C1852169", "UMLS:C4280609" ; oboInOwl:hasExactSynonym "Dark spot around tooth root on x-ray", "Periapical lesion" ; oboInOwl:hasRelatedSynonym "Bone loss around tooth root", "Periapical cyst", "Periapical granuloma", "Periapical radiolucencies", "Periapical radiolucency" ; oboInOwl:id "HP:0000700" ; a owl:Class ; rdfs:comment "Periapical radiolucencies can be seen with periapical granuloma, cysts, ameloblastoma, odotogenic keratatoycsts, and other lesions." ; rdfs:label "Periapical bone loss" ; rdfs:subClassOf obo:HP_0000164 . obo:HP_0000703 obo:IAO_0000115 "Developmental dysplasia of dentin." ; oboInOwl:hasDbXref "MSH:D003811", "SNOMEDCT_US:196286005", "UMLS:C0011436" ; oboInOwl:id "HP:0000703" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term is kept for convenience since it is often used to refer to the phenotype of discolored, fragile teeth in the medical literature. Dentinogenesis imperfecta is a disorder of tooth development. This condition causes the teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent. Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss." ; rdfs:label "Dentinogenesis imperfecta" ; rdfs:subClassOf obo:HP_0010299, obo:HP_3000050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000704 obo:IAO_0000115 "Inflammation of the periodontium." ; oboInOwl:hasAlternativeId "HP:0000165", "HP:0006301" ; oboInOwl:hasBroadSynonym "Gum disease", "Periodontal disease" ; oboInOwl:hasDbXref "MSH:D005882", "MSH:D010510", "MSH:D010518", "SNOMEDCT_US:18718003", "SNOMEDCT_US:2556008", "SNOMEDCT_US:41565005", "UMLS:C0017563", "UMLS:C0031090", "UMLS:C0031099" ; oboInOwl:hasExactSynonym "Pyorrhea" ; oboInOwl:id "HP:0000704" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Periodontitis" ; rdfs:subClassOf obo:HP_0000164, obo:HP_0000168, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001758 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000705 obo:IAO_0000115 "A developmental dysplasia of the dental enamel." ; oboInOwl:hasAlternativeId "HP:0006284", "HP:0006310", "HP:0006325", "HP:0006327", "HP:0006331" ; oboInOwl:hasDbXref "MSH:D000567", "SNOMEDCT_US:78494001", "UMLS:C0002452" ; oboInOwl:id "HP:0000705" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Amelogenesis imperfecta (AI) is a term for a clinically and genetically heterogeneous group of diseases that affect the dental enamel, occasionally in conjunction with other dental, oral and extraoral tissues. This term has often been used to describe the phenotype associated with AI, but for new annotations it is recommended to describe the individual manifestations." ; rdfs:label "Amelogenesis imperfecta" ; rdfs:subClassOf obo:HP_0000682 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000706 obo:IAO_0000115 "A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential." ; oboInOwl:hasBroadSynonym "Unerupted dentition" ; oboInOwl:hasDbXref "SNOMEDCT_US:109542004", "UMLS:C1290587" ; oboInOwl:hasExactSynonym "Failure of eruption of tooth", "Pseudo-anodontia", "Pseudoanodontia", "Unerupted tooth" ; oboInOwl:id "HP:0000706" ; a owl:Class ; rdfs:comment "Usually a tooth erupts at a stage of half or two-thirds of root formation. There are established norms for the timing of eruption and tooth stages in both deciduous and permanent teeth. It may be difficult to discern Delayed eruption from failure of eruption: failure indicates it will never erupt, delayed indicates it may still erupt. Eruption failure may be caused by an isolated obstacle (supernumerary teeth), ankylosis of impacted teeth, or disturbances of biological eruption pathway. Partial or complete non-eruption of not initially ankylosed teeth due to a disturbed eruption mechanism result in a severe form of posterior open bite that usually worsens from anterior to posterior. Eruption failure is usually asymmetrical, affects more posterior teeth and both dentition may be involved. The diagnosis eruption failure requires clinical and radiographic examinations." ; rdfs:label "Eruption failure" ; rdfs:subClassOf obo:HP_0006292 . obo:HP_0000707 obo:IAO_0000115 "An abnormality of the nervous system." ; oboInOwl:hasAlternativeId "HP:0001333", "HP:0006987" ; oboInOwl:hasBroadSynonym "Brain and/or spinal cord issue" ; oboInOwl:hasDbXref "MSH:D009421", "SNOMEDCT_US:88425004", "UMLS:C0497552" ; oboInOwl:hasExactSynonym "Abnormality of the nervous system", "Neurologic abnormalities", "Neurological abnormality" ; oboInOwl:id "HP:0000707" ; a owl:Class ; rdfs:comment "The nervous system comprises the neuraxis (brain, spinal cord, and ventricles), the autonomic nervous system, the enteric nervous system, and the peripheral nervous system." ; rdfs:label "Abnormality of the nervous system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000708 obo:IAO_0000115 "An abnormality of mental functioning including various affective, behavioral, cognitive, and perceptual abnormalities." ; dcterms:contributor , , , , ; oboInOwl:hasAlternativeId "HP:0000715", "HP:0002368", "HP:0002456" ; oboInOwl:hasDbXref "MSH:D000066553", "MSH:D001526", "SNOMEDCT_US:25786006", "SNOMEDCT_US:277843001", "UMLS:C0004941", "UMLS:C0233514" ; oboInOwl:hasExactSynonym "Behavioral abnormality", "Behavioral changes", "Behavioral disorders", "Behavioral disturbances", "Behavioral problems", "Behavioral symptoms", "Behavioral/psychiatric abnormalities", "Behavioural abnormality", "Behavioural changes", "Behavioural disorders", "Behavioural disturbances", "Behavioural problems", "Behavioural symptoms", "Behavioural/Psychiatric abnormality", "Psychiatric disorders", "Psychiatric disturbances" ; oboInOwl:id "HP:0000708" ; a owl:Class ; rdfs:label "Atypical behavior" ; rdfs:subClassOf obo:HP_0011446 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000709 obo:IAO_0000115 "A condition characterized by changes of personality and thought patterns often accompanied by hallucinations and delusional beliefs." ; oboInOwl:hasDbXref "MSH:D011618", "SNOMEDCT_US:69322001", "UMLS:C0033975" ; oboInOwl:hasExactSynonym "Psychosis" ; oboInOwl:id "HP:0000709" ; a owl:Class ; rdfs:label "Psychosis" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000259 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000710 obo:IAO_0000115 "Hyperorality is a condition characterized by an excessive preoccupation with oral sensations and behaviors, such as chewing, sucking, biting, swallowing, and excessive mouthing of objects." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "UMLS:C1838320" ; oboInOwl:hasExactSynonym "Hyperoralia", "Hyperorality", "Mouthing" ; oboInOwl:id "HP:0000710" ; a owl:Class ; rdfs:label "Hyperorality" ; rdfs:subClassOf obo:HP_5200065 . obo:HP_0000711 obo:IAO_0000115 "A state of unease characterized by diffuse motor activity or motion, subject to limited control, nonproductive, or disorganized behavior." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:162221009", "UMLS:C3887611" ; oboInOwl:hasExactSynonym "Fidgetiness", "Restiveness" ; oboInOwl:id "HP:0000711" ; a owl:Class ; rdfs:label "Restlessness" ; rdfs:subClassOf obo:HP_5200045 . obo:HP_0000712 obo:IAO_0000115 "Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances." ; oboInOwl:hasAlternativeId "HP:0000720", "HP:0001575", "HP:0008766" ; oboInOwl:hasDbXref "SNOMEDCT_US:18963009", "UMLS:C0085633" ; oboInOwl:hasExactSynonym "Emotional instability", "Mood alterations", "Mood changes", "Mood lability", "Mood swings" ; oboInOwl:id "HP:0000712" ; a owl:Class ; rdfs:label "Emotional lability" ; rdfs:subClassOf obo:HP_0031466, obo:HP_0100851 . obo:HP_0000713 obo:IAO_0000115 "A state of exceeding restlessness and excessive motor activity associated with mental distress or a feeling of inner tension." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:24199005", "UMLS:C0085631" ; oboInOwl:id "HP:0000713" ; a owl:Class ; rdfs:label "Agitation" ; rdfs:subClassOf obo:HP_0000711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000716 obo:IAO_0000115 "Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior." ; oboInOwl:hasDbXref "MSH:D003866", "SNOMEDCT_US:21061000119107", "SNOMEDCT_US:35489007", "SNOMEDCT_US:78667006", "UMLS:C0011581" ; oboInOwl:hasExactSynonym "Depression", "Depressivity" ; oboInOwl:hasRelatedSynonym "Depressive disorder" ; oboInOwl:id "HP:0000716" ; a owl:Class ; rdfs:label "Depression" ; rdfs:subClassOf obo:HP_0031466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000515 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000717 obo:IAO_0000115 "Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. Autism begins in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual (DSM-IV)." ; oboInOwl:hasDbXref "MSH:D001321", "SNOMEDCT_US:408856003", "SNOMEDCT_US:408857007", "SNOMEDCT_US:43614003", "UMLS:C0004352" ; oboInOwl:hasExactSynonym "Autism" ; oboInOwl:id "HP:0000717" ; a owl:Class ; rdfs:comment "The term refers to the diagnosis of autism and is left for convenience. However, it is preferable to annotate the exact phenotypic abnormalities rather than merely the diagnostic category autism." ; rdfs:label "Autism" ; rdfs:subClassOf obo:HP_0000729 . obo:HP_0000718 obo:IAO_0000115 "Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." ; oboInOwl:hasDbXref "MSH:D000374", "SNOMEDCT_US:248004009", "SNOMEDCT_US:61372001", "UMLS:C0001807", "UMLS:C0424323", "UMLS:C1457883" ; oboInOwl:hasExactSynonym "Aggression", "Aggressive behavior", "Aggressive behaviour", "Aggressiveness" ; oboInOwl:hasRelatedSynonym "physical aggression" ; oboInOwl:id "HP:0000718" ; a owl:Class ; rdfs:label "Aggressive behavior" ; rdfs:subClassOf obo:HP_0006919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000719 oboInOwl:hasDbXref "SNOMEDCT_US:112082005", "UMLS:C0233522" ; oboInOwl:hasExactSynonym "Inappropriate behavior", "Inappropriate behaviour" ; oboInOwl:id "HP:0000719" ; a owl:Class ; rdfs:label "Inappropriate behavior" ; rdfs:subClassOf obo:HP_0031466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000720 obo:IAO_0100001 "HP:0000712" ; oboInOwl:id "HP:0000720" ; a owl:Class ; rdfs:label "obsolete Mood swings" ; owl:deprecated true . obo:HP_0000721 oboInOwl:hasDbXref "UMLS:C1837650" ; oboInOwl:hasExactSynonym "Lack of spontaneous play" ; oboInOwl:id "HP:0000721" ; a owl:Class ; rdfs:label "Lack of spontaneous play" ; rdfs:subClassOf obo:HP_5200104 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000722 obo:IAO_0000115 "Behavior that consists of repetitive acts that are characterized by the feeling that one 'has to' perform them while one is aware that these acts are not in line with one's overall goal" ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "MSH:D003192", "MSH:D009771", "SNOMEDCT_US:12479006", "SNOMEDCT_US:191736004", "UMLS:C0028768", "UMLS:C0600104" ; oboInOwl:hasExactSynonym "OCD", "Obsessive compulsive behavior", "Obsessive compulsive behaviour", "Obsessive compulsive disorder", "Obsessive-compulsive behavior", "Obsessive-compulsive behaviour", "Obsessive-compulsive disorder" ; oboInOwl:id "HP:0000722" ; a owl:Class ; rdfs:label "Compulsive behaviors" ; rdfs:subClassOf obo:HP_0031432 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000248 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000723 obo:IAO_0000115 "Behavior characterized by an abnormal limitation to few interests and activities." ; oboInOwl:hasDbXref "UMLS:C2675334", "UMLS:C4021799" ; oboInOwl:hasExactSynonym "Restricted behavior", "Restricted behaviour", "Restrictive behaviour" ; oboInOwl:hasRelatedSynonym "Restrictive behavior, interests, and activities" ; oboInOwl:id "HP:0000723" ; a owl:Class ; rdfs:label "Restrictive behavior" ; rdfs:subClassOf obo:HP_0000729 . obo:HP_0000725 oboInOwl:hasDbXref "UMLS:C0338614" ; oboInOwl:hasExactSynonym "Psychotic episodes" ; oboInOwl:id "HP:0000725" ; a owl:Class ; rdfs:label "Psychotic episodes" ; rdfs:subClassOf obo:HP_0000709 . obo:HP_0000726 obo:IAO_0000115 "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." ; oboInOwl:hasAlternativeId "HP:0002274", "HP:0007122", "HP:0007150", "HP:0007283" ; oboInOwl:hasDbXref "MSH:D003704", "SNOMEDCT_US:52448006", "UMLS:C0497327" ; oboInOwl:hasExactSynonym "Dementia", "Dementia, progressive", "Progressive dementia" ; oboInOwl:id "HP:0000726" ; a owl:Class ; rdfs:label "Dementia" ; rdfs:subClassOf obo:HP_0001268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000268 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000727 oboInOwl:hasDbXref "SNOMEDCT_US:278857002", "UMLS:C0338455" ; oboInOwl:id "HP:0000727" ; a owl:Class ; rdfs:label "Frontal lobe dementia" ; rdfs:subClassOf obo:HP_0000726 . obo:HP_0000728 oboInOwl:hasDbXref "UMLS:C1837649" ; oboInOwl:id "HP:0000728" ; a owl:Class ; rdfs:label "Impaired ability to form peer relationships" ; rdfs:subClassOf obo:HP_0000735 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000729 obo:IAO_0000115 "Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior." ; oboInOwl:hasDbXref "MSH:D000067877", "UMLS:C0856975", "UMLS:C1510586" ; oboInOwl:hasExactSynonym "ASD", "Autistic behaviour", "Pervasive developmental disorder" ; oboInOwl:hasRelatedSynonym "Autism spectrum disorder", "Autism spectrum disorders", "Autistic behaviors", "Autistic behaviours" ; oboInOwl:id "HP:0000729" ; a owl:Class ; rdfs:comment "This term can be used to refer to autism spectrum disorder as a phenotypic feature that can be a component of a disease. Autism spectrum disorder range from a severe form, called autistic disorder, to a milder form, Asperger syndrome." ; rdfs:label "Autistic behavior" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0000732 obo:IAO_0000115 "A need to strictly adhere to repetitive routines or patterns of behavior which are created by the environment. One becomes upset or distressed when their routines are disrupted or altered." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "UMLS:C1837653" ; oboInOwl:id "HP:0000732" ; a owl:Class ; rdfs:label "Inflexible adherence to routines" ; rdfs:subClassOf obo:HP_5200130 . obo:HP_0000733 obo:IAO_0000115 "Use of the same abnormal action in response to certain triggers or at random. They may be used as a way to regulate one's internal state but must otherwise have no apparent functional purpose." ; dcterms:contributor , , , , ; oboInOwl:hasAlternativeId "HP:0008758", "HP:0008759" ; oboInOwl:hasDbXref "MSH:D013239", "MSH:D019956", "SNOMEDCT_US:5507002", "SNOMEDCT_US:84328007", "UMLS:C0038271", "UMLS:C0038273" ; oboInOwl:hasExactSynonym "Motor stereotypy", "Repetitive behaviour Stereotypic behavior", "Repetitive behaviour Stereotypic behaviour", "Repetitive movements", "Stereotyped", "Stereotyped behavior", "Stereotyped behaviors", "Stereotyped behaviour", "Stereotyped behaviours", "Stereotypic behaviour", "Stereotypic behaviours", "Stereotypical motor behavior", "Stereotypical motor behaviors", "Stereotypical motor behaviour", "Stereotypical motor behaviours", "Stimming", "repetitive behavior", "repetitive behaviour" ; oboInOwl:id "HP:0000733" ; a owl:Class ; rdfs:label "Abnormal repetitive mannerisms" ; rdfs:subClassOf obo:HP_0031432 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000734 obo:IAO_0000115 "A lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:247977003", "UMLS:C0424296" ; oboInOwl:id "HP:0000734" ; a owl:Class ; rdfs:comment "Disinhibition affects motor, instinctual, emotional, cognitive, and perceptual aspects with signs and symptoms similar to the diagnostic criteria for mania. Hypersexuality, hyperphagia, and aggressive outbursts are indicative of disinhibited instinctual drives." ; rdfs:label "Disinhibition" ; rdfs:subClassOf obo:HP_5200045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000735 obo:IAO_0000115 "Difficulty in social interactions related to an impairment of characteristics such as eye contact, smiling, appropriate facial expressions, and body postures and characterized by difficulty in forming peer relationships and forming friendships." ; oboInOwl:hasDbXref "MSH:D000067404", "SNOMEDCT_US:88598008", "UMLS:C0150080" ; oboInOwl:hasExactSynonym "Impaired social interaction", "Impaired social interactions", "Poor social interactions" ; oboInOwl:id "HP:0000735" ; a owl:Class ; rdfs:label "Impaired social interactions" ; rdfs:subClassOf obo:HP_0000729, obo:HP_0012433 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000736 obo:IAO_0000115 "Reduced attention span characterized by distractibility and impulsivity." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:247762003", "UMLS:C0262630" ; oboInOwl:hasExactSynonym "Easily distracted", "Poor attention span", "Problem paying attention", "Short attention span" ; oboInOwl:id "HP:0000736" ; a owl:Class ; rdfs:label "Short attention span" ; rdfs:subClassOf obo:HP_5200044 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000499 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000455 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000737 obo:IAO_0000115 "A proneness to anger, i.e., a condition of being easily bothered or annoyed." ; oboInOwl:hasDbXref "UMLS:C2700617" ; oboInOwl:hasExactSynonym "Irritability", "Irritable" ; oboInOwl:id "HP:0000737" ; a owl:Class ; rdfs:label "Irritability" ; rdfs:subClassOf obo:HP_0100851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000738 obo:IAO_0000115 "Perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space." ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:7011001", "UMLS:C0018524", "UMLS:C0235153" ; oboInOwl:hasExactSynonym "Hallucination", "Hallucinations", "Sensory hallucination" ; oboInOwl:id "HP:0000738" ; a owl:Class ; rdfs:label "Hallucinations" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000608 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000739 obo:IAO_0000115 "Intense feelings of nervousness, tenseness, or panic, often in reaction to interpersonal stresses; worry about the negative effects of past unpleasant experiences and future negative possibilities; feeling fearful, apprehensive, or threatened by uncertainty; fears of falling apart or losing control." ; oboInOwl:hasDbXref "MSH:D001007", "SNOMEDCT_US:48694002", "UMLS:C0003467", "UMLS:C4020884" ; oboInOwl:hasExactSynonym "Anxiety", "Anxiousness", "Excessive, persistent worry and fear" ; oboInOwl:hasRelatedSynonym "Anxiety disease" ; oboInOwl:id "HP:0000739" ; a owl:Class ; rdfs:label "Anxiety" ; rdfs:subClassOf obo:HP_0100852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000740 obo:IAO_0000115 "Recurrent attacks of severe anxiety, whose occurence is not restricted to any particular situation or set of circumstances and is therefore unpredictable." ; oboInOwl:hasDbXref "UMLS:C1854339" ; oboInOwl:id "HP:0000740" ; a owl:Class ; rdfs:comment "An anxiety attack may manifest with one or more of the following symptoms: (i) breathing difficulty; (ii) palpitations; (iii) a feeling of unreality; (iv) pains or tightness in the chest; (v) trembling, dizziness or feeling unsteady; (vi) sweating; (vii) a feeling of faintness; (viii) a fear of dying; (ix) a feeling of losing control; (x) tingling in hands and feet (parasthesiae); (xi) choking or smothering feelings." ; rdfs:label "Episodic paroxysmal anxiety" ; rdfs:subClassOf obo:HP_0000739 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000739 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0002666 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000741 oboInOwl:hasDbXref "MSH:D057565", "SNOMEDCT_US:20602000", "UMLS:C0085632" ; oboInOwl:hasExactSynonym "Lack of feeling, emotion, interest" ; oboInOwl:id "HP:0000741" ; a owl:Class ; rdfs:label "Apathy" ; rdfs:subClassOf obo:HP_0000745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000602 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000742 oboInOwl:hasDbXref "MSH:D012652", "SNOMEDCT_US:130968006", "UMLS:C0036601" ; oboInOwl:hasExactSynonym "Deliberate self-harm", "Self mutilation", "Self-mutilation" ; oboInOwl:id "HP:0000742" ; a owl:Class ; rdfs:label "Self-mutilation" ; rdfs:subClassOf obo:HP_0100716 . obo:HP_0000743 obo:IAO_0000115 "Primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes." ; oboInOwl:hasAlternativeId "HP:0006911" ; oboInOwl:hasDbXref "UMLS:C1833297" ; oboInOwl:hasExactSynonym "Frontal release reflexes" ; oboInOwl:id "HP:0000743" ; a owl:Class ; rdfs:label "Frontal release signs" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0000744 obo:IAO_0000115 "The feeling of frustration can be defined as an emotional reaction that occurs if a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration characterized by crying or temper tantrums (in children) or aggressive or other undesirable behaviors." ; oboInOwl:hasDbXref "UMLS:C0548883" ; oboInOwl:hasExactSynonym "Intolerance to frustration" ; oboInOwl:id "HP:0000744" ; a owl:Class ; rdfs:label "Low frustration tolerance" ; rdfs:subClassOf obo:HP_0100851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000745 obo:IAO_0000115 "A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action." ; oboInOwl:hasDbXref "SNOMEDCT_US:277521002", "UMLS:C0456814" ; oboInOwl:hasExactSynonym "Diminished motivation", "Lack of initiative", "Lack of motivation", "Lacking in initiative", "Lacks initiative" ; oboInOwl:id "HP:0000745" ; a owl:Class ; rdfs:label "Diminished motivation" ; rdfs:subClassOf obo:HP_0100851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000746 obo:IAO_0000115 "A false belief that is held despite evidence to the contrary." ; oboInOwl:hasDbXref "MSH:D003702", "SNOMEDCT_US:2073000", "UMLS:C0011253" ; oboInOwl:hasExactSynonym "Delusions" ; oboInOwl:id "HP:0000746" ; a owl:Class ; rdfs:label "Delusions" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000748 oboInOwl:hasDbXref "SNOMEDCT_US:247985007", "UMLS:C0424304" ; oboInOwl:hasExactSynonym "Inappropriate laughter" ; oboInOwl:id "HP:0000748" ; a owl:Class ; rdfs:label "Inappropriate laughter" ; rdfs:subClassOf obo:HP_5200123 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000617 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000749 oboInOwl:hasDbXref "UMLS:C1839749" ; oboInOwl:hasExactSynonym "Paroxysmal laughter" ; oboInOwl:id "HP:0000749" ; a owl:Class ; rdfs:label "Paroxysmal bursts of laughter" ; rdfs:subClassOf obo:HP_0000748 . obo:HP_0000750 obo:IAO_0000115 "A degree of language development that is significantly below the norm for a child of a specified age." ; oboInOwl:hasAlternativeId "HP:0002116", "HP:0002117", "HP:0002336", "HP:0002399", "HP:0002498", "HP:0006936", "HP:0007004", "HP:0007127", "HP:0007170", "HP:0007172" ; oboInOwl:hasDbXref "MSH:D007805", "SNOMEDCT_US:162294008", "SNOMEDCT_US:229721007", "SNOMEDCT_US:29164008", "SNOMEDCT_US:62415009", "UMLS:C0023012", "UMLS:C0233715", "UMLS:C0241210", "UMLS:C0454644" ; oboInOwl:hasExactSynonym "Deficiency of speech development", "Delayed language development", "Delayed speech", "Delayed speech acquisition", "Delayed speech and language development", "Delayed speech development", "Impaired speech and language development", "Impaired speech development", "Language delay", "Language delayed", "Language development deficit", "Late-onset speech development", "Poor language development", "Speech and language delay", "Speech and language difficulties", "Speech delay" ; oboInOwl:hasRelatedSynonym "Poor speech acquisition", "Poor speech development", "Speech difficulties" ; oboInOwl:id "HP:0000750" ; a owl:Class ; rdfs:comment "Language delay can be characterized by a failure to meet the developmental milestones for language development, an inability to follow directions, or slow or incomprehensible speech after the age of three years, as well as with severe problems with syntax or articulation." ; rdfs:label "Delayed speech and language development" ; rdfs:subClassOf obo:HP_0002167, obo:HP_0002463, obo:HP_0012758 . obo:HP_0000751 obo:IAO_0000115 "An abnormal shift in patterns of thinking, acting, or feeling." ; oboInOwl:hasDbXref "SNOMEDCT_US:102943000", "SNOMEDCT_US:192073007", "UMLS:C0240735" ; oboInOwl:hasExactSynonym "Personality change", "Personality changes" ; oboInOwl:id "HP:0000751" ; a owl:Class ; rdfs:comment "This term refers to changes in personality that are perceived as being abnormal. It does not refer to the usual gradual personality changes that tend to accompany aging and certain life situations." ; rdfs:label "Personality changes" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000265 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000752 obo:IAO_0000115 "Hyperactivity is a state of constantly being unusually or abnormally active, including in situations in which it is not appropriate." ; dcterms:contributor , , , , ; oboInOwl:hasAlternativeId "HP:0008764" ; oboInOwl:hasDbXref "MSH:D006948", "SNOMEDCT_US:44548000", "UMLS:C0424295" ; oboInOwl:hasExactSynonym "Hyperactive behavior", "Hyperactive behaviour", "More active than typical", "hyperkinetic disorder" ; oboInOwl:id "HP:0000752" ; a owl:Class ; rdfs:label "Hyperactivity" ; rdfs:subClassOf obo:HP_5200045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000753 oboInOwl:hasDbXref "UMLS:C4025832" ; oboInOwl:id "HP:0000753" ; a owl:Class ; rdfs:label "Autism with high cognitive abilities" ; rdfs:subClassOf obo:HP_0000729 . obo:HP_0000756 obo:IAO_0000115 "A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather." ; oboInOwl:hasDbXref "MSH:D000379", "SNOMEDCT_US:247830007", "SNOMEDCT_US:70691001", "UMLS:C0001818" ; oboInOwl:hasExactSynonym "Fear of open spaces" ; oboInOwl:id "HP:0000756" ; a owl:Class ; rdfs:label "Agoraphobia" ; rdfs:subClassOf obo:HP_0100852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000757 oboInOwl:hasDbXref "SNOMEDCT_US:24340004", "UMLS:C0233824" ; oboInOwl:hasExactSynonym "Lack of insight" ; oboInOwl:id "HP:0000757" ; a owl:Class ; rdfs:label "Lack of insight" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0000758 obo:IAO_0000115 "Abnormalities in eye contact, communicative facial expressions, gesture use, or use of other's body to communicate. These convey a shared meaning within a culture that replace or supplement verbal communication." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "UMLS:C4021798" ; oboInOwl:hasExactSynonym "Impaired use of nonverbal behaviors", "Impaired use of nonverbal behaviours" ; oboInOwl:id "HP:0000758" ; a owl:Class ; rdfs:label "Abnormal nonverbal communicative behavior" ; rdfs:subClassOf obo:HP_0034434 . obo:HP_0000759 obo:IAO_0000115 "A structural abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system)." ; oboInOwl:hasAlternativeId "HP:0003483" ; oboInOwl:hasDbXref "MSH:D010523", "SNOMEDCT_US:302226006", "SNOMEDCT_US:42658009", "UMLS:C0031117", "UMLS:C4025831" ; oboInOwl:hasExactSynonym "Abnormal peripheral nervous system structure" ; oboInOwl:hasRelatedSynonym "Peripheral nervous system disease" ; oboInOwl:id "HP:0000759" ; a owl:Class ; rdfs:comment "The peripheral nervous system is divided into autonomic and somatic components, which both include afferent (sensory) and efferent (motor) nerves." ; rdfs:label "Abnormal peripheral nervous system morphology" ; rdfs:subClassOf obo:HP_0012639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000762 obo:IAO_0000115 "A reduction in the speed at which electrical signals propagate along the axon of a neuron." ; oboInOwl:hasAlternativeId "HP:0000761", "HP:0007118", "HP:0007218", "HP:0007231" ; oboInOwl:hasDbXref "UMLS:C1857640" ; oboInOwl:hasExactSynonym "Decreased NCV", "Decreased nerve conduction velocities", "Delayed nerve conduction velocity", "Reduced nerve conduction velocities", "Slow nerve conduction velocity", "Slowed nerve conduction velocities" ; oboInOwl:id "HP:0000762" ; a owl:Class ; rdfs:comment "Nerve conduction velocity is usually measured with surface electrodes placed on the skin over nerves at various locations. Following stimulation at one electrode, the speed at which the signal is propagated to other electrodes is recorded. Abnormal values may suggest demyelination, a conduction block, or axonopathy." ; rdfs:label "Decreased nerve conduction velocity" ; rdfs:subClassOf obo:HP_0040129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000111 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019226 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000763 obo:IAO_0000115 "Peripheral neuropathy affecting the sensory nerves." ; oboInOwl:hasAlternativeId "HP:0003410", "HP:0006815", "HP:0007043", "HP:0007142" ; oboInOwl:hasDbXref "SNOMEDCT_US:95662005", "UMLS:C0151313" ; oboInOwl:hasExactSynonym "Damage to nerves that sense feeling", "Peripheral sensory neuropathy" ; oboInOwl:id "HP:0000763" ; a owl:Class ; rdfs:label "Sensory neuropathy" ; rdfs:subClassOf obo:HP_0009830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001027 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000764 obo:IAO_0000115 "Progressive deterioration of peripheral axons." ; oboInOwl:hasAlternativeId "HP:0006787", "HP:0006876", "HP:0007304" ; oboInOwl:hasDbXref "UMLS:C4025830" ; oboInOwl:id "HP:0000764" ; a owl:Class ; rdfs:comment "This finding is typically demonstrated by nerve biopsy." ; rdfs:label "Peripheral axonal degeneration" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0000765 obo:IAO_0000115 "Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs)." ; oboInOwl:hasAlternativeId "HP:0100655" ; oboInOwl:hasDbXref "UMLS:C4021797" ; oboInOwl:hasExactSynonym "Abnormality of the chest", "Abnormality of the thorax", "Structural abnormality of the chest wall" ; oboInOwl:id "HP:0000765" ; a owl:Class ; rdfs:label "Abnormal thorax morphology" ; rdfs:subClassOf obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000766 obo:IAO_0000115 "An anomaly of the sternum, also known as the breastbone." ; oboInOwl:hasAlternativeId "HP:0000780", "HP:0006586", "HP:0006594", "HP:0006605", "HP:0006630", "HP:0006708" ; oboInOwl:hasDbXref "UMLS:C1860493" ; oboInOwl:hasExactSynonym "Abnormality of the sternum", "Pectus carinatum or pectus excavatum", "Pectus deformities", "Pectus deformity", "Pectus excavatum or carinatum", "Pectus excavatum or pectus carinatum", "Pectus excavatum/carinatum", "Sternal anomalies" ; oboInOwl:id "HP:0000766" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal sternum morphology" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000767 obo:IAO_0000115 "A defect of the chest wall characterized by a depression of the sternum, giving the chest (\"pectus\") a caved-in (\"excavatum\") appearance." ; oboInOwl:hasAlternativeId "HP:0006613", "HP:0006617" ; oboInOwl:hasDbXref "SNOMEDCT_US:391987005", "UMLS:C2051831" ; oboInOwl:hasExactSynonym "Funnel chest" ; oboInOwl:id "HP:0000767" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pectus excavatum" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001857 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000768 obo:IAO_0000115 "A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum." ; oboInOwl:hasAlternativeId "HP:0006639" ; oboInOwl:hasDbXref "MSH:D066166", "SNOMEDCT_US:205101001", "UMLS:C0158731" ; oboInOwl:hasExactSynonym "Pigeon chest" ; oboInOwl:id "HP:0000768" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pectus carinatum" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000769 obo:IAO_0000115 "An abnormality of the breast." ; oboInOwl:hasDbXref "UMLS:C4025829" ; oboInOwl:hasExactSynonym "Abnormality of the breast" ; oboInOwl:id "HP:0000769" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the breast" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000771 obo:IAO_0000115 "Abnormal development of large mammary glands in males resulting in breast enlargement." ; oboInOwl:hasAlternativeId "HP:0000770" ; oboInOwl:hasDbXref "MSH:D006177", "SNOMEDCT_US:4754008", "UMLS:C0018418" ; oboInOwl:hasExactSynonym "Enlarged male breast", "Gynaecomastia" ; oboInOwl:id "HP:0000771" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gynecomastia" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005200 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016410 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000772 obo:IAO_0000115 "An anomaly of the rib." ; oboInOwl:hasAlternativeId "HP:0006618" ; oboInOwl:hasDbXref "UMLS:C1842083" ; oboInOwl:hasExactSynonym "Abnormality of the ribs", "Rib abnormalities", "Rib anomalies" ; oboInOwl:id "HP:0000772" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal rib morphology" ; rdfs:subClassOf obo:HP_0001547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000773 obo:IAO_0000115 "Reduced rib length." ; oboInOwl:hasAlternativeId "HP:0000899", "HP:0000908", "HP:0009750" ; oboInOwl:hasDbXref "SNOMEDCT_US:249696007", "UMLS:C0426817" ; oboInOwl:hasExactSynonym "Hypoplastic ribs", "Rib hypoplasia", "Short ribs" ; oboInOwl:id "HP:0000773" ; a owl:Class ; rdfs:label "Short ribs" ; rdfs:subClassOf obo:HP_0006712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000774 obo:IAO_0000115 "Reduced width of the chest from side to side, associated with a reduced distance from the sternal notch to the tip of the shoulder." ; oboInOwl:hasAlternativeId "HP:0000909", "HP:0005252", "HP:0006588" ; oboInOwl:hasDbXref "SNOMEDCT_US:249671009", "UMLS:C0426790" ; oboInOwl:hasExactSynonym "Low chest circumference", "Narrow chest", "Narrow shoulders", "Narrow thorax", "Reduced anterior-posterior chest diameter" ; oboInOwl:id "HP:0000774" ; a owl:Class ; rdfs:label "Narrow chest" ; rdfs:subClassOf obo:HP_0005257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016416 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000775 obo:IAO_0000115 "Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity." ; oboInOwl:hasAlternativeId "HP:0005204" ; oboInOwl:hasDbXref "UMLS:C1848873" ; oboInOwl:hasExactSynonym "Abnormality of the diaphragm", "Diaphragm issues", "Diaphragmatic defect" ; oboInOwl:id "HP:0000775" ; a owl:Class ; rdfs:label "Abnormality of the diaphragm" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000776 obo:IAO_0000115 "The presence of a hernia of the diaphragm present at birth." ; oboInOwl:hasAlternativeId "HP:0006604" ; oboInOwl:hasDbXref "MSH:D065630", "SNOMEDCT_US:17190001", "UMLS:C0235833" ; oboInOwl:hasExactSynonym "Diaphragmatic hernia" ; oboInOwl:id "HP:0000776" ; a owl:Class ; rdfs:comment "Diaphragmatic hernia is the result of a developmental defect causing an abnormal opening in the diaphragm, through which abdominal organs (stomach, spleen, liver, and intestines) can protrude into the thoracic cavity. This usually causes respiratory distress in the newborn period." ; rdfs:label "Congenital diaphragmatic hernia" ; rdfs:subClassOf obo:HP_0000775, obo:HP_0100790 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002163 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0017672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000777 obo:IAO_0000115 "Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation." ; oboInOwl:hasDbXref "SNOMEDCT_US:93297002", "UMLS:C0262650", "UMLS:C0685891" ; oboInOwl:hasExactSynonym "Abnormality of the thymus" ; oboInOwl:id "HP:0000777" ; a owl:Class ; rdfs:label "Abnormal thymus morphology" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000778 obo:IAO_0000115 "Underdevelopment of the thymus." ; oboInOwl:hasDbXref "SNOMEDCT_US:93297002", "UMLS:C0685891", "UMLS:C4228227" ; oboInOwl:hasExactSynonym "Small thymus", "Thymic hypoplasia", "Thymus hypoplasia" ; oboInOwl:id "HP:0000778" ; a owl:Class ; rdfs:label "Hypoplasia of the thymus" ; rdfs:subClassOf obo:HP_0010515 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000782 obo:IAO_0000115 "Any abnormality of the scapula, also known as the shoulder blade." ; oboInOwl:hasDbXref "UMLS:C4025828" ; oboInOwl:hasExactSynonym "Abnormality of the shoulder blade" ; oboInOwl:id "HP:0000782" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal scapula morphology" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006849 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000786 oboInOwl:hasDbXref "SNOMEDCT_US:8913004", "UMLS:C0232939" ; oboInOwl:id "HP:0000786" ; a owl:Class ; rdfs:label "Primary amenorrhea" ; rdfs:subClassOf obo:HP_0000141 . obo:HP_0000787 obo:IAO_0000115 "The presence of calculi (stones) in the kidneys." ; oboInOwl:hasAlternativeId "HP:0000102" ; oboInOwl:hasDbXref "MSH:D053040", "UMLS:C0392525" ; oboInOwl:hasExactSynonym "Kidney stones", "Renal calculi", "Renal stones" ; oboInOwl:id "HP:0000787" ; a owl:Class ; rdfs:comment "Urinary stone disease is caused by supersaturation of the urine by stone forming substances including calcium, oxalate, and uric acid. Crystals or foreign bodies can act as a nidus for further stone formation. The resulting kidney stones (calculi) lead to symptoms if they become impacted in the ureter." ; rdfs:label "Nephrolithiasis" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0000789 oboInOwl:hasDbXref "MSH:D007246", "SNOMEDCT_US:15296000", "SNOMEDCT_US:8619003", "UMLS:C0021359" ; oboInOwl:hasExactSynonym "Infertility" ; oboInOwl:id "HP:0000789" ; a owl:Class ; rdfs:label "Infertility" ; rdfs:subClassOf obo:HP_0000144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000956 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000790 obo:IAO_0000115 "The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine)." ; oboInOwl:hasBroadSynonym "High urine occult blood" ; oboInOwl:hasDbXref "MSH:D006417", "SNOMEDCT_US:34436003", "SNOMEDCT_US:53298000", "UMLS:C0018965" ; oboInOwl:hasExactSynonym "Blood in urine" ; oboInOwl:id "HP:0000790" ; a owl:Class ; rdfs:label "Hematuria" ; rdfs:subClassOf obo:HP_0012211, obo:HP_0012614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000791 obo:IAO_0000115 "The presence of uric acid-containing calculi (stones) in the kidneys." ; oboInOwl:hasDbXref "SNOMEDCT_US:267441009", "UMLS:C0403719" ; oboInOwl:hasExactSynonym "Uric acid stones", "Uric acid urolithiasis" ; oboInOwl:id "HP:0000791" ; a owl:Class ; rdfs:label "Uric acid nephrolithiasis" ; rdfs:subClassOf obo:HP_0000787 . obo:HP_0000793 obo:IAO_0000115 "A type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity" ; oboInOwl:hasDbXref "MSH:D015432", "SNOMEDCT_US:80321008", "UMLS:C0017662" ; oboInOwl:hasExactSynonym "MPGN", "Mesangiocapillary glomerulonephritis" ; oboInOwl:id "HP:0000793" ; a owl:Class ; rdfs:label "Membranoproliferative glomerulonephritis" ; rdfs:subClassOf obo:HP_0000099 . obo:HP_0000794 obo:IAO_0000115 "The presence of immunoglobulin A deposits in the glomerulus." ; oboInOwl:hasDbXref "MSH:D005922", "SNOMEDCT_US:236407003", "SNOMEDCT_US:68779003", "UMLS:C0017661", "UMLS:C4025827" ; oboInOwl:hasRelatedSynonym "IgA nephropathy" ; oboInOwl:id "HP:0000794" ; a owl:Class ; rdfs:label "IgA deposition in the glomerulus" ; rdfs:subClassOf obo:HP_0030949 . obo:HP_0000795 obo:IAO_0000115 "An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body." ; oboInOwl:hasDbXref "UMLS:C4025826" ; oboInOwl:hasExactSynonym "Urethra issue" ; oboInOwl:id "HP:0000795" ; a owl:Class ; rdfs:label "Abnormality of the urethra" ; rdfs:subClassOf obo:HP_0010936 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000057 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000796 obo:IAO_0000115 "Obstruction of the flow of urine through the urethra." ; oboInOwl:hasDbXref "MSH:D014524", "SNOMEDCT_US:95588004", "UMLS:C0041972" ; oboInOwl:id "HP:0000796" ; a owl:Class ; rdfs:label "Urethral obstruction" ; rdfs:subClassOf obo:HP_0000795 . obo:HP_0000798 obo:IAO_0000115 "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen." ; oboInOwl:hasDbXref "MSH:D009845", "UMLS:C0028960" ; oboInOwl:hasExactSynonym "Low sperm count", "Oligospermia" ; oboInOwl:id "HP:0000798" ; a owl:Class ; rdfs:label "Oligozoospermia" ; rdfs:subClassOf obo:HP_0008669 . obo:HP_0000799 obo:IAO_0000115 "Abnormal fat accumulation in the kidneys." ; oboInOwl:hasDbXref "UMLS:C4021796" ; oboInOwl:hasExactSynonym "Fatty kidney" ; oboInOwl:id "HP:0000799" ; a owl:Class ; rdfs:label "Renal steatosis" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000800 oboInOwl:hasAlternativeId "HP:0008737" ; oboInOwl:hasDbXref "UMLS:C1834931" ; oboInOwl:hasExactSynonym "Bilateral cystic dysplasia", "Renal cystic dysplasia", "Renal dysplasia, cystic" ; oboInOwl:id "HP:0000800" ; a owl:Class ; rdfs:label "Cystic renal dysplasia" ; rdfs:subClassOf obo:HP_0000107 . obo:HP_0000802 obo:IAO_0000115 "Inability to develop or maintain an erection of the penis." ; oboInOwl:hasDbXref "MSH:D007172", "SNOMEDCT_US:397803000", "UMLS:C0242350" ; oboInOwl:hasExactSynonym "Difficulty getting a full erection", "Difficulty getting an erection" ; oboInOwl:id "HP:0000802" ; a owl:Class ; rdfs:label "Impotence" ; rdfs:subClassOf obo:HP_0012874, obo:HP_0100639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0043084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000803 obo:IAO_0000115 "Cysts of the cortex of the kidney." ; oboInOwl:hasDbXref "UMLS:C1969144" ; oboInOwl:hasExactSynonym "Cortical cysts" ; oboInOwl:id "HP:0000803" ; a owl:Class ; rdfs:label "Renal cortical cysts" ; rdfs:subClassOf obo:HP_0000107, obo:HP_0011035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000804 obo:IAO_0000115 "The presence of xanthine-containing calculi (stones) in the kidneys." ; oboInOwl:hasDbXref "UMLS:C1848431" ; oboInOwl:hasExactSynonym "Urinary xanthine stones", "Xanthine stones" ; oboInOwl:id "HP:0000804" ; a owl:Class ; rdfs:label "Xanthine nephrolithiasis" ; rdfs:subClassOf obo:HP_0000787 . obo:HP_0000805 obo:IAO_0000115 "Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible." ; oboInOwl:hasDbXref "MSH:D004775", "SNOMEDCT_US:8009008", "UMLS:C0014394" ; oboInOwl:id "HP:0000805" ; a owl:Class ; rdfs:label "Enuresis" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0000807 oboInOwl:hasDbXref "SNOMEDCT_US:204891000", "SNOMEDCT_US:429631000124104", "UMLS:C0452168" ; oboInOwl:id "HP:0000807" ; a owl:Class ; rdfs:label "Glandular hypospadias" ; rdfs:subClassOf obo:HP_0000047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0016409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000808 obo:IAO_0000115 "A severe form of hypospadias in which the urethral opening is located at the junction of the penis and scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:204889008", "UMLS:C0452147" ; oboInOwl:id "HP:0000808" ; a owl:Class ; rdfs:label "Penoscrotal hypospadias" ; rdfs:subClassOf obo:HP_0000047 . obo:HP_0000809 obo:IAO_0000115 "Congenital absence of the normal opening of a structure of the urinary tract." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T04:07:00Z" ; oboInOwl:hasDbXref "UMLS:C1389003" ; oboInOwl:id "HP:0000809" ; a owl:Class ; rdfs:label "Urinary tract atresia" ; rdfs:subClassOf obo:HP_0000079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000811 oboInOwl:hasDbXref "UMLS:C4025825" ; oboInOwl:hasExactSynonym "Abnormal external genitalia" ; oboInOwl:id "HP:0000811" ; a owl:Class ; rdfs:label "Abnormal external genitalia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004176 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000812 obo:IAO_0000115 "An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male)." ; oboInOwl:hasDbXref "UMLS:C4025824" ; oboInOwl:hasExactSynonym "Abnormal internal genitalia" ; oboInOwl:id "HP:0000812" ; a owl:Class ; rdfs:label "Abnormal internal genitalia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004175 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000813 obo:IAO_0000115 "The presence of a bicornuate uterus." ; oboInOwl:hasAlternativeId "HP:0008735" ; oboInOwl:hasDbXref "SNOMEDCT_US:31401003", "UMLS:C0266387" ; oboInOwl:hasExactSynonym "Heart shaped uterus", "Heart-shaped uterus", "Uterus bicornis" ; oboInOwl:id "HP:0000813" ; a owl:Class ; rdfs:comment "Uterus with two horn-shaped branches." ; rdfs:label "Bicornuate uterus" ; rdfs:subClassOf obo:HP_0031105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002161 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000815 obo:IAO_0000115 "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay." ; oboInOwl:hasAlternativeId "HP:0008679" ; oboInOwl:hasDbXref "MSH:D007006", "SNOMEDCT_US:370999003", "UMLS:C0948896" ; oboInOwl:hasExactSynonym "Hypergonadotrophic hypogonadism", "Primary hypogonadism" ; oboInOwl:id "HP:0000815" ; a owl:Class ; rdfs:label "Hypergonadotropic hypogonadism" ; rdfs:subClassOf obo:HP_0000135 . obo:HP_0000816 obo:IAO_0000115 "An abnormality of the tricarboxylic acid cycle." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T12:58:00Z" ; oboInOwl:hasDbXref "UMLS:C4021795" ; oboInOwl:hasExactSynonym "Abnormality of citric acid cycle", "Abnormality of the tricarboxylic cycle" ; oboInOwl:id "HP:0000816" ; a owl:Class ; rdfs:label "Abnormality of Krebs cycle metabolism" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0072350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000817 obo:IAO_0000115 "A reduced frequency or duration of eye contact." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:412786000", "UMLS:C1445953" ; oboInOwl:hasExactSynonym "Poor eye contact" ; oboInOwl:id "HP:0000817" ; a owl:Class ; rdfs:comment "Eye contact, defined as the meeting of the gaze between two people during a conversation, is an important form of nonverbal communication." ; rdfs:label "Reduced eye contact" ; rdfs:subClassOf obo:HP_0034435 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000818 obo:IAO_0000115 "An abnormality of the endocrine system." ; oboInOwl:hasDbXref "MSH:D004700", "SNOMEDCT_US:362969004", "UMLS:C0014130", "UMLS:C4025823" ; oboInOwl:hasRelatedSynonym "Endocrine system disease" ; oboInOwl:id "HP:0000818" ; a owl:Class ; rdfs:comment "The endocrine system is composed of glands that secrete hormones directly into the bloodstream and includes the following glands: thyroid, parathyroids, adrenals, pancreas, gonads (testicles and ovaries), and pituitary. Many other organs, such as the kidney, liver, and heart, have secondary endocrine functions." ; rdfs:label "Abnormality of the endocrine system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000949 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000819 obo:IAO_0000115 "A group of abnormalities characterized by hyperglycemia and glucose intolerance." ; oboInOwl:hasAlternativeId "HP:0004908", "HP:0008217", "HP:0008234", "HP:0008260" ; oboInOwl:hasDbXref "MSH:D003920", "SNOMEDCT_US:73211009", "UMLS:C0011849" ; oboInOwl:id "HP:0000819" ; a owl:Class ; rdfs:label "Diabetes mellitus" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0001952 . obo:HP_0000820 obo:IAO_0000115 "An abnormality of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D013959", "SNOMEDCT_US:14304000", "UMLS:C0040128" ; oboInOwl:hasExactSynonym "Abnormality of the thyroid gland", "Thyroid abnormality" ; oboInOwl:hasRelatedSynonym "Thyroid disease" ; oboInOwl:id "HP:0000820" ; a owl:Class ; rdfs:label "Abnormality of the thyroid gland" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000821 obo:IAO_0000115 "Deficiency of thyroid hormone." ; oboInOwl:hasAlternativeId "HP:0003222", "HP:0008203" ; oboInOwl:hasDbXref "MSH:D007037", "SNOMEDCT_US:40930008", "UMLS:C0020676" ; oboInOwl:hasExactSynonym "Low T4", "Underactive thyroid" ; oboInOwl:id "HP:0000821" ; a owl:Class ; rdfs:label "Hypothyroidism" ; rdfs:subClassOf obo:HP_0002926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000822 obo:IAO_0000115 "The presence of chronic increased pressure in the systemic arterial system." ; oboInOwl:hasAlternativeId "HP:0004949", "HP:0005126" ; oboInOwl:hasDbXref "MSH:D006973", "SNOMEDCT_US:24184005", "SNOMEDCT_US:38341003", "UMLS:C0020538", "UMLS:C0497247" ; oboInOwl:hasExactSynonym "Arterial hypertension", "Systemic hypertension" ; oboInOwl:hasRelatedSynonym "High blood pressure" ; oboInOwl:id "HP:0000822" ; a owl:Class ; rdfs:comment "Hypertension is sustained elevation of resting systolic BP (140 mm Hg or higher), diastolic BP (90 mm Hg or higher), or both." ; rdfs:label "Hypertension" ; rdfs:subClassOf obo:HP_0032263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001576 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0000823 obo:IAO_0000115 "Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty." ; oboInOwl:hasAlternativeId "HP:0008859", "HP:0010466", "HP:0010467" ; oboInOwl:hasDbXref "MSH:D011628", "SNOMEDCT_US:123526007", "SNOMEDCT_US:400003000", "UMLS:C0034012" ; oboInOwl:hasExactSynonym "Delayed pubertal development", "Delayed pubertal growth", "Delayed puberty", "Pubertal delay" ; oboInOwl:id "HP:0000823" ; a owl:Class ; rdfs:comment "The age at which delayed puberty may be diagnosed in a person without signs of secondary sexual development is 13 years in a girl or 14 years in a boy." ; rdfs:label "Delayed puberty" ; rdfs:subClassOf obo:HP_0001510, obo:HP_0008373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0045136 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000824 obo:IAO_0000115 "Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests." ; oboInOwl:hasAlternativeId "HP:0000861", "HP:0008195", "HP:0008206" ; oboInOwl:hasDbXref "SNOMEDCT_US:2109003", "UMLS:C3714796" ; oboInOwl:hasExactSynonym "Growth hormone deficiency", "Somatotropin deficiency" ; oboInOwl:id "HP:0000824" ; a owl:Class ; rdfs:comment "GH stimulation tests are performed with various stimuli, such as insulin, L-dopa, arginine, and growth hormone releasing hormone (GHRH). The test using insulin as a stimulus is classically recommended, but this test has potential risks such as hypoglycemia. The effects of growth hormone are mediated almost exclusively by insulin-like growth factor 1(IGF-1), which is produced primarily in the liver. Growth hormone deficiency refers to inadequate levels of GH (and therefore IGF-1), resulting in growth retardation in children and metabolic disturbances in adults." ; rdfs:label "Decreased response to growth hormone stimulation test" ; rdfs:subClassOf obo:HP_0000830, obo:HP_0031073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000825 obo:IAO_0000115 "An increased concentration of insulin combined with a decreased concentration of glucose in the blood." ; oboInOwl:hasDbXref "UMLS:C1864903" ; oboInOwl:hasExactSynonym "Hyperinsulinaemic hypoglycaemia", "Hyperinsulinemia hypoglycemia" ; oboInOwl:id "HP:0000825" ; a owl:Class ; rdfs:comment "Hyperinsulinemic hypoglycemia describes a situation in which the level of insulin is inappropriate for the low level of blood sugar." ; rdfs:label "Hyperinsulinemic hypoglycemia" ; rdfs:subClassOf obo:HP_0000842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000842 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001943 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000826 obo:IAO_0000115 "The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys." ; oboInOwl:hasDbXref "MSH:D011629", "SNOMEDCT_US:123527003", "SNOMEDCT_US:400179000", "UMLS:C0034013" ; oboInOwl:hasExactSynonym "Early onset of puberty", "Early puberty" ; oboInOwl:id "HP:0000826" ; a owl:Class ; rdfs:label "Precocious puberty" ; rdfs:subClassOf obo:HP_0100000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0045136 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000828 obo:IAO_0000115 "An abnormality of the parathyroid gland." ; oboInOwl:hasDbXref "MSH:D010279", "SNOMEDCT_US:73132005", "UMLS:C0030517", "UMLS:C4025822" ; oboInOwl:hasRelatedSynonym "Parathyroid disease" ; oboInOwl:id "HP:0000828" ; a owl:Class ; rdfs:comment "There are four parathyroid glands, which are small endocrine glands located in the neck behind the thyroid gland that produce parathyroid hormone." ; rdfs:label "Abnormality of the parathyroid gland" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000829 obo:IAO_0000115 "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia." ; oboInOwl:hasAlternativeId "HP:0000856", "HP:0008292" ; oboInOwl:hasDbXref "MSH:D007011", "SNOMEDCT_US:36976004", "UMLS:C0020626" ; oboInOwl:hasExactSynonym "Decreased parathyroid hormone secretion", "Low parathyroid hormone" ; oboInOwl:id "HP:0000829" ; a owl:Class ; rdfs:label "Hypoparathyroidism" ; rdfs:subClassOf obo:HP_0011767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000830 obo:IAO_0000115 "A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone." ; oboInOwl:hasDbXref "UMLS:C4025821" ; oboInOwl:id "HP:0000830" ; a owl:Class ; rdfs:label "Anterior hypopituitarism" ; rdfs:subClassOf obo:HP_0040075 . obo:HP_0000831 obo:IAO_0000115 "A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as well as in fasting and postprandial serum insulin levels." ; oboInOwl:hasDbXref "UMLS:C0854110" ; oboInOwl:hasExactSynonym "Insulin resistant diabetes", "Insulin resistant diabetes mellitus", "Insulin-resistant diabetes" ; oboInOwl:id "HP:0000831" ; a owl:Class ; rdfs:label "Insulin-resistant diabetes mellitus" ; rdfs:subClassOf obo:HP_0000819, obo:HP_0000855 . obo:HP_0000832 obo:IAO_0000115 "A type of hypothyroidism that results from a defect in the thyroid gland." ; oboInOwl:hasDbXref "SNOMEDCT_US:111566002", "UMLS:C0700502" ; oboInOwl:id "HP:0000832" ; a owl:Class ; rdfs:label "Primary hypothyroidism" ; rdfs:subClassOf obo:HP_0000821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000821 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000833 obo:IAO_0100001 "HP:0001952" ; oboInOwl:id "HP:0000833" ; a owl:Class ; rdfs:label "obsolete Glucose intolerance" ; owl:deprecated true . obo:HP_0000834 obo:IAO_0000115 "Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys." ; oboInOwl:hasDbXref "MSH:D000307", "SNOMEDCT_US:30171000", "UMLS:C0001621", "UMLS:C4021794" ; oboInOwl:hasExactSynonym "Adrenal abnormalities" ; oboInOwl:hasRelatedSynonym "Adrenal gland disease" ; oboInOwl:id "HP:0000834" ; a owl:Class ; rdfs:label "Abnormality of the adrenal glands" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000835 obo:IAO_0000115 "Developmental hypoplasia of the adrenal glands." ; oboInOwl:hasDbXref "MSH:C538429", "SNOMEDCT_US:237774001", "UMLS:C0342491", "UMLS:C1846223" ; oboInOwl:hasExactSynonym "Adrenal gland hypoplasia", "Hypoplastic adrenal glands", "Small adrenal glands", "Underdeveloped adrenal glands" ; oboInOwl:id "HP:0000835" ; a owl:Class ; rdfs:label "Adrenal hypoplasia" ; rdfs:subClassOf obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000836 obo:IAO_0000115 "An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." ; oboInOwl:hasAlternativeId "HP:0008241" ; oboInOwl:hasDbXref "MSH:D006980", "SNOMEDCT_US:34486009", "UMLS:C0020550" ; oboInOwl:hasExactSynonym "Overactive thyroid" ; oboInOwl:id "HP:0000836" ; a owl:Class ; rdfs:label "Hyperthyroidism" ; rdfs:subClassOf obo:HP_0002926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001625 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000837 obo:IAO_0000115 "Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland." ; oboInOwl:hasAlternativeId "HP:0030340" ; oboInOwl:hasDbXref "UMLS:C1862265" ; oboInOwl:hasExactSynonym "Elevated gonadotropins", "Elevated serum gonadotropins", "Gonadotropin excess", "Increased circulating gonadotropin level" ; oboInOwl:id "HP:0000837" ; a owl:Class ; rdfs:label "Increased circulating gonadotropin level" ; rdfs:subClassOf obo:HP_0010514, obo:HP_0030338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0061696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000839 obo:IAO_0000115 "A type of reduced stature with normal proportions related to dysfunction of the pituitary gland related to either an isolated defect in the secretion of growth hormone or to panhypopituitarism, i.e., a deficit of all the anterior pituitary hormones." ; oboInOwl:hasDbXref "MSH:D004393", "SNOMEDCT_US:367460001", "SNOMEDCT_US:7530009", "UMLS:C0013338" ; oboInOwl:id "HP:0000839" ; a owl:Class ; rdfs:label "Pituitary dwarfism" ; rdfs:subClassOf obo:HP_0004322 . obo:HP_0000840 obo:IAO_0000115 "Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects." ; oboInOwl:hasAlternativeId "HP:0001921" ; oboInOwl:hasDbXref "MSH:D047808", "SNOMEDCT_US:237751000", "SNOMEDCT_US:267395000", "SNOMEDCT_US:271077003", "UMLS:C0302280" ; oboInOwl:id "HP:0000840" ; a owl:Class ; rdfs:label "Adrenogenital syndrome" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0000841 obo:IAO_0000115 "An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms." ; oboInOwl:hasDbXref "UMLS:C1846345", "UMLS:C3150267" ; oboInOwl:hasRelatedSynonym "Increased plasma renin activity" ; oboInOwl:id "HP:0000841" ; a owl:Class ; rdfs:comment "If the kidneys sense reduced renal blood flow, as can happen with reduced blood pressure, they secrete renin into the blood, where it reacts with angiotensinogen to produce angiotensin I, which is converted to angiotensin II by angiotensin converting enzyme (ACE). Both angiotensin I and II are vasoconstrictors. Angiotensin II additionally leads to the production of aldosterone by the adrenal cortex, which in turn leads to an increase in blood volume." ; rdfs:label "Hyperactive renin-angiotensin system" ; rdfs:subClassOf obo:HP_0000847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000760 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018229 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000842 obo:IAO_0000115 "An increased concentration of insulin in the blood." ; oboInOwl:hasDbXref "MSH:D006946", "SNOMEDCT_US:83469008", "UMLS:C0020459" ; oboInOwl:hasExactSynonym "Elevated insulin level" ; oboInOwl:id "HP:0000842" ; a owl:Class ; rdfs:label "Hyperinsulinemia" ; rdfs:subClassOf obo:HP_0011014, obo:HP_0040214 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009054 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000843 obo:IAO_0000115 "Excessive production of parathyroid hormone (PTH) by the parathyroid glands." ; oboInOwl:hasDbXref "MSH:D006961", "SNOMEDCT_US:66999008", "UMLS:C0020502" ; oboInOwl:hasExactSynonym "Elevated blood parathyroid hormone level" ; oboInOwl:id "HP:0000843" ; a owl:Class ; rdfs:label "Hyperparathyroidism" ; rdfs:subClassOf obo:HP_0011767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000845 obo:IAO_0000115 "Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness." ; oboInOwl:hasAlternativeId "HP:0008856" ; oboInOwl:hasDbXref "MSH:C531600", "MSH:D000172", "SNOMEDCT_US:74107003", "UMLS:C0001206", "UMLS:C0235986" ; oboInOwl:hasExactSynonym "Elevated circulating somatotropin concentration", "Growth hormone excess", "Somatotropin excess" ; oboInOwl:id "HP:0000845" ; a owl:Class ; rdfs:comment "Disorder resulting from excess pituitary gland production of growth hormone (hGH)." ; rdfs:label "Elevated circulating growth hormone concentration" ; rdfs:subClassOf obo:HP_0010514, obo:HP_0032367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000846 obo:IAO_0000115 "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands." ; oboInOwl:hasAlternativeId "HP:0000865", "HP:0008218" ; oboInOwl:hasDbXref "MSH:D000309", "SNOMEDCT_US:111563005", "SNOMEDCT_US:237785004", "SNOMEDCT_US:386584007", "UMLS:C0001623" ; oboInOwl:hasExactSynonym "Hypoadrenalism" ; oboInOwl:id "HP:0000846" ; a owl:Class ; rdfs:comment "Adrenal insufficiency may cause persistent vomiting, anorexia, hypoglycemia, poor weight gain in a child, or unexplained weight loss in an adult, malaise, fatigue, muscular weakness, unexplained isotonic or hyponatremic dehydration, hyperkalemia, hypotension, hypoglycemia and especially generalized hyperpigmentation." ; rdfs:label "Adrenal insufficiency" ; rdfs:subClassOf obo:HP_0011733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000847 obo:IAO_0000115 "An abnormality of the renin-angiotensin system." ; oboInOwl:hasAlternativeId "HP:0003350" ; oboInOwl:hasDbXref "UMLS:C4021793" ; oboInOwl:hasExactSynonym "Abnormality of the renin-aldosterone axis" ; oboInOwl:id "HP:0000847" ; a owl:Class ; rdfs:comment "The renin-angiotensin system is a hormone system that regulates blood pressure and water (fluid) balance." ; rdfs:label "Abnormality of renin-angiotensin system" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0018229 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000848 obo:IAO_0000115 "An increased level of renin in the blood." ; oboInOwl:hasAlternativeId "HP:0003615" ; oboInOwl:hasDbXref "UMLS:C0240783" ; oboInOwl:hasExactSynonym "Elevated blood renin level", "Elevated plasma renin", "Hyperreninemia", "Increased plasma renin", "Increased serum renin" ; oboInOwl:id "HP:0000848" ; a owl:Class ; rdfs:label "Increased circulating renin level" ; rdfs:subClassOf obo:HP_0040084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000013883 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000849 oboInOwl:hasDbXref "UMLS:C4025820" ; oboInOwl:id "HP:0000849" ; a owl:Class ; rdfs:label "Adrenocortical abnormality" ; rdfs:subClassOf obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000851 obo:IAO_0000115 "A type of hypothyroidism with congenital onset." ; oboInOwl:hasDbXref "MSH:D003409", "SNOMEDCT_US:190268003", "SNOMEDCT_US:217710005", "UMLS:C0010308" ; oboInOwl:hasExactSynonym "Hypothyroidism, congenital", "Underactive thyroid gland from birth" ; oboInOwl:id "HP:0000851" ; a owl:Class ; rdfs:label "Congenital hypothyroidism" ; rdfs:subClassOf obo:HP_0000821 . obo:HP_0000852 obo:IAO_0000115 "A condition characterized by resistance to the action of parathyroid hormone, in which there is hypocalcemia, hyperphosphatemia, and (appropriately) high levels of parathyroid hormone." ; oboInOwl:hasDbXref "MSH:D011547", "SNOMEDCT_US:58976002", "UMLS:C0033806" ; oboInOwl:id "HP:0000852" ; a owl:Class ; rdfs:label "Pseudohypoparathyroidism" ; rdfs:subClassOf obo:HP_0011767 . obo:HP_0000853 obo:IAO_0000115 "An enlargement of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D006042", "SNOMEDCT_US:3716002", "UMLS:C0018021" ; oboInOwl:hasExactSynonym "Enlarged thyroid gland in neck", "Goitre", "Thyroid goiter", "Thyroid goitre" ; oboInOwl:id "HP:0000853" ; a owl:Class ; rdfs:label "Goiter" ; rdfs:subClassOf obo:HP_0011772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000854 obo:IAO_0000115 "The presence of a adenoma of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D013964", "NCIT:C2855", "SNOMEDCT_US:255033000", "SNOMEDCT_US:255034006", "UMLS:C0151468" ; oboInOwl:id "HP:0000854" ; a owl:Class ; rdfs:label "Thyroid adenoma" ; rdfs:subClassOf obo:HP_0100031 . obo:HP_0000855 obo:IAO_0000115 "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." ; oboInOwl:hasDbXref "MSH:D007333", "SNOMEDCT_US:48606007", "UMLS:C0021655" ; oboInOwl:hasExactSynonym "Body fails to respond to insulin" ; oboInOwl:id "HP:0000855" ; a owl:Class ; rdfs:label "Insulin resistance" ; rdfs:subClassOf obo:HP_0011014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001552 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_5931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000857 oboInOwl:hasDbXref "UMLS:C3278636" ; oboInOwl:id "HP:0000857" ; a owl:Class ; rdfs:label "Neonatal insulin-dependent diabetes mellitus" ; rdfs:subClassOf obo:HP_0000831 . obo:HP_0000858 obo:IAO_0000115 "Abnormally high variation in the amount of time between periods." ; oboInOwl:hasDbXref "SNOMEDCT_US:80182007", "UMLS:C0156404" ; oboInOwl:hasExactSynonym "Irregular menses", "Irregular periods", "Menstrual irregularities", "Menstrual irregularity" ; oboInOwl:id "HP:0000858" ; a owl:Class ; rdfs:comment "Most women have between 11 and 13 menstrual periods each year. Bleeding usually lasts around 5 days (range: 2 to 7 days). When menstruation first starts, it can take up to 2 years to establish a regular cycle. After puberty, most women's menstruation is regular. The length of time between each period is similar. The normal menstrual cycle length is 28 (+/- 7) days days with the menstruation lasting between 2 and 7 days. It can take up to 2 years from menarche to develop a mature hypothalamic-pituitary-gonadal (HPG) axis. Within 1 year, 75 percent of girls have a cycle between 21 and 45 days. By the fifth gynecological year, 90 percent of girls will have regular cycles." ; rdfs:label "Irregular menstruation" ; rdfs:subClassOf obo:HP_0000140 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001845 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0042703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000859 obo:IAO_0000115 "Overproduction of the mineralocorticoid aldosterone by the adrenal cortex." ; oboInOwl:hasAlternativeId "HP:0004318", "HP:0005975" ; oboInOwl:hasDbXref "MSH:D006929", "SNOMEDCT_US:88213004", "UMLS:C0020428" ; oboInOwl:hasExactSynonym "Elevated plasma aldosterone", "Increased aldosterone", "Increased aldosterone production", "Mineralocorticoid excess" ; oboInOwl:id "HP:0000859" ; a owl:Class ; rdfs:label "Hyperaldosteronism" ; rdfs:subClassOf obo:HP_0002717 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000860 obo:IAO_0000115 "Developmental hypoplasia of the parathyroid gland." ; oboInOwl:hasDbXref "UMLS:C1389851" ; oboInOwl:hasExactSynonym "Small parathyroid glands", "Underdeveloped parathyroid glands" ; oboInOwl:id "HP:0000860" ; a owl:Class ; rdfs:label "Parathyroid hypoplasia" ; rdfs:subClassOf obo:HP_0011768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000863 obo:IAO_0000115 "A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus." ; oboInOwl:hasAlternativeId "HP:0008210" ; oboInOwl:hasDbXref "MSH:D020790", "SNOMEDCT_US:45369008", "UMLS:C0687720" ; oboInOwl:hasExactSynonym "Neurohypophyseal diabetes insipidus" ; oboInOwl:id "HP:0000863" ; a owl:Class ; rdfs:label "Central diabetes insipidus" ; rdfs:subClassOf obo:HP_0000873 . obo:HP_0000864 obo:IAO_0000115 "Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit." ; oboInOwl:hasAlternativeId "HP:0000838", "HP:0000844" ; oboInOwl:hasDbXref "UMLS:C4025819" ; oboInOwl:id "HP:0000864" ; a owl:Class ; rdfs:label "Abnormality of the hypothalamus-pituitary axis" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000866 oboInOwl:hasDbXref "UMLS:C1846034" ; oboInOwl:hasExactSynonym "Euthyroid multinodular goitre" ; oboInOwl:id "HP:0000866" ; a owl:Class ; rdfs:label "Euthyroid multinodular goiter" ; rdfs:subClassOf obo:HP_0009798 . obo:HP_0000867 obo:IAO_0000115 "Secondary hyperparathyroidism refers to the production of higher than normal levels of parathyroid hormone in the presence of hypocalcemia." ; oboInOwl:hasDbXref "MSH:D006962", "SNOMEDCT_US:91478007", "UMLS:C0020503" ; oboInOwl:id "HP:0000867" ; a owl:Class ; rdfs:comment "Secondary hyperparathyroidism occurs most commonly secondary to chronic renal failure. Other causes of secondary hyperparathyroidism include osteomalacia, rickets, and malabsorption. The pathophysiology of secondary hyperparathyroidism results from abnormalities in the renal tubular absorption of phosphate with reduced phosphate excretion and hyperphosphatemia, as well as impaired renal conversion of 25-hydroxycholecalciferal to 1,25-dihydroxycholecalciferol, which in turn leads to a decrease in the intestinal absorption of calcium. In combination, elevated serum phosphate levels and reduced vitamin D production result in decreases in serum calcium levels or hypocalcemia, leading to hyperparathyroidism." ; rdfs:label "Secondary hyperparathyroidism" ; rdfs:subClassOf obo:HP_0000843 . obo:HP_0000868 oboInOwl:hasDbXref "UMLS:C0151639" ; oboInOwl:hasExactSynonym "Decreased fertility in females", "Reduced fertility in females" ; oboInOwl:id "HP:0000868" ; a owl:Class ; rdfs:label "Decreased fertility in females" ; rdfs:subClassOf obo:HP_0000144 . obo:HP_0000869 oboInOwl:hasDbXref "SNOMEDCT_US:86030004", "UMLS:C0232940" ; oboInOwl:hasExactSynonym "Previous menstrual periods stop" ; oboInOwl:id "HP:0000869" ; a owl:Class ; rdfs:label "Secondary amenorrhea" ; rdfs:subClassOf obo:HP_0000141 . obo:HP_0000870 obo:IAO_0000115 "The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy." ; oboInOwl:hasDbXref "MSH:D006966", "SNOMEDCT_US:237662005", "UMLS:C0020514" ; oboInOwl:hasExactSynonym "Hyperprolactinaemia", "Hyperprolactinemia", "Prolactin excess" ; oboInOwl:id "HP:0000870" ; a owl:Class ; rdfs:label "Increased circulating prolactin concentration" ; rdfs:subClassOf obo:HP_0010514 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000013246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000871 obo:IAO_0000115 "A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin)." ; oboInOwl:hasDbXref "MSH:C580003", "SNOMEDCT_US:32390006", "UMLS:C0242343" ; oboInOwl:id "HP:0000871" ; a owl:Class ; rdfs:label "Panhypopituitarism" ; rdfs:subClassOf obo:HP_0000830 ; owl:equivalentClass _:genid37751 . obo:HP_0000872 obo:IAO_0000115 "A chronic, autoimmune type of thyroiditis associated with hypothyroidism." ; oboInOwl:hasDbXref "MSH:D050031", "SNOMEDCT_US:21983002", "UMLS:C0677607" ; oboInOwl:hasExactSynonym "Chronic lymphocytic thyroiditis", "Hashimoto's thyroiditis" ; oboInOwl:id "HP:0000872" ; a owl:Class ; rdfs:label "Hashimoto thyroiditis" ; rdfs:subClassOf obo:HP_0002960, obo:HP_0100646 . obo:HP_0000873 obo:IAO_0000115 "A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus)." ; oboInOwl:hasDbXref "MSH:D003919", "SNOMEDCT_US:15771004", "UMLS:C0011848" ; oboInOwl:id "HP:0000873" ; a owl:Class ; rdfs:label "Diabetes insipidus" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000875 oboInOwl:hasDbXref "UMLS:C1857175" ; oboInOwl:hasExactSynonym "Intermittent high blood pressure" ; oboInOwl:id "HP:0000875" ; a owl:Class ; rdfs:label "Episodic hypertension" ; rdfs:subClassOf obo:HP_0000822 . obo:HP_0000876 obo:IAO_0000115 "Infrequent menses (less than 6 per year or more than 35 days between cycles)." ; oboInOwl:hasDbXref "MSH:D009839", "SNOMEDCT_US:52073004", "UMLS:C0028949" ; oboInOwl:hasExactSynonym "Light or infrequent menstrual periods" ; oboInOwl:id "HP:0000876" ; a owl:Class ; rdfs:label "Oligomenorrhea" ; rdfs:subClassOf obo:HP_0000140 . obo:HP_0000877 oboInOwl:hasDbXref "UMLS:C1837792" ; oboInOwl:hasExactSynonym "Insulin-resistant diabetes mellitus at puberty" ; oboInOwl:id "HP:0000877" ; a owl:Class ; rdfs:label "Insulin-resistant diabetes mellitus at puberty" ; rdfs:subClassOf obo:HP_0000831 . obo:HP_0000878 obo:IAO_0000115 "Presence of only 11 pairs of ribs." ; oboInOwl:hasDbXref "UMLS:C1839731" ; oboInOwl:hasExactSynonym "11 pairs of ribs" ; oboInOwl:id "HP:0000878" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Normally, there are 12 pairs of ribs." ; rdfs:label "11 pairs of ribs" ; rdfs:subClassOf obo:HP_0000921 . obo:HP_0000879 obo:IAO_0000115 "Decreased inferosuperior length of the sternum." ; oboInOwl:hasDbXref "SNOMEDCT_US:298724002", "UMLS:C0575497", "UMLS:C4020883" ; oboInOwl:hasExactSynonym "Short sternum" ; oboInOwl:hasRelatedSynonym "Hypoplastic sternum" ; oboInOwl:id "HP:0000879" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short sternum" ; rdfs:subClassOf obo:HP_0006714 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000882 obo:IAO_0000115 "Underdeveloped scapula." ; oboInOwl:hasAlternativeId "HP:0000906", "HP:0006616" ; oboInOwl:hasDbXref "UMLS:C1846434" ; oboInOwl:hasExactSynonym "Hypoplastic scapula", "Scapular hypoplasia", "Short scapulae", "Small scapula", "Small scapulae", "Small shoulder blade" ; oboInOwl:id "HP:0000882" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic scapulae" ; rdfs:subClassOf obo:HP_0006713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006849 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000883 obo:IAO_0000115 "Ribs with a reduced diameter." ; oboInOwl:hasDbXref "SNOMEDCT_US:249697003", "UMLS:C0426818" ; oboInOwl:hasExactSynonym "Slender ribs", "Thin ribs" ; oboInOwl:id "HP:0000883" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thin ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000884 oboInOwl:hasDbXref "UMLS:C1846433" ; oboInOwl:hasExactSynonym "Prominent sternum", "Sternal protrusion" ; oboInOwl:id "HP:0000884" ; a owl:Class ; rdfs:label "Prominent sternum" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000885 obo:IAO_0000115 "Increased width of ribs" ; oboInOwl:hasAlternativeId "HP:0000903", "HP:0000950", "HP:0006667" ; oboInOwl:hasDbXref "UMLS:C1848654" ; oboInOwl:hasExactSynonym "Broad ribs", "Wide ribs" ; oboInOwl:id "HP:0000885" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000886 obo:IAO_0000115 "Malformation of the rib cage." ; oboInOwl:hasDbXref "UMLS:C1838659" ; oboInOwl:hasExactSynonym "Deformed rib cage" ; oboInOwl:id "HP:0000886" ; a owl:Class ; rdfs:label "Deformed rib cage" ; rdfs:subClassOf obo:HP_0001547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000887 obo:IAO_0000115 "Wide, concave rib end." ; oboInOwl:hasAlternativeId "HP:0006635" ; oboInOwl:hasDbXref "SNOMEDCT_US:249704008", "UMLS:C0426826", "UMLS:C1865039" ; oboInOwl:hasExactSynonym "Cupped ribs", "Rib cupping" ; oboInOwl:hasRelatedSynonym "Rib flaring" ; oboInOwl:id "HP:0000887" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cupped ribs" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0000888 obo:IAO_0000115 "A horizontal (flat) conformation of the ribs, the long curved bones that form the rib cage and normally progressively oblique (slanted) from ribs 1 through 9, then less slanted through rib 12." ; oboInOwl:hasDbXref "UMLS:C3806510" ; oboInOwl:hasExactSynonym "Horizontal ribs" ; oboInOwl:id "HP:0000888" ; a owl:Class ; rdfs:label "Horizontal ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001855 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000889 obo:IAO_0000115 "Any abnormality of the clavicles (collar bones)." ; oboInOwl:hasDbXref "UMLS:C4021792" ; oboInOwl:hasExactSynonym "Abnormal clavicles", "Abnormal collarbone", "Abnormality of the clavicle" ; oboInOwl:id "HP:0000889" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal clavicle morphology" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000890 obo:IAO_0000115 "Increased length of the clavicles." ; oboInOwl:hasAlternativeId "HP:0006592" ; oboInOwl:hasDbXref "SNOMEDCT_US:249687007", "UMLS:C0426808" ; oboInOwl:hasExactSynonym "Elongated clavicles", "Long collarbone" ; oboInOwl:id "HP:0000890" ; a owl:Class ; rdfs:label "Long clavicles" ; rdfs:subClassOf obo:HP_0000889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000891 oboInOwl:hasDbXref "MSH:D057070", "SNOMEDCT_US:72535009", "UMLS:C0158779" ; oboInOwl:id "HP:0000891" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cervical ribs" ; rdfs:subClassOf obo:HP_0005815 . obo:HP_0000892 obo:IAO_0000115 "A bifid rib refers to cleavage of the sternal end of a rib, usually unilateral. Bifid ribs are usually asymptomatic, and are often discovered incidentally by chest x-ray." ; oboInOwl:hasDbXref "UMLS:C4721788" ; oboInOwl:hasExactSynonym "Cleft ribs", "Split ribs" ; oboInOwl:id "HP:0000892" ; a owl:Class ; rdfs:label "Bifid ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000893 obo:IAO_0000115 "Abnormal outward curving (protuberance) of the junction of ribs and costal cartilage." ; oboInOwl:hasDbXref "UMLS:C1848538" ; oboInOwl:id "HP:0000893" ; a owl:Class ; rdfs:comment "The costochondral junction is the structure where the ribs articulate with the sternum." ; rdfs:label "Bulging of the costochondral junction" ; rdfs:subClassOf obo:HP_0000766, obo:HP_0000919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000894 obo:IAO_0000115 "Reduced length of the clavicles." ; oboInOwl:hasAlternativeId "HP:0000898", "HP:0005698", "HP:0005902" ; oboInOwl:hasDbXref "SNOMEDCT_US:93250003", "UMLS:C0426799" ; oboInOwl:hasExactSynonym "Clavicular hypoplasia", "Hypoplastic clavicles", "Short collarbone", "Underdeveloped clavicles" ; oboInOwl:id "HP:0000894" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short clavicles" ; rdfs:subClassOf obo:HP_0006710 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000895 obo:IAO_0000115 "An excessive upward convexity of the lateral clavicle." ; oboInOwl:hasDbXref "SNOMEDCT_US:249684000", "UMLS:C0426805" ; oboInOwl:hasExactSynonym "Handlebar clavicle", "Hook-shaped clavicle", "Hook-shaped collarbone", "Hooked clavicle" ; oboInOwl:id "HP:0000895" ; a owl:Class ; rdfs:label "Lateral clavicle hook" ; rdfs:subClassOf obo:HP_0000889 . obo:HP_0000896 obo:IAO_0000115 "Multiple circumscribed bony excrescences located in the ribs." ; oboInOwl:hasDbXref "UMLS:C1835579" ; oboInOwl:id "HP:0000896" ; a owl:Class ; rdfs:label "Rib exostoses" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0100777 . obo:HP_0000897 obo:IAO_0000115 "A row of beadlike prominences at the junction of a rib and its cartilage (i.e., enlarged costochondral joints), resembling a rosary." ; oboInOwl:hasDbXref "SNOMEDCT_US:15214001", "SNOMEDCT_US:249702007" ; oboInOwl:id "HP:0000897" ; a owl:Class ; rdfs:comment "Nutritional rickets (NR), secondary to vitamin D deficiency and/or dietary calcium deficiency, is characterized by a range of features including 1) hypocalcemic seizures and tetanic spasms; 2) life-threatening hypocalcemic cardiomyopathy; 3) bone pain and muscle weakness; 4) limb and pelvic deformities; 5) failure to thrive; 6) developmental delay; and 7) dental anomalies. Rickets can additionally be caused by genetic defects such as a defect in the vitamin D receptor gene." ; rdfs:label "Rachitic rosary" ; rdfs:subClassOf obo:HP_0000766, obo:HP_0000919 . obo:HP_0000900 obo:IAO_0000115 "Increased thickness (diameter) of ribs." ; oboInOwl:hasDbXref "SNOMEDCT_US:249699000", "UMLS:C0426820" ; oboInOwl:id "HP:0000900" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thickened ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000902 obo:IAO_0000115 "Complete or partial merging of adjacent ribs." ; oboInOwl:hasAlternativeId "HP:0000880" ; oboInOwl:hasDbXref "UMLS:C1844749" ; oboInOwl:hasExactSynonym "Fused ribs", "Rib fusion" ; oboInOwl:id "HP:0000902" ; a owl:Class ; rdfs:label "Rib fusion" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000904 obo:IAO_0000115 "The presence of wide, concave anterior rib ends." ; oboInOwl:hasAlternativeId "HP:0006656" ; oboInOwl:hasDbXref "UMLS:C1854780" ; oboInOwl:hasExactSynonym "Anterior flaring of ribs", "Flaring of rib cage" ; oboInOwl:id "HP:0000904" ; a owl:Class ; rdfs:label "Flaring of rib cage" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000905 obo:IAO_0000115 "Progressive bone resorption in the distal part of the clavicle." ; oboInOwl:hasDbXref "UMLS:C1837757" ; oboInOwl:hasExactSynonym "Progressive acroosteolysis of the clavicle" ; oboInOwl:id "HP:0000905" ; a owl:Class ; rdfs:label "Progressive clavicular acroosteolysis" ; rdfs:subClassOf obo:HP_0000889, obo:HP_0002797 . obo:HP_0000907 obo:IAO_0000115 "Wide, concave anterior rib end." ; oboInOwl:hasAlternativeId "HP:0006601" ; oboInOwl:hasDbXref "UMLS:C1846154" ; oboInOwl:hasExactSynonym "Anterior cupping of ribs", "Anteriorly splayed ribs" ; oboInOwl:id "HP:0000907" ; a owl:Class ; rdfs:label "Anterior rib cupping" ; rdfs:subClassOf obo:HP_0000887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002154 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000910 oboInOwl:hasDbXref "UMLS:C1861213" ; oboInOwl:id "HP:0000910" ; a owl:Class ; rdfs:label "Wide-cupped costochondral junctions" ; rdfs:subClassOf obo:HP_0000919 . obo:HP_0000911 obo:IAO_0000115 "Abnormally flat configuration of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." ; oboInOwl:hasDbXref "UMLS:C1855177" ; oboInOwl:id "HP:0000911" ; a owl:Class ; rdfs:comment "See PMID:15163819, figure 2, for the arthrographic appearance of a flat glenoid fossa." ; rdfs:label "Flat glenoid fossa" ; rdfs:subClassOf obo:HP_0011912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000912 obo:IAO_0000115 "A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other)." ; oboInOwl:hasAlternativeId "HP:0006621" ; oboInOwl:hasDbXref "MEDDRA:10010455", "MSH:C535802", "SNOMEDCT_US:79120002", "UMLS:C0152438" ; oboInOwl:hasExactSynonym "Congenital, upward displacement of the scapula", "High scapula", "High shoulder blade", "Sprengel deformity" ; oboInOwl:id "HP:0000912" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Sprengel deformity is associated with malposition and dysplasia of the scapula and also involves regional muscle hypoplasia or atrophy, which causes disfigurement and limitation of shoulder movement. Sprengel deformity may be unilateral or bilateral and occur in isolation or as a syndromic component. Abduction of shoulder beyond 90 degrees is impossible." ; rdfs:label "Sprengel anomaly" ; rdfs:subClassOf obo:HP_0000782 . obo:HP_0000913 obo:IAO_0000115 "Complete or partial merging of the posterior part of adjacent ribs." ; oboInOwl:hasDbXref "UMLS:C1842084" ; oboInOwl:id "HP:0000913" ; a owl:Class ; rdfs:label "Posterior rib fusion" ; rdfs:subClassOf obo:HP_0000902 . obo:HP_0000914 obo:IAO_0000115 "A broad chest." ; oboInOwl:hasDbXref "UMLS:C1834124", "UMLS:C1839248" ; oboInOwl:hasExactSynonym "Shield chest" ; oboInOwl:hasRelatedSynonym "Broad chest" ; oboInOwl:id "HP:0000914" ; a owl:Class ; rdfs:comment "Stretching of the thoracic cage as a result of fetal edema may contribute to the shield chest with widely spaced nipples that can be obsered in persons with Turner syndrome." ; rdfs:label "Shield chest" ; rdfs:subClassOf obo:HP_0100625 . obo:HP_0000915 obo:IAO_0000115 "Pectus excavatum (defect of the chest wall characterized by depression of the sternum) affecting primarily the inferior region of the sternum." ; oboInOwl:hasDbXref "UMLS:C1864796" ; oboInOwl:hasExactSynonym "Pectus excavatum inferiorly" ; oboInOwl:id "HP:0000915" ; a owl:Class ; rdfs:label "Pectus excavatum of inferior sternum" ; rdfs:subClassOf obo:HP_0000767 . obo:HP_0000916 obo:IAO_0000115 "Increased width (cross-sectional diameter) of the clavicles." ; oboInOwl:hasAlternativeId "HP:0006651" ; oboInOwl:hasDbXref "SNOMEDCT_US:249680009", "UMLS:C0426801" ; oboInOwl:hasExactSynonym "Broad collarbone" ; oboInOwl:id "HP:0000916" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad clavicles" ; rdfs:subClassOf obo:HP_0000889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000917 obo:IAO_0000115 "Pectus carinatum affecting primarily the superior part of the sternum." ; oboInOwl:hasDbXref "UMLS:C1864795" ; oboInOwl:hasExactSynonym "Pectus carinatum superiorly" ; oboInOwl:id "HP:0000917" ; a owl:Class ; rdfs:label "Superior pectus carinatum" ; rdfs:subClassOf obo:HP_0000768 . obo:HP_0000918 obo:IAO_0000115 "The presence of multiple exostoses on the scapula. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage." ; oboInOwl:hasDbXref "UMLS:C1851415" ; oboInOwl:hasExactSynonym "Scapulae exostoses", "Shoulder bone exostoes" ; oboInOwl:id "HP:0000918" ; a owl:Class ; rdfs:label "Scapular exostoses" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0100777 . obo:HP_0000919 obo:IAO_0000115 "Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." ; oboInOwl:hasDbXref "UMLS:C4021791" ; oboInOwl:hasExactSynonym "Costochondral juctions abnormal" ; oboInOwl:id "HP:0000919" ; a owl:Class ; rdfs:comment "The first seven pairs of ribs are connected with the sternum; the next three ribs are each articulated with the lower border of the cartilage of the preceding rib; the last two ribs have pointed extremities, which do not connect with the sternum." ; rdfs:label "Abnormality of the costochondral junction" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000920 obo:IAO_0000115 "Abnormally increased size of the costochondral junctions, which are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." ; oboInOwl:hasAlternativeId "HP:0006620" ; oboInOwl:hasDbXref "UMLS:C1857180" ; oboInOwl:hasExactSynonym "Costochondral thickening", "Enlarged costochondral junctions", "Prominent costochondral junction", "Wide costochondral junctions", "Widened costochondral junction" ; oboInOwl:id "HP:0000920" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Enlargement of the costochondral junction" ; rdfs:subClassOf obo:HP_0000919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000921 obo:IAO_0000115 "A developmental anomaly with absence of one or more ribs." ; oboInOwl:hasAlternativeId "HP:0000881", "HP:0006627" ; oboInOwl:hasDbXref "SNOMEDCT_US:249695006", "UMLS:C0426816" ; oboInOwl:hasExactSynonym "Absent ribs", "Decreased rib number", "Missing ribs" ; oboInOwl:id "HP:0000921" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Missing ribs" ; rdfs:subClassOf obo:HP_0006712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000922 obo:IAO_0000115 "Wide, concave posterior rib end." ; oboInOwl:hasAlternativeId "HP:0006622" ; oboInOwl:hasDbXref "UMLS:C1837483" ; oboInOwl:hasExactSynonym "Anterior and posterior rib cupping" ; oboInOwl:id "HP:0000922" ; a owl:Class ; rdfs:label "Posterior rib cupping" ; rdfs:subClassOf obo:HP_0000887 . obo:HP_0000923 obo:IAO_0000115 "The presence of a row of multiple rounded expansions (beadlike prominences) at the junction of a rib and its cartilage." ; oboInOwl:hasDbXref "UMLS:C0426824" ; oboInOwl:id "HP:0000923" ; a owl:Class ; rdfs:comment "Beaded ribs, sometimes referred to as rachitic rosary, were often seen in rachitic children." ; rdfs:label "Beaded ribs" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0000924 obo:IAO_0000115 "An abnormality of the skeletal system." ; oboInOwl:hasDbXref "UMLS:C4021790" ; oboInOwl:hasExactSynonym "Abnormality of the skeletal system", "Skeletal abnormalities", "Skeletal anomalies" ; oboInOwl:id "HP:0000924" ; a owl:Class ; rdfs:label "Abnormality of the skeletal system" ; rdfs:subClassOf obo:HP_0033127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001434 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000925 obo:IAO_0000115 "Any abnormality of the vertebral column." ; oboInOwl:hasDbXref "UMLS:C4020882", "UMLS:C4021789" ; oboInOwl:hasExactSynonym "Abnormal spine", "Abnormal vertebral column", "Abnormality of the spine", "Abnormality of the vertebral column" ; oboInOwl:hasRelatedSynonym "Abnormality of the backbone" ; oboInOwl:id "HP:0000925" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the vertebral column" ; rdfs:subClassOf obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000926 obo:IAO_0000115 "A flattened vertebral body shape with reduced distance between the vertebral endplates." ; oboInOwl:hasAlternativeId "HP:0002940", "HP:0003421", "HP:0004595", "HP:0004623", "HP:0004627", "HP:0005123", "HP:0005644", "HP:0008466" ; oboInOwl:hasDbXref "UMLS:C1844704" ; oboInOwl:hasExactSynonym "Flat vertebral bodies", "Flattened vertebrae", "Flattened vertebral bodies" ; oboInOwl:id "HP:0000926" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Platyspondyly" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0000927 obo:IAO_0000115 "The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation." ; oboInOwl:hasDbXref "UMLS:C4025818" ; oboInOwl:hasExactSynonym "Abnormality of skeletal maturation" ; oboInOwl:id "HP:0000927" ; a owl:Class ; rdfs:label "Abnormality of skeletal maturation" ; rdfs:subClassOf obo:HP_0011843 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070977 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004288 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000929 obo:IAO_0000115 "An abnormality of the skull, the bony framework of the head which is comprised of the neurocranium (with eight cranial bones) and the viscerocranium (facial skeleton) that comprises fourteen facial bones with the mandible as its largest bone." ; oboInOwl:hasDbXref "UMLS:C0235942" ; oboInOwl:hasExactSynonym "Abnormality of the skull" ; oboInOwl:hasNarrowSynonym "Abnormality of the skull bones" ; oboInOwl:id "HP:0000929" ; a owl:Class ; rdfs:label "Abnormal skull morphology" ; rdfs:subClassOf obo:HP_0000234, obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000930 oboInOwl:hasDbXref "UMLS:C4025817" ; oboInOwl:hasExactSynonym "Elevated imprint of occipital bone over the transverse sinuses", "Elevated imprint of posterior skull bones over the transverse sinuses", "Thinning and bulging of occipital bone over the transverse sinuses", "Thinning and bulging of posterior skull bones over the transverse sinuses" ; oboInOwl:id "HP:0000930" ; a owl:Class ; rdfs:label "Elevated imprint of the transverse sinuses" ; rdfs:subClassOf obo:HP_0002693 . obo:HP_0000931 oboInOwl:hasDbXref "UMLS:C4021788", "UMLS:C4280608" ; oboInOwl:hasExactSynonym "Thinning and bulging of posterior fossa bones", "Thinning and bulging of posterior skull bones" ; oboInOwl:hasNarrowSynonym "Thinning and bulging of occipital bone of skull" ; oboInOwl:id "HP:0000931" ; a owl:Class ; rdfs:label "Thinning and bulging of the posterior fossa bones" ; rdfs:subClassOf obo:HP_0000932 . obo:HP_0000932 obo:IAO_0000115 "An abnormality of the fossa cranii posterior (the posterior fossa), which is made up primarily of the occipital bone and which surrounds to the foramen magnum." ; oboInOwl:hasAlternativeId "HP:0007306" ; oboInOwl:hasDbXref "UMLS:C3280768" ; oboInOwl:hasExactSynonym "Abnormality of the posterior cranial fossa", "Abnormality of the posterior fossa", "Posterior fossa anomaly" ; oboInOwl:id "HP:0000932" ; a owl:Class ; rdfs:comment "The floor of the cranial cavity is divided into three distinct depressions called the anterior, middle, and posterior cranial fossa. The posterior cranial fossa, the most posterior and deep of the three cranial fossae, accommodates the brainstem and cerebellum. Abnormalities of the posterier cranial fossa can be demonstrated by cerebral magnetic resonance imaging or computer tomography." ; rdfs:label "Abnormal posterior cranial fossa morphology" ; rdfs:subClassOf obo:HP_0002693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008788 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000933 oboInOwl:hasDbXref "UMLS:C4025816" ; oboInOwl:id "HP:0000933" ; a owl:Class ; rdfs:label "Posterior fossa cyst at the fourth ventricle" ; rdfs:subClassOf obo:HP_0007109, obo:HP_0007291 . obo:HP_0000934 obo:IAO_0000115 "Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) ." ; oboInOwl:hasDbXref "MSH:D002805", "SNOMEDCT_US:201637001", "SNOMEDCT_US:239832006", "SNOMEDCT_US:239838005", "UMLS:C0553730" ; oboInOwl:hasExactSynonym "Calcium deposits in joints" ; oboInOwl:id "HP:0000934" ; a owl:Class ; rdfs:label "Chondrocalcinosis" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0010766, obo:HP_0100685 . obo:HP_0000935 obo:IAO_0000115 "Abnormal thickening of the cortex of long bones." ; oboInOwl:hasDbXref "UMLS:C1840418" ; oboInOwl:hasExactSynonym "Broad cortex of long bones", "Cortical thickening of the long bones", "Thickened cortices of long bones" ; oboInOwl:id "HP:0000935" ; a owl:Class ; rdfs:label "Thickened cortex of long bones" ; rdfs:subClassOf obo:HP_0011314, obo:HP_0100039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000938 obo:IAO_0000115 "Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5." ; oboInOwl:hasAlternativeId "HP:0002768", "HP:0002799", "HP:0002800" ; oboInOwl:hasDbXref "MSH:D001851", "SNOMEDCT_US:312894000", "SNOMEDCT_US:78441005", "UMLS:C0029453", "UMLS:C0747078" ; oboInOwl:hasExactSynonym "Generalised osteopenia", "Generalized osteopenia", "Osteopaenia" ; oboInOwl:id "HP:0000938" ; a owl:Class ; rdfs:label "Osteopenia" ; rdfs:subClassOf obo:HP_0004349 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001790 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0000939 obo:IAO_0000115 "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD)." ; oboInOwl:hasAlternativeId "HP:0002774" ; oboInOwl:hasDbXref "MSH:D010024", "SNOMEDCT_US:64859006", "UMLS:C0029456" ; oboInOwl:id "HP:0000939" ; a owl:Class ; rdfs:comment "Osteoporosis is a disease that is characterized by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture: it can lead to compromised bone strength and an increase in the risk of fractures." ; rdfs:label "Osteoporosis" ; rdfs:subClassOf obo:HP_0004349 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0000940 obo:IAO_0000115 "An abnormality of the structure or form of the diaphysis, i.e., of the main or mid-section (shaft) of a long bone." ; oboInOwl:hasAlternativeId "HP:0006504" ; oboInOwl:hasDbXref "UMLS:C4021787" ; oboInOwl:hasExactSynonym "Abnormal shape of shaft of long bone", "Abnormality involving the diaphyses of the limbs", "Abnormality of shaft of long bone of the limbs", "Abnormality of the diaphyses", "Anomaly of the limb diaphyses", "Anomaly of the limb diaphyses morphology" ; oboInOwl:id "HP:0000940" ; a owl:Class ; rdfs:label "Abnormal diaphysis morphology" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000941 oboInOwl:hasDbXref "UMLS:C4025815" ; oboInOwl:hasExactSynonym "Short shaft of long bone" ; oboInOwl:id "HP:0000941" ; a owl:Class ; rdfs:label "Short diaphyses" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000943 oboInOwl:hasAlternativeId "HP:0002760" ; oboInOwl:hasDbXref "MSH:D008059", "SNOMEDCT_US:254069004", "SNOMEDCT_US:65327002", "UMLS:C0086795" ; oboInOwl:id "HP:0000943" ; a owl:Class ; rdfs:label "Dysostosis multiplex" ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0000944 obo:IAO_0000115 "An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood." ; oboInOwl:hasAlternativeId "HP:0006506" ; oboInOwl:hasDbXref "UMLS:C4025814" ; oboInOwl:hasExactSynonym "Abnormality of the wide portion of a long bone" ; oboInOwl:id "HP:0000944" ; a owl:Class ; rdfs:label "Abnormal metaphysis morphology" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000946 obo:IAO_0000115 "Underdevelopment of the ilium." ; oboInOwl:hasAlternativeId "HP:0003176", "HP:0003178" ; oboInOwl:hasBroadSynonym "Small wings of the pelvic girdle" ; oboInOwl:hasDbXref "UMLS:C1861218", "UMLS:C4280607" ; oboInOwl:hasExactSynonym "Short and small iliac bones", "Small iliac bones" ; oboInOwl:id "HP:0000946" ; a owl:Class ; rdfs:label "Hypoplastic ilia" ; rdfs:subClassOf obo:HP_0002867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000947 obo:IAO_0000115 "An abnormal appearance of the long bones with resemblance to a dumbbell, a short bar with a weight at each end. That is, the long bone is shortened and displays flaring (widening) of the metaphyses." ; oboInOwl:hasAlternativeId "HP:0005061", "HP:0005071", "HP:0005075" ; oboInOwl:hasDbXref "UMLS:C2749582" ; oboInOwl:hasExactSynonym "Dumbbell widening of long bone metaphyses", "Dumbbell-shaped long bone" ; oboInOwl:id "HP:0000947" ; a owl:Class ; rdfs:label "Dumbbell-shaped long bone" ; rdfs:subClassOf obo:HP_0003016 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001876 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000951 obo:IAO_0000115 "An abnormality of the skin." ; oboInOwl:hasAlternativeId "HP:0001478", "HP:0001479", "HP:0005591", "HP:0006736", "HP:0007415", "HP:0007580" ; oboInOwl:hasDbXref "MSH:D012868", "MSH:D012871", "SNOMEDCT_US:199879009", "SNOMEDCT_US:95320005", "UMLS:C0037268", "UMLS:C0037274" ; oboInOwl:hasExactSynonym "Abnormality of the skin", "Dermatopathy", "Dermopathy" ; oboInOwl:hasRelatedSynonym "Skin abnormality" ; oboInOwl:id "HP:0000951" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the skin" ; rdfs:subClassOf obo:HP_0001574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000952 obo:IAO_0000115 "Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." ; oboInOwl:hasDbXref "MSH:D007565", "SNOMEDCT_US:18165001", "UMLS:C0022346" ; oboInOwl:hasExactSynonym "Icterus", "Jaundice", "Yellow skin", "Yellowing of the skin" ; oboInOwl:id "HP:0000952" ; a owl:Class ; rdfs:label "Jaundice" ; rdfs:subClassOf obo:HP_0001005, obo:HP_0001396 . obo:HP_0000953 obo:IAO_0000115 "A darkening of the skin related to an increase in melanin production and deposition." ; oboInOwl:hasAlternativeId "HP:0007527" ; oboInOwl:hasDbXref "MSH:D017495", "SNOMEDCT_US:4830009", "SNOMEDCT_US:49765009", "UMLS:C0162834" ; oboInOwl:hasExactSynonym "Cutaneous hyperpigmentation", "Hyperpigmented lesion", "Increased skin pigmentation", "Patchy darkened skin", "Skin hyperpigmentation" ; oboInOwl:hasRelatedSynonym "Melanoderma", "Melanodermia" ; oboInOwl:id "HP:0000953" ; a owl:Class ; rdfs:label "Hyperpigmentation of the skin" ; rdfs:subClassOf obo:HP_0001000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000954 obo:IAO_0000115 "The distal and proximal transverse palmar creases are merged into a single transverse palmar crease." ; oboInOwl:hasAlternativeId "HP:0006214" ; oboInOwl:hasDbXref "SNOMEDCT_US:248409006", "UMLS:C0424731" ; oboInOwl:hasExactSynonym "Simian crease", "Simian creases", "Simian line", "Single flexion crease", "Single palmar crease", "Single palmar creases", "Single transverse palmar creases", "Transverse palmar crease" ; oboInOwl:id "HP:0000954" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The presence of a single palmar crease (instead of the two palmar creases that are typically present)." ; rdfs:label "Single transverse palmar crease" ; rdfs:subClassOf obo:HP_0010490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000956 obo:IAO_0000115 "A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck." ; oboInOwl:hasAlternativeId "HP:0007498", "HP:0007518", "HP:0007591" ; oboInOwl:hasDbXref "MSH:D000052", "SNOMEDCT_US:402599005", "SNOMEDCT_US:72129000", "UMLS:C0000889" ; oboInOwl:hasExactSynonym "Darkened and thickened skin", "Keratosis nigricans" ; oboInOwl:id "HP:0000956" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:comment "Acanthosis nigricans is seen in a variety of syndromes including those characterized by insulin resistance or fibroblast growth factor receptor (FGFR) mutations, and may also occur as an adverse effect of several medications that promote hyperinsulinemia." ; rdfs:label "Acanthosis nigricans" ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0000957 obo:IAO_0000115 "Cafe-au-lait spots are hyperpigmented lesions that can vary in color from light brown to dark brown with smooth borders and having a size of 1.5 cm or more in adults and 0.5 cm or more in children." ; oboInOwl:hasAlternativeId "HP:0005601", "HP:0007454" ; oboInOwl:hasBroadSynonym "Birthmark", "Flat light-brown mark on skin" ; oboInOwl:hasDbXref "MSH:D019080", "SNOMEDCT_US:201281002", "SNOMEDCT_US:51089004", "UMLS:C0221263", "UMLS:C0265974" ; oboInOwl:hasExactSynonym "Cafe au lait spots", "Cafe-au-lait macule", "Cafe-au-lait macules" ; oboInOwl:hasRelatedSynonym "Cafe-au-lait spots" ; oboInOwl:id "HP:0000957" ; a owl:Class ; rdfs:comment "The phrase cafe-au-lait comes from the French word for milk-coffee. A single cafe-au-lait spot can be an isolated finding in otherwise normal individuals. Multiple cafe-au-lait spots often indicate the presence of neurofibromatosis type 1 but may also be seen in other diseases including McCune-Albright syndrome, tuberous sclerosis, and Fanconi anemia." ; rdfs:label "Cafe-au-lait spot" ; rdfs:subClassOf obo:HP_0001034 . obo:HP_0000958 obo:IAO_0000115 "Skin characterized by the lack of natural or normal moisture." ; oboInOwl:hasDbXref "MEDDRA:10048222", "SNOMEDCT_US:16386004", "UMLS:C0151908", "UMLS:C0259817" ; oboInOwl:hasExactSynonym "Dry skin", "Xerosis" ; oboInOwl:id "HP:0000958" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dry skin" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001801 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000960 obo:IAO_0000115 "A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the intergluteal cleft." ; oboInOwl:hasDbXref "SNOMEDCT_US:249729002", "SNOMEDCT_US:311897005", "UMLS:C0426848" ; oboInOwl:hasExactSynonym "Pilonidal dimple", "Spinal dimple" ; oboInOwl:id "HP:0000960" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sacral dimple" ; rdfs:subClassOf obo:HP_0010767, obo:HP_0010781 . obo:HP_0000961 obo:IAO_0000115 "Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood." ; oboInOwl:hasDbXref "MSH:D003490", "SNOMEDCT_US:119419001", "SNOMEDCT_US:3415004", "UMLS:C0010520" ; oboInOwl:hasExactSynonym "Blue discoloration of the skin" ; oboInOwl:id "HP:0000961" ; a owl:Class ; rdfs:label "Cyanosis" ; rdfs:subClassOf obo:HP_0001005 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000319 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000962 obo:IAO_0000115 "Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum." ; oboInOwl:hasAlternativeId "HP:0007523" ; oboInOwl:hasDbXref "MEDDRA:10020649", "SNOMEDCT_US:26996000", "SNOMEDCT_US:396228006", "SNOMEDCT_US:399955009", "UMLS:C0870082" ; oboInOwl:id "HP:0000962" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hyperkeratosis" ; rdfs:subClassOf obo:HP_0011368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000963 obo:IAO_0000115 "Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin." ; oboInOwl:hasAlternativeId "HP:0001020" ; oboInOwl:hasDbXref "SNOMEDCT_US:277797007", "UMLS:C0423757" ; oboInOwl:hasExactSynonym "Thin skin" ; oboInOwl:id "HP:0000963" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thin skin" ; rdfs:subClassOf obo:HP_0008065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000964 obo:IAO_0000115 "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." ; oboInOwl:hasAlternativeId "HP:0001481" ; oboInOwl:hasDbXref "MSH:D004485", "SNOMEDCT_US:281104002", "SNOMEDCT_US:43116000", "UMLS:C0013595" ; oboInOwl:hasExactSynonym "Eczema" ; oboInOwl:id "HP:0000964" ; a owl:Class ; rdfs:comment "Eczema has several forms including atopic dermatitis, contact dermatitis, dyshidrotic eczema, nummular eczema, seborrheic dermatitis, and stasis dermatitis." ; rdfs:label "Eczema" ; rdfs:subClassOf obo:HP_0011123 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000965 obo:IAO_0000115 "A reticular discoloration of the skin with cyanotic (reddish-blue appearing) areas surrounding pale central areas due to dilation of capillary blood vessels and stagnation of blood within the vessels. Cutis marmorata generally occurs on the legs, arms and trunk and is often more severe in cold weather." ; oboInOwl:hasAlternativeId "HP:0001037" ; oboInOwl:hasDbXref "UMLS:C0263401" ; oboInOwl:id "HP:0000965" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cutis marmorata" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0000966 obo:IAO_0000115 "Abnormally diminished capacity to sweat." ; oboInOwl:hasAlternativeId "HP:0007551", "HP:0007571" ; oboInOwl:hasDbXref "MEDDRA:10021013", "MSH:D007007", "SNOMEDCT_US:45004005", "UMLS:C0020620" ; oboInOwl:hasExactSynonym "Decreased ability to sweat", "Decreased sweating", "Inadequate sweating", "Oligohidrosis", "Sweating, decreased" ; oboInOwl:id "HP:0000966" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypohidrosis" ; rdfs:subClassOf obo:HP_0007550 . obo:HP_0000967 obo:IAO_0000115 "Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae." ; oboInOwl:hasDbXref "MEDDRA:10034754", "MSH:D011693", "SNOMEDCT_US:271813007", "SNOMEDCT_US:50091001", "UMLS:C0031256" ; oboInOwl:id "HP:0000967" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Petechiae" ; rdfs:subClassOf obo:HP_0031365 . obo:HP_0000968 obo:IAO_0000115 "Ectodermal dysplasia is a group of conditions in which there is abnormal development of the skin, hair, nails, teeth, or sweat glands." ; oboInOwl:hasAlternativeId "HP:0007615" ; oboInOwl:hasDbXref "MSH:D004476", "SNOMEDCT_US:254154003", "SNOMEDCT_US:8654005", "UMLS:C0013575" ; oboInOwl:id "HP:0000968" ; a owl:Class ; rdfs:comment "This term is kept in the HPO for now as 'ectodermal dysplasia' has been recorded as a phenotypic of other disorders such as DEAFNESS WITH ANHIDROTIC ECTODERMAL DYSPLASIA (MIM125050). Nevertheless it is preferable to use precise descriptions of the phenotypic abnormalities and this term should not be used for new annotations. It will be made obsolete in the future." ; rdfs:label "Ectodermal dysplasia" ; rdfs:subClassOf obo:HP_0011354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000924 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000969 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." ; oboInOwl:hasAlternativeId "HP:0000990" ; oboInOwl:hasDbXref "MSH:D004487", "SNOMEDCT_US:20741006", "SNOMEDCT_US:267038008", "SNOMEDCT_US:423666004", "SNOMEDCT_US:79654002", "UMLS:C0013604" ; oboInOwl:hasExactSynonym "Dropsy", "Fluid retention", "Hydrops", "Oedema", "Water retention" ; oboInOwl:id "HP:0000969" ; a owl:Class ; rdfs:comment "Edema may be related to one or more of the following factors: 1) increased capillary hydrostatic pressure, 2) decreased osmotic pressure of plasma, 3) decreased tissue tension and lymphatic drainage, 4) increased osmotic pressure of tissue fluids, and 5) increased capillary permeability." ; rdfs:label "Edema" ; rdfs:subClassOf obo:HP_0011032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000970 obo:IAO_0000115 "Inability to sweat." ; oboInOwl:hasDbXref "MEDDRA:10002512", "MSH:D007007", "SNOMEDCT_US:14662005", "SNOMEDCT_US:39659002", "UMLS:C0003028" ; oboInOwl:hasExactSynonym "Anhydrosis", "Lack of sweating", "Sudomotor dysfunction", "Sweating dysfunction" ; oboInOwl:id "HP:0000970" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anhidrosis" ; rdfs:subClassOf obo:HP_0025276 . obo:HP_0000971 obo:IAO_0000115 "Any structural abnormality of the sweat gland." ; oboInOwl:hasDbXref "MSH:D013543", "SNOMEDCT_US:88232005", "UMLS:C0038986", "UMLS:C0262643", "UMLS:C4020881" ; oboInOwl:hasExactSynonym "Abnormality of the sweat gland" ; oboInOwl:hasRelatedSynonym "Abnormalities of sweating", "Sweat gland disease" ; oboInOwl:id "HP:0000971" ; a owl:Class ; rdfs:label "Abnormal sweat gland morphology" ; rdfs:subClassOf obo:HP_0011138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000972 obo:IAO_0000115 "Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot." ; oboInOwl:hasAlternativeId "HP:0007548" ; oboInOwl:hasDbXref "MSH:D007645", "SNOMEDCT_US:706885006", "UMLS:C0022596" ; oboInOwl:hasExactSynonym "Hyperkeratosis of palms and soles", "Hyperkeratosis of the palms and soles", "Palmoplantar keratoses", "Palmoplantar keratosis", "Thick palms and soles", "Thickened palms and soles", "Thickening of the outer layer of the skin of the palms and soles" ; oboInOwl:id "HP:0000972" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature." ; rdfs:label "Palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0007556, obo:HP_0010765 . obo:HP_0000973 obo:IAO_0000115 "Wrinkled, redundant, inelastic and sagging skin." ; oboInOwl:hasBroadSynonym "Hanging skin" ; oboInOwl:hasDbXref "MSH:C531660", "MSH:D003483", "SNOMEDCT_US:58588007", "UMLS:C0010495", "UMLS:C2930812", "UMLS:C4280606" ; oboInOwl:hasExactSynonym "Chalazoderma", "Cutaneous laxity", "Dermatochalasia", "Dermatomegaly", "Elastolysis", "Generalised elastolysis", "Generalized elastolysis", "Hypoelastic skin", "Inelastic skin", "Lax skin", "Loose and inelastic skin", "Loose skin", "Skin laxity" ; oboInOwl:id "HP:0000973" ; a owl:Class ; rdfs:label "Cutis laxa" ; rdfs:subClassOf obo:HP_0008067 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001802 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000974 obo:IAO_0000115 "A condition in which the skin can be stretched beyond normal, and then returns to its initial position." ; oboInOwl:hasAlternativeId "HP:0007389", "HP:0007493", "HP:0007578" ; oboInOwl:hasDbXref "UMLS:C0241074" ; oboInOwl:hasExactSynonym "Hyperelastic skin", "Skin hyperelasticity", "Skin hyperextensibility", "Stretchable skin" ; oboInOwl:id "HP:0000974" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Skin hyperelasticity is to be distinguished from cutis laxa, which refers to extra, redundant skin which tends to hang in folds." ; rdfs:label "Hyperextensible skin" ; rdfs:subClassOf obo:HP_0008067 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002287 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000975 obo:IAO_0000115 "Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather." ; oboInOwl:hasAlternativeId "HP:0001011", "HP:0001064", "HP:0007424" ; oboInOwl:hasDbXref "MEDDRA:10020642", "MSH:D006945", "MSH:D013546", "SNOMEDCT_US:161857006", "SNOMEDCT_US:312230002", "SNOMEDCT_US:364538006", "SNOMEDCT_US:415690000", "SNOMEDCT_US:415691001", "SNOMEDCT_US:52613005", "UMLS:C0020458", "UMLS:C0038990", "UMLS:C0700590" ; oboInOwl:hasExactSynonym "Diaphoresis", "Excessive sweating", "Increased sweating", "Profuse sweating", "Sweating", "Sweating profusely", "Sweating, increased" ; oboInOwl:id "HP:0000975" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The terms hyperhidrosis and diaphoresis are often used interchangeably to describe excessive perspiration. Diaphoresis can be used to refer to excessive sweating that occurs with certain diseases (secondary hyperhidrosis). Since the HPO does not intend to provide coess for etiologies or diseases, we will use these terms interchangeably to refer to excessive perspiration without an appropriate cause such as hot and humid weather." ; rdfs:label "Hyperhidrosis" ; rdfs:subClassOf obo:HP_0007550 . obo:HP_0000976 oboInOwl:hasDbXref "MSH:D004485", "SNOMEDCT_US:281104002", "SNOMEDCT_US:43116000", "UMLS:C0013595" ; oboInOwl:id "HP:0000976" ; a owl:Class ; rdfs:label "Eczematoid dermatitis" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0000977 obo:IAO_0000115 "Subjective impression of increased softness upon palpation of the skin." ; oboInOwl:hasDbXref "UMLS:C0241178", "UMLS:C1844592" ; oboInOwl:hasExactSynonym "Soft skin" ; oboInOwl:hasRelatedSynonym "Velvety skin", "Velvety skin texture" ; oboInOwl:id "HP:0000977" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Soft skin" ; rdfs:subClassOf obo:HP_0010647 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000387 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000978 obo:IAO_0000115 "An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma." ; oboInOwl:hasAlternativeId "HP:0000959", "HP:0007433", "HP:0007472" ; oboInOwl:hasDbXref "MSH:D004438", "SNOMEDCT_US:302227002", "SNOMEDCT_US:424131007", "SNOMEDCT_US:425075004", "SNOMEDCT_US:77643000", "UMLS:C0013491", "UMLS:C0423798" ; oboInOwl:hasExactSynonym "Bruisability", "Bruise easily", "Bruising susceptibility", "Easy bruisability", "Easy bruising" ; oboInOwl:id "HP:0000978" ; a owl:Class ; rdfs:comment "An ecchymosis is defined as being larger than 1 cm in size." ; rdfs:label "Bruising susceptibility" ; rdfs:subClassOf obo:HP_0001933 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000979 obo:IAO_0000115 "Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae." ; oboInOwl:hasBroadSynonym "Blood spots" ; oboInOwl:hasDbXref "MSH:D011693", "SNOMEDCT_US:12393003", "SNOMEDCT_US:387778001", "SNOMEDCT_US:423902002", "UMLS:C0034150" ; oboInOwl:hasExactSynonym "Red or purple spots on the skin" ; oboInOwl:id "HP:0000979" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Depending on their size, purpuric lesions are traditionally classified as petechiae (pinpoint hemorrhages less than 2 mm in greatest diameter), purpura (2 mm to 1 cm) or ecchymoses (more than 1 cm)." ; rdfs:label "Purpura" ; rdfs:subClassOf obo:HP_0001933 . obo:HP_0000980 obo:IAO_0000115 "Abnormally pale skin." ; oboInOwl:hasDbXref "MSH:D010167", "SNOMEDCT_US:398979000", "UMLS:C0030232" ; oboInOwl:hasRelatedSynonym "Paleness", "Skin paleness" ; oboInOwl:id "HP:0000980" ; a owl:Class ; rdfs:label "Pallor" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000328 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000982 obo:IAO_0000115 "Abnormal thickening of the skin of the palms of the hands and the soles of the feet." ; oboInOwl:hasDbXref "MSH:D007645", "SNOMEDCT_US:706885006", "UMLS:C0022596" ; oboInOwl:hasExactSynonym "Palmar and plantar keratoderma", "Thickening of palms and soles" ; oboInOwl:id "HP:0000982" ; a owl:Class ; rdfs:label "Palmoplantar keratoderma" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0000987 obo:IAO_0000115 "Atypically scarred skin ." ; oboInOwl:hasDbXref "UMLS:C4021786" ; oboInOwl:hasExactSynonym "Atypical scarring", "Atypical scarring of skin" ; oboInOwl:id "HP:0000987" ; a owl:Class ; rdfs:label "Atypical scarring of skin" ; rdfs:subClassOf obo:HP_0011355, obo:HP_0100699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001850 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000988 obo:IAO_0000115 "A red eruption of the skin." ; oboInOwl:hasBroadSynonym "Rash" ; oboInOwl:hasDbXref "MEDDRA:10037844", "MSH:D005076", "SNOMEDCT_US:112625008", "SNOMEDCT_US:271807003", "UMLS:C0015230" ; oboInOwl:hasExactSynonym "Skin rash" ; oboInOwl:id "HP:0000988" ; a owl:Class ; rdfs:label "Skin rash" ; rdfs:subClassOf obo:HP_0011123 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040048 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000989 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." ; oboInOwl:hasDbXref "MSH:D011537", "SNOMEDCT_US:279333002", "SNOMEDCT_US:418290006", "SNOMEDCT_US:418363000", "SNOMEDCT_US:424492005", "UMLS:C0033774" ; oboInOwl:hasExactSynonym "Itching", "Itchy skin", "Skin itching" ; oboInOwl:id "HP:0000989" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pruritus" ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0000991 obo:IAO_0000115 "The presence of multiple xanthomas (xanthomata) in the skin. Xanthomas are yellowish, firm, lipid-laden nodules in the skin." ; oboInOwl:hasDbXref "MSH:D014973", "SNOMEDCT_US:63103006", "UMLS:C0043325" ; oboInOwl:hasExactSynonym "Xanthomata", "Yellow bumps of fatty deposits on skin" ; oboInOwl:id "HP:0000991" ; a owl:Class ; rdfs:label "Xanthomatosis" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0000992 obo:IAO_0000115 "An increased sensitivity of the skin to light. Photosensitivity may result in a rash upon exposure to the sun (which is known as photodermatosis). Photosensitivity can be diagnosed by phototests in which light is shone on small areas of skin." ; oboInOwl:hasAlternativeId "HP:0005594", "HP:0006831", "HP:0007538" ; oboInOwl:hasDbXref "MSH:D010787", "SNOMEDCT_US:90128006", "UMLS:C0349506" ; oboInOwl:hasExactSynonym "Photosensitive skin", "Photosensitive skin rashes", "Photosensitivity", "Sensitivity to sunlight", "Skin photosensitivity", "Sun sensitivity" ; oboInOwl:id "HP:0000992" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cutaneous photosensitivity" ; rdfs:subClassOf obo:HP_0011354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000547 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000993 obo:IAO_0000115 "Bluish-grey, spongy nodules associated with scars over pressure points and easily traumatized areas like the elbows and knees." ; oboInOwl:hasDbXref "UMLS:C1844597" ; oboInOwl:hasExactSynonym "Molluscoid pseudotumor" ; oboInOwl:id "HP:0000993" ; a owl:Class ; rdfs:label "Molluscoid pseudotumors" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0000995 obo:IAO_0000115 "A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger." ; oboInOwl:hasBroadSynonym "Noncancerous mole" ; oboInOwl:hasDbXref "MSH:D009508", "SNOMEDCT_US:21119008", "SNOMEDCT_US:400096001", "UMLS:C0027962", "UMLS:C4280269" ; oboInOwl:hasExactSynonym "Beauty mark", "Melanocytic naevus", "Melanocytic nevi", "Nevocellular nevi", "Pigmented naevi", "Pigmented nevi" ; oboInOwl:id "HP:0000995" ; a owl:Class ; rdfs:comment "Melanocytic nevi are commonly known as moles. The majority of moles appear during the first 20 to 30 years of a person's life, however, some may be present when the baby is born. The average human has from 10 to 14 moles. Moles can develop on the scalp, under the nails, armpits, virtually anywhere on the body. The total number of moles a person can have usually varies during his or her lifetime." ; rdfs:label "Melanocytic nevus" ; rdfs:subClassOf obo:HP_0001000, obo:HP_0003764 . obo:HP_0000996 obo:IAO_0000115 "Hemangioma, a benign tumor of the vascular endothelial cells with small endothelial spaces, occurring in the face." ; oboInOwl:hasDbXref "UMLS:C1858545" ; oboInOwl:id "HP:0000996" ; a owl:Class ; rdfs:label "Facial capillary hemangioma" ; rdfs:subClassOf obo:HP_0000329, obo:HP_0005306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000329 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000997 obo:IAO_0000115 "The presence in the axillary region (armpit) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin." ; oboInOwl:hasDbXref "UMLS:C1860335" ; oboInOwl:id "HP:0000997" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Axillary freckling" ; rdfs:subClassOf obo:HP_0001480 . obo:HP_0000998 obo:IAO_0000115 "Hypertrichosis is increased hair growth that is abnormal in quantity or location." ; oboInOwl:hasBroadSynonym "Excessive hair growth", "Increased hair growth on body" ; oboInOwl:hasDbXref "MSH:D006983", "SNOMEDCT_US:271607001", "SNOMEDCT_US:29966009", "UMLS:C0020555" ; oboInOwl:id "HP:0000998" ; a owl:Class ; rdfs:label "Hypertrichosis" ; rdfs:subClassOf obo:HP_0011362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0000999 obo:IAO_0000115 "Any manifestation of a skin disease associated with the production of pus." ; oboInOwl:hasDbXref "MSH:D011711", "SNOMEDCT_US:70759006", "UMLS:C0034212" ; oboInOwl:hasExactSynonym "Pus-filled lesion" ; oboInOwl:id "HP:0000999" ; a owl:Class ; rdfs:comment "Pyoderma is mainly seen with bacterial skin infections but can also be observed in autoimmune conditions." ; rdfs:label "Pyoderma" ; rdfs:subClassOf obo:HP_0005406 . obo:HP_0001000 obo:IAO_0000115 "An abnormality of the pigmentation of the skin." ; oboInOwl:hasAlternativeId "HP:0007582", "HP:0200045" ; oboInOwl:hasDbXref "UMLS:C1260926" ; oboInOwl:hasExactSynonym "Abnormal pigmentation", "Abnormal skin color", "Abnormal skin colour", "Abnormal skin pigmentation", "Abnormality of pigmentation", "Abnormality of skin pigmentation", "Pigmentary changes", "Pigmentary skin changes", "Pigmentation anomaly" ; oboInOwl:id "HP:0001000" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of skin pigmentation" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000014 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001001 oboInOwl:hasDbXref "UMLS:C4025813" ; oboInOwl:hasExactSynonym "Abnormality of fatty tissue below the skin" ; oboInOwl:id "HP:0001001" ; a owl:Class ; rdfs:label "Abnormality of subcutaneous fat tissue" ; rdfs:subClassOf obo:HP_0009124, obo:HP_0011354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002190 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001002 obo:IAO_0100001 "HP:0003758" ; oboInOwl:id "HP:0001002" ; a owl:Class ; rdfs:label "obsolete Decreased subcutaneous fat" ; owl:deprecated true . obo:HP_0001003 obo:IAO_0000115 "Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots." ; oboInOwl:hasDbXref "SNOMEDCT_US:72100002", "UMLS:C0036651", "UMLS:C1328931" ; oboInOwl:hasNarrowSynonym "Liver spots" ; oboInOwl:id "HP:0001003" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Lentigines are commonly (but not always) due to chronic sun exposure (solar lentigines; sometimes called liver spots) and occur most frequently on the face and back of the hands." ; rdfs:label "Multiple lentigines" ; rdfs:subClassOf obo:HP_0001034 . obo:HP_0001004 obo:IAO_0000115 "Localized fluid retention and tissue swelling caused by a compromised lymphatic system." ; oboInOwl:hasAlternativeId "HP:0003605" ; oboInOwl:hasDbXref "MSH:D008209", "SNOMEDCT_US:234097001", "SNOMEDCT_US:30213001", "UMLS:C0024236", "UMLS:C0240278", "UMLS:C1835229" ; oboInOwl:hasExactSynonym "Lymphatic obstruction", "Lymphoedema", "Onset of lymphedema around puberty", "Swelling caused by excess lymph fluid under skin" ; oboInOwl:id "HP:0001004" ; a owl:Class ; rdfs:label "Lymphedema" ; rdfs:subClassOf obo:HP_0000969 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006558 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001005 oboInOwl:hasDbXref "UMLS:C4025812" ; oboInOwl:id "HP:0001005" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Dermatological manifestations of systemic disorders" ; rdfs:subClassOf obo:HP_0011354 . obo:HP_0001006 obo:IAO_0100001 "HP:0008070" ; oboInOwl:id "HP:0001006" ; a owl:Class ; rdfs:label "obsolete Hypotrichosis" ; owl:deprecated true . obo:HP_0001007 obo:IAO_0000115 "Abnormally increased hair growth referring to a male pattern of body hair (androgenic hair)." ; oboInOwl:hasDbXref "MSH:D006628", "SNOMEDCT_US:399939002", "UMLS:C0019572" ; oboInOwl:hasExactSynonym "Excessive hairiness" ; oboInOwl:id "HP:0001007" ; a owl:Class ; rdfs:label "Hirsutism" ; rdfs:subClassOf obo:HP_0011362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001008 oboInOwl:hasDbXref "UMLS:C1843389" ; oboInOwl:id "HP:0001008" ; a owl:Class ; rdfs:label "Accumulation of melanosomes in melanocytes" ; rdfs:subClassOf obo:HP_0011125 . obo:HP_0001009 obo:IAO_0000115 "Telangiectasias refer to small dilated blood vessels located near the surface of the skin or mucous membranes, measuring between 0.5 and 1 millimeter in diameter. Telangiectasia are located especially on the tongue, lips, palate, fingers, face, conjunctiva, trunk, nail beds, and fingertips." ; oboInOwl:hasAlternativeId "HP:0001079" ; oboInOwl:hasDbXref "MSH:D013684", "SNOMEDCT_US:112641009", "SNOMEDCT_US:247479008", "UMLS:C0039446", "UMLS:C1138421" ; oboInOwl:hasExactSynonym "Telangiectases" ; oboInOwl:hasRelatedSynonym "Spider veins" ; oboInOwl:id "HP:0001009" ; a owl:Class ; rdfs:label "Telangiectasia" ; rdfs:subClassOf obo:HP_0011276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001010 obo:IAO_0000115 "A reduction of skin color related to a decrease in melanin production and deposition." ; oboInOwl:hasAlternativeId "HP:0005589", "HP:0007604", "HP:0007622" ; oboInOwl:hasDbXref "MSH:D017496", "SNOMEDCT_US:18655006", "SNOMEDCT_US:201284005", "SNOMEDCT_US:23006000", "SNOMEDCT_US:89031001", "UMLS:C0162835" ; oboInOwl:hasExactSynonym "Hypopigmentation", "Hypopigmented skin", "Patchy lightened skin" ; oboInOwl:hasRelatedSynonym "Skin hypopigmentation" ; oboInOwl:id "HP:0001010" ; a owl:Class ; rdfs:label "Hypopigmentation of the skin" ; rdfs:subClassOf obo:HP_0001000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001011 obo:IAO_0100001 "HP:0000975" ; oboInOwl:id "HP:0001011" ; a owl:Class ; rdfs:label "obsolete Diaphoresis (with pheochromocytoma)" ; owl:deprecated true . obo:HP_0001012 obo:IAO_0000115 "The presence of multiple lipomas (a type of benign tissue made of fatty tissue)." ; oboInOwl:hasDbXref "MSH:D008067", "NCIT:C3192", "SNOMEDCT_US:404062002", "SNOMEDCT_US:46720004", "SNOMEDCT_US:93163002", "UMLS:C0023798", "UMLS:C0745730" ; oboInOwl:hasExactSynonym "Multiple fatty lumps" ; oboInOwl:hasRelatedSynonym "Lipomas", "Lipomatosis" ; oboInOwl:id "HP:0001012" ; a owl:Class ; rdfs:comment "A lipoma is a benign tumor composed of fatty tissue. They are the most common form of soft tissue tumor and are usually soft to the touch, movable, and generally painless (but there is a separate entity of painful multiple lipomas which is a hereditary disease called Dercum disease or adiposis dolorosa). Many lipomas are small (under one centimeter diameter) but can enlarge to sizes greater than six centimeters. Lipomas are commonly found in adults from 40 to 60 years of age, but can also be found in children." ; rdfs:label "Multiple lipomas" ; rdfs:subClassOf obo:HP_0012031 . obo:HP_0001013 obo:IAO_0000115 "Eruptive xanthomas are yellow-orange-to-red-brown papules that are often surrounded by an erythematous halo. They appear in crops on the buttocks, extensor surfaces of the extremities, and flexural creases. Acutely, variable amounts of pruritus and pain occur." ; oboInOwl:hasDbXref "SNOMEDCT_US:238952003", "UMLS:C0221252" ; oboInOwl:id "HP:0001013" ; a owl:Class ; rdfs:comment "Eruptive xanthomas occur in the setting of chylomicronemia and hypertriglyceridemia." ; rdfs:label "Eruptive xanthomas" ; rdfs:subClassOf obo:HP_0000991 . obo:HP_0001014 obo:IAO_0000115 "Angiokeratomas are hyperkeratotic papules that are characterized histologically by superficial ectatic (i.e., dilated) blood vessels with epidermal proliferation. Clinically, angiokeratoma presents as a small, raised, dark-red spot." ; oboInOwl:hasDbXref "MSH:D000794", "SNOMEDCT_US:26810009", "UMLS:C0002985" ; oboInOwl:hasExactSynonym "Angiokeratomas" ; oboInOwl:id "HP:0001014" ; a owl:Class ; rdfs:comment "Angiokeratomas occur clinically as 1 of 5 different subtypes." ; rdfs:label "Angiokeratoma" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0001015 obo:IAO_0000115 "A condition in which superficial veins (i.e., veins just under the skin) are more conspicuous or noticable than normal." ; oboInOwl:hasDbXref "UMLS:C1837785" ; oboInOwl:hasExactSynonym "Marked subcutaneous veins", "Prominent veins" ; oboInOwl:id "HP:0001015" ; a owl:Class ; rdfs:comment "See Figure 4 of PMID:24456199" ; rdfs:label "Prominent superficial veins" ; rdfs:subClassOf obo:HP_0002624, obo:HP_0007394 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035550 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001017 obo:IAO_0000115 "A type of pallor that is secondary to the presence of anemia." ; oboInOwl:hasDbXref "UMLS:C4025811" ; oboInOwl:hasExactSynonym "Anaemic pallor" ; oboInOwl:id "HP:0001017" ; a owl:Class ; rdfs:label "Anemic pallor" ; rdfs:subClassOf obo:HP_0000980 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000980 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001903 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001018 obo:IAO_0000115 "An abnormality of the dermatoglyphs, i.e., an abnormality of the patterns of ridges of the skin of palm of hand." ; oboInOwl:hasDbXref "UMLS:C4025810" ; oboInOwl:id "HP:0001018" ; a owl:Class ; rdfs:label "Abnormal palmar dermatoglyphics" ; rdfs:subClassOf obo:HP_0007477, obo:HP_0040211 . obo:HP_0001019 obo:IAO_0000115 "An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever." ; oboInOwl:hasBroadSynonym "Red scaly skin caused by inflammatory skin disease" ; oboInOwl:hasDbXref "MSH:D003873", "SNOMEDCT_US:200948000", "SNOMEDCT_US:396349005", "SNOMEDCT_US:396350005", "SNOMEDCT_US:399992009", "SNOMEDCT_US:400005007", "UMLS:C0011606" ; oboInOwl:hasExactSynonym "Exfoliative dermititis", "Generalised erythroderma", "Generalised erythrodermia", "Generalized erythroderma", "Generalized erythrodermia" ; oboInOwl:id "HP:0001019" ; a owl:Class ; rdfs:label "Erythroderma" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0001022 obo:IAO_0000115 "An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina)." ; oboInOwl:hasDbXref "MSH:D000417", "SNOMEDCT_US:15890002", "SNOMEDCT_US:18064000", "UMLS:C0001916", "UMLS:C0333913" ; oboInOwl:hasExactSynonym "Achromasia", "Albinism" ; oboInOwl:id "HP:0001022" ; a owl:Class ; rdfs:label "Albinism" ; rdfs:subClassOf obo:HP_0005599, obo:HP_0007513 . obo:HP_0001024 oboInOwl:hasDbXref "UMLS:C1855815" ; oboInOwl:id "HP:0001024" ; a owl:Class ; rdfs:label "Skin dimple over apex of long bone angulation" ; rdfs:subClassOf obo:HP_0010781 . obo:HP_0001025 obo:IAO_0000115 "Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure." ; oboInOwl:hasDbXref "MEDDRA:10046735", "MSH:D014581", "SNOMEDCT_US:126485001", "SNOMEDCT_US:247472004", "SNOMEDCT_US:64305001", "UMLS:C0042109" ; oboInOwl:hasExactSynonym "Hives" ; oboInOwl:id "HP:0001025" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Urticaria" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0001026 oboInOwl:hasDbXref "UMLS:C4025809" ; oboInOwl:hasExactSynonym "Penetrating foot ulcers" ; oboInOwl:id "HP:0001026" ; a owl:Class ; rdfs:label "Penetrating foot ulcers" ; rdfs:subClassOf obo:HP_0200042 . obo:HP_0001027 obo:IAO_0000115 "A skin texture that is unusually soft (and may feel silky), and has a malleable consistency resembling that of dough." ; oboInOwl:hasDbXref "UMLS:C1849043" ; oboInOwl:hasExactSynonym "Soft, doughy skin" ; oboInOwl:id "HP:0001027" ; a owl:Class ; rdfs:label "Soft, doughy skin" ; rdfs:subClassOf obo:HP_0000977 . obo:HP_0001028 obo:IAO_0000115 "A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma)." ; oboInOwl:hasAlternativeId "HP:0007444" ; oboInOwl:hasDbXref "MSH:D006391", "NCIT:C3085", "SNOMEDCT_US:2099007", "SNOMEDCT_US:253053003", "SNOMEDCT_US:400210000", "UMLS:C0018916" ; oboInOwl:hasExactSynonym "Strawberry mark" ; oboInOwl:hasRelatedSynonym "Hemangiomata" ; oboInOwl:id "HP:0001028" ; a owl:Class ; rdfs:label "Hemangioma" ; rdfs:subClassOf obo:HP_0100742 . obo:HP_0001029 obo:IAO_0000115 "Poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias." ; oboInOwl:hasDbXref "MEDDRA:10057041", "SNOMEDCT_US:402685001", "SNOMEDCT_US:70114006", "UMLS:C0392777" ; oboInOwl:id "HP:0001029" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Poikiloderma does not refer to a specific disease entity, but can be seen owing to a number of different causes. See Figure 2 of PMID:32363096." ; rdfs:label "Poikiloderma" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0001030 obo:IAO_0000115 "Skin that splits easily with minimal injury." ; oboInOwl:hasDbXref "MEDDRA:10040851", "SNOMEDCT_US:247427007", "UMLS:C0241181" ; oboInOwl:hasExactSynonym "Fragile skin", "Skin fragility" ; oboInOwl:id "HP:0001030" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fragile skin" ; rdfs:subClassOf obo:HP_0011354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001362 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001031 obo:IAO_0000115 "The presence of subcutaneous lipoma." ; oboInOwl:hasDbXref "NCIT:C3192", "UMLS:C1403035" ; oboInOwl:id "HP:0001031" ; a owl:Class ; rdfs:label "Subcutaneous lipoma" ; rdfs:subClassOf obo:HP_0001001, obo:HP_0001012, obo:HP_0008069 . obo:HP_0001032 obo:IAO_0000115 "Absence of the distal interphalangeal flexion creases of the fingers." ; oboInOwl:hasDbXref "UMLS:C1861349" ; oboInOwl:hasExactSynonym "Absence of skin creases over distal interphalangeal joints", "Aplasia of the distal interphalangeal creases", "Distal finger flexion creases absent" ; oboInOwl:id "HP:0001032" ; a owl:Class ; rdfs:label "Absent distal interphalangeal creases" ; rdfs:subClassOf obo:HP_0006109 . obo:HP_0001033 oboInOwl:hasDbXref "UMLS:C4025808" ; oboInOwl:hasExactSynonym "Facial flushing after alcohol intake" ; oboInOwl:id "HP:0001033" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Facial flushing after alcohol intake" ; rdfs:subClassOf obo:HP_0031284 . obo:HP_0001034 obo:IAO_0000115 "A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size." ; oboInOwl:hasAlternativeId "HP:0007442", "HP:0007491", "HP:0007492", "HP:0100815", "HP:0200031", "HP:0200033" ; oboInOwl:hasDbXref "UMLS:C1842774" ; oboInOwl:hasExactSynonym "Hyperpigmented macules", "Hyperpigmented spots" ; oboInOwl:hasRelatedSynonym "Hyperpigmented skin patches" ; oboInOwl:id "HP:0001034" ; a owl:Class ; rdfs:label "Hypermelanotic macule" ; rdfs:subClassOf obo:HP_0007400, obo:HP_0012733 . obo:HP_0001036 obo:IAO_0000115 "Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes." ; oboInOwl:hasDbXref "MSH:D010241", "SNOMEDCT_US:200766001", "SNOMEDCT_US:65068000", "UMLS:C0030436" ; oboInOwl:id "HP:0001036" ; a owl:Class ; rdfs:comment "Persistence of the nuclei of keratinocytes as they rise into the stratum corneum of the epidermis. Parakeratosis is observed as scaling in many conditions such as psoriasis." ; rdfs:label "Parakeratosis" ; rdfs:subClassOf obo:HP_0011368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_156 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006915 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001038 oboInOwl:hasDbXref "UMLS:C1867638" ; oboInOwl:id "HP:0001038" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Warfarin-induced skin necrosis" ; rdfs:subClassOf obo:HP_0001005 . obo:HP_0001039 oboInOwl:hasDbXref "UMLS:C4025807" ; oboInOwl:id "HP:0001039" ; a owl:Class ; rdfs:label "Atheroeruptive xanthoma" ; rdfs:subClassOf obo:HP_0000991 . obo:HP_0001040 oboInOwl:hasDbXref "UMLS:C1867448" ; oboInOwl:id "HP:0001040" ; a owl:Class ; rdfs:label "Multiple pterygia" ; rdfs:subClassOf obo:HP_0001059 . obo:HP_0001041 obo:IAO_0000115 "Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin." ; oboInOwl:hasAlternativeId "HP:0001068" ; oboInOwl:hasDbXref "MSH:D001821", "MSH:D012393", "SNOMEDCT_US:20255002", "SNOMEDCT_US:271811009", "SNOMEDCT_US:398909004", "UMLS:C0005874", "UMLS:C0035854", "UMLS:C0239488", "UMLS:C4020880" ; oboInOwl:hasExactSynonym "Blushed cheeks", "Blushing", "Red face", "Red in the face" ; oboInOwl:hasNarrowSynonym "Rosacea" ; oboInOwl:hasRelatedSynonym "Ruddy face" ; oboInOwl:id "HP:0001041" ; a owl:Class ; rdfs:label "Facial erythema" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0001042 oboInOwl:hasDbXref "UMLS:C4025806" ; oboInOwl:id "HP:0001042" ; a owl:Class ; rdfs:label "High axial triradius" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0001043 oboInOwl:hasDbXref "UMLS:C1856542" ; oboInOwl:hasExactSynonym "Prominent scalp veins" ; oboInOwl:id "HP:0001043" ; a owl:Class ; rdfs:label "Prominent scalp veins" ; rdfs:subClassOf obo:HP_0001015, obo:HP_0001965, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001045 oboInOwl:hasDbXref "MSH:D014820", "SNOMEDCT_US:56727007", "UMLS:C0042900" ; oboInOwl:hasExactSynonym "Blotchy loss of skin color", "Blotchy loss of skin colour" ; oboInOwl:id "HP:0001045" ; a owl:Class ; rdfs:label "Vitiligo" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0001046 obo:IAO_0000115 "Jaundice that is sometimes present, sometimes not." ; oboInOwl:hasDbXref "UMLS:C4025805" ; oboInOwl:hasExactSynonym "Intermittent icterus", "Intermittent yellow skin", "Intermittent yellowing of skin" ; oboInOwl:id "HP:0001046" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Intermittent jaundice" ; rdfs:subClassOf obo:HP_0000952 . obo:HP_0001047 obo:IAO_0000115 "Atopic dermatitis (AD) or atopic eczema is an itchy, inflammatory skin condition with a predilection for the skin flexures. It is characterized by poorly defined erythema with edema, vesicles, and weeping in the acute stage and skin thickening (lichenification) in the chronic stage." ; oboInOwl:hasAlternativeId "HP:0007533", "HP:0007564" ; oboInOwl:hasDbXref "MSH:D003876", "SNOMEDCT_US:200775004", "SNOMEDCT_US:24079001", "UMLS:C0011615", "UMLS:C4280605" ; oboInOwl:hasExactSynonym "Atopic dermatitis, chronic", "Dermatitis, Atopic" ; oboInOwl:hasRelatedSynonym "Baby eczema" ; oboInOwl:id "HP:0001047" ; a owl:Class ; rdfs:comment "In infants, atopic dermatitis is known as infantile eczema." ; rdfs:label "Atopic dermatitis" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0001048 obo:IAO_0000115 "The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma." ; oboInOwl:hasDbXref "MEDDRA:10055899", "MSH:D006392", "NCIT:C3086", "SNOMEDCT_US:33377007", "SNOMEDCT_US:416824008", "SNOMEDCT_US:56975005", "UMLS:C0018920" ; oboInOwl:hasExactSynonym "Cavernous angioma", "Cavernous haemangioma", "Collection of dilated blood vessels that forms mass" ; oboInOwl:id "HP:0001048" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cavernous hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0001049 oboInOwl:hasDbXref "UMLS:C1861400" ; oboInOwl:id "HP:0001049" ; a owl:Class ; rdfs:label "Absent dorsal skin creases over affected joints" ; rdfs:subClassOf obo:HP_0006143 . obo:HP_0001050 oboInOwl:hasDbXref "SNOMEDCT_US:75246004", "UMLS:C0232370" ; oboInOwl:id "HP:0001050" ; a owl:Class ; rdfs:comment "Related to polycythemia." ; rdfs:label "Plethora" ; rdfs:subClassOf obo:HP_0001005 . obo:HP_0001051 obo:IAO_0000115 "Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk." ; oboInOwl:hasAlternativeId "HP:0007562" ; oboInOwl:hasDbXref "MSH:D012628", "SNOMEDCT_US:50563003", "SNOMEDCT_US:86708008", "UMLS:C0036508", "UMLS:C3806554" ; oboInOwl:hasExactSynonym "Seborrhea", "Seborrheic eczema" ; oboInOwl:hasRelatedSynonym "Dysseborrheic dermatitis" ; oboInOwl:id "HP:0001051" ; a owl:Class ; rdfs:comment "Dandruff." ; rdfs:label "Seborrheic dermatitis" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0001052 obo:IAO_0000115 "A congenital vascular malformation consisting of superficial and deep dilated capillaries in the skin which produce a reddish to purplish discolouration of the skin." ; oboInOwl:hasDbXref "MEDDRA:10067193", "MSH:D019339", "SNOMEDCT_US:254211001", "SNOMEDCT_US:416377005", "UMLS:C0235752" ; oboInOwl:hasExactSynonym "Nevus simplex", "port-wine stain" ; oboInOwl:id "HP:0001052" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Port-wine stains generally become deeper, thicker, and darker in color over time, mainly as a result of progressive vascular dilatation. As a result of these changes, which are generally much more evident on the face, patients often develop hypertrophy and nodularity after the third or fourth decade of life. The fact that nodules are only found on the face and do not occur in childhood has led some authors to suggest that port-wine stains might actually be hamartomatous lesions." ; rdfs:label "Nevus flammeus" ; rdfs:subClassOf obo:HP_0003764, obo:HP_0025104 . obo:HP_0001053 oboInOwl:hasDbXref "UMLS:C1836735" ; oboInOwl:hasExactSynonym "Patchy loss of skin color", "Patchy loss of skin colour" ; oboInOwl:id "HP:0001053" ; a owl:Class ; rdfs:label "Hypopigmented skin patches" ; rdfs:subClassOf obo:HP_0001010, obo:HP_0011355 . obo:HP_0001054 oboInOwl:hasDbXref "UMLS:C1849677" ; oboInOwl:hasExactSynonym "Multiple pigmented nevi", "Numerous moles" ; oboInOwl:id "HP:0001054" ; a owl:Class ; rdfs:label "Numerous nevi" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0001055 obo:IAO_0000115 "Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system." ; oboInOwl:hasDbXref "MEDDRA:10015145", "MSH:D004881", "MSH:D004886", "SNOMEDCT_US:44653001", "SNOMEDCT_US:51510002", "UMLS:C0014714", "UMLS:C0014733" ; oboInOwl:hasRelatedSynonym "St. Anthony's Fire" ; oboInOwl:id "HP:0001055" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Erysipelas" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0001056 obo:IAO_0000115 "Presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin." ; oboInOwl:hasDbXref "SNOMEDCT_US:254679001", "SNOMEDCT_US:254683001", "SNOMEDCT_US:37719003", "UMLS:C0345996" ; oboInOwl:hasExactSynonym "Milk spot", "Millium cyst" ; oboInOwl:id "HP:0001056" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Milia are a normal finding in newborn babies (40-50%), often occurring around the nose." ; rdfs:label "Milia" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0001057 obo:IAO_0000115 "A developmental defect resulting in the congenital absence of skin in multiple or solitary non-inflammatory, well-demarcated, oval or circular ulcers with a diameter of about 1 to 2 cm. Aplasia cutis congenita most commonly occurs on the scalp, but may present in the face, trunk, or limbs." ; oboInOwl:hasBroadSynonym "Congenital scars" ; oboInOwl:hasDbXref "MEDDRA:10002963", "MSH:D004476", "SNOMEDCT_US:254237003", "SNOMEDCT_US:35484002", "SNOMEDCT_US:74223008", "UMLS:C0265989", "UMLS:C0282160" ; oboInOwl:hasExactSynonym "Absence of part of skin at birth", "Congenital absence of skin", "Cutis aplasia" ; oboInOwl:id "HP:0001057" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplasia cutis congenita" ; rdfs:subClassOf obo:HP_0008065 . obo:HP_0001058 obo:IAO_0000115 "A reduced ability to heal cutaneous wounds." ; oboInOwl:hasDbXref "UMLS:C1851789" ; oboInOwl:hasExactSynonym "Poor wound healing" ; oboInOwl:id "HP:0001058" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Poor wound healing" ; rdfs:subClassOf obo:HP_0011354 . obo:HP_0001059 obo:IAO_0000115 "Pterygia are 'winglike' triangular membranes occurring in the neck, eyes, knees, elbows, ankles or digits." ; oboInOwl:hasDbXref "MSH:D011625", "SNOMEDCT_US:77489003", "UMLS:C0033999" ; oboInOwl:hasRelatedSynonym "Pterygia" ; oboInOwl:id "HP:0001059" ; a owl:Class ; rdfs:label "Pterygium" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0011356 . obo:HP_0001060 obo:IAO_0000115 "Presence of a cutaneous membrane (flap) in the armpit." ; oboInOwl:hasDbXref "UMLS:C1844738" ; oboInOwl:hasExactSynonym "Axillary pterygia" ; oboInOwl:id "HP:0001060" ; a owl:Class ; rdfs:label "Axillary pterygium" ; rdfs:subClassOf obo:HP_0001059 . obo:HP_0001061 obo:IAO_0000115 "A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." ; oboInOwl:hasAlternativeId "HP:0005596" ; oboInOwl:hasBroadSynonym "Breaking out" ; oboInOwl:hasDbXref "MEDDRA:10000496", "SNOMEDCT_US:11381005", "UMLS:C0702166" ; oboInOwl:hasExactSynonym "Acne" ; oboInOwl:id "HP:0001061" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Acne can be a consequence of increased sebum production as a result of increased testosterone production (in males and females) during puberty. Blockage of hair follicles canresult from accumulating keratin and sebum, resulting in plug formation called microcomedone, which can enlarge just beneath the surface of the skin in the pore itself. It may become visible as a closed comedone (whitehead), a firm white papule. Further enlargement leads to an open comedone (blackhead). The comedones are not themselves inflammatory. Proprionibacterium acnes can induce inflammation, leding to an inflammed, red papule." ; rdfs:label "Acne" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0001062 obo:IAO_0000115 "A large pigmented lesion measuring 5-15 mm in diameter with irregular, notched, and ill defined border and with color that may range from tan to dark brown to pink." ; oboInOwl:hasDbXref "MSH:D004416", "SNOMEDCT_US:254818000", "SNOMEDCT_US:61814002", "UMLS:C0205748" ; oboInOwl:hasExactSynonym "Atypical mole" ; oboInOwl:hasRelatedSynonym "Dysplastic Nevus" ; oboInOwl:id "HP:0001062" ; a owl:Class ; rdfs:comment "Macular and papular areas may be present within a single lesion (also described as a fried egg appearance). The terms atypical moles and dysplastic nevi are used interchangeably, regardless of clinical or histologic appearance." ; rdfs:label "Atypical nevus" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0001063 obo:IAO_0000115 "Bluish discoloration of the skin of the hands or feet." ; oboInOwl:hasDbXref "SNOMEDCT_US:25003006", "UMLS:C0221347" ; oboInOwl:hasExactSynonym "Persistent blue color of hands or feet", "Persistent blue colour of hands or feet" ; oboInOwl:id "HP:0001063" ; a owl:Class ; rdfs:comment "Cyanosis is caused by increased levels of deoxygenated hemoglobin." ; rdfs:label "Acrocyanosis" ; rdfs:subClassOf obo:HP_0034033 . obo:HP_0001065 obo:IAO_0000115 "Thinned, erythematous, depressed bands of atrophic skin. Initially, striae appear as flattened and thinned, pinkish linear regions of the skin. Striae tend to enlarge in length and become reddish or purplish. Later, striae tend to appear as white, depressed bands that are parallel to the lines of skin tension. Striae distensae occur most often in areas that have been subject to distension such as the lower back, buttocks, thighs, breast, abdomen, and shoulders." ; oboInOwl:hasAlternativeId "HP:0001023", "HP:0001066", "HP:0100680" ; oboInOwl:hasDbXref "MEDDRA:10040925", "MSH:D057896", "SNOMEDCT_US:201066002", "SNOMEDCT_US:201067006", "SNOMEDCT_US:47212006", "UMLS:C0152459" ; oboInOwl:hasExactSynonym "Purplish striae", "Stretch marks", "Striae", "Striae atrophicae", "Striae cutis distensae" ; oboInOwl:id "HP:0001065" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Striae distensae" ; rdfs:subClassOf obo:HP_0004334, obo:HP_0100679 . obo:HP_0001067 obo:IAO_0000115 "A benign peripheral nerve sheath tumor that generally appears as a soft, skin-colored papule or small subcutaneous nodule. Individuals with neurofibromatosis can have numerous neurofibromas." ; oboInOwl:hasAlternativeId "HP:0006746", "HP:0007386", "HP:0007612" ; oboInOwl:hasDbXref "MSH:D017253", "NCIT:C3272", "SNOMEDCT_US:19133005", "SNOMEDCT_US:81669005", "UMLS:C0162678" ; oboInOwl:hasExactSynonym "Neurofibromata", "Neurofibromatosis" ; oboInOwl:hasRelatedSynonym "multiple neurofibromas" ; oboInOwl:id "HP:0001067" ; a owl:Class ; rdfs:label "Neurofibroma" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0010614, obo:HP_0100007 . obo:HP_0001069 obo:IAO_0000115 "Intermittent episodes of abnormally increased perspiration." ; oboInOwl:hasDbXref "UMLS:C1857171" ; oboInOwl:hasExactSynonym "Hyperhidrosis, episodic", "Sporadic excessive sweating" ; oboInOwl:id "HP:0001069" ; a owl:Class ; rdfs:label "Episodic hyperhidrosis" ; rdfs:subClassOf obo:HP_0000975 . obo:HP_0001070 obo:IAO_0000115 "Patchy and irregular skin pigmentation." ; oboInOwl:hasAlternativeId "HP:0007584" ; oboInOwl:hasDbXref "UMLS:C0860439", "UMLS:C4020879" ; oboInOwl:hasExactSynonym "Mottled skin coloring", "Mottled skin colouring" ; oboInOwl:hasRelatedSynonym "Stippled pigmentation" ; oboInOwl:id "HP:0001070" ; a owl:Class ; rdfs:label "Mottled pigmentation" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0001071 obo:IAO_0000115 "Angiokeratoma corporis diffusum (ACD) is typically characterized by innumerable small red to black papules which occur in clusters and are situated symmetrically in the bathing trunks area. The number of lesions and the extension of the body increase steadily with time so that generalization and mucosal involvement are common. The single lesion begins with a minute reddish papule which enlarges to up to 10 mm in diameter, becomes dark red to black with a discrete keratotic overgrowth. Histologically, the papules are characterized by superficial dilated capillaries in papillary dermis with epidermal proliferation." ; oboInOwl:hasDbXref "MSH:D000795", "SNOMEDCT_US:124464003", "SNOMEDCT_US:16652001", "UMLS:C0002986" ; oboInOwl:hasExactSynonym "Fabry syndrome" ; oboInOwl:id "HP:0001071" ; a owl:Class ; rdfs:comment "Angiokeratoma corporis diffusum (ACD) commonly occurs in Fabry disease and the term ACD was previously used synonymously with Fabry disease (OMIM:301500). However, ACD can also occur with other diseases related to deficiencies of enzymes that are involved in the metabolism of glycoproteins, including fucosidosis, sialidosis, mannosidosis, GM1 gangliosidosis, and Kanzaki disease." ; rdfs:label "Angiokeratoma corporis diffusum" ; rdfs:subClassOf obo:HP_0001014 . obo:HP_0001072 obo:IAO_0000115 "Laminar thickening of skin." ; oboInOwl:hasAlternativeId "HP:0007393" ; oboInOwl:hasDbXref "MEDDRA:10040936", "SNOMEDCT_US:17417006", "SNOMEDCT_US:69943009", "UMLS:C0334008", "UMLS:C4020878" ; oboInOwl:hasExactSynonym "Pachydermia", "Thick skin", "Thickened skin" ; oboInOwl:hasRelatedSynonym "Diffusely thickened skin" ; oboInOwl:id "HP:0001072" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thickened skin" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001073 obo:IAO_0000115 "Thin (atrophic) and wide scars." ; oboInOwl:hasDbXref "UMLS:C1851828" ; oboInOwl:hasExactSynonym "Cigarette paper scarring", "Cigarette-paper scars" ; oboInOwl:id "HP:0001073" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Cigarette-paper scars are atrophic scars in the skin at sites of minor lacerations over the knees, shins, and elbows." ; rdfs:label "Cigarette-paper scars" ; rdfs:subClassOf obo:HP_0001075 . obo:HP_0001074 oboInOwl:hasDbXref "UMLS:C4021837" ; oboInOwl:id "HP:0001074" ; a owl:Class ; rdfs:label "Atypical nevi in non-sun exposed areas" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0001075 obo:IAO_0000115 "Scars that form a depression compared to the level of the surrounding skin because of damage to the collagen, fat or other tissues below the skin." ; oboInOwl:hasAlternativeId "HP:0007567" ; oboInOwl:hasDbXref "SNOMEDCT_US:239172000", "SNOMEDCT_US:409766009", "UMLS:C0162154" ; oboInOwl:hasExactSynonym "Sunken or indented skin due to damage", "Thin, atrophic scars" ; oboInOwl:id "HP:0001075" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Atrophic scars" ; rdfs:subClassOf obo:HP_0000987, obo:HP_0004334 . obo:HP_0001076 oboInOwl:hasDbXref "UMLS:C1854408" ; oboInOwl:hasExactSynonym "Glabellar capillary hemangioma" ; oboInOwl:id "HP:0001076" ; a owl:Class ; rdfs:label "Glabellar hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0001080 obo:IAO_0000115 "An abnormality of the biliary tree." ; oboInOwl:hasDbXref "MSH:D001660", "SNOMEDCT_US:105997008", "UMLS:C0005424", "UMLS:C0549613" ; oboInOwl:hasRelatedSynonym "Biliary tract disease" ; oboInOwl:id "HP:0001080" ; a owl:Class ; rdfs:label "Biliary tract abnormality" ; rdfs:subClassOf obo:HP_0004297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001081 obo:IAO_0000115 "Hard, pebble-like deposits that form within the gallbladder." ; oboInOwl:hasDbXref "MSH:D002769", "SNOMEDCT_US:266474003", "UMLS:C0008350" ; oboInOwl:hasExactSynonym "Gallstones" ; oboInOwl:id "HP:0001081" ; a owl:Class ; rdfs:comment "Gallstones range in size from as small as a grain of sand to as large as a golf ball. Cholesterol gallstones are the most common type of gallstone. Gallstones resulting from too much bilirubin in the bile are referred to as pigment stones." ; rdfs:label "Cholelithiasis" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0001082 obo:IAO_0000115 "The presence of inflammatory changes in the gallbladder." ; oboInOwl:hasDbXref "MSH:D002764", "SNOMEDCT_US:76581006", "UMLS:C0008325" ; oboInOwl:hasExactSynonym "Gallbladder inflammation" ; oboInOwl:id "HP:0001082" ; a owl:Class ; rdfs:label "Cholecystitis" ; rdfs:subClassOf obo:HP_0012438 . obo:HP_0001083 obo:IAO_0000115 "Dislocation or malposition of the crystalline lens of the eye. A partial displacement (or dislocation) of the lens is described as a subluxation of the lens, while a complete displacement is termed luxation of the lens. A complete displacement occurs if the lens is completely outside the patellar fossa of the lens, either in the anterior chamber, in the vitreous, or directly on the retina. If the lens is partially displaced but still contained within the lens space, then it is termed subluxation." ; oboInOwl:hasAlternativeId "HP:0000665", "HP:0007637", "HP:0007882", "HP:0008016" ; oboInOwl:hasDbXref "MSH:D004479", "MSH:D007906", "SNOMEDCT_US:74969002", "UMLS:C0013581", "UMLS:C0023309" ; oboInOwl:hasExactSynonym "Abnormality of lens position", "Lens dislocation" ; oboInOwl:id "HP:0001083" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ectopia lentis" ; rdfs:subClassOf obo:HP_0000517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001084 obo:IAO_0000115 "A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years." ; oboInOwl:hasAlternativeId "HP:0100741" ; oboInOwl:hasDbXref "MSH:D001112", "SNOMEDCT_US:111522004", "SNOMEDCT_US:231924000", "SNOMEDCT_US:231925004", "UMLS:C0003742", "UMLS:C0339268" ; oboInOwl:hasExactSynonym "Anterior embryotoxon", "Arcus lipoidis", "Arcus senilis", "Corneal annulus", "Gerontoxon" ; oboInOwl:hasRelatedSynonym "Arcus juvenilis" ; oboInOwl:id "HP:0001084" ; a owl:Class ; rdfs:comment "A grey opaque line which surrounds the margin of the cornea caused by lipid deposits." ; rdfs:label "Corneal arcus" ; rdfs:subClassOf obo:HP_0008011 . obo:HP_0001085 obo:IAO_0000115 "Papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure." ; oboInOwl:hasAlternativeId "HP:0001130" ; oboInOwl:hasDbXref "MSH:D010211", "SNOMEDCT_US:248487006", "SNOMEDCT_US:423341008", "SNOMEDCT_US:73221001", "UMLS:C0030353" ; oboInOwl:hasRelatedSynonym "Papillitis" ; oboInOwl:id "HP:0001085" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The borders of the optic disc are normally clear and well defined upon fundoscopic examination. Papilledema is optic disc swelling that can lead to the blurring of optic margins and elevation of optic disc." ; rdfs:label "Papilledema" ; rdfs:subClassOf obo:HP_0012795 . obo:HP_0001087 obo:IAO_0000115 "Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma." ; oboInOwl:hasDbXref "MSH:D006871", "SNOMEDCT_US:204113001", "SNOMEDCT_US:413728006", "UMLS:C0020302" ; oboInOwl:hasExactSynonym "Childhood glaucoma", "Infantile glaucoma", "Paediatric glaucoma", "Pediatric glaucoma" ; oboInOwl:id "HP:0001087" ; a owl:Class ; rdfs:label "Developmental glaucoma" ; rdfs:subClassOf obo:HP_0000501, obo:HP_0007700 . obo:HP_0001088 obo:IAO_0000115 "The presence of whitish spots in a ring-like arrangement at the periphery of the iris." ; oboInOwl:hasDbXref "SNOMEDCT_US:400960002", "UMLS:C1303007", "UMLS:C4280604" ; oboInOwl:hasExactSynonym "Iris brushfield spots" ; oboInOwl:hasRelatedSynonym "Speckled iris" ; oboInOwl:id "HP:0001088" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Brushfield spots are relatively common in the general population but opccur more frequently in persons with certain disorders (especially Down syndrome)." ; rdfs:label "Brushfield spots" ; rdfs:subClassOf obo:HP_0008034 . obo:HP_0001089 obo:IAO_0000115 "Loss of iris tissue (atrophy)" ; oboInOwl:hasDbXref "SNOMEDCT_US:95709007", "UMLS:C0423319" ; oboInOwl:hasExactSynonym "Iris degeneration" ; oboInOwl:id "HP:0001089" ; a owl:Class ; rdfs:label "Iris atrophy" ; rdfs:subClassOf obo:HP_0000525 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001090 obo:IAO_0000115 "Diffusely large eye (with megalocornea) without glaucoma." ; oboInOwl:hasAlternativeId "HP:0200093" ; oboInOwl:hasDbXref "SNOMEDCT_US:246920008", "UMLS:C0423221", "UMLS:C1855852", "UMLS:C4280603" ; oboInOwl:hasExactSynonym "Increased size of eyes", "Large eyes", "Megalophthalmos" ; oboInOwl:hasRelatedSynonym "Increased size of palpebral fissures", "Large eyeballs", "Large of palpebral fissures" ; oboInOwl:id "HP:0001090" ; a owl:Class ; rdfs:comment "Note that Increased size of palpebral fissues is not a synonym of this term." ; rdfs:label "Abnormally large globe" ; rdfs:subClassOf obo:HP_0100887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001092 obo:IAO_0000115 "No identifiable superior and/or inferior lacrimal punctum." ; oboInOwl:hasAlternativeId "HP:0007977" ; oboInOwl:hasDbXref "MSH:C566703", "SNOMEDCT_US:204208005", "SNOMEDCT_US:253217007", "UMLS:C0344509", "UMLS:C1867060" ; oboInOwl:hasExactSynonym "Absent lacrimal gland puncta", "Absent lacrimal openings", "Absent lacrimal puncta", "Aplasia of lacrimal puncta", "Lacrimal puncta aplasia", "Lacrimal punctum, absence" ; oboInOwl:hasRelatedSynonym "Agenesis of the lacrimal punctum" ; oboInOwl:id "HP:0001092" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The lacrimal puncta (openings of the tear ducts) are normally located at the medial margin of each eyelid. The opening on the lower eyelid border is more visible than the opening on the upper eyelid border." ; rdfs:label "Absent lacrimal punctum" ; rdfs:subClassOf obo:HP_0011479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010284 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001093 obo:IAO_0000115 "The presence of developmental dysplasia of the optic nerve." ; oboInOwl:hasDbXref "UMLS:C2676026" ; oboInOwl:id "HP:0001093" ; a owl:Class ; rdfs:label "Optic nerve dysplasia" ; rdfs:subClassOf obo:HP_0000587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001094 obo:IAO_0000115 "A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body." ; oboInOwl:hasDbXref "MSH:D015863", "SNOMEDCT_US:77971008", "UMLS:C0022073" ; oboInOwl:id "HP:0001094" ; a owl:Class ; rdfs:label "Iridocyclitis" ; rdfs:subClassOf obo:HP_0012122 . obo:HP_0001095 oboInOwl:hasDbXref "MSH:D058437", "SNOMEDCT_US:6962006", "UMLS:C0152132" ; oboInOwl:id "HP:0001095" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Hypertensive retinopathy" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0001096 obo:IAO_0000115 "Inflammation of the cornea and conjunctiva." ; oboInOwl:hasDbXref "MSH:D007637", "SNOMEDCT_US:88151007", "UMLS:C0022573" ; oboInOwl:id "HP:0001096" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Keratoconjunctivitis" ; rdfs:subClassOf obo:HP_0000491, obo:HP_0000509 . obo:HP_0001097 obo:IAO_0000115 "Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids." ; oboInOwl:hasDbXref "MSH:C531719", "MSH:D007638", "MSH:D014985", "MSH:D015352", "SNOMEDCT_US:302896008", "SNOMEDCT_US:363677007", "SNOMEDCT_US:46152009", "UMLS:C0013238", "UMLS:C0022575", "UMLS:C0043349", "UMLS:C2930821" ; oboInOwl:hasExactSynonym "Dry eyes", "Keratitis sicca", "Xerophthalmia" ; oboInOwl:hasRelatedSynonym "Dry eye syndrome" ; oboInOwl:id "HP:0001097" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Keratoconjunctivitis sicca" ; rdfs:subClassOf obo:HP_0001096 . obo:HP_0001098 obo:IAO_0000115 "Any structural abnormality of the fundus of the eye." ; oboInOwl:hasDbXref "UMLS:C4025804" ; oboInOwl:hasExactSynonym "Abnormality of the fundus" ; oboInOwl:id "HP:0001098" ; a owl:Class ; rdfs:label "Abnormal fundus morphology" ; rdfs:subClassOf obo:HP_0004329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003951 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001099 oboInOwl:hasDbXref "UMLS:C2673929" ; oboInOwl:id "HP:0001099" ; a owl:Class ; rdfs:label "Fundus atrophy" ; rdfs:subClassOf obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003951 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001100 obo:IAO_0000115 "Heterochromia iridis is a difference in the color of the iris in the two eyes." ; oboInOwl:hasDbXref "MSH:C538115", "SNOMEDCT_US:247033008", "UMLS:C0423318" ; oboInOwl:hasExactSynonym "Different colored eyes", "Different coloured eyes", "Heterochromia irides" ; oboInOwl:id "HP:0001100" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Heterochromia iridis" ; rdfs:subClassOf obo:HP_0200064 . obo:HP_0001101 obo:IAO_0000115 "Inflammation of the iris." ; oboInOwl:hasDbXref "MSH:D007500", "SNOMEDCT_US:65074000", "UMLS:C0022081" ; oboInOwl:hasExactSynonym "Inflammation of iris" ; oboInOwl:id "HP:0001101" ; a owl:Class ; rdfs:label "Iritis" ; rdfs:subClassOf obo:HP_0000525 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001102 obo:IAO_0000115 "Irregular lines in the deep retina that are typically configured in a radiating fashion and emanate from the optic disc. Angioid streaks are crack-like dehiscences in abnormally thickened and calcified Bruch's membrane, resulting in atrophy of the overlying retinal pigment epithelium. They may be associated with a number of endocrine, metabolic, and connective tissue abnormalities but are frequently idiopathic." ; oboInOwl:hasDbXref "MSH:D000793", "UMLS:C0002982" ; oboInOwl:hasExactSynonym "Angioid streaks", "Angioid streaks of the retina", "Angioid streaks, retina", "Knapp streaks", "Laquer cracks of the retina" ; oboInOwl:id "HP:0001102" ; a owl:Class ; rdfs:comment "Angioid streaks result from breaks in a weakened Bruch's membrane." ; rdfs:label "Angioid streaks of the fundus" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0001103 obo:IAO_0000115 "A structural abnormality of the macula lutea, which is an oval-shaped highly pigmented yellow spot near the center of the retina." ; oboInOwl:hasDbXref "SNOMEDCT_US:312999006", "UMLS:C0730362" ; oboInOwl:hasExactSynonym "Abnormality of the macula", "Macula abnormality", "Macular abnormality" ; oboInOwl:id "HP:0001103" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The term macula derives from the presence of the xanthophyll pigments, lutein and zeaxanthin, in a region five to six millimetres in diameter at the posterior pole of the eye, appearing as a yellow spot (macula lutea), when viewed in red-free light." ; rdfs:label "Abnormal macular morphology" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001104 obo:IAO_0000115 "Underdevelopment of the macula lutea." ; oboInOwl:hasDbXref "UMLS:C1849412" ; oboInOwl:id "HP:0001104" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Macular hypoplasia" ; rdfs:subClassOf obo:HP_0008059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001105 obo:IAO_0000115 "Well-demarcated area(s) of partial or complete depigmentation in the fundus, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss." ; oboInOwl:hasDbXref "MSH:D012162", "SNOMEDCT_US:405722004", "SNOMEDCT_US:95695004", "UMLS:C0035304", "UMLS:C0521694" ; oboInOwl:id "HP:0001105" ; a owl:Class ; rdfs:label "Retinal atrophy" ; rdfs:subClassOf obo:HP_0000546 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001106 obo:IAO_0000115 "Increased pigmentation of the skin in the region surrounding the orbit of the eye." ; oboInOwl:hasDbXref "UMLS:C1844606" ; oboInOwl:hasExactSynonym "Dark circles around the eyes", "Dark circles under the eyes", "Darkening around the eyes", "Idiopathic cutaneous hyperchromia at the orbital region", "Infraorbital pigmentation", "Periorbital melanosis", "Pigmentation around the eyes" ; oboInOwl:id "HP:0001106" ; a owl:Class ; rdfs:label "Periorbital hyperpigmentation" ; rdfs:subClassOf obo:HP_0000606, obo:HP_0001000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004090 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001107 obo:IAO_0000115 "An abnormal reduction in the amount of pigmentation (reduced or absent) of the iris and retina." ; oboInOwl:hasAlternativeId "HP:0007745", "HP:0007837" ; oboInOwl:hasDbXref "MSH:D016117", "SNOMEDCT_US:26399002", "UMLS:C0078917" ; oboInOwl:hasExactSynonym "Absent pigmentation in the eye", "Albinism, Ocular" ; oboInOwl:id "HP:0001107" ; a owl:Class ; rdfs:comment "Ocular pigmentation is essential for normal vision, and persons with ocular albinism tend to have severely reduced visual acuity often associated with nystagmus, strabismus, and photophobia." ; rdfs:label "Ocular albinism" ; rdfs:subClassOf obo:HP_0001098, obo:HP_0007730 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006582 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010230 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001112 obo:IAO_0000115 "Degeneration of retinal ganglion cells and their axons." ; oboInOwl:hasAlternativeId "HP:0001086" ; oboInOwl:hasDbXref "MSH:D029242", "SNOMEDCT_US:58610003", "UMLS:C0917796" ; oboInOwl:hasExactSynonym "Leber optic atrophy features", "Leber optic degeneration" ; oboInOwl:id "HP:0001112" ; a owl:Class ; rdfs:label "Leber optic atrophy" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0001113 obo:IAO_0100001 "HP:0000518" ; oboInOwl:id "HP:0001113" ; a owl:Class ; rdfs:label "obsolete Early cataracts" ; owl:deprecated true . obo:HP_0001114 obo:IAO_0000115 "The presence of xanthomata in the skin of the eyelid." ; oboInOwl:hasDbXref "MSH:D014973", "SNOMEDCT_US:63103006", "SNOMEDCT_US:6400008", "SNOMEDCT_US:75594004", "UMLS:C0155210", "UMLS:C0302314", "UMLS:C4280601", "UMLS:C4280602" ; oboInOwl:hasExactSynonym "Fatty deposits in skin around the eyes", "Fatty deposits on eyelids", "Xanthelasma palpebrarum", "Xanthoma" ; oboInOwl:hasNarrowSynonym "Xanthelasma of eyelid", "Xanthelasma of periocular region", "Xanthoma of eyelid", "Xanthoma of periocular region" ; oboInOwl:id "HP:0001114" ; a owl:Class ; rdfs:label "Xanthelasma" ; rdfs:subClassOf obo:HP_0000991, obo:HP_0010732 . obo:HP_0001115 obo:IAO_0000115 "A polar cataract that affects the posterior pole of the lens." ; oboInOwl:hasDbXref "UMLS:C1850191" ; oboInOwl:hasExactSynonym "Polar cataract, posterior" ; oboInOwl:id "HP:0001115" ; a owl:Class ; rdfs:label "Posterior polar cataract" ; rdfs:subClassOf obo:HP_0010696 . obo:HP_0001116 obo:IAO_0000115 "A congenital defect of the macula distinct from coloboma associated with optic fissure closure defects. Macular coloboma is characterized by a sharply defined, rather large defect in the central area of the fundus that is oval or round, and coarsely pigmented." ; oboInOwl:hasDbXref "MSH:C535968", "UMLS:C1852767" ; oboInOwl:hasExactSynonym "Coloboma of the macula" ; oboInOwl:id "HP:0001116" ; a owl:Class ; rdfs:label "Macular coloboma" ; rdfs:subClassOf obo:HP_0000480, obo:HP_0001103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001117 obo:IAO_0000115 "Severe loss of visual acuity within hours or days. This is characteristic of Leber hereditary optic neuropathy." ; oboInOwl:hasBroadSynonym "Sudden decrease in vision" ; oboInOwl:hasDbXref "UMLS:C4025803", "UMLS:C4072828", "UMLS:C4280600" ; oboInOwl:hasRelatedSynonym "Sudden central visual loss" ; oboInOwl:id "HP:0001117" ; a owl:Class ; rdfs:label "Sudden loss of visual acuity" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0001118 obo:IAO_0000115 "A type of cataract that is not apparent at birth but that arises in childhood or adolescence." ; oboInOwl:hasDbXref "SNOMEDCT_US:399336001", "UMLS:C0302254" ; oboInOwl:id "HP:0001118" ; a owl:Class ; rdfs:comment "Juvenile cataracts are generally either hereditary (especially if bilateral) or due to trauma (especially if unilateral)." ; rdfs:label "Juvenile cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0001119 obo:IAO_0000115 "Limbus-to-limbus corneal thinning, often greatest in the periphery, with globular protrusion of the cornea." ; oboInOwl:hasDbXref "UMLS:C3887531" ; oboInOwl:id "HP:0001119" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Keratoglobus" ; rdfs:subClassOf obo:HP_0007700, obo:HP_0100689, obo:HP_0100692 . obo:HP_0001120 obo:IAO_0000115 "Any abnormality of the size or morphology of the cornea." ; oboInOwl:hasDbXref "UMLS:C4025802" ; oboInOwl:id "HP:0001120" ; a owl:Class ; rdfs:label "Abnormality of corneal size" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001122 oboInOwl:consider "HP:0000610" ; oboInOwl:id "HP:0001122" ; a owl:Class ; rdfs:label "obsolete Aplasia/Hypoplasia of the choroid" ; owl:deprecated true . obo:HP_0001123 oboInOwl:hasDbXref "SNOMEDCT_US:12184005", "UMLS:C3887875" ; oboInOwl:hasExactSynonym "Partial loss of field of vision", "Visual field defects" ; oboInOwl:id "HP:0001123" ; a owl:Class ; rdfs:label "Visual field defect" ; rdfs:subClassOf obo:HP_0000505 . obo:HP_0001125 obo:IAO_0000115 "Transient blurring of vision associated with the aura phase of migraine." ; oboInOwl:hasAlternativeId "HP:0000583" ; oboInOwl:hasDbXref "UMLS:C1865332" ; oboInOwl:hasExactSynonym "Hemianoptic blurring of vision", "Transient unilateral blurred vision" ; oboInOwl:hasRelatedSynonym "Hemianopic blurring" ; oboInOwl:id "HP:0001125" ; a owl:Class ; rdfs:comment "The anterior segment comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens." ; rdfs:label "Transient unilateral blurring of vision" ; rdfs:subClassOf obo:HP_0000622 . obo:HP_0001126 obo:IAO_0000115 "Cryptophthalmos is a condition of total absence of eyelids and the skin of forehead is continuous with that of cheek, in which the eyeball is completely concealed by the skin, which is stretched over the orbital cavity." ; oboInOwl:hasAlternativeId "HP:0008032" ; oboInOwl:hasDbXref "SNOMEDCT_US:400951005", "UMLS:C0311249" ; oboInOwl:id "HP:0001126" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Failure of eyelid formation. Crypopthalmos is typically associated with a rudimentary or small globe. Frequently, a tuft of hair accompanies the aberrant skin." ; rdfs:label "Cryptophthalmos" ; rdfs:subClassOf obo:HP_0011226 . obo:HP_0001128 obo:IAO_0000115 "Inversion and rubbing of the eyelashes against the globe of the eye." ; oboInOwl:hasDbXref "MSH:D058457", "SNOMEDCT_US:60332004", "UMLS:C0221259" ; oboInOwl:hasExactSynonym "Ingrown eyelashes", "Introversion of eyelashes", "Trichiasis of eyelid eyelashes" ; oboInOwl:id "HP:0001128" ; a owl:Class ; rdfs:comment "Eyelash inversion." ; rdfs:label "Trichiasis" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001129 oboInOwl:hasDbXref "UMLS:C4025800" ; oboInOwl:hasExactSynonym "Large central loss of field of vision" ; oboInOwl:id "HP:0001129" ; a owl:Class ; rdfs:label "Large central visual field defect" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0001131 obo:IAO_0000115 "The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea." ; oboInOwl:hasAlternativeId "HP:0007775", "HP:0008005" ; oboInOwl:hasDbXref "SNOMEDCT_US:5587004", "UMLS:C0010036" ; oboInOwl:id "HP:0001131" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Corneal dystrophy" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001132 obo:IAO_0000115 "Partial dislocation of the lens of the eye." ; oboInOwl:hasDbXref "MSH:D007906", "SNOMEDCT_US:65814009", "UMLS:C0023316" ; oboInOwl:hasExactSynonym "Partially dislocated lens" ; oboInOwl:id "HP:0001132" ; a owl:Class ; rdfs:comment "Partial dislocation of the lens of the eye can be recognized by trembling of the iris (iridodonesis)." ; rdfs:label "Lens subluxation" ; rdfs:subClassOf obo:HP_0001083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001133 obo:IAO_0000115 "An absolute or relative decrease in retinal sensitivity extending from edge (periphery) of the visual field in a concentric pattern. The visual field is the area that is perceived simultaneously by a fixating eye." ; oboInOwl:hasAlternativeId "HP:0007887", "HP:0007981" ; oboInOwl:hasDbXref "SNOMEDCT_US:1151008", "SNOMEDCT_US:267628004", "UMLS:C0235095" ; oboInOwl:hasExactSynonym "Concentric narrowing of visual field", "Constricted visual field", "Constricted visual fields", "Limited peripheral vision", "Reduced peripheral vision", "Visual field constriction" ; oboInOwl:id "HP:0001133" ; a owl:Class ; rdfs:label "Constriction of peripheral visual field" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0001134 obo:IAO_0000115 "A polar cataract that affects the anterior pole of the lens." ; oboInOwl:hasDbXref "MSH:C538282", "UMLS:C1855179" ; oboInOwl:hasExactSynonym "Polar cataract, anterior" ; oboInOwl:id "HP:0001134" ; a owl:Class ; rdfs:label "Anterior polar cataract" ; rdfs:subClassOf obo:HP_0010696 . obo:HP_0001135 oboInOwl:hasAlternativeId "HP:0007712", "HP:0007920" ; oboInOwl:hasDbXref "UMLS:C1857627" ; oboInOwl:id "HP:0001135" ; a owl:Class ; rdfs:label "Chorioretinal dystrophy" ; rdfs:subClassOf obo:HP_0000532, obo:HP_0000556 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0001136 obo:IAO_0000115 "The presence of an increased number of twists and turns of the retinal arterioles." ; oboInOwl:hasDbXref "UMLS:C1843517" ; oboInOwl:hasExactSynonym "Tortuous retinal arterioles" ; oboInOwl:id "HP:0001136" ; a owl:Class ; rdfs:label "Retinal arteriolar tortuosity" ; rdfs:subClassOf obo:HP_0000630, obo:HP_0012841 . obo:HP_0001137 obo:IAO_0000115 "Esotropia in which either eye may be used for fixation." ; oboInOwl:hasDbXref "SNOMEDCT_US:39837002", "UMLS:C0152205" ; oboInOwl:hasExactSynonym "Alternating cross eyes" ; oboInOwl:id "HP:0001137" ; a owl:Class ; rdfs:comment "Alternating suggests that the patient may be using either eye to fixate (which means that you do not have the same one eye squinting all the time)." ; rdfs:label "Alternating esotropia" ; rdfs:subClassOf obo:HP_0000565 . obo:HP_0001138 oboInOwl:hasAlternativeId "HP:0007806" ; oboInOwl:hasDbXref "SNOMEDCT_US:82108004", "UMLS:C3887709" ; oboInOwl:hasExactSynonym "Damaged optic nerve" ; oboInOwl:id "HP:0001138" ; a owl:Class ; rdfs:label "Optic neuropathy" ; rdfs:subClassOf obo:HP_0000587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001139 oboInOwl:hasDbXref "MSH:D015794", "SNOMEDCT_US:75241009", "UMLS:C0008525" ; oboInOwl:id "HP:0001139" ; a owl:Class ; rdfs:label "Choroideremia" ; rdfs:subClassOf obo:HP_0000610 . obo:HP_0001140 obo:IAO_0000115 "A benign tumor typically found at the junction of the cornea and sclera (limbal epibullar dermoid)." ; oboInOwl:hasBroadSynonym "Benign eye tumor", "Benign eye tumour" ; oboInOwl:hasDbXref "SNOMEDCT_US:5131000119107", "SNOMEDCT_US:92097004", "UMLS:C0496897", "UMLS:C1867616" ; oboInOwl:hasExactSynonym "Epibulbar dermoid", "Epibulbar dermoids" ; oboInOwl:id "HP:0001140" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limbal dermoid" ; rdfs:subClassOf obo:HP_0000481, obo:HP_0000502, obo:HP_0000591 . obo:HP_0001141 obo:IAO_0000115 "Severe reduction of the ability to see defined as visual acuity less than 6/60 (20/200 in US notation; 0.1 in decimal notation) but at least 3/60 (20/400 in US notation; 0.05 in decimal notation)." ; oboInOwl:hasAlternativeId "HP:0007640", "HP:0007842", "HP:0007951", "HP:0008023" ; oboInOwl:hasDbXref "SNOMEDCT_US:397541004", "UMLS:C1301509" ; oboInOwl:hasExactSynonym "Marked vision impairment", "Severe reduction in visual acuity", "Severe vision loss", "Severe visual impairment", "Severe visual loss", "Severely impaired vision" ; oboInOwl:id "HP:0001141" ; a owl:Class ; rdfs:label "Severely reduced visual acuity" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0001142 obo:IAO_0000115 "A conical projection of the anterior or posterior surface of the lens, occurring as a developmental anomaly." ; oboInOwl:hasDbXref "SNOMEDCT_US:253221000", "UMLS:C0239119" ; oboInOwl:id "HP:0001142" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A conical projection of the anterior or posterior surface of the lens." ; rdfs:label "Lenticonus" ; rdfs:subClassOf obo:HP_0011526 . obo:HP_0001144 obo:IAO_0000115 "Presence of a cyst in the region of the periorbital tissues. Orbital cysts can be derived from epithelial or glandular tissue within or surrounding the orbit (lacrimal glands, salivary glands, conjunctival, oral, nasal, or sinus epithelium)." ; oboInOwl:hasDbXref "SNOMEDCT_US:31021007", "UMLS:C0155285" ; oboInOwl:hasExactSynonym "Cyst of eye socket", "Orbital cysts" ; oboInOwl:id "HP:0001144" ; a owl:Class ; rdfs:label "Orbital cyst" ; rdfs:subClassOf obo:HP_0000315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001145 oboInOwl:consider "HP:0000532" ; oboInOwl:id "HP:0001145" ; a owl:Class ; rdfs:label "obsolete Chorioretinopathy" ; owl:deprecated true . obo:HP_0001146 obo:IAO_0100001 "HP:0000580" ; oboInOwl:id "HP:0001146" ; a owl:Class ; rdfs:label "obsolete Pigmentary retinal degeneration" ; owl:deprecated true . obo:HP_0001147 obo:IAO_0000115 "Fluid which has escaped from retinal blood vessels with a high concentration of lipid, protein, and cellular debris with a typically bright, reflective, white or cream colored appearance on the surface of the retina." ; oboInOwl:hasDbXref "SNOMEDCT_US:39832008", "UMLS:C0240897" ; oboInOwl:hasExactSynonym "Retinal exudates" ; oboInOwl:id "HP:0001147" ; a owl:Class ; rdfs:comment "Retinal exudates indicate increased vessel permeability and an associated risk of retinal edema." ; rdfs:label "Retinal exudate" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0001149 obo:IAO_0000115 "The presence of fine, branching linear opacities in Bowman's layer in the central area that may spread to the periphery in the clinical course. The deep corneal stroma may be involved but the process does not reach Descemet's membrane. Recurrent corneal erosion may occur. Histologic examination reveals amyloid deposits in the collagen fibers of the cornea." ; oboInOwl:hasDbXref "MSH:D028227", "SNOMEDCT_US:1192004", "SNOMEDCT_US:361199007", "UMLS:C0155127" ; oboInOwl:hasExactSynonym "Biber haab dimmer dystrophy" ; oboInOwl:id "HP:0001149" ; a owl:Class ; rdfs:label "Lattice corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0001150 oboInOwl:consider "HP:0000532" ; oboInOwl:id "HP:0001150" ; a owl:Class ; rdfs:label "obsolete Choroidal sclerosis" ; owl:deprecated true . obo:HP_0001151 obo:IAO_0000115 "An abnormality of ocular smooth pursuit characterized by an impairment of the ability to track horizontally moving objects." ; oboInOwl:hasDbXref "UMLS:C1866753" ; oboInOwl:hasExactSynonym "Abnormal horizontal ocular pursuit", "Impaired horizontal visual pursuit" ; oboInOwl:id "HP:0001151" ; a owl:Class ; rdfs:label "Impaired horizontal smooth pursuit" ; rdfs:subClassOf obo:HP_0007772 . obo:HP_0001152 obo:IAO_0000115 "An abnormality of tracking eye movements in which smooth pursuit is interrupted by an abnormally high number of saccadic movements." ; oboInOwl:hasAlternativeId "HP:0000530" ; oboInOwl:hasDbXref "UMLS:C1836479" ; oboInOwl:hasExactSynonym "Saccadic pursuit movements", "Saccadic slow pursuit" ; oboInOwl:id "HP:0001152" ; a owl:Class ; rdfs:comment "Tracking eye movements consist of two different components, namely, smooth pursuit and saccades. Smooth pursuit, or just pursuit, is a class of rather slow eye movements that minimizes retinal target motion. Saccades are rapid eye movements that align the fovea with the target." ; rdfs:label "Saccadic smooth pursuit" ; rdfs:subClassOf obo:HP_0000617 . obo:HP_0001153 obo:IAO_0000115 "The presence of a vaginal septum, thereby creating a vaginal duplication. The septum is longitudinal in the majority of cases." ; oboInOwl:hasDbXref "SNOMEDCT_US:47054003", "UMLS:C0266411" ; oboInOwl:hasExactSynonym "Double vagina" ; oboInOwl:id "HP:0001153" ; a owl:Class ; rdfs:label "Septate vagina" ; rdfs:subClassOf obo:HP_0000142 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001155 obo:IAO_0000115 "An abnormality affecting one or both hands." ; oboInOwl:hasAlternativeId "HP:0005858" ; oboInOwl:hasDbXref "MSH:D006226", "SNOMEDCT_US:299033004", "UMLS:C0018564" ; oboInOwl:hasExactSynonym "Abnormal hands", "Abnormality of the hand", "Hand anomalies", "Hand deformities" ; oboInOwl:id "HP:0001155" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the hand" ; rdfs:subClassOf obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001156 obo:IAO_0000115 "Digits that appear disproportionately short compared to the hand/foot. The word brachydactyly is used here to describe a series distinct patterns of shortened digits (brachydactyly types A-E). This is the sense used here." ; oboInOwl:hasAlternativeId "HP:0001189", "HP:0001201", "HP:0005630", "HP:0005657", "HP:0005727", "HP:0006017", "HP:0006128", "HP:0100667" ; oboInOwl:hasDbXref "MSH:D059327", "SNOMEDCT_US:43476002", "UMLS:C0221357" ; oboInOwl:hasExactSynonym "Brachydactyly syndrome", "Short fingers or toes" ; oboInOwl:id "HP:0001156" ; a owl:Class ; rdfs:label "Brachydactyly" ; rdfs:subClassOf obo:HP_0011927 . obo:HP_0001159 obo:IAO_0000115 "Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are referred to as \"symphalangism\"." ; oboInOwl:hasAlternativeId "HP:0001206", "HP:0001236" ; oboInOwl:hasDbXref "Fyler:4174", "MSH:D013576", "SNOMEDCT_US:373413006", "UMLS:C0039075" ; oboInOwl:hasExactSynonym "Webbed fingers or toes" ; oboInOwl:id "HP:0001159" ; a owl:Class ; rdfs:comment "Syndactyly may be partial or complete. In complete syndactyly, the skin is joined all the way to the fingertip. In partial (incomplete) syndactyly, the skin is only joined part of the distance to the fingertip." ; rdfs:label "Syndactyly" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0001770 obo:HP_0006101 ) ] ] . obo:HP_0001161 obo:IAO_0000115 "A kind of polydactyly characterized by the presence of a supernumerary finger or fingers." ; oboInOwl:hasDbXref "MEDDRA:10036064", "SNOMEDCT_US:81793007", "UMLS:C0158733" ; oboInOwl:hasExactSynonym "Extra finger", "Finger polydactyly", "Polydactyly of the hand", "Supernumerary finger" ; oboInOwl:id "HP:0001161" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hand polydactyly" ; rdfs:subClassOf obo:HP_0009997, obo:HP_0010442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002389 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001162 obo:IAO_0000115 "Supernumerary digits located at the ulnar side of the hand (that is, on the side with the fifth finger)." ; oboInOwl:hasAlternativeId "HP:0004698", "HP:0005763", "HP:0009984" ; oboInOwl:hasDbXref "SNOMEDCT_US:205131007", "UMLS:C0431904" ; oboInOwl:hasExactSynonym "Extra little finger", "Extra pinkie finger", "Extra pinky finger", "Polydactyly affecting the 5th finger", "Postaxial polydactyly of fingers", "Postaxial polydactyly of hand", "Postaxial polydactyly of hands" ; oboInOwl:id "HP:0001162" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Postaxial hand polydactyly" ; rdfs:subClassOf obo:HP_0001161, obo:HP_0004207, obo:HP_0100259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003625 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001163 obo:IAO_0100001 "HP:0005916" ; oboInOwl:id "HP:0001163" ; a owl:Class ; rdfs:label "Abnormality of the metacarpal bones" ; owl:deprecated true . obo:HP_0001166 obo:IAO_0000115 "Abnormally long and slender fingers (\"spider fingers\")." ; oboInOwl:hasAlternativeId "HP:0001505" ; oboInOwl:hasDbXref "MSH:D054119", "SNOMEDCT_US:62250003", "UMLS:C0003706" ; oboInOwl:hasExactSynonym "Long slender fingers", "Long, slender fingers", "Spider fingers" ; oboInOwl:id "HP:0001166" ; a owl:Class ; rdfs:label "Arachnodactyly" ; rdfs:subClassOf obo:HP_0001238, obo:HP_0100807 . obo:HP_0001167 obo:IAO_0000115 "An anomaly of a finger." ; oboInOwl:hasAlternativeId "HP:0003035" ; oboInOwl:hasDbXref "UMLS:C2674737" ; oboInOwl:hasExactSynonym "Abnormalities of the fingers", "Abnormality of finger" ; oboInOwl:id "HP:0001167" ; a owl:Class ; rdfs:label "Abnormal finger morphology" ; rdfs:subClassOf obo:HP_0001155, obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002389 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001169 obo:IAO_0000115 "For children from birth to 4 years of age the palm width is more than 2 SD above the mean; for children from 4 to 16 years of age the palm width is above the 95th centile; or, the width of the palm appears disproportionately wide for the length." ; oboInOwl:hasAlternativeId "HP:0001174" ; oboInOwl:hasDbXref "SNOMEDCT_US:48251003", "UMLS:C0264142" ; oboInOwl:hasExactSynonym "Broad hand", "Broad hands", "Broad palm", "Wide palm" ; oboInOwl:id "HP:0001169" ; a owl:Class ; rdfs:comment "Hand width is measured across the palm at the level of the MCPJ (radial aspect of the second MCPJ to the ulnar aspect of the fifth MCPJ) [Hall et al., 2007]. Caution is advised with the subjective assessment as short metacarpals can mimic a broad palm. In persons with polydactyly that includes a supernumerary metacarpal, that should be separately coded and the measurement technique from Hall et al, [2007] would need to be modified to account for the supernumerary digit (i.e., with postaxial polydactyly, measure to the sixth MCPJ)." ; rdfs:label "Broad palm" ; rdfs:subClassOf obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001171 obo:IAO_0000115 "A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middel fingers as far as oligo- or monodactyl hands." ; oboInOwl:hasAlternativeId "HP:0001247", "HP:0003050" ; oboInOwl:hasDbXref "SNOMEDCT_US:299034005", "UMLS:C0221373" ; oboInOwl:hasExactSynonym "Ectrodactyly of the hand", "Hand ectrodactyly", "Split hand", "Split-hand" ; oboInOwl:id "HP:0001171" ; a owl:Class ; rdfs:label "Split hand" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0100257 . obo:HP_0001172 obo:IAO_0000115 "An abnormal structure of the first digit of the hand." ; oboInOwl:hasDbXref "MSH:C536903", "SNOMEDCT_US:299130003", "UMLS:C0575897" ; oboInOwl:hasExactSynonym "Abnormality of the thumb", "Abnormality of the thumbs", "Thumb deformity" ; oboInOwl:id "HP:0001172" ; a owl:Class ; rdfs:label "Abnormal thumb morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001176 oboInOwl:hasAlternativeId "HP:0002820", "HP:0006044", "HP:0006219" ; oboInOwl:hasDbXref "SNOMEDCT_US:249752003", "UMLS:C0426870" ; oboInOwl:hasExactSynonym "Disproportionately large hands", "Large hands", "large hand" ; oboInOwl:id "HP:0001176" ; a owl:Class ; rdfs:label "Large hands" ; rdfs:subClassOf obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001177 obo:IAO_0000115 "Supernumerary digits located at the radial side of the hand. Polydactyly (supernumerary digits) involving the thumb occurs in many distinct forms of high variability and severity. Ranging from fleshy nubbins over varying degrees of partial duplication/splitting to completely duplicated or even triplicated thumbs or preaxial (on the radial side of the hand) supernumerary digits." ; oboInOwl:hasAlternativeId "HP:0005629", "HP:0005634", "HP:0006182", "HP:0009604" ; oboInOwl:hasDbXref "MSH:C536332", "SNOMEDCT_US:205135003", "SNOMEDCT_US:445216006", "UMLS:C1395852" ; oboInOwl:hasExactSynonym "Extra thumb", "Polydactyly affecting the thumb", "Preaxial polydactyly of hands", "Supernumerary thumb", "thumb polydactyly" ; oboInOwl:id "HP:0001177" ; a owl:Class ; rdfs:label "Preaxial hand polydactyly" ; rdfs:subClassOf obo:HP_0001161, obo:HP_0001172, obo:HP_0100258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001178 obo:IAO_0000115 "An abnormal hand position characterized by hyperextension of the fourth and fifth fingers at the metacarpophalangeal joints and flexion of the interphalangeal joints of the same fingers such that they are curled towards the palm." ; oboInOwl:hasDbXref "UMLS:C4025799" ; oboInOwl:id "HP:0001178" ; a owl:Class ; rdfs:comment "An ulnar claw, also known as claw hand, is an abnormal hand position that is associated with lesions of the ulnar nerve. Note that ulnar claw is to be distinguished from ectrodactyly, which also can be referred to as claw hand." ; rdfs:label "Ulnar claw" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0001180 obo:IAO_0000115 "A developmental defect resulting in the presence of fewer than the normal number of fingers." ; oboInOwl:hasDbXref "SNOMEDCT_US:71358006", "UMLS:C0728895" ; oboInOwl:hasExactSynonym "Hand has less than 5 fingers" ; oboInOwl:id "HP:0001180" ; a owl:Class ; rdfs:label "Hand oligodactyly" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0012165 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002389 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001181 obo:IAO_0000115 "In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger." ; oboInOwl:hasAlternativeId "HP:0005646" ; oboInOwl:hasDbXref "UMLS:C3554617" ; oboInOwl:hasExactSynonym "Adducted thumbs", "Inward turned thumb", "Thumb-in-palm deformity", "Thumb-in-palm pattern" ; oboInOwl:id "HP:0001181" ; a owl:Class ; rdfs:comment "The thumb is both flexed and adducted. Lesser degrees of adduction than that specified here may warrant the use of this term, for example, when the tip of the thumb lies near the base of F2 or F3." ; rdfs:label "Adducted thumb" ; rdfs:subClassOf obo:HP_0001172 . obo:HP_0001182 obo:IAO_0000115 "The gradual reduction in girth of the finger from proximal to distal." ; oboInOwl:hasAlternativeId "HP:0005795", "HP:0005800", "HP:0006032", "HP:0006080", "HP:0006098", "HP:0006111", "HP:0006125", "HP:0006244", "HP:0007532" ; oboInOwl:hasDbXref "SNOMEDCT_US:249768009", "UMLS:C0426886" ; oboInOwl:hasExactSynonym "Distally tapering fingers", "Tapered finger", "Tapered fingertips", "Tapering fingers" ; oboInOwl:hasRelatedSynonym "Tapered fingers" ; oboInOwl:id "HP:0001182" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Tapered finger" ; rdfs:subClassOf obo:HP_0100807 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001187 obo:IAO_0000115 "The ability of the finger joints to move beyond their normal range of motion." ; oboInOwl:hasAlternativeId "HP:0006158" ; oboInOwl:hasDbXref "UMLS:C1844577" ; oboInOwl:hasExactSynonym "Finger joint hyperextensibility", "Hyperextensible digits", "Hyperextensible finger" ; oboInOwl:hasRelatedSynonym "Hyperextensible fingers" ; oboInOwl:id "HP:0001187" ; a owl:Class ; rdfs:label "Hyperextensibility of the finger joints" ; rdfs:subClassOf obo:HP_0006094 . obo:HP_0001188 obo:IAO_0000115 "An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted." ; oboInOwl:hasDbXref "UMLS:C0239815" ; oboInOwl:hasExactSynonym "Clenched hand", "Clenched hands", "Hand clenching" ; oboInOwl:id "HP:0001188" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hand clenching is commonly characterized by malpositioning of the fingers characterized by radial deviation of the 4th and 5th digits and ulnar deviation of the 2nd digit over the 3rd finger. Hand clenching is distinguished from Camptodactyly, as that term may describe fewer than five digits of a eudactylous hand and does not involve the MCPJ. The digits may overlap when they lie flexed in the palm. It is not necessary to specify the overlapping fingers finding separately." ; rdfs:label "Hand clenching" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0001191 obo:IAO_0000115 "An abnormality affecting the carpal bones of the wrist (scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate, hamate)." ; oboInOwl:hasBroadSynonym "Abnormal wrist bones" ; oboInOwl:hasDbXref "UMLS:C1840535" ; oboInOwl:hasExactSynonym "Abnormal carpal bones", "Abnormality of the carpal bones", "Anomalous carpal bones", "Carpal bone anomalies" ; oboInOwl:id "HP:0001191" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal carpal morphology" ; rdfs:subClassOf obo:HP_0003019, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001193 oboInOwl:hasDbXref "UMLS:C4048199" ; oboInOwl:id "HP:0001193" ; a owl:Class ; rdfs:label "Ulnar deviation of the hand or of fingers of the hand" ; rdfs:subClassOf obo:HP_0009484 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009465 obo:HP_0009487 ) ] ] . obo:HP_0001194 obo:IAO_0000115 "An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta)." ; oboInOwl:hasDbXref "UMLS:C4025798" ; oboInOwl:hasExactSynonym "Abnormalities of placenta or umbilical cord" ; oboInOwl:id "HP:0001194" ; a owl:Class ; rdfs:label "Abnormalities of placenta or umbilical cord" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0001195 obo:IAO_0000115 "Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord." ; oboInOwl:hasDbXref "MSH:D058529", "SNOMEDCT_US:204470001", "UMLS:C1384670" ; oboInOwl:hasExactSynonym "2 vessel cord", "2 vessel umbilical cord", "Only one artery in umbilical cord instead of two", "Two vessel cord", "Two vessel umbilical cord", "Two-vessel cord" ; oboInOwl:id "HP:0001195" ; a owl:Class ; rdfs:comment "The umbilical cord normally has two arteries and one vein." ; rdfs:label "Single umbilical artery" ; rdfs:subClassOf obo:HP_0010948, obo:HP_0011403, obo:HP_0011425 . obo:HP_0001196 obo:IAO_0000115 "Decreased length of the umbilical cord." ; oboInOwl:hasDbXref "SNOMEDCT_US:59795007", "UMLS:C0266786" ; oboInOwl:hasExactSynonym "Short umbilical cord" ; oboInOwl:id "HP:0001196" ; a owl:Class ; rdfs:label "Short umbilical cord" ; rdfs:subClassOf obo:HP_0010881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001197 obo:IAO_0000115 "An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities." ; oboInOwl:hasDbXref "UMLS:C4025797" ; oboInOwl:hasExactSynonym "Abnormality of prenatal development or birth" ; oboInOwl:id "HP:0001197" ; a owl:Class ; rdfs:comment "Because of the close link between prenatal developmental abnormalities and abnormalities of the birth process, a single term is chosen to subsume both classes of abnormality." ; rdfs:label "Abnormality of prenatal development or birth" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001199 obo:IAO_0000115 "A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb." ; oboInOwl:hasAlternativeId "HP:0005846", "HP:0006194", "HP:0009610", "HP:0009619" ; oboInOwl:hasDbXref "MSH:C573898", "SNOMEDCT_US:205308004", "UMLS:C0241397" ; oboInOwl:hasExactSynonym "Accessory phalanx of the thumb", "Digitalized thumb", "Finger-like thumb", "Triphalangeal thumbs", "Triphalangy of thumb" ; oboInOwl:id "HP:0001199" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The requirement for a single PD axis relates to the issue that partial forms of Preaxial polydactyly may comprise a partially duplicated thumb with two distal phalanges and a single proximal phalanx. That finding is instead coded as a mild form of thumb polydactyly. Note that this finding can be readily assessed by examination and/or physical manipulation of the thumb." ; rdfs:label "Triphalangeal thumb" ; rdfs:subClassOf obo:HP_0009602 . obo:HP_0001204 obo:IAO_0000115 "The term distal symphalangism refers to a bony fusion of the distal and middle phalanges of the digits of the hand, in other words the distal interphalangeal joint (DIJ) is missing which can be seen either on x-rays or as an absence of the distal interphalangeal finger creases." ; oboInOwl:hasAlternativeId "HP:0006079", "HP:0006116", "HP:0009841", "HP:0009871" ; oboInOwl:hasDbXref "UMLS:C1862158" ; oboInOwl:hasExactSynonym "Fused outermost bones of hand", "Symphalangism affecting the distal phalanges of the hand", "Synostosis of distal phalanges", "Terminal symphalangism" ; oboInOwl:id "HP:0001204" ; a owl:Class ; rdfs:label "Distal symphalangism of hands" ; rdfs:subClassOf obo:HP_0009700, obo:HP_0009773, obo:HP_0009832, obo:HP_0100263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001211 obo:IAO_0000115 "An abnormal structure of the tip (end) of a finger." ; oboInOwl:hasDbXref "UMLS:C4025796" ; oboInOwl:hasExactSynonym "Abnormality of the fingertips" ; oboInOwl:id "HP:0001211" ; a owl:Class ; rdfs:label "Abnormal fingertip morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001212 obo:IAO_0000115 "A soft tissue prominence of the ventral aspects of the fingertips. The term \"persistent fetal fingertip pads\" is often used as a synonym, but should better not be used because it implies knowledge of history of the patient which often does not exist." ; oboInOwl:hasAlternativeId "HP:0001235" ; oboInOwl:hasDbXref "UMLS:C1835807" ; oboInOwl:hasExactSynonym "Persistence of fingerpads", "Persistent fetal fingertip pads", "Persistent foetal fingertip pads", "Prominent finger pads", "Prominent fingertip pads" ; oboInOwl:id "HP:0001212" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent fingertip pads" ; rdfs:subClassOf obo:HP_0001211, obo:HP_0011298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001215 obo:IAO_0000115 "The distal interphalangeal joint and/or the proximal interphalangeal joint of the second to fifth fingers cannot be extended to 180 degrees by either active or passive extension." ; oboInOwl:hasDbXref "UMLS:C1859368" ; oboInOwl:id "HP:0001215" ; a owl:Class ; rdfs:label "Camptodactyly of 2nd-5th fingers" ; rdfs:subClassOf obo:HP_0100490 . obo:HP_0001216 obo:IAO_0000115 "Ossification of carpal bones occurs later than age-adjusted norms." ; oboInOwl:hasAlternativeId "HP:0006069" ; oboInOwl:hasDbXref "UMLS:C1841684", "UMLS:C4280599" ; oboInOwl:hasExactSynonym "Carpal delayed ossification", "Delayed carpal bone age", "Delayed carpal ossification", "Delayed maturation of carpal bones" ; oboInOwl:hasRelatedSynonym "Delayed maturation of wrist bone" ; oboInOwl:id "HP:0001216" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Delayed ossification of carpal bones" ; rdfs:subClassOf obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001217 obo:IAO_0000115 "Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails." ; oboInOwl:hasAlternativeId "HP:0003036", "HP:0005874" ; oboInOwl:hasDbXref "SNOMEDCT_US:367004", "UMLS:C0149651" ; oboInOwl:hasExactSynonym "Clubbing of fingers and toes", "Digital clubbing" ; oboInOwl:id "HP:0001217" ; a owl:Class ; rdfs:comment "Non-edematous swelling/broadening of the soft tissue of the fingertips in all dimensions (distal phalanges of the fingers)." ; rdfs:label "Clubbing" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001883 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001218 obo:IAO_0000115 "Auto-amputation is the spontaneous detachment of an appendage from the body due to long standing pathology." ; oboInOwl:hasDbXref "UMLS:C1833222" ; oboInOwl:id "HP:0001218" ; a owl:Class ; rdfs:label "Autoamputation" ; rdfs:subClassOf obo:HP_0040064 . obo:HP_0001220 obo:IAO_0000115 "Chronic loss of joint motion in an interphalangeal joint of a finger due to structural changes in non-bony tissue." ; oboInOwl:hasDbXref "UMLS:C4021784" ; oboInOwl:hasExactSynonym "Interphalangeal joint flexion contractures" ; oboInOwl:id "HP:0001220" ; a owl:Class ; rdfs:label "Interphalangeal joint contracture of finger" ; rdfs:subClassOf obo:HP_0012785 . obo:HP_0001222 obo:IAO_0000115 "Spoon-shaped, broad thumbs." ; oboInOwl:hasDbXref "UMLS:C0241395" ; oboInOwl:hasExactSynonym "Spoon shaped thumbs" ; oboInOwl:id "HP:0001222" ; a owl:Class ; rdfs:label "Spatulate thumbs" ; rdfs:subClassOf obo:HP_0011304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001937 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001223 obo:IAO_0000115 "All of the metacarpal bones of the hand have a pointed proximal appearance." ; oboInOwl:hasDbXref "UMLS:C1854787" ; oboInOwl:id "HP:0001223" ; a owl:Class ; rdfs:label "Pointed proximal second through fifth metacarpals" ; rdfs:subClassOf obo:HP_0006119 . obo:HP_0001225 oboInOwl:hasDbXref "UMLS:C0241760" ; oboInOwl:hasExactSynonym "Wrist swelling" ; oboInOwl:id "HP:0001225" ; a owl:Class ; rdfs:label "Wrist swelling" ; rdfs:subClassOf obo:HP_0003019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001851 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001226 obo:IAO_0100001 "HP:0006121" ; oboInOwl:id "HP:0001226" ; a owl:Class ; rdfs:label "obsolete Acral ulceration and osteomyelitis leading to autoamputation of digits" ; owl:deprecated true . obo:HP_0001227 obo:IAO_0000115 "An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb." ; oboInOwl:hasDbXref "UMLS:C4021783" ; oboInOwl:hasExactSynonym "Thenar abnormality" ; oboInOwl:id "HP:0001227" ; a owl:Class ; rdfs:label "Abnormality of the thenar eminence" ; rdfs:subClassOf obo:HP_0001421 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0017716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001230 obo:IAO_0000115 "Abnormally broad metacarpal bones." ; oboInOwl:hasAlternativeId "HP:0006024", "HP:0006065" ; oboInOwl:hasDbXref "UMLS:C1842229" ; oboInOwl:hasExactSynonym "Wide long bones of hand", "Wide metacarpals" ; oboInOwl:id "HP:0001230" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001231 obo:IAO_0000115 "An abnormality of the fingernails." ; oboInOwl:hasDbXref "UMLS:C4021782" ; oboInOwl:hasExactSynonym "Abnormal fingernails", "Abnormality of the fingernails" ; oboInOwl:id "HP:0001231" ; a owl:Class ; rdfs:label "Abnormal fingernail morphology" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001232 obo:IAO_0000115 "Telangiectases in the area of the nails." ; oboInOwl:hasDbXref "UMLS:C1838167" ; oboInOwl:hasExactSynonym "Nail bed telangiectases" ; oboInOwl:id "HP:0001232" ; a owl:Class ; rdfs:label "Nail bed telangiectasia" ; rdfs:subClassOf obo:HP_0001009, obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005273 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001233 obo:IAO_0000115 "Syndactyly with fusion of fingers two and three." ; oboInOwl:hasAlternativeId "HP:0006039", "HP:0006122" ; oboInOwl:hasDbXref "SNOMEDCT_US:205139009", "UMLS:C0432055" ; oboInOwl:hasExactSynonym "Syndactyly 2nd-3rd fingers", "Syndactyly, 2-3 finger", "Webbed 2nd-3rd fingers" ; oboInOwl:id "HP:0001233" ; a owl:Class ; rdfs:label "2-3 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001234 obo:IAO_0000115 "With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand." ; oboInOwl:hasAlternativeId "HP:0040021" ; oboInOwl:hasDbXref "UMLS:C1857269" ; oboInOwl:hasExactSynonym "Abducted thumb", "Hitchhiker thumb" ; oboInOwl:id "HP:0001234" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The condition known as \"hitchhiker's thumb\" means, that the distal phalanx of the thumb, when the thumb is extended (as in a \"thumbs-up\"), can extend backwards toward the nail and outwards at an angle of up to, or more than, 90 degrees from the thumb, whereas normally it will extend straight out with little backward bending." ; rdfs:label "Hitchhiker thumb" ; rdfs:subClassOf obo:HP_0009466, obo:HP_0009603, obo:HP_0009617 . obo:HP_0001238 obo:IAO_0000115 "Fingers that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual." ; oboInOwl:hasDbXref "UMLS:C1857482" ; oboInOwl:hasExactSynonym "Narrow fingers", "Slender finger", "Slender fingers", "thin fingers" ; oboInOwl:id "HP:0001238" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Slender finger" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001239 obo:IAO_0000115 "A chronic loss of wrist joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevent normal movement of the joints of the wrist." ; oboInOwl:hasAlternativeId "HP:0006049", "HP:0006137" ; oboInOwl:hasDbXref "SNOMEDCT_US:202275008", "UMLS:C0409345" ; oboInOwl:hasExactSynonym "Wrist contracture", "Wrist flexion deformity" ; oboInOwl:id "HP:0001239" ; a owl:Class ; rdfs:label "Wrist flexion contracture" ; rdfs:subClassOf obo:HP_0003019, obo:HP_0100360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001241 oboInOwl:hasDbXref "UMLS:C1857002" ; oboInOwl:hasExactSynonym "Capitate-hamate fusions", "Fused capitate and hamate", "Fusion of capitate and hamate", "Fusion of hamate and capitate" ; oboInOwl:id "HP:0001241" ; a owl:Class ; rdfs:label "Capitate-hamate fusion" ; rdfs:subClassOf obo:HP_0004259, obo:HP_0004262, obo:HP_0009702 . obo:HP_0001245 obo:IAO_0000115 "Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb." ; oboInOwl:hasAlternativeId "HP:0006188" ; oboInOwl:hasDbXref "UMLS:C1846474" ; oboInOwl:hasExactSynonym "Decreased thenar eminence", "Hypoplastic thenar eminences", "Thenar hypoplasia", "Thenar muscle hypoplasia" ; oboInOwl:id "HP:0001245" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The reduced soft tissue is typically abductor pollicis brevis and flexor pollicis brevis muscle bulk. Detection of this abnormality entails clinical judgment, especially in mild cases. The bulk of the muscle mass around the base of the thumb is diminished, and there may be a mild concavity over the volar aspect of the first metacarpal. When the deficiency is unilateral, comparison between the two hands will point up the often-subtle change in contour of the thenar muscles. If the degree of involvement is severe, the palm may taper in width proximally." ; rdfs:label "Small thenar eminence" ; rdfs:subClassOf obo:HP_0001227 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001248 obo:IAO_0000115 "Decreased length of the tubular bones of the hand, that is, the phalanges and metacarpals." ; oboInOwl:hasDbXref "UMLS:C4025795" ; oboInOwl:hasExactSynonym "Shortened short tubular bones of the hand" ; oboInOwl:id "HP:0001248" ; a owl:Class ; rdfs:label "Short tubular bones of the hand" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0005922 . obo:HP_0001249 obo:IAO_0000115 "Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70." ; oboInOwl:hasAlternativeId "HP:0000730", "HP:0001267", "HP:0001286", "HP:0002122", "HP:0002192", "HP:0002316", "HP:0002382", "HP:0002386", "HP:0002402", "HP:0002458", "HP:0002482", "HP:0002499", "HP:0002543", "HP:0003767", "HP:0006833", "HP:0006877", "HP:0007154", "HP:0007176", "HP:0007180" ; oboInOwl:hasDbXref "MSH:D008607", "SNOMEDCT_US:228156007", "SNOMEDCT_US:247578003", "SNOMEDCT_US:91138005", "UMLS:C0025362", "UMLS:C0423903", "UMLS:C0917816", "UMLS:C1843367", "UMLS:C3714756", "UMLS:C4020876" ; oboInOwl:hasExactSynonym "Intellectual disability", "Mental deficiency", "Mental retardation", "Mental retardation, nonspecific", "Mental-retardation", "Nonprogressive intellectual disability", "Nonprogressive mental retardation" ; oboInOwl:hasRelatedSynonym "Dull intelligence", "Low intelligence", "Poor school performance" ; oboInOwl:id "HP:0001249" ; a owl:Class ; rdfs:comment "This term should be used for children at least five years old. For younger children, consider the term Global developmental delay (HP:0001263)." ; rdfs:label "Intellectual disability" ; rdfs:subClassOf obo:HP_0011446, obo:HP_0012759 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001507 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001250 obo:IAO_0000115 "A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain." ; oboInOwl:hasAlternativeId "HP:0001275", "HP:0001303", "HP:0002125", "HP:0002182", "HP:0002279", "HP:0002306", "HP:0002348", "HP:0002391", "HP:0002417", "HP:0002430", "HP:0002431", "HP:0002432", "HP:0002434", "HP:0002437", "HP:0002466", "HP:0002479", "HP:0002794", "HP:0006997", "HP:0010520" ; oboInOwl:hasDbXref "MSH:D004827", "MSH:D012640", "SNOMEDCT_US:128613002", "SNOMEDCT_US:246545002", "SNOMEDCT_US:313307000", "SNOMEDCT_US:84757009", "SNOMEDCT_US:91175000", "UMLS:C0014544", "UMLS:C0036572" ; oboInOwl:hasExactSynonym "Epileptic seizure", "Seizures" ; oboInOwl:hasRelatedSynonym "Epilepsy" ; oboInOwl:id "HP:0001250" ; a owl:Class ; rdfs:comment "A type of electrographic seizure has been proposed in neonates which does not have a clinical correlate, it is electrographic only. The term epilepsy is not used to describe recurrent febrile seizures. Epilepsy presumably reflects an abnormally reduced seizure threshold." ; rdfs:label "Seizure" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001251 obo:IAO_0000115 "Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly)." ; oboInOwl:hasAlternativeId "HP:0001253", "HP:0002513", "HP:0007050", "HP:0007157" ; oboInOwl:hasDbXref "MSH:D002524", "SNOMEDCT_US:85102008", "UMLS:C0007758" ; oboInOwl:hasExactSynonym "Cerebellar ataxia" ; oboInOwl:id "HP:0001251" ; a owl:Class ; rdfs:comment "Ataxia can be differentiated into dyssynergy, asynergy, dysmetria (hypometria, hypermetria), dysdiadochokinesis, gait ataxia, truncal ataxia, limb ataxia, and dysarthria). Note: This term does not include sensory ataxia." ; rdfs:label "Ataxia" ; rdfs:subClassOf obo:HP_0011443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001252 obo:IAO_0000115 "Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist." ; oboInOwl:hasAlternativeId "HP:0011398" ; oboInOwl:hasDbXref "MSH:D009123", "SNOMEDCT_US:398151007", "SNOMEDCT_US:398152000", "UMLS:C0026827" ; oboInOwl:hasExactSynonym "Low muscle tone", "Low or weak muscle tone", "Muscle hypotonia", "Muscular hypotonia" ; oboInOwl:hasNarrowSynonym "Central hypotonia", "Peripheral hypotonia" ; oboInOwl:id "HP:0001252" ; a owl:Class ; rdfs:comment "Hypotonia can be caused by abnormalities of the central nervous system, any element of the motor unit (including the lower motoneuron), or both. Hypotonia is not a specific diagnosis, but can be observed in hundreds of genetic and other diseases. The first distinction to make when assessing a child with hypotonia is whether decreased muscle tone is a result of an abnormality of the central nervous system (CNS), peripheral neuromuscular system, or a combined abnormality involving both. Clinical findings suggestive of an abnormality of the CNS may include hyperreflexia, cognitive developmental delay, and seizures. In contrast, physical findings pointing towards a neuromuscular origin may include weakness, lack of antigravity movements, muscle atrophy, fasciculations, and/or diminished reflexes, most often in the context of normal cognitive function. The HPO term does not distinguish between these etiologies. Additional HPO terms should be used as required to describe associated features." ; rdfs:label "Hypotonia" ; rdfs:subClassOf obo:HP_0003808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001619 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001254 obo:IAO_0000115 "A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating." ; oboInOwl:hasDbXref "MSH:D053609", "SNOMEDCT_US:214264003", "UMLS:C0023380" ; oboInOwl:hasExactSynonym "Lethargy" ; oboInOwl:id "HP:0001254" ; a owl:Class ; rdfs:label "Lethargy" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0001256 obo:IAO_0000115 "Mild intellectual disability is defined as an intelligence quotient (IQ) in the range of 50-69." ; oboInOwl:hasAlternativeId "HP:0006908", "HP:0007119" ; oboInOwl:hasDbXref "SNOMEDCT_US:86765009", "UMLS:C0026106" ; oboInOwl:hasExactSynonym "Intellectual disability, mild", "Mental retardation, borderline-mild", "Mild and nonprogressive mental retardation", "Mild mental retardation" ; oboInOwl:hasRelatedSynonym "Mental retardation, mild" ; oboInOwl:id "HP:0001256" ; a owl:Class ; rdfs:label "Intellectual disability, mild" ; rdfs:subClassOf obo:HP_0001249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001249 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001257 obo:IAO_0000115 "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." ; oboInOwl:hasDbXref "MSH:D009128", "SNOMEDCT_US:221360009", "SNOMEDCT_US:397790002", "UMLS:C0026838" ; oboInOwl:hasExactSynonym "Involuntary muscle stiffness, contraction, or spasm", "Muscle spasticity", "Muscular spasticity" ; oboInOwl:id "HP:0001257" ; a owl:Class ; rdfs:label "Spasticity" ; rdfs:subClassOf obo:HP_0001276, obo:HP_0002493 . obo:HP_0001258 obo:IAO_0000115 "Spasticity and weakness of the leg and hip muscles." ; oboInOwl:hasAlternativeId "HP:0007062", "HP:0007124", "HP:0007216" ; oboInOwl:hasDbXref "MSH:D010264", "SNOMEDCT_US:192967009", "UMLS:C0037772" ; oboInOwl:hasExactSynonym "Spastic paraplegia, lower limb" ; oboInOwl:id "HP:0001258" ; a owl:Class ; rdfs:comment "This phenotypic feature is a major component of the disease hereditary spastic paraplegia, which has multiple distinct genetic etiologies." ; rdfs:label "Spastic paraplegia" ; rdfs:subClassOf obo:HP_0002061, obo:HP_0010550 . obo:HP_0001259 obo:IAO_0000115 "Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli." ; oboInOwl:hasDbXref "ICD-10:R40.2", "MSH:D003128", "SNOMEDCT_US:371632003", "UMLS:C0009421" ; oboInOwl:hasExactSynonym "Coma" ; oboInOwl:id "HP:0001259" ; a owl:Class ; rdfs:comment "Coma is generally a result of diffuse or extensive involvement of both hemispheres of the brain or lesions in the brainstem." ; rdfs:label "Coma" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0001260 obo:IAO_0000115 "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." ; oboInOwl:hasAlternativeId "HP:0002327" ; oboInOwl:hasDbXref "MSH:D004401", "SNOMEDCT_US:8011004", "UMLS:C0013362" ; oboInOwl:hasExactSynonym "Difficulty articulating speech", "Dysarthric speech" ; oboInOwl:id "HP:0001260" ; a owl:Class ; rdfs:label "Dysarthria" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0001262 obo:IAO_0000115 "A state of abnormally strong desire for sleep during the daytime." ; oboInOwl:hasAlternativeId "HP:0002189" ; oboInOwl:hasDbXref "SNOMEDCT_US:271782001", "SNOMEDCT_US:79519003", "UMLS:C2830004" ; oboInOwl:hasExactSynonym "Excessive daytime sleepiness", "More than typical sleepiness during day" ; oboInOwl:id "HP:0001262" ; a owl:Class ; rdfs:label "Excessive daytime somnolence" ; rdfs:subClassOf obo:HP_0002360, obo:HP_0004372 . obo:HP_0001263 obo:IAO_0000115 "A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age." ; oboInOwl:hasAlternativeId "HP:0000754", "HP:0001255", "HP:0001277", "HP:0001292", "HP:0002433", "HP:0002473", "HP:0002532", "HP:0006793", "HP:0006867", "HP:0006885", "HP:0006935", "HP:0007005", "HP:0007094", "HP:0007106", "HP:0007174", "HP:0007224", "HP:0007228", "HP:0007342", "HP:0025356" ; oboInOwl:hasDbXref "SNOMEDCT_US:224958001", "UMLS:C0557874", "UMLS:C1864897", "UMLS:C4020875" ; oboInOwl:hasExactSynonym "Delayed cognitive development", "Delayed development", "Delayed developmental milestones", "Delayed intellectual development", "Delayed milestones", "Delayed psychomotor development", "Developmental delay", "Developmental delay in early childhood", "Developmental delay, global", "Developmental retardation", "Lack of psychomotor development", "Motor and developmental delay", "Motormental retardation", "Psychomotor delay", "Psychomotor development deficiency", "Psychomotor development failure", "Psychomotor developmental delay", "Retarded development", "Retarded mental development", "Retarded psychomotor development" ; oboInOwl:hasRelatedSynonym "Cognitive delay", "Mental and motor retardation" ; oboInOwl:id "HP:0001263" ; a owl:Class ; rdfs:comment "Developmental retardation is any significant lag in development in the any or all of the physical, cognitive, behavioral, emotional, or social spheres. Note that the term intellectual disability (mental retardation) refers to not merely a delay in development but rather a permanent limitation. Note that the term 'psychomotor retardation' is also used in some contexts to refer to a slowing of thought and physical movements as a result of major depression or intoxication." ; rdfs:label "Global developmental delay" ; rdfs:subClassOf obo:HP_0012758 . obo:HP_0001264 obo:IAO_0000115 "Spasticity (neuromuscular hypertonia) primarily in the muscles of the legs, hips, and pelvis." ; oboInOwl:hasDbXref "MSH:D002547", "SNOMEDCT_US:281411007", "UMLS:C0023882" ; oboInOwl:hasExactSynonym "Spastic diparesis", "Spastic diplegic" ; oboInOwl:id "HP:0001264" ; a owl:Class ; rdfs:label "Spastic diplegia" ; rdfs:subClassOf obo:HP_0034353 . obo:HP_0001265 obo:IAO_0000115 "Reduction of neurologic reflexes such as the knee-jerk reaction." ; oboInOwl:hasAlternativeId "HP:0002467" ; oboInOwl:hasDbXref "SNOMEDCT_US:405946002", "UMLS:C0700078" ; oboInOwl:hasExactSynonym "Decreased reflex response", "Decreased reflexes" ; oboInOwl:id "HP:0001265" ; a owl:Class ; rdfs:label "Hyporeflexia" ; rdfs:subClassOf obo:HP_0001315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001266 obo:IAO_0000115 "Involuntary movements characterized by both athetosis (inability to sustain muscles in a fixed position) and chorea (widespread jerky arrhythmic movements)." ; oboInOwl:hasAlternativeId "HP:0002469", "HP:0006811", "HP:0007028", "HP:0007337" ; oboInOwl:hasDbXref "SNOMEDCT_US:43105007", "UMLS:C0085583", "UMLS:C0234967" ; oboInOwl:hasExactSynonym "Choreoathetoid movements" ; oboInOwl:id "HP:0001266" ; a owl:Class ; rdfs:label "Choreoathetosis" ; rdfs:subClassOf obo:HP_0002072, obo:HP_0002305 . obo:HP_0001268 obo:IAO_0000115 "Loss of previously present mental abilities, generally in adults." ; oboInOwl:hasAlternativeId "HP:0002303", "HP:0006822", "HP:0007155", "HP:0007253", "HP:0007264", "HP:0007298" ; oboInOwl:hasDbXref "MSH:D060825", "UMLS:C0234985" ; oboInOwl:hasExactSynonym "Cognitive decline", "Cognitive decline, progressive", "Intellectual deterioration", "Mental deterioration", "Progressive cognitive decline" ; oboInOwl:id "HP:0001268" ; a owl:Class ; rdfs:label "Mental deterioration" ; rdfs:subClassOf obo:HP_0100543 . obo:HP_0001269 obo:IAO_0000115 "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength." ; oboInOwl:hasDbXref "MSH:D010291", "SNOMEDCT_US:127377003", "SNOMEDCT_US:20022000", "UMLS:C0018989" ; oboInOwl:hasExactSynonym "Weakness of one side of body" ; oboInOwl:id "HP:0001269" ; a owl:Class ; rdfs:label "Hemiparesis" ; rdfs:subClassOf obo:HP_0004374 . obo:HP_0001270 obo:IAO_0000115 "A type of Developmental delay characterized by a delay in acquiring motor skills." ; oboInOwl:hasAlternativeId "HP:0001307", "HP:0002130", "HP:0006788", "HP:0006826", "HP:0006909", "HP:0006950", "HP:0006968", "HP:0007219", "HP:0007251" ; oboInOwl:hasDbXref "UMLS:C1854301", "UMLS:C4020874" ; oboInOwl:hasExactSynonym "Delay in motor development", "Delayed early motor milestones", "Delayed motor development", "Delayed motor milestones", "Locomotor delay", "Motor developmental delay", "Motor developmental milestones not achieved", "Motor retardation", "Retarded motor development" ; oboInOwl:hasRelatedSynonym "No development of motor milestones" ; oboInOwl:id "HP:0001270" ; a owl:Class ; rdfs:label "Motor delay" ; rdfs:subClassOf obo:HP_0012758 . obo:HP_0001271 obo:IAO_0000115 "A generalized disorder of peripheral nerves." ; oboInOwl:hasAlternativeId "HP:0006941", "HP:0007287" ; oboInOwl:hasDbXref "MSH:D010523", "MSH:D011115", "SNOMEDCT_US:302226006", "SNOMEDCT_US:42345000", "SNOMEDCT_US:42658009", "UMLS:C0031117", "UMLS:C0152025" ; oboInOwl:hasExactSynonym "Peripheral nerve disease" ; oboInOwl:id "HP:0001271" ; a owl:Class ; rdfs:label "Polyneuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0001272 obo:IAO_0000115 "Cerebellar atrophy is defined as a cerebellum with initially normal structures, in a posterior fossa with normal size, which displays enlarged fissures (interfolial spaces) in comparison to the foliae secondary to loss of tissue. Cerebellar atrophy implies irreversible loss of tissue and result from an ongoing progressive disease until a final stage is reached or a single injury, e.g. an intoxication or infectious event." ; oboInOwl:hasAlternativeId "HP:0002364", "HP:0006839", "HP:0007072", "HP:0007203" ; oboInOwl:hasDbXref "SNOMEDCT_US:95646004", "UMLS:C0262404", "UMLS:C0740279", "UMLS:C4020873" ; oboInOwl:hasExactSynonym "Atrophic cerebellum", "Degeneration of cerebellum" ; oboInOwl:hasRelatedSynonym "Infratentorial atrophy" ; oboInOwl:id "HP:0001272" ; a owl:Class ; rdfs:comment "Cerebellar atrophy can be diagnosed if the cerebellum is small with shrunken folia and large cerebellar fissures or if it has been shown to undergo progressive volume loss." ; rdfs:label "Cerebellar atrophy" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001273 obo:IAO_0000115 "Abnormality of the corpus callosum." ; oboInOwl:hasAlternativeId "HP:0007323" ; oboInOwl:hasDbXref "UMLS:C1842581" ; oboInOwl:hasExactSynonym "Abnormal corpus callosum", "Abnormality of the corpus callosum", "Corpus callosum abnormality" ; oboInOwl:id "HP:0001273" ; a owl:Class ; rdfs:comment "The corpus callosum, a broad thick band of nerve fibers that connects the right and left cerebral hemispheres, is the largest white matter structure in the brain. This finding can be demonstrated by cerebral magenetic resonance tomography. The corpus callosum structurally consists of 4 major anatomic features including the rostrum, genu, corpus, and splenium." ; rdfs:label "Abnormal corpus callosum morphology" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001274 obo:IAO_0000115 "Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." ; oboInOwl:hasAlternativeId "HP:0006800" ; oboInOwl:hasDbXref "Fyler:4321", "MSH:D061085", "SNOMEDCT_US:5102002", "UMLS:C0175754" ; oboInOwl:hasExactSynonym "Absence of corpus callosum", "Absent corpus callosum", "Agenesis of the corpus callosum", "Callosal agenesis", "Corpus callosum agenesis", "Dysplastic or absent corpus callosum" ; oboInOwl:id "HP:0001274" ; a owl:Class ; rdfs:label "Agenesis of corpus callosum" ; rdfs:subClassOf obo:HP_0007370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001276 obo:IAO_0000115 "A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move." ; oboInOwl:hasAlternativeId "HP:0002388" ; oboInOwl:hasDbXref "MSH:D009122", "SNOMEDCT_US:41581000", "SNOMEDCT_US:56731001", "UMLS:C0026826" ; oboInOwl:hasExactSynonym "Hypertonicity", "Increased muscle tone" ; oboInOwl:hasNarrowSynonym "Spasticity and rigidity of muscles" ; oboInOwl:hasRelatedSynonym "Muscle hypertonia" ; oboInOwl:id "HP:0001276" ; a owl:Class ; rdfs:comment "Spasticity is a term that is often used interchangeably with hypertonia. Spasticity, however, is a particular type of hypertonia in which the muscles' spasms are increased by movement. In this type, patients usually have exaggerated reflex responses." ; rdfs:label "Hypertonia" ; rdfs:subClassOf obo:HP_0003808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001618 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001278 obo:IAO_0000115 "A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position." ; oboInOwl:hasAlternativeId "HP:0004932", "HP:0006700" ; oboInOwl:hasDbXref "MSH:D007024", "SNOMEDCT_US:28651003", "UMLS:C0020651" ; oboInOwl:hasExactSynonym "Decrease in blood pressure upon standing up", "Postural hypotension" ; oboInOwl:id "HP:0001278" ; a owl:Class ; rdfs:label "Orthostatic hypotension" ; rdfs:subClassOf obo:HP_0002615, obo:HP_0012332 . obo:HP_0001279 obo:IAO_0000115 "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T10:37:00Z" ; oboInOwl:hasDbXref "MSH:D013575", "SNOMEDCT_US:271594007", "SNOMEDCT_US:272030005", "SNOMEDCT_US:309585006", "UMLS:C0039070" ; oboInOwl:hasExactSynonym "Fainting spell" ; oboInOwl:id "HP:0001279" ; a owl:Class ; rdfs:label "Syncope" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0001281 obo:IAO_0000115 "A condition characterized by intermittent involuntary contraction of muscles (spasms) related to hypocalcemia or occasionally magnesium deficiency." ; oboInOwl:hasDbXref "MSH:D013746", "SNOMEDCT_US:10629009", "UMLS:C0039621" ; oboInOwl:hasExactSynonym "Intermittent involuntary muscle spasm" ; oboInOwl:id "HP:0001281" ; a owl:Class ; rdfs:label "Tetany" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0001283 obo:IAO_0000115 "Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia." ; oboInOwl:hasAlternativeId "HP:0003441", "HP:0003709" ; oboInOwl:hasDbXref "MSH:D010244", "SNOMEDCT_US:398432008", "UMLS:C1301959", "UMLS:C4082299" ; oboInOwl:hasExactSynonym "Bulbar muscle weakness", "Bulbar palsies", "Bulbar weakness" ; oboInOwl:id "HP:0001283" ; a owl:Class ; rdfs:label "Bulbar palsy" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0012638 . obo:HP_0001284 obo:IAO_0000115 "Absence of neurologic reflexes such as the knee-jerk reaction." ; oboInOwl:hasAlternativeId "HP:0001314" ; oboInOwl:hasBroadSynonym "Absent reflexes" ; oboInOwl:hasDbXref "MSH:D012021", "SNOMEDCT_US:349006", "SNOMEDCT_US:37280007", "UMLS:C0234146", "UMLS:C0241772", "UMLS:C0278124" ; oboInOwl:hasExactSynonym "Absent deep tendon reflexes", "Absent tendon reflexes", "Deep tendon reflexes absent", "Loss of deep tendon reflexes" ; oboInOwl:id "HP:0001284" ; a owl:Class ; rdfs:comment "The strectch reflexes (also called deep tendon relfexes) include the knee-jerk reflex (patellar reflex, the biceps reflex, the triceps reflex, and the ankle jerk reflex or Achilles tendon reflex)." ; rdfs:label "Areflexia" ; rdfs:subClassOf obo:HP_0001315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001285 obo:IAO_0000115 "Spastic weakness affecting all four limbs." ; oboInOwl:hasAlternativeId "HP:0002393" ; oboInOwl:hasDbXref "SNOMEDCT_US:298282001", "UMLS:C0575059" ; oboInOwl:hasExactSynonym "Spastic quadriparesis" ; oboInOwl:id "HP:0001285" ; a owl:Class ; rdfs:label "Spastic tetraparesis" ; rdfs:subClassOf obo:HP_0002273, obo:HP_0034353 . obo:HP_0001287 obo:IAO_0000115 "Inflammation of the meninges." ; oboInOwl:hasDbXref "MSH:D008581", "SNOMEDCT_US:7180009", "UMLS:C0025289" ; oboInOwl:id "HP:0001287" ; a owl:Class ; rdfs:label "Meningitis" ; rdfs:subClassOf obo:HP_0011450 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010743 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001288 obo:IAO_0000115 "The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease." ; oboInOwl:hasAlternativeId "HP:0006953" ; oboInOwl:hasDbXref "SNOMEDCT_US:22325002", "UMLS:C0575081" ; oboInOwl:hasExactSynonym "Abnormal gait", "Abnormal walk", "Gait abnormalities", "Gait difficulties", "Gait disturbances", "Impaired gait" ; oboInOwl:id "HP:0001288" ; a owl:Class ; rdfs:comment "If possible, this term should not be used for new annotations. Rather, a more specific term should be sought." ; rdfs:label "Gait disturbance" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0001289 obo:IAO_0000115 "Lack of clarity and coherence of thought, perception, understanding, or action." ; oboInOwl:hasAlternativeId "HP:0000731" ; oboInOwl:hasDbXref "MSH:D003221", "SNOMEDCT_US:286933003", "UMLS:C0009676" ; oboInOwl:hasExactSynonym "Confusion", "Disorientation", "Easily confused", "Mental disorientation" ; oboInOwl:id "HP:0001289" ; a owl:Class ; rdfs:label "Confusion" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0001290 obo:IAO_0000115 "Generalized muscular hypotonia (abnormally low muscle tone)." ; oboInOwl:hasDbXref "UMLS:C1858120" ; oboInOwl:hasExactSynonym "Generalised decreased muscle tone", "Generalised hypotonia", "Generalised muscular hypotonia", "Generalized decreased muscle tone", "Generalized muscular hypotonia", "Hypotonia, generalised", "Hypotonia, generalized" ; oboInOwl:id "HP:0001290" ; a owl:Class ; rdfs:label "Generalized hypotonia" ; rdfs:subClassOf obo:HP_0001252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001619 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0001291 obo:IAO_0000115 "Structural abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem." ; oboInOwl:hasAlternativeId "HP:0003480" ; oboInOwl:hasDbXref "UMLS:C1854510", "UMLS:C4020872" ; oboInOwl:hasExactSynonym "Abnormality of cranial nerve", "Abnormality of the cranial nerves", "Cranial nerve disease", "Cranial nerve involvement" ; oboInOwl:hasRelatedSynonym "Cranial nerve abnormality" ; oboInOwl:id "HP:0001291" ; a owl:Class ; rdfs:label "Abnormal cranial nerve morphology" ; rdfs:subClassOf obo:HP_0000759 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001293 oboInOwl:hasDbXref "SNOMEDCT_US:95664006", "UMLS:C0521670" ; oboInOwl:id "HP:0001293" ; a owl:Class ; rdfs:label "Cranial nerve compression" ; rdfs:subClassOf obo:HP_0001291 . obo:HP_0001297 obo:IAO_0000115 "Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain." ; oboInOwl:hasAlternativeId "HP:0002452" ; oboInOwl:hasDbXref "MSH:D020521", "SNOMEDCT_US:230690007", "UMLS:C0038454" ; oboInOwl:hasExactSynonym "Cerebral vascular events", "Cerebrovascular accident", "Stroke" ; oboInOwl:hasRelatedSynonym "Cerebrovascular accidents" ; oboInOwl:id "HP:0001297" ; a owl:Class ; rdfs:label "Stroke" ; rdfs:subClassOf obo:HP_0100659 . obo:HP_0001298 obo:IAO_0000115 "Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state." ; oboInOwl:hasDbXref "MSH:D001927", "SNOMEDCT_US:81308009", "UMLS:C0085584" ; oboInOwl:id "HP:0001298" ; a owl:Class ; rdfs:comment "This term and its children are general and bundled terms that are kept for convenience. For new annotations, it is recommended that the specific phenotypic abnormalities be noted." ; rdfs:label "Encephalopathy" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001300 obo:IAO_0000115 "Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait." ; oboInOwl:hasDbXref "MSH:D020734", "SNOMEDCT_US:32798002", "UMLS:C0242422" ; oboInOwl:hasRelatedSynonym "Parkinsonian disease" ; oboInOwl:id "HP:0001300" ; a owl:Class ; rdfs:label "Parkinsonism" ; rdfs:subClassOf obo:HP_0002071 . obo:HP_0001301 oboInOwl:hasDbXref "UMLS:C4025794" ; oboInOwl:id "HP:0001301" ; a owl:Class ; rdfs:label "Chronic sensorineural polyneuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0001302 obo:IAO_0000115 "Pachygyria is a malformation of cortical development with abnormally wide gyri with sulci 1,5-3 cm apart and abnormally thick cortex measuring more than 5 mm (radiological definition). See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly." ; oboInOwl:hasDbXref "MSH:D054082", "SNOMEDCT_US:23024003", "UMLS:C0266483" ; oboInOwl:hasExactSynonym "Cerebral pachygyria", "Fewer and broader ridges in brain" ; oboInOwl:id "HP:0001302" ; a owl:Class ; rdfs:label "Pachygyria" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0001304 obo:IAO_0000115 "Sustained involuntary muscle contractions that produce twisting and repetitive movements of the body." ; oboInOwl:hasDbXref "MSH:D004422", "SNOMEDCT_US:22451001", "SNOMEDCT_US:431034009", "UMLS:C0013423" ; oboInOwl:hasExactSynonym "Dystonia musculorum deformans" ; oboInOwl:id "HP:0001304" ; a owl:Class ; rdfs:label "Torsion dystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0001305 obo:IAO_0000115 "A congenital brain malformation typically characterized by incomplete formation of the cerebellar vermis, dilation of the fourth ventricle, and enlargement of the posterior fossa. In layman's terms, Dandy Walker malformation is a cyst in the cerebellum (typically symmetrical) that is involved with the fourth ventricle. This may interfere with the ability to drain cerebrospinal fluid from the brain, resulting in hydrocephalus. Dandy Walker cysts are formed during early embryonic development, while the brain forms. The cyst in the cerebellum typically has several blood vessels running through it connecting to the brain, thereby prohibiting surgical removal." ; oboInOwl:hasAlternativeId "HP:0001313", "HP:0006809" ; oboInOwl:hasDbXref "MSH:D003616", "SNOMEDCT_US:14447001", "UMLS:C0010964" ; oboInOwl:hasExactSynonym "Dandy-Walker cyst", "Dandy-walker anomaly" ; oboInOwl:id "HP:0001305" ; a owl:Class ; rdfs:label "Dandy-Walker malformation" ; rdfs:subClassOf obo:HP_0001320, obo:HP_0002198, obo:HP_0002350, obo:HP_0005445 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008788 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001308 obo:IAO_0000115 "Fasciculations or fibrillation affecting the tongue muscle." ; oboInOwl:hasAlternativeId "HP:0003727" ; oboInOwl:hasDbXref "MSH:D005207", "SNOMEDCT_US:249878001", "UMLS:C0239548" ; oboInOwl:hasExactSynonym "Lingual fasciculations", "Lingual fibrillations", "Lingual twitching", "Tongue fasciculation", "Tongue fasciculations/fibrillations", "Tongue twitching", "Twitching of the tongue" ; oboInOwl:id "HP:0001308" ; a owl:Class ; rdfs:label "Tongue fasciculations" ; rdfs:subClassOf obo:HP_0002380, obo:HP_0010546, obo:HP_0030810 . obo:HP_0001310 obo:IAO_0000115 "A type of ataxia characterized by the inability to carry out movements with the correct range and motion across the plane of more than one joint related to incorrect estimation of the distances required for targeted movements." ; oboInOwl:hasDbXref "MSH:D002524", "SNOMEDCT_US:32566006", "UMLS:C0234162" ; oboInOwl:hasExactSynonym "Lack of coordination of movement" ; oboInOwl:hasRelatedSynonym "Abnormal finger chase test", "Abnormal finger-nose-finger test" ; oboInOwl:id "HP:0001310" ; a owl:Class ; rdfs:comment "Dysmetria can result in moving beyond the target (hypermetria) or failing to reach the target (hypometria) during a voluntary movement. Dysmetria can be assessed clinically by the finger chase test, whereby the examiner and the proband are sitting, and the examiner suddenly moves his or her finger five times in an unpredictable direction in a frontal plane, with movements having an amplitude of about 30 cm and a frequency of once every two seconds. The proband is asked to follow the movements with his or her index finger. The test is abnormal if the proband substantially under- or overshoots or cannot perform pointing movements at all. The finger-nose-finger test is similar, and the proband is asked to alternately touch his or her own nose and then to point to the finger of the examiner." ; rdfs:label "Dysmetria" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0001311 obo:IAO_0000115 "An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations." ; oboInOwl:hasAlternativeId "HP:0002531", "HP:0003129" ; oboInOwl:hasDbXref "UMLS:C4021781" ; oboInOwl:hasExactSynonym "Neurophysiologic abnormalities", "Neurophysiologic abnormality" ; oboInOwl:id "HP:0001311" ; a owl:Class ; rdfs:label "Abnormal nervous system electrophysiology" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001312 obo:IAO_0000115 "An abnormal enlargement (i.e. increase in measured voltage) of somatosensory evoked potentials." ; oboInOwl:hasDbXref "UMLS:C3806961" ; oboInOwl:hasExactSynonym "Giant SEPS" ; oboInOwl:id "HP:0001312" ; a owl:Class ; rdfs:label "Giant somatosensory evoked potentials" ; rdfs:subClassOf obo:HP_0007377 . obo:HP_0001315 obo:IAO_0000115 "Diminution of tendon reflexes, which is an invariable sign of peripheral nerve disease." ; oboInOwl:hasAlternativeId "HP:0001316" ; oboInOwl:hasDbXref "UMLS:C1866934" ; oboInOwl:hasExactSynonym "Absent or decreased deep tendon reflexes", "Decreased deep tendon reflexes", "Decreased tendon reflexes", "Decreased to absent deep tendon reflexes", "Decreased/absent deep tendon reflexes", "Depressed tendon reflexes", "Diminished deep tendon reflexes", "Diminished or absent deep tendon reflexes", "Diminished or absent tendon reflexes", "Hypoactive to absent deep tendon reflexes", "Impaired tendon reflexes", "Reduced/absent deep tendon reflexes", "Weak or absent deep tendon reflexes" ; oboInOwl:id "HP:0001315" ; a owl:Class ; rdfs:comment "The deep tendon reflex is a monosynaptic reflex arc with sensory and motor nerve components, but the arc is much more vulnerable to sensory nerve damage. Ankle plantar flexion is retained in all but the most severe peripheral neuropathies, and thus loss of the Achilles tendon reflex in an objective indication of a substantial sensory nerve defect." ; rdfs:label "Reduced tendon reflexes" ; rdfs:subClassOf obo:HP_0031826 . obo:HP_0001317 obo:IAO_0000115 "Any structural abnormality of the cerebellum." ; oboInOwl:hasDbXref "UMLS:C0742038", "UMLS:C1866129" ; oboInOwl:hasExactSynonym "Abnormality of the cerebellum", "Cerebellar abnormalities", "Cerebellar abnormality", "Cerebellar anomaly", "Cerebellar signs" ; oboInOwl:id "HP:0001317" ; a owl:Class ; rdfs:comment "A malformed cerebellum may be abnormally small, dysplastic, or unusually large. The vermis and both hemispheres may be equally or disproportionately affected. Primary malformations of the pons, midbrain, and supratentorial structures are also seen in a substantial subset of patients. The wide range in morphological presentations results from the diversity of causes, including chromosomal abnormalities, specific genetic syndromes, and extrinsic factors." ; rdfs:label "Abnormal cerebellum morphology" ; rdfs:subClassOf obo:HP_0011283 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001319 obo:IAO_0000115 "Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period." ; oboInOwl:hasAlternativeId "HP:0006830", "HP:0008976" ; oboInOwl:hasDbXref "MSH:D009123", "SNOMEDCT_US:205294008", "UMLS:C2267233" ; oboInOwl:hasExactSynonym "Hypotonia, in neonatal onset", "Hypotonia, neonatal", "Low muscle tone, in neonatal onset" ; oboInOwl:hasRelatedSynonym "Congenital hypotonia" ; oboInOwl:id "HP:0001319" ; a owl:Class ; rdfs:label "Neonatal hypotonia" ; rdfs:subClassOf obo:HP_0001252 . obo:HP_0001320 obo:IAO_0000115 "Underdevelopment of the vermis of cerebellum." ; oboInOwl:hasDbXref "UMLS:C1840379" ; oboInOwl:hasExactSynonym "Cerebellar vermal hypoplasia", "Hypoplasia of the cerebellar vermis", "Hypoplastic cerebellar vermis" ; oboInOwl:id "HP:0001320" ; a owl:Class ; rdfs:label "Cerebellar vermis hypoplasia" ; rdfs:subClassOf obo:HP_0001321, obo:HP_0006817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001321 obo:IAO_0000115 "Cerebellar hypoplasia is a descriptive term implying a cerebellum with a reduced volume, but a normal shape and is stable over time." ; oboInOwl:hasAlternativeId "HP:0006806", "HP:0006910", "HP:0007038", "HP:0007053" ; oboInOwl:hasDbXref "MSH:C562568", "SNOMEDCT_US:16026008", "UMLS:C0266470" ; oboInOwl:hasExactSynonym "Congenital cerebellar hypoplasia", "Hypoplasia of cerebellum", "Hypoplastic cerebellum", "Small cerebellum", "Underdeveloped cerebellum" ; oboInOwl:id "HP:0001321" ; a owl:Class ; rdfs:comment "By prenatal ultrasound, cerebellar hypoplasia is diagnosed if the cerebellum measures more than two standard deviations below the mean. In adults, cerebellar hypoplasia is typically diagnosed by computer tomography or magnetic resonance imaging. Cerebellar hypoplasia can be diagnosed if there is a small cerebellum with fissures of normal size compared with the folia (this is a distinguishing characteristic compared with cerebellar atrophy). Cerebellar hypoplasia (CH) refers to an underdevelopment of the cerebellum. This category of cerebellar malformation is distinct from Dandy Walker malformation in that it does not involve a concurrent enlargement of the posterior fossa, and almost all individuals exhibit cognitive and motor impairments." ; rdfs:label "Cerebellar hypoplasia" ; rdfs:subClassOf obo:HP_0007360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001322 obo:IAO_0100001 "HP:0006872" ; oboInOwl:id "HP:0001322" ; a owl:Class ; rdfs:label "obsolete Brain very small" ; owl:deprecated true . obo:HP_0001324 obo:IAO_0000115 "Reduced strength of muscles." ; oboInOwl:hasAlternativeId "HP:0002309", "HP:0008979", "HP:0009012", "HP:0009061" ; oboInOwl:hasDbXref "MSH:D018908", "SNOMEDCT_US:26544005", "UMLS:C0151786" ; oboInOwl:hasExactSynonym "Muscle weakness", "Muscular weakness" ; oboInOwl:id "HP:0001324" ; a owl:Class ; rdfs:comment "It is important clinical to distinguish between muscle weakness, fatigue, and asthenia. Fatigue describes the inability to continue performing a task after multiple repetitions; in contrast, a patient with primary weakness is unable to perform the first repetition of the task. Asthenia is a sense of weariness or exhaustion in the absence of muscle weakness. Conditions that result in intrinsic muscle weakness can be divided into several main categories: infectious, neurologic, endocrine, inflammatory, rheumatologic, genetic, metabolic, electrolyte-induced, or drug-induced." ; rdfs:label "Muscle weakness" ; rdfs:subClassOf obo:HP_0011804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001325 oboInOwl:hasDbXref "SNOMEDCT_US:267384006", "UMLS:C0020617" ; oboInOwl:hasExactSynonym "Coma caused by low blood sugar", "Coma, hypoglycemic", "Hypoglycaemic coma", "Loss of consciousness due to hypoglycemia" ; oboInOwl:id "HP:0001325" ; a owl:Class ; rdfs:label "Hypoglycemic coma" ; rdfs:subClassOf obo:HP_0001259 . obo:HP_0001326 obo:IAO_0000115 "EEG shows spikes (<80 ms) and waves, which are recorded over the entire scalp and do not have a specific frequency." ; oboInOwl:hasDbXref "UMLS:C4025792" ; oboInOwl:hasExactSynonym "EEG with irregular generalised spike and wave complexes" ; oboInOwl:id "HP:0001326" ; a owl:Class ; rdfs:label "EEG with irregular generalized spike and wave complexes" ; rdfs:subClassOf obo:HP_0010850 . obo:HP_0001327 obo:IAO_0000115 "Generalised myoclonic seizure provoked by flashing or flickering light." ; oboInOwl:hasDbXref "UMLS:C4025791" ; oboInOwl:hasExactSynonym "Photically induced myoclonic seizure", "Photomyoclonic seizure", "Photomyoclonic seizures" ; oboInOwl:id "HP:0001327" ; a owl:Class ; rdfs:label "Photosensitive myoclonic seizure" ; rdfs:subClassOf obo:HP_0002123, obo:HP_0020216 . obo:HP_0001328 obo:IAO_0000115 "Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence." ; oboInOwl:hasAlternativeId "HP:0007234" ; oboInOwl:hasDbXref "UMLS:C4025790" ; oboInOwl:id "HP:0001328" ; a owl:Class ; rdfs:comment "The term learning disability is used with different meanings in different contexts. Significant impairments of mental functioning with a reduction in IQ below 70 should be coded as mental retardation." ; rdfs:label "Specific learning disability" ; rdfs:subClassOf obo:HP_0012759 . obo:HP_0001331 obo:IAO_0000115 "Absence of the septum pellucidum (meaning translucent wall in Latin - SP), also known as the ventricle of Sylvius. The septum pellucidum is a thin, triangular double membrane separating the frontal horns of the right and left lateral ventricles of the brain. It extends between the anterior portion of the corpus callosum, and the body of the fornix and its width varies from 1.5 to 3.0 mm." ; oboInOwl:hasAlternativeId "HP:0006969" ; oboInOwl:hasDbXref "MSH:C535562", "SNOMEDCT_US:253143001", "UMLS:C0431371" ; oboInOwl:hasExactSynonym "Absence of septum pellucidum", "Absence of the septum pellucidum", "Agenesis of the septum pellucidum", "Missing septum pellucidum" ; oboInOwl:id "HP:0001331" ; a owl:Class ; rdfs:comment "In contrast to the septum pellucidum, the cavum septum pellucidum (CSP) is a potential cavity between the membranous leaves of the septum pellucidum, separated by at least 1 mm, and is considered a normal anatomical variation." ; rdfs:label "Absent septum pellucidum" ; rdfs:subClassOf obo:HP_0007375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001332 obo:IAO_0000115 "An abnormally increased muscular tone that causes fixed abnormal postures. There is a slow, intermittent twisting motion that leads to exaggerated turning and posture of the extremities and trunk." ; oboInOwl:hasAlternativeId "HP:0002328" ; oboInOwl:hasDbXref "MSH:D004421", "UMLS:C0013421", "UMLS:C4020871" ; oboInOwl:hasExactSynonym "Dystonic movements" ; oboInOwl:hasRelatedSynonym "Dystonic disease" ; oboInOwl:id "HP:0001332" ; a owl:Class ; rdfs:label "Dystonia" ; rdfs:subClassOf obo:HP_0100022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000598 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001334 obo:IAO_0000115 "A form of hydrocephalus in which there is no visible obstruction to the flow of the cerebrospinal fluid between the ventricles and subarachnoid space." ; oboInOwl:hasDbXref "MSH:D006849", "SNOMEDCT_US:271569006", "UMLS:C0009451" ; oboInOwl:id "HP:0001334" ; a owl:Class ; rdfs:comment "Communicating hydrocephalus may be caused by overproduction of CSF, defective absorption of CSF (the most common cause) or venous drainage insufficiency." ; rdfs:label "Communicating hydrocephalus" ; rdfs:subClassOf obo:HP_0000238 . obo:HP_0001335 obo:IAO_0000115 "Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand." ; oboInOwl:hasDbXref "SNOMEDCT_US:229247004", "UMLS:C0454455" ; oboInOwl:hasExactSynonym "Hand mirror movements", "Mirror hand movements", "Mirror movements" ; oboInOwl:id "HP:0001335" ; a owl:Class ; rdfs:comment "Mirror movement refers to simultaneous contralateral, involuntary, identical movements that accompany voluntary movements. Erlenmeyer first used this term in 1879. The definition of mirror movement as involuntary, synkinetic mirror reversals of an intended movement of opposite side was coined by Cohen et al. in 1991. These movements are soft, neurologic signs, seen uncommonly in clinical practice." ; rdfs:label "Bimanual synkinesia" ; rdfs:subClassOf obo:HP_0034980 . obo:HP_0001336 obo:IAO_0000115 "Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements." ; oboInOwl:hasAlternativeId "HP:0002535", "HP:0007087" ; oboInOwl:hasBroadSynonym "Jerking" ; oboInOwl:hasDbXref "MSH:D009207", "SNOMEDCT_US:127324008", "SNOMEDCT_US:17450006", "UMLS:C0027066", "UMLS:C1854302" ; oboInOwl:hasExactSynonym "Myoclonic jerks" ; oboInOwl:hasRelatedSynonym "Involuntary jerking movements" ; oboInOwl:id "HP:0001336" ; a owl:Class ; rdfs:comment "Myoclonus may be synchronous (several muscle contracting simultaneously), spreading (several muscles contracting in sequence), or asynchronous (several muscles contracting with varying and unpredictable relative timing). Myoclonus is characterized by sudden unidirectional movement due to muscle contraction (positive myoclonus) or due to sudden brief muscle relaxation (negative myoclonus). Electrophysiological tests are very helpful in determining whether myoclonus is cortical, subcortical or spinal." ; rdfs:label "Myoclonus" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 . obo:HP_0001337 obo:IAO_0000115 "An unintentional, oscillating to-and-fro muscle movement about a joint axis." ; oboInOwl:hasAlternativeId "HP:0001295", "HP:0001309" ; oboInOwl:hasDbXref "MSH:D014202", "SNOMEDCT_US:26079004", "UMLS:C0040822" ; oboInOwl:hasExactSynonym "Tremor", "Tremors" ; oboInOwl:id "HP:0001337" ; a owl:Class ; rdfs:comment "Tremor is differentiated from other involuntary movement disorders, such as chorea, athetosis, ballism, tics, and myoclonus, by its repetitive, stereotyped movements of a regular amplitude and frequency. Clonus, unlike tremor, represents a rhythmic movement, which is increased by muscle stretching." ; rdfs:label "Tremor" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000589 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001338 obo:IAO_0000115 "A partial failure of the development of the corpus callosum." ; oboInOwl:hasAlternativeId "HP:0006982", "HP:0007090", "HP:0007128" ; oboInOwl:hasDbXref "MSH:C536111", "SNOMEDCT_US:253140003", "UMLS:C0431368", "UMLS:C1857278" ; oboInOwl:hasExactSynonym "Corpus callosum agenesis, partial", "Partial agenesis of corpus callosum", "Partial corpus callosum agenesis", "Partial or complete agenesis of corpus callosum", "Partial to complete agenesis of corpus callosum", "Partial-total agenesis of corpus callosum" ; oboInOwl:hasRelatedSynonym "Partial or complete agenesis of the corpus callosum" ; oboInOwl:id "HP:0001338" ; a owl:Class ; rdfs:label "Partial agenesis of the corpus callosum" ; rdfs:subClassOf obo:HP_0001274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000297 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0048513 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001339 obo:IAO_0000115 "A spectrum of malformations of cortical development caused by insufficient neuronal migration that subsumes the terms agyria, pachygyria and subcortical band heterotopia. See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly." ; oboInOwl:hasAlternativeId "HP:0002537" ; oboInOwl:hasDbXref "MSH:D054082", "SNOMEDCT_US:204036008", "UMLS:C0266463", "UMLS:C1879312" ; oboInOwl:hasExactSynonym "Fewer or absent grooves in brain" ; oboInOwl:id "HP:0001339" ; a owl:Class ; rdfs:comment "Lissencephaly (LIS, which subsumes the terms agyria and pachygyria), together with subcortical-band heterotopia (SBH) comprises a spectrum of malformations of cortical development caused by insufficient neuronal migration. The key features of LIS are an abnormally thick cortex with reduced or absent formation of the cerebral convolutions, while SBH consists of abnormal bands of neurons beneath a normal cortex, although the cerebral gyri may be separated by unusually shallow sulci." ; rdfs:label "Lissencephaly" ; rdfs:subClassOf obo:HP_0002536 . obo:HP_0001340 obo:IAO_0000115 "Increase in amplitude of a long-loop response upon somatosensory evoked potential testing, representing an electrically evoked myoclonic response." ; oboInOwl:hasDbXref "UMLS:C3552824" ; oboInOwl:id "HP:0001340" ; a owl:Class ; rdfs:label "Enhancement of the C-reflex" ; rdfs:subClassOf obo:HP_0007377 . obo:HP_0001341 oboInOwl:hasDbXref "UMLS:C1855331" ; oboInOwl:hasExactSynonym "Olfactory lobe absence" ; oboInOwl:id "HP:0001341" ; a owl:Class ; rdfs:label "Olfactory lobe agenesis" ; rdfs:subClassOf obo:HP_0025057 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005366 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001342 obo:IAO_0000115 "Hemorrhage into the parenchyma of the brain." ; oboInOwl:hasAlternativeId "HP:0002137" ; oboInOwl:hasDbXref "MSH:D002543", "MSH:D020300", "SNOMEDCT_US:230706003", "SNOMEDCT_US:274100004", "UMLS:C0553692", "UMLS:C2937358" ; oboInOwl:hasExactSynonym "Bleeding in brain", "Cerebral haemorrhage", "Intracerebral haemorrhage", "Intracerebral hemorrhage" ; oboInOwl:hasRelatedSynonym "Hemorrhagic stroke" ; oboInOwl:id "HP:0001342" ; a owl:Class ; rdfs:comment "A cerebral hemorrhage (or intracerebral hemorrhage, ICH), is a type of intracranial hemorrhage that occurs within the brain tissue itself." ; rdfs:label "Cerebral hemorrhage" ; rdfs:subClassOf obo:HP_0002170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001343 obo:IAO_0000115 "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction." ; oboInOwl:hasDbXref "MSH:D007647", "SNOMEDCT_US:50143004", "SNOMEDCT_US:74925009", "UMLS:C0022610" ; oboInOwl:id "HP:0001343" ; a owl:Class ; rdfs:label "Kernicterus" ; rdfs:subClassOf obo:HP_0012443 . obo:HP_0001344 obo:IAO_0000115 "Complete lack of development of speech and language abilities." ; oboInOwl:hasAlternativeId "HP:0001617", "HP:0006798" ; oboInOwl:hasDbXref "UMLS:C0746940", "UMLS:C1854882" ; oboInOwl:hasExactSynonym "Absent speech development", "Lack of language development", "Lack of speech", "No speech development", "No speech or language development", "Nonverbal" ; oboInOwl:id "HP:0001344" ; a owl:Class ; rdfs:comment "This term should not be used in very young children." ; rdfs:label "Absent speech" ; rdfs:subClassOf obo:HP_0000750, obo:HP_0002167 . obo:HP_0001345 oboInOwl:hasDbXref "UMLS:C4025789" ; oboInOwl:id "HP:0001345" ; a owl:Class ; rdfs:label "Psychotic mentation" ; rdfs:subClassOf obo:HP_0000709 . obo:HP_0001347 obo:IAO_0000115 "Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles." ; oboInOwl:hasAlternativeId "HP:0001282", "HP:0006820", "HP:0007184", "HP:0007318" ; oboInOwl:hasDbXref "MSH:D012021", "SNOMEDCT_US:86854008", "UMLS:C0151889" ; oboInOwl:hasExactSynonym "Increased deep tendon reflexes", "Increased reflexes" ; oboInOwl:id "HP:0001347" ; a owl:Class ; rdfs:comment "Reflexes are graded according to the following scale: 0=absent; 1=present but diminished; 2=normoactive; 3=exaggerated; and 4=clonus. Clonus is always abnormal, and a grade 3 reflex may be abnormal if it is asymmetric or if it was previously grade 2 or less." ; rdfs:label "Hyperreflexia" ; rdfs:subClassOf obo:HP_0031826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001348 obo:IAO_0000115 "Tendon reflexes that are noticeably more active than usual (conventionally denoted 3+ on clinical examination). Brisk reflexes may or may not indicate a neurological lesion. They are distinguished from hyperreflexia by the fact that hyerreflexia is characterized by hyperactive repeating (clonic) reflexes, which are considered to be always abnormal." ; oboInOwl:hasDbXref "UMLS:C2673700" ; oboInOwl:hasExactSynonym "Brisk deep tendon reflexes" ; oboInOwl:id "HP:0001348" ; a owl:Class ; rdfs:label "Brisk reflexes" ; rdfs:subClassOf obo:HP_0001347 . obo:HP_0001349 obo:IAO_0000115 "Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy)." ; oboInOwl:hasAlternativeId "HP:0005334", "HP:0007085" ; oboInOwl:hasDbXref "UMLS:C1836003" ; oboInOwl:hasExactSynonym "Bilateral facial weakness", "Facial paresis, bilateral" ; oboInOwl:id "HP:0001349" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Facial diplegia" ; rdfs:subClassOf obo:HP_0010628 . obo:HP_0001350 obo:IAO_0000115 "Abnormal coordination of muscles involved in speech." ; oboInOwl:hasDbXref "SNOMEDCT_US:289195008", "UMLS:C0234518" ; oboInOwl:hasExactSynonym "Slurred speech" ; oboInOwl:id "HP:0001350" ; a owl:Class ; rdfs:label "Slurred speech" ; rdfs:subClassOf obo:HP_0011443 . obo:HP_0001351 obo:IAO_0000115 "Jerk-locked averaging (JLA) is used to record the timing and distribution of brain activity preceding brisk involuntary movements such as those observed in patients with myoclonus. JLA is capable of revealing a premyoclonus spike in the absence of paroxysmal activity in the routine EEG." ; oboInOwl:hasDbXref "UMLS:C3552825" ; oboInOwl:id "HP:0001351" ; a owl:Class ; rdfs:comment "EEG-EMG jerk-locked averaging is a technique that combines EEG and EMG to assess myoclonus. The technique use electromyography (EMG) electrodes for the arms or legs, and correlates averaged EEG responses with EMG bursts used as a trigger." ; rdfs:label "Jerk-locked premyoclonus spikes" ; rdfs:subClassOf obo:HP_0030178 . obo:HP_0001355 obo:IAO_0000115 "Diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia)." ; oboInOwl:hasBroadSynonym "Enlarged brain" ; oboInOwl:hasDbXref "MSH:D058627", "SNOMEDCT_US:19410003", "UMLS:C0221355" ; oboInOwl:hasExactSynonym "Macrencephaly" ; oboInOwl:id "HP:0001355" ; a owl:Class ; rdfs:comment "Megalencephaly is defined as fronto-occipital diameter above two standard deviations of the mean for the patient's age because of an oversized brain parenchyma. This is different from macrocephaly, which is defined by an enlarged head circumference and therefore accounts also for the size of the extra-axial spaces." ; rdfs:label "Megalencephaly" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0001357 obo:IAO_0000115 "Asymmetric head shape, which is usually a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape." ; oboInOwl:hasAlternativeId "HP:0001121" ; oboInOwl:hasBroadSynonym "Asymmetry of the posterior cranium", "Asymmetry of the posterior head", "Asymmetry of the posterior skull", "Flat head", "Rhomboid shaped head" ; oboInOwl:hasDbXref "MSH:D049068", "MSH:D059041", "SNOMEDCT_US:21850008", "SNOMEDCT_US:254024005", "UMLS:C0265529", "UMLS:C1450010", "UMLS:C4072830", "UMLS:C4280597", "UMLS:C4280598", "UMLS:C4280807" ; oboInOwl:hasExactSynonym "Flat head syndrome", "Flattening of cranial vault", "Flattening of cranium", "Flattening of skull", "Rhomboid shaped cranium", "Rhomboid shaped skull" ; oboInOwl:hasNarrowSynonym "Deformational plagiocephaly", "Flattening of head", "Positional plagiocephaly" ; oboInOwl:id "HP:0001357" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Plagiocephaly may affect the posterior skull alone. With plagiocephaly, one can see a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape or asymmetry of the posterior skull alone." ; rdfs:label "Plagiocephaly" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0001360 obo:IAO_0000115 "Holoprosencephaly is a structural anomaly of the brain in which the developing forebrain fails to divide into two separate hemispheres and ventricles." ; oboInOwl:hasAlternativeId "HP:0009807" ; oboInOwl:hasDbXref "Fyler:4338", "MSH:D016142", "SNOMEDCT_US:30915001", "UMLS:C0079541" ; oboInOwl:hasExactSynonym "Single brain ventricle" ; oboInOwl:id "HP:0001360" ; a owl:Class ; rdfs:comment "The presence of a single cerebral ventricle (instead of the usual four) may be seen as part of holoprosencephaly." ; rdfs:label "Holoprosencephaly" ; rdfs:subClassOf obo:HP_0012443 . obo:HP_0001361 obo:IAO_0000115 "Head movements associated with nystagmus, that may represent an attempt to compensate for the involuntary eye movements and to improve vision." ; oboInOwl:hasDbXref "UMLS:C4025788" ; oboInOwl:id "HP:0001361" ; a owl:Class ; rdfs:label "Nystagmus-induced head nodding" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0001362 obo:IAO_0000115 "A localized defect in the bone of the skull resulting from abnormal embryological development. The defect is covered by normal skin. In some cases, skull x-rays have shown underlying lytic bone lesions which have closed before the age of one year." ; oboInOwl:hasDbXref "UMLS:C4025787", "UMLS:C4280595", "UMLS:C4280596" ; oboInOwl:hasExactSynonym "Cranial defect", "Skull defect" ; oboInOwl:hasNarrowSynonym "Calvarial defect" ; oboInOwl:id "HP:0001362" ; a owl:Class ; rdfs:label "Calvarial skull defect" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0001503 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001363 obo:IAO_0000115 "Craniosynostosis refers to the premature closure of the cranial sutures. Primary craniosynostosis refers to the closure of one or more sutures due to abnormalities in skull development, and secondary craniosynostosis results from failure of brain growth." ; oboInOwl:hasAlternativeId "HP:0001365", "HP:0004494", "HP:0005448", "HP:0005457", "HP:0005467", "HP:0008492" ; oboInOwl:hasBroadSynonym "Deformity of the skull" ; oboInOwl:hasDbXref "Fyler:4336", "MSH:D003398", "SNOMEDCT_US:57219006", "UMLS:C0010278", "UMLS:C0235942" ; oboInOwl:hasExactSynonym "Cranial suture synostosis", "Craniosyostosis", "Early fusion of cranial sutures", "Premature closure of cranial sutures", "Premature fontanel closure", "Premature suture closure" ; oboInOwl:hasRelatedSynonym "Craniostenosis" ; oboInOwl:id "HP:0001363" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Skull deformity caused by the premature closure of the cranial sutures. Craniostenosis is a deformity of the skull caused by craniosynostosis, with consequent cessation of skull growth." ; rdfs:label "Craniosynostosis" ; rdfs:subClassOf obo:HP_0002683, obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001367 obo:IAO_0000115 "An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join." ; oboInOwl:hasDbXref "MSH:D007592", "SNOMEDCT_US:399269003", "UMLS:C0022408", "UMLS:C0240083" ; oboInOwl:hasExactSynonym "Abnormal shape of joints", "Abnormality of the joints", "Anomaly of the joints" ; oboInOwl:hasRelatedSynonym "Joint disease" ; oboInOwl:id "HP:0001367" ; a owl:Class ; rdfs:label "Abnormal joint morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001369 obo:IAO_0000115 "Inflammation of a joint." ; oboInOwl:hasDbXref "MSH:D001168", "SNOMEDCT_US:3723001", "UMLS:C0003864" ; oboInOwl:hasExactSynonym "Arthritis", "Joint inflammation" ; oboInOwl:id "HP:0001369" ; a owl:Class ; rdfs:label "Arthritis" ; rdfs:subClassOf obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000982 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001370 obo:IAO_0000115 "Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures." ; oboInOwl:hasDbXref "MSH:D001172", "SNOMEDCT_US:69896004", "UMLS:C0003873" ; oboInOwl:hasExactSynonym "RA", "Rheumatoid arthritis" ; oboInOwl:id "HP:0001370" ; a owl:Class ; rdfs:label "Rheumatoid arthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0001371 obo:IAO_0000115 "A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." ; oboInOwl:hasAlternativeId "HP:0001372", "HP:0001381", "HP:0005053", "HP:0005189", "HP:0005660" ; oboInOwl:hasDbXref "MSH:D003286", "SNOMEDCT_US:203598005", "SNOMEDCT_US:385522000", "SNOMEDCT_US:55033002", "SNOMEDCT_US:57048009", "SNOMEDCT_US:7890003", "SNOMEDCT_US:88565003", "UMLS:C0009917", "UMLS:C0009918", "UMLS:C0333068", "UMLS:C1850530" ; oboInOwl:hasExactSynonym "Flexed joint that cannot be straightened", "Flexion contractures", "Flexion contractures of joints" ; oboInOwl:id "HP:0001371" ; a owl:Class ; rdfs:label "Flexion contracture" ; rdfs:subClassOf obo:HP_0034392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001373 obo:IAO_0000115 "Displacement or malalignment of joints." ; oboInOwl:hasAlternativeId "HP:0002772", "HP:0005837" ; oboInOwl:hasDbXref "MSH:D004204", "SNOMEDCT_US:108367008", "SNOMEDCT_US:87642003", "UMLS:C0012691" ; oboInOwl:hasExactSynonym "Joint dislocation", "Joint dislocations" ; oboInOwl:id "HP:0001373" ; a owl:Class ; rdfs:comment "Dislocation is defined as a complete disruption of the joint and subluxation is defined as a partial dislocation followed by relocation." ; rdfs:label "Joint dislocation" ; rdfs:subClassOf obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001374 oboInOwl:hasDbXref "MSH:D006618", "SNOMEDCT_US:48334007", "SNOMEDCT_US:52781008", "UMLS:C0019555" ; oboInOwl:hasExactSynonym "Congenital dislocation of the hip", "Congenital dislocation of the hips", "Congenital hip anomaly", "Congenital hip dislocations", "Dislocated hip since birth" ; oboInOwl:id "HP:0001374" ; a owl:Class ; rdfs:label "Congenital hip dislocation" ; rdfs:subClassOf obo:HP_0002827 . obo:HP_0001376 obo:IAO_0000115 "A reduction in the freedom of movement of one or more joints." ; oboInOwl:hasAlternativeId "HP:0003101" ; oboInOwl:hasDbXref "UMLS:C1857108" ; oboInOwl:hasExactSynonym "Decreased joint mobility", "Decreased mobility of joints", "Limitation of joint mobility", "Limited joint mobility", "Limited joint motion" ; oboInOwl:id "HP:0001376" ; a owl:Class ; rdfs:label "Limitation of joint mobility" ; rdfs:subClassOf obo:HP_0011729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002283 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001377 obo:IAO_0000115 "Limited ability to straighten the arm at the elbow joint." ; oboInOwl:hasAlternativeId "HP:0005073" ; oboInOwl:hasDbXref "UMLS:C1867103" ; oboInOwl:hasExactSynonym "Decreased elbow extension", "Elbow limited extension", "Limitation of elbow extension", "Limited elbow extension", "Limited extension at elbows", "Limited forearm extension", "Restricted elbow extension" ; oboInOwl:id "HP:0001377" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limited elbow extension" ; rdfs:subClassOf obo:HP_0002996 . obo:HP_0001379 obo:IAO_0100001 "HP:0002758" ; oboInOwl:id "HP:0001379" ; a owl:Class ; rdfs:label "obsolete Degenerative joint disease" ; owl:deprecated true . obo:HP_0001380 obo:IAO_0100001 "HP:0001388" ; oboInOwl:id "HP:0001380" ; a owl:Class ; rdfs:label "obsolete Ligamentous laxity" ; owl:deprecated true . obo:HP_0001382 obo:IAO_0000115 "The ability of a joint to move beyond its normal range of motion." ; oboInOwl:hasAlternativeId "HP:0001378", "HP:0005034" ; oboInOwl:hasDbXref "SNOMEDCT_US:298181000", "UMLS:C1844820" ; oboInOwl:hasExactSynonym "Double-Jointed", "Extensible joints", "Flexible joints", "Hyperextensible joints", "Increased joint mobility", "Increased mobility of joints", "Joint hyperextensibility" ; oboInOwl:id "HP:0001382" ; a owl:Class ; rdfs:label "Joint hypermobility" ; rdfs:subClassOf obo:HP_0011729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001384 obo:IAO_0000115 "An abnormality of the hip joint." ; oboInOwl:hasDbXref "UMLS:C4020870" ; oboInOwl:hasExactSynonym "Abnormality of the hip joint" ; oboInOwl:hasRelatedSynonym "Abnormality of the hip joints" ; oboInOwl:id "HP:0001384" ; a owl:Class ; rdfs:label "Abnormal hip joint morphology" ; rdfs:subClassOf obo:HP_0003272, obo:HP_0100491 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001486 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001385 obo:IAO_0000115 "The presence of developmental dysplasia of the hip." ; oboInOwl:hasAlternativeId "HP:0008787" ; oboInOwl:hasBroadSynonym "Abnormal formation of the hip" ; oboInOwl:hasDbXref "MSH:D006618", "SNOMEDCT_US:48334007", "SNOMEDCT_US:52781008", "UMLS:C0019555" ; oboInOwl:hasExactSynonym "Congenital hip dysplasia" ; oboInOwl:id "HP:0001385" ; a owl:Class ; rdfs:label "Hip dysplasia" ; rdfs:subClassOf obo:HP_0003272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001386 oboInOwl:hasDbXref "SNOMEDCT_US:271771009", "UMLS:C0152031" ; oboInOwl:hasExactSynonym "Joint swelling" ; oboInOwl:id "HP:0001386" ; a owl:Class ; rdfs:label "Joint swelling" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001387 obo:IAO_0000115 "Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time." ; oboInOwl:hasAlternativeId "HP:0002775", "HP:0003033" ; oboInOwl:hasDbXref "SNOMEDCT_US:84445001", "UMLS:C0162298" ; oboInOwl:hasExactSynonym "Joint stiffness", "Stiff joint", "Stiff joints" ; oboInOwl:id "HP:0001387" ; a owl:Class ; rdfs:label "Joint stiffness" ; rdfs:subClassOf obo:HP_0001376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001388 obo:IAO_0000115 "Lack of stability of a joint." ; oboInOwl:hasAlternativeId "HP:0001380", "HP:0001383", "HP:0002771" ; oboInOwl:hasDbXref "MSH:D007593", "SNOMEDCT_US:27911000", "SNOMEDCT_US:298203008", "UMLS:C0086437", "UMLS:C0158359" ; oboInOwl:hasExactSynonym "Hyperlaxity", "Joint instability", "Joint ligamentous laxity", "Lax joints", "Ligamentous laxity", "Loose-jointedness", "Loosejointedness" ; oboInOwl:id "HP:0001388" ; a owl:Class ; rdfs:comment "Joint laxity may be caused by a number of factors including intraarticular disease and injury or slacking of extraarticular structures such as joint capsules, ligaments, and muscles." ; rdfs:label "Joint laxity" ; rdfs:subClassOf obo:HP_0011729 . obo:HP_0001392 obo:IAO_0000115 "An abnormality of the liver." ; oboInOwl:hasDbXref "MSH:D008107", "SNOMEDCT_US:235856003", "UMLS:C0023895", "UMLS:C4021780" ; oboInOwl:hasExactSynonym "Abnormal liver", "Abnormality of the liver", "Liver abnormality" ; oboInOwl:hasRelatedSynonym "Liver disease" ; oboInOwl:id "HP:0001392" ; a owl:Class ; rdfs:label "Abnormality of the liver" ; rdfs:subClassOf obo:HP_0002012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001394 obo:IAO_0000115 "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function." ; oboInOwl:hasDbXref "MSH:D008103", "SNOMEDCT_US:19943007", "UMLS:C0023890" ; oboInOwl:hasExactSynonym "Hepatic cirrhosis", "Scar tissue replaces healthy tissue in the liver" ; oboInOwl:hasRelatedSynonym "Liver cirrhosis" ; oboInOwl:id "HP:0001394" ; a owl:Class ; rdfs:comment "Cirrhosis is caused by chronic liver disease as a result of viral infections (hepatitis), alcohol abuse, certain medications, certain metabolic disorders of iron and copper, and many others. Cirrhosis may lead to a number of abnormalities including hepatomegaly, jaundice, abnormal liver function tests, ascites, dilatation of veins in the abdominal wall, anemia, and clotting deficiencies." ; rdfs:label "Cirrhosis" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0001395 obo:IAO_0000115 "The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process." ; oboInOwl:hasDbXref "MSH:D008103", "SNOMEDCT_US:62484002", "UMLS:C0239946" ; oboInOwl:hasExactSynonym "Liver fibrosis" ; oboInOwl:id "HP:0001395" ; a owl:Class ; rdfs:label "Hepatic fibrosis" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001396 obo:IAO_0000115 "Impairment of bile flow due to obstruction in bile ducts." ; oboInOwl:hasDbXref "MSH:D002779", "SNOMEDCT_US:197446008", "SNOMEDCT_US:30144000", "SNOMEDCT_US:33688009", "UMLS:C0008370" ; oboInOwl:hasExactSynonym "Slowed or blocked flow of bile from liver" ; oboInOwl:id "HP:0001396" ; a owl:Class ; rdfs:label "Cholestasis" ; rdfs:subClassOf obo:HP_0004297 . obo:HP_0001397 obo:IAO_0000115 "Steatosis is a term used to denote lipid accumulation within hepatocytes." ; oboInOwl:hasAlternativeId "HP:0002252", "HP:0200121" ; oboInOwl:hasDbXref "MSH:D005234", "SNOMEDCT_US:197321007", "SNOMEDCT_US:442191002", "UMLS:C2711227" ; oboInOwl:hasExactSynonym "Fatty infiltration of liver", "Fatty liver", "Liver steatosis", "Steatosis" ; oboInOwl:id "HP:0001397" ; a owl:Class ; rdfs:comment "Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes." ; rdfs:label "Hepatic steatosis" ; rdfs:subClassOf obo:HP_0006561 . obo:HP_0001399 oboInOwl:hasDbXref "MSH:D017093", "SNOMEDCT_US:59927004", "UMLS:C0085605" ; oboInOwl:hasExactSynonym "Liver failure" ; oboInOwl:id "HP:0001399" ; a owl:Class ; rdfs:label "Hepatic failure" ; rdfs:subClassOf obo:HP_0001410 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001400 obo:IAO_0100001 "HP:0100523" ; oboInOwl:id "HP:0001400" ; a owl:Class ; rdfs:label "obsolete Hepatic abscesses due to immunodeficiency" ; owl:deprecated true . obo:HP_0001401 oboInOwl:hasDbXref "UMLS:C1859235" ; oboInOwl:id "HP:0001401" ; a owl:Class ; rdfs:label "Intrahepatic biliary dysgenesis" ; rdfs:subClassOf obo:HP_0011040 . obo:HP_0001402 obo:IAO_0000115 "A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver." ; oboInOwl:hasAlternativeId "HP:0002899", "HP:0003007", "HP:0006750" ; oboInOwl:hasDbXref "MSH:D006528", "NCIT:C3099", "SNOMEDCT_US:109841003", "SNOMEDCT_US:187769009", "SNOMEDCT_US:25370001", "UMLS:C1862761", "UMLS:C1867955", "UMLS:C2239176" ; oboInOwl:hasRelatedSynonym "Increased hepatocellular carcinoma risk", "Increased incidence of hepatocellular carcinoma" ; oboInOwl:id "HP:0001402" ; a owl:Class ; rdfs:comment "Hepatocellular carcinoma may be associated with hepatitis B virus infection and cirrhosis or alcoholic cirrhosis." ; rdfs:label "Hepatocellular carcinoma" ; rdfs:subClassOf obo:HP_0002896 . obo:HP_0001403 obo:IAO_0000115 "A form of hepatic steatosis characterized by the presence of large, lipid-laden vesicles in the affected hepatocytes." ; oboInOwl:hasDbXref "UMLS:C1837256" ; oboInOwl:hasExactSynonym "Macrovesicular steatosis" ; oboInOwl:id "HP:0001403" ; a owl:Class ; rdfs:label "Macrovesicular hepatic steatosis" ; rdfs:subClassOf obo:HP_0001397 . obo:HP_0001404 oboInOwl:hasDbXref "UMLS:C1855038" ; oboInOwl:hasExactSynonym "Death of liver cells", "Hepatocellular loss" ; oboInOwl:id "HP:0001404" ; a owl:Class ; rdfs:label "Hepatocellular necrosis" ; rdfs:subClassOf obo:HP_0002605 . obo:HP_0001405 obo:IAO_0000115 "The presence of fibrosis affecting the interlobular stroma of liver." ; oboInOwl:hasDbXref "UMLS:C1849766" ; oboInOwl:id "HP:0001405" ; a owl:Class ; rdfs:comment "Liver fibrosis is not only the result of necrosis, collapse and scar formation but also the result of derangements in the synthesis and degradation of matrix by injured mesenchymal cells." ; rdfs:label "Periportal fibrosis" ; rdfs:subClassOf obo:HP_0001395 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001406 obo:IAO_0000115 "Impairment of bile flow due to obstruction in the small bile ducts within the liver." ; oboInOwl:hasBroadSynonym "Impaired release of bile from liver" ; oboInOwl:hasDbXref "MSH:D002780", "SNOMEDCT_US:4637005", "UMLS:C0008372" ; oboInOwl:id "HP:0001406" ; a owl:Class ; rdfs:label "Intrahepatic cholestasis" ; rdfs:subClassOf obo:HP_0001396, obo:HP_0031865 . obo:HP_0001407 oboInOwl:hasDbXref "SNOMEDCT_US:85057007", "UMLS:C0267834" ; oboInOwl:hasExactSynonym "Liver cysts" ; oboInOwl:id "HP:0001407" ; a owl:Class ; rdfs:label "Hepatic cysts" ; rdfs:subClassOf obo:HP_0006706 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001408 obo:IAO_0000115 "Proliferative changes of the bile ducts." ; oboInOwl:hasDbXref "SNOMEDCT_US:20239009", "UMLS:C0267818" ; oboInOwl:hasExactSynonym "Proliferation of bile canaliculi" ; oboInOwl:id "HP:0001408" ; a owl:Class ; rdfs:label "Bile duct proliferation" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0001409 obo:IAO_0000115 "Increased pressure in the portal vein." ; oboInOwl:hasDbXref "MSH:D006975", "SNOMEDCT_US:34742003", "UMLS:C0020541" ; oboInOwl:id "HP:0001409" ; a owl:Class ; rdfs:comment "Portal hypertension is defined as portal vein pressures exceeding 5 mm Hg or portal vein to hepatic vein gradient of greater than 10 mm Hg." ; rdfs:label "Portal hypertension" ; rdfs:subClassOf obo:HP_0006707, obo:HP_0032263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001576 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001410 obo:IAO_0000115 "Reduced ability of the liver to perform its functions." ; oboInOwl:hasAlternativeId "HP:0004393", "HP:0005228", "HP:0006570" ; oboInOwl:hasDbXref "MSH:D008107", "SNOMEDCT_US:75183008", "SNOMEDCT_US:77981007", "UMLS:C0086565", "UMLS:C0232744", "UMLS:C3279149" ; oboInOwl:hasExactSynonym "Decreased liver function", "Liver dysfunction" ; oboInOwl:hasRelatedSynonym "Hepatopathy", "Liver dysfunction, mild" ; oboInOwl:id "HP:0001410" ; a owl:Class ; rdfs:label "Decreased liver function" ; rdfs:subClassOf obo:HP_0025155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001412 obo:IAO_0000115 "Inflammation of the liver due to infection with enterovirus." ; oboInOwl:hasDbXref "UMLS:C1843995" ; oboInOwl:id "HP:0001412" ; a owl:Class ; rdfs:label "Enteroviral hepatitis" ; rdfs:subClassOf obo:HP_0006562 . obo:HP_0001413 obo:IAO_0000115 "A type of cirrhosis characterized by the presence of small regenerative nodules." ; oboInOwl:hasDbXref "SNOMEDCT_US:21861000", "UMLS:C0267812" ; oboInOwl:id "HP:0001413" ; a owl:Class ; rdfs:comment "In micronodular cirrhosis (Laennec's cirrhosis or portal cirrhosis) regenerating nodules are under 3 mm. This finding can be demonstrated by liver biopsy." ; rdfs:label "Micronodular cirrhosis" ; rdfs:subClassOf obo:HP_0001394 . obo:HP_0001414 obo:IAO_0000115 "A form of hepatic steatosis characterized by the presence of small, lipid-laden vesicles in the affected hepatocytes." ; oboInOwl:hasDbXref "UMLS:C1850415" ; oboInOwl:hasExactSynonym "Microvesicular steatosis" ; oboInOwl:id "HP:0001414" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by liver biopsy." ; rdfs:label "Microvesicular hepatic steatosis" ; rdfs:subClassOf obo:HP_0001397 . obo:HP_0001417 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome." ; oboInOwl:hasAlternativeId "HP:0001418" ; oboInOwl:hasDbXref "MSH:D050172", "SNOMEDCT_US:263934009", "UMLS:C0241764" ; oboInOwl:hasExactSynonym "X-linked", "monoallelic_X_hemizygous" ; oboInOwl:hasRelatedSynonym "X-linked form" ; oboInOwl:id "HP:0001417" ; a owl:Class ; rdfs:label "X-linked inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0001419 obo:IAO_0000115 "A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele." ; oboInOwl:hasDbXref "UMLS:C1845977" ; oboInOwl:hasExactSynonym "X-linked recessive" ; oboInOwl:id "HP:0001419" ; a owl:Class ; rdfs:label "X-linked recessive inheritance" ; rdfs:subClassOf obo:HP_0001417 . obo:HP_0001421 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:59:00Z" ; oboInOwl:hasDbXref "UMLS:C4025786" ; oboInOwl:hasExactSynonym "Abnormal hand muscles" ; oboInOwl:id "HP:0001421" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the hand" ; rdfs:subClassOf obo:HP_0001155, obo:HP_0001446 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001423 obo:IAO_0000115 "A mode of inheritance that is observed for dominant traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked dominant disorders tend to manifest very severely in affected males. The severity of manifestation in females may depend on the degree of skewed X inactivation." ; oboInOwl:hasDbXref "UMLS:C1847879" ; oboInOwl:hasExactSynonym "X-linked dominant" ; oboInOwl:id "HP:0001423" ; a owl:Class ; rdfs:label "X-linked dominant inheritance" ; rdfs:subClassOf obo:HP_0001417 . obo:HP_0001425 obo:IAO_0100001 "HP:0000005" ; oboInOwl:hasExactSynonym "Genetic heterogeneity" ; oboInOwl:id "HP:0001425" ; a owl:Class ; rdfs:label "obsolete Heterogeneous" ; owl:deprecated true . obo:HP_0001426 obo:IAO_0000115 "A mode of inheritance that depends on genetic determinants in more than one gene." ; oboInOwl:hasAlternativeId "HP:0001429", "HP:0001472" ; oboInOwl:hasDbXref "MSH:D020412", "UMLS:C0600599" ; oboInOwl:hasRelatedSynonym "Familial predisposition" ; oboInOwl:id "HP:0001426" ; a owl:Class ; rdfs:comment "The observed inheritance for a multifactorial genetic trait or disorder may have a higher frequency within the same family, whether the etiology is genetic or environmental, or a combination of the two." ; rdfs:label "Non-Mendelian inheritance" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0001427 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy)." ; oboInOwl:hasAlternativeId "HP:0001431", "HP:0001458", "HP:0001506" ; oboInOwl:hasDbXref "MSH:D050259", "UMLS:C0887941" ; oboInOwl:hasExactSynonym "Mitochondrial", "mitochondrial" ; oboInOwl:id "HP:0001427" ; a owl:Class ; rdfs:label "Mitochondrial inheritance" ; rdfs:subClassOf obo:HP_0034345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000005 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001428 obo:IAO_0100001 "HP:0001442" ; oboInOwl:id "HP:0001428" ; a owl:Class ; rdfs:label "obsolete Somatic mutation" ; owl:deprecated true . obo:HP_0001430 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:18:00Z" ; oboInOwl:hasAlternativeId "HP:0004300" ; oboInOwl:hasDbXref "UMLS:C4021779" ; oboInOwl:hasExactSynonym "Abnormal calf muscles", "Abnormality of calf musculature" ; oboInOwl:id "HP:0001430" ; a owl:Class ; rdfs:label "Abnormality of the calf musculature" ; rdfs:subClassOf obo:HP_0001437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004256 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001433 obo:IAO_0000115 "Simultaneous enlargement of the liver and spleen." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T10:51:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:36760000", "UMLS:C0019214" ; oboInOwl:hasExactSynonym "Enlarged liver and spleen" ; oboInOwl:id "HP:0001433" ; a owl:Class ; rdfs:label "Hepatosplenomegaly" ; rdfs:subClassOf obo:HP_0001744, obo:HP_0002240 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0001435 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:19:00Z" ; oboInOwl:hasAlternativeId "HP:0004301" ; oboInOwl:hasDbXref "UMLS:C4021778" ; oboInOwl:hasExactSynonym "Abnormality of shoulder musculature" ; oboInOwl:id "HP:0001435" ; a owl:Class ; rdfs:label "Abnormality of the shoulder girdle musculature" ; rdfs:subClassOf obo:HP_0001446 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001436 obo:IAO_0000115 "An anomaly of the musculature of foot." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:21:00Z" ; oboInOwl:hasDbXref "UMLS:C4025785" ; oboInOwl:hasExactSynonym "Abnormal foot muscles" ; oboInOwl:id "HP:0001436" ; a owl:Class ; rdfs:label "Abnormality of the foot musculature" ; rdfs:subClassOf obo:HP_0001437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001437 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:21:00Z" ; oboInOwl:hasDbXref "UMLS:C4025784" ; oboInOwl:id "HP:0001437" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the lower limbs" ; rdfs:subClassOf obo:HP_0002814, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004482 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001438 obo:IAO_0000115 "A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax." ; oboInOwl:hasDbXref "UMLS:C4020869" ; oboInOwl:hasExactSynonym "Abnormality of abdomen morphology", "Abnormality of abdomen structure", "Abnormality of the abdomen" ; oboInOwl:hasRelatedSynonym "Abdomen abnormality" ; oboInOwl:id "HP:0001438" ; a owl:Class ; rdfs:label "Abnormal abdomen morphology" ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001440 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:36:00Z" ; oboInOwl:hasAlternativeId "HP:0004705", "HP:0008098" ; oboInOwl:hasDbXref "UMLS:C1862697" ; oboInOwl:hasExactSynonym "Fusion of metatarsals", "Fusion of the long bones of the feet", "Synostosis involving metatarsal bones" ; oboInOwl:id "HP:0001440" ; a owl:Class ; rdfs:label "Metatarsal synostosis" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0009140, obo:HP_0100265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001441 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:27:00Z" ; oboInOwl:hasDbXref "UMLS:C4025783" ; oboInOwl:hasExactSynonym "Abnormal thigh muscles" ; oboInOwl:id "HP:0001441" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the thigh" ; rdfs:subClassOf obo:HP_0001437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001442 obo:IAO_0000115 "Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic." ; oboInOwl:hasAlternativeId "HP:0001428", "HP:0001444" ; oboInOwl:hasDbXref "UMLS:C1866227" ; oboInOwl:hasExactSynonym "Autosomal dominant somatic cell mutation", "Somatic mosaicism", "Somatic mutation" ; oboInOwl:id "HP:0001442" ; a owl:Class ; rdfs:comment "A much lower variant allele fraction (VAF) cutoff would be needed in genomic analysis pipelines as compared with the threshold required for consitutional variants." ; rdfs:label "Typified by somatic mosaicism" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0001443 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4025782" ; oboInOwl:hasExactSynonym "Abnormality of glutes" ; oboInOwl:id "HP:0001443" ; a owl:Class ; rdfs:label "Abnormality of the gluteal musculature" ; rdfs:subClassOf obo:HP_0001469 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001444 obo:IAO_0100001 "HP:0001442" ; oboInOwl:id "HP:0001444" ; a owl:Class ; rdfs:label "obsolete Autosomal dominant somatic cell mutation" ; owl:deprecated true . obo:HP_0001445 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4025780" ; oboInOwl:id "HP:0001445" ; a owl:Class ; rdfs:label "Abnormality of the hip-girdle musculature" ; rdfs:subClassOf obo:HP_0001469 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001446 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:40:00Z" ; oboInOwl:hasDbXref "UMLS:C4025779" ; oboInOwl:hasExactSynonym "Abnormal upper limb muscles" ; oboInOwl:id "HP:0001446" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the upper limbs" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001449 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:37:00Z" ; oboInOwl:hasDbXref "UMLS:C4025778" ; oboInOwl:hasExactSynonym "Duplication of long bones of foot" ; oboInOwl:id "HP:0001449" ; a owl:Class ; rdfs:label "Duplication of metatarsal bones" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0009136 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001450 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." ; oboInOwl:hasDbXref "MSH:D050173", "UMLS:C0814045" ; oboInOwl:hasExactSynonym "Y-linked", "monoallelic_Y_hemizygous" ; oboInOwl:id "HP:0001450" ; a owl:Class ; rdfs:label "Y-linked inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0001452 obo:IAO_0100001 "HP:0000006" ; oboInOwl:id "HP:0001452" ; a owl:Class ; rdfs:label "obsolete Autosomal dominant contiguous gene syndrome" ; owl:deprecated true . obo:HP_0001454 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:41:00Z" ; oboInOwl:hasDbXref "UMLS:C4025776" ; oboInOwl:id "HP:0001454" ; a owl:Class ; rdfs:label "Abnormality of the upper arm" ; rdfs:subClassOf obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003822 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001457 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:42:00Z" ; oboInOwl:hasDbXref "UMLS:C4025775" ; oboInOwl:id "HP:0001457" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the upper arm" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0001454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001459 obo:IAO_0000115 "Syndactyly with fusion of toes one to three." ; oboInOwl:hasDbXref "UMLS:C4025774" ; oboInOwl:hasExactSynonym "Webbed 1st-3rd toes" ; oboInOwl:id "HP:0001459" ; a owl:Class ; rdfs:label "1-3 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004691 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001460 obo:IAO_0000115 "Absence or underdevelopment of the musculature." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:46:00Z" ; oboInOwl:hasDbXref "UMLS:C4025773" ; oboInOwl:hasExactSynonym "Absent/small skeletal muscles", "Absent/underdeveloped skeletal muscles" ; oboInOwl:id "HP:0001460" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the skeletal musculature" ; rdfs:subClassOf obo:HP_0030236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001464 obo:IAO_0000115 "Absence or underdevelopment of the muscles of the shoulder." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:49:00Z" ; oboInOwl:hasDbXref "UMLS:C4025772" ; oboInOwl:hasExactSynonym "Absent/small shoulder muscles", "Absent/underdeveloped shoulder muscles" ; oboInOwl:id "HP:0001464" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the shoulder musculature" ; rdfs:subClassOf obo:HP_0001435, obo:HP_0001467 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001465 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:50:00Z" ; oboInOwl:hasDbXref "UMLS:C4025771" ; oboInOwl:hasExactSynonym "Shoulder muscle degeneration", "Wasting of shoulder muscles" ; oboInOwl:id "HP:0001465" ; a owl:Class ; rdfs:label "Amyotrophy involving the shoulder musculature" ; rdfs:subClassOf obo:HP_0001435 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001466 obo:IAO_0000115 "A syndrome caused by the effects of abnormality (typically a deletion or duplication) of 2 or more adjacent genes" ; oboInOwl:hasDbXref "UMLS:C1855496" ; oboInOwl:id "HP:0001466" ; a owl:Class ; rdfs:comment "Examples of contiguous gene synmdromes include Prader-Willi syndrome, Angelman syndrome, and Williams syndrome." ; rdfs:label "Contiguous gene syndrome" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0001467 obo:IAO_0000115 "Absence or underdevelopment of the musculature of the upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:51:00Z" ; oboInOwl:hasDbXref "UMLS:C4025770" ; oboInOwl:hasExactSynonym "Absent/small upper limb muscles", "Absent/underdeveloped upper limb muscles" ; oboInOwl:id "HP:0001467" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the musculature of the upper limbs" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0009128 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001468 obo:IAO_0000115 "Absence or underdevelopment of the muscles of the upper arm." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4025769" ; oboInOwl:hasExactSynonym "Absent/small upper arm muscles", "Absent/underdeveloped upper arm muscles" ; oboInOwl:id "HP:0001468" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the musculature of the upper arm" ; rdfs:subClassOf obo:HP_0001457, obo:HP_0001467 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001469 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:55:00Z" ; oboInOwl:hasDbXref "UMLS:C4025768" ; oboInOwl:hasExactSynonym "Abnormality of the musculature of the pelvis" ; oboInOwl:id "HP:0001469" ; a owl:Class ; rdfs:label "Abnormal morphology of the pelvis musculature" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001470 obo:IAO_0000115 "Sex limitation is used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in one sex." ; oboInOwl:hasDbXref "UMLS:C4025767" ; oboInOwl:id "HP:0001470" ; a owl:Class ; rdfs:label "Sex-limited expression" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0001471 dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:56:00Z" ; oboInOwl:hasDbXref "UMLS:C4025766" ; oboInOwl:hasExactSynonym "Absent/small pelvis muscles", "Absent/underdeveloped pelvis muscles" ; oboInOwl:id "HP:0001471" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the musculature of the pelvis" ; rdfs:subClassOf obo:HP_0001469 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001472 obo:IAO_0100001 "HP:0001426" ; oboInOwl:id "HP:0001472" ; a owl:Class ; rdfs:label "obsolete Familial predisposition" ; owl:deprecated true . obo:HP_0001473 obo:IAO_0000115 "Osteolysis involving metatarsal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:38:00Z" ; oboInOwl:hasAlternativeId "HP:0001866" ; oboInOwl:hasDbXref "UMLS:C1854614" ; oboInOwl:hasExactSynonym "Osteolysis involving metatarsal bones" ; oboInOwl:id "HP:0001473" ; a owl:Class ; rdfs:label "Metatarsal osteolysis" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0009134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002797 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001474 obo:IAO_0000115 "Increased density of the bony tissue of the scapula." ; oboInOwl:hasDbXref "UMLS:C1849263" ; oboInOwl:id "HP:0001474" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sclerotic scapulae" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001475 obo:IAO_0000115 "Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the male sex." ; oboInOwl:hasDbXref "UMLS:C4025764" ; oboInOwl:id "HP:0001475" ; a owl:Class ; rdfs:label "Male-limited expression" ; rdfs:subClassOf obo:HP_0001470 . obo:HP_0001476 obo:IAO_0000115 "A delay in closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life." ; oboInOwl:hasBroadSynonym "Delayed closure of the soft spot on the skull", "Late closure of soft spot on the skull" ; oboInOwl:hasDbXref "SNOMEDCT_US:295091000119100", "UMLS:C3840083", "UMLS:C4072831" ; oboInOwl:hasExactSynonym "Delayed closure anterior fontanel", "Delayed closure of anterior fontanelle", "Delayed closure of the bregma sutures", "Late closure of anterior fontanelle", "Late closure of large anterior fontanel", "Late closure of the bregma sutures", "Later than typical closing of soft spot of skull", "Persistent anterior fontanelle" ; oboInOwl:id "HP:0001476" ; a owl:Class ; rdfs:label "Delayed closure of the anterior fontanelle" ; rdfs:subClassOf obo:HP_0000236, obo:HP_0000270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002135 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001477 obo:IAO_0000115 "A tendency to hold the chin elevated by about 20 to 30 degrees to compensate for a limitation of eye movement." ; oboInOwl:hasDbXref "UMLS:C1846911" ; oboInOwl:hasExactSynonym "Compensatory head tilt/chin elevation" ; oboInOwl:id "HP:0001477" ; a owl:Class ; rdfs:label "Compensatory chin elevation" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0001480 obo:IAO_0000115 "The presence of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin." ; oboInOwl:hasDbXref "MSH:D008548", "SNOMEDCT_US:403536009", "SNOMEDCT_US:699225003", "UMLS:C0016689" ; oboInOwl:hasExactSynonym "Freckling" ; oboInOwl:id "HP:0001480" ; a owl:Class ; rdfs:label "Freckling" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0001482 obo:IAO_0000115 "Slightly elevated lesions on or in the skin with a diameter of over 5 mm." ; oboInOwl:hasAlternativeId "HP:0005903" ; oboInOwl:hasBroadSynonym "Nodule below the skin" ; oboInOwl:hasDbXref "SNOMEDCT_US:95325000", "UMLS:C0151811", "UMLS:C0746926" ; oboInOwl:hasExactSynonym "Firm lump under the skin", "Growth of abnormal tissue under the skin" ; oboInOwl:hasRelatedSynonym "Multiple, subcutaneous nodules", "Subcutaneous nodules" ; oboInOwl:id "HP:0001482" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Subcutaneous nodules may move freely within the dermis or may be fixed to skin above or subcutaneous tissue below." ; rdfs:label "Subcutaneous nodule" ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0001483 obo:IAO_0000115 "Repetitive pressing, poking, and/or rubbing in the eyes." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:78894008", "UMLS:C0233593" ; oboInOwl:hasExactSynonym "Blindism", "Eye pressing", "Ocular auto-stimulation", "Oculodigital phenomenon" ; oboInOwl:id "HP:0001483" ; a owl:Class ; rdfs:comment "Eye poking is usually observed in children with an intellectual and visual handicap." ; rdfs:label "Eye poking" ; rdfs:subClassOf obo:HP_0100716, obo:HP_5200017, obo:HP_5200065 . obo:HP_0001487 obo:IAO_0100001 "HP:0007894" ; oboInOwl:id "HP:0001487" ; a owl:Class ; rdfs:label "obsolete Hypopigmented fundi" ; owl:deprecated true . obo:HP_0001488 oboInOwl:hasDbXref "UMLS:C1865916" ; oboInOwl:hasExactSynonym "Drooping of both upper eyelids" ; oboInOwl:id "HP:0001488" ; a owl:Class ; rdfs:label "Bilateral ptosis" ; rdfs:subClassOf obo:HP_0000508 . obo:HP_0001489 obo:IAO_0000115 "Separation of the vitreous humor from the retina." ; oboInOwl:hasDbXref "MSH:D020255", "SNOMEDCT_US:247081001", "UMLS:C0423361" ; oboInOwl:hasExactSynonym "Vitreous detachment" ; oboInOwl:id "HP:0001489" ; a owl:Class ; rdfs:comment "The vitreous humour is a transparent and colorless gel located between the retina and the lens. In posterior vitreous detachment (PVD), the vitreous membrane (which surrounds the vitreous humor) separates from the retina. This condition is common in individuals over 65 years of age but may occur in younger persons. PVD is often characterized by flashes of light and floaters, and may be complicated by retinal detachment." ; rdfs:label "Posterior vitreous detachment" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0001491 obo:IAO_0000115 "Congenital non-progressive ophthalmoplegia with multiple extraocular muscle restrictions. Typically, there is ptosis and variable degrees of restriction of horizontal and vertical eye movements." ; oboInOwl:hasDbXref "MSH:C580012", "SNOMEDCT_US:400946004", "UMLS:C1302995" ; oboInOwl:hasExactSynonym "CFEOM", "Congenital fibrosis of the extraocular muscles", "Congenital ophthalmoplegia" ; oboInOwl:id "HP:0001491" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Congenital fibrosis of extraocular muscles" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001492 obo:IAO_0000115 "Axenfeld's anomaly is a bilateral disorder characterized by a prominent, anteriorly displaced Schwalbe's line (posterior embryotoxon) and peripheral iris strands which span the anterior chamber angle to attach to Schwalbe's line." ; oboInOwl:hasDbXref "MSH:C535679", "SNOMEDCT_US:204152008", "UMLS:C0266548" ; oboInOwl:id "HP:0001492" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Axenfeld anomaly" ; rdfs:subClassOf obo:HP_0007700 . obo:HP_0001493 obo:IAO_0000115 "An area of the retina that is buckled so that a sector-shaped sheet of retina lies in front of the normal retina. This feature is of congenital onset." ; oboInOwl:hasAlternativeId "HP:0008013" ; oboInOwl:hasDbXref "SNOMEDCT_US:204181009", "UMLS:C0344550" ; oboInOwl:hasExactSynonym "Congenital retinal fold" ; oboInOwl:id "HP:0001493" ; a owl:Class ; rdfs:label "Falciform retinal fold" ; rdfs:subClassOf obo:HP_0008052 . obo:HP_0001495 obo:IAO_0000115 "Osteolysis affecting carpal bones." ; oboInOwl:hasDbXref "UMLS:C1833734" ; oboInOwl:hasExactSynonym "Carpal bone osteolysis" ; oboInOwl:id "HP:0001495" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Carpal osteolysis" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0045039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001498 obo:IAO_0000115 "Underdevelopment of one or more carpal bones." ; oboInOwl:hasAlternativeId "HP:0001209", "HP:0006029", "HP:0006072", "HP:0006117", "HP:0006130", "HP:0006227" ; oboInOwl:hasBroadSynonym "Small wrist bones" ; oboInOwl:hasDbXref "UMLS:C1863749", "UMLS:C4280594" ; oboInOwl:hasExactSynonym "Hypoplasia of carpal bones", "Hypoplastic carpal bones", "Small carpal bones", "Small carpals" ; oboInOwl:id "HP:0001498" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Carpal bone hypoplasia" ; rdfs:subClassOf obo:HP_0006502 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001500 obo:IAO_0000115 "Increased width of a non-thumb digit of the hand." ; oboInOwl:hasAlternativeId "HP:0001497" ; oboInOwl:hasDbXref "UMLS:C1844906" ; oboInOwl:hasExactSynonym "Broad finger", "Broad fingers", "Wide fingers" ; oboInOwl:id "HP:0001500" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that the girth may be increased in a broad finger, but this must be distinguished from Macrodactyly, because there the length is also increased. This distinction can be subtle. This term should not be used when the increased width is limited to the distal phalanges, instead use Broad fingertips. The affected digit should be specified by the numbering scheme in the introduction. This term is not used for the first digit, see Broad thumbs. When a thumb and one or more fingers are affected, it may be more economical to specify \"Broad fingers, F1-5\" instead of separately specifying \"Broad thumb\" and \"Broad fingers F2-5\"." ; rdfs:label "Broad finger" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001501 oboInOwl:hasDbXref "UMLS:C1861360" ; oboInOwl:hasExactSynonym "6 long bones of hand" ; oboInOwl:id "HP:0001501" ; a owl:Class ; rdfs:label "6 metacarpals" ; rdfs:subClassOf obo:HP_0005917 . obo:HP_0001504 oboInOwl:hasDbXref "UMLS:C1854610" ; oboInOwl:hasExactSynonym "Metacarpals osteolysis" ; oboInOwl:id "HP:0001504" ; a owl:Class ; rdfs:label "Metacarpal osteolysis" ; rdfs:subClassOf obo:HP_0005916, obo:HP_0045039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001507 oboInOwl:hasAlternativeId "HP:0008904" ; oboInOwl:hasDbXref "UMLS:C0262361" ; oboInOwl:hasExactSynonym "Abnormal growth", "Growth abnormality", "Growth issue" ; oboInOwl:id "HP:0001507" ; a owl:Class ; rdfs:label "Growth abnormality" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0040007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001508 obo:IAO_0000115 "Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm." ; oboInOwl:hasAlternativeId "HP:0001535", "HP:0008853", "HP:0008878", "HP:0008916" ; oboInOwl:hasBroadSynonym "Undergrowth" ; oboInOwl:hasDbXref "SNOMEDCT_US:36440009", "SNOMEDCT_US:432788009", "UMLS:C0231246", "UMLS:C2315100" ; oboInOwl:hasExactSynonym "Faltering weight", "Postnatal failure to thrive", "Weight faltering" ; oboInOwl:hasRelatedSynonym "Poor weight gain" ; oboInOwl:id "HP:0001508" ; a owl:Class ; rdfs:comment "Although there is no clear consensus on the exact definition of FTT, it is usually diagnoses in a child growing below the 3rd percentile or in a child whose decreased growth has cross two major growth percentiles (for example, from above the 75th percentile to below the 25th percentile)." ; rdfs:label "Failure to thrive" ; rdfs:subClassOf obo:HP_0004325 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0040007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001510 obo:IAO_0000115 "A deficiency or slowing down of growth pre- and postnatally." ; oboInOwl:hasAlternativeId "HP:0001434", "HP:0001512", "HP:0001514", "HP:0001517", "HP:0001532", "HP:0008847", "HP:0008870", "HP:0008886", "HP:0008893", "HP:0008926" ; oboInOwl:hasDbXref "SNOMEDCT_US:276617005", "SNOMEDCT_US:444896005", "SNOMEDCT_US:59576002", "UMLS:C0151686", "UMLS:C0456070", "UMLS:C0878787", "UMLS:C1837385", "UMLS:C3552463" ; oboInOwl:hasExactSynonym "Delayed growth", "Growth deficiency", "Growth delay", "Growth failure", "Growth retardation", "Poor growth", "Retarded growth" ; oboInOwl:hasRelatedSynonym "Very poor growth" ; oboInOwl:id "HP:0001510" ; a owl:Class ; rdfs:comment "Poor or abnormally slow gains in weight or height in a child." ; rdfs:label "Growth delay" ; rdfs:subClassOf obo:HP_0001507 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0040007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001511 obo:IAO_0000115 "An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age." ; oboInOwl:hasAlternativeId "HP:0001515", "HP:0008862", "HP:0008892", "HP:0008931" ; oboInOwl:hasDbXref "MSH:D005317", "MSH:D007236", "SNOMEDCT_US:199612005", "SNOMEDCT_US:22033007", "UMLS:C0015934", "UMLS:C0021296", "UMLS:C1386048" ; oboInOwl:hasExactSynonym "IUGR", "In utero growth retardation", "Intrauterine growth failure", "Intrauterine growth restriction", "Intrauterine growth retardation, IUGR", "Intrauterine retardation", "Prenatal growth deficiency", "Prenatal growth failure", "Prenatal growth retardation", "Prenatal onset growth retardation", "Prenatal-onset growth retardation", "Small for gestational age infant" ; oboInOwl:id "HP:0001511" ; a owl:Class ; rdfs:comment "Intrauterine growth restriction is a newer term that is preferred over Intrauterine growth retardation. The causes of IUGR include maternal abnormalities (chronic hypertension, cyanotic heart disease, smoking, drug abuse), placental or umbilical cord abnormalities (including placenta previa and cord anomalies), maternal medicationas, and genetic disorders of the fetus." ; rdfs:label "Intrauterine growth retardation" ; rdfs:subClassOf obo:HP_0001510 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009790 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001513 obo:IAO_0000115 "Accumulation of substantial excess body fat." ; oboInOwl:hasDbXref "MSH:D009765", "SNOMEDCT_US:414915002", "SNOMEDCT_US:414916001", "UMLS:C0028754" ; oboInOwl:hasExactSynonym "Having too much body fat", "Obesity" ; oboInOwl:id "HP:0001513" ; a owl:Class ; rdfs:label "Obesity" ; rdfs:subClassOf obo:HP_0004324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001518 obo:IAO_0000115 "Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age." ; oboInOwl:hasAlternativeId "HP:0001422", "HP:0008849", "HP:0008919", "HP:0008927" ; oboInOwl:hasDbXref "MSH:D007230", "SNOMEDCT_US:267258002", "SNOMEDCT_US:276610007", "UMLS:C0024032", "UMLS:C0235991" ; oboInOwl:hasExactSynonym "Birth weight less than 10th percentile", "Low birth weight", "Small for gestational age" ; oboInOwl:id "HP:0001518" ; a owl:Class ; rdfs:label "Small for gestational age" ; rdfs:subClassOf obo:HP_0004325 . obo:HP_0001519 obo:IAO_0000115 "A tall and slim body build with increased arm span to height ratio (>1.05) and a reduced upper-to-lower segment ratio (<0.85), i.e., unusually long arms and legs. The extremities as well as the hands and feet are unusually slim." ; oboInOwl:hasAlternativeId "HP:0003511", "HP:0008864" ; oboInOwl:hasDbXref "MSH:D054119", "SNOMEDCT_US:62250003", "UMLS:C0003706", "UMLS:C1836996" ; oboInOwl:hasExactSynonym "Dolichostenomelia", "Marfanoid body habitus", "Marfanoid habitus", "Reduced upper-lower segment ratio" ; oboInOwl:id "HP:0001519" ; a owl:Class ; rdfs:label "Disproportionate tall stature" ; rdfs:subClassOf obo:HP_0000098 . obo:HP_0001520 obo:IAO_0000115 "The term large for gestational age applies to babies whose birth weight lies above the 90th percentile for that gestational age." ; oboInOwl:hasAlternativeId "HP:0001825" ; oboInOwl:hasDbXref "UMLS:C1848395" ; oboInOwl:hasExactSynonym "Birth weight > 90th percentile", "Birthweight > 90th percentile", "Fetal macrosomia", "Foetal macrosomia", "Macrosomia", "Macrosomia, neonatal" ; oboInOwl:id "HP:0001520" ; a owl:Class ; rdfs:comment "Fetal macrosomia has been defined in several different ways, including birth weight of 4000-4500 g (8 lb 13 oz to 9 lb 15 oz) or greater than 90% for gestational age after correcting for neonatal sex and ethnicity. Based on these definitions, macrosomia affects 1-10% of all pregnancies. A diagnosis of fetal macrosomia can be made only by measuring birth weight after delivery; therefore, the condition is confirmed only retrospectively, ie, after delivery of the neonate." ; rdfs:label "Large for gestational age" ; rdfs:subClassOf obo:HP_0004324 . obo:HP_0001522 obo:IAO_0000115 "Death within the first 24 months of life." ; oboInOwl:hasAlternativeId "HP:0003816", "HP:0003817", "HP:0003818", "HP:0003823", "HP:0003827" ; oboInOwl:hasDbXref "UMLS:C1844947", "UMLS:C1858430" ; oboInOwl:hasExactSynonym "Death in infancy", "Infantile death", "Lethal in infancy" ; oboInOwl:hasRelatedSynonym "Death in early childhood" ; oboInOwl:id "HP:0001522" ; a owl:Class ; rdfs:label "Death in infancy" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0001525 oboInOwl:hasAlternativeId "HP:0008876" ; oboInOwl:hasDbXref "UMLS:C1855514" ; oboInOwl:hasExactSynonym "Marked failure to thrive", "Severe faltering weight", "Severe postnatal failure to thrive", "Severe weight faltering" ; oboInOwl:id "HP:0001525" ; a owl:Class ; rdfs:label "Severe failure to thrive" ; rdfs:subClassOf obo:HP_0001508 . obo:HP_0001528 obo:IAO_0000115 "Overgrowth of only one side of the body." ; oboInOwl:hasAlternativeId "HP:0006416" ; oboInOwl:hasDbXref "SNOMEDCT_US:205838004", "SNOMEDCT_US:56007004", "UMLS:C0332890" ; oboInOwl:hasExactSynonym "Asymmetric limb hypertrophy", "Asymmetric overgrowth" ; oboInOwl:id "HP:0001528" ; a owl:Class ; rdfs:label "Hemihypertrophy" ; rdfs:subClassOf obo:HP_0040064, obo:HP_0100555 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0001530 obo:IAO_0000115 "A mild degree of slow or limited growth after birth, being between two and three standard deviations below age- and sex-related norms." ; oboInOwl:hasAlternativeId "HP:0008860", "HP:0008917" ; oboInOwl:hasDbXref "UMLS:C1835580", "UMLS:C3550204" ; oboInOwl:hasExactSynonym "Postnatal onset of mild growth retardation" ; oboInOwl:hasRelatedSynonym "Mild growth deficiency" ; oboInOwl:id "HP:0001530" ; a owl:Class ; rdfs:label "Mild postnatal growth retardation" ; rdfs:subClassOf obo:HP_0008897 . obo:HP_0001531 oboInOwl:hasAlternativeId "HP:0008863", "HP:0008925" ; oboInOwl:hasDbXref "UMLS:C1867873" ; oboInOwl:hasExactSynonym "Failure to thrive in first year of life", "Faltering weight in infancy", "Weight faltering in infancy" ; oboInOwl:id "HP:0001531" ; a owl:Class ; rdfs:label "Failure to thrive in infancy" ; rdfs:subClassOf obo:HP_0001508 . obo:HP_0001533 obo:IAO_0000115 "Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones." ; oboInOwl:hasAlternativeId "HP:0001529" ; oboInOwl:hasDbXref "UMLS:C1850573" ; oboInOwl:hasExactSynonym "Asthenic habitus", "Slender build", "Thin body habitus", "Thin build" ; oboInOwl:id "HP:0001533" ; a owl:Class ; rdfs:comment "Slender, long-limbed habitus." ; rdfs:label "Slender build" ; rdfs:subClassOf obo:HP_0000098, obo:HP_0004325 . obo:HP_0001537 obo:IAO_0000115 "Protrusion of abdominal contents through a defect in the abdominal wall musculature around the umbilicus. Skin and subcutaneous tissue overlie the defect." ; oboInOwl:hasDbXref "Fyler:4445", "SNOMEDCT_US:396347007", "UMLS:C0019322" ; oboInOwl:hasExactSynonym "Umbilical hernias" ; oboInOwl:id "HP:0001537" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Umbilical hernia" ; rdfs:subClassOf obo:HP_0001551, obo:HP_0004299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002163 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0017672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0007118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001538 obo:IAO_0000115 "A thrusting or bulging out of the abdomen." ; oboInOwl:hasDbXref "UMLS:C1854928" ; oboInOwl:hasExactSynonym "Abdominal protuberance", "Belly sticks out", "Extended belly" ; oboInOwl:id "HP:0001538" ; a owl:Class ; rdfs:label "Protuberant abdomen" ; rdfs:subClassOf obo:HP_0003270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001539 obo:IAO_0000115 "A midline anterior incomplete closure of the abdominal wall in which there is herniation of the abdominal viscera into the base of the abdominal cord." ; oboInOwl:hasDbXref "Fyler:4404", "MEDDRA:10030309", "MSH:D006554", "SNOMEDCT_US:18735004", "UMLS:C0795690" ; oboInOwl:hasExactSynonym "Exomphalos", "Omphalocoele" ; oboInOwl:id "HP:0001539" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Omphalocele" ; rdfs:subClassOf obo:HP_0004299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000643 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001540 obo:IAO_0000115 "A separation of the rectus abdominis muscle into right and left halves (which are normally joined at the midline at the linea alba)." ; oboInOwl:hasDbXref "SNOMEDCT_US:62629000", "UMLS:C0221766" ; oboInOwl:hasExactSynonym "Gap between large left and right abdominal muscles" ; oboInOwl:id "HP:0001540" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Diastasis recti looks like a ridge, which runs down the middle of the abdomen and increases with muscle straining. Diastasis recti is not uncommon in pregnant women and is common and normal in newborns." ; rdfs:label "Diastasis recti" ; rdfs:subClassOf obo:HP_0010991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001541 obo:IAO_0000115 "Accumulation of fluid in the peritoneal cavity." ; oboInOwl:hasDbXref "MSH:D001201", "SNOMEDCT_US:389026000", "UMLS:C0003962" ; oboInOwl:hasExactSynonym "Accumulation of fluid in the abdomen" ; oboInOwl:id "HP:0001541" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Ascites is commonly associated with liver disease that has resulted in portal hypertension and low serum albumin levels." ; rdfs:label "Ascites" ; rdfs:subClassOf obo:HP_0001438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000913 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001543 obo:IAO_0000115 "A type of congenital ventral incomplete closure of the abdominal wall in which the intestines and sometimes other organs extend freely into the amniotic fluid space through a small opening in the abdomen, usually to the right of the umbilicus." ; oboInOwl:hasDbXref "MEDDRA:10018046", "MSH:D020139", "SNOMEDCT_US:72951007", "UMLS:C0265706" ; oboInOwl:id "HP:0001543" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gastroschisis" ; rdfs:subClassOf obo:HP_0010866 . obo:HP_0001544 obo:IAO_0000115 "Abnormally prominent umbilicus (belly button)." ; oboInOwl:hasDbXref "UMLS:C1837795" ; oboInOwl:hasExactSynonym "Prominent belly button", "Prominent navel" ; oboInOwl:id "HP:0001544" ; a owl:Class ; rdfs:label "Prominent umbilicus" ; rdfs:subClassOf obo:HP_0001551 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001545 obo:IAO_0000115 "Anterior malposition of the anus." ; oboInOwl:hasDbXref "UMLS:C1838705" ; oboInOwl:hasExactSynonym "Anteriorly displaced anus", "Anus anteposition" ; oboInOwl:id "HP:0001545" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anteriorly placed anus" ; rdfs:subClassOf obo:HP_0004397 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001921 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001547 obo:IAO_0000115 "A morphological anomaly of the rib cage." ; oboInOwl:hasDbXref "UMLS:C4025763" ; oboInOwl:hasExactSynonym "Abnormality of the rib cage" ; oboInOwl:id "HP:0001547" ; a owl:Class ; rdfs:label "Abnormal rib cage morphology" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001548 obo:IAO_0000115 "Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference." ; oboInOwl:hasDbXref "UMLS:C1849265", "UMLS:C1851731", "UMLS:C3150281" ; oboInOwl:hasExactSynonym "General overgrowth" ; oboInOwl:hasRelatedSynonym "Generalised overgrowth", "Generalized overgrowth" ; oboInOwl:id "HP:0001548" ; a owl:Class ; rdfs:label "Overgrowth" ; rdfs:subClassOf obo:HP_0000098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000098 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000256 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001549 dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:05:00Z" ; oboInOwl:hasDbXref "UMLS:C4025762" ; oboInOwl:hasExactSynonym "Abnormality of the ileum" ; oboInOwl:id "HP:0001549" ; a owl:Class ; rdfs:label "Abnormal ileum morphology" ; rdfs:subClassOf obo:HP_0002244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001551 obo:IAO_0000115 "An abnormality of the structure or appearance of the umbilicus." ; oboInOwl:hasDbXref "UMLS:C1849338" ; oboInOwl:hasExactSynonym "Abnormal belly button", "Abnormal navel", "Abnormal umbilicus" ; oboInOwl:id "HP:0001551" ; a owl:Class ; rdfs:comment "The umbilicus is also known as the belly button or the navel." ; rdfs:label "Abnormal umbilicus morphology" ; rdfs:subClassOf obo:HP_0004298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001552 obo:IAO_0000115 "A rounded, bulging chest that resembles the shape of a barrel. That is, there is an increased anteroposterior diameter and usually some degree of kyphosis." ; oboInOwl:hasAlternativeId "HP:0000781", "HP:0001553" ; oboInOwl:hasDbXref "SNOMEDCT_US:24228002", "UMLS:C0264172" ; oboInOwl:hasExactSynonym "Barrel chest", "Barrel-shaped chest" ; oboInOwl:id "HP:0001552" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Barrel chest is often seen in persons with pulmonary emphysema or chronic obstructive pulmonary disease." ; rdfs:label "Barrel-shaped chest" ; rdfs:subClassOf obo:HP_0100625 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001898 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016416 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001555 obo:IAO_0000115 "Lack of symmetry between the left and right halves of the thorax." ; oboInOwl:hasDbXref "UMLS:C1858033" ; oboInOwl:hasExactSynonym "Asymmetric chest" ; oboInOwl:id "HP:0001555" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the thorax" ; rdfs:subClassOf obo:HP_0001547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001557 obo:IAO_0000115 "An abnormality of fetal movement." ; oboInOwl:hasAlternativeId "HP:0007629" ; oboInOwl:hasDbXref "UMLS:C1849510" ; oboInOwl:hasExactSynonym "Abnormal intrauterine movements" ; oboInOwl:id "HP:0001557" ; a owl:Class ; rdfs:comment "Fetal movements generally become apparent during the second trimester of pregnancy around the 20th week but occasionally up to the 25th week. The initiation of perceptible fetal movements is referred to as 'quickening'." ; rdfs:label "Prenatal movement abnormality" ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0001558 obo:IAO_0000115 "An abnormal reduction in quantity or strength of fetal movements." ; oboInOwl:hasAlternativeId "HP:0001559", "HP:0006840", "HP:0007630", "HP:0007631" ; oboInOwl:hasDbXref "SNOMEDCT_US:276369006", "UMLS:C0235659" ; oboInOwl:hasExactSynonym "Decreased fetal activity", "Decreased fetal movements", "Decreased foetal activity", "Decreased foetal movement", "Decreased foetal movements", "Decreased movement in utero", "Dminished fetal movement", "Dminished foetal movement", "Fetal hypokinesia", "Foetal hypokinesia", "Less than 10 fetal movements in 12 hours", "Less than 10 foetal movements in 12 hours", "Reduced fetal movement", "Reduced fetal movements", "Reduced foetal movement", "Reduced foetal movements" ; oboInOwl:id "HP:0001558" ; a owl:Class ; rdfs:label "Decreased fetal movement" ; rdfs:subClassOf obo:HP_0001557 . obo:HP_0001560 obo:IAO_0000115 "Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus." ; oboInOwl:hasDbXref "SNOMEDCT_US:42170009", "UMLS:C0266781" ; oboInOwl:hasExactSynonym "Abnormal amniotic fluid" ; oboInOwl:id "HP:0001560" ; a owl:Class ; rdfs:label "Abnormality of the amniotic fluid" ; rdfs:subClassOf obo:HP_0001197 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001561 obo:IAO_0000115 "The presence of excess amniotic fluid in the uterus during pregnancy." ; oboInOwl:hasAlternativeId "HP:0005098" ; oboInOwl:hasDbXref "MSH:D006831", "SNOMEDCT_US:86203003", "UMLS:C0020224" ; oboInOwl:hasExactSynonym "High levels of amniotic fluid", "Hydramnios" ; oboInOwl:hasRelatedSynonym "Increased amniotic fluid index" ; oboInOwl:id "HP:0001561" ; a owl:Class ; rdfs:comment "Polyhydramnios is diagnosed if the deepest vertical pool of amniotic fluid is more than 8 cm or amniotic fluid index is more than 95th percentile for the corresponding gestational age." ; rdfs:label "Polyhydramnios" ; rdfs:subClassOf obo:HP_0001560 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000173 [ a owl:Restriction ; owl:onProperty obo:RO_0002490 ; owl:someValuesFrom obo:GO_0007565 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001562 obo:IAO_0000115 "Diminished amniotic fluid volume in pregnancy." ; oboInOwl:hasAlternativeId "HP:0004638" ; oboInOwl:hasDbXref "MSH:D016104", "SNOMEDCT_US:59566000", "UMLS:C0079924", "UMLS:C3550658" ; oboInOwl:hasExactSynonym "Low levels of amniotic fluid", "Maternal oligohydramnios" ; oboInOwl:hasRelatedSynonym "Decreased amniotic fluid index" ; oboInOwl:id "HP:0001562" ; a owl:Class ; rdfs:comment "Oligohydramnios is the opposite of polyhydramnios. In normal pregnancy the amniotic fluid volume increases by about 10 ml/day until the 34th, after which it slowly diminishes. A normal amniotic fluid volume at term is about 500-2,000 ml. Oligohydramnios is defined as an AFI (amniotic fluid index) less than 5 cm or smallest vertical pocket of fluid less than 2 cm." ; rdfs:label "Oligohydramnios" ; rdfs:subClassOf obo:HP_0001560 . obo:HP_0001563 obo:IAO_0000115 "Abnormally increased production of urine by the fetus resulting in polyhydramnios." ; oboInOwl:hasDbXref "UMLS:C1865279" ; oboInOwl:hasExactSynonym "Foetal polyuria" ; oboInOwl:id "HP:0001563" ; a owl:Class ; rdfs:comment "The fetal urine production rate can be measured by ultrasonography." ; rdfs:label "Fetal polyuria" ; rdfs:subClassOf obo:HP_0001560 . obo:HP_0001566 obo:IAO_0000115 "Increased distance between the maxillary central permanent incisor tooth." ; oboInOwl:hasAlternativeId "HP:0000669", "HP:0001570", "HP:0006300", "HP:0006324" ; oboInOwl:hasBroadSynonym "Central incisor gap" ; oboInOwl:hasDbXref "UMLS:C1835762", "UMLS:C1845110", "UMLS:C4280252" ; oboInOwl:hasExactSynonym "Diastasis of the central incisors", "Gap between upper front teeth", "Separated superior central incisors", "Wide gap between upper central incisors", "Wide upper central incisors", "Widely spaced upper incisors" ; oboInOwl:hasNarrowSynonym "Diastema between maxillary central incisors", "Diastema between upper front teeth", "Diastema between upper incisors" ; oboInOwl:id "HP:0001566" ; a owl:Class ; rdfs:label "Widely-spaced maxillary central incisors" ; rdfs:subClassOf obo:HP_0006304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001571 obo:IAO_0000115 "The presence of multiple impacted teeth." ; oboInOwl:hasBroadSynonym "Multiple buried teeth", "Multiple retained teeth" ; oboInOwl:hasDbXref "UMLS:C1839965", "UMLS:C4280593" ; oboInOwl:hasExactSynonym "Impacted teeth", "Multiple impacted teeth" ; oboInOwl:id "HP:0001571" ; a owl:Class ; rdfs:label "Multiple impacted teeth" ; rdfs:subClassOf obo:HP_0011079 . obo:HP_0001572 obo:IAO_0000115 "Increased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD above mean for age. Alternatively, an apparently increased maximum width of the tooth." ; oboInOwl:hasBroadSynonym "Hyperplasia of tooth", "Hypertrophy of tooth" ; oboInOwl:hasDbXref "SNOMEDCT_US:71485000", "UMLS:C0266036", "UMLS:C4280590", "UMLS:C4280591", "UMLS:C4280592" ; oboInOwl:hasExactSynonym "Increased size of tooth", "Increased width of tooth", "Large tooth", "Megalodontia" ; oboInOwl:hasRelatedSynonym "Tooth mass excess" ; oboInOwl:id "HP:0001572" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The standard reference has means and standard deviations by gender [Moyers et al, 1976]. Although it is easy to measure the width of teeth, and the definition is made with reference to the width of teeth, macrodontia actually means that the overall size of the tooth is increased." ; rdfs:label "Macrodontia" ; rdfs:subClassOf obo:HP_0006482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001574 obo:IAO_0000115 "An abnormality of the integument, which consists of the skin and the superficial fascia." ; oboInOwl:hasDbXref "UMLS:C4025761" ; oboInOwl:id "HP:0001574" ; a owl:Class ; rdfs:comment "Abnormality of skin, hair, or nails." ; rdfs:label "Abnormality of the integument" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001575 obo:IAO_0100001 "HP:0000712" ; oboInOwl:id "HP:0001575" ; a owl:Class ; rdfs:label "obsolete Mood changes" ; owl:deprecated true . obo:HP_0001579 obo:IAO_0000115 "Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol." ; oboInOwl:hasDbXref "UMLS:C1968852", "UMLS:C4025760" ; oboInOwl:hasRelatedSynonym "ACTH-independent hypercortisolemia" ; oboInOwl:id "HP:0001579" ; a owl:Class ; rdfs:label "Primary hypercortisolism" ; rdfs:subClassOf obo:HP_0003118 . obo:HP_0001580 oboInOwl:hasDbXref "UMLS:C1968851" ; oboInOwl:id "HP:0001580" ; a owl:Class ; rdfs:label "Pigmented micronodular adrenocortical disease" ; rdfs:subClassOf obo:HP_0000849 . obo:HP_0001581 obo:IAO_0000115 "Infections of the skin that happen multiple times." ; oboInOwl:hasAlternativeId "HP:0007563" ; oboInOwl:hasDbXref "UMLS:C1853193" ; oboInOwl:hasExactSynonym "Cutaneous infections", "Recurrent skin infections", "Skin infections, recurrent" ; oboInOwl:id "HP:0001581" ; a owl:Class ; rdfs:label "Recurrent skin infections" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0001582 obo:IAO_0000115 "Loose and sagging skin often associated with loss of skin elasticity." ; oboInOwl:hasAlternativeId "HP:0007391" ; oboInOwl:hasDbXref "SNOMEDCT_US:201093004", "UMLS:C0581342" ; oboInOwl:hasExactSynonym "Loose redundant skin", "Redundant skin folds", "Sagging, redundant skin" ; oboInOwl:id "HP:0001582" ; a owl:Class ; rdfs:label "Redundant skin" ; rdfs:subClassOf obo:HP_0000973 . obo:HP_0001583 obo:IAO_0000115 "A form of nystagmus in which the eyeball makes rotary motions around the axis." ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:44526006", "SNOMEDCT_US:95783006", "UMLS:C0240595" ; oboInOwl:hasExactSynonym "Rotatory Nystagmus" ; oboInOwl:id "HP:0001583" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Rotary nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0001586 obo:IAO_0000115 "The presence of a fistula connecting the urinary bladder to the vagina." ; oboInOwl:hasDbXref "MSH:D014719", "SNOMEDCT_US:89405008", "UMLS:C0042582" ; oboInOwl:id "HP:0001586" ; a owl:Class ; rdfs:label "Vesicovaginal fistula" ; rdfs:subClassOf obo:HP_0004320, obo:HP_0004321 . obo:HP_0001587 oboInOwl:id "HP:0001587" ; a owl:Class ; rdfs:label "obsolete Primary ovarian failure" ; owl:deprecated true . obo:HP_0001591 obo:IAO_0000115 "The rib cage has the shape of a wide mouthed bell. That is, the superior portion of the rib cage is constricted, followed by a convex region, and the inferior portion of the rib cage expands again to have a large diameter." ; oboInOwl:hasAlternativeId "HP:0006626", "HP:0006664" ; oboInOwl:hasDbXref "UMLS:C1865186" ; oboInOwl:hasExactSynonym "Bell-shaped chest", "Constricted, bell-shaped thorax", "Narrow, bell-shaped thorax" ; oboInOwl:id "HP:0001591" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A bell-shaped thorax is a non-specific finding. In newborns, bell-spahed thorax can indicate a history of intrauterine neuromuscular abnormalities." ; rdfs:label "Bell-shaped thorax" ; rdfs:subClassOf obo:HP_0001547 . obo:HP_0001592 obo:IAO_0000115 "Agenesis specifically affecting one of the classes incisor, premolar, or molar." ; oboInOwl:hasDbXref "UMLS:C1970308", "UMLS:C4280251" ; oboInOwl:hasExactSynonym "Agenesis of a tooth", "Failure of development of a tooth" ; oboInOwl:hasRelatedSynonym "Absence of a tooth", "Missing a tooth" ; oboInOwl:id "HP:0001592" ; a owl:Class ; rdfs:label "Selective tooth agenesis" ; rdfs:subClassOf obo:HP_0009804 . obo:HP_0001593 obo:IAO_0000115 "Decreased size of the maxillary permanent incisor." ; oboInOwl:hasBroadSynonym "Decreased size of maxillary lateral incisor", "Decreased size of upper lateral incisor", "Hypotrophic maxillary lateral incisor", "Hypotrophic upper lateral incisor", "Small maxillary lateral incisor", "Small upper lateral incisor" ; oboInOwl:hasDbXref "UMLS:C1845111", "UMLS:C4280588", "UMLS:C4280589" ; oboInOwl:hasExactSynonym "Decreased width of upper lateral incisor" ; oboInOwl:id "HP:0001593" ; a owl:Class ; rdfs:label "Maxillary lateral incisor microdontia" ; rdfs:subClassOf obo:HP_0000691, obo:HP_0011063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001595 obo:IAO_0000115 "An abnormality of the hair." ; oboInOwl:hasDbXref "UMLS:C0157733", "UMLS:C2677869" ; oboInOwl:hasExactSynonym "Abnormality of the hair", "Hair abnormality" ; oboInOwl:hasNarrowSynonym "Abnormality of the hair shaft" ; oboInOwl:id "HP:0001595" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal hair morphology" ; rdfs:subClassOf obo:HP_0011138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001596 obo:IAO_0000115 "A noncongenital process of hair loss, which may progress to partial or complete baldness." ; oboInOwl:hasAlternativeId "HP:0002238", "HP:0008068" ; oboInOwl:hasDbXref "MEDDRA:10001760", "MSH:D000505", "SNOMEDCT_US:278040002", "SNOMEDCT_US:56317004", "UMLS:C0002170" ; oboInOwl:hasExactSynonym "Hair loss" ; oboInOwl:id "HP:0001596" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Alopecia" ; rdfs:subClassOf obo:HP_0011362 . obo:HP_0001597 obo:IAO_0000115 "Abnormality of the nail." ; oboInOwl:hasDbXref "MSH:D009260", "MSH:D009264", "SNOMEDCT_US:17790008", "UMLS:C0027339", "UMLS:C0853087" ; oboInOwl:hasExactSynonym "Abnormality of the nail" ; oboInOwl:hasRelatedSynonym "Nail disease" ; oboInOwl:id "HP:0001597" ; a owl:Class ; rdfs:comment "Abnormality of the fingernails and/or toenails." ; rdfs:label "Abnormality of the nail" ; rdfs:subClassOf obo:HP_0011138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001598 obo:IAO_0000115 "The natural longitudinal (posterodistal) convex arch is not present or is inverted." ; oboInOwl:hasAlternativeId "HP:0001815" ; oboInOwl:hasDbXref "SNOMEDCT_US:66270006", "UMLS:C0221261" ; oboInOwl:hasExactSynonym "Koilonychia", "Spoon-shaped nails" ; oboInOwl:id "HP:0001598" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Koilonychia literally means spoon nails. This often results in a saucer- or spoon-shaped nail and the free edge of the nail is typically everted. The affected digits should be specified. Note that the bundled term koilonychia is an abnormal shape of the fingernail where the nail has raised ridges and is thin and concave." ; rdfs:label "Concave nail" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0001600 obo:IAO_0000115 "An abnormality of the larynx." ; oboInOwl:hasDbXref "UMLS:C4021777" ; oboInOwl:hasExactSynonym "Laryngeal abnormalities", "Laryngeal anomalies" ; oboInOwl:id "HP:0001600" ; a owl:Class ; rdfs:label "Abnormality of the larynx" ; rdfs:subClassOf obo:HP_0002087 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001601 obo:IAO_0000115 "Laryngomalacia is a congenital abnormality of the laryngeal cartilage in which the cartilage is floppy and prolapses over the larynx during inspiration." ; oboInOwl:hasDbXref "MSH:D055092", "SNOMEDCT_US:38086007", "UMLS:C0264303" ; oboInOwl:hasExactSynonym "Softening of voice box tissue" ; oboInOwl:id "HP:0001601" ; a owl:Class ; rdfs:comment "Laryngomalacia may affect the epiglottis, the arytenoid cartilages, or both. It is the most common cause of congenital stridor." ; rdfs:label "Laryngomalacia" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0001602 obo:IAO_0000115 "Stricture or narrowing of the larynx that may be associated with symptoms of respiratory difficulty depending on the degree of laryngeal narrowing." ; oboInOwl:hasDbXref "MSH:D007829", "SNOMEDCT_US:75547007", "UMLS:C0023075" ; oboInOwl:id "HP:0001602" ; a owl:Class ; rdfs:label "Laryngeal stenosis" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001604 obo:IAO_0000115 "Decreased strength of the vocal folds." ; oboInOwl:hasAlternativeId "HP:0001603", "HP:0001616", "HP:0008745" ; oboInOwl:hasDbXref "MSH:D014826", "SNOMEDCT_US:302912005", "SNOMEDCT_US:445424004", "UMLS:C0751576", "UMLS:C1832690", "UMLS:C1843187", "UMLS:C1853729" ; oboInOwl:hasExactSynonym "Hoarse voice due to vocal cord paresis", "Vocal cord paresis in severe cases", "Weakness of the vocal cords" ; oboInOwl:id "HP:0001604" ; a owl:Class ; rdfs:comment "Vocal cord paresis can be characterized by a hoarseness, reduced volume of speech, aspiration and pain in the throat." ; rdfs:label "Vocal cord paresis" ; rdfs:subClassOf obo:HP_0001605 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001605 obo:IAO_0000115 "A loss of the ability to move the vocal folds." ; oboInOwl:hasAlternativeId "HP:0001606", "HP:0006847" ; oboInOwl:hasDbXref "MSH:D014826", "SNOMEDCT_US:302912005", "UMLS:C0042928", "UMLS:C1854345" ; oboInOwl:hasExactSynonym "Inability to move vocal cords", "Laryngeal paralysis" ; oboInOwl:id "HP:0001605" ; a owl:Class ; rdfs:comment "Vocal cord paralysis may lead to signs and symptoms such as hoarseness, inability to speak loudly, choking or coughing while eating with the risk of aspiration pneumonia. Affected patients may also experience breathing difficulties." ; rdfs:label "Vocal cord paralysis" ; rdfs:subClassOf obo:HP_0003470, obo:HP_0031801 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001606 obo:IAO_0100001 "HP:0001605" ; oboInOwl:id "HP:0001606" ; a owl:Class ; rdfs:label "obsolete Vocal cord paralysis (caused by tumor impingement)" ; owl:deprecated true . obo:HP_0001607 oboInOwl:hasDbXref "SNOMEDCT_US:22668006", "UMLS:C0238441" ; oboInOwl:id "HP:0001607" ; a owl:Class ; rdfs:label "Subglottic stenosis" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0001608 oboInOwl:hasDbXref "UMLS:C4021776" ; oboInOwl:hasExactSynonym "Abnormality of the voice", "Voice abnormality" ; oboInOwl:id "HP:0001608" ; a owl:Class ; rdfs:comment "This term describes any abnormality of the voice, i.e., of the sounds produced by humans by the passage of air through the larynx and over the vocal cords, and then modified by the resonance organs, the nasopharynx, and the mouth." ; rdfs:label "Abnormality of the voice" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0034681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001609 obo:IAO_0000115 "Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky." ; oboInOwl:hasAlternativeId "HP:0001613", "HP:0001619" ; oboInOwl:hasDbXref "MSH:D006685", "SNOMEDCT_US:50219008", "UMLS:C0019825", "UMLS:C1854348" ; oboInOwl:hasExactSynonym "Hoarse voice", "Hoarseness", "Husky voice" ; oboInOwl:id "HP:0001609" ; a owl:Class ; rdfs:label "Hoarse voice" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0001611 obo:IAO_0000115 "A type of speech characterized by the presence of an abnormally increased nasal airflow during speech associated with structural abnormality of the nasal passages." ; dcterms:contributor , , , ; oboInOwl:hasAlternativeId "HP:0001614" ; oboInOwl:hasDbXref "SNOMEDCT_US:229645001", "SNOMEDCT_US:289190003", "UMLS:C0454555", "UMLS:C0566620" ; oboInOwl:hasExactSynonym "Hypernasal voice", "Nasal speech", "Nasal voice" ; oboInOwl:id "HP:0001611" ; a owl:Class ; rdfs:comment "May be associated with incomplete or weak closure of the velum. Examination is by nasal endoscopy." ; rdfs:label "Hypernasal speech" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0001612 oboInOwl:hasDbXref "SNOMEDCT_US:2120003", "UMLS:C0234860" ; oboInOwl:id "HP:0001612" ; a owl:Class ; rdfs:label "Weak cry" ; rdfs:subClassOf obo:HP_0025429 . obo:HP_0001613 obo:IAO_0100001 "HP:0001609" ; oboInOwl:id "HP:0001613" ; a owl:Class ; rdfs:label "obsolete Hoarse voice (caused by tumor impingement)" ; owl:deprecated true . obo:HP_0001615 oboInOwl:hasDbXref "UMLS:C2678303" ; oboInOwl:hasExactSynonym "Hoarse cry" ; oboInOwl:id "HP:0001615" ; a owl:Class ; rdfs:label "Hoarse cry" ; rdfs:subClassOf obo:HP_0001609 . obo:HP_0001618 obo:IAO_0000115 "Difficulty in speaking due to a physical disorder of the mouth, tongue, throat, or vocal cords. Associated with a known physical or neurological cause." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "MSH:D055154", "SNOMEDCT_US:47004009", "UMLS:C1527344" ; oboInOwl:hasExactSynonym "Inability to produce voice sounds", "Voice change" ; oboInOwl:id "HP:0001618" ; a owl:Class ; rdfs:label "Dysphonia" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0001620 obo:IAO_0000115 "An abnormal increase in the pitch (frequency) of the voice." ; dcterms:contributor , , , ; oboInOwl:hasAlternativeId "HP:0001610", "HP:0008374", "HP:0008377", "HP:0008378", "HP:0008379", "HP:0009146" ; oboInOwl:hasDbXref "SNOMEDCT_US:51406002", "UMLS:C0241703" ; oboInOwl:hasExactSynonym "Abnormally high-pitched voice", "High pitched voice", "High-pitched voice" ; oboInOwl:id "HP:0001620" ; a owl:Class ; rdfs:label "High pitched voice" ; rdfs:subClassOf obo:HP_5200005 . obo:HP_0001621 obo:IAO_0000115 "Reduced intensity (volume) of speech." ; oboInOwl:hasDbXref "MSH:D014832", "SNOMEDCT_US:34527004", "SNOMEDCT_US:8614008", "UMLS:C0241700", "UMLS:C0521007" ; oboInOwl:hasExactSynonym "Quiet voice", "Soft voice", "Weak voice" ; oboInOwl:hasRelatedSynonym "Hypophonia" ; oboInOwl:id "HP:0001621" ; a owl:Class ; rdfs:comment "Hypophonia refers to an abnormally weak voice due to incoordination of the muscles concerned in vocalization." ; rdfs:label "Weak voice" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0001622 obo:IAO_0000115 "The birth of a baby of less than 37 weeks of gestational age." ; oboInOwl:hasDbXref "MSH:D047928", "SNOMEDCT_US:282020008", "SNOMEDCT_US:367494004", "SNOMEDCT_US:49550006", "UMLS:C0151526", "UMLS:C0233315" ; oboInOwl:hasExactSynonym "Premature birth", "Premature delivery", "Premature delivery of affected infants", "Preterm birth", "Preterm delivery", "Shortened gestation time" ; oboInOwl:id "HP:0001622" ; a owl:Class ; rdfs:label "Premature birth" ; rdfs:subClassOf obo:HP_0001197 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001623 obo:IAO_0000115 "A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first." ; oboInOwl:hasDbXref "MSH:D001946", "SNOMEDCT_US:249101006", "SNOMEDCT_US:6096002", "UMLS:C0006157" ; oboInOwl:hasExactSynonym "Breech presentation at birth", "Feet or buttocks of fetus positioned near opening of uterus", "Feet or buttocks of foetus positioned near opening of uterus" ; oboInOwl:id "HP:0001623" ; a owl:Class ; rdfs:label "Breech presentation" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0001626 obo:IAO_0000115 "Any abnormality of the cardiovascular system." ; oboInOwl:hasAlternativeId "HP:0003116" ; oboInOwl:hasDbXref "MSH:D002318", "MSH:D018376", "SNOMEDCT_US:49601007", "UMLS:C0007222", "UMLS:C0243050" ; oboInOwl:hasExactSynonym "Abnormality of the cardiovascular system", "Cardiovascular abnormality" ; oboInOwl:hasRelatedSynonym "Cardiovascular disease" ; oboInOwl:id "HP:0001626" ; a owl:Class ; rdfs:comment "The cardiovascular system consists of the heart, vasculature, and the lymphatic system." ; rdfs:label "Abnormality of the cardiovascular system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001627 obo:IAO_0000115 "Any structural anomaly of the heart." ; oboInOwl:hasAlternativeId "HP:3000001" ; oboInOwl:hasDbXref "MSH:D006330", "SNOMEDCT_US:13213009", "UMLS:C0018798", "UMLS:C0152021" ; oboInOwl:hasExactSynonym "Abnormality of cardiac morphology", "Abnormality of the heart", "Abnormally shaped heart", "Cardiac abnormality", "Cardiac anomalies", "Cardiac anomaly", "Congenital heart defect", "Congenital heart defects", "Heart defect" ; oboInOwl:id "HP:0001627" ; a owl:Class ; rdfs:label "Abnormal heart morphology" ; rdfs:subClassOf obo:HP_0030680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001629 obo:IAO_0000115 "A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum." ; oboInOwl:hasAlternativeId "HP:0001652" ; oboInOwl:hasDbXref "Fyler:1300", "MSH:D006345", "SNOMEDCT_US:253549006", "SNOMEDCT_US:30288003", "UMLS:C0018818" ; oboInOwl:hasExactSynonym "Hole in heart wall separating two lower heart chambers", "VSD", "Ventricular septal defects", "Ventriculoseptal defect" ; oboInOwl:id "HP:0001629" ; a owl:Class ; rdfs:label "Ventricular septal defect" ; rdfs:subClassOf obo:HP_0010438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001631 obo:IAO_0000115 "Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum." ; oboInOwl:hasAlternativeId "HP:0001630" ; oboInOwl:hasDbXref "Fyler:2050", "ICD-10:Q21.1", "MSH:D006344", "SNOMEDCT_US:253366007", "SNOMEDCT_US:405752007", "SNOMEDCT_US:70142008", "UMLS:C0018817" ; oboInOwl:hasExactSynonym "ASD", "An opening in the wall separating the top two chambers of the heart", "Atria septal defect", "Atrial septum defect", "Atrioseptal defect", "Defect in the atrial septum", "Hole in heart wall separating two upper heart chambers" ; oboInOwl:id "HP:0001631" ; a owl:Class ; rdfs:label "Atrial septal defect" ; rdfs:subClassOf obo:HP_0005120, obo:HP_0011994 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001633 obo:IAO_0000115 "Any structural anomaly of the mitral valve." ; oboInOwl:hasAlternativeId "HP:0031477" ; oboInOwl:hasDbXref "UMLS:C4025759" ; oboInOwl:hasExactSynonym "Abnormality of the mitral valve" ; oboInOwl:id "HP:0001633" ; a owl:Class ; rdfs:label "Abnormal mitral valve morphology" ; rdfs:subClassOf obo:HP_0006705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001634 obo:IAO_0000115 "One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle." ; oboInOwl:hasDbXref "Fyler:1533", "MSH:D008945", "SNOMEDCT_US:409712001", "SNOMEDCT_US:8074002", "UMLS:C0026267" ; oboInOwl:id "HP:0001634" ; a owl:Class ; rdfs:comment "Mitral valve prolapse can be associated with mitral regurgitation." ; rdfs:label "Mitral valve prolapse" ; rdfs:subClassOf obo:HP_0001633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001635 obo:IAO_0000115 "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." ; oboInOwl:hasAlternativeId "HP:0006686" ; oboInOwl:hasDbXref "MSH:D006333", "SNOMEDCT_US:42343007", "SNOMEDCT_US:84114007", "UMLS:C0018801", "UMLS:C0018802" ; oboInOwl:hasExactSynonym "CHF", "Cardiac failure", "Cardiac failures", "Cardiac insufficiency", "Chronic heart failure", "Heart failure" ; oboInOwl:id "HP:0001635" ; a owl:Class ; rdfs:label "Congestive heart failure" ; rdfs:subClassOf obo:HP_0011025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060047 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001636 obo:IAO_0000115 "A congenital cardiac malformation comprising pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy. The diagnosis of TOF is made if at least three of the four above mentioned features are present." ; oboInOwl:hasDbXref "ICD-10:Q21.3", "MSH:D013771", "SNOMEDCT_US:86299006", "UMLS:C0039685" ; oboInOwl:hasExactSynonym "Tetrology of fallot" ; oboInOwl:id "HP:0001636" ; a owl:Class ; rdfs:label "Tetralogy of Fallot" ; rdfs:subClassOf obo:HP_0001710 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001629 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001642 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001667 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0002623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001637 obo:IAO_0000115 "A structural anomaly of the muscle layer of the heart wall." ; oboInOwl:hasDbXref "UMLS:C4025758" ; oboInOwl:hasExactSynonym "Abnormality of the myocardium" ; oboInOwl:id "HP:0001637" ; a owl:Class ; rdfs:label "Abnormal myocardium morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001638 obo:IAO_0000115 "A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality." ; oboInOwl:hasDbXref "Fyler:1840", "MSH:D009202", "SNOMEDCT_US:57809008", "SNOMEDCT_US:85898001", "UMLS:C0878544" ; oboInOwl:hasExactSynonym "Disease of the heart muscle" ; oboInOwl:id "HP:0001638" ; a owl:Class ; rdfs:label "Cardiomyopathy" ; rdfs:subClassOf obo:HP_0001637 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001639 obo:IAO_0000115 "Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality." ; oboInOwl:hasDbXref "MSH:D002312", "SNOMEDCT_US:233873004", "SNOMEDCT_US:45227007", "UMLS:C0007194" ; oboInOwl:hasExactSynonym "Cardiomyopathy, hypertrophic", "Enlarged and thickened heart muscle", "HCM" ; oboInOwl:id "HP:0001639" ; a owl:Class ; rdfs:label "Hypertrophic cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0001640 obo:IAO_0000115 "Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography." ; oboInOwl:hasDbXref "MSH:D006332", "SNOMEDCT_US:8186001", "UMLS:C0018800" ; oboInOwl:hasExactSynonym "Enlarged heart", "Increased heart size" ; oboInOwl:id "HP:0001640" ; a owl:Class ; rdfs:label "Cardiomegaly" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001641 obo:IAO_0000115 "Any structural abnormality of the pulmonary valve." ; oboInOwl:hasDbXref "Fyler:1600", "Fyler:1602", "SNOMEDCT_US:448643005", "UMLS:C3164374" ; oboInOwl:hasExactSynonym "Abnormality of the pulmonary valve", "Anomaly of the pulmonary valve" ; oboInOwl:id "HP:0001641" ; a owl:Class ; rdfs:label "Abnormal pulmonary valve morphology" ; rdfs:subClassOf obo:HP_0001654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001642 obo:IAO_0000115 "A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis)." ; oboInOwl:hasDbXref "Fyler:1611", "MSH:D011666", "SNOMEDCT_US:56786000", "UMLS:C1956257" ; oboInOwl:hasExactSynonym "Narrowing of pulmonic valve", "Pulmonary stenosis", "Pulmonary valve stenosis", "Pulmonic valve stenosis" ; oboInOwl:id "HP:0001642" ; a owl:Class ; rdfs:comment "Pulmonic stenosis is often seen as a part of Fallot' s tetralogy, in which case the events leading to the formation of the overriding aorta are also believed to be a cause of the pulmonic stenosis. The pulmonic stenosis is the major cause of the malformations seen in patients with Fallot tetralogy, with the other associated malformations acting as compensatory mechanisms to the pulmonic stenosis. The degree of stenosis varies between individuals with TOF, and is the primary determinant of symptoms and severity." ; rdfs:label "Pulmonic stenosis" ; rdfs:subClassOf obo:HP_0031654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001643 obo:IAO_0000115 "In utero, the ductus arteriosus (DA) serves to divert ventricular output away from the lungs and toward the placenta by connecting the main pulmonary artery to the descending aorta. A patent ductus arteriosus (PDA) in the first 3 days of life is a physiologic shunt in healthy term and preterm newborn infants, and normally is substantially closed within about 24 hours after bith and completely closed after about three weeks. Failure of physiologcal closure is referred to a persistent or patent ductus arteriosus (PDA). Depending on the degree of left-to-right shunting, PDA can have clinical consequences." ; oboInOwl:hasDbXref "Fyler:2100", "MSH:D004374", "SNOMEDCT_US:83330001", "UMLS:C0013274" ; oboInOwl:hasExactSynonym "Ductus arteriosus", "PDA", "Patent ductus Botalli", "Persistent arterial duct", "Persistent ductus arteriosus" ; oboInOwl:id "HP:0001643" ; a owl:Class ; rdfs:label "Patent ductus arteriosus" ; rdfs:subClassOf obo:HP_0011603 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005440 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001644 obo:IAO_0000115 "Dilated cardiomyopathy (DCM) is defined by the presence of left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary artery disease sufficient to cause global systolic impairment. Right ventricular dilation and dysfunction may be present but are not necessary for the diagnosis." ; oboInOwl:hasAlternativeId "HP:0001725", "HP:0005159", "HP:0200130" ; oboInOwl:hasDbXref "Fyler:1843", "MSH:D002311", "SNOMEDCT_US:195021004", "SNOMEDCT_US:399020009", "UMLS:C0007193" ; oboInOwl:hasExactSynonym "Cardiomyopathy, dilated", "Congestive cardiomyopathy", "DCM", "Stretched and thinned heart muscle" ; oboInOwl:id "HP:0001644" ; a owl:Class ; rdfs:label "Dilated cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0001645 obo:IAO_0000115 "The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset)." ; oboInOwl:hasAlternativeId "HP:0005161" ; oboInOwl:hasDbXref "MSH:D016757", "SNOMEDCT_US:95281009", "UMLS:C0085298" ; oboInOwl:hasExactSynonym "Premature sudden cardiac death", "Sudden cardiac death" ; oboInOwl:id "HP:0001645" ; a owl:Class ; rdfs:label "Sudden cardiac death" ; rdfs:subClassOf obo:HP_0001695, obo:HP_0001699 . obo:HP_0001646 obo:IAO_0000115 "Any abnormality of the aortic valve." ; oboInOwl:hasDbXref "Fyler:1400", "Fyler:1408", "SNOMEDCT_US:448743001", "UMLS:C3164445" ; oboInOwl:hasExactSynonym "Abnormality of the aortic valve" ; oboInOwl:id "HP:0001646" ; a owl:Class ; rdfs:label "Abnormal aortic valve morphology" ; rdfs:subClassOf obo:HP_0001654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001647 obo:IAO_0000115 "The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps)." ; oboInOwl:hasDbXref "MSH:C562388", "SNOMEDCT_US:72352009", "UMLS:C0149630" ; oboInOwl:hasExactSynonym "Aortic valve has two leaflets rather than three" ; oboInOwl:id "HP:0001647" ; a owl:Class ; rdfs:comment "A normal aortic valve is composed of three aortic-valve cusps, each semilunar in appearance. The leaflets are housed within a small dilatation of the proximal aorta associated with each cusp, called the sinuses of Valsalva or aortic sinuses, and their association with the respective coronary ostia identifies them: left, right, and non-coronary sinuses. Each cusp is attached to the wall of the aorta by the outward edges of its semicircular border, and the attachment point between each leaflet is called a commissure [PMID:24827036]." ; rdfs:label "Bicuspid aortic valve" ; rdfs:subClassOf obo:HP_0031567 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002281 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001648 obo:IAO_0000115 "Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle." ; oboInOwl:hasDbXref "MSH:D011660", "SNOMEDCT_US:274096000", "SNOMEDCT_US:83291003", "UMLS:C0034072" ; oboInOwl:id "HP:0001648" ; a owl:Class ; rdfs:comment "Cor pulmonale refers to a change in structure and function of the right ventricle of the heart as a result of a pulmonary disorder, generally resulting in right ventricular hypertrophy." ; rdfs:label "Cor pulmonale" ; rdfs:subClassOf obo:HP_0001707 . obo:HP_0001649 obo:IAO_0000115 "A rapid heartrate that exceeds the range of the normal resting heartrate for age." ; oboInOwl:hasAlternativeId "HP:0001673", "HP:0001720" ; oboInOwl:hasDbXref "MSH:D013610", "SNOMEDCT_US:3424008", "SNOMEDCT_US:86651002", "UMLS:C0039231", "UMLS:C4020868" ; oboInOwl:hasExactSynonym "Fast heart rate", "Heart racing", "Racing heart" ; oboInOwl:hasRelatedSynonym "Elevated heart rate", "Increased heart rate", "Rapid heart beat" ; oboInOwl:id "HP:0001649" ; a owl:Class ; rdfs:label "Tachycardia" ; rdfs:subClassOf obo:HP_0004308, obo:HP_0011675 . obo:HP_0001650 obo:IAO_0000115 "The presence of a stenosis (narrowing) of the aortic valve." ; oboInOwl:hasAlternativeId "HP:0005140" ; oboInOwl:hasDbXref "Fyler:1411", "MSH:D001024", "SNOMEDCT_US:60573004", "UMLS:C0003507" ; oboInOwl:hasExactSynonym "Aortic stenosis", "Narrowing of aortic valve", "Valvular aortic stenosis" ; oboInOwl:id "HP:0001650" ; a owl:Class ; rdfs:comment "Aortic stenosis can lead to a pressure gradient between the left ventricle and the aorta and may result in left ventricular hypertrophy and decreased left ventricular compliance." ; rdfs:label "Aortic valve stenosis" ; rdfs:subClassOf obo:HP_0031652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001651 obo:IAO_0000115 "The heart is located in the right hand sided hemithorax. That is, there is a left-right reversal (or \"mirror reflection\") of the anatomical location of the heart in which the heart is locate on the right side instead of the left." ; oboInOwl:hasDbXref "EPCC:02.01.02", "Fyler:0110", "Fyler:110", "ICD-10:Q24.0", "MSH:D003914", "SNOMEDCT_US:27637000", "UMLS:C0011813" ; oboInOwl:hasExactSynonym "Heart tip and four chambers point towards right side of body", "Thoracic situs inversus" ; oboInOwl:id "HP:0001651" ; a owl:Class ; rdfs:label "Dextrocardia" ; rdfs:subClassOf obo:HP_0004307 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001793 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001653 obo:IAO_0000115 "An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction." ; oboInOwl:hasDbXref "Fyler:1151", "MSH:D008944", "SNOMEDCT_US:48724000", "UMLS:C0026266", "UMLS:C3551535" ; oboInOwl:hasExactSynonym "Mitral incompetence", "Mitral insufficiency", "Mitral valve insufficiency", "Mitral valve regurgitation" ; oboInOwl:hasRelatedSynonym "Mitral regurgitation, mild" ; oboInOwl:id "HP:0001653" ; a owl:Class ; rdfs:label "Mitral regurgitation" ; rdfs:subClassOf obo:HP_0031481, obo:HP_0034376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001654 obo:IAO_0000115 "Any structural abnormality of a cardiac valve." ; oboInOwl:hasAlternativeId "HP:0001703" ; oboInOwl:hasDbXref "MSH:D006349", "SNOMEDCT_US:368009", "UMLS:C0018824", "UMLS:C0241654" ; oboInOwl:hasExactSynonym "Abnormality of the heart valves", "Valvular abnormality" ; oboInOwl:hasRelatedSynonym "Valvular heart disease" ; oboInOwl:id "HP:0001654" ; a owl:Class ; rdfs:label "Abnormal heart valve morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000946 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001655 obo:IAO_0000115 "Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria." ; oboInOwl:hasDbXref "Fyler:2020", "ICD-10:Q21.1", "MSH:D054092", "SNOMEDCT_US:204317008", "UMLS:C0016522" ; oboInOwl:hasExactSynonym "Persistent foramen ovale" ; oboInOwl:id "HP:0001655" ; a owl:Class ; rdfs:comment "The foramen ovale is located in the atrial septum and is essential for proper fetal circulation. With separation from the placenta and with the first few breaths, the left atrium fills with blood returning from the lungs and closes the foramen ovale. Subsequently, during the first years of life, the foramen ovale seals shut." ; rdfs:label "Patent foramen ovale" ; rdfs:subClassOf obo:HP_0001631 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001657 obo:IAO_0000115 "Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG)." ; oboInOwl:hasDbXref "SNOMEDCT_US:111975006", "UMLS:C0151878" ; oboInOwl:hasExactSynonym "Long QT syndrome", "Prolong qt interval on ekg" ; oboInOwl:hasRelatedSynonym "Long Q-T syndrome" ; oboInOwl:id "HP:0001657" ; a owl:Class ; rdfs:comment "The QT interval represents electrical depolarization and repolarization of the left and right ventricles." ; rdfs:label "Prolonged QT interval" ; rdfs:subClassOf obo:HP_0031547 . obo:HP_0001658 obo:IAO_0000115 "Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin." ; oboInOwl:hasDbXref "MSH:D009203", "SNOMEDCT_US:22298006", "UMLS:C0027051" ; oboInOwl:hasExactSynonym "Heart attack", "MI" ; oboInOwl:id "HP:0001658" ; a owl:Class ; rdfs:label "Myocardial infarction" ; rdfs:subClassOf obo:HP_0033678 . obo:HP_0001659 obo:IAO_0000115 "An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle." ; oboInOwl:hasDbXref "MSH:D001022", "SNOMEDCT_US:60234000", "UMLS:C0003504" ; oboInOwl:hasExactSynonym "Aortic insufficiency", "Aortic valve regurgitation" ; oboInOwl:id "HP:0001659" ; a owl:Class ; rdfs:label "Aortic regurgitation" ; rdfs:subClassOf obo:HP_0031652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001660 obo:IAO_0000115 "A single arterial trunk arises from the cardiac mass. The pulmonary arteries, aorta and coronary arteries arise from this single trunk with no evidence of another outflow tract." ; oboInOwl:hasDbXref "Fyler:0500", "Fyler:500", "ICD-10:Q20.0", "MSH:D014338", "SNOMEDCT_US:58140002", "UMLS:C0041206", "UMLS:C4020867" ; oboInOwl:hasExactSynonym "Common arterial trunk" ; oboInOwl:hasRelatedSynonym "Persistant truncus arteriosus" ; oboInOwl:id "HP:0001660" ; a owl:Class ; rdfs:label "Truncus arteriosus" ; rdfs:subClassOf obo:HP_0011603 . obo:HP_0001662 obo:IAO_0000115 "A slower than normal heart rate (in adults, slower than 60 beats per minute)." ; oboInOwl:hasDbXref "MSH:D001919", "SNOMEDCT_US:48867003", "UMLS:C0428977" ; oboInOwl:hasExactSynonym "Brachycardia", "Slow heartbeats" ; oboInOwl:id "HP:0001662" ; a owl:Class ; rdfs:label "Bradycardia" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0001663 obo:IAO_0000115 "Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations." ; oboInOwl:hasAlternativeId "HP:0005166" ; oboInOwl:hasDbXref "MSH:D014693", "SNOMEDCT_US:71908006", "UMLS:C0042510" ; oboInOwl:id "HP:0001663" ; a owl:Class ; rdfs:label "Ventricular fibrillation" ; rdfs:subClassOf obo:HP_0004308 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000688 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001664 obo:IAO_0000115 "A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG." ; oboInOwl:hasDbXref "MSH:D016171", "SNOMEDCT_US:31722008", "UMLS:C0040479" ; oboInOwl:hasExactSynonym "Torsades de pointes" ; oboInOwl:id "HP:0001664" ; a owl:Class ; rdfs:label "Torsade de pointes" ; rdfs:subClassOf obo:HP_0004308 . obo:HP_0001667 obo:IAO_0000115 "In this case the right ventricle is more muscular than normal, causing a characteristic boot-shaped (coeur-en-sabot) appearance as seen on anterior- posterior chest x-rays. Right ventricular hypertrophy is commonly associated with any form of right ventricular outflow obstruction or pulmonary hypertension, which may in turn owe its origin to left-sided disease. The echocardiographic signs are thickening of the anterior right ventricular wall and the septum. Cavity size is usually normal, or slightly enlarged. In many cases there is associated volume overload present due to tricuspid regurgitation, in the absence of this, septal motion is normal." ; oboInOwl:hasDbXref "Fyler:3609", "MSH:D017380", "SNOMEDCT_US:89792004", "UMLS:C0162770" ; oboInOwl:hasExactSynonym "Heart right ventricle hypertrophy" ; oboInOwl:id "HP:0001667" ; a owl:Class ; rdfs:label "Right ventricular hypertrophy" ; rdfs:subClassOf obo:HP_0001707, obo:HP_0001714 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002080 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001669 obo:IAO_0000115 "A complex congenital heart defect in which the aorta arises from the morphologic right ventricle and the pulmonary artery arises from the morphologic left ventricle." ; oboInOwl:hasDbXref "SNOMEDCT_US:204296002", "SNOMEDCT_US:26146002", "UMLS:C3536741" ; oboInOwl:hasExactSynonym "Transposition of great vessels" ; oboInOwl:id "HP:0001669" ; a owl:Class ; rdfs:label "Transposition of the great arteries" ; rdfs:subClassOf obo:HP_0011563, obo:HP_0011603 . obo:HP_0001670 obo:IAO_0000115 "Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray." ; oboInOwl:hasDbXref "UMLS:C0205700" ; oboInOwl:id "HP:0001670" ; a owl:Class ; rdfs:label "Asymmetric septal hypertrophy" ; rdfs:subClassOf obo:HP_0001639 . obo:HP_0001671 obo:IAO_0000115 "An anomaly of the intra-atrial or intraventricular septum." ; oboInOwl:hasAlternativeId "HP:0001690", "HP:0004760" ; oboInOwl:hasDbXref "MSH:D006343", "SNOMEDCT_US:253273004", "SNOMEDCT_US:396351009", "SNOMEDCT_US:59494005", "UMLS:C0018816" ; oboInOwl:hasExactSynonym "Abnormality of the cardiac septa", "Heart septal defect", "Septal defects" ; oboInOwl:id "HP:0001671" ; a owl:Class ; rdfs:label "Abnormal cardiac septum morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002099 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001673 obo:IAO_0100001 "HP:0001649" ; oboInOwl:id "HP:0001673" ; a owl:Class ; rdfs:label "obsolete Tachycardia (with pheochromocytoma)" ; owl:deprecated true . obo:HP_0001674 obo:IAO_0000115 "A congenital heart defect characterized by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect." ; oboInOwl:hasAlternativeId "HP:0001689", "HP:0006697" ; oboInOwl:hasDbXref "Fyler:1120" ; oboInOwl:hasExactSynonym "Atrioventricular canal", "Common atrioventricular canal", "Complete atrioventricular septal defect", "Complete common AV canal" ; oboInOwl:id "HP:0001674" ; a owl:Class ; rdfs:comment "The complete form of AVC shows an ostium primum atrial septal defect, a common atrioventricular valve and a variable deficiency of the interventricular septum inlet. CAVC can be classified into types A, B or C according to the morphology of the common atrioventricular valve." ; rdfs:label "Complete atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0006695 . obo:HP_0001675 obo:IAO_0100001 "HP:0011675" ; oboInOwl:id "HP:0001675" ; a owl:Class ; rdfs:label "obsolete Rhythm disturbances associated with pheochromocytoma" ; owl:deprecated true . obo:HP_0001676 obo:IAO_0100001 "HP:0001962" ; oboInOwl:id "HP:0001676" ; a owl:Class ; rdfs:label "obsolete Palpitations (with pheochromocytoma)" ; owl:deprecated true . obo:HP_0001677 obo:IAO_0000115 "Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia." ; oboInOwl:hasAlternativeId "HP:0004929", "HP:0005138" ; oboInOwl:hasDbXref "MSH:D003324", "SNOMEDCT_US:414024009", "SNOMEDCT_US:53741008", "UMLS:C1956346" ; oboInOwl:hasExactSynonym "Coronary atherosclerosis", "Coronary disease", "Plaque build-up in arteries supplying blood to heart" ; oboInOwl:id "HP:0001677" ; a owl:Class ; rdfs:comment "Coronary artery disease, also called atherosclerotic heart disease, is the result of atheromatous plaques within the coronary arteries leading to myocardial ischemia and infarction." ; rdfs:label "Coronary artery atherosclerosis" ; rdfs:subClassOf obo:HP_0002621, obo:HP_0006704, obo:HP_0100545 . obo:HP_0001678 obo:IAO_0000115 "Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles." ; oboInOwl:hasAlternativeId "HP:0001668", "HP:0005142", "HP:0006672" ; oboInOwl:hasDbXref "MSH:D054537", "SNOMEDCT_US:233917008", "UMLS:C0004245", "UMLS:C1841659" ; oboInOwl:hasExactSynonym "Interruption of electrical communication between upper and lower chambers of heart" ; oboInOwl:hasRelatedSynonym "Atrioventricular nodal disease" ; oboInOwl:id "HP:0001678" ; a owl:Class ; rdfs:label "Atrioventricular block" ; rdfs:subClassOf obo:HP_0005150, obo:HP_0012722 . obo:HP_0001679 obo:IAO_0000115 "An abnormality of the aorta." ; oboInOwl:hasAlternativeId "HP:0030963" ; oboInOwl:hasDbXref "Fyler:1453", "UMLS:C4025756" ; oboInOwl:hasExactSynonym "Abnormal aorta morphology", "Abnormality of the aorta" ; oboInOwl:id "HP:0001679" ; a owl:Class ; rdfs:label "Abnormal aortic morphology" ; rdfs:subClassOf obo:HP_0011004, obo:HP_0030962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000947 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001680 obo:IAO_0000115 "Coarctation of the aorta is a narrowing or constriction of a segment of the aorta." ; oboInOwl:hasDbXref "MSH:D001017", "SNOMEDCT_US:7305005", "UMLS:C0003492" ; oboInOwl:hasExactSynonym "Aortic coarctation", "Coarctation of the aorta", "Narrowing of aorta", "Narrowing of the aorta" ; oboInOwl:id "HP:0001680" ; a owl:Class ; rdfs:comment "Coarctation refers to a narrowing of the lumen of a vessel producing an obstruction to flow. Coarctation can occur in any region of the aorta. Coarctation of the aorta is often a discrete obstruction commonly located in the descending thoracic aorta. More specifically, it is usually located in the juxtaductal position immediately distal to the left-subclavian artery in a left-sided arch. The hallmark clinical finding in coarctation of the aorta is hypertension proximal to the lesion, with diminished blood pressure distal to the obstruction. Consequently, clinical diagnosis can be made by the presence of diminished lower extremity pulses, differences in timing between upper extremity central pulses (often brachial) and lower extremity central pulses (often femoral), or the presence of a supine arm-leg blood pressure gradient." ; rdfs:label "Coarctation of aorta" ; rdfs:subClassOf obo:HP_0001679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000947 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001681 obo:IAO_0000115 "Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia." ; oboInOwl:hasDbXref "MSH:D000787", "SNOMEDCT_US:194828000", "SNOMEDCT_US:225566008", "UMLS:C0002962" ; oboInOwl:id "HP:0001681" ; a owl:Class ; rdfs:label "Angina pectoris" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0001682 obo:IAO_0000115 "A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve." ; oboInOwl:hasDbXref "MSH:D001020", "SNOMEDCT_US:204368006", "UMLS:C0340375" ; oboInOwl:hasExactSynonym "Narrowing of blood vessel below aortic heart valve", "Subaortic stenosis" ; oboInOwl:id "HP:0001682" ; a owl:Class ; rdfs:comment "Narrowing of the left ventricle of the heart just below the aortic valve through which blood must pass on its way up into the aorta." ; rdfs:label "Subvalvular aortic stenosis" ; rdfs:subClassOf obo:HP_0011103 . obo:HP_0001683 obo:IAO_0000115 "Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and through the defect in the ventral wall." ; oboInOwl:hasDbXref "Fyler:0170", "Fyler:170", "MSH:D054083", "SNOMEDCT_US:78250005", "UMLS:C0013580" ; oboInOwl:id "HP:0001683" ; a owl:Class ; rdfs:comment "See Moss and Adams 'Heart Disease in Infants, Children and Adolescents' p1168. Ectopia cordis has a very poor prognosis. Ectopia cordis is generally divided into five types: cervical, cervicothoracic, thoracic, abdominal, and thoracicoabdominal. Ectopia cordis is rare (5-8 per million live births), but the two most common forms are thoracic (59%) and thoracicoabdominal (38%)." ; rdfs:label "Ectopia cordis" ; rdfs:subClassOf obo:HP_0004307 . obo:HP_0001684 obo:IAO_0000115 "A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum." ; oboInOwl:hasAlternativeId "HP:0200131" ; oboInOwl:hasDbXref "Fyler:2000", "ICD-10:Q21.1", "MSH:D006344", "SNOMEDCT_US:204315000", "UMLS:C0344724" ; oboInOwl:hasExactSynonym "Atrial septal defect, ostium secundum type", "Ostium secundum atrial septal defect", "Patent ostium secundum" ; oboInOwl:id "HP:0001684" ; a owl:Class ; rdfs:label "Secundum atrial septal defect" ; rdfs:subClassOf obo:HP_0001631 . obo:HP_0001685 obo:IAO_0000115 "Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts." ; oboInOwl:hasDbXref "UMLS:C0151654" ; oboInOwl:id "HP:0001685" ; a owl:Class ; rdfs:comment "Myocardial fibrosis disrupts the myocardial architecture, contributes to myocardial disarray, and determines mechanical, electrical, and vasomotor dysfunction, thus promoting the progression of cardiac diseases to heart failure." ; rdfs:label "Myocardial fibrosis" ; rdfs:subClassOf obo:HP_0001637 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001686 oboInOwl:hasDbXref "MSH:D001044", "SNOMEDCT_US:441913003", "SNOMEDCT_US:44564008", "UMLS:C0003564" ; oboInOwl:hasExactSynonym "Aphonia" ; oboInOwl:id "HP:0001686" ; a owl:Class ; rdfs:label "Loss of voice" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0001688 obo:IAO_0000115 "Bradycardia related to a mean resting sinus rate of less than 50 beats per minute." ; oboInOwl:hasAlternativeId "HP:0005137" ; oboInOwl:hasDbXref "Fyler:7013", "SNOMEDCT_US:49710005", "UMLS:C0085610" ; oboInOwl:id "HP:0001688" ; a owl:Class ; rdfs:label "Sinus bradycardia" ; rdfs:subClassOf obo:HP_0001662, obo:HP_0011702 . obo:HP_0001691 obo:IAO_0000115 "A type of subvalvular aortic stenosis resulting from thickening of the musculature of the interventricular septum, which results in obstruction to blood flow through the left-ventricular outflow tract." ; oboInOwl:hasDbXref "UMLS:C3887554" ; oboInOwl:hasExactSynonym "Muscular subaortic stenosis" ; oboInOwl:id "HP:0001691" ; a owl:Class ; rdfs:label "Muscular subvalvular aortic stenosis" ; rdfs:subClassOf obo:HP_0001682 . obo:HP_0001692 obo:IAO_0000115 "A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance." ; oboInOwl:hasDbXref "SNOMEDCT_US:17366009", "UMLS:C0085611", "UMLS:C4025755" ; oboInOwl:hasRelatedSynonym "Primary atrial arrhythmia" ; oboInOwl:id "HP:0001692" ; a owl:Class ; rdfs:label "Atrial arrhythmia" ; rdfs:subClassOf obo:HP_0005115 . obo:HP_0001693 obo:IAO_0000115 "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system." ; oboInOwl:hasDbXref "SNOMEDCT_US:442119001", "UMLS:C0232180" ; oboInOwl:id "HP:0001693" ; a owl:Class ; rdfs:label "Cardiac shunt" ; rdfs:subClassOf obo:HP_0011028 . obo:HP_0001694 obo:IAO_0000115 "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the right side of the heart to the left." ; oboInOwl:hasDbXref "SNOMEDCT_US:79692001", "UMLS:C0428871" ; oboInOwl:id "HP:0001694" ; a owl:Class ; rdfs:label "Right-to-left shunt" ; rdfs:subClassOf obo:HP_0001693 . obo:HP_0001695 obo:IAO_0000115 "An abrupt loss of heart function." ; oboInOwl:hasDbXref "MSH:D006323", "SNOMEDCT_US:397829000", "SNOMEDCT_US:410429000", "UMLS:C0018790" ; oboInOwl:hasExactSynonym "Heart stops beating" ; oboInOwl:id "HP:0001695" ; a owl:Class ; rdfs:label "Cardiac arrest" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0001696 obo:IAO_0000115 "A left-right reversal (or \"mirror reflection\") of the anatomical location of the major thoracic and abdominal organs." ; oboInOwl:hasDbXref "Fyler:0100", "Fyler:100", "MSH:D012857", "MSH:D059446", "SNOMEDCT_US:14821001", "SNOMEDCT_US:24614000", "SNOMEDCT_US:27317008", "SNOMEDCT_US:43876007", "UMLS:C0037221", "UMLS:C0266642" ; oboInOwl:hasExactSynonym "All organs on wrong side of body", "situs oppositus", "situs transversus" ; oboInOwl:hasRelatedSynonym "Situs inversus" ; oboInOwl:id "HP:0001696" ; a owl:Class ; rdfs:label "Situs inversus totalis" ; rdfs:subClassOf obo:HP_0001651, obo:HP_0011534 . obo:HP_0001697 obo:IAO_0000115 "An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery." ; oboInOwl:hasDbXref "Fyler:1900", "UMLS:C4025754" ; oboInOwl:hasExactSynonym "Abnormality of the pericardium" ; oboInOwl:id "HP:0001697" ; a owl:Class ; rdfs:label "Abnormal pericardium morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001698 obo:IAO_0000115 "Accumulation of fluid within the pericardium." ; oboInOwl:hasDbXref "Fyler:1940", "MSH:D010490", "SNOMEDCT_US:373945007", "UMLS:C0031039" ; oboInOwl:hasExactSynonym "Fluid around heart", "Pericardial effusions" ; oboInOwl:id "HP:0001698" ; a owl:Class ; rdfs:label "Pericardial effusion" ; rdfs:subClassOf obo:HP_0001697 . obo:HP_0001699 obo:IAO_0000115 "Rapid and unexpected death." ; oboInOwl:hasDbXref "MSH:D003645", "SNOMEDCT_US:26636000", "UMLS:C0011071" ; oboInOwl:id "HP:0001699" ; a owl:Class ; rdfs:label "Sudden death" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0001700 obo:IAO_0000115 "Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction)." ; oboInOwl:hasDbXref "SNOMEDCT_US:251061000", "UMLS:C1442837" ; oboInOwl:id "HP:0001700" ; a owl:Class ; rdfs:label "Myocardial necrosis" ; rdfs:subClassOf obo:HP_0001637 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001701 obo:IAO_0000115 "Inflammation of the sac-like covering around the heart (pericardium)." ; oboInOwl:hasDbXref "MSH:D010493", "SNOMEDCT_US:3238004", "UMLS:C0031046" ; oboInOwl:hasExactSynonym "Swelling or irritation of membrane around heart" ; oboInOwl:id "HP:0001701" ; a owl:Class ; rdfs:label "Pericarditis" ; rdfs:subClassOf obo:HP_0001697, obo:HP_0045073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002407 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001702 obo:IAO_0000115 "Any structural anomaly of the tricuspid valve." ; oboInOwl:hasAlternativeId "HP:0031440" ; oboInOwl:hasDbXref "EPCC:06.01.00", "UMLS:C4025753" ; oboInOwl:hasExactSynonym "Abnormality of the tricuspid valve" ; oboInOwl:id "HP:0001702" ; a owl:Class ; rdfs:label "Abnormal tricuspid valve morphology" ; rdfs:subClassOf obo:HP_0006705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001704 obo:IAO_0000115 "One or more of the leaflets (cusps) of the tricuspid valve bulges back into the right atrium upon contraction of the right ventricle." ; oboInOwl:hasDbXref "Fyler:1733", "MSH:D014263", "SNOMEDCT_US:253383003", "UMLS:C0040962" ; oboInOwl:id "HP:0001704" ; a owl:Class ; rdfs:label "Tricuspid valve prolapse" ; rdfs:subClassOf obo:HP_0001702 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001705 obo:IAO_0000115 "An obstruction to the forward flow of blood in the outflow tract of the right ventricle." ; oboInOwl:hasDbXref "MSH:D014694", "UMLS:C0035619" ; oboInOwl:hasExactSynonym "Right ventricular outlet obstruction" ; oboInOwl:id "HP:0001705" ; a owl:Class ; rdfs:label "Right ventricular outlet tract obstruction" ; rdfs:subClassOf obo:HP_0033118 . obo:HP_0001706 obo:IAO_0000115 "Diffuse thickening of the ventricular endocardium and by associated myocardial dysfunction" ; oboInOwl:hasDbXref "MSH:D004695", "SNOMEDCT_US:65457005", "UMLS:C0014117" ; oboInOwl:id "HP:0001706" ; a owl:Class ; rdfs:label "Endocardial fibroelastosis" ; rdfs:subClassOf obo:HP_0004306 . obo:HP_0001707 obo:IAO_0000115 "An abnormality of the right ventricle of the heart." ; oboInOwl:hasDbXref "Fyler:1820", "SNOMEDCT_US:253516002", "UMLS:C0344887" ; oboInOwl:hasExactSynonym "Abnormality of the right ventricle", "Right ventricular abnormality" ; oboInOwl:id "HP:0001707" ; a owl:Class ; rdfs:comment "The function of the right ventricle is to receive blood from the right atrium and to eject blood into the pulmonary artery." ; rdfs:label "Abnormal right ventricle morphology" ; rdfs:subClassOf obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002080 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001708 obo:IAO_0000115 "Reduced ability of the right ventricle to perform its function (to receive blood from the right atrium and to eject blood into the pulmonary artery), often leading to pitting peripheral edema, ascites, and hepatomegaly." ; oboInOwl:hasDbXref "MSH:D006333", "SNOMEDCT_US:128404006", "SNOMEDCT_US:367363000", "UMLS:C0235527", "UMLS:C2939447" ; oboInOwl:hasExactSynonym "Impaired right ventricular function", "Right ventricular impairment", "Right-sided heart failure" ; oboInOwl:id "HP:0001708" ; a owl:Class ; rdfs:label "Right ventricular failure" ; rdfs:subClassOf obo:HP_0033118 . obo:HP_0001709 obo:IAO_0000115 "Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them." ; oboInOwl:hasDbXref "SNOMEDCT_US:27885002", "UMLS:C0151517" ; oboInOwl:hasExactSynonym "Complete heart block" ; oboInOwl:hasRelatedSynonym "Third-degree heart block" ; oboInOwl:id "HP:0001709" ; a owl:Class ; rdfs:label "Third degree atrioventricular block" ; rdfs:subClassOf obo:HP_0001678 . obo:HP_0001710 obo:IAO_0000115 "A congenital malformation of the outflow tract of the heart. Conotruncal defects are thought to result from a disturbance of the outflow tract of the embryonic heart, and comprise truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, transposition of the great arteries, and double outlet right ventricle." ; oboInOwl:hasDbXref "UMLS:C1853238" ; oboInOwl:hasExactSynonym "Conotruncal heart defects" ; oboInOwl:id "HP:0001710" ; a owl:Class ; rdfs:label "Conotruncal defect" ; rdfs:subClassOf obo:HP_0011563, obo:HP_0011603 . obo:HP_0001711 obo:IAO_0000115 "Any structural abnormality of the left ventricle of the heart." ; oboInOwl:hasDbXref "Fyler:1810", "SNOMEDCT_US:253535002", "UMLS:C0344905" ; oboInOwl:hasExactSynonym "Abnormal heart left ventricle morphology", "Abnormality of the left ventricle", "Left ventricular abnormality" ; oboInOwl:id "HP:0001711" ; a owl:Class ; rdfs:label "Abnormal left ventricle morphology" ; rdfs:subClassOf obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001712 obo:IAO_0000115 "Enlargement or increased size of the heart left ventricle." ; oboInOwl:hasAlternativeId "HP:0005171" ; oboInOwl:hasDbXref "Fyler:3608", "MSH:D017379", "SNOMEDCT_US:55827005", "UMLS:C0149721" ; oboInOwl:hasExactSynonym "Heart left ventricle hypertrophy", "Left ventricular wall hypertrophy" ; oboInOwl:id "HP:0001712" ; a owl:Class ; rdfs:label "Left ventricular hypertrophy" ; rdfs:subClassOf obo:HP_0001711, obo:HP_0001714 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001713 obo:IAO_0000115 "An abnormality of a cardiac ventricle." ; oboInOwl:hasDbXref "UMLS:C4025752" ; oboInOwl:hasExactSynonym "Abnormality of cardiac ventricle" ; oboInOwl:id "HP:0001713" ; a owl:Class ; rdfs:label "Abnormal cardiac ventricle morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002082 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001714 obo:IAO_0000115 "Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy." ; oboInOwl:hasAlternativeId "HP:0005167" ; oboInOwl:hasDbXref "SNOMEDCT_US:266249003", "UMLS:C0340279" ; oboInOwl:id "HP:0001714" ; a owl:Class ; rdfs:label "Ventricular hypertrophy" ; rdfs:subClassOf obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000585 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001716 obo:IAO_0000115 "A disorder of the cardiac conduction system of the heart characterized by ventricular preexcitation due to the presence of an abnormal accessory atrioventricular electrical conduction pathway." ; oboInOwl:hasDbXref "MSH:D014927", "SNOMEDCT_US:74390002", "UMLS:C0043202" ; oboInOwl:id "HP:0001716" ; a owl:Class ; rdfs:label "Wolff-Parkinson-White syndrome" ; rdfs:subClassOf obo:HP_0004309 . obo:HP_0001717 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a coronary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:445512009", "UMLS:C1611184" ; oboInOwl:id "HP:0001717" ; a owl:Class ; rdfs:label "Coronary artery calcification" ; rdfs:subClassOf obo:HP_0003207, obo:HP_0006704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001621 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001718 obo:IAO_0000115 "An abnormal narrowing of the orifice of the mitral valve." ; oboInOwl:hasAlternativeId "HP:0005163" ; oboInOwl:hasDbXref "EPCC:06.02.92", "Fyler:1511", "ICD-10:Q23.2", "MSH:D008946", "SNOMEDCT_US:79619009", "UMLS:C0026269" ; oboInOwl:hasExactSynonym "Mitral valve stenosis" ; oboInOwl:id "HP:0001718" ; a owl:Class ; rdfs:label "Mitral stenosis" ; rdfs:subClassOf obo:HP_0031481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001719 obo:IAO_0000115 "Double outlet right ventricle (DORV) is a type of ventriculoarterial connection in which both great vessels arise entirely or predominantly from the right ventricle." ; oboInOwl:hasDbXref "Fyler:600", "Fyler:606", "MSH:D004310", "SNOMEDCT_US:7484005", "UMLS:C0013069" ; oboInOwl:hasExactSynonym "DORV", "Double-outlet right ventricle" ; oboInOwl:id "HP:0001719" ; a owl:Class ; rdfs:comment "During the development of the heart, the outflow tract initially connects exclusively with the primitive right ventricle and must undergo extensive remodelling to divide into a separate pulmonary artery and aorta; subsequently, there is continued remodelling to establish direct continuity from the left ventricle to the aorta. DORV encompasses a wide spectrum of anatomic arrangements and pathophysiologic disturbances. At one end of the spectrum, it mimics tetralogy of Fallot in the presence of pulmonary stenosis, or a large ventricular septal defect (VSD) in the absence of such stenosis. At the other end of the spectrum, it behaves like transposition of the great arteries with a VSD." ; rdfs:label "Double outlet right ventricle" ; rdfs:subClassOf obo:HP_0001710, obo:HP_0011723 . obo:HP_0001722 obo:IAO_0000115 "A form of heart failure characterized by elevated cardiac output. This may be seen in patients with heart failure and hyperthyroidism, anemia, pregnancy, arteriovenous fistulae, and others." ; oboInOwl:hasDbXref "UMLS:C0742747" ; oboInOwl:id "HP:0001722" ; a owl:Class ; rdfs:label "High-output congestive heart failure" ; rdfs:subClassOf obo:HP_0001635 . obo:HP_0001723 obo:IAO_0000115 "Restrictive left ventricular physiology is characterized by a pattern of ventricular filling in which increased stiffness of the myocardium causes ventricular pressure to rise precipitously with only small increases in volume, defined as restrictive ventricular physiology in the presence of normal or reduced diastolic volumes (of one or both ventricles), normal or reduced systolic volumes, and normal ventricular wall thickness." ; oboInOwl:hasAlternativeId "HP:0005130" ; oboInOwl:hasDbXref "MSH:D002313", "SNOMEDCT_US:415295002", "SNOMEDCT_US:90828009", "UMLS:C0007196" ; oboInOwl:id "HP:0001723" ; a owl:Class ; rdfs:comment "Historically, systolic function was said to be preserved in RCM, but is rare for contractility to be truly normal. Restrictive physiology can occur in patients with end-stage hypertrophic and DCM." ; rdfs:label "Restrictive cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0001724 obo:IAO_0100001 "HP:0004942" ; oboInOwl:id "HP:0001724" ; a owl:Class ; rdfs:label "obsolete Aortic dilatation" ; owl:deprecated true . obo:HP_0001726 oboInOwl:consider "HP:0001654" ; oboInOwl:id "HP:0001726" ; a owl:Class ; rdfs:label "obsolete Increased prevalence of valvular disease" ; owl:deprecated true . obo:HP_0001727 obo:IAO_0000115 "A cerebrovascular accident (stroke) that occurs because of thromboembolism." ; oboInOwl:hasDbXref "UMLS:C1112433" ; oboInOwl:id "HP:0001727" ; a owl:Class ; rdfs:label "Thromboembolic stroke" ; rdfs:subClassOf obo:HP_0001907 . obo:HP_0001730 obo:IAO_0000115 "A progressive form of hearing impairment." ; oboInOwl:hasAlternativeId "HP:0008590" ; oboInOwl:hasDbXref "UMLS:C1842138" ; oboInOwl:hasExactSynonym "Progressive hearing loss" ; oboInOwl:id "HP:0001730" ; a owl:Class ; rdfs:label "Progressive hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0001732 obo:IAO_0000115 "An abnormality of the pancreas." ; oboInOwl:hasDbXref "MSH:D010182", "SNOMEDCT_US:3855007", "UMLS:C0030286", "UMLS:C4025751" ; oboInOwl:hasExactSynonym "Abnormality of the pancreas" ; oboInOwl:hasRelatedSynonym "Pancreatic disease" ; oboInOwl:id "HP:0001732" ; a owl:Class ; rdfs:label "Abnormality of the pancreas" ; rdfs:subClassOf obo:HP_0002012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001733 obo:IAO_0000115 "The presence of inflammation in the pancreas." ; oboInOwl:hasDbXref "MSH:D010195", "SNOMEDCT_US:75694006", "UMLS:C0030305" ; oboInOwl:hasExactSynonym "Pancreatic inflammation" ; oboInOwl:id "HP:0001733" ; a owl:Class ; rdfs:label "Pancreatitis" ; rdfs:subClassOf obo:HP_0012091, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001734 obo:IAO_0000115 "A congenital anomaly in which the pancreas completely (or sometimes incompletely) encircles the second portion of duodenum and occasionally obstructs the more proximal duodenum." ; oboInOwl:hasDbXref "MSH:C536376", "SNOMEDCT_US:40315008", "UMLS:C0149955" ; oboInOwl:id "HP:0001734" ; a owl:Class ; rdfs:label "Annular pancreas" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0001735 obo:IAO_0000115 "A acute form of pancreatitis." ; oboInOwl:hasAlternativeId "HP:0004512" ; oboInOwl:hasDbXref "SNOMEDCT_US:197456007", "UMLS:C0001339" ; oboInOwl:hasExactSynonym "Acute pancreatic inflammation", "Pancreatitis, acute" ; oboInOwl:id "HP:0001735" ; a owl:Class ; rdfs:label "Acute pancreatitis" ; rdfs:subClassOf obo:HP_0001733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001737 obo:IAO_0000115 "A cyst of the pancreas that possess a lining of mucous epithelium." ; oboInOwl:hasDbXref "MSH:D010181", "SNOMEDCT_US:31258000", "UMLS:C0030283", "UMLS:C1860394" ; oboInOwl:hasExactSynonym "Pancreatic cysts" ; oboInOwl:hasRelatedSynonym "Multiple pancreatic cysts", "Pancreatic cyst" ; oboInOwl:id "HP:0001737" ; a owl:Class ; rdfs:comment "Pancreatic cysts are to be distinguished from pancreatic pseudocysts that do not possess a lining of mucous epithelium." ; rdfs:label "Pancreatic cysts" ; rdfs:subClassOf obo:HP_0012090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001738 obo:IAO_0000115 "Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes." ; oboInOwl:hasAlternativeId "HP:0002581", "HP:0004508", "HP:0004509" ; oboInOwl:hasDbXref "MSH:D010188", "SNOMEDCT_US:37992001", "SNOMEDCT_US:47367009", "UMLS:C0030293", "UMLS:C0267963" ; oboInOwl:hasExactSynonym "Inability to properly digest food due to lack of pancreatic digestive enzymes" ; oboInOwl:hasRelatedSynonym "Pancreatic insufficiency" ; oboInOwl:id "HP:0001738" ; a owl:Class ; rdfs:label "Exocrine pancreatic insufficiency" ; rdfs:subClassOf obo:HP_0012092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001739 obo:IAO_0000115 "A structural anomaly of the nasopharynx." ; oboInOwl:hasDbXref "UMLS:C4025750" ; oboInOwl:hasExactSynonym "Abnormality of the nasopharynx" ; oboInOwl:id "HP:0001739" ; a owl:Class ; rdfs:comment "The nasopharynx (nasal part of the pharynx) lies behind the nose and above the level of the soft palate." ; rdfs:label "Abnormal nasopharynx morphology" ; rdfs:subClassOf obo:HP_0000366, obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001728 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001741 obo:IAO_0000115 "The male foreskin cannot be fully retracted from the head of the penis." ; oboInOwl:hasDbXref "SNOMEDCT_US:253854008", "UMLS:C0345326" ; oboInOwl:id "HP:0001741" ; a owl:Class ; rdfs:label "Phimosis" ; rdfs:subClassOf obo:HP_0100587 . obo:HP_0001742 obo:IAO_0000115 "Reduced ability to pass air through the nasal cavity often leading to mouth breathing." ; oboInOwl:hasDbXref "MSH:D015508", "SNOMEDCT_US:232209000", "SNOMEDCT_US:267100006", "SNOMEDCT_US:68235000", "UMLS:C0027424", "UMLS:C0027429" ; oboInOwl:hasExactSynonym "Blockage of nose", "Nasal blockage", "Nasal obstruction", "Obstruction of nose", "Stuffy nose" ; oboInOwl:hasNarrowSynonym "Congestion of nose" ; oboInOwl:id "HP:0001742" ; a owl:Class ; rdfs:label "Nasal congestion" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001743 obo:IAO_0000115 "An abnormality of the spleen." ; oboInOwl:hasDbXref "UMLS:C4025749" ; oboInOwl:hasExactSynonym "Abnormality of the spleen" ; oboInOwl:id "HP:0001743" ; a owl:Class ; rdfs:comment "The spleen is an abdominal organ that functions as a member of the hematopoietic system and of the immune system." ; rdfs:label "Abnormality of the spleen" ; rdfs:subClassOf obo:HP_0002012, obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001744 obo:IAO_0000115 "Abnormal increased size of the spleen." ; oboInOwl:hasAlternativeId "HP:0001745", "HP:0006269" ; oboInOwl:hasDbXref "MSH:D013163", "SNOMEDCT_US:16294009", "UMLS:C0038002" ; oboInOwl:hasExactSynonym "Increased spleen size" ; oboInOwl:id "HP:0001744" ; a owl:Class ; rdfs:label "Splenomegaly" ; rdfs:subClassOf obo:HP_0003271, obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001746 obo:IAO_0000115 "Absence (aplasia) of the spleen." ; oboInOwl:hasDbXref "Fyler:4771", "SNOMEDCT_US:702624008", "SNOMEDCT_US:707147002", "SNOMEDCT_US:93030006", "UMLS:C0600031" ; oboInOwl:hasExactSynonym "Absent spleen" ; oboInOwl:id "HP:0001746" ; a owl:Class ; rdfs:label "Asplenia" ; rdfs:subClassOf obo:HP_0010451 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001747 obo:IAO_0000115 "An accessory spleen is a round, iso-echogenic, homogenic and smooth structure and is seen as a normal variant mostly on the medial contour of the spleen, near the hilus or around the lower pole. This has no pathogenic relevance." ; oboInOwl:hasDbXref "Fyler:4772", "SNOMEDCT_US:10362008", "UMLS:C0266631" ; oboInOwl:id "HP:0001747" ; a owl:Class ; rdfs:label "Accessory spleen" ; rdfs:subClassOf obo:HP_0009799 . obo:HP_0001748 obo:IAO_0000115 "Polysplenia is a congenital disease manifested by multiple small accessory spleens." ; oboInOwl:hasAlternativeId "HP:0001749", "HP:0006271", "HP:0006272" ; oboInOwl:hasDbXref "UMLS:C1856659" ; oboInOwl:hasExactSynonym "Accessory spleens", "Multiple accessory spleens", "Multiple small spleens" ; oboInOwl:id "HP:0001748" ; a owl:Class ; rdfs:label "Polysplenia" ; rdfs:subClassOf obo:HP_0009799 . obo:HP_0001750 obo:IAO_0000115 "The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle." ; oboInOwl:hasDbXref "Fyler:0200", "Fyler:200", "SNOMEDCT_US:45503006", "UMLS:C0152424" ; oboInOwl:hasExactSynonym "Common ventricle" ; oboInOwl:id "HP:0001750" ; a owl:Class ; rdfs:label "Single ventricle" ; rdfs:subClassOf obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001751 obo:IAO_0000115 "An abnormality of the functioning of the vestibular apparatus." ; oboInOwl:hasAlternativeId "HP:0006917", "HP:0007921" ; oboInOwl:hasDbXref "UMLS:C1843865" ; oboInOwl:hasExactSynonym "Impaired vestibular function", "Interictal vestibular dysfunction", "Vestibular function defect" ; oboInOwl:id "HP:0001751" ; a owl:Class ; rdfs:comment "The vestibular apparatus is the nonauditory portion of the inner ear that mediates the subjective sensation of motion and spatial orientation of the head, adjusts muscular activity and body position to maintain posture, and stabilizes in space the fixation point of the eyes when the head moves, in order to provide a stable image upon the retina. The functioning of the vestibular system is often checked clinically by means of the caloric test, in which the head is tilted backward by about 60 degrees and either warm or cold water is introduced into the external auditory meatus on one side. The immediate results are usually vertigo, nausea, nystagmus, and twisting of the head and body." ; rdfs:label "Abnormal vestibular function" ; rdfs:subClassOf obo:HP_0011389 . obo:HP_0001756 obo:IAO_0000115 "A general descriptive term that describes impaired functioning of the vestibular apparatus that leads to manifestations such as dizziness or postural imbalance" ; oboInOwl:hasDbXref "UMLS:C1848606" ; oboInOwl:hasExactSynonym "Vestibular deficiency", "Vestibular dysfunction", "Vestibular failure", "Vestibular hyporeflexia", "Vestibular loss", "Vestibulopathy" ; oboInOwl:id "HP:0001756" ; a owl:Class ; rdfs:label "Vestibular hypofunction" ; rdfs:subClassOf obo:HP_0001751 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001757 obo:IAO_0000115 "A form of sensorineural hearing impairment that affects primarily the higher frequencies." ; oboInOwl:hasDbXref "UMLS:C4021775" ; oboInOwl:hasExactSynonym "High frequency sensorineural hearing impairment", "High-tone sensorineural deafness", "High-tone sensorineural hearing impairment" ; oboInOwl:id "HP:0001757" ; a owl:Class ; rdfs:label "High-frequency sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0001760 obo:IAO_0000115 "An abnormality of the skeleton of foot." ; oboInOwl:hasAlternativeId "HP:0010216", "HP:0010611" ; oboInOwl:hasDbXref "MSH:D005530", "SNOMEDCT_US:229844004", "UMLS:C0016506" ; oboInOwl:hasExactSynonym "Abnormal feet structure", "Abnormality of the feet", "Abnormality of the foot", "Foot deformities", "Foot deformity" ; oboInOwl:id "HP:0001760" ; a owl:Class ; rdfs:comment "A disorder of the foot that can either be congenital or acquired. Such deformities can include hammer toe, club foot deformity, flat feet, pes cavus, congenital vertical talus (rocker bottom foot), and many others." ; rdfs:label "Abnormal foot morphology" ; rdfs:subClassOf obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001761 obo:IAO_0000115 "An increase in height of the medial longitudinal arch of the foot that does not flatten on weight bearing (i.e., a distinctly hollow form of the sole of the foot when it is bearing weight)." ; oboInOwl:hasAlternativeId "HP:0008075" ; oboInOwl:hasDbXref "MEDDRA:10034743", "SNOMEDCT_US:205091006", "UMLS:C0728829" ; oboInOwl:hasExactSynonym "Cavus foot", "High-arched foot" ; oboInOwl:id "HP:0001761" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pes cavus" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001762 obo:IAO_0000115 "Talipes equinovarus (also called clubfoot) typically has four main components: inversion and adduction of the forefoot; inversion of the heel and hindfoot; equinus (limitation of extension) of the ankle and subtalar joint; and internal rotation of the leg." ; oboInOwl:hasDbXref "Fyler:4171", "MEDDRA:10043106", "MSH:D003025", "SNOMEDCT_US:249808002", "SNOMEDCT_US:397932003", "UMLS:C0009081" ; oboInOwl:hasExactSynonym "Club feet", "Club foot", "Clubbing of feet", "Clubfeet", "Clubfoot", "Equinovarus", "Foot, talipes equinovarus", "Pes equinovarus", "Pes equinus", "Talipes varus" ; oboInOwl:id "HP:0001762" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Clubfoot is a complex, multifactorial deformity with genetic and intrauterine factors. One popular theory postulates that a clubfoot is a result of intrauterine maldevelopment of the talus that leads to adduction and plantarflexion of the foot. On radiographic projection a clubfoot can be noted as parallel axes of talus and calcaneus." ; rdfs:label "Talipes equinovarus" ; rdfs:subClassOf obo:HP_0001883 . obo:HP_0001763 obo:IAO_0000115 "A foot where the longitudinal arch of the foot is in contact with the ground or floor when the individual is standing; or, in a patient lying supine, a foot where the arch is in contact with the surface of a flat board pressed against the sole of the foot by the examiner with a pressure similar to that expected from weight bearing; or, the height of the arch is reduced." ; oboInOwl:hasDbXref "MSH:D005413", "SNOMEDCT_US:203534009", "SNOMEDCT_US:53226007", "UMLS:C0016202", "UMLS:C0264133" ; oboInOwl:hasExactSynonym "Flat feet", "Flat foot" ; oboInOwl:hasRelatedSynonym "Dropped arches", "Fallen arches" ; oboInOwl:id "HP:0001763" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pes planus" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001765 obo:IAO_0000115 "Hyperextension of the metatarsal-phalangeal joint with hyperflexion of the proximal interphalangeal (PIP) joint." ; oboInOwl:hasDbXref "MSH:D037801", "SNOMEDCT_US:122481008", "UMLS:C1136179" ; oboInOwl:hasExactSynonym "Hammer toe", "Hammertoe", "Hammertoes" ; oboInOwl:id "HP:0001765" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hammertoe" ; rdfs:subClassOf obo:HP_0034398 . obo:HP_0001769 obo:IAO_0000115 "A foot for which the measured width is above the 95th centile for age; or, a foot that appears disproportionately wide for its length." ; oboInOwl:hasDbXref "UMLS:C1866241" ; oboInOwl:hasExactSynonym "Broad feet", "Broad foot", "Wide foot" ; oboInOwl:id "HP:0001769" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad foot" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001770 obo:IAO_0000115 "Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\"." ; oboInOwl:hasAlternativeId "HP:0001828", "HP:0005677" ; oboInOwl:hasDbXref "SNOMEDCT_US:32113001", "UMLS:C0265660" ; oboInOwl:hasExactSynonym "Foot syndactyly", "Fused toes", "Syndactyly of feet", "Syndactyly of toes", "Webbed toes" ; oboInOwl:id "HP:0001770" ; a owl:Class ; rdfs:label "Toe syndactyly" ; rdfs:subClassOf obo:HP_0001159, obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001771 obo:IAO_0000115 "A contracture of the Achilles tendon." ; oboInOwl:hasAlternativeId "HP:0004711", "HP:0005031", "HP:0006430" ; oboInOwl:hasDbXref "SNOMEDCT_US:203076007", "UMLS:C0410264" ; oboInOwl:hasExactSynonym "Achilles tendon contractures", "Contractures of the Achilles tendon", "Shortening of the achilles tendon", "Tight achilles tendon" ; oboInOwl:id "HP:0001771" ; a owl:Class ; rdfs:label "Achilles tendon contracture" ; rdfs:subClassOf obo:HP_0005109, obo:HP_0008366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001772 obo:IAO_0000115 "A deformity of foot and ankle in which the foot is bent down and outwards." ; oboInOwl:hasDbXref "MSH:D004863", "SNOMEDCT_US:68284008", "UMLS:C0265642", "UMLS:C4020866" ; oboInOwl:hasRelatedSynonym "Equinovalgus deformity" ; oboInOwl:id "HP:0001772" ; a owl:Class ; rdfs:label "Talipes equinovalgus" ; rdfs:subClassOf obo:HP_0001883 . obo:HP_0001773 obo:IAO_0000115 "A measured foot length that is more than 2 SD below the mean for a newborn of 27 - 41 weeks gestation, or foot that is less than the 3rd centile for individuals from birth to 16 years of age (objective). Alternatively, a foot that appears disproportionately short (subjective)." ; oboInOwl:hasAlternativeId "HP:0001764", "HP:0001766", "HP:0001778", "HP:0008135" ; oboInOwl:hasDbXref "UMLS:C1848673" ; oboInOwl:hasExactSynonym "Hypoplastic feet", "Short feet", "Short foot", "Small feet" ; oboInOwl:id "HP:0001773" ; a owl:Class ; rdfs:label "Short foot" ; rdfs:subClassOf obo:HP_0006494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001775 oboInOwl:hasDbXref "UMLS:C4025748" ; oboInOwl:id "HP:0001775" ; a owl:Class ; rdfs:label "Tarsal osteovalgus" ; rdfs:subClassOf obo:HP_0008365 . obo:HP_0001776 obo:IAO_0000115 "Bilateral clubfoot deformity." ; oboInOwl:hasDbXref "UMLS:C1837835" ; oboInOwl:hasExactSynonym "Bilateral clubfeet", "Bilateral clubfoot", "Club foot on both sides" ; oboInOwl:id "HP:0001776" ; a owl:Class ; rdfs:label "Bilateral talipes equinovarus" ; rdfs:subClassOf obo:HP_0001762 . obo:HP_0001780 obo:IAO_0000115 "An anomaly of a toe." ; oboInOwl:hasDbXref "UMLS:C2674738" ; oboInOwl:hasExactSynonym "Abnormalities of the toes", "Abnormality of toe" ; oboInOwl:id "HP:0001780" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal toe morphology" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001782 obo:IAO_0000115 "An abnormality of the morphology of the toes, such that the tips of the toes are prominent and bulbous." ; oboInOwl:hasDbXref "UMLS:C4025747" ; oboInOwl:id "HP:0001782" ; a owl:Class ; rdfs:label "Bulbous tips of toes" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001831 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009778 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001783 obo:IAO_0000115 "Increased side-to-side width of a metatarsal bone." ; oboInOwl:hasAlternativeId "HP:0005907", "HP:0008106" ; oboInOwl:hasDbXref "UMLS:C1842231", "UMLS:C1850161" ; oboInOwl:hasExactSynonym "Wide long bone of foot" ; oboInOwl:hasRelatedSynonym "Broad metatarsals", "Widened metatarsal shaft" ; oboInOwl:id "HP:0001783" ; a owl:Class ; rdfs:label "Broad metatarsal" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001785 oboInOwl:hasDbXref "SNOMEDCT_US:26237000", "SNOMEDCT_US:267039000", "UMLS:C0235439" ; oboInOwl:hasExactSynonym "Ankle swelling" ; oboInOwl:id "HP:0001785" ; a owl:Class ; rdfs:label "Ankle swelling" ; rdfs:subClassOf obo:HP_0034673 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001851 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001786 obo:IAO_0000115 "A foot for which the measured width is below the 5th centile for age; or, a foot that appears disproportionately narrow for its length." ; oboInOwl:hasDbXref "SNOMEDCT_US:299464006", "UMLS:C0576227" ; oboInOwl:hasExactSynonym "Narrow foot", "Slender feet" ; oboInOwl:id "HP:0001786" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow foot" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001787 obo:IAO_0000115 "An abnormality of the birth process." ; oboInOwl:hasDbXref "SNOMEDCT_US:274127000", "UMLS:C0549629" ; oboInOwl:hasExactSynonym "Abnormal delivery", "Delivery complication" ; oboInOwl:id "HP:0001787" ; a owl:Class ; rdfs:label "Abnormal delivery" ; rdfs:subClassOf obo:HP_0001197 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001788 obo:IAO_0000115 "Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor." ; oboInOwl:hasAlternativeId "HP:0002163" ; oboInOwl:hasDbXref "MSH:D005322", "SNOMEDCT_US:237266003", "SNOMEDCT_US:44223004", "UMLS:C0015944" ; oboInOwl:id "HP:0001788" ; a owl:Class ; rdfs:label "Premature rupture of membranes" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0001789 obo:IAO_0000115 "The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema." ; oboInOwl:hasAlternativeId "HP:0005099" ; oboInOwl:hasDbXref "MSH:D015160", "SNOMEDCT_US:276508000", "UMLS:C0020305" ; oboInOwl:id "HP:0001789" ; a owl:Class ; rdfs:comment "The most common causes of hydrops fetalis are hematologic (inclusing isoimmunization because of Rhesus incompatibility and other causes), hereditary hemolytic disorders, fetal hemorrhage, disorders of red cell production), cardiovascular disorders, infections, certain intrathoracic malformations, and idiopathic forms." ; rdfs:label "Hydrops fetalis" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0034058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001790 obo:IAO_0000115 "A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens ." ; oboInOwl:hasDbXref "MSH:D015160", "SNOMEDCT_US:206538000", "SNOMEDCT_US:276509008", "UMLS:C0455988" ; oboInOwl:hasExactSynonym "Hydrops fetalis, non-immune", "Hydrops fetalis, nonimmune", "Non-immune fetal hydrops", "Non-immune foetal hydrops", "Nonimmune hydrops" ; oboInOwl:id "HP:0001790" ; a owl:Class ; rdfs:label "Nonimmune hydrops fetalis" ; rdfs:subClassOf obo:HP_0001789 . obo:HP_0001791 obo:IAO_0000115 "Accumulation of fluid in the peritoneal cavity during the fetal period." ; oboInOwl:hasDbXref "SNOMEDCT_US:363125002", "UMLS:C1285291" ; oboInOwl:hasExactSynonym "Foetal ascites" ; oboInOwl:id "HP:0001791" ; a owl:Class ; rdfs:label "Fetal ascites" ; rdfs:subClassOf obo:HP_0001541, obo:HP_0034207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000913 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001179 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000323 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001792 obo:IAO_0000115 "A nail that is diminished in length and width, i.e., underdeveloped nail." ; oboInOwl:hasAlternativeId "HP:0001813" ; oboInOwl:hasDbXref "SNOMEDCT_US:11375002", "UMLS:C0263523" ; oboInOwl:hasExactSynonym "Hypoplastic nail", "Hypoplastic nails", "Nail hypoplasia", "Small nail", "Small nails" ; oboInOwl:id "HP:0001792" ; a owl:Class ; rdfs:label "Small nail" ; rdfs:subClassOf obo:HP_0008386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001795 obo:IAO_0000115 "When viewed on end (with the digit tip pointing toward the examiner's eye) the curve of the nail forms a tighter curve of convexity." ; oboInOwl:hasAlternativeId "HP:0008413" ; oboInOwl:hasDbXref "SNOMEDCT_US:247487009", "UMLS:C0423807" ; oboInOwl:hasExactSynonym "Increased nail curvature", "Nail overcurvature" ; oboInOwl:id "HP:0001795" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "No objective standards were identified for this finding. Another way to describe this finding is to say that the observed curve has a smaller radius than does the typical nail. The affected digits should be specified." ; rdfs:label "Hyperconvex nail" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0001798 obo:IAO_0000115 "Aplasia of the nail." ; oboInOwl:hasAlternativeId "HP:0007593", "HP:0008384" ; oboInOwl:hasDbXref "MSH:C536377", "SNOMEDCT_US:23610003", "UMLS:C0265998" ; oboInOwl:hasExactSynonym "Absent nails", "Aplastic nails" ; oboInOwl:id "HP:0001798" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Total absence of nails." ; rdfs:label "Anonychia" ; rdfs:subClassOf obo:HP_0008386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001799 obo:IAO_0000115 "Decreased length of nail." ; oboInOwl:hasAlternativeId "HP:0200075" ; oboInOwl:hasDbXref "SNOMEDCT_US:247488004", "UMLS:C0423808" ; oboInOwl:hasExactSynonym "Short nail", "Short nails" ; oboInOwl:id "HP:0001799" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Use this designation when the length is reduced but the width is normal." ; rdfs:label "Short nail" ; rdfs:subClassOf obo:HP_0008386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001800 obo:IAO_0000115 "Underdevelopment of the toenail." ; oboInOwl:hasDbXref "UMLS:C1837279" ; oboInOwl:hasExactSynonym "Underdeveloped toenails" ; oboInOwl:id "HP:0001800" ; a owl:Class ; rdfs:label "Hypoplastic toenails" ; rdfs:subClassOf obo:HP_0001792, obo:HP_0010624 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001802 obo:IAO_0000115 "Congenital absence of the toenail." ; oboInOwl:hasDbXref "UMLS:C1844555" ; oboInOwl:hasExactSynonym "Absent toenail" ; oboInOwl:hasRelatedSynonym "Absent toenails", "Absent toenails (anonychia)", "Anonychia of toenails" ; oboInOwl:id "HP:0001802" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent toenail" ; rdfs:subClassOf obo:HP_0001798, obo:HP_0010624 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001803 obo:IAO_0000115 "Small (typically about 1 mm or less in size) depressions on the dorsal nail surface." ; oboInOwl:hasDbXref "MEDDRA:10028702", "SNOMEDCT_US:89704006", "UMLS:C0150993" ; oboInOwl:hasExactSynonym "Nail pits", "Nail pitting", "Pitted nails" ; oboInOwl:id "HP:0001803" ; oboInOwl:inSubset hp:secondary_consequence ; a owl:Class ; rdfs:label "Nail pits" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0001804 obo:IAO_0000115 "Underdevelopment of a fingernail." ; oboInOwl:hasDbXref "UMLS:C1856786" ; oboInOwl:hasExactSynonym "Small fingernail", "Underdeveloped fingernail" ; oboInOwl:id "HP:0001804" ; a owl:Class ; rdfs:label "Hypoplastic fingernail" ; rdfs:subClassOf obo:HP_0001231, obo:HP_0001792 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001805 obo:IAO_0000115 "Nail that appears thick when viewed on end." ; oboInOwl:hasAlternativeId "HP:0001819", "HP:0200088" ; oboInOwl:hasDbXref "SNOMEDCT_US:52897009", "UMLS:C0263537" ; oboInOwl:hasExactSynonym "Dystrophic thickened nails", "Thick nail", "Thickened nails" ; oboInOwl:id "HP:0001805" ; a owl:Class ; rdfs:comment "There is a build up of keratin causing the nail plate to lift away from the nail bed. The thickened nail plate is usually very hard. Onychauxis and onychogryposis are dystrophic diseases of the nail in which the nail plate becomes decidedly hypertrophied. The differentiation of the two entities is only one of degree of severity." ; rdfs:label "Onychogryposis" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001806 obo:IAO_0000115 "Detachment of the nail from the nail bed." ; oboInOwl:hasDbXref "MEDDRA:10030337", "MSH:D054039", "SNOMEDCT_US:75789001", "UMLS:C0085661" ; oboInOwl:hasExactSynonym "Detachment of nail", "Oncholysis" ; oboInOwl:id "HP:0001806" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Onycholysis" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001453 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001807 obo:IAO_0000115 "Longitudinal, linear prominences in the nail plate." ; oboInOwl:hasAlternativeId "HP:0001801", "HP:0001811" ; oboInOwl:hasDbXref "SNOMEDCT_US:271768001", "UMLS:C0423820" ; oboInOwl:hasExactSynonym "Grooved nails", "Longitudinal ridging", "Nail ridging" ; oboInOwl:hasRelatedSynonym "Ridged nails" ; oboInOwl:id "HP:0001807" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "There may be only one, or several ridges. The affected digits should be specified." ; rdfs:label "Ridged nail" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0001808 obo:IAO_0000115 "Nails that easily break." ; oboInOwl:hasAlternativeId "HP:0001796" ; oboInOwl:hasDbXref "UMLS:C1856963" ; oboInOwl:hasExactSynonym "Brittle nails" ; oboInOwl:id "HP:0001808" ; a owl:Class ; rdfs:label "Fragile nails" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001362 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001809 obo:IAO_0000115 "A nail plate that has a longitudinal separation and the two sections of the nail share the same lateral radius of curvature." ; oboInOwl:hasDbXref "SNOMEDCT_US:85136002", "UMLS:C0263530" ; oboInOwl:hasExactSynonym "Longitudinal splitting of nail" ; oboInOwl:id "HP:0001809" ; a owl:Class ; rdfs:comment "This is distinct from Fused nail, where the two parts of the nail have a separate radius of curvature. The affected digits should be specified as described in the introductory comments." ; rdfs:label "Split nail" ; rdfs:subClassOf obo:HP_0002164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001810 obo:IAO_0000115 "Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate." ; oboInOwl:hasAlternativeId "HP:0007558" ; oboInOwl:hasDbXref "UMLS:C1833225" ; oboInOwl:hasExactSynonym "Dystrophic toenail changes", "Poor toenail formation" ; oboInOwl:hasRelatedSynonym "Dystrophic toenails" ; oboInOwl:id "HP:0001810" ; a owl:Class ; rdfs:label "Dystrophic toenail" ; rdfs:subClassOf obo:HP_0008388, obo:HP_0008404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001812 obo:IAO_0000115 "When viewed on end (with the finger tip pointing toward the examiner's eye) the curve of the fingernail forms a tighter curve of convexity." ; oboInOwl:hasAlternativeId "HP:0008380" ; oboInOwl:hasDbXref "UMLS:C1844825" ; oboInOwl:hasExactSynonym "Tubular fingernails" ; oboInOwl:id "HP:0001812" ; a owl:Class ; rdfs:label "Hyperconvex fingernails" ; rdfs:subClassOf obo:HP_0001795 . obo:HP_0001814 obo:IAO_0000115 "Deeply placed nails." ; oboInOwl:hasDbXref "UMLS:C3277753" ; oboInOwl:hasExactSynonym "Deep-set nails" ; oboInOwl:id "HP:0001814" ; a owl:Class ; rdfs:label "Deep-set nails" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0001816 obo:IAO_0000115 "Nail that appears thin when viewed on end." ; oboInOwl:hasDbXref "SNOMEDCT_US:63829008", "UMLS:C0423823" ; oboInOwl:hasExactSynonym "Thin nail", "Thin nails" ; oboInOwl:id "HP:0001816" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "No objective standard for nail thickness could be identified. An unsupported claim suggests that nails are 0.5 mm in females and 0.6 mm in males. Thin nails are usually brittle, may easily fray, or break at the free edge. Thin nails usually grow slowly but this definition does not require slow growth of the nail. Note that the term koilonychia is an abnormal shape of the fingernail where the nail has raised ridges and is thin and concave. Since it indicates also other characteristics than thin nails, it should not be used to indicate this. The affected digits should be specified." ; rdfs:label "Thin nail" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001817 obo:IAO_0000115 "Absence of a fingernail." ; oboInOwl:hasDbXref "UMLS:C1844554" ; oboInOwl:hasExactSynonym "Absent fingernail", "Aplasia of the fingernail" ; oboInOwl:hasRelatedSynonym "Anonychia of fingernails" ; oboInOwl:id "HP:0001817" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent fingernail" ; rdfs:subClassOf obo:HP_0001798 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001818 obo:IAO_0000115 "The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia)." ; oboInOwl:hasDbXref "MEDDRA:10034016", "MSH:D010304", "SNOMEDCT_US:71906005", "UMLS:C0030578" ; oboInOwl:id "HP:0001818" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Paronychia" ; rdfs:subClassOf obo:HP_0100803 . obo:HP_0001820 obo:IAO_0000115 "White discoloration of the nails." ; oboInOwl:hasDbXref "MEDDRA:10050658", "SNOMEDCT_US:111202002", "UMLS:C0240182" ; oboInOwl:hasExactSynonym "White discoloration of nails" ; oboInOwl:id "HP:0001820" ; a owl:Class ; rdfs:label "Leukonychia" ; rdfs:subClassOf obo:HP_0100643 . obo:HP_0001821 obo:IAO_0000115 "Increased width of nail." ; oboInOwl:hasAlternativeId "HP:0008406" ; oboInOwl:hasDbXref "UMLS:C1843112" ; oboInOwl:hasExactSynonym "Broad fingernails", "Broad nail", "Wide fingernails" ; oboInOwl:id "HP:0001821" ; a owl:Class ; rdfs:label "Broad nail" ; rdfs:subClassOf obo:HP_0002164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001822 obo:IAO_0000115 "Lateral deviation of the great toe (i.e., in the direction of the little toe)." ; oboInOwl:hasAlternativeId "HP:0004682" ; oboInOwl:hasDbXref "MSH:D000071378", "MSH:D006215", "SNOMEDCT_US:122480009", "SNOMEDCT_US:415692008", "UMLS:C0006386", "UMLS:C0018536" ; oboInOwl:hasExactSynonym "Bunion", "Lateral deviation of great toe", "Lateral deviation of halluces" ; oboInOwl:id "HP:0001822" ; a owl:Class ; rdfs:label "Hallux valgus" ; rdfs:subClassOf obo:HP_0010051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001824 obo:IAO_0000115 "Reduction of total body weight." ; oboInOwl:hasDbXref "MSH:D015431", "SNOMEDCT_US:161832001", "SNOMEDCT_US:262285001", "SNOMEDCT_US:89362005", "UMLS:C1262477" ; oboInOwl:hasExactSynonym "Loss of weight" ; oboInOwl:id "HP:0001824" ; a owl:Class ; rdfs:label "Weight loss" ; rdfs:subClassOf obo:HP_0004325 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0001827 obo:IAO_0000115 "Congenital occlusion of a tube in the genital tract." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T04:08:00Z" ; oboInOwl:hasAlternativeId "HP:0001534" ; oboInOwl:hasDbXref "UMLS:C4025746" ; oboInOwl:id "HP:0001827" ; a owl:Class ; rdfs:label "Genital tract atresia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001829 obo:IAO_0000115 "A kind of polydactyly characterized by the presence of a supernumerary toe or toes." ; oboInOwl:hasAlternativeId "HP:0009135" ; oboInOwl:hasDbXref "SNOMEDCT_US:62218008", "UMLS:C0158734" ; oboInOwl:hasExactSynonym "Duplication of bones of the toes", "Polydactyly of feet", "Polydactyly of the foot" ; oboInOwl:id "HP:0001829" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Foot polydactyly" ; rdfs:subClassOf obo:HP_0001780, obo:HP_0009136, obo:HP_0010442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001830 obo:IAO_0000115 "Polydactyly of the foot most commonly refers to the presence of six toes on one foot. Postaxial polydactyly affects the lateral ray and the duplication may range from a well-formed articulated digit to a rudimentary digit." ; oboInOwl:hasAlternativeId "HP:0010346" ; oboInOwl:hasDbXref "UMLS:C2112129", "UMLS:C4020865" ; oboInOwl:hasExactSynonym "Extra toe attached near the little toe", "Polydactyly affecting the 5th toe", "Postaxial polydactyly of feet", "Postaxial polydactyly of foot", "Posterior polydactyly of foot" ; oboInOwl:hasRelatedSynonym "Fibular polydactyly" ; oboInOwl:id "HP:0001830" ; a owl:Class ; rdfs:comment "The modifier postaxial means that the supernumerary digit is not a hallux." ; rdfs:label "Postaxial foot polydactyly" ; rdfs:subClassOf obo:HP_0001829, obo:HP_0010322, obo:HP_0100259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003635 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001831 obo:IAO_0000115 "A toe that appears disproportionately short compared to the foot." ; oboInOwl:hasAlternativeId "HP:0001767", "HP:0001781", "HP:0001855", "HP:0004701", "HP:0005889", "HP:0008099" ; oboInOwl:hasDbXref "UMLS:C1836195" ; oboInOwl:hasExactSynonym "Brachydactyly of the foot", "Hypoplasia of the toe", "Hypoplastic toes", "Short foot phalanges", "Short toe", "Short toes", "Stubby toes" ; oboInOwl:id "HP:0001831" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding must be distinguished from digits that are of increased girth but of normal length and that of a long mid- and hind foot with normal digit lengths. The affected digits should be specified as described in the introductory comments. Note that we designate brachydactyly as a synonym, but this use of the term is distinct from the use of the same word in Bell's classification of brachdactyly." ; rdfs:label "Short toe" ; rdfs:subClassOf obo:HP_0001991, obo:HP_0011927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001832 obo:IAO_0000115 "Abnormalities of the metatarsal bones (i.e. of five tubular bones located between the tarsal bones of the hind- and mid-foot and the phalanges of the toes)." ; oboInOwl:hasDbXref "UMLS:C4025745" ; oboInOwl:hasExactSynonym "Abnormality of the long bone of foot" ; oboInOwl:id "HP:0001832" ; a owl:Class ; rdfs:label "Abnormal metatarsal morphology" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001833 obo:IAO_0000115 "Increased back to front length of the foot." ; oboInOwl:hasAlternativeId "HP:0008136", "HP:0008143" ; oboInOwl:hasDbXref "SNOMEDCT_US:299462005", "UMLS:C0576225" ; oboInOwl:hasExactSynonym "Disproportionately large feet", "Long foot", "large feet", "long feet" ; oboInOwl:id "HP:0001833" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long foot" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001836 obo:IAO_0000115 "Camptodactyly is a painless flexion contracture of the proximal interphalangeal (PIP) joint that is usually gradually progressive. This term refers to camptodactyly of one or more toes." ; oboInOwl:hasDbXref "UMLS:C4021774" ; oboInOwl:hasExactSynonym "Camptodactyly of feet" ; oboInOwl:id "HP:0001836" ; a owl:Class ; rdfs:label "Camptodactyly of toe" ; rdfs:subClassOf obo:HP_0005830, obo:HP_0012385 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007721 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001837 obo:IAO_0000115 "Visible increase in width of the non-hallux digit without an increase in the dorso-ventral dimension." ; oboInOwl:hasDbXref "UMLS:C1865038" ; oboInOwl:hasExactSynonym "Broad toe", "Wide toe" ; oboInOwl:id "HP:0001837" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that the girth may be increased in a broad toe, but this must be distinguished from Macrodactyly because in Macrodactyly the length is increased as well. The affected digit should be specified. Note that this assessment may be difficult when the toes are short. This term is not used for the first digit, see Broad hallux. If all five digits are broad, both terms should be used for that patient." ; rdfs:label "Broad toe" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001838 obo:IAO_0000115 "The presence of both a prominent heel and a convex contour of the sole." ; oboInOwl:hasAlternativeId "HP:0001835", "HP:0004693", "HP:0010218" ; oboInOwl:hasDbXref "MEDDRA:10066242", "MSH:C536345", "MSH:D005413", "SNOMEDCT_US:205082007", "SNOMEDCT_US:205359003", "UMLS:C0240912" ; oboInOwl:hasExactSynonym "Congenital vertical talus", "Rocker bottom feet", "Rocker bottom foot", "Rocker-bottom feet", "Rockerbottom feet" ; oboInOwl:id "HP:0001838" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Congenital vertical talus is characterized by pes valgus, a rigid flatfoot deformity (as opposed to a flexible calcaneovalgus foot) caused by a malpositioned navicular bone at the neck of the talus; the ankle is in severe equinus and the forefoot in dorsiflexion, rocker bottom-like, accompanied by contraction of the talonavicular, deltoid and calcaneal cuboidal ligaments. The foot examination usually reveals a rigid foot with a \"reversed\" arch, a convex plantar surface, and a deep crease on the lateral dorsal side of the foot. The ankle joint is plantarflexed, while the midfoot and forefoot are extended upward. Lateral foot radiographs are helpful in confirming the diagnosis." ; rdfs:label "Rocker bottom foot" ; rdfs:subClassOf obo:HP_0008365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001854 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001839 obo:IAO_0000115 "A condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet." ; oboInOwl:hasAlternativeId "HP:0003062", "HP:0005904" ; oboInOwl:hasDbXref "SNOMEDCT_US:205358006", "UMLS:C0432028" ; oboInOwl:hasExactSynonym "Foot ectrodactyly", "Lobster-claw foot deformity", "Split foot", "Split-foot" ; oboInOwl:id "HP:0001839" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Split foot" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0100257 . obo:HP_0001840 obo:IAO_0000115 "The metatarsals are deviated medially (tibially), that is, the bones in the front half of the foot bend or turn in toward the body." ; oboInOwl:hasAlternativeId "HP:0001768", "HP:0010217" ; oboInOwl:hasDbXref "MSH:D000070592", "SNOMEDCT_US:77599005", "UMLS:C0231791", "UMLS:C4082169" ; oboInOwl:hasExactSynonym "Forefoot varus", "Front half of foot turns inward", "Metatarsus adductovarsus", "Metatarsus varus" ; oboInOwl:hasRelatedSynonym "Intoe" ; oboInOwl:id "HP:0001840" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Metatarsus varus (adductus) is one of the most common foot deformities, that is defined as a transverse plane deformity in Lisfranc's (tarsometatarsal) joints in which the metatarsals are deviated medially. The relationship between talus and calcaneus is normal. On inspection the toes angle abruptly towards the midline, creating a C-shaped lateral foot border with a prominent styloid process of the 5th metatarsal. The result is that the forefoot is twisted inwards relative to the heel, so that the sole faces the midline." ; rdfs:label "Metatarsus adductus" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0001841 obo:IAO_0000115 "Duplication of all or part of the first ray." ; oboInOwl:hasAlternativeId "HP:0009607", "HP:0010050" ; oboInOwl:hasDbXref "MSH:C566632", "UMLS:C1866339", "UMLS:C2112942" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the phalanges of the big toe", "Polydactyly affecting the hallux", "Preaxial hallucal polydactyly", "Preaxial polydactyly of feet", "Preaxial polydactyly of foot", "Preaxial polydactyly of the feet", "Preaxial polydactyly, feet" ; oboInOwl:id "HP:0001841" ; a owl:Class ; rdfs:comment "This term applies for a wide variety of partial and/or complete duplications of the phalanges of the big toe (sometimes including the 1st metatarsal). A partial duplication can present itself on x-rays as a notched phalanx, bifid phalanx or a broadened phalanx. Polydactyly affecting the big toe is called preaxial or hallucal polydactyly of the feet." ; rdfs:label "Preaxial foot polydactyly" ; rdfs:subClassOf obo:HP_0001829, obo:HP_0001844, obo:HP_0100258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003631 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001842 oboInOwl:hasDbXref "UMLS:C4025744" ; oboInOwl:hasExactSynonym "Acroosteolysis of feet" ; oboInOwl:id "HP:0001842" ; a owl:Class ; rdfs:label "Foot acroosteolysis" ; rdfs:subClassOf obo:HP_0010177 . obo:HP_0001844 obo:IAO_0000115 "This term applies for all abnormalities of the big toe, also called hallux." ; oboInOwl:hasDbXref "UMLS:C4021773" ; oboInOwl:hasExactSynonym "Abnormalities of the hallux", "Abnormality of the big toe", "Abnormality of the hallux" ; oboInOwl:id "HP:0001844" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal hallux morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001845 obo:IAO_0000115 "Describes a foot digit resting on the dorsal surface of an adjacent digit when the foot is at rest. Initially clawing may be dynamic and only noticeable on walking. Over time the plantar plate tears, subluxation occurs at the metatarsophalangeal joint (MTPJ), and the deformity becomes permanent." ; oboInOwl:hasDbXref "SNOMEDCT_US:203541003", "UMLS:C0920299" ; oboInOwl:hasExactSynonym "Overlapping toe", "Overlapping toes", "Overriding toes" ; oboInOwl:hasRelatedSynonym "Crossover toe" ; oboInOwl:id "HP:0001845" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This descriptor is ordered depending on which toes are involved. The overriding toe is labeled, as specified in the introduction (item 3): e.g., T3,4. The ordering of the numbers specifies which toe is dorsal, i.e., with dorsum of the foot facing upward the toe on top is/are recorded first separated by a comma from the digit that is/are overlapped. Toes that are laterally deviated, but do not rest on top of adjacent toes should be coded as Clinodactyly." ; rdfs:label "Overlapping toe" ; rdfs:subClassOf obo:HP_0034398 . obo:HP_0001847 obo:IAO_0000115 "Increased length of the big toe." ; oboInOwl:hasAlternativeId "HP:0001867" ; oboInOwl:hasDbXref "UMLS:C1864375" ; oboInOwl:hasExactSynonym "Increased length of the hallux", "Large halluces", "Long big toe", "Long halluces" ; oboInOwl:id "HP:0001847" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long hallux" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0010511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001848 obo:IAO_0000115 "This is a postural deformity in which the foot is positioned up against the tibia. The heel (calcaneus) is positioned downward (that is, the ankle is flexed upward), and the heel is turned outward (valgus)." ; oboInOwl:hasAlternativeId "HP:0001774", "HP:0008120" ; oboInOwl:hasBroadSynonym "Foot and ankle bend up toward shin of leg" ; oboInOwl:hasDbXref "UMLS:C1860450" ; oboInOwl:hasExactSynonym "Calcaneovalgus", "Calcaneovalgus Foot", "Valgus position of the calcaneus" ; oboInOwl:id "HP:0001848" ; a owl:Class ; rdfs:comment "Calcaneovalgus deformity may be related to abnormal positioning of the foot in utero and can resolve spontaneously after birth." ; rdfs:label "Calcaneovalgus deformity" ; rdfs:subClassOf obo:HP_0008119, obo:HP_0008364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001849 obo:IAO_0000115 "A developmental defect resulting in the presence of fewer than the normal number of toes." ; oboInOwl:hasAlternativeId "HP:0001777" ; oboInOwl:hasDbXref "SNOMEDCT_US:249820005", "UMLS:C0426934" ; oboInOwl:hasExactSynonym "Missing toes", "Oligodactyly of feet" ; oboInOwl:id "HP:0001849" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Foot oligodactyly" ; rdfs:subClassOf obo:HP_0010760, obo:HP_0012165 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001466 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001850 obo:IAO_0000115 "An abnormality of the tarsus are the cluster of seven bones in the foot between the tibia and fibula and the metatarsus, including the calcaneus (heel) bone and the talus (ankle) bone." ; oboInOwl:hasDbXref "UMLS:C1862136" ; oboInOwl:hasExactSynonym "Abnormal ankle bones", "Abnormal tarsals" ; oboInOwl:id "HP:0001850" ; a owl:Class ; rdfs:label "Abnormality of the tarsal bones" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001852 obo:IAO_0000115 "A widely spaced gap between the first toe (the great toe) and the second toe." ; oboInOwl:hasDbXref "UMLS:C1840069" ; oboInOwl:hasExactSynonym "Gap between 1st and 2nd toes", "Gap between first and second toe", "Increased space between first and second toes", "Sandal gap between first and second toes", "Space between great toe and second toe", "Wide space between 1st, 2nd toes", "Wide space between first and second toes", "Wide-spaced big toe", "Widely spaced 1st-2nd toes", "Widely spaced first and second toes", "Widened gap 1st-2nd toes", "Widened gap first and second toe" ; oboInOwl:id "HP:0001852" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sandal gap" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0001853 oboInOwl:hasAlternativeId "HP:0005615" ; oboInOwl:hasDbXref "UMLS:C4021772" ; oboInOwl:hasExactSynonym "Bifid distal phalanges of toes", "Bifid terminal phalanx of toe", "Notched outermost bones of toes" ; oboInOwl:id "HP:0001853" ; a owl:Class ; rdfs:label "Bifid distal phalanx of toe" ; rdfs:subClassOf obo:HP_0009136 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001854 obo:IAO_0000115 "Gout affecting the Metatarsophalangeal joint of big toe." ; oboInOwl:hasDbXref "SNOMEDCT_US:67148009", "UMLS:C0221168" ; oboInOwl:hasExactSynonym "Gout of big toe" ; oboInOwl:id "HP:0001854" ; a owl:Class ; rdfs:label "Podagra" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0001997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001857 obo:IAO_0000115 "Short distance from the end of the toe to the most distal interphalangeal crease or distal interphalangeal joint flexion point, i.e., abnormally short distal phalanx of toe." ; oboInOwl:hasDbXref "UMLS:C4021771" ; oboInOwl:hasExactSynonym "Hypoplastic distal phalanges of feet", "Short outermost bone of toe" ; oboInOwl:id "HP:0001857" ; a owl:Class ; rdfs:comment "This term differs from Partial absence of the toe because in that term the phalanx must be missing, whereas here it may be small, but present. Relative shortening of the distal phalanges of the toes can be harder to assess than in the fingers, as they are normally quite short. Distal phalangeal lengths can be assessed subjectively by comparing that digit segment to the rest of the digit, to other normal digits in that patient, or to typical patients of that age or build." ; rdfs:label "Short distal phalanx of toe" ; rdfs:subClassOf obo:HP_0005035, obo:HP_0010185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001859 oboInOwl:hasAlternativeId "HP:0100236" ; oboInOwl:hasDbXref "UMLS:C4025743" ; oboInOwl:id "HP:0001859" ; a owl:Class ; rdfs:label "Distal foot symphalangism" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0100235, obo:HP_0100263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001862 obo:IAO_0100001 "HP:0006121" ; oboInOwl:id "HP:0001862" ; a owl:Class ; rdfs:label "obsolete Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet)" ; owl:deprecated true . obo:HP_0001863 obo:IAO_0000115 "Bending or curvature of a toe in the tibial direction (i.e., towards the big toe)." ; oboInOwl:hasBroadSynonym "Toe curvature" ; oboInOwl:hasDbXref "UMLS:C4021770", "UMLS:C4280587" ; oboInOwl:hasExactSynonym "Clinodactyly of feet" ; oboInOwl:id "HP:0001863" ; a owl:Class ; rdfs:label "Toe clinodactyly" ; rdfs:subClassOf obo:HP_0030084, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001864 obo:IAO_0000115 "Bending or curvature of a fifth toe in the tibial direction (i.e., towards the big toe)." ; oboInOwl:hasBroadSynonym "Curvature of the little toe", "Curvature of the pinkie toe", "Curvature of the pinky toe" ; oboInOwl:hasDbXref "UMLS:C4025741", "UMLS:C4280586" ; oboInOwl:id "HP:0001864" ; a owl:Class ; rdfs:label "Clinodactyly of the 5th toe" ; rdfs:subClassOf obo:HP_0001863, obo:HP_0010344 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001868 obo:IAO_0000115 "The spontaneous detachment of a foot from the body due to long standing pathology." ; oboInOwl:hasDbXref "UMLS:C4025740" ; oboInOwl:id "HP:0001868" ; a owl:Class ; rdfs:label "Autoamputation of foot" ; rdfs:subClassOf obo:HP_0001218, obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001218 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001869 obo:IAO_0000115 "The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot." ; oboInOwl:hasDbXref "UMLS:C1857953" ; oboInOwl:hasExactSynonym "Deep wrinkles in soles of feet" ; oboInOwl:id "HP:0001869" ; a owl:Class ; rdfs:label "Deep plantar creases" ; rdfs:subClassOf obo:HP_0100872 . obo:HP_0001870 oboInOwl:hasDbXref "UMLS:C4025739" ; oboInOwl:hasExactSynonym "Acroosteolysis of distal phalanges of feet" ; oboInOwl:id "HP:0001870" ; a owl:Class ; rdfs:label "Acroosteolysis of distal phalanges (feet)" ; rdfs:subClassOf obo:HP_0001842, obo:HP_0010189 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010189 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001871 obo:IAO_0000115 "An abnormality of the hematopoietic system." ; oboInOwl:hasAlternativeId "HP:0003135" ; oboInOwl:hasDbXref "MSH:D006402", "SNOMEDCT_US:191124002", "SNOMEDCT_US:34093004", "UMLS:C0018939", "UMLS:C0850715", "UMLS:C4020864" ; oboInOwl:hasExactSynonym "Abnormality of blood and blood-forming tissues", "Abnormality of the haematopoietic system", "Abnormality of the hematopoietic system", "Haematological abnormality", "Hematological abnormality" ; oboInOwl:hasRelatedSynonym "Hematologic disease" ; oboInOwl:id "HP:0001871" ; a owl:Class ; rdfs:comment "The hematopoietic system comprises the organs that are involved in the production of blood, primarily the bone marrow, spleen, tonsils, and lymph nodes." ; rdfs:label "Abnormality of blood and blood-forming tissues" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001872 obo:IAO_0000115 "An abnormality of platelets." ; oboInOwl:hasAlternativeId "HP:0004807", "HP:0005554" ; oboInOwl:hasDbXref "MSH:D013915", "SNOMEDCT_US:127566005", "SNOMEDCT_US:32942005", "UMLS:C0040015", "UMLS:C0151854", "UMLS:C4020863" ; oboInOwl:hasExactSynonym "Platelet abnormalities" ; oboInOwl:hasRelatedSynonym "Blood platelet disease", "Thrombasthenia" ; oboInOwl:id "HP:0001872" ; a owl:Class ; rdfs:comment "Platelets, also known as thrombocytes, are non-nucleated disk-shaped cells mainly involved in blood coagulation." ; rdfs:label "Abnormality of thrombocytes" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001873 obo:IAO_0000115 "A reduction in the number of circulating thrombocytes." ; oboInOwl:hasAlternativeId "HP:0001906", "HP:0004838", "HP:0008175", "HP:0008268", "HP:0008302" ; oboInOwl:hasDbXref "MSH:D013921", "SNOMEDCT_US:302215000", "SNOMEDCT_US:415116008", "UMLS:C0040034", "UMLS:C0392386" ; oboInOwl:hasExactSynonym "Low platelet count" ; oboInOwl:id "HP:0001873" ; a owl:Class ; rdfs:comment "Thrombocytopenia can be divided into three major causes; 1) low production of platelets in the bone marrow; 2) intravascular breakdown of thrombocytes; and 3) increased turnover of platelets in spleen or liver (extravascular)." ; rdfs:label "Thrombocytopenia" ; rdfs:subClassOf obo:HP_0011873 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001874 obo:IAO_0000115 "A neutrophil abnormality." ; oboInOwl:hasDbXref "SNOMEDCT_US:250274006", "UMLS:C0427515" ; oboInOwl:hasExactSynonym "Abnormality of neutrophil", "Abnormality of neutrophils", "Abnormality of polymorphonuclear neutrophils" ; oboInOwl:id "HP:0001874" ; a owl:Class ; rdfs:comment "Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections. They are myeloid granulocytes and their names is derived from the fact that their cytoplasm contains granules that stain with acidic dye as well as granules that stain with basic dye. Their nuclei consist of three to five lobes connected by slender threads of chromatin. Mature neutrophils live for approximately one day." ; rdfs:label "Abnormality of neutrophils" ; rdfs:subClassOf obo:HP_0001911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001875 obo:IAO_0000115 "An abnormally low number of neutrophils in the peripheral blood." ; oboInOwl:hasAlternativeId "HP:0005515", "HP:0005533" ; oboInOwl:hasDbXref "SNOMEDCT_US:165517008", "UMLS:C0853697" ; oboInOwl:hasExactSynonym "Low blood neutrophil count", "Low neutrophil count", "Neutropoenia", "Peripheral neutropenia" ; oboInOwl:id "HP:0001875" ; a owl:Class ; rdfs:comment "Mild neutropenia is defined as an absolute neutrophil count of less than 1500 cells per microliter of blood, moderate less than 1000 cells per microliter of blood and, and severe is less than 500 cells per microliter of blood." ; rdfs:label "Neutropenia" ; rdfs:subClassOf obo:HP_0011991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001876 obo:IAO_0000115 "An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets)." ; oboInOwl:hasDbXref "MSH:D010198", "SNOMEDCT_US:127034005", "UMLS:C0030312" ; oboInOwl:hasExactSynonym "Low blood cell count", "Pancytopaenia" ; oboInOwl:id "HP:0001876" ; a owl:Class ; rdfs:label "Pancytopenia" ; rdfs:subClassOf obo:HP_0012145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001877 obo:IAO_0000115 "Any structural abnormality of erythrocytes (red-blood cells)." ; oboInOwl:hasAlternativeId "HP:0010973" ; oboInOwl:hasDbXref "SNOMEDCT_US:12222001", "UMLS:C0391870", "UMLS:C4020862" ; oboInOwl:hasExactSynonym "Abnormality of erythrocytes", "Abnormality of red blood cells" ; oboInOwl:hasRelatedSynonym "Abnormality of erythroid lineage cell" ; oboInOwl:id "HP:0001877" ; a owl:Class ; rdfs:label "Abnormal erythrocyte morphology" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001878 obo:IAO_0000115 "A type of anemia caused by premature destruction of red blood cells (hemolysis)." ; oboInOwl:hasAlternativeId "HP:0001910", "HP:0004827", "HP:0004853", "HP:0004868", "HP:0005503" ; oboInOwl:hasDbXref "MSH:D000743", "SNOMEDCT_US:61261009", "UMLS:C0002878" ; oboInOwl:hasExactSynonym "Haemolytic anaemia", "Hemolytic anaemia", "Increased hemolysis" ; oboInOwl:id "HP:0001878" ; a owl:Class ; rdfs:comment "Normally, erythrocytes survive on average about 110-120 days. With hemolysis, the erythrocyte survival is shortened, and generally increased marrow activity results in a reticulocyte count." ; rdfs:label "Hemolytic anemia" ; rdfs:subClassOf obo:HP_0011895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001879 obo:IAO_0000115 "An abnormal count or structure of eosinophils." ; oboInOwl:hasDbXref "UMLS:C4025738" ; oboInOwl:hasExactSynonym "Abnormality of eosinophils" ; oboInOwl:id "HP:0001879" ; a owl:Class ; rdfs:comment "Eosinophils stain with acidophilic dyes including eosin red. They have a bilobed nucleus, are weakly phagocytic, and are involved in the immune defense against worms. Eosinophils are released into the peripheral blood in a phenotypically mature state, and are capable of undergoing activation and recruitment into tissues in response to appropriate stimuli, most notably cytokines interleukin-5 and the eotaxins. Eosinophils spend only a brief time in the peripheral blood (half-life of about 18 hours) before they migrate to the thymus or gastrointestinal tract, where they reside under homeostatic conditions. In response to inflammatory stimuli, eosinophils develop from committed bone marrow progenitors, after which they exit, migrate into the blood and subsequently accumulate in peripheral tissues where survival is prolonged." ; rdfs:label "Abnormal eosinophil morphology" ; rdfs:subClassOf obo:HP_0001911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001880 obo:IAO_0000115 "Increased count of eosinophils in the blood." ; oboInOwl:hasDbXref "MSH:D004802", "UMLS:C0014457" ; oboInOwl:hasExactSynonym "High blood eosinophil count" ; oboInOwl:id "HP:0001880" ; a owl:Class ; rdfs:label "Eosinophilia" ; rdfs:subClassOf obo:HP_0001974, obo:HP_0020064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001881 obo:IAO_0000115 "An abnormality of leukocytes." ; oboInOwl:hasDbXref "SNOMEDCT_US:134199001", "SNOMEDCT_US:24827003", "UMLS:C0152009" ; oboInOwl:hasExactSynonym "Abnormality of leukocytes" ; oboInOwl:id "HP:0001881" ; a owl:Class ; rdfs:comment "Leukocytes are nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue." ; rdfs:label "Abnormal leukocyte morphology" ; rdfs:subClassOf obo:HP_0001871, obo:HP_0010987 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001882 obo:IAO_0000115 "An abnormal decreased number of leukocytes in the blood." ; oboInOwl:hasDbXref "MSH:D007970", "SNOMEDCT_US:84828003", "UMLS:C0023530" ; oboInOwl:hasExactSynonym "Decreased blood leukocyte number", "Low white blood cell count" ; oboInOwl:id "HP:0001882" ; a owl:Class ; rdfs:label "Leukopenia" ; rdfs:subClassOf obo:HP_0011893 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001883 obo:IAO_0000115 "A deformity of foot and ankle that has different subtypes that are talipes equinovarus, talipes equinovalgus, talipes calcaneovarus and talipes calcaneovalgus." ; oboInOwl:hasDbXref "MSH:D000070558", "SNOMEDCT_US:398309008", "UMLS:C1301937", "UMLS:C3552713" ; oboInOwl:hasRelatedSynonym "Talipes foot deformities" ; oboInOwl:id "HP:0001883" ; a owl:Class ; rdfs:comment """Talipes means (a deformity of) foot and ankle. There are four types of talipes. 1) Talipes equinovarus - the foot is pointing inwards and down (the most common form) 2) Talipes equinovalgus - where the foot points outwards and down 3) Talipes calcaneovarus - where the foot points inwards and up 4) Talipes calcaneovalgus - where the foot points inwards and down.""" ; rdfs:label "Talipes" ; rdfs:subClassOf obo:HP_0005656 . obo:HP_0001884 obo:IAO_0000115 "Talipes calcaneovalgus is a flexible foot deformity (as opposed to a rigid congenital vertical talus foot deformity) that can either present as a positional or structural foot deformity depending on severity and/or causality. The axis of calcaneovalgus deformity is in the tibiotalar joint, where the foot is positioned in extreme hyperextension. On inspection, the foot has an \"up and out\" appearance, with the dorsal forefoot practically touching the anterior aspect of the ankle and lower leg." ; oboInOwl:hasDbXref "MSH:D005413", "SNOMEDCT_US:205083002", "SNOMEDCT_US:31668003", "UMLS:C0152237" ; oboInOwl:hasExactSynonym "Pes calcaneovarus" ; oboInOwl:id "HP:0001884" ; a owl:Class ; rdfs:label "Talipes calcaneovalgus" ; rdfs:subClassOf obo:HP_0001883 . obo:HP_0001885 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the second toe." ; oboInOwl:hasDbXref "UMLS:C4021769" ; oboInOwl:hasExactSynonym "Short second toe" ; oboInOwl:id "HP:0001885" ; a owl:Class ; rdfs:label "Short 2nd toe" ; rdfs:subClassOf obo:HP_0001831 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001886 obo:IAO_0000115 "An infection of bone of the foot." ; oboInOwl:hasDbXref "UMLS:C4025737" ; oboInOwl:hasExactSynonym "Foot bone infection" ; oboInOwl:id "HP:0001886" ; a owl:Class ; rdfs:label "Foot osteomyelitis" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0002754 . obo:HP_0001888 obo:IAO_0000115 "A reduced number of lymphocytes in the blood." ; oboInOwl:hasDbXref "MSH:D008231", "SNOMEDCT_US:48813009", "UMLS:C0024312" ; oboInOwl:hasExactSynonym "Absolute lymphocyte count decrease", "Decreased blood lymphocyte number", "Low lymphocyte number", "Lymphocytopenia" ; oboInOwl:id "HP:0001888" ; a owl:Class ; rdfs:label "Lymphopenia" ; rdfs:subClassOf obo:HP_0040088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001889 obo:IAO_0000115 "Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts)." ; oboInOwl:hasAlternativeId "HP:0004858" ; oboInOwl:hasDbXref "MSH:D000749", "SNOMEDCT_US:53165003", "UMLS:C0002888" ; oboInOwl:hasExactSynonym "Megaloblastic anaemia" ; oboInOwl:id "HP:0001889" ; a owl:Class ; rdfs:comment "Megaloblastic anemia can result from folic acid deficiency or vitamin B12 deficiency. Folate deficiency leads to an impairment of DNA synthesis such that the cell cycle cannot progress from the G2 growth stage to the mitosis stage, in turn leading to continuing cell growth without division, which presents as macrocytosis." ; rdfs:label "Megaloblastic anemia" ; rdfs:subClassOf obo:HP_0001972 . obo:HP_0001890 obo:IAO_0000115 "An autoimmune form of hemolytic anemia." ; oboInOwl:hasDbXref "MSH:D000744", "SNOMEDCT_US:413603009", "UMLS:C0002880" ; oboInOwl:hasExactSynonym "Autoimmune haemolytic anaemia", "Autoimmune hemolytic anaemia", "Hemolytic anemia, autoimmune" ; oboInOwl:id "HP:0001890" ; a owl:Class ; rdfs:label "Autoimmune hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878, obo:HP_0002960 . obo:HP_0001891 oboInOwl:hasDbXref "MSH:D018798", "SNOMEDCT_US:87522002", "UMLS:C0162316" ; oboInOwl:hasExactSynonym "Ferropenic", "Iron deficiency anaemia", "Iron-deficiency anaemia", "Iron-deficiency anemia" ; oboInOwl:id "HP:0001891" ; a owl:Class ; rdfs:label "Iron deficiency anemia" ; rdfs:subClassOf obo:HP_0001931 . obo:HP_0001892 obo:IAO_0000115 "An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects." ; oboInOwl:hasAlternativeId "HP:0004830", "HP:0004834", "HP:0004849", "HP:0004862", "HP:0004865", "HP:0008183" ; oboInOwl:hasDbXref "SNOMEDCT_US:248250000", "SNOMEDCT_US:64779008", "UMLS:C1458140" ; oboInOwl:hasExactSynonym "Bleeding diathesis", "Bleeding tendency", "Hemorrhagic diathesis" ; oboInOwl:id "HP:0001892" ; a owl:Class ; rdfs:comment "This term is kept for historical reasons. If possible, a more exact description of the phenotype (i.e., whether there is a vascular, platelet and coagulation defect) should be attempted." ; rdfs:label "Abnormal bleeding" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001894 obo:IAO_0000115 "Increased numbers of platelets in the peripheral blood." ; oboInOwl:hasDbXref "MSH:D013922", "SNOMEDCT_US:415115007", "SNOMEDCT_US:6631009", "UMLS:C0836924", "UMLS:C0857460" ; oboInOwl:hasExactSynonym "Increased number of platelets in blood", "Increased platelet count" ; oboInOwl:hasRelatedSynonym "Thrombocythaemia", "Thrombocythemia" ; oboInOwl:id "HP:0001894" ; a owl:Class ; rdfs:comment "Thrombocythemia and thrombocytosis are conditions with a higher than normal number of platelets. The term \"thrombocythemia\" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia." ; rdfs:label "Thrombocytosis" ; rdfs:subClassOf obo:HP_0011873 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000233 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001895 oboInOwl:hasDbXref "UMLS:C0235983" ; oboInOwl:hasExactSynonym "Normochromic anaemia" ; oboInOwl:id "HP:0001895" ; a owl:Class ; rdfs:label "Normochromic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001896 obo:IAO_0000115 "A reduced number of reticulocytes in the peripheral blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:124961001", "UMLS:C0858867" ; oboInOwl:id "HP:0001896" ; a owl:Class ; rdfs:label "Reticulocytopenia" ; rdfs:subClassOf obo:HP_0004312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000558 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001897 obo:IAO_0000115 "A kind of anemia in which the volume of the red blood cells is normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:300980002", "UMLS:C0085577" ; oboInOwl:hasExactSynonym "Normocytic anaemia" ; oboInOwl:id "HP:0001897" ; a owl:Class ; rdfs:comment "In normocytic anemia, the mean corpuscular volume (MCV) is within normal limits (80-100 fl in adults)." ; rdfs:label "Normocytic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001898 obo:IAO_0000115 "The presence of an increased mass of red blood cells in the circulation." ; oboInOwl:hasDbXref "UMLS:C1853288" ; oboInOwl:hasExactSynonym "Increased RBC mass" ; oboInOwl:id "HP:0001898" ; a owl:Class ; rdfs:label "Increased red blood cell mass" ; rdfs:subClassOf obo:HP_0001901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000764 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001899 obo:IAO_0000115 "An elevation above the normal ratio of the volume of red blood cells to the total volume of blood." ; oboInOwl:hasDbXref "UMLS:C0239935" ; oboInOwl:hasExactSynonym "Increased Hct" ; oboInOwl:id "HP:0001899" ; a owl:Class ; rdfs:label "Increased hematocrit" ; rdfs:subClassOf obo:HP_0031850 . obo:HP_0001900 oboInOwl:hasDbXref "SNOMEDCT_US:131141003", "UMLS:C0549448" ; oboInOwl:hasExactSynonym "Increased Hb", "Increased haemoglobin" ; oboInOwl:id "HP:0001900" ; a owl:Class ; rdfs:label "Increased hemoglobin" ; rdfs:subClassOf obo:HP_0001901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_35143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001901 obo:IAO_0000115 "Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal." ; oboInOwl:hasAlternativeId "HP:0001893" ; oboInOwl:hasDbXref "MSH:D011086", "SNOMEDCT_US:109992005", "SNOMEDCT_US:127062003", "UMLS:C0032461", "UMLS:C1527405" ; oboInOwl:hasExactSynonym "Abnormally shaped erythrocytes", "Erythrocytosis", "Increased red blood cells", "Polyglobulia" ; oboInOwl:id "HP:0001901" ; a owl:Class ; rdfs:label "Polycythemia" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000081 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001902 obo:IAO_0000115 "Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998)." ; oboInOwl:hasDbXref "SNOMEDCT_US:44687006", "UMLS:C0333864" ; oboInOwl:id "HP:0001902" ; a owl:Class ; rdfs:comment "This phenotype may be present in myelodysplastic or myeloproliferative diseases and autoimmune thrombocytopenia (associated with severe leukemoid reactions). It may also be present in inherited diseases such as Bernard-Soulier syndrome or May-Hegglin anomaly." ; rdfs:label "Giant platelets" ; rdfs:subClassOf obo:HP_0011877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001940 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001903 obo:IAO_0000115 "A reduction in erythrocytes volume or hemoglobin concentration." ; oboInOwl:hasAlternativeId "HP:0001926", "HP:0003136", "HP:0005509" ; oboInOwl:hasDbXref "MSH:D000740", "SNOMEDCT_US:165397008", "SNOMEDCT_US:271737000", "UMLS:C0002871", "UMLS:C0162119" ; oboInOwl:hasExactSynonym "Anaemia", "Low number of red blood cells or haemoglobin", "Low number of red blood cells or hemoglobin" ; oboInOwl:hasRelatedSynonym "Decreased haemoglobin", "Decreased hemoglobin" ; oboInOwl:id "HP:0001903" ; a owl:Class ; rdfs:comment "Anemia is not a specific entity but can result from many underlying pathologic processes. The three main causes of anemia are blood loss, decreased or faulty red blood cell production, and increased destruction of red blood cells. Various classifications are in clinical use including a classification according to the mean corpuscular volume (MCV) of the erythrocytes: microcytic, macrocytic, or normocytic. Anemias can also be classified according to variations in cell size and shape, as reflected by the red-cell distribution width (RDW). Additionally, anemias can be classified into those of inadequate production and hemolytic anemias." ; rdfs:label "Anemia" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:unionOf ([ a owl:Class ; owl:intersectionOf (obo:PATO_0000596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] ) ] [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_35143 ] ) ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001904 obo:IAO_0000115 "A type of neutropenia that is observed in the presence of granulocyte-specific antibodies." ; oboInOwl:hasDbXref "SNOMEDCT_US:234425008", "UMLS:C0340971" ; oboInOwl:hasExactSynonym "Autoimmune neutropenia" ; oboInOwl:id "HP:0001904" ; a owl:Class ; rdfs:comment "The antibodies are directed against the cell surface membrane and have no relationship with antineutrophil cytoplasmic antibodies (ANCAs) in the vast majority of cases. It is important to highlight that there are frequent difficulties in the detection of autoantibodies causing AIN due to the labile nature of granulocytes (not storable without activation and consequent autolysis). This type of neutropenia is commonly seen with autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (Fc-gamma-IIIb receptor), causing their peripheral destruction." ; rdfs:label "Neutropenia in presence of anti-neutropil antibodies" ; rdfs:subClassOf obo:HP_0001875, obo:HP_0002960 . obo:HP_0001905 obo:IAO_0000115 "Thrombocytopenia with congenital onset." ; oboInOwl:hasAlternativeId "HP:0004869" ; oboInOwl:hasDbXref "UMLS:C0272278" ; oboInOwl:hasExactSynonym "thrombocytopenia, congenital" ; oboInOwl:id "HP:0001905" ; a owl:Class ; rdfs:label "Congenital thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0001907 obo:IAO_0000115 "The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site." ; oboInOwl:hasDbXref "MSH:D013923", "MSH:D016769", "SNOMEDCT_US:13713005", "SNOMEDCT_US:371039008", "UMLS:C0040038", "UMLS:C0085307" ; oboInOwl:hasExactSynonym "Blood clot in blood vessel", "Thromboembolic disease", "Thromboembolic events" ; oboInOwl:hasRelatedSynonym "Embolism and thrombosis" ; oboInOwl:id "HP:0001907" ; a owl:Class ; rdfs:label "Thromboembolism" ; rdfs:subClassOf obo:HP_0001977 . obo:HP_0001908 obo:IAO_0000115 "Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia." ; oboInOwl:hasDbXref "MSH:D000741", "SNOMEDCT_US:167923006", "SNOMEDCT_US:41614006", "UMLS:C0178416" ; oboInOwl:hasExactSynonym "Hypoplastic anaemia" ; oboInOwl:id "HP:0001908" ; a owl:Class ; rdfs:label "Hypoplastic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001909 obo:IAO_0000115 "A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes." ; oboInOwl:hasAlternativeId "HP:0005519", "HP:0006726" ; oboInOwl:hasBroadSynonym "Blood cancer" ; oboInOwl:hasDbXref "MSH:D007938", "MSH:D019337", "SNOMEDCT_US:129154003", "SNOMEDCT_US:269475001", "SNOMEDCT_US:87163000", "SNOMEDCT_US:93143009", "UMLS:C0023418", "UMLS:C0376545" ; oboInOwl:hasExactSynonym "Leukaemia" ; oboInOwl:id "HP:0001909" ; a owl:Class ; rdfs:label "Leukemia" ; rdfs:subClassOf obo:HP_0001881, obo:HP_0004377 . obo:HP_0001911 obo:IAO_0000115 "Any structural abnormality or abnormal count of granulocytes." ; oboInOwl:hasAlternativeId "HP:0005438" ; oboInOwl:hasDbXref "SNOMEDCT_US:250274006", "UMLS:C0427515" ; oboInOwl:hasExactSynonym "Abnormality of granulocytes" ; oboInOwl:id "HP:0001911" ; a owl:Class ; rdfs:label "Abnormal granulocyte morphology" ; rdfs:subClassOf obo:HP_0010974 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001912 obo:IAO_0000115 "Any structural abnormality or abnormal count of basophils." ; oboInOwl:hasDbXref "UMLS:C4025736" ; oboInOwl:hasExactSynonym "Abnormality of basophils" ; oboInOwl:id "HP:0001912" ; a owl:Class ; rdfs:comment "Basophils are myeoloid granulocytes and part of the innate immune system. They represent the least abundant granulocyte population in mammals. They have a complex, almost C-shaped nucleus. Their granules stain blue with basic dye. They are not phagacytic. They are involved in the immune response to worms. Their cell surface has Fc receptors which may be attached to class E antibodies." ; rdfs:label "Abnormal basophil morphology" ; rdfs:subClassOf obo:HP_0001911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001913 obo:IAO_0000115 "An abnormally reduced number of granulocytes in the blood." ; oboInOwl:hasDbXref "MSH:D000380", "SNOMEDCT_US:17182001", "SNOMEDCT_US:417672002", "UMLS:C0001824" ; oboInOwl:id "HP:0001913" ; a owl:Class ; rdfs:label "Granulocytopenia" ; rdfs:subClassOf obo:HP_0032309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001915 obo:IAO_0000115 "Aplastic anemia is defined as pancytopenia with a hypocellular marrow." ; oboInOwl:hasDbXref "MSH:D000741", "SNOMEDCT_US:304132006", "SNOMEDCT_US:306058006", "UMLS:C0002874" ; oboInOwl:hasExactSynonym "Aplastic anaemia" ; oboInOwl:id "HP:0001915" ; a owl:Class ; rdfs:comment "Aplastic anemia is characterized by reduced numbers of all blood cell types (red blood cells, white blood cells, and platelets) owing to reduced production." ; rdfs:label "Aplastic anemia" ; rdfs:subClassOf obo:HP_0001876 . obo:HP_0001917 obo:IAO_0000115 "A form of amyloidosis that affects the kidney. On hematoxylin and eosin stain, amyloid is identified as extracellular amorphous material that is lightly eosinophilic. These deposits often stain weakly for periodic acid Schiff (PAS), demonstrate a blue-to-gray hue on the trichrome stain and are typically negative on the Jones methenamine silver (JMS) stain. These tinctorial properties contrast with the histologic appearance of collagen, a major component of basement membranes, mesangial matrix and areas of sclerosis, which demonstrates strong positivity for PAS and JMS (See Figure 1 of PMID:25852856)." ; oboInOwl:hasDbXref "SNOMEDCT_US:48713002", "UMLS:C0268382" ; oboInOwl:id "HP:0001917" ; a owl:Class ; rdfs:comment "In the kidney, amyloid deposits may be found in any of the parenchymal compartments, including glomeruli, tubules, interstitium and/or vessels. Glomeruli are most commonly involved. In most instances, amyloid accumulation involves the mesangium before the capillary walls. In early cases, the process can be subtle and involves only a few mesangial regions and therefore can easily be missed by routine histologic evaluation. More extensive involvement results in marked expansion of the mesangium, which can take on a nodular appearance and mimic mesangial sclerotic processes such as diabetic glomerulosclerosis. However, the often negative staining with PAS and JMS is more typical of amyloid." ; rdfs:label "Renal amyloidosis" ; rdfs:subClassOf obo:HP_0011034, obo:HP_0012210 . obo:HP_0001919 obo:IAO_0000115 "Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia)." ; oboInOwl:hasDbXref "MSH:D058186", "SNOMEDCT_US:14350001000004108", "SNOMEDCT_US:14669001", "UMLS:C0022660", "UMLS:C2609414" ; oboInOwl:hasExactSynonym "Acute kidney failure", "Acute renal failure" ; oboInOwl:id "HP:0001919" ; a owl:Class ; rdfs:comment "Acute renal failure is usually classified into prerenal (response to severe volume depletion), intrinsic (response to acute cytotoxic, ischemic, or inflammatory insults) and postrenal (response to obstruction of the passage of urine) etiologies." ; rdfs:label "Acute kidney injury" ; rdfs:subClassOf obo:HP_0000083 . obo:HP_0001920 obo:IAO_0000115 "The presence of stenosis of the renal artery." ; oboInOwl:hasDbXref "Fyler:2634", "MSH:D012078", "SNOMEDCT_US:282664001", "SNOMEDCT_US:302233006", "UMLS:C0035067" ; oboInOwl:hasExactSynonym "Narrowing of kidney artery" ; oboInOwl:id "HP:0001920" ; a owl:Class ; rdfs:label "Renal artery stenosis" ; rdfs:subClassOf obo:HP_0008776, obo:HP_0100545 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001184 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001922 obo:IAO_0000115 "The presence of clear, sharply defined vacuoles in the lymphocyte cytoplasm." ; oboInOwl:hasAlternativeId "HP:0008147", "HP:0008329" ; oboInOwl:hasDbXref "UMLS:C1836855" ; oboInOwl:hasExactSynonym "Enlarged lysosomal vacuoles in lymphocytes", "Vacuolated blood lymphocytes" ; oboInOwl:id "HP:0001922" ; a owl:Class ; rdfs:comment "Vacuolated lymphocytes occur most commonly as the peripheral blood manifestation of inherited metabolic disorders, including Niemann-Pick disease Type A, infantile sialic acid storage disorder, Wolman's disease, Mucolipidoses II and III, Salla disease, mannosidosis, Batten disease, GM1 gangliosidosis, neuraminidase deficiency, galactosidosis, fucosidosis, Pompe's disease, aspartylglycosaminuria and rarely, multiple sulfatase deficiency. The metabolic product, which causes vacuolation, depends on the specific enzyme deficiency." ; rdfs:label "Vacuolated lymphocytes" ; rdfs:subClassOf obo:HP_0004332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000941 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000542 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001923 obo:IAO_0000115 "An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation." ; oboInOwl:hasDbXref "MSH:D045262", "SNOMEDCT_US:46049004", "UMLS:C0206160" ; oboInOwl:hasExactSynonym "Increased immature red blood cells", "Increased number of immature red blood cells", "Increased reticulocyte count", "Increased reticulocytes" ; oboInOwl:id "HP:0001923" ; a owl:Class ; rdfs:label "Reticulocytosis" ; rdfs:subClassOf obo:HP_0004312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000558 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001924 obo:IAO_0000115 "Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining)." ; oboInOwl:hasAlternativeId "HP:0100791" ; oboInOwl:hasDbXref "MSH:D000756", "SNOMEDCT_US:41841004", "UMLS:C0002896" ; oboInOwl:hasExactSynonym "Hypersideremic anaemia", "Hypersideremic anemia", "Sideroblastic anaemia" ; oboInOwl:id "HP:0001924" ; a owl:Class ; rdfs:comment "Sideroblastic anemia may be either congenital or acquired. In sideroblastic anemia, the hematocrit tends to be around 20 to 30 percent, and the mean corpuscular volume is normal or low." ; rdfs:label "Sideroblastic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001927 obo:IAO_0000115 "Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars." ; oboInOwl:hasAlternativeId "HP:0005552" ; oboInOwl:hasDbXref "SNOMEDCT_US:250249008", "UMLS:C0687751" ; oboInOwl:hasExactSynonym "Acanthocytes", "Red cell acanthocytosis" ; oboInOwl:id "HP:0001927" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Acanthocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0001928 obo:IAO_0000115 "An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot." ; oboInOwl:hasDbXref "MSH:D001778", "MSH:D006474", "SNOMEDCT_US:362970003", "SNOMEDCT_US:64779008", "UMLS:C0005779", "UMLS:C0019087", "UMLS:C1846821" ; oboInOwl:hasExactSynonym "Abnormal blood coagulation studies", "Coagulation abnormalities", "Coagulation abnormality", "Haemorrhagic disorders" ; oboInOwl:hasRelatedSynonym "Blood coagulation disorder" ; oboInOwl:id "HP:0001928" ; a owl:Class ; rdfs:label "Abnormality of coagulation" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0050817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001929 obo:IAO_0000115 "Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX." ; oboInOwl:hasDbXref "MSH:D005173", "SNOMEDCT_US:49762007", "UMLS:C0015523" ; oboInOwl:hasExactSynonym "Low factor XI activity" ; oboInOwl:hasRelatedSynonym "Factor XI deficiency" ; oboInOwl:id "HP:0001929" ; a owl:Class ; rdfs:label "Reduced factor XI activity" ; rdfs:subClassOf obo:HP_0010989 . obo:HP_0001930 oboInOwl:hasDbXref "UMLS:C4025735" ; oboInOwl:hasExactSynonym "Nonspherocytic hemolytic anaemia" ; oboInOwl:id "HP:0001930" ; a owl:Class ; rdfs:label "Nonspherocytic hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0001931 obo:IAO_0000115 "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes." ; oboInOwl:hasDbXref "MSH:D000747", "SNOMEDCT_US:44452003", "UMLS:C0002884" ; oboInOwl:hasExactSynonym "Hypochromic anaemia" ; oboInOwl:id "HP:0001931" ; a owl:Class ; rdfs:comment "The low concentration of hemoglobin in the erythrocytes causes them to be abnormally pale, i.e., to have less color (be hypochromic)." ; rdfs:label "Hypochromic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001933 obo:IAO_0000115 "This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses)." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T07:14:00Z" ; oboInOwl:hasDbXref "UMLS:C0854107" ; oboInOwl:hasExactSynonym "Bleeding below the skin", "Subcutaneous haemorrhage" ; oboInOwl:id "HP:0001933" ; a owl:Class ; rdfs:comment "Purpura measure 0.3-1 cm (3-10 mm), whereas petechiae measure less than 3 mm, and ecchymoses greater than 1 cm." ; rdfs:label "Subcutaneous hemorrhage" ; rdfs:subClassOf obo:HP_0001892, obo:HP_0011276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011818 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001934 oboInOwl:hasAlternativeId "HP:0007463" ; oboInOwl:hasDbXref "UMLS:C1844374" ; oboInOwl:hasExactSynonym "Excessive bleeding after minor trauma", "Frequent bleeding with trauma", "Prolonged bleeding after minor trauma" ; oboInOwl:id "HP:0001934" ; a owl:Class ; rdfs:label "Persistent bleeding after trauma" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0001935 obo:IAO_0000115 "A kind of anemia in which the volume of the red blood cells is reduced." ; oboInOwl:hasDbXref "MSH:C562385", "SNOMEDCT_US:234349007", "UMLS:C0085576" ; oboInOwl:hasExactSynonym "Microcytic anaemia" ; oboInOwl:id "HP:0001935" ; a owl:Class ; rdfs:comment "In normocytic anemia, the mean corpuscular volume (MCV) is below normal limits (>80 fl in adults)." ; rdfs:label "Microcytic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001937 oboInOwl:hasDbXref "MSH:D000743", "SNOMEDCT_US:51071000", "UMLS:C0221021" ; oboInOwl:hasExactSynonym "Microangiopathic hemolytic anaemia" ; oboInOwl:id "HP:0001937" ; a owl:Class ; rdfs:label "Microangiopathic hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0001939 oboInOwl:hasAlternativeId "HP:0002146", "HP:0004355", "HP:0004367" ; oboInOwl:hasDbXref "UMLS:C4021768" ; oboInOwl:hasExactSynonym "Laboratory abnormality", "Metabolism abnormality" ; oboInOwl:id "HP:0001939" ; a owl:Class ; rdfs:label "Abnormality of metabolism/homeostasis" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0008152 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001941 obo:IAO_0000115 "Abnormal acid accumulation or depletion of base." ; oboInOwl:hasAlternativeId "HP:0001940" ; oboInOwl:hasDbXref "MSH:D000138", "SNOMEDCT_US:51387008", "UMLS:C0001122" ; oboInOwl:id "HP:0001941" ; a owl:Class ; rdfs:comment "When describing acid-base abnormalities, acidosis and alkalosis refer to physiological processes that lower or raise the pH, respectively, while acidemia and alkalemia simply describe the state of an abnormal blood pH. This distinction is important: a patient with acidemia could have both a respiratory and metabolic acidosis as well as a concurrent metabolic alkalosis." ; rdfs:label "Acidosis" ; rdfs:subClassOf obo:HP_0004360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_37527 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001942 obo:IAO_0000115 "Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause." ; oboInOwl:hasAlternativeId "HP:0004895", "HP:0004907" ; oboInOwl:hasDbXref "MSH:D000138", "SNOMEDCT_US:59455009", "UMLS:C0220981" ; oboInOwl:id "HP:0001942" ; a owl:Class ; rdfs:comment "The Henderson-Hasselbalch method defines metabolic acidosis by the presence of an acid-base imbalance associated with a plasma bicarbonate concentration below 20 mmol/L. The association of this imbalance with decreased pH is called acidemia, which is often described as severe when the pH is equal to or below 7.20. Arterial blood gas measurements can be performed in patients with a decreased plasma bicarbonate level so as to eliminate respiratory alkalosis, confirm the diagnosis of metabolic acidosis, and test for mixed acidosis." ; rdfs:label "Metabolic acidosis" ; rdfs:subClassOf obo:HP_0001941 . obo:HP_0001943 obo:IAO_0000115 "A decreased concentration of glucose in the blood." ; oboInOwl:hasAlternativeId "HP:0003356" ; oboInOwl:hasDbXref "MSH:D007003", "SNOMEDCT_US:237630007", "SNOMEDCT_US:271327008", "SNOMEDCT_US:302866003", "UMLS:C0020615" ; oboInOwl:hasExactSynonym "Hypoglycaemia", "Low blood sugar" ; oboInOwl:id "HP:0001943" ; a owl:Class ; rdfs:label "Hypoglycemia" ; rdfs:subClassOf obo:HP_0011015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_17234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001944 oboInOwl:hasDbXref "MSH:D003681", "SNOMEDCT_US:34095006", "UMLS:C0011175" ; oboInOwl:hasExactSynonym "Dehydration", "Exsiccosis" ; oboInOwl:id "HP:0001944" ; a owl:Class ; rdfs:label "Dehydration" ; rdfs:subClassOf obo:HP_0011032 . obo:HP_0001945 obo:IAO_0000115 "Body temperature elevated above the normal range." ; oboInOwl:hasDbXref "MSH:D005334", "SNOMEDCT_US:386661006", "SNOMEDCT_US:50177009", "UMLS:C0015967" ; oboInOwl:hasExactSynonym "Fever", "Hyperthermia", "Pyrexia" ; oboInOwl:id "HP:0001945" ; a owl:Class ; rdfs:comment "Fever has been defined as a state of elevated core temperature, which is often, but not necessarily, part of the defensive responses of multicellular organisms (host) to the invasion of live (microorganisms) or inanimate matter recognized as pathogenic or alien by the host. The febrile response (of which fever is a component) is a complex physiologic reaction to disease, involving a cytokine-mediated rise in core temperature, generation of acute phase reactants, and activation of numerous physiologic, endocrinologic, and immunologic systems. The rise in temperature during fever is to be distinguished from that occurring during episodes of hyperthermia. Unlike fever, hyperthermia involves an unregulated rise in body temperature in which pyrogenic cytokines are not directly involved and against which standard antipyretics are ineffective. It represents a failure of thermoregulatory homeostasis, in which there is uncontrolled heat production, inadequate heat dissipation, or defective hypothalamic thermoregulation." ; rdfs:label "Fever" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0001946 obo:IAO_0000115 "Presence of elevated levels of ketone bodies in the body." ; oboInOwl:hasAlternativeId "HP:0003543" ; oboInOwl:hasDbXref "MSH:D007662", "SNOMEDCT_US:213281004", "SNOMEDCT_US:2538008", "UMLS:C0022638", "UMLS:C0235430" ; oboInOwl:hasExactSynonym "High levels of ketone bodies", "Hyperketosis" ; oboInOwl:id "HP:0001946" ; a owl:Class ; rdfs:comment "Ketone bodies are formed from acetyl-CoA in the liver by ketogenesis when the liver glycogen stores are depleted. Ketone bodies are acidic, and ketoacidosis ensues if the compensatory mechanisms are overloaded. The predominant ketones being acetoacetate, acetone, and beta-hydroxybutyrate." ; rdfs:label "Ketosis" ; rdfs:subClassOf obo:HP_0001939 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046951 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001947 obo:IAO_0000115 "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis." ; oboInOwl:hasDbXref "MSH:D000141", "SNOMEDCT_US:1776003", "UMLS:C0001126" ; oboInOwl:hasExactSynonym "Accumulation of acid in body due to kidney problem" ; oboInOwl:id "HP:0001947" ; a owl:Class ; rdfs:label "Renal tubular acidosis" ; rdfs:subClassOf obo:HP_0000124, obo:HP_0001942 . obo:HP_0001948 obo:IAO_0000115 "Depletion of acid or accumulation base in the body fluids." ; oboInOwl:hasDbXref "MSH:D000471", "SNOMEDCT_US:21420006", "UMLS:C0002063" ; oboInOwl:id "HP:0001948" ; a owl:Class ; rdfs:comment "When describing acid-base abnormalities, acidosis and alkalosis refer to physiological processes that lower or raise the pH, respectively, while acidemia and alkalemia simply describe the state of an abnormal blood pH. This distinction is important: a patient with acidemia could have both a respiratory and metabolic acidosis as well as a concurrent metabolic alkalosis." ; rdfs:label "Alkalosis" ; rdfs:subClassOf obo:HP_0004360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22695 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001949 oboInOwl:hasDbXref "SNOMEDCT_US:22774003", "UMLS:C0085570" ; oboInOwl:id "HP:0001949" ; a owl:Class ; rdfs:label "Hypokalemic alkalosis" ; rdfs:subClassOf obo:HP_0001948 . obo:HP_0001950 obo:IAO_0000115 "Alkalosis due to excess loss of carbon dioxide from the body." ; oboInOwl:hasDbXref "MSH:D000472", "SNOMEDCT_US:111378004", "UMLS:C0002064" ; oboInOwl:id "HP:0001950" ; a owl:Class ; rdfs:label "Respiratory alkalosis" ; rdfs:subClassOf obo:HP_0001948 . obo:HP_0001951 oboInOwl:hasDbXref "UMLS:C1839541" ; oboInOwl:id "HP:0001951" ; a owl:Class ; rdfs:label "Episodic ammonia intoxication" ; rdfs:subClassOf obo:HP_0004364 . obo:HP_0001952 obo:IAO_0000115 "Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM)." ; oboInOwl:hasAlternativeId "HP:0000833" ; oboInOwl:hasBroadSynonym "Abnormal glucose tolerance" ; oboInOwl:hasDbXref "UMLS:C0235401" ; oboInOwl:hasExactSynonym "Glucose intolerance" ; oboInOwl:id "HP:0001952" ; a owl:Class ; rdfs:label "Glucose intolerance" ; rdfs:subClassOf obo:HP_0011014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001650 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0046323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001953 obo:IAO_0000115 "A type of diabetic metabolic abnormality with an accumulation of ketone bodies." ; oboInOwl:hasAlternativeId "HP:0008253" ; oboInOwl:hasDbXref "MSH:D016883", "SNOMEDCT_US:420422005", "UMLS:C0011880" ; oboInOwl:hasExactSynonym "Diabetic ketosis" ; oboInOwl:id "HP:0001953" ; a owl:Class ; rdfs:label "Diabetic ketoacidosis" ; rdfs:subClassOf obo:HP_0000819, obo:HP_0001993 . obo:HP_0001954 obo:IAO_0000115 "Periodic (episodic or recurrent) bouts of fever." ; oboInOwl:hasAlternativeId "HP:0004903", "HP:0005962", "HP:0005966", "HP:0005980" ; oboInOwl:hasDbXref "SNOMEDCT_US:77957000", "UMLS:C0277799" ; oboInOwl:hasExactSynonym "Episodic fever", "Hyperthermia, episodic", "Increased body temperature, episodic", "Intermittent fever" ; oboInOwl:id "HP:0001954" ; a owl:Class ; rdfs:label "Recurrent fever" ; rdfs:subClassOf obo:HP_0001945 . obo:HP_0001955 obo:IAO_0000115 "Episodes of fever for which no infectious cause can be identified." ; oboInOwl:hasDbXref "UMLS:C1844662" ; oboInOwl:hasExactSynonym "Unexplained fevers" ; oboInOwl:id "HP:0001955" ; a owl:Class ; rdfs:label "Unexplained fevers" ; rdfs:subClassOf obo:HP_0001945 . obo:HP_0001956 obo:IAO_0000115 "Obesity located preferentially in the trunk of the body as opposed to the extremities." ; oboInOwl:hasAlternativeId "HP:0008885" ; oboInOwl:hasDbXref "MSH:D056128", "SNOMEDCT_US:248311001", "UMLS:C0311277" ; oboInOwl:hasExactSynonym "Centripetal obesity", "Truncal obesity" ; oboInOwl:id "HP:0001956" ; a owl:Class ; rdfs:label "Truncal obesity" ; rdfs:subClassOf obo:HP_0001513 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001958 oboInOwl:hasDbXref "UMLS:C1865292" ; oboInOwl:id "HP:0001958" ; a owl:Class ; rdfs:label "Nonketotic hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0001959 obo:IAO_0000115 "Excessive thirst manifested by excessive fluid intake." ; oboInOwl:hasDbXref "MSH:D059606", "SNOMEDCT_US:17173007", "SNOMEDCT_US:267026004", "UMLS:C0085602" ; oboInOwl:hasExactSynonym "Extreme thirst" ; oboInOwl:id "HP:0001959" ; a owl:Class ; rdfs:label "Polydipsia" ; rdfs:subClassOf obo:HP_0030082 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000542 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001960 oboInOwl:hasDbXref "UMLS:C0740898" ; oboInOwl:id "HP:0001960" ; a owl:Class ; rdfs:label "Hypokalemic metabolic alkalosis" ; rdfs:subClassOf obo:HP_0001949, obo:HP_0200114 . obo:HP_0001961 oboInOwl:hasDbXref "UMLS:C3151525" ; oboInOwl:hasExactSynonym "Small heart", "Underdeveloped heart" ; oboInOwl:id "HP:0001961" ; a owl:Class ; rdfs:label "Hypoplastic heart" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001962 obo:IAO_0000115 "A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia." ; oboInOwl:hasAlternativeId "HP:0001676" ; oboInOwl:hasDbXref "SNOMEDCT_US:80313002", "UMLS:C0030252" ; oboInOwl:hasExactSynonym "Heart palpitations", "Missed heart beat", "Palpitations", "Skipped heart beat" ; oboInOwl:id "HP:0001962" ; a owl:Class ; rdfs:label "Palpitations" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0001963 obo:IAO_0000115 "A type of hearing impairment prominently characterized by a difficulty in understanding speech, rather than an inability to hear speech. Poor speech discrimination is a very common symptom of high frequency hearing loss." ; oboInOwl:hasDbXref "UMLS:C1836752" ; oboInOwl:hasExactSynonym "Abnormal speech discrimination", "Poor speech discrimination" ; oboInOwl:id "HP:0001963" ; a owl:Class ; rdfs:label "Abnormal speech discrimination" ; rdfs:subClassOf obo:HP_0000364 . obo:HP_0001964 obo:IAO_0000115 "Absence or underdevelopment of the metatarsal bones." ; oboInOwl:hasDbXref "UMLS:C1860182" ; oboInOwl:hasExactSynonym "Absent or hypoplastic metatarsal", "Absent/hypoplastic metacarpals", "Absent/hypoplastic metatarsals", "Absent/small long bone of foot", "Absent/underdeveloped long bone of foot", "Aplastic/hypoplastic metatarsals" ; oboInOwl:id "HP:0001964" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of metatarsal bones" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0006494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001965 obo:IAO_0000115 "Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows." ; oboInOwl:hasDbXref "UMLS:C4025734" ; oboInOwl:hasExactSynonym "Abnormality of the scalp", "Anomaly of scalp" ; oboInOwl:id "HP:0001965" ; a owl:Class ; rdfs:comment "The scalp of the head has the following five layers: 1) skin and head hair; 2) connective tissue; 3) the aponeurosis (a layer of dense fibrous tissue); 4) loose areolar connective tissue; and 5) the periosteum of the skull bones." ; rdfs:label "Abnormal scalp morphology" ; rdfs:subClassOf obo:HP_0000234 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001966 obo:IAO_0000115 "An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries." ; oboInOwl:hasDbXref "UMLS:C4025733" ; oboInOwl:hasExactSynonym "Abnormality glomerular mesangium morphology", "Abnormality of the glomerular mesangium", "Mesangial abnormality" ; oboInOwl:id "HP:0001966" ; a owl:Class ; rdfs:comment "Mesangial cells constitute the central stalk of the glomerulus and are in continuity with the extraglomerular mesangium and the juxtaglomerular apparatus. They have contractile properties generated by anchoring filaments to glomerular basement membrane opposite podocyte foot processes and at the paramesangial angles, thereby assisting in the maintenance of capillary organization and convolution. On the capillary lumen side, mesangial cells are in direct contact with endothelial cells without an intervening basement membrane." ; rdfs:label "Abnormal glomerular mesangium morphology" ; rdfs:subClassOf obo:HP_0000095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001967 obo:IAO_0000115 "Diffuse sclerosis of the mesangium, as manifestated by diffuse mesangial matrix expansion." ; oboInOwl:hasAlternativeId "HP:0004728" ; oboInOwl:hasDbXref "MSH:C537346", "SNOMEDCT_US:111406002", "UMLS:C0268747" ; oboInOwl:hasExactSynonym "Diffuse mesangial sclerosis glomerulopathy", "Mesangial sclerosis" ; oboInOwl:id "HP:0001967" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by renal biopsy." ; rdfs:label "Diffuse mesangial sclerosis" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0001969 obo:IAO_0000115 "An abnormality that involves the tubules and interstitial tissue of the kidney." ; oboInOwl:hasAlternativeId "HP:0008654" ; oboInOwl:hasDbXref "MSH:D009395", "SNOMEDCT_US:28689008", "SNOMEDCT_US:428255004", "UMLS:C0041349", "UMLS:C4025732" ; oboInOwl:hasExactSynonym "Tubulointerstitial abnormality" ; oboInOwl:hasRelatedSynonym "Tubulointerstitial nephropathy" ; oboInOwl:id "HP:0001969" ; a owl:Class ; rdfs:label "Abnormal tubulointerstitial morphology" ; rdfs:subClassOf obo:HP_0000091, obo:HP_0032581 . obo:HP_0001970 obo:IAO_0000115 "A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." ; oboInOwl:hasDbXref "MSH:D009395", "SNOMEDCT_US:28689008", "SNOMEDCT_US:428255004", "UMLS:C0041349" ; oboInOwl:hasExactSynonym "Interstitial nephritis", "Nephritis, Tubulointerstitial" ; oboInOwl:id "HP:0001970" ; a owl:Class ; rdfs:label "Tubulointerstitial nephritis" ; rdfs:subClassOf obo:HP_0001969 . obo:HP_0001971 obo:IAO_0000115 "A malfunctioning of the spleen in which it prematurely destroys red blood cells." ; oboInOwl:hasDbXref "MSH:D006971", "SNOMEDCT_US:58381000", "UMLS:C0020532" ; oboInOwl:id "HP:0001971" ; a owl:Class ; rdfs:comment "The spleen normally functions to remove senescent red blood cells (RBCs) from the circulation. Hypersplenism represents a pathological acceleration of this function, resulting in the premature removal from the circulation of RBCs and other cellular components of the blood, often accompanied by an increase in size of the spleen (splenomegaly)." ; rdfs:label "Hypersplenism" ; rdfs:subClassOf obo:HP_0025409 . obo:HP_0001972 obo:IAO_0000115 "A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH)." ; oboInOwl:hasDbXref "MSH:D000748", "SNOMEDCT_US:83414005", "UMLS:C0002886" ; oboInOwl:hasExactSynonym "Macrocytic anaemia" ; oboInOwl:id "HP:0001972" ; a owl:Class ; rdfs:comment "The causes of macrocytosis can be broadly classified as megaloblastic and nonmegaloblastic. Megaloblastic processes are characterized on the peripheral smear by macroovalocytes and hypersegmented neutrophils, which are absent in nonmegaloblastic macrocytic processes. Nonmegaloblastic processes have round macrocytes or macroreticulocytes." ; rdfs:label "Macrocytic anemia" ; rdfs:subClassOf obo:HP_0010972 . obo:HP_0001973 obo:IAO_0000115 "The presence of thrombocytopenia in combination with detection of antiplatelet antibodies." ; oboInOwl:hasAlternativeId "HP:0001936", "HP:0004806", "HP:0004829" ; oboInOwl:hasDbXref "MSH:D016553", "SNOMEDCT_US:128091003", "SNOMEDCT_US:13172003", "SNOMEDCT_US:234490009", "SNOMEDCT_US:32273002", "UMLS:C0242584", "UMLS:C0398650", "UMLS:C0920163" ; oboInOwl:hasExactSynonym "Idiopathic thrombocytopenia", "Immune thrombocytopenia" ; oboInOwl:hasRelatedSynonym "Idiopathic thrombocytopenic purpura" ; oboInOwl:id "HP:0001973" ; a owl:Class ; rdfs:comment """Autoimmune thrombocytopenia is causes by accelerated destruction of auto-antibody sensitized platelets in the reticular-endothelial system. Common etiologies include idiopathic thrombocytopenic purpura (ITP), Drug-induced autoimmune thrombocytopenia, and autoimmune thrombocytopenia following viral infection.""" ; rdfs:label "Autoimmune thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873, obo:HP_0002960 . obo:HP_0001974 obo:IAO_0000115 "An abnormal increase in the number of leukocytes in the blood." ; oboInOwl:hasDbXref "MSH:D007964", "SNOMEDCT_US:111583006", "UMLS:C0023518" ; oboInOwl:hasExactSynonym "Elevated white blood count", "High white blood count", "Increased blood leukocyte number" ; oboInOwl:id "HP:0001974" ; a owl:Class ; rdfs:label "Leukocytosis" ; rdfs:subClassOf obo:HP_0011893 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000738 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001975 obo:IAO_0000115 "Decreased cell membrane concentration of glycoprotein IIb-IIIa." ; oboInOwl:hasDbXref "MSH:D013915", "SNOMEDCT_US:32942005", "UMLS:C0040015", "UMLS:C4021767" ; oboInOwl:hasExactSynonym "Reduced level of platelet glycoprotein IIb/IIIa complex" ; oboInOwl:hasRelatedSynonym "Glanzmann thrombasthenia" ; oboInOwl:id "HP:0001975" ; a owl:Class ; rdfs:comment "The glycoprotein IIb-IIIa is an integrin complex found on platelets that acts a receptor for fibrinogen and aids in platelet activation." ; rdfs:label "Decreased platelet glycoprotein IIb-IIIa" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0001976 obo:IAO_0000115 "An abnormality of coagulation related to a decreased concentration of antithrombin-III." ; oboInOwl:hasDbXref "MSH:D020152", "SNOMEDCT_US:36351005", "UMLS:C0272375" ; oboInOwl:hasExactSynonym "Anti-thrombin III deficiency", "Antithrombin III deficiency", "Decreased antithrombin III" ; oboInOwl:id "HP:0001976" ; a owl:Class ; rdfs:comment "Antithrombin III (ATIII) inhibits the coagulation cascade by lysing thrombin and factor Xa. The defective inhibition of the coagulation cascade is associated with an increased risk of venous and arterial thrombosis. The physiological target proteases of antithrombin are those of the intrinsic pathway, namely the activated forms of Factor X, Factor IX, Factor XI, Factor XII, and, to a greater extent, Factor II (thrombin), and also the activated form of Factor VII (VIIa) from the the extrinsic pathway." ; rdfs:label "Reduced antithrombin III activity" ; rdfs:subClassOf obo:HP_0010988, obo:HP_0010989 . obo:HP_0001977 obo:IAO_0000115 "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis)." ; oboInOwl:hasDbXref "UMLS:C4025731" ; oboInOwl:hasExactSynonym "Abnormal blood clot", "Abnormal blood clotting" ; oboInOwl:id "HP:0001977" ; a owl:Class ; rdfs:label "Abnormal thrombosis" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0001978 obo:IAO_0000115 "The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms." ; oboInOwl:hasAlternativeId "HP:0004847" ; oboInOwl:hasDbXref "SNOMEDCT_US:124958002", "SNOMEDCT_US:42952007", "UMLS:C1292120", "UMLS:C2613439" ; oboInOwl:hasRelatedSynonym "Extramedullary erythropoiesis" ; oboInOwl:id "HP:0001978" ; a owl:Class ; rdfs:comment "During fetal life, the formation of cellular blood components occurs mainly in the liver, shifting to the bone marrow postnatally. SOme pathological conditions associated with a severe reduction of marrow hematopoiesis are associated with extramedullary hematopoiesis." ; rdfs:label "Extramedullary hematopoiesis" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001980 obo:IAO_0000115 "Abnormal increased number of megaloblasts in the bone marrow." ; oboInOwl:hasDbXref "SNOMEDCT_US:167921008", "UMLS:C0238801" ; oboInOwl:id "HP:0001980" ; a owl:Class ; rdfs:comment "A megaloblast is an abnormally large nucleated red blood cell found especially in people with pernicious anemia. Megaloblasts, like their normal counterparts, normoblasts, are immature red cell precursors in the bone marrow. Megaloblasts display both a larger size than normoblasts as well as a fine reticular nuclear structure." ; rdfs:label "Megaloblastic bone marrow" ; rdfs:subClassOf obo:HP_0012145 . obo:HP_0001981 obo:IAO_0000115 "The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:385472000", "UMLS:C0344386" ; oboInOwl:hasExactSynonym "Schistocytes" ; oboInOwl:id "HP:0001981" ; a owl:Class ; rdfs:label "Schistocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0001982 obo:IAO_0000115 "An abnormality of histiocytes, in which the cells take on a sea blue appearance due to abnormally increased lipid content. Histiocytes are a type of macrophage. Sea-blue histiocytes are typically large macrophages from 20 to 60 micrometers in diameter with a single eccentric nucleus whose cytoplasm if packed with sea-blue or blue-green granules when stained with Wright-Giemsa." ; oboInOwl:hasDbXref "MSH:D012618", "SNOMEDCT_US:37821003", "UMLS:C0036489" ; oboInOwl:hasExactSynonym "Sea-blue histiocyte" ; oboInOwl:id "HP:0001982" ; a owl:Class ; rdfs:label "Sea-blue histiocytosis" ; rdfs:subClassOf obo:HP_0004311 . obo:HP_0001983 obo:IAO_0000115 "A reduction in the expression of CD43 on the cell surface of lymphocytes." ; oboInOwl:hasDbXref "UMLS:C4021766" ; oboInOwl:hasExactSynonym "Cd43 defectively expressed on surface of blood cells", "Reduced lymphocyte surface expression of sialophorin" ; oboInOwl:id "HP:0001983" ; a owl:Class ; rdfs:comment "CD43 is a cell-surface sialoglycoprotein that is expressed, typically at high levels, on all leukocytes except most resting B lymphocytes." ; rdfs:label "Reduced lymphocyte surface expression of CD43" ; rdfs:subClassOf obo:HP_0031383 . obo:HP_0001984 oboInOwl:hasDbXref "UMLS:C1396243" ; oboInOwl:id "HP:0001984" ; a owl:Class ; rdfs:label "Intolerance to protein" ; rdfs:subClassOf obo:HP_0012537 . obo:HP_0001985 obo:IAO_0000115 "A decreased concentration of glucose in the blood associated with a reduced concentration of ketone bodies." ; oboInOwl:hasAlternativeId "HP:0005969" ; oboInOwl:hasDbXref "UMLS:C1856438" ; oboInOwl:hasExactSynonym "Hypoglycemia, hypoketotic" ; oboInOwl:id "HP:0001985" ; a owl:Class ; rdfs:comment "Normally, decreased glucose production leads to increased mitochondrial fatty acid beta-oxidation and the production of ketones. Thus, ketones provide an indication of whether the hypoglycemia is a result of inadequate production or overutilization of glucose (which tends to be associated with low plasma ketone levels). Hypoketotic hypoglycemia developing within several minutes of feeding is typical of hyperinsulinism. A good starting point for evaluating hypoglycemia is to divide patients into ketotic or non-ketotic. Normal physiologic response to decreased glucose production is increased mitochondrial fatty acid beta-oxidation and the production of ketones. Ketones provide an indirect indication of whether hypoglycemia is the result of inadequate production or of over-utilization of glucose (insulin-induced over-utilization, associated with low urine or plasma ketones). The history of the relationship of the hypoglycemia to feeding is often helpful. Hypoketotic hypoglycemia developing within several minutes of feeding is typical of hyperinsulinism. Patients with defects in glycogen breakdown, gluconeogenesis, or fatty acid oxidation tend to tolerate short-term fasting much better." ; rdfs:label "Hypoketotic hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0001986 oboInOwl:hasDbXref "UMLS:C1112601" ; oboInOwl:hasExactSynonym "Hyperosmolar dehydration" ; oboInOwl:id "HP:0001986" ; a owl:Class ; rdfs:label "Hypertonic dehydration" ; rdfs:subClassOf obo:HP_0001944 . obo:HP_0001987 obo:IAO_0000115 "An increased concentration of ammonia in the blood." ; oboInOwl:hasAlternativeId "HP:0008308", "HP:0008334" ; oboInOwl:hasDbXref "MSH:D022124", "SNOMEDCT_US:9360008", "UMLS:C0220994" ; oboInOwl:hasExactSynonym "High blood ammonia levels" ; oboInOwl:id "HP:0001987" ; a owl:Class ; rdfs:label "Hyperammonemia" ; rdfs:subClassOf obo:HP_0002157 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001988 obo:IAO_0000115 "Recurrent episodes of decreased concentration of glucose in the blood." ; oboInOwl:hasDbXref "UMLS:C1846288" ; oboInOwl:hasExactSynonym "Hypoglycemic episodes", "Recurrent hypoglycaemia", "Recurrent hypoglycemic episodes", "Recurrent low blood sugar levels", "hypoglycaemia, recurrent", "hypoglycemia, recurrent" ; oboInOwl:id "HP:0001988" ; a owl:Class ; rdfs:label "Recurrent hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_17234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0001989 obo:IAO_0000115 "Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia)." ; oboInOwl:hasDbXref "MSH:C536647", "SNOMEDCT_US:401138005", "UMLS:C1276035", "UMLS:C3151520" ; oboInOwl:hasExactSynonym "Foetal akinesia sequence" ; oboInOwl:hasRelatedSynonym "Early severe fetal akinesia sequence", "Early severe foetal akinesia sequence", "Fetal akinesia", "Foetal akinesia" ; oboInOwl:id "HP:0001989" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fetal akinesia sequence" ; rdfs:subClassOf obo:HP_0001558 . obo:HP_0001991 obo:IAO_0000115 "Absence or hypoplasia of toes." ; oboInOwl:hasDbXref "UMLS:C3551148" ; oboInOwl:hasExactSynonym "Absent/small toe", "Absent/underdeveloped toe", "Aplastic/hypoplastic toe phalanges" ; oboInOwl:hasRelatedSynonym "Absent/hypoplastic toes" ; oboInOwl:id "HP:0001991" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of toe" ; rdfs:subClassOf obo:HP_0001780, obo:HP_0006494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001992 obo:IAO_0000115 "Excretion of non-amino organic acids in urine." ; oboInOwl:hasDbXref "UMLS:C0241775" ; oboInOwl:id "HP:0001992" ; a owl:Class ; rdfs:label "Organic aciduria" ; rdfs:subClassOf obo:HP_0012072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_64709 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001993 obo:IAO_0000115 "Acidosis resulting from accumulation of ketone bodies." ; oboInOwl:hasDbXref "SNOMEDCT_US:56051008", "UMLS:C0220982" ; oboInOwl:id "HP:0001993" ; a owl:Class ; rdfs:comment "Ketoacidosis can result from diabetes, alcoholic ketoacidosis, prolonged fasting, as well as several hereditary diseases of metabolism." ; rdfs:label "Ketoacidosis" ; rdfs:subClassOf obo:HP_0001941, obo:HP_0001946 . obo:HP_0001994 obo:IAO_0000115 "An inability of the tubules in the kidney to reabsorb small molecules, causing increased urinary loss of electrolytes (sodium, potassium, bicarbonate), minerals, glucose, amino acids, and water." ; oboInOwl:hasDbXref "MSH:D005198", "SNOMEDCT_US:236468006", "SNOMEDCT_US:44673006", "UMLS:C0341703" ; oboInOwl:hasExactSynonym "De toni-fanconi-debre syndrome", "Renal tubular fanconi syndrome" ; oboInOwl:id "HP:0001994" ; a owl:Class ; rdfs:label "Renal Fanconi syndrome" ; rdfs:subClassOf obo:HP_0001947, obo:HP_0011038 . obo:HP_0001995 obo:IAO_0000115 "Acidosis (pH less than 7.35) that develops with an increase in ionic chloride." ; oboInOwl:hasDbXref "SNOMEDCT_US:18104000", "UMLS:C0085569" ; oboInOwl:id "HP:0001995" ; a owl:Class ; rdfs:label "Hyperchloremic acidosis" ; rdfs:subClassOf obo:HP_0001941 . obo:HP_0001996 obo:IAO_0000115 "Longstanding metabolic acidosis." ; oboInOwl:hasDbXref "UMLS:C0740749" ; oboInOwl:id "HP:0001996" ; a owl:Class ; rdfs:comment "Severe chronic metabolic acidosis has two well-recognized major systemic consequences. First, metabolic acidosis, or acidemia, induces increased protein catabolism, decreased protein synthesis, and negative nitrogen and total body protein balance, which improve upon bicarbonate supplementation. Second, metabolic acidosis causes physicochemical dissolution of bone and cell-mediated bone resorption by inhibition of osteoblast and stimulation of osteoclast function." ; rdfs:label "Chronic metabolic acidosis" ; rdfs:subClassOf obo:HP_0001942, obo:HP_0012468 . obo:HP_0001997 obo:IAO_0000115 "Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues." ; oboInOwl:hasAlternativeId "HP:0001368" ; oboInOwl:hasDbXref "MSH:D006073", "MSH:D015210", "SNOMEDCT_US:170733007", "SNOMEDCT_US:190828008", "SNOMEDCT_US:48440001", "SNOMEDCT_US:90560007", "UMLS:C0003868", "UMLS:C0018099" ; oboInOwl:hasExactSynonym "Gouty arthritis" ; oboInOwl:id "HP:0001997" ; a owl:Class ; rdfs:label "Gout" ; rdfs:subClassOf obo:HP_0001369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_27226 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000982 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0001998 oboInOwl:hasDbXref "SNOMEDCT_US:52767006", "UMLS:C0158986" ; oboInOwl:hasExactSynonym "Low blood sugar in newborn" ; oboInOwl:id "HP:0001998" ; a owl:Class ; rdfs:label "Neonatal hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0001999 obo:IAO_0000115 "An abnormal morphology (form) of the face or its components." ; oboInOwl:hasAlternativeId "HP:0002004", "HP:0002260", "HP:0004643", "HP:0004649", "HP:0004652", "HP:0004655", "HP:0004675", "HP:0005124" ; oboInOwl:hasBroadSynonym "Deformity of face", "Malformation of face" ; oboInOwl:hasDbXref "SNOMEDCT_US:248200007", "SNOMEDCT_US:32003007", "SNOMEDCT_US:398206004", "SNOMEDCT_US:398302004", "UMLS:C0266617", "UMLS:C0424503", "UMLS:C1385263", "UMLS:C4072832", "UMLS:C4072833" ; oboInOwl:hasExactSynonym "Abnormal facial shape", "Abnormal morphology of the face", "Distinctive facies", "Dysmorphic facial features", "Dysmorphic facies", "Facial dysmorphism", "Unusual facial appearance", "Unusual facies" ; oboInOwl:hasRelatedSynonym "Distortion of face", "Funny looking face" ; oboInOwl:id "HP:0001999" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term now covers many of the historical inexact descriptions such as Bird-like facies that probably should be avoided in modern genetics. This portion of the Ontology should be revised." ; rdfs:label "Abnormal facial shape" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002000 obo:IAO_0000115 "Reduced distance from the anterior border of the naris to the subnasale." ; oboInOwl:hasDbXref "UMLS:C1857479", "UMLS:C4280585" ; oboInOwl:hasExactSynonym "Columella, short", "Decreased length of columella" ; oboInOwl:hasRelatedSynonym "Hypoplasia of columella" ; oboInOwl:id "HP:0002000" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is often accompanied by a Depressed nasal tip but this should be assessed and coded separately. The term Absent columella has been deleted because a columella is thought to always be present, except in Single naris and Proboscis." ; rdfs:label "Short columella" ; rdfs:subClassOf obo:HP_0009929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008341 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002002 obo:IAO_0000115 "Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal base and upper vermillion border." ; oboInOwl:hasAlternativeId "HP:0000305", "HP:0004654" ; oboInOwl:hasDbXref "UMLS:C1839797", "UMLS:C4020861" ; oboInOwl:hasExactSynonym "Increased depth of philtrum", "Philtrum, deep", "Prominent philtrum", "Pronounced philtrum" ; oboInOwl:hasRelatedSynonym "Depressed philtrum" ; oboInOwl:id "HP:0002002" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Some have used the term depressed philtrum, suggesting the presence of normal philtral ridges with a deeper groove, while admitting the difficulty in distinguishing this from prominent ridges with a normal philtral groove. We are unaware of a truly deepened philtral groove with normal height of the ridges." ; rdfs:label "Deep philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002003 oboInOwl:hasDbXref "UMLS:C1839783", "UMLS:C4280583", "UMLS:C4280584" ; oboInOwl:hasExactSynonym "Increased size of forehead", "Increased size of frontal region of face", "Large forehead" ; oboInOwl:hasNarrowSynonym "Hyperplasia of forehead", "Hypertrophy of forehead" ; oboInOwl:id "HP:0002003" ; a owl:Class ; rdfs:label "Large forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002006 obo:IAO_0000115 "A congenital malformation with a cleft (gap or opening) in the face." ; oboInOwl:hasDbXref "SNOMEDCT_US:92821006", "UMLS:C0685787" ; oboInOwl:hasExactSynonym "Cleft of the face", "Facial cleft", "Tessier facial cleft" ; oboInOwl:hasRelatedSynonym "Facial clefts" ; oboInOwl:id "HP:0002006" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The categories of facial cleft (subterms) correspond to Tessier, P (1976) Classification of rare craniofacial clefts, Journal of Maxillofacial Surgery; 4:69-92. There exists a competing classification system by Van der Meulen that divides different types of clefts based on where the development arrest occurs in the embryogenesis. The HPO uses the Tessier classification because it is based on phenotype rather than pathophysiological considerations." ; rdfs:label "Facial cleft" ; rdfs:subClassOf obo:HP_0000271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002007 obo:IAO_0000115 "Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline." ; oboInOwl:hasAlternativeId "HP:0000254", "HP:0000333", "HP:0001358", "HP:0001359" ; oboInOwl:hasDbXref "SNOMEDCT_US:90145001", "UMLS:C0221354" ; oboInOwl:hasExactSynonym "Frontal protruberance", "Skull bossing" ; oboInOwl:id "HP:0002007" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is not the same as prominent forehead." ; rdfs:label "Frontal bossing" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0011218 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002009 obo:IAO_0000115 "A facial appearance characteristic of a fetus or neonate due to oligohydramnios experienced in the womb, comprising ocular hypertelorism, low-set ears, receding chin, and flattening of the nose." ; oboInOwl:hasDbXref "SNOMEDCT_US:24814002", "UMLS:C0266619" ; oboInOwl:id "HP:0002009" ; a owl:Class ; rdfs:comment "Potter sequence is a sequence of events resulting from oligohydramnios due to any of a number of causes such as bilateral renal agenesis. Affected fetuses often have a characteristic facial appearance." ; rdfs:label "Potter facies" ; rdfs:subClassOf obo:HP_0011334 . obo:HP_0002010 oboInOwl:hasDbXref "UMLS:C1851835" ; oboInOwl:hasExactSynonym "Decreased breadth of upper jaw bones", "Decreased transverse dimension of maxilla", "Decreased width of maxilla", "Decreased width of upper jaw bones", "Narrow upper jaw bones", "Transverse hypoplasia of maxilla", "Transverse maxillary deficiency", "Transverse maxillary insufficiency" ; oboInOwl:id "HP:0002010" ; a owl:Class ; rdfs:label "Narrow maxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002011 obo:IAO_0000115 "A structural abnormality of the central nervous system." ; oboInOwl:hasAlternativeId "HP:0002405", "HP:0002413", "HP:0002481", "HP:0007319" ; oboInOwl:hasDbXref "MSH:D002493", "SNOMEDCT_US:23853001", "UMLS:C0007682", "UMLS:C4021765" ; oboInOwl:hasExactSynonym "Abnormality of the central nervous system", "Morphological abnormality of the CNS", "Morphological abnormality of the central nervous system" ; oboInOwl:hasRelatedSynonym "Central nervous system disease" ; oboInOwl:id "HP:0002011" ; a owl:Class ; rdfs:label "Morphological central nervous system abnormality" ; rdfs:subClassOf obo:HP_0012639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002012 obo:IAO_0000115 "An abnormality of the viscera of the abdomen." ; oboInOwl:hasDbXref "UMLS:C4021764" ; oboInOwl:hasExactSynonym "Abnormality of the abdominal organs", "Gastrointestinal tract defects" ; oboInOwl:id "HP:0002012" ; a owl:Class ; rdfs:comment "The abdominal organs comprise the stomach, small and large intestines, liver, pancreas, bile tract, and spleen." ; rdfs:label "Abnormality of the abdominal organs" ; rdfs:subClassOf obo:HP_0025031 . obo:HP_0002013 obo:IAO_0000115 "Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions." ; oboInOwl:hasDbXref "MEDDRA:10047700", "MSH:D014839", "SNOMEDCT_US:249497008", "SNOMEDCT_US:300359004", "SNOMEDCT_US:422400008", "UMLS:C0042963" ; oboInOwl:hasExactSynonym "Emesis", "Throwing up", "Vomiting" ; oboInOwl:id "HP:0002013" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vomiting" ; rdfs:subClassOf obo:HP_0002017 . obo:HP_0002014 obo:IAO_0000115 "Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day." ; oboInOwl:hasDbXref "MSH:D003967", "SNOMEDCT_US:267060006", "SNOMEDCT_US:62315008", "UMLS:C0011991" ; oboInOwl:hasExactSynonym "Diarrhea", "Diarrhoea", "Watery stool" ; oboInOwl:id "HP:0002014" ; a owl:Class ; rdfs:label "Diarrhea" ; rdfs:subClassOf obo:HP_0011458 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001548 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002015 obo:IAO_0000115 "Difficulty in swallowing." ; oboInOwl:hasAlternativeId "HP:0002569" ; oboInOwl:hasDbXref "MEDDRA:10013950", "MSH:D003680", "SNOMEDCT_US:288939007", "SNOMEDCT_US:40739000", "UMLS:C0011168" ; oboInOwl:hasExactSynonym "Difficulty swallowing", "Poor swallowing", "Swallowing difficulties", "Swallowing difficulty" ; oboInOwl:hasRelatedSynonym "Deglutition disorder" ; oboInOwl:id "HP:0002015" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dysphagia" ; rdfs:subClassOf obo:HP_0012638, obo:HP_0025270 . obo:HP_0002017 obo:IAO_0000115 "Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea." ; oboInOwl:hasDbXref "SNOMEDCT_US:16932000", "UMLS:C0027498" ; oboInOwl:hasExactSynonym "Nausea and vomiting" ; oboInOwl:id "HP:0002017" ; a owl:Class ; rdfs:label "Nausea and vomiting" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0002018 obo:IAO_0000115 "A sensation of unease in the stomach together with an urge to vomit." ; oboInOwl:hasDbXref "MEDDRA:10028813", "MSH:D009325", "SNOMEDCT_US:422587007", "UMLS:C0027497" ; oboInOwl:hasExactSynonym "Nausea" ; oboInOwl:id "HP:0002018" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Nausea" ; rdfs:subClassOf obo:HP_0002017 . obo:HP_0002019 obo:IAO_0000115 "Infrequent or difficult evacuation of feces." ; oboInOwl:hasAlternativeId "HP:0002241", "HP:0003786" ; oboInOwl:hasDbXref "MSH:D003248", "SNOMEDCT_US:14760008", "SNOMEDCT_US:225595004", "UMLS:C0009806", "UMLS:C0237326" ; oboInOwl:hasExactSynonym "Constipation", "Costiveness", "Dyschezia" ; oboInOwl:id "HP:0002019" ; a owl:Class ; rdfs:label "Constipation" ; rdfs:subClassOf obo:HP_0011458 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000381 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002020 obo:IAO_0000115 "A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter." ; oboInOwl:hasAlternativeId "HP:0004793" ; oboInOwl:hasDbXref "MSH:D005764", "MSH:D006356", "SNOMEDCT_US:16331000", "SNOMEDCT_US:235595009", "SNOMEDCT_US:698065002", "UMLS:C0017168", "UMLS:C0018834" ; oboInOwl:hasExactSynonym "Acid reflux", "Acid reflux disease", "GERD", "Gastro-esophageal reflux", "Gastro-oesophageal reflux", "Gastroesophageal reflux disease", "Heartburn" ; oboInOwl:id "HP:0002020" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gastroesophageal reflux" ; rdfs:subClassOf obo:HP_0025270 . obo:HP_0002021 obo:IAO_0000115 "Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis, is an uncommon condition in infants characterized by abnormal thickening of the pylorus muscles in the stomach leading to gastric outlet obstruction. Clinically infants are well at birth. Then, at 3 to 6 weeks of age, the infants present with projectile vomiting, potentially leading to dehydration and weight loss." ; oboInOwl:hasDbXref "Fyler:4444", "MEDDRA:10037621", "MSH:D011707", "SNOMEDCT_US:367403001", "UMLS:C0034194" ; oboInOwl:hasExactSynonym "Infantile hypertrophic pyloric stenosis", "Pylorus stenosis" ; oboInOwl:id "HP:0002021" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Pyloric stenosis occurs in the first few months of life." ; rdfs:label "Pyloric stenosis" ; rdfs:subClassOf obo:HP_0004400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002023 obo:IAO_0000115 "Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract." ; oboInOwl:hasAlternativeId "HP:0001550" ; oboInOwl:hasDbXref "Fyler:4402", "Fyler:4443", "MEDDRA:10002120", "MSH:D001006", "SNOMEDCT_US:204712000", "SNOMEDCT_US:204731006", "UMLS:C0003466" ; oboInOwl:hasExactSynonym "Absent anus" ; oboInOwl:hasRelatedSynonym "Imperforate anus" ; oboInOwl:id "HP:0002023" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anal atresia" ; rdfs:subClassOf obo:HP_0034915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002024 obo:IAO_0000115 "Impaired ability to absorb one or more nutrients from the intestine." ; oboInOwl:hasAlternativeId "HP:0008270" ; oboInOwl:hasDbXref "UMLS:C3714745" ; oboInOwl:hasExactSynonym "Intestinal malabsorption", "Malabsorption" ; oboInOwl:id "HP:0002024" ; a owl:Class ; rdfs:label "Malabsorption" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050892 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002025 obo:IAO_0000115 "Abnormal narrowing of the anal opening." ; oboInOwl:hasDbXref "MEDDRA:10002176", "SNOMEDCT_US:250037002", "SNOMEDCT_US:69914001", "UMLS:C0262374" ; oboInOwl:hasExactSynonym "Narrowing of anal opening" ; oboInOwl:id "HP:0002025" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anal stenosis" ; rdfs:subClassOf obo:HP_0034915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000159 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002027 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen." ; oboInOwl:hasBroadSynonym "Gastro pain", "Gastrointestinal pain" ; oboInOwl:hasDbXref "MEDDRA:10000081", "MSH:D015746", "SNOMEDCT_US:21522001", "UMLS:C0000737" ; oboInOwl:hasExactSynonym "Abdominal pain", "Pain in stomach", "Stomach pain" ; oboInOwl:hasRelatedSynonym "Abdominal discomfort", "Upset stomach" ; oboInOwl:id "HP:0002027" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Abdominal pain can be crampy, achy, dull, intermittent or sharp. The terms stomach ache and stomach cramps are nonmedical terms often used to describe pain in the mid- or upper abdominal area, even though it is not the case that the (smooth) muscles of the stomach or the abdomen have cramps. Stomach pain is another layperson term commonly used to refer to abdominal pain." ; rdfs:label "Abdominal pain" ; rdfs:subClassOf obo:HP_0011458, obo:HP_0012531 . obo:HP_0002028 obo:IAO_0000115 "The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks." ; oboInOwl:hasDbXref "SNOMEDCT_US:236071009", "UMLS:C0401151" ; oboInOwl:hasExactSynonym "Chronic diarrhea", "Chronic diarrhoea" ; oboInOwl:hasRelatedSynonym "Diarrhea, recurrent", "Recurrent diarrhea", "Recurrent diarrhoea" ; oboInOwl:id "HP:0002028" ; a owl:Class ; rdfs:label "Chronic diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0002031 obo:IAO_0000115 "A structural abnormality of the esophagus." ; oboInOwl:hasDbXref "SNOMEDCT_US:69771008", "UMLS:C0266126" ; oboInOwl:hasExactSynonym "Abnormal oesophagus morphology", "Abnormality of esophagus structure", "Abnormality of oesophagus structure", "Anomaly of the esophagus", "Anomaly of the oesophagus" ; oboInOwl:id "HP:0002031" ; a owl:Class ; rdfs:label "Abnormal esophagus morphology" ; rdfs:subClassOf obo:HP_0012718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002032 obo:IAO_0000115 "A developmental defect resulting in complete obliteration of the lumen of the esophagus such that the esophagus ends in a blind pouch rather than connecting to the stomach." ; oboInOwl:hasDbXref "Fyler:4412", "MSH:D004933", "SNOMEDCT_US:26179002", "UMLS:C0014850" ; oboInOwl:hasExactSynonym "Birth defect in which part of esophagus did not develop", "Birth defect in which part of oesophagus did not develop" ; oboInOwl:id "HP:0002032" ; a owl:Class ; rdfs:label "Esophageal atresia" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0002589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002033 obo:IAO_0000115 "An inadequate sucking reflex, resulting in the difficult of newborns to be breast-fed." ; oboInOwl:hasDbXref "UMLS:C1837142" ; oboInOwl:hasExactSynonym "Poor suck", "Poor sucking", "Sucking weakness" ; oboInOwl:id "HP:0002033" ; a owl:Class ; rdfs:label "Poor suck" ; rdfs:subClassOf obo:HP_0008872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002034 obo:IAO_0000115 "An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus." ; oboInOwl:hasDbXref "SNOMEDCT_US:86993003", "UMLS:C0266210" ; oboInOwl:hasExactSynonym "Abnormality of the rectum", "Anomaly of the rectum" ; oboInOwl:id "HP:0002034" ; a owl:Class ; rdfs:label "Abnormal rectum morphology" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0012732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002035 obo:IAO_0000115 "Protrusion of the rectal mucous membrane through the anus." ; oboInOwl:hasDbXref "MEDDRA:10038077", "MSH:D012005", "SNOMEDCT_US:57773001", "UMLS:C0034888" ; oboInOwl:hasExactSynonym "Rectum protrudes through anus" ; oboInOwl:hasRelatedSynonym "Rectal prolapsed" ; oboInOwl:id "HP:0002035" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Rectal prolapse" ; rdfs:subClassOf obo:HP_0002034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002036 obo:IAO_0000115 "The presence of a hernia in which the upper part of the stomach, i.e., mainly the gastric cardia protrudes through the diaphragmatic esophageal hiatus." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:28:00Z" ; oboInOwl:hasDbXref "MEDDRA:10020028", "MSH:D006551", "SNOMEDCT_US:84089009", "UMLS:C3489393" ; oboInOwl:hasExactSynonym "Hiatal hernia", "Stomach hernia" ; oboInOwl:id "HP:0002036" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A tendency for the upper part of the stomach to herniate into the thorax because of a weakness of the esophageal hiatus, which is the hole in the diaphragm through which the esophagus passes. Hiatus hernia can be asymptomatic or can lead to acid reflux symptoms (heartburn)." ; rdfs:label "Hiatus hernia" ; rdfs:subClassOf obo:HP_0002577, obo:HP_0100790 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002163 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0016458 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002037 obo:IAO_0000115 "Inflammation, or an inflammatory state in the large intestine." ; oboInOwl:hasDbXref "MSH:D015212", "SNOMEDCT_US:24526004", "SNOMEDCT_US:302168000", "UMLS:C0021390", "UMLS:C0578878" ; oboInOwl:hasExactSynonym "Inflammation of the large intestine" ; oboInOwl:hasRelatedSynonym "Inflammatory bowel disease" ; oboInOwl:id "HP:0002037" ; a owl:Class ; rdfs:label "Inflammation of the large intestine" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0004386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002038 oboInOwl:hasDbXref "UMLS:C1839531" ; oboInOwl:id "HP:0002038" ; a owl:Class ; rdfs:label "Protein avoidance" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0002039 obo:IAO_0000115 "A lack or loss of appetite for food (as a medical condition)." ; oboInOwl:hasDbXref "MSH:D000855", "SNOMEDCT_US:79890006", "UMLS:C0003123" ; oboInOwl:hasExactSynonym "Anorexia" ; oboInOwl:id "HP:0002039" ; a owl:Class ; rdfs:comment "Note that this term does not refer to the condition anorexia nervosa (A disorder characterized by an obsessive desire to lose weight by refusing to eat)." ; rdfs:label "Anorexia" ; rdfs:subClassOf obo:HP_0011458 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0032098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0002040 obo:IAO_0000115 "Extreme dilation of the submucusoal veins in the lower portion of the esophagus." ; oboInOwl:hasDbXref "MEDDRA:10056091", "MSH:D004932", "SNOMEDCT_US:28670008", "UMLS:C0014867" ; oboInOwl:hasExactSynonym "Enlarged vein in esophagus", "Enlarged vein in oesophagus" ; oboInOwl:hasRelatedSynonym "Esophageal varices" ; oboInOwl:id "HP:0002040" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Esophageal varices are most often a consequence of portal hypertension." ; rdfs:label "Esophageal varix" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0002041 oboInOwl:hasDbXref "UMLS:C0743178" ; oboInOwl:hasExactSynonym "Intractable diarrhoea" ; oboInOwl:id "HP:0002041" ; a owl:Class ; rdfs:label "Intractable diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0002043 obo:IAO_0000115 "A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen." ; oboInOwl:hasDbXref "MSH:D004940", "SNOMEDCT_US:63305008", "UMLS:C0014866" ; oboInOwl:hasExactSynonym "Narrowing of esophagus due to inflammation and scar tissue", "Narrowing of oesophagus due to inflammation and scar tissue" ; oboInOwl:id "HP:0002043" ; a owl:Class ; rdfs:comment "Gastroesophageal reflux is a common cause of esophageal stricture." ; rdfs:label "Esophageal stricture" ; rdfs:subClassOf obo:HP_0010450 . obo:HP_0002044 obo:IAO_0000115 "A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration." ; oboInOwl:hasDbXref "MEDDRA:10048281", "MSH:D015043", "SNOMEDCT_US:53132006", "UMLS:C0043515" ; oboInOwl:id "HP:0002044" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Zollinger-Ellison syndrome may occur as a manifestation of multiple endocrine neoplasia type 1." ; rdfs:label "Zollinger-Ellison syndrome" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0002045 obo:IAO_0000115 "Reduced body temperature due to failed thermoregulation." ; oboInOwl:hasDbXref "MSH:D007035", "SNOMEDCT_US:386689009", "UMLS:C0020672" ; oboInOwl:hasExactSynonym "Abnormally low body temperature", "Hypothermia" ; oboInOwl:id "HP:0002045" ; a owl:Class ; rdfs:comment "A condition in which core temperature drops below that required for normal metabolism and body functions which is defined as 35.0 degrees C (95.0 degrees F)." ; rdfs:label "Hypothermia" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0002046 obo:IAO_0000115 "The inability to maintain a comfortable body temperature in warm or hot weather." ; oboInOwl:hasDbXref "SNOMEDCT_US:69215007", "UMLS:C0231274" ; oboInOwl:hasExactSynonym "Heat intolerance", "Intolerance to heat and fevers" ; oboInOwl:id "HP:0002046" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Heat intolerance tends to produce a feeling of being overheated and profuse diaphoresis (sweating). Many, but not all, cases of heat intolerance are related to thyrotoxicosis." ; rdfs:label "Heat intolerance" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0002047 obo:IAO_0000115 "Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise." ; oboInOwl:hasAlternativeId "HP:0004896" ; oboInOwl:hasDbXref "MSH:D008305", "SNOMEDCT_US:213026003", "SNOMEDCT_US:405501007", "UMLS:C0024591" ; oboInOwl:id "HP:0002047" ; a owl:Class ; rdfs:label "Malignant hyperthermia" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0002048 obo:IAO_0000115 "Atrophy of the cortex of the kidney." ; oboInOwl:hasDbXref "UMLS:C4025730" ; oboInOwl:id "HP:0002048" ; a owl:Class ; rdfs:label "Renal cortical atrophy" ; rdfs:subClassOf obo:HP_0011035, obo:HP_0012585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002049 obo:IAO_0000115 "A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia." ; oboInOwl:hasDbXref "MSH:D000141", "SNOMEDCT_US:24790002", "UMLS:C0268435" ; oboInOwl:hasExactSynonym "Proximal tubular acidosis", "Renal tubular acidosis, proximal", "Renal tubular acidosis, type II" ; oboInOwl:id "HP:0002049" ; a owl:Class ; rdfs:label "Proximal renal tubular acidosis" ; rdfs:subClassOf obo:HP_0001947 . obo:HP_0002050 oboInOwl:hasDbXref "UMLS:C1839782" ; oboInOwl:id "HP:0002050" ; a owl:Class ; rdfs:label "Macroorchidism, postpubertal" ; rdfs:subClassOf obo:HP_0000053 . obo:HP_0002054 oboInOwl:hasDbXref "UMLS:C1845107" ; oboInOwl:hasExactSynonym "Heavy brow of the face", "Heavy supraorbital ridge" ; oboInOwl:id "HP:0002054" ; a owl:Class ; rdfs:label "Heavy supraorbital ridges" ; rdfs:subClassOf obo:HP_0000336 . obo:HP_0002055 oboInOwl:hasDbXref "UMLS:C1844572" ; oboInOwl:id "HP:0002055" ; a owl:Class ; rdfs:label "Curved linear dimple below the lower lip" ; rdfs:subClassOf obo:HP_0000178 . obo:HP_0002056 obo:IAO_0000115 "An abnormality of the glabella." ; oboInOwl:hasDbXref "UMLS:C4021763" ; oboInOwl:hasExactSynonym "Abnormality of the area between the eyebrows", "Glabellar abnormality" ; oboInOwl:hasNarrowSynonym "Deformity of the area between the eyebrows", "Malformation of the area between the eyebrows" ; oboInOwl:id "HP:0002056" ; a owl:Class ; rdfs:label "Abnormality of the glabella" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016440 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002057 obo:IAO_0000115 "Forward protrusion of the glabella." ; oboInOwl:hasDbXref "UMLS:C1860247" ; oboInOwl:hasExactSynonym "Convex glabella", "Hyperplasia of glabella", "Prominent area between the eyebrows", "Protruding area between the eyebrows" ; oboInOwl:id "HP:0002057" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The glabella is the area of the forehead in the midline between the supraorbital ridges, just above the nasal root." ; rdfs:label "Prominent glabella" ; rdfs:subClassOf obo:HP_0002056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016440 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002058 obo:IAO_0000115 "A facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness." ; oboInOwl:hasAlternativeId "HP:0004647" ; oboInOwl:hasDbXref "SNOMEDCT_US:26432009", "UMLS:C0332615" ; oboInOwl:hasExactSynonym "Myopathic face", "Myopathic facial appearance" ; oboInOwl:id "HP:0002058" ; a owl:Class ; rdfs:label "Myopathic facies" ; rdfs:subClassOf obo:HP_0004673 . obo:HP_0002059 obo:IAO_0000115 "Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum." ; oboInOwl:hasAlternativeId "HP:0002422", "HP:0006890" ; oboInOwl:hasDbXref "SNOMEDCT_US:278849000", "SNOMEDCT_US:418143002", "SNOMEDCT_US:52522001", "UMLS:C0154671", "UMLS:C0235946", "UMLS:C4020860" ; oboInOwl:hasExactSynonym "Degeneration of cerebrum" ; oboInOwl:hasRelatedSynonym "Supratentorial atrophy" ; oboInOwl:id "HP:0002059" ; a owl:Class ; rdfs:comment "Atrophy may be progressive over time." ; rdfs:label "Cerebral atrophy" ; rdfs:subClassOf obo:HP_0007369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002060 obo:IAO_0000115 "Any structural abnormality of the telencephalon, which is also known as the cerebrum." ; oboInOwl:hasDbXref "UMLS:C4021762" ; oboInOwl:hasExactSynonym "Abnormality of the cerebrum", "Abnormality of the telencephalon", "Cerebral lesion" ; oboInOwl:id "HP:0002060" ; a owl:Class ; rdfs:label "Abnormal cerebral morphology" ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002061 obo:IAO_0000115 "Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis" ; oboInOwl:hasDbXref "SNOMEDCT_US:394679006", "UMLS:C1271100" ; oboInOwl:id "HP:0002061" ; a owl:Class ; rdfs:label "Lower limb spasticity" ; rdfs:subClassOf obo:HP_0034353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001257 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002062 obo:IAO_0000115 "Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts." ; oboInOwl:hasAlternativeId "HP:0012445" ; oboInOwl:hasDbXref "UMLS:C4020859", "UMLS:C4021761" ; oboInOwl:hasExactSynonym "Abnormality of the pyramidal tracts" ; oboInOwl:hasRelatedSynonym "Pyramidal tract disease" ; oboInOwl:id "HP:0002062" ; a owl:Class ; rdfs:comment "The pyramidal tracts comprise both the corticospinal and corticobulbar tracts." ; rdfs:label "Morphological abnormality of the pyramidal tract" ; rdfs:subClassOf obo:HP_0002011 . obo:HP_0002063 obo:IAO_0000115 "Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity." ; oboInOwl:hasDbXref "MSH:D009127", "SNOMEDCT_US:16046003", "UMLS:C0026837" ; oboInOwl:hasExactSynonym "Muscle rigidity", "Rigidity" ; oboInOwl:id "HP:0002063" ; a owl:Class ; rdfs:comment "Rigidity is often a manifestation of basal ganglia diseases." ; rdfs:label "Rigidity" ; rdfs:subClassOf obo:HP_0001276 . obo:HP_0002064 obo:IAO_0000115 "Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg." ; oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:9447003", "UMLS:C0231687" ; oboInOwl:hasExactSynonym "Spastic walk" ; oboInOwl:id "HP:0002064" ; a owl:Class ; rdfs:label "Spastic gait" ; rdfs:subClassOf obo:HP_0001257, obo:HP_0001288 . obo:HP_0002066 obo:IAO_0000115 "A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall." ; oboInOwl:hasAlternativeId "HP:0002379" ; oboInOwl:hasDbXref "MSH:D020234", "SNOMEDCT_US:25136009", "UMLS:C0751837" ; oboInOwl:hasExactSynonym "Ataxia of gait", "Ataxic gait", "Inability to coordinate movements when walking" ; oboInOwl:id "HP:0002066" ; a owl:Class ; rdfs:label "Gait ataxia" ; rdfs:subClassOf obo:HP_0001251, obo:HP_0001288 . obo:HP_0002067 obo:IAO_0000115 "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." ; oboInOwl:hasDbXref "MSH:D018476", "SNOMEDCT_US:399317006", "UMLS:C0233565" ; oboInOwl:hasExactSynonym "Slow movements", "Slowness of movements" ; oboInOwl:id "HP:0002067" ; a owl:Class ; rdfs:label "Bradykinesia" ; rdfs:subClassOf obo:HP_0002071 . obo:HP_0002068 oboInOwl:hasDbXref "UMLS:C4025729" ; oboInOwl:id "HP:0002068" ; a owl:Class ; rdfs:label "Neuromuscular dysphagia" ; rdfs:subClassOf obo:HP_0002015 . obo:HP_0002069 obo:IAO_0000115 "A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase." ; oboInOwl:hasAlternativeId "HP:0001306", "HP:0002407", "HP:0007252" ; oboInOwl:hasDbXref "MSH:D012640", "SNOMEDCT_US:54200006", "UMLS:C0494475" ; oboInOwl:hasExactSynonym "Bilateral convulsive seizures", "Generalised convulsion", "Generalised tonic-clonic seizure (without specification of onset)", "Generalized convulsion", "Generalized tonic-clonic seizure (without specification of onset)", "Grand mal", "Grand mal seizures", "Seizures, tonic-clonic", "Tonic-clonic convulsion", "Tonic-clonic convulsions" ; oboInOwl:id "HP:0002069" ; a owl:Class ; rdfs:comment "A tonic-clonic seizure may be generalised from onset or progress from a focal seizure to a bilateral tonic clonic seizure. This term describes the observed semiology of the seizure without specifying whether the onset is focal or generalized. Thus it can be used for coding bilateral tonic-clonic seizures when the onset is not known. This form of seizure was formerly commonly called grand mal seizure." ; rdfs:label "Bilateral tonic-clonic seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0002070 obo:IAO_0000115 "A kind of ataxia that affects movements of the extremities." ; oboInOwl:hasDbXref "MSH:D001259", "UMLS:C0750937" ; oboInOwl:hasExactSynonym "Appendicular ataxia" ; oboInOwl:id "HP:0002070" ; a owl:Class ; rdfs:comment "Limb ataxia is generally caused by lesions of the cerebellar hemispheres and associated pathways." ; rdfs:label "Limb ataxia" ; rdfs:subClassOf obo:HP_0001251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001251 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002071 obo:IAO_0000115 "A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless)." ; oboInOwl:hasAlternativeId "HP:0006810", "HP:0007113" ; oboInOwl:hasDbXref "MSH:D001480", "SNOMEDCT_US:43378000", "SNOMEDCT_US:76349003", "UMLS:C0015371", "UMLS:C0234133" ; oboInOwl:hasExactSynonym "Extrapyramidal dysfunction", "Extrapyramidal signs", "Extrapyramidal symptoms", "Extrapyramidal syndrome", "Extrapyramidal tract signs" ; oboInOwl:id "HP:0002071" ; a owl:Class ; rdfs:comment "The basal ganglia, paired subcortical masses of grey matter that form distinct nuclei, subserve motor functions that are distinct from those of the pyramidal (i.e., corticospinal) tract. This is a bundled term that is kept for historical reasons, but it is preferable to annotate the precise abnormalities observed." ; rdfs:label "Abnormality of extrapyramidal motor function" ; rdfs:subClassOf obo:HP_0011442 . obo:HP_0002072 obo:IAO_0000115 "Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities." ; oboInOwl:hasAlternativeId "HP:0002397" ; oboInOwl:hasDbXref "MSH:D002819", "SNOMEDCT_US:271700006", "UMLS:C0008489", "UMLS:C4020858" ; oboInOwl:hasExactSynonym "Choreic movements", "Choreiform movements" ; oboInOwl:hasRelatedSynonym "Choreatic disease" ; oboInOwl:id "HP:0002072" ; a owl:Class ; rdfs:label "Chorea" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 . obo:HP_0002073 oboInOwl:hasAlternativeId "HP:0001329", "HP:0002496", "HP:0007331" ; oboInOwl:hasDbXref "SNOMEDCT_US:230233000", "UMLS:C0393525" ; oboInOwl:hasExactSynonym "Cerebellar ataxia, progressive", "Progressive ataxia" ; oboInOwl:id "HP:0002073" ; a owl:Class ; rdfs:label "Progressive cerebellar ataxia" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0002074 obo:IAO_0000115 "Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the neuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." ; oboInOwl:hasDbXref "UMLS:C4020857", "UMLS:C4025728" ; oboInOwl:hasRelatedSynonym "Neuronal lipopigments" ; oboInOwl:id "HP:0002074" ; a owl:Class ; rdfs:label "Increased neuronal autofluorescent lipopigment" ; rdfs:subClassOf obo:HP_0011813 . obo:HP_0002075 obo:IAO_0000115 "A type of ataxia characterized by the impairment of the ability to perform rapidly alternating movements, such as pronating and supinating his or her hand on the dorsum of the other hand as rapidly as possible." ; oboInOwl:hasAlternativeId "HP:0002426" ; oboInOwl:hasDbXref "SNOMEDCT_US:23133003", "UMLS:C0234979" ; oboInOwl:hasExactSynonym "Difficulty performing quick and alternating movements", "Dysdiadochokinesia" ; oboInOwl:id "HP:0002075" ; a owl:Class ; rdfs:comment "Inability to perform rapid, alternating movements. Dysdiadochokinesis is generally related to a cerebellar lesion." ; rdfs:label "Dysdiadochokinesis" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0002076 obo:IAO_0000115 "Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms." ; oboInOwl:hasAlternativeId "HP:0007194" ; oboInOwl:hasDbXref "MSH:D008881", "SNOMEDCT_US:37796009", "UMLS:C0149931", "UMLS:C0744641" ; oboInOwl:hasExactSynonym "Intermittent migraine headaches", "Migraine", "Migraine headache", "Migraine headaches" ; oboInOwl:id "HP:0002076" ; a owl:Class ; rdfs:label "Migraine" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0002077 obo:IAO_0000115 "A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession." ; oboInOwl:hasDbXref "MSH:D020325", "SNOMEDCT_US:4473006", "UMLS:C0154723" ; oboInOwl:id "HP:0002077" ; a owl:Class ; rdfs:label "Migraine with aura" ; rdfs:subClassOf obo:HP_0002076 . obo:HP_0002078 obo:IAO_0000115 "Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting." ; oboInOwl:hasAlternativeId "HP:0007014" ; oboInOwl:hasDbXref "MSH:D001259", "SNOMEDCT_US:250067008", "UMLS:C0427190" ; oboInOwl:hasExactSynonym "Instability or lack of coordination of central trunk muscles", "Trunk ataxia" ; oboInOwl:id "HP:0002078" ; a owl:Class ; rdfs:comment "Truncal ataxia is generally caused by midline damage to the cerebellar vermis and associated pathways. Patients with truncal ataxia may not be able to sit or stand without support." ; rdfs:label "Truncal ataxia" ; rdfs:subClassOf obo:HP_0001251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001251 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002079 obo:IAO_0000115 "Underdevelopment of the corpus callosum." ; oboInOwl:hasAlternativeId "HP:0002319", "HP:0007026" ; oboInOwl:hasDbXref "SNOMEDCT_US:204043002", "UMLS:C0344482" ; oboInOwl:hasExactSynonym "Corpus callosum hypoplasia", "Hypoplasia of corpus callosum", "Hypoplastic corpus callosum", "Underdevelopment of part of brain called corpus callosum" ; oboInOwl:id "HP:0002079" ; a owl:Class ; rdfs:comment "The corpus callosum appears thin in midline views of the brain in neuroradiological images." ; rdfs:label "Hypoplasia of the corpus callosum" ; rdfs:subClassOf obo:HP_0007370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002080 obo:IAO_0000115 "A type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger)." ; oboInOwl:hasDbXref "MSH:D014202", "SNOMEDCT_US:30721006", "UMLS:C0234376", "UMLS:C4020856" ; oboInOwl:hasRelatedSynonym "Cerebellar tremor", "Terminal tremor" ; oboInOwl:id "HP:0002080" ; a owl:Class ; rdfs:label "Intention tremor" ; rdfs:subClassOf obo:HP_0030186 . obo:HP_0002083 obo:IAO_0000115 "Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia." ; oboInOwl:hasDbXref "MSH:D020326", "SNOMEDCT_US:56097005", "UMLS:C0338480" ; oboInOwl:id "HP:0002083" ; a owl:Class ; rdfs:comment "The definition of this term is based on the definition in the International Classification of Headache Disorders by the International Headache Society (PMID:15304572), which additionally stipulate that such headaches must have occurred at least five times and not other secondary cause must be apparent in order to make the diagnosis." ; rdfs:label "Migraine without aura" ; rdfs:subClassOf obo:HP_0002076 . obo:HP_0002084 obo:IAO_0000115 "A neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull." ; oboInOwl:hasAlternativeId "HP:0002736", "HP:0100664" ; oboInOwl:hasDbXref "MSH:D004677", "SNOMEDCT_US:253101008", "SNOMEDCT_US:48777005", "SNOMEDCT_US:55999004", "UMLS:C0014065" ; oboInOwl:hasExactSynonym "Bifid skull", "Cranium bifidum" ; oboInOwl:id "HP:0002084" ; a owl:Class ; rdfs:comment "A congenital gap in the skull that usually results in a protrusion of brain material." ; rdfs:label "Encephalocele" ; rdfs:subClassOf obo:HP_0002011, obo:HP_0011815, obo:HP_0034237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002085 obo:IAO_0000115 "A type of encephalocele (that is, a a protrusion of part of the cranial contents including brain tissue through a congenital opening in the cranium, typically covered with skin or mucous membrane) in the occipital region of the skull. Occipital encephalocele presents as a midline swelling over the occipital bone. It is usually covered with normal full-thickness scalp." ; oboInOwl:hasAlternativeId "HP:0007051", "HP:0007357" ; oboInOwl:hasDbXref "MSH:D004677", "SNOMEDCT_US:42376006", "UMLS:C0014067" ; oboInOwl:hasExactSynonym "Brain tissue sticks out through back of skull", "Occipital meningoencephalocele", "Posterior encephalocele" ; oboInOwl:id "HP:0002085" ; a owl:Class ; rdfs:label "Occipital encephalocele" ; rdfs:subClassOf obo:HP_0002084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002086 obo:IAO_0000115 "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." ; oboInOwl:hasDbXref "UMLS:C4018871" ; oboInOwl:hasExactSynonym "Respiratory abnormality" ; oboInOwl:id "HP:0002086" ; a owl:Class ; rdfs:label "Abnormality of the respiratory system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002087 obo:IAO_0000115 "An abnormality of the upper respiratory tract." ; oboInOwl:hasDbXref "UMLS:C4025727" ; oboInOwl:hasExactSynonym "Abnormality of the upper respiratory tract", "Upper respiratory tract issues" ; oboInOwl:id "HP:0002087" ; a owl:Class ; rdfs:label "Abnormality of the upper respiratory tract" ; rdfs:subClassOf obo:HP_0012252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001557 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002088 obo:IAO_0000115 "Any structural anomaly of the lung." ; oboInOwl:hasDbXref "MSH:D008171", "SNOMEDCT_US:19829001", "UMLS:C0024115", "UMLS:C4021760" ; oboInOwl:hasExactSynonym "Abnormality of lung structure", "Abnormality of the lungs", "Abnormally shaped lung", "Unusal lung shape" ; oboInOwl:hasRelatedSynonym "Lung disease" ; oboInOwl:id "HP:0002088" ; a owl:Class ; rdfs:label "Abnormal lung morphology" ; rdfs:subClassOf obo:HP_0012252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002089 oboInOwl:hasDbXref "SNOMEDCT_US:80825009", "UMLS:C0265783" ; oboInOwl:hasExactSynonym "Hypoplastic lung", "Hypoplastic lungs", "Lung hypoplasia", "Poorly developed lungs", "Small lung", "Underdeveloped lung" ; oboInOwl:id "HP:0002089" ; a owl:Class ; rdfs:label "Pulmonary hypoplasia" ; rdfs:subClassOf obo:HP_0006703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002090 obo:IAO_0000115 "Inflammation of any part of the lung parenchyma." ; oboInOwl:hasDbXref "MSH:D011014", "SNOMEDCT_US:233604007", "UMLS:C0032285" ; oboInOwl:hasExactSynonym "Pneumonia" ; oboInOwl:id "HP:0002090" ; a owl:Class ; rdfs:label "Pneumonia" ; rdfs:subClassOf obo:HP_0011947, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002091 obo:IAO_0000115 "A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus." ; oboInOwl:hasAlternativeId "HP:0002111" ; oboInOwl:hasDbXref "SNOMEDCT_US:36485005", "UMLS:C0085581", "UMLS:C3277226" ; oboInOwl:hasExactSynonym "Restrictive deficit on pulmonary function testing", "Restrictive deficit on pulmonary function tests", "Restrictive respiratory disease", "Restrictive respiratory insufficiency", "Restrictive respiratory syndrome", "Spirometric restriction", "Stiff lung or chest wall causing decreased lung volume" ; oboInOwl:hasRelatedSynonym "Restrictive lung disease" ; oboInOwl:id "HP:0002091" ; a owl:Class ; rdfs:comment "The most commonly used term for this feature is restrictive lung disease, but we choose the term Restrictive ventilatory defect to emphasize that this term refers to a phenotypic feature rather than a disease entity." ; rdfs:label "Restrictive ventilatory defect" ; rdfs:subClassOf obo:HP_0002795, obo:HP_0030878 . obo:HP_0002092 obo:IAO_0000115 "Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position." ; oboInOwl:hasAlternativeId "HP:0006546" ; oboInOwl:hasDbXref "MSH:D006976", "MSH:D065627", "SNOMEDCT_US:11399002", "SNOMEDCT_US:697898008", "SNOMEDCT_US:70995007", "UMLS:C0020542", "UMLS:C2973725", "UMLS:C3203102" ; oboInOwl:hasExactSynonym "Increased blood pressure in blood vessels of lungs", "Pulmonary artery hypertension" ; oboInOwl:hasRelatedSynonym "Primary pulmonary hypertension" ; oboInOwl:id "HP:0002092" ; a owl:Class ; rdfs:comment "Pulmonary hypertension can be secondary to known cardiac, pulmonary, or hepatic disease. If no cause is identifiable, the term primary pulmonary hypertension is used." ; rdfs:label "Pulmonary arterial hypertension" ; rdfs:subClassOf obo:HP_0033578 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001576 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0002093 oboInOwl:hasAlternativeId "HP:0004893", "HP:0005937", "HP:0006542" ; oboInOwl:hasDbXref "MSH:D012131", "SNOMEDCT_US:409623005", "UMLS:C0035229", "UMLS:C4020855" ; oboInOwl:hasExactSynonym "Respiratory impairment" ; oboInOwl:hasRelatedSynonym "Respiratory function loss" ; oboInOwl:id "HP:0002093" ; a owl:Class ; rdfs:label "Respiratory insufficiency" ; rdfs:subClassOf obo:HP_0002795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002094 obo:IAO_0000115 "Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale." ; oboInOwl:hasDbXref "MSH:D004417", "SNOMEDCT_US:230145002", "SNOMEDCT_US:267036007", "UMLS:C0013404" ; oboInOwl:hasExactSynonym "Abnormal breathing", "Breathing difficulty", "Difficult to breathe", "Difficulty breathing", "Dyspnoea", "Shortness of breath", "Trouble breathing" ; oboInOwl:hasRelatedSynonym "Panting" ; oboInOwl:id "HP:0002094" ; a owl:Class ; rdfs:label "Dyspnea" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0002097 oboInOwl:hasAlternativeId "HP:0006534" ; oboInOwl:hasDbXref "MSH:D011656", "SNOMEDCT_US:87433001", "UMLS:C0034067" ; oboInOwl:hasExactSynonym "Pulmonary emphysema" ; oboInOwl:id "HP:0002097" ; a owl:Class ; rdfs:label "Emphysema" ; rdfs:subClassOf obo:HP_0002088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_31 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002098 obo:IAO_0000115 "Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea." ; oboInOwl:hasAlternativeId "HP:0002880" ; oboInOwl:hasDbXref "MSH:D004417", "SNOMEDCT_US:230145002", "SNOMEDCT_US:267036007", "SNOMEDCT_US:271825005", "UMLS:C0013404", "UMLS:C0476273" ; oboInOwl:hasExactSynonym "Breathing difficulties", "Labored breathing", "Laboured breathing", "Respiratory difficulties" ; oboInOwl:id "HP:0002098" ; a owl:Class ; rdfs:label "Respiratory distress" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0002099 obo:IAO_0000115 "Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing." ; oboInOwl:hasAlternativeId "HP:0002112" ; oboInOwl:hasDbXref "MSH:D001249", "SNOMEDCT_US:195967001", "SNOMEDCT_US:991000119106", "UMLS:C0004096", "UMLS:C3714497" ; oboInOwl:hasExactSynonym "Asthma", "Bronchial asthma" ; oboInOwl:hasRelatedSynonym "Reactive airway disease" ; oboInOwl:id "HP:0002099" ; a owl:Class ; rdfs:label "Asthma" ; rdfs:subClassOf obo:HP_0002795, obo:HP_0100326 . obo:HP_0002100 obo:IAO_0000115 "Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia." ; oboInOwl:hasAlternativeId "HP:0002106" ; oboInOwl:hasDbXref "SNOMEDCT_US:430969000", "UMLS:C0747651" ; oboInOwl:hasExactSynonym "Recurrent pneumonia due to aspiration," ; oboInOwl:id "HP:0002100" ; a owl:Class ; rdfs:label "Recurrent aspiration pneumonia" ; rdfs:subClassOf obo:HP_0011951 . obo:HP_0002101 obo:IAO_0000115 "A developmental defect in the formation of pulmonary lobes." ; oboInOwl:hasAlternativeId "HP:0006525", "HP:0009753" ; oboInOwl:hasDbXref "SNOMEDCT_US:91842005", "UMLS:C0685695" ; oboInOwl:hasExactSynonym "Abnormal pulmonary lobation", "Defective lung lobation", "Lung segmentation defects" ; oboInOwl:id "HP:0002101" ; a owl:Class ; rdfs:label "Abnormal lung lobation" ; rdfs:subClassOf obo:HP_4000059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002102 obo:IAO_0000115 "Inflammation of the pleura." ; oboInOwl:hasDbXref "MSH:D010998", "SNOMEDCT_US:196075003", "UMLS:C0032231" ; oboInOwl:hasExactSynonym "Inflammation of tissues lining lungs and chest", "Pleurisy" ; oboInOwl:id "HP:0002102" ; a owl:Class ; rdfs:label "Pleuritis" ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0002103 obo:IAO_0000115 "An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls." ; oboInOwl:hasDbXref "UMLS:C4025726" ; oboInOwl:hasExactSynonym "Abnormality of the pleura" ; oboInOwl:id "HP:0002103" ; a owl:Class ; rdfs:label "Abnormal pleura morphology" ; rdfs:subClassOf obo:HP_0002088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002104 obo:IAO_0000115 "Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event." ; oboInOwl:hasAlternativeId "HP:0005936", "HP:0005958" ; oboInOwl:hasDbXref "MSH:D001049", "SNOMEDCT_US:1023001", "SNOMEDCT_US:248583008", "UMLS:C0003578" ; oboInOwl:hasExactSynonym "Absence of spontaneous respiration", "Apneic episodes", "Apnoea" ; oboInOwl:id "HP:0002104" ; a owl:Class ; rdfs:label "Apnea" ; rdfs:subClassOf obo:HP_0002793 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002105 obo:IAO_0000115 "Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs." ; oboInOwl:hasDbXref "MSH:D006469", "SNOMEDCT_US:66857006", "SNOMEDCT_US:6686005", "UMLS:C0019079" ; oboInOwl:hasExactSynonym "Coughing up blood", "Haemoptysis" ; oboInOwl:hasRelatedSynonym "Coughing up blood or blood-stained mucus" ; oboInOwl:id "HP:0002105" ; a owl:Class ; rdfs:label "Hemoptysis" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0002107 obo:IAO_0000115 "Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung." ; oboInOwl:hasDbXref "MSH:D011030", "SNOMEDCT_US:36118008", "UMLS:C0032326" ; oboInOwl:hasExactSynonym "Collapsed lung" ; oboInOwl:id "HP:0002107" ; a owl:Class ; rdfs:label "Pneumothorax" ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0002108 obo:IAO_0000115 "Pneumothorax occurring without traumatic injury to the chest or lung." ; oboInOwl:hasDbXref "MSH:D011030", "SNOMEDCT_US:80423007", "UMLS:C0149781" ; oboInOwl:hasExactSynonym "Spontaneous collapsed lung" ; oboInOwl:id "HP:0002108" ; a owl:Class ; rdfs:label "Spontaneous pneumothorax" ; rdfs:subClassOf obo:HP_0002107 . obo:HP_0002109 obo:IAO_0100001 "HP:0025426" ; oboInOwl:id "HP:0002109" ; a owl:Class ; rdfs:label "obsolete Abnormality of the bronchi" ; owl:deprecated true . obo:HP_0002110 obo:IAO_0000115 "Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways." ; oboInOwl:hasDbXref "MSH:D001987", "SNOMEDCT_US:12295008", "UMLS:C0006267" ; oboInOwl:hasExactSynonym "Permanent enlargement of the airways of the lungs" ; oboInOwl:id "HP:0002110" ; a owl:Class ; rdfs:label "Bronchiectasis" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0002111 obo:IAO_0100001 "HP:0002091" ; oboInOwl:id "HP:0002111" ; a owl:Class ; rdfs:label "obsolete Restrictive deficit on pulmonary function testing" ; owl:deprecated true . obo:HP_0002113 oboInOwl:hasDbXref "UMLS:C0235896" ; oboInOwl:hasExactSynonym "Lung infiltrates", "Pulmonic infiltration" ; oboInOwl:id "HP:0002113" ; a owl:Class ; rdfs:label "Pulmonary infiltrates" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0002118 obo:IAO_0000115 "Any structural abnormality of the cerebral ventricles." ; oboInOwl:hasDbXref "UMLS:C4025724" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral ventricles" ; oboInOwl:id "HP:0002118" ; a owl:Class ; rdfs:label "Abnormal cerebral ventricle morphology" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004086 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002119 obo:IAO_0000115 "An increase in size of the ventricular system of the brain." ; oboInOwl:hasAlternativeId "HP:0002447", "HP:0005691", "HP:0007071" ; oboInOwl:hasDbXref "UMLS:C3278923" ; oboInOwl:hasExactSynonym "Cerebral ventricular dilatation", "Dilated cerebral ventricle", "Dilated cerebral ventricles", "Dilated ventricles", "Enlarged cerebral ventricles", "Enlarged ventricles", "Enlarged ventricular system", "Large cerebral ventricles and cisternae", "Ventricular dilatation" ; oboInOwl:id "HP:0002119" ; a owl:Class ; rdfs:label "Ventriculomegaly" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004086 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002120 obo:IAO_0000115 "Atrophy of the cortex of the cerebrum." ; oboInOwl:hasAlternativeId "HP:0006823", "HP:0006835" ; oboInOwl:hasDbXref "SNOMEDCT_US:278849000", "UMLS:C0235946" ; oboInOwl:hasExactSynonym "Cerebral cortex atrophy", "Cortical atrophy", "Decrease in size of the outer layer of the brain due to loss of brain cells" ; oboInOwl:id "HP:0002120" ; a owl:Class ; rdfs:comment "Cortical atrophy is a finding that can be demonstrated by computer tomography or magnetic resonance imaging." ; rdfs:label "Cerebral cortical atrophy" ; rdfs:subClassOf obo:HP_0002059, obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002121 obo:IAO_0000115 "A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterised by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features." ; oboInOwl:hasAlternativeId "HP:0007143", "HP:0011148" ; oboInOwl:hasDbXref "MSH:D004832", "SNOMEDCT_US:230413002", "SNOMEDCT_US:432241000124101", "SNOMEDCT_US:50866000", "SNOMEDCT_US:79631006", "UMLS:C0014553" ; oboInOwl:hasExactSynonym "Absence seizure", "Absence seizures", "Brief seizures with staring spells", "Generalised non-motor (absence) seizure", "Generalised non-motor seizure", "Petit mal", "Petit mal seizure", "Petit mal seizures" ; oboInOwl:id "HP:0002121" ; a owl:Class ; rdfs:comment "in 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (over 80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination; see Dialeptic seizure." ; rdfs:label "Generalized non-motor (absence) seizure" ; rdfs:subClassOf obo:HP_0002197, obo:HP_0011146, obo:HP_0033259 . obo:HP_0002123 obo:IAO_0000115 "A generalized myoclonic seizure is a type of generalized motor seizure characterised by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." ; oboInOwl:hasAlternativeId "HP:0006869", "HP:0006902", "HP:0007075", "HP:0007202", "HP:0007284", "HP:0007294" ; oboInOwl:hasDbXref "MSH:D004831", "MSH:D020191", "SNOMEDCT_US:192992007", "SNOMEDCT_US:267581004", "SNOMEDCT_US:37356005", "UMLS:C0014550", "UMLS:C0751778", "UMLS:C4021759" ; oboInOwl:hasExactSynonym "Generalised epileptic myoclonus", "Generalised myoclonic seizure", "Generalised myoclonic seizures", "Generalized epileptic myoclonus", "Generalized myoclonic seizures", "Myoclonus seizures" ; oboInOwl:hasRelatedSynonym "Myoclonic epilepsy, progressive" ; oboInOwl:id "HP:0002123" ; a owl:Class ; rdfs:label "Generalized myoclonic seizure" ; rdfs:subClassOf obo:HP_0032677, obo:HP_0032794 . obo:HP_0002126 obo:IAO_0000115 "Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds)." ; oboInOwl:hasDbXref "MSH:D065706", "SNOMEDCT_US:4945003", "UMLS:C0266464" ; oboInOwl:hasExactSynonym "More grooves in brain" ; oboInOwl:id "HP:0002126" ; a owl:Class ; rdfs:comment "Polymicrogyria, one of the most common malformations of cortical development, is characterized histologically by the appearance of an excessive number of small cortical folds, often fused together, with disordered cortical lamination." ; rdfs:label "Polymicrogyria" ; rdfs:subClassOf obo:HP_0002536 . obo:HP_0002127 obo:IAO_0000115 "Any structural anomaly that affects the upper motor neuron." ; oboInOwl:hasDbXref "UMLS:C4025723" ; oboInOwl:hasExactSynonym "Abnormal shape of upper motor neuron" ; oboInOwl:id "HP:0002127" ; a owl:Class ; rdfs:comment """previous def: 'has part' some (quality and ('inheres in' some 'Upper motor neuron (adult human)') and ('has modifier' some abnormal))""" ; rdfs:label "Abnormal upper motor neuron morphology" ; rdfs:subClassOf obo:HP_0002450 . obo:HP_0002131 obo:IAO_0000115 "Periodic spells of incoordination and imbalance, that is, episodes of ataxia typically lasting from 10 minutes to several hours or days." ; oboInOwl:hasAlternativeId "HP:0006862", "HP:0007152", "HP:0007214" ; oboInOwl:hasDbXref "MSH:C580065", "SNOMEDCT_US:421455009", "UMLS:C1720189" ; oboInOwl:hasExactSynonym "Intermittent cerebellar ataxia", "Paroxysmal ataxia" ; oboInOwl:id "HP:0002131" ; a owl:Class ; rdfs:label "Episodic ataxia" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0002132 obo:IAO_0000115 "A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system." ; oboInOwl:hasDbXref "MSH:D065708", "UMLS:C4082173" ; oboInOwl:hasExactSynonym "Cavity within brain" ; oboInOwl:id "HP:0002132" ; a owl:Class ; rdfs:comment "Porencephaly is usually the result of damage from stroke or infection after birth, but may also be the result of a developmental defect. Porencephaly is often associated with various ophthalmic and neurologic signs, including visual-field defects, abnormal pupillary responses, optic nerve hypoplasia, decreased vision, nystagmus, strabismus, hemi-inattention, seizures, and mental deficiencies." ; rdfs:label "Porencephalic cyst" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0002133 obo:IAO_0000115 "Status epilepticus is a type of prolonged seizure resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). It is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures." ; oboInOwl:hasDbXref "MSH:D013226", "SNOMEDCT_US:230456007", "UMLS:C0038220" ; oboInOwl:hasExactSynonym "Prolonged seizure", "Repeated seizure without recovery", "Repeated seizures without recovery between them" ; oboInOwl:id "HP:0002133" ; a owl:Class ; rdfs:comment "In 2015 the ILAE Task Force on Classification of Status Epilepticus concluded that the evidence to define time points 1 and 2 in humans was incomplete. For tonic-clonic status epilepticus t1 is defined as 5 minutes and t2 as 30 minutes. For focal status epilepticus with impaired consciousness t1 is defined as 10 minutes and t2 over 60 minutes. For absence status epilepticus t1 is defined as 10-15 minutes and t2 is unknown." ; rdfs:label "Status epilepticus" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0002134 obo:IAO_0000115 "Abnormality of the basal ganglia." ; oboInOwl:hasAlternativeId "HP:0006952", "HP:0007257" ; oboInOwl:hasDbXref "MSH:D001480", "SNOMEDCT_US:70835005", "UMLS:C0004782" ; oboInOwl:hasExactSynonym "Abnormality of the basal ganglia", "Anomaly of the basal ganglia", "Basal ganglia disease" ; oboInOwl:id "HP:0002134" ; a owl:Class ; rdfs:comment "The basal ganglia are a group of nuclei (striatum, pallidum substantia nigra, and the subthalamic nucleus) at the base of the forebrain that are connected to the cerebral cortex, the thalamus, and other areas. The basal ganglia subserve motor functions that are distinct from those of the pyramidal (corticospinal) tract, for which reason neurologic abnormalities caused by lesions to the basal ganglia are often referred to as extrapyramidal." ; rdfs:label "Abnormal basal ganglia morphology" ; rdfs:subClassOf obo:HP_0010993 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002135 obo:IAO_0000115 "The presence of calcium deposition affecting one or more structures of the basal ganglia." ; oboInOwl:hasAlternativeId "HP:0002485" ; oboInOwl:hasDbXref "UMLS:C1389280" ; oboInOwl:hasExactSynonym "Basal ganglia calcifications", "Basal ganglion calcification", "Calcification of the basal ganglia" ; oboInOwl:id "HP:0002135" ; a owl:Class ; rdfs:label "Basal ganglia calcification" ; rdfs:subClassOf obo:HP_0002134, obo:HP_0002514 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002136 obo:IAO_0000115 "An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia." ; oboInOwl:hasDbXref "UMLS:C0856863" ; oboInOwl:hasExactSynonym "Broad based gait", "Wide based gait", "Wide based walk", "Wide-based gait" ; oboInOwl:id "HP:0002136" ; a owl:Class ; rdfs:label "Broad-based gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002138 obo:IAO_0000115 "Hemorrhage occurring between the arachnoid mater and the pia mater." ; oboInOwl:hasDbXref "MSH:D013345", "SNOMEDCT_US:21454007", "UMLS:C0038525" ; oboInOwl:hasExactSynonym "Subarachnoid haemorrhage" ; oboInOwl:id "HP:0002138" ; a owl:Class ; rdfs:comment "Bleeding into the subarachnoid space the area between the arachnoid membrane and the pia mater surrounding the brain. Subarachnoid hemorrhage may occur spontaneously, usually from a ruptured cerebral aneurysm, or may result from head injury." ; rdfs:label "Subarachnoid hemorrhage" ; rdfs:subClassOf obo:HP_0002170, obo:HP_0012703 . obo:HP_0002139 obo:IAO_0000115 "A defect of development of the brain characterized by congenital absence of the part of the brain that includes the olfactory bulbs, tracts, and other structures associated with the sense of smell." ; oboInOwl:hasDbXref "MSH:D016142", "UMLS:C0078982" ; oboInOwl:hasExactSynonym "Arhinencephaly" ; oboInOwl:id "HP:0002139" ; a owl:Class ; rdfs:label "Arrhinencephaly" ; rdfs:subClassOf obo:HP_0100547 . obo:HP_0002140 obo:IAO_0000115 "Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured." ; oboInOwl:hasDbXref "SNOMEDCT_US:422504002", "UMLS:C0948008" ; oboInOwl:hasExactSynonym "Ischaemic stroke" ; oboInOwl:id "HP:0002140" ; a owl:Class ; rdfs:label "Ischemic stroke" ; rdfs:subClassOf obo:HP_0001297, obo:HP_0002637, obo:HP_0025722 . obo:HP_0002141 oboInOwl:hasAlternativeId "HP:0100683" ; oboInOwl:hasDbXref "UMLS:C1836150" ; oboInOwl:hasExactSynonym "Abnormality of balance", "Abnormality of equilibrium", "Imbalanced walk" ; oboInOwl:id "HP:0002141" ; a owl:Class ; rdfs:label "Gait imbalance" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002143 obo:IAO_0000115 "A structural abnormality of the spinal cord (myelon)." ; oboInOwl:hasDbXref "MSH:D013118", "SNOMEDCT_US:48522003", "UMLS:C0037928", "UMLS:C4025722" ; oboInOwl:hasExactSynonym "Abnormality of the spinal cord" ; oboInOwl:hasRelatedSynonym "Spinal cord disease", "Spinal cord pathology" ; oboInOwl:id "HP:0002143" ; a owl:Class ; rdfs:label "Abnormal spinal cord morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002144 obo:IAO_0000115 "During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord." ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:70534000", "UMLS:C0080218" ; oboInOwl:hasExactSynonym "Occult spinal dysraphism" ; oboInOwl:id "HP:0002144" ; a owl:Class ; rdfs:label "Tethered cord" ; rdfs:subClassOf obo:HP_0031938 . obo:HP_0002145 obo:IAO_0000115 "A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders." ; oboInOwl:hasDbXref "MSH:D057180", "SNOMEDCT_US:230270009", "UMLS:C0338451" ; oboInOwl:id "HP:0002145" ; a owl:Class ; rdfs:label "Frontotemporal dementia" ; rdfs:subClassOf obo:HP_0000726 . obo:HP_0002148 obo:IAO_0000115 "An abnormally decreased phosphate concentration in the blood." ; oboInOwl:hasDbXref "MSH:D017674", "SNOMEDCT_US:4996001", "UMLS:C0085682" ; oboInOwl:hasExactSynonym "Hypophosphataemia", "Low blood phosphate level" ; oboInOwl:id "HP:0002148" ; a owl:Class ; rdfs:label "Hypophosphatemia" ; rdfs:subClassOf obo:HP_0100529 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002149 obo:IAO_0000115 "An abnormally high level of uric acid in the blood." ; oboInOwl:hasDbXref "MSH:D033461", "SNOMEDCT_US:35885006", "UMLS:C0740394" ; oboInOwl:hasExactSynonym "High blood uric acid level", "Hyperuricaemia" ; oboInOwl:id "HP:0002149" ; a owl:Class ; rdfs:label "Hyperuricemia" ; rdfs:subClassOf obo:HP_0002157, obo:HP_0010932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002150 oboInOwl:hasDbXref "MSH:D053565", "SNOMEDCT_US:71938000", "UMLS:C0020438" ; oboInOwl:hasExactSynonym "Elevated urine calcium levels", "Hypercalcinuria" ; oboInOwl:id "HP:0002150" ; a owl:Class ; rdfs:label "Hypercalciuria" ; rdfs:subClassOf obo:HP_0011280 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002151 obo:IAO_0000115 "Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35)." ; oboInOwl:hasAlternativeId "HP:0003638" ; oboInOwl:hasBroadSynonym "Higher than normal levels of lactate in blood" ; oboInOwl:hasDbXref "UMLS:C1836440" ; oboInOwl:hasExactSynonym "Increased blood lactate" ; oboInOwl:id "HP:0002151" ; a owl:Class ; rdfs:label "Increased serum lactate" ; rdfs:subClassOf obo:HP_0001941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002152 obo:IAO_0000115 "An increased concentration of proteins in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:37064009", "UMLS:C0267988" ; oboInOwl:id "HP:0002152" ; a owl:Class ; rdfs:label "Hyperproteinemia" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002153 obo:IAO_0000115 "An abnormally increased potassium concentration in the blood." ; oboInOwl:hasDbXref "MSH:D006947", "SNOMEDCT_US:14140009", "SNOMEDCT_US:166689004", "SNOMEDCT_US:238142003", "UMLS:C0020461" ; oboInOwl:hasExactSynonym "Elevated serum potassium levels" ; oboInOwl:id "HP:0002153" ; a owl:Class ; rdfs:label "Hyperkalemia" ; rdfs:subClassOf obo:HP_0011042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002154 obo:IAO_0000115 "An elevated concentration of glycine in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:64654004", "UMLS:C0268559" ; oboInOwl:hasExactSynonym "Elevated blood glycine levels", "Hyperglycinaemia" ; oboInOwl:id "HP:0002154" ; a owl:Class ; rdfs:comment "Normal blood glycine levels are around 200-250 micromole per liter." ; rdfs:label "Hyperglycinemia" ; rdfs:subClassOf obo:HP_0010895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15428 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002155 obo:IAO_0000115 "An abnormal increase in the level of triglycerides in the blood." ; oboInOwl:hasAlternativeId "HP:0003082", "HP:0008174", "HP:0008332" ; oboInOwl:hasDbXref "UMLS:C1522137" ; oboInOwl:hasExactSynonym "Increased circulating Tg levels", "Increased plasma Tg levels", "Increased plasma triglycerides", "Increased serum triglycerides", "Increased triglycerides" ; oboInOwl:id "HP:0002155" ; a owl:Class ; rdfs:label "Hypertriglyceridemia" ; rdfs:subClassOf obo:HP_0003077 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17855 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002156 obo:IAO_0000115 "An increased concentration of homocystine in the urine." ; oboInOwl:hasDbXref "MSH:D006712", "SNOMEDCT_US:11282001", "UMLS:C0019880" ; oboInOwl:hasExactSynonym "High urine homocystine levels" ; oboInOwl:id "HP:0002156" ; a owl:Class ; rdfs:comment "Homocystine is a disulfide derivate of homocysteine (a precursor of cysteine). Patients with homocystinuria have a clinical phenotype similar to that of patients affected by Marfan syndrome (pectus excavatum, dislocated lenses, etc). This term does not describe the disease entity, but rather the finding of an increased concentration of homocystine in urine, which can be easily detected by a sensitive test for disulphide compounds (the cyanide-nitroprusside reaction) and using chromatographic techniques. Homocystinuria can be caused by biochemical defects including cystathionine B-synthase deficiency, N5-methyltetrahydrofolate:homocystine methyltransferase deficiency, N5,10-methylentetrahydrofolate reductase deficiency, and methhylcobalamin deficiency." ; rdfs:label "Homocystinuria" ; rdfs:subClassOf obo:HP_0033095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002157 obo:IAO_0000115 "An increased concentration of nitrogen compounds in the blood." ; oboInOwl:hasDbXref "MSH:D053099", "SNOMEDCT_US:445009001", "UMLS:C0242528" ; oboInOwl:hasExactSynonym "Azotaemia" ; oboInOwl:id "HP:0002157" ; a owl:Class ; rdfs:comment "Abnormal levels of nitrogen-containing compounds, such as urea and creatinine." ; rdfs:label "Azotemia" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_51143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002159 obo:IAO_0000115 "An increased concentration of heparan sulfates in the urine." ; oboInOwl:hasDbXref "UMLS:C1854827" ; oboInOwl:hasExactSynonym "Heparan sulphate excretion in urine" ; oboInOwl:id "HP:0002159" ; a owl:Class ; rdfs:label "Heparan sulfate excretion in urine" ; rdfs:subClassOf obo:HP_0008155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28815 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002160 obo:IAO_0000115 "An increased concentration of homocystine in the blood." ; oboInOwl:hasDbXref "UMLS:C3806347" ; oboInOwl:hasExactSynonym "Elevated blood homocystine", "Homocystinemia" ; oboInOwl:id "HP:0002160" ; a owl:Class ; rdfs:comment """Homocystine is a disulfide derivative of homocysteine (a precursor of cysteine). Hyperhomocystinemic patients show blood homocystine levels in the range of 50-200 micromolar.""" ; rdfs:label "Hyperhomocystinemia" ; rdfs:subClassOf obo:HP_0010919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002161 obo:IAO_0000115 "An increased concentration of lysine in the blood." ; oboInOwl:hasDbXref "MSH:D020167", "SNOMEDCT_US:58558003", "UMLS:C0268553" ; oboInOwl:hasExactSynonym "Elevated blood lysine" ; oboInOwl:id "HP:0002161" ; a owl:Class ; rdfs:comment "Normal blood lysine levels are around 180-200 micromole per liter." ; rdfs:label "Hyperlysinemia" ; rdfs:subClassOf obo:HP_0010908 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002162 obo:IAO_0000115 "Hair on the neck extends more inferiorly than usual." ; oboInOwl:hasDbXref "UMLS:C1855728" ; oboInOwl:hasExactSynonym "Low hairline at back of neck", "Low posterior hair line" ; oboInOwl:id "HP:0002162" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature is often seen in later childhood, as the neck lengthens, in an individual who was born with redundant nuchal skin, which should be assessed and coded separately." ; rdfs:label "Low posterior hairline" ; rdfs:subClassOf obo:HP_0025668, obo:HP_0030141 . obo:HP_0002164 obo:IAO_0000115 "The presence of developmental dysplasia of the nail." ; oboInOwl:hasAlternativeId "HP:0001793", "HP:0001794", "HP:0001797", "HP:0008387", "HP:0008403", "HP:0008409", "HP:0008412" ; oboInOwl:hasDbXref "UMLS:C1834405" ; oboInOwl:hasExactSynonym "Atypical nail growth", "Dysplastic nails", "Onychodysplasia" ; oboInOwl:id "HP:0002164" ; a owl:Class ; rdfs:label "Nail dysplasia" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002165 obo:IAO_0000115 "Inward advance of skin over the nail plate." ; oboInOwl:hasDbXref "SNOMEDCT_US:110987009", "UMLS:C0406438" ; oboInOwl:hasExactSynonym "Nail pterygium" ; oboInOwl:id "HP:0002165" ; a owl:Class ; rdfs:label "Pterygium of nails" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0002166 obo:IAO_0000115 "A decrease in the ability to perceive vibration in the legs." ; oboInOwl:hasDbXref "UMLS:C1849134" ; oboInOwl:hasExactSynonym "Decreased lower limb vibratory sense", "Decreased vibratory sense in lower limbs", "Decreased vibratory sense in the lower extremities", "Decreased vibratory sense in the lower limbs", "Diminished vibratory sensation in the legs", "Distal sensory loss, especially vibratory sense", "Distal vibratory impairment of the lower limbs", "Impaired vibration sensation in the lower limbs" ; oboInOwl:id "HP:0002166" ; a owl:Class ; rdfs:label "Impaired vibration sensation in the lower limbs" ; rdfs:subClassOf obo:HP_0002495 . obo:HP_0002167 obo:IAO_0000115 "Abnormalities in the sound of a person's speech or vocalization not necessarily associated with a known physical cause or due to stuttering or stammering." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "MSH:D013064", "UMLS:C0037822" ; oboInOwl:hasExactSynonym "Abnormal speech", "Abnormal vocalisation", "Abnormal vocalization" ; oboInOwl:id "HP:0002167" ; a owl:Class ; rdfs:label "Abnormality of speech or vocalization" ; rdfs:subClassOf obo:HP_0011446 . obo:HP_0002168 obo:IAO_0000115 "An abnormal pattern of speech in which the words are as if measured or scanned; there is a pause after every syllable, and the syllables themselves are pronounced slowly." ; oboInOwl:hasDbXref "SNOMEDCT_US:102935005", "SNOMEDCT_US:77420001", "UMLS:C0278184", "UMLS:C0522198" ; oboInOwl:hasExactSynonym "Explosive speech" ; oboInOwl:id "HP:0002168" ; a owl:Class ; rdfs:label "Scanning speech" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002169 obo:IAO_0000115 "A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch." ; oboInOwl:hasDbXref "SNOMEDCT_US:36649002", "UMLS:C0009024" ; oboInOwl:hasExactSynonym "Involuntary rhythmic muscular contractions and relaxations" ; oboInOwl:id "HP:0002169" ; a owl:Class ; rdfs:comment "Clonus is a manifestation of spasticity that can occur with lesions of the corticospinal tract. Only sustained clonus (5 beats or more) is considered abnormal." ; rdfs:label "Clonus" ; rdfs:subClassOf obo:HP_0001347, obo:HP_0004305, obo:HP_0011442 . obo:HP_0002170 obo:IAO_0000115 "Hemorrhage occurring within the skull." ; oboInOwl:hasDbXref "MSH:D020300", "SNOMEDCT_US:1386000", "UMLS:C0151699" ; oboInOwl:hasExactSynonym "Bleeding within the skull", "Intracranial haemorrhage" ; oboInOwl:id "HP:0002170" ; a owl:Class ; rdfs:label "Intracranial hemorrhage" ; rdfs:subClassOf obo:HP_0011029, obo:HP_0100659 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002171 obo:IAO_0000115 "Gliosis is the focal proliferation of glial cells in the central nervous system." ; oboInOwl:hasDbXref "MSH:D005911", "SNOMEDCT_US:359580009", "SNOMEDCT_US:81415000", "UMLS:C0017639" ; oboInOwl:hasExactSynonym "Cerebral gliosis", "Excess astrocytes in brain" ; oboInOwl:id "HP:0002171" ; a owl:Class ; rdfs:comment "Gliosis generally occurs as a response to tissue damage. Gliosis appears bright on T2 scans upon magnetic resonance imaging, unlike encephalomalacia which follows CSF signal on all sequences. Glial cells, the non-neuronal component of the central nervous system, are divided into microglia and macroglia. The latter are in turn divided into astrocytes, oligodendrocytes, and ependymal cells. The astrocytes and the microglia are the glial cells predominantly responsible for tissue response to injury." ; rdfs:label "Gliosis" ; rdfs:subClassOf obo:HP_0100705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042065 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002172 obo:IAO_0000115 "A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps." ; oboInOwl:hasDbXref "UMLS:C1843921" ; oboInOwl:hasExactSynonym "Balance impairment" ; oboInOwl:hasRelatedSynonym "Abnormal retropulsion test", "Imbalance" ; oboInOwl:id "HP:0002172" ; a owl:Class ; rdfs:label "Postural instability" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0002173 oboInOwl:hasDbXref "UMLS:C0877056" ; oboInOwl:id "HP:0002173" ; a owl:Class ; rdfs:label "Hypoglycemic seizures" ; rdfs:subClassOf obo:HP_0001943, obo:HP_0011145 . obo:HP_0002174 obo:IAO_0000115 "A type of tremors that is triggered by holding a limb in a fixed position." ; oboInOwl:hasAlternativeId "HP:0006925", "HP:0007197" ; oboInOwl:hasDbXref "MSH:D014202", "SNOMEDCT_US:56610005", "UMLS:C0234378" ; oboInOwl:hasRelatedSynonym "Tremor, postural" ; oboInOwl:id "HP:0002174" ; a owl:Class ; rdfs:label "Postural tremor" ; rdfs:subClassOf obo:HP_0002345 . obo:HP_0002176 obo:IAO_0000115 "External mechanical compression of the spinal cord." ; oboInOwl:hasDbXref "MSH:D013117", "SNOMEDCT_US:71286001", "UMLS:C0037926" ; oboInOwl:hasExactSynonym "Pressure on spinal cord" ; oboInOwl:id "HP:0002176" ; a owl:Class ; rdfs:comment """Clinical abnormalities vary according to the site of the compression any may comprise pain, weakness, sensory loss, incontinence, and impotence. The compression may be caused by fractures of the spine, neoplasms, abscesses, and other factors.""" ; rdfs:label "Spinal cord compression" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0002179 oboInOwl:hasDbXref "SNOMEDCT_US:8652009", "UMLS:C0151818" ; oboInOwl:hasExactSynonym "Opisthotonos" ; oboInOwl:id "HP:0002179" ; a owl:Class ; rdfs:comment "Severe hyperextension and spasticity in which an individual's head, neck and spinal column arch posteriorly." ; rdfs:label "Opisthotonus" ; rdfs:subClassOf obo:HP_0001257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002180 obo:IAO_0000115 "Progressive loss of neural cells and tissue." ; oboInOwl:hasDbXref "MSH:D009410", "MSH:D019636", "UMLS:C0027746", "UMLS:C0524851", "UMLS:C4020854" ; oboInOwl:hasExactSynonym "Ongoing loss of nerve cells" ; oboInOwl:hasRelatedSynonym "Neuro-degenerative disease", "Neurodegenerative disease", "Progressive neurodegenerative disorder" ; oboInOwl:id "HP:0002180" ; a owl:Class ; rdfs:label "Neurodegeneration" ; rdfs:subClassOf obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002181 obo:IAO_0000115 "Abnormal accumulation of fluid in the brain." ; oboInOwl:hasBroadSynonym "Brain swelling" ; oboInOwl:hasDbXref "MSH:D001929", "SNOMEDCT_US:2032001", "UMLS:C0006114", "UMLS:C1527311" ; oboInOwl:hasExactSynonym "Brain edema", "Brain oedema", "Cerebral oedema", "Swelling of brain" ; oboInOwl:id "HP:0002181" ; a owl:Class ; rdfs:comment "Cerebral edema refers to swelling within brain tissue due to the accumulation of fluid, and can occur as in response to almost any insulting agent. Edema canbe observed in and around regions of dead or dying brain, around metastases and abscesses, after traumatic injury, following hypoxic ischemic injury, and around primary brain tumors. There are at least five different types of edema: vasogenic, cytotoxic, hydrostatic, interstitial, and hypoosmotic. Three effects of edema are visible on imaging: (i) loss of gray-white matter differentiation; (ii) swelling of sulci (shrinking of gyri); and (iii) mass effects. On CT scanning, extensive low density may represent vasogenic edema. As the brain swells, not only do the sulci decrease, but all of the CSF spaces of the hemispheres (including the ventricles) decrease as well. Magnetic resonance tomography may show abnormalities of diffusion-weighted imaging (DWI), and Fluid attenuation inversion recovery (FLAIR) sequences. Phenotype terms involving cerebral edema thus reflect inference about the underlying processes responsible for these abnormalities on brain imaging." ; rdfs:label "Cerebral edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002183 obo:IAO_0000115 "An abnormally heightened sensitivity to loud sounds." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "MSH:D012001", "SNOMEDCT_US:313387002", "UMLS:C0751466" ; oboInOwl:hasExactSynonym "Fear of loud sounds" ; oboInOwl:id "HP:0002183" ; a owl:Class ; rdfs:comment "Hyperacusis refers to a general hypersensitivity to sound of any frequency, and phonophobia to an anxious sensitivity towards specific sound largely independent of its volume. Hyperacusis and phonophobia represent disturbances of central auditory processing without peripheral pathology, often combined with psychosomatic reactions. Phonophobia is generally used to refer to discomfort caused by loud sounds rather than 'fear' of sounds as the etymology of the word might suggest." ; rdfs:label "Phonophobia" ; rdfs:subClassOf obo:HP_5200060 . obo:HP_0002185 obo:IAO_0000115 "Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form." ; oboInOwl:hasAlternativeId "HP:0003132", "HP:0007070" ; oboInOwl:hasDbXref "MSH:D016874", "SNOMEDCT_US:85775002", "UMLS:C0085400" ; oboInOwl:hasExactSynonym "Neurofibrillary tangles composed of disordered microtubules in neurons", "Paired helical filaments" ; oboInOwl:id "HP:0002185" ; a owl:Class ; rdfs:label "Neurofibrillary tangles" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0002186 obo:IAO_0000115 "A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." ; oboInOwl:hasDbXref "MSH:D001072", "SNOMEDCT_US:68345001", "SNOMEDCT_US:6950007", "UMLS:C0003635" ; oboInOwl:hasRelatedSynonym "Apraxias" ; oboInOwl:id "HP:0002186" ; a owl:Class ; rdfs:label "Apraxia" ; rdfs:subClassOf obo:HP_0011442, obo:HP_0011446 . obo:HP_0002187 obo:IAO_0000115 "Profound mental retardation is defined as an intelligence quotient (IQ) below 20." ; oboInOwl:hasDbXref "MSH:D008607", "SNOMEDCT_US:31216003", "UMLS:C0020796", "UMLS:C3161330" ; oboInOwl:hasExactSynonym "IQ less than 20", "Mental retardation, profound", "Profound mental retardation" ; oboInOwl:id "HP:0002187" ; a owl:Class ; rdfs:comment "Persons with profound mental retardation generally require constant care." ; rdfs:label "Intellectual disability, profound" ; rdfs:subClassOf obo:HP_0001249 . obo:HP_0002188 obo:IAO_0000115 "Delayed myelination in the central nervous system." ; oboInOwl:hasAlternativeId "HP:0005770", "HP:0006974", "HP:0007300" ; oboInOwl:hasDbXref "UMLS:C4021758" ; oboInOwl:hasExactSynonym "Delay in central nervous system myelination" ; oboInOwl:id "HP:0002188" ; a owl:Class ; rdfs:comment "A delay in the process of myelination, which normally begins in the fifth fetal month and is about 90 percent complete at the age of two years. Myelination continues into early adulthood." ; rdfs:label "Delayed CNS myelination" ; rdfs:subClassOf obo:HP_0011400, obo:HP_0012448 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0022010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002189 obo:IAO_0100001 "HP:0001262" ; oboInOwl:id "HP:0002189" ; a owl:Class ; rdfs:label "obsolete Excessive daytime sleepiness" ; owl:deprecated true . obo:HP_0002190 obo:IAO_0000115 "A cyst occurring within the choroid plexus within a cerebral ventricle." ; oboInOwl:hasDbXref "SNOMEDCT_US:230790004", "UMLS:C0338597" ; oboInOwl:id "HP:0002190" ; a owl:Class ; rdfs:comment "Choroid plexus cysts can be observed on prenatal ultrasound examinations and are associated with a weakly increased risk for fetal chromosome abnormalities such as trisomy 18." ; rdfs:label "Choroid plexus cyst" ; rdfs:subClassOf obo:HP_0007376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002191 obo:IAO_0000115 "Spasticity that increases in degree with time." ; oboInOwl:hasDbXref "UMLS:C1859520" ; oboInOwl:hasExactSynonym "Spasticity, progressive" ; oboInOwl:id "HP:0002191" ; a owl:Class ; rdfs:label "Progressive spasticity" ; rdfs:subClassOf obo:HP_0001257 . obo:HP_0002193 obo:IAO_0000115 "Individuals with Pseudobulbar signs often also demonstrate abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc." ; oboInOwl:hasDbXref "UMLS:C4025720" ; oboInOwl:hasExactSynonym "Pseudobulbar behavioural symptoms" ; oboInOwl:id "HP:0002193" ; a owl:Class ; rdfs:label "Pseudobulbar behavioral symptoms" ; rdfs:subClassOf obo:HP_0000708, obo:HP_0002200 . obo:HP_0002194 obo:IAO_0000115 "A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling." ; oboInOwl:hasAlternativeId "HP:0006905", "HP:0007046", "HP:0008973" ; oboInOwl:hasDbXref "SNOMEDCT_US:430099007", "UMLS:C1837658" ; oboInOwl:hasExactSynonym "Delayed gross motor skills", "Delayed motor skills", "Developmental delay, gross motor", "Gross motor delay", "Limited gross motor development" ; oboInOwl:id "HP:0002194" ; a owl:Class ; rdfs:label "Delayed gross motor development" ; rdfs:subClassOf obo:HP_0001270 . obo:HP_0002195 obo:IAO_0000115 "Defective development of the vermis of cerebellum." ; oboInOwl:hasDbXref "UMLS:C4025719" ; oboInOwl:id "HP:0002195" ; a owl:Class ; rdfs:comment "Note that the term cerebellar dysgenesis is generally used to refer to a morphological abnormality of the cerebellum that is of presumed developmental (rather than acquired) origin,and is often diagnosed by means of magnetic resonance tomography." ; rdfs:label "Dysgenesis of the cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002196 oboInOwl:hasDbXref "MSH:D013118", "SNOMEDCT_US:48522003", "UMLS:C0037928" ; oboInOwl:id "HP:0002196" ; a owl:Class ; rdfs:label "Myelopathy" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0034238 . obo:HP_0002197 obo:IAO_0000115 "A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex." ; oboInOwl:hasAlternativeId "HP:0002409", "HP:0007114", "HP:0007339" ; oboInOwl:hasDbXref "MSH:D012640", "SNOMEDCT_US:246545002", "UMLS:C0234533", "UMLS:C1833488" ; oboInOwl:hasExactSynonym "Generalised onset seizure", "Generalised seizures", "Generalised-onset seizure", "Generalized onset seizure", "Generalized seizures", "Generalized-onset seizures", "Primary generalised seizure", "Primary generalized seizure" ; oboInOwl:id "HP:0002197" ; a owl:Class ; rdfs:comment "in 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (over 80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination. Classifying a seizure as having apparently generalised onset does not rule out a focal-onset obscured by limitations of our current clinical methods." ; rdfs:label "Generalized-onset seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0002198 obo:IAO_0000115 "An abnormal dilatation of the fourth cerebral ventricle." ; oboInOwl:hasAlternativeId "HP:0007223" ; oboInOwl:hasDbXref "UMLS:C1847117" ; oboInOwl:hasExactSynonym "Enlarged fourth ventricle" ; oboInOwl:id "HP:0002198" ; a owl:Class ; rdfs:label "Dilated fourth ventricle" ; rdfs:subClassOf obo:HP_0002119, obo:HP_0010950 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002199 oboInOwl:hasDbXref "UMLS:C1855841" ; oboInOwl:hasExactSynonym "Low calcium seizures", "Seizures due to hypocalcemia" ; oboInOwl:id "HP:0002199" ; a owl:Class ; rdfs:label "Hypocalcemic seizures" ; rdfs:subClassOf obo:HP_0002901, obo:HP_0011145 . obo:HP_0002200 obo:IAO_0000115 "Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc." ; oboInOwl:hasDbXref "UMLS:C1838579" ; oboInOwl:hasExactSynonym "Pseudobulbar symptoms" ; oboInOwl:id "HP:0002200" ; a owl:Class ; rdfs:label "Pseudobulbar signs" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0002202 obo:IAO_0000115 "The presence of an excessive amount of fluid in the pleural cavity." ; oboInOwl:hasDbXref "MSH:D010996", "SNOMEDCT_US:60046008", "UMLS:C0032227" ; oboInOwl:hasExactSynonym "Fluid around lungs" ; oboInOwl:id "HP:0002202" ; a owl:Class ; rdfs:label "Pleural effusion" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002203 obo:IAO_0000115 "Inability to move the muscles of respiration." ; oboInOwl:hasDbXref "MSH:D012133", "SNOMEDCT_US:64228003", "UMLS:C0035232" ; oboInOwl:id "HP:0002203" ; a owl:Class ; rdfs:label "Respiratory paralysis" ; rdfs:subClassOf obo:HP_0003470, obo:HP_0004347 . obo:HP_0002204 obo:IAO_0000115 "An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery." ; oboInOwl:hasDbXref "MSH:D011655", "SNOMEDCT_US:59282003", "UMLS:C0034065" ; oboInOwl:hasExactSynonym "Blood clot in artery of lung" ; oboInOwl:id "HP:0002204" ; a owl:Class ; rdfs:label "Pulmonary embolism" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0002205 obo:IAO_0000115 "An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections." ; oboInOwl:hasAlternativeId "HP:0002782", "HP:0002873" ; oboInOwl:hasDbXref "UMLS:C3806482" ; oboInOwl:hasExactSynonym "Frequent respiratory infections", "Multiple respiratory infections", "Recurrent respiratory infections", "Susceptibility to respiratory infections", "respiratory infections, recurrent" ; oboInOwl:id "HP:0002205" ; a owl:Class ; rdfs:label "Recurrent respiratory infections" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0011947 . obo:HP_0002206 obo:IAO_0000115 "Replacement of normal lung tissues by fibroblasts and collagen." ; oboInOwl:hasAlternativeId "HP:0006523" ; oboInOwl:hasDbXref "MSH:D011658", "SNOMEDCT_US:51615001", "UMLS:C0034069" ; oboInOwl:id "HP:0002206" ; a owl:Class ; rdfs:comment "Pulmonary fibrosis leads to an irreversible impairment of alveolar oxygen transfer." ; rdfs:label "Pulmonary fibrosis" ; rdfs:subClassOf obo:HP_0006530 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002207 oboInOwl:hasDbXref "UMLS:C1843428" ; oboInOwl:id "HP:0002207" ; a owl:Class ; rdfs:label "Diffuse reticular or finely nodular infiltrations" ; rdfs:subClassOf obo:HP_0002113 . obo:HP_0002208 obo:IAO_0000115 "Hair shafts are rough in texture." ; oboInOwl:hasAlternativeId "HP:0200078" ; oboInOwl:hasBroadSynonym "Rough hair texture" ; oboInOwl:hasDbXref "SNOMEDCT_US:48610005", "UMLS:C0277959", "UMLS:C4072834" ; oboInOwl:hasExactSynonym "Coarse hair", "Coarse hair texture" ; oboInOwl:id "HP:0002208" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Coarse hair" ; rdfs:subClassOf obo:HP_0010719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000700 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002209 obo:IAO_0000115 "Decreased number of hairs per unit area of skin of the scalp." ; oboInOwl:hasAlternativeId "HP:0002233", "HP:0002556", "HP:0004526", "HP:0004534", "HP:0004541", "HP:0004542", "HP:0004772", "HP:0004774", "HP:0004775", "HP:0004782" ; oboInOwl:hasDbXref "UMLS:C1857042", "UMLS:C1873509" ; oboInOwl:hasExactSynonym "Decreased number of scalp follicles", "Hypotrichosis on scalp", "Reduced amount of scalp hair", "Reduced/lack of hair on scalp", "Reduction in the number of scalp follicles", "Scalp hypotrichosis", "Sparse scalp hair", "Thinning scalp hair" ; oboInOwl:hasRelatedSynonym "Thin scalp hair" ; oboInOwl:id "HP:0002209" ; a owl:Class ; rdfs:comment "Hypotrichosis should not be used as a synonym as, formally, it means underdevelopment of the hair. No normal values for number of hairs per unit area exist." ; rdfs:label "Sparse scalp hair" ; rdfs:subClassOf obo:HP_0008070, obo:HP_0100037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002211 obo:IAO_0000115 "A triangular depigmented region of white hairs located in the anterior midline of the scalp." ; oboInOwl:hasDbXref "SNOMEDCT_US:247564004", "UMLS:C0344312" ; oboInOwl:hasExactSynonym "Poliosis of anterior hair", "Poliosis of forelock hair", "White part of hair above forehead" ; oboInOwl:id "HP:0002211" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "White forelock" ; rdfs:subClassOf obo:HP_0011365 . obo:HP_0002212 oboInOwl:hasDbXref "SNOMEDCT_US:225570000", "UMLS:C0558165" ; oboInOwl:hasExactSynonym "Curly hair" ; oboInOwl:id "HP:0002212" ; a owl:Class ; rdfs:label "Curly hair" ; rdfs:subClassOf obo:HP_0010719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000405 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002213 obo:IAO_0000115 "Hair that is fine or thin to the touch." ; oboInOwl:hasAlternativeId "HP:0200132" ; oboInOwl:hasDbXref "SNOMEDCT_US:247546006", "UMLS:C0423867" ; oboInOwl:hasExactSynonym "Fine hair", "Fine hair shaft", "Fine hair texture", "Thin hair", "Thin hair shaft", "Thin hair texture", "Thinned hair" ; oboInOwl:id "HP:0002213" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fine hair" ; rdfs:subClassOf obo:HP_0010719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002215 obo:IAO_0000115 "Reduced number or density of axillary hair." ; oboInOwl:hasAlternativeId "HP:0004514", "HP:0004518", "HP:0004545" ; oboInOwl:hasBroadSynonym "Sparse axillary and pubic hair", "Sparse scalp, axillary, and pubic hair" ; oboInOwl:hasDbXref "UMLS:C1858574" ; oboInOwl:hasExactSynonym "Limited armpit hair", "Little underarm hair", "sparse to absent axillary hair" ; oboInOwl:id "HP:0002215" ; a owl:Class ; rdfs:label "Sparse axillary hair" ; rdfs:subClassOf obo:HP_0008070, obo:HP_0100134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013699 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002216 obo:IAO_0000115 "Development of gray hair at a younger than normal age." ; oboInOwl:hasDbXref "SNOMEDCT_US:387833009", "UMLS:C0263498" ; oboInOwl:hasExactSynonym "Early graying", "Early greying", "Premature graying", "Premature graying of hair", "Premature greying", "Premature greying of hair", "Premature hair graying", "Premature hair greying" ; oboInOwl:hasRelatedSynonym "Premature graying of the hair", "Premature greying of the hair" ; oboInOwl:id "HP:0002216" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Premature graying of hair" ; rdfs:subClassOf obo:HP_0007495, obo:HP_0009887 . obo:HP_0002217 obo:IAO_0000115 "Hair whose growth is slower than normal." ; oboInOwl:hasAlternativeId "HP:0004767", "HP:0004770", "HP:0004781" ; oboInOwl:hasDbXref "UMLS:C1832348" ; oboInOwl:hasExactSynonym "Slow growing hair", "Slow rate of hair growth", "Slow speed of hair growth", "Slow-growing hair" ; oboInOwl:id "HP:0002217" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Slow-growing hair" ; rdfs:subClassOf obo:HP_0011363 . obo:HP_0002218 obo:IAO_0000115 "Hypopigmented hair that appears silver-gray." ; oboInOwl:hasDbXref "UMLS:C1836576" ; oboInOwl:hasExactSynonym "Silver-gray hair", "Silver-gray hair color", "Silver-gray hair colour", "Silvery-gray hair" ; oboInOwl:id "HP:0002218" ; a owl:Class ; rdfs:label "Silver-gray hair" ; rdfs:subClassOf obo:HP_0011358 . obo:HP_0002219 obo:IAO_0000115 "Excessive, increased hair growth located in the facial region." ; oboInOwl:hasDbXref "MSH:C565029", "UMLS:C1851400" ; oboInOwl:hasExactSynonym "Increased facial hair growth" ; oboInOwl:id "HP:0002219" ; a owl:Class ; rdfs:label "Facial hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010171 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002220 oboInOwl:hasDbXref "UMLS:C1843390" ; oboInOwl:id "HP:0002220" ; a owl:Class ; rdfs:label "Melanin pigment aggregation in hair shafts" ; rdfs:subClassOf obo:HP_0009887 . obo:HP_0002221 obo:IAO_0000115 "Absence of axillary hair." ; oboInOwl:hasAlternativeId "HP:0004549" ; oboInOwl:hasDbXref "UMLS:C1859392" ; oboInOwl:id "HP:0002221" ; a owl:Class ; rdfs:label "Absent axillary hair" ; rdfs:subClassOf obo:HP_0002298, obo:HP_0100134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013699 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002223 obo:IAO_0000115 "Absence of the eyebrow." ; oboInOwl:hasDbXref "SNOMEDCT_US:253208007", "SNOMEDCT_US:422441003", "UMLS:C0431448", "UMLS:C0578682", "UMLS:C4280581", "UMLS:C4280582" ; oboInOwl:hasExactSynonym "Absent eyebrow", "Absent eyebrows", "Failure of development of eyebrows" ; oboInOwl:hasNarrowSynonym "Agenesis of eyebrows", "Aplasia of eyebrows", "Loss of eyebrows", "Missing eyebrows" ; oboInOwl:id "HP:0002223" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent eyebrow" ; rdfs:subClassOf obo:HP_0002298, obo:HP_0100840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002224 obo:IAO_0000115 "The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." ; oboInOwl:hasBroadSynonym "Nappy hair texture" ; oboInOwl:hasDbXref "MEDDRA:10048017", "SNOMEDCT_US:52564001", "UMLS:C0343073", "UMLS:C4072835", "UMLS:C4072836", "UMLS:C4073292" ; oboInOwl:hasExactSynonym "Kinked hair", "Wooly hair" ; oboInOwl:hasRelatedSynonym "Afro-textured hair", "Kinky hair texture" ; oboInOwl:id "HP:0002224" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "See figures in PMID:20464096." ; rdfs:label "Woolly hair" ; rdfs:subClassOf obo:HP_0010719 . obo:HP_0002225 obo:IAO_0000115 "Reduced number or density of pubic hair." ; oboInOwl:hasAlternativeId "HP:0004778" ; oboInOwl:hasDbXref "UMLS:C1858573" ; oboInOwl:hasExactSynonym "Decreased sexual hair", "Sparse pubic hair", "sparse to absent pubic hair" ; oboInOwl:id "HP:0002225" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sparse pubic hair" ; rdfs:subClassOf obo:HP_0008070, obo:HP_0100133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013698 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002226 obo:IAO_0000115 "White color (lack of pigmentation) of the eyebrow." ; oboInOwl:hasAlternativeId "HP:0002228", "HP:0004536" ; oboInOwl:hasDbXref "UMLS:C1836737", "UMLS:C4280579", "UMLS:C4280580" ; oboInOwl:hasExactSynonym "Depigmented eyebrow", "Hypopigmented eyebrow", "Pale eyebrow", "White eyebrow" ; oboInOwl:hasNarrowSynonym "Grey eyebrow" ; oboInOwl:hasRelatedSynonym "Blonde eyebrow" ; oboInOwl:id "HP:0002226" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "White eyebrow" ; rdfs:subClassOf obo:HP_0000534, obo:HP_0009887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000323 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002227 obo:IAO_0000115 "White color (lack of pigmentation) of the eyelashes." ; oboInOwl:hasDbXref "UMLS:C1836736", "UMLS:C4280578" ; oboInOwl:hasExactSynonym "Blonde eyelashes", "Depigmented eyelashes", "Pale eyelashes", "White eyelashes" ; oboInOwl:hasNarrowSynonym "Grey eyelashes" ; oboInOwl:id "HP:0002227" ; a owl:Class ; rdfs:label "White eyelashes" ; rdfs:subClassOf obo:HP_0000499, obo:HP_0009887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000323 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002229 obo:IAO_0100001 "HP:0002232" ; oboInOwl:id "HP:0002229" ; a owl:Class ; rdfs:label "obsolete Alopecia areata" ; owl:deprecated true . obo:HP_0002230 obo:IAO_0000115 "Abnormally increased hair growth over much of the entire body." ; oboInOwl:hasDbXref "UMLS:C1849211" ; oboInOwl:hasExactSynonym "Excessive hairiness over body", "Generalised hirsutism" ; oboInOwl:id "HP:0002230" ; a owl:Class ; rdfs:label "Generalized hirsutism" ; rdfs:subClassOf obo:HP_0001007 . obo:HP_0002231 obo:IAO_0000115 "Sparseness of the body hair." ; oboInOwl:hasDbXref "UMLS:C1862863" ; oboInOwl:hasExactSynonym "Limited body hair", "Little body hair", "Sparse body hair", "Sparse to absent body hair" ; oboInOwl:id "HP:0002231" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sparse body hair" ; rdfs:subClassOf obo:HP_0008070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002232 obo:IAO_0000115 "Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches." ; oboInOwl:hasAlternativeId "HP:0002229" ; oboInOwl:hasDbXref "MSH:C531609", "MSH:D000506", "SNOMEDCT_US:68225006", "UMLS:C0002171", "UMLS:C1862862" ; oboInOwl:hasExactSynonym "Alopecia areata", "Patchy baldness" ; oboInOwl:id "HP:0002232" ; a owl:Class ; rdfs:label "Patchy alopecia" ; rdfs:subClassOf obo:HP_0001596, obo:HP_0011360 . obo:HP_0002234 obo:IAO_0000115 "Loss of scalp hair at an earlier than normal age." ; oboInOwl:hasDbXref "UMLS:C4025718" ; oboInOwl:hasExactSynonym "Early balding" ; oboInOwl:id "HP:0002234" ; a owl:Class ; rdfs:label "Early balding" ; rdfs:subClassOf obo:HP_0011360 . obo:HP_0002235 obo:IAO_0000115 "A characteristic triangular, kidney- or heat-shaped diameter of hair shafts with typical longitudinal canalicular deformation as observable by scanning electron microscopy." ; oboInOwl:hasAlternativeId "HP:0002285" ; oboInOwl:hasDbXref "UMLS:C1860608" ; oboInOwl:id "HP:0002235" ; a owl:Class ; rdfs:label "Pili canaliculi" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0002236 obo:IAO_0000115 "Upward and/or sideward growth of anterior hair." ; oboInOwl:hasDbXref "UMLS:C1185616", "UMLS:C2675540", "UMLS:C3275754" ; oboInOwl:hasExactSynonym "Cowlick", "Frontal Cowlick", "Frontal upsweep of hair", "Upswept frontal hair" ; oboInOwl:hasRelatedSynonym "Upswept frontal hair pattern", "Upswept frontal hairline" ; oboInOwl:id "HP:0002236" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Frontal upsweep of hair" ; rdfs:subClassOf obo:HP_0010721 . obo:HP_0002239 obo:IAO_0000115 "Hemorrhage affecting the gastrointestinal tract." ; oboInOwl:hasDbXref "MSH:D006471", "SNOMEDCT_US:74474003", "UMLS:C0017181" ; oboInOwl:hasExactSynonym "GI haemorrhage", "GI hemorrhage", "Gastrointestinal bleeding", "Gastrointestinal haemorrhage" ; oboInOwl:id "HP:0002239" ; a owl:Class ; rdfs:label "Gastrointestinal hemorrhage" ; rdfs:subClassOf obo:HP_0011029, obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002240 obo:IAO_0000115 "Abnormally increased size of the liver." ; oboInOwl:hasAlternativeId "HP:0001393", "HP:0001398" ; oboInOwl:hasDbXref "MSH:D006529", "SNOMEDCT_US:80515008", "UMLS:C0019209" ; oboInOwl:hasExactSynonym "Enlarged liver" ; oboInOwl:id "HP:0002240" ; a owl:Class ; rdfs:label "Hepatomegaly" ; rdfs:subClassOf obo:HP_0003271, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002242 obo:IAO_0000115 "An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine." ; oboInOwl:hasAlternativeId "HP:0002628" ; oboInOwl:hasDbXref "MSH:D007410", "SNOMEDCT_US:85919009", "UMLS:C0021831" ; oboInOwl:hasExactSynonym "Abnormality of the intestine", "Enteropathy" ; oboInOwl:id "HP:0002242" ; a owl:Class ; rdfs:label "Abnormal intestine morphology" ; rdfs:subClassOf obo:HP_0012718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002243 obo:IAO_0000115 "Abnormal loss of protein from the digestive tract related to excessive leakage of plasma proteins into the lumen of the gastrointestinal tract." ; oboInOwl:hasDbXref "MSH:D011504", "SNOMEDCT_US:22542007", "SNOMEDCT_US:66972006", "UMLS:C0033680" ; oboInOwl:id "HP:0002243" ; a owl:Class ; rdfs:comment "Affected individuals may present with peripheral edema, diarrhea with or without bleeding, abdominal pain, and/or weight loss. Protein-losing enteropathy is not a disease but is a manifestation of a number of gastrointestinal diseases and can be related to factors such as lymphatic obstruction, mucosal disease with erosions, ulcerations, or increased mucosal permeability to proteins." ; rdfs:label "Protein-losing enteropathy" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0002244 obo:IAO_0000115 "A structural abnormality of the small intestine." ; oboInOwl:hasDbXref "UMLS:C4025717" ; oboInOwl:hasExactSynonym "Abnormality of the small intestine" ; oboInOwl:id "HP:0002244" ; a owl:Class ; rdfs:label "Abnormal small intestine morphology" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002108 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002245 obo:IAO_0000115 "Meckel's diverticulum is a congenital diverticulum located in the distal ileum." ; oboInOwl:hasDbXref "MEDDRA:10027055", "MSH:D008467", "SNOMEDCT_US:127962001", "SNOMEDCT_US:37373007", "UMLS:C0025037" ; oboInOwl:id "HP:0002245" ; a owl:Class ; rdfs:label "Meckel diverticulum" ; rdfs:subClassOf obo:HP_0001549 . obo:HP_0002246 obo:IAO_0000115 "An abnormality of the duodenum, i.e., the first section of the small intestine." ; oboInOwl:hasDbXref "UMLS:C4025716" ; oboInOwl:hasExactSynonym "Abnormality of the duodenum" ; oboInOwl:id "HP:0002246" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal duodenum morphology" ; rdfs:subClassOf obo:HP_0002244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002247 obo:IAO_0000115 "A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum." ; oboInOwl:hasDbXref "Fyler:4406", "MEDDRA:10013812", "MSH:C535720", "SNOMEDCT_US:51118003", "UMLS:C0266174" ; oboInOwl:hasExactSynonym "Absence or narrowing of first part of small bowel" ; oboInOwl:id "HP:0002247" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Duodenal atresia" ; rdfs:subClassOf obo:HP_0002246, obo:HP_0011100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002248 obo:IAO_0000115 "The vomiting of blood." ; oboInOwl:hasDbXref "MSH:D006396", "SNOMEDCT_US:8765009", "UMLS:C0018926" ; oboInOwl:hasExactSynonym "Vomitting blood" ; oboInOwl:id "HP:0002248" ; a owl:Class ; rdfs:comment "The source of hematemesis is generally the upper gastrointestinal tract." ; rdfs:label "Hematemesis" ; rdfs:subClassOf obo:HP_0002239 . obo:HP_0002249 obo:IAO_0000115 "The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding." ; oboInOwl:hasDbXref "MSH:D008551", "SNOMEDCT_US:249627005", "SNOMEDCT_US:267055007", "SNOMEDCT_US:269899009", "SNOMEDCT_US:2901004", "SNOMEDCT_US:35064005", "UMLS:C0025222", "UMLS:C0474585" ; oboInOwl:hasNarrowSynonym "Black faeces", "Black feces" ; oboInOwl:id "HP:0002249" ; a owl:Class ; rdfs:label "Melena" ; rdfs:subClassOf obo:HP_0002239, obo:HP_0025085 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001988 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002250 obo:IAO_0000115 "Any abnormality of the large intestine." ; oboInOwl:hasDbXref "UMLS:C4025715" ; oboInOwl:hasExactSynonym "Abnormality of the large intestine" ; oboInOwl:id "HP:0002250" ; a owl:Class ; rdfs:comment "The large intestine comprises the cecum and colon." ; rdfs:label "Abnormal large intestine morphology" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002251 obo:IAO_0000115 "An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon." ; oboInOwl:hasAlternativeId "HP:0002029", "HP:0002030", "HP:0002606", "HP:0004391" ; oboInOwl:hasDbXref "MEDDRA:10027110", "MSH:D006627", "MSH:D008531", "SNOMEDCT_US:204739008", "SNOMEDCT_US:33995003", "SNOMEDCT_US:367495003", "UMLS:C0019569", "UMLS:C0025160" ; oboInOwl:hasExactSynonym "Congenital megacolon", "Enlarged colon lacking nerve cells", "Hirschsprung megacolon", "Megacolon" ; oboInOwl:hasRelatedSynonym "Hirschsprung disease" ; oboInOwl:id "HP:0002251" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Aganglionic megacolon is characterized by congenital absence of intrinsic ganglion cells in the myenteric (Auerbach) and submucosal (Meissner) plexuses of the gastrointestinal tract." ; rdfs:label "Aganglionic megacolon" ; rdfs:subClassOf obo:HP_0004362 . obo:HP_0002253 obo:IAO_0000115 "The presence of multiple diverticula of the colon." ; oboInOwl:hasAlternativeId "HP:0005860" ; oboInOwl:hasDbXref "MEDDRA:10009993", "MSH:D004241", "MSH:D043963", "SNOMEDCT_US:398050005", "UMLS:C0012811", "UMLS:C0012819" ; oboInOwl:hasExactSynonym "Colonic diverticulosis" ; oboInOwl:hasRelatedSynonym "Colon diverticula" ; oboInOwl:id "HP:0002253" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Colonic diverticula" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0005222 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_68 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002254 obo:IAO_0000115 "Repeated episodes of diarrhea separated by periods without diarrhea." ; oboInOwl:hasDbXref "UMLS:C0239181" ; oboInOwl:hasExactSynonym "Episodic diarrhea", "Episodic diarrhoea", "Intermittent diarrhoea" ; oboInOwl:id "HP:0002254" ; a owl:Class ; rdfs:label "Intermittent diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0002256 oboInOwl:hasDbXref "MEDDRA:10013533", "SNOMEDCT_US:8114009", "UMLS:C0267498" ; oboInOwl:id "HP:0002256" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Small bowel diverticula" ; rdfs:subClassOf obo:HP_0002244, obo:HP_0005222 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_68 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002257 obo:IAO_0000115 "Chronic inflammation of the nasal mucosa." ; oboInOwl:hasDbXref "SNOMEDCT_US:86094006", "UMLS:C0008711" ; oboInOwl:id "HP:0002257" ; a owl:Class ; rdfs:label "Chronic rhinitis" ; rdfs:subClassOf obo:HP_0012384 . obo:HP_0002263 obo:IAO_0000115 "More pronounced paramedian peaks and median notch of the Cupid's bow." ; oboInOwl:hasDbXref "UMLS:C1850629" ; oboInOwl:hasExactSynonym "Cupid bow upper lip", "Cupid's bow, accentuated", "Cupid-bow shaped upper lip", "Exaggerated cupid's bow", "Prominent cupid-bow of upper lip" ; oboInOwl:id "HP:0002263" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This may be associated with a Deep philtrum, but that finding should be coded separately." ; rdfs:label "Exaggerated cupid's bow" ; rdfs:subClassOf obo:HP_0011339 . obo:HP_0002265 oboInOwl:hasDbXref "UMLS:C3808403" ; oboInOwl:hasExactSynonym "Large fleshy ears" ; oboInOwl:id "HP:0002265" ; a owl:Class ; rdfs:label "Large fleshy ears" ; rdfs:subClassOf obo:HP_0000400 . obo:HP_0002266 obo:IAO_0000115 "A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive." ; oboInOwl:hasDbXref "MSH:D020938", "UMLS:C0752323" ; oboInOwl:hasExactSynonym "Focal clonic seizures", "Localised clonic seizure", "Localized clonic seizure", "Partial clonic seizure", "Segmental clonic seizure" ; oboInOwl:id "HP:0002266" ; a owl:Class ; rdfs:comment "The movement involves sustained rhythmic jerking, this may involve a limb, half the face or one side of the body, and may spread according to a Jacksonian march: The jerking may spread to involve parts of the body according to their representation on the motor cortex (according to the homunculus)." ; rdfs:label "Focal clonic seizure" ; rdfs:subClassOf obo:HP_0011153, obo:HP_0020221 . obo:HP_0002267 obo:IAO_0000115 "An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face." ; oboInOwl:hasDbXref "MSH:D000071017", "SNOMEDCT_US:19557000", "UMLS:C0234166", "UMLS:C1740801", "UMLS:C1836014", "UMLS:C1848918" ; oboInOwl:hasExactSynonym "Exaggerated acoustic startle response", "Increased startle response" ; oboInOwl:hasRelatedSynonym "Hyperekplexia" ; oboInOwl:id "HP:0002267" ; a owl:Class ; rdfs:label "Exaggerated startle response" ; rdfs:subClassOf obo:HP_0002071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002268 obo:IAO_0000115 "A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes." ; oboInOwl:hasAlternativeId "HP:0002412" ; oboInOwl:hasDbXref "MSH:D004421", "SNOMEDCT_US:230310003", "UMLS:C0393588" ; oboInOwl:hasExactSynonym "Episodic dystonia" ; oboInOwl:id "HP:0002268" ; a owl:Class ; rdfs:label "Paroxysmal dystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0002269 obo:IAO_0000115 "An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain." ; oboInOwl:hasAlternativeId "HP:0007317" ; oboInOwl:hasDbXref "MSH:D054081", "UMLS:C1837249" ; oboInOwl:hasExactSynonym "Abnormal neuronal migration", "Heterotopias/abnormal migration", "Migrational brain disorder", "Neuronal migration disorder" ; oboInOwl:id "HP:0002269" ; a owl:Class ; rdfs:label "Abnormality of neuronal migration" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001764 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002270 obo:IAO_0000115 "An abnormality of the autonomic nervous system." ; oboInOwl:hasDbXref "UMLS:C4025714" ; oboInOwl:id "HP:0002270" ; a owl:Class ; rdfs:comment "The autonomic nervous system is the part of the peripheral nervous system that controls visceral functions such as heart rate and digestion and functions largely below the level of consciousness." ; rdfs:label "Abnormality of the autonomic nervous system" ; rdfs:subClassOf obo:HP_0410008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002410 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002271 obo:IAO_0100001 "HP:0012332" ; oboInOwl:id "HP:0002271" ; a owl:Class ; rdfs:label "obsolete Autonomic dysregulation" ; owl:deprecated true . obo:HP_0002273 obo:IAO_0000115 "Weakness of all four limbs." ; oboInOwl:hasAlternativeId "HP:0002338" ; oboInOwl:hasDbXref "MSH:D011782", "SNOMEDCT_US:91327001", "UMLS:C0270790" ; oboInOwl:hasExactSynonym "Quadriparesis" ; oboInOwl:id "HP:0002273" ; a owl:Class ; rdfs:comment "Tetraplegia refers to a complete loss of strength, whereas Tetraparesis refers to an incomplete loss of strength." ; rdfs:label "Tetraparesis" ; rdfs:subClassOf obo:HP_0030182 . obo:HP_0002275 oboInOwl:hasDbXref "UMLS:C1848453" ; oboInOwl:hasExactSynonym "Poor motor coordination" ; oboInOwl:id "HP:0002275" ; a owl:Class ; rdfs:label "Poor motor coordination" ; rdfs:subClassOf obo:HP_0011443 . obo:HP_0002277 obo:IAO_0000115 "An abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection." ; oboInOwl:hasAlternativeId "HP:0000596" ; oboInOwl:hasDbXref "MSH:D006732", "SNOMEDCT_US:12731000", "SNOMEDCT_US:192915005", "SNOMEDCT_US:271730003", "UMLS:C0019937" ; oboInOwl:hasExactSynonym "Horner's syndrome", "Oculosympathetic palsy" ; oboInOwl:id "HP:0002277" ; a owl:Class ; rdfs:comment "Ptosis, miosis, and occasionally apparent enophthalmos and anhidrosis on one side of the face, loss of ciliospinal reflex and blood shot conjunctiva." ; rdfs:label "Horner syndrome" ; rdfs:subClassOf obo:HP_0000508, obo:HP_0000616, obo:HP_0012332 . obo:HP_0002280 obo:IAO_0000115 "Increase in size of the cisterna magna, one of three principal openings in the subarachnoid space between the arachnoid and pia mater, located between the cerebellum and the dorsal surface of the medulla oblongata." ; oboInOwl:hasDbXref "UMLS:C1853377" ; oboInOwl:hasExactSynonym "Large cisterna magna" ; oboInOwl:hasRelatedSynonym "Mega cisterna magna" ; oboInOwl:id "HP:0002280" ; a owl:Class ; rdfs:comment "Cerebrospinal fluid produced in the fourth ventricle drains into the cisterna magna via the lateral apertures and median aperture." ; rdfs:label "Enlarged cisterna magna" ; rdfs:subClassOf obo:HP_0005445 . obo:HP_0002281 obo:IAO_0100001 "HP:0002282" ; oboInOwl:id "HP:0002281" ; a owl:Class ; rdfs:label "obsolete Gray matter heterotopias" ; owl:deprecated true . obo:HP_0002282 obo:IAO_0000115 "Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter." ; oboInOwl:hasAlternativeId "HP:0002281", "HP:0007314" ; oboInOwl:hasDbXref "MSH:D002828", "SNOMEDCT_US:128490007", "SNOMEDCT_US:416286003", "SNOMEDCT_US:417338002", "UMLS:C0008519" ; oboInOwl:hasExactSynonym "Gray matter heterotopias", "Grey matter heterotopia", "Grey matter heterotopias", "Heterotopia", "Heterotopias", "Neuronal heterotopia" ; oboInOwl:id "HP:0002282" ; a owl:Class ; rdfs:comment "Gray matter heterotopia is caused by clumps of grey matter being located in the wrong part of the brain. It is characterized as a type of cortical malformation. The neurons in heterotopia may appear to be normal, except for their mislocation; nuclear studies have shown glucose metabolism equal to that of normally positioned gray matter. The condition causes a variety of symptoms, but usually includes some degree of epilepsy or recurring seizures, and often affects the brain's ability to function on higher levels. Symptoms range from nonexistent to profound, in which case heterotopia can result in severe seizure disorder, loss of motor skills, and mental retardation. Neuronal heterotopia consists of grey matter within the white matter, and the term grey matter heterotopia is more frequently used." ; rdfs:label "Gray matter heterotopia" ; rdfs:subClassOf obo:HP_0002269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0002319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002283 obo:IAO_0000115 "Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size." ; oboInOwl:hasAlternativeId "HP:0002369", "HP:0002462" ; oboInOwl:hasDbXref "UMLS:C0241816" ; oboInOwl:hasExactSynonym "Diffuse brain atrophy", "Generalised brain atrophy", "Generalised brain degeneration", "Generalised cerebral atrophy", "Generalized brain atrophy", "Generalized brain degeneration", "Generalized cerebral atrophy" ; oboInOwl:id "HP:0002283" ; a owl:Class ; rdfs:comment "Global brain atrophy can be visualized and quantified by magnetic resonance imaging." ; rdfs:label "Global brain atrophy" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0012444 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0002506 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0100275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002286 obo:IAO_0000115 "A lesser degree of hair pigmentation than would otherwise be expected." ; oboInOwl:hasAlternativeId "HP:0002214", "HP:0002294" ; oboInOwl:hasDbXref "SNOMEDCT_US:297995004", "UMLS:C0239801", "UMLS:C1849221" ; oboInOwl:hasExactSynonym "Blond hair", "Fair hair", "Fair hair color", "Fair hair colour", "Flaxen hair color", "Flaxen hair colour", "Light colored hair", "Light coloured hair", "Sandy hair color", "Sandy hair colour", "Straw colored hair", "Straw coloured hair", "Towhead (hair color)" ; oboInOwl:id "HP:0002286" ; a owl:Class ; rdfs:comment "For instance, in Angelman syndrome, reduced expression of the gene OCA2 is associated with light-colored hair and fair skin, such that affected children often have noticeably fairer hair than their unaffected relatives." ; rdfs:label "Fair hair" ; rdfs:subClassOf obo:HP_0011358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000665 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002287 obo:IAO_0000115 "Progressive loss of hair." ; oboInOwl:hasDbXref "UMLS:C1851885" ; oboInOwl:id "HP:0002287" ; a owl:Class ; rdfs:label "Progressive alopecia" ; rdfs:subClassOf obo:HP_0001596 . obo:HP_0002289 obo:IAO_0000115 "Loss of all hair on the entire body." ; oboInOwl:hasAlternativeId "HP:0004550" ; oboInOwl:hasDbXref "MSH:C537055", "SNOMEDCT_US:86166000", "UMLS:C0263505" ; oboInOwl:hasExactSynonym "Alopecia, complete" ; oboInOwl:hasRelatedSynonym "Universal alopecia" ; oboInOwl:id "HP:0002289" ; a owl:Class ; rdfs:label "Alopecia universalis" ; rdfs:subClassOf obo:HP_0001596 . obo:HP_0002290 obo:IAO_0000115 "Circumscribed depigmentation of the hair of the head or the eyelashes." ; oboInOwl:hasDbXref "SNOMEDCT_US:14240001", "UMLS:C0221262" ; oboInOwl:hasExactSynonym "Patch of white hair", "White patch" ; oboInOwl:id "HP:0002290" ; a owl:Class ; rdfs:label "Poliosis" ; rdfs:subClassOf obo:HP_0011365 . obo:HP_0002292 obo:IAO_0000115 "Absence of hair in the anterior midline and/or parietal areas." ; oboInOwl:hasBroadSynonym "Male pattern baldness" ; oboInOwl:hasDbXref "MSH:D000505", "SNOMEDCT_US:87872006", "UMLS:C1864584", "UMLS:C4083212" ; oboInOwl:hasExactSynonym "Frontal balding" ; oboInOwl:id "HP:0002292" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Frontal balding" ; rdfs:subClassOf obo:HP_0011360 . obo:HP_0002293 oboInOwl:hasAlternativeId "HP:0200115" ; oboInOwl:hasBroadSynonym "Absence of scalp hair", "Baldness", "Missing scalp hair" ; oboInOwl:hasDbXref "MSH:D000505", "SNOMEDCT_US:278040002", "SNOMEDCT_US:298000004", "SNOMEDCT_US:56317004", "UMLS:C0002170", "UMLS:C0574769", "UMLS:C1850535" ; oboInOwl:hasExactSynonym "Pathologic hair loss from scalp", "Scalp hair loss" ; oboInOwl:id "HP:0002293" ; a owl:Class ; rdfs:label "Alopecia of scalp" ; rdfs:subClassOf obo:HP_0001596, obo:HP_0100037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002296 obo:IAO_0000115 "Progressively reduced or lacking hair growth." ; oboInOwl:hasDbXref "UMLS:C1857048" ; oboInOwl:id "HP:0002296" ; a owl:Class ; rdfs:label "Progressive hypotrichosis" ; rdfs:subClassOf obo:HP_0008070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0002297 oboInOwl:hasBroadSynonym "Ginger hair color", "Ginger hair colour" ; oboInOwl:hasDbXref "SNOMEDCT_US:297997007", "UMLS:C0239803" ; oboInOwl:hasExactSynonym "Red hair", "Red hair color", "Red hair colour", "Red head (hair color)" ; oboInOwl:id "HP:0002297" ; a owl:Class ; rdfs:label "Red hair" ; rdfs:subClassOf obo:HP_0009887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002298 oboInOwl:hasAlternativeId "HP:0004548" ; oboInOwl:hasDbXref "SNOMEDCT_US:297991008", "UMLS:C0574763" ; oboInOwl:hasExactSynonym "Absent hair" ; oboInOwl:id "HP:0002298" ; a owl:Class ; rdfs:label "Absent hair" ; rdfs:subClassOf obo:HP_0011362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002299 obo:IAO_0000115 "Fragile, easily breakable hair, i.e., with reduced tensile strength." ; oboInOwl:hasBroadSynonym "Easily breakable hair", "Fractured hair", "Fragile hair", "Reduced tensile strength of hair" ; oboInOwl:hasDbXref "SNOMEDCT_US:25159003", "UMLS:C0263490", "UMLS:C1851868", "UMLS:C1970705", "UMLS:C4072837" ; oboInOwl:hasExactSynonym "Brittle hair" ; oboInOwl:id "HP:0002299" ; a owl:Class ; rdfs:comment "Brittle is used to describe hair which is very short because of an abnormality is in the structure of the shaft. Microscopically the ends appear fractured. Affected patients may report bits of hair on the collar or pillow. Brittle hair can be distinguished from hypotrichosis due to slow or deficient growth (e.g., due to hypotrichosis simplex) and hypotrichosis due to the hair being fine and soft where the hair just wears out too quickly (e.g., due to ectodermal dysplasia)." ; rdfs:label "Brittle hair" ; rdfs:subClassOf obo:HP_0010719 . obo:HP_0002300 oboInOwl:hasDbXref "MSH:D009155", "SNOMEDCT_US:88052002", "UMLS:C0026884" ; oboInOwl:hasExactSynonym "Inability to speak", "Muteness" ; oboInOwl:id "HP:0002300" ; a owl:Class ; rdfs:label "Mutism" ; rdfs:subClassOf obo:HP_0000708, obo:HP_0002167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000621 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002301 obo:IAO_0000115 "Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body." ; oboInOwl:hasDbXref "MSH:D006429", "SNOMEDCT_US:50582007", "UMLS:C0018991" ; oboInOwl:hasExactSynonym "Paralysis on one side of body" ; oboInOwl:id "HP:0002301" ; a owl:Class ; rdfs:label "Hemiplegia" ; rdfs:subClassOf obo:HP_0004374 . obo:HP_0002304 obo:IAO_0000115 "Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily." ; oboInOwl:hasDbXref "SNOMEDCT_US:33994004", "UMLS:C0085623" ; oboInOwl:id "HP:0002304" ; a owl:Class ; rdfs:comment "Akinesia is a typical extrapyramidal abnormality." ; rdfs:label "Akinesia" ; rdfs:subClassOf obo:HP_0002374 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050881 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002305 obo:IAO_0000115 "A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest." ; oboInOwl:hasAlternativeId "HP:0007167", "HP:0007316" ; oboInOwl:hasDbXref "MSH:D001264", "SNOMEDCT_US:44913001", "SNOMEDCT_US:58593005", "UMLS:C0004158", "UMLS:C1845265" ; oboInOwl:hasExactSynonym "Athetoid movements", "Involuntary writhing movements", "Involuntary writhing movements in fingers, hands, toes, and feet" ; oboInOwl:id "HP:0002305" ; a owl:Class ; rdfs:comment "Athetosis derives from the Greek word for 'changeable' or 'unfixed'." ; rdfs:label "Athetosis" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 . obo:HP_0002307 obo:IAO_0000115 "Habitual flow of saliva out of the mouth." ; oboInOwl:hasDbXref "MSH:D012798", "SNOMEDCT_US:275295002", "SNOMEDCT_US:53827007", "SNOMEDCT_US:62718007", "UMLS:C0013132", "UMLS:C0037036" ; oboInOwl:hasExactSynonym "Dribbling", "Drooling", "Sialorrhea" ; oboInOwl:id "HP:0002307" ; a owl:Class ; rdfs:label "Drooling" ; rdfs:subClassOf obo:HP_0000708, obo:HP_0003781 . obo:HP_0002308 obo:IAO_0000115 "Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow." ; oboInOwl:hasDbXref "MSH:D001139", "SNOMEDCT_US:253184003", "UMLS:C0003803" ; oboInOwl:hasExactSynonym "Arnold-Chiari malformation" ; oboInOwl:id "HP:0002308" ; a owl:Class ; rdfs:label "Chiari malformation" ; rdfs:subClassOf obo:HP_0002438 . obo:HP_0002310 oboInOwl:hasDbXref "MSH:D020820", "SNOMEDCT_US:49386006", "UMLS:C0152115" ; oboInOwl:hasExactSynonym "Orofacial dyskinesias" ; oboInOwl:id "HP:0002310" ; a owl:Class ; rdfs:label "Orofacial dyskinesia" ; rdfs:subClassOf obo:HP_0100660 . obo:HP_0002311 oboInOwl:hasAlternativeId "HP:0002276" ; oboInOwl:hasDbXref "MSH:D001259", "SNOMEDCT_US:281016006", "SNOMEDCT_US:302289002", "UMLS:C0520966" ; oboInOwl:hasExactSynonym "Difficulties in coordination", "Incoordination", "Incoordination of limb movements", "Limb incoordination" ; oboInOwl:id "HP:0002311" ; a owl:Class ; rdfs:label "Incoordination" ; rdfs:subClassOf obo:HP_0011443 . obo:HP_0002312 obo:IAO_0000115 "Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects." ; oboInOwl:hasDbXref "SNOMEDCT_US:7006003", "UMLS:C0233844" ; oboInOwl:hasExactSynonym "Clumsiness" ; oboInOwl:id "HP:0002312" ; a owl:Class ; rdfs:label "Clumsiness" ; rdfs:subClassOf obo:HP_0002311 . obo:HP_0002313 oboInOwl:hasAlternativeId "HP:0007191" ; oboInOwl:hasDbXref "MSH:D020336", "SNOMEDCT_US:312444006", "UMLS:C0037771" ; oboInOwl:id "HP:0002313" ; a owl:Class ; rdfs:label "Spastic paraparesis" ; rdfs:subClassOf obo:HP_0002061, obo:HP_0002385 . obo:HP_0002314 obo:IAO_0000115 "Deterioration of the tissues of the lateral corticospinal tracts." ; oboInOwl:hasAlternativeId "HP:0007254" ; oboInOwl:hasDbXref "UMLS:C1846566" ; oboInOwl:hasExactSynonym "Degeneration of lateral corticospinal tracts" ; oboInOwl:id "HP:0002314" ; a owl:Class ; rdfs:label "Degeneration of the lateral corticospinal tracts" ; rdfs:subClassOf obo:HP_0007372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002589 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002315 obo:IAO_0000115 "Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve." ; oboInOwl:hasAlternativeId "HP:0000266", "HP:0001354" ; oboInOwl:hasDbXref "MSH:D006261", "SNOMEDCT_US:25064002", "UMLS:C0018681" ; oboInOwl:hasExactSynonym "Headache", "Headaches" ; oboInOwl:id "HP:0002315" ; a owl:Class ; rdfs:comment "Headache is one of the most common types of recurrent pain as well as one of the most frequent symptoms in neurology. In addition to occasional headaches, there are well-defined headache disorders that vary in incidence, prevalence and duration and can be divided into two broad categories. In secondary headache disorders, headaches are attributed to another condition, such as brain tumor or head injury; for the primary disorders the headache is not due to another condition." ; rdfs:label "Headache" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0002317 oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:22631008", "SNOMEDCT_US:394616008", "UMLS:C0231686" ; oboInOwl:hasExactSynonym "Gait instability", "Unsteady walk" ; oboInOwl:id "HP:0002317" ; a owl:Class ; rdfs:label "Unsteady gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002318 oboInOwl:hasDbXref "SNOMEDCT_US:202664003", "UMLS:C0149645" ; oboInOwl:id "HP:0002318" ; a owl:Class ; rdfs:label "Cervical myelopathy" ; rdfs:subClassOf obo:HP_0002196 . obo:HP_0002321 obo:IAO_0000115 "An abnormal sensation of spinning while the body is actually stationary." ; oboInOwl:hasDbXref "MSH:D004244", "MSH:D014717", "SNOMEDCT_US:271789005", "SNOMEDCT_US:399090003", "SNOMEDCT_US:399153001", "SNOMEDCT_US:404640003", "UMLS:C0012833", "UMLS:C0042571" ; oboInOwl:hasExactSynonym "Dizzy spell" ; oboInOwl:hasRelatedSynonym "Dizziness" ; oboInOwl:id "HP:0002321" ; a owl:Class ; rdfs:label "Vertigo" ; rdfs:subClassOf obo:HP_0001751 . obo:HP_0002322 obo:IAO_0000115 "A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse." ; oboInOwl:hasDbXref "MSH:D014202", "SNOMEDCT_US:25082004", "UMLS:C0234379" ; oboInOwl:hasExactSynonym "Rest tremor", "Resting tremor", "Tremor at rest" ; oboInOwl:hasRelatedSynonym "Parkinsonian tremor" ; oboInOwl:id "HP:0002322" ; a owl:Class ; rdfs:comment "Resting tremor vanishes with active movement, but typically reappears after a few seconds when the arms are held outstretched (reemergent tremor). In Parkinson disease, rest tremor frequency is usually in the low to mid-range (3-6 Hz), and the amplitude is quite variable, from less than 1 cm to over 10 cm in width." ; rdfs:label "Resting tremor" ; rdfs:subClassOf obo:HP_0001337 . obo:HP_0002323 obo:IAO_0000115 "Anencephaly is a developmental anomaly characterized by a fetus that has no calvarium, with a lack of most or all of the fetus' brain tissue. Anencephaly belongs to a collective group known as neural tube defects (NTD) and is a result of the neural tube failing to close in its rostral end during fetal development." ; oboInOwl:hasDbXref "Fyler:4332", "MSH:D000757", "SNOMEDCT_US:89369001", "UMLS:C0002902" ; oboInOwl:hasExactSynonym "Embryonic anencephaly", "Fetal anencephaly", "Foetal anencephaly" ; oboInOwl:id "HP:0002323" ; a owl:Class ; rdfs:comment "See Figure 3 of PMID:32706613." ; rdfs:label "Anencephaly" ; rdfs:subClassOf obo:HP_0007364, obo:HP_0034237 . obo:HP_0002324 obo:IAO_0000115 "A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue." ; oboInOwl:hasDbXref "MSH:D006832", "SNOMEDCT_US:30023002", "UMLS:C0020225" ; oboInOwl:hasExactSynonym "Hydrancephaly" ; oboInOwl:id "HP:0002324" ; a owl:Class ; rdfs:label "Hydranencephaly" ; rdfs:subClassOf obo:HP_0002323 . obo:HP_0002326 oboInOwl:hasDbXref "MSH:D002546", "UMLS:C0917805" ; oboInOwl:hasExactSynonym "Mini stroke", "TIA", "Transient ischaemic attack", "Transient ischaemic attacks", "Transient ischemic attacks" ; oboInOwl:id "HP:0002326" ; a owl:Class ; rdfs:label "Transient ischemic attack" ; rdfs:subClassOf obo:HP_0001297, obo:HP_0002637 . obo:HP_0002329 obo:IAO_0000115 "Excessive daytime sleepiness." ; oboInOwl:hasDbXref "MSH:D012894", "SNOMEDCT_US:271782001", "SNOMEDCT_US:79519003", "UMLS:C0013144" ; oboInOwl:hasExactSynonym "Drowsiness", "Sleepy" ; oboInOwl:id "HP:0002329" ; a owl:Class ; rdfs:label "Drowsiness" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0002330 obo:IAO_0000115 "Attacks of disabling daytime drowsiness and low alertness." ; oboInOwl:hasDbXref "UMLS:C4025713" ; oboInOwl:id "HP:0002330" ; a owl:Class ; rdfs:label "Paroxysmal drowsiness" ; rdfs:subClassOf obo:HP_0002329 . obo:HP_0002331 obo:IAO_0000115 "Repeated episodes of headache with rapid onset, reaching a peak within minutes and of short duration (less than one hour) with pain that is throbbing, pulsating, or bursting in quality." ; oboInOwl:hasDbXref "UMLS:C1854337" ; oboInOwl:id "HP:0002331" ; a owl:Class ; rdfs:label "Recurrent paroxysmal headache" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0002332 obo:IAO_0000115 "The state of not having relationships with peers outside of school or organized activity appropriate to developmental level. This may be caused by behavioral or physical barriers." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "UMLS:C1845337" ; oboInOwl:id "HP:0002332" ; a owl:Class ; rdfs:label "Lack of peer relationships" ; rdfs:subClassOf obo:HP_5200016 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002333 obo:IAO_0000115 "Loss of previously present motor (i.e., movement) abilities." ; oboInOwl:hasDbXref "UMLS:C1866284" ; oboInOwl:hasExactSynonym "Progressive degeneration of movement" ; oboInOwl:id "HP:0002333" ; a owl:Class ; rdfs:label "Motor deterioration" ; rdfs:subClassOf obo:HP_0001268 . obo:HP_0002334 obo:IAO_0000115 "An anomaly of the vermis of cerebellum." ; oboInOwl:hasDbXref "UMLS:C4025712" ; oboInOwl:hasExactSynonym "Abnormality of the cerebellar vermis" ; oboInOwl:id "HP:0002334" ; a owl:Class ; rdfs:comment "The cerebellar vermis is the unpaired, median portion of the cerebellum that connects the two hemispheres." ; rdfs:label "Abnormal cerebellar vermis morphology" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002335 obo:IAO_0000115 "Congenital absence of the vermis of cerebellum." ; oboInOwl:hasAlternativeId "HP:0007125" ; oboInOwl:hasDbXref "MSH:C536293", "SNOMEDCT_US:253175003", "SNOMEDCT_US:716997004", "UMLS:C0431399" ; oboInOwl:hasExactSynonym "Cerebellar vermis aplasia", "Vermian agenesis" ; oboInOwl:id "HP:0002335" ; a owl:Class ; rdfs:label "Agenesis of cerebellar vermis" ; rdfs:subClassOf obo:HP_0006817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002339 obo:IAO_0000115 "Any structural abnormality of the caudate nucleus." ; oboInOwl:hasDbXref "UMLS:C4025711" ; oboInOwl:hasExactSynonym "Abnormality of the caudate nucleus" ; oboInOwl:id "HP:0002339" ; a owl:Class ; rdfs:comment "The caudate nucleus is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent." ; rdfs:label "Abnormal caudate nucleus morphology" ; rdfs:subClassOf obo:HP_0010994 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001873 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002340 oboInOwl:hasDbXref "UMLS:C1858116" ; oboInOwl:hasExactSynonym "Caudate degeneration" ; oboInOwl:id "HP:0002340" ; a owl:Class ; rdfs:label "Caudate atrophy" ; rdfs:subClassOf obo:HP_0007374 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001873 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002341 obo:IAO_0000115 "Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness." ; oboInOwl:hasAlternativeId "HP:0007145" ; oboInOwl:hasDbXref "UMLS:C0852866" ; oboInOwl:hasExactSynonym "Cervical cord compression myelopathy" ; oboInOwl:id "HP:0002341" ; a owl:Class ; rdfs:label "Cervical cord compression" ; rdfs:subClassOf obo:HP_0002176 . obo:HP_0002342 obo:IAO_0000115 "Moderate mental retardation is defined as an intelligence quotient (IQ) in the range of 35-49." ; oboInOwl:hasAlternativeId "HP:0007303" ; oboInOwl:hasDbXref "SNOMEDCT_US:61152003", "UMLS:C0026351" ; oboInOwl:hasExactSynonym "IQ between 34 and 49", "Mental retardation, moderate", "Moderate mental deficiency", "Moderate mental retardation" ; oboInOwl:id "HP:0002342" ; a owl:Class ; rdfs:label "Intellectual disability, moderate" ; rdfs:subClassOf obo:HP_0001249 . obo:HP_0002343 obo:IAO_0000115 "A form of hydrocephalus characterized by enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure upon lumbar puncture." ; oboInOwl:hasDbXref "MSH:D006850", "SNOMEDCT_US:30753002", "UMLS:C0020258" ; oboInOwl:hasExactSynonym "Normal-pressure hydrocephalus" ; oboInOwl:id "HP:0002343" ; a owl:Class ; rdfs:comment "Normal pressure hydrocephalus rarely occurs in patients younger than 60 years." ; rdfs:label "Normal pressure hydrocephalus" ; rdfs:subClassOf obo:HP_0000238 . obo:HP_0002344 oboInOwl:hasDbXref "UMLS:C1854838" ; oboInOwl:hasExactSynonym "Neurologic deterioration", "Neurologic deterioration, progressive", "Progressive mental deterioration", "Progressive neurodegeneration", "Worsening neurological symptoms" ; oboInOwl:id "HP:0002344" ; a owl:Class ; rdfs:label "Progressive neurologic deterioration" ; rdfs:subClassOf obo:HP_0001268 . obo:HP_0002345 obo:IAO_0000115 "A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement." ; oboInOwl:hasDbXref "MSH:D014202", "SNOMEDCT_US:30721006", "UMLS:C0234376", "UMLS:C4020853" ; oboInOwl:hasRelatedSynonym "Ataxic tremor" ; oboInOwl:id "HP:0002345" ; a owl:Class ; rdfs:comment "Action tremor occurs with voluntary contraction of muscle. Subforms of action tremor include postural, isometric, and kinetic tremors" ; rdfs:label "Action tremor" ; rdfs:subClassOf obo:HP_0001337 . obo:HP_0002346 obo:IAO_0000115 "An unintentional, oscillating to-and-fro muscle movement affecting head movement." ; oboInOwl:hasDbXref "UMLS:C0239882" ; oboInOwl:hasExactSynonym "Head tremor" ; oboInOwl:id "HP:0002346" ; a owl:Class ; rdfs:label "Head tremor" ; rdfs:subClassOf obo:HP_0030188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002349 obo:IAO_0000115 "A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile." ; oboInOwl:hasDbXref "MSH:D004828", "SNOMEDCT_US:117891000119100", "SNOMEDCT_US:79348005", "UMLS:C0234974" ; oboInOwl:hasExactSynonym "Focal aware seizures", "Focal seizure with retained awareness", "Focal seizure without impairment of awareness", "Focal seizure without impairment of consciousness or awareness", "Focal seizures without impairment of consciousness or awareness", "Partial seizure with retained awareness", "Partial seizure without impairment of awareness", "Simple partial seizure", "Simple partial seizures" ; oboInOwl:id "HP:0002349" ; a owl:Class ; rdfs:comment "In the previous (1981) ILAE classification of seizure types, the term 'simple partial seizure' was used to denote a focal aware seizure. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile. If awareness is preserved throughout, then the seizure is a focal aware seizure. Previously the terms simple partial was used to describe focal aware seizures." ; rdfs:label "Focal aware seizure" ; rdfs:subClassOf obo:HP_0007359 . obo:HP_0002350 oboInOwl:hasDbXref "UMLS:C1847762" ; oboInOwl:hasExactSynonym "Cerebellar cysts" ; oboInOwl:id "HP:0002350" ; a owl:Class ; rdfs:label "Cerebellar cyst" ; rdfs:subClassOf obo:HP_0002438, obo:HP_0010576 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002352 obo:IAO_0000115 "This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells." ; oboInOwl:hasAlternativeId "HP:0006838", "HP:0007073" ; oboInOwl:hasDbXref "MSH:D056784", "SNOMEDCT_US:22811006", "UMLS:C0270612" ; oboInOwl:id "HP:0002352" ; a owl:Class ; rdfs:comment "This feature can be demonstrated by magnetic resonance imaging or computer tomography." ; rdfs:label "Leukoencephalopathy" ; rdfs:subClassOf obo:HP_0002060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002353 obo:IAO_0000115 "Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp." ; oboInOwl:hasAlternativeId "HP:0001346", "HP:0002429", "HP:0006841" ; oboInOwl:hasDbXref "SNOMEDCT_US:274521009", "UMLS:C0151611" ; oboInOwl:hasExactSynonym "Abnormal EEG", "Abnormal electroencephalogram", "EEG abnormalities", "Electroencephalogram abnormal", "Electroencephalogram abnormalities" ; oboInOwl:id "HP:0002353" ; a owl:Class ; rdfs:label "EEG abnormality" ; rdfs:subClassOf obo:HP_0030178 . obo:HP_0002354 obo:IAO_0000115 "An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness." ; oboInOwl:hasAlternativeId "HP:0000747", "HP:0002081" ; oboInOwl:hasDbXref "MSH:D008569", "SNOMEDCT_US:386807006", "SNOMEDCT_US:55533009", "UMLS:C0233794", "UMLS:C0542476", "UMLS:C0751295" ; oboInOwl:hasExactSynonym "Forgetfulness", "Memory impairment", "Memory loss", "Memory problems", "Poor memory" ; oboInOwl:id "HP:0002354" ; a owl:Class ; rdfs:comment "Affected individuals tend to lose their train of thought in conversation, begin tasks but forget their intention while doing it, repeat things often during conversations, and have difficulties in tasks of daily living." ; rdfs:label "Memory impairment" ; rdfs:subClassOf obo:HP_0100543 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002355 obo:IAO_0000115 "Reduced ability to walk (ambulate)." ; oboInOwl:hasAlternativeId "HP:0007101", "HP:0009030" ; oboInOwl:hasDbXref "MSH:D051346", "SNOMEDCT_US:228158008", "UMLS:C0311394" ; oboInOwl:hasExactSynonym "Difficulty in walking", "Difficulty walking", "Walking disability" ; oboInOwl:id "HP:0002355" ; a owl:Class ; rdfs:label "Difficulty walking" ; rdfs:subClassOf obo:HP_0001288, obo:HP_0004302 . obo:HP_0002356 obo:IAO_0000115 "A focal dystonia of the fingers, hand, and/or forearm that appears when the affected person attempts to do a task that requires fine motor movements such as writing or playing a musical instrument." ; oboInOwl:hasDbXref "MSH:D020821", "SNOMEDCT_US:52008007", "UMLS:C0154676" ; oboInOwl:hasExactSynonym "Writer's cramp" ; oboInOwl:id "HP:0002356" ; a owl:Class ; rdfs:label "Writer's cramp" ; rdfs:subClassOf obo:HP_0004373 . obo:HP_0002357 obo:IAO_0100001 "HP:0002381" ; oboInOwl:id "HP:0002357" ; a owl:Class ; rdfs:label "obsolete Dysphasia" ; owl:deprecated true . obo:HP_0002359 oboInOwl:hasDbXref "UMLS:C0850703" ; oboInOwl:hasExactSynonym "Frequent falls" ; oboInOwl:id "HP:0002359" ; a owl:Class ; rdfs:label "Frequent falls" ; rdfs:subClassOf obo:HP_0002311, obo:HP_0004302 . obo:HP_0002360 obo:IAO_0000115 "An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness." ; oboInOwl:hasDbXref "SNOMEDCT_US:53888004", "UMLS:C0037317" ; oboInOwl:hasExactSynonym "Difficulty sleeping", "Sleep disturbances", "Sleep dysfunction", "Trouble sleeping" ; oboInOwl:id "HP:0002360" ; a owl:Class ; rdfs:label "Sleep disturbance" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0030431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002361 obo:IAO_0000115 "Loss of previously present mental and motor abilities." ; oboInOwl:hasDbXref "UMLS:C1836842" ; oboInOwl:hasExactSynonym "Psychomotor degeneration" ; oboInOwl:id "HP:0002361" ; a owl:Class ; rdfs:label "Psychomotor deterioration" ; rdfs:subClassOf obo:HP_0001268 . obo:HP_0002362 obo:IAO_0000115 "A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground." ; oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:43005009", "UMLS:C0231688" ; oboInOwl:hasExactSynonym "Shuffled walk" ; oboInOwl:id "HP:0002362" ; a owl:Class ; rdfs:label "Shuffling gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002363 obo:IAO_0000115 "An anomaly of the brainstem." ; oboInOwl:hasDbXref "UMLS:C1850601" ; oboInOwl:hasExactSynonym "Abnormal shape of brainstem", "Abnormality of brainstem morphology", "Abnormality of the brainstem" ; oboInOwl:id "HP:0002363" ; a owl:Class ; rdfs:label "Abnormal brainstem morphology" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002298 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002365 obo:IAO_0000115 "Underdevelopment of the brainstem." ; oboInOwl:hasDbXref "UMLS:C1842688" ; oboInOwl:hasExactSynonym "Brainstem hypoplasia", "Hypoplastic brain stem", "Hypoplastic brainstem", "Small brainstem", "Underdeveloped brainstem" ; oboInOwl:id "HP:0002365" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by magnetic resonance imaging." ; rdfs:label "Hypoplasia of the brainstem" ; rdfs:subClassOf obo:HP_0007362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002298 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002366 obo:IAO_0000115 "Any structural anomaly of the lower motor neuron." ; oboInOwl:hasAlternativeId "HP:0007276" ; oboInOwl:hasDbXref "UMLS:C1865412" ; oboInOwl:hasExactSynonym "Lower motor neuron disease", "Lower motor neuron manifestations", "Lower motor neuron signs" ; oboInOwl:id "HP:0002366" ; a owl:Class ; rdfs:comment """previous def: 'has part' some (quality and ('inheres in' some 'Lower motor neuron (adult human)') and ('has modifier' some abnormal))""" ; rdfs:label "Abnormal lower motor neuron morphology" ; rdfs:subClassOf obo:HP_0000759, obo:HP_0002450 . obo:HP_0002367 obo:IAO_0000115 "Visual perceptions that are not elicited by a corresponding stimulus from the outside world." ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:64269007", "UMLS:C0233763" ; oboInOwl:hasExactSynonym "Visual hallucinations" ; oboInOwl:id "HP:0002367" ; a owl:Class ; rdfs:label "Visual hallucinations" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0002370 oboInOwl:hasDbXref "UMLS:C0563243" ; oboInOwl:hasExactSynonym "Poor coordination" ; oboInOwl:id "HP:0002370" ; a owl:Class ; rdfs:label "Poor coordination" ; rdfs:subClassOf obo:HP_0002311 . obo:HP_0002371 oboInOwl:hasDbXref "UMLS:C0542223" ; oboInOwl:hasExactSynonym "Loss of speech" ; oboInOwl:id "HP:0002371" ; a owl:Class ; rdfs:label "Loss of speech" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002372 obo:IAO_0000115 "Lack of observable abnormal electroencephalographic (EEG) patterns in an individual with a history of seizures. About half of individuals with epilepsy show interictal epileptiform discharges upon the first investigation. The yield can be increased by repeated studies, sleep studies, or by ambulatory EEG recordings over 24 hours. Normal interictal EEG is a sign that can be useful in the differential diagnosis." ; oboInOwl:hasDbXref "UMLS:C1843146" ; oboInOwl:id "HP:0002372" ; a owl:Class ; rdfs:label "Normal interictal EEG" ; rdfs:subClassOf obo:HP_0025373 . obo:HP_0002373 obo:IAO_0000115 "A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years." ; oboInOwl:hasAlternativeId "HP:0002175", "HP:0007102" ; oboInOwl:hasDbXref "MSH:D003294", "SNOMEDCT_US:41497008", "UMLS:C0009952" ; oboInOwl:hasExactSynonym "Febrile convulsion", "Febrile seizures", "Fever induced seizures", "Seizures, febrile, in early childhood", "Seizures, generalized, associated with fever" ; oboInOwl:id "HP:0002373" ; a owl:Class ; rdfs:comment "Typically febrile seizures are limited to the age range of 3 months to 6 years and not accompanied or preceded by afebrile seizures; in this case febrile seizures are not considered indicative of epilepsy. When febrile seizures occur prior to the age of 3 months, or continue beyond the 6th birthday, or when a person has both febrile seizures and afebrile generalized tonic-clonic seizures then a diagnosis of Febrile Seizures Plus (an epilepsy syndrome) may be made." ; rdfs:label "Febrile seizure (within the age range of 3 months to 6 years)" ; rdfs:subClassOf obo:HP_0032894 . obo:HP_0002374 oboInOwl:hasDbXref "UMLS:C4025710" ; oboInOwl:hasExactSynonym "Diminished movement" ; oboInOwl:id "HP:0002374" ; a owl:Class ; rdfs:label "Diminished movement" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0002375 obo:IAO_0000115 "Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency." ; oboInOwl:hasAlternativeId "HP:0002603", "HP:0006795" ; oboInOwl:hasDbXref "MSH:D018476", "SNOMEDCT_US:255385008", "SNOMEDCT_US:43994002", "UMLS:C0086439" ; oboInOwl:hasExactSynonym "Decreased muscle movement", "Decreased spontaneous movement", "Decreased spontaneous movements" ; oboInOwl:id "HP:0002375" ; a owl:Class ; rdfs:label "Hypokinesia" ; rdfs:subClassOf obo:HP_0002374 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050881 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002376 obo:IAO_0000115 "Loss of developmental skills, as manifested by loss of developmental milestones." ; oboInOwl:hasAlternativeId "HP:0002471", "HP:0002489", "HP:0006797", "HP:0006828", "HP:0006854", "HP:0007037", "HP:0007242", "HP:0007247" ; oboInOwl:hasDbXref "SNOMEDCT_US:609225004", "UMLS:C1836550", "UMLS:C1836830", "UMLS:C1850493", "UMLS:C1855009", "UMLS:C1855019", "UMLS:C1855996", "UMLS:C1857121", "UMLS:C1859678" ; oboInOwl:hasExactSynonym "Loss of developmental milestones", "Mental deterioration in childhood", "Neurodevelopmental regression", "Psychomotor regression", "Psychomotor regression beginning in infancy", "Psychomotor regression in infants", "Psychomotor regression, progressive" ; oboInOwl:id "HP:0002376" ; a owl:Class ; rdfs:comment "Developmental regression is said to occur when a child that has reached a certain psychomotor developmental stage starts to regress and to lose the acquired milestones." ; rdfs:label "Developmental regression" ; rdfs:subClassOf obo:HP_0012759 . obo:HP_0002377 obo:IAO_0100001 "HP:0006824" ; oboInOwl:id "HP:0002377" ; a owl:Class ; rdfs:label "obsolete Paraganglioma-related cranial nerve palsy" ; owl:deprecated true . obo:HP_0002378 obo:IAO_0000115 "An unintentional, oscillating to-and-fro muscle movement affecting the hand." ; oboInOwl:hasDbXref "UMLS:C0239842" ; oboInOwl:hasExactSynonym "Hand tremor", "Tremor of hand", "Tremor of hands", "tremors in hands" ; oboInOwl:id "HP:0002378" ; a owl:Class ; rdfs:label "Hand tremor" ; rdfs:subClassOf obo:HP_0030188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002380 obo:IAO_0000115 "Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units." ; oboInOwl:hasAlternativeId "HP:0002468", "HP:0007092" ; oboInOwl:hasDbXref "MSH:D005207", "SNOMEDCT_US:82470000", "UMLS:C0015644" ; oboInOwl:hasExactSynonym "Fasciculation", "Muscle fasciculation", "Muscle twitch" ; oboInOwl:id "HP:0002380" ; a owl:Class ; rdfs:comment "This finding can be visible clinically and can be demonstrated by electromyography (EMG)." ; rdfs:label "Fasciculations" ; rdfs:subClassOf obo:HP_0004305 . obo:HP_0002381 obo:IAO_0000115 "An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write." ; oboInOwl:hasAlternativeId "HP:0002357" ; oboInOwl:hasDbXref "MSH:D001037", "SNOMEDCT_US:87486003", "UMLS:C0003537" ; oboInOwl:hasExactSynonym "Difficulty finding words", "Losing words", "Loss of words" ; oboInOwl:id "HP:0002381" ; a owl:Class ; rdfs:comment "Aphasia is caused by brain injury. The most common cause is stroke, but aphasia can also be caused by other factors such as head trauma, brain tumors, or infections. The terms aphasia and dysphasia are usually considered to be synonymous, but the word dysphasia has been used inconsistently and it is recommended to no longer use the term dysphasia." ; rdfs:label "Aphasia" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002383 obo:IAO_0000115 "A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity." ; oboInOwl:hasDbXref "MSH:D004660", "SNOMEDCT_US:45170000", "UMLS:C0014038" ; oboInOwl:hasExactSynonym "Brain inflammation" ; oboInOwl:id "HP:0002383" ; a owl:Class ; rdfs:label "Infectious encephalitis" ; rdfs:subClassOf obo:HP_0011450 . obo:HP_0002384 obo:IAO_0000115 "Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure." ; oboInOwl:hasAlternativeId "HP:0002278" ; oboInOwl:hasDbXref "SNOMEDCT_US:4103001", "UMLS:C0149958", "UMLS:C0270834" ; oboInOwl:hasExactSynonym "Complex focal seizures", "Complex partial seizure", "Complex partial seizures", "Dyscognitive seizures", "Focal dyscognitive seizure", "Focal impaired awareness seizures", "Focal seizure with impairment of awareness", "Focal seizure with loss of awareness", "Focal seizures with impairment of consciousness or awareness", "Localised dyscognitive seizure", "Localised seizure with impaired awareness", "Localised seizure with loss of awareness", "Localized dyscognitive seizure", "Localized seizure with impaired awareness", "Localized seizure with loss of awareness", "Partial dyscognitive seizure", "Partial seizure with impairment of awareness", "Partial seizure with loss of awareness" ; oboInOwl:id "HP:0002384" ; a owl:Class ; rdfs:comment "Awareness during a seizure is defined as the person being fully aware of themselves and their environment throughout the seizure, even if immobile. If awareness is impaired at any point during the seizure, the seizure is a focal impaired awareness seizure. The degree of loss of awareness may vary. The terms 'complex partial seizure' and 'focal dyscognitive seizure' were previously used to denote a focal impaired awareness seizure." ; rdfs:label "Focal impaired awareness seizure" ; rdfs:subClassOf obo:HP_0007359, obo:HP_0011146 . obo:HP_0002385 obo:IAO_0000115 "Weakness or partial paralysis in the lower limbs." ; oboInOwl:hasDbXref "MSH:D020335", "SNOMEDCT_US:1845001", "UMLS:C0221166" ; oboInOwl:hasExactSynonym "Partial paralysis of legs" ; oboInOwl:id "HP:0002385" ; a owl:Class ; rdfs:comment "Diseases of the spinal cord that affect motor function of the legs produce a gait characterized by both leg weakness and spasticity." ; rdfs:label "Paraparesis" ; rdfs:subClassOf obo:HP_0010551 . obo:HP_0002389 obo:IAO_0000115 "If the two laminae of the septum pellucidum are not fused then a fluid-filled space or cavum is present. The cavum septum pellucidum is present at birth but usually obliterates by the age of 3 to 6 months. It is up to 1cm in width and the walls are parallel. It is an enclosed space and is not part of the ventricular system or connected with the subarachnoid space." ; oboInOwl:hasAlternativeId "HP:0006884", "HP:0007091", "HP:0007336" ; oboInOwl:hasDbXref "UMLS:C1840380" ; oboInOwl:hasExactSynonym "Large cavum septi pellucidi", "Persistent cavum septum pellucidum", "Widened cavum septum pellucidum" ; oboInOwl:id "HP:0002389" ; a owl:Class ; rdfs:label "Cavum septum pellucidum" ; rdfs:subClassOf obo:HP_0007375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000651 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002390 oboInOwl:hasDbXref "SNOMEDCT_US:261482004", "UMLS:C0348023" ; oboInOwl:id "HP:0002390" ; a owl:Class ; rdfs:label "Spinal arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0100026 . obo:HP_0002392 obo:IAO_0000115 "The presence of complexes of repetitive spikes and waves in EEG." ; oboInOwl:hasDbXref "UMLS:C4021757" ; oboInOwl:hasExactSynonym "EEG: spike and multispike waves, 3-4 hz" ; oboInOwl:id "HP:0002392" ; a owl:Class ; rdfs:label "EEG with polyspike wave complexes" ; rdfs:subClassOf obo:HP_0010850 . obo:HP_0002395 oboInOwl:hasAlternativeId "HP:0007245", "HP:0007288" ; oboInOwl:hasDbXref "UMLS:C1836696" ; oboInOwl:hasExactSynonym "Brisk lower extremity reflexes", "Hyperreflexia in lower limbs", "Hyperreflexia in the lower limbs", "Increased deep tendon reflexes in the lower limbs", "Leg hyperreflexia", "Overactive lower leg reflex" ; oboInOwl:id "HP:0002395" ; a owl:Class ; rdfs:label "Lower limb hyperreflexia" ; rdfs:subClassOf obo:HP_0001347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002396 obo:IAO_0000115 "A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched)." ; oboInOwl:hasDbXref "MSH:D009127", "SNOMEDCT_US:55630000", "UMLS:C0151564" ; oboInOwl:id "HP:0002396" ; a owl:Class ; rdfs:comment "Cogwheel rigidity is a typical manifestation of Parkinson disease." ; rdfs:label "Cogwheel rigidity" ; rdfs:subClassOf obo:HP_0002063 . obo:HP_0002398 oboInOwl:hasAlternativeId "HP:0007136", "HP:0008312" ; oboInOwl:hasDbXref "UMLS:C1843505" ; oboInOwl:hasExactSynonym "Anterior horn cell loss", "Degeneration of alpha-motor neurons in anterior horn cells of the spinal cord", "Degeneration of spinal cord anterior horn cells", "Loss of spinal cord anterior horn cells", "Progressive loss of anterior horn cells", "Spinal cord anterior horn cell degeneration" ; oboInOwl:id "HP:0002398" ; a owl:Class ; rdfs:label "Degeneration of anterior horn cells" ; rdfs:subClassOf obo:HP_0006802, obo:HP_0007373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002401 obo:IAO_0000115 "No consensus exists on what a stroke-like episode is, but these episodes can be functionally defined as a new neurological deficit, occurring with or without the context of seizures, which last longer than 24 hours." ; oboInOwl:hasDbXref "UMLS:C1857287" ; oboInOwl:hasExactSynonym "Stroke-like episodes", "Strokelike episodes" ; oboInOwl:id "HP:0002401" ; a owl:Class ; rdfs:comment "Stroke-like episodes are phenotypic features predominantly of mitochondrial disorders, most frequently mitochondrial encephalopathy, lactacidosis, SLE (MELAS)-syndrome, and mimic the clinical manifestations of ischemic stroke to some extent." ; rdfs:label "Stroke-like episode" ; rdfs:subClassOf obo:HP_0001297 . obo:HP_0002403 obo:IAO_0000115 "The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception." ; oboInOwl:hasDbXref "SNOMEDCT_US:298310004", "UMLS:C0240914" ; oboInOwl:id "HP:0002403" ; a owl:Class ; rdfs:label "Positive Romberg sign" ; rdfs:subClassOf obo:HP_0010831 . obo:HP_0002404 obo:IAO_0000115 "Increased width of the superior cerebellar peduncle." ; oboInOwl:hasDbXref "UMLS:C4021756" ; oboInOwl:hasExactSynonym "Thick cerebellar peduncles" ; oboInOwl:id "HP:0002404" ; a owl:Class ; rdfs:label "Thickened superior cerebellar peduncle" ; rdfs:subClassOf obo:HP_0011932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002406 obo:IAO_0000115 "A type of dysmetria involving the limbs." ; oboInOwl:hasDbXref "UMLS:C1854489", "UMLS:C4280577" ; oboInOwl:hasNarrowSynonym "Uncoordinated limb movement" ; oboInOwl:id "HP:0002406" ; a owl:Class ; rdfs:label "Limb dysmetria" ; rdfs:subClassOf obo:HP_0001310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001310 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002408 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the brain." ; oboInOwl:hasDbXref "Fyler:2201", "MSH:D002538", "SNOMEDCT_US:234142008", "UMLS:C0917804" ; oboInOwl:hasExactSynonym "Cerebral AV malformation" ; oboInOwl:id "HP:0002408" ; a owl:Class ; rdfs:label "Cerebral arteriovenous malformation" ; rdfs:subClassOf obo:HP_0100026, obo:HP_0100659 . obo:HP_0002410 obo:IAO_0000115 "Stenosis of the cerebral aqueduct (also known as the mesencephalic duct, aqueductus mesencephali, or aqueduct of Sylvius), which connects the third cerebral ventricle in the diencephalon to the fourth ventricle, which is between the pons and cerebellum." ; oboInOwl:hasDbXref "MSH:D006849", "UMLS:C2936786" ; oboInOwl:hasExactSynonym "Aqueduct of Sylvius stenosis", "Aqueduct stenosis", "Narrowing of aqueduct of Sylvius" ; oboInOwl:id "HP:0002410" ; a owl:Class ; rdfs:label "Aqueductal stenosis" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002289 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002411 obo:IAO_0000115 "Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle." ; oboInOwl:hasDbXref "MSH:D020385", "SNOMEDCT_US:27678003", "UMLS:C0684219" ; oboInOwl:id "HP:0002411" ; a owl:Class ; rdfs:comment "Myokymia is characterized electrophysiologically by rhythmic or semi-rhythmic bursts of a single motor unit discharging several times a second at a rate of 3-8 Hz. These myokymic discharges are nonsynchronous in different muscles or even in the same muscle, with intervals of 100-200 milliseconds separating individual bursts. The spontaneous discharges are not initiated by voluntary movement, although they may increase with such activity." ; rdfs:label "Myokymia" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0002414 obo:IAO_0000115 "Incomplete closure of the embryonic neural tube, whereby some vertebral arches remain unfused and open. The mildest form is spina bifida occulta, followed by meningocele and meningomyelocele." ; oboInOwl:hasBroadSynonym "Split spine" ; oboInOwl:hasDbXref "Fyler:4157", "MSH:D016135", "SNOMEDCT_US:67531005", "UMLS:C0080178" ; oboInOwl:id "HP:0002414" ; a owl:Class ; rdfs:label "Spina bifida" ; rdfs:subClassOf obo:HP_0010301 . obo:HP_0002415 obo:IAO_0000115 "Leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes. Symmetric white matter involvement at MRI is a typical finding in patients with leukodystrophies." ; oboInOwl:hasAlternativeId "HP:0006926", "HP:0007079" ; oboInOwl:hasDbXref "SNOMEDCT_US:192781003", "UMLS:C0023520" ; oboInOwl:hasExactSynonym "Degeneration of white matter of brain" ; oboInOwl:id "HP:0002415" ; a owl:Class ; rdfs:comment "The deterioration coincides with clinical regression of skills, and in the most severe cases neurological devastation. Leukodystrophy should be distinguished from leukoencephalopathy (defect causing secondary myelin damage). Note that the term leukodystrophy is most often used to refer to a disease rather than a phenotypic feature, and a more precise description is to be preferred if possible." ; rdfs:label "Leukodystrophy" ; rdfs:subClassOf obo:HP_0011400 . obo:HP_0002416 obo:IAO_0000115 "Cerebral cysts, usually located in the wall of the caudate nucleus or in the caudothalamic groove. They are found in up to 5.2% of all neonates, using transfontanellar ultrasound in the first days of life." ; oboInOwl:hasDbXref "UMLS:C1833431" ; oboInOwl:hasExactSynonym "Subependymal germinolytic cyst", "Subependymal pseudocyst" ; oboInOwl:id "HP:0002416" ; a owl:Class ; rdfs:comment "In the vast majority of cases, a simple persistence of the germinal matrix is proposed to explain their presence in asymptomatic preterm neonates. Viral infections, mainly with CMV and rubella, are commonly found when the pseudocysts are associated with other abnormalities of the central nervous system. The pseudocysts are then often multilocular." ; rdfs:label "Subependymal cysts" ; rdfs:subClassOf obo:HP_0002118, obo:HP_0010576 . obo:HP_0002418 obo:IAO_0000115 "An abnormality of the midbrain, which has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct." ; oboInOwl:hasDbXref "UMLS:C4021755" ; oboInOwl:hasExactSynonym "Abnormal shape of midbrain", "Abnormality of midbrain morphology", "Abnormality of the mesencephalon", "Abnormality of the midbrain" ; oboInOwl:id "HP:0002418" ; a owl:Class ; rdfs:label "Abnormal midbrain morphology" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001891 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002419 obo:IAO_0000115 "An abnormal appearance of the midbrain in axial magnetic resonance imaging in which the elongated superior cerebellar peduncles give the midbrain an appearance reminiscent of a molar or wisdom tooth." ; oboInOwl:hasDbXref "UMLS:C1865060" ; oboInOwl:hasExactSynonym "Molar tooth sign", "Molar tooth sign on brain imaging", "Molar tooth sign on imaging" ; oboInOwl:id "HP:0002419" ; a owl:Class ; rdfs:comment "Molar tooth appearance results from a lack of normal decussation of superior cerebellar peduncular fiber tracts which in turn leads to enlargement of the peduncles, which also follow a more horizontal course. The absence of crossing fibers also leads to a reduction in the anteroposterior diameter of the midbrain and deepening of the interpeduncular cistern." ; rdfs:label "Molar tooth sign on MRI" ; rdfs:subClassOf obo:HP_0002418 . obo:HP_0002421 obo:IAO_0000115 "Difficulty to maintain correct position of the head while standing or sitting." ; oboInOwl:hasDbXref "UMLS:C1836038" ; oboInOwl:hasExactSynonym "Poor head control" ; oboInOwl:id "HP:0002421" ; a owl:Class ; rdfs:label "Poor head control" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0002423 obo:IAO_0000115 "Long-tract signs refer to symptoms that are attributable to the involvement of the long fiber tracts in the spinal cord, which connect the spinal cord to the brain and mediate spinal and motor functions." ; oboInOwl:hasDbXref "UMLS:C1865903" ; oboInOwl:hasExactSynonym "Long tract signs" ; oboInOwl:id "HP:0002423" ; a owl:Class ; rdfs:label "Long-tract signs" ; rdfs:subClassOf obo:HP_0034482 . obo:HP_0002425 obo:IAO_0000115 "A defect in the motor ability that enables speech." ; oboInOwl:hasDbXref "SNOMEDCT_US:48257004", "UMLS:C0234517" ; oboInOwl:hasExactSynonym "Loss of articulate speech" ; oboInOwl:id "HP:0002425" ; a owl:Class ; rdfs:label "Anarthria" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002427 obo:IAO_0000115 "Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it." ; oboInOwl:hasDbXref "MSH:D001039", "SNOMEDCT_US:229654003", "SNOMEDCT_US:229665008", "SNOMEDCT_US:328681008", "UMLS:C0003550", "UMLS:C0917814" ; oboInOwl:hasExactSynonym "Broca's aphasia", "Loss of expressive speech", "Motor aphasia", "Non-fluent aphasia" ; oboInOwl:id "HP:0002427" ; a owl:Class ; rdfs:label "Expressive aphasia" ; rdfs:subClassOf obo:HP_0002381 . obo:HP_0002435 obo:IAO_0000115 "Protrusion of the meninges through a defect of the skull or vertebral column." ; oboInOwl:hasDbXref "MSH:D008588", "SNOMEDCT_US:171131006", "UMLS:C0025299" ; oboInOwl:id "HP:0002435" ; a owl:Class ; rdfs:label "Meningocele" ; rdfs:subClassOf obo:HP_0010651, obo:HP_0034238 . obo:HP_0002436 obo:IAO_0000115 "A herniation of meninges through a congenital bone defect in the skull in the occipital region." ; oboInOwl:hasDbXref "SNOMEDCT_US:445468002", "UMLS:C1848652" ; oboInOwl:id "HP:0002436" ; a owl:Class ; rdfs:label "Occipital meningocele" ; rdfs:subClassOf obo:HP_0002435 . obo:HP_0002438 oboInOwl:hasDbXref "UMLS:C4025708" ; oboInOwl:id "HP:0002438" ; a owl:Class ; rdfs:label "Cerebellar malformation" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002439 oboInOwl:hasDbXref "UMLS:C1836151" ; oboInOwl:id "HP:0002439" ; a owl:Class ; rdfs:label "Frontolimbic dementia" ; rdfs:subClassOf obo:HP_0000726 . obo:HP_0002442 obo:IAO_0000115 "A specific learning disability involving mathematics and arithmetic." ; oboInOwl:hasBroadSynonym "Difficulty making arithmetical calculations" ; oboInOwl:hasDbXref "SNOMEDCT_US:47916000", "UMLS:C1411876", "UMLS:C4280576" ; oboInOwl:id "HP:0002442" ; a owl:Class ; rdfs:label "Dyscalculia" ; rdfs:subClassOf obo:HP_0001328 . obo:HP_0002444 obo:IAO_0000115 "The presence of a hamartoma of the hypothalamus." ; oboInOwl:hasDbXref "MSH:C537158", "SNOMEDCT_US:237714006", "UMLS:C0342418" ; oboInOwl:id "HP:0002444" ; a owl:Class ; rdfs:comment "Hypothalamic hamartoma is a malformation, not a tumor. Hypothalamic hamartomas grow at the rate of, or slower than, the surrounding brain tissue. A hamartoma of the hypothalamus appears as a non-enhancing mass in the floor of the third ventricle posterior to the optic chiasm that is isointense to grey matter on T1 and T2 pulse sequences of an MRI, but may have distinct intensity on FLAIR (neither cranial CT examination nor cranial ultrasound examination is adequate for diagnosis of hypothalamic hamartom). Individuals with hypothalamic hamartomas may have neurologic symptoms, although most are asymptomatic. Removal of the hypothalamic hamartoma is not indicated and often results in iatrogenic pituitary insufficiency." ; rdfs:label "Hypothalamic hamartoma" ; rdfs:subClassOf obo:HP_0009731, obo:HP_0012286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002445 obo:IAO_0000115 "Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord." ; oboInOwl:hasAlternativeId "HP:0010552" ; oboInOwl:hasDbXref "MSH:D011782", "SNOMEDCT_US:11538006", "UMLS:C0034372" ; oboInOwl:hasExactSynonym "Paralysis of all four limbs", "Quadriplegia" ; oboInOwl:id "HP:0002445" ; a owl:Class ; rdfs:label "Tetraplegia" ; rdfs:subClassOf obo:HP_0030182 . obo:HP_0002446 obo:IAO_0000115 "Proliferation of astrocytes in the area of a lesion of the central nervous system." ; oboInOwl:hasBroadSynonym "Increase in astrocyte number" ; oboInOwl:hasDbXref "MSH:D005911", "SNOMEDCT_US:81415000", "UMLS:C3887640" ; oboInOwl:id "HP:0002446" ; a owl:Class ; rdfs:label "Astrocytosis" ; rdfs:subClassOf obo:HP_0100707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0016049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:CL_0000127 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002448 oboInOwl:hasBroadSynonym "Progressive brain disease" ; oboInOwl:hasDbXref "UMLS:C1838578", "UMLS:C4280575" ; oboInOwl:id "HP:0002448" ; a owl:Class ; rdfs:label "Progressive encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0002450 obo:IAO_0000115 "Any structural anomaly that affects the motor neuron." ; oboInOwl:hasDbXref "UMLS:C4025707" ; oboInOwl:hasExactSynonym "Abnormal shape of motor neuron" ; oboInOwl:id "HP:0002450" ; a owl:Class ; rdfs:label "Abnormal motor neuron morphology" ; rdfs:subClassOf obo:HP_0012757 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002451 obo:IAO_0000115 "A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the limbs." ; oboInOwl:hasDbXref "MSH:D004421", "UMLS:C0751093" ; oboInOwl:id "HP:0002451" ; a owl:Class ; rdfs:label "Limb dystonia" ; rdfs:subClassOf obo:HP_0001332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000598 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002453 obo:IAO_0000115 "An abnormality of the globus pallidus." ; oboInOwl:hasAlternativeId "HP:0007040" ; oboInOwl:hasDbXref "UMLS:C4025706" ; oboInOwl:id "HP:0002453" ; a owl:Class ; rdfs:comment "The globus pallidus is a cerebral nucleus located medially to the putamen and laterally to the internal capsule." ; rdfs:label "Abnormal globus pallidus morphology" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001875 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002454 obo:IAO_0000115 "The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus." ; oboInOwl:hasAlternativeId "HP:0012677" ; oboInOwl:hasDbXref "UMLS:C4025705" ; oboInOwl:id "HP:0002454" ; a owl:Class ; rdfs:comment "This sign is observed upon magnetic resonance tomography (MRI). It can be seen in several diseases including Hallervorden-Spatz syndrome, where the pathophysiology has been hypothesized to be related to iron deposition in the globus pallidus (associated with low signal intensity on T2-weighted images) accompanied by other pathological processes such as gliosis and water accumulation that are responsible for the high signal intensity at the central globus pallidus." ; rdfs:label "Eye of the tiger anomaly of globus pallidus" ; rdfs:subClassOf obo:HP_0002453, obo:HP_0012675 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001875 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002457 oboInOwl:hasDbXref "SNOMEDCT_US:271799000", "UMLS:C0476217" ; oboInOwl:hasExactSynonym "Abnormal head movements" ; oboInOwl:id "HP:0002457" ; a owl:Class ; rdfs:label "Abnormal head movements" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0002459 obo:IAO_0100001 "HP:0012332" ; oboInOwl:id "HP:0002459" ; a owl:Class ; rdfs:label "obsolete Dysautonomia" ; owl:deprecated true . obo:HP_0002460 obo:IAO_0000115 "Reduced strength of the musculature of the distal extremities." ; oboInOwl:hasAlternativeId "HP:0002598", "HP:0002935", "HP:0003497", "HP:0006940", "HP:0009008" ; oboInOwl:hasDbXref "SNOMEDCT_US:249942005", "UMLS:C0427065", "UMLS:C1864696" ; oboInOwl:hasExactSynonym "Distal limb muscle weakness", "Distal limb weakness", "Distal muscular weakness", "Distal paresis", "Muscle weakness, distal", "Muscle weakness, distal limbs, due to neuronopathy", "Weakness of distal muscles", "Weakness of outermost muscles" ; oboInOwl:hasRelatedSynonym "Distal limb muscle weakness due to peripheral neuropathy" ; oboInOwl:id "HP:0002460" ; a owl:Class ; rdfs:comment "Typically, at onset the lower limbs are more affected than upper limbs. The distribution of weakness is often roughly symmetric." ; rdfs:label "Distal muscle weakness" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0002461 oboInOwl:hasDbXref "UMLS:C1859273" ; oboInOwl:id "HP:0002461" ; a owl:Class ; rdfs:label "Dense calcifications in the cerebellar dentate nucleus" ; rdfs:subClassOf obo:HP_0007352, obo:HP_0100321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002463 obo:IAO_0000115 "Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "MSH:D007806", "SNOMEDCT_US:62305002", "UMLS:C0023015" ; oboInOwl:hasExactSynonym "Language disorder" ; oboInOwl:id "HP:0002463" ; a owl:Class ; rdfs:label "Language impairment" ; rdfs:subClassOf obo:HP_0034434 . obo:HP_0002464 obo:IAO_0000115 "A type of dysarthria related to bilateral damage of the upper motor neuron tracts of the pyramidal and extra- pyramidal tracts. Speech of affected individuals is slow, effortful, and has a harsh vocal quality." ; oboInOwl:hasDbXref "MSH:D004401", "SNOMEDCT_US:229684006", "UMLS:C0454596" ; oboInOwl:hasExactSynonym "Rigid dysarthria" ; oboInOwl:id "HP:0002464" ; a owl:Class ; rdfs:label "Spastic dysarthria" ; rdfs:subClassOf obo:HP_0001257, obo:HP_0001260 . obo:HP_0002465 oboInOwl:hasBroadSynonym "Problems speaking" ; oboInOwl:hasDbXref "UMLS:C1848207", "UMLS:C4280574" ; oboInOwl:hasExactSynonym "Poor speech" ; oboInOwl:hasRelatedSynonym "Difficulty speaking" ; oboInOwl:id "HP:0002465" ; a owl:Class ; rdfs:label "Poor speech" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002470 oboInOwl:hasDbXref "UMLS:C1845029" ; oboInOwl:id "HP:0002470" ; a owl:Class ; rdfs:label "Nonprogressive cerebellar ataxia" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0002472 obo:IAO_0000115 "Reduced size of the cerebral cortex." ; oboInOwl:hasAlternativeId "HP:0006791", "HP:0007151" ; oboInOwl:hasDbXref "UMLS:C1837503" ; oboInOwl:hasExactSynonym "Decreased volume of cerebral cortex" ; oboInOwl:id "HP:0002472" ; a owl:Class ; rdfs:label "Small cerebral cortex" ; rdfs:subClassOf obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002474 obo:IAO_0000115 "A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." ; oboInOwl:hasAlternativeId "HP:0007192" ; oboInOwl:hasBroadSynonym "Communication delay" ; oboInOwl:hasDbXref "SNOMEDCT_US:229734008", "UMLS:C0454641", "UMLS:C1847610", "UMLS:C4280573" ; oboInOwl:hasExactSynonym "Deficit in expressive language" ; oboInOwl:id "HP:0002474" ; a owl:Class ; rdfs:label "Expressive language delay" ; rdfs:subClassOf obo:HP_0000750 . obo:HP_0002475 obo:IAO_0000115 "Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column." ; oboInOwl:hasDbXref "Fyler:4309", "MSH:D008591", "SNOMEDCT_US:203994003", "SNOMEDCT_US:414667000", "UMLS:C0025312" ; oboInOwl:hasExactSynonym "Meningomyelocele", "Spina bifida cystica" ; oboInOwl:id "HP:0002475" ; a owl:Class ; rdfs:comment "Meningomyelocele can result if more than one or two vertebral bodies are affected by spina bifida. The meningomyelocele is usually covered by a thin, vulnerable membrane. Meningomyelocele is generally accompanied by neurological deficits." ; rdfs:label "Myelomeningocele" ; rdfs:subClassOf obo:HP_0002435, obo:HP_0034237 . obo:HP_0002476 obo:IAO_0000115 "The primitive reflexes are a group of behavioural motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant." ; oboInOwl:hasDbXref "UMLS:C1838319" ; oboInOwl:hasExactSynonym "Archaic reflex", "Primitive reflexes" ; oboInOwl:id "HP:0002476" ; a owl:Class ; rdfs:label "Primitive reflex" ; rdfs:subClassOf obo:HP_0031826 . obo:HP_0002478 oboInOwl:hasDbXref "UMLS:C1859736" ; oboInOwl:hasExactSynonym "Progressive spastic quadriparesis" ; oboInOwl:id "HP:0002478" ; a owl:Class ; rdfs:label "Progressive spastic quadriplegia" ; rdfs:subClassOf obo:HP_0002191 . obo:HP_0002480 obo:IAO_0000115 "Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes." ; oboInOwl:hasDbXref "MSH:D006501", "SNOMEDCT_US:13920009", "SNOMEDCT_US:449902003", "UMLS:C0019151" ; oboInOwl:id "HP:0002480" ; a owl:Class ; rdfs:label "Hepatic encephalopathy" ; rdfs:subClassOf obo:HP_0001298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001298 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002483 oboInOwl:hasDbXref "UMLS:C1856507" ; oboInOwl:id "HP:0002483" ; a owl:Class ; rdfs:label "Bulbar signs" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0002486 obo:IAO_0000115 "An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation." ; oboInOwl:hasAlternativeId "HP:0003632", "HP:0003754", "HP:0003792" ; oboInOwl:hasDbXref "MSH:D009222", "SNOMEDCT_US:3434004", "UMLS:C0027125" ; oboInOwl:hasExactSynonym "Delayed relaxation of muscle fibers after contraction", "Delayed relaxation of muscle fibres after contraction" ; oboInOwl:id "HP:0002486" ; a owl:Class ; rdfs:comment "Patients often describe myotonia as stiffness that is worse at the onset of activity and that improves with repeated muscle contractions. Myotonia tends to worsen in cold weather. Myotonia can be elicited by voluntary muscle contraction of by muscle percussion (e.g., by tapping the thenar eminence). During physical examination, myotonia may be elicited by asking the patient to make a tight fist and then quickly open the hand. Myotonia is caused by an abnormality in the muscle membrane, i.e., of the ion channels that control the contraction of muscle fibers." ; rdfs:label "Myotonia" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0002487 obo:IAO_0000115 "Motor hyperactivity with excessive movement of muscles of the body as a whole." ; oboInOwl:hasDbXref "MSH:D006948", "MSH:D013035", "SNOMEDCT_US:44548000", "SNOMEDCT_US:45352006", "UMLS:C0037763", "UMLS:C0424295" ; oboInOwl:hasExactSynonym "Hyperkinesia", "Hyperkinesis", "Muscle spasms" ; oboInOwl:id "HP:0002487" ; a owl:Class ; rdfs:label "Hyperkinetic movements" ; rdfs:subClassOf obo:HP_0100022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002488 obo:IAO_0000115 "A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:32:00Z" ; oboInOwl:hasBroadSynonym "Acute blood cancer" ; oboInOwl:hasDbXref "SNOMEDCT_US:24072005", "SNOMEDCT_US:91855006", "UMLS:C0085669", "UMLS:C4280572" ; oboInOwl:hasExactSynonym "Acute leukaemia", "Acute leukemias" ; oboInOwl:id "HP:0002488" ; a owl:Class ; rdfs:label "Acute leukemia" ; rdfs:subClassOf obo:HP_0001909 . obo:HP_0002490 obo:IAO_0000115 "Increased concentration of lactate in the cerebrospinal fluid." ; oboInOwl:hasDbXref "UMLS:C1167918" ; oboInOwl:hasExactSynonym "Hyperlactatorachia", "Increased CSF lactic acid", "Increased cerebrospinal fluid lactate" ; oboInOwl:id "HP:0002490" ; a owl:Class ; rdfs:label "Increased CSF lactate" ; rdfs:subClassOf obo:HP_0030085 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002491 obo:IAO_0000115 "Spasticity of one or more muscles innervated by the facial nerve." ; oboInOwl:hasAlternativeId "HP:0000313" ; oboInOwl:hasDbXref "UMLS:C1853404", "UMLS:C4280570", "UMLS:C4280571" ; oboInOwl:hasExactSynonym "Spasticity of the facial muscles" ; oboInOwl:hasNarrowSynonym "Increased stiffness of facial muscles", "Increased tone of facial muscles" ; oboInOwl:id "HP:0002491" ; a owl:Class ; rdfs:comment "Spasticity of facial muscles can result in slow oral movements that are imprecise and require a lot of effort." ; rdfs:label "Spasticity of facial muscles" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0001257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001257 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002492 obo:IAO_0000115 "Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord." ; oboInOwl:hasAlternativeId "HP:0006912" ; oboInOwl:hasDbXref "UMLS:C4020852", "UMLS:C4025704" ; oboInOwl:hasRelatedSynonym "Abnormality of the corticospinal tract", "Involvement of the corticospinal pathways" ; oboInOwl:id "HP:0002492" ; a owl:Class ; rdfs:label "Morphological abnormality of the corticospinal tract" ; rdfs:subClassOf obo:HP_0002062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002493 obo:IAO_0000115 "A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs." ; oboInOwl:hasDbXref "UMLS:C1504405", "UMLS:C1839042" ; oboInOwl:hasExactSynonym "Corticospinal tract dysfunction", "Pyramidal tract dysfunction" ; oboInOwl:id "HP:0002493" ; a owl:Class ; rdfs:comment "A functional deficit of the tract that conveys nervous impulses from the motor cortex of the brain to the spinal cord. The corticospinal tract mediates discrete voluntary skilled movements. Clinical features of corticospinal tract dysfunction may include spasticity and weakness, particularly affecting the lower limbs, as well as hyperreflexia, clonus at the ankles and knees, and extensor plantar responses (Babinski response)." ; rdfs:label "Upper motor neuron dysfunction" ; rdfs:subClassOf obo:HP_0011442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001384 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002494 obo:IAO_0000115 "Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements." ; oboInOwl:hasDbXref "SNOMEDCT_US:69020003", "UMLS:C0392188" ; oboInOwl:hasExactSynonym "Abnormal REM sleep" ; oboInOwl:id "HP:0002494" ; a owl:Class ; rdfs:label "Abnormal rapid eye movement sleep" ; rdfs:subClassOf obo:HP_0002360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0042747 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002495 obo:IAO_0000115 "A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient." ; oboInOwl:hasAlternativeId "HP:0006836", "HP:0007116" ; oboInOwl:hasDbXref "SNOMEDCT_US:130980003", "UMLS:C1295585" ; oboInOwl:hasExactSynonym "Decreased vibration sense", "Decreased vibratory sense", "Diminished vibratory sense", "Hypopallesthesia", "Impaired vibratory sensation", "Impaired vibratory sense" ; oboInOwl:id "HP:0002495" ; a owl:Class ; rdfs:comment "Impaired vibratory sensation may suggesti involvement of the posterior column-medial lemniscus pathway, which is responsible for transmitting fine touch, vibration and conscious proprioceptive information from the body to the cerebral cortex." ; rdfs:label "Impaired vibratory sensation" ; rdfs:subClassOf obo:HP_0010831 . obo:HP_0002497 oboInOwl:hasDbXref "MSH:C564815", "UMLS:C1849156" ; oboInOwl:id "HP:0002497" ; a owl:Class ; rdfs:label "Spastic ataxia" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0002500 obo:IAO_0000115 "An abnormality of the cerebral white matter." ; oboInOwl:hasAlternativeId "HP:0200100" ; oboInOwl:hasDbXref "MSH:D049292", "UMLS:C0948163", "UMLS:C4020851" ; oboInOwl:hasExactSynonym "Abnormality of subcortical white matter", "Abnormality of the cerebral white matter", "Cerebral white matter abnormalities", "Leukoaraiosis", "White matter abnormalities", "White matter alterations" ; oboInOwl:hasRelatedSynonym "Cortical white matter abnormalities seen on MRI" ; oboInOwl:id "HP:0002500" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by magnetic resonance imaging, especially with t2 signalling. The cerebral white matter is the region of the central nervous system that consists mostly of glial cells and myelinated axons that interconnect the various regions of the cerebrum and the lower brain centers. It is located in the subcortex." ; rdfs:label "Abnormal cerebral white matter morphology" ; rdfs:subClassOf obo:HP_0010993 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002501 oboInOwl:hasDbXref "UMLS:C1853398" ; oboInOwl:id "HP:0002501" ; a owl:Class ; rdfs:label "Spasticity of pharyngeal muscles" ; rdfs:subClassOf obo:HP_0001257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001257 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000933 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002503 oboInOwl:hasDbXref "UMLS:C1866751" ; oboInOwl:hasExactSynonym "Degeneration of the spinocerebellar tracts", "Spinocerebellar degeneration" ; oboInOwl:id "HP:0002503" ; a owl:Class ; rdfs:label "Spinocerebellar tract degeneration" ; rdfs:subClassOf obo:HP_0003133 . obo:HP_0002504 obo:IAO_0000115 "Deposition of calcium salts within small blood vessels of the brain." ; oboInOwl:hasDbXref "UMLS:C4025703" ; oboInOwl:id "HP:0002504" ; a owl:Class ; rdfs:comment "This finding can be made upon neuropathologic examination." ; rdfs:label "Calcification of the small brain vessels" ; rdfs:subClassOf obo:HP_0009145, obo:HP_0031306 . obo:HP_0002505 obo:IAO_0000115 "Inability to walk in a person who previous had the ability to walk." ; oboInOwl:hasAlternativeId "HP:0006957" ; oboInOwl:hasDbXref "UMLS:C1836843" ; oboInOwl:hasExactSynonym "Loss of ability to walk" ; oboInOwl:id "HP:0002505" ; a owl:Class ; rdfs:label "Loss of ambulation" ; rdfs:subClassOf obo:HP_0002540 . obo:HP_0002506 obo:IAO_0000115 "Diffuse unlocalised atrophy affecting the cerebrum." ; oboInOwl:hasAlternativeId "HP:0006954" ; oboInOwl:hasDbXref "UMLS:C0598275" ; oboInOwl:hasExactSynonym "Cerebral atrophy, diffuse" ; oboInOwl:id "HP:0002506" ; a owl:Class ; rdfs:label "Diffuse cerebral atrophy" ; rdfs:subClassOf obo:HP_0002059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002059 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000635 ] ) ] ] . obo:HP_0002507 obo:IAO_0000115 "A type of holoprosencephaly in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly." ; oboInOwl:hasDbXref "MSH:D016142", "SNOMEDCT_US:253138008", "UMLS:C0751617" ; oboInOwl:id "HP:0002507" ; a owl:Class ; rdfs:label "Semilobar holoprosencephaly" ; rdfs:subClassOf obo:HP_0001360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001360 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002508 obo:IAO_0000115 "A developmental structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord." ; oboInOwl:hasAlternativeId "HP:0006991" ; oboInOwl:hasDbXref "UMLS:C1855677" ; oboInOwl:hasExactSynonym "Brainstem hypoplasia/dysplasia", "Malformation of brainstem structures" ; oboInOwl:id "HP:0002508" ; a owl:Class ; rdfs:label "Brainstem dysplasia" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0002509 oboInOwl:hasDbXref "UMLS:C1838391" ; oboInOwl:hasExactSynonym "Increased muscle tone of arm or leg" ; oboInOwl:id "HP:0002509" ; a owl:Class ; rdfs:label "Limb hypertonia" ; rdfs:subClassOf obo:HP_0001276, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001618 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002510 obo:IAO_0000115 "Spastic paralysis affecting all four limbs." ; oboInOwl:hasAlternativeId "HP:0001280", "HP:0006983" ; oboInOwl:hasDbXref "MSH:D011782", "SNOMEDCT_US:192965001", "UMLS:C0426970" ; oboInOwl:hasExactSynonym "Spastic quadriplegia" ; oboInOwl:id "HP:0002510" ; a owl:Class ; rdfs:label "Spastic tetraplegia" ; rdfs:subClassOf obo:HP_0034353, obo:HP_0100021 . obo:HP_0002511 obo:IAO_0000115 "A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads." ; oboInOwl:hasAlternativeId "HP:0006878", "HP:0007213" ; oboInOwl:hasDbXref "DOID:10652", "MONDO:0004975", "MSH:C536595", "MSH:D000544", "SNOMEDCT_US:230267005", "SNOMEDCT_US:26929004", "UMLS:C0002395", "UMLS:C1863051" ; oboInOwl:hasExactSynonym "Alzheimer disease", "Late-onset form of familial Alzheimer disease" ; oboInOwl:id "HP:0002511" ; a owl:Class ; rdfs:comment "Note that this is a bundled term that refers to a disease rather than to phenotypic features. It is retained for convenience since Alzheimer disease is used for annotation of other diseases (e.g., Down syndrome) as if it were a feature. If possible it is preferable to annotate with the precise phenotypic features." ; rdfs:label "Alzheimer disease" ; rdfs:subClassOf obo:HP_0002011 . obo:HP_0002512 oboInOwl:hasDbXref "SNOMEDCT_US:25816005", "SNOMEDCT_US:5582005", "UMLS:C0270680" ; oboInOwl:id "HP:0002512" ; a owl:Class ; rdfs:label "Brain stem compression" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0002514 obo:IAO_0000115 "The presence of calcium deposition within brain structures." ; oboInOwl:hasAlternativeId "HP:0002502", "HP:0005806", "HP:0006848" ; oboInOwl:hasDbXref "SNOMEDCT_US:17944005", "UMLS:C0270685" ; oboInOwl:hasExactSynonym "Abnormal deposits of calcium in the brain", "Brain calcification", "Intracerebral calcifications", "Intracranial calcification", "Intracranial calcifications" ; oboInOwl:id "HP:0002514" ; a owl:Class ; rdfs:comment "This finding can be demonstrated upon cerebral computer tomography, magnetic resonance imaging, or potentially by standard radiography of the skull." ; rdfs:label "Cerebral calcification" ; rdfs:subClassOf obo:HP_0002060, obo:HP_0010766, obo:HP_0034221 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002515 obo:IAO_0000115 "Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck." ; oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:271706000", "UMLS:C0231712" ; oboInOwl:hasExactSynonym "Waddling gait", "Waddling walk" ; oboInOwl:id "HP:0002515" ; a owl:Class ; rdfs:label "Waddling gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002516 obo:IAO_0000115 "An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." ; oboInOwl:hasDbXref "MSH:D019586", "SNOMEDCT_US:271719001", "UMLS:C0151740" ; oboInOwl:hasExactSynonym "Intracranial hypertension", "Intracranial pressure elevation", "Rise in pressure inside skull" ; oboInOwl:hasRelatedSynonym "Pseudotumor cerebri" ; oboInOwl:id "HP:0002516" ; a owl:Class ; rdfs:comment "Normal values of intracranial pressure in adults are around 7-15 mm Hg in the supine position. The term pseudotumor cerebri (also: idiopathic intracranial hypertension or benign intracranial hypertension) is the presence of increased intracranial pressure in the absence of a brain tumor or other identifiable cause. It should be coded using this term and negations of appropriate other HPO terms. Increased intracranial pressure can damage tissue, contribute to hydrocephalus, cause brain herniation, and restrict blood supply to the brain." ; rdfs:label "Increased intracranial pressure" ; rdfs:subClassOf obo:HP_0012640 . obo:HP_0002518 obo:IAO_0000115 "A structural abnormality of the myelinated axons (white matter) located near the cerebral ventricles." ; oboInOwl:hasDbXref "UMLS:C2673431" ; oboInOwl:hasExactSynonym "Abnormality of the periventricular white matter" ; oboInOwl:hasRelatedSynonym "Periventricular white matter abnormalities" ; oboInOwl:id "HP:0002518" ; a owl:Class ; rdfs:label "Abnormal periventricular white matter morphology" ; rdfs:subClassOf obo:HP_0002352, obo:HP_0002500 . obo:HP_0002519 obo:IAO_0000115 "Fleeting perceptual experiences that occur during the transition from wakefulness to sleep." ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:44780000", "UMLS:C0233773" ; oboInOwl:id "HP:0002519" ; a owl:Class ; rdfs:comment "Hypnagogic hallucinations are visual, auditory and tactile sensations are most commonly reported . Visual phenomena typically consist of kaleidoscopically changing phenomena such as geometric patterns, shapes and light flashes. Images involving animals, people and faces, and scenes also occur and are described as lifelike, highly detailed and colorful. Voices and other sounds (phone, doorbell, music) occur less commonly. They comprise vivid auditory impressions of words or names, people talking, and environmental or animal sounds. Somatic experiences also occur, including bodily distortions, feelings of weightlessness, flying or falling, and a sense of presence in the room." ; rdfs:label "Hypnagogic hallucinations" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0002521 obo:IAO_0000115 "Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG)." ; oboInOwl:hasDbXref "MSH:D013036", "SNOMEDCT_US:28055006", "UMLS:C0684276" ; oboInOwl:hasExactSynonym "Hypsarrhythmia by EEG" ; oboInOwl:id "HP:0002521" ; a owl:Class ; rdfs:label "Hypsarrhythmia" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0002522 obo:IAO_0000115 "Inability to elicit tendon reflexes in the lower limbs." ; oboInOwl:hasDbXref "UMLS:C1856694" ; oboInOwl:hasExactSynonym "Absent lower limb tendon reflexes", "Areflexia in lower limbs", "Areflexia of the lower limbs", "Areflexia, lower limbs" ; oboInOwl:id "HP:0002522" ; a owl:Class ; rdfs:label "Areflexia of lower limbs" ; rdfs:subClassOf obo:HP_0001284, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002524 obo:IAO_0000115 "A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions." ; oboInOwl:hasAlternativeId "HP:0002428", "HP:0002525" ; oboInOwl:hasDbXref "MSH:D002385", "SNOMEDCT_US:46263000", "UMLS:C0007384" ; oboInOwl:id "HP:0002524" ; a owl:Class ; rdfs:comment "Cataplexy is a frequent feature of narcolepsy, a neurologic disorder characterized by excessive daytime sleepiness and manifestations of disrupted rapid eye movement sleep stage." ; rdfs:label "Cataplexy" ; rdfs:subClassOf obo:HP_0011442 . obo:HP_0002526 obo:IAO_0000115 "Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory." ; oboInOwl:hasDbXref "UMLS:C4025702" ; oboInOwl:id "HP:0002526" ; a owl:Class ; rdfs:label "Deficit in nonword repetition" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002527 oboInOwl:hasDbXref "SNOMEDCT_US:161898004", "SNOMEDCT_US:1912002", "UMLS:C0085639" ; oboInOwl:hasExactSynonym "Falls" ; oboInOwl:id "HP:0002527" ; a owl:Class ; rdfs:label "Falls" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002528 obo:IAO_0000115 "Electron-dense granules within double membrane-bound cytoplasmic vacuoles." ; oboInOwl:hasDbXref "SNOMEDCT_US:90506004", "UMLS:C0333454" ; oboInOwl:id "HP:0002528" ; a owl:Class ; rdfs:comment "Degeneration of hippocampal cells characterized by basophilic granules surrounded by a clear zone in hippocampal neurons. Frequently occurs in Alzheimers disease." ; rdfs:label "Granulovacuolar degeneration" ; rdfs:subClassOf obo:HP_0002060, obo:HP_0002180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002529 oboInOwl:hasAlternativeId "HP:0002400" ; oboInOwl:hasDbXref "UMLS:C1850496" ; oboInOwl:hasExactSynonym "Loss of brain cells", "Neuronal loss", "Neuronal loss in CNS" ; oboInOwl:id "HP:0002529" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by neuropathology." ; rdfs:label "Neuronal loss in central nervous system" ; rdfs:subClassOf obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002530 obo:IAO_0000115 "A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles." ; oboInOwl:hasDbXref "UMLS:C1836149" ; oboInOwl:hasExactSynonym "Truncal dystonia" ; oboInOwl:id "HP:0002530" ; a owl:Class ; rdfs:label "Axial dystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0002533 obo:IAO_0000115 "Involuntary flexion or extension of the arms and legs." ; oboInOwl:hasDbXref "SNOMEDCT_US:43029002", "UMLS:C0231471" ; oboInOwl:id "HP:0002533" ; a owl:Class ; rdfs:label "Abnormal posturing" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0002536 obo:IAO_0000115 "An abnormality of the gyri (i.e., the ridges) of the cerebral cortex of the brain." ; oboInOwl:hasAlternativeId "HP:0006900" ; oboInOwl:hasBroadSynonym "Gyral disorganisation", "Gyral disorganization" ; oboInOwl:hasDbXref "UMLS:C1856019" ; oboInOwl:hasExactSynonym "Abnormal gyration", "Cerebral gyral anomalies" ; oboInOwl:id "HP:0002536" ; a owl:Class ; rdfs:label "Abnormal cortical gyration" ; rdfs:subClassOf obo:HP_0002269, obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002538 obo:IAO_0000115 "Any structural abnormality of the cerebral cortex." ; oboInOwl:hasDbXref "UMLS:C4025701" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral cortex" ; oboInOwl:id "HP:0002538" ; a owl:Class ; rdfs:comment "The cerebral cortex constitutes more than half the volume of the human brain and is presumed to be responsible for the neuronal computations underlying complex phenomena, such as perception, thought, language, attention, episodic memory and voluntary movement." ; rdfs:label "Abnormal cerebral cortex morphology" ; rdfs:subClassOf obo:HP_0002060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002539 obo:IAO_0000115 "The presence of developmental dysplasia of the cerebral cortex." ; oboInOwl:hasAlternativeId "HP:0007139" ; oboInOwl:hasDbXref "MSH:D054220", "SNOMEDCT_US:253153000", "UMLS:C0431380" ; oboInOwl:hasExactSynonym "Neocortical dysplasia" ; oboInOwl:id "HP:0002539" ; a owl:Class ; rdfs:label "Cortical dysplasia" ; rdfs:subClassOf obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002540 obo:IAO_0000115 "Incapability to ambulate." ; oboInOwl:hasDbXref "SNOMEDCT_US:282145008", "UMLS:C0560046" ; oboInOwl:hasExactSynonym "Inability to walk", "Non-ambulatory" ; oboInOwl:id "HP:0002540" ; a owl:Class ; rdfs:label "Inability to walk" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0002542 obo:IAO_0000115 "Neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus." ; oboInOwl:hasAlternativeId "HP:0005683" ; oboInOwl:hasDbXref "MSH:D009849", "SNOMEDCT_US:67761004", "UMLS:C0028968" ; oboInOwl:hasExactSynonym "Olivopontocerebellar degeneration" ; oboInOwl:id "HP:0002542" ; a owl:Class ; rdfs:label "Olivopontocerebellar atrophy" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0002544 obo:IAO_0000115 "A form of torticollis in which the head is drawn back, either due to a permanent contractures of neck extensor muscles, or to a spasmodic contracture." ; oboInOwl:hasDbXref "UMLS:C3887667" ; oboInOwl:id "HP:0002544" ; a owl:Class ; rdfs:comment "Retrocollis is a spasmodic form of torticollis in which the head is drawn back." ; rdfs:label "Retrocollis" ; rdfs:subClassOf obo:HP_0000473 . obo:HP_0002545 obo:IAO_0000115 "Patchy loss of myelin from nerve fibers in the central nervous system." ; oboInOwl:hasDbXref "UMLS:C1857638" ; oboInOwl:id "HP:0002545" ; a owl:Class ; rdfs:label "Patchy demyelination of subcortical white matter" ; rdfs:subClassOf obo:HP_0007305 . obo:HP_0002546 oboInOwl:hasDbXref "UMLS:C1838027" ; oboInOwl:hasExactSynonym "Incomprehensible speech" ; oboInOwl:id "HP:0002546" ; a owl:Class ; rdfs:label "Incomprehensible speech" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0002548 obo:IAO_0000115 "Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication." ; oboInOwl:hasDbXref "UMLS:C1846868" ; oboInOwl:hasExactSynonym "Parkinsonism with favourable response to dopaminergic medication" ; oboInOwl:hasRelatedSynonym "Favorable response to levodopa", "Favourable response to levodopa" ; oboInOwl:id "HP:0002548" ; a owl:Class ; rdfs:label "Parkinsonism with favorable response to dopaminergic medication" ; rdfs:subClassOf obo:HP_0001300 . obo:HP_0002549 obo:IAO_0000115 "Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory" ; oboInOwl:hasDbXref "UMLS:C1847609" ; oboInOwl:hasExactSynonym "Deficit in non-word repetition", "Impaired non-word repetition" ; oboInOwl:id "HP:0002549" ; a owl:Class ; rdfs:label "Deficit in phonologic short-term memory" ; rdfs:subClassOf obo:HP_0033687 . obo:HP_0002550 obo:IAO_0000115 "Absence of facial hair." ; oboInOwl:hasDbXref "UMLS:C1848192" ; oboInOwl:hasExactSynonym "Absent facial hair" ; oboInOwl:id "HP:0002550" ; a owl:Class ; rdfs:label "Absent facial hair" ; rdfs:subClassOf obo:HP_0002298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010171 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002552 obo:IAO_0000115 "Developmental dysplasia of the hair." ; oboInOwl:hasAlternativeId "HP:0004515" ; oboInOwl:hasDbXref "UMLS:C4020850", "UMLS:C4025700" ; oboInOwl:hasRelatedSynonym "Generalised trichodysplasia", "Generalized trichodysplasia" ; oboInOwl:id "HP:0002552" ; a owl:Class ; rdfs:label "Trichodysplasia" ; rdfs:subClassOf obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002553 obo:IAO_0000115 "Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape." ; oboInOwl:hasAlternativeId "HP:0001584", "HP:0004533", "HP:0007681", "HP:0007804", "HP:0008505" ; oboInOwl:hasDbXref "UMLS:C1868571", "UMLS:C4020849" ; oboInOwl:hasExactSynonym "Arched eyebrows", "Broad, arched eyebrows", "High, rounded eyebrows", "High-arched eyebrows", "Highly arched eyebrow", "Thick, flared eyebrows" ; oboInOwl:hasRelatedSynonym "Bowed and upward slanting eyebrows", "High arched eyebrows" ; oboInOwl:id "HP:0002553" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Most eyebrows have some arch with downturning medially and laterally." ; rdfs:label "Highly arched eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001594 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002555 obo:IAO_0000115 "Absence of pubic hair." ; oboInOwl:hasAlternativeId "HP:0004537", "HP:0004556" ; oboInOwl:hasDbXref "UMLS:C1859391" ; oboInOwl:hasExactSynonym "Absent pubic hair" ; oboInOwl:id "HP:0002555" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent pubic hair" ; rdfs:subClassOf obo:HP_0002298, obo:HP_0100133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013698 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002557 obo:IAO_0000115 "Underdevelopment of the nipple." ; oboInOwl:hasAlternativeId "HP:0002560", "HP:0003188", "HP:0006652" ; oboInOwl:hasDbXref "SNOMEDCT_US:268290005", "UMLS:C0432355" ; oboInOwl:hasExactSynonym "Nipple hypoplasia", "Small nipples" ; oboInOwl:id "HP:0002557" ; a owl:Class ; rdfs:label "Hypoplastic nipples" ; rdfs:subClassOf obo:HP_0006709 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002558 obo:IAO_0000115 "Presence of more than two nipples." ; oboInOwl:hasAlternativeId "HP:0002559" ; oboInOwl:hasDbXref "Fyler:4234", "MSH:C562557", "SNOMEDCT_US:50956007", "UMLS:C0266011" ; oboInOwl:hasExactSynonym "Accessory nipple", "Increased nipple number", "accessory mamilla" ; oboInOwl:hasRelatedSynonym "Accessory nipples", "Supernumerary nipples", "accessory mamillas" ; oboInOwl:id "HP:0002558" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Supernumerary nipple" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002561 obo:IAO_0000115 "Congenital failure to develop, and absence of, the nipple." ; oboInOwl:hasDbXref "SNOMEDCT_US:248820000", "UMLS:C0425795" ; oboInOwl:hasExactSynonym "Absent nipple", "Absent nipples", "Athelia" ; oboInOwl:id "HP:0002561" ; a owl:Class ; rdfs:comment "This finding can be unilateral or bilateral." ; rdfs:label "Absent nipple" ; rdfs:subClassOf obo:HP_0006709 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002562 obo:IAO_0000115 "Placement of the nipples at a lower than normal location." ; oboInOwl:hasDbXref "UMLS:C1836933" ; oboInOwl:hasExactSynonym "Low-set nipples" ; oboInOwl:id "HP:0002562" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Low-set nipples" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001476 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002563 obo:IAO_0000115 "Presence of a thickened, fibrotic pericardium that forms a non-compliant shell around the heart, and resulting from chronic inflammation of the pericardium." ; oboInOwl:hasDbXref "MSH:D010494", "SNOMEDCT_US:85598007", "UMLS:C0031048" ; oboInOwl:id "HP:0002563" ; a owl:Class ; rdfs:label "Constrictive pericarditis" ; rdfs:subClassOf obo:HP_0001701 . obo:HP_0002564 obo:IAO_0100001 "HP:0030680" ; oboInOwl:id "HP:0002564" ; a owl:Class ; rdfs:label "obsolete Malformation of the heart and great vessels" ; owl:deprecated true . obo:HP_0002566 obo:IAO_0000115 "An abnormality of the intestinal rotation and fixation that normally occurs during the development of the gut. This can lead to volvulus, or twisting of the intestine that causes obstruction and necrosis." ; oboInOwl:hasAlternativeId "HP:0002026" ; oboInOwl:hasDbXref "MEDDRA:10064024", "MSH:C562456", "SNOMEDCT_US:253789002", "SNOMEDCT_US:29980002", "SNOMEDCT_US:48641006", "UMLS:C0221210" ; oboInOwl:hasExactSynonym "Malrotation" ; oboInOwl:hasRelatedSynonym "Gut malrotation" ; oboInOwl:id "HP:0002566" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Intestinal malrotation" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002570 obo:IAO_0000115 "Greater than normal amounts of fat in the feces. This is a result of malabsorption of lipids in the small intestine and results in frothy foul-smelling fecal matter that floats." ; oboInOwl:hasDbXref "MSH:D045602", "SNOMEDCT_US:27868004", "SNOMEDCT_US:66187002", "UMLS:C0038238" ; oboInOwl:hasExactSynonym "Fat in faeces", "Fat in feces", "Fatty stool", "Greasy stools" ; oboInOwl:id "HP:0002570" ; a owl:Class ; rdfs:label "Steatorrhea" ; rdfs:subClassOf obo:HP_0002630 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001988 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002571 obo:IAO_0000115 "A disorder of esophageal motility characterized by the inability of the lower esophageal sphincter to relax during swallowing and by inadequate or lacking peristalsis in the lower half of the body of the esophagus." ; oboInOwl:hasDbXref "MEDDRA:10030136", "MSH:D004931", "SNOMEDCT_US:45564002", "UMLS:C0014848" ; oboInOwl:hasExactSynonym "Achalasia of the esophagus", "Achalasia of the oesophagus" ; oboInOwl:id "HP:0002571" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Achalasia may lead to regurgitation of food, chest pain, cough, and difficulty swallowing." ; rdfs:label "Achalasia" ; rdfs:subClassOf obo:HP_0031857 . obo:HP_0002572 obo:IAO_0000115 "Paroxysmal, recurrent episodes of vomiting." ; oboInOwl:hasDbXref "UMLS:C1838993", "UMLS:C1857202" ; oboInOwl:hasExactSynonym "Episodic vomiting" ; oboInOwl:hasRelatedSynonym "Frequent vomiting" ; oboInOwl:id "HP:0002572" ; a owl:Class ; rdfs:label "Episodic vomiting" ; rdfs:subClassOf obo:HP_0002013 . obo:HP_0002573 obo:IAO_0000115 "The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus." ; oboInOwl:hasAlternativeId "HP:0002255", "HP:0002609" ; oboInOwl:hasDbXref "MSH:D006471", "SNOMEDCT_US:236068001", "SNOMEDCT_US:405729008", "UMLS:C0018932" ; oboInOwl:hasExactSynonym "Rectal bleeding" ; oboInOwl:hasRelatedSynonym "Recurrent rectal bleeding" ; oboInOwl:id "HP:0002573" ; a owl:Class ; rdfs:comment "Bright red blood in stool, most frequentoly caused by hemorrhoids or diverticulosis." ; rdfs:label "Hematochezia" ; rdfs:subClassOf obo:HP_0002239, obo:HP_0025085 . obo:HP_0002574 obo:IAO_0000115 "An intermittent form of abdominal pain." ; oboInOwl:hasDbXref "UMLS:C0262527", "UMLS:C3808022" ; oboInOwl:hasRelatedSynonym "Intermittent abdominal pain" ; oboInOwl:id "HP:0002574" ; a owl:Class ; rdfs:label "Episodic abdominal pain" ; rdfs:subClassOf obo:HP_0002027, obo:HP_0032148 . obo:HP_0002575 obo:IAO_0000115 "An abnormal connection (fistula) between the esophagus and the trachea." ; oboInOwl:hasBroadSynonym "Abnormal connection between trachea and esophagus", "Abnormal connection between trachea and oesophagus" ; oboInOwl:hasDbXref "Fyler:4202", "MEDDRA:10044310", "MSH:D014138", "SNOMEDCT_US:95435007", "UMLS:C0040588" ; oboInOwl:id "HP:0002575" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Tracheoesophageal fistula" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0002778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:MPATH_70 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002576 obo:IAO_0000115 "An abnormality of the intestine in which part of the intestine invaginates (telescopes) into another part of the intestine." ; oboInOwl:hasDbXref "MEDDRA:10022863", "MSH:D007443", "SNOMEDCT_US:35327006", "SNOMEDCT_US:49723003", "UMLS:C0021933" ; oboInOwl:id "HP:0002576" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Intussusception can lead to intestinal obstruction as well as to the interruption of the blood supply to the intestine. It can affect small or large bowel." ; rdfs:label "Intussusception" ; rdfs:subClassOf obo:HP_0002242 . obo:HP_0002577 obo:IAO_0000115 "An abnormality of the stomach." ; oboInOwl:hasDbXref "UMLS:C4025699" ; oboInOwl:hasExactSynonym "Abnormality of the stomach" ; oboInOwl:id "HP:0002577" ; a owl:Class ; rdfs:comment "The stomach is the hollow, muscular organ of the gastrointestinal tract between the esophagus and the small intestine." ; rdfs:label "Abnormal stomach morphology" ; rdfs:subClassOf obo:HP_0012718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002578 obo:IAO_0000115 "Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction." ; oboInOwl:hasDbXref "MSH:D018589", "SNOMEDCT_US:196753007", "SNOMEDCT_US:235675006", "UMLS:C0152020" ; oboInOwl:hasExactSynonym "Delayed gastric emptying" ; oboInOwl:id "HP:0002578" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gastroparesis" ; rdfs:subClassOf obo:HP_0011804, obo:HP_0025032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008856 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002579 obo:IAO_0000115 "Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes." ; oboInOwl:hasDbXref "UMLS:C1836923" ; oboInOwl:hasExactSynonym "GI dysmotility" ; oboInOwl:id "HP:0002579" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gastrointestinal dysmotility" ; rdfs:subClassOf obo:HP_0030895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0014831 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002580 obo:IAO_0000115 "Abnormal twisting of a portion of intestine around itself or around a stalk of mesentery tissue." ; oboInOwl:hasDbXref "MSH:D045822", "SNOMEDCT_US:90738007", "SNOMEDCT_US:9707006", "UMLS:C0042961" ; oboInOwl:id "HP:0002580" ; a owl:Class ; rdfs:comment "Volvulus can lead to intestinal obstruction and ischemia." ; rdfs:label "Volvulus" ; rdfs:subClassOf obo:HP_0002242 . obo:HP_0002582 obo:IAO_0000115 "Atrophic gastritis (AG) is a histopathological entity that is characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue." ; oboInOwl:hasDbXref "MSH:D005757", "SNOMEDCT_US:84568007", "UMLS:C0017154" ; oboInOwl:hasExactSynonym "Chronic atrophic gastritis" ; oboInOwl:id "HP:0002582" ; a owl:Class ; rdfs:comment "Atrophy of the gastric mucosa is the endpoint of chronic processes, such as chronic gastritis associated with Helicobacter pylori (H. pylori) infection, other unidentified environmental factors, and autoimmunity directed against gastric glandular cells." ; rdfs:label "Atrophic gastritis" ; rdfs:subClassOf obo:HP_0005263 . obo:HP_0002583 obo:IAO_0000115 "Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases." ; oboInOwl:hasDbXref "MSH:D003092", "SNOMEDCT_US:64226004", "UMLS:C0009319" ; oboInOwl:id "HP:0002583" ; a owl:Class ; rdfs:label "Colitis" ; rdfs:subClassOf obo:HP_0002037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002584 obo:IAO_0000115 "Bleeding from the intestines." ; oboInOwl:hasDbXref "SNOMEDCT_US:712510007", "UMLS:C0267373" ; oboInOwl:hasExactSynonym "Intestinal bleeding", "Intestinal haemorrhage", "Intestinal hemorrhage" ; oboInOwl:id "HP:0002584" ; a owl:Class ; rdfs:label "Intestinal bleeding" ; rdfs:subClassOf obo:HP_0002239, obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002585 obo:IAO_0000115 "An abnormality of the peritoneum." ; oboInOwl:hasDbXref "UMLS:C4025698" ; oboInOwl:hasExactSynonym "Abnormality of the peritoneum" ; oboInOwl:id "HP:0002585" ; a owl:Class ; rdfs:comment "The peritoneum is the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs." ; rdfs:label "Abnormal peritoneum morphology" ; rdfs:subClassOf obo:HP_0002012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002586 obo:IAO_0000115 "Inflammation of the peritoneum." ; oboInOwl:hasAlternativeId "HP:0100591" ; oboInOwl:hasDbXref "MSH:D010538", "SNOMEDCT_US:48661000", "UMLS:C0031154" ; oboInOwl:hasExactSynonym "Inflammation of the peritoneum" ; oboInOwl:id "HP:0002586" ; a owl:Class ; rdfs:label "Peritonitis" ; rdfs:subClassOf obo:HP_0002585, obo:HP_0045073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002587 obo:IAO_0000115 "Vomiting that ejects the gastric contents with great force." ; oboInOwl:hasDbXref "SNOMEDCT_US:8579004", "UMLS:C0221151" ; oboInOwl:hasExactSynonym "Projectile vomiting" ; oboInOwl:id "HP:0002587" ; a owl:Class ; rdfs:label "Projectile vomiting" ; rdfs:subClassOf obo:HP_0002013 . obo:HP_0002588 obo:IAO_0000115 "An erosion of the mucous membrane in a portion of the duodenum." ; oboInOwl:hasDbXref "MEDDRA:10013836", "MSH:D004381", "SNOMEDCT_US:367474008", "SNOMEDCT_US:51868009", "UMLS:C0013295" ; oboInOwl:id "HP:0002588" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Duodenal ulcer" ; rdfs:subClassOf obo:HP_0002246, obo:HP_0034274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_579 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002589 oboInOwl:hasDbXref "UMLS:C4025697" ; oboInOwl:hasExactSynonym "GI atresia" ; oboInOwl:id "HP:0002589" ; a owl:Class ; rdfs:label "Gastrointestinal atresia" ; rdfs:subClassOf obo:HP_0012718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002590 oboInOwl:hasDbXref "MSH:D007418", "SNOMEDCT_US:55525008", "UMLS:C0030446" ; oboInOwl:id "HP:0002590" ; a owl:Class ; rdfs:label "Paralytic ileus" ; rdfs:subClassOf obo:HP_0002595 . obo:HP_0002591 obo:IAO_0000115 "A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat." ; oboInOwl:hasAlternativeId "HP:0000724", "HP:0002042" ; oboInOwl:hasDbXref "MSH:D006963", "SNOMEDCT_US:267023007", "SNOMEDCT_US:58424009", "SNOMEDCT_US:72405004", "UMLS:C0020505", "UMLS:C0232461" ; oboInOwl:hasExactSynonym "Hyperphagia", "Voracious appetite" ; oboInOwl:hasRelatedSynonym "Increased appetite" ; oboInOwl:id "HP:0002591" ; a owl:Class ; rdfs:label "Polyphagia" ; rdfs:subClassOf obo:HP_0100738 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000063 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002592 obo:IAO_0000115 "An ulcer, that is, an erosion of an area of the gastric mucous membrane." ; oboInOwl:hasDbXref "MEDDRA:10017822", "MSH:D013276", "SNOMEDCT_US:397825006", "UMLS:C0038358" ; oboInOwl:hasExactSynonym "Stomach ulcer" ; oboInOwl:id "HP:0002592" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The presence of a mucosal erosion equal to or greater than 0.5 cm." ; rdfs:label "Gastric ulcer" ; rdfs:subClassOf obo:HP_0004295, obo:HP_0004398 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_579 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001199 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002593 obo:IAO_0000115 "Angiectasia of lymph vessels (i.e., dilatation of lymphatic vessels) in the intestines." ; oboInOwl:hasDbXref "MSH:D008201", "SNOMEDCT_US:197260007", "UMLS:C0024215" ; oboInOwl:id "HP:0002593" ; a owl:Class ; rdfs:label "Intestinal lymphangiectasia" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0031842 . obo:HP_0002594 obo:IAO_0000115 "Hypoplasia of the pancreas." ; oboInOwl:hasAlternativeId "HP:0005221" ; oboInOwl:hasDbXref "SNOMEDCT_US:68591005", "UMLS:C0266267" ; oboInOwl:hasExactSynonym "Hypoplastic pancreas", "Underdeveloped pancreas" ; oboInOwl:id "HP:0002594" ; a owl:Class ; rdfs:comment "Hypoplasia is defined in MPATH as resulting in a small organ or structure owing to failure to develop to normal size." ; rdfs:label "Pancreatic hypoplasia" ; rdfs:subClassOf obo:HP_0100800 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002595 obo:IAO_0000115 "Acute obstruction of the intestines preventing passage of the contents of the intestines." ; oboInOwl:hasDbXref "MEDDRA:10021328", "MSH:D045823", "UMLS:C1258215" ; oboInOwl:hasExactSynonym "Gastrointestinal atony" ; oboInOwl:id "HP:0002595" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ileus" ; rdfs:subClassOf obo:HP_0002579, obo:HP_0005214 . obo:HP_0002597 obo:IAO_0000115 "An abnormality of the vasculature." ; oboInOwl:hasDbXref "UMLS:C0241657" ; oboInOwl:hasExactSynonym "Abnormality of blood vessels", "Abnormality of the vasculature", "Vascular abnormalities" ; oboInOwl:id "HP:0002597" ; a owl:Class ; rdfs:label "Abnormality of the vasculature" ; rdfs:subClassOf obo:HP_0001626 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002049 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002599 obo:IAO_0000115 "A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction." ; oboInOwl:hasDbXref "UMLS:C1608410" ; oboInOwl:id "HP:0002599" ; a owl:Class ; rdfs:comment """Titubation often accompanies midline cerebellar lesions. The 3-4 per second frequency of titubation is faster than the head nodding/bobbing that can be seen with thalamic lesions. The original description of head titubation in 1899 by Gowers (see PMID:4821687) was: As the disease progresses, some jerky irregularity develops in the movement of the neck and head so that the head presents slight movements, sometimes like an irregular tremor, sometimes simulating chorea.""" ; rdfs:label "Head titubation" ; rdfs:subClassOf obo:HP_0002346, obo:HP_0002457, obo:HP_0030187 . obo:HP_0002600 obo:IAO_0000115 "Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping." ; oboInOwl:hasAlternativeId "HP:0006861" ; oboInOwl:hasDbXref "UMLS:C1834696" ; oboInOwl:hasExactSynonym "Hyporeflexia in lower limbs", "Hyporeflexia of the lower limbs", "Hyporeflexia, lower limbs", "Hyporeflexia/areflexia in lower limbs" ; oboInOwl:id "HP:0002600" ; a owl:Class ; rdfs:comment "Reflexes are sensorimotor arcs that require some type of sensory (afferent) signal, and some motor response. While the simplest of reflexes involve direct synapse between the sensory fiber and the motor neuron (monosynaptic), many reflexes have several neurons interposed (polysynaptic reflexes). Hyporeflexia can result from a defect anywhere in this chain." ; rdfs:label "Hyporeflexia of lower limbs" ; rdfs:subClassOf obo:HP_0001265, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002601 oboInOwl:hasDbXref "UMLS:C4025696" ; oboInOwl:id "HP:0002601" ; a owl:Class ; rdfs:label "Paresis of extensor muscles of the big toe" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0002460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000311 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002604 obo:IAO_0000115 "Telangiectasia affecting the gastrointestinal tract." ; oboInOwl:hasDbXref "UMLS:C1619711" ; oboInOwl:hasExactSynonym "GI telangiectasia", "Small, enlarged blood vessels near skin" ; oboInOwl:id "HP:0002604" ; a owl:Class ; rdfs:comment "Telangiectasia affecting stomach, duodenum, small bowel, and/or colon." ; rdfs:label "Gastrointestinal telangiectasia" ; rdfs:subClassOf obo:HP_0004296, obo:HP_0100579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002605 obo:IAO_0000115 "The presence of cell death (necrosis) affecting the liver." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:32:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:87248009", "UMLS:C0151798" ; oboInOwl:id "HP:0002605" ; a owl:Class ; rdfs:label "Hepatic necrosis" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002607 obo:IAO_0000115 "Involuntary fecal soiling in adults and children who have usually already been toilet trained." ; oboInOwl:hasAlternativeId "HP:0007147" ; oboInOwl:hasDbXref "MSH:D005242", "SNOMEDCT_US:72042002", "UMLS:C0015732" ; oboInOwl:hasExactSynonym "Anal incontinence", "Faecal incontinence", "Fecal incontinence", "Loss of bowel control" ; oboInOwl:id "HP:0002607" ; a owl:Class ; rdfs:label "Bowel incontinence" ; rdfs:subClassOf obo:HP_0012700, obo:HP_0031064 . obo:HP_0002608 obo:IAO_0000115 "Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases." ; oboInOwl:hasDbXref "MSH:D002446", "SNOMEDCT_US:396331005", "UMLS:C0007570" ; oboInOwl:hasExactSynonym "Celiac disease", "Celiac sprue", "Coeliac disease", "Coeliac sprue" ; oboInOwl:id "HP:0002608" ; a owl:Class ; rdfs:label "Celiac disease" ; rdfs:subClassOf obo:HP_0002244, obo:HP_0100326 . obo:HP_0002611 oboInOwl:hasDbXref "UMLS:C0860204" ; oboInOwl:id "HP:0002611" ; a owl:Class ; rdfs:label "Cholestatic liver disease" ; rdfs:subClassOf obo:HP_0001396 . obo:HP_0002612 obo:IAO_0000115 "The presence of fibrosis of that part of the liver with congenital onset." ; oboInOwl:hasDbXref "MSH:C562378", "SNOMEDCT_US:79607001", "UMLS:C0009714" ; oboInOwl:hasExactSynonym "Congenital liver fibrosis", "Excessive buildup of connective tissue and scarring of liver at birth" ; oboInOwl:id "HP:0002612" ; a owl:Class ; rdfs:comment "Congenital hepatic fibrosis is characterized by enlarged portal tracts with extensive fibrosis and numerous bile ductules that communicate with the bile tree. The affected area tends to be sharply demarcated from normal liver parenchyma and does not display regenerative nodules (which distinguished the condition from cirrhosis)." ; rdfs:label "Congenital hepatic fibrosis" ; rdfs:subClassOf obo:HP_0001395 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001395 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0003577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002613 obo:IAO_0000115 "Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease." ; oboInOwl:hasDbXref "MSH:D008105", "SNOMEDCT_US:1761006", "SNOMEDCT_US:31712002", "UMLS:C0008312", "UMLS:C0023892" ; oboInOwl:hasRelatedSynonym "Primary biliary cirrhosis" ; oboInOwl:id "HP:0002613" ; a owl:Class ; rdfs:label "Biliary cirrhosis" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0002614 obo:IAO_0000115 "A type of hepatic necrosis that is concentrated around the necrosis of hepatocytes localized around the intrahepatic branch of portal vein." ; oboInOwl:hasDbXref "UMLS:C0546389" ; oboInOwl:id "HP:0002614" ; a owl:Class ; rdfs:label "Hepatic periportal necrosis" ; rdfs:subClassOf obo:HP_0002605 . obo:HP_0002615 obo:IAO_0000115 "Low Blood Pressure, vascular hypotension." ; oboInOwl:hasAlternativeId "HP:0005127", "HP:0006701" ; oboInOwl:hasDbXref "MSH:D007022", "SNOMEDCT_US:45007003", "UMLS:C0020649" ; oboInOwl:hasExactSynonym "Arterial hypotension", "Low blood pressure" ; oboInOwl:id "HP:0002615" ; a owl:Class ; rdfs:label "Hypotension" ; rdfs:subClassOf obo:HP_0030972 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001575 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0002616 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the aortic root." ; oboInOwl:hasAlternativeId "HP:0002631", "HP:0004750", "HP:0005125" ; oboInOwl:hasBroadSynonym "Aortic root dilatation" ; oboInOwl:hasDbXref "SNOMEDCT_US:251036003", "UMLS:C0238669" ; oboInOwl:hasExactSynonym "Bulge in wall of root of large artery that carries blood away from heart", "Increased aortic root diameter" ; oboInOwl:id "HP:0002616" ; a owl:Class ; rdfs:label "Aortic root aneurysm" ; rdfs:subClassOf obo:HP_0012727 . obo:HP_0002617 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart." ; oboInOwl:hasDbXref "Fyler:2399", "MSH:D000783", "SNOMEDCT_US:432119003", "SNOMEDCT_US:85659009", "UMLS:C0002940", "UMLS:C4020848" ; oboInOwl:hasExactSynonym "Aneurysmal dilatation", "Wider than typical opening or gap" ; oboInOwl:hasNarrowSynonym "Aneurysm", "Aneurysms" ; oboInOwl:hasRelatedSynonym "Aneurysmal disease" ; oboInOwl:id "HP:0002617" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Vascular dilatation" ; rdfs:subClassOf obo:HP_0033353 . obo:HP_0002619 obo:IAO_0000115 "Enlarged and tortuous veins." ; oboInOwl:hasDbXref "MSH:D014648", "SNOMEDCT_US:128060009", "SNOMEDCT_US:12856003", "SNOMEDCT_US:399989005", "UMLS:C0042345" ; oboInOwl:id "HP:0002619" ; a owl:Class ; rdfs:label "Varicose veins" ; rdfs:subClassOf obo:HP_0005293 . obo:HP_0002621 obo:IAO_0000115 "A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow." ; oboInOwl:hasBroadSynonym "Plaque build-up in arteries" ; oboInOwl:hasDbXref "MSH:D050197", "SNOMEDCT_US:38716007", "UMLS:C0004153", "UMLS:C4280569" ; oboInOwl:hasExactSynonym "Atherosclerotic cardiovascular disease", "Narrowing and hardening of arteries" ; oboInOwl:id "HP:0002621" ; a owl:Class ; rdfs:comment "Strictly speaking, atherosclerosis is a specific type of arteriosclerosis ('hardening of the arteries'), although the terms are sometimes used interchangeably in clinical jargon." ; rdfs:label "Atherosclerosis" ; rdfs:subClassOf obo:HP_0002634 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_28 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002622 obo:IAO_0100001 "HP:0002647" ; oboInOwl:id "HP:0002622" ; a owl:Class ; rdfs:label "obsolete Dissecting aortic dilatation" ; owl:deprecated true . obo:HP_0002623 obo:IAO_0000115 "An overriding aorta is a congenital heart defect where the aorta is positioned directly over a ventricular septal defect, instead of over the left ventricle. The result is that the aorta receives some blood from the right ventricle, which reduces the amount of oxygen in the blood. It is one of the four conditions of the Tetralogy of Fallot. The aortic root can be displaced toward the front (anteriorly) or directly above the septal defect, but it is always abnormally located to the right of the root of the pulmonary artery. The degree of override is quite variable, with 5-95% of the valve being connected to the right ventricle." ; oboInOwl:hasDbXref "Fyler:1432", "SNOMEDCT_US:63934006", "UMLS:C0011818", "UMLS:C0265886" ; oboInOwl:hasExactSynonym "Dextroposition of aorta", "Overriding aortic valve" ; oboInOwl:id "HP:0002623" ; a owl:Class ; rdfs:label "Overriding aorta" ; rdfs:subClassOf obo:HP_0001679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001590 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000947 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004666 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002624 obo:IAO_0000115 "An anomaly of vein." ; oboInOwl:hasDbXref "UMLS:C0241665" ; oboInOwl:hasExactSynonym "Abnormal vein", "Venous abnormality" ; oboInOwl:id "HP:0002624" ; a owl:Class ; rdfs:label "Abnormal venous morphology" ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002625 obo:IAO_0000115 "Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected." ; oboInOwl:hasDbXref "MSH:D020246", "SNOMEDCT_US:128053003", "UMLS:C0149871" ; oboInOwl:hasExactSynonym "Blood clot in a deep vein", "Deep vein thrombosis", "Multiple deep venous thrombosis" ; oboInOwl:id "HP:0002625" ; a owl:Class ; rdfs:label "Deep venous thrombosis" ; rdfs:subClassOf obo:HP_0004936 . obo:HP_0002626 obo:IAO_0000115 "Elongated and tortuous mesenteric veins, which comprise the inferior mesenteric vein and the superior mesenteric vein." ; oboInOwl:hasDbXref "UMLS:C1857692" ; oboInOwl:hasExactSynonym "Venous varicosities of coeliac and mesenteric vessels" ; oboInOwl:id "HP:0002626" ; a owl:Class ; rdfs:label "Venous varicosities of celiac and mesenteric vessels" ; rdfs:subClassOf obo:HP_0002619 . obo:HP_0002627 obo:IAO_0000115 "The aortic arch crosses the right mainstem bronchus and not the left mainstem bronchus, but does not result in the creation of a vascular ring. The first branch is the left brachiocephalic artery which divides into the left carotid artery and left subclavian artery, the second branch is the right carotid artery, the third branch is the right subclavian artery." ; oboInOwl:hasDbXref "UMLS:C4025695" ; oboInOwl:id "HP:0002627" ; a owl:Class ; rdfs:label "Right aortic arch with mirror image branching" ; rdfs:subClassOf obo:HP_0012020 . obo:HP_0002629 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract." ; oboInOwl:hasDbXref "UMLS:C0744321" ; oboInOwl:hasExactSynonym "GI arteriovenous malformation" ; oboInOwl:id "HP:0002629" ; a owl:Class ; rdfs:label "Gastrointestinal arteriovenous malformation" ; rdfs:subClassOf obo:HP_0004296, obo:HP_0100026 . obo:HP_0002630 obo:IAO_0000115 "Abnormality of the absorption of fat from the gastrointestinal tract." ; oboInOwl:hasDbXref "SNOMEDCT_US:197494007", "UMLS:C0554103" ; oboInOwl:id "HP:0002630" ; a owl:Class ; rdfs:label "Fat malabsorption" ; rdfs:subClassOf obo:HP_0002024, obo:HP_0002244 . obo:HP_0002631 obo:IAO_0100001 "HP:0002616" ; oboInOwl:id "HP:0002631" ; a owl:Class ; rdfs:label "obsolete Dilatation of ascending aorta" ; owl:deprecated true . obo:HP_0002632 oboInOwl:hasDbXref "UMLS:C1866500" ; oboInOwl:hasExactSynonym "Low-to-normal BP", "Low-to-normal blood pressure" ; oboInOwl:id "HP:0002632" ; a owl:Class ; rdfs:label "Low-to-normal blood pressure" ; rdfs:subClassOf obo:HP_0002615 . obo:HP_0002633 obo:IAO_0000115 "Inflammation of blood vessel." ; oboInOwl:hasDbXref "MSH:D014657", "SNOMEDCT_US:31996006", "UMLS:C0042384" ; oboInOwl:hasExactSynonym "Angiitis", "Inflammation of blood vessel" ; oboInOwl:id "HP:0002633" ; a owl:Class ; rdfs:label "Vasculitis" ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_201 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002634 obo:IAO_0000115 "Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity." ; oboInOwl:hasBroadSynonym "Hardened artery wall" ; oboInOwl:hasDbXref "MSH:D001161", "SNOMEDCT_US:107671003", "SNOMEDCT_US:28960008", "SNOMEDCT_US:72092001", "UMLS:C0003850", "UMLS:C4280568" ; oboInOwl:id "HP:0002634" ; a owl:Class ; rdfs:comment "Although arteriosclerosis and atherosclerosis are often used as if they were synonyms, they are not. Atherosclerosis is the most common type of arteriosclerosis, and is caused by plaque building up in the vessel, which in turn causes sclerosis, increased stiffness, and loss of elasticity of the affected arteries." ; rdfs:label "Arteriosclerosis" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002635 obo:IAO_0000115 "In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion." ; oboInOwl:hasDbXref "MSH:D050197", "SNOMEDCT_US:38716007", "UMLS:C0004153" ; oboInOwl:hasRelatedSynonym "Atheromatosis" ; oboInOwl:id "HP:0002635" ; a owl:Class ; rdfs:label "Type IV atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0002636 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in an artery that originates from the abdominal aorta." ; oboInOwl:hasDbXref "UMLS:C4025694" ; oboInOwl:hasNarrowSynonym "Aneurysm of an abdominal artery" ; oboInOwl:id "HP:0002636" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of an abdominal artery" ; rdfs:subClassOf obo:HP_0002617, obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002093 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002637 obo:IAO_0000115 "Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue." ; oboInOwl:hasDbXref "MSH:D002545", "SNOMEDCT_US:287731003", "SNOMEDCT_US:389100007", "UMLS:C0007786", "UMLS:C0917798" ; oboInOwl:hasExactSynonym "Brain ischemia", "Cerebrovascular ischemia", "Disruption of blood oxygen supply to brain" ; oboInOwl:id "HP:0002637" ; a owl:Class ; rdfs:label "Cerebral ischemia" ; rdfs:subClassOf obo:HP_0033401 . obo:HP_0002638 obo:IAO_0000115 "Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein)." ; oboInOwl:hasDbXref "SNOMEDCT_US:2477008", "UMLS:C1510431" ; oboInOwl:id "HP:0002638" ; a owl:Class ; rdfs:label "Superficial thrombophlebitis" ; rdfs:subClassOf obo:HP_0004418 . obo:HP_0002639 obo:IAO_0000115 "Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava (IVC) with the right atrium, 1 and occurs in 1/100,000 of the general population worldwide. The most common presentation is with ascites, but can range from fulminant hepatic failure (FHF) to asymptomatic forms. Obstruction of hepatic venous outflow is mainly caused by primary intravascular thrombosis, which can occur suddenly or be repeated over time, accompanied by some revascularization, accounting for the variable parenchymal hepatic damage and histologic presentation. Budd-Chiari syndrome is thus a disease, but since it occurs as a manifestation of several other diseases, this term is kept for the present for convenience." ; oboInOwl:hasDbXref "MSH:D006502", "SNOMEDCT_US:82385007", "UMLS:C0856761" ; oboInOwl:id "HP:0002639" ; a owl:Class ; rdfs:label "Budd-Chiari syndrome" ; rdfs:subClassOf obo:HP_0030846 . obo:HP_0002640 obo:IAO_0000115 "A type of hypertension associated with pheochromocytoma." ; oboInOwl:hasDbXref "UMLS:C4025693" ; oboInOwl:id "HP:0002640" ; a owl:Class ; rdfs:label "Hypertension associated with pheochromocytoma" ; rdfs:subClassOf obo:HP_0000822 . obo:HP_0002641 oboInOwl:hasDbXref "UMLS:C1849749" ; oboInOwl:hasExactSynonym "Peripheral blood clot" ; oboInOwl:id "HP:0002641" ; a owl:Class ; rdfs:label "Peripheral thrombosis" ; rdfs:subClassOf obo:HP_0001977 . obo:HP_0002642 oboInOwl:hasDbXref "UMLS:C1857693" ; oboInOwl:hasExactSynonym "Arteriovenous fistulas of coeliac and mesenteric vessels" ; oboInOwl:id "HP:0002642" ; a owl:Class ; rdfs:label "Arteriovenous fistulas of celiac and mesenteric vessels" ; rdfs:subClassOf obo:HP_0002624, obo:HP_0004947 . obo:HP_0002643 obo:IAO_0000115 "Respiratory difficulty as newborn." ; oboInOwl:hasDbXref "UMLS:C0852283" ; oboInOwl:hasExactSynonym "Infantile respiratory distress", "Neonatal respiratory distress", "Newborn respiratory distress", "Respiratory distress, neonatal" ; oboInOwl:id "HP:0002643" ; a owl:Class ; rdfs:label "Neonatal respiratory distress" ; rdfs:subClassOf obo:HP_0002093 . obo:HP_0002644 obo:IAO_0000115 "An abnormality of the bony pelvic girdle, which is a ring of bones connecting the vertebral column to the femurs." ; oboInOwl:hasDbXref "UMLS:C4020847" ; oboInOwl:hasExactSynonym "Abnormal shape of pelvic girdle bone", "Abnormality of pelvic girdle bone morphology" ; oboInOwl:hasRelatedSynonym "Abnormality of the pelvic girdle" ; oboInOwl:id "HP:0002644" ; a owl:Class ; rdfs:label "Abnormal pelvic girdle bone morphology" ; rdfs:subClassOf obo:HP_0011844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002645 obo:IAO_0000115 "The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium." ; oboInOwl:hasDbXref "SNOMEDCT_US:113194005", "UMLS:C0222716" ; oboInOwl:hasExactSynonym "Extra bones within cranial sutures", "Intra sutural bones", "Intrasutural bones", "Islands of bone within cranial sutures" ; oboInOwl:id "HP:0002645" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Irregular, solated bones in the lambdoidal suture or at the fontanelles." ; rdfs:label "Wormian bones" ; rdfs:subClassOf obo:HP_0011329 . obo:HP_0002647 obo:IAO_0000115 "Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta." ; oboInOwl:hasAlternativeId "HP:0002622" ; oboInOwl:hasDbXref "SNOMEDCT_US:308546005", "UMLS:C0340643" ; oboInOwl:hasExactSynonym "Tear in inner wall of large artery that carries blood away from heart" ; oboInOwl:id "HP:0002647" ; a owl:Class ; rdfs:label "Aortic dissection" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0002648 obo:IAO_0100001 "HP:0002683" ; oboInOwl:id "HP:0002648" ; a owl:Class ; rdfs:label "obsolete Abnormality of calvarial morphology" ; owl:deprecated true . obo:HP_0002650 obo:IAO_0000115 "The presence of an abnormal lateral curvature of the spine." ; oboInOwl:hasAlternativeId "HP:0002770", "HP:0003303", "HP:0003317", "HP:0003415" ; oboInOwl:hasDbXref "Fyler:4160", "MSH:D013121", "SNOMEDCT_US:111266001", "SNOMEDCT_US:64217002", "UMLS:C0037932", "UMLS:C0700208" ; oboInOwl:id "HP:0002650" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Scoliosis" ; rdfs:subClassOf obo:HP_0010674 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002651 oboInOwl:hasDbXref "SNOMEDCT_US:254062008", "UMLS:C0432211" ; oboInOwl:id "HP:0002651" ; a owl:Class ; rdfs:label "Spondyloepimetaphyseal dysplasia" ; rdfs:subClassOf obo:HP_0002652 . obo:HP_0002652 obo:IAO_0000115 "A general term describing features characterized by abnormal development of bones and connective tissues." ; oboInOwl:hasAlternativeId "HP:0005685" ; oboInOwl:hasBroadSynonym "Abnormal skeletal development" ; oboInOwl:hasDbXref "MSH:D010009", "SNOMEDCT_US:105985007", "SNOMEDCT_US:240190009", "UMLS:C0029422", "UMLS:C4280567" ; oboInOwl:id "HP:0002652" ; a owl:Class ; rdfs:comment "The word skeletal dysplasia is most often used to describe a group of over 380 inherited conditions that involve abnormal development of bones and connective tissues. However, the word can also be used to describe the presence of congenital defects of bones or connective tissues that are found in one or more of the diseases, especially on prenatal ultrasound, i.e., a situation in which it is often not yet possible to make an exact etiological diagnosis. This is the sense of the phrase we use in the HPO. It is, however, preferable to annotate the observed abnormalities." ; rdfs:label "Skeletal dysplasia" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002653 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone." ; oboInOwl:hasDbXref "SNOMEDCT_US:12584003", "UMLS:C0151825" ; oboInOwl:hasExactSynonym "Bone pain" ; oboInOwl:id "HP:0002653" ; a owl:Class ; rdfs:label "Bone pain" ; rdfs:subClassOf obo:HP_0011843, obo:HP_0012531 . obo:HP_0002654 oboInOwl:hasDbXref "MSH:D010009", "SNOMEDCT_US:59708000", "UMLS:C0026760" ; oboInOwl:id "HP:0002654" ; a owl:Class ; rdfs:label "Multiple epiphyseal dysplasia" ; rdfs:subClassOf obo:HP_0002652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:HP_0002656 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002655 obo:IAO_0000115 "A disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses)." ; oboInOwl:hasAlternativeId "HP:0002776", "HP:0005893" ; oboInOwl:hasDbXref "MSH:D010009", "UMLS:C0038015" ; oboInOwl:hasExactSynonym "Spondyloepiphyseal dysplasia tarda" ; oboInOwl:id "HP:0002655" ; a owl:Class ; rdfs:label "Spondyloepiphyseal dysplasia" ; rdfs:subClassOf obo:HP_0002652 . obo:HP_0002656 oboInOwl:hasBroadSynonym "Abnormal development of end part of bone" ; oboInOwl:hasDbXref "SNOMEDCT_US:254080004", "UMLS:C0392476", "UMLS:C4280566" ; oboInOwl:hasExactSynonym "Abnormal development of the ends of long bones in arms and legs" ; oboInOwl:id "HP:0002656" ; a owl:Class ; rdfs:label "Epiphyseal dysplasia" ; rdfs:subClassOf obo:HP_0002652, obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002657 oboInOwl:hasDbXref "MSH:C537501", "SNOMEDCT_US:702350003", "UMLS:C0700635" ; oboInOwl:id "HP:0002657" ; a owl:Class ; rdfs:label "Spondylometaphyseal dysplasia" ; rdfs:subClassOf obo:HP_0002652 . obo:HP_0002659 obo:IAO_0000115 "An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture." ; oboInOwl:hasAlternativeId "HP:0002662", "HP:0002798", "HP:0005710", "HP:0005783", "HP:0005931" ; oboInOwl:hasDbXref "UMLS:C1390474" ; oboInOwl:hasExactSynonym "Abnormal susceptibility to fractures", "Bone fragility", "Frequent broken bones", "Increased bone fragility", "Increased susceptibility to fractures", "Increased tendency to fractures" ; oboInOwl:id "HP:0002659" ; a owl:Class ; rdfs:comment "This is a bundled term that will be made obsolete." ; rdfs:label "Increased susceptibility to fractures" ; rdfs:subClassOf obo:HP_0011843 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002055 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002661 obo:IAO_0000115 "An increased tendency to fractures following trauma, with fractures occurring without pain." ; oboInOwl:hasDbXref "UMLS:C1837602" ; oboInOwl:hasExactSynonym "Painless fractures due to injury" ; oboInOwl:id "HP:0002661" ; a owl:Class ; rdfs:label "Painless fractures due to injury" ; rdfs:subClassOf obo:HP_0002659, obo:HP_0010832 . obo:HP_0002663 oboInOwl:hasAlternativeId "HP:0005862" ; oboInOwl:hasDbXref "UMLS:C1865200", "UMLS:C4280565" ; oboInOwl:hasExactSynonym "Delayed epiphyseal maturation", "Delayed opacification of the epiphyses", "Epiphyseal ossification delay" ; oboInOwl:hasRelatedSynonym "Delayed maturation of end part of long bone" ; oboInOwl:id "HP:0002663" ; a owl:Class ; rdfs:label "Delayed epiphyseal ossification" ; rdfs:subClassOf obo:HP_0005930, obo:HP_0010656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001437 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002664 obo:IAO_0000115 "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." ; oboInOwl:hasAlternativeId "HP:0003008", "HP:0006741" ; oboInOwl:hasBroadSynonym "Abnormal tissue mass" ; oboInOwl:hasDbXref "MSH:D009369", "NCIT:C3262", "SNOMEDCT_US:108369006", "SNOMEDCT_US:363346000", "UMLS:C0006826", "UMLS:C0027651" ; oboInOwl:hasExactSynonym "Neoplasia", "Oncological abnormality", "Tumor", "Tumour" ; oboInOwl:hasRelatedSynonym "Cancer", "Oncology" ; oboInOwl:id "HP:0002664" ; a owl:Class ; rdfs:comment "The World Health Organization (WHO) classifies neoplasms into four main groups: (i) benign neoplasm, (ii) in situ neoplasm, (iii) malignant neoplasm, and (iv) neoplasm of uncertain or unknown behavior. A malignant neoplasm is also known as cancer." ; rdfs:label "Neoplasm" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0002665 obo:IAO_0000115 "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." ; oboInOwl:hasDbXref "MSH:D008223", "NCIT:C7065", "SNOMEDCT_US:115244002", "SNOMEDCT_US:118600007", "SNOMEDCT_US:188676008", "SNOMEDCT_US:21964009", "UMLS:C0024299" ; oboInOwl:hasExactSynonym "Cancer of lymphatic system" ; oboInOwl:id "HP:0002665" ; a owl:Class ; rdfs:label "Lymphoma" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0002666 obo:IAO_0000115 "Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines." ; oboInOwl:hasDbXref "MSH:D010673", "NCIT:C3326", "SNOMEDCT_US:302835009", "SNOMEDCT_US:399343007", "SNOMEDCT_US:85583005", "UMLS:C0031511" ; oboInOwl:hasExactSynonym "Chromaffin tumors", "Chromaffin tumours" ; oboInOwl:id "HP:0002666" ; a owl:Class ; rdfs:label "Pheochromocytoma" ; rdfs:subClassOf obo:HP_0100634 . obo:HP_0002667 obo:IAO_0000115 "The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children." ; oboInOwl:hasAlternativeId "HP:0000115" ; oboInOwl:hasDbXref "MSH:D009396", "NCIT:C40407", "SNOMEDCT_US:25081006", "SNOMEDCT_US:302849000", "UMLS:C0027708" ; oboInOwl:hasExactSynonym "Wilms tumor", "Wilms tumour" ; oboInOwl:id "HP:0002667" ; a owl:Class ; rdfs:comment "Nephroblastoma is characterized by an abnormal proliferation of the metanephric blastema cells, which are believed to be primitive embryologic cells of the kidney. Clinically, nephroblastoma usually presents as an abdominal mass, and in some cases with abdominal pain, hypertension, hematuria, and fever." ; rdfs:label "Nephroblastoma" ; rdfs:subClassOf obo:HP_0011794 . obo:HP_0002668 obo:IAO_0000115 "A carotid body tumor (also called paraganglionoma or chemodectoma) is a tumor found in the upper neck at the branching of the carotid artery. They arise from the chemoreceptor organ (paraganglion) located in the adventitia of the carotid artery bifurcation." ; oboInOwl:hasAlternativeId "HP:0002670", "HP:0003004" ; oboInOwl:hasDbXref "MSH:D010235", "NCIT:C3308", "SNOMEDCT_US:127027008", "SNOMEDCT_US:253029009", "SNOMEDCT_US:302833002", "SNOMEDCT_US:72787006", "SNOMEDCT_US:803009", "UMLS:C0030421" ; oboInOwl:hasExactSynonym "Carotid body tumors", "Carotid body tumours", "Paragangliomas" ; oboInOwl:id "HP:0002668" ; a owl:Class ; rdfs:label "Paraganglioma" ; rdfs:subClassOf obo:HP_0100634 . obo:HP_0002669 obo:IAO_0000115 "A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor." ; oboInOwl:hasDbXref "MSH:D012516", "NCIT:C9145", "SNOMEDCT_US:21708004", "SNOMEDCT_US:307576001", "UMLS:C0029463" ; oboInOwl:hasExactSynonym "Bone cell cancer", "Osteogenic sarcoma" ; oboInOwl:id "HP:0002669" ; a owl:Class ; rdfs:label "Osteosarcoma" ; rdfs:subClassOf obo:HP_0010622, obo:HP_0100242 . obo:HP_0002671 obo:IAO_0000115 "The presence of a basal cell carcinoma of the skin." ; oboInOwl:hasDbXref "MSH:D002280", "NCIT:C2921", "SNOMEDCT_US:1338007", "SNOMEDCT_US:254701007", "SNOMEDCT_US:275265005", "UMLS:C0007117", "UMLS:C1862314" ; oboInOwl:hasExactSynonym "Basal cell carcinomas", "Basal cell epithelioma", "Basal cell nevus", "Basalioma" ; oboInOwl:id "HP:0002671" ; a owl:Class ; rdfs:comment "A basal cell carcinoma is the most common type of skin cancer which rarely metastasizes, but is still considered malignant because it can cause significant destruction and disfigurement by invading surrounding tissues. In 80 percent of all cases, basal cell cancers are found on the head and neck or on other sun-exposed areas of the body. Apart from sporadic basal cell carcinoma, there are hereditary conditions such as the basal cell nevus syndrome where patients develop multiple basal cell carcinomas throughout life." ; rdfs:label "Basal cell carcinoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0002672 oboInOwl:hasDbXref "UMLS:C0151544" ; oboInOwl:hasExactSynonym "GI carcinoma" ; oboInOwl:id "HP:0002672" ; a owl:Class ; rdfs:label "Gastrointestinal carcinoma" ; rdfs:subClassOf obo:HP_0006749 . obo:HP_0002673 obo:IAO_0000115 "Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults)." ; oboInOwl:hasDbXref "MSH:D060906", "SNOMEDCT_US:299236004", "UMLS:C0239137", "UMLS:C3549698" ; oboInOwl:hasExactSynonym "Valgus hip" ; oboInOwl:hasRelatedSynonym "Coxa valga deformity" ; oboInOwl:id "HP:0002673" ; a owl:Class ; rdfs:label "Coxa valga" ; rdfs:subClassOf obo:HP_0003367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002327 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0006862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002676 obo:IAO_0000115 "Trilobar skull configuration when viewed from the front or behind." ; oboInOwl:hasAlternativeId "HP:0004477", "HP:0005459" ; oboInOwl:hasBroadSynonym "Cloverleaf cranium shape", "Cloverleaf skull shape", "Trilobar cranium shape", "Trilobar skull shape" ; oboInOwl:hasDbXref "UMLS:C1860050", "UMLS:C4280564" ; oboInOwl:hasExactSynonym "Kleeblattschaedel" ; oboInOwl:id "HP:0002676" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A deformity of the skull that resembles a cloverleaf and is characterized by very prominent temporal bones with constriction of the remainder of the cranium. Cloverleaf skull is commonly accompanied by hydrocephalus. See figure 3 in PMID:29089832." ; rdfs:label "Cloverleaf skull" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0002677 obo:IAO_0000115 "An abnormal narrowing of the foramen magnum." ; oboInOwl:hasAlternativeId "HP:0005468" ; oboInOwl:hasDbXref "SNOMEDCT_US:444879009", "UMLS:C1535953", "UMLS:C1861217", "UMLS:C4072838" ; oboInOwl:hasExactSynonym "Foramen magnum stenosis", "Little foramen magnum", "Narrow foramen magnum" ; oboInOwl:hasNarrowSynonym "Hypoplasia of foramen magnum", "Stenosis of foramen magnum" ; oboInOwl:id "HP:0002677" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The foramen magnum is the aperture through which the medulla oblongata enters and exits the skull. Stenosis of the foramen magnum can represent a risk for compression to the spinal cord." ; rdfs:label "Small foramen magnum" ; rdfs:subClassOf obo:HP_0002699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002678 oboInOwl:hasBroadSynonym "Abnormality of skull shape", "Unequal skull shape", "Uneven skull shape" ; oboInOwl:hasDbXref "SNOMEDCT_US:248372000", "UMLS:C0424690", "UMLS:C4280562", "UMLS:C4280563" ; oboInOwl:hasExactSynonym "Asymmetry of skull", "Skull asymmetry" ; oboInOwl:hasRelatedSynonym "Malformation of skull shape" ; oboInOwl:id "HP:0002678" ; a owl:Class ; rdfs:label "Skull asymmetry" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002679 obo:IAO_0000115 "Abnormality of the sella turcica, a saddle-shaped depression in the sphenoid bone at the base of the human skull." ; oboInOwl:hasDbXref "UMLS:C4021754", "UMLS:C4072839" ; oboInOwl:hasExactSynonym "Abnormality of the sella turcica", "Anomaly of the sella turcica" ; oboInOwl:hasNarrowSynonym "Abnormality of the hypophysial fossa", "Abnormality of the pituitary fossa", "Anomaly of the hypophysial fossa", "Anomaly of the pituitary fossa" ; oboInOwl:id "HP:0002679" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal sella turcica morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002680 obo:IAO_0000115 "A deformity of the sella turcica whereby the sella extends further anterior than normal such that the anterior clinoid process appears to overhang it, giving the appearance of the letter J on imaging of the skull." ; oboInOwl:hasDbXref "UMLS:C1854718", "UMLS:C4072841", "UMLS:C4072842" ; oboInOwl:hasExactSynonym "Hour glass shaped hypophysial fossa", "Hour glass shaped pituitary fossa", "Hour glass shaped sella turcica", "J-shaped sella", "Omega shaped sella turcica" ; oboInOwl:hasNarrowSynonym "J-shaped hypophysial fossa", "J-shaped pituitary fossa", "Omega shaped hypophysial fossa", "Omega shaped pituitary fossa" ; oboInOwl:id "HP:0002680" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "J-shaped sella turcica" ; rdfs:subClassOf obo:HP_0002681 . obo:HP_0002681 oboInOwl:hasDbXref "UMLS:C1846437" ; oboInOwl:hasExactSynonym "Abnormal shape of hypophysial fossa", "Abnormal shape of pituitary fossa", "Abnormal shape of sella turcica", "Deformity of hypophysial fossa", "Deformity of pituitary fossa", "Malformation of hypophysial fossa", "Malformation of pituitary fossa", "Malformation of sella turcica" ; oboInOwl:id "HP:0002681" ; a owl:Class ; rdfs:label "Deformed sella turcica" ; rdfs:subClassOf obo:HP_0002679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002682 obo:IAO_0000115 "Increased width of the skull." ; oboInOwl:hasDbXref "SNOMEDCT_US:248374004", "UMLS:C0424693" ; oboInOwl:hasExactSynonym "Broad cranium", "Broad skull", "Increased width of cranium", "Increased width of skull", "Wide cranium", "Wide skull" ; oboInOwl:id "HP:0002682" ; a owl:Class ; rdfs:label "Broad skull" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002683 obo:IAO_0000115 "Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain." ; oboInOwl:hasAlternativeId "HP:0002648" ; oboInOwl:hasBroadSynonym "Abnormality of cranium" ; oboInOwl:hasDbXref "UMLS:C4025691", "UMLS:C4280561" ; oboInOwl:hasExactSynonym "Abnormality of calvarium", "Abnormality of cranial vault", "Abnormality of the calvaria", "Abnormality of the shape of calvarium", "Abnormality of the skull cap", "Abnormality of the skullcap" ; oboInOwl:id "HP:0002683" ; a owl:Class ; rdfs:comment "The calvaria, or skull cap, is the upper part of the skull (cranium) and comprises the frontal, occipital and right and left parietal bones. Occasionally, calvaria is misspelled as 'calvarium' in the medical literature." ; rdfs:label "Abnormal calvaria morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002684 obo:IAO_0000115 "The presence of an abnormally thick calvaria." ; oboInOwl:hasBroadSynonym "Increased thickness of cranium" ; oboInOwl:hasDbXref "UMLS:C1858452", "UMLS:C4280560" ; oboInOwl:hasExactSynonym "Calvarial thickening", "Calvarium thickened", "Increased calvarial thickness", "Increased thickness of calvaria", "Increased thickness of calvarium", "Increased thickness of cranial vault", "Increased thickness of skull cap", "Thick calvaria", "Thick calvarium", "Thickened calvarium", "Thickened cranial vault", "Thickened cranium", "Thickened skull cap", "Thickening of the calvaria" ; oboInOwl:id "HP:0002684" ; a owl:Class ; rdfs:label "Thickened calvaria" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002686 obo:IAO_0000115 "Medical history of maternal diseases, exposures, or other relevant findings during the pregnancy of which the index person was the product." ; oboInOwl:hasDbXref "UMLS:C4025690" ; oboInOwl:hasExactSynonym "Prenatal maternal abnormality" ; oboInOwl:hasRelatedSynonym "Maternal health problem" ; oboInOwl:id "HP:0002686" ; a owl:Class ; rdfs:label "Pregnancy history" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0002687 obo:IAO_0000115 "An abnormality of the frontal sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The frontal sinus is located within the frontal bone." ; oboInOwl:hasDbXref "UMLS:C4025689" ; oboInOwl:hasExactSynonym "Abnormality of sinus frontalis", "Abnormality of the forehead sinus" ; oboInOwl:id "HP:0002687" ; a owl:Class ; rdfs:label "Abnormality of frontal sinus" ; rdfs:subClassOf obo:HP_0000245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001760 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002688 obo:IAO_0000115 "Aplasia of frontal sinus." ; oboInOwl:hasAlternativeId "HP:0005452", "HP:0005475" ; oboInOwl:hasDbXref "UMLS:C1855669", "UMLS:C4280559" ; oboInOwl:hasExactSynonym "Absence of frontal sinuses", "Absent frontal sinus", "Missing frontal sinus" ; oboInOwl:hasNarrowSynonym "Aplasia of frontal sinus", "Aplasia sinus frontalis" ; oboInOwl:id "HP:0002688" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent frontal sinuses" ; rdfs:subClassOf obo:HP_0009119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001760 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002689 obo:IAO_0000115 "Aplasia of the paranasal sinuses." ; oboInOwl:hasBroadSynonym "Missing sinuses" ; oboInOwl:hasDbXref "UMLS:C1857131", "UMLS:C3804986", "UMLS:C4072844" ; oboInOwl:hasExactSynonym "Absence of paranasal sinuses", "Missing paranasal sinuses" ; oboInOwl:hasNarrowSynonym "Aplasia of paranasal sinuses" ; oboInOwl:id "HP:0002689" ; a owl:Class ; rdfs:label "Absent paranasal sinuses" ; rdfs:subClassOf obo:HP_0005453 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001825 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002690 obo:IAO_0000115 "An abnormal enlargement of the sella turcica." ; oboInOwl:hasAlternativeId "HP:0005444" ; oboInOwl:hasDbXref "UMLS:C1843677", "UMLS:C4072845", "UMLS:C4072846" ; oboInOwl:hasExactSynonym "Big sella turcica", "Enlarged sella turcica", "Hyperplasia of sella turcica", "Prominent sella turcica" ; oboInOwl:hasNarrowSynonym "Hyperplasia of hypophysial fossa", "Hyperplasia of pituitary fossa", "Large hypophysial fossa", "Large pituitary fossa" ; oboInOwl:id "HP:0002690" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Large sella turcica" ; rdfs:subClassOf obo:HP_0002679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002691 obo:IAO_0000115 "A developmental malformation of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward such that there is an abnormal flattening of the skull base." ; oboInOwl:hasBroadSynonym "Flattening of the skull base" ; oboInOwl:hasDbXref "MSH:D010985", "SNOMEDCT_US:86587003", "UMLS:C0032209" ; oboInOwl:hasExactSynonym "Increased basal angle of skull base", "Obtuse basal angle of skull base" ; oboInOwl:id "HP:0002691" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Platybasia is malformation of the base of the skull due to softening of skull bones or a developmental anomaly, with bulging upwards of the floor of the posterior cranial fossa, upward displacement of the upper cervical vertebrae, and bony impingement on the brainstem. It results in abnormal obtuseness of the basal angle that can be demonstrated radiographically. If platybasia is associated with basilar invagination, compression of the brainstem and upper cervical cord can result. Basal Angle formed by: line joining the nasion with the centre of the pituitary fossa line joining the anterior border of the foramen magnum with the centre of the pituitary fossa normal: 125 degrees-143 degrees platybasia: > 143 degrees basilar kyphosis: < 125 degrees." ; rdfs:label "Platybasia" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0002692 oboInOwl:hasBroadSynonym "Hypoplasia of facial skeleton", "Small facial bones", "Small facial skeleton", "Underdevelopment of facial bones", "Underdevelopment of facial skeleton" ; oboInOwl:hasDbXref "UMLS:C1846438", "UMLS:C4229090", "UMLS:C4280268", "UMLS:C4280557", "UMLS:C4280558" ; oboInOwl:hasExactSynonym "Decreased size of facial bones", "Decreased size of facial skeleton" ; oboInOwl:hasRelatedSynonym "Flattening of facial bones", "Flattening of facial skeleton", "Hypotrophic facial bones", "Hypotrophic facial skeleton" ; oboInOwl:id "HP:0002692" ; a owl:Class ; rdfs:label "Hypoplastic facial bones" ; rdfs:subClassOf obo:HP_0034261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002693 obo:IAO_0000115 "An abnormality of the base of the skull, which forms the floor of the cranial cavity and separates the brain from other facial structures. The skull base is made up of five bones: the ethmoid, sphenoid, occipital, paired frontal, and paired parietal bones, and is subdivided into 3 regions: the anterior, middle, and posterior cranial fossae. The petro-occipital fissure subdivides the middle cranial fossa into 1 central component and 2 lateral components." ; oboInOwl:hasDbXref "UMLS:C4025688" ; oboInOwl:hasExactSynonym "Abnormality of cranial base", "Abnormality of the skull base" ; oboInOwl:id "HP:0002693" ; a owl:Class ; rdfs:label "Abnormal skull base morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002694 obo:IAO_0000115 "Increased bone density of the skull base without significant changes in bony contour." ; oboInOwl:hasAlternativeId "HP:0005757" ; oboInOwl:hasDbXref "UMLS:C1851714", "UMLS:C4072847", "UMLS:C4072848" ; oboInOwl:hasExactSynonym "Dense bone of skull base", "Hyperossification of skull base", "Hyperostosis of skull base", "Marked sclerosis of skull base", "Sclerosis of cranial base", "Sclerosis of the skull base", "Sclerotic skull base" ; oboInOwl:hasNarrowSynonym "HyperCalcification of skull base", "HyperMineralization of skull base" ; oboInOwl:id "HP:0002694" ; a owl:Class ; rdfs:label "Sclerosis of skull base" ; rdfs:subClassOf obo:HP_0002693, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002695 obo:IAO_0100001 "HP:0002697" ; oboInOwl:id "HP:0002695" ; a owl:Class ; rdfs:label "obsolete Symmetrical, oval parietal bone defects" ; owl:deprecated true . obo:HP_0002696 obo:IAO_0000115 "Any abnormality of the parietal bone of the skull." ; oboInOwl:hasDbXref "UMLS:C4021834" ; oboInOwl:hasExactSynonym "Abnormality of the parietal bone", "Abnormality of the parietal bone of skull" ; oboInOwl:id "HP:0002696" ; a owl:Class ; rdfs:label "Abnormal parietal bone morphology" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002697 obo:IAO_0000115 "The presence of symmetrical and circular openings (foramina) in the parietal bone ranging in size from a few millimeters to several centimeters wide." ; oboInOwl:hasAlternativeId "HP:0002695" ; oboInOwl:hasDbXref "SNOMEDCT_US:11240000", "SNOMEDCT_US:29307005", "UMLS:C0222706", "UMLS:C4280556" ; oboInOwl:hasExactSynonym "Persistent foramina of the parietal bones", "Symmetrical, oval defects in the parietal bone", "Symmetrical, oval parietal bone defects" ; oboInOwl:hasRelatedSynonym "Holes in parietal bones", "Openings in parietal bones" ; oboInOwl:id "HP:0002697" ; a owl:Class ; rdfs:comment "Enlarged parietal foramina is an inherited condition of impaired skull development. It is characterized by enlarged openings (foramina) in the two bones (parietal bones) that form the top and sides of the skull. This condition is due to problems with bone formation (ossification) within the parietal bones. The openings are symmetrical and circular in shape, with variable size ranging from a few millimeters to several centimeters wide. Parietal foramina are a normal feature of fetal development, but they usually close by the fifth month of pregnancy." ; rdfs:label "Parietal foramina" ; rdfs:subClassOf obo:HP_0002696 . obo:HP_0002699 obo:IAO_0000115 "Any abnormality of the foramen magnum." ; oboInOwl:hasDbXref "UMLS:C4025687" ; oboInOwl:hasExactSynonym "Abnormality of the foramen magnum" ; oboInOwl:id "HP:0002699" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The foramen magnum is the aperture through which the medulla oblongata enters and exits the skull." ; rdfs:label "Abnormal foramen magnum morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002700 obo:IAO_0000115 "An abnormal increase in the size of the foramen magnum." ; oboInOwl:hasDbXref "UMLS:C1844508", "UMLS:C4073291", "UMLS:C4280554", "UMLS:C4280555" ; oboInOwl:hasExactSynonym "Big foramen magnum", "Dilation of foramen magnum", "Enlarged foramen magnum", "Wide foramen magnum" ; oboInOwl:hasNarrowSynonym "Increased circumference of foramen magnum", "Increased diameter of foramen magnum" ; oboInOwl:id "HP:0002700" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Large foramen magnum" ; rdfs:subClassOf obo:HP_0002699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002703 obo:IAO_0000115 "An abnormality of the process of ossification of the skull." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T11:53:00Z" ; oboInOwl:hasBroadSynonym "Abnormality of skull bone formation" ; oboInOwl:hasDbXref "UMLS:C4025686", "UMLS:C4280550", "UMLS:C4280551", "UMLS:C4280552", "UMLS:C4280553" ; oboInOwl:hasNarrowSynonym "Abnormality of ossification of calvarium", "Abnormality of ossification of cranium" ; oboInOwl:hasRelatedSynonym "Abnormality of bone calcification of calvarium", "Abnormality of bone calcification of cranium", "Abnormality of bone calcification of skull", "Abnormality of bone formation of calvarium", "Abnormality of bone formation of cranium", "Abnormality of bone mineralization of calvarium", "Abnormality of bone mineralization of cranium", "Abnormality of bone mineralization of skull" ; oboInOwl:id "HP:0002703" ; a owl:Class ; rdfs:comment "The bones of the skull derive directly from mesenchyme cells by intramembranous ossification." ; rdfs:label "Abnormality of skull ossification" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002705 obo:IAO_0000115 "The presence of a high and narrow palate." ; oboInOwl:hasDbXref "UMLS:C1837404" ; oboInOwl:hasExactSynonym "Gothic palate", "High narrow palate", "High vaulted palate", "High, narrow palate", "Narrow and high arched palate", "Narrow, high-arched palate", "Narrow, high-arched roof of mouth", "Narrow, highly arched palate", "Narrow, highly arched roof of mouth" ; oboInOwl:id "HP:0002705" ; a owl:Class ; rdfs:label "High, narrow palate" ; rdfs:subClassOf obo:HP_0000189, obo:HP_0000218 . obo:HP_0002707 obo:IAO_0000115 "The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the palate." ; oboInOwl:hasAlternativeId "HP:0000229" ; oboInOwl:hasDbXref "UMLS:C1857699", "UMLS:C4280267" ; oboInOwl:hasExactSynonym "Palatal angioectasia", "Palatal telangiectasia", "Palate telangiectases", "Palate teleangiectases", "Telangiectasia of the roof of the mouth" ; oboInOwl:hasRelatedSynonym "Palatal spider veins", "Spider veins of the roof of the mouth" ; oboInOwl:id "HP:0002707" ; a owl:Class ; rdfs:label "Palate telangiectasia" ; rdfs:subClassOf obo:HP_0000174, obo:HP_0000228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001716 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002708 obo:IAO_0000115 "Unusual prominence of the median palatal raphe, which is the ridge formed by the fusion of the two plates of the skull that form the hard palate." ; oboInOwl:hasDbXref "UMLS:C1845108" ; oboInOwl:hasExactSynonym "Prominent central palatal ridge", "Prominent central ridge on roof of the mouth", "Prominent medial palatal suture" ; oboInOwl:id "HP:0002708" ; a owl:Class ; rdfs:label "Prominent median palatal raphe" ; rdfs:subClassOf obo:HP_0000174 . obo:HP_0002710 obo:IAO_0000115 "A depression located at an oral commissure." ; oboInOwl:hasDbXref "UMLS:C0399605" ; oboInOwl:hasExactSynonym "Commissural labial pits", "Commissural pit", "Lip pits at corners of the mouth", "Pits at the corners of the lips" ; oboInOwl:id "HP:0002710" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Commissural lip pits have no relationship to other forms of lip pits which may be located on the vermilion of the upper or lower lip, usually paramedian. Rather, commissural pits are located at the corners of the oral aperture." ; rdfs:label "Commissural lip pit" ; rdfs:subClassOf obo:HP_0100267 . obo:HP_0002711 obo:IAO_0000115 "Increased depth of the median tongue furrow." ; oboInOwl:hasDbXref "UMLS:C1845109" ; oboInOwl:hasExactSynonym "Deep central lingual furrow", "Deep central lingual groove", "Deep central tongue furrow", "Deep central tongue groove", "Deep median lingual furrow", "Deep median lingual groove", "Deep median tongue furrow", "Deep median tongue groove", "Exaggerated median lingual furrow" ; oboInOwl:id "HP:0002711" ; a owl:Class ; rdfs:label "Exaggerated median tongue furrow" ; rdfs:subClassOf obo:HP_0000221 . obo:HP_0002714 obo:IAO_0000115 "A morphological abnormality of the mouth in which the angle of the mouth is downturned. The oral commissures are positioned inferior to the midline labial fissure." ; oboInOwl:hasAlternativeId "HP:0000192" ; oboInOwl:hasDbXref "UMLS:C1866195" ; oboInOwl:hasExactSynonym "Downturned corners of mouth", "Downturned corners of the mouth", "Downturned mouth", "Downturned oral commisures" ; oboInOwl:id "HP:0002714" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding should be assessed with the mouth closed, the lips in relaxed contact, and the face relaxed. The finding may be difficult to assess if the lower lip is enlarged. Previous terms for downturned corners of mouth included Carp mouth andFish mouth which are no longer recommended (pejorative terms)." ; rdfs:label "Downturned corners of mouth" ; rdfs:subClassOf obo:HP_0011338 . obo:HP_0002715 obo:IAO_0000115 "An abnormality of the immune system." ; oboInOwl:hasAlternativeId "HP:0003257", "HP:0003346", "HP:0010986" ; oboInOwl:hasDbXref "UMLS:C4021753" ; oboInOwl:hasExactSynonym "Abnormality of the immune system", "Immunological abnormality" ; oboInOwl:id "HP:0002715" ; a owl:Class ; rdfs:comment "The immune system is composed of organs and interdependent cell types that collectively protect the body from infections and from the growth of tumor cells. The organs of the immune system comprise the bone marrow, the spleen, the thymus,the lymph nodes, and the cell types comprise B cells, T cells, natural killer cells, granulocytes,dendritic cells, and macrophages." ; rdfs:label "Abnormality of the immune system" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002405 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002716 obo:IAO_0000115 "Enlargment (swelling) of a lymph node." ; oboInOwl:hasAlternativeId "HP:0002735" ; oboInOwl:hasDbXref "MSH:D000072281", "SNOMEDCT_US:30746006", "UMLS:C0497156" ; oboInOwl:hasExactSynonym "Lymph node hyperplasia", "Swollen lymph nodes" ; oboInOwl:id "HP:0002716" ; a owl:Class ; rdfs:label "Lymphadenopathy" ; rdfs:subClassOf obo:HP_0002733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002717 dcterms:creator ; oboInOwl:creation_date "2008-02-25T10:41:00Z" ; oboInOwl:hasDbXref "UMLS:C4025685" ; oboInOwl:id "HP:0002717" ; a owl:Class ; rdfs:comment "Cortisol is the main member of the glucocorticoid family in humans and together with aldosterone is one of the main secretions of the adrenal cortex." ; rdfs:label "Adrenal overactivity" ; rdfs:subClassOf obo:HP_0011733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001625 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002718 obo:IAO_0000115 "Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection." ; oboInOwl:hasAlternativeId "HP:0005355", "HP:0005361", "HP:0005367", "HP:0005391", "HP:0005393", "HP:0005410" ; oboInOwl:hasDbXref "SNOMEDCT_US:428875002", "UMLS:C1844383", "UMLS:C2748958", "UMLS:C4020846" ; oboInOwl:hasExactSynonym "Bacterial infections, recurrent", "Frequent bacterial infections", "Frequent pyogenic infections", "Increased susceptibility to bacterial infections", "Recurrent bacterial infections", "Recurrent major bacterial infections", "Recurrent pyogenic infections", "Susceptibility to pyogenic infection" ; oboInOwl:hasRelatedSynonym "Prone to bacterial infection" ; oboInOwl:id "HP:0002718" ; a owl:Class ; rdfs:label "Recurrent bacterial infections" ; rdfs:subClassOf obo:HP_0002719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001669 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0042742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002719 obo:IAO_0000115 "Increased susceptibility to infections." ; oboInOwl:hasAlternativeId "HP:0002957", "HP:0002964", "HP:0005405" ; oboInOwl:hasDbXref "UMLS:C0239998" ; oboInOwl:hasExactSynonym "Frequent infections", "Frequent, severe infections", "Increased frequency of infection", "Predisposition to infections", "Recurrent infections", "Susceptibility to infection", "infections, recurrent" ; oboInOwl:id "HP:0002719" ; a owl:Class ; rdfs:label "Recurrent infections" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0002720 obo:IAO_0000115 "Decreased levels of immunoglobulin A (IgA)." ; oboInOwl:hasAlternativeId "HP:0005358", "HP:0005399", "HP:0005431", "HP:0008350" ; oboInOwl:hasDbXref "MSH:D017098", "SNOMEDCT_US:29260007", "UMLS:C0162538" ; oboInOwl:hasExactSynonym "Decreased IgA", "Decreased immunoglobulin A", "Gamma-A globulin deficiency", "IgA deficiency", "Low levels of immunoglobulin A", "Reduced IgA levels" ; oboInOwl:id "HP:0002720" ; a owl:Class ; rdfs:label "Decreased circulating IgA level" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0410240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002721 obo:IAO_0000115 "Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance." ; oboInOwl:hasAlternativeId "HP:0005362", "HP:0005371" ; oboInOwl:hasDbXref "MSH:D007153", "SNOMEDCT_US:234532001", "UMLS:C0021051" ; oboInOwl:hasExactSynonym "Decreased immune function", "Immune deficiency" ; oboInOwl:id "HP:0002721" ; a owl:Class ; rdfs:label "Immunodeficiency" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002722 obo:IAO_0000115 "An increased susceptibility to abscess formation, as manifested by a medical history of recurrent abscesses." ; oboInOwl:hasDbXref "UMLS:C4025684" ; oboInOwl:id "HP:0002722" ; a owl:Class ; rdfs:label "Recurrent abscess formation" ; rdfs:subClassOf obo:HP_0002719 . obo:HP_0002723 obo:IAO_0000115 "An absence of the phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." ; oboInOwl:hasDbXref "UMLS:C1844385" ; oboInOwl:id "HP:0002723" ; a owl:Class ; rdfs:label "Absence of bactericidal oxidative respiratory burst in phagocytes" ; rdfs:subClassOf obo:HP_0010977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0045728 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002724 obo:IAO_0000115 "An increased susceptibility to Aspergillus infections, as manifested by a history of recurrent episodes of Aspergillus infections." ; oboInOwl:hasDbXref "UMLS:C4021752" ; oboInOwl:hasExactSynonym "Aspergillus infections, recurrent" ; oboInOwl:id "HP:0002724" ; a owl:Class ; rdfs:label "Recurrent Aspergillus infections" ; rdfs:subClassOf obo:HP_0002841 . obo:HP_0002725 obo:IAO_0000115 "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." ; oboInOwl:hasDbXref "MSH:D008180", "SNOMEDCT_US:55464009", "UMLS:C0024141" ; oboInOwl:hasExactSynonym "SLE" ; oboInOwl:id "HP:0002725" ; a owl:Class ; rdfs:comment "This is a bundled term that describes a disease rather than a phenotypic feature, but is left for convenience for annotations of lupus conceived of as a feature of another disease." ; rdfs:label "Systemic lupus erythematosus" ; rdfs:subClassOf obo:HP_0002960 . obo:HP_0002726 obo:IAO_0000115 "Increased susceptibility to Staphylococcus aureus infections, as manifested by recurrent episodes of Staphylococcus aureus infection." ; oboInOwl:hasDbXref "UMLS:C2673462" ; oboInOwl:hasExactSynonym "Staphylococcus aureus infections, recurrent" ; oboInOwl:id "HP:0002726" ; a owl:Class ; rdfs:label "Recurrent Staphylococcus aureus infections" ; rdfs:subClassOf obo:HP_0007499 . obo:HP_0002728 obo:IAO_0000115 "Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails." ; oboInOwl:hasAlternativeId "HP:0005392" ; oboInOwl:hasDbXref "MSH:D002178", "SNOMEDCT_US:234568006", "UMLS:C0006845" ; oboInOwl:hasExactSynonym "Chronic candidiasis of mucosa, skin and nails", "Mucocutaneous candidiasis" ; oboInOwl:id "HP:0002728" ; a owl:Class ; rdfs:comment "The most commonly involved Candida species is Candida albicans. Chronic mucocutaneous candidiasis (CMC) is usually confined to the cutaneous surface without systemic dissemination. CMC does not represent a specific disease, but rather a phenotypic feature of several immunologic, endocrinologic, and autoimmune disorders." ; rdfs:label "Chronic mucocutaneous candidiasis" ; rdfs:subClassOf obo:HP_0011370 . obo:HP_0002729 obo:IAO_0000115 "Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers." ; oboInOwl:hasDbXref "UMLS:C4014733" ; oboInOwl:id "HP:0002729" ; a owl:Class ; rdfs:comment "Lymphadenopathy can be defined as enlargement of lymph nodes. It is just a sign accompanying a great variety of entities with multiple etiologies: acute vs. chronic, benign vs. malignant. One of the most commonly seen histological pictures is lymphadenopathy owing to hyperplasia of follicular (germinal centers) but this one is by far not the only one (See Gaddey HL et al. Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis. Am Fam Physician. 2016 1;94:896-903 and Weiss LM. et al. Benign lymphadenopathies. Mod Pathol. 2013;26 Suppl 1:S88-96)." ; rdfs:label "Follicular hyperplasia" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0002730 obo:IAO_0000115 "A chronic form of lymphadenopathy that is not related to infection." ; oboInOwl:hasDbXref "UMLS:C1858970" ; oboInOwl:id "HP:0002730" ; a owl:Class ; rdfs:label "Chronic noninfectious lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0002731 obo:IAO_0000115 "A reduction in the rate of apoptosis in lymphocytes." ; oboInOwl:hasDbXref "UMLS:C1858969" ; oboInOwl:hasExactSynonym "Defective lymphocyte apoptosis" ; oboInOwl:id "HP:0002731" ; a owl:Class ; rdfs:comment "Apoptosis, a form of programmed cell death, is an important mechanism that prevents uncontrolled proliferation of activated lymphocytes and regulates lymphocyte homeostasis." ; rdfs:label "Decreased lymphocyte apoptosis" ; rdfs:subClassOf obo:HP_0030886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070227 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002732 obo:IAO_0000115 "Underdevelopment of the lymph nodes." ; oboInOwl:hasDbXref "UMLS:C1865377", "UMLS:C4025683" ; oboInOwl:hasRelatedSynonym "Small lymph nodes" ; oboInOwl:id "HP:0002732" ; a owl:Class ; rdfs:label "Lymph node hypoplasia" ; rdfs:subClassOf obo:HP_0002733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002733 obo:IAO_0000115 "A structural lymph node abnormality." ; oboInOwl:hasAlternativeId "HP:0008149" ; oboInOwl:hasDbXref "UMLS:C0149727" ; oboInOwl:hasExactSynonym "Abnormal lymph node histology", "Abnormality of the lymph nodes" ; oboInOwl:id "HP:0002733" ; a owl:Class ; rdfs:label "Abnormal lymph node morphology" ; rdfs:subClassOf obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002737 oboInOwl:hasDbXref "UMLS:C1839507" ; oboInOwl:hasExactSynonym "Increased thickness of bone of skull base", "Increased thickness of skull base", "Thick skull base" ; oboInOwl:id "HP:0002737" ; a owl:Class ; rdfs:label "Thick skull base" ; rdfs:subClassOf obo:HP_0002693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002738 obo:IAO_0000115 "Underdevelopment of frontal sinus." ; oboInOwl:hasDbXref "UMLS:C1859682", "UMLS:C4280548", "UMLS:C4280549" ; oboInOwl:hasExactSynonym "Decreased volume of frontal sinuses", "Small frontal sinuses", "Underdeveloped frontal sinuses" ; oboInOwl:hasNarrowSynonym "Decreased pneumatization of frontal sinus" ; oboInOwl:hasRelatedSynonym "Hypotrophic frontal sinus" ; oboInOwl:id "HP:0002738" ; a owl:Class ; rdfs:label "Hypoplastic frontal sinuses" ; rdfs:subClassOf obo:HP_0009119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001760 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002740 obo:IAO_0000115 "Increased susceptibility to infections with Escherichia coli, as manifested by recurrent episodes of infection with this agent." ; oboInOwl:hasDbXref "MSH:D004927", "SNOMEDCT_US:71057007", "UMLS:C0014836" ; oboInOwl:hasExactSynonym "E coli infections", "E coli infections, recurrent" ; oboInOwl:id "HP:0002740" ; a owl:Class ; rdfs:label "Recurrent E. coli infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0002741 obo:IAO_0000115 "Increased susceptibility to Serratia marcescens infections, as manifested by recurrent episodes of Serratia marcescens infection." ; oboInOwl:hasDbXref "UMLS:C4025682" ; oboInOwl:id "HP:0002741" ; a owl:Class ; rdfs:label "Recurrent Serratia marcescens infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0002742 obo:IAO_0000115 "Increased susceptibility to Klebsiella infections, as manifested by recurrent episodes of Klebsiella infection." ; oboInOwl:hasDbXref "UMLS:C4021751" ; oboInOwl:hasExactSynonym "Klebsiella infections, recurrent" ; oboInOwl:id "HP:0002742" ; a owl:Class ; rdfs:label "Recurrent Klebsiella infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0002743 obo:IAO_0000115 "Increased susceptibility to enteroviral infections, as manifested by recurrent episodes of enteroviral infection." ; oboInOwl:hasDbXref "UMLS:C4025681" ; oboInOwl:id "HP:0002743" ; a owl:Class ; rdfs:label "Recurrent enteroviral infections" ; rdfs:subClassOf obo:HP_0004429 . obo:HP_0002744 obo:IAO_0000115 "Cleft lip and cleft palate affecting both sides of the face." ; oboInOwl:hasDbXref "SNOMEDCT_US:1085331000119107", "UMLS:C1398522" ; oboInOwl:hasExactSynonym "Bilateral cleft lip and cleft palate", "Right and left cleft lip and palate" ; oboInOwl:id "HP:0002744" ; a owl:Class ; rdfs:label "Bilateral cleft lip and palate" ; rdfs:subClassOf obo:HP_0100336, obo:HP_0100337 . obo:HP_0002745 obo:IAO_0000115 "A thickened white patch on the oral mucosa that cannot be rubbed off." ; oboInOwl:hasDbXref "MSH:D007971", "MSH:D007972", "SNOMEDCT_US:414603003", "SNOMEDCT_US:9187004", "UMLS:C0023532", "UMLS:C1704317" ; oboInOwl:hasExactSynonym "Oral idiopathic keratosis", "Oral idiopathic leukoplakia", "Oral idiopathic white patch", "Oral leucoplakia", "Oral leukokeratosis", "Oral leukoplasia", "Oral white patch", "Oral white plaque", "leukokeratosis" ; oboInOwl:id "HP:0002745" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The definition of oral leukoplakia states that the lesion be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. Leukoplakia is a precancerous lesion, i.e. a morphologically altered tissue in which cancer is more likely to occur than in its apparently normal counterpart." ; rdfs:label "Oral leukoplakia" ; rdfs:subClassOf obo:HP_0025125 . obo:HP_0002747 oboInOwl:hasAlternativeId "HP:0004882", "HP:0004888" ; oboInOwl:hasDbXref "UMLS:C3806467" ; oboInOwl:hasExactSynonym "Decreased lung function due to weak breathing muscles", "Decreased respiratory function due to muscle weakness", "Respiratory distress due to muscle weakness", "Respiratory failure due to muscle weakness", "Respiratory muscle weakness" ; oboInOwl:id "HP:0002747" ; a owl:Class ; rdfs:label "Respiratory insufficiency due to muscle weakness" ; rdfs:subClassOf obo:HP_0002093, obo:HP_0004347 . obo:HP_0002748 obo:IAO_0000115 "Rickets is divided into two major categories including calcipenic and phosphopenic. Hypophosphatemia is described as a common manifestation of both categories. Hypophosphatemic rickets is the most common type of rickets that is characterized by low levels of serum phosphate, resistance to ultraviolet radiation or vitamin D intake. There are several issues involved in hypophosphatemic rickets such as calcium, vitamin D, phosphorus deficiencies. Moreover, other disorder can be associated with its occurrence such as absorption defects due to pancreatic, intestinal, gastric, and renal disorders and hepatobiliary disease. Symptoms are usually seen in childhood and can be varied in severity. Severe forms may be linked to bowing of the legs, poor bone growth, and short stature as well as joint and bone pain. Hypophosphatemic rickets are associated with renal excretion of phosphate, hypophosphatemia, and mineral defects in bones. The familial type of the disease is the most common type of rickets." ; oboInOwl:hasDbXref "MSH:D012279", "SNOMEDCT_US:41345002", "UMLS:C0035579" ; oboInOwl:hasExactSynonym "Weak and soft bones" ; oboInOwl:id "HP:0002748" ; a owl:Class ; rdfs:label "Rickets" ; rdfs:subClassOf obo:HP_0004349 . obo:HP_0002749 obo:IAO_0000115 "Osteomalacia is a general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets." ; oboInOwl:hasDbXref "SNOMEDCT_US:4598005", "UMLS:C0029442" ; oboInOwl:hasExactSynonym "Softening of the bones" ; oboInOwl:id "HP:0002749" ; a owl:Class ; rdfs:label "Osteomalacia" ; rdfs:subClassOf obo:HP_0004349 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002750 obo:IAO_0000115 "A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." ; oboInOwl:hasAlternativeId "HP:0000928", "HP:0002806" ; oboInOwl:hasDbXref "SNOMEDCT_US:123983008", "UMLS:C0541764" ; oboInOwl:hasExactSynonym "Delayed bone age", "Delayed bone age before puberty", "Delayed bone maturation", "Delayed skeletal development", "Retarded bone age", "Skeletal maturation retardation" ; oboInOwl:hasRelatedSynonym "Retarded ossification" ; oboInOwl:id "HP:0002750" ; a owl:Class ; rdfs:label "Delayed skeletal maturation" ; rdfs:subClassOf obo:HP_0000927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070977 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004288 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002751 obo:IAO_0000115 "An abnormal curvature of the spine in both a coronal (lateral) and sagittal (back-to-front) plane." ; oboInOwl:hasAlternativeId "HP:0003412", "HP:0003424", "HP:0004593", "HP:0005728" ; oboInOwl:hasDbXref "SNOMEDCT_US:405773007", "UMLS:C0575158" ; oboInOwl:id "HP:0002751" ; a owl:Class ; rdfs:label "Kyphoscoliosis" ; rdfs:subClassOf obo:HP_0002650, obo:HP_0002808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0002650 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0002808 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002752 oboInOwl:hasDbXref "UMLS:C1833324" ; oboInOwl:id "HP:0002752" ; a owl:Class ; rdfs:label "Sparse bone trabeculae" ; rdfs:subClassOf obo:HP_0100671 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002753 obo:IAO_0000115 "Abnormal thinning of the cortical region of bones." ; oboInOwl:hasAlternativeId "HP:0003104" ; oboInOwl:hasDbXref "UMLS:C1833325" ; oboInOwl:hasExactSynonym "Thin cortices" ; oboInOwl:id "HP:0002753" ; a owl:Class ; rdfs:label "Thin bony cortex" ; rdfs:subClassOf obo:HP_0003103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001439 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002754 obo:IAO_0000115 "Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism." ; oboInOwl:hasAlternativeId "HP:0002755", "HP:0005901" ; oboInOwl:hasDbXref "MSH:D010019", "SNOMEDCT_US:111253001", "SNOMEDCT_US:60168000", "UMLS:C0029443", "UMLS:C2242472" ; oboInOwl:hasExactSynonym "Bone infection" ; oboInOwl:id "HP:0002754" ; a owl:Class ; rdfs:comment "Osteomyelitis can be acute or chronic and can be caused by a variety of microbial agents." ; rdfs:label "Osteomyelitis" ; rdfs:subClassOf obo:HP_0011843, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002755 obo:IAO_0100001 "HP:0002754" ; oboInOwl:id "HP:0002755" ; a owl:Class ; rdfs:label "obsolete Osteomyelitis due to immunodeficiency" ; owl:deprecated true . obo:HP_0002756 obo:IAO_0000115 "A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone." ; oboInOwl:hasAlternativeId "HP:0005633" ; oboInOwl:hasDbXref "MSH:D005598", "SNOMEDCT_US:22640007", "SNOMEDCT_US:268029009", "UMLS:C0016663" ; oboInOwl:hasExactSynonym "Spontaneous fracture" ; oboInOwl:hasRelatedSynonym "Pathologic fractures", "Spontaneous fractures" ; oboInOwl:id "HP:0002756" ; a owl:Class ; rdfs:label "Pathologic fracture" ; rdfs:subClassOf obo:HP_0002659 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002659 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002757 obo:IAO_0000115 "The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture)." ; oboInOwl:hasAlternativeId "HP:0002660", "HP:0002767", "HP:0002809" ; oboInOwl:hasDbXref "MSH:D000069076", "SNOMEDCT_US:134291007", "SNOMEDCT_US:5468008", "UMLS:C0016655", "UMLS:C1833752", "UMLS:C3805574", "UMLS:C3806283" ; oboInOwl:hasExactSynonym "Frequent fractures", "Increased fracture rate", "Increased fractures", "Multiple fractures", "Multiple spontaneous fractures", "Recurrent fractures", "Varying degree of multiple fractures" ; oboInOwl:id "HP:0002757" ; a owl:Class ; rdfs:comment "This term will be made obsolete. The annotations need to be checked." ; rdfs:label "Recurrent fractures" ; rdfs:subClassOf obo:HP_0002659 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002659 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002758 obo:IAO_0000115 "Degeneration (wear and tear) of articular cartilage, i.e., of the joint surface. Joint degeneration may be accompanied by osteophytes (bone overgrowth), narrowing of the joint space, regions of sclerosis at the joint surface, or joint deformity." ; oboInOwl:hasAlternativeId "HP:0001379", "HP:0002824", "HP:0005762" ; oboInOwl:hasDbXref "MSH:D010003", "SNOMEDCT_US:225655006", "SNOMEDCT_US:396275006", "UMLS:C0029408" ; oboInOwl:hasExactSynonym "Degenerative joint disease" ; oboInOwl:id "HP:0002758" ; a owl:Class ; rdfs:label "Osteoarthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0002761 obo:IAO_0000115 "Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body." ; oboInOwl:hasDbXref "UMLS:C1836308" ; oboInOwl:hasExactSynonym "Generalised joint laxity", "Hypermobility of all joints" ; oboInOwl:hasRelatedSynonym "Joint laxity, generalised", "Joint laxity, generalized" ; oboInOwl:id "HP:0002761" ; a owl:Class ; rdfs:label "Generalized joint laxity" ; rdfs:subClassOf obo:HP_0001388 . obo:HP_0002762 obo:IAO_0000115 "Presence of more than one exostosis. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." ; oboInOwl:hasDbXref "MSH:D005097", "SNOMEDCT_US:254044004", "UMLS:C0015306" ; oboInOwl:id "HP:0002762" ; a owl:Class ; rdfs:label "Multiple exostoses" ; rdfs:subClassOf obo:HP_0100777 . obo:HP_0002763 obo:IAO_0000115 "Any morphological abnormality of cartilage." ; oboInOwl:hasAlternativeId "HP:0410007" ; oboInOwl:hasDbXref "UMLS:C4025680" ; oboInOwl:hasExactSynonym "Abnormal shape of cartilage", "Abnormality of cartilage morphology" ; oboInOwl:id "HP:0002763" ; a owl:Class ; rdfs:label "Abnormal cartilage morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002764 obo:IAO_0000115 "Punctate (speckled, dot-like) deposition of calcium of calcium salts in the articular cartilage (cartilage located in joints)." ; oboInOwl:hasDbXref "UMLS:C4025679" ; oboInOwl:id "HP:0002764" ; a owl:Class ; rdfs:comment "See the figure in PMID:29246349" ; rdfs:label "Stippled chondral calcification" ; rdfs:subClassOf obo:HP_0002832, obo:HP_0100593 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0002766 oboInOwl:hasDbXref "UMLS:C3277114" ; oboInOwl:hasExactSynonym "Relatively short spine" ; oboInOwl:id "HP:0002766" ; a owl:Class ; rdfs:label "Relatively short spine" ; rdfs:subClassOf obo:HP_0008518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002773 obo:IAO_0100001 "HP:0008479" ; oboInOwl:id "HP:0002773" ; a owl:Class ; rdfs:label "obsolete Small vertebral bodies" ; owl:deprecated true . obo:HP_0002777 oboInOwl:hasDbXref "MSH:D014135", "SNOMEDCT_US:11296007", "UMLS:C0040583" ; oboInOwl:hasExactSynonym "Narrowing of windpipe" ; oboInOwl:id "HP:0002777" ; a owl:Class ; rdfs:label "Tracheal stenosis" ; rdfs:subClassOf obo:HP_0002778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002778 obo:IAO_0000115 "A structural anomaly of the trachea." ; oboInOwl:hasDbXref "MSH:D014133", "SNOMEDCT_US:47125007", "UMLS:C0040580", "UMLS:C4025678" ; oboInOwl:hasExactSynonym "Abnormal trachea morphology", "Abnormality of the trachea" ; oboInOwl:hasRelatedSynonym "Tracheal disease" ; oboInOwl:id "HP:0002778" ; a owl:Class ; rdfs:label "Abnormal tracheal morphology" ; rdfs:subClassOf obo:HP_0005607 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002779 oboInOwl:hasDbXref "MSH:D055090", "SNOMEDCT_US:95434006", "UMLS:C0948187" ; oboInOwl:hasExactSynonym "Floppy windpipe" ; oboInOwl:id "HP:0002779" ; a owl:Class ; rdfs:label "Tracheomalacia" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0002780 obo:IAO_0000115 "Weakness or softness of the cartilage in the walls of the bronchial tubes." ; oboInOwl:hasDbXref "MSH:D055091", "SNOMEDCT_US:54203008", "UMLS:C0264353" ; oboInOwl:id "HP:0002780" ; a owl:Class ; rdfs:label "Bronchomalacia" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0002781 obo:IAO_0000115 "Increased resistance to the passage of air in the upper airway." ; oboInOwl:hasDbXref "UMLS:C0740852" ; oboInOwl:hasExactSynonym "Upper airway obstruction" ; oboInOwl:id "HP:0002781" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Upper airway obstruction" ; rdfs:subClassOf obo:HP_0006536 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001557 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002783 obo:IAO_0000115 "An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections." ; oboInOwl:hasAlternativeId "HP:0004884", "HP:0005955" ; oboInOwl:hasDbXref "SNOMEDCT_US:448739000", "SNOMEDCT_US:50417007", "UMLS:C0149725", "UMLS:C0585953", "UMLS:C3163798" ; oboInOwl:hasExactSynonym "Chronic lung infections", "Lower respiratory tract infections", "Recurrent chest infections" ; oboInOwl:id "HP:0002783" ; a owl:Class ; rdfs:label "Recurrent lower respiratory tract infections" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0002786 obo:IAO_0000115 "Weakness of the cartilage in the trachea and the bronchi, resulting in a floppy (non-rigid) airway. Affected persons may have difficulties to maintain patency of the airways." ; oboInOwl:hasDbXref "MSH:D055089", "SNOMEDCT_US:233788001", "UMLS:C0340231" ; oboInOwl:id "HP:0002786" ; a owl:Class ; rdfs:label "Tracheobronchomalacia" ; rdfs:subClassOf obo:HP_0002779, obo:HP_0002780 . obo:HP_0002787 obo:IAO_0000115 "Calcification (abnormal deposits of calcium) in the tracheal tissues." ; oboInOwl:hasDbXref "SNOMEDCT_US:81089005", "UMLS:C0264324" ; oboInOwl:hasExactSynonym "Calcification of the trachea", "Tracheal calcifications", "Tracheal ectopic calcification" ; oboInOwl:id "HP:0002787" ; a owl:Class ; rdfs:label "Tracheal calcification" ; rdfs:subClassOf obo:HP_0002778, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002788 obo:IAO_0000115 "An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis)." ; oboInOwl:hasAlternativeId "HP:0001740", "HP:0002784" ; oboInOwl:hasDbXref "SNOMEDCT_US:195708003", "UMLS:C0581381" ; oboInOwl:hasExactSynonym "Frequent upper respiratory infections", "Frequent upper respiratory tract infections", "Recurrent URI", "Recurrent colds", "Recurrent upper respiratory and lower respiratory infections", "Recurrent upper respiratory infection", "Recurrent upper respiratory infections", "Upper respiratory tract infections", "Upper respiratory tract infections, recurrent" ; oboInOwl:id "HP:0002788" ; a owl:Class ; rdfs:label "Recurrent upper respiratory tract infections" ; rdfs:subClassOf obo:HP_0001739, obo:HP_0002205 . obo:HP_0002789 obo:IAO_0000115 "Very rapid breathing." ; oboInOwl:hasAlternativeId "HP:0002874", "HP:0004346" ; oboInOwl:hasDbXref "MSH:D059246", "SNOMEDCT_US:271823003", "UMLS:C0231835" ; oboInOwl:hasExactSynonym "Increased respiratory rate or depth of breathing", "Polypnea" ; oboInOwl:id "HP:0002789" ; a owl:Class ; rdfs:comment "In adults, a beathing rate of between 12-20 breaths per minute is normal and tachypnea is present with a ventilatory rate greater than 20 breaths per minute." ; rdfs:label "Tachypnea" ; rdfs:subClassOf obo:HP_0002793 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002790 oboInOwl:hasDbXref "UMLS:C3806216" ; oboInOwl:hasExactSynonym "Impaired breathing in newborn" ; oboInOwl:id "HP:0002790" ; a owl:Class ; rdfs:label "Neonatal breathing dysregulation" ; rdfs:subClassOf obo:HP_0005957 . obo:HP_0002791 obo:IAO_0000115 "A reduction in the amount of air transported into the pulmonary alveoli by breathing, leading to hypercapnia (increase in the partial pressure of carbon dioxide)." ; oboInOwl:hasAlternativeId "HP:0004892" ; oboInOwl:hasDbXref "MSH:D007040", "MSH:D012131", "SNOMEDCT_US:15993004", "SNOMEDCT_US:31515003", "SNOMEDCT_US:80954004", "UMLS:C0235063", "UMLS:C3203358" ; oboInOwl:hasExactSynonym "Alveolar hypoventilation", "Slow breathing", "Under breathing" ; oboInOwl:hasRelatedSynonym "Respiratory depression" ; oboInOwl:id "HP:0002791" ; a owl:Class ; rdfs:comment "Not to be confused with Hypopnea, where the partial pressure of carbon dioxide can remain normal." ; rdfs:label "Hypoventilation" ; rdfs:subClassOf obo:HP_0002793 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000381 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002792 obo:IAO_0000115 "An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung." ; oboInOwl:hasDbXref "SNOMEDCT_US:274715008", "SNOMEDCT_US:607007", "UMLS:C0476408", "UMLS:C0520831" ; oboInOwl:hasExactSynonym "Decreased vital capacity" ; oboInOwl:id "HP:0002792" ; a owl:Class ; rdfs:label "Reduced vital capacity" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0002793 obo:IAO_0000115 "An anomaly of the rhythm or depth of breathing." ; oboInOwl:hasDbXref "UMLS:C1837388" ; oboInOwl:hasExactSynonym "Abnormal pattern of respiration", "Abnormal respiratory patterns", "Unusual breathing patterns" ; oboInOwl:id "HP:0002793" ; a owl:Class ; rdfs:label "Abnormal pattern of respiration" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0002795 oboInOwl:hasAlternativeId "HP:0005952" ; oboInOwl:hasDbXref "Fyler:4200", "UMLS:C4025677" ; oboInOwl:hasExactSynonym "Abnormal respiration", "Functional respiratory abnormality" ; oboInOwl:hasRelatedSynonym "Impaired pulmonary function", "Respiratory problem" ; oboInOwl:id "HP:0002795" ; a owl:Class ; rdfs:label "Abnormal respiratory system physiology" ; rdfs:subClassOf obo:HP_0002086 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002797 obo:IAO_0000115 "Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium." ; oboInOwl:hasAlternativeId "HP:0010737" ; oboInOwl:hasDbXref "MSH:D010014", "SNOMEDCT_US:203522001", "SNOMEDCT_US:30425001", "UMLS:C0221204" ; oboInOwl:hasExactSynonym "Breakdown of bone", "Increased bone resorption", "Osteolytic defects of bones" ; oboInOwl:id "HP:0002797" ; a owl:Class ; rdfs:comment "Osteolysis may be a feature of neoplastic, infectious, metabolis, vascular, and joint disorders and is also a component of many hereditary diseases. Osteolysis may be highly localized or more diffuse. This term is meant to group the more specific osteolysis terms." ; rdfs:label "Osteolysis" ; rdfs:subClassOf obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0045453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002803 obo:IAO_0000115 "One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth." ; oboInOwl:hasDbXref "UMLS:C0332878" ; oboInOwl:hasExactSynonym "Congenital joint contractures", "congenital contractures" ; oboInOwl:id "HP:0002803" ; a owl:Class ; rdfs:label "Congenital contracture" ; rdfs:subClassOf obo:HP_0001371 . obo:HP_0002804 obo:IAO_0000115 "Multiple congenital contractures in different body areas." ; oboInOwl:hasAlternativeId "HP:0001389", "HP:0001390", "HP:0002759", "HP:0005188", "HP:0005663", "HP:0005809", "HP:0005859" ; oboInOwl:hasDbXref "MSH:D001176", "SNOMEDCT_US:111246005", "SNOMEDCT_US:77016009", "UMLS:C0003886" ; oboInOwl:hasExactSynonym "Arthrogryposis", "Arthrogryposis multiplex", "Arthrogryposis, congenital", "Multiple congenital contractures" ; oboInOwl:id "HP:0002804" ; a owl:Class ; rdfs:comment "Arthrogryposis multiplex congenita (AMC) consists of several conditions of different etiology and mixed clinical features, including multiple congenital contractures in multiple body areas. Here, we use the term to refer solely to the multiple congenital contractures. It is related to fetal akinesia owing to fetal neurogenic, muscle, or connective tissue disorders or occasionally to maternal conditions. AMC can be associated with polyhydramnios, pulmonary hypoplasia, micrognathia, ocular hypertelorism, and short umbilical cord. AMC is a feature of a heterogeneous group of disorders, some of which have the phrase 'arthrogryposis multiplex congenita' as a part of their name (for instance, Arthrogryposis multiplex congenita, distal type 1 or AMCD1). This term refers to the finding of multiple joint contractures found throughout the body at birth rather than to the disease entities of which this is a clinical feature." ; rdfs:label "Arthrogryposis multiplex congenita" ; rdfs:subClassOf obo:HP_0002803 . obo:HP_0002805 oboInOwl:hasDbXref "UMLS:C1860825" ; oboInOwl:hasExactSynonym "Accelerated bone age after puberty" ; oboInOwl:id "HP:0002805" ; a owl:Class ; rdfs:label "Accelerated bone age after puberty" ; rdfs:subClassOf obo:HP_0005616 . obo:HP_0002808 obo:IAO_0000115 "Exaggerated anterior convexity of the thoracic vertebral column." ; oboInOwl:hasAlternativeId "HP:0002769", "HP:0003314" ; oboInOwl:hasDbXref "MSH:D007738", "SNOMEDCT_US:414564002", "UMLS:C0022821", "UMLS:C1845112" ; oboInOwl:hasExactSynonym "Gibbus deformity", "Hunched back", "Hyperkyphosis", "Round back" ; oboInOwl:id "HP:0002808" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Kyphosis" ; rdfs:subClassOf obo:HP_0010674 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001468 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002810 oboInOwl:hasAlternativeId "HP:0005079" ; oboInOwl:hasDbXref "UMLS:C3277123" ; oboInOwl:hasExactSynonym "Dumbbell shaped metaphyses", "Dumbbell shaped metaphysis", "Dumbbell shaped wide portion of long bone" ; oboInOwl:id "HP:0002810" ; a owl:Class ; rdfs:label "Dumbbell-shaped metaphyses" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001876 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002812 obo:IAO_0000115 "Coxa vara includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees." ; oboInOwl:hasDbXref "MSH:D060905", "SNOMEDCT_US:74820003", "UMLS:C0239138" ; oboInOwl:id "HP:0002812" ; a owl:Class ; rdfs:comment "The Latin word 'coxa' refers to the hip, and varus is a term for the inward angulation of the distal segment of a bone or joint. The normal range of the angle between the ball and the shaft of the femur is 120 to 135 degrees. Coxa vara can be congenital, developmental, or acquired." ; rdfs:label "Coxa vara" ; rdfs:subClassOf obo:HP_0003367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002328 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0006862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002813 obo:IAO_0000115 "Any abnormality of bones of the arms or legs." ; oboInOwl:hasDbXref "UMLS:C4082761" ; oboInOwl:hasExactSynonym "Abnormal shape of limb bone", "Arm and/or leg bone differences", "Limb abnormality" ; oboInOwl:id "HP:0002813" ; a owl:Class ; rdfs:label "Abnormality of limb bone morphology" ; rdfs:subClassOf obo:HP_0011844, obo:HP_0040068 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002428 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002814 obo:IAO_0000115 "An abnormality of the leg." ; oboInOwl:hasDbXref "SNOMEDCT_US:449715001", "UMLS:C1096086" ; oboInOwl:hasExactSynonym "Abnormality of the leg", "Abnormality of the lower limb", "Lower limb deformities" ; oboInOwl:id "HP:0002814" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the lower limb" ; rdfs:subClassOf obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002815 obo:IAO_0000115 "An abnormality of the knee joint or surrounding structures." ; oboInOwl:hasDbXref "UMLS:C4025676" ; oboInOwl:hasExactSynonym "Abnormality of the knee" ; oboInOwl:id "HP:0002815" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the knee" ; rdfs:subClassOf obo:HP_0100491 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002816 obo:IAO_0000115 "An abnormally increased extension of the knee joint, so that the knee can bend backwards." ; oboInOwl:hasDbXref "MEDDRA:10018194", "UMLS:C0546964" ; oboInOwl:hasExactSynonym "Back knee", "Genu recurvata", "Knee hyperextension" ; oboInOwl:id "HP:0002816" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Individuals with genu recurvatum may experience knee pain, display an extension gait pattern, and have poor proprioceptive control of terminal knee extension." ; rdfs:label "Genu recurvatum" ; rdfs:subClassOf obo:HP_0010500 . obo:HP_0002817 obo:IAO_0000115 "An abnormality of the arm." ; oboInOwl:hasAlternativeId "HP:0003838" ; oboInOwl:hasDbXref "UMLS:C4020900" ; oboInOwl:hasExactSynonym "Abnormality of the arm", "Abnormality of the upper limb" ; oboInOwl:id "HP:0002817" ; a owl:Class ; rdfs:label "Abnormality of the upper limb" ; rdfs:subClassOf obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002818 obo:IAO_0000115 "An abnormality of the radius." ; oboInOwl:hasAlternativeId "HP:0045009" ; oboInOwl:hasDbXref "UMLS:C4025675" ; oboInOwl:hasExactSynonym "Abnormality of the radius" ; oboInOwl:id "HP:0002818" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal morphology of the radius" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002821 oboInOwl:hasDbXref "MSH:D001177", "SNOMEDCT_US:359554008", "SNOMEDCT_US:67536000", "UMLS:C0003892" ; oboInOwl:hasExactSynonym "Charcot arthropathy", "Charcot joint" ; oboInOwl:id "HP:0002821" ; a owl:Class ; rdfs:label "Neuropathic arthropathy" ; rdfs:subClassOf obo:HP_0003040 . obo:HP_0002822 oboInOwl:hasDbXref "UMLS:C3277120" ; oboInOwl:hasExactSynonym "Hyperplastic femoral trochanters" ; oboInOwl:id "HP:0002822" ; a owl:Class ; rdfs:label "Hyperplasia of the femoral trochanters" ; rdfs:subClassOf obo:HP_0003366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000980 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002823 obo:IAO_0000115 "Any anomaly of the structure of the femur." ; oboInOwl:hasAlternativeId "HP:0001439" ; oboInOwl:hasDbXref "UMLS:C4021750" ; oboInOwl:hasExactSynonym "Abnormality of the femora", "Abnormality of the thighbone" ; oboInOwl:id "HP:0002823" ; a owl:Class ; rdfs:comment "The femur (plural: femora) is the thigh bone." ; rdfs:label "Abnormality of femur morphology" ; rdfs:subClassOf obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002825 obo:IAO_0000115 "The presence of a tail-like skin appendage located adjacent to the sacrum." ; oboInOwl:hasDbXref "UMLS:C3277117" ; oboInOwl:hasExactSynonym "Coccygeal tail", "Human tail" ; oboInOwl:id "HP:0002825" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Caudal appendage" ; rdfs:subClassOf obo:HP_0008519 . obo:HP_0002826 obo:IAO_0000115 "An anomalous radiographic appearance of the developing pelvis, in which the greater ischiadic noth (incisura ischiadica major) is shallow and the pelvis takes on the appearance said to resemble a halberd (a weapon especially of the 15th and 16th centuries consisting typically of a battle-ax and pike mounted on a handle)." ; oboInOwl:hasDbXref "UMLS:C3277119" ; oboInOwl:hasExactSynonym "Halberd-shaped pelvis bone" ; oboInOwl:id "HP:0002826" ; a owl:Class ; rdfs:label "Halberd-shaped pelvis" ; rdfs:subClassOf obo:HP_0040163 . obo:HP_0002827 obo:IAO_0000115 "Displacement of the femur from its normal location in the hip joint." ; oboInOwl:hasAlternativeId "HP:0001375" ; oboInOwl:hasDbXref "MSH:D006617", "SNOMEDCT_US:157265008", "UMLS:C0019554" ; oboInOwl:hasExactSynonym "Dislocated hips", "Dislocation of hip", "Hip dislocation" ; oboInOwl:id "HP:0002827" ; a owl:Class ; rdfs:label "Hip dislocation" ; rdfs:subClassOf obo:HP_0001384, obo:HP_0030311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002828 oboInOwl:hasDbXref "SNOMEDCT_US:19393004", "SNOMEDCT_US:202264009", "UMLS:C0158118" ; oboInOwl:id "HP:0002828" ; a owl:Class ; rdfs:label "Multiple joint contractures" ; rdfs:subClassOf obo:HP_0001371 . obo:HP_0002829 obo:IAO_0000115 "Joint pain." ; oboInOwl:hasDbXref "MSH:D018771", "SNOMEDCT_US:57676002", "UMLS:C0003862" ; oboInOwl:hasExactSynonym "Arthralgias", "Joint pain" ; oboInOwl:hasRelatedSynonym "Arthritic pain", "Joint pains" ; oboInOwl:id "HP:0002829" ; a owl:Class ; rdfs:comment "Arthralgia is distinct from Arthritis, which is not a symptom but a diagnosis with articular inflammation or signs of osteoarthritis." ; rdfs:label "Arthralgia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0002831 oboInOwl:hasDbXref "UMLS:C3277116" ; oboInOwl:hasExactSynonym "Long tailbone" ; oboInOwl:id "HP:0002831" ; a owl:Class ; rdfs:label "Long coccyx" ; rdfs:subClassOf obo:HP_0008519 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002832 obo:IAO_0000115 "An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs)." ; oboInOwl:hasAlternativeId "HP:0005738" ; oboInOwl:hasDbXref "UMLS:C1849993" ; oboInOwl:hasExactSynonym "Discrete calcific stippling" ; oboInOwl:id "HP:0002832" ; a owl:Class ; rdfs:label "Calcific stippling" ; rdfs:subClassOf obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030282 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002833 obo:IAO_0000115 "Disseminated multifocal hemangiomatous or lymphangiomatous lesions of the skeleton. The lesions are lytic, well-defined, round or oval lesions within the medullary cavity, and they have an intact cortex, and manifest variable peripheral sclerosis and may exhibit endosteal scalloping." ; oboInOwl:hasDbXref "UMLS:C4021749" ; oboInOwl:hasExactSynonym "Lytic cystic lesions in appendicular bones" ; oboInOwl:id "HP:0002833" ; a owl:Class ; rdfs:comment "The term Cystic angiomatosis is used to describe a disease entity that includes cystic angiomatosis of bone and of visceral organs." ; rdfs:label "Cystic angiomatosis of bone" ; rdfs:subClassOf obo:HP_0012062 . obo:HP_0002834 oboInOwl:hasDbXref "UMLS:C4025674" ; oboInOwl:hasExactSynonym "Flared metaphysis of thigh bone" ; oboInOwl:id "HP:0002834" ; a owl:Class ; rdfs:label "Flared femoral metaphysis" ; rdfs:subClassOf obo:HP_0006489, obo:HP_0030307 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002835 obo:IAO_0000115 "Inspiration of a foreign object into the airway." ; oboInOwl:hasDbXref "SNOMEDCT_US:413585005", "SNOMEDCT_US:68052005", "UMLS:C0700198", "UMLS:C2712334" ; oboInOwl:hasRelatedSynonym "Pulmonary aspiration" ; oboInOwl:id "HP:0002835" ; a owl:Class ; rdfs:label "Aspiration" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0002836 obo:IAO_0000115 "Eversion of the posterior bladder wall through the congenitally absent lower anterior abdominal wall and anterior bladder wall." ; oboInOwl:hasDbXref "MSH:D001746", "SNOMEDCT_US:61758007", "UMLS:C0005689" ; oboInOwl:hasExactSynonym "Ectopia vesicae" ; oboInOwl:id "HP:0002836" ; a owl:Class ; rdfs:comment "Exstrophy of the bladder can be associated with epispadias and bifid penis or in females with bifid clitoris, a bifid uterus, and a septated vagina, each of which should be coded separately." ; rdfs:label "Bladder exstrophy" ; rdfs:subClassOf obo:HP_0025487, obo:HP_0100548 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002837 obo:IAO_0000115 "An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis." ; oboInOwl:hasAlternativeId "HP:0002785" ; oboInOwl:hasDbXref "UMLS:C0741796" ; oboInOwl:hasExactSynonym "Bronchitis, recurrent" ; oboInOwl:id "HP:0002837" ; a owl:Class ; rdfs:label "Recurrent bronchitis" ; rdfs:subClassOf obo:HP_0002788, obo:HP_0012387, obo:HP_0025426 . obo:HP_0002839 obo:IAO_0000115 "Abnormal function of a sphincter of the urinary bladder." ; oboInOwl:hasAlternativeId "HP:0000018" ; oboInOwl:hasDbXref "UMLS:C1843663" ; oboInOwl:hasExactSynonym "Sphincter disturbance", "Sphincter disturbances" ; oboInOwl:id "HP:0002839" ; a owl:Class ; rdfs:label "Urinary bladder sphincter dysfunction" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0002840 obo:IAO_0000115 "Inflammation of a lymph node." ; oboInOwl:hasDbXref "MSH:D008199", "SNOMEDCT_US:19471005", "UMLS:C0024205" ; oboInOwl:hasExactSynonym "Inflammation of the lymph nodes" ; oboInOwl:id "HP:0002840" ; a owl:Class ; rdfs:label "Lymphadenitis" ; rdfs:subClassOf obo:HP_0002733, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002841 obo:IAO_0000115 "Increased susceptibility to fungal infections, as manifested by multiple episodes of fungal infection." ; oboInOwl:hasAlternativeId "HP:0005350", "HP:0005380", "HP:0005388" ; oboInOwl:hasDbXref "UMLS:C1844384" ; oboInOwl:hasExactSynonym "Recurrent fungal infections" ; oboInOwl:id "HP:0002841" ; a owl:Class ; rdfs:label "Recurrent fungal infections" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0020100 . obo:HP_0002842 obo:IAO_0000115 "Increased susceptibility to infections with Burkholderia cepacia, as manifested by recurrent episodes of infection with this agent." ; oboInOwl:hasDbXref "UMLS:C4025673" ; oboInOwl:id "HP:0002842" ; a owl:Class ; rdfs:label "Recurrent Burkholderia cepacia infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0002843 obo:IAO_0000115 "An abnormality of T cells." ; oboInOwl:hasAlternativeId "HP:0002734", "HP:0030332" ; oboInOwl:hasDbXref "UMLS:C1855752" ; oboInOwl:hasExactSynonym "Abnormal T cells", "Abnormality of T cells", "Cellular immune defect", "Defective cellular immunity" ; oboInOwl:id "HP:0002843" ; a owl:Class ; rdfs:comment "T-cells are lymphocytes whose principle function in the adaptive immune system is to mediate cell-mediated immunity." ; rdfs:label "Abnormal T cell morphology" ; rdfs:subClassOf obo:HP_0004332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002845 obo:IAO_0100001 "HP:0002851" ; oboInOwl:id "HP:0002845" ; a owl:Class ; rdfs:label "obsolete Increased proportion of peripheral CD3+ T cells" ; owl:deprecated true . obo:HP_0002846 obo:IAO_0000115 "A structural abnormality of B cells." ; oboInOwl:hasDbXref "UMLS:C4021748" ; oboInOwl:hasExactSynonym "Abnormal B cells", "Abnormality of B cells" ; oboInOwl:id "HP:0002846" ; a owl:Class ; rdfs:comment "B cells are bursal or bone marrow-derived lymphocytes whose principle function in the adaptive immune system is to make antibodies against antigens. A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors recognizing specific antigenic epitopes. Over 10 B cell-specific cell surface molecules have been identified by monoclonal antibodies, including CD19, which is considered a pan-B cell and possibly follicular dendritic cell marker, and CD20, which is considered to be a marker for mature B cells." ; rdfs:label "Abnormal B cell morphology" ; rdfs:subClassOf obo:HP_0004332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002847 obo:IAO_0000115 "Impaired production of memory cells, the B cells that persist for years or an entire lifetime and which confer rapid and enhanced response to secondary challenge." ; oboInOwl:hasDbXref "UMLS:C4025672" ; oboInOwl:id "HP:0002847" ; a owl:Class ; rdfs:label "Impaired memory B cell generation" ; rdfs:subClassOf obo:HP_0005372 . obo:HP_0002848 obo:IAO_0000115 "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against bacterial polysaccharides." ; oboInOwl:hasDbXref "UMLS:C4021747" ; oboInOwl:hasExactSynonym "Depressed antibody response to polysaccharide antigens", "Low specific anti-polysaccharide antibody titer", "Specific anti-polysaccharide antibody deficiency" ; oboInOwl:id "HP:0002848" ; a owl:Class ; rdfs:comment "Specific anti-polysaccharide antibody deficiency is associated with an increased risk of infection with Streptococcus pneumoniae, Haemophilus influenzae type b, and Staphylococcus aureus." ; rdfs:label "Decreased specific anti-polysaccharide antibody level" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0002849 obo:IAO_0000115 "Absence of germinal centers in lymph nodes. Germinal centers are the parts of lymph nodes in which B lymphocytes proliferate, differentiate, mutate through somatic hypermutation and class switch during antibody responses." ; oboInOwl:hasDbXref "UMLS:C1847383" ; oboInOwl:hasExactSynonym "Absence of lymph node germinal centre", "Lymph nodes lack germinal center", "Lymph nodes lack germinal centre", "Lymphoid germinal center defect", "Lymphoid germinal centre defect" ; oboInOwl:id "HP:0002849" ; a owl:Class ; rdfs:label "Absence of lymph node germinal center" ; rdfs:subClassOf obo:HP_0002733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009039 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002850 obo:IAO_0000115 "An abnormally decreased level of immunoglobulin M (IgM) in blood." ; oboInOwl:hasAlternativeId "HP:0003147", "HP:0005385" ; oboInOwl:hasDbXref "UMLS:C0239989" ; oboInOwl:hasExactSynonym "Decreased IgM", "Decreased IgM level", "IgM deficiency", "Reduced IgM levels" ; oboInOwl:id "HP:0002850" ; a owl:Class ; rdfs:label "Decreased circulating total IgM" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0410243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002851 obo:IAO_0000115 "An abnormally increased proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells." ; oboInOwl:hasAlternativeId "HP:0002845" ; oboInOwl:hasDbXref "UMLS:C1858973" ; oboInOwl:hasExactSynonym "Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors" ; oboInOwl:id "HP:0002851" ; a owl:Class ; rdfs:label "Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells" ; rdfs:subClassOf obo:HP_0031399 . obo:HP_0002853 obo:IAO_0000115 "An elevated proportion of T cells that express human leukocyte antigen (HLA)-DR. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation." ; oboInOwl:hasDbXref "UMLS:C1858974" ; oboInOwl:id "HP:0002853" ; a owl:Class ; rdfs:label "Increased proportion of HLA DR+ T cells" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0002857 obo:IAO_0000115 "The legs angle inward, such that the knees are close together and the ankles far apart." ; oboInOwl:hasAlternativeId "HP:0004999" ; oboInOwl:hasDbXref "MEDDRA:10023480", "MSH:D056304", "SNOMEDCT_US:299330008", "UMLS:C0576093" ; oboInOwl:hasExactSynonym "Genu valga", "Genu valgus", "Genua valga", "Knee joint valgus deformity", "Knock knees" ; oboInOwl:id "HP:0002857" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Genu valgum" ; rdfs:subClassOf obo:HP_0002979, obo:HP_0034669 . obo:HP_0002858 obo:IAO_0000115 "The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater." ; oboInOwl:hasAlternativeId "HP:0006754" ; oboInOwl:hasBroadSynonym "Noncancerous growth of membranes covering brain" ; oboInOwl:hasDbXref "MSH:D008579", "NCIT:C3230", "UMLS:C0025286" ; oboInOwl:id "HP:0002858" ; a owl:Class ; rdfs:label "Meningioma" ; rdfs:subClassOf obo:HP_0010651, obo:HP_0100835 . obo:HP_0002859 oboInOwl:hasDbXref "MSH:D012208", "NCIT:C3359", "SNOMEDCT_US:302847003", "SNOMEDCT_US:30924005", "UMLS:C0035412" ; oboInOwl:id "HP:0002859" ; a owl:Class ; rdfs:label "Rhabdomyosarcoma" ; rdfs:subClassOf obo:HP_0009728, obo:HP_0030448 . obo:HP_0002860 obo:IAO_0000115 "The presence of squamous cell carcinoma of the skin." ; oboInOwl:hasBroadSynonym "Squamous cell cancer" ; oboInOwl:hasDbXref "MSH:D002294", "MSH:D018307", "NCIT:C2929", "SNOMEDCT_US:28899001", "SNOMEDCT_US:402815007", "UMLS:C0007137", "UMLS:C0751688" ; oboInOwl:id "HP:0002860" ; a owl:Class ; rdfs:label "Squamous cell carcinoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0002861 obo:IAO_0000115 "The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea)." ; oboInOwl:hasAlternativeId "HP:0002887", "HP:0006777", "HP:0007474" ; oboInOwl:hasBroadSynonym "Cancer of skin pigment cells", "Skin cancer (melanoma)" ; oboInOwl:hasDbXref "MSH:D008545", "NCIT:C3224", "SNOMEDCT_US:2092003", "SNOMEDCT_US:372244006", "UMLS:C0025202" ; oboInOwl:hasExactSynonym "Malignant melanoma" ; oboInOwl:id "HP:0002861" ; a owl:Class ; rdfs:comment "A malignant skin tumor of originating from melanocytes, pigment cells normally present in the epidermis and sometimes in the dermis." ; rdfs:label "Melanoma" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0002862 obo:IAO_0000115 "The presence of a carcinoma of the urinary bladder." ; oboInOwl:hasDbXref "NCIT:C2916", "SNOMEDCT_US:255108000", "UMLS:C0699885" ; oboInOwl:id "HP:0002862" ; a owl:Class ; rdfs:label "Bladder carcinoma" ; rdfs:subClassOf obo:HP_0009725 . obo:HP_0002863 obo:IAO_0000115 "Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia." ; oboInOwl:hasAlternativeId "HP:0004832", "HP:0006730" ; oboInOwl:hasDbXref "MSH:D009190", "SNOMEDCT_US:109995007", "SNOMEDCT_US:128623006", "SNOMEDCT_US:188736006", "UMLS:C1851971", "UMLS:C3463824" ; oboInOwl:hasExactSynonym "Myelodysplastic syndrome" ; oboInOwl:hasRelatedSynonym "Hypoplastic myelodysplasia" ; oboInOwl:id "HP:0002863" ; a owl:Class ; rdfs:label "Myelodysplasia" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0002864 oboInOwl:hasDbXref "UMLS:C1333944" ; oboInOwl:hasExactSynonym "Paragangliomas, head and neck" ; oboInOwl:id "HP:0002864" ; a owl:Class ; rdfs:label "Paraganglioma of head and neck" ; rdfs:subClassOf obo:HP_0002668 . obo:HP_0002865 obo:IAO_0000115 "The presence of a medullary carcinoma of the thyroid gland." ; oboInOwl:hasBroadSynonym "Medullary thyroid cancer" ; oboInOwl:hasDbXref "MSH:C536914", "NCIT:C3879", "SNOMEDCT_US:128916007", "SNOMEDCT_US:255032005", "UMLS:C0238462" ; oboInOwl:id "HP:0002865" ; a owl:Class ; rdfs:label "Medullary thyroid carcinoma" ; rdfs:subClassOf obo:HP_0002890 . obo:HP_0002866 obo:IAO_0000115 "Underdevelopment of the ilium ala." ; oboInOwl:hasAlternativeId "HP:0003169", "HP:0003181", "HP:0008837" ; oboInOwl:hasDbXref "UMLS:C1865027" ; oboInOwl:hasExactSynonym "Hypoplastic iliac alae", "Hypoplastic iliac wings", "Small iliac wings" ; oboInOwl:id "HP:0002866" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic iliac wing" ; rdfs:subClassOf obo:HP_0000946, obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002867 obo:IAO_0000115 "An abnormality of the ilium, the largest and uppermost bone of the pelvis." ; oboInOwl:hasDbXref "UMLS:C4021746" ; oboInOwl:hasExactSynonym "Abnormality of the ilium", "Iliac abnormalities" ; oboInOwl:id "HP:0002867" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal ilium morphology" ; rdfs:subClassOf obo:HP_0003272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002868 obo:IAO_0000115 "Decreased width of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally)." ; oboInOwl:hasDbXref "UMLS:C1836688" ; oboInOwl:hasExactSynonym "Narrow iliac wings" ; oboInOwl:id "HP:0002868" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002869 obo:IAO_0000115 "Widening of the ilium ala, that is of the wing of the ilium, combined with external rotation, leading to a flared appearance of the iliac wing." ; oboInOwl:hasDbXref "UMLS:C1865841" ; oboInOwl:hasExactSynonym "Flared iliac wings" ; oboInOwl:id "HP:0002869" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "See Figure 4A of PMID:28744080." ; rdfs:label "Flared iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002870 obo:IAO_0000115 "A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow." ; oboInOwl:hasDbXref "MSH:D020181", "SNOMEDCT_US:78275009", "UMLS:C0520679" ; oboInOwl:hasRelatedSynonym "Obstructive sleep apnoea" ; oboInOwl:id "HP:0002870" ; a owl:Class ; rdfs:label "Obstructive sleep apnea" ; rdfs:subClassOf obo:HP_0010535 . obo:HP_0002871 obo:IAO_0000115 "Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow." ; oboInOwl:hasDbXref "MSH:D020182", "UMLS:C0520680" ; oboInOwl:hasExactSynonym "Central apnoea" ; oboInOwl:id "HP:0002871" ; a owl:Class ; rdfs:label "Central apnea" ; rdfs:subClassOf obo:HP_0002104 . obo:HP_0002872 obo:IAO_0000115 "Recurrent episodes of apnea that are precipitated by factors such as illness, fatigue, or stress." ; oboInOwl:hasDbXref "UMLS:C3806462" ; oboInOwl:hasExactSynonym "Episodic apnea induced by febrile illness or stress" ; oboInOwl:id "HP:0002872" ; a owl:Class ; rdfs:label "Apneic episodes precipitated by illness, fatigue, stress" ; rdfs:subClassOf obo:HP_0002104 . obo:HP_0002875 obo:IAO_0000115 "Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest." ; oboInOwl:hasDbXref "SNOMEDCT_US:60845006", "UMLS:C0231807" ; oboInOwl:hasExactSynonym "Exertional breathlessness", "Exertional dyspnoea", "Shortness of breathing upon physical activity" ; oboInOwl:id "HP:0002875" ; a owl:Class ; rdfs:label "Exertional dyspnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0002876 obo:IAO_0000115 "Episodes of very rapid breathing." ; oboInOwl:hasAlternativeId "HP:0002881" ; oboInOwl:hasDbXref "UMLS:C3806218" ; oboInOwl:hasExactSynonym "Hyperpnea, episodic" ; oboInOwl:id "HP:0002876" ; a owl:Class ; rdfs:label "Episodic tachypnea" ; rdfs:subClassOf obo:HP_0002789 . obo:HP_0002877 obo:IAO_0000115 "An abnormal reduction in alveolar ventilation occuring during sleep. This is characterized by a rise in arterial carbon dioxide." ; oboInOwl:hasDbXref "UMLS:C1843643" ; oboInOwl:hasExactSynonym "Hypoventilation during sleep", "Nocturnal hypopnea", "Nocturnal slow breathing", "Nocturnal under breathing" ; oboInOwl:id "HP:0002877" ; a owl:Class ; rdfs:label "Nocturnal hypoventilation" ; rdfs:subClassOf obo:HP_0002791 . obo:HP_0002878 obo:IAO_0000115 "A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits." ; oboInOwl:hasAlternativeId "HP:0004877" ; oboInOwl:hasDbXref "MSH:D012131", "SNOMEDCT_US:409622000", "UMLS:C1145670" ; oboInOwl:hasExactSynonym "Respiratory failure" ; oboInOwl:id "HP:0002878" ; a owl:Class ; rdfs:comment "Respiratory failure is classified as type 1 with hypoxemia (arterial partial pressure of oxygen less than 60 mmHg) without hypercapnea, and type 2 with hypoxemia in the present of hypercapnea (partial pressure of carbon dioxide over 50 mmHg)." ; rdfs:label "Respiratory failure" ; rdfs:subClassOf obo:HP_0002093 . obo:HP_0002879 obo:IAO_0000115 "Abnormally increased variability of the size of the vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C1857101" ; oboInOwl:id "HP:0002879" ; a owl:Class ; rdfs:label "Anisospondyly" ; rdfs:subClassOf obo:HP_0003312 . obo:HP_0002880 obo:IAO_0100001 "HP:0002098" ; oboInOwl:id "HP:0002880" ; a owl:Class ; rdfs:label "obsolete Respiratory difficulties" ; owl:deprecated true . obo:HP_0002882 obo:IAO_0000115 "Recurrent bouts of sudden, severe apnea that may be life-threatening." ; oboInOwl:hasDbXref "UMLS:C4025671" ; oboInOwl:id "HP:0002882" ; a owl:Class ; rdfs:label "Sudden episodic apnea" ; rdfs:subClassOf obo:HP_0002104 . obo:HP_0002883 obo:IAO_0000115 "Hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide." ; oboInOwl:hasDbXref "MSH:D006985", "SNOMEDCT_US:68978004", "UMLS:C0020578" ; oboInOwl:hasExactSynonym "Rapid breathing" ; oboInOwl:id "HP:0002883" ; a owl:Class ; rdfs:label "Hyperventilation" ; rdfs:subClassOf obo:HP_0002793 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000380 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002884 obo:IAO_0000115 "A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts." ; oboInOwl:hasDbXref "MSH:D018197", "NCIT:C3728", "SNOMEDCT_US:109843000", "SNOMEDCT_US:45024009", "UMLS:C0206624" ; oboInOwl:id "HP:0002884" ; a owl:Class ; rdfs:comment "Hepatoblastoma occurs nearly exclusively in infants and children." ; rdfs:label "Hepatoblastoma" ; rdfs:subClassOf obo:HP_0002896, obo:HP_0002898 . obo:HP_0002885 obo:IAO_0000115 "A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults." ; oboInOwl:hasDbXref "MSH:D008527", "NCIT:C3222", "SNOMEDCT_US:443333004", "SNOMEDCT_US:83217000", "UMLS:C0025149" ; oboInOwl:id "HP:0002885" ; a owl:Class ; rdfs:comment "Medulloblastoma is a highly malignant primary brain tumor that originates in the cerebellum or posterior fossa and belonging to the family of cranial primitive neuroectodermal tumors." ; rdfs:label "Medulloblastoma" ; rdfs:subClassOf obo:HP_0100836 . obo:HP_0002886 obo:IAO_0000115 "A tumor that develops in the retrostyloid compartment of the parapharyngeal space, arising from an island of paraganglion tissue derived from the neural crest that is located on the vagus nerve." ; oboInOwl:hasDbXref "SNOMEDCT_US:253030004", "UMLS:C0474819" ; oboInOwl:hasExactSynonym "Glomus vagale tumor", "Glomus vagale tumour", "Vagal nerve tumors", "Vagal nerve tumours" ; oboInOwl:hasRelatedSynonym "Glomus vagale paraganglioma" ; oboInOwl:id "HP:0002886" ; a owl:Class ; rdfs:label "Vagal paraganglioma" ; rdfs:subClassOf obo:HP_0002864 . obo:HP_0002888 obo:IAO_0000115 "The presence of an ependymoma of the central nervous system." ; oboInOwl:hasDbXref "MSH:D004806", "NCIT:C3017", "SNOMEDCT_US:443643007", "SNOMEDCT_US:57706008", "UMLS:C0014474" ; oboInOwl:id "HP:0002888" ; a owl:Class ; rdfs:comment "According to MPATH, ependymomas are neoplasms derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord and may be malignant or benign." ; rdfs:label "Ependymoma" ; rdfs:subClassOf obo:HP_0009733 . obo:HP_0002890 obo:IAO_0000115 "The presence of a carcinoma of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D013964", "NCIT:C2916", "UMLS:C0549473" ; oboInOwl:id "HP:0002890" ; a owl:Class ; rdfs:label "Thyroid carcinoma" ; rdfs:subClassOf obo:HP_0100031 . obo:HP_0002891 obo:IAO_0000115 "The presence of a leiomyosarcoma of the uterus." ; oboInOwl:hasDbXref "NCIT:C3158", "SNOMEDCT_US:447389009", "UMLS:C0280631" ; oboInOwl:id "HP:0002891" ; a owl:Class ; rdfs:comment "Leiomyosarcoma is a malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells [MPATH]." ; rdfs:label "Uterine leiomyosarcoma" ; rdfs:subClassOf obo:HP_0010784, obo:HP_0100243 . obo:HP_0002893 obo:IAO_0000115 "A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary)." ; oboInOwl:hasDbXref "ICD-O:M8272/0", "MSH:D010911", "NCIT:C2855", "SNOMEDCT_US:128664001", "SNOMEDCT_US:254956000", "UMLS:C0032000" ; oboInOwl:hasExactSynonym "Noncancerous tumor in pituitary gland", "Noncancerous tumour in pituitary gland", "Pituitary gland adenoma" ; oboInOwl:id "HP:0002893" ; a owl:Class ; rdfs:comment "In most cases pituitary adenoma are histologically benign, slow-growing, small neoplasms confined to the sella turcica. Some pituitary adenomas are more aggressive, grow faster, invade surrounding tissues, and cause local symptoms such as visual disturbances, headache, and varying degrees of hypopituitarism. Pituitary adenoma can be described as microadenoma, macroadenoma, and giant tumors based on size. Microadenoma is a tumor less than 10 mm, while macroadenoma describes a tumor larger than 10mm. Giant pituitary tumors are bigger than 40 mm." ; rdfs:label "Pituitary adenoma" ; rdfs:subClassOf obo:HP_0011750 . obo:HP_0002894 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the pancreas." ; oboInOwl:hasAlternativeId "HP:0004511" ; oboInOwl:hasBroadSynonym "Cancer of the pancreas", "Pancreatic cancer" ; oboInOwl:hasDbXref "MSH:D010190", "NCIT:C3262", "SNOMEDCT_US:126859007", "SNOMEDCT_US:363418001", "UMLS:C0030297", "UMLS:C0346647", "UMLS:C1842408" ; oboInOwl:hasExactSynonym "Neoplasia of the pancreas", "Pancreatic tumor", "Pancreatic tumour" ; oboInOwl:hasRelatedSynonym "increased risk of pancreatic cancer" ; oboInOwl:id "HP:0002894" ; a owl:Class ; rdfs:label "Neoplasm of the pancreas" ; rdfs:subClassOf obo:HP_0001732, obo:HP_0011793 . obo:HP_0002895 obo:IAO_0000115 "The presence of a papillary adenocarcinoma of the thyroid gland." ; oboInOwl:hasDbXref "MSH:C536915", "NCIT:C2853", "SNOMEDCT_US:255029007", "UMLS:C0238463" ; oboInOwl:hasExactSynonym "Papillary carcinoma of thyroid", "Thyroid papillary carcinoma" ; oboInOwl:id "HP:0002895" ; a owl:Class ; rdfs:label "Papillary thyroid carcinoma" ; rdfs:subClassOf obo:HP_0002890 . obo:HP_0002896 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the liver." ; oboInOwl:hasDbXref "MSH:D008113", "NCIT:C3262", "SNOMEDCT_US:126851005", "SNOMEDCT_US:93870000", "UMLS:C0023903", "UMLS:C0345904" ; oboInOwl:hasExactSynonym "Liver cancer", "Liver tumor", "Liver tumour" ; oboInOwl:id "HP:0002896" ; a owl:Class ; rdfs:label "Neoplasm of the liver" ; rdfs:subClassOf obo:HP_0001392, obo:HP_0007378 . obo:HP_0002897 obo:IAO_0000115 "A benign tumor of the parathyroid gland that can cause hyperparathyroidism." ; oboInOwl:hasAlternativeId "HP:0008257" ; oboInOwl:hasDbXref "ICD-10:D35.1", "MSH:D010282", "NCIT:C2855", "SNOMEDCT_US:128474007", "UMLS:C0262587" ; oboInOwl:hasExactSynonym "Parathyroid adenomas" ; oboInOwl:id "HP:0002897" ; a owl:Class ; rdfs:label "Parathyroid adenoma" ; rdfs:subClassOf obo:HP_0100733 . obo:HP_0002898 oboInOwl:hasDbXref "MSH:D009373", "UMLS:C0027654" ; oboInOwl:hasExactSynonym "Embryonal neoplasia", "Embryonal tumors", "Embryonal tumours" ; oboInOwl:id "HP:0002898" ; a owl:Class ; rdfs:label "Embryonal neoplasm" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0002900 obo:IAO_0000115 "An abnormally decreased potassium concentration in the blood." ; oboInOwl:hasDbXref "MSH:D007008", "SNOMEDCT_US:166690008", "SNOMEDCT_US:43339004", "UMLS:C0020621" ; oboInOwl:hasExactSynonym "Low blood potassium levels" ; oboInOwl:id "HP:0002900" ; a owl:Class ; rdfs:label "Hypokalemia" ; rdfs:subClassOf obo:HP_0011042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002901 obo:IAO_0000115 "An abnormally decreased calcium concentration in the blood." ; oboInOwl:hasDbXref "MSH:D006996", "SNOMEDCT_US:5291005", "UMLS:C0020598" ; oboInOwl:hasExactSynonym "Hypocalcaemia", "Low blood calcium levels" ; oboInOwl:id "HP:0002901" ; a owl:Class ; rdfs:label "Hypocalcemia" ; rdfs:subClassOf obo:HP_0004363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002902 obo:IAO_0000115 "An abnormally decreased sodium concentration in the blood." ; oboInOwl:hasDbXref "MSH:D007010", "SNOMEDCT_US:89627008", "UMLS:C0020625" ; oboInOwl:hasExactSynonym "Low blood sodium levels" ; oboInOwl:id "HP:0002902" ; a owl:Class ; rdfs:label "Hyponatremia" ; rdfs:subClassOf obo:HP_0010931 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002904 obo:IAO_0000115 "An increased amount of bilirubin in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:26165005", "UMLS:C0311468" ; oboInOwl:hasExactSynonym "High blood bilirubin levels" ; oboInOwl:id "HP:0002904" ; a owl:Class ; rdfs:label "Hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0033479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002905 obo:IAO_0000115 "An abnormally increased phosphate concentration in the blood." ; oboInOwl:hasDbXref "MSH:D054559", "SNOMEDCT_US:20165001", "UMLS:C0085681", "UMLS:C0553706" ; oboInOwl:hasExactSynonym "High blood phosphate levels" ; oboInOwl:id "HP:0002905" ; a owl:Class ; rdfs:label "Hyperphosphatemia" ; rdfs:subClassOf obo:HP_0100529 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002907 obo:IAO_0000115 "Microscopic hematuria detected by dipstick or microscopic examination of the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:197940006", "UMLS:C0239937" ; oboInOwl:hasExactSynonym "Microhematuria", "Occult hematuria", "Small amount of blood in urine" ; oboInOwl:id "HP:0002907" ; a owl:Class ; rdfs:label "Microscopic hematuria" ; rdfs:subClassOf obo:HP_0000790 . obo:HP_0002908 oboInOwl:hasAlternativeId "HP:0008351" ; oboInOwl:hasDbXref "SNOMEDCT_US:9326001", "UMLS:C0268307" ; oboInOwl:hasExactSynonym "Direct hyperbilirubinemia" ; oboInOwl:id "HP:0002908" ; a owl:Class ; rdfs:label "Conjugated hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0002904 . obo:HP_0002909 obo:IAO_0000115 "An increased concentration of all types of amino acid in the urine." ; oboInOwl:hasAlternativeId "HP:0008284", "HP:0008317" ; oboInOwl:hasDbXref "UMLS:C1847868" ; oboInOwl:hasExactSynonym "Generalised aminoaciduria", "Generalised nonspecific aminoaciduria", "Generalized nonspecific aminoaciduria" ; oboInOwl:id "HP:0002909" ; a owl:Class ; rdfs:comment "This abnormality is distinct from aminoacidurias in which the urinary concentration of a single amino acid, or a of single group of amino acids, is increased." ; rdfs:label "Generalized aminoaciduria" ; rdfs:subClassOf obo:HP_0003355 . obo:HP_0002910 obo:IAO_0000115 "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." ; oboInOwl:hasAlternativeId "HP:0001411", "HP:0003143", "HP:0003156", "HP:0003293", "HP:0006567", "HP:0006578", "HP:0008267", "HP:0008342" ; oboInOwl:hasDbXref "MSH:D008107", "SNOMEDCT_US:166603001", "SNOMEDCT_US:166643006", "SNOMEDCT_US:75183008", "UMLS:C0086565", "UMLS:C0151766", "UMLS:C0235996", "UMLS:C0438237", "UMLS:C0438717", "UMLS:C0877359", "UMLS:C1842003", "UMLS:C1848701" ; oboInOwl:hasExactSynonym "Abnormal liver enzymes", "Abnormal liver function", "Abnormal liver function tests", "Elevated liver enzymes", "Elevated serum transaminases", "Elevated transaminases", "High liver enzymes", "Increased liver enzymes", "Increased liver function tests", "Increased transaminases", "Raised liver enzymes", "Subclinical abnormal liver function tests" ; oboInOwl:hasRelatedSynonym "Elevated liver function tests" ; oboInOwl:id "HP:0002910" ; a owl:Class ; rdfs:label "Elevated hepatic transaminase" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001162 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002912 obo:IAO_0000115 "Increased concentration of methylmalonic acid in the blood." ; oboInOwl:hasAlternativeId "HP:0003123", "HP:0008295" ; oboInOwl:hasDbXref "MSH:C537358", "SNOMEDCT_US:42393006", "UMLS:C0268583" ; oboInOwl:hasExactSynonym "Elevated circulating methylmalonic acid concentration" ; oboInOwl:id "HP:0002912" ; a owl:Class ; rdfs:comment "Methylmalonic aciduria is a genetically heterogeneous disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism." ; rdfs:label "Methylmalonic acidemia" ; rdfs:subClassOf obo:HP_0004341, obo:HP_0010995, obo:HP_0032368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002913 obo:IAO_0000115 "Presence of myoglobin in the urine." ; oboInOwl:hasDbXref "MSH:D009212", "SNOMEDCT_US:48165008", "UMLS:C0027080" ; oboInOwl:id "HP:0002913" ; a owl:Class ; rdfs:comment "Myoglobinuria is usually associated with rhabdomyolysis or muscle destruction." ; rdfs:label "Myoglobinuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_7044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002914 obo:IAO_0000115 "An increased concentration of chloride in the urine." ; oboInOwl:hasDbXref "UMLS:C1846352" ; oboInOwl:hasExactSynonym "Increased urinary chloride" ; oboInOwl:id "HP:0002914" ; a owl:Class ; rdfs:label "Hyperchloriduria" ; rdfs:subClassOf obo:HP_0012600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002916 obo:IAO_0000115 "An abnormality of chromosome segregation." ; oboInOwl:hasDbXref "UMLS:C4025670" ; oboInOwl:id "HP:0002916" ; a owl:Class ; rdfs:label "Abnormality of chromosome segregation" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0007059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002917 obo:IAO_0000115 "An abnormally decreased magnesium concentration in the blood." ; oboInOwl:hasAlternativeId "HP:0003284" ; oboInOwl:hasDbXref "SNOMEDCT_US:190855004", "UMLS:C0151723" ; oboInOwl:hasExactSynonym "Low blood Mg levels", "Low blood magnesium levels" ; oboInOwl:id "HP:0002917" ; a owl:Class ; rdfs:label "Hypomagnesemia" ; rdfs:subClassOf obo:HP_0004921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25107 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002918 obo:IAO_0000115 "An abnormally increased magnesium concentration in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:66978005", "UMLS:C0151714" ; oboInOwl:hasExactSynonym "High blood Mg levels", "High blood magnesium levels" ; oboInOwl:id "HP:0002918" ; a owl:Class ; rdfs:label "Hypermagnesemia" ; rdfs:subClassOf obo:HP_0004921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25107 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002919 obo:IAO_0000115 "High levels of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the urine. Ketone bodies are insignificant in the blood and urine of normal individuals in the postprandial or overnight-fasted state." ; oboInOwl:hasDbXref "MSH:D007662", "SNOMEDCT_US:274783007", "SNOMEDCT_US:36815008", "UMLS:C0162275" ; oboInOwl:hasExactSynonym "Ketonaciduria", "Ketone bodies in urine" ; oboInOwl:hasRelatedSynonym "Acetonuria", "Ketoaciduria" ; oboInOwl:id "HP:0002919" ; a owl:Class ; rdfs:comment "Acetone is the main component of the ketone bodies." ; rdfs:label "Ketonuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002920 obo:IAO_0000115 "The concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), is below the lower limit of normal in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4025669" ; oboInOwl:id "HP:0002920" ; a owl:Class ; rdfs:label "Decreased circulating ACTH concentration" ; rdfs:subClassOf obo:HP_0011043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002921 obo:IAO_0000115 "An abnormality of the cerebrospinal fluid (CSF)." ; oboInOwl:hasDbXref "UMLS:C0151583" ; oboInOwl:hasExactSynonym "Abnormal CSF findings", "Abnormality of the CSF", "Abnormality of the cerebrospinal fluid" ; oboInOwl:id "HP:0002921" ; a owl:Class ; rdfs:comment "The cerebrospinal fluid (CSF) is secreted by the choroid plexus, and flows uninterrupted throughout the central nervous system (the central cerebrospinal canal of the spinal cord and through the four interconnected cerebral ventricles in the brain)." ; rdfs:label "Abnormal cerebrospinal fluid morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001359 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002922 obo:IAO_0000115 "Increased concentration of protein in the cerebrospinal fluid." ; oboInOwl:hasDbXref "UMLS:C1806780" ; oboInOwl:hasExactSynonym "Cerebrospinal fluid protein increased", "Cerebrospinal fluid with increased protein", "Elevated cerebrospinal fluid protein", "Elevated csf protein", "Hyperproteinorrhachia", "Increased CSF protein", "Increased protein in csf", "Spinal fluid protein elevated" ; oboInOwl:id "HP:0002922" ; a owl:Class ; rdfs:label "Increased CSF protein concentration" ; rdfs:subClassOf obo:HP_0025456 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002923 obo:IAO_0000115 "The presence in the serum of an autoantibody directed against the Fc portion of IgG." ; oboInOwl:hasDbXref "SNOMEDCT_US:165839004", "UMLS:C0151379" ; oboInOwl:id "HP:0002923" ; a owl:Class ; rdfs:label "Rheumatoid factor positive" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0002924 obo:IAO_0100001 "HP:0004319" ; oboInOwl:id "HP:0002924" ; a owl:Class ; rdfs:label "obsolete Decreased circulating aldosterone level" ; owl:deprecated true . obo:HP_0002925 obo:IAO_0000115 "Increased concentration of thyroid-stimulating hormone (TSH) in the blood circulation." ; oboInOwl:hasDbXref "SNOMEDCT_US:309080005", "UMLS:C0586553" ; oboInOwl:hasExactSynonym "Elevated thyroid stimulating hormone", "Elevated thyroid stimulating hormone levels", "High TSH", "Increased serum thyroid-stimulating hormone", "Increased thyroid-stimulating hormone", "Increased thyroid-stimulating hormone level", "Increased thyrotropin level", "TSH excess", "Thyroid-stimulating hormone excess" ; oboInOwl:id "HP:0002925" ; a owl:Class ; rdfs:label "Elevated circulating thyroid-stimulating hormone concentration" ; rdfs:subClassOf obo:HP_0031097 . obo:HP_0002926 obo:IAO_0000115 "An abnormal functionality of the thyroid gland." ; oboInOwl:hasDbXref "UMLS:C0857576" ; oboInOwl:hasExactSynonym "Abnormal thyroid function" ; oboInOwl:id "HP:0002926" ; a owl:Class ; rdfs:label "Abnormality of thyroid physiology" ; rdfs:subClassOf obo:HP_0000820 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002927 obo:IAO_0000115 "An increased concentration of histidine in the urine." ; oboInOwl:hasAlternativeId "HP:0010905" ; oboInOwl:hasDbXref "MSH:C538321", "SNOMEDCT_US:78311009", "UMLS:C0268642" ; oboInOwl:hasExactSynonym "Elevated histidine in urine", "High urine histidine levels" ; oboInOwl:id "HP:0002927" ; a owl:Class ; rdfs:comment "Normal urinary histidine total (free and combined form) excretion is around 190 mg per 24 hours." ; rdfs:label "Histidinuria" ; rdfs:subClassOf obo:HP_0033100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002928 oboInOwl:hasDbXref "UMLS:C1839888" ; oboInOwl:hasExactSynonym "Decreased activity of the PDH complex", "Pyruvate dehydrogenase complex deficiency" ; oboInOwl:id "HP:0002928" ; a owl:Class ; rdfs:label "Decreased activity of the pyruvate dehydrogenase complex" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0002929 oboInOwl:hasDbXref "UMLS:C4025668" ; oboInOwl:id "HP:0002929" ; a owl:Class ; rdfs:label "Leydig cell insensitivity to gonadotropin" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0002930 obo:IAO_0000115 "Reduced sensitivity of end organs to thyroid hormone characterized by elevated serum levels of free thyroid hormone with nonsuppressed thyroid stimulating hormone." ; oboInOwl:hasAlternativeId "HP:0008215", "HP:0008243", "HP:0008262" ; oboInOwl:hasDbXref "MSH:D018382", "SNOMEDCT_US:111567006", "SNOMEDCT_US:237559000", "SNOMEDCT_US:237560005", "SNOMEDCT_US:50375007", "UMLS:C2940786" ; oboInOwl:hasExactSynonym "Elevated serum levels of free thyroid hormone with nonsuppressed TSH", "End-organ unresponsiveness to thyroid hormone", "Resistance to thyroid hormone", "Thyroid hormone receptor defect", "Thyroid hormone resistance" ; oboInOwl:id "HP:0002930" ; a owl:Class ; rdfs:comment "Impaired sensitivity to thyroid hormone may be accompanied by goiter and no clear symptoms and signs of thyrotoxicosis. The etiologies of this feature include defects in the thyroid hormone receptor, reduced cellular access of the biologically active thyroid hormone, T3 related to defects of thyroid hormone cell membrane transport, and a defect reducing the intracellular metabolism generating T3 from T4." ; rdfs:label "Impaired sensitivity to thyroid hormone" ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0002932 obo:IAO_0000115 "A reduction in aldehyde oxidase level." ; oboInOwl:hasDbXref "SNOMEDCT_US:124161002", "UMLS:C1291266" ; oboInOwl:id "HP:0002932" ; a owl:Class ; rdfs:comment "Aldehyde oxidase generates carboxylic acids from aldehydes." ; rdfs:label "Aldehyde oxidase deficiency" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002933 obo:IAO_0000115 "Ventral hernia refers to a condition in which abdominal contents protrude through a weakened portion of the abdominal wall." ; oboInOwl:hasDbXref "MSH:D006555", "SNOMEDCT_US:414396006", "UMLS:C0019326" ; oboInOwl:id "HP:0002933" ; a owl:Class ; rdfs:label "Ventral hernia" ; rdfs:subClassOf obo:HP_0004299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002163 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002936 obo:IAO_0000115 "An abnormal reduction in sensation in the distal portions of the extremities." ; oboInOwl:hasAlternativeId "HP:0003476", "HP:0006843", "HP:0006845", "HP:0006922", "HP:0006971", "HP:0006993", "HP:0007138", "HP:0007292", "HP:0007296" ; oboInOwl:hasDbXref "UMLS:C1847584" ; oboInOwl:hasExactSynonym "Decreased distal sensation", "Decreased sensation in extremities", "Distal sensation loss", "Distal sensory impairment in lower limbs", "Distal sensory impairment of the lower extremities", "Distal sensory loss", "Distal sensory loss, upper and lower limbs", "Loss of distal sensation" ; oboInOwl:id "HP:0002936" ; a owl:Class ; rdfs:label "Distal sensory impairment" ; rdfs:subClassOf obo:HP_0003474 . obo:HP_0002937 obo:IAO_0000115 "Absence of one half of the vertebral body." ; oboInOwl:hasDbXref "SNOMEDCT_US:68359008", "UMLS:C0265677" ; oboInOwl:hasExactSynonym "Hemi-vertebrae", "Hemivertebra", "Missing part of vertebrae" ; oboInOwl:id "HP:0002937" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Lateral hemivertebrae represent a developmental defect resulting from the failure of the contralateral chondral center to develop. Dorsal hemivertebrae result from a developmental defect in which the anterior chondral centers fail to develop, and ventral hemivertebrae result from failure of the posterior centers to ossify. The affected half of the vertebral body may by hypoplastic or absent, as is the pedicle, and (for thoracic vetebrae) the corresponding rib. The affected half of the vertebral body may also show a fusion or segmentation defect." ; rdfs:label "Hemivertebrae" ; rdfs:subClassOf obo:HP_0003312, obo:HP_0003422 . obo:HP_0002938 obo:IAO_0000115 "An abnormal accentuation of the inward curvature of the spine in the lumbar region." ; oboInOwl:hasAlternativeId "HP:0002941", "HP:0004560", "HP:0004574", "HP:0004596" ; oboInOwl:hasDbXref "UMLS:C1184923" ; oboInOwl:hasExactSynonym "Exaggerated lumbar lordosis", "Excessive inward curvature of lower spine", "Increased lumbar lordosis", "Lumbar lordosis", "Prominent lumbar lordosis" ; oboInOwl:id "HP:0002938" ; a owl:Class ; rdfs:label "Lumbar hyperlordosis" ; rdfs:subClassOf obo:HP_0003307 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003307 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002942 obo:IAO_0000115 "Over curvature of the thoracic region, leading to a round back or if sever to a hump." ; oboInOwl:hasDbXref "UMLS:C1184919" ; oboInOwl:hasExactSynonym "Accentuated thoracic kyphosis", "Exaggerated thoracic kyphosis" ; oboInOwl:id "HP:0002942" ; a owl:Class ; rdfs:label "Thoracic kyphosis" ; rdfs:subClassOf obo:HP_0002808, obo:HP_0100711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002808 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002943 oboInOwl:hasAlternativeId "HP:0004615" ; oboInOwl:hasDbXref "UMLS:C1857790" ; oboInOwl:id "HP:0002943" ; a owl:Class ; rdfs:label "Thoracic scoliosis" ; rdfs:subClassOf obo:HP_0002650, obo:HP_0100711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002944 oboInOwl:hasAlternativeId "HP:0004567", "HP:0004585" ; oboInOwl:hasDbXref "UMLS:C0749379" ; oboInOwl:hasExactSynonym "Scoliosis, thoracolumbar" ; oboInOwl:id "HP:0002944" ; a owl:Class ; rdfs:label "Thoracolumbar scoliosis" ; rdfs:subClassOf obo:HP_0002650 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009568 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002945 obo:IAO_0000115 "Decreased height of the intervertebral disk." ; oboInOwl:hasDbXref "SNOMEDCT_US:11301007", "UMLS:C0263870" ; oboInOwl:hasExactSynonym "Narrow intervertebral disc spaces", "Narrow intervertebral spaces" ; oboInOwl:id "HP:0002945" ; a owl:Class ; rdfs:comment "A decrease in the height of the intervertebral disks is usually observed as a narrowing of the space between the vertebrae on X-ray examination." ; rdfs:label "Intervertebral space narrowing" ; rdfs:subClassOf obo:HP_0005108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000569 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002946 oboInOwl:hasDbXref "SNOMEDCT_US:87294007", "UMLS:C0265681" ; oboInOwl:id "HP:0002946" ; a owl:Class ; rdfs:label "Supernumerary vertebrae" ; rdfs:subClassOf obo:HP_0009144, obo:HP_0030304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002947 obo:IAO_0000115 "Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance." ; oboInOwl:hasDbXref "SNOMEDCT_US:298393001", "UMLS:C0575170" ; oboInOwl:hasExactSynonym "Rounded neck" ; oboInOwl:id "HP:0002947" ; a owl:Class ; rdfs:label "Cervical kyphosis" ; rdfs:subClassOf obo:HP_0002808, obo:HP_0005905 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002808 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0002948 obo:IAO_0000115 "A developmental defect leading to the union of two adjacent vertebrae." ; oboInOwl:hasAlternativeId "HP:0002807", "HP:0008471", "HP:0008485" ; oboInOwl:hasDbXref "UMLS:C1835763", "UMLS:C1849073", "UMLS:C3278509" ; oboInOwl:hasExactSynonym "Fused vertebrae", "Fusion of vertebral bodies", "Spinal fusion", "Vertebral body fusion" ; oboInOwl:id "HP:0002948" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vertebral fusion" ; rdfs:subClassOf obo:HP_0003422, obo:HP_0100240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002949 obo:IAO_0000115 "A congenital anomaly characterized by a joining (fusion) of two or more cervical vertebral bodies with one another." ; oboInOwl:hasDbXref "UMLS:C3887527" ; oboInOwl:hasExactSynonym "Cervical spine fusion", "Cervical vertebral fusion", "Fused neck", "Fusion of cervical vertebrae" ; oboInOwl:id "HP:0002949" ; a owl:Class ; rdfs:label "Fused cervical vertebrae" ; rdfs:subClassOf obo:HP_0002948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002951 obo:IAO_0000115 "Congenital absence of a part of the vermis of cerebellum." ; oboInOwl:hasDbXref "UMLS:C4025667" ; oboInOwl:id "HP:0002951" ; a owl:Class ; rdfs:label "Partial absence of cerebellar vermis" ; rdfs:subClassOf obo:HP_0006817 . obo:HP_0002953 oboInOwl:hasDbXref "SNOMEDCT_US:42942008", "SNOMEDCT_US:84138006", "UMLS:C0262431", "UMLS:C0410550" ; oboInOwl:hasExactSynonym "Compression fracture of a vertebral body", "Fractures of vertebral bodies", "Vertebral body compression", "Vertebral collapse", "Vertebral compression", "Vertebral compression fractures", "Vertebral compression or collapse" ; oboInOwl:id "HP:0002953" ; a owl:Class ; rdfs:label "Vertebral compression fracture" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0002955 obo:IAO_0000115 "A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity." ; oboInOwl:hasDbXref "SNOMEDCT_US:443138004", "SNOMEDCT_US:44328006", "UMLS:C0521173" ; oboInOwl:id "HP:0002955" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by tissue biopsy. A granuloma is a compact (organized) collection of mature mononuclear phagocytes (macrophages and/or epithelioid cells) which may or may not be accompanied by accessory features such as necrosis or the infiltration of other inflammatory leukocytes (Adams DO. The granulomatous inflammatory response. Am J Pathol 1976:84:163-192)." ; rdfs:label "Granulomatosis" ; rdfs:subClassOf obo:HP_0004311 . obo:HP_0002958 obo:IAO_0000115 "Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications." ; oboInOwl:hasDbXref "UMLS:C1844666" ; oboInOwl:hasExactSynonym "Immune dysregulation", "Unregulated immune response" ; oboInOwl:id "HP:0002958" ; a owl:Class ; rdfs:label "Immune dysregulation" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0002959 obo:IAO_0000115 "An impairment of the class-switch recombination process that normally leads B lymphocytes to produce IgG, IgA, or IgE." ; oboInOwl:hasDbXref "UMLS:C1842528" ; oboInOwl:hasExactSynonym "Impaired B-lymphocyte isotype switching" ; oboInOwl:id "HP:0002959" ; a owl:Class ; rdfs:comment "The generation of the antibody repertoire requires two successive steps. The first is antigen- and T-cell-independent; it takes place in the fetal liver and the bone marrow. Immature B lymphocytes rearrange their immunoglobulin-gene variable segments (V segments), diversity segments (D segments) and joining segments (J segments), producing a functionally integrated VDJ segment linked to the mu constant region (C-mu), which determines the primary antibody repertoire composed of IgM antibodies. The second step is antigen- and T-cell-dependent and takes place in secondary lymphoid organs. After encountering antigen, B cells proliferate and form germinal centers. In this unique anatomic formation, two genetic events lead to generation of the secondary antibody repertoire: class-switch recombination (CSR) and somatic hypermutation (SHM). CSR of immunoglobulins occurs by a recombination process between two different switch regions (S regions) located upstream of each C region. Replacement of C-mu by a constant region of another class of immunoglobulin (C-gamma, C-alpha or C-epsilon) ensues and leads to the production of IgG, IgA or IgE." ; rdfs:label "Impaired Ig class switch recombination" ; rdfs:subClassOf obo:HP_0005372 . obo:HP_0002960 obo:IAO_0000115 "The occurrence of an immune reaction against the organism's own cells or tissues." ; oboInOwl:hasDbXref "MSH:D001327", "SNOMEDCT_US:85828009", "UMLS:C0004364" ; oboInOwl:hasExactSynonym "Autoimmune condition", "Autoimmune disease", "Autoimmune disorder", "Autoimmunity" ; oboInOwl:id "HP:0002960" ; a owl:Class ; rdfs:label "Autoimmunity" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_346 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002961 obo:IAO_0000115 "Selective deficiency of one or more, but not all, classes of immunoglobulins." ; oboInOwl:hasDbXref "MSH:D004406", "SNOMEDCT_US:123782009", "UMLS:C0013374" ; oboInOwl:id "HP:0002961" ; a owl:Class ; rdfs:label "Dysgammaglobulinemia" ; rdfs:subClassOf obo:HP_0004313 . obo:HP_0002963 obo:IAO_0000115 "Delay in cutaneous immune reaction to specific antigens mediated not by antibodies but by cells. The delayed hypersensitivity test is an immune function test measuring the presence of activated T cells that recognize a specific antigen and is performed by injecting a small amount of the antigen into the skin. The area of the injection is examined 48-72 hours thereafter." ; oboInOwl:hasDbXref "UMLS:C1833172" ; oboInOwl:id "HP:0002963" ; a owl:Class ; rdfs:comment "This is an immune function test measuring the presence of activated T cells that recognize a certain substance." ; rdfs:label "Abnormal delayed hypersensitivity skin test" ; rdfs:subClassOf obo:HP_0011840 . obo:HP_0002965 obo:IAO_0000115 "Inability to react to a delayed hypersensitivity skin test." ; oboInOwl:hasAlternativeId "HP:0005427" ; oboInOwl:hasDbXref "UMLS:C1855781" ; oboInOwl:hasExactSynonym "Absence of delayed hypersensitivity skin test", "Lack of delayed skin hypersensitivity reaction" ; oboInOwl:id "HP:0002965" ; a owl:Class ; rdfs:comment "Anergy skin testing assesses the responses to skin-test antigens to which a cell-mediated, delayed-type hypersensitivity (DTH) response is expected." ; rdfs:label "Cutaneous anergy" ; rdfs:subClassOf obo:HP_0002963 . obo:HP_0002967 obo:IAO_0000115 "Abnormal positioning in which the elbows are turned out." ; oboInOwl:hasDbXref "SNOMEDCT_US:54583007", "UMLS:C0158465" ; oboInOwl:hasExactSynonym "Outward turned elbows" ; oboInOwl:id "HP:0002967" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cubitus valgus" ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0002970 obo:IAO_0000115 "A positional abnormality marked by outward bowing of the legs in which the knees stay wide apart when a person stands with the feet and ankles together." ; oboInOwl:hasAlternativeId "HP:0003052" ; oboInOwl:hasDbXref "MSH:D056305", "SNOMEDCT_US:299331007", "UMLS:C0544755" ; oboInOwl:hasExactSynonym "Genu vara", "Genua vara", "Outward bow-leggedness", "Outward bowing at knees" ; oboInOwl:id "HP:0002970" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Genu varum" ; rdfs:subClassOf obo:HP_0002979, obo:HP_0034669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001649 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002971 obo:IAO_0000115 "Absence of the fingerlike protrusive, actin-dependent structures found on the surface of peripheral blood lymphocytes." ; oboInOwl:hasDbXref "UMLS:C1833173" ; oboInOwl:id "HP:0002971" ; a owl:Class ; rdfs:label "Absent microvilli on the surface of peripheral blood lymphocytes" ; rdfs:subClassOf obo:HP_0004332 . obo:HP_0002972 obo:IAO_0000115 "Decreased ability to react to a delayed hypersensitivity skin test." ; oboInOwl:hasAlternativeId "HP:0005434" ; oboInOwl:hasDbXref "UMLS:C1843386" ; oboInOwl:hasExactSynonym "Decreased reactivity to skin test antigens", "Deficiency of delayed skin hypersensitivity", "Impaired delayed hypersensitivity" ; oboInOwl:id "HP:0002972" ; a owl:Class ; rdfs:label "Reduced delayed hypersensitivity" ; rdfs:subClassOf obo:HP_0002963 . obo:HP_0002973 obo:IAO_0000115 "An abnormality of the lower arm." ; oboInOwl:hasDbXref "UMLS:C4025666" ; oboInOwl:hasExactSynonym "Abnormality of the forearm" ; oboInOwl:id "HP:0002973" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal forearm morphology" ; rdfs:subClassOf obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002974 obo:IAO_0000115 "An abnormal osseous union (fusion) between the radius and the ulna." ; oboInOwl:hasAlternativeId "HP:0003962" ; oboInOwl:hasDbXref "MEDDRA:10037798", "MSH:C562408", "SNOMEDCT_US:33313004", "UMLS:C0158761" ; oboInOwl:hasExactSynonym "Fused forearm bones" ; oboInOwl:id "HP:0002974" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Radioulnar synostosis" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0040071, obo:HP_0100238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002977 obo:IAO_0000115 "Absence or underdevelopment of tissue in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:13:00Z" ; oboInOwl:hasAlternativeId "HP:0001323" ; oboInOwl:hasDbXref "UMLS:C4025665" ; oboInOwl:hasExactSynonym "Absent/underdeveloped central nervous system tissue", "Aplasia/Hypoplasia involving the CNS" ; oboInOwl:id "HP:0002977" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the central nervous system" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002979 obo:IAO_0000115 "A bending or abnormal curvature affecting a long bone of the leg." ; oboInOwl:hasAlternativeId "HP:0006428" ; oboInOwl:hasDbXref "MSH:D056305", "SNOMEDCT_US:299331007", "UMLS:C0544755" ; oboInOwl:hasExactSynonym "Bow legs", "Bow-leggedness", "Bowed legs", "Bowed lower limbs" ; oboInOwl:id "HP:0002979" ; a owl:Class ; rdfs:label "Bowing of the legs" ; rdfs:subClassOf obo:HP_0002981, obo:HP_0006487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002980 obo:IAO_0000115 "Bowing (abnormal curvature) of the femur." ; oboInOwl:hasAlternativeId "HP:0004998" ; oboInOwl:hasDbXref "UMLS:C1859461" ; oboInOwl:hasExactSynonym "Bowed femur", "Bowed femura", "Bowed femurs", "Bowed thighbone" ; oboInOwl:id "HP:0002980" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Femoral bowing" ; rdfs:subClassOf obo:HP_0002823, obo:HP_0002979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002981 obo:IAO_0000115 "An abnormality of the calf, i.e. of the posterior part of the lower leg." ; oboInOwl:hasDbXref "UMLS:C4021832" ; oboInOwl:hasExactSynonym "Abnormality of the calf" ; oboInOwl:id "HP:0002981" ; a owl:Class ; rdfs:label "Abnormality of the calf" ; rdfs:subClassOf obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002982 obo:IAO_0000115 "A bending or abnormal curvature of the tibia." ; oboInOwl:hasAlternativeId "HP:0006363" ; oboInOwl:hasDbXref "UMLS:C1837081" ; oboInOwl:hasExactSynonym "Bowed shankbone", "Bowed shinbone", "Bowed tibia", "Bowing of the tibia" ; oboInOwl:id "HP:0002982" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A developmental defect with posteromedial tibial angulation." ; rdfs:label "Tibial bowing" ; rdfs:subClassOf obo:HP_0002979, obo:HP_0002992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002983 obo:IAO_0000115 "The presence of abnormally small extremities." ; oboInOwl:hasAlternativeId "HP:0003030", "HP:0005753" ; oboInOwl:hasDbXref "MEDDRA:10027546", "SNOMEDCT_US:74370006", "UMLS:C0025995" ; oboInOwl:hasExactSynonym "Smaller or shorter than typical limbs" ; oboInOwl:id "HP:0002983" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Micromelia" ; rdfs:subClassOf obo:HP_0009826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002984 obo:IAO_0000115 "Underdevelopment of the radius." ; oboInOwl:hasAlternativeId "HP:0002995", "HP:0004989", "HP:0005014", "HP:0005081", "HP:0005714", "HP:0006418" ; oboInOwl:hasDbXref "SNOMEDCT_US:205170001", "SNOMEDCT_US:93288001", "UMLS:C0685381", "UMLS:C1840087" ; oboInOwl:hasExactSynonym "Hypoplastic radii", "Hypoplastic radius", "Radial hypoplasia", "Short radii", "Short radius", "Shortening of radius", "Underdeveloped outer large forearm bone" ; oboInOwl:hasRelatedSynonym "Radial ray hypoplasia" ; oboInOwl:id "HP:0002984" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0006501, obo:HP_0009821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002986 obo:IAO_0000115 "A bending or abnormal curvature of the radius." ; oboInOwl:hasAlternativeId "HP:0004996" ; oboInOwl:hasDbXref "UMLS:C1859399" ; oboInOwl:hasExactSynonym "Bowed radii", "Bowed radius", "Bowing of outer large bone of the forearm", "Bowing of radius bone of the forearm" ; oboInOwl:id "HP:0002986" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Radial bowing" ; rdfs:subClassOf obo:HP_0003956, obo:HP_0045008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002987 obo:IAO_0000115 "An elbow contracture that limits the ability of the elbow joint to be extended (straightened), meaning that the elbow is fixed in an flexed (bent) position." ; oboInOwl:hasAlternativeId "HP:0003937", "HP:0004984", "HP:0005654" ; oboInOwl:hasDbXref "SNOMEDCT_US:202271004", "UMLS:C0409338" ; oboInOwl:hasExactSynonym "Elbow flexion contractures", "Elbow flexion deformity", "Fixed flexion at the elbow joint" ; oboInOwl:id "HP:0002987" ; a owl:Class ; rdfs:label "Elbow flexion contracture" ; rdfs:subClassOf obo:HP_0002996, obo:HP_0034391 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002990 obo:IAO_0000115 "Absence of the fibula." ; oboInOwl:hasAlternativeId "HP:0006373" ; oboInOwl:hasDbXref "MEDDRA:10054882", "UMLS:C1836186" ; oboInOwl:hasExactSynonym "Absent calf bone", "Absent fibulae", "Absent-hypoplastic fibulae" ; oboInOwl:id "HP:0002990" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fibular aplasia" ; rdfs:subClassOf obo:HP_0006492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002991 obo:IAO_0000115 "An anomaly of the calf bone (fibula), one of the two bones of the calf." ; oboInOwl:hasDbXref "UMLS:C4025664" ; oboInOwl:hasExactSynonym "Abnormality of the calf bone" ; oboInOwl:id "HP:0002991" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of fibula morphology" ; rdfs:subClassOf obo:HP_0002981, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002992 obo:IAO_0000115 "Abnormality of the tibia (shinbone)." ; oboInOwl:hasDbXref "UMLS:C4025663" ; oboInOwl:hasExactSynonym "Abnormality of the shankbone", "Abnormality of the shinbone" ; oboInOwl:id "HP:0002992" ; a owl:Class ; rdfs:label "Abnormality of tibia morphology" ; rdfs:subClassOf obo:HP_0002981, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0002996 oboInOwl:hasAlternativeId "HP:0006395" ; oboInOwl:hasDbXref "UMLS:C1849955" ; oboInOwl:hasExactSynonym "Decreased elbow mobility", "Limited elbow mobility", "Limited elbow movement", "Restricted elbow motion" ; oboInOwl:id "HP:0002996" ; a owl:Class ; rdfs:label "Limited elbow movement" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0009811 . obo:HP_0002997 obo:IAO_0100001 "HP:0040071" ; oboInOwl:id "HP:0002997" ; a owl:Class ; rdfs:label "obsolete Abnormality of the ulna" ; owl:deprecated true . obo:HP_0002999 obo:IAO_0000115 "The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar dislocation occurs if the patella fully dislocates out of the groove." ; oboInOwl:hasDbXref "MSH:D031222", "SNOMEDCT_US:263029007", "UMLS:C1135812" ; oboInOwl:hasExactSynonym "Dislocated kneecap", "Dislocated patellae", "Dislocation of patella" ; oboInOwl:id "HP:0002999" ; a owl:Class ; rdfs:label "Patellar dislocation" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0030311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003001 oboInOwl:hasDbXref "MSH:D005925", "SNOMEDCT_US:127030001", "SNOMEDCT_US:32037004", "UMLS:C0017671" ; oboInOwl:hasExactSynonym "Glomus jugular tumour", "Glomus jugulare tumor", "Glomus jugulare tumors", "Glomus jugulare tumour", "Glomus jugulare tumours" ; oboInOwl:id "HP:0003001" ; a owl:Class ; rdfs:label "Glomus jugular tumor" ; rdfs:subClassOf obo:HP_0002864 . obo:HP_0003002 obo:IAO_0000115 "The presence of a carcinoma of the breast." ; oboInOwl:hasDbXref "MSH:D001943", "NCIT:C2916", "SNOMEDCT_US:254838004", "UMLS:C0678222" ; oboInOwl:hasExactSynonym "Breast cancer" ; oboInOwl:id "HP:0003002" ; a owl:Class ; rdfs:label "Breast carcinoma" ; rdfs:subClassOf obo:HP_0100013 . obo:HP_0003003 oboInOwl:hasAlternativeId "HP:0006718" ; oboInOwl:hasDbXref "MSH:D003110", "SNOMEDCT_US:363406005", "UMLS:C0007102" ; oboInOwl:hasExactSynonym "Colon cancer" ; oboInOwl:id "HP:0003003" ; a owl:Class ; rdfs:label "Colon cancer" ; rdfs:subClassOf obo:HP_0100273 . obo:HP_0003005 obo:IAO_0000115 "A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum, representing a tumor of the sympathetic nerve fibers arising from neural crest cells." ; oboInOwl:hasDbXref "MSH:D005729", "SNOMEDCT_US:116371000119107", "SNOMEDCT_US:128919000", "SNOMEDCT_US:53801007", "UMLS:C0017075" ; oboInOwl:id "HP:0003005" ; a owl:Class ; rdfs:comment "Ganglioneuromas and ganglioneuroblastomas are tumors of the sympathetic nervous system. They originate from neural crest sympathogonia, which are completely undifferentiated cells of the sympathetic nervous system." ; rdfs:label "Ganglioneuroma" ; rdfs:subClassOf obo:HP_0030450 . obo:HP_0003006 obo:IAO_0000115 "Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum." ; oboInOwl:hasAlternativeId "HP:0006738" ; oboInOwl:hasDbXref "MSH:D009447", "NCIT:C3270", "SNOMEDCT_US:432328008", "SNOMEDCT_US:87364003", "UMLS:C0027819" ; oboInOwl:hasExactSynonym "Cancer of early nerve cells" ; oboInOwl:id "HP:0003006" ; a owl:Class ; rdfs:label "Neuroblastoma" ; rdfs:subClassOf obo:HP_0004376, obo:HP_0030067 . obo:HP_0003009 oboInOwl:hasDbXref "UMLS:C4025661" ; oboInOwl:id "HP:0003009" ; a owl:Class ; rdfs:label "Enhanced neurotoxicity of vincristine" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0003010 obo:IAO_0000115 "Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding." ; oboInOwl:hasAlternativeId "HP:0008294", "HP:0008337" ; oboInOwl:hasDbXref "UMLS:C0151529" ; oboInOwl:hasExactSynonym "Increased bleeding time", "Prolonged bleeding time" ; oboInOwl:id "HP:0003010" ; a owl:Class ; rdfs:comment "The bleeding time test measures the time taken for blood vessel constriction and platelet plug formation to occur. No clot is allowed to form, so that the arrest of bleeding depends exclusively on blood vessel constriction and platelet action. To perform the test, pressure is maintained throughout the test by inflating a sphygmomanometer cuff on the upper arm. The dorsal surface of the forearm is then cleaned, and the bleeding time device placed onto the skin and the trigger is depressed. At 30-second intervals, the flow of blood is blotted with filter paper. The time from puncture to cessation of bleeding is then recorded as the bleeding time. Normal values depend on the device used and other parameters, but are around 2 to 9 minutes." ; rdfs:label "Prolonged bleeding time" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0003011 obo:IAO_0000115 "Abnormality originating in one or more muscles, i.e., of the set of muscles of body." ; oboInOwl:hasAlternativeId "HP:0003197", "HP:0003708", "HP:0040290" ; oboInOwl:hasDbXref "UMLS:C4021745" ; oboInOwl:hasExactSynonym "Muscular abnormality" ; oboInOwl:id "HP:0003011" ; a owl:Class ; rdfs:label "Abnormality of the musculature" ; rdfs:subClassOf obo:HP_0033127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003013 obo:IAO_0000115 "A morphological abnormality of epiphyses whereby they are abnormally outwardly curving (protuberant)." ; oboInOwl:hasDbXref "UMLS:C1833329" ; oboInOwl:hasExactSynonym "Bulging end part of bone" ; oboInOwl:id "HP:0003013" ; a owl:Class ; rdfs:label "Bulging epiphyses" ; rdfs:subClassOf obo:HP_0010580 . obo:HP_0003015 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones." ; oboInOwl:hasAlternativeId "HP:0000945", "HP:0003047", "HP:0004994", "HP:0005015", "HP:0005095", "HP:0200002" ; oboInOwl:hasDbXref "UMLS:C1850135" ; oboInOwl:hasExactSynonym "Flared wide portion of long bone", "Flared, widened metaphyses", "Metaphyseal flaring", "Metaphyseal flaring of long bones", "Metaphyseal splaying", "Metaphyses flared", "Splayed metaphyses", "marked metaphyseal flaring of long bones" ; oboInOwl:id "HP:0003015" ; a owl:Class ; rdfs:comment "Figure 11 of PMID:12853662 shows metaphyseal flaring." ; rdfs:label "Flared metaphysis" ; rdfs:subClassOf obo:HP_0003016 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003016 obo:IAO_0000115 "Abnormal widening of the metaphyseal regions of long bones." ; oboInOwl:hasAlternativeId "HP:0005074" ; oboInOwl:hasDbXref "UMLS:C1849039" ; oboInOwl:hasExactSynonym "Broad wide portion of long bone", "Wide metaphyses", "Widened long bone metaphyses", "Widened metaphyses" ; oboInOwl:id "HP:0003016" ; a owl:Class ; rdfs:label "Metaphyseal widening" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003019 obo:IAO_0000115 "Abnormality of the wrist, the structure connecting the hand and the forearm." ; oboInOwl:hasAlternativeId "HP:0001224" ; oboInOwl:hasDbXref "UMLS:C4021744" ; oboInOwl:hasExactSynonym "Abnormalities of the wrists", "Abnormality of the wrist" ; oboInOwl:id "HP:0003019" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the wrist" ; rdfs:subClassOf obo:HP_0009810 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003020 oboInOwl:hasDbXref "UMLS:C1838663" ; oboInOwl:hasExactSynonym "Enlargement of the wrists" ; oboInOwl:id "HP:0003020" ; a owl:Class ; rdfs:label "Enlargement of the wrists" ; rdfs:subClassOf obo:HP_0003019 . obo:HP_0003021 obo:IAO_0000115 "Metaphyseal cupping refers to an inward bulging of the metaphyseal profile giving the metaphysis a cup-like appearance." ; oboInOwl:hasDbXref "UMLS:C1837082" ; oboInOwl:id "HP:0003021" ; a owl:Class ; rdfs:label "Metaphyseal cupping" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0003022 obo:IAO_0000115 "Underdevelopment of the ulna." ; oboInOwl:hasAlternativeId "HP:0002998", "HP:0005842", "HP:0006388", "HP:0006444" ; oboInOwl:hasDbXref "MSH:C538069", "UMLS:C1860614", "UMLS:C1862132" ; oboInOwl:hasExactSynonym "Hypoplastic ulna", "Short ulna", "Short ulnae", "Ulnar hypoplasia", "Underdeveloped inner large forearm bone", "Underdeveloped ulna" ; oboInOwl:id "HP:0003022" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the ulna" ; rdfs:subClassOf obo:HP_0006495, obo:HP_0009821, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003023 obo:IAO_0000115 "Curvature of the shafts of the long bones due to multiple fractures." ; oboInOwl:hasDbXref "UMLS:C1850178" ; oboInOwl:hasExactSynonym "Bowed limbs due to multiple fractures" ; oboInOwl:id "HP:0003023" ; a owl:Class ; rdfs:label "Bowing of limbs due to multiple fractures" ; rdfs:subClassOf obo:HP_0002659 . obo:HP_0003025 obo:IAO_0000115 "Irregularity of the normally smooth surface of the metaphyses." ; oboInOwl:hasAlternativeId "HP:0003017", "HP:0004995", "HP:0005016", "HP:0005032", "HP:0005038", "HP:0005058", "HP:0005062", "HP:0005065", "HP:0005078", "HP:0005896" ; oboInOwl:hasDbXref "UMLS:C1838662" ; oboInOwl:hasExactSynonym "Frayed, irregular metaphyses", "Frayed, irregular, metaphyses", "Irregular metaphyses", "Irregular wide portion of a long bone", "Metaphyseal fraying", "Metaphyseal irregularities" ; oboInOwl:id "HP:0003025" ; a owl:Class ; rdfs:label "Metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003026 obo:IAO_0000115 "One or more abnormally short long bone." ; oboInOwl:hasAlternativeId "HP:0000949", "HP:0004983", "HP:0004988", "HP:0005000", "HP:0005029", "HP:0005044", "HP:0005052", "HP:0005077", "HP:0005083", "HP:0005647", "HP:0005822", "HP:0006382", "HP:0006457", "HP:0006472" ; oboInOwl:hasDbXref "UMLS:C1854912" ; oboInOwl:hasExactSynonym "Long bone shortening", "Short long bone", "Short tubular bones", "shortened long tubular bones" ; oboInOwl:id "HP:0003026" ; a owl:Class ; rdfs:comment "Long bones are also known as tubular bones." ; rdfs:label "Short long bone" ; rdfs:subClassOf obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003027 obo:IAO_0000115 "Shortening of the middle parts of the limbs (forearm and lower leg) in relation to the upper and terminal segments." ; oboInOwl:hasDbXref "UMLS:C0549306" ; oboInOwl:hasExactSynonym "Disproportionately short middle portion of limb", "Mesomelic limb shortening", "Mesomelic shortening of limbs", "Symmetric mesomelic limb shortness" ; oboInOwl:id "HP:0003027" ; a owl:Class ; rdfs:comment "Shortening of the limbs where the predominant shortness is in the middle bones." ; rdfs:label "Mesomelia" ; rdfs:subClassOf obo:HP_0009826 . obo:HP_0003028 obo:IAO_0000115 "An anomaly of the joint that connects the foot with the leg." ; oboInOwl:hasDbXref "UMLS:C4025660" ; oboInOwl:hasExactSynonym "Abnormality of the ankles" ; oboInOwl:id "HP:0003028" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the ankle" ; rdfs:subClassOf obo:HP_0100491 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003029 oboInOwl:hasDbXref "UMLS:C1838664" ; oboInOwl:hasExactSynonym "Enlargement of the ankles" ; oboInOwl:id "HP:0003029" ; a owl:Class ; rdfs:label "Enlargement of the ankles" ; rdfs:subClassOf obo:HP_0034673 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003031 obo:IAO_0000115 "Bending of the diaphysis (shaft) of the ulna." ; oboInOwl:hasAlternativeId "HP:0003983" ; oboInOwl:hasDbXref "UMLS:C1865847" ; oboInOwl:hasExactSynonym "Bowed ulna", "Curved ulna", "Curving of inner forearm bone" ; oboInOwl:id "HP:0003031" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Ulnar bowing is usually in the convex posterior direction." ; rdfs:label "Ulnar bowing" ; rdfs:subClassOf obo:HP_0003956, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003034 obo:IAO_0000115 "An elevation in bone density in one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasAlternativeId "HP:0005611" ; oboInOwl:hasDbXref "MSH:D003966", "SNOMEDCT_US:318761000119105", "SNOMEDCT_US:34643004", "UMLS:C0011989" ; oboInOwl:hasExactSynonym "Craniodiaphyseal osteosclerosis", "Diaphyseal osteosclerosis", "Increased bone density in shaft of long bone" ; oboInOwl:id "HP:0003034" ; a owl:Class ; rdfs:label "Diaphyseal sclerosis" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0006392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003037 obo:IAO_0000115 "Increase in size of one or more joints." ; oboInOwl:hasDbXref "UMLS:C1859111" ; oboInOwl:hasExactSynonym "Enlarged joints" ; oboInOwl:hasRelatedSynonym "Prominent joints" ; oboInOwl:id "HP:0003037" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Enlarged joints" ; rdfs:subClassOf obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003038 obo:IAO_0000115 "Underdevelopment of the fibula." ; oboInOwl:hasAlternativeId "HP:0002985", "HP:0005887", "HP:0006401" ; oboInOwl:hasDbXref "UMLS:C1832119" ; oboInOwl:hasExactSynonym "Hypoplastic fibula", "Short calf bone", "Short fibula", "Short fibulae" ; oboInOwl:id "HP:0003038" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fibular hypoplasia" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0006492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003040 oboInOwl:hasDbXref "MSH:D007592", "SNOMEDCT_US:399269003", "UMLS:C0022408" ; oboInOwl:hasExactSynonym "Disease of the joints" ; oboInOwl:id "HP:0003040" ; a owl:Class ; rdfs:label "Arthropathy" ; rdfs:subClassOf obo:HP_0001367 . obo:HP_0003041 obo:IAO_0000115 "An abnormal osseous union (fusion) between the radius and the humerus." ; oboInOwl:hasAlternativeId "HP:0003936" ; oboInOwl:hasDbXref "MSH:C535284", "SNOMEDCT_US:205329008", "UMLS:C1863360", "UMLS:C2930865" ; oboInOwl:hasExactSynonym "Fusion of upper and lower arm bones", "Humeral radial synostosis", "Humeral-radial synostosis", "Radiohumeral synostosis of elbow", "Synostosis of radius and humerus" ; oboInOwl:id "HP:0003041" ; a owl:Class ; rdfs:label "Humeroradial synostosis" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003063, obo:HP_0003938, obo:HP_0100744 . obo:HP_0003042 obo:IAO_0000115 "Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet." ; oboInOwl:hasAlternativeId "HP:0006411" ; oboInOwl:hasDbXref "SNOMEDCT_US:125617002", "SNOMEDCT_US:417558002", "UMLS:C1403299", "UMLS:C1403321", "UMLS:C2720437" ; oboInOwl:hasExactSynonym "Dislocations of the elbows", "Elbow dislocation", "Elbow dislocations", "Radiocapitellar dislocation", "Radiohumeral dislocation", "Ulnohumeral dislocation" ; oboInOwl:id "HP:0003042" ; a owl:Class ; rdfs:label "Elbow dislocation" ; rdfs:subClassOf obo:HP_0009811, obo:HP_0030310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003043 obo:IAO_0000115 "An abnormality of the shoulder, which is defined as the structures surrounding the shoulder joint where the humerus attaches to the scapula." ; oboInOwl:hasDbXref "UMLS:C4025659" ; oboInOwl:hasExactSynonym "Abnormality of the shoulder" ; oboInOwl:id "HP:0003043" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal shoulder morphology" ; rdfs:subClassOf obo:HP_0000765, obo:HP_0011844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003044 obo:IAO_0000115 "Chronic reduction in active and passive mobility of the shoulder joint due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." ; oboInOwl:hasDbXref "SNOMEDCT_US:202265005", "UMLS:C0409336" ; oboInOwl:id "HP:0003044" ; a owl:Class ; rdfs:label "Shoulder flexion contracture" ; rdfs:subClassOf obo:HP_0034665 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003045 obo:IAO_0000115 "Abnormality of the patella (knee cap)." ; oboInOwl:hasDbXref "UMLS:C4021743" ; oboInOwl:hasExactSynonym "Abnormal kneecap", "Abnormality of the patella", "Patellar abnormality" ; oboInOwl:id "HP:0003045" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal patella morphology" ; rdfs:subClassOf obo:HP_0034669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003048 obo:IAO_0000115 "Partial dislocation of the head of the radius." ; oboInOwl:hasDbXref "SNOMEDCT_US:417109008", "SNOMEDCT_US:95854004", "UMLS:C0149977" ; oboInOwl:hasExactSynonym "Radial subluxation", "Radial-head subluxation" ; oboInOwl:id "HP:0003048" ; a owl:Class ; rdfs:label "Radial head subluxation" ; rdfs:subClassOf obo:HP_0032153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003049 oboInOwl:hasDbXref "SNOMEDCT_US:43689004", "UMLS:C0231678" ; oboInOwl:hasExactSynonym "Ulnar deviation of wrists" ; oboInOwl:id "HP:0003049" ; a owl:Class ; rdfs:label "Ulnar deviation of the wrist" ; rdfs:subClassOf obo:HP_0003019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003051 obo:IAO_0000115 "Abnormal increase in size of one or more metaphyses." ; oboInOwl:hasAlternativeId "HP:0005018" ; oboInOwl:hasDbXref "UMLS:C1855544" ; oboInOwl:hasExactSynonym "Enlarged wide portion of a long bone" ; oboInOwl:id "HP:0003051" ; a owl:Class ; rdfs:label "Enlarged metaphyses" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003053 oboInOwl:hasDbXref "UMLS:C1854786" ; oboInOwl:id "HP:0003053" ; a owl:Class ; rdfs:label "Epiphyseal deformities of tubular bones" ; rdfs:subClassOf obo:HP_0005930 . obo:HP_0003057 obo:IAO_0000115 "Amelia of all four limbs." ; oboInOwl:hasDbXref "MSH:C536498", "SNOMEDCT_US:702313004", "UMLS:C2931216" ; oboInOwl:hasExactSynonym "Tetra-amelia" ; oboInOwl:id "HP:0003057" ; a owl:Class ; rdfs:label "Tetraamelia" ; rdfs:subClassOf obo:HP_0009827 . obo:HP_0003059 oboInOwl:hasDbXref "UMLS:C4025658" ; oboInOwl:id "HP:0003059" ; a owl:Class ; rdfs:label "Abnormality of the radioulnar joints" ; rdfs:subClassOf obo:HP_0002973 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001528 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003063 obo:IAO_0000115 "An abnormality of the humerus (i.e., upper arm bone)." ; oboInOwl:hasAlternativeId "HP:0002988" ; oboInOwl:hasDbXref "UMLS:C4021742" ; oboInOwl:hasExactSynonym "Abnormality of the humeri" ; oboInOwl:id "HP:0003063" ; a owl:Class ; rdfs:label "Abnormality of the humerus" ; rdfs:subClassOf obo:HP_0001454, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003065 obo:IAO_0000115 "Underdevelopment of the patella." ; oboInOwl:hasAlternativeId "HP:0005020" ; oboInOwl:hasDbXref "UMLS:C1840068" ; oboInOwl:hasExactSynonym "Hypoplastic patellae", "Small kneecap", "Small patella", "Small patellae", "Underdeveloped kneecap" ; oboInOwl:id "HP:0003065" ; a owl:Class ; rdfs:label "Patellar hypoplasia" ; rdfs:subClassOf obo:HP_0006498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003066 obo:IAO_0000115 "Reduced ability to extend (straighten) the knee joint." ; oboInOwl:hasDbXref "UMLS:C1844690" ; oboInOwl:hasExactSynonym "Limited knee extension" ; oboInOwl:id "HP:0003066" ; a owl:Class ; rdfs:label "Limited knee extension" ; rdfs:subClassOf obo:HP_0010501 . obo:HP_0003067 obo:IAO_0000115 "An anomaly related to partial closure, or failure of development of the ulnar side of the distal radial growth plate, which results in an arrest of epiphyseal growth of the medial and volar portions of the distal radius. This leads to shortening of the radius and relative overgrowth of the ulna." ; oboInOwl:hasDbXref "MSH:C562398", "SNOMEDCT_US:4530000", "UMLS:C0152441" ; oboInOwl:hasExactSynonym "Madelung wrist deformity" ; oboInOwl:id "HP:0003067" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Madelung deformity" ; rdfs:subClassOf obo:HP_0003019 . obo:HP_0003068 oboInOwl:hasDbXref "UMLS:C1851419" ; oboInOwl:id "HP:0003068" ; a owl:Class ; rdfs:label "Madelung-like forearm deformities" ; rdfs:subClassOf obo:HP_0002818 . obo:HP_0003070 oboInOwl:hasDbXref "SNOMEDCT_US:202307002", "UMLS:C0409477" ; oboInOwl:id "HP:0003070" ; a owl:Class ; rdfs:label "Elbow ankylosis" ; rdfs:subClassOf obo:HP_0009811, obo:HP_0031013 . obo:HP_0003071 obo:IAO_0000115 "Abnormal flatness (decreased height) of epiphyses." ; oboInOwl:hasAlternativeId "HP:0004982", "HP:0005051", "HP:0005076", "HP:0005080" ; oboInOwl:hasDbXref "UMLS:C1857527" ; oboInOwl:hasExactSynonym "Flat end part of bone", "Flat epiphyses" ; oboInOwl:id "HP:0003071" ; a owl:Class ; rdfs:label "Flattened epiphysis" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003072 obo:IAO_0000115 "An abnormally increased calcium concentration in the blood." ; oboInOwl:hasAlternativeId "HP:0008250" ; oboInOwl:hasDbXref "MSH:D006934", "SNOMEDCT_US:166702002", "SNOMEDCT_US:66931009", "UMLS:C0020437" ; oboInOwl:hasExactSynonym "High blood calcium levels", "Hypercalcaemia", "Increased calcium in blood" ; oboInOwl:id "HP:0003072" ; a owl:Class ; rdfs:label "Hypercalcemia" ; rdfs:subClassOf obo:HP_0004363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003073 obo:IAO_0000115 "Reduction in the concentration of albumin in the blood." ; oboInOwl:hasBroadSynonym "Low albumin" ; oboInOwl:hasDbXref "MSH:D034141", "SNOMEDCT_US:119247004", "UMLS:C0239981" ; oboInOwl:hasExactSynonym "Hypoalbuminaemia", "Low blood albumin" ; oboInOwl:id "HP:0003073" ; a owl:Class ; rdfs:label "Hypoalbuminemia" ; rdfs:subClassOf obo:HP_0012116 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003074 obo:IAO_0000115 "An increased concentration of glucose in the blood." ; oboInOwl:hasDbXref "MSH:D006943", "SNOMEDCT_US:237598005", "SNOMEDCT_US:80394007", "UMLS:C0020456" ; oboInOwl:hasExactSynonym "High blood glucose", "High blood sugar" ; oboInOwl:id "HP:0003074" ; a owl:Class ; rdfs:label "Hyperglycemia" ; rdfs:subClassOf obo:HP_0011015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_17234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0003075 obo:IAO_0000115 "A decreased concentration of protein in the blood." ; oboInOwl:hasDbXref "MSH:D007019", "SNOMEDCT_US:8900005", "UMLS:C0020639" ; oboInOwl:hasExactSynonym "Decreased protein levels in blood" ; oboInOwl:id "HP:0003075" ; a owl:Class ; rdfs:label "Hypoproteinemia" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16541 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003076 obo:IAO_0000115 "An increased concentration of glucose in the urine." ; oboInOwl:hasAlternativeId "HP:0003122", "HP:0011016" ; oboInOwl:hasDbXref "MSH:D006029", "SNOMEDCT_US:45154002", "UMLS:C0017979" ; oboInOwl:hasExactSynonym "Glucose in urine", "Glucosuria" ; oboInOwl:id "HP:0003076" ; a owl:Class ; rdfs:comment "Glycosuria, the excretion of abnormal amounts of glucose in the urine, generally results in osmotic diuresis." ; rdfs:label "Glycosuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17234 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003077 obo:IAO_0000115 "An elevated lipid concentration in the blood." ; oboInOwl:hasAlternativeId "HP:0008159", "HP:0008356" ; oboInOwl:hasDbXref "MSH:D006949", "SNOMEDCT_US:55822004", "UMLS:C0020473" ; oboInOwl:hasExactSynonym "Elevated lipids in blood" ; oboInOwl:id "HP:0003077" ; a owl:Class ; rdfs:comment "Hyperlipidemia is an elevation of the blood levels of lipids including primarily cholesterol, phospholipids and triglycerides and cholesterol esters. The lipids are transported on lipoproteins some of which are commonly used for clinical measurements, including chylomicrons, very-low density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins, and high-density lipoproteins (HDL)." ; rdfs:label "Hyperlipidemia" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18059 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003079 oboInOwl:hasDbXref "UMLS:C1968564" ; oboInOwl:id "HP:0003079" ; a owl:Class ; rdfs:label "Defective DNA repair after ultraviolet radiation damage" ; rdfs:subClassOf obo:HP_0003254 . obo:HP_0003080 obo:IAO_0000115 "An increased concentration of 4-hydroxy-L-proline in the urine." ; oboInOwl:hasDbXref "UMLS:C0948585" ; oboInOwl:hasExactSynonym "Elevated urinary hydroxyproline" ; oboInOwl:id "HP:0003080" ; a owl:Class ; rdfs:label "Hydroxyprolinuria" ; rdfs:subClassOf obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18240 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003081 obo:IAO_0000115 "An increased concentration of potassium(1+) in the urine." ; oboInOwl:hasDbXref "UMLS:C1846351" ; oboInOwl:hasExactSynonym "Hyperkaliuresis", "Increased urinary K", "Increased urinary potassium" ; oboInOwl:id "HP:0003081" ; a owl:Class ; rdfs:label "Increased urinary potassium" ; rdfs:subClassOf obo:HP_0012598 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003083 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint." ; oboInOwl:hasAlternativeId "HP:0002975", "HP:0005673", "HP:0005836" ; oboInOwl:hasDbXref "SNOMEDCT_US:9634000", "UMLS:C0265563" ; oboInOwl:hasExactSynonym "Congenital radial head dislocation", "Dislocated radius", "Dislocation of radial head", "Dislocation of the radial head", "Radial dislocation", "Radial head dislocation", "Radial head dislocation/subluxation" ; oboInOwl:hasRelatedSynonym "Dislocated radial heads" ; oboInOwl:id "HP:0003083" ; a owl:Class ; rdfs:label "Dislocated radial head" ; rdfs:subClassOf obo:HP_0003042, obo:HP_0003995, obo:HP_0100744 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003084 obo:IAO_0000115 "An increased tendency to fractures of the long bones (Mainly, the femur, tibia, fibula, humerus, radius, and ulna)." ; oboInOwl:hasAlternativeId "HP:0005847" ; oboInOwl:hasDbXref "UMLS:C0240231" ; oboInOwl:hasExactSynonym "Increased long bone fracture rate" ; oboInOwl:id "HP:0003084" ; a owl:Class ; rdfs:label "Fractures of the long bones" ; rdfs:subClassOf obo:HP_0002757, obo:HP_0011314, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003085 obo:IAO_0000115 "Disproportionately long fibulae." ; oboInOwl:hasDbXref "UMLS:C1848109" ; oboInOwl:hasExactSynonym "Disproportionately long fibula", "Long calf bone", "Long fibula" ; oboInOwl:id "HP:0003085" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long fibula" ; rdfs:subClassOf obo:HP_0002991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003086 obo:IAO_0000115 "Small hands and feet." ; oboInOwl:hasDbXref "UMLS:C1864365" ; oboInOwl:id "HP:0003086" ; a owl:Class ; rdfs:label "Acromesomelia" ; rdfs:subClassOf obo:HP_0003027 . obo:HP_0003088 oboInOwl:hasDbXref "UMLS:C1835121" ; oboInOwl:hasExactSynonym "Premature arthritis", "Premature osteoarthritis" ; oboInOwl:id "HP:0003088" ; a owl:Class ; rdfs:label "Premature osteoarthritis" ; rdfs:subClassOf obo:HP_0002758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000694 ] ) ] ] . obo:HP_0003089 oboInOwl:hasDbXref "SNOMEDCT_US:203074005", "UMLS:C0410266" ; oboInOwl:hasExactSynonym "Hamstring contractures" ; oboInOwl:id "HP:0003089" ; a owl:Class ; rdfs:label "Hamstring contractures" ; rdfs:subClassOf obo:HP_0005750 . obo:HP_0003090 obo:IAO_0000115 "Underdevelopment of the proximal epiphysis of the femur." ; oboInOwl:hasAlternativeId "HP:0003374", "HP:0008791", "HP:0008792" ; oboInOwl:hasDbXref "UMLS:C1839254" ; oboInOwl:hasExactSynonym "Small capital femoral epiphyses", "Small femoral capital epiphyses", "Small innermost thighbone end part", "Small proximal femoral epiphyses", "Underdevelopment of the innermost thighbone end part" ; oboInOwl:id "HP:0003090" ; a owl:Class ; rdfs:label "Hypoplasia of the capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0005003 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003091 obo:IAO_0000115 "Trophic changes occurring in a limb." ; oboInOwl:hasDbXref "UMLS:C4025657" ; oboInOwl:id "HP:0003091" ; a owl:Class ; rdfs:label "Trophic limb changes" ; rdfs:subClassOf obo:HP_0010834 . obo:HP_0003093 obo:IAO_0000115 "Limitation of the extension of the hip, i.e., decreased ability to straighten the hip joint and thereby increase the angle between torso and thigh; moving the thigh or top of the pelvis backward." ; oboInOwl:hasAlternativeId "HP:0008810" ; oboInOwl:hasDbXref "UMLS:C3553368" ; oboInOwl:hasExactSynonym "Limited hip extension", "Restricted hip extension" ; oboInOwl:id "HP:0003093" ; a owl:Class ; rdfs:comment "Reduced ability to straighten out the femur." ; rdfs:label "Limited hip extension" ; rdfs:subClassOf obo:HP_0008800 . obo:HP_0003095 dcterms:creator ; oboInOwl:hasBroadSynonym "Infected joint" ; oboInOwl:hasDbXref "MSH:D001170", "SNOMEDCT_US:372939007", "SNOMEDCT_US:396234004", "UMLS:C0003869", "UMLS:C4280547" ; oboInOwl:id "HP:0003095" ; a owl:Class ; rdfs:label "Septic arthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0003097 obo:IAO_0000115 "An abnormal shortening of the femur." ; oboInOwl:hasAlternativeId "HP:0009749" ; oboInOwl:hasDbXref "SNOMEDCT_US:93255008", "UMLS:C0345375" ; oboInOwl:hasExactSynonym "Femoral hypoplasia", "Hypoplasia of the femora", "Short femurs", "Short thighbone" ; oboInOwl:id "HP:0003097" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short femur" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0005613 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003099 obo:IAO_0000115 "Relatively increased growth of the fibula compared to that of the tibia." ; oboInOwl:hasDbXref "UMLS:C1864298" ; oboInOwl:hasExactSynonym "Overgrowth of calf bone" ; oboInOwl:id "HP:0003099" ; a owl:Class ; rdfs:label "Fibular overgrowth" ; rdfs:subClassOf obo:HP_0002991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003100 obo:IAO_0000115 "Reduced diameter of a long bone." ; oboInOwl:hasAlternativeId "HP:0003060", "HP:0003061", "HP:0003096", "HP:0005064" ; oboInOwl:hasDbXref "UMLS:C1833144" ; oboInOwl:hasExactSynonym "Gracile long bones", "Long bones slender", "Slender long bone", "Slender, gracile long tubular bones", "Thin long bones", "Thin, gracile long bones" ; oboInOwl:hasRelatedSynonym "Slender long bones", "Thin gracile long bones" ; oboInOwl:id "HP:0003100" ; a owl:Class ; rdfs:label "Slender long bone" ; rdfs:subClassOf obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003102 obo:IAO_0000115 "An abnormal increase in the carrying angle, which is the angle he long axis of the extended forearm as it lies lateral to the long axis of the arm." ; oboInOwl:hasDbXref "UMLS:C1855478" ; oboInOwl:id "HP:0003102" ; a owl:Class ; rdfs:comment "Anatomically, the carrying angle in human adults is approximately 10 degrees in men and 13 degrees in women. Increasing the carrying angle may lead to elbow instability and pain during exercise or in throwing activities of sports, may reduce function of elbow flexion, predispose to risk of elbow dislocation, and increase evidence of elbow fracture when falling on the outstretched hand and fracture of the distal humeral epiphysis." ; rdfs:label "Increased carrying angle" ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0003103 obo:IAO_0000115 "An abnormality of compact bone (also known as cortical bone), which forms the dense surface of bones." ; oboInOwl:hasDbXref "UMLS:C4021741" ; oboInOwl:hasExactSynonym "Abnormal compact bone morphology", "Abnormality of cortical bone" ; oboInOwl:id "HP:0003103" ; a owl:Class ; rdfs:label "Abnormal cortical bone morphology" ; rdfs:subClassOf obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001439 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003105 obo:IAO_0000115 "The presence of multiple protuberances (bulges, or knobs) at the ends of the long bones." ; oboInOwl:hasDbXref "UMLS:C1851418" ; oboInOwl:hasExactSynonym "Protuberances at ends of long bones" ; oboInOwl:id "HP:0003105" ; a owl:Class ; rdfs:label "Protuberances at ends of long bones" ; rdfs:subClassOf obo:HP_0011314 . obo:HP_0003106 obo:IAO_0000115 "Loss of bone mass occurring beneath the periosteum (the periosteum is the connective-tissue membrane that surrounds all bones except at the articular surfaces). This process may create a serrated and lace-like appearance in periosteal cortical bone." ; oboInOwl:hasDbXref "UMLS:C1848541" ; oboInOwl:hasExactSynonym "Subperiosteal erosions" ; oboInOwl:id "HP:0003106" ; a owl:Class ; rdfs:label "Subperiosteal bone resorption" ; rdfs:subClassOf obo:HP_0002813 . obo:HP_0003107 obo:IAO_0000115 "Any deviation from the normal concentration of cholesterol in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T01:02:00Z" ; oboInOwl:hasAlternativeId "HP:0003464" ; oboInOwl:hasDbXref "UMLS:C4025656" ; oboInOwl:hasExactSynonym "Abnormal cholesterol homeostasis", "Abnormality of cholesterol metabolism" ; oboInOwl:id "HP:0003107" ; a owl:Class ; rdfs:label "Abnormal circulating cholesterol concentration" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0008203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003108 obo:IAO_0000115 "An increased concentration of glycine in the urine." ; oboInOwl:hasAlternativeId "HP:0002931" ; oboInOwl:hasDbXref "MSH:C563009", "SNOMEDCT_US:236477004", "UMLS:C0341706", "UMLS:C0543541" ; oboInOwl:hasExactSynonym "Glycinuria", "High urine glycine levels" ; oboInOwl:id "HP:0003108" ; a owl:Class ; rdfs:comment "Normal urinary glycine total (free and combined form) excretion is around 450 mg per 24 hours." ; rdfs:label "Hyperglycinuria" ; rdfs:subClassOf obo:HP_0033099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15428 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003109 obo:IAO_0000115 "An increased excretion of phosphates in the urine." ; oboInOwl:hasAlternativeId "HP:0003266" ; oboInOwl:hasDbXref "SNOMEDCT_US:22450000", "UMLS:C0268079", "UMLS:C0948023" ; oboInOwl:hasExactSynonym "High urine phosphate levels", "Phosphaturia" ; oboInOwl:id "HP:0003109" ; a owl:Class ; rdfs:label "Hyperphosphaturia" ; rdfs:subClassOf obo:HP_0012599 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003110 obo:IAO_0000115 "An abnormality of the composition of urine or the levels of its components." ; oboInOwl:hasAlternativeId "HP:0011865", "HP:0011866" ; oboInOwl:hasDbXref "UMLS:C4025655" ; oboInOwl:hasExactSynonym "Pee issues", "Urine issues" ; oboInOwl:id "HP:0003110" ; a owl:Class ; rdfs:label "Abnormality of urine homeostasis" ; rdfs:subClassOf obo:HP_0001939, obo:HP_0011277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042592 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003111 obo:IAO_0000115 "Abnormality of the homeostasis (concentration) of a monoatomic ion." ; oboInOwl:hasAlternativeId "HP:0003253" ; oboInOwl:hasDbXref "SNOMEDCT_US:237840007", "UMLS:C1704431", "UMLS:C4025654" ; oboInOwl:hasExactSynonym "Abnormality of ion homeostasis", "Electrolyte disorders", "Electrolyte disturbance" ; oboInOwl:id "HP:0003111" ; a owl:Class ; rdfs:label "Abnormal blood ion concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24867 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003112 obo:IAO_0000115 "The presence of an abnormal decrease or increase of one or more amino acids in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4025653" ; oboInOwl:hasExactSynonym "Abnormality of serum amino acid level", "Abnormality of serum amino acid levels" ; oboInOwl:id "HP:0003112" ; a owl:Class ; rdfs:label "Abnormal circulating amino acid concentration" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33709 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003113 obo:IAO_0000115 "An abnormally decreased chloride concentration in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:10399008", "UMLS:C0085680", "UMLS:C0595901" ; oboInOwl:hasExactSynonym "Low blood chloride levels" ; oboInOwl:id "HP:0003113" ; a owl:Class ; rdfs:label "Hypochloremia" ; rdfs:subClassOf obo:HP_0011422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003114 obo:IAO_0100001 "HP:0001626" ; oboInOwl:id "HP:0003114" ; a owl:Class ; rdfs:label "obsolete Abnormal cardiological findings" ; owl:deprecated true . obo:HP_0003115 obo:IAO_0000115 "Abnormal rhythm of the heart." ; oboInOwl:hasDbXref "SNOMEDCT_US:102594003", "UMLS:C0522055" ; oboInOwl:hasExactSynonym "Abnormal ECG", "Abnormal EKG", "Abnormal electrocardiogram", "EKG abnormality" ; oboInOwl:id "HP:0003115" ; a owl:Class ; rdfs:label "Abnormal EKG" ; rdfs:subClassOf obo:HP_0030956 . obo:HP_0003116 obo:IAO_0100001 "HP:0001626" ; oboInOwl:id "HP:0003116" ; a owl:Class ; rdfs:label "Abnormal echocardiogram" ; owl:deprecated true . obo:HP_0003117 obo:IAO_0000115 "Concentration of a hormone in the blood circulation outside of normal limits." ; oboInOwl:hasDbXref "UMLS:C4025652" ; oboInOwl:hasExactSynonym "Abnormal circulating hormone level", "Abnormality of circulating hormone level" ; oboInOwl:id "HP:0003117" ; a owl:Class ; rdfs:label "Abnormal circulating hormone concentration" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003118 obo:IAO_0000115 "Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features." ; oboInOwl:hasAlternativeId "HP:0000850", "HP:0001578", "HP:0004316" ; oboInOwl:hasDbXref "MSH:D000308", "SNOMEDCT_US:237735008", "SNOMEDCT_US:275437005", "SNOMEDCT_US:47270006", "UMLS:C0001622", "UMLS:C0342443", "UMLS:C4025651" ; oboInOwl:hasExactSynonym "Cushing syndrome", "Hypercortisolism", "Increased circulating cortisol level", "Increased cortisol production" ; oboInOwl:id "HP:0003118" ; a owl:Class ; rdfs:label "Increased circulating cortisol level" ; rdfs:subClassOf obo:HP_0002717, obo:HP_0011731 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17650 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003119 obo:IAO_0000115 "Any deviation from the normal concentration of a lipid in the blood circulation." ; oboInOwl:hasAlternativeId "HP:0003611" ; oboInOwl:hasDbXref "MSH:D050171", "SNOMEDCT_US:370992007", "UMLS:C0242339", "UMLS:C4025650" ; oboInOwl:hasRelatedSynonym "Dyslipidaemia", "Dyslipidemia" ; oboInOwl:id "HP:0003119" ; a owl:Class ; rdfs:comment "According to CHEBI:18059 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." ; rdfs:label "Abnormal circulating lipid concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003121 obo:IAO_0000115 "A contracture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs." ; oboInOwl:hasAlternativeId "HP:0005631", "HP:0005839" ; oboInOwl:hasDbXref "UMLS:C1969879" ; oboInOwl:hasExactSynonym "Limb contractures" ; oboInOwl:id "HP:0003121" ; a owl:Class ; rdfs:label "Limb joint contracture" ; rdfs:subClassOf obo:HP_0001371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003124 obo:IAO_0000115 "An increased concentration of cholesterol in the blood." ; oboInOwl:hasAlternativeId "HP:0008154", "HP:0008173", "HP:0008359" ; oboInOwl:hasBroadSynonym "High cholesterol" ; oboInOwl:hasDbXref "MSH:D006937", "SNOMEDCT_US:13644009", "SNOMEDCT_US:166830008", "UMLS:C0020443", "UMLS:C0595929" ; oboInOwl:hasExactSynonym "Elevated serum cholesterol", "Elevated total cholesterol", "Increased total cholesterol" ; oboInOwl:id "HP:0003124" ; a owl:Class ; rdfs:label "Hypercholesterolemia" ; rdfs:subClassOf obo:HP_0003107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16113 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003125 obo:IAO_0000115 "Reduced activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X." ; oboInOwl:hasAlternativeId "HP:0008349", "HP:0008355" ; oboInOwl:hasDbXref "MSH:D006467", "SNOMEDCT_US:234440005", "UMLS:C3494187", "UMLS:C4025649" ; oboInOwl:hasRelatedSynonym "Factor VIII deficiency" ; oboInOwl:id "HP:0003125" ; a owl:Class ; rdfs:label "Reduced factor VIII activity" ; rdfs:subClassOf obo:HP_0030976 . obo:HP_0003126 obo:IAO_0000115 "Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD)." ; oboInOwl:hasDbXref "UMLS:C1839606" ; oboInOwl:hasExactSynonym "Tubular proteinuria" ; oboInOwl:id "HP:0003126" ; a owl:Class ; rdfs:label "Low-molecular-weight proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_0003127 obo:IAO_0000115 "An abnormally decreased calcium concentration in the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:86353007", "UMLS:C0020599" ; oboInOwl:hasExactSynonym "Low urine calcium levels" ; oboInOwl:id "HP:0003127" ; a owl:Class ; rdfs:label "Hypocalciuria" ; rdfs:subClassOf obo:HP_0011280 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003128 obo:IAO_0000115 "An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids." ; oboInOwl:hasAlternativeId "HP:0003255", "HP:0005960" ; oboInOwl:hasDbXref "MSH:D000140", "SNOMEDCT_US:190882007", "SNOMEDCT_US:91273001", "UMLS:C0001125", "UMLS:C0347959" ; oboInOwl:hasExactSynonym "Hyperlacticacidemia", "Increased lactate in body", "Lactic acidemia", "Lacticacidemia", "Lacticacidosis" ; oboInOwl:id "HP:0003128" ; a owl:Class ; rdfs:comment "Note that the term acidemia is used to describe the state of low pH in the blood, whereas acidosis is used to describe the processes that lead to acidemia. In medical jargon, however, the two terms are used interchangeably." ; rdfs:label "Lactic acidosis" ; rdfs:subClassOf obo:HP_0001941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28358 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003130 obo:IAO_0000115 "An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense." ; oboInOwl:hasAlternativeId "HP:0003408" ; oboInOwl:hasDbXref "UMLS:C4025648" ; oboInOwl:id "HP:0003130" ; a owl:Class ; rdfs:comment "This finding may be observed upon biopsy of the sural nerve. Myelination, i.e., the presence of a segmented lipid-rich sheath (myelin), enables faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system (GO:0022011)." ; rdfs:label "Abnormal peripheral myelination" ; rdfs:subClassOf obo:HP_0000759, obo:HP_0012447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0022011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003131 obo:IAO_0000115 "An increased concentration of cystine in the urine." ; oboInOwl:hasDbXref "MSH:D003555", "SNOMEDCT_US:85020001", "UMLS:C0010691" ; oboInOwl:hasExactSynonym "High urine cystine levels" ; oboInOwl:id "HP:0003131" ; a owl:Class ; rdfs:comment "Cystine is a sulfur-containing amino acid." ; rdfs:label "Cystinuria" ; rdfs:subClassOf obo:HP_0033095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003133 obo:IAO_0000115 "An abnormality of the spinocerebellar tracts, a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. The spinocerebellar tract convey information to the cerebellum about limb and joint position (proprioception). They comprise the ventral spinocerebellar tract, the anterior spinocerebellar tract, and the posterior spinocerebellar tract." ; oboInOwl:hasDbXref "UMLS:C4025647" ; oboInOwl:id "HP:0003133" ; a owl:Class ; rdfs:label "Abnormality of the spinocerebellar tracts" ; rdfs:subClassOf obo:HP_0002143 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003134 obo:IAO_0000115 "An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS)." ; oboInOwl:hasAlternativeId "HP:0006832", "HP:0007186" ; oboInOwl:hasDbXref "UMLS:C4020690" ; oboInOwl:hasExactSynonym "Sensory and motor nerve conduction abnormalities" ; oboInOwl:hasRelatedSynonym "Abnormal peripheral nerve transmission" ; oboInOwl:id "HP:0003134" ; a owl:Class ; rdfs:comment "A nerve conduction study (NCS) is commonly conducted together with electromyography in order to evaluate muscle disorders. For the NCS, dermal electrodes are placed at intervals over the nerve to be examined, and a low-intensity current is introducted to generate action potentials. The velocity of the action potential is related to the diameter of the nerve fiber and the presence of a myelin sheath. Diseases of the myelin sheath characteristically reduce the nerve conduction velocity (NCV). The amplitude of the response is also measured." ; rdfs:label "Abnormality of peripheral nerve conduction" ; rdfs:subClassOf obo:HP_0030177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000111 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019226 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003137 obo:IAO_0000115 "Level of proline in the urine anove the upper limit of normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:53124003", "UMLS:C0268534" ; oboInOwl:hasExactSynonym "Proline high in urine" ; oboInOwl:id "HP:0003137" ; a owl:Class ; rdfs:comment "Normal urinary proline total (free and combined form) excretion is around 40 mg per 24 hours." ; rdfs:label "Prolinuria" ; rdfs:subClassOf obo:HP_0033100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26271 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003138 obo:IAO_0000115 "An increased amount of nitrogen in the form of urea in the blood." ; oboInOwl:hasDbXref "UMLS:C0151539" ; oboInOwl:hasExactSynonym "Increased BUN", "Increased blood urea nitrogen" ; oboInOwl:id "HP:0003138" ; a owl:Class ; rdfs:label "Increased blood urea nitrogen" ; rdfs:subClassOf obo:HP_0002157, obo:HP_0031970 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16199 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003139 obo:IAO_0000115 "A reduction in the circulating levels of all the major classes of immunoglobulin. is characterized by profound decreases in all classes of immunoglobulin with an absence of circulating B lymphocytes." ; oboInOwl:hasDbXref "UMLS:C1328587" ; oboInOwl:hasExactSynonym "Panhypogammaglobulinaemia", "Panypogammaglobulinemia" ; oboInOwl:id "HP:0003139" ; a owl:Class ; rdfs:label "Panhypogammaglobulinemia" ; rdfs:subClassOf obo:HP_0004313 . obo:HP_0003140 oboInOwl:hasDbXref "UMLS:C4025646" ; oboInOwl:id "HP:0003140" ; a owl:Class ; rdfs:label "T-wave inversion in the right precordial leads" ; rdfs:subClassOf obo:HP_0010872 . obo:HP_0003141 obo:IAO_0000115 "An elevated concentration of low-density lipoprotein cholesterol in the blood." ; oboInOwl:hasAlternativeId "HP:0008343" ; oboInOwl:hasDbXref "MSH:D006938", "SNOMEDCT_US:190773008", "SNOMEDCT_US:398036000", "UMLS:C0020445", "UMLS:C0549399" ; oboInOwl:hasExactSynonym "Hyperbetalipoproteinemia", "Increased LDL cholesterol", "Increased LDLc concentration", "Increased beta-lipoproteins", "Increased circulating LDL level", "Increased circulating low-density lipoprotein cholesterol", "Increased circulating low-density lipoprotein levels", "Increased plasma LDL levels" ; oboInOwl:id "HP:0003141" ; a owl:Class ; rdfs:label "Increased LDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010980, obo:HP_0031886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47774 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003142 oboInOwl:hasDbXref "UMLS:C4025645" ; oboInOwl:id "HP:0003142" ; a owl:Class ; rdfs:label "Excessive purine production" ; rdfs:subClassOf obo:HP_0012337 . obo:HP_0003144 obo:IAO_0000115 "A increased concentration of serotonin in the blood." ; oboInOwl:hasDbXref "UMLS:C0877243" ; oboInOwl:hasExactSynonym "Increased serum serotonin" ; oboInOwl:id "HP:0003144" ; a owl:Class ; rdfs:label "Increased serum serotonin" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28790 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003145 obo:IAO_0000115 "Decreased concentration of adenosylcobalamin. Adenosylcobalamin is one of the active forms of vitamin B12." ; oboInOwl:hasDbXref "UMLS:C1848556" ; oboInOwl:hasExactSynonym "Decreased ADOCBL" ; oboInOwl:id "HP:0003145" ; a owl:Class ; rdfs:label "Decreased adenosylcobalamin" ; rdfs:subClassOf obo:HP_0040126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_18408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003146 obo:IAO_0000115 "An decreased concentration of cholesterol in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:61336008", "UMLS:C0151718" ; oboInOwl:hasExactSynonym "Decreased circulating cholesterol level" ; oboInOwl:id "HP:0003146" ; a owl:Class ; rdfs:label "Hypocholesterolemia" ; rdfs:subClassOf obo:HP_0003107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16113 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003148 oboInOwl:hasDbXref "UMLS:C1839866" ; oboInOwl:hasExactSynonym "Acid phosphatase elevated", "Elevated serum acid phosphatase" ; oboInOwl:id "HP:0003148" ; a owl:Class ; rdfs:comment "Acid phosphatase can free attached phosphate groups from other molecules. It is a lysosomal enzyme." ; rdfs:label "Elevated serum acid phosphatase" ; rdfs:subClassOf obo:HP_0004356 . obo:HP_0003149 obo:IAO_0000115 "An abnormally high level of uric acid in the urine." ; oboInOwl:hasAlternativeId "HP:0012611" ; oboInOwl:hasDbXref "UMLS:C0948643" ; oboInOwl:hasExactSynonym "High urine uric acid level", "Increased urinary urate" ; oboInOwl:id "HP:0003149" ; a owl:Class ; rdfs:comment "Xanthine oxidase oxidizes oxypurines such as xanthine and hypoxanthine to uric acid. Uric acid is the final oxidation product of purine catabolism." ; rdfs:label "Hyperuricosuria" ; rdfs:subClassOf obo:HP_0012610 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003150 obo:IAO_0000115 "The concentration of glutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; oboInOwl:hasAlternativeId "HP:0003490" ; oboInOwl:hasDbXref "SNOMEDCT_US:28987007", "UMLS:C0268594" ; oboInOwl:hasExactSynonym "Glutarate aciduria", "Glutaricaciduria", "Increased glutarate level in urine" ; oboInOwl:id "HP:0003150" ; a owl:Class ; rdfs:label "Glutaric aciduria" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17859 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003152 obo:IAO_0100001 "HP:0031415" ; a owl:Class ; rdfs:label "obsolete Increased serum 1,25-dihydroxyvitamin D3" ; owl:deprecated true . obo:HP_0003153 obo:IAO_0000115 "An elevated urinary concentration of cystathionine." ; oboInOwl:hasDbXref "SNOMEDCT_US:13003007", "UMLS:C0220993" ; oboInOwl:hasExactSynonym "High urine cystathionine levels" ; oboInOwl:id "HP:0003153" ; a owl:Class ; rdfs:comment "Cystathionine can be directly interconverted to cysteine. Normal cystathione urinary values are under 150 micromole per gram creatinine." ; rdfs:label "Cystathioninuria" ; rdfs:subClassOf obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17755 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003154 obo:IAO_0000115 "An abnormal increased in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood." ; oboInOwl:hasDbXref "UMLS:C4021740" ; oboInOwl:hasExactSynonym "High blood corticotropin levels", "Increased circulating ACTH level", "Increased plasma ACTH" ; oboInOwl:id "HP:0003154" ; a owl:Class ; rdfs:label "Increased circulating ACTH level" ; rdfs:subClassOf obo:HP_0011043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003155 obo:IAO_0000115 "Abnormally increased serum levels of alkaline phosphatase activity." ; oboInOwl:hasAlternativeId "HP:0002911", "HP:0003636", "HP:0008296" ; oboInOwl:hasDbXref "UMLS:C0750857" ; oboInOwl:hasExactSynonym "Elevated ALP", "Elevated alkaline phosphatase", "Greatly elevated alkaline phosphatase", "High serum alkaline phosphatase", "Hyperphosphatasemia", "Hyperphosphatasia", "Increased alkaline phosphatase", "Increased serum alkaline phosphatase" ; oboInOwl:id "HP:0003155" ; a owl:Class ; rdfs:label "Elevated circulating alkaline phosphatase concentration" ; rdfs:subClassOf obo:HP_0004379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003158 obo:IAO_0000115 "An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:76023003", "UMLS:C0232831" ; oboInOwl:hasExactSynonym "Reduced urinary osmolality" ; oboInOwl:id "HP:0003158" ; a owl:Class ; rdfs:comment "Hyposthenuria may occur with impaired renal concentrating power or upon abnormally low hormonal stimulation, as in diabetes insipidus." ; rdfs:label "Hyposthenuria" ; rdfs:subClassOf obo:HP_0033358 . obo:HP_0003159 obo:IAO_0000115 "Increased excretion of oxalates in the urine." ; oboInOwl:hasDbXref "MSH:D006959", "SNOMEDCT_US:367621000119107", "UMLS:C0020500" ; oboInOwl:hasExactSynonym "High urine oxalate levels", "Increased level of oxalate in urine" ; oboInOwl:id "HP:0003159" ; a owl:Class ; rdfs:label "Hyperoxaluria" ; rdfs:subClassOf obo:HP_0001992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_132952 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003160 obo:IAO_0000115 "Glycosylated transferrin concentrations can be measured in serum as a marker of N-linked glycosylation fidelity. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II. These terms are retained for historical reasons but for new annotations the precise glycosylation defect should be recorded." ; oboInOwl:hasDbXref "UMLS:C2749688" ; oboInOwl:hasExactSynonym "Abnormal isoelectric focusing of transferrin", "Abnormal transferrin isoelectric focusing" ; oboInOwl:id "HP:0003160" ; a owl:Class ; rdfs:comment "Human serum transferrin has two N-glycosylation sites, which are normally both fully occupied by disialylated biantennary glycans to generate tetrasialotransferrin." ; rdfs:label "Abnormal isoelectric focusing of serum transferrin" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0003161 obo:IAO_0000115 "Increased relative concentration of 4-hydroxyphenylpyruvic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C1848678" ; oboInOwl:hasExactSynonym "Hydroxyphenylpyruvic aciduria" ; oboInOwl:id "HP:0003161" ; a owl:Class ; rdfs:label "4-Hydroxyphenylpyruvic aciduria" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15999 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003162 oboInOwl:hasDbXref "MSH:D007003", "SNOMEDCT_US:6974005", "UMLS:C0271708" ; oboInOwl:hasExactSynonym "Low blood sugar when fasting" ; oboInOwl:id "HP:0003162" ; a owl:Class ; rdfs:label "Fasting hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0003163 obo:IAO_0000115 "An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine." ; oboInOwl:hasDbXref "UMLS:C1848702" ; oboInOwl:hasExactSynonym "Elevated urinary delta-aminolevulinic acid" ; oboInOwl:id "HP:0003163" ; a owl:Class ; rdfs:comment "Delta-aminolevulinic acid synthesis is a rate-controlling step in heme synthesis." ; rdfs:label "Elevated urinary delta-aminolevulinic acid" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17549 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003164 oboInOwl:hasDbXref "UMLS:C4025644" ; oboInOwl:hasExactSynonym "Hypothalamic GNRH deficiency" ; oboInOwl:id "HP:0003164" ; a owl:Class ; rdfs:label "Hypothalamic gonadotropin-releasing hormone deficiency" ; rdfs:subClassOf obo:HP_0012285, obo:HP_0500012 . obo:HP_0003165 obo:IAO_0000115 "An abnormal increased concentration of parathyroid hormone." ; oboInOwl:hasDbXref "UMLS:C0857973" ; oboInOwl:hasExactSynonym "Elevated circulating PTH level", "Elevated serum parathyroid hormone", "Elevated serum parathyroid hormone level", "Elevated serum pth", "Increased serum parathyroid hormone" ; oboInOwl:id "HP:0003165" ; a owl:Class ; rdfs:label "Elevated circulating parathyroid hormone level" ; rdfs:subClassOf obo:HP_0100530 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000013429 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003166 obo:IAO_0000115 "Increased concentration of taurine in the urine." ; oboInOwl:hasDbXref "UMLS:C3806447" ; oboInOwl:hasExactSynonym "Increased urinary taurine" ; oboInOwl:id "HP:0003166" ; a owl:Class ; rdfs:label "Increased urinary taurine" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003167 obo:IAO_0000115 "An increased concentration of carnosine in the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:410051001", "UMLS:C3495558" ; oboInOwl:hasExactSynonym "High urine carnosine levels" ; oboInOwl:id "HP:0003167" ; a owl:Class ; rdfs:comment "Carnosine is the N-(beta-alanyl) derivative of L-histidine." ; rdfs:label "Carnosinuria" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003168 obo:IAO_0000115 "An increased level of a dibasic amino acid in the urine. Dibasic amino acids are usually refered to simply as basic aminoacids because they contain basic side chains at neutral pH. These are arginine (Arg), lysine (Lys), and histidine (His)." ; oboInOwl:hasDbXref "UMLS:C4025643" ; oboInOwl:id "HP:0003168" ; a owl:Class ; rdfs:label "Dibasicaminoaciduria" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0003170 obo:IAO_0000115 "An abnormality of the acetabulum, i.e., the Acetabular part of hip bone, which together with the head of the femur forms the hip joint." ; oboInOwl:hasDbXref "UMLS:C4021739" ; oboInOwl:hasExactSynonym "Abnormality of the acetabulum", "Abnormality of the hipbone socket", "Acetabular abnormality" ; oboInOwl:id "HP:0003170" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal acetabulum morphology" ; rdfs:subClassOf obo:HP_0001384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001269 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003172 obo:IAO_0000115 "An anomaly of the the pubic bone, i.e., of the ventral and anterior of the three principal components (pubis, ilium, ischium) of the hip bone." ; oboInOwl:hasDbXref "UMLS:C4021738" ; oboInOwl:hasExactSynonym "Abnormality of the pubic bone", "Abnormality of the pubic bones", "Abnormality of the pubis" ; oboInOwl:id "HP:0003172" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal pubic bone morphology" ; rdfs:subClassOf obo:HP_0003272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003173 obo:IAO_0000115 "Underdevelopment of the pubis, which together with the ilium and the ischium, is one of the three bones that make up the hip bone." ; oboInOwl:hasDbXref "UMLS:C1865030" ; oboInOwl:hasExactSynonym "Hypoplastic pubic bones", "Hypoplastic pubis" ; oboInOwl:id "HP:0003173" ; a owl:Class ; rdfs:label "Hypoplastic pubic bone" ; rdfs:subClassOf obo:HP_0009104 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003174 obo:IAO_0000115 "An anomaly of the ischium, which forms the lower and back part of the hip bone." ; oboInOwl:hasDbXref "SNOMEDCT_US:93008005", "UMLS:C0685661" ; oboInOwl:hasExactSynonym "Abnormality of the ischial bones", "Abnormality of the ischium", "Anomaly of the ischium" ; oboInOwl:id "HP:0003174" ; a owl:Class ; rdfs:comment "The ischium, together with the ilium and the pubis, forms the hip bone (os coxae)." ; rdfs:label "Abnormal ischium morphology" ; rdfs:subClassOf obo:HP_0003272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001274 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003175 obo:IAO_0000115 "Underdevelopment of the ischium, which forms the lower and back part of the hip bone." ; oboInOwl:hasDbXref "UMLS:C1859447" ; oboInOwl:hasExactSynonym "Hypoplastic ischial bones", "Hypoplastic ischii", "Hypoplastic ischium" ; oboInOwl:id "HP:0003175" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic ischia" ; rdfs:subClassOf obo:HP_0003174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001274 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003177 obo:IAO_0000115 "A shift from the normally round (convex) appearance of the iliac wing towards a square-like appearance." ; oboInOwl:hasDbXref "UMLS:C1838186" ; oboInOwl:hasExactSynonym "Square iliac bones", "Squaring of iliac bones" ; oboInOwl:id "HP:0003177" ; a owl:Class ; rdfs:label "Squared iliac bones" ; rdfs:subClassOf obo:HP_0002867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000413 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003179 obo:IAO_0000115 "Intrapelvic bulging of the medial acetabular wall." ; oboInOwl:hasDbXref "SNOMEDCT_US:59606006", "UMLS:C0409495" ; oboInOwl:hasExactSynonym "Abnormally indented hip sockets", "Protrusio acetabulae" ; oboInOwl:id "HP:0003179" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Protrusion of the acetabulum, which is the socket that together with the head of the femur forms the hip joint. The protrusion is the result of increased depth of the socket and results in medial displacement of the femoral head." ; rdfs:label "Protrusio acetabuli" ; rdfs:subClassOf obo:HP_0003170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001269 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003180 obo:IAO_0000115 "Flattening of the superior part of the acetabulum, which is a cup-shaped cavity at the base of the hipbone into which the ball-shaped head of the femur fits. The acetabular roof thereby appears horizontal rather than arched, as it normally does." ; oboInOwl:hasAlternativeId "HP:0003171", "HP:0008832", "HP:0008834" ; oboInOwl:hasDbXref "UMLS:C1837485" ; oboInOwl:hasExactSynonym "Acetabular angle flat", "Flat acetabular roofs", "Flattened acetabular roof", "Horizontal acetabulae", "Horizontal acetabular roof", "Horizontal acetabular roofs" ; oboInOwl:id "HP:0003180" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Flat acetabular roof" ; rdfs:subClassOf obo:HP_0003170 . obo:HP_0003182 oboInOwl:hasDbXref "UMLS:C1854910", "UMLS:C1860796" ; oboInOwl:hasExactSynonym "Shallow acetabula", "Shallow acetabulae", "Shallow acetabular fossa", "Shallow acetabulum" ; oboInOwl:id "HP:0003182" ; a owl:Class ; rdfs:label "Shallow acetabular fossae" ; rdfs:subClassOf obo:HP_0003170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001472 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003183 obo:IAO_0000115 "Abnormally increased width of the pubic symphysis is the midline cartilaginous joint uniting the superior rami of the left and right pubic bones." ; oboInOwl:hasDbXref "UMLS:C1857190" ; oboInOwl:hasExactSynonym "Wide symphysis of pubis" ; oboInOwl:id "HP:0003183" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Wide pubic symphysis" ; rdfs:subClassOf obo:HP_0003172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003699 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003184 obo:IAO_0000115 "Reduced ability to move the femur outward to the side." ; oboInOwl:hasDbXref "UMLS:C1836589" ; oboInOwl:hasExactSynonym "Limited hip abduction" ; oboInOwl:id "HP:0003184" ; a owl:Class ; rdfs:label "Decreased hip abduction" ; rdfs:subClassOf obo:HP_0008800 . obo:HP_0003185 obo:IAO_0000115 "The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a reduction in the height of the notch." ; oboInOwl:hasAlternativeId "HP:0008815" ; oboInOwl:hasDbXref "UMLS:C1866689" ; oboInOwl:hasExactSynonym "Short sacroiliac notch", "Shortened sacroiliac notches", "Small sacroiliac notch" ; oboInOwl:id "HP:0003185" ; a owl:Class ; rdfs:label "Short greater sciatic notch" ; rdfs:subClassOf obo:HP_0010456 . obo:HP_0003186 obo:IAO_0000115 "The presence of nipples that instead of pointing outward are retracted inwards." ; oboInOwl:hasDbXref "SNOMEDCT_US:82231009", "UMLS:C0269269" ; oboInOwl:hasExactSynonym "Invaginated nipples", "Inverted nipples" ; oboInOwl:id "HP:0003186" ; a owl:Class ; rdfs:label "Inverted nipples" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000625 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003187 obo:IAO_0000115 "Underdevelopment of the breast." ; oboInOwl:hasAlternativeId "HP:0000784" ; oboInOwl:hasDbXref "SNOMEDCT_US:8915006", "UMLS:C0266013" ; oboInOwl:hasExactSynonym "Underdeveloped breasts" ; oboInOwl:id "HP:0003187" ; a owl:Class ; rdfs:label "Breast hypoplasia" ; rdfs:subClassOf obo:HP_0010311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003189 obo:IAO_0000115 "Distance from nasion to subnasale more than two standard deviations above the mean, or alternatively, an apparently increased length from the nasal root to the nasal base." ; oboInOwl:hasAlternativeId "HP:0005283", "HP:0200142" ; oboInOwl:hasDbXref "UMLS:C1839798" ; oboInOwl:hasExactSynonym "Elongated nose", "Increased height of nose", "Increased length of nose", "Increased nasal height", "Increased nasal length", "Long nose", "Nasal elongation" ; oboInOwl:id "HP:0003189" ; a owl:Class ; rdfs:label "Long nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003191 obo:IAO_0000115 "The presence of a notch in the margin of the ala nasi." ; oboInOwl:hasAlternativeId "HP:0004412" ; oboInOwl:hasDbXref "UMLS:C1844537" ; oboInOwl:hasExactSynonym "Ala nasi, cleft", "Alar clefts", "Cleft nasal alae", "Cleft nostril", "Notched nasal alae" ; oboInOwl:hasRelatedSynonym "Nostril coloboma" ; oboInOwl:id "HP:0003191" ; a owl:Class ; rdfs:comment "The alae nasi are the lateral portions of the nose or the wings of the nostrils, which partly encircle the nostrils (nares). They are usually about the width of the columella, but vary greatly depending on the shape of the nostril. Note that individuals may be described as having a cleft ala nasi, but have a severely Underdeveloped ala nasi. In an underdeveloped ala the continuity of the tissue encircling the nostril is undisturbed while in a cleft it is disrupted. The term coloboma has been replaced because a coloboma is a remnant of a physiologically occurring discontinuity of tissue; the alae nasi do not have such a discontinuity." ; rdfs:label "Cleft ala nasi" ; rdfs:subClassOf obo:HP_0000429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001495 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003193 obo:IAO_0000115 "It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea." ; oboInOwl:hasDbXref "MSH:D065631", "SNOMEDCT_US:61582004", "UMLS:C0847614", "UMLS:C2607914" ; oboInOwl:hasExactSynonym "Hay fever", "Hayfever" ; oboInOwl:hasRelatedSynonym "Nasal allergies" ; oboInOwl:id "HP:0003193" ; a owl:Class ; rdfs:label "Allergic rhinitis" ; rdfs:subClassOf obo:HP_0012384, obo:HP_0012393 . obo:HP_0003194 obo:IAO_0000115 "Decreased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose." ; oboInOwl:hasDbXref "UMLS:C1854689" ; oboInOwl:hasExactSynonym "Decreased length of bridge of nose", "Decreased length of nasal bridge", "Short bridge of nose", "Short nasal bridge" ; oboInOwl:id "HP:0003194" ; a owl:Class ; rdfs:label "Short nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003196 obo:IAO_0000115 "Distance from nasion to subnasale more than two standard deviations below the mean, or alternatively, an apparently decreased length from the nasal root to the nasal tip." ; oboInOwl:hasAlternativeId "HP:0000440", "HP:0000449", "HP:0000450", "HP:0003192", "HP:0003195", "HP:0005270", "HP:0200092" ; oboInOwl:hasDbXref "SNOMEDCT_US:249310005", "UMLS:C0426414", "UMLS:C1854114" ; oboInOwl:hasExactSynonym "Decreased length of nose", "Hypoplastic nose", "Nasal hypoplasia", "Short nose", "Shortened nose" ; oboInOwl:hasRelatedSynonym "Small nose" ; oboInOwl:id "HP:0003196" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note: a small nose has both decreased height and a decreased width. These should be coded separately." ; rdfs:label "Short nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003198 obo:IAO_0000115 "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." ; oboInOwl:hasAlternativeId "HP:0003569", "HP:0003705", "HP:0003742", "HP:0003802" ; oboInOwl:hasDbXref "MSH:D009135", "SNOMEDCT_US:129565002", "UMLS:C0026848" ; oboInOwl:hasExactSynonym "Muscle tissue disease", "Myopathic changes" ; oboInOwl:id "HP:0003198" ; a owl:Class ; rdfs:comment "The diagnosis of myopathy is often confirmed on the basis of myopathic changes in muscle biopsy." ; rdfs:label "Myopathy" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003199 oboInOwl:hasAlternativeId "HP:0003732" ; oboInOwl:hasDbXref "UMLS:C1837108" ; oboInOwl:hasExactSynonym "Decreased muscle mass" ; oboInOwl:id "HP:0003199" ; a owl:Class ; rdfs:label "Decreased muscle mass" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003200 obo:IAO_0000115 "An abnormal appearance of muscle fibers observed on muscle biopsy. Ragged red fibers can be visualized with Gomori trichrome staining as irregular and intensely red subsarcolemmal zones, whereas the normal myofibrils are green. The margins of affect fibers appear red and ragged. The ragged-red is due to the accumulation of abnormal mitochondria below the plasma membrane of the muscle fiber, leading to the appearance of a red rim and speckled sarcoplasm." ; oboInOwl:hasAlternativeId "HP:0009076" ; oboInOwl:hasDbXref "UMLS:C3275417" ; oboInOwl:hasExactSynonym "Mitochondrial proliferation in muscle tissue", "Ragged red muscle fibers", "Ragged red muscle fibres", "Ragged-red fibers", "Ragged-red fibres", "Ragged-red muscle fibres" ; oboInOwl:id "HP:0003200" ; a owl:Class ; rdfs:comment "This finding is demonstrated by muscle biopsy. Note that additionally, muscle fibers with mitochondrial proliferation stain darkly for succinic dehydrogenase (SDH)." ; rdfs:label "Ragged-red muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003201 obo:IAO_0000115 "Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream." ; oboInOwl:hasDbXref "MSH:D012206", "SNOMEDCT_US:240131006", "SNOMEDCT_US:89010004", "UMLS:C0035410" ; oboInOwl:hasExactSynonym "Breakdown of skeletal muscle" ; oboInOwl:id "HP:0003201" ; a owl:Class ; rdfs:label "Rhabdomyolysis" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0003202 obo:IAO_0000115 "The presence of skeletal muscular atrophy (which is also known as amyotrophy)." ; oboInOwl:hasAlternativeId "HP:0001299", "HP:0003545", "HP:0003671", "HP:0003702", "HP:0003746", "HP:0006995", "HP:0007171", "HP:0007356", "HP:0009010", "HP:0009048", "HP:0100868" ; oboInOwl:hasDbXref "MSH:D009133", "SNOMEDCT_US:74035001", "UMLS:C0234958", "UMLS:C0270948", "UMLS:C0541794", "UMLS:C1843479" ; oboInOwl:hasExactSynonym "Amyotrophy", "Amyotrophy involving the extremities", "Muscle atrophy", "Muscle atrophy, neurogenic", "Muscle degeneration", "Muscle hypotrophy", "Muscle wasting", "Muscular atrophy", "Neurogenic muscle atrophy", "Neurogenic muscle atrophy, especially in the lower limbs", "Neurogenic muscular atrophy" ; oboInOwl:id "HP:0003202" ; a owl:Class ; rdfs:label "Skeletal muscle atrophy" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0030236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003203 obo:IAO_0000115 "In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria." ; oboInOwl:hasDbXref "UMLS:C4280805" ; oboInOwl:hasExactSynonym "Negative NBT reduction test", "Negative nitroblue tetrazolium reduction test" ; oboInOwl:id "HP:0003203" ; a owl:Class ; rdfs:comment "The NBT test measures the ability of neutrophils to convert nitroblue tetrazolium (NBT), to a deep blue color. This test can be abnormal in chronic granulomatous disease." ; rdfs:label "Impaired oxidative burst" ; rdfs:subClassOf obo:HP_0011993 . obo:HP_0003204 obo:IAO_0000115 "The intracellular accumulation of autofluorescent storage material." ; oboInOwl:hasDbXref "UMLS:C4025642" ; oboInOwl:id "HP:0003204" ; a owl:Class ; rdfs:comment "Accumulation of intracellular autofluorescent material or aging pigment has been characterized as a normal aging event. Lipofuscin (from the Greek word for fat and the Latin word for dark), refers to intracellular autofluorescent material that accumulates in aging cells with a excitation wavelength between 320 and 480 nm and an emission wavelength between 460 and 630 nm. Lpofuscin consists of a mixture of oxidized proteins and lipids, carbohydrates and trace amount of metals. Ceroid iss a lipofuscin-like lipopigment that arises from pathological conditions such as disease, malnutrition, and cell stress. Subunit c of mitochondrial ATP synthase makes up approximately 40% of this lipopigment/ceroid accumulation." ; rdfs:label "Intracellular accumulation of autofluorescent lipopigment storage material" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0003205 obo:IAO_0000115 "An intracellular accumulation of autofluorescent lipopigment storage material in a curved pattern." ; oboInOwl:hasDbXref "UMLS:C1836852" ; oboInOwl:hasExactSynonym "Curvilinear profiles ultrastructurally", "Curvilinear profiles ultrastructurally in cells", "Intracellular curvilinear profiles on ultrastructural analysis" ; oboInOwl:id "HP:0003205" ; a owl:Class ; rdfs:label "Curvilinear intracellular accumulation of autofluorescent lipopigment storage material" ; rdfs:subClassOf obo:HP_0003204 . obo:HP_0003206 oboInOwl:hasDbXref "UMLS:C1844394" ; oboInOwl:id "HP:0003206" ; a owl:Class ; rdfs:label "Decreased activity of NADPH oxidase" ; rdfs:subClassOf obo:HP_0004358 . obo:HP_0003207 obo:IAO_0000115 "Pathological deposition of calcium salts in one or more arteries." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:05:00Z" ; oboInOwl:hasAlternativeId "HP:0012455" ; oboInOwl:hasDbXref "UMLS:C1168153" ; oboInOwl:id "HP:0003207" ; a owl:Class ; rdfs:comment "Most individuals aged over 60 years have progressively enlarging deposits of calcium mineral in their major arteries. This vascular calcification reduces aortic and arterial elastance, which impairs cardiovascular hemodynamics, resulting in substantial morbidity and mortality in the form of hypertension, aortic stenosis, cardiac hypertrophy, myocardial and lower-limb ischemia, congestive heart failure, and compromised structural integrity.The severity and extent of mineralization reflect atherosclerotic plaque burden and strongly and independently predict cardiovascular morbidity and mortality. (From PMID:18519861)." ; rdfs:label "Arterial calcification" ; rdfs:subClassOf obo:HP_0004934, obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003208 obo:IAO_0000115 "An intracellular accumulation of autofluorescent lipopigment storage material in a trabecular or fingerprint-like pattern." ; oboInOwl:hasDbXref "UMLS:C1836851" ; oboInOwl:hasExactSynonym "Fingerprint profiles ultrastructurally", "Fingerprint profiles ultrastructurally in cells" ; oboInOwl:id "HP:0003208" ; a owl:Class ; rdfs:label "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material" ; rdfs:subClassOf obo:HP_0003204 . obo:HP_0003209 obo:IAO_0000115 "A decreased rate of pyruvate carboxylase activity." ; oboInOwl:hasDbXref "UMLS:C4025641" ; oboInOwl:id "HP:0003209" ; a owl:Class ; rdfs:comment "Pyruvate carboxylase (EC 6.4.1.1) is a nuclear-encoded mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a precursor for the citric acid cycle." ; rdfs:label "Decreased pyruvate carboxylase activity" ; rdfs:subClassOf obo:HP_0000816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0004736 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003210 obo:IAO_0000115 "An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity." ; oboInOwl:hasDbXref "UMLS:C1848579" ; oboInOwl:hasExactSynonym "Decreased methylmalonyl CoA mutase activity" ; oboInOwl:id "HP:0003210" ; a owl:Class ; rdfs:comment "The product of the enzyme, succinyl-CoA, is a key molecule of the TCA (Krebs) cycle. The substrate of the enzyme, methylmalonyl-CoA, is primarily derived from propionyl-CoA, a substance formed from the catabolism of isoleucine, valine, threonine, methionine, thymine, uracil, cholesterol, or odd-chain fatty acids." ; rdfs:label "Decreased methylmalonyl-CoA mutase activity" ; rdfs:subClassOf obo:HP_0000816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0004494 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003212 obo:IAO_0000115 "An abnormally increased overall level of immunoglobulin E in blood." ; oboInOwl:hasAlternativeId "HP:0005382", "HP:0005418", "HP:0005433" ; oboInOwl:hasDbXref "UMLS:C0236175" ; oboInOwl:hasExactSynonym "Elevated immunoglobulin E", "Elevated serum IgE", "High immunoglobulin E" ; oboInOwl:id "HP:0003212" ; a owl:Class ; rdfs:label "Increased circulating IgE level" ; rdfs:subClassOf obo:HP_0010702, obo:HP_0410241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071743 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003213 oboInOwl:hasDbXref "UMLS:C4025640" ; oboInOwl:id "HP:0003213" ; a owl:Class ; rdfs:label "Deficient excision of UV-induced pyrimidine dimers in DNA" ; rdfs:subClassOf obo:HP_0003254 . obo:HP_0003214 oboInOwl:hasDbXref "UMLS:C4025639" ; oboInOwl:id "HP:0003214" ; a owl:Class ; rdfs:label "Prolonged G2 phase of cell cycle" ; rdfs:subClassOf obo:HP_0011018 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000498 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0051319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003215 obo:IAO_0000115 "An increased concentration of dicarboxylic acid in the urine." ; oboInOwl:hasAlternativeId "HP:0033455" ; oboInOwl:hasDbXref "UMLS:C1856432" ; oboInOwl:hasExactSynonym "Elevated urinary dicarboxylic acid level" ; oboInOwl:id "HP:0003215" ; a owl:Class ; rdfs:comment "A dicarboxylic acid is an oxoacid containing two carboxy groups. Dicarboxylic aciduria occurs during increased mobilization or inhibited beta-oxidation of fatty acids, where a number of 3-hydroxydicarboxylic acids are excreted in the urine." ; rdfs:label "Dicarboxylic aciduria" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_35692 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003216 obo:IAO_0000115 "A diffuse form of amyloidosis." ; oboInOwl:hasDbXref "UMLS:C1862968" ; oboInOwl:hasExactSynonym "Generalised amyloid deposition" ; oboInOwl:id "HP:0003216" ; a owl:Class ; rdfs:comment "According to MeSH (D000682), Amyloid is fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of amyloid plaques are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease." ; rdfs:label "Generalized amyloid deposition" ; rdfs:subClassOf obo:HP_0011034 . obo:HP_0003217 obo:IAO_0000115 "An increased concentration of glutamine in the blood." ; oboInOwl:hasDbXref "UMLS:C1839533" ; oboInOwl:hasExactSynonym "High plasma glutamine" ; oboInOwl:id "HP:0003217" ; a owl:Class ; rdfs:comment "Normal glutamine blood levels are around 550-600 micromole per liter." ; rdfs:label "Hyperglutaminemia" ; rdfs:subClassOf obo:HP_0010903 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003218 obo:IAO_0000115 "An increased concentration of orotic acid in the urine." ; oboInOwl:hasAlternativeId "HP:0000810", "HP:0010928" ; oboInOwl:hasDbXref "SNOMEDCT_US:124277009", "SNOMEDCT_US:47641009", "UMLS:C0268128" ; oboInOwl:hasExactSynonym "High urine orotic acid levels", "Increased urinary orotic acid concentration" ; oboInOwl:hasRelatedSynonym "Orotic aciduria" ; oboInOwl:id "HP:0003218" ; a owl:Class ; rdfs:comment "Orotic acid is an intermediate in the biosynthesis of pyrimidine nucleotides. Some enzymatic deficiencies can cause the excretion of a large amount of orotic acid in the urine and a defect in pyrimidine biosynthesis." ; rdfs:label "Oroticaciduria" ; rdfs:subClassOf obo:HP_0031980 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003219 obo:IAO_0000115 "The concentration of ethylmalonic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C1865353" ; oboInOwl:id "HP:0003219" ; a owl:Class ; rdfs:comment "Ethylmalonic acid is a dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group." ; rdfs:label "Ethylmalonic aciduria" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_741548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003220 obo:IAO_0000115 "A type of chromosomal aberration characterised by reduced resistance of chromosomes to change or deterioration." ; oboInOwl:hasAlternativeId "HP:0002915", "HP:0008307" ; oboInOwl:hasDbXref "MSH:D019457", "UMLS:C0376628", "UMLS:C1859424" ; oboInOwl:id "HP:0003220" ; a owl:Class ; rdfs:label "Abnormality of chromosome stability" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0003221 obo:IAO_0000115 "Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with DNA cross-linking agents such as diepoxybutane and mitomycin C." ; oboInOwl:hasDbXref "UMLS:C4021737" ; oboInOwl:hasExactSynonym "Chromosomal breakage induced by diepoxybutane", "Chromosomal breakage induced by mitomycin C" ; oboInOwl:id "HP:0003221" ; a owl:Class ; rdfs:comment "Increased tendency to chromosomal breakage induced by crosslinking agents is typical for the various forms of Fanconi anemia." ; rdfs:label "Chromosomal breakage induced by crosslinking agents" ; rdfs:subClassOf obo:HP_0040012 . obo:HP_0003223 obo:IAO_0000115 "Decreased concentration of methylcobalamin. Methylcobalamin is a form of vitamin B12." ; oboInOwl:hasAlternativeId "HP:0008287" ; oboInOwl:hasDbXref "UMLS:C4021736" ; oboInOwl:hasExactSynonym "Methylcobalamin deficiency" ; oboInOwl:id "HP:0003223" ; a owl:Class ; rdfs:label "Decreased methylcobalamin" ; rdfs:subClassOf obo:HP_0040126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003224 oboInOwl:hasDbXref "UMLS:C1857707" ; oboInOwl:id "HP:0003224" ; a owl:Class ; rdfs:label "Increased cellular sensitivity to UV light" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0003225 obo:IAO_0000115 "Decreased activity of coagulation factor V." ; oboInOwl:hasDbXref "MSH:D005166", "SNOMEDCT_US:4320005", "SNOMEDCT_US:88776002", "UMLS:C0015499" ; oboInOwl:hasExactSynonym "Reduced factor V activity" ; oboInOwl:hasRelatedSynonym "Factor V deficiency" ; oboInOwl:id "HP:0003225" ; a owl:Class ; rdfs:comment "Factor V is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex." ; rdfs:label "Reduced coagulation factor V activity" ; rdfs:subClassOf obo:HP_0031899 . obo:HP_0003226 obo:IAO_0000115 "An intracellular accumulation of autofluorescent lipopigment storage material in a straight or rectilinear pattern." ; oboInOwl:hasDbXref "UMLS:C1850447" ; oboInOwl:hasExactSynonym "Rectilinear profiles ultrastructurally" ; oboInOwl:id "HP:0003226" ; a owl:Class ; rdfs:label "Rectilinear intracellular accumulation of autofluorescent lipopigment storage material" ; rdfs:subClassOf obo:HP_0003204 . obo:HP_0003228 obo:IAO_0000115 "An abnormally increased sodium concentration in the blood." ; oboInOwl:hasDbXref "MSH:D006955", "SNOMEDCT_US:286926003", "SNOMEDCT_US:39355002", "UMLS:C0020488" ; oboInOwl:hasExactSynonym "High blood sodium levels" ; oboInOwl:id "HP:0003228" ; a owl:Class ; rdfs:label "Hypernatremia" ; rdfs:subClassOf obo:HP_0010931 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003231 obo:IAO_0000115 "An increased concentration of tyrosine in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:56595005", "UMLS:C1879362" ; oboInOwl:hasExactSynonym "Increased tyrosine in blood", "Tyrosinemia" ; oboInOwl:id "HP:0003231" ; a owl:Class ; rdfs:comment "Defect in fumarylacetoacetase." ; rdfs:label "Hypertyrosinemia" ; rdfs:subClassOf obo:HP_0010917 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003232 oboInOwl:hasDbXref "UMLS:C1856697" ; oboInOwl:hasExactSynonym "Decreased mitochondrial malic enzyme" ; oboInOwl:id "HP:0003232" ; a owl:Class ; rdfs:label "Mitochondrial malic enzyme reduced" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0003233 obo:IAO_0000115 "An decreased concentration of high-density lipoprotein cholesterol in the blood." ; oboInOwl:hasDbXref "MSH:D052456", "SNOMEDCT_US:190785000", "UMLS:C0151691", "UMLS:C0473527" ; oboInOwl:hasExactSynonym "Decreased HDL cholesterol", "Decreased circulating high-density lipoprotein cholesterol", "Decreased circulating high-density lipoprotein levels", "Hypoalphalipoproteinemia", "Low HDL-cholesterol" ; oboInOwl:id "HP:0003233" ; a owl:Class ; rdfs:label "Decreased HDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010981, obo:HP_0031888 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003234 obo:IAO_0000115 "A decreased concentration of carnitine in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:421784001", "UMLS:C1142132" ; oboInOwl:hasExactSynonym "Decreased plasma carnitine" ; oboInOwl:hasRelatedSynonym "Carnitine deficiency" ; oboInOwl:id "HP:0003234" ; a owl:Class ; rdfs:comment "Carnitine is responsible for the transport of fatty acids from the cytosol into the mitochondria." ; rdfs:label "Decreased plasma carnitine" ; rdfs:subClassOf obo:HP_0003287, obo:HP_0010967 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003235 obo:IAO_0000115 "An increased concentration of methionine in the blood." ; oboInOwl:hasDbXref "MSH:C564683", "SNOMEDCT_US:124283007", "SNOMEDCT_US:43123004", "SNOMEDCT_US:57835009", "UMLS:C0268621" ; oboInOwl:hasExactSynonym "Increased methionine in blood", "Methioninemia" ; oboInOwl:id "HP:0003235" ; a owl:Class ; rdfs:comment "Elevated blood methionine levels in the range of 500-2000 micromolar." ; rdfs:label "Hypermethioninemia" ; rdfs:subClassOf obo:HP_0010901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16811 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003236 obo:IAO_0000115 "An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood. CK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy." ; oboInOwl:hasAlternativeId "HP:0002147", "HP:0002906", "HP:0003078", "HP:0003525", "HP:0003531", "HP:0008164" ; oboInOwl:hasDbXref "UMLS:C0151576", "UMLS:C0241005" ; oboInOwl:hasExactSynonym "Elevated blood creatine phosphokinase", "Elevated circulating creatine phosphokinase", "Elevated creatine kinase", "Elevated serum CPK", "Elevated serum creatine kinase", "Elevated serum creatine phosphokinase", "High serum creatine kinase", "Increased CPK", "Increased creatine kinase", "Increased creatine phosphokinase", "Increased serum CK", "Increased serum creatine kinase", "Increased serum creatine phosphokinase" ; oboInOwl:id "HP:0003236" ; a owl:Class ; rdfs:comment """'has part' some ('increased amount' and ('inheres in' some (IMR_0002602 and ('part of' some blood))) and ('has modifier' some abnormal))""" ; rdfs:label "Elevated circulating creatine kinase concentration" ; rdfs:subClassOf obo:HP_0040081 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003237 obo:IAO_0000115 "An abnormally increased level of immunoglobulin G in blood." ; oboInOwl:hasDbXref "UMLS:C1858977" ; oboInOwl:hasExactSynonym "Increased IgG level", "Increased levels of IgG", "Increased total IgG in blood" ; oboInOwl:id "HP:0003237" ; a owl:Class ; rdfs:label "Increased circulating IgG level" ; rdfs:subClassOf obo:HP_0010702, obo:HP_0410242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071736 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003238 oboInOwl:hasDbXref "UMLS:C4025638" ; oboInOwl:id "HP:0003238" ; a owl:Class ; rdfs:label "Hyperpepsinogenemia I" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0003239 obo:IAO_0000115 "An increased level of phosphoethanolamine (synonym: O-phosphoethanolamine) in the urine." ; oboInOwl:hasAlternativeId "HP:0410158" ; oboInOwl:hasDbXref "MSH:C562646", "SNOMEDCT_US:55236002", "UMLS:C0268412" ; oboInOwl:hasExactSynonym "High urine phosphoethanolamine levels", "Increased level of O-phosphoethanolamine in urine", "Increased urine O-phosphoethanolamine level" ; oboInOwl:id "HP:0003239" ; a owl:Class ; rdfs:label "Phosphoethanolaminuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36711 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003240 obo:IAO_0000115 "Abnormally elevated level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." ; oboInOwl:hasDbXref "UMLS:C4025637" ; oboInOwl:hasExactSynonym "Increased PRPS1 activity", "Increased phosphoribosyl pyrophosphate synthetase activity" ; oboInOwl:id "HP:0003240" ; a owl:Class ; rdfs:label "Increased phosphoribosylpyrophosphate synthetase level" ; rdfs:subClassOf obo:HP_0032459 . obo:HP_0003241 obo:IAO_0000115 "Underdevelopment of part or all of the external reproductive organs." ; oboInOwl:hasAlternativeId "HP:0000788", "HP:0003245" ; oboInOwl:hasDbXref "UMLS:C1855333" ; oboInOwl:hasExactSynonym "Hypogenitalism", "Small genitalia", "Underdevelopment of external reproductive organs" ; oboInOwl:id "HP:0003241" ; a owl:Class ; rdfs:comment "Partial or complete failure of the genitalia to develop, often as a consequence of hypogonadism." ; rdfs:label "External genital hypoplasia" ; rdfs:subClassOf obo:HP_0000811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003244 obo:IAO_0000115 "Location of the urethral opening on the inferior aspect of the penis." ; oboInOwl:hasDbXref "SNOMEDCT_US:204888000", "UMLS:C1691215" ; oboInOwl:id "HP:0003244" ; a owl:Class ; rdfs:label "Penile hypospadias" ; rdfs:subClassOf obo:HP_0000047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0017659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003246 obo:IAO_0000115 "Increased size of the ridge of tissue that extends along the midline of the scrotum." ; oboInOwl:hasDbXref "UMLS:C1852407" ; oboInOwl:hasExactSynonym "Prominent perineal raphe" ; oboInOwl:id "HP:0003246" ; a owl:Class ; rdfs:label "Prominent scrotal raphe" ; rdfs:subClassOf obo:HP_0000045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003247 oboInOwl:hasDbXref "UMLS:C1851722" ; oboInOwl:hasExactSynonym "Overgrowth of external genitalia" ; oboInOwl:id "HP:0003247" ; a owl:Class ; rdfs:label "Overgrowth of external genitalia" ; rdfs:subClassOf obo:HP_0000811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004176 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003248 oboInOwl:hasDbXref "UMLS:C1860268" ; oboInOwl:id "HP:0003248" ; a owl:Class ; rdfs:label "Gonadal tissue inappropriate for external genitalia or chromosomal sex" ; rdfs:subClassOf obo:HP_0000062 . obo:HP_0003249 oboInOwl:hasDbXref "UMLS:C0151281" ; oboInOwl:hasExactSynonym "Genital ulcers" ; oboInOwl:id "HP:0003249" ; a owl:Class ; rdfs:label "Genital ulcers" ; rdfs:subClassOf obo:HP_0012243 . obo:HP_0003250 obo:IAO_0000115 "Aplasia of the vagina." ; oboInOwl:hasAlternativeId "HP:0008709" ; oboInOwl:hasDbXref "MSH:C536523", "SNOMEDCT_US:248871003", "SNOMEDCT_US:87380008", "UMLS:C0220763", "UMLS:C1321884", "UMLS:C1841990" ; oboInOwl:hasExactSynonym "Absent vagina", "Congenital absence of the vagina" ; oboInOwl:id "HP:0003250" ; a owl:Class ; rdfs:label "Aplasia of the vagina" ; rdfs:subClassOf obo:HP_0011026 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003251 oboInOwl:hasDbXref "MSH:D007248", "SNOMEDCT_US:2904007", "UMLS:C0021364" ; oboInOwl:hasExactSynonym "Male infertility" ; oboInOwl:id "HP:0003251" ; a owl:Class ; rdfs:label "Male infertility" ; rdfs:subClassOf obo:HP_0000789, obo:HP_0012041 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000890 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003252 oboInOwl:hasDbXref "UMLS:C1848653" ; oboInOwl:id "HP:0003252" ; a owl:Class ; rdfs:label "Anteriorly displaced genitalia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001921 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003254 obo:IAO_0000115 "An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage." ; oboInOwl:hasDbXref "UMLS:C4021848" ; oboInOwl:id "HP:0003254" ; a owl:Class ; rdfs:label "Abnormality of DNA repair" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006281 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003256 obo:IAO_0000115 "An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators." ; oboInOwl:hasAlternativeId "HP:0001925" ; oboInOwl:hasDbXref "MSH:D001778", "SNOMEDCT_US:362970003", "SNOMEDCT_US:64779008", "UMLS:C0005779" ; oboInOwl:hasExactSynonym "Coagulopathy" ; oboInOwl:id "HP:0003256" ; a owl:Class ; rdfs:label "Abnormality of the coagulation cascade" ; rdfs:subClassOf obo:HP_0001928 . obo:HP_0003258 oboInOwl:hasDbXref "UMLS:C3279658" ; oboInOwl:id "HP:0003258" ; a owl:Class ; rdfs:label "Glyoxalase deficiency" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019172 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003259 obo:IAO_0000115 "An increased amount of creatinine in the blood." ; oboInOwl:hasAlternativeId "HP:0003227" ; oboInOwl:hasDbXref "SNOMEDCT_US:166717003", "UMLS:C0700225" ; oboInOwl:hasExactSynonym "Elevated creatinine", "Elevated serum creatinine", "High blood creatinine level", "Increased creatinine", "Increased serum creatinine" ; oboInOwl:id "HP:0003259" ; a owl:Class ; rdfs:label "Elevated circulating creatinine concentration" ; rdfs:subClassOf obo:HP_0002157, obo:HP_0012100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003260 obo:IAO_0000115 "An increased concentration of hydroxyproline in the blood." ; oboInOwl:hasDbXref "MSH:C562669", "SNOMEDCT_US:25739007", "UMLS:C0268531" ; oboInOwl:hasExactSynonym "High blood hydroxyproline levels" ; oboInOwl:id "HP:0003260" ; a owl:Class ; rdfs:comment "Hydroxyproline is an imino acid normally present in human plasma and is derived primarily from endogenous collagen turnover and the breakdown of dietary collagen. Hyperhydroxyprolinemic patients show hydroxyproline blood levels between 150 and 500 micromole per liter. Normal levels are around 10-20 micromole per liter." ; rdfs:label "Hydroxyprolinemia" ; rdfs:subClassOf obo:HP_0010907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003261 obo:IAO_0000115 "An abnormally increased level of immunoglobulin A in blood." ; oboInOwl:hasAlternativeId "HP:0004436", "HP:0005351", "HP:0005417" ; oboInOwl:hasDbXref "UMLS:C0239984" ; oboInOwl:hasExactSynonym "Elevated IgA", "Elevated serum IgA", "IgA hypergammaglobulinemia", "Increased levels of IgA", "Increased serum IgA" ; oboInOwl:id "HP:0003261" ; a owl:Class ; rdfs:label "Increased circulating IgA level" ; rdfs:subClassOf obo:HP_0010702, obo:HP_0410240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003262 obo:IAO_0000115 "The presence in serum of antibodies against smooth muscle." ; oboInOwl:hasDbXref "SNOMEDCT_US:310290006", "UMLS:C0241185" ; oboInOwl:hasExactSynonym "Anti-smooth muscle antibody positivity", "Smooth muscle antibody positive" ; oboInOwl:id "HP:0003262" ; a owl:Class ; rdfs:comment "Anti smooth muscle antibody (SMA) may be present in a number of conditions including chronic active hepatitis, autoimmune hepatitis, cirrhosis, and infectious mononucleosis." ; rdfs:label "Smooth muscle antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0003264 oboInOwl:hasDbXref "MSH:D009081", "SNOMEDCT_US:70199000", "UMLS:C0020725" ; oboInOwl:id "HP:0003264" ; a owl:Class ; rdfs:comment "N-acetylglucosamine-1-phosphotransferase catalyzes the initial step in the synthesis of the mannose 6-phosphate determinant required for efficient intracellular targeting of newly synthesized lysosomal hydrolases to the lysosome." ; rdfs:label "Deficiency of N-acetylglucosamine-1-phosphotransferase" ; rdfs:subClassOf obo:HP_0004356 . obo:HP_0003265 obo:IAO_0000115 "A type of hyperbilirubinemia with neonatal onset." ; oboInOwl:hasAlternativeId "HP:0008152" ; oboInOwl:hasDbXref "MSH:D051556", "SNOMEDCT_US:281610001", "UMLS:C0857007" ; oboInOwl:hasExactSynonym "High blood bilirubin levels in neonate", "Hyperbilirubinemia, neonatal" ; oboInOwl:id "HP:0003265" ; a owl:Class ; rdfs:label "Neonatal hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0002904 . obo:HP_0003267 obo:IAO_0000115 "An abnormal decrease in orotidine 5'-phosphate decarboxylase level." ; oboInOwl:hasDbXref "UMLS:C4020845", "UMLS:C4025636" ; oboInOwl:hasRelatedSynonym "Orotidine-5-prime-phosphate decarboxylase defect" ; oboInOwl:id "HP:0003267" ; a owl:Class ; rdfs:comment "The enzyme orotidine-5-prime-phosphate decarboxylase (EC 4.1.1.23) catalyzes the reaction H(+) + orotidine 5'-phosphate = CO(2) + UMP (uridine monophosphate). The enzyme is thusinvolved in pyrimidine biosynthesis." ; rdfs:label "Reduced orotidine 5-prime phosphate decarboxylase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000023661 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003268 obo:IAO_0000115 "A increased concentration of arginine in the urine." ; oboInOwl:hasDbXref "UMLS:C4025635" ; oboInOwl:hasExactSynonym "High urine arginine levels" ; oboInOwl:id "HP:0003268" ; a owl:Class ; rdfs:comment "Normal urinary arginine total (free and combined form) excretion is around 30 mg per 24 hours." ; rdfs:label "Argininuria" ; rdfs:subClassOf obo:HP_0033093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003269 oboInOwl:hasDbXref "MSH:D020371", "SNOMEDCT_US:64855000", "UMLS:C0205711" ; oboInOwl:id "HP:0003269" ; a owl:Class ; rdfs:label "Sudanophilic leukodystrophy" ; rdfs:subClassOf obo:HP_0002415 . obo:HP_0003270 obo:IAO_0000115 "Distention of the abdomen." ; oboInOwl:hasAlternativeId "HP:0001542", "HP:0003364" ; oboInOwl:hasDbXref "SNOMEDCT_US:41931001", "SNOMEDCT_US:60728008", "UMLS:C0000731" ; oboInOwl:hasExactSynonym "Abdominal bloating", "Abdominal distension", "Abdominal swelling", "Belly bloating", "Bloating", "Distended abdomen" ; oboInOwl:id "HP:0003270" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Abdominal distention can be a secondary feature associated with a number of conditions such as bowel obstruction." ; rdfs:label "Abdominal distention" ; rdfs:subClassOf obo:HP_0011458 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001602 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003271 obo:IAO_0000115 "Abnormal increased size of the viscera of the abdomen." ; oboInOwl:hasDbXref "SNOMEDCT_US:28543008", "UMLS:C0042782" ; oboInOwl:id "HP:0003271" ; a owl:Class ; rdfs:comment "Visceromegaly is enlargement of the internal organs in the abdomen, including liver, spleen, stomach, kidneys, or pancreas." ; rdfs:label "Visceromegaly" ; rdfs:subClassOf obo:HP_0001438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0017672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003272 obo:IAO_0000115 "An abnormality of the hip bone." ; oboInOwl:hasDbXref "UMLS:C4021735" ; oboInOwl:hasExactSynonym "Abnormality of the hip bone", "Abnormality of the hips" ; oboInOwl:id "HP:0003272" ; a owl:Class ; rdfs:comment "The hip region comprises the vasculature of hip, skin of hip, superficial fascia of hip, the hip bone, hip joint, and musculature of hip. The hip is part of the pelvic girdle." ; rdfs:label "Abnormal hip bone morphology" ; rdfs:subClassOf obo:HP_0002644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001272 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003273 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the hip joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." ; oboInOwl:hasDbXref "SNOMEDCT_US:202283002", "UMLS:C0409354" ; oboInOwl:hasExactSynonym "Flexion contracture of hips", "Flexion contractures of hips", "Hip contractures", "Hip flexion contractures" ; oboInOwl:id "HP:0003273" ; a owl:Class ; rdfs:label "Hip contracture" ; rdfs:subClassOf obo:HP_0001384, obo:HP_0005750 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003274 obo:IAO_0000115 "Underdeveloped acetabulae." ; oboInOwl:hasDbXref "UMLS:C1846442" ; oboInOwl:hasExactSynonym "Acetabular hypoplasia", "Hypoplastic acetabula" ; oboInOwl:id "HP:0003274" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic acetabulae" ; rdfs:subClassOf obo:HP_0003170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001269 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003275 obo:IAO_0000115 "Reduced side to side width of the pelvis." ; oboInOwl:hasBroadSynonym "Narrow pelvis" ; oboInOwl:hasDbXref "UMLS:C1848103" ; oboInOwl:hasExactSynonym "Narrow pelvis bone" ; oboInOwl:id "HP:0003275" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow pelvis bone" ; rdfs:subClassOf obo:HP_0040163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003276 obo:IAO_0000115 "A benign growth the projects outward from the bone surface of the pelvis. Exostoses are capped by cartilage, and arise from a bone that develops from cartilage." ; oboInOwl:hasBroadSynonym "Pelvic exostoses" ; oboInOwl:hasDbXref "UMLS:C1844689" ; oboInOwl:id "HP:0003276" ; a owl:Class ; rdfs:label "Pelvic bone exostoses" ; rdfs:subClassOf obo:HP_0040163, obo:HP_0100777 . obo:HP_0003277 oboInOwl:hasDbXref "UMLS:C1854785" ; oboInOwl:hasExactSynonym "Constricted iliac wings" ; oboInOwl:id "HP:0003277" ; a owl:Class ; rdfs:label "Constricted iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003278 obo:IAO_0000115 "An abnormally squared appearance of the bony pelvis, a normally rounded or basin-shaped structure." ; oboInOwl:hasBroadSynonym "Square pelvis" ; oboInOwl:hasDbXref "UMLS:C1849953" ; oboInOwl:hasExactSynonym "Square pelvis bone" ; oboInOwl:hasRelatedSynonym "Squared off pelvis" ; oboInOwl:id "HP:0003278" ; a owl:Class ; rdfs:label "Square pelvis bone" ; rdfs:subClassOf obo:HP_0040163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000413 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003279 obo:IAO_0000115 "Widening of the femoral head and neck." ; oboInOwl:hasDbXref "MSH:D000070603", "SNOMEDCT_US:296041000119103", "UMLS:C1860826" ; oboInOwl:id "HP:0003279" ; a owl:Class ; rdfs:comment "Coxa magna can occur as a result of developmental dysplasia of the hip, Perthes disease, septic arthritis, Kniest dysplasia, among others." ; rdfs:label "Coxa magna" ; rdfs:subClassOf obo:HP_0003272 . obo:HP_0003281 obo:IAO_0000115 "Increased concentration of ferritin in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C0241013", "UMLS:C0743912", "UMLS:C3854388" ; oboInOwl:hasExactSynonym "Elevated serum ferritin", "High ferritin level", "Hyperferritinaemia", "Hyperferritinemia", "Increased ferritin", "Increased plasma ferritin", "Increased serum ferritin level" ; oboInOwl:id "HP:0003281" ; a owl:Class ; rdfs:comment "Ferritin is a ubiquitous intracellular protein that stores iron. Ferritin levels measured in serum usually have a direct correlation with the total amount of iron stored in the body, but ferritin levels may also be increased with anemia of chronic disease or in the course of an acute phase reaction." ; rdfs:label "Increased circulating ferritin concentration" ; rdfs:subClassOf obo:HP_0033331, obo:HP_0040133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070288 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003282 obo:IAO_0000115 "Abnormally reduced serum levels of alkaline phosphatase." ; oboInOwl:hasDbXref "UMLS:C1860130" ; oboInOwl:hasExactSynonym "Decreased serum alkaline phosphatase", "Low ALP" ; oboInOwl:id "HP:0003282" ; a owl:Class ; rdfs:label "Low alkaline phosphatase" ; rdfs:subClassOf obo:HP_0004379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003286 obo:IAO_0000115 "An increased concentration of cystathionine in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:6669004", "UMLS:C0268618" ; oboInOwl:hasExactSynonym "High blood cystathionine levels" ; oboInOwl:id "HP:0003286" ; a owl:Class ; rdfs:comment "Cystathionine can be directly interconverted to cysteine. Cystathionine is not normally detectable in plasma." ; rdfs:label "Cystathioninemia" ; rdfs:subClassOf obo:HP_0033108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17755 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003287 obo:IAO_0000115 "A functional anomaly of mitochondria." ; oboInOwl:hasDbXref "UMLS:C4021734" ; oboInOwl:hasExactSynonym "Mitochondrial dysfunction" ; oboInOwl:id "HP:0003287" ; a owl:Class ; rdfs:label "Abnormality of mitochondrial metabolism" ; rdfs:subClassOf obo:HP_0012103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0008152 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005739 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003288 oboInOwl:hasDbXref "UMLS:C4025634" ; oboInOwl:hasExactSynonym "Mitochondrial PCC defect" ; oboInOwl:id "HP:0003288" ; a owl:Class ; rdfs:label "Mitochondrial propionyl-CoA carboxylase defect" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0003292 obo:IAO_0000115 "A decreased concentration of leptin in the blood." ; oboInOwl:hasDbXref "UMLS:C1837802" ; oboInOwl:hasExactSynonym "Decreased serum leptin", "Reduced circulating leptin level" ; oboInOwl:id "HP:0003292" ; a owl:Class ; rdfs:comment "Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis." ; rdfs:label "Decreased serum leptin" ; rdfs:subClassOf obo:HP_0004361 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009758 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003295 oboInOwl:consider "HP:0030339" ; oboInOwl:id "HP:0003295" ; a owl:Class ; rdfs:label "obsolete Impaired FSH and LH secretion" ; owl:deprecated true . obo:HP_0003296 obo:IAO_0000115 "An increased concentration of threonine in the urine." ; oboInOwl:hasDbXref "UMLS:C2673931" ; oboInOwl:hasExactSynonym "High urine threonine levels" ; oboInOwl:id "HP:0003296" ; a owl:Class ; rdfs:comment "Normal urinary threonine total (free and combined form) excretion is around 50 mg per 24 hours." ; rdfs:label "Hyperthreoninuria" ; rdfs:subClassOf obo:HP_0033096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003297 obo:IAO_0000115 "An increased concentration of lysine in the urine." ; oboInOwl:hasAlternativeId "HP:0002158" ; oboInOwl:hasDbXref "UMLS:C4021733" ; oboInOwl:hasExactSynonym "High urine lysine levels", "Lysinuria" ; oboInOwl:id "HP:0003297" ; a owl:Class ; rdfs:comment "Normal urinary lysine total (free and combined form) excretion is around 80 mg per 24 hours." ; rdfs:label "Hyperlysinuria" ; rdfs:subClassOf obo:HP_0033096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003298 obo:IAO_0000115 "The closed form of spina bifida with incomplete closure of a vertebral body with intact overlying skin." ; oboInOwl:hasDbXref "MSH:D016136", "SNOMEDCT_US:76916001", "UMLS:C0080174" ; oboInOwl:id "HP:0003298" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "May be asymptomatic." ; rdfs:label "Spina bifida occulta" ; rdfs:subClassOf obo:HP_0002414 . obo:HP_0003300 obo:IAO_0000115 "When viewed in lateral radiographs, vertebral bodies have a roughly rectangular configuration. This term applies if the vertebral body appears rounded or oval." ; oboInOwl:hasAlternativeId "HP:0004559" ; oboInOwl:hasDbXref "UMLS:C1855665", "UMLS:C4020844" ; oboInOwl:hasExactSynonym "Oval vertebral bodies", "Ovoid vertebrae", "Ovoid-shaped vertebral bodies" ; oboInOwl:hasRelatedSynonym "Bullet vertebral body" ; oboInOwl:id "HP:0003300" ; a owl:Class ; rdfs:label "Ovoid vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001891 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003301 obo:IAO_0000115 "An irregular surface of the vertebral end plates, which are normally relatively smooth." ; oboInOwl:hasAlternativeId "HP:0003420", "HP:0004583", "HP:0004628" ; oboInOwl:hasDbXref "UMLS:C1842153" ; oboInOwl:hasExactSynonym "Irregular end plates", "Irregular endplates", "end-plate irregularities", "endplate irregularities", "endplate irregularity", "irregular vertebral plates", "vertebral endplate irregularity" ; oboInOwl:id "HP:0003301" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Irregular vertebral endplates" ; rdfs:subClassOf obo:HP_0005106 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003302 obo:IAO_0000115 "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra." ; oboInOwl:hasDbXref "MSH:D013168", "SNOMEDCT_US:274152003", "UMLS:C0038016" ; oboInOwl:hasExactSynonym "Displacement of one backbone compared to another", "Slipped backbone", "Spondylolithesis" ; oboInOwl:id "HP:0003302" ; a owl:Class ; rdfs:label "Spondylolisthesis" ; rdfs:subClassOf obo:HP_0000925 . obo:HP_0003304 obo:IAO_0000115 "Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma." ; oboInOwl:hasDbXref "MSH:D013169", "SNOMEDCT_US:240221008", "UMLS:C0038018" ; oboInOwl:id "HP:0003304" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The pars interarticularis is one of the bony bridges that connect the upper with the lower facet joints of the vertebra. Lumbar spondylolysis is a common cause of lower back pain. The vast majority of cases of spondylolysis occur at the L5 or L4 levels, and is usually diagnosed radiographically. Over half of patients affected by spondylolysis have associated spondylolisthesis." ; rdfs:label "Spondylolysis" ; rdfs:subClassOf obo:HP_0000925 . obo:HP_0003305 obo:IAO_0000115 "Congenital synostosis between two or more adjacent vertebrae (partial or complete fusion of adjacent vertabral bodies)." ; oboInOwl:hasDbXref "UMLS:C1844753" ; oboInOwl:id "HP:0003305" ; a owl:Class ; rdfs:label "Block vertebrae" ; rdfs:subClassOf obo:HP_0002948 . obo:HP_0003306 obo:IAO_0000115 "Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion." ; oboInOwl:hasDbXref "UMLS:C1858025" ; oboInOwl:hasExactSynonym "Reduced spine movement", "Rigid spine" ; oboInOwl:id "HP:0003306" ; a owl:Class ; rdfs:label "Spinal rigidity" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002063 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003307 obo:IAO_0000115 "Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine." ; oboInOwl:hasAlternativeId "HP:0002939" ; oboInOwl:hasDbXref "MSH:D008141", "SNOMEDCT_US:249710008", "SNOMEDCT_US:61960001", "UMLS:C0024003" ; oboInOwl:hasExactSynonym "Lordosis", "Prominent swayback" ; oboInOwl:id "HP:0003307" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hyperlordosis" ; rdfs:subClassOf obo:HP_0010674 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001469 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0003308 obo:IAO_0000115 "A partial dislocation of one or more intervertebral joints in the cervical vertebral column." ; oboInOwl:hasDbXref "UMLS:C1846798" ; oboInOwl:id "HP:0003308" ; a owl:Class ; rdfs:label "Cervical subluxation" ; rdfs:subClassOf obo:HP_0003319, obo:HP_0032153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003309 oboInOwl:hasDbXref "UMLS:C1868556" ; oboInOwl:hasExactSynonym "Ovoid thoracic and lumbar vertebrae" ; oboInOwl:id "HP:0003309" ; a owl:Class ; rdfs:label "Ovoid thoracolumbar vertebrae" ; rdfs:subClassOf obo:HP_0003300 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001891 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003310 obo:IAO_0000115 "Abnormal structure of the odontoid process, which is a part of the C2 or axis vertebra and forms pivot of the structures forming the craniovertebral junction. The odontoid process is also known as the dens of the axis." ; oboInOwl:hasAlternativeId "HP:0004600" ; oboInOwl:hasDbXref "UMLS:C1864794" ; oboInOwl:hasExactSynonym "Abnormal odontoid peg", "Abnormal odontoid process", "Abnormality of the odontoid process" ; oboInOwl:id "HP:0003310" ; a owl:Class ; rdfs:comment "The dens of the axis is a protuberance of the C2 vertebral body around which the first vertebra rotates." ; rdfs:label "Abnormal odontoid process morphology" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003311 obo:IAO_0000115 "Developmental hypoplasia of the dens of the axis." ; oboInOwl:hasAlternativeId "HP:0003299", "HP:0004613", "HP:0008481" ; oboInOwl:hasDbXref "UMLS:C1846439" ; oboInOwl:hasExactSynonym "Hypoplastic odontoid process", "Odontoid hypoplasia", "Small odontoid peg", "Small odontoid process" ; oboInOwl:id "HP:0003311" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the odontoid process" ; rdfs:subClassOf obo:HP_0003310, obo:HP_0008518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003312 obo:IAO_0000115 "Abnormal morphology of vertebral body." ; oboInOwl:hasDbXref "UMLS:C1839326" ; oboInOwl:hasExactSynonym "Abnormally shaped vertebrae" ; oboInOwl:id "HP:0003312" ; a owl:Class ; rdfs:label "Abnormal form of the vertebral bodies" ; rdfs:subClassOf obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003316 obo:IAO_0000115 "A butterfly vertebra (sagittal cleft vertebra or anterior rachischisis) is a sagittal defect in the vertebral body caused by failure of fusion of the two lateral chondrification centers during embryogenesis. The name is based on the appearance of the two hemivertebrae emerging as butterfly wings from the central cleft on x-ray." ; oboInOwl:hasDbXref "UMLS:C1844752" ; oboInOwl:hasExactSynonym "Anterior rachischisis", "Butterfly vertebrae", "Sagittal clefting of vertebrae" ; oboInOwl:id "HP:0003316" ; a owl:Class ; rdfs:label "Butterfly vertebrae" ; rdfs:subClassOf obo:HP_0008428 . obo:HP_0003318 oboInOwl:hasDbXref "SNOMEDCT_US:298186005", "UMLS:C0574967" ; oboInOwl:hasExactSynonym "Cervical spine joint hypermobility" ; oboInOwl:id "HP:0003318" ; a owl:Class ; rdfs:label "Cervical spine hypermobility" ; rdfs:subClassOf obo:HP_0003319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003319 obo:IAO_0000115 "Any abnormality of the cervical vertebral column." ; oboInOwl:hasAlternativeId "HP:0004587" ; oboInOwl:hasDbXref "UMLS:C1852464" ; oboInOwl:hasExactSynonym "Abnormal cervical spine", "Abnormality of cervical vertebra", "Abnormality of the cervical vertebrae", "Cervical spine abnormalities", "Cervical vertebral abnormalities", "Disorder of cervical vertebra" ; oboInOwl:hasRelatedSynonym "Cervical vertebral anomalies" ; oboInOwl:id "HP:0003319" ; a owl:Class ; rdfs:label "Abnormality of the cervical spine" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003320 obo:IAO_0000115 "A partial dislocation of the atlantoaxial joints." ; oboInOwl:hasDbXref "UMLS:C1848446" ; oboInOwl:id "HP:0003320" ; a owl:Class ; rdfs:comment "A subluxation affecting the intervertebral joint between the first and second cervical vertebrae." ; rdfs:label "C1-C2 subluxation" ; rdfs:subClassOf obo:HP_0003308, obo:HP_0008440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001093 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003321 oboInOwl:hasAlternativeId "HP:0005782" ; oboInOwl:hasDbXref "UMLS:C1833753" ; oboInOwl:id "HP:0003321" ; a owl:Class ; rdfs:label "Biconcave flattened vertebrae" ; rdfs:subClassOf obo:HP_0000926, obo:HP_0004586 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000926 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003323 oboInOwl:hasAlternativeId "HP:0009032" ; oboInOwl:hasDbXref "UMLS:C0240421" ; oboInOwl:hasExactSynonym "Muscle weakness, progressive", "Progressive muscular weakness" ; oboInOwl:id "HP:0003323" ; a owl:Class ; rdfs:label "Progressive muscle weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0003324 obo:IAO_0000115 "Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature." ; oboInOwl:hasAlternativeId "HP:0003686", "HP:0003723" ; oboInOwl:hasDbXref "UMLS:C0746674" ; oboInOwl:hasExactSynonym "Generalised muscle weakness", "Generalised weakness", "Generalized weakness", "Muscle weakness, diffuse", "Muscle weakness, generalised", "Muscle weakness, generalized" ; oboInOwl:id "HP:0003324" ; a owl:Class ; rdfs:label "Generalized muscle weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0003325 obo:IAO_0000115 "Weakness of the limb-girdle muscles (also known as the pelvic and shoulder girdles), that is, lack of strength of the muscles around the shoulders and the pelvis." ; oboInOwl:hasAlternativeId "HP:0008971" ; oboInOwl:hasDbXref "UMLS:C1858127" ; oboInOwl:hasExactSynonym "Limb girdle weakness", "Muscle weakness, limb-girdle", "Muscular weakness, limb-girdle" ; oboInOwl:id "HP:0003325" ; a owl:Class ; rdfs:label "Limb-girdle muscle weakness" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004470 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004471 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004480 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003326 obo:IAO_0000115 "Pain in muscle." ; oboInOwl:hasAlternativeId "HP:0003718" ; oboInOwl:hasDbXref "MSH:D063806", "SNOMEDCT_US:68962001", "UMLS:C0231528" ; oboInOwl:hasExactSynonym "Muscle ache", "Muscle pain" ; oboInOwl:hasRelatedSynonym "Myalgias" ; oboInOwl:id "HP:0003326" ; a owl:Class ; rdfs:label "Myalgia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0003327 obo:IAO_0000115 "Reduced strength of the axial musculature (i.e., of the muscles of the head and neck, spine, and ribs)." ; oboInOwl:hasDbXref "UMLS:C1843697" ; oboInOwl:id "HP:0003327" ; a owl:Class ; rdfs:label "Axial muscle weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003897 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003328 obo:IAO_0000115 "An abnormal structure of the hairshaft, i.e., of the nongrowing portion of a hair that protrudes from the skin." ; oboInOwl:hasDbXref "UMLS:C4025632" ; oboInOwl:id "HP:0003328" ; a owl:Class ; rdfs:label "Abnormal hairshaft morphology" ; rdfs:subClassOf obo:HP_0001595 . obo:HP_0003329 oboInOwl:hasDbXref "UMLS:C4025631" ; oboInOwl:id "HP:0003329" ; a owl:Class ; rdfs:label "Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0003330 obo:IAO_0000115 "Any anomaly in the composite material or the layered arrangement of the bony skeleton." ; oboInOwl:hasDbXref "UMLS:C4025630" ; oboInOwl:id "HP:0003330" ; a owl:Class ; rdfs:label "Abnormal bone structure" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003332 oboInOwl:hasDbXref "UMLS:C3277126" ; oboInOwl:id "HP:0003332" ; a owl:Class ; rdfs:label "Absent primary metaphyseal spongiosa" ; rdfs:subClassOf obo:HP_0005089 . obo:HP_0003333 oboInOwl:hasAlternativeId "HP:0008299" ; oboInOwl:hasDbXref "UMLS:C2673361" ; oboInOwl:id "HP:0003333" ; a owl:Class ; rdfs:comment "This enzyme removes a beta-1,4-linked N-acetylhexosamine residue from the GM2 ganglioside." ; rdfs:label "Increased serum beta-hexosaminidase" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0003334 obo:IAO_0000115 "An abnormal increase in catecholamine concentration in the blood." ; oboInOwl:hasDbXref "UMLS:C4025629" ; oboInOwl:id "HP:0003334" ; a owl:Class ; rdfs:comment "Elevated circulating catecholamine level is a common feature in patients with pheochromocytoma." ; rdfs:label "Elevated circulating catecholamine level" ; rdfs:subClassOf obo:HP_0012099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003335 obo:IAO_0100001 "HP:0000044" ; oboInOwl:id "HP:0003335" ; a owl:Class ; rdfs:label "obsolete Low gonadotropins (secondary hypogonadism)" ; owl:deprecated true . obo:HP_0003336 obo:IAO_0000115 "An abnormality of the process of endochondral ossification, which is a type of replacement ossification in which bone tissue replaces cartilage." ; oboInOwl:hasAlternativeId "HP:0003331" ; oboInOwl:hasDbXref "UMLS:C4025628" ; oboInOwl:id "HP:0003336" ; a owl:Class ; rdfs:comment "This term is intended to describe histological abnormalities of enchondral ossification observed upon bone biopsy." ; rdfs:label "Abnormal enchondral ossification" ; rdfs:subClassOf obo:HP_0011849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003337 obo:IAO_0000115 "The prothrombin consumption test measures the formation of intrinsic thromboplastin by determining the residual serum prothrombin after blood clotting is complete. If there is a defect in the process, less prothrombin will be converted to thrombin than normal (less prothrombin is consumed). This test may be abnormal with conditions including deficiency of factors VIII or IX, with circulating anticoagulants, thrombocytopenia." ; oboInOwl:hasAlternativeId "HP:0008172" ; oboInOwl:hasDbXref "UMLS:C4021732" ; oboInOwl:hasExactSynonym "Poor prothrombin consumption" ; oboInOwl:id "HP:0003337" ; a owl:Class ; rdfs:label "Reduced prothrombin consumption" ; rdfs:subClassOf obo:HP_0012200 . obo:HP_0003338 oboInOwl:hasDbXref "UMLS:C4025627" ; oboInOwl:id "HP:0003338" ; a owl:Class ; rdfs:label "Focal necrosis of right ventricular muscle cells" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0003339 obo:IAO_0000115 "A type of megaloblastic anemia that improves upon administration of pyrimidine supplements such as uridylic acid and cytidylic acid." ; oboInOwl:hasDbXref "UMLS:C4021731" ; oboInOwl:hasExactSynonym "Anaemia corrected by uridylic acid and cytidylic acid", "Anemia corrected by uridylic acid and cytidylic acid", "Pyrimidine-responsive megaloblastic anaemia" ; oboInOwl:id "HP:0003339" ; a owl:Class ; rdfs:label "Pyrimidine-responsive megaloblastic anemia" ; rdfs:subClassOf obo:HP_0001889 . obo:HP_0003340 oboInOwl:consider "HP:0000951" ; oboInOwl:id "HP:0003340" ; a owl:Class ; rdfs:label "obsolete Abnormal dermatological laboratory findings" ; owl:deprecated true . obo:HP_0003341 obo:IAO_0000115 "The formation of bullae (blisters) with cleavage in the lamina lucida layer of the skin." ; oboInOwl:hasDbXref "UMLS:C4021730" ; oboInOwl:hasExactSynonym "Blistering with junctional split", "Junctional split", "Subepidermal blistering with cleavage in the lamina lucida" ; oboInOwl:id "HP:0003341" ; a owl:Class ; rdfs:comment "Cleavage within the lamina lucida is observed in junctional epidermolysis bullosa." ; rdfs:label "Lamina lucida cleavage" ; rdfs:subClassOf obo:HP_0033804 . obo:HP_0003343 obo:IAO_0000115 "Reduced level of the enzyme glutathione synthetase, which catalyzes the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione. Acidosis is due to reduced feedback inhibition of gamma-glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline." ; oboInOwl:hasDbXref "MSH:C536835", "SNOMEDCT_US:124706000", "SNOMEDCT_US:234589002", "SNOMEDCT_US:39112005", "UMLS:C0398746" ; oboInOwl:hasExactSynonym "Glutathione synthetase deficiency" ; oboInOwl:id "HP:0003343" ; a owl:Class ; rdfs:label "Reduced glutathione synthetase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0003344 obo:IAO_0000115 "An abnormally increased level of 3-hydroxy-3-methylglutaric acid in the urine." ; oboInOwl:hasDbXref "UMLS:C3151952" ; oboInOwl:hasExactSynonym "3-methylglutaricaciduria" ; oboInOwl:id "HP:0003344" ; a owl:Class ; rdfs:label "3-Methylglutaric aciduria" ; rdfs:subClassOf obo:HP_0031980 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_68566 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003345 obo:IAO_0000115 "The concentration of noradrenaline in the urine, normalized for urine concentration, is above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C4025626" ; oboInOwl:id "HP:0003345" ; a owl:Class ; rdfs:label "Elevated urinary norepinephrine level" ; rdfs:subClassOf obo:HP_0011976 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33569 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003347 obo:IAO_0000115 "Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes." ; oboInOwl:hasDbXref "UMLS:C4025625" ; oboInOwl:id "HP:0003347" ; a owl:Class ; rdfs:comment "The response of lymphocytes to PHA is measured by their ability to transform and to undergo mitosis." ; rdfs:label "Impaired lymphocyte transformation with phytohemagglutinin" ; rdfs:subClassOf obo:HP_0004332 . obo:HP_0003348 obo:IAO_0000115 "An increased concentration of alanine in the blood." ; oboInOwl:hasDbXref "MSH:C562684", "SNOMEDCT_US:2359002", "UMLS:C0268630", "UMLS:C1839424", "UMLS:C1849489" ; oboInOwl:hasExactSynonym "Increased blood alanine", "Increased serum alanine" ; oboInOwl:id "HP:0003348" ; a owl:Class ; rdfs:comment "This class referring to the clinical feature Hyperalaninemia and not to the disease entry. Normal alanine blood levels are around 350-400 micromole per liter." ; rdfs:label "Hyperalaninemia" ; rdfs:subClassOf obo:HP_0010916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003349 obo:IAO_0000115 "A reduction in the rate of cholesterol esterification." ; oboInOwl:hasDbXref "UMLS:C1843371" ; oboInOwl:id "HP:0003349" ; a owl:Class ; rdfs:comment "Cholesterol esterification convers free cholesterol to cholesteryl esters between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol. Esterification allows more cholesterol to be packaged into the interior of lipoproteins. Cholesterol esterification rates can be measured in skin fibroblasts using for instance a non-lipoprotein [3H]cholesterol source." ; rdfs:label "Low cholesterol esterification rate" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0034435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003351 obo:IAO_0000115 "An decreased level of renin in the blood." ; oboInOwl:hasAlternativeId "HP:0003263" ; oboInOwl:hasDbXref "UMLS:C1845206" ; oboInOwl:hasExactSynonym "Decreased plasma renin activity", "Low plasma renin activity", "Suppressed plasma renin activity" ; oboInOwl:id "HP:0003351" ; a owl:Class ; rdfs:label "Decreased circulating renin level" ; rdfs:subClassOf obo:HP_0040084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000013883 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003352 obo:IAO_0000115 "An increase in the number of chromosome sets per cell in bone marrow cells." ; oboInOwl:hasDbXref "UMLS:C4025624" ; oboInOwl:id "HP:0003352" ; a owl:Class ; rdfs:comment "Endopolyploidy is caused by replication without cell division." ; rdfs:label "Endopolyploidy on chromosome studies of bone marrow" ; rdfs:subClassOf obo:HP_0002916 . obo:HP_0003353 obo:IAO_0000115 "An abnormality of amino acid metabolism characterized by a decreased level of propionyl-CoA carboxylase." ; oboInOwl:hasDbXref "MSH:D056693", "SNOMEDCT_US:124718009", "SNOMEDCT_US:69080001", "UMLS:C0268579" ; oboInOwl:id "HP:0003353" ; a owl:Class ; rdfs:comment "Propionyl-CoA is an important intermediate in the metabolism of several amino acids and is also produced by oxidation of odd-numbered fatty acids." ; rdfs:label "Propionyl-CoA carboxylase deficiency" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004658 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003354 obo:IAO_0000115 "An increased concentration of threonine in the blood." ; oboInOwl:hasDbXref "UMLS:C1848861" ; oboInOwl:hasExactSynonym "Elevated circulating threonine", "High blood threonine levels" ; oboInOwl:id "HP:0003354" ; a owl:Class ; rdfs:label "Hyperthreoninemia" ; rdfs:subClassOf obo:HP_0010900 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003355 obo:IAO_0000115 "An increased concentration of an amino acid in the urine." ; oboInOwl:hasAlternativeId "HP:0002903", "HP:0008335", "HP:0200014" ; oboInOwl:hasDbXref "SNOMEDCT_US:35912001", "UMLS:C0238621", "UMLS:C4020843" ; oboInOwl:hasExactSynonym "High urine amino acid levels", "Hyperaminoaciduria", "Increased levels of animo acids in urine" ; oboInOwl:hasRelatedSynonym "Abnormal urinary amino-acid findings" ; oboInOwl:id "HP:0003355" ; a owl:Class ; rdfs:label "Aminoaciduria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33709 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003357 obo:IAO_0000115 "A reduction in the level of thymic horomone." ; oboInOwl:hasDbXref "UMLS:C1857652" ; oboInOwl:hasExactSynonym "Decreased thymic hormone" ; oboInOwl:id "HP:0003357" ; a owl:Class ; rdfs:label "Thymic hormone decreased" ; rdfs:subClassOf obo:HP_0000777 . obo:HP_0003358 obo:IAO_0000115 "An increased concentration of cystine within cells. This finding can be demonstrated on leukocytes, but is not specific to blood cells." ; oboInOwl:hasDbXref "UMLS:C4025623" ; oboInOwl:id "HP:0003358" ; a owl:Class ; rdfs:comment "Cystine is a dimeric amino acid formed by the oxidation of two cysteine residues to form a disulfide bond." ; rdfs:label "Elevated intracellular cystine" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003359 obo:IAO_0000115 "Decreased concentration of sulfate in the urine." ; oboInOwl:hasDbXref "UMLS:C1848958" ; oboInOwl:hasExactSynonym "Decreased urinary sulfate", "Decreased urinary sulphate" ; oboInOwl:id "HP:0003359" ; a owl:Class ; rdfs:label "Decreased urinary sulfate" ; rdfs:subClassOf obo:HP_0012612 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16189 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003361 obo:IAO_0000115 "An increased concentration of tryptophan in the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:18789002", "UMLS:C0268472" ; oboInOwl:hasExactSynonym "High urine tryptophan levels" ; oboInOwl:id "HP:0003361" ; a owl:Class ; rdfs:comment "Normal urinary tryptophan total (free and combined form) excretion is around 40 mg per 24 hours." ; rdfs:label "Tryptophanuria" ; rdfs:subClassOf obo:HP_0033090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003362 obo:IAO_0000115 "An increase in the amount of very-low-density lipoprotein cholesterol in the blood." ; oboInOwl:hasDbXref "UMLS:C4021729" ; oboInOwl:hasExactSynonym "Increased circulating very-low-density lipoprotein cholesterol", "Increased circulating very-low-density lipoprotein levels", "Increased plasma VLDL cholesterol" ; oboInOwl:id "HP:0003362" ; a owl:Class ; rdfs:label "Increased VLDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010980, obo:HP_0031889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47773 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003363 obo:IAO_0000115 "A left-right reversal (or \"mirror reflection\") of the anatomical location of the viscera of the abdomen." ; oboInOwl:hasDbXref "Fyler:3816", "MSH:D012857", "SNOMEDCT_US:27317008", "SNOMEDCT_US:43876007", "UMLS:C0037221" ; oboInOwl:hasExactSynonym "Situs inversus visceralis", "Situs inversus viscerum" ; oboInOwl:id "HP:0003363" ; a owl:Class ; rdfs:label "Abdominal situs inversus" ; rdfs:subClassOf obo:HP_0011620 . obo:HP_0003365 obo:IAO_0000115 "Joint pain affecting the hip." ; oboInOwl:hasDbXref "SNOMEDCT_US:49218002", "UMLS:C0019559" ; oboInOwl:hasExactSynonym "Coxalgia", "Hip arthralgia", "Hip joint pain" ; oboInOwl:id "HP:0003365" ; a owl:Class ; rdfs:label "Arthralgia of the hip" ; rdfs:subClassOf obo:HP_0003272 . obo:HP_0003366 oboInOwl:hasDbXref "UMLS:C4025622" ; oboInOwl:hasExactSynonym "Abnormal neck or head of thigh bone", "Abnormality of the femoral neck or head region" ; oboInOwl:id "HP:0003366" ; a owl:Class ; rdfs:label "Abnormal femoral neck/head morphology" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0003367 obo:IAO_0000115 "An abnormality of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." ; oboInOwl:hasDbXref "UMLS:C4025621" ; oboInOwl:hasExactSynonym "Abnormal neck of thigh bone", "Abnormality of the femoral neck" ; oboInOwl:id "HP:0003367" ; a owl:Class ; rdfs:label "Abnormal femoral neck morphology" ; rdfs:subClassOf obo:HP_0003366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003368 obo:IAO_0000115 "An abnormality of the femoral head." ; oboInOwl:hasDbXref "UMLS:C4025620" ; oboInOwl:hasExactSynonym "Abnormal head of thigh bone", "Abnormality of the femoral head" ; oboInOwl:id "HP:0003368" ; a owl:Class ; rdfs:label "Abnormal femoral head morphology" ; rdfs:subClassOf obo:HP_0003366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003370 obo:IAO_0000115 "An abnormal flattening of the proximal epiphysis of the femur." ; oboInOwl:hasAlternativeId "HP:0006393" ; oboInOwl:hasDbXref "UMLS:C1842155" ; oboInOwl:hasExactSynonym "Flat capital femoral epiphyses", "Flat end part of innermost thighbone", "Flat femoral capital epiphyses", "Flat proximal femoral epiphyses", "Flattened proximal femoral epiphyses" ; oboInOwl:id "HP:0003370" ; a owl:Class ; rdfs:label "Flat capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0010574, obo:HP_0030289 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003371 obo:IAO_0000115 "An abnormal enlargement of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1859697" ; oboInOwl:hasExactSynonym "Enlarged capital femoral epiphyses", "Enlarged end part of innermost thighbone" ; oboInOwl:id "HP:0003371" ; a owl:Class ; rdfs:label "Enlargement of the proximal femoral epiphysis" ; rdfs:subClassOf obo:HP_0010574, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003375 obo:IAO_0000115 "A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." ; oboInOwl:hasAlternativeId "HP:0008803", "HP:0008805", "HP:0008813", "HP:0008840", "HP:0008842" ; oboInOwl:hasDbXref "SNOMEDCT_US:289457006", "UMLS:C0566888" ; oboInOwl:hasExactSynonym "Narrow greater sacrosciatic notches", "Narrow sacroiliac notch", "Narrow sacrosciatic notch", "Narrow sciatic notches", "Narrowed greater sciatic notch", "Narrowed sacrosciatic notch", "Small sacrosciatic notch", "Small sacrosciatic notches" ; oboInOwl:id "HP:0003375" ; a owl:Class ; rdfs:comment "The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a reduction in the lateral dimension of the notch." ; rdfs:label "Narrow greater sciatic notch" ; rdfs:subClassOf obo:HP_0010456 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003376 obo:IAO_0000115 "An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again." ; oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:27253007", "UMLS:C0427149" ; oboInOwl:hasExactSynonym "High stepping" ; oboInOwl:id "HP:0003376" ; a owl:Class ; rdfs:label "Steppage gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0003378 obo:IAO_0000115 "A pattern of simultaneous degeneration and regeneration of axons (see comment)." ; oboInOwl:hasDbXref "UMLS:C1968790" ; oboInOwl:hasExactSynonym "Axon degeneration and regeneration" ; oboInOwl:id "HP:0003378" ; a owl:Class ; rdfs:comment "This finding is typically demonstrated by nerve biopsy. Following focal damage to an axon, the part of the axon that is distal to the lesion invariably degenerates, a process that is known as anterograde (or Wallerian) degeneration. During Wallerian degeneration, often a microenvironment is created that can allow successful regrowth of nerve fibres from the proximal nerve segment." ; rdfs:label "Axonal degeneration/regeneration" ; rdfs:subClassOf obo:HP_0000764 . obo:HP_0003380 obo:IAO_0000115 "A loss of myelinated nerve fibers in the peripheral nervous system (in general, this finding can be observed on nerve biopsy)." ; oboInOwl:hasAlternativeId "HP:0003385", "HP:0003386", "HP:0007093", "HP:0007135", "HP:0007177", "HP:0007320", "HP:0007322" ; oboInOwl:hasDbXref "UMLS:C1858285" ; oboInOwl:hasExactSynonym "Decreased number of large and small myelinated fibers", "Decreased number of large and small myelinated fibres", "Decreased number of peripheral myelinated nerve fibres", "Loss of myelinated fibers", "Loss of myelinated fibres" ; oboInOwl:id "HP:0003380" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by nerve biopsy." ; rdfs:label "Decreased number of peripheral myelinated nerve fibers" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001021 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003382 oboInOwl:hasDbXref "UMLS:C1832776" ; oboInOwl:id "HP:0003382" ; a owl:Class ; rdfs:label "Hypertrophic nerve changes" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0003383 obo:IAO_0000115 "Repeated episodes of segmental demyelination and remyelination lead to the accumulation of supernumerary Schwann cells around axons, which is referred to as onion bulb formation. This finding affects peripheral nerves." ; oboInOwl:hasAlternativeId "HP:0003389", "HP:0007013", "HP:0007022", "HP:0007084", "HP:0008276" ; oboInOwl:hasDbXref "UMLS:C1847906" ; oboInOwl:hasRelatedSynonym "Onion bulb formations" ; oboInOwl:id "HP:0003383" ; a owl:Class ; rdfs:comment "This feature is characteristic of chronic demyelinating neuropathies as well as certain hereditary neuropathies. Onion-bulb formation may be observed in electron microscopic examinations of peripheral nerve biopsy material. Often, this examination is performed on the sural nerve." ; rdfs:label "Onion bulb formation" ; rdfs:subClassOf obo:HP_0003130 . obo:HP_0003384 obo:IAO_0000115 "Atrophic changes of axons of the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4025619" ; oboInOwl:id "HP:0003384" ; a owl:Class ; rdfs:comment "This finding is typically demonstrated by nerve biopsy." ; rdfs:label "Peripheral axonal atrophy" ; rdfs:subClassOf obo:HP_0000764 . obo:HP_0003387 obo:IAO_0000115 "A reduced number of large myelinated nerve fibers." ; oboInOwl:hasAlternativeId "HP:0006868", "HP:0007031", "HP:0007315" ; oboInOwl:hasDbXref "UMLS:C1859606" ; oboInOwl:hasExactSynonym "Decreased number of large peripheral myelinated nerve fibres", "Depletion of large myelinated fibers", "Depletion of large myelinated fibres", "Loss of large myelinated fibers", "Loss of large myelinated fibres", "Loss of larger myelinated nerve fibers", "Loss of larger myelinated nerve fibres" ; oboInOwl:id "HP:0003387" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by nerve biopsy." ; rdfs:label "Decreased number of large peripheral myelinated nerve fibers" ; rdfs:subClassOf obo:HP_0003380 . obo:HP_0003388 obo:IAO_0000115 "Increased susceptibility to fatigue." ; oboInOwl:hasBroadSynonym "Tired easily" ; oboInOwl:hasDbXref "SNOMEDCT_US:248268002", "UMLS:C0424585", "UMLS:C1837098" ; oboInOwl:id "HP:0003388" ; a owl:Class ; rdfs:comment "Fatigue describes the inability to continue performing a task after multiple repetitions." ; rdfs:label "Easy fatigability" ; rdfs:subClassOf obo:HP_0004302, obo:HP_0012638 . obo:HP_0003390 obo:IAO_0000115 "An axonal neuropathy of peripheral sensory nerves." ; oboInOwl:hasAlternativeId "HP:0006883", "HP:0007248", "HP:0007345" ; oboInOwl:hasDbXref "UMLS:C1842587", "UMLS:C1970883" ; oboInOwl:hasExactSynonym "Axonal sensory neuropathy" ; oboInOwl:hasRelatedSynonym "Peripheral sensory axonal neuropathy" ; oboInOwl:id "HP:0003390" ; a owl:Class ; rdfs:label "Sensory axonal neuropathy" ; rdfs:subClassOf obo:HP_0000763, obo:HP_0003477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030424 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001027 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003391 obo:IAO_0000115 "A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the proximal muscles of the lower limbs." ; oboInOwl:hasDbXref "SNOMEDCT_US:298294005", "SNOMEDCT_US:85905009", "UMLS:C0234182", "UMLS:C0575071" ; oboInOwl:hasExactSynonym "Gower sign", "Positive Gower sign", "Positive Gowers sign" ; oboInOwl:id "HP:0003391" ; a owl:Class ; rdfs:label "Gowers sign" ; rdfs:subClassOf obo:HP_0003701 . obo:HP_0003392 oboInOwl:hasDbXref "UMLS:C1832277" ; oboInOwl:id "HP:0003392" ; a owl:Class ; rdfs:label "First dorsal interossei muscle weakness" ; rdfs:subClassOf obo:HP_0002460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003393 obo:IAO_0000115 "Wasting of thenar muscles, which are located on palm of the hand at the base of the thumb." ; oboInOwl:hasDbXref "UMLS:C1864715" ; oboInOwl:hasExactSynonym "Thenar atrophy" ; oboInOwl:id "HP:0003393" ; a owl:Class ; rdfs:label "Thenar muscle atrophy" ; rdfs:subClassOf obo:HP_0009130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014376 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003394 obo:IAO_0000115 "Sudden and involuntary contractions of one or more muscles." ; oboInOwl:hasAlternativeId "HP:0009018", "HP:0031988" ; oboInOwl:hasDbXref "MSH:D009120", "SNOMEDCT_US:55300003", "UMLS:C0026821" ; oboInOwl:hasExactSynonym "Muscle cramps" ; oboInOwl:id "HP:0003394" ; a owl:Class ; rdfs:label "Muscle spasm" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0003396 obo:IAO_0000115 "Dilated, glial-lined cavity in spinal cord. This cavity does not communicate with the central canal, and usually is between the dorsal columns unilaterally or bilaterally along the side of the cord." ; oboInOwl:hasAlternativeId "HP:0006933" ; oboInOwl:hasDbXref "MSH:D013595", "SNOMEDCT_US:111496009", "UMLS:C0039144" ; oboInOwl:hasExactSynonym "Fluid-filled cyst in spinal cord", "Syrinx" ; oboInOwl:id "HP:0003396" ; a owl:Class ; rdfs:label "Syringomyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0003397 oboInOwl:hasDbXref "UMLS:C1853950" ; oboInOwl:hasExactSynonym "Generalised hypotonia due to defect at the neuromuscular junction" ; oboInOwl:id "HP:0003397" ; a owl:Class ; rdfs:label "Generalized hypotonia due to defect at the neuromuscular junction" ; rdfs:subClassOf obo:HP_0001290, obo:HP_0003398 . obo:HP_0003398 obo:IAO_0000115 "Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers." ; oboInOwl:hasDbXref "UMLS:C4020842", "UMLS:C4025618" ; oboInOwl:hasRelatedSynonym "Abnormality of neuromuscular transmission" ; oboInOwl:id "HP:0003398" ; a owl:Class ; rdfs:label "Abnormal synaptic transmission at the neuromuscular junction" ; rdfs:subClassOf obo:HP_0030191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0031594 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003400 obo:IAO_0000115 "A type of onion bulb formation prominently affecting the area of the basal lamina." ; oboInOwl:hasDbXref "UMLS:C1866637" ; oboInOwl:hasExactSynonym "Basal lamina 'onion bulb' formations on nerve biopsy" ; oboInOwl:id "HP:0003400" ; a owl:Class ; rdfs:label "Basal lamina onion bulb formation" ; rdfs:subClassOf obo:HP_0003383 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003383 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003401 obo:IAO_0000115 "Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause." ; oboInOwl:hasAlternativeId "HP:0002082" ; oboInOwl:hasDbXref "MSH:D010292", "SNOMEDCT_US:91019004", "UMLS:C0030554" ; oboInOwl:hasExactSynonym "Paresthesias", "Pins and needles feeling", "Tingling" ; oboInOwl:id "HP:0003401" ; a owl:Class ; rdfs:label "Paresthesia" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0003402 obo:IAO_0000115 "An abnormal reduction in the amplitude of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction." ; oboInOwl:hasDbXref "UMLS:C1853952" ; oboInOwl:hasExactSynonym "Decreased MEPP", "Small miniature endplate currents", "Small miniature endplate potentials" ; oboInOwl:id "HP:0003402" ; a owl:Class ; rdfs:comment "Miniature end plate potentials are the small (about 0.5mV) depolarisations of the postsynaptic terminal caused by the release of a single vesicle into the synaptic cleft." ; rdfs:label "Decreased miniature endplate potentials" ; rdfs:subClassOf obo:HP_0003398 . obo:HP_0003403 obo:IAO_0000115 "A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to a greater than normal decrease in the amplitude during the course of the investigation." ; oboInOwl:hasAlternativeId "HP:0003430", "HP:0003478" ; oboInOwl:hasDbXref "UMLS:C4020841", "UMLS:C4021728" ; oboInOwl:hasExactSynonym "EMG: decremental response of CMAP to repetitive nerve stimulation" ; oboInOwl:hasRelatedSynonym "EMG: decrement at repetitive stimulation" ; oboInOwl:id "HP:0003403" ; a owl:Class ; rdfs:comment "The result of this test is abnormal if progressively fewer muscle fibers respond to nerve stimulation during a train of stimuli, thereby yielding a decrementing pattern in the CMAP." ; rdfs:label "EMG: decremental response of compound muscle action potential to repetitive nerve stimulation" ; rdfs:subClassOf obo:HP_0100285 . obo:HP_0003405 oboInOwl:hasDbXref "UMLS:C1865417" ; oboInOwl:id "HP:0003405" ; a owl:Class ; rdfs:label "Diffuse axonal swelling" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0003406 oboInOwl:hasDbXref "UMLS:C1851414" ; oboInOwl:id "HP:0003406" ; a owl:Class ; rdfs:label "Peripheral nerve compression" ; rdfs:subClassOf obo:HP_0000759 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001021 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003409 obo:IAO_0000115 "Reduced ability to sense pain, temperature, touch, vibration stimuli in the distal regions of the extremities." ; oboInOwl:hasAlternativeId "HP:0006984" ; oboInOwl:hasDbXref "UMLS:C1836527" ; oboInOwl:hasExactSynonym "Distal sensory loss to all modalities" ; oboInOwl:id "HP:0003409" ; a owl:Class ; rdfs:label "Distal sensory impairment of all modalities" ; rdfs:subClassOf obo:HP_0000763 . obo:HP_0003411 obo:IAO_0000115 "Irregularity of the normally smooth surface of the proximal metaphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1836320" ; oboInOwl:hasExactSynonym "Irregular proximal femoral metaphyses" ; oboInOwl:id "HP:0003411" ; a owl:Class ; rdfs:label "Proximal femoral metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003366, obo:HP_0006431, obo:HP_0030291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003413 obo:IAO_0000115 "An anomaly of the atlantoaxial joint, i.e., of the joint between the first (atlas) and second (axis) cervical vertebrae." ; oboInOwl:hasDbXref "UMLS:C4025617" ; oboInOwl:id "HP:0003413" ; a owl:Class ; rdfs:label "Atlantoaxial abnormality" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003694 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003414 obo:IAO_0000115 "Partial dislocation of the atlantoaxial joint." ; oboInOwl:hasDbXref "SNOMEDCT_US:263042007", "SNOMEDCT_US:45179004", "UMLS:C0263905" ; oboInOwl:hasExactSynonym "Atlanto-axial subluxation", "Atlantoaxial subluxation" ; oboInOwl:id "HP:0003414" ; a owl:Class ; rdfs:label "Atlantoaxial dislocation" ; rdfs:subClassOf obo:HP_0003413 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003694 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003416 obo:IAO_0000115 "An abnormal narrowing of the spinal canal." ; oboInOwl:hasAlternativeId "HP:0008446" ; oboInOwl:hasDbXref "UMLS:C1861329" ; oboInOwl:hasExactSynonym "Narrow spinal canal", "Spinal stenosis" ; oboInOwl:id "HP:0003416" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Stenosis of the spinal canal can result in neurological symptoms because of compression of the spinal cord or spinal nerve roots, depending on the location of the stenosis in the vertebral column." ; rdfs:label "Spinal canal stenosis" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002291 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003417 obo:IAO_0000115 "Frontal schisis (cleft or cleavage) of vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0003673" ; oboInOwl:hasDbXref "UMLS:C1834954" ; oboInOwl:hasExactSynonym "Coronal clefts", "Coronal vertebral clefts", "Vertebral coronal clefts", "coronal cleft of vertebrae" ; oboInOwl:id "HP:0003417" ; a owl:Class ; rdfs:comment "Coronal cleft vertebrae result when there are two, instead of one, primary ossification centers in a vertebral body. An unossified cartilaginous brdige may be observed radiographically with the shape of a cleft. If the two ossification centers are ventral/dorsal, a coronal cleft is observed, and if the two ossification centers are left/right, than a sagittal cleft is observed." ; rdfs:label "Coronal cleft vertebrae" ; rdfs:subClassOf obo:HP_0008428 . obo:HP_0003418 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back." ; oboInOwl:hasDbXref "MSH:D001416", "SNOMEDCT_US:161891005", "UMLS:C0004604" ; oboInOwl:hasExactSynonym "Back pain" ; oboInOwl:id "HP:0003418" ; a owl:Class ; rdfs:label "Back pain" ; rdfs:subClassOf obo:HP_0000925, obo:HP_0012531 . obo:HP_0003419 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back." ; oboInOwl:hasDbXref "MSH:D017116", "SNOMEDCT_US:279039007", "UMLS:C0024031" ; oboInOwl:hasExactSynonym "Lower back pain", "Lumbago" ; oboInOwl:id "HP:0003419" ; a owl:Class ; rdfs:label "Low back pain" ; rdfs:subClassOf obo:HP_0003418 . obo:HP_0003421 obo:IAO_0100001 "HP:0000926" ; oboInOwl:id "HP:0003421" ; a owl:Class ; rdfs:label "obsolete Platyspondyly (childhood)" ; owl:deprecated true . obo:HP_0003422 obo:IAO_0000115 "An abnormality related to a defect of vertebral separation during development." ; oboInOwl:hasAlternativeId "HP:0005705" ; oboInOwl:hasDbXref "SNOMEDCT_US:205455005", "UMLS:C0432163" ; oboInOwl:hasExactSynonym "Abnormal spinal segmentation" ; oboInOwl:id "HP:0003422" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The vertebral column derives from somites, transient paired segments of mesoderm that surround the neural tube in the early embryo. The formation of the vertebrar involves many processes including resegmentation of the rostral and caudal regions of adjacent somites that then fuse to form vertebral elements. Disruption of these processes can a cause of severe segmentation defects of the vetebrae. The frequency of segmentation defects of the vetebra has been estimated at 0.5 of 1000 births. The range of segmentation defects includes left-right uneven formation of somites that results in hemivertebrae or wedge vertebrae. Incomplete segmentation can result in fused segments such as block vertebrae. A failure of the process of resegmentation and migration of the sclerotomal compartment can result in a failure of midline fusion, such as butterlfy vertebrae." ; rdfs:label "Vertebral segmentation defect" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0003423 oboInOwl:hasDbXref "UMLS:C1859335" ; oboInOwl:hasExactSynonym "Dorsolumbar kyphosis" ; oboInOwl:id "HP:0003423" ; a owl:Class ; rdfs:label "Thoracolumbar kyphoscoliosis" ; rdfs:subClassOf obo:HP_0002751, obo:HP_0002944, obo:HP_0005619 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002751 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009568 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003426 oboInOwl:hasDbXref "UMLS:C1832278" ; oboInOwl:id "HP:0003426" ; a owl:Class ; rdfs:label "First dorsal interossei muscle atrophy" ; rdfs:subClassOf obo:HP_0007181 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003427 oboInOwl:hasDbXref "UMLS:C1832276" ; oboInOwl:id "HP:0003427" ; a owl:Class ; rdfs:label "Thenar muscle weakness" ; rdfs:subClassOf obo:HP_0030237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014376 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003429 obo:IAO_0000115 "Reduced amount of myelin in the central nervous system resulting from defective myelinogenesis." ; oboInOwl:hasDbXref "SNOMEDCT_US:111007000", "UMLS:C0544820", "UMLS:C4025616" ; oboInOwl:id "HP:0003429" ; a owl:Class ; rdfs:label "CNS hypomyelination" ; rdfs:subClassOf obo:HP_0011400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000345 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003431 obo:IAO_0000115 "A type of decreased nerve conduction velocity that affects the motor neuron." ; oboInOwl:hasAlternativeId "HP:0000760", "HP:0003379", "HP:0003395", "HP:0003437", "HP:0006907", "HP:0008170" ; oboInOwl:hasDbXref "UMLS:C1858729" ; oboInOwl:hasExactSynonym "Decreased motor NCV", "Decreased motor nerve conduction velocities", "Reduced motor nerve conduction velocity" ; oboInOwl:id "HP:0003431" ; a owl:Class ; rdfs:comment "Newborn infants have values that are approximately half that of adults, and adult values are normally reached by age 3 or 4. Motor nerve conduction is evaluated by recording the compound muscle action potential (CMAP) associated with a mechanical contraction of a given muscle in response to electrical stimulation of the motor nerve fibers supplying that muscle. The CMAP is the sum of all the action potentials occurring individually in the contracting muscle fibers." ; rdfs:label "Decreased motor nerve conduction velocity" ; rdfs:subClassOf obo:HP_0000762, obo:HP_0040131 . obo:HP_0003434 oboInOwl:hasDbXref "UMLS:C1843859" ; oboInOwl:id "HP:0003434" ; a owl:Class ; rdfs:label "Sensory ataxic neuropathy" ; rdfs:subClassOf obo:HP_0000763 . obo:HP_0003435 oboInOwl:hasDbXref "UMLS:C1832279" ; oboInOwl:id "HP:0003435" ; a owl:Class ; rdfs:label "Cold-induced hand cramps" ; rdfs:subClassOf obo:HP_0003449 . obo:HP_0003436 obo:IAO_0000115 "An abnormal prolongation of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction." ; oboInOwl:hasAlternativeId "HP:0003479" ; oboInOwl:hasDbXref "UMLS:C1864238" ; oboInOwl:hasExactSynonym "Prolonged MEPC", "Prolonged MEPP", "Prolonged miniature endplate potentials" ; oboInOwl:id "HP:0003436" ; a owl:Class ; rdfs:label "Prolonged miniature endplate currents" ; rdfs:subClassOf obo:HP_0003398 . obo:HP_0003438 obo:IAO_0000115 "Absence of the Achilles reflex (also known as the ankle jerk reflex), which can normally be elicited by tapping the tendon is tapped while the foot is dorsiflexed." ; oboInOwl:hasAlternativeId "HP:0007032", "HP:0007241" ; oboInOwl:hasDbXref "MSH:D012021", "SNOMEDCT_US:274818004", "UMLS:C0558845" ; oboInOwl:hasExactSynonym "Absent ankle reflexes" ; oboInOwl:id "HP:0003438" ; a owl:Class ; rdfs:label "Absent Achilles reflex" ; rdfs:subClassOf obo:HP_0200101 . obo:HP_0003440 oboInOwl:hasDbXref "UMLS:C1850558" ; oboInOwl:id "HP:0003440" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Horizontal sacrum" ; rdfs:subClassOf obo:HP_0005107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001855 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003443 obo:IAO_0000115 "A reduction in the size of nerve terminals." ; oboInOwl:hasDbXref "UMLS:C4025615" ; oboInOwl:id "HP:0003443" ; a owl:Class ; rdfs:comment "Nerve terminals are the output region of nerves located presynaptically and (in the case of chemical synapses) containing vesicles of chemical neurotransmitters. Presynaptic nerve terminals normally are larger in diameter than the axon and have the appearance of a bud. This feature can be demonstrated by muscle biopsy." ; rdfs:label "Decreased size of nerve terminals" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0003444 obo:IAO_0000115 "Evidence of chronic denervation on electromyography." ; oboInOwl:hasAlternativeId "HP:0007059" ; oboInOwl:hasDbXref "UMLS:C4025614" ; oboInOwl:id "HP:0003444" ; a owl:Class ; rdfs:comment "This is a bundled term that is kept for convenience. It is preferable to annotate the precise clinical abnormalities observed." ; rdfs:label "EMG: chronic denervation signs" ; rdfs:subClassOf obo:HP_0003445 . obo:HP_0003445 obo:IAO_0000115 "The presence of characteristic findings of denervation on electromyography (fibrillations, positive sharp waves, and giant motor unit potentials)." ; oboInOwl:hasAlternativeId "HP:0002178", "HP:0002547", "HP:0007279" ; oboInOwl:hasDbXref "UMLS:C4021727" ; oboInOwl:hasExactSynonym "EMG: neurogenic abnormalities", "EMG: neurogenic changes", "EMG: neurogenic findings" ; oboInOwl:id "HP:0003445" ; a owl:Class ; rdfs:comment "This is a bundled term. It is preferable to annotate the precise clinical observations, but the term is kept now for convenience." ; rdfs:label "EMG: neuropathic changes" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0003447 obo:IAO_0000115 "A reduction in the number of axons in the peripheral nervous system." ; oboInOwl:hasAlternativeId "HP:0003360" ; oboInOwl:hasDbXref "UMLS:C1832338" ; oboInOwl:id "HP:0003447" ; a owl:Class ; rdfs:comment "This finding can be observed upon nerve biopsy." ; rdfs:label "Axonal loss" ; rdfs:subClassOf obo:HP_0000764 . obo:HP_0003448 obo:IAO_0000115 "Reduced speed of conduction of the action potential along a sensory nerve." ; oboInOwl:hasAlternativeId "HP:0006914" ; oboInOwl:hasDbXref "UMLS:C1849148" ; oboInOwl:hasExactSynonym "Decreased sensory NCV", "Decreased sensory nerve conduction velocities" ; oboInOwl:id "HP:0003448" ; a owl:Class ; rdfs:comment "The sensory nerve action potential (SNAP) in response to electrical stimulation is recorded from the nerve itself by means of dermal recording electrodes. The SNAP is the sum of all the action potentials generated in sensory nerve fibres by the applied electrical impulse." ; rdfs:label "Decreased sensory nerve conduction velocity" ; rdfs:subClassOf obo:HP_0000762, obo:HP_0040132 . obo:HP_0003449 obo:IAO_0000115 "Sudden and involuntary contractions of one or more muscles brought on by exposure to cold temperatures." ; oboInOwl:hasDbXref "UMLS:C1861675" ; oboInOwl:id "HP:0003449" ; a owl:Class ; rdfs:label "Cold-induced muscle cramps" ; rdfs:subClassOf obo:HP_0003394 . obo:HP_0003450 obo:IAO_0000115 "The presence of axonal regeneration following a previous axonal lesion." ; oboInOwl:hasDbXref "UMLS:C1854454" ; oboInOwl:hasExactSynonym "Regenerative activity on nerve biopsy" ; oboInOwl:id "HP:0003450" ; a owl:Class ; rdfs:comment "This finding is typically demonstrated by nerve biopsy. See the comment of term HP:0003378 for further information." ; rdfs:label "Axonal regeneration" ; rdfs:subClassOf obo:HP_0000764 . obo:HP_0003451 obo:IAO_0000115 "An increased rate of premature chromosome condensation." ; oboInOwl:hasDbXref "UMLS:C4025613" ; oboInOwl:id "HP:0003451" ; a owl:Class ; rdfs:label "Increased rate of premature chromosome condensation" ; rdfs:subClassOf obo:HP_0011019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030261 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003452 oboInOwl:hasDbXref "SNOMEDCT_US:165624002", "UMLS:C0151900" ; oboInOwl:id "HP:0003452" ; a owl:Class ; rdfs:label "Increased serum iron" ; rdfs:subClassOf obo:HP_0040130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003453 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against neutrophils." ; oboInOwl:hasDbXref "UMLS:C1858981" ; oboInOwl:hasExactSynonym "Antineutrophil antibodies", "Neutrophil antibody positive" ; oboInOwl:id "HP:0003453" ; a owl:Class ; rdfs:comment "Circulating serum antibodies are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as weakly positive and greater than 3 standard deviations as positive." ; rdfs:label "Antineutrophil antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0003454 obo:IAO_0000115 "The presence in the serum of autoantibodies directed against thrombocytes." ; oboInOwl:hasDbXref "UMLS:C1858980" ; oboInOwl:hasExactSynonym "Platelet antibody" ; oboInOwl:id "HP:0003454" ; a owl:Class ; rdfs:label "Platelet antibody positive" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0003455 obo:IAO_0000115 "Increased concentration of long-chain fatty acids in the blood circulation." ; oboInOwl:hasAlternativeId "HP:0008333", "HP:0045016" ; oboInOwl:hasDbXref "UMLS:C1859241" ; oboInOwl:hasExactSynonym "Elevated long chain fatty acids", "Elevated serum long-chain fatty acids", "Increased serum long-chain fatty acids" ; oboInOwl:id "HP:0003455" ; a owl:Class ; rdfs:comment "This feature can be measured in plasma, as well as in cultured fibroblasts of amniocytes." ; rdfs:label "Elevated circulating long chain fatty acid concentration" ; rdfs:subClassOf obo:HP_0010964 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15904 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003456 oboInOwl:hasDbXref "UMLS:C1864105" ; oboInOwl:id "HP:0003456" ; a owl:Class ; rdfs:label "Low urinary cyclic AMP response to PTH administration" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0003457 obo:IAO_0000115 "Abnormal results of investigations using electromyography (EMG)." ; oboInOwl:hasAlternativeId "HP:0002177", "HP:0003751", "HP:0003753", "HP:0100286" ; oboInOwl:hasDbXref "SNOMEDCT_US:274523007", "UMLS:C0476403" ; oboInOwl:hasExactSynonym "Abnormal EMG", "Abnormal electromyography finding", "EMG abnormalities", "Electromyogram abnormal" ; oboInOwl:id "HP:0003457" ; a owl:Class ; rdfs:label "EMG abnormality" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0003458 obo:IAO_0000115 "The presence of abnormal electromyographic patterns indicative of myopathy, such as small-short polyphasic motor unit potentials." ; oboInOwl:hasAlternativeId "HP:0003322", "HP:0003711", "HP:0009021" ; oboInOwl:hasDbXref "UMLS:C4021726" ; oboInOwl:hasExactSynonym "EMG: myopathic changes", "EMG: myopathy", "Myopathic electromyogram" ; oboInOwl:id "HP:0003458" ; a owl:Class ; rdfs:label "EMG: myopathic abnormalities" ; rdfs:subClassOf obo:HP_0003198, obo:HP_0003457 . obo:HP_0003459 obo:IAO_0000115 "A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis." ; oboInOwl:hasDbXref "UMLS:C4025612" ; oboInOwl:id "HP:0003459" ; a owl:Class ; rdfs:label "Polyclonal elevation of IgM" ; rdfs:subClassOf obo:HP_0003496 . obo:HP_0003460 obo:IAO_0000115 "Undetectable serum immunoglobulin A level at a value < 5 mg/dL (0.05 g/L)." ; oboInOwl:hasDbXref "UMLS:C4025611" ; oboInOwl:hasExactSynonym "Decreased total IgA in blood", "Total immunoglobulin A deficiency" ; oboInOwl:id "HP:0003460" ; a owl:Class ; rdfs:label "Decreased circulating total IgA" ; rdfs:subClassOf obo:HP_0002720 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003461 obo:IAO_0000115 "Excretion of peptides conjugated to sialic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C1836533" ; oboInOwl:id "HP:0003461" ; a owl:Class ; rdfs:label "Increased urinary O-linked sialopeptides" ; rdfs:subClassOf obo:HP_0012067 . obo:HP_0003462 oboInOwl:hasDbXref "UMLS:C1840013" ; oboInOwl:id "HP:0003462" ; a owl:Class ; rdfs:label "Elevated 8-dehydrocholesterol" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0003463 obo:IAO_0000115 "Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the extraneuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." ; oboInOwl:hasDbXref "UMLS:C1859828" ; oboInOwl:hasRelatedSynonym "Lipopigment in extraneuronal cells" ; oboInOwl:id "HP:0003463" ; a owl:Class ; rdfs:label "Increased extraneuronal autofluorescent lipopigment" ; rdfs:subClassOf obo:HP_0011813 . obo:HP_0003464 obo:IAO_0100001 "HP:0003107" ; oboInOwl:id "HP:0003464" ; a owl:Class ; rdfs:label "obsolete Abnormal cholesterol homeostasis" ; owl:deprecated true . obo:HP_0003465 oboInOwl:hasDbXref "UMLS:C1840014" ; oboInOwl:id "HP:0003465" ; a owl:Class ; rdfs:label "Elevated 8(9)-cholestenol" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0003466 oboInOwl:hasDbXref "UMLS:C1968855" ; oboInOwl:id "HP:0003466" ; a owl:Class ; rdfs:label "Paradoxical increased cortisol secretion on dexamethasone suppression test" ; rdfs:subClassOf obo:HP_0011731 . obo:HP_0003467 obo:IAO_0000115 "Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly." ; oboInOwl:hasDbXref "SNOMEDCT_US:202820009", "UMLS:C0410653" ; oboInOwl:id "HP:0003467" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Neurological deficits ensue if the odontoid process, or posterior arch of the atlas, impinges on the spinal cord." ; rdfs:label "Atlantoaxial instability" ; rdfs:subClassOf obo:HP_0003413 . obo:HP_0003468 obo:IAO_0000115 "An abnormality of one or more of the vertebrae." ; oboInOwl:hasAlternativeId "HP:0005719" ; oboInOwl:hasDbXref "Fyler:4108", "SNOMEDCT_US:205043005", "SNOMEDCT_US:74877002", "UMLS:C0158775", "UMLS:C4020839", "UMLS:C4020840" ; oboInOwl:hasExactSynonym "Abnormal vertebrae", "Abnormality of the vertebrae", "Vertebral anomalies" ; oboInOwl:hasRelatedSynonym "Abnormal vertebral bodies", "Multiple vertebral anomalies" ; oboInOwl:id "HP:0003468" ; a owl:Class ; rdfs:comment "A vertebra is one of 33 bony segments that form the spinal column of humans. There are 7 cervical, 12 thoracic, 5 lumbar, 5 sacral and 4 coccygeal vertebrae (the coccygeal vertebrae are fused into one coccyx bone)." ; rdfs:label "Abnormal vertebral morphology" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003469 obo:IAO_0000115 "Defective structure and function of myelin sheaths. Dysmyelination is distinguished from demyleination where there is destruction or damage of previously normal myelination." ; oboInOwl:hasDbXref "UMLS:C4025610" ; oboInOwl:id "HP:0003469" ; a owl:Class ; rdfs:label "Peripheral dysmyelination" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042552 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003470 obo:IAO_0000115 "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement." ; oboInOwl:hasDbXref "MSH:D010243", "SNOMEDCT_US:44695005", "UMLS:C0522224" ; oboInOwl:hasExactSynonym "Inability to move", "Paralysis" ; oboInOwl:id "HP:0003470" ; a owl:Class ; rdfs:label "Paralysis" ; rdfs:subClassOf obo:HP_0011442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003472 obo:IAO_0000115 "Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms." ; oboInOwl:hasDbXref "SNOMEDCT_US:190869004", "UMLS:C0151940" ; oboInOwl:id "HP:0003472" ; a owl:Class ; rdfs:label "Hypocalcemic tetany" ; rdfs:subClassOf obo:HP_0002901, obo:HP_0012638 . obo:HP_0003473 obo:IAO_0000115 "A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasAlternativeId "HP:0003399", "HP:0003428", "HP:0100794" ; oboInOwl:hasDbXref "UMLS:C0947912" ; oboInOwl:hasExactSynonym "Fatigable weakness of limb muscles", "Generalised muscle weakness due to defect at the neuromuscular junction", "Generalized muscle weakness due to defect at the neuromuscular junction", "Myasthenia", "Myasthenic weakness", "Proximal muscle weakness due to defect at the neuromuscular junction" ; oboInOwl:id "HP:0003473" ; a owl:Class ; rdfs:comment "This type of weakness is pathognomonic for an abnormality of the neuromuscular junction such as myasthenia gravis. A characteristic form of muscular weakness that worsens after use of affected muscles. Myasthenia is caused by failure of neuromuscular transmission, which results from the binding of autoantibodies to proteins involved in signaling at the neuromuscular junction, including especially the nicotinic acetyl choline receptor (AChR) or, less frequently, a muscle-specific tyrosine kinase involved in AChR clustering." ; rdfs:label "Fatigable weakness" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0003398 . obo:HP_0003474 obo:IAO_0000115 "An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing." ; oboInOwl:hasAlternativeId "HP:0100964" ; oboInOwl:hasDbXref "MSH:D006987", "SNOMEDCT_US:397974008", "SNOMEDCT_US:398026008", "SNOMEDCT_US:59073000", "UMLS:C0020580" ; oboInOwl:hasExactSynonym "Sensory impairment" ; oboInOwl:id "HP:0003474" ; a owl:Class ; rdfs:comment "This term does not include abnormalities of cortical sensation such as two-point discrimination, stereognosis, and graphesthesia." ; rdfs:label "Somatic sensory dysfunction" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0003477 obo:IAO_0000115 "An abnormality characterized by disruption of the normal functioning of peripheral axons." ; oboInOwl:hasAlternativeId "HP:0006814", "HP:0006842", "HP:0007169", "HP:0008304" ; oboInOwl:hasDbXref "SNOMEDCT_US:128208007", "SNOMEDCT_US:60703000", "UMLS:C0270921", "UMLS:C1263857" ; oboInOwl:hasExactSynonym "Axonal neuropathy", "Axonal peripheral neuropathy" ; oboInOwl:id "HP:0003477" ; a owl:Class ; rdfs:comment "This abnormality can be assay by electromyography (EMG) or by nerve biopsy." ; rdfs:label "Peripheral axonal neuropathy" ; rdfs:subClassOf obo:HP_0000764, obo:HP_0009830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009830 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003481 obo:IAO_0000115 "A segmental pattern of demyelination and regeneration (remyelination) affecting peripheral nerves." ; oboInOwl:hasAlternativeId "HP:0003425" ; oboInOwl:hasDbXref "UMLS:C1843077" ; oboInOwl:hasExactSynonym "Segmental demyelination/remyelination" ; oboInOwl:id "HP:0003481" ; a owl:Class ; rdfs:label "Segmental peripheral demyelination/remyelination" ; rdfs:subClassOf obo:HP_0011096 . obo:HP_0003482 obo:IAO_0000115 "Electromyographic (EMG) findings characteristic of axonal neuropathy, with normal or slightly decreased nerve conduction velocities, normal or slightly prolonged distal latencies, but significantly reduced motor potentials and sensory amplitudes. There may be spontaneous activity upon needle EMG studies, such as increased insertional activity, positive sharp waves, and fibrillation potentials." ; oboInOwl:hasDbXref "UMLS:C4025609" ; oboInOwl:id "HP:0003482" ; a owl:Class ; rdfs:comment "This is a bundled term that is kept for convenience. It is preferable to record the precise clinical observations." ; rdfs:label "EMG: axonal abnormality" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0003484 obo:IAO_0000115 "Weakness of the muscles of the arms." ; oboInOwl:hasDbXref "SNOMEDCT_US:713512009", "UMLS:C1698196" ; oboInOwl:hasExactSynonym "Decreased arm strength", "Weak arm" ; oboInOwl:id "HP:0003484" ; a owl:Class ; rdfs:label "Upper limb muscle weakness" ; rdfs:subClassOf obo:HP_0003690 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003487 obo:IAO_0000115 "Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract." ; oboInOwl:hasAlternativeId "HP:0001352" ; oboInOwl:hasDbXref "SNOMEDCT_US:246586009", "SNOMEDCT_US:366575004", "UMLS:C0034935" ; oboInOwl:hasExactSynonym "Extensor plantar reflexes", "Extensor plantar response", "Extensor plantar responses", "Positive Babinski sign" ; oboInOwl:id "HP:0003487" ; a owl:Class ; rdfs:comment "A positive Babinski sign can indicate damage to the corticospinal tract." ; rdfs:label "Babinski sign" ; rdfs:subClassOf obo:HP_0007256, obo:HP_0031828 . obo:HP_0003489 oboInOwl:hasDbXref "UMLS:C1867971" ; oboInOwl:id "HP:0003489" ; a owl:Class ; rdfs:comment "Neuropathic symptoms include numbness, dysesthesias, and a characteristic form of pain (neuralgia)." ; rdfs:label "Acute episodes of neuropathic symptoms" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0003490 obo:IAO_0100001 "HP:0003150" ; oboInOwl:id "HP:0003490" ; a owl:Class ; rdfs:label "obsolete Defective dehydrogenation of isovaleryl CoA and butyryl CoA" ; owl:deprecated true . obo:HP_0003491 obo:IAO_0000115 "An abnormally increased diphosphate(4-) concentration in the urine. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate." ; oboInOwl:hasDbXref "UMLS:C4025607" ; oboInOwl:id "HP:0003491" ; a owl:Class ; rdfs:label "Elevated urine pyrophosphate" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003492 obo:IAO_0000115 "An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism." ; oboInOwl:hasDbXref "UMLS:C4025606" ; oboInOwl:id "HP:0003492" ; a owl:Class ; rdfs:comment """'has part' some ('increased amount' and ('inheres in' some ('Gonadotropin (adult human)' and ('part of' some urine))) and ('has modifier' some abnormal))""" ; rdfs:label "High urinary gonadotropin level" ; rdfs:subClassOf obo:HP_0012029 . obo:HP_0003493 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against nuclei or nuclear components." ; oboInOwl:hasDbXref "SNOMEDCT_US:165850001", "UMLS:C0151480" ; oboInOwl:hasExactSynonym "Antinuclear antibodies", "Antinuclear antibody positive", "Elevated antinuclear antibody", "Serum antinuclear antibody" ; oboInOwl:id "HP:0003493" ; a owl:Class ; rdfs:comment "Antinuclear antibodies (ANAs) are found in patients with a number of different autoimmune diseases, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, polymyositis, scleroderma, Hashimoto's thyroiditis, juvenile diabetes mellitus, Addison disease, vitiligo, pernicious anemia, glomerulonephritis, and pulmonary fibrosis. ANAs can display various staining patterns such as homogeneous or diffuse; speckled; nucleolar; and peripheral or rim." ; rdfs:label "Antinuclear antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0003494 oboInOwl:consider "HP:0000005" ; oboInOwl:id "HP:0003494" ; a owl:Class ; rdfs:label "obsolete Loss of heterozygosity, multiple chromosomes" ; owl:deprecated true . obo:HP_0003495 obo:IAO_0000115 "Cellular accumulation of GM2 gangliosides." ; oboInOwl:hasDbXref "UMLS:C1848920" ; oboInOwl:id "HP:0003495" ; a owl:Class ; rdfs:comment "Gangliosides are the main glycolipids of neuronal cell plasma membranes which ensure normal cellular activities. GM2-gangliosidosis can be caused by mutations in three genes: HEXA, HEXB, and GM2A. In patients with HexA deficiency GM2 ganglioside accumulates inside lysosomes, which form characteristic inclusions within the cells, so called membranous cytoplasmic bodies, which are enlarged lysosomes filled with gangliosides. The highest concentration of GM2 ganglioside is found in neuronal cells, therefore, the HexA deficiency primarily affects the nervous system, causing mental and motor developmental delay in patients. Later, progressive destruction of neurons, proliferation of microglia and accumulation of complex lipids in macrophages are observed in the brain tissue." ; rdfs:label "GM2-ganglioside accumulation" ; rdfs:subClassOf obo:HP_0004345 . obo:HP_0003496 obo:IAO_0000115 "An abnormally increased level of immunoglobulin M in blood." ; oboInOwl:hasAlternativeId "HP:0002962" ; oboInOwl:hasDbXref "UMLS:C1839972" ; oboInOwl:hasExactSynonym "Increased IgM levels", "Increased levels of IgM" ; oboInOwl:id "HP:0003496" ; a owl:Class ; rdfs:label "Increased circulating IgM level" ; rdfs:subClassOf obo:HP_0010702, obo:HP_0410243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003498 obo:IAO_0000115 "A kind of short stature in which different regions of the body are shortened to differing extents." ; oboInOwl:hasAlternativeId "HP:0008895", "HP:0008900" ; oboInOwl:hasDbXref "UMLS:C0878659", "UMLS:C1846797" ; oboInOwl:hasExactSynonym "Short stature, disproportionate" ; oboInOwl:hasRelatedSynonym "Short stature, severe disproportionate" ; oboInOwl:id "HP:0003498" ; a owl:Class ; rdfs:label "Disproportionate short stature" ; rdfs:subClassOf obo:HP_0004322 . obo:HP_0003502 obo:IAO_0000115 "A mild degree of short stature, more than -2 SD but not more than -3 SD from mean corrected for age and sex." ; oboInOwl:hasAlternativeId "HP:0003503", "HP:0008879", "HP:0008908" ; oboInOwl:hasDbXref "UMLS:C3150077", "UMLS:C4020838" ; oboInOwl:hasExactSynonym "short stature, mild" ; oboInOwl:hasRelatedSynonym "Relative short stature" ; oboInOwl:id "HP:0003502" ; a owl:Class ; rdfs:label "Mild short stature" ; rdfs:subClassOf obo:HP_0003508 . obo:HP_0003508 obo:IAO_0000115 "A kind of short stature in which different regions of the body are shortened to a comparable extent." ; oboInOwl:hasAlternativeId "HP:0003499" ; oboInOwl:hasDbXref "UMLS:C0878660" ; oboInOwl:hasExactSynonym "Proportionate small stature", "Short stature, proportionate" ; oboInOwl:id "HP:0003508" ; a owl:Class ; rdfs:label "Proportionate short stature" ; rdfs:subClassOf obo:HP_0004322 . obo:HP_0003510 obo:IAO_0000115 "A severe degree of short stature, more than -4 SD from the mean corrected for age and sex." ; oboInOwl:hasAlternativeId "HP:0001424", "HP:0001516", "HP:0003504", "HP:0008867", "HP:0008884", "HP:0008907", "HP:0008920", "HP:0008930" ; oboInOwl:hasDbXref "MSH:D004392", "SNOMEDCT_US:237836003", "SNOMEDCT_US:237837007", "SNOMEDCT_US:422065006", "UMLS:C0013336" ; oboInOwl:hasExactSynonym "Dwarfism", "Proportionate dwarfism", "Severe short stature", "Short stature, extreme", "Short stature, severe" ; oboInOwl:id "HP:0003510" ; a owl:Class ; rdfs:comment "The term severe short stature is to be preferred over dwarfism, which has been used in the past to refer to individuals with an adult height under 4 feet 10 inches (147 cm)." ; rdfs:label "Severe short stature" ; rdfs:subClassOf obo:HP_0003508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000969 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003513 obo:IAO_0000115 "A reduction of the ratio of renal calcium clearance to creatinine clearance to below 0.01." ; oboInOwl:hasDbXref "UMLS:C4025605" ; oboInOwl:hasExactSynonym "Reduced ration of kidney calcium clearance to creatinine clearance", "Reduced ration of renal Ca clearance to creatinine clearance", "Reduced ration of renal Ca2+ to creatinine clearance" ; oboInOwl:id "HP:0003513" ; a owl:Class ; rdfs:label "Reduced ratio of renal calcium clearance to creatinine clearance" ; rdfs:subClassOf obo:HP_0011280 . obo:HP_0003514 oboInOwl:hasDbXref "UMLS:C1844390" ; oboInOwl:hasExactSynonym "Deficiency or absence of cytochrome b" ; oboInOwl:id "HP:0003514" ; a owl:Class ; rdfs:label "Deficiency or absence of cytochrome b(-245)" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0003517 oboInOwl:hasDbXref "UMLS:C1839271" ; oboInOwl:hasExactSynonym "Fetal overgrowth", "Foetal overgrowth" ; oboInOwl:id "HP:0003517" ; a owl:Class ; rdfs:label "Birth length greater than 97th percentile" ; rdfs:subClassOf obo:HP_0000098 . obo:HP_0003521 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs." ; oboInOwl:hasAlternativeId "HP:0001524", "HP:0003500", "HP:0008923" ; oboInOwl:hasDbXref "UMLS:C1846435" ; oboInOwl:hasExactSynonym "Disproportionate short-trunked dwarfism", "Disproportionate short-trunked short stature", "Short-trunked dwarfism" ; oboInOwl:id "HP:0003521" ; a owl:Class ; rdfs:label "Disproportionate short-trunk short stature" ; rdfs:subClassOf obo:HP_0003498, obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003524 obo:IAO_0000115 "A reduction in methionine synthase activity." ; oboInOwl:hasDbXref "UMLS:C1848580" ; oboInOwl:hasExactSynonym "Decreased activity of methionine synthase", "Methionine synthase activity decreased", "Methionine synthase deficiency", "Reduced methionine synthase activity" ; oboInOwl:id "HP:0003524" ; a owl:Class ; rdfs:comment "Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine, i.e., (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." ; rdfs:label "Decreased methionine synthase activity" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006555 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003526 obo:IAO_0000115 "Formation of crystals owing to an increased concentration of orotic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C3278626" ; oboInOwl:id "HP:0003526" ; a owl:Class ; rdfs:label "Orotic acid crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0003527 obo:IAO_0000115 "An increased concentration of prostaglandin in the urine." ; oboInOwl:hasDbXref "UMLS:C1866498" ; oboInOwl:hasExactSynonym "High urine prostaglandin levels" ; oboInOwl:id "HP:0003527" ; a owl:Class ; rdfs:label "Hyperprostaglandinuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26333 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003528 obo:IAO_0000115 "Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C1868394" ; oboInOwl:hasExactSynonym "Elevated calcitonin" ; oboInOwl:id "HP:0003528" ; a owl:Class ; rdfs:comment "Calcitonin is a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone." ; rdfs:label "Elevated circulating calcitonin concentration" ; rdfs:subClassOf obo:HP_0034902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000027222 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003529 obo:IAO_0000115 "An increase in the reabsorption of calcium by the renal tubulus that is not associated with increased parathormone levels." ; oboInOwl:hasDbXref "UMLS:C4025604" ; oboInOwl:hasExactSynonym "Parathormone-independent increased renal tubular Ca reabsorption", "Parathormone-independent increased renal tubular Ca2+ reabsorption" ; oboInOwl:id "HP:0003529" ; a owl:Class ; rdfs:comment "This feature is seen with familial hypocalciuric hypercalcemia. This disease has three known genetic etiologies, in type 1 there is a loss of function mutation in the calcium-sensing receptor (encoded by CASR), in type 2 there is a gain of function mutation in GNA11, which is involved in calcium-sensing receptor signaling, and in type 3 there is a mutation in AP2S1, which encodes the adaptor-related protein complex 2, sigma 1 subunit, which alters calcium-sensing receptor endocytosis." ; rdfs:label "Parathormone-independent increased renal tubular calcium reabsorption" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0003530 obo:IAO_0000115 "An increased concentration of glutaric acid in the blood." ; oboInOwl:hasDbXref "UMLS:C4025603" ; oboInOwl:hasExactSynonym "Glutarate acidemia", "Glutaric acidemia" ; oboInOwl:id "HP:0003530" ; a owl:Class ; rdfs:label "Elevated circulating glutaric acid concentration" ; rdfs:subClassOf obo:HP_0010995, obo:HP_0032368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17859 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003532 obo:IAO_0000115 "Level of ornithine in the urine above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C4025602" ; oboInOwl:hasExactSynonym "Ornithine high in urine" ; oboInOwl:id "HP:0003532" ; a owl:Class ; rdfs:label "Ornithinuria" ; rdfs:subClassOf obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003533 obo:IAO_0000115 "Decreased level of acetaldehyde dehydrogenase (ALDH). ALDH and alcohol dehydrogenase (ADH) are the primary enzymes involved in alcohol metabolism." ; oboInOwl:hasDbXref "UMLS:C4025601" ; oboInOwl:hasExactSynonym "Delayed oxidation of acetaldehyde" ; oboInOwl:id "HP:0003533" ; a owl:Class ; rdfs:comment "In the liver, alcohol dehydrogenase converts ethanol into acetaldehyde, which is then converted into acetic acid by acetaldehyde dehydrogenase." ; rdfs:label "Reduced acetaldehyde dehydrogenase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0003534 obo:IAO_0000115 "An abnormal reduction in xanthine dehydrogenase level." ; oboInOwl:hasDbXref "MSH:C562584", "SNOMEDCT_US:124147007", "SNOMEDCT_US:72682008", "UMLS:C0268118", "UMLS:C4025600" ; oboInOwl:hasRelatedSynonym "Xanthine dehydrogenase deficiency" ; oboInOwl:id "HP:0003534" ; a owl:Class ; rdfs:comment "This enzyme is on the purine degradation pathway and catalzyes the reaction xanthine + NAD+ + H2O = urate + NADH + H+." ; rdfs:label "Reduced xanthine dehydrogenase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_P47989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003535 obo:IAO_0000115 "An increased amount of 3-methylglutaconic acid in the urine." ; oboInOwl:hasDbXref "MSH:C579867", "SNOMEDCT_US:237950009", "UMLS:C3696376" ; oboInOwl:hasExactSynonym "3-Methylglutaconicaciduria" ; oboInOwl:id "HP:0003535" ; a owl:Class ; rdfs:comment "3-methylglutaconic aciduria describes five different disorders that impair mitochondrial function and resulting in buildup of 3-methylglutaconic acid and 3-methylglutaric acid and consequent increased excretion in the urine." ; rdfs:label "3-Methylglutaconic aciduria" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0003536 obo:IAO_0000115 "An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity." ; oboInOwl:hasDbXref "UMLS:C1853903" ; oboInOwl:id "HP:0003536" ; a owl:Class ; rdfs:comment "Fumarate hydratase belongs to the tricarboxylic acid (Krebs) cycle. It catalyzes the conversion of fumarate to malate." ; rdfs:label "Decreased fumarate hydratase activity" ; rdfs:subClassOf obo:HP_0000816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003537 obo:IAO_0000115 "An abnormally low level of uric acid in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:4519003", "UMLS:C0221333" ; oboInOwl:hasExactSynonym "Low blood uric acid levels" ; oboInOwl:id "HP:0003537" ; a owl:Class ; rdfs:label "Hypouricemia" ; rdfs:subClassOf obo:HP_0002157, obo:HP_0010932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003538 obo:IAO_0000115 "An increased level of iduronate-2-sulfatase activity in the blood." ; oboInOwl:hasDbXref "UMLS:C2673363", "UMLS:C4025599" ; oboInOwl:hasExactSynonym "Increased serum iduronate sulfatase level" ; oboInOwl:hasRelatedSynonym "Increased serum iduronate sulfatase" ; oboInOwl:id "HP:0003538" ; a owl:Class ; rdfs:comment "Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene are associated with Mucopolysaccharidosis Type II. Increased serum iduronate-2-sulfatase is observed in mucolipidosis II alpha/beta." ; rdfs:label "Increased iduronate sulfatase level" ; rdfs:subClassOf obo:HP_0034202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000008894 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003540 obo:IAO_0000115 "An impairment in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent." ; oboInOwl:hasAlternativeId "HP:0008177" ; oboInOwl:hasDbXref "UMLS:C1855853" ; oboInOwl:hasExactSynonym "Defective platelet aggregation", "Deficient platelet aggregation", "Platelet aggregation defect" ; oboInOwl:id "HP:0003540" ; a owl:Class ; rdfs:label "Impaired platelet aggregation" ; rdfs:subClassOf obo:HP_0030402 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070527 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003541 obo:IAO_0000115 "Excretion of glycosaminoglycan in the urine. Glycosaminoglycans are long unbranched polysaccharides consisting of a repeating disaccharide unit." ; oboInOwl:hasDbXref "UMLS:C4025598" ; oboInOwl:id "HP:0003541" ; a owl:Class ; rdfs:label "Urinary glycosaminoglycan excretion" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18085 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003542 obo:IAO_0000115 "An increased concentration of pyruvate in the blood." ; oboInOwl:hasDbXref "UMLS:C1849488" ; oboInOwl:hasExactSynonym "Increased serum pyruvic acid" ; oboInOwl:id "HP:0003542" ; a owl:Class ; rdfs:comment "An abnormal increase in the concentration of pyruvate in the blood. Pyruvate is involved in energy metabolism, forming part of glycolysis and the citric acid cycle." ; rdfs:label "Increased serum pyruvate" ; rdfs:subClassOf obo:HP_0004366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003546 obo:IAO_0000115 "A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender." ; oboInOwl:hasDbXref "SNOMEDCT_US:267044007", "UMLS:C0424551" ; oboInOwl:hasExactSynonym "Decreased ability to exercise", "Inability to exercise", "Low exercise endurance", "Poor exercise tolerance" ; oboInOwl:id "HP:0003546" ; a owl:Class ; rdfs:label "Exercise intolerance" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0003547 obo:IAO_0000115 "The shoulder, or pectoral, girdle is composed of the clavicles and the scapulae. Shoulder-girdle weakness refers to lack of strength of the muscles attaching to these bones, that is, lack of strength of the muscles around the shoulders." ; oboInOwl:hasAlternativeId "HP:0003695", "HP:0009009" ; oboInOwl:hasDbXref "SNOMEDCT_US:249940002", "UMLS:C0427063", "UMLS:C0748691" ; oboInOwl:hasExactSynonym "Muscle weakness, shoulder-girdle", "Shoulder girdle weakness", "Shoulder weakness", "Weak shoulder muscles" ; oboInOwl:id "HP:0003547" ; a owl:Class ; rdfs:label "Shoulder girdle muscle weakness" ; rdfs:subClassOf obo:HP_0001435, obo:HP_0003325 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003548 obo:IAO_0000115 "An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology." ; oboInOwl:hasDbXref "UMLS:C4025597" ; oboInOwl:id "HP:0003548" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by electron microscopy. This finding is typical of mitochondrial myopathies." ; rdfs:label "Subsarcolemmal accumulations of abnormally shaped mitochondria" ; rdfs:subClassOf obo:HP_0003800 . obo:HP_0003549 obo:IAO_0000115 "Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat)." ; oboInOwl:hasDbXref "UMLS:C4025596" ; oboInOwl:id "HP:0003549" ; a owl:Class ; rdfs:label "Abnormality of connective tissue" ; rdfs:subClassOf obo:HP_0033127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003550 obo:IAO_0000115 "Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs." ; oboInOwl:hasDbXref "UMLS:C1835228" ; oboInOwl:id "HP:0003550" ; a owl:Class ; rdfs:label "Predominantly lower limb lymphedema" ; rdfs:subClassOf obo:HP_0001004 . obo:HP_0003551 obo:IAO_0000115 "Reduced ability to climb stairs." ; oboInOwl:hasAlternativeId "HP:0007019" ; oboInOwl:hasDbXref "SNOMEDCT_US:282195009", "UMLS:C0239067" ; oboInOwl:hasExactSynonym "Difficulty walking up stairs" ; oboInOwl:id "HP:0003551" ; a owl:Class ; rdfs:label "Difficulty climbing stairs" ; rdfs:subClassOf obo:HP_0004302 . obo:HP_0003552 obo:IAO_0000115 "A condition in which muscles cannot be moved quickly without accompanying pain or spasm." ; oboInOwl:hasAlternativeId "HP:0009014" ; oboInOwl:hasDbXref "SNOMEDCT_US:16046003", "UMLS:C0221170" ; oboInOwl:id "HP:0003552" ; a owl:Class ; rdfs:label "Muscle stiffness" ; rdfs:subClassOf obo:HP_0011804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003553 obo:IAO_0100001 "HP:0100658" ; oboInOwl:id "HP:0003553" ; a owl:Class ; rdfs:label "obsolete Cellulitis due to immunodeficiency" ; owl:deprecated true . obo:HP_0003554 obo:IAO_0000115 "Atrophy (wasting) affecting primary type 2 muscle fibers. This feature in general can only be observed on muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C1864580" ; oboInOwl:hasExactSynonym "Type 2 fiber atrophy", "Type 2 fibre atrophy", "Type 2 muscle fibre atrophy" ; oboInOwl:id "HP:0003554" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by muscle biopsy." ; rdfs:label "Type 2 muscle fiber atrophy" ; rdfs:subClassOf obo:HP_0100295 . obo:HP_0003555 obo:IAO_0000115 "Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches." ; oboInOwl:hasDbXref "UMLS:C1836057" ; oboInOwl:hasExactSynonym "Fiber splitting", "Fibre splitting", "Muscle fibre splitting" ; oboInOwl:id "HP:0003555" ; a owl:Class ; rdfs:label "Muscle fiber splitting" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003557 obo:IAO_0000115 "An abnormally high degree of muscle fiber size variation. This phenotypic feature can be observed upon muscle biopsy." ; oboInOwl:hasAlternativeId "HP:0003556" ; oboInOwl:hasDbXref "UMLS:C1843700" ; oboInOwl:hasExactSynonym "Increased fiber size variation", "Increased fibre size variation", "Increased variability in muscle fiber size", "Increased variability in muscle fibre diameter", "Increased variability in muscle fibre size", "Increased variation in fiber size", "Increased variation in fibre size", "Increased variation in muscle fiber size", "Increased variation in muscle fibre size", "Variation in muscle fiber size", "Variation in muscle fibre size" ; oboInOwl:id "HP:0003557" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by muscle biopsy." ; rdfs:label "Increased variability in muscle fiber diameter" ; rdfs:subClassOf obo:HP_0012084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001958 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000188 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003558 obo:IAO_0000115 "Rhabdomyolysis induced by a viral infection." ; oboInOwl:hasDbXref "UMLS:C4025595" ; oboInOwl:id "HP:0003558" ; a owl:Class ; rdfs:label "Viral infection-induced rhabdomyolysis" ; rdfs:subClassOf obo:HP_0003201 . obo:HP_0003559 oboInOwl:hasDbXref "UMLS:C1853701" ; oboInOwl:id "HP:0003559" ; a owl:Class ; rdfs:label "Muscle hyperirritability" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0003560 obo:IAO_0000115 "The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities." ; oboInOwl:hasAlternativeId "HP:0003544", "HP:0003806" ; oboInOwl:hasDbXref "MSH:D009136", "SNOMEDCT_US:193225000", "SNOMEDCT_US:73297009", "UMLS:C0026850", "UMLS:C1864711" ; oboInOwl:hasRelatedSynonym "Muscle biopsy shows dystrophic changes" ; oboInOwl:id "HP:0003560" ; a owl:Class ; rdfs:comment "Muscular dystrophy can be demonstrated by muscle biopsy." ; rdfs:label "Muscular dystrophy" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003561 oboInOwl:hasDbXref "UMLS:C1855650" ; oboInOwl:hasExactSynonym "Birth length < 3rd percentile", "Birth length <3rd percentile" ; oboInOwl:id "HP:0003561" ; a owl:Class ; rdfs:label "Birth length less than 3rd percentile" ; rdfs:subClassOf obo:HP_0004322 . obo:HP_0003562 oboInOwl:hasDbXref "UMLS:C3277127" ; oboInOwl:id "HP:0003562" ; a owl:Class ; rdfs:label "Abnormal metaphyseal vascular invasion" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0003563 obo:IAO_0000115 "An decreased concentration of low-density lipoprotein cholesterol in the blood." ; oboInOwl:hasDbXref "MSH:D006995", "SNOMEDCT_US:190786004", "UMLS:C0020597", "UMLS:C0853085" ; oboInOwl:hasExactSynonym "Decreased LDLc concentration", "Decreased circulating low-density lipoprotein levels", "Hypobetalipoproteinemia" ; oboInOwl:hasRelatedSynonym "Decreased LDL" ; oboInOwl:id "HP:0003563" ; a owl:Class ; rdfs:comment "Beta-lipoprotein cholesterol is a synonym for low-density lipoprotein (LDL) cholesterol." ; rdfs:label "Decreased LDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010981, obo:HP_0031886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47774 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003564 obo:IAO_0000115 "The presence of a folate sensitive fragile site at chromosome Xq28." ; oboInOwl:hasDbXref "UMLS:C1839785" ; oboInOwl:id "HP:0003564" ; a owl:Class ; rdfs:comment "Fragile sites can be defined as heritable specific loci on human chromosomes that exhibit non-random gaps, constrictions or breaks when chromosomes are exposed to specific cell culture conditions. Over 120 different fragile sites have been identified in the human genome. Some of these sites are sensitive to folate, that is, they can be induced by a culture medium deficient in folic acid and thymidine, and hence a medium with lowered levels of dTTP or dCTP, two immediate components of DNA, or by a medium enriched either in methotrexate, an inhibitor of folate metabolism, or in fluorodeoxyuridine, an inhibitor of thymidylate synthesis. The folate-dependent fragile phenotype occurs if more than a critical number of CCG/CGG repeats are present (e.g., > 230 repeats for FRAXA)." ; rdfs:label "Folate-dependent fragile site at Xq28" ; rdfs:subClassOf obo:HP_0040012 . obo:HP_0003565 obo:IAO_0000115 "An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen." ; oboInOwl:hasDbXref "SNOMEDCT_US:165468009", "UMLS:C0151632" ; oboInOwl:hasExactSynonym "Elevated ESR", "Elevated sedimentation rate", "High ESR", "High erythrocyte sedimentation rate", "Increased erythrocyte sedimentation rate", "Raised erythrocyte sedimentation rate" ; oboInOwl:id "HP:0003565" ; a owl:Class ; rdfs:label "Elevated erythrocyte sedimentation rate" ; rdfs:subClassOf obo:HP_0025021, obo:HP_0033331 . obo:HP_0003566 obo:IAO_0000115 "An increased concentration of prostaglandin E2 in the blood." ; oboInOwl:hasAlternativeId "HP:0008298" ; oboInOwl:hasDbXref "UMLS:C3150358" ; oboInOwl:hasExactSynonym "Elevated prostaglandin E2" ; oboInOwl:id "HP:0003566" ; a owl:Class ; rdfs:label "Increased serum prostaglandin E2" ; rdfs:subClassOf obo:HP_0011023 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003568 obo:IAO_0000115 "A decreased level of glucose-6-phosphate isomerase." ; oboInOwl:hasAlternativeId "HP:0003290" ; oboInOwl:hasDbXref "SNOMEDCT_US:124669001", "UMLS:C1291611" ; oboInOwl:hasExactSynonym "Decreased glucose phosphate isomerase activity", "Glucosephosphate isomerase deficiency", "Phosphohexose isomerase deficiency" ; oboInOwl:id "HP:0003568" ; a owl:Class ; rdfs:comment "Deficiency of glucose-6-phosphate isomerase (EC 5.3.1.9)." ; rdfs:label "Decreased glucosephosphate isomerase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000008175 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003570 obo:IAO_0000115 "Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase." ; oboInOwl:hasDbXref "MSH:C535811", "SNOMEDCT_US:29692004", "UMLS:C0268119" ; oboInOwl:id "HP:0003570" ; a owl:Class ; rdfs:label "Molybdenum cofactor deficiency" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_60525 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003571 obo:IAO_0000115 "Increased concentration of proprionic acid in the blood circulation." ; oboInOwl:hasDbXref "MSH:D056693", "SNOMEDCT_US:124718009", "SNOMEDCT_US:69080001", "UMLS:C0268579" ; oboInOwl:id "HP:0003571" ; a owl:Class ; rdfs:label "Propionic acidemia" ; rdfs:subClassOf obo:HP_0032368 . obo:HP_0003572 obo:IAO_0000115 "A decreased concentration of citrulline in the blood." ; oboInOwl:hasDbXref "UMLS:C1839532" ; oboInOwl:id "HP:0003572" ; a owl:Class ; rdfs:label "Low plasma citrulline" ; rdfs:subClassOf obo:HP_0011965 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003573 obo:IAO_0000115 "Increased concentration of total (conjugated and unconjugated) bilirubin in the blood." ; oboInOwl:hasAlternativeId "HP:0008168" ; oboInOwl:hasDbXref "SNOMEDCT_US:176271000119108", "UMLS:C0741494" ; oboInOwl:hasExactSynonym "High bili total", "Increased bilirubin" ; oboInOwl:id "HP:0003573" ; a owl:Class ; rdfs:label "Increased total bilirubin" ; rdfs:subClassOf obo:HP_0002904 . obo:HP_0003574 obo:IAO_0000115 "A positive response to the regitine blocking test consisting of a substantial reduction in blood pressure following administration of regitine, indicative of the presence of increased levels of epinephrine and norepinephrine in the circulation, which is seen in pheochromocytoma-associated hypertension." ; oboInOwl:hasDbXref "UMLS:C4025594" ; oboInOwl:id "HP:0003574" ; a owl:Class ; rdfs:comment "Regitine produces an alpha-adrenergic block of relatively short duration. In the regitine blocking test, regitine is injected rapidly and bood pressure is recorded immediately after injection, at 30-second intervals for the first 3 minutes, and at 60-second intervals for the next 7 minutes. A positive response to the reginitine blocking test is present when the blood pressure is reduced more than 35 mmHg systolic and 25 mmHg diastolic. A typical positive response is a reduction in pressure of 60 mmHg systolic and 25 mmHg diastolic. A positive response is suggestive of pheochromocytoma and should generally be confirmed by other diagnostic procedures such as measurement of urinary catecholamines or their metabolites." ; rdfs:label "Positive regitine blocking test" ; rdfs:subClassOf obo:HP_0002640 . obo:HP_0003575 obo:IAO_0000115 "An abnormally increased sodium concentration in the cytosol." ; oboInOwl:hasDbXref "UMLS:C4025593" ; oboInOwl:hasExactSynonym "High intracellular Na", "Increased intracellular Na+ levels" ; oboInOwl:id "HP:0003575" ; a owl:Class ; rdfs:label "Increased intracellular sodium" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003577 obo:IAO_0000115 "A phenotypic abnormality that is present at birth." ; oboInOwl:hasAlternativeId "HP:0003595", "HP:0003601", "HP:0003624", "HP:0003660", "HP:0003666" ; oboInOwl:hasDbXref "UMLS:C1836142", "UMLS:C2752013" ; oboInOwl:hasExactSynonym "Onset at birth", "Symptoms present at birth" ; oboInOwl:id "HP:0003577" ; a owl:Class ; rdfs:comment "Congenital onset literally means present at birth. Congenital abnormalities are thus generally acquired during fetal development. Congenital abnormalities are often but not always hereditary in nature. Whether a disease manifestation is diagnosed to be intrauterine or congenital may depend on the time at which diagnostic procedures are performed. Thus, most congenital abnormalities are also intrauterine. This term should be used for phenotypic abnormalities or diseases initially observed at the time of birth. For abnormalities observed prior to (e.g., by fetal ultrasound), use the term Antenatal onset (HP:0030674)." ; rdfs:label "Congenital onset" ; rdfs:subClassOf obo:HP_0003674 . obo:HP_0003581 obo:IAO_0000115 "Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later." ; oboInOwl:hasAlternativeId "HP:0003585", "HP:0003598", "HP:0003627", "HP:0003662", "HP:0003669" ; oboInOwl:hasDbXref "UMLS:C1853562" ; oboInOwl:hasExactSynonym "Onset in adulthood", "Onset in early adulthood", "Symptoms begin in adulthood" ; oboInOwl:id "HP:0003581" ; a owl:Class ; rdfs:label "Adult onset" ; rdfs:subClassOf obo:HP_0003674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000087 ] ) ] . obo:HP_0003584 obo:IAO_0000115 "A type of adult onset with onset of symptoms after the age of 60 years." ; oboInOwl:hasDbXref "UMLS:C4025592" ; oboInOwl:id "HP:0003584" ; a owl:Class ; rdfs:label "Late onset" ; rdfs:subClassOf obo:HP_0003581 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000091 ] ) ] . obo:HP_0003587 obo:IAO_0000115 "Gradual, very slow onset of disease manifestations." ; oboInOwl:hasDbXref "SNOMEDCT_US:367326009", "SNOMEDCT_US:61751001", "UMLS:C0332164", "UMLS:C1298634" ; oboInOwl:hasExactSynonym "Gradual onset" ; oboInOwl:id "HP:0003587" ; a owl:Class ; rdfs:label "Insidious onset" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0003593 obo:IAO_0000115 "Onset of signs or symptoms of disease between 28 days to one year of life." ; oboInOwl:hasAlternativeId "HP:0003576", "HP:0003579", "HP:0003591", "HP:0003594", "HP:0003599", "HP:0003600", "HP:0003629", "HP:0003631", "HP:0003667", "HP:0003672", "HP:0010573" ; oboInOwl:hasDbXref "UMLS:C1848924" ; oboInOwl:hasExactSynonym "Infantile onset", "Onset in first year of life", "Onset in infancy" ; oboInOwl:id "HP:0003593" ; a owl:Class ; rdfs:comment "Onset of signs or symptoms of disease within the first 12 months of life." ; rdfs:label "Infantile onset" ; rdfs:subClassOf obo:HP_0410280 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000083 ] ) ] . obo:HP_0003596 obo:IAO_0000115 "A type of adult onset with onset of symptoms at the age of 40 to 60 years." ; oboInOwl:hasDbXref "UMLS:C1969363" ; oboInOwl:id "HP:0003596" ; a owl:Class ; rdfs:comment "Middle age is of course not amenable to precise definitions. We suggest using this term for onset of disease symptoms between the age of 40 and 60 years." ; rdfs:label "Middle age onset" ; rdfs:subClassOf obo:HP_0003581 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000092 ] ) ] . obo:HP_0003606 obo:IAO_0000115 "Lack of urothione (the urinary metabolite of molybdenum cofactor) in the urine." ; oboInOwl:hasDbXref "UMLS:C4025591" ; oboInOwl:id "HP:0003606" ; a owl:Class ; rdfs:comment "Urothione, a sulfur-containing pterin, is the normal metabolic degradation product of the molybdenum cofactor." ; rdfs:label "Absent urinary urothione" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0003607 obo:IAO_0000115 "Increased concentration of 4-hydroxyphenylacetic acid in the urine." ; oboInOwl:hasAlternativeId "HP:0033304" ; oboInOwl:hasDbXref "MSH:C535315", "UMLS:C1848680" ; oboInOwl:hasExactSynonym "Elevated urine 4-hydroxyphenylacetic acid level" ; oboInOwl:id "HP:0003607" ; a owl:Class ; rdfs:comment "4-Hydroxyphenylpyruvate dioxygenase participates in the tyrosine catabolic pathway by catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate. A deficiency in this enzyme can result in 4-Hydroxyphenylacetic aciduria." ; rdfs:label "4-hydroxyphenylacetic aciduria" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003609 obo:IAO_0000115 "The presence of foam cells that contain lamellar inclusion bodies." ; oboInOwl:hasDbXref "UMLS:C4025590" ; oboInOwl:id "HP:0003609" ; a owl:Class ; rdfs:comment "Foam cells with lamellar inclusion bodies are thought to be a hallmark of cellular phospholipidosis, i.e., of the excess accumulation of phospholipids. This abnormality can be assayed by electron microscopy." ; rdfs:label "Foam cells with lamellar inclusion bodies" ; rdfs:subClassOf obo:HP_0003651 . obo:HP_0003610 obo:IAO_0000115 "Increased cytoplasmic staining of fibroblasts with toluidine blue." ; oboInOwl:hasDbXref "UMLS:C1835008" ; oboInOwl:id "HP:0003610" ; a owl:Class ; rdfs:comment "Cultured fibroblasts from the genetic mucopolysaccharidoses store higher than normal amounts of glycosaminoglyeans. Histochemical stains such as toluidine blue and Alcian blue can be used to detect such intracellular glycosaminoglycans which, being negatively charged, are bound and precipitated by the cationic dyes. Cultured fibroblasts from homozygotes -and heterozygotes for the genetic mucopolysaccharidoses accumulate excessive quantities of glycosaminoglycans. The cytoplasmic staining with toluidine blue is referred to as metachromasia (pink) and orthochromasia (blue) and that with Alcian blue as alcianophilia." ; rdfs:label "Fibroblast metachromasia" ; rdfs:subClassOf obo:HP_0003653 . obo:HP_0003612 obo:IAO_0000115 "If positive, the ferric chloride test indicates an increased concentration of phenols in the urine or blood." ; oboInOwl:hasDbXref "UMLS:C4025589" ; oboInOwl:hasExactSynonym "Positive FeCl3 test" ; oboInOwl:id "HP:0003612" ; a owl:Class ; rdfs:comment "The ferric chloride test indicates presence of high levels of phenylpyruvate in urine, because ferric ion forms a blue-green colored complex with phenylpyruvate. Some other compounds can also lead to a positive ferric chloride test. The ferric chloride test is no longer used in modern clinical practice, but this term is kept for historical reasons. The urine phenylpyruvate concentration is elevated in phenylketonuria." ; rdfs:label "Positive ferric chloride test" ; rdfs:subClassOf obo:HP_0010893 . obo:HP_0003613 obo:IAO_0000115 "The presence of circulating autoantibodies to phospholipids." ; oboInOwl:hasDbXref "UMLS:C4019436" ; oboInOwl:hasExactSynonym "Antiphospholipid antibodies", "Antiphospholipid antibody", "Phospholipid antibody positivity" ; oboInOwl:id "HP:0003613" ; a owl:Class ; rdfs:comment "This group of autoantibodies comprises anticardiolipin, antiphosphatidylinositol, atiphosphatidylglycerol, and antiphosphatidylserine antibodies." ; rdfs:label "Antiphospholipid antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0003614 obo:IAO_0000115 "Increased concentration of trimethylamine in the urine." ; oboInOwl:hasDbXref "MSH:C536561", "SNOMEDCT_US:237959005", "UMLS:C0342739" ; oboInOwl:hasExactSynonym "High urine trimethylamine levels" ; oboInOwl:id "HP:0003614" ; a owl:Class ; rdfs:comment "Increased concentration of trimethylamine, an organic amino compound with an oder characterized as that of rotting fish, in the urine. Trimethylaminuria is generally caused by impaired oxidation of trimethylamine into the odorless compound trimethylamine N-oxide." ; rdfs:label "Trimethylaminuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003616 oboInOwl:hasDbXref "UMLS:C1849316" ; oboInOwl:id "HP:0003616" ; a owl:Class ; rdfs:label "Premature separation of centromeric heterochromatin" ; rdfs:subClassOf obo:HP_0200024 . obo:HP_0003621 obo:IAO_0000115 "Onset of signs or symptoms of disease between the age of 5 and 15 years." ; oboInOwl:hasAlternativeId "HP:0003578", "HP:0003580", "HP:0003582", "HP:0003583", "HP:0003589", "HP:0003592", "HP:0003604", "HP:0003619", "HP:0003620", "HP:0003625", "HP:0003659", "HP:0003661", "HP:0003670" ; oboInOwl:hasDbXref "UMLS:C4025588" ; oboInOwl:hasExactSynonym "Signs and symptoms begin before 15 years of age" ; oboInOwl:id "HP:0003621" ; a owl:Class ; rdfs:label "Juvenile onset" ; rdfs:subClassOf obo:HP_0410280 . obo:HP_0003623 obo:IAO_0000115 "Onset of signs or symptoms of disease within the first 28 days of life." ; oboInOwl:hasAlternativeId "HP:0003622" ; oboInOwl:hasDbXref "UMLS:C1855106" ; oboInOwl:hasExactSynonym "Neonatal onset", "Onset in first weeks of life", "Onset in neonatal period" ; oboInOwl:id "HP:0003623" ; a owl:Class ; rdfs:label "Neonatal onset" ; rdfs:subClassOf obo:HP_0003674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000082 ] ) ] . obo:HP_0003634 obo:IAO_0000115 "Congenital lack of development of the muscles, which are then replaced by a mixture of dense fat and fibrous tissue." ; oboInOwl:hasAlternativeId "HP:0008990" ; oboInOwl:hasDbXref "SNOMEDCT_US:205532005", "UMLS:C0432185" ; oboInOwl:hasExactSynonym "Absent muscles since birth", "Congenital absence of muscles" ; oboInOwl:id "HP:0003634" ; a owl:Class ; rdfs:label "Amyoplasia" ; rdfs:subClassOf obo:HP_0100854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003635 obo:IAO_0000115 "Loss (disappearance) of previously present subcutaneous fat tissue in arm or leg." ; oboInOwl:hasAlternativeId "HP:0003757" ; oboInOwl:hasDbXref "UMLS:C1837764" ; oboInOwl:hasExactSynonym "Loss of fat tissue below the skin in limbs", "Loss of subcutaneous adipose tissue from extremities" ; oboInOwl:id "HP:0003635" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Loss of subcutaneous adipose tissue in limbs" ; rdfs:subClassOf obo:HP_0008887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003637 obo:IAO_0000115 "An abnormal reduction in 4-hydroxyphenylpyruvate dioxygenase level." ; oboInOwl:hasDbXref "UMLS:C4025587" ; oboInOwl:hasExactSynonym "Reducted HPPD activity" ; oboInOwl:id "HP:0003637" ; a owl:Class ; rdfs:comment "Note: 4-hydroxyphenylpyruvate dioxygenase corresponds to EC 1.13.11.27. 4-Hydroxyphenylpyruvate dioxygenase participates in the tyrosine catabolic pathway by catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate. A deficiency in this enzyme can result in 4-Hydroxyphenylacetic aciduria." ; rdfs:label "Reduced 4-Hydroxyphenylpyruvate dioxygenase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_P32754 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003639 obo:IAO_0000115 "The concentration of epinephrine in the urine, normalized for urine concentration, is above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C1868393" ; oboInOwl:hasExactSynonym "Increased urinary epinephrine" ; oboInOwl:id "HP:0003639" ; a owl:Class ; rdfs:label "Elevated urinary epinephrine level" ; rdfs:subClassOf obo:HP_0011976 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003640 obo:IAO_0000115 "The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the central nervous system." ; oboInOwl:hasDbXref "UMLS:C1843373" ; oboInOwl:id "HP:0003640" ; a owl:Class ; rdfs:label "CNS foam cells" ; rdfs:subClassOf obo:HP_0003651 . obo:HP_0003641 obo:IAO_0000115 "The presence of free hemoglobin in the urine." ; oboInOwl:hasDbXref "MSH:D006456", "SNOMEDCT_US:68600005", "UMLS:C0019048" ; oboInOwl:hasExactSynonym "Haemoglobin in urine", "Hemoglobin in urine" ; oboInOwl:id "HP:0003641" ; a owl:Class ; rdfs:comment "If, following hemolysis, haptoglobins (hemoglobin-binding proteins) are saturated, then free hemoglobin appears in the urine." ; rdfs:label "Hemoglobinuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_35143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003642 obo:IAO_0000115 "Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II." ; oboInOwl:hasDbXref "UMLS:C1837899" ; oboInOwl:hasExactSynonym "Abnormal isoelectric focusing of serum transferrin, type I pattern", "Isoelectric focusing of serum transferrin consistent with CDG type I", "Type 1 transferrin isoform profile" ; oboInOwl:id "HP:0003642" ; a owl:Class ; rdfs:comment "There are several methods in use with which this feature can be diagnosed. Using HPLC analysis an increased asialo- and disialotransferrin and reduced tetrasialotransferrin are observed. Using immunoaffinity column analysis, the mono-oligosaccharide/di-oligosaccharide transferrin ratio, and/or the a-oligosaccharide/di-oligosaccharide transferrin ratio are abnormal." ; rdfs:label "Type I transferrin isoform profile" ; rdfs:subClassOf obo:HP_0003160 . obo:HP_0003643 obo:IAO_0000115 "Abnormally reduced sulfite oxidase level." ; oboInOwl:hasDbXref "MSH:C538141", "SNOMEDCT_US:367368009", "UMLS:C0268624" ; oboInOwl:id "HP:0003643" ; a owl:Class ; rdfs:comment "Sulfite oxidase is responsible for the oxidation of sulfite to sulfate and is the terminal enzyme in the oxidative degradation pathway of sulfur-containing amino acids." ; rdfs:label "Sulfite oxidase deficiency" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008482 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003645 obo:IAO_0000115 "Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms." ; oboInOwl:hasDbXref "SNOMEDCT_US:409675001", "UMLS:C0240671" ; oboInOwl:hasExactSynonym "Abnormal partial thromboplastin time", "Delayed thromboplastin generation", "Partial thromboplastin time prolonged", "Prolonged PTT", "Prolonged activated partial thromboplastin time" ; oboInOwl:id "HP:0003645" ; a owl:Class ; rdfs:label "Prolonged partial thromboplastin time" ; rdfs:subClassOf obo:HP_0001928 . obo:HP_0003646 obo:IAO_0000115 "Abnormally increased concentration of hydrogencarbonate in the urine." ; oboInOwl:hasDbXref "UMLS:C1839865" ; oboInOwl:hasExactSynonym "Increased urine HCO3 concentration", "Increased urine bicarbonate concentration" ; oboInOwl:id "HP:0003646" ; a owl:Class ; rdfs:label "Bicarbonaturia" ; rdfs:subClassOf obo:HP_0011279 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003647 obo:IAO_0000115 "A deficiency of the electron transfer flavoprotein-ubiquinone oxidoreductase." ; oboInOwl:hasDbXref "UMLS:C4025586" ; oboInOwl:id "HP:0003647" ; a owl:Class ; rdfs:label "Electron transfer flavoprotein-ubiquinone oxidoreductase defect" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0003648 obo:IAO_0000115 "An increased concentration of lactic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C4025585" ; oboInOwl:hasExactSynonym "High urine lactic acid levels", "Increased urine lactate" ; oboInOwl:id "HP:0003648" ; a owl:Class ; rdfs:label "Lacticaciduria" ; rdfs:subClassOf obo:HP_0012072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28358 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003649 obo:IAO_0000115 "Abnormality of glycoside metabolism." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:32:00Z" ; oboInOwl:hasDbXref "UMLS:C4025584" ; oboInOwl:id "HP:0003649" ; a owl:Class ; rdfs:comment "Glycosides are molecules with a suger moiety bound to some other moiety." ; rdfs:label "Abnormality of glycoside metabolism" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0016137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003651 obo:IAO_0000115 "The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance." ; oboInOwl:hasAlternativeId "HP:0003650" ; oboInOwl:hasDbXref "MSH:D005487", "SNOMEDCT_US:16980002", "UMLS:C0016390" ; oboInOwl:hasExactSynonym "Foamy histiocytes", "Foamy macrophages", "Lipid-laden histiocytes", "Presence of foam cells" ; oboInOwl:id "HP:0003651" ; a owl:Class ; rdfs:comment "Foam cells may contain polymorphic cytoplasmic inclusions consisting of lamellar osmiophilic membranes on electron microscopy." ; rdfs:label "Foam cells" ; rdfs:subClassOf obo:HP_0002621 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000891 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003652 obo:IAO_0000115 "Recurring episodes of myoglobinuria, i.e., of the presence of myoglobin in the urine. This is usually a consequence of rhabdomyolysis, i.e., of the destruction of muscle tissue." ; oboInOwl:hasAlternativeId "HP:0008313" ; oboInOwl:hasDbXref "MSH:C564018", "UMLS:C1838877" ; oboInOwl:hasExactSynonym "Myoglobinuria, episodic", "Myoglobinuria, recurrent" ; oboInOwl:id "HP:0003652" ; a owl:Class ; rdfs:label "Recurrent myoglobinuria" ; rdfs:subClassOf obo:HP_0002913 . obo:HP_0003653 obo:IAO_0000115 "Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans." ; oboInOwl:hasDbXref "UMLS:C4025583" ; oboInOwl:id "HP:0003653" ; a owl:Class ; rdfs:comment "This investigation is no longer in common use." ; rdfs:label "Cellular metachromasia" ; rdfs:subClassOf obo:HP_0011020 . obo:HP_0003654 obo:IAO_0000115 "An abnormal reduction in dihydropyrimidine dehydrogenase (NADP+) level." ; oboInOwl:hasDbXref "MSH:D054067", "SNOMEDCT_US:77365006", "UMLS:C1959620", "UMLS:C4025582" ; oboInOwl:hasRelatedSynonym "Dihydropyrimidine dehydrogenase deficiency" ; oboInOwl:id "HP:0003654" ; a owl:Class ; rdfs:comment "Pyrimidine 5-prime nucleotidase catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates to the corresponding nucleosides." ; rdfs:label "Reduced dihydropyrimidine dehydrogenase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_Q12882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003655 obo:IAO_0000115 "An abnormality of glycoprotein metabolism related to a decreased level of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity." ; oboInOwl:hasDbXref "UMLS:C4021725" ; oboInOwl:hasExactSynonym "Deficient N-acetylglucosaminyltransferase II" ; oboInOwl:id "HP:0003655" ; a owl:Class ; rdfs:label "Reduced level of N-acetylglucosaminyltransferase II" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_Q10469 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003656 obo:IAO_0000115 "Reduced level of the enzyme beta-glucosidase, an enzyme that catalyzes the hydrolysis of glucosylceramide into ceramide and glucose." ; oboInOwl:hasDbXref "UMLS:C1842710" ; oboInOwl:hasExactSynonym "Decreased lysosomal acid glucosylceramidase activity" ; oboInOwl:id "HP:0003656" ; a owl:Class ; rdfs:comment "An enzyme that hydrolyzes beta-glucosides in cerebrosides." ; rdfs:label "Decreased beta-glucocerebrosidase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0003657 obo:IAO_0000115 "Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide. Deposition of granular osmiophilic material (GOM) is the vascular pathological hallmark of CADASIL, which is the most prevalent hereditary small vessel disease and is caused by missense mutations in the NOTCH3 gene. GOM have been shown to contain NOTCH3 ectodomain (NOTCH3ECD) and extracellular matrix proteins, and can be visualized ultrastructurally in the tunica media of small arteries and capillaries. These electron dense GOM deposits are located in the basement membrane of mural cells, i.e. vascular smooth muscle cells and pericytes. In both manifest and pre-manifest CADASIL patients, GOM deposits are present not only in brain vessels, but also in vessels of other organs, such as the skin." ; oboInOwl:hasAlternativeId "HP:0034379" ; oboInOwl:hasDbXref "UMLS:C1859833" ; oboInOwl:hasExactSynonym "Granular osmiophilic deposits (GROD) in cells" ; oboInOwl:id "HP:0003657" ; a owl:Class ; rdfs:comment "In CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy), GOM deposits can be observed located in the neighbourhood of the smooth muscle cells, often within an infolding of the cell membrane." ; rdfs:label "Vascular granular osmiophilic material deposition" ; rdfs:subClassOf obo:HP_0025015 . obo:HP_0003658 obo:IAO_0000115 "A decreased concentration of methionine in the blood." ; oboInOwl:hasDbXref "UMLS:C1848555" ; oboInOwl:hasExactSynonym "Decreased plasma methionine", "Decreased serum methionine" ; oboInOwl:id "HP:0003658" ; a owl:Class ; rdfs:comment "Normal methionine blood levels are around 30 micromole per liter." ; rdfs:label "Hypomethioninemia" ; rdfs:subClassOf obo:HP_0010901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16811 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003665 obo:IAO_0000115 "Muscular atrophy affecting the muscles of the pelvis." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T10:57:00Z" ; oboInOwl:hasDbXref "UMLS:C4025581" ; oboInOwl:id "HP:0003665" ; a owl:Class ; rdfs:label "Amyotrophy of the musculature of the pelvis" ; rdfs:subClassOf obo:HP_0008988 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003202 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003674 obo:IAO_0000115 "The age group in which disease manifestations appear." ; oboInOwl:hasAlternativeId "HP:0003588", "HP:0003590", "HP:0003597", "HP:0003602", "HP:0003603", "HP:0003618", "HP:0003626", "HP:0003628", "HP:0003630", "HP:0003663", "HP:0003664", "HP:0003668", "HP:0011007" ; oboInOwl:hasDbXref "MSH:D017668", "UMLS:C0206132" ; oboInOwl:hasExactSynonym "Age of onset", "Age symptoms begin" ; oboInOwl:id "HP:0003674" ; a owl:Class ; rdfs:comment "Adolescent is defined by WHO as a person between 10-19 years of age." ; rdfs:label "Onset" ; rdfs:subClassOf obo:HP_0031797 . obo:HP_0003676 obo:IAO_0000115 "Applies to a disease manifestation that increases in scope or severity over the course of time, i.e., that worsens with age." ; oboInOwl:hasDbXref "SNOMEDCT_US:252157006", "SNOMEDCT_US:255314001", "UMLS:C0205329", "UMLS:C1864985" ; oboInOwl:hasExactSynonym "Worsens with time" ; oboInOwl:hasRelatedSynonym "Progressive disorder" ; oboInOwl:id "HP:0003676" ; a owl:Class ; rdfs:label "Progressive" ; rdfs:subClassOf obo:HP_0003679 . obo:HP_0003677 obo:IAO_0000115 "Applies to a disease manifestation that only slowly increases in scope or severity over the course of time." ; oboInOwl:hasAlternativeId "HP:0003675", "HP:0003681" ; oboInOwl:hasDbXref "UMLS:C1854494" ; oboInOwl:hasExactSynonym "Signs and symptoms worsen slowly with time", "Slow disease progression", "Slow progression", "Slowly progressive disorder" ; oboInOwl:id "HP:0003677" ; a owl:Class ; rdfs:label "Slowly progressive" ; rdfs:subClassOf obo:HP_0003679 . obo:HP_0003678 obo:IAO_0000115 "Applies to a disease manifestation that quickly increases in scope or severity over the course of time." ; oboInOwl:hasDbXref "UMLS:C1838681", "UMLS:C1850776" ; oboInOwl:hasExactSynonym "Rapid progression", "Worsening quickly" ; oboInOwl:hasRelatedSynonym "Rapidly progressive disorder" ; oboInOwl:id "HP:0003678" ; a owl:Class ; rdfs:label "Rapidly progressive" ; rdfs:subClassOf obo:HP_0003679 . obo:HP_0003679 oboInOwl:hasDbXref "UMLS:C4025580" ; oboInOwl:id "HP:0003679" ; a owl:Class ; rdfs:label "Pace of progression" ; rdfs:subClassOf obo:HP_0031797 . obo:HP_0003680 obo:IAO_0000115 "Applies to a disease manifestation that does not increase in scope or severity over the course of time, i.e., that does not worsen with age." ; oboInOwl:hasAlternativeId "HP:0003685" ; oboInOwl:hasDbXref "SNOMEDCT_US:702322003", "UMLS:C3839460" ; oboInOwl:hasExactSynonym "Does not worsen", "Non-progressive", "Nonprogressive course", "Nonprogressive disorder", "Stationary" ; oboInOwl:id "HP:0003680" ; a owl:Class ; rdfs:label "Nonprogressive" ; rdfs:subClassOf obo:HP_0003679 . obo:HP_0003682 obo:IAO_0000115 "Applies to a disease manifestation that quickly increases in scope or severity with a rate that varies. For instance, progression may be slow in one time period and rapid in another." ; oboInOwl:hasDbXref "UMLS:C1970284" ; oboInOwl:id "HP:0003682" ; a owl:Class ; rdfs:label "Variable progression rate" ; rdfs:subClassOf obo:HP_0003679 . obo:HP_0003683 obo:IAO_0100001 "HP:0000444" ; oboInOwl:id "HP:0003683" ; a owl:Class ; rdfs:label "obsolete Large beaked nose" ; owl:deprecated true . obo:HP_0003687 obo:IAO_0000115 "An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells)." ; oboInOwl:hasDbXref "UMLS:C1842170" ; oboInOwl:hasExactSynonym "Central nuclei", "Centralised nuclei", "Centralised sarcomeric nuclei", "Centralized nuclei", "Centralized sarcomeric nuclei", "Centrally nucleated skeletal muscle fibres" ; oboInOwl:id "HP:0003687" ; a owl:Class ; rdfs:comment "Normally, the nuclei of muscle cells are located peripherally, immediately under the plasma membrane (sarcolemma)." ; rdfs:label "Centrally nucleated skeletal muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003688 obo:IAO_0000115 "An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue." ; oboInOwl:hasAlternativeId "HP:0003734", "HP:0009006" ; oboInOwl:hasDbXref "UMLS:C4021724" ; oboInOwl:hasExactSynonym "Cytochrome C oxidase-negative muscle fibres", "Cytochrome c oxidase deficiency in skeletal muscle", "Decreased activity of cytochrome C oxidase in muscle tissue", "Decreased skeletal muscle cytochrome c oxidase activity" ; oboInOwl:id "HP:0003688" ; a owl:Class ; rdfs:comment "This abnormality can be assayed by muscle biopsy. Cytochrome C oxidase is an enzyme of the respiratory electron transport chain of mitochondria that is located in the mitochondrial membrane." ; rdfs:label "Cytochrome C oxidase-negative muscle fibers" ; rdfs:subClassOf obo:HP_0003800 . obo:HP_0003689 obo:IAO_0000115 "The presence of multiple deletions of mitochondrial DNA (mtDNA)." ; oboInOwl:hasAlternativeId "HP:0003801" ; oboInOwl:hasDbXref "UMLS:C3277376" ; oboInOwl:hasExactSynonym "Multiple mtDNA deletions" ; oboInOwl:id "HP:0003689" ; a owl:Class ; rdfs:comment "This feature can be demonstrated by muscle biopsy." ; rdfs:label "Multiple mitochondrial DNA deletions" ; rdfs:subClassOf obo:HP_0009141 . obo:HP_0003690 obo:IAO_0000115 "Reduced strength and weakness of the muscles of the arms and legs." ; oboInOwl:hasAlternativeId "HP:0002534" ; oboInOwl:hasDbXref "SNOMEDCT_US:713514005", "UMLS:C0587246" ; oboInOwl:hasExactSynonym "Limb muscle weakness", "Limb weakness" ; oboInOwl:id "HP:0003690" ; a owl:Class ; rdfs:label "Limb muscle weakness" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003691 obo:IAO_0000115 "Abnormal protrusion of the scapula away from the surface of the back." ; oboInOwl:hasAlternativeId "HP:0000783" ; oboInOwl:hasDbXref "MEDDRA:10067628", "SNOMEDCT_US:17211005", "UMLS:C0240953", "UMLS:C4072849" ; oboInOwl:hasExactSynonym "Scapula alata", "Winged scapulae", "Winged scapulas", "Winged shoulder blade" ; oboInOwl:hasRelatedSynonym "Scapular weakness" ; oboInOwl:id "HP:0003691" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The serratus anterior muscle is responsible for controlling the scapula (shoulder blade), and weakness of this muscle (which may be caused by damage to the long thoracic nerve) can manifest as scular winging." ; rdfs:label "Scapular winging" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0001435 . obo:HP_0003693 obo:IAO_0000115 "Muscular atrophy affecting muscles in the distal portions of the extremities." ; oboInOwl:hasAlternativeId "HP:0002484", "HP:0002934", "HP:0003486", "HP:0003699", "HP:0006786", "HP:0006864", "HP:0008937", "HP:0008958", "HP:0009015", "HP:0009040", "HP:0009065" ; oboInOwl:hasDbXref "UMLS:C1848736" ; oboInOwl:hasExactSynonym "Amyotrophy of distal limb muscles", "Distal amyotrophy, especially of the hands and feet", "Distal limb muscle atrophy", "Distal muscle atrophy", "Distal muscle atrophy, upper and lower limbs", "Distal muscle degeneration", "Distal muscle wasting", "Distal muscular atrophy", "Muscle atrophy, distal" ; oboInOwl:id "HP:0003693" ; a owl:Class ; rdfs:comment "Most polyneuropathies affect distal lower extremity miuscles early on. Polyneuropathies are roughly symmeetric in distribution and tend to affect nerves in a length-dependent manner, with the longest nerves first (stocking-glove distribution)." ; rdfs:label "Distal amyotrophy" ; rdfs:subClassOf obo:HP_0003202 . obo:HP_0003694 obo:IAO_0000115 "Lack of strength of the proximal musculature occurring late in the clinical course." ; oboInOwl:hasDbXref "UMLS:C4025578" ; oboInOwl:id "HP:0003694" ; a owl:Class ; rdfs:label "Late-onset proximal muscle weakness" ; rdfs:subClassOf obo:HP_0003701 . obo:HP_0003696 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T01:37:43Z" ; oboInOwl:hasDbXref "UMLS:C4025577" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the little finger", "Absent end part of the outermost bone of the pinkie finger", "Absent end part of the outermost bone of the pinky finger" ; oboInOwl:id "HP:0003696" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009382, obo:HP_0010246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003697 obo:IAO_0000115 "Muscular atrophy in the distribution of shoulder girdle and peroneal muscles." ; oboInOwl:hasAlternativeId "HP:0006920", "HP:0008957" ; oboInOwl:hasDbXref "UMLS:C1842162" ; oboInOwl:hasExactSynonym "Scapuloperoneal atrophy" ; oboInOwl:id "HP:0003697" ; a owl:Class ; rdfs:label "Scapuloperoneal amyotrophy" ; rdfs:subClassOf obo:HP_0003202 . obo:HP_0003698 oboInOwl:hasDbXref "SNOMEDCT_US:249902000", "UMLS:C0241237" ; oboInOwl:hasExactSynonym "Difficulty in standing", "Standing instability" ; oboInOwl:id "HP:0003698" ; a owl:Class ; rdfs:label "Difficulty standing" ; rdfs:subClassOf obo:HP_0004302 . obo:HP_0003700 obo:IAO_0000115 "Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles." ; oboInOwl:hasAlternativeId "HP:0008977", "HP:0008987", "HP:0008996", "HP:0009043", "HP:0009052", "HP:0009068", "HP:0009074" ; oboInOwl:hasDbXref "UMLS:C1389113" ; oboInOwl:hasExactSynonym "Diffuse amyotrophy", "Diffuse muscle atrophy", "Diffuse muscle wasting", "Diffuse skeletal muscle wasting", "Generalised amyotrophy", "Generalised muscle atrophy", "Generalised muscle degeneration", "Generalized muscle atrophy", "Generalized muscle degeneration", "Muscle atrophy, diffuse", "Muscle atrophy, generalised", "Muscle atrophy, generalized", "Muscular atrophy, generalised", "Muscular atrophy, generalized" ; oboInOwl:id "HP:0003700" ; a owl:Class ; rdfs:label "Generalized amyotrophy" ; rdfs:subClassOf obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0003701 obo:IAO_0000115 "A lack of strength of the proximal muscles." ; oboInOwl:hasAlternativeId "HP:0003432", "HP:0003475", "HP:0007195", "HP:0008950", "HP:0008961", "HP:0008975", "HP:0009033", "HP:0009075" ; oboInOwl:hasDbXref "SNOMEDCT_US:249939004", "UMLS:C0221629", "UMLS:C1838869" ; oboInOwl:hasExactSynonym "Muscle weakness, proximal", "Proximal limb muscle weakness", "Proximal limb weakness", "Weakness in muscles of upper arms and upper legs" ; oboInOwl:hasRelatedSynonym "Proximal neurogenic muscle weakness" ; oboInOwl:id "HP:0003701" ; a owl:Class ; rdfs:comment "Removed logical definition that used anonymous class. Outstanding term request in UBERON for proximal muscle organ." ; rdfs:label "Proximal muscle weakness" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0003704 oboInOwl:hasDbXref "UMLS:C1842161" ; oboInOwl:hasExactSynonym "Neurogenic scapuloperoneal syndrome" ; oboInOwl:id "HP:0003704" ; a owl:Class ; rdfs:label "Scapuloperoneal weakness" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0003707 obo:IAO_0000115 "Enlargement of the muscles of the calf due to their replacement by connective tissue or fat." ; oboInOwl:hasDbXref "UMLS:C1839666" ; oboInOwl:hasExactSynonym "Pseudohypertrophy of the calves" ; oboInOwl:id "HP:0003707" ; a owl:Class ; rdfs:comment "Pseudohypertrophy of the calf musculature is commonly seen in certain muscular dystrophies but also with spinal muscular atrophy and other denervating conditions." ; rdfs:label "Calf muscle pseudohypertrophy" ; rdfs:subClassOf obo:HP_0001430 . obo:HP_0003710 obo:IAO_0000115 "Sudden and involuntary contractions of one or more muscles brought on by physical exertion." ; oboInOwl:hasAlternativeId "HP:0008983", "HP:0009000" ; oboInOwl:hasDbXref "UMLS:C1855578" ; oboInOwl:hasExactSynonym "Exercise-induced muscle cramping", "Exercise-induced muscle cramps", "Muscle cramps following exercise", "Muscle cramps on exercise", "Muscle cramps on exertion", "Muscle cramps with exertion" ; oboInOwl:id "HP:0003710" ; a owl:Class ; rdfs:label "Exercise-induced muscle cramps" ; rdfs:subClassOf obo:HP_0003394 . obo:HP_0003712 obo:IAO_0000115 "Abnormal increase in muscle size and mass not due to training." ; oboInOwl:hasAlternativeId "HP:0009042" ; oboInOwl:hasDbXref "UMLS:C2265792" ; oboInOwl:hasExactSynonym "Hypertrophic muscles", "Increased skeletal muscle cells", "Muscle hypertrophy", "Muscular hypertrophy" ; oboInOwl:id "HP:0003712" ; a owl:Class ; rdfs:comment "Increased muscle bulk based on clinical observation. Myofiber hyperplasia and hypertrophy may contribute but this is not easily tested clinically." ; rdfs:label "Skeletal muscle hypertrophy" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0030236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003713 obo:IAO_0000115 "Abnormal cell death involving muscle fibers usually associated with break in, or absence of, muscle surface fiber membrane and resulting in irreversible damage to muscle fibers." ; oboInOwl:hasAlternativeId "HP:0003726" ; oboInOwl:hasDbXref "UMLS:C1850848" ; oboInOwl:hasExactSynonym "Muscle fibre necrosis" ; oboInOwl:id "HP:0003713" ; a owl:Class ; rdfs:label "Muscle fiber necrosis" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0008002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003715 obo:IAO_0000115 "Myofibrillar structural changes characterized by abnormal intracellular accumulation of the intermediate filament desmin and other proteins." ; oboInOwl:hasDbXref "MSH:C580316", "SNOMEDCT_US:699269005", "UMLS:C2678065" ; oboInOwl:hasExactSynonym "Myofibrillar changes" ; oboInOwl:id "HP:0003715" ; a owl:Class ; rdfs:comment "This feature is demonstrated by muscle biopsy." ; rdfs:label "Myofibrillar myopathy" ; rdfs:subClassOf obo:HP_0003198 . obo:HP_0003716 oboInOwl:hasDbXref "UMLS:C1837799" ; oboInOwl:hasExactSynonym "Generalised muscular appearance from birth" ; oboInOwl:id "HP:0003716" ; a owl:Class ; rdfs:label "Generalized muscular appearance from birth" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0003717 oboInOwl:hasDbXref "UMLS:C1859442" ; oboInOwl:hasExactSynonym "Minimal fat below the skin" ; oboInOwl:id "HP:0003717" ; a owl:Class ; rdfs:label "Minimal subcutaneous fat" ; rdfs:subClassOf obo:HP_0003758 . obo:HP_0003719 obo:IAO_0000115 "Percussion-induced, local prolonged contractions (mounding) in muscle persisting for several seconds." ; oboInOwl:hasDbXref "UMLS:C1853702" ; oboInOwl:id "HP:0003719" ; a owl:Class ; rdfs:comment "Transient swelling of muscle induced by percussion (e.g., tapping on muscle with a reflex hammer)." ; rdfs:label "Muscle mounding" ; rdfs:subClassOf obo:HP_0010548 . obo:HP_0003720 obo:IAO_0000115 "Hypertrophy (increase in size) of muscle tissue in a generalized (not localized) distribution." ; oboInOwl:hasDbXref "UMLS:C3805639" ; oboInOwl:hasExactSynonym "Generalised increase in muscle cell size", "Generalised muscle hypertrophy", "Generalized increase in muscle cell size" ; oboInOwl:id "HP:0003720" ; a owl:Class ; rdfs:label "Generalized muscle hypertrophy" ; rdfs:subClassOf obo:HP_0003712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0003722 obo:IAO_0000115 "Weakness of the muscles involved in neck flexion (sternocleidomastoid, longus capitus, longus colli, and scalenus anterior)." ; oboInOwl:hasAlternativeId "HP:0000469" ; oboInOwl:hasDbXref "UMLS:C1843637" ; oboInOwl:hasExactSynonym "Neck flexion weakness", "Neck flexor muscle weakness" ; oboInOwl:id "HP:0003722" ; a owl:Class ; rdfs:label "Neck flexor weakness" ; rdfs:subClassOf obo:HP_0000467 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000366 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003724 obo:IAO_0000115 "Amyotrophy affecting the muscles of the shoulder girdle." ; oboInOwl:hasDbXref "UMLS:C1847766" ; oboInOwl:hasExactSynonym "Shoulder girdle atrophy", "Shoulder girdle muscle wasting", "Shoulder-girdle muscle atrophy" ; oboInOwl:id "HP:0003724" ; a owl:Class ; rdfs:label "Shoulder girdle muscle atrophy" ; rdfs:subClassOf obo:HP_0003797 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004471 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003725 oboInOwl:hasDbXref "UMLS:C1850656" ; oboInOwl:id "HP:0003725" ; a owl:Class ; rdfs:label "Firm muscles" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0003729 oboInOwl:hasDbXref "UMLS:C3806660" ; oboInOwl:id "HP:0003729" ; a owl:Class ; rdfs:label "Enteroviral dermatomyositis syndrome" ; rdfs:subClassOf obo:HP_0002743 . obo:HP_0003730 obo:IAO_0000115 "Spontaneous, repetitive electrical activity demonstrated by electromyography (EMG)." ; oboInOwl:hasDbXref "UMLS:C4020837", "UMLS:C4025576" ; oboInOwl:hasRelatedSynonym "EMG: spontaneous, repetitive electrical activity" ; oboInOwl:id "HP:0003730" ; a owl:Class ; rdfs:comment "This is a characteristic abnormality seen in the myotonias and periodic paralyses." ; rdfs:label "EMG: myotonic runs" ; rdfs:subClassOf obo:HP_0002486, obo:HP_0003457 . obo:HP_0003731 obo:IAO_0000115 "Weakness of the quadriceps muscle (that is, of the muscle fasciculus of quadriceps femoris)." ; oboInOwl:hasDbXref "SNOMEDCT_US:300948004", "UMLS:C0577655" ; oboInOwl:hasExactSynonym "Quadriceps weakness" ; oboInOwl:id "HP:0003731" ; a owl:Class ; rdfs:label "Quadriceps muscle weakness" ; rdfs:subClassOf obo:HP_0008994 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003733 obo:IAO_0000115 "Muscle hypertrophy affecting the thighs." ; oboInOwl:hasDbXref "UMLS:C1846674" ; oboInOwl:hasExactSynonym "Increased thigh size" ; oboInOwl:id "HP:0003733" ; a owl:Class ; rdfs:comment "Proximal lower limb hypertrophy" ; rdfs:label "Thigh hypertrophy" ; rdfs:subClassOf obo:HP_0008968 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003736 obo:IAO_0000115 "The lysosomal-vacuolar pathway has a role in the controlled intracellular digestion of macromolecules such as protein complexes and organelles. This feature refers to the presence of an abnormally increased number of autophagic vacuoles in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C0544966" ; oboInOwl:id "HP:0003736" ; a owl:Class ; rdfs:label "Autophagic vacuoles" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003737 obo:IAO_0000115 "A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers." ; oboInOwl:hasAlternativeId "HP:0008960" ; oboInOwl:hasDbXref "MSH:D017240", "SNOMEDCT_US:16851005", "UMLS:C0162670" ; oboInOwl:id "HP:0003737" ; a owl:Class ; rdfs:comment "This is a bundled term that should not be used for future annotations." ; rdfs:label "Mitochondrial myopathy" ; rdfs:subClassOf obo:HP_0003800 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003198 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003738 obo:IAO_0000115 "The occurrence of an unusually high amount of muscle pain following exercise." ; oboInOwl:hasDbXref "UMLS:C1850830" ; oboInOwl:hasExactSynonym "Exercise-induced muscle pain", "Muscle pain on exercise", "Muscle pain with exercise", "Muscle pain, exercise-induced" ; oboInOwl:id "HP:0003738" ; a owl:Class ; rdfs:label "Exercise-induced myalgia" ; rdfs:subClassOf obo:HP_0003326 . obo:HP_0003739 oboInOwl:hasAlternativeId "HP:0006963" ; oboInOwl:hasDbXref "UMLS:C3806442" ; oboInOwl:id "HP:0003739" ; a owl:Class ; rdfs:label "Myoclonic spasms" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0003740 obo:IAO_0000115 "Myotonia that occurs after a period of rest and decreases with continuing exercise." ; oboInOwl:hasDbXref "UMLS:C4025575" ; oboInOwl:id "HP:0003740" ; a owl:Class ; rdfs:label "Myotonia with warm-up phenomenon" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0003741 oboInOwl:hasAlternativeId "HP:0003793" ; oboInOwl:hasDbXref "SNOMEDCT_US:240059009", "UMLS:C0699743" ; oboInOwl:hasExactSynonym "Muscular dystrophy, congenital" ; oboInOwl:id "HP:0003741" ; a owl:Class ; rdfs:label "Congenital muscular dystrophy" ; rdfs:subClassOf obo:HP_0003560 . obo:HP_0003743 obo:IAO_0000115 "A type of autosomal dominant inheritance involving a gene that exhibits anticipation, the increase in severity and/or an earlier age of onset in subsequent generations." ; oboInOwl:hasDbXref "MSH:D020132", "UMLS:C0600498" ; oboInOwl:hasExactSynonym "Autosomal dominant with genetic anticipation" ; oboInOwl:id "HP:0003743" ; a owl:Class ; rdfs:comment "This mode of inheritance is characteristic of trinucleotide and some other repeat disorders." ; rdfs:label "Genetic anticipation" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0003744 obo:IAO_0000115 "A type of genetic anticipation observed predominantly upon transmission from affected males." ; oboInOwl:hasDbXref "UMLS:C1834002", "UMLS:C4025574" ; oboInOwl:hasRelatedSynonym "Paternal anticipation bias" ; oboInOwl:id "HP:0003744" ; a owl:Class ; rdfs:label "Genetic anticipation with paternal anticipation bias" ; rdfs:subClassOf obo:HP_0003743 . obo:HP_0003745 obo:IAO_0000115 "Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected." ; oboInOwl:hasAlternativeId "HP:0001420", "HP:0003747", "HP:0003769" ; oboInOwl:hasDbXref "UMLS:C1853237" ; oboInOwl:hasExactSynonym "Isolated cases", "No previous family history" ; oboInOwl:id "HP:0003745" ; a owl:Class ; rdfs:label "Sporadic" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0003749 obo:IAO_0000115 "Weakness of the muscles of the pelvic girdle (also known as the hip girdle), that is, lack of strength of the muscles around the pelvis." ; oboInOwl:hasAlternativeId "HP:0003692", "HP:0008999", "HP:0009036" ; oboInOwl:hasDbXref "SNOMEDCT_US:249941003", "UMLS:C0427064" ; oboInOwl:hasExactSynonym "Hip girdle muscle weakness", "Hip girdle weakness", "Hip-girdle muscle weakness", "Pelvic girdle weakness" ; oboInOwl:id "HP:0003749" ; a owl:Class ; rdfs:label "Pelvic girdle muscle weakness" ; rdfs:subClassOf obo:HP_0003325 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001497 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003750 obo:IAO_0000115 "An abnormal, increased fatiguability of the musculature." ; oboInOwl:hasDbXref "MSH:D018763", "SNOMEDCT_US:80449002", "UMLS:C0242979", "UMLS:C4025573" ; oboInOwl:hasRelatedSynonym "Muscle fatigue" ; oboInOwl:id "HP:0003750" ; a owl:Class ; rdfs:label "Increased muscle fatiguability" ; rdfs:subClassOf obo:HP_0011804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001816 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003752 obo:IAO_0000115 "Recurrent episodes of muscle flaccidity, a type of paralysis in which a muscle becomes soft and yields to passive stretching." ; oboInOwl:hasDbXref "UMLS:C4025572" ; oboInOwl:id "HP:0003752" ; a owl:Class ; rdfs:label "Episodic flaccid weakness" ; rdfs:subClassOf obo:HP_0010547 . obo:HP_0003755 obo:IAO_0000115 "The presence of abnormal muscle fiber size such that type 1 fibers are smaller than type 2 fibers." ; oboInOwl:hasDbXref "UMLS:C4025571" ; oboInOwl:hasExactSynonym "Type 1 fibres relatively smaller than type 2 fibres" ; oboInOwl:id "HP:0003755" ; a owl:Class ; rdfs:comment "This feature can only be observed on muscle biopsy." ; rdfs:label "Type 1 fibers relatively smaller than type 2 fibers" ; rdfs:subClassOf obo:HP_0012084 . obo:HP_0003756 oboInOwl:hasDbXref "SNOMEDCT_US:75047002", "UMLS:C1533847" ; oboInOwl:id "HP:0003756" ; a owl:Class ; rdfs:label "Skeletal myopathy" ; rdfs:subClassOf obo:HP_0003198 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003198 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003758 obo:IAO_0000115 "A reduced amount of fat tissue in the lowest layer of the integument. This feature can be appreciated by a reduced skinfold thickness." ; oboInOwl:hasAlternativeId "HP:0001002", "HP:0007409" ; oboInOwl:hasDbXref "SNOMEDCT_US:248316006", "UMLS:C0424631", "UMLS:C1857657" ; oboInOwl:hasExactSynonym "Decreased subcutaneous adipose tissue", "Decreased subcutaneous fat", "Reduced fat tissue below the skin", "Reduced subcutaneous fat", "Scanty adipose tissue" ; oboInOwl:id "HP:0003758" ; a owl:Class ; rdfs:label "Reduced subcutaneous adipose tissue" ; rdfs:subClassOf obo:HP_0001001, obo:HP_0040063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002190 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003759 obo:IAO_0000115 "Congenital underdevelopment of lymph vessels." ; oboInOwl:hasDbXref "UMLS:C4025570" ; oboInOwl:hasExactSynonym "Underdeveloped lymphatic vessels" ; oboInOwl:id "HP:0003759" ; a owl:Class ; rdfs:comment "This feature can be demonstrated by lymphography." ; rdfs:label "Hypoplasia of lymphatic vessels" ; rdfs:subClassOf obo:HP_0100766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003760 obo:IAO_0000115 "Mechanical percussion (i.e., striking a muscle with a reflex hammer) leads to spreading waves of muscle contractions that begin proximally and spread laterally across the muscle." ; oboInOwl:hasDbXref "UMLS:C4280804" ; oboInOwl:id "HP:0003760" ; a owl:Class ; rdfs:label "Percussion-induced rapid rolling muscle contractions" ; rdfs:subClassOf obo:HP_0010548 . obo:HP_0003761 obo:IAO_0000115 "Formation of calcium deposits in any soft tissue." ; oboInOwl:hasDbXref "MSH:D002114", "SNOMEDCT_US:6595006", "UMLS:C0006663" ; oboInOwl:hasExactSynonym "Calcium buildup in soft tissues of body" ; oboInOwl:id "HP:0003761" ; a owl:Class ; rdfs:label "Calcinosis" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0003762 obo:IAO_0000115 "A malformation of the uterus in which the uterus is present as a paired organ as a result of the failure of fusion of the mullerian ducts during embryogenesis." ; oboInOwl:hasDbXref "SNOMEDCT_US:15545001", "SNOMEDCT_US:22504001", "UMLS:C0152240", "UMLS:C0266393" ; oboInOwl:hasRelatedSynonym "Double uterus" ; oboInOwl:id "HP:0003762" ; a owl:Class ; rdfs:label "Uterus didelphys" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0003763 obo:IAO_0000115 "Bruxism is characterized by the grinding of the teeth including the clenching of the jaw and typically occur during sleep, but also can occur while the affected individual is awake." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "MSH:D002012", "SNOMEDCT_US:191983006", "SNOMEDCT_US:90207007", "UMLS:C0006325" ; oboInOwl:hasExactSynonym "Teeth grinding" ; oboInOwl:id "HP:0003763" ; a owl:Class ; rdfs:label "Bruxism" ; rdfs:subClassOf obo:HP_5200017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003764 obo:IAO_0000115 "A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin." ; oboInOwl:hasDbXref "MSH:D009506", "MSH:D009508", "SNOMEDCT_US:21119008", "SNOMEDCT_US:400096001", "SNOMEDCT_US:51697005", "UMLS:C0027960", "UMLS:C0027962" ; oboInOwl:hasExactSynonym "Mole", "Naevus" ; oboInOwl:hasRelatedSynonym "Naevi", "Nevi" ; oboInOwl:id "HP:0003764" ; a owl:Class ; rdfs:comment "The word Nevus derives from the Latin word Knee-vus meaning birthmark or mole." ; rdfs:label "Nevus" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0003765 obo:IAO_0000115 "A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales)." ; oboInOwl:hasDbXref "MSH:D011565", "SNOMEDCT_US:9014002", "UMLS:C0033860" ; oboInOwl:hasExactSynonym "Psoriasis" ; oboInOwl:id "HP:0003765" ; a owl:Class ; rdfs:comment "The label Psoriaform dermatitis is used to emphasize that this term is meant to describe the morhpological abnormality of the skin and not all of the manifestations of the disease psoriasis (which can also include itching and nail pitsand other manifestations)." ; rdfs:label "Psoriasiform dermatitis" ; rdfs:subClassOf obo:HP_0011123 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_675 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003768 obo:IAO_0000115 "Episodes of muscle weakness." ; oboInOwl:hasDbXref "SNOMEDCT_US:198030008", "UMLS:C1279412" ; oboInOwl:hasExactSynonym "Episodic paralysis" ; oboInOwl:id "HP:0003768" ; a owl:Class ; rdfs:label "Periodic paralysis" ; rdfs:subClassOf obo:HP_0003470 . obo:HP_0003771 obo:IAO_0000115 "Pulp calcifications may appear as punctate calcifications, irregular, roughly spherical mineralized masses in any part of the pulp. It may occur isolated or associated to calcifications elsewhere such as the carotid arteries and kidneys. The diagnosis pulp calcifications can be established using radiological studies." ; oboInOwl:hasDbXref "MSH:D003784", "SNOMEDCT_US:57602001", "UMLS:C1527284", "UMLS:C4280259", "UMLS:C4280546" ; oboInOwl:hasExactSynonym "Pulp calcifications", "Pulp denticles", "Pulp stones", "Pulpoliths" ; oboInOwl:hasNarrowSynonym "False denticles", "False pulp stones", "True denticles", "True pulp stones" ; oboInOwl:id "HP:0003771" ; a owl:Class ; rdfs:label "Pulp calcification" ; rdfs:subClassOf obo:HP_0006479 . obo:HP_0003774 obo:IAO_0000115 "A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine." ; oboInOwl:hasAlternativeId "HP:0000101", "HP:0004720", "HP:0004725", "HP:0004733", "HP:0004738", "HP:0005570" ; oboInOwl:hasDbXref "SNOMEDCT_US:433146000", "UMLS:C2316810" ; oboInOwl:hasExactSynonym "Chronic renal failure", "End stage renal disease", "End stage renal failure", "End-stage renal disease", "End-stage renal failure", "Stage 5 chronic kidney disease" ; oboInOwl:hasRelatedSynonym "Renal failure, endstage" ; oboInOwl:id "HP:0003774" ; a owl:Class ; rdfs:comment "Equivalent with the National Kidney Foundation's definition of stage 5 chronic kidney disease." ; rdfs:label "Stage 5 chronic kidney disease" ; rdfs:subClassOf obo:HP_0012622 . obo:HP_0003777 obo:IAO_0000115 "Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope." ; oboInOwl:hasDbXref "MSH:C562485", "SNOMEDCT_US:17170005", "UMLS:C0263491" ; oboInOwl:hasExactSynonym "Flattened and twisted hair" ; oboInOwl:id "HP:0003777" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pili torti" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0003778 oboInOwl:hasAlternativeId "HP:0005447" ; oboInOwl:hasBroadSynonym "Decreased size of mandibular ramus" ; oboInOwl:hasDbXref "UMLS:C1841648", "UMLS:C4280545" ; oboInOwl:hasExactSynonym "Short body and ramus of mandible", "Short mandibular ramus", "Underdeveloped mandibular rami" ; oboInOwl:hasNarrowSynonym "Decreased height of mandibular ramus" ; oboInOwl:id "HP:0003778" ; a owl:Class ; rdfs:label "Short mandibular rami" ; rdfs:subClassOf obo:HP_0000347, obo:HP_3000003 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003779 oboInOwl:hasDbXref "UMLS:C1844509" ; oboInOwl:hasExactSynonym "Deep antegonial notch of mandible", "Large antegonial notch of mandible" ; oboInOwl:id "HP:0003779" ; a owl:Class ; rdfs:label "Antegonial notching of mandible" ; rdfs:subClassOf obo:HP_0010753 . obo:HP_0003781 obo:IAO_0000115 "Excessive production of saliva." ; oboInOwl:hasDbXref "MSH:D012798", "SNOMEDCT_US:275295002", "SNOMEDCT_US:53827007", "SNOMEDCT_US:62718007", "UMLS:C0013132", "UMLS:C0037036" ; oboInOwl:hasExactSynonym "Excessive production of saliva", "Excessive salivation", "Hypersalivation", "Mouth watering", "Oversalivation", "Ptyalism", "Watery mouth" ; oboInOwl:id "HP:0003781" ; a owl:Class ; rdfs:label "Excessive salivation" ; rdfs:subClassOf obo:HP_0100755 . obo:HP_0003782 obo:IAO_0000115 "A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more)." ; oboInOwl:hasDbXref "UMLS:C4025569" ; oboInOwl:id "HP:0003782" ; a owl:Class ; rdfs:label "Eunuchoid habitus" ; rdfs:subClassOf obo:HP_0004325 . obo:HP_0003783 obo:IAO_0100001 "HP:0008796" ; oboInOwl:id "HP:0003783" ; a owl:Class ; rdfs:label "obsolete Externally rotated/abducted legs" ; owl:deprecated true . obo:HP_0003784 oboInOwl:hasDbXref "UMLS:C1970463" ; oboInOwl:id "HP:0003784" ; a owl:Class ; rdfs:label "Type 1 collagen overmodification" ; rdfs:subClassOf obo:HP_0011862 . obo:HP_0003785 obo:IAO_0000115 "Decreased concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine." ; oboInOwl:hasDbXref "UMLS:C4280803" ; oboInOwl:id "HP:0003785" ; a owl:Class ; rdfs:label "Decreased CSF homovanillic acid concentration" ; rdfs:subClassOf obo:HP_0034200 . obo:HP_0003787 obo:IAO_0000115 "Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in type 1 and type 2 muscle fibers." ; oboInOwl:hasDbXref "UMLS:C4025568" ; oboInOwl:hasExactSynonym "Type 1 and type 2 muscle fibre minicore regions" ; oboInOwl:id "HP:0003787" ; a owl:Class ; rdfs:label "Type 1 and type 2 muscle fiber minicore regions" ; rdfs:subClassOf obo:HP_0003789 . obo:HP_0003789 obo:IAO_0000115 "Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in muscle fibers." ; oboInOwl:hasAlternativeId "HP:0003804" ; oboInOwl:hasDbXref "MSH:C564969", "UMLS:C1850674" ; oboInOwl:id "HP:0003789" ; a owl:Class ; rdfs:label "Minicore myopathy" ; rdfs:subClassOf obo:HP_0003198 . obo:HP_0003791 oboInOwl:hasDbXref "UMLS:C1853934" ; oboInOwl:id "HP:0003791" ; a owl:Class ; rdfs:label "Deposits immunoreactive to beta-amyloid protein" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003795 obo:IAO_0000115 "Developmental hypoplasia (shortening) of middle phalanx of toe." ; oboInOwl:hasDbXref "UMLS:C4021723" ; oboInOwl:hasExactSynonym "Short middle bones (feet)", "Short middle phalanges of toes" ; oboInOwl:id "HP:0003795" ; a owl:Class ; rdfs:label "Short middle phalanx of toe" ; rdfs:subClassOf obo:HP_0001831, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003796 obo:IAO_0000115 "Irregularity of the iliac crest, which is the superior border of the wing of the ilium." ; oboInOwl:hasDbXref "UMLS:C1855180" ; oboInOwl:id "HP:0003796" ; a owl:Class ; rdfs:label "Irregular iliac crest" ; rdfs:subClassOf obo:HP_0002867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003797 obo:IAO_0000115 "Muscular atrophy affecting the muscles of the limb girdle." ; oboInOwl:hasBroadSynonym "Limb-girdle myopathy" ; oboInOwl:hasDbXref "UMLS:C1404521", "UMLS:C1842552" ; oboInOwl:hasExactSynonym "Wasting of limb-girdle muscle" ; oboInOwl:id "HP:0003797" ; a owl:Class ; rdfs:label "Limb-girdle muscle atrophy" ; rdfs:subClassOf obo:HP_0003202, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003798 obo:IAO_0000115 "Nemaline rods are abnormal bodies that can occur in skeletal muscle fibers. The rods can be observed on histological analysis of muscle biopsy tissue or upon electron microscopy, where they appear either as extensions of sarcomeric Z-lines, in random array without obvious attachment to Z-lines (often in areas devoid of sarcomeres) or in large clusters localized at the sarcolemma or intermyofibrillar spaces." ; oboInOwl:hasDbXref "UMLS:C3808039" ; oboInOwl:hasExactSynonym "Nemaline rods" ; oboInOwl:id "HP:0003798" ; a owl:Class ; rdfs:comment """This finding can be demonstrated by muscle biopsy, which shows nemaline bodies (rods) on Gomori trichrome staining. Rod bodies characteristically stain red with MGT. The rods are delicate and accumulate subsarcolemmaly. They stain negative with ATPase, NADH and SDH as they lack myosin and mitochondria. Rods are characteristic of nemaline myopathy but also seen in central core disease and various other diseases which include neurogenic disorders (amyotrophic lateral sclerosis, spinal muscular atrophy, undefined), inflammatory myopathies (dermatomyositis, polymyositis, periarteritis nodosa), metabolic myopathy (mitochondrial myopathy), muscular dystrophy (LGMD) and some undefined myopathies (Liouet al; Diagnostic role of nemaline rod in neuromuscular disease. Acta Neurol Sinica 1992;1: 218-23).""" ; rdfs:label "Nemaline bodies" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0003799 oboInOwl:hasAlternativeId "HP:0005742", "HP:0005843" ; oboInOwl:hasDbXref "UMLS:C1868549" ; oboInOwl:hasExactSynonym "Marked delay in bone age", "Marked retardation in skeletal maturation", "Markedly retarded bone age" ; oboInOwl:id "HP:0003799" ; a owl:Class ; rdfs:label "Marked delay in bone age" ; rdfs:subClassOf obo:HP_0002750 . obo:HP_0003800 oboInOwl:hasDbXref "UMLS:C4025566" ; oboInOwl:id "HP:0003800" ; a owl:Class ; rdfs:label "Muscle abnormality related to mitochondrial dysfunction" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0003803 obo:IAO_0000115 "An abnormal predominance of type I muscle fibers (in general, this feature can only be observed on muscle biopsy)." ; oboInOwl:hasAlternativeId "HP:0003721", "HP:0003807" ; oboInOwl:hasDbXref "UMLS:C1854387" ; oboInOwl:hasExactSynonym "Type 1 muscle fibre predominance", "Type I muscle fiber predominance", "Type I muscle fibre predominance" ; oboInOwl:id "HP:0003803" ; a owl:Class ; rdfs:comment "This finding is demonstrated by muscle biopsy." ; rdfs:label "Type 1 muscle fiber predominance" ; rdfs:subClassOf obo:HP_0033684 . obo:HP_0003805 obo:IAO_0000115 "Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions." ; oboInOwl:hasAlternativeId "HP:0009029" ; oboInOwl:hasDbXref "UMLS:C1853932" ; oboInOwl:hasExactSynonym "Rimmed vacuoles on biopsy" ; oboInOwl:id "HP:0003805" ; a owl:Class ; rdfs:comment "Rimmed vacuoles are characteristic for inclusion-bosy myositis, but are also seen an a number of other diseases. This term implies that rimmed vacuoles are found histologically. In some cases, the majority of muscle fibers are involved, but in others, rimmed vacuoles can be found in only a minority of fibers." ; rdfs:label "Rimmed vacuoles" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0003808 oboInOwl:hasDbXref "UMLS:C0852413" ; oboInOwl:hasExactSynonym "Abnormal muscle tone" ; oboInOwl:id "HP:0003808" ; a owl:Class ; rdfs:label "Abnormal muscle tone" ; rdfs:subClassOf obo:HP_0011804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001439 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003809 obo:IAO_0000115 "An abnormally reduced amount of adipose tissue in the thoracic cavity." ; oboInOwl:hasDbXref "UMLS:C1837797" ; oboInOwl:id "HP:0003809" ; a owl:Class ; rdfs:label "Reduced intrathoracic adipose tissue" ; rdfs:subClassOf obo:HP_0040063 . obo:HP_0003810 oboInOwl:hasAlternativeId "HP:0003728" ; oboInOwl:hasDbXref "UMLS:C4025565" ; oboInOwl:id "HP:0003810" ; a owl:Class ; rdfs:label "Late-onset distal muscle weakness" ; rdfs:subClassOf obo:HP_0002460 . obo:HP_0003811 obo:IAO_0000115 "Death within the first 28 days of life." ; oboInOwl:hasAlternativeId "HP:0003820", "HP:0003824" ; oboInOwl:hasDbXref "MSH:D066087", "SNOMEDCT_US:276506001", "UMLS:C0410916" ; oboInOwl:hasExactSynonym "Neonatal lethal" ; oboInOwl:id "HP:0003811" ; a owl:Class ; rdfs:label "Neonatal death" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0003812 obo:IAO_0000115 "A variability of phenotypic features." ; oboInOwl:hasAlternativeId "HP:0003813", "HP:0003815", "HP:0003821", "HP:0003822" ; oboInOwl:hasDbXref "UMLS:C1837514", "UMLS:C1839039", "UMLS:C1850667", "UMLS:C1866210" ; oboInOwl:hasExactSynonym "Clinical heterogeneity", "Highly variable clinical phenotype", "Highly variable phenotype", "Highly variable phenotype and severity", "Highly variable phenotype, even within families", "Variable phenotype", "Variable phenotypic severity" ; oboInOwl:id "HP:0003812" ; a owl:Class ; rdfs:comment "This term can be applied to disease entities but not to individuals. It may be made obsolete in future versions of the HPO." ; rdfs:label "Phenotypic variability" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0003819 obo:IAO_0000115 "Death in during childhood, defined here as between the ages of 2 and 10 years." ; oboInOwl:hasAlternativeId "HP:0001432", "HP:0004149" ; oboInOwl:hasDbXref "UMLS:C1843392" ; oboInOwl:hasExactSynonym "Death in childhood" ; oboInOwl:id "HP:0003819" ; a owl:Class ; rdfs:comment """previous def was: 'has part' some (premature and ('inheres in' some death) and ('has modifier' some abnormal))""" ; rdfs:label "Death in childhood" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0003826 obo:IAO_0000115 "Death of the fetus in utero after at least 22 weeks of gestation." ; oboInOwl:hasAlternativeId "HP:0001624", "HP:0001625" ; oboInOwl:hasDbXref "MSH:D005313", "MSH:D050497", "SNOMEDCT_US:237364002", "SNOMEDCT_US:276507005", "UMLS:C0015927", "UMLS:C0595939" ; oboInOwl:hasExactSynonym "Late fetal death", "Late foetal death", "Stillbirth", "Stillborn" ; oboInOwl:hasRelatedSynonym "Fetal death", "Fetal demise", "Foetal death", "Foetal demise" ; oboInOwl:id "HP:0003826" ; a owl:Class ; rdfs:comment "The age at which fetal demise is legally classified asa a miscarriage varies between countries with the US being 20 gestational weeks and the UK being 24 gestational weeks. The HPO chooses the average of these age ranges." ; rdfs:label "Stillbirth" ; rdfs:subClassOf obo:HP_0034241 . obo:HP_0003828 obo:IAO_0000115 "A variable severity of phenotypic features." ; oboInOwl:hasAlternativeId "HP:0003814", "HP:0003825" ; oboInOwl:hasDbXref "UMLS:C1861403", "UMLS:C1866862" ; oboInOwl:hasExactSynonym "Variable severity" ; oboInOwl:hasRelatedSynonym "Highly variable severity" ; oboInOwl:id "HP:0003828" ; a owl:Class ; rdfs:comment "This term can be applied to disease entities but not to individuals. It may be made obsolete in future versions of the HPO." ; rdfs:label "Variable expressivity" ; rdfs:subClassOf obo:HP_0003812 . obo:HP_0003829 obo:IAO_0000115 "Description of conditions in which not all individuals with a given genotype exhibit the disease. Penetrance is the proportion that develop disease given a lifespan of 80 years." ; oboInOwl:hasAlternativeId "HP:0003830" ; oboInOwl:hasDbXref "UMLS:C1836598" ; oboInOwl:hasExactSynonym "Incomplete penetrance", "Reduced penetrance" ; oboInOwl:id "HP:0003829" ; a owl:Class ; rdfs:comment "For example, Van der Woude syndrome due to IRF6 causes cleft lip and/or palate with penetrance estimated at 80%, and C9orf72 causes frontotemporal dementia and/or amyotrophic lateral sclerosis with approximately 50% penetrance." ; rdfs:label "Typified by incomplete penetrance" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0003831 obo:IAO_0000115 "Description of conditions in which age of onset is typically later in life and in which penetrance is dependent on the age of the subject." ; oboInOwl:hasDbXref "UMLS:C1835978" ; oboInOwl:hasExactSynonym "Age dependent penetrance", "Age-dependent penetrance", "Typified by age-related penetrance" ; oboInOwl:id "HP:0003831" ; a owl:Class ; rdfs:label "Typified by age-related disease onset" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0003832 oboInOwl:hasDbXref "UMLS:C4025564" ; oboInOwl:id "HP:0003832" ; a owl:Class ; rdfs:label "Abnormality of the tibial plateaux" ; rdfs:subClassOf obo:HP_0002992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003833 oboInOwl:hasDbXref "UMLS:C4025563" ; oboInOwl:id "HP:0003833" ; a owl:Class ; rdfs:label "Laterally deficient tibial plateaux" ; rdfs:subClassOf obo:HP_0003832 . obo:HP_0003834 obo:IAO_0000115 "A displacement or misalignment of the humerus with respect to the other bones of the should joint. Note that a subluxation is a partial dislocation." ; oboInOwl:hasDbXref "MSH:D012783", "SNOMEDCT_US:125615005", "SNOMEDCT_US:417076003", "UMLS:C0037005" ; oboInOwl:hasExactSynonym "Shoulder dislocation" ; oboInOwl:id "HP:0003834" ; a owl:Class ; rdfs:label "Shoulder dislocation" ; rdfs:subClassOf obo:HP_0003043, obo:HP_0030310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003835 obo:IAO_0000115 "A partial dislocation of the shoulder joint." ; oboInOwl:hasDbXref "SNOMEDCT_US:263051004", "UMLS:C0434744" ; oboInOwl:hasExactSynonym "Partial shoulder dislocation" ; oboInOwl:id "HP:0003835" ; a owl:Class ; rdfs:label "Shoulder subluxation" ; rdfs:subClassOf obo:HP_0032153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003836 oboInOwl:hasDbXref "UMLS:C4025562" ; oboInOwl:id "HP:0003836" ; a owl:Class ; rdfs:label "Stippled calcification of the shoulder" ; rdfs:subClassOf obo:HP_0003043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0003837 obo:IAO_0000115 "Formation of calcified tissue in the soft tissues surrounding the shoulder." ; oboInOwl:hasDbXref "UMLS:C4025561" ; oboInOwl:hasRelatedSynonym "Calcification of the soft-tissue around the shoulders" ; oboInOwl:id "HP:0003837" ; a owl:Class ; rdfs:label "Soft-tissue ossification around the shoulders" ; rdfs:subClassOf obo:HP_0011986 . obo:HP_0003839 oboInOwl:hasAlternativeId "HP:0003845" ; oboInOwl:hasDbXref "UMLS:C4021722" ; oboInOwl:hasExactSynonym "Abnormal shape of end part of upper limb long bones", "Abnormality involving the epiphyses of the upper limbs", "Epihyseal plate abnormality of the upper limbs" ; oboInOwl:id "HP:0003839" ; a owl:Class ; rdfs:label "Abnormality of upper limb epiphysis morphology" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0006505 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003840 obo:IAO_0000115 "A delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs." ; oboInOwl:hasDbXref "UMLS:C4025560", "UMLS:C4280544" ; oboInOwl:hasRelatedSynonym "Delayed maturation fo the end part of the upper limb bone" ; oboInOwl:id "HP:0003840" ; a owl:Class ; rdfs:label "Delayed upper limb epiphyseal ossification" ; rdfs:subClassOf obo:HP_0002663, obo:HP_0003839 . obo:HP_0003841 oboInOwl:hasDbXref "UMLS:C4025559" ; oboInOwl:hasExactSynonym "Fragmented end part of upper limb bones" ; oboInOwl:id "HP:0003841" ; a owl:Class ; rdfs:label "Fragmented epiphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0100168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040047 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003842 oboInOwl:hasDbXref "UMLS:C4025558" ; oboInOwl:hasExactSynonym "Irregular end part of upper limb bones" ; oboInOwl:id "HP:0003842" ; a owl:Class ; rdfs:label "Irregular epiphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0010582 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003843 oboInOwl:hasDbXref "UMLS:C4025557" ; oboInOwl:hasExactSynonym "Round end part of upper limb bones" ; oboInOwl:id "HP:0003843" ; a owl:Class ; rdfs:label "Round epiphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003844 oboInOwl:hasDbXref "UMLS:C4025556" ; oboInOwl:hasExactSynonym "Small end part of upper limb bones" ; oboInOwl:id "HP:0003844" ; a owl:Class ; rdfs:label "Small epiphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0010585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003846 oboInOwl:hasDbXref "UMLS:C4020913" ; oboInOwl:hasExactSynonym "Broad epiphyseal plates of the upper limbs", "Broad growth plates of upper limbs" ; oboInOwl:id "HP:0003846" ; a owl:Class ; rdfs:label "Wide epiphyseal plates of the upper limbs" ; rdfs:subClassOf obo:HP_0003839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002516 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003848 oboInOwl:hasDbXref "UMLS:C4025555" ; oboInOwl:hasExactSynonym "Cupped wide portion of the upper limb bone" ; oboInOwl:id "HP:0003848" ; a owl:Class ; rdfs:label "Cupped metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003021, obo:HP_0009809 . obo:HP_0003849 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the arm." ; oboInOwl:hasDbXref "UMLS:C4021721" ; oboInOwl:hasExactSynonym "Flared metaphyses of the upper limbs", "Flared wide portion of the upper limb bone" ; oboInOwl:id "HP:0003849" ; a owl:Class ; rdfs:label "Flared upper limb metaphysis" ; rdfs:subClassOf obo:HP_0003015, obo:HP_0003856 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003015 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003850 oboInOwl:hasDbXref "UMLS:C4021720" ; oboInOwl:hasExactSynonym "Irregular metaphyses of the upper limbs", "Irregular wide portion of upper limb bones" ; oboInOwl:id "HP:0003850" ; a owl:Class ; rdfs:label "Upper-limb metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003025, obo:HP_0009809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003851 oboInOwl:hasDbXref "UMLS:C4025554" ; oboInOwl:id "HP:0003851" ; a owl:Class ; rdfs:label "Lytic defects in metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0009809 . obo:HP_0003852 oboInOwl:hasDbXref "UMLS:C4025553" ; oboInOwl:id "HP:0003852" ; a owl:Class ; rdfs:label "Normal density transverse bands in metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0009809 . obo:HP_0003853 oboInOwl:hasDbXref "UMLS:C4025552" ; oboInOwl:id "HP:0003853" ; a owl:Class ; rdfs:label "Sclerosis with transverse striations in metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003854 . obo:HP_0003854 oboInOwl:hasDbXref "UMLS:C4025551" ; oboInOwl:hasExactSynonym "Increased bone density in wide portion of the upper limb bones" ; oboInOwl:id "HP:0003854" ; a owl:Class ; rdfs:label "Sclerosis of metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0009809 . obo:HP_0003855 oboInOwl:hasDbXref "UMLS:C4025550" ; oboInOwl:hasExactSynonym "Spurred wide portion of upper limb bone" ; oboInOwl:id "HP:0003855" ; a owl:Class ; rdfs:label "Spurred metaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0005054, obo:HP_0009809 . obo:HP_0003856 obo:IAO_0000115 "Increased width (breadth) of metaphyses of the arms." ; oboInOwl:hasDbXref "UMLS:C4021719" ; oboInOwl:hasExactSynonym "Broad wide portion of upper limb bone", "Wide/broad metaphyses of the upper limbs" ; oboInOwl:id "HP:0003856" ; a owl:Class ; rdfs:label "Upper limb metaphyseal widening" ; rdfs:subClassOf obo:HP_0003016, obo:HP_0009809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003858 oboInOwl:hasDbXref "UMLS:C4025549" ; oboInOwl:id "HP:0003858" ; a owl:Class ; rdfs:label "Cortical diaphyseal irregularity of the upper limbs" ; rdfs:subClassOf obo:HP_0009808 . obo:HP_0003859 oboInOwl:hasDbXref "UMLS:C4025548" ; oboInOwl:id "HP:0003859" ; a owl:Class ; rdfs:label "Cortical diaphyseal thickening of the upper limbs" ; rdfs:subClassOf obo:HP_0009808 . obo:HP_0003860 obo:IAO_0000115 "An elevation in bone density in one or more diaphyses of the arms. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4025547" ; oboInOwl:hasExactSynonym "Increased bone density in central part of long bone of upper limbs" ; oboInOwl:id "HP:0003860" ; a owl:Class ; rdfs:label "Diaphyseal sclerosis of the upper limbs" ; rdfs:subClassOf obo:HP_0003034, obo:HP_0009808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012475 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003861 oboInOwl:hasDbXref "UMLS:C4021718" ; oboInOwl:hasExactSynonym "Broad shaft of long bone of the upper limbs", "Wide diaphyses of the upper limbs", "Wide shaft of long bone of the upper limbs" ; oboInOwl:id "HP:0003861" ; a owl:Class ; rdfs:label "Broad diaphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0009808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003862 obo:IAO_0000115 "Missing humerus bone associated with congenital failure of development." ; oboInOwl:hasDbXref "UMLS:C2678399" ; oboInOwl:hasExactSynonym "Absent long bone in upper arm", "Aplasia of the humerus", "Aplastic humerus" ; oboInOwl:id "HP:0003862" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent humerus" ; rdfs:subClassOf obo:HP_0006507 . obo:HP_0003863 oboInOwl:hasDbXref "UMLS:C4025546" ; oboInOwl:hasExactSynonym "Angulated long bone in upper arm" ; oboInOwl:id "HP:0003863" ; a owl:Class ; rdfs:label "Angulated humerus" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003864 obo:IAO_0000115 "Clefting affecting the humerus." ; oboInOwl:hasDbXref "UMLS:C4025545" ; oboInOwl:hasExactSynonym "Notched long bone in upper arm" ; oboInOwl:id "HP:0003864" ; a owl:Class ; rdfs:label "Bifid humerus" ; rdfs:subClassOf obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003865 obo:IAO_0000115 "A bending or abnormal curvature of the humerus." ; oboInOwl:hasDbXref "UMLS:C1859460" ; oboInOwl:hasExactSynonym "Bowed long bone in upper arm", "Bowing of the humerus", "Humeral bowing" ; oboInOwl:id "HP:0003865" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bowed humerus" ; rdfs:subClassOf obo:HP_0006488, obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003866 oboInOwl:hasDbXref "UMLS:C4025544" ; oboInOwl:id "HP:0003866" ; a owl:Class ; rdfs:label "Coarse humeral trabeculae" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003867 oboInOwl:hasDbXref "UMLS:C4025543" ; oboInOwl:id "HP:0003867" ; a owl:Class ; rdfs:label "Humeral cortical irregularity" ; rdfs:subClassOf obo:HP_0005731, obo:HP_0010629 . obo:HP_0003868 oboInOwl:hasDbXref "UMLS:C4025542" ; oboInOwl:id "HP:0003868" ; a owl:Class ; rdfs:label "Humeral cortical thickening" ; rdfs:subClassOf obo:HP_0000935, obo:HP_0010629 . obo:HP_0003869 oboInOwl:hasDbXref "UMLS:C4025541" ; oboInOwl:id "HP:0003869" ; a owl:Class ; rdfs:label "Humeral cortical thinning" ; rdfs:subClassOf obo:HP_0002753, obo:HP_0010629 . obo:HP_0003870 oboInOwl:hasAlternativeId "HP:0003873" ; oboInOwl:hasDbXref "UMLS:C4025540" ; oboInOwl:hasExactSynonym "Crumpled long bone in upper arm" ; oboInOwl:id "HP:0003870" ; a owl:Class ; rdfs:label "Crumpled humerus" ; rdfs:subClassOf obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003871 oboInOwl:hasDbXref "UMLS:C4025539" ; oboInOwl:hasExactSynonym "Deformed long bone in upper arm" ; oboInOwl:id "HP:0003871" ; a owl:Class ; rdfs:label "Deformed humerus" ; rdfs:subClassOf obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003872 obo:IAO_0000115 "Presence of more than one exostosis originating in one or noth humerus bones. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." ; oboInOwl:hasDbXref "UMLS:C4025538" ; oboInOwl:id "HP:0003872" ; a owl:Class ; rdfs:label "Humeral exostoses" ; rdfs:subClassOf obo:HP_0002762, obo:HP_0031095 . obo:HP_0003874 oboInOwl:hasDbXref "UMLS:C4025537" ; oboInOwl:id "HP:0003874" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Humerus varus" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003875 obo:IAO_0000115 "Destruction of an area of humerus bone due to a disease process, such as cancer." ; oboInOwl:hasDbXref "UMLS:C4025536" ; oboInOwl:hasExactSynonym "Lytic defects of the humerus" ; oboInOwl:id "HP:0003875" ; a owl:Class ; rdfs:comment "Osteolytic defects can be observed by radiology studies such as an X-ray; however, the type of condition that is causing the lesion cannot be fully determined by the X-ray alone." ; rdfs:label "Humeral lytic defects" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003876 oboInOwl:hasDbXref "UMLS:C4025535" ; oboInOwl:id "HP:0003876" ; a owl:Class ; rdfs:label "Osteoporotic humerus" ; rdfs:subClassOf obo:HP_0003063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0003877 oboInOwl:hasDbXref "UMLS:C4025534" ; oboInOwl:hasExactSynonym "Humeral oval transradiancy" ; oboInOwl:id "HP:0003877" ; a owl:Class ; rdfs:label "Oval transradiancy of humerus" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003878 oboInOwl:hasDbXref "UMLS:C4025533" ; oboInOwl:id "HP:0003878" ; a owl:Class ; rdfs:label "Periosteal new bone of humerus" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0030314 . obo:HP_0003879 oboInOwl:hasDbXref "UMLS:C4025532" ; oboInOwl:hasExactSynonym "False joint (long bone in upper arm)" ; oboInOwl:id "HP:0003879" ; a owl:Class ; rdfs:label "Humeral pseudarthrosis" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003880 oboInOwl:hasDbXref "UMLS:C4021717" ; oboInOwl:hasExactSynonym "Humeral sclerotic foci" ; oboInOwl:id "HP:0003880" ; a owl:Class ; rdfs:label "Sclerotic foci of the humerus" ; rdfs:subClassOf obo:HP_0003881 . obo:HP_0003881 oboInOwl:hasDbXref "UMLS:C4021716" ; oboInOwl:hasExactSynonym "Increased bone density in long bone of upper arm", "Sclerosis of humerus" ; oboInOwl:id "HP:0003881" ; a owl:Class ; rdfs:label "Humeral sclerosis" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0006392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003882 obo:IAO_0000115 "Reduction in diameter of the humerus." ; oboInOwl:hasDbXref "UMLS:C4021851" ; oboInOwl:hasExactSynonym "Slender long bone of upper arm" ; oboInOwl:id "HP:0003882" ; a owl:Class ; rdfs:label "Slender humerus" ; rdfs:subClassOf obo:HP_0003100, obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003883 oboInOwl:hasDbXref "UMLS:C4025531" ; oboInOwl:hasExactSynonym "Tapered long bone of upper arm" ; oboInOwl:id "HP:0003883" ; a owl:Class ; rdfs:label "Tapered humerus" ; rdfs:subClassOf obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003884 oboInOwl:hasDbXref "UMLS:C4025530" ; oboInOwl:hasExactSynonym "Triangular long bone of upper arm" ; oboInOwl:id "HP:0003884" ; a owl:Class ; rdfs:label "Triangular humerus" ; rdfs:subClassOf obo:HP_0003063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003885 oboInOwl:hasDbXref "UMLS:C4025529" ; oboInOwl:id "HP:0003885" ; a owl:Class ; rdfs:label "Undermodeled humerus" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0003886 oboInOwl:hasDbXref "UMLS:C4021715" ; oboInOwl:hasExactSynonym "Broad humerus", "Wide long bone of upper arm" ; oboInOwl:id "HP:0003886" ; a owl:Class ; rdfs:label "Wide humerus" ; rdfs:subClassOf obo:HP_0005622, obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003887 oboInOwl:hasDbXref "UMLS:C4025528" ; oboInOwl:hasExactSynonym "Abnormal head of long bone in upper arm", "Abnormality of the humeral heads" ; oboInOwl:id "HP:0003887" ; a owl:Class ; rdfs:label "Abnormal humeral head morphology" ; rdfs:subClassOf obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003888 oboInOwl:hasDbXref "UMLS:C3808869" ; oboInOwl:hasExactSynonym "Flattended head of long bone in upper arm" ; oboInOwl:id "HP:0003888" ; a owl:Class ; rdfs:label "Flattened humeral heads" ; rdfs:subClassOf obo:HP_0003887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003889 oboInOwl:hasDbXref "UMLS:C4025527" ; oboInOwl:hasExactSynonym "Abnormality of the deltoid tuberosities" ; oboInOwl:id "HP:0003889" ; a owl:Class ; rdfs:label "Abnormal deltoid tuberosity morphology" ; rdfs:subClassOf obo:HP_0003926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002498 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003890 oboInOwl:hasDbXref "UMLS:C2674600" ; oboInOwl:id "HP:0003890" ; a owl:Class ; rdfs:label "Prominent deltoid tuberosities" ; rdfs:subClassOf obo:HP_0003889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002498 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003891 obo:IAO_0000115 "An anomaly of the humeral epiphysis." ; oboInOwl:hasDbXref "UMLS:C4021714" ; oboInOwl:hasExactSynonym "Abnormality of end part of the long bone of the upper arm", "Abnormality of the humeral epiphyses" ; oboInOwl:id "HP:0003891" ; a owl:Class ; rdfs:label "Abnormality of the humeral epiphysis" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0003839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003892 obo:IAO_0000115 "Lack of formation of bone in the epiphysis of the humerus." ; oboInOwl:hasDbXref "UMLS:C4021713" ; oboInOwl:hasExactSynonym "Absent maturation of end part of long bone in upper arm", "Absent ossification of the humeral epiphyses" ; oboInOwl:id "HP:0003892" ; a owl:Class ; rdfs:comment "Normally, the proximal humeral epiphysis can be visualized at about 40 weeks of gestation." ; rdfs:label "Absent humeral epiphyseal ossification" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0012791 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004382 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003893 obo:IAO_0000115 "Ossification of the humeral epiphysis at an earlier age than normal." ; oboInOwl:hasDbXref "UMLS:C4020836", "UMLS:C4025526" ; oboInOwl:hasExactSynonym "Accelerated maturation of end part of long bone in upper arm" ; oboInOwl:hasRelatedSynonym "Advanced maturation of the humeral epiphyses" ; oboInOwl:id "HP:0003893" ; a owl:Class ; rdfs:label "Advanced ossification of the humeral epiphysis" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0010656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004382 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003894 obo:IAO_0000115 "A delay in the process of formation and maturation of the humeral epiphysis." ; oboInOwl:hasDbXref "UMLS:C4021712", "UMLS:C4280543" ; oboInOwl:hasExactSynonym "Delayed maturation/delayed ossification of the humeral epiphyses" ; oboInOwl:hasRelatedSynonym "Delayed maturation of the end part of the long bone in upper arm" ; oboInOwl:id "HP:0003894" ; a owl:Class ; rdfs:label "Delayed humeral epiphyseal ossification" ; rdfs:subClassOf obo:HP_0003840, obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004382 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003895 oboInOwl:hasDbXref "UMLS:C4025525" ; oboInOwl:hasExactSynonym "Flattened end part of long bone in upper arm" ; oboInOwl:id "HP:0003895" ; a owl:Class ; rdfs:label "Flattened humeral epiphyses" ; rdfs:subClassOf obo:HP_0003071, obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003896 oboInOwl:hasDbXref "UMLS:C4025524" ; oboInOwl:hasExactSynonym "Irregular end part of long bone in upper arm" ; oboInOwl:id "HP:0003896" ; a owl:Class ; rdfs:label "Irregular humeral epiphyses" ; rdfs:subClassOf obo:HP_0003842, obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003897 oboInOwl:hasDbXref "UMLS:C4025523", "UMLS:C4280542" ; oboInOwl:hasRelatedSynonym "Irregular maturation of the end part of the long bone in upper arm" ; oboInOwl:id "HP:0003897" ; a owl:Class ; rdfs:label "Irregular ossification of the humeral epiphyses" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0010656, obo:HP_0012791 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004382 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003898 oboInOwl:hasDbXref "UMLS:C4025522" ; oboInOwl:hasExactSynonym "Large end part of long bone in upper arm" ; oboInOwl:id "HP:0003898" ; a owl:Class ; rdfs:label "Large humeral epiphyses" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003899 oboInOwl:hasDbXref "UMLS:C4025521" ; oboInOwl:hasExactSynonym "Round end part of long bone in upper arm" ; oboInOwl:id "HP:0003899" ; a owl:Class ; rdfs:label "Round humeral epiphyses" ; rdfs:subClassOf obo:HP_0003843, obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003900 oboInOwl:hasDbXref "UMLS:C4025520" ; oboInOwl:hasExactSynonym "Small end part of long bone in upper arm" ; oboInOwl:id "HP:0003900" ; a owl:Class ; rdfs:label "Small humeral epiphyses" ; rdfs:subClassOf obo:HP_0003844, obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003901 oboInOwl:hasDbXref "UMLS:C4025519" ; oboInOwl:id "HP:0003901" ; a owl:Class ; rdfs:label "Stippled calcification of the humeral epiphyses" ; rdfs:subClassOf obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0003902 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the humeral epiphysis." ; oboInOwl:hasDbXref "UMLS:C4021711" ; oboInOwl:hasExactSynonym "Stippled ossification of the humeral epiphyses" ; oboInOwl:id "HP:0003902" ; a owl:Class ; rdfs:label "Epiphyseal stippling of the humerus" ; rdfs:subClassOf obo:HP_0003897, obo:HP_0010655 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003903 obo:IAO_0000115 "Increased width of the humeral epiphysis." ; oboInOwl:hasDbXref "UMLS:C4021710" ; oboInOwl:hasExactSynonym "Wide end part of long bone in upper arm", "Wide humeral epiphyses" ; oboInOwl:id "HP:0003903" ; a owl:Class ; rdfs:label "Broad humeral epiphyses" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0003904 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004382 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003904 oboInOwl:hasDbXref "UMLS:C4021709" ; oboInOwl:hasExactSynonym "Broad epiphyses of the upper limbs", "Wide end part of upper limb bones" ; oboInOwl:id "HP:0003904" ; a owl:Class ; rdfs:label "Wide epiphyses of the upper limbs" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003905 oboInOwl:hasBroadSynonym "Abnormality of arm long bone growth plate" ; oboInOwl:hasDbXref "UMLS:C4025518", "UMLS:C4280541" ; oboInOwl:id "HP:0003905" ; a owl:Class ; rdfs:label "Abnormality of the humeral epiphyseal plate" ; rdfs:subClassOf obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002516 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003906 obo:IAO_0000115 "Increased width of the humeral epiphyseal growth plate." ; oboInOwl:hasBroadSynonym "Wide long bone of arm growth plate" ; oboInOwl:hasDbXref "UMLS:C4021708", "UMLS:C4280540" ; oboInOwl:hasExactSynonym "Wide humeral epiphyseal plate" ; oboInOwl:id "HP:0003906" ; a owl:Class ; rdfs:label "Broad humeral epiphyseal plate" ; rdfs:subClassOf obo:HP_0003846, obo:HP_0003905 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002516 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003907 oboInOwl:hasDbXref "UMLS:C4025517" ; oboInOwl:hasExactSynonym "Abnormality of the humeral metaphyses", "Abnormality of the wide portion of the long bone in upper arm" ; oboInOwl:id "HP:0003907" ; a owl:Class ; rdfs:label "Abnormal humeral metaphysis morphology" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0009809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003908 obo:IAO_0000115 "Fracture or fragmentation at the lateral portion of the metaphysis of a long bone. The radiographic appearance is that of a small corner of metaphysis separated from the metaphyseal edge by thin linear radiolucency. This feature can be observed in child abuse but fragmented appearance of the metaphysis or facture-like lesions can also be detected in the setting of certain skeletal dysplasias." ; oboInOwl:hasDbXref "UMLS:C4025516" ; oboInOwl:hasExactSynonym "Bucket handle fracture", "Metaphyseal corner fracture" ; oboInOwl:id "HP:0003908" ; a owl:Class ; rdfs:comment "A corner fracture is a subepiphyseal planer fracture through immature metaphyseal bone. The appearance of a corner, avulsion or bucket handle depends on the extent of bone failure and radiographic projection. Bone can fail in this pattern from both shearing and tensile stresses. The weakest area of bone for a given loading condition determines the injury threshold for that structure." ; rdfs:label "Corner fracture of metaphysis" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0003909 oboInOwl:hasDbXref "UMLS:C4025515" ; oboInOwl:id "HP:0003909" ; a owl:Class ; rdfs:label "Cortical subperiosteal resorption of humeral metaphyses" ; rdfs:subClassOf obo:HP_0003907 . obo:HP_0003910 oboInOwl:hasDbXref "UMLS:C4021707" ; oboInOwl:hasExactSynonym "Enlarged wide portion of long bone of upper arm", "Expanded humeral metaphyses" ; oboInOwl:id "HP:0003910" ; a owl:Class ; rdfs:label "Enlarged humeral metaphyses" ; rdfs:subClassOf obo:HP_0003051, obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001602 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003911 obo:IAO_0000115 "Flaring (increase of width with a splayed appearance) of the humeral metaphysis." ; oboInOwl:hasAlternativeId "HP:0003925" ; oboInOwl:hasDbXref "UMLS:C4020835", "UMLS:C4020912" ; oboInOwl:hasExactSynonym "Flared wide portion of long bone of upper arm", "Wide/broad humeral metaphysis" ; oboInOwl:hasRelatedSynonym "Flared humerus" ; oboInOwl:id "HP:0003911" ; a owl:Class ; rdfs:label "Flared humeral metaphysis" ; rdfs:subClassOf obo:HP_0003849, obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003912 oboInOwl:hasDbXref "UMLS:C4025514" ; oboInOwl:id "HP:0003912" ; a owl:Class ; rdfs:label "Frayed humeral metaphyses" ; rdfs:subClassOf obo:HP_0003907 . obo:HP_0003913 oboInOwl:hasDbXref "UMLS:C4021706" ; oboInOwl:hasExactSynonym "Irregular humeral metaphyses", "Irregular wide portion of long bone in upper arm" ; oboInOwl:id "HP:0003913" ; a owl:Class ; rdfs:label "Humeral metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003850, obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003914 oboInOwl:hasDbXref "UMLS:C4025513" ; oboInOwl:hasExactSynonym "Irregular bone maturation of the wide portion of the long bone in upper arm" ; oboInOwl:id "HP:0003914" ; a owl:Class ; rdfs:label "Irregular ossification of humeral metaphyses" ; rdfs:subClassOf obo:HP_0003907, obo:HP_0012791 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0013749 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003915 oboInOwl:hasDbXref "UMLS:C4025512" ; oboInOwl:id "HP:0003915" ; a owl:Class ; rdfs:label "Lytic defects of the humeral metaphysis" ; rdfs:subClassOf obo:HP_0003851, obo:HP_0003907 . obo:HP_0003916 oboInOwl:hasDbXref "UMLS:C4025511" ; oboInOwl:id "HP:0003916" ; a owl:Class ; rdfs:comment "Normal-density transverse bands of the humerus" ; rdfs:label "Normal-density transverse humeral bands" ; rdfs:subClassOf obo:HP_0003852, obo:HP_0003907 . obo:HP_0003917 oboInOwl:hasDbXref "UMLS:C4025510" ; oboInOwl:hasExactSynonym "Pointed wide portion of long bone of upper arm" ; oboInOwl:id "HP:0003917" ; a owl:Class ; rdfs:label "Pointed humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000944 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003918 oboInOwl:hasDbXref "UMLS:C4025509" ; oboInOwl:hasExactSynonym "Hardening of wide portion of long bone of upper arm", "Stiffening of wide portion of long bone of upper arm" ; oboInOwl:id "HP:0003918" ; a owl:Class ; rdfs:label "Sclerotic humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 . obo:HP_0003919 oboInOwl:hasDbXref "UMLS:C4025508" ; oboInOwl:id "HP:0003919" ; a owl:Class ; rdfs:label "Sclerotic humeral metaphysis with longitudinal striations" ; rdfs:subClassOf obo:HP_0003918 . obo:HP_0003920 oboInOwl:hasDbXref "UMLS:C4025507" ; oboInOwl:hasExactSynonym "Sloping metaphysis of long bone of upper arm" ; oboInOwl:id "HP:0003920" ; a owl:Class ; rdfs:label "Sloping humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001481 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003921 oboInOwl:hasDbXref "UMLS:C4025506" ; oboInOwl:hasExactSynonym "Laterally sloping metaphysis of long bone of upper arm" ; oboInOwl:id "HP:0003921" ; a owl:Class ; rdfs:label "Laterally sloping humeral metaphysis" ; rdfs:subClassOf obo:HP_0003920 . obo:HP_0003922 oboInOwl:hasDbXref "UMLS:C4025505" ; oboInOwl:hasExactSynonym "Spurred metaphysis of long bone of upper arm" ; oboInOwl:id "HP:0003922" ; a owl:Class ; rdfs:label "Spurred humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 . obo:HP_0003923 oboInOwl:hasDbXref "UMLS:C4025504" ; oboInOwl:hasExactSynonym "Square metaphysis of long bone of upper arm" ; oboInOwl:id "HP:0003923" ; a owl:Class ; rdfs:label "Square humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000413 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003924 oboInOwl:hasDbXref "UMLS:C4025503" ; oboInOwl:hasExactSynonym "Speckled calcification in metaphysis of long bone of upper arm" ; oboInOwl:id "HP:0003924" ; a owl:Class ; rdfs:label "Stippled calcification of humeral metaphysis" ; rdfs:subClassOf obo:HP_0003907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0003926 obo:IAO_0000115 "An anomaly of the humeral diaphysis." ; oboInOwl:hasDbXref "UMLS:C4025502" ; oboInOwl:hasExactSynonym "Abnormality of shaft of long bone in upper arm", "Abnormality of the humeral diaphysis" ; oboInOwl:id "HP:0003926" ; a owl:Class ; rdfs:label "Abnormal humeral diaphysis morphology" ; rdfs:subClassOf obo:HP_0009808, obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003927 obo:IAO_0000115 "An abnormal irregularity of the cortical surface of the diaphysis (shaft) of the humerus." ; oboInOwl:hasDbXref "UMLS:C4025501" ; oboInOwl:id "HP:0003927" ; a owl:Class ; rdfs:label "Cortical irregularity of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003858, obo:HP_0003867, obo:HP_0003926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005731 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003928 oboInOwl:hasDbXref "UMLS:C4025500" ; oboInOwl:id "HP:0003928" ; a owl:Class ; rdfs:label "Cortical thickening of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003859, obo:HP_0003926 . obo:HP_0003929 oboInOwl:hasDbXref "UMLS:C4025499" ; oboInOwl:id "HP:0003929" ; a owl:Class ; rdfs:label "Ground glass opacity of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003926 . obo:HP_0003930 oboInOwl:hasDbXref "UMLS:C4021705" ; oboInOwl:hasExactSynonym "Humeral diaphyseal lysis" ; oboInOwl:id "HP:0003930" ; a owl:Class ; rdfs:label "Lytic defects of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003926 . obo:HP_0003931 oboInOwl:hasDbXref "UMLS:C4025498" ; oboInOwl:id "HP:0003931" ; a owl:Class ; rdfs:label "Periosteal new bone of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003926, obo:HP_0030314 . obo:HP_0003932 oboInOwl:hasDbXref "UMLS:C4025497" ; oboInOwl:id "HP:0003932" ; a owl:Class ; rdfs:label "Sclerotic foci of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003926 . obo:HP_0003933 oboInOwl:hasDbXref "UMLS:C4025496" ; oboInOwl:hasExactSynonym "Increased bone density in shaft of long bone in upper arm" ; oboInOwl:id "HP:0003933" ; a owl:Class ; rdfs:label "Sclerosis of humeral diaphysis" ; rdfs:subClassOf obo:HP_0003860, obo:HP_0003926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0003934 oboInOwl:hasDbXref "UMLS:C4025495" ; oboInOwl:hasExactSynonym "Slender shaft of long bone in upper arm" ; oboInOwl:id "HP:0003934" ; a owl:Class ; rdfs:label "Slender humeral diaphysis" ; rdfs:subClassOf obo:HP_0003926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003935 obo:IAO_0000115 "Increased width of the humeral diaphysis." ; oboInOwl:hasDbXref "UMLS:C4021704" ; oboInOwl:hasExactSynonym "Broad humeral diaphysis", "Broad shaft of long bone in upper arm", "Wide shaft of long bone in upper arm" ; oboInOwl:id "HP:0003935" ; a owl:Class ; rdfs:label "Wide humeral diaphysis" ; rdfs:subClassOf obo:HP_0003861, obo:HP_0003926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003938 oboInOwl:hasDbXref "UMLS:C4025494" ; oboInOwl:hasExactSynonym "Bone fusion involving the elbow" ; oboInOwl:id "HP:0003938" ; a owl:Class ; rdfs:label "Synostosis involving the elbow" ; rdfs:subClassOf obo:HP_0009811, obo:HP_0100238 . obo:HP_0003939 obo:IAO_0000115 "An abnormal osseous union (fusion) between the ulna and the humerus." ; oboInOwl:hasDbXref "SNOMEDCT_US:205330003", "UMLS:C0431799" ; oboInOwl:hasExactSynonym "Humeral ulnar synostosis" ; oboInOwl:id "HP:0003939" ; a owl:Class ; rdfs:label "Humeroulnar synostosis" ; rdfs:subClassOf obo:HP_0003938, obo:HP_0100745 . obo:HP_0003940 oboInOwl:hasDbXref "SNOMEDCT_US:239866002", "UMLS:C0409954" ; oboInOwl:id "HP:0003940" ; a owl:Class ; rdfs:label "Osteoarthritis of the elbow" ; rdfs:subClassOf obo:HP_0002758, obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001461 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003941 oboInOwl:hasDbXref "UMLS:C4025493" ; oboInOwl:id "HP:0003941" ; a owl:Class ; rdfs:label "Stippled calcification of the elbow" ; rdfs:subClassOf obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001461 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0003942 oboInOwl:hasDbXref "UMLS:C4025492" ; oboInOwl:id "HP:0003942" ; a owl:Class ; rdfs:label "Synovial chondromatosis of the elbow" ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0003943 oboInOwl:hasDbXref "UMLS:C4025491" ; oboInOwl:hasExactSynonym "Abnormality of the joint spaces of the elbow" ; oboInOwl:id "HP:0003943" ; a owl:Class ; rdfs:label "Abnormality of the joint spaces of the elbow" ; rdfs:subClassOf obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004099 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003944 oboInOwl:hasDbXref "UMLS:C4025490" ; oboInOwl:hasExactSynonym "Narrow joint spaces of the elbow" ; oboInOwl:id "HP:0003944" ; a owl:Class ; rdfs:label "Narrow joint spaces of the elbow" ; rdfs:subClassOf obo:HP_0003943 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004099 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003945 oboInOwl:hasDbXref "UMLS:C4025489" ; oboInOwl:id "HP:0003945" ; a owl:Class ; rdfs:label "Irregular articular surfaces of the elbow joints" ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0003946 oboInOwl:hasDbXref "UMLS:C4025488" ; oboInOwl:hasExactSynonym "Abnormality of end part of the elbow bone" ; oboInOwl:id "HP:0003946" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the elbow" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003947 obo:IAO_0000115 "A delay in the process of formation and maturation of the epiphysis of one or more long bones that are part of the elbow." ; oboInOwl:hasDbXref "UMLS:C4025487" ; oboInOwl:hasExactSynonym "Delayed maturation of the end part of the elbow bone" ; oboInOwl:id "HP:0003947" ; a owl:Class ; rdfs:label "Delayed elbow epiphyseal ossification" ; rdfs:subClassOf obo:HP_0003840, obo:HP_0003946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003948 oboInOwl:hasDbXref "UMLS:C4025486" ; oboInOwl:hasExactSynonym "Irregular end part of the elbow bone" ; oboInOwl:id "HP:0003948" ; a owl:Class ; rdfs:label "Irregular epiphyses of the elbow" ; rdfs:subClassOf obo:HP_0003842, obo:HP_0003946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003949 oboInOwl:hasDbXref "UMLS:C4025485" ; oboInOwl:hasExactSynonym "Abnormal wide portion of elbow bone" ; oboInOwl:id "HP:0003949" ; a owl:Class ; rdfs:label "Abnormal elbow metaphysis morphology" ; rdfs:subClassOf obo:HP_0009809, obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009811 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003950 oboInOwl:hasDbXref "UMLS:C4025484" ; oboInOwl:hasExactSynonym "Flared wide portion of elbow bone" ; oboInOwl:id "HP:0003950" ; a owl:Class ; rdfs:label "Flared elbow metaphyses" ; rdfs:subClassOf obo:HP_0003849, obo:HP_0003949 . obo:HP_0003951 obo:IAO_0000115 "Irregularity of the normally smooth surface of the metaphysis at the distal end of the humerus (at the elbow)." ; oboInOwl:hasDbXref "UMLS:C4021703" ; oboInOwl:hasExactSynonym "Irregular metaphyses of elbow", "Irregular wide portion of elbow bone" ; oboInOwl:id "HP:0003951" ; a owl:Class ; rdfs:label "Distal humeral metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003913, obo:HP_0003949 . obo:HP_0003952 oboInOwl:hasDbXref "UMLS:C4021702" ; oboInOwl:hasExactSynonym "Vertical linear mixed lucent and sclerotic pattern of metaphyses" ; oboInOwl:id "HP:0003952" ; a owl:Class ; rdfs:label "Sclerotic foci of metaphyses of the elbow" ; rdfs:subClassOf obo:HP_0003854, obo:HP_0003949 . obo:HP_0003953 obo:IAO_0000115 "Absence of one or more forearm bones associated with congenital failure of development." ; oboInOwl:hasDbXref "UMLS:C4021701" ; oboInOwl:hasExactSynonym "Absent forearm bone", "Aplasia of the forearm bones" ; oboInOwl:id "HP:0003953" ; a owl:Class ; rdfs:label "Absent forearm bone" ; rdfs:subClassOf obo:HP_0006503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003954 oboInOwl:hasDbXref "UMLS:C4025483" ; oboInOwl:hasExactSynonym "Angulated forearm bones" ; oboInOwl:id "HP:0003954" ; a owl:Class ; rdfs:label "Angulated forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003955 obo:IAO_0000115 "A descriptive term for a forearm bone that appears to have an additional bone within it on radiography." ; oboInOwl:hasDbXref "UMLS:C4025482" ; oboInOwl:hasExactSynonym "Bone-in-a-bone appearance of forearm" ; oboInOwl:id "HP:0003955" ; a owl:Class ; rdfs:label "Bone-in-a-bone appearance of forearm" ; rdfs:subClassOf obo:HP_0002973 . obo:HP_0003956 obo:IAO_0000115 "A bending or abnormal curvature affecting either the radius, the ulna, or both." ; oboInOwl:hasDbXref "UMLS:C4025481" ; oboInOwl:hasExactSynonym "Bowed forearm bones" ; oboInOwl:id "HP:0003956" ; a owl:Class ; rdfs:label "Bowed forearm bones" ; rdfs:subClassOf obo:HP_0006488, obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003957 oboInOwl:hasDbXref "UMLS:C4021842" ; oboInOwl:id "HP:0003957" ; a owl:Class ; rdfs:label "Cortical thickening of the forearm bones" ; rdfs:subClassOf obo:HP_0040070, obo:HP_0040072 . obo:HP_0003958 oboInOwl:hasDbXref "UMLS:C4025480" ; oboInOwl:id "HP:0003958" ; a owl:Class ; rdfs:label "Cross-fusion of the forearm bones" ; rdfs:subClassOf obo:HP_0040072 . obo:HP_0003959 oboInOwl:hasDbXref "UMLS:C4025479" ; oboInOwl:hasExactSynonym "Deformed forearm bones" ; oboInOwl:id "HP:0003959" ; a owl:Class ; rdfs:label "Deformed forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003960 oboInOwl:hasDbXref "UMLS:C4025478" ; oboInOwl:id "HP:0003960" ; a owl:Class ; rdfs:label "Exostoses of the forearm bones" ; rdfs:subClassOf obo:HP_0040072, obo:HP_0100777 . obo:HP_0003961 obo:IAO_0000115 "Bone fracture in the radius, ulna, or wrist." ; oboInOwl:hasDbXref "UMLS:C4025477" ; oboInOwl:hasExactSynonym "Broken forearm", "Fracture of the forearm", "Fractured forearm bones" ; oboInOwl:id "HP:0003961" ; a owl:Class ; rdfs:label "Fractured forearm bones" ; rdfs:subClassOf obo:HP_0020110, obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003963 oboInOwl:hasDbXref "UMLS:C4025476" ; oboInOwl:id "HP:0003963" ; a owl:Class ; rdfs:label "Lytic defects of the forearm bones" ; rdfs:subClassOf obo:HP_0040072 . obo:HP_0003964 oboInOwl:hasDbXref "UMLS:C4025475" ; oboInOwl:id "HP:0003964" ; a owl:Class ; rdfs:label "Osteoporotic forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0003965 oboInOwl:hasDbXref "UMLS:C4025474" ; oboInOwl:id "HP:0003965" ; a owl:Class ; rdfs:label "Pseudarthrosis of the forearm bones" ; rdfs:subClassOf obo:HP_0040072 . obo:HP_0003966 oboInOwl:hasDbXref "UMLS:C4025473" ; oboInOwl:id "HP:0003966" ; a owl:Class ; rdfs:label "Sclerotic foci in forearm bones" ; rdfs:subClassOf obo:HP_0040072 . obo:HP_0003967 oboInOwl:hasDbXref "UMLS:C4025472" ; oboInOwl:hasExactSynonym "Increased bone density of forearm bones" ; oboInOwl:id "HP:0003967" ; a owl:Class ; rdfs:label "Sclerotic forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003466 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003969 oboInOwl:hasDbXref "UMLS:C4025471" ; oboInOwl:id "HP:0003969" ; a owl:Class ; rdfs:label "Slender forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003970 oboInOwl:hasDbXref "UMLS:C4025470" ; oboInOwl:id "HP:0003970" ; a owl:Class ; rdfs:label "Undermodelled forearm bones" ; rdfs:subClassOf obo:HP_0040072 . obo:HP_0003971 obo:IAO_0000115 "Abnormally wide bone of the skeleton of forearm." ; oboInOwl:hasDbXref "UMLS:C4021700" ; oboInOwl:hasExactSynonym "Broad forearm bones", "Wide forearm bones" ; oboInOwl:id "HP:0003971" ; a owl:Class ; rdfs:label "Broad forearm bones" ; rdfs:subClassOf obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003973 oboInOwl:hasDbXref "UMLS:C4021699" ; oboInOwl:hasExactSynonym "Broad radioulnar joints" ; oboInOwl:id "HP:0003973" ; a owl:Class ; rdfs:label "Wide radioulnar joints" ; rdfs:subClassOf obo:HP_0003037, obo:HP_0003059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001528 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003974 obo:IAO_0000115 "Missing radius bone associated with congenital failure of development." ; oboInOwl:hasAlternativeId "HP:0002819", "HP:0005012" ; oboInOwl:hasDbXref "UMLS:C1405984", "UMLS:C1838608", "UMLS:C1849314" ; oboInOwl:hasExactSynonym "Absent ossification/absence of radius", "Aplasia of the radius", "Missing outer large bone of forearm", "Radial aplasia", "absence of radius and ulna" ; oboInOwl:id "HP:0003974" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent radius" ; rdfs:subClassOf obo:HP_0003953, obo:HP_0006501, obo:HP_0009822 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003975 obo:IAO_0100001 "HP:0004000" ; oboInOwl:id "HP:0003975" ; a owl:Class ; rdfs:label "obsolete Chevron-shaped/cone-shaped radius" ; owl:deprecated true . obo:HP_0003976 oboInOwl:hasDbXref "UMLS:C4025468" ; oboInOwl:id "HP:0003976" ; a owl:Class ; rdfs:label "Constricted radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003977 oboInOwl:hasAlternativeId "HP:0005046" ; oboInOwl:hasDbXref "UMLS:C4025467" ; oboInOwl:id "HP:0003977" ; a owl:Class ; rdfs:label "Deformed radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003959 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003978 oboInOwl:hasDbXref "MSH:D011885", "SNOMEDCT_US:12676007", "UMLS:C0034628" ; oboInOwl:id "HP:0003978" ; a owl:Class ; rdfs:label "Fractured radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003084, obo:HP_0003961, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003979 oboInOwl:hasDbXref "UMLS:C4021841" ; oboInOwl:id "HP:0003979" ; a owl:Class ; rdfs:label "Lytic defects of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003963 . obo:HP_0003980 oboInOwl:hasDbXref "UMLS:C4025466" ; oboInOwl:id "HP:0003980" ; a owl:Class ; rdfs:label "Pseudarthrosis of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003965 . obo:HP_0003981 obo:IAO_0000115 "Increased width of the radius." ; oboInOwl:hasDbXref "UMLS:C4021698" ; oboInOwl:hasExactSynonym "Wide radius" ; oboInOwl:id "HP:0003981" ; a owl:Class ; rdfs:label "Broad radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003971, obo:HP_0005622 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003982 obo:IAO_0000115 "Missing ulna bone associated with congenital failure of development." ; oboInOwl:hasDbXref "UMLS:C2678397" ; oboInOwl:hasExactSynonym "Absent ossification/absent ulna", "Absent ulna" ; oboInOwl:hasRelatedSynonym "Absent ulnae" ; oboInOwl:id "HP:0003982" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplasia of the ulna" ; rdfs:subClassOf obo:HP_0003953, obo:HP_0006495, obo:HP_0009822 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003984 oboInOwl:hasDbXref "UMLS:C4025465" ; oboInOwl:id "HP:0003984" ; a owl:Class ; rdfs:label "Posteriorly dislocated ulna" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001922 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003985 oboInOwl:hasDbXref "UMLS:C4025464" ; oboInOwl:id "HP:0003985" ; a owl:Class ; rdfs:label "Exostoses of the ulna" ; rdfs:subClassOf obo:HP_0003960, obo:HP_0040071 . obo:HP_0003986 oboInOwl:hasDbXref "UMLS:C4025463" ; oboInOwl:id "HP:0003986" ; a owl:Class ; rdfs:label "Exostoses of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003960 . obo:HP_0003987 oboInOwl:hasDbXref "MSH:D014458", "SNOMEDCT_US:54556006", "UMLS:C0041601" ; oboInOwl:id "HP:0003987" ; a owl:Class ; rdfs:label "Fractured ulna" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0003961, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003988 obo:IAO_0000115 "Increased length of the ulna." ; oboInOwl:hasAlternativeId "HP:0006435" ; oboInOwl:hasDbXref "UMLS:C1848108" ; oboInOwl:hasExactSynonym "Disproportionately long ulnae" ; oboInOwl:id "HP:0003988" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long ulna" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003989 oboInOwl:hasDbXref "UMLS:C4025462" ; oboInOwl:id "HP:0003989" ; a owl:Class ; rdfs:label "Notched ulna" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001495 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003990 oboInOwl:hasDbXref "UMLS:C4025461" ; oboInOwl:id "HP:0003990" ; a owl:Class ; rdfs:label "Pointed ulna" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000944 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003991 obo:IAO_0000115 "Osteosclerosis (increased density related to increased bone mass) of the ulna." ; oboInOwl:hasDbXref "UMLS:C4021697" ; oboInOwl:hasExactSynonym "Sclerotic ulna" ; oboInOwl:id "HP:0003991" ; a owl:Class ; rdfs:label "Osteosclerosis of the ulna" ; rdfs:subClassOf obo:HP_0003967, obo:HP_0006392, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003992 obo:IAO_0000115 "Reduction in diameter of the ulna." ; oboInOwl:hasDbXref "UMLS:C1968814" ; oboInOwl:id "HP:0003992" ; a owl:Class ; rdfs:label "Slender ulna" ; rdfs:subClassOf obo:HP_0003100, obo:HP_0003969, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003993 obo:IAO_0000115 "Increased width of the ulna." ; oboInOwl:hasAlternativeId "HP:0200081" ; oboInOwl:hasDbXref "UMLS:C4020692", "UMLS:C4025460" ; oboInOwl:hasRelatedSynonym "Wide ulna" ; oboInOwl:id "HP:0003993" ; a owl:Class ; rdfs:label "Broad ulna" ; rdfs:subClassOf obo:HP_0003971, obo:HP_0005622, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003994 obo:IAO_0000115 "An injury of the wrist with displacement of any of the eight carpal bones." ; oboInOwl:hasAlternativeId "HP:0004992" ; oboInOwl:hasDbXref "MEDDRA:10013184", "SNOMEDCT_US:125618007", "UMLS:C0159941" ; oboInOwl:hasExactSynonym "Dislocated wrist", "Dislocations of the wrists" ; oboInOwl:id "HP:0003994" ; a owl:Class ; rdfs:label "Dislocated wrist" ; rdfs:subClassOf obo:HP_0003019, obo:HP_0030310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003995 oboInOwl:hasDbXref "UMLS:C4021696" ; oboInOwl:hasExactSynonym "Deformity of radial heads" ; oboInOwl:id "HP:0003995" ; a owl:Class ; rdfs:label "Abnormality of the radial head" ; rdfs:subClassOf obo:HP_0002818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003996 oboInOwl:hasDbXref "UMLS:C4025459" ; oboInOwl:id "HP:0003996" ; a owl:Class ; rdfs:label "Flattened radial head" ; rdfs:subClassOf obo:HP_0003995 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003997 oboInOwl:hasDbXref "UMLS:C4021695" ; oboInOwl:hasExactSynonym "Small radial head" ; oboInOwl:id "HP:0003997" ; a owl:Class ; rdfs:label "Hypoplastic radial head" ; rdfs:subClassOf obo:HP_0003995 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003998 oboInOwl:hasDbXref "UMLS:C4025458" ; oboInOwl:id "HP:0003998" ; a owl:Class ; rdfs:label "Constricted radial neck" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0003999 oboInOwl:hasAlternativeId "HP:0004011" ; oboInOwl:hasDbXref "UMLS:C4021694" ; oboInOwl:hasExactSynonym "Abnormality of radial epiphyseal plates" ; oboInOwl:id "HP:0003999" ; a owl:Class ; rdfs:label "Abnormality of radial epiphyses" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004000 obo:IAO_0000115 "The distal epiphysis (rounded portion of bone at the far end of the radius distal to the growth plate) has an abnormal cone-shaped appearance." ; oboInOwl:hasAlternativeId "HP:0003975" ; oboInOwl:hasDbXref "UMLS:C4025457" ; oboInOwl:hasExactSynonym "Chevron-shaped distal radial epiphysis" ; oboInOwl:id "HP:0004000" ; a owl:Class ; rdfs:comment "The phrase chevron-shaped (having the shape of a V or an inverted V) is synonymous." ; rdfs:label "Cone-shaped distal radial epiphysis" ; rdfs:subClassOf obo:HP_0003999, obo:HP_0010579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004001 oboInOwl:hasDbXref "UMLS:C4025456" ; oboInOwl:id "HP:0004001" ; a owl:Class ; rdfs:label "Medially deficient radial epiphyses" ; rdfs:subClassOf obo:HP_0003999 . obo:HP_0004002 oboInOwl:hasDbXref "UMLS:C4025455" ; oboInOwl:id "HP:0004002" ; a owl:Class ; rdfs:label "Flattened radial epiphyses" ; rdfs:subClassOf obo:HP_0003071, obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004003 oboInOwl:hasDbXref "UMLS:C4025454" ; oboInOwl:id "HP:0004003" ; a owl:Class ; rdfs:label "Medially flattened radial epiphyses" ; rdfs:subClassOf obo:HP_0004002 . obo:HP_0004004 oboInOwl:hasDbXref "UMLS:C4025453" ; oboInOwl:id "HP:0004004" ; a owl:Class ; rdfs:label "Irregular radial epiphyses" ; rdfs:subClassOf obo:HP_0003999, obo:HP_0010582 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004005 oboInOwl:hasDbXref "UMLS:C4025452" ; oboInOwl:id "HP:0004005" ; a owl:Class ; rdfs:label "Large radial epiphyses" ; rdfs:subClassOf obo:HP_0003999, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004006 oboInOwl:hasDbXref "UMLS:C4025451" ; oboInOwl:id "HP:0004006" ; a owl:Class ; rdfs:label "Round radial epiphyses" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004007 oboInOwl:hasDbXref "UMLS:C4025450" ; oboInOwl:id "HP:0004007" ; a owl:Class ; rdfs:label "Sclerotic radial epiphyses" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004008 oboInOwl:hasDbXref "UMLS:C4025449" ; oboInOwl:id "HP:0004008" ; a owl:Class ; rdfs:label "Sloping radial epiphyses" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002143 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004009 oboInOwl:hasDbXref "UMLS:C4025448" ; oboInOwl:id "HP:0004009" ; a owl:Class ; rdfs:label "Medially sloping radial epiphyses" ; rdfs:subClassOf obo:HP_0004008 . obo:HP_0004010 oboInOwl:hasDbXref "UMLS:C4025447" ; oboInOwl:id "HP:0004010" ; a owl:Class ; rdfs:label "Small radial epiphyses" ; rdfs:subClassOf obo:HP_0003999, obo:HP_0010585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004012 obo:IAO_0000115 "A premature fusion of the epiphyseal plates of the radius. Epiphyseal plates are located at the distal and proximal ends of the long bones, in this case of the radius and premature fusion will have an effect on the growh of the radial bone, inhibiting or at least disturbing the normal growth and development of the bone." ; oboInOwl:hasDbXref "UMLS:C4025446" ; oboInOwl:id "HP:0004012" ; a owl:Class ; rdfs:comment "The epiphyseal plate (or epiphysial plate, physis, or growth plate) is a hyaline cartilage plate in the metaphysis at each end of a long bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line. The growth plate has a very specific morphology in having a zonal arrangement. The growth plate includes a relatively inactive reserve zone at the epiphyseal end, moving distally into a proliferative and then hyper trophic zone and ending with a band of ossifying cartilage (the metaphysis)." ; rdfs:label "Premature fusion of the radial epiphyseal plates" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0016425 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004013 oboInOwl:hasDbXref "UMLS:C4025445" ; oboInOwl:id "HP:0004013" ; a owl:Class ; rdfs:label "Medially fused radial epiphyseal plates" ; rdfs:subClassOf obo:HP_0004012 . obo:HP_0004014 obo:IAO_0000115 "Abnormal increase in width of the epiphyseal growth plate of the radius." ; oboInOwl:hasDbXref "UMLS:C4021693" ; oboInOwl:hasExactSynonym "Wide radial epiphyseal plates" ; oboInOwl:id "HP:0004014" ; a owl:Class ; rdfs:label "Broad radial epiphyseal plate" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016425 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004015 oboInOwl:hasDbXref "UMLS:C4025444" ; oboInOwl:hasExactSynonym "Abnormality of radial metaphyses" ; oboInOwl:id "HP:0004015" ; a owl:Class ; rdfs:label "Abnormal radial metaphysis morphology" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0009809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004016 oboInOwl:hasDbXref "UMLS:C4025443" ; oboInOwl:id "HP:0004016" ; a owl:Class ; rdfs:label "Cupped radial metaphyses" ; rdfs:subClassOf obo:HP_0003848, obo:HP_0004015 . obo:HP_0004017 oboInOwl:hasDbXref "UMLS:C4025442" ; oboInOwl:id "HP:0004017" ; a owl:Class ; rdfs:label "Exostoses of the radial metaphysis" ; rdfs:subClassOf obo:HP_0003986, obo:HP_0004015 . obo:HP_0004018 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of the radius." ; oboInOwl:hasDbXref "UMLS:C4025441" ; oboInOwl:hasRelatedSynonym "Broadening of the distal radius" ; oboInOwl:id "HP:0004018" ; a owl:Class ; rdfs:label "Flared radial metaphysis" ; rdfs:subClassOf obo:HP_0003849, obo:HP_0004015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004019 obo:IAO_0000115 "Irregularity of the normally smooth surface of the metaphysis of the radius." ; oboInOwl:hasDbXref "UMLS:C4021692" ; oboInOwl:hasExactSynonym "Irregular radial metaphysis" ; oboInOwl:id "HP:0004019" ; a owl:Class ; rdfs:label "Radial metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003850, obo:HP_0004015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004020 oboInOwl:hasDbXref "UMLS:C4025440" ; oboInOwl:id "HP:0004020" ; a owl:Class ; rdfs:label "Irregular ossification of the radial metaphysis" ; rdfs:subClassOf obo:HP_0003336, obo:HP_0004015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0013751 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004021 oboInOwl:hasDbXref "UMLS:C4025439" ; oboInOwl:id "HP:0004021" ; a owl:Class ; rdfs:label "Lytic defects of radial metaphysis" ; rdfs:subClassOf obo:HP_0003851, obo:HP_0004015 . obo:HP_0004022 oboInOwl:hasDbXref "UMLS:C4025438" ; oboInOwl:id "HP:0004022" ; a owl:Class ; rdfs:label "Sclerotic radial metaphysis with longitudinal striations" ; rdfs:subClassOf obo:HP_0003854, obo:HP_0004015 . obo:HP_0004023 oboInOwl:hasDbXref "UMLS:C4025437" ; oboInOwl:id "HP:0004023" ; a owl:Class ; rdfs:label "Sloping radial metaphysis" ; rdfs:subClassOf obo:HP_0004015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001481 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004024 oboInOwl:hasDbXref "UMLS:C4025436" ; oboInOwl:id "HP:0004024" ; a owl:Class ; rdfs:label "Medially sloping radial metaphysis" ; rdfs:subClassOf obo:HP_0004023 . obo:HP_0004025 oboInOwl:hasDbXref "UMLS:C4025435" ; oboInOwl:id "HP:0004025" ; a owl:Class ; rdfs:label "Spurred radial metaphysis" ; rdfs:subClassOf obo:HP_0004015 . obo:HP_0004026 obo:IAO_0000115 "Increase in width (breadth) of the radial metaphysis." ; oboInOwl:hasDbXref "UMLS:C4021691" ; oboInOwl:hasExactSynonym "Wide radial metaphysis" ; oboInOwl:id "HP:0004026" ; a owl:Class ; rdfs:label "Broad radial metaphysis" ; rdfs:subClassOf obo:HP_0003856, obo:HP_0003981, obo:HP_0004015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004027 obo:IAO_0000115 "An anomaly of the radial diaphysis." ; oboInOwl:hasDbXref "UMLS:C4025434" ; oboInOwl:id "HP:0004027" ; a owl:Class ; rdfs:label "Abnormality of radial diaphysis" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0009808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004028 oboInOwl:hasDbXref "UMLS:C4025433" ; oboInOwl:id "HP:0004028" ; a owl:Class ; rdfs:label "Spurs of radial diaphysis" ; rdfs:subClassOf obo:HP_0004027 . obo:HP_0004029 oboInOwl:hasDbXref "UMLS:C4025432" ; oboInOwl:id "HP:0004029" ; a owl:Class ; rdfs:label "Lytic defects of radial diaphysis" ; rdfs:subClassOf obo:HP_0004027 . obo:HP_0004030 oboInOwl:hasDbXref "UMLS:C4025431" ; oboInOwl:id "HP:0004030" ; a owl:Class ; rdfs:label "Patchy sclerosis of radial diaphysis" ; rdfs:subClassOf obo:HP_0004027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001028 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004031 obo:IAO_0000115 "Increase in width of the diaphysis of radius." ; oboInOwl:hasDbXref "UMLS:C4021690" ; oboInOwl:hasExactSynonym "Wide radial diaphysis" ; oboInOwl:id "HP:0004031" ; a owl:Class ; rdfs:comment "Increased diameter of the shaft (diaphysis) of the radius." ; rdfs:label "Broad radial diaphysis" ; rdfs:subClassOf obo:HP_0004027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004032 obo:IAO_0000115 "Any structural abnormality of the olecranon, a bony eminence of the proximal ulna." ; oboInOwl:hasDbXref "UMLS:C4025430" ; oboInOwl:hasExactSynonym "Abnormality of the olecranon" ; oboInOwl:id "HP:0004032" ; a owl:Class ; rdfs:label "Abnormal olecranon morphology" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006810 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004033 oboInOwl:hasDbXref "UMLS:C4025429" ; oboInOwl:id "HP:0004033" ; a owl:Class ; rdfs:label "Curved olecranon" ; rdfs:subClassOf obo:HP_0004032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006810 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004034 oboInOwl:hasDbXref "UMLS:C4025428" ; oboInOwl:id "HP:0004034" ; a owl:Class ; rdfs:label "Irregular olecranon" ; rdfs:subClassOf obo:HP_0004032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006810 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004035 oboInOwl:hasDbXref "UMLS:C4025427" ; oboInOwl:hasExactSynonym "Abnormality of the styloid process of ulna" ; oboInOwl:id "HP:0004035" ; a owl:Class ; rdfs:label "Abnormal ulnar styloid process morphology" ; rdfs:subClassOf obo:HP_0004037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011575 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004036 oboInOwl:hasDbXref "UMLS:C4025426" ; oboInOwl:id "HP:0004036" ; a owl:Class ; rdfs:label "Long styloid process of ulna" ; rdfs:subClassOf obo:HP_0004035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011575 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004037 oboInOwl:hasDbXref "UMLS:C4021689" ; oboInOwl:hasExactSynonym "Abnormality of the epiphyseal plate of the ulna", "Abnormality of the ulnar epiphyses" ; oboInOwl:id "HP:0004037" ; a owl:Class ; rdfs:label "Abnormal ulnar epiphysis morphology" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004038 oboInOwl:id "HP:0004038" ; a owl:Class ; rdfs:comment "obsoleted on July 11, 2019." ; rdfs:label "obsolete Bony spicule of ulnar epiphyseal plate" ; owl:deprecated true . obo:HP_0004039 obo:IAO_0000115 "Any structural abnormality of the portion of the ulna between the epiphysis and the diaphysis." ; oboInOwl:hasDbXref "UMLS:C4025424" ; oboInOwl:hasExactSynonym "Abnormality of ulnar metaphysis" ; oboInOwl:id "HP:0004039" ; a owl:Class ; rdfs:label "Abnormal ulnar metaphysis morphology" ; rdfs:subClassOf obo:HP_0009809, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013748 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004040 oboInOwl:hasDbXref "UMLS:C4025423" ; oboInOwl:id "HP:0004040" ; a owl:Class ; rdfs:label "Corner fragments of ulnar metaphysis" ; rdfs:subClassOf obo:HP_0004039 . obo:HP_0004041 oboInOwl:hasDbXref "UMLS:C4025422" ; oboInOwl:id "HP:0004041" ; a owl:Class ; rdfs:label "Cupped ulnar metaphysis" ; rdfs:subClassOf obo:HP_0004039 . obo:HP_0004042 obo:IAO_0000115 "Irregularity of the normally smooth surface of the metaphysis of the ulna." ; oboInOwl:hasDbXref "UMLS:C4021688" ; oboInOwl:hasExactSynonym "Irregular ulnar metaphysis" ; oboInOwl:id "HP:0004042" ; a owl:Class ; rdfs:label "Ulnar metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003850, obo:HP_0004039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013748 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004043 oboInOwl:hasDbXref "UMLS:C4025421" ; oboInOwl:id "HP:0004043" ; a owl:Class ; rdfs:label "Lytic defects of ulnar metaphysis" ; rdfs:subClassOf obo:HP_0004039, obo:HP_0045039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0013748 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004044 oboInOwl:hasDbXref "UMLS:C4025420" ; oboInOwl:id "HP:0004044" ; a owl:Class ; rdfs:label "Pointed ulnar metaphysis" ; rdfs:subClassOf obo:HP_0004039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000944 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013748 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004045 obo:IAO_0000115 "A sloped configuration of the metaphysis (shaft) of the ulna." ; oboInOwl:hasDbXref "UMLS:C4025419" ; oboInOwl:id "HP:0004045" ; a owl:Class ; rdfs:label "Sloping ulnar metaphysis" ; rdfs:subClassOf obo:HP_0004039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001481 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013748 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004046 oboInOwl:hasDbXref "UMLS:C4025418" ; oboInOwl:id "HP:0004046" ; a owl:Class ; rdfs:label "Spurred ulnar metaphysis" ; rdfs:subClassOf obo:HP_0003855, obo:HP_0004039 . obo:HP_0004047 obo:IAO_0000115 "Increase in width (breadth) of the ulnar metaphysis." ; oboInOwl:hasDbXref "UMLS:C4021687" ; oboInOwl:hasExactSynonym "Broad ulnar metaphysis" ; oboInOwl:id "HP:0004047" ; a owl:Class ; rdfs:label "Wide ulnar metaphysis" ; rdfs:subClassOf obo:HP_0003856, obo:HP_0004039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013748 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004048 oboInOwl:hasDbXref "UMLS:C4025417" ; oboInOwl:id "HP:0004048" ; a owl:Class ; rdfs:label "Narrow joint spaces of wrist" ; rdfs:subClassOf obo:HP_0003019 . obo:HP_0004049 oboInOwl:hasDbXref "UMLS:C4025416" ; oboInOwl:id "HP:0004049" ; a owl:Class ; rdfs:label "Decreased carpal angles of wrist" ; rdfs:subClassOf obo:HP_0003019 . obo:HP_0004050 obo:IAO_0000115 "The total absence of the hand, with no bony elements distal to the radius or ulna." ; oboInOwl:hasDbXref "SNOMEDCT_US:371199008", "UMLS:C0265594" ; oboInOwl:hasExactSynonym "Absent hand", "Acheiria" ; oboInOwl:id "HP:0004050" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent hand" ; rdfs:subClassOf obo:HP_0005927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004051 obo:IAO_0000115 "Ossification of hand bones at an earlier age than normal." ; oboInOwl:hasDbXref "UMLS:C4020834" ; oboInOwl:hasRelatedSynonym "Accelerated maturation of hand bones", "Advanced maturation of the hand bones" ; oboInOwl:id "HP:0004051" ; a owl:Class ; rdfs:label "Advanced ossification of the hand bones" ; rdfs:subClassOf obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004052 obo:IAO_0000115 "Ossification of hand bones is less advanced than would be expected according to age-adjusted norms." ; oboInOwl:hasDbXref "UMLS:C4020833", "UMLS:C4021686" ; oboInOwl:hasExactSynonym "Delay maturation/delayed ossification of the hand" ; oboInOwl:hasRelatedSynonym "Delayed maturation of the hand bones" ; oboInOwl:id "HP:0004052" ; a owl:Class ; rdfs:label "Delayed ossification of the hand bones" ; rdfs:subClassOf obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004053 obo:IAO_0000115 "Pattern of hand-wrist development does not fit the normal sequence of ossification of the individual bones of the hand." ; oboInOwl:hasAlternativeId "HP:0006204" ; oboInOwl:hasDbXref "UMLS:C4021685" ; oboInOwl:hasExactSynonym "Disharmonic maturation of the hand bones", "Dysharmonic ossification of the hand bones" ; oboInOwl:id "HP:0004053" ; a owl:Class ; rdfs:label "Dysharmonic maturation of the hand bones" ; rdfs:subClassOf obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000692 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004054 obo:IAO_0000115 "Osteosclerosis affecting one or more bones of the hand." ; oboInOwl:hasAlternativeId "HP:0004055" ; oboInOwl:hasDbXref "UMLS:C4021684" ; oboInOwl:hasExactSynonym "Generalised sclerosis of hand bones", "Generalized sclerosis of hand bones", "Hand bone sclerosis", "Increased bone density in hand bone", "Increased bone density in hand bones" ; oboInOwl:id "HP:0004054" ; a owl:Class ; rdfs:label "Sclerosis of hand bone" ; rdfs:subClassOf obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004057 obo:IAO_0000115 "Fusion of the hands and feet by a thin membrane of skin (scarring) seen in forms of dystrophic epidermolysis bullosa and leading to a \"mitten\" hand deformity." ; oboInOwl:hasDbXref "UMLS:C1969236" ; oboInOwl:hasExactSynonym "Pseudosyndactyly" ; oboInOwl:id "HP:0004057" ; a owl:Class ; rdfs:comment "Mitten deformity is also referred to as pseudosyndactyly, which should not be confused with true syndactyly (actual and complete fusion of fingers). Antenatally, pseudosyndactyly can be misinterpreted as syndactyly." ; rdfs:label "Mitten deformity" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0004058 oboInOwl:hasDbXref "UMLS:C4025415" ; oboInOwl:id "HP:0004058" ; a owl:Class ; rdfs:label "Hand monodactyly" ; rdfs:subClassOf obo:HP_0001180 . obo:HP_0004059 obo:IAO_0000115 "Wrist is bent inward toward the thumb because of a congenital defect associated with shortening or absence of the radius." ; oboInOwl:hasDbXref "UMLS:C4025414" ; oboInOwl:id "HP:0004059" ; a owl:Class ; rdfs:label "Radial club hand" ; rdfs:subClassOf obo:HP_0006433, obo:HP_0009486 . obo:HP_0004060 obo:IAO_0000115 "A hand in which the fingers are of nearly equal length and deflected at the first interphalangeal joint, so as to give a forklike shape consisting of separation of the first and second as well as the third and fourth digits." ; oboInOwl:hasDbXref "SNOMEDCT_US:249755001", "UMLS:C0426874" ; oboInOwl:hasExactSynonym "trident abnormality", "trident deformity" ; oboInOwl:id "HP:0004060" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This abnormality is often seen in patients with achondroplasia." ; rdfs:label "Trident hand" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0004066 oboInOwl:consider "HP:0009602" ; oboInOwl:id "HP:0004066" ; a owl:Class ; rdfs:label "obsolete Laterally deviated thumb phalanges" ; owl:deprecated true . obo:HP_0004083 oboInOwl:consider "HP:0005895" ; oboInOwl:id "HP:0004083" ; a owl:Class ; rdfs:label "obsolete Laterally deviated terminal thumb phalanx" ; owl:deprecated true . obo:HP_0004090 oboInOwl:consider "HP:0009662" ; oboInOwl:id "HP:0004090" ; a owl:Class ; rdfs:label "obsolete Advanced maturation/advanced ossification of terminal thumb phalanx epiphysis" ; owl:deprecated true . obo:HP_0004095 oboInOwl:hasDbXref "UMLS:C4025413" ; oboInOwl:hasExactSynonym "Curved fingers" ; oboInOwl:id "HP:0004095" ; a owl:Class ; rdfs:label "Curved fingers" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004097 obo:IAO_0000115 "Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges." ; oboInOwl:hasAlternativeId "HP:0006229" ; oboInOwl:hasDbXref "SNOMEDCT_US:203556007", "SNOMEDCT_US:26517000", "UMLS:C0410740" ; oboInOwl:hasExactSynonym "Atypical position of finger", "Deviated fingers", "Finger pointing in a different direction than usual" ; oboInOwl:id "HP:0004097" ; a owl:Class ; rdfs:label "Deviation of finger" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0009484 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004099 obo:IAO_0000115 "Significant increase in the length and girth of most or all of a digit compared to its contralateral digit (if unaffected) or compared to what would be expected for age/body build. The increased girth is accompanied by an increase in the dorso-ventral dimension AND the lateral dimension of the digit." ; oboInOwl:hasDbXref "MEDDRA:10025386", "MSH:C562546", "SNOMEDCT_US:48449000", "UMLS:C0265552" ; oboInOwl:hasExactSynonym "Finger overgrowth", "Megalodactyly" ; oboInOwl:id "HP:0004099" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "There are no recognized standards for the girth of digits and this finding can vary substantially in the population. This assessment relies on the judgment of the examiner to recognize when the difference between the expected and the observed is significant. The affected digits should be specified. The definition does not mandate the component of the increased size (bone, connective tissue, etc.), but should exclude edema. The requirement that the girth is most, or all, of the digit is intended to distinguish this from broad fingertips. This should be distinguished from Broad fingers or Broad fingertips as the girth is circumferential in macrodactyly, which is not the case for broad fingers or broad fingertips, which are increased only (or predominantly) in their lateral (A/P) width." ; rdfs:label "Macrodactyly" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004100 obo:IAO_0000115 "An anomaly of the second finger, also known as the index finger." ; oboInOwl:hasDbXref "UMLS:C4021683" ; oboInOwl:hasExactSynonym "Abnormality of index finger", "Abnormality of the 2nd finger" ; oboInOwl:id "HP:0004100" ; a owl:Class ; rdfs:label "Abnormal 2nd finger morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004110 oboInOwl:consider "HP:0009542" ; oboInOwl:id "HP:0004110" ; a owl:Class ; rdfs:label "obsolete Radially deviated index finger phalanges" ; owl:deprecated true . obo:HP_0004112 obo:IAO_0000115 "An abnormal groove on the midline of the nose that may extend to the nasal tip." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T04:59:08Z" ; oboInOwl:hasDbXref "UMLS:C4025412" ; oboInOwl:hasExactSynonym "Central nasal groove", "Midline nasal groove" ; oboInOwl:id "HP:0004112" ; a owl:Class ; rdfs:label "Midline nasal groove" ; rdfs:subClassOf obo:HP_0004122 . obo:HP_0004121 oboInOwl:consider "HP:0009544" ; oboInOwl:id "HP:0004121" ; a owl:Class ; rdfs:label "obsolete Radially displaced proximal index finger phalanx" ; owl:deprecated true . obo:HP_0004122 obo:IAO_0000115 "This term groups together three conditions that presumably represent different degrees of severity of a midline defect of the nose or nasal tip." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T04:59:54Z" ; oboInOwl:hasAlternativeId "HP:0003190" ; oboInOwl:hasDbXref "UMLS:C4025411", "UMLS:C4280539" ; oboInOwl:hasExactSynonym "Central defect of nose", "Central nasal defect", "Midline defect of the nose", "Midline nasal defect" ; oboInOwl:hasRelatedSynonym "Central cleft of nose", "Midline cleft of nose" ; oboInOwl:id "HP:0004122" ; a owl:Class ; rdfs:label "Midline defect of the nose" ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0004132 obo:IAO_0000115 "An abnormal indentation of the skin in the region of the nasal tip." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T05:05:55Z" ; oboInOwl:hasDbXref "UMLS:C1863349" ; oboInOwl:hasExactSynonym "Dimple on nasal tip", "Dimpled tip of nose" ; oboInOwl:id "HP:0004132" ; a owl:Class ; rdfs:label "Dimple on nasal tip" ; rdfs:subClassOf obo:HP_0000436 . obo:HP_0004138 oboInOwl:consider "HP:0009541" ; oboInOwl:id "HP:0004138" ; a owl:Class ; rdfs:label "obsolete Metaphyseal abnormality of middle phalanx of the 2nd finger" ; owl:deprecated true . obo:HP_0004139 oboInOwl:consider "HP:0009569" ; oboInOwl:id "HP:0004139" ; a owl:Class ; rdfs:label "obsolete Flared metaphysis of middle phalanx of index finger" ; owl:deprecated true . obo:HP_0004143 oboInOwl:consider "HP:0009542" ; oboInOwl:id "HP:0004143" ; a owl:Class ; rdfs:label "obsolete Radially deviated terminal index finger phalanx" ; owl:deprecated true . obo:HP_0004144 obo:IAO_0100001 "HP:0009948" ; oboInOwl:id "HP:0004144" ; a owl:Class ; rdfs:label "obsolete Duplication of terminal index finger phalanx" ; owl:deprecated true . obo:HP_0004150 obo:IAO_0000115 "An anomaly of the third finger." ; oboInOwl:hasDbXref "UMLS:C4021682" ; oboInOwl:hasExactSynonym "Abnormality of the 3rd finger", "Abnormality of the middle finger" ; oboInOwl:id "HP:0004150" ; a owl:Class ; rdfs:label "Abnormal 3rd finger morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004153 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004153" ; a owl:Class ; rdfs:label "obsolete Overgrowth of middle finger" ; owl:deprecated true . obo:HP_0004157 obo:IAO_0100001 "HP:0009963" ; oboInOwl:id "HP:0004157" ; a owl:Class ; rdfs:label "obsolete Accessory middle-finger phalanges" ; owl:deprecated true . obo:HP_0004161 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004161" ; a owl:Class ; rdfs:label "obsolete Periosteal new bone of middle finger phalanges" ; owl:deprecated true . obo:HP_0004162 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004162" ; a owl:Class ; rdfs:label "obsolete Radially pointed middle finger phalanges" ; owl:deprecated true . obo:HP_0004168 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004168" ; a owl:Class ; rdfs:label "obsolete Radially pointed proximal middle-finger phalanx" ; owl:deprecated true . obo:HP_0004172 oboInOwl:hasDbXref "UMLS:C4025410" ; oboInOwl:hasExactSynonym "Abnormal middle finger bone of the middle finger" ; oboInOwl:id "HP:0004172" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004174 obo:IAO_0100001 "HP:0009963" ; oboInOwl:id "HP:0004174" ; a owl:Class ; rdfs:label "obsolete Accessory middle phalanx of middle finger" ; owl:deprecated true . obo:HP_0004175 oboInOwl:consider "HP:0004172" ; oboInOwl:id "HP:0004175" ; a owl:Class ; rdfs:label "obsolete Periosteal new bone of middle phalanx of middle-finger" ; owl:deprecated true . obo:HP_0004180 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the distal phalanx of the third finger." ; oboInOwl:hasAlternativeId "HP:0004182" ; oboInOwl:hasDbXref "UMLS:C4021681" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 3rd finger", "Short distal phalanx of the third finger", "Short outermost bone of the middle finger", "Short terminal phalanx of middle finger" ; oboInOwl:id "HP:0004180" ; a owl:Class ; rdfs:label "Short distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009421, obo:HP_0009461, obo:HP_0009882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004183 oboInOwl:consider "HP:0009357" ; oboInOwl:id "HP:0004183" ; a owl:Class ; rdfs:label "obsolete Abnormality of the epiphyses of the terminal phalanx of the middle finger" ; owl:deprecated true . obo:HP_0004184 oboInOwl:consider "HP:0009423" ; oboInOwl:id "HP:0004184" ; a owl:Class ; rdfs:label "obsolete Cone-shaped epiphysis of terminal phalanx of the middle finger" ; owl:deprecated true . obo:HP_0004185 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004185" ; a owl:Class ; rdfs:label "obsolete Fused epiphysis of terminal phalanx of the middle finger" ; owl:deprecated true . obo:HP_0004186 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004186" ; a owl:Class ; rdfs:label "obsolete Large epiphysis of terminal phalanx of the middle finger" ; owl:deprecated true . obo:HP_0004187 oboInOwl:consider "HP:0009316" ; oboInOwl:id "HP:0004187" ; a owl:Class ; rdfs:label "obsolete Prematurely fused epiphysis of terminal phalanx of the middle finger" ; owl:deprecated true . obo:HP_0004188 oboInOwl:hasDbXref "UMLS:C4021680" ; oboInOwl:hasExactSynonym "Abnormality of the 4th finger", "Abnormality of the ring finger" ; oboInOwl:id "HP:0004188" ; a owl:Class ; rdfs:label "Abnormal 4th finger morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004192 obo:IAO_0100001 "HP:0009394" ; oboInOwl:id "HP:0004192" ; a owl:Class ; rdfs:label "obsolete Bracket epiphyses of the 4th finger" ; owl:deprecated true . obo:HP_0004193 oboInOwl:consider "HP:0009172" ; oboInOwl:id "HP:0004193" ; a owl:Class ; rdfs:label "obsolete Expanded phalanges of the ring finger" ; owl:deprecated true . obo:HP_0004194 oboInOwl:consider "HP:0009408" ; oboInOwl:id "HP:0004194" ; a owl:Class ; rdfs:label "obsolete Hypoplastic phalanges of the ring finger" ; owl:deprecated true . obo:HP_0004195 obo:IAO_0000115 "Osteolytic defects of the phalanges of the 4th (ring) finger." ; oboInOwl:hasDbXref "UMLS:C4020832", "UMLS:C4025409" ; oboInOwl:hasRelatedSynonym "Lytic defects of the phalanges of the ring finger" ; oboInOwl:id "HP:0004195" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004196 oboInOwl:consider "HP:0009408" ; oboInOwl:id "HP:0004196" ; a owl:Class ; rdfs:label "obsolete Short phalanges of the ring finger" ; owl:deprecated true . obo:HP_0004197 obo:IAO_0000115 "Fusion of two or more bones of the 4th finger." ; oboInOwl:hasDbXref "UMLS:C4021679" ; oboInOwl:hasExactSynonym "Fused ring finger bones", "Symphalangism of the ring finger" ; oboInOwl:id "HP:0004197" ; a owl:Class ; rdfs:label "Symphalangism of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009700, obo:HP_0009773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004198 oboInOwl:consider "HP:0009172" ; oboInOwl:id "HP:0004198" ; a owl:Class ; rdfs:label "obsolete Wide/broad phalanges of the ring finger" ; owl:deprecated true . obo:HP_0004201 obo:IAO_0100001 "HP:0009310" ; oboInOwl:id "HP:0004201" ; a owl:Class ; rdfs:label "obsolete Expanded proximal phalanx of the ring finger" ; owl:deprecated true . obo:HP_0004202 obo:IAO_0100001 "HP:0009312" ; oboInOwl:id "HP:0004202" ; a owl:Class ; rdfs:label "obsolete Lytic defects of the proximal phalanx of the ring finger" ; owl:deprecated true . obo:HP_0004203 obo:IAO_0100001 "HP:0009300" ; oboInOwl:id "HP:0004203" ; a owl:Class ; rdfs:label "obsolete Short proximal phalanx of the ring finger" ; owl:deprecated true . obo:HP_0004207 obo:IAO_0000115 "An abnormality affecting one or both 5th fingers." ; oboInOwl:hasDbXref "UMLS:C4021678" ; oboInOwl:hasExactSynonym "Abnormality of the 5th finger", "Abnormality of the little finger", "Abnormality of the pinkie finger", "Abnormality of the pinky finger" ; oboInOwl:id "HP:0004207" ; a owl:Class ; rdfs:label "Abnormal 5th finger morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004209 obo:IAO_0000115 "Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger)." ; oboInOwl:hasAlternativeId "HP:0001158", "HP:0001588", "HP:0004212", "HP:0006083", "HP:0006181", "HP:0009181" ; oboInOwl:hasBroadSynonym "Curvature of little finger", "Curvature of pinkie finger", "Curvature of pinky finger" ; oboInOwl:hasDbXref "UMLS:C1850049", "UMLS:C4280538" ; oboInOwl:hasExactSynonym "Bilateral fifth digit clinodactyly", "Bilateral fifth finger clinodactyly", "Clinodactyly of fifth digit", "Clinodactyly of the little finger", "Fifth finger clinodactyly", "Permanent curving of the pinkie finger" ; oboInOwl:id "HP:0004209" ; a owl:Class ; rdfs:comment "Minor degrees of curvature of the small finger are so common as to be considered normal." ; rdfs:label "Clinodactyly of the 5th finger" ; rdfs:subClassOf obo:HP_0009179, obo:HP_0040019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004213 obo:IAO_0000115 "Abnormality of the phalanges of the 5th (little) finger." ; oboInOwl:hasDbXref "UMLS:C4025408" ; oboInOwl:hasExactSynonym "Abnormality of the little finger bone", "Abnormality of the phalanges of the 5th finger", "Abnormality of the pinkie finger bone", "Abnormality of the pinky finger bone" ; oboInOwl:id "HP:0004213" ; a owl:Class ; rdfs:label "Abnormal 5th finger phalanx morphology" ; rdfs:subClassOf obo:HP_0004207, obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004214 obo:IAO_0000115 "Curved phalanges of the 5th (little) finger." ; oboInOwl:hasDbXref "UMLS:C4025407" ; oboInOwl:hasExactSynonym "Curved little finger bone", "Curved pinkie finger bone", "Curved pinky finger bone" ; oboInOwl:id "HP:0004214" ; a owl:Class ; rdfs:label "Curved phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004095, obo:HP_0004213, obo:HP_0009770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004216 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the phalanges of the 5th finger." ; oboInOwl:hasDbXref "UMLS:C4021677" ; oboInOwl:hasExactSynonym "Lytic defects of the phalanges of the little finger" ; oboInOwl:id "HP:0004216" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004218 obo:IAO_0000115 "Fusion of two or more bones of the 5th finger." ; oboInOwl:hasDbXref "UMLS:C4021676" ; oboInOwl:hasExactSynonym "Fifth finger symphalangism", "Fused little finger bones", "Fused pinkie finger bones", "Fused pinky finger bones", "Symphalagism of the little finger" ; oboInOwl:id "HP:0004218" ; a owl:Class ; rdfs:label "Symphalangism of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009700, obo:HP_0009773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004219 oboInOwl:hasDbXref "UMLS:C4025406" ; oboInOwl:hasExactSynonym "Abnormality of the middle bone of little finger", "Abnormality of the middle bone of pinkie finger", "Abnormality of the middle bone of pinky finger" ; oboInOwl:id "HP:0004219" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004213 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004220 obo:IAO_0000115 "Hypoplastic/small middle phalanx of the fifth finger." ; oboInOwl:hasAlternativeId "HP:0001243", "HP:0003069", "HP:0004221", "HP:0005649", "HP:0005706", "HP:0005734", "HP:0005813" ; oboInOwl:hasDbXref "UMLS:C1834060" ; oboInOwl:hasExactSynonym "5th finger middle phalangeal hypoplasia", "Brachymesophalangism V", "Brachymesophalangy V (finger)", "Fifth finger mid-phalanx hypoplasia", "Hypoplastic fifth finger middle phalanx", "Hypoplastic middle phalanx of the 5th finger", "Hypoplastic/small middle phalanx of the 5th finger", "Hypoplastic/small middle phalanx of the little finger", "Short middle bone of the little finger", "Short middle bone of the pinkie finger", "Short middle bone of the pinky finger", "Short middle phalanx of the little finger", "Type A3 brachydactyly" ; oboInOwl:id "HP:0004220" ; a owl:Class ; rdfs:comment "Brachymesophalangia-V, a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3)." ; rdfs:label "Short middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0005819, obo:HP_0009161, obo:HP_0009237, obo:HP_0009370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004222 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the distal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; oboInOwl:hasDbXref "UMLS:C4021675" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost little finger bone", "Cone-shaped end part of the outermost pinkie finger bone", "Cone-shaped end part of the outermost pinky finger bone", "Cone-shaped epiphysis of the distal phalanx of the little finger" ; oboInOwl:id "HP:0004222" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009384, obo:HP_0010248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004223 obo:IAO_0000115 "Sclerosis of the epiphysis of the distal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; oboInOwl:hasAlternativeId "HP:0004229" ; oboInOwl:hasDbXref "UMLS:C4021674" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost little finger bone", "Increased bone density of end part of the outermost pinkie finger bone", "Increased bone density of end part of the outermost pinky finger bone", "Ivory epiphysis of the distal phalanx of the little finger", "Ivory epiphysis of the terminal phalanx of the little finger" ; oboInOwl:id "HP:0004223" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009388, obo:HP_0010252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004224 obo:IAO_0000115 "Abnormality of the epiphysis of the middle phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." ; oboInOwl:hasDbXref "UMLS:C4025405" ; oboInOwl:hasExactSynonym "Abnormality of the end part of middle little finger bone", "Abnormality of the end part of middle pinkie finger bone", "Abnormality of the end part of middle pinky finger bone" ; oboInOwl:id "HP:0004224" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009152, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004225 obo:IAO_0000115 "Abnormality of the distal phalanx of the 5th (little) finger." ; oboInOwl:hasDbXref "UMLS:C4021673" ; oboInOwl:hasExactSynonym "Abnormality of the distal phalanx of the little finger", "Abnormality of the outermost little finger bone", "Abnormality of the outermost pinkie finger bone", "Abnormality of the outermost pinky finger bone", "Abnormality of the terminal phalanx of the little finger" ; oboInOwl:id "HP:0004225" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004213 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004226 obo:IAO_0000115 "Curved appearance of the distal phalanx of the 5th (little) finger." ; oboInOwl:hasDbXref "UMLS:C4021672" ; oboInOwl:hasExactSynonym "Curved outermost little finger bone", "Curved outermost pinkie finger bone", "Curved outermost pinky finger bone", "Curved terminal phalanx of the little finger" ; oboInOwl:id "HP:0004226" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004214, obo:HP_0004225, obo:HP_0009838 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004227 obo:IAO_0000115 "Hypoplastic/small distal phalanx of the fifth finger." ; oboInOwl:hasAlternativeId "HP:0006171" ; oboInOwl:hasDbXref "UMLS:C1836674" ; oboInOwl:hasExactSynonym "Brachytelophalangism V", "Fifth digit distal phalangeal hypoplasia", "Hypoplastic/small terminal phalanx of the little finger", "Short distal phalanx of the fifth finger", "Short outermost little finger bone", "Short outermost pinkie finger bone", "Short outermost pinky finger bone" ; oboInOwl:id "HP:0004227" ; a owl:Class ; rdfs:label "Short distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009237, obo:HP_0009239, obo:HP_0009882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004230 obo:IAO_0000115 "A partial dislocation of the proximal interphalangeal joint of the little finger." ; oboInOwl:hasDbXref "UMLS:C4025404" ; oboInOwl:hasExactSynonym "Partially dislocated innermost hinge joint of little finger", "Partially dislocated innermost hinge joint of pinkie finger", "Partially dislocated innermost hinge joint of pinky finger" ; oboInOwl:id "HP:0004230" ; a owl:Class ; rdfs:label "Subluxation of the proximal interphalangeal joint of the little finger" ; rdfs:subClassOf obo:HP_0004207, obo:HP_0032153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016426 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004231 obo:IAO_0000115 "Congenital absence of a carpal bone." ; oboInOwl:hasAlternativeId "HP:0005056", "HP:0006020", "HP:0006084" ; oboInOwl:hasBroadSynonym "Absent wrist bone", "Missing wrist bone" ; oboInOwl:hasDbXref "UMLS:C1836219", "UMLS:C4280537" ; oboInOwl:hasExactSynonym "Absent carpal bone", "Absent carpal bones", "Absent carpal ossification center", "Absent carpal ossification centre", "Aplastic carpal bone" ; oboInOwl:id "HP:0004231" ; a owl:Class ; rdfs:comment "Radiographically difficult to distinguish between absent ossification of a carpal bone." ; rdfs:label "Carpal bone aplasia" ; rdfs:subClassOf obo:HP_0006502 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004232 obo:IAO_0000115 "The presence of more than the normal number of carpal bones." ; oboInOwl:hasBroadSynonym "Extra wrist bones" ; oboInOwl:hasDbXref "SNOMEDCT_US:20136007", "SNOMEDCT_US:9181003", "UMLS:C0265609" ; oboInOwl:hasExactSynonym "Supernumerary carpal bones" ; oboInOwl:id "HP:0004232" ; a owl:Class ; rdfs:label "Accessory carpal bones" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0004275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004233 obo:IAO_0000115 "Ossification of carpal bones at an abnormally early age." ; oboInOwl:hasAlternativeId "HP:0006104" ; oboInOwl:hasBroadSynonym "Accelerated wrist bone maturation" ; oboInOwl:hasDbXref "UMLS:C1849292", "UMLS:C4280536" ; oboInOwl:hasExactSynonym "Accelerated carpal bone maturation", "Advanced carpal bone age", "Advanced carpal ossification", "Precociously ossified carpal bones" ; oboInOwl:id "HP:0004233" ; a owl:Class ; rdfs:label "Advanced ossification of carpal bones" ; rdfs:subClassOf obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004234 obo:IAO_0000115 "The bone-in-bone sign is a radiographic finding produced by increased sclerosis (abnormally dense bone) occurring intermittently with zones of relatively normal bone density. This term should be used to describe such a finding in the carpal bones." ; oboInOwl:hasBroadSynonym "Bone-in-a-bone appearance of wrist bones" ; oboInOwl:hasDbXref "UMLS:C4025403" ; oboInOwl:id "HP:0004234" ; a owl:Class ; rdfs:label "Bone-in-a-bone appearance of carpal bones" ; rdfs:subClassOf obo:HP_0009164, obo:HP_0011001 . obo:HP_0004235 oboInOwl:hasBroadSynonym "Comma-shaped wrist bones" ; oboInOwl:hasDbXref "UMLS:C4025402" ; oboInOwl:id "HP:0004235" ; a owl:Class ; rdfs:label "Comma-shaped carpal bones" ; rdfs:subClassOf obo:HP_0006014 . obo:HP_0004236 obo:IAO_0000115 "Carpal bones with irregular or fragmented margins." ; oboInOwl:hasBroadSynonym "Irregular wrist bones" ; oboInOwl:hasDbXref "UMLS:C4025401" ; oboInOwl:id "HP:0004236" ; a owl:Class ; rdfs:label "Irregular carpal bones" ; rdfs:subClassOf obo:HP_0006014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004237 obo:IAO_0000115 "Increased size of carpal bones." ; oboInOwl:hasBroadSynonym "Large wrist bones" ; oboInOwl:hasDbXref "UMLS:C4021671" ; oboInOwl:hasExactSynonym "Large carpals" ; oboInOwl:id "HP:0004237" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Large carpal bones" ; rdfs:subClassOf obo:HP_0006014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004238 oboInOwl:hasDbXref "UMLS:C4025400" ; oboInOwl:id "HP:0004238" ; a owl:Class ; rdfs:label "Lytic defects of carpal bones" ; rdfs:subClassOf obo:HP_0001495 . obo:HP_0004239 oboInOwl:hasDbXref "UMLS:C4025399" ; oboInOwl:id "HP:0004239" ; a owl:Class ; rdfs:label "Proximally placed carpal bones" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002179 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004240 oboInOwl:hasBroadSynonym "Hardened spots within wrist bones", "Stiffened spots within wrist bones" ; oboInOwl:hasDbXref "UMLS:C4025398", "UMLS:C4280535" ; oboInOwl:id "HP:0004240" ; a owl:Class ; rdfs:label "Sclerotic foci within carpal bones" ; rdfs:subClassOf obo:HP_0004054, obo:HP_0009164 . obo:HP_0004241 obo:IAO_0000115 "Point-shaped (punctate) calcifications affecting the carpal bones." ; oboInOwl:hasAlternativeId "HP:0006177" ; oboInOwl:hasDbXref "UMLS:C1844846" ; oboInOwl:hasExactSynonym "Punctate calcifications of carpals" ; oboInOwl:id "HP:0004241" ; a owl:Class ; rdfs:label "Stippled calcification in carpal bones" ; rdfs:subClassOf obo:HP_0004054, obo:HP_0009164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0004242 oboInOwl:hasBroadSynonym "Wide wrist bones" ; oboInOwl:hasDbXref "UMLS:C3554618" ; oboInOwl:hasExactSynonym "Wide carpal bones" ; oboInOwl:id "HP:0004242" ; a owl:Class ; rdfs:label "Broad carpal bones" ; rdfs:subClassOf obo:HP_0004237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004243 oboInOwl:hasDbXref "UMLS:C4025397" ; oboInOwl:id "HP:0004243" ; a owl:Class ; rdfs:label "Abnormality of the scaphoid" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004244 oboInOwl:hasDbXref "UMLS:C4025396" ; oboInOwl:id "HP:0004244" ; a owl:Class ; rdfs:label "Accessory scaphoid" ; rdfs:subClassOf obo:HP_0004232, obo:HP_0004243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004245 oboInOwl:hasDbXref "UMLS:C4025395" ; oboInOwl:id "HP:0004245" ; a owl:Class ; rdfs:label "Comma-shaped scaphoid" ; rdfs:subClassOf obo:HP_0004235, obo:HP_0004243 . obo:HP_0004246 obo:IAO_0000115 "Formation of bone tissue of scaphoid is less than expected for age." ; oboInOwl:hasDbXref "UMLS:C4021670" ; oboInOwl:hasExactSynonym "Delayed maturation of the scaphoid" ; oboInOwl:id "HP:0004246" ; a owl:Class ; rdfs:label "Delayed ossification of the scaphoid" ; rdfs:subClassOf obo:HP_0001216, obo:HP_0045003 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001427 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004247 obo:IAO_0000115 "Underdevelopment of the scaphoid." ; oboInOwl:hasDbXref "UMLS:C4025394" ; oboInOwl:id "HP:0004247" ; a owl:Class ; rdfs:label "Small scaphoid" ; rdfs:subClassOf obo:HP_0001498, obo:HP_0004243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004248 oboInOwl:hasDbXref "UMLS:C4025393" ; oboInOwl:id "HP:0004248" ; a owl:Class ; rdfs:label "Abnormality of the lunate bone" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001428 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004249 oboInOwl:hasDbXref "UMLS:C4025392" ; oboInOwl:id "HP:0004249" ; a owl:Class ; rdfs:label "Accessory lunate" ; rdfs:subClassOf obo:HP_0004232, obo:HP_0004248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001428 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004250 oboInOwl:hasDbXref "UMLS:C4025391" ; oboInOwl:id "HP:0004250" ; a owl:Class ; rdfs:label "Proximally placed lunate" ; rdfs:subClassOf obo:HP_0004239, obo:HP_0004248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002179 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001428 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004251 obo:IAO_0000115 "Osseous fusion of the lunate and triquetrum." ; oboInOwl:hasDbXref "UMLS:C1867930" ; oboInOwl:hasExactSynonym "Lunotriquetral synostosis" ; oboInOwl:id "HP:0004251" ; a owl:Class ; rdfs:comment "Synostosis of the carpal bones is a rare congenital condition. Lunate and triquetrum are the bones more commonly involved." ; rdfs:label "Lunate-triquetral fusion" ; rdfs:subClassOf obo:HP_0004248 . obo:HP_0004252 obo:IAO_0000115 "An anomaly of trapezium." ; oboInOwl:hasDbXref "UMLS:C4025390" ; oboInOwl:id "HP:0004252" ; a owl:Class ; rdfs:label "Abnormality of the trapezium" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001430 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004253 oboInOwl:hasDbXref "UMLS:C1847190" ; oboInOwl:hasExactSynonym "Absent trapezium bone" ; oboInOwl:id "HP:0004253" ; a owl:Class ; rdfs:label "Absent trapezium" ; rdfs:subClassOf obo:HP_0004252, obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001430 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004254 obo:IAO_0000115 "Formation of bone tissue of trapezium is less than expected for age." ; oboInOwl:hasDbXref "UMLS:C4021669" ; oboInOwl:hasExactSynonym "Delayed maturation of the trapezium" ; oboInOwl:id "HP:0004254" ; a owl:Class ; rdfs:label "Delayed ossification of the trapezium" ; rdfs:subClassOf obo:HP_0001216, obo:HP_0045001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001430 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004255 obo:IAO_0000115 "Underdevelopment of the trapezium." ; oboInOwl:hasDbXref "UMLS:C4025389" ; oboInOwl:id "HP:0004255" ; a owl:Class ; rdfs:label "Small trapezium" ; rdfs:subClassOf obo:HP_0001498, obo:HP_0004252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001430 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004256 oboInOwl:hasDbXref "UMLS:C4025388" ; oboInOwl:id "HP:0004256" ; a owl:Class ; rdfs:label "Abnormality of the trapezoid bone" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004257 obo:IAO_0000115 "Formation of bone tissue of trapezoid is less than expected for age." ; oboInOwl:hasDbXref "UMLS:C4021668" ; oboInOwl:hasExactSynonym "Delayed maturation of the trapezoid bone" ; oboInOwl:id "HP:0004257" ; a owl:Class ; rdfs:label "Delayed ossification of the trapezoid bone" ; rdfs:subClassOf obo:HP_0001216, obo:HP_0045004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001431 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004258 obo:IAO_0000115 "Underdevelopment of the trapezoid." ; oboInOwl:hasDbXref "UMLS:C4025387" ; oboInOwl:id "HP:0004258" ; a owl:Class ; rdfs:label "Small trapezoid bone" ; rdfs:subClassOf obo:HP_0001498, obo:HP_0004256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004259 oboInOwl:hasDbXref "UMLS:C4025386" ; oboInOwl:id "HP:0004259" ; a owl:Class ; rdfs:label "Abnormality of the hamate bone" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001433 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004260 oboInOwl:hasDbXref "UMLS:C4025385" ; oboInOwl:hasExactSynonym "Large unciform bone" ; oboInOwl:id "HP:0004260" ; a owl:Class ; rdfs:label "Large hamate bone" ; rdfs:subClassOf obo:HP_0004237, obo:HP_0004259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001433 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004261 oboInOwl:hasDbXref "UMLS:C4021667" ; oboInOwl:hasExactSynonym "Broad hamate bone", "Wide unciform bone" ; oboInOwl:id "HP:0004261" ; a owl:Class ; rdfs:label "Wide hamate bone" ; rdfs:subClassOf obo:HP_0004242, obo:HP_0004260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001433 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004262 oboInOwl:hasDbXref "UMLS:C4025384" ; oboInOwl:id "HP:0004262" ; a owl:Class ; rdfs:label "Abnormality of the capitate bone" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001432 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004263 oboInOwl:hasDbXref "UMLS:C4025383" ; oboInOwl:id "HP:0004263" ; a owl:Class ; rdfs:label "Large capitate bone" ; rdfs:subClassOf obo:HP_0004237, obo:HP_0004262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001432 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004264 oboInOwl:hasAlternativeId "HP:0004265" ; oboInOwl:hasDbXref "UMLS:C4021666" ; oboInOwl:hasExactSynonym "Decreased carpal joint angles" ; oboInOwl:id "HP:0004264" ; a owl:Class ; rdfs:label "Narrow carpal joint spaces" ; rdfs:subClassOf obo:HP_0001191 . obo:HP_0004267 oboInOwl:hasDbXref "UMLS:C4025382" ; oboInOwl:hasExactSynonym "Narrow small joints of the hand" ; oboInOwl:id "HP:0004267" ; a owl:Class ; rdfs:label "Narrow small joints of the hand" ; rdfs:subClassOf obo:HP_0006261 . obo:HP_0004268 oboInOwl:hasDbXref "UMLS:C4025381" ; oboInOwl:id "HP:0004268" ; a owl:Class ; rdfs:label "Osteoarthritis of the small joints of the hand" ; rdfs:subClassOf obo:HP_0002758, obo:HP_0006261 . obo:HP_0004269 obo:IAO_0000115 "A partial dislocation of some or all of the small joints of the hand." ; oboInOwl:hasDbXref "UMLS:C4025380" ; oboInOwl:hasExactSynonym "Partial dislocation of small joints of hand" ; oboInOwl:id "HP:0004269" ; a owl:Class ; rdfs:label "Subluxation of the small joints of the hand" ; rdfs:subClassOf obo:HP_0006261, obo:HP_0032153 . obo:HP_0004271 oboInOwl:hasDbXref "UMLS:C4025379" ; oboInOwl:id "HP:0004271" ; a owl:Class ; rdfs:label "Cortical thickening of hand bones" ; rdfs:subClassOf obo:HP_0005926, obo:HP_0100039 . obo:HP_0004272 oboInOwl:hasDbXref "UMLS:C4025378" ; oboInOwl:id "HP:0004272" ; a owl:Class ; rdfs:label "Cortical thinning of hand bones" ; rdfs:subClassOf obo:HP_0002753, obo:HP_0005926 . obo:HP_0004273 oboInOwl:hasDbXref "UMLS:C4025377" ; oboInOwl:hasExactSynonym "Cupped metaphysis of hand bones", "Cupped wide portion of hand bones" ; oboInOwl:id "HP:0004273" ; a owl:Class ; rdfs:label "Cupped metaphyses of hand bones" ; rdfs:subClassOf obo:HP_0005923 . obo:HP_0004274 oboInOwl:hasDbXref "UMLS:C4025376", "UMLS:C4280534" ; oboInOwl:hasRelatedSynonym "Deficient maturation of hand bones" ; oboInOwl:id "HP:0004274" ; a owl:Class ; rdfs:label "Deficient ossification of hand bones" ; rdfs:subClassOf obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004275 oboInOwl:hasDbXref "UMLS:C3276746" ; oboInOwl:hasExactSynonym "Duplication of hand bones" ; oboInOwl:id "HP:0004275" ; a owl:Class ; rdfs:label "Duplication of hand bones" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0009142 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004276 obo:IAO_0000115 "Abnormal formation of new bone on the surface of a bone of the hand." ; oboInOwl:hasDbXref "UMLS:C4025375" ; oboInOwl:id "HP:0004276" ; a owl:Class ; rdfs:label "Exostoses of hand bones" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0100777 . obo:HP_0004277 oboInOwl:hasAlternativeId "HP:0041232" ; oboInOwl:hasDbXref "SNOMEDCT_US:20511007", "UMLS:C0435632" ; oboInOwl:hasExactSynonym "Broken hand bones", "Fractured hand bones" ; oboInOwl:id "HP:0004277" ; a owl:Class ; rdfs:label "Fractured hand bones" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004278 obo:IAO_0000115 "An abnormal union between bones or parts of bones of the hand." ; oboInOwl:hasDbXref "UMLS:C4020831" ; oboInOwl:hasRelatedSynonym "Fused hand bones" ; oboInOwl:id "HP:0004278" ; a owl:Class ; rdfs:label "Synostosis involving bones of the hand" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0100238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004279 obo:IAO_0000115 "Short palm." ; oboInOwl:hasAlternativeId "HP:0001165" ; oboInOwl:hasDbXref "UMLS:C1843108" ; oboInOwl:hasExactSynonym "Short palm" ; oboInOwl:hasRelatedSynonym "Hypoplastic hands", "Short hands", "Short palms" ; oboInOwl:id "HP:0004279" ; a owl:Class ; rdfs:comment "This term refers to a developmental finding resulting in short palms. This term is reserved for individuals with shortening of all four metacarpals 2-5. Individuals with fewer than four shortened metacarpals (in a eudactylous hand, the metacarpals of F2-5) should be coded as Metacarpal, short. See the entry for Hand, small for a discussion of this finding. \"Short hand\" should not be used as it is a bundle of two readily separable terms, Fingers, short (which, as noted above, can itself be a bundled term) and Palm, short." ; rdfs:label "Short palm" ; rdfs:subClassOf obo:HP_0005927, obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004280 oboInOwl:hasDbXref "UMLS:C4025374" ; oboInOwl:hasRelatedSynonym "Irregular maturation of hand bones" ; oboInOwl:id "HP:0004280" ; a owl:Class ; rdfs:label "Irregular ossification of hand bones" ; rdfs:subClassOf obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004281 oboInOwl:hasDbXref "UMLS:C4025373" ; oboInOwl:id "HP:0004281" ; a owl:Class ; rdfs:label "Irregular sclerosis of hand bones" ; rdfs:subClassOf obo:HP_0004054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0004054 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004283 obo:IAO_0000115 "For children from birth to 4 years of age, the palm width is more than 2 SD below the mean; for children from 4 to 16 years of age the palm width is below the 5th centile; or, the width of the palm appears disproportionately narrow for its length." ; oboInOwl:hasDbXref "UMLS:C1857632" ; oboInOwl:hasExactSynonym "Narrow hand", "Narrow palm" ; oboInOwl:hasRelatedSynonym "Narrow hands" ; oboInOwl:id "HP:0004283" ; a owl:Class ; rdfs:comment "Palm width is measured across the palm at the level of the MCPJ (radial aspect of the F2 MCPJ to the ulnar aspect of the F5 MCPJ). Norms are specified in [Hall et al., 2007]. Caution is advised for the subjective assessment as the breadth may be in the normal range with disproportionately increased length, which appears narrow. This finding may be associated with elongated/slender limbs in general, but that finding does not bear on the coding of this feature. Proximal narrowing may indicate small thenar or hypothenar eminences. This term replaces \"narrow hands\" as that term may leave the impression that it includes the thumb, which it does not." ; rdfs:label "Narrow palm" ; rdfs:subClassOf obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004284 oboInOwl:hasDbXref "UMLS:C4025372" ; oboInOwl:hasExactSynonym "Notched hand bones" ; oboInOwl:id "HP:0004284" ; a owl:Class ; rdfs:label "Notched hand bones" ; rdfs:subClassOf obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001495 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004285 oboInOwl:hasDbXref "UMLS:C4025371" ; oboInOwl:id "HP:0004285" ; a owl:Class ; rdfs:label "Overmodelled hand bones" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0004286 oboInOwl:hasDbXref "UMLS:C4025370" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in hand bones" ; oboInOwl:id "HP:0004286" ; a owl:Class ; rdfs:label "Patchy sclerosis of hand bones" ; rdfs:subClassOf obo:HP_0004281 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0004287 oboInOwl:hasDbXref "UMLS:C4025369" ; oboInOwl:hasExactSynonym "Pointed hand bones" ; oboInOwl:id "HP:0004287" ; a owl:Class ; rdfs:label "Pointed hand bones" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0004288 oboInOwl:hasDbXref "UMLS:C4025368" ; oboInOwl:id "HP:0004288" ; a owl:Class ; rdfs:label "Pseudoepiphyses of hand bones" ; rdfs:subClassOf obo:HP_0005924, obo:HP_0010584 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004289 oboInOwl:hasDbXref "UMLS:C4025367" ; oboInOwl:id "HP:0004289" ; a owl:Class ; rdfs:label "Sclerotic foci in hand bones" ; rdfs:subClassOf obo:HP_0004281 . obo:HP_0004290 oboInOwl:hasDbXref "UMLS:C4025366" ; oboInOwl:id "HP:0004290" ; a owl:Class ; rdfs:label "Sclerosis of hand bones with transverse striations" ; rdfs:subClassOf obo:HP_0004281 . obo:HP_0004291 oboInOwl:hasDbXref "UMLS:C4025365" ; oboInOwl:id "HP:0004291" ; a owl:Class ; rdfs:label "Stippled calcification of hand bones" ; rdfs:subClassOf obo:HP_0004280 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005897 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0004292 oboInOwl:hasDbXref "UMLS:C4025364" ; oboInOwl:id "HP:0004292" ; a owl:Class ; rdfs:label "Undermodelled hand bones" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0004293 obo:IAO_0000115 "Fusion of the second metacarpal-trapezoid." ; oboInOwl:hasDbXref "UMLS:C4021665" ; oboInOwl:hasExactSynonym "Fusion of second metacarpal-trapezoid" ; oboInOwl:id "HP:0004293" ; a owl:Class ; rdfs:label "Synostosis of second metacarpal-trapezoid" ; rdfs:subClassOf obo:HP_0009705, obo:HP_0100328 . obo:HP_0004294 obo:IAO_0000115 "A partial dislocation affecting some or all of the metacarpophalangeal joints." ; oboInOwl:hasDbXref "UMLS:C4025363" ; oboInOwl:hasExactSynonym "Partial knuckle dislocation", "Subluxation of metacarpophalangeal joints" ; oboInOwl:id "HP:0004294" ; a owl:Class ; rdfs:label "Subluxation of metacarpal phalangeal joints" ; rdfs:subClassOf obo:HP_0011911, obo:HP_0032153 . obo:HP_0004295 obo:IAO_0000115 "An abnormality of the gastric mucous membrane." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:12:00Z" ; oboInOwl:hasDbXref "UMLS:C4025362" ; oboInOwl:hasExactSynonym "Abnormality of the gastric mucosa", "Abnormality of the mucous membrane layer of stomach" ; oboInOwl:id "HP:0004295" ; a owl:Class ; rdfs:label "Abnormal gastric mucosa morphology" ; rdfs:subClassOf obo:HP_0002577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004296 dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:24:00Z" ; oboInOwl:hasDbXref "UMLS:C4025361" ; oboInOwl:hasExactSynonym "Abnormality of GI blood vessels", "Abnormality of GI vasculature", "Abnormality of gastrointestinal vasculature" ; oboInOwl:id "HP:0004296" ; a owl:Class ; rdfs:label "Abnormal gastrointestinal vascular morphology" ; rdfs:subClassOf obo:HP_0012718, obo:HP_0025015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004297 obo:IAO_0000115 "An abnormality of the biliary system." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:34:00Z" ; oboInOwl:hasDbXref "UMLS:C0940767" ; oboInOwl:id "HP:0004297" ; a owl:Class ; rdfs:label "Abnormality of the biliary system" ; rdfs:subClassOf obo:HP_0001392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002294 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004298 obo:IAO_0000115 "The presence of any abnormality affecting the abdominal wall." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:40:00Z" ; oboInOwl:hasAlternativeId "HP:0001462" ; oboInOwl:hasDbXref "UMLS:C4021664" ; oboInOwl:hasExactSynonym "Abnormality of external features of the abdomen", "Abnormality of the abdominal wall" ; oboInOwl:id "HP:0004298" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the abdominal wall" ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004299 obo:IAO_0000115 "The presence of a hernia in the abdominal wall." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:42:00Z" ; oboInOwl:hasDbXref "Fyler:4414", "SNOMEDCT_US:128545000", "UMLS:C1442978" ; oboInOwl:hasExactSynonym "Herniated abdominal wall" ; oboInOwl:id "HP:0004299" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A hernia refers to a sac formed by the lining of the abdominal cavity (peritoneum). The sac can protrude through a hole or weak area in the abdominal fascia." ; rdfs:label "Hernia of the abdominal wall" ; rdfs:subClassOf obo:HP_0010866, obo:HP_0100790 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000643 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004302 dcterms:creator ; oboInOwl:creation_date "2008-02-20T11:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4025360" ; oboInOwl:hasExactSynonym "Functional motor problems" ; oboInOwl:id "HP:0004302" ; a owl:Class ; rdfs:label "Functional motor deficit" ; rdfs:subClassOf obo:HP_0011804 . obo:HP_0004303 obo:IAO_0000115 "Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T12:04:00Z" ; oboInOwl:hasAlternativeId "HP:0003706", "HP:0011806" ; oboInOwl:hasDbXref "UMLS:C4021663" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre morphology", "Abnormal skeletal muscle fiber morphology", "Abnormal skeletal muscle fibre morphology", "Abnormality of muscle fibers", "Abnormality of muscle fibres" ; oboInOwl:id "HP:0004303" ; a owl:Class ; rdfs:comment "Normal human muscle is composed of many individual muscle fibers bundled together by layers of connective tissue that are arranged in a nesting-doll like fashion. The inner most structure, the single muscle fiber, is covered by a thin layer of primarily reticular fibers called the endomysium. The endomysium is quite inconspicuous and muscle fibers appear to be in direct contact with each other. The finest capillaries, nerve twigs and lymphatic capillaries are found within the endomysium. Groups of muscle fibers are bound together by the thicker perimysium, forming structures called fascicles. Capillaries, nerve fibers and lymphatic vessels also track in the perimyseum. Bundles of fascicles are encased within the dense irregular connective tissue of the epimysium. These connective tissue layers provide mechanical protection for the muscle fibers and increase the tensile strength of the muscle. The layers are continuous with the tendon, which provides attachment to bone. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5 percent of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei. Each nucleus provides a segment of the cell with needed translated protein products." ; rdfs:label "Abnormal muscle fiber morphology" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000188 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004305 obo:IAO_0000115 "Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T12:18:00Z" ; oboInOwl:hasAlternativeId "HP:0007120" ; oboInOwl:hasDbXref "SNOMEDCT_US:102542000", "UMLS:C0235086" ; oboInOwl:hasExactSynonym "Involuntary movements", "Involuntary muscle contractions" ; oboInOwl:id "HP:0004305" ; a owl:Class ; rdfs:label "Involuntary movements" ; rdfs:subClassOf obo:HP_0011442, obo:HP_0100022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0003010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004306 obo:IAO_0000115 "An abnormality of the endocardium." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T01:23:00Z" ; oboInOwl:hasAlternativeId "HP:0005260" ; oboInOwl:hasDbXref "UMLS:C4021662" ; oboInOwl:hasExactSynonym "Abnormality of the endocardium", "Abnormality of the endomycoardium" ; oboInOwl:id "HP:0004306" ; a owl:Class ; rdfs:label "Abnormal endocardium morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004307 obo:IAO_0000115 "Developmental defect characterized by an anomalous anatomic location of the heart." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T01:23:00Z" ; oboInOwl:hasDbXref "UMLS:C4025359" ; oboInOwl:id "HP:0004307" ; a owl:Class ; rdfs:label "Abnormal anatomic location of the heart" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004308 dcterms:creator ; oboInOwl:creation_date "2008-02-20T01:28:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:44103008", "UMLS:C0085612" ; oboInOwl:hasExactSynonym "Ventricular arrhythmias" ; oboInOwl:id "HP:0004308" ; a owl:Class ; rdfs:label "Ventricular arrhythmia" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0004309 obo:IAO_0000115 "An abnormality in which the cardiac ventricles depolarize too early as a result of an abnormality of cardiac conduction pathways such as an accessory pathway." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T01:29:00Z" ; oboInOwl:hasAlternativeId "HP:0006676" ; oboInOwl:hasDbXref "SNOMEDCT_US:195060002", "UMLS:C0559106" ; oboInOwl:hasExactSynonym "Pre-excitation syndrome", "Preexcitation", "Ventricular pre-excitation" ; oboInOwl:id "HP:0004309" ; a owl:Class ; rdfs:comment "Pre-excitation syndromes are generally caused by accelerated conduction along an accessory pathway, but in some cases there is accelerated conduction through the normal AV node." ; rdfs:label "Ventricular preexcitation" ; rdfs:subClassOf obo:HP_0004308 . obo:HP_0004311 obo:IAO_0000115 "An abnormality of macrophages." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T03:14:00Z" ; oboInOwl:hasAlternativeId "HP:0004310" ; oboInOwl:hasDbXref "UMLS:C4021661" ; oboInOwl:hasExactSynonym "Abnormality of histiocytes", "Abnormality of macrophages" ; oboInOwl:id "HP:0004311" ; a owl:Class ; rdfs:label "Abnormal macrophage morphology" ; rdfs:subClassOf obo:HP_0010974 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004312 obo:IAO_0000115 "A reticulocyte abnormality." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T03:19:00Z" ; oboInOwl:hasDbXref "UMLS:C4025358" ; oboInOwl:hasExactSynonym "Abnormality of reticulocytes" ; oboInOwl:id "HP:0004312" ; a owl:Class ; rdfs:comment "Reticulocytes are immature erythrocytes that show a basophilic reticulum under vital staining." ; rdfs:label "Abnormal reticulocyte morphology" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0002422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004313 obo:IAO_0000115 "An abnormally decreased level of immunoglobulin in blood." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T03:34:00Z" ; oboInOwl:hasAlternativeId "HP:0010703" ; oboInOwl:hasDbXref "MSH:D000361", "SNOMEDCT_US:119250001", "UMLS:C0086438", "UMLS:C4048270" ; oboInOwl:hasExactSynonym "Decreased antibody level in blood", "Decreased immunoglobulin level", "Decreased serum immunoglobulin", "Hypogammaglobulinemia", "Immunoglobulin deficiency", "Reduced immunoglobulin levels" ; oboInOwl:id "HP:0004313" ; a owl:Class ; rdfs:comment "In humans, immunoglobulins comprise the five antibody isotypes IgA, IgD, IgE, IgG and IgM." ; rdfs:label "Decreased circulating antibody level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042571 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004315 obo:IAO_0000115 "An abnormally decreased level of immunoglobulin G (IgG) in blood." ; dcterms:creator ; oboInOwl:creation_date "2008-02-20T03:43:00Z" ; oboInOwl:hasAlternativeId "HP:0003289", "HP:0003294", "HP:0005394", "HP:0008325", "HP:0008340" ; oboInOwl:hasDbXref "MSH:D017099", "SNOMEDCT_US:123785006", "SNOMEDCT_US:190981001", "UMLS:C0162539" ; oboInOwl:hasExactSynonym "Decreased IgG level", "Decreased IgG level in blood", "Decreased gamma-globin expression", "Decreased immunoglobulin G", "Decreased serum IgG", "IgG deficiency", "Reduced IgG levels" ; oboInOwl:id "HP:0004315" ; a owl:Class ; rdfs:label "Decreased circulating IgG level" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0410242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071736 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004319 obo:IAO_0000115 "Abnormally reduced levels of aldosterone." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T10:45:00Z" ; oboInOwl:hasAlternativeId "HP:0000355", "HP:0002924", "HP:0008184", "HP:0008190" ; oboInOwl:hasDbXref "MSH:D006994", "SNOMEDCT_US:60086000", "UMLS:C0020595", "UMLS:C0857899", "UMLS:C1846226" ; oboInOwl:hasExactSynonym "Decreased aldosterone", "Decreased aldosterone production", "Decreased serum aldosterone", "Hypoaldosteronism", "Low blood aldosterone level", "Mineralocorticoid insufficiency" ; oboInOwl:id "HP:0004319" ; a owl:Class ; rdfs:comment "Aldosterone is a hormone that is produce by the adrenal cortex and that acts on the distal tubules and collecting ducts to favor retention of sodium excretion of potassium, and increased water retention, thereby tending to increase blood pressure. Aldosterone is sometimes called a mineralocorticoid because of its influence on sodium homeostasis." ; rdfs:label "Decreased circulating aldosterone level" ; rdfs:subClassOf obo:HP_0008207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004320 obo:IAO_0000115 "The presence of a fistula of the vagina." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T12:17:00Z" ; oboInOwl:hasDbXref "MSH:D014624", "SNOMEDCT_US:45135002", "UMLS:C0042253" ; oboInOwl:id "HP:0004320" ; a owl:Class ; rdfs:label "Vaginal fistula" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0100589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004321 obo:IAO_0000115 "The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin." ; dcterms:creator ; oboInOwl:creation_date "2008-02-25T12:32:00Z" ; oboInOwl:hasDbXref "MSH:D001747", "SNOMEDCT_US:68666001", "UMLS:C0005690" ; oboInOwl:id "HP:0004321" ; a owl:Class ; rdfs:label "Bladder fistula" ; rdfs:subClassOf obo:HP_0025487, obo:HP_0100589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004322 obo:IAO_0000115 "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T03:19:00Z" ; oboInOwl:hasAlternativeId "HP:0001509", "HP:0003501", "HP:0003507", "HP:0003512", "HP:0003518", "HP:0003519", "HP:0008871", "HP:0008882", "HP:0008888", "HP:0008913" ; oboInOwl:hasDbXref "SNOMEDCT_US:237836003", "UMLS:C0349588" ; oboInOwl:hasExactSynonym "Decreased body height", "Height less than 3rd percentile", "Short stature", "Small stature", "Stature below 3rd percentile" ; oboInOwl:id "HP:0004322" ; a owl:Class ; rdfs:label "Short stature" ; rdfs:subClassOf obo:HP_0000002, obo:HP_0001510 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000569 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004323 obo:IAO_0000115 "An abnormal increase or decrease of weight or an abnormal distribution of mass in the body." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T03:21:00Z" ; oboInOwl:hasAlternativeId "HP:0010718" ; oboInOwl:hasDbXref "UMLS:C0878621", "UMLS:C4025357" ; oboInOwl:hasExactSynonym "Abnormality of body weight" ; oboInOwl:hasRelatedSynonym "Abnormality of habitus" ; oboInOwl:id "HP:0004323" ; a owl:Class ; rdfs:label "Abnormality of body weight" ; rdfs:subClassOf obo:HP_0001507 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004324 obo:IAO_0000115 "Abnormally increased body weight." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T03:21:00Z" ; oboInOwl:hasAlternativeId "HP:0045083" ; oboInOwl:hasDbXref "MSH:D015430", "SNOMEDCT_US:161831008", "SNOMEDCT_US:262286000", "SNOMEDCT_US:8943002", "UMLS:C0043094" ; oboInOwl:hasExactSynonym "Increased body weight" ; oboInOwl:hasRelatedSynonym "Weight gain" ; oboInOwl:id "HP:0004324" ; a owl:Class ; rdfs:label "Increased body weight" ; rdfs:subClassOf obo:HP_0004323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004325 obo:IAO_0000115 "Abnormally low body weight." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T03:22:00Z" ; oboInOwl:hasAlternativeId "HP:0001823", "HP:0001826" ; oboInOwl:hasDbXref "MSH:D013851", "MSH:D015431", "SNOMEDCT_US:161832001", "SNOMEDCT_US:248342006", "SNOMEDCT_US:262285001", "SNOMEDCT_US:89362005", "UMLS:C0041667", "UMLS:C1262477", "UMLS:C1844806" ; oboInOwl:hasExactSynonym "Decreased body weight", "Decreased weight", "Low body weight", "Low weight", "Weight less than 3rd percentile" ; oboInOwl:id "HP:0004325" ; a owl:Class ; rdfs:label "Decreased body weight" ; rdfs:subClassOf obo:HP_0004323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004326 obo:IAO_0000115 "Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T03:23:00Z" ; oboInOwl:hasDbXref "MSH:D002100", "SNOMEDCT_US:238108007", "SNOMEDCT_US:285384003", "UMLS:C0006625" ; oboInOwl:hasExactSynonym "Wasting syndrome" ; oboInOwl:id "HP:0004326" ; a owl:Class ; rdfs:label "Cachexia" ; rdfs:subClassOf obo:HP_0001824 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004327 obo:IAO_0000115 "Any structural anomaly of the vitreous body." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T04:20:00Z" ; oboInOwl:hasDbXref "UMLS:C4025356" ; oboInOwl:hasExactSynonym "Abnormal vitreous humour morphology" ; oboInOwl:id "HP:0004327" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The vitreous humor is the clear gel that fills the space between the lens and the retina." ; rdfs:label "Abnormal vitreous humor morphology" ; rdfs:subClassOf obo:HP_0004329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001797 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004328 obo:IAO_0000115 "An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens)." ; dcterms:creator ; oboInOwl:creation_date "2008-02-27T04:23:00Z" ; oboInOwl:hasDbXref "UMLS:C4025355" ; oboInOwl:hasExactSynonym "Abnormal anterior segment morphology", "Abnormality of the anterior segment of the eye", "Abnormality of the anterior segment of the eyeball", "Abnormality of the anterior segment of the globe" ; oboInOwl:id "HP:0004328" ; a owl:Class ; rdfs:comment "The anterior segment comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens." ; rdfs:label "Abnormal anterior eye segment morphology" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004329 dcterms:creator ; oboInOwl:creation_date "2008-02-27T04:25:00Z" ; oboInOwl:hasDbXref "UMLS:C4025354" ; oboInOwl:hasExactSynonym "Abnormal morphology of the posterior segment of the globe", "Abnormality of the posterior segment of the eye", "Abnormality of the posterior segment of the eyeball", "Abnormality of the posterior segment of the globe" ; oboInOwl:id "HP:0004329" ; a owl:Class ; rdfs:comment "The posterior segment comprises the anterior hyaloid membrane and all of the optical structures behind it: the vitreous humor, retina, choroid, and optic nerve." ; rdfs:label "Abnormal posterior eye segment morphology" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001802 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004330 obo:IAO_0000115 "An increase in the magnitude or amount of ossification of the skull." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T11:54:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:17401000119104", "UMLS:C0020496", "UMLS:C4072850", "UMLS:C4072851" ; oboInOwl:hasExactSynonym "Hyperossification of skull", "Hyperostosis of skull", "Sclerosis of bones of skull", "Sclerosis of skull" ; oboInOwl:hasRelatedSynonym "Increased Mineralization of skull", "Increased calcification of skull" ; oboInOwl:id "HP:0004330" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Increased skull ossification" ; rdfs:subClassOf obo:HP_0002703, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002304 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004331 obo:IAO_0000115 "A reduction in the magnitude or amount of ossification of the skull." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T11:54:00Z" ; oboInOwl:hasAlternativeId "HP:0003780" ; oboInOwl:hasDbXref "SNOMEDCT_US:253980008", "UMLS:C0432073", "UMLS:C4280533" ; oboInOwl:hasExactSynonym "Decreased bone formation of skull", "Deficient skull ossification", "Hypoossification of skull", "Ossification defect of skull", "Poorly mineralized skull", "Poorly ossified skull", "Poorly ossified skull bones" ; oboInOwl:hasRelatedSynonym "Decreased calcification of skull", "Decreased mineralization of skull" ; oboInOwl:id "HP:0004331" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Decreased skull ossification" ; rdfs:subClassOf obo:HP_0002703, obo:HP_0011849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004332 obo:IAO_0000115 "An abnormality of lymphocytes." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T06:46:00Z" ; oboInOwl:hasAlternativeId "HP:0001887", "HP:0012140" ; oboInOwl:hasDbXref "SNOMEDCT_US:250284007", "UMLS:C0427546" ; oboInOwl:hasExactSynonym "Abnormal lymphocytes", "Abnormality of cells of the lymphoid lineage" ; oboInOwl:id "HP:0004332" ; a owl:Class ; rdfs:comment "A lymphocyte refers to a cell of the B cell, T cell, or natural killer cell lineage." ; rdfs:label "Abnormal lymphocyte morphology" ; rdfs:subClassOf obo:HP_0001881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000542 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004333 obo:IAO_0000115 "The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance." ; dcterms:creator ; oboInOwl:creation_date "2008-02-28T06:48:00Z" ; oboInOwl:hasAlternativeId "HP:0001979" ; oboInOwl:hasDbXref "UMLS:C1856560" ; oboInOwl:hasExactSynonym "Bone marrow foam cells", "Large vacuolated foam cells ('NP cells') on bone marrow biopsy", "Large vacuolated foam cells on bone marrow biopsy" ; oboInOwl:id "HP:0004333" ; a owl:Class ; rdfs:label "Bone-marrow foam cells" ; rdfs:subClassOf obo:HP_0003651, obo:HP_0004311 . obo:HP_0004334 obo:IAO_0000115 "Partial or complete wasting (atrophy) of the skin." ; dcterms:creator ; oboInOwl:creation_date "2008-03-04T06:24:00Z" ; oboInOwl:hasAlternativeId "HP:0000985", "HP:0001077" ; oboInOwl:hasDbXref "MEDDRA:10040799", "SNOMEDCT_US:399979006", "SNOMEDCT_US:400190005", "UMLS:C0151514" ; oboInOwl:hasExactSynonym "Atrophic skin", "Skin atrophy", "Skin degeneration" ; oboInOwl:id "HP:0004334" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dermal atrophy" ; rdfs:subClassOf obo:HP_0008065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004336 obo:IAO_0000115 "The presence of excessive redundant myelin in the peripheral nerve sheath." ; dcterms:creator ; oboInOwl:creation_date "2008-03-04T06:41:00Z" ; oboInOwl:hasAlternativeId "HP:0003433", "HP:0006898", "HP:0007290" ; oboInOwl:hasDbXref "UMLS:C1843168" ; oboInOwl:hasExactSynonym "Excessive focal folding of myelin sheaths", "Irregular myelin foldings" ; oboInOwl:id "HP:0004336" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by nerve biopsy (e.g., sural nerve biopsy)." ; rdfs:label "Myelin outfoldings" ; rdfs:subClassOf obo:HP_0030173 . obo:HP_0004337 obo:IAO_0000115 "Abnormality of an amino acid metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T07:53:00Z" ; oboInOwl:hasDbXref "UMLS:C1328440" ; oboInOwl:hasRelatedSynonym "Amino acid levels abnormal" ; oboInOwl:id "HP:0004337" ; a owl:Class ; rdfs:label "Abnormality of amino acid metabolism" ; rdfs:subClassOf obo:HP_0032245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006520 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004338 obo:IAO_0000115 "Any deviation from the normal concentration of a aromatic amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T07:55:00Z" ; oboInOwl:hasDbXref "UMLS:C4025352" ; oboInOwl:hasExactSynonym "Abnormality of aromatic amino acid family metabolism" ; oboInOwl:id "HP:0004338" ; a owl:Class ; rdfs:label "Abnormal circulating aromatic amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004339 obo:IAO_0000115 "Any deviation from the normal concentration of a sulfur amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:01:00Z" ; oboInOwl:hasDbXref "UMLS:C4021660" ; oboInOwl:hasExactSynonym "Abnormal circulating sulphur amino acid concentration", "Abnormality of sulfur-containing amino acids" ; oboInOwl:id "HP:0004339" ; a owl:Class ; rdfs:comment "Cysteine and methionine contain a sulfur atom." ; rdfs:label "Abnormal circulating sulfur amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0000096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004340 dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:08:00Z" ; oboInOwl:hasDbXref "UMLS:C4021659" ; oboInOwl:hasExactSynonym "Abnormality of B-vitamin metabolism" ; oboInOwl:id "HP:0004340" ; a owl:Class ; rdfs:label "Abnormality of vitamin B metabolism" ; rdfs:subClassOf obo:HP_0100508 . obo:HP_0004341 dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:09:00Z" ; oboInOwl:hasDbXref "UMLS:C4021658" ; oboInOwl:hasExactSynonym "Abnormality of the vitamin B12 metabolism" ; oboInOwl:id "HP:0004341" ; a owl:Class ; rdfs:label "Abnormality of vitamin B12 metabolism" ; rdfs:subClassOf obo:HP_0004340 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004342 obo:IAO_0000115 "Abnormality of galactoside metabolism. A galactoside is a glycoside (a suger moiety bound to some other moiety) containing galactose." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4025351" ; oboInOwl:id "HP:0004342" ; a owl:Class ; rdfs:label "Abnormality of galactoside metabolism" ; rdfs:subClassOf obo:HP_0003649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0008152 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_24163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004343 obo:IAO_0000115 "An abnormality of glycosphingolipid metabolism." ; dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:35:00Z" ; oboInOwl:hasDbXref "UMLS:C4025350" ; oboInOwl:hasExactSynonym "Abnormality of glycosphingolipid metabolism" ; oboInOwl:id "HP:0004343" ; a owl:Class ; rdfs:comment "Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine. A glycosphingolipid is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid." ; rdfs:label "Abnormal glycosphingolipid metabolism" ; rdfs:subClassOf obo:HP_0010969 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004344 dcterms:creator ; oboInOwl:creation_date "2008-03-08T08:36:00Z" ; oboInOwl:hasDbXref "UMLS:C4025349" ; oboInOwl:id "HP:0004344" ; a owl:Class ; rdfs:label "Abnormality of cerebrosidase metabolism" ; rdfs:subClassOf obo:HP_0004343 . obo:HP_0004345 obo:IAO_0000115 "Defects in the lysosomal glycosidases or specific co-activators, result in accumulation of the substrates, such as glycosphingolipids, including gangliosides in GM1 gangliosidosis (Tay-Sachs disease) and GM2 gangliosidosis (Sandhoff disease)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-11T07:50:00Z" ; oboInOwl:hasDbXref "UMLS:C4025348" ; oboInOwl:id "HP:0004345" ; a owl:Class ; rdfs:comment "A ganglioside is composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain." ; rdfs:label "Ganglioside accumulation" ; rdfs:subClassOf obo:HP_0004343 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004347 obo:IAO_0000115 "Reduced function of the muscles required to generate subatmospheric pressure in the thoracic cavity during breathing: the diaphragm, the external intercostal and the interchondral part of the internal intercostal muscles." ; dcterms:creator ; oboInOwl:creation_date "2008-03-11T08:03:00Z" ; oboInOwl:hasDbXref "UMLS:C4025347" ; oboInOwl:id "HP:0004347" ; a owl:Class ; rdfs:label "Weakness of muscles of respiration" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0002795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004348 obo:IAO_0000115 "This term applies to all changes in bone mineral density which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone. Changes may affect all bones of the organism, just certain bones or only parts of bones and include decreased mineralisation as may be seen in osteoporosis or increased mineralisation and or ossification as in osteopetrosis, exostoses or any kind of atopic calicfications of different origin and distribution. The overall amount of mineralization of the bone-organ can be measured as the amount of matter per cubic centimeter of bones, usually measured by densitometry of the lumbar spine or hip. The measurements are usually reported as g/cm3 or as a Z-score (the number of standard deviations above or below the mean for the patient's age and sex). Note that measurement with this method does not reflect local changes in other bones, and as such might not be correct with regard the hole bone-organ." ; dcterms:creator ; oboInOwl:creation_date "2008-03-11T08:10:00Z" ; oboInOwl:hasDbXref "UMLS:C4021657" ; oboInOwl:hasExactSynonym "Abnormality of bone mineralisation and ossification" ; oboInOwl:id "HP:0004348" ; a owl:Class ; rdfs:label "Abnormality of bone mineral density" ; rdfs:subClassOf obo:HP_0011849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004349 obo:IAO_0000115 "A reduction of bone mineral density, that is, of the amount of matter per cubic centimeter of bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-11T08:10:00Z" ; oboInOwl:hasDbXref "UMLS:C2674432" ; oboInOwl:hasExactSynonym "Decreased bone mineral density", "Decreased bone mineral density Z score", "Low solidness and mass of the bones" ; oboInOwl:id "HP:0004349" ; a owl:Class ; rdfs:label "Reduced bone mineral density" ; rdfs:subClassOf obo:HP_0004348 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001790 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004352 obo:IAO_0000115 "Any deviation from the normal concentration of a purine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T01:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4025346" ; oboInOwl:hasExactSynonym "Abnormal circulating purine level" ; oboInOwl:id "HP:0004352" ; a owl:Class ; rdfs:comment "Purines are nitrogenous bases including the two nucleotide bases deoxyadenosine and deoxyguanosine." ; rdfs:label "Abnormal circulating purine concentration" ; rdfs:subClassOf obo:HP_0010932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006144 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004353 obo:IAO_0000115 "Any deviation from the normal concentration of a pyrimidine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T01:05:00Z" ; oboInOwl:hasDbXref "UMLS:C4025345" ; oboInOwl:id "HP:0004353" ; a owl:Class ; rdfs:label "Abnormal circulating pyrimidine concentration" ; rdfs:subClassOf obo:HP_0010932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006206 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004354 obo:IAO_0000115 "Any deviation from the normal concentration of a carboxylic acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T01:11:00Z" ; oboInOwl:hasDbXref "UMLS:C4025344" ; oboInOwl:id "HP:0004354" ; a owl:Class ; rdfs:comment "Carboxylic acid refers to an organic compound that contains a carboxyl group (-COOH)." ; rdfs:label "Abnormal circulating carboxylic acid concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004355 obo:IAO_0100001 "HP:0001939" ; oboInOwl:creation_date "2008-03-17T01:12:00Z" ; oboInOwl:id "HP:0004355" ; a owl:Class ; rdfs:label "obsolete Abnormality of proteoglycan metabolism" ; owl:deprecated true . obo:HP_0004356 dcterms:creator ; oboInOwl:creation_date "2008-03-17T02:40:00Z" ; oboInOwl:hasDbXref "UMLS:C4025342" ; oboInOwl:id "HP:0004356" ; a owl:Class ; rdfs:comment "A major lysosomal function is the breakdown and recycling of macromolecules and organelles into basic precursors." ; rdfs:label "Abnormality of lysosomal metabolism" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005764 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004357 obo:IAO_0000115 "Any deviation from the normal circulation of leucine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:02:00Z" ; oboInOwl:hasDbXref "UMLS:C4025341" ; oboInOwl:id "HP:0004357" ; a owl:Class ; rdfs:label "Abnormal circulating leucine concentration" ; rdfs:subClassOf obo:HP_0010892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006551 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004358 dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:22:00Z" ; oboInOwl:hasDbXref "UMLS:C4025340" ; oboInOwl:id "HP:0004358" ; a owl:Class ; rdfs:comment "NADPH oxidase catalyzes the production of superoxide, which in turn can react to form hydrogen peroxide, HOCl, and hydroxyl radical. Together, these oxygen-derived species participate in bacterial killing." ; rdfs:label "Abnormality of superoxide metabolism" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004359 obo:IAO_0000115 "A deviation from the normal concentration of a fatty acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:28:00Z" ; oboInOwl:hasDbXref "UMLS:C4020830", "UMLS:C4021656" ; oboInOwl:hasExactSynonym "Abnormality of fatty acid metabolism" ; oboInOwl:hasRelatedSynonym "Fatty acids abnormal" ; oboInOwl:id "HP:0004359" ; a owl:Class ; rdfs:comment "A fatty acid is an aliphatic monocarboxylic acid derived from or contained in esterified form. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. R-COOH. Fatty acids are usually derived from triglycerides or phospholipids." ; rdfs:label "Abnormal circulating fatty-acid concentration" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004360 obo:IAO_0000115 "An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:35:00Z" ; oboInOwl:hasDbXref "MSH:D000137", "UMLS:C0001118" ; oboInOwl:hasRelatedSynonym "Acid base imbalance" ; oboInOwl:id "HP:0004360" ; a owl:Class ; rdfs:label "Abnormality of acid-base homeostasis" ; rdfs:subClassOf obo:HP_0012337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_37527 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004361 obo:IAO_0000115 "An abnormal concentration of leptin in the blood." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:37:00Z" ; oboInOwl:hasDbXref "UMLS:C4025339" ; oboInOwl:hasExactSynonym "Abnormality of circulating leptin level" ; oboInOwl:id "HP:0004361" ; a owl:Class ; rdfs:label "Abnormal circulating leptin concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009758 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004362 obo:IAO_0000115 "An abnormality of the enteric nervous system, which comprises two types of ganglia, the myenteric (Auerbach's) and submucosal (Meissner's) plexuses. The enteric nervous system functions to control gut movement, fluid exchange between the gut and its lumen, and local blood flow." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T03:40:00Z" ; oboInOwl:hasAlternativeId "HP:0002596", "HP:0003283" ; oboInOwl:hasDbXref "UMLS:C4025338" ; oboInOwl:hasRelatedSynonym "Abnormality of the enteric ganglia" ; oboInOwl:id "HP:0004362" ; a owl:Class ; rdfs:label "Abnormality of enteric ganglion morphology" ; rdfs:subClassOf obo:HP_0025028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001809 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004363 obo:IAO_0000115 "Any deviation from the normal concentration of calcium in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T04:15:00Z" ; oboInOwl:hasAlternativeId "HP:0040077" ; oboInOwl:hasExactSynonym "Abnormal blood calcium concentration", "Abnormal blood calcium levels", "Abnormal circulating Ca concentration", "Abnormal circulating Ca2+ concentration" ; oboInOwl:id "HP:0004363" ; a owl:Class ; rdfs:label "Abnormal circulating calcium concentration" ; rdfs:subClassOf obo:HP_0010927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004364 obo:IAO_0000115 "Any deviation from the normal concentration of a nitrogen compound in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T04:51:00Z" ; oboInOwl:hasDbXref "UMLS:C4025336" ; oboInOwl:id "HP:0004364" ; a owl:Class ; rdfs:comment "Ammonia (NH3), one of the most clinically important nitrogen compounds in human metabolism, is a substance containing nitrogen resulting from the catabolism of protein. It is converted to the less toxic substance urea prior to excretion in urine." ; rdfs:label "Abnormal circulating nitrogen compound concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_51143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004365 obo:IAO_0000115 "Any deviation from the normal concentration of tryptophan in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T04:55:00Z" ; oboInOwl:hasDbXref "UMLS:C4025335" ; oboInOwl:hasExactSynonym "Abnormality of tryptophan metabolism" ; oboInOwl:id "HP:0004365" ; a owl:Class ; rdfs:label "Abnormal circulating tryptophan concentration" ; rdfs:subClassOf obo:HP_0004338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006568 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004366 obo:IAO_0000115 "An abnormality of glycolysis." ; dcterms:creator ; oboInOwl:creation_date "2008-03-17T05:00:00Z" ; oboInOwl:hasDbXref "UMLS:C4025334" ; oboInOwl:id "HP:0004366" ; a owl:Class ; rdfs:label "Abnormality of glycolysis" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0006096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004367 obo:IAO_0100001 "HP:0001939" ; oboInOwl:id "HP:0004367" ; a owl:Class ; rdfs:label "obsolete Abnormality of glycoprotein metabolism" ; owl:deprecated true . obo:HP_0004368 obo:IAO_0000115 "Abnormally elevated concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T06:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4025332" ; oboInOwl:hasExactSynonym "Increased purine level", "Increased purine levels" ; oboInOwl:id "HP:0004368" ; a owl:Class ; rdfs:label "Increased circulating purine concentration" ; rdfs:subClassOf obo:HP_0004352 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26401 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004369 obo:IAO_0000115 "Abnormally reduced concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T06:32:00Z" ; oboInOwl:hasDbXref "UMLS:C4025331" ; oboInOwl:hasExactSynonym "Decreased purine level", "Decreased purine levels" ; oboInOwl:id "HP:0004369" ; a owl:Class ; rdfs:label "Decreased circulating purine concentration" ; rdfs:subClassOf obo:HP_0004352 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_26401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004370 obo:IAO_0000115 "An abnormality of temperature homeostasis." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T06:34:00Z" ; oboInOwl:hasDbXref "MSH:D001832", "UMLS:C0005904", "UMLS:C1832160" ; oboInOwl:hasExactSynonym "Abnormality of temperature regulation", "Poor temperature regulation" ; oboInOwl:hasRelatedSynonym "Body temperature changes" ; oboInOwl:id "HP:0004370" ; a owl:Class ; rdfs:label "Abnormality of temperature regulation" ; rdfs:subClassOf obo:HP_0012337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001659 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004371 obo:IAO_0000115 "Abnormality of glycosaminoglycan metabolism." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T06:36:00Z" ; oboInOwl:hasDbXref "UMLS:C4025330" ; oboInOwl:id "HP:0004371" ; a owl:Class ; rdfs:comment "A glycosaminoglycan is any polysaccharide containing a substantial proportion of aminomonosaccharide residues. Glycosaminoglycan (GAG) are long unbranched polysaccharides consisting of a repeating disaccharide unit. Among the most common GAGs are chondroitin sulfate, dermatan sulfate, chondroitin sulfate, keratan sulfate, heparan sulfate, and hyaluronan." ; rdfs:label "Abnormality of glycosaminoglycan metabolism" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0030203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004372 dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:12:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:3006004", "UMLS:C0234428" ; oboInOwl:hasExactSynonym "Disturbances of consciousness", "Lowered consciousness", "Reduced consciousness/confusion" ; oboInOwl:id "HP:0004372" ; a owl:Class ; rdfs:label "Reduced consciousness/confusion" ; rdfs:subClassOf obo:HP_0011446 . obo:HP_0004373 obo:IAO_0000115 "A type of dystonia that is localized to a specific part of the body." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:33:00Z" ; oboInOwl:hasAlternativeId "HP:0007140" ; oboInOwl:hasDbXref "MSH:D020821", "SNOMEDCT_US:445006008", "UMLS:C0743332" ; oboInOwl:id "HP:0004373" ; a owl:Class ; rdfs:label "Focal dystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0004374 obo:IAO_0000115 "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a severe or complete loss of strength, whereas hemiparesis refers to a relatively mild loss of strength." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:35:00Z" ; oboInOwl:hasDbXref "UMLS:C0375206" ; oboInOwl:hasExactSynonym "Paralysis or weakness of one side of body" ; oboInOwl:id "HP:0004374" ; a owl:Class ; rdfs:label "Hemiplegia/hemiparesis" ; rdfs:subClassOf obo:HP_0010549 . obo:HP_0004375 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the nervous system." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:38:00Z" ; oboInOwl:hasDbXref "MSH:D009423", "NCIT:C3262", "SNOMEDCT_US:126950007", "UMLS:C0027766" ; oboInOwl:hasExactSynonym "Tumor of the nervous system", "Tumour of the nervous system" ; oboInOwl:hasRelatedSynonym "Neoplasia of the nervous system", "Nervous system cancer" ; oboInOwl:id "HP:0004375" ; a owl:Class ; rdfs:label "Neoplasm of the nervous system" ; rdfs:subClassOf obo:HP_0011793, obo:HP_0012639 . obo:HP_0004376 obo:IAO_0000115 "A family of tumors arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:39:00Z" ; oboInOwl:hasDbXref "UMLS:C1334953" ; oboInOwl:hasExactSynonym "Neuroblastic tumour" ; oboInOwl:id "HP:0004376" ; a owl:Class ; rdfs:comment "Along with neuroblastomas, ganglioneuromas and ganglioneuroblastomas are collectively known as neuroblastic tumors." ; rdfs:label "Neuroblastic tumor" ; rdfs:subClassOf obo:HP_0100836 . obo:HP_0004377 obo:IAO_0000115 "Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T07:44:00Z" ; oboInOwl:hasBroadSynonym "Blood tumor", "Blood tumour" ; oboInOwl:hasDbXref "MSH:D019337", "SNOMEDCT_US:129154003", "SNOMEDCT_US:269475001", "UMLS:C0376545" ; oboInOwl:hasExactSynonym "Haematological neoplasm" ; oboInOwl:id "HP:0004377" ; a owl:Class ; rdfs:label "Hematological neoplasm" ; rdfs:subClassOf obo:HP_0001871, obo:HP_0011793 . obo:HP_0004378 obo:IAO_0000115 "Abnormality of the anal canal." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:11:00Z" ; oboInOwl:hasDbXref "UMLS:C4025329" ; oboInOwl:hasExactSynonym "Abnormality of the anus" ; oboInOwl:id "HP:0004378" ; a owl:Class ; rdfs:comment "The anal canal is continuous proximally with the rectum and distally terminates with the anus." ; rdfs:label "Abnormality of the anus" ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004379 obo:IAO_0000115 "An abnormality of alkaline phosphatase level." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4020829", "UMLS:C4025328" ; oboInOwl:hasExactSynonym "Abnormality of ALP level", "Abnormality of alkaline phosphatase activity" ; oboInOwl:hasRelatedSynonym "Alkaline phosphatase abnormal" ; oboInOwl:id "HP:0004379" ; a owl:Class ; rdfs:comment "Note that the alkaline phosphatase family has four isoenzymes in humans, each of which additionally can have different isoforms. The primary clinical importance of measuring alkaline phosphatase is to check the possibility of bone disease or liver disease." ; rdfs:label "Abnormality of alkaline phosphatase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004380 obo:IAO_0000115 "Deposition of calcium salts in the aortic valve." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:52:00Z" ; oboInOwl:hasAlternativeId "HP:0004759", "HP:0005173" ; oboInOwl:hasDbXref "MSH:C562942", "SNOMEDCT_US:250978003", "UMLS:C0428791" ; oboInOwl:id "HP:0004380" ; a owl:Class ; rdfs:label "Aortic valve calcification" ; rdfs:subClassOf obo:HP_0001646, obo:HP_0005146 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004381 obo:IAO_0000115 "A pathological narrowing in the region above the aortic valve associated with restricted left ventricular outflow." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:54:00Z" ; oboInOwl:hasDbXref "Fyler:1430", "MSH:D021921", "SNOMEDCT_US:268185002", "UMLS:C0003499" ; oboInOwl:id "HP:0004381" ; a owl:Class ; rdfs:label "Supravalvular aortic stenosis" ; rdfs:subClassOf obo:HP_0031652 . obo:HP_0004382 obo:IAO_0000115 "Abnormal calcification of the mitral valve." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:55:00Z" ; oboInOwl:hasAlternativeId "HP:0005149", "HP:0200129" ; oboInOwl:hasDbXref "SNOMEDCT_US:473372009", "UMLS:C0919718" ; oboInOwl:id "HP:0004382" ; a owl:Class ; rdfs:label "Mitral valve calcification" ; rdfs:subClassOf obo:HP_0001633, obo:HP_0005146 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004383 obo:IAO_0000115 "Underdevelopment of the left side of the heart. May include atresia of the aortic or mitral orifice and hypoplasia of the ascending aorta." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:56:00Z" ; oboInOwl:hasDbXref "MSH:D018636", "SNOMEDCT_US:62067003", "UMLS:C0152101" ; oboInOwl:hasExactSynonym "Heart left ventricle hypoplasia", "Left ventricular hypoplasia", "Underdeveloped left heart" ; oboInOwl:id "HP:0004383" ; a owl:Class ; rdfs:comment "Hypoplastic left heart syndrome is an unsatisfactory term describing lethal underdevelopment of the left ventricle (LV). It represents the more severe end of a spectrum of LV hypoplasia, mandating single-ventricle palliation or cardiac transplantation. Less severe borderline ventricular hypoplasia may instead allow various biventricular therapeutic strategies and better long-term outcomes." ; rdfs:label "Hypoplastic left heart" ; rdfs:subClassOf obo:HP_0001961, obo:HP_0045017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001062 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004384 obo:IAO_0000115 "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with a short pulmonary trunk arises from the truncus arteriosus, giving rise to both pulmonary arteries." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T08:57:00Z" ; oboInOwl:hasDbXref "Fyler:0510", "Fyler:510", "UMLS:C1834934" ; oboInOwl:hasExactSynonym "Persistent truncus arteriosus type I", "Type 1 truncus arteriosus" ; oboInOwl:id "HP:0004384" ; a owl:Class ; rdfs:comment "According to the Van Praagh classification (PMID:2856609). The Van Praagh classification additionally specifies the presence (subtype A) or absence (subtype B) of a ventricular septal defect." ; rdfs:label "Type I truncus arteriosus" ; rdfs:subClassOf obo:HP_0001660 . obo:HP_0004385 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:00:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:236077008", "UMLS:C0473133" ; oboInOwl:hasExactSynonym "Protracted diarrhoea" ; oboInOwl:id "HP:0004385" ; a owl:Class ; rdfs:label "Protracted diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0004386 obo:IAO_0000115 "Inflammation of the alimentary part of the gastrointestinal system." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:01:00Z" ; oboInOwl:hasDbXref "UMLS:C1535950" ; oboInOwl:hasExactSynonym "GI inflammation", "Gastrointestinal inflammation" ; oboInOwl:id "HP:0004386" ; a owl:Class ; rdfs:label "Gastrointestinal inflammation" ; rdfs:subClassOf obo:HP_0012649, obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004387 obo:IAO_0000115 "An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:02:00Z" ; oboInOwl:hasDbXref "MSH:D004760", "SNOMEDCT_US:43752006", "UMLS:C0014356" ; oboInOwl:id "HP:0004387" ; a owl:Class ; rdfs:label "Enterocolitis" ; rdfs:subClassOf obo:HP_0002583 . obo:HP_0004388 obo:IAO_0000115 "A colon of abnormally small caliber." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:02:00Z" ; oboInOwl:hasDbXref "MSH:C562563", "SNOMEDCT_US:18389004", "UMLS:C0266200", "UMLS:C3553395" ; oboInOwl:hasRelatedSynonym "Microcolon on contrast enema" ; oboInOwl:id "HP:0004388" ; a owl:Class ; rdfs:label "Microcolon" ; rdfs:subClassOf obo:HP_0100811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004389 obo:IAO_0000115 "A functional rather than mechanical obstruction of the intestines, associated with manifestations that resemble those caused by an intestinal obstruction, including distension, abdominal pain, nausea, vomiting, constipation or diarrhea, in an individual in whom a mechanical blockage has been excluded." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:03:00Z" ; oboInOwl:hasDbXref "MSH:D007418", "SNOMEDCT_US:235825006", "SNOMEDCT_US:715201005", "UMLS:C0021847" ; oboInOwl:hasExactSynonym "Intestinal pseudoobstruction" ; oboInOwl:id "HP:0004389" ; a owl:Class ; rdfs:label "Intestinal pseudo-obstruction" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0002579 . obo:HP_0004390 obo:IAO_0000115 "Polyp-like protrusions which are histologically hamartomas. These can occur throughout the gastrointestinal tract. Hamartomatous polyps are composed of the normal cellular elements of the gastrointestinal tract, but have a markedly distorted architecture." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:04:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:27391005", "UMLS:C0334092", "UMLS:C3277418" ; oboInOwl:hasExactSynonym "Gastrointestinal hamartoma", "Hamartomatous polyps" ; oboInOwl:hasRelatedSynonym "Gastrointestinal hamartomatous polyps" ; oboInOwl:id "HP:0004390" ; a owl:Class ; rdfs:comment "Patients with Cowden-Syndrom for example often have multiple hamartomatous gastrointestinal polyps." ; rdfs:label "Hamartomatous polyposis" ; rdfs:subClassOf obo:HP_0005266, obo:HP_0010566 . obo:HP_0004392 obo:IAO_0000115 "A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:08:00Z" ; oboInOwl:hasDbXref "MSH:D011535", "SNOMEDCT_US:5187006", "UMLS:C0033770" ; oboInOwl:hasExactSynonym "Prune belly" ; oboInOwl:id "HP:0004392" ; a owl:Class ; rdfs:comment "Wrinkly folds of skin covering the abdomen as a result of partial or complete lack of abdominal muscles." ; rdfs:label "Prune belly" ; rdfs:subClassOf obo:HP_0004298 . obo:HP_0004394 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:11:00Z" ; oboInOwl:hasDbXref "MSH:C562464", "SNOMEDCT_US:78809005", "SNOMEDCT_US:87252009", "UMLS:C0236048" ; oboInOwl:id "HP:0004394" ; a owl:Class ; rdfs:label "Multiple gastric polyps" ; rdfs:subClassOf obo:HP_0006753 . obo:HP_0004395 obo:IAO_0000115 "A deficiency in the intake of energy and nutrients." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:12:00Z" ; oboInOwl:hasDbXref "MSH:D044342", "SNOMEDCT_US:248325000", "SNOMEDCT_US:2492009", "SNOMEDCT_US:47563007", "SNOMEDCT_US:65404009", "SNOMEDCT_US:70241007", "UMLS:C0162429" ; oboInOwl:hasExactSynonym "Malnutrition" ; oboInOwl:id "HP:0004395" ; a owl:Class ; rdfs:label "Malnutrition" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0004396 obo:IAO_0000115 "A reduced desire to eat." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:12:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:64379006", "UMLS:C0232462" ; oboInOwl:hasExactSynonym "Decreased appetite", "Loss of appetite", "Poor appetite" ; oboInOwl:hasRelatedSynonym "No appetite" ; oboInOwl:id "HP:0004396" ; a owl:Class ; rdfs:label "Poor appetite" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0004397 obo:IAO_0000115 "Abnormal displacement or malposition of the anus." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:13:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:5153001", "UMLS:C0266231" ; oboInOwl:hasExactSynonym "Abnormal anus position", "Anus malposition" ; oboInOwl:id "HP:0004397" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ectopic anus" ; rdfs:subClassOf obo:HP_0034915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004398 obo:IAO_0000115 "The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the oesophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:14:00Z" ; oboInOwl:hasDbXref "MSH:D010437", "SNOMEDCT_US:13200003", "UMLS:C0030920" ; oboInOwl:hasExactSynonym "Sore in the lining of gastrointestinal tract" ; oboInOwl:id "HP:0004398" ; a owl:Class ; rdfs:comment "Symptoms of peptic ulcer disease have limited predictive value because they are non-specific. Patients with duodenal ulcers typically feel hungry or have nocturnal abdominal pain. By contrast, patients with gastric ulcers have postprandial abdominal pain, nausea, vomiting, and weight loss. Patients with untreated peptic ulcer disease typically have relapsing symptoms because of spontaneous healing and relapse while the causal factor (eg, H pylori infection or NSAID use) persists." ; rdfs:label "Peptic ulcer" ; rdfs:subClassOf obo:HP_0034274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_579 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004399 obo:IAO_0000115 "Congenital atresia of the pylorus." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:15:00Z" ; oboInOwl:hasDbXref "UMLS:C4025327" ; oboInOwl:id "HP:0004399" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Congenital pyloric atresia" ; rdfs:subClassOf obo:HP_0004400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001166 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004400 obo:IAO_0000115 "An abnormality of the pylorus." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:15:00Z" ; oboInOwl:hasDbXref "UMLS:C4025326" ; oboInOwl:id "HP:0004400" ; a owl:Class ; rdfs:label "Abnormality of the pylorus" ; rdfs:subClassOf obo:HP_0002577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001166 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004401 obo:IAO_0000115 "Obstruction of the intestine due to abnormally thick meconium." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:16:00Z" ; oboInOwl:hasAlternativeId "HP:0002610", "HP:0004402" ; oboInOwl:hasDbXref "SNOMEDCT_US:206523001", "SNOMEDCT_US:233662009", "SNOMEDCT_US:86092005", "UMLS:C0398349", "UMLS:C2939175", "UMLS:C3553397" ; oboInOwl:hasExactSynonym "Meconium ileus in neonates" ; oboInOwl:hasRelatedSynonym "Distal intestinal obstruction syndrome", "Meconium ileus on ultrasonography" ; oboInOwl:id "HP:0004401" ; a owl:Class ; rdfs:comment "Obstruction of the intestine is known as ileus." ; rdfs:label "Meconium ileus" ; rdfs:subClassOf obo:HP_0010676 . obo:HP_0004403 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:17:00Z" ; oboInOwl:hasDbXref "UMLS:C4025325" ; oboInOwl:id "HP:0004403" ; a owl:Class ; rdfs:label "Proximal esophageal atresia" ; rdfs:subClassOf obo:HP_0002032 . obo:HP_0004404 obo:IAO_0000115 "An abnormality of the nipple." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:18:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:700153004", "UMLS:C3839073" ; oboInOwl:hasExactSynonym "Abnormality of the nipple" ; oboInOwl:id "HP:0004404" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal nipple morphology" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004405 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:19:00Z" ; oboInOwl:hasDbXref "UMLS:C1855513" ; oboInOwl:hasExactSynonym "Prominent nipples" ; oboInOwl:id "HP:0004405" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent nipples" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004406 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:20:00Z" ; oboInOwl:hasAlternativeId "HP:0003684" ; oboInOwl:hasDbXref "UMLS:C3809715" ; oboInOwl:hasExactSynonym "Recurrent epistaxes", "Recurrent epistaxis", "Recurring nosebleed", "Spontaneous, recurrent nosebleed" ; oboInOwl:id "HP:0004406" ; a owl:Class ; rdfs:label "Spontaneous, recurrent epistaxis" ; rdfs:subClassOf obo:HP_0000421 . obo:HP_0004407 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:20:00Z" ; oboInOwl:hasDbXref "UMLS:C1857499" ; oboInOwl:id "HP:0004407" ; a owl:Class ; rdfs:label "Bony paranasal bossing" ; rdfs:subClassOf obo:HP_0012812 . obo:HP_0004408 obo:IAO_0000115 "An anomaly in the ability to perceive and distinguish scents (odors)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:21:00Z" ; oboInOwl:hasAlternativeId "HP:0004410" ; oboInOwl:hasDbXref "UMLS:C4021655" ; oboInOwl:hasExactSynonym "Abnormal sense of smell", "Abnormality of olfaction", "Abnormality of the sense of smell", "Smell defect" ; oboInOwl:id "HP:0004408" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the sense of smell" ; rdfs:subClassOf obo:HP_0000366, obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007608 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004409 obo:IAO_0000115 "A decreased sensitivity to odorants (that is, a decreased ability to perceive odors)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:21:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:83156004", "UMLS:C2364082" ; oboInOwl:hasExactSynonym "Decreased smell sensation", "Sense of smell impaired" ; oboInOwl:id "HP:0004409" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hyposmia" ; rdfs:subClassOf obo:HP_0004408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001552 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007608 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004411 obo:IAO_0000115 "Positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:23:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:126660000", "UMLS:C0549397" ; oboInOwl:hasExactSynonym "Crooked nasal septum", "Crooked septum of nose", "Deviated nasal septum", "Deviated septum of nose" ; oboInOwl:id "HP:0004411" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Deviated nasal septum" ; rdfs:subClassOf obo:HP_0000419 . obo:HP_0004414 obo:IAO_0000115 "An abnormality of the pulmonary artery." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:28:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:128588008", "SNOMEDCT_US:198914002", "SNOMEDCT_US:36110001", "UMLS:C0009681" ; oboInOwl:hasExactSynonym "Abnormality of lung artery" ; oboInOwl:id "HP:0004414" ; a owl:Class ; rdfs:label "Abnormality of the pulmonary artery" ; rdfs:subClassOf obo:HP_0004930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004415 obo:IAO_0000115 "An abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:28:00Z" ; oboInOwl:hasDbXref "Fyler:1622", "MSH:D000071079", "SNOMEDCT_US:95441000", "UMLS:C0238397" ; oboInOwl:hasExactSynonym "Narrowing of lung artery" ; oboInOwl:id "HP:0004415" ; a owl:Class ; rdfs:comment "Stenosis, or narrowing, of the branches of the pulmonary artery is a type of congenital heart disease that, if left untreated, may lead to significant complications. Ideally, interventions to treat stenosis occur before significant complications or long-term sequelae take place, often within the first 2 years of life." ; rdfs:label "Pulmonary artery stenosis" ; rdfs:subClassOf obo:HP_0030966 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004416 dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:28:00Z" ; oboInOwl:hasBroadSynonym "Premature plaque build-up in arteries" ; oboInOwl:hasDbXref "UMLS:C4021654", "UMLS:C4280264" ; oboInOwl:hasExactSynonym "Premature atherosclerosis" ; oboInOwl:id "HP:0004416" ; a owl:Class ; rdfs:label "Precocious atherosclerosis" ; rdfs:subClassOf obo:HP_0002621 . obo:HP_0004417 obo:IAO_0000115 "Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:29:00Z" ; oboInOwl:hasDbXref "MSH:D007383", "SNOMEDCT_US:63491006", "UMLS:C0021775" ; oboInOwl:id "HP:0004417" ; a owl:Class ; rdfs:comment "Vascular intermittent claudication caused by peripheral arterial disease most often related to severe atherosclerosis." ; rdfs:label "Intermittent claudication" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0004418 obo:IAO_0000115 "Inflammation of a vein associated with venous thrombosis (blood clot formation within the vein)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:30:00Z" ; oboInOwl:hasDbXref "MSH:D013924", "SNOMEDCT_US:64156001", "UMLS:C0040046" ; oboInOwl:id "HP:0004418" ; a owl:Class ; rdfs:label "Thrombophlebitis" ; rdfs:subClassOf obo:HP_0004936 . obo:HP_0004419 obo:IAO_0000115 "Repeated episodes of inflammation of a vein associated with venous thrombosis (blood clot formation within the vein)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:31:00Z" ; oboInOwl:hasDbXref "UMLS:C3550150" ; oboInOwl:hasExactSynonym "Recurrent phlebitis", "Recurrent thrombosis" ; oboInOwl:id "HP:0004419" ; a owl:Class ; rdfs:label "Recurrent thrombophlebitis" ; rdfs:subClassOf obo:HP_0004418 . obo:HP_0004420 obo:IAO_0000115 "The formation of a blood clot inside an artery." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:32:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:65198009", "UMLS:C0151942" ; oboInOwl:hasExactSynonym "Blood clot in artery" ; oboInOwl:id "HP:0004420" ; a owl:Class ; rdfs:label "Arterial thrombosis" ; rdfs:subClassOf obo:HP_0001977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004421 obo:IAO_0000115 "Abnormal increase in systolic blood pressure." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:33:00Z" ; oboInOwl:hasAlternativeId "HP:0004956" ; oboInOwl:hasDbXref "UMLS:C1840374" ; oboInOwl:hasExactSynonym "Elevated systolic BP" ; oboInOwl:id "HP:0004421" ; a owl:Class ; rdfs:comment "Normal systolic blood pressure is less than 120 mmHg in adults." ; rdfs:label "Elevated systolic blood pressure" ; rdfs:subClassOf obo:HP_0032263 . obo:HP_0004422 obo:IAO_0000115 "A narrowing of the biparietal diameter (i.e., of the transverse distance between the protuberances of the two parietal bones of the skull)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:35:00Z" ; oboInOwl:hasDbXref "UMLS:C1854418", "UMLS:C4280532" ; oboInOwl:hasRelatedSynonym "Decreased width of the skull" ; oboInOwl:id "HP:0004422" ; a owl:Class ; rdfs:label "Biparietal narrowing" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0004423 obo:IAO_0000115 "Cranium bifidum occultum, also known as Catlin mark, is a congenital midline skull defect presenting as an enlarged posterior fontanelle in the upper posterior angle of the parietal bone close to the intersection of the sagittal and lambdoid sutures.1, 2, 3 Cranium bifidum occultum occurs due to a defect in intramembranous ossification, a process through which skull bones (frontal, parietal, squamous temporal and occipital bones superior to the mendosal suture) ossify under a vascularized membrane toward the midline to cover the brain.1, 4, 5 Unlike cranium bifidum cysticum, cranium bifidum occultum does not have herniation of intracranial contents. As the skull grows, the midline cranium bifidum occultum defect is separated into bilateral enlarged parietal foramina (EPF) by a midline osseous bridge." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:37:00Z" ; oboInOwl:hasDbXref "MSH:C566826", "SNOMEDCT_US:718099006", "UMLS:C1868598" ; oboInOwl:id "HP:0004423" ; a owl:Class ; rdfs:comment "Cranium bifidum tends to resolve into distinct enlarged parietal foramina over the first few years of life through the midline ossification of a central bridge of bone bisecting the defect." ; rdfs:label "Cranium bifidum occultum" ; rdfs:subClassOf obo:HP_0002084 . obo:HP_0004425 obo:IAO_0000115 "A forehead with abnormal flatness." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:41:00Z" ; oboInOwl:hasAlternativeId "HP:0004659" ; oboInOwl:hasDbXref "UMLS:C1857485" ; oboInOwl:hasExactSynonym "Flat forehead", "Flattened forehead", "Frontal flattening" ; oboInOwl:id "HP:0004425" ; a owl:Class ; rdfs:label "Flat forehead" ; rdfs:subClassOf obo:HP_0000290 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004426 obo:IAO_0000115 "An abnormality of the cheek- one of two bilateral soft tissue facial structures in the region of the face inferior to the eyes and between the nose and the ear. \"Buccal\" means relating to the cheek. The cheek is part of the midface" ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:42:00Z" ; oboInOwl:hasDbXref "UMLS:C4025324" ; oboInOwl:hasExactSynonym "Abnormality of the cheek", "Abnormality of the cheeks" ; oboInOwl:hasNarrowSynonym "Anomaly of the cheeks", "Deformity of the cheeks", "Malformation of the cheeks" ; oboInOwl:id "HP:0004426" ; a owl:Class ; rdfs:label "Abnormal cheek morphology" ; rdfs:subClassOf obo:HP_0000309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004428 obo:IAO_0000115 "This is a description previously used to describe a facial form characterized by a short, upturned nose, wide mouth, widely spaced eyes, and full cheeks. Because of the imprecision in this definition it is preferable to describe these features precisely. This term is retained because it was often used in the past, but it should not be used for new annotations." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:43:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:69288002", "UMLS:C0332606" ; oboInOwl:hasExactSynonym "Elf-like facial appearance", "Elf-like facial features" ; oboInOwl:hasRelatedSynonym "Leprechaun facies" ; oboInOwl:id "HP:0004428" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Elfin facies" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0004429 obo:IAO_0000115 "Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:45:00Z" ; oboInOwl:hasAlternativeId "HP:0005364" ; oboInOwl:hasDbXref "UMLS:C1837066" ; oboInOwl:id "HP:0004429" ; a owl:Class ; rdfs:label "Recurrent viral infections" ; rdfs:subClassOf obo:HP_0002719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001669 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0051607 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004430 obo:IAO_0000115 "A type of primary immune deficiency that is characterized by a more severe defect in both the T- and B-lymphocyte systems." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:46:00Z" ; oboInOwl:hasDbXref "MSH:D016511", "SNOMEDCT_US:31323000", "UMLS:C0085110" ; oboInOwl:hasExactSynonym "Immunodeficiency, severe combined" ; oboInOwl:id "HP:0004430" ; a owl:Class ; rdfs:label "Severe combined immunodeficiency" ; rdfs:subClassOf obo:HP_0005387 . obo:HP_0004431 obo:IAO_0000115 "An immunodeficiency defined by the absent or suboptimal functioning of one of the complement system proteins." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:51:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:24743004", "UMLS:C0272242" ; oboInOwl:id "HP:0004431" ; a owl:Class ; rdfs:label "Complement deficiency" ; rdfs:subClassOf obo:HP_0005339 . obo:HP_0004432 obo:IAO_0000115 "A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:47:00Z" ; oboInOwl:hasAlternativeId "HP:0008328" ; oboInOwl:hasDbXref "MSH:D000361", "SNOMEDCT_US:119249001", "UMLS:C0001768" ; oboInOwl:hasExactSynonym "Agammaglobulinaemia" ; oboInOwl:id "HP:0004432" ; a owl:Class ; rdfs:label "Agammaglobulinemia" ; rdfs:subClassOf obo:HP_0004313 . obo:HP_0004433 obo:IAO_0000115 "Deficiency of secretory IgA (polymers of 2-4 IgA monomers are linked by two additional chains) and is the primary antibody response at the mucosal level, where it forms immune complexes with pathogens and allergens." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:48:00Z" ; oboInOwl:hasDbXref "MSH:C562869", "SNOMEDCT_US:234554004", "UMLS:C0398709" ; oboInOwl:id "HP:0004433" ; a owl:Class ; rdfs:label "Secretory IgA deficiency" ; rdfs:subClassOf obo:HP_0041078 . obo:HP_0004434 obo:IAO_0000115 "Concentration of the complement component C8 in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:53:00Z" ; oboInOwl:hasDbXref "UMLS:C3151082" ; oboInOwl:hasExactSynonym "C8 deficiency", "Decreased serum complement C8" ; oboInOwl:id "HP:0004434" ; a owl:Class ; rdfs:comment "The eighth component of complement (C8) plays an important role in the function of membrane attack complex (MAC) that is generated on target cells upon activation of the complement system. MAC is generated by sequential addition of C5b, C6, C7, C8, and C9 molecules, which results in the transmembrane pore and eventual cell lysis. Individuals with C8 deficiency tend to have recurrent neisserial infections." ; rdfs:label "Decreased circulating complement C8 concentration" ; rdfs:subClassOf obo:HP_0033057 . obo:HP_0004437 obo:IAO_0000115 "Excessive growth of the bones of cranium, i.e., of the skull." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:57:00Z" ; oboInOwl:hasAlternativeId "HP:0002698" ; oboInOwl:hasBroadSynonym "Enlargement of skull bones", "Excessive growth of skull bones", "Hypertrophy of cranial bones", "Overgrowth of skull bones", "Thick skull bones" ; oboInOwl:hasDbXref "UMLS:C1832451", "UMLS:C4280528", "UMLS:C4280529", "UMLS:C4280530", "UMLS:C4280531" ; oboInOwl:hasExactSynonym "Hyperostosis of cranial bones", "Hyperostosis of cranial vault", "Increased ossification of cranial bones" ; oboInOwl:id "HP:0004437" ; a owl:Class ; rdfs:label "Cranial hyperostosis" ; rdfs:subClassOf obo:HP_0002683, obo:HP_0100774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004438 obo:IAO_0000115 "Bony overgrowth of the internal (endosteal) surface of the frontal bone." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:57:00Z" ; oboInOwl:hasBroadSynonym "Enlargement of the inner surface of the frontal bone", "Hypertrophy of the internal surface of the frontal bone", "Increased ossification of the internal surface of the frontal bone", "Overgrowth of the inside of the frontal bone", "Thick inner surface of the frontal bone", "Thick internal surface of the frontal bone" ; oboInOwl:hasDbXref "MSH:D006957", "SNOMEDCT_US:82054006", "UMLS:C0020494", "UMLS:C4280524", "UMLS:C4280525", "UMLS:C4280526", "UMLS:C4280527" ; oboInOwl:hasExactSynonym "Excessive growth of inner surface of the frontal bone", "Hyperostosis of the internal surface of the frontal bone", "Overgrowth of the inner surface of the frontal bone" ; oboInOwl:id "HP:0004438" ; a owl:Class ; rdfs:label "Hyperostosis frontalis interna" ; rdfs:subClassOf obo:HP_0004437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004439 obo:IAO_0000115 "A characteristic appearance resulting from defective ossification of craniofacial bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:58:00Z" ; oboInOwl:hasDbXref "MSH:D003394", "SNOMEDCT_US:28861008", "UMLS:C0010273" ; oboInOwl:hasExactSynonym "Crouzon syndrome" ; oboInOwl:id "HP:0004439" ; a owl:Class ; rdfs:comment "Note: This term is used in the medical literature to describe an appearance of the face of patients with Crouzon syndrome (also called craniofacial dysostosis), which is characterized by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla. This is thus probably mainly used as a bundled term and should be replaced by better descriptions in the future." ; rdfs:label "Craniofacial dysostosis" ; rdfs:subClassOf obo:HP_0000271, obo:HP_0000929 . obo:HP_0004440 obo:IAO_0000115 "Premature closure of the coronal suture of skull." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T09:59:00Z" ; oboInOwl:hasAlternativeId "HP:0002675", "HP:0002685", "HP:0002739", "HP:0004441" ; oboInOwl:hasDbXref "UMLS:C1856266" ; oboInOwl:hasExactSynonym "Coronal suture craniosynostosis", "Coronal suture synostosis", "Craniosynostosis of coronal suture" ; oboInOwl:id "HP:0004440" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Coronal craniosynostosis" ; rdfs:subClassOf obo:HP_0001363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004442 obo:IAO_0000115 "A kind of craniosynostosis affecting the sagittal suture." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:01:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:109418001", "UMLS:C0432123" ; oboInOwl:hasExactSynonym "Craniosynostosis, sagittal", "Craniosynostosis, sagittal suture", "Early closure of midline skull joint", "Midline skull joint closes early", "Sagittal suture synostosis" ; oboInOwl:id "HP:0004442" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sagittal craniosynostosis" ; rdfs:subClassOf obo:HP_0001363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002492 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004443 obo:IAO_0000115 "A kind of craniosynostosis affecting the lambdoidal suture." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:01:00Z" ; oboInOwl:hasAlternativeId "HP:0004486" ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:109417006", "UMLS:C1833340" ; oboInOwl:hasExactSynonym "Lambdoid suture craniosynostosis", "Lambdoid suture synostosis" ; oboInOwl:id "HP:0004443" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lambdoidal craniosynostosis" ; rdfs:subClassOf obo:HP_0001363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002491 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004444 obo:IAO_0000115 "The presence of erythrocytes that are sphere-shaped." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:05:00Z" ; oboInOwl:hasAlternativeId "HP:0004816" ; oboInOwl:hasDbXref "SNOMEDCT_US:17235000", "UMLS:C0553720" ; oboInOwl:id "HP:0004444" ; a owl:Class ; rdfs:comment "Erythrocytes are normally biconcave rather than spherical." ; rdfs:label "Spherocytosis" ; rdfs:subClassOf obo:HP_0004447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001499 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004445 obo:IAO_0000115 "The presence of elliptical, cigar-shaped erythrocytes on peripheral blood smear." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:05:00Z" ; oboInOwl:hasAlternativeId "HP:0004837" ; oboInOwl:hasDbXref "MSH:D004612", "SNOMEDCT_US:178935009", "SNOMEDCT_US:191169008", "SNOMEDCT_US:250242004", "UMLS:C0013902", "UMLS:C0427480" ; oboInOwl:hasExactSynonym "Ovalocytes", "Ovalocytosis" ; oboInOwl:hasRelatedSynonym "Elliptocyte", "Hereditary elliptocytosis" ; oboInOwl:id "HP:0004445" ; a owl:Class ; rdfs:comment "Elliptocytes (ovalocytes) are abnormal erythrocytes ranging from slightly oval to elongated cigar-shaped forms." ; rdfs:label "Elliptocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0004446 obo:IAO_0000115 "The presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:05:00Z" ; oboInOwl:hasAlternativeId "HP:0004801" ; oboInOwl:hasDbXref "UMLS:C0677598" ; oboInOwl:hasExactSynonym "Red cell stomatocytosis", "erythrocyte stomatocytes" ; oboInOwl:id "HP:0004446" ; a owl:Class ; rdfs:label "Stomatocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0004447 obo:IAO_0000115 "The presence of abnormally shaped erythrocytes." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:06:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165479004", "UMLS:C0221281" ; oboInOwl:id "HP:0004447" ; a owl:Class ; rdfs:comment "General description for abnormally shaped erythrocytes." ; rdfs:label "Poikilocytosis" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004448 obo:IAO_0000115 "Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as fulminant if there is onset of encephalopathy within 4 weeks of the onset of symptoms in a patient with a previously healthy liver." ; dcterms:creator ; oboInOwl:creation_date "2008-03-18T10:09:00Z" ; oboInOwl:hasDbXref "MSH:D017114", "SNOMEDCT_US:197270009", "SNOMEDCT_US:235884008", "UMLS:C0162557" ; oboInOwl:id "HP:0004448" ; a owl:Class ; rdfs:label "Fulminant hepatic failure" ; rdfs:subClassOf obo:HP_0006554 . obo:HP_0004450 obo:IAO_0000115 "A groove of the skin immediately in front of the ear." ; oboInOwl:hasDbXref "UMLS:C1852411" ; oboInOwl:hasExactSynonym "Preauricular skin furrows", "Preauricular skin groove", "Preauricular skin sulcus", "Skin groove in front of the ear", "Skin sulcus in front of the ear" ; oboInOwl:id "HP:0004450" ; a owl:Class ; rdfs:label "Preauricular skin furrow" ; rdfs:subClassOf obo:HP_0000383 . obo:HP_0004451 obo:IAO_0000115 "A rudimentary tag of ear tissue often containing a core of cartilage and located just in back of the auricle (outer part of the ear)." ; oboInOwl:hasDbXref "UMLS:C4025323" ; oboInOwl:hasExactSynonym "Postauricular acrochordon", "Postauricular fibroepithelial polyp", "Skin tag behind the ear" ; oboInOwl:id "HP:0004451" ; a owl:Class ; rdfs:label "Postauricular skin tag" ; rdfs:subClassOf obo:HP_0000383 . obo:HP_0004452 obo:IAO_0000115 "An abnormality of the middle-ear ossicles (three small bones called malleus, incus, and stapes) that are contained within the middle ear and serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea)." ; oboInOwl:hasAlternativeId "HP:0001759" ; oboInOwl:hasDbXref "UMLS:C1836678" ; oboInOwl:hasExactSynonym "Malformed ossicles", "Ossicular malformation" ; oboInOwl:id "HP:0004452" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the middle ear ossicles" ; rdfs:subClassOf obo:HP_0008609 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001686 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004453 obo:IAO_0000115 "A condition in which the superior portion of the helix is folded over to a greater degree than normal." ; oboInOwl:hasDbXref "UMLS:C1865304" ; oboInOwl:hasExactSynonym "Overfolding of superior helix" ; oboInOwl:id "HP:0004453" ; a owl:Class ; rdfs:label "Overfolding of the superior helices" ; rdfs:subClassOf obo:HP_0000396 . obo:HP_0004454 oboInOwl:hasDbXref "UMLS:C1970887" ; oboInOwl:id "HP:0004454" ; a owl:Class ; rdfs:label "Abnormal middle ear reflexes" ; rdfs:subClassOf obo:HP_0011452 . obo:HP_0004458 obo:IAO_0000115 "The presence of a dilated inner part of external acoustic meatus." ; oboInOwl:hasDbXref "UMLS:C2676973" ; oboInOwl:hasExactSynonym "Bulbous internal auditory canal", "Enlarged internal auditory canal" ; oboInOwl:id "HP:0004458" ; a owl:Class ; rdfs:label "Dilatated internal auditory canal" ; rdfs:subClassOf obo:HP_0011384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011859 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004459 obo:IAO_0000115 "A benign bony growth projecting outward from a bone surface within the external auditory canal." ; oboInOwl:hasDbXref "SNOMEDCT_US:19560007", "UMLS:C0155411" ; oboInOwl:hasExactSynonym "External auditory canal exostoses" ; oboInOwl:id "HP:0004459" ; a owl:Class ; rdfs:label "Exostosis of the external auditory canal" ; rdfs:subClassOf obo:HP_0000372, obo:HP_0040095, obo:HP_0100777 . obo:HP_0004461 obo:IAO_0000115 "Pits in the earlobes at the location where ears are typically pierced for earrings." ; oboInOwl:hasDbXref "UMLS:C1969394" ; oboInOwl:id "HP:0004461" ; a owl:Class ; rdfs:label "Congenital earlobe sinuses" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0004463 obo:IAO_0000115 "Lack of measurable response to stimulation of auditory evoked potentials." ; oboInOwl:hasDbXref "UMLS:C1836742" ; oboInOwl:hasExactSynonym "No auditory brainstem response" ; oboInOwl:id "HP:0004463" ; a owl:Class ; rdfs:label "Absent brainstem auditory responses" ; rdfs:subClassOf obo:HP_0006958 . obo:HP_0004464 obo:IAO_0000115 "Benign congenital lesion of the postauricular soft tissue consisting of a blind-ending narrow tube or pit." ; oboInOwl:hasDbXref "SNOMEDCT_US:43887004", "UMLS:C0395905" ; oboInOwl:hasExactSynonym "Pit behind the ear", "Postauricular earpits", "Postauricular fistula", "Posterior auricular pit", "Posterior auricular sinus" ; oboInOwl:id "HP:0004464" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Postauricular pit" ; rdfs:subClassOf obo:HP_0100277 . obo:HP_0004466 oboInOwl:hasDbXref "UMLS:C4025322" ; oboInOwl:id "HP:0004466" ; a owl:Class ; rdfs:label "Prolonged brainstem auditory evoked potentials" ; rdfs:subClassOf obo:HP_0006958 . obo:HP_0004467 obo:IAO_0000115 "Small indentation anterior to the insertion of the ear." ; oboInOwl:hasAlternativeId "HP:0000392", "HP:0004460", "HP:0005118", "HP:0008552", "HP:0008578" ; oboInOwl:hasDbXref "MSH:C563015", "SNOMEDCT_US:1955003", "SNOMEDCT_US:204271000", "SNOMEDCT_US:204272007", "UMLS:C0266610", "UMLS:C0266625", "UMLS:C0546969" ; oboInOwl:hasExactSynonym "Ear pit", "Pit in front of the ear", "Preauricular earpits", "Preauricular fistulas", "Preauricular pits", "Preauricular sinus" ; oboInOwl:id "HP:0004467" ; a owl:Class ; rdfs:comment "Preauricular cysts and sinuses are ectodermal remnants from an aberrant development of the auditory tubercles, tend to be bilateral and are localized anterior to the tragus of the ear. The preauricular sinus is a benign congenital lesion of the preauricular soft tissue consisting of a blind-ending narrow tube or pit. It is also known as preauricular pit, preauricular fistula, preauricular tract and preauricular cyst. It can be asymptomatic or present as an infected and discharging sinus. It presents as a small pit adjacent to the external ear usually located at the anterior margin of the ascending limb of the helix. The preauricular sinus is variably also termed a preauricular pit, preauricular fistula, preauricular tract and preauricular cyst." ; rdfs:label "Preauricular pit" ; rdfs:subClassOf obo:HP_0100277 . obo:HP_0004468 obo:IAO_0000115 "An abnormality of the C-shaped rings of hyaline cartilage, normally 16 to 20 in number, that occupy the anterior two-thirds of the circumference of the trachea (the posterior portion of the ring is completed by fibrous and smooth muscle tissue)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1863406" ; oboInOwl:hasExactSynonym "Abnormal tracheal cartilaginous ring" ; oboInOwl:id "HP:0004468" ; a owl:Class ; rdfs:label "Anomalous tracheal cartilage" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0004469 obo:IAO_0000115 "Chronic inflammation of the bronchi." ; oboInOwl:hasDbXref "MSH:D029481", "SNOMEDCT_US:63480004", "UMLS:C0008677" ; oboInOwl:id "HP:0004469" ; a owl:Class ; rdfs:label "Chronic bronchitis" ; rdfs:subClassOf obo:HP_0012387 . obo:HP_0004470 obo:IAO_0000115 "A congenital defect in the occipital region of the skull, covered by skin of the scalp and containing meninges or remnants of glial or neural tissues." ; oboInOwl:hasDbXref "UMLS:C1836600" ; oboInOwl:id "HP:0004470" ; a owl:Class ; rdfs:label "Atretic occipital cephalocele" ; rdfs:subClassOf obo:HP_0011815 . obo:HP_0004471 obo:IAO_0000115 "A developmental defect resulting in the congenital absence of skin on the scalp vertex, often just lateral to the midline." ; oboInOwl:hasDbXref "UMLS:C1970112" ; oboInOwl:hasExactSynonym "Absent cutis congenita of vertex", "Aplasia cutis congenita of vertex" ; oboInOwl:id "HP:0004471" ; a owl:Class ; rdfs:label "Aplasia cutis congenita over the scalp vertex" ; rdfs:subClassOf obo:HP_0007385 . obo:HP_0004472 obo:IAO_0000115 "Hyperostosis (bony overgrowth) of the mandible." ; oboInOwl:hasBroadSynonym "Excessive growth of mandibular bone", "Overgrowth of mandibular bone", "Thick lower jaw bone", "Thick mandibular bone" ; oboInOwl:hasDbXref "UMLS:C4025321", "UMLS:C4280521", "UMLS:C4280522", "UMLS:C4280523" ; oboInOwl:hasExactSynonym "Hyperostosis of lower jaw", "Hyperostosis of mandibular bone", "Increased ossification of mandibular bone" ; oboInOwl:hasRelatedSynonym "Increased ossification of lower jaw", "Increased ossification of mandible" ; oboInOwl:id "HP:0004472" ; a owl:Class ; rdfs:comment "This bundled term will be made obsolete in future versions of the HPO." ; rdfs:label "Mandibular hyperostosis" ; rdfs:subClassOf obo:HP_0005465 . obo:HP_0004474 obo:IAO_0000115 "The anterior fontanelle generally ossifies by around the 18th month of life. A persistent open anterior fontanelle is diagnosed if closure is delayed beyond this age." ; oboInOwl:hasAlternativeId "HP:0004475", "HP:0004483" ; oboInOwl:hasDbXref "UMLS:C1849537" ; oboInOwl:hasExactSynonym "Front fontanelle stays open", "Persistent, open anterior fontanel" ; oboInOwl:hasRelatedSynonym "Anterior fontanelle open in adults" ; oboInOwl:id "HP:0004474" ; a owl:Class ; rdfs:label "Persistent open anterior fontanelle" ; rdfs:subClassOf obo:HP_0001476 . obo:HP_0004476 obo:IAO_0000115 "A developmental defect resulting in the congenital absence of skin on the scalp in the parietal area." ; oboInOwl:hasDbXref "UMLS:C1863492" ; oboInOwl:hasExactSynonym "Absent cutis congenita over parietal area" ; oboInOwl:id "HP:0004476" ; a owl:Class ; rdfs:label "Aplasia cutis congenita over parietal area" ; rdfs:subClassOf obo:HP_0007385 . obo:HP_0004478 oboInOwl:hasDbXref "UMLS:C1843495" ; oboInOwl:id "HP:0004478" ; a owl:Class ; rdfs:label "Ethmoidal encephalocele" ; rdfs:subClassOf obo:HP_0011817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004481 obo:IAO_0000115 "The progressive development of an abnormally large skull." ; oboInOwl:hasAlternativeId "HP:0000261" ; oboInOwl:hasDbXref "UMLS:C1859896" ; oboInOwl:hasExactSynonym "Macrocephaly, progressive", "Progressively abnormally enlarging cranium", "Progressively abnormally enlarging skull" ; oboInOwl:id "HP:0004481" ; a owl:Class ; rdfs:label "Progressive macrocephaly" ; rdfs:subClassOf obo:HP_0000256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0004482 obo:IAO_0000115 "A relatively mild degree of macrocephaly in which the head circumference is not above two standard deviations from the mean, but appears dysproportionately large when other factors such as body stature are taken into account." ; oboInOwl:hasAlternativeId "HP:0000257", "HP:0001364" ; oboInOwl:hasDbXref "SNOMEDCT_US:3961000119101", "UMLS:C1849075" ; oboInOwl:hasExactSynonym "Disproportionately large head", "Macrocephaly, relative", "Relatively large head" ; oboInOwl:id "HP:0004482" ; a owl:Class ; rdfs:label "Relative macrocephaly" ; rdfs:subClassOf obo:HP_0000256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000256 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004484 obo:IAO_0000115 "Asymmetry of the bones of the skull and the face." ; oboInOwl:hasDbXref "UMLS:C4025320" ; oboInOwl:hasExactSynonym "Uneven craniofacial structures" ; oboInOwl:hasRelatedSynonym "Abnormality of craniofacial shape", "Malformation of craniofacial shape" ; oboInOwl:id "HP:0004484" ; a owl:Class ; rdfs:label "Craniofacial asymmetry" ; rdfs:subClassOf obo:HP_0000267, obo:HP_0000324, obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011156 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004485 obo:IAO_0000115 "Stagnation of head growth seen as flattening of the head circumference curve." ; oboInOwl:hasBroadSynonym "Skull stopped growing" ; oboInOwl:hasDbXref "UMLS:C4025319" ; oboInOwl:hasExactSynonym "Cranium stopped growing", "Head stopped growing" ; oboInOwl:id "HP:0004485" ; a owl:Class ; rdfs:label "Cessation of head growth" ; rdfs:subClassOf obo:HP_0005484 . obo:HP_0004487 obo:IAO_0000115 "An abnormality of head shape characterized by the presence of a short, wide head as well as a pointy or conical form of the top of the head owing to premature closure of the coronal and lambdoid sutures." ; oboInOwl:hasDbXref "SNOMEDCT_US:711039004", "UMLS:C1863395" ; oboInOwl:id "HP:0004487" ; a owl:Class ; rdfs:label "Acrobrachycephaly" ; rdfs:subClassOf obo:HP_0000248 . obo:HP_0004488 obo:IAO_0000115 "The presence of an abnormally large skull with onset at birth." ; oboInOwl:hasBroadSynonym "Big head present at birth", "Big head present since birth", "Congenital large head", "Large head present at birth", "Large head present since birth" ; oboInOwl:hasDbXref "UMLS:C1836599" ; oboInOwl:hasExactSynonym "Big cranium present at birth", "Big cranium present since birth", "Big skull present at birth", "Big skull present since birth", "Congenital large cranium", "Congenital large skull", "Congenital macrocephaly", "Head circumference large for gestational age", "Large cranium present at birth", "Large cranium present since birth", "Large skull present at birth", "Large skull present since birth" ; oboInOwl:id "HP:0004488" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Macrocephaly at birth" ; rdfs:subClassOf obo:HP_0000256 . obo:HP_0004490 obo:IAO_0000115 "Excessive growth of the calvaria." ; oboInOwl:hasBroadSynonym "Enlargement of calvarial bones", "Excessive growth of calvarial bones", "Hypertrophy of calvarial bones", "Overgrowth of calvarial bones", "Thick calvarial bones" ; oboInOwl:hasDbXref "MSH:C537963", "UMLS:C1863351", "UMLS:C4280519", "UMLS:C4280520" ; oboInOwl:hasExactSynonym "Hyperostosis of calvarial bones", "Increased ossification of calvarial bones", "Overgrowth of skullcap" ; oboInOwl:id "HP:0004490" ; a owl:Class ; rdfs:comment "The calvaria (skull cap) is made up of the frontal, occipital, right and left parietal, right and left temporal, sphenoid, and ethmoid bones, and thus comprises the upper dome-like part of the skull and does not include the lower jaw." ; rdfs:label "Calvarial hyperostosis" ; rdfs:subClassOf obo:HP_0004437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004491 obo:IAO_0000115 "An enlargement of the posterior fontanelle relative to age-dependent norms." ; oboInOwl:hasDbXref "UMLS:C1855233" ; oboInOwl:hasExactSynonym "Large posterior fontanel" ; oboInOwl:id "HP:0004491" ; a owl:Class ; rdfs:label "Large posterior fontanelle" ; rdfs:subClassOf obo:HP_0000239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004492 obo:IAO_0000115 "An abnormally increased width of the cranial fontanelles and sutures." ; oboInOwl:hasAlternativeId "HP:0002646", "HP:0005492" ; oboInOwl:hasDbXref "UMLS:C1849300" ; oboInOwl:hasExactSynonym "Widely patent fontanels and sutures" ; oboInOwl:id "HP:0004492" ; a owl:Class ; rdfs:comment "This term indicates that both the fontanelles and the sutures are widely patent and thus represents a severe form of delay in closure of the fontanelles/sutures." ; rdfs:label "Widely patent fontanelles and sutures" ; rdfs:subClassOf obo:HP_0000239, obo:HP_0010537 . obo:HP_0004493 obo:IAO_0000115 "Excessive growth of the craniofacial bones." ; oboInOwl:hasBroadSynonym "Enlargement of craniofacial bones", "Excessive growth of craniofacial bones", "Hypertrophy of craniofacial bones", "Overgrowth of craniofacial bones", "Thick craniofacial bones" ; oboInOwl:hasDbXref "UMLS:C1868085", "UMLS:C4280516", "UMLS:C4280517", "UMLS:C4280518" ; oboInOwl:hasExactSynonym "Excessive bone growth of the skull and face", "Hyperostosis of craniofacial bones", "Increased ossification of craniofacial bones" ; oboInOwl:id "HP:0004493" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Craniofacial hyperostosis" ; rdfs:subClassOf obo:HP_0000271, obo:HP_0004437, obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011156 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004495 obo:IAO_0100001 "HP:0000463" ; oboInOwl:id "HP:0004495" ; a owl:Class ; rdfs:label "obsolete Thin anteverted nares" ; owl:deprecated true . obo:HP_0004496 obo:IAO_0100001 "HP:0000453" ; oboInOwl:id "HP:0004496" ; a owl:Class ; rdfs:label "obsolete Posterior choanal atresia" ; owl:deprecated true . obo:HP_0004499 oboInOwl:hasDbXref "UMLS:C4025318" ; oboInOwl:hasExactSynonym "Chronic nasal inflammation due to narrow nasal airway" ; oboInOwl:id "HP:0004499" ; a owl:Class ; rdfs:label "Chronic rhinitis due to narrow nasal airway" ; rdfs:subClassOf obo:HP_0002257 . obo:HP_0004502 obo:IAO_0000115 "Bilateral absence (atresia) of the posterior nasal aperture (choana)." ; oboInOwl:hasDbXref "UMLS:C4025317" ; oboInOwl:hasExactSynonym "Bilateral blockage of the rear opening of the nasal cavity", "Bilateral obstruction of the rear opening of the nasal cavity" ; oboInOwl:id "HP:0004502" ; a owl:Class ; rdfs:label "Bilateral choanal atresia" ; rdfs:subClassOf obo:HP_0000453 . obo:HP_0004510 obo:IAO_0000115 "Hyperplasia of the islets of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells." ; oboInOwl:hasAlternativeId "HP:0001736", "HP:0006275" ; oboInOwl:hasDbXref "UMLS:C0597167" ; oboInOwl:hasExactSynonym "Hyperplastic islets of langerhans", "Hypertrophic pancreatic islets", "Islet of Langerhans hyperplasia", "Islets of langerhans hypertrophy", "Pancreatic islet-cell hypertrophy" ; oboInOwl:id "HP:0004510" ; a owl:Class ; rdfs:comment "The islets of Langerhans contain the alpha cells (producing glucagon), beta cells (insulin and amylin), delta cells (somatostatin),PP cells (pancreatic polypeptide), and the epsilon cells (ghrelin)." ; rdfs:label "Pancreatic islet-cell hyperplasia" ; rdfs:subClassOf obo:HP_0006476 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004523 obo:IAO_0000115 "Increased length of the hairs of the eyebrows." ; oboInOwl:hasDbXref "UMLS:C3280131" ; oboInOwl:hasExactSynonym "Elongated eyebrow", "Increased horizontal length of eyebrow", "Increased transverse length of eyebrow", "Long eyebrows" ; oboInOwl:id "HP:0004523" ; a owl:Class ; rdfs:label "Long eyebrows" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004524 obo:IAO_0000115 "Reduced or lacking hair growth in the temporal region (i.e., around the temples on the side of the skull)." ; oboInOwl:hasDbXref "UMLS:C4025316" ; oboInOwl:hasExactSynonym "Reduced hair growth in temporal region" ; oboInOwl:id "HP:0004524" ; a owl:Class ; rdfs:label "Temporal hypotrichosis" ; rdfs:subClassOf obo:HP_0011361 . obo:HP_0004527 oboInOwl:hasDbXref "UMLS:C4025315" ; oboInOwl:hasExactSynonym "Large clumps of pigment irregularly distributed along hair shaft" ; oboInOwl:id "HP:0004527" ; a owl:Class ; rdfs:label "Large clumps of pigment irregularly distributed along hair shaft" ; rdfs:subClassOf obo:HP_0002220 . obo:HP_0004528 obo:IAO_0000115 "Reduced or lacking hair growth in a generalized distribution." ; oboInOwl:hasAlternativeId "HP:0004513" ; oboInOwl:hasDbXref "UMLS:C4021653" ; oboInOwl:hasExactSynonym "Generalised hypotrichosis", "Hypotrichosis, generalised", "Hypotrichosis, generalized" ; oboInOwl:id "HP:0004528" ; a owl:Class ; rdfs:label "Generalized hypotrichosis" ; rdfs:subClassOf obo:HP_0008070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0004529 oboInOwl:hasDbXref "UMLS:C4025314" ; oboInOwl:id "HP:0004529" ; a owl:Class ; rdfs:label "Atrophic, patchy alopecia" ; rdfs:subClassOf obo:HP_0002232 . obo:HP_0004532 obo:IAO_0000115 "Excessive, increased hair growth located in the sacral region." ; oboInOwl:hasDbXref "UMLS:C4025313" ; oboInOwl:id "HP:0004532" ; a owl:Class ; rdfs:label "Sacral hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0004535 obo:IAO_0000115 "Anterior cervical hypertrichosis (ACH) or 'hairy throat' refers to the presence of a tuft of terminal hair on the anterior neck, just above the laryngeal prominence." ; oboInOwl:hasAlternativeId "HP:0004517", "HP:0004773" ; oboInOwl:hasDbXref "MSH:C538390", "UMLS:C1838123" ; oboInOwl:hasExactSynonym "Congenital cervical hypertrichosis", "Hypertrichosis, congenital anterior cervical" ; oboInOwl:id "HP:0004535" ; a owl:Class ; rdfs:label "Anterior cervical hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0004540 obo:IAO_0000115 "A confluent, generalized overgrowth of silvery blonde to gray lanugo hair at birth." ; oboInOwl:hasAlternativeId "HP:0004547", "HP:0004769" ; oboInOwl:hasDbXref "MSH:C538388", "UMLS:C1855900" ; oboInOwl:hasExactSynonym "Congenital generalised hypertrichosis", "Congenital generalized hypertrichosis", "Congenital, generalised hypertrichosis", "Hypertrichosis universalis" ; oboInOwl:id "HP:0004540" ; a owl:Class ; rdfs:comment "Hypertrichosis refers to excessive, abnormal hairiness." ; rdfs:label "Congenital, generalized hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0004544 obo:IAO_0100001 "HP:0000349" ; oboInOwl:id "HP:0004544" ; a owl:Class ; rdfs:label "obsolete Pointed frontal hairline" ; owl:deprecated true . obo:HP_0004552 oboInOwl:hasDbXref "UMLS:C3806301" ; oboInOwl:hasExactSynonym "Cicatricial alopecia" ; oboInOwl:hasRelatedSynonym "Hair loss on scalp from scarring condition" ; oboInOwl:id "HP:0004552" ; a owl:Class ; rdfs:label "Scarring alopecia of scalp" ; rdfs:subClassOf obo:HP_0000987, obo:HP_0002293 . obo:HP_0004554 obo:IAO_0000115 "Generalized excessive, abnormal hairiness." ; oboInOwl:hasAlternativeId "HP:0004543", "HP:0004766" ; oboInOwl:hasDbXref "UMLS:C3277940" ; oboInOwl:hasExactSynonym "Generalised hypertrichosis" ; oboInOwl:id "HP:0004554" ; a owl:Class ; rdfs:label "Generalized hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0004557 oboInOwl:hasDbXref "UMLS:C1969393" ; oboInOwl:id "HP:0004557" ; a owl:Class ; rdfs:label "Anterior vertebral fusion" ; rdfs:subClassOf obo:HP_0002948 . obo:HP_0004558 obo:IAO_0000115 "A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the cervical spine." ; oboInOwl:hasAlternativeId "HP:0005641" ; oboInOwl:hasDbXref "UMLS:C1856641" ; oboInOwl:hasExactSynonym "Flattened cervical vertebral bodies" ; oboInOwl:id "HP:0004558" ; a owl:Class ; rdfs:label "Cervical platyspondyly" ; rdfs:subClassOf obo:HP_0000926, obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004562 oboInOwl:hasDbXref "UMLS:C1854941" ; oboInOwl:id "HP:0004562" ; a owl:Class ; rdfs:label "Beaking of vertebral bodies T12-L3" ; rdfs:subClassOf obo:HP_0004568 . obo:HP_0004563 obo:IAO_0000115 "Increased bone density affecting the bones of the spine (vertebral column)." ; oboInOwl:hasDbXref "UMLS:C4020828", "UMLS:C4280254", "UMLS:C4280513", "UMLS:C4280514", "UMLS:C4280515" ; oboInOwl:hasExactSynonym "Increased density of spinal bone", "Ivory spinal bone" ; oboInOwl:hasRelatedSynonym "Compact spinal bone", "Concrete spinal bone", "Dense spinal bone", "Eburnation of spinal bone", "Increased spinal bone density Z-score", "Sclerosis of spinal bone" ; oboInOwl:id "HP:0004563" ; a owl:Class ; rdfs:label "Increased spinal bone density" ; rdfs:subClassOf obo:HP_0004330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004565 oboInOwl:hasAlternativeId "HP:0004564" ; oboInOwl:hasDbXref "UMLS:C1850293" ; oboInOwl:hasExactSynonym "platyspondyly, extreme" ; oboInOwl:id "HP:0004565" ; a owl:Class ; rdfs:label "Severe platyspondyly" ; rdfs:subClassOf obo:HP_0000926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000926 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004566 obo:IAO_0000115 "Bulbous appearance of the anterior vertebral bodies, such that the vertebral bodies have the greatest vertical height anteriorly as well as bulbous anterior superior-inferior contours." ; oboInOwl:hasDbXref "UMLS:C1866731" ; oboInOwl:hasExactSynonym "Pear-shaped vertebral bodies" ; oboInOwl:id "HP:0004566" ; a owl:Class ; rdfs:label "Pear-shaped vertebrae" ; rdfs:subClassOf obo:HP_0003312 . obo:HP_0004568 obo:IAO_0000115 "Anterior tongue-like protrusions of the vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0003313", "HP:0003315", "HP:0004569", "HP:0004577", "HP:0004584", "HP:0005122" ; oboInOwl:hasDbXref "SNOMEDCT_US:19888007", "UMLS:C0264112", "UMLS:C1856599" ; oboInOwl:hasExactSynonym "Anterior beaking of vertebrae", "Anterior beaking of vertebral bodies", "Beaked vertebral bodies", "Vertebral tongue-like protrusion", "anterior beaking" ; oboInOwl:id "HP:0004568" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Beaking of vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001955 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004570 obo:IAO_0000115 "Increased top to bottom height of vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0005693" ; oboInOwl:hasDbXref "UMLS:C1864853" ; oboInOwl:hasExactSynonym "Tall vertebral bodies" ; oboInOwl:id "HP:0004570" ; a owl:Class ; rdfs:label "Increased vertebral height" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004571 oboInOwl:hasDbXref "UMLS:C3807591" ; oboInOwl:id "HP:0004571" ; a owl:Class ; rdfs:label "Widening of cervical spinal canal" ; rdfs:subClassOf obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006692 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004573 obo:IAO_0000115 "An abnormality of the shape of the thoracic vertebra T11 such that it is wedge-shaped (narrow towards the front)." ; oboInOwl:hasDbXref "UMLS:C4021652" ; oboInOwl:hasExactSynonym "Anterior wedging of the 11th thoracic vertebra", "Wedge-shaped 11th thoracic vertebra" ; oboInOwl:id "HP:0004573" ; a owl:Class ; rdfs:label "Anterior wedging of T11" ; rdfs:subClassOf obo:HP_0008422 . obo:HP_0004575 oboInOwl:hasDbXref "UMLS:C1847394" ; oboInOwl:id "HP:0004575" ; a owl:Class ; rdfs:label "Fusion of midcervical facet joints" ; rdfs:subClassOf obo:HP_0002949 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016404 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004576 obo:IAO_0000115 "Sclerosis (increased density) affecting vertebral end plates." ; oboInOwl:hasDbXref "UMLS:C1859698" ; oboInOwl:hasExactSynonym "Endplate sclerosis" ; oboInOwl:id "HP:0004576" ; a owl:Class ; rdfs:label "Sclerotic vertebral endplates" ; rdfs:subClassOf obo:HP_0005106 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004580 obo:IAO_0000115 "An excessive concavity of the anterior surface of one or more vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C2673652" ; oboInOwl:hasRelatedSynonym "Anterior scalloping vertebral bodies" ; oboInOwl:id "HP:0004580" ; a owl:Class ; rdfs:comment "One cause of anterior scalloping is an aortic aneurysm, which because of its pulsatile pressure can cause a convex defect along the anterior surface of an adjacent vertebra body. The defect may have a sclerotic margin." ; rdfs:label "Anterior scalloping of vertebral bodies" ; rdfs:subClassOf obo:HP_0004586 . obo:HP_0004581 oboInOwl:hasDbXref "UMLS:C1866732" ; oboInOwl:id "HP:0004581" ; a owl:Class ; rdfs:label "Increased anterior vertebral height" ; rdfs:subClassOf obo:HP_0004570 . obo:HP_0004582 oboInOwl:hasDbXref "UMLS:C4025311" ; oboInOwl:id "HP:0004582" ; a owl:Class ; rdfs:label "Irregularity of vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004586 obo:IAO_0000115 "Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward." ; oboInOwl:hasAlternativeId "HP:0002952", "HP:0004561", "HP:0004620" ; oboInOwl:hasDbXref "UMLS:C1856087" ; oboInOwl:hasExactSynonym "Biconcave 'codfish' vertebrae", "Biconcave vertebrae", "Codfish vertebrae", "Fish vertebrae", "Scalloping of vertebral bodies" ; oboInOwl:id "HP:0004586" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding has been called fish or codfish vertebra because of the characteristic biconcave form of fish vertebral bodies." ; rdfs:label "Biconcave vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002039 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004589 oboInOwl:hasDbXref "UMLS:C4025310" ; oboInOwl:id "HP:0004589" ; a owl:Class ; rdfs:label "Dysplasia of second lumbar vertebra" ; rdfs:subClassOf obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004590 oboInOwl:hasDbXref "UMLS:C1970816" ; oboInOwl:hasExactSynonym "Small sacrum" ; oboInOwl:id "HP:0004590" ; a owl:Class ; rdfs:label "Hypoplastic sacrum" ; rdfs:subClassOf obo:HP_0008517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004591 oboInOwl:hasDbXref "UMLS:C1835444" ; oboInOwl:id "HP:0004591" ; a owl:Class ; rdfs:label "Disc-like vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001874 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004592 obo:IAO_0000115 "A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the thoracic spine." ; oboInOwl:hasDbXref "UMLS:C1862428" ; oboInOwl:id "HP:0004592" ; a owl:Class ; rdfs:label "Thoracic platyspondyly" ; rdfs:subClassOf obo:HP_0000926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004594 oboInOwl:hasDbXref "UMLS:C1839252" ; oboInOwl:id "HP:0004594" ; a owl:Class ; rdfs:label "Hump-shaped mound of bone in central and posterior portions of vertebral endplate" ; rdfs:subClassOf obo:HP_0003301 . obo:HP_0004598 obo:IAO_0000115 "Three ossification sites are present in typical vertebral bodies (C3-L5): a single ossification center in the vertebral body, and one each in the two neural arches. This term applies if there are additional vertebral ossification centers present during the development and maturation of the spine." ; oboInOwl:hasDbXref "UMLS:C4025309" ; oboInOwl:hasExactSynonym "Supernumerary vertebral ossification centres" ; oboInOwl:id "HP:0004598" ; a owl:Class ; rdfs:label "Supernumerary vertebral ossification centers" ; rdfs:subClassOf obo:HP_0000926, obo:HP_0100569 . obo:HP_0004599 oboInOwl:hasDbXref "UMLS:C1832983" ; oboInOwl:id "HP:0004599" ; a owl:Class ; rdfs:label "Absent or minimally ossified vertebral bodies" ; rdfs:subClassOf obo:HP_0100569 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0004606 obo:HP_0100856 ) ] ] . obo:HP_0004601 obo:IAO_0000115 "The closed form of spina bifida with incomplete closure of the vertebra L5 with intact overlying skin." ; oboInOwl:hasDbXref "UMLS:C4025308" ; oboInOwl:id "HP:0004601" ; a owl:Class ; rdfs:label "Spina bifida occulta at L5" ; rdfs:subClassOf obo:HP_0003298 . obo:HP_0004602 obo:IAO_0000115 "Fusion of cervical vertebrae at C2 and C3, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine." ; oboInOwl:hasAlternativeId "HP:0004636" ; oboInOwl:hasDbXref "MSH:D007714", "SNOMEDCT_US:388981000", "SNOMEDCT_US:5601008", "UMLS:C0022738" ; oboInOwl:hasExactSynonym "Fusion of cervical vertebrae c2-3", "Klippel-Feil anomaly", "Klippel-Feil syndrome" ; oboInOwl:id "HP:0004602" ; a owl:Class ; rdfs:label "Cervical C2/C3 vertebral fusion" ; rdfs:subClassOf obo:HP_0002949 . obo:HP_0004603 oboInOwl:hasDbXref "UMLS:C4025307" ; oboInOwl:id "HP:0004603" ; a owl:Class ; rdfs:label "Hyperconvex vertebral body endplates" ; rdfs:subClassOf obo:HP_0005106 . obo:HP_0004605 obo:IAO_0000115 "A lack of bone mineralization of the vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C1860191" ; oboInOwl:id "HP:0004605" ; a owl:Class ; rdfs:label "Absent vertebral body mineralization" ; rdfs:subClassOf obo:HP_0004599 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030282 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001075 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004606 obo:IAO_0000115 "A lack of ossification of the vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0008427" ; oboInOwl:hasDbXref "UMLS:C1860202" ; oboInOwl:id "HP:0004606" ; a owl:Class ; rdfs:label "Unossified vertebral bodies" ; rdfs:subClassOf obo:HP_0004599 ; owl:equivalentClass _:genid53004 . obo:HP_0004607 obo:IAO_0000115 "Anterior tongue-like protrusions of the lower thoracic vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C4025306" ; oboInOwl:id "HP:0004607" ; a owl:Class ; rdfs:label "Anterior beaking of lower thoracic vertebrae" ; rdfs:subClassOf obo:HP_0004568 . obo:HP_0004608 obo:IAO_0000115 "Anterior mislocalization of the dens of the axis." ; oboInOwl:hasDbXref "UMLS:C1844512" ; oboInOwl:id "HP:0004608" ; a owl:Class ; rdfs:label "Anteriorly placed odontoid process" ; rdfs:subClassOf obo:HP_0003310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001921 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004096 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004609 oboInOwl:hasDbXref "UMLS:C4025305" ; oboInOwl:id "HP:0004609" ; a owl:Class ; rdfs:label "Patchy distortion of vertebrae" ; rdfs:subClassOf obo:HP_0003312 . obo:HP_0004610 obo:IAO_0000115 "An abnormal narrowing of the lumbar spinal canal." ; oboInOwl:hasDbXref "SNOMEDCT_US:18347007", "UMLS:C0158288" ; oboInOwl:hasExactSynonym "Lumbar spinal stenosis", "Narrow lumbar spinal canal" ; oboInOwl:id "HP:0004610" ; a owl:Class ; rdfs:comment "Symptoms of lumbar spinal canal stenosis include pseudoclaudication (pain, numbness,, or weakness induced by walking and relieved by rest; the prefix pseudo is used to differentiate this manifestation from claudication, which has similar symptoms but is caused by peripheral artery disease)." ; rdfs:label "Lumbar spinal canal stenosis" ; rdfs:subClassOf obo:HP_0003416 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014543 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004611 oboInOwl:hasDbXref "UMLS:C1839822" ; oboInOwl:hasExactSynonym "Anteriorly concave vertebrae" ; oboInOwl:id "HP:0004611" ; a owl:Class ; rdfs:label "Anterior concavity of thoracic vertebrae" ; rdfs:subClassOf obo:HP_0003312 . obo:HP_0004614 obo:IAO_0000115 "The closed form of spina bifida with incomplete closure of S1 with intact overlying skin." ; oboInOwl:hasDbXref "UMLS:C4025304" ; oboInOwl:id "HP:0004614" ; a owl:Class ; rdfs:label "Spina bifida occulta at S1" ; rdfs:subClassOf obo:HP_0003298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017671 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004616 obo:IAO_0000115 "A discontinuity of the vertebral arch, i.e., of the posterior part of a vertebra." ; oboInOwl:hasDbXref "UMLS:C1859458" ; oboInOwl:hasRelatedSynonym "Cleft vertebral arches" ; oboInOwl:id "HP:0004616" ; a owl:Class ; rdfs:label "Cleft vertebral arch" ; rdfs:subClassOf obo:HP_0008438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004617 obo:IAO_0000115 "Butterfly vertebrae have a cleft through the body of the vertebrae and a funnel shape at the ends." ; oboInOwl:hasDbXref "UMLS:C1861627" ; oboInOwl:id "HP:0004617" ; a owl:Class ; rdfs:label "Butterfly vertebral arch" ; rdfs:subClassOf obo:HP_0008438 . obo:HP_0004618 oboInOwl:hasDbXref "UMLS:C1850134" ; oboInOwl:id "HP:0004618" ; a owl:Class ; rdfs:label "Sandwich appearance of vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 . obo:HP_0004619 oboInOwl:hasDbXref "UMLS:C1834953" ; oboInOwl:id "HP:0004619" ; a owl:Class ; rdfs:label "Lumbar kyphoscoliosis" ; rdfs:subClassOf obo:HP_0002751, obo:HP_0004626, obo:HP_0008454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002751 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004621 obo:IAO_0000115 "Increased size of the vertebral pedicle." ; oboInOwl:hasDbXref "UMLS:C4025303" ; oboInOwl:hasExactSynonym "Hyperplastic vertebral pedicles" ; oboInOwl:id "HP:0004621" ; a owl:Class ; rdfs:comment "The vertebral pedicles are the two short, thick processes, which connect the body of the spinal vertebra to the arch." ; rdfs:label "Enlarged vertebral pedicles" ; rdfs:subClassOf obo:HP_0030277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004622 obo:IAO_0000115 "A progressive form of decreased height of the intervertebral disk." ; oboInOwl:hasDbXref "UMLS:C1837670" ; oboInOwl:id "HP:0004622" ; a owl:Class ; rdfs:label "Progressive intervertebral space narrowing" ; rdfs:subClassOf obo:HP_0002945 . obo:HP_0004625 obo:IAO_0000115 "Presence of abnormal convexity of the upper and lower end plates of the vertebrae, i.e., an exaggerated bulging out of the upper and lower vertebral end plates." ; oboInOwl:hasDbXref "UMLS:C1866675" ; oboInOwl:id "HP:0004625" ; a owl:Class ; rdfs:comment "Note that biconvex vertebral bodies can be a normal finding in newborns." ; rdfs:label "Biconvex vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002040 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004626 oboInOwl:hasDbXref "UMLS:C2748518" ; oboInOwl:id "HP:0004626" ; a owl:Class ; rdfs:label "Lumbar scoliosis" ; rdfs:subClassOf obo:HP_0002944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004629 obo:IAO_0000115 "Reduced size of cervical vertebrae." ; oboInOwl:hasAlternativeId "HP:0008429" ; oboInOwl:hasDbXref "UMLS:C1851130" ; oboInOwl:hasExactSynonym "Small cervical vertebrae" ; oboInOwl:id "HP:0004629" ; a owl:Class ; rdfs:label "Small cervical vertebral bodies" ; rdfs:subClassOf obo:HP_0008479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004630 obo:IAO_0000115 "Anterior tongue-like protrusions of thoracic vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C4025302" ; oboInOwl:id "HP:0004630" ; a owl:Class ; rdfs:label "Anterior beaking of thoracic vertebrae" ; rdfs:subClassOf obo:HP_0004568 . obo:HP_0004631 oboInOwl:hasBroadSynonym "Inability to touch chin to chest" ; oboInOwl:hasDbXref "UMLS:C1839653", "UMLS:C4280512" ; oboInOwl:hasExactSynonym "Contracture of post-cervical muscles" ; oboInOwl:id "HP:0004631" ; a owl:Class ; rdfs:label "Decreased cervical spine flexion due to contractures of posterior cervical muscles" ; rdfs:subClassOf obo:HP_0001371 . obo:HP_0004632 obo:IAO_0000115 "An abnormality related to a defect of vertebral separation of cervical vertebrae during development." ; oboInOwl:hasAlternativeId "HP:0004612" ; oboInOwl:hasDbXref "UMLS:C1862415" ; oboInOwl:hasExactSynonym "Cervical spine segmentation defect" ; oboInOwl:id "HP:0004632" ; a owl:Class ; rdfs:label "Cervical segmentation defect" ; rdfs:subClassOf obo:HP_0003422 . obo:HP_0004633 obo:IAO_0000115 "Over curvature of the lower thoracic region, leading to a round back or if sever to a hump." ; oboInOwl:hasDbXref "UMLS:C1864361" ; oboInOwl:hasExactSynonym "Round mid-back" ; oboInOwl:id "HP:0004633" ; a owl:Class ; rdfs:label "Lower thoracic kyphosis" ; rdfs:subClassOf obo:HP_0002942 . obo:HP_0004634 oboInOwl:hasDbXref "UMLS:C2673653" ; oboInOwl:hasExactSynonym "Cuboid vertebral bodies" ; oboInOwl:id "HP:0004634" ; a owl:Class ; rdfs:label "Cuboid-shaped vertebral bodies" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001872 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004635 obo:IAO_0000115 "Fusion of the C5 and C6 cervical vertebrae." ; oboInOwl:hasDbXref "UMLS:C4025301" ; oboInOwl:id "HP:0004635" ; a owl:Class ; rdfs:label "Cervical C5/C6 vertebrae fusion" ; rdfs:subClassOf obo:HP_0002949 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004614 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004615 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004637 oboInOwl:hasDbXref "UMLS:C1859692" ; oboInOwl:hasExactSynonym "Limited neck movement" ; oboInOwl:id "HP:0004637" ; a owl:Class ; rdfs:label "Decreased cervical spine mobility" ; rdfs:subClassOf obo:HP_0003319 . obo:HP_0004639 obo:IAO_0000115 "An elevation of alpha-feto protein measured in the amniotic fluid." ; oboInOwl:hasAlternativeId "HP:0005985" ; oboInOwl:hasDbXref "UMLS:C1839860" ; oboInOwl:hasExactSynonym "Elevated amniotic fluid alpha fetal protein", "Elevated amniotic fluid alpha foetal protein", "Elevated amniotic fluid alpha-1-fetoprotein", "Elevated amniotic fluid alpha-fetoglobulin" ; oboInOwl:id "HP:0004639" ; a owl:Class ; rdfs:comment "This feature can be found in pregnancies with fetuses affected by a range of abnormalities including for instance encephalocele." ; rdfs:label "Elevated amniotic fluid alpha-fetoprotein" ; rdfs:subClassOf obo:HP_0006254 . obo:HP_0004646 obo:IAO_0000115 "Underdevelopment of the nasal bone." ; oboInOwl:hasBroadSynonym "Small nasal bone" ; oboInOwl:hasDbXref "UMLS:C4021651" ; oboInOwl:hasExactSynonym "Decreased size of nasal bone", "Deficiency of nasal bone", "Nasal bone hypoplasia", "Underdevelopment of nasal bone" ; oboInOwl:hasRelatedSynonym "Hypotrophic nasal bone" ; oboInOwl:id "HP:0004646" ; a owl:Class ; rdfs:label "Hypoplasia of the nasal bone" ; rdfs:subClassOf obo:HP_0009924, obo:HP_0010940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004660 obo:IAO_0000115 "Underdevelopment of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." ; oboInOwl:hasBroadSynonym "Small facial muscles" ; oboInOwl:hasDbXref "UMLS:C1834042", "UMLS:C4280509", "UMLS:C4280510", "UMLS:C4280511" ; oboInOwl:hasExactSynonym "Decreased size of facial muscles", "Deficiency of facial musculature", "Underdevelopment of facial muscles" ; oboInOwl:hasRelatedSynonym "Atrophy of facial musculature", "Hypotrophic facial musculature" ; oboInOwl:id "HP:0004660" ; a owl:Class ; rdfs:label "Hypoplasia of facial musculature" ; rdfs:subClassOf obo:HP_0000301 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004473 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004661 obo:IAO_0000115 "Reduced strength of the frontalis muscle (which is located on the forehead)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1859438" ; oboInOwl:hasExactSynonym "Weak frontalis muscle", "Weakness of forehead muscle" ; oboInOwl:id "HP:0004661" ; a owl:Class ; rdfs:label "Frontalis muscle weakness" ; rdfs:subClassOf obo:HP_0010628, obo:HP_3000004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010952 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004664 obo:IAO_0000115 "Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the midline region of the face." ; oboInOwl:hasDbXref "UMLS:C1862496" ; oboInOwl:id "HP:0004664" ; a owl:Class ; rdfs:label "Facial midline hemangioma" ; rdfs:subClassOf obo:HP_0000329 . obo:HP_0004673 obo:IAO_0000115 "A reduced degree of voluntary and involuntary facial movements involved in responded to others or expressing emotions." ; oboInOwl:hasDbXref "UMLS:C1862474" ; oboInOwl:hasExactSynonym "Decreased facial expression" ; oboInOwl:id "HP:0004673" ; a owl:Class ; rdfs:label "Decreased facial expression" ; rdfs:subClassOf obo:HP_0005346 . obo:HP_0004676 oboInOwl:hasDbXref "UMLS:C1834993" ; oboInOwl:id "HP:0004676" ; a owl:Class ; rdfs:label "Prominent supraorbital arches in adult" ; rdfs:subClassOf obo:HP_0000336 . obo:HP_0004679 oboInOwl:hasDbXref "UMLS:C1859116" ; oboInOwl:hasExactSynonym "Large ankle bones" ; oboInOwl:id "HP:0004679" ; a owl:Class ; rdfs:label "Large tarsal bones" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004681 obo:IAO_0000115 "Narrow, paramedian longitudinal depressions in the plantar skin of the forefoot." ; oboInOwl:hasBroadSynonym "Foot crease" ; oboInOwl:hasDbXref "UMLS:C1859223", "UMLS:C4280508" ; oboInOwl:hasExactSynonym "Longitudinal groove on soles" ; oboInOwl:id "HP:0004681" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Deep longitudinal plantar crease" ; rdfs:subClassOf obo:HP_0001869 . obo:HP_0004684 obo:IAO_0000115 "Outward turning of the heel, resulting in clubfoot with the person walking on the inner part of the foot." ; oboInOwl:hasDbXref "SNOMEDCT_US:79807003", "UMLS:C0152236" ; oboInOwl:id "HP:0004684" ; a owl:Class ; rdfs:comment "The phrase talipes valgus is derived from the Latin words talus (ankle), pes (poot), and valgus (outward angulation of the distal segment of a bone)." ; rdfs:label "Talipes valgus" ; rdfs:subClassOf obo:HP_0034673 . obo:HP_0004686 obo:IAO_0000115 "Underdevelopment of the Third metatarsal bone leading to a short (hypoplastic) third metatarsal bone." ; oboInOwl:hasAlternativeId "HP:0010673" ; oboInOwl:hasDbXref "UMLS:C4021650" ; oboInOwl:hasExactSynonym "Hypoplasia of the 3rd metatarsal bone", "Short 3rd long bone of foot" ; oboInOwl:id "HP:0004686" ; a owl:Class ; rdfs:label "Short third metatarsal" ; rdfs:subClassOf obo:HP_0010672, obo:HP_0010743 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004688 oboInOwl:hasDbXref "UMLS:C1855240" ; oboInOwl:hasExactSynonym "Abnormal shape of ankle bones" ; oboInOwl:id "HP:0004688" ; a owl:Class ; rdfs:label "Irregular tarsal bones" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004689 obo:IAO_0000115 "Short fourth metatarsal bone." ; oboInOwl:hasDbXref "UMLS:C1848514" ; oboInOwl:hasExactSynonym "Bilateral fourth metatarsal shortening", "Short 4th long bone of foot", "Short fourth metatarsus" ; oboInOwl:hasRelatedSynonym "Short fourth metatarsals" ; oboInOwl:id "HP:0004689" ; a owl:Class ; rdfs:label "Short fourth metatarsal" ; rdfs:subClassOf obo:HP_0010743, obo:HP_0040035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003653 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004690 obo:IAO_0000115 "An abnormal thickening of the Achilles tendon." ; oboInOwl:hasDbXref "UMLS:C0919997" ; oboInOwl:hasExactSynonym "Thickened Achilles tendon" ; oboInOwl:id "HP:0004690" ; a owl:Class ; rdfs:label "Thickened Achilles tendon" ; rdfs:subClassOf obo:HP_0005109 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004691 obo:IAO_0000115 "Syndactyly with fusion of toes two and three." ; oboInOwl:hasAlternativeId "HP:0001846", "HP:0001856", "HP:0003773", "HP:0004683", "HP:0004685", "HP:0004697", "HP:0004703", "HP:0008086", "HP:0008123" ; oboInOwl:hasDbXref "SNOMEDCT_US:205145001", "UMLS:C0432040" ; oboInOwl:hasExactSynonym "2-3 syndactyly of feet", "2-3 toe soft tissue syndactyly", "2-3 toes syndactyly", "Syndactyly of second and third toes", "Toe syndactyly, 2-3", "Webbed 2nd and 3rd toes", "partial or complete syndactyly 2nd-3rd toes" ; oboInOwl:id "HP:0004691" ; a owl:Class ; rdfs:label "2-3 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004692 obo:IAO_0000115 "Syndactyly with fusion of toes four and five." ; oboInOwl:hasAlternativeId "HP:0005826", "HP:0005861" ; oboInOwl:hasDbXref "UMLS:C1837836" ; oboInOwl:hasExactSynonym "Symmetric syndactyly, toes 4 and 5", "Syndactyly of toes 4 and 5", "Webbed 4th-5th toes" ; oboInOwl:id "HP:0004692" ; a owl:Class ; rdfs:label "4-5 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004695 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the calcaneus." ; oboInOwl:hasDbXref "UMLS:C1861708" ; oboInOwl:id "HP:0004695" ; a owl:Class ; rdfs:label "Calcaneal epiphyseal stippling" ; rdfs:subClassOf obo:HP_0010655 . obo:HP_0004696 oboInOwl:hasDbXref "UMLS:C1832342" ; oboInOwl:id "HP:0004696" ; a owl:Class ; rdfs:label "Talipes cavus equinovarus" ; rdfs:subClassOf obo:HP_0001762 . obo:HP_0004699 obo:IAO_0000115 "Decrease in mass and density of the metatarsal bones." ; oboInOwl:hasDbXref "UMLS:C1836873" ; oboInOwl:id "HP:0004699" ; a owl:Class ; rdfs:label "Osteoporotic metatarsal" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004704 obo:IAO_0000115 "Short (hypoplastic) fifth metatarsal bone." ; oboInOwl:hasAlternativeId "HP:0004702", "HP:0010671" ; oboInOwl:hasDbXref "UMLS:C4021649" ; oboInOwl:hasExactSynonym "Hypoplasia of the fifth metatarsal bone", "Short 5th long bone of foot" ; oboInOwl:id "HP:0004704" ; a owl:Class ; rdfs:label "Short fifth metatarsal" ; rdfs:subClassOf obo:HP_0008089, obo:HP_0010743 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003654 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004712 obo:IAO_0000115 "An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney." ; oboInOwl:hasAlternativeId "HP:0004730" ; oboInOwl:hasDbXref "SNOMEDCT_US:49008000", "UMLS:C0238210" ; oboInOwl:hasExactSynonym "Abnormal rotation of the kidneys", "Malrotation of the kidney" ; oboInOwl:id "HP:0004712" ; a owl:Class ; rdfs:comment "The final kidney position in the renal fossa results from the rotation of the kidney with an orientation of the renal pelvis to the medial and the renal calyces to the lateral. Malrotation of the kidney can lead to orientation of the renal pelvis anteriorly, posteriorly and laterally. In most cases, renal malrotation does not cause any symptoms, but, hydronephrosis or stone formation can be observed as complications of renal malformation." ; rdfs:label "Renal malrotation" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004713 obo:IAO_0000115 "Acute renal failure with resolution of manifestations." ; oboInOwl:hasDbXref "UMLS:C1843276" ; oboInOwl:hasExactSynonym "Reversible kidney failure", "Reversible renal failure" ; oboInOwl:id "HP:0004713" ; a owl:Class ; rdfs:label "Reversible renal failure" ; rdfs:subClassOf obo:HP_0000083 . obo:HP_0004717 obo:IAO_0000115 "An abnormality of the normal developmental rotation of the kidney leading to an abnormal axial orientation of the kidney." ; oboInOwl:hasDbXref "UMLS:C4025300" ; oboInOwl:id "HP:0004717" ; a owl:Class ; rdfs:label "Axial malrotation of the kidney" ; rdfs:subClassOf obo:HP_0004712 . obo:HP_0004719 obo:IAO_0000115 "An increase in amplitude of waves returned in ultrasonography of the kidney, which is generally displayed as increased brightness of the signal." ; oboInOwl:hasDbXref "UMLS:C3275899" ; oboInOwl:hasExactSynonym "Echogenic kidneys", "Increased echogenicity of the renal parenchyma" ; oboInOwl:id "HP:0004719" ; a owl:Class ; rdfs:comment "Normal renal parenchyma is similar (isoechoic) or slightly darker (hypoechoic) compared with liver and includes the cortex and medulla. The thickness of the renal cortex is measured from the outer border of the medullary pyramids (yellow line) or from the arcuate arteries to the renal capsule. The medullary pyramids (white arrow) contain fluid in parallel tubules, which is anechoic (black) and appear as regularly spaced dark pools at the inner margin of the parenchyma (arrow). Because fat is echogenic, the central renal sinus appears bright." ; rdfs:label "Hyperechogenic kidneys" ; rdfs:subClassOf obo:HP_0033130 . obo:HP_0004722 obo:IAO_0000115 "Prominent glomerular basement membrane (GBM), reflecting an increase in thickness (subjective estimate) of the basal lamina of the glomerulus of the kidney." ; obo:RO_0002581 "Thickening of the glomerular basement membrane" ; oboInOwl:hasDbXref "SNOMEDCT_US:264932002", "UMLS:C0445347" ; oboInOwl:id "HP:0004722" ; a owl:Class ; rdfs:comment "This finding is demonstrated on renal biopsy." ; rdfs:label "Thickened glomerular basement membrane" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0004724 obo:IAO_0000115 "The presence of calcium-containing calculi (stones) in the kidneys." ; oboInOwl:hasDbXref "UMLS:C1855801" ; oboInOwl:hasExactSynonym "Ca kidney stone", "Ca nephrolithiasis", "Ca2+ kidney stone", "Ca2+ nephrolithiasis", "Calcium kidney stone" ; oboInOwl:id "HP:0004724" ; a owl:Class ; rdfs:comment "The overwhelming majority of renal calculi contain calcium." ; rdfs:label "Calcium nephrolithiasis" ; rdfs:subClassOf obo:HP_0000787 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000787 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:MPATH_36 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004727 obo:IAO_0000115 "A defect in the ability to concentrate the urine." ; oboInOwl:hasAlternativeId "HP:0005568" ; oboInOwl:hasDbXref "UMLS:C1859819" ; oboInOwl:hasExactSynonym "Urine concentrating defect", "Urine concentration defect" ; oboInOwl:id "HP:0004727" ; a owl:Class ; rdfs:comment "An impairment in renal concentrating ability can be easily recognized by the maximum concentrating ability (Umax) as determined by the urine osmolality reached after a fixed period of dehydration. Inability to maximally concentrate the urine is related to one or both of two basic tubular defects: 1) a failure of maximal free-water generation by the diluting segment in the ascending limb of Henle's loop; and 2) a failure of the distal tubular epithelium to achieve maximum permeability to water during water deprivation." ; rdfs:label "Impaired renal concentrating ability" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0004729 obo:IAO_0000115 "Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." ; oboInOwl:hasDbXref "MSH:C564356", "UMLS:C1843274" ; oboInOwl:id "HP:0004729" ; a owl:Class ; rdfs:label "Acute tubulointerstitial nephritis" ; rdfs:subClassOf obo:HP_0001970 . obo:HP_0004732 obo:IAO_0000115 "A reduction in the ability of the kidneys to remove uric acid from the serum." ; oboInOwl:hasDbXref "UMLS:C1969371" ; oboInOwl:id "HP:0004732" ; a owl:Class ; rdfs:label "Impaired renal uric acid clearance" ; rdfs:subClassOf obo:HP_0011036 . obo:HP_0004734 obo:IAO_0000115 "Cysts of microscopic size confined to the cortex of the kidney." ; oboInOwl:hasAlternativeId "HP:0000814" ; oboInOwl:hasDbXref "UMLS:C1865877" ; oboInOwl:hasExactSynonym "Cortical microcysts", "Multiple renal cortical microcysts", "Multiple small renal cortical cysts" ; oboInOwl:id "HP:0004734" ; a owl:Class ; rdfs:label "Renal cortical microcysts" ; rdfs:subClassOf obo:HP_0000803 . obo:HP_0004736 obo:IAO_0000115 "A developmental anomaly in which the kidneys are fused and localized on the same side of the midline. This anomaly is thought to result from disruption of the normal embryologic migration of the kidneys." ; oboInOwl:hasDbXref "UMLS:C1835796" ; oboInOwl:hasExactSynonym "Crossed-fused renal ectopia", "Ectopic kidney with fusion" ; oboInOwl:id "HP:0004736" ; a owl:Class ; rdfs:label "Crossed fused renal ectopia" ; rdfs:subClassOf obo:HP_0000086 . obo:HP_0004737 obo:IAO_0000115 "Obliteration of the glomerular capillary lumen by increased collagenous matrix, with or without hyalinosis or foam cells. Sclerosis involves 100% of the glomerular tuft. Relative to other patent glomeruli in the sample, glomerular size is preserved, or increased/decreased by no more than 50%." ; oboInOwl:hasDbXref "UMLS:C1865276" ; oboInOwl:id "HP:0004737" ; a owl:Class ; rdfs:comment "Glomerular changes can be focal (only in some glomeruli) or diffuse (in all or almost all the glomeruli), and segmental (only a part of the glomerulus) or global (the entire glomerulus)." ; rdfs:label "Global glomerulosclerosis" ; rdfs:subClassOf obo:HP_0000096 . obo:HP_0004742 obo:IAO_0000115 "An abnormality of the renal collecting system." ; oboInOwl:hasAlternativeId "HP:0004731" ; oboInOwl:hasDbXref "UMLS:C1851303" ; oboInOwl:hasExactSynonym "Abnormal collecting system", "Abnormality of the renal collecting system", "Renal collecting system anomalies" ; oboInOwl:id "HP:0004742" ; a owl:Class ; rdfs:label "Abnormal renal collecting system morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004743 obo:IAO_0000115 "Chronic inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." ; oboInOwl:hasDbXref "SNOMEDCT_US:60926001", "UMLS:C0238304" ; oboInOwl:id "HP:0004743" ; a owl:Class ; rdfs:label "Chronic tubulointerstitial nephritis" ; rdfs:subClassOf obo:HP_0001970 . obo:HP_0004746 obo:IAO_0000115 "Electron dense deposits at the glomerular basement membrane," ; oboInOwl:hasDbXref "MSH:D015432", "SNOMEDCT_US:59479006", "UMLS:C0268743" ; oboInOwl:hasRelatedSynonym "Dense deposit disease", "Membranoproliferative glomerulonephritis type II" ; oboInOwl:id "HP:0004746" ; a owl:Class ; rdfs:comment "Subendothelial electron-dense deposits are a characteristc feature of dense-deposit disease." ; rdfs:label "Glomerular subendothelial electron-dense deposits" ; rdfs:subClassOf obo:HP_0030949 . obo:HP_0004749 obo:IAO_0000115 "A type of atrial arrhythmia characterized by atrial rates of between 240 and 400 beats per minute and some degree of atrioventricular node conduction block. Typically, the ventricular rate is half the atrial rate. In the EKG; atrial flutter waves are observed as sawtooth-like atrial activity. Pathophysiologically, atrial flutter is a form of atrial reentry in which there is a premature electrical impulse creates a self-propagating circuit." ; oboInOwl:hasDbXref "MSH:D001282", "SNOMEDCT_US:5370000", "UMLS:C0004239" ; oboInOwl:id "HP:0004749" ; a owl:Class ; rdfs:comment "Atrial flutter can lead to palpitations, fatigue, dyspnea, and chest pain. Atrial flutter can be paroxysmal or persistent." ; rdfs:label "Atrial flutter" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0004751 obo:IAO_0000115 "Episodes of ventricular tachycardia that have a sudden onset and ending." ; oboInOwl:hasAlternativeId "HP:0005141" ; oboInOwl:hasDbXref "SNOMEDCT_US:66657009", "UMLS:C0030591" ; oboInOwl:hasExactSynonym "Episodes of ventricular tachycardia" ; oboInOwl:id "HP:0004751" ; a owl:Class ; rdfs:label "Paroxysmal ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0004752 obo:IAO_0000115 "A form of atrioventricular (AV) dissociation (i.e., the atria and the ventricles are under the control of two separate pacemakers) with congenital onset." ; oboInOwl:hasDbXref "UMLS:C4025299" ; oboInOwl:id "HP:0004752" ; a owl:Class ; rdfs:label "Congenital atrioventricular dissociation" ; rdfs:subClassOf obo:HP_0011709 . obo:HP_0004754 obo:IAO_0000115 "Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent." ; oboInOwl:hasDbXref "SNOMEDCT_US:426749004", "SNOMEDCT_US:440028005", "UMLS:C0694539", "UMLS:C2586056" ; oboInOwl:hasRelatedSynonym "Chronic atrial fibrillation" ; oboInOwl:id "HP:0004754" ; a owl:Class ; rdfs:comment "The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time. AF itself produces changes in atrial function and structure. Note there is no precise definition of the duration of AF required to be regarded as chronic." ; rdfs:label "Permanent atrial fibrillation" ; rdfs:subClassOf obo:HP_0005110 . obo:HP_0004755 obo:IAO_0000115 "Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles." ; oboInOwl:hasDbXref "MSH:D013617", "SNOMEDCT_US:6456007", "UMLS:C0039240", "UMLS:C1698480" ; oboInOwl:hasExactSynonym "SVT", "Supraventricular tachyarrhythmia" ; oboInOwl:id "HP:0004755" ; a owl:Class ; rdfs:comment "A narrow complex (QRS width less than 120 milliseconds) reflects rapid activation of the ventricles via the normal conduction pathway, i.e. His-Purkinje system, which in turn suggests that the tachycardia originated above the AV node and is thus supraventricular." ; rdfs:label "Supraventricular tachycardia" ; rdfs:subClassOf obo:HP_0001649, obo:HP_0005115 . obo:HP_0004756 obo:IAO_0000115 "A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms)." ; oboInOwl:hasDbXref "Fyler:7160", "MSH:D017180", "SNOMEDCT_US:25569003", "UMLS:C0042514" ; oboInOwl:id "HP:0004756" ; a owl:Class ; rdfs:comment "Ventricular tachycardia (VT) is a potentially life-threatening ventricular arrhythmia that presents as a wide QRS complex tachycardia, and is defined as three or more consecutive QRS complexes with a duration longer than 120 milliseconds (ms) and a rate of 100 beats per minute or more, whereby the complexes have a ventricular origin. VT can be subdivided as follows: (i) sustained VT persists for 30 seconds or more; (ii) non-sustained VT lasts less than 30 seconds; (iii) monomorphic VT displays a uniform QRS morphology; and (iv) polymorphic VT displays QRS morphologies that variy from beat to beat. VT is observed most commonly in individuals with structural heart disease or acute myocardial infarction (MI). VT may also be observed in in the setting of drug toxicity or electrolyte abnormalities or in individuals with Mendelian disease." ; rdfs:label "Ventricular tachycardia" ; rdfs:subClassOf obo:HP_0001649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001649 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004757 obo:IAO_0000115 "Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously." ; oboInOwl:hasDbXref "MSH:D001281", "SNOMEDCT_US:282825002", "UMLS:C0235480" ; oboInOwl:hasExactSynonym "Atrial fibrillation, paroxysmal", "Intermittent atrial fibrillation", "Paroxysmal AF" ; oboInOwl:id "HP:0004757" ; a owl:Class ; rdfs:label "Paroxysmal atrial fibrillation" ; rdfs:subClassOf obo:HP_0005110 . obo:HP_0004758 obo:IAO_0000115 "Polymorphic ventricular arrhythmias of varying morphologythat do not exist under resting conditions but appear only upon physical exercise or catecholamine administration." ; oboInOwl:hasDbXref "UMLS:C4025298" ; oboInOwl:hasExactSynonym "Catecholaminergic polymorphic ventricular tachycardia", "Exercise-induced polymorphic ventricular tachycardia" ; oboInOwl:id "HP:0004758" ; a owl:Class ; rdfs:label "Effort-induced polymorphic ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0004759 oboInOwl:consider "HP:0004380" ; oboInOwl:id "HP:0004759" ; a owl:Class ; rdfs:label "obsolete Nodular calcific aortic valve disease" ; owl:deprecated true . obo:HP_0004760 oboInOwl:consider "HP:0001671" ; oboInOwl:id "HP:0004760" ; a owl:Class ; rdfs:label "obsolete Congenital septal defect" ; owl:deprecated true . obo:HP_0004761 oboInOwl:hasDbXref "UMLS:C2676505" ; oboInOwl:id "HP:0004761" ; a owl:Class ; rdfs:label "Post-angioplasty coronary artery restenosis" ; rdfs:subClassOf obo:HP_0001677 . obo:HP_0004762 obo:IAO_0000115 "Underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells." ; oboInOwl:hasAlternativeId "HP:0004951" ; oboInOwl:hasDbXref "Fyler:1821", "UMLS:C4082954" ; oboInOwl:hasExactSynonym "Heart right ventricle hypoplasia", "Small right heart chamber", "Underdeveloped right heart chamber" ; oboInOwl:id "HP:0004762" ; a owl:Class ; rdfs:label "Hypoplasia of right ventricle" ; rdfs:subClassOf obo:HP_0001707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002080 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004763 obo:IAO_0000115 "An episodic form of supraventricular tachycardia with abrupt onset and termination." ; oboInOwl:hasAlternativeId "HP:0004765" ; oboInOwl:hasBroadSynonym "Episodic rapid heart beat" ; oboInOwl:hasDbXref "SNOMEDCT_US:67198005", "UMLS:C0030590", "UMLS:C4280507" ; oboInOwl:hasExactSynonym "Episodic supraventricular tachycardia" ; oboInOwl:id "HP:0004763" ; a owl:Class ; rdfs:comment "PSVT is a term used to denote intermittent supraventricular tachycardia other than atrial fibrillation, atrial flutter and multifocal atrial tachycardia (AT). The major causes are atrioventricular reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT), and sinoatrial node reentrant tachycardia (SNRT)." ; rdfs:label "Paroxysmal supraventricular tachycardia" ; rdfs:subClassOf obo:HP_0004755 . obo:HP_0004764 obo:IAO_0000115 "Myxomatous mitral valve is defined as the presence of excess leaflet tissue and leaflet thickening greater than 5 mm, resulting in a prolapse greater than 2 mm into the left atrium on parasternal long axis view." ; oboInOwl:hasDbXref "SNOMEDCT_US:253395003", "SNOMEDCT_US:42069006", "UMLS:C0264885" ; oboInOwl:id "HP:0004764" ; a owl:Class ; rdfs:label "Myxomatous mitral valve degeneration" ; rdfs:subClassOf obo:HP_0001634 . obo:HP_0004768 obo:IAO_0000115 "Decreased number of head hairs per unit area on the anterior region of the scalp." ; oboInOwl:hasDbXref "UMLS:C1866246" ; oboInOwl:hasExactSynonym "Sparse scalp hair at front of head", "Thin scalp hair at front of head" ; oboInOwl:id "HP:0004768" ; a owl:Class ; rdfs:label "Sparse anterior scalp hair" ; rdfs:subClassOf obo:HP_0000599, obo:HP_0002209 . obo:HP_0004771 oboInOwl:hasDbXref "UMLS:C1849125" ; oboInOwl:hasExactSynonym "Premature graying of body hair", "Premature greying of body hair" ; oboInOwl:id "HP:0004771" ; a owl:Class ; rdfs:label "Premature graying of body hair" ; rdfs:subClassOf obo:HP_0002216 . obo:HP_0004779 obo:IAO_0000115 "Fragile, easily breakable scalp hair." ; oboInOwl:hasAlternativeId "HP:0004776" ; oboInOwl:hasDbXref "UMLS:C4025296" ; oboInOwl:hasExactSynonym "Brittle scalp hair" ; oboInOwl:id "HP:0004779" ; a owl:Class ; rdfs:label "Brittle scalp hair" ; rdfs:subClassOf obo:HP_0002299 . obo:HP_0004780 obo:IAO_0000115 "Excessive, increased hair growth located in the elbow region." ; oboInOwl:hasDbXref "UMLS:C4025295" ; oboInOwl:hasExactSynonym "Hairy elbow", "Hairy elbow syndrome", "Hypertrichosis cubiti", "Pilosity of elbow" ; oboInOwl:id "HP:0004780" ; a owl:Class ; rdfs:label "Elbow hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0004782 obo:IAO_0100001 "HP:0002209" ; oboInOwl:id "HP:0004782" ; a owl:Class ; rdfs:label "obsolete Hypotrichosis of the scalp" ; owl:deprecated true . obo:HP_0004783 obo:IAO_0000115 "Presence of multiple polyps in the duodenum." ; oboInOwl:hasDbXref "SNOMEDCT_US:301797007", "UMLS:C0578477" ; oboInOwl:hasExactSynonym "Multiple duodenal polyps" ; oboInOwl:id "HP:0004783" ; a owl:Class ; rdfs:label "Duodenal polyposis" ; rdfs:subClassOf obo:HP_0030256 . obo:HP_0004784 obo:IAO_0000115 "The presence of multiple juvenile polyps in the stomach and intestine. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands. Juvenile polyps are a specific type of hamartomatous polyps." ; oboInOwl:hasDbXref "UMLS:C4025294" ; oboInOwl:hasExactSynonym "Juvenile GI polyposis" ; oboInOwl:id "HP:0004784" ; a owl:Class ; rdfs:label "Juvenile gastrointestinal polyposis" ; rdfs:subClassOf obo:HP_0004390 . obo:HP_0004785 obo:IAO_0000115 "An anatomical anomaly that results from an abnormal rotation of the gut as it returns to the abdominal cavity during embryogenesis." ; oboInOwl:hasDbXref "SNOMEDCT_US:6477005", "UMLS:C0266196" ; oboInOwl:id "HP:0004785" ; a owl:Class ; rdfs:label "Malrotation of colon" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0002566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004786 oboInOwl:hasDbXref "UMLS:C4025293" ; oboInOwl:id "HP:0004786" ; a owl:Class ; rdfs:label "Jejunal diverticula" ; rdfs:subClassOf obo:HP_0002256 . obo:HP_0004787 obo:IAO_0000115 "Acute hepatitis complicated by acute liver failure with hepatic encephalopathy occurring less than 8 weeks after the onset of jaundice." ; oboInOwl:hasDbXref "SNOMEDCT_US:427044009", "UMLS:C0302809" ; oboInOwl:id "HP:0004787" ; a owl:Class ; rdfs:comment "Note that different definitions of fulminant hepatitis are used in the medical literature." ; rdfs:label "Fulminant hepatitis" ; rdfs:subClassOf obo:HP_0004448, obo:HP_0012115 . obo:HP_0004788 obo:IAO_0000115 "Fluid retention and edema in the intestine caused by a compromised lymphatic system." ; oboInOwl:hasDbXref "UMLS:C4025292" ; oboInOwl:id "HP:0004788" ; a owl:Class ; rdfs:label "Intestinal lymphedema" ; rdfs:subClassOf obo:HP_0001004, obo:HP_0005225 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001004 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004789 obo:IAO_0000115 "An inability to digest lactose." ; oboInOwl:hasDbXref "MSH:D007787", "SNOMEDCT_US:267425008", "SNOMEDCT_US:700094005", "UMLS:C0022951" ; oboInOwl:hasExactSynonym "Lactose intolerance", "Milk intolerance" ; oboInOwl:id "HP:0004789" ; a owl:Class ; rdfs:label "Lactose intolerance" ; rdfs:subClassOf obo:HP_0002024 . obo:HP_0004790 obo:IAO_0000115 "Underdevelopment of the small intestine." ; oboInOwl:hasDbXref "UMLS:C4025291" ; oboInOwl:hasExactSynonym "Underdeveloped small intestine" ; oboInOwl:id "HP:0004790" ; a owl:Class ; rdfs:label "Hypoplasia of the small intestine" ; rdfs:subClassOf obo:HP_0002244, obo:HP_0005245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002108 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004791 obo:IAO_0000115 "Defect in the epithelium of the esophagus, essentially an open sore in the lining of the esophagus." ; oboInOwl:hasDbXref "SNOMEDCT_US:30811009", "UMLS:C0151970" ; oboInOwl:hasExactSynonym "Esophagus ulcer", "Oesophagus ulcer", "Oesophagus ulceration" ; oboInOwl:id "HP:0004791" ; a owl:Class ; rdfs:label "Esophageal ulceration" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0034274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_579 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004792 obo:IAO_0000115 "The presence of a fistula between the perineum and the rectum." ; oboInOwl:hasDbXref "UMLS:C0240880" ; oboInOwl:id "HP:0004792" ; a owl:Class ; rdfs:label "Rectoperineal fistula" ; rdfs:subClassOf obo:HP_0004871, obo:HP_0100590 . obo:HP_0004794 obo:IAO_0000115 "A deviation from the normal rotation of the midgut during embryologic development with mislocalization of the small bowel." ; oboInOwl:hasDbXref "UMLS:C1860244" ; oboInOwl:hasExactSynonym "Malrotation of the small intestine" ; oboInOwl:id "HP:0004794" ; a owl:Class ; rdfs:comment "Malrotation results not only in the malposition of the bowel but also in the malfixation of the mesentery. The normally broad mesenteric attachment is shortened to a narrow pedicle that predisposes the patient to the complication of midgut volvulus." ; rdfs:label "Malrotation of small bowel" ; rdfs:subClassOf obo:HP_0002244, obo:HP_0002566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002108 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004795 obo:IAO_0000115 "Polyp-like protrusions which are histologically hamartomas located in the stomach." ; oboInOwl:hasDbXref "UMLS:C1862304" ; oboInOwl:id "HP:0004795" ; a owl:Class ; rdfs:label "Hamartomatous stomach polyps" ; rdfs:subClassOf obo:HP_0004390, obo:HP_0006753 . obo:HP_0004796 oboInOwl:hasDbXref "SNOMEDCT_US:126765001", "UMLS:C0236124" ; oboInOwl:hasExactSynonym "GI obstruction", "Gastrointestinal obstruction", "Obstruction in digestive tract" ; oboInOwl:id "HP:0004796" ; a owl:Class ; rdfs:label "Gastrointestinal obstruction" ; rdfs:subClassOf obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004797 obo:IAO_0000115 "The presence of multiple areas of atresia affecting the small intestine." ; oboInOwl:hasDbXref "UMLS:C1857476" ; oboInOwl:id "HP:0004797" ; a owl:Class ; rdfs:label "Multiple small bowel atresias" ; rdfs:subClassOf obo:HP_0011100 . obo:HP_0004798 obo:IAO_0000115 "Recurrent infection of the gastrointestinal tract." ; oboInOwl:hasDbXref "SNOMEDCT_US:715852004", "UMLS:C1854495", "UMLS:C4082764" ; oboInOwl:hasExactSynonym "Recurrent gastrointestinal infections", "Recurrent infection of the GI tract", "Recurrent infection of the gastrointestinal tract" ; oboInOwl:hasRelatedSynonym "Gastrointestinal infections", "Gastrointestinal infections, recurrent" ; oboInOwl:id "HP:0004798" ; a owl:Class ; rdfs:label "Recurrent infection of the gastrointestinal tract" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0012719 . obo:HP_0004799 oboInOwl:hasDbXref "UMLS:C4025290" ; oboInOwl:id "HP:0004799" ; a owl:Class ; rdfs:label "Jejunoileal diverticula" ; rdfs:subClassOf obo:HP_0002256 . obo:HP_0004800 oboInOwl:hasDbXref "SNOMEDCT_US:197083003", "UMLS:C0341266" ; oboInOwl:id "HP:0004800" ; a owl:Class ; rdfs:label "Duodenal diverticula" ; rdfs:subClassOf obo:HP_0002256 . obo:HP_0004802 obo:IAO_0000115 "A form of hemolytic anemia that occurs in repeated episodes." ; oboInOwl:hasDbXref "UMLS:C1859495" ; oboInOwl:hasExactSynonym "Episodic hemolysis", "Episodic hemolytic anaemia" ; oboInOwl:id "HP:0004802" ; a owl:Class ; rdfs:label "Episodic hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004804 obo:IAO_0000115 "A form of hemolytic anemia with congenital onset." ; oboInOwl:hasAlternativeId "HP:0004811", "HP:0004824" ; oboInOwl:hasDbXref "MSH:D000745", "SNOMEDCT_US:38911009", "SNOMEDCT_US:42601008", "UMLS:C0002881", "UMLS:C4020827" ; oboInOwl:hasExactSynonym "Congenital haemolytic anaemia", "Congenital haemolytic anemia", "Congenital hemolytic anaemia" ; oboInOwl:hasRelatedSynonym "Neonatal hemolytic anaemia", "Neonatal hemolytic anemia" ; oboInOwl:id "HP:0004804" ; a owl:Class ; rdfs:label "Congenital hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004808 obo:IAO_0000115 "A form of leukemia characterized by overproduction of an early myeloid cell." ; oboInOwl:hasAlternativeId "HP:0001914", "HP:0004843", "HP:0005516", "HP:0006724", "HP:0006728" ; oboInOwl:hasDbXref "MSH:D015470", "SNOMEDCT_US:17788007", "SNOMEDCT_US:413443009", "SNOMEDCT_US:91861009", "UMLS:C0023467" ; oboInOwl:hasExactSynonym "AML", "Acute myeloblastic leukaemia", "Acute myeloblastic leukemia", "Acute myelocytic leukaemia", "Acute myelocytic leukemia", "Acute myelogenous leukaemia", "Acute myelogenous leukemia", "Acute myeloid leukaemia" ; oboInOwl:id "HP:0004808" ; a owl:Class ; rdfs:label "Acute myeloid leukemia" ; rdfs:subClassOf obo:HP_0002488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002488 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004809 obo:IAO_0000115 "Low platelet count associated with maternal platelet-specific alloantibodies." ; oboInOwl:hasDbXref "MSH:D054098", "SNOMEDCT_US:240305000", "UMLS:C3853779" ; oboInOwl:id "HP:0004809" ; a owl:Class ; rdfs:comment "Neonatal alloimmune thrombocytopenia occurs following fetomaternal transfusions leading to generation of alloreactive antiplatelet antibodies." ; rdfs:label "Neonatal alloimmune thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0004810 obo:IAO_0000115 "A type of hypoplastic anemia with congenital onset." ; oboInOwl:hasAlternativeId "HP:0005545" ; oboInOwl:hasDbXref "MSH:D000742", "MSH:D029503", "SNOMEDCT_US:234371002", "SNOMEDCT_US:52951008", "SNOMEDCT_US:88854002", "UMLS:C0002876", "UMLS:C1260899" ; oboInOwl:hasExactSynonym "Congenital dyserythropoietic anaemia", "Congenital dyserythropoietic anemia", "Congenital hypoplastic anaemia" ; oboInOwl:id "HP:0004810" ; a owl:Class ; rdfs:comment "In this condition, hematopoiesis must have been inadequate in fetal life. Affected infant have marked pallor and reticulocytopenia or absence of red blood cell precursors in an otherwise normally cellular bone marrow. This term does not refer to a particular diagnosis or etiology (or which several are known) but to the phenotypic feature." ; rdfs:label "Congenital hypoplastic anemia" ; rdfs:subClassOf obo:HP_0001908 . obo:HP_0004812 obo:IAO_0000115 "A type of ALL characterized by elevated levels of B-cell lymphoblasts in the bone marrow and the blood." ; oboInOwl:hasExactSynonym "B Acute Lymphoblastic Leukaemia", "Pre-B-cell acute lymphoblastic leukaemia", "Pre-B-cell acute lymphoblastic leukemia" ; oboInOwl:id "HP:0004812" ; a owl:Class ; rdfs:label "B Acute Lymphoblastic Leukemia" ; rdfs:subClassOf obo:HP_0006721 . obo:HP_0004813 obo:IAO_0000115 "Sudden onset of thrombocytopenia (reduced platelet count) within 5-10 days of the transfusion of blood products. The clinical presentation is post-transfusion purpura (PTP), wigth severe thrmbocytopenia, epistaxis, and hemorrhages." ; oboInOwl:hasDbXref "MSH:C562868", "SNOMEDCT_US:73162004", "UMLS:C0398648", "UMLS:C1868252" ; oboInOwl:hasRelatedSynonym "Post-transfusion purpura" ; oboInOwl:id "HP:0004813" ; a owl:Class ; rdfs:comment "Post-transfusion thrombocytopenia is thought to be related to platelet-specific alloantibody from prior transfusion/pregnancy." ; rdfs:label "Post-transfusion thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0004814 obo:IAO_0000115 "A kind of hemolytic anemia that is induced by the ingestion of fava beans." ; oboInOwl:hasDbXref "UMLS:C4021648" ; oboInOwl:hasExactSynonym "Fava bean-induced hemolytic anaemia", "Hemolytic anaemia following ingestion of fava beans", "Hemolytic anemia following ingestion of fava beans" ; oboInOwl:id "HP:0004814" ; a owl:Class ; rdfs:comment "Persons with glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to fava bean-induced hemolytic anemia because of the oxidative stress induced by compunds in Fava beans (thought to be vicine and isouramil). The same underlying defect can make affected persons susceptible to hemolysis induced by a number of mediciations." ; rdfs:label "Fava bean-induced hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004817 obo:IAO_0000115 "A form of hemolytic anemia that is triggered by ingestion of certain drugs." ; oboInOwl:hasDbXref "UMLS:C4025289" ; oboInOwl:hasExactSynonym "Drug-sensitive hemolytic anaemia" ; oboInOwl:id "HP:0004817" ; a owl:Class ; rdfs:label "Drug-sensitive hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004818 oboInOwl:hasDbXref "MSH:D006457", "SNOMEDCT_US:1963002", "UMLS:C0024790" ; oboInOwl:hasExactSynonym "Paroxysmal nocturnal haemoglobinuria" ; oboInOwl:id "HP:0004818" ; a owl:Class ; rdfs:label "Paroxysmal nocturnal hemoglobinuria" ; rdfs:subClassOf obo:HP_0003641 . obo:HP_0004819 obo:IAO_0000115 "A type of hypoplastic anemia in which the erythrocytes have a normal cell volume (the mean corpuscular volume is within normal limits)." ; oboInOwl:hasDbXref "UMLS:C1835875" ; oboInOwl:hasExactSynonym "Normocytic hypoplastic anaemia" ; oboInOwl:id "HP:0004819" ; a owl:Class ; rdfs:label "Normocytic hypoplastic anemia" ; rdfs:subClassOf obo:HP_0001908 . obo:HP_0004820 obo:IAO_0000115 "An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors." ; oboInOwl:hasDbXref "MSH:D015479", "SNOMEDCT_US:110005000", "SNOMEDCT_US:277601005", "SNOMEDCT_US:30962008", "UMLS:C0023479" ; oboInOwl:hasExactSynonym "Acute myelomonocytic leukaemia" ; oboInOwl:id "HP:0004820" ; a owl:Class ; rdfs:label "Acute myelomonocytic leukemia" ; rdfs:subClassOf obo:HP_0002488, obo:HP_0012324 . obo:HP_0004821 obo:IAO_0000115 "An excessive division of the lobes of the nucleus of a neutrophil." ; oboInOwl:hasDbXref "UMLS:C4025288" ; oboInOwl:hasExactSynonym "Hypermature neutrophils", "Hypersegmentation of neutrophil nuclei in peripheral blood" ; oboInOwl:id "HP:0004821" ; a owl:Class ; rdfs:comment "Neutrophils usually display 3-4 nuclear lobes. Hypersegmented neutrophile nuclei display 5 or more lobes. This feature can be seen in vitamin B12 or folate deficiency or with other etiologies." ; rdfs:label "Hypersegmentation of neutrophil nuclei" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0004822 oboInOwl:hasDbXref "MSH:C565598", "UMLS:C1857010" ; oboInOwl:id "HP:0004822" ; a owl:Class ; rdfs:label "Atypical elliptocytosis" ; rdfs:subClassOf obo:HP_0004445 . obo:HP_0004823 obo:IAO_0000115 "A type of poikilocytosis characterized by the presence in the blood of erythrocytes of varying sizes and abnormal shapes." ; oboInOwl:hasDbXref "UMLS:C2675920" ; oboInOwl:id "HP:0004823" ; a owl:Class ; rdfs:label "Anisopoikilocytosis" ; rdfs:subClassOf obo:HP_0004447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004825 obo:IAO_0000115 "An abnormal increase in the binding affinity of hemoglobin for oxygen." ; oboInOwl:hasDbXref "UMLS:C4021647" ; oboInOwl:hasExactSynonym "Increased Hb O2 affinity", "Increased Hb oxygen affinity", "Increased haemoglobin O2 affinity", "Increased haemoglobin oxygen affinity", "Increased hemoglobin O2 affinity" ; oboInOwl:id "HP:0004825" ; a owl:Class ; rdfs:label "Increased hemoglobin oxygen affinity" ; rdfs:subClassOf obo:HP_0020054 . obo:HP_0004826 obo:IAO_0000115 "A type of megaloblastic anemia that does not improve upon administration of folate. Since vitamin B12 acts by promoting recycling of folate, administration of vitamin B12 also does not improve this type of anemia." ; oboInOwl:hasDbXref "UMLS:C4025287" ; oboInOwl:hasExactSynonym "Folate-unresponsive megaloblastic anaemia" ; oboInOwl:id "HP:0004826" ; a owl:Class ; rdfs:label "Folate-unresponsive megaloblastic anemia" ; rdfs:subClassOf obo:HP_0001889 . obo:HP_0004828 obo:IAO_0000115 "A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts." ; oboInOwl:hasDbXref "ICD-O:M9982/3", "SNOMEDCT_US:109998009", "SNOMEDCT_US:128846006", "UMLS:C1264195" ; oboInOwl:hasExactSynonym "Myelodysplasia with sideroblastosis", "Refractory anaemia with ringed sideroblasts" ; oboInOwl:id "HP:0004828" ; a owl:Class ; rdfs:label "Refractory anemia with ringed sideroblasts" ; rdfs:subClassOf obo:HP_0012150 . obo:HP_0004831 obo:IAO_0000115 "Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream." ; oboInOwl:hasDbXref "UMLS:C0749398", "UMLS:C4025286" ; oboInOwl:hasRelatedSynonym "Recurrent thromboembolic disease" ; oboInOwl:id "HP:0004831" ; a owl:Class ; rdfs:label "Recurrent thromboembolism" ; rdfs:subClassOf obo:HP_0001907 . obo:HP_0004835 obo:IAO_0000115 "The presence of erythrocytes that are sphere-shaped and reduced in size." ; oboInOwl:hasDbXref "UMLS:C4025285" ; oboInOwl:id "HP:0004835" ; a owl:Class ; rdfs:label "Microspherocytosis" ; rdfs:subClassOf obo:HP_0004444 . obo:HP_0004836 obo:IAO_0000115 "A type of acute myeloid leukemia in which abnormal promyelocytes predominate." ; oboInOwl:hasDbXref "MSH:D015473", "SNOMEDCT_US:110004001", "SNOMEDCT_US:28950004", "UMLS:C0023487" ; oboInOwl:hasExactSynonym "Acute promyelocytic leukaemia" ; oboInOwl:id "HP:0004836" ; a owl:Class ; rdfs:label "Acute promyelocytic leukemia" ; rdfs:subClassOf obo:HP_0002488 . obo:HP_0004839 obo:IAO_0000115 "A form of severe hemolytic anemia characterized by erythrocyte morphology reminiscent of that seen in patients after a thermal burn." ; oboInOwl:hasAlternativeId "HP:0004805" ; oboInOwl:hasDbXref "MSH:C563004", "SNOMEDCT_US:9434008", "UMLS:C0520739" ; oboInOwl:hasExactSynonym "hereditary pyropoikilocytosis" ; oboInOwl:id "HP:0004839" ; a owl:Class ; rdfs:label "Pyropoikilocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0004840 obo:IAO_0000115 "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes." ; oboInOwl:hasAlternativeId "HP:0004842" ; oboInOwl:hasDbXref "MSH:C536357", "SNOMEDCT_US:44666001", "UMLS:C0271901" ; oboInOwl:hasExactSynonym "Hypochromic microcytic anaemia", "Hypochromic, microcytic anaemia", "Hypochromic, microcytic anemia" ; oboInOwl:id "HP:0004840" ; a owl:Class ; rdfs:label "Hypochromic microcytic anemia" ; rdfs:subClassOf obo:HP_0001931, obo:HP_0001935 . obo:HP_0004841 obo:IAO_0000115 "Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade." ; oboInOwl:hasAlternativeId "HP:0005514", "HP:0005551", "HP:0008286" ; oboInOwl:hasDbXref "MSH:D005175", "SNOMEDCT_US:46981006", "UMLS:C0015526" ; oboInOwl:hasExactSynonym "Factor XII deficiency", "Hageman factor deficiency" ; oboInOwl:id "HP:0004841" ; a owl:Class ; rdfs:label "Reduced factor XII activity" ; rdfs:subClassOf obo:HP_0010989 . obo:HP_0004844 obo:IAO_0000115 "A type of hemolytic anemia in which the Coombs test is positive." ; oboInOwl:hasAlternativeId "HP:0003539" ; oboInOwl:hasDbXref "SNOMEDCT_US:74789008", "UMLS:C0520736" ; oboInOwl:hasExactSynonym "Coombs-positive hemolytic anaemia", "Direct Coombs positive" ; oboInOwl:id "HP:0004844" ; a owl:Class ; rdfs:comment "The Coombs test measures a coating of immunoglobulin or complement on the red cell surface." ; rdfs:label "Coombs-positive hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004845 obo:IAO_0000115 "The accumulation of transformed primitive hematopoietic blast cells, which lose their ability of normal differentiation and proliferation." ; oboInOwl:hasAlternativeId "HP:0004833" ; oboInOwl:hasDbXref "MSH:D007948", "SNOMEDCT_US:22331004", "SNOMEDCT_US:413441006", "UMLS:C0023465" ; oboInOwl:hasExactSynonym "AML-M5", "AMoL", "Acute monoblastic leukaemia", "Acute monoblastic leukemia", "Acute monocytic leukaemia" ; oboInOwl:id "HP:0004845" ; a owl:Class ; rdfs:label "Acute monocytic leukemia" ; rdfs:subClassOf obo:HP_0002488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004846 obo:IAO_0000115 "Bleeding that persists longer than the normal time following a surgical procedure." ; oboInOwl:hasDbXref "UMLS:C4021646" ; oboInOwl:hasExactSynonym "Excessive bleeding during surgery", "Prolonged bleeding after surgery", "Protracted bleeding after surgery" ; oboInOwl:id "HP:0004846" ; a owl:Class ; rdfs:label "Prolonged bleeding after surgery" ; rdfs:subClassOf obo:HP_0011890 . obo:HP_0004848 obo:IAO_0000115 "A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity." ; oboInOwl:hasDbXref "SNOMEDCT_US:425688002", "SNOMEDCT_US:426955004", "UMLS:C1960397" ; oboInOwl:hasExactSynonym "Ph-positive acute lymphoblastic leukaemia", "Philadelphia-positive acute lymphoblastic leukaemia", "Philadelphia-positive acute lymphoblastic leukemia" ; oboInOwl:id "HP:0004848" ; a owl:Class ; rdfs:label "Ph-positive acute lymphoblastic leukemia" ; rdfs:subClassOf obo:HP_0006721 . obo:HP_0004850 obo:IAO_0000115 "Repeated episodes of the formation of a blot clot in a deep vein." ; oboInOwl:hasDbXref "SNOMEDCT_US:710167004", "UMLS:C1735901" ; oboInOwl:hasExactSynonym "Recurrent deep vein blood clot", "Recurrent venous thrombosis" ; oboInOwl:id "HP:0004850" ; a owl:Class ; rdfs:label "Recurrent deep vein thrombosis" ; rdfs:subClassOf obo:HP_0002625 . obo:HP_0004851 obo:IAO_0000115 "A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of folate." ; oboInOwl:hasDbXref "UMLS:C2749656" ; oboInOwl:hasExactSynonym "Folate-responsive megaloblastic anaemia" ; oboInOwl:id "HP:0004851" ; a owl:Class ; rdfs:label "Folate-responsive megaloblastic anemia" ; rdfs:subClassOf obo:HP_0001889 . obo:HP_0004852 obo:IAO_0000115 "Decreased alkaline phosphatase measured within leukocytes." ; oboInOwl:hasDbXref "UMLS:C1850780" ; oboInOwl:hasExactSynonym "Low leukocyte alkaline phosphatase", "Reduced leukocyte ALP" ; oboInOwl:id "HP:0004852" ; a owl:Class ; rdfs:label "Reduced leukocyte alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004854 obo:IAO_0000115 "Reduced platelet count that occurs sporadically, i.e., it comes and goes." ; oboInOwl:hasDbXref "UMLS:C1839167" ; oboInOwl:id "HP:0004854" ; a owl:Class ; rdfs:label "Intermittent thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0004855 obo:IAO_0000115 "An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein S. Protein S is a cofactor of protein C." ; oboInOwl:hasDbXref "MSH:D018455", "SNOMEDCT_US:1563006", "UMLS:C0242666", "UMLS:C4025284" ; oboInOwl:hasNarrowSynonym "Protein S deficiency" ; oboInOwl:id "HP:0004855" ; a owl:Class ; rdfs:comment "Protein S functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa in the coagulation pathway. Therefore, a defect in protein S is associated with an increased risk of thrombosis." ; rdfs:label "Reduced protein S activity" ; rdfs:subClassOf obo:HP_0030780 . obo:HP_0004856 obo:IAO_0000115 "A type of anemia characterized by an normal concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes." ; oboInOwl:hasDbXref "SNOMEDCT_US:4984008", "UMLS:C0271902" ; oboInOwl:hasExactSynonym "Normochromic microcytic anaemia" ; oboInOwl:id "HP:0004856" ; a owl:Class ; rdfs:label "Normochromic microcytic anemia" ; rdfs:subClassOf obo:HP_0001935 . obo:HP_0004857 obo:IAO_0000115 "A type of anemia characterized by abnormally large erythrocytes with abnormally high amounts of haemoglobin." ; oboInOwl:hasDbXref "UMLS:C3854594" ; oboInOwl:hasExactSynonym "Hyperchromic macrocytic anaemia" ; oboInOwl:id "HP:0004857" ; a owl:Class ; rdfs:label "Hyperchromic macrocytic anemia" ; rdfs:subClassOf obo:HP_0001972 . obo:HP_0004859 obo:IAO_0000115 "Thrombocytopenia related to lack of or severe reduction in the count of megakaryocytes." ; oboInOwl:hasDbXref "SNOMEDCT_US:234482009", "UMLS:C0398639" ; oboInOwl:id "HP:0004859" ; a owl:Class ; rdfs:label "Amegakaryocytic thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0004860 obo:IAO_0000115 "A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of thiamine." ; oboInOwl:hasDbXref "SNOMEDCT_US:12907000", "UMLS:C0271972" ; oboInOwl:hasExactSynonym "Thiamine-responsive megaloblastic anaemia" ; oboInOwl:id "HP:0004860" ; a owl:Class ; rdfs:label "Thiamine-responsive megaloblastic anemia" ; rdfs:subClassOf obo:HP_0001889 . obo:HP_0004861 oboInOwl:hasDbXref "UMLS:C2675059" ; oboInOwl:hasExactSynonym "Refractory macrocytic anaemia" ; oboInOwl:id "HP:0004861" ; a owl:Class ; rdfs:label "Refractory macrocytic anemia" ; rdfs:subClassOf obo:HP_0001972 . obo:HP_0004863 oboInOwl:hasDbXref "UMLS:C4025283" ; oboInOwl:hasExactSynonym "Compensated hemolytic anaemia" ; oboInOwl:id "HP:0004863" ; a owl:Class ; rdfs:label "Compensated hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0004864 obo:IAO_0000115 "A type of sideroblastic anemia that is not responsive to treatment." ; oboInOwl:hasDbXref "MSH:D000756", "SNOMEDCT_US:41841004", "UMLS:C0002896" ; oboInOwl:hasExactSynonym "Refractory sideroblastic anaemia" ; oboInOwl:id "HP:0004864" ; a owl:Class ; rdfs:label "Refractory sideroblastic anemia" ; rdfs:subClassOf obo:HP_0001924 . obo:HP_0004866 obo:IAO_0000115 "Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP." ; oboInOwl:hasDbXref "UMLS:C4025282" ; oboInOwl:id "HP:0004866" ; a owl:Class ; rdfs:label "Impaired ADP-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0004870 obo:IAO_0000115 "An chronic form of hemolytic anemia." ; oboInOwl:hasAlternativeId "HP:0004815" ; oboInOwl:hasDbXref "SNOMEDCT_US:707480001", "UMLS:C1387532" ; oboInOwl:hasExactSynonym "Chronic hemolytic anaemia", "hemolytic anemia, chronic" ; oboInOwl:id "HP:0004870" ; a owl:Class ; rdfs:label "Chronic hemolytic anemia" ; rdfs:subClassOf obo:HP_0001878 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001878 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0004871 obo:IAO_0000115 "The presence of a fistula between the bowel and the perineum." ; oboInOwl:hasDbXref "SNOMEDCT_US:284077005", "UMLS:C0561921" ; oboInOwl:id "HP:0004871" ; a owl:Class ; rdfs:comment "The perineum is the diamond-shaped region of the body between the pubic arch and the anus." ; rdfs:label "Perineal fistula" ; rdfs:subClassOf obo:HP_0100589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002356 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004872 obo:IAO_0000115 "An abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound." ; oboInOwl:hasDbXref "MSH:D000069290", "SNOMEDCT_US:236037000", "SNOMEDCT_US:241556001", "UMLS:C0267716", "UMLS:C4021645" ; oboInOwl:hasExactSynonym "Recurrent abdominal hernia" ; oboInOwl:id "HP:0004872" ; a owl:Class ; rdfs:label "Incisional hernia" ; rdfs:subClassOf obo:HP_0004299 . obo:HP_0004875 oboInOwl:hasDbXref "UMLS:C4025281" ; oboInOwl:id "HP:0004875" ; a owl:Class ; rdfs:label "Neonatal inspiratory stridor" ; rdfs:subClassOf obo:HP_0002643, obo:HP_0005348 . obo:HP_0004876 obo:IAO_0000115 "Pneumothorax occurring neonatally without traumatic injury to the chest or lung." ; oboInOwl:hasDbXref "UMLS:C1857021" ; oboInOwl:hasExactSynonym "Neonatal pneumothorax" ; oboInOwl:id "HP:0004876" ; a owl:Class ; rdfs:label "Spontaneous neonatal pneumothorax" ; rdfs:subClassOf obo:HP_0002108 . obo:HP_0004878 obo:IAO_0000115 "Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall." ; oboInOwl:hasDbXref "UMLS:C0240017" ; oboInOwl:hasExactSynonym "Muscle weakness between ribs" ; oboInOwl:hasRelatedSynonym "Dependence on diaphragmatic breathing" ; oboInOwl:id "HP:0004878" ; a owl:Class ; rdfs:label "Intercostal muscle weakness" ; rdfs:subClassOf obo:HP_0000765, obo:HP_0001324, obo:HP_0002093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001111 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004879 obo:IAO_0000115 "Episodic hyperventilation." ; oboInOwl:hasDbXref "SNOMEDCT_US:423427003", "UMLS:C1828017" ; oboInOwl:hasExactSynonym "Episodic hyperventilation", "Intermittent overbreathing" ; oboInOwl:id "HP:0004879" ; a owl:Class ; rdfs:label "Intermittent hyperventilation" ; rdfs:subClassOf obo:HP_0002883 . obo:HP_0004880 obo:IAO_0000115 "Increased susceptibility to respiratory infections in early life, as manifested by recurrent episodes of respiratory infections." ; oboInOwl:hasDbXref "UMLS:C4025280" ; oboInOwl:id "HP:0004880" ; a owl:Class ; rdfs:label "Respiratory infections in early life" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0004881 oboInOwl:hasDbXref "UMLS:C1844946" ; oboInOwl:hasExactSynonym "Episodic slow breathing", "Episodic under breathing" ; oboInOwl:id "HP:0004881" ; a owl:Class ; rdfs:label "Episodic hypoventilation" ; rdfs:subClassOf obo:HP_0002791 . obo:HP_0004885 oboInOwl:hasDbXref "UMLS:C1844945" ; oboInOwl:hasExactSynonym "Episodic difficulty breathing", "respiratory distress, episodic" ; oboInOwl:id "HP:0004885" ; a owl:Class ; rdfs:label "Episodic respiratory distress" ; rdfs:subClassOf obo:HP_0002098 . obo:HP_0004886 oboInOwl:hasDbXref "SNOMEDCT_US:55490007", "UMLS:C0265763" ; oboInOwl:id "HP:0004886" ; a owl:Class ; rdfs:label "Congenital laryngeal stridor" ; rdfs:subClassOf obo:HP_0005348 . obo:HP_0004887 obo:IAO_0000115 "A state of respiratory distress that requires a life saving intervention in the form of gaining airway access and instituting positive pressure ventilation." ; oboInOwl:hasAlternativeId "HP:0004883" ; oboInOwl:hasDbXref "UMLS:C4025279" ; oboInOwl:hasExactSynonym "Respiratory distress necessitating mechanical ventilation", "Respiratory distress requiring endotracheal intubation", "Respiratory distress requiring mechanical ventilation" ; oboInOwl:id "HP:0004887" ; a owl:Class ; rdfs:label "Respiratory failure requiring assisted ventilation" ; rdfs:subClassOf obo:HP_0002093 . obo:HP_0004889 oboInOwl:hasDbXref "UMLS:C3807025" ; oboInOwl:id "HP:0004889" ; a owl:Class ; rdfs:label "Intermittent episodes of respiratory insufficiency due to muscle weakness" ; rdfs:subClassOf obo:HP_0002747 . obo:HP_0004890 obo:IAO_0000115 "An abnormally elevated blood pressure in the circulation of the pulmonary artery." ; oboInOwl:hasAlternativeId "HP:0004958" ; oboInOwl:hasDbXref "UMLS:C3805917" ; oboInOwl:hasExactSynonym "Elevated lung artery pressure", "increased pulmonary artery pressure" ; oboInOwl:id "HP:0004890" ; a owl:Class ; rdfs:label "Elevated pulmonary artery pressure" ; rdfs:subClassOf obo:HP_0030875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001576 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004891 obo:IAO_0000115 "Increased susceptibility to infections due to aspiration, as manifested by recurrent episodes of infections due to aspiration." ; oboInOwl:hasDbXref "UMLS:C3806285" ; oboInOwl:id "HP:0004891" ; a owl:Class ; rdfs:label "Recurrent infections due to aspiration" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0004894 oboInOwl:hasDbXref "UMLS:C3806280" ; oboInOwl:id "HP:0004894" ; a owl:Class ; rdfs:label "Laryngotracheal stenosis" ; rdfs:subClassOf obo:HP_0001602, obo:HP_0002777 . obo:HP_0004897 obo:IAO_0000115 "A form of lactic acidemia that occurs in relation to stress or infection." ; oboInOwl:hasDbXref "UMLS:C4025278" ; oboInOwl:hasRelatedSynonym "Metabolic crises during febrile infections" ; oboInOwl:id "HP:0004897" ; a owl:Class ; rdfs:label "Stress/infection-induced lactic acidosis" ; rdfs:subClassOf obo:HP_0003128 . obo:HP_0004898 obo:IAO_0000115 "A continuous form of lactic acidemia." ; oboInOwl:hasDbXref "UMLS:C3554538" ; oboInOwl:id "HP:0004898" ; a owl:Class ; rdfs:label "Persistent lactic acidosis" ; rdfs:subClassOf obo:HP_0003128 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003128 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000689 ] ) ] ] . obo:HP_0004900 obo:IAO_0000115 "A severe form of lactic acidemia." ; oboInOwl:hasDbXref "UMLS:C1839436" ; oboInOwl:id "HP:0004900" ; a owl:Class ; rdfs:label "Severe lactic acidosis" ; rdfs:subClassOf obo:HP_0003128 . obo:HP_0004901 obo:IAO_0000115 "A form of lactic acidemia that occurs following exercise or exertion." ; oboInOwl:hasDbXref "UMLS:C4025277" ; oboInOwl:hasExactSynonym "Exercise-induced lactic acidosis" ; oboInOwl:id "HP:0004901" ; a owl:Class ; rdfs:label "Exercise-induced lactic acidemia" ; rdfs:subClassOf obo:HP_0003128 . obo:HP_0004902 obo:IAO_0000115 "A form of lactic acidemia with congenital onset." ; oboInOwl:hasDbXref "UMLS:C4025276" ; oboInOwl:id "HP:0004902" ; a owl:Class ; rdfs:label "Congenital lactic acidosis" ; rdfs:subClassOf obo:HP_0003128 . obo:HP_0004904 obo:IAO_0000115 "The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistence, and lack of evidence of autoimmune destruction of the beta cells." ; oboInOwl:hasDbXref "MSH:C562772", "SNOMEDCT_US:609561005", "UMLS:C0342276" ; oboInOwl:hasExactSynonym "Maturity onset diabetes of the young" ; oboInOwl:hasRelatedSynonym "MODY" ; oboInOwl:id "HP:0004904" ; a owl:Class ; rdfs:label "Maturity-onset diabetes of the young" ; rdfs:subClassOf obo:HP_0000819 . obo:HP_0004905 obo:IAO_0000115 "A reduced concentration of vitamin A." ; oboInOwl:hasDbXref "MSH:D014802", "SNOMEDCT_US:72000004", "UMLS:C0042842" ; oboInOwl:hasExactSynonym "Vitamin A deficiency" ; oboInOwl:id "HP:0004905" ; a owl:Class ; rdfs:label "Low levels of vitamin A" ; rdfs:subClassOf obo:HP_0008372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_12777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004906 oboInOwl:hasDbXref "SNOMEDCT_US:427784006", "UMLS:C1850544" ; oboInOwl:id "HP:0004906" ; a owl:Class ; rdfs:label "Hypernatremic dehydration" ; rdfs:subClassOf obo:HP_0001986 . obo:HP_0004909 oboInOwl:hasDbXref "UMLS:C0740896" ; oboInOwl:id "HP:0004909" ; a owl:Class ; rdfs:label "Hypokalemic hypochloremic metabolic alkalosis" ; rdfs:subClassOf obo:HP_0001960, obo:HP_0005977 . obo:HP_0004910 oboInOwl:hasDbXref "UMLS:C1858626" ; oboInOwl:hasExactSynonym "HCO3-wasting renal tubular acidosis", "Renal bicarbonate wasting" ; oboInOwl:id "HP:0004910" ; a owl:Class ; rdfs:label "Bicarbonate-wasting renal tubular acidosis" ; rdfs:subClassOf obo:HP_0001947 . obo:HP_0004911 obo:IAO_0000115 "Repeated transient episodes of metabolic acidosis, that is, of the buildup of acid or depletion of base due to accumulation of metabolic acids." ; oboInOwl:hasAlternativeId "HP:0005963" ; oboInOwl:hasDbXref "UMLS:C1859516" ; oboInOwl:hasExactSynonym "Recurrent episodes of acidosis" ; oboInOwl:id "HP:0004911" ; a owl:Class ; rdfs:label "Episodic metabolic acidosis" ; rdfs:subClassOf obo:HP_0001942 . obo:HP_0004912 oboInOwl:hasDbXref "MSH:D063730", "SNOMEDCT_US:66266003", "UMLS:C1704375" ; oboInOwl:id "HP:0004912" ; a owl:Class ; rdfs:label "Hypophosphatemic rickets" ; rdfs:subClassOf obo:HP_0002148, obo:HP_0002748 . obo:HP_0004913 obo:IAO_0000115 "An intermittent (discontinuous) form of lactic acidemia." ; oboInOwl:hasDbXref "UMLS:C1844917" ; oboInOwl:id "HP:0004913" ; a owl:Class ; rdfs:label "Intermittent lactic acidemia" ; rdfs:subClassOf obo:HP_0003128 . obo:HP_0004914 obo:IAO_0000115 "Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period." ; oboInOwl:hasAlternativeId "HP:0004917" ; oboInOwl:hasDbXref "UMLS:C4021644" ; oboInOwl:hasExactSynonym "Episodic infantile hypoglycemia", "Recurrent low blood sugar in infant" ; oboInOwl:id "HP:0004914" ; a owl:Class ; rdfs:label "Recurrent infantile hypoglycemia" ; rdfs:subClassOf obo:HP_0001988 . obo:HP_0004915 obo:IAO_0000115 "An impairment of galactose metabolism." ; oboInOwl:hasDbXref "UMLS:C4021643" ; oboInOwl:hasExactSynonym "Impaired galactose metabolism" ; oboInOwl:id "HP:0004915" ; a owl:Class ; rdfs:label "Impairment of galactose metabolism" ; rdfs:subClassOf obo:HP_0032245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004916 oboInOwl:hasDbXref "UMLS:C4025275" ; oboInOwl:hasExactSynonym "Generalised distal tubular acidosis" ; oboInOwl:id "HP:0004916" ; a owl:Class ; rdfs:label "Generalized distal tubular acidosis" ; rdfs:subClassOf obo:HP_0008341 . obo:HP_0004918 obo:IAO_0000115 "A form of metabolic acidosis with increased serum chloride levels." ; oboInOwl:hasDbXref "UMLS:C1969073" ; oboInOwl:hasExactSynonym "Non-gap acidosis" ; oboInOwl:id "HP:0004918" ; a owl:Class ; rdfs:label "Hyperchloremic metabolic acidosis" ; rdfs:subClassOf obo:HP_0001942, obo:HP_0001995 . obo:HP_0004919 oboInOwl:hasDbXref "MSH:D005693", "SNOMEDCT_US:190745006", "SNOMEDCT_US:190749000", "UMLS:C0016952" ; oboInOwl:id "HP:0004919" ; a owl:Class ; rdfs:label "Galactose intolerance" ; rdfs:subClassOf obo:HP_0004915 . obo:HP_0004920 oboInOwl:hasDbXref "UMLS:C1849926" ; oboInOwl:id "HP:0004920" ; a owl:Class ; rdfs:label "Phenylpyruvic acidemia" ; rdfs:subClassOf obo:HP_0032368 . obo:HP_0004921 obo:IAO_0000115 "An abnormality of magnesium ion homeostasis." ; oboInOwl:hasAlternativeId "HP:0008274" ; oboInOwl:hasDbXref "UMLS:C4020826", "UMLS:C4025274" ; oboInOwl:hasExactSynonym "Abnormal Mg concentration", "Abnormality of magnesium homeostasis" ; oboInOwl:hasRelatedSynonym "Abnormal magnesium metabolism" ; oboInOwl:id "HP:0004921" ; a owl:Class ; rdfs:label "Abnormal magnesium concentration" ; rdfs:subClassOf obo:HP_0010927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0010960 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004922 oboInOwl:hasDbXref "UMLS:C4025273" ; oboInOwl:id "HP:0004922" ; a owl:Class ; rdfs:label "Atypical hyperphenylalaninemia" ; rdfs:subClassOf obo:HP_0010893 . obo:HP_0004923 obo:IAO_0000115 "An increased concentration of L-phenylalanine in the blood." ; oboInOwl:hasDbXref "MSH:D010661", "SNOMEDCT_US:68528007", "UMLS:C0751435" ; oboInOwl:id "HP:0004923" ; a owl:Class ; rdfs:label "Hyperphenylalaninemia" ; rdfs:subClassOf obo:HP_0010893 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004924 obo:IAO_0000115 "An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral administration of glucose." ; oboInOwl:hasDbXref "UMLS:C1847425" ; oboInOwl:hasExactSynonym "Abnormal glucose oral tolerance test" ; oboInOwl:id "HP:0004924" ; a owl:Class ; rdfs:label "Abnormal oral glucose tolerance" ; rdfs:subClassOf obo:HP_0040270 . obo:HP_0004925 obo:IAO_0000115 "A chronic form of lactic acidemia." ; oboInOwl:hasAlternativeId "HP:0004899" ; oboInOwl:hasDbXref "UMLS:C1839437" ; oboInOwl:id "HP:0004925" ; a owl:Class ; rdfs:label "Chronic lactic acidosis" ; rdfs:subClassOf obo:HP_0003128, obo:HP_0012468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_28358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0004926 oboInOwl:hasDbXref "UMLS:C1868528" ; oboInOwl:id "HP:0004926" ; a owl:Class ; rdfs:label "Orthostatic hypotension due to autonomic dysfunction" ; rdfs:subClassOf obo:HP_0001278 . obo:HP_0004927 obo:IAO_0000115 "An abnormal widening of the diameter of the pulmonary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:251047005", "UMLS:C0428851" ; oboInOwl:id "HP:0004927" ; a owl:Class ; rdfs:label "Pulmonary artery dilatation" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0004928 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0004928" ; a owl:Class ; rdfs:label "obsolete Peripheral arterial stenosis" ; owl:deprecated true . obo:HP_0004929 obo:IAO_0100001 "HP:0001677" ; oboInOwl:id "HP:0004929" ; a owl:Class ; rdfs:label "obsolete Coronary atherosclerosis" ; owl:deprecated true . obo:HP_0004930 dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:07:00Z" ; oboInOwl:hasDbXref "UMLS:C4025271" ; oboInOwl:hasExactSynonym "Abnormality of the lung blood vessels" ; oboInOwl:id "HP:0004930" ; a owl:Class ; rdfs:label "Abnormality of the pulmonary vasculature" ; rdfs:subClassOf obo:HP_0002088, obo:HP_0002597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000102 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004931 obo:IAO_0000115 "Arteriosclerosis (increased thickness, increased stiffness, loss of elasticity) of the small arteries of the brain." ; oboInOwl:hasBroadSynonym "Hardened artery wall in small cerebral arteries" ; oboInOwl:hasDbXref "UMLS:C4025270", "UMLS:C4280505" ; oboInOwl:id "HP:0004931" ; a owl:Class ; rdfs:label "Arteriosclerosis of small cerebral arteries" ; rdfs:subClassOf obo:HP_0002634, obo:HP_0009145 . obo:HP_0004933 obo:IAO_0000115 "A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space." ; oboInOwl:hasDbXref "UMLS:C1836653" ; oboInOwl:hasExactSynonym "Type A aortic dissection" ; oboInOwl:id "HP:0004933" ; a owl:Class ; rdfs:comment "According to the Stanford classification, type A aortic dissection affects the ascending aorta and arch." ; rdfs:label "Ascending aortic dissection" ; rdfs:subClassOf obo:HP_0002647, obo:HP_0031784 . obo:HP_0004934 obo:IAO_0000115 "Abnormal calcification of the vasculature." ; oboInOwl:hasDbXref "MSH:D061205", "SNOMEDCT_US:237897009", "UMLS:C0342649" ; oboInOwl:id "HP:0004934" ; a owl:Class ; rdfs:label "Vascular calcification" ; rdfs:subClassOf obo:HP_0011915, obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002049 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004935 obo:IAO_0000115 "A congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:10930001", "SNOMEDCT_US:204443008", "UMLS:C0265908" ; oboInOwl:hasExactSynonym "Pulmonary atresia" ; oboInOwl:id "HP:0004935" ; a owl:Class ; rdfs:comment "Pulmonary artery atresia means that unoxygenated blood in the right ventricle can not be effectively pumped into the lung for oxygenation." ; rdfs:label "Pulmonary artery atresia" ; rdfs:subClassOf obo:HP_0030966 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004936 obo:IAO_0000115 "Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow." ; oboInOwl:hasDbXref "MSH:D020246", "SNOMEDCT_US:111293003", "UMLS:C0042487" ; oboInOwl:hasExactSynonym "Blood clot in vein" ; oboInOwl:id "HP:0004936" ; a owl:Class ; rdfs:label "Venous thrombosis" ; rdfs:subClassOf obo:HP_0001977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004937 obo:IAO_0000115 "An aneurysm (severe localized balloon-like outward bulging) in the pulmonary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:194892009", "UMLS:C0155676" ; oboInOwl:id "HP:0004937" ; a owl:Class ; rdfs:label "Pulmonary artery aneurysm" ; rdfs:subClassOf obo:HP_0004927 . obo:HP_0004938 obo:IAO_0000115 "Excessive bending, twisting, and winding of a cerebral artery." ; oboInOwl:hasDbXref "UMLS:C1836791" ; oboInOwl:hasExactSynonym "Twisted cerebral arteries" ; oboInOwl:id "HP:0004938" ; a owl:Class ; rdfs:label "Tortuous cerebral arteries" ; rdfs:subClassOf obo:HP_0005116, obo:HP_0009145 . obo:HP_0004940 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts, affecting arteries distributed throughout the body." ; oboInOwl:hasAlternativeId "HP:0004967" ; oboInOwl:hasDbXref "UMLS:C4025269" ; oboInOwl:hasExactSynonym "Generalised arterial calcification" ; oboInOwl:id "HP:0004940" ; a owl:Class ; rdfs:label "Generalized arterial calcification" ; rdfs:subClassOf obo:HP_0003207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004572 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004941 obo:IAO_0000115 "Increased pressure in the pre-hepatic portal vein." ; oboInOwl:hasDbXref "UMLS:C4025268" ; oboInOwl:id "HP:0004941" ; a owl:Class ; rdfs:comment """Hypertension in the portal venous tree proper. previous def: 'has part' some ('increased pressure' and ('inheres in' some ('arterial blood' and ('part of' some 'Pre-hepatic portal vein (adult human)'))) and ('has modifier' some abnormal))""" ; rdfs:label "Extrahepatic portal hypertension" ; rdfs:subClassOf obo:HP_0001409 . obo:HP_0004942 obo:IAO_0000115 "Aortic dilatation refers to a dimension that is greater than the 95th percentile for the normal person age, sex and body size. In contrast, an aneurysm is defined as a localized dilation of the aorta that is more than 150 percent of predicted (ratio of observed to expected diameter 1.5 or more). Aneurysm should be distinguished from ectasia, which represents a diffuse dilation of the aorta less than 50 percent of normal aorta diameter." ; oboInOwl:hasAlternativeId "HP:0001724" ; oboInOwl:hasDbXref "Fyler:2301", "Fyler:2708", "MSH:D001014", "SNOMEDCT_US:67362008", "UMLS:C0003486" ; oboInOwl:hasExactSynonym "Aortic dilatation", "Bulge in wall of large artery that carries blood away from heart" ; oboInOwl:id "HP:0004942" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe (pathological) form of dilatation of a segment of a blood vessel. In clinical practice, dilatation and aneurysm are occasionally used interchangably. In this subhierarchy, we therefore use aneurysm as the primary label and list dilatation as a broad synonym." ; rdfs:label "Aortic aneurysm" ; rdfs:subClassOf obo:HP_0001679, obo:HP_0002617 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] ] ) ] ] . obo:HP_0004943 obo:IAO_0000115 "Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors." ; oboInOwl:hasBroadSynonym "Accelerated plaque build-up in arteries" ; oboInOwl:hasDbXref "UMLS:C1849618", "UMLS:C4280504" ; oboInOwl:id "HP:0004943" ; a owl:Class ; rdfs:label "Accelerated atherosclerosis" ; rdfs:subClassOf obo:HP_0002621 . obo:HP_0004944 obo:IAO_0000115 "The presence of a localized dilatation or ballooning of a cerebral artery." ; oboInOwl:hasAlternativeId "HP:0002618", "HP:0006816" ; oboInOwl:hasBroadSynonym "Brain aneurysm", "Intracranial aneurysm" ; oboInOwl:hasDbXref "MSH:D002532", "SNOMEDCT_US:128608001", "UMLS:C0751003", "UMLS:C1290398" ; oboInOwl:hasNarrowSynonym "Cerebral aneurysm", "Cerebral artery aneurysm" ; oboInOwl:id "HP:0004944" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of the cerebral artery" ; rdfs:subClassOf obo:HP_0002617, obo:HP_0009145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004945 obo:IAO_0000115 "A separation (dissection) of the layers of the extracranial portion of the internal carotid artery wall." ; oboInOwl:hasDbXref "UMLS:C4025267" ; oboInOwl:id "HP:0004945" ; a owl:Class ; rdfs:label "Extracranial internal carotid artery dissection" ; rdfs:subClassOf obo:HP_0005294, obo:HP_0012159 . obo:HP_0004947 obo:IAO_0000115 "An abnormal connection between an artery and vein." ; oboInOwl:hasAlternativeId "HP:0004946" ; oboInOwl:hasDbXref "MSH:D001164", "SNOMEDCT_US:128617001", "SNOMEDCT_US:439470001", "UMLS:C0003855" ; oboInOwl:hasExactSynonym "Arteriovenous fistulas" ; oboInOwl:id "HP:0004947" ; a owl:Class ; rdfs:label "Arteriovenous fistula" ; rdfs:subClassOf obo:HP_0100026 . obo:HP_0004948 obo:IAO_0000115 "Abnormal twisting of arteries or veins." ; oboInOwl:hasDbXref "UMLS:C2673776" ; oboInOwl:hasExactSynonym "Twisted blood vessels" ; oboInOwl:id "HP:0004948" ; a owl:Class ; rdfs:label "Vascular tortuosity" ; rdfs:subClassOf obo:HP_0033353 . obo:HP_0004950 obo:IAO_0000115 "Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication." ; oboInOwl:hasAlternativeId "HP:0004928", "HP:0004973", "HP:0005296", "HP:0005299", "HP:0005309", "HP:0005315", "HP:0005794" ; oboInOwl:hasDbXref "MSH:D016491", "MSH:D058729", "SNOMEDCT_US:399957001", "SNOMEDCT_US:400047006", "UMLS:C0085096", "UMLS:C1704436" ; oboInOwl:hasExactSynonym "Peripheral artery disease" ; oboInOwl:hasRelatedSynonym "Arterial disease of legs", "Occlusive arterial disease", "Occlusive vascular disease", "Peripheral artery occlusive disease", "Peripheral vascular disease" ; oboInOwl:id "HP:0004950" ; a owl:Class ; rdfs:comment "The ankle-brachial index (ABI; the ratio of systolic blood pressure in the ankle to that in the arm), is a measure of occlusion of peripheral arteries in the leg. Peripheral arterial stenosis may be observed with atherosclerosis and with increased intima media thickness as seen in diseases such as pseudoxanthoma elasticum. The most common cause of peripheral arterial stenosis in patients over 40 years of age is atherosclerosis. Cerebral and coronary arteries are by definition not included in peripheral artery disease." ; rdfs:label "Peripheral arterial stenosis" ; rdfs:subClassOf obo:HP_0100545 . obo:HP_0004952 obo:IAO_0000115 "A rare vascular anomaly with a direct communication between pulmonary artery and pulmonary vein without an intervening capillary bed." ; oboInOwl:hasDbXref "MSH:C562404", "SNOMEDCT_US:111289009", "UMLS:C0155675" ; oboInOwl:id "HP:0004952" ; a owl:Class ; rdfs:label "Pulmonary arteriovenous fistulas" ; rdfs:subClassOf obo:HP_0004947 . obo:HP_0004953 obo:IAO_0100001 "HP:0005112" ; oboInOwl:id "HP:0004953" ; a owl:Class ; rdfs:label "obsolete Dilatation of abdominal aorta" ; owl:deprecated true . obo:HP_0004954 obo:IAO_0100001 "HP:0004959" ; oboInOwl:id "HP:0004954" ; a owl:Class ; rdfs:label "obsolete Dilatation of the descending aorta" ; owl:deprecated true . obo:HP_0004955 obo:IAO_0000115 "Abnormal tortuous (i.e., twisted) form of arteries affecting most or all arteries." ; oboInOwl:hasDbXref "UMLS:C1836651", "UMLS:C3279191" ; oboInOwl:hasExactSynonym "Generalised arterial tortuosity", "Generalised twisted arteries", "Generalized twisted arteries" ; oboInOwl:hasRelatedSynonym "Arterial tortuosity, general", "Arterial tortuosity, generalised", "Arterial tortuosity, generalized" ; oboInOwl:id "HP:0004955" ; a owl:Class ; rdfs:label "Generalized arterial tortuosity" ; rdfs:subClassOf obo:HP_0005116 . obo:HP_0004959 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the descending thoracic aorta." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:32:00Z" ; oboInOwl:hasAlternativeId "HP:0004954" ; oboInOwl:hasBroadSynonym "Dilatation of the descending thoracic aorta" ; oboInOwl:hasDbXref "Fyler:2754", "UMLS:C4025266" ; oboInOwl:id "HP:0004959" ; a owl:Class ; rdfs:label "Descending thoracic aorta aneurysm" ; rdfs:subClassOf obo:HP_0012727 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002345 ] ) ] ] ) ] ] . obo:HP_0004960 obo:IAO_0000115 "A congenital defect with aplasia (absence) of one of the right or left pulmonary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:86252004", "UMLS:C0265905" ; oboInOwl:hasExactSynonym "Absent lung artery", "Missing pulmonary artery" ; oboInOwl:id "HP:0004960" ; a owl:Class ; rdfs:comment "This is a rare feature that has been observed in recessive lethal osteogenesis imperfecta with mutation in CRTAP." ; rdfs:label "Absent pulmonary artery" ; rdfs:subClassOf obo:HP_0030966 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004961 obo:IAO_0000115 "An anomalous origin of the left pulmonary artery, such that it arises from the posterior aspect of the right pulmonary artery and passes between the trachea and esophagus to reach the left hilum." ; oboInOwl:hasDbXref "UMLS:C1856123" ; oboInOwl:id "HP:0004961" ; a owl:Class ; rdfs:label "Pulmonary artery sling" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0004962 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta." ; oboInOwl:hasDbXref "UMLS:C1969292" ; oboInOwl:id "HP:0004962" ; a owl:Class ; rdfs:label "Thoracic aorta calcification" ; rdfs:subClassOf obo:HP_0004963 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001515 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004963 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the aorta." ; oboInOwl:hasDbXref "UMLS:C1096249" ; oboInOwl:id "HP:0004963" ; a owl:Class ; rdfs:comment "Note that the phrase \"aortic calcification\" is mainly used to describe calcification of the aortic valve rather than of the aorta itself." ; rdfs:label "Calcification of the aorta" ; rdfs:subClassOf obo:HP_0001679, obo:HP_0003207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000947 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004964 obo:IAO_0000115 "Increase in mass of the tunica media of the arteries in the pulmonary circulation." ; oboInOwl:hasAlternativeId "HP:0004939" ; oboInOwl:hasDbXref "UMLS:C1504382" ; oboInOwl:hasExactSynonym "Hypertrophy of the pulmonary artery wall" ; oboInOwl:id "HP:0004964" ; a owl:Class ; rdfs:label "Pulmonary arterial medial hypertrophy" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0004966 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the tunica media of large (conduit) arteries." ; oboInOwl:hasDbXref "UMLS:C4025265" ; oboInOwl:id "HP:0004966" ; a owl:Class ; rdfs:comment "GitHub issue: https://github.com/obophenotype/human-phenotype-ontology/issues/6877" ; rdfs:label "Medial calcification of large arteries" ; rdfs:subClassOf obo:HP_0012456 . obo:HP_0004968 obo:IAO_0000115 "Recurrent bleeding into the parenchyma of the brain." ; oboInOwl:hasDbXref "UMLS:C4025264" ; oboInOwl:hasExactSynonym "Recurrent cerebral haemorrhage", "Recurrent hemorrhagic stroke" ; oboInOwl:id "HP:0004968" ; a owl:Class ; rdfs:label "Recurrent cerebral hemorrhage" ; rdfs:subClassOf obo:HP_0001342 . obo:HP_0004969 obo:IAO_0000115 "Stenosis of a peripheral branch of the pulmonary artery." ; oboInOwl:hasAlternativeId "HP:0004957" ; oboInOwl:hasDbXref "SNOMEDCT_US:253631001", "UMLS:C0345030" ; oboInOwl:hasExactSynonym "Narrowing of peripheral lung artery", "Peripheral pulmonic stenosis", "peripheral pulmonary stenosis" ; oboInOwl:hasRelatedSynonym "Occlusion of small pulmonary arteries" ; oboInOwl:id "HP:0004969" ; a owl:Class ; rdfs:label "Peripheral pulmonary artery stenosis" ; rdfs:subClassOf obo:HP_0004415 . obo:HP_0004970 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the tubular part of the ascending aorta." ; oboInOwl:hasAlternativeId "HP:0005111", "HP:0005128" ; oboInOwl:hasBroadSynonym "Ascending aorta dilation" ; oboInOwl:hasDbXref "Fyler:2310", "Fyler:2701", "SNOMEDCT_US:253645007", "UMLS:C0345049" ; oboInOwl:hasExactSynonym "Aneurysm of the ascending tubular aorta", "Ascending aortic aneurysm", "Ascending aortic dilation", "Bulging of wall of large artery located above heart", "Dilatation of ascending aorta" ; oboInOwl:id "HP:0004970" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Ascending tubular aorta aneurysm" ; rdfs:subClassOf obo:HP_0012727 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001496 ] ) ] ] ) ] ] . obo:HP_0004971 obo:IAO_0000115 "Underdevelopment of the pulmonary artery." ; oboInOwl:hasDbXref "Fyler:2966", "SNOMEDCT_US:54682008", "UMLS:C0265910" ; oboInOwl:hasExactSynonym "Underdeveloped lung artery", "Underdeveloped pulmonary artery" ; oboInOwl:id "HP:0004971" ; a owl:Class ; rdfs:label "Pulmonary artery hypoplasia" ; rdfs:subClassOf obo:HP_0030966 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004972 obo:IAO_0000115 "An abnormal increase in the average blood pressure in an individual during a single cardiac cycle." ; oboInOwl:hasDbXref "UMLS:C1840376" ; oboInOwl:id "HP:0004972" ; a owl:Class ; rdfs:label "Elevated mean arterial pressure" ; rdfs:subClassOf obo:HP_0032263 . obo:HP_0004974 obo:IAO_0000115 "Coarctation of the aorta is a narrowing or constriction of a segment of the abdominal aorta." ; oboInOwl:hasDbXref "UMLS:C4025263" ; oboInOwl:id "HP:0004974" ; a owl:Class ; rdfs:label "Coarctation of abdominal aorta" ; rdfs:subClassOf obo:HP_0001680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004975 obo:IAO_0000115 "Flaring of distal femur." ; oboInOwl:hasAlternativeId "HP:0006422" ; oboInOwl:hasDbXref "UMLS:C1855895" ; oboInOwl:hasExactSynonym "Erlenmeyer flask deformity of distal femur", "Erlenmeyer flask femora", "Erlenmeyer flask shaped thighbone" ; oboInOwl:id "HP:0004975" ; a owl:Class ; rdfs:label "Erlenmeyer flask deformity of the femurs" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0004976 oboInOwl:hasAlternativeId "HP:0006469" ; oboInOwl:hasDbXref "MSH:D031221", "SNOMEDCT_US:58320001", "UMLS:C0159970" ; oboInOwl:hasExactSynonym "Dislocations of the knees", "Knee dislocations" ; oboInOwl:id "HP:0004976" ; a owl:Class ; rdfs:label "Knee dislocation" ; rdfs:subClassOf obo:HP_0030311, obo:HP_0034670 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001485 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004977 obo:IAO_0000115 "Missing radius bone on both sides associated with congenital failure of development." ; oboInOwl:hasAlternativeId "HP:0005870" ; oboInOwl:hasDbXref "UMLS:C1848840" ; oboInOwl:hasExactSynonym "Bilateral absence of radius" ; oboInOwl:id "HP:0004977" ; a owl:Class ; rdfs:label "Bilateral radial aplasia" ; rdfs:subClassOf obo:HP_0003974 . obo:HP_0004979 obo:IAO_0000115 "Abnormally increased density of metaphyseal bone." ; oboInOwl:hasDbXref "UMLS:C3552526" ; oboInOwl:hasExactSynonym "Increased bone density in wide portion of long bone", "Sclerotic metaphyses" ; oboInOwl:id "HP:0004979" ; a owl:Class ; rdfs:label "Metaphyseal sclerosis" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0004980 obo:IAO_0000115 "Reduction in density of metaphyseal bony tissue." ; oboInOwl:hasDbXref "UMLS:C1832146" ; oboInOwl:hasExactSynonym "Rarefaction of the metaphyses" ; oboInOwl:id "HP:0004980" ; a owl:Class ; rdfs:label "Metaphyseal rarefaction" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0004981 oboInOwl:hasDbXref "UMLS:C4025262" ; oboInOwl:id "HP:0004981" ; a owl:Class ; rdfs:label "Prominent styloid process of ulna" ; rdfs:subClassOf obo:HP_0004035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011575 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004986 obo:IAO_0100001 "HP:0006381" ; oboInOwl:id "HP:0004986" ; a owl:Class ; rdfs:label "obsolete Rudimentary to absent fibulae" ; owl:deprecated true . obo:HP_0004987 obo:IAO_0000115 "Shortening of the middle parts of the leg in relation to the upper and terminal segments." ; oboInOwl:hasDbXref "UMLS:C1969178" ; oboInOwl:hasExactSynonym "Mesomelia of the lower limbs", "Mesomelic lower limb shortening" ; oboInOwl:id "HP:0004987" ; a owl:Class ; rdfs:label "Mesomelic leg shortening" ; rdfs:subClassOf obo:HP_0003027 . obo:HP_0004990 oboInOwl:hasDbXref "UMLS:C1858039" ; oboInOwl:id "HP:0004990" ; a owl:Class ; rdfs:label "Epiphyseal streaking" ; rdfs:subClassOf obo:HP_0005930 . obo:HP_0004991 obo:IAO_0000115 "Disproportionate shortening of the proximal segment of the arm (i.e. the humerus)." ; oboInOwl:hasDbXref "UMLS:C1969532" ; oboInOwl:id "HP:0004991" ; a owl:Class ; rdfs:label "Rhizomelic arm shortening" ; rdfs:subClassOf obo:HP_0008905 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0008905 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003822 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0004993 obo:IAO_0000115 "Reduced diameter of a long bone with a more pronounced reduction of the diameter of the diaphysis of the long bones." ; oboInOwl:hasDbXref "UMLS:C2675547" ; oboInOwl:hasExactSynonym "Slender long bones with narrow shaft" ; oboInOwl:id "HP:0004993" ; a owl:Class ; rdfs:label "Slender long bones with narrow diaphyses" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0003100 . obo:HP_0004997 oboInOwl:hasDbXref "UMLS:C1857192" ; oboInOwl:id "HP:0004997" ; a owl:Class ; rdfs:label "Multicentric ossification of proximal humeral epiphyses" ; rdfs:subClassOf obo:HP_0003897 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004411 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005001 obo:IAO_0000115 "Patellar dislocation occurring repeated times." ; oboInOwl:hasDbXref "SNOMEDCT_US:202246002", "UMLS:C0409412" ; oboInOwl:hasExactSynonym "Recurrent dislocation of patellas" ; oboInOwl:id "HP:0005001" ; a owl:Class ; rdfs:label "Recurrent patellar dislocation" ; rdfs:subClassOf obo:HP_0002999, obo:HP_0031869 . obo:HP_0005003 obo:IAO_0000115 "Absence or underdevelopment of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C4025261" ; oboInOwl:hasExactSynonym "Absent/small end part of innermost thighbone", "Absent/underdeveloped end part of innermost thighbone" ; oboInOwl:id "HP:0005003" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0010574, obo:HP_0010577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005004 obo:IAO_0000115 "An abnormally flat form of the proximal epiphysis of the radius." ; oboInOwl:hasDbXref "UMLS:C1849065" ; oboInOwl:id "HP:0005004" ; a owl:Class ; rdfs:label "Flattened proximal radial epiphyses" ; rdfs:subClassOf obo:HP_0004002, obo:HP_0010597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005005 obo:IAO_0000115 "Congenital onset bending or abnormal curvature of the femur that normalizes with age." ; oboInOwl:hasDbXref "UMLS:C1833754" ; oboInOwl:hasExactSynonym "Bowing of thighbone at birth, straightening with time" ; oboInOwl:id "HP:0005005" ; a owl:Class ; rdfs:comment "This feature can be diagnosed based on the medical history of congenital femoral bowing with spontaneous improvement." ; rdfs:label "Femoral bowing present at birth, straightening with time" ; rdfs:subClassOf obo:HP_0002980 . obo:HP_0005008 oboInOwl:hasDbXref "UMLS:C4025260" ; oboInOwl:hasExactSynonym "Large joint dislocations" ; oboInOwl:id "HP:0005008" ; a owl:Class ; rdfs:label "Large joint dislocations" ; rdfs:subClassOf obo:HP_0001373 . obo:HP_0005009 obo:IAO_0000115 "The humerus is shortened and displays flaring (widening) of the metaphyses." ; oboInOwl:hasDbXref "UMLS:C4025259" ; oboInOwl:hasExactSynonym "Dumbbell-shaped long bone in upper arm" ; oboInOwl:id "HP:0005009" ; a owl:Class ; rdfs:label "Dumbbell-shaped humerus" ; rdfs:subClassOf obo:HP_0000947 . obo:HP_0005010 oboInOwl:hasDbXref "UMLS:C1864975" ; oboInOwl:id "HP:0005010" ; a owl:Class ; rdfs:label "Osteomyelitis leading to amputation due to slow healing fractures" ; rdfs:subClassOf obo:HP_0002754 . obo:HP_0005011 obo:IAO_0000115 "Shortening of the middle parts of the arm in relation to the upper and terminal segments." ; oboInOwl:hasAlternativeId "HP:0005024", "HP:0006455" ; oboInOwl:hasDbXref "UMLS:C1862087" ; oboInOwl:hasExactSynonym "Mesomelia of the upper limbs", "Upper limb brachymesomelia" ; oboInOwl:id "HP:0005011" ; a owl:Class ; rdfs:label "Mesomelic arm shortening" ; rdfs:subClassOf obo:HP_0003027 . obo:HP_0005013 obo:IAO_0000115 "Abnormally developed (dysplastic) distal epiphysis of the radius." ; oboInOwl:hasDbXref "UMLS:C1862131" ; oboInOwl:id "HP:0005013" ; a owl:Class ; rdfs:label "Dysplastic distal radial epiphyses" ; rdfs:subClassOf obo:HP_0010597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005017 oboInOwl:hasDbXref "UMLS:C4025258" ; oboInOwl:id "HP:0005017" ; a owl:Class ; rdfs:label "Polyarticular chondrocalcinosis" ; rdfs:subClassOf obo:HP_0000934 . obo:HP_0005019 oboInOwl:hasDbXref "UMLS:C1835473" ; oboInOwl:hasExactSynonym "Thickening of shaft or central part of long bones" ; oboInOwl:id "HP:0005019" ; a owl:Class ; rdfs:label "Diaphyseal thickening" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005021 oboInOwl:hasDbXref "UMLS:C3278429" ; oboInOwl:hasExactSynonym "Dislocated elbows on both sides" ; oboInOwl:id "HP:0005021" ; a owl:Class ; rdfs:label "Bilateral elbow dislocations" ; rdfs:subClassOf obo:HP_0003042 . obo:HP_0005025 obo:IAO_0000115 "Underdevelopment of the distal portion of the humerus." ; oboInOwl:hasDbXref "UMLS:C1968607" ; oboInOwl:id "HP:0005025" ; a owl:Class ; rdfs:label "Hypoplastic distal humeri" ; rdfs:subClassOf obo:HP_0006507 . obo:HP_0005026 oboInOwl:hasDbXref "UMLS:C1866239" ; oboInOwl:id "HP:0005026" ; a owl:Class ; rdfs:label "Mesomelic/rhizomelic limb shortening" ; rdfs:subClassOf obo:HP_0008905 . obo:HP_0005028 oboInOwl:hasDbXref "UMLS:C1836187" ; oboInOwl:hasExactSynonym "Wide innermost wide portion of shankbone bone", "Wide innermost wide portion of shinbone bone" ; oboInOwl:id "HP:0005028" ; a owl:Class ; rdfs:label "Widened proximal tibial metaphyses" ; rdfs:subClassOf obo:HP_0003016 . obo:HP_0005033 obo:IAO_0000115 "Underdevelopment of the distal portion of the ulna." ; oboInOwl:hasAlternativeId "HP:0006474" ; oboInOwl:hasDbXref "UMLS:C1833145" ; oboInOwl:hasExactSynonym "Distal shortening of ulna", "Hypoplastic distal ulna" ; oboInOwl:id "HP:0005033" ; a owl:Class ; rdfs:label "Distal ulnar hypoplasia" ; rdfs:subClassOf obo:HP_0003022 . obo:HP_0005035 obo:IAO_0000115 "Developmental hypoplasia (shortening) of all phalanges of the foot." ; oboInOwl:hasDbXref "UMLS:C4025257" ; oboInOwl:hasExactSynonym "Short toe bones" ; oboInOwl:id "HP:0005035" ; a owl:Class ; rdfs:label "Shortening of all phalanges of the toes" ; rdfs:subClassOf obo:HP_0001831, obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005036 obo:IAO_0000115 "Underdevelopment of the ulna on only one side." ; oboInOwl:hasDbXref "UMLS:C1837832" ; oboInOwl:id "HP:0005036" ; a owl:Class ; rdfs:label "Unilateral ulnar hypoplasia" ; rdfs:subClassOf obo:HP_0003022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0005037 obo:IAO_0000115 "An abnormal osseous union (fusion) between the proximal portions of the radius and the ulna." ; oboInOwl:hasDbXref "UMLS:C2676443" ; oboInOwl:id "HP:0005037" ; a owl:Class ; rdfs:label "Proximal radio-ulnar synostosis" ; rdfs:subClassOf obo:HP_0002974 . obo:HP_0005039 obo:IAO_0000115 "Multiple exostoses originating in long bones." ; oboInOwl:hasDbXref "UMLS:C1835583" ; oboInOwl:hasExactSynonym "Multiple exostoses of long tubular bones" ; oboInOwl:id "HP:0005039" ; a owl:Class ; rdfs:label "Multiple long-bone exostoses" ; rdfs:subClassOf obo:HP_0002762 . obo:HP_0005041 obo:IAO_0000115 "Irregular surface of the normally relatively smooth capital femoral epiphysis." ; oboInOwl:hasAlternativeId "HP:0008806" ; oboInOwl:hasDbXref "UMLS:C4020825" ; oboInOwl:hasExactSynonym "Irregular end part of innermost thighbone", "Irregular proximal femoral epiphyses" ; oboInOwl:hasRelatedSynonym "Irregular capital femoral epiphyses" ; oboInOwl:id "HP:0005041" ; a owl:Class ; rdfs:label "Irregular capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0006361, obo:HP_0010574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005042 oboInOwl:hasDbXref "UMLS:C1866700" ; oboInOwl:id "HP:0005042" ; a owl:Class ; rdfs:label "Irregular, rachitic-like metaphyses" ; rdfs:subClassOf obo:HP_0003025 . obo:HP_0005043 obo:IAO_0000115 "Irregularity of the normally smooth surface of the metaphysis at the proximal end of the humerus (at the shoulder)." ; oboInOwl:hasDbXref "UMLS:C1865128" ; oboInOwl:hasExactSynonym "Irregular proximal humeral metaphyses" ; oboInOwl:id "HP:0005043" ; a owl:Class ; rdfs:label "Proximal humeral metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003913 . obo:HP_0005045 obo:IAO_0000115 "An elevation in bone density of the cortex of one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C1833739" ; oboInOwl:id "HP:0005045" ; a owl:Class ; rdfs:label "Diaphyseal cortical sclerosis" ; rdfs:subClassOf obo:HP_0003034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0016423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005048 oboInOwl:hasDbXref "UMLS:C1836193" ; oboInOwl:hasExactSynonym "Fusion of wrist bones" ; oboInOwl:id "HP:0005048" ; a owl:Class ; rdfs:label "Synostosis of carpal bones" ; rdfs:subClassOf obo:HP_0009702 . obo:HP_0005050 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint in an anterolateral direction." ; oboInOwl:hasDbXref "UMLS:C1968610" ; oboInOwl:hasExactSynonym "Anterior/lateral radial head dislocation" ; oboInOwl:id "HP:0005050" ; a owl:Class ; rdfs:label "Anterolateral radial head dislocation" ; rdfs:subClassOf obo:HP_0003083 . obo:HP_0005054 obo:IAO_0000115 "Bony outgrowths that extend laterally from the margin of the metaphysis." ; oboInOwl:hasAlternativeId "HP:0005088" ; oboInOwl:hasDbXref "UMLS:C1832988" ; oboInOwl:id "HP:0005054" ; a owl:Class ; rdfs:label "Metaphyseal spurs" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0005059 oboInOwl:hasDbXref "UMLS:C4025256" ; oboInOwl:hasExactSynonym "Joint pain/Joint inflammation" ; oboInOwl:id "HP:0005059" ; a owl:Class ; rdfs:label "Arthralgia/arthritis" ; rdfs:subClassOf obo:HP_0001369, obo:HP_0002829 . obo:HP_0005060 oboInOwl:hasDbXref "UMLS:C1968605" ; oboInOwl:id "HP:0005060" ; a owl:Class ; rdfs:label "Limited elbow flexion/extension" ; rdfs:subClassOf obo:HP_0001377, obo:HP_0006376 . obo:HP_0005063 oboInOwl:hasDbXref "UMLS:C1867494" ; oboInOwl:hasExactSynonym "Fragmented, irregular end part of bone" ; oboInOwl:id "HP:0005063" ; a owl:Class ; rdfs:label "Fragmented, irregular epiphyses" ; rdfs:subClassOf obo:HP_0010582, obo:HP_0100168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010582 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0100168 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005066 oboInOwl:hasDbXref "UMLS:C4025255" ; oboInOwl:hasExactSynonym "Cone-shaped end part of long bone fused within their wide portion of wide bone" ; oboInOwl:id "HP:0005066" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses fused within their metaphyses" ; rdfs:subClassOf obo:HP_0010579 . obo:HP_0005067 obo:IAO_0000115 "Overgrowth of the proximal part of the fibula." ; oboInOwl:hasDbXref "UMLS:C2673395" ; oboInOwl:hasExactSynonym "Overgrowth of innermost part of calf bone" ; oboInOwl:id "HP:0005067" ; a owl:Class ; rdfs:label "Proximal fibular overgrowth" ; rdfs:subClassOf obo:HP_0003099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005068 oboInOwl:hasDbXref "UMLS:C4025254" ; oboInOwl:id "HP:0005068" ; a owl:Class ; rdfs:label "Absent styloid process of ulna" ; rdfs:subClassOf obo:HP_0004035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011575 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005069 oboInOwl:hasDbXref "UMLS:C2673654" ; oboInOwl:id "HP:0005069" ; a owl:Class ; rdfs:label "Rhizo-meso-acromelic limb shortening" ; rdfs:subClassOf obo:HP_0008905 . obo:HP_0005070 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint in an proximal direction." ; oboInOwl:hasDbXref "UMLS:C1865570" ; oboInOwl:id "HP:0005070" ; a owl:Class ; rdfs:label "Proximal radial head dislocation" ; rdfs:subClassOf obo:HP_0003083 . obo:HP_0005072 obo:IAO_0000115 "The ability of the wrist joints to move beyond their normal range of motion." ; oboInOwl:hasDbXref "UMLS:C1850853" ; oboInOwl:hasExactSynonym "Increased laxity of wrists", "Increased wrist mobility" ; oboInOwl:id "HP:0005072" ; a owl:Class ; rdfs:label "Hyperextensibility at wrists" ; rdfs:subClassOf obo:HP_0001382 . obo:HP_0005084 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint in an anterior direction." ; oboInOwl:hasDbXref "UMLS:C2674451" ; oboInOwl:hasExactSynonym "Anterior dislocation of radial head" ; oboInOwl:id "HP:0005084" ; a owl:Class ; rdfs:label "Anterior radial head dislocation" ; rdfs:subClassOf obo:HP_0003083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001921 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005085 obo:IAO_0000115 "A limited ability of the knee joint to perform extension and flexion." ; oboInOwl:hasDbXref "UMLS:C1968606" ; oboInOwl:id "HP:0005085" ; a owl:Class ; rdfs:label "Limited knee flexion/extension" ; rdfs:subClassOf obo:HP_0010501 . obo:HP_0005086 oboInOwl:hasDbXref "MSH:D020370", "SNOMEDCT_US:239873007", "UMLS:C0409959" ; oboInOwl:id "HP:0005086" ; a owl:Class ; rdfs:label "Knee osteoarthritis" ; rdfs:subClassOf obo:HP_0002758, obo:HP_0034669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005089 obo:IAO_0000115 "An abnormality of the pattern of trabecula (small interconnecting rods of bone) in a metaphyseal region of bone." ; oboInOwl:hasAlternativeId "HP:0006360" ; oboInOwl:hasDbXref "UMLS:C1857139" ; oboInOwl:id "HP:0005089" ; a owl:Class ; rdfs:label "Abnormal metaphyseal trabeculation" ; rdfs:subClassOf obo:HP_0000944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060343 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001437 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005090 obo:IAO_0000115 "A lateral bending or abnormal curvature of the femur." ; oboInOwl:hasAlternativeId "HP:0005022" ; oboInOwl:hasDbXref "UMLS:C1866737" ; oboInOwl:id "HP:0005090" ; a owl:Class ; rdfs:label "Lateral femoral bowing" ; rdfs:subClassOf obo:HP_0002980 . obo:HP_0005092 obo:IAO_0000115 "The presence of streaks (bands) of abnormally increased density of metaphyseal bone." ; oboInOwl:hasDbXref "UMLS:C4025253" ; oboInOwl:hasExactSynonym "Streak increase in bone density in wide portion of wide bone" ; oboInOwl:id "HP:0005092" ; a owl:Class ; rdfs:label "Streaky metaphyseal sclerosis" ; rdfs:subClassOf obo:HP_0004979 . obo:HP_0005093 obo:IAO_0000115 "Absence of the proximal radial epiphysis." ; oboInOwl:hasDbXref "UMLS:C1855301" ; oboInOwl:id "HP:0005093" ; a owl:Class ; rdfs:label "Absent proximal radial epiphyses" ; rdfs:subClassOf obo:HP_0010577, obo:HP_0010596 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005096 obo:IAO_0000115 "A bending or abnormal curvature of the distal portion of the femur." ; oboInOwl:hasDbXref "UMLS:C1860107" ; oboInOwl:id "HP:0005096" ; a owl:Class ; rdfs:label "Distal femoral bowing" ; rdfs:subClassOf obo:HP_0002980 . obo:HP_0005099 obo:IAO_0100001 "HP:0001789" ; oboInOwl:hasExactSynonym "Severe hydrops" ; oboInOwl:id "HP:0005099" ; a owl:Class ; rdfs:label "obsolete Severe hydrops fetalis" ; owl:deprecated true . obo:HP_0005100 oboInOwl:hasDbXref "UMLS:C1851833" ; oboInOwl:hasExactSynonym "Premature birth following premature rupture of foetal membranes" ; oboInOwl:id "HP:0005100" ; a owl:Class ; rdfs:label "Premature birth following premature rupture of fetal membranes" ; rdfs:subClassOf obo:HP_0001622, obo:HP_0001788 . obo:HP_0005101 obo:IAO_0000115 "A type of hearing impairment affecting primarily the higher frequencies of sound (3,000 to 6,000 Hz)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T05:03:00Z" ; oboInOwl:hasAlternativeId "HP:0008522", "HP:0008584", "HP:0008597" ; oboInOwl:hasDbXref "MSH:D006316", "SNOMEDCT_US:232326009", "SNOMEDCT_US:48758008", "UMLS:C0018780" ; oboInOwl:hasExactSynonym "Hearing loss, high-frequency", "High frequency hearing loss", "High-frequency deafness", "Progressive high frequency hearing loss", "Progressive high-frequency hearing loss" ; oboInOwl:id "HP:0005101" ; a owl:Class ; rdfs:comment "High frequency hearing impairment often involves loss of ability to hear consonants such as s, f, t, and z, even though vowels can be heard normally." ; rdfs:label "High-frequency hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0005102 obo:IAO_0000115 "Deterioration or loss of the tissues of the cochlea." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T05:06:00Z" ; oboInOwl:hasAlternativeId "HP:0008156" ; oboInOwl:hasDbXref "UMLS:C1849095" ; oboInOwl:hasExactSynonym "Progressive cochlear degeneration" ; oboInOwl:id "HP:0005102" ; a owl:Class ; rdfs:label "Cochlear degeneration" ; rdfs:subClassOf obo:HP_0000375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005103 obo:IAO_0000115 "Ossification affecting the external ear cartilage." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T05:09:00Z" ; oboInOwl:hasAlternativeId "HP:0008549" ; oboInOwl:hasDbXref "UMLS:C1408806" ; oboInOwl:hasExactSynonym "Cartilaginous ossification of pinnae", "Ossification of pinnae", "Petrified ear" ; oboInOwl:hasRelatedSynonym "Ear cartilage calcification" ; oboInOwl:id "HP:0005103" ; a owl:Class ; rdfs:label "Calcification of the auricular cartilage" ; rdfs:subClassOf obo:HP_0000377, obo:HP_0100593, obo:HP_3000022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005104 obo:IAO_0000115 "Underdevelopment of the nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T05:15:00Z" ; oboInOwl:hasDbXref "UMLS:C1861328" ; oboInOwl:hasExactSynonym "Decreased size of nasal septum", "Decreased size of septum of nose", "Hypoplasia of septum of nose", "Small nasal septum", "Small septum of nose" ; oboInOwl:id "HP:0005104" ; a owl:Class ; rdfs:label "Hypoplastic nasal septum" ; rdfs:subClassOf obo:HP_0009935 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005105 dcterms:creator ; oboInOwl:creation_date "2008-03-25T05:21:00Z" ; oboInOwl:hasDbXref "Fyler:4870", "UMLS:C4025252" ; oboInOwl:hasExactSynonym "Abnormal nose morphology", "Abnormal of morphology of nose", "Abnormal of nasal shape", "Abnormal of shape of nose" ; oboInOwl:id "HP:0005105" ; a owl:Class ; rdfs:comment "This is a category for overall abnormal morphology that may be replaced later with more exact descriptions." ; rdfs:label "Abnormal nasal morphology" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005106 obo:IAO_0000115 "Any abnormality of the vertebral end plates, which are the top and bottom portions of the vertebral bodies that interface with the vertebral discs." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:01:00Z" ; oboInOwl:hasDbXref "UMLS:C4025251" ; oboInOwl:id "HP:0005106" ; a owl:Class ; rdfs:label "Abnormality of the vertebral endplates" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005107 obo:IAO_0000115 "An abnormality of the sacral bone." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:03:00Z" ; oboInOwl:hasDbXref "UMLS:C4025250" ; oboInOwl:hasExactSynonym "Abnormality of the sacrum" ; oboInOwl:id "HP:0005107" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The sacrum is the large, roughly triangular bone at the base of the verterbal column that is formed by fusion of the five sacral vertebrae S1 to S5." ; rdfs:label "Abnormal sacrum morphology" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005108 obo:IAO_0000115 "Any structural abnormality of the intervertebral disk." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:05:00Z" ; oboInOwl:hasDbXref "UMLS:C4025249" ; oboInOwl:hasExactSynonym "Abnormality of the intervertebral disc", "Abnormality of the intervertebral disk" ; oboInOwl:id "HP:0005108" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Any abnormality of the fibrocartilaginous structures that are located between adjacent vertebral bodies." ; rdfs:label "Abnormal intervertebral disk morphology" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005109 obo:IAO_0000115 "An abnormality of the Achilles tendon." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:21:00Z" ; oboInOwl:hasDbXref "UMLS:C4021642" ; oboInOwl:hasExactSynonym "Abnormality of the Achilles tendon", "Abnormality of the calcaneal tendon" ; oboInOwl:id "HP:0005109" ; a owl:Class ; rdfs:label "Abnormality of the Achilles tendon" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0100261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005110 obo:IAO_0000115 "An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:29:00Z" ; oboInOwl:hasAlternativeId "HP:0001715", "HP:0005179" ; oboInOwl:hasDbXref "MSH:D001281", "SNOMEDCT_US:49436004", "UMLS:C0004238" ; oboInOwl:hasExactSynonym "Quivering upper heart chambers resulting in irregular heartbeat" ; oboInOwl:id "HP:0005110" ; a owl:Class ; rdfs:comment "The ventricular response to atrial fibrillation is irregularly irregular because of the large number of atrial impulses that transit the atrioventricular node, making the ventricle partially refractory to further impulses. Atrial fibrillation can cause a number of manifestations including excessive ventricular response with angina pectoris or hypotension in susceptible individuals, syncope, systemic embolization, fatigue, or anxiety. These features should be coded separately." ; rdfs:label "Atrial fibrillation" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0005111 obo:IAO_0100001 "HP:0004970" ; oboInOwl:id "HP:0005111" ; a owl:Class ; rdfs:label "obsolete Dilatation of the ascending aorta" ; owl:deprecated true . obo:HP_0005112 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the abdominal aorta." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:33:00Z" ; oboInOwl:hasAlternativeId "HP:0004953" ; oboInOwl:hasBroadSynonym "Dilatation of the abdominal aorta" ; oboInOwl:hasDbXref "UMLS:C4025248" ; oboInOwl:id "HP:0005112" ; a owl:Class ; rdfs:label "Abdominal aortic aneurysm" ; rdfs:subClassOf obo:HP_0004942 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001516 ] ) ] ] ) ] ] . obo:HP_0005113 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the aortic arch." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:34:00Z" ; oboInOwl:hasAlternativeId "HP:0004965" ; oboInOwl:hasBroadSynonym "Aortic arch dilatation", "Dilatation of the aortic arch" ; oboInOwl:hasDbXref "Fyler:2706", "UMLS:C1851119" ; oboInOwl:id "HP:0005113" ; a owl:Class ; rdfs:label "Aortic arch aneurysm" ; rdfs:subClassOf obo:HP_0012727 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001508 ] ) ] ] ) ] ] . obo:HP_0005114 obo:IAO_0100001 "HP:0011004" ; oboInOwl:id "HP:0005114" ; a owl:Class ; rdfs:label "obsolete Abnormalities of the peripheral arteries" ; owl:deprecated true . obo:HP_0005115 obo:IAO_0000115 "A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:37:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:72654001", "UMLS:C0428974" ; oboInOwl:hasExactSynonym "Supraventricular arrhythmias" ; oboInOwl:id "HP:0005115" ; a owl:Class ; rdfs:comment "Supraventricular arrhythmia includes atrial arrhythmias (atrial tachycardia, atrial flutter, atrial fibrillation), atrioventricular nodal reentrant tachycardia, junctional ectopic tachycardia, atrioventricular reentrant tachycardia (Wolf-Parkinson-White Syndrome), orthodromic or antidromic. Supraventricular arrhythmia is distinct from ventricular tachycardia, which originates in the ventricles." ; rdfs:label "Supraventricular arrhythmia" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0005116 obo:IAO_0000115 "Abnormal tortuous (i.e., twisted) form of arteries." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:39:00Z" ; oboInOwl:hasDbXref "UMLS:C3279191" ; oboInOwl:id "HP:0005116" ; a owl:Class ; rdfs:label "Arterial tortuosity" ; rdfs:subClassOf obo:HP_0004948, obo:HP_0011004 . obo:HP_0005117 obo:IAO_0000115 "Abnormal increase in diastolic blood pressure." ; dcterms:creator ; oboInOwl:creation_date "2008-03-25T06:43:00Z" ; oboInOwl:hasDbXref "UMLS:C1840375" ; oboInOwl:hasExactSynonym "Elevated diastolic BP" ; oboInOwl:id "HP:0005117" ; a owl:Class ; rdfs:comment "Normal diastolic blood pressure is less than 80 mmHg." ; rdfs:label "Elevated diastolic blood pressure" ; rdfs:subClassOf obo:HP_0032263 . obo:HP_0005120 obo:IAO_0000115 "Any structural abnormality of a cardiac atrium." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:12:00Z" ; oboInOwl:hasDbXref "UMLS:C4025246" ; oboInOwl:hasExactSynonym "Abnormality of cardiac atrium morphology", "Abnormality of heart atrium" ; oboInOwl:id "HP:0005120" ; a owl:Class ; rdfs:label "Abnormal cardiac atrium morphology" ; rdfs:subClassOf obo:HP_0001627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002081 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005121 obo:IAO_0000115 "An excessive concavity of the posterior surface of one or more vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0004572", "HP:0004579" ; oboInOwl:hasDbXref "UMLS:C1850196" ; oboInOwl:hasExactSynonym "Posterior vertebral body scalloping" ; oboInOwl:id "HP:0005121" ; a owl:Class ; rdfs:comment "The posterior vertebral scalloping sign appears on a lateral radiograph of the spine as an exaggeration of the normal concavity of the posterior surface of one or more vertebral bodies. Neurofibromatosis may be associated with marked scalloping of the posterior borders of the vertebral bodies resulting from intraspinal tumors." ; rdfs:label "Posterior scalloping of vertebral bodies" ; rdfs:subClassOf obo:HP_0004586 . obo:HP_0005129 oboInOwl:hasDbXref "UMLS:C1855901" ; oboInOwl:id "HP:0005129" ; a owl:Class ; rdfs:label "Congenital hypertrophy of left ventricle" ; rdfs:subClassOf obo:HP_0001712 . obo:HP_0005130 obo:IAO_0100001 "HP:0001723" ; oboInOwl:id "HP:0005130" ; a owl:Class ; rdfs:label "obsolete Restrictive heart failure" ; owl:deprecated true . obo:HP_0005132 obo:IAO_0000115 "Compression of the heart caused by rigid, thickened, or fused pericardial membranes." ; oboInOwl:hasDbXref "UMLS:C0240709" ; oboInOwl:id "HP:0005132" ; a owl:Class ; rdfs:label "Pericardial constriction" ; rdfs:subClassOf obo:HP_0001697 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005133 obo:IAO_0000115 "Enlargement of the chamber of the right ventricle." ; oboInOwl:hasDbXref "Fyler:1827", "Fyler:2333", "SNOMEDCT_US:253522006", "UMLS:C0344893" ; oboInOwl:hasExactSynonym "Dilated heart right ventricle" ; oboInOwl:id "HP:0005133" ; a owl:Class ; rdfs:label "Right ventricular dilatation" ; rdfs:subClassOf obo:HP_0001707 . obo:HP_0005134 obo:IAO_0000115 "Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries." ; oboInOwl:hasAlternativeId "HP:0005131" ; oboInOwl:hasDbXref "SNOMEDCT_US:6996004", "UMLS:C0265831" ; oboInOwl:hasExactSynonym "Absent pulmonary valve" ; oboInOwl:id "HP:0005134" ; a owl:Class ; rdfs:comment "The distinctive feature of APVS is the airway obstruction caused by tracheobronchial compression that results from massive dilatation of the main pulmonary artery (PA) and its first- and second-order branches. Consequential tracheomalacia and bronchomalacia determine the timing and severity of respiratory compromise, as well as the morbidity and mortality of these patients." ; rdfs:label "Absence of the pulmonary valve" ; rdfs:subClassOf obo:HP_0001641 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005135 obo:IAO_0000115 "An abnormality of the T wave on the electrocardiogram, which mainly represents the repolarization of the ventricles." ; oboInOwl:hasDbXref "UMLS:C4025245" ; oboInOwl:hasExactSynonym "EKG: T-wave abnormalities", "T-wave abnormalities" ; oboInOwl:id "HP:0005135" ; a owl:Class ; rdfs:label "Abnormal T-wave" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0005136 obo:IAO_0000115 "Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus." ; oboInOwl:hasDbXref "UMLS:C1835130" ; oboInOwl:hasExactSynonym "Premature calcification of mitral annulus" ; oboInOwl:id "HP:0005136" ; a owl:Class ; rdfs:comment "MAC is a common degenerative process involving the fibrous annulus of the mitral valve, and is generally an incidental finding associated with aging. This term applies if MAC occurs at a substantially younger age than usual." ; rdfs:label "Mitral annular calcification" ; rdfs:subClassOf obo:HP_0004382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005141 obo:IAO_0100001 "HP:0004751" ; oboInOwl:id "HP:0005141" ; a owl:Class ; rdfs:label "obsolete Episodes of ventricular tachycardia" ; owl:deprecated true . obo:HP_0005143 obo:IAO_0000115 "The right pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery." ; oboInOwl:hasDbXref "SNOMEDCT_US:253634009", "UMLS:C0345037" ; oboInOwl:id "HP:0005143" ; a owl:Class ; rdfs:label "Anomalous origin of right pulmonary artery from ascending aorta" ; rdfs:subClassOf obo:HP_0011660 . obo:HP_0005144 obo:IAO_0000115 "The dividing wall between left and right sides of the heart, thickens and bulges into the left ventricle." ; oboInOwl:hasDbXref "UMLS:C1845019" ; oboInOwl:hasExactSynonym "Thickened interventricular septum" ; oboInOwl:id "HP:0005144" ; a owl:Class ; rdfs:label "Ventricular septal hypertrophy" ; rdfs:subClassOf obo:HP_0010438 . obo:HP_0005145 obo:IAO_0000115 "Abnormal narrowing of the coronary artery." ; oboInOwl:hasDbXref "MSH:D023921", "SNOMEDCT_US:233970002", "UMLS:C0242231" ; oboInOwl:hasExactSynonym "Narrowing of coronary artery" ; oboInOwl:id "HP:0005145" ; a owl:Class ; rdfs:label "Coronary artery stenosis" ; rdfs:subClassOf obo:HP_0006704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001621 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005146 obo:IAO_0000115 "Abnormal calcification of a cardiac valve." ; oboInOwl:hasDbXref "UMLS:C1856483" ; oboInOwl:hasExactSynonym "Calcifications of the cardiac valves" ; oboInOwl:id "HP:0005146" ; a owl:Class ; rdfs:label "Cardiac valve calcification" ; rdfs:subClassOf obo:HP_0001654, obo:HP_0011915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000946 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005147 oboInOwl:hasDbXref "UMLS:C1969410" ; oboInOwl:id "HP:0005147" ; a owl:Class ; rdfs:label "Bidirectional ventricular ectopy" ; rdfs:subClassOf obo:HP_0006682 . obo:HP_0005148 obo:IAO_0000115 "Any defect in the valve connecting the heart and the pulmonary artery." ; oboInOwl:hasDbXref "UMLS:C1860165" ; oboInOwl:id "HP:0005148" ; a owl:Class ; rdfs:label "Pulmonary valve defects" ; rdfs:subClassOf obo:HP_0001641 . obo:HP_0005150 obo:IAO_0000115 "An impairment of the electrical continuity between the atria and ventricles." ; oboInOwl:hasDbXref "UMLS:C4025244" ; oboInOwl:id "HP:0005150" ; a owl:Class ; rdfs:label "Abnormal atrioventricular conduction" ; rdfs:subClassOf obo:HP_0031546 . obo:HP_0005151 obo:IAO_0000115 "Narrowing or constriction of the aorta localized proximal to the ductus arteriosus, i.e., to the preductal region of aortic arch." ; oboInOwl:hasDbXref "SNOMEDCT_US:13867009", "UMLS:C0265878" ; oboInOwl:hasExactSynonym "Proximal aortic coarctation" ; oboInOwl:id "HP:0005151" ; a owl:Class ; rdfs:comment "Blood flow to the aorta distal to the coarctation may be dependent on a patent ductus arteriosus, and hence closure of the ductus arteriosus can lead to serious ischemia of the affected tissues." ; rdfs:label "Preductal coarctation of the aorta" ; rdfs:subClassOf obo:HP_0012305 . obo:HP_0005152 obo:IAO_0000115 "A type of cardiomyopathy characterized pathologically by hamartomatous lesions of cardiac Purkinje cells." ; oboInOwl:hasDbXref "MSH:C535584", "UMLS:C1708371" ; oboInOwl:hasExactSynonym "Arachnocytosis of the myocardium", "Foamy myocardial transformation", "Focal lipid cardiomyopathy", "Infantile cardiomyopathy with histiocytoid changes", "Infantile xanthomatous cardiomyopathy", "Isolated cardiac lipidosis", "Myocardial or conduction system hamartoma", "Oncocytic cardiomyopathy" ; oboInOwl:id "HP:0005152" ; a owl:Class ; rdfs:comment "This HPO term intends to refer to the histological changes that characterize histiocytoid cardiomyopthy. The disease entity Histiocytoid cardiomyopathy is a rare arrhythmogenic disorder characterized by incessant ventricular tachycardia, cardiomegaly, and often sudden death by age 2 years." ; rdfs:label "Histiocytoid cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005155 obo:IAO_0000115 "A ventricular escape rhythm occurs whenever higher-lever pacemakers in AV junction or sinus node fail to control ventricular activation. Escape rate is usually 20-40 bpm, often associated with broad QRS complexes (at least 120 ms)." ; oboInOwl:hasDbXref "SNOMEDCT_US:81898007", "UMLS:C0232216" ; oboInOwl:hasExactSynonym "Idioventricular escape rhythm" ; oboInOwl:id "HP:0005155" ; a owl:Class ; rdfs:label "Ventricular escape rhythm" ; rdfs:subClassOf obo:HP_0004308 . obo:HP_0005156 obo:IAO_0000115 "Underdeveloped, small left heart atrium" ; oboInOwl:hasDbXref "Fyler:3040", "UMLS:C1970625" ; oboInOwl:hasExactSynonym "Left atrium hypoplasia", "Underdeveloped left heart atrium" ; oboInOwl:id "HP:0005156" ; a owl:Class ; rdfs:label "Hypoplastic left atrium" ; rdfs:subClassOf obo:HP_0025579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005157 obo:IAO_0000115 "Hypertrophic cardiomyopathy with an symmetrical and concentric pattern of hypertrophy." ; oboInOwl:hasAlternativeId "HP:0001672" ; oboInOwl:hasDbXref "UMLS:C0238044" ; oboInOwl:hasExactSynonym "Symmetric, concentric, hypertrophic cardiomyopathy" ; oboInOwl:id "HP:0005157" ; a owl:Class ; rdfs:label "Concentric hypertrophic cardiomyopathy" ; rdfs:subClassOf obo:HP_0001639 . obo:HP_0005160 obo:IAO_0000115 "Total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium." ; oboInOwl:hasAlternativeId "HP:0005153", "HP:0005175" ; oboInOwl:hasDbXref "Fyler:0900", "Fyler:900", "MSH:D012587", "SNOMEDCT_US:111323005", "SNOMEDCT_US:39905002", "UMLS:C0036400" ; oboInOwl:hasExactSynonym "Total anomalous pulmonary venous connection", "Total anomalous pulmonary venous drainage" ; oboInOwl:id "HP:0005160" ; a owl:Class ; rdfs:comment "Pulmonary veins drain through abnormal connections to the right atrium." ; rdfs:label "Total anomalous pulmonary venous return" ; rdfs:subClassOf obo:HP_0010772 . obo:HP_0005162 obo:IAO_0000115 "Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole." ; oboInOwl:hasAlternativeId "HP:0005154" ; oboInOwl:hasDbXref "MSH:D006333", "SNOMEDCT_US:275514001", "SNOMEDCT_US:85232009", "UMLS:C0023212", "UMLS:C0553982" ; oboInOwl:hasExactSynonym "Impaired left ventricular function", "Left ventricular dysfunction", "Left ventricular failure", "Left ventricular impairment", "Left-sided heart failure" ; oboInOwl:id "HP:0005162" ; a owl:Class ; rdfs:label "Abnormal left ventricular function" ; rdfs:subClassOf obo:HP_0030872 . obo:HP_0005164 obo:IAO_0000115 "A congenital malformation of the pulmonary valve characterized by leaflet deformation." ; oboInOwl:hasDbXref "UMLS:C1866206" ; oboInOwl:hasExactSynonym "Dysplasia of pulmonary valve", "Pulmonary valve dysplasia" ; oboInOwl:id "HP:0005164" ; a owl:Class ; rdfs:label "Dysplastic pulmonary valve" ; rdfs:subClassOf obo:HP_0001641 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005165 obo:IAO_0000115 "Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long." ; oboInOwl:hasDbXref "SNOMEDCT_US:49578007", "UMLS:C0520878" ; oboInOwl:hasExactSynonym "Electrocardiographic short PR interval", "Short P-R interval", "Shortened PR interval on EKG" ; oboInOwl:id "HP:0005165" ; a owl:Class ; rdfs:label "Shortened PR interval" ; rdfs:subClassOf obo:HP_0031593 . obo:HP_0005168 obo:IAO_0000115 "An abnormal increase in magnitude of the pressure in the right atrium." ; oboInOwl:hasDbXref "UMLS:C1867421" ; oboInOwl:id "HP:0005168" ; a owl:Class ; rdfs:comment "Elevated mean right atrial pressure (RAP) can be measured by cardiac catheterization." ; rdfs:label "Elevated right atrial pressure" ; rdfs:subClassOf obo:HP_0025443 . obo:HP_0005170 obo:IAO_0000115 "A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex." ; oboInOwl:hasDbXref "UMLS:C1861987" ; oboInOwl:id "HP:0005170" ; a owl:Class ; rdfs:label "Complete heart block with broad QRS complexes" ; rdfs:subClassOf obo:HP_0001709 . obo:HP_0005172 obo:IAO_0000115 "Conduction block in the posterior division of the left bundle branch of the bundle of His." ; oboInOwl:hasDbXref "SNOMEDCT_US:62026008", "UMLS:C0264913" ; oboInOwl:hasExactSynonym "Left posterior hemiblock" ; oboInOwl:id "HP:0005172" ; a owl:Class ; rdfs:label "Left posterior fascicular block" ; rdfs:subClassOf obo:HP_0011713 . obo:HP_0005173 obo:IAO_0100001 "HP:0004380" ; oboInOwl:id "HP:0005173" ; a owl:Class ; rdfs:label "obsolete Calcific aortic valve stenosis" ; owl:deprecated true . obo:HP_0005174 obo:IAO_0000115 "Subvalvular stenosis is caused by a diaphragm-like membrane. The stenosis is clinically manifested like any other form of aortic stenosis but is often associated with some aortic insufficiency." ; oboInOwl:hasDbXref "UMLS:C1848978" ; oboInOwl:id "HP:0005174" ; a owl:Class ; rdfs:comment "An important feature in the differential diagnosis between valvular and subvalvular aortic stenosis is the fact that no ejection sound is present in the latter." ; rdfs:label "Membranous subvalvular aortic stenosis" ; rdfs:subClassOf obo:HP_0001682 . obo:HP_0005176 obo:IAO_0000115 "A congenital malformation of the aortic valve characterized by leaflet deformation." ; oboInOwl:hasDbXref "UMLS:C1866207" ; oboInOwl:id "HP:0005176" ; a owl:Class ; rdfs:label "Dysplastic aortic valve" ; rdfs:subClassOf obo:HP_0001646 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005177 obo:IAO_0000115 "Arteriosclerosis occurring at an age that is younger than usual." ; oboInOwl:hasBroadSynonym "Premature hardening of arteries" ; oboInOwl:hasDbXref "UMLS:C1848486", "UMLS:C4280503" ; oboInOwl:id "HP:0005177" ; a owl:Class ; rdfs:label "Premature arteriosclerosis" ; rdfs:subClassOf obo:HP_0002634 . obo:HP_0005178 obo:IAO_0000115 "A type of third degree heart block in which the escape rhythm arises at the atrioventricular node, which produces a narrow QRS complex." ; oboInOwl:hasDbXref "UMLS:C1841661" ; oboInOwl:id "HP:0005178" ; a owl:Class ; rdfs:label "Complete heart block with narrow QRS complexes" ; rdfs:subClassOf obo:HP_0001709 . obo:HP_0005180 obo:IAO_0000115 "Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium." ; oboInOwl:hasAlternativeId "HP:0004753" ; oboInOwl:hasDbXref "Fyler:1161", "MSH:D014262", "SNOMEDCT_US:111287006", "UMLS:C0040961" ; oboInOwl:hasExactSynonym "Tricuspid insufficiency", "Tricuspid valve regurgitation" ; oboInOwl:id "HP:0005180" ; a owl:Class ; rdfs:comment "This term should not be applied to Ebstein's anomaly of the tricuspid valve (see HP:0010316)." ; rdfs:label "Tricuspid regurgitation" ; rdfs:subClassOf obo:HP_0031651, obo:HP_0034376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005181 obo:IAO_0000115 "Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45." ; oboInOwl:hasDbXref "UMLS:C1867743" ; oboInOwl:hasExactSynonym "Premature coronary artery disease" ; oboInOwl:id "HP:0005181" ; a owl:Class ; rdfs:label "Premature coronary artery atherosclerosis" ; rdfs:subClassOf obo:HP_0001677 . obo:HP_0005182 obo:IAO_0000115 "The presence of a bicuspid pulmonary valve." ; oboInOwl:hasDbXref "Fyler:1601", "SNOMEDCT_US:253599005", "UMLS:C0344987" ; oboInOwl:id "HP:0005182" ; a owl:Class ; rdfs:comment "The pulmonary valve normally has three cusps (flaps), that is, it is normally tricuspid." ; rdfs:label "Bicuspid pulmonary valve" ; rdfs:subClassOf obo:HP_0031566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002281 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005183 obo:IAO_0000115 "An abnormal dilatation of lymph vessels in the pericardium." ; oboInOwl:hasDbXref "UMLS:C1856140" ; oboInOwl:id "HP:0005183" ; a owl:Class ; rdfs:label "Pericardial lymphangiectasia" ; rdfs:subClassOf obo:HP_0001697, obo:HP_0031842 . obo:HP_0005184 obo:IAO_0000115 "A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations." ; oboInOwl:hasDbXref "UMLS:C1560305" ; oboInOwl:id "HP:0005184" ; a owl:Class ; rdfs:label "Prolonged QTc interval" ; rdfs:subClassOf obo:HP_0001657 . obo:HP_0005185 obo:IAO_0000115 "A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly." ; oboInOwl:hasDbXref "UMLS:C1847397" ; oboInOwl:id "HP:0005185" ; a owl:Class ; rdfs:label "Global systolic dysfunction" ; rdfs:subClassOf obo:HP_0006673 . obo:HP_0005186 obo:IAO_0000115 "Synovial hyperplasia involves proliferation of mesenchymal stromal/stem cells and leads to synovial thickening, which can be observed radiographically." ; oboInOwl:hasDbXref "MSH:D013585", "SNOMEDCT_US:240206002", "UMLS:C0410574" ; oboInOwl:hasExactSynonym "Synovial hyperplasia", "Synovial hypertrophy" ; oboInOwl:id "HP:0005186" ; a owl:Class ; rdfs:comment "Synovial hyperplasia is a frequent clinical finding in patients with joint injury and other joint disorders." ; rdfs:label "Synovial lining hyperplasia" ; rdfs:subClassOf obo:HP_0005262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002217 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005187 oboInOwl:hasDbXref "UMLS:C4025243" ; oboInOwl:id "HP:0005187" ; a owl:Class ; rdfs:label "Progressive joint destruction" ; rdfs:subClassOf obo:HP_0001367 . obo:HP_0005190 oboInOwl:hasDbXref "UMLS:C4025242" ; oboInOwl:id "HP:0005190" ; a owl:Class ; rdfs:label "Proximal finger joint hyperextensibility" ; rdfs:subClassOf obo:HP_0001187 . obo:HP_0005191 oboInOwl:hasDbXref "SNOMEDCT_US:59068006", "UMLS:C0265669" ; oboInOwl:hasExactSynonym "Dislocated knee since birth" ; oboInOwl:id "HP:0005191" ; a owl:Class ; rdfs:label "Congenital knee dislocation" ; rdfs:subClassOf obo:HP_0004976 . obo:HP_0005193 oboInOwl:hasDbXref "UMLS:C4025241" ; oboInOwl:id "HP:0005193" ; a owl:Class ; rdfs:label "Restricted large joint movement" ; rdfs:subClassOf obo:HP_0001376 . obo:HP_0005194 obo:IAO_0000115 "Abnormally flat shape of the heads of the metatarsal bones." ; oboInOwl:hasDbXref "UMLS:C4025240" ; oboInOwl:hasExactSynonym "Flattened head of long bone of foot" ; oboInOwl:id "HP:0005194" ; a owl:Class ; rdfs:comment "The metatarsal heads articulate with the proximal phalanges of the toes." ; rdfs:label "Flattened metatarsal heads" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0005195 oboInOwl:hasDbXref "UMLS:C4025239" ; oboInOwl:id "HP:0005195" ; a owl:Class ; rdfs:label "Polyarticular arthropathy" ; rdfs:subClassOf obo:HP_0003040 . obo:HP_0005197 obo:IAO_0000115 "A sensation of stiffness in the joints that occurs following waking up in the morning." ; oboInOwl:hasDbXref "UMLS:C4025238" ; oboInOwl:hasExactSynonym "Generalised morning stiffness" ; oboInOwl:id "HP:0005197" ; a owl:Class ; rdfs:label "Generalized morning stiffness" ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0005198 obo:IAO_0000115 "Interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity." ; oboInOwl:hasDbXref "UMLS:C4025237" ; oboInOwl:hasExactSynonym "Stiff hinge joints" ; oboInOwl:id "HP:0005198" ; a owl:Class ; rdfs:label "Stiff interphalangeal joints" ; rdfs:subClassOf obo:HP_0001387 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006658 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005199 obo:IAO_0000115 "Absence of the abdominal musculature." ; oboInOwl:hasDbXref "UMLS:C3149223" ; oboInOwl:hasExactSynonym "Absent abdominal musculature" ; oboInOwl:id "HP:0005199" ; a owl:Class ; rdfs:label "Aplasia of the abdominal wall musculature" ; rdfs:subClassOf obo:HP_0010318 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005200 oboInOwl:hasDbXref "MSH:D012185", "SNOMEDCT_US:49120005", "UMLS:C0035357" ; oboInOwl:id "HP:0005200" ; a owl:Class ; rdfs:label "Retroperitoneal fibrosis" ; rdfs:subClassOf obo:HP_0002585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005201 oboInOwl:hasDbXref "UMLS:C4025236" ; oboInOwl:id "HP:0005201" ; a owl:Class ; rdfs:label "Anomalous splenoportal venous system" ; rdfs:subClassOf obo:HP_0031941 . obo:HP_0005202 obo:IAO_0000115 "A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach." ; oboInOwl:hasDbXref "UMLS:C0850666" ; oboInOwl:id "HP:0005202" ; a owl:Class ; rdfs:comment "The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes approximately half of the human population, but only causes overt gastric disease in a subset of infected hosts." ; rdfs:label "Helicobacter pylori infection" ; rdfs:subClassOf obo:HP_0004798 . obo:HP_0005203 obo:IAO_0000115 "The occurrence of the full-thickness tear (perforation) of the wall of the esophagus." ; oboInOwl:hasAlternativeId "HP:0005251" ; oboInOwl:hasDbXref "MSH:C536571", "SNOMEDCT_US:19995004", "UMLS:C0238115" ; oboInOwl:hasExactSynonym "Spontaneous esophageal rupture" ; oboInOwl:hasRelatedSynonym "Boerhaave syndrome" ; oboInOwl:id "HP:0005203" ; a owl:Class ; rdfs:comment "Esophageal perforation can lead to retained gastric contents, saliva, bile, and other substances entering the mediastinum, resulting in mediastinitis, which in turn may lead to sepsis." ; rdfs:label "Spontaneous esophageal perforation" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0005206 obo:IAO_0000115 "Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis." ; oboInOwl:hasDbXref "MSH:D010192", "SNOMEDCT_US:111374002", "UMLS:C0030299" ; oboInOwl:id "HP:0005206" ; a owl:Class ; rdfs:label "Pancreatic pseudocyst" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0005207 obo:IAO_0000115 "Hypertrophy of the stomach." ; oboInOwl:hasBroadSynonym "Increased stomach size" ; oboInOwl:hasDbXref "UMLS:C1834341", "UMLS:C4280502" ; oboInOwl:id "HP:0005207" ; a owl:Class ; rdfs:label "Gastric hypertrophy" ; rdfs:subClassOf obo:HP_0002577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005208 obo:IAO_0000115 "Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption." ; oboInOwl:hasDbXref "SNOMEDCT_US:15699003", "UMLS:C0267557" ; oboInOwl:hasExactSynonym "Secretory diarrhoea" ; oboInOwl:id "HP:0005208" ; a owl:Class ; rdfs:label "Secretory diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0005209 obo:IAO_0000115 "The presence of cyst of the intrahepatic bile duct." ; oboInOwl:hasDbXref "SNOMEDCT_US:235925007", "UMLS:C0400991" ; oboInOwl:id "HP:0005209" ; a owl:Class ; rdfs:label "Intrahepatic bile duct cysts" ; rdfs:subClassOf obo:HP_0011040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003704 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005210 obo:IAO_0000115 "Underdevelopment of the colon." ; oboInOwl:hasDbXref "UMLS:C1392839" ; oboInOwl:hasExactSynonym "Hypoplasia of the colon", "Underdeveloped colon" ; oboInOwl:id "HP:0005210" ; a owl:Class ; rdfs:label "Hypoplastic colon" ; rdfs:subClassOf obo:HP_0100811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005211 oboInOwl:hasDbXref "UMLS:C1849706" ; oboInOwl:id "HP:0005211" ; a owl:Class ; rdfs:label "Midgut malrotation" ; rdfs:subClassOf obo:HP_0002566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001045 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005212 obo:IAO_0000115 "Leukoplakia is a precancerous dermatosis of mucous membranes analogous Leukoplakia is basically a chronic inflammatory hypertrophy in which anaplasia and malignant dyskeratosis may develop and subsequently advance to an invasive squamous cell cancer. The clinical diagnosis of primary anal leukoplakia is indicated by single or multiple slightly raised,irregular, marginated, grayish-white keratinized' patches in the anal canal. Tissue biopsy is necessary for confirmation." ; oboInOwl:hasDbXref "UMLS:C1844632" ; oboInOwl:id "HP:0005212" ; a owl:Class ; rdfs:label "Anal mucosal leukoplakia" ; rdfs:subClassOf obo:HP_0032186 . obo:HP_0005213 obo:IAO_0000115 "The presence of abnormal calcium deposition lesions in the pancreas." ; oboInOwl:hasDbXref "UMLS:C1842406" ; oboInOwl:hasExactSynonym "Pancreatic calcifications" ; oboInOwl:id "HP:0005213" ; a owl:Class ; rdfs:label "Pancreatic calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0012090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005214 obo:IAO_0000115 "Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal." ; oboInOwl:hasAlternativeId "HP:0005239" ; oboInOwl:hasDbXref "MSH:D007415", "SNOMEDCT_US:81060008", "UMLS:C0021843" ; oboInOwl:hasExactSynonym "Bowel obstruction", "Intestinal blockage", "Intestinal obstruction" ; oboInOwl:id "HP:0005214" ; a owl:Class ; rdfs:label "Intestinal obstruction" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0004796 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005215 obo:IAO_0000115 "Increased susceptibility to Giardia lamblia infection of the intestine, as manifested by a medical history of multiple episodes of Giardia lamblia intestinal infection." ; oboInOwl:hasDbXref "UMLS:C4025235" ; oboInOwl:id "HP:0005215" ; a owl:Class ; rdfs:label "Frequent Giardia lamblia infestation" ; rdfs:subClassOf obo:HP_0004798 . obo:HP_0005216 obo:IAO_0000115 "An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing." ; oboInOwl:hasDbXref "SNOMEDCT_US:162020001", "UMLS:C0239043" ; oboInOwl:hasExactSynonym "Chewing difficulties", "Chewing difficulty", "Difficulty chewing" ; oboInOwl:id "HP:0005216" ; a owl:Class ; rdfs:comment "Chewing and swallowing are interrelated. The act of chewing plays a fundamental role in the process of swallowing food. Mastication prepares food for swallowing by breaking it into small particles. Accordingly, loss of teeth has been associated with swallowing difficulties. Chewing difficulties may be caused by loss of teeth, partial dentures, or by tooth pain. Swallowing difficulties, in contrast, are often characterized by difficulties swallowing liquids, reflux, throat spasms, choking on dry food, or dysphagia." ; rdfs:label "Impaired mastication" ; rdfs:subClassOf obo:HP_0031815 . obo:HP_0005217 oboInOwl:hasDbXref "UMLS:C4025234" ; oboInOwl:id "HP:0005217" ; a owl:Class ; rdfs:label "Duplication of internal organs" ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0005218 obo:IAO_0000115 "The presence of a fistula (abnormal tunnel) between the anal canal and the perineum." ; oboInOwl:hasBroadSynonym "Perianal fistula" ; oboInOwl:hasDbXref "UMLS:C1835798" ; oboInOwl:id "HP:0005218" ; a owl:Class ; rdfs:label "Anoperineal fistula" ; rdfs:subClassOf obo:HP_0004871, obo:HP_0010447 . obo:HP_0005219 obo:IAO_0000115 "Absence of gastric intrinsic factor, which is normally produced by the parietal cells of the stomach, and is required for the absorption of vitamin B12." ; oboInOwl:hasDbXref "UMLS:C4021641" ; oboInOwl:hasExactSynonym "Intrinsic factor absent from gastric juice" ; oboInOwl:id "HP:0005219" ; a owl:Class ; rdfs:comment "This feature can be ascertained by immunoassay of gastric juices." ; rdfs:label "Absence of intrinsic factor" ; rdfs:subClassOf obo:HP_0002577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000007975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005220 oboInOwl:hasDbXref "UMLS:C4025233" ; oboInOwl:id "HP:0005220" ; a owl:Class ; rdfs:label "Multiple intestinal neurofibromatosis" ; rdfs:subClassOf obo:HP_0001067, obo:HP_0002242, obo:HP_0007378 . obo:HP_0005222 obo:IAO_0000115 "The presence of multiple diverticula of the intestine." ; oboInOwl:hasDbXref "UMLS:C1394691", "UMLS:C1395674" ; oboInOwl:hasRelatedSynonym "Bowel diverticula" ; oboInOwl:id "HP:0005222" ; a owl:Class ; rdfs:label "Bowel diverticulosis" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_68 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005223 oboInOwl:hasDbXref "UMLS:C1850328" ; oboInOwl:id "HP:0005223" ; a owl:Class ; rdfs:label "Duplicated colon" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0100668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005224 obo:IAO_0000115 "A collection of pus in the area of the rectum." ; oboInOwl:hasAlternativeId "HP:0002567" ; oboInOwl:hasDbXref "SNOMEDCT_US:197166005", "SNOMEDCT_US:91669008", "UMLS:C0149770", "UMLS:C0267566" ; oboInOwl:hasExactSynonym "Perirectal abscess" ; oboInOwl:id "HP:0005224" ; a owl:Class ; rdfs:label "Rectal abscess" ; rdfs:subClassOf obo:HP_0002034, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005225 obo:IAO_0000115 "Accumulation of cell free, noninflammatony fluid within the wall of the intestinal tract producing uniform thickening of the mucosal folds." ; oboInOwl:hasDbXref "UMLS:C1142262" ; oboInOwl:hasExactSynonym "Intestinal oedema" ; oboInOwl:id "HP:0005225" ; a owl:Class ; rdfs:comment "This finding can be observed upon abdominal radiography. The bowel lumen may be slightly dilated. Secondary to the fluid accumulation, there are anatomic and motor alterations in the intestine which are reflected in the roentgenogram." ; rdfs:label "Intestinal edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005227 obo:IAO_0000115 "Presence of multiple adenomatous polyps in the colon." ; oboInOwl:hasAlternativeId "HP:0005226" ; oboInOwl:hasDbXref "MEDDRA:10056981", "UMLS:C1868071" ; oboInOwl:hasExactSynonym "Multiple adenomatous colon polyps", "Multiple colonic adenomatous polyps" ; oboInOwl:id "HP:0005227" ; a owl:Class ; rdfs:label "Adenomatous colonic polyposis" ; rdfs:subClassOf obo:HP_0030255, obo:HP_0100273 . obo:HP_0005229 oboInOwl:hasDbXref "UMLS:C4025232" ; oboInOwl:id "HP:0005229" ; a owl:Class ; rdfs:label "Jejunoileal ulceration" ; rdfs:subClassOf obo:HP_0001549, obo:HP_0005265, obo:HP_0034274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_579 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005230 obo:IAO_0000115 "Obstruction affecting the biliary tree." ; oboInOwl:hasDbXref "SNOMEDCT_US:235918000", "UMLS:C0400979" ; oboInOwl:id "HP:0005230" ; a owl:Class ; rdfs:label "Biliary tract obstruction" ; rdfs:subClassOf obo:HP_0012440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005231 obo:IAO_0000115 "A chronic form of gastritis." ; oboInOwl:hasDbXref "SNOMEDCT_US:8493009", "UMLS:C0085695" ; oboInOwl:id "HP:0005231" ; a owl:Class ; rdfs:label "Chronic gastritis" ; rdfs:subClassOf obo:HP_0005263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005232 obo:IAO_0000115 "The presence of developmental dysplasia of the pancreas." ; oboInOwl:hasDbXref "UMLS:C4019084" ; oboInOwl:id "HP:0005232" ; a owl:Class ; rdfs:comment "Dysplasia is defined in MPATH as a distortion or deficiency of the tissue or cellular architecture." ; rdfs:label "Pancreatic dysplasia" ; rdfs:subClassOf obo:HP_0012090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005233 obo:IAO_0000115 "The presence of a hypoplastic gallbladder." ; oboInOwl:hasDbXref "SNOMEDCT_US:93259002", "UMLS:C0345282" ; oboInOwl:hasExactSynonym "Hypoplastic gallbladder" ; oboInOwl:id "HP:0005233" ; a owl:Class ; rdfs:label "Hypoplasia of the gallbladder" ; rdfs:subClassOf obo:HP_0011466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005234 oboInOwl:hasDbXref "UMLS:C0859974" ; oboInOwl:id "HP:0005234" ; a owl:Class ; rdfs:label "Neonatal intestinal obstruction" ; rdfs:subClassOf obo:HP_0005214 . obo:HP_0005235 obo:IAO_0000115 "A developmental defect resulting in abnormal closure, or atresia of the tubular structure of the jejunum." ; oboInOwl:hasAlternativeId "HP:0011101" ; oboInOwl:hasDbXref "MSH:D007409", "SNOMEDCT_US:204702007", "SNOMEDCT_US:360491009", "UMLS:C0266175" ; oboInOwl:id "HP:0005235" ; a owl:Class ; rdfs:label "Jejunal atresia" ; rdfs:subClassOf obo:HP_0005265, obo:HP_0011100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005236 obo:IAO_0000115 "A form of chronic pancreatitis that is characterized by calcification." ; oboInOwl:hasDbXref "UMLS:C4025231" ; oboInOwl:id "HP:0005236" ; a owl:Class ; rdfs:label "Chronic calcifying pancreatitis" ; rdfs:subClassOf obo:HP_0001733 . obo:HP_0005237 obo:IAO_0000115 "The presence of degenerative changes of the liver." ; oboInOwl:hasDbXref "UMLS:C4025230" ; oboInOwl:id "HP:0005237" ; a owl:Class ; rdfs:label "Degenerative liver disease" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005238 oboInOwl:hasDbXref "UMLS:C4025229" ; oboInOwl:id "HP:0005238" ; a owl:Class ; rdfs:label "Discrete intestinal polyps" ; rdfs:subClassOf obo:HP_0200008 . obo:HP_0005240 oboInOwl:hasDbXref "SNOMEDCT_US:405247003", "UMLS:C0239296" ; oboInOwl:id "HP:0005240" ; a owl:Class ; rdfs:label "Esophageal obstruction" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0004796 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005241 obo:IAO_0000115 "A congenital defect characterized by the lack of ganglion cells in the entire intestine, i.e., the aganglionic segment comprises the entire large and small bowel." ; oboInOwl:hasDbXref "MSH:C538058", "SNOMEDCT_US:204745000", "UMLS:C0345240" ; oboInOwl:id "HP:0005241" ; a owl:Class ; rdfs:label "Total intestinal aganglionosis" ; rdfs:subClassOf obo:HP_0004362 . obo:HP_0005242 obo:IAO_0000115 "Atresia in the extrahepatic bile duct." ; oboInOwl:hasAlternativeId "HP:0006553" ; oboInOwl:hasDbXref "MSH:D001656", "SNOMEDCT_US:77480004", "SNOMEDCT_US:82821008", "UMLS:C0005411" ; oboInOwl:hasExactSynonym "Biliary atresia, extrahepatic" ; oboInOwl:id "HP:0005242" ; a owl:Class ; rdfs:label "Extrahepatic biliary duct atresia" ; rdfs:subClassOf obo:HP_0005912, obo:HP_0035013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005243 obo:IAO_0000115 "Failure to form of portions of the abdominal musculature." ; oboInOwl:hasDbXref "UMLS:C4025228" ; oboInOwl:id "HP:0005243" ; a owl:Class ; rdfs:label "Partial abdominal muscle agenesis" ; rdfs:subClassOf obo:HP_0010318 . obo:HP_0005244 oboInOwl:hasDbXref "UMLS:C3152231" ; oboInOwl:hasExactSynonym "Death of digestive organ tissue due to poor blood supply", "GI infarctions" ; oboInOwl:id "HP:0005244" ; a owl:Class ; rdfs:label "Gastrointestinal infarctions" ; rdfs:subClassOf obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_124 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005245 obo:IAO_0000115 "Developmental hypoplasia of the intestine." ; oboInOwl:hasDbXref "UMLS:C4021640" ; oboInOwl:hasExactSynonym "Hypoplastic intestines", "Underdeveloped instestine" ; oboInOwl:id "HP:0005245" ; a owl:Class ; rdfs:label "Intestinal hypoplasia" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005246 obo:IAO_0000115 "A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds." ; oboInOwl:hasDbXref "MSH:D005758", "SNOMEDCT_US:413219009", "SNOMEDCT_US:60002000", "UMLS:C0017155" ; oboInOwl:hasRelatedSynonym "Menetrier disease" ; oboInOwl:id "HP:0005246" ; a owl:Class ; rdfs:label "Giant hypertrophic gastritis" ; rdfs:subClassOf obo:HP_0005263 . obo:HP_0005247 obo:IAO_0000115 "Underdevelopment of the abdominal musculature." ; oboInOwl:hasDbXref "UMLS:C3279407" ; oboInOwl:hasExactSynonym "Abdominal muscular hypoplasia" ; oboInOwl:id "HP:0005247" ; a owl:Class ; rdfs:label "Hypoplasia of the abdominal wall musculature" ; rdfs:subClassOf obo:HP_0010318 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002378 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005248 obo:IAO_0000115 "Atresia in the intrahepatic bile duct." ; oboInOwl:hasDbXref "UMLS:C1855284" ; oboInOwl:hasExactSynonym "Bile duct paucity", "Intrahepatic atresia of biliary duct" ; oboInOwl:id "HP:0005248" ; a owl:Class ; rdfs:label "Intrahepatic biliary atresia" ; rdfs:subClassOf obo:HP_0005912, obo:HP_0011040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003704 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005249 oboInOwl:hasDbXref "UMLS:C3639956" ; oboInOwl:id "HP:0005249" ; a owl:Class ; rdfs:label "Functional intestinal obstruction" ; rdfs:subClassOf obo:HP_0004796 . obo:HP_0005250 oboInOwl:hasDbXref "UMLS:C4025227" ; oboInOwl:id "HP:0005250" ; a owl:Class ; rdfs:label "High intestinal obstruction" ; rdfs:subClassOf obo:HP_0005214 . obo:HP_0005253 oboInOwl:hasDbXref "UMLS:C1848760" ; oboInOwl:hasExactSynonym "Increased anterioposterior diameter of chest" ; oboInOwl:id "HP:0005253" ; a owl:Class ; rdfs:label "Increased anterioposterior diameter of thorax" ; rdfs:subClassOf obo:HP_0100625 . obo:HP_0005254 oboInOwl:hasDbXref "UMLS:C1845576" ; oboInOwl:hasExactSynonym "Small chest on one side", "Underdeveloped chest on one side" ; oboInOwl:id "HP:0005254" ; a owl:Class ; rdfs:label "Unilateral chest hypoplasia" ; rdfs:subClassOf obo:HP_0005257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016416 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0005255 obo:IAO_0000115 "Aplasia (congenital absence) of the pectoralis minor." ; oboInOwl:hasDbXref "UMLS:C1868158" ; oboInOwl:hasExactSynonym "Pectoralis minor aplasia" ; oboInOwl:id "HP:0005255" ; a owl:Class ; rdfs:label "Absence of pectoralis minor muscle" ; rdfs:subClassOf obo:HP_0011957 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005256 obo:IAO_0000115 "Aplasia (congenital absence) of the pectoralis minor on only one side of the chest." ; oboInOwl:hasDbXref "UMLS:C4021639" ; oboInOwl:hasExactSynonym "Unilateral aplasia of pectoralis major muscle" ; oboInOwl:id "HP:0005256" ; a owl:Class ; rdfs:label "Unilateral absence of pectoralis major muscle" ; rdfs:subClassOf obo:HP_0011957 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0005257 oboInOwl:hasAlternativeId "HP:0001590" ; oboInOwl:hasDbXref "UMLS:C1837482" ; oboInOwl:hasExactSynonym "Small chest", "Small thorax" ; oboInOwl:id "HP:0005257" ; a owl:Class ; rdfs:label "Thoracic hypoplasia" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005258 oboInOwl:hasDbXref "UMLS:C4025226" ; oboInOwl:hasExactSynonym "Small/absent pec muscle", "Underdeveloped/absent pec muscle" ; oboInOwl:id "HP:0005258" ; a owl:Class ; rdfs:label "Pectoral muscle hypoplasia/aplasia" ; rdfs:subClassOf obo:HP_0001435 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005259 obo:IAO_0000115 "Increased range of shoulder movement related to aplasia or hypoplasia of the clavicles that results in the ability to approximate the shoulders in front of the chest." ; oboInOwl:hasDbXref "UMLS:C1861517" ; oboInOwl:id "HP:0005259" ; a owl:Class ; rdfs:comment "This feature is characteristic of cleidocranial dysplasia. See Figure 2 of PMID:23289840" ; rdfs:label "Abnormal facility in opposing the shoulders" ; rdfs:subClassOf obo:HP_0001547 . obo:HP_0005261 obo:IAO_0000115 "Hemorrhage occurring within a joint." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:27:00Z" ; oboInOwl:hasAlternativeId "HP:0001391", "HP:0005196" ; oboInOwl:hasDbXref "MSH:D006395", "SNOMEDCT_US:81808003", "UMLS:C0018924" ; oboInOwl:hasExactSynonym "Bleeding within a joint", "Hemarthroses", "Hemarthrosis", "Joint haemorrhage", "Spontaneous joint haemorrhage", "Spontaneous joint hemorrhage" ; oboInOwl:id "HP:0005261" ; a owl:Class ; rdfs:label "Joint hemorrhage" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0011029 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000982 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005262 obo:IAO_0000115 "Any structural anomaly of the synovium, which is a membrane that lines the cavity of synovial joints and consists of a lining layer of macrophage-like synoviocytes and fibroblast-like synoviocytes, as well as a sublining of connective tissue. Synovial cells are thought to contribute to joint homeostasis by secreting various factors such as hyaluronic acid and lubricin important for joint lubrication and function, as well as disposing of the waste products." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:27:00Z" ; oboInOwl:hasDbXref "UMLS:C4025225" ; oboInOwl:id "HP:0005262" ; a owl:Class ; rdfs:label "Abnormal synovial membrane morphology" ; rdfs:subClassOf obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007617 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005263 obo:IAO_0000115 "The presence of inflammation of the gastric mucous membrane." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:32:00Z" ; oboInOwl:hasDbXref "MEDDRA:10017853", "MSH:D005756", "SNOMEDCT_US:4556007", "UMLS:C0017152" ; oboInOwl:hasExactSynonym "Stomach inflammation" ; oboInOwl:id "HP:0005263" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Gastritis" ; rdfs:subClassOf obo:HP_0004295 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005264 obo:IAO_0000115 "An abnormality of the gallbladder." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:40:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253803008", "SNOMEDCT_US:49714001", "UMLS:C0266249" ; oboInOwl:hasExactSynonym "Abnormality of the gallbladder", "Anomaly of the gallbladder" ; oboInOwl:id "HP:0005264" ; a owl:Class ; rdfs:label "Abnormality of the gallbladder" ; rdfs:subClassOf obo:HP_0004297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005265 obo:IAO_0000115 "An abnormality of the jejunum, i.e., of the middle section of the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4025224" ; oboInOwl:hasExactSynonym "Abnormality of the jejunum" ; oboInOwl:id "HP:0005265" ; a owl:Class ; rdfs:label "Abnormal jejunum morphology" ; rdfs:subClassOf obo:HP_0002244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005266 obo:IAO_0000115 "A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T04:46:00Z" ; oboInOwl:hasDbXref "MSH:D007417", "SNOMEDCT_US:254588001", "UMLS:C0021846" ; oboInOwl:hasRelatedSynonym "Intestinal polyps" ; oboInOwl:id "HP:0005266" ; a owl:Class ; rdfs:label "Intestinal polyp" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0007378 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005267 oboInOwl:hasDbXref "UMLS:C1851808" ; oboInOwl:id "HP:0005267" ; a owl:Class ; rdfs:label "Premature delivery because of cervical insufficiency or membrane fragility" ; rdfs:subClassOf obo:HP_0001622 . obo:HP_0005268 obo:IAO_0000115 "A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy." ; oboInOwl:hasDbXref "MSH:D000022", "SNOMEDCT_US:17369002", "UMLS:C0000786" ; oboInOwl:hasExactSynonym "Early fetal demise", "Early foetal demise", "Spontaneous abortion" ; oboInOwl:id "HP:0005268" ; a owl:Class ; rdfs:comment "The age at which fetal demise is legally classified asa a miscarriage varies between countries with the US being 20 gestational weeks and the UK being 24 gestational weeks. The HPO chooses the average of these age ranges." ; rdfs:label "Miscarriage" ; rdfs:subClassOf obo:HP_0034241 . obo:HP_0005272 obo:IAO_0000115 "Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure)." ; oboInOwl:hasDbXref "UMLS:C1866487" ; oboInOwl:hasExactSynonym "Deep laugh lines", "Deep nasolabial crease", "Deep nasolabial fold", "Deep nasolabial groove", "Deep smile lines", "Nasolabial crease, prominent", "Prominent laugh lines", "Prominent nasolabial groove", "Prominent smile lines" ; oboInOwl:id "HP:0005272" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent nasolabial fold" ; rdfs:subClassOf obo:HP_0005289 . obo:HP_0005273 obo:IAO_0000115 "Lack of the cartilage of the nasal septum." ; oboInOwl:hasDbXref "UMLS:C4021638", "UMLS:C4280501" ; oboInOwl:hasExactSynonym "Absent nasal septal cartilage", "Absent nasal septum", "Ageneis of nasal septal cartilage" ; oboInOwl:hasNarrowSynonym "Failure of development of nasal septal cartilage" ; oboInOwl:id "HP:0005273" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent nasal septal cartilage" ; rdfs:subClassOf obo:HP_0009935, obo:HP_3000034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005274 oboInOwl:hasDbXref "UMLS:C1856118", "UMLS:C4280498", "UMLS:C4280499", "UMLS:C4280500" ; oboInOwl:hasExactSynonym "Large nasal tip", "Large tip of nose", "Prominent nasal tip", "Prominent tip of nose", "Pronounced nasal tip", "Pronounced tip of nose" ; oboInOwl:hasNarrowSynonym "Bulbous tip of nose" ; oboInOwl:hasRelatedSynonym "Hyperplasia of nasal tip", "Hyperplasia of tip of nose", "Hypertrophy of nasal tip", "Hypertrophy of tip of nose" ; oboInOwl:id "HP:0005274" ; a owl:Class ; rdfs:label "Prominent nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005275 oboInOwl:hasDbXref "UMLS:C1855616" ; oboInOwl:hasExactSynonym "Cartilaginous nasal ossification" ; oboInOwl:id "HP:0005275" ; a owl:Class ; rdfs:label "Cartilaginous ossification of nose" ; rdfs:subClassOf obo:HP_0000429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0006906 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005278 oboInOwl:hasDbXref "UMLS:C1844731", "UMLS:C4280496", "UMLS:C4280497" ; oboInOwl:hasExactSynonym "Decreased size of nasal tip", "Decreased size of tip of nose", "Hypoplasia of tip of nose", "Small nasal tip", "Small tip of nose", "Underdevelopment of nasal tip", "Underdevelopment of tip of nose" ; oboInOwl:hasNarrowSynonym "Aplasia of nasal tip" ; oboInOwl:hasRelatedSynonym "Deficient nasal tip", "Hypotrophic nasal tip", "Hypotrophic tip of nose" ; oboInOwl:id "HP:0005278" ; a owl:Class ; rdfs:label "Hypoplastic nasal tip" ; rdfs:subClassOf obo:HP_0000436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005280 obo:IAO_0000115 "Posterior positioning of the nasal root in relation to the overall facial profile for age." ; oboInOwl:hasAlternativeId "HP:0000425", "HP:0000428", "HP:0000439", "HP:0000459", "HP:0004413", "HP:0004505", "HP:0004506", "HP:0004666", "HP:0005119", "HP:0005284" ; oboInOwl:hasDbXref "UMLS:C1836542", "UMLS:C3550546", "UMLS:C4280495" ; oboInOwl:hasExactSynonym "Depressed bridge of nose", "Depressed nasal bridge", "Depressed nasal root", "Flat bridge of nose", "Flat nasal bridge", "Flat nasal root", "Flat, nasal bridge", "Flattened nasal bridge", "Low nasal bridge", "Low nasal root", "Retruded bridge of nose", "Retruded nasal bridge" ; oboInOwl:hasRelatedSynonym "Concave bridge of nose", "Concave nasal bridge", "Depressed nasal root/bridge" ; oboInOwl:id "HP:0005280" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The adjective \"depressed\" here does not indicate an active process but a status. A depressed nasal bridge can occur irrespective of the width of the nasal bridge, and the width should be assessed independently. In infancy, the nasal bridge is relatively more posterior than in the older person. The term depressed nasal bridge should only be used when the bridge is more posterior than is typical for age and ethnic background." ; rdfs:label "Depressed nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005281 oboInOwl:hasDbXref "UMLS:C1865597", "UMLS:C4280494" ; oboInOwl:hasExactSynonym "Decreased size of bridge of nose", "Decreased size of nasal bridge", "Hypoplastic bridge of nose", "Small bridge of nose", "Small nasal bridge" ; oboInOwl:hasRelatedSynonym "Hypotrophic bridge of nose", "Hypotrophic nasal bridge" ; oboInOwl:id "HP:0005281" ; a owl:Class ; rdfs:label "Hypoplastic nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005285 oboInOwl:hasDbXref "UMLS:C1837888" ; oboInOwl:hasExactSynonym "Absent bridge of nose", "Absent nasal bridge", "Agenesis of bridge of nose", "Agenesis of nasal bridge", "Missing bridge of nose", "Missing nasal bridge" ; oboInOwl:id "HP:0005285" ; a owl:Class ; rdfs:label "Absent nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008340 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005288 obo:IAO_0000115 "Abnormality of the nostril." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T06:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4021637" ; oboInOwl:hasExactSynonym "Abnormal naris morphology", "Abnormality of the nares", "Abnormality of the nostrils", "Anomaly of the nares" ; oboInOwl:hasNarrowSynonym "Deformity of the nares", "Deformity of the nostrils", "Malformation of the nares", "Malformation of the nostrils" ; oboInOwl:id "HP:0005288" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal nostril morphology" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005289 dcterms:creator ; oboInOwl:creation_date "2008-03-26T06:07:00Z" ; oboInOwl:hasDbXref "UMLS:C4025223" ; oboInOwl:hasExactSynonym "Anomaly of the nasolabial region" ; oboInOwl:hasNarrowSynonym "Deformity of the nasolabial region", "Malformation of the nasolabial region" ; oboInOwl:id "HP:0005289" ; a owl:Class ; rdfs:label "Abnormality of the nasolabial region" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005290 oboInOwl:hasDbXref "UMLS:C1855736", "UMLS:C4280491", "UMLS:C4280492", "UMLS:C4280493" ; oboInOwl:hasExactSynonym "Decreased size of internal carotid artery", "Small internal carotid artery" ; oboInOwl:hasNarrowSynonym "Aplasia of internal carotid artery" ; oboInOwl:hasRelatedSynonym "Deficiency of internal carotid artery", "Hypotrophic internal carotid artery" ; oboInOwl:id "HP:0005290" ; a owl:Class ; rdfs:label "Internal carotid artery hypoplasia" ; rdfs:subClassOf obo:HP_3000062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001532 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005291 oboInOwl:hasDbXref "UMLS:C4025222" ; oboInOwl:id "HP:0005291" ; a owl:Class ; rdfs:label "Inflammatory arteriopathy" ; rdfs:subClassOf obo:HP_0034785 . obo:HP_0005292 oboInOwl:hasDbXref "UMLS:C1968633" ; oboInOwl:id "HP:0005292" ; a owl:Class ; rdfs:label "Intimal thickening in the coronary arteries" ; rdfs:subClassOf obo:HP_0006704 . obo:HP_0005293 oboInOwl:hasDbXref "MSH:D014689", "SNOMEDCT_US:20696009", "UMLS:C0042485" ; oboInOwl:hasExactSynonym "Poorly functioning veins" ; oboInOwl:id "HP:0005293" ; a owl:Class ; rdfs:label "Venous insufficiency" ; rdfs:subClassOf obo:HP_0002624 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005294 obo:IAO_0000115 "A separation (dissection) of the layers of an artery." ; oboInOwl:hasDbXref "MSH:D000784", "SNOMEDCT_US:233992003", "SNOMEDCT_US:26845001", "SNOMEDCT_US:710864009", "SNOMEDCT_US:9406001", "UMLS:C0002949" ; oboInOwl:id "HP:0005294" ; a owl:Class ; rdfs:label "Arterial dissection" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0005295 obo:IAO_0000115 "Pseudocoarctation is a congenital anomaly of kinking, or buckling, of the aorta without a pressure gradient across the lesion. It is characterized by elongation and kinking of the aorta at the level of the ligamentum arteriosum." ; oboInOwl:hasDbXref "SNOMEDCT_US:70602002", "UMLS:C0345088" ; oboInOwl:id "HP:0005295" ; a owl:Class ; rdfs:comment "Note that the ligamentum arteriosum, which develops from the ductus arteriosus, is attached to the superior surface of the pulmonary artery and the inferior surface of the aortic arch." ; rdfs:label "Pseudocoarctation of the aorta" ; rdfs:subClassOf obo:HP_0012303 . obo:HP_0005296 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0005296" ; a owl:Class ; rdfs:label "obsolete Occlusive vascular disease" ; owl:deprecated true . obo:HP_0005297 obo:IAO_0000115 "Peripheral arterial stenosis with onset before the age of 50 years." ; oboInOwl:hasDbXref "UMLS:C1867457" ; oboInOwl:id "HP:0005297" ; a owl:Class ; rdfs:label "Premature occlusive vascular stenosis" ; rdfs:subClassOf obo:HP_0004950 . obo:HP_0005298 obo:IAO_0100001 "HP:0006695" ; oboInOwl:id "HP:0005298" ; a owl:Class ; rdfs:label "obsolete Atrioventricular canal defect with right ventricle aorta and pulmonary atresia" ; owl:deprecated true . obo:HP_0005299 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0005299" ; a owl:Class ; rdfs:label "obsolete Premature peripheral vascular disease" ; owl:deprecated true . obo:HP_0005300 oboInOwl:hasDbXref "UMLS:C4025219" ; oboInOwl:id "HP:0005300" ; a owl:Class ; rdfs:label "Nodular inflammatory vasculitis" ; rdfs:subClassOf obo:HP_0034785 . obo:HP_0005301 obo:IAO_0000115 "A rare congenital vascular anomaly that results when the left superior cardinal vein caudal to the innominate vein fails to regress." ; oboInOwl:hasDbXref "SNOMEDCT_US:77978002", "UMLS:C0265931" ; oboInOwl:hasExactSynonym "PLSVC" ; oboInOwl:id "HP:0005301" ; a owl:Class ; rdfs:label "Persistent left superior vena cava" ; rdfs:subClassOf obo:HP_0025575 . obo:HP_0005302 obo:IAO_0000115 "Abnormal tortuous (i.e., twisted) form of the carotid arteries." ; oboInOwl:hasDbXref "SNOMEDCT_US:401051003", "UMLS:C1303076" ; oboInOwl:hasExactSynonym "Tortuous carotid arteries" ; oboInOwl:id "HP:0005302" ; a owl:Class ; rdfs:label "Carotid artery tortuosity" ; rdfs:subClassOf obo:HP_0005116, obo:HP_0005344 . obo:HP_0005303 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the arch of aorta." ; oboInOwl:hasDbXref "UMLS:C1969291" ; oboInOwl:id "HP:0005303" ; a owl:Class ; rdfs:label "Aortic arch calcification" ; rdfs:subClassOf obo:HP_0004962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001508 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005304 oboInOwl:hasDbXref "UMLS:C1970501" ; oboInOwl:hasExactSynonym "Underdeveloped lung veins" ; oboInOwl:id "HP:0005304" ; a owl:Class ; rdfs:label "Hypoplastic pulmonary veins" ; rdfs:subClassOf obo:HP_0030968 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005305 obo:IAO_0000115 "Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow." ; oboInOwl:hasDbXref "SNOMEDCT_US:95455008", "UMLS:C0151945" ; oboInOwl:hasExactSynonym "Blood clot in cerebral vein", "Cerebral thrombosis", "Cerebral vein thrombosis" ; oboInOwl:id "HP:0005305" ; a owl:Class ; rdfs:label "Cerebral venous thrombosis" ; rdfs:subClassOf obo:HP_0004936 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001663 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005306 obo:IAO_0000115 "The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces." ; oboInOwl:hasDbXref "MSH:D018324", "SNOMEDCT_US:195382003", "SNOMEDCT_US:254206003", "SNOMEDCT_US:402867006", "SNOMEDCT_US:56975005", "SNOMEDCT_US:83343001", "UMLS:C0206733" ; oboInOwl:hasExactSynonym "Capillary hemangiomata", "Strawberry birthmark" ; oboInOwl:id "HP:0005306" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Capillary hemangioma" ; rdfs:subClassOf obo:HP_0001028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001028 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005307 oboInOwl:hasDbXref "UMLS:C1850438" ; oboInOwl:id "HP:0005307" ; a owl:Class ; rdfs:label "Postural hypotension with compensatory tachycardia" ; rdfs:subClassOf obo:HP_0001278 . obo:HP_0005308 oboInOwl:hasDbXref "UMLS:C1867424" ; oboInOwl:id "HP:0005308" ; a owl:Class ; rdfs:label "Pulmonary artery vasoconstriction" ; rdfs:subClassOf obo:HP_0030967 . obo:HP_0005309 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0005309" ; a owl:Class ; rdfs:label "obsolete Peripheral vascular insufficiency" ; owl:deprecated true . obo:HP_0005310 obo:IAO_0000115 "A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta." ; oboInOwl:hasDbXref "UMLS:C4025218" ; oboInOwl:id "HP:0005310" ; a owl:Class ; rdfs:label "Large vessel vasculitis" ; rdfs:subClassOf obo:HP_0034784 . obo:HP_0005311 obo:IAO_0000115 "A developmental defect characterized by the lack of formation of the pulmonary blood vessels." ; oboInOwl:hasDbXref "UMLS:C1970630" ; oboInOwl:hasExactSynonym "Absent lung vessels" ; oboInOwl:id "HP:0005311" ; a owl:Class ; rdfs:label "Agenesis of pulmonary vessels" ; rdfs:subClassOf obo:HP_0004930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000102 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005312 obo:IAO_0000115 "Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries in the pulmonary circulation." ; oboInOwl:hasDbXref "UMLS:C4025217" ; oboInOwl:id "HP:0005312" ; a owl:Class ; rdfs:comment "Some causes of intimal fibrosis are hypertension, intimal fibroplasia, arterial atheroma, and CADASIL syndrome." ; rdfs:label "Pulmonary aterial intimal fibrosis" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0005313 obo:IAO_0000115 "An arterial lesion that is characterized by either intimal fibroplasia, with neointimal lesions of cells and matrix deposition, or medial fibroplasia, in which there is loss of smooth muscle cells and increased deposition of collagen and proteoglycans in the medial layer." ; oboInOwl:hasDbXref "MSH:D005352", "SNOMEDCT_US:31653004", "SNOMEDCT_US:359553002", "UMLS:C0016052" ; oboInOwl:id "HP:0005313" ; a owl:Class ; rdfs:comment "Fibromuscular dysplasia (FMD) is distinct from atherosclerotic lesions in that FMD lesions do not contain inflammatory cells or lipids. Instead, the pathology of FMD. FMD can result in arterial stenosis or occlusion, and less commonly, arterial dissection or aneurysm formation. FMD can affect almost any artery but most commonly affects the renal arteries, presenting as hypertension, and the carotid and vertebral arteries, leading to ischemic stroke, transient ischemic attacks, headaches, and pulsatile tinnitus." ; rdfs:label "Arterial fibromuscular dysplasia" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0005314 oboInOwl:hasDbXref "UMLS:C1847886" ; oboInOwl:id "HP:0005314" ; a owl:Class ; rdfs:label "Anomalous branches of internal carotid artery" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0005315 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0005315" ; a owl:Class ; rdfs:label "obsolete Peripheral artery occlusive disease" ; owl:deprecated true . obo:HP_0005316 oboInOwl:hasDbXref "UMLS:C1848877" ; oboInOwl:id "HP:0005316" ; a owl:Class ; rdfs:label "Peripheral pulmonary vessel aplasia" ; rdfs:subClassOf obo:HP_0004930 . obo:HP_0005317 obo:IAO_0000115 "Pulmonary vascular resistance (PVR) more than 3 wood units, as defined by the current definition of pulmonary hypertension. 95% of individuals have a PVR of less than 2.4 wood units." ; oboInOwl:hasDbXref "UMLS:C1867423" ; oboInOwl:id "HP:0005317" ; a owl:Class ; rdfs:label "Increased pulmonary vascular resistance" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0005318 obo:IAO_0000115 "Inflammation of the blood vessels within the brain." ; oboInOwl:hasDbXref "MSH:D020293", "SNOMEDCT_US:427020007", "UMLS:C0238051" ; oboInOwl:id "HP:0005318" ; a owl:Class ; rdfs:label "Cerebral vasculitis" ; rdfs:subClassOf obo:HP_0034784, obo:HP_0100659 . obo:HP_0005320 oboInOwl:hasDbXref "UMLS:C3277426" ; oboInOwl:hasExactSynonym "Lack of facial fat below the skin" ; oboInOwl:id "HP:0005320" ; a owl:Class ; rdfs:label "Lack of facial subcutaneous fat" ; rdfs:subClassOf obo:HP_0003717 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005321 obo:IAO_0000115 "A type of craniofacial dysostosis associated with abnormalities of the external ears, mirognathia, macrostomia, coloboma of the lower eyelid, and cleft palate. This is a bundled term that is left in the HPO now for convenience with legacy annotations but should not be used for new annotations." ; oboInOwl:hasDbXref "MSH:D008342", "SNOMEDCT_US:82203000", "UMLS:C0242387" ; oboInOwl:hasExactSynonym "Treacher Collins syndrome" ; oboInOwl:id "HP:0005321" ; a owl:Class ; rdfs:label "Mandibulofacial dysostosis" ; rdfs:subClassOf obo:HP_0004439 . obo:HP_0005322 oboInOwl:hasDbXref "UMLS:C4025216", "UMLS:C4280489", "UMLS:C4280490" ; oboInOwl:hasExactSynonym "Prominent nasal septum", "Prominent septum of nose" ; oboInOwl:hasNarrowSynonym "Low hanging nasal septum", "Low hanging septum of nose", "Visible nasal septum", "Visible septum of nose" ; oboInOwl:id "HP:0005322" ; a owl:Class ; rdfs:label "Prominent nasal septum" ; rdfs:subClassOf obo:HP_0000419 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005323 obo:IAO_0000115 "Unilateral overgrowth of facial tissues, including muscles, bones and skin." ; oboInOwl:hasDbXref "MSH:C563014", "MSH:D005621", "SNOMEDCT_US:10394003", "SNOMEDCT_US:697962004", "UMLS:C0016719", "UMLS:C1399354" ; oboInOwl:hasExactSynonym "Enlargement of half of face", "Facial hemihypertophy", "Hemifacial enlargement", "Hypertrophy of half of face", "Increase in size of half of face", "Overgrowth of half of face" ; oboInOwl:hasRelatedSynonym "Facial hemihyperplasia", "Friedreich's disease" ; oboInOwl:id "HP:0005323" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hemifacial hypertrophy" ; rdfs:subClassOf obo:HP_0000324 . obo:HP_0005324 obo:IAO_0000115 "An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed." ; oboInOwl:hasDbXref "UMLS:C4025215" ; oboInOwl:hasExactSynonym "Disturbance of facial expression" ; oboInOwl:id "HP:0005324" ; a owl:Class ; rdfs:label "Disturbance of facial expression" ; rdfs:subClassOf obo:HP_0005346 . obo:HP_0005325 obo:IAO_0000115 "A pattern of hair growth in which there is hair extending from the temples to the lateral eyebrows." ; oboInOwl:hasDbXref "UMLS:C1857455" ; oboInOwl:hasExactSynonym "Unusual hairline with hair growth on temples extending to lateral eyebrow" ; oboInOwl:id "HP:0005325" ; a owl:Class ; rdfs:label "Extension of hair growth on temples to lateral eyebrow" ; rdfs:subClassOf obo:HP_0000599 . obo:HP_0005326 obo:IAO_0000115 "Underdevelopment of the philtrum." ; oboInOwl:hasAlternativeId "HP:0005331" ; oboInOwl:hasDbXref "UMLS:C1856886" ; oboInOwl:hasExactSynonym "Small philtrum" ; oboInOwl:id "HP:0005326" ; a owl:Class ; rdfs:label "Hypoplastic philtrum" ; rdfs:subClassOf obo:HP_0000288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005327 oboInOwl:hasDbXref "UMLS:C1852476" ; oboInOwl:hasExactSynonym "Loss of facial expression" ; oboInOwl:id "HP:0005327" ; a owl:Class ; rdfs:label "Loss of facial expression" ; rdfs:subClassOf obo:HP_0004673 . obo:HP_0005328 obo:IAO_0000115 "A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance." ; oboInOwl:hasAlternativeId "HP:0000335", "HP:0005333" ; oboInOwl:hasDbXref "UMLS:C1857710" ; oboInOwl:hasExactSynonym "Aged facial appearance", "Premature aged appearance", "Prematurely aged face", "Prematurely aged facial appearance", "Wizened face" ; oboInOwl:id "HP:0005328" ; a owl:Class ; rdfs:label "Progeroid facial appearance" ; rdfs:subClassOf obo:HP_0007495 . obo:HP_0005329 oboInOwl:hasDbXref "UMLS:C1855353" ; oboInOwl:hasExactSynonym "Fixed facial expression", "Unchanging facial expression" ; oboInOwl:id "HP:0005329" ; a owl:Class ; rdfs:label "Fixed facial expression" ; rdfs:subClassOf obo:HP_0004673 . obo:HP_0005332 obo:IAO_0000115 "Recurrent partial dislocations of the mandible." ; oboInOwl:hasDbXref "UMLS:C1857011" ; oboInOwl:id "HP:0005332" ; a owl:Class ; rdfs:label "Recurrent mandibular subluxations" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0032153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005335 oboInOwl:hasDbXref "UMLS:C4025214" ; oboInOwl:hasExactSynonym "Sleepy facial expression", "Somnolent facial expression" ; oboInOwl:id "HP:0005335" ; a owl:Class ; rdfs:label "Sleepy facial expression" ; rdfs:subClassOf obo:HP_0005324 . obo:HP_0005336 oboInOwl:hasDbXref "UMLS:C1969673" ; oboInOwl:hasExactSynonym "Darkening of the forehead" ; oboInOwl:id "HP:0005336" ; a owl:Class ; rdfs:label "Forehead hyperpigmentation" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0007400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0016475 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005338 obo:IAO_0000115 "Decreased density/number and/or decreased diameter of lateral eyebrow hairs." ; oboInOwl:hasAlternativeId "HP:0004521", "HP:0009923" ; oboInOwl:hasDbXref "UMLS:C1857206" ; oboInOwl:hasExactSynonym "Lateral hypoplasia of eyebrows", "Lateral thinning of eyebrows", "Laterally sparse eyebrow", "Laterally sparse eyebrows", "Limited hair on end of eyebrow" ; oboInOwl:hasRelatedSynonym "Sparse lateral eyebrows" ; oboInOwl:id "HP:0005338" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Abnormal sparseness of the eyebrows laterally." ; rdfs:label "Sparse lateral eyebrow" ; rdfs:subClassOf obo:HP_0045075 . obo:HP_0005339 obo:IAO_0000115 "An abnormality of the complement system." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T07:58:00Z" ; oboInOwl:hasAlternativeId "HP:0025541" ; oboInOwl:hasDbXref "UMLS:C4025213" ; oboInOwl:id "HP:0005339" ; a owl:Class ; rdfs:comment "The complement system represents a family of over 25 serum proteins and cell surface receptors that act in a cascade manner leading to innate functions such as inflammation and enhancement of adaptive immunity. Three general pathways, i.e. classical, lectin and alternative, activate the complement system." ; rdfs:label "Abnormality of complement system" ; rdfs:subClassOf obo:HP_0005368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0006956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005340 oboInOwl:hasDbXref "UMLS:C1836904" ; oboInOwl:id "HP:0005340" ; a owl:Class ; rdfs:label "Spastic/hyperactive bladder" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0005341 obo:IAO_0000115 "Abnormal bladder function (increased urge or frequency of urination or urge incontinence) resulting from abnormal functioning of the autonomic nervous system." ; oboInOwl:hasDbXref "UMLS:C4025212" ; oboInOwl:id "HP:0005341" ; a owl:Class ; rdfs:label "Autonomic bladder dysfunction" ; rdfs:subClassOf obo:HP_0012332 . obo:HP_0005343 obo:IAO_0000115 "Underdevelopment of the urinary bladder." ; oboInOwl:hasAlternativeId "HP:0005342" ; oboInOwl:hasDbXref "UMLS:C1855335" ; oboInOwl:hasExactSynonym "Hypoplastic bladder", "Underdeveloped bladder" ; oboInOwl:id "HP:0005343" ; a owl:Class ; rdfs:label "Hypoplasia of the bladder" ; rdfs:subClassOf obo:HP_0010476 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005344 obo:IAO_0000115 "Any structural abnormality of the carotid arteries, including the common carotid artery and its' arterial branches." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T06:37:00Z" ; oboInOwl:hasDbXref "UMLS:C4025211" ; oboInOwl:hasExactSynonym "Abnormality of the carotid arteries" ; oboInOwl:id "HP:0005344" ; a owl:Class ; rdfs:label "Abnormal carotid artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001530 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005345 obo:IAO_0000115 "An abnormality of the structure of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T06:40:00Z" ; oboInOwl:hasAlternativeId "HP:0030971" ; oboInOwl:hasDbXref "UMLS:C4025210" ; oboInOwl:hasRelatedSynonym "Abnormality of the vena cava" ; oboInOwl:id "HP:0005345" ; a owl:Class ; rdfs:label "Abnormal vena cava morphology" ; rdfs:subClassOf obo:HP_0002624, obo:HP_0030962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004087 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005346 dcterms:creator ; oboInOwl:creation_date "2008-03-26T06:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4025209" ; oboInOwl:hasExactSynonym "Abnormal facial expression" ; oboInOwl:id "HP:0005346" ; a owl:Class ; rdfs:label "Abnormal facial expression" ; rdfs:subClassOf obo:HP_0000271 . obo:HP_0005347 obo:IAO_0000115 """Tracheal cartilaginous sleeve (TCS) is a rare congenital airway malformation in which distinct tracheal rings are replaced by a continuous cartilaginous segment. Vertically fused C- or O-shaped cartilaginous rings can extend from the subglottis to the carina or bronchus with little to no pars membranacea posteriorly. Comment:Tracheal cartilaginous sleeve has been associated with various craniosynostosis syndromes.""" ; oboInOwl:hasDbXref "UMLS:C1863363" ; oboInOwl:id "HP:0005347" ; a owl:Class ; rdfs:label "Tracheal cartilaginous sleeve" ; rdfs:subClassOf obo:HP_0002778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001449 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005348 obo:IAO_0000115 "Inspiratory stridor is a high pitched sound upon inspiration that is generally related to laryngeal abnormalities." ; oboInOwl:hasDbXref "SNOMEDCT_US:58596002", "UMLS:C0677600" ; oboInOwl:id "HP:0005348" ; a owl:Class ; rdfs:label "Inspiratory stridor" ; rdfs:subClassOf obo:HP_0010307 . obo:HP_0005349 obo:IAO_0000115 "Hypoplasia of the epiglottis." ; oboInOwl:hasAlternativeId "HP:0008746" ; oboInOwl:hasDbXref "UMLS:C1396772" ; oboInOwl:hasExactSynonym "Hypoplastic epiglottis" ; oboInOwl:id "HP:0005349" ; a owl:Class ; rdfs:label "Hypoplasia of the epiglottis" ; rdfs:subClassOf obo:HP_0010565 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005352 obo:IAO_0000115 "A primary immune deficiency that is characterized by defects or deficiencies of T-lymphocytes that causes specific susceptibility to intracellular micro-organisms." ; oboInOwl:hasDbXref "UMLS:C4025208" ; oboInOwl:hasExactSynonym "Severe T-cell immunodeficiency" ; oboInOwl:id "HP:0005352" ; a owl:Class ; rdfs:comment "Several diseases are classified as severe T cell immunodeficiencies: severe combined immunodeficiency syndrome (SCID), reticular dysgenesis, thymic dysplasia (Nezelof syndrome), combined immunodeficiency disease (CID), and Wiskott-Aldrich syndrome (WAS)." ; rdfs:label "Severe T-cell immunodeficiency" ; rdfs:subClassOf obo:HP_0005374 . obo:HP_0005353 obo:IAO_0000115 "Increased susceptibility to herpesvirus, as manifested by recurrent episodes of herpesvirus." ; oboInOwl:hasDbXref "UMLS:C4025207" ; oboInOwl:hasExactSynonym "Susceptibility to herpesvirus" ; oboInOwl:id "HP:0005353" ; a owl:Class ; rdfs:label "Recurrent herpes" ; rdfs:subClassOf obo:HP_0034318 . obo:HP_0005354 obo:IAO_0000115 "Complete inability of T cells to perform their functions in cell-mediated immunity." ; oboInOwl:hasDbXref "UMLS:C1849426" ; oboInOwl:hasExactSynonym "Absent cellular immunity" ; oboInOwl:id "HP:0005354" ; a owl:Class ; rdfs:label "Lack of T cell function" ; rdfs:subClassOf obo:HP_0011840 . obo:HP_0005356 obo:IAO_0000115 "Concentration of the complement component factor I in the blood circulation below the lower limit of normal." ; oboInOwl:hasDbXref "UMLS:C1970257" ; oboInOwl:hasExactSynonym "Decreased serum complement factor I" ; oboInOwl:id "HP:0005356" ; a owl:Class ; rdfs:label "Decreased circulating complement factor I concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0005357 obo:IAO_0000115 "Reduced functionality of the process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." ; oboInOwl:hasDbXref "UMLS:C1859624" ; oboInOwl:id "HP:0005357" ; a owl:Class ; rdfs:label "Defective B cell differentiation" ; rdfs:subClassOf obo:HP_0005384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030183 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005359 obo:IAO_0000115 "Absence of the thymus. This feature may be appreciated by the lack of a thymic shadow upon radiographic examination." ; oboInOwl:hasDbXref "MSH:C536288", "SNOMEDCT_US:702623002", "SNOMEDCT_US:91918005", "UMLS:C0685894" ; oboInOwl:hasExactSynonym "Absent thymus", "Athymia" ; oboInOwl:hasRelatedSynonym "Absent thymic shadow", "Lack of thymic shadow" ; oboInOwl:id "HP:0005359" ; a owl:Class ; rdfs:label "Aplasia of the thymus" ; rdfs:subClassOf obo:HP_0010515 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005360 obo:IAO_0000115 "Increased susceptibility to chicken pox, as manifested by recurrent episodes of chicken pox." ; oboInOwl:hasDbXref "UMLS:C1855205" ; oboInOwl:id "HP:0005360" ; a owl:Class ; rdfs:label "Susceptibility to chickenpox" ; rdfs:subClassOf obo:HP_0004429 . obo:HP_0005363 obo:IAO_0000115 "A general term referring to a defect in immunity resulting from impaired antibody production." ; oboInOwl:hasDbXref "UMLS:C4025206" ; oboInOwl:id "HP:0005363" ; a owl:Class ; rdfs:comment "If possible it is preferable to use a precise description of the observed manifestations leading to the inference of humoral immunodeficiency." ; rdfs:label "Humoral immunodeficiency" ; rdfs:subClassOf obo:HP_0002721 . obo:HP_0005364 obo:IAO_0100001 "HP:0004429" ; oboInOwl:id "HP:0005364" ; a owl:Class ; rdfs:label "obsolete Severe viral infections" ; owl:deprecated true . obo:HP_0005365 obo:IAO_0000115 "A severe form of B lymphocytopenia in which the count of B cells is very low or absent." ; oboInOwl:hasAlternativeId "HP:0002856" ; oboInOwl:hasDbXref "UMLS:C1863715", "UMLS:C4020824" ; oboInOwl:hasExactSynonym "Absent B cells" ; oboInOwl:hasRelatedSynonym "Absence of B cells" ; oboInOwl:id "HP:0005365" ; a owl:Class ; rdfs:label "Severe B lymphocytopenia" ; rdfs:subClassOf obo:HP_0010976 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005366 obo:IAO_0000115 "Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae." ; oboInOwl:hasDbXref "UMLS:C2169794" ; oboInOwl:id "HP:0005366" ; a owl:Class ; rdfs:label "Recurrent streptococcus pneumoniae infections" ; rdfs:subClassOf obo:HP_0002205, obo:HP_0020096 . obo:HP_0005368 obo:IAO_0000115 "An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system." ; oboInOwl:hasDbXref "UMLS:C3150510" ; oboInOwl:hasExactSynonym "Defective humoral immunity" ; oboInOwl:id "HP:0005368" ; a owl:Class ; rdfs:label "Abnormality of humoral immunity" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0005369 obo:IAO_0000115 "Concentration of the complement component factor H in the blood circulation below the lower limit of normal." ; oboInOwl:hasDbXref "UMLS:C1969222" ; oboInOwl:hasExactSynonym "Decreased serum complement factor H" ; oboInOwl:id "HP:0005369" ; a owl:Class ; rdfs:label "Decreased circulating complement factor H concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0005372 obo:IAO_0000115 "An abnormality of the physiological functioning of B cells." ; oboInOwl:hasAlternativeId "HP:0005398" ; oboInOwl:hasDbXref "UMLS:C1849242" ; oboInOwl:hasExactSynonym "Abnormality of B cell physiology", "Reduced B cell function" ; oboInOwl:id "HP:0005372" ; a owl:Class ; rdfs:comment "This term refers to any abnormality of the B cells, which play a role in the humoral immune response. The main functions of B cells are to produce antibodies, to perform the role of antigen presenting cells, and to develop into memory cells." ; rdfs:label "Abnormality of B cell physiology" ; rdfs:subClassOf obo:HP_0031409 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005374 obo:IAO_0000115 "An immunodeficiency characterized by defective cell-mediated immunity or humoral immunity." ; oboInOwl:hasAlternativeId "HP:0005375" ; oboInOwl:hasDbXref "UMLS:C1855204" ; oboInOwl:id "HP:0005374" ; a owl:Class ; rdfs:label "Cellular immunodeficiency" ; rdfs:subClassOf obo:HP_0002721 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006955 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:CL_0000000 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005375 obo:IAO_0100001 "HP:0005374" ; oboInOwl:id "HP:0005375" ; a owl:Class ; rdfs:label "obsolete Partial cellular immunodeficiency" ; owl:deprecated true . obo:HP_0005376 obo:IAO_0000115 "Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent episodes of infection by Haemophilus influenzae." ; oboInOwl:hasDbXref "UMLS:C4025204" ; oboInOwl:hasExactSynonym "Recurrent H. influenzae infections" ; oboInOwl:id "HP:0005376" ; a owl:Class ; rdfs:label "Recurrent Haemophilus influenzae infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0005379 oboInOwl:consider "HP:0005403" ; oboInOwl:id "HP:0005379" ; a owl:Class ; rdfs:label "obsolete Severe T lymphocytopenia" ; owl:deprecated true . obo:HP_0005381 obo:IAO_0000115 "Recurrent infections by Neisseria meningitidis (one of the most common causes of bacterial meningitis), which is also known as meningococcus." ; oboInOwl:hasAlternativeId "HP:0005414" ; oboInOwl:hasDbXref "UMLS:C1970263" ; oboInOwl:hasExactSynonym "Increased susceptibility to neisseria meningitidis infections" ; oboInOwl:id "HP:0005381" ; a owl:Class ; rdfs:label "Recurrent meningococcal disease" ; rdfs:subClassOf obo:HP_0005430 . obo:HP_0005384 obo:IAO_0000115 "A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of" ; oboInOwl:hasDbXref "UMLS:C1846551" ; oboInOwl:id "HP:0005384" ; a owl:Class ; rdfs:label "Defective B cell activation" ; rdfs:subClassOf obo:HP_0005372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005386 obo:IAO_0000115 "Increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection." ; oboInOwl:hasDbXref "UMLS:C4025202" ; oboInOwl:id "HP:0005386" ; a owl:Class ; rdfs:label "Recurrent protozoan infections" ; rdfs:subClassOf obo:HP_0002719 . obo:HP_0005387 obo:IAO_0000115 "A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications." ; oboInOwl:hasDbXref "UMLS:C0494261" ; oboInOwl:id "HP:0005387" ; a owl:Class ; rdfs:label "Combined immunodeficiency" ; rdfs:subClassOf obo:HP_0002721 . obo:HP_0005389 obo:IAO_0000115 "An abnormal reduction in the components of the alternative complement pathway, such as the C3 protein or its cleavage products." ; oboInOwl:hasDbXref "UMLS:C1969220" ; oboInOwl:id "HP:0005389" ; a owl:Class ; rdfs:label "Depletion of components of the alternative complement pathway" ; rdfs:subClassOf obo:HP_0005482 . obo:HP_0005390 obo:IAO_0000115 "Increased susceptibility to opportunistic infections, as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system." ; oboInOwl:hasAlternativeId "HP:0005426" ; oboInOwl:hasDbXref "UMLS:C1832324" ; oboInOwl:hasExactSynonym "Frequent opportunistic infections" ; oboInOwl:id "HP:0005390" ; a owl:Class ; rdfs:label "Recurrent opportunistic infections" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0031690 . obo:HP_0005396 obo:IAO_0000115 "Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e." ; oboInOwl:hasDbXref "UMLS:C1852539" ; oboInOwl:id "HP:0005396" ; a owl:Class ; rdfs:label "Susceptibility to coronavirus 229e" ; rdfs:subClassOf obo:HP_0004429 . obo:HP_0005397 oboInOwl:consider "HP:0011840" ; oboInOwl:id "HP:0005397" ; a owl:Class ; rdfs:label "obsolete Exaggerated cellular immune processes" ; owl:deprecated true . obo:HP_0005400 obo:IAO_0000115 "An abnormal reduction of the cell motility of neutrophils." ; oboInOwl:hasDbXref "UMLS:C4025201" ; oboInOwl:id "HP:0005400" ; a owl:Class ; rdfs:label "Reduction of neutrophil motility" ; rdfs:subClassOf obo:HP_0011990 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002297 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005401 obo:IAO_0000115 "An increased susceptibility to candida infections, as manifested by a history of recurrent episodes of candida infections." ; oboInOwl:hasDbXref "UMLS:C1860128" ; oboInOwl:hasExactSynonym "Frequent candida infections" ; oboInOwl:id "HP:0005401" ; a owl:Class ; rdfs:label "Recurrent candida infections" ; rdfs:subClassOf obo:HP_0002841 . obo:HP_0005402 obo:IAO_0100001 "HP:0011840" ; oboInOwl:id "HP:0005402" ; a owl:Class ; rdfs:label "obsolete Primary T-lymphocyte immune abnormalities" ; owl:deprecated true . obo:HP_0005403 obo:IAO_0000115 "An abnormally low count of T cells." ; oboInOwl:hasAlternativeId "HP:0005412", "HP:0045071" ; oboInOwl:hasDbXref "MSH:C536783", "UMLS:C2931322" ; oboInOwl:hasExactSynonym "Decrease in T cell count", "Decrease in T cell number", "Decreased numbers of circulating T cells", "Low T cell count", "Reduced number of T cells" ; oboInOwl:id "HP:0005403" ; a owl:Class ; rdfs:label "T lymphocytopenia" ; rdfs:subClassOf obo:HP_0001888, obo:HP_0011839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005404 obo:IAO_0000115 "An abnormal increase from the normal count of B cells." ; oboInOwl:hasDbXref "UMLS:C1858972" ; oboInOwl:hasExactSynonym "Increase in B cell count", "Increase in B cell number", "Increased number of B cells" ; oboInOwl:id "HP:0005404" ; a owl:Class ; rdfs:label "Increased B cell count" ; rdfs:subClassOf obo:HP_0010975, obo:HP_0100827 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005406 obo:IAO_0000115 "Increased susceptibility to bacterial infections of the skin, as manifested by recurrent episodes of infectious dermatitis." ; oboInOwl:hasAlternativeId "HP:0000983" ; oboInOwl:hasDbXref "UMLS:C1835686" ; oboInOwl:hasExactSynonym "Recurrent bacterial skin infections", "Recurrent cutaneous pyogenic infections", "Recurrent episodes of impetigo", "Recurrent episodes of infectious dermatitis", "Recurrent pyogenic skin infections" ; oboInOwl:id "HP:0005406" ; a owl:Class ; rdfs:comment "Infectious dermatitis may manifest as impetigo, multiple purulent blisters, erythema, lymphadenopathy near the site of infection." ; rdfs:label "Recurrent bacterial skin infections" ; rdfs:subClassOf obo:HP_0001581, obo:HP_0002718 . obo:HP_0005407 obo:IAO_0000115 "A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count." ; oboInOwl:hasAlternativeId "HP:0005480" ; oboInOwl:hasDbXref "UMLS:C1839304" ; oboInOwl:hasExactSynonym "Abnormality of CD4+ T cells", "CD4 T cell lymphopenia", "CD4+ T-cell lymphopenia" ; oboInOwl:id "HP:0005407" ; a owl:Class ; rdfs:label "Decreased proportion of CD4-positive helper T cells" ; rdfs:subClassOf obo:HP_0005403, obo:HP_0032218, obo:HP_0500267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005409 obo:IAO_0100001 "HP:0005435" ; oboInOwl:id "HP:0005409" ; a owl:Class ; rdfs:label "obsolete Markedly reduced T cell function" ; owl:deprecated true . obo:HP_0005411 obo:IAO_0000115 "Persistent overgrowth of Candida albicans in the gastrointestinal tract." ; oboInOwl:hasDbXref "UMLS:C4020823", "UMLS:C4025199" ; oboInOwl:hasRelatedSynonym "Candida overgrowth syndrome" ; oboInOwl:id "HP:0005411" ; a owl:Class ; rdfs:label "Chronic intestinal candidiasis" ; rdfs:subClassOf obo:HP_0002728 . obo:HP_0005413 obo:IAO_0000115 "An abnormally increased level of circulating alpha-globulin. Alpha globulins are a group of serum proteins defined by their mobility on serum electrophoresis. The alpha1-protein fraction is comprised of alpha1-antitrypsin, thyroid-binding globulin, and transcortin. Ceruloplasmin, alpha2-macroglobulin, and haptoglobin contribute to the alpha2-protein band. The alpha2 component is increased as an acute-phase reactant." ; oboInOwl:hasDbXref "SNOMEDCT_US:124022007", "UMLS:C1167806" ; oboInOwl:id "HP:0005413" ; a owl:Class ; rdfs:label "Increased alpha-globulin" ; rdfs:subClassOf obo:HP_0032311 . obo:HP_0005415 obo:IAO_0000115 "A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells." ; oboInOwl:hasAlternativeId "HP:0005481" ; oboInOwl:hasDbXref "UMLS:C1839305" ; oboInOwl:hasExactSynonym "CD8+ T-cell lymphopenia", "Decreased proportion of CD8+ T cells", "Decreased proportion of CD8-positive, alpha-beta T cells" ; oboInOwl:id "HP:0005415" ; a owl:Class ; rdfs:label "Decreased proportion of CD8-positive T cells" ; rdfs:subClassOf obo:HP_0005403, obo:HP_0031393 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005416 obo:IAO_0000115 "Concentration of the complement component factor B in the blood circulation below the lower limit of normal." ; oboInOwl:hasDbXref "UMLS:C4021636" ; oboInOwl:hasExactSynonym "Decreased serum complement factor B", "Decreased serum factor b" ; oboInOwl:id "HP:0005416" ; a owl:Class ; rdfs:label "Decreased circulating complement factor B concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0005419 obo:IAO_0000115 "Decreased or impaired activation of T cells in response to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; oboInOwl:hasAlternativeId "HP:0005370", "HP:0005436" ; oboInOwl:hasDbXref "UMLS:C1846550" ; oboInOwl:hasExactSynonym "Decreased T lymphocyte activation", "Decreased T-cell activation", "Decreased T-lymphocyte activation", "Defective T cell activation", "Profound depletion of T4+ lymphocytes" ; oboInOwl:id "HP:0005419" ; a owl:Class ; rdfs:label "Decreased T cell activation" ; rdfs:subClassOf obo:HP_0410035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005420 obo:IAO_0000115 "Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents." ; oboInOwl:hasAlternativeId "HP:0005395" ; oboInOwl:hasDbXref "UMLS:C4025198" ; oboInOwl:id "HP:0005420" ; a owl:Class ; rdfs:comment "Gram-negative bacteria have a unique outer membrane, a thinner layer of peptidoglycan compared to gram-positive bacteria, and a periplasmic space between the cell wall and the membrane." ; rdfs:label "Recurrent gram-negative bacterial infections" ; rdfs:subClassOf obo:HP_0002718 . obo:HP_0005421 obo:IAO_0000115 "Concentration of the complement component C3 in the blood circulation below the lower limit of normal." ; oboInOwl:hasAlternativeId "HP:0005408" ; oboInOwl:hasDbXref "UMLS:C1837512" ; oboInOwl:hasExactSynonym "Decreased serum C3", "Decreased serum complement C3", "Decreased serum complement C3 level" ; oboInOwl:id "HP:0005421" ; a owl:Class ; rdfs:label "Decreased circulating complement C3 concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0005422 obo:IAO_0000115 "Lack of detectible CD8-positive T cells" ; oboInOwl:hasDbXref "UMLS:C4025197" ; oboInOwl:hasExactSynonym "Absence of CD8+ T cells" ; oboInOwl:id "HP:0005422" ; a owl:Class ; rdfs:label "Absence of CD8-positive T cells" ; rdfs:subClassOf obo:HP_0005415 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005423 obo:IAO_0000115 "An abnormality of the functioning of any aspect of the alternative complement pathway." ; oboInOwl:hasDbXref "UMLS:C1839458" ; oboInOwl:id "HP:0005423" ; a owl:Class ; rdfs:label "Dysfunctional alternative complement pathway" ; rdfs:subClassOf obo:HP_0005482 . obo:HP_0005424 obo:IAO_0000115 "Absence of specific immunoglobulins directed against a specific antigen or microorganism." ; oboInOwl:hasDbXref "UMLS:C1863246" ; oboInOwl:id "HP:0005424" ; a owl:Class ; rdfs:label "Absent specific antibody response" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0005425 obo:IAO_0000115 "An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections." ; oboInOwl:hasDbXref "UMLS:C1846546" ; oboInOwl:hasExactSynonym "Chronic sinopulmonary infection", "Recurrent sinus and lung infections" ; oboInOwl:id "HP:0005425" ; a owl:Class ; rdfs:label "Recurrent sinopulmonary infections" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0005428 oboInOwl:hasDbXref "MSH:C563458", "UMLS:C1833487" ; oboInOwl:id "HP:0005428" ; a owl:Class ; rdfs:label "Severe recurrent varicella" ; rdfs:subClassOf obo:HP_0004429 . obo:HP_0005429 obo:IAO_0000115 "Increased susceptibility to systemic pyogenic infections, as manifested by recurrent episodes of systemic pyogenic infections." ; oboInOwl:hasDbXref "UMLS:C4025196" ; oboInOwl:id "HP:0005429" ; a owl:Class ; rdfs:label "Recurrent systemic pyogenic infections" ; rdfs:subClassOf obo:HP_0002718 . obo:HP_0005430 obo:IAO_0000115 "Recurrent infections by bacteria of the genus Neisseria, including N. meningitidis (one of the most common causes of bacterial meningitis)." ; oboInOwl:hasAlternativeId "HP:0005377", "HP:0005378" ; oboInOwl:hasDbXref "UMLS:C3151083" ; oboInOwl:hasExactSynonym "Episodes of neisserial infection", "Recurrent neisseria infections" ; oboInOwl:id "HP:0005430" ; a owl:Class ; rdfs:label "Recurrent Neisserial infections" ; rdfs:subClassOf obo:HP_0005420 . obo:HP_0005432 obo:IAO_0000115 "At birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient newborn hypogammaglobulinemia." ; oboInOwl:hasDbXref "SNOMEDCT_US:88714009", "UMLS:C0272238", "UMLS:C4020822" ; oboInOwl:hasRelatedSynonym "Newborn gammaglobulin deficiency" ; oboInOwl:id "HP:0005432" ; a owl:Class ; rdfs:label "Transient hypogammaglobulinemia of infancy" ; rdfs:subClassOf obo:HP_0004313 . obo:HP_0005435 obo:IAO_0000115 "Abnormally reduced ability of T cells to perform their functions in cell-mediated immunity." ; oboInOwl:hasAlternativeId "HP:0002844", "HP:0005373", "HP:0005383", "HP:0005409" ; oboInOwl:hasDbXref "UMLS:C1860127" ; oboInOwl:hasExactSynonym "Impaired T cell function", "T-cell dysfunction" ; oboInOwl:id "HP:0005435" ; a owl:Class ; rdfs:label "Impaired T cell function" ; rdfs:subClassOf obo:HP_0011840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005437 obo:IAO_0000115 "Recurrent infections at an early age with improvement in later childhood." ; oboInOwl:hasDbXref "UMLS:C1844909" ; oboInOwl:id "HP:0005437" ; a owl:Class ; rdfs:label "Recurrent infections in infancy and early childhood" ; rdfs:subClassOf obo:HP_0002719 . obo:HP_0005439 obo:IAO_0000115 "Hypoplasia of the maxillozygomatic complex." ; oboInOwl:hasDbXref "UMLS:C1848908", "UMLS:C4280488" ; oboInOwl:hasExactSynonym "Decreased size of zygomaticomaxillary bone complex", "Deficiency of zygomaticomaxillary bone complex", "Hypoplasia of malar bone complex", "Hypoplasia of zygomaticomaxillary complex", "Underdevelopment of zygomaticomaxillary bone complex" ; oboInOwl:hasRelatedSynonym "Decreased projection of zygomaticomaxillary bone complex" ; oboInOwl:id "HP:0005439" ; a owl:Class ; rdfs:label "Maxillozygomatic hypoplasia" ; rdfs:subClassOf obo:HP_0000327, obo:HP_0010669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000327 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010669 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005441 obo:IAO_0000115 "An increased density in the cranial sutures following obliteration." ; oboInOwl:hasDbXref "UMLS:C4025195" ; oboInOwl:id "HP:0005441" ; a owl:Class ; rdfs:label "Sclerotic cranial sutures" ; rdfs:subClassOf obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003685 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0005442 obo:IAO_0000115 "The presence of a coronal suture (the cranial suture that separates the frontal and parietal bones) that is not ossified but rather wide open at an age when it is normally closed." ; oboInOwl:hasDbXref "UMLS:C1856778" ; oboInOwl:id "HP:0005442" ; a owl:Class ; rdfs:label "Widely patent coronal suture" ; rdfs:subClassOf obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000610 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005445 obo:IAO_0000115 "Abnormal increased size of the posterior cranial fossa." ; oboInOwl:hasDbXref "UMLS:C1855889" ; oboInOwl:hasExactSynonym "Widened posterior fossa" ; oboInOwl:id "HP:0005445" ; a owl:Class ; rdfs:label "Enlarged posterior fossa" ; rdfs:subClassOf obo:HP_0000932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008788 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005446 obo:IAO_0000115 "Abnormally flat (obtuse) angle of the mandible. The angle of the mandibular, located at the junction between the body and the ramus of the mandible, is normally close to being a right angle. This terms describes an abnormal increase of this angle such that the mandible appears flatter than normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:709997007", "UMLS:C4038738" ; oboInOwl:hasExactSynonym "High mandibular plane angle", "Steep mandibular plane angle" ; oboInOwl:id "HP:0005446" ; a owl:Class ; rdfs:comment "See PMID:17213440 Figure 1G for an example of an obtuse mandibular angle." ; rdfs:label "Obtuse angle of mandible" ; rdfs:subClassOf obo:HP_0000277 . obo:HP_0005449 oboInOwl:hasDbXref "MSH:C566689", "UMLS:C1866959" ; oboInOwl:id "HP:0005449" ; a owl:Class ; rdfs:label "Bridged sella turcica" ; rdfs:subClassOf obo:HP_0002681 . obo:HP_0005450 obo:IAO_0000115 "An increase in bone density affecting the calvaria (roof of the skull)." ; oboInOwl:hasDbXref "UMLS:C1855657" ; oboInOwl:id "HP:0005450" ; a owl:Class ; rdfs:label "Calvarial osteosclerosis" ; rdfs:subClassOf obo:HP_0005464 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004339 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005451 oboInOwl:hasDbXref "UMLS:C1835442" ; oboInOwl:id "HP:0005451" ; a owl:Class ; rdfs:label "Decreased cranial base ossification" ; rdfs:subClassOf obo:HP_0004331 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002517 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005453 obo:IAO_0000115 "Aplasia or hypoplasia of the paranasal sinuses." ; oboInOwl:hasDbXref "UMLS:C1856639" ; oboInOwl:id "HP:0005453" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent/hypoplastic paranasal sinuses" ; rdfs:subClassOf obo:HP_0009120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001825 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005456 obo:IAO_0000115 "Lack (aplasia) of the ethmoidal sinus." ; oboInOwl:hasDbXref "UMLS:C4025194" ; oboInOwl:hasExactSynonym "Agenesis of ethmoid sinuses", "Failure of development of ethmoid sinuses", "Missing ethmoid sinuses" ; oboInOwl:id "HP:0005456" ; a owl:Class ; rdfs:label "Absent ethmoidal sinuses" ; rdfs:subClassOf obo:HP_0002689, obo:HP_3000040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005458 obo:IAO_0000115 "Normally, the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior fontanelle closes by about the middle of the second year. This term refers to the situation in which the fontanelles close at an inappropriately early time point." ; oboInOwl:hasBroadSynonym "Early closure of the cranial sutures", "Premature closure of the cranial sutures" ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:1667003", "SNOMEDCT_US:57219006", "UMLS:C0010278", "UMLS:C0277827", "UMLS:C4072853" ; oboInOwl:hasExactSynonym "Early closure of the fontanelles", "Obliterated fontanelles" ; oboInOwl:hasNarrowSynonym "Early closure of the bregma sutures", "Premature closure of the bregma sutures" ; oboInOwl:id "HP:0005458" ; a owl:Class ; rdfs:label "Premature closure of fontanelles" ; rdfs:subClassOf obo:HP_0011328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005461 oboInOwl:hasDbXref "UMLS:C1867114" ; oboInOwl:id "HP:0005461" ; a owl:Class ; rdfs:label "Craniofacial disproportion" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0005462 obo:IAO_0000115 "The presence of calcium deposition in the falx cerebri." ; oboInOwl:hasDbXref "UMLS:C1397139" ; oboInOwl:id "HP:0005462" ; a owl:Class ; rdfs:label "Calcification of falx cerebri" ; rdfs:subClassOf obo:HP_0002514, obo:HP_0010653 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005463 oboInOwl:hasDbXref "UMLS:C1863311" ; oboInOwl:id "HP:0005463" ; a owl:Class ; rdfs:label "Elongated sella turcica" ; rdfs:subClassOf obo:HP_0002681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001154 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005464 obo:IAO_0000115 "Abnormally increased density of craniofacial bone tissue." ; oboInOwl:hasDbXref "UMLS:C1845805", "UMLS:C4025193" ; oboInOwl:hasRelatedSynonym "Cranial sclerosis" ; oboInOwl:id "HP:0005464" ; a owl:Class ; rdfs:label "Craniofacial osteosclerosis" ; rdfs:subClassOf obo:HP_0011001, obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0011156 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005465 obo:IAO_0000115 "Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton." ; oboInOwl:hasAlternativeId "HP:0008508" ; oboInOwl:hasBroadSynonym "Enlargement of facial bones", "Enlargement of facial skeleton", "Hypertrophy of facial bones", "Hypertrophy of facial skeleton" ; oboInOwl:hasDbXref "UMLS:C1857501", "UMLS:C4280485", "UMLS:C4280486", "UMLS:C4280487" ; oboInOwl:hasExactSynonym "Enlargment of the facial bones", "Excessive growth of facial bones", "Excessive growth of facial skeleton", "Hyperostosis of facial bones", "Hyperostosis of facial skeleton", "Hypertrophy of the facial bones", "Increase in size of the facial bones", "Overgrowth of facial bones", "Overgrowth of facial skeleton", "Overgrowth of the facial bones" ; oboInOwl:hasRelatedSynonym "Increased ossification of facial bones", "Increased ossification of facial skeleton" ; oboInOwl:id "HP:0005465" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Facial hyperostosis" ; rdfs:subClassOf obo:HP_0004493 . obo:HP_0005466 obo:IAO_0000115 "Underdevelopment of the frontal bone." ; oboInOwl:hasAlternativeId "HP:0005493" ; oboInOwl:hasDbXref "UMLS:C1845147", "UMLS:C4280483", "UMLS:C4280484" ; oboInOwl:hasExactSynonym "Decreased size of bone of forehead", "Hypoplastic frontal bones", "Small bone of forehead", "Underdevelopment of bone of forehead" ; oboInOwl:hasRelatedSynonym "Hypotrophic frontal bone", "Hypotrophic frontal bones", "Thin bone of forehead" ; oboInOwl:id "HP:0005466" ; a owl:Class ; rdfs:label "Hypoplasia of the frontal bone" ; rdfs:subClassOf obo:HP_0002692, obo:HP_0011218 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005469 obo:IAO_0000115 "Reduced convexity of the occiput (posterior part of skull)." ; oboInOwl:hasAlternativeId "HP:0000247", "HP:0000249" ; oboInOwl:hasBroadSynonym "Flat back of skull", "Flat back of the head", "Flat back of the skull", "Flat posterior head" ; oboInOwl:hasDbXref "UMLS:C1837402", "UMLS:C4280482" ; oboInOwl:hasExactSynonym "Flat posterior cranium", "Posterior flattening of the skull" ; oboInOwl:id "HP:0005469" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Reduced convexity of the occiput gives an appearance of flattening. There are no objective measures for convexity of the occiput, and evaluation depends heavily on the experience of the observer. This finding may or may not be accompanied by Brachycephaly (which should be coded separately), and may be observed more frequently when an infant is placed to sleep on his/her back. Occipital plagiocephaly can result from fusion or sclerosis of the lambdoid suture. If unilateral, this is accompanied by unilateral occipital flattening and bulging of the ispilateral frontal bone." ; rdfs:label "Flat occiput" ; rdfs:subClassOf obo:HP_0011217 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005472 oboInOwl:hasDbXref "UMLS:C4025192" ; oboInOwl:id "HP:0005472" ; a owl:Class ; rdfs:label "Orbital craniosynostosis" ; rdfs:subClassOf obo:HP_0001363, obo:HP_3000030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005473 obo:IAO_0000115 "Bony fusion of malleus, incus, and stapes." ; oboInOwl:hasDbXref "UMLS:C1862068" ; oboInOwl:id "HP:0005473" ; a owl:Class ; rdfs:label "Fusion of middle ear ossicles" ; rdfs:subClassOf obo:HP_0004452, obo:HP_0100240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001686 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001686 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005474 obo:IAO_0000115 "Abnormal reduction in ossification of the calvaria (roof of the skull consisting of the frontal bone, parietal bones, temporal bones, and occipital bone)." ; oboInOwl:hasAlternativeId "HP:0002701", "HP:0002702", "HP:0005454", "HP:0005471" ; oboInOwl:hasDbXref "UMLS:C1833762" ; oboInOwl:hasExactSynonym "Poorly ossified calvaria", "Poorly ossified calvarium", "Soft calvaria", "Soft skullcap", "Undermineralized calvarium" ; oboInOwl:hasRelatedSynonym "Skull soft on palpation" ; oboInOwl:id "HP:0005474" ; a owl:Class ; rdfs:comment "A hypomineralised skull castes little or no acoustic shadow on prenatal ultrasound. This makes visualisation of the intracranial anatomy clearer than normal. In conditions associated with profound hypomineralisation, the skull shape can be distorted by pressure from the ultrasound transducer later in pregnancy." ; rdfs:label "Decreased calvarial ossification" ; rdfs:subClassOf obo:HP_0002683, obo:HP_0004331 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004339 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005476 obo:IAO_0000115 "The presence of a sagittal suture (the cranial suture that separates the left and right parietal bones) that is not ossified but rather wide open at an age when it is normally closed." ; oboInOwl:hasDbXref "UMLS:C1856779" ; oboInOwl:id "HP:0005476" ; a owl:Class ; rdfs:label "Widely patent sagittal suture" ; rdfs:subClassOf obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000610 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002492 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005477 obo:IAO_0000115 "Progressively increasing bone density of the skull base without significant changes in bony contour." ; oboInOwl:hasDbXref "UMLS:C1835470" ; oboInOwl:id "HP:0005477" ; a owl:Class ; rdfs:label "Progressive sclerosis of skull base" ; rdfs:subClassOf obo:HP_0002694 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001818 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002517 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005478 oboInOwl:hasDbXref "UMLS:C1969404", "UMLS:C4280265", "UMLS:C4280479", "UMLS:C4280480", "UMLS:C4280481" ; oboInOwl:hasExactSynonym "Large frontal sinus" ; oboInOwl:hasRelatedSynonym "Hyperplasia of frontal sinus", "Hypertrophy of frontal sinus", "Increased size of frontal sinus", "Increased volume of frontal sinus" ; oboInOwl:id "HP:0005478" ; a owl:Class ; rdfs:label "Prominent frontal sinuses" ; rdfs:subClassOf obo:HP_0002687 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001760 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005479 obo:IAO_0000115 "An abnormally decreased level of immunoglobulin E (IgE) in blood." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T08:03:00Z" ; oboInOwl:hasAlternativeId "HP:0002854" ; oboInOwl:hasDbXref "UMLS:C0860904" ; oboInOwl:hasExactSynonym "Decreased IgE", "IgE deficiency" ; oboInOwl:id "HP:0005479" ; a owl:Class ; rdfs:label "Decreased circulating IgE" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0410241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071743 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005482 obo:IAO_0000115 "A deviation in any aspect of the alternative complement pathway." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T08:12:00Z" ; oboInOwl:hasDbXref "UMLS:C4025191" ; oboInOwl:id "HP:0005482" ; a owl:Class ; rdfs:comment "The alternative complement pathway is one of three complement pathways, which is an innate component of the immune system's natural defense against infections. The alternative complement pathway has three unique components, factor B, factor D, and properdin." ; rdfs:label "Abnormality of the alternative complement pathway" ; rdfs:subClassOf obo:HP_0005339 . obo:HP_0005483 obo:IAO_0000115 "An abnormality of the epiglottis." ; dcterms:creator ; oboInOwl:creation_date "2008-03-26T08:25:00Z" ; oboInOwl:hasDbXref "UMLS:C4025190" ; oboInOwl:hasExactSynonym "Abnormality of the epiglottis" ; oboInOwl:id "HP:0005483" ; a owl:Class ; rdfs:label "Abnormal epiglottis morphology" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005484 obo:IAO_0000115 "Head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth." ; oboInOwl:hasAlternativeId "HP:0000241", "HP:0000259", "HP:0005499" ; oboInOwl:hasBroadSynonym "Development of small head that was not present at birth" ; oboInOwl:hasDbXref "UMLS:C1847514" ; oboInOwl:hasExactSynonym "Acquired microcephaly", "Deceleration of head growth", "Microcephaly, acquired", "Microcephaly, postnatal", "Postnatal deceleration of head circumference", "Postnatal microcephaly" ; oboInOwl:id "HP:0005484" ; a owl:Class ; rdfs:label "Secondary microcephaly" ; rdfs:subClassOf obo:HP_0000252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035265 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005486 obo:IAO_0000115 "A fontanelle that is small for age." ; oboInOwl:hasBroadSynonym "Little cranial sutures", "Small cranial sutures" ; oboInOwl:hasDbXref "SNOMEDCT_US:276710001", "UMLS:C0456133", "UMLS:C4072854", "UMLS:C4072855" ; oboInOwl:hasExactSynonym "Little fontanelle", "Microfontanelle", "Small soft spot" ; oboInOwl:hasNarrowSynonym "Small bregma sutures" ; oboInOwl:id "HP:0005486" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Small fontanelle" ; rdfs:subClassOf obo:HP_0011328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005487 obo:IAO_0000115 "Vertical bony ridge positioned in the midline of the forehead." ; oboInOwl:hasAlternativeId "HP:0005488", "HP:0005751" ; oboInOwl:hasDbXref "UMLS:C1857949" ; oboInOwl:hasExactSynonym "Prominent frontal ridge", "Prominent metopic suture", "Ridging of metopic suture" ; oboInOwl:hasNarrowSynonym "Prominent frontal suture", "Ridging of frontal suture" ; oboInOwl:id "HP:0005487" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The ridge may extend from the hairline to the glabella or may be partial. The frontal suture of the skull is a dense connective tissue structure that divides the two halves of the frontal bone of the skull in infants and children and usually undergoes closure by the age of six years. A persistent frontal suture is known as a metopic suture or sutura frontalis persistens. This can lead to a ridged appearance of the forehead." ; rdfs:label "Prominent metopic ridge" ; rdfs:subClassOf obo:HP_0005556 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005490 obo:IAO_0000115 "The postnatal development of an abnormally large skull (macrocephaly)." ; oboInOwl:hasDbXref "UMLS:C1854417" ; oboInOwl:hasExactSynonym "Macrocephaly, postnatal" ; oboInOwl:id "HP:0005490" ; a owl:Class ; rdfs:label "Postnatal macrocephaly" ; rdfs:subClassOf obo:HP_0000256 . obo:HP_0005494 oboInOwl:hasDbXref "UMLS:C1839126" ; oboInOwl:id "HP:0005494" ; a owl:Class ; rdfs:label "Premature posterior fontanelle closure" ; rdfs:subClassOf obo:HP_0005458 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005495 obo:IAO_0000115 "The frontal suture divides the two halves of the frontal bone in infants and usually fuses by the age of six years. The suture runs from the bregma (the point on the skull at which the coronal suture is intersected perpendicularly by the sagittal suture) to the nasion or nasal root. This term applies if the suture is widely patent from bregma to nasal root." ; oboInOwl:hasDbXref "UMLS:C4025189" ; oboInOwl:id "HP:0005495" ; a owl:Class ; rdfs:comment "This feature is a characteristic of Schinzel-Giedion midface retraction syndrome." ; rdfs:label "Metopic suture patent to nasal root" ; rdfs:subClassOf obo:HP_0005556 . obo:HP_0005498 oboInOwl:hasDbXref "UMLS:C1855690" ; oboInOwl:id "HP:0005498" ; a owl:Class ; rdfs:label "Midline skin dimples over anterior/posterior fontanelles" ; rdfs:subClassOf obo:HP_0000236 . obo:HP_0005502 oboInOwl:hasDbXref "UMLS:C1849478" ; oboInOwl:hasExactSynonym "Increased erythrocyte osmotic fragility", "Increased red cell fragility" ; oboInOwl:id "HP:0005502" ; a owl:Class ; rdfs:label "Increased red cell osmotic fragility" ; rdfs:subClassOf obo:HP_0020054 . obo:HP_0005505 oboInOwl:hasDbXref "MSH:D000753", "SNOMEDCT_US:128845005", "UMLS:C0002893" ; oboInOwl:hasExactSynonym "Refractory anaemia" ; oboInOwl:id "HP:0005505" ; a owl:Class ; rdfs:label "Refractory anemia" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0005506 obo:IAO_0000115 "A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate." ; oboInOwl:hasAlternativeId "HP:0005544" ; oboInOwl:hasDbXref "DOID:8552", "MSH:D015464", "SNOMEDCT_US:63364005", "SNOMEDCT_US:92818009", "UMLS:C0023473" ; oboInOwl:hasExactSynonym "Chronic myelocytic leukaemia", "Chronic myelocytic leukemia", "Chronic myelogenous leukaemia", "Chronic myeloid leukaemia", "Chronic myeloid leukemia" ; oboInOwl:id "HP:0005506" ; a owl:Class ; rdfs:label "Chronic myelogenous leukemia" ; rdfs:subClassOf obo:HP_0005558 . obo:HP_0005507 obo:IAO_0000115 "Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues." ; oboInOwl:hasDbXref "UMLS:C3539063" ; oboInOwl:hasExactSynonym "Haemoglobin Barts", "Hb Barts" ; oboInOwl:id "HP:0005507" ; a owl:Class ; rdfs:comment "Hb Bart is normally not present in adult blood. It makes up about 85-90 percent of hemoglobin in Hb Bart hydrops fetalis syndrome, and about 2-5 percent in HbH disease." ; rdfs:label "Hemoglobin Barts" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0005508 obo:IAO_0000115 "Presence of a monoclonal immunoglobulin M protein in the serum." ; oboInOwl:hasDbXref "MSH:D008258", "SNOMEDCT_US:190817009", "SNOMEDCT_US:190818004", "SNOMEDCT_US:35562000", "UMLS:C0024419" ; oboInOwl:hasRelatedSynonym "Waldenstrom macroglobulinemia" ; oboInOwl:id "HP:0005508" ; a owl:Class ; rdfs:comment "This is a characteristic feature of Waldenstrom macroglobulinemia (WM), which is defined as a B-cell lymphoplasmacytic lymphoma, characterized by monoclonal immunoglobulin M protein in the serum and infiltration of bone marrow with lymphoplasmacytic cells." ; rdfs:label "Monoclonal immunoglobulin M proteinemia" ; rdfs:subClassOf obo:HP_0003496, obo:HP_0005523, obo:HP_0031047 . obo:HP_0005510 obo:IAO_0000115 "A transient reduction in the number of erythroblasts in the circulation." ; oboInOwl:hasDbXref "UMLS:C4082199" ; oboInOwl:hasExactSynonym "Transient decrease in blood erythrocyte number" ; oboInOwl:id "HP:0005510" ; a owl:Class ; rdfs:comment "An erythroblast, the immediate precursor of a normal erythrocyte which, still retains a cell nucleus." ; rdfs:label "Transient erythroblastopenia" ; rdfs:subClassOf obo:HP_0001903 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005511 obo:IAO_0000115 "Anemia characterized by abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells." ; oboInOwl:hasDbXref "MSH:C563030", "UMLS:C0700299" ; oboInOwl:hasExactSynonym "Heinz body anaemia" ; oboInOwl:id "HP:0005511" ; a owl:Class ; rdfs:label "Heinz body anemia" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0005512 obo:IAO_0000115 "A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph." ; oboInOwl:hasDbXref "UMLS:C4025188" ; oboInOwl:id "HP:0005512" ; a owl:Class ; rdfs:label "Impaired neutrophil killing of staphylococci" ; rdfs:subClassOf obo:HP_0011993 . obo:HP_0005513 obo:IAO_0000115 "Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow." ; oboInOwl:hasDbXref "UMLS:C4025187" ; oboInOwl:id "HP:0005513" ; a owl:Class ; rdfs:label "Increased megakaryocyte count" ; rdfs:subClassOf obo:HP_0012143 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005517 obo:IAO_0000115 "A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas." ; oboInOwl:hasDbXref "UMLS:C4025186" ; oboInOwl:id "HP:0005517" ; a owl:Class ; rdfs:comment "T-cell lymphoma/leukemia is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1)." ; rdfs:label "T-cell lymphoma/leukemia" ; rdfs:subClassOf obo:HP_0012190 . obo:HP_0005518 obo:IAO_0000115 "Larger than normal size of erythrocytes." ; oboInOwl:hasAlternativeId "HP:0005536" ; oboInOwl:hasDbXref "UMLS:C0855791" ; oboInOwl:hasExactSynonym "Erythrocyte macrocytosis", "Increased MCV" ; oboInOwl:id "HP:0005518" ; a owl:Class ; rdfs:comment "Macrocytosis refers to a mean cell volume (MCV) greater than 100 fL. If macrocytosis is an isolated abnormality, the amount of hemoglobin in the cell increases proportionately, so the mean cell hemoglobin concentration (MCHC) remains within normal limits." ; rdfs:label "Increased mean corpuscular volume" ; rdfs:subClassOf obo:HP_0025065 . obo:HP_0005520 obo:IAO_0000115 "A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced." ; oboInOwl:hasDbXref "UMLS:C1862184" ; oboInOwl:hasExactSynonym "Chronic consumption coagulopathy", "Compensated disseminated intravascular coagulation" ; oboInOwl:id "HP:0005520" ; a owl:Class ; rdfs:label "Chronic disseminated intravascular coagulation" ; rdfs:subClassOf obo:HP_0005521 . obo:HP_0005521 obo:IAO_0000115 "Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels." ; oboInOwl:hasDbXref "MSH:D004211", "SNOMEDCT_US:67406007", "UMLS:C0012739" ; oboInOwl:id "HP:0005521" ; a owl:Class ; rdfs:comment "DIC is a complex syndrome in which there is pathological generation of thrombin and diffuse intravascular clot formation. DIC may occur as acute decompensated or chronic compensated form. In acute decompensated DIC, there is a sudden massive exposure of tissue factor over a brief time period; Intravascular coagulation can also compromise the blood supply to organs and, in conjunction with hemodynamic and metabolic derangements, may contribute to the failure of multiple organs. At the same time, the use and subsequent depletion of platelets and coagulation proteins resulting from the ongoing coagulation may induce severe bleeding. Chronic DIC, also known as compensated DIC, results from a persistent weak or intermittent activating stimulus. Under such conditions, destruction and production of coagulation factors and platelets are balanced." ; rdfs:label "Disseminated intravascular coagulation" ; rdfs:subClassOf obo:HP_0001977 . obo:HP_0005522 obo:IAO_0000115 "A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment." ; oboInOwl:hasDbXref "SNOMEDCT_US:191260004", "SNOMEDCT_US:25443007", "UMLS:C0272027" ; oboInOwl:hasExactSynonym "Pyridoxine-responsive sideroblastic anaemia" ; oboInOwl:id "HP:0005522" ; a owl:Class ; rdfs:label "Pyridoxine-responsive sideroblastic anemia" ; rdfs:subClassOf obo:HP_0001924 . obo:HP_0005523 oboInOwl:hasDbXref "MSH:D008232", "SNOMEDCT_US:277466009", "SNOMEDCT_US:414629003", "SNOMEDCT_US:77121009", "SNOMEDCT_US:84631004", "UMLS:C0024314" ; oboInOwl:hasRelatedSynonym "Lymphoproliferative disorders" ; oboInOwl:id "HP:0005523" ; a owl:Class ; rdfs:label "Lymphoproliferative disorder" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0005524 oboInOwl:hasDbXref "UMLS:C4025185" ; oboInOwl:id "HP:0005524" ; a owl:Class ; rdfs:label "Macrocytic hemolytic disease" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0005525 oboInOwl:hasDbXref "UMLS:C4025184" ; oboInOwl:id "HP:0005525" ; a owl:Class ; rdfs:label "Spontaneous hemolytic crises" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0005526 obo:IAO_0000115 "A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias." ; oboInOwl:hasDbXref "MSH:D007945", "SNOMEDCT_US:188725004", "SNOMEDCT_US:32280000", "UMLS:C0023448" ; oboInOwl:hasExactSynonym "Lymphoid leukaemia" ; oboInOwl:id "HP:0005526" ; a owl:Class ; rdfs:label "Lymphoid leukemia" ; rdfs:subClassOf obo:HP_0001909 . obo:HP_0005527 obo:IAO_0000115 "Reduction in the amount of kininogen, which functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade." ; oboInOwl:hasAlternativeId "HP:0004867", "HP:0005500", "HP:0005530", "HP:0005538" ; oboInOwl:hasDbXref "MSH:C537060", "SNOMEDCT_US:27312002", "UMLS:C0272340" ; oboInOwl:hasExactSynonym "Fitzgerald factor deficiency", "Kininogen deficiency", "Williams factor deficiency", "Williams-Fitzgerald-Flaujeac factor deficiency" ; oboInOwl:id "HP:0005527" ; a owl:Class ; rdfs:comment "Kininogen is cleaved into the following 6 chains: 1) Kininogen-1 heavy chain; 2) T-kinin; 3) Bradykinin; 4) Lysyl-bradykinin; 5) Kininogen-1 light chain; and 6) Low molecular weight growth-promoting factor." ; rdfs:label "Reduced kininogen activity" ; rdfs:subClassOf obo:HP_0005559, obo:HP_0010989 . obo:HP_0005528 obo:IAO_0000115 "A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat." ; oboInOwl:hasAlternativeId "HP:0005529", "HP:0100549" ; oboInOwl:hasDbXref "UMLS:C1855710" ; oboInOwl:hasExactSynonym "Bone marrow failure", "Bone marrow hypoplasia", "Hypoplastic bone marrow", "Myeloid hypoplasia" ; oboInOwl:id "HP:0005528" ; a owl:Class ; rdfs:label "Bone marrow hypocellularity" ; rdfs:subClassOf obo:HP_0012145 . obo:HP_0005531 obo:IAO_0000115 "A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias." ; oboInOwl:hasDbXref "MSH:D015456", "SNOMEDCT_US:128818009", "SNOMEDCT_US:278453007", "UMLS:C0023464" ; oboInOwl:hasExactSynonym "Acute biphenotypic leukaemia", "Biphenotypic acute leukaemia", "Myeloid/lymphoid leukaemia", "Myeloid/lymphoid leukemia" ; oboInOwl:id "HP:0005531" ; a owl:Class ; rdfs:label "Biphenotypic acute leukemia" ; rdfs:subClassOf obo:HP_0002488 . obo:HP_0005532 oboInOwl:hasDbXref "UMLS:C4025183" ; oboInOwl:hasExactSynonym "Macrocytic dyserythropoietic anaemia" ; oboInOwl:id "HP:0005532" ; a owl:Class ; rdfs:label "Macrocytic dyserythropoietic anemia" ; rdfs:subClassOf obo:HP_0001972 . obo:HP_0005534 obo:IAO_0000115 "A unique clonal neoplastic disorder that is linked to trisomy 21, is restricted to neonatal period, and spontaneously regresses. It often has characteristics of megakaryocytic lineage and is associated with GATA1 mutations in myeloblasts." ; oboInOwl:hasDbXref "MSH:C563551", "SNOMEDCT_US:450934005", "UMLS:C1834582" ; oboInOwl:hasExactSynonym "TMD", "Transient leukaemia of Down syndrome", "Transient leukemia of Down syndrome", "Transient myeloproliferative disorder" ; oboInOwl:id "HP:0005534" ; a owl:Class ; rdfs:label "Transient myeloproliferative syndrome" ; rdfs:subClassOf obo:HP_0005547 . obo:HP_0005535 obo:IAO_0000115 "A form of hemolytic anemia that can be triggered by exertion." ; oboInOwl:hasDbXref "UMLS:C4025182" ; oboInOwl:id "HP:0005535" ; a owl:Class ; rdfs:label "Exercise-induced hemolysis" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0005537 obo:IAO_0000115 "Average platelet volume below the lower limit of the normal reference interval." ; oboInOwl:hasAlternativeId "HP:0001938" ; oboInOwl:hasDbXref "UMLS:C1096368", "UMLS:C1833182" ; oboInOwl:hasExactSynonym "Small platelet size", "Small platelets", "Small platelets size" ; oboInOwl:id "HP:0005537" ; a owl:Class ; rdfs:comment "Mean platelet volume (MPV) is a measure of the average size of platelets, with a typical reference range of 7.5 to 11.5 femtoliters (fL)." ; rdfs:label "Decreased mean platelet volume" ; rdfs:subClassOf obo:HP_0011876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005539 obo:IAO_0000115 "A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent." ; oboInOwl:hasDbXref "UMLS:C4025181" ; oboInOwl:id "HP:0005539" ; a owl:Class ; rdfs:label "T cell chronic lymphocytic lymphoma/leukemia" ; rdfs:subClassOf obo:HP_0005526 . obo:HP_0005540 obo:IAO_0000115 "A form of poikilocytosis in which the abnormally shaped erythrocytes have notches that results in projections that look like horns." ; oboInOwl:hasDbXref "UMLS:C4021635" ; oboInOwl:hasExactSynonym "Distorted red blood cells resembling keratocytes", "RBC keratocytosis" ; oboInOwl:id "HP:0005540" ; a owl:Class ; rdfs:comment "Kerato- is derived from the Greek word for horn." ; rdfs:label "Red blood cell keratocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0005541 obo:IAO_0000115 "Congenital onset of a marked decrease in the number of granulocytes." ; oboInOwl:hasDbXref "MSH:C537592", "SNOMEDCT_US:89655007", "UMLS:C1853118" ; oboInOwl:id "HP:0005541" ; a owl:Class ; rdfs:label "Congenital agranulocytosis" ; rdfs:subClassOf obo:HP_0012234 . obo:HP_0005542 obo:IAO_0000115 "An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot." ; oboInOwl:hasAlternativeId "HP:0003229" ; oboInOwl:hasDbXref "UMLS:C0151563" ; oboInOwl:hasExactSynonym "Prolonged clotting time" ; oboInOwl:id "HP:0005542" ; a owl:Class ; rdfs:label "Prolonged whole-blood clotting time" ; rdfs:subClassOf obo:HP_0001928 . obo:HP_0005543 obo:IAO_0000115 "An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va." ; oboInOwl:hasDbXref "MSH:D020151", "SNOMEDCT_US:76407009", "UMLS:C0398625" ; oboInOwl:hasExactSynonym "Protein C deficiency" ; oboInOwl:id "HP:0005543" ; a owl:Class ; rdfs:comment "Protein C can function as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa. Therefore, a defect in protein C is associated with an increased risk of thrombosis." ; rdfs:label "Reduced protein C activity" ; rdfs:subClassOf obo:HP_0030780 . obo:HP_0005546 oboInOwl:hasDbXref "UMLS:C1858628" ; oboInOwl:id "HP:0005546" ; a owl:Class ; rdfs:label "Increased red cell osmotic resistance" ; rdfs:subClassOf obo:HP_0020054 . obo:HP_0005547 obo:IAO_0000115 "Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential." ; oboInOwl:hasDbXref "MSH:D009196", "SNOMEDCT_US:414794006", "SNOMEDCT_US:425333006", "UMLS:C0027022" ; oboInOwl:id "HP:0005547" ; a owl:Class ; rdfs:comment "There are four main myeloproliferative disroders, 1) chronic myelogenous leukemia (CML); 2) Polycythemia vera; 3) Essential thrombocytosis; and 4) Myelofibrosis." ; rdfs:label "Myeloproliferative disorder" ; rdfs:subClassOf obo:HP_0001909 . obo:HP_0005548 obo:IAO_0000115 "A reduced count of megakaryocytes." ; oboInOwl:hasDbXref "UMLS:C1858312" ; oboInOwl:hasExactSynonym "Megakaryocytes decreased im bone marrow" ; oboInOwl:id "HP:0005548" ; a owl:Class ; rdfs:comment "Megakaryocytes are giant cells in the bone marrow. Mature blood platelets are released from the cytoplasm of megakaryocytes." ; rdfs:label "Megakaryocytopenia" ; rdfs:subClassOf obo:HP_0012143 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000556 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005549 oboInOwl:consider "HP:0001875" ; oboInOwl:id "HP:0005549" ; a owl:Class ; rdfs:comment "This term was obsoleted - for annotation of congenital neutropenia, please use the class HP_0001875 Neutropenia and the Modifier Congenital Onset." ; rdfs:label "obsolete Congenital neutropenia" ; owl:deprecated true . obo:HP_0005550 obo:IAO_0000115 "A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias." ; oboInOwl:hasAlternativeId "HP:0006734", "HP:0006760" ; oboInOwl:hasDbXref "MSH:D015451", "SNOMEDCT_US:277473004", "SNOMEDCT_US:51092000", "SNOMEDCT_US:92814006", "UMLS:C0023434" ; oboInOwl:hasExactSynonym "Chronic lymphatic leukaemia", "Chronic lymphocytic leukaemia", "Chronic lymphocytic leukemia" ; oboInOwl:id "HP:0005550" ; a owl:Class ; rdfs:label "Chronic lymphatic leukemia" ; rdfs:subClassOf obo:HP_0005558 . obo:HP_0005556 obo:IAO_0000115 "The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a \"metopic suture\"." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4025180" ; oboInOwl:id "HP:0005556" ; a owl:Class ; rdfs:label "Abnormality of the metopic suture" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005557 obo:IAO_0000115 "An abnormality of the zygomatic arch, also known as the cheek bone." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:20:00Z" ; oboInOwl:hasDbXref "UMLS:C4025179" ; oboInOwl:hasExactSynonym "Abnormality of the malar arch", "Abnormality of the zygomatic arch" ; oboInOwl:hasNarrowSynonym "Anomaly of the malar arch", "Anomaly of the zygomatic arch", "Deformity of the malar arch", "Deformity of the zygomatic arch", "Malformation of the malar arch", "Malformation of the zygomatic arch" ; oboInOwl:id "HP:0005557" ; a owl:Class ; rdfs:comment "The zygomatic arch is formed by the zygomatic process of temporal bone and the temporal process of the zygomatic bone." ; rdfs:label "Abnormal zygomatic arch morphology" ; rdfs:subClassOf obo:HP_0010668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002500 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005558 obo:IAO_0000115 "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:32:00Z" ; oboInOwl:hasBroadSynonym "Chronic blood cancer" ; oboInOwl:hasDbXref "SNOMEDCT_US:128933000", "SNOMEDCT_US:92812005", "UMLS:C1279296", "UMLS:C4280478" ; oboInOwl:hasExactSynonym "Chronic leukaemia" ; oboInOwl:id "HP:0005558" ; a owl:Class ; rdfs:label "Chronic leukemia" ; rdfs:subClassOf obo:HP_0001909 . obo:HP_0005559 dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:34:00Z" ; oboInOwl:hasDbXref "UMLS:C4025178" ; oboInOwl:id "HP:0005559" ; a owl:Class ; rdfs:label "Abnormality of the kinin-kallikrein system" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0005560 obo:IAO_0000115 "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4025177" ; oboInOwl:hasExactSynonym "Imbalanced Hb synthesis", "Imbalanced haemoglobin synthesis" ; oboInOwl:id "HP:0005560" ; a owl:Class ; rdfs:comment "While imbalanced hemoglobin synthesis can be inferred from other findings including those of hemoglobin electrophoresis, the determination of this feature requires investigation of hemoglobin synthesis in vitro, e.g., by incubation of washed peripheral blood erythrocytes and bone marrow cells with radioactively labeled leucine followed by column chromatography." ; rdfs:label "Imbalanced hemoglobin synthesis" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0005561 obo:IAO_0000115 "An anomaly of the form or number of cells in the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T10:46:00Z" ; oboInOwl:hasDbXref "MSH:D001855", "SNOMEDCT_US:127035006", "UMLS:C0005956", "UMLS:C4021634" ; oboInOwl:hasExactSynonym "Anomaly of the bone marrow cells" ; oboInOwl:hasRelatedSynonym "Bone marrow disease" ; oboInOwl:id "HP:0005561" ; a owl:Class ; rdfs:label "Abnormality of bone marrow cell morphology" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0002092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005562 obo:IAO_0000115 "The presence of many cysts in the kidney." ; oboInOwl:hasDbXref "SNOMEDCT_US:253883006", "UMLS:C0431718" ; oboInOwl:hasExactSynonym "Multiple kidney cysts" ; oboInOwl:id "HP:0005562" ; a owl:Class ; rdfs:label "Multiple renal cysts" ; rdfs:subClassOf obo:HP_0000107 . obo:HP_0005563 obo:IAO_0000115 "A reduction in the count of nephrons per kidney." ; oboInOwl:hasDbXref "UMLS:C1841994", "UMLS:C2673888" ; oboInOwl:hasExactSynonym "Oligonephronia" ; oboInOwl:hasRelatedSynonym "Decreased numbers of glomeruli" ; oboInOwl:id "HP:0005563" ; a owl:Class ; rdfs:label "Decreased numbers of nephrons" ; rdfs:subClassOf obo:HP_0012575 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001285 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005564 obo:IAO_0000115 "A lack of differentiation between renal cortex and medulla on diagnostic imaging." ; oboInOwl:hasAlternativeId "HP:0005581" ; oboInOwl:hasDbXref "UMLS:C1849765" ; oboInOwl:hasExactSynonym "Absent renal corticomedullary differentiation", "Loss of corticomedullary differentiation" ; oboInOwl:id "HP:0005564" ; a owl:Class ; rdfs:label "Absence of renal corticomedullary differentiation" ; rdfs:subClassOf obo:HP_0005932 . obo:HP_0005565 obo:IAO_0000115 "Reduced differentiation between renal cortex and medulla on diagnostic imaging." ; oboInOwl:hasAlternativeId "HP:0005573" ; oboInOwl:hasDbXref "UMLS:C3807131" ; oboInOwl:hasExactSynonym "Loss of definition of corticomedullary differentiation" ; oboInOwl:id "HP:0005565" ; a owl:Class ; rdfs:label "Reduced renal corticomedullary differentiation" ; rdfs:subClassOf obo:HP_0005932 . obo:HP_0005567 obo:IAO_0000115 "High urine magnesium in the presence of hypomagnesemia." ; oboInOwl:hasDbXref "MSH:C537152", "UMLS:C1835171" ; oboInOwl:id "HP:0005567" ; a owl:Class ; rdfs:label "Renal magnesium wasting" ; rdfs:subClassOf obo:HP_0012607 . obo:HP_0005571 oboInOwl:hasDbXref "UMLS:C1968910" ; oboInOwl:hasExactSynonym "Increased percent tubular reabsorption of phosphorus" ; oboInOwl:id "HP:0005571" ; a owl:Class ; rdfs:label "Increased renal tubular phosphate reabsorption" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0005572 oboInOwl:hasDbXref "UMLS:C1968899" ; oboInOwl:id "HP:0005572" ; a owl:Class ; rdfs:label "Decreased renal tubular phosphate excretion" ; rdfs:subClassOf obo:HP_0011036 . obo:HP_0005574 obo:IAO_0000115 "A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption without bicarbonate loss." ; oboInOwl:hasDbXref "UMLS:C4025176" ; oboInOwl:id "HP:0005574" ; a owl:Class ; rdfs:label "Non-acidotic proximal tubulopathy" ; rdfs:subClassOf obo:HP_0000114 . obo:HP_0005575 obo:IAO_0000115 "A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease." ; oboInOwl:hasDbXref "MSH:D006463", "SNOMEDCT_US:111407006", "UMLS:C0019061" ; oboInOwl:hasExactSynonym "Hemolytic uremic syndrome" ; oboInOwl:id "HP:0005575" ; a owl:Class ; rdfs:label "Hemolytic-uremic syndrome" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0005576 obo:IAO_0000115 "A progressive detrimental connective tissue deposition (fibrosis) on the kidney parenchyma involving the tubules and interstitial tissue of the kidney. Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IF/TA) as the final common pathway. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation). For new annotations it is preferable to annotate to the specific HPO terms for Renal interstitial lfibrosis and/or Renal tubular atrophy." ; oboInOwl:hasAlternativeId "HP:0000129", "HP:0004714", "HP:0008171" ; oboInOwl:hasDbXref "UMLS:C1969372" ; oboInOwl:hasExactSynonym "Tubulointerstitial renal fibrosis" ; oboInOwl:hasRelatedSynonym "Tubulointerstitial scarring" ; oboInOwl:id "HP:0005576" ; a owl:Class ; rdfs:comment "This finding is usually shown by renal biopsy. Fibrosis involves an excess accumulation of extracellular matrix and usually results in loss of function when normal tissue is replaced with scar tissue. Tubulointerstitial renal fibrosis, characterized as a progressive detrimental connective tissue deposition on the kidney parenchyma, appears to be a harmful process leading inevitably to renal function deterioration, independently of the primary renal disease which causes the original kidney injury. Epithelial to Mesenchymal Transition (EMT) of tubular epithelial cells which are transformed to mesenchymal fibroblasts migrating to adjacent interstitial parenchyma constitutes the principal mechanism of renal fibrosis along with local and circulating cells. (PMID:20011086)" ; rdfs:label "Tubulointerstitial fibrosis" ; rdfs:subClassOf obo:HP_0001969, obo:HP_0030760 . obo:HP_0005579 obo:IAO_0000115 "Any impairment of reabsorption of chloride by the kidney in order to not lose too much chloride in the urine." ; oboInOwl:hasDbXref "UMLS:C1846349" ; oboInOwl:hasExactSynonym "Impaired reabsorption of Cl", "Impaired reabsorption of Cl-" ; oboInOwl:id "HP:0005579" ; a owl:Class ; rdfs:label "Impaired renal ltubular reabsorption of chloride" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0005580 obo:IAO_0000115 "A duplication of the renal pelvis." ; oboInOwl:hasDbXref "UMLS:C1839269" ; oboInOwl:id "HP:0005580" ; a owl:Class ; rdfs:label "Duplication of renal pelvis" ; rdfs:subClassOf obo:HP_0000075, obo:HP_0010944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005583 obo:IAO_0000115 "DIsruption and breaking up of the basement membrane of the tubules of the kidney." ; oboInOwl:hasAlternativeId "HP:0005577" ; oboInOwl:hasDbXref "UMLS:C1968618" ; oboInOwl:hasExactSynonym "Disintegration of the tubular basement membrane" ; oboInOwl:id "HP:0005583" ; a owl:Class ; rdfs:comment "Throughout the rest of the nephron, tubule epithelial cells are attached to the tubular basement membrane that overlies the subjacent interstitial connective tissue. The disruption of cell-basement membrane adhesion results in loss of cell orientation, abnormal cell function, and can lead to tissue destruction." ; rdfs:label "Tubular basement membrane disintegration" ; rdfs:subClassOf obo:HP_0020131 . obo:HP_0005584 obo:IAO_0000115 "A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule." ; oboInOwl:hasAlternativeId "HP:0006720" ; oboInOwl:hasDbXref "MSH:D002292", "NCIT:C2916", "SNOMEDCT_US:41607009", "SNOMEDCT_US:702391001", "UMLS:C0007134" ; oboInOwl:hasExactSynonym "Cancer starting in small tubes in kidneys", "Hypernephroma", "Renal carcinoma" ; oboInOwl:id "HP:0005584" ; a owl:Class ; rdfs:comment "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." ; rdfs:label "Renal cell carcinoma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0005585 oboInOwl:hasDbXref "UMLS:C3806179" ; oboInOwl:hasExactSynonym "Patchy hyperpigmentation", "Spotty increased pigmentation" ; oboInOwl:id "HP:0005585" ; a owl:Class ; rdfs:label "Spotty hyperpigmentation" ; rdfs:subClassOf obo:HP_0007400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000953 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0005586 oboInOwl:hasDbXref "UMLS:C3805877" ; oboInOwl:hasExactSynonym "Hyperpigmentation of exposed areas", "Increased pigmentation in sun-exposed areas" ; oboInOwl:id "HP:0005586" ; a owl:Class ; rdfs:label "Hyperpigmentation in sun-exposed areas" ; rdfs:subClassOf obo:HP_0000953 . obo:HP_0005587 oboInOwl:hasDbXref "UMLS:C1834424" ; oboInOwl:id "HP:0005587" ; a owl:Class ; rdfs:label "Profuse pigmented skin lesions" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0005588 obo:IAO_0000115 "A focal type of palmoplantar keratoderma in which only certain areas of the palms and soles are affected." ; oboInOwl:hasDbXref "UMLS:C4021633" ; oboInOwl:hasExactSynonym "Palmoplantar keratoderma, patchy", "Patchy palmoplantar keratoderma" ; oboInOwl:id "HP:0005588" ; a owl:Class ; rdfs:comment "Patchy palmoplantar keratoderma may develop at sites of recurrent friction." ; rdfs:label "Patchy palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0005590 oboInOwl:hasDbXref "UMLS:C3806178" ; oboInOwl:hasExactSynonym "Patchy depigmentation", "Patchy hypopigmentation", "Spotty decreased pigmentation" ; oboInOwl:id "HP:0005590" ; a owl:Class ; rdfs:label "Spotty hypopigmentation" ; rdfs:subClassOf obo:HP_0001053 . obo:HP_0005592 obo:IAO_0000115 "The presence of large spherical melanosomes (1 to 6 micrometer in diameter) in the cytoplasm of melanocytes." ; oboInOwl:hasAlternativeId "HP:0003342" ; oboInOwl:hasDbXref "UMLS:C3806221" ; oboInOwl:hasExactSynonym "Macromelanosomes" ; oboInOwl:id "HP:0005592" ; a owl:Class ; rdfs:comment "Giant melanosomes can be seen in cafe-au-lait spots and other melanocytic disorders. Giant melanosome and giant melanosome are synonymous. Macromelanosomes can be detected by electron microscopy of the skin." ; rdfs:label "Giant melanosomes in melanocytes" ; rdfs:subClassOf obo:HP_0011125 . obo:HP_0005593 oboInOwl:hasDbXref "UMLS:C3806616" ; oboInOwl:id "HP:0005593" ; a owl:Class ; rdfs:label "Macular hypopigmented whorls, streaks, and patches" ; rdfs:subClassOf obo:HP_0001053 . obo:HP_0005595 oboInOwl:hasDbXref "UMLS:C1969913" ; oboInOwl:hasExactSynonym "Generalised hyperkeratosis", "Hyperkeratosis, generalised", "Hyperkeratosis, generalized" ; oboInOwl:id "HP:0005595" ; a owl:Class ; rdfs:label "Generalized hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0005597 obo:IAO_0000115 "Loss of all scalp hair with congenital onset." ; oboInOwl:hasDbXref "UMLS:C4025175" ; oboInOwl:id "HP:0005597" ; a owl:Class ; rdfs:label "Congenital alopecia totalis" ; rdfs:subClassOf obo:HP_0007418 . obo:HP_0005598 obo:IAO_0000115 "Telangiectases (small dilated blood vessels) located near the surface of the skin in a butterfly midface distribution." ; oboInOwl:hasDbXref "UMLS:C4021632" ; oboInOwl:hasExactSynonym "Butterfly facial telangiectasia" ; oboInOwl:id "HP:0005598" ; a owl:Class ; rdfs:label "Facial telangiectasia in butterfly midface distribution" ; rdfs:subClassOf obo:HP_0007380 . obo:HP_0005599 oboInOwl:hasDbXref "UMLS:C3278401" ; oboInOwl:hasExactSynonym "Hair hypopigmentation", "Loss of hair color", "Loss of hair colour" ; oboInOwl:id "HP:0005599" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypopigmentation of hair" ; rdfs:subClassOf obo:HP_0009887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005600 obo:IAO_0000115 "The giant congenital nevus is greater than 8 cm in size, pigmented and often hairy. A giant congenital nevus is smaller in infants and children, but it usually continues to grow with the child." ; oboInOwl:hasAlternativeId "HP:0005604" ; oboInOwl:hasDbXref "MSH:C536819", "SNOMEDCT_US:10291008", "SNOMEDCT_US:254815002", "UMLS:C1842036" ; oboInOwl:hasExactSynonym "Giant pigmented hairy nevus", "Giant pigmented mole", "Giant pigmented nevus" ; oboInOwl:id "HP:0005600" ; a owl:Class ; rdfs:comment "Between 4% and 6% of these lesions will develop into a malignant melanoma." ; rdfs:label "Congenital giant melanocytic nevus" ; rdfs:subClassOf obo:HP_0000995 . obo:HP_0005602 oboInOwl:hasDbXref "UMLS:C3806428" ; oboInOwl:id "HP:0005602" ; a owl:Class ; rdfs:label "Progressive vitiligo" ; rdfs:subClassOf obo:HP_0001045 . obo:HP_0005603 oboInOwl:hasDbXref "UMLS:C3806415" ; oboInOwl:id "HP:0005603" ; a owl:Class ; rdfs:label "Numerous congenital melanocytic nevi" ; rdfs:subClassOf obo:HP_0000995 . obo:HP_0005605 obo:IAO_0000115 "Large hypermelanotic macules with jagged borders." ; oboInOwl:hasDbXref "UMLS:C4025174" ; oboInOwl:id "HP:0005605" ; a owl:Class ; rdfs:comment "This type of lesionk is observed in McCune Albright syndrome. The cafe-au-lait macules are larger than those seen in neurofibromatosis, and have more irregular borders. The borders of these macules have been compared to the coast of Maine, whereas the cafe-au-lait spots in neurofibromatosis type 1 have been compared to the coast of California." ; rdfs:label "Large cafe-au-lait macules with irregular margins" ; rdfs:subClassOf obo:HP_0001034 . obo:HP_0005606 oboInOwl:hasDbXref "UMLS:C3805692" ; oboInOwl:id "HP:0005606" ; a owl:Class ; rdfs:label "Hyperpigmented nevi and streak" ; rdfs:subClassOf obo:HP_0000995 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000498 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005607 dcterms:creator ; oboInOwl:creation_date "2008-03-28T09:03:00Z" ; oboInOwl:hasAlternativeId "HP:0005940" ; oboInOwl:hasDbXref "Fyler:4232", "UMLS:C4021631" ; oboInOwl:hasExactSynonym "Tracheobronchial anomalies" ; oboInOwl:id "HP:0005607" ; a owl:Class ; rdfs:label "Abnormal tracheobronchial morphology" ; rdfs:subClassOf obo:HP_0012252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005608 obo:IAO_0000115 "The presence of a bilobed gallbladder, related to a duplication of the gallbladder primordium." ; oboInOwl:hasDbXref "UMLS:C1846422" ; oboInOwl:hasExactSynonym "Bilobed gallbladder", "Double gallbladder", "Gallbladder duplication", "Gallbladder septated" ; oboInOwl:id "HP:0005608" ; a owl:Class ; rdfs:comment "During the fifth or early sixth embryonic week, occasionally, the gallbladder primordium bifurcates and results in duplication of gallbladder. Duplication results from a split primordium whilst a true accessory gallbladder results from an extra primordium. There are no specific symptoms or signs associated with multiple gallbladders." ; rdfs:label "Bilobate gallbladder" ; rdfs:subClassOf obo:HP_0034504 . obo:HP_0005609 oboInOwl:hasDbXref "SNOMEDCT_US:51047007", "UMLS:C0232769" ; oboInOwl:hasExactSynonym "Gallbladder dysfunction" ; oboInOwl:id "HP:0005609" ; a owl:Class ; rdfs:label "Gallbladder dysfunction" ; rdfs:subClassOf obo:HP_0012438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005612 oboInOwl:hasDbXref "UMLS:C4025173" ; oboInOwl:id "HP:0005612" ; a owl:Class ; rdfs:label "Arthrogryposis-like hand anomaly" ; rdfs:subClassOf obo:HP_0005684 . obo:HP_0005613 obo:IAO_0000115 "Absence or underdevelopment of the femur." ; oboInOwl:hasAlternativeId "HP:0006396", "HP:0006425" ; oboInOwl:hasDbXref "UMLS:C1851310" ; oboInOwl:hasExactSynonym "Absent/small thighbone", "Absent/underdeveloped thighbone", "Hypoplastic to absent femora", "Hypoplastic/aplastic femora" ; oboInOwl:id "HP:0005613" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the femur" ; rdfs:subClassOf obo:HP_0002823, obo:HP_0006493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005616 obo:IAO_0000115 "An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." ; oboInOwl:hasAlternativeId "HP:0002649", "HP:0005854" ; oboInOwl:hasDbXref "SNOMEDCT_US:123982003", "UMLS:C0545053" ; oboInOwl:hasExactSynonym "Advanced bone age", "Early bone maturation" ; oboInOwl:id "HP:0005616" ; a owl:Class ; rdfs:label "Accelerated skeletal maturation" ; rdfs:subClassOf obo:HP_0000927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070977 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004288 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005617 oboInOwl:hasDbXref "UMLS:C4021830" ; oboInOwl:id "HP:0005617" ; a owl:Class ; rdfs:label "Bilateral camptodactyly" ; rdfs:subClassOf obo:HP_0100490 . obo:HP_0005619 obo:IAO_0000115 "Hyperconvexity of the thoracolumbar spine producing a rounded or humped appearance." ; oboInOwl:hasAlternativeId "HP:0003439" ; oboInOwl:hasDbXref "UMLS:C1855418" ; oboInOwl:hasExactSynonym "Thoracolumbar gibbus", "Thoracolumbar gibbus deformity" ; oboInOwl:id "HP:0005619" ; a owl:Class ; rdfs:label "Thoracolumbar kyphosis" ; rdfs:subClassOf obo:HP_0002942, obo:HP_0100712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002808 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009568 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005620 obo:IAO_0000115 "The ability of the interphalangeal joints to move beyond their normal range of motion." ; oboInOwl:hasDbXref "UMLS:C4025172" ; oboInOwl:hasExactSynonym "Increased mobility of hinge joints" ; oboInOwl:id "HP:0005620" ; a owl:Class ; rdfs:label "Hypermobility of interphalangeal joints" ; rdfs:subClassOf obo:HP_0001382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006658 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005621 obo:IAO_0000115 "An anomalous trapezoidal appearance of a vertebral body. A trapezoid is a four-sided shape that has two sides that are parallel and two sides that are not parallel. In this case, the two lateral sides of the vertebra are parallel, and the top and the bottom are slanted with respect to each other such that the vertebra is shorter in the fron or back than on the other side." ; oboInOwl:hasDbXref "UMLS:C4025171" ; oboInOwl:hasExactSynonym "Trapezoidal shaped vertebral bodies", "Trapezoidal vertebral bodies" ; oboInOwl:id "HP:0005621" ; a owl:Class ; rdfs:comment "See Figure 1d in PMID:33247084." ; rdfs:label "Trapezoidal vertebral body" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002044 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005622 obo:IAO_0000115 "Increased cross-section (diameter) of the long bones. Note that widening may primarily affect specific regions of long bones (e.g., diaphysis or metaphysis), but this should be coded separately." ; oboInOwl:hasDbXref "UMLS:C4021630" ; oboInOwl:hasExactSynonym "Broad long bones", "Wide long bones", "Widened long bones" ; oboInOwl:id "HP:0005622" ; a owl:Class ; rdfs:label "Broad long bones" ; rdfs:subClassOf obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005623 obo:IAO_0000115 "Absent ossification of the calvaria (vault of the skull)." ; oboInOwl:hasDbXref "UMLS:C4021629" ; oboInOwl:hasExactSynonym "Absent bone maturation of skullcap", "Absent ossification of skull vault" ; oboInOwl:id "HP:0005623" ; a owl:Class ; rdfs:label "Absent ossification of calvaria" ; rdfs:subClassOf obo:HP_0005474 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004339 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005625 obo:IAO_0000115 "Osteoporosis affecting predominantly the vertebrae." ; oboInOwl:hasDbXref "UMLS:C4025170" ; oboInOwl:id "HP:0005625" ; a owl:Class ; rdfs:label "Osteoporosis of vertebrae" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0040161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0005626 obo:IAO_0000115 "Bony fusion of the posterior part of the L5 vertebral body with the sacrum." ; oboInOwl:hasDbXref "UMLS:C4025169" ; oboInOwl:id "HP:0005626" ; a owl:Class ; rdfs:label "Posterior fusion of lumbosacral vertebrae" ; rdfs:subClassOf obo:HP_0002948 . obo:HP_0005627 obo:IAO_0000115 "This type of brachydactyly is characterized by short and broad terminal phalanges of the thumbs and big toes." ; oboInOwl:hasDbXref "MSH:C562420", "UMLS:C0220664" ; oboInOwl:hasExactSynonym "Brachydactyly type D" ; oboInOwl:id "HP:0005627" ; a owl:Class ; rdfs:label "Type D brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0005632 oboInOwl:hasDbXref "UMLS:C1408532" ; oboInOwl:hasExactSynonym "Absent forearm" ; oboInOwl:hasRelatedSynonym "Absent forearms" ; oboInOwl:id "HP:0005632" ; a owl:Class ; rdfs:label "Absent forearm" ; rdfs:subClassOf obo:HP_0002973 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005638 oboInOwl:hasDbXref "UMLS:C4025168" ; oboInOwl:id "HP:0005638" ; a owl:Class ; rdfs:label "Decreased anterioposterior diameter of lumbar vertebral bodies" ; rdfs:subClassOf obo:HP_0008473 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005639 obo:IAO_0000115 "The ability of the joints of the hand to move beyond their normal range of motion." ; oboInOwl:hasDbXref "UMLS:C1856877" ; oboInOwl:id "HP:0005639" ; a owl:Class ; rdfs:label "Hyperextensible hand joints" ; rdfs:subClassOf obo:HP_0001382 . obo:HP_0005640 oboInOwl:hasDbXref "UMLS:C4025167" ; oboInOwl:id "HP:0005640" ; a owl:Class ; rdfs:label "Abnormal vertebral segmentation and fusion" ; rdfs:subClassOf obo:HP_0002948 . obo:HP_0005643 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the third toe." ; oboInOwl:hasDbXref "UMLS:C4021628" ; oboInOwl:hasExactSynonym "Brachydactyly of third toes", "Short 3rd toe", "Short third toe" ; oboInOwl:id "HP:0005643" ; a owl:Class ; rdfs:label "Short 3rd toe" ; rdfs:subClassOf obo:HP_0001831 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005645 obo:IAO_0000115 "The presence of abnormal calcium deposition of the intervertebral disk." ; oboInOwl:hasDbXref "SNOMEDCT_US:240211000", "UMLS:C0410607" ; oboInOwl:hasExactSynonym "Intervertebral disc calcification", "Multiple intervertebral disc calcifications", "Multiple intervertebral disk calcifications" ; oboInOwl:id "HP:0005645" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Intervertebral disk calcification" ; rdfs:subClassOf obo:HP_0005108, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005648 obo:IAO_0000115 "Underdevelopment of the ulna on both sides." ; oboInOwl:hasDbXref "UMLS:C4025166" ; oboInOwl:id "HP:0005648" ; a owl:Class ; rdfs:comment "May be a symmetric finding." ; rdfs:label "Bilateral ulnar hypoplasia" ; rdfs:subClassOf obo:HP_0003022 . obo:HP_0005650 obo:IAO_0000115 "A soft tissue continuity in the anteroposterior axis between the second to the fifth fingers that extends distally to at least the level of the proximal interphalangeal joints." ; oboInOwl:hasDbXref "UMLS:C4025165" ; oboInOwl:hasExactSynonym "Cutaneous syndactyly between fingers 2 and 5" ; oboInOwl:id "HP:0005650" ; a owl:Class ; rdfs:label "2-5 finger cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010554 . obo:HP_0005652 obo:IAO_0000115 "Sclerosis (abnormal hardening) of cortical bone, characterized by increased radiodensity." ; oboInOwl:hasDbXref "UMLS:C4025164" ; oboInOwl:id "HP:0005652" ; a owl:Class ; rdfs:label "Cortical sclerosis" ; rdfs:subClassOf obo:HP_0003103, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001439 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005653 obo:IAO_0000115 "Moderate osteoporosis." ; oboInOwl:hasDbXref "UMLS:C4025163" ; oboInOwl:hasExactSynonym "Moderate generalised osteoporosis" ; oboInOwl:id "HP:0005653" ; a owl:Class ; rdfs:label "Moderate generalized osteoporosis" ; rdfs:subClassOf obo:HP_0040160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0040160 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005655 obo:IAO_0000115 "Multiple exostoses originating in the fingers and toes." ; oboInOwl:hasDbXref "UMLS:C4025162" ; oboInOwl:id "HP:0005655" ; a owl:Class ; rdfs:comment "This feature is characteristic of metachondromatosis (MIM:156250)." ; rdfs:label "Multiple digital exostoses" ; rdfs:subClassOf obo:HP_0002762 . obo:HP_0005656 obo:IAO_0000115 "A foot deformity resulting due to an abnormality affecting the muscle and soft tissue. In contrast if the bones of the foot are affected the term structural foot deformity applies." ; oboInOwl:hasDbXref "UMLS:C4025161" ; oboInOwl:id "HP:0005656" ; a owl:Class ; rdfs:label "Positional foot deformity" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0005659 oboInOwl:hasDbXref "UMLS:C4015465" ; oboInOwl:id "HP:0005659" ; a owl:Class ; rdfs:label "Thoracic kyphoscoliosis" ; rdfs:subClassOf obo:HP_0002943 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002751 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005661 obo:IAO_0000115 "Osteomyelitis caused by infection with the bacteria, salmonella." ; oboInOwl:hasDbXref "SNOMEDCT_US:6803002", "UMLS:C0152491" ; oboInOwl:hasExactSynonym "Salmonella bone infection" ; oboInOwl:id "HP:0005661" ; a owl:Class ; rdfs:label "Salmonella osteomyelitis" ; rdfs:subClassOf obo:HP_0002754 . obo:HP_0005665 obo:IAO_0000115 "Extreme thickening of the cortex of long bones." ; oboInOwl:hasDbXref "UMLS:C4025160" ; oboInOwl:id "HP:0005665" ; a owl:Class ; rdfs:label "Massively thickened long bone cortices" ; rdfs:subClassOf obo:HP_0000935 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0005667 obo:IAO_0000115 "Separation of the odontoid process from the body of the axis." ; oboInOwl:hasDbXref "SNOMEDCT_US:445242006", "UMLS:C2919848" ; oboInOwl:id "HP:0005667" ; a owl:Class ; rdfs:comment "With os odontoideum, the caudal fragment of the odontoid process may provide deficient stability for the atlantoaxial joint and lead to subsequent instability or dislocation and neurological deficits." ; rdfs:label "Os odontoideum" ; rdfs:subClassOf obo:HP_0003310 . obo:HP_0005671 obo:IAO_0000115 "Deposition of calcium salts on both sides of the brain." ; oboInOwl:hasDbXref "UMLS:C4025159" ; oboInOwl:hasExactSynonym "Bilateral intracranial calcifications" ; oboInOwl:id "HP:0005671" ; a owl:Class ; rdfs:label "Bilateral intracerebral calcifications" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0005676 oboInOwl:hasDbXref "UMLS:C4025158" ; oboInOwl:id "HP:0005676" ; a owl:Class ; rdfs:label "Rudimentary postaxial polydactyly of hands" ; rdfs:subClassOf obo:HP_0001162 . obo:HP_0005678 oboInOwl:hasDbXref "UMLS:C4025157" ; oboInOwl:id "HP:0005678" ; a owl:Class ; rdfs:label "Anterior atlanto-occipital dislocation" ; rdfs:subClassOf obo:HP_0003414 . obo:HP_0005679 obo:IAO_0000115 "An abnormality of the hand resulting from contracture of the palmar fascia with a fixed flexion deformity of the metacarpophalangeal (MCP) joints and the proximal interphalangeal (PIP) joints." ; oboInOwl:hasDbXref "MSH:D004387", "SNOMEDCT_US:203045001", "SNOMEDCT_US:203047009", "SNOMEDCT_US:274142002", "SNOMEDCT_US:410813000", "UMLS:C0013312" ; oboInOwl:id "HP:0005679" ; a owl:Class ; rdfs:comment "A Dupuytren contracture usually affects the fourth and fifth digits (the ring and small fingers). Affected persons are not able to extend the 4th and 5th fingers." ; rdfs:label "Dupuytren contracture" ; rdfs:subClassOf obo:HP_0009473 . obo:HP_0005680 obo:IAO_0000115 "A tongue-like protusion from the anterior aspect of lumbar vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C4025156" ; oboInOwl:id "HP:0005680" ; a owl:Class ; rdfs:label "Tongue-like lumbar vertebral deformities" ; rdfs:subClassOf obo:HP_0008430 . obo:HP_0005681 oboInOwl:hasDbXref "SNOMEDCT_US:410795001", "UMLS:C3714757" ; oboInOwl:hasExactSynonym "Juvenile RA", "Juvenile idiopathic arthritis", "Rheumatoid arthritis, juvenile" ; oboInOwl:id "HP:0005681" ; a owl:Class ; rdfs:label "Juvenile rheumatoid arthritis" ; rdfs:subClassOf obo:HP_0001370 . obo:HP_0005682 oboInOwl:hasBroadSynonym "Fusion of foot joint" ; oboInOwl:hasDbXref "UMLS:C4025155", "UMLS:C4255214" ; oboInOwl:hasExactSynonym "Fusion of the subtalar joint" ; oboInOwl:id "HP:0005682" ; a owl:Class ; rdfs:label "Talocalcaneal synostosis" ; rdfs:subClassOf obo:HP_0008368 . obo:HP_0005684 obo:IAO_0000115 "An inherited primary limb malformation disorder characterized by congenital contractures of two or more different body areas and without primary neurologic and/or muscle disease that affects limb function." ; oboInOwl:hasDbXref "SNOMEDCT_US:24269006", "UMLS:C0265213" ; oboInOwl:id "HP:0005684" ; a owl:Class ; rdfs:label "Distal arthrogryposis" ; rdfs:subClassOf obo:HP_0002803 . obo:HP_0005686 obo:IAO_0000115 "Patchy (irregular) increase in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C1855845" ; oboInOwl:hasExactSynonym "Patchy increase of bone mineral density", "Uneven increase in bone density" ; oboInOwl:id "HP:0005686" ; a owl:Class ; rdfs:label "Patchy osteosclerosis" ; rdfs:subClassOf obo:HP_0010658, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0011001 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0005687 oboInOwl:hasDbXref "UMLS:C4025154" ; oboInOwl:hasExactSynonym "Deformed head of long bone in upper arm" ; oboInOwl:id "HP:0005687" ; a owl:Class ; rdfs:label "Deformed humeral heads" ; rdfs:subClassOf obo:HP_0003871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005688 oboInOwl:hasDbXref "UMLS:C4025153" ; oboInOwl:id "HP:0005688" ; a owl:Class ; rdfs:label "Dysplastic distal thumb phalanges with a central hole" ; rdfs:subClassOf obo:HP_0009617 . obo:HP_0005689 oboInOwl:hasDbXref "UMLS:C4025152" ; oboInOwl:id "HP:0005689" ; a owl:Class ; rdfs:label "Dermatoglyphic ridges abnormal" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0005692 obo:IAO_0000115 "Increased mobility and flexibility in the joint due to the tension in tissues such as ligaments and muscles." ; oboInOwl:hasDbXref "UMLS:C3553764" ; oboInOwl:hasExactSynonym "Joints move beyond expected range of motion" ; oboInOwl:id "HP:0005692" ; a owl:Class ; rdfs:label "Joint hyperflexibility" ; rdfs:subClassOf obo:HP_0001382 . obo:HP_0005694 oboInOwl:hasBroadSynonym "Partial fusion of innermost row of wrist bones" ; oboInOwl:hasDbXref "UMLS:C3152021" ; oboInOwl:id "HP:0005694" ; a owl:Class ; rdfs:label "Partial fusion of proximal row of carpal bones" ; rdfs:subClassOf obo:HP_0009702 . obo:HP_0005696 obo:IAO_0000115 "Supernumerary digits located at the ulnar side of the hand with a complete extra finger and extra metacarpal." ; oboInOwl:hasDbXref "MSH:C562429", "SNOMEDCT_US:715704001", "UMLS:C3887487" ; oboInOwl:id "HP:0005696" ; a owl:Class ; rdfs:label "Postaxial polydactyly type A" ; rdfs:subClassOf obo:HP_0001162 . obo:HP_0005700 oboInOwl:hasDbXref "UMLS:C4025151" ; oboInOwl:id "HP:0005700" ; a owl:Class ; rdfs:label "Increased bone density with cystic changes" ; rdfs:subClassOf obo:HP_0011001 . obo:HP_0005701 oboInOwl:hasDbXref "MSH:D004687", "SNOMEDCT_US:268274005", "UMLS:C0014084" ; oboInOwl:id "HP:0005701" ; a owl:Class ; rdfs:label "Multiple enchondromatosis" ; rdfs:subClassOf obo:HP_0002763, obo:HP_0030038 . obo:HP_0005707 obo:IAO_0000115 "A bilateral form of triphalangeal thumb." ; oboInOwl:hasDbXref "UMLS:C4021627" ; oboInOwl:hasExactSynonym "Bilateral digitalized thumb" ; oboInOwl:id "HP:0005707" ; a owl:Class ; rdfs:label "Bilateral triphalangeal thumbs" ; rdfs:subClassOf obo:HP_0001199 . obo:HP_0005709 oboInOwl:hasDbXref "SNOMEDCT_US:205145001", "UMLS:C0432040" ; oboInOwl:hasExactSynonym "Complete cutaneous syndactyly of second and third toes", "Cutaneous 2,3 toe syndactyly", "Cutaneous syndactyly of second and third toes", "Webbed skin of 2nd-3rd toes" ; oboInOwl:id "HP:0005709" ; a owl:Class ; rdfs:label "2-3 toe cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010621 . obo:HP_0005715 oboInOwl:hasDbXref "UMLS:C4025150" ; oboInOwl:hasExactSynonym "Flattened end part of knee bone" ; oboInOwl:id "HP:0005715" ; a owl:Class ; rdfs:label "Flattened knee epiphyses" ; rdfs:subClassOf obo:HP_0003071, obo:HP_0034669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005716 oboInOwl:hasAlternativeId "HP:0008898" ; oboInOwl:hasDbXref "UMLS:C4021626" ; oboInOwl:hasExactSynonym "Lethal dwarfism identifiable at birth" ; oboInOwl:id "HP:0005716" ; a owl:Class ; rdfs:label "Lethal skeletal dysplasia" ; rdfs:subClassOf obo:HP_0002652 . obo:HP_0005720 obo:IAO_0000115 "Abnormal reduction in length of all metacarpal bones." ; oboInOwl:hasDbXref "UMLS:C4025149" ; oboInOwl:id "HP:0005720" ; a owl:Class ; rdfs:label "Shortening of all metacarpals" ; rdfs:subClassOf obo:HP_0010049 . obo:HP_0005722 obo:IAO_0000115 "The ability of the thumb joints to move beyond their normal range of motion." ; oboInOwl:hasDbXref "UMLS:C4025148" ; oboInOwl:hasExactSynonym "Double jointed thumb" ; oboInOwl:id "HP:0005722" ; a owl:Class ; rdfs:label "Hyperextensible thumb" ; rdfs:subClassOf obo:HP_0005639 . obo:HP_0005723 oboInOwl:hasDbXref "UMLS:C4025147" ; oboInOwl:id "HP:0005723" ; a owl:Class ; rdfs:label "Shoe-shaped sella turcica" ; rdfs:subClassOf obo:HP_0002681 . obo:HP_0005725 obo:IAO_0000115 "A form of triphalangeal thumb that cannot be placed opposite the fingers of the same hand." ; oboInOwl:hasDbXref "MSH:C536562", "UMLS:C2931238" ; oboInOwl:id "HP:0005725" ; a owl:Class ; rdfs:label "Nonopposable triphalangeal thumb" ; rdfs:subClassOf obo:HP_0001199 . obo:HP_0005726 oboInOwl:hasDbXref "UMLS:C4025146" ; oboInOwl:hasExactSynonym "Short thumbs with bulbous tips" ; oboInOwl:id "HP:0005726" ; a owl:Class ; rdfs:label "Thumbs hypoplastic with bulbous tips" ; rdfs:subClassOf obo:HP_0009778 . obo:HP_0005731 obo:IAO_0000115 "An abnormal irregularity of cortical bone." ; oboInOwl:hasDbXref "UMLS:C4025145" ; oboInOwl:id "HP:0005731" ; a owl:Class ; rdfs:label "Cortical irregularity" ; rdfs:subClassOf obo:HP_0003103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001439 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005733 obo:IAO_0000115 "An abnormal narrowing of the spinal canal related to a reduction in the interpedicular distance (i.e., the distance measured between the pedicles on frontal [coronal] imaging)." ; oboInOwl:hasAlternativeId "HP:0004597" ; oboInOwl:hasDbXref "UMLS:C4021625" ; oboInOwl:hasExactSynonym "Spinal stenosis due to short pedicles" ; oboInOwl:id "HP:0005733" ; a owl:Class ; rdfs:comment "The pedicles are two short, thick processes that connect the body of the vertebrae to the arch." ; rdfs:label "Spinal stenosis with reduced interpedicular distance" ; rdfs:subClassOf obo:HP_0003416 . obo:HP_0005736 obo:IAO_0000115 "Underdevelopment (reduced size) of the tibia." ; oboInOwl:hasAlternativeId "HP:0002993", "HP:0006436", "HP:0006445" ; oboInOwl:hasDbXref "UMLS:C1850259", "UMLS:C1855277" ; oboInOwl:hasExactSynonym "Hypoplasia of the tibia", "Hypoplastic tibia", "Short shinbone", "Short skankbone", "Short tibiae", "Shortening of the shankbone", "Shortening of the shinbone", "Shortening of the tibia" ; oboInOwl:id "HP:0005736" ; a owl:Class ; rdfs:label "Short tibia" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0005772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005739 obo:IAO_0000115 "Partial dislocation of the head of the radius in the posterior direction." ; oboInOwl:hasDbXref "UMLS:C3149878" ; oboInOwl:id "HP:0005739" ; a owl:Class ; rdfs:label "Posterior subluxation of radial head" ; rdfs:subClassOf obo:HP_0003048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001922 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005743 obo:IAO_0000115 "Avascular necrosis of the proximal epiphysis of the femur occurring in growing children and caused by an interruption of the blood supply to the head of the femur close to the hip joint. The necrosis is characteristically associated with flattening of the femoral head, for which reason the term coxa plana has been used to refer to this feature in the medical literature." ; oboInOwl:hasAlternativeId "HP:0003280", "HP:0006448", "HP:0010887" ; oboInOwl:hasDbXref "ICD-10:M91.1", "MSH:D007873", "SNOMEDCT_US:111255008", "SNOMEDCT_US:240241003", "UMLS:C0023234" ; oboInOwl:hasExactSynonym "Osteochondrosis of the femoral head", "Osteonecrosis of the femoral head", "Perthes-like femoral head changes" ; oboInOwl:hasRelatedSynonym "Coxa plana", "Legg-Calve-Perthes syndrome", "Legg-Perthes disease", "Morbus Legg-Calve-Perthes" ; oboInOwl:id "HP:0005743" ; a owl:Class ; rdfs:comment "In medical parlance, this is often referred to as Legg Calve Perthes disease. Here, the name 'Avascular necrosis of the capital femoral epiphysis' is preferred to emphasize that the term refers to a phenotypic feature rather than a disease entity. Avascular necrosis of the femoral head may result in pain in the hip, limp, stiffness and reduced range of motion, and some degree of atrophy of the affected leg. The phrase Legg Perthes syndrome or Legg Calve Perthes disease is also used to refer to a number of diseases, including the idiopathic form and a form that is related to mutation in the COL2A1 gene (MIM 150600). Legg-Calve-Perthes disease usually occurs in boys 4 to 10 years old, and is clinically characterized by limping, hip stiffness, limited range of motion, and can result in restriction of growth of the affected leg and wasting of the muscles of the upper thigh." ; rdfs:label "Avascular necrosis of the capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0010574, obo:HP_0100323 . obo:HP_0005744 obo:IAO_0100001 "HP:0040160" ; oboInOwl:id "HP:0005744" ; a owl:Class ; rdfs:label "obsolete Generalized osteoporosis with pathologic fractures" ; owl:deprecated true . obo:HP_0005745 oboInOwl:hasDbXref "UMLS:C4025144" ; oboInOwl:id "HP:0005745" ; a owl:Class ; rdfs:label "Congenital foot contractures" ; rdfs:subClassOf obo:HP_0002803, obo:HP_0005750 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002803 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005746 obo:IAO_0000115 "An increase in bone density affecting the basicranium (base of the skull)." ; oboInOwl:hasDbXref "UMLS:C4021624" ; oboInOwl:hasExactSynonym "Osteosclerosis of the skull base" ; oboInOwl:id "HP:0005746" ; a owl:Class ; rdfs:comment "Bundled term. Consider obsoleting it and splitting of osteosclerosis of base of skull." ; rdfs:label "Osteosclerosis of the base of the skull" ; rdfs:subClassOf obo:HP_0005464 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002517 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005747 oboInOwl:hasDbXref "UMLS:C4025143" ; oboInOwl:id "HP:0005747" ; a owl:Class ; rdfs:label "Easily subluxated first metacarpophalangeal joints" ; rdfs:subClassOf obo:HP_0004294 . obo:HP_0005750 obo:IAO_0000115 "A limitation in the passive range of motion of a joint of the lower limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin." ; oboInOwl:hasDbXref "UMLS:C1859523" ; oboInOwl:hasExactSynonym "Contractures of the joints of the lower limbs", "Contractures, lower limbs" ; oboInOwl:id "HP:0005750" ; a owl:Class ; rdfs:label "Lower-limb joint contracture" ; rdfs:subClassOf obo:HP_0003121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005752 oboInOwl:hasDbXref "UMLS:C4025142" ; oboInOwl:id "HP:0005752" ; a owl:Class ; rdfs:label "Flattened moderately deformed vertebrae" ; rdfs:subClassOf obo:HP_0000926 . obo:HP_0005756 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses during the neonatal period." ; oboInOwl:hasDbXref "UMLS:C4021623" ; oboInOwl:hasExactSynonym "Epiphyseal stippling in neonates", "Speckled calcifications in bone end parts in neonates" ; oboInOwl:id "HP:0005756" ; a owl:Class ; rdfs:label "Neonatal epiphyseal stippling" ; rdfs:subClassOf obo:HP_0010655 . obo:HP_0005758 obo:IAO_0000115 "Abnormal elevation of the floor of the posterior fossa including occipital condyles and foramen magnum." ; oboInOwl:hasDbXref "MSH:D010985", "SNOMEDCT_US:86587003", "UMLS:C0032209" ; oboInOwl:id "HP:0005758" ; a owl:Class ; rdfs:label "Basilar impression" ; rdfs:subClassOf obo:HP_0000932 . obo:HP_0005759 obo:IAO_0000115 "An abnormally small and flat configuration of the posterior cranial fossa." ; oboInOwl:hasDbXref "UMLS:C4025141" ; oboInOwl:hasExactSynonym "Small and flat posterior fossa of skull", "Small and flat posterior skull bones" ; oboInOwl:id "HP:0005759" ; a owl:Class ; rdfs:label "Small flat posterior fossa" ; rdfs:subClassOf obo:HP_0040010, obo:HP_0040011 . obo:HP_0005764 oboInOwl:hasDbXref "MSH:D001168", "SNOMEDCT_US:416956002", "SNOMEDCT_US:417373000", "UMLS:C0162323" ; oboInOwl:id "HP:0005764" ; a owl:Class ; rdfs:label "Polyarticular arthritis" ; rdfs:subClassOf obo:HP_0005195 . obo:HP_0005765 oboInOwl:hasDbXref "SNOMEDCT_US:95478002", "UMLS:C0521556" ; oboInOwl:id "HP:0005765" ; a owl:Class ; rdfs:label "Sacral meningocele" ; rdfs:subClassOf obo:HP_0005107 . obo:HP_0005766 oboInOwl:hasDbXref "UMLS:C3806516" ; oboInOwl:hasExactSynonym "Disproportionate shortening of the shankbone", "Disproportionate shortening of the shinbone", "Marked shortening of tibia" ; oboInOwl:id "HP:0005766" ; a owl:Class ; rdfs:label "Disproportionate shortening of the tibia" ; rdfs:subClassOf obo:HP_0005736 . obo:HP_0005767 oboInOwl:hasDbXref "UMLS:C4025140" ; oboInOwl:id "HP:0005767" ; a owl:Class ; rdfs:label "1-2 toe complete cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010621 . obo:HP_0005768 obo:IAO_0000115 "A soft tissue continuity in the anteroposterior axis between the toes 2, 3, and 4." ; oboInOwl:hasDbXref "UMLS:C4021622" ; oboInOwl:hasExactSynonym "Soft tissue syndactyly of toes 2, 3, and 4", "Webbed 2nd, 3rd and 4th toes", "Webbed second, third and fourth toes" ; oboInOwl:id "HP:0005768" ; a owl:Class ; rdfs:label "2-4 toe cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010621 . obo:HP_0005769 obo:IAO_0000115 "Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger)." ; oboInOwl:hasBroadSynonym "Curvature of outermost bone of little finger", "Curvature of outermost bone of pinkie finger", "Curvature of outermost bone of pinky finger" ; oboInOwl:hasDbXref "UMLS:C4025139", "UMLS:C4280477" ; oboInOwl:id "HP:0005769" ; a owl:Class ; rdfs:label "Fifth finger distal phalanx clinodactyly" ; rdfs:subClassOf obo:HP_0004209, obo:HP_0004225 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005772 obo:IAO_0000115 "Absence or underdevelopment of the tibia." ; oboInOwl:hasDbXref "UMLS:C1969181" ; oboInOwl:hasExactSynonym "Absent/hypoplastic tibia", "Absent/small shankbone", "Absent/small shinbone", "Absent/underdeveloped shankbone", "Absent/underdeveloped shinbone", "Aplastic/hypoplastic tibia" ; oboInOwl:id "HP:0005772" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the tibia" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0006493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005773 obo:IAO_0000115 "Underdevelopment of both forearm bones, the ulna and the radius, resulting in a shortened forearm." ; oboInOwl:hasDbXref "UMLS:C1855299" ; oboInOwl:hasExactSynonym "Short forearm" ; oboInOwl:id "HP:0005773" ; a owl:Class ; rdfs:label "Short forearm" ; rdfs:subClassOf obo:HP_0009821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005775 oboInOwl:hasDbXref "UMLS:C4025138" ; oboInOwl:id "HP:0005775" ; a owl:Class ; rdfs:label "Multiple skeletal anomalies" ; rdfs:subClassOf obo:HP_0002652 . obo:HP_0005776 oboInOwl:hasDbXref "UMLS:C4025137" ; oboInOwl:id "HP:0005776" ; a owl:Class ; rdfs:label "Carpal bone malsegmentation" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035282 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005780 obo:IAO_0000115 "Absence of the distal interphalangeal flexion creases of the fourth finger." ; oboInOwl:hasDbXref "UMLS:C4021621" ; oboInOwl:hasExactSynonym "No fourth finger distal interphalangeal crease" ; oboInOwl:id "HP:0005780" ; a owl:Class ; rdfs:label "Absent fourth finger distal interphalangeal crease" ; rdfs:subClassOf obo:HP_0001032 . obo:HP_0005781 oboInOwl:hasDbXref "UMLS:C1859698" ; oboInOwl:id "HP:0005781" ; a owl:Class ; rdfs:label "Contractures of the large joints" ; rdfs:subClassOf obo:HP_0001371 . obo:HP_0005787 obo:IAO_0000115 "A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the lumbar spine." ; oboInOwl:hasAlternativeId "HP:0004588" ; oboInOwl:hasDbXref "UMLS:C4025136" ; oboInOwl:id "HP:0005787" ; a owl:Class ; rdfs:label "Lumbar platyspondyly" ; rdfs:subClassOf obo:HP_0000926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005788 oboInOwl:hasDbXref "UMLS:C4025135" ; oboInOwl:id "HP:0005788" ; a owl:Class ; rdfs:label "Abnormal cervical myelogram" ; rdfs:subClassOf obo:HP_0002318 . obo:HP_0005789 obo:IAO_0000115 "An abnormal increase of bone mineral density with generalized involvement of the skeleton." ; oboInOwl:hasAlternativeId "HP:0005805" ; oboInOwl:hasBroadSynonym "Increased bone density in skeletal bones" ; oboInOwl:hasDbXref "UMLS:C1843331", "UMLS:C4280476" ; oboInOwl:hasExactSynonym "Diffuse, symmetrical osteosclerosis", "Generalised osteosclerosis", "Osteosclerosis, diffuse symmetrical" ; oboInOwl:id "HP:0005789" ; a owl:Class ; rdfs:label "Generalized osteosclerosis" ; rdfs:subClassOf obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0005790 oboInOwl:hasDbXref "UMLS:C4025134", "UMLS:C4280474", "UMLS:C4280475" ; oboInOwl:hasExactSynonym "Bilateral hypoplasia of condylar process of mandible", "Bilateral hypoplasia of mandibular condylar head", "Bilateral hypoplasia of mandibular condylar neck", "Decreased height of condylar process of mandible", "Decreased length of condylar process of mandible", "Short condylar process of mandible" ; oboInOwl:hasNarrowSynonym "Short condylar head of mandible", "Short condylar neck of mandible" ; oboInOwl:id "HP:0005790" ; a owl:Class ; rdfs:label "Short mandibular condyles" ; rdfs:subClassOf obo:HP_0003778, obo:HP_3000077 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005791 obo:IAO_0000115 "Abnormal thickening of the cortex of the diaphyseal region of long bones." ; oboInOwl:hasDbXref "UMLS:C4025133" ; oboInOwl:id "HP:0005791" ; a owl:Class ; rdfs:label "Cortical thickening of long bone diaphyses" ; rdfs:subClassOf obo:HP_0000935, obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016422 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005792 obo:IAO_0000115 "Underdevelopment of the humerus." ; oboInOwl:hasAlternativeId "HP:0002989", "HP:0003014", "HP:0003064", "HP:0006419", "HP:0006464", "HP:0006468" ; oboInOwl:hasDbXref "UMLS:C1832117" ; oboInOwl:hasExactSynonym "Humeral hypoplasia", "Humeral shortening", "Hypoplastic humerus", "Short humeri", "Short humerus", "Short long bone of upper arm", "Short upper arms" ; oboInOwl:id "HP:0005792" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short humerus" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0006507 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005793 obo:IAO_0000115 "Abnormally short distal phalanx of toe of all toes." ; oboInOwl:hasDbXref "UMLS:C4025132" ; oboInOwl:hasExactSynonym "Shortening of all outermost bone of the toes" ; oboInOwl:id "HP:0005793" ; a owl:Class ; rdfs:label "Shortening of all distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0001857 . obo:HP_0005794 obo:IAO_0100001 "HP:0004950" ; oboInOwl:id "HP:0005794" ; a owl:Class ; rdfs:label "obsolete Arterial disease of legs" ; owl:deprecated true . obo:HP_0005798 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint in an posterior direction." ; oboInOwl:hasDbXref "MSH:C566728", "UMLS:C1867398" ; oboInOwl:id "HP:0005798" ; a owl:Class ; rdfs:label "Posterior radial head dislocation" ; rdfs:subClassOf obo:HP_0003083 . obo:HP_0005802 oboInOwl:hasDbXref "UMLS:C4025130" ; oboInOwl:id "HP:0005802" ; a owl:Class ; rdfs:label "Coalescence of tarsal bones" ; rdfs:subClassOf obo:HP_0008368 . obo:HP_0005807 obo:IAO_0000115 "Aplasia (absence) of the distal phalanges." ; oboInOwl:hasDbXref "UMLS:C1861339" ; oboInOwl:hasExactSynonym "Absent outermost digital bones" ; oboInOwl:id "HP:0005807" ; a owl:Class ; rdfs:label "Absent distal phalanges" ; rdfs:subClassOf obo:HP_0009835 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005815 obo:IAO_0000115 "The presence of more than 12 rib pairs." ; oboInOwl:hasAlternativeId "HP:0000901" ; oboInOwl:hasDbXref "SNOMEDCT_US:205460009", "UMLS:C0345397" ; oboInOwl:hasExactSynonym "Extra ribs" ; oboInOwl:id "HP:0005815" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Supernumerary ribs" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0009144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005817 obo:IAO_0000115 "Combined syndactyly and polydactyly of the foot on the lateral side (i.e., on the side of the little toe)." ; oboInOwl:hasDbXref "UMLS:C4021824" ; oboInOwl:id "HP:0005817" ; a owl:Class ; rdfs:label "Postaxial polysyndactyly of foot" ; rdfs:subClassOf obo:HP_0001830 . obo:HP_0005819 obo:IAO_0000115 "Short (hypoplastic) middle phalanx of finger, affecting one or more fingers." ; oboInOwl:hasAlternativeId "HP:0001208", "HP:0006068", "HP:0006081", "HP:0010240" ; oboInOwl:hasDbXref "UMLS:C1846950" ; oboInOwl:hasExactSynonym "Brachymesophalangy", "Disproportionately short middle phalanges", "Hypoplasia of the middle phalanges of the hand", "Hypoplastic middle phalanges", "Hypoplastic middle phalanx", "Midphalangeal hypoplasia", "Short middle bone of finger", "Short middle phalanges", "Shortened middle finger bones" ; oboInOwl:id "HP:0005819" ; a owl:Class ; rdfs:label "Short middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009381, obo:HP_0009803, obo:HP_0009843 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005820 oboInOwl:hasDbXref "UMLS:C4025129" ; oboInOwl:id "HP:0005820" ; a owl:Class ; rdfs:label "Superior rib anomalies" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0005824 obo:IAO_0000115 "Bending or curvature of a second toe in the tibial direction (i.e., towards the big toe)." ; oboInOwl:hasBroadSynonym "Curvature of 2nd toe" ; oboInOwl:hasDbXref "UMLS:C4021620", "UMLS:C4280473" ; oboInOwl:hasExactSynonym "Clinodactyly of second toes" ; oboInOwl:id "HP:0005824" ; a owl:Class ; rdfs:label "Clinodactyly of the 2nd toe" ; rdfs:subClassOf obo:HP_0001863, obo:HP_0010326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005825 oboInOwl:hasDbXref "UMLS:C4025128" ; oboInOwl:id "HP:0005825" ; a owl:Class ; rdfs:label "Mixed sclerosis of humeral metaphyses" ; rdfs:subClassOf obo:HP_0003918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0005828 oboInOwl:hasDbXref "UMLS:C3805920" ; oboInOwl:id "HP:0005828" ; a owl:Class ; rdfs:label "Transient pulmonary infiltrates" ; rdfs:subClassOf obo:HP_0002113 . obo:HP_0005829 oboInOwl:hasDbXref "UMLS:C3149879" ; oboInOwl:id "HP:0005829" ; a owl:Class ; rdfs:label "Maldevelopment of radioulnar joint" ; rdfs:subClassOf obo:HP_0003059 . obo:HP_0005830 obo:IAO_0000115 "One or more bent (flexed) toe joints that cannot be straightened actively or passively." ; oboInOwl:hasAlternativeId "HP:0001860", "HP:0008128", "HP:0008367", "HP:0200027" ; oboInOwl:hasDbXref "UMLS:C1406835" ; oboInOwl:hasExactSynonym "Contractures involving the toes", "Contractures of the toes", "Toe contractures" ; oboInOwl:id "HP:0005830" ; a owl:Class ; rdfs:label "Flexion contracture of toe" ; rdfs:subClassOf obo:HP_0008366, obo:HP_0030044, obo:HP_0034675 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005831 oboInOwl:hasDbXref "MSH:C566196", "UMLS:C1862112" ; oboInOwl:id "HP:0005831" ; a owl:Class ; rdfs:label "Type B brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0005832 obo:IAO_0000115 "A type of dysharmonic skeletal maturation in which there is a delay in skeletal maturation whose degree differs markedly in different bones." ; oboInOwl:hasAlternativeId "HP:0005840" ; oboInOwl:hasDbXref "UMLS:C1859444" ; oboInOwl:id "HP:0005832" ; a owl:Class ; rdfs:label "Dysharmonic delayed bone age" ; rdfs:subClassOf obo:HP_0002750, obo:HP_0200000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000692 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005833 oboInOwl:consider "HP:0001386" ; oboInOwl:id "HP:0005833" ; a owl:Class ; rdfs:label "obsolete Joint swelling onset late infancy" ; owl:deprecated true . obo:HP_0005834 obo:IAO_0100001 "HP:0009658" ; oboInOwl:id "HP:0005834" ; a owl:Class ; rdfs:label "obsolete Thumbs hypo/aplastic" ; owl:deprecated true . obo:HP_0005837 obo:IAO_0100001 "HP:0001373" ; oboInOwl:id "HP:0005837" ; a owl:Class ; rdfs:label "obsolete Joint dislocations in young adult" ; owl:deprecated true . obo:HP_0005841 oboInOwl:hasDbXref "UMLS:C1859135" ; oboInOwl:id "HP:0005841" ; a owl:Class ; rdfs:label "Calcific stippling of infantile cartilaginous skeleton" ; rdfs:subClassOf obo:HP_0003336 . obo:HP_0005844 obo:IAO_0000115 "An abnormally round shape of the middle phalanx of the finger." ; oboInOwl:hasDbXref "UMLS:C4025126" ; oboInOwl:hasExactSynonym "Rounded middle bone of finger" ; oboInOwl:id "HP:0005844" ; a owl:Class ; rdfs:label "Rounded middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005848 obo:IAO_0100001 "HP:0009611" ; a owl:Class ; rdfs:label "obsolete Bifid thumb distal phalanx" ; owl:deprecated true . obo:HP_0005849 obo:IAO_0000115 "Generalized deposition of calcium salts within the brain." ; oboInOwl:hasDbXref "UMLS:C4025125" ; oboInOwl:id "HP:0005849" ; a owl:Class ; rdfs:label "Diffuse cerebral calcification" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0005850 oboInOwl:hasDbXref "MSH:D005413", "SNOMEDCT_US:205083002", "SNOMEDCT_US:31668003", "UMLS:C0152237" ; oboInOwl:id "HP:0005850" ; a owl:Class ; rdfs:label "Congenital talipes calcaneovalgus" ; rdfs:subClassOf obo:HP_0001884 . obo:HP_0005852 oboInOwl:hasDbXref "UMLS:C4025124" ; oboInOwl:id "HP:0005852" ; a owl:Class ; rdfs:label "Limited elbow extension and supination" ; rdfs:subClassOf obo:HP_0001377 . obo:HP_0005853 oboInOwl:hasDbXref "UMLS:C4025123" ; oboInOwl:id "HP:0005853" ; a owl:Class ; rdfs:label "Congenital foot contraction deformities" ; rdfs:subClassOf obo:HP_0002803 . obo:HP_0005855 obo:IAO_0000115 "The presence of bone fractures in the prenatal period that are diagnosed at birth or before." ; oboInOwl:hasAlternativeId "HP:0002811", "HP:0005761" ; oboInOwl:hasDbXref "UMLS:C1853171" ; oboInOwl:hasExactSynonym "Congenital bone fractures", "Multiple fractures present at birth", "Multiple fractures, present at birth", "Numerous multiple fractures present at birth", "Numerous multiple fractures that are present at birth" ; oboInOwl:id "HP:0005855" ; a owl:Class ; rdfs:label "Multiple prenatal fractures" ; rdfs:subClassOf obo:HP_0002659 . obo:HP_0005856 obo:IAO_0000115 "A dislocation of the head of the radius from its socket in the elbow joint in an ulnar direction." ; oboInOwl:hasDbXref "UMLS:C4021619" ; oboInOwl:hasExactSynonym "Ulnar dislocation of radial heads" ; oboInOwl:id "HP:0005856" ; a owl:Class ; rdfs:label "Ulnar radial head dislocation" ; rdfs:subClassOf obo:HP_0003083 . obo:HP_0005857 oboInOwl:hasDbXref "SNOMEDCT_US:32232003", "UMLS:C0266501" ; oboInOwl:id "HP:0005857" ; a owl:Class ; rdfs:label "Cervical spina bifida" ; rdfs:subClassOf obo:HP_0002414 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017670 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005863 obo:IAO_0000115 "In type E brachydactyly, shortening of the fingers is mainly in the metacarpals and metatarsals." ; oboInOwl:hasAlternativeId "HP:0006115" ; oboInOwl:hasDbXref "MSH:C566194", "UMLS:C1862102" ; oboInOwl:id "HP:0005863" ; a owl:Class ; rdfs:label "Type E brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0005864 obo:IAO_0000115 "A pathologic entity characterized by a developmental defect in a long bone leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or \"false joint\")." ; oboInOwl:hasDbXref "MSH:D011542", "SNOMEDCT_US:31511007", "SNOMEDCT_US:410818009", "UMLS:C0033785" ; oboInOwl:hasExactSynonym "Pseudoarthroses" ; oboInOwl:id "HP:0005864" ; a owl:Class ; rdfs:label "Pseudoarthrosis" ; rdfs:subClassOf obo:HP_0011314 . obo:HP_0005866 obo:IAO_0000115 "A form of triphalangeal thumb that can be placed opposite the fingers of the same hand." ; oboInOwl:hasDbXref "UMLS:C4025122" ; oboInOwl:id "HP:0005866" ; a owl:Class ; rdfs:label "Opposable triphalangeal thumb" ; rdfs:subClassOf obo:HP_0001199 . obo:HP_0005867 oboInOwl:hasDbXref "UMLS:C1859768" ; oboInOwl:hasExactSynonym "Fused 4th-5th long bones of hand", "Fused 4th-5th metacarpals", "Fused fourth and fifth metacarpals", "Ring finger and little finger metacarpal synostosis", "Synostosis of the fourth and fifth metacarpal bones" ; oboInOwl:id "HP:0005867" ; a owl:Class ; rdfs:label "4-5 metacarpal synostosis" ; rdfs:subClassOf obo:HP_0009707, obo:HP_0009708 . obo:HP_0005868 obo:IAO_0000115 "An enchondroma is a benign growth of cartilage that develops within the medullary cavity of bone. Enchondromatosis refers to the presence of multiple enchondromas, and this term refers to the presence of multiple enchondromas within the medulla of metaphyseal bone. Radiographically an enchondroma presents a an oval, linear, or pyramidal osteolytic (radiolucent) lesion with well defined margins." ; oboInOwl:hasDbXref "UMLS:C4025121" ; oboInOwl:id "HP:0005868" ; a owl:Class ; rdfs:label "Metaphyseal enchondromatosis" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0005871 obo:IAO_0000115 "An abnormality of skeletal development characterized by a disturbance of the metaphysis and its histological structure with relatively normal epiphyses and vertebrae." ; oboInOwl:hasAlternativeId "HP:0006377" ; oboInOwl:hasDbXref "SNOMEDCT_US:28681006", "UMLS:C0265290" ; oboInOwl:id "HP:0005871" ; a owl:Class ; rdfs:comment "The term metaphyseal chondrodysplasia is usually used to describe a disease but is often also used to describe the corresponding phenotypic appearance. This use is retained in the HPO for convenience, but if possible a precise phenotypic description is preferred." ; rdfs:label "Metaphyseal chondrodysplasia" ; rdfs:subClassOf obo:HP_0100255 . obo:HP_0005872 obo:IAO_0000115 "Disproportionately short middle and distal phalanges compared to the hand/foot." ; oboInOwl:hasAlternativeId "HP:0005777", "HP:0006093" ; oboInOwl:hasDbXref "UMLS:C1847408" ; oboInOwl:hasExactSynonym "Progressive brachydactyly of middle and distal phalanges", "Short middle and distal phalanges of digits ii through v" ; oboInOwl:id "HP:0005872" ; a owl:Class ; rdfs:label "Brachytelomesophalangy" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0005873 obo:IAO_0000115 "Combined syndactyly and polydactyly of the great toe." ; oboInOwl:hasDbXref "UMLS:C4021618" ; oboInOwl:hasExactSynonym "Polysyndactyly of big toe", "Polysyndactyly of great toe" ; oboInOwl:id "HP:0005873" ; a owl:Class ; rdfs:label "Polysyndactyly of hallux" ; rdfs:subClassOf obo:HP_0001841 . obo:HP_0005875 oboInOwl:hasDbXref "UMLS:C4025120" ; oboInOwl:id "HP:0005875" ; a owl:Class ; rdfs:label "Increased dermatoglyphic whorls" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0005876 obo:IAO_0000115 "Progressively worsening joint contractures." ; oboInOwl:hasDbXref "UMLS:C3279322" ; oboInOwl:hasExactSynonym "Joint contractures, progressive" ; oboInOwl:id "HP:0005876" ; a owl:Class ; rdfs:label "Progressive flexion contractures" ; rdfs:subClassOf obo:HP_0001371 . obo:HP_0005877 oboInOwl:hasDbXref "UMLS:C4025119" ; oboInOwl:id "HP:0005877" ; a owl:Class ; rdfs:label "Multiple small vertebral fractures" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0005878 oboInOwl:hasDbXref "UMLS:C4025118" ; oboInOwl:id "HP:0005878" ; a owl:Class ; rdfs:label "Enlarged sagittal diameter of the cervical canal" ; rdfs:subClassOf obo:HP_0003319 . obo:HP_0005879 obo:IAO_0000115 "Multiple bent (flexed) finger joints that cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C1393871" ; oboInOwl:hasExactSynonym "Congenital finger contractures" ; oboInOwl:id "HP:0005879" ; a owl:Class ; rdfs:label "Congenital finger flexion contractures" ; rdfs:subClassOf obo:HP_0002803, obo:HP_0100490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002803 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005880 obo:IAO_0000115 "Fusion of a metacarpal bone with the proximal phalanx of the finger distal to it across the corresponding metacarpophalangeal joint." ; oboInOwl:hasAlternativeId "HP:0100325" ; oboInOwl:hasDbXref "UMLS:C4025117" ; oboInOwl:hasExactSynonym "Fused long bone of hand with innermost finger bone" ; oboInOwl:id "HP:0005880" ; a owl:Class ; rdfs:label "Metacarpophalangeal synostosis" ; rdfs:subClassOf obo:HP_0009700, obo:HP_0009701, obo:HP_0011911 . obo:HP_0005881 oboInOwl:hasDbXref "SNOMEDCT_US:240220009", "UMLS:C0410648" ; oboInOwl:id "HP:0005881" ; a owl:Class ; rdfs:label "Spinal instability" ; rdfs:subClassOf obo:HP_0000925 . obo:HP_0005882 oboInOwl:hasDbXref "UMLS:C4025116" ; oboInOwl:id "HP:0005882" ; a owl:Class ; rdfs:label "Dermatoglyphic variants" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0005885 obo:IAO_0000115 "A lack of bone mineralization of one or more body of cervical vertebra." ; oboInOwl:hasDbXref "UMLS:C4025115" ; oboInOwl:id "HP:0005885" ; a owl:Class ; rdfs:label "Absent ossification of cervical vertebral bodies" ; rdfs:subClassOf obo:HP_0004599 ; owl:equivalentClass _:genid56189 . obo:HP_0005886 obo:IAO_0000115 "Absence of a digit or of one or more phalanges of a finger." ; oboInOwl:hasDbXref "UMLS:C4025114" ; oboInOwl:id "HP:0005886" ; a owl:Class ; rdfs:label "Aphalangy of the hands" ; rdfs:subClassOf obo:HP_0009767 . obo:HP_0005890 obo:IAO_0000115 "Bony overgrowth of the internal (endosteal) surface of the calvaria and the base of skull." ; oboInOwl:hasBroadSynonym "Enlargement of the inner surface of the skull bones", "Hypertrophy of the internal surface of the cranial bones", "Increased ossification of the internal surface of the cranial bones", "Overgrowth of the inside of the skull", "Thick inner surface of the skull bones", "Thick internal surface of the cranial bones" ; oboInOwl:hasDbXref "MSH:C564168", "UMLS:C1840404", "UMLS:C4280468", "UMLS:C4280469", "UMLS:C4280470", "UMLS:C4280471", "UMLS:C4280472" ; oboInOwl:hasExactSynonym "Excessive growth of inner surface of the skull bones", "Hyperostosis of the internal surface of the cranial bone", "Hyperostosis of the internal surface of the cranial bones", "Overgrowth of the inner surface of the skull bones" ; oboInOwl:id "HP:0005890" ; a owl:Class ; rdfs:label "Hyperostosis cranialis interna" ; rdfs:subClassOf obo:HP_0004437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017692 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005891 obo:IAO_0000115 "Progressive bending or abnormal curvature of the forearm skeleton." ; oboInOwl:hasDbXref "UMLS:C3152020" ; oboInOwl:hasExactSynonym "Progressive forearm curvature" ; oboInOwl:id "HP:0005891" ; a owl:Class ; rdfs:label "Progressive forearm bowing" ; rdfs:subClassOf obo:HP_0003956, obo:HP_0006383 . obo:HP_0005892 oboInOwl:hasDbXref "UMLS:C4025113" ; oboInOwl:hasExactSynonym "Fusion of innermost shinbone and calf bone" ; oboInOwl:id "HP:0005892" ; a owl:Class ; rdfs:label "Proximal tibial and fibular fusion" ; rdfs:subClassOf obo:HP_0005928, obo:HP_0005929 . obo:HP_0005894 obo:IAO_0000115 "Duplication of the metacarpal I bones." ; oboInOwl:hasDbXref "UMLS:C4025112" ; oboInOwl:hasExactSynonym "Double 1st long bones of hand" ; oboInOwl:id "HP:0005894" ; a owl:Class ; rdfs:label "Double first metacarpals" ; rdfs:subClassOf obo:HP_0005917 . obo:HP_0005895 oboInOwl:hasDbXref "UMLS:C4025111" ; oboInOwl:id "HP:0005895" ; a owl:Class ; rdfs:label "Radial deviation of thumb terminal phalanx" ; rdfs:subClassOf obo:HP_0009617 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005897 obo:IAO_0000115 "Severe degree of osteoporosis." ; oboInOwl:hasAlternativeId "HP:0005838" ; oboInOwl:hasDbXref "UMLS:C1859443" ; oboInOwl:hasExactSynonym "Severe generalised osteoporosis", "Severe, generalised osteoporosis", "Severe, generalized osteoporosis" ; oboInOwl:id "HP:0005897" ; a owl:Class ; rdfs:label "Severe generalized osteoporosis" ; rdfs:subClassOf obo:HP_0040160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0040160 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005899 obo:IAO_0100001 "HP:0100255" ; oboInOwl:id "HP:0005899" ; a owl:Class ; rdfs:label "obsolete Metaphyseal dysostosis" ; owl:deprecated true . obo:HP_0005900 obo:IAO_0000115 "Presence of an angular or V -shaped indentation on the ulnar side of the fifth metacarpal bone (i.e., on the sides towards the fifth finger)." ; oboInOwl:hasDbXref "UMLS:C3276324" ; oboInOwl:hasExactSynonym "Fifth metacarpal notched on ulnar side" ; oboInOwl:id "HP:0005900" ; a owl:Class ; rdfs:label "Fifth metacarpal with ulnar notch" ; rdfs:subClassOf obo:HP_0010013 . obo:HP_0005901 obo:IAO_0100001 "HP:0002754" ; oboInOwl:id "HP:0005901" ; a owl:Class ; rdfs:label "obsolete Chronic recurrent multifocal osteomyelitis" ; owl:deprecated true . obo:HP_0005905 obo:IAO_0000115 "The presence of an abnormal curvature of the cervical vertebral column." ; oboInOwl:hasDbXref "UMLS:C3151523" ; oboInOwl:hasExactSynonym "Abnormal neck curve" ; oboInOwl:id "HP:0005905" ; a owl:Class ; rdfs:label "Abnormal cervical curvature" ; rdfs:subClassOf obo:HP_0010674, obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001591 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005906 obo:IAO_0000115 "An abnormally reduced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms." ; oboInOwl:hasDbXref "UMLS:C4021617" ; oboInOwl:hasExactSynonym "Mastoid processes poorly pneumatized" ; oboInOwl:id "HP:0005906" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Delayed pneumatization of the mastoid process" ; rdfs:subClassOf obo:HP_0000264 . obo:HP_0005910 obo:IAO_0000115 "Rhomboid or triangular shaped 5th (little) finger middle phalanx." ; oboInOwl:hasDbXref "UMLS:C4021616" ; oboInOwl:hasExactSynonym "Rhomboid or triangular shaped fifth finger middle phalanx" ; oboInOwl:id "HP:0005910" ; a owl:Class ; rdfs:label "Rhomboid or triangular shaped 5th finger middle phalanx" ; rdfs:subClassOf obo:HP_0009182 . obo:HP_0005912 obo:IAO_0000115 "Atresia of the biliary tree." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:07:00Z" ; oboInOwl:hasDbXref "MSH:D001656", "SNOMEDCT_US:77480004", "SNOMEDCT_US:82821008", "UMLS:C0005411" ; oboInOwl:hasExactSynonym "Biliary duct atresia" ; oboInOwl:id "HP:0005912" ; a owl:Class ; rdfs:label "Biliary atresia" ; rdfs:subClassOf obo:HP_0012440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005913 dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4025110" ; oboInOwl:hasExactSynonym "Abnormality of end part of long bone of hand", "Abnormality of metacarpal epiphyses" ; oboInOwl:id "HP:0005913" ; a owl:Class ; rdfs:label "Abnormal metacarpal epiphysis morphology" ; rdfs:subClassOf obo:HP_0005916, obo:HP_0005924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005914 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:14:00Z" ; oboInOwl:hasAlternativeId "HP:0006007" ; oboInOwl:hasDbXref "UMLS:C1836192" ; oboInOwl:hasExactSynonym "Absent or hypoplastic metacarpals", "Absent/small long bones of hand", "Absent/underdeveloped long bones of hand", "Aplastic/hypoplastic metacarpals", "Hypoplastic metacarpals", "Hypoplastic/absent metacarpal bones", "Hypoplastic/absent metacarpals", "Metacarpal aplasia/hypoplasia" ; oboInOwl:id "HP:0005914" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the metacarpal bones" ; rdfs:subClassOf obo:HP_0005916, obo:HP_0005927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005916 obo:IAO_0000115 "Any abnormal shape or structure of the metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:17:00Z" ; oboInOwl:hasAlternativeId "HP:0001163", "HP:0010556" ; oboInOwl:hasDbXref "UMLS:C4021615" ; oboInOwl:hasExactSynonym "Abnormal shape of long bones of hand", "Abnormal shape of metacarpal bones" ; oboInOwl:id "HP:0005916" ; a owl:Class ; rdfs:label "Abnormal metacarpal morphology" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005917 obo:IAO_0000115 "The presence of more than the normal number of metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:18:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:91846008", "UMLS:C0545617" ; oboInOwl:hasExactSynonym "Extra long bones of hand" ; oboInOwl:id "HP:0005917" ; a owl:Class ; rdfs:label "Supernumerary metacarpal bones" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005918 obo:IAO_0000115 "Abnormalities affecting the phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:19:00Z" ; oboInOwl:hasAlternativeId "HP:0005786", "HP:0006259" ; oboInOwl:hasDbXref "UMLS:C4021614" ; oboInOwl:hasExactSynonym "Abnormal form of phalanges of the hand", "Abnormality of phalanx of finger", "Abnormality of the finger bones", "Abnormality of the phalanges", "Abnormality of the phalanges of the hand" ; oboInOwl:id "HP:0005918" ; a owl:Class ; rdfs:comment "This category is a supercategory for abnormalties affect phalanges of the hand." ; rdfs:label "Abnormal finger phalanx morphology" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005920 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the phalanges of the hand. Note that this includes the epiphysis of the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:21:00Z" ; oboInOwl:hasAlternativeId "HP:0009151" ; oboInOwl:hasDbXref "UMLS:C4021613" ; oboInOwl:id "HP:0005920" ; a owl:Class ; rdfs:label "Abnormal epiphysis morphology of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918, obo:HP_0005924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005921 obo:IAO_0100001 "HP:0010660" ; oboInOwl:id "HP:0005921" ; a owl:Class ; rdfs:label "obsolete Abnormal ossification of hand bones" ; owl:deprecated true . obo:HP_0005922 obo:IAO_0000115 "Any structural anomaly of the hand." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:25:00Z" ; oboInOwl:hasAlternativeId "HP:0003098" ; oboInOwl:hasDbXref "UMLS:C4025109" ; oboInOwl:hasExactSynonym "Abnormal shape of hand" ; oboInOwl:id "HP:0005922" ; a owl:Class ; rdfs:comment "This is a category to be used for general descriptions of hand dysmorphology. In time, it should be replaced by more accurate descriptions." ; rdfs:label "Abnormal hand morphology" ; rdfs:subClassOf obo:HP_0001155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005923 dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:27:00Z" ; oboInOwl:hasDbXref "UMLS:C4025108" ; oboInOwl:hasExactSynonym "Abnormalities of the metaphyses of the hand", "Abnormality of the wide portion of the hand bone" ; oboInOwl:id "HP:0005923" ; a owl:Class ; rdfs:label "Abnormal hand metaphysis morphology" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0009809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005924 obo:IAO_0000115 "Any abnormality of the epiphyses of the phalanges or metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:28:00Z" ; oboInOwl:hasDbXref "UMLS:C4025107" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the hand bone", "Abnormality of the end part of the hand bones", "Abnormality of the epiphyses of the fingers", "Abnormality of the epiphyses of the hand", "Abnormality of the epiphyses of the phalanges of the hand" ; oboInOwl:id "HP:0005924" ; a owl:Class ; rdfs:label "Abnormal hand epiphysis morphology" ; rdfs:subClassOf obo:HP_0003839, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005925 dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:28:00Z" ; oboInOwl:hasDbXref "UMLS:C4025106" ; oboInOwl:hasExactSynonym "Abnormalities of shaft of long bone of the hand", "Abnormalities of the diaphyses of the hand" ; oboInOwl:id "HP:0005925" ; a owl:Class ; rdfs:label "Abnormal hand diaphysis morphology" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0009808 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005926 obo:IAO_0000115 "An anomaly of the outer shell (cortex) of a hand bone." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4025105" ; oboInOwl:hasExactSynonym "Abnormality of hand cortical bone", "Abnormality of the cortex of hand bones" ; oboInOwl:id "HP:0005926" ; a owl:Class ; rdfs:label "Abnormal hand cortical bone morphology" ; rdfs:subClassOf obo:HP_0003103, obo:HP_0005922 . obo:HP_0005927 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of the bones of the hand." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4021612" ; oboInOwl:hasExactSynonym "Absent/small hand bones", "Absent/underdeveloped hand bones", "Hypoplasia/absence of hand bones" ; oboInOwl:id "HP:0005927" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving bones of the hand" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0006496 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005928 dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:34:00Z" ; oboInOwl:hasDbXref "UMLS:C4025104" ; oboInOwl:hasExactSynonym "Bone fusion involving the calf bones" ; oboInOwl:id "HP:0005928" ; a owl:Class ; rdfs:label "Synostosis involving the fibula" ; rdfs:subClassOf obo:HP_0002991, obo:HP_0009138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005929 dcterms:creator ; oboInOwl:creation_date "2008-03-27T02:34:00Z" ; oboInOwl:hasDbXref "UMLS:C4025103" ; oboInOwl:hasExactSynonym "Bone fusion involving the shinbone" ; oboInOwl:id "HP:0005929" ; a owl:Class ; rdfs:label "Synostosis involving the tibia" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0009138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005930 obo:IAO_0000115 "An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T03:00:00Z" ; oboInOwl:hasAlternativeId "HP:0000936" ; oboInOwl:hasDbXref "UMLS:C4021611" ; oboInOwl:hasExactSynonym "Abnormal shape of end part of bone", "Abnormality of epiphysis morphology", "Abnormality of the epiphyses", "Anomaly of the epiphyses", "Epiphyseal abnormality" ; oboInOwl:id "HP:0005930" ; a owl:Class ; rdfs:label "Abnormal epiphysis morphology" ; rdfs:subClassOf obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005932 obo:IAO_0000115 "An abnormality of corticomedullary differentiation (CMD) on diagnostic imaging such as magnetic resonance imaging, computer tomography, or sonography. CMD is a difference in the visualization of cortex and medulla." ; dcterms:creator ; oboInOwl:creation_date "2008-03-27T03:21:00Z" ; oboInOwl:hasDbXref "UMLS:C4025102" ; oboInOwl:id "HP:0005932" ; a owl:Class ; rdfs:comment "On T1-weighted magnetic resonance imaging, the signal intensity of the normal renal cortex is typically higher than medulla, resulting in easily visualized corticomedullary differentiation (CMD). Loss of CMD can be seen in disorders such as glomerulonephritis, acute tubular necrosis, end-stage chronic renal failure, obstructive hydronephrosis, and acute allograft rejection. Progressive corticomedullary differentiation (CMD) can be visualized as an echogenic cortex and a hypoechoic medulla. This CMD should be visible during the midtrimester sonographic evaluation." ; rdfs:label "Abnormal renal corticomedullary differentiation" ; rdfs:subClassOf obo:HP_0011035, obo:HP_0100957 . obo:HP_0005934 oboInOwl:hasDbXref "UMLS:C4025101" ; oboInOwl:id "HP:0005934" ; a owl:Class ; rdfs:label "Imperfect vocal cord adduction" ; rdfs:subClassOf obo:HP_0031801 . obo:HP_0005938 obo:IAO_0000115 "Abnormal arrangement of the structures of the motile cilium." ; oboInOwl:hasDbXref "UMLS:C4025100" ; oboInOwl:id "HP:0005938" ; a owl:Class ; rdfs:label "Abnormal respiratory motile cilium morphology" ; rdfs:subClassOf obo:HP_0012253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0031514 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005939 oboInOwl:hasDbXref "UMLS:C4025099" ; oboInOwl:id "HP:0005939" ; a owl:Class ; rdfs:label "Multiple bilateral pneumothoraces" ; rdfs:subClassOf obo:HP_0002107 . obo:HP_0005941 oboInOwl:hasDbXref "UMLS:C4025098" ; oboInOwl:id "HP:0005941" ; a owl:Class ; rdfs:label "Intermittent hyperpnea at rest" ; rdfs:subClassOf obo:HP_0004879 . obo:HP_0005942 obo:IAO_0000115 "Diffuse filling of the distal airsspaces of the lungs, the alveoli, with macrophages. Desquamative interstitial pneumonitis (DIP) is characterized additionally by thickend alveolar septa and by a sparse inflammatory infiltrate that often includes plasma cells and occasional eosinophils. The alveoli are lined by plump cuboidal pneumocytes. Lymphoid aggregates may be present." ; oboInOwl:hasDbXref "MSH:C562470", "SNOMEDCT_US:8549006", "UMLS:C0238378" ; oboInOwl:hasExactSynonym "Filling of the alveoli with alveolar macrophages" ; oboInOwl:hasRelatedSynonym "Filling of the alveoli with desquamated epithelial cells", "Intra-alveolar accumulation of macrophages" ; oboInOwl:id "HP:0005942" ; a owl:Class ; rdfs:comment "The name originated from the belief that the dominant histologic feature was desquamation of epithelial cells. However, this is now recognized to be intra-alveolar macrophage accumulation rather than desquamation of epithelial cells as originally thought by Liebow and Carrington. In adults the condition is almost invariable associated with cigarette smoke. However, rare cases occur in nonsmokers, some of whom have had exposure to environmental inhalation exposures including passive exposure to cigarette smoke. In children genetically caused surfactant dysfunction syndromes may have the histological pattern of DIP." ; rdfs:label "Desquamative interstitial pneumonitis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0005943 oboInOwl:hasDbXref "SNOMEDCT_US:87317003", "UMLS:C0162297" ; oboInOwl:hasExactSynonym "Breathing cessation" ; oboInOwl:id "HP:0005943" ; a owl:Class ; rdfs:label "Respiratory arrest" ; rdfs:subClassOf obo:HP_0002093 . obo:HP_0005944 obo:IAO_0000115 "Bilateral lack of development of the lungs." ; oboInOwl:hasAlternativeId "HP:0006550" ; oboInOwl:hasDbXref "Fyler:4206", "UMLS:C4021610" ; oboInOwl:hasExactSynonym "Absent lungs", "Bilateral pulmonary agenesis" ; oboInOwl:id "HP:0005944" ; a owl:Class ; rdfs:label "Bilateral lung agenesis" ; rdfs:subClassOf obo:HP_0006703 . obo:HP_0005945 obo:IAO_0000115 "Blockage of the upper airway at the level of the larynx often accompanied by respiratory distress." ; oboInOwl:hasDbXref "SNOMEDCT_US:61169001", "UMLS:C0264306" ; oboInOwl:id "HP:0005945" ; a owl:Class ; rdfs:label "Laryngeal obstruction" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005946 oboInOwl:hasDbXref "UMLS:C4025097" ; oboInOwl:id "HP:0005946" ; a owl:Class ; rdfs:label "Ventilator dependence with inability to wean" ; rdfs:subClassOf obo:HP_0004887 . obo:HP_0005947 obo:IAO_0000115 "Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration." ; oboInOwl:hasDbXref "UMLS:C3806286" ; oboInOwl:hasExactSynonym "Decreased sensitivity to hypoxaemia", "Decreased sensitivity to hypoxemia" ; oboInOwl:id "HP:0005947" ; a owl:Class ; rdfs:comment "Note that hypoxia is defined as lack of oxygen in tissues. Hypoxia is usually preceded by hypoxemia (decreased concentration of oxygen in blood)." ; rdfs:label "Decreased sensitivity to hypoxemia" ; rdfs:subClassOf obo:HP_0005957 . obo:HP_0005948 obo:IAO_0000115 "The presence of multiple lung cysts." ; oboInOwl:hasDbXref "MSH:C563237", "UMLS:C1384901" ; oboInOwl:hasExactSynonym "Cystic lung disease", "Multiple lung cysts" ; oboInOwl:id "HP:0005948" ; a owl:Class ; rdfs:comment "Emphysematous changes sometimes can be mistaken for multifocal lung cysts. In contrast to true cysts, the cystlike lucencies caused by the destruction of lung parenchyma in emphy-sema do not have walls. Nevertheless, emphysema can be accompanied by multiple cysts, such as bullae, or in association with LCH." ; rdfs:label "Multiple pulmonary cysts" ; rdfs:subClassOf obo:HP_0032445 . obo:HP_0005949 obo:IAO_0000115 "Recurrent episodes of apnea occurring during infancy." ; oboInOwl:hasDbXref "UMLS:C3807980" ; oboInOwl:id "HP:0005949" ; a owl:Class ; rdfs:label "Apneic episodes in infancy" ; rdfs:subClassOf obo:HP_0002104 . obo:HP_0005950 obo:IAO_0000115 "A membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords." ; oboInOwl:hasDbXref "SNOMEDCT_US:297159008", "UMLS:C0281890" ; oboInOwl:hasExactSynonym "Laryngeal webs", "Partial laryngeal atresia" ; oboInOwl:id "HP:0005950" ; a owl:Class ; rdfs:comment "Manifestations may appear at any age (hoarse or weak voice and frequent upper respiratory infections) but onset usually occurs during infancy (respiratory distress, stridor and an unusual cry)." ; rdfs:label "Laryngeal web" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0005951 oboInOwl:hasDbXref "UMLS:C4025096" ; oboInOwl:id "HP:0005951" ; a owl:Class ; rdfs:label "Progressive inspiratory stridor" ; rdfs:subClassOf obo:HP_0005348 . obo:HP_0005952 obo:IAO_0100001 "HP:0002795" ; oboInOwl:id "HP:0005952" ; a owl:Class ; rdfs:label "obsolete Decreased pulmonary function" ; owl:deprecated true . obo:HP_0005954 oboInOwl:hasDbXref "SNOMEDCT_US:233949008", "UMLS:C0340548" ; oboInOwl:hasExactSynonym "Pulmonary hemangiomas" ; oboInOwl:id "HP:0005954" ; a owl:Class ; rdfs:label "Pulmonary capillary hemangiomatosis" ; rdfs:subClassOf obo:HP_0004930, obo:HP_0005306, obo:HP_0007461 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0007461 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016405 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005956 obo:IAO_0000115 "Abnormal shortening of the larynx in the anteroposterior (front to back) axis." ; oboInOwl:hasDbXref "UMLS:C3805994" ; oboInOwl:id "HP:0005956" ; a owl:Class ; rdfs:label "Anteroposteriorly shortened larynx" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0005957 oboInOwl:hasDbXref "UMLS:C3808046" ; oboInOwl:id "HP:0005957" ; a owl:Class ; rdfs:label "Breathing dysregulation" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0005959 obo:IAO_0000115 "An impairment of gluconeogenesis." ; oboInOwl:hasDbXref "UMLS:C3279336" ; oboInOwl:hasExactSynonym "Gluconeogenesis impaired" ; oboInOwl:id "HP:0005959" ; a owl:Class ; rdfs:label "Impaired gluconeogenesis" ; rdfs:subClassOf obo:HP_0011014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005961 obo:IAO_0000115 "A decreased concentration of arginine in the blood." ; oboInOwl:hasDbXref "UMLS:C1859735", "UMLS:C4025095" ; oboInOwl:hasExactSynonym "Low blood arginine levels" ; oboInOwl:hasRelatedSynonym "Arginine deficiency" ; oboInOwl:id "HP:0005961" ; a owl:Class ; rdfs:label "Hypoargininemia" ; rdfs:subClassOf obo:HP_0010909 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005964 obo:IAO_0000115 "Episodes of reduced body termperature." ; oboInOwl:hasAlternativeId "HP:0005970" ; oboInOwl:hasDbXref "UMLS:C1837639" ; oboInOwl:hasExactSynonym "Intermittent abnormally low body temperature", "Intermittent hypothermia" ; oboInOwl:id "HP:0005964" ; a owl:Class ; rdfs:label "Intermittent hypothermia" ; rdfs:subClassOf obo:HP_0002045 . obo:HP_0005967 oboInOwl:hasDbXref "UMLS:C1840372" ; oboInOwl:id "HP:0005967" ; a owl:Class ; rdfs:label "Mixed respiratory and metabolic acidosis" ; rdfs:subClassOf obo:HP_0001942 . obo:HP_0005968 obo:IAO_0000115 "Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature." ; oboInOwl:hasDbXref "UMLS:C1820737", "UMLS:C3279038" ; oboInOwl:hasExactSynonym "Temperature instability" ; oboInOwl:hasRelatedSynonym "Body temperature instability" ; oboInOwl:id "HP:0005968" ; a owl:Class ; rdfs:label "Temperature instability" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0005972 obo:IAO_0000115 "Acidosis because of respiratory retention of carbon dioxide." ; oboInOwl:hasDbXref "MSH:D000142", "SNOMEDCT_US:12326000", "UMLS:C0001127" ; oboInOwl:id "HP:0005972" ; a owl:Class ; rdfs:label "Respiratory acidosis" ; rdfs:subClassOf obo:HP_0001941 . obo:HP_0005973 obo:IAO_0000115 "Reduced intestinal absorption of fructose. Breath testing after ingestion of fructose has been widely adopted as a standard method of identifying fructose malabsorption and intolerance. A dose of 25 g of fructose dissolved in a 10% solution is generally accepted as the appropriate dose of fructose for clinical use of H2 and CH4 breath testing. High levels of hydrogen in exhaled breath subsequent hours indicate fructose intolerance. Presence of malabsorption and reproduction of symptoms during a breath test provides the best objective evidence and symptom correlation for fructose intolerance." ; oboInOwl:hasDbXref "MSH:D005633", "SNOMEDCT_US:20052008", "UMLS:C0016751" ; oboInOwl:hasExactSynonym "Fructose malabsorption" ; oboInOwl:id "HP:0005973" ; a owl:Class ; rdfs:label "Fructose intolerance" ; rdfs:subClassOf obo:HP_0011033 . obo:HP_0005974 obo:IAO_0000115 "Intermittent episodes of ketoacidosis." ; oboInOwl:hasAlternativeId "HP:0005981", "HP:0005983" ; oboInOwl:hasDbXref "UMLS:C1859860" ; oboInOwl:hasExactSynonym "Ketoacidosis, episodic" ; oboInOwl:id "HP:0005974" ; a owl:Class ; rdfs:label "Episodic ketoacidosis" ; rdfs:subClassOf obo:HP_0001993 . obo:HP_0005976 oboInOwl:hasDbXref "UMLS:C1865880" ; oboInOwl:id "HP:0005976" ; a owl:Class ; rdfs:label "Hyperkalemic metabolic acidosis" ; rdfs:subClassOf obo:HP_0001942 . obo:HP_0005977 oboInOwl:hasDbXref "UMLS:C0740895" ; oboInOwl:id "HP:0005977" ; a owl:Class ; rdfs:label "Hypochloremic metabolic alkalosis" ; rdfs:subClassOf obo:HP_0001948 . obo:HP_0005978 obo:IAO_0000115 "A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia." ; oboInOwl:hasAlternativeId "HP:0005965", "HP:0100652" ; oboInOwl:hasDbXref "MSH:D003924", "SNOMEDCT_US:44054006", "UMLS:C0011860" ; oboInOwl:hasExactSynonym "Diabetes mellitus Type II", "Diabetes mellitus, noninsulin-dependent", "NIDDM", "NIDDM diabetes mellitus", "Non-insulin dependent diabetes", "Noninsulin dependent diabetes mellitus", "Noninsulin-dependent diabetes", "Type 2 diabetes", "Type II diabetes" ; oboInOwl:hasRelatedSynonym "Diabetes mellitus type 2", "Noninsulin-dependent diabetes mellitus" ; oboInOwl:id "HP:0005978" ; a owl:Class ; rdfs:comment "Persons with type II diabetes mellitus rarely develop ketoacidosis." ; rdfs:label "Type II diabetes mellitus" ; rdfs:subClassOf obo:HP_0000819 . obo:HP_0005979 obo:IAO_0000115 "A metabolic acidosis due to accumulation of ketone bodies generally observed in the setting of poor nutritional intake." ; oboInOwl:hasAlternativeId "HP:0005971" ; oboInOwl:hasDbXref "MSH:D007662", "UMLS:C1854704" ; oboInOwl:hasExactSynonym "Starvation ketoacidosis" ; oboInOwl:id "HP:0005979" ; a owl:Class ; rdfs:label "Metabolic ketoacidosis" ; rdfs:subClassOf obo:HP_0001942, obo:HP_0001993 . obo:HP_0005982 obo:IAO_0000115 "A reduction in phenylalanine 4-monooxygenase level." ; oboInOwl:hasDbXref "MSH:D010661", "SNOMEDCT_US:7573000", "UMLS:C0751434", "UMLS:C4025094" ; oboInOwl:hasRelatedSynonym "Phenylalanine hydroxylase deficiency" ; oboInOwl:id "HP:0005982" ; a owl:Class ; rdfs:label "Reduced phenylalanine hydroxylase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000012234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005984 obo:IAO_0000115 "An elevation of alpha-feto protein in the maternal serum." ; oboInOwl:hasDbXref "UMLS:C0740927" ; oboInOwl:id "HP:0005984" ; a owl:Class ; rdfs:label "Elevated maternal serum alpha-fetoprotein" ; rdfs:subClassOf obo:HP_0006254 . obo:HP_0005986 oboInOwl:hasBroadSynonym "Limited neck mobility" ; oboInOwl:hasDbXref "MSH:D009127", "SNOMEDCT_US:161882006", "SNOMEDCT_US:405947006", "UMLS:C0151315", "UMLS:C1320474", "UMLS:C1847392" ; oboInOwl:hasExactSynonym "Limitation of neck motion", "Restricted neck movement" ; oboInOwl:id "HP:0005986" ; a owl:Class ; rdfs:label "Limitation of neck motion" ; rdfs:subClassOf obo:HP_0025669 . obo:HP_0005987 obo:IAO_0000115 "Enlargement of the thyroid gland related to multiple nodules in the thyroid gland." ; oboInOwl:hasDbXref "SNOMEDCT_US:237570007", "UMLS:C0342208" ; oboInOwl:hasExactSynonym "Multinodular goitre" ; oboInOwl:id "HP:0005987" ; a owl:Class ; rdfs:label "Multinodular goiter" ; rdfs:subClassOf obo:HP_0005994 . obo:HP_0005988 obo:IAO_0000115 "A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending." ; oboInOwl:hasDbXref "MSH:C535425", "SNOMEDCT_US:268240006", "UMLS:C0079352" ; oboInOwl:hasExactSynonym "Torticollis, congenital" ; oboInOwl:id "HP:0005988" ; a owl:Class ; rdfs:comment "Congenital muscular torticollis is thought to result from injury to the sternocleidomastoid muscle during birth trauma, resulting in fibrosis and unilateral shortening of the sternocleidomastoid muscle. Congenital muscular torticollis is thus etiologically and phenotypically distinct from spasmodic torticollis." ; rdfs:label "Congenital muscular torticollis" ; rdfs:subClassOf obo:HP_0011006 . obo:HP_0005989 obo:IAO_0000115 "Excess skin around the neck, often lying in horizontal folds." ; oboInOwl:hasAlternativeId "HP:0005993", "HP:0005996" ; oboInOwl:hasDbXref "UMLS:C1840319" ; oboInOwl:hasExactSynonym "Excess neck skin", "Excess skin over the neck", "Excessive nuchal skin", "Redundant neck skin", "Redundant nuchal skin", "Redundant skin folds of neck", "Redundant skin over the neck" ; oboInOwl:id "HP:0005989" ; a owl:Class ; rdfs:comment "With age and increased vertical growth of the neck, excess nuchal skin may disappear and the neck may become broad or webbed. If the skin folds are vertical or paravertical, the term Neck webbing should be used." ; rdfs:label "Redundant neck skin" ; rdfs:subClassOf obo:HP_0001582, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001582 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005990 obo:IAO_0000115 "Developmental hypoplasia of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D050033", "SNOMEDCT_US:367524008", "UMLS:C0151516" ; oboInOwl:hasExactSynonym "Hypoplastic thyroid", "Small thyroid gland" ; oboInOwl:id "HP:0005990" ; a owl:Class ; rdfs:label "Thyroid hypoplasia" ; rdfs:subClassOf obo:HP_0033079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005991 obo:IAO_0000115 "Reduced abilty to lower the chin towards the chest by bending the neck." ; oboInOwl:hasDbXref "UMLS:C1864449" ; oboInOwl:hasExactSynonym "Limited cervical flexion", "Limited neck flexibility" ; oboInOwl:id "HP:0005991" ; a owl:Class ; rdfs:label "Limited neck flexion" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0005994 obo:IAO_0000115 "Enlargement of the thyroid gland related to one or more nodules in the thyroid gland." ; oboInOwl:hasDbXref "MSH:D006044", "SNOMEDCT_US:419153005", "UMLS:C0018023" ; oboInOwl:hasExactSynonym "Nodular goitre" ; oboInOwl:id "HP:0005994" ; a owl:Class ; rdfs:label "Nodular goiter" ; rdfs:subClassOf obo:HP_0000853 . obo:HP_0005995 obo:IAO_0000115 "Reduced amount of adipose tissue in the region of the neck." ; oboInOwl:hasDbXref "UMLS:C1837763" ; oboInOwl:hasExactSynonym "Loss of adipose tissue around the neck", "Loss of fat around neck" ; oboInOwl:id "HP:0005995" ; a owl:Class ; rdfs:label "Decreased adipose tissue around neck" ; rdfs:subClassOf obo:HP_0003758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0005997 oboInOwl:hasDbXref "UMLS:C1867006" ; oboInOwl:hasExactSynonym "Neck joint contracture", "Restricted neck mobility due to contractures", "Restricted neck movement due to contractures" ; oboInOwl:id "HP:0005997" ; a owl:Class ; rdfs:label "Neck joint contracture" ; rdfs:subClassOf obo:HP_0001371, obo:HP_0005986 . obo:HP_0005999 obo:IAO_0000115 "A developmental defect defined by the failure of the formation of the lumen (tube) of the ureter." ; oboInOwl:hasDbXref "SNOMEDCT_US:204974003", "SNOMEDCT_US:49534003", "UMLS:C0266320" ; oboInOwl:id "HP:0005999" ; a owl:Class ; rdfs:label "Ureteral atresia" ; rdfs:subClassOf obo:HP_0025633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006000 obo:IAO_0000115 "Obstruction of the flow of urine through the ureter." ; oboInOwl:hasDbXref "Fyler:4492", "MSH:D014517", "SNOMEDCT_US:20018005", "UMLS:C0041956" ; oboInOwl:id "HP:0006000" ; a owl:Class ; rdfs:label "Ureteral obstruction" ; rdfs:subClassOf obo:HP_0025634 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006006 oboInOwl:hasDbXref "UMLS:C1843228" ; oboInOwl:hasExactSynonym "Degeneration of small hand muscles" ; oboInOwl:id "HP:0006006" ; a owl:Class ; rdfs:label "Hypotrophy of the small hand muscles" ; rdfs:subClassOf obo:HP_0001421 . obo:HP_0006008 oboInOwl:hasBroadSynonym "Short digits on one side" ; oboInOwl:hasDbXref "UMLS:C1868164", "UMLS:C4280467" ; oboInOwl:id "HP:0006008" ; a owl:Class ; rdfs:label "Unilateral brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0006009 obo:IAO_0000115 "Increased side-to-side width of one or more phalanges of the fingers or toes." ; oboInOwl:hasAlternativeId "HP:0006030", "HP:0006249" ; oboInOwl:hasDbXref "UMLS:C1855185" ; oboInOwl:hasExactSynonym "Broad phalanges", "Wide digital bones", "Wide phalanges", "Widened phalanges" ; oboInOwl:id "HP:0006009" ; a owl:Class ; rdfs:label "Broad phalanx" ; rdfs:subClassOf obo:HP_0005622, obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006011 obo:IAO_0000115 "Severely shortened metacarpal with a cuboidal appearance." ; oboInOwl:hasDbXref "UMLS:C4025093" ; oboInOwl:hasExactSynonym "Short, cube shaped long bone of hand" ; oboInOwl:id "HP:0006011" ; a owl:Class ; rdfs:comment "The metacarpals are normally tubular in appearance." ; rdfs:label "Cuboidal metacarpal" ; rdfs:subClassOf obo:HP_0010049 . obo:HP_0006012 oboInOwl:hasDbXref "UMLS:C1850159" ; oboInOwl:hasExactSynonym "Broad shaft of long bone of hand" ; oboInOwl:id "HP:0006012" ; a owl:Class ; rdfs:label "Widened metacarpal shaft" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0006014 oboInOwl:hasDbXref "UMLS:C1860111" ; oboInOwl:hasExactSynonym "Abnormally shaped wrist bones" ; oboInOwl:id "HP:0006014" ; a owl:Class ; rdfs:label "Abnormally shaped carpal bones" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006016 obo:IAO_0000115 "Delay in the process of formation and maturation of the epiphysis of one or more phalanx." ; oboInOwl:hasDbXref "UMLS:C4021609" ; oboInOwl:hasExactSynonym "Delayed phalangeal epiphyseal bone maturation" ; oboInOwl:hasRelatedSynonym "Delayed bone maturation of end part of digital bone" ; oboInOwl:id "HP:0006016" ; a owl:Class ; rdfs:label "Delayed phalangeal epiphyseal ossification" ; rdfs:subClassOf obo:HP_0002663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004446 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006019 oboInOwl:hasDbXref "UMLS:C1861396" ; oboInOwl:hasExactSynonym "Decreased space in hinge joint" ; oboInOwl:id "HP:0006019" ; a owl:Class ; rdfs:label "Reduced proximal interphalangeal joint space" ; rdfs:subClassOf obo:HP_0006261 . obo:HP_0006026 oboInOwl:hasDbXref "UMLS:C1850632" ; oboInOwl:hasExactSynonym "Rounded end part of bone" ; oboInOwl:id "HP:0006026" ; a owl:Class ; rdfs:label "Rounded epiphyses" ; rdfs:subClassOf obo:HP_0005924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000411 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006028 obo:IAO_0000115 "Metaphyseal cupping affecting the metacarpal bones." ; oboInOwl:hasAlternativeId "HP:0006131" ; oboInOwl:hasDbXref "UMLS:C1855171" ; oboInOwl:hasExactSynonym "Cupping of wide portion of long bone of hand", "Metacarpal/metaphyseal cupping" ; oboInOwl:id "HP:0006028" ; a owl:Class ; rdfs:label "Metaphyseal cupping of metacarpals" ; rdfs:subClassOf obo:HP_0003021 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006035 oboInOwl:hasDbXref "UMLS:C1857005" ; oboInOwl:hasExactSynonym "Cone-shaped end part of digital bones 2 to 5" ; oboInOwl:id "HP:0006035" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of phalanges 2 to 5" ; rdfs:subClassOf obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009384 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009395 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009412 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006040 oboInOwl:hasDbXref "UMLS:C1861531" ; oboInOwl:hasExactSynonym "Long 2nd long bone of hand" ; oboInOwl:id "HP:0006040" ; a owl:Class ; rdfs:label "Long second metacarpal" ; rdfs:subClassOf obo:HP_0010036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006042 obo:IAO_0000115 "Y-shaped metacarpals are the result of a partial fusion of two metacarpal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metacarpals may be seen in combination with polydactyly." ; oboInOwl:hasDbXref "UMLS:C1861373" ; oboInOwl:hasExactSynonym "Y-shaped long bone of hand" ; oboInOwl:id "HP:0006042" ; a owl:Class ; rdfs:label "Y-shaped metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001201 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006045 oboInOwl:hasDbXref "UMLS:C1849740" ; oboInOwl:hasExactSynonym "Short pointed digital bones" ; oboInOwl:id "HP:0006045" ; a owl:Class ; rdfs:label "Short pointed phalanges" ; rdfs:subClassOf obo:HP_0009803 . obo:HP_0006048 obo:IAO_0000115 "Abnormal increase in width of the distal region of the metacarpal bones." ; oboInOwl:hasDbXref "UMLS:C1865254" ; oboInOwl:hasExactSynonym "Wide outermost end of long bone" ; oboInOwl:id "HP:0006048" ; a owl:Class ; rdfs:label "Distal widening of metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006051 oboInOwl:hasDbXref "UMLS:C1834347" ; oboInOwl:id "HP:0006051" ; a owl:Class ; rdfs:label "Metacarpal periosteal thickening" ; rdfs:subClassOf obo:HP_0005916, obo:HP_0030313 . obo:HP_0006055 oboInOwl:hasDbXref "UMLS:C1833881" ; oboInOwl:id "HP:0006055" ; a owl:Class ; rdfs:label "Ulnar deviated club hands" ; rdfs:subClassOf obo:HP_0009487 . obo:HP_0006059 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the metacarpal bones, producing a 'ball-in-a-socket' appearance. This epiphyses are located at the distal ends of the metacarpal bones." ; oboInOwl:hasDbXref "UMLS:C1855239" ; oboInOwl:hasExactSynonym "Cone-shaped end part of long bone" ; oboInOwl:hasRelatedSynonym "Metacarpal cone-shaped epiphyses" ; oboInOwl:id "HP:0006059" ; a owl:Class ; rdfs:label "Cone-shaped metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006060 oboInOwl:hasDbXref "UMLS:C1862420" ; oboInOwl:hasExactSynonym "Tombstone-shaped innermost digital bones" ; oboInOwl:id "HP:0006060" ; a owl:Class ; rdfs:label "Tombstone-shaped proximal phalanges" ; rdfs:subClassOf obo:HP_0009834 . obo:HP_0006064 oboInOwl:hasDbXref "UMLS:C1840089" ; oboInOwl:hasExactSynonym "Limited movement of hinge joints" ; oboInOwl:id "HP:0006064" ; a owl:Class ; rdfs:label "Limited interphalangeal movement" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0006261 . obo:HP_0006067 obo:IAO_0000115 "A delay in the process of formation and maturation of the epiphysis of one or more long bones." ; oboInOwl:hasDbXref "UMLS:C1835573" ; oboInOwl:hasExactSynonym "Multiple carpal ossification centres" ; oboInOwl:id "HP:0006067" ; a owl:Class ; rdfs:label "Multiple carpal ossification centers" ; rdfs:subClassOf obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006069 obo:IAO_0100001 "HP:0001216" ; oboInOwl:id "HP:0006069" ; a owl:Class ; rdfs:label "obsolete Severe carpal ossification delay" ; owl:deprecated true . obo:HP_0006070 obo:IAO_0000115 "A chronic loss of joint motion in metacarpophalangeal joints due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." ; oboInOwl:hasAlternativeId "HP:0005674" ; oboInOwl:hasDbXref "UMLS:C2677209" ; oboInOwl:hasExactSynonym "Metacarpal/phalangeal joint contractures" ; oboInOwl:id "HP:0006070" ; a owl:Class ; rdfs:comment "In the literature this has been called metacarpophalangeal camptodactyly, but the term camptodactyly should be researved for a painless flexion contracture of the proximal interphalangeal (PIP) joint." ; rdfs:label "Metacarpophalangeal joint contracture" ; rdfs:subClassOf obo:HP_0011911 . obo:HP_0006077 obo:IAO_0000115 "Absence of the proximal interphalangeal flexion creases of the fingers." ; oboInOwl:hasDbXref "UMLS:C1850048" ; oboInOwl:id "HP:0006077" ; a owl:Class ; rdfs:label "Absent proximal finger flexion creases" ; rdfs:subClassOf obo:HP_0006109 . obo:HP_0006086 oboInOwl:hasDbXref "UMLS:C1850160" ; oboInOwl:id "HP:0006086" ; a owl:Class ; rdfs:label "Thin metacarpal cortices" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0006088 oboInOwl:hasDbXref "UMLS:C1861357" ; oboInOwl:id "HP:0006088" ; a owl:Class ; rdfs:label "1-5 finger complete cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010554 . obo:HP_0006089 oboInOwl:hasDbXref "UMLS:C1856953" ; oboInOwl:hasExactSynonym "Excessive sweating of hands" ; oboInOwl:id "HP:0006089" ; a owl:Class ; rdfs:label "Palmar hyperhidrosis" ; rdfs:subClassOf obo:HP_0000975, obo:HP_0040211 . obo:HP_0006092 obo:IAO_0000115 "Malalignement of carpal bone angles either with respect to each other, to the corresponding metacarpals or with respect to the wrist (radius and ulna)." ; oboInOwl:hasDbXref "UMLS:C1856742" ; oboInOwl:hasExactSynonym "Incorrect alignment of wrist bone" ; oboInOwl:id "HP:0006092" ; a owl:Class ; rdfs:label "Malaligned carpal bone" ; rdfs:subClassOf obo:HP_0001191 . obo:HP_0006094 oboInOwl:hasDbXref "SNOMEDCT_US:298193009", "UMLS:C0574974" ; oboInOwl:hasExactSynonym "Increased mobility in finger joint" ; oboInOwl:id "HP:0006094" ; a owl:Class ; rdfs:label "Finger joint hypermobility" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0001382, obo:HP_0006256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006095 oboInOwl:hasDbXref "UMLS:C1835101" ; oboInOwl:hasExactSynonym "Wide tips of outermost digital bone" ; oboInOwl:id "HP:0006095" ; a owl:Class ; rdfs:label "Wide tufts of distal phalanges" ; rdfs:subClassOf obo:HP_0006200 . obo:HP_0006097 obo:IAO_0000115 "Syndactyly with fusion of fingers three and four." ; oboInOwl:hasAlternativeId "HP:0006133" ; oboInOwl:hasDbXref "UMLS:C1856889" ; oboInOwl:hasExactSynonym "Partial or complete syndactyly 3rd-4th fingers", "Webbed 3rd-4th finger", "Webbed 3rd-4th fingers" ; oboInOwl:id "HP:0006097" ; a owl:Class ; rdfs:label "3-4 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006099 obo:IAO_0000115 "Increased mobility of one ore more metacarpophalangeal joint." ; oboInOwl:hasDbXref "UMLS:C4025092" ; oboInOwl:id "HP:0006099" ; a owl:Class ; rdfs:label "Metacarpophalangeal joint hyperextensibility" ; rdfs:subClassOf obo:HP_0011911 . obo:HP_0006101 obo:IAO_0000115 "Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as \"Symphalangism\"." ; oboInOwl:hasAlternativeId "HP:0006057" ; oboInOwl:hasDbXref "SNOMEDCT_US:249769001", "SNOMEDCT_US:268251006", "SNOMEDCT_US:34048007", "UMLS:C0221352" ; oboInOwl:hasExactSynonym "Partial syndactyly" ; oboInOwl:id "HP:0006101" ; a owl:Class ; rdfs:label "Finger syndactyly" ; rdfs:subClassOf obo:HP_0001159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006106 oboInOwl:hasDbXref "UMLS:C1847191" ; oboInOwl:id "HP:0006106" ; a owl:Class ; rdfs:label "Absent trapezoid bone" ; rdfs:subClassOf obo:HP_0004256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006107 obo:IAO_0000115 "Telangiectasia (small dilated blood vessels) located in the fingerpads at the tips of the fingers." ; oboInOwl:hasAlternativeId "HP:0006246" ; oboInOwl:hasDbXref "UMLS:C1861248" ; oboInOwl:hasExactSynonym "Finger pad telangiectases", "Small dilated blood vessels in fingerpads" ; oboInOwl:id "HP:0006107" ; a owl:Class ; rdfs:label "Fingerpad telangiectases" ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0006108 obo:IAO_0000115 "Metacarpal that becomes thinner toward the distal end." ; oboInOwl:hasDbXref "UMLS:C4025091" ; oboInOwl:hasExactSynonym "Tapered long bones of hand" ; oboInOwl:id "HP:0006108" ; a owl:Class ; rdfs:label "Tapered metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006109 obo:IAO_0000115 "Absence of one or more interphalangeal creases (i.e., of the transverse lines in the skin between the phalanges of the fingers)." ; oboInOwl:hasAlternativeId "HP:0006031" ; oboInOwl:hasDbXref "UMLS:C1862479", "UMLS:C4020821" ; oboInOwl:hasExactSynonym "Absent interphalangeal creases" ; oboInOwl:hasRelatedSynonym "Aplasia of the interphalangeal creases" ; oboInOwl:id "HP:0006109" ; a owl:Class ; rdfs:label "Absent phalangeal crease" ; rdfs:subClassOf obo:HP_0006143 . obo:HP_0006110 obo:IAO_0000115 "Short, hypoplastic middle phalanx of finger, affecting all fingers." ; oboInOwl:hasDbXref "UMLS:C1856912" ; oboInOwl:id "HP:0006110" ; a owl:Class ; rdfs:label "Shortening of all middle phalanges of the fingers" ; rdfs:subClassOf obo:HP_0005819 . obo:HP_0006112 oboInOwl:hasDbXref "UMLS:C1969287" ; oboInOwl:id "HP:0006112" ; a owl:Class ; rdfs:label "Expanded phalanges with widened medullary cavities" ; rdfs:subClassOf obo:HP_0009768 . obo:HP_0006114 obo:IAO_0000115 "The presence of multiple creases on the palm of the hand (more than the normal three major creases (distal transverse crease, proximal transverse crease, and thenar crease)." ; oboInOwl:hasDbXref "UMLS:C1861872" ; oboInOwl:hasExactSynonym "Multiple palm lines" ; oboInOwl:id "HP:0006114" ; a owl:Class ; rdfs:label "Multiple palmar creases" ; rdfs:subClassOf obo:HP_0010490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006118 obo:IAO_0000115 "Hypoplasia of all of the distal phalanx of finger." ; oboInOwl:hasAlternativeId "HP:0005658" ; oboInOwl:hasDbXref "UMLS:C4021608" ; oboInOwl:hasExactSynonym "Shortening of all outermost bones of the fingers" ; oboInOwl:hasRelatedSynonym "Brachytelephalangy" ; oboInOwl:id "HP:0006118" ; a owl:Class ; rdfs:label "Shortening of all distal phalanges of the fingers" ; rdfs:subClassOf obo:HP_0009882 . obo:HP_0006119 obo:IAO_0000115 "Some or all of the metacarpal bones (i.e., metacarpal II to V) have a pointed proximal appearance." ; oboInOwl:hasDbXref "UMLS:C1854749" ; oboInOwl:hasExactSynonym "Pointed innermost long bone of hand", "Pointed proximal metacarpals" ; oboInOwl:id "HP:0006119" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Proximal tapering of metacarpals" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0006121 obo:IAO_0000115 "A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe." ; oboInOwl:hasAlternativeId "HP:0001226", "HP:0001862", "HP:0005040" ; oboInOwl:hasDbXref "UMLS:C1860099" ; oboInOwl:id "HP:0006121" ; a owl:Class ; rdfs:label "Acral ulceration" ; rdfs:subClassOf obo:HP_0031917 . obo:HP_0006127 obo:IAO_0000115 "Increased length of the proximal phalanx of finger." ; oboInOwl:hasDbXref "UMLS:C4025090" ; oboInOwl:hasExactSynonym "Long innermost finger bone" ; oboInOwl:id "HP:0006127" ; a owl:Class ; rdfs:label "Long proximal phalanx of finger" ; rdfs:subClassOf obo:HP_0006155, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006129 obo:IAO_0000115 "Rounding and broadening of the tufts of the distal phalanges." ; oboInOwl:hasDbXref "UMLS:C1844822" ; oboInOwl:hasExactSynonym "Drumstick shaped digital bones" ; oboInOwl:id "HP:0006129" ; a owl:Class ; rdfs:comment "This designation is supposed to refer to the widening of the meaty end of a chicken drumstick (lower leg)." ; rdfs:label "Drumstick terminal phalanges" ; rdfs:subClassOf obo:HP_0009832 . obo:HP_0006134 obo:IAO_0000115 "Abnormally large size of one or more growth plates (epiphyses) of the metacarpal bones (i.e., the tubular bones of the hand between the carpus and the phalanges)." ; oboInOwl:hasDbXref "UMLS:C1865035" ; oboInOwl:hasExactSynonym "Enlarged end part of long bone of hand" ; oboInOwl:id "HP:0006134" ; a owl:Class ; rdfs:label "Enlarged metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006135 oboInOwl:hasDbXref "UMLS:C1862133" ; oboInOwl:hasExactSynonym "Decreased finger mobility", "Decreased finger movement" ; oboInOwl:id "HP:0006135" ; a owl:Class ; rdfs:label "Decreased finger mobility" ; rdfs:subClassOf obo:HP_0006256 . obo:HP_0006136 oboInOwl:hasDbXref "UMLS:C1855003" ; oboInOwl:id "HP:0006136" ; a owl:Class ; rdfs:label "Bilateral postaxial polydactyly" ; rdfs:subClassOf obo:HP_0001162 . obo:HP_0006140 obo:IAO_0000115 "Fusion of the epiphysis and metaphysis of one or more phalanges prior to the normal age or stage of growth." ; oboInOwl:hasDbXref "UMLS:C1855620" ; oboInOwl:hasExactSynonym "Premature fusion of end part of digital bone" ; oboInOwl:id "HP:0006140" ; a owl:Class ; rdfs:label "Premature fusion of phalangeal epiphyses" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010656 . obo:HP_0006143 obo:IAO_0000115 "Anomalous flexion crease (i.e., a transverse line that crosses the skin of a finger)." ; oboInOwl:hasDbXref "UMLS:C1859481" ; oboInOwl:hasExactSynonym "Abnormal finger flexion creases" ; oboInOwl:id "HP:0006143" ; a owl:Class ; rdfs:label "Abnormal finger flexion crease" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0006144 obo:IAO_0000115 "Congenital hypoplasia of proximal phalanx of finger or all fingers." ; oboInOwl:hasAlternativeId "HP:0006021" ; oboInOwl:hasDbXref "UMLS:C4025089" ; oboInOwl:hasExactSynonym "Shortening of all innermost bones of the fingers" ; oboInOwl:id "HP:0006144" ; a owl:Class ; rdfs:label "Shortening of all proximal phalanges of the fingers" ; rdfs:subClassOf obo:HP_0010241 . obo:HP_0006145 obo:IAO_0000115 "A central Y-shaped metacarpal is the result of a partial fusion of two central metacarpals (i.e., metacarpals 2-4) of the hand, with the two arms of the Y pointing in the distal direction. Central Y-shaped metacarpals may be seen as a result of a central polydactyly with partial fusion of the duplicated metacarpal." ; oboInOwl:hasDbXref "UMLS:C1848597" ; oboInOwl:hasExactSynonym "Y-shaped central long bones of hand" ; oboInOwl:id "HP:0006145" ; a owl:Class ; rdfs:label "Central Y-shaped metacarpal" ; rdfs:subClassOf obo:HP_0006042 . obo:HP_0006146 obo:IAO_0000115 "Increased side-to-side width of the metacarpal epiphyses." ; oboInOwl:hasDbXref "UMLS:C4025088" ; oboInOwl:hasExactSynonym "Broad end part of long bone of hand" ; oboInOwl:id "HP:0006146" ; a owl:Class ; rdfs:label "Broad metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0005913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006147 oboInOwl:hasDbXref "UMLS:C1861310" ; oboInOwl:id "HP:0006147" ; a owl:Class ; rdfs:label "Progressive fusion 2nd-5th pip joints" ; rdfs:subClassOf obo:HP_0009773 . obo:HP_0006149 oboInOwl:hasDbXref "UMLS:C1850855" ; oboInOwl:id "HP:0006149" ; a owl:Class ; rdfs:label "Increased laxity of fingers" ; rdfs:subClassOf obo:HP_0006094 . obo:HP_0006150 obo:IAO_0000115 "A swan neck deformity describes a finger with a hyperextended PIP joint and a flexed DIP joint. The most common cause for a swan neck-like deformity is a disruption of the end of the extensor tendon. Conditions that loosen the PIP joint and allow it to hyperextend, for example conditions that weaken the volar plate, can produce a swan neck deformity of the finger. One example is rheumatoid arthritis. Another cause are conditions that tighten up the small (intrinsic) muscles of the hand and fingers, for example hand trauma or nerve disorders, such as cerebral palsy, Parkinson's disease, or stroke." ; oboInOwl:hasDbXref "UMLS:C1849152" ; oboInOwl:id "HP:0006150" ; a owl:Class ; rdfs:label "Swan neck-like deformities of the fingers" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0006152 obo:IAO_0000115 "The term proximal symphalangism refers to a bony fusion of the middle and proximal phalanges of the digits of the hand, in other words the proximal interphalangeal joint (PIJ) is missing which can be seen either on x-rays or as an absence of the proximal interphalangeal finger creases." ; oboInOwl:hasAlternativeId "HP:0006005" ; oboInOwl:hasDbXref "UMLS:C4021607" ; oboInOwl:hasExactSynonym "Fused innermost hinge joints", "Proximal interphalangeal joint synostoses" ; oboInOwl:id "HP:0006152" ; a owl:Class ; rdfs:label "Proximal symphalangism of hands" ; rdfs:subClassOf obo:HP_0009700, obo:HP_0009773, obo:HP_0100264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006153 oboInOwl:hasDbXref "UMLS:C2675549" ; oboInOwl:hasExactSynonym "Disharmonious wrist bone" ; oboInOwl:id "HP:0006153" ; a owl:Class ; rdfs:label "Disharmonious carpal bone" ; rdfs:subClassOf obo:HP_0006014 . obo:HP_0006155 obo:IAO_0000115 "Increased length of multiple or a single phalanx of finger." ; oboInOwl:hasDbXref "UMLS:C4025087" ; oboInOwl:hasExactSynonym "Long finger bone" ; oboInOwl:id "HP:0006155" ; a owl:Class ; rdfs:label "Long phalanx of finger" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006156 obo:IAO_0000115 "Bending or curvature of a thumb towards the ulnar side (towards the ring finger)." ; oboInOwl:hasBroadSynonym "Curved thumb deviated towards palm" ; oboInOwl:hasDbXref "SNOMEDCT_US:299137000", "UMLS:C0575904", "UMLS:C4280465" ; oboInOwl:hasExactSynonym "Ulnar deviation of the 1st finger" ; oboInOwl:id "HP:0006156" ; a owl:Class ; rdfs:label "Ulnar deviation of thumb" ; rdfs:subClassOf obo:HP_0009465, obo:HP_0009603 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006157 oboInOwl:hasBroadSynonym "Prominent life line" ; oboInOwl:hasDbXref "UMLS:C1865131", "UMLS:C4280464" ; oboInOwl:id "HP:0006157" ; a owl:Class ; rdfs:label "Prominent palmar flexion creases" ; rdfs:subClassOf obo:HP_0010490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006158 oboInOwl:id "HP:0006158" ; a owl:Class ; rdfs:label "obsolete Finger joint hyperextensibility" ; owl:deprecated true . obo:HP_0006159 obo:IAO_0000115 "The presence of a supernumerary finger (not a thumb) involving the third or fourth metacarpal with associated osseous syndactyly." ; oboInOwl:hasAlternativeId "HP:0001496", "HP:0004056" ; oboInOwl:hasDbXref "UMLS:C4021606" ; oboInOwl:hasExactSynonym "Interdigital finger polydactyly" ; oboInOwl:hasRelatedSynonym "Central hand polydactyly" ; oboInOwl:id "HP:0006159" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Mesoaxial hand polydactyly" ; rdfs:subClassOf obo:HP_0001161, obo:HP_0100260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0019232 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006160 obo:IAO_0000115 "Irregular morphology of one or more metacarpal bones." ; oboInOwl:hasDbXref "UMLS:C4025086" ; oboInOwl:hasExactSynonym "Irregular long bones of hand" ; oboInOwl:id "HP:0006160" ; a owl:Class ; rdfs:label "Irregular metacarpals" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0006161 oboInOwl:hasDbXref "UMLS:C1856471" ; oboInOwl:hasExactSynonym "Short long bone of hand with rounded innermost ends" ; oboInOwl:id "HP:0006161" ; a owl:Class ; rdfs:label "Short metacarpals with rounded proximal ends" ; rdfs:subClassOf obo:HP_0010049 . obo:HP_0006162 oboInOwl:hasDbXref "UMLS:C1854913" ; oboInOwl:hasExactSynonym "Soft tissue swelling of hinge joints" ; oboInOwl:id "HP:0006162" ; a owl:Class ; rdfs:label "Soft tissue swelling of interphalangeal joints" ; rdfs:subClassOf obo:HP_0006261 . obo:HP_0006163 oboInOwl:hasDbXref "UMLS:C1859700" ; oboInOwl:id "HP:0006163" ; a owl:Class ; rdfs:label "Enlarged metacarpophalangeal joints" ; rdfs:subClassOf obo:HP_0006261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003695 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006165 oboInOwl:hasDbXref "UMLS:C1862157" ; oboInOwl:hasExactSynonym "Proportionate shortening of all digits" ; oboInOwl:id "HP:0006165" ; a owl:Class ; rdfs:label "Proportionate shortening of all digits" ; rdfs:subClassOf obo:HP_0006265 . obo:HP_0006166 oboInOwl:hasDbXref "UMLS:C1859369" ; oboInOwl:hasExactSynonym "Cylindrical shaped long bones of hand" ; oboInOwl:id "HP:0006166" ; a owl:Class ; rdfs:label "Tubular metacarpal bones" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001873 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006167 oboInOwl:hasDbXref "UMLS:C4025085" ; oboInOwl:hasExactSynonym "Prominent innermost hinge joints" ; oboInOwl:id "HP:0006167" ; a owl:Class ; rdfs:label "Prominent proximal interphalangeal joints" ; rdfs:subClassOf obo:HP_0006237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006169 oboInOwl:hasDbXref "UMLS:C1833882" ; oboInOwl:hasExactSynonym "Decreased mobility 3rd-5th fingers" ; oboInOwl:id "HP:0006169" ; a owl:Class ; rdfs:label "Decreased mobility 3rd-5th fingers" ; rdfs:subClassOf obo:HP_0006135 . obo:HP_0006170 obo:IAO_0000115 "A morphological abnormality of distal phalanges such that they have the appearance of chess pawns." ; oboInOwl:hasDbXref "UMLS:C1862097" ; oboInOwl:hasExactSynonym "Chess-pawn shaped outermost bone" ; oboInOwl:id "HP:0006170" ; a owl:Class ; rdfs:label "Chess-pawn distal phalanges" ; rdfs:subClassOf obo:HP_0009832 . obo:HP_0006172 oboInOwl:hasDbXref "UMLS:C1834961" ; oboInOwl:hasExactSynonym "Flattened, squared-off end part of tubular bones" ; oboInOwl:id "HP:0006172" ; a owl:Class ; rdfs:label "Flattened, squared-off epiphyses of tubular bones" ; rdfs:subClassOf obo:HP_0003053, obo:HP_0003071 . obo:HP_0006174 obo:IAO_0000115 "Increase in bone density in the diaphyseal (shaft) region of a metacarpal bone." ; oboInOwl:hasDbXref "UMLS:C1840419" ; oboInOwl:id "HP:0006174" ; a owl:Class ; rdfs:label "Metacarpal diaphyseal endosteal sclerosis" ; rdfs:subClassOf obo:HP_0005916, obo:HP_0011001 . obo:HP_0006175 oboInOwl:hasBroadSynonym "Thickening of connective tissue of innermost finger bone" ; oboInOwl:hasDbXref "UMLS:C1834348", "UMLS:C4280463" ; oboInOwl:id "HP:0006175" ; a owl:Class ; rdfs:label "Proximal phalangeal periosteal thickening" ; rdfs:subClassOf obo:HP_0009834, obo:HP_0030313 . obo:HP_0006176 oboInOwl:hasDbXref "UMLS:C1839285" ; oboInOwl:hasExactSynonym "Two carpal ossification centres present at birth" ; oboInOwl:id "HP:0006176" ; a owl:Class ; rdfs:label "Two carpal ossification centers present at birth" ; rdfs:subClassOf obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006179 oboInOwl:hasAlternativeId "HP:0010221" ; oboInOwl:hasDbXref "UMLS:C1862693" ; oboInOwl:hasExactSynonym "Extra bone on end of second long bone of hand", "Pseudoepiphysis of the 2nd metacarpal" ; oboInOwl:id "HP:0006179" ; a owl:Class ; rdfs:label "Pseudoepiphyses of second metacarpal" ; rdfs:subClassOf obo:HP_0009193, obo:HP_0010220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006180 oboInOwl:hasBroadSynonym "Crowded wrist bones" ; oboInOwl:hasDbXref "UMLS:C1863317" ; oboInOwl:id "HP:0006180" ; a owl:Class ; rdfs:label "Crowded carpal bones" ; rdfs:subClassOf obo:HP_0001191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000619 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006184 obo:IAO_0000115 "Poorly defined or shallow palmar creases." ; oboInOwl:hasAlternativeId "HP:0006178" ; oboInOwl:hasDbXref "UMLS:C1857483" ; oboInOwl:hasExactSynonym "Hypoplastic palmar creases", "Poorly formed palmar creases", "Shallow palm line", "Shallow palmar creases" ; oboInOwl:id "HP:0006184" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Decreased palmar creases" ; rdfs:subClassOf obo:HP_0010488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006185 oboInOwl:hasDbXref "UMLS:C1861350" ; oboInOwl:hasExactSynonym "Enlarged innermost hinge joint" ; oboInOwl:id "HP:0006185" ; a owl:Class ; rdfs:label "Enlarged proximal interphalangeal joints" ; rdfs:subClassOf obo:HP_0006247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006187 obo:IAO_0100001 "HP:0009773" ; oboInOwl:id "HP:0006187" ; a owl:Class ; rdfs:label "obsolete Fusion of midphalangeal joints" ; owl:deprecated true . obo:HP_0006189 oboInOwl:hasDbXref "UMLS:C1866000" ; oboInOwl:id "HP:0006189" ; a owl:Class ; rdfs:label "Prominent interdigital folds" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0006190 oboInOwl:hasDbXref "UMLS:C1861316" ; oboInOwl:id "HP:0006190" ; a owl:Class ; rdfs:label "Radially deviated wrists" ; rdfs:subClassOf obo:HP_0009486 . obo:HP_0006191 obo:IAO_0000115 "Excessively deep creases of the palm." ; oboInOwl:hasDbXref "UMLS:C1857539" ; oboInOwl:hasExactSynonym "Deep palm line", "Deep palmar creases" ; oboInOwl:id "HP:0006191" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Deep palmar crease" ; rdfs:subClassOf obo:HP_0010490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006192 obo:IAO_0000115 "Phalanges of the fingers becoming thinner toward the distal end." ; oboInOwl:hasDbXref "UMLS:C4025084" ; oboInOwl:hasExactSynonym "Tapered finger bone" ; oboInOwl:id "HP:0006192" ; a owl:Class ; rdfs:label "Tapered phalanx of finger" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006193 obo:IAO_0000115 "The middle phalanx of finger resembles a thimble, a small metal cap to protect the finger while sewing that has a broad (proximal) base and narrower top, whereby both base and top are flat." ; oboInOwl:hasDbXref "UMLS:C4025083" ; oboInOwl:hasExactSynonym "Thimble-shaped middle bones of hand" ; oboInOwl:id "HP:0006193" ; a owl:Class ; rdfs:label "Thimble-shaped middle phalanges of hand" ; rdfs:subClassOf obo:HP_0009833 . obo:HP_0006200 oboInOwl:hasDbXref "UMLS:C1862421" ; oboInOwl:hasExactSynonym "Widened outermost bone of limb" ; oboInOwl:id "HP:0006200" ; a owl:Class ; rdfs:label "Widened distal phalanges" ; rdfs:subClassOf obo:HP_0006009 . obo:HP_0006201 oboInOwl:hasDbXref "UMLS:C1851811" ; oboInOwl:hasExactSynonym "Increased mobility of outermost hinge joint" ; oboInOwl:id "HP:0006201" ; a owl:Class ; rdfs:label "Hypermobility of distal interphalangeal joints" ; rdfs:subClassOf obo:HP_0005620 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009768 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006202 oboInOwl:hasDbXref "UMLS:C4025082" ; oboInOwl:id "HP:0006202" ; a owl:Class ; rdfs:label "Osteolysis of scaphoids" ; rdfs:subClassOf obo:HP_0004243, obo:HP_0009699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001427 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006203 oboInOwl:hasDbXref "UMLS:C1836772" ; oboInOwl:hasExactSynonym "Decreased range of movement range in hinge joints" ; oboInOwl:id "HP:0006203" ; a owl:Class ; rdfs:label "Decreased movement range in interphalangeal joints" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0006135 . obo:HP_0006205 obo:IAO_0000115 "Alteration of the normally smooth radiographic contour of phalanges producing an irregular appearance." ; oboInOwl:hasDbXref "UMLS:C4025081" ; oboInOwl:hasExactSynonym "Irregular finger bones" ; oboInOwl:id "HP:0006205" ; a owl:Class ; rdfs:label "Irregular phalanges" ; rdfs:subClassOf obo:HP_0005918 . obo:HP_0006206 obo:IAO_0000115 "Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the second finger." ; oboInOwl:hasDbXref "UMLS:C4025080" ; oboInOwl:id "HP:0006206" ; a owl:Class ; rdfs:comment "This anomaly is characteristic for brachydactyly type C." ; rdfs:label "Hypersegmentation of proximal phalanx of second finger" ; rdfs:subClassOf obo:HP_0009544 . obo:HP_0006207 oboInOwl:hasDbXref "UMLS:C1844519" ; oboInOwl:id "HP:0006207" ; a owl:Class ; rdfs:label "Partial fusion of carpals" ; rdfs:subClassOf obo:HP_0009702 . obo:HP_0006208 obo:IAO_0000115 "Metaphyseal cupping affecting the proximal phalanges." ; oboInOwl:hasDbXref "UMLS:C1834980" ; oboInOwl:id "HP:0006208" ; a owl:Class ; rdfs:label "Metaphyseal cupping of proximal phalanges" ; rdfs:subClassOf obo:HP_0003021 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006209 oboInOwl:hasDbXref "UMLS:C1867928" ; oboInOwl:hasExactSynonym "Partial-complete absence of 5th digital bone" ; oboInOwl:id "HP:0006209" ; a owl:Class ; rdfs:label "Partial-complete absence of 5th phalanges" ; rdfs:subClassOf obo:HP_0006262 . obo:HP_0006210 oboInOwl:hasDbXref "UMLS:C1867927" ; oboInOwl:id "HP:0006210" ; a owl:Class ; rdfs:label "Postaxial oligodactyly" ; rdfs:subClassOf obo:HP_0001180 . obo:HP_0006213 oboInOwl:hasBroadSynonym "Thin proximal phalanges with broad epiphyses" ; oboInOwl:hasDbXref "UMLS:C1862156", "UMLS:C4025079" ; oboInOwl:hasExactSynonym "Thin innermost bone with broad end part of the hand bone" ; oboInOwl:id "HP:0006213" ; a owl:Class ; rdfs:comment "removed the logical def: 'has part' some (('decreased thickness' and ('inheres in' some 'proximal phalanx of manus') and ('has modifier' some abnormal)) and ('has part' some ('increased width' and ('inheres in' some 'epiphysis of proximal phalanx of manus'))) and ('has modifier' some abnormal))" ; rdfs:label "Thin proximal phalanges with broad epiphyses of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0009834 . obo:HP_0006216 obo:IAO_0000115 "Presence of only one (instead of two, as normal) interphalangeal crease of the fifth finger." ; oboInOwl:hasAlternativeId "HP:0006245" ; oboInOwl:hasDbXref "UMLS:C1850336" ; oboInOwl:hasExactSynonym "Fifth finger single interphalangeal crease" ; oboInOwl:id "HP:0006216" ; a owl:Class ; rdfs:label "Single interphalangeal crease of fifth finger" ; rdfs:subClassOf obo:HP_0006109 . obo:HP_0006217 oboInOwl:hasDbXref "UMLS:C1857288" ; oboInOwl:hasExactSynonym "Limited mobility of innermost hinge joint" ; oboInOwl:id "HP:0006217" ; a owl:Class ; rdfs:label "Limited mobility of proximal interphalangeal joint" ; rdfs:subClassOf obo:HP_0006261 . obo:HP_0006224 obo:IAO_0000115 "A reduction in diameter of the distal phalanx of finger towards the distal end such that the tip of the phalanx comes to a point (this feature can be observed on radiograms)." ; oboInOwl:hasDbXref "UMLS:C4025078" ; oboInOwl:id "HP:0006224" ; a owl:Class ; rdfs:label "Tapering pointed ends of distal finger phalanges" ; rdfs:subClassOf obo:HP_0009884 . obo:HP_0006226 oboInOwl:hasDbXref "SNOMEDCT_US:37895003", "UMLS:C0409956" ; oboInOwl:id "HP:0006226" ; a owl:Class ; rdfs:label "Osteoarthritis of the first carpometacarpal joint" ; rdfs:subClassOf obo:HP_0004268 . obo:HP_0006228 oboInOwl:hasDbXref "UMLS:C1860179" ; oboInOwl:id "HP:0006228" ; a owl:Class ; rdfs:label "Valgus hand deformity" ; rdfs:subClassOf obo:HP_0005922 . obo:HP_0006230 oboInOwl:hasDbXref "UMLS:C3805861" ; oboInOwl:id "HP:0006230" ; a owl:Class ; rdfs:label "Unilateral oligodactyly" ; rdfs:subClassOf obo:HP_0001180 . obo:HP_0006232 oboInOwl:hasDbXref "UMLS:C1969288" ; oboInOwl:id "HP:0006232" ; a owl:Class ; rdfs:label "Expanded metacarpals with widened medullary cavities" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0006233 oboInOwl:hasDbXref "SNOMEDCT_US:239869009", "UMLS:C0409957" ; oboInOwl:id "HP:0006233" ; a owl:Class ; rdfs:label "Osteoarthritis of the distal interphalangeal joint" ; rdfs:subClassOf obo:HP_0004268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009768 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006234 obo:IAO_0000115 "An increased resorption of bone matrix by osteoclasts leading to bony defects involving the tarsal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:39:00Z" ; oboInOwl:hasAlternativeId "HP:0001858" ; oboInOwl:hasDbXref "UMLS:C1833735" ; oboInOwl:hasExactSynonym "Tarsal bone osteolysis", "Tarsal osteolysis" ; oboInOwl:id "HP:0006234" ; a owl:Class ; rdfs:label "Osteolysis involving tarsal bones" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0009134 . obo:HP_0006236 obo:IAO_0000115 "Decreased width of the metacarpal bones (that is, reduced diameter)." ; oboInOwl:hasDbXref "UMLS:C4025077" ; oboInOwl:hasExactSynonym "Slender long bones of hand" ; oboInOwl:id "HP:0006236" ; a owl:Class ; rdfs:label "Slender metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006237 oboInOwl:hasDbXref "UMLS:C1859115" ; oboInOwl:hasExactSynonym "Prominent hinge joints" ; oboInOwl:id "HP:0006237" ; a owl:Class ; rdfs:label "Prominent interphalangeal joints" ; rdfs:subClassOf obo:HP_0006261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006658 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006239 obo:IAO_0000115 "Abnormal shortening of all middle phalanges of toes." ; oboInOwl:hasDbXref "UMLS:C4021605" ; oboInOwl:hasExactSynonym "Brachymesophalangy of feet", "Shortening of all the middle bones of the toes" ; oboInOwl:id "HP:0006239" ; a owl:Class ; rdfs:label "Shortening of all middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0003795 . obo:HP_0006243 oboInOwl:hasDbXref "UMLS:C2673396" ; oboInOwl:id "HP:0006243" ; a owl:Class ; rdfs:label "Phalangeal dislocation" ; rdfs:subClassOf obo:HP_0001373, obo:HP_0005918 . obo:HP_0006247 oboInOwl:hasDbXref "UMLS:C1859701" ; oboInOwl:hasExactSynonym "Enlarged hinge joints" ; oboInOwl:id "HP:0006247" ; a owl:Class ; rdfs:label "Enlarged interphalangeal joints" ; rdfs:subClassOf obo:HP_0003037, obo:HP_0006261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006658 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006248 obo:IAO_0000115 "An abnormal limitation of the mobility of the wrist." ; oboInOwl:hasDbXref "UMLS:C1840088" ; oboInOwl:hasExactSynonym "Limited movement of the wrist", "Limited wrist movement" ; oboInOwl:id "HP:0006248" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limited wrist movement" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0003019 . obo:HP_0006251 oboInOwl:hasDbXref "UMLS:C1862481" ; oboInOwl:id "HP:0006251" ; a owl:Class ; rdfs:label "Limited wrist extension" ; rdfs:subClassOf obo:HP_0006248 . obo:HP_0006252 oboInOwl:hasDbXref "UMLS:C1850158" ; oboInOwl:id "HP:0006252" ; a owl:Class ; rdfs:label "Interphalangeal joint erosions" ; rdfs:subClassOf obo:HP_0006261 . obo:HP_0006253 oboInOwl:hasDbXref "UMLS:C1860841" ; oboInOwl:hasExactSynonym "Swelling of innermost hinge joints" ; oboInOwl:id "HP:0006253" ; a owl:Class ; rdfs:label "Swelling of proximal interphalangeal joints" ; rdfs:subClassOf obo:HP_0006261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001851 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006254 obo:IAO_0000115 "Concentration of alpha-fetoprotein in the blood circulation above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T09:17:00Z" ; oboInOwl:hasDbXref "UMLS:C0235971", "UMLS:C0476489" ; oboInOwl:hasExactSynonym "Increased levels of alpha fetoprotein", "Increased serum alpha-fetoprotein", "Serum alpha-fetoprotein increased" ; oboInOwl:hasRelatedSynonym "Alpha fetoprotein abnormal" ; oboInOwl:id "HP:0006254" ; a owl:Class ; rdfs:comment "An elevation of alpha-feto protein, which is produced by the fetal liver and the yolk sac and may be increased in the serum of pregnant women with a fetus with some types of developmental anomaly such as open neural tube defects and omphalocele." ; rdfs:label "Elevated circulating alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0045056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003809 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006256 dcterms:creator ; oboInOwl:creation_date "2008-03-28T10:14:00Z" ; oboInOwl:hasDbXref "UMLS:C4025076" ; oboInOwl:hasExactSynonym "Abnormality of hand joint mobility" ; oboInOwl:id "HP:0006256" ; a owl:Class ; rdfs:label "Abnormality of hand joint mobility" ; rdfs:subClassOf obo:HP_0001155, obo:HP_0011729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000004 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003839 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006257 dcterms:creator ; oboInOwl:creation_date "2008-03-28T02:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4025075" ; oboInOwl:hasExactSynonym "Abnormal wrist bone maturation" ; oboInOwl:id "HP:0006257" ; a owl:Class ; rdfs:label "Abnormality of carpal bone ossification" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006261 dcterms:creator ; oboInOwl:creation_date "2008-03-28T02:55:00Z" ; oboInOwl:hasAlternativeId "HP:0004266" ; oboInOwl:hasDbXref "UMLS:C4021604" ; oboInOwl:hasExactSynonym "Abnormality of phalangeal joints of the hand", "Abnormality of the small joints of the hand" ; oboInOwl:id "HP:0006261" ; a owl:Class ; rdfs:label "Abnormal phalangeal joint morphology of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007722 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006262 obo:IAO_0000115 "A small/hypoplastic or absent/aplastic 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T02:59:00Z" ; oboInOwl:hasDbXref "UMLS:C4025074" ; oboInOwl:hasExactSynonym "Absent/small little finger", "Absent/small pinkie finger", "Absent/small pinky finger", "Absent/underdeveloped little finger", "Absent/underdeveloped pinkie finger", "Absent/underdeveloped pinky finger" ; oboInOwl:id "HP:0006262" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 5th finger" ; rdfs:subClassOf obo:HP_0004207, obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006263 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T03:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4025073" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the index finger bone" ; oboInOwl:id "HP:0006263" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0004100, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006264 obo:IAO_0000115 "A small/hypoplastic or absent/aplastic 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T03:06:00Z" ; oboInOwl:hasDbXref "UMLS:C4025072" ; oboInOwl:hasExactSynonym "Absent/small index finger", "Absent/underdeveloped index finger" ; oboInOwl:id "HP:0006264" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 2nd finger" ; rdfs:subClassOf obo:HP_0004100, obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006265 obo:IAO_0000115 "Small/hypoplastic or absent/aplastic fingers." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T03:09:00Z" ; oboInOwl:hasDbXref "UMLS:C4025071" ; oboInOwl:hasExactSynonym "Absent/small fingers", "Absent/underdeveloped fingers" ; oboInOwl:id "HP:0006265" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of fingers" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0005927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006266 obo:IAO_0000115 "Reduced size of the placenta." ; oboInOwl:hasDbXref "SNOMEDCT_US:289264006", "UMLS:C0566694" ; oboInOwl:hasExactSynonym "Small placenta" ; oboInOwl:id "HP:0006266" ; a owl:Class ; rdfs:label "Small placenta" ; rdfs:subClassOf obo:HP_0012767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006267 obo:IAO_0000115 "Increased size of the placenta." ; oboInOwl:hasDbXref "SNOMEDCT_US:289263000", "UMLS:C0566693" ; oboInOwl:hasExactSynonym "Large placenta", "Placental enlargement" ; oboInOwl:id "HP:0006267" ; a owl:Class ; rdfs:label "Large placenta" ; rdfs:subClassOf obo:HP_0012767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006268 obo:IAO_0000115 "Intermittently increased size of the spleen." ; oboInOwl:hasDbXref "UMLS:C1835882" ; oboInOwl:id "HP:0006268" ; a owl:Class ; rdfs:label "Fluctuating splenomegaly" ; rdfs:subClassOf obo:HP_0001744 . obo:HP_0006270 obo:IAO_0000115 "Underdevelopment of the spleen." ; oboInOwl:hasDbXref "UMLS:C1970617" ; oboInOwl:hasExactSynonym "Underdeveloped spleen" ; oboInOwl:id "HP:0006270" ; a owl:Class ; rdfs:label "Hypoplastic spleen" ; rdfs:subClassOf obo:HP_0010451 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006273 obo:IAO_0000115 "The presence of lymphangiectasis in the pancreas." ; oboInOwl:hasDbXref "UMLS:C1856162" ; oboInOwl:id "HP:0006273" ; a owl:Class ; rdfs:label "Pancreatic lymphangiectasis" ; rdfs:subClassOf obo:HP_0012090, obo:HP_0031842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_98 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006274 obo:IAO_0000115 "Reduced number of beta cells in the pancreatic islets of Langerhans." ; oboInOwl:hasDbXref "UMLS:C1856904" ; oboInOwl:id "HP:0006274" ; a owl:Class ; rdfs:comment "The beta cells are responsible for producing insulin and amylin." ; rdfs:label "Reduced pancreatic beta cells" ; rdfs:subClassOf obo:HP_0006476 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000169 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006276 oboInOwl:hasDbXref "UMLS:C1857945" ; oboInOwl:id "HP:0006276" ; a owl:Class ; rdfs:label "Hyperechogenic pancreas" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0006277 obo:IAO_0000115 "Hyperplasia of the pancreas." ; oboInOwl:hasDbXref "UMLS:C1851733" ; oboInOwl:id "HP:0006277" ; a owl:Class ; rdfs:comment "Hyperplasia is defined in MPATH as an increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Hyperplasia is a non -neoplastic process." ; rdfs:label "Pancreatic hyperplasia" ; rdfs:subClassOf obo:HP_0012094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006278 obo:IAO_0000115 "The presence of pancreatic tissue outside the normal pancreas, in many cases along the foregut and proximal midgut." ; oboInOwl:hasDbXref "SNOMEDCT_US:264304000", "UMLS:C0994638" ; oboInOwl:hasExactSynonym "Abnormal pancreas location" ; oboInOwl:id "HP:0006278" ; a owl:Class ; rdfs:label "Ectopic pancreatic tissue" ; rdfs:subClassOf obo:HP_0012090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006279 oboInOwl:hasDbXref "UMLS:C1969875" ; oboInOwl:id "HP:0006279" ; a owl:Class ; rdfs:label "Beta-cell dysfunction" ; rdfs:subClassOf obo:HP_0006476 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000169 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006280 obo:IAO_0000115 "A chronic form of pancreatitis." ; oboInOwl:hasDbXref "MSH:D050500", "SNOMEDCT_US:233870001", "SNOMEDCT_US:234689009", "SNOMEDCT_US:235494005", "UMLS:C0149521" ; oboInOwl:hasExactSynonym "Chronic pancreas inflammation" ; oboInOwl:id "HP:0006280" ; a owl:Class ; rdfs:label "Chronic pancreatitis" ; rdfs:subClassOf obo:HP_0001733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006282 obo:IAO_0000115 "A generalized form of developmental hypoplasia of the dental enamel." ; oboInOwl:hasDbXref "UMLS:C4025070", "UMLS:C4280462" ; oboInOwl:hasExactSynonym "Generalised hypoplasia of dental enamel", "Generalised hypoplasia of tooth enamel", "Generalized hypoplasia of tooth enamel" ; oboInOwl:hasRelatedSynonym "Generalised dysplasia of tooth enamel", "Generalized dysplasia of tooth enamel" ; oboInOwl:id "HP:0006282" ; a owl:Class ; rdfs:label "Generalized hypoplasia of dental enamel" ; rdfs:subClassOf obo:HP_0006297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0006283 obo:IAO_0000115 "The presence of multiple embedded tooth germs which have failed to erupt." ; oboInOwl:hasDbXref "UMLS:C4025069" ; oboInOwl:hasExactSynonym "Failure of eruption of multiple teeth", "Multiple non-erupting teeth", "Multiple unerupted teeth" ; oboInOwl:id "HP:0006283" ; a owl:Class ; rdfs:label "Multiple unerupted teeth" ; rdfs:subClassOf obo:HP_0000706 . obo:HP_0006285 obo:IAO_0000115 "A decreased amount of enamel mineralization. Hypomineralized enamel has a brown discoloration and brittle aspect." ; oboInOwl:hasAlternativeId "HP:0006359" ; oboInOwl:hasDbXref "SNOMEDCT_US:109487003", "UMLS:C3665628", "UMLS:C4280253", "UMLS:C4280460", "UMLS:C4280461" ; oboInOwl:hasExactSynonym "Decreased enamel mineralisation", "Hypomineralization of enamel", "Mottled tooth enamel", "Poorly mineralized tooth enamel" ; oboInOwl:hasNarrowSynonym "Increased porosity of tooth enamel" ; oboInOwl:hasRelatedSynonym "Fluorosis of tooth enamel", "White spot lesions of tooth enamel" ; oboInOwl:id "HP:0006285" ; a owl:Class ; rdfs:comment "Enamel hypomineralization can be caused by genetic or environmental factors. It may occur in both deciduous and permanent dentitions, although more often in the permanent dentition. It may concern a single tooth, several teeth, or the complete dentition and may affect part or the complete surface of the tooth. Enamel hypomineralization is a qualitative defect of enamel, in which the enamel can be rough and softer. Affected teeth may be sensitive. Enamel hypomineralization can be part of molar incisor hypomineralization (hypomineralisation of systemic origin of one to four permanent first molars, frequently associated with affected incisors) and of hypomineralized second primary molars (or deciduous molar hypomineralisation, which indicates idiopathic hypomineralization of one to four second deciduous molars)." ; rdfs:label "Enamel hypomineralization" ; rdfs:subClassOf obo:HP_0000682 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070166 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006286 oboInOwl:hasDbXref "UMLS:C1863008" ; oboInOwl:hasExactSynonym "Yellow-brown discoloration of the teeth", "Yellow-brown discolored teeth", "Yellow-brown discoloured teeth", "Yellow-brown tooth shade" ; oboInOwl:id "HP:0006286" ; a owl:Class ; rdfs:label "Yellow-brown discoloration of the teeth" ; rdfs:subClassOf obo:HP_0011073 . obo:HP_0006288 obo:IAO_0000115 "Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age." ; oboInOwl:hasAlternativeId "HP:0006317" ; oboInOwl:hasDbXref "SNOMEDCT_US:16000003", "UMLS:C0266054" ; oboInOwl:hasExactSynonym "Advanced dental eruption", "Advanced tooth eruption", "Early dental eruption", "Early eruption of teeth", "Eruption, advanced", "Premature dental eruption", "Premature eruption of teeth", "Premature tooth eruption" ; oboInOwl:id "HP:0006288" ; a owl:Class ; rdfs:comment "There are established norms for the timing of eruption in both deciduous and permanent teeth [Garn and Rohmann, [1966]; Lunt and Law, [1974]; McDonald et al. [2004]]. Eruption is defined by the appearance of a tooth that has pierced the gum." ; rdfs:label "Advanced eruption of teeth" ; rdfs:subClassOf obo:HP_0006292 . obo:HP_0006289 obo:IAO_0000115 "Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor." ; oboInOwl:hasAlternativeId "HP:0006320" ; oboInOwl:hasDbXref "UMLS:C1855000", "UMLS:C4020819" ; oboInOwl:hasExactSynonym "Absent central incisor", "Failure of development of central incisor" ; oboInOwl:hasRelatedSynonym "Absent central incisors", "Missing central incisors" ; oboInOwl:id "HP:0006289" ; a owl:Class ; rdfs:label "Agenesis of central incisor" ; rdfs:subClassOf obo:HP_0006485 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018551 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006290 obo:IAO_0000115 "The presence of discolored lateral incisors." ; oboInOwl:hasBroadSynonym "Abnormality of color of front teeth", "Abnormality of color of lateral incisor", "Abnormality of colour of front teeth", "Abnormality of colour of lateral incisor", "Abnormality of shade of lateral incisor", "Discolored front teeth", "Discoloured front teeth" ; oboInOwl:hasDbXref "UMLS:C1866510", "UMLS:C4280459" ; oboInOwl:hasExactSynonym "Discoloured lateral incisors" ; oboInOwl:id "HP:0006290" ; a owl:Class ; rdfs:label "Discolored lateral incisors" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0006291 oboInOwl:hasDbXref "UMLS:C1863009" ; oboInOwl:hasExactSynonym "Severe delay of eruption of adult teeth", "Severe delay of eruption of permanent teeth", "Very late eruption of adult teeth", "Very late eruption of permanent teeth" ; oboInOwl:id "HP:0006291" ; a owl:Class ; rdfs:label "Marked delay in eruption of permanent teeth" ; rdfs:subClassOf obo:HP_0000696 . obo:HP_0006292 obo:IAO_0000115 "An abnormality of tooth eruption." ; oboInOwl:hasDbXref "SNOMEDCT_US:1086101000119107", "SNOMEDCT_US:234949000", "UMLS:C0012767", "UMLS:C1859363", "UMLS:C3874458" ; oboInOwl:hasExactSynonym "Abnormal dental eruption", "Abnormality of tooth eruption" ; oboInOwl:hasNarrowSynonym "Anomaly of dental eruption", "Anomaly of tooth eruption", "Disorder of dental eruption", "Disorder of tooth eruption" ; oboInOwl:hasRelatedSynonym "Disturbance of dental eruption", "Disturbance of tooth eruption" ; oboInOwl:id "HP:0006292" ; a owl:Class ; rdfs:comment "The average ages for eruption of the primary teeth are: 6 months: lower central incisor, 7 months: upper central incisor, 8 months: upper lateral incisor, 9 months: lower lateral incisor, 12 months first molars, 18 months, canines, 2 years, second molars." ; rdfs:label "Abnormality of dental eruption" ; rdfs:subClassOf obo:HP_0000164 . obo:HP_0006293 obo:IAO_0000115 "Agenesis of upper secondary incisor or of upper central primary incisor." ; oboInOwl:hasDbXref "UMLS:C4025068", "UMLS:C4280458" ; oboInOwl:hasExactSynonym "Failure of development of maxillary central incisor" ; oboInOwl:hasRelatedSynonym "Absence of maxillary central incisor", "Missing maxillary central incisor", "Missing upper central incisor" ; oboInOwl:id "HP:0006293" ; a owl:Class ; rdfs:label "Agenesis of maxillary central incisor" ; rdfs:subClassOf obo:HP_0006289, obo:HP_0200160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006297 obo:IAO_0000115 "Developmental hypoplasia of the dental enamel." ; oboInOwl:hasAlternativeId "HP:0000671", "HP:0001565", "HP:0003770" ; oboInOwl:hasBroadSynonym "Defective enamel matrix", "Thin dental enamel", "Thin tooth enamel" ; oboInOwl:hasDbXref "MSH:D003744", "SNOMEDCT_US:26597004", "SNOMEDCT_US:699382004", "SNOMEDCT_US:699421005", "UMLS:C0011351", "UMLS:C1851854", "UMLS:C4280456", "UMLS:C4280457" ; oboInOwl:hasExactSynonym "Dental enamel hypoplasia", "Enamel hypotrophy", "Enamel, underdeveloped", "Hypoplasia of dental enamel", "Hypoplasia of tooth enamel", "Underdeveloped teeth enamel" ; oboInOwl:hasRelatedSynonym "Dysplasia of tooth enamel", "Enamel dysplasia" ; oboInOwl:id "HP:0006297" ; a owl:Class ; rdfs:comment "Enamel hypoplasia can be caused by genetic or environmental factors. It may occur in both deciduous and permanent dentitions, although more often in the permanent dentition. Enamel hypoplasia may concern a single tooth, several teeth, or the complete dentition and may affect part or the complete surface of the tooth. Enamel hypoplasia regroups different clinical aspects: localized hypoplasia, generalized hypoplasia, enamel pits, enamel striae, and grooves defects. The term should be used to describe a quantitative defect of enamel. Enamel hypotrophy cannot be used as hypotrophy indicates loss of cells, whereas enamel is an acellular structure and thus not a tissue." ; rdfs:label "Enamel hypoplasia" ; rdfs:subClassOf obo:HP_0000682, obo:HP_0000685 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006298 obo:IAO_0000115 "Prolonged bleeding post dental extraction sufficient to require medical intervention." ; oboInOwl:hasDbXref "UMLS:C1969572" ; oboInOwl:hasExactSynonym "Prolonged bleeding after dental extraction" ; oboInOwl:id "HP:0006298" ; a owl:Class ; rdfs:label "Prolonged bleeding after dental extraction" ; rdfs:subClassOf obo:HP_0011890 . obo:HP_0006302 obo:IAO_0000115 "Dagger-shaped calcifications in the dental pulp." ; oboInOwl:hasDbXref "UMLS:C4025067" ; oboInOwl:hasExactSynonym "Dagger shaped pulp denticles", "Dagger shaped pulp stones" ; oboInOwl:id "HP:0006302" ; a owl:Class ; rdfs:label "Dagger-shaped pulp calcifications" ; rdfs:subClassOf obo:HP_0003771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001754 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006304 oboInOwl:hasDbXref "SNOMEDCT_US:196409003", "UMLS:C0399545" ; oboInOwl:hasExactSynonym "Anterior diastema of teeth", "Gap between front teeth", "Widely spaced front teeth" ; oboInOwl:hasNarrowSynonym "Diastema between front teeth", "Diastema between incisors" ; oboInOwl:id "HP:0006304" ; a owl:Class ; rdfs:label "Widely-spaced incisors" ; rdfs:subClassOf obo:HP_0000699, obo:HP_0040159 . obo:HP_0006308 oboInOwl:hasDbXref "UMLS:C1855642", "UMLS:C4280454", "UMLS:C4280455" ; oboInOwl:hasExactSynonym "Atrophy of alveolar margins", "Atrophy of alveolar processes of jaw", "Resorption of alveolar margins", "Resorption of alveolar processes of jaw", "Resorption of alveolar ridges", "Shrinking of alveolar ridges", "Shrinking of gum ridges" ; oboInOwl:hasRelatedSynonym "Alveolar bone loss", "Flattening of alveolar margin", "Flattening of alveolar processes of jaw", "Flattening of alveolar ridges", "Flattening of gum ridges" ; oboInOwl:id "HP:0006308" ; a owl:Class ; rdfs:label "Atrophy of alveolar ridges" ; rdfs:subClassOf obo:HP_0006477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006311 obo:IAO_0000115 "A generalized form of microdontia." ; oboInOwl:hasBroadSynonym "Decreased size of all teeth", "Hypotrophy of all teeth", "Tooth mass insufficiency" ; oboInOwl:hasDbXref "UMLS:C4025065" ; oboInOwl:hasExactSynonym "Decreased tooth mass", "Decreased width of all teeth", "Generalised microdontia" ; oboInOwl:id "HP:0006311" ; a owl:Class ; rdfs:label "Generalized microdontia" ; rdfs:subClassOf obo:HP_0000691 . obo:HP_0006313 obo:IAO_0000115 "Increased space between the primary teeth. Note this phenotype should be distinguished from increased space due purely to microdontia." ; oboInOwl:hasDbXref "UMLS:C4021603" ; oboInOwl:hasExactSynonym "Generalised spacing of primary teeth", "Generalized spacing of primary teeth", "Wide gaps between baby teeth", "Wide gaps between primary teeth", "Widely spaced baby teeth", "Widely spaced deciduous teeth", "Widely spaced milk teeth" ; oboInOwl:id "HP:0006313" ; a owl:Class ; rdfs:label "Widely spaced primary teeth" ; rdfs:subClassOf obo:HP_0000687, obo:HP_0006481 . obo:HP_0006315 obo:IAO_0000115 "A single maxillary central incisor positioned in the midline with morphological symmetry of the crown and bordered by lateral incisors." ; oboInOwl:hasAlternativeId "HP:0001568", "HP:0001573", "HP:0006356" ; oboInOwl:hasDbXref "MSH:C537342", "SNOMEDCT_US:707609006", "UMLS:C1840235" ; oboInOwl:hasExactSynonym "Only one upper front tooth", "Single central incisor", "Single central upper incisor", "Single maxillary central incisor", "Single median incisor", "Single median maxillary incisor", "Single midline maxillary incisor", "Single midline upper front tooth", "Solitary median maxillary central incisor", "Solitary midline maxillary central incisor" ; oboInOwl:hasNarrowSynonym "Solitary median maxillary central incisor syndrome" ; oboInOwl:id "HP:0006315" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The tooth differs from a normal central incisor in the symmetric formation of the crown. The tooth is present in both deciduous and permanent dentition. Solitary/single median maxillary central incisor syndrome indicates the presence of a single median maxillary central incisor together with other midline defects of development. A single maxillary central incisor not positioned in the midline indicates agenesis of the contralateral central incisor and A single maxillary central incisor positioned in the midline with mor- can be differentiated furthermore by the morphology of the crown. A diagnosis of a solitary median maxillary central incisor typically requires X-rays examinations." ; rdfs:label "Solitary median maxillary central incisor" ; rdfs:subClassOf obo:HP_0011064 . obo:HP_0006316 obo:IAO_0000115 "Irregular distribution of the teeth along the dental arch, i.e., and irregular spatial pattern of teeth." ; oboInOwl:hasAlternativeId "HP:0009081" ; oboInOwl:hasDbXref "UMLS:C1845878" ; oboInOwl:hasExactSynonym "Irregular dental spacing", "Irregularly spaced teeth", "Variability of dental spacing", "Variability of spacing between teeth" ; oboInOwl:id "HP:0006316" ; a owl:Class ; rdfs:label "Irregularly spaced teeth" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0006321 oboInOwl:hasDbXref "UMLS:C1848904" ; oboInOwl:hasExactSynonym "Failure of eruption of multiple adult teeth", "Failure of eruption of multiple permanent teeth", "Multiple non-erupting adult teeth", "Multiple non-erupting permanent teeth", "Multiple unerupted adult teeth", "Multiple unerupted permanent teeth" ; oboInOwl:id "HP:0006321" ; a owl:Class ; rdfs:label "Multiple non-erupting secondary teeth" ; rdfs:subClassOf obo:HP_0000696 . obo:HP_0006323 obo:IAO_0000115 "Loss of the primary (also known as deciduous) teeth before the usual age." ; oboInOwl:hasAlternativeId "HP:0006319", "HP:0006351" ; oboInOwl:hasDbXref "SNOMEDCT_US:122483006", "SNOMEDCT_US:39034005", "UMLS:C0266052" ; oboInOwl:hasExactSynonym "Early loss of baby teeth", "Early loss of deciduous teeth", "Early loss of primary teeth", "Premature deciduous tooth loss", "Premature loss of baby teeth", "Premature loss of deciduous teeth" ; oboInOwl:hasNarrowSynonym "Premature exfoliation of deciduous teeth", "Premature exfoliation of primary teeth" ; oboInOwl:id "HP:0006323" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The primary teeth are usually shed and replaced by the permanent teeth, usually by the age of six years. With premature loss of primary teeth, there is a delay between the loss of the primary teeth and the eruption of the permanent teeth." ; rdfs:label "Premature loss of primary teeth" ; rdfs:subClassOf obo:HP_0006480, obo:HP_0006481 . obo:HP_0006326 oboInOwl:hasDbXref "UMLS:C4025064" ; oboInOwl:hasExactSynonym "Failure of dental eruption due to mucopolysaccharidoses", "Failure of tooth eruption due to mucopolysaccharidoses", "Impacted teeth due to mucopolysaccharidoses", "Unerupted dentition due to mucopolysaccharidoses", "Unerupted teeth due to mucopolysaccharidoses" ; oboInOwl:id "HP:0006326" ; a owl:Class ; rdfs:label "Buried teeth encased in mucopolysaccharide" ; rdfs:subClassOf obo:HP_0000164 . obo:HP_0006329 obo:IAO_0000115 "Underdevelopment of the alveolar process (also known as alveolar bone)." ; oboInOwl:hasAlternativeId "HP:0006312" ; oboInOwl:hasDbXref "SNOMEDCT_US:708494003", "UMLS:C1848905", "UMLS:C3872671", "UMLS:C4280451", "UMLS:C4280452", "UMLS:C4280453" ; oboInOwl:hasExactSynonym "Decreased size of alveolar process of jaw", "Decreased size of alveolar ridge", "Hypoplasia of alveolar ridge", "Hypoplastic alveolar bone", "Small alveolar process of jaw", "Small alveolar ridge", "Underdevelopment of alveolar process of jaw", "Underdevelopment of alveolar ridge" ; oboInOwl:hasRelatedSynonym "Deficiency of alveolar process of jaw", "Deficiency of alveolar ridge", "Hypotrophic alveolar process of jaw", "Hypotrophic alveolar ridge" ; oboInOwl:id "HP:0006329" ; a owl:Class ; rdfs:comment "The alveolar process is a thickened ridge of bone that contains the tooth sockets on the mandible and maxilla." ; rdfs:label "Alveolar process hypoplasia" ; rdfs:subClassOf obo:HP_0006477 . obo:HP_0006330 oboInOwl:hasDbXref "UMLS:C4025063" ; oboInOwl:hasExactSynonym "Rotated upper central incisors", "Rotated upper front teeth", "Turned upper front teeth", "Twisted upper front teeth" ; oboInOwl:id "HP:0006330" ; a owl:Class ; rdfs:label "Rotated maxillary central incisors" ; rdfs:subClassOf obo:HP_0011062 . obo:HP_0006332 obo:IAO_0000115 "The presence of a supernumerary, i.e., extra, maxillary incisor, either the primary maxillary incisor or the permanent maxillary incisor." ; oboInOwl:hasDbXref "UMLS:C4025062" ; oboInOwl:hasExactSynonym "Extra upper front tooth" ; oboInOwl:id "HP:0006332" ; a owl:Class ; rdfs:label "Supernumerary maxillary incisor" ; rdfs:subClassOf obo:HP_0011064, obo:HP_0011069 . obo:HP_0006333 obo:IAO_0000115 "A type of dental misalignment with crowded central incisors, i.e., of maxillary secondary incisor, or of maxillary central primary incisor." ; oboInOwl:hasDbXref "UMLS:C4021602" ; oboInOwl:hasExactSynonym "Crowded upper front teeth", "Crowded upper incisors", "Overlapped maxillary incisors", "Overlapped upper front teeth" ; oboInOwl:id "HP:0006333" ; a owl:Class ; rdfs:label "Crowded maxillary incisors" ; rdfs:subClassOf obo:HP_0011062 . obo:HP_0006334 obo:IAO_0000115 "Developmental hypoplasia of the primary teeth." ; oboInOwl:hasAlternativeId "HP:0006318" ; oboInOwl:hasDbXref "UMLS:C1855694" ; oboInOwl:hasExactSynonym "Decreased size of baby teeth", "Decreased size of deciduous teeth", "Decreased size of milk teeth", "Decreased size of primary teeth", "Hypoplastic deciduous teeth", "Small baby teeth", "Small milk teeth", "Small primary teeth", "Underdevelopment of baby teeth", "Underdevelopment of milk teeth", "Underdevelopment of primary teeth" ; oboInOwl:id "HP:0006334" ; a owl:Class ; rdfs:label "Hypoplasia of the primary teeth" ; rdfs:subClassOf obo:HP_0000685, obo:HP_0006481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006335 obo:IAO_0000115 "Persistence of the primary teeth beyond the age by which they normally are shed and replaced by the permanent teeth." ; oboInOwl:hasAlternativeId "HP:0003772", "HP:0006299", "HP:0006305", "HP:0006341", "HP:0006354" ; oboInOwl:hasDbXref "SNOMEDCT_US:57650002", "UMLS:C0266050" ; oboInOwl:hasExactSynonym "Deciduous teeth retention", "Delayed loss of baby teeth", "Delayed loss of deciduous teeth", "Delayed loss of primary teeth", "Failure to exfoliate deciduous teeth", "Failure to exfoliate primary teeth", "Failure to lose baby teeth", "Persistence of deciduous teeth", "Persistent deciduous dentition", "Persistent primary dentition", "Persistent primary teeth", "Retained baby teeth", "Retained deciduous teeth", "Retained primary teeth" ; oboInOwl:id "HP:0006335" ; a owl:Class ; rdfs:comment "The primary teeth are usually shed and replaced by the permanent teeth, usually by the age of six years. Persistence of primary teeth may be related to agenesis of the permanent teeth. Molar primary teeth may be persistent because of the agenesis of the premolars." ; rdfs:label "Persistence of primary teeth" ; rdfs:subClassOf obo:HP_0006292, obo:HP_0006481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000082 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006336 obo:IAO_0000115 "Tooth root length more than 2 SD below mean, or subjectively apparently decreased tooth root length." ; oboInOwl:hasBroadSynonym "Underdeveloped tooth roots" ; oboInOwl:hasDbXref "UMLS:C2678330" ; oboInOwl:hasExactSynonym "Decreased length of dental roots", "Decreased length of tooth roots", "Dental root hypoplasia", "Dental root hypotrophy", "Rhizomicry", "Root dwarfism", "Short dental roots", "Short tooth roots", "Underdeveloped dental roots" ; oboInOwl:id "HP:0006336" ; a owl:Class ; rdfs:label "Short dental root" ; rdfs:subClassOf obo:HP_0040220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006337 obo:IAO_0000115 "Premature tooth eruption of the permanent dentition." ; oboInOwl:hasDbXref "UMLS:C4021601" ; oboInOwl:hasExactSynonym "Early eruption of adult teeth", "Early eruption of permanent teeth", "Precocious eruption of secondary dentition", "Precocious eruption of secondary teeth", "Premature eruption of adult teeth" ; oboInOwl:id "HP:0006337" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Premature eruption of permanent teeth" ; rdfs:subClassOf obo:HP_0006288 . obo:HP_0006338 obo:IAO_0000115 "An abnormality of the morphology of secondary premolar tooth." ; oboInOwl:hasDbXref "UMLS:C4025061" ; oboInOwl:hasExactSynonym "Malformation of lower premolar", "Malformation of mandibular bicuspid" ; oboInOwl:id "HP:0006338" ; a owl:Class ; rdfs:label "Malformation of mandibular premolar" ; rdfs:subClassOf obo:HP_0011080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006339 obo:IAO_0000115 "An abnormal conical morphology of the primary or permanent mandibular incisors." ; oboInOwl:hasDbXref "UMLS:C4020818", "UMLS:C4280449", "UMLS:C4280450" ; oboInOwl:hasExactSynonym "Cone shaped lower front tooth", "Conoid mandibular incisor", "Lower front shark tooth" ; oboInOwl:hasRelatedSynonym "Peg shaped lower front tooth", "Peg shaped mandibular incisor", "Pointed mandibular incisor", "Pointed mandibular incisors" ; oboInOwl:id "HP:0006339" ; a owl:Class ; rdfs:label "Conical mandibular incisor" ; rdfs:subClassOf obo:HP_0011065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006342 obo:IAO_0000115 "A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter" ; oboInOwl:hasBroadSynonym "Peg laterals" ; oboInOwl:hasDbXref "UMLS:C4025060" ; oboInOwl:hasExactSynonym "Peg shaped upper lateral incisors", "Peg-shaped tooth" ; oboInOwl:hasRelatedSynonym "Cone shaped upper lateral incisors", "Conical maxillary lateral incisors", "Conoid upper lateral incisors", "Pointed upper lateral incisors" ; oboInOwl:id "HP:0006342" ; a owl:Class ; rdfs:comment "A peg shape appearance of a tooth occurs in lateral incisors only. A peg-shaped tooth is a microdont tooth and may occur isolated or associated with other dental anomalies, such as hypodontia and oligodontia; this should be assessed and coded separately." ; rdfs:label "Peg-shaped maxillary lateral incisors" ; rdfs:subClassOf obo:HP_0011065 . obo:HP_0006344 obo:IAO_0000115 "An abnormality of morphology of primary molar." ; oboInOwl:hasDbXref "UMLS:C4025059" ; oboInOwl:hasExactSynonym "Abnormality of deciduous molar morphology", "Abnormality of shape of baby molar", "Abnormality of shape of primary molar" ; oboInOwl:id "HP:0006344" ; a owl:Class ; rdfs:label "Abnormality of primary molar morphology" ; rdfs:subClassOf obo:HP_0006481, obo:HP_0011070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006346 obo:IAO_0000115 "An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape." ; oboInOwl:hasDbXref "UMLS:C4025058" ; oboInOwl:hasExactSynonym "Screwdriver shaped front teeth", "Screwdriver-shaped incisors" ; oboInOwl:id "HP:0006346" ; a owl:Class ; rdfs:label "Screwdriver-shaped incisors" ; rdfs:subClassOf obo:HP_0011063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001938 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006347 obo:IAO_0000115 "Decreased size of the primary teeth." ; oboInOwl:hasBroadSynonym "Decreased size of primary tooth" ; oboInOwl:hasDbXref "UMLS:C1855694", "UMLS:C1856203" ; oboInOwl:hasExactSynonym "Decreased width of baby teeth", "Decreased width of deciduous teeth", "Decreased width of milk teeth", "Decreased width of primary tooth", "Microdontia of deciduous teeth", "Small deciduous teeth" ; oboInOwl:id "HP:0006347" ; a owl:Class ; rdfs:label "Microdontia of primary teeth" ; rdfs:subClassOf obo:HP_0000691, obo:HP_0006481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006349 obo:IAO_0000115 "A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth." ; oboInOwl:hasAlternativeId "HP:0000681", "HP:0006287" ; oboInOwl:hasDbXref "MSH:C563203", "SNOMEDCT_US:109444001", "SNOMEDCT_US:234948008", "UMLS:C0457756", "UMLS:C1290511" ; oboInOwl:hasExactSynonym "Absence of permanent teeth", "Absent permanent teeth", "Agenesis of permanent dentition", "Agenesis of secondary dentition", "Failure of development of permanent teeth", "Failure of development of secondary teeth", "Missing teeth" ; oboInOwl:id "HP:0006349" ; a owl:Class ; rdfs:label "Agenesis of permanent teeth" ; rdfs:subClassOf obo:HP_0009804, obo:HP_0011044 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006350 obo:IAO_0000115 "Mineralized substance filling the entire dental pulp space." ; oboInOwl:hasDbXref "UMLS:C4020817", "UMLS:C4025057", "UMLS:C4280448" ; oboInOwl:hasExactSynonym "Obliteration of the pulp chamber", "Pulp canal obliteration", "Reduced size of pulp chamber of tooth", "Small pulp chamber of tooth" ; oboInOwl:hasNarrowSynonym "Narrowing of pulp chamber of tooth" ; oboInOwl:hasRelatedSynonym "Crescent/chevron-shaped pulp chambers" ; oboInOwl:id "HP:0006350" ; a owl:Class ; rdfs:comment "The diagnosis pulp obliteration can be established using radiological studies. Gradual obliteration of the pulp is a physiologic process that occurs with aging. On radiographs the contours of the pulp disappear in part or totally, but histologically pulpal tissue remains present." ; rdfs:label "Pulp obliteration" ; rdfs:subClassOf obo:HP_0006479 . obo:HP_0006352 obo:IAO_0000115 "Lack of tooth eruption of the secondary dentition." ; oboInOwl:hasAlternativeId "HP:0006309" ; oboInOwl:hasBroadSynonym "Unerupted adult dentition", "Unerupted adult teeth", "Unerupted permanent dentition", "Unerupted permanent teeth" ; oboInOwl:hasDbXref "UMLS:C4025056", "UMLS:C4280447" ; oboInOwl:hasExactSynonym "Failure of eruption of adult teeth" ; oboInOwl:id "HP:0006352" ; a owl:Class ; rdfs:label "Failure of eruption of permanent teeth" ; rdfs:subClassOf obo:HP_0000706 . obo:HP_0006353 obo:IAO_0000115 "Developmental hypoplasia of the tooth germ, i.e., of the structure that forms in odontogenesis that will develop into a tooth." ; oboInOwl:hasBroadSynonym "Underdevelopment of tooth bud", "Underdevelopment of tooth germ" ; oboInOwl:hasDbXref "UMLS:C4025055" ; oboInOwl:hasExactSynonym "Decreased size of tooth bud", "Decreased size of tooth germ", "Hypotrophic tooth germ", "Small tooth bud", "Small tooth germ" ; oboInOwl:hasRelatedSynonym "Hypoplastic tooth buds" ; oboInOwl:id "HP:0006353" ; a owl:Class ; rdfs:label "Hypoplasia of the tooth germ" ; rdfs:subClassOf obo:HP_0000685 . obo:HP_0006355 obo:IAO_0000115 "Agenesis of lower secondary incisor or lower primary incisor." ; oboInOwl:hasDbXref "UMLS:C1840225", "UMLS:C4025054" ; oboInOwl:hasExactSynonym "Failure of development of mandibular central incisor" ; oboInOwl:hasRelatedSynonym "Absence of lower central incisor", "Absence of mandibular central incisor", "Missing lower central incisor", "Missing mandibular central incisor" ; oboInOwl:id "HP:0006355" ; a owl:Class ; rdfs:label "Agenesis of mandibular central incisor" ; rdfs:subClassOf obo:HP_0006289, obo:HP_0200161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006357 obo:IAO_0000115 "Premature loss of the permanent teeth." ; oboInOwl:hasDbXref "UMLS:C1969738" ; oboInOwl:hasExactSynonym "Early loss of adult teeth", "Early loss of permanent teeth", "Early loss of secondary dentition", "Premature loss of adult teeth", "Premature loss of secondary teeth" ; oboInOwl:id "HP:0006357" ; a owl:Class ; rdfs:label "Premature loss of permanent teeth" ; rdfs:subClassOf obo:HP_0006480 . obo:HP_0006358 obo:IAO_0000115 "A tooth with a crown with marked lingual or palatal marginal ridges causing scooped lingual or palatal surfaces." ; oboInOwl:hasDbXref "UMLS:C1833168" ; oboInOwl:hasExactSynonym "Shovel tooth", "Shovel-shaped upper front teeth" ; oboInOwl:id "HP:0006358" ; a owl:Class ; rdfs:label "Shovel-shaped maxillary central incisors" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0006361 oboInOwl:hasDbXref "UMLS:C1850658" ; oboInOwl:hasExactSynonym "Irregular thighbone end part" ; oboInOwl:id "HP:0006361" ; a owl:Class ; rdfs:label "Irregular femoral epiphysis" ; rdfs:subClassOf obo:HP_0006499, obo:HP_0010582 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006362 oboInOwl:hasDbXref "UMLS:C1854948" ; oboInOwl:id "HP:0006362" ; a owl:Class ; rdfs:label "Varus deformity of humeral neck" ; rdfs:subClassOf obo:HP_0003887 . obo:HP_0006366 oboInOwl:hasDbXref "UMLS:C1859524" ; oboInOwl:id "HP:0006366" ; a owl:Class ; rdfs:label "Adductor longus contractures" ; rdfs:subClassOf obo:HP_0005750 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000303 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006367 obo:IAO_0000115 "An crumpled radiographic appearance of the long bones, as if the long bone had been crushed together producing irregularities. This feature is the result of multiple fractures and repeated rounds of ineffective healing, as can be seen for instance in severe forms of osteogenesis imperfecta." ; oboInOwl:hasDbXref "UMLS:C1970497" ; oboInOwl:hasExactSynonym "Crumpled long bones" ; oboInOwl:id "HP:0006367" ; a owl:Class ; rdfs:label "Crumpled long bones" ; rdfs:subClassOf obo:HP_0011314 . obo:HP_0006368 oboInOwl:hasDbXref "UMLS:C1849327" ; oboInOwl:id "HP:0006368" ; a owl:Class ; rdfs:label "Forearm reduction defects" ; rdfs:subClassOf obo:HP_0002973 . obo:HP_0006369 obo:IAO_0000115 "An alteration of the normally relatively smooth margins of the kneecap in radiographic images leading to an irregular contour." ; oboInOwl:hasAlternativeId "HP:0006458" ; oboInOwl:hasDbXref "UMLS:C1836870" ; oboInOwl:hasExactSynonym "Irregular patellar contour", "Irregular patellar margins" ; oboInOwl:id "HP:0006369" ; a owl:Class ; rdfs:label "Irregular patellae" ; rdfs:subClassOf obo:HP_0003045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006370 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the distal epiphysis of the ulna." ; oboInOwl:hasDbXref "UMLS:C4021600" ; oboInOwl:hasExactSynonym "Distal ulnar epiphyseal calcifications" ; oboInOwl:id "HP:0006370" ; a owl:Class ; rdfs:label "Distal ulnar epiphyseal stippling" ; rdfs:subClassOf obo:HP_0010600, obo:HP_0010655, obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006371 obo:IAO_0000115 "Increased width of the diaphysis of long bones." ; oboInOwl:hasDbXref "UMLS:C4025053" ; oboInOwl:hasExactSynonym "Broad shaft of long bone", "Wide shaft of long bone" ; oboInOwl:id "HP:0006371" ; a owl:Class ; rdfs:label "Broad long bone diaphyses" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002359 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006375 obo:IAO_0000115 "The femur is shortened and displays flaring (widening) of the metaphyses." ; oboInOwl:hasDbXref "UMLS:C4025052" ; oboInOwl:hasExactSynonym "Dumbbell-shaped thighbone" ; oboInOwl:id "HP:0006375" ; a owl:Class ; rdfs:label "Dumbbell-shaped femur" ; rdfs:subClassOf obo:HP_0000947, obo:HP_0002823 . obo:HP_0006376 oboInOwl:hasDbXref "UMLS:C1856922" ; oboInOwl:id "HP:0006376" ; a owl:Class ; rdfs:label "Limited elbow flexion" ; rdfs:subClassOf obo:HP_0002996 . obo:HP_0006378 oboInOwl:hasDbXref "UMLS:C4025051" ; oboInOwl:id "HP:0006378" ; a owl:Class ; rdfs:label "Osteolysis of patellae" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0009139 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006379 oboInOwl:hasDbXref "UMLS:C1856029" ; oboInOwl:hasExactSynonym "Proximal tibial hypopolasia" ; oboInOwl:id "HP:0006379" ; a owl:Class ; rdfs:comment "Removed logical definition that used anonymous class. Requested new term from UBERON: 'proximal tibia'" ; rdfs:label "Proximal tibial hypoplasia" ; rdfs:subClassOf obo:HP_0005736 . obo:HP_0006380 obo:IAO_0000115 "A type of knee joint contracture in which the knee is in a fixed bent (flexed) configuration such that it cannot be straightened actively or passively." ; oboInOwl:hasAlternativeId "HP:0002978" ; oboInOwl:hasBroadSynonym "Inability to straighten knee" ; oboInOwl:hasDbXref "SNOMEDCT_US:202289003", "UMLS:C0409355" ; oboInOwl:hasExactSynonym "Flexion contracture of knees", "Flexion contractures at both knees", "Flexion contractures of knees", "Flexion deformity of the knee", "Knee flexion contractures", "Knee flexion deformity" ; oboInOwl:id "HP:0006380" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Knee flexion contracture" ; rdfs:subClassOf obo:HP_0005750, obo:HP_0034671 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006381 obo:IAO_0000115 "Absent or nearly absent fibula. (Does not include aplastic)" ; oboInOwl:hasAlternativeId "HP:0004986" ; oboInOwl:hasDbXref "UMLS:C1844706" ; oboInOwl:hasExactSynonym "Rudimentary to absent fibulae", "Small to absent calf bone", "Small to absent fibula" ; oboInOwl:id "HP:0006381" ; a owl:Class ; rdfs:label "Rudimentary fibula" ; rdfs:subClassOf obo:HP_0003038 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006383 obo:IAO_0000115 "Progressive bending or abnormal curvature of a long bone." ; oboInOwl:hasDbXref "UMLS:C1857137" ; oboInOwl:id "HP:0006383" ; a owl:Class ; rdfs:label "Progressive bowing of long bones" ; rdfs:subClassOf obo:HP_0006487 . obo:HP_0006384 obo:IAO_0000115 "An abnormal conformation of the femur that becomes gradually enlarged towards the distal end. This feature affects the distal femoral metaphysis and epiphysis." ; oboInOwl:hasAlternativeId "HP:0006447" ; oboInOwl:hasDbXref "UMLS:C1857505" ; oboInOwl:hasExactSynonym "Club-shaped distal femora", "Club-shaped outermost end of thighbone" ; oboInOwl:id "HP:0006384" ; a owl:Class ; rdfs:comment """previous def: 'has part' some (clavate and ('inheres in' some 'Distal end of femur (adult human)') and ('has modifier' some abnormal))""" ; rdfs:label "Club-shaped distal femur" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0006385 obo:IAO_0000115 "Shortening of the legs related to developmental hypoplasia of the bones of the leg." ; oboInOwl:hasAlternativeId "HP:0003054" ; oboInOwl:hasDbXref "SNOMEDCT_US:249786007", "UMLS:C0426901" ; oboInOwl:hasExactSynonym "Short legs", "Short lower limbs" ; oboInOwl:id "HP:0006385" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short lower limbs" ; rdfs:subClassOf obo:HP_0009816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006386 obo:IAO_0000115 "Underdevelopment of the distal epiphysis of the radius." ; oboInOwl:hasDbXref "UMLS:C1969286" ; oboInOwl:id "HP:0006386" ; a owl:Class ; rdfs:label "Hypoplastic distal radial epiphyses" ; rdfs:subClassOf obo:HP_0010597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006387 obo:IAO_0000115 "Increased width of the distal part of the shaft (metaphysis) of the femur." ; oboInOwl:hasDbXref "UMLS:C1849309" ; oboInOwl:hasExactSynonym "Broad outermost wide portion of thighbone", "Wide distal metaphysis of femur" ; oboInOwl:id "HP:0006387" ; a owl:Class ; rdfs:label "Wide distal femoral metaphysis" ; rdfs:subClassOf obo:HP_0030299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006389 obo:IAO_0000115 "Reduced ability to flex (bend) the knee joint." ; oboInOwl:hasDbXref "UMLS:C1839512" ; oboInOwl:id "HP:0006389" ; a owl:Class ; rdfs:label "Limited knee flexion" ; rdfs:subClassOf obo:HP_0010501 . obo:HP_0006390 obo:IAO_0000115 "An abnormal anterior bending or curvature of the tibia." ; oboInOwl:hasDbXref "UMLS:C1861937" ; oboInOwl:hasExactSynonym "Anterior bowing of tibia" ; oboInOwl:id "HP:0006390" ; a owl:Class ; rdfs:label "Anterior tibial bowing" ; rdfs:subClassOf obo:HP_0002982 . obo:HP_0006391 obo:IAO_0000115 "Overconstriction, or narrowness of the diaphysis and metaphysis of long bones." ; oboInOwl:hasDbXref "UMLS:C1848769" ; oboInOwl:id "HP:0006391" ; a owl:Class ; rdfs:label "Overtubulated long bones" ; rdfs:subClassOf obo:HP_0011314 . obo:HP_0006392 obo:IAO_0000115 "An abnormal increase in the bone density of the long bones." ; oboInOwl:hasDbXref "UMLS:C1849307" ; oboInOwl:hasExactSynonym "Increased density of long bones" ; oboInOwl:id "HP:0006392" ; a owl:Class ; rdfs:label "Increased density of long bones" ; rdfs:subClassOf obo:HP_0011001, obo:HP_0011314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006394 obo:IAO_0000115 "A limitation of the ability to place the forearm in a position such that the palm faces anteriorly (supination) and to place the forearm in a position such that the palm faces posteriorly (pronation)." ; oboInOwl:hasDbXref "UMLS:C1861331" ; oboInOwl:hasExactSynonym "Limited pronation/supination of forearm" ; oboInOwl:id "HP:0006394" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limited pronation/supination of forearm" ; rdfs:subClassOf obo:HP_0002996 . obo:HP_0006397 oboInOwl:hasDbXref "UMLS:C1860156" ; oboInOwl:id "HP:0006397" ; a owl:Class ; rdfs:label "Lateral displacement of patellae" ; rdfs:subClassOf obo:HP_0003045 . obo:HP_0006398 obo:IAO_0000115 "An abnormal flattening of the distal epiphysis of femur." ; oboInOwl:hasDbXref "UMLS:C4021599" ; oboInOwl:hasExactSynonym "Flat end part of outermost thighbone", "Flattened distal femoral epiphyses" ; oboInOwl:id "HP:0006398" ; a owl:Class ; rdfs:label "Flat distal femoral epiphysis" ; rdfs:subClassOf obo:HP_0010590, obo:HP_0030289 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004406 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006400 oboInOwl:hasDbXref "UMLS:C1859462" ; oboInOwl:hasExactSynonym "Absent knee end part" ; oboInOwl:id "HP:0006400" ; a owl:Class ; rdfs:label "Absent knee epiphyses" ; rdfs:subClassOf obo:HP_0010577, obo:HP_0034669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006402 oboInOwl:hasDbXref "UMLS:C1840307" ; oboInOwl:hasExactSynonym "Short outer part of limbs" ; oboInOwl:id "HP:0006402" ; a owl:Class ; rdfs:label "Distal shortening of limbs" ; rdfs:subClassOf obo:HP_0009826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002471 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006406 obo:IAO_0000115 "An abnormal conformation of the femur that becomes gradually enlarged towards the proximal end. This feature affects the proximal femoral metaphysis and epiphysis." ; oboInOwl:hasDbXref "UMLS:C1968611" ; oboInOwl:hasExactSynonym "Club-shaped innermost end of thighbone" ; oboInOwl:id "HP:0006406" ; a owl:Class ; rdfs:comment """previous def: 'has part' some (clavate and ('inheres in' some 'Proximal end of femur (adult human)') and ('has modifier' some abnormal))""" ; rdfs:label "Club-shaped proximal femur" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0006407 obo:IAO_0000115 "Anomaly of the contour of the Distal epiphysis of femur such that its normally smooth appearance is irregular." ; oboInOwl:hasDbXref "UMLS:C4025050" ; oboInOwl:hasExactSynonym "Irregular outermost thighbone end part" ; oboInOwl:id "HP:0006407" ; a owl:Class ; rdfs:label "Irregular distal femoral epiphysis" ; rdfs:subClassOf obo:HP_0006361, obo:HP_0010590 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004406 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006408 oboInOwl:hasDbXref "UMLS:C4025049" ; oboInOwl:hasExactSynonym "Tapering of outermost end of thighbone" ; oboInOwl:id "HP:0006408" ; a owl:Class ; rdfs:label "Distal tapering femur" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0006409 obo:IAO_0000115 "Progressive bending or abnormal curvature of the leg." ; oboInOwl:hasDbXref "UMLS:C1855191" ; oboInOwl:id "HP:0006409" ; a owl:Class ; rdfs:label "Progressive leg bowing" ; rdfs:subClassOf obo:HP_0006383 . obo:HP_0006413 oboInOwl:hasDbXref "UMLS:C2678328" ; oboInOwl:hasExactSynonym "Broad wide portion of shankbone", "Broad wide portion of shinbone" ; oboInOwl:id "HP:0006413" ; a owl:Class ; rdfs:label "Broad tibial metaphyses" ; rdfs:subClassOf obo:HP_0006491 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013750 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006414 obo:IAO_0000115 "A bending or abnormal curvature of the distal portion of the tibia." ; oboInOwl:hasDbXref "UMLS:C4021598" ; oboInOwl:hasExactSynonym "Bowing of the distal tibia", "Tibial bowing at ankle" ; oboInOwl:id "HP:0006414" ; a owl:Class ; rdfs:label "Distal tibial bowing" ; rdfs:subClassOf obo:HP_0002982, obo:HP_0034673 . obo:HP_0006415 obo:IAO_0000115 "Increased density of the compact bone of long bone." ; oboInOwl:hasDbXref "UMLS:C1849276" ; oboInOwl:id "HP:0006415" ; a owl:Class ; rdfs:comment "Note that compact bone and cortical bone are synonymous." ; rdfs:label "Cortically dense long tubular bones" ; rdfs:subClassOf obo:HP_0000935 . obo:HP_0006417 oboInOwl:hasDbXref "UMLS:C1864854" ; oboInOwl:hasExactSynonym "Broad wide portion of thigh bone" ; oboInOwl:id "HP:0006417" ; a owl:Class ; rdfs:label "Broad femoral metaphyses" ; rdfs:subClassOf obo:HP_0006489 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006420 obo:IAO_0000115 "The presence of asymmetric developmental dysplasia of the radius." ; oboInOwl:hasDbXref "UMLS:C1969396" ; oboInOwl:id "HP:0006420" ; a owl:Class ; rdfs:label "Asymmetric radial dysplasia" ; rdfs:subClassOf obo:HP_0006433 . obo:HP_0006423 oboInOwl:hasDbXref "UMLS:C1846160" ; oboInOwl:id "HP:0006423" ; a owl:Class ; rdfs:label "Peg-like central prominence of distal tibial metaphyses" ; rdfs:subClassOf obo:HP_0006491 . obo:HP_0006424 obo:IAO_0000115 "Increased length of the radius." ; oboInOwl:hasDbXref "UMLS:C4025048" ; oboInOwl:id "HP:0006424" ; a owl:Class ; rdfs:label "Elongated radius" ; rdfs:subClassOf obo:HP_0002818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006426 oboInOwl:hasDbXref "UMLS:C1968943" ; oboInOwl:id "HP:0006426" ; a owl:Class ; rdfs:label "Rudimentary to absent tibiae" ; rdfs:subClassOf obo:HP_0005772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006429 obo:IAO_0000115 "An abnormally wide femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." ; oboInOwl:hasAlternativeId "HP:0003369", "HP:0003372", "HP:0008781", "HP:0008782", "HP:0008836" ; oboInOwl:hasDbXref "UMLS:C1849016" ; oboInOwl:hasExactSynonym "Broadening of femoral neck", "Wide femoral neck", "Wide neck of thigh bone", "Widened femoral necks" ; oboInOwl:id "HP:0006429" ; a owl:Class ; rdfs:label "Broad femoral neck" ; rdfs:subClassOf obo:HP_0003367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006431 obo:IAO_0000115 "An anomaly of the metaphysis of the proximal femur (close to the hip)." ; oboInOwl:hasDbXref "UMLS:C4025047" ; oboInOwl:hasExactSynonym "Abnormal wide portion of innermost thighbone" ; oboInOwl:id "HP:0006431" ; a owl:Class ; rdfs:label "Proximal femoral metaphyseal abnormality" ; rdfs:subClassOf obo:HP_0006489 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006432 oboInOwl:hasDbXref "UMLS:C1843983" ; oboInOwl:id "HP:0006432" ; a owl:Class ; rdfs:label "Trapezoidal distal femoral condyles" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0006433 obo:IAO_0000115 "Radial dysplasia, also known as radial longitudinal deficiency, includes radial clubhand and is a disfiguring, and potentially disabling, congenital limb anomaly. The entire upper limb may be involved, although the defect is most evident in the forearm and hand. Affected children suffer a variable degree of hypoplasia or absence of the preaxial skeleton and soft tissues, in particular the thumb, radius, and dorsoradial soft tissues. The hand is usually radially deviated and subluxated off the distal aspect of the ulna, the ulna may be shortened and have a bow-shaped deformity, and there is no true wrist (radiocarpal) joint in Bayne2 type-III and IV radial dysplasia." ; oboInOwl:hasDbXref "UMLS:C4025046" ; oboInOwl:hasExactSynonym "Dysplastic radii", "Radial longitudinal deficiency" ; oboInOwl:id "HP:0006433" ; a owl:Class ; rdfs:label "Radial dysplasia" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006434 obo:IAO_0000115 "Proximal radial shortening owing to a congenital defect of development." ; oboInOwl:hasAlternativeId "HP:0006365" ; oboInOwl:hasDbXref "UMLS:C1859477" ; oboInOwl:hasExactSynonym "Proximal radial shortening" ; oboInOwl:id "HP:0006434" ; a owl:Class ; rdfs:label "Hypoplasia of proximal radius" ; rdfs:subClassOf obo:HP_0002984 . obo:HP_0006436 obo:IAO_0100001 "HP:0005736" ; a owl:Class ; rdfs:label "obsolete Shortening of the tibia" ; owl:deprecated true . obo:HP_0006437 oboInOwl:hasDbXref "UMLS:C1834392" ; oboInOwl:id "HP:0006437" ; a owl:Class ; rdfs:label "Disproportionate prominence of the femoral medial condyle" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0006438 obo:IAO_0000115 "An abnormal enlargement of the distal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1843105" ; oboInOwl:hasExactSynonym "Enlargement of the outermost thighbone end part", "Large distal femoral epiphyses" ; oboInOwl:id "HP:0006438" ; a owl:Class ; rdfs:label "Enlargement of the distal femoral epiphysis" ; rdfs:subClassOf obo:HP_0010590 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004406 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006439 oboInOwl:hasAlternativeId "HP:0003972" ; oboInOwl:hasDbXref "UMLS:C2673394" ; oboInOwl:hasExactSynonym "Dislocated radioulnar joints" ; oboInOwl:id "HP:0006439" ; a owl:Class ; rdfs:label "Radioulnar dislocation" ; rdfs:subClassOf obo:HP_0003059 . obo:HP_0006440 oboInOwl:hasDbXref "UMLS:C1844516" ; oboInOwl:hasExactSynonym "Increased density of shaft of long bone" ; oboInOwl:id "HP:0006440" ; a owl:Class ; rdfs:label "Increased density of long bone diaphyses" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0006392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006441 oboInOwl:hasDbXref "UMLS:C1833878" ; oboInOwl:id "HP:0006441" ; a owl:Class ; rdfs:label "Lateral humeral condyle aplasia" ; rdfs:subClassOf obo:HP_0031095 . obo:HP_0006442 obo:IAO_0000115 "Underdevelopment or shortening of the end of the fibula (calf bone) nearest the knee." ; oboInOwl:hasDbXref "UMLS:C1859478" ; oboInOwl:hasExactSynonym "Small innermost upper end of calf bone", "Underdeveloped innermost upper end of calf bone" ; oboInOwl:id "HP:0006442" ; a owl:Class ; rdfs:label "Hypoplasia of proximal fibula" ; rdfs:subClassOf obo:HP_0003038 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006443 obo:IAO_0000115 "Absence of the patella." ; oboInOwl:hasAlternativeId "HP:0003046", "HP:0006475" ; oboInOwl:hasDbXref "UMLS:C1868578" ; oboInOwl:hasExactSynonym "Absent kneecap", "Absent patella", "Absent patellae", "Absent patellas", "Aplastic patellae" ; oboInOwl:id "HP:0006443" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Patellar aplasia" ; rdfs:subClassOf obo:HP_0006498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006446 oboInOwl:hasDbXref "UMLS:C1849580" ; oboInOwl:id "HP:0006446" ; a owl:Class ; rdfs:label "Dysplastic patella" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006449 oboInOwl:hasDbXref "UMLS:C1850145" ; oboInOwl:id "HP:0006449" ; a owl:Class ; rdfs:label "Distal radial epiphyseal osteolysis" ; rdfs:subClassOf obo:HP_0010597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004407 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006450 oboInOwl:hasDbXref "UMLS:C1857193" ; oboInOwl:id "HP:0006450" ; a owl:Class ; rdfs:label "Multicentric ossification of proximal femoral epiphyses" ; rdfs:subClassOf obo:HP_0009107, obo:HP_0010574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006453 obo:IAO_0000115 "A developmental anomaly with lateral displacement of the femoral head." ; oboInOwl:hasDbXref "UMLS:C1855758" ; oboInOwl:hasExactSynonym "Laterally displaced femoral heads" ; oboInOwl:id "HP:0006453" ; a owl:Class ; rdfs:label "Lateral displacement of the femoral head" ; rdfs:subClassOf obo:HP_0003368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001923 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006454 obo:IAO_0000115 "Formation of bone in the patella later than normal." ; oboInOwl:hasDbXref "UMLS:C4021597", "UMLS:C4280446" ; oboInOwl:hasExactSynonym "Delayed patellae ossification" ; oboInOwl:hasRelatedSynonym "Delayed bone maturation of the knee cap" ; oboInOwl:id "HP:0006454" ; a owl:Class ; rdfs:comment "The patella initially ossifies at between three and five years, commencing as multiple foci that rapidly coalesce. As the patellar ossification center enlarges the expanding margins may be irregular and associated with accessory ossification centers. These are most common superolaterally and may lead to the development of a bipartite patella. The bipartite patella has cartilaginous continuity despite the appearance of osseous discontinuity. The patella expands to all cartilaginous contours during late adolescence when the epiphyseal ossification centers around the knee are also in the final stages of maturation. The only cartilage not replaced is that occupying the superior two-thirds of the articular surface (the lower one-third is covered by the fat pad). The subchondral plate does not assume the actual articular contours until the late stages of osseous maturation (after ten to twelve years). Accordingly, typical measurements such as medial and lateral angulation cannot be accurately done prior to the final stages of patellar ossification expansion and maturation (PMID:6729496)." ; rdfs:label "Delayed patellar ossification" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006456 obo:IAO_0000115 "Anomaly of the contour of the proximal epiphysis of the tibia such that its normally smooth appearance is irregular." ; oboInOwl:hasDbXref "UMLS:C4025045" ; oboInOwl:hasExactSynonym "Irregular innermost shankbone end part", "Irregular innermost shinbone end part" ; oboInOwl:id "HP:0006456" ; a owl:Class ; rdfs:label "Irregular proximal tibial epiphyses" ; rdfs:subClassOf obo:HP_0010582, obo:HP_0010591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008772 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006459 obo:IAO_0000115 "Partial dislocation of the ulna in the dorsal direction." ; oboInOwl:hasDbXref "UMLS:C1851988" ; oboInOwl:id "HP:0006459" ; a owl:Class ; rdfs:label "Dorsal subluxation of ulna" ; rdfs:subClassOf obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001919 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006460 oboInOwl:hasDbXref "UMLS:C1850854" ; oboInOwl:id "HP:0006460" ; a owl:Class ; rdfs:label "Increased laxity of ankles" ; rdfs:subClassOf obo:HP_0034674 . obo:HP_0006461 obo:IAO_0000115 "Slipped capital femoral epiphysis is defined as a posterior and inferior slippage of the proximal epiphysis of the femur onto the metaphysis (femoral neck), occurring through the physeal plate during the early adolescent growth spurt." ; oboInOwl:hasAlternativeId "HP:0003000" ; oboInOwl:hasDbXref "MSH:D060048", "UMLS:C0149887" ; oboInOwl:hasExactSynonym "Slipped capital femoral epiphyses", "Slipped capital femoral epiphysis", "Slipped end part of innermost thighbone" ; oboInOwl:id "HP:0006461" ; a owl:Class ; rdfs:label "Proximal femoral epiphysiolysis" ; rdfs:subClassOf obo:HP_0010574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001505 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006462 obo:IAO_0000115 "A generalized decrease in bone mineral density." ; oboInOwl:hasDbXref "UMLS:C1833326" ; oboInOwl:hasExactSynonym "Generalised bone demineralization" ; oboInOwl:id "HP:0006462" ; a owl:Class ; rdfs:comment "The terms Osteopenia or Osteoporosis should be prefered to this term, which may be obsoleted in the future." ; rdfs:label "Generalized bone demineralization" ; rdfs:subClassOf obo:HP_0004349 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001790 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0006463 oboInOwl:hasDbXref "UMLS:C1833323" ; oboInOwl:id "HP:0006463" ; a owl:Class ; rdfs:label "Rickets of the lower limbs" ; rdfs:subClassOf obo:HP_0002748, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002748 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006465 obo:IAO_0000115 "Thickening of the periosteum of long bone." ; oboInOwl:hasDbXref "UMLS:C1834345" ; oboInOwl:id "HP:0006465" ; a owl:Class ; rdfs:label "Periosteal thickening of long tubular bones" ; rdfs:subClassOf obo:HP_0011314, obo:HP_0030313 . obo:HP_0006466 oboInOwl:hasAlternativeId "HP:0004985", "HP:0006403" ; oboInOwl:hasDbXref "UMLS:C1837407" ; oboInOwl:id "HP:0006466" ; a owl:Class ; rdfs:label "Ankle flexion contracture" ; rdfs:subClassOf obo:HP_0005750, obo:HP_0034677 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006467 obo:IAO_0000115 "A limitation of the range of movement of the shoulder joint." ; oboInOwl:hasDbXref "UMLS:C1851313" ; oboInOwl:hasExactSynonym "Limited shoulder movement" ; oboInOwl:id "HP:0006467" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limited shoulder movement" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0033129 . obo:HP_0006470 obo:IAO_0000115 "Decreased width of the diaphysis of long bones." ; oboInOwl:hasDbXref "UMLS:C1859449" ; oboInOwl:hasExactSynonym "Thin diaphyses of long bones", "Thin shaft of long bone" ; oboInOwl:id "HP:0006470" ; a owl:Class ; rdfs:label "Thin long bone diaphyses" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006471 oboInOwl:hasDbXref "UMLS:C4025044" ; oboInOwl:id "HP:0006471" ; a owl:Class ; rdfs:label "Fixed elbow flexion" ; rdfs:subClassOf obo:HP_0006376 . obo:HP_0006473 obo:IAO_0000115 "An abnormal anterior curvature of a long bone." ; oboInOwl:hasDbXref "UMLS:C1850644" ; oboInOwl:id "HP:0006473" ; a owl:Class ; rdfs:label "Anterior bowing of long bones" ; rdfs:subClassOf obo:HP_0006487 . obo:HP_0006476 obo:IAO_0000115 "An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T04:41:00Z" ; oboInOwl:hasAlternativeId "HP:0100567" ; oboInOwl:hasDbXref "UMLS:C4025043" ; oboInOwl:id "HP:0006476" ; a owl:Class ; rdfs:label "Abnormality of the pancreatic islet cells" ; rdfs:subClassOf obo:HP_0012093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005623 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000006 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006477 obo:IAO_0000115 "Any abnormality of the alveolar ridges (on the upper or lower jaws). The alveolar ridges contain the sockets (alveoli) of the teeth." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T04:44:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:235013007", "UMLS:C0341007", "UMLS:C4280445" ; oboInOwl:hasExactSynonym "Abnormality of alveolar margin", "Abnormality of dentoalveolar ridges", "Abnormality of gum ridge", "Defect in alveolar ridge" ; oboInOwl:hasRelatedSynonym "Abnormality of alveolar processes of jaw" ; oboInOwl:id "HP:0006477" ; a owl:Class ; rdfs:label "Abnormality of the alveolar ridges" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006479 obo:IAO_0000115 "An abnormality of the dental pulp." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T04:46:00Z" ; oboInOwl:hasDbXref "UMLS:C4025042" ; oboInOwl:hasExactSynonym "Abnormality of the dental pulp", "Abnormality of tooth pulp" ; oboInOwl:hasRelatedSynonym "Endodontic abnormality" ; oboInOwl:id "HP:0006479" ; a owl:Class ; rdfs:label "Abnormal dental pulp morphology" ; rdfs:subClassOf obo:HP_0011061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001754 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006480 obo:IAO_0000115 "Exfoliation of a tooth more than 2 SD earlier than the normal age for the deciduous teeth and not related to traume or neglect. Exfoliation of a permanent tooth is per se abnormal." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:03:00Z" ; oboInOwl:hasAlternativeId "HP:0000701", "HP:0001564", "HP:0006343" ; oboInOwl:hasDbXref "SNOMEDCT_US:234974002", "SNOMEDCT_US:42756003", "UMLS:C0232513", "UMLS:C0399385" ; oboInOwl:hasExactSynonym "Early tooth loss", "Loss of teeth", "Premature teeth loss", "Premature tooth loss" ; oboInOwl:hasNarrowSynonym "Premature exfoliation of teeth" ; oboInOwl:id "HP:0006480" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Premature loss of teeth" ; rdfs:subClassOf obo:HP_0000164 . obo:HP_0006481 obo:IAO_0000115 "Any abnormality of the primary tooth." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:40:00Z" ; oboInOwl:hasDbXref "UMLS:C4021596" ; oboInOwl:hasExactSynonym "Abnormality of baby teeth", "Abnormality of deciduous teeth", "Abnormality of milk teeth" ; oboInOwl:id "HP:0006481" ; a owl:Class ; rdfs:comment "Primary teeth are also called temporary teeth or deciduous teeth." ; rdfs:label "Abnormality of primary teeth" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006482 obo:IAO_0000115 "An abnormality of the morphology of the tooth." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:41:00Z" ; oboInOwl:hasAlternativeId "HP:0000697" ; oboInOwl:hasDbXref "MSH:D014071", "SNOMEDCT_US:422775003", "UMLS:C0040427", "UMLS:C0262444" ; oboInOwl:hasExactSynonym "Abnormality of dental shape", "Abnormality of shape of tooth", "Abnormally shaped teeth", "Deformity of teeth", "Dental deformity", "Dental malformations", "Malformation of teeth", "Malformed teeth", "Misshapen teeth", "Misshapened teeth" ; oboInOwl:id "HP:0006482" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of dental morphology" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006483 obo:IAO_0000115 "The presence of an altered number of of teeth." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:44:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:335443002", "UMLS:C1290508" ; oboInOwl:hasExactSynonym "Abnormal complement of teeth", "Abnormal number of teeth", "Abnormal tooth count" ; oboInOwl:id "HP:0006483" ; a owl:Class ; rdfs:comment "Humans usually have 20 primary teeth (also called deciduous teeth) and 32 permanent teeth. This term comprises anomalies with too many or too few teeth." ; rdfs:label "Abnormal number of teeth" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006485 obo:IAO_0000115 "Agenesis of incisor." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:49:00Z" ; oboInOwl:hasDbXref "UMLS:C4020815", "UMLS:C4020816", "UMLS:C4083290" ; oboInOwl:hasExactSynonym "Failure of development of incisor" ; oboInOwl:hasRelatedSynonym "Absence of front tooth", "Absence of incisors", "Missing front tooth", "Missing incisors" ; oboInOwl:id "HP:0006485" ; a owl:Class ; rdfs:comment "Failure of one or more incisors to develop." ; rdfs:label "Agenesis of incisor" ; rdfs:subClassOf obo:HP_0001592, obo:HP_0011064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006486 obo:IAO_0000115 "An abnormality of the dental root." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4025041" ; oboInOwl:hasExactSynonym "Abnormality of the dental root", "Abnormality of tooth root", "Dental root anomaly" ; oboInOwl:id "HP:0006486" ; a owl:Class ; rdfs:label "Abnormal dental root morphology" ; rdfs:subClassOf obo:HP_0006482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006487 obo:IAO_0000115 "A bending or abnormal curvature of a long bone." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:56:00Z" ; oboInOwl:hasAlternativeId "HP:0002976", "HP:0005087", "HP:0005908", "HP:0006404", "HP:0006451", "HP:0006452" ; oboInOwl:hasDbXref "UMLS:C1855340" ; oboInOwl:hasExactSynonym "Bowed long bones", "Bowing of long bones", "Bowing of the long bones", "Camptomelia", "Diaphyseal bowing", "Diaphyseal bowing of long bones" ; oboInOwl:id "HP:0006487" ; a owl:Class ; rdfs:comment "Curvatures of a long bone such as femur, tibia, or fibula." ; rdfs:label "Bowing of the long bones" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006488 obo:IAO_0000115 "A bending or abnormal curvature affecting a long bone of the arm." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T05:57:00Z" ; oboInOwl:hasDbXref "UMLS:C0426863" ; oboInOwl:hasExactSynonym "Bending of the arm", "Bowing of the arm" ; oboInOwl:id "HP:0006488" ; a owl:Class ; rdfs:label "Bowing of the arm" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0006487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008962 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006489 obo:IAO_0000115 "An anomaly of the femoral metaphysis." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:02:00Z" ; oboInOwl:hasBroadSynonym "Abnormality of the wide portion of the femoral bone" ; oboInOwl:hasDbXref "UMLS:C4025040", "UMLS:C4280444" ; oboInOwl:hasExactSynonym "Abnormality of the femoral metaphysis" ; oboInOwl:id "HP:0006489" ; a owl:Class ; rdfs:label "Abnormal femoral metaphysis morphology" ; rdfs:subClassOf obo:HP_0002823, obo:HP_0006490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006490 dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:02:00Z" ; oboInOwl:hasDbXref "UMLS:C4025039" ; oboInOwl:hasExactSynonym "Abnormality of lower-limb metaphyses", "Abnormality of the wide portion of the lower-limb bone" ; oboInOwl:id "HP:0006490" ; a owl:Class ; rdfs:label "Abnormal lower-limb metaphysis morphology" ; rdfs:subClassOf obo:HP_0000944, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006491 dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:03:00Z" ; oboInOwl:hasBroadSynonym "Abnormality of the wide portion of shankbone", "Abnormality of the wide portion of shinbone" ; oboInOwl:hasDbXref "UMLS:C4025038" ; oboInOwl:hasExactSynonym "Abnormality of the tibial metaphysis" ; oboInOwl:id "HP:0006491" ; a owl:Class ; rdfs:label "Abnormal tibial metaphysis morphology" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0006490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013750 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006492 obo:IAO_0000115 "Absence or underdevelopment of the fibula." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:03:00Z" ; oboInOwl:hasAlternativeId "HP:0005672", "HP:0006421" ; oboInOwl:hasDbXref "UMLS:C1856732" ; oboInOwl:hasExactSynonym "Absent/small calf bone", "Absent/underdeveloped calf bone", "Fibular aplasia/hypoplasia", "Hypoplastic/aplastic fibulae" ; oboInOwl:id "HP:0006492" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the fibula" ; rdfs:subClassOf obo:HP_0002991, obo:HP_0006493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006493 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of the bones of the lower limbs." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4025037" ; oboInOwl:hasExactSynonym "Absent/small lower limb bones", "Absent/underdeveloped lower limb bones" ; oboInOwl:id "HP:0006493" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving bones of the lower limbs" ; rdfs:subClassOf obo:HP_0040069, obo:HP_0045060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006494 dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:08:00Z" ; oboInOwl:hasDbXref "UMLS:C4025036" ; oboInOwl:hasExactSynonym "Absent/small foot bones", "Absent/underdeveloped foot bones" ; oboInOwl:id "HP:0006494" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving bones of the feet" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0006493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006495 obo:IAO_0000115 "Absence or underdevelopment of the ulna." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:15:00Z" ; oboInOwl:hasAlternativeId "HP:0005097", "HP:0006372", "HP:0006410" ; oboInOwl:hasDbXref "UMLS:C1865571" ; oboInOwl:hasExactSynonym "Absence/underdevelopment of inner forearm bone", "Absent-hypoplastic ulnae", "Absent/small ulna", "Hypoplasia or unilateral/bilateral absence of ulna", "Ulnar hypoplasia/aplasia" ; oboInOwl:id "HP:0006495" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the ulna" ; rdfs:subClassOf obo:HP_0006503, obo:HP_0040071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006496 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of the bones of the upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:16:00Z" ; oboInOwl:hasDbXref "UMLS:C4025035" ; oboInOwl:hasExactSynonym "Absent/small bones of the upper limbs", "Absent/underdeveloped bones of the upper limbs" ; oboInOwl:id "HP:0006496" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving bones of the upper limbs" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0045060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006498 obo:IAO_0000115 "Absence or underdevelopment of the patella." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:25:00Z" ; oboInOwl:hasAlternativeId "HP:0005006", "HP:0005027", "HP:0005702", "HP:0005729", "HP:0006374" ; oboInOwl:hasDbXref "MSH:C535568", "UMLS:C1868577" ; oboInOwl:hasExactSynonym "Absent or hypoplastic patellae", "Absent/hypoplastic patella", "Absent/small kneecap", "Absent/underdeveloped kneecap", "Aplastic or hypoplastic patellae", "Hypoplastic or absent patella", "Patellar aplasia/hypoplasia", "Small to absent patellae" ; oboInOwl:id "HP:0006498" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the patella" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0006493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006499 obo:IAO_0000115 "An anomaly of a growth plate of a femur." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:28:00Z" ; oboInOwl:hasAlternativeId "HP:0006412", "HP:0008811" ; oboInOwl:hasDbXref "UMLS:C4025034" ; oboInOwl:hasExactSynonym "Abnormality of femoral epiphysis", "Abnormality of thighbone end part" ; oboInOwl:id "HP:0006499" ; a owl:Class ; rdfs:label "Abnormal femoral epiphysis morphology" ; rdfs:subClassOf obo:HP_0002823, obo:HP_0006500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006500 obo:IAO_0000115 "An anomaly of one or more epiphyses of one or both legs." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4021595" ; oboInOwl:hasExactSynonym "Abnormal shape of end part of lower limb end bone", "Abnormality involving the epiphyses of the lower limbs" ; oboInOwl:id "HP:0006500" ; a owl:Class ; rdfs:label "Abnormality of lower limb epiphysis morphology" ; rdfs:subClassOf obo:HP_0002814, obo:HP_0006505 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006501 obo:IAO_0000115 "A small/hypoplastic or absent/aplastic radius." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:32:00Z" ; oboInOwl:hasAlternativeId "HP:0005718" ; oboInOwl:hasDbXref "UMLS:C2749463" ; oboInOwl:hasExactSynonym "Absence or underdevelopment of the radius bone of the arm", "Absent/small radius", "Absent/underdeveloped radius", "Radial aplasia/hypoplasia" ; oboInOwl:id "HP:0006501" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0006503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006502 obo:IAO_0000115 "Absence or underdevelopment of the carpal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:35:00Z" ; oboInOwl:hasDbXref "UMLS:C4025033" ; oboInOwl:hasExactSynonym "Absent/small wrist bones", "Absent/underdeveloped wrist bones" ; oboInOwl:id "HP:0006502" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the carpal bones" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0005927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006503 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of one or more forearm bones." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:45:00Z" ; oboInOwl:hasDbXref "UMLS:C4025032" ; oboInOwl:hasExactSynonym "Absent/small forearm bones", "Absent/underdeveloped forearm bones" ; oboInOwl:id "HP:0006503" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving forearm bones" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006504 obo:IAO_0100001 "HP:0000940" ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:47:00Z" ; oboInOwl:hasExactSynonym "Abnormality of shaft of long bone of the limbs" ; oboInOwl:id "HP:0006504" ; a owl:Class ; rdfs:label "obsolete Anomaly of the limb diaphyses morphology" ; owl:deprecated true . obo:HP_0006505 obo:IAO_0000115 "An anomaly of one or more epiphyses of a limb." ; dcterms:creator ; oboInOwl:creation_date "2008-03-28T06:48:00Z" ; oboInOwl:hasDbXref "UMLS:C4021593" ; oboInOwl:hasExactSynonym "Abnormal shape of end part of limb bones", "Abnormality involving the epiphyses of the limbs", "Abnormality of limb epiphysis morphology" ; oboInOwl:id "HP:0006505" ; a owl:Class ; rdfs:comment "An epiphysis is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk." ; rdfs:label "Abnormal limb epiphysis morphology" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006507 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of the humerus." ; dcterms:creator ; oboInOwl:creation_date "2008-03-29T09:15:00Z" ; oboInOwl:hasDbXref "UMLS:C4025031" ; oboInOwl:hasExactSynonym "Absent/small long bone in upper arm", "Absent/underdeveloped long bone in upper arm" ; oboInOwl:id "HP:0006507" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the humerus" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0006496 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006508 dcterms:creator ; oboInOwl:creation_date "2008-03-29T09:19:00Z" ; oboInOwl:hasDbXref "UMLS:C4025030" ; oboInOwl:hasExactSynonym "Abnormality of end part of shinbone" ; oboInOwl:id "HP:0006508" ; a owl:Class ; rdfs:label "Abnormality of tibial epiphyses" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0006500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004383 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006509 obo:IAO_0000115 "Tracheal diverticula are blind-ended outpouchings arising from the trachea. They are usually an incidental finding. Occasionally they can mimic pneumomediastinum. Tracheal diverticula are either congenital or acquired, in the latter case the most common causes are prolonged increased intraluminal pressure, e.g. chronic cough, COPD, tracheomalacia, and iatrogenic (e.g. post-surgical)." ; oboInOwl:hasDbXref "SNOMEDCT_US:14011008", "UMLS:C0340213" ; oboInOwl:hasExactSynonym "Tracheal diverticulosis", "Tracheal diverticulum", "Tracheocele" ; oboInOwl:hasRelatedSynonym "Paratracheal air cyst" ; oboInOwl:id "HP:0006509" ; a owl:Class ; rdfs:label "Diverticulosis of trachea" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0006510 obo:IAO_0000115 "An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities." ; oboInOwl:hasAlternativeId "HP:0006541" ; oboInOwl:hasDbXref "MSH:D029424", "SNOMEDCT_US:13645005", "UMLS:C0024117" ; oboInOwl:hasExactSynonym "COPD", "Chronic obstructive pulmonary disease" ; oboInOwl:id "HP:0006510" ; a owl:Class ; rdfs:comment "COPD is usually conceptualized as a disease entity. It is heterogeneous histologically and pathogenically, and conventionally includes emphysema and chronic bronchitis, It is included as a phenotype term as COPD is often annotated as a feature of other diseases." ; rdfs:label "Chronic pulmonary obstruction" ; rdfs:subClassOf obo:HP_0006536 . obo:HP_0006511 obo:IAO_0000115 "An abnormal high-pitched noisy sound, occurring during inhalation or exhalation caused by the incomplete obstruction in the throat." ; oboInOwl:hasDbXref "MSH:D007826", "SNOMEDCT_US:406444002", "SNOMEDCT_US:41432000", "SNOMEDCT_US:53787002", "UMLS:C0023066" ; oboInOwl:hasExactSynonym "Laryngeal stidor" ; oboInOwl:id "HP:0006511" ; a owl:Class ; rdfs:comment "The laryngeal stridor sound is usually heard during inspiratory phase, also called inspiratory stridor, and may accompanied by inspiratory difficulty in breathing. It may be due to abnormal flaccidity of the epiglottis or arytenoids." ; rdfs:label "Laryngeal stridor" ; rdfs:subClassOf obo:HP_0025424 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010307 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006514 oboInOwl:hasDbXref "UMLS:C4025028" ; oboInOwl:id "HP:0006514" ; a owl:Class ; rdfs:label "Intraalveolar nodular calcifications" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0033137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002299 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006515 oboInOwl:hasDbXref "MSH:D017563", "SNOMEDCT_US:64667001", "UMLS:C0206061" ; oboInOwl:id "HP:0006515" ; a owl:Class ; rdfs:label "Interstitial pneumonitis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0006516 obo:IAO_0000115 "Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen: fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache and can be completely reversible, based on the duration of the illness, categorized as acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010)." ; oboInOwl:hasDbXref "MSH:D000542", "SNOMEDCT_US:37471005", "UMLS:C0002390" ; oboInOwl:id "HP:0006516" ; a owl:Class ; rdfs:comment "Hypersensitivity pneumonitis may also be called many different names, based on the provoking antigen." ; rdfs:label "Hypersensitivity pneumonitis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0006517 obo:IAO_0000115 "Accumulation of amorphous PAS-positive material in the space betweem alveolar macrophages, sometimes as condensed form (oval bodies) are typically found in alveolar proteinosis." ; oboInOwl:hasAlternativeId "HP:0032982" ; oboInOwl:hasDbXref "MSH:D011649", "SNOMEDCT_US:10501004", "UMLS:C0034050" ; oboInOwl:hasExactSynonym "Alveolar proteinosis", "Detection of PAS-positive extracellular material in broncho-alveolar lavage", "Pulmonary alveolar proteinosis" ; oboInOwl:id "HP:0006517" ; a owl:Class ; rdfs:comment "The periodic acid Schiff (PAS) staining is a staining method that detects polysaccharidese and mucosubstances, for example: glycogen, glyolipids, glyoproteins and mucins. It is one of the commonly used procedures in the histophathology laboratory and is easy to perfom. It may help in discriminating different forms of interstitial lung disease (ILD), especially pulmonary alveolar proteinosis (PAP)." ; rdfs:label "Intraalveolar phospholipid accumulation" ; rdfs:subClassOf obo:HP_0032973 . obo:HP_0006518 obo:IAO_0000115 "Substantial narrowing or blockage of small pulmonary veins as a result of disorganized smooth muscle hypertrophy and collagen matrix deposition." ; oboInOwl:hasDbXref "Fyler:3002", "MSH:D011668", "SNOMEDCT_US:89420002", "UMLS:C0034091", "UMLS:C4280802" ; oboInOwl:hasExactSynonym "Pulmonary venous stenosis" ; oboInOwl:hasRelatedSynonym "Pulmonary venoocclusive disease" ; oboInOwl:id "HP:0006518" ; a owl:Class ; rdfs:comment "This feature can be observed by histological examination of lung tissue. The feature can be seen in pulmonary veno-occlusive disease (PVOD). PVOD is characterised by diffuse occlusion of the pulmonary veins by fibrous tissue, pulmonary venous congestion and associated complications including severe pulmonary hypertension (pHTN), non-cardiogenic pulmonary oedema, hypoxia and right-ventricular failure. Clinical presentation is typically non-specific, including dyspnoea, fatigue and cough." ; rdfs:label "Pulmonary venous occlusion" ; rdfs:subClassOf obo:HP_0030968 . obo:HP_0006519 obo:IAO_0000115 "Adenocarcinoma of the Bronchus." ; oboInOwl:hasAlternativeId "HP:0006757" ; oboInOwl:hasDbXref "MSH:D002282", "SNOMEDCT_US:112677002", "SNOMEDCT_US:36310008", "SNOMEDCT_US:373627005", "UMLS:C0007120" ; oboInOwl:id "HP:0006519" ; a owl:Class ; rdfs:label "Alveolar cell carcinoma" ; rdfs:subClassOf obo:HP_0100552 . obo:HP_0006520 oboInOwl:hasDbXref "UMLS:C1849570" ; oboInOwl:id "HP:0006520" ; a owl:Class ; rdfs:label "Progressive pulmonary function impairment" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0006521 obo:IAO_0000115 "Abnormal dilatation of the pulmonary lymphatic vessels. Lymphatic fluid in the lung is derived from normal leakage of fluid out of the blood capillaries in the lung. In pulmonary lymphangiectasia, the pulmonary lymphatics are not properly connected and become dilated with fluid." ; oboInOwl:hasAlternativeId "HP:0006526", "HP:0006551" ; oboInOwl:hasDbXref "UMLS:C1855480" ; oboInOwl:hasExactSynonym "Pulmonary lymphangiectasis" ; oboInOwl:id "HP:0006521" ; a owl:Class ; rdfs:label "Pulmonary lymphangiectasia" ; rdfs:subClassOf obo:HP_0006529, obo:HP_0031842 . obo:HP_0006522 oboInOwl:hasDbXref "UMLS:C4025027" ; oboInOwl:hasExactSynonym "Repeated pneumothorax" ; oboInOwl:id "HP:0006522" ; a owl:Class ; rdfs:label "Repeated pneumothoraces" ; rdfs:subClassOf obo:HP_0002107 . obo:HP_0006524 oboInOwl:hasDbXref "UMLS:C3806786" ; oboInOwl:id "HP:0006524" ; a owl:Class ; rdfs:label "Tracheobronchial leiomyomatosis" ; rdfs:subClassOf obo:HP_0100552 . obo:HP_0006525 obo:IAO_0100001 "HP:0002101" ; oboInOwl:id "HP:0006525" ; a owl:Class ; rdfs:label "obsolete Lung segmentation defects" ; owl:deprecated true . obo:HP_0006527 obo:IAO_0000115 "Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa." ; oboInOwl:hasDbXref "MSH:C562489", "SNOMEDCT_US:44274007", "UMLS:C0264511" ; oboInOwl:hasExactSynonym "Lymphocytic interstitial pneumonitis", "Lymphoid interstitial pneumonia", "Lymphoid interstitial pneumonitis" ; oboInOwl:id "HP:0006527" ; a owl:Class ; rdfs:comment "Lymphocytic interstitial pneumonitis is assumed to be a pathological immunologic response to different triggers and are particularly associated with autoimmune and infectious diseases as well as immunodeficiency. Associated clinical manifestations often include fever, cough, and shortness of breath." ; rdfs:label "Lymphocytic interstitial pneumonia" ; rdfs:subClassOf obo:HP_0006515, obo:HP_0033582 . obo:HP_0006528 obo:IAO_0000115 "According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities." ; oboInOwl:hasDbXref "SNOMEDCT_US:413839001", "UMLS:C0746102" ; oboInOwl:hasExactSynonym "Chronic lung disease" ; oboInOwl:id "HP:0006528" ; a owl:Class ; rdfs:label "Chronic lung disease" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0006529 obo:IAO_0000115 "An abnormality of the pulmonary lymphatic chain." ; oboInOwl:hasDbXref "UMLS:C4025026" ; oboInOwl:id "HP:0006529" ; a owl:Class ; rdfs:label "Abnormal pulmonary lymphatics" ; rdfs:subClassOf obo:HP_0002088, obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0018226 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006530 obo:IAO_0000115 "Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis." ; oboInOwl:hasAlternativeId "HP:0006513", "HP:0006547" ; oboInOwl:hasDbXref "MSH:D017563", "SNOMEDCT_US:233703007", "UMLS:C0206062" ; oboInOwl:hasExactSynonym "Abnormal lung parenchyma morphology", "Abnormality in area between air sacs in lung", "Interstitial lung disease", "Interstitial pulmonary disease" ; oboInOwl:id "HP:0006530" ; a owl:Class ; rdfs:label "Abnormal pulmonary interstitial morphology" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0006531 oboInOwl:hasDbXref "UMLS:C1856139" ; oboInOwl:id "HP:0006531" ; a owl:Class ; rdfs:label "Pleural lymphangiectasia" ; rdfs:subClassOf obo:HP_0002103, obo:HP_0031842 . obo:HP_0006532 obo:IAO_0000115 "An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia." ; oboInOwl:hasAlternativeId "HP:0002095", "HP:0002096" ; oboInOwl:hasDbXref "SNOMEDCT_US:128601007", "SNOMEDCT_US:699014000", "UMLS:C0694550", "UMLS:C0748140", "UMLS:C0876973", "UMLS:C1859117" ; oboInOwl:hasExactSynonym "Multiple pulmonary infections", "Pneumonia, recurrent", "Pneumonia, recurrent episodes", "Pulmonary infection", "Pulmonary infections", "Recurrent pneumonia", "Recurrent pulmonary infections", "pulmonary infections, recurrent" ; oboInOwl:id "HP:0006532" ; a owl:Class ; rdfs:comment "Recurrent pneumonia is defined as two or more episodes in a single year, or at least three episodes ever, with radiographic clearing of densities between occurrences." ; rdfs:label "Recurrent pneumonia" ; rdfs:subClassOf obo:HP_0002090, obo:HP_0002783 . obo:HP_0006533 oboInOwl:hasDbXref "UMLS:C4025025" ; oboInOwl:id "HP:0006533" ; a owl:Class ; rdfs:label "Bronchodysplasia" ; rdfs:subClassOf obo:HP_0025426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002185 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006535 obo:IAO_0000115 "A recurrent hemorrhage occurring within the lung." ; oboInOwl:hasDbXref "UMLS:C3805919" ; oboInOwl:hasExactSynonym "Recurrent bleeding into lungs", "Recurrent intrapulmonary haemorrhage", "Recurrent pulmonary haemorrhage", "Recurrent pulmonary hemorrhage" ; oboInOwl:id "HP:0006535" ; a owl:Class ; rdfs:label "Recurrent intrapulmonary hemorrhage" ; rdfs:subClassOf obo:HP_0040223 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001561 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006536 obo:IAO_0000115 "Obstruction of conducting airways of the lung." ; oboInOwl:hasAlternativeId "HP:0006512" ; oboInOwl:hasDbXref "MSH:D008173", "UMLS:C0600260" ; oboInOwl:hasExactSynonym "Obstructive lung disease", "Pulmonary obstruction" ; oboInOwl:id "HP:0006536" ; a owl:Class ; rdfs:label "Airway obstruction" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0006538 obo:IAO_0000115 "An increased susceptibility to bronchopulmonary infections as manifested by a history of recurrent bronchopulmonary infections." ; oboInOwl:hasBroadSynonym "Recurrent infections in bronchi and lungs" ; oboInOwl:hasDbXref "UMLS:C2169795" ; oboInOwl:id "HP:0006538" ; a owl:Class ; rdfs:label "Recurrent bronchopulmonary infections" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0006539 oboInOwl:hasDbXref "UMLS:C4025024" ; oboInOwl:hasExactSynonym "Underdevelopment of the bronical cartilage" ; oboInOwl:id "HP:0006539" ; a owl:Class ; rdfs:label "Bronchial cartilage hypoplasia" ; rdfs:subClassOf obo:HP_0025426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006541 obo:IAO_0100001 "HP:0006510" ; oboInOwl:id "HP:0006541" ; a owl:Class ; rdfs:label "obsolete Chronic obstructive airway disease from birth" ; owl:deprecated true . obo:HP_0006543 oboInOwl:hasDbXref "MSH:D006323", "SNOMEDCT_US:410430005", "UMLS:C0600228" ; oboInOwl:id "HP:0006543" ; a owl:Class ; rdfs:label "Cardiorespiratory arrest" ; rdfs:subClassOf obo:HP_0005943 . obo:HP_0006544 obo:IAO_0000115 "A type of pulmonary sequestration that is completely enclosed in its own pleural sac, occurring above, within, or below the diaphragm, and without communication with the tracheobronchial tree." ; oboInOwl:hasDbXref "UMLS:C4020814", "UMLS:C4025023" ; oboInOwl:hasRelatedSynonym "Diaphragmatic sequestrum" ; oboInOwl:id "HP:0006544" ; a owl:Class ; rdfs:comment "Extrapulmonary sequestra nearly all appear on the left side." ; rdfs:label "Extrapulmonary sequestrum" ; rdfs:subClassOf obo:HP_0100632 . obo:HP_0006548 obo:IAO_0000115 "Pulmonary arteriovenous malformation, a condition most commonly associated with hereditary hemorrhagic telangiectasia, is an abnormal communication between the pulmonary artery and pulmonary vein without an intervening capillary communication. HRCT images usually show a coarse spidery appearance of the peripheral vascular markings in the lungs. More specific findings are obtained in the pulmonary angiogram where the normally invisible capillary phase is replaced by irregular vascular channels bridging the peripheral branches of pulmonary arteries and veins." ; oboInOwl:hasAlternativeId "HP:0002114", "HP:0006537" ; oboInOwl:hasDbXref "Fyler:2210", "UMLS:C1857690" ; oboInOwl:hasExactSynonym "Pulmonary AV malformation" ; oboInOwl:id "HP:0006548" ; a owl:Class ; rdfs:label "Pulmonary arteriovenous malformation" ; rdfs:subClassOf obo:HP_0004930, obo:HP_0100026 . obo:HP_0006549 oboInOwl:hasDbXref "UMLS:C4021592" ; oboInOwl:hasExactSynonym "Primary pulmonary dysgenesis, unilateral" ; oboInOwl:id "HP:0006549" ; a owl:Class ; rdfs:label "Unilateral primary pulmonary dysgenesis" ; rdfs:subClassOf obo:HP_4000059 . obo:HP_0006552 oboInOwl:hasDbXref "UMLS:C1397290" ; oboInOwl:id "HP:0006552" ; a owl:Class ; rdfs:label "Fibrocystic lung disease" ; rdfs:subClassOf obo:HP_0005948 . obo:HP_0006554 obo:IAO_0000115 "Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver." ; oboInOwl:hasAlternativeId "HP:0006556" ; oboInOwl:hasDbXref "MSH:D017114", "SNOMEDCT_US:197270009", "SNOMEDCT_US:235884008", "UMLS:C0162557" ; oboInOwl:hasExactSynonym "Acute liver failure" ; oboInOwl:id "HP:0006554" ; a owl:Class ; rdfs:label "Acute hepatic failure" ; rdfs:subClassOf obo:HP_0001399 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006555 obo:IAO_0000115 "A diffuse form of hepatic steatosis." ; oboInOwl:hasDbXref "UMLS:C1849686" ; oboInOwl:hasExactSynonym "Hepatic steatosis, diffuse" ; oboInOwl:id "HP:0006555" ; a owl:Class ; rdfs:label "Diffuse hepatic steatosis" ; rdfs:subClassOf obo:HP_0001397 . obo:HP_0006557 oboInOwl:hasDbXref "MSH:C536330", "SNOMEDCT_US:72925005", "UMLS:C0158683" ; oboInOwl:id "HP:0006557" ; a owl:Class ; rdfs:label "Polycystic liver disease" ; rdfs:subClassOf obo:HP_0006706 . obo:HP_0006558 obo:IAO_0000115 "Decreased activity of complex III of the mitochondrion in the liver." ; oboInOwl:hasDbXref "UMLS:C4025022" ; oboInOwl:id "HP:0006558" ; a owl:Class ; rdfs:comment "Complex III, also known as ubiquinol-cytochrome c oxidoreductase or cytochrome bc1 complex, is a multisubunit integral membrane complex of the mitochondrial transport chain, which catalyzes electron transfer from ubiquinol to cytochrome c and couples this process to electrogenic translocation of protons across the mitochondrial inner membrane. Mitochondrial complex III is integrated in the inner mitochondrial membrane." ; rdfs:label "Decreased mitochondrial complex III activity in liver tissue" ; rdfs:subClassOf obo:HP_0025155 . obo:HP_0006559 obo:IAO_0000115 "The presence of abnormal calcium deposition in the liver." ; oboInOwl:hasDbXref "UMLS:C1696466" ; oboInOwl:hasExactSynonym "Liver calcifications" ; oboInOwl:id "HP:0006559" ; a owl:Class ; rdfs:label "Hepatic calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006560 obo:IAO_0000115 "Hyperplasia of the biliary tree, as manifested by increased size of bile ducts, dilated lumen, and histologically by an increased number of epithelial cells or hyperplasia." ; oboInOwl:hasDbXref "UMLS:C3672440", "UMLS:C3686778" ; oboInOwl:hasExactSynonym "Bile duct hyperplasia" ; oboInOwl:id "HP:0006560" ; a owl:Class ; rdfs:label "Biliary hyperplasia" ; rdfs:subClassOf obo:HP_0012440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006561 oboInOwl:hasDbXref "UMLS:C1837257" ; oboInOwl:id "HP:0006561" ; a owl:Class ; rdfs:label "Lipid accumulation in hepatocytes" ; rdfs:subClassOf obo:HP_0031137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18059 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000182 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006562 obo:IAO_0000115 "Inflammation of the liver due to infection with a virus." ; oboInOwl:hasDbXref "SNOMEDCT_US:3738000", "UMLS:C0042721" ; oboInOwl:id "HP:0006562" ; a owl:Class ; rdfs:label "Viral hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0006563 oboInOwl:hasDbXref "UMLS:C1857519" ; oboInOwl:id "HP:0006563" ; a owl:Class ; rdfs:label "Malformation of the hepatic ductal plate" ; rdfs:subClassOf obo:HP_0004297 . obo:HP_0006564 obo:IAO_0000115 "Intermittently increased size of the liver." ; oboInOwl:hasDbXref "UMLS:C1835881" ; oboInOwl:id "HP:0006564" ; a owl:Class ; rdfs:label "Fluctuating hepatomegaly" ; rdfs:subClassOf obo:HP_0002240 . obo:HP_0006565 obo:IAO_0000115 "An abnormal increase in the amount of intracellular lipid droplets in hepatocytes." ; oboInOwl:hasDbXref "UMLS:C4025021" ; oboInOwl:id "HP:0006565" ; a owl:Class ; rdfs:comment "Lipid droplets, rich in triglycerides and cholesterol esters, are cellular lipid storage organelles." ; rdfs:label "Increased hepatocellular lipid droplets" ; rdfs:subClassOf obo:HP_0006561 . obo:HP_0006566 oboInOwl:hasDbXref "UMLS:C1859162" ; oboInOwl:id "HP:0006566" ; a owl:Class ; rdfs:label "Neonatal cholestatic liver disease" ; rdfs:subClassOf obo:HP_0002611 . obo:HP_0006568 obo:IAO_0000115 "An increase in the amount of glycogen stored in hepatocytes compared to normal." ; oboInOwl:hasDbXref "UMLS:C1856285" ; oboInOwl:hasExactSynonym "Increased liver glycogen content" ; oboInOwl:id "HP:0006568" ; a owl:Class ; rdfs:comment "Glycogen acts as secondary long-term energy storage in the liver and other organs. Its intracellular concentration can be increased in some disease states such as obesity." ; rdfs:label "Increased hepatic glycogen content" ; rdfs:subClassOf obo:HP_0500030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006571 obo:IAO_0000115 "The presence of reduced numbers of intrahepatic bile duct than normal." ; oboInOwl:hasDbXref "UMLS:C1861621", "UMLS:C4021591" ; oboInOwl:hasExactSynonym "Hepatic ductopenia" ; oboInOwl:hasRelatedSynonym "Intrahepatic duct deficiency" ; oboInOwl:id "HP:0006571" ; a owl:Class ; rdfs:label "Reduced number of intrahepatic bile ducts" ; rdfs:subClassOf obo:HP_0011040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003704 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006572 oboInOwl:hasDbXref "UMLS:C1861901" ; oboInOwl:id "HP:0006572" ; a owl:Class ; rdfs:label "Subacute progressive viral hepatitis" ; rdfs:subClassOf obo:HP_0006562 . obo:HP_0006573 obo:IAO_0000115 "An acute form of hepatic steatosis." ; oboInOwl:hasDbXref "UMLS:C4025020" ; oboInOwl:hasExactSynonym "Acute fatty liver" ; oboInOwl:id "HP:0006573" ; a owl:Class ; rdfs:label "Acute hepatic steatosis" ; rdfs:subClassOf obo:HP_0001397 . obo:HP_0006574 oboInOwl:hasAlternativeId "HP:0006569" ; oboInOwl:hasDbXref "SNOMEDCT_US:84150000", "UMLS:C0520557" ; oboInOwl:hasExactSynonym "Liver arteriovenous malformation" ; oboInOwl:id "HP:0006574" ; a owl:Class ; rdfs:label "Hepatic arteriovenous malformation" ; rdfs:subClassOf obo:HP_0006707, obo:HP_0100026 . obo:HP_0006575 oboInOwl:hasDbXref "UMLS:C4025019" ; oboInOwl:id "HP:0006575" ; a owl:Class ; rdfs:label "Intrahepatic cholestasis with episodic jaundice" ; rdfs:subClassOf obo:HP_0001406 . obo:HP_0006576 oboInOwl:hasDbXref "UMLS:C1861790" ; oboInOwl:hasExactSynonym "Liver vascular malformations" ; oboInOwl:id "HP:0006576" ; a owl:Class ; rdfs:label "Hepatic vascular malformations" ; rdfs:subClassOf obo:HP_0006707 . obo:HP_0006577 obo:IAO_0000115 "A type of cirrhosis characterized by the presence of large regenerative nodules." ; oboInOwl:hasDbXref "SNOMEDCT_US:43904005", "SNOMEDCT_US:86454000", "UMLS:C2004456" ; oboInOwl:id "HP:0006577" ; a owl:Class ; rdfs:comment "In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm." ; rdfs:label "Macronodular cirrhosis" ; rdfs:subClassOf obo:HP_0001394 . obo:HP_0006579 obo:IAO_0000115 "Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants." ; oboInOwl:hasAlternativeId "HP:0000986" ; oboInOwl:hasDbXref "MSH:D007567", "SNOMEDCT_US:387712008", "UMLS:C0022353", "UMLS:C1859236" ; oboInOwl:hasExactSynonym "Neonatal jaundice", "Prolonged yellowing of skin in newborn" ; oboInOwl:hasRelatedSynonym "Jaundice, neonatal" ; oboInOwl:id "HP:0006579" ; a owl:Class ; rdfs:label "Prolonged neonatal jaundice" ; rdfs:subClassOf obo:HP_0000952 . obo:HP_0006580 obo:IAO_0000115 "Fibroblast proliferation and fiber expansion from the portal areas to the lobule." ; oboInOwl:hasDbXref "UMLS:C2677002", "UMLS:C3805083" ; oboInOwl:hasRelatedSynonym "Portal fibrosis shown on biopsy" ; oboInOwl:id "HP:0006580" ; a owl:Class ; rdfs:comment "Portal fibrosis can be seen in viral hepatitis and other types of liver disease." ; rdfs:label "Portal fibrosis" ; rdfs:subClassOf obo:HP_0004297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006581 obo:IAO_0000115 "An abnormal reduction in the number of mitochondria in hepatocytes." ; oboInOwl:hasDbXref "UMLS:C4025018" ; oboInOwl:id "HP:0006581" ; a owl:Class ; rdfs:label "Depletion of mitochondrial DNA in liver" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0006582 obo:IAO_0000115 "Repeated occurrences of acute noninflammatory encephalopathy and fatty degenerative liver failure." ; oboInOwl:hasDbXref "UMLS:C1850413" ; oboInOwl:id "HP:0006582" ; a owl:Class ; rdfs:comment "This feature has been observed in individuals withe mitochondrial DNA depletion syndrome-6 (MTDPS6), also known as Navajo neurohepatopathy [MIM:256810]." ; rdfs:label "Reye syndrome-like episodes" ; rdfs:subClassOf obo:HP_0025155 . obo:HP_0006583 oboInOwl:hasDbXref "UMLS:C4025017" ; oboInOwl:hasExactSynonym "Fatal liver failure in infancy" ; oboInOwl:id "HP:0006583" ; a owl:Class ; rdfs:label "Fatal liver failure in infancy" ; rdfs:subClassOf obo:HP_0001399 . obo:HP_0006584 oboInOwl:hasAlternativeId "HP:0006629" ; oboInOwl:hasDbXref "UMLS:C1861226" ; oboInOwl:hasExactSynonym "Small abnormally formed scapula", "Small abnormally formed shoulder blade" ; oboInOwl:id "HP:0006584" ; a owl:Class ; rdfs:label "Small abnormally formed scapulae" ; rdfs:subClassOf obo:HP_0000882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000782 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0000882 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006585 obo:IAO_0000115 "The two portions of the clavicle (corresponding to the two primary ossification centers of the clavicle) are connected by a fibrous bridge that is contiguous with the periosteum, and a synovial membrane develops, resulting in a clavicle with a bipartite appearance radiographically. Congenital pseudarthrosis of the clavicle generally presents as a painless mass or swelling over the clavicle." ; oboInOwl:hasAlternativeId "HP:0006612", "HP:0006661" ; oboInOwl:hasDbXref "SNOMEDCT_US:249685004", "SNOMEDCT_US:249690001", "UMLS:C0426806", "UMLS:C0426811" ; oboInOwl:hasExactSynonym "Clavicle pseudoarthrosis", "Pseudoarthrosis of clavicle" ; oboInOwl:hasRelatedSynonym "Bipartite clavicle" ; oboInOwl:id "HP:0006585" ; a owl:Class ; rdfs:comment "In congenital pseudarthrosis of the clavicle, the two primary ossification centers fail to unite, probably due to a disruption of diaphyseal membranous ossification. See PMID:22295044, Figure 1, for the radiographic appearance of this feature." ; rdfs:label "Congenital pseudoarthrosis of the clavicle" ; rdfs:subClassOf obo:HP_0005864, obo:HP_0006710 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005864 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006587 obo:IAO_0000115 "An abnormally straight configuration of the clavicle, a tubular bone which normally is doubly curved ." ; oboInOwl:hasDbXref "UMLS:C4025016" ; oboInOwl:hasExactSynonym "Straight collarbone" ; oboInOwl:id "HP:0006587" ; a owl:Class ; rdfs:label "Straight clavicles" ; rdfs:subClassOf obo:HP_0000889 . obo:HP_0006589 oboInOwl:hasDbXref "UMLS:C1855196" ; oboInOwl:hasExactSynonym "Flaring of lower rib cage" ; oboInOwl:id "HP:0006589" ; a owl:Class ; rdfs:label "Flaring of lower rib cage" ; rdfs:subClassOf obo:HP_0000904 . obo:HP_0006590 obo:IAO_0000115 "Prematurely closed sternal sutures." ; oboInOwl:hasDbXref "UMLS:C4021590" ; oboInOwl:hasExactSynonym "Prematurely closed sternal sutures" ; oboInOwl:id "HP:0006590" ; a owl:Class ; rdfs:label "Premature sternal synostosis" ; rdfs:subClassOf obo:HP_0006714 . obo:HP_0006591 obo:IAO_0000115 "Lack of development of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." ; oboInOwl:hasDbXref "UMLS:C4021589" ; oboInOwl:hasExactSynonym "Aplasia of the glenoid fossa" ; oboInOwl:id "HP:0006591" ; a owl:Class ; rdfs:label "Absent glenoid fossa" ; rdfs:subClassOf obo:HP_0011912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006593 oboInOwl:hasDbXref "UMLS:C1861704" ; oboInOwl:id "HP:0006593" ; a owl:Class ; rdfs:label "Anomalous rib insertion to vertebrae" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0006595 obo:IAO_0000115 "Bony fusion between the humerus and scapula, leading to an impairment in mobility of the affected shoulder joint." ; oboInOwl:hasAlternativeId "HP:0010792" ; oboInOwl:hasDbXref "UMLS:C1865362" ; oboInOwl:hasExactSynonym "Fusion of shoulder blade to long bone in upper arm", "Humero-scapulo synostosis", "Humeroscapular synostosis", "Synostosis of shoulder joint" ; oboInOwl:id "HP:0006595" ; a owl:Class ; rdfs:label "Scapulohumeral synostosis" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0001376, obo:HP_0003043, obo:HP_0003063, obo:HP_0100238 . obo:HP_0006596 oboInOwl:hasDbXref "UMLS:C4025015" ; oboInOwl:hasExactSynonym "Restricted chest movement" ; oboInOwl:id "HP:0006596" ; a owl:Class ; rdfs:label "Restricted chest movement" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0001547 . obo:HP_0006597 obo:IAO_0000115 "The presence of a paralyzed diaphragm." ; oboInOwl:hasDbXref "MSH:D012133", "SNOMEDCT_US:64228003", "UMLS:C0035232" ; oboInOwl:hasExactSynonym "Diaphragmatic paralysis", "Paralysed diaphragm", "Paralyzed diaphragm" ; oboInOwl:id "HP:0006597" ; a owl:Class ; rdfs:comment "Loss of the ability to move the diaphragm for respiratory motions. Patients with complete diaphragm paralysis complain of gross orthopnoea, disturbed sleep and early morning headaches. They have shortness of breath on minimal exertion and, because they sleep poorly, they experience daytime fatigue." ; rdfs:label "Diaphragmatic paralysis" ; rdfs:subClassOf obo:HP_0003470, obo:HP_0009113 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006598 oboInOwl:hasDbXref "UMLS:C1850083" ; oboInOwl:id "HP:0006598" ; a owl:Class ; rdfs:label "Irregular ossification at anterior rib ends" ; rdfs:subClassOf obo:HP_0012306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002235 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006599 oboInOwl:hasDbXref "UMLS:C1866729" ; oboInOwl:id "HP:0006599" ; a owl:Class ; rdfs:label "Medial widening of clavicles" ; rdfs:subClassOf obo:HP_0000889 . obo:HP_0006600 oboInOwl:hasDbXref "UMLS:C1968577" ; oboInOwl:id "HP:0006600" ; a owl:Class ; rdfs:label "Progressive calcification of costochondral cartilage" ; rdfs:subClassOf obo:HP_0000919, obo:HP_0100593 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006603 oboInOwl:hasDbXref "UMLS:C1865833" ; oboInOwl:hasExactSynonym "Flared, irregular rib ends" ; oboInOwl:id "HP:0006603" ; a owl:Class ; rdfs:label "Flared, irregular rib ends" ; rdfs:subClassOf obo:HP_0000887 . obo:HP_0006606 obo:IAO_0000115 "Irregular surface of the normally relatively smooth border between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." ; oboInOwl:hasAlternativeId "HP:0006658" ; oboInOwl:hasDbXref "UMLS:C1861199" ; oboInOwl:hasExactSynonym "Irregular costochondral margins" ; oboInOwl:id "HP:0006606" ; a owl:Class ; rdfs:comment "The first seven pairs of ribs are connected with the sternum; the next three ribs are each articulated with the lower border of the cartilage of the preceding rib; the last two ribs have pointed extremities, which do not connect with the sternum." ; rdfs:label "Irregular chondrocostal junctions" ; rdfs:subClassOf obo:HP_0000919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006607 obo:IAO_0000115 "Early ossification of the costochondral junction, which is the joint between the ribs and costal cartilage in the front of the rib cage." ; oboInOwl:hasDbXref "UMLS:C1849049" ; oboInOwl:id "HP:0006607" ; a owl:Class ; rdfs:comment "The costal cartilage typically calcifies with advancing age and is therefore easier to identify on radiographs obtained in older patients." ; rdfs:label "Precocious costochondral ossification" ; rdfs:subClassOf obo:HP_0000919, obo:HP_0004348, obo:HP_0012306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002293 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006608 obo:IAO_0000115 "Underdevelopment of the middle portion of the clavicle." ; oboInOwl:hasDbXref "UMLS:C1844530" ; oboInOwl:hasExactSynonym "Underdeveloped middle portion of the collarbone" ; oboInOwl:id "HP:0006608" ; a owl:Class ; rdfs:label "Midclavicular hypoplasia" ; rdfs:subClassOf obo:HP_0000894 . obo:HP_0006610 obo:IAO_0000115 "A larger than usual distance between the left and right nipple." ; oboInOwl:hasAlternativeId "HP:0000779", "HP:0001554" ; oboInOwl:hasDbXref "SNOMEDCT_US:423230008", "UMLS:C1827524" ; oboInOwl:hasExactSynonym "Wide-spaced nipples", "Widely spaced nipples", "Widely-spaced nipples" ; oboInOwl:id "HP:0006610" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Wide intermamillary distance" ; rdfs:subClassOf obo:HP_0040157 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006611 obo:IAO_0000115 "A less than normal number of sternal ossification centers. The sternum is initially formed from bilateral sternal plates that chondrify and begin to fuse with ribs at 10 weeks gestational age. Ossification starts in the manubrium and upper part of the sternal body at the 6th month, in the middle of the sternal body at the 7th month, in the lower part of the body during the 1st postnatal year and in the xiphoid process between years 5 and 18. The number of ossification centers vary up to six, and it is the ossification centers that are visualized by prenatal ultrasound. This term describes a reduction in the number of ossification centers compared with age-related norms." ; oboInOwl:hasDbXref "UMLS:C1856223" ; oboInOwl:hasExactSynonym "Decreased number of sternal ossification centres" ; oboInOwl:id "HP:0006611" ; a owl:Class ; rdfs:label "Decreased number of sternal ossification centers" ; rdfs:subClassOf obo:HP_0011863 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006615 obo:IAO_0000115 "Lack of formation and mineralization of the ribs in utero." ; oboInOwl:hasDbXref "UMLS:C1842695" ; oboInOwl:hasExactSynonym "Absent rib calcification in utero" ; oboInOwl:id "HP:0006615" ; a owl:Class ; rdfs:label "Absent in utero rib ossification" ; rdfs:subClassOf obo:HP_0012306 . obo:HP_0006619 obo:IAO_0000115 "Deposition of calcium salts in point-like foci within the anterior portion of one or more ribs." ; oboInOwl:hasDbXref "UMLS:C1859120" ; oboInOwl:id "HP:0006619" ; a owl:Class ; rdfs:label "Anterior rib punctate calcifications" ; rdfs:subClassOf obo:HP_0012306, obo:HP_0040059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_4100117 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0006623 obo:IAO_0000115 "Abnormal increase in density of the tissue at the costochondral junctions." ; oboInOwl:hasDbXref "UMLS:C4021588" ; oboInOwl:hasExactSynonym "Sclerotic costochondral joints" ; oboInOwl:id "HP:0006623" ; a owl:Class ; rdfs:label "Costochondral joint sclerosis" ; rdfs:subClassOf obo:HP_0000919 . obo:HP_0006625 obo:IAO_0000115 "Breast carcinoma that is bilateral or otherwise multifocal." ; oboInOwl:hasDbXref "UMLS:C2986662" ; oboInOwl:hasExactSynonym "Multifocal breast cancer" ; oboInOwl:id "HP:0006625" ; a owl:Class ; rdfs:label "Multifocal breast carcinoma" ; rdfs:subClassOf obo:HP_0003002 . obo:HP_0006628 obo:IAO_0000115 "Lack of formation of mineralized bony tissue of the sternum." ; oboInOwl:hasAlternativeId "HP:0006654", "HP:0006666" ; oboInOwl:hasDbXref "UMLS:C1857074", "UMLS:C4280443" ; oboInOwl:hasExactSynonym "Absent sternal mineralization", "Lack of sternal ossification" ; oboInOwl:hasRelatedSynonym "Absent bone maturation in sternum" ; oboInOwl:id "HP:0006628" ; a owl:Class ; rdfs:label "Absent sternal ossification" ; rdfs:subClassOf obo:HP_0006714, obo:HP_0011863 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006631 oboInOwl:hasBroadSynonym "Small outermost segments of shoulder blade" ; oboInOwl:hasDbXref "UMLS:C4025014" ; oboInOwl:hasExactSynonym "Small distal segments of the shoulder blade", "Underdeveloped outermost segments of shoulder blade" ; oboInOwl:id "HP:0006631" ; a owl:Class ; rdfs:label "Hypoplastic distal segments of scapulae" ; rdfs:subClassOf obo:HP_0000882 . obo:HP_0006633 obo:IAO_0000115 "Underdevelopment of the glenoid fossa, which is the cavity in the lateral part of the scapula which articulates with the head of the humerus." ; oboInOwl:hasAlternativeId "HP:0006632" ; oboInOwl:hasDbXref "UMLS:C1834384" ; oboInOwl:hasExactSynonym "Glenoid hypoplasia", "Hypoplastic glenoid fossa" ; oboInOwl:id "HP:0006633" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Glenoid fossa hypoplasia" ; rdfs:subClassOf obo:HP_0011912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006634 obo:IAO_0000115 "Osteosclerosis of ribs (increased density related to increased bone mass)." ; oboInOwl:hasDbXref "UMLS:C4025013" ; oboInOwl:hasExactSynonym "Increased bone density in ribs" ; oboInOwl:id "HP:0006634" ; a owl:Class ; rdfs:label "Osteosclerosis of ribs" ; rdfs:subClassOf obo:HP_0012306 . obo:HP_0006637 oboInOwl:hasDbXref "UMLS:C1859121" ; oboInOwl:id "HP:0006637" ; a owl:Class ; rdfs:label "Sternal punctate calcifications" ; rdfs:subClassOf obo:HP_0000766, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0006638 obo:IAO_0000115 "Developmental defect resulting in congenital absence of the middle portion of the clavicle." ; oboInOwl:hasDbXref "UMLS:C1844529" ; oboInOwl:hasExactSynonym "Missing middle part of collarbone" ; oboInOwl:id "HP:0006638" ; a owl:Class ; rdfs:label "Midclavicular aplasia" ; rdfs:subClassOf obo:HP_0006710 . obo:HP_0006640 obo:IAO_0000115 "More than one fracture of the ribs." ; oboInOwl:hasDbXref "SNOMEDCT_US:1261007", "UMLS:C0272567" ; oboInOwl:hasExactSynonym "Multiple rib fractures" ; oboInOwl:id "HP:0006640" ; a owl:Class ; rdfs:label "Multiple rib fractures" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002757 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006641 oboInOwl:hasDbXref "UMLS:C4025012" ; oboInOwl:hasExactSynonym "Prominent floating ribs" ; oboInOwl:id "HP:0006641" ; a owl:Class ; rdfs:label "Prominent floating ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002239 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006642 oboInOwl:hasDbXref "UMLS:C1865241" ; oboInOwl:hasExactSynonym "Large sternal ossification centres" ; oboInOwl:id "HP:0006642" ; a owl:Class ; rdfs:label "Large sternal ossification centers" ; rdfs:subClassOf obo:HP_0011863 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006643 oboInOwl:hasDbXref "UMLS:C1859376" ; oboInOwl:hasExactSynonym "Fused sternal ossification centres" ; oboInOwl:id "HP:0006643" ; a owl:Class ; rdfs:label "Fused sternal ossification centers" ; rdfs:subClassOf obo:HP_0011863 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010355 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0010355 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006644 oboInOwl:hasDbXref "UMLS:C1406921" ; oboInOwl:id "HP:0006644" ; a owl:Class ; rdfs:label "Thoracic dysplasia" ; rdfs:subClassOf obo:HP_0001547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006645 obo:IAO_0000115 "Abnormally reduced diameter (cross section) of the clavicles." ; oboInOwl:hasDbXref "SNOMEDCT_US:298764003", "UMLS:C0575535" ; oboInOwl:hasExactSynonym "Thin collarbone" ; oboInOwl:id "HP:0006645" ; a owl:Class ; rdfs:label "Thin clavicles" ; rdfs:subClassOf obo:HP_0000889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006646 obo:IAO_0000115 "Calcification of the costal cartilages, which are bars of hyaline cartilage found at the anterior ends of the ribs which serve to prolong the ribs forward and contribute to the elasticity of the walls of the thorax." ; oboInOwl:hasAlternativeId "HP:0006662" ; oboInOwl:hasDbXref "UMLS:C1855608" ; oboInOwl:hasExactSynonym "Cartilaginous ossification of rib" ; oboInOwl:id "HP:0006646" ; a owl:Class ; rdfs:label "Costal cartilage calcification" ; rdfs:subClassOf obo:HP_0012306, obo:HP_0100593 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006647 oboInOwl:hasDbXref "UMLS:C4025011" ; oboInOwl:id "HP:0006647" ; a owl:Class ; rdfs:label "Congenital microthorax" ; rdfs:subClassOf obo:HP_0005257 . obo:HP_0006649 obo:IAO_0000115 "Chest wall pain in the area of the costochondral junctions." ; oboInOwl:hasDbXref "UMLS:C4021587" ; oboInOwl:hasExactSynonym "Costochondral junction pain" ; oboInOwl:id "HP:0006649" ; a owl:Class ; rdfs:comment "Costochondral pain is in the differential diagnosis of chest pain, being a relatively benign cause compared to myocardial ischemia. Costochondral pain can be caused by costochondritis." ; rdfs:label "Costochondral pain" ; rdfs:subClassOf obo:HP_0000919, obo:HP_0012531 . obo:HP_0006650 oboInOwl:hasDbXref "UMLS:C1834383" ; oboInOwl:hasExactSynonym "Thickening of the lateral border of the shoulder blade" ; oboInOwl:id "HP:0006650" ; a owl:Class ; rdfs:label "Thickening of the lateral border of the scapula" ; rdfs:subClassOf obo:HP_0000782 . obo:HP_0006655 oboInOwl:hasDbXref "UMLS:C1968999" ; oboInOwl:id "HP:0006655" ; a owl:Class ; rdfs:label "Rib segmentation abnormalities" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0006657 oboInOwl:hasAlternativeId "HP:0006614", "HP:0006653" ; oboInOwl:hasDbXref "UMLS:C1834386" ; oboInOwl:hasExactSynonym "Hypoplastic first rib", "Hypoplastic first ribs", "Small first rib", "Underdeveloped first rib" ; oboInOwl:id "HP:0006657" ; a owl:Class ; rdfs:label "Hypoplasia of first ribs" ; rdfs:subClassOf obo:HP_0000773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006659 oboInOwl:hasDbXref "UMLS:C1862491" ; oboInOwl:hasExactSynonym "Internally rotated shoulders" ; oboInOwl:id "HP:0006659" ; a owl:Class ; rdfs:label "Internally rotated shoulders" ; rdfs:subClassOf obo:HP_0003043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002155 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006660 obo:IAO_0000115 "Absence of the clavicles as a developmental defect." ; oboInOwl:hasDbXref "UMLS:C1857665" ; oboInOwl:hasExactSynonym "Absent clavicles", "Absent collarbone", "Aplastic clavicles" ; oboInOwl:id "HP:0006660" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplastic clavicle" ; rdfs:subClassOf obo:HP_0006710 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006665 obo:IAO_0000115 "An abnormal morphology of the ribs consisting of shorted, abnormally curved ribs. On posteroanterior chest radiography, the ribs show a curvature resembling that of a coat hanger (clothes hanger)." ; oboInOwl:hasDbXref "UMLS:C4025010" ; oboInOwl:hasExactSynonym "Coat hanger sign of ribs" ; oboInOwl:id "HP:0006665" ; a owl:Class ; rdfs:comment "The coat hanger abnormality of the ribs is said to be a useful diagnostic marker of paternal uniparental disomy of chromosome 14." ; rdfs:label "Coat hanger sign of ribs" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0006668 oboInOwl:hasDbXref "UMLS:C1859361" ; oboInOwl:hasExactSynonym "Small twelfth rib", "Underdeveloped twelfth rib" ; oboInOwl:id "HP:0006668" ; a owl:Class ; rdfs:label "Twelfth rib hypoplasia" ; rdfs:subClassOf obo:HP_0000773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004611 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006670 oboInOwl:hasDbXref "UMLS:C4025009" ; oboInOwl:id "HP:0006670" ; a owl:Class ; rdfs:label "Impaired myocardial contractility" ; rdfs:subClassOf obo:HP_0006673 . obo:HP_0006671 oboInOwl:hasDbXref "SNOMEDCT_US:195069001", "UMLS:C0030587" ; oboInOwl:id "HP:0006671" ; a owl:Class ; rdfs:label "Paroxysmal atrial tachycardia" ; rdfs:subClassOf obo:HP_0004763 . obo:HP_0006673 oboInOwl:hasDbXref "UMLS:C4025008" ; oboInOwl:id "HP:0006673" ; a owl:Class ; rdfs:label "Reduced systolic function" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0006677 obo:IAO_0000115 "Increased time for the complex comprised of the Q wave, R wave, and S wave as measured by the electrocardiogram (EKG).. In adults, normal values are 0.06 - 0.10 sec." ; oboInOwl:hasDbXref "SNOMEDCT_US:991002", "UMLS:C0235475" ; oboInOwl:hasExactSynonym "Intraventricular conduction delay", "Prolonged QRS complex on EKG", "QRS widening" ; oboInOwl:id "HP:0006677" ; a owl:Class ; rdfs:label "Prolonged QRS complex" ; rdfs:subClassOf obo:HP_0025074 . obo:HP_0006679 obo:IAO_0000115 "Inflammation of the coronary arteries involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells." ; oboInOwl:hasDbXref "UMLS:C4025007" ; oboInOwl:id "HP:0006679" ; a owl:Class ; rdfs:comment "A granuloma is a compact (organized) collection of mature mononuclear phagocytes (macrophages and/or epithelioid cells) which may or may not be accompanied by accessory features such as necrosis or the infiltration of other inflammatory leukocytes (Adams DO. The granulomatous inflammatory response. Am J Pathol 1976:84:163-192)." ; rdfs:label "Granulomatous coronary arteritis" ; rdfs:subClassOf obo:HP_0006704, obo:HP_0012089 . obo:HP_0006681 oboInOwl:hasDbXref "UMLS:C4025006" ; oboInOwl:id "HP:0006681" ; a owl:Class ; rdfs:label "Absent atrioventricular node" ; rdfs:subClassOf obo:HP_0001678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002352 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006682 obo:IAO_0000115 "Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node." ; oboInOwl:hasAlternativeId "HP:0006678" ; oboInOwl:hasDbXref "MSH:D018879", "SNOMEDCT_US:17338001", "SNOMEDCT_US:251175005", "UMLS:C0151636" ; oboInOwl:hasExactSynonym "Extra heart beat", "Premature ventricular beat", "Premature ventricular contractions", "Ventricular ectopics", "Ventricular extrasystoles", "Ventricular premature beat" ; oboInOwl:hasRelatedSynonym "Missed heartbeat", "Skipped heartbeat" ; oboInOwl:id "HP:0006682" ; a owl:Class ; rdfs:comment "A premature ventricular contraction may be perceived as a skipped beat or as palpitations. Although they may cause symptoms such as palpitations or dizziness, incidental PVCs are generally considered benign. Highly frequent PVCs, however, can have detrimental effects on the left ventricular function over time and may cause or worsen heart failure." ; rdfs:label "Premature ventricular contraction" ; rdfs:subClassOf obo:HP_0004308 . obo:HP_0006683 obo:IAO_0000115 "An abnormality of filling of a ventricle with blood during diastole." ; oboInOwl:hasDbXref "UMLS:C4025005" ; oboInOwl:id "HP:0006683" ; a owl:Class ; rdfs:comment "Two diastolic properties, the rate of ventricular relaxation and the ventricular compliance are especially important determinants of ventricular filling." ; rdfs:label "Abnormal ventricular filling" ; rdfs:subClassOf obo:HP_0030872 . obo:HP_0006684 obo:IAO_0000115 "A form of ventricular preexcitation due to the presence of multiple accessory pathways for cardiac conduction." ; oboInOwl:hasDbXref "UMLS:C4025004" ; oboInOwl:id "HP:0006684" ; a owl:Class ; rdfs:label "Ventricular preexcitation with multiple accessory pathways" ; rdfs:subClassOf obo:HP_0004309 . obo:HP_0006685 obo:IAO_0000115 "The presence of excessive connective tissue in the endocardium." ; oboInOwl:hasAlternativeId "HP:0005169" ; oboInOwl:hasDbXref "MSH:D004719", "SNOMEDCT_US:398716006", "UMLS:C0553980" ; oboInOwl:hasExactSynonym "Endomyocardial fibrosis" ; oboInOwl:id "HP:0006685" ; a owl:Class ; rdfs:label "Endocardial fibrosis" ; rdfs:subClassOf obo:HP_0004306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006687 obo:IAO_0000115 "Abnormal tortuous (i.e., twisted) form of the aorta." ; oboInOwl:hasDbXref "UMLS:C4025003" ; oboInOwl:id "HP:0006687" ; a owl:Class ; rdfs:label "Aortic tortuosity" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0006688 oboInOwl:hasDbXref "MSH:D013614", "SNOMEDCT_US:12026006", "UMLS:C0039236" ; oboInOwl:id "HP:0006688" ; a owl:Class ; rdfs:label "Paroxysmal tachycardia" ; rdfs:subClassOf obo:HP_0001649 . obo:HP_0006689 obo:IAO_0000115 "A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T02:57:48Z" ; oboInOwl:hasDbXref "MSH:D004697", "SNOMEDCT_US:301183007", "UMLS:C0014121" ; oboInOwl:hasExactSynonym "Infective endocarditis" ; oboInOwl:id "HP:0006689" ; a owl:Class ; rdfs:label "Bacterial endocarditis" ; rdfs:subClassOf obo:HP_0100584 . obo:HP_0006690 obo:IAO_0000115 "Calcium deposition in the myocardium." ; oboInOwl:hasDbXref "Fyler:1889", "UMLS:C1096561" ; oboInOwl:hasExactSynonym "Calcified myocardium" ; oboInOwl:id "HP:0006690" ; a owl:Class ; rdfs:comment "Calcification affecting the muscle layer of the heart." ; rdfs:label "Myocardial calcification" ; rdfs:subClassOf obo:HP_0001713, obo:HP_0011915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006691 obo:IAO_0000115 "A benign tumor of connective tissue containing mucous or gelatinous material (myxoma) localized in the pumonic valve." ; oboInOwl:hasDbXref "UMLS:C4025002" ; oboInOwl:id "HP:0006691" ; a owl:Class ; rdfs:label "Pulmonic valve myxoma" ; rdfs:subClassOf obo:HP_0001641 . obo:HP_0006692 obo:IAO_0000115 "Abnormally short chordae tendineae of the tricuspid valve." ; oboInOwl:hasDbXref "UMLS:C4025001" ; oboInOwl:id "HP:0006692" ; a owl:Class ; rdfs:comment "The chordae tendineae connect the papillary muscles to the tricuspid valve and the mitral valve." ; rdfs:label "Short chordae tendineae of the tricuspid valve" ; rdfs:subClassOf obo:HP_0031442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014852 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006693 obo:IAO_0000115 "Steatosis in the myocardium." ; oboInOwl:hasDbXref "UMLS:C4025000" ; oboInOwl:id "HP:0006693" ; a owl:Class ; rdfs:label "Myocardial steatosis" ; rdfs:subClassOf obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002349 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006694 oboInOwl:hasDbXref "UMLS:C4024999" ; oboInOwl:id "HP:0006694" ; a owl:Class ; rdfs:label "Early progressive calcific cardiac valvular disease" ; rdfs:subClassOf obo:HP_0005146 . obo:HP_0006695 obo:IAO_0000115 "A defect of the atrioventricular septum of the heart." ; oboInOwl:hasAlternativeId "HP:0005139", "HP:0005298", "HP:0010439" ; oboInOwl:hasBroadSynonym "Hole in center of heart", "Hole in centre of heart" ; oboInOwl:hasDbXref "Fyler:0606", "Fyler:1100", "Fyler:606", "MSH:C562831", "MSH:D004694", "SNOMEDCT_US:15459006", "UMLS:C0014116", "UMLS:C1389016" ; oboInOwl:hasExactSynonym "Atrioventricular septal defect", "Endocardial cushion defect" ; oboInOwl:id "HP:0006695" ; a owl:Class ; rdfs:comment "During atrioventricular valvuloseptal morphogenesis, the endocardial cushions expand as they are infiltrated by extracellular matrix secreted from the surrounding myocardium. The cushions then fuse and are remodeled to form the atrioventricular valves and septa. Failure of this process results in AVSD, with the degree of severity dependent on the stage at which the developmental failure occurs. AVSD are a spectrum of cardiac malformations that result in a persistent common atrioventricular canal." ; rdfs:label "Atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0001671 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002087 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006696 oboInOwl:hasDbXref "UMLS:C4024998" ; oboInOwl:id "HP:0006696" ; a owl:Class ; rdfs:label "Polymorphic and polytopic ventricular extrasystoles" ; rdfs:subClassOf obo:HP_0006682 . obo:HP_0006698 obo:IAO_0000115 "A localized outpouching of ventricular cavity that is generally associated with dyskinesia and paradoxical expansion during systole." ; oboInOwl:hasDbXref "SNOMEDCT_US:90539001", "UMLS:C0392464" ; oboInOwl:hasNarrowSynonym "Ventricular aneurysm" ; oboInOwl:id "HP:0006698" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation. Ventricular aneurysms may have rim of calcium in the affected regions of the ventricular wall (which can become fibrotic). Thromboembolism is a potential complication. Ventricular aneurysms can be diagnosed by ventriculography." ; rdfs:label "Dilatation of the ventricular cavity" ; rdfs:subClassOf obo:HP_0001713, obo:HP_0002617 . obo:HP_0006699 obo:IAO_0000115 "A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites." ; oboInOwl:hasDbXref "MSH:D018880", "SNOMEDCT_US:284470004", "SNOMEDCT_US:287057009", "SNOMEDCT_US:406461004", "SNOMEDCT_US:63593006", "UMLS:C0033036" ; oboInOwl:hasExactSynonym "Atrial ectopic beats", "Atrial premature complex", "Ectopic supraventricular rhythms", "PACs", "Premature supraventricular beats" ; oboInOwl:id "HP:0006699" ; a owl:Class ; rdfs:label "Premature atrial contractions" ; rdfs:subClassOf obo:HP_0005115 . obo:HP_0006702 obo:IAO_0000115 "Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery." ; oboInOwl:hasDbXref "MSH:C565153", "UMLS:C1852540" ; oboInOwl:id "HP:0006702" ; a owl:Class ; rdfs:label "Coronary artery dissection" ; rdfs:subClassOf obo:HP_0006704 . obo:HP_0006703 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:17:00Z" ; oboInOwl:hasDbXref "UMLS:C4024996" ; oboInOwl:hasExactSynonym "Absent/small lungs", "Absent/underdeveloped lungs" ; oboInOwl:id "HP:0006703" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the lungs" ; rdfs:subClassOf obo:HP_4000059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006704 obo:IAO_0000115 "Any structural abnormality of the coronary arteries." ; dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:33:00Z" ; oboInOwl:hasDbXref "Fyler:3100", "SNOMEDCT_US:28574005", "UMLS:C0158623" ; oboInOwl:id "HP:0006704" ; a owl:Class ; rdfs:label "Abnormal coronary artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001621 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006705 obo:IAO_0000115 "An abnormality of an atrioventricular valve." ; dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:34:00Z" ; oboInOwl:hasAlternativeId "HP:0006675" ; oboInOwl:hasDbXref "UMLS:C4024995" ; oboInOwl:hasExactSynonym "Abnormality of the atrioventricular valves" ; oboInOwl:id "HP:0006705" ; a owl:Class ; rdfs:label "Abnormal atrioventricular valve morphology" ; rdfs:subClassOf obo:HP_0001654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006706 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:37:00Z" ; oboInOwl:hasDbXref "MSH:C536330", "SNOMEDCT_US:72925005", "UMLS:C0158683" ; oboInOwl:id "HP:0006706" ; a owl:Class ; rdfs:label "Cystic liver disease" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0006707 obo:IAO_0000115 "An abnormality of the hepatic vasculature." ; dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:41:00Z" ; oboInOwl:hasDbXref "UMLS:C4024994" ; oboInOwl:hasExactSynonym "Abnormality of liver blood vessels", "Abnormality of the liver vasculature" ; oboInOwl:id "HP:0006707" ; a owl:Class ; rdfs:label "Abnormality of the hepatic vasculature" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006877 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006709 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:51:00Z" ; oboInOwl:hasAlternativeId "HP:0006602", "HP:0006669" ; oboInOwl:hasDbXref "UMLS:C3150086" ; oboInOwl:hasExactSynonym "Absent/rudimentary nipples", "Absent/small nipples", "Absent/underdeveloped nipples", "Nipples absent or rudimentary" ; oboInOwl:id "HP:0006709" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the nipples" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002030 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006710 obo:IAO_0000115 "Absence or underdevelopment of the clavicles (collar bones)." ; dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:53:00Z" ; oboInOwl:hasDbXref "UMLS:C4024993" ; oboInOwl:hasExactSynonym "Absent/small collarbone", "Absent/underdeveloped collarbone" ; oboInOwl:id "HP:0006710" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the clavicles" ; rdfs:subClassOf obo:HP_0000889, obo:HP_0006711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006711 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:53:00Z" ; oboInOwl:hasDbXref "UMLS:C4024992" ; oboInOwl:hasExactSynonym "Absent/small outermost thorax bone", "Absent/underdeveloped thorax bone" ; oboInOwl:id "HP:0006711" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving bones of the thorax" ; rdfs:subClassOf obo:HP_0000765, obo:HP_0009122 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014477 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006712 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:54:00Z" ; oboInOwl:hasAlternativeId "HP:0006636" ; oboInOwl:hasDbXref "UMLS:C1847363" ; oboInOwl:hasExactSynonym "Absent/small ribs", "Absent/underdeveloped ribs", "Hypoplastic or missing ribs" ; oboInOwl:id "HP:0006712" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the ribs" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0006711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006713 dcterms:creator ; oboInOwl:creation_date "2008-03-29T03:58:00Z" ; oboInOwl:hasDbXref "UMLS:C4024991" ; oboInOwl:hasExactSynonym "Absent/small shoulder blade", "Absent/underdeveloped shoulder blade" ; oboInOwl:id "HP:0006713" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the scapulae" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0006711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006849 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006714 dcterms:creator ; oboInOwl:creation_date "2008-03-29T04:01:00Z" ; oboInOwl:hasDbXref "UMLS:C4024990" ; oboInOwl:hasExactSynonym "Absent/small sternum", "Absent/underdeveloped sternum" ; oboInOwl:id "HP:0006714" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the sternum" ; rdfs:subClassOf obo:HP_0000766, obo:HP_0006711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006715 oboInOwl:hasAlternativeId "HP:0002892" ; oboInOwl:hasDbXref "UMLS:C1866555" ; oboInOwl:hasExactSynonym "Tympanic nerve tumor", "Tympanic nerve tumors", "Tympanic nerve tumour", "Tympanic nerve tumours" ; oboInOwl:id "HP:0006715" ; a owl:Class ; rdfs:label "Glomus tympanicum paraganglioma" ; rdfs:subClassOf obo:HP_0002864 . obo:HP_0006716 oboInOwl:hasDbXref "UMLS:C4024989" ; oboInOwl:id "HP:0006716" ; a owl:Class ; rdfs:label "Hereditary nonpolyposis colorectal carcinoma" ; rdfs:subClassOf obo:HP_0002672, obo:HP_0100834 . obo:HP_0006717 oboInOwl:hasDbXref "SNOMEDCT_US:254764001", "UMLS:C3489398" ; oboInOwl:id "HP:0006717" ; a owl:Class ; rdfs:label "Peripheral neuroepithelioma" ; rdfs:subClassOf obo:HP_0100007 . obo:HP_0006719 oboInOwl:hasDbXref "SNOMEDCT_US:92118007", "UMLS:C0497538" ; oboInOwl:hasExactSynonym "Benign GI tract tumors", "Benign GI tract tumours", "Benign gastrointestinal tract tumours", "Non-cancerous GI tumors", "Non-cancerous GI tumours" ; oboInOwl:id "HP:0006719" ; a owl:Class ; rdfs:label "Benign gastrointestinal tract tumors" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0006721 obo:IAO_0000115 "A form of acute leukemia characterized by excess lympoblasts." ; oboInOwl:hasAlternativeId "HP:0004803", "HP:0005555" ; oboInOwl:hasDbXref "SNOMEDCT_US:128822004", "SNOMEDCT_US:91857003", "UMLS:C0023449" ; oboInOwl:hasExactSynonym "Acute lymphatic leukaemia", "Acute lymphatic leukemia", "Acute lymphoblastic leukaemia", "Acute lymphocytic leukaemia", "Acute lymphocytic leukemia", "Acute lymphoid leukaemia", "Acute lymphoid leukemia" ; oboInOwl:id "HP:0006721" ; a owl:Class ; rdfs:label "Acute lymphoblastic leukemia" ; rdfs:subClassOf obo:HP_0002488 . obo:HP_0006722 oboInOwl:hasDbXref "UMLS:C1868072" ; oboInOwl:id "HP:0006722" ; a owl:Class ; rdfs:label "Small intestine carcinoid" ; rdfs:subClassOf obo:HP_0100570, obo:HP_0100833 . obo:HP_0006723 oboInOwl:hasDbXref "UMLS:C4024988" ; oboInOwl:id "HP:0006723" ; a owl:Class ; rdfs:label "Intestinal carcinoid" ; rdfs:subClassOf obo:HP_0007378, obo:HP_0100570 . obo:HP_0006725 obo:IAO_0000115 "The presence of an adenocarcinoma of the pancreas." ; oboInOwl:hasDbXref "NCIT:C2852", "SNOMEDCT_US:700423003", "UMLS:C0281361" ; oboInOwl:id "HP:0006725" ; a owl:Class ; rdfs:label "Pancreatic adenocarcinoma" ; rdfs:subClassOf obo:HP_0002894 . obo:HP_0006727 obo:IAO_0000115 "Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females." ; oboInOwl:hasDbXref "MSH:D054218", "SNOMEDCT_US:128824003", "SNOMEDCT_US:277575008", "UMLS:C1961099" ; oboInOwl:id "HP:0006727" ; a owl:Class ; rdfs:label "T-cell acute lymphoblastic leukemias" ; rdfs:subClassOf obo:HP_0006721 . obo:HP_0006729 oboInOwl:hasDbXref "NCIT:C3308", "UMLS:C4024987" ; oboInOwl:id "HP:0006729" ; a owl:Class ; rdfs:label "Retroperitoneal chemodectomas" ; rdfs:subClassOf obo:HP_0011793 . obo:HP_0006731 obo:IAO_0000115 "The presence of an follicular adenocarcinoma of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D018263", "NCIT:C8054", "SNOMEDCT_US:255028004", "SNOMEDCT_US:28173006", "SNOMEDCT_US:5257006", "UMLS:C0206682" ; oboInOwl:id "HP:0006731" ; a owl:Class ; rdfs:label "Follicular thyroid carcinoma" ; rdfs:subClassOf obo:HP_0002890 . obo:HP_0006732 obo:IAO_0000115 "A type of papillary renal cell carcinoma in which the papillae are covered by large eosinophilic cells with pleomorphic nuclei, prominent nucleoli, and nuclear pseudostratification." ; oboInOwl:hasDbXref "UMLS:C1336840" ; oboInOwl:id "HP:0006732" ; a owl:Class ; rdfs:comment "Papillary renal cell carcinoma type 2 is a common feature of hereditary leiomyomatosis and renal cell cancer; HLRCC (OMIM 150800)." ; rdfs:label "Papillary renal cell carcinoma type 2" ; rdfs:subClassOf obo:HP_0006766 . obo:HP_0006733 obo:IAO_0000115 "A rare subtype of acute myeloid leukemia evolving from primitive megakaryoblasts." ; oboInOwl:hasDbXref "MSH:D015470", "SNOMEDCT_US:17788007", "SNOMEDCT_US:413443009", "SNOMEDCT_US:91861009", "UMLS:C0023467" ; oboInOwl:hasExactSynonym "AMegL", "Acute megakaryocytic leukaemia" ; oboInOwl:id "HP:0006733" ; a owl:Class ; rdfs:label "Acute megakaryocytic leukemia" ; rdfs:subClassOf obo:HP_0002488 . obo:HP_0006735 obo:IAO_0000115 "The presence of an adenoma in the cortex of the kidney." ; oboInOwl:hasDbXref "NCIT:C2855", "SNOMEDCT_US:254919009", "UMLS:C0346253" ; oboInOwl:hasExactSynonym "Kidney cortical adenoma" ; oboInOwl:id "HP:0006735" ; a owl:Class ; rdfs:label "Renal cortical adenoma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0006737 obo:IAO_0000115 "Pheochromocytoma not originating from the adrenal medulla but from another source such as from chromaffin cells in or about sympathetic ganglia." ; oboInOwl:hasAlternativeId "HP:0006764" ; oboInOwl:hasDbXref "MSH:D010673", "UMLS:C1257877" ; oboInOwl:hasExactSynonym "Pheochromocytoma, extraadrenal" ; oboInOwl:id "HP:0006737" ; a owl:Class ; rdfs:label "Extraadrenal pheochromocytoma" ; rdfs:subClassOf obo:HP_0002666 . obo:HP_0006739 obo:IAO_0000115 "Squamous cell carcinoma of the skin is a malignant tumor of squamous epithelium." ; oboInOwl:hasAlternativeId "HP:0007614" ; oboInOwl:hasDbXref "SNOMEDCT_US:254651007", "UMLS:C0553723" ; oboInOwl:hasExactSynonym "Squamous skin carcinoma" ; oboInOwl:id "HP:0006739" ; a owl:Class ; rdfs:label "Squamous cell carcinoma of the skin" ; rdfs:subClassOf obo:HP_0002860 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002860 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006740 obo:IAO_0000115 "The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell." ; oboInOwl:hasDbXref "NCIT:C2930", "SNOMEDCT_US:255109008", "UMLS:C0279680" ; oboInOwl:hasExactSynonym "Transitional cell bladder carcinoma" ; oboInOwl:id "HP:0006740" ; a owl:Class ; rdfs:label "Transitional cell carcinoma of the bladder" ; rdfs:subClassOf obo:HP_0002862 . obo:HP_0006742 oboInOwl:hasDbXref "UMLS:C4024986" ; oboInOwl:id "HP:0006742" ; a owl:Class ; rdfs:label "Congenital neuroblastoma" ; rdfs:subClassOf obo:HP_0003006 . obo:HP_0006743 oboInOwl:hasDbXref "MSH:D018233", "NCIT:C8971", "SNOMEDCT_US:14269005", "SNOMEDCT_US:404051002", "UMLS:C0206656" ; oboInOwl:id "HP:0006743" ; a owl:Class ; rdfs:label "Embryonal rhabdomyosarcoma" ; rdfs:subClassOf obo:HP_0002859, obo:HP_0002898 . obo:HP_0006744 obo:IAO_0000115 "A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone." ; oboInOwl:hasAlternativeId "HP:0002889", "HP:0006759" ; oboInOwl:hasDbXref "MSH:D018268", "NCIT:C2916", "SNOMEDCT_US:2227007", "SNOMEDCT_US:255035007", "UMLS:C0206686" ; oboInOwl:hasExactSynonym "Adrenal carcinoma", "Adrenal gland carinoma" ; oboInOwl:id "HP:0006744" ; a owl:Class ; rdfs:label "Adrenocortical carcinoma" ; rdfs:subClassOf obo:HP_0100641 . obo:HP_0006747 oboInOwl:hasDbXref "MSH:D018305", "SNOMEDCT_US:116381000119105", "SNOMEDCT_US:69515008", "UMLS:C0206718" ; oboInOwl:id "HP:0006747" ; a owl:Class ; rdfs:label "Ganglioneuroblastoma" ; rdfs:subClassOf obo:HP_0003006 . obo:HP_0006748 obo:IAO_0000115 "Pheochromocytoma originating from the adrenal medulla." ; oboInOwl:hasAlternativeId "HP:0006752" ; oboInOwl:hasDbXref "MSH:D010673", "NCIT:C3326", "SNOMEDCT_US:302835009", "SNOMEDCT_US:399343007", "SNOMEDCT_US:85583005", "UMLS:C0031511" ; oboInOwl:hasExactSynonym "Pheochromocytoma, adrenal", "Pheochromocytomas, adrenal" ; oboInOwl:id "HP:0006748" ; a owl:Class ; rdfs:label "Adrenal pheochromocytoma" ; rdfs:subClassOf obo:HP_0002666, obo:HP_0100642 . obo:HP_0006749 oboInOwl:hasDbXref "MSH:D005770", "SNOMEDCT_US:428905002", "UMLS:C0685938" ; oboInOwl:hasExactSynonym "Malignant GI tract tumors", "Malignant GI tract tumours", "Malignant gastrointestinal tract tumours" ; oboInOwl:id "HP:0006749" ; a owl:Class ; rdfs:label "Malignant gastrointestinal tract tumors" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0006751 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized adjacent to the spine." ; oboInOwl:hasDbXref "UMLS:C4024985" ; oboInOwl:hasExactSynonym "Paraspinal neurofibromas" ; oboInOwl:id "HP:0006751" ; a owl:Class ; rdfs:label "Paraspinal neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0006753 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the stomach." ; oboInOwl:hasDbXref "MSH:D013274", "NCIT:C3262", "SNOMEDCT_US:126824007", "UMLS:C0038356", "UMLS:C4020813" ; oboInOwl:hasExactSynonym "Stomach tumor", "Stomach tumour" ; oboInOwl:hasRelatedSynonym "Neoplasia of the stomach" ; oboInOwl:id "HP:0006753" ; a owl:Class ; rdfs:label "Neoplasm of the stomach" ; rdfs:subClassOf obo:HP_0002577, obo:HP_0007378 . obo:HP_0006755 obo:IAO_0000115 "The presence of leiomyosarcoma of the skin." ; oboInOwl:hasDbXref "NCIT:C3158", "SNOMEDCT_US:254771006", "UMLS:C0346067" ; oboInOwl:id "HP:0006755" ; a owl:Class ; rdfs:label "Cutaneous leiomyosarcoma" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0100243 . obo:HP_0006756 oboInOwl:hasDbXref "UMLS:C4024984" ; oboInOwl:id "HP:0006756" ; a owl:Class ; rdfs:label "Diffuse leiomyomatosis" ; rdfs:subClassOf obo:HP_0031459 . obo:HP_0006758 obo:IAO_0000115 "The presence of a malignant neoplasm of the genital system." ; oboInOwl:hasDbXref "UMLS:C1834728" ; oboInOwl:hasExactSynonym "Malignant GU tract tumor", "Malignant GU tract tumour", "Malignant genitourinary tract tumour" ; oboInOwl:id "HP:0006758" ; a owl:Class ; rdfs:label "Malignant genitourinary tract tumor" ; rdfs:subClassOf obo:HP_0007379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0007379 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002097 ] ) ] ] . obo:HP_0006762 obo:IAO_0000115 "The presence of a carcinoma in the renal pelvis." ; oboInOwl:hasDbXref "NCIT:C2916", "UMLS:C4024983" ; oboInOwl:id "HP:0006762" ; a owl:Class ; rdfs:label "Renal pelvic carcinoma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0006763 oboInOwl:hasDbXref "UMLS:C4024982" ; oboInOwl:id "HP:0006763" ; a owl:Class ; rdfs:label "Anal canal squamous carcinoma" ; rdfs:subClassOf obo:HP_0030437 . obo:HP_0006765 obo:IAO_0000115 "A slowly growing malignant neoplasm derived from cartilage cells." ; oboInOwl:hasDbXref "MSH:D002813", "NCIT:C2946", "SNOMEDCT_US:14990007", "SNOMEDCT_US:443520009", "UMLS:C0008479" ; oboInOwl:id "HP:0006765" ; a owl:Class ; rdfs:label "Chondrosarcoma" ; rdfs:subClassOf obo:HP_0010622, obo:HP_0100242 . obo:HP_0006766 obo:IAO_0000115 "The presence of renal cell carcinoma in the renal papilla." ; oboInOwl:hasAlternativeId "HP:0006776" ; oboInOwl:hasDbXref "MSH:D002292", "NCIT:C2916", "UMLS:C1306837" ; oboInOwl:id "HP:0006766" ; a owl:Class ; rdfs:label "Papillary renal cell carcinoma" ; rdfs:subClassOf obo:HP_0005584 . obo:HP_0006767 obo:IAO_0000115 "A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women." ; oboInOwl:hasDbXref "MSH:D015175", "SNOMEDCT_US:134209002", "SNOMEDCT_US:34337008", "UMLS:C0033375" ; oboInOwl:hasExactSynonym "Pituitary prolactinoma", "Prolactin-secreting pituitary adenoma" ; oboInOwl:id "HP:0006767" ; a owl:Class ; rdfs:label "Pituitary prolactin cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0006768 oboInOwl:hasDbXref "UMLS:C4024981" ; oboInOwl:hasExactSynonym "Localised neuroblastoma" ; oboInOwl:id "HP:0006768" ; a owl:Class ; rdfs:label "Localized neuroblastoma" ; rdfs:subClassOf obo:HP_0003006 . obo:HP_0006769 oboInOwl:hasDbXref "UMLS:C1834421" ; oboInOwl:hasExactSynonym "Myxoid subcutaneous tumours" ; oboInOwl:id "HP:0006769" ; a owl:Class ; rdfs:label "Myxoid subcutaneous tumors" ; rdfs:subClassOf obo:HP_0008069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_429 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011818 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006770 obo:IAO_0000115 "A subtype of renal cell carcinoma thought to originate from mature renal tubular cells in the proximal tubule of the nehpron." ; oboInOwl:hasDbXref "MSH:D002292", "SNOMEDCT_US:188251003", "SNOMEDCT_US:254915003", "SNOMEDCT_US:41607009", "UMLS:C0279702" ; oboInOwl:hasExactSynonym "Nonpapillary renal cell carcinoma" ; oboInOwl:id "HP:0006770" ; a owl:Class ; rdfs:label "Clear cell renal cell carcinoma" ; rdfs:subClassOf obo:HP_0005584 . obo:HP_0006771 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the duodenum." ; oboInOwl:hasDbXref "MSH:D004379", "NCIT:C2852", "SNOMEDCT_US:254570009", "SNOMEDCT_US:408644002", "UMLS:C0278804", "UMLS:C0541912" ; oboInOwl:hasRelatedSynonym "Duodenal cancer" ; a owl:Class ; rdfs:label "Duodenal adenocarcinoma" ; rdfs:subClassOf obo:HP_0040274 . obo:HP_0006772 obo:IAO_0000115 "A benign renal neoplasm composed of fat, vascular, and smooth muscle elements." ; oboInOwl:hasAlternativeId "HP:0100873" ; oboInOwl:hasDbXref "NCIT:C3734", "SNOMEDCT_US:254921004", "UMLS:C0241961" ; oboInOwl:hasExactSynonym "Angiomyolipoma", "Kidney angiomyolipoma" ; oboInOwl:id "HP:0006772" ; a owl:Class ; rdfs:comment "Angiomyolipoma is a benign renal neoplasm composed of fat, vascular, and smooth muscle elements." ; rdfs:label "Renal angiomyolipoma" ; rdfs:subClassOf obo:HP_0008696 . obo:HP_0006773 oboInOwl:hasDbXref "NCIT:C3733", "UMLS:C4024980" ; oboInOwl:id "HP:0006773" ; a owl:Class ; rdfs:label "Cutaneous angiolipomas" ; rdfs:subClassOf obo:HP_0001012, obo:HP_0008069 . obo:HP_0006774 obo:IAO_0000115 "The presence of a papillary adenocarcinoma of the ovary." ; oboInOwl:hasDbXref "NCIT:C2853", "UMLS:C4024979" ; oboInOwl:id "HP:0006774" ; a owl:Class ; rdfs:label "Ovarian papillary adenocarcinoma" ; rdfs:subClassOf obo:HP_0100615 . obo:HP_0006775 obo:IAO_0000115 "A malignant plasma cell tumor growing within soft tissue or within the skeleton." ; oboInOwl:hasDbXref "MSH:D009101", "MSH:D010954", "SNOMEDCT_US:10639003", "SNOMEDCT_US:109989006", "SNOMEDCT_US:415112005", "SNOMEDCT_US:55921005", "UMLS:C0026764", "UMLS:C0032131" ; oboInOwl:hasRelatedSynonym "Kahler's disease", "Plasmocytoma" ; oboInOwl:id "HP:0006775" ; a owl:Class ; rdfs:label "Multiple myeloma" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0006778 obo:IAO_0000115 "A non-malignant neoplasm of the genitourinary system." ; oboInOwl:hasDbXref "UMLS:C3804991" ; oboInOwl:hasExactSynonym "Benign GU tract neoplasm", "Benign genitourinary tract tumor", "Benign genitourinary tract tumour" ; oboInOwl:id "HP:0006778" ; a owl:Class ; rdfs:label "Benign genitourinary tract neoplasm" ; rdfs:subClassOf obo:HP_0007379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0007379 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002096 ] ) ] ] . obo:HP_0006779 oboInOwl:hasDbXref "MSH:D018232", "NCIT:C3749", "SNOMEDCT_US:404053004", "SNOMEDCT_US:63449009", "UMLS:C0206655" ; oboInOwl:id "HP:0006779" ; a owl:Class ; rdfs:label "Alveolar rhabdomyosarcoma" ; rdfs:subClassOf obo:HP_0002859 . obo:HP_0006780 obo:IAO_0000115 "A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism." ; oboInOwl:hasDbXref "MSH:D010282", "NCIT:C2916", "SNOMEDCT_US:255037004", "SNOMEDCT_US:363481002", "UMLS:C0687150" ; oboInOwl:hasExactSynonym "Parathyroid Cancer" ; oboInOwl:id "HP:0006780" ; a owl:Class ; rdfs:label "Parathyroid carcinoma" ; rdfs:subClassOf obo:HP_0100733 . obo:HP_0006781 obo:IAO_0000115 "A kind of thyroid adenoma characterized by the presence of oxyphil cells." ; oboInOwl:hasDbXref "UMLS:C1336750" ; oboInOwl:id "HP:0006781" ; a owl:Class ; rdfs:comment "Oxyphil cells of thyroid, defined by the Cell Ontology as oncocytes located in the thyroid, are also known as Hurthle cells." ; rdfs:label "Hurthle cell thyroid adenoma" ; rdfs:subClassOf obo:HP_0000854 . obo:HP_0006782 oboInOwl:hasDbXref "MSH:C565054", "UMLS:C1851585" ; oboInOwl:id "HP:0006782" ; a owl:Class ; rdfs:label "Malignant eosinophil proliferation" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0006783 oboInOwl:hasDbXref "UMLS:C1848389" ; oboInOwl:id "HP:0006783" ; a owl:Class ; rdfs:label "Posterior pharyngeal cleft" ; rdfs:subClassOf obo:HP_0000600 . obo:HP_0006784 obo:IAO_0000115 "Underdevelopment of the paranasal sinuses." ; oboInOwl:hasBroadSynonym "Small paranasal sinus" ; oboInOwl:hasDbXref "UMLS:C2749161", "UMLS:C4280256", "UMLS:C4280441", "UMLS:C4280442" ; oboInOwl:hasExactSynonym "Decreased size of paranasal sinus", "Decreased volume of paranasal sinus", "Underdevelopment of paranasal sinus" ; oboInOwl:hasNarrowSynonym "Decreased growth of paranasal sinus", "Decreased pneumatization of paranasal sinus" ; oboInOwl:hasRelatedSynonym "Atelectasis of paranasal sinus", "Hypotrophic paranasal sinus" ; oboInOwl:id "HP:0006784" ; a owl:Class ; rdfs:label "Paranasal sinus hypoplasia" ; rdfs:subClassOf obo:HP_0005453 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001825 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006785 obo:IAO_0000115 "Muscular dystrophy affecting the muscles of the limb girdle (the hips and shoulders)." ; oboInOwl:hasAlternativeId "HP:0009066" ; oboInOwl:hasDbXref "MSH:D049288", "SNOMEDCT_US:93153005", "UMLS:C0686353" ; oboInOwl:hasExactSynonym "limb girdle muscular dystrophy" ; oboInOwl:id "HP:0006785" ; a owl:Class ; rdfs:label "Limb-girdle muscular dystrophy" ; rdfs:subClassOf obo:HP_0003560, obo:HP_0003797 . obo:HP_0006789 oboInOwl:hasDbXref "MSH:C538525", "UMLS:C1852373" ; oboInOwl:id "HP:0006789" ; a owl:Class ; rdfs:label "Mitochondrial encephalopathy" ; rdfs:subClassOf obo:HP_0001298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001298 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006790 oboInOwl:hasDbXref "UMLS:C1857934" ; oboInOwl:id "HP:0006790" ; a owl:Class ; rdfs:label "Cerebral cortex with spongiform changes" ; rdfs:subClassOf obo:HP_0002538 . obo:HP_0006794 oboInOwl:hasDbXref "UMLS:C1846133" ; oboInOwl:hasExactSynonym "Loss of ability to walk in first decade" ; oboInOwl:id "HP:0006794" ; a owl:Class ; rdfs:label "Loss of ability to walk in first decade" ; rdfs:subClassOf obo:HP_0002505 . obo:HP_0006799 oboInOwl:hasAlternativeId "HP:0007244" ; oboInOwl:hasDbXref "UMLS:C1837251" ; oboInOwl:hasExactSynonym "Cystic lesions in the basal ganglia" ; oboInOwl:id "HP:0006799" ; a owl:Class ; rdfs:label "Basal ganglia cysts" ; rdfs:subClassOf obo:HP_0002134, obo:HP_0010576 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006801 oboInOwl:hasAlternativeId "HP:0007259" ; oboInOwl:hasDbXref "UMLS:C1846176" ; oboInOwl:id "HP:0006801" ; a owl:Class ; rdfs:label "Hyperactive deep tendon reflexes" ; rdfs:subClassOf obo:HP_0001347 . obo:HP_0006802 obo:IAO_0000115 "Any anomaly of the anterior horn cell." ; oboInOwl:hasBroadSynonym "Abnormality of the anterior horn cell" ; oboInOwl:hasDbXref "MSH:D016472", "SNOMEDCT_US:85672005", "UMLS:C0154681", "UMLS:C4020812" ; oboInOwl:hasExactSynonym "Abnormality of the anterior horn cells", "Anomaly of the anterior horn cells", "Anterior horn cell disease" ; oboInOwl:id "HP:0006802" ; a owl:Class ; rdfs:comment "Anterior horn cells are efferent neurons that passes from the central nervous system or a ganglion toward or to a muscle. They conduct nerve impulses that lead to movement of muscles." ; rdfs:label "Abnormal anterior horn cell morphology" ; rdfs:subClassOf obo:HP_0000759, obo:HP_0002450 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0011001 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006803 oboInOwl:hasDbXref "UMLS:C4024978" ; oboInOwl:id "HP:0006803" ; a owl:Class ; rdfs:label "Vivid hallucinations" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0006808 obo:IAO_0000115 "Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system." ; oboInOwl:hasDbXref "UMLS:C2677328" ; oboInOwl:hasExactSynonym "Hypomyelination of the brain" ; oboInOwl:id "HP:0006808" ; a owl:Class ; rdfs:label "Cerebral hypomyelination" ; rdfs:subClassOf obo:HP_0003429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006812 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1836525" ; oboInOwl:id "HP:0006812" ; a owl:Class ; rdfs:label "White mater abnormalities in the posterior periventricular region" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0006813 obo:IAO_0000115 "A type of focal clonic seizure characterized by sustained rhythmic jerking rapidly involves one side of the body at seizure onset." ; oboInOwl:hasDbXref "UMLS:C1846620" ; oboInOwl:hasExactSynonym "Hemiclonic seizure", "Hemiclonic seizures", "Unilateral clonic seizure", "Unilateral clonic seizures" ; oboInOwl:id "HP:0006813" ; a owl:Class ; rdfs:comment "A seizure type typically occurring in certain epilepsy syndromes, such as Dravet syndrome and self-limited neonatal seizures." ; rdfs:label "Focal hemiclonic seizure" ; rdfs:subClassOf obo:HP_0002266 . obo:HP_0006817 obo:IAO_0000115 "Absence or underdevelopment of the vermis of cerebellum." ; oboInOwl:hasAlternativeId "HP:0005690", "HP:0007080" ; oboInOwl:hasDbXref "UMLS:C1855676", "UMLS:C3280770" ; oboInOwl:hasExactSynonym "Cerebellar vermis aplasia/hypoplasia", "Hypo/aplastic vermis" ; oboInOwl:hasRelatedSynonym "Cerebellar vermis aplasia or hypoplasia" ; oboInOwl:id "HP:0006817" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334, obo:HP_0007360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006818 obo:IAO_0000115 "A form of lissencephaly in which the cortex is thickened and has four more or less disorganized layers rather than six normal layers resulting from incomplete neuronal migration during brain development. At neuropathological examination, a 4-layered cortex consists of an upper molecular layer, a second thin cellular layer containing pyramidal neurons usually observed in layer V, a third pale poorly cellular layer and a fourth thick deep layer made up of neurons which had failed to migrate. Radiologocally would manifest as agyria or pachygyria with cortical thickness greater than 10 mm." ; oboInOwl:hasDbXref "MSH:D054221", "SNOMEDCT_US:253147000", "UMLS:C0431375" ; oboInOwl:hasExactSynonym "Classic lissencephaly", "Four-layered lissencephaly", "Lissencephaly, type I", "Type 1 lissencephaly", "Type I lissencephaly" ; oboInOwl:id "HP:0006818" ; a owl:Class ; rdfs:label "4-layered lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0006821 obo:IAO_0000115 "A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum." ; oboInOwl:hasDbXref "UMLS:C1847356" ; oboInOwl:hasExactSynonym "Polymicrogyria, anterior to posterior gradient" ; oboInOwl:id "HP:0006821" ; a owl:Class ; rdfs:label "Frontal polymicrogyria" ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0006824 oboInOwl:hasAlternativeId "HP:0001353", "HP:0002377" ; oboInOwl:hasDbXref "MSH:D003389", "SNOMEDCT_US:73013002", "UMLS:C0151311", "UMLS:C4025709" ; oboInOwl:hasExactSynonym "Cranial nerve palsies", "Cranial nerve palsy", "Cranial nerve paresis" ; oboInOwl:id "HP:0006824" ; a owl:Class ; rdfs:label "Cranial nerve paralysis" ; rdfs:subClassOf obo:HP_0031910 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006825 obo:IAO_0000115 "An abnormally pale appearance of the dorsal portion of the gray substance of the spinal cord. This finding can be observed by histological examination." ; oboInOwl:hasDbXref "UMLS:C1865416" ; oboInOwl:id "HP:0006825" ; a owl:Class ; rdfs:label "Pallor of dorsal columns of the spinal cord" ; rdfs:subClassOf obo:HP_0011397 . obo:HP_0006827 oboInOwl:hasDbXref "UMLS:C1389102" ; oboInOwl:hasExactSynonym "Degeneration of the spinal cord" ; oboInOwl:id "HP:0006827" ; a owl:Class ; rdfs:label "Atrophy of the spinal cord" ; rdfs:subClassOf obo:HP_0007344 . obo:HP_0006829 obo:IAO_0000115 "A severe degree of muscular hypotonia characterized by markedly reduced muscle tone." ; oboInOwl:hasAlternativeId "HP:0002347" ; oboInOwl:hasDbXref "UMLS:C1839630" ; oboInOwl:hasExactSynonym "Hypotonia, severe", "Severely decreased muscle tone" ; oboInOwl:id "HP:0006829" ; a owl:Class ; rdfs:label "Severe muscular hypotonia" ; rdfs:subClassOf obo:HP_0001252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001619 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006830 oboInOwl:consider "HP:0001319" ; oboInOwl:id "HP:0006830" ; a owl:Class ; rdfs:label "obsolete Severe neonatal hypotonia in males" ; owl:deprecated true . obo:HP_0006834 obo:IAO_0000115 "A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills, following the onset of epilepsy." ; oboInOwl:hasDbXref "UMLS:C1836829" ; oboInOwl:id "HP:0006834" ; a owl:Class ; rdfs:label "Developmental stagnation at onset of seizures" ; rdfs:subClassOf obo:HP_0007281 . obo:HP_0006837 obo:IAO_0000115 "A type of Horner syndrome with congenital onset." ; oboInOwl:hasDbXref "MSH:C564178", "UMLS:C1840475" ; oboInOwl:id "HP:0006837" ; a owl:Class ; rdfs:label "Congenital Horner syndrome" ; rdfs:subClassOf obo:HP_0002277 . obo:HP_0006844 obo:IAO_0000115 "Absence of the knee jerk reflex, which can normally be elicited by tapping the patellar tendon with a reflex hammer just below the patella." ; oboInOwl:hasDbXref "SNOMEDCT_US:274817009", "UMLS:C0558844" ; oboInOwl:hasExactSynonym "Absent knee jerk reflex" ; oboInOwl:id "HP:0006844" ; a owl:Class ; rdfs:label "Absent patellar reflexes" ; rdfs:subClassOf obo:HP_0002522 . obo:HP_0006846 oboInOwl:hasDbXref "SNOMEDCT_US:2776000", "UMLS:C1306587" ; oboInOwl:id "HP:0006846" ; a owl:Class ; rdfs:label "Acute encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0006849 obo:IAO_0000115 "Developmental defect characterized by a small and malformed corpus callosum." ; oboInOwl:hasDbXref "UMLS:C1850348" ; oboInOwl:id "HP:0006849" ; a owl:Class ; rdfs:label "Hypodysplasia of the corpus callosum" ; rdfs:subClassOf obo:HP_0002079 . obo:HP_0006850 obo:IAO_0000115 "Underdevelopment of the ventral portion of the pons." ; oboInOwl:hasDbXref "UMLS:C1843507" ; oboInOwl:hasExactSynonym "Underdeveloped ventral pons" ; oboInOwl:id "HP:0006850" ; a owl:Class ; rdfs:label "Hypoplasia of the ventral pons" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0012110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006851 obo:IAO_0000115 "Multiple neurofibromas of the spinal nerve roots with a symmetric distribution." ; oboInOwl:hasDbXref "UMLS:C1834236" ; oboInOwl:hasExactSynonym "Spinal nerve root neurofibromas, symmetric, multiple" ; oboInOwl:id "HP:0006851" ; a owl:Class ; rdfs:label "Symmetric spinal nerve root neurofibromas" ; rdfs:subClassOf obo:HP_0009735 . obo:HP_0006852 obo:IAO_0000115 "The occurrence of repeated episodes of generalized muscular hypotonia." ; oboInOwl:hasDbXref "UMLS:C4024976" ; oboInOwl:hasExactSynonym "Episodic generalised hypotonia" ; oboInOwl:id "HP:0006852" ; a owl:Class ; rdfs:label "Episodic generalized hypotonia" ; rdfs:subClassOf obo:HP_0001290 . obo:HP_0006855 obo:IAO_0000115 "Wasting (atrophy) of the vermis of cerebellum." ; oboInOwl:hasAlternativeId "HP:0007121", "HP:0007312" ; oboInOwl:hasDbXref "UMLS:C0742028" ; oboInOwl:hasExactSynonym "Atrophy of cerebellar vermis", "Atrophy of the cerebellar vermis", "Vermian atrophy" ; oboInOwl:id "HP:0006855" ; a owl:Class ; rdfs:comment "This sign can be visualized with brain MRI." ; rdfs:label "Cerebellar vermis atrophy" ; rdfs:subClassOf obo:HP_0001272, obo:HP_0002334 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006858 obo:IAO_0000115 "A loss or impairment of the sensation of the relative position of parts of the body and joint position occuring at distal joints." ; oboInOwl:hasAlternativeId "HP:0007056", "HP:0007148" ; oboInOwl:hasDbXref "UMLS:C4021585" ; oboInOwl:hasExactSynonym "Distal sensory loss of proprioception" ; oboInOwl:id "HP:0006858" ; a owl:Class ; rdfs:label "Impaired distal proprioception" ; rdfs:subClassOf obo:HP_0002936, obo:HP_0010831 . obo:HP_0006859 oboInOwl:hasDbXref "UMLS:C4024975" ; oboInOwl:id "HP:0006859" ; a owl:Class ; rdfs:label "Posterior leukoencephalopathy" ; rdfs:subClassOf obo:HP_0002352 . obo:HP_0006863 obo:IAO_0000115 "A severe delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." ; oboInOwl:hasDbXref "SNOMEDCT_US:62221000119105", "UMLS:C1851085" ; oboInOwl:id "HP:0006863" ; a owl:Class ; rdfs:label "Severe expressive language delay" ; rdfs:subClassOf obo:HP_0002474 . obo:HP_0006865 oboInOwl:hasDbXref "UMLS:C4024974" ; oboInOwl:id "HP:0006865" ; a owl:Class ; rdfs:label "Sensorimotor polyneuropathy affecting arms more than legs" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0006866 oboInOwl:hasDbXref "UMLS:C4024973" ; oboInOwl:hasExactSynonym "Midline CNS lipomas" ; oboInOwl:id "HP:0006866" ; a owl:Class ; rdfs:label "Midline central nervous system lipomas" ; rdfs:subClassOf obo:HP_0100251 . obo:HP_0006870 obo:IAO_0000115 "A type of holoprosencephaly in which most of the right and left cerebral hemispheres and lateral ventricles are separated but the most rostral aspect of the telencephalon, the frontal lobes, are fused, especially ventrally." ; oboInOwl:hasDbXref "MSH:D016142", "SNOMEDCT_US:253136007", "UMLS:C0431362" ; oboInOwl:id "HP:0006870" ; a owl:Class ; rdfs:label "Lobar holoprosencephaly" ; rdfs:subClassOf obo:HP_0001360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001360 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006872 obo:IAO_0000115 "Underdevelopment of the cerebrum." ; oboInOwl:hasAlternativeId "HP:0001322" ; oboInOwl:hasDbXref "UMLS:C1855330" ; oboInOwl:hasExactSynonym "Small cerebrum", "Underdeveloped cerebrum" ; oboInOwl:id "HP:0006872" ; a owl:Class ; rdfs:label "Cerebral hypoplasia" ; rdfs:subClassOf obo:HP_0007364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006873 obo:IAO_0000115 "A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4024972" ; oboInOwl:id "HP:0006873" ; a owl:Class ; rdfs:label "Symmetrical progressive peripheral demyelination" ; rdfs:subClassOf obo:HP_0007262 . obo:HP_0006877 obo:IAO_0100001 "HP:0001249" ; oboInOwl:id "HP:0006877" ; a owl:Class ; rdfs:label "obsolete Mental retardation, in some" ; owl:deprecated true . obo:HP_0006879 obo:IAO_0000115 "Atrophy affecting the pons and the cerebellum." ; oboInOwl:hasDbXref "UMLS:C1853766" ; oboInOwl:hasExactSynonym "Cerebellopontine atrophy" ; oboInOwl:id "HP:0006879" ; a owl:Class ; rdfs:label "Pontocerebellar atrophy" ; rdfs:subClassOf obo:HP_0001272, obo:HP_0007361 . obo:HP_0006880 obo:IAO_0000115 "A hemangioblastoma of the cerebellum." ; oboInOwl:hasAlternativeId "HP:0006761" ; oboInOwl:hasDbXref "NCIT:C3801", "UMLS:C1332900" ; oboInOwl:hasExactSynonym "Hemangioblastoma, sporadic cerebellar" ; oboInOwl:id "HP:0006880" ; a owl:Class ; rdfs:label "Cerebellar hemangioblastoma" ; rdfs:subClassOf obo:HP_0001317, obo:HP_0010797 . obo:HP_0006881 obo:IAO_0000115 "A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4024971" ; oboInOwl:id "HP:0006881" ; a owl:Class ; rdfs:label "Diffuse peripheral demyelination" ; rdfs:subClassOf obo:HP_0011096 . obo:HP_0006882 oboInOwl:hasDbXref "UMLS:C3278123" ; oboInOwl:id "HP:0006882" ; a owl:Class ; rdfs:label "Severe hydrocephalus" ; rdfs:subClassOf obo:HP_0000238 . obo:HP_0006886 obo:IAO_0000115 "A decrease in the ability to perceive vibration in the distal portions of the limbs." ; oboInOwl:hasDbXref "UMLS:C1853767" ; oboInOwl:hasExactSynonym "Decreased distal vibration sense" ; oboInOwl:id "HP:0006886" ; a owl:Class ; rdfs:label "Impaired distal vibration sensation" ; rdfs:subClassOf obo:HP_0002495 . obo:HP_0006887 obo:IAO_0000115 "The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time." ; oboInOwl:hasAlternativeId "HP:0001261", "HP:0006924", "HP:0007025", "HP:0007044", "HP:0007243" ; oboInOwl:hasDbXref "UMLS:C1846149" ; oboInOwl:hasExactSynonym "Intellectual disability, progressive", "Mental retardation, progressive", "Progressive mental retardation" ; oboInOwl:id "HP:0006887" ; a owl:Class ; rdfs:label "Intellectual disability, progressive" ; rdfs:subClassOf obo:HP_0001249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001249 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0006888 oboInOwl:hasDbXref "SNOMEDCT_US:52330001", "UMLS:C0266456" ; oboInOwl:id "HP:0006888" ; a owl:Class ; rdfs:label "Meningoencephalocele" ; rdfs:subClassOf obo:HP_0002084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002360 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006889 obo:IAO_0000115 "Borderline intellectual disability is defined as an intelligence quotient (IQ) in the range of 70-85." ; oboInOwl:hasDbXref "SNOMEDCT_US:77287004", "UMLS:C0006009" ; oboInOwl:hasExactSynonym "Intellectual disability, borderline", "Mental retardation, borderline" ; oboInOwl:id "HP:0006889" ; a owl:Class ; rdfs:comment "We choose to define the concept of borderline intellectual disability onthe basis of the commonly used range of 70-85 (IQ), but note that in DSM-5, IQ boundaries are no longer part of the classification." ; rdfs:label "Intellectual disability, borderline" ; rdfs:subClassOf obo:HP_0001249 . obo:HP_0006891 oboInOwl:hasDbXref "UMLS:C4024970" ; oboInOwl:id "HP:0006891" ; a owl:Class ; rdfs:label "Thick cerebral cortex" ; rdfs:subClassOf obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006892 obo:IAO_0000115 "Atrophy (wasting, decrease in size of cells or tissue) affecting the frontotemporal cerebrum." ; oboInOwl:hasDbXref "UMLS:C4021584" ; oboInOwl:hasExactSynonym "Cerebral atrophy, frontotemporal" ; oboInOwl:id "HP:0006892" ; a owl:Class ; rdfs:label "Frontotemporal cerebral atrophy" ; rdfs:subClassOf obo:HP_0002059 . obo:HP_0006893 obo:IAO_0100001 "HP:0007033" ; oboInOwl:id "HP:0006893" ; a owl:Class ; rdfs:comment "Use Cerebellar dysplasia (HP:0007033) with the modifier Severe." ; rdfs:label "obsolete Severely dysplastic cerebellum" ; owl:deprecated true . obo:HP_0006894 oboInOwl:hasDbXref "UMLS:C1859231" ; oboInOwl:id "HP:0006894" ; a owl:Class ; rdfs:label "Hypoplastic olfactory lobes" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0025057 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005366 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006895 oboInOwl:hasDbXref "UMLS:C1845245" ; oboInOwl:id "HP:0006895" ; a owl:Class ; rdfs:label "Lower limb hypertonia" ; rdfs:subClassOf obo:HP_0002509 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001618 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001383 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006896 obo:IAO_0000115 "Fleeting perceptual experiences that occur during the transition from sleep to wakefulness." ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:69690008", "UMLS:C0424082" ; oboInOwl:id "HP:0006896" ; a owl:Class ; rdfs:label "Hypnopompic hallucinations" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0006897 obo:IAO_0000115 "Malfunction of the abducens nerve as manifested by impairment of the ability of the affected eye to be moved outward. Patients who develop abducens nerve palsy often present with binocular horizontal diplopia, which is a double vision when looking at objects side by side. There will be a notable weakness of the ipsilateral lateral rectus muscle leading to a deficit in of eye abduction on the affected side. Some patients may present with a constant head turning movement to maintain binocular fusion and to lessen the degree of diplopia." ; oboInOwl:hasAlternativeId "HP:0011349" ; oboInOwl:hasDbXref "MSH:C564661", "MSH:D020434", "SNOMEDCT_US:398760006", "SNOMEDCT_US:398925009", "SNOMEDCT_US:398963001", "UMLS:C0271355" ; oboInOwl:hasExactSynonym "Abducens nerve palsy", "Abducens nerve paralysis", "Abducens nerve paresis", "Cranial nerve VI palsy", "Lateral rectus muscle denervation paresis", "Sixth nerve palsy" ; oboInOwl:id "HP:0006897" ; a owl:Class ; rdfs:comment "Affected individuals may experience diplopia as well as esotropia or convergent strabismus." ; rdfs:label "Abducens palsy" ; rdfs:subClassOf obo:HP_0006824 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006899 oboInOwl:hasDbXref "UMLS:C1866131" ; oboInOwl:id "HP:0006899" ; a owl:Class ; rdfs:label "Fusion of the cerebellar hemispheres" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0014890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006901 obo:IAO_0100001 "HP:0010829" ; oboInOwl:id "HP:0006901" ; a owl:Class ; rdfs:label "obsolete Impaired thermal sensitivity" ; owl:deprecated true . obo:HP_0006903 oboInOwl:hasDbXref "UMLS:C4024967" ; oboInOwl:id "HP:0006903" ; a owl:Class ; rdfs:label "Congenital peripheral neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0006904 oboInOwl:hasDbXref "UMLS:C1856604" ; oboInOwl:id "HP:0006904" ; a owl:Class ; rdfs:label "Late-onset spinocerebellar degeneration" ; rdfs:subClassOf obo:HP_0002503 . obo:HP_0006906 obo:IAO_0000115 "The presence of calcium deposition within brain structures that is present already at the time of birth." ; oboInOwl:hasDbXref "UMLS:C4024966" ; oboInOwl:id "HP:0006906" ; a owl:Class ; rdfs:label "Congenital intracerebral calcification" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0006913 obo:IAO_0000115 "Atrophy of the frontal cortex." ; oboInOwl:hasDbXref "UMLS:C4024965" ; oboInOwl:hasExactSynonym "Frontal cortex degeneration" ; oboInOwl:id "HP:0006913" ; a owl:Class ; rdfs:label "Frontal cortical atrophy" ; rdfs:subClassOf obo:HP_0002120 . obo:HP_0006915 oboInOwl:hasDbXref "UMLS:C1859200" ; oboInOwl:hasExactSynonym "Inability to walk by childhood/adolescence" ; oboInOwl:id "HP:0006915" ; a owl:Class ; rdfs:label "Inability to walk by childhood/adolescence" ; rdfs:subClassOf obo:HP_0002540 . obo:HP_0006916 obo:IAO_0000115 "Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons." ; oboInOwl:hasDbXref "UMLS:C1832339", "UMLS:C4024964" ; oboInOwl:hasRelatedSynonym "Intraaxonal accumulation of curvilinear profiles" ; oboInOwl:id "HP:0006916" ; a owl:Class ; rdfs:label "Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material" ; rdfs:subClassOf obo:HP_0003205 . obo:HP_0006918 oboInOwl:hasDbXref "MSH:D002549", "SNOMEDCT_US:49692006", "UMLS:C0007795" ; oboInOwl:id "HP:0006918" ; a owl:Class ; rdfs:label "Diffuse cerebral sclerosis" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0006919 oboInOwl:hasBroadSynonym "Aggressive/violent behavior", "Aggressive/violent behaviour" ; oboInOwl:hasDbXref "UMLS:C4024963" ; oboInOwl:hasExactSynonym "Abnormal aggressive, impulsive or violent behaviour" ; oboInOwl:id "HP:0006919" ; a owl:Class ; rdfs:label "Abnormal aggressive, impulsive or violent behavior" ; rdfs:subClassOf obo:HP_0100851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0000718 obo:HP_0008760 obo:HP_0100710 ) ] ] . obo:HP_0006921 obo:IAO_0000115 "Stiffness (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) of the axial musculature." ; oboInOwl:hasDbXref "UMLS:C4024962" ; oboInOwl:id "HP:0006921" ; a owl:Class ; rdfs:label "Axial muscle stiffness" ; rdfs:subClassOf obo:HP_0003552, obo:HP_0040286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003897 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000632 ] ) ] ] . obo:HP_0006926 obo:IAO_0100001 "HP:0002415" ; oboInOwl:id "HP:0006926" ; a owl:Class ; rdfs:label "obsolete Metachromatic leukodystrophy variant" ; owl:deprecated true . obo:HP_0006927 obo:IAO_0000115 "Excessive number of small gyri (convolutions) on the surface of one side of the brain." ; oboInOwl:hasDbXref "SNOMEDCT_US:715905006", "UMLS:C4024960" ; oboInOwl:id "HP:0006927" ; a owl:Class ; rdfs:label "Unilateral polymicrogyria" ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0006929 obo:IAO_0000115 "Brain damage related to a lowering of blood glucose below a critical level (around 30 mg/dl), which may lead to confusion, lethargy and delirium followed by seizures and coma. Prolonged hypoglycemia may lead to irreversible brain damage." ; oboInOwl:hasDbXref "SNOMEDCT_US:64624009", "UMLS:C0149877" ; oboInOwl:id "HP:0006929" ; a owl:Class ; rdfs:label "Hypoglycemic encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0006930 obo:IAO_0000115 "The presence of developmental dysplasia of the cortex of frontal lobe and the cortex of parietal lobe." ; oboInOwl:hasDbXref "UMLS:C4024959" ; oboInOwl:id "HP:0006930" ; a owl:Class ; rdfs:label "Frontoparietal cortical dysplasia" ; rdfs:subClassOf obo:HP_0002539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001870 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016530 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006931 obo:IAO_0000115 "Pericallosal lipomas are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum of the brain." ; oboInOwl:hasDbXref "UMLS:C1333160" ; oboInOwl:hasExactSynonym "Lipoma of corpus callosum" ; oboInOwl:id "HP:0006931" ; a owl:Class ; rdfs:label "Pericallosal lipoma" ; rdfs:subClassOf obo:HP_0001273, obo:HP_0006866 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001012 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006932 oboInOwl:hasDbXref "UMLS:C4024958" ; oboInOwl:id "HP:0006932" ; a owl:Class ; rdfs:label "Transient psychotic episodes" ; rdfs:subClassOf obo:HP_0000725 . obo:HP_0006934 obo:IAO_0000115 "Nystagmus dating from or present at birth." ; oboInOwl:hasDbXref "MSH:D020417", "SNOMEDCT_US:64635004", "UMLS:C0700501" ; oboInOwl:hasRelatedSynonym "Nystagmus, congenital" ; oboInOwl:id "HP:0006934" ; a owl:Class ; rdfs:label "Congenital nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0006937 obo:IAO_0000115 "A reduced sense of touch (tactile sensation) on the skin of the distal limbs. This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus." ; oboInOwl:hasAlternativeId "HP:0006981" ; oboInOwl:hasDbXref "UMLS:C4021583" ; oboInOwl:hasExactSynonym "Decreased distal touch sense", "Decreased touch sensation in extremities" ; oboInOwl:id "HP:0006937" ; a owl:Class ; rdfs:label "Impaired distal tactile sensation" ; rdfs:subClassOf obo:HP_0002936, obo:HP_0010830 . obo:HP_0006938 obo:IAO_0000115 "A decrease in the ability to perceive vibration at the ankles. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to the malleoli of the ankles." ; oboInOwl:hasAlternativeId "HP:0007144" ; oboInOwl:hasDbXref "UMLS:C1854372" ; oboInOwl:hasExactSynonym "Decreased vibration sense at ankles", "Decreased vibration sense in feet", "Impaired vibration sensation at ankles" ; oboInOwl:id "HP:0006938" ; a owl:Class ; rdfs:label "Impaired vibration sensation at ankles" ; rdfs:subClassOf obo:HP_0002166, obo:HP_0006886 . obo:HP_0006943 oboInOwl:hasDbXref "UMLS:C1858857" ; oboInOwl:id "HP:0006943" ; a owl:Class ; rdfs:label "Diffuse spongiform leukoencephalopathy" ; rdfs:subClassOf obo:HP_0002352 . obo:HP_0006944 obo:IAO_0000115 "A complete loss of the ability to perceive vibration." ; oboInOwl:hasDbXref "UMLS:C1837520" ; oboInOwl:hasExactSynonym "Apallesthesia" ; oboInOwl:id "HP:0006944" ; a owl:Class ; rdfs:label "Abolished vibration sense" ; rdfs:subClassOf obo:HP_0002495 . obo:HP_0006946 obo:IAO_0000115 "An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis." ; oboInOwl:hasDbXref "UMLS:C0746495" ; oboInOwl:id "HP:0006946" ; a owl:Class ; rdfs:label "Recurrent meningitis" ; rdfs:subClassOf obo:HP_0011450 . obo:HP_0006949 oboInOwl:hasDbXref "UMLS:C1848695" ; oboInOwl:id "HP:0006949" ; a owl:Class ; rdfs:label "Episodic peripheral neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0006951 oboInOwl:hasDbXref "UMLS:C1845370" ; oboInOwl:id "HP:0006951" ; a owl:Class ; rdfs:label "Retrocerebellar cyst" ; rdfs:subClassOf obo:HP_0002350 . obo:HP_0006955 obo:IAO_0000115 "Hypoplasia of the cerebellum, pontine nuclei, and inferior olivary nucleus." ; oboInOwl:hasAlternativeId "HP:0007168" ; oboInOwl:hasDbXref "UMLS:C1859341" ; oboInOwl:id "HP:0006955" ; a owl:Class ; rdfs:label "Olivopontocerebellar hypoplasia" ; rdfs:subClassOf obo:HP_0001321, obo:HP_0012110 . obo:HP_0006956 oboInOwl:hasAlternativeId "HP:0006796", "HP:0006945", "HP:0007173" ; oboInOwl:hasDbXref "UMLS:C1856409" ; oboInOwl:hasExactSynonym "Dilatation of lateral cerebral ventricles", "Dilation of lateral ventricles", "Enlarged lateral ventricles", "Lateral ventricle dilatation" ; oboInOwl:id "HP:0006956" ; a owl:Class ; rdfs:label "Lateral ventricle dilatation" ; rdfs:subClassOf obo:HP_0002119, obo:HP_0030047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002285 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006957 obo:IAO_0100001 "HP:0002505" ; oboInOwl:id "HP:0006957" ; a owl:Class ; rdfs:label "obsolete Loss of ability to walk" ; owl:deprecated true . obo:HP_0006958 obo:IAO_0000115 "An abnormality of the auditory evoked potentials, which are used to trace the signal generated by a sound, from the cochlear nerve, through the lateral lemniscus, to the medial geniculate nucleus, and to the cortex." ; oboInOwl:hasAlternativeId "HP:0003151", "HP:0004462", "HP:0006923" ; oboInOwl:hasDbXref "SNOMEDCT_US:102971006", "UMLS:C0522216" ; oboInOwl:hasExactSynonym "Abnormal brainstem auditory-evoked potentials" ; oboInOwl:id "HP:0006958" ; a owl:Class ; rdfs:comment "Auditory brainstem response audiometry typically uses a click stimulus that generates a response from the basilar region of the cochlea." ; rdfs:label "Abnormal auditory evoked potentials" ; rdfs:subClassOf obo:HP_0030177, obo:HP_0030178 . obo:HP_0006959 obo:IAO_0000115 "Proximal spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." ; oboInOwl:hasDbXref "UMLS:C4024957" ; oboInOwl:id "HP:0006959" ; a owl:Class ; rdfs:label "Proximal spinal muscular atrophy" ; rdfs:subClassOf obo:HP_0007269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001999 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006960 obo:IAO_0000115 "The presence of calcium deposition in the choroid plexus." ; oboInOwl:hasDbXref "UMLS:C1863184" ; oboInOwl:hasExactSynonym "Calcified choroid plexus" ; oboInOwl:id "HP:0006960" ; a owl:Class ; rdfs:label "Choroid plexus calcification" ; rdfs:subClassOf obo:HP_0002514, obo:HP_0007376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001886 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006961 oboInOwl:hasDbXref "UMLS:C1855568" ; oboInOwl:hasExactSynonym "Head jerking", "Jerking head movements" ; oboInOwl:id "HP:0006961" ; a owl:Class ; rdfs:label "Jerky head movements" ; rdfs:subClassOf obo:HP_0002457 . obo:HP_0006962 oboInOwl:hasDbXref "UMLS:C1837016" ; oboInOwl:hasExactSynonym "Unstable walking, worse in the dark" ; oboInOwl:id "HP:0006962" ; a owl:Class ; rdfs:label "Gait instability, worse in the dark" ; rdfs:subClassOf obo:HP_0002317 . obo:HP_0006964 oboInOwl:hasDbXref "UMLS:C1859863" ; oboInOwl:id "HP:0006964" ; a owl:Class ; rdfs:label "Cerebral cortical neurodegeneration" ; rdfs:subClassOf obo:HP_0007369 . obo:HP_0006965 oboInOwl:hasDbXref "UMLS:C1855020" ; oboInOwl:id "HP:0006965" ; a owl:Class ; rdfs:label "Acute necrotizing encephalopathy" ; rdfs:subClassOf obo:HP_0006846 . obo:HP_0006970 obo:IAO_0000115 "Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia." ; oboInOwl:hasDbXref "MSH:D007969", "SNOMEDCT_US:230769007", "UMLS:C0023529" ; oboInOwl:hasExactSynonym "PVL" ; oboInOwl:id "HP:0006970" ; a owl:Class ; rdfs:comment "Periventricular leukomalacia is the leading known cause of cerebral palsy. Magnetic resonance imaging-based neuroimaging techniques provide greater diagnostic sensitivity for PVL than does head ultrasonography and often document the involvement of telencephalic gray matter and long tracts in addition to periventricular white matter." ; rdfs:label "Periventricular leukomalacia" ; rdfs:subClassOf obo:HP_0002518 . obo:HP_0006976 obo:IAO_0000115 "A type of encephalopathy (brain disease, damage, or malfunction accompanied by an altered mental state) that is characterized by evidence of necrosis of brain tissue." ; oboInOwl:hasDbXref "UMLS:C1396481" ; oboInOwl:id "HP:0006976" ; a owl:Class ; rdfs:comment "The disease acute necrotizing encephalopathy is characterized by acute onset encephalopathy with rapid, progressive neurologic deterioration, seizures and symmetric multifocal brain lesions. This term is kept for convenience. For new annotations, it is recommended that the specific phenotypic abnormalities be noted." ; rdfs:label "Necrotizing encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0006977 obo:IAO_0000115 "Deficit in grammar, including syntax and morphology." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "UMLS:C4024956" ; oboInOwl:hasExactSynonym "Grammar-specific speech disorder" ; oboInOwl:id "HP:0006977" ; a owl:Class ; rdfs:label "Deficit in grammar" ; rdfs:subClassOf obo:HP_0002463 . obo:HP_0006978 oboInOwl:hasDbXref "UMLS:C3278204" ; oboInOwl:id "HP:0006978" ; a owl:Class ; rdfs:label "Dysmyelinating leukodystrophy" ; rdfs:subClassOf obo:HP_0002415 . obo:HP_0006979 obo:IAO_0000115 "Any abnormal alteration of an individual's circadian rhythm that affects the timing of sleeping and being awake." ; oboInOwl:hasDbXref "UMLS:C1833362" ; oboInOwl:hasExactSynonym "Sleep-wake cycle disturbance" ; oboInOwl:id "HP:0006979" ; a owl:Class ; rdfs:label "Sleep-wake cycle disturbance" ; rdfs:subClassOf obo:HP_0002360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0022410 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006980 obo:IAO_0000115 "Leukoencephalopathy that gets more severe with time." ; oboInOwl:hasDbXref "UMLS:C1855010" ; oboInOwl:hasExactSynonym "Leukoencephalopathy, progressive" ; oboInOwl:id "HP:0006980" ; a owl:Class ; rdfs:label "Progressive leukoencephalopathy" ; rdfs:subClassOf obo:HP_0002352 . obo:HP_0006983 obo:IAO_0100001 "HP:0002510" ; oboInOwl:id "HP:0006983" ; a owl:Class ; rdfs:label "obsolete Slowly progressive spastic quadriparesis" ; owl:deprecated true . obo:HP_0006984 obo:IAO_0100001 "HP:0003409" ; oboInOwl:id "HP:0006984" ; a owl:Class ; rdfs:label "obsolete Distal sensory loss of all modalities" ; owl:deprecated true . obo:HP_0006986 oboInOwl:hasDbXref "SNOMEDCT_US:394680009", "UMLS:C1273957" ; oboInOwl:hasExactSynonym "Uncontrollable movement in upper arms" ; oboInOwl:id "HP:0006986" ; a owl:Class ; rdfs:label "Upper limb spasticity" ; rdfs:subClassOf obo:HP_0034353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001257 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006988 obo:IAO_0000115 "A type of holoprosencephaly characterized by the presence of a single ventricle and no separation of the cerebral hemisphere. The single midline ventricle is often greatly enlarged." ; oboInOwl:hasDbXref "MSH:D016142", "SNOMEDCT_US:253137003", "UMLS:C0431363" ; oboInOwl:id "HP:0006988" ; a owl:Class ; rdfs:label "Alobar holoprosencephaly" ; rdfs:subClassOf obo:HP_0001360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001360 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006989 obo:IAO_0000115 "Dysplasia and dysgenesis of the corpus callosum are nonspecific descriptions that imply defective development of the corpus callosum. The term dysplasia is applied when the morphology of the corpus callosum is altered as a congenital trait. For instance, the corpus callosum may be hump-shaped, kinked, or a striped corpus callosum that lacks an anatomically distinct genu and splenium." ; oboInOwl:hasAlternativeId "HP:0006996" ; oboInOwl:hasDbXref "UMLS:C0431369" ; oboInOwl:hasExactSynonym "Dysgenesis of corpus callosum", "Dysplasia of corpus callosum" ; oboInOwl:id "HP:0006989" ; a owl:Class ; rdfs:label "Dysplastic corpus callosum" ; rdfs:subClassOf obo:HP_0001273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0006990 obo:IAO_0000115 "A type of gliosis that occurs in the vicinity of injured neurons." ; oboInOwl:hasDbXref "UMLS:C4024954" ; oboInOwl:id "HP:0006990" ; a owl:Class ; rdfs:label "Myelin-dependent gliosis" ; rdfs:subClassOf obo:HP_0002171 . obo:HP_0006992 oboInOwl:hasDbXref "UMLS:C1850961" ; oboInOwl:id "HP:0006992" ; a owl:Class ; rdfs:label "Anterior basal encephalocele" ; rdfs:subClassOf obo:HP_0002084 . obo:HP_0006994 oboInOwl:hasDbXref "UMLS:C1868514" ; oboInOwl:id "HP:0006994" ; a owl:Class ; rdfs:label "Diffuse leukoencephalopathy" ; rdfs:subClassOf obo:HP_0002352 . obo:HP_0006999 obo:IAO_0000115 "Focal proliferation of glial cells in the basal ganglia." ; oboInOwl:hasDbXref "UMLS:C1864114", "UMLS:C2750915" ; oboInOwl:hasExactSynonym "Gliosis in the basal ganglia" ; oboInOwl:id "HP:0006999" ; a owl:Class ; rdfs:comment "Gliosis refers to a proliferation of astrocytes in an area of damage of nervous tissue." ; rdfs:label "Basal ganglia gliosis" ; rdfs:subClassOf obo:HP_0002134, obo:HP_0002171 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002420 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007000 oboInOwl:hasDbXref "UMLS:C1847164" ; oboInOwl:id "HP:0007000" ; a owl:Class ; rdfs:label "Morning myoclonic jerks" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0007001 oboInOwl:hasDbXref "UMLS:C1849146" ; oboInOwl:id "HP:0007001" ; a owl:Class ; rdfs:label "Loss of Purkinje cells in the cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001999 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000121 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007002 obo:IAO_0000115 "Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg." ; oboInOwl:hasAlternativeId "HP:0007349" ; oboInOwl:hasDbXref "UMLS:C1854570", "UMLS:C2749625", "UMLS:C4020811" ; oboInOwl:hasRelatedSynonym "Distal motor neuropathy", "Length dependent motor neuropathy" ; oboInOwl:id "HP:0007002" ; a owl:Class ; rdfs:comment "Distal motor neuropathy is a bundled term that should not be used if more detailed information about the phenotype is available." ; rdfs:label "Motor axonal neuropathy" ; rdfs:subClassOf obo:HP_0003477 . obo:HP_0007006 oboInOwl:hasDbXref "UMLS:C4024953" ; oboInOwl:id "HP:0007006" ; a owl:Class ; rdfs:label "Dorsal column degeneration" ; rdfs:subClassOf obo:HP_0011397 . obo:HP_0007007 obo:IAO_0000115 "The formation of small cavities in the tissue of the basal ganglia." ; oboInOwl:hasAlternativeId "HP:0007246" ; oboInOwl:hasDbXref "UMLS:C4024952" ; oboInOwl:id "HP:0007007" ; a owl:Class ; rdfs:comment "This feature can be observed in tissue upon autopsy or in magnetic resonance tomography (MRI) images." ; rdfs:label "Cavitation of the basal ganglia" ; rdfs:subClassOf obo:HP_0002134 . obo:HP_0007009 oboInOwl:hasDbXref "UMLS:C3277687" ; oboInOwl:hasExactSynonym "CNS degeneration" ; oboInOwl:id "HP:0007009" ; a owl:Class ; rdfs:label "Central nervous system degeneration" ; rdfs:subClassOf obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007010 obo:IAO_0000115 "An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes." ; oboInOwl:hasDbXref "UMLS:C1867864" ; oboInOwl:hasExactSynonym "Fine motor disability", "Fine motor impairment", "Fine motor skill dysfunction", "Impaired fine motor skills" ; oboInOwl:id "HP:0007010" ; a owl:Class ; rdfs:label "Poor fine motor coordination" ; rdfs:subClassOf obo:HP_0002275 . obo:HP_0007011 obo:IAO_0000115 "Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly." ; oboInOwl:hasDbXref "MSH:D020432", "SNOMEDCT_US:20610004", "UMLS:C0271375" ; oboInOwl:hasExactSynonym "Trochlear nerve palsy" ; oboInOwl:id "HP:0007011" ; a owl:Class ; rdfs:comment "The fourth cranial nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit." ; rdfs:label "Fourth cranial nerve palsy" ; rdfs:subClassOf obo:HP_0006824 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001644 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007015 obo:IAO_0000115 "An abnormality of the ability (skills) to perform a precise movement of large muscles with the intent to perform a specific act. Gross motor skills are required to mediate movements of the arms, legs, and other large body parts." ; oboInOwl:hasDbXref "UMLS:C1867863" ; oboInOwl:hasExactSynonym "Gross motor impairment" ; oboInOwl:id "HP:0007015" ; a owl:Class ; rdfs:label "Poor gross motor coordination" ; rdfs:subClassOf obo:HP_0002275 . obo:HP_0007016 oboInOwl:hasDbXref "UMLS:C1844007" ; oboInOwl:id "HP:0007016" ; a owl:Class ; rdfs:label "Corticospinal tract hypoplasia" ; rdfs:subClassOf obo:HP_0007365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007017 oboInOwl:hasBroadSynonym "Forgetfullness" ; oboInOwl:hasDbXref "UMLS:C3277688" ; oboInOwl:id "HP:0007017" ; a owl:Class ; rdfs:label "Progressive forgetfulness" ; rdfs:subClassOf obo:HP_0002354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001818 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007018 obo:IAO_0000115 "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." ; oboInOwl:hasAlternativeId "HP:0001576", "HP:0001577", "HP:0006973" ; oboInOwl:hasDbXref "MSH:D001289", "SNOMEDCT_US:406506008", "SNOMEDCT_US:7461003", "UMLS:C1263846" ; oboInOwl:hasExactSynonym "ADHD", "Attention deficit", "Attention deficit disorder", "Attention deficit-hyperactivity disorder", "Attention deficits", "Childhood attention deficit/hyperactivity disorder" ; oboInOwl:id "HP:0007018" ; a owl:Class ; rdfs:label "Attention deficit hyperactivity disorder" ; rdfs:subClassOf obo:HP_0000736, obo:HP_0000752 . obo:HP_0007020 oboInOwl:hasAlternativeId "HP:0006875", "HP:0007255" ; oboInOwl:hasDbXref "UMLS:C1855483" ; oboInOwl:id "HP:0007020" ; a owl:Class ; rdfs:label "Progressive spastic paraplegia" ; rdfs:subClassOf obo:HP_0001258 . obo:HP_0007021 obo:IAO_0000115 "Inability to perceive painful stimuli." ; oboInOwl:hasAlternativeId "HP:0003404" ; oboInOwl:hasDbXref "SNOMEDCT_US:38433004", "UMLS:C0344307" ; oboInOwl:hasExactSynonym "Absence of pain sensation" ; oboInOwl:id "HP:0007021" ; a owl:Class ; rdfs:comment "The word Anesthesia is occasionally used to refer to lack of pain sensation, although it is more usually used to denote a medical procedure design to relieve pain." ; rdfs:label "Pain insensitivity" ; rdfs:subClassOf obo:HP_0007328 . obo:HP_0007023 obo:IAO_0000115 "Cerebral hemorrhage that occurs before birth." ; oboInOwl:hasDbXref "UMLS:C1837247" ; oboInOwl:hasExactSynonym "Antenatal intracerebral haemorrhage" ; oboInOwl:id "HP:0007023" ; a owl:Class ; rdfs:label "Antenatal intracerebral hemorrhage" ; rdfs:subClassOf obo:HP_0001342 . obo:HP_0007024 obo:IAO_0000115 "Bilateral impairment of the function of the cranial nerves 9-12, which control musculature involved in eating, swallowing, and speech. Pseudobulbar paralysis is characterized clinically by dysarthria, dysphonia, and dysphagia with bifacial paralysis, and may be accompanied by Pseudobulbar behavioral symptoms such as enforced crying and laughing." ; oboInOwl:hasAlternativeId "HP:0002201", "HP:0006819" ; oboInOwl:hasDbXref "MSH:D020828", "SNOMEDCT_US:7379000", "UMLS:C0033790" ; oboInOwl:hasExactSynonym "Pseudobulbar palsy", "Pseudobulbar syndrome" ; oboInOwl:id "HP:0007024" ; a owl:Class ; rdfs:label "Pseudobulbar paralysis" ; rdfs:subClassOf obo:HP_0001260, obo:HP_0001618, obo:HP_0002015, obo:HP_0002200, obo:HP_0003470 . obo:HP_0007027 obo:IAO_0000115 "A morphological abnormality of the metencephalon." ; oboInOwl:hasDbXref "UMLS:C4024951" ; oboInOwl:id "HP:0007027" ; a owl:Class ; rdfs:comment "The metencephalon comprises the pons and the cerebellum; contains a portion of the fourth ventricle; and the trigeminal nerve, abducens nerve, facial nerve, and a portion of the vestibulocochlear nerve. The metencephalon is part of the hindbrain." ; rdfs:label "Poorly formed metencephalon" ; rdfs:subClassOf obo:HP_0011283 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001895 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007029 obo:IAO_0000115 "A small, sac-like aneurysm (outpouching) of a cerebral blood vessel." ; oboInOwl:hasDbXref "MSH:D000783", "SNOMEDCT_US:54002007", "UMLS:C2713497" ; oboInOwl:hasExactSynonym "Cerebral saccular aneurysm" ; oboInOwl:id "HP:0007029" ; a owl:Class ; rdfs:comment "Saccular aneurysms are often said to have a berry-shaped appearance, whence the name." ; rdfs:label "Cerebral berry aneurysm" ; rdfs:subClassOf obo:HP_0004944 . obo:HP_0007030 oboInOwl:hasDbXref "UMLS:C4024950" ; oboInOwl:id "HP:0007030" ; a owl:Class ; rdfs:label "Nonprogressive encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0007033 obo:IAO_0000115 "Cerebellar dysplasia (abnormal growth or development) is defined by abnormal cerebellar foliation, white matter arborization, and gray-white matter junction. Cerebellar dysplasia is a neuroimaging finding that describes abnormalities of both the cerebellar cortex and white matter and is associated with variable neurodevelopmental outcome. Dysplasia may globally involve the cerebellum or affect only one cerebellar hemisphere. In addition, cerebellar dysplasia may be associated with cortical/subcortical cysts." ; oboInOwl:hasAlternativeId "HP:0006893" ; oboInOwl:hasDbXref "UMLS:C3278322" ; oboInOwl:id "HP:0007033" ; a owl:Class ; rdfs:comment "Any part of the cerebellum can be dysplastic, from small focal regions within one hemisphere to abnormal foliation throughout the cerebellum. Hypoplastic cerebella are frequently also dysmorphic, as observed in tubulinopathies and cobblestone malformations." ; rdfs:label "Cerebellar dysplasia" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007034 oboInOwl:hasDbXref "UMLS:C4024949" ; oboInOwl:hasExactSynonym "Generalised hyperreflexia" ; oboInOwl:id "HP:0007034" ; a owl:Class ; rdfs:label "Generalized hyperreflexia" ; rdfs:subClassOf obo:HP_0001347 . obo:HP_0007035 oboInOwl:hasDbXref "UMLS:C4024948" ; oboInOwl:id "HP:0007035" ; a owl:Class ; rdfs:label "Anterior encephalocele" ; rdfs:subClassOf obo:HP_0002084 . obo:HP_0007036 oboInOwl:hasDbXref "UMLS:C1856655" ; oboInOwl:hasExactSynonym "Underdeveloped olfactory tract" ; oboInOwl:id "HP:0007036" ; a owl:Class ; rdfs:label "Hypoplasia of olfactory tract" ; rdfs:subClassOf obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002265 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007039 oboInOwl:hasDbXref "UMLS:C4024947" ; oboInOwl:id "HP:0007039" ; a owl:Class ; rdfs:label "Symmetric lesions of the basal ganglia" ; rdfs:subClassOf obo:HP_0002134 . obo:HP_0007041 obo:IAO_0000115 "Meningitis that persists for more than 4 weeks, and lymphocytes are present in the cerebrospinal fluid (CSF)." ; oboInOwl:hasDbXref "SNOMEDCT_US:230154004", "UMLS:C0393441" ; oboInOwl:id "HP:0007041" ; a owl:Class ; rdfs:label "Chronic lymphocytic meningitis" ; rdfs:subClassOf obo:HP_0001287 . obo:HP_0007042 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4024946" ; oboInOwl:id "HP:0007042" ; a owl:Class ; rdfs:label "Focal white matter lesions" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0007045 oboInOwl:hasDbXref "UMLS:C1855487" ; oboInOwl:id "HP:0007045" ; a owl:Class ; rdfs:label "Midline brain calcifications" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0007047 obo:IAO_0000115 "Partial or complete wasting (loss) of dentate nucleus." ; oboInOwl:hasDbXref "UMLS:C1857788" ; oboInOwl:id "HP:0007047" ; a owl:Class ; rdfs:label "Atrophy of the dentate nucleus" ; rdfs:subClassOf obo:HP_0100321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007048 obo:IAO_0000115 "Increased size of the basal ganglia." ; oboInOwl:hasDbXref "UMLS:C1859470" ; oboInOwl:id "HP:0007048" ; a owl:Class ; rdfs:label "Large basal ganglia" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007052 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1833434" ; oboInOwl:id "HP:0007052" ; a owl:Class ; rdfs:label "Multifocal cerebral white matter abnormalities" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0007054 obo:IAO_0000115 "Hyperactive stretch reflexes of muscles that move proximal joints (elbow, knee)." ; oboInOwl:hasDbXref "UMLS:C1836012" ; oboInOwl:hasExactSynonym "Hyperreflexia proximally" ; oboInOwl:id "HP:0007054" ; a owl:Class ; rdfs:label "Proximal hyperreflexia" ; rdfs:subClassOf obo:HP_0001347 . obo:HP_0007057 oboInOwl:hasDbXref "UMLS:C1845864" ; oboInOwl:id "HP:0007057" ; a owl:Class ; rdfs:label "Poor hand-eye coordination" ; rdfs:subClassOf obo:HP_0002370 . obo:HP_0007058 obo:IAO_0000115 "Generalized atrophy or hypoplasia of the cerebrum." ; oboInOwl:hasDbXref "UMLS:C4024945" ; oboInOwl:hasExactSynonym "Generalised cerebral atrophy/hypoplasia", "Generalised cerebral degeneration/underdevelopment", "Generalized cerebral degeneration/underdevelopment" ; oboInOwl:id "HP:0007058" ; a owl:Class ; rdfs:label "Generalized cerebral atrophy/hypoplasia" ; rdfs:subClassOf obo:HP_0002059 . obo:HP_0007063 oboInOwl:hasDbXref "UMLS:C1857787" ; oboInOwl:hasExactSynonym "Absent inferior half of the cerebellar vermis" ; oboInOwl:id "HP:0007063" ; a owl:Class ; rdfs:label "Aplasia of the inferior half of the cerebellar vermis" ; rdfs:subClassOf obo:HP_0006817 . obo:HP_0007064 obo:IAO_0000115 "Progressive loss of previously present language abilities." ; oboInOwl:hasDbXref "UMLS:C1843793" ; oboInOwl:id "HP:0007064" ; a owl:Class ; rdfs:label "Progressive language deterioration" ; rdfs:subClassOf obo:HP_0002344 . obo:HP_0007065 oboInOwl:hasDbXref "UMLS:C1845369" ; oboInOwl:hasExactSynonym "Disorganisation of the anterior cerebellar vermis" ; oboInOwl:id "HP:0007065" ; a owl:Class ; rdfs:label "Disorganization of the anterior cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334 . obo:HP_0007066 obo:IAO_0000115 "Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in the proximal limb muscle." ; oboInOwl:hasDbXref "UMLS:C1861460" ; oboInOwl:id "HP:0007066" ; a owl:Class ; rdfs:comment "Removed logical definition that used an anonymous class. Requested new term in UBERON: proximal musculature of limb" ; rdfs:label "Proximal limb muscle stiffness" ; rdfs:subClassOf obo:HP_0003552, obo:HP_0009127 . obo:HP_0007067 obo:IAO_0000115 "Peripheral sensory neuropathy affecting primarily distal sensation." ; oboInOwl:hasDbXref "UMLS:C4021582" ; oboInOwl:hasExactSynonym "Peripheral sensory neuropathy, distal" ; oboInOwl:id "HP:0007067" ; a owl:Class ; rdfs:label "Distal peripheral sensory neuropathy" ; rdfs:subClassOf obo:HP_0000763 . obo:HP_0007068 obo:IAO_0000115 "Underdevelopment of the inferior portion of the vermis of cerebellum." ; oboInOwl:hasAlternativeId "HP:0005724" ; oboInOwl:hasDbXref "UMLS:C1855350" ; oboInOwl:hasExactSynonym "Hypoplasia of inferior vermis", "Inferior vermis hypoplasia" ; oboInOwl:id "HP:0007068" ; a owl:Class ; rdfs:label "Inferior cerebellar vermis hypoplasia" ; rdfs:subClassOf obo:HP_0001320 . obo:HP_0007069 oboInOwl:hasDbXref "UMLS:C4024944" ; oboInOwl:id "HP:0007069" ; a owl:Class ; rdfs:label "Profound static encephalopathy" ; rdfs:subClassOf obo:HP_0007030 . obo:HP_0007074 obo:IAO_0000115 "Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain." ; oboInOwl:hasAlternativeId "HP:0006805", "HP:0006807", "HP:0200009", "HP:0200010" ; oboInOwl:hasDbXref "UMLS:C1835194" ; oboInOwl:hasExactSynonym "Abnormal size of corpus callosum", "Large corpus callosum" ; oboInOwl:id "HP:0007074" ; a owl:Class ; rdfs:label "Thick corpus callosum" ; rdfs:subClassOf obo:HP_0001273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007076 obo:IAO_0000115 "Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement)." ; oboInOwl:hasDbXref "UMLS:C1852470" ; oboInOwl:id "HP:0007076" ; a owl:Class ; rdfs:comment "This is a classic type of extrapyramidal movement disorder." ; rdfs:label "Extrapyramidal muscular rigidity" ; rdfs:subClassOf obo:HP_0002063, obo:HP_0002071 . obo:HP_0007078 obo:IAO_0000115 "A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies." ; oboInOwl:hasDbXref "UMLS:C4024943" ; oboInOwl:id "HP:0007078" ; a owl:Class ; rdfs:label "Decreased amplitude of sensory action potentials" ; rdfs:subClassOf obo:HP_0030179 . obo:HP_0007081 oboInOwl:hasDbXref "UMLS:C4024942" ; oboInOwl:id "HP:0007081" ; a owl:Class ; rdfs:label "Late-onset muscular dystrophy" ; rdfs:subClassOf obo:HP_0003560 . obo:HP_0007082 obo:IAO_0000115 "An increase in size of the third ventricle." ; oboInOwl:hasDbXref "UMLS:C4024941" ; oboInOwl:id "HP:0007082" ; a owl:Class ; rdfs:comment "The thrid ventricle is midline between the two lateral ventricles, and it communicates between them and the fourth ventricle." ; rdfs:label "Dilated third ventricle" ; rdfs:subClassOf obo:HP_0002119, obo:HP_0010951 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007083 oboInOwl:hasDbXref "UMLS:C0240116" ; oboInOwl:hasExactSynonym "Hyperreflexia in knees", "Overactive knee reflex" ; oboInOwl:hasRelatedSynonym "Brisk knee jerk" ; oboInOwl:id "HP:0007083" ; a owl:Class ; rdfs:label "Hyperactive patellar reflex" ; rdfs:subClassOf obo:HP_0002395, obo:HP_0007054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007086 oboInOwl:hasDbXref "UMLS:C1866986" ; oboInOwl:id "HP:0007086" ; a owl:Class ; rdfs:label "Social and occupational deterioration" ; rdfs:subClassOf obo:HP_0001268 . obo:HP_0007087 obo:IAO_0100001 "HP:0001336" ; oboInOwl:id "HP:0007087" ; a owl:Class ; rdfs:label "obsolete Involuntary jerking movements" ; owl:deprecated true . obo:HP_0007089 obo:IAO_0000115 "Fasciculations affecting the tongue muscle and the musculature of the face." ; oboInOwl:hasDbXref "UMLS:C1862359" ; oboInOwl:id "HP:0007089" ; a owl:Class ; rdfs:label "Facial-lingual fasciculations" ; rdfs:subClassOf obo:HP_0002380, obo:HP_0010546 . obo:HP_0007095 obo:IAO_0100001 "HP:0012650" ; oboInOwl:id "HP:0007095" ; a owl:Class ; rdfs:label "obsolete Frontoparietal polymicrogyria" ; owl:deprecated true . obo:HP_0007096 oboInOwl:hasDbXref "UMLS:C1856654" ; oboInOwl:hasExactSynonym "Underdeveloped optic tract" ; oboInOwl:id "HP:0007096" ; a owl:Class ; rdfs:label "Hypoplasia of the optic tract" ; rdfs:subClassOf obo:HP_0011000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007097 oboInOwl:hasDbXref "UMLS:C4024940" ; oboInOwl:id "HP:0007097" ; a owl:Class ; rdfs:label "Cranial nerve motor loss" ; rdfs:subClassOf obo:HP_0001291 . obo:HP_0007098 obo:IAO_0000115 "Episodes of choreoathetosis that can occur following triggers such as quick voluntary movements." ; oboInOwl:hasAlternativeId "HP:0002351" ; oboInOwl:hasDbXref "SNOMEDCT_US:49949003", "UMLS:C1851936" ; oboInOwl:hasExactSynonym "Choreoathetosis, episodic", "Choreoathetosis, intermittent" ; oboInOwl:id "HP:0007098" ; a owl:Class ; rdfs:label "Paroxysmal choreoathetosis" ; rdfs:subClassOf obo:HP_0001266 . obo:HP_0007099 obo:IAO_0000115 "Arnold-Chiari type I malformation refers to a relatively mild degree of herniation of the posteroinferior region of the cerebellum (the cerebellar tonsils) into the cervical canal with little or no displacement of the fourth ventricle. It is characterized by one or both pointed (not rounded) cerebellar tonsils that project 5 mm below the foramen magnum, measured by a line drawn from the basion to the opisthion (McRae Line)" ; oboInOwl:hasAlternativeId "HP:0002440" ; oboInOwl:hasDbXref "MSH:D001139", "SNOMEDCT_US:253185002", "UMLS:C0750929" ; oboInOwl:hasExactSynonym "Arnold Chiari type I malformation", "Arnold-Chiari type I malformation", "Chiari I malformation" ; oboInOwl:id "HP:0007099" ; a owl:Class ; rdfs:label "Chiari type I malformation" ; rdfs:subClassOf obo:HP_0002308 . obo:HP_0007100 oboInOwl:hasDbXref "UMLS:C1865119" ; oboInOwl:id "HP:0007100" ; a owl:Class ; rdfs:label "Progressive ventriculomegaly" ; rdfs:subClassOf obo:HP_0002119 . obo:HP_0007103 obo:IAO_0000115 "A darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0006804" ; oboInOwl:hasDbXref "UMLS:C4020908" ; oboInOwl:hasExactSynonym "White matter hypointensities on MRI" ; oboInOwl:id "HP:0007103" ; a owl:Class ; rdfs:label "Hypointensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0007104 oboInOwl:hasDbXref "UMLS:C4024939" ; oboInOwl:id "HP:0007104" ; a owl:Class ; rdfs:label "Prolonged somatosensory evoked potentials" ; rdfs:subClassOf obo:HP_0007377 . obo:HP_0007105 obo:IAO_0000115 "Encephalopathy with onset in the infantile period." ; oboInOwl:hasAlternativeId "HP:0006948", "HP:0007309", "HP:0007353" ; oboInOwl:hasDbXref "UMLS:C1856408" ; oboInOwl:id "HP:0007105" ; a owl:Class ; rdfs:label "Infantile encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0007107 obo:IAO_0000115 "A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4024938" ; oboInOwl:id "HP:0007107" ; a owl:Class ; rdfs:label "Segmental peripheral demyelination" ; rdfs:subClassOf obo:HP_0011096 . obo:HP_0007108 obo:IAO_0000115 "Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies." ; oboInOwl:hasAlternativeId "HP:0007205" ; oboInOwl:hasDbXref "SNOMEDCT_US:23414001", "UMLS:C0270922" ; oboInOwl:id "HP:0007108" ; a owl:Class ; rdfs:label "Demyelinating peripheral neuropathy" ; rdfs:subClassOf obo:HP_0009830, obo:HP_0012447 . obo:HP_0007109 oboInOwl:hasDbXref "UMLS:C1839858" ; oboInOwl:id "HP:0007109" ; a owl:Class ; rdfs:label "Periventricular cysts" ; rdfs:subClassOf obo:HP_0002518, obo:HP_0010576 . obo:HP_0007110 oboInOwl:hasDbXref "UMLS:C3805839" ; oboInOwl:id "HP:0007110" ; a owl:Class ; rdfs:label "Central hypoventilation" ; rdfs:subClassOf obo:HP_0002791 . obo:HP_0007111 oboInOwl:hasDbXref "UMLS:C4024937" ; oboInOwl:id "HP:0007111" ; a owl:Class ; rdfs:label "Chronic hepatic encephalopathy" ; rdfs:subClassOf obo:HP_0002480 . obo:HP_0007112 obo:IAO_0000115 "Atrophy of the temporal cortex." ; oboInOwl:hasDbXref "UMLS:C4024936" ; oboInOwl:id "HP:0007112" ; a owl:Class ; rdfs:label "Temporal cortical atrophy" ; rdfs:subClassOf obo:HP_0002120 . obo:HP_0007115 oboInOwl:hasDbXref "SNOMEDCT_US:15671007", "UMLS:C0271330" ; oboInOwl:id "HP:0007115" ; a owl:Class ; rdfs:label "Orbital encephalocele" ; rdfs:subClassOf obo:HP_0002084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007117 oboInOwl:hasDbXref "UMLS:C1838868" ; oboInOwl:id "HP:0007117" ; a owl:Class ; rdfs:label "Corticospinal tract atrophy" ; rdfs:subClassOf obo:HP_0007372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007123 obo:IAO_0000115 "A particular type of dementia characterized by a pattern of mental defects consisting prominently of forgetfulness, slowness of thought processes, and personality or mood change." ; oboInOwl:hasDbXref "UMLS:C4024935" ; oboInOwl:id "HP:0007123" ; a owl:Class ; rdfs:label "Subcortical dementia" ; rdfs:subClassOf obo:HP_0000726 . obo:HP_0007126 obo:IAO_0000115 "Amyotrophy (muscular atrophy) affecting the proximal musculature." ; oboInOwl:hasAlternativeId "HP:0006792", "HP:0006966", "HP:0008943", "HP:0008980", "HP:0009041" ; oboInOwl:hasDbXref "UMLS:C1850794" ; oboInOwl:hasExactSynonym "Muscle atrophy, proximal", "Proximal muscle atrophy", "Proximal muscle wasting", "Symmetric proximal muscular atrophy", "Symmetrical, proximal limb muscle atrophy", "Wasting of muscles near the body" ; oboInOwl:id "HP:0007126" ; a owl:Class ; rdfs:comment "Proximal amyotrophy usually has a roughly symmetric distribution." ; rdfs:label "Proximal amyotrophy" ; rdfs:subClassOf obo:HP_0003202 . obo:HP_0007129 oboInOwl:hasDbXref "UMLS:C4024934" ; oboInOwl:id "HP:0007129" ; a owl:Class ; rdfs:label "Cerebellar medulloblastoma" ; rdfs:subClassOf obo:HP_0002885 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002885 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007131 obo:IAO_0000115 "Acute progressive areflexic weakness and mild sensory changes resulting from myelin breakdown and axonal degeneration." ; oboInOwl:hasDbXref "UMLS:C4024933" ; oboInOwl:id "HP:0007131" ; a owl:Class ; rdfs:comment "This is a bundled term used to refer to the symptomatology associated with the Guillain-Barre syndrome." ; rdfs:label "Acute demyelinating polyneuropathy" ; rdfs:subClassOf obo:HP_0007108 . obo:HP_0007132 obo:IAO_0000115 "Neurodegeneration involving the globus pallidus,a part of the basal ganglia that is involved in the regulation of voluntary movement." ; oboInOwl:hasDbXref "SNOMEDCT_US:230302004", "UMLS:C0393577" ; oboInOwl:id "HP:0007132" ; a owl:Class ; rdfs:label "Pallidal degeneration" ; rdfs:subClassOf obo:HP_0002453, obo:HP_0012157 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001875 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007133 oboInOwl:hasAlternativeId "HP:0007329" ; oboInOwl:hasDbXref "UMLS:C1859178" ; oboInOwl:hasExactSynonym "Progressive polyneuropathy" ; oboInOwl:id "HP:0007133" ; a owl:Class ; rdfs:label "Progressive peripheral neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0007141 oboInOwl:hasAlternativeId "HP:0007055", "HP:0007237" ; oboInOwl:hasDbXref "UMLS:C1112256" ; oboInOwl:hasExactSynonym "Mixed polyneuropathy", "Nerve damage causing decreased feeling and movement", "Sensorimotor peripheral neuropathy" ; oboInOwl:id "HP:0007141" ; a owl:Class ; rdfs:label "Sensorimotor neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0007146 oboInOwl:hasDbXref "UMLS:C4024932" ; oboInOwl:id "HP:0007146" ; a owl:Class ; rdfs:label "Bilateral basal ganglia lesions" ; rdfs:subClassOf obo:HP_0002134 . obo:HP_0007149 obo:IAO_0000115 "Muscular atrophy of distal arm muscles." ; oboInOwl:hasDbXref "UMLS:C4021581" ; oboInOwl:hasExactSynonym "Distal upper limb muscle atrophy" ; oboInOwl:id "HP:0007149" ; a owl:Class ; rdfs:label "Distal upper limb amyotrophy" ; rdfs:subClassOf obo:HP_0003693, obo:HP_0009129 . obo:HP_0007153 oboInOwl:hasDbXref "UMLS:C2748610" ; oboInOwl:id "HP:0007153" ; a owl:Class ; rdfs:label "Progressive extrapyramidal movement disorder" ; rdfs:subClassOf obo:HP_0002071 . obo:HP_0007156 obo:IAO_0000115 "Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern." ; oboInOwl:hasDbXref "UMLS:C4024931" ; oboInOwl:id "HP:0007156" ; a owl:Class ; rdfs:label "Asymmetric limb muscle stiffness" ; rdfs:subClassOf obo:HP_0003552, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0007158 obo:IAO_0000115 "A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement)." ; oboInOwl:hasDbXref "UMLS:C4021580" ; oboInOwl:hasExactSynonym "Progressive extrapyramidal rigidity" ; oboInOwl:id "HP:0007158" ; a owl:Class ; rdfs:label "Progressive extrapyramidal muscular rigidity" ; rdfs:subClassOf obo:HP_0007076 . obo:HP_0007159 oboInOwl:hasDbXref "UMLS:C1851959" ; oboInOwl:id "HP:0007159" ; a owl:Class ; rdfs:label "Fluctuations in consciousness" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0007162 obo:IAO_0000115 "A diffuse loss of myelin from nerve fibers in the central nervous system." ; oboInOwl:hasDbXref "UMLS:C4024930" ; oboInOwl:id "HP:0007162" ; a owl:Class ; rdfs:label "Diffuse demyelination of the cerebral white matter" ; rdfs:subClassOf obo:HP_0007305 . obo:HP_0007163 oboInOwl:consider "HP:0007256" ; oboInOwl:id "HP:0007163" ; a owl:Class ; rdfs:label "obsolete Corticospinal tract disease in lower limbs" ; owl:deprecated true . obo:HP_0007164 oboInOwl:hasDbXref "UMLS:C4024929" ; oboInOwl:hasExactSynonym "Slowed slurred speech" ; oboInOwl:id "HP:0007164" ; a owl:Class ; rdfs:label "Slowed slurred speech" ; rdfs:subClassOf obo:HP_0001350 . obo:HP_0007165 obo:IAO_0000115 "A form of gray matter heterotopia were the mislocalized gray matter is typically located periventricularly, also sometimes called subependymal heterotopia. Periventricular means beside the ventricles. This is by far the most common location for heterotopia. Subependymal heterotopia present in a wide array of variations. There can be a small single node or a large number of nodes, can exist on either or both sides of the brain at any point along the higher ventricle margins, can be small or large, single or multiple, and can form a small node or a large wavy or curved mass." ; oboInOwl:hasAlternativeId "HP:0002272" ; oboInOwl:hasDbXref "UMLS:C1849173" ; oboInOwl:hasExactSynonym "Periventricular gray matter heterotopia", "Periventricular grey matter heterotopia", "Periventricular neuronal heterotopia", "Subependymal gray matter heterotopia", "Subependymal grey matter heterotopia", "Subependymal neuronal heterotopia" ; oboInOwl:id "HP:0007165" ; a owl:Class ; rdfs:comment "Periventricular gray matter heterotopia can be seen for example in patients with Smith-Lemli-Opitz-Syndrome." ; rdfs:label "Periventricular heterotopia" ; rdfs:subClassOf obo:HP_0002282 . obo:HP_0007166 obo:IAO_0000115 "Episodic bouts of involuntary movements with dystonic, choreic, ballistic movements, or a combination thereof. There is no loss of consciousness during the attacks." ; oboInOwl:hasDbXref "MSH:D002819", "UMLS:C0752210", "UMLS:C1836174" ; oboInOwl:hasRelatedSynonym "Involuntary dystonic or choreiform movements" ; oboInOwl:id "HP:0007166" ; a owl:Class ; rdfs:label "Paroxysmal dyskinesia" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 . obo:HP_0007178 oboInOwl:hasAlternativeId "HP:0007278" ; oboInOwl:hasDbXref "MSH:D009443", "MSH:D011115", "SNOMEDCT_US:85423005", "SNOMEDCT_US:95663000", "UMLS:C0235025", "UMLS:C0271683" ; oboInOwl:hasExactSynonym "Peripheral motor neuropathy" ; oboInOwl:id "HP:0007178" ; a owl:Class ; rdfs:label "Motor polyneuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0007179 obo:IAO_0000115 "A complete lack of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion." ; oboInOwl:hasDbXref "UMLS:C4024928" ; oboInOwl:id "HP:0007179" ; a owl:Class ; rdfs:label "Absent smooth pursuit" ; rdfs:subClassOf obo:HP_0007772 . obo:HP_0007181 obo:IAO_0000115 "Atrophy of the interosseus muscles (including the palmar interossei that lie on the anterior aspect of the metacarpals, the dorsal interosseus muscles of the hand, which lie between the intercarpals, the plantar interosseus muscles, which lie underneath the metatarsal bones, and the dorsal interossei, which are located between the metatarsal bones." ; oboInOwl:hasDbXref "UMLS:C1846829" ; oboInOwl:hasExactSynonym "Interosseous muscular atrophy" ; oboInOwl:id "HP:0007181" ; a owl:Class ; rdfs:comment "This term needs disambiguation. Palmar, plantar, or dorsal interosseus muscles." ; rdfs:label "Interosseus muscle atrophy" ; rdfs:subClassOf obo:HP_0003693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007182 obo:IAO_0000115 "Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the peripheral nervous system." ; oboInOwl:hasAlternativeId "HP:0007012", "HP:0007160", "HP:0007226" ; oboInOwl:hasDbXref "UMLS:C4024927" ; oboInOwl:id "HP:0007182" ; a owl:Class ; rdfs:comment "This finding can be demonstrated by nerve biopsy." ; rdfs:label "Peripheral hypomyelination" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000345 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007183 obo:IAO_0000115 "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hyperintensity affecting a particular region of the basal ganglia." ; oboInOwl:hasDbXref "UMLS:C1865351", "UMLS:C4024926" ; oboInOwl:hasRelatedSynonym "Hyperintense lesions in the basal ganglia on MRI" ; oboInOwl:id "HP:0007183" ; a owl:Class ; rdfs:label "Focal T2 hyperintense basal ganglia lesion" ; rdfs:subClassOf obo:HP_0012751 . obo:HP_0007185 oboInOwl:hasDbXref "MSH:D014474", "SNOMEDCT_US:418107008", "SNOMEDCT_US:419045004", "UMLS:C0041657" ; oboInOwl:hasExactSynonym "Loss of consciousness", "Passing out" ; oboInOwl:id "HP:0007185" ; a owl:Class ; rdfs:label "Loss of consciousness" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0007187 obo:IAO_0000115 "A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure that affects a particular part of the cortex." ; oboInOwl:hasDbXref "UMLS:C1855230" ; oboInOwl:id "HP:0007187" ; a owl:Class ; rdfs:label "Focal lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0007188 obo:IAO_0000115 "Facial diplegia (that is, bilateral facial palsy) with congenital onset." ; oboInOwl:hasDbXref "MSH:C531747", "UMLS:C0853240" ; oboInOwl:hasExactSynonym "Congenital bilateral facial palsy", "Congenital bilateral facial weakness" ; oboInOwl:id "HP:0007188" ; a owl:Class ; rdfs:label "Congenital facial diplegia" ; rdfs:subClassOf obo:HP_0001349 . obo:HP_0007190 oboInOwl:hasDbXref "UMLS:C1849485" ; oboInOwl:id "HP:0007190" ; a owl:Class ; rdfs:label "Neuronal loss in the cerebral cortex" ; rdfs:subClassOf obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007193 obo:IAO_0000115 "Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day)." ; oboInOwl:hasAlternativeId "HP:0007008" ; oboInOwl:hasDbXref "UMLS:C1847165" ; oboInOwl:hasExactSynonym "Generalised tonic-clonic seizures on awakening", "Generalized tonic-clonic seizures on awakening", "Morning generalised tonic-clonic seizures", "Morning generalized tonic-clonic seizures" ; oboInOwl:id "HP:0007193" ; a owl:Class ; rdfs:label "Bilateral tonic-clonic seizure on awakening" ; rdfs:subClassOf obo:HP_0002069 . obo:HP_0007199 oboInOwl:hasDbXref "UMLS:C0747251" ; oboInOwl:id "HP:0007199" ; a owl:Class ; rdfs:label "Progressive spastic paraparesis" ; rdfs:subClassOf obo:HP_0002313 . obo:HP_0007200 oboInOwl:hasDbXref "UMLS:C4024925" ; oboInOwl:id "HP:0007200" ; a owl:Class ; rdfs:label "Episodic hypersomnia" ; rdfs:subClassOf obo:HP_0004372, obo:HP_0100786 . obo:HP_0007201 obo:IAO_0000115 "The formation of the formation of fibrofatty lesions in the wall of an artery located in the brain." ; oboInOwl:hasBroadSynonym "Plaque build-up in cerebral artery" ; oboInOwl:hasDbXref "UMLS:C4024924" ; oboInOwl:id "HP:0007201" ; a owl:Class ; rdfs:label "Cerebral artery atherosclerosis" ; rdfs:subClassOf obo:HP_0002621, obo:HP_0009145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_28 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007204 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4024923" ; oboInOwl:id "HP:0007204" ; a owl:Class ; rdfs:comment "This finding is demonstrated by cerebral computer tomography or magnetic resonance imaging." ; rdfs:label "Diffuse white matter abnormalities" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0007206 obo:IAO_0000115 "Enlargement of all or parts of one cerebral hemisphere." ; oboInOwl:hasDbXref "MSH:D065705", "SNOMEDCT_US:253170008", "UMLS:C0431391" ; oboInOwl:id "HP:0007206" ; a owl:Class ; rdfs:comment "The affected hemisphere may have focal or diffuse neuronal migration defects, with areas of polymicrogyria, pachygyria, and heterotopia." ; rdfs:label "Hemimegalencephaly" ; rdfs:subClassOf obo:HP_0001355 . obo:HP_0007207 obo:IAO_0000115 "Generalized-onset tonic-clonic seizures that are provoked by flashing or flickering light." ; oboInOwl:hasDbXref "UMLS:C1846131" ; oboInOwl:hasExactSynonym "Photically induced tonic-clonic seizure", "Photosensitive tonic-clonic seizures", "Seizures, tonic-clonic, photosensitive" ; oboInOwl:id "HP:0007207" ; a owl:Class ; rdfs:label "Photosensitive tonic-clonic seizure" ; rdfs:subClassOf obo:HP_0020216, obo:HP_0025190 . obo:HP_0007208 obo:IAO_0000115 "Presence of irregular redundant loops of focally folded myelin in a peripheral nerve." ; oboInOwl:hasDbXref "UMLS:C4024922" ; oboInOwl:id "HP:0007208" ; a owl:Class ; rdfs:label "Irregular myelin loops" ; rdfs:subClassOf obo:HP_0030173 . obo:HP_0007209 obo:IAO_0000115 "Complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve)." ; oboInOwl:hasAlternativeId "HP:0007358" ; oboInOwl:hasDbXref "MSH:D005158", "SNOMEDCT_US:280816001", "SNOMEDCT_US:95666008", "UMLS:C0015469", "UMLS:C0427055" ; oboInOwl:hasExactSynonym "Facial paralysis", "Facial paresis" ; oboInOwl:id "HP:0007209" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Facial paralysis can be caused by compression of the facial nerve.The main difference between facial paralysis and Palsy is cause for the paralysis can be identified, be it a tumor, infection, or nerve damage. Facial paralysis, in most cases, also appears more permanent than Bell's Palsy, with cases lasting for years to life if a patient doesn't seek treatment." ; rdfs:label "Facial paralysis" ; rdfs:subClassOf obo:HP_0001293, obo:HP_0003470, obo:HP_0030319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007210 obo:IAO_0000115 "Muscular atrophy affecting the lower limb." ; oboInOwl:hasDbXref "UMLS:C4024921" ; oboInOwl:id "HP:0007210" ; a owl:Class ; rdfs:label "Lower limb amyotrophy" ; rdfs:subClassOf obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004482 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007215 obo:IAO_0000115 "Episodes of muscle weakness associated with elevated levels of potassium in the blood." ; oboInOwl:hasDbXref "MSH:D020513", "SNOMEDCT_US:304737009", "UMLS:C0238357" ; oboInOwl:hasExactSynonym "Hyperkalemic periodic paralysis" ; oboInOwl:id "HP:0007215" ; a owl:Class ; rdfs:label "Periodic hyperkalemic paralysis" ; rdfs:subClassOf obo:HP_0003768 . obo:HP_0007220 obo:IAO_0000115 "Demyelination of peripheral motor nerves." ; oboInOwl:hasDbXref "UMLS:C1969462" ; oboInOwl:id "HP:0007220" ; a owl:Class ; rdfs:comment "Demyelinating motor neuropathy demonstrates slow motor nerve conduction velocities with reduced amplitudes of motor nerve conduction and prolonged distal latencies." ; rdfs:label "Demyelinating motor neuropathy" ; rdfs:subClassOf obo:HP_0007108, obo:HP_0007178 . obo:HP_0007221 oboInOwl:hasDbXref "UMLS:C1849143" ; oboInOwl:id "HP:0007221" ; a owl:Class ; rdfs:label "Progressive truncal ataxia" ; rdfs:subClassOf obo:HP_0002078 . obo:HP_0007227 obo:IAO_0000115 "Increased size of cerebral gyri, often associated with a moderate reduction in the number of sulci of the cerebrum." ; oboInOwl:hasDbXref "MSH:D054082", "SNOMEDCT_US:23024003", "UMLS:C0266483" ; oboInOwl:id "HP:0007227" ; a owl:Class ; rdfs:label "Macrogyria" ; rdfs:subClassOf obo:HP_0002536 . obo:HP_0007229 obo:IAO_0000115 "The presence of calcium deposition in the cerebral white matter surrounding the cerebral ventricles." ; oboInOwl:hasDbXref "UMLS:C1837246" ; oboInOwl:id "HP:0007229" ; a owl:Class ; rdfs:label "Intracerebral periventricular calcifications" ; rdfs:subClassOf obo:HP_0002514 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0007230 obo:IAO_0000115 "A reduction in the amplitude of sensory nerve action potential in distal nerve segments. This feature is measured by nerve conduction studies." ; oboInOwl:hasDbXref "UMLS:C4024920" ; oboInOwl:id "HP:0007230" ; a owl:Class ; rdfs:label "Decreased distal sensory nerve action potential" ; rdfs:subClassOf obo:HP_0007078 . obo:HP_0007232 oboInOwl:hasDbXref "UMLS:C4024919" ; oboInOwl:id "HP:0007232" ; a owl:Class ; rdfs:label "Spinocerebellar tract disease in lower limbs" ; rdfs:subClassOf obo:HP_0002503 . obo:HP_0007233 obo:IAO_0000115 "Groups of small caliber axons in peripheral nerve biospies indicative of axonal regeneration." ; oboInOwl:hasDbXref "UMLS:C1843169" ; oboInOwl:id "HP:0007233" ; a owl:Class ; rdfs:label "Clusters of axonal regeneration" ; rdfs:subClassOf obo:HP_0003450 . obo:HP_0007236 oboInOwl:hasDbXref "UMLS:C4024918" ; oboInOwl:id "HP:0007236" ; a owl:Class ; rdfs:label "Recurrent subcortical infarcts" ; rdfs:subClassOf obo:HP_0010993 . obo:HP_0007238 oboInOwl:hasDbXref "UMLS:C4021579" ; oboInOwl:hasExactSynonym "Cerebral calcification, nonarteriosclerotic" ; oboInOwl:id "HP:0007238" ; a owl:Class ; rdfs:label "Nonarteriosclerotic cerebral calcification" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0007239 oboInOwl:hasDbXref "UMLS:C4024917" ; oboInOwl:id "HP:0007239" ; a owl:Class ; rdfs:label "Congenital encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0007240 obo:IAO_0000115 "A type of gait ataxia displaying progression of clinical severity." ; oboInOwl:hasAlternativeId "HP:0002142" ; oboInOwl:hasDbXref "UMLS:C1843885" ; oboInOwl:hasExactSynonym "Gait ataxia, progressive" ; oboInOwl:id "HP:0007240" ; a owl:Class ; rdfs:label "Progressive gait ataxia" ; rdfs:subClassOf obo:HP_0002066 . obo:HP_0007249 oboInOwl:hasDbXref "UMLS:C4024916" ; oboInOwl:hasExactSynonym "Decreased number of small peripheral myelinated nerve fibres" ; oboInOwl:id "HP:0007249" ; a owl:Class ; rdfs:label "Decreased number of small peripheral myelinated nerve fibers" ; rdfs:subClassOf obo:HP_0003380 . obo:HP_0007250 obo:IAO_0000115 "Alternating and recurrent weakness of the external ocular muscles." ; oboInOwl:hasDbXref "UMLS:C4024915" ; oboInOwl:id "HP:0007250" ; a owl:Class ; rdfs:label "Recurrent external ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000544 . obo:HP_0007256 obo:IAO_0000115 "Functional neurological abnormalities related to dysfunction of the pyramidal tract." ; oboInOwl:hasAlternativeId "HP:0003488", "HP:0007161", "HP:0007225", "HP:0007275", "HP:0007324", "HP:0007347" ; oboInOwl:hasDbXref "SNOMEDCT_US:14648003", "UMLS:C0234132" ; oboInOwl:hasExactSynonym "Corticospinal signs", "Pyramidal signs", "Pyramidal tract signs" ; oboInOwl:id "HP:0007256" ; a owl:Class ; rdfs:comment "Presence of these signs can indicate affection of the corticospinal (pyramidal) tracts." ; rdfs:label "Abnormal pyramidal sign" ; rdfs:subClassOf obo:HP_0002493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007258 obo:IAO_0000115 "A severe loss of myelin from nerve fibers in the central nervous system." ; oboInOwl:hasDbXref "UMLS:C1856001" ; oboInOwl:id "HP:0007258" ; a owl:Class ; rdfs:label "Severe demyelination of the white matter" ; rdfs:subClassOf obo:HP_0007305 . obo:HP_0007260 obo:IAO_0000115 "A form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers." ; oboInOwl:hasAlternativeId "HP:0006853" ; oboInOwl:hasDbXref "MSH:D054222", "SNOMEDCT_US:253149002", "UMLS:C0431376" ; oboInOwl:hasExactSynonym "Cobblestone lissencephaly", "Lissencephaly type II", "Type 2 lissencephaly" ; oboInOwl:id "HP:0007260" ; a owl:Class ; rdfs:label "Type II lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0007262 obo:IAO_0000115 "A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4024914" ; oboInOwl:id "HP:0007262" ; a owl:Class ; rdfs:label "Symmetric peripheral demyelination" ; rdfs:subClassOf obo:HP_0011096 . obo:HP_0007263 obo:IAO_0000115 "Atrophy affecting the cerebellum and the spinocerebellar tracts of the spinal cord." ; oboInOwl:hasDbXref "MSH:D020754", "SNOMEDCT_US:129609000", "UMLS:C0087012" ; oboInOwl:id "HP:0007263" ; a owl:Class ; rdfs:label "Spinocerebellar atrophy" ; rdfs:subClassOf obo:HP_0001272 . obo:HP_0007265 obo:IAO_0000115 "Agenesis of the midbrain." ; oboInOwl:hasDbXref "UMLS:C4024913" ; oboInOwl:id "HP:0007265" ; a owl:Class ; rdfs:comment "Midbrain and mesencephalon are synonymous." ; rdfs:label "Absent mesencephalon" ; rdfs:subClassOf obo:HP_0034258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001891 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007266 obo:IAO_0000115 "Defective structure and function of myelin sheaths of the white matter of the brain." ; oboInOwl:hasAlternativeId "HP:0007134", "HP:0007217" ; oboInOwl:hasDbXref "UMLS:C1854885", "UMLS:C4020810" ; oboInOwl:hasExactSynonym "Areas of dysmyelination on MRI", "Dysmyelination of the brain" ; oboInOwl:hasRelatedSynonym "White matter dysmyelination/demyelination" ; oboInOwl:id "HP:0007266" ; a owl:Class ; rdfs:label "Cerebral dysmyelination" ; rdfs:subClassOf obo:HP_0002500, obo:HP_0011400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032289 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007267 obo:IAO_0000115 "An abnormality characterized by chronic impairment of the normal functioning of the axons." ; oboInOwl:hasAlternativeId "HP:0003446" ; oboInOwl:hasDbXref "UMLS:C4021578" ; oboInOwl:hasExactSynonym "Chronic sural axonal neuropathy" ; oboInOwl:id "HP:0007267" ; a owl:Class ; rdfs:comment "This feature is assayed with sural nerve biopsy and is generally taken to be indicative of neuropathy in other peripheral nerves." ; rdfs:label "Chronic axonal neuropathy" ; rdfs:subClassOf obo:HP_0003477 . obo:HP_0007268 oboInOwl:hasDbXref "MSH:D000757", "SNOMEDCT_US:277922001", "UMLS:C0431349" ; oboInOwl:id "HP:0007268" ; a owl:Class ; rdfs:label "Aprosencephaly" ; rdfs:subClassOf obo:HP_0007364 . obo:HP_0007269 obo:IAO_0000115 "Muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." ; oboInOwl:hasDbXref "MSH:D009134", "SNOMEDCT_US:5262007", "UMLS:C0026847" ; oboInOwl:hasExactSynonym "Spinal muscle degeneration", "Spinal muscle wasting" ; oboInOwl:id "HP:0007269" ; a owl:Class ; rdfs:label "Spinal muscular atrophy" ; rdfs:subClassOf obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001999 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007270 obo:IAO_0000115 "An atypical absence seizure is a type of generalised non-motor (absence) seizure characterised by interruption of ongoing activities and reduced responsiveness. In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity." ; oboInOwl:hasDbXref "SNOMEDCT_US:23374007", "UMLS:C0595948" ; oboInOwl:hasExactSynonym "Atypical absence", "Atypical absence seizures", "Atypical petit mal seizures" ; oboInOwl:id "HP:0007270" ; a owl:Class ; rdfs:comment "in 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (over 80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination; see Dialeptic seizure." ; rdfs:label "Atypical absence seizure" ; rdfs:subClassOf obo:HP_0002121 . obo:HP_0007271 oboInOwl:hasDbXref "UMLS:C4024912" ; oboInOwl:id "HP:0007271" ; a owl:Class ; rdfs:label "Occipital myelomeningocele" ; rdfs:subClassOf obo:HP_0002436 . obo:HP_0007272 oboInOwl:hasAlternativeId "HP:0006856" ; oboInOwl:hasDbXref "UMLS:C1856565" ; oboInOwl:hasExactSynonym "Progressive mental and motor deterioration" ; oboInOwl:id "HP:0007272" ; a owl:Class ; rdfs:label "Progressive psychomotor deterioration" ; rdfs:subClassOf obo:HP_0002344 . obo:HP_0007274 obo:IAO_0000115 "An increased susceptibility to bacterial meningitis as manifested by a medical history of recurrent episodes of bacterial meningitis." ; oboInOwl:hasDbXref "UMLS:C1845604" ; oboInOwl:id "HP:0007274" ; a owl:Class ; rdfs:label "Recurrent bacterial meningitis" ; rdfs:subClassOf obo:HP_0006946 . obo:HP_0007277 oboInOwl:hasDbXref "UMLS:C2673351" ; oboInOwl:id "HP:0007277" ; a owl:Class ; rdfs:label "Paucity of anterior horn motor neurons" ; rdfs:subClassOf obo:HP_0002450 . obo:HP_0007280 oboInOwl:hasDbXref "UMLS:C4024911" ; oboInOwl:id "HP:0007280" ; a owl:Class ; rdfs:label "Acute infantile spinal muscular atrophy" ; rdfs:subClassOf obo:HP_0007269 . obo:HP_0007281 obo:IAO_0000115 "A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills." ; oboInOwl:hasAlternativeId "HP:0007130", "HP:0007198" ; oboInOwl:hasDbXref "UMLS:C1848980" ; oboInOwl:hasExactSynonym "Developmental arrest" ; oboInOwl:id "HP:0007281" ; a owl:Class ; rdfs:label "Developmental stagnation" ; rdfs:subClassOf obo:HP_0012759 . obo:HP_0007285 obo:IAO_0000115 "Paralysis of the facial nerves on the basis of overgrowth of the cranial bones causing impingement upon the seventh cranial nerve." ; oboInOwl:hasDbXref "UMLS:C1849260" ; oboInOwl:hasExactSynonym "Facial palsy caused by enlargement of cranial bones", "Facial palsy caused by excessive growth of facial bones", "Facial palsy caused by overgrowth of cranial bones", "Facial palsy secondary to hypertrophy of cranial bones" ; oboInOwl:id "HP:0007285" ; a owl:Class ; rdfs:label "Facial palsy secondary to cranial hyperostosis" ; rdfs:subClassOf obo:HP_0005465 . obo:HP_0007286 obo:IAO_0000115 "Nystagmus consisting of horizontal to-and-fro eye movements, in which the movement in one direction is faster than in the other." ; oboInOwl:hasDbXref "UMLS:C4024910" ; oboInOwl:id "HP:0007286" ; a owl:Class ; rdfs:comment "Pendular nystagmus refers to the situation in which the eye appeared to oscillate with equal speed in either direction, in contrast to jerk nystagmus, in which the movement in one direction is faster than in the other." ; rdfs:label "Horizontal jerk nystagmus" ; rdfs:subClassOf obo:HP_0000666 . obo:HP_0007289 obo:IAO_0000115 "Fasciculations affecting the musculature of the arms and legs." ; oboInOwl:hasAlternativeId "HP:0007049" ; oboInOwl:hasDbXref "UMLS:C1854657" ; oboInOwl:hasExactSynonym "Limb fasciculation" ; oboInOwl:id "HP:0007289" ; a owl:Class ; rdfs:label "Limb fasciculations" ; rdfs:subClassOf obo:HP_0002380, obo:HP_0010546, obo:HP_0040064 . obo:HP_0007291 obo:IAO_0000115 "A discrete posterior fossa cerebrospinal fluid (CSF) collection that does not communicate directly with the fourth ventricle." ; oboInOwl:hasAlternativeId "HP:0006985" ; oboInOwl:hasDbXref "UMLS:C1857353" ; oboInOwl:id "HP:0007291" ; a owl:Class ; rdfs:label "Posterior fossa cyst" ; rdfs:subClassOf obo:HP_0000932, obo:HP_0010576 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008788 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007293 oboInOwl:hasDbXref "UMLS:C1867776" ; oboInOwl:id "HP:0007293" ; a owl:Class ; rdfs:label "Anterior sacral meningocele" ; rdfs:subClassOf obo:HP_0005765 . obo:HP_0007295 oboInOwl:hasDbXref "UMLS:C4024909" ; oboInOwl:id "HP:0007295" ; a owl:Class ; rdfs:label "Chaotic rapid conjugate ocular movements" ; rdfs:subClassOf obo:HP_0012547 . obo:HP_0007299 oboInOwl:hasDbXref "UMLS:C1832671" ; oboInOwl:id "HP:0007299" ; a owl:Class ; rdfs:label "Dysfunction of lateral corticospinal tracts" ; rdfs:subClassOf obo:HP_0002493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002589 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007301 obo:IAO_0000115 "Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control." ; oboInOwl:hasDbXref "UMLS:C4021845" ; oboInOwl:hasExactSynonym "Oral-motor apraxia" ; oboInOwl:id "HP:0007301" ; a owl:Class ; rdfs:comment "Affected individuals may experience difficulty in performing movements involving the muscles that also are involved in speech (e.g., clicking the tongue, licking the lips, whistling)." ; rdfs:label "Oromotor apraxia" ; rdfs:subClassOf obo:HP_0002186 . obo:HP_0007302 oboInOwl:hasAlternativeId "HP:0000755" ; oboInOwl:hasDbXref "MSH:D001714", "SNOMEDCT_US:13746004", "UMLS:C0005586" ; oboInOwl:hasExactSynonym "Bipolar disorder" ; oboInOwl:id "HP:0007302" ; a owl:Class ; rdfs:label "Bipolar affective disorder" ; rdfs:subClassOf obo:HP_0031466, obo:HP_0100754 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000258 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007305 obo:IAO_0000115 "A loss of myelin from nerve fibers in the central nervous system." ; oboInOwl:hasAlternativeId "HP:0007222" ; oboInOwl:hasDbXref "UMLS:C0338474" ; oboInOwl:hasExactSynonym "Demyelination in central white matter" ; oboInOwl:id "HP:0007305" ; a owl:Class ; rdfs:comment "CNS demyelination affects the white matter, which consists mostly of axons with their envelope of myelin, along with two types of neuroglia: oligo-dendrocytes and astrocytes." ; rdfs:label "CNS demyelination" ; rdfs:subClassOf obo:HP_0011400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007307 oboInOwl:hasDbXref "UMLS:C4024908" ; oboInOwl:id "HP:0007307" ; a owl:Class ; rdfs:label "Rapid neurologic deterioration" ; rdfs:subClassOf obo:HP_0002344 . obo:HP_0007308 oboInOwl:hasDbXref "UMLS:C1848528" ; oboInOwl:id "HP:0007308" ; a owl:Class ; rdfs:label "Extrapyramidal dyskinesia" ; rdfs:subClassOf obo:HP_0002071, obo:HP_0100660 . obo:HP_0007311 oboInOwl:hasDbXref "UMLS:C3805715" ; oboInOwl:hasExactSynonym "Short stepped shuffling walk" ; oboInOwl:id "HP:0007311" ; a owl:Class ; rdfs:label "Short stepped shuffling gait" ; rdfs:subClassOf obo:HP_0002362 . obo:HP_0007313 oboInOwl:hasAlternativeId "HP:0006874" ; oboInOwl:hasDbXref "SNOMEDCT_US:418143002", "SNOMEDCT_US:52522001", "UMLS:C0154671" ; oboInOwl:hasExactSynonym "Neuroaxonal degeneration in the brain" ; oboInOwl:id "HP:0007313" ; a owl:Class ; rdfs:label "Cerebral degeneration" ; rdfs:subClassOf obo:HP_0007369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007314 obo:IAO_0100001 "HP:0002282" ; oboInOwl:id "HP:0007314" ; a owl:Class ; rdfs:label "obsolete White matter neuronal heterotopia" ; owl:deprecated true . obo:HP_0007316 obo:IAO_0100001 "HP:0002305" ; oboInOwl:id "HP:0007316" ; a owl:Class ; rdfs:label "obsolete Involuntary writhing movements" ; owl:deprecated true . obo:HP_0007321 obo:IAO_0000115 "Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1856979" ; oboInOwl:hasExactSynonym "Deep cerebral white matter hypodensities" ; oboInOwl:id "HP:0007321" ; a owl:Class ; rdfs:comment "See also defintion for \"Periventricular white matter hypodensities\". These two entities are in contra-distinction to each other." ; rdfs:label "Deep white matter hypodensities" ; rdfs:subClassOf obo:HP_0007103 . obo:HP_0007325 obo:IAO_0000115 "A type of dystonia that affects all or most of the body." ; oboInOwl:hasDbXref "SNOMEDCT_US:425492002", "UMLS:C1848954" ; oboInOwl:hasExactSynonym "Generalised dystonia" ; oboInOwl:id "HP:0007325" ; a owl:Class ; rdfs:label "Generalized dystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0007326 oboInOwl:hasDbXref "UMLS:C1860216" ; oboInOwl:id "HP:0007326" ; a owl:Class ; rdfs:label "Progressive choreoathetosis" ; rdfs:subClassOf obo:HP_0001266 . obo:HP_0007327 oboInOwl:hasDbXref "UMLS:C4024907" ; oboInOwl:id "HP:0007327" ; a owl:Class ; rdfs:label "Mixed demyelinating and axonal polyneuropathy" ; rdfs:subClassOf obo:HP_0009830, obo:HP_0012447 . obo:HP_0007328 obo:IAO_0000115 "Reduced ability to perceive painful stimuli." ; oboInOwl:hasAlternativeId "HP:0002713" ; oboInOwl:hasDbXref "UMLS:C1837522" ; oboInOwl:hasExactSynonym "Decreased pain sensation", "Decreased pinprick sensation", "Impaired pain sensation" ; oboInOwl:id "HP:0007328" ; a owl:Class ; rdfs:label "Impaired pain sensation" ; rdfs:subClassOf obo:HP_0010832 . obo:HP_0007330 oboInOwl:hasDbXref "MSH:D004677", "SNOMEDCT_US:253103006", "UMLS:C0431289" ; oboInOwl:id "HP:0007330" ; a owl:Class ; rdfs:label "Frontal encephalocele" ; rdfs:subClassOf obo:HP_0002084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007332 obo:IAO_0000115 "Focal seizure characterized at onset by clonic movements affecting half of the face." ; oboInOwl:hasDbXref "UMLS:C4024906" ; oboInOwl:hasExactSynonym "Hemifacial seizures" ; oboInOwl:id "HP:0007332" ; a owl:Class ; rdfs:comment "A seizure type typically occurring in childhood epilepsy with centrotemporal spikes." ; rdfs:label "Focal hemifacial clonic seizure" ; rdfs:subClassOf obo:HP_0002266 . obo:HP_0007333 obo:IAO_0000115 "Underdevelopment of the frontal lobe of the cerebrum." ; oboInOwl:hasAlternativeId "HP:0002424" ; oboInOwl:hasDbXref "UMLS:C1849172" ; oboInOwl:hasExactSynonym "Frontal lobe hypoplasia", "Hypoplastic frontal lobes", "Underdeveloped frontal lobe" ; oboInOwl:id "HP:0007333" ; a owl:Class ; rdfs:label "Hypoplasia of the frontal lobes" ; rdfs:subClassOf obo:HP_0002538, obo:HP_0006872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001870 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007334 obo:IAO_0000115 "A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase." ; oboInOwl:hasAlternativeId "HP:0002602" ; oboInOwl:hasDbXref "UMLS:C0877017" ; oboInOwl:hasExactSynonym "Focal seizure with secondary generalisation", "Focal seizure with secondary generalization", "Focal to bilateral tonic-clonic seizure", "Generalised tonic-clonic seizure with focal onset", "Generalised tonic-clonic seizure with partial onset", "Generalised tonic-clonic seizures with focal onset", "Generalized tonic-clonic seizure with focal onset", "Generalized tonic-clonic seizure with partial onset", "Generalized tonic-clonic seizures with focal onset", "Partial seizure with secondary generalisation", "Partial seizure with secondary generalization", "Partial seizures with secondary generalisation", "Partial seizures with secondary generalization", "Secondarily generalised tonic-clonic seizure", "Secondarily generalised tonic-clonic seizures", "Secondarily generalized tonic-clonic seizure", "Secondary generalised tonic clonic seizures", "Secondary generalised tonic-clonic seizures", "Secondary generalized tonic clonic seizures", "Secondary generalized tonic-clonic seizures" ; oboInOwl:id "HP:0007334" ; a owl:Class ; rdfs:comment "The ILAE 2017 classification refers to this seizure type as a focal to bilateral tonic-clonic seizure. Previously it has been known as a secondarily generalized tonic-clonic seizure. The focal features of the seizure may be clinically manifest or alternatively, the spread in brain networks may be so rapid that no preceding focal symptom or sign is identified with demonstration of the focal onset resting on investigations. Note that not all instances of a Bilateral tonic-clonic seizure with focal onset will be a Focal motor seizure, some will be a Focal non-motor seizure, thus one can only say that there is a Focal-onset." ; rdfs:label "Bilateral tonic-clonic seizure with focal onset" ; rdfs:subClassOf obo:HP_0002069, obo:HP_0007359 . obo:HP_0007335 obo:IAO_0000115 "Recurrent episodes of brain dysfunction that may be triggered by factors such as metabolic disturbances or infections." ; oboInOwl:hasAlternativeId "HP:0006947" ; oboInOwl:hasDbXref "UMLS:C1850719" ; oboInOwl:hasExactSynonym "Recurrent cerebellar and extrapyramidal encephalopathy" ; oboInOwl:id "HP:0007335" ; a owl:Class ; rdfs:label "Recurrent encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0007338 obo:IAO_0000115 "A saccade that overshoots the target with the dynamic saccade." ; oboInOwl:hasDbXref "SNOMEDCT_US:246769000", "UMLS:C0423083" ; oboInOwl:id "HP:0007338" ; a owl:Class ; rdfs:label "Hypermetric saccades" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0007340 obo:IAO_0000115 "Weakness of the muscles of the legs." ; oboInOwl:hasAlternativeId "HP:0002065", "HP:0002477", "HP:0009047" ; oboInOwl:hasDbXref "SNOMEDCT_US:249945007", "UMLS:C0427068", "UMLS:C1836296" ; oboInOwl:hasExactSynonym "Lower extremity weakness", "Lower limb muscle weakness", "Lower limb weakness", "Muscle weakness in lower limbs" ; oboInOwl:hasRelatedSynonym "Leg weakness" ; oboInOwl:id "HP:0007340" ; a owl:Class ; rdfs:comment "Inability to perform rapid, alternating movements." ; rdfs:label "Lower limb muscle weakness" ; rdfs:subClassOf obo:HP_0003690 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007341 oboInOwl:hasDbXref "UMLS:C1858855" ; oboInOwl:id "HP:0007341" ; a owl:Class ; rdfs:label "Diffuse swelling of cerebral white matter" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001851 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007343 obo:IAO_0000115 "Any structural anomaly of the limbic system, a set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]." ; oboInOwl:hasDbXref "UMLS:C1863392" ; oboInOwl:hasExactSynonym "Limbic malformation" ; oboInOwl:id "HP:0007343" ; a owl:Class ; rdfs:label "Abnormal morphology of the limbic system" ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007344 oboInOwl:hasDbXref "UMLS:C1843858" ; oboInOwl:hasExactSynonym "Atrophic and degenerative changes in the spinal cord" ; oboInOwl:id "HP:0007344" ; a owl:Class ; rdfs:label "Atrophy/Degeneration involving the spinal cord" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007346 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1851430" ; oboInOwl:id "HP:0007346" ; a owl:Class ; rdfs:label "Subcortical white matter calcifications" ; rdfs:subClassOf obo:HP_0002500, obo:HP_0002514 . obo:HP_0007348 oboInOwl:hasDbXref "UMLS:C1850871" ; oboInOwl:id "HP:0007348" ; a owl:Class ; rdfs:label "Hypoplasia of the pyramidal tract" ; rdfs:subClassOf obo:HP_0007363 . obo:HP_0007350 oboInOwl:hasDbXref "UMLS:C1843175" ; oboInOwl:id "HP:0007350" ; a owl:Class ; rdfs:label "Hyperreflexia in upper limbs" ; rdfs:subClassOf obo:HP_0001347, obo:HP_0007054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007351 obo:IAO_0000115 "A type of tremors that is triggered by holding an arm in a fixed position." ; oboInOwl:hasAlternativeId "HP:0007297" ; oboInOwl:hasDbXref "UMLS:C1867138" ; oboInOwl:hasExactSynonym "Postural tremor of arms" ; oboInOwl:id "HP:0007351" ; a owl:Class ; rdfs:label "Upper limb postural tremor" ; rdfs:subClassOf obo:HP_0002174, obo:HP_0200085 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002174 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007352 oboInOwl:hasDbXref "UMLS:C1851431" ; oboInOwl:id "HP:0007352" ; a owl:Class ; rdfs:label "Cerebellar calcifications" ; rdfs:subClassOf obo:HP_0001317, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007354 oboInOwl:hasDbXref "MSH:D000690", "SNOMEDCT_US:86044005", "UMLS:C0002736" ; oboInOwl:hasRelatedSynonym "Lou Gehrig's disease" ; oboInOwl:id "HP:0007354" ; a owl:Class ; rdfs:label "Amyotrophic lateral sclerosis" ; rdfs:subClassOf obo:HP_0007373 . obo:HP_0007359 obo:IAO_0000115 "A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures." ; dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:27:00Z" ; oboInOwl:hasAlternativeId "HP:0002358", "HP:0040168" ; oboInOwl:hasDbXref "MSH:D012640", "SNOMEDCT_US:29753000", "UMLS:C0751495" ; oboInOwl:hasExactSynonym "Focal onset seizure", "Focal seizure", "Focal seizures", "Focal-onset seizures", "Partial seizure", "Partial seizures", "Seizure affecting one half of brain" ; oboInOwl:id "HP:0007359" ; a owl:Class ; rdfs:comment "In 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (>80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination; see Dialeptic seizure." ; rdfs:label "Focal-onset seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0007360 dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:30:00Z" ; oboInOwl:hasAlternativeId "HP:0006857", "HP:0007368" ; oboInOwl:hasDbXref "UMLS:C3279222" ; oboInOwl:hasExactSynonym "Absent/small cerebellum", "Absent/underdeveloped cerebellum", "Atrophy/Degeneration affecting the cerebellum", "Atrophy/Hypoplasia of the cerebellum", "Cerebellar hypoplasia/atrophy" ; oboInOwl:id "HP:0007360" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cerebellum" ; rdfs:subClassOf obo:HP_0001317, obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007361 obo:IAO_0000115 "A structural abnormality of the pons." ; dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:32:00Z" ; oboInOwl:hasDbXref "UMLS:C4024905" ; oboInOwl:hasExactSynonym "Abnormality of the pons" ; oboInOwl:id "HP:0007361" ; a owl:Class ; rdfs:comment "The pons is the portion of the brainstem superior to the medulla oblongata." ; rdfs:label "Abnormal pons morphology" ; rdfs:subClassOf obo:HP_0002363, obo:HP_0011283 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007362 dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4024904" ; oboInOwl:hasExactSynonym "Absent/small brainstem", "Absent/underdeveloped brainstem" ; oboInOwl:id "HP:0007362" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the brainstem" ; rdfs:subClassOf obo:HP_0002363, obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002298 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007363 dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:41:00Z" ; oboInOwl:hasDbXref "UMLS:C4024903" ; oboInOwl:id "HP:0007363" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the pyramidal tract" ; rdfs:subClassOf obo:HP_0002062, obo:HP_0002977 . obo:HP_0007364 dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:43:00Z" ; oboInOwl:hasDbXref "UMLS:C4024902" ; oboInOwl:hasExactSynonym "Absent/small cerebrum", "Absent/underdeveloped cerebrum" ; oboInOwl:id "HP:0007364" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cerebrum" ; rdfs:subClassOf obo:HP_0002060, obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007365 dcterms:creator ; oboInOwl:creation_date "2008-03-31T05:45:00Z" ; oboInOwl:hasDbXref "UMLS:C4024901" ; oboInOwl:id "HP:0007365" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the corticospinal tracts" ; rdfs:subClassOf obo:HP_0002492, obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007366 dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:22:00Z" ; oboInOwl:hasDbXref "UMLS:C4024900" ; oboInOwl:hasExactSynonym "Brainstem atrophy" ; oboInOwl:id "HP:0007366" ; a owl:Class ; rdfs:label "Atrophy/Degeneration affecting the brainstem" ; rdfs:subClassOf obo:HP_0002363, obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002298 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007367 dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:23:00Z" ; oboInOwl:hasDbXref "UMLS:C4024899" ; oboInOwl:hasExactSynonym "Atrophy/Degeneration affecting the CNS" ; oboInOwl:id "HP:0007367" ; a owl:Class ; rdfs:label "Atrophy/Degeneration affecting the central nervous system" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007369 obo:IAO_0000115 "The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:28:00Z" ; oboInOwl:hasDbXref "UMLS:C4024898" ; oboInOwl:id "HP:0007369" ; a owl:Class ; rdfs:label "Atrophy/Degeneration affecting the cerebrum" ; rdfs:subClassOf obo:HP_0002060, obo:HP_0002977, obo:HP_0012444 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007370 obo:IAO_0000115 "Absence or underdevelopment of the corpus callosum." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:35:00Z" ; oboInOwl:hasAlternativeId "HP:0007003", "HP:0007060", "HP:0007061", "HP:0007137" ; oboInOwl:hasDbXref "UMLS:C1861866" ; oboInOwl:hasExactSynonym "Absent/hypoplastic corpus callosum", "Agenesis/hypoplastic corpus callosum", "Complete or partial absence of the corpus callosum", "Hypoplasia or absence of the corpus callosum", "Hypoplastic or absent corpus callosum" ; oboInOwl:id "HP:0007370" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the corpus callosum" ; rdfs:subClassOf obo:HP_0007364, obo:HP_0033725 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007371 obo:IAO_0000115 "The presence of atrophy (wasting) of the corpus callosum." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:36:00Z" ; oboInOwl:hasAlternativeId "HP:0005712" ; oboInOwl:hasDbXref "SNOMEDCT_US:253142006", "UMLS:C0431370" ; oboInOwl:hasExactSynonym "Atrophic corpus callosum", "Atrophy of the corpus callosum", "Atrophy/Degeneration of the corpus callosum" ; oboInOwl:id "HP:0007371" ; a owl:Class ; rdfs:label "Corpus callosum atrophy" ; rdfs:subClassOf obo:HP_0007369, obo:HP_0012762, obo:HP_0033725 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007372 dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:38:00Z" ; oboInOwl:hasDbXref "UMLS:C4024897" ; oboInOwl:id "HP:0007372" ; a owl:Class ; rdfs:label "Atrophy/Degeneration involving the corticospinal tracts" ; rdfs:subClassOf obo:HP_0002492, obo:HP_0007367 . obo:HP_0007373 obo:IAO_0000115 "Wasting involving the motor neuron." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:39:00Z" ; oboInOwl:hasDbXref "UMLS:C4024896" ; oboInOwl:hasExactSynonym "Motor neuron degeneration" ; oboInOwl:id "HP:0007373" ; a owl:Class ; rdfs:label "Motor neuron atrophy" ; rdfs:subClassOf obo:HP_0002450, obo:HP_0007367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007374 dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:47:00Z" ; oboInOwl:hasDbXref "UMLS:C4024895" ; oboInOwl:id "HP:0007374" ; a owl:Class ; rdfs:label "Atrophy/Degeneration involving the caudate nucleus" ; rdfs:subClassOf obo:HP_0002339, obo:HP_0007369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001873 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007375 obo:IAO_0000115 "An abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:48:00Z" ; oboInOwl:hasDbXref "UMLS:C4024894" ; oboInOwl:hasExactSynonym "Abnormality of the septum pellucidum" ; oboInOwl:id "HP:0007375" ; a owl:Class ; rdfs:label "Abnormal septum pellucidum morphology" ; rdfs:subClassOf obo:HP_0002060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007376 obo:IAO_0000115 "An abnormality of the choroid plexus, which is the area in the cerebral ventricles in which cerebrospinal fluid is produced by modified ependymal cells." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T10:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4024893" ; oboInOwl:id "HP:0007376" ; a owl:Class ; rdfs:comment "The choroid plexus is a structure in the ventricles of the brain where cerebrospinal fluid (CSF) is produced." ; rdfs:label "Abnormal choroid plexus morphology" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001886 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007377 obo:IAO_0000115 "An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T11:23:00Z" ; oboInOwl:hasDbXref "UMLS:C4021577" ; oboInOwl:hasExactSynonym "Abnormality of SSEPs" ; oboInOwl:id "HP:0007377" ; a owl:Class ; rdfs:label "Abnormality of somatosensory evoked potentials" ; rdfs:subClassOf obo:HP_0030177, obo:HP_0030178 . obo:HP_0007378 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the gastrointestinal tract." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T11:55:00Z" ; oboInOwl:hasDbXref "MSH:D005770", "NCIT:C3262", "SNOMEDCT_US:126768004", "UMLS:C0017185" ; oboInOwl:hasExactSynonym "GI tract tumor", "GI tract tumour", "Gastrointestinal tract neoplasia", "Gastrointestinal tract neoplasm", "Gastrointestinal tract tumor", "Gastrointestinal tract tumour", "Neoplasm of the GI tract" ; oboInOwl:id "HP:0007378" ; a owl:Class ; rdfs:label "Neoplasm of the gastrointestinal tract" ; rdfs:subClassOf obo:HP_0011024, obo:HP_0034930 . obo:HP_0007379 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the genitourinary system." ; dcterms:creator ; oboInOwl:creation_date "2008-04-01T12:00:00Z" ; oboInOwl:hasDbXref "MSH:D014565", "NCIT:C3262", "UMLS:C0042065", "UMLS:C4020809" ; oboInOwl:hasExactSynonym "Genitourinary tract neoplasm", "Genitourinary tract tumors", "Genitourinary tract tumours", "Neoplasm of the GU tract" ; oboInOwl:hasRelatedSynonym "Genitourinary tract neoplasia" ; oboInOwl:id "HP:0007379" ; a owl:Class ; rdfs:label "Neoplasm of the genitourinary tract" ; rdfs:subClassOf obo:HP_0000119, obo:HP_0011793 . obo:HP_0007380 obo:IAO_0000115 "Telangiectases (small dilated blood vessels) located near the surface of the skin of the face." ; oboInOwl:hasAlternativeId "HP:0007520" ; oboInOwl:hasDbXref "UMLS:C0858684" ; oboInOwl:hasExactSynonym "Facial telangiectatic vessels", "Telangiectasia, facial" ; oboInOwl:id "HP:0007380" ; a owl:Class ; rdfs:label "Facial telangiectasia" ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0007381 oboInOwl:hasDbXref "UMLS:C4024892" ; oboInOwl:id "HP:0007381" ; a owl:Class ; rdfs:label "Congenital exfoliative erythroderma" ; rdfs:subClassOf obo:HP_0001019 . obo:HP_0007383 oboInOwl:hasAlternativeId "HP:0007557" ; oboInOwl:hasDbXref "UMLS:C2673597" ; oboInOwl:hasExactSynonym "Congenital localised absence of skin", "Congenital localised skin absence", "Congenital localized skin absence" ; oboInOwl:id "HP:0007383" ; a owl:Class ; rdfs:label "Congenital localized absence of skin" ; rdfs:subClassOf obo:HP_0008065 . obo:HP_0007384 oboInOwl:hasDbXref "UMLS:C1969516" ; oboInOwl:id "HP:0007384" ; a owl:Class ; rdfs:label "Aberrant melanosome maturation" ; rdfs:subClassOf obo:HP_0011125 . obo:HP_0007385 obo:IAO_0000115 "A developmental defect resulting in the congenital absence of skin on the scalp." ; oboInOwl:hasAlternativeId "HP:0000994", "HP:0007568" ; oboInOwl:hasBroadSynonym "Defect of scalp", "Focal absence of scalp tissue", "Scalp defect", "Solitary scalp defect" ; oboInOwl:hasDbXref "UMLS:C1855698", "UMLS:C4048801", "UMLS:C4072857", "UMLS:C4072858" ; oboInOwl:hasExactSynonym "Scalp aplasia cutis congenita" ; oboInOwl:id "HP:0007385" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplasia cutis congenita of scalp" ; rdfs:subClassOf obo:HP_0001057 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001057 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007387 obo:IAO_0000115 "Underdevelopment of the sweat glands." ; oboInOwl:hasDbXref "UMLS:C1832455" ; oboInOwl:hasExactSynonym "Underdeveloped sweat glands" ; oboInOwl:id "HP:0007387" ; a owl:Class ; rdfs:label "Hypoplastic sweat glands" ; rdfs:subClassOf obo:HP_0011135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007390 oboInOwl:hasDbXref "UMLS:C4024891" ; oboInOwl:id "HP:0007390" ; a owl:Class ; rdfs:label "Hyperkeratosis with erythema" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0007392 oboInOwl:hasDbXref "UMLS:C4024890" ; oboInOwl:hasExactSynonym "Excessive wrinkled skin" ; oboInOwl:id "HP:0007392" ; a owl:Class ; rdfs:label "Excessive wrinkled skin" ; rdfs:subClassOf obo:HP_0008067, obo:HP_0100678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001810 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007394 oboInOwl:hasAlternativeId "HP:0007577" ; oboInOwl:hasDbXref "UMLS:C1848771" ; oboInOwl:hasExactSynonym "Prominent superficial blood vessels", "Prominent superficial vasculature" ; oboInOwl:id "HP:0007394" ; a owl:Class ; rdfs:label "Prominent superficial blood vessels" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0007395 obo:IAO_0000115 "A type of ichthyosiform erythroderma with postnatal onset." ; oboInOwl:hasDbXref "UMLS:C4021576" ; oboInOwl:hasExactSynonym "Postnatal-onset ichthyosis" ; oboInOwl:id "HP:0007395" ; a owl:Class ; rdfs:label "Postnatal-onset ichthyosiform erythroderma" ; rdfs:subClassOf obo:HP_0008064 . obo:HP_0007396 obo:IAO_0000115 "Photosensitivity of the skin occurring early in life." ; oboInOwl:hasDbXref "UMLS:C4024889" ; oboInOwl:hasExactSynonym "Sun sensitivity occurring early in life" ; oboInOwl:id "HP:0007396" ; a owl:Class ; rdfs:label "Early cutaneous photosensitivity" ; rdfs:subClassOf obo:HP_0000992 . obo:HP_0007397 obo:IAO_0000115 "Developmental hypoplasia of the apocrine sweat glands in the region of the axilla." ; oboInOwl:hasDbXref "UMLS:C1867003" ; oboInOwl:id "HP:0007397" ; a owl:Class ; rdfs:label "Axillary apocrine gland hypoplasia" ; rdfs:subClassOf obo:HP_0011135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000382 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007398 oboInOwl:hasDbXref "UMLS:C4024888" ; oboInOwl:id "HP:0007398" ; a owl:Class ; rdfs:label "Asymmetric, linear skin defects" ; rdfs:subClassOf obo:HP_0008065 . obo:HP_0007400 oboInOwl:hasDbXref "UMLS:C1860236" ; oboInOwl:id "HP:0007400" ; a owl:Class ; rdfs:label "Irregular hyperpigmentation" ; rdfs:subClassOf obo:HP_0000953 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000953 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007401 obo:IAO_0000115 "Well-demarcated area(s) of partial or complete depigmentation in the macula, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss." ; oboInOwl:hasDbXref "MSH:D057088", "SNOMEDCT_US:238828009", "UMLS:C1288283" ; oboInOwl:id "HP:0007401" ; a owl:Class ; rdfs:label "Macular atrophy" ; rdfs:subClassOf obo:HP_0000608, obo:HP_0001105 . obo:HP_0007402 oboInOwl:hasDbXref "UMLS:C4024886" ; oboInOwl:id "HP:0007402" ; a owl:Class ; rdfs:label "Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines" ; rdfs:subClassOf obo:HP_0009123 . obo:HP_0007403 oboInOwl:hasDbXref "UMLS:C1867617" ; oboInOwl:hasExactSynonym "Thick skin of soles" ; oboInOwl:id "HP:0007403" ; a owl:Class ; rdfs:label "Hypertrophy of skin of soles" ; rdfs:subClassOf obo:HP_0100872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013778 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007404 obo:IAO_0000115 "Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis." ; oboInOwl:hasDbXref "MSH:C563422", "UMLS:C1833030" ; oboInOwl:hasExactSynonym "Nonepidermolytic palmoplantar keratoderma" ; oboInOwl:id "HP:0007404" ; a owl:Class ; rdfs:label "Nonepidermolytic palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007406 oboInOwl:hasDbXref "MSH:C562400", "SNOMEDCT_US:41115008", "UMLS:C0155211", "UMLS:C0854438", "UMLS:C4280440" ; oboInOwl:hasExactSynonym "Dark eyelids" ; oboInOwl:hasRelatedSynonym "Brown eyelids", "Pigmentation of eyelids" ; oboInOwl:id "HP:0007406" ; a owl:Class ; rdfs:label "Hyperpigmentation of eyelids" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0007400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007407 oboInOwl:hasDbXref "UMLS:C1837467" ; oboInOwl:hasExactSynonym "Excessive skin wrinkling on back of hands and fingers" ; oboInOwl:id "HP:0007407" ; a owl:Class ; rdfs:label "Excessive skin wrinkling on dorsum of hands and fingers" ; rdfs:subClassOf obo:HP_0007392 . obo:HP_0007408 obo:IAO_0000115 "Increased susceptibility to infection by the protozan parasite of the genus Leishmania." ; oboInOwl:hasDbXref "UMLS:C2748501" ; oboInOwl:id "HP:0007408" ; a owl:Class ; rdfs:label "Tegumentary leishmaniasis susceptibility" ; rdfs:subClassOf obo:HP_0005386 . obo:HP_0007409 obo:IAO_0100001 "HP:0003758" ; oboInOwl:id "HP:0007409" ; a owl:Class ; rdfs:label "obsolete Absence of subcutaneous fat over entire body except buttocks, hips, and thighs" ; owl:deprecated true . obo:HP_0007410 obo:IAO_0000115 "An abnormally increased perspiration on palms and soles." ; oboInOwl:hasAlternativeId "HP:0007624" ; oboInOwl:hasDbXref "MSH:C563185", "SNOMEDCT_US:403375001", "UMLS:C1274743" ; oboInOwl:hasExactSynonym "Excessive sweating of palms and soles", "Hyperhidrosis of palms and soles" ; oboInOwl:id "HP:0007410" ; a owl:Class ; rdfs:label "Palmoplantar hyperhidrosis" ; rdfs:subClassOf obo:HP_0006089, obo:HP_0100872 . obo:HP_0007411 oboInOwl:hasDbXref "UMLS:C1844617" ; oboInOwl:id "HP:0007411" ; a owl:Class ; rdfs:label "Hypoplastic-absent sebaceous glands" ; rdfs:subClassOf obo:HP_0008065 . obo:HP_0007412 oboInOwl:hasDbXref "UMLS:C4024885" ; oboInOwl:id "HP:0007412" ; a owl:Class ; rdfs:label "Macular hyperpigmented dermopathy" ; rdfs:subClassOf obo:HP_0001034 . obo:HP_0007413 obo:IAO_0000115 "Naevus flammeus localised in the skin of the forehead." ; oboInOwl:hasDbXref "UMLS:C1848850" ; oboInOwl:hasExactSynonym "Port-wine stain on forehead" ; oboInOwl:id "HP:0007413" ; a owl:Class ; rdfs:label "Nevus flammeus of the forehead" ; rdfs:subClassOf obo:HP_0001052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008200 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007414 oboInOwl:hasDbXref "UMLS:C4024884" ; oboInOwl:hasExactSynonym "Wrinkled skin of hands and feet in newborn" ; oboInOwl:id "HP:0007414" ; a owl:Class ; rdfs:label "Neonatal wrinkled skin of hands and feet" ; rdfs:subClassOf obo:HP_0100678 . obo:HP_0007417 obo:IAO_0000115 "Cutaneous lesion that develops as a dry, scaly, red patch that evolves to an indurated and hyperpigmented plaque with adherent scale. Scarring may result in central white patches (loss of pigmentation) and skin atrophy." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0000981" ; oboInOwl:hasDbXref "MSH:D008179", "SNOMEDCT_US:200938002", "SNOMEDCT_US:238927000", "UMLS:C0024138" ; oboInOwl:hasExactSynonym "Discoid lupus erythematosus" ; oboInOwl:id "HP:0007417" ; a owl:Class ; rdfs:comment "This lesion is characterstic of discoid lupus erythematosus, but similar lesions may be observed in other diseases." ; rdfs:label "Discoid lupus rash" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0007418 obo:IAO_0000115 "Loss of all scalp hair." ; oboInOwl:hasDbXref "SNOMEDCT_US:19754005", "UMLS:C0263504" ; oboInOwl:hasRelatedSynonym "Total alopecia" ; oboInOwl:id "HP:0007418" ; a owl:Class ; rdfs:label "Alopecia totalis" ; rdfs:subClassOf obo:HP_0001596 . obo:HP_0007420 obo:IAO_0000115 "Spontaneous development of hematomas (hematoma) or bruises without significant trauma." ; oboInOwl:hasDbXref "UMLS:C1697453" ; oboInOwl:id "HP:0007420" ; a owl:Class ; rdfs:label "Spontaneous hematomas" ; rdfs:subClassOf obo:HP_0001933 . obo:HP_0007421 obo:IAO_0000115 "Telangiectases (small dilated blood vessels) located near the surface of the skin of the cheeks." ; oboInOwl:hasDbXref "UMLS:C3554587" ; oboInOwl:hasRelatedSynonym "Telangiectasia on the cheeks" ; oboInOwl:id "HP:0007421" ; a owl:Class ; rdfs:label "Telangiectases of the cheeks" ; rdfs:subClassOf obo:HP_0007380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008803 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007425 oboInOwl:hasDbXref "UMLS:C4024883" ; oboInOwl:hasExactSynonym "Hyperelastic face skin", "Stretchable face skin" ; oboInOwl:id "HP:0007425" ; a owl:Class ; rdfs:label "Hyperextensible skin of face" ; rdfs:subClassOf obo:HP_0007458 . obo:HP_0007427 oboInOwl:hasDbXref "UMLS:C3279575", "UMLS:C3279601" ; oboInOwl:hasRelatedSynonym "Reticular pigmentation pattern", "Reticulate skin pigmentation" ; oboInOwl:id "HP:0007427" ; a owl:Class ; rdfs:label "Reticulated skin pigmentation" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007428 obo:IAO_0000115 "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the oral mucosa." ; oboInOwl:hasDbXref "UMLS:C4024882" ; oboInOwl:hasExactSynonym "Angioectasia of the oral mucosa", "Angioectasia of the oral mucous membrane", "Spider veins of the oral mucosa", "Telangiectasia of the oral mucous membrane" ; oboInOwl:id "HP:0007428" ; a owl:Class ; rdfs:label "Telangiectasia of the oral mucosa" ; rdfs:subClassOf obo:HP_0000228 . obo:HP_0007429 obo:IAO_0000115 "The presence of two to five cafe-au-lait macules." ; oboInOwl:hasDbXref "UMLS:C4024881" ; oboInOwl:id "HP:0007429" ; a owl:Class ; rdfs:label "Few cafe-au-lait spots" ; rdfs:subClassOf obo:HP_0000957 . obo:HP_0007430 obo:IAO_0000115 "Generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." ; oboInOwl:hasAlternativeId "HP:0007575" ; oboInOwl:hasDbXref "SNOMEDCT_US:271808008", "UMLS:C1850534" ; oboInOwl:hasExactSynonym "Generalised oedema", "Generalised tissue oedema", "Generalized tissue edema" ; oboInOwl:id "HP:0007430" ; a owl:Class ; rdfs:label "Generalized edema" ; rdfs:subClassOf obo:HP_0000969 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0007431 obo:IAO_0000115 "An ichthyosiform abnormality of the skin with congenital onset." ; oboInOwl:hasAlternativeId "HP:0007478", "HP:0007484" ; oboInOwl:hasDbXref "MSH:D016113", "SNOMEDCT_US:254156001", "SNOMEDCT_US:268282005", "UMLS:C0079583" ; oboInOwl:hasExactSynonym "Congenital ichthyosis", "Ichthyosis, congenital" ; oboInOwl:id "HP:0007431" ; a owl:Class ; rdfs:label "Congenital ichthyosiform erythroderma" ; rdfs:subClassOf obo:HP_0008064 . obo:HP_0007432 oboInOwl:hasDbXref "UMLS:C2749995" ; oboInOwl:hasExactSynonym "Intermittent generalised erythematous papular rash" ; oboInOwl:id "HP:0007432" ; a owl:Class ; rdfs:label "Intermittent generalized erythematous papular rash" ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0007434 obo:IAO_0000115 "Hemangioma is a benign tumor of the vascular endothelial cells. This term refers to facial hemangiomas that have a plaque-like morphology." ; oboInOwl:hasDbXref "UMLS:C1847884" ; oboInOwl:hasExactSynonym "Hemangioma, facial, plaque-like" ; oboInOwl:id "HP:0007434" ; a owl:Class ; rdfs:label "Plaque-like facial hemangioma" ; rdfs:subClassOf obo:HP_0000329 . obo:HP_0007435 obo:IAO_0100001 "HP:0007447" ; oboInOwl:id "HP:0007435" ; a owl:Class ; rdfs:label "obsolete Diffuse palmoplantar keratoderma" ; owl:deprecated true . obo:HP_0007436 oboInOwl:hasDbXref "UMLS:C4024880" ; oboInOwl:id "HP:0007436" ; a owl:Class ; rdfs:label "Hair-nail ectodermal dysplasia" ; rdfs:subClassOf obo:HP_0000968 . obo:HP_0007437 obo:IAO_0000115 "The presence of multiple leiomyomas of the skin." ; oboInOwl:hasDbXref "MSH:C535516", "NCIT:C3157", "UMLS:C1708350" ; oboInOwl:id "HP:0007437" ; a owl:Class ; rdfs:label "Multiple cutaneous leiomyomas" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0007438 oboInOwl:hasDbXref "UMLS:C1851551" ; oboInOwl:id "HP:0007438" ; a owl:Class ; rdfs:label "Mottled pigmentation of the trunk and proximal extremities" ; rdfs:subClassOf obo:HP_0001070 . obo:HP_0007439 oboInOwl:hasDbXref "UMLS:C4024879" ; oboInOwl:hasExactSynonym "Generalised keratosis follicularis" ; oboInOwl:id "HP:0007439" ; a owl:Class ; rdfs:label "Generalized keratosis follicularis" ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0007440 oboInOwl:hasAlternativeId "HP:0007540" ; oboInOwl:hasDbXref "UMLS:C4024878" ; oboInOwl:hasExactSynonym "Generalised hyperpigmentation" ; oboInOwl:id "HP:0007440" ; a owl:Class ; rdfs:label "Generalized hyperpigmentation" ; rdfs:subClassOf obo:HP_0000953 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0007441 oboInOwl:hasDbXref "UMLS:C4024877" ; oboInOwl:id "HP:0007441" ; a owl:Class ; rdfs:label "Hyperpigmented/hypopigmented macules" ; rdfs:subClassOf obo:HP_0009123, obo:HP_0012733 . obo:HP_0007443 obo:IAO_0000115 "Absence of melanin pigment in various areas, which is found at birth and is permanent. The lesions are known as leucoderma and are often found on the face, trunk, or limbs." ; oboInOwl:hasAlternativeId "HP:0001044" ; oboInOwl:hasDbXref "MSH:D016116", "SNOMEDCT_US:6479008", "SNOMEDCT_US:718122005", "UMLS:C0080024" ; oboInOwl:hasExactSynonym "Congenital partial albinism on face, trunk, or limbs", "Congenital partial leucoderma", "Partial absent skin pigmentation" ; oboInOwl:id "HP:0007443" ; a owl:Class ; rdfs:label "Partial albinism" ; rdfs:subClassOf obo:HP_0001010 . obo:HP_0007446 obo:IAO_0000115 "A type of blistering that affects the skin of the palms of the hands and the soles of the feet." ; oboInOwl:hasDbXref "UMLS:C4024876" ; oboInOwl:id "HP:0007446" ; a owl:Class ; rdfs:label "Palmoplantar blistering" ; rdfs:subClassOf obo:HP_0033800, obo:HP_0040211, obo:HP_0100872 . obo:HP_0007447 obo:IAO_0000115 "Diffuse abnormal thickening of the skin on the palms and soles." ; oboInOwl:hasAlternativeId "HP:0007435" ; oboInOwl:hasDbXref "MSH:D015776", "UMLS:C4021575" ; oboInOwl:hasExactSynonym "Diffuse palmoplantar keratoderma", "Hyperkeratosis, diffuse palmoplantar" ; oboInOwl:id "HP:0007447" ; a owl:Class ; rdfs:comment "The terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature." ; rdfs:label "Diffuse palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007448 oboInOwl:hasDbXref "UMLS:C1835253" ; oboInOwl:id "HP:0007448" ; a owl:Class ; rdfs:label "Hyperkeratosis over edematous areas" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0000969 . obo:HP_0007449 oboInOwl:hasDbXref "UMLS:C1851705" ; oboInOwl:id "HP:0007449" ; a owl:Class ; rdfs:label "Confetti-like hypopigmented macules" ; rdfs:subClassOf obo:HP_0020073 . obo:HP_0007450 oboInOwl:hasDbXref "UMLS:C4024875" ; oboInOwl:id "HP:0007450" ; a owl:Class ; rdfs:label "Increased groin pigmentation with raindrop depigmentation" ; rdfs:subClassOf obo:HP_0007400, obo:HP_0009123 . obo:HP_0007451 obo:IAO_0000115 "Inability to sweat on the same side of the face that is affected by ptosis and miosis. This is a feature of Horner syndrome." ; oboInOwl:hasDbXref "UMLS:C4024874" ; oboInOwl:id "HP:0007451" ; a owl:Class ; rdfs:label "Ipsilateral lack of facial sweating" ; rdfs:subClassOf obo:HP_0025276 . obo:HP_0007452 oboInOwl:hasAlternativeId "HP:0007611" ; oboInOwl:hasDbXref "UMLS:C1849377" ; oboInOwl:hasExactSynonym "Midfacial capillary hemangioma" ; oboInOwl:id "HP:0007452" ; a owl:Class ; rdfs:label "Midface capillary hemangioma" ; rdfs:subClassOf obo:HP_0000996 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005306 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007453 obo:IAO_0000115 "Lichenification affecting primarily flexural areas of the skin." ; oboInOwl:hasDbXref "UMLS:C4024873" ; oboInOwl:id "HP:0007453" ; a owl:Class ; rdfs:comment "The parts of the skin that touch when a joint flexes (bends) are called the flexural surfaces." ; rdfs:label "Flexural lichenification" ; rdfs:subClassOf obo:HP_0100725 . obo:HP_0007455 oboInOwl:hasDbXref "MSH:C565010", "UMLS:C1852150" ; oboInOwl:id "HP:0007455" ; a owl:Class ; rdfs:label "Adermatoglyphia" ; rdfs:subClassOf obo:HP_0007477 . obo:HP_0007456 oboInOwl:hasDbXref "UMLS:C4024872" ; oboInOwl:id "HP:0007456" ; a owl:Class ; rdfs:label "Progressive reticulate hyperpigmentation" ; rdfs:subClassOf obo:HP_0007400 . obo:HP_0007457 obo:IAO_0000115 "Prominent thoracic and abdominal veins." ; oboInOwl:hasDbXref "UMLS:C4024871" ; oboInOwl:id "HP:0007457" ; a owl:Class ; rdfs:label "Prominent veins on trunk" ; rdfs:subClassOf obo:HP_0001015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007458 oboInOwl:hasDbXref "UMLS:C4024870" ; oboInOwl:id "HP:0007458" ; a owl:Class ; rdfs:label "Focal hyperextensible skin" ; rdfs:subClassOf obo:HP_0000974 . obo:HP_0007459 oboInOwl:hasDbXref "UMLS:C4024869" ; oboInOwl:hasExactSynonym "Generalised anhidrosis", "Generalised anhydrosis", "Generalised inability to sweat", "Generalized anhydrosis", "Generalized inability to sweat" ; oboInOwl:id "HP:0007459" ; a owl:Class ; rdfs:label "Generalized anhidrosis" ; rdfs:subClassOf obo:HP_0025276 . obo:HP_0007460 obo:IAO_0000115 "The spontaneous detachment of a digit (finger or toe) from the body due to long standing pathology." ; oboInOwl:hasDbXref "UMLS:C1852289" ; oboInOwl:id "HP:0007460" ; a owl:Class ; rdfs:label "Autoamputation of digits" ; rdfs:subClassOf obo:HP_0001218, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001218 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007461 oboInOwl:hasDbXref "SNOMEDCT_US:254785001", "SNOMEDCT_US:47669001", "UMLS:C1384590" ; oboInOwl:id "HP:0007461" ; a owl:Class ; rdfs:label "Hemangiomatosis" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0007462 obo:IAO_0000115 "Keratinization of the bulbar conjunctiva near the limbus (corneoscleral junction), resulting in a raised spot." ; oboInOwl:hasDbXref "SNOMEDCT_US:246871006", "UMLS:C0423178", "UMLS:C4024868" ; oboInOwl:hasRelatedSynonym "Bitot's spots" ; oboInOwl:id "HP:0007462" ; a owl:Class ; rdfs:comment "Bitot spots can be a feature of vitamin A deficiency." ; rdfs:label "Bitot spots of the conjunctiva" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0007464 obo:IAO_0000115 "Reduced number or density of facial hair." ; oboInOwl:hasDbXref "UMLS:C2017869" ; oboInOwl:hasExactSynonym "Sparse facial hair" ; oboInOwl:id "HP:0007464" ; a owl:Class ; rdfs:label "Sparse facial hair" ; rdfs:subClassOf obo:HP_0008070 . obo:HP_0007465 obo:IAO_0000115 "Abnormal thickening of the skin on the palms and soles with an honeycomb pattern." ; oboInOwl:hasDbXref "UMLS:C1866032" ; oboInOwl:id "HP:0007465" ; a owl:Class ; rdfs:label "Honeycomb palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007466 oboInOwl:hasDbXref "UMLS:C1859339" ; oboInOwl:id "HP:0007466" ; a owl:Class ; rdfs:label "Midfrontal capillary hemangioma" ; rdfs:subClassOf obo:HP_0000996 . obo:HP_0007468 obo:IAO_0000115 "Increased amount of keratin (visible as white scales) surrounding hair follicles." ; oboInOwl:hasDbXref "UMLS:C4024867" ; oboInOwl:id "HP:0007468" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Perifollicular hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0031285 . obo:HP_0007469 obo:IAO_0000115 "Cutis gyrata of palms and soles." ; oboInOwl:hasDbXref "UMLS:C1851797" ; oboInOwl:hasExactSynonym "Cutis gyrata of palms and soles" ; oboInOwl:id "HP:0007469" ; a owl:Class ; rdfs:label "Palmoplantar cutis gyrata" ; rdfs:subClassOf obo:HP_0007477, obo:HP_0040211, obo:HP_0100872 . obo:HP_0007470 obo:IAO_0000115 "Subcutaneous nodules that are located in the vicinity of joints." ; oboInOwl:hasDbXref "UMLS:C3806306" ; oboInOwl:id "HP:0007470" ; a owl:Class ; rdfs:label "Periarticular subcutaneous nodules" ; rdfs:subClassOf obo:HP_0001482 . obo:HP_0007471 oboInOwl:hasDbXref "UMLS:C4024866" ; oboInOwl:id "HP:0007471" ; a owl:Class ; rdfs:label "Axillary and groin hyperpigmentation and hypopigmentation" ; rdfs:subClassOf obo:HP_0009123 . obo:HP_0007473 oboInOwl:hasDbXref "UMLS:C1868496" ; oboInOwl:id "HP:0007473" ; a owl:Class ; rdfs:label "Crusting erythematous dermatitis" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0007475 obo:IAO_0000115 "An ichthyosiform abnormality of the skin that presents at birth or shortly thereafter with generalized erythema, blistering, erosions, and peeling. In the subsequent months, erythema and blistering improves but patients go on to develop hyperkeratotic scaling that is especially prominent along the joint flexures, neck, hands and feet." ; oboInOwl:hasDbXref "MSH:D017488", "SNOMEDCT_US:239071005", "SNOMEDCT_US:254167000", "UMLS:C0079153" ; oboInOwl:hasExactSynonym "Bullous congenital ichthyosiform erythroderma", "Epidermolytic hyperkeratosis" ; oboInOwl:id "HP:0007475" ; a owl:Class ; rdfs:comment "Epidermolytic hyperkeratosis can refer to the disease caused by mutations in the genes keratin 1 or keratin 10, but is here used to refer to the characteristic skin manifestations as a phenotypic feature." ; rdfs:label "Congenital bullous ichthyosiform erythroderma" ; rdfs:subClassOf obo:HP_0007431 . obo:HP_0007476 oboInOwl:hasDbXref "MSH:D004476", "SNOMEDCT_US:7731005", "UMLS:C1706004" ; oboInOwl:id "HP:0007476" ; a owl:Class ; rdfs:label "Anhidrotic ectodermal dysplasia" ; rdfs:subClassOf obo:HP_0000968 . obo:HP_0007477 obo:IAO_0000115 "An abnormality of dermatoglyphs (fingerprints), which are present on fingers, palms, toes, and soles." ; oboInOwl:hasAlternativeId "HP:0007422" ; oboInOwl:hasDbXref "SNOMEDCT_US:83145004", "UMLS:C0432333" ; oboInOwl:hasExactSynonym "Abnormal fingerprints", "Dermatoglyphic abnormalities" ; oboInOwl:id "HP:0007477" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal dermatoglyphics" ; rdfs:subClassOf obo:HP_0011356 . obo:HP_0007479 obo:IAO_0000115 "The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales." ; oboInOwl:hasAlternativeId "HP:0001021", "HP:0007388", "HP:0007512", "HP:0007619", "HP:0007625" ; oboInOwl:hasDbXref "MSH:D017490", "SNOMEDCT_US:205550003", "SNOMEDCT_US:267372009", "SNOMEDCT_US:268245001", "UMLS:C0079154" ; oboInOwl:hasExactSynonym "Collodion baby", "Congenital lamellar ichthyosis", "Congenital non-bullous ichthyosis", "Ichthyosis lammellaris", "Ichthyosis, congenital, nonblistering", "Nonbullous congenital ichthyosiform erythroderma", "Nonbullous congenital ichthyosis" ; oboInOwl:id "HP:0007479" ; a owl:Class ; rdfs:label "Congenital nonbullous ichthyosiform erythroderma" ; rdfs:subClassOf obo:HP_0007431 . obo:HP_0007480 oboInOwl:hasDbXref "UMLS:C1868527" ; oboInOwl:id "HP:0007480" ; a owl:Class ; rdfs:label "Decreased sweating due to autonomic dysfunction" ; rdfs:subClassOf obo:HP_0000966 . obo:HP_0007481 oboInOwl:hasDbXref "UMLS:C0746889" ; oboInOwl:id "HP:0007481" ; a owl:Class ; rdfs:label "Hyperpigmented nevi" ; rdfs:subClassOf obo:HP_0000995 . obo:HP_0007482 oboInOwl:hasDbXref "UMLS:C4024865" ; oboInOwl:hasExactSynonym "Generalised papillary lesions" ; oboInOwl:id "HP:0007482" ; a owl:Class ; rdfs:label "Generalized papillary lesions" ; rdfs:subClassOf obo:HP_0011354 . obo:HP_0007483 oboInOwl:hasDbXref "UMLS:C4024864" ; oboInOwl:id "HP:0007483" ; a owl:Class ; rdfs:label "Depigmentation/hyperpigmentation of skin" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007485 obo:IAO_0000115 "Lack of subcutaneous adipose tissue." ; oboInOwl:hasAlternativeId "HP:0007519" ; oboInOwl:hasDbXref "UMLS:C0241267", "UMLS:C4024855" ; oboInOwl:hasExactSynonym "Absent fat below the skin", "General absence of subcutaneous fat", "Lack of fatty tissue below the skin" ; oboInOwl:id "HP:0007485" ; a owl:Class ; rdfs:label "Absence of subcutaneous fat" ; rdfs:subClassOf obo:HP_0008887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002190 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007486 oboInOwl:hasDbXref "NCIT:C3086", "UMLS:C1332863" ; oboInOwl:id "HP:0007486" ; a owl:Class ; rdfs:label "Cavernous hemangioma of the face" ; rdfs:subClassOf obo:HP_0001048 . obo:HP_0007488 oboInOwl:hasDbXref "UMLS:C4024863" ; oboInOwl:id "HP:0007488" ; a owl:Class ; rdfs:label "Diffuse skin atrophy" ; rdfs:subClassOf obo:HP_0004334 . obo:HP_0007489 obo:IAO_0000115 "Telangiectases (small dilated blood vessels) with a diffuse localization." ; oboInOwl:hasAlternativeId "HP:0007405" ; oboInOwl:hasDbXref "SNOMEDCT_US:125279001", "UMLS:C1265776" ; oboInOwl:hasExactSynonym "Diffuse telangiectases", "Telangiectases, random body distribution" ; oboInOwl:id "HP:0007489" ; a owl:Class ; rdfs:label "Diffuse telangiectasia" ; rdfs:subClassOf obo:HP_0001009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001009 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000635 ] ) ] ] . obo:HP_0007490 oboInOwl:hasDbXref "UMLS:C1866031" ; oboInOwl:id "HP:0007490" ; a owl:Class ; rdfs:label "Linear arrays of macular hyperkeratoses in flexural areas" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0007494 oboInOwl:hasDbXref "UMLS:C1851552" ; oboInOwl:id "HP:0007494" ; a owl:Class ; rdfs:label "Discrete 2 to 5-mm hyper- and hypopigmented macules" ; rdfs:subClassOf obo:HP_0007441 . obo:HP_0007495 oboInOwl:hasAlternativeId "HP:0001599" ; oboInOwl:hasDbXref "UMLS:C1857656" ; oboInOwl:hasExactSynonym "Precociously senile appearance", "Prematurely aged appearance" ; oboInOwl:id "HP:0007495" ; a owl:Class ; rdfs:label "Prematurely aged appearance" ; rdfs:subClassOf obo:HP_0011354 . obo:HP_0007497 obo:IAO_0000115 "Hyperkeratosis affecting the palm of the hand and the sole of the foot in areas exposed to friction." ; oboInOwl:hasDbXref "UMLS:C1835654" ; oboInOwl:hasExactSynonym "Hyperkeratosis, palmoplantar, focal friction-related" ; oboInOwl:id "HP:0007497" ; a owl:Class ; rdfs:label "Focal friction-related palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007499 obo:IAO_0000115 "Increased susceptibility to staphylococcal infections, as manifested by recurrent episodes of staphylococcal infections." ; oboInOwl:hasDbXref "UMLS:C4024862" ; oboInOwl:hasExactSynonym "Recurrent staphylococcal infections" ; oboInOwl:id "HP:0007499" ; a owl:Class ; rdfs:label "Recurrent staphylococcal infections" ; rdfs:subClassOf obo:HP_0002718 . obo:HP_0007500 obo:IAO_0000115 "The presence of fewer than normal sweat glands." ; oboInOwl:hasAlternativeId "HP:0007555", "HP:0007594" ; oboInOwl:hasDbXref "UMLS:C4021574" ; oboInOwl:hasExactSynonym "Decreased sweat glands", "Decreased sweat pores" ; oboInOwl:id "HP:0007500" ; a owl:Class ; rdfs:label "Decreased number of sweat glands" ; rdfs:subClassOf obo:HP_0000971 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007501 oboInOwl:hasDbXref "UMLS:C4024861" ; oboInOwl:id "HP:0007501" ; a owl:Class ; rdfs:label "Streaks of hyperkeratosis along each finger onto the palm" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0007502 obo:IAO_0000115 "A skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules resulting from closure of hair follicles with a white plug of sebum." ; oboInOwl:hasAlternativeId "HP:0007600" ; oboInOwl:hasDbXref "SNOMEDCT_US:238629004", "SNOMEDCT_US:402341008", "SNOMEDCT_US:81845009", "UMLS:C0334013" ; oboInOwl:hasExactSynonym "Hyperkeratosis follicularis" ; oboInOwl:id "HP:0007502" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Follicular hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0007503 oboInOwl:hasDbXref "UMLS:C3552528" ; oboInOwl:hasExactSynonym "Generalised ichthyosis" ; oboInOwl:id "HP:0007503" ; a owl:Class ; rdfs:label "Generalized ichthyosis" ; rdfs:subClassOf obo:HP_0008064 . obo:HP_0007504 oboInOwl:hasDbXref "UMLS:C4024860" ; oboInOwl:id "HP:0007504" ; a owl:Class ; rdfs:label "Diffuse slow skin atrophy" ; rdfs:subClassOf obo:HP_0007488 . obo:HP_0007505 oboInOwl:hasDbXref "UMLS:C4024859" ; oboInOwl:id "HP:0007505" ; a owl:Class ; rdfs:label "Progressive hyperpigmentation" ; rdfs:subClassOf obo:HP_0000953 . obo:HP_0007506 oboInOwl:hasDbXref "UMLS:C4024858" ; oboInOwl:hasExactSynonym "Missing skin on limbs since birth" ; oboInOwl:id "HP:0007506" ; a owl:Class ; rdfs:label "Congenital absence of skin of limbs" ; rdfs:subClassOf obo:HP_0007383 . obo:HP_0007508 obo:IAO_0000115 "Tiny bumps of thickened skin (hyperkeratosis) on the palms of the hands." ; oboInOwl:hasDbXref "UMLS:C4024857" ; oboInOwl:id "HP:0007508" ; a owl:Class ; rdfs:label "Punctate palmar hyperkeratosis" ; rdfs:subClassOf obo:HP_0010765 . obo:HP_0007509 oboInOwl:hasAlternativeId "HP:0007487" ; oboInOwl:hasDbXref "UMLS:C4021573" ; oboInOwl:hasExactSynonym "Patchy hypo- and hyper-pigmentation" ; oboInOwl:id "HP:0007509" ; a owl:Class ; rdfs:label "Patchy hypo- and hyperpigmentation" ; rdfs:subClassOf obo:HP_0009123 . obo:HP_0007510 oboInOwl:hasDbXref "UMLS:C1834069" ; oboInOwl:id "HP:0007510" ; a owl:Class ; rdfs:label "Focal dermal aplasia/hypoplasia" ; rdfs:subClassOf obo:HP_0008065 . obo:HP_0007511 oboInOwl:hasDbXref "UMLS:C3151964" ; oboInOwl:id "HP:0007511" ; a owl:Class ; rdfs:label "Mottled pigmentation of photoexposed areas" ; rdfs:subClassOf obo:HP_0001070 . obo:HP_0007513 oboInOwl:hasAlternativeId "HP:0000984", "HP:0007419" ; oboInOwl:hasDbXref "UMLS:C1849923" ; oboInOwl:hasExactSynonym "Fair skin", "Generalised hypopigmentation", "Pale pigmentation" ; oboInOwl:id "HP:0007513" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Generalized hypopigmentation" ; rdfs:subClassOf obo:HP_0001010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0007514 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin on the back of the hands." ; oboInOwl:hasAlternativeId "HP:0007528" ; oboInOwl:hasDbXref "MEDDRA:10058204", "SNOMEDCT_US:443710002", "UMLS:C2732374", "UMLS:C2751873" ; oboInOwl:hasExactSynonym "Edema of dorsum of hands", "Oedema of dorsum of hands", "Oedema of the dorsum of hands" ; oboInOwl:id "HP:0007514" ; a owl:Class ; rdfs:label "Edema of the dorsum of hands" ; rdfs:subClassOf obo:HP_0000969 . obo:HP_0007515 oboInOwl:hasDbXref "UMLS:C1832454" ; oboInOwl:id "HP:0007515" ; a owl:Class ; rdfs:label "Hypoplastic pilosebaceous units" ; rdfs:subClassOf obo:HP_0008065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011932 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007516 obo:IAO_0000115 "Loose and sagging skin of the fingers." ; oboInOwl:hasDbXref "UMLS:C4024856" ; oboInOwl:hasExactSynonym "Extra skin on fingers" ; oboInOwl:id "HP:0007516" ; a owl:Class ; rdfs:label "Redundant skin on fingers" ; rdfs:subClassOf obo:HP_0001582 . obo:HP_0007517 obo:IAO_0000115 "Loose, wrinkled skin of hands and feet." ; oboInOwl:hasAlternativeId "HP:0001016" ; oboInOwl:hasDbXref "UMLS:C1856714" ; oboInOwl:hasExactSynonym "Excessive wrinkled skin of palms and soles", "Furrowed palms and soles", "Increased wrinkles of palms and soles", "Wrinkled palms and soles", "Wrinkled skin of hands and feet" ; oboInOwl:id "HP:0007517" ; a owl:Class ; rdfs:label "Palmoplantar cutis laxa" ; rdfs:subClassOf obo:HP_0000973, obo:HP_0007605, obo:HP_0100872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0007392 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0007605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007519 obo:IAO_0100001 "HP:0007485" ; oboInOwl:id "HP:0007519" ; a owl:Class ; rdfs:label "obsolete Lack of subcutaneous fatty tissue" ; owl:deprecated true . obo:HP_0007521 oboInOwl:hasDbXref "UMLS:C4024854" ; oboInOwl:id "HP:0007521" ; a owl:Class ; rdfs:label "Irregular hyperpigmentation of back" ; rdfs:subClassOf obo:HP_0007400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0007400 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007522 oboInOwl:hasDbXref "UMLS:C4024853" ; oboInOwl:hasExactSynonym "Increased number of skin folds" ; oboInOwl:id "HP:0007522" ; a owl:Class ; rdfs:label "Increased number of skin folds" ; rdfs:subClassOf obo:HP_0008067 . obo:HP_0007524 oboInOwl:hasDbXref "MSH:C537392", "UMLS:C0220695" ; oboInOwl:id "HP:0007524" ; a owl:Class ; rdfs:label "Atypical neurofibromatosis" ; rdfs:subClassOf obo:HP_0001067 . obo:HP_0007525 oboInOwl:hasDbXref "UMLS:C1850533" ; oboInOwl:id "HP:0007525" ; a owl:Class ; rdfs:label "Yellow subcutaneous tissue covered by thin, scaly skin" ; rdfs:subClassOf obo:HP_0001001 . obo:HP_0007526 oboInOwl:hasDbXref "UMLS:C4024852" ; oboInOwl:hasExactSynonym "Hypopigmented upper extremeity skin patches", "Patchy loss of skin color on arms", "Patchy loss of skin colour on arms" ; oboInOwl:id "HP:0007526" ; a owl:Class ; rdfs:label "Hypopigmented skin patches on arms" ; rdfs:subClassOf obo:HP_0001053 . obo:HP_0007529 oboInOwl:hasDbXref "MSH:D004476", "SNOMEDCT_US:54209007", "UMLS:C0162361" ; oboInOwl:id "HP:0007529" ; a owl:Class ; rdfs:label "Hidrotic ectodermal dysplasia" ; rdfs:subClassOf obo:HP_0000968 . obo:HP_0007530 oboInOwl:hasDbXref "UMLS:C4024851" ; oboInOwl:id "HP:0007530" ; a owl:Class ; rdfs:label "Punctate palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007534 obo:IAO_0000115 "Loss of hair in the occipital region of the scalp with congenital onset." ; oboInOwl:hasDbXref "UMLS:C4024850" ; oboInOwl:id "HP:0007534" ; a owl:Class ; rdfs:label "Congenital posterior occipital alopecia" ; rdfs:subClassOf obo:HP_0011361 . obo:HP_0007535 oboInOwl:hasDbXref "UMLS:C1866244" ; oboInOwl:id "HP:0007535" ; a owl:Class ; rdfs:label "Hypopigmented streaks" ; rdfs:subClassOf obo:HP_0001010 . obo:HP_0007536 oboInOwl:hasDbXref "UMLS:C4024849" ; oboInOwl:id "HP:0007536" ; a owl:Class ; rdfs:label "Aplasia cutis congenita of midline scalp vertex" ; rdfs:subClassOf obo:HP_0004471 . obo:HP_0007537 obo:IAO_0000115 "A severe degree of photosensitivity of the skin." ; oboInOwl:hasDbXref "UMLS:C1849186" ; oboInOwl:hasExactSynonym "Severe sun sensitivity" ; oboInOwl:id "HP:0007537" ; a owl:Class ; rdfs:label "Severe photosensitivity" ; rdfs:subClassOf obo:HP_0000992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom _:genid60195 ] . obo:HP_0007541 obo:IAO_0000115 "Presence of a cutaneous lipoma on the forehead." ; oboInOwl:hasDbXref "NCIT:C3192", "UMLS:C1850970" ; oboInOwl:id "HP:0007541" ; a owl:Class ; rdfs:label "Frontal cutaneous lipoma" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0012032 . obo:HP_0007542 obo:IAO_0000115 "Lack of skin pigmentation (coloring) of the anterior chest." ; oboInOwl:hasDbXref "UMLS:C4024848" ; oboInOwl:id "HP:0007542" ; a owl:Class ; rdfs:label "Absent pigmentation of the ventral chest" ; rdfs:subClassOf obo:HP_0040007 ; owl:equivalentClass _:genid60195 . obo:HP_0007543 oboInOwl:hasDbXref "UMLS:C1848773" ; oboInOwl:hasExactSynonym "Increased thickness of skin epidermis" ; oboInOwl:id "HP:0007543" ; a owl:Class ; rdfs:label "Epidermal hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002027 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007544 obo:IAO_0000115 "Piebaldism is characterized by stable and persistent, well-circumscribed depigmented patches present at birth affecting the skin of the face, trunk, and extremities in a symmetrical distribution." ; oboInOwl:hasDbXref "MSH:D016116", "SNOMEDCT_US:6479008", "SNOMEDCT_US:718122005", "UMLS:C0080024" ; oboInOwl:id "HP:0007544" ; a owl:Class ; rdfs:label "Piebaldism" ; rdfs:subClassOf obo:HP_0001010 . obo:HP_0007545 obo:IAO_0000115 "Abnormal thickening of the skin on the palms and soles that is present at birth." ; oboInOwl:hasAlternativeId "HP:0007597" ; oboInOwl:hasDbXref "UMLS:C1855633" ; oboInOwl:hasExactSynonym "Congenital palmoplantar keratoderma", "Congenital palmoplantar keratodermia", "Congenital palmoplantar keratosis" ; oboInOwl:id "HP:0007545" ; a owl:Class ; rdfs:label "Congenital palmoplantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007546 oboInOwl:hasDbXref "UMLS:C3278658" ; oboInOwl:id "HP:0007546" ; a owl:Class ; rdfs:label "Linear hyperpigmentation" ; rdfs:subClassOf obo:HP_0007400 . obo:HP_0007548 obo:IAO_0100001 "HP:0000972" ; oboInOwl:id "HP:0007548" ; a owl:Class ; rdfs:label "obsolete Palmoplantar keratosis with erythema and scale" ; owl:deprecated true . obo:HP_0007549 oboInOwl:hasDbXref "UMLS:C1842714" ; oboInOwl:id "HP:0007549" ; a owl:Class ; rdfs:label "Desquamation of skin soon after birth" ; rdfs:subClassOf obo:HP_0025723 . obo:HP_0007550 oboInOwl:hasDbXref "UMLS:C4021831" ; oboInOwl:hasExactSynonym "Lack of sweating or excessive sweating" ; oboInOwl:id "HP:0007550" ; a owl:Class ; rdfs:label "Hypohidrosis or hyperhidrosis" ; rdfs:subClassOf obo:HP_0025276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0000966 obo:HP_0000975 ) ] ] . obo:HP_0007552 oboInOwl:hasDbXref "UMLS:C1859347" ; oboInOwl:hasExactSynonym "Abnormal fat tissue distribution below the skin" ; oboInOwl:id "HP:0007552" ; a owl:Class ; rdfs:label "Abnormal subcutaneous fat tissue distribution" ; rdfs:subClassOf obo:HP_0001001 . obo:HP_0007553 oboInOwl:hasDbXref "UMLS:C1855459" ; oboInOwl:id "HP:0007553" ; a owl:Class ; rdfs:label "Congenital symmetrical palmoplantar keratosis" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007554 oboInOwl:hasDbXref "UMLS:C4024847" ; oboInOwl:hasExactSynonym "Confetti hypopigmentation pattern of lower leg skin" ; oboInOwl:id "HP:0007554" ; a owl:Class ; rdfs:label "Confetti hypopigmentation pattern of lower leg skin" ; rdfs:subClassOf obo:HP_0001010 . obo:HP_0007556 obo:IAO_0000115 "Hyperkeratosis affecting the sole of the foot." ; oboInOwl:hasAlternativeId "HP:0007382", "HP:0007445" ; oboInOwl:hasDbXref "UMLS:C1856954" ; oboInOwl:hasExactSynonym "Plantar hyperkeratoses" ; oboInOwl:id "HP:0007556" ; a owl:Class ; rdfs:label "Plantar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0100872 . obo:HP_0007559 oboInOwl:hasDbXref "MSH:D053546", "UMLS:C1721006" ; oboInOwl:hasExactSynonym "Localised epidermolytic hyperkeratosis" ; oboInOwl:id "HP:0007559" ; a owl:Class ; rdfs:label "Localized epidermolytic hyperkeratosis" ; rdfs:subClassOf obo:HP_0008064 . obo:HP_0007560 oboInOwl:hasDbXref "UMLS:C4024846" ; oboInOwl:id "HP:0007560" ; a owl:Class ; rdfs:label "Unusual dermatoglyphics" ; rdfs:subClassOf obo:HP_0005882 . obo:HP_0007561 obo:IAO_0100001 "HP:0100585" ; oboInOwl:id "HP:0007561" ; a owl:Class ; rdfs:label "obsolete Telangiectases in sun-exposed and nonexposed skin" ; owl:deprecated true . obo:HP_0007565 obo:IAO_0000115 "The presence of six or more cafe-au-lait spots." ; oboInOwl:hasAlternativeId "HP:0007416" ; oboInOwl:hasBroadSynonym "Multiple birthmarks", "Multiple flat light-brown marks on skin" ; oboInOwl:hasDbXref "MSH:C537421", "UMLS:C1861975" ; oboInOwl:id "HP:0007565" ; a owl:Class ; rdfs:label "Multiple cafe-au-lait spots" ; rdfs:subClassOf obo:HP_0000957 . obo:HP_0007566 oboInOwl:hasDbXref "UMLS:C4024845" ; oboInOwl:id "HP:0007566" ; a owl:Class ; rdfs:label "Index finger dermatoglyphic radial loop" ; rdfs:subClassOf obo:HP_0005882 . obo:HP_0007569 obo:IAO_0000115 "Seborrheic dermatitis that is not localized to any one particular region." ; oboInOwl:hasDbXref "UMLS:C4024844" ; oboInOwl:hasExactSynonym "Generalised seborrheic dermatitis", "Generalised seborrheic eczema", "Generalized seborrheic eczema" ; oboInOwl:id "HP:0007569" ; a owl:Class ; rdfs:label "Generalized seborrheic dermatitis" ; rdfs:subClassOf obo:HP_0001051 . obo:HP_0007570 obo:IAO_0000115 "Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a keratinization abnormality characterized by small, asymptomatic erythematous papules that leave characteristic punctate bleeding when they become detached. The lesions generally occur symmetrically along the top of the foot and on the legs, appearing more rarely on the arms, forearms, palms, and soles, and even on the oral mucosa." ; oboInOwl:hasDbXref "MSH:C538377", "SNOMEDCT_US:28488007", "UMLS:C0263420" ; oboInOwl:hasRelatedSynonym "Flegel disease" ; oboInOwl:id "HP:0007570" ; a owl:Class ; rdfs:label "Hyperkeratosis lenticularis perstans" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0007572 oboInOwl:hasDbXref "UMLS:C1866245" ; oboInOwl:id "HP:0007572" ; a owl:Class ; rdfs:label "Hyperpigmented streaks" ; rdfs:subClassOf obo:HP_0007400 . obo:HP_0007573 obo:IAO_0000115 "A form of atopic dermatitis with onset in adulthood characterized by atopic red face, chronic lichenified eczema on the trunk, subacute or psoriasiform dermatitis." ; oboInOwl:hasDbXref "UMLS:C4024843", "UMLS:C4280439" ; oboInOwl:hasRelatedSynonym "Late onset baby eczema" ; oboInOwl:id "HP:0007573" ; a owl:Class ; rdfs:label "Late onset atopic dermatitis" ; rdfs:subClassOf obo:HP_0001047 . obo:HP_0007574 oboInOwl:hasBroadSynonym "Bronze skin" ; oboInOwl:hasDbXref "UMLS:C2939074", "UMLS:C4024842" ; oboInOwl:hasExactSynonym "Generalised bronze hyperpigmentation" ; oboInOwl:id "HP:0007574" ; a owl:Class ; rdfs:label "Generalized bronze hyperpigmentation" ; rdfs:subClassOf obo:HP_0007440 . obo:HP_0007576 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the palm of the hand." ; oboInOwl:hasDbXref "UMLS:C4024841" ; oboInOwl:hasExactSynonym "Palmar neurofibromas" ; oboInOwl:id "HP:0007576" ; a owl:Class ; rdfs:label "Palmar neurofibroma" ; rdfs:subClassOf obo:HP_0034761, obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001067 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016430 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007581 oboInOwl:hasDbXref "UMLS:C4024840" ; oboInOwl:id "HP:0007581" ; a owl:Class ; rdfs:label "Mediosternal, longitudinal streak of hypopigmentation" ; rdfs:subClassOf obo:HP_0007535 . obo:HP_0007583 oboInOwl:hasDbXref "SNOMEDCT_US:8214000", "UMLS:C0263402" ; oboInOwl:id "HP:0007583" ; a owl:Class ; rdfs:label "Telangiectasia macularis eruptiva perstans" ; rdfs:subClassOf obo:HP_0001009 . obo:HP_0007585 oboInOwl:hasDbXref "UMLS:C1851562" ; oboInOwl:id "HP:0007585" ; a owl:Class ; rdfs:label "Skin fragility with non-scarring blistering" ; rdfs:subClassOf obo:HP_0001030 . obo:HP_0007586 oboInOwl:hasDbXref "UMLS:C4024839" ; oboInOwl:id "HP:0007586" ; a owl:Class ; rdfs:label "Telangiectases producing 'marbled' skin" ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0007587 oboInOwl:hasDbXref "UMLS:C1968565" ; oboInOwl:hasExactSynonym "Numerous pigmented freckles" ; oboInOwl:id "HP:0007587" ; a owl:Class ; rdfs:label "Numerous pigmented freckles" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007588 obo:IAO_0000115 "Increased pigmentation of the skin with a netlike (reticular) pattern." ; oboInOwl:hasAlternativeId "HP:0007579" ; oboInOwl:hasDbXref "UMLS:C1851972" ; oboInOwl:hasExactSynonym "Reticulate hyperpigmentation" ; oboInOwl:id "HP:0007588" ; a owl:Class ; rdfs:label "Reticular hyperpigmentation" ; rdfs:subClassOf obo:HP_0007400 . obo:HP_0007589 obo:IAO_0000115 "A developmental defect resulting in the congenital absence of skin on the trunk or the limbs." ; oboInOwl:hasDbXref "UMLS:C1863496" ; oboInOwl:id "HP:0007589" ; a owl:Class ; rdfs:comment "In future versions of the HPO this term will be made obsolete and will be replaced by terms for Aplasia cutis congenita on trunk and a term for Aplasia cutis congenita on the limbs." ; rdfs:label "Aplasia cutis congenita on trunk or limbs" ; rdfs:subClassOf obo:HP_0001057 . obo:HP_0007590 oboInOwl:hasDbXref "UMLS:C1863495" ; oboInOwl:id "HP:0007590" ; a owl:Class ; rdfs:label "Aplasia cutis congenita over posterior parietal area" ; rdfs:subClassOf obo:HP_0004476 . obo:HP_0007592 obo:IAO_0000115 "Absence or developmental hypoplasia of the eccrine sweat glands." ; oboInOwl:hasDbXref "UMLS:C1844618" ; oboInOwl:hasExactSynonym "Hypoplastic-absent eccrine sweat glands" ; oboInOwl:id "HP:0007592" ; a owl:Class ; rdfs:label "Aplasia/Hypoplastia of the eccrine sweat glands" ; rdfs:subClassOf obo:HP_0011135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007595 oboInOwl:hasDbXref "UMLS:C1835587" ; oboInOwl:hasExactSynonym "Excess skin in infancy" ; oboInOwl:id "HP:0007595" ; a owl:Class ; rdfs:label "Redundant skin in infancy" ; rdfs:subClassOf obo:HP_0001582 . obo:HP_0007596 obo:IAO_0000115 "The presence of multiple subcutaneous lipoma that cause pain." ; oboInOwl:hasDbXref "UMLS:C4024838" ; oboInOwl:hasExactSynonym "Painful noncancerous fat tissue tumor under the skin", "Painful noncancerous fat tissue tumour under the skin" ; oboInOwl:id "HP:0007596" ; a owl:Class ; rdfs:label "Painful subcutaneous lipomas" ; rdfs:subClassOf obo:HP_0001031 . obo:HP_0007597 obo:IAO_0100001 "HP:0007545" ; oboInOwl:id "HP:0007597" ; a owl:Class ; rdfs:label "obsolete Congenital palmoplantar keratodermia" ; owl:deprecated true . obo:HP_0007598 obo:IAO_0000115 "The distal and proximal transverse palmar creases are merged into a single transverse palmar crease on both hands." ; oboInOwl:hasDbXref "UMLS:C1862095" ; oboInOwl:id "HP:0007598" ; a owl:Class ; rdfs:label "Bilateral single transverse palmar creases" ; rdfs:subClassOf obo:HP_0000954 . obo:HP_0007599 oboInOwl:hasDbXref "UMLS:C4024836" ; oboInOwl:hasExactSynonym "Generalised reticulate brown pigmentation" ; oboInOwl:id "HP:0007599" ; a owl:Class ; rdfs:label "Generalized reticulate brown pigmentation" ; rdfs:subClassOf obo:HP_0007440 . obo:HP_0007601 oboInOwl:hasDbXref "UMLS:C1840310" ; oboInOwl:id "HP:0007601" ; a owl:Class ; rdfs:label "Midline facial capillary hemangioma" ; rdfs:subClassOf obo:HP_0000996 . obo:HP_0007602 oboInOwl:hasDbXref "UMLS:C4024835" ; oboInOwl:id "HP:0007602" ; a owl:Class ; rdfs:label "Complex palmar dermatoglyphic pattern" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0007603 oboInOwl:hasDbXref "UMLS:C1859923" ; oboInOwl:hasExactSynonym "Freckles in sun-exposed areas" ; oboInOwl:id "HP:0007603" ; a owl:Class ; rdfs:label "Freckles in sun-exposed areas" ; rdfs:subClassOf obo:HP_0005586 . obo:HP_0007605 oboInOwl:hasAlternativeId "HP:0007531" ; oboInOwl:hasDbXref "UMLS:C4021572" ; oboInOwl:hasExactSynonym "Redundant, wrinkled skin of palms" ; oboInOwl:id "HP:0007605" ; a owl:Class ; rdfs:label "Excessive wrinkling of palmar skin" ; rdfs:subClassOf obo:HP_0007392, obo:HP_0040211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001810 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007606 oboInOwl:hasDbXref "UMLS:C4024834" ; oboInOwl:id "HP:0007606" ; a owl:Class ; rdfs:label "Multiple cutaneous malignancies" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0007607 oboInOwl:hasDbXref "MSH:D053358", "SNOMEDCT_US:239007005", "SNOMEDCT_US:7731005", "UMLS:C0162359" ; oboInOwl:id "HP:0007607" ; a owl:Class ; rdfs:label "Hypohidrotic ectodermal dysplasia" ; rdfs:subClassOf obo:HP_0000968 . obo:HP_0007608 oboInOwl:hasDbXref "UMLS:C4024833" ; oboInOwl:id "HP:0007608" ; a owl:Class ; rdfs:label "Abnormal palmar dermal ridges" ; rdfs:subClassOf obo:HP_0001018 . obo:HP_0007609 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body because of decreased osmotic pressure of plasma (hypoproteinemia)." ; oboInOwl:hasDbXref "UMLS:C4024832" ; oboInOwl:hasExactSynonym "Hypoproteinemic oedema" ; oboInOwl:id "HP:0007609" ; a owl:Class ; rdfs:label "Hypoproteinemic edema" ; rdfs:subClassOf obo:HP_0000969 . obo:HP_0007610 oboInOwl:hasDbXref "UMLS:C4024831" ; oboInOwl:id "HP:0007610" ; a owl:Class ; rdfs:label "Blotching pigmentation of the skin" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007613 oboInOwl:hasDbXref "UMLS:C4024830" ; oboInOwl:id "HP:0007613" ; a owl:Class ; rdfs:label "Spinous keratoses of palms and soles" ; rdfs:subClassOf obo:HP_0000972 . obo:HP_0007616 obo:IAO_0000115 "Naevus flammeus localised in the skin of the neck. This is one of the most common birthmarks and present in approximately 25% of all newborns." ; oboInOwl:hasDbXref "UMLS:C0860468", "UMLS:C4024829", "UMLS:C4280438" ; oboInOwl:hasExactSynonym "Port-wine stain on neck", "Stork bite" ; oboInOwl:hasRelatedSynonym "Angel's kiss", "Salmon patch" ; oboInOwl:id "HP:0007616" ; a owl:Class ; rdfs:comment "The salmon patch is the most common capillary malformation, occurring in up to 50% of all neonates. It is a pinkish macule that typically affects the back of the neck (stork bite) or the glabella (angel's kiss), although it can affect the eyelids, the nose, the upper lip, and the sacral area." ; rdfs:label "Nevus flammeus nuchae" ; rdfs:subClassOf obo:HP_0001052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012477 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007617 oboInOwl:hasDbXref "UMLS:C4024828" ; oboInOwl:id "HP:0007617" ; a owl:Class ; rdfs:label "Fine, reticulate skin pigmentation" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007618 obo:IAO_0000115 "Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument)." ; oboInOwl:hasDbXref "SNOMEDCT_US:17141001", "UMLS:C0263625" ; oboInOwl:hasExactSynonym "Skin calcification" ; oboInOwl:id "HP:0007618" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Subcutaneous calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0011354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011818 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007620 obo:IAO_0000115 "The presence of leiomyoma of the skin." ; oboInOwl:hasAlternativeId "HP:0007507" ; oboInOwl:hasDbXref "NCIT:C3157", "SNOMEDCT_US:254767008", "UMLS:C0346064" ; oboInOwl:hasExactSynonym "Cutaneous leiomyomas", "Cutaneous leiomyomata" ; oboInOwl:id "HP:0007620" ; a owl:Class ; rdfs:comment "Cutaneous leiomyomata are benign soft tissue neoplasms that arise from smooth muscle cells in the skin." ; rdfs:label "Cutaneous leiomyoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0007621 oboInOwl:hasDbXref "UMLS:C4024827" ; oboInOwl:id "HP:0007621" ; a owl:Class ; rdfs:label "Telangiectasia of extensor surfaces" ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0007623 oboInOwl:hasDbXref "UMLS:C4024826" ; oboInOwl:hasExactSynonym "Abnormal pigmentation in sun-exposed skin" ; oboInOwl:id "HP:0007623" ; a owl:Class ; rdfs:label "Pigmentation anomalies of sun-exposed skin" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0007626 obo:IAO_0000115 "Osteomyelitis of the lower jaw." ; oboInOwl:hasAlternativeId "HP:0005869" ; oboInOwl:hasDbXref "SNOMEDCT_US:109695005", "UMLS:C1290708" ; oboInOwl:hasExactSynonym "Lower jaw bone infection", "Osteomyelitis, especially of the mandible" ; oboInOwl:id "HP:0007626" ; a owl:Class ; rdfs:label "Mandibular osteomyelitis" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0002754 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001684 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007627 oboInOwl:hasDbXref "SNOMEDCT_US:235119009", "UMLS:C0399570", "UMLS:C4280429", "UMLS:C4280430", "UMLS:C4280431", "UMLS:C4280432", "UMLS:C4280433", "UMLS:C4280434", "UMLS:C4280435", "UMLS:C4280436", "UMLS:C4280437" ; oboInOwl:hasExactSynonym "Underdevelopment of condylar process of mandible" ; oboInOwl:hasNarrowSynonym "Absence of the condylar head of mandible", "Absence of the condylar neck of mandible", "Absence of the condylar process of mandible", "Failure of development of condylar head of mandible", "Failure of development of condylar neck of mandible", "Failure of development of the condylar process of mandible", "Underdevelopment of condylar head of mandible", "Underdevelopment of condylar neck of mandible" ; oboInOwl:hasRelatedSynonym "Agenesis of condylar head of mandible", "Agenesis of condylar neck of mandible", "Agenesis of condylar process of mandible" ; oboInOwl:id "HP:0007627" ; a owl:Class ; rdfs:label "Mandibular condyle aplasia" ; rdfs:subClassOf obo:HP_0005790 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007628 oboInOwl:hasDbXref "SNOMEDCT_US:235120003", "UMLS:C0399572", "UMLS:C4280423", "UMLS:C4280424", "UMLS:C4280425", "UMLS:C4280426", "UMLS:C4280427", "UMLS:C4280428" ; oboInOwl:hasExactSynonym "Decreased size of condylar process of mandible", "Decreased size of mandibular condyle", "Hypoplasia of condylar process of mandible", "Hypoplasia of mandibular condyle", "Hypoplasia of subcondylar region of mandible", "Small mandibular condyle" ; oboInOwl:hasNarrowSynonym "Hypoplasia of condylar head of mandible", "Hypoplasia of condylar neck of mandible", "Small condylar head of mandible", "Small condylar neck of mandible" ; oboInOwl:hasRelatedSynonym "Hypotrophic condylar process of mandible", "Hypotrophic mandibular condyle" ; oboInOwl:id "HP:0007628" ; a owl:Class ; rdfs:label "Mandibular condyle hypoplasia" ; rdfs:subClassOf obo:HP_0005790 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007633 obo:IAO_0000115 "A developmental anomaly characterized by abnormal smallness of both eyes." ; oboInOwl:hasAlternativeId "HP:0001143", "HP:0001585" ; oboInOwl:hasBroadSynonym "Decreased size of eyeballs", "Decreased size of globes of eyes" ; oboInOwl:hasDbXref "UMLS:C1843496", "UMLS:C4280421", "UMLS:C4280422" ; oboInOwl:hasExactSynonym "Abnormally small eyeball on both sides", "Microphthalmia, bilateral" ; oboInOwl:hasNarrowSynonym "Bilateral nanophthalmos" ; oboInOwl:id "HP:0007633" ; a owl:Class ; rdfs:label "Bilateral microphthalmos" ; rdfs:subClassOf obo:HP_0000568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0007634 obo:IAO_0000115 "An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disc or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates." ; oboInOwl:hasDbXref "UMLS:C1852242" ; oboInOwl:hasExactSynonym "Nonarteritic anterior ischaemic optic neuropathy" ; oboInOwl:id "HP:0007634" ; a owl:Class ; rdfs:comment "Nonarteritic anterior ischemic optic neuropathy is caused by infarction of the laminar or retrolaminar portion of the optic nerve head supplied by the short posterior ciliary arteries. Clinically NAION is characterized by sudden, usually painless, loss of vision in one or both eyes. Examination findings include decreased visual acuity, a visual field defect, decreased colour vision, a relative afferent pupillary defect, and optic disc swelling." ; rdfs:label "Nonarteritic anterior ischemic optic neuropathy" ; rdfs:subClassOf obo:HP_0001138 . obo:HP_0007641 obo:IAO_0000115 "A form of colorblindness in which only two of the three fundamental colors can be distinguished due to a lack of one of the retinal cone pigments." ; oboInOwl:hasDbXref "UMLS:C0858618" ; oboInOwl:hasExactSynonym "Color blindness", "Colour blindness" ; oboInOwl:id "HP:0007641" ; a owl:Class ; rdfs:label "Dyschromatopsia" ; rdfs:subClassOf obo:HP_0000551 . obo:HP_0007642 obo:IAO_0000115 "A nonprogressive (i.e., stationary) form of difficulties with night blindness with congenital onset." ; oboInOwl:hasAlternativeId "HP:0007684", "HP:0007861", "HP:0007953" ; oboInOwl:hasDbXref "MSH:C536122", "MSH:C537743", "SNOMEDCT_US:193687000", "SNOMEDCT_US:232061009", "UMLS:C0339535", "UMLS:C1306122", "UMLS:C3551052", "UMLS:C4048798" ; oboInOwl:hasExactSynonym "Congenital night blindness", "Night blindness since birth", "Static congenital hemeralopia" ; oboInOwl:hasRelatedSynonym "Night blindness, congenital", "Night blindness, congenital stationary", "Night blindness, congenital stationary, complete", "Night blindness, stationary" ; oboInOwl:id "HP:0007642" ; a owl:Class ; rdfs:comment "Congenital stationary night blindness is prinicipally the result of dysfunction of the rod photoreceptors." ; rdfs:label "Congenital stationary night blindness" ; rdfs:subClassOf obo:HP_0000556, obo:HP_0000662 . obo:HP_0007643 obo:IAO_0000115 "Tractional retinal detachment at the periphery of the retina." ; oboInOwl:hasDbXref "UMLS:C4024825" ; oboInOwl:hasExactSynonym "Peripheral traction retinal detachment", "Tractional retinal detachment at the periphery of the retina" ; oboInOwl:id "HP:0007643" ; a owl:Class ; rdfs:label "Peripheral tractional retinal detachment" ; rdfs:subClassOf obo:HP_0007917 . obo:HP_0007646 obo:IAO_0000115 "Lack of eyelashes on the lower lid." ; oboInOwl:hasDbXref "UMLS:C4024824" ; oboInOwl:hasExactSynonym "Absent lower eyelashes", "Atrichia of lower eyelashes", "Failure of development of lower eyelashes" ; oboInOwl:hasNarrowSynonym "Agenesis of lower eyelashes", "Aplasia of lower eyelashes" ; oboInOwl:id "HP:0007646" ; a owl:Class ; rdfs:label "Absent lower eyelashes" ; rdfs:subClassOf obo:HP_0000561 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007647 obo:IAO_0000115 "Congenital abnormality of the extraocular muscles." ; oboInOwl:hasDbXref "UMLS:C4024823" ; oboInOwl:id "HP:0007647" ; a owl:Class ; rdfs:label "Congenital extraocular muscle anomaly" ; rdfs:subClassOf obo:HP_0008049 . obo:HP_0007648 obo:IAO_0000115 "A type of cataract with punctate opacities of the lens." ; oboInOwl:hasDbXref "SNOMEDCT_US:40714009", "UMLS:C0271165", "UMLS:C1969675" ; oboInOwl:hasRelatedSynonym "Punctate lenticular opacities" ; oboInOwl:id "HP:0007648" ; a owl:Class ; rdfs:label "Punctate cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0007649 obo:IAO_0000115 "Sharply demarcated, congenital hyperpigmentation of the retinal pigment epithelium." ; oboInOwl:hasDbXref "SNOMEDCT_US:232074003", "UMLS:C0339555" ; oboInOwl:id "HP:0007649" ; a owl:Class ; rdfs:comment "This feature is found in around 3-5% of the population and is of no functional significance." ; rdfs:label "Congenital hypertrophy of retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0011512 . obo:HP_0007650 oboInOwl:hasDbXref "UMLS:C2062713" ; oboInOwl:id "HP:0007650" ; a owl:Class ; rdfs:label "Progressive ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 . obo:HP_0007651 oboInOwl:hasBroadSynonym "Lower eyelid folded out" ; oboInOwl:hasDbXref "SNOMEDCT_US:95758006", "UMLS:C0521736", "UMLS:C4020808" ; oboInOwl:hasExactSynonym "Lower eyelid turned out" ; oboInOwl:hasRelatedSynonym "Everted lower eyelids" ; oboInOwl:id "HP:0007651" ; a owl:Class ; rdfs:label "Ectropion of lower eyelids" ; rdfs:subClassOf obo:HP_0000656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007654 oboInOwl:id "HP:0007654" ; a owl:Class ; rdfs:label "obsolete Retinal striation" ; owl:deprecated true . obo:HP_0007655 oboInOwl:hasDbXref "UMLS:C1835801" ; oboInOwl:id "HP:0007655" ; a owl:Class ; rdfs:label "Eversion of lateral third of lower eyelids" ; rdfs:subClassOf obo:HP_0000656 . obo:HP_0007656 obo:IAO_0000115 "A congenital defect of development characterized by absence of the lacrimal gland." ; oboInOwl:hasDbXref "UMLS:C4024822" ; oboInOwl:hasExactSynonym "Absent tear gland" ; oboInOwl:id "HP:0007656" ; a owl:Class ; rdfs:label "Lacrimal gland aplasia" ; rdfs:subClassOf obo:HP_0008038 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007657 obo:IAO_0000115 "Opacity of the entire lens nucleus." ; oboInOwl:hasDbXref "UMLS:C4024821" ; oboInOwl:id "HP:0007657" ; a owl:Class ; rdfs:label "Diffuse nuclear cataract" ; rdfs:subClassOf obo:HP_0100018 . obo:HP_0007658 oboInOwl:hasDbXref "UMLS:C4024820" ; oboInOwl:id "HP:0007658" ; a owl:Class ; rdfs:label "Large hyperpigmented retinal spots" ; rdfs:subClassOf obo:HP_0011512 . obo:HP_0007659 oboInOwl:consider "HP:0007703" ; oboInOwl:id "HP:0007659" ; a owl:Class ; rdfs:label "obsolete Decreased retinal pigmentation with dispersion" ; owl:deprecated true . obo:HP_0007661 oboInOwl:hasDbXref "UMLS:C4024819" ; oboInOwl:id "HP:0007661" ; a owl:Class ; rdfs:label "Abnormality of chorioretinal pigmentation" ; rdfs:subClassOf obo:HP_0000532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0007663 oboInOwl:hasAlternativeId "HP:0001091", "HP:0007693", "HP:0007739", "HP:0007969", "HP:0008008" ; oboInOwl:hasDbXref "SNOMEDCT_US:13164000", "UMLS:C0234632" ; oboInOwl:hasExactSynonym "Decreased central vision", "Decreased clarity of vision", "Decreased visual acuity", "Poor visual acuity" ; oboInOwl:id "HP:0007663" ; a owl:Class ; rdfs:label "Reduced visual acuity" ; rdfs:subClassOf obo:HP_0000505 . obo:HP_0007665 obo:IAO_0000115 "Abnormally curly or curved eyelashes." ; oboInOwl:hasDbXref "UMLS:C2673670" ; oboInOwl:hasExactSynonym "Curly eyelashes" ; oboInOwl:id "HP:0007665" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Curly eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000405 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007667 obo:IAO_0000115 "Degenerative changes of the peripheral retina consisting of close-packed tiny cystic spaces at the outer plexiform/inner nuclear retinal level. The degeneration is very common in adult eyes and starts adjacent to the ora serrata and extends circumferentially and posteriorly." ; oboInOwl:hasDbXref "UMLS:C1839362" ; oboInOwl:hasExactSynonym "Cystic retinal degeneration", "Peripheral cystoid degeneration" ; oboInOwl:id "HP:0007667" ; a owl:Class ; rdfs:label "Peripheral cystoid retinal degeneration" ; rdfs:subClassOf obo:HP_0007769 . obo:HP_0007668 oboInOwl:hasDbXref "UMLS:C1969722" ; oboInOwl:id "HP:0007668" ; a owl:Class ; rdfs:label "Impaired pursuit initiation and maintenance" ; rdfs:subClassOf obo:HP_0000617 . obo:HP_0007670 obo:IAO_0000115 "An abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude." ; oboInOwl:hasDbXref "UMLS:C4021571" ; oboInOwl:hasExactSynonym "Abnormal vestibuloocular reflex" ; oboInOwl:id "HP:0007670" ; a owl:Class ; rdfs:label "Abnormal vestibulo-ocular reflex" ; rdfs:subClassOf obo:HP_0001751 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000416 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007675 oboInOwl:hasDbXref "UMLS:C4024818" ; oboInOwl:hasExactSynonym "Progressive night blindness" ; oboInOwl:id "HP:0007675" ; a owl:Class ; rdfs:label "Progressive night blindness" ; rdfs:subClassOf obo:HP_0000662 . obo:HP_0007676 obo:IAO_0000115 "Congenital underdevelopment of the iris." ; oboInOwl:hasAlternativeId "HP:0000638", "HP:0007724", "HP:0007998" ; oboInOwl:hasDbXref "SNOMEDCT_US:95714006", "UMLS:C0344539" ; oboInOwl:hasExactSynonym "Hypoplastic iris", "Iris hypoplasia", "Underdeveloped iris" ; oboInOwl:id "HP:0007676" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the iris" ; rdfs:subClassOf obo:HP_0008053 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007677 obo:IAO_0000115 "Vitelliform maculopathy is a sharply demarcated lesion caused by the accumulation of material, often lipofuscin in the subretinal space underlying the macula." ; oboInOwl:hasAlternativeId "HP:0007878" ; oboInOwl:hasDbXref "MSH:D057826", "SNOMEDCT_US:90036004", "UMLS:C0339510", "UMLS:C4024817" ; oboInOwl:hasExactSynonym "Vitelliform macular lesions" ; oboInOwl:hasRelatedSynonym "Vitelliform macular dystrophy" ; oboInOwl:id "HP:0007677" ; a owl:Class ; rdfs:label "Vitelliform-like macular lesions" ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0007678 obo:IAO_0000115 "Narrowing of a tear duct (lacrimal duct)." ; oboInOwl:hasAlternativeId "HP:0007669" ; oboInOwl:hasDbXref "SNOMEDCT_US:231841004", "UMLS:C0238300" ; oboInOwl:hasExactSynonym "Narrowing of the tear duct", "Nasolacrimal duct stenosis" ; oboInOwl:id "HP:0007678" ; a owl:Class ; rdfs:label "Lacrimal duct stenosis" ; rdfs:subClassOf obo:HP_0000579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002392 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007680 oboInOwl:hasDbXref "UMLS:C4024816" ; oboInOwl:id "HP:0007680" ; a owl:Class ; rdfs:label "Depigmented fundus" ; rdfs:subClassOf obo:HP_0007894 ; owl:equivalentClass _:genid60469 . obo:HP_0007685 oboInOwl:hasDbXref "UMLS:C1851406" ; oboInOwl:id "HP:0007685" ; a owl:Class ; rdfs:label "Peripheral retinal avascularization" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0007686 obo:IAO_0000115 "A functional abnormality of the pupil." ; oboInOwl:hasDbXref "MSH:D011681", "SNOMEDCT_US:72124005", "UMLS:C0917967" ; oboInOwl:id "HP:0007686" ; a owl:Class ; rdfs:comment "It is preferable to describe the functional defect precisely." ; rdfs:label "Abnormal pupillary function" ; rdfs:subClassOf obo:HP_0012373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007687 obo:IAO_0000115 "A unilateral form of ptosis." ; oboInOwl:hasDbXref "UMLS:C1866806" ; oboInOwl:hasExactSynonym "Dropping of one upper eyelid" ; oboInOwl:id "HP:0007687" ; a owl:Class ; rdfs:label "Unilateral ptosis" ; rdfs:subClassOf obo:HP_0000508 . obo:HP_0007688 obo:IAO_0000115 "Absence of the combined rod-and-cone response on electroretinogram." ; oboInOwl:hasAlternativeId "HP:0003230", "HP:0008280" ; oboInOwl:hasDbXref "UMLS:C4021570" ; oboInOwl:hasExactSynonym "Absent cone and rod functions by electroretinogram", "Absent rod-and cone-mediated responses on ERG" ; oboInOwl:id "HP:0007688" ; a owl:Class ; rdfs:label "Undetectable light- and dark-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0008323 . obo:HP_0007690 oboInOwl:hasDbXref "SNOMEDCT_US:32935005", "UMLS:C0271285" ; oboInOwl:id "HP:0007690" ; a owl:Class ; rdfs:label "Map-dot-fingerprint corneal dystrophy" ; rdfs:subClassOf obo:HP_0200020 . obo:HP_0007691 oboInOwl:consider "HP:0007665", "HP:0010764" ; oboInOwl:id "HP:0007691" ; a owl:Class ; rdfs:label "obsolete Short curly eyelashes" ; owl:deprecated true . obo:HP_0007692 obo:IAO_0100001 "HP:0000519" ; oboInOwl:id "HP:0007692" ; a owl:Class ; rdfs:label "obsolete Nonnuclear polymorphic congenital cataract" ; owl:deprecated true . obo:HP_0007695 obo:IAO_0000115 "An abnormality of the reflex that controls the diameter of the pupil, in response to the intensity of light that falls on the retina of the eye." ; oboInOwl:hasDbXref "UMLS:C1970591" ; oboInOwl:id "HP:0007695" ; a owl:Class ; rdfs:label "Abnormal pupillary light reflex" ; rdfs:subClassOf obo:HP_0007686 . obo:HP_0007697 obo:IAO_0000115 "Underdevelopment of the lower eyelid." ; oboInOwl:hasBroadSynonym "Small lower eyelid" ; oboInOwl:hasDbXref "UMLS:C4024814", "UMLS:C4280270", "UMLS:C4280420" ; oboInOwl:hasExactSynonym "Decreased size of lower eyelid", "Underdevelopment of lower eyelid" ; oboInOwl:hasNarrowSynonym "Short lower eyelid" ; oboInOwl:hasRelatedSynonym "Hypotrophic lower eyelid" ; oboInOwl:id "HP:0007697" ; a owl:Class ; rdfs:label "Hypoplasia of the lower eyelids" ; rdfs:subClassOf obo:HP_0430009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007698 oboInOwl:id "HP:0007698" ; a owl:Class ; rdfs:label "obsolete Retinal pigment epithelial atrophy" ; owl:deprecated true . obo:HP_0007700 obo:IAO_0000115 "Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin." ; oboInOwl:hasAlternativeId "HP:0007696", "HP:0007699", "HP:0008040" ; oboInOwl:hasDbXref "SNOMEDCT_US:65075004", "UMLS:C0266525" ; oboInOwl:hasExactSynonym "Anterior chamber cleavage defect", "Anterior chamber cleavage disorder", "Anterior chamber malformation", "Anterior chamber mesodermal anomalies", "Anterior segment developmental abnormality", "Anterior segment dysgenesis", "Anterior segment mesencyhmal dysgenesis", "Anterior segment ocular dysgenesis" ; oboInOwl:id "HP:0007700" ; a owl:Class ; rdfs:comment "In anterior segment mesenchymal ocular dysgenesis (ASMOD), multiple tissues are affected, including the iris, cornea, and lens as well as the Schlemm's canal and trabecular meshwork drainage structures located at the anterior segment angle where the iris and cornea meet. These abnormalities may result from a primary defect in the migration and/or differentiation of the mesenchymal cells that contribute to development of the cornea, iris, and drainage structures." ; rdfs:label "Ocular anterior segment dysgenesis" ; rdfs:subClassOf obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007702 obo:IAO_0100001 "HP:0000580" ; oboInOwl:id "HP:0007702" ; a owl:Class ; rdfs:label "obsolete Pigmentary retinal deposits" ; owl:deprecated true . obo:HP_0007703 oboInOwl:hasAlternativeId "HP:0007741", "HP:0007743", "HP:0008051" ; oboInOwl:hasDbXref "SNOMEDCT_US:421689001", "UMLS:C1720508", "UMLS:C1862475" ; oboInOwl:hasExactSynonym "Abnormal retinal pigmentation", "Abnormality of RPE", "Abnormality of retinal pigment epithelium", "Retinal pigmentary anomaly" ; oboInOwl:hasRelatedSynonym "Abnormality of the retinal pigment epithelium" ; oboInOwl:id "HP:0007703" ; a owl:Class ; rdfs:label "Abnormality of retinal pigmentation" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001782 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007704 obo:IAO_0000115 "Sudden-onset episode of abnormal, involuntary eye movements." ; oboInOwl:hasDbXref "UMLS:C1847515" ; oboInOwl:hasExactSynonym "Abnormal eye movements, paroxysmal" ; oboInOwl:id "HP:0007704" ; a owl:Class ; rdfs:label "Paroxysmal involuntary eye movements" ; rdfs:subClassOf obo:HP_0012547 . obo:HP_0007705 oboInOwl:hasDbXref "SNOMEDCT_US:111521006", "UMLS:C0155118" ; oboInOwl:id "HP:0007705" ; a owl:Class ; rdfs:label "Corneal degeneration" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007707 obo:IAO_0000115 "Absence of the crystalline lens of the eye as a result of a developmental defect." ; oboInOwl:hasDbXref "MSH:C537786", "UMLS:C1853230" ; oboInOwl:hasExactSynonym "Lens agenesis" ; oboInOwl:id "HP:0007707" ; a owl:Class ; rdfs:label "Congenital aphakia" ; rdfs:subClassOf obo:HP_0008063 . obo:HP_0007708 oboInOwl:hasDbXref "UMLS:C4024812" ; oboInOwl:hasExactSynonym "Absent inner eyelashes" ; oboInOwl:id "HP:0007708" ; a owl:Class ; rdfs:label "Absent inner eyelashes" ; rdfs:subClassOf obo:HP_0000561 . obo:HP_0007709 obo:IAO_0000115 "A type of genetically determined disease of the cornea with corneal lesions with a band-like shape." ; oboInOwl:hasDbXref "MSH:C562399", "SNOMEDCT_US:35055000", "UMLS:C0155120" ; oboInOwl:id "HP:0007709" ; a owl:Class ; rdfs:label "Band-shaped corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007710 oboInOwl:hasDbXref "UMLS:C4024811" ; oboInOwl:id "HP:0007710" ; a owl:Class ; rdfs:label "Peripheral vitreous opacities" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0007712 oboInOwl:consider "HP:0001135" ; oboInOwl:id "HP:0007712" ; a owl:Class ; rdfs:label "obsolete Choroidal dystrophy" ; owl:deprecated true . obo:HP_0007713 obo:IAO_0100001 "HP:0010920" ; oboInOwl:id "HP:0007713" ; a owl:Class ; rdfs:label "obsolete Juvenile zonular cataracts" ; owl:deprecated true . obo:HP_0007715 oboInOwl:hasDbXref "UMLS:C1859436" ; oboInOwl:id "HP:0007715" ; a owl:Class ; rdfs:label "Weak extraocular muscles" ; rdfs:subClassOf obo:HP_0000597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007716 obo:IAO_0000115 "A malignant melanoma originating within the eye. The tumor originates from the melanocytes in the uvea (which comprises the iris, ciliary body, and choroid)." ; oboInOwl:hasDbXref "MSH:C536494", "NCIT:C3224", "UMLS:C0220633" ; oboInOwl:hasExactSynonym "Intraocular melanoma" ; oboInOwl:id "HP:0007716" ; a owl:Class ; rdfs:comment "WIth intraocular melanoma, the melanoma originates from melanocytic cells in the uveal layer, comprising the iris, ciliary body, and choroid." ; rdfs:label "Uveal melanoma" ; rdfs:subClassOf obo:HP_0002861, obo:HP_0100012 . obo:HP_0007717 obo:IAO_0000115 "A chronic irritative conjunctivitis, which commonly presents with general irritation and redness of the eyes, with a burning, dry, or foreign-body sensation of the eyes." ; oboInOwl:hasDbXref "UMLS:C4024810" ; oboInOwl:id "HP:0007717" ; a owl:Class ; rdfs:label "Chronic irritative conjunctivitis" ; rdfs:subClassOf obo:HP_0000509 . obo:HP_0007720 obo:IAO_0000115 "Cornea plana is an abnormally flat shape of the cornea such that the normal protrusion of the cornea from the sclera is missing. The reduced corneal curvature can lead to hyperopia, and a hazy corneal limbus and arcus lipoides may develop at an early age." ; oboInOwl:hasDbXref "SNOMEDCT_US:204145006", "UMLS:C0344529" ; oboInOwl:hasExactSynonym "Cornea plana" ; oboInOwl:id "HP:0007720" ; a owl:Class ; rdfs:label "Flat cornea" ; rdfs:subClassOf obo:HP_0100691 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007721 obo:IAO_0000115 "Presence of multiple dilatations (sac-like outpouchings) in the blood vessels of the conjunctiva." ; oboInOwl:hasDbXref "UMLS:C3277464" ; oboInOwl:hasNarrowSynonym "Saccular conjunctival aneurysms" ; oboInOwl:id "HP:0007721" ; a owl:Class ; rdfs:label "Saccular conjunctival dilatations" ; rdfs:subClassOf obo:HP_0008054 . obo:HP_0007722 obo:IAO_0000115 "Atrophy (loss or wasting) of the retinal pigment epithelium observed on fundoscopy or fundus imaging." ; oboInOwl:hasAlternativeId "HP:0007698", "HP:0008017" ; oboInOwl:hasDbXref "UMLS:C1840457" ; oboInOwl:id "HP:0007722" ; a owl:Class ; rdfs:label "Retinal pigment epithelial atrophy" ; rdfs:subClassOf obo:HP_0001105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001782 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007727 obo:IAO_0000115 "Lack of transparency of the corneal epithelium." ; oboInOwl:hasDbXref "UMLS:C1849198" ; oboInOwl:hasExactSynonym "Superficial corneal opacities" ; oboInOwl:id "HP:0007727" ; a owl:Class ; rdfs:label "Opacification of the corneal epithelium" ; rdfs:subClassOf obo:HP_0007957 . obo:HP_0007728 obo:IAO_0000115 "Abnormal (non-physiological) constriction of the pupil of congenital onset." ; oboInOwl:hasDbXref "MSH:C537550", "SNOMEDCT_US:400962005", "UMLS:C1303009" ; oboInOwl:id "HP:0007728" ; a owl:Class ; rdfs:label "Congenital miosis" ; rdfs:subClassOf obo:HP_0000616 . obo:HP_0007730 obo:IAO_0000115 "An abnormal reduction in the amount of pigmentation of the iris." ; oboInOwl:hasDbXref "SNOMEDCT_US:247032003", "SNOMEDCT_US:70397008", "UMLS:C0154920" ; oboInOwl:hasExactSynonym "Light eye color", "Light eye colour", "Reduced iris pigmentation" ; oboInOwl:id "HP:0007730" ; a owl:Class ; rdfs:label "Iris hypopigmentation" ; rdfs:subClassOf obo:HP_0008034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007731 obo:IAO_0000115 "Abnormal development of the choroid and retina." ; oboInOwl:hasDbXref "UMLS:C4024809" ; oboInOwl:id "HP:0007731" ; a owl:Class ; rdfs:label "Chorioretinal dysplasia" ; rdfs:subClassOf obo:HP_0000532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0007732 obo:IAO_0000115 "Underdevelopment of the lacrimal gland." ; oboInOwl:hasDbXref "UMLS:C1863200" ; oboInOwl:hasExactSynonym "Hypoplastic lacrimal gland", "Underdeveloped tear gland" ; oboInOwl:id "HP:0007732" ; a owl:Class ; rdfs:label "Lacrimal gland hypoplasia" ; rdfs:subClassOf obo:HP_0008038 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007733 oboInOwl:hasDbXref "UMLS:C1846266" ; oboInOwl:id "HP:0007733" ; a owl:Class ; rdfs:label "Laterally curved eyebrow" ; rdfs:subClassOf obo:HP_0000534 . obo:HP_0007734 obo:IAO_0000115 "Abnormally big lacrimal glands." ; oboInOwl:hasDbXref "UMLS:C1867030" ; oboInOwl:hasExactSynonym "Enlarged tear gland" ; oboInOwl:id "HP:0007734" ; a owl:Class ; rdfs:label "Enlarged lacrimal glands" ; rdfs:subClassOf obo:HP_0011482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007736 oboInOwl:consider "HP:0000556" ; oboInOwl:id "HP:0007736" ; a owl:Class ; rdfs:label "obsolete Pericentral retinal dystrophy" ; owl:deprecated true . obo:HP_0007737 obo:IAO_0000115 "Pigment migration into the retina in a bone-spicule configuration (resembling the nucleated cells within the lacuna of bone)." ; oboInOwl:hasAlternativeId "HP:0007644", "HP:0007683", "HP:0007823" ; oboInOwl:hasDbXref "UMLS:C1836926" ; oboInOwl:hasExactSynonym "Bone corpuscle fundus pigmentation", "Fundus with peripheral bony spicules", "Retinal bone corpuscle pigmentation", "Retinal pigmented bone spicules" ; oboInOwl:hasRelatedSynonym "Retinal 'bone corpuscle' pigmentation" ; oboInOwl:id "HP:0007737" ; a owl:Class ; rdfs:label "Bone spicule pigmentation of the retina" ; rdfs:subClassOf obo:HP_0000580 . obo:HP_0007738 oboInOwl:hasDbXref "UMLS:C1854686" ; oboInOwl:id "HP:0007738" ; a owl:Class ; rdfs:label "Uncontrolled eye movements" ; rdfs:subClassOf obo:HP_0012547 . obo:HP_0007739 obo:IAO_0100001 "HP:0007663" ; oboInOwl:id "HP:0007739" ; a owl:Class ; rdfs:label "obsolete Mildly reduced visual acuity" ; owl:deprecated true . obo:HP_0007740 oboInOwl:hasDbXref "UMLS:C1850640" ; oboInOwl:hasExactSynonym "Long eyelashes in irregular rows" ; oboInOwl:id "HP:0007740" ; a owl:Class ; rdfs:label "Long eyelashes in irregular rows" ; rdfs:subClassOf obo:HP_0000527 . obo:HP_0007744 oboInOwl:consider "HP:0000612" ; oboInOwl:id "HP:0007744" ; a owl:Class ; rdfs:label "obsolete Iridoretinal coloboma" ; owl:deprecated true . obo:HP_0007747 oboInOwl:hasDbXref "UMLS:C4024807" ; oboInOwl:id "HP:0007747" ; a owl:Class ; rdfs:label "Monocular horizontal nystagmus" ; rdfs:subClassOf obo:HP_0000666 . obo:HP_0007748 oboInOwl:consider "HP:0000612" ; oboInOwl:id "HP:0007748" ; a owl:Class ; rdfs:label "obsolete Irido-fundal coloboma" ; owl:deprecated true . obo:HP_0007750 obo:IAO_0000115 "Underdevelopment of the fovea centralis." ; oboInOwl:hasDbXref "UMLS:C2673946", "UMLS:C4072863" ; oboInOwl:hasExactSynonym "Foveal hypoplasia" ; oboInOwl:id "HP:0007750" ; a owl:Class ; rdfs:comment "A dull foveal reflex is an unusual reflex of the foveal region on fundoscopy that may indicate hypoplasia of the fovea." ; rdfs:label "Hypoplasia of the fovea" ; rdfs:subClassOf obo:HP_0008060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007754 obo:IAO_0000115 "Macular dystrophy is a nonspecific term for premature retinal cell aging and cell death, generally confied to the macula in which no clear extrinsic cause is evident." ; oboInOwl:hasAlternativeId "HP:0007638", "HP:0007798", "HP:0007914", "HP:0007919", "HP:0007999" ; oboInOwl:hasDbXref "UMLS:C0730292" ; oboInOwl:id "HP:0007754" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Macular dystrophy" ; rdfs:subClassOf obo:HP_0000556, obo:HP_0001103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007755 oboInOwl:hasDbXref "MSH:D053559", "SNOMEDCT_US:1674008", "UMLS:C0339277" ; oboInOwl:id "HP:0007755" ; a owl:Class ; rdfs:label "Juvenile epithelial corneal dystrophy" ; rdfs:subClassOf obo:HP_0200020 . obo:HP_0007756 obo:IAO_0100001 "HP:0000594" ; oboInOwl:id "HP:0007756" ; a owl:Class ; rdfs:label "obsolete Slitlike anterior chamber angles in children" ; owl:deprecated true . obo:HP_0007757 obo:IAO_0100001 "HP:0000610" ; oboInOwl:id "HP:0007757" ; a owl:Class ; rdfs:label "obsolete Hypoplasia of choroid" ; owl:deprecated true . obo:HP_0007758 obo:IAO_0100001 "HP:0000505" ; oboInOwl:id "HP:0007758" ; a owl:Class ; rdfs:label "obsolete Congenital visual impairment" ; owl:deprecated true . obo:HP_0007759 obo:IAO_0000115 "Reduced transparency of the stroma of cornea." ; oboInOwl:hasAlternativeId "HP:0000515", "HP:0007662", "HP:0007896", "HP:0007966" ; oboInOwl:hasDbXref "SNOMEDCT_US:246957002", "UMLS:C0423250", "UMLS:C1856661" ; oboInOwl:hasExactSynonym "Cloudy cornea", "Corneal stromal opacity" ; oboInOwl:hasRelatedSynonym "Cloudy corneas" ; oboInOwl:id "HP:0007759" ; a owl:Class ; rdfs:label "Opacification of the corneal stroma" ; rdfs:subClassOf obo:HP_0007957, obo:HP_0011492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000957 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007760 oboInOwl:hasDbXref "MSH:C535475", "SNOMEDCT_US:39662004", "SNOMEDCT_US:419395007", "UMLS:C0271287" ; oboInOwl:id "HP:0007760" ; a owl:Class ; rdfs:label "Crystalline corneal dystrophy" ; rdfs:subClassOf obo:HP_0007856 . obo:HP_0007761 obo:IAO_0000115 "A scotoma (area of diminished vision within the visual field) that surrounds the central fixation point." ; oboInOwl:hasDbXref "SNOMEDCT_US:404650002", "UMLS:C1321308" ; oboInOwl:id "HP:0007761" ; a owl:Class ; rdfs:label "Pericentral scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0007763 obo:IAO_0000115 "Dilatation of small blood vessels of the retina." ; oboInOwl:hasDbXref "SNOMEDCT_US:84884003", "UMLS:C0154835" ; oboInOwl:id "HP:0007763" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal telangiectasia" ; rdfs:subClassOf obo:HP_0001009, obo:HP_0008046 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007765 obo:IAO_0000115 "Increased depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is increased." ; oboInOwl:hasDbXref "SNOMEDCT_US:246991003", "UMLS:C0423280" ; oboInOwl:id "HP:0007765" ; a owl:Class ; rdfs:comment "Deep anterior chamber can be seen in disorders such as congenital microphakia and buphthalmos." ; rdfs:label "Deep anterior chamber" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0007766 obo:IAO_0000115 "Underdevelopment of the optic disc, that is of the optic nerve head, where ganglion cell axons exit the eye to form the optic nerve." ; oboInOwl:hasAlternativeId "HP:0007794", "HP:0007890" ; oboInOwl:hasDbXref "SNOMEDCT_US:373650004", "UMLS:C1298695" ; oboInOwl:hasExactSynonym "Hypoplastic optic discs", "Hypoplastic optic disks" ; oboInOwl:id "HP:0007766" ; a owl:Class ; rdfs:label "Optic disc hypoplasia" ; rdfs:subClassOf obo:HP_0008058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001783 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007768 obo:IAO_0000115 "The presence of an increased number of twists and turns of retinal blood vessels (arteries, arterioles, veins, venules)." ; oboInOwl:hasAlternativeId "HP:0008015" ; oboInOwl:hasDbXref "UMLS:C4021569" ; oboInOwl:hasExactSynonym "Tortuosity of main retinal vessels" ; oboInOwl:id "HP:0007768" ; a owl:Class ; rdfs:label "Central retinal vessel vascular tortuosity" ; rdfs:subClassOf obo:HP_0000631 . obo:HP_0007769 oboInOwl:hasAlternativeId "HP:0007782", "HP:0007805" ; oboInOwl:hasDbXref "SNOMEDCT_US:405721006", "SNOMEDCT_US:61536007", "UMLS:C1320640" ; oboInOwl:id "HP:0007769" ; a owl:Class ; rdfs:label "Peripheral retinal degeneration" ; rdfs:subClassOf obo:HP_0000546 . obo:HP_0007770 oboInOwl:hasDbXref "UMLS:C1854685" ; oboInOwl:hasExactSynonym "Retinal hypoplasia", "Underdeveloped retina" ; oboInOwl:id "HP:0007770" ; a owl:Class ; rdfs:label "Hypoplasia of the retina" ; rdfs:subClassOf obo:HP_0008061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007772 obo:IAO_0000115 "An impairment of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion." ; oboInOwl:hasAlternativeId "HP:0008029" ; oboInOwl:hasDbXref "UMLS:C1837458", "UMLS:C1848530" ; oboInOwl:hasExactSynonym "Abnormality of visual tracking", "Impairment of visual pursuit" ; oboInOwl:hasRelatedSynonym "Abnormal visual pursuit" ; oboInOwl:id "HP:0007772" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Impaired smooth pursuit" ; rdfs:subClassOf obo:HP_0000617 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007773 obo:IAO_0000115 "Ocular abnormality characterised by premature degeneration of the vitreous and the retina that may be associated with increased risk of retinal detachment." ; oboInOwl:hasAlternativeId "HP:0000655" ; oboInOwl:hasDbXref "UMLS:C1850109" ; oboInOwl:hasExactSynonym "Vitreoretinal abnormality", "Vitreoretinal degeneration" ; oboInOwl:id "HP:0007773" ; a owl:Class ; rdfs:label "Vitreoretinopathy" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0007774 obo:IAO_0000115 "Underdevelopment of the ciliary body." ; oboInOwl:hasDbXref "UMLS:C1836890" ; oboInOwl:id "HP:0007774" ; a owl:Class ; rdfs:label "Hypoplasia of the ciliary body" ; rdfs:subClassOf obo:HP_0008055, obo:HP_0012776 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007776 oboInOwl:hasAlternativeId "HP:0007785" ; oboInOwl:hasDbXref "UMLS:C1835148" ; oboInOwl:hasExactSynonym "Hypotrichosis of lower eyelashes", "Partial absence of lower eyelashes", "Scanty lower eyelashes", "Sparse lower eyelashes", "Thin lower eyelashes" ; oboInOwl:id "HP:0007776" ; a owl:Class ; rdfs:label "Sparse lower eyelashes" ; rdfs:subClassOf obo:HP_0000653, obo:HP_0040052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007777 obo:IAO_0000115 "Fibrous connective tissue resulting from incomplete healing of a wound (i.e., a scar) located in the choroid and retina or the eye." ; oboInOwl:hasDbXref "SNOMEDCT_US:53854005", "UMLS:C0008512" ; oboInOwl:id "HP:0007777" ; a owl:Class ; rdfs:label "Chorioretinal scar" ; rdfs:subClassOf obo:HP_0100699, obo:HP_0200065 . obo:HP_0007778 obo:IAO_0000115 "A type of retinal neovascularization that affects the posterior pole of the retina." ; oboInOwl:hasDbXref "UMLS:C4024803" ; oboInOwl:hasExactSynonym "Neovascularization of peripheral and posterior retina", "Posterior retinal neovascularisation" ; oboInOwl:id "HP:0007778" ; a owl:Class ; rdfs:label "Posterior retinal neovascularization" ; rdfs:subClassOf obo:HP_0030666 . obo:HP_0007779 oboInOwl:hasDbXref "UMLS:C1853234" ; oboInOwl:id "HP:0007779" ; a owl:Class ; rdfs:label "Anterior segment of eye aplasia" ; rdfs:subClassOf obo:HP_0008062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007780 obo:IAO_0000115 "A type of cataract characterized by punctate, dust-like opacities within the cortical region of the lens." ; oboInOwl:hasDbXref "UMLS:C4021568" ; oboInOwl:hasExactSynonym "Cataracts, cortical pulverulent" ; oboInOwl:id "HP:0007780" ; a owl:Class ; rdfs:label "Cortical pulverulent cataract" ; rdfs:subClassOf obo:HP_0010693 . obo:HP_0007782 obo:IAO_0100001 "HP:0007769" ; oboInOwl:id "HP:0007782" ; a owl:Class ; rdfs:label "obsolete Peripheral retinal cone degeneration" ; owl:deprecated true . obo:HP_0007783 oboInOwl:consider "HP:0000556" ; oboInOwl:id "HP:0007783" ; a owl:Class ; rdfs:label "obsolete Butterfly retinal pigment epithelial dystrophy" ; owl:deprecated true . obo:HP_0007786 obo:IAO_0100001 "HP:0007858" ; oboInOwl:id "HP:0007786" ; a owl:Class ; rdfs:label "obsolete Lacunar retinal depigmentation" ; owl:deprecated true . obo:HP_0007787 obo:IAO_0000115 "A type of cataract affecting the posterior pole of lens immediately adjacent to ('beneath') the Lens capsule." ; oboInOwl:hasAlternativeId "HP:0007666", "HP:0007857" ; oboInOwl:hasDbXref "SNOMEDCT_US:315353005", "UMLS:C0858617" ; oboInOwl:hasExactSynonym "Posterior subcapsular opacities of the lens" ; oboInOwl:hasRelatedSynonym "Posterior subcapsular cataracts" ; oboInOwl:id "HP:0007787" ; a owl:Class ; rdfs:label "Posterior subcapsular cataract" ; rdfs:subClassOf obo:HP_0000523 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000963 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016459 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007791 obo:IAO_0000115 "Wasting (atrophy) of the retinal pigment epithelium present in small, isolated areas." ; oboInOwl:hasDbXref "UMLS:C4024800" ; oboInOwl:id "HP:0007791" ; a owl:Class ; rdfs:label "Patchy atrophy of the retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0007722 . obo:HP_0007792 oboInOwl:hasDbXref "UMLS:C1843892" ; oboInOwl:id "HP:0007792" ; a owl:Class ; rdfs:label "Microsaccadic pursuit" ; rdfs:subClassOf obo:HP_0001152 . obo:HP_0007793 obo:IAO_0000115 "Mottled (spotted or blotched with different shades) pigmentary abnormality of the macula lutea." ; oboInOwl:hasDbXref "UMLS:C4024799" ; oboInOwl:hasExactSynonym "Macular retinal pigment epithelial mottling" ; oboInOwl:id "HP:0007793" ; a owl:Class ; rdfs:label "Granular macular appearance" ; rdfs:subClassOf obo:HP_0007814, obo:HP_0008002 . obo:HP_0007795 obo:IAO_0000115 "A cataract that affects the anterior part of the cortex of the lens." ; oboInOwl:hasDbXref "UMLS:C1857308" ; oboInOwl:id "HP:0007795" ; a owl:Class ; rdfs:label "Anterior cortical cataract" ; rdfs:subClassOf obo:HP_0100019 . obo:HP_0007797 oboInOwl:hasDbXref "UMLS:C1861791" ; oboInOwl:id "HP:0007797" ; a owl:Class ; rdfs:label "Retinal vascular malformation" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0007798 oboInOwl:consider "HP:0000493" ; oboInOwl:id "HP:0007798" ; a owl:Class ; rdfs:label "obsolete Foveal dystrophy" ; owl:deprecated true . obo:HP_0007799 obo:IAO_0000115 "The presence of whitish deposits in the conjunctiva resembling salt. May be related to calcinosis." ; oboInOwl:hasDbXref "UMLS:C1968901" ; oboInOwl:id "HP:0007799" ; a owl:Class ; rdfs:label "Conjunctival whitish salt-like deposits" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0007800 obo:IAO_0000115 "Abnormal largeness of the eye with an axial length > 2.5 standard deviations from population mean." ; oboInOwl:hasDbXref "UMLS:C1835117" ; oboInOwl:hasExactSynonym "Globe elongated", "Increased axial globe length", "Increased front to back length of eyeball" ; oboInOwl:id "HP:0007800" ; a owl:Class ; rdfs:label "Increased axial length of the globe" ; rdfs:subClassOf obo:HP_0001090 . obo:HP_0007801 oboInOwl:consider "HP:0007703" ; oboInOwl:id "HP:0007801" ; a owl:Class ; rdfs:label "obsolete Fishnet retinal pigmentation" ; owl:deprecated true . obo:HP_0007802 obo:IAO_0000115 "The presence of central, fine, whitish granular lesions in the stroma of the cornea. This type of corneal dystrophy is usually asymptomatic and begins in childhood and shows a slow progression. Later in the course, the corneal epithelium and Bowman's layer may be affected. Histologically, the cornea shows a uniform deposition of hyaline material." ; oboInOwl:hasDbXref "MSH:D003317", "SNOMEDCT_US:45283008", "UMLS:C0018179" ; oboInOwl:id "HP:0007802" ; a owl:Class ; rdfs:label "Granular corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007803 obo:IAO_0000115 "Complete color blindness, a complete inability to distinguish colors. Affected persons cannot perceive colors, but only shades of gray." ; oboInOwl:hasAlternativeId "HP:0007954" ; oboInOwl:hasDbXref "MSH:C536128", "MSH:D003117", "SNOMEDCT_US:56852002", "UMLS:C0152200", "UMLS:C1857618" ; oboInOwl:hasExactSynonym "Complete achromatopsia" ; oboInOwl:hasRelatedSynonym "Total colorblindness" ; oboInOwl:id "HP:0007803" ; a owl:Class ; rdfs:comment "Rod monochromacy is the condition of having only rods in the retina. A rod monochromat is truly unable to see any color and can see only shades of grey." ; rdfs:label "Monochromacy" ; rdfs:subClassOf obo:HP_0000551 . obo:HP_0007807 oboInOwl:hasAlternativeId "HP:0008495" ; oboInOwl:hasDbXref "SNOMEDCT_US:72983001", "UMLS:C0271344" ; oboInOwl:id "HP:0007807" ; a owl:Class ; rdfs:label "Optic nerve compression" ; rdfs:subClassOf obo:HP_0000587, obo:HP_0001293 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007808 obo:IAO_0100001 "HP:0000480" ; oboInOwl:id "HP:0007808" ; a owl:Class ; rdfs:label "obsolete Bilateral retinal coloboma" ; owl:deprecated true . obo:HP_0007809 oboInOwl:hasDbXref "UMLS:C4024796" ; oboInOwl:id "HP:0007809" ; a owl:Class ; rdfs:label "Punctate corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007810 oboInOwl:consider "HP:0000533" ; oboInOwl:id "HP:0007810" ; a owl:Class ; rdfs:label "obsolete Progressive bifocal chorioretinal atrophy" ; owl:deprecated true . obo:HP_0007811 obo:IAO_0000115 "Nystagmus consisting of horizontal to-and-fro eye movements of equal velocity." ; oboInOwl:hasAlternativeId "HP:0200069" ; oboInOwl:hasDbXref "UMLS:C1866180" ; oboInOwl:id "HP:0007811" ; a owl:Class ; rdfs:comment "Pendular nystagmus refers to the situation in which the eye appeared to oscillate with equal speed in either direction, in contrast to jerk nystagmus, in which the movement in one direction is faster than in the other." ; rdfs:label "Horizontal pendular nystagmus" ; rdfs:subClassOf obo:HP_0000666, obo:HP_0006934, obo:HP_0012043 . obo:HP_0007812 obo:IAO_0000115 "The presence of one or more dendritic corneal epithelial ulcers characterized by a treelike branching linear pattern with feathery edges and terminal bulbs. Herpetiform corneal ulcers can be identified by fluorescein staining." ; oboInOwl:hasDbXref "UMLS:C4020911" ; oboInOwl:hasExactSynonym "Dendritic corneal epithelial ulcer", "Herpetiform corneal ulcers" ; oboInOwl:id "HP:0007812" ; a owl:Class ; rdfs:label "Herpetiform corneal ulceration" ; rdfs:subClassOf obo:HP_0012804 . obo:HP_0007813 obo:IAO_0000115 "A form of uveitis that is not associated with the formation of granulomas." ; oboInOwl:hasDbXref "UMLS:C4024795" ; oboInOwl:id "HP:0007813" ; a owl:Class ; rdfs:label "Nongranulomatous uveitis" ; rdfs:subClassOf obo:HP_0000554 . obo:HP_0007814 obo:IAO_0000115 "Mottling (spots or blotches with different shades) of the retinal pigment epithelium, i.e., localized or generalized fundal pigment granularity associated with processes at the level of the retinal pigment epithelium." ; oboInOwl:hasAlternativeId "HP:0001124" ; oboInOwl:hasDbXref "UMLS:C1857644" ; oboInOwl:hasExactSynonym "Focal hypopigmentation of the retinal pigment epithelium", "RPE irregularity", "RPE mottling", "Retinal pigment epithelium irregularity", "Salt and pepper retinal pigmentation", "Salt and pepper retinopathy" ; oboInOwl:id "HP:0007814" ; a owl:Class ; rdfs:label "Retinal pigment epithelial mottling" ; rdfs:subClassOf obo:HP_0007703 . obo:HP_0007815 oboInOwl:hasDbXref "UMLS:C3277463" ; oboInOwl:id "HP:0007815" ; a owl:Class ; rdfs:label "Abnormal distribution of retinal arterioles and venules" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0007817 obo:IAO_0000115 "A supranuclear gaze palsy is an inability to look in a horizontal direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." ; oboInOwl:hasDbXref "UMLS:C4024794" ; oboInOwl:id "HP:0007817" ; a owl:Class ; rdfs:label "Horizontal supranuclear gaze palsy" ; rdfs:subClassOf obo:HP_0000605 . obo:HP_0007818 obo:IAO_0000115 "The presence of distinct colors in the central (pupillary) zone of the iris than in the mid-peripheral (ciliary) zone." ; oboInOwl:hasDbXref "UMLS:C4021567" ; oboInOwl:hasExactSynonym "Ring iris heterochromia" ; oboInOwl:id "HP:0007818" ; a owl:Class ; rdfs:label "Central heterochromia" ; rdfs:subClassOf obo:HP_0001100 . obo:HP_0007819 obo:IAO_0000115 "Presenile cataract is a kind of cataract that occurs in early adulthood, that is, at an age that is younger than usual." ; oboInOwl:hasAlternativeId "HP:0007848" ; oboInOwl:hasDbXref "SNOMEDCT_US:441622000", "UMLS:C0154971" ; oboInOwl:hasExactSynonym "Presenile cataract" ; oboInOwl:id "HP:0007819" ; a owl:Class ; rdfs:comment "Presenile cataract is rare. Some cases have a hereditary cause; others result from trauma or chromosomal, endocrine, metabolic, or systemic disorders. Many cases are idiopathic. The term 'presenile' is used differently in the literature. The HPO defines it to mean a cataract that is diagnosed after the age of 20 years but before old age." ; rdfs:label "Presenile cataracts" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0007820 obo:IAO_0000115 "Congenital absence or closure of the opening of the lacrimal punctum." ; oboInOwl:hasDbXref "UMLS:C1863201" ; oboInOwl:hasExactSynonym "Atretic lacrimal puncta", "Atretic lacrimal punctum" ; oboInOwl:id "HP:0007820" ; a owl:Class ; rdfs:label "Lacrimal punctal atresia" ; rdfs:subClassOf obo:HP_0011479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010284 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007822 oboInOwl:hasDbXref "UMLS:C4024793" ; oboInOwl:id "HP:0007822" ; a owl:Class ; rdfs:label "Central retinal exudate" ; rdfs:subClassOf obo:HP_0001147 . obo:HP_0007824 obo:IAO_0000115 "Paralysis of both the extrinsic and intrinsic ocular muscles." ; oboInOwl:hasDbXref "SNOMEDCT_US:78097002", "UMLS:C0155338" ; oboInOwl:hasExactSynonym "Complete ophthalmoplegia", "Global paralysis of gaze", "Total internal and external ophthalmoplegia" ; oboInOwl:id "HP:0007824" ; a owl:Class ; rdfs:label "Total ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 . obo:HP_0007825 obo:IAO_0100001 "HP:0000518" ; oboInOwl:id "HP:0007825" ; a owl:Class ; rdfs:label "obsolete Cataracts develop in second or third decade" ; owl:deprecated true . obo:HP_0007827 oboInOwl:hasDbXref "UMLS:C4024792" ; oboInOwl:id "HP:0007827" ; a owl:Class ; rdfs:label "Nodular corneal dystrophy" ; rdfs:subClassOf obo:HP_0011494 . obo:HP_0007829 oboInOwl:consider "HP:0000546" ; oboInOwl:id "HP:0007829" ; a owl:Class ; rdfs:label "obsolete Diffuse retinal cone degeneration" ; owl:deprecated true . obo:HP_0007830 obo:IAO_0000115 "Inability to see well at night or in poor light with onset in adulthood." ; oboInOwl:hasDbXref "UMLS:C4024790" ; oboInOwl:hasExactSynonym "Adult-onset night blindness" ; oboInOwl:id "HP:0007830" ; a owl:Class ; rdfs:label "Adult-onset night blindness" ; rdfs:subClassOf obo:HP_0000662 . obo:HP_0007831 obo:IAO_0000115 "Nonprogressive restriction of movement of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited." ; oboInOwl:hasAlternativeId "HP:0007682" ; oboInOwl:hasDbXref "UMLS:C4024789" ; oboInOwl:id "HP:0007831" ; a owl:Class ; rdfs:label "Nonprogressive restrictive external ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000544 . obo:HP_0007832 oboInOwl:hasBroadSynonym "Pigmentation of the outer white part of the eyeball" ; oboInOwl:hasDbXref "UMLS:C1859882" ; oboInOwl:id "HP:0007832" ; a owl:Class ; rdfs:label "Pigmentation of the sclera" ; rdfs:subClassOf obo:HP_0000591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007833 oboInOwl:hasDbXref "UMLS:C4024788" ; oboInOwl:id "HP:0007833" ; a owl:Class ; rdfs:label "Anterior chamber synechiae" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0007834 obo:IAO_0000115 "A kind of cataract that progresses with age." ; oboInOwl:hasAlternativeId "HP:0007828" ; oboInOwl:hasDbXref "UMLS:C4021566" ; oboInOwl:hasExactSynonym "Cataract, progressive" ; oboInOwl:id "HP:0007834" ; a owl:Class ; rdfs:label "Progressive cataract" ; rdfs:subClassOf obo:HP_0000518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000518 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0007835 oboInOwl:hasDbXref "UMLS:C4024787" ; oboInOwl:hasExactSynonym "S-shaped eyes", "S-shaped opening between the eyelids" ; oboInOwl:id "HP:0007835" ; a owl:Class ; rdfs:label "S-shaped palpebral fissures" ; rdfs:subClassOf obo:HP_0200005 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001878 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007836 oboInOwl:hasDbXref "UMLS:C4024786" ; oboInOwl:id "HP:0007836" ; a owl:Class ; rdfs:label "Mosaic corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007838 obo:IAO_0000115 "A progressive form of ptosis." ; oboInOwl:hasDbXref "UMLS:C1834015" ; oboInOwl:hasExactSynonym "Progressive drooping of upper eyelid" ; oboInOwl:id "HP:0007838" ; a owl:Class ; rdfs:label "Progressive ptosis" ; rdfs:subClassOf obo:HP_0000508 . obo:HP_0007840 obo:IAO_0000115 "Increased length of the upper eyelashes." ; oboInOwl:hasDbXref "UMLS:C4024785" ; oboInOwl:hasExactSynonym "Ciliary trichomegaly of upper eyelashes", "Increased length of upper eyelashes", "Long upper eyelashes" ; oboInOwl:id "HP:0007840" ; a owl:Class ; rdfs:label "Long upper eyelashes" ; rdfs:subClassOf obo:HP_0000527, obo:HP_0040051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007841 obo:IAO_0000115 "Deposition of hyaline extracellular material (amyloid) into the vitreous humor, which can manifest as vitreous opacities and reduced visual acuity." ; oboInOwl:hasDbXref "UMLS:C4024784" ; oboInOwl:hasExactSynonym "Amyloid deposition in the vitreous humour", "Vitreous amyloid deposits" ; oboInOwl:id "HP:0007841" ; a owl:Class ; rdfs:label "Amyloid deposition in the vitreous humor" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0007843 oboInOwl:hasDbXref "UMLS:C3278975" ; oboInOwl:hasExactSynonym "Narrowing of blood vessels in back of eye" ; oboInOwl:id "HP:0007843" ; a owl:Class ; rdfs:label "Attenuation of retinal blood vessels" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0007850 oboInOwl:hasDbXref "MSH:D015861", "SNOMEDCT_US:61267008", "UMLS:C0035320" ; oboInOwl:id "HP:0007850" ; a owl:Class ; rdfs:label "Retinal vascular proliferation" ; rdfs:subClassOf obo:HP_0008046 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0008283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007851 oboInOwl:consider "HP:0001103" ; oboInOwl:id "HP:0007851" ; a owl:Class ; rdfs:label "obsolete Temporal displacement of maculae" ; owl:deprecated true . obo:HP_0007852 obo:IAO_0100001 "HP:0000580" ; oboInOwl:id "HP:0007852" ; a owl:Class ; rdfs:label "obsolete Pericentral pigmentary retinopathy" ; owl:deprecated true . obo:HP_0007854 oboInOwl:hasDbXref "SNOMEDCT_US:370961005", "UMLS:C1299694" ; oboInOwl:id "HP:0007854" ; a owl:Class ; rdfs:label "Glaucomatous visual field defect" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0007856 obo:IAO_0000115 "Punctate opacification (reduced transparency) of the corneal stroma." ; oboInOwl:hasAlternativeId "HP:0008004" ; oboInOwl:hasDbXref "UMLS:C4021565" ; oboInOwl:hasExactSynonym "Punctate corneal opacities" ; oboInOwl:id "HP:0007856" ; a owl:Class ; rdfs:label "Punctate opacification of the cornea" ; rdfs:subClassOf obo:HP_0007759 . obo:HP_0007858 obo:IAO_0000115 "Punched out lesions in the pigmented layer of the retina." ; oboInOwl:hasAlternativeId "HP:0007786" ; oboInOwl:hasDbXref "UMLS:C1844751", "UMLS:C4072866" ; oboInOwl:hasRelatedSynonym "Lacunar retinal depigmentation" ; oboInOwl:id "HP:0007858" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A chorioretinal lacuna can have the appearance of a pseudodisk in the retina." ; rdfs:label "Chorioretinal lacunae" ; rdfs:subClassOf obo:HP_0000532 . obo:HP_0007859 obo:IAO_0000115 "Horizontal nystagmus dating from or present at birth." ; oboInOwl:hasDbXref "UMLS:C1866180" ; oboInOwl:hasExactSynonym "Nystagmus, congenital horizontal" ; oboInOwl:id "HP:0007859" ; a owl:Class ; rdfs:label "Congenital horizontal nystagmus" ; rdfs:subClassOf obo:HP_0000666, obo:HP_0006934 . obo:HP_0007862 obo:IAO_0000115 "Deposition of calcium salts in the retina." ; oboInOwl:hasDbXref "UMLS:C1867289" ; oboInOwl:id "HP:0007862" ; a owl:Class ; rdfs:label "Retinal calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0030506 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007866 oboInOwl:hasDbXref "UMLS:C0281967" ; oboInOwl:id "HP:0007866" ; a owl:Class ; rdfs:label "Retinal infarction" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0007867 obo:IAO_0000115 "Fibrosis of only some of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position." ; oboInOwl:hasDbXref "UMLS:C4024781" ; oboInOwl:id "HP:0007867" ; a owl:Class ; rdfs:label "Restrictive partial external ophthalmoplegia" ; rdfs:subClassOf obo:HP_0007936 . obo:HP_0007868 oboInOwl:consider "HP:0000608" ; oboInOwl:id "HP:0007868" ; a owl:Class ; rdfs:label "obsolete Age-related macular degeneration" ; owl:deprecated true . obo:HP_0007869 oboInOwl:id "HP:0007869" ; a owl:Class ; rdfs:label "obsolete Peripheral retinopathy" ; owl:deprecated true . obo:HP_0007872 obo:IAO_0000115 "The presence of multiple hemangiomas in the choroid. These are generally reddish or orange or can have increased pigmentation maiking them difficult to distinguish from choroidal melanomas." ; oboInOwl:hasDbXref "NCIT:C3086", "SNOMEDCT_US:255022003", "UMLS:C0346390" ; oboInOwl:id "HP:0007872" ; a owl:Class ; rdfs:comment "Choroidal hemangiomas can cause hyperopia or other visual symptoms such as blurred or distorted vision. Some choroidal hemangiomas are asymptomatic." ; rdfs:label "Choroidal hemangioma" ; rdfs:subClassOf obo:HP_0001028, obo:HP_0025568 . obo:HP_0007873 oboInOwl:hasAlternativeId "HP:0007940" ; oboInOwl:hasDbXref "UMLS:C1862376" ; oboInOwl:hasExactSynonym "Prominent Schwalbe lines" ; oboInOwl:id "HP:0007873" ; a owl:Class ; rdfs:label "Abnormally prominent line of Schwalbe" ; rdfs:subClassOf obo:HP_0008048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0015007 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011918 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007874 obo:IAO_0000115 "A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point." ; oboInOwl:hasDbXref "UMLS:C4024780" ; oboInOwl:hasExactSynonym "Almond shaped eyes", "Almond-shaped opening between the eyelids" ; oboInOwl:id "HP:0007874" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The almond configuration tends to dissipate with time, as the surrounding tissues (e.g., eyelid, nasal bridge) grow." ; rdfs:label "Almond-shaped palpebral fissure" ; rdfs:subClassOf obo:HP_0200005 . obo:HP_0007875 obo:IAO_0000115 "Blindness with onset at birth." ; oboInOwl:hasAlternativeId "HP:0007706" ; oboInOwl:hasDbXref "SNOMEDCT_US:95486002", "UMLS:C0005754" ; oboInOwl:hasExactSynonym "Blindness present at birth", "Congenital amaurosis" ; oboInOwl:id "HP:0007875" ; a owl:Class ; rdfs:label "Congenital blindness" ; rdfs:subClassOf obo:HP_0000618 . obo:HP_0007876 obo:IAO_0100001 "HP:0100019" ; oboInOwl:id "HP:0007876" ; a owl:Class ; rdfs:label "obsolete Juvenile cortical cataract" ; owl:deprecated true . obo:HP_0007879 obo:IAO_0000115 "Allergic Conjunctivitis is an allergic inflammation of the conjunctiva." ; oboInOwl:hasDbXref "MSH:D003233", "SNOMEDCT_US:231854006", "SNOMEDCT_US:473460002", "UMLS:C0009766" ; oboInOwl:id "HP:0007879" ; a owl:Class ; rdfs:label "Allergic conjunctivitis" ; rdfs:subClassOf obo:HP_0000509, obo:HP_0012393 . obo:HP_0007880 oboInOwl:hasDbXref "UMLS:C4024779" ; oboInOwl:id "HP:0007880" ; a owl:Class ; rdfs:label "Marginal corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007881 oboInOwl:hasDbXref "UMLS:C4024778" ; oboInOwl:id "HP:0007881" ; a owl:Class ; rdfs:label "Central corneal dystrophy" ; rdfs:subClassOf obo:HP_0011493 . obo:HP_0007885 obo:IAO_0000115 "An abnormally slow velocity of horizontal saccadic eye movements." ; oboInOwl:hasDbXref "UMLS:C1856477" ; oboInOwl:id "HP:0007885" ; a owl:Class ; rdfs:comment "Saccades are rapid eye movements that align the fovea with the target." ; rdfs:label "Slowed horizontal saccades" ; rdfs:subClassOf obo:HP_0000514 . obo:HP_0007886 obo:IAO_0000115 "Congenital absence of the extraocular muscles." ; oboInOwl:hasDbXref "UMLS:C1408781", "UMLS:C4024777" ; oboInOwl:hasExactSynonym "Missing eye muscles" ; oboInOwl:hasRelatedSynonym "Absent ocular muscles" ; oboInOwl:id "HP:0007886" ; a owl:Class ; rdfs:label "Absent extraocular muscles" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007889 obo:IAO_0000115 "A type of posterior subcapsular cataract characterized by an iridescent color." ; oboInOwl:hasDbXref "UMLS:C1864573" ; oboInOwl:hasExactSynonym "Cataracts, posterior, subcapsular, iridescent" ; oboInOwl:id "HP:0007889" ; a owl:Class ; rdfs:label "Iridescent posterior subcapsular cataract" ; rdfs:subClassOf obo:HP_0007787 . obo:HP_0007892 obo:IAO_0000115 "Underdevelopment of the lacrimal puncta." ; oboInOwl:hasDbXref "UMLS:C4021564" ; oboInOwl:hasExactSynonym "Hypoplasia of the lacrimal puncta", "Hypoplastic lacrimal puncta" ; oboInOwl:id "HP:0007892" ; a owl:Class ; rdfs:label "Hypoplasia of the lacrimal punctum" ; rdfs:subClassOf obo:HP_0011479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010284 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007893 oboInOwl:id "HP:0007893" ; a owl:Class ; rdfs:label "obsolete Progressive retinal degeneration" ; owl:deprecated true . obo:HP_0007894 obo:IAO_0000115 "Reduced pigmentation of the fundus, typically generalised. Fundoscopy may reveal a low level pigment in both RPE and choroid with clear visibility of choroidal vessels (pale/albinoid) or low pigment level in the RPE with deep pigment in choroid so that visible choroidal vessels are separated by deeply pigmented zones (tesselated/tigroid)." ; oboInOwl:hasAlternativeId "HP:0001111", "HP:0001487", "HP:0007746", "HP:0007752" ; oboInOwl:hasDbXref "SNOMEDCT_US:95694000", "UMLS:C0151891" ; oboInOwl:hasExactSynonym "Decreased fundus pigmentation", "Fundus hypopigmentation" ; oboInOwl:id "HP:0007894" ; a owl:Class ; rdfs:label "Hypopigmentation of the fundus" ; rdfs:subClassOf obo:HP_0031605 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0043473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003951 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007898 oboInOwl:hasDbXref "MSH:D058456", "SNOMEDCT_US:25506007", "SNOMEDCT_US:360455002", "UMLS:C0154832" ; oboInOwl:id "HP:0007898" ; a owl:Class ; rdfs:label "Exudative retinopathy" ; rdfs:subClassOf obo:HP_0001147 . obo:HP_0007899 obo:IAO_0000115 "Failure of attachment of the retina during development." ; oboInOwl:hasAlternativeId "HP:0007849" ; oboInOwl:hasDbXref "UMLS:C4021563" ; oboInOwl:hasExactSynonym "Congenital retinal non-attachment" ; oboInOwl:id "HP:0007899" ; a owl:Class ; rdfs:label "Retinal nonattachment" ; rdfs:subClassOf obo:HP_0000541 . obo:HP_0007900 oboInOwl:hasDbXref "UMLS:C1968574" ; oboInOwl:hasExactSynonym "Underdeveloped tear duct" ; oboInOwl:id "HP:0007900" ; a owl:Class ; rdfs:label "Hypoplastic lacrimal duct" ; rdfs:subClassOf obo:HP_0011481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007901 obo:IAO_0100001 "HP:0000479" ; oboInOwl:id "HP:0007901" ; a owl:Class ; rdfs:label "obsolete Retinal malformation" ; owl:deprecated true . obo:HP_0007902 obo:IAO_0000115 "Bleeding within the vitreous compartment of the eye." ; oboInOwl:hasDbXref "MSH:D014823", "SNOMEDCT_US:31341008", "UMLS:C0042909" ; oboInOwl:hasExactSynonym "Vitreous haemorrhage" ; oboInOwl:id "HP:0007902" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The most common causes include proliferative diabetic retinopathy, vitreous detachment with or without retinal breaks, and trauma. Less common causes include vascular occlusive disease, retinal arterial macroaneurysm, hemoglobinopathies, age-related macular degeneration, intraocular tumors, and others." ; rdfs:label "Vitreous hemorrhage" ; rdfs:subClassOf obo:HP_0004327, obo:HP_0011885 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001797 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007903 obo:IAO_0000115 "Chorioretinal atrophy along the retinal veins." ; oboInOwl:hasDbXref "UMLS:C4072868" ; oboInOwl:id "HP:0007903" ; a owl:Class ; rdfs:label "Paravenous chorioretinal atrophy" ; rdfs:subClassOf obo:HP_0000533 . obo:HP_0007905 oboInOwl:hasDbXref "UMLS:C3275963" ; oboInOwl:hasExactSynonym "Abnormality of iris blood vessels" ; oboInOwl:id "HP:0007905" ; a owl:Class ; rdfs:label "Abnormal iris vasculature" ; rdfs:subClassOf obo:HP_0000525, obo:HP_0008047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007906 obo:IAO_0000115 "Intraocular pressure that is 2 standard deviations above the population mean." ; oboInOwl:hasDbXref "SNOMEDCT_US:112222000", "UMLS:C0234708" ; oboInOwl:hasExactSynonym "Elevated IOP", "Elevated intraocular pressure", "High eye pressure", "Increased IOP", "Increased intraocular pressure", "Raised IOP", "Raised intraocular pressure" ; oboInOwl:id "HP:0007906" ; a owl:Class ; rdfs:label "Ocular hypertension" ; rdfs:subClassOf obo:HP_0012633 . obo:HP_0007910 oboInOwl:consider "HP:0000556" ; oboInOwl:id "HP:0007910" ; a owl:Class ; rdfs:label "obsolete Nonprogressive congenital retinal dystrophy" ; owl:deprecated true . obo:HP_0007911 oboInOwl:hasAlternativeId "HP:0007719", "HP:0007955" ; oboInOwl:hasDbXref "UMLS:C1836264" ; oboInOwl:hasExactSynonym "Congenital drooping of both upper eyelids", "Ptosis, bilateral congenital", "Ptosis, congenital bilateral" ; oboInOwl:id "HP:0007911" ; a owl:Class ; rdfs:label "Congenital bilateral ptosis" ; rdfs:subClassOf obo:HP_0001488, obo:HP_0007970 . obo:HP_0007913 obo:IAO_0000115 "A type of of patterned retinal dystrophy that shows a reticular pattern of pigmentation." ; oboInOwl:hasDbXref "UMLS:C4024776" ; oboInOwl:id "HP:0007913" ; a owl:Class ; rdfs:label "Reticular retinal dystrophy" ; rdfs:subClassOf obo:HP_0007963 . obo:HP_0007915 obo:IAO_0000115 "This corneal dystrophy affects the posterior limiting membrane of the cornea and is characterized by polymorphous plaques of calcium deposits in the deep stromal layers of the cornea, and occasionally by vesicular lesions of the endothelium and edema of the deep corneal stroma." ; oboInOwl:hasDbXref "MSH:C562745", "SNOMEDCT_US:29504002", "UMLS:C0339284" ; oboInOwl:id "HP:0007915" ; a owl:Class ; rdfs:label "Polymorphous posterior corneal dystrophy" ; rdfs:subClassOf obo:HP_0011489, obo:HP_0011491 . obo:HP_0007916 oboInOwl:consider "HP:0007795" ; oboInOwl:id "HP:0007916" ; a owl:Class ; rdfs:label "obsolete Small anterior lens surface opacities" ; owl:deprecated true . obo:HP_0007917 obo:IAO_0000115 "A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes. It is usually seen in the context of diseases that induce a fibrovascular response, e.g. diabetes." ; oboInOwl:hasDbXref "UMLS:C1866178" ; oboInOwl:id "HP:0007917" ; a owl:Class ; rdfs:label "Tractional retinal detachment" ; rdfs:subClassOf obo:HP_0000541 . obo:HP_0007920 obo:IAO_0100001 "HP:0001135" ; oboInOwl:id "HP:0007920" ; a owl:Class ; rdfs:label "obsolete Congenital chorioretinal dystrophy" ; owl:deprecated true . obo:HP_0007922 oboInOwl:hasAlternativeId "HP:0007654" ; oboInOwl:hasDbXref "UMLS:C1849151" ; oboInOwl:hasExactSynonym "Hypermyelinated retinal nerve fibres", "Retinal striation" ; oboInOwl:id "HP:0007922" ; a owl:Class ; rdfs:label "Hypermyelinated retinal nerve fibers" ; rdfs:subClassOf obo:HP_0012447, obo:HP_0020119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042552 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001793 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007923 oboInOwl:consider "HP:0000493" ; oboInOwl:id "HP:0007923" ; a owl:Class ; rdfs:label "obsolete Foveal hyperplasia" ; owl:deprecated true . obo:HP_0007924 oboInOwl:hasAlternativeId "HP:0007652" ; oboInOwl:hasDbXref "UMLS:C1853141", "UMLS:C3278981" ; oboInOwl:hasExactSynonym "Slow decrease in sharpness of vision", "Subacute deterioration of visual acuity" ; oboInOwl:hasRelatedSynonym "Decreased visual acuity, slowly progressive" ; oboInOwl:id "HP:0007924" ; a owl:Class ; rdfs:label "Slow decrease in visual acuity" ; rdfs:subClassOf obo:HP_0000529 . obo:HP_0007925 obo:IAO_0000115 "A congenital defect resulting in absence of the lacrimal duct." ; oboInOwl:hasDbXref "UMLS:C4024773" ; oboInOwl:hasExactSynonym "Absent tear duct" ; oboInOwl:id "HP:0007925" ; a owl:Class ; rdfs:label "Lacrimal duct aplasia" ; rdfs:subClassOf obo:HP_0011481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007928 obo:IAO_0000115 "Anomaly of the visual evoked potentials elicited by a flash stimulus, generally a flash of light subtending an angle of at least 20 degrees of the visual field and presented in a dimly lit room." ; oboInOwl:hasDbXref "UMLS:C4024772" ; oboInOwl:id "HP:0007928" ; a owl:Class ; rdfs:label "Abnormal flash visual evoked potentials" ; rdfs:subClassOf obo:HP_0000649 . obo:HP_0007929 obo:IAO_0000115 "Separation of the inner layers of the retina (neural retina) from the pigment epithelium occuring near the outer limit (periphery) of the retina." ; oboInOwl:hasDbXref "UMLS:C4024771" ; oboInOwl:id "HP:0007929" ; a owl:Class ; rdfs:label "Peripheral retinal detachment" ; rdfs:subClassOf obo:HP_0000541 . obo:HP_0007930 obo:IAO_0100001 "HP:0000286" ; oboInOwl:id "HP:0007930" ; a owl:Class ; rdfs:label "obsolete Prominent epicanthal folds" ; owl:deprecated true . obo:HP_0007932 obo:IAO_0000115 "Congenital abnormal dilation of the pupil on both sides." ; oboInOwl:hasDbXref "UMLS:C4024770" ; oboInOwl:id "HP:0007932" ; a owl:Class ; rdfs:label "Bilateral congenital mydriasis" ; rdfs:subClassOf obo:HP_0011499 . obo:HP_0007933 obo:IAO_0000115 "Regional increase in the width (height) of the lateral eyebrow." ; oboInOwl:hasDbXref "UMLS:C1837733" ; oboInOwl:hasExactSynonym "Lateral eyebrow flare", "Wide lateral eyebrow" ; oboInOwl:id "HP:0007933" ; a owl:Class ; rdfs:label "Broad lateral eyebrow" ; rdfs:subClassOf obo:HP_0011229 . obo:HP_0007935 oboInOwl:hasDbXref "UMLS:C1863408" ; oboInOwl:id "HP:0007935" ; a owl:Class ; rdfs:label "Juvenile posterior subcapsular lenticular opacities" ; rdfs:subClassOf obo:HP_0007787 . obo:HP_0007936 obo:IAO_0000115 "Fibrosis of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited." ; oboInOwl:hasAlternativeId "HP:0007846", "HP:0007959", "HP:0008025" ; oboInOwl:hasDbXref "UMLS:C1865918", "UMLS:C4020806" ; oboInOwl:hasExactSynonym "Restrictive ophthalmoplegia" ; oboInOwl:hasRelatedSynonym "Restrictive external ophthalmoplegia, bilateral" ; oboInOwl:id "HP:0007936" ; a owl:Class ; rdfs:label "Restrictive external ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000544 . obo:HP_0007937 obo:IAO_0000115 "A type of retinal reticular pigmentation that forms a polygonal, netlike arrangement of hyperpigmented lines forming geometric patterns in the fundus." ; oboInOwl:hasDbXref "UMLS:C4024769" ; oboInOwl:hasExactSynonym "Fishnet retinal pigmentation", "Honeycomb retinal degeneration" ; oboInOwl:id "HP:0007937" ; a owl:Class ; rdfs:label "Reticular pigmentary degeneration" ; rdfs:subClassOf obo:HP_0007769, obo:HP_0011512 . obo:HP_0007939 obo:IAO_0000115 "A form of monochromacy in which vision is derived from the remaining preserved blue (S) cones and rod photoreceptors." ; oboInOwl:hasDbXref "MSH:C536238", "SNOMEDCT_US:24704003", "UMLS:C0339537" ; oboInOwl:hasExactSynonym "Blue cone monochromatism", "Incomplete achromatopsia", "S-cone monochromacy" ; oboInOwl:id "HP:0007939" ; a owl:Class ; rdfs:label "Blue cone monochromacy" ; rdfs:subClassOf obo:HP_0011517 . obo:HP_0007941 obo:IAO_0000115 "Limited mobility of the eye within its socket." ; oboInOwl:hasDbXref "UMLS:C1858427" ; oboInOwl:hasExactSynonym "Limited extraocular movement" ; oboInOwl:id "HP:0007941" ; a owl:Class ; rdfs:label "Limited extraocular movements" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0007942 obo:IAO_0000115 "Paralysis of the iris and ciliary apparatus." ; oboInOwl:hasDbXref "MSH:D009886", "SNOMEDCT_US:232146005", "UMLS:C0339693" ; oboInOwl:id "HP:0007942" ; a owl:Class ; rdfs:comment "Paralysis of the internal ocular muscles, the iris and ciliary apparatus." ; rdfs:label "Internal ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000602 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007943 obo:IAO_0000115 "A form of stapes ankylosis with congenital onset." ; oboInOwl:hasDbXref "UMLS:C1866657" ; oboInOwl:id "HP:0007943" ; a owl:Class ; rdfs:label "Congenital stapes ankylosis" ; rdfs:subClassOf obo:HP_0000381 . obo:HP_0007944 oboInOwl:hasDbXref "UMLS:C4024768" ; oboInOwl:id "HP:0007944" ; a owl:Class ; rdfs:label "Intermittent microsaccadic pursuits" ; rdfs:subClassOf obo:HP_0001152 . obo:HP_0007945 oboInOwl:consider "HP:0200065" ; oboInOwl:id "HP:0007945" ; a owl:Class ; rdfs:label "obsolete Choroidal degeneration" ; owl:deprecated true . obo:HP_0007946 obo:IAO_0000115 "A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures on one side only." ; oboInOwl:hasDbXref "UMLS:C1866805", "UMLS:C4280419" ; oboInOwl:hasExactSynonym "Narrow palpebral fissure, unilateral" ; oboInOwl:hasRelatedSynonym "Unequal size of opening between the eyelids" ; oboInOwl:id "HP:0007946" ; a owl:Class ; rdfs:label "Unilateral narrow palpebral fissure" ; rdfs:subClassOf obo:HP_0000581 . obo:HP_0007947 obo:IAO_0000115 "A subtype of retinitis pigmentosa in which, instead of the pathology starting in the mid-periphery like typical retinitis pigmentosa, the disease starts in the near periphery closer to the vascular arcades and tends to spare the far periphery." ; oboInOwl:hasDbXref "MSH:C564838", "UMLS:C1849398" ; oboInOwl:id "HP:0007947" ; a owl:Class ; rdfs:label "Pericentral retinitis pigmentosa" ; rdfs:subClassOf obo:HP_0000510 . obo:HP_0007948 obo:IAO_0000115 "A type of posterior cortical cataract characterized by dense lenticular opacities." ; oboInOwl:hasDbXref "UMLS:C4024767" ; oboInOwl:id "HP:0007948" ; a owl:Class ; rdfs:label "Dense posterior cortical cataract" ; rdfs:subClassOf obo:HP_0010924 . obo:HP_0007949 oboInOwl:id "HP:0007949" ; a owl:Class ; rdfs:label "obsolete Progressive macular scarring" ; owl:deprecated true . obo:HP_0007950 obo:IAO_0000115 "Chorioretinal atrophy concentrated around the optic papilla (i.e., the optic nerve head)." ; oboInOwl:hasDbXref "UMLS:C4024765" ; oboInOwl:id "HP:0007950" ; a owl:Class ; rdfs:label "Peripapillary chorioretinal atrophy" ; rdfs:subClassOf obo:HP_0000533 . obo:HP_0007956 obo:IAO_0100001 "HP:0000567" ; oboInOwl:id "HP:0007956" ; a owl:Class ; rdfs:label "obsolete Bilateral choroid coloboma" ; owl:deprecated true . obo:HP_0007957 obo:IAO_0000115 "A reduction of corneal clarity." ; oboInOwl:hasAlternativeId "HP:0007844", "HP:0007883", "HP:0008502" ; oboInOwl:hasDbXref "MSH:D003318", "SNOMEDCT_US:413921009", "SNOMEDCT_US:64634000", "SNOMEDCT_US:95735008", "UMLS:C0010038", "UMLS:C0521719" ; oboInOwl:hasExactSynonym "Corneal clouding", "Corneal opacities", "Reduction of corneal clarity", "Scarring or clouding of the cornea of the eye" ; oboInOwl:id "HP:0007957" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Corneal opacity" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000957 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007958 oboInOwl:hasDbXref "UMLS:C4024763" ; oboInOwl:id "HP:0007958" ; a owl:Class ; rdfs:label "Optic atrophy from cranial nerve compression" ; rdfs:subClassOf obo:HP_0000648, obo:HP_0001293 . obo:HP_0007961 oboInOwl:consider "HP:0000580" ; oboInOwl:id "HP:0007961" ; a owl:Class ; rdfs:label "obsolete Rarefaction of retinal pigmentation" ; owl:deprecated true . obo:HP_0007962 oboInOwl:hasDbXref "UMLS:C4021857" ; oboInOwl:id "HP:0007962" ; a owl:Class ; rdfs:label "Speckled corneal dystrophy" ; rdfs:subClassOf obo:HP_0001131 . obo:HP_0007963 obo:IAO_0000115 "A spectrum of fundoscopic appearances characterized by the development of a variety of patterns of deposits predominantly in the macular area. The deposits are typically bilateral, relatively symmetrical, yellow/white and associated with changes at the level of the retinal pigment epithelium. With time, retinal atrophy may occur. A number of pattern dystrophy subtypes have been described including butterfly-shaped dystrophy, reticular dystrophy (net-like pattern) and fundus pulverulentus (granular, mottled pigmentation)." ; oboInOwl:hasDbXref "UMLS:C4024762" ; oboInOwl:id "HP:0007963" ; a owl:Class ; rdfs:label "Pattern dystrophy of the retina" ; rdfs:subClassOf obo:HP_0000556 . obo:HP_0007964 oboInOwl:hasDbXref "UMLS:C1843486" ; oboInOwl:id "HP:0007964" ; a owl:Class ; rdfs:label "Degenerative vitreoretinopathy" ; rdfs:subClassOf obo:HP_0007773 . obo:HP_0007965 oboInOwl:hasDbXref "UMLS:C1850069" ; oboInOwl:hasExactSynonym "Absence of visual evoked potentials", "Non-detectable VEP", "Undetectable VEP" ; oboInOwl:id "HP:0007965" ; a owl:Class ; rdfs:label "Undetectable visual evoked potentials" ; rdfs:subClassOf obo:HP_0000649 . obo:HP_0007968 obo:IAO_0000115 "Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth. This features results from a failure of regression of the hyaloid vessel, which supplies the primary vitreous during embryogenesis and normally regresses in the third trimester of pregnancy, leading to a particular form of posterior cataract." ; oboInOwl:hasDbXref "MSH:D054514", "SNOMEDCT_US:314270008", "SNOMEDCT_US:44647001", "SNOMEDCT_US:69927002", "UMLS:C0266568" ; oboInOwl:hasExactSynonym "Congenital retinal septum", "Persistent fetal vasculature", "Persistent foetal vasculature", "Persistent hyperplasia of primary vitreous", "Persistent hyperplastic primary vitreous", "Persistent hypertrophic primary vitreous", "Persistent posterior fetal fibrovascular sheath of the lens", "Persistent posterior foetal fibrovascular sheath of the lens", "Persistent tunica vasculosa lentis" ; oboInOwl:id "HP:0007968" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Remnants of the hyaloid vascular system" ; rdfs:subClassOf obo:HP_0004327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000082 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002270 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007970 oboInOwl:hasDbXref "SNOMEDCT_US:268163008", "SNOMEDCT_US:61989004", "UMLS:C0266573" ; oboInOwl:hasExactSynonym "Congenital drooping upper eyelid" ; oboInOwl:id "HP:0007970" ; a owl:Class ; rdfs:label "Congenital ptosis" ; rdfs:subClassOf obo:HP_0000508 . obo:HP_0007971 obo:IAO_0000115 "A congenital cataract in which opacity is limited to layers of the lens external to the nucleus (i.e., the perinuclear region), i.e., between the nuclear and cortical layers of the lens." ; oboInOwl:hasDbXref "SNOMEDCT_US:204128001", "SNOMEDCT_US:21590003", "UMLS:C0266537" ; oboInOwl:id "HP:0007971" ; a owl:Class ; rdfs:label "Lamellar cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0007973 obo:IAO_0000115 "The presence of developmental dysplasia of the retina." ; oboInOwl:hasAlternativeId "HP:0007901", "HP:0008022" ; oboInOwl:hasDbXref "MSH:D015792", "SNOMEDCT_US:95494009", "UMLS:C0035313" ; oboInOwl:hasExactSynonym "Retinal dysgenesis" ; oboInOwl:id "HP:0007973" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature is a congenital developmental anomaly of the retina characterized by abnormal growth and differentiation. The retina contains numerous tubular structures and rosettes. Retinal dysplasia (synonym: retinal dysgenesis) is often accompanied by retinal detachment and micropthalmos, but the latter features should be coded separately." ; rdfs:label "Retinal dysplasia" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007975 obo:IAO_0000115 "Saccadic undershoot of horizontal saccadic eye movements, i.e., a horizontal saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object." ; oboInOwl:hasDbXref "UMLS:C1856478" ; oboInOwl:id "HP:0007975" ; a owl:Class ; rdfs:label "Hypometric horizontal saccades" ; rdfs:subClassOf obo:HP_0000571 . obo:HP_0007976 obo:IAO_0000115 "Cerulean cataracts are a kind of congenital cataract having peripheral bluish and white opacifications in concentric layers with occasional central lesions arranged radially. Although the opacities may be observed during fetal development and childhood, usually visual acuity is only mildly reduced until adulthood, when lens extraction is generally necessary." ; oboInOwl:hasDbXref "MSH:C537955", "SNOMEDCT_US:204138006", "UMLS:C0344523" ; oboInOwl:hasExactSynonym "Cataracts, congenital, cerulean" ; oboInOwl:id "HP:0007976" ; a owl:Class ; rdfs:label "Cerulean cataract" ; rdfs:subClassOf obo:HP_0007648 . obo:HP_0007979 obo:IAO_0000115 "Horizontal nystagmus made apparent by looking to the right or to the left." ; oboInOwl:hasAlternativeId "HP:0007639" ; oboInOwl:hasDbXref "UMLS:C1853394" ; oboInOwl:hasExactSynonym "Nystagmus, horizontal, gaze-evoked" ; oboInOwl:hasRelatedSynonym "Nystagmus, horizontal gaze-evoked" ; oboInOwl:id "HP:0007979" ; a owl:Class ; rdfs:label "Gaze-evoked horizontal nystagmus" ; rdfs:subClassOf obo:HP_0000640, obo:HP_0000666 . obo:HP_0007980 oboInOwl:hasDbXref "UMLS:C1852548" ; oboInOwl:id "HP:0007980" ; a owl:Class ; rdfs:label "Absent retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0007894 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001782 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007981 obo:IAO_0100001 "HP:0001133" ; oboInOwl:id "HP:0007981" ; a owl:Class ; rdfs:label "obsolete Concentric narrowing of visual field" ; owl:deprecated true . obo:HP_0007982 oboInOwl:consider "HP:0000556" ; oboInOwl:id "HP:0007982" ; a owl:Class ; rdfs:label "obsolete Central tapetoretinal dystrophy" ; owl:deprecated true . obo:HP_0007984 obo:IAO_0000115 "A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave (source: Holder GE., Inherited Chorioretinal Dystrophies: A Textbook and Atlas; 2014; p.17; ISBN 978-3-540-69466-3)." ; oboInOwl:hasDbXref "UMLS:C4021561" ; oboInOwl:hasExactSynonym "Electronegative ERG", "Electroretinogram: reduced b-wave amplitude", "Reduced ERG amplitude of b-wave", "Reduced amplitude of dark-adapted bright flash electroretinogram b-wave", "Reduced electroretinogram rod b-wave" ; oboInOwl:id "HP:0007984" ; a owl:Class ; rdfs:comment "Flashes will elicit an a-wave with an initial negative deflection followed by a b-wave with positive deflection. This feature refers to a reduction in the amplitude primarily of the b-wave." ; rdfs:label "Electronegative electroretinogram" ; rdfs:subClassOf obo:HP_0030478 . obo:HP_0007985 obo:IAO_0000115 "Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina." ; oboInOwl:hasDbXref "UMLS:C4024761" ; oboInOwl:hasExactSynonym "Blocked retinal artery" ; oboInOwl:id "HP:0007985" ; a owl:Class ; rdfs:label "Retinal arteriolar occlusion" ; rdfs:subClassOf obo:HP_0000630, obo:HP_0100545 . obo:HP_0007986 oboInOwl:hasDbXref "UMLS:C1847882" ; oboInOwl:id "HP:0007986" ; a owl:Class ; rdfs:label "Increased retinal vascularity" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0007987 oboInOwl:hasDbXref "UMLS:C4024760" ; oboInOwl:id "HP:0007987" ; a owl:Class ; rdfs:label "Progressive visual field defects" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0007988 obo:IAO_0000115 "Decreased amount of pigmentation in the macula lutea." ; oboInOwl:hasDbXref "UMLS:C4024759" ; oboInOwl:id "HP:0007988" ; a owl:Class ; rdfs:label "Macular hypopigmentation" ; rdfs:subClassOf obo:HP_0008002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000053 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007989 obo:IAO_0000115 "Retinal exudate within the retinal tissue itself." ; oboInOwl:hasDbXref "UMLS:C4024758" ; oboInOwl:id "HP:0007989" ; a owl:Class ; rdfs:label "Intraretinal exudate" ; rdfs:subClassOf obo:HP_0001147 . obo:HP_0007990 obo:IAO_0000115 "Underdevelopment of the stroma of iris." ; oboInOwl:hasAlternativeId "HP:0007991", "HP:0008027" ; oboInOwl:hasDbXref "UMLS:C1860344" ; oboInOwl:hasExactSynonym "Hypoplastic iris stoma", "Iris stromal hypoplasia", "Underdeveloped iris stroma" ; oboInOwl:id "HP:0007990" ; a owl:Class ; rdfs:label "Hypoplastic iris stroma" ; rdfs:subClassOf obo:HP_0007676 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001779 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007992 oboInOwl:hasDbXref "SNOMEDCT_US:3577000", "UMLS:C0154856" ; oboInOwl:id "HP:0007992" ; a owl:Class ; rdfs:label "Lattice retinal degeneration" ; rdfs:subClassOf obo:HP_0007769 . obo:HP_0007993 obo:IAO_0000115 "Congenital malformation of the lacrimal duct associated with incomplete development of the bony nasolacrimal canal or craniofacial anomalies." ; oboInOwl:hasDbXref "UMLS:C4024757" ; oboInOwl:hasExactSynonym "Malformed tear ducts" ; oboInOwl:id "HP:0007993" ; a owl:Class ; rdfs:label "Malformed lacrimal duct" ; rdfs:subClassOf obo:HP_0011481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0007994 obo:IAO_0000115 "Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision." ; oboInOwl:hasDbXref "SNOMEDCT_US:420990001", "UMLS:C0241688", "UMLS:C2937228" ; oboInOwl:hasExactSynonym "Kalnienk vision", "Loss of peripheral vision" ; oboInOwl:hasRelatedSynonym "Tunnel vision" ; oboInOwl:id "HP:0007994" ; a owl:Class ; rdfs:label "Peripheral visual field loss" ; rdfs:subClassOf obo:HP_0001133 . obo:HP_0008000 obo:IAO_0000115 "An abnormally reduced response to stimulation of the cornea (by touch, foreign body, blowing air). The corneal reflex (also known as the blink reflex, normally results in an involuntary blinking of the eyelids." ; oboInOwl:hasDbXref "MSH:D012021", "SNOMEDCT_US:103254005", "UMLS:C0151572" ; oboInOwl:hasExactSynonym "Decreased blink reflex", "Reduced corneal reflex" ; oboInOwl:id "HP:0008000" ; a owl:Class ; rdfs:label "Decreased corneal reflex" ; rdfs:subClassOf obo:HP_0034251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000964 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008001 obo:IAO_0000115 "Increased amount of pigmentation in the fovea centralis." ; oboInOwl:hasDbXref "UMLS:C3809301" ; oboInOwl:id "HP:0008001" ; a owl:Class ; rdfs:label "Foveal hyperpigmentation" ; rdfs:subClassOf obo:HP_0030493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001786 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008002 obo:IAO_0000115 "Abnormality of macular or foveal pigmentation." ; oboInOwl:hasDbXref "UMLS:C1837087", "UMLS:C4024756" ; oboInOwl:hasRelatedSynonym "Macular pigmentary changes" ; oboInOwl:id "HP:0008002" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of macular pigmentation" ; rdfs:subClassOf obo:HP_0001103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000053 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008003 oboInOwl:hasAlternativeId "HP:0007897" ; oboInOwl:hasDbXref "UMLS:C1853558" ; oboInOwl:hasExactSynonym "Jerky smooth pursuit" ; oboInOwl:id "HP:0008003" ; a owl:Class ; rdfs:label "Jerky ocular pursuit movements" ; rdfs:subClassOf obo:HP_0000617 . obo:HP_0008005 obo:IAO_0100001 "HP:0001131" ; oboInOwl:id "HP:0008005" ; a owl:Class ; rdfs:label "obsolete Congenital corneal dystrophy" ; owl:deprecated true . obo:HP_0008007 oboInOwl:hasDbXref "SNOMEDCT_US:415176004", "UMLS:C1533041" ; oboInOwl:id "HP:0008007" ; a owl:Class ; rdfs:label "Primary congenital glaucoma" ; rdfs:subClassOf obo:HP_0001087 . obo:HP_0008008 oboInOwl:id "HP:0008008" ; a owl:Class ; rdfs:label "obsolete Progressive central visual loss" ; owl:deprecated true . obo:HP_0008009 oboInOwl:hasDbXref "UMLS:C1860785" ; oboInOwl:hasExactSynonym "Three rows of eyelashes", "Triple row of eyelashes" ; oboInOwl:id "HP:0008009" ; a owl:Class ; rdfs:label "Three rows of eyelashes" ; rdfs:subClassOf obo:HP_0008496 . obo:HP_0008011 obo:IAO_0000115 "Reduced transparency of the peripheral region of the cornea." ; oboInOwl:hasDbXref "SNOMEDCT_US:55713007", "UMLS:C0155100" ; oboInOwl:hasExactSynonym "Peripheral corneal opacity" ; oboInOwl:id "HP:0008011" ; a owl:Class ; rdfs:label "Peripheral opacification of the cornea" ; rdfs:subClassOf obo:HP_0007759 . obo:HP_0008012 oboInOwl:consider "HP:0000545" ; oboInOwl:id "HP:0008012" ; a owl:Class ; rdfs:label "obsolete Congenital myopia" ; owl:deprecated true . obo:HP_0008014 obo:IAO_0000115 "Microscopic aneurysms of the retinal arterioles near the central part of the fundus, visible as small round dark red dots on the retinal surface (not arising from visible vessels) that are by definition less than the diameter of the major optic veins as they cross the optic disc." ; oboInOwl:hasDbXref "UMLS:C4024755" ; oboInOwl:id "HP:0008014" ; a owl:Class ; rdfs:label "Central fundal arteriolar microaneurysms" ; rdfs:subClassOf obo:HP_0032416 . obo:HP_0008017 oboInOwl:consider "HP:0007680" ; oboInOwl:id "HP:0008017" ; a owl:Class ; rdfs:label "obsolete Depigmented lesions of the retinal pigment epithelium" ; owl:deprecated true . obo:HP_0008019 obo:IAO_0000115 "Partial dislocation of the lens in a superior direction." ; oboInOwl:hasDbXref "UMLS:C2036843" ; oboInOwl:hasExactSynonym "Superior subluxated lens" ; oboInOwl:id "HP:0008019" ; a owl:Class ; rdfs:label "Superior lens subluxation" ; rdfs:subClassOf obo:HP_0001132 . obo:HP_0008020 obo:IAO_0000115 "Inherited progressive cone degeneration." ; oboInOwl:hasAlternativeId "HP:0007789" ; oboInOwl:hasDbXref "UMLS:C0730290", "UMLS:C3665342" ; oboInOwl:hasExactSynonym "Progressive cone degeneration", "Progressive cone dystrophy" ; oboInOwl:id "HP:0008020" ; a owl:Class ; rdfs:label "Cone dystrophy" ; rdfs:subClassOf obo:HP_0000548 . obo:HP_0008024 obo:IAO_0100001 "HP:0100018" ; oboInOwl:id "HP:0008024" ; a owl:Class ; rdfs:label "obsolete Congenital nuclear cataract" ; owl:deprecated true . obo:HP_0008026 oboInOwl:hasDbXref "UMLS:C4024754" ; oboInOwl:id "HP:0008026" ; a owl:Class ; rdfs:label "Horizontal opticokinetic nystagmus" ; rdfs:subClassOf obo:HP_0000666 . obo:HP_0008028 obo:IAO_0000115 "A form of macular degeneration characterized by the presence of multiple cysts in the macula." ; oboInOwl:hasAlternativeId "HP:0007673" ; oboInOwl:hasDbXref "SNOMEDCT_US:14046000", "UMLS:C0154850" ; oboInOwl:hasExactSynonym "Cystic macular degeneration" ; oboInOwl:id "HP:0008028" ; a owl:Class ; rdfs:label "Cystoid macular degeneration" ; rdfs:subClassOf obo:HP_0000608 . obo:HP_0008030 oboInOwl:hasDbXref "SNOMEDCT_US:11255009", "UMLS:C0271069" ; oboInOwl:id "HP:0008030" ; a owl:Class ; rdfs:label "Retinal arteritis" ; rdfs:subClassOf obo:HP_0000630, obo:HP_0012089, obo:HP_0025188 . obo:HP_0008031 obo:IAO_0000115 "A type of sutural cataract in which the opacity follows the posterior Y suture." ; oboInOwl:hasDbXref "UMLS:C4021560" ; oboInOwl:hasExactSynonym "Posterior Y-sutural cataracts" ; oboInOwl:id "HP:0008031" ; a owl:Class ; rdfs:label "Posterior Y-sutural cataract" ; rdfs:subClassOf obo:HP_0010695 . obo:HP_0008033 obo:IAO_0100001 "HP:0000577" ; oboInOwl:id "HP:0008033" ; a owl:Class ; rdfs:label "obsolete Congenital exotropia" ; owl:deprecated true . obo:HP_0008034 obo:IAO_0000115 "Abnormal pigmentation of the iris." ; oboInOwl:hasDbXref "UMLS:C1834387" ; oboInOwl:id "HP:0008034" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal iris pigmentation" ; rdfs:subClassOf obo:HP_0000525 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008035 obo:IAO_0000115 "Retinitis pigmentosa inversa is form of retinal degeneration characterized by areas of retinal/chorioretinal degeneration with pigment migration in the macular area (in contrast to retinitis pigmentosa which, at early disease stages, predominantly affects the retinal periphery)." ; oboInOwl:hasAlternativeId "HP:0008506" ; oboInOwl:hasDbXref "UMLS:C4021559" ; oboInOwl:hasExactSynonym "Central retinitis pigmentosa" ; oboInOwl:id "HP:0008035" ; a owl:Class ; rdfs:label "Retinitis pigmentosa inversa" ; rdfs:subClassOf obo:HP_0000546 . obo:HP_0008036 oboInOwl:id "HP:0008036" ; a owl:Class ; rdfs:label "obsolete Rod-cone dystrophy" ; owl:deprecated true . obo:HP_0008037 obo:IAO_0000115 "Absence of the anterior chamber of the eye owing to a developmental defect." ; oboInOwl:hasDbXref "SNOMEDCT_US:404675003", "SNOMEDCT_US:55457007", "UMLS:C0271004" ; oboInOwl:id "HP:0008037" ; a owl:Class ; rdfs:label "Absent anterior chamber of the eye" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0008038 obo:IAO_0000115 "Absence or underdevelopment of the lacrimal gland." ; oboInOwl:hasDbXref "UMLS:C1835602" ; oboInOwl:hasExactSynonym "Absent/underdeveloped lacrimal glands", "Absent/underdeveloped tear glands" ; oboInOwl:id "HP:0008038" ; a owl:Class ; rdfs:label "Aplastic/hypoplastic lacrimal glands" ; rdfs:subClassOf obo:HP_0011482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008039 oboInOwl:hasDbXref "UMLS:C1857307" ; oboInOwl:id "HP:0008039" ; a owl:Class ; rdfs:label "Subepithelial corneal opacities" ; rdfs:subClassOf obo:HP_0007727 . obo:HP_0008041 oboInOwl:hasDbXref "UMLS:C1856441" ; oboInOwl:id "HP:0008041" ; a owl:Class ; rdfs:label "Late onset congenital glaucoma" ; rdfs:subClassOf obo:HP_0001087 . obo:HP_0008043 obo:IAO_0000115 "Decreased retinal arteriolar diameters, which may decrease blood flow and slow oxygen delivery to regions of the retina." ; oboInOwl:hasAlternativeId "HP:0007952", "HP:0008510" ; oboInOwl:hasDbXref "UMLS:C2176208" ; oboInOwl:hasExactSynonym "Constricted retinal arterioles", "Narrow retinal arterioles", "Retinal arteriolar narrowing" ; oboInOwl:id "HP:0008043" ; a owl:Class ; rdfs:comment "Usually after the first branch, the retinal arteries contain no elastic fibers and the term retinal arteriole is more appropriate. The main changes seen in diseases such as hypertension affect mainly the retinal arterioles rather than the retinal artery." ; rdfs:label "Retinal arteriolar constriction" ; rdfs:subClassOf obo:HP_0000630 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008045 oboInOwl:hasDbXref "UMLS:C4021558" ; oboInOwl:hasExactSynonym "High flash visual evoked potentials" ; oboInOwl:id "HP:0008045" ; a owl:Class ; rdfs:label "Enlarged flash visual evoked potentials" ; rdfs:subClassOf obo:HP_0030462 . obo:HP_0008046 obo:IAO_0000115 "A structural abnormality of retinal vasculature." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T12:09:00Z" ; oboInOwl:hasDbXref "UMLS:C4024753" ; oboInOwl:hasExactSynonym "Abnormality of retina blood vessels", "Abnormality of the retinal vasculature" ; oboInOwl:id "HP:0008046" ; a owl:Class ; rdfs:label "Abnormal retinal vascular morphology" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0008047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008047 dcterms:creator ; oboInOwl:creation_date "2008-04-02T12:10:00Z" ; oboInOwl:hasDbXref "UMLS:C4024752" ; oboInOwl:hasExactSynonym "Abnormality of eye blood vessels" ; oboInOwl:id "HP:0008047" ; a owl:Class ; rdfs:label "Abnormality of the vasculature of the eye" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008048 obo:IAO_0000115 "An abnormality of the line of Schwalbe." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T12:12:00Z" ; oboInOwl:hasDbXref "UMLS:C4021856" ; oboInOwl:hasExactSynonym "Abnormality of the line of Schwalbe" ; oboInOwl:id "HP:0008048" ; a owl:Class ; rdfs:comment "Schwalbe's line is the anatomical line found on the posterior surface of the cornea, delineating the outer limit of the corneal endothelium layer." ; rdfs:label "Abnormal line of Schwalbe morphology" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011918 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008049 obo:IAO_0000115 "An abnormality of an extraocular muscle." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T12:14:00Z" ; oboInOwl:hasDbXref "UMLS:C4024751" ; oboInOwl:id "HP:0008049" ; a owl:Class ; rdfs:comment "There are six extraocular muscles that control the movements of the eye." ; rdfs:label "Abnormality of the extraocular muscles" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008050 obo:IAO_0000115 "An anomaly of the space between the medial and lateral canthi of the two open eyelids." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T01:22:00Z" ; oboInOwl:hasDbXref "UMLS:C4024750" ; oboInOwl:hasExactSynonym "Abnormality of the opening between the eyelids", "Abnormality of the palpebral fissures" ; oboInOwl:hasNarrowSynonym "Deformity of the palpebral fissures", "Malformation of the palpebral fissures" ; oboInOwl:id "HP:0008050" ; a owl:Class ; rdfs:label "Abnormality of the palpebral fissures" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008051 obo:IAO_0100001 "HP:0007703" ; oboInOwl:id "HP:0008051" ; a owl:Class ; rdfs:label "obsolete Abnormality of the retinal pigment epithelium" ; owl:deprecated true . obo:HP_0008052 obo:IAO_0000115 "A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T01:37:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:37480005", "UMLS:C0229197" ; oboInOwl:hasExactSynonym "Retinal folds" ; oboInOwl:id "HP:0008052" ; a owl:Class ; rdfs:label "Retinal fold" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0008053 obo:IAO_0000115 "Absence or underdevelopment of the iris." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T01:50:00Z" ; oboInOwl:hasDbXref "UMLS:C4024748" ; oboInOwl:hasExactSynonym "Absent/small iris", "Absent/underdeveloped iris" ; oboInOwl:id "HP:0008053" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the iris" ; rdfs:subClassOf obo:HP_0000525, obo:HP_0008055, obo:HP_0008062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008054 obo:IAO_0000115 "Any abnormality of the blood vessels of the conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4024747" ; oboInOwl:hasExactSynonym "Abnormal morphology of the conjunctiva vasculature", "Abnormal vasculature of the conjunctiva morphology", "Abnormality of the vasculature of the conjunctiva" ; oboInOwl:id "HP:0008054" ; a owl:Class ; rdfs:label "Abnormal morphology of the conjunctival vasculature" ; rdfs:subClassOf obo:HP_0000502, obo:HP_0008047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008055 obo:IAO_0000115 "Absence or underdevelopment of the uvea, the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:24:00Z" ; oboInOwl:hasDbXref "UMLS:C4024746" ; oboInOwl:hasExactSynonym "Absent/underdeveloped uvea" ; oboInOwl:id "HP:0008055" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia affecting the uvea" ; rdfs:subClassOf obo:HP_0000553, obo:HP_0008056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001768 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008056 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:25:00Z" ; oboInOwl:hasDbXref "UMLS:C4024745" ; oboInOwl:hasExactSynonym "Absent/small eye", "Absent/underdeveloped eye" ; oboInOwl:id "HP:0008056" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia affecting the eye" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008057 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:27:00Z" ; oboInOwl:hasDbXref "UMLS:C4024744" ; oboInOwl:hasExactSynonym "Absent/small fundus" ; oboInOwl:id "HP:0008057" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia affecting the fundus" ; rdfs:subClassOf obo:HP_0001098, obo:HP_0008056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003951 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008058 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:28:00Z" ; oboInOwl:hasDbXref "UMLS:C4024743" ; oboInOwl:hasExactSynonym "Absent/small optic nerve", "Absent/underdeveloped optic nerve" ; oboInOwl:id "HP:0008058" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the optic nerve" ; rdfs:subClassOf obo:HP_0000587, obo:HP_0008057 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008059 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4024742" ; oboInOwl:hasExactSynonym "Absent/underdeveloped macula" ; oboInOwl:id "HP:0008059" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the macula" ; rdfs:subClassOf obo:HP_0001103, obo:HP_0008061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008060 obo:IAO_0000115 "Congenital absence or underdevelopment of the fovea centralis." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:30:00Z" ; oboInOwl:hasDbXref "UMLS:C4024741" ; oboInOwl:hasExactSynonym "Absent/underdeveloped fovea" ; oboInOwl:id "HP:0008060" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the fovea" ; rdfs:subClassOf obo:HP_0000493, obo:HP_0008059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008061 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:30:00Z" ; oboInOwl:hasDbXref "UMLS:C4024740" ; oboInOwl:hasExactSynonym "Absent/small retina", "Absent/underdeveloped retina" ; oboInOwl:id "HP:0008061" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the retina" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0008057 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008062 obo:IAO_0000115 "Absence or underdevelopment of the anterior segment of the eye." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4024739" ; oboInOwl:id "HP:0008062" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia affecting the anterior segment of the eye" ; rdfs:subClassOf obo:HP_0007700, obo:HP_0008056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001801 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008063 obo:IAO_0000115 "Absence or underdevelopment of the lens." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4024738" ; oboInOwl:hasExactSynonym "Absent/small lens", "Absent/underdeveloped lens" ; oboInOwl:id "HP:0008063" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the lens" ; rdfs:subClassOf obo:HP_0000517, obo:HP_0008062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008064 obo:IAO_0000115 "An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:41:00Z" ; oboInOwl:hasAlternativeId "HP:0000955", "HP:0007547" ; oboInOwl:hasDbXref "MEDDRA:10021198", "MSH:D007057", "UMLS:C0020757" ; oboInOwl:hasExactSynonym "Ichthyosiform abnormality of the skin", "Ichthyotic skin" ; oboInOwl:hasRelatedSynonym "Hypertrophic ichthyosis" ; oboInOwl:id "HP:0008064" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The ichthyoses are a group of skin diseases characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed. The abnormality in ichthyosis lies in am imbalance in the normal lifecycle of skin in which growth is matched with dying and shedding of skin cells. In ichthyosis, skin cells reproduce at a rate faster than dead skin cells can be shed or reproduce at a normal rate with a reduction in the rate of shedding. Either abnormality leads to a build up of dry and scaly skin. Note that this term refers to the morphological abnormality of the skin and not the disorder." ; rdfs:label "Ichthyosis" ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0008065 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4024737" ; oboInOwl:hasExactSynonym "Absent/small skin", "Absent/underdeveloped skin" ; oboInOwl:id "HP:0008065" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the skin" ; rdfs:subClassOf obo:HP_0011355 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008066 obo:IAO_0000115 "The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:54:00Z" ; oboInOwl:hasAlternativeId "HP:0007467", "HP:0007496", "HP:0200038" ; oboInOwl:hasDbXref "UMLS:C0241054", "UMLS:C2132198", "UMLS:C2220104" ; oboInOwl:hasExactSynonym "Abnormal blistering of the skin", "Blister", "Blistering, generalised", "Blistering, generalized", "Blisters", "Skin bullae" ; oboInOwl:hasRelatedSynonym "Skin blisters" ; oboInOwl:id "HP:0008066" ; a owl:Class ; rdfs:comment "A bulla is a large vesicle described as a rounded or irregularly shaped blister containing serous or seropurulent fluid, equal to or greater than 10mm. In approaching blistering diseases, there are 3 fundamental criteria to consider: (1) the site or level of the blister (or the lowest level of vesiculation): subcorneal, midepidermis, suprabasal, subepidermal; (2) the findings that implicate the mechanism of blister formation (spongiosis, acantholysis, blistering degeneration, or epidermolysis); and (3) the type of inflammation (neutrophilic, lymphocytic, eosinophilic, mixed), if present." ; rdfs:label "Abnormal blistering of the skin" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001928 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008067 dcterms:creator ; oboInOwl:creation_date "2008-04-02T03:56:00Z" ; oboInOwl:hasDbXref "UMLS:C4024736" ; oboInOwl:hasExactSynonym "Abnormally loose or hyperelastic skin", "Abnormally loose or stretchable skin" ; oboInOwl:id "HP:0008067" ; a owl:Class ; rdfs:label "Abnormally lax or hyperextensible skin" ; rdfs:subClassOf obo:HP_0010647 . obo:HP_0008069 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the skin." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T04:01:00Z" ; oboInOwl:hasBroadSynonym "Skin cancer (non-melanoma)" ; oboInOwl:hasDbXref "MSH:D012878", "NCIT:C3262", "SNOMEDCT_US:126488004", "SNOMEDCT_US:372130007", "UMLS:C0007114", "UMLS:C0037286" ; oboInOwl:hasExactSynonym "Dermatological tumors", "Dermatological tumours", "Skin tumors", "Skin tumours", "Tumor of the skin", "Tumour of the skin" ; oboInOwl:hasRelatedSynonym "Neoplasia of the skin", "Skin cancer" ; oboInOwl:id "HP:0008069" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Neoplasm of the skin" ; rdfs:subClassOf obo:HP_0000951, obo:HP_0011793 . obo:HP_0008070 obo:IAO_0000115 "Reduced density of hairs." ; dcterms:creator ; oboInOwl:creation_date "2008-04-02T04:11:00Z" ; oboInOwl:hasAlternativeId "HP:0001006", "HP:0002237", "HP:0002291", "HP:0002551", "HP:0004522", "HP:0004525", "HP:0004538", "HP:0004874" ; oboInOwl:hasDbXref "MEDDRA:10021126", "MSH:D007039", "SNOMEDCT_US:53602002", "SNOMEDCT_US:56558005", "UMLS:C0020678", "UMLS:C1837770", "UMLS:C1860844" ; oboInOwl:hasExactSynonym "Decreased hair growth", "Decreased hair growth on body", "Hypotrichosis", "Marked hypotrichosis", "Sparse hair", "Sparse hair since birth" ; oboInOwl:hasRelatedSynonym "Thin, sparse hair" ; oboInOwl:id "HP:0008070" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term applies if the number of hair shafts per unit area is reduced. The term fine hair is used to describe hair with a reduced diameter." ; rdfs:label "Sparse hair" ; rdfs:subClassOf obo:HP_0011362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008071 obo:IAO_0000115 "Increased blood pressure during a pregnancy." ; oboInOwl:hasDbXref "SNOMEDCT_US:288250001", "UMLS:C0565599" ; oboInOwl:id "HP:0008071" ; a owl:Class ; rdfs:label "Maternal hypertension" ; rdfs:subClassOf obo:HP_0100603 . obo:HP_0008072 obo:IAO_0000115 "Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum." ; oboInOwl:hasDbXref "UMLS:C4024735" ; oboInOwl:id "HP:0008072" ; a owl:Class ; rdfs:label "Maternal virilization in pregnancy" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0008073 obo:IAO_0000115 "An abnormally low concentration of serum conjugated estriol as compared to normal values for gestational-age." ; oboInOwl:hasDbXref "UMLS:C4024734" ; oboInOwl:hasExactSynonym "Low maternal serum estriol" ; oboInOwl:id "HP:0008073" ; a owl:Class ; rdfs:label "Low maternal circulating estriol concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0008074 oboInOwl:hasDbXref "UMLS:C1834349" ; oboInOwl:id "HP:0008074" ; a owl:Class ; rdfs:label "Metatarsal periosteal thickening" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0030313 . obo:HP_0008075 obo:IAO_0100001 "HP:0001761" ; oboInOwl:id "HP:0008075" ; a owl:Class ; rdfs:label "obsolete Progressive pes cavus" ; owl:deprecated true . obo:HP_0008076 obo:IAO_0000115 "Reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." ; oboInOwl:hasDbXref "UMLS:C1836872" ; oboInOwl:id "HP:0008076" ; a owl:Class ; rdfs:label "Osteoporotic tarsals" ; rdfs:subClassOf obo:HP_0009132 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001562 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0008078 oboInOwl:hasDbXref "UMLS:C1850162" ; oboInOwl:id "HP:0008078" ; a owl:Class ; rdfs:label "Thin metatarsal cortices" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0008079 obo:IAO_0000115 "A developmental abnormality characterized by the absence of the fifth metatarsal bone." ; oboInOwl:hasAlternativeId "HP:0010670" ; oboInOwl:hasDbXref "UMLS:C1867932" ; oboInOwl:hasExactSynonym "Absent 5th long bone of foot", "Absent 5th metatarsals", "Aplasia of the fifth metatarsal bone" ; oboInOwl:id "HP:0008079" ; a owl:Class ; rdfs:label "Absent fifth metatarsal" ; rdfs:subClassOf obo:HP_0010744 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003654 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008080 obo:IAO_0000115 "Medial deviation of the great toe owing to a deformity of the great toe joint causing the hallux to deviate medially." ; oboInOwl:hasDbXref "MSH:D050488", "SNOMEDCT_US:274147008", "UMLS:C0546297" ; oboInOwl:hasExactSynonym "Medially deviated halluces" ; oboInOwl:id "HP:0008080" ; a owl:Class ; rdfs:label "Hallux varus" ; rdfs:subClassOf obo:HP_0010051 . obo:HP_0008081 obo:IAO_0000115 "An outward deviation of the foot at the talocalcaneal or subtalar joint." ; oboInOwl:hasDbXref "SNOMEDCT_US:249803006", "SNOMEDCT_US:275344002", "UMLS:C1578482" ; oboInOwl:hasExactSynonym "Valgus foot deformity" ; oboInOwl:id "HP:0008081" ; a owl:Class ; rdfs:comment "Valgus refers to the twisting outward of a bone or joint is twisted outward from the center of the body, whereas varus is a twisting toward the center of the body." ; rdfs:label "Pes valgus" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0008082 oboInOwl:hasDbXref "UMLS:C2673401" ; oboInOwl:id "HP:0008082" ; a owl:Class ; rdfs:label "Medial deviation of the foot" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0008083 oboInOwl:hasDbXref "UMLS:C1861376" ; oboInOwl:hasExactSynonym "Underdeveloped 2nd-5th middle toe bones" ; oboInOwl:id "HP:0008083" ; a owl:Class ; rdfs:label "2nd-5th toe middle phalangeal hypoplasia" ; rdfs:subClassOf obo:HP_0003795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010357 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010369 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010381 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010393 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008087 obo:IAO_0000115 "The presence of a fifth metatarsal bone that has not undergone ossification at an age when ossification is usually visible." ; oboInOwl:hasDbXref "UMLS:C1844712" ; oboInOwl:id "HP:0008087" ; a owl:Class ; rdfs:label "Nonossified fifth metatarsal" ; rdfs:subClassOf obo:HP_0008371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003654 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008089 obo:IAO_0000115 "An anomaly of the fifth metatarsal bone." ; oboInOwl:hasDbXref "UMLS:C4024733" ; oboInOwl:hasExactSynonym "Abnormality of the 5th long bone of foot" ; oboInOwl:id "HP:0008089" ; a owl:Class ; rdfs:label "Abnormality of the fifth metatarsal bone" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003654 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008090 oboInOwl:hasDbXref "UMLS:C4024732" ; oboInOwl:id "HP:0008090" ; a owl:Class ; rdfs:label "Ankylosis of feet small joints" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0031013 . obo:HP_0008093 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the fourth toe." ; oboInOwl:hasDbXref "UMLS:C1862083" ; oboInOwl:hasExactSynonym "Short 4th toe", "Short fourth toe" ; oboInOwl:id "HP:0008093" ; a owl:Class ; rdfs:label "Short 4th toe" ; rdfs:subClassOf obo:HP_0001831 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008094 obo:IAO_0000115 "An overall widening of the spaces between the digits." ; oboInOwl:hasAlternativeId "HP:0008077" ; oboInOwl:hasDbXref "UMLS:C1969238" ; oboInOwl:hasExactSynonym "Widely spaced toes" ; oboInOwl:id "HP:0008094" ; a owl:Class ; rdfs:comment "This description is based on the width of the gap between the toes. It is usually used when the width of the toes remains normal rather than to describe a situation where the toes are thin or narrow. This term should not be used for the situation where the finding is limited to a gap between T1,2 (see Sandal gap)." ; rdfs:label "Widely spaced toes" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0008095 obo:IAO_0000115 "Osteolysis affecting the talus." ; oboInOwl:hasDbXref "UMLS:C4021556" ; oboInOwl:hasExactSynonym "Osteolysis of tali" ; oboInOwl:id "HP:0008095" ; a owl:Class ; rdfs:label "Osteolysis of talus" ; rdfs:subClassOf obo:HP_0008365, obo:HP_0009134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008096 obo:IAO_0000115 "Medial deviation of the second toe." ; oboInOwl:hasDbXref "UMLS:C1862147" ; oboInOwl:id "HP:0008096" ; a owl:Class ; rdfs:label "Medially deviated second toe" ; rdfs:subClassOf obo:HP_0010326 . obo:HP_0008097 oboInOwl:hasDbXref "UMLS:C1844520" ; oboInOwl:id "HP:0008097" ; a owl:Class ; rdfs:label "Partial fusion of tarsals" ; rdfs:subClassOf obo:HP_0008368 . obo:HP_0008102 oboInOwl:hasDbXref "UMLS:C1969289" ; oboInOwl:id "HP:0008102" ; a owl:Class ; rdfs:label "Expanded metatarsals with widened medullary cavities" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0008103 obo:IAO_0000115 "Delayed maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." ; oboInOwl:hasAlternativeId "HP:0008145" ; oboInOwl:hasDbXref "UMLS:C1846853", "UMLS:C4280418" ; oboInOwl:hasExactSynonym "Tarsal delayed ossification" ; oboInOwl:hasRelatedSynonym "Delayed ankle bone maturation" ; oboInOwl:id "HP:0008103" ; a owl:Class ; rdfs:label "Delayed tarsal ossification" ; rdfs:subClassOf obo:HP_0008369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008107 obo:IAO_0000115 "The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot located between the first and second toe." ; oboInOwl:hasDbXref "UMLS:C1867132" ; oboInOwl:id "HP:0008107" ; a owl:Class ; rdfs:label "Plantar crease between first and second toes" ; rdfs:subClassOf obo:HP_0001869 . obo:HP_0008108 obo:IAO_0000115 "Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." ; oboInOwl:hasAlternativeId "HP:0008137" ; oboInOwl:hasDbXref "UMLS:C1849293", "UMLS:C4280417" ; oboInOwl:hasExactSynonym "Precociously ossified tarsal bones" ; oboInOwl:hasRelatedSynonym "Accelerated ankle bone maturation" ; oboInOwl:id "HP:0008108" ; a owl:Class ; rdfs:label "Advanced tarsal ossification" ; rdfs:subClassOf obo:HP_0008369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008110 oboInOwl:hasDbXref "MSH:D003025", "SNOMEDCT_US:249808002", "SNOMEDCT_US:397932003", "UMLS:C0009081" ; oboInOwl:id "HP:0008110" ; a owl:Class ; rdfs:label "Equinovarus deformity" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0008111 oboInOwl:hasDbXref "UMLS:C1863403" ; oboInOwl:hasExactSynonym "Broad distal big toe" ; oboInOwl:id "HP:0008111" ; a owl:Class ; rdfs:label "Broad distal hallux" ; rdfs:subClassOf obo:HP_0010055 . obo:HP_0008112 obo:IAO_0000115 "A type of contracture in which the plantar flexion muscles are contracted." ; oboInOwl:hasDbXref "UMLS:C1861239" ; oboInOwl:hasExactSynonym "Plantar flexion contractures" ; oboInOwl:id "HP:0008112" ; a owl:Class ; rdfs:comment "Plantar flexion is the movement of the top of the foot away from the leg in a downward motion. With plantar flexion contracture, the abiliuty to passively or actively move the tip of the toe back closer to the leg is limited." ; rdfs:label "Plantar flexion contracture" ; rdfs:subClassOf obo:HP_0034677 . obo:HP_0008113 oboInOwl:hasDbXref "UMLS:C1861873" ; oboInOwl:id "HP:0008113" ; a owl:Class ; rdfs:label "Multiple plantar creases" ; rdfs:subClassOf obo:HP_0100872 . obo:HP_0008114 obo:IAO_0000115 "Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones." ; oboInOwl:hasDbXref "UMLS:C1840420" ; oboInOwl:id "HP:0008114" ; a owl:Class ; rdfs:label "Metatarsal diaphyseal endosteal sclerosis" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0001832, obo:HP_0100925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009859 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013774 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008115 obo:IAO_0000115 "Bending or curvature of a third toe in the tibial direction (i.e., towards the big toe)." ; oboInOwl:hasBroadSynonym "Curvature of 3rd toe" ; oboInOwl:hasDbXref "UMLS:C4021555", "UMLS:C4280416" ; oboInOwl:hasExactSynonym "3rd toe clinodactyly" ; oboInOwl:id "HP:0008115" ; a owl:Class ; rdfs:label "Clinodactyly of the 3rd toe" ; rdfs:subClassOf obo:HP_0001863, obo:HP_0010332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008116 obo:IAO_0000115 "Limitation of the ability to bend the toes." ; oboInOwl:hasDbXref "UMLS:C4024731" ; oboInOwl:id "HP:0008116" ; a owl:Class ; rdfs:label "Flexion limitation of toes" ; rdfs:subClassOf obo:HP_0001436 . obo:HP_0008117 oboInOwl:hasDbXref "UMLS:C1843985" ; oboInOwl:id "HP:0008117" ; a owl:Class ; rdfs:label "Shortening of the talar neck" ; rdfs:subClassOf obo:HP_0008365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0015180 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008119 oboInOwl:hasDbXref "UMLS:C1856746" ; oboInOwl:hasExactSynonym "Deformed ankle bones" ; oboInOwl:id "HP:0008119" ; a owl:Class ; rdfs:label "Deformed tarsal bones" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008122 obo:IAO_0000115 "Synostosis of the calcaneus with the navicular bone." ; oboInOwl:hasDbXref "UMLS:C4024730" ; oboInOwl:id "HP:0008122" ; a owl:Class ; rdfs:label "Calcaneonavicular fusion" ; rdfs:subClassOf obo:HP_0008368 . obo:HP_0008124 obo:IAO_0000115 "A congenital deformity characterized by a dorsiflexed, inverted, and adducted foot, i.e., a combination of talipes calcaneus and talipes varus." ; oboInOwl:hasDbXref "MSH:D000070558", "SNOMEDCT_US:30449003", "UMLS:C0265646" ; oboInOwl:id "HP:0008124" ; a owl:Class ; rdfs:label "Talipes calcaneovarus" ; rdfs:subClassOf obo:HP_0001883 . obo:HP_0008125 oboInOwl:hasDbXref "UMLS:C1859224" ; oboInOwl:id "HP:0008125" ; a owl:Class ; rdfs:label "Second metatarsal posteriorly placed" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0008127 obo:IAO_0000115 "A two-part calcaneus, a finding that probably results from delayed coalescence of two primary calcaneal centers of ossification." ; oboInOwl:hasAlternativeId "HP:0008104", "HP:0008130", "HP:0008146" ; oboInOwl:hasDbXref "UMLS:C1835574" ; oboInOwl:hasExactSynonym "Delayed coalescence of bipartite calcanei", "Delayed coalescence of calcaneal ossification centers", "Delayed coalescence of calcaneal ossification centres", "Delayed fusion of bipartite calcanei", "Double calcaneal ossification center", "Double calcaneal ossification centre", "Extra calcaneal ossification center", "Extra calcaneal ossification centre" ; oboInOwl:id "HP:0008127" ; a owl:Class ; rdfs:label "Bipartite calcaneus" ; rdfs:subClassOf obo:HP_0008364 . obo:HP_0008131 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones." ; oboInOwl:hasDbXref "UMLS:C1844848" ; oboInOwl:hasExactSynonym "Punctate calcifications of tarsals", "Punctate tarsal calcification" ; oboInOwl:id "HP:0008131" ; a owl:Class ; rdfs:label "Tarsal stippling" ; rdfs:subClassOf obo:HP_0008369, obo:HP_0010766, obo:HP_0031051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0008132 oboInOwl:hasDbXref "UMLS:C3805726" ; oboInOwl:id "HP:0008132" ; a owl:Class ; rdfs:label "Medial rotation of the medial malleolus" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0008133 oboInOwl:hasDbXref "UMLS:C4024729" ; oboInOwl:id "HP:0008133" ; a owl:Class ; rdfs:label "Distal tapering of metatarsals" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0008134 obo:IAO_0000115 "Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." ; oboInOwl:hasAlternativeId "HP:0008140" ; oboInOwl:hasDbXref "UMLS:C4021554", "UMLS:C4280415" ; oboInOwl:hasExactSynonym "Irregular tarsal centers", "Irregular tarsal centres" ; oboInOwl:hasRelatedSynonym "Irregular ankle bone maturation" ; oboInOwl:id "HP:0008134" ; a owl:Class ; rdfs:label "Irregular tarsal ossification" ; rdfs:subClassOf obo:HP_0008369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000330 obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008138 obo:IAO_0000115 "Abnormal plantar flexion of the calcaneus relative to the longitudinal axis of the tibia. This results in the angle between the long axis of the tibia and the long axis of the heel bone (calcaneus) being greater than 90 degrees." ; oboInOwl:hasDbXref "UMLS:C1860449" ; oboInOwl:hasExactSynonym "Equinus deformity of the calcaneus", "Hindfoot equinus" ; oboInOwl:id "HP:0008138" ; a owl:Class ; rdfs:label "Equinus calcaneus" ; rdfs:subClassOf obo:HP_0008364 . obo:HP_0008141 oboInOwl:hasDbXref "SNOMEDCT_US:263030002", "UMLS:C0434717" ; oboInOwl:hasExactSynonym "Dislocation of toes" ; oboInOwl:id "HP:0008141" ; a owl:Class ; rdfs:label "Dislocation of toes" ; rdfs:subClassOf obo:HP_0001780, obo:HP_0030311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008142 obo:IAO_0000115 "Delayed maturation and calcification of the calcaneus." ; oboInOwl:hasDbXref "UMLS:C4024728", "UMLS:C4280414" ; oboInOwl:hasRelatedSynonym "Delayed heel bone maturation" ; oboInOwl:id "HP:0008142" ; a owl:Class ; rdfs:label "Delayed calcaneal ossification" ; rdfs:subClassOf obo:HP_0008103, obo:HP_0008364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001450 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008144 oboInOwl:hasDbXref "UMLS:C1843986" ; oboInOwl:id "HP:0008144" ; a owl:Class ; rdfs:label "Flattening of the talar dome" ; rdfs:subClassOf obo:HP_0001850 . obo:HP_0008148 obo:IAO_0000115 "Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine." ; oboInOwl:hasDbXref "UMLS:C4024727" ; oboInOwl:id "HP:0008148" ; a owl:Class ; rdfs:label "Impaired epinephrine-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0008150 obo:IAO_0000115 "Elevations of the levels of SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) that occur during infections." ; oboInOwl:hasDbXref "UMLS:C1864179" ; oboInOwl:id "HP:0008150" ; a owl:Class ; rdfs:label "Elevated serum transaminases during infections" ; rdfs:subClassOf obo:HP_0002910 . obo:HP_0008151 obo:IAO_0000115 "Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." ; oboInOwl:hasAlternativeId "HP:0012201" ; oboInOwl:hasDbXref "SNOMEDCT_US:409674002", "UMLS:C0151872" ; oboInOwl:hasExactSynonym "Increased INR", "Increased international normalised ratio", "Increased international normalized ratio", "Low factor II activity", "Prolonged PT", "Reduced factor II activity", "Reduced prothrombin activity", "increased international normalised ratio" ; oboInOwl:id "HP:0008151" ; a owl:Class ; rdfs:comment "The prothrombin time (PT) and the activated partial thromboplastin time (APTT) are the most requested tests to investigate patients with congenital or acquired coagulopathies and drug monitoring. They are defined as the time (seconds) needed to clot platelet-poor plasma upon addition of coagulation triggers, such as tissue factor in complex with phospholipids and calcium chloride (in the PT), or negatively charged phospholipids-activators and calcium chloride (in the APTT). They can hence be considered as global coagulation tests sensitive to deficiencies of many coagulation factors. In brief, they are both sensitive to factor X, V, II and fibrinogen, whereas the PT is only sensitive to factor VII deficiency and the APTT is sensitive to pre-kallikrein, high molecular weight kininogen (HMWK), factor XII, XI, IX and VIII deficiencies. Normal plasma in the PT clots approximately within 10-12 s upon triggering coagulation, and the normal reference range is (usually) narrow. PT results have been reported as clotting time, percentage activity, PT-ratio (patient-to-normal clotting time) and as international normalized ratio (INR). The INR scale has been devised to harmonize results stemming from different thromboplastins from patients on treatment with vitamin K antagonists. Some recommend abandoning the approach of using percentage activity to assess PR." ; rdfs:label "Prolonged prothrombin time" ; rdfs:subClassOf obo:HP_0032199 . obo:HP_0008153 obo:IAO_0000115 "Episodes of muscle weakness associated with reduced levels of potassium in the blood." ; oboInOwl:hasDbXref "UMLS:C4021553" ; oboInOwl:hasExactSynonym "Hypokalemic periodic paresis" ; oboInOwl:id "HP:0008153" ; a owl:Class ; rdfs:label "Periodic hypokalemic paresis" ; rdfs:subClassOf obo:HP_0003768 . obo:HP_0008155 obo:IAO_0000115 "Excessive amounts of mucopolysaccharide in the urine." ; oboInOwl:hasAlternativeId "HP:0003567" ; oboInOwl:hasDbXref "UMLS:C4024726" ; oboInOwl:id "HP:0008155" ; a owl:Class ; rdfs:comment "This finding is suggestive of the diagnosis of a mucopolysaccharidosis." ; rdfs:label "Mucopolysacchariduria" ; rdfs:subClassOf obo:HP_0003541 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_37395 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008158 obo:IAO_0000115 "Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein." ; oboInOwl:hasDbXref "MSH:D006950", "SNOMEDCT_US:238040008", "SNOMEDCT_US:299465007", "UMLS:C0020474" ; oboInOwl:id "HP:0008158" ; a owl:Class ; rdfs:label "Hyperapobetalipoproteinemia" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_39026 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008160 obo:IAO_0000115 "The concentration of 2-hydroxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C4024725" ; oboInOwl:id "HP:0008160" ; a owl:Class ; rdfs:label "3-hydroxydicarboxylic aciduria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0008161 obo:IAO_0000115 "Alkaline phosphatase levels measured within leukocytes is below detectable levels." ; oboInOwl:hasDbXref "UMLS:C4024724" ; oboInOwl:hasExactSynonym "Absent leukocyte ALP" ; oboInOwl:id "HP:0008161" ; a owl:Class ; rdfs:label "Absent leukocyte alkaline phosphatase" ; rdfs:subClassOf obo:HP_0004852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008162 obo:IAO_0000115 "An increased concentration of ammonia in the blood not associated with symptoms such as encephalopathy." ; oboInOwl:hasDbXref "UMLS:C4021552" ; oboInOwl:hasExactSynonym "Hyperammonemia, asymptomatic" ; oboInOwl:id "HP:0008162" ; a owl:Class ; rdfs:label "Asymptomatic hyperammonemia" ; rdfs:subClassOf obo:HP_0001987 . obo:HP_0008163 obo:IAO_0000115 "Abnormally reduced concentration of cortisol in the blood." ; oboInOwl:hasAlternativeId "HP:0000874", "HP:0003291", "HP:0004317", "HP:0008220" ; oboInOwl:hasDbXref "UMLS:C1833054", "UMLS:C1836623", "UMLS:C1846225" ; oboInOwl:hasExactSynonym "Decreased cortisol production", "Glucocorticoid insufficiency", "Hypocortisolemia", "Low blood cortisol level", "Low to undetectable plasma cortisol", "Plasma cortisol low" ; oboInOwl:hasRelatedSynonym "Hypocortisolism" ; oboInOwl:id "HP:0008163" ; a owl:Class ; rdfs:label "Decreased circulating cortisol level" ; rdfs:subClassOf obo:HP_0008207, obo:HP_0011731 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17650 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008165 obo:IAO_0000115 "Reduced proportion of helper T cells relative to the total number of T cells." ; oboInOwl:hasDbXref "UMLS:C4024723" ; oboInOwl:hasExactSynonym "Decreased proportion circulating T-helper cells", "Reduced helper T cell proportion" ; oboInOwl:id "HP:0008165" ; a owl:Class ; rdfs:label "Decreased helper T cell proportion" ; rdfs:subClassOf obo:HP_0005403, obo:HP_0500263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008166 obo:IAO_0000115 "Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma." ; oboInOwl:hasAlternativeId "HP:0003644", "HP:0008300" ; oboInOwl:hasDbXref "MSH:D016537", "SNOMEDCT_US:238025006", "UMLS:C0085131", "UMLS:C1854788", "UMLS:C1856559" ; oboInOwl:hasExactSynonym "Beta-galactosidase deficiency in fibroblasts and white blood cells", "Beta-galactosidase-1 deficiency", "Decreased beta galactosidase activity" ; oboInOwl:id "HP:0008166" ; a owl:Class ; rdfs:label "Decreased beta-galactosidase activity" ; rdfs:subClassOf obo:HP_0004342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0004565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008167 oboInOwl:hasDbXref "UMLS:C3279397" ; oboInOwl:id "HP:0008167" ; a owl:Class ; rdfs:label "Very long chain fatty acid accumulation" ; rdfs:subClassOf obo:HP_0032243 . obo:HP_0008169 obo:IAO_0000115 "Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X." ; oboInOwl:hasDbXref "MSH:D005168", "SNOMEDCT_US:37193007", "UMLS:C0015503", "UMLS:C4024722" ; oboInOwl:hasRelatedSynonym "Factor VII deficiency" ; oboInOwl:id "HP:0008169" ; a owl:Class ; rdfs:label "Reduced factor VII activity" ; rdfs:subClassOf obo:HP_0010988 . obo:HP_0008176 oboInOwl:hasDbXref "SNOMEDCT_US:281611002", "UMLS:C0559506" ; oboInOwl:id "HP:0008176" ; a owl:Class ; rdfs:label "Neonatal unconjugated hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0002904 . obo:HP_0008178 oboInOwl:hasDbXref "UMLS:C4024721" ; oboInOwl:id "HP:0008178" ; a owl:Class ; rdfs:label "Abnormal cartilage matrix" ; rdfs:subClassOf obo:HP_0002763 . obo:HP_0008179 obo:IAO_0000115 "An abnormal reduction in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record." ; oboInOwl:hasDbXref "UMLS:C4024720" ; oboInOwl:hasExactSynonym "Decreased Arden ratio of EOG" ; oboInOwl:id "HP:0008179" ; a owl:Class ; rdfs:label "Decreased Arden ratio of electrooculogram" ; rdfs:subClassOf obo:HP_0030454 . obo:HP_0008180 oboInOwl:hasAlternativeId "HP:0003211" ; oboInOwl:hasDbXref "UMLS:C1850309" ; oboInOwl:hasExactSynonym "Mildly elevated CPK", "Mildly elevated creatine phosphokinase", "Mildly elevated serum CK", "Mildly elevated serum CPK", "Mildly elevated serum phospho-CK", "Mildly increased creatine kinase", "Mildly increased serum creatine kinase", "Moderately elevated serum CK", "Moderately elevated serum CPK", "Moderately increased serum creatine kinase" ; oboInOwl:id "HP:0008180" ; a owl:Class ; rdfs:comment """'has part' some ('increased amount' and ('inheres in' some blood) and (towards some IMR_0002602) and ('has modifier' some 'mild intensity') and ('has modifier' some abnormal))""" ; rdfs:label "Mildly elevated creatine kinase" ; rdfs:subClassOf obo:HP_0003236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008181 obo:IAO_0000115 "An absence of low-density lipoprotein cholesterol in the blood." ; oboInOwl:hasDbXref "MSH:D000012", "SNOMEDCT_US:190787008", "UMLS:C0000744" ; oboInOwl:id "HP:0008181" ; a owl:Class ; rdfs:comment "Beta-lipoprotein cholesterol is a synonym for low-density lipoprotein (LDL) cholesterol." ; rdfs:label "Abetalipoproteinemia" ; rdfs:subClassOf obo:HP_0003563 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_39026 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008182 oboInOwl:hasDbXref "UMLS:C4024719" ; oboInOwl:hasExactSynonym "Small adrenal cortex" ; oboInOwl:id "HP:0008182" ; a owl:Class ; rdfs:label "Adrenocortical hypoplasia" ; rdfs:subClassOf obo:HP_0000849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008185 obo:IAO_0000115 "The onset of puberty before the age of 9 years in boys." ; oboInOwl:hasDbXref "UMLS:C1859979" ; oboInOwl:hasExactSynonym "Early onset of puberty in males", "Male precocious puberty" ; oboInOwl:id "HP:0008185" ; a owl:Class ; rdfs:label "Precocious puberty in males" ; rdfs:subClassOf obo:HP_0000826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008186 obo:IAO_0000115 "The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex." ; oboInOwl:hasDbXref "UMLS:C1851720" ; oboInOwl:id "HP:0008186" ; a owl:Class ; rdfs:comment "This feature is common in Beckwith Wiedemann syndrome." ; rdfs:label "Adrenocortical cytomegaly" ; rdfs:subClassOf obo:HP_0011732 . obo:HP_0008187 obo:IAO_0000115 "No secondary sexual characteristics are present at puberty." ; oboInOwl:hasAlternativeId "HP:0008674" ; oboInOwl:hasDbXref "UMLS:C4021551" ; oboInOwl:hasExactSynonym "No secondary sexual characteristics at puberty" ; oboInOwl:id "HP:0008187" ; a owl:Class ; rdfs:label "Absence of secondary sex characteristics" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0008188 oboInOwl:hasDbXref "MSH:D050033", "UMLS:C1563716" ; oboInOwl:hasExactSynonym "Thyroid dysplasia" ; oboInOwl:id "HP:0008188" ; a owl:Class ; rdfs:label "Thyroid dysgenesis" ; rdfs:subClassOf obo:HP_0011772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008189 obo:IAO_0000115 "Decreased sensitivity toward insulin." ; oboInOwl:hasDbXref "UMLS:C1864570" ; oboInOwl:id "HP:0008189" ; a owl:Class ; rdfs:label "Insulin insensitivity" ; rdfs:subClassOf obo:HP_0011014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001550 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:PR_000009054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008191 obo:IAO_0000115 "The congenital absence of the thyroid gland." ; oboInOwl:hasDbXref "MSH:D050033", "UMLS:C0749420", "UMLS:C4020805" ; oboInOwl:hasRelatedSynonym "Athyroidal hypothyroidism" ; oboInOwl:id "HP:0008191" ; a owl:Class ; rdfs:label "Thyroid agenesis" ; rdfs:subClassOf obo:HP_0033079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008193 oboInOwl:hasDbXref "UMLS:C1859014" ; oboInOwl:id "HP:0008193" ; a owl:Class ; rdfs:label "Primary gonadal insufficiency" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0008194 obo:IAO_0000115 "The presence of multiple pancreatic islet cell adenomas." ; oboInOwl:hasDbXref "UMLS:C4024718" ; oboInOwl:id "HP:0008194" ; a owl:Class ; rdfs:label "Multiple pancreatic beta-cell adenomas" ; rdfs:subClassOf obo:HP_0008261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:MPATH_287 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002118 ] ) ] ] . obo:HP_0008197 oboInOwl:hasDbXref "UMLS:C1846228" ; oboInOwl:id "HP:0008197" ; a owl:Class ; rdfs:label "Absence of pubertal development" ; rdfs:subClassOf obo:HP_0008373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0045136 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008198 obo:IAO_0000115 "Deficiency of parathyroid hormone with congenital onset." ; oboInOwl:hasAlternativeId "HP:0008199", "HP:0008201" ; oboInOwl:hasDbXref "UMLS:C1455734" ; oboInOwl:hasExactSynonym "Neonatal hypoparathyroidism" ; oboInOwl:id "HP:0008198" ; a owl:Class ; rdfs:label "Congenital hypoparathyroidism" ; rdfs:subClassOf obo:HP_0000829 . obo:HP_0008200 obo:IAO_0000115 "A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia." ; oboInOwl:hasAlternativeId "HP:0008254" ; oboInOwl:hasDbXref "MSH:D049950", "SNOMEDCT_US:36348003", "UMLS:C0221002" ; oboInOwl:id "HP:0008200" ; a owl:Class ; rdfs:label "Primary hyperparathyroidism" ; rdfs:subClassOf obo:HP_0000843 . obo:HP_0008202 obo:IAO_0000115 "A reduced level of prolactin in the blood circulation. Prolactin is a protein hormone that is secreted by lactotrophs in the anterior pituitary and that stimulates mammary gland development and milk production." ; oboInOwl:hasDbXref "MSH:C562708", "SNOMEDCT_US:67873006", "UMLS:C0271586" ; oboInOwl:hasExactSynonym "Prolactin deficiency" ; oboInOwl:id "HP:0008202" ; a owl:Class ; rdfs:label "Reduced circulating prolactin concentration" ; rdfs:subClassOf obo:HP_0040086 . obo:HP_0008204 oboInOwl:hasDbXref "UMLS:C1868007" ; oboInOwl:hasExactSynonym "Precocious puberty with Sertoli cell tumour" ; oboInOwl:id "HP:0008204" ; a owl:Class ; rdfs:label "Precocious puberty with Sertoli cell tumor" ; rdfs:subClassOf obo:HP_0000826, obo:HP_0100619 . obo:HP_0008205 obo:IAO_0000115 "Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin." ; oboInOwl:hasDbXref "UMLS:C1842404" ; oboInOwl:id "HP:0008205" ; a owl:Class ; rdfs:label "Insulin-dependent but ketosis-resistant diabetes" ; rdfs:subClassOf obo:HP_0005978 . obo:HP_0008207 obo:IAO_0000115 "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves." ; oboInOwl:hasAlternativeId "HP:0000862", "HP:0008219", "HP:0008252" ; oboInOwl:hasDbXref "MSH:D000224", "SNOMEDCT_US:363732003", "SNOMEDCT_US:373662000", "SNOMEDCT_US:386584007", "UMLS:C0001403", "UMLS:C0405580" ; oboInOwl:hasExactSynonym "Adrenocortical insufficiency", "Primary adrenocortical failure" ; oboInOwl:hasRelatedSynonym "Addison disease", "Addison's disease" ; oboInOwl:id "HP:0008207" ; a owl:Class ; rdfs:comment "Deficiency of both glucocorticoids and mineralocorticoids." ; rdfs:label "Primary adrenal insufficiency" ; rdfs:subClassOf obo:HP_0000846 . obo:HP_0008208 obo:IAO_0000115 "Hyperplasia of the parathyroid gland." ; oboInOwl:hasDbXref "SNOMEDCT_US:9092004", "UMLS:C0271844" ; oboInOwl:hasExactSynonym "Enlarged parathyroid glands" ; oboInOwl:id "HP:0008208" ; a owl:Class ; rdfs:comment "An absolute increase in the mass of the parenchymal cells of the parathyroid gland leading to an enlargement of the parathyroid glands." ; rdfs:label "Parathyroid hyperplasia" ; rdfs:subClassOf obo:HP_0011766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008209 obo:IAO_0000115 "Amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian inssuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea." ; oboInOwl:hasAlternativeId "HP:0001587", "HP:0100805" ; oboInOwl:hasDbXref "MSH:D008594", "MSH:D016649", "SNOMEDCT_US:373717006", "UMLS:C0025322", "UMLS:C0085215" ; oboInOwl:hasExactSynonym "Climacterium praecox", "Early menopause", "Hypergonadotropic amenorrhea", "Menopause praecox", "Premature menopause", "Premature ovarian failure", "Primary ovarian insufficiency" ; oboInOwl:id "HP:0008209" ; a owl:Class ; rdfs:comment "The causes of primary ovarian insuficiency (POI) include chromosomal and genetic defects, autoimmune processes, chemotherapy, radiation, infections and surgery, but many are unidentified (idiopathic). The age of 40 is set by convention but is supported by clinical observations. From a statistical point of view, the age limit of 40 is approximately two standard deviations (SD) below the average age at natural menopause (50 plus/minus 4 years)." ; rdfs:label "Premature ovarian insufficiency" ; rdfs:subClassOf obo:HP_0031066 . obo:HP_0008211 obo:IAO_0000115 "Aplasia of the parathyroid gland." ; oboInOwl:hasDbXref "MSH:C563238", "SNOMEDCT_US:73291005", "UMLS:C1321907" ; oboInOwl:hasExactSynonym "Parathyroid absence", "Parathyroid aplasia" ; oboInOwl:id "HP:0008211" ; a owl:Class ; rdfs:label "Parathyroid agenesis" ; rdfs:subClassOf obo:HP_0011768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008213 obo:IAO_0000115 "A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH)." ; oboInOwl:hasAlternativeId "HP:0008192" ; oboInOwl:hasDbXref "MSH:D007006", "SNOMEDCT_US:33927004", "UMLS:C0271623" ; oboInOwl:hasExactSynonym "Pituitary gonadotropin deficiency" ; oboInOwl:id "HP:0008213" ; a owl:Class ; rdfs:label "Gonadotropin deficiency" ; rdfs:subClassOf obo:HP_0000830 . obo:HP_0008214 obo:IAO_0000115 "A reduction below normal concentration of estradiol in the circulation." ; oboInOwl:hasDbXref "SNOMEDCT_US:166449002", "UMLS:C0241011" ; oboInOwl:hasExactSynonym "Decreased serum estradiol" ; oboInOwl:id "HP:0008214" ; a owl:Class ; rdfs:label "Decreased serum estradiol" ; rdfs:subClassOf obo:HP_0025133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23965 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008216 obo:IAO_0000115 "Abnormal development of the adrenal gland." ; oboInOwl:hasDbXref "UMLS:C1856017" ; oboInOwl:hasExactSynonym "Adrenal gland dysplasia", "Dysplastic adrenal glands" ; oboInOwl:id "HP:0008216" ; a owl:Class ; rdfs:label "Adrenal gland dysgenesis" ; rdfs:subClassOf obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008221 obo:IAO_0000115 "Enlargement of the adrenal gland." ; oboInOwl:hasDbXref "SNOMEDCT_US:419920004", "UMLS:C1621895" ; oboInOwl:hasExactSynonym "Enlarged adrenal glands" ; oboInOwl:id "HP:0008221" ; a owl:Class ; rdfs:label "Adrenal hyperplasia" ; rdfs:subClassOf obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008222 oboInOwl:hasDbXref "MSH:D007247", "SNOMEDCT_US:6738008", "UMLS:C0021361" ; oboInOwl:hasExactSynonym "Female infertility" ; oboInOwl:id "HP:0008222" ; a owl:Class ; rdfs:label "Female infertility" ; rdfs:subClassOf obo:HP_0000789, obo:HP_0000868 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000892 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008223 obo:IAO_0000115 "Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4)." ; oboInOwl:hasDbXref "SNOMEDCT_US:237523006", "UMLS:C0342162" ; oboInOwl:hasExactSynonym "Mild hypothyroidism", "Subclinical hypothyroidism" ; oboInOwl:id "HP:0008223" ; a owl:Class ; rdfs:label "Compensated hypothyroidism" ; rdfs:subClassOf obo:HP_0000821 . obo:HP_0008225 oboInOwl:hasDbXref "UMLS:C1969546" ; oboInOwl:id "HP:0008225" ; a owl:Class ; rdfs:label "Thyroid follicular hyperplasia" ; rdfs:subClassOf obo:HP_0008249 . obo:HP_0008226 obo:IAO_0000115 "Insufficient amount of androgenic activity." ; oboInOwl:hasDbXref "SNOMEDCT_US:38825009", "UMLS:C0342527" ; oboInOwl:hasExactSynonym "Hypoandrogenism" ; oboInOwl:id "HP:0008226" ; a owl:Class ; rdfs:label "Androgen insufficiency" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0008227 obo:IAO_0000115 "A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal." ; oboInOwl:hasDbXref "SNOMEDCT_US:360348000", "SNOMEDCT_US:360353005", "UMLS:C0342198" ; oboInOwl:id "HP:0008227" ; a owl:Class ; rdfs:label "Pituitary resistance to thyroid hormone" ; rdfs:subClassOf obo:HP_0011747 . obo:HP_0008229 obo:IAO_0000115 "The presence of lymphangiectasis of the thyroid gland." ; oboInOwl:hasAlternativeId "HP:0008235" ; oboInOwl:hasDbXref "UMLS:C1856129" ; oboInOwl:hasExactSynonym "Thyroid lymphangiectasis" ; oboInOwl:id "HP:0008229" ; a owl:Class ; rdfs:comment "A stretching and widening of the lymphatic vessels of the thyroid gland." ; rdfs:label "Thyroid lymphangiectasia" ; rdfs:subClassOf obo:HP_0011772, obo:HP_0031842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_98 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008230 obo:IAO_0100001 "HP:0040171" ; dcterms:creator ; oboInOwl:id "HP:0008230" ; a owl:Class ; rdfs:label "obsolete Decreased testosterone in males" ; owl:deprecated true . obo:HP_0008231 oboInOwl:hasDbXref "SNOMEDCT_US:237778003", "UMLS:C0342495" ; oboInOwl:id "HP:0008231" ; a owl:Class ; rdfs:label "Macronodular adrenal hyperplasia" ; rdfs:subClassOf obo:HP_0008221 . obo:HP_0008232 obo:IAO_0000115 "An elevated concentration of follicle-stimulating hormone in the blood." ; oboInOwl:hasAlternativeId "HP:0008324" ; oboInOwl:hasDbXref "UMLS:C4021550" ; oboInOwl:hasExactSynonym "Elevated FSH level", "Elevated follicle stimulating hormone", "Elevated follicle-stimulating hormone", "Elevated plasma follicle stimulating hormone", "Increased circulating follicle stimulating hormone level" ; oboInOwl:id "HP:0008232" ; a owl:Class ; rdfs:label "Elevated circulating follicle stimulating hormone level" ; rdfs:subClassOf obo:HP_0000837, obo:HP_0030346 . obo:HP_0008233 obo:IAO_0000115 "An reduced concentration of progesterone in the blood." ; oboInOwl:hasDbXref "UMLS:C1858995" ; oboInOwl:hasExactSynonym "Decreased serum progesterone" ; oboInOwl:id "HP:0008233" ; a owl:Class ; rdfs:comment "Progesterone is a steroid hormone secreted by the corpus luteum after ovulation during the second half of the menstrual cycle." ; rdfs:label "Decreased circulating progesterone" ; rdfs:subClassOf obo:HP_0031212 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17026 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008236 oboInOwl:hasDbXref "SNOMEDCT_US:4294006", "UMLS:C0271528" ; oboInOwl:id "HP:0008236" ; a owl:Class ; rdfs:label "Isosexual precocious puberty" ; rdfs:subClassOf obo:HP_0000826 . obo:HP_0008237 obo:IAO_0000115 "A type of hypothyroidism that results from a defect in thyrotropin-releasing hormone activity." ; oboInOwl:hasDbXref "SNOMEDCT_US:37429009", "UMLS:C0220998" ; oboInOwl:hasExactSynonym "Tertiary hypothyroidism" ; oboInOwl:id "HP:0008237" ; a owl:Class ; rdfs:comment """The simultaneous occurrence a low thyroid hormone level and a normal or low serum level of thyroid stimulating hormone (TSH) in a patient with hypothyroidism establishes the diagnosis of secondary hypothyroidism. The administration of thyrotropin releasing hormone (TRH), which is normally synthesized and released by the hypothalamus, enables the physician to distinguish between pituitary and hypothalamic causes of hypothyroidism. TRH will normally cause the release of TSH from the pituitary gland. When the hypothalamus does not synthesize or release TRH, the administration of exogenous TRH will result in prompt rise of serum TSH. To date, the cases reported of pituitary hypothyroidism. Hypothalamic hypothyroidism, on the other hand, may either be idiopathic or result from demonstrable hypothalamic disease.""" ; rdfs:label "Hypothalamic hypothyroidism" ; rdfs:subClassOf obo:HP_0011787, obo:HP_0012285 . obo:HP_0008239 obo:IAO_0000115 "Developmental hypoplasia of the adrenal medulla." ; oboInOwl:hasDbXref "UMLS:C4024717" ; oboInOwl:hasExactSynonym "Small adrenal medulla" ; oboInOwl:id "HP:0008239" ; a owl:Class ; rdfs:label "Adrenal medullary hypoplasia" ; rdfs:subClassOf obo:HP_0000835 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008240 oboInOwl:hasDbXref "UMLS:C4024716" ; oboInOwl:id "HP:0008240" ; a owl:Class ; rdfs:label "Secondary growth hormone deficiency" ; rdfs:subClassOf obo:HP_0000824 . obo:HP_0008242 obo:IAO_0000115 "A state of renal tubular unresponsiveness or resistance to the action of aldosterone." ; oboInOwl:hasAlternativeId "HP:0008228" ; oboInOwl:hasDbXref "MSH:D011546", "SNOMEDCT_US:77098009", "UMLS:C0033805" ; oboInOwl:id "HP:0008242" ; a owl:Class ; rdfs:comment "Pseudohypoaldosteronism is characterized by hyperkalemia, metabolic acidosis, and normal glomerular filtration rate. This term refers to the phenotypic finding of pseudohypoaldosteronism rather than the disease of idiopathic pseudohypoaldosteronism." ; rdfs:label "Pseudohypoaldosteronism" ; rdfs:subClassOf obo:HP_0011733 . obo:HP_0008244 obo:IAO_0000115 "A type of adrenal hypoplasia with congenital onset." ; oboInOwl:hasAlternativeId "HP:0008246" ; oboInOwl:hasDbXref "SNOMEDCT_US:93235007", "UMLS:C0220766" ; oboInOwl:hasExactSynonym "Congenital adrenal gland hypoplasia" ; oboInOwl:id "HP:0008244" ; a owl:Class ; rdfs:label "Congenital adrenal hypoplasia" ; rdfs:subClassOf obo:HP_0000835 . obo:HP_0008245 obo:IAO_0000115 "A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion." ; oboInOwl:hasAlternativeId "HP:0008248" ; oboInOwl:hasDbXref "SNOMEDCT_US:82598004", "UMLS:C3665349" ; oboInOwl:hasExactSynonym "Low thyroid gland function due to abnormal pituitary gland", "Secondary hypothyroidism", "TSH deficient hypothyroidism", "Thyroid stimulating hormone deficiency", "Thyrotropin deficiency" ; oboInOwl:id "HP:0008245" ; a owl:Class ; rdfs:label "Pituitary hypothyroidism" ; rdfs:subClassOf obo:HP_0000830, obo:HP_0011787 . obo:HP_0008247 obo:IAO_0000115 "Increased levels of thyroxine without evidence of clinical thyroid disease." ; oboInOwl:hasAlternativeId "HP:0008212" ; oboInOwl:hasDbXref "UMLS:C4021549" ; oboInOwl:hasExactSynonym "Asymptomatic hyperthyroxinemia" ; oboInOwl:id "HP:0008247" ; a owl:Class ; rdfs:comment "Any functional abnormality of the thyroid gland and the systems that control its rate of production of thyroid hormone (hypothalamic-pituitary-thyroid axis) and the peripheral reactivity to thyroid hormone." ; rdfs:label "Euthyroid hyperthyroxinemia" ; rdfs:subClassOf obo:HP_0002926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008249 obo:IAO_0000115 "Hyperplasia of the thyroid gland." ; oboInOwl:hasDbXref "UMLS:C1112776" ; oboInOwl:hasExactSynonym "Large thyroid" ; oboInOwl:id "HP:0008249" ; a owl:Class ; rdfs:label "Thyroid hyperplasia" ; rdfs:subClassOf obo:HP_0011772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008250 obo:IAO_0100001 "HP:0003072" ; oboInOwl:id "HP:0008250" ; a owl:Class ; rdfs:label "obsolete Infantile hypercalcemia" ; owl:deprecated true . obo:HP_0008251 obo:IAO_0000115 "An enlargement of the thyroid gland with congenital onset." ; oboInOwl:hasDbXref "SNOMEDCT_US:276565004", "UMLS:C0349476" ; oboInOwl:hasExactSynonym "Congenital goitre" ; oboInOwl:id "HP:0008251" ; a owl:Class ; rdfs:label "Congenital goiter" ; rdfs:subClassOf obo:HP_0000853 . obo:HP_0008255 oboInOwl:hasDbXref "SNOMEDCT_US:237603002", "UMLS:C0342273" ; oboInOwl:id "HP:0008255" ; a owl:Class ; rdfs:label "Transient neonatal diabetes mellitus" ; rdfs:subClassOf obo:HP_0000857 . obo:HP_0008256 obo:IAO_0000115 "Adrenocortical adenomas are benign tumors of the adrenal cortex." ; oboInOwl:hasAlternativeId "HP:0008196" ; oboInOwl:hasDbXref "MSH:D018246", "SNOMEDCT_US:18365006", "SNOMEDCT_US:255036008", "SNOMEDCT_US:302826002", "UMLS:C0206667" ; oboInOwl:hasExactSynonym "Adrenocortical adenomas" ; oboInOwl:id "HP:0008256" ; a owl:Class ; rdfs:label "Adrenocortical adenoma" ; rdfs:subClassOf obo:HP_0100641 . obo:HP_0008258 obo:IAO_0000115 "A type of adrenal hyperplasia with congenital onset." ; oboInOwl:hasDbXref "MSH:D000312", "SNOMEDCT_US:237751000", "UMLS:C0001627" ; oboInOwl:id "HP:0008258" ; a owl:Class ; rdfs:label "Congenital adrenal hyperplasia" ; rdfs:subClassOf obo:HP_0008221 . obo:HP_0008259 obo:IAO_0000115 "Adrenal insufficiency secondary to a defect in the ACTH receptor." ; oboInOwl:hasDbXref "UMLS:C4021548" ; oboInOwl:hasExactSynonym "ACTH receptor defect", "ACTHR defect", "Adrenocorticotropic hormone-resistant adrenal insufficiency" ; oboInOwl:id "HP:0008259" ; a owl:Class ; rdfs:label "Adrenocorticotropin receptor defect" ; rdfs:subClassOf obo:HP_0011734 . obo:HP_0008261 obo:IAO_0000115 "The presence of an adenoma of the pancreas with origin in a pancreatic B cell." ; oboInOwl:hasDbXref "UMLS:C1851697" ; oboInOwl:id "HP:0008261" ; a owl:Class ; rdfs:label "Pancreatic islet cell adenoma" ; rdfs:subClassOf obo:HP_0002894, obo:HP_0006476, obo:HP_0030405 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_287 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008263 oboInOwl:hasDbXref "UMLS:C1848800" ; oboInOwl:id "HP:0008263" ; a owl:Class ; rdfs:label "Thyroid defect in oxidation and organification of iodide" ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0008264 obo:IAO_0000115 "The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies." ; oboInOwl:hasAlternativeId "HP:0001932" ; oboInOwl:hasDbXref "UMLS:C4021547" ; oboInOwl:id "HP:0008264" ; a owl:Class ; rdfs:label "Neutrophil inclusion bodies" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0008265 oboInOwl:hasDbXref "UMLS:C4024715" ; oboInOwl:id "HP:0008265" ; a owl:Class ; rdfs:label "Mitochondrial lysine transport defect" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0008269 oboInOwl:hasDbXref "UMLS:C3806125" ; oboInOwl:id "HP:0008269" ; a owl:Class ; rdfs:label "Increased red cell hemolysis by shear stress" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0008271 obo:IAO_0000115 "Abnormal morphology of collagen fibers in cartilage. In cartilage, collagen II, actually a collagen II:IX:XI heterofibril, is by far the most important type of collagen. A number of abnormalities may be appreciated by electron micrography or biochemical investigations, including sparse collagen fibers in the cartilage matrix." ; oboInOwl:hasDbXref "UMLS:C4020803", "UMLS:C4020804", "UMLS:C4021847" ; oboInOwl:hasRelatedSynonym "Abnormal hyaline collagen", "Abnormal type II collagen" ; oboInOwl:id "HP:0008271" ; a owl:Class ; rdfs:label "Abnormal cartilage collagen" ; rdfs:subClassOf obo:HP_0002763 . obo:HP_0008272 oboInOwl:hasDbXref "UMLS:C4024714" ; oboInOwl:id "HP:0008272" ; a owl:Class ; rdfs:label "Renal tubular lysine transport defect" ; rdfs:subClassOf obo:HP_0000124 . obo:HP_0008273 oboInOwl:hasDbXref "UMLS:C4024713" ; oboInOwl:id "HP:0008273" ; a owl:Class ; rdfs:label "Transient aminoaciduria" ; rdfs:subClassOf obo:HP_0003355 . obo:HP_0008275 oboInOwl:hasDbXref "UMLS:C4024712" ; oboInOwl:hasExactSynonym "Abnormal cone-mediated electroretinogram" ; oboInOwl:id "HP:0008275" ; a owl:Class ; rdfs:label "Abnormal light-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0030466 . obo:HP_0008277 obo:IAO_0000115 "An abnormality of zinc ion homeostasis." ; oboInOwl:hasDbXref "UMLS:C4020802", "UMLS:C4024711" ; oboInOwl:hasExactSynonym "Abnormality of zinc homeostasis" ; oboInOwl:hasRelatedSynonym "Abnormal zinc metabolism" ; oboInOwl:id "HP:0008277" ; a owl:Class ; rdfs:label "Abnormal blood zinc concentration" ; rdfs:subClassOf obo:HP_0011030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055069 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008278 obo:IAO_0000115 "Atrophy (wasting) of the cerebellar cortex." ; oboInOwl:hasDbXref "UMLS:C4024710" ; oboInOwl:hasExactSynonym "Cerebellar cortex degeneration" ; oboInOwl:id "HP:0008278" ; a owl:Class ; rdfs:comment "Cerebellar cortical atrophy may be associated with vacuolated or binucleated Purkinje cells." ; rdfs:label "Cerebellar cortical atrophy" ; rdfs:subClassOf obo:HP_0001272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008279 oboInOwl:hasDbXref "UMLS:C1850722" ; oboInOwl:id "HP:0008279" ; a owl:Class ; rdfs:label "Transient hyperlipidemia" ; rdfs:subClassOf obo:HP_0003077 . obo:HP_0008281 obo:IAO_0000115 "An increased concentration of ammonia in the blood with sudden onset." ; oboInOwl:hasDbXref "UMLS:C1859506" ; oboInOwl:hasExactSynonym "Hyperammonemia, acute" ; oboInOwl:id "HP:0008281" ; a owl:Class ; rdfs:label "Acute hyperammonemia" ; rdfs:subClassOf obo:HP_0001987 . obo:HP_0008282 obo:IAO_0000115 "An increased amount of unconjugated (indirect) bilurubin in the blood." ; oboInOwl:hasAlternativeId "HP:0008289" ; oboInOwl:hasDbXref "SNOMEDCT_US:7752002", "UMLS:C0268306" ; oboInOwl:id "HP:0008282" ; a owl:Class ; rdfs:label "Unconjugated hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0002904 . obo:HP_0008283 obo:IAO_0000115 "An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake." ; oboInOwl:hasDbXref "UMLS:C1864954" ; oboInOwl:hasExactSynonym "High blood insulin levels while fasting" ; oboInOwl:id "HP:0008283" ; a owl:Class ; rdfs:label "Fasting hyperinsulinemia" ; rdfs:subClassOf obo:HP_0000842 . obo:HP_0008285 oboInOwl:hasDbXref "UMLS:C4024709" ; oboInOwl:id "HP:0008285" ; a owl:Class ; rdfs:label "Transient hypophosphatemia" ; rdfs:subClassOf obo:HP_0002148 . obo:HP_0008288 oboInOwl:hasDbXref "MSH:D020158", "SNOMEDCT_US:237939006", "UMLS:C0751748" ; oboInOwl:id "HP:0008288" ; a owl:Class ; rdfs:label "Nonketotic hyperglycinemia" ; rdfs:subClassOf obo:HP_0002154 . obo:HP_0008290 obo:IAO_0000115 "A partial reduction in level of the complement component Factor H in circulation." ; oboInOwl:hasDbXref "UMLS:C4024708" ; oboInOwl:id "HP:0008290" ; a owl:Class ; rdfs:label "Partial complement factor H deficiency" ; rdfs:subClassOf obo:HP_0005369 . obo:HP_0008291 obo:IAO_0000115 "A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH)." ; oboInOwl:hasDbXref "MSH:D049913", "SNOMEDCT_US:21109002", "SNOMEDCT_US:254958004", "UMLS:C1306214" ; oboInOwl:hasExactSynonym "ACTH-producing pituitary adenoma", "Corticotropin-secreting pituitary adenoma" ; oboInOwl:id "HP:0008291" ; a owl:Class ; rdfs:label "Pituitary corticotropic cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0008293 obo:IAO_0000115 "An increase in the level of long-chain dicarboxylic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C1837273" ; oboInOwl:id "HP:0008293" ; a owl:Class ; rdfs:label "Long-chain dicarboxylic aciduria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0008297 obo:IAO_0000115 "A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine)." ; oboInOwl:hasDbXref "SNOMEDCT_US:28575006", "UMLS:C0268464" ; oboInOwl:id "HP:0008297" ; a owl:Class ; rdfs:label "Transient hyperphenylalaninemia" ; rdfs:subClassOf obo:HP_0010893 . obo:HP_0008301 obo:IAO_0000115 "An increased concentration of dermatan sulfate in the urine." ; oboInOwl:hasDbXref "UMLS:C1854774" ; oboInOwl:hasExactSynonym "Dermatan sulphate excretion in urine" ; oboInOwl:id "HP:0008301" ; a owl:Class ; rdfs:comment "Dermatan sulfate is a a glycosaminoglycan (mucopolysaccharide) found in skin, blood vessels, heart valves, tendons, and lungs." ; rdfs:label "Dermatan sulfate excretion in urine" ; rdfs:subClassOf obo:HP_0008155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008303 obo:IAO_0000115 "Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata." ; oboInOwl:hasDbXref "UMLS:C4024707" ; oboInOwl:id "HP:0008303" ; a owl:Class ; rdfs:label "Olivary degeneration" ; rdfs:subClassOf obo:HP_0011441 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008305 obo:IAO_0000115 "Presence of myoglobin in the urine following exercise." ; oboInOwl:hasAlternativeId "HP:0008319" ; oboInOwl:hasDbXref "UMLS:C1845155", "UMLS:C1860069" ; oboInOwl:hasRelatedSynonym "Exercise-induced myoglobinuria in adults" ; oboInOwl:id "HP:0008305" ; a owl:Class ; rdfs:label "Exercise-induced myoglobinuria" ; rdfs:subClassOf obo:HP_0002913 . obo:HP_0008306 oboInOwl:hasDbXref "UMLS:C3151556" ; oboInOwl:id "HP:0008306" ; a owl:Class ; rdfs:label "Abnormal iron deposition in mitochondria" ; rdfs:subClassOf obo:HP_0003287 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:GO_0005739 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008309 obo:IAO_0000115 "An increase in the level of medium chain dicarboxylic acid in the urine." ; oboInOwl:hasDbXref "UMLS:C1860081" ; oboInOwl:id "HP:0008309" ; a owl:Class ; rdfs:label "Medium chain dicarboxylic aciduria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0008311 oboInOwl:hasDbXref "UMLS:C4024706" ; oboInOwl:id "HP:0008311" ; a owl:Class ; rdfs:label "Spinal cord posterior columns myelin loss" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0007305 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0032286 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008314 obo:IAO_0000115 "A reduction in the activity of the mitochondrial respiratory chain complex II, which is part of the electron transport chain in mitochondria." ; oboInOwl:hasDbXref "UMLS:C4020801", "UMLS:C4024705" ; oboInOwl:hasRelatedSynonym "Respiratory complex II deficiency" ; oboInOwl:id "HP:0008314" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial complex II" ; rdfs:subClassOf obo:HP_0008972 . obo:HP_0008315 obo:IAO_0000115 "A decreased concentration of free (unbound) carnitine in the blood." ; oboInOwl:hasDbXref "UMLS:C4015009" ; oboInOwl:id "HP:0008315" ; a owl:Class ; rdfs:label "Decreased plasma free carnitine" ; rdfs:subClassOf obo:HP_0003234 . obo:HP_0008316 obo:IAO_0000115 "An abnormality of the mitochondria in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C4021546" ; oboInOwl:hasExactSynonym "Abnormal mitochondria in muscle" ; oboInOwl:id "HP:0008316" ; a owl:Class ; rdfs:comment "This finding is typically demonstrated by muscle biopsy." ; rdfs:label "Abnormal mitochondria in muscle tissue" ; rdfs:subClassOf obo:HP_0003287, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0005739 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008318 obo:IAO_0000115 "Increased alkaline phosphatase measured within leukocytes." ; oboInOwl:hasDbXref "UMLS:C4024704" ; oboInOwl:hasExactSynonym "Elevated leukocyte ALP" ; oboInOwl:id "HP:0008318" ; a owl:Class ; rdfs:label "Elevated leukocyte alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008320 obo:IAO_0000115 "Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics." ; oboInOwl:hasDbXref "UMLS:C4024703" ; oboInOwl:id "HP:0008320" ; a owl:Class ; rdfs:label "Impaired collagen-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0008321 obo:IAO_0000115 "Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa)." ; oboInOwl:hasDbXref "MSH:D005171", "SNOMEDCT_US:76642003", "UMLS:C0015519", "UMLS:C4024702" ; oboInOwl:hasExactSynonym "Decreased factor x activity" ; oboInOwl:hasRelatedSynonym "Factor X deficiency" ; oboInOwl:id "HP:0008321" ; a owl:Class ; rdfs:label "Reduced factor X activity" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0008322 obo:IAO_0000115 "Any structural anomaly of the mitochondria." ; oboInOwl:hasDbXref "UMLS:C4014650" ; oboInOwl:hasExactSynonym "Abnormal mitochondrion morphology" ; oboInOwl:id "HP:0008322" ; a owl:Class ; rdfs:comment "This feature may be assessed by means of electron microscopy." ; rdfs:label "Abnormal mitochondrial morphology" ; rdfs:subClassOf obo:HP_0012103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008323 obo:IAO_0000115 "An abnormality of the combined rod-and-cone response on electroretinogram." ; oboInOwl:hasDbXref "UMLS:C3151111" ; oboInOwl:hasExactSynonym "Abnormal rod and cone electroretinogram" ; oboInOwl:id "HP:0008323" ; a owl:Class ; rdfs:comment "The dark-adapted 3.0 ERG can be used to elicit a combined rod-cone response." ; rdfs:label "Abnormal light- and dark-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0030466 . obo:HP_0008326 obo:IAO_0000115 "An abnormally decreased concentration of vitamin B6 in the blood circulation." ; oboInOwl:hasDbXref "MSH:D026681", "SNOMEDCT_US:386080007", "UMLS:C0936215" ; oboInOwl:hasExactSynonym "Reduced vitamin b6 levels", "Vitamin B6 deficiency" ; oboInOwl:id "HP:0008326" ; a owl:Class ; rdfs:label "Reduced circulating vitamin B6 level" ; rdfs:subClassOf obo:HP_0032476 . obo:HP_0008327 obo:IAO_0000115 "The presence of microscopic crystalline calcium precipitates in the form of oxalate and/or phosphate in the renal parenchyma." ; oboInOwl:hasDbXref "SNOMEDCT_US:236444003", "UMLS:C0403474" ; oboInOwl:id "HP:0008327" ; a owl:Class ; rdfs:comment "The qualifier microscopic is used to indicate that the nephrocalcinosis cannot be observed on visual or radiologic examination without further magnification (as can macroscopic nephrocalcinosis)." ; rdfs:label "Microscopic nephrocalcinosis" ; rdfs:subClassOf obo:HP_0000121 . obo:HP_0008330 obo:IAO_0000115 "Decreased activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces." ; oboInOwl:hasDbXref "UMLS:C4024701" ; oboInOwl:hasExactSynonym "Decreased von willebrand factor activity" ; oboInOwl:id "HP:0008330" ; a owl:Class ; rdfs:comment "Von Willebrand factor (VWF) is a key hemostatic protein, but documenting its function through laboratory tests is not always straightforward. VWF serves as a carrier protein for factor VIII (FVIII), and also facilitates platelet adhesion through its interaction with platelet GPIb on the platelet surface and through its binding to the subendothelial matrix. This interaction is driven in vivo by shear stress, which induces a conformational change in VWF that allows it to bind platelet GPIb. In vitro, however, this interaction is induced by the antibiotic ristocetin, which enables VWF and platelet GPIb to interact in the absence of shear forces. Laboratory testing of VWF utilizes ristocetin in the VWF ristocetin cofactor activity assay (VWF:RCo), which is a measure of VWF binding to platelets, or by ristocetin-induced platelet aggregation (RIPA)." ; rdfs:label "Reduced von Willebrand factor activity" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0008331 oboInOwl:hasDbXref "UMLS:C4024700" ; oboInOwl:hasExactSynonym "Elevated CK after exercise", "Elevated CPK after exercise", "Elevated creatine phosphokinase after exercise", "Elevated phospho-CK after exercise", "Elevated phospho-creatine kinase after exercise", "Increased CK after exercise", "Increased creatine kinase after exercise", "Increased creatine phosphokinase after exercise", "Increased phospho-CK after exercise", "Increased phospho-creatine kinase after exercise" ; oboInOwl:id "HP:0008331" ; a owl:Class ; rdfs:label "Elevated creatine kinase after exercise" ; rdfs:subClassOf obo:HP_0003236 . obo:HP_0008335 obo:IAO_0100001 "HP:0003355" ; oboInOwl:hasDbXref "MSH:D000608", "UMLS:C0002534" ; oboInOwl:id "HP:0008335" ; a owl:Class ; rdfs:label "obsolete Renal aminoaciduria" ; owl:deprecated true . obo:HP_0008336 oboInOwl:hasDbXref "UMLS:C3151953" ; oboInOwl:id "HP:0008336" ; a owl:Class ; rdfs:label "Complex organic aciduria" ; rdfs:subClassOf obo:HP_0001992 . obo:HP_0008338 obo:IAO_0000115 "A partial reduction in level of the complement component Factor D in circulation." ; oboInOwl:hasDbXref "UMLS:C4024699" ; oboInOwl:hasExactSynonym "Partial functional adipsin deficiency", "Partial functional factor d deficiency" ; oboInOwl:id "HP:0008338" ; a owl:Class ; rdfs:label "Partial functional complement factor D deficiency" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0008339 obo:IAO_0000115 "An increased urine level of any amino acid carrying two amino groups (Asparagine, glutamine and lysine, cystine, ornithine)." ; oboInOwl:hasDbXref "UMLS:C4024698" ; oboInOwl:id "HP:0008339" ; a owl:Class ; rdfs:label "Diaminoaciduria" ; rdfs:subClassOf obo:HP_0033100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_35987 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008341 obo:IAO_0000115 "A type of renal tubular acidosis characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. The urine cannot be acidified below a pH of 5.3, associated with acidemia and hypokalemia." ; oboInOwl:hasDbXref "MSH:D000141", "SNOMEDCT_US:236461000", "SNOMEDCT_US:86210009", "UMLS:C1704380" ; oboInOwl:hasExactSynonym "Renal tubular acidosis, type I" ; oboInOwl:id "HP:0008341" ; a owl:Class ; rdfs:label "Distal renal tubular acidosis" ; rdfs:subClassOf obo:HP_0001947 . obo:HP_0008344 obo:IAO_0000115 "Concentration of a branched chain amino acid in the blood above the upper limit of normal." ; oboInOwl:hasDbXref "UMLS:C4024697" ; oboInOwl:id "HP:0008344" ; a owl:Class ; rdfs:label "Elevated circulating branched chain amino acid concentration" ; rdfs:subClassOf obo:HP_0010892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008345 obo:IAO_0000115 "Underdevelopment of the dilatator pupillae." ; oboInOwl:hasDbXref "UMLS:C4024696" ; oboInOwl:hasExactSynonym "Hypoplasia of the pupil dilator muscle", "Underdeveloped iris dilator muscle", "Underdeveloped pupil dilator muscle" ; oboInOwl:id "HP:0008345" ; a owl:Class ; rdfs:label "Hypoplasia of the iris dilator muscle" ; rdfs:subClassOf obo:HP_0007676 . obo:HP_0008346 oboInOwl:hasDbXref "UMLS:C4024695" ; oboInOwl:hasExactSynonym "Increased sickling of erythrocytes", "Increased sickling of red cells" ; oboInOwl:id "HP:0008346" ; a owl:Class ; rdfs:label "Increased red cell sickling tendency" ; rdfs:subClassOf obo:HP_0011895 . obo:HP_0008347 obo:IAO_0000115 "A reduction in the activity of the mitochondrial respiratory chain complex IV, which is part of the electron transport chain in mitochondria." ; oboInOwl:hasDbXref "UMLS:C4020800" ; oboInOwl:hasRelatedSynonym "Respiratory complex IV deficiency" ; oboInOwl:id "HP:0008347" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial complex IV" ; rdfs:subClassOf obo:HP_0008972 . obo:HP_0008348 obo:IAO_0000115 "A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation." ; oboInOwl:hasAlternativeId "HP:0008310" ; oboInOwl:hasDbXref "UMLS:C4021545" ; oboInOwl:hasExactSynonym "Decreased IgG2 level in blood", "Immunoglobulin IgG2 deficiency", "Reduced IgG2 levels" ; oboInOwl:id "HP:0008348" ; a owl:Class ; rdfs:label "Decreased circulating IgG2 level" ; rdfs:subClassOf obo:HP_0032135 . obo:HP_0008352 obo:IAO_0000115 "An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation." ; oboInOwl:hasDbXref "UMLS:C4024694" ; oboInOwl:hasExactSynonym "Impaired thrombocytes adhesion" ; oboInOwl:id "HP:0008352" ; a owl:Class ; rdfs:label "Impaired platelet adhesion" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0008353 obo:IAO_0000115 "The presence of an abnormally increased concentration of neutral amino acids in the urine. The neutral amino acids are tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine." ; oboInOwl:hasDbXref "UMLS:C1856194" ; oboInOwl:id "HP:0008353" ; a owl:Class ; rdfs:label "Neutral hyperaminoaciduria" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0008354 obo:IAO_0000115 "Reduced ability to transform factor X into its activated form factor Xa." ; oboInOwl:hasDbXref "UMLS:C4024693" ; oboInOwl:id "HP:0008354" ; a owl:Class ; rdfs:label "Factor X activation deficiency" ; rdfs:subClassOf obo:HP_0008321 . obo:HP_0008356 oboInOwl:consider "HP:0003077" ; oboInOwl:id "HP:0008356" ; a owl:Class ; rdfs:label "obsolete Combined hyperlipidemia" ; owl:deprecated true . obo:HP_0008357 obo:IAO_0000115 "Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot." ; oboInOwl:hasDbXref "UMLS:C4024692" ; oboInOwl:id "HP:0008357" ; a owl:Class ; rdfs:label "Reduced factor XIII activity" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0008358 obo:IAO_0000115 "An increased concentration of proline in the blood." ; oboInOwl:hasDbXref "SNOMEDCT_US:59655002", "UMLS:C0268528" ; oboInOwl:hasExactSynonym "Prolinemia" ; oboInOwl:id "HP:0008358" ; a owl:Class ; rdfs:label "Hyperprolinemia" ; rdfs:subClassOf obo:HP_0010907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26271 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008360 obo:IAO_0000115 "A neonatal decreased concentration of proteins in the blood." ; oboInOwl:hasDbXref "UMLS:C4024691" ; oboInOwl:id "HP:0008360" ; a owl:Class ; rdfs:label "Neonatal hypoproteinemia" ; rdfs:subClassOf obo:HP_0003075 . obo:HP_0008361 oboInOwl:hasDbXref "UMLS:C4024690" ; oboInOwl:id "HP:0008361" ; a owl:Class ; rdfs:label "Corticospinal tract pallor" ; rdfs:subClassOf obo:HP_0002492 . obo:HP_0008362 obo:IAO_0000115 "Absence or underdevelopment of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:33:00Z" ; oboInOwl:hasAlternativeId "HP:0004694", "HP:0008118", "HP:0008126" ; oboInOwl:hasDbXref "UMLS:C1836213" ; oboInOwl:hasExactSynonym "Absent/small big toe", "Absent/underdeveloped big toe", "Aplastic/hypoplastic halluces" ; oboInOwl:id "HP:0008362" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the hallux" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008363 obo:IAO_0000115 "Absence or underdevelopment of the tarsal bones." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:35:00Z" ; oboInOwl:hasAlternativeId "HP:0008109" ; oboInOwl:hasDbXref "UMLS:C1848671" ; oboInOwl:hasExactSynonym "Absent/small ankle bone", "Absent/underdeveloped ankle bone", "Aplastic/hypoplastic tarsals" ; oboInOwl:id "HP:0008363" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the tarsal bones" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0006494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008364 obo:IAO_0000115 "An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:38:00Z" ; oboInOwl:hasDbXref "UMLS:C4024689" ; oboInOwl:hasExactSynonym "Abnormal heel bone" ; oboInOwl:id "HP:0008364" ; a owl:Class ; rdfs:label "Abnormality of the calcaneus" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008365 obo:IAO_0000115 "An abnormality of the talus." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:43:00Z" ; oboInOwl:hasDbXref "UMLS:C4024688" ; oboInOwl:hasExactSynonym "Abnormal large bone of ankle" ; oboInOwl:id "HP:0008365" ; a owl:Class ; rdfs:label "Abnormal talus morphology" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008366 obo:IAO_0000115 "Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:44:00Z" ; oboInOwl:hasAlternativeId "HP:0100492" ; oboInOwl:hasDbXref "SNOMEDCT_US:239742004", "UMLS:C0343149" ; oboInOwl:hasExactSynonym "Contractures involving the joints of the feet", "Contractures of the foot joints", "Joint contractures involving the joints of the feet" ; oboInOwl:id "HP:0008366" ; a owl:Class ; rdfs:label "Foot joint contracture" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0005750 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001487 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008368 obo:IAO_0000115 "Synostosis (bony fusion) involving one or more bones of the tarsus (calcaneus, talus, cuboid, navicular, cuneiiform bones)." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:52:00Z" ; oboInOwl:hasAlternativeId "HP:0001851", "HP:0001957", "HP:0008092", "HP:0100330" ; oboInOwl:hasDbXref "MSH:D000070604", "SNOMEDCT_US:27173008", "UMLS:C0265654" ; oboInOwl:hasExactSynonym "Fused ankle bones", "Synostosis involving tarsal bones", "Synostosis of tarsal bones", "Tarsal bone fusion", "Tarsal bone synostosis", "Tarsal fusion", "Tarsal fusions" ; oboInOwl:id "HP:0008368" ; a owl:Class ; rdfs:label "Tarsal synostosis" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0009140, obo:HP_0100266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008369 obo:IAO_0000115 "An abnormality of the formation and mineralization of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:53:00Z" ; oboInOwl:hasDbXref "UMLS:C4021544", "UMLS:C4025075" ; oboInOwl:hasExactSynonym "Abnormal ossification of tarsal bones", "Hardening of ankle bones" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of ankle bones" ; oboInOwl:id "HP:0008369" ; a owl:Class ; rdfs:label "Abnormal tarsal ossification" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0010675 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008371 obo:IAO_0000115 "Any abnormal process of ossification of the metatarsal bones, which normally are each ossified from two centers: one for the body, and one for the head (metatarsal II,III,IV, and V) and one for the body and one for the base (metatarsal I). The ossification process begins in the center of the body about the ninth week, and extends toward either extremity. The center for the base of the first metatarsal appears about the third year, and the centers for the heads of the other bones between the fifth and eighth years. They join the bodies between the eighteenth and twentieth years." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T11:59:00Z" ; oboInOwl:hasDbXref "UMLS:C4021543" ; oboInOwl:hasExactSynonym "Abnormal ossification involving metatarsal bones" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of long bone of foot" ; oboInOwl:id "HP:0008371" ; a owl:Class ; rdfs:label "Abnormal metatarsal ossification" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0010675 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001448 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008372 dcterms:creator ; oboInOwl:creation_date "2008-04-04T12:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4024686" ; oboInOwl:id "HP:0008372" ; a owl:Class ; rdfs:label "Abnormality of vitamin A metabolism" ; rdfs:subClassOf obo:HP_0100508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008373 dcterms:creator ; oboInOwl:creation_date "2008-04-04T12:35:00Z" ; oboInOwl:hasAlternativeId "HP:0000827" ; oboInOwl:hasDbXref "UMLS:C4024685" ; oboInOwl:hasExactSynonym "Puberty and gonadal disorders" ; oboInOwl:id "HP:0008373" ; a owl:Class ; rdfs:label "Puberty and gonadal disorders" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0008376 oboInOwl:hasDbXref "UMLS:C1834664" ; oboInOwl:hasExactSynonym "Breathy speech" ; oboInOwl:id "HP:0008376" ; a owl:Class ; rdfs:label "Nasal, dysarthic speech" ; rdfs:subClassOf obo:HP_0001260 . obo:HP_0008383 obo:IAO_0000115 "Nails whose growth is slower than normal." ; oboInOwl:hasAlternativeId "HP:0008411" ; oboInOwl:hasDbXref "UMLS:C1835238" ; oboInOwl:hasExactSynonym "Slow-growing nails" ; oboInOwl:id "HP:0008383" ; a owl:Class ; rdfs:label "Slow-growing nails" ; rdfs:subClassOf obo:HP_0030807 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035878 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001705 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008386 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the nail." ; oboInOwl:hasAlternativeId "HP:0008385" ; oboInOwl:hasDbXref "UMLS:C1859077" ; oboInOwl:hasExactSynonym "Absent/hypoplastic nails", "Absent/small nails", "Absent/underdeveloped nails", "Nail aplasia/hypoplasia" ; oboInOwl:id "HP:0008386" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the nails" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008388 obo:IAO_0000115 "An anomaly of the toenail." ; oboInOwl:hasDbXref "SNOMEDCT_US:700189007", "UMLS:C3839753" ; oboInOwl:hasExactSynonym "Abnormality of the toenail", "Abnormality of the toenails" ; oboInOwl:id "HP:0008388" ; a owl:Class ; rdfs:label "Abnormal toenail morphology" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008390 obo:IAO_0000115 "Repeated loss, or shedding, of the nails of the fingers and toes." ; oboInOwl:hasDbXref "UMLS:C4021542" ; oboInOwl:hasExactSynonym "Recurrent loss of toenails and fingernails", "Recurrent shedding of toenails and fingernails" ; oboInOwl:id "HP:0008390" ; a owl:Class ; rdfs:label "Recurrent loss of toenails and fingernails" ; rdfs:subClassOf obo:HP_0001806 . obo:HP_0008391 obo:IAO_0000115 "The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate." ; oboInOwl:hasDbXref "UMLS:C3551426" ; oboInOwl:hasExactSynonym "Poor fingernail formation" ; oboInOwl:id "HP:0008391" ; a owl:Class ; rdfs:label "Dystrophic fingernails" ; rdfs:subClassOf obo:HP_0001231, obo:HP_0008404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008392 obo:IAO_0000115 "A thickening of the stratum corneum in the region beneath the nails." ; oboInOwl:hasDbXref "SNOMEDCT_US:10165000", "UMLS:C0038605" ; oboInOwl:hasExactSynonym "Thickened, discolored skin under nail", "Thickened, discoloured skin under nail" ; oboInOwl:id "HP:0008392" ; a owl:Class ; rdfs:label "Subungual hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0009723 . obo:HP_0008393 oboInOwl:hasDbXref "UMLS:C4024684" ; oboInOwl:id "HP:0008393" ; a owl:Class ; rdfs:label "Congenital curved nail of fourth toe" ; rdfs:subClassOf obo:HP_0008388 . obo:HP_0008394 oboInOwl:hasBroadSynonym "Congenital malformed nails" ; oboInOwl:hasDbXref "UMLS:C1393669", "UMLS:C4280413" ; oboInOwl:id "HP:0008394" ; a owl:Class ; rdfs:label "Congenital onychodystrophy" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0008396 obo:IAO_0000115 "Chronic infection of the nails by Candida species." ; oboInOwl:hasDbXref "UMLS:C4024683" ; oboInOwl:id "HP:0008396" ; a owl:Class ; rdfs:label "Chronic monilial nail infection" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0008398 obo:IAO_0000115 "A nail of the fifth finger that is diminished in length and width, i.e., underdeveloped nail of little finger." ; oboInOwl:hasAlternativeId "HP:0200103" ; oboInOwl:hasDbXref "UMLS:C4024682" ; oboInOwl:hasExactSynonym "Underdeveloped fifth fingernail", "Underdeveloped fingernail of little finger", "Underdeveloped fingernail of pinkie finger", "Underdeveloped fingernail of pinky finger" ; oboInOwl:id "HP:0008398" ; a owl:Class ; rdfs:label "Hypoplastic fifth fingernail" ; rdfs:subClassOf obo:HP_0001804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008399 obo:IAO_0000115 "A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails." ; oboInOwl:hasDbXref "UMLS:C4024681" ; oboInOwl:hasExactSynonym "Thick skin around nails" ; oboInOwl:id "HP:0008399" ; a owl:Class ; rdfs:label "Circumungual hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0100803 . obo:HP_0008400 obo:IAO_0000115 "Detachment of the distal fingernails from the nail bed." ; oboInOwl:hasDbXref "UMLS:C4024680" ; oboInOwl:hasExactSynonym "Detachment of outermost fingernails" ; oboInOwl:id "HP:0008400" ; a owl:Class ; rdfs:label "Onycholysis of distal fingernails" ; rdfs:subClassOf obo:HP_0040039 . obo:HP_0008401 obo:IAO_0000115 "Thickened toenails." ; oboInOwl:hasAlternativeId "HP:0008395", "HP:0008405" ; oboInOwl:hasDbXref "UMLS:C4024679" ; oboInOwl:hasExactSynonym "Overgrowth and curving of toenails" ; oboInOwl:id "HP:0008401" ; a owl:Class ; rdfs:label "Onychogryposis of toenails" ; rdfs:subClassOf obo:HP_0001805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008402 obo:IAO_0000115 "Longitudinal, linear prominences in the fingernail plate." ; oboInOwl:hasDbXref "UMLS:C1849392" ; oboInOwl:hasExactSynonym "Longitudinally grooved fingernails", "Ridged fingernail" ; oboInOwl:hasRelatedSynonym "Ridged fingernails" ; oboInOwl:id "HP:0008402" ; a owl:Class ; rdfs:label "Ridged fingernail" ; rdfs:subClassOf obo:HP_0001231 . obo:HP_0008404 obo:IAO_0000115 "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate." ; oboInOwl:hasAlternativeId "HP:0008382", "HP:0008397", "HP:0008408" ; oboInOwl:hasDbXref "MEDDRA:10028698", "SNOMEDCT_US:87065009", "UMLS:C0221260" ; oboInOwl:hasExactSynonym "Dystrophic nails", "Onychodystrophy", "Poor nail formation" ; oboInOwl:id "HP:0008404" ; a owl:Class ; rdfs:comment "Onychodystrophy is a widely used, yet rarely defined term. Onychodystrophy can be caused by congenital nail diseases, systemic disorders, fungal and nonfungal infections, various noninfectious inflammatory dermatologic diseases of the nail unit and tumors. Onychodystrophy can also occur secondarily to systemic drug use." ; rdfs:label "Nail dystrophy" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001780 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008407 oboInOwl:hasDbXref "UMLS:C1855290" ; oboInOwl:hasExactSynonym "Tightly curved thumb nail" ; oboInOwl:id "HP:0008407" ; a owl:Class ; rdfs:label "Hyperconvex thumb nails" ; rdfs:subClassOf obo:HP_0001795 . obo:HP_0008410 oboInOwl:hasDbXref "UMLS:C1852311" ; oboInOwl:id "HP:0008410" ; a owl:Class ; rdfs:label "Subungual hyperkeratotic fragments" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0009723 . obo:HP_0008414 oboInOwl:hasDbXref "UMLS:C1863423" ; oboInOwl:hasExactSynonym "Hunched back in infancy", "Round back in infancy" ; oboInOwl:id "HP:0008414" ; a owl:Class ; rdfs:label "Lumbar kyphosis in infancy" ; rdfs:subClassOf obo:HP_0008454 . obo:HP_0008416 oboInOwl:hasDbXref "UMLS:C1839279" ; oboInOwl:id "HP:0008416" ; a owl:Class ; rdfs:label "Six lumbar vertebrae" ; rdfs:subClassOf obo:HP_0002946 . obo:HP_0008417 obo:IAO_0000115 "Small, underdeveloped vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0008431" ; oboInOwl:hasDbXref "SNOMEDCT_US:205456006", "UMLS:C0345394" ; oboInOwl:hasExactSynonym "Underdeveloped vertebrae" ; oboInOwl:id "HP:0008417" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vertebral hypoplasia" ; rdfs:subClassOf obo:HP_0008515 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008418 oboInOwl:hasDbXref "UMLS:C1849051" ; oboInOwl:id "HP:0008418" ; a owl:Class ; rdfs:label "Squared-off platyspondyly" ; rdfs:subClassOf obo:HP_0000926 . obo:HP_0008419 obo:IAO_0000115 "The presence of degenerative changes of intervertebral disk." ; oboInOwl:hasDbXref "MSH:D055959", "SNOMEDCT_US:77547008", "UMLS:C0158266" ; oboInOwl:hasExactSynonym "Degeneration of intervertebral discs", "Degeneration of intervertebral disks", "Degenerative disc disease", "Degenerative intervertebral disc", "Degenerative intervertebral disk" ; oboInOwl:id "HP:0008419" ; a owl:Class ; rdfs:label "Intervertebral disc degeneration" ; rdfs:subClassOf obo:HP_0005108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008420 obo:IAO_0000115 "The presence of punctiform calcification of the bone of the vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C4024678" ; oboInOwl:id "HP:0008420" ; a owl:Class ; rdfs:label "Punctate vertebral calcifications" ; rdfs:subClassOf obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0008421 oboInOwl:hasDbXref "UMLS:C1863313" ; oboInOwl:id "HP:0008421" ; a owl:Class ; rdfs:label "Tall lumbar vertebral bodies" ; rdfs:subClassOf obo:HP_0004570 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008422 obo:IAO_0000115 "An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other." ; oboInOwl:hasDbXref "UMLS:C1695776" ; oboInOwl:hasExactSynonym "Wedge-shaped vertebrae", "Wedged vertebrae", "anterior wedging" ; oboInOwl:id "HP:0008422" ; a owl:Class ; rdfs:label "Vertebral wedging" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001955 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008423 obo:IAO_0000115 "The presence of developmental dysplasia of the vertebral column." ; oboInOwl:hasDbXref "UMLS:C4021853" ; oboInOwl:id "HP:0008423" ; a owl:Class ; rdfs:label "Spinal dysplasia" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008424 oboInOwl:hasDbXref "UMLS:C1859366" ; oboInOwl:hasExactSynonym "Underdeveloped 5th lumbar vertebrae" ; oboInOwl:id "HP:0008424" ; a owl:Class ; rdfs:label "Hypoplastic 5th lumbar vertebrae" ; rdfs:subClassOf obo:HP_0008417 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004621 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008425 oboInOwl:hasDbXref "UMLS:C1855289" ; oboInOwl:id "HP:0008425" ; a owl:Class ; rdfs:label "Cuboid-shaped thoracolumbar vertebral bodies" ; rdfs:subClassOf obo:HP_0004634 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001872 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009568 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008428 obo:IAO_0000115 "Schisis (cleft or cleavage) of vertebral bodies." ; oboInOwl:hasAlternativeId "HP:0000942" ; oboInOwl:hasDbXref "UMLS:C1855828" ; oboInOwl:hasExactSynonym "Vertebral clefts" ; oboInOwl:id "HP:0008428" ; a owl:Class ; rdfs:comment "Cleft vertebrae result when there are two, instead of one, primary ossification centers in a vertebral body. An unossified cartilaginous brdige may be observed radiographically with the shape of a cleft. If the two ossification centers are ventral/dorsal, a coronal cleft is observed, and if the two ossification centers are left/right, than a sagittal cleft is observed." ; rdfs:label "Vertebral clefting" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008430 obo:IAO_0000115 "Anterior tongue-like protrusions of the vertebral bodies of the lumbar spine." ; oboInOwl:hasAlternativeId "HP:0005664" ; oboInOwl:hasDbXref "UMLS:C4021541" ; oboInOwl:hasExactSynonym "Anterior tongue-like protrusion of lumbar vertebral bodies" ; oboInOwl:id "HP:0008430" ; a owl:Class ; rdfs:label "Anterior beaking of lumbar vertebrae" ; rdfs:subClassOf obo:HP_0004568 . obo:HP_0008432 obo:IAO_0000115 "An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front)." ; oboInOwl:hasDbXref "UMLS:C4024677" ; oboInOwl:id "HP:0008432" ; a owl:Class ; rdfs:label "Anterior wedging of L1" ; rdfs:subClassOf obo:HP_0008422 . obo:HP_0008433 oboInOwl:hasDbXref "UMLS:C4024676" ; oboInOwl:id "HP:0008433" ; a owl:Class ; rdfs:label "Reversed usual vertebral column curves" ; rdfs:subClassOf obo:HP_0000925 . obo:HP_0008434 oboInOwl:hasAlternativeId "HP:0008415" ; oboInOwl:hasDbXref "UMLS:C1835570" ; oboInOwl:hasExactSynonym "Cervical vertebrae hypoplasia", "Underdeveloped cervical vertebrae" ; oboInOwl:id "HP:0008434" ; a owl:Class ; rdfs:label "Hypoplastic cervical vertebrae" ; rdfs:subClassOf obo:HP_0008417, obo:HP_0011041 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008435 oboInOwl:hasDbXref "UMLS:C1842698" ; oboInOwl:id "HP:0008435" ; a owl:Class ; rdfs:label "Absent in utero ossification of vertebral bodies" ; rdfs:subClassOf obo:HP_0004606 . obo:HP_0008436 oboInOwl:hasDbXref "UMLS:C1856644" ; oboInOwl:hasExactSynonym "Absent/small tailbone", "Absent/underdeveloped tailbone" ; oboInOwl:id "HP:0008436" ; a owl:Class ; rdfs:label "Absent/hypoplastic coccyx" ; rdfs:subClassOf obo:HP_0008517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008437 oboInOwl:hasDbXref "UMLS:C2751478" ; oboInOwl:id "HP:0008437" ; a owl:Class ; rdfs:label "Bifid thoracic vertebrae" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008438 obo:IAO_0000115 "A morphological abnormality of the vertebral arch, i.e., of the posterior part of a vertebra." ; oboInOwl:hasDbXref "UMLS:C1835764" ; oboInOwl:hasExactSynonym "Vertebral arch abnormalities" ; oboInOwl:id "HP:0008438" ; a owl:Class ; rdfs:comment "A vertebral arch is the posterior part of a vertebra and forms the canal through which the spinal cord passes. A vertebral arch consists of (i) a pair of vertebral pedicles, which are short thick processes that extend from the vertebral body to connect the body to the vertebral arch; (ii) a pari of vertebral laminae (broad plates that extending dorsally and medially from the pedicles fusing with one another to complete the roof of the vertebral arch); (iii) the spinous process (a process that is directed backward and downward from the junction of the laminae and to which muscles and ligaments attach); (iv) two superior articular processes and two inferior articular processes that articulate between two adjacent vertebrae); and (v) two transverse processes that extend at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes and allow the attachment of muscles and ligaments." ; rdfs:label "Vertebral arch anomaly" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008439 obo:IAO_0000115 "Absence of one half of the vertebral body in the lumbar spine." ; oboInOwl:hasDbXref "SNOMEDCT_US:93167001", "UMLS:C0432149" ; oboInOwl:id "HP:0008439" ; a owl:Class ; rdfs:label "Lumbar hemivertebrae" ; rdfs:subClassOf obo:HP_0002937 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002937 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008440 obo:IAO_0000115 "Any abnormality of the atlas and the axis." ; oboInOwl:hasDbXref "UMLS:C4024675" ; oboInOwl:id "HP:0008440" ; a owl:Class ; rdfs:comment "The atlas is the first cervical vertebral body and the axis is the second vertebral body." ; rdfs:label "C1-C2 vertebral abnormality" ; rdfs:subClassOf obo:HP_0003319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001093 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008441 obo:IAO_0000115 "The presence of one or more herniated nucleus pulposus of intervertebral disk." ; oboInOwl:hasBroadSynonym "Herniated disc", "Herniated disk" ; oboInOwl:hasDbXref "MSH:D007405", "SNOMEDCT_US:73589001", "UMLS:C0021818", "UMLS:C1832597" ; oboInOwl:hasExactSynonym "Herniated intervertebral nuclei" ; oboInOwl:id "HP:0008441" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Herniation of intervertebral nuclei" ; rdfs:subClassOf obo:HP_0005108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000643 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002242 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008442 obo:IAO_0000115 "Excessive growth of the bones of the vertebral bodies." ; oboInOwl:hasDbXref "UMLS:C1834057" ; oboInOwl:id "HP:0008442" ; a owl:Class ; rdfs:label "Vertebral hyperostosis" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0100774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008443 obo:IAO_0000115 "A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures." ; oboInOwl:hasDbXref "SNOMEDCT_US:298380006", "UMLS:C0575157" ; oboInOwl:hasExactSynonym "Charcot spinal arthropathy", "Spinal deformities", "Spinal neuroarthropathy" ; oboInOwl:id "HP:0008443" ; a owl:Class ; rdfs:comment "Neuropathic spinal arthropathy presents almost exclusively in patients who have suffered traumatic spinal cord injury or less commonly, secondary to syringomyelia, meningocele, myelomeningocele, diabetes mellitus, peripheral neuropathies, anesthetic leprosy, congenital analgesia, Parkinson's disease, arachnoiditis, transverse myelitis, and others." ; rdfs:label "Neuropathic spinal arthropathy" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008444 obo:IAO_0000115 "An abnormality of the shape of vertebrae, such that they are wedge-shaped (narrow towards the back)." ; oboInOwl:hasDbXref "UMLS:C1969679" ; oboInOwl:hasExactSynonym "Posterior wedging" ; oboInOwl:id "HP:0008444" ; a owl:Class ; rdfs:label "Posterior wedging of vertebral bodies" ; rdfs:subClassOf obo:HP_0008422 . obo:HP_0008445 obo:IAO_0000115 "An abnormal narrowing of the cervical spinal canal." ; oboInOwl:hasDbXref "UMLS:C1844925" ; oboInOwl:hasExactSynonym "Narrow cervical spinal canal" ; oboInOwl:id "HP:0008445" ; a owl:Class ; rdfs:label "Cervical spinal canal stenosis" ; rdfs:subClassOf obo:HP_0003416 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014542 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008447 oboInOwl:hasDbXref "UMLS:C2751480" ; oboInOwl:id "HP:0008447" ; a owl:Class ; rdfs:label "Hypoplastic coccygeal vertebrae" ; rdfs:subClassOf obo:HP_0008417 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001095 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008449 oboInOwl:hasDbXref "UMLS:C1851129" ; oboInOwl:id "HP:0008449" ; a owl:Class ; rdfs:label "Progressive cervical vertebral spine fusion" ; rdfs:subClassOf obo:HP_0002949 . obo:HP_0008450 obo:IAO_0000115 "A reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces." ; oboInOwl:hasAlternativeId "HP:0008426", "HP:0008448", "HP:0008474" ; oboInOwl:hasDbXref "UMLS:C1832598" ; oboInOwl:hasExactSynonym "Interpedicular narrowing", "Narrow interpedicular space", "Narrow interpediculate distances", "Narrowing of interpediculate distances" ; oboInOwl:id "HP:0008450" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow vertebral interpedicular distance" ; rdfs:subClassOf obo:HP_0008438 . obo:HP_0008451 oboInOwl:hasDbXref "UMLS:C1856780" ; oboInOwl:id "HP:0008451" ; a owl:Class ; rdfs:label "Posterior vertebral hypoplasia" ; rdfs:subClassOf obo:HP_0008417 . obo:HP_0008452 oboInOwl:hasDbXref "UMLS:C1865124" ; oboInOwl:id "HP:0008452" ; a owl:Class ; rdfs:label "Wafer-thin platyspondyly" ; rdfs:subClassOf obo:HP_0004565 . obo:HP_0008453 oboInOwl:hasDbXref "SNOMEDCT_US:405772002", "UMLS:C0345392" ; oboInOwl:id "HP:0008453" ; a owl:Class ; rdfs:label "Congenital kyphoscoliosis" ; rdfs:subClassOf obo:HP_0002751 . obo:HP_0008454 obo:IAO_0000115 "Over curvature of the lumbar region." ; oboInOwl:hasAlternativeId "HP:0008487" ; oboInOwl:hasDbXref "UMLS:C1844818" ; oboInOwl:hasExactSynonym "Lumbar gibbus deformity", "Rounded lower back" ; oboInOwl:id "HP:0008454" ; a owl:Class ; rdfs:label "Lumbar kyphosis" ; rdfs:subClassOf obo:HP_0100712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002808 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008455 obo:IAO_0000115 "A developmental defect of the sacrum characterized by partial or disordered development of the sacrum in which portions of the sacrum, which normally is formed by fusion of five sacral vertebrae S1-S5, fail to form or fail to form normally." ; oboInOwl:hasDbXref "UMLS:C1851305" ; oboInOwl:hasExactSynonym "Absence of some of the sacral and coccygeal bones", "Partial sacral agenesis", "Sacral dysgenesis" ; oboInOwl:id "HP:0008455" ; a owl:Class ; rdfs:label "Dysplastic sacrum" ; rdfs:subClassOf obo:HP_0005107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008456 obo:IAO_0000115 "A partial dislocation of the intervertebral joint between the second and third cervical vertebrae." ; oboInOwl:hasDbXref "UMLS:C2678323" ; oboInOwl:id "HP:0008456" ; a owl:Class ; rdfs:label "C2-C3 subluxation" ; rdfs:subClassOf obo:HP_0003308 . obo:HP_0008457 obo:IAO_0000115 "Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine." ; oboInOwl:hasDbXref "UMLS:C1863734" ; oboInOwl:hasExactSynonym "Caudal narrowing of interpedicular distances" ; oboInOwl:id "HP:0008457" ; a owl:Class ; rdfs:label "Caudal interpedicular narrowing" ; rdfs:subClassOf obo:HP_0008450 . obo:HP_0008458 obo:IAO_0000115 "A progressive form of scoliosis with congenital onset." ; oboInOwl:hasDbXref "UMLS:C1857025" ; oboInOwl:id "HP:0008458" ; a owl:Class ; rdfs:label "Progressive congenital scoliosis" ; rdfs:subClassOf obo:HP_0002650 . obo:HP_0008459 obo:IAO_0000115 "Agenesis of one or more vertebrae of the cervical vertebral column." ; oboInOwl:hasDbXref "MSH:C562952", "SNOMEDCT_US:91880006", "UMLS:C0432160" ; oboInOwl:hasExactSynonym "Cervical vertebrae agenesis", "Missing cervical vertebrae" ; oboInOwl:id "HP:0008459" ; a owl:Class ; rdfs:label "Cervical vertebral agenesis" ; rdfs:subClassOf obo:HP_0011041 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008460 oboInOwl:hasDbXref "UMLS:C4024674" ; oboInOwl:hasExactSynonym "Underdeveloped spinal processes" ; oboInOwl:id "HP:0008460" ; a owl:Class ; rdfs:label "Hypoplastic spinal processes" ; rdfs:subClassOf obo:HP_0008518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001076 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008461 oboInOwl:hasDbXref "UMLS:C4024673" ; oboInOwl:id "HP:0008461" ; a owl:Class ; rdfs:label "Cervical vertebral facet hypoplasia" ; rdfs:subClassOf obo:HP_0011041 . obo:HP_0008462 oboInOwl:hasDbXref "UMLS:C1863314" ; oboInOwl:id "HP:0008462" ; a owl:Class ; rdfs:label "Cervical instability" ; rdfs:subClassOf obo:HP_0005881 . obo:HP_0008463 oboInOwl:hasDbXref "UMLS:C4024672" ; oboInOwl:id "HP:0008463" ; a owl:Class ; rdfs:label "Central vertebral hypoplasia" ; rdfs:subClassOf obo:HP_0008417 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008464 oboInOwl:hasDbXref "UMLS:C4024671" ; oboInOwl:id "HP:0008464" ; a owl:Class ; rdfs:label "Absent spinous processes of lower thoracic and lumbar vertebrae" ; rdfs:subClassOf obo:HP_0008516 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009568 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008465 obo:IAO_0000115 "A developmental defect characterized by agenesis of one or more vertebral bodies." ; oboInOwl:hasDbXref "SNOMEDCT_US:15843004", "UMLS:C0158776" ; oboInOwl:hasExactSynonym "Absent vertebrae" ; oboInOwl:id "HP:0008465" ; a owl:Class ; rdfs:label "Absent vertebra" ; rdfs:subClassOf obo:HP_0008515 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008467 obo:IAO_0000115 "Absence of one half of the vertebral body in the thoracic spine." ; oboInOwl:hasAlternativeId "HP:0004604" ; oboInOwl:hasDbXref "SNOMEDCT_US:95304000", "UMLS:C0432152", "UMLS:C4020799" ; oboInOwl:hasNarrowSynonym "Midthoracic hemivertebrae" ; oboInOwl:id "HP:0008467" ; a owl:Class ; rdfs:label "Thoracic hemivertebrae" ; rdfs:subClassOf obo:HP_0002937 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002937 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008468 obo:IAO_0000115 "An abnormality related to a defect of vertebral separation of sacral vertebrae during development." ; oboInOwl:hasDbXref "UMLS:C1968942" ; oboInOwl:id "HP:0008468" ; a owl:Class ; rdfs:label "Abnormal sacral segmentation" ; rdfs:subClassOf obo:HP_0008490 . obo:HP_0008469 obo:IAO_0000115 "Dysplasia of the cervical vertebral column." ; oboInOwl:hasDbXref "MSH:C566140", "UMLS:C1861693" ; oboInOwl:id "HP:0008469" ; a owl:Class ; rdfs:label "Cervical vertebral dysplasia" ; rdfs:subClassOf obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008470 obo:IAO_0000115 "A reduction of the distance between the lower thoracic vertebral pedicles." ; oboInOwl:hasDbXref "UMLS:C1854940" ; oboInOwl:hasExactSynonym "Narrowness of interpediculate distances in lower thoracic regions" ; oboInOwl:id "HP:0008470" ; a owl:Class ; rdfs:label "Lower thoracic interpediculate narrowness" ; rdfs:subClassOf obo:HP_0008450 . obo:HP_0008472 oboInOwl:hasBroadSynonym "Large tailbone" ; oboInOwl:hasDbXref "UMLS:C1850044", "UMLS:C4280412" ; oboInOwl:hasExactSynonym "Prominent protruding tailbone" ; oboInOwl:id "HP:0008472" ; a owl:Class ; rdfs:label "Prominent protruding coccyx" ; rdfs:subClassOf obo:HP_0040016, obo:HP_0040017 . obo:HP_0008473 obo:IAO_0000115 "An abnormal reduction of the anterioposterior diameter of the vertebral body." ; oboInOwl:hasAlternativeId "HP:0005732" ; oboInOwl:hasDbXref "UMLS:C4021540" ; oboInOwl:hasExactSynonym "Reduced anterior-posterior diameter of vertebral bodies", "Reduced sagittal diameter of vertebrae" ; oboInOwl:id "HP:0008473" ; a owl:Class ; rdfs:label "Narrow anterio-posterior vertebral body diameter" ; rdfs:subClassOf obo:HP_0008479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008475 oboInOwl:hasDbXref "UMLS:C2751479" ; oboInOwl:id "HP:0008475" ; a owl:Class ; rdfs:label "Hypoplastic sacral vertebrae" ; rdfs:subClassOf obo:HP_0004590, obo:HP_0008417 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008476 oboInOwl:hasAlternativeId "HP:0004624" ; oboInOwl:hasDbXref "UMLS:C1868554" ; oboInOwl:hasExactSynonym "irregular, dense end plate" ; oboInOwl:id "HP:0008476" ; a owl:Class ; rdfs:label "Irregular sclerotic endplates" ; rdfs:subClassOf obo:HP_0003301 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0003301 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008477 obo:IAO_0000115 "Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set." ; oboInOwl:hasDbXref "UMLS:C4024670" ; oboInOwl:id "HP:0008477" ; a owl:Class ; rdfs:label "Poorly ossified cervical vertebrae" ; rdfs:subClassOf obo:HP_0100856 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008478 oboInOwl:hasDbXref "UMLS:C1844926" ; oboInOwl:id "HP:0008478" ; a owl:Class ; rdfs:label "Scheuermann-like vertebral changes" ; rdfs:subClassOf obo:HP_0010891 . obo:HP_0008479 oboInOwl:hasAlternativeId "HP:0002773" ; oboInOwl:hasDbXref "UMLS:C1863353" ; oboInOwl:hasExactSynonym "Small vertebrae", "Small vertebral bodies", "Underdeveloped back bones" ; oboInOwl:id "HP:0008479" ; a owl:Class ; rdfs:label "Hypoplastic vertebral bodies" ; rdfs:subClassOf obo:HP_0003312, obo:HP_0008417 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001075 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008480 obo:IAO_0000115 "Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column." ; oboInOwl:hasAlternativeId "HP:0025266" ; oboInOwl:hasDbXref "MSH:D055009", "SNOMEDCT_US:387800004", "SNOMEDCT_US:387801000", "UMLS:C0263854", "UMLS:C1384641" ; oboInOwl:hasExactSynonym "Cervical osteoarthritis", "Cervical spine degeneration", "Neck arthritis" ; oboInOwl:id "HP:0008480" ; a owl:Class ; rdfs:comment "When osteoarthritis affects the spine, it is known as spondylosis." ; rdfs:label "Cervical spondylosis" ; rdfs:subClassOf obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_27 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006072 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008482 oboInOwl:hasDbXref "UMLS:C4024669" ; oboInOwl:id "HP:0008482" ; a owl:Class ; rdfs:label "Asymmetry of spinal facet joints" ; rdfs:subClassOf obo:HP_0030870 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008483 oboInOwl:hasDbXref "UMLS:C1847393" ; oboInOwl:id "HP:0008483" ; a owl:Class ; rdfs:label "Cervical vertebral bodies with decreased anteroposterior diameter" ; rdfs:subClassOf obo:HP_0003319 . obo:HP_0008484 obo:IAO_0000115 "A reduction of the distance between thoracolumbar vertebral pedicles." ; oboInOwl:hasDbXref "UMLS:C1864364" ; oboInOwl:hasExactSynonym "Narrow thoracolumbar interpediculate distance" ; oboInOwl:id "HP:0008484" ; a owl:Class ; rdfs:label "Thoracolumbar interpediculate narrowness" ; rdfs:subClassOf obo:HP_0008450 . obo:HP_0008486 obo:IAO_0000115 "Narrowing (becoming gradually narrower) of the distance between lumbar vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column." ; oboInOwl:hasDbXref "UMLS:C1849079" ; oboInOwl:hasExactSynonym "Decreasing lumbar vertebrae interpediculate distance" ; oboInOwl:id "HP:0008486" ; a owl:Class ; rdfs:label "Lumbar interpedicular narrowing" ; rdfs:subClassOf obo:HP_0008457 . obo:HP_0008488 oboInOwl:hasDbXref "UMLS:C1850043" ; oboInOwl:id "HP:0008488" ; a owl:Class ; rdfs:label "Anterior rounding of vertebral bodies" ; rdfs:subClassOf obo:HP_0003300 . obo:HP_0008489 obo:IAO_0000115 "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the fifth lumbar vertebral body (L5) onto the sacrum (level S1)." ; oboInOwl:hasAlternativeId "HP:0005779" ; oboInOwl:hasDbXref "UMLS:C3275799" ; oboInOwl:hasExactSynonym "Spondylolysis and spondylolisthesis of l5" ; oboInOwl:id "HP:0008489" ; a owl:Class ; rdfs:label "Spondylolisthesis at L5-S1" ; rdfs:subClassOf obo:HP_0003302 . obo:HP_0008490 oboInOwl:hasDbXref "UMLS:C1850329" ; oboInOwl:id "HP:0008490" ; a owl:Class ; rdfs:label "Sacral segmentation defect" ; rdfs:subClassOf obo:HP_0003422, obo:HP_0005107 . obo:HP_0008491 obo:IAO_0000115 "Early closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life." ; oboInOwl:hasDbXref "UMLS:C4024668" ; oboInOwl:id "HP:0008491" ; a owl:Class ; rdfs:label "Premature anterior fontanel closure" ; rdfs:subClassOf obo:HP_0000236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002166 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008494 obo:IAO_0000115 "Partial displacement of the lens in the inferior direction." ; oboInOwl:hasDbXref "UMLS:C2036842" ; oboInOwl:hasExactSynonym "Inferior subluxated lens" ; oboInOwl:id "HP:0008494" ; a owl:Class ; rdfs:label "Inferior lens subluxation" ; rdfs:subClassOf obo:HP_0001132 . obo:HP_0008496 oboInOwl:hasDbXref "SNOMEDCT_US:95339000", "UMLS:C0423848", "UMLS:C3550336" ; oboInOwl:hasExactSynonym "Extra rows of eyelashes", "Multiple rows of eyelashes" ; oboInOwl:hasNarrowSynonym "Double row of eyelashes", "Two rows of eyelashes" ; oboInOwl:id "HP:0008496" ; a owl:Class ; rdfs:label "Multiple rows of eyelashes" ; rdfs:subClassOf obo:HP_0000499 . obo:HP_0008497 oboInOwl:hasDbXref "UMLS:C4024667" ; oboInOwl:id "HP:0008497" ; a owl:Class ; rdfs:label "Congenital craniofacial dysostosis" ; rdfs:subClassOf obo:HP_0004439 . obo:HP_0008498 oboInOwl:hasDbXref "UMLS:C4024666" ; oboInOwl:hasExactSynonym "Absence of adult teeth", "Absence of secondary dentition", "Missing adult teeth", "No adult dentition", "No secondary dentition" ; oboInOwl:id "HP:0008498" ; a owl:Class ; rdfs:label "No permanent dentition" ; rdfs:subClassOf obo:HP_0000696 . obo:HP_0008499 obo:IAO_0000115 "A severe form of hypermetropia with over +5.00 diopters." ; oboInOwl:hasDbXref "UMLS:C4024665" ; oboInOwl:hasExactSynonym "High hyperopia", "High-grade hypermetropia", "Severe farsightedness", "Severe long-sightedness" ; oboInOwl:id "HP:0008499" ; a owl:Class ; rdfs:label "High hypermetropia" ; rdfs:subClassOf obo:HP_0000540 . obo:HP_0008501 obo:IAO_0000115 "Cleft lip or palate affecting the midline region of the palate." ; oboInOwl:hasAlternativeId "HP:0009089" ; oboInOwl:hasDbXref "UMLS:C2750604" ; oboInOwl:hasExactSynonym "Central cleft lip and palate", "Medial cleft lip and palate", "Midline cleft lip/palate", "Wide midline cleft lip/palate" ; oboInOwl:id "HP:0008501" ; a owl:Class ; rdfs:label "Median cleft lip and palate" ; rdfs:subClassOf obo:HP_0000161, obo:HP_0009099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000161 obo:HP_0000175 ) ] ] . obo:HP_0008504 obo:IAO_0000115 "The presence of a moderate form of sensorineural hearing impairment." ; oboInOwl:hasDbXref "UMLS:C4020798", "UMLS:C4024664" ; oboInOwl:hasRelatedSynonym "Moderate neural deafness" ; oboInOwl:id "HP:0008504" ; a owl:Class ; rdfs:label "Moderate sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407, obo:HP_0012713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008507 oboInOwl:hasDbXref "UMLS:C4024663" ; oboInOwl:id "HP:0008507" ; a owl:Class ; rdfs:label "Static ophthalmoparesis" ; rdfs:subClassOf obo:HP_0000597 . obo:HP_0008509 oboInOwl:hasDbXref "UMLS:C3550331" ; oboInOwl:id "HP:0008509" ; a owl:Class ; rdfs:label "Aged leonine appearance" ; rdfs:subClassOf obo:HP_0007495 . obo:HP_0008511 obo:IAO_0000115 "Reduced transparency of the central posterior portion of the corneal stroma." ; oboInOwl:hasDbXref "SNOMEDCT_US:246967007", "UMLS:C0423260" ; oboInOwl:id "HP:0008511" ; a owl:Class ; rdfs:label "Central posterior corneal opacity" ; rdfs:subClassOf obo:HP_0011493 . obo:HP_0008513 obo:IAO_0000115 "A bilateral type of conductive hearing impairment." ; oboInOwl:hasAlternativeId "HP:0008536" ; oboInOwl:hasDbXref "SNOMEDCT_US:194417009", "UMLS:C0452136" ; oboInOwl:hasExactSynonym "Bilateral conductive deafness", "Bilateral conductive hearing loss" ; oboInOwl:id "HP:0008513" ; a owl:Class ; rdfs:label "Bilateral conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0055127 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0008515 dcterms:creator ; oboInOwl:creation_date "2008-04-04T02:30:00Z" ; oboInOwl:hasDbXref "UMLS:C4024662" ; oboInOwl:hasExactSynonym "Absent/small vertebrae", "Absent/underdeveloped vertebrae" ; oboInOwl:id "HP:0008515" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the vertebrae" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0008518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008516 dcterms:creator ; oboInOwl:creation_date "2008-04-04T02:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4024661" ; oboInOwl:id "HP:0008516" ; a owl:Class ; rdfs:label "Abnormality of the vertebral spinous processes" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001076 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008517 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the sacral bone." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T02:32:00Z" ; oboInOwl:hasDbXref "UMLS:C4024660" ; oboInOwl:hasExactSynonym "Absent/small sacrum", "Absent/underdeveloped sacrum" ; oboInOwl:id "HP:0008517" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the sacrum" ; rdfs:subClassOf obo:HP_0005107, obo:HP_0008518 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008518 dcterms:creator ; oboInOwl:creation_date "2008-04-04T02:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4024659" ; oboInOwl:hasExactSynonym "Absent/small backbone", "Absent/small spine", "Absent/small vertebral column", "Absent/underdeveloped backbone", "Absent/underdeveloped spine", "Absent/underdeveloped vertebral column" ; oboInOwl:id "HP:0008518" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the vertebral column" ; rdfs:subClassOf obo:HP_0000925, obo:HP_0009122 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008519 obo:IAO_0000115 "Any structural abnormality of the coccyx." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T02:41:00Z" ; oboInOwl:hasAlternativeId "HP:0002830" ; oboInOwl:hasDbXref "UMLS:C4024658" ; oboInOwl:hasExactSynonym "Abnormal tailbone", "Abnormality of the coccyx" ; oboInOwl:id "HP:0008519" ; a owl:Class ; rdfs:label "Abnormal coccyx morphology" ; rdfs:subClassOf obo:HP_0000925, obo:HP_0002644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008523 obo:IAO_0000115 "Permanent indentation on the posteromedial aspect of the helix that may be sharply or indistinctly delineated." ; oboInOwl:hasDbXref "UMLS:C4021539" ; oboInOwl:hasExactSynonym "Ear, posterior helical groove", "Ear, posterior helical notch", "Helix, posterior pit", "Indentation in back of outer ear", "Pits in posterior aspect of ear helices" ; oboInOwl:id "HP:0008523" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "They are usually linear to a narrow oval in shape and may be single or multiple." ; rdfs:label "Posterior helix pit" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0008527 obo:IAO_0000115 "A type of hearing impairment caused by an abnormal functionality of the cochlear nerve with congenital onset." ; oboInOwl:hasAlternativeId "HP:0004455", "HP:0004457", "HP:0008520", "HP:0008521", "HP:0008540", "HP:0008543", "HP:0008545", "HP:0008546", "HP:0008556", "HP:0008558", "HP:0008561", "HP:0008571", "HP:0008603", "HP:0008612", "HP:0008620" ; oboInOwl:hasDbXref "SNOMEDCT_US:700453005", "UMLS:C1865866" ; oboInOwl:hasExactSynonym "Bilateral congenital sensorineural deafness", "Congenital neurosensory deafness", "Congenital perceptive deafness", "Congenital sensorineural deafness", "Congenital sensorineural hearing loss", "Hearing loss, congenital sensorineural" ; oboInOwl:id "HP:0008527" ; a owl:Class ; rdfs:label "Congenital sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0008528 oboInOwl:hasBroadSynonym "Ear hair" ; oboInOwl:hasDbXref "SNOMEDCT_US:27394002", "UMLS:C0222050", "UMLS:C4024657" ; oboInOwl:hasExactSynonym "Long hairs growing from helix of ear" ; oboInOwl:id "HP:0008528" ; a owl:Class ; rdfs:label "Long hairs growing from helix of pinna" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0008529 obo:IAO_0000115 "Absence of the acoustic reflex, an involuntary contraction of the stapedius muscle that occurs in response to high-intensity sound stimuli." ; oboInOwl:hasAlternativeId "HP:0008595" ; oboInOwl:hasDbXref "UMLS:C1832834" ; oboInOwl:hasExactSynonym "Absence of acoustic middle ear muscle reflexes", "Absent middle ear reflexes" ; oboInOwl:id "HP:0008529" ; a owl:Class ; rdfs:comment "Note that the acoustic reflex is also referred to as stapedius reflex, attenuation reflex, or auditory reflex." ; rdfs:label "Absence of acoustic reflex" ; rdfs:subClassOf obo:HP_0040121 . obo:HP_0008537 oboInOwl:hasDbXref "UMLS:C1865302" ; oboInOwl:hasExactSynonym "Cleft at the superior portion of the ear" ; oboInOwl:id "HP:0008537" ; a owl:Class ; rdfs:comment "This term is used for Auriculocondylar syndrome (MIM:602483). Not clear if there is a clean delineation against cleft helix." ; rdfs:label "Cleft at the superior portion of the pinna" ; rdfs:subClassOf obo:HP_0009902 . obo:HP_0008541 oboInOwl:hasDbXref "UMLS:C1850190" ; oboInOwl:hasRelatedSynonym "High set ears" ; oboInOwl:id "HP:0008541" ; a owl:Class ; rdfs:label "Superiorly displaced ears" ; rdfs:subClassOf obo:HP_0000357 . obo:HP_0008542 obo:IAO_0000115 "A type of hearing impairment affecting primarily the low frequencies of sound (125 Hz to 1000 Hz)." ; oboInOwl:hasDbXref "SNOMEDCT_US:42538001", "UMLS:C0271514" ; oboInOwl:hasExactSynonym "Low-frequency hearing loss" ; oboInOwl:id "HP:0008542" ; a owl:Class ; rdfs:label "Low-frequency hearing loss" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0008544 obo:IAO_0000115 "Any structural anomaly of the border of the helix, which usually forms a rolled rim but is highly variable in shape." ; oboInOwl:hasDbXref "UMLS:C1970777" ; oboInOwl:id "HP:0008544" ; a owl:Class ; rdfs:label "Abnormally folded helix" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001910 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008551 obo:IAO_0000115 "Underdevelopment of the external ear." ; oboInOwl:hasAlternativeId "HP:0000393", "HP:0000409", "HP:0008550", "HP:0008618", "HP:0008621" ; oboInOwl:hasDbXref "MSH:D065817", "SNOMEDCT_US:35045004", "UMLS:C0152423" ; oboInOwl:hasExactSynonym "Bilateral microtia", "Hypoplasia of the external ear", "Hypoplastic ears", "Hypoplastic pinna", "Small ears", "Small pinnae", "Underdeveloped ears" ; oboInOwl:id "HP:0008551" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The definitions of microtia follow a widely used, surgically based, classification of ear anomalies outlined by Weerda 1988. As microtia indicates at least both decreased length and width, and in more severe forms it includes abnormal shape of structures, all forms are acknowledged to be bundled terms, but are retained here because they are well established." ; rdfs:label "Microtia" ; rdfs:subClassOf obo:HP_0008772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008554 obo:IAO_0000115 "The presence of a malformed cochlea." ; oboInOwl:hasDbXref "UMLS:C1862050" ; oboInOwl:id "HP:0008554" ; a owl:Class ; rdfs:comment "A cochlear malformation may include a membranous abnormality, a bony abnormality, or a combination of the two." ; rdfs:label "Cochlear malformation" ; rdfs:subClassOf obo:HP_0000375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008555 obo:IAO_0000115 "Complete lack of functioning of the vestibular apparatus." ; oboInOwl:hasDbXref "UMLS:C4024656" ; oboInOwl:id "HP:0008555" ; a owl:Class ; rdfs:label "Absent vestibular function" ; rdfs:subClassOf obo:HP_0001756 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008559 oboInOwl:hasAlternativeId "HP:0008627" ; oboInOwl:hasDbXref "UMLS:C1865305" ; oboInOwl:hasExactSynonym "Underdeveloped superior helices" ; oboInOwl:id "HP:0008559" ; a owl:Class ; rdfs:label "Hypoplastic superior helix" ; rdfs:subClassOf obo:HP_0008589 . obo:HP_0008568 obo:IAO_0000115 "Vestibular areflexia can be measured as the absence of the caloric nystagmus response in electronystagmography." ; oboInOwl:hasAlternativeId "HP:0008526" ; oboInOwl:hasDbXref "SNOMEDCT_US:22443004", "UMLS:C0235927", "UMLS:C4015052" ; oboInOwl:hasRelatedSynonym "Vestibular ataxia" ; oboInOwl:id "HP:0008568" ; a owl:Class ; rdfs:label "Vestibular areflexia" ; rdfs:subClassOf obo:HP_0007670 . obo:HP_0008569 obo:IAO_0000115 "Median longitudinal length of the ear more than two standard deviations below the mean in the presence of some, but not all, parts of the normal ear." ; oboInOwl:hasDbXref "UMLS:C4020694", "UMLS:C4020792", "UMLS:C4020793", "UMLS:C4020794", "UMLS:C4020795", "UMLS:C4020796", "UMLS:C4020797" ; oboInOwl:hasRelatedSynonym "Cockleshell ear", "Constricted helix type IV", "Ear, grade II dysplasia", "Mini ear", "Severe cupped ear, type III", "Shell ear", "Snail ear" ; oboInOwl:id "HP:0008569" ; a owl:Class ; rdfs:label "Microtia, second degree" ; rdfs:subClassOf obo:HP_0008551 . obo:HP_0008572 obo:IAO_0000115 "A malformation of the auricle of the ear." ; oboInOwl:hasAlternativeId "HP:0008594" ; oboInOwl:hasDbXref "UMLS:C1846460" ; oboInOwl:hasExactSynonym "External ear malformation" ; oboInOwl:id "HP:0008572" ; a owl:Class ; rdfs:label "External ear malformation" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008573 obo:IAO_0000115 "A form of sensorineural hearing impairment that affects primarily the lower frequencies." ; oboInOwl:hasDbXref "UMLS:C3810445" ; oboInOwl:hasExactSynonym "Low-frequency sensorineural hearing loss" ; oboInOwl:id "HP:0008573" ; a owl:Class ; rdfs:label "Low-frequency sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0008577 obo:IAO_0000115 "Underdevelopment of the helix that either affects the entire helix, or is localized." ; oboInOwl:hasDbXref "UMLS:C1849735" ; oboInOwl:hasExactSynonym "Poorly folded helices" ; oboInOwl:id "HP:0008577" ; a owl:Class ; rdfs:comment "Helix folding is highly variable, and the range is illustrated in Figures 29 and 30. To use this term, the affected area must be too long to be considered a Cleft helix. Underdevelopment of part of the helix can lead to the impression that the scaphal area is enlarged." ; rdfs:label "Underfolded helix" ; rdfs:subClassOf obo:HP_0008544 . obo:HP_0008583 obo:IAO_0000115 "A condition in which the superior portion of the helix is folded over to a lesser degree than normal." ; oboInOwl:hasDbXref "UMLS:C4024655" ; oboInOwl:id "HP:0008583" ; a owl:Class ; rdfs:label "Underfolded superior helices" ; rdfs:subClassOf obo:HP_0008577 . obo:HP_0008586 obo:IAO_0000115 "Developmental hypoplasia of the cochlea." ; oboInOwl:hasDbXref "UMLS:C2676974" ; oboInOwl:hasExactSynonym "Hypoplastic cochlea", "Underdeveloped cochlea" ; oboInOwl:id "HP:0008586" ; a owl:Class ; rdfs:label "Hypoplasia of the cochlea" ; rdfs:subClassOf obo:HP_0011395 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008587 obo:IAO_0000115 "The presence of a mild form of sensorineural hearing impairment." ; oboInOwl:hasDbXref "UMLS:C4021538" ; oboInOwl:hasExactSynonym "Mild neurosensory hearing loss" ; oboInOwl:id "HP:0008587" ; a owl:Class ; rdfs:comment "A neurosensory hearing loss with a deficit of 21-40 dB." ; rdfs:label "Mild neurosensory hearing impairment" ; rdfs:subClassOf obo:HP_0000407, obo:HP_0012712 . obo:HP_0008588 obo:IAO_0000115 "A type of stenosis of the external auditory meatus in which the opening of the external auditory meatus appears as a vertical slit." ; oboInOwl:hasDbXref "UMLS:C1846459" ; oboInOwl:id "HP:0008588" ; a owl:Class ; rdfs:label "Slit-like opening of the exterior auditory meatus" ; rdfs:subClassOf obo:HP_0000402 . obo:HP_0008589 obo:IAO_0000115 "Underdevelopment of the helix, i.e., of the outer rim of the pinna." ; oboInOwl:hasDbXref "UMLS:C1842681" ; oboInOwl:hasExactSynonym "Underdeveloped helices" ; oboInOwl:id "HP:0008589" ; a owl:Class ; rdfs:label "Hypoplastic helices" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008591 obo:IAO_0000115 "A type of conductive deafness with congenital onset." ; oboInOwl:hasAlternativeId "HP:0008525" ; oboInOwl:hasDbXref "UMLS:C4021537" ; oboInOwl:hasExactSynonym "Congenital conductive deafness", "Congenital conductive hearing loss" ; oboInOwl:id "HP:0008591" ; a owl:Class ; rdfs:label "Congenital conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405 . obo:HP_0008593 obo:IAO_0000115 "Increased anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." ; oboInOwl:hasDbXref "UMLS:C1968811" ; oboInOwl:hasExactSynonym "Enlarged antitragus", "Hyperplastic antitragus", "Hypertrophic antitragus" ; oboInOwl:id "HP:0008593" ; a owl:Class ; rdfs:label "Prominent antitragus" ; rdfs:subClassOf obo:HP_0009896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008596 obo:IAO_0000115 "A form of sensorineural hearing impairment with onset after the acquisition of speech." ; oboInOwl:hasDbXref "UMLS:C4024654" ; oboInOwl:id "HP:0008596" ; a owl:Class ; rdfs:label "Postlingual sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0011474 . obo:HP_0008598 obo:IAO_0000115 "A mild form of conductive hearing impairment." ; oboInOwl:hasDbXref "UMLS:C4021536" ; oboInOwl:hasExactSynonym "Conductive hearing loss, mild" ; oboInOwl:id "HP:0008598" ; a owl:Class ; rdfs:comment "Conductive hearing impairment with 21-40 dB deficit." ; rdfs:label "Mild conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405, obo:HP_0012712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000405 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008605 oboInOwl:hasDbXref "UMLS:C1834043" ; oboInOwl:hasExactSynonym "Deformed external ear on one side" ; oboInOwl:id "HP:0008605" ; a owl:Class ; rdfs:label "Unilateral external ear deformity" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0008606 obo:IAO_0000115 "Benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit." ; oboInOwl:hasDbXref "UMLS:C1862059" ; oboInOwl:hasExactSynonym "Pit above the ear", "Supraauricular fistula", "Supraauricular sinus", "Supraauricular sinuses" ; oboInOwl:id "HP:0008606" ; a owl:Class ; rdfs:label "Supraauricular pit" ; rdfs:subClassOf obo:HP_0100277 . obo:HP_0008607 obo:IAO_0000115 "A progressive type of conductive deafness." ; oboInOwl:hasDbXref "UMLS:C1861325" ; oboInOwl:hasExactSynonym "Progressive conductive deafness" ; oboInOwl:id "HP:0008607" ; a owl:Class ; rdfs:label "Progressive conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000405 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0008608 oboInOwl:hasDbXref "UMLS:C1857263" ; oboInOwl:id "HP:0008608" ; a owl:Class ; rdfs:label "Hypertrophic auricular cartilage" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001848 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008609 obo:IAO_0000115 "An abnormality of the morphology or structure of the middle ear." ; oboInOwl:hasDbXref "UMLS:C1857456" ; oboInOwl:hasExactSynonym "Middle ear malformation", "Morphological abnormality of the middle ear" ; oboInOwl:id "HP:0008609" ; a owl:Class ; rdfs:label "Morphological abnormality of the middle ear" ; rdfs:subClassOf obo:HP_0000370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008610 obo:IAO_0000115 "A form of sensorineural hearing impairment with infantile onset." ; oboInOwl:hasDbXref "UMLS:C4021535" ; oboInOwl:hasExactSynonym "Infantile sensorineural hearing loss" ; oboInOwl:id "HP:0008610" ; a owl:Class ; rdfs:label "Infantile sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0011474 . obo:HP_0008615 obo:IAO_0000115 "The presence of sensorineural deafness with late onset." ; oboInOwl:hasAlternativeId "HP:0008532", "HP:0008599" ; oboInOwl:hasDbXref "UMLS:C4021534" ; oboInOwl:hasExactSynonym "Late sensorineural hearing loss", "Sensorineural deafness, late-onset" ; oboInOwl:id "HP:0008615" ; a owl:Class ; rdfs:label "Adult onset sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0008619 obo:IAO_0000115 "A bilateral form of sensorineural hearing impairment." ; oboInOwl:hasAlternativeId "HP:0008530", "HP:0008539", "HP:0008579", "HP:0008585" ; oboInOwl:hasDbXref "SNOMEDCT_US:194424005", "UMLS:C0452138" ; oboInOwl:hasExactSynonym "Bilateral nerve deafness", "Bilateral sensorineural deafness", "Bilateral sensorineural hearing loss", "Hearing loss, sensorineural, bilateral" ; oboInOwl:id "HP:0008619" ; a owl:Class ; rdfs:label "Bilateral sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0008625 obo:IAO_0000115 "A severe form of sensorineural hearing impairment." ; oboInOwl:hasAlternativeId "HP:0008534", "HP:0008574" ; oboInOwl:hasDbXref "UMLS:C4021533" ; oboInOwl:hasExactSynonym "Severe sensorineural deafness", "Severe sensorineural hearing loss" ; oboInOwl:id "HP:0008625" ; a owl:Class ; rdfs:label "Severe sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407, obo:HP_0012714 . obo:HP_0008628 obo:IAO_0000115 "An abnormality of the stapes, a stirrup-shaped ossicle in the middle ear." ; oboInOwl:hasDbXref "UMLS:C4021532" ; oboInOwl:hasExactSynonym "Stapedial abnormalities" ; oboInOwl:id "HP:0008628" ; a owl:Class ; rdfs:label "Abnormality of the stapes" ; rdfs:subClassOf obo:HP_0004452 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008629 obo:IAO_0000115 "Pulsatile tinnitus is generally classified a kind of objective tinnitus, meaning that it is not only audible to the patient but also to the examiner on auscultation of the auditory canal and/or of surrounding structures with use of an auscultation tube or stethoscope. Usually, pulsatile tinnitus is heard as a lower pitched thumping or booming, a rougher blowing sound which is coincidental with respiration, or as a clicking, higher pitched rhythmic sensation." ; oboInOwl:hasAlternativeId "HP:0000361" ; oboInOwl:hasDbXref "MSH:D014012", "SNOMEDCT_US:232322006", "UMLS:C0751559" ; oboInOwl:id "HP:0008629" ; a owl:Class ; rdfs:comment "Pulsatile tinnitus may be associated with vascular abnormalities such as arterioevenous shunts or glomus tumors or the jugular vein, arterial bruits related to a high-riding carotid artery (close to the auditory areas) or carotid stenosis, or venous abnormalities such as a dehiscent jugular bulb or to hypertension. Finally, in some patients, mechanical abnormalities such patulous eustachian tubes, palatomyoclonus (small spasms of muscles in the soft palate area), or idiopathic stapedial muscle spasm may represent the underlying cause of pulsatile tinnitus." ; rdfs:label "Pulsatile tinnitus" ; rdfs:subClassOf obo:HP_0000360 . obo:HP_0008631 obo:IAO_0000115 "A developmental anomaly of the ureter." ; oboInOwl:hasDbXref "UMLS:C4024653" ; oboInOwl:id "HP:0008631" ; a owl:Class ; rdfs:comment "If possible, a more specific term describing the precise type of ureteral dysgenesis should be chosen." ; rdfs:label "Ureteral dysgenesis" ; rdfs:subClassOf obo:HP_0025633 . obo:HP_0008633 obo:IAO_0000115 "Absence of sex glands (gonads are the organs that produce gametes; testis in males and ovary in females)." ; oboInOwl:hasDbXref "UMLS:C4024652" ; oboInOwl:hasExactSynonym "Absent gonadal tissue", "Gonadal agenesis" ; oboInOwl:id "HP:0008633" ; a owl:Class ; rdfs:comment "Gonadal agenesis refers to the lack of development of gonads during fetal development; it may not be possible clinically to determine if gonal tissue was present at any point of development. For this reason, we regard agonadism and gonadal agenesis as synonymous." ; rdfs:label "Agonadism" ; rdfs:subClassOf obo:HP_0000812 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008635 obo:IAO_0000115 "Abnormal enlargement of the urinary bladder." ; oboInOwl:hasDbXref "UMLS:C4021531" ; oboInOwl:hasExactSynonym "Hypertrophic urinary bladder" ; oboInOwl:id "HP:0008635" ; a owl:Class ; rdfs:label "Hypertrophy of the urinary bladder" ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008636 oboInOwl:hasDbXref "UMLS:C4024651" ; oboInOwl:id "HP:0008636" ; a owl:Class ; rdfs:label "Lobular glomerulopathy" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0008639 oboInOwl:hasDbXref "UMLS:C0239761" ; oboInOwl:hasExactSynonym "Underdeveloped gonad" ; oboInOwl:id "HP:0008639" ; a owl:Class ; rdfs:label "Gonadal hypoplasia" ; rdfs:subClassOf obo:HP_0000812 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000991 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008640 oboInOwl:hasDbXref "UMLS:C4024650" ; oboInOwl:id "HP:0008640" ; a owl:Class ; rdfs:label "Congenital macroorchidism" ; rdfs:subClassOf obo:HP_0000053 . obo:HP_0008643 obo:IAO_0000115 "Presence of persistent islands of renal blastema in the postnatal kidney. Nephroblastomatosis represents a complex abnormality of nephrogenesis and has been defined as the persistence of metanephricblastema into infancy and childhood." ; oboInOwl:hasDbXref "UMLS:C2675558" ; oboInOwl:id "HP:0008643" ; a owl:Class ; rdfs:label "Nephroblastomatosis" ; rdfs:subClassOf obo:HP_0011794 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_574 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008647 oboInOwl:hasDbXref "UMLS:C4024649" ; oboInOwl:id "HP:0008647" ; a owl:Class ; rdfs:label "Pubertal developmental failure in females" ; rdfs:subClassOf obo:HP_0008197 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046543 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008648 oboInOwl:hasDbXref "UMLS:C4024648" ; oboInOwl:id "HP:0008648" ; a owl:Class ; rdfs:label "Anteriorly displaced urethral meatus" ; rdfs:subClassOf obo:HP_0100627 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001921 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008651 oboInOwl:hasDbXref "UMLS:C4024647" ; oboInOwl:id "HP:0008651" ; a owl:Class ; rdfs:label "Uric acid urolithiasis independent of gout" ; rdfs:subClassOf obo:HP_0000791 . obo:HP_0008652 obo:IAO_0000115 "Impotence (inability to develop or maintain an erection) resulting from abnormal functioning of the autonomic nervous system." ; oboInOwl:hasDbXref "UMLS:C1868524" ; oboInOwl:hasExactSynonym "Impotence due to autonomic dysfunction" ; oboInOwl:id "HP:0008652" ; a owl:Class ; rdfs:label "Autonomic erectile dysfunction" ; rdfs:subClassOf obo:HP_0012332, obo:HP_0100639 . obo:HP_0008653 obo:IAO_0000115 "A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation." ; oboInOwl:hasDbXref "SNOMEDCT_US:236398000", "UMLS:C0403416" ; oboInOwl:id "HP:0008653" ; a owl:Class ; rdfs:label "Crescentic glomerulonephritis" ; rdfs:subClassOf obo:HP_0000099 . obo:HP_0008655 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the fallopian tube." ; oboInOwl:hasDbXref "UMLS:C4020791", "UMLS:C4024646" ; oboInOwl:hasExactSynonym "Absent/small fallopian tube", "Absent/underdeveloped fallopian tube" ; oboInOwl:hasRelatedSynonym "Absent or rudimentary fallopian tubes" ; oboInOwl:id "HP:0008655" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the fallopian tube" ; rdfs:subClassOf obo:HP_0011027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008656 oboInOwl:hasDbXref "UMLS:C4024645" ; oboInOwl:id "HP:0008656" ; a owl:Class ; rdfs:label "Incomplete male pseudohermaphroditism" ; rdfs:subClassOf obo:HP_0000037 . obo:HP_0008659 obo:IAO_0000115 "The presence of many cysts in the medulla of the kidney." ; oboInOwl:hasAlternativeId "HP:0005569", "HP:0100956" ; oboInOwl:hasDbXref "SNOMEDCT_US:204958008", "UMLS:C0687120", "UMLS:C4020790", "UMLS:C4024644" ; oboInOwl:hasRelatedSynonym "Medullary cystic disease", "Medullary sponge kidney disease" ; oboInOwl:id "HP:0008659" ; a owl:Class ; rdfs:comment "This feature is the cardinal sign of medullary cystic disease, also known as medullary sponge disease." ; rdfs:label "Multiple small medullary renal cysts" ; rdfs:subClassOf obo:HP_0000107, obo:HP_0100957 . obo:HP_0008660 obo:IAO_0000115 "A developmental defect characterized by absence or poor development of proximal renal tubules." ; oboInOwl:hasDbXref "MSH:C537048", "SNOMEDCT_US:702397002", "UMLS:C0266313" ; oboInOwl:hasExactSynonym "Renal tubular dysgenesis" ; oboInOwl:id "HP:0008660" ; a owl:Class ; rdfs:comment "Renotubular dysgenesis is generally accompanied by early onset and persistent oligohydramnios that leads to the Potter sequence." ; rdfs:label "Renotubular dysgenesis" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0008661 obo:IAO_0000115 "Abnormal narrowing of the urethra." ; oboInOwl:hasDbXref "MSH:D014525", "SNOMEDCT_US:236647003", "SNOMEDCT_US:76618002", "UMLS:C0041974" ; oboInOwl:hasExactSynonym "Narrowing of the urethra" ; oboInOwl:id "HP:0008661" ; a owl:Class ; rdfs:label "Urethral stenosis" ; rdfs:subClassOf obo:HP_0000796 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000057 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008663 obo:IAO_0000115 "A sarcoma of the kidney." ; oboInOwl:hasDbXref "NCIT:C3158", "SNOMEDCT_US:254918001", "UMLS:C0346251" ; oboInOwl:id "HP:0008663" ; a owl:Class ; rdfs:label "Renal sarcoma" ; rdfs:subClassOf obo:HP_0009726, obo:HP_0100242 . obo:HP_0008664 oboInOwl:hasDbXref "UMLS:C4024643" ; oboInOwl:id "HP:0008664" ; a owl:Class ; rdfs:label "Urethral sphincter sclerosis" ; rdfs:subClassOf obo:HP_0008661 . obo:HP_0008665 obo:IAO_0000115 "Hypertrophy of the clitoris." ; oboInOwl:hasAlternativeId "HP:0000057", "HP:0008728" ; oboInOwl:hasDbXref "SNOMEDCT_US:80212005", "UMLS:C0156394" ; oboInOwl:hasExactSynonym "Clitoral enlargement", "Clitoromegaly", "Enlarged clitoris", "Hypertrophic clitoris", "Prominent clitoris" ; oboInOwl:id "HP:0008665" ; a owl:Class ; rdfs:comment "Increased size of the clitoris." ; rdfs:label "Clitoral hypertrophy" ; rdfs:subClassOf obo:HP_0040253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008666 oboInOwl:hasDbXref "UMLS:C4024642" ; oboInOwl:id "HP:0008666" ; a owl:Class ; rdfs:label "Impaired histidine renal tubular absorption" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0008668 obo:IAO_0000115 "Unusual gonadal development in a person with a 46,XY male karyotype, leading to an unassigned sex differentiation." ; oboInOwl:hasDbXref "MSH:D006061", "UMLS:C0018054" ; oboInOwl:hasExactSynonym "46,xy gonadal dysgenesis" ; oboInOwl:id "HP:0008668" ; a owl:Class ; rdfs:label "Gonadal dysgenesis, male" ; rdfs:subClassOf obo:HP_0000133 . obo:HP_0008669 obo:IAO_0000115 "Incomplete maturation or aberrant formation of the male gametes." ; oboInOwl:hasDbXref "SNOMEDCT_US:4529005", "UMLS:C0520933", "UMLS:C4020789" ; oboInOwl:hasExactSynonym "Impaired spermatogenesis" ; oboInOwl:hasRelatedSynonym "Abnormal sperm development" ; oboInOwl:id "HP:0008669" ; a owl:Class ; rdfs:label "Abnormal spermatogenesis" ; rdfs:subClassOf obo:HP_0000025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007283 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008670 oboInOwl:hasDbXref "UMLS:C0750088" ; oboInOwl:id "HP:0008670" ; a owl:Class ; rdfs:label "Partial vaginal septum" ; rdfs:subClassOf obo:HP_0001153 . obo:HP_0008672 obo:IAO_0000115 "The presence of calcium- and oxalate-containing calculi (stones) in the kidneys." ; oboInOwl:hasAlternativeId "HP:0008700", "HP:0008725" ; oboInOwl:hasDbXref "MSH:C563477", "SNOMEDCT_US:444717006", "UMLS:C1833683", "UMLS:C4280806" ; oboInOwl:hasExactSynonym "Ca oxalate kidney stone", "Ca oxalate nephrolithiasis", "Ca oxalate urolithiasis", "Ca2+ oxalate kidney stone", "Ca2+ oxalate nephrolithiasis", "Ca2+ oxalate urolithiasis", "Calcium oxalate kidney stones", "Oxalate nephrolithiasis" ; oboInOwl:hasRelatedSynonym "Calcium oxalate urolithiasis" ; oboInOwl:id "HP:0008672" ; a owl:Class ; rdfs:label "Calcium oxalate nephrolithiasis" ; rdfs:subClassOf obo:HP_0004724 . obo:HP_0008675 oboInOwl:hasDbXref "UMLS:C4024641" ; oboInOwl:hasExactSynonym "Enlarged ovaries with cysts" ; oboInOwl:id "HP:0008675" ; a owl:Class ; rdfs:label "Enlarged polycystic ovaries" ; rdfs:subClassOf obo:HP_0000147, obo:HP_0100879 . obo:HP_0008676 obo:IAO_0000115 "A developmental disturbance with extreme ureteral dilatation." ; oboInOwl:hasDbXref "SNOMEDCT_US:718485003", "SNOMEDCT_US:95576001", "UMLS:C0266324" ; oboInOwl:hasExactSynonym "Congenital megaloureter" ; oboInOwl:id "HP:0008676" ; a owl:Class ; rdfs:comment "The cause of congenital megaloureter is thought to be aperistalsis of the distal ureter, leading to dilatation. The defect in peristalsis may be due to faulty development of muscle layers of ureter, that is, there is a functional, not a mechanical cause of obstruction." ; rdfs:label "Congenital megaureter" ; rdfs:subClassOf obo:HP_0000072 . obo:HP_0008677 obo:IAO_0000115 "Nephrotic syndrome with onset within the first three months of life." ; oboInOwl:hasDbXref "MSH:C535761", "SNOMEDCT_US:48796009", "UMLS:C3501848" ; oboInOwl:hasExactSynonym "Congenital nephrosis" ; oboInOwl:id "HP:0008677" ; a owl:Class ; rdfs:label "Congenital nephrotic syndrome" ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0008678 obo:IAO_0000115 "Absence or underdevelopment of the kidney." ; oboInOwl:hasAlternativeId "HP:0004744", "HP:0008701" ; oboInOwl:hasDbXref "UMLS:C1857453" ; oboInOwl:hasExactSynonym "Absent/small kidney", "Absent/underdeveloped kidney", "Renal agenesis/hypoplasia", "Renal aplasia/hypoplasia" ; oboInOwl:id "HP:0008678" ; a owl:Class ; rdfs:label "Renal hypoplasia/aplasia" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0000089 obo:HP_0000104 ) ] ] . obo:HP_0008682 obo:IAO_0000115 "Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%)." ; oboInOwl:hasDbXref "MSH:D007683", "SNOMEDCT_US:35455006", "UMLS:C0022672" ; oboInOwl:hasExactSynonym "Acute tubular necrosis", "Renal tubular necrosis" ; oboInOwl:id "HP:0008682" ; a owl:Class ; rdfs:comment "Renal tubular epithelial necrosis is a histomorphological definition that corresponds to the clinical term of acture tubular necrosis. Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases." ; rdfs:label "Renal tubular epithelial necrosis" ; rdfs:subClassOf obo:HP_0000091, obo:HP_0032618 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009773 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008683 obo:IAO_0000115 "Increase in size of the folds of skin between the outer labia." ; oboInOwl:hasAlternativeId "HP:0008662", "HP:0008694" ; oboInOwl:hasDbXref "UMLS:C1849358" ; oboInOwl:hasExactSynonym "Hypertrophic labia minora", "Labia minora hypertrophy" ; oboInOwl:id "HP:0008683" ; a owl:Class ; rdfs:label "Enlarged labia minora" ; rdfs:subClassOf obo:HP_0000065, obo:HP_0012880 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008684 obo:IAO_0000115 "Absence or developmental hypoplasia of the uterus." ; oboInOwl:hasDbXref "UMLS:C4024640" ; oboInOwl:hasExactSynonym "Absent/small uterus", "Absent/underdeveloped uterus" ; oboInOwl:id "HP:0008684" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the uterus" ; rdfs:subClassOf obo:HP_0000130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008687 oboInOwl:hasDbXref "UMLS:C1844923" ; oboInOwl:hasExactSynonym "Hypoplastic prostate", "Underdeveloped prostate" ; oboInOwl:id "HP:0008687" ; a owl:Class ; rdfs:label "Hypoplasia of the prostate" ; rdfs:subClassOf obo:HP_0008775 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008689 obo:IAO_0000115 "Absence of both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." ; oboInOwl:hasAlternativeId "HP:0008686" ; oboInOwl:hasDbXref "MSH:D003456", "SNOMEDCT_US:268228006", "UMLS:C0431663" ; oboInOwl:hasExactSynonym "Cryptorchidism, bilateral" ; oboInOwl:id "HP:0008689" ; a owl:Class ; rdfs:label "Bilateral cryptorchidism" ; rdfs:subClassOf obo:HP_0000028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000028 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0008691 obo:IAO_0000115 "Presence of a single diverticulum (sac or pouch) in the wall of the urinary bladder." ; oboInOwl:hasDbXref "UMLS:C4024639" ; oboInOwl:id "HP:0008691" ; a owl:Class ; rdfs:label "Solitary bladder diverticulum" ; rdfs:subClassOf obo:HP_0000015 . obo:HP_0008694 obo:IAO_0100001 "HP:0008683" ; oboInOwl:id "HP:0008694" ; a owl:Class ; rdfs:label "obsolete Hypertrophic labia minora" ; owl:deprecated true . obo:HP_0008695 oboInOwl:hasDbXref "UMLS:C4024638" ; oboInOwl:hasExactSynonym "Transient nephrosis" ; oboInOwl:id "HP:0008695" ; a owl:Class ; rdfs:label "Transient nephrotic syndrome" ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0008696 obo:IAO_0000115 "A disordered proliferation of mature tissues that are native to the kidneys." ; oboInOwl:hasDbXref "UMLS:C1840396" ; oboInOwl:id "HP:0008696" ; a owl:Class ; rdfs:label "Renal hamartoma" ; rdfs:subClassOf obo:HP_0009726, obo:HP_0010566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008697 obo:IAO_0000115 "Developmental hypoplasia of the fallopian tube." ; oboInOwl:hasDbXref "UMLS:C1968706" ; oboInOwl:hasExactSynonym "Underdeveloped fallopian tube" ; oboInOwl:hasRelatedSynonym "Rudimentary fallopian tubes" ; oboInOwl:id "HP:0008697" ; a owl:Class ; rdfs:label "Hypoplasia of the fallopian tube" ; rdfs:subClassOf obo:HP_0008655 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008702 oboInOwl:hasDbXref "UMLS:C4024637" ; oboInOwl:id "HP:0008702" ; a owl:Class ; rdfs:label "Absent internal genitalia" ; rdfs:subClassOf obo:HP_0000812 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004175 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008703 obo:IAO_0000115 "Deposition of calcium salts in gonadal tissue." ; oboInOwl:hasDbXref "UMLS:C4024636" ; oboInOwl:id "HP:0008703" ; a owl:Class ; rdfs:label "Gonadal calcification" ; rdfs:subClassOf obo:HP_0000812, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000991 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008705 oboInOwl:hasDbXref "UMLS:C4024635" ; oboInOwl:id "HP:0008705" ; a owl:Class ; rdfs:label "Ureteral triplication" ; rdfs:subClassOf obo:HP_0000073 . obo:HP_0008706 oboInOwl:hasDbXref "UMLS:C4024634" ; oboInOwl:id "HP:0008706" ; a owl:Class ; rdfs:label "Distal urethral duplication" ; rdfs:subClassOf obo:HP_0000795 . obo:HP_0008707 obo:IAO_0000115 "Congenital absence of the scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:249233008", "UMLS:C0426320" ; oboInOwl:hasExactSynonym "Absent scrotum" ; oboInOwl:id "HP:0008707" ; a owl:Class ; rdfs:comment "Both the sac and rugae are absent. This finding may be accompanied by an (Apparently) absent testis and Cryptorchidism, which should be coded separately." ; rdfs:label "Absent scrotum" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0008708 oboInOwl:hasDbXref "UMLS:C1837379" ; oboInOwl:id "HP:0008708" ; a owl:Class ; rdfs:label "Partial development of the penile shaft" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0008711 obo:IAO_0000115 "The presence of non-malignant hyperplasia of the prostate." ; oboInOwl:hasDbXref "MSH:D011470", "SNOMEDCT_US:266569009", "UMLS:C0005001", "UMLS:C1704272" ; oboInOwl:hasExactSynonym "Benign prostatic hypertrophy" ; oboInOwl:id "HP:0008711" ; a owl:Class ; rdfs:label "Benign prostatic hyperplasia" ; rdfs:subClassOf obo:HP_0008775 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008714 oboInOwl:hasDbXref "UMLS:C4024633" ; oboInOwl:id "HP:0008714" ; a owl:Class ; rdfs:label "Ureterovesical stenosis" ; rdfs:subClassOf obo:HP_0000071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009973 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008715 oboInOwl:hasDbXref "SNOMEDCT_US:253847002", "UMLS:C0302885" ; oboInOwl:id "HP:0008715" ; a owl:Class ; rdfs:label "Testicular dysgenesis" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008716 obo:IAO_0000115 "The presence of a fistula between the vagina and the urethra." ; oboInOwl:hasDbXref "SNOMEDCT_US:50477003", "UMLS:C0269133" ; oboInOwl:hasExactSynonym "Urethrovaginal fistulae" ; oboInOwl:id "HP:0008716" ; a owl:Class ; rdfs:label "Urethrovaginal fistula" ; rdfs:subClassOf obo:HP_0004320, obo:HP_0010480 . obo:HP_0008717 obo:IAO_0000115 "A unilateral form of atrophy of the kidney." ; oboInOwl:hasDbXref "SNOMEDCT_US:424998002", "UMLS:C1827184" ; oboInOwl:hasExactSynonym "Kidney degeneration on one side", "Unilateral kidney wasting" ; oboInOwl:id "HP:0008717" ; a owl:Class ; rdfs:label "Unilateral renal atrophy" ; rdfs:subClassOf obo:HP_0012585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0008718 obo:IAO_0000115 "A unilateral form of developmental dysplasia of the kidney." ; oboInOwl:hasDbXref "SNOMEDCT_US:204951002", "UMLS:C0431697" ; oboInOwl:id "HP:0008718" ; a owl:Class ; rdfs:label "Unilateral renal dysplasia" ; rdfs:subClassOf obo:HP_0000110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0008720 oboInOwl:hasDbXref "SNOMEDCT_US:370997001", "SNOMEDCT_US:48723006", "UMLS:C1384582" ; oboInOwl:id "HP:0008720" ; a owl:Class ; rdfs:label "Primary testicular failure" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0008722 obo:IAO_0000115 "The presence of a diverticulum (sac or pouch) in the wall of the urethra." ; oboInOwl:hasDbXref "SNOMEDCT_US:90531003", "UMLS:C0152443" ; oboInOwl:id "HP:0008722" ; a owl:Class ; rdfs:label "Urethral diverticulum" ; rdfs:subClassOf obo:HP_0000795 . obo:HP_0008723 obo:IAO_0000115 "Unusual gonadal development in a person with a 46,XY male karyotype, leading to a more female sex differentiation." ; oboInOwl:hasDbXref "UMLS:C4020788", "UMLS:C4024632" ; oboInOwl:hasRelatedSynonym "Xy female gonadal dysgenesis" ; oboInOwl:id "HP:0008723" ; a owl:Class ; rdfs:comment "Very bad term - try to get rid of it later." ; rdfs:label "Gonadal dysgenesis with female appearance, male" ; rdfs:subClassOf obo:HP_0000133 . obo:HP_0008724 obo:IAO_0000115 "Developmental hypoplasia of the ovary." ; oboInOwl:hasDbXref "SNOMEDCT_US:93279005", "UMLS:C0685840", "UMLS:C1835452" ; oboInOwl:hasExactSynonym "Underdeveloped ovary" ; oboInOwl:hasRelatedSynonym "Hypoplastic ovary" ; oboInOwl:id "HP:0008724" ; a owl:Class ; rdfs:label "Hypoplasia of the ovary" ; rdfs:subClassOf obo:HP_0010462 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008726 obo:IAO_0000115 "Developmental hypoplasia of the vagina." ; oboInOwl:hasAlternativeId "HP:0011938" ; oboInOwl:hasDbXref "SNOMEDCT_US:253836009", "UMLS:C0345309", "UMLS:C1442988" ; oboInOwl:hasExactSynonym "Rudimentary vagina", "Underdeveloped vagina" ; oboInOwl:hasRelatedSynonym "Hypoplastic vagina" ; oboInOwl:id "HP:0008726" ; a owl:Class ; rdfs:label "Hypoplasia of the vagina" ; rdfs:subClassOf obo:HP_0011026 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008729 oboInOwl:hasDbXref "UMLS:C1849575" ; oboInOwl:hasExactSynonym "Absent vaginal lips" ; oboInOwl:id "HP:0008729" ; a owl:Class ; rdfs:label "Absence of labia majora" ; rdfs:subClassOf obo:HP_0012881 . obo:HP_0008730 obo:IAO_0000115 "The presence of female external genitalia in a person with a male karyotype." ; oboInOwl:hasAlternativeId "HP:0008719" ; oboInOwl:hasDbXref "UMLS:C1848178" ; oboInOwl:hasExactSynonym "Males with female external genitalia" ; oboInOwl:id "HP:0008730" ; a owl:Class ; rdfs:label "Female external genitalia in individual with 46,XY karyotype" ; rdfs:subClassOf obo:HP_0000032 . obo:HP_0008732 obo:IAO_0000115 "Renal hypophosphatemia is defined as reduced serum phosphate (e.g., below 0.70 mmol/l) and an inappropriately high renal phosphate excretion." ; oboInOwl:hasDbXref "UMLS:C4024631" ; oboInOwl:id "HP:0008732" ; a owl:Class ; rdfs:comment "Three primary mechanisms of hypophosphatemia exist: increased renal excretion, decreased intestinal absorption, and movement of phosphate from the extracellular to intracellular compartments. The initial step in diagnosis involves determining whether hypophosphatemia is renal or nonrenal." ; rdfs:label "Renal hypophosphatemia" ; rdfs:subClassOf obo:HP_0002148 . obo:HP_0008733 oboInOwl:hasDbXref "UMLS:C1837380" ; oboInOwl:id "HP:0008733" ; a owl:Class ; rdfs:label "Dysplastic testes" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0008734 obo:IAO_0000115 "Reduced volume of the testicle (the male gonad)." ; oboInOwl:hasAlternativeId "HP:0000043" ; oboInOwl:hasDbXref "SNOMEDCT_US:276411001", "UMLS:C0241355" ; oboInOwl:hasExactSynonym "Decreased testicular size", "Hypoplastic testes", "Small testes", "Small testis", "Testicular hypoplasia" ; oboInOwl:id "HP:0008734" ; a owl:Class ; rdfs:label "Decreased testicular size" ; rdfs:subClassOf obo:HP_0000050, obo:HP_0010468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008736 oboInOwl:hasAlternativeId "HP:0008632" ; oboInOwl:hasDbXref "SNOMEDCT_US:34911001", "UMLS:C0266435" ; oboInOwl:hasExactSynonym "Underdeveloped penis" ; oboInOwl:id "HP:0008736" ; a owl:Class ; rdfs:label "Hypoplasia of penis" ; rdfs:subClassOf obo:HP_0000036, obo:HP_0000050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008738 obo:IAO_0000115 "The presence of a partially duplicated kidney." ; oboInOwl:hasDbXref "UMLS:C4024630" ; oboInOwl:hasExactSynonym "Partially duplicated kidney" ; oboInOwl:id "HP:0008738" ; a owl:Class ; rdfs:label "Partially duplicated kidney" ; rdfs:subClassOf obo:HP_0000075 . obo:HP_0008739 oboInOwl:hasDbXref "UMLS:C1835380" ; oboInOwl:id "HP:0008739" ; a owl:Class ; rdfs:label "Labial pseudohypertrophy" ; rdfs:subClassOf obo:HP_0000065 . obo:HP_0008740 obo:IAO_0000115 "The presence of a longitudinal vaginal septum, thereby creating a vaginal duplication." ; oboInOwl:hasAlternativeId "HP:0008698" ; oboInOwl:hasDbXref "UMLS:C1841680" ; oboInOwl:hasExactSynonym "Vertical vaginal septum" ; oboInOwl:id "HP:0008740" ; a owl:Class ; rdfs:label "Longitudinal vaginal septum" ; rdfs:subClassOf obo:HP_0001153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001854 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008742 oboInOwl:hasDbXref "UMLS:C4024629" ; oboInOwl:id "HP:0008742" ; a owl:Class ; rdfs:label "Prominent prostate median bar" ; rdfs:subClassOf obo:HP_0008775 . obo:HP_0008743 obo:IAO_0000115 "A mild form of hypospadias in which the urethra opens just under the corona glandis." ; oboInOwl:hasDbXref "SNOMEDCT_US:429641000124109", "UMLS:C1394030", "UMLS:C4020787" ; oboInOwl:hasRelatedSynonym "Subcoronal hypospadias" ; oboInOwl:id "HP:0008743" ; a owl:Class ; rdfs:label "Coronal hypospadias" ; rdfs:subClassOf obo:HP_0000047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0016408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008744 obo:IAO_0000115 "An abnormality of the aryepiglottic fold." ; oboInOwl:hasDbXref "UMLS:C1849357" ; oboInOwl:hasExactSynonym "Abnormal aryepiglottic folds", "Abnormality of the aryepiglottic fold" ; oboInOwl:id "HP:0008744" ; a owl:Class ; rdfs:comment "The aryepiglottic fold is a fold of mucous membrane extending on each side between the lateral border of the epiglottis and the summit of the arytenoid cartilage." ; rdfs:label "Abnormal aryepiglottic fold morphology" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008747 obo:IAO_0000115 "Ossification affecting the set of cartilages of larynx." ; oboInOwl:hasDbXref "UMLS:C1855622" ; oboInOwl:id "HP:0008747" ; a owl:Class ; rdfs:comment "This term describes abnormal ossification affecting one or more of the cartilages of the larnyx (cricoid cartilage, thyroid cartilage, epiglottic cartilage, arytenoid cartilage, corniculate cartilage, cuneiform cartilage, triticeal cartilage, and sesamoid cartilage)." ; rdfs:label "Cartilaginous ossification of larynx" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001739 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008749 obo:IAO_0000115 "Underdevelopment of the larynx." ; oboInOwl:hasAlternativeId "HP:0005935" ; oboInOwl:hasDbXref "SNOMEDCT_US:253736003", "UMLS:C0431527" ; oboInOwl:hasExactSynonym "Hypoplastic larynx" ; oboInOwl:id "HP:0008749" ; a owl:Class ; rdfs:label "Laryngeal hypoplasia" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008750 obo:IAO_0000115 "Congenital absence of the lumen of the larynx. Laryngeal atresia is a rare condition. If the laryngeal opening fails to develop, fluid secreted by the lungs cannot be expelled. In a fetus with laryngeal atresia, the lungs are either normal or hyperplastic, not hypoplastic. Mortality is reported as 100%. At obstetric US examination, views of the fetal neck demonstrate a dilated trachea filled with trapped fluid. Views of the fetal chest show enlarged, hyperechoic lungs, with dilated fluid-filled bronchi. Fetal ascites is usually present." ; oboInOwl:hasDbXref "SNOMEDCT_US:64981002", "UMLS:C0265756" ; oboInOwl:id "HP:0008750" ; a owl:Class ; rdfs:comment "Laryngeal atresia results from failure of recanalization of the laryngotracheal tube during the third month of gestation. Laryngeal atresia manifests as acute airway obstruction in the newborn immediately following clamping of the umbilical cord and is fatal without immediate airway management with a tracheotomy. Congenital laryngeal atresia is a rare anomaly that is mostly incompatible with life. Most authors claim that this malformation is related to an arrest of the sixth brachial arch at different gestational stages during normal embryologic development. Complete laryngeal atresia results in a desperate emergency during the first few moments of life, and surgical intervention must occur within 2 to 5 minutes of birth to enable respiration. The most dramatic physical finding is that the child is aphonic, with absence of any cry or gasp at birth." ; rdfs:label "Laryngeal atresia" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008751 obo:IAO_0000115 "Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esophagus." ; oboInOwl:hasDbXref "MSH:C537875", "SNOMEDCT_US:232461002", "UMLS:C1840311" ; oboInOwl:hasExactSynonym "Laryngotracheal cleft", "Laryngotracheoesophageal cleft i" ; oboInOwl:id "HP:0008751" ; a owl:Class ; rdfs:comment "Embryologically, the trachea and esophagus share a common lumen until they are separated by the development of the tracheoesophageal septum. Failure of this fusion and incomplete development of the tracheoesophageal septum may lead to congenital abnormalities such as isolatedlaryngeal cleft, tracheoesophageal fistula, and esophageal atresia, depending on the severity of the abnormality. Patients with laryngeal cleft may present with feeding difficulty, chronic cough, stridor, pneumonia or respiratory distress, depending on the size of the cleft." ; rdfs:label "Laryngeal cleft" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008752 obo:IAO_0000115 "A malformation of the laryngeal cartilage." ; oboInOwl:hasAlternativeId "HP:0008375" ; oboInOwl:hasDbXref "UMLS:C4021530" ; oboInOwl:hasExactSynonym "Vocal impairment, severe, due to laryngeal cartilage abnormalities" ; oboInOwl:id "HP:0008752" ; a owl:Class ; rdfs:label "Laryngeal cartilage malformation" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008753 obo:IAO_0000115 "Absence of the epiglottis." ; oboInOwl:hasDbXref "UMLS:C4024628" ; oboInOwl:hasExactSynonym "Absent epiglottis" ; oboInOwl:id "HP:0008753" ; a owl:Class ; rdfs:label "Aplasia of the epiglottis" ; rdfs:subClassOf obo:HP_0010565 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008754 obo:IAO_0000115 "Calcification (abnormal deposits of calcium) in the laryngeal tissues." ; oboInOwl:hasAlternativeId "HP:0008748" ; oboInOwl:hasDbXref "UMLS:C1859158" ; oboInOwl:hasExactSynonym "Laryngeal calcifications" ; oboInOwl:id "HP:0008754" ; a owl:Class ; rdfs:label "Laryngeal calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008755 oboInOwl:hasDbXref "SNOMEDCT_US:308232009", "UMLS:C0585984" ; oboInOwl:id "HP:0008755" ; a owl:Class ; rdfs:label "Laryngotracheomalacia" ; rdfs:subClassOf obo:HP_0002779 . obo:HP_0008756 obo:IAO_0000115 "Bowing (abnormal curvature) of the vocal folds." ; oboInOwl:hasDbXref "SNOMEDCT_US:232448002", "UMLS:C0396064" ; oboInOwl:id "HP:0008756" ; a owl:Class ; rdfs:label "Bowing of the vocal cords" ; rdfs:subClassOf obo:HP_0008777 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008757 obo:IAO_0000115 "A loss of the ability to move the vocal fold on one side." ; oboInOwl:hasDbXref "MSH:D014826", "UMLS:C0751575" ; oboInOwl:hasExactSynonym "Unilateral paralysis of the vocal cord" ; oboInOwl:id "HP:0008757" ; a owl:Class ; rdfs:label "Unilateral vocal cord paralysis" ; rdfs:subClassOf obo:HP_0001605 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0008760 oboInOwl:hasDbXref "SNOMEDCT_US:248004009", "UMLS:C0424323" ; oboInOwl:hasExactSynonym "Violent behavior", "Violent behaviour" ; oboInOwl:id "HP:0008760" ; a owl:Class ; rdfs:label "Violent behavior" ; rdfs:subClassOf obo:HP_0006919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008762 oboInOwl:hasDbXref "UMLS:C1969697" ; oboInOwl:hasExactSynonym "Repetitive compulsive behavior", "Repetitive compulsive behaviour" ; oboInOwl:id "HP:0008762" ; a owl:Class ; rdfs:label "Repetitive compulsive behavior" ; rdfs:subClassOf obo:HP_0000733 . obo:HP_0008763 oboInOwl:hasDbXref "UMLS:C1849683" ; oboInOwl:hasExactSynonym "No social interaction" ; oboInOwl:id "HP:0008763" ; a owl:Class ; rdfs:label "No social interaction" ; rdfs:subClassOf obo:HP_0000735 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008765 obo:IAO_0000115 "The false perception of sound." ; oboInOwl:hasAlternativeId "HP:0000714" ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:45150006", "UMLS:C0233762" ; oboInOwl:hasExactSynonym "Hallucinations of sound", "Hearing sounds" ; oboInOwl:id "HP:0008765" ; a owl:Class ; rdfs:label "Auditory hallucinations" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0008767 oboInOwl:hasDbXref "UMLS:C1860219" ; oboInOwl:hasExactSynonym "Self-mutilation of tongue and lips due to involuntary movements" ; oboInOwl:id "HP:0008767" ; a owl:Class ; rdfs:label "Self-mutilation of tongue and lips due to involuntary movements" ; rdfs:subClassOf obo:HP_0000742, obo:HP_0004305 . obo:HP_0008768 oboInOwl:hasDbXref "SNOMEDCT_US:248099006", "UMLS:C0474420" ; oboInOwl:hasExactSynonym "Inappropriate sexual behavior", "Inappropriate sexual behaviour" ; oboInOwl:id "HP:0008768" ; a owl:Class ; rdfs:label "Inappropriate sexual behavior" ; rdfs:subClassOf obo:HP_0000719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008770 obo:IAO_0000115 "The presence of one or more obsessive-compulsive personality traits. Obsessions refer to persistent intrusive thoughts, and compulsions to intrusive behaviors, which the affected person experiences as involuntary, senseless, or repugnant." ; oboInOwl:hasAlternativeId "HP:0008761" ; oboInOwl:hasDbXref "UMLS:C1834433" ; oboInOwl:hasExactSynonym "Obsessive-compulsive trait", "Obsessive-compulsive traits" ; oboInOwl:id "HP:0008770" ; a owl:Class ; rdfs:label "Obsessive-compulsive trait" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_0008771 obo:IAO_0000115 "The presence of aplasia or developmental hypoplasia of the ear." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T05:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4024627" ; oboInOwl:hasExactSynonym "Absent/small ear", "Absent/underdeveloped ear" ; oboInOwl:id "HP:0008771" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the ear" ; rdfs:subClassOf obo:HP_0031703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008772 obo:IAO_0000115 "The presence of aplasia or developmental hypoplasia of all or part of the external ear." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T05:45:00Z" ; oboInOwl:hasDbXref "UMLS:C4024626" ; oboInOwl:hasExactSynonym "Absent/small external ear", "Absent/underdeveloped external ear" ; oboInOwl:id "HP:0008772" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the external ear" ; rdfs:subClassOf obo:HP_0000377, obo:HP_0008771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008773 obo:IAO_0000115 "Aplasia or developmental hypoplasia of all or part of the middle ear." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T05:47:00Z" ; oboInOwl:hasAlternativeId "HP:0008533", "HP:0008548" ; oboInOwl:hasDbXref "UMLS:C4021529" ; oboInOwl:hasExactSynonym "Absent/small middle ear", "Absent/underdeveloped middle ear", "Hypoplastic/aplastic middle ear structures", "Middle ear hypoplasia/aplasia" ; oboInOwl:id "HP:0008773" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle ear" ; rdfs:subClassOf obo:HP_0008609, obo:HP_0008771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008774 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T05:48:00Z" ; oboInOwl:hasDbXref "UMLS:C4024625" ; oboInOwl:hasExactSynonym "Absent/small inner ear", "Absent/underdeveloped inner ear" ; oboInOwl:id "HP:0008774" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the inner ear" ; rdfs:subClassOf obo:HP_0008771, obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001846 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008775 obo:IAO_0000115 "An abnormality of the prostate." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T06:01:00Z" ; oboInOwl:hasDbXref "UMLS:C0747987" ; oboInOwl:hasExactSynonym "Abnormality of the prostate" ; oboInOwl:id "HP:0008775" ; a owl:Class ; rdfs:label "Abnormal prostate morphology" ; rdfs:subClassOf obo:HP_0000022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008776 obo:IAO_0000115 "Any structural abnormality of the renal artery." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T06:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4024624" ; oboInOwl:hasExactSynonym "Abnormal kidney artery", "Abnormality of the renal artery" ; oboInOwl:id "HP:0008776" ; a owl:Class ; rdfs:label "Abnormal renal artery morphology" ; rdfs:subClassOf obo:HP_0011004, obo:HP_0033836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001184 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008777 obo:IAO_0000115 "An abnormality of the vocal cord." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T06:18:00Z" ; oboInOwl:hasDbXref "UMLS:C0262665" ; oboInOwl:hasExactSynonym "Abnormality of the vocal cords" ; oboInOwl:id "HP:0008777" ; a owl:Class ; rdfs:comment "The vocal cords, also known as the vocal folds, represent a subdivision of the larynx, and consist of twin infoldings of mucous membrane stretched horizontally across the larynx." ; rdfs:label "Abnormal vocal cord morphology" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008780 oboInOwl:hasDbXref "SNOMEDCT_US:10155006", "UMLS:C0158713" ; oboInOwl:id "HP:0008780" ; a owl:Class ; rdfs:label "Congenital bilateral hip dislocation" ; rdfs:subClassOf obo:HP_0001374 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0008783 obo:IAO_0000115 "Increased width of the proximal part of the shaft (metaphysis) of the femur." ; oboInOwl:hasAlternativeId "HP:0008790" ; oboInOwl:hasDbXref "UMLS:C4024623" ; oboInOwl:hasExactSynonym "Wide metaphysis of innermost thighbone" ; oboInOwl:id "HP:0008783" ; a owl:Class ; rdfs:label "Wide proximal femoral metaphysis" ; rdfs:subClassOf obo:HP_0006417, obo:HP_0006431 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008784 obo:IAO_0000115 "Abnormally wide morphology of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C4024622" ; oboInOwl:hasExactSynonym "Wide end part of innermost thighbone" ; oboInOwl:id "HP:0008784" ; a owl:Class ; rdfs:label "Wide capital femoral epiphyses" ; rdfs:subClassOf obo:HP_0010574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008785 obo:IAO_0000115 "Delayed maturation and calcification of the rami (branches) of the pubic bone." ; oboInOwl:hasDbXref "UMLS:C1865363" ; oboInOwl:id "HP:0008785" ; a owl:Class ; rdfs:label "Delayed ossification of pubic rami" ; rdfs:subClassOf obo:HP_0009105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0014444 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008786 obo:IAO_0000115 "Irregularities of the iliac crest that produce the appearance of a lace border around it." ; oboInOwl:hasAlternativeId "HP:0008825" ; oboInOwl:hasDbXref "UMLS:C1857186" ; oboInOwl:hasExactSynonym "Irregular lacy iliac crest", "Lacy appearance of iliac crest" ; oboInOwl:id "HP:0008786" ; a owl:Class ; rdfs:label "Iliac crest serration" ; rdfs:subClassOf obo:HP_0003796 . obo:HP_0008788 obo:IAO_0000115 "Delayed maturation and calcification of the pubic bone." ; oboInOwl:hasAlternativeId "HP:0008795", "HP:0008827" ; oboInOwl:hasDbXref "UMLS:C1861528", "UMLS:C1866710", "UMLS:C4280411" ; oboInOwl:hasExactSynonym "Absent pubic ossification in infancy" ; oboInOwl:hasRelatedSynonym "Delayed maturation fo pubic bone", "Delayed mineralization of pubic bone" ; oboInOwl:id "HP:0008788" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Delayed pubic bone ossification" ; rdfs:subClassOf obo:HP_0009105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001275 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008789 obo:IAO_0000115 "A cone-shaped deformity of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1846157" ; oboInOwl:hasExactSynonym "Cone-shaped end part of innermost thighbone" ; oboInOwl:id "HP:0008789" ; a owl:Class ; rdfs:label "Cone-shaped capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0010574, obo:HP_0010579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008794 obo:IAO_0000115 "A general term that describes a congenital defect in the iliac wing resulting from abnormal development." ; oboInOwl:hasDbXref "UMLS:C1837487" ; oboInOwl:hasExactSynonym "Dysplastic iliac wings" ; oboInOwl:id "HP:0008794" ; a owl:Class ; rdfs:label "Dysplastic iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008796 obo:IAO_0000115 "An abnormal backward rotation of the hip relative to the knee such that the hips are externally rotated with the foot pointed outward instead of straight ahead (out-toeing)." ; oboInOwl:hasAlternativeId "HP:0003783" ; oboInOwl:hasDbXref "UMLS:C1846339" ; oboInOwl:hasExactSynonym "Decreased femoral torsion", "Externally rotated hips" ; oboInOwl:id "HP:0008796" ; a owl:Class ; rdfs:comment "Femoral torsion, also known as femoral rotation or femoral version, refers to the twist between the proximal and distal parts of the femur on the transverse plane. Femoral anteversion averages between 30-40 degress at birth, and between 8-14 degrees in adults. This term applies if the amount of femoral torsion is below this range." ; rdfs:label "Femoral retroversion" ; rdfs:subClassOf obo:HP_0031069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002156 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008797 obo:IAO_0000115 "Developmental acceleration of ossification of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C4024621" ; oboInOwl:id "HP:0008797" ; a owl:Class ; rdfs:label "Early ossification of capital femoral epiphyses" ; rdfs:subClassOf obo:HP_0009107, obo:HP_0010574, obo:HP_0010656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008798 obo:IAO_0000115 "The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a increase in the lateral dimension of the notch." ; oboInOwl:hasAlternativeId "HP:0010457" ; oboInOwl:hasDbXref "UMLS:C4024620" ; oboInOwl:hasExactSynonym "Widened sacrosciatic notch", "Widening of the sacrosciatic notch" ; oboInOwl:id "HP:0008798" ; a owl:Class ; rdfs:label "Widened greater sciatic notch" ; rdfs:subClassOf obo:HP_0010456 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008800 obo:IAO_0000115 "A decreased ability to move the femur at the hip joint associated with a decreased range of motion of the hip." ; oboInOwl:hasDbXref "UMLS:C1851542" ; oboInOwl:hasExactSynonym "Limited hip movement" ; oboInOwl:id "HP:0008800" ; a owl:Class ; rdfs:label "Limited hip movement" ; rdfs:subClassOf obo:HP_0001376 . obo:HP_0008801 obo:IAO_0000115 "Underdevelopment of the lesser trochanter." ; oboInOwl:hasDbXref "UMLS:C1840062" ; oboInOwl:hasExactSynonym "Lesser trochanter hypoplasia" ; oboInOwl:id "HP:0008801" ; a owl:Class ; rdfs:label "Hypoplasia of the lesser trochanter" ; rdfs:subClassOf obo:HP_0003366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008802 obo:IAO_0000115 "Underdevelopment of the femoral head." ; oboInOwl:hasAlternativeId "HP:0008831" ; oboInOwl:hasDbXref "UMLS:C1856920" ; oboInOwl:hasExactSynonym "Hypoplastic femoral head", "Small femoral heads", "Small head of thigh bone" ; oboInOwl:id "HP:0008802" ; a owl:Class ; rdfs:label "Hypoplasia of the femoral head" ; rdfs:subClassOf obo:HP_0003368, obo:HP_0009108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008803 obo:IAO_0100001 "HP:0003375" ; oboInOwl:id "HP:0008803" ; a owl:Class ; rdfs:label "obsolete Narrow sacroiliac notch" ; owl:deprecated true . obo:HP_0008804 obo:IAO_0000115 "Increased width of the femoral head." ; oboInOwl:hasDbXref "UMLS:C4024619" ; oboInOwl:hasExactSynonym "Wide head of thigh bone" ; oboInOwl:id "HP:0008804" ; a owl:Class ; rdfs:label "Broad femoral head" ; rdfs:subClassOf obo:HP_0003368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002359 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008807 obo:IAO_0000115 "A smaller than normal acetabulum that has insufficient femoral head coverage leading to abnormal hip joint contact pressures, instability and pain." ; oboInOwl:hasAlternativeId "HP:0008799" ; oboInOwl:hasDbXref "MSH:D006617", "UMLS:C1328407" ; oboInOwl:hasExactSynonym "Dysplastic acetabulae" ; oboInOwl:id "HP:0008807" ; a owl:Class ; rdfs:comment "Acetabular dysplasia can lead to hip pain and early-onset hip osteoarthritis." ; rdfs:label "Acetabular dysplasia" ; rdfs:subClassOf obo:HP_0003170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001269 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008808 obo:IAO_0000115 "Increased height of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally)." ; oboInOwl:hasAlternativeId "HP:0008778" ; oboInOwl:hasDbXref "UMLS:C1969680" ; oboInOwl:hasExactSynonym "High iliac wings", "Narrow, high iliac wings" ; oboInOwl:id "HP:0008808" ; a owl:Class ; rdfs:label "High iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008812 obo:IAO_0000115 "An abnormally flattened femoral head." ; oboInOwl:hasDbXref "UMLS:C1860601" ; oboInOwl:hasExactSynonym "Flat head of thigh bone" ; oboInOwl:hasRelatedSynonym "Flattened femoral heads" ; oboInOwl:id "HP:0008812" ; a owl:Class ; rdfs:label "Flattened femoral head" ; rdfs:subClassOf obo:HP_0003368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008817 obo:IAO_0000115 "A developmental defect characterized by lack of development of the pubis bone." ; oboInOwl:hasDbXref "UMLS:C1848660" ; oboInOwl:hasExactSynonym "Absent pubic bones", "Aplastic pubic bones" ; oboInOwl:id "HP:0008817" ; a owl:Class ; rdfs:label "Aplastic pubic bone" ; rdfs:subClassOf obo:HP_0009104 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008818 obo:IAO_0000115 "Increased size of the ilium ala." ; oboInOwl:hasDbXref "UMLS:C4024618" ; oboInOwl:hasExactSynonym "Large iliac wings" ; oboInOwl:id "HP:0008818" ; a owl:Class ; rdfs:label "Large iliac wing" ; rdfs:subClassOf obo:HP_0011867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008819 obo:IAO_0000115 "An abnormally reduced diameter of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." ; oboInOwl:hasDbXref "UMLS:C1863739" ; oboInOwl:hasExactSynonym "Narrow neck of thigh bone" ; oboInOwl:hasRelatedSynonym "Narrow femoral necks" ; oboInOwl:id "HP:0008819" ; a owl:Class ; rdfs:label "Narrow femoral neck" ; rdfs:subClassOf obo:HP_0003367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008820 obo:IAO_0000115 "Lack of ossification of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1968686" ; oboInOwl:hasExactSynonym "Absent ossification of femoral capital epiphyses" ; oboInOwl:id "HP:0008820" ; a owl:Class ; rdfs:comment "The ossification center of the capital femoral epiphysis appears at the end of the first year after birth." ; rdfs:label "Absent ossification of capital femoral epiphysis" ; rdfs:subClassOf obo:HP_0005003, obo:HP_0009107, obo:HP_0010656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004411 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008821 oboInOwl:hasDbXref "UMLS:C1837078" ; oboInOwl:id "HP:0008821" ; a owl:Class ; rdfs:label "Hypoplastic inferior ilia" ; rdfs:subClassOf obo:HP_0000946 . obo:HP_0008822 obo:IAO_0000115 "Underdevelopment of the ischiopubic ramus, which is comprised of the inferior pubic ramus and the inferior ramus of the ischium." ; oboInOwl:hasDbXref "UMLS:C4024617" ; oboInOwl:hasExactSynonym "Hypoplastic ischiopubic rami" ; oboInOwl:id "HP:0008822" ; a owl:Class ; rdfs:label "Hypoplastic ischiopubic ramus" ; rdfs:subClassOf obo:HP_0003173, obo:HP_0003175 . obo:HP_0008823 obo:IAO_0000115 "Underdevelopment of the lower branch of the pubis bone (inferior pubic ramus)." ; oboInOwl:hasDbXref "UMLS:C1853573" ; oboInOwl:hasExactSynonym "Hypoplastic inferior pubic rami" ; oboInOwl:id "HP:0008823" ; a owl:Class ; rdfs:comment "The pubis is the anterior part of the hip bone and forms the anterior and inferior borders of the obturator foramen (the obturator foramen is the opening between the ischium and pubic bones). It is divisible into a body, a superior and an inferior ramus." ; rdfs:label "Inferior pubic ramus hypoplasia" ; rdfs:subClassOf obo:HP_0008830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014439 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008824 obo:IAO_0000115 "Underdevelopment of the body of ilium." ; oboInOwl:hasAlternativeId "HP:0005740" ; oboInOwl:hasDbXref "UMLS:C1849034" ; oboInOwl:hasExactSynonym "Hypoplastic iliac bodies", "Small iliac bodies" ; oboInOwl:id "HP:0008824" ; a owl:Class ; rdfs:label "Hypoplastic iliac body" ; rdfs:subClassOf obo:HP_0000946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010747 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008826 obo:IAO_0000115 "Joint dislocation of the femoral head." ; oboInOwl:hasDbXref "UMLS:C1859446" ; oboInOwl:hasExactSynonym "Dislocated femoral heads", "Dislocated head of thigh bone" ; oboInOwl:id "HP:0008826" ; a owl:Class ; rdfs:label "Dislocation of the femoral head" ; rdfs:subClassOf obo:HP_0003368, obo:HP_0030311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001852 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008828 obo:IAO_0000115 "Developmental delay of ossification of the proximal epiphysis of the femur." ; oboInOwl:hasDbXref "UMLS:C1855222" ; oboInOwl:hasExactSynonym "Delayed ossification of the proximal femoral epiphysis", "Delayed ossification proximal femoral epiphyses" ; oboInOwl:id "HP:0008828" ; a owl:Class ; rdfs:comment "The proximal femoral epiphyseal ossification center normally appears at about age 6 months." ; rdfs:label "Delayed proximal femoral epiphyseal ossification" ; rdfs:subClassOf obo:HP_0002663, obo:HP_0009107, obo:HP_0010574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008829 obo:IAO_0000115 "Delayed ossification of the femoral head." ; oboInOwl:hasDbXref "UMLS:C1846446", "UMLS:C4280410" ; oboInOwl:hasRelatedSynonym "Delayed maturation of the head of the thigh bone" ; oboInOwl:id "HP:0008829" ; a owl:Class ; rdfs:label "Delayed femoral head ossification" ; rdfs:subClassOf obo:HP_0003368, obo:HP_0009107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0006767 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008830 obo:IAO_0000115 "Underdevelopment of a ramus (branch) of the pubic bone." ; oboInOwl:hasDbXref "UMLS:C1969176" ; oboInOwl:hasExactSynonym "Hypoplastic pubic rami" ; oboInOwl:id "HP:0008830" ; a owl:Class ; rdfs:label "Hypoplastic pubic ramus" ; rdfs:subClassOf obo:HP_0003173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014444 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008833 oboInOwl:hasDbXref "UMLS:C1834975" ; oboInOwl:id "HP:0008833" ; a owl:Class ; rdfs:label "Irregular acetabular roof" ; rdfs:subClassOf obo:HP_0003170 . obo:HP_0008835 obo:IAO_0000115 "There is normally one ossification center in the head of the femur. This term applies if there are multiple such centers." ; oboInOwl:hasDbXref "UMLS:C1846447" ; oboInOwl:id "HP:0008835" ; a owl:Class ; rdfs:comment "Additionally, the ossification center of the capital femoral epiphysis appears at the end of the first year after birth. This is not what this term refers to." ; rdfs:label "Multicentric femoral head ossification" ; rdfs:subClassOf obo:HP_0009107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006767 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008838 oboInOwl:hasDbXref "UMLS:C1857243" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of innermost long bone of upper arm" ; oboInOwl:id "HP:0008838" ; a owl:Class ; rdfs:label "Stippled calcification proximal humeral epiphyses" ; rdfs:subClassOf obo:HP_0003901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0008839 obo:IAO_0000115 "Underdevelopment of the bony pelvis." ; oboInOwl:hasAlternativeId "HP:0003373", "HP:0008816" ; oboInOwl:hasDbXref "UMLS:C3536734" ; oboInOwl:hasExactSynonym "Hypoplastic pelvic bones", "Small pelvis" ; oboInOwl:id "HP:0008839" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic pelvis" ; rdfs:subClassOf obo:HP_0009103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002355 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008843 oboInOwl:hasAlternativeId "HP:0008809" ; oboInOwl:hasDbXref "MSH:D015207", "SNOMEDCT_US:239872002", "UMLS:C0029410" ; oboInOwl:hasExactSynonym "Osteoarthritis of hip" ; oboInOwl:id "HP:0008843" ; a owl:Class ; rdfs:label "Hip osteoarthritis" ; rdfs:subClassOf obo:HP_0002758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008845 obo:IAO_0000115 "A type of disproportionate short stature characterized by disproportionate shortening of the medial parts of the extremities (forearm or lower leg)." ; oboInOwl:hasAlternativeId "HP:0008896", "HP:0008903", "HP:0008910" ; oboInOwl:hasDbXref "UMLS:C1855274" ; oboInOwl:hasExactSynonym "Dwarfism, short limb mesomelic", "Mesomelic dwarfism", "Short stature, disproportionate mesomelic", "Short stature, mesomelic" ; oboInOwl:id "HP:0008845" ; a owl:Class ; rdfs:label "Mesomelic short stature" ; rdfs:subClassOf obo:HP_0008873 . obo:HP_0008846 obo:IAO_0000115 "Intrauterine growth retardation that is 4 or more standard deviations below average, corrected for sex and gestational age." ; oboInOwl:hasAlternativeId "HP:0008899", "HP:0008906" ; oboInOwl:hasDbXref "UMLS:C1855843" ; oboInOwl:hasExactSynonym "Intrauterine growth retardation, severe", "Severe prenatal growth deficiency" ; oboInOwl:id "HP:0008846" ; a owl:Class ; rdfs:label "Severe intrauterine growth retardation" ; rdfs:subClassOf obo:HP_0001511 . obo:HP_0008848 obo:IAO_0000115 "A moderate degree of short stature, more than -3 SD but not more than -4 SD from mean corrected for age and sex." ; oboInOwl:hasAlternativeId "HP:0008891" ; oboInOwl:hasDbXref "UMLS:C1861519" ; oboInOwl:hasExactSynonym "Moderate short stature" ; oboInOwl:hasRelatedSynonym "Short stature, moderate" ; oboInOwl:id "HP:0008848" ; a owl:Class ; rdfs:label "Moderately short stature" ; rdfs:subClassOf obo:HP_0003508 . obo:HP_0008850 obo:IAO_0000115 "Severely slow or limited growth after birth, being four standard deviations or more below age- and sex-related norms." ; oboInOwl:hasAlternativeId "HP:0001521", "HP:0008854", "HP:0008911", "HP:0008932" ; oboInOwl:hasDbXref "UMLS:C1857641" ; oboInOwl:hasExactSynonym "Marked growth retardation", "Severe growth delay in children", "Severe postnatal growth deficiency", "Severe postnatal growth failure" ; oboInOwl:id "HP:0008850" ; a owl:Class ; rdfs:label "Severe postnatal growth retardation" ; rdfs:subClassOf obo:HP_0008897 . obo:HP_0008855 obo:IAO_0000115 "A moderate degree of slow or limited growth after birth, being between three and four standard deviations below age- and sex-related norms." ; oboInOwl:hasDbXref "UMLS:C4024616" ; oboInOwl:hasExactSynonym "Moderate growth delay in children" ; oboInOwl:id "HP:0008855" ; a owl:Class ; rdfs:label "Moderate postnatal growth retardation" ; rdfs:subClassOf obo:HP_0008897 . obo:HP_0008857 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with congenital onset recognizable at birth." ; oboInOwl:hasDbXref "UMLS:C3149908" ; oboInOwl:hasExactSynonym "Short-trunk dwarfism identifiable at birth" ; oboInOwl:id "HP:0008857" ; a owl:Class ; rdfs:label "Neonatal short-trunk short stature" ; rdfs:subClassOf obo:HP_0003521 . obo:HP_0008866 obo:IAO_0000115 "Insufficient weight gain or inappropriate weight loss for a child, that is attributed to an endogenous recurrent infections." ; oboInOwl:hasDbXref "UMLS:C1832323" ; oboInOwl:hasExactSynonym "Faltering weight secondary to recurrent infections", "Weight faltering secondary to recurrent infections" ; oboInOwl:id "HP:0008866" ; a owl:Class ; rdfs:label "Failure to thrive secondary to recurrent infections" ; rdfs:subClassOf obo:HP_0001508, obo:HP_0002719, obo:HP_0032169 . obo:HP_0008872 obo:IAO_0000115 "Impaired feeding performance of an infant as manifested by difficulties such as weak and ineffective sucking, brief bursts of sucking, and falling asleep during sucking. There may be difficulties with chewing or maintaining attention." ; oboInOwl:hasAlternativeId "HP:0002016", "HP:0002022", "HP:0002568" ; oboInOwl:hasDbXref "UMLS:C2674608" ; oboInOwl:id "HP:0008872" ; a owl:Class ; rdfs:label "Feeding difficulties in infancy" ; rdfs:subClassOf obo:HP_0011968 . obo:HP_0008873 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short limbs but an average-sized trunk." ; oboInOwl:hasAlternativeId "HP:0001523", "HP:0003505", "HP:0003509", "HP:0008858", "HP:0008869", "HP:0008875", "HP:0008880", "HP:0008881", "HP:0008889", "HP:0008912", "HP:0008914", "HP:0008928" ; oboInOwl:hasDbXref "UMLS:C1849937" ; oboInOwl:hasExactSynonym "Brachymelic dwarfism", "Disproportionate short limb dwarfism", "Dwarfism, short-limbed", "Micromelic dwarfism", "Short limb dwarfism, disproportionate", "Short stature, disproportionate short limb", "Short stature, disproportionate short-limb", "Short-limb dwarfism", "Short-limbed dwarfism" ; oboInOwl:hasRelatedSynonym "Short limb dwarfism" ; oboInOwl:id "HP:0008873" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A type of dwarfism (marked short stature with adult height below 147 cm) in which the limbs are disproportionatley affected. Note that brachymelia is a general term refering to shortening of the limbs. Micromelia refers to the shortening of entire limbs (in contrast to rhizomelia, mesomelia, and acromelia, which refer to shortening of the proximal, middle, or distal portions of the limbs)." ; rdfs:label "Disproportionate short-limb short stature" ; rdfs:subClassOf obo:HP_0003498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008883 obo:IAO_0000115 "Intrauterine growth retardation that is at least 2 standard deviations (SD) below average, but not as low as 3 SD, corrected for sex and gestational age." ; oboInOwl:hasAlternativeId "HP:0008861" ; oboInOwl:hasDbXref "UMLS:C1840006" ; oboInOwl:hasExactSynonym "Mild prenatal growth deficiency" ; oboInOwl:id "HP:0008883" ; a owl:Class ; rdfs:label "Mild intrauterine growth retardation" ; rdfs:subClassOf obo:HP_0001511 . obo:HP_0008887 obo:IAO_0000115 "A loss of adipose tissue." ; oboInOwl:hasAlternativeId "HP:0008938" ; oboInOwl:hasDbXref "UMLS:C4024615" ; oboInOwl:hasExactSynonym "Loss of fat tissue" ; oboInOwl:id "HP:0008887" ; a owl:Class ; rdfs:label "Adipose tissue loss" ; rdfs:subClassOf obo:HP_0040063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008890 oboInOwl:hasDbXref "UMLS:C1860105" ; oboInOwl:id "HP:0008890" ; a owl:Class ; rdfs:label "Severe short-limb dwarfism" ; rdfs:subClassOf obo:HP_0008873 . obo:HP_0008897 obo:IAO_0000115 "Slow or limited growth after birth." ; oboInOwl:hasAlternativeId "HP:0008844", "HP:0008865", "HP:0008868", "HP:0008901", "HP:0008918" ; oboInOwl:hasDbXref "UMLS:C1859778" ; oboInOwl:hasExactSynonym "Growth delay as children", "Growth retardation as children", "Postnatal growth deceleration", "Postnatal growth deficiency", "Postnatal growth failure" ; oboInOwl:id "HP:0008897" ; a owl:Class ; rdfs:label "Postnatal growth retardation" ; rdfs:subClassOf obo:HP_0001510 . obo:HP_0008905 obo:IAO_0000115 "Disproportionate shortening of the proximal segment of limbs (i.e. the femur and humerus)." ; oboInOwl:hasAlternativeId "HP:0002968", "HP:0003520", "HP:0008852", "HP:0008877" ; oboInOwl:hasDbXref "UMLS:C1866730" ; oboInOwl:hasExactSynonym "Disproportionately short upper portion of limb", "Rhizomelic dwarfism", "Rhizomelic limb shortening", "Rhizomelic short limbs", "Rhizomelic short stature", "Rhizomelic shortening", "Short stature, rhizomelic", "Symmetrical rhizomelic limb shortening" ; oboInOwl:id "HP:0008905" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Rhizomelia" ; rdfs:subClassOf obo:HP_0008873, obo:HP_0009826 . obo:HP_0008909 oboInOwl:hasAlternativeId "HP:0003506" ; oboInOwl:hasDbXref "UMLS:C2674171" ; oboInOwl:hasExactSynonym "Lethal micromelic dwarfism", "Lethal short-limbed dwarfism" ; oboInOwl:id "HP:0008909" ; a owl:Class ; rdfs:label "Lethal short-limbed short stature" ; rdfs:subClassOf obo:HP_0008873 . obo:HP_0008915 obo:IAO_0000115 "Truncal obesity with onset during childhood, defined as between 2 and 10 years of age." ; oboInOwl:hasAlternativeId "HP:0008874" ; oboInOwl:hasDbXref "UMLS:C1859846" ; oboInOwl:hasExactSynonym "Truncal obesity apparent in childhood" ; oboInOwl:id "HP:0008915" ; a owl:Class ; rdfs:label "Childhood-onset truncal obesity" ; rdfs:subClassOf obo:HP_0001956 . obo:HP_0008921 obo:IAO_0000115 "A type of short-limbed dwarfism that is manifest beginning in the neonatal period." ; oboInOwl:hasAlternativeId "HP:0001536", "HP:0008894", "HP:0008902", "HP:0008924" ; oboInOwl:hasDbXref "UMLS:C1850171" ; oboInOwl:hasExactSynonym "Dwarfism, neonatal short-limbed", "Neonatal short-limbed dwarfism", "Short limb dwarfism recognisable at birth", "Short limb dwarfism recognizable at birth", "Short-limb dwarfism identifiable at birth", "Short-limb dwarfism identifiable neonatally", "Short-limbed dwarfism identifiable at birth" ; oboInOwl:id "HP:0008921" ; a owl:Class ; rdfs:label "Neonatal short-limb short stature" ; rdfs:subClassOf obo:HP_0008873 . obo:HP_0008922 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in childhood." ; oboInOwl:hasAlternativeId "HP:0003522" ; oboInOwl:hasDbXref "UMLS:C3148833" ; oboInOwl:hasExactSynonym "Childhood-onset short-trunk short stature", "Disproportionate short-trunk short stature, identifiable in childhood", "Short-trunk dwarfism identifiable during childhood" ; oboInOwl:id "HP:0008922" ; a owl:Class ; rdfs:label "Childhood-onset short-trunk short stature" ; rdfs:subClassOf obo:HP_0003521 . obo:HP_0008929 oboInOwl:hasDbXref "UMLS:C4024614" ; oboInOwl:id "HP:0008929" ; a owl:Class ; rdfs:label "Asymmetric short stature" ; rdfs:subClassOf obo:HP_0004322 . obo:HP_0008935 obo:IAO_0000115 "Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period and affecting the entire musculature." ; oboInOwl:hasDbXref "UMLS:C1845123" ; oboInOwl:hasExactSynonym "Generalised low muscle tone in neonate", "Generalised neonatal hypotonia", "Generalized low muscle tone in neonate", "Hypotonia, neonatal, generalised", "Hypotonia, neonatal, generalized" ; oboInOwl:id "HP:0008935" ; a owl:Class ; rdfs:label "Generalized neonatal hypotonia" ; rdfs:subClassOf obo:HP_0001319 . obo:HP_0008936 obo:IAO_0000115 "Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk." ; oboInOwl:hasAlternativeId "HP:0002320" ; oboInOwl:hasDbXref "UMLS:C1853743" ; oboInOwl:hasExactSynonym "Low muscle tone in trunk", "Muscular hypotonia of the trunk", "Truncal hypotonia" ; oboInOwl:id "HP:0008936" ; a owl:Class ; rdfs:label "Axial hypotonia" ; rdfs:subClassOf obo:HP_0001252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001619 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004479 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008940 obo:IAO_0000115 "A generalized form of lymphadenopathy." ; oboInOwl:hasDbXref "SNOMEDCT_US:274741002", "UMLS:C0476486" ; oboInOwl:hasExactSynonym "Generalised lymphadenopathy", "Generalised swelling of lymph nodes", "Generalized swelling of lymph nodes", "Swollen lymph nodes affecting all regions of the body" ; oboInOwl:id "HP:0008940" ; a owl:Class ; rdfs:label "Generalized lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0008942 obo:IAO_0000115 "An acute form of rhabdomyolysis." ; oboInOwl:hasDbXref "UMLS:C3807306" ; oboInOwl:hasExactSynonym "Rhabdomyolysis, acute" ; oboInOwl:id "HP:0008942" ; a owl:Class ; rdfs:label "Acute rhabdomyolysis" ; rdfs:subClassOf obo:HP_0003201 . obo:HP_0008944 obo:IAO_0000115 "Muscular atrophy of distal leg muscles." ; oboInOwl:hasAlternativeId "HP:0003442", "HP:0003714", "HP:0006975", "HP:0008949", "HP:0009001" ; oboInOwl:hasDbXref "UMLS:C1836451", "UMLS:C1866863", "UMLS:C3806644" ; oboInOwl:hasExactSynonym "Lower leg amyotrophy", "Lower limb degeneration", "Muscle atrophy, lower limb, distal" ; oboInOwl:hasRelatedSynonym "Lower limb atrophy", "Lower limb muscle hypotrophy" ; oboInOwl:id "HP:0008944" ; a owl:Class ; rdfs:comment "Distal lower limb muscle atrophy is commonly due to peripheral neuropathy." ; rdfs:label "Distal lower limb amyotrophy" ; rdfs:subClassOf obo:HP_0003693, obo:HP_0007210 . obo:HP_0008945 oboInOwl:hasDbXref "UMLS:C1835993" ; oboInOwl:id "HP:0008945" ; a owl:Class ; rdfs:label "Loss of ability to walk in early childhood" ; rdfs:subClassOf obo:HP_0002505 . obo:HP_0008946 obo:IAO_0000115 "Atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle." ; oboInOwl:hasDbXref "UMLS:C4021528" ; oboInOwl:hasExactSynonym "Hip girdle amyotrophy" ; oboInOwl:id "HP:0008946" ; a owl:Class ; rdfs:label "Pelvic girdle amyotrophy" ; rdfs:subClassOf obo:HP_0003797 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0003749 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0008988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008947 obo:IAO_0000115 "Muscular hypotonia (abnormally low muscle tone) manifesting in infancy." ; oboInOwl:hasAlternativeId "HP:0002449", "HP:0002523", "HP:0010572" ; oboInOwl:hasDbXref "UMLS:C1860834" ; oboInOwl:hasExactSynonym "Decreased muscle tone in infant", "Hypotonia early", "Hypotonia in infancy", "Hypotonia, early", "Infantile hypotonia" ; oboInOwl:id "HP:0008947" ; a owl:Class ; rdfs:comment "This term should not be used for new annotations. Instead, state the type of onset of hypotonia more exactly." ; rdfs:label "Infantile muscular hypotonia" ; rdfs:subClassOf obo:HP_0001252 . obo:HP_0008948 obo:IAO_0000115 "Muscular atrophy affecting proximally located muscles of the arms." ; oboInOwl:hasAlternativeId "HP:0008995" ; oboInOwl:hasDbXref "UMLS:C1866013" ; oboInOwl:hasExactSynonym "Proximal muscle atrophy in upper limbs", "Proximal upper limb muscle atrophy" ; oboInOwl:id "HP:0008948" ; a owl:Class ; rdfs:label "Proximal upper limb amyotrophy" ; rdfs:subClassOf obo:HP_0001457, obo:HP_0007126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004255 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008952 obo:IAO_0000115 "Underdevelopment of muscles of the shoulder." ; oboInOwl:hasDbXref "UMLS:C1969001" ; oboInOwl:hasExactSynonym "Underdeveloped shoulder muscle" ; oboInOwl:id "HP:0008952" ; a owl:Class ; rdfs:label "Shoulder muscle hypoplasia" ; rdfs:subClassOf obo:HP_0001464, obo:HP_0009004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008953 obo:IAO_0000115 "Underdevelopment of the pectoralis major." ; oboInOwl:hasDbXref "UMLS:C1840086" ; oboInOwl:hasExactSynonym "Pectoralis major muscle hypoplasia" ; oboInOwl:id "HP:0008953" ; a owl:Class ; rdfs:comment "The pectoralis major is a thick, fan-shaped muscle of the anterior chest." ; rdfs:label "Pectoralis major hypoplasia" ; rdfs:subClassOf obo:HP_0011957 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008954 obo:IAO_0000115 "Atrophy of the intrinsic muscle groups of the hand, comprising the thenar and hypothenar muscles; the interossei muscles; and the lumbrical muscles." ; oboInOwl:hasDbXref "UMLS:C1864716" ; oboInOwl:id "HP:0008954" ; a owl:Class ; rdfs:label "Intrinsic hand muscle atrophy" ; rdfs:subClassOf obo:HP_0009130 . obo:HP_0008955 obo:IAO_0000115 "Progressive muscular atrophy affecting muscles in the distal portions of the extremities." ; oboInOwl:hasDbXref "UMLS:C4024613" ; oboInOwl:id "HP:0008955" ; a owl:Class ; rdfs:label "Progressive distal muscular atrophy" ; rdfs:subClassOf obo:HP_0003693 . obo:HP_0008956 obo:IAO_0000115 "Muscular atrophy affecting proximally located muscles of the legs, i.e., of the thigh." ; oboInOwl:hasAlternativeId "HP:0003748", "HP:0008974" ; oboInOwl:hasDbXref "UMLS:C1836767" ; oboInOwl:hasExactSynonym "Amyotrophy involving the thigh", "Amyotrophy of the thigh musculature", "Proximal lower limb muscle atrophy", "Thigh muscle atrophy", "Wasting of thigh muscle" ; oboInOwl:id "HP:0008956" ; a owl:Class ; rdfs:label "Proximal lower limb amyotrophy" ; rdfs:subClassOf obo:HP_0001441, obo:HP_0007126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004252 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008959 obo:IAO_0000115 "Reduced strength of the distal musculature of the arms." ; oboInOwl:hasDbXref "UMLS:C3150620" ; oboInOwl:id "HP:0008959" ; a owl:Class ; rdfs:label "Distal upper limb muscle weakness" ; rdfs:subClassOf obo:HP_0002460, obo:HP_0002817 . obo:HP_0008962 obo:IAO_0000115 "Underdevelopment of the muscuklature of the calf." ; oboInOwl:hasDbXref "UMLS:C3805450" ; oboInOwl:hasExactSynonym "Hypoplastic calf muscles", "Underdeveloped calf muscles" ; oboInOwl:id "HP:0008962" ; a owl:Class ; rdfs:label "Calf muscle hypoplasia" ; rdfs:subClassOf obo:HP_0001430, obo:HP_0009004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009004 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008963 obo:IAO_0000115 "Muscle weakness affecting the tibialis anterior muscle." ; oboInOwl:hasDbXref "UMLS:C4024612" ; oboInOwl:id "HP:0008963" ; a owl:Class ; rdfs:comment "This is a bundled term which should be made obsolete." ; rdfs:label "Tibialis muscle weakness" ; rdfs:subClassOf obo:HP_0009053 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002460 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001385 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008964 obo:IAO_0000115 "Muscular atrophy that does not display a progression in severity with time." ; oboInOwl:hasDbXref "UMLS:C4024611" ; oboInOwl:id "HP:0008964" ; a owl:Class ; rdfs:label "Nonprogressive muscular atrophy" ; rdfs:subClassOf obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003202 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002026 ] ) ] ] . obo:HP_0008967 obo:IAO_0000115 "A type of muscle stiffness that occurs following physical exertion." ; oboInOwl:hasAlternativeId "HP:0003633" ; oboInOwl:hasDbXref "UMLS:C1855579" ; oboInOwl:hasExactSynonym "Exercise-induced muscle stiffness", "Muscle stiffness with exercise", "Muscle stiffness, exercise-induced" ; oboInOwl:id "HP:0008967" ; a owl:Class ; rdfs:label "Exercise-induced muscle stiffness" ; rdfs:subClassOf obo:HP_0003552 . obo:HP_0008968 obo:IAO_0000115 "Muscle hypertrophy primarily affecting the legs." ; oboInOwl:hasDbXref "UMLS:C1850663" ; oboInOwl:id "HP:0008968" ; a owl:Class ; rdfs:label "Muscle hypertrophy of the lower extremities" ; rdfs:subClassOf obo:HP_0001437, obo:HP_0003712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008969 oboInOwl:hasDbXref "UMLS:C4024610" ; oboInOwl:id "HP:0008969" ; a owl:Class ; rdfs:label "Leg muscle stiffness" ; rdfs:subClassOf obo:HP_0001437, obo:HP_0003552 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006067 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008970 oboInOwl:hasDbXref "MSH:C562932", "SNOMEDCT_US:240074006", "UMLS:C0410192" ; oboInOwl:id "HP:0008970" ; a owl:Class ; rdfs:label "Scapulohumeral muscular dystrophy" ; rdfs:subClassOf obo:HP_0003560 . obo:HP_0008972 obo:IAO_0000115 "Decreased activity of the mitochondrial respiratory chain." ; oboInOwl:hasDbXref "UMLS:C1835995", "UMLS:C3276441", "UMLS:C4024609" ; oboInOwl:hasRelatedSynonym "Decreased activities of mitochondrial-encoded respiratory chain complexes", "Decreased activity of mitochondrial respiratory complexes" ; oboInOwl:id "HP:0008972" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial respiratory chain" ; rdfs:subClassOf obo:HP_0011922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008978 oboInOwl:hasDbXref "UMLS:C4024608" ; oboInOwl:id "HP:0008978" ; a owl:Class ; rdfs:label "Necrotizing myopathy" ; rdfs:subClassOf obo:HP_0003198 . obo:HP_0008981 obo:IAO_0000115 "Muscle hypertrophy affecting the calf muscles." ; oboInOwl:hasAlternativeId "HP:0003703", "HP:0009024" ; oboInOwl:hasDbXref "UMLS:C1843057" ; oboInOwl:hasExactSynonym "Calf hypertrophy", "Increased size of calf muscles", "Muscular hypertrophy of the calf muscles" ; oboInOwl:id "HP:0008981" ; a owl:Class ; rdfs:comment "Distal lower limb hypertrophy" ; rdfs:label "Calf muscle hypertrophy" ; rdfs:subClassOf obo:HP_0001430, obo:HP_0008968 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0003712 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008984 obo:IAO_0000115 "Underdevelopment of muscles of the neck." ; oboInOwl:hasDbXref "UMLS:C1969000", "UMLS:C4280408", "UMLS:C4280409" ; oboInOwl:hasExactSynonym "Decreased size of neck muscle", "Small neck muscle", "Underdevelopment of neck muscle" ; oboInOwl:hasRelatedSynonym "Deficiency of neck muscle", "Hypotrophic neck muscle" ; oboInOwl:id "HP:0008984" ; a owl:Class ; rdfs:label "Neck muscle hypoplasia" ; rdfs:subClassOf obo:HP_0009004, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008985 obo:IAO_0000115 "An abnormal increase in the amount of intramuscular fat tissue." ; oboInOwl:hasDbXref "UMLS:C1835389" ; oboInOwl:hasExactSynonym "Increased IM fat", "Increased intramuscular fat" ; oboInOwl:id "HP:0008985" ; a owl:Class ; rdfs:label "Increased intramuscular fat" ; rdfs:subClassOf obo:HP_0009126, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008986 obo:IAO_0000115 "Congenital lack, i.e., aplasia of the diaphragm." ; oboInOwl:hasDbXref "SNOMEDCT_US:702613006", "SNOMEDCT_US:72424001", "UMLS:C0221360" ; oboInOwl:hasExactSynonym "Absent diaphragm" ; oboInOwl:hasRelatedSynonym "Agenesis of diaphragm" ; oboInOwl:id "HP:0008986" ; a owl:Class ; rdfs:comment "An extremely large diaphragmatic defect, or apparent absence of the hemidiaphragm, is called agenesis of the diaphragm; this defect probably represents the severe end of the Bochdalek hernia spectrum rather than a distinct entity." ; rdfs:label "Agenesis of the diaphragm" ; rdfs:subClassOf obo:HP_0010315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008988 obo:IAO_0000115 "Muscular atrophy affecting the muscles that attach to the pelvic girdle (the gluteal muscles, the lateral rotators, adductor magnus, adductor brevis, adductor longus, pectineus, and gracilis muscles)." ; oboInOwl:hasAlternativeId "HP:0008992" ; oboInOwl:hasDbXref "UMLS:C0240679" ; oboInOwl:hasExactSynonym "Pelvic girdle muscle wasting" ; oboInOwl:id "HP:0008988" ; a owl:Class ; rdfs:label "Pelvic girdle muscle atrophy" ; rdfs:subClassOf obo:HP_0001445, obo:HP_0001471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001497 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008991 obo:IAO_0000115 "Sudden and involuntary contractions of one or more muscles of the leg brought on by physical exertion." ; oboInOwl:hasDbXref "UMLS:C4024607" ; oboInOwl:id "HP:0008991" ; a owl:Class ; rdfs:label "Exercise-induced leg cramps" ; rdfs:subClassOf obo:HP_0003710 . obo:HP_0008993 obo:IAO_0000115 "An abnormal increase in the amount of intraabdominal fat tissue." ; oboInOwl:hasDbXref "UMLS:C1835390" ; oboInOwl:id "HP:0008993" ; a owl:Class ; rdfs:label "Increased intraabdominal fat" ; rdfs:subClassOf obo:HP_0009126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008994 obo:IAO_0000115 "A lack of strength of the proximal muscles of the legs." ; oboInOwl:hasAlternativeId "HP:0002455", "HP:0008941" ; oboInOwl:hasDbXref "UMLS:C1866010" ; oboInOwl:hasExactSynonym "Muscle weakness, proximal, lower limbs" ; oboInOwl:id "HP:0008994" ; a owl:Class ; rdfs:label "Proximal muscle weakness in lower limbs" ; rdfs:subClassOf obo:HP_0003690, obo:HP_0003701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004482 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0008997 obo:IAO_0000115 "A lack of strength of the proximal muscles of the arms." ; oboInOwl:hasDbXref "UMLS:C1866012" ; oboInOwl:id "HP:0008997" ; a owl:Class ; rdfs:label "Proximal muscle weakness in upper limbs" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0003484, obo:HP_0003701 . obo:HP_0008998 obo:IAO_0000115 "Underdevelopment of the pectoral muscle." ; oboInOwl:hasDbXref "UMLS:C1846477" ; oboInOwl:hasExactSynonym "Hypoplastic pectoral muscle", "Small pec muscle", "Underdeveloped pec muscle" ; oboInOwl:id "HP:0008998" ; a owl:Class ; rdfs:label "Pectoralis hypoplasia" ; rdfs:subClassOf obo:HP_0005258, obo:HP_0009004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009002 obo:IAO_0000115 "Loss (reduction of previously present) of subcutaneous adipose tissue in the region of the trunk." ; oboInOwl:hasAlternativeId "HP:0008989" ; oboInOwl:hasDbXref "UMLS:C1835384" ; oboInOwl:hasExactSynonym "Loss of fat tissue in trunk", "Loss of subcutaneous truncal adipose tissue", "Loss of truncal adipose tissue" ; oboInOwl:id "HP:0009002" ; a owl:Class ; rdfs:label "Loss of truncal subcutaneous adipose tissue" ; rdfs:subClassOf obo:HP_0008887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009003 obo:IAO_0000115 "The presence of an abnormally increased amount of subcutaneous adipose tissue in the trunk of the body." ; oboInOwl:hasDbXref "UMLS:C1837781" ; oboInOwl:hasExactSynonym "Increased fat below the skin in trunk" ; oboInOwl:id "HP:0009003" ; a owl:Class ; rdfs:label "Increased subcutaneous truncal adipose tissue" ; rdfs:subClassOf obo:HP_0001001, obo:HP_0009126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009004 obo:IAO_0000115 "Underdevelopment of the musculature." ; oboInOwl:hasAlternativeId "HP:0009034" ; oboInOwl:hasDbXref "SNOMEDCT_US:205530002", "UMLS:C0240414" ; oboInOwl:hasExactSynonym "Muscle hypoplasia", "Poorly developed skeletal musculature", "Underdeveloped muscle", "Underdeveloped muscles" ; oboInOwl:id "HP:0009004" ; a owl:Class ; rdfs:label "Hypoplasia of the musculature" ; rdfs:subClassOf obo:HP_0001460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009005 oboInOwl:hasDbXref "UMLS:C1834536" ; oboInOwl:hasRelatedSynonym "Intrinsic hand muscle weakness" ; oboInOwl:id "HP:0009005" ; a owl:Class ; rdfs:label "Weakness of the intrinsic hand muscles" ; rdfs:subClassOf obo:HP_0001421 . obo:HP_0009007 obo:IAO_0000115 "Underdevelopment of the biceps muscle." ; oboInOwl:hasDbXref "UMLS:C1862499" ; oboInOwl:hasExactSynonym "Hypoplastic biceps", "Underdeveloped biceps" ; oboInOwl:id "HP:0009007" ; a owl:Class ; rdfs:label "Biceps hypoplasia" ; rdfs:subClassOf obo:HP_0009782, obo:HP_0030239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001507 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009011 obo:IAO_0000115 "Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula." ; oboInOwl:hasDbXref "UMLS:C1868167" ; oboInOwl:id "HP:0009011" ; a owl:Class ; rdfs:label "Hypoplasia of serratus anterior muscle" ; rdfs:subClassOf obo:HP_0009131 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001125 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009013 oboInOwl:hasDbXref "MSH:C535561", "UMLS:C2930932" ; oboInOwl:id "HP:0009013" ; a owl:Class ; rdfs:label "Congenital absence of gluteal muscles" ; rdfs:subClassOf obo:HP_0001443, obo:HP_0001471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009016 obo:IAO_0000115 "Underdevelopment of muscles of the arm." ; oboInOwl:hasDbXref "UMLS:C1846478" ; oboInOwl:hasExactSynonym "Underdevelopment of upper limb muscles" ; oboInOwl:id "HP:0009016" ; a owl:Class ; rdfs:label "Upper limb muscle hypoplasia" ; rdfs:subClassOf obo:HP_0001467, obo:HP_0009004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009017 obo:IAO_0000115 "Loss (reduction of previously present) of subcutaneous adipose tissue in the gluteal region." ; oboInOwl:hasDbXref "UMLS:C4024606" ; oboInOwl:hasExactSynonym "Loss of fat tissue below the skin in gluts" ; oboInOwl:id "HP:0009017" ; a owl:Class ; rdfs:label "Loss of gluteal subcutaneous adipose tissue" ; rdfs:subClassOf obo:HP_0008887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013691 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009019 oboInOwl:hasDbXref "UMLS:C1837510" ; oboInOwl:hasExactSynonym "Atrophy of facial adipose tissue", "Facial fat atrophy", "Facial fat wasting", "Loss of subcutaneous adipose tissue from face, progressive", "Progressive loss of facial fat", "Progressive loss of facial subcutaneous adipose tissue", "Progressive loss of subcutaneous adipose tissue from face" ; oboInOwl:id "HP:0009019" ; a owl:Class ; rdfs:label "Progressive loss of facial adipose tissue" ; rdfs:subClassOf obo:HP_0000292 . obo:HP_0009020 obo:IAO_0000115 "An abnormally increased tendency towards muscle fatigue induced by physical exercise." ; oboInOwl:hasDbXref "UMLS:C1855580" ; oboInOwl:id "HP:0009020" ; a owl:Class ; rdfs:label "Exercise-induced muscle fatigue" ; rdfs:subClassOf obo:HP_0003750 . obo:HP_0009023 obo:IAO_0000115 "Decreased strength of the abdominal musculature." ; oboInOwl:hasAlternativeId "HP:0001546", "HP:0004873" ; oboInOwl:hasDbXref "UMLS:C4021527" ; oboInOwl:hasExactSynonym "Lax abdominal musculature" ; oboInOwl:id "HP:0009023" ; a owl:Class ; rdfs:comment "This may be associated with protuberance of the abdomen." ; rdfs:label "Abdominal wall muscle weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009025 obo:IAO_0000115 "The presence of an abnormally increased amount of connective tissue." ; oboInOwl:hasDbXref "UMLS:C1866021" ; oboInOwl:id "HP:0009025" ; a owl:Class ; rdfs:label "Increased connective tissue" ; rdfs:subClassOf obo:HP_0003549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009026 obo:IAO_0000115 "Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula." ; oboInOwl:hasDbXref "UMLS:C3805860" ; oboInOwl:id "HP:0009026" ; a owl:Class ; rdfs:label "Hypoplasia of latissimus dorsi muscle" ; rdfs:subClassOf obo:HP_0009131 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001112 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009027 obo:IAO_0000115 "Weakness of the muscles responsible for dorsiflexion of the foot, that is, of the movement of the toes towards the shin. The foot dorsiflexors include the tibialis anterior, the extensor hallucis longus, the extensor digitorum longus, and the peroneus tertius muscles." ; oboInOwl:hasAlternativeId "HP:0003377" ; oboInOwl:hasDbXref "SNOMEDCT_US:6077001", "UMLS:C0085684", "UMLS:C1866141" ; oboInOwl:hasExactSynonym "Foot drop", "Foot extensor weakness", "Footdrop", "Inability to heel walk", "Inability to walk on heels" ; oboInOwl:id "HP:0009027" ; a owl:Class ; rdfs:comment "Dorsiflexion of the foot extends the foot superiorly, as if taking the foot off the gas pedal." ; rdfs:label "Foot dorsiflexor weakness" ; rdfs:subClassOf obo:HP_0003690 . obo:HP_0009028 obo:IAO_0000115 "Generalized weakness of the muscles of the arms and legs." ; oboInOwl:hasDbXref "UMLS:C4024605" ; oboInOwl:hasExactSynonym "Generalised weakness of limb muscles" ; oboInOwl:id "HP:0009028" ; a owl:Class ; rdfs:label "Generalized weakness of limb muscles" ; rdfs:subClassOf obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0009031 obo:IAO_0000115 "Atrophy of the muscles of the ankle." ; oboInOwl:hasDbXref "UMLS:C4024604" ; oboInOwl:id "HP:0009031" ; a owl:Class ; rdfs:label "Amyotrophy of ankle musculature" ; rdfs:subClassOf obo:HP_0001436 . obo:HP_0009037 oboInOwl:hasDbXref "MSH:C566670", "UMLS:C1866774" ; oboInOwl:id "HP:0009037" ; a owl:Class ; rdfs:label "Segmental spinal muscular atrophy" ; rdfs:subClassOf obo:HP_0007269 . obo:HP_0009042 obo:IAO_0100001 "HP:0003712" ; oboInOwl:id "HP:0009042" ; a owl:Class ; rdfs:label "obsolete Marked muscular hypertrophy" ; owl:deprecated true . obo:HP_0009044 obo:IAO_0100001 "HP:0030241" ; oboInOwl:id "HP:0009044" ; a owl:Class ; rdfs:label "obsolete Hypoplasia of deltoid muscle" ; owl:deprecated true . obo:HP_0009045 obo:IAO_0000115 "Rhabdomyolysis induced by exercise." ; oboInOwl:hasDbXref "UMLS:C4021526" ; oboInOwl:hasExactSynonym "Rhabdomyolysis with exercise" ; oboInOwl:id "HP:0009045" ; a owl:Class ; rdfs:label "Exercise-induced rhabdomyolysis" ; rdfs:subClassOf obo:HP_0003201 . obo:HP_0009046 obo:IAO_0000115 "Reduced ability to run." ; oboInOwl:hasDbXref "SNOMEDCT_US:282479002", "UMLS:C0560346" ; oboInOwl:hasExactSynonym "Difficulty running" ; oboInOwl:id "HP:0009046" ; a owl:Class ; rdfs:label "Difficulty running" ; rdfs:subClassOf obo:HP_0004302 . obo:HP_0009049 obo:IAO_0000115 "Atrophy of the peroneous muscles, peroneus longus (also known as Fibularis longus), Peroneus brevis (also known as fibularis brevis, and Peroneus tertius (also known as fibularis tertius)." ; oboInOwl:hasAlternativeId "HP:0008939", "HP:0008982" ; oboInOwl:hasDbXref "UMLS:C1389118" ; oboInOwl:hasExactSynonym "Peroneal atrophy" ; oboInOwl:id "HP:0009049" ; a owl:Class ; rdfs:comment "The peroneus muscles (longus, brevis, and tertius) originate on the fibula and insert on the metatarsals." ; rdfs:label "Peroneal muscle atrophy" ; rdfs:subClassOf obo:HP_0001430, obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009050 obo:IAO_0000115 "Muscular atrophy involving the quadriceps muscle." ; oboInOwl:hasDbXref "UMLS:C4024603" ; oboInOwl:hasExactSynonym "Wasting of quad muscles" ; oboInOwl:id "HP:0009050" ; a owl:Class ; rdfs:label "Quadriceps muscle atrophy" ; rdfs:subClassOf obo:HP_0008956 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009051 obo:IAO_0000115 "An increased amount of glycogen in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C1968729" ; oboInOwl:id "HP:0009051" ; a owl:Class ; rdfs:label "Increased muscle glycogen content" ; rdfs:subClassOf obo:HP_0012269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009053 obo:IAO_0000115 "Reduced strength of the distal musculature of the legs." ; oboInOwl:hasAlternativeId "HP:0003485", "HP:0009035" ; oboInOwl:hasDbXref "UMLS:C1836450" ; oboInOwl:hasExactSynonym "Distal muscle weakness in lower limbs", "Muscle weakness, lower limb, distal" ; oboInOwl:id "HP:0009053" ; a owl:Class ; rdfs:comment "This finding can be due to peripheral neuropathy." ; rdfs:label "Distal lower limb muscle weakness" ; rdfs:subClassOf obo:HP_0002460, obo:HP_0002814, obo:HP_0007340 . obo:HP_0009054 oboInOwl:hasDbXref "MSH:C536624", "UMLS:C2931268" ; oboInOwl:id "HP:0009054" ; a owl:Class ; rdfs:label "Scapuloperoneal myopathy" ; rdfs:subClassOf obo:HP_0001430, obo:HP_0001465 . obo:HP_0009055 obo:IAO_0000115 "Generalized (unlocalized) atrophy affecting muscles of the limbs in both proximal and distal locations." ; oboInOwl:hasAlternativeId "HP:0003788" ; oboInOwl:hasDbXref "UMLS:C1838114" ; oboInOwl:hasExactSynonym "Generalised limb muscle atrophy", "Generalised muscle atrophy, proximal and distal", "Generalised muscle wasting", "Generalized muscle atrophy, proximal and distal", "Generalized muscle wasting" ; oboInOwl:id "HP:0009055" ; a owl:Class ; rdfs:label "Generalized limb muscle atrophy" ; rdfs:subClassOf obo:HP_0003700 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0002403 ] ) ] ] . obo:HP_0009056 oboInOwl:hasDbXref "UMLS:C4024602" ; oboInOwl:hasExactSynonym "Loss of fat tissue below the skin from upper limbs" ; oboInOwl:id "HP:0009056" ; a owl:Class ; rdfs:label "Loss of subcutaneous adipose tissue from upper limbs" ; rdfs:subClassOf obo:HP_0003635 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009058 obo:IAO_0000115 "An abnormal accumulation of lipids in skeletal muscle." ; oboInOwl:hasAlternativeId "HP:0100949" ; oboInOwl:hasDbXref "UMLS:C1837262" ; oboInOwl:hasExactSynonym "Fat accumulation in muscle fibers", "Fat accumulation in muscle fibres", "Fat deposits in muscle fibers", "Fat deposits in muscle fibres", "Increased muscle lipid content", "Lipid accumulation in skeletal muscle", "Muscle lipidosis", "Skeletal muscle lipid accumulation" ; oboInOwl:id "HP:0009058" ; a owl:Class ; rdfs:comment "Increased neutral lipid content may be observed on muscle biopsies specimen with the specific staining of Sudan black or oil red O techniques by optic microscopy." ; rdfs:label "Increased muscle lipid content" ; rdfs:subClassOf obo:HP_0034370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18059 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009059 oboInOwl:hasDbXref "MSH:D052497", "SNOMEDCT_US:284449005", "SNOMEDCT_US:86907008", "UMLS:C0221032" ; oboInOwl:hasExactSynonym "Congenital generalised lipodystrophy" ; oboInOwl:id "HP:0009059" ; a owl:Class ; rdfs:label "Congenital generalized lipodystrophy" ; rdfs:subClassOf obo:HP_0009125 . obo:HP_0009060 obo:IAO_0000115 "Atrophy of the muscles that are responsible for moving the scapula, which are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." ; oboInOwl:hasDbXref "UMLS:C3805969" ; oboInOwl:id "HP:0009060" ; a owl:Class ; rdfs:comment "Need to add new UBERON term for scapula muscle" ; rdfs:label "Scapular muscle atrophy" ; rdfs:subClassOf obo:HP_0001465 . obo:HP_0009062 obo:IAO_0000115 "Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk and with onset in infancy." ; oboInOwl:hasDbXref "UMLS:C3806604" ; oboInOwl:hasExactSynonym "Hypotonia, axial, in infancy" ; oboInOwl:id "HP:0009062" ; a owl:Class ; rdfs:label "Infantile axial hypotonia" ; rdfs:subClassOf obo:HP_0008936, obo:HP_0008947 . obo:HP_0009063 obo:IAO_0000115 "Progressively reduced strength of the distal musculature." ; oboInOwl:hasAlternativeId "HP:0008933", "HP:0009022", "HP:0009057" ; oboInOwl:hasDbXref "UMLS:C1836609" ; oboInOwl:hasExactSynonym "Muscle weakness, distal, progressive", "Muscle weakness, progressive, distal" ; oboInOwl:id "HP:0009063" ; a owl:Class ; rdfs:label "Progressive distal muscle weakness" ; rdfs:subClassOf obo:HP_0002460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002460 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0009064 obo:IAO_0000115 "Generalized degenerative changes of the fat tissue." ; oboInOwl:hasAlternativeId "HP:0008966" ; oboInOwl:hasDbXref "MSH:D052497", "SNOMEDCT_US:284449005", "SNOMEDCT_US:86907008", "UMLS:C0221032" ; oboInOwl:hasExactSynonym "Generalised lipodystrophy", "Lipodystrophy, generalised", "Lipodystrophy, generalized" ; oboInOwl:id "HP:0009064" ; a owl:Class ; rdfs:label "Generalized lipodystrophy" ; rdfs:subClassOf obo:HP_0009125 . obo:HP_0009067 obo:IAO_0000115 "Progressive spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." ; oboInOwl:hasDbXref "UMLS:C4082951" ; oboInOwl:hasExactSynonym "Progressive spinal muscle degeneration", "Progressive spinal muscle wasting" ; oboInOwl:id "HP:0009067" ; a owl:Class ; rdfs:label "Progressive spinal muscular atrophy" ; rdfs:subClassOf obo:HP_0007269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0007269 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0009069 oboInOwl:hasDbXref "MSH:C564017", "UMLS:C1838876" ; oboInOwl:id "HP:0009069" ; a owl:Class ; rdfs:label "Lethal infantile mitochondrial myopathy" ; rdfs:subClassOf obo:HP_0003737 . obo:HP_0009071 obo:IAO_0000115 "Chronic muscle inflammation accompanied by muscle weakness." ; oboInOwl:hasDbXref "MSH:D009220", "SNOMEDCT_US:128496001", "SNOMEDCT_US:26889001", "UMLS:C0027121" ; oboInOwl:id "HP:0009071" ; a owl:Class ; rdfs:label "Inflammatory myopathy" ; rdfs:subClassOf obo:HP_0003198 . obo:HP_0009072 obo:IAO_0000115 "Decreased intensity of the Achilles reflex (also known as the ankle jerk reflex), which can be elicited by tapping the tendon is tapped while the foot is dorsiflexed." ; oboInOwl:hasDbXref "UMLS:C1837323" ; oboInOwl:hasExactSynonym "Hyporeflexia at ankle joints" ; oboInOwl:id "HP:0009072" ; a owl:Class ; rdfs:label "Decreased Achilles reflex" ; rdfs:subClassOf obo:HP_0002600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003701 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009073 obo:IAO_0000115 "Lack of strength of the proximal muscles that becomes progressively more severe." ; oboInOwl:hasAlternativeId "HP:0008965" ; oboInOwl:hasDbXref "UMLS:C1836156" ; oboInOwl:hasExactSynonym "Muscle weakness, progressive, proximal" ; oboInOwl:id "HP:0009073" ; a owl:Class ; rdfs:comment "Removed logical definition that used anonymous class. Outstanding term request in UBERON for proximal muscle organ." ; rdfs:label "Progressive proximal muscle weakness" ; rdfs:subClassOf obo:HP_0003323, obo:HP_0003701 . obo:HP_0009077 oboInOwl:hasDbXref "UMLS:C4024601" ; oboInOwl:id "HP:0009077" ; a owl:Class ; rdfs:label "Weakness of long finger extensor muscles" ; rdfs:subClassOf obo:HP_0030237 . obo:HP_0009084 oboInOwl:hasDbXref "UMLS:C1851853" ; oboInOwl:hasExactSynonym "Midline cleft of maxillary alveolar process", "Midline cleft of upper alveolar ridge", "Midline notch of maxillary alveolar process", "Midline notch of maxillary alveolar ridge", "Midline notch of upper gum ridge" ; oboInOwl:id "HP:0009084" ; a owl:Class ; rdfs:label "Midline notch of upper alveolar ridge" ; rdfs:subClassOf obo:HP_0006477 . obo:HP_0009085 obo:IAO_0000115 "Increased width of the alveolar ridges." ; oboInOwl:hasAlternativeId "HP:0009078", "HP:0009083" ; oboInOwl:hasBroadSynonym "Increased size of gum ridge" ; oboInOwl:hasDbXref "UMLS:C1856164", "UMLS:C1865598" ; oboInOwl:hasExactSynonym "Alveolar ridge excess", "Enlarged alveolar ridge", "Hyperplasia of alveolar process of jaw", "Hyperplasia of alveolar ridge", "Increased size of alveolar ridge", "Overgrowth of alveolar ridge", "Overgrowth of gum ridge", "Thick alveolar ridges", "Thickened alveolar ridges" ; oboInOwl:hasRelatedSynonym "Hypertrophied alveolar ridge" ; oboInOwl:id "HP:0009085" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding may or may not be accompanied by increased height of the alveolar ridge. This is not to be confused with Prominent palatal ridges or gingival overgrowth. This distinction of gingival from alveolar ridge overgrowth may be difficult, especially in milder degrees of the finding." ; rdfs:label "Alveolar ridge overgrowth" ; rdfs:subClassOf obo:HP_0006477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009087 oboInOwl:hasDbXref "UMLS:C4024600" ; oboInOwl:hasExactSynonym "Posteriorly placed tongue" ; oboInOwl:id "HP:0009087" ; a owl:Class ; rdfs:label "Posteriorly placed tongue" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0009088 obo:IAO_0000115 "Impairment in the physical production of speech sounds." ; dcterms:contributor , , , ; oboInOwl:hasDbXref "UMLS:C1865313" ; oboInOwl:id "HP:0009088" ; a owl:Class ; rdfs:comment "Speech articulation difficulties can result from abnormalities of the vocal tract (the larynx and the pharyngeal, oral, and nasal cavities)." ; rdfs:label "Speech articulation difficulties" ; rdfs:subClassOf obo:HP_0001608, obo:HP_0002463 . obo:HP_0009090 oboInOwl:consider "HP:0001349" ; oboInOwl:id "HP:0009090" ; a owl:Class ; rdfs:label "obsolete Facial diplegic appearance" ; owl:deprecated true . obo:HP_0009092 oboInOwl:hasDbXref "UMLS:C1854934", "UMLS:C4280407" ; oboInOwl:hasExactSynonym "Increasing size of gum ridge", "Progressive hypertrophy of alveolar process of jaw" ; oboInOwl:hasRelatedSynonym "Increasing overgrowth of gum ridge" ; oboInOwl:id "HP:0009092" ; a owl:Class ; rdfs:label "Progressive alveolar ridge hypertropy" ; rdfs:subClassOf obo:HP_0006477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001818 ] ) ] ] . obo:HP_0009094 oboInOwl:hasDbXref "UMLS:C1849350", "UMLS:C4280404", "UMLS:C4280405", "UMLS:C4280406" ; oboInOwl:hasExactSynonym "Cleft of lower gum ridge", "Notch of lower alveolar ridge", "Notch of lower gum ridge", "Notch of mandibular alveolar ridge" ; oboInOwl:hasNarrowSynonym "Cleft of lower alveolar process", "Cleft of lower gingiva", "Cleft of mandibular alveolar process", "Cleft of mandibular gingiva", "Notch of lower alveolar process", "Notch of mandibular alveolar process" ; oboInOwl:id "HP:0009094" ; a owl:Class ; rdfs:label "Cleft lower alveolar ridge" ; rdfs:subClassOf obo:HP_0010289 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004527 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009098 obo:IAO_0000115 "Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx." ; oboInOwl:hasDbXref "UMLS:C4024599" ; oboInOwl:hasExactSynonym "Chronic oral thrush" ; oboInOwl:id "HP:0009098" ; a owl:Class ; rdfs:label "Chronic oral candidiasis" ; rdfs:subClassOf obo:HP_0002728 . obo:HP_0009099 obo:IAO_0000115 "Cleft palate of the midline of the palate." ; oboInOwl:hasDbXref "UMLS:C1850968" ; oboInOwl:hasExactSynonym "Central cleft palate", "Midline cleft palate" ; oboInOwl:id "HP:0009099" ; a owl:Class ; rdfs:label "Median cleft palate" ; rdfs:subClassOf obo:HP_0000175 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009100 oboInOwl:hasDbXref "UMLS:C1859377" ; oboInOwl:hasExactSynonym "Thick anterior alveolar process of jaw" ; oboInOwl:id "HP:0009100" ; a owl:Class ; rdfs:label "Thick anterior alveolar ridges" ; rdfs:subClassOf obo:HP_0009085 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004528 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009101 obo:IAO_0000115 "A cleft of the lip with overlying mucous membrane." ; oboInOwl:hasDbXref "UMLS:C1839277" ; oboInOwl:hasExactSynonym "Submucous labial cleft" ; oboInOwl:id "HP:0009101" ; a owl:Class ; rdfs:comment "Submucous cleft lip may lead to increased nasal resonance." ; rdfs:label "Submucous cleft lip" ; rdfs:subClassOf obo:HP_0000204 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009102 obo:IAO_0000115 "Anterior open bite is a malocclusion characterized by a gap between the anterior teeth (incisors), that is, by a deficiency in the normal vertical overlap between antagonist incisal edges when the posterior teeth are in occlusion." ; oboInOwl:hasAlternativeId "HP:0200095" ; oboInOwl:hasDbXref "UMLS:C4024598" ; oboInOwl:hasExactSynonym "AOB", "Absence of overlap of anterior upper and lower teeth", "Anterior open bite", "Anterior open bite between upper and lower teeth", "Anterior openbite", "Apertognathia malocclusion", "Gap between upper and lower front teeth when biting" ; oboInOwl:id "HP:0009102" ; a owl:Class ; rdfs:label "Anterior open-bite malocclusion" ; rdfs:subClassOf obo:HP_0000689, obo:HP_0010807 . obo:HP_0009103 dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:40:00Z" ; oboInOwl:hasDbXref "UMLS:C4024597" ; oboInOwl:hasExactSynonym "Absent/small pelvis", "Absent/underdeveloped pelvis" ; oboInOwl:id "HP:0009103" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the pelvis" ; rdfs:subClassOf obo:HP_0002644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002355 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009104 obo:IAO_0000115 "Absence or underdevelopment of the pubic bone." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:41:00Z" ; oboInOwl:hasAlternativeId "HP:0008841" ; oboInOwl:hasDbXref "UMLS:C1849305" ; oboInOwl:hasExactSynonym "Absent/small pubic bones", "Absent/underdeveloped pubic bones", "Hypoplastic/aplastic pubic bones" ; oboInOwl:id "HP:0009104" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the pubic bone" ; rdfs:subClassOf obo:HP_0003172, obo:HP_0009103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001275 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009105 obo:IAO_0000115 "Abnormal ossification (bone tissue formation) affecting the pubic bone, also known as the pubis." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:41:00Z" ; oboInOwl:hasDbXref "UMLS:C4024596", "UMLS:C4280403" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of the pubic bone" ; oboInOwl:id "HP:0009105" ; a owl:Class ; rdfs:label "Abnormal ossification of the pubic bone" ; rdfs:subClassOf obo:HP_0003172, obo:HP_0009106 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001275 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009106 obo:IAO_0000115 "An abnormality of the formation and mineralization of any bone of the bony pelvis." ; dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:42:00Z" ; oboInOwl:hasDbXref "UMLS:C4021525", "UMLS:C4280402" ; oboInOwl:hasExactSynonym "Abnormal ossification involving the bones of the pelvis" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of the pelvis bone" ; oboInOwl:id "HP:0009106" ; a owl:Class ; rdfs:label "Abnormal pelvis bone ossification" ; rdfs:subClassOf obo:HP_0002644, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0007830 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009107 dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:42:00Z" ; oboInOwl:hasDbXref "UMLS:C4024595" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of thigh bone head and neck" ; oboInOwl:id "HP:0009107" ; a owl:Class ; rdfs:label "Abnormal ossification involving the femoral head and neck" ; rdfs:subClassOf obo:HP_0003336, obo:HP_0003366 ; owl:equivalentClass _:genid64239 . obo:HP_0009108 dcterms:creator ; oboInOwl:creation_date "2008-04-04T08:44:00Z" ; oboInOwl:hasDbXref "UMLS:C4024594" ; oboInOwl:hasExactSynonym "Absent/small head and neck of thighbone", "Absent/underdeveloped head and neck of thighbone" ; oboInOwl:id "HP:0009108" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the femoral head and neck" ; rdfs:subClassOf obo:HP_0003366, obo:HP_0005613, obo:HP_0009103 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0008802 obo:HP_0100862 obo:HP_0100863 obo:HP_0100864 ) ] ] . obo:HP_0009109 obo:IAO_0000115 "Interruption of the innervation of the diaphragm." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:41:00Z" ; oboInOwl:hasDbXref "UMLS:C1858529" ; oboInOwl:id "HP:0009109" ; a owl:Class ; rdfs:label "Denervation of the diaphragm" ; rdfs:subClassOf obo:HP_0000775 . obo:HP_0009110 obo:IAO_0000115 "A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:42:00Z" ; oboInOwl:hasAlternativeId "HP:0009114" ; oboInOwl:hasDbXref "MSH:D003965", "SNOMEDCT_US:34168003", "UMLS:C0011981" ; oboInOwl:hasRelatedSynonym "Eventration of the diaphragm" ; oboInOwl:id "HP:0009110" ; a owl:Class ; rdfs:label "Diaphragmatic eventration" ; rdfs:subClassOf obo:HP_0000775 . obo:HP_0009112 obo:IAO_0000115 "Congenital absence of the left half of the diaphragm." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:43:00Z" ; oboInOwl:hasAlternativeId "HP:0040048" ; oboInOwl:hasDbXref "UMLS:C4024593" ; oboInOwl:hasExactSynonym "Absent left hemidiaphragm", "Left diaphragmatic hernia" ; oboInOwl:id "HP:0009112" ; a owl:Class ; rdfs:label "Aplasia of the left hemidiaphragm" ; rdfs:subClassOf obo:HP_0000776, obo:HP_0040046 . obo:HP_0009113 obo:IAO_0000115 "A decrease in the strength of the diaphragm." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:43:00Z" ; oboInOwl:hasAlternativeId "HP:0005953", "HP:0009111" ; oboInOwl:hasDbXref "SNOMEDCT_US:95438009", "UMLS:C0521532", "UMLS:C4020786" ; oboInOwl:hasExactSynonym "Diaphragmatic paraparesis", "Weak diaphragm" ; oboInOwl:hasRelatedSynonym "Diminished diaphragmatic motion" ; oboInOwl:id "HP:0009113" ; a owl:Class ; rdfs:comment "Diaphragmatic paralysis is an extreme form of diaphragmatic weakness. Weakness of the diaphragm can result from abnormalities at any site along its neuromuscular axis, although it most frequently arises from diseases in the phrenic nerves or from myopathies affecting the diaphragm itself. Presence of diaphragmatic weakness may be suspected from the complaint of dyspnea (particularly on exertion) or orthopnea; or the presence of rapid, shallow breathing or, more importantly, paradoxical inward motion of the abdomen during inspiration on physical examination." ; rdfs:label "Diaphragmatic weakness" ; rdfs:subClassOf obo:HP_0001324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009115 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of one or more components of the skeleton." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:53:00Z" ; oboInOwl:hasDbXref "UMLS:C4024592" ; oboInOwl:hasExactSynonym "Absent/small skeleton", "Absent/underdeveloped skeleton" ; oboInOwl:id "HP:0009115" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving the skeleton" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004288 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009116 dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:53:00Z" ; oboInOwl:hasDbXref "UMLS:C4024591" ; oboInOwl:id "HP:0009116" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving bones of the skull" ; rdfs:subClassOf obo:HP_0000929, obo:HP_0009122 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009117 obo:IAO_0000115 "Absence or underdevelopment of the maxilla." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T10:57:00Z" ; oboInOwl:hasDbXref "UMLS:C4024590" ; oboInOwl:hasExactSynonym "Underdevelopment of maxilla", "Underdevelopment of upper jaw bones" ; oboInOwl:id "HP:0009117" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the maxilla" ; rdfs:subClassOf obo:HP_0000326, obo:HP_0009116 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009118 obo:IAO_0000115 "Absence or underdevelopment of the mandible." ; oboInOwl:creation_date "2008-04-05T10:57:00Z" ; oboInOwl:hasDbXref "MSH:D063173", "UMLS:C3494426", "UMLS:C4021371", "UMLS:C4024589", "UMLS:C4280261", "UMLS:C4280401" ; oboInOwl:id "HP:0009118" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the mandible" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0009116 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009119 obo:IAO_0000115 "Absence or underdevelopment of frontal sinus." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:00:00Z" ; oboInOwl:hasDbXref "UMLS:C4024588" ; oboInOwl:hasExactSynonym "Abnormally small frontal sinus" ; oboInOwl:id "HP:0009119" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the frontal sinuses" ; rdfs:subClassOf obo:HP_0002687, obo:HP_0009120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001760 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009120 obo:IAO_0000115 "Absence or underdevelopment of a cranial sinus or sinuses." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:01:00Z" ; oboInOwl:hasDbXref "UMLS:C4024587" ; oboInOwl:id "HP:0009120" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the sinuses" ; rdfs:subClassOf obo:HP_0000245, obo:HP_0009116 . obo:HP_0009121 obo:IAO_0000115 "An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:16:00Z" ; oboInOwl:hasDbXref "UMLS:C4020785", "UMLS:C4024586" ; oboInOwl:hasRelatedSynonym "Abnormality of the axial skeleton" ; oboInOwl:id "HP:0009121" ; a owl:Class ; rdfs:label "Abnormal axial skeleton morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009122 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of bones of the axial skeleton." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4024585" ; oboInOwl:id "HP:0009122" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia affecting bones of the axial skeleton" ; rdfs:subClassOf obo:HP_0009115, obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009123 dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:36:00Z" ; oboInOwl:hasDbXref "UMLS:C4024584" ; oboInOwl:id "HP:0009123" ; a owl:Class ; rdfs:label "Mixed hypo- and hyperpigmentation of the skin" ; rdfs:subClassOf obo:HP_0000953, obo:HP_0001010 . obo:HP_0009124 obo:IAO_0000115 "An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:40:00Z" ; oboInOwl:hasDbXref "UMLS:C4021524" ; oboInOwl:hasExactSynonym "Abnormality of adipose tissue", "Abnormality of fat tissue", "Abnormality of fatty tissue" ; oboInOwl:id "HP:0009124" ; a owl:Class ; rdfs:label "Abnormal adipose tissue morphology" ; rdfs:subClassOf obo:HP_0003549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009125 obo:IAO_0000115 "Degenerative changes of the fat tissue." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:40:00Z" ; oboInOwl:hasDbXref "MSH:D008060", "SNOMEDCT_US:71325002", "UMLS:C0023787" ; oboInOwl:hasExactSynonym "Inability to make and keep healthy fat tissue" ; oboInOwl:id "HP:0009125" ; a owl:Class ; rdfs:label "Lipodystrophy" ; rdfs:subClassOf obo:HP_0009124 . obo:HP_0009126 obo:IAO_0000115 "An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell)." ; dcterms:creator ; oboInOwl:creation_date "2008-04-05T11:43:00Z" ; oboInOwl:hasDbXref "UMLS:C4024583" ; oboInOwl:hasExactSynonym "Increased adipose tissue", "Increased fat tissue" ; oboInOwl:id "HP:0009126" ; a owl:Class ; rdfs:label "Increased adipose tissue" ; rdfs:subClassOf obo:HP_0009025, obo:HP_0009124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009127 dcterms:creator ; oboInOwl:creation_date "2008-04-07T02:00:00Z" ; oboInOwl:hasDbXref "UMLS:C4024582" ; oboInOwl:hasExactSynonym "Abnormal limb muscles", "Muscle issues in the arms and/or legs" ; oboInOwl:id "HP:0009127" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the limbs" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009128 dcterms:creator ; oboInOwl:creation_date "2008-04-07T02:01:00Z" ; oboInOwl:hasDbXref "UMLS:C4024581" ; oboInOwl:hasExactSynonym "Absent/small muscles of extremities", "Absent/underdeveloped muscles of extremities" ; oboInOwl:id "HP:0009128" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the musculature of the extremities" ; rdfs:subClassOf obo:HP_0001460, obo:HP_0009127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004480 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009129 obo:IAO_0000115 "Muscular atrophy involving the muscles of the upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T05:01:00Z" ; oboInOwl:hasAlternativeId "HP:0003471" ; oboInOwl:hasDbXref "UMLS:C4021523" ; oboInOwl:hasExactSynonym "Amyotrophy involving the upper limbs" ; oboInOwl:id "HP:0009129" ; a owl:Class ; rdfs:label "Upper limb amyotrophy" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0003202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009130 obo:IAO_0000115 "Muscular atrophy involving the muscles of the hand." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T05:01:00Z" ; oboInOwl:hasAlternativeId "HP:0006967", "HP:0008934", "HP:0008951", "HP:0009038" ; oboInOwl:hasDbXref "UMLS:C0239830" ; oboInOwl:hasExactSynonym "Amyotrophy involving the musculature of the hand", "Amyotrophy of hand muscles", "Hand muscle degeneration", "Hand muscle wasting", "Hand muscle wasting, bilateral" ; oboInOwl:id "HP:0009130" ; a owl:Class ; rdfs:comment "This term can be used to described bilateral amyotrophy of the musculature of the hand." ; rdfs:label "Hand muscle atrophy" ; rdfs:subClassOf obo:HP_0001421, obo:HP_0007149 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009131 obo:IAO_0000115 "A disease or lesion affecting the muscles of the thorax." ; dcterms:creator ; oboInOwl:creation_date "2008-04-07T05:06:00Z" ; oboInOwl:hasDbXref "UMLS:C4024580" ; oboInOwl:id "HP:0009131" ; a owl:Class ; rdfs:label "Abnormality of the musculature of the thorax" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009132 obo:IAO_0000115 "This term applies to all changes in bone mineral density of the tarsal bones, which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone." ; dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:39:00Z" ; oboInOwl:hasDbXref "UMLS:C4021522" ; oboInOwl:hasExactSynonym "Abnormality of bone mineral density involving tarsal bones" ; oboInOwl:id "HP:0009132" ; a owl:Class ; rdfs:label "Abnormal tarsal bone mineral density" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0004348 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001019 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009134 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:43:00Z" ; oboInOwl:hasDbXref "UMLS:C4024579" ; oboInOwl:id "HP:0009134" ; a owl:Class ; rdfs:label "Osteolysis involving bones of the feet" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0009139 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002797 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009136 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:45:00Z" ; oboInOwl:hasDbXref "UMLS:C4024578" ; oboInOwl:hasExactSynonym "Duplication involving bones of the feet" ; oboInOwl:id "HP:0009136" ; a owl:Class ; rdfs:label "Duplication involving bones of the feet" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009138 obo:IAO_0000115 "An abnormal union between bones or parts of bones lower limbs." ; dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:51:00Z" ; oboInOwl:hasDbXref "UMLS:C4024577" ; oboInOwl:hasExactSynonym "Fusion involving the bones of the lower limbs" ; oboInOwl:id "HP:0009138" ; a owl:Class ; rdfs:label "Synostosis involving bones of the lower limbs" ; rdfs:subClassOf obo:HP_0040069, obo:HP_0100240, obo:HP_0100491 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009139 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4024576" ; oboInOwl:id "HP:0009139" ; a owl:Class ; rdfs:label "Osteolysis involving bones of the lower limbs" ; rdfs:subClassOf obo:HP_0002797, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002797 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009140 dcterms:creator ; oboInOwl:creation_date "2008-04-17T02:54:00Z" ; oboInOwl:hasDbXref "UMLS:C4024575" ; oboInOwl:hasExactSynonym "Fusion involving the bones of the feet" ; oboInOwl:id "HP:0009140" ; a owl:Class ; rdfs:label "Synostosis involving bones of the feet" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0009138 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009141 dcterms:creator ; oboInOwl:creation_date "2008-05-02T12:00:00Z" ; oboInOwl:hasAlternativeId "HP:0009070" ; oboInOwl:hasDbXref "UMLS:C4021521" ; oboInOwl:hasExactSynonym "Depletion of mitochondrial dna in skeletal muscle tissue" ; oboInOwl:id "HP:0009141" ; a owl:Class ; rdfs:label "Depletion of mitochondrial DNA in muscle tissue" ; rdfs:subClassOf obo:HP_0003800 . obo:HP_0009142 dcterms:creator ; oboInOwl:creation_date "2008-05-02T01:23:00Z" ; oboInOwl:hasDbXref "UMLS:C4024574" ; oboInOwl:hasExactSynonym "Duplication of bones involving the upper extremities" ; oboInOwl:id "HP:0009142" ; a owl:Class ; rdfs:label "Duplication of bones involving the upper extremities" ; rdfs:subClassOf obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009144 dcterms:creator ; oboInOwl:creation_date "2008-05-02T01:29:00Z" ; oboInOwl:hasDbXref "UMLS:C4024573" ; oboInOwl:id "HP:0009144" ; a owl:Class ; rdfs:label "Supernumerary bones of the axial skeleton" ; rdfs:subClassOf obo:HP_0009121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009145 obo:IAO_0000115 "Any structural anomaly of a cerebral artery. The cerebral arteries comprise three main pairs of arteries and their branches, which supply the cerebrum of the brain. These are the anterior cerebral artery, the middle cerebral artery, and the posterior cerebral artery." ; dcterms:creator ; oboInOwl:creation_date "2008-05-02T01:39:00Z" ; oboInOwl:hasDbXref "UMLS:C4021520" ; oboInOwl:hasExactSynonym "Abnormality of cerebral artery", "Abnormality of the cerebral arteries" ; oboInOwl:id "HP:0009145" ; a owl:Class ; rdfs:label "Abnormal cerebral artery morphology" ; rdfs:subClassOf obo:HP_0011004, obo:HP_0100659 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009147 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T01:39:32Z" ; oboInOwl:hasDbXref "UMLS:C4024572" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of little finger", "Enlarged end part of the outermost bone of pinkie finger", "Enlarged end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009147" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009385, obo:HP_0010249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009148 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T01:40:08Z" ; oboInOwl:hasDbXref "UMLS:C4024571" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of little finger", "Small end part of the outermost bone of pinkie finger", "Small end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009148" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009390, obo:HP_0010254 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009149 obo:IAO_0000115 "A triangular appearance of the epiphysis of the distal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T01:40:48Z" ; oboInOwl:hasAlternativeId "HP:0009137" ; oboInOwl:hasDbXref "UMLS:C4021519" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the distal phalanx of the 5th finger", "Triangular end part of the outermost bone of little finger", "Triangular end part of the outermost bone of pinkie finger", "Triangular end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009149" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009392, obo:HP_0010256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009150 obo:IAO_0000115 "Abnormality of the proximal phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T02:00:20Z" ; oboInOwl:hasDbXref "UMLS:C4024570" ; oboInOwl:hasExactSynonym "Abnormality of the innermost bone little finger", "Abnormality of the innermost bone pinkie finger", "Abnormality of the innermost bone pinky finger" ; oboInOwl:id "HP:0009150" ; a owl:Class ; rdfs:label "Abnormality of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004213 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009152 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T02:07:27Z" ; oboInOwl:hasDbXref "UMLS:C4024569" ; oboInOwl:hasExactSynonym "Abnormality of end part of little finger bone", "Abnormality of end part of pinkie finger bone", "Abnormality of end part of pinky finger bone" ; oboInOwl:id "HP:0009152" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0004207, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009153 obo:IAO_0000115 "Abnormality of the epiphysis of the proximal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:47:42Z" ; oboInOwl:hasDbXref "UMLS:C4024568" ; oboInOwl:hasExactSynonym "Abnormality of end part of the innermost bone of little finger", "Abnormality of end part of the innermost bone of pinkie finger", "Abnormality of end part of the innermost bone of pinky finger" ; oboInOwl:id "HP:0009153" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009152, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009154 obo:IAO_0000115 "A triangular appearance of the epiphysis of the proximal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasAlternativeId "HP:0009156" ; oboInOwl:hasDbXref "UMLS:C4021518" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the proximal phalanx of the 5th finger", "Triangular end part of the innermost bone of little finger", "Triangular end part of the innermost bone of pinkie finger", "Triangular end part of the innermost bone of pinky finger" ; oboInOwl:id "HP:0009154" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009392, obo:HP_0010278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009155 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the proximal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasDbXref "UMLS:C4020783", "UMLS:C4020784" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of little finger", "Cone-shaped end part of the innermost bone of pinkie finger", "Cone-shaped end part of the innermost bone of pinky finger" ; oboInOwl:hasRelatedSynonym "Angel-shaped epiphysis of the proximal phalanx of the 5th finger", "Cone-shaped epiphysis of the proximal phalanx of the little finger" ; oboInOwl:id "HP:0009155" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009384, obo:HP_0010270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009157 obo:IAO_0000115 "Sclerosis of the epiphysis of the proximal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasDbXref "UMLS:C4020782", "UMLS:C4024567" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of little finger", "Increased bone density of end part of the innermost bone of pinkie finger", "Increased bone density of end part of the innermost bone of pinky finger" ; oboInOwl:hasRelatedSynonym "Ivory epiphysis of the proximal phalanx of the little finger" ; oboInOwl:id "HP:0009157" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009388, obo:HP_0010274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009158 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasDbXref "UMLS:C4024566" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of little finger", "Enlarged end part of the innermost bone of pinkie finger", "Enlarged end part of the innermost bone of pinky finger" ; oboInOwl:id "HP:0009158" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009385 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009159 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasDbXref "UMLS:C4024565" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of little finger", "Small end part of the innermost bone of pinkie finger", "Small end part of the innermost bone of pinky finger" ; oboInOwl:id "HP:0009159" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009390, obo:HP_0010276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009160 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:50:39Z" ; oboInOwl:hasDbXref "UMLS:C4024564" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of little finger", "Absent end part of the innermost bone of pinkie finger", "Absent end part of the innermost bone of pinky finger" ; oboInOwl:id "HP:0009160" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009382, obo:HP_0010268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009161 obo:IAO_0000115 "Absence or underdevelopment (hypoplasia) of the middle phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T05:55:56Z" ; oboInOwl:hasAlternativeId "HP:0006242" ; oboInOwl:hasDbXref "UMLS:C1834034" ; oboInOwl:hasExactSynonym "Absent/hypoplastic middle phalanx of 5th finger", "Absent/small middle bone of pinky finger", "Absent/underdeveloped middle bone of little finger", "Absent/underdeveloped middle bone of pinkie finger", "Absent/underdeveloped middle bone of pinky finger" ; oboInOwl:id "HP:0009161" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009162 obo:IAO_0000115 "Absence of the middle phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-22T06:08:40Z" ; oboInOwl:hasAlternativeId "HP:0005774" ; oboInOwl:hasDbXref "UMLS:C3277750" ; oboInOwl:hasExactSynonym "Absent middle bone of little finger", "Absent middle bone of pinkie finger", "Absent middle bone of pinky finger", "Aplasia of the middle phalanx of the 5th finger" ; oboInOwl:id "HP:0009162" ; a owl:Class ; rdfs:label "Absent middle phalanx of 5th finger" ; rdfs:subClassOf obo:HP_0009161, obo:HP_0009238, obo:HP_0010239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009163 oboInOwl:consider "HP:0004207" ; oboInOwl:id "HP:0009163" ; a owl:Class ; rdfs:label "obsolete Abnormal form of the 5th finger" ; owl:deprecated true . obo:HP_0009164 dcterms:creator ; oboInOwl:creation_date "2008-12-22T06:53:39Z" ; oboInOwl:hasAlternativeId "HP:0006154" ; oboInOwl:hasDbXref "UMLS:C1968592" ; oboInOwl:hasExactSynonym "Abnormal calcification of the wrist bones", "Carpal calcifications" ; oboInOwl:id "HP:0009164" ; a owl:Class ; rdfs:label "Abnormal calcification of the carpal bones" ; rdfs:subClassOf obo:HP_0006257, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009165 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:07:42Z" ; oboInOwl:hasDbXref "UMLS:C4024563" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the outermost bone of little finger", "Speckled calcifications in end part of the outermost bone of pinkie finger", "Speckled calcifications in end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009165" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009391, obo:HP_0010255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009166 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:14:33Z" ; oboInOwl:hasDbXref "UMLS:C4024562" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the outermost bone of little finger", "Fragmentation of end part of the outermost bone of pinkie finger", "Fragmentation of end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009166" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009386, obo:HP_0010250 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009167 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:18:06Z" ; oboInOwl:hasDbXref "UMLS:C4024561" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of little finger", "Irregular end part of the outermost bone of pinkie finger", "Irregular end part of the outermost bone of pinky finger" ; oboInOwl:id "HP:0009167" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009387, obo:HP_0010251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009168 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 5th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:44:53Z" ; oboInOwl:hasDbXref "UMLS:C4024560" ; oboInOwl:hasExactSynonym "Bullet-shaped middle little finger bone", "Bullet-shaped middle pinkie finger bone", "Bullet-shaped middle pinky finger bone" ; oboInOwl:id "HP:0009168" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009375, obo:HP_0009845 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009169 obo:IAO_0000115 "Increased width of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:49:04Z" ; oboInOwl:hasDbXref "UMLS:C4021517" ; oboInOwl:hasExactSynonym "Broad middle bone of little finger", "Broad middle bone of pinkie finger", "Broad middle bone of pinky finger", "Wide middle phalanx of the 5th finger" ; oboInOwl:id "HP:0009169" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009374, obo:HP_0009844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009170 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T02:51:32Z" ; oboInOwl:hasDbXref "UMLS:C4024559" ; oboInOwl:id "HP:0009170" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004216, obo:HP_0004219, obo:HP_0009847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009171 obo:IAO_0000115 "A triangular appearance of the epiphyses of the metacarpals. Thess epiphyses are located at the distal end of the metacarpals." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4024558" ; oboInOwl:hasExactSynonym "Triangular end part of the long bone of hand" ; oboInOwl:id "HP:0009171" ; a owl:Class ; rdfs:label "Triangular epiphyses of the metacarpals" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009172 obo:IAO_0000115 "Abnormality of the phalanges of the 4th (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T04:18:24Z" ; oboInOwl:hasAlternativeId "HP:0004191" ; oboInOwl:hasDbXref "UMLS:C4021516" ; oboInOwl:hasExactSynonym "Abnormal bones of 4th finger", "Abnormality of the phalanges of the ring finger" ; oboInOwl:id "HP:0009172" ; a owl:Class ; rdfs:label "Abnormal 4th finger phalanx morphology" ; rdfs:subClassOf obo:HP_0004188, obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009173 obo:IAO_0000115 "Curved appearance of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:05:04Z" ; oboInOwl:hasDbXref "UMLS:C4024557" ; oboInOwl:hasExactSynonym "Curved middle bone of little finger", "Curved middle bone of pinkie finger", "Curved middle bone of pinky finger" ; oboInOwl:id "HP:0009173" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004214, obo:HP_0004219, obo:HP_0009846 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009174 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T04:23:43Z" ; oboInOwl:hasDbXref "UMLS:C4024556" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the ring finger" ; oboInOwl:id "HP:0009174" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0004188, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009175 obo:IAO_0000115 "Patchy increase in bone density of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:10:34Z" ; oboInOwl:hasDbXref "UMLS:C4024555" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the little finger", "Uneven increase in bone density in the middle bone of the pinkie finger", "Uneven increase in bone density in the middle bone of the pinky finger" ; oboInOwl:id "HP:0009175" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009377, obo:HP_0009848, obo:HP_0100907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009177 obo:IAO_0000115 "Fusion of the proximal and middle phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:17:08Z" ; oboInOwl:hasAlternativeId "HP:0005835", "HP:0006025", "HP:0009235" ; oboInOwl:hasDbXref "UMLS:C1836212" ; oboInOwl:hasExactSynonym "Fused innermost and middle bones of little finger", "Fused innermost and middle bones of pinkie finger", "Fused innermost and middle bones of pinky finger", "Proximal 5th finger symphalangism", "Proximal fifth finger symphalangism", "Symphalangism of the proximal and middle phalanges of the 5th finger" ; oboInOwl:id "HP:0009177" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 5th finger" ; rdfs:subClassOf obo:HP_0006152, obo:HP_0009178, obo:HP_0009232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009178 obo:IAO_0000115 "Fusion of the middle phalanx of the 5th finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:17:43Z" ; oboInOwl:hasDbXref "UMLS:C4024554" ; oboInOwl:hasExactSynonym "Fused middle bones of little finger", "Fused middle bones of pinkie finger", "Fused middle bones of pinky finger" ; oboInOwl:id "HP:0009178" ; a owl:Class ; rdfs:label "Symphalangism of middle phalanx of 5th finger" ; rdfs:subClassOf obo:HP_0004218, obo:HP_0004219, obo:HP_0009849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009179 obo:IAO_0000115 "Displacement of the 5th finger from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:29:20Z" ; oboInOwl:hasAlternativeId "HP:0006036" ; oboInOwl:hasDbXref "UMLS:C4021515" ; oboInOwl:hasExactSynonym "Displaced little finger", "Displaced pinkie finger", "Displaced pinky finger", "Laterally displaced fifth finger" ; oboInOwl:id "HP:0009179" ; a owl:Class ; rdfs:label "Deviation of the 5th finger" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0004207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009180 obo:IAO_0000115 "Displacement of the 5th finger towards the ulnar side." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T03:30:05Z" ; oboInOwl:hasDbXref "UMLS:C4024553" ; oboInOwl:id "HP:0009180" ; a owl:Class ; rdfs:label "Ulnar deviation of the 5th finger" ; rdfs:subClassOf obo:HP_0009179, obo:HP_0009465 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009182 obo:IAO_0000115 "Triangular shaped middle phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T04:05:33Z" ; oboInOwl:hasDbXref "UMLS:C4024552" ; oboInOwl:hasExactSynonym "Triangular shaped middle little finger bone", "Triangular shaped middle pinkie finger bone", "Triangular shaped middle pinky finger bone" ; oboInOwl:id "HP:0009182" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009378, obo:HP_0009850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009183 obo:IAO_0000115 "Chronic loss of joint motion in the 5th finger due to structural changes in non-bony tissue. The term camptodactyly of the 5th finger is used if the distal and/or proximal interphalangeal joints are affected." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T04:11:30Z" ; oboInOwl:hasAlternativeId "HP:0001184" ; oboInOwl:hasDbXref "UMLS:C1865702" ; oboInOwl:hasRelatedSynonym "5th finger camptodactyly", "Fifth finger camptodactyly" ; oboInOwl:id "HP:0009183" ; a owl:Class ; rdfs:label "Joint contracture of the 5th finger" ; rdfs:subClassOf obo:HP_0004207, obo:HP_0012785 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009184 obo:IAO_0000115 "Chronic loss of joint motion of the distal interphalangeal joint of the 5th finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T04:16:15Z" ; oboInOwl:hasDbXref "UMLS:C4024551" ; oboInOwl:id "HP:0009184" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 5th finger" ; rdfs:subClassOf obo:HP_0009183, obo:HP_0009697 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009185 obo:IAO_0000115 "Proximal interphalangeal (PIP) flexion deformity of the little finger. That is, the PIP joint of a little finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T04:16:58Z" ; oboInOwl:hasAlternativeId "HP:0005047", "HP:0006062" ; oboInOwl:hasDbXref "UMLS:C3554612" ; oboInOwl:id "HP:0009185" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 5th finger" ; rdfs:subClassOf obo:HP_0009183, obo:HP_0100490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009186 obo:IAO_0000115 "Chronic loss of joint motion of the metacarpophalangeal joint of the 5th finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2008-12-29T04:18:00Z" ; oboInOwl:hasDbXref "UMLS:C4024550" ; oboInOwl:id "HP:0009186" ; a owl:Class ; rdfs:label "Contracture of the metacarpophalangeal joint of the 5th finger" ; rdfs:subClassOf obo:HP_0009183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007747 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009187 obo:IAO_0000115 "An abnormality of the distal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T12:07:32Z" ; oboInOwl:hasDbXref "UMLS:C4024549" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost little finger bone", "Bracket shaped end part of the outermost pinkie finger bone", "Bracket shaped end part of the outermost pinky finger bone" ; oboInOwl:id "HP:0009187" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009383, obo:HP_0010247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009188 obo:IAO_0000115 "A secondary ossification center in the distal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T12:28:19Z" ; oboInOwl:hasDbXref "UMLS:C4024548" ; oboInOwl:id "HP:0009188" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009198, obo:HP_0009389, obo:HP_0010253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009189 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the metacarpals." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4024547" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the long bone of hand" ; oboInOwl:id "HP:0009189" ; a owl:Class ; rdfs:label "Fragmentation of the metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0003841, obo:HP_0005913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009190 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the metacarpals." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4024546" ; oboInOwl:hasExactSynonym "Irregular end part of the long bone of hand" ; oboInOwl:id "HP:0009190" ; a owl:Class ; rdfs:label "Irregular epiphyses of the metacarpals" ; rdfs:subClassOf obo:HP_0003842, obo:HP_0005913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009191 obo:IAO_0000115 "Sclerosis of the epiphyses of the metacarpals, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4024545" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the long bone of hands" ; oboInOwl:id "HP:0009191" ; a owl:Class ; rdfs:label "Ivory epiphyses of the metacarpals" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010583, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009192 obo:IAO_0000115 "Absence or underdevelopment (hypoplasia) of the proximal phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:57:28Z" ; oboInOwl:hasDbXref "UMLS:C4024544" ; oboInOwl:hasExactSynonym "Absent/small innermost little finger bone", "Absent/small innermost pinkie finger bone", "Absent/small innermost pinky finger bone", "Absent/underdeveloped innermost pinky finger bone" ; oboInOwl:id "HP:0009192" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009193 obo:IAO_0000115 "A pseudoepiphysis is a secondary ossification center distinct from the normal epiphysis. The normal metacarpal epiphyses are located at the distal ends of the metacarpal bones. Accessory epiphyses (which are also known as pseudoepiphyses) can also occasionally be observed at the proximal ends of the metacarpals, usually involving the 2nd metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasAlternativeId "HP:0006091", "HP:0006164" ; oboInOwl:hasDbXref "UMLS:C1860253" ; oboInOwl:hasExactSynonym "Accessory proximal metacarpal ossification centers", "Accessory proximal metacarpal ossification centres", "Metacarpal pseudoepiphyses" ; oboInOwl:id "HP:0009193" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the metacarpals" ; rdfs:subClassOf obo:HP_0004288, obo:HP_0005913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010355 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009194 obo:IAO_0000115 "Abnormally small size of the epiphyses located at the distal end of the metacarpals in respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4024543" ; oboInOwl:hasExactSynonym "Small end part of the long bone of hand" ; oboInOwl:id "HP:0009194" ; a owl:Class ; rdfs:label "Small epiphyses of the metacarpals" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009195 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the metacarpals." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4021514" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the long bone of hand", "Stippling of the epiphyses of the metacarpals" ; oboInOwl:id "HP:0009195" ; a owl:Class ; rdfs:label "Epiphyseal stippling of the metacarpals" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010655, obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009196 obo:IAO_0000115 "Absence of the epiphyses of the metacarpal bones, which are normally located at the distal ends of the metacarpals." ; dcterms:creator ; oboInOwl:creation_date "2008-12-30T02:03:34Z" ; oboInOwl:hasAlternativeId "HP:0006013" ; oboInOwl:hasDbXref "UMLS:C4021513" ; oboInOwl:hasExactSynonym "Absent end part of the long bone of hand", "Absent metacarpal ossification center", "Absent metacarpal ossification centre" ; oboInOwl:id "HP:0009196" ; a owl:Class ; rdfs:label "Absent metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009197 obo:IAO_0000115 "An abnormality of the proximal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:05:01Z" ; oboInOwl:hasDbXref "UMLS:C4024542" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of the little finger", "Bracket shaped end part of the innermost bone of the pinkie finger", "Bracket shaped end part of the innermost bone of the pinky finger" ; oboInOwl:id "HP:0009197" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009383, obo:HP_0010269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009198 obo:IAO_0000115 "Abnormality of the epiphysis of the distal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T04:41:32Z" ; oboInOwl:hasAlternativeId "HP:0004228" ; oboInOwl:hasDbXref "UMLS:C4021512" ; oboInOwl:hasExactSynonym "Abnormality of end part of the outermost bone of the little finger", "Abnormality of end part of the outermost bone of the pinkie finger", "Abnormality of end part of the outermost bone of the pinky finger", "Abnormality of the epiphysis of the terminal phalanx of the little finger" ; oboInOwl:id "HP:0009198" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009152, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009199 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:09:06Z" ; oboInOwl:hasDbXref "UMLS:C4024541" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost little finger bone", "Irregular end part of the innermost pinkie finger bone", "Irregular end part of the innermost pinky finger bone" ; oboInOwl:id "HP:0009199" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009387, obo:HP_0010273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009200 obo:IAO_0000115 "A secondary ossification center in the proximal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:10:13Z" ; oboInOwl:hasDbXref "UMLS:C4024540" ; oboInOwl:id "HP:0009200" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009389, obo:HP_0010275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009201 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:11:42Z" ; oboInOwl:hasDbXref "UMLS:C4024539" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the innnermost bone of the little finger", "Speckled calcifications in end part of the innnermost bone of the pinkie finger", "Speckled calcifications in end part of the innnermost bone of the pinky finger" ; oboInOwl:id "HP:0009201" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009391, obo:HP_0010277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009202 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:13:41Z" ; oboInOwl:hasDbXref "UMLS:C4024538" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the innermost bone of the little finger", "Fragmentation of end part of the innermost bone of the pinkie finger", "Fragmentation of end part of the innermost bone of the pinky finger" ; oboInOwl:id "HP:0009202" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009153, obo:HP_0009386, obo:HP_0010272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009203 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024537" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the little finger", "Absent end part of the middle bone of the pinkie finger", "Absent end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009203" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009382, obo:HP_0010257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009204 obo:IAO_0000115 "An abnormality of the middle phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024536" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the little finger", "Bracket shaped end part of the middle bone of the pinkie finger", "Bracket shaped end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009204" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009383, obo:HP_0010258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009205 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the middle phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024535" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the little finger", "Cone-shaped end part of the middle bone of the pinkie finger", "Cone-shaped end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009205" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009384, obo:HP_0010259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009206 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024534" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the little finger", "Enlarged end part of the middle bone of the pinkie finger", "Enlarged end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009206" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009385, obo:HP_0010260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009207 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024533" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the middle bone of the little finger", "Fragmentation of end part of the middle bone of the pinkie finger", "Fragmentation of end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009207" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009386, obo:HP_0010261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009208 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024532" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the little finger", "Irregular end part of the middle bone of the pinkie finger", "Irregular end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009208" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009387, obo:HP_0010262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009209 obo:IAO_0000115 "Sclerosis of the epiphysis of the middle phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024531" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of little finger", "Increased bone density of end part of the middle bone of pinkie finger", "Increased bone density of end part of the middle bone of pinky finger" ; oboInOwl:id "HP:0009209" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009388, obo:HP_0010263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009210 obo:IAO_0000115 "A secondary ossification center in the middle phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024530" ; oboInOwl:id "HP:0009210" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009389, obo:HP_0010264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009211 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024529" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the little finger", "Small end part of the middle bone of the pinkie finger", "Small end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009211" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009390, obo:HP_0010265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009212 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4024528" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the middle bone of the little finger", "Speckled calcifications in end part of the middle bone of the pinkie finger", "Speckled calcifications in end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009212" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009391, obo:HP_0010266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009213 obo:IAO_0000115 "A triangular appearance of the epiphysis of the middle phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4021511" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the middle phalanx of the 5th finger", "Triangular end part of the middle bone of the little finger", "Triangular end part of the middle bone of the pinkie finger", "Triangular end part of the middle bone of the pinky finger" ; oboInOwl:id "HP:0009213" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004224, obo:HP_0009392, obo:HP_0010267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009214 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024527" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009214" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009393, obo:HP_0010257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009215 obo:IAO_0000115 "An abnormality of the middle phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024526" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009215" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009394, obo:HP_0010258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009216 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the middle phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024525" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009216" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009395, obo:HP_0010259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009217 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024524" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009217" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009396, obo:HP_0010260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009218 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024523" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009218" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009397, obo:HP_0010261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009219 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024522" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009219" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009398, obo:HP_0010262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009220 obo:IAO_0000115 "Sclerosis of the epiphysis of the middle phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024521" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle ring finger bone" ; oboInOwl:id "HP:0009220" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009399, obo:HP_0010263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009221 obo:IAO_0000115 "A secondary ossification center in the middle phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024520" ; oboInOwl:id "HP:0009221" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009400, obo:HP_0010264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009222 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024519" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009222" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009401, obo:HP_0010265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009223 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4024518" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009223" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009402, obo:HP_0010266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009224 obo:IAO_0000115 "A triangular appearance of the epiphysis of the middle phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T05:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4021510" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the middle phalanx of the 4th finger", "Triangular end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009224" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009247, obo:HP_0009403, obo:HP_0010267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009225 obo:IAO_0000115 "Absence of the proximal phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:00:33Z" ; oboInOwl:hasDbXref "UMLS:C4024517" ; oboInOwl:hasExactSynonym "Absent innermost bone of little finger", "Absent innermost bone of pinkie finger", "Absent innermost bone of pinky finger" ; oboInOwl:id "HP:0009225" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009192, obo:HP_0009238, obo:HP_0010242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009226 obo:IAO_0000115 "Hypoplastic/small proximal phalanx of the fifth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:01:34Z" ; oboInOwl:hasDbXref "UMLS:C4021509" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 5th finger", "Short innermost little finger bone", "Short innermost pinkie finger bone", "Short innermost pinky finger bone", "Short proximal phalanx of the fifth finger" ; oboInOwl:id "HP:0009226" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009192, obo:HP_0009237, obo:HP_0010241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009227 obo:IAO_0000115 "Increased width of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4021508" ; oboInOwl:hasExactSynonym "Broad innermost little finger bone", "Broad innermost pinkie finger bone", "Broad innermost pinky finger bone", "Wide proximal phalanx of the 5th finger" ; oboInOwl:id "HP:0009227" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009374, obo:HP_0009852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009228 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 5th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024516" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost little finger bone", "Bullet-shaped innermost pinkie finger bone", "Bullet-shaped innermost pinky finger bone" ; oboInOwl:id "HP:0009228" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009375, obo:HP_0009853 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009229 obo:IAO_0000115 "Curved appearance of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024515" ; oboInOwl:hasExactSynonym "Curved innermost bone of little finger", "Curved innermost bone of pinkie finger", "Curved innermost bone of pinky finger" ; oboInOwl:id "HP:0009229" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004214, obo:HP_0009150, obo:HP_0009854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009230 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024514" ; oboInOwl:id "HP:0009230" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004216, obo:HP_0009150, obo:HP_0009855 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009231 obo:IAO_0000115 "Patchy increase in bone density of the proximal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024513" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of little finger", "Uneven increase in bone density in the innermost bone of pinkie finger", "Uneven increase in bone density in the innermost bone of pinky finger" ; oboInOwl:id "HP:0009231" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009377, obo:HP_0009856, obo:HP_0100911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009232 obo:IAO_0000115 "Fusion of the proximal phalanx of the 5th finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024512" ; oboInOwl:hasExactSynonym "Fused innermost bone of little finger", "Fused innermost bone of pinkie finger", "Fused innermost bone of pinky finger" ; oboInOwl:id "HP:0009232" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004218, obo:HP_0009150, obo:HP_0009857 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009233 obo:IAO_0000115 "Triangular shaped proximal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4024511" ; oboInOwl:hasExactSynonym "Triangular shaped innermost little finger bone", "Triangular shaped innermost pinkie finger bone", "Triangular shaped innermost pinky finger bone" ; oboInOwl:id "HP:0009233" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009378, obo:HP_0009858 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009234 obo:IAO_0000115 "Fusion of the proximal phalanx of the 5th finger with the 5th metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:19:01Z" ; oboInOwl:hasDbXref "UMLS:C4024510" ; oboInOwl:hasExactSynonym "Fused innermost bone of little finger with 5th long bone of hand", "Fused innermost bone of pinkie finger with 5th long bone of hand", "Fused innermost bone of pinky finger with 5th long bone of hand" ; oboInOwl:id "HP:0009234" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 5th finger with the 5th metacarpal" ; rdfs:subClassOf obo:HP_0005880, obo:HP_0009232, obo:HP_0009708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009236 obo:IAO_0000115 "Rhomboid or triangular shaped 5th (little) finger proximal phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:20:38Z" ; oboInOwl:hasDbXref "UMLS:C4024509" ; oboInOwl:hasExactSynonym "Rhomboid or triangular shaped innermost bone of little finger", "Rhomboid or triangular shaped innermost bone of pinkie finger", "Rhomboid or triangular shaped innermost bone of pinky finger" ; oboInOwl:id "HP:0009236" ; a owl:Class ; rdfs:label "Rhomboid or triangular shaped 5th finger proximal phalanx" ; rdfs:subClassOf obo:HP_0009233 . obo:HP_0009237 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T06:54:07Z" ; oboInOwl:hasAlternativeId "HP:0001205", "HP:0004208", "HP:0004210", "HP:0004211", "HP:0004215", "HP:0004217", "HP:0005804", "HP:0005888" ; oboInOwl:hasDbXref "UMLS:C1842878" ; oboInOwl:hasExactSynonym "Fifth finger brachydactyly", "Hypoplastic phalanges of the little finger", "Hypoplastic/small 5th finger", "Hypoplastic/small little finger", "Short 5th finger", "Short fifth finger", "Short fifth fingers", "Short little finger", "Short phalanges of the little finger", "Short pinkie finger", "Short pinky finger" ; oboInOwl:id "HP:0009237" ; a owl:Class ; rdfs:label "Short 5th finger" ; rdfs:subClassOf obo:HP_0006262, obo:HP_0009381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009238 obo:IAO_0000115 "Absent 5th (little) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:02:48Z" ; oboInOwl:hasDbXref "UMLS:C4024508" ; oboInOwl:hasExactSynonym "Absent little finger", "Absent pinkie finger", "Absent pinky finger" ; oboInOwl:id "HP:0009238" ; a owl:Class ; rdfs:label "Aplasia of the 5th finger" ; rdfs:subClassOf obo:HP_0006262, obo:HP_0009380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009239 dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024507" ; oboInOwl:hasExactSynonym "Absent/small outermost bone of little finger", "Absent/small outermost bone of pinkie finger", "Absent/small outermost bone of pinky finger", "Absent/underdeveloped outermost bone of pinky finger" ; oboInOwl:id "HP:0009239" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009240 obo:IAO_0000115 "Increased width of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024506" ; oboInOwl:hasExactSynonym "Broad outermost little finger bone", "Broad outermost pinkie finger bone", "Broad outermost pinky finger bone", "Wide outermost pinky finger bone" ; oboInOwl:id "HP:0009240" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009374, obo:HP_0009836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009241 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 5th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024505" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost little finger bone", "Bullet-shaped outermost pinkie finger bone", "Bullet-shaped outermost pinky finger bone" ; oboInOwl:id "HP:0009241" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009375, obo:HP_0009837 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009242 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024504" ; oboInOwl:id "HP:0009242" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004216, obo:HP_0004225, obo:HP_0009839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009243 obo:IAO_0000115 "Patchy increase in bone density of the distal phalanx of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024503" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of little finger", "Uneven increase in bone density in the outermost bone of pinkie finger", "Uneven increase in bone density in the outermost bone of pinky finger" ; oboInOwl:id "HP:0009243" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009377, obo:HP_0009840, obo:HP_0100903 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009244 obo:IAO_0000115 "Fusion of the terminal/distal and middle phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasAlternativeId "HP:0006250", "HP:0009176" ; oboInOwl:hasDbXref "UMLS:C1868573", "UMLS:C4020781" ; oboInOwl:hasExactSynonym "Fifth finger distal interphalangeal joint symphalangism", "Fused end and middle bones of little finger", "Fused end and middle bones of pinkie finger", "Fused end and middle bones of pinky finger", "Symphalangism of the distal and middle phalanges of the 5th finger", "Symphalangism of the terminal and middle phalanges of the 5th finger" ; oboInOwl:hasRelatedSynonym "Fusion of the terminal and middle phalanges of the 5th finger" ; oboInOwl:id "HP:0009244" ; a owl:Class ; rdfs:label "Distal/middle symphalangism of 5th finger" ; rdfs:subClassOf obo:HP_0001204, obo:HP_0004225, obo:HP_0009178 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009245 obo:IAO_0000115 "Triangular shaped distal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4024502" ; oboInOwl:hasExactSynonym "Triangular shaped outermost little finger bone", "Triangular shaped outermost pinkie finger bone", "Triangular shaped outermost pinky finger bone" ; oboInOwl:id "HP:0009245" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009378, obo:HP_0009875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009246 obo:IAO_0000115 "Absence of the distal phalanx of the little (5th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-05T07:27:52Z" ; oboInOwl:hasDbXref "UMLS:C4024501" ; oboInOwl:hasExactSynonym "Absent outermost little finger bone", "Absent outermost pinkie finger bone", "Absent outermost pinky finger bone" ; oboInOwl:id "HP:0009246" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009238, obo:HP_0009239, obo:HP_0009881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009247 dcterms:creator ; oboInOwl:creation_date "2009-01-07T11:29:14Z" ; oboInOwl:hasDbXref "UMLS:C4024500" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle bone of the ring finger" ; oboInOwl:id "HP:0009247" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0009283, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009248 dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:04:09Z" ; oboInOwl:hasDbXref "UMLS:C4024499" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009248" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0009284, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009249 dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:04:09Z" ; oboInOwl:hasDbXref "UMLS:C4024498" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009249" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0009282, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009250 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024497" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009250" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009393, obo:HP_0010246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009251 obo:IAO_0000115 "An abnormality of the distal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024496" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009251" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009394, obo:HP_0010247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009252 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the distal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024495" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009252" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009395, obo:HP_0010248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009253 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024494" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009253" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009396, obo:HP_0010249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009254 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024493" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009254" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009397, obo:HP_0010250 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009255 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024492" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009255" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009398, obo:HP_0010251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009256 obo:IAO_0000115 "Sclerosis of the epiphysis of the distal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024491" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost ring finger bone" ; oboInOwl:id "HP:0009256" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009399, obo:HP_0010252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009257 obo:IAO_0000115 "A secondary ossification center in the distal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024490" ; oboInOwl:id "HP:0009257" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009400, obo:HP_0010253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009258 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024489" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009258" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009401, obo:HP_0010254 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009259 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4024488" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009259" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009402, obo:HP_0010255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009260 obo:IAO_0000115 "A triangular appearance of the epiphysis of the distal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4021507" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the distal phalanx of the 4th finger", "Triangular end part of the outermost bone of ring finger" ; oboInOwl:id "HP:0009260" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009249, obo:HP_0009403, obo:HP_0010256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009261 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024487" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009261" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009393, obo:HP_0010268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009262 obo:IAO_0000115 "An abnormality of the proximal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasAlternativeId "HP:0004200" ; oboInOwl:hasDbXref "UMLS:C4021506" ; oboInOwl:hasExactSynonym "Bracket proximal epiphysis of the ring finger", "Bracket shaped end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009262" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009394, obo:HP_0010269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009263 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the proximal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024486" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009263" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009395, obo:HP_0010270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009264 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024485" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009264" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009396, obo:HP_0010271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009265 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024484" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009265" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009397, obo:HP_0010272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009266 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024483" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009266" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009398, obo:HP_0010273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009267 obo:IAO_0000115 "Sclerosis of the epiphysis of the proximal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024482" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost ring finger bone" ; oboInOwl:id "HP:0009267" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009399, obo:HP_0010274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009268 obo:IAO_0000115 "A secondary ossification center in the proximal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024481" ; oboInOwl:id "HP:0009268" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009400, obo:HP_0010275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009269 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024480" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009269" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009401, obo:HP_0010276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009270 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4024479" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the innermost bone of ring finger" ; oboInOwl:id "HP:0009270" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009402, obo:HP_0010277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009271 obo:IAO_0000115 "A triangular appearance of the epiphysis of the proximal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T12:12:59Z" ; oboInOwl:hasDbXref "UMLS:C4021505" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the proximal phalanx of the 4th finger", "Triangular end part of the innermost bone of ring finger" ; oboInOwl:id "HP:0009271" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009248, obo:HP_0009403, obo:HP_0010278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009272 obo:IAO_0000115 "A small/hypoplastic or absent/aplastic 4th (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:01:26Z" ; oboInOwl:hasDbXref "UMLS:C4024478" ; oboInOwl:hasExactSynonym "Absent/small ring finger bone", "Absent/underdeveloped ring finger bone" ; oboInOwl:id "HP:0009272" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 4th finger" ; rdfs:subClassOf obo:HP_0004188, obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009273 obo:IAO_0000115 "Displacement of the 4th finger from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:03:23Z" ; oboInOwl:hasDbXref "UMLS:C4024477" ; oboInOwl:hasExactSynonym "Deviation of the ring finger" ; oboInOwl:id "HP:0009273" ; a owl:Class ; rdfs:label "Deviation of the 4th finger" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0004188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009274 obo:IAO_0000115 "Chronic loss of joint motion in the 4th finger due to structural changes in non-bony tissue. The term camptodactyly of the 4th finger is used if the distal and/or proximal interphalangeal joints are affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:04:54Z" ; oboInOwl:hasAlternativeId "HP:0004189" ; oboInOwl:hasDbXref "UMLS:C4021504" ; oboInOwl:hasExactSynonym "Joint contractures of the fourth finger" ; oboInOwl:id "HP:0009274" ; a owl:Class ; rdfs:label "Joint contracture of the 4th finger" ; rdfs:subClassOf obo:HP_0004188, obo:HP_0012785 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009275 obo:IAO_0000115 "Chronic loss of joint motion of the distal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:10:39Z" ; oboInOwl:hasDbXref "UMLS:C4024476" ; oboInOwl:id "HP:0009275" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 4th finger" ; rdfs:subClassOf obo:HP_0009274, obo:HP_0009697 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014670 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009276 obo:IAO_0000115 "Chronic loss of joint motion of the proximal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue. That is, the PIP joint of a fourth finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:10:39Z" ; oboInOwl:hasAlternativeId "HP:0005845" ; oboInOwl:hasDbXref "UMLS:C4021503" ; oboInOwl:hasExactSynonym "4th finger camptodactyly", "Camptodactyly of the 4th finger", "Camptodactyly of the ring finger" ; oboInOwl:id "HP:0009276" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 4th finger" ; rdfs:subClassOf obo:HP_0009274, obo:HP_0100490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009277 obo:IAO_0000115 "Chronic loss of joint motion of the metacarpophalangeal joint of the 4th finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:10:39Z" ; oboInOwl:hasDbXref "UMLS:C4024475" ; oboInOwl:id "HP:0009277" ; a owl:Class ; rdfs:label "Contracture of the metacarpophalangeal joint of the 4th finger" ; rdfs:subClassOf obo:HP_0009274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007744 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009278 obo:IAO_0000115 "Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:24:53Z" ; oboInOwl:hasDbXref "UMLS:C4024474" ; oboInOwl:hasExactSynonym "Ulnar deviation of the ring finger" ; oboInOwl:id "HP:0009278" ; a owl:Class ; rdfs:label "Ulnar deviation of the 4th finger" ; rdfs:subClassOf obo:HP_0009273, obo:HP_0009465 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009279 obo:IAO_0000115 "Displacement of the 4th finger towards the radial side (i.e., towards the thumb)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:24:53Z" ; oboInOwl:hasDbXref "UMLS:C4024473" ; oboInOwl:hasExactSynonym "Radial deviation of the ring finger" ; oboInOwl:id "HP:0009279" ; a owl:Class ; rdfs:label "Radial deviation of the 4th finger" ; rdfs:subClassOf obo:HP_0009273, obo:HP_0009466 . obo:HP_0009280 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the fourth finger, also known as the ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:28:08Z" ; oboInOwl:hasAlternativeId "HP:0004190", "HP:0006211" ; oboInOwl:hasDbXref "UMLS:C4021502" ; oboInOwl:hasExactSynonym "Hypoplastic/small 4th finger", "Short ring finger" ; oboInOwl:id "HP:0009280" ; a owl:Class ; rdfs:label "Short 4th finger" ; rdfs:subClassOf obo:HP_0009272, obo:HP_0009381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009281 obo:IAO_0000115 "Absent 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:28:08Z" ; oboInOwl:hasDbXref "UMLS:C4024472" ; oboInOwl:hasExactSynonym "Absent ring finger" ; oboInOwl:id "HP:0009281" ; a owl:Class ; rdfs:label "Aplasia of the 4th finger" ; rdfs:subClassOf obo:HP_0009272, obo:HP_0009380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009282 dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:42:40Z" ; oboInOwl:hasDbXref "UMLS:C4024471" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of ring finger" ; oboInOwl:id "HP:0009282" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009283 dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:42:40Z" ; oboInOwl:hasAlternativeId "HP:0004204" ; oboInOwl:hasDbXref "UMLS:C4021501" ; oboInOwl:hasExactSynonym "Abnormal middle bone of ring finger", "Abnormality of the middle phalanx of the ring finger" ; oboInOwl:id "HP:0009283" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009284 dcterms:creator ; oboInOwl:creation_date "2009-01-07T04:42:40Z" ; oboInOwl:hasAlternativeId "HP:0004199" ; oboInOwl:hasDbXref "UMLS:C4021500" ; oboInOwl:hasExactSynonym "Abnormal innermost bone of ring finger", "Abnormality of the proximal phalanx of the ring finger" ; oboInOwl:id "HP:0009284" ; a owl:Class ; rdfs:label "Abnormality of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009285 obo:IAO_0000115 "Curved appearance of the phalanges of the 4th (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:44:14Z" ; oboInOwl:hasDbXref "UMLS:C4024470" ; oboInOwl:hasExactSynonym "Curved ring finger bone" ; oboInOwl:id "HP:0009285" ; a owl:Class ; rdfs:label "Curved phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0004095, obo:HP_0009172, obo:HP_0009770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009286 obo:IAO_0000115 "Curved appearance of the distal phalanx of the 4th (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:46:28Z" ; oboInOwl:hasDbXref "UMLS:C4024469" ; oboInOwl:hasExactSynonym "Curved outermost ring finger bone" ; oboInOwl:id "HP:0009286" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009285, obo:HP_0009838 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009287 obo:IAO_0000115 "Curved appearance of the middle phalanx of the 4th (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:46:28Z" ; oboInOwl:hasDbXref "UMLS:C4024468" ; oboInOwl:hasExactSynonym "Curved middle ring finger bone" ; oboInOwl:id "HP:0009287" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009285, obo:HP_0009846 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009288 dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:46:28Z" ; oboInOwl:hasDbXref "UMLS:C4024467" ; oboInOwl:hasExactSynonym "Curved innermost ring finger bone" ; oboInOwl:id "HP:0009288" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009285, obo:HP_0009854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009289 dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:59:04Z" ; oboInOwl:hasDbXref "UMLS:C4024466" ; oboInOwl:hasExactSynonym "Absent/small outermost ring finger bone", "Absent/underdeveloped outermost ring finger bone" ; oboInOwl:id "HP:0009289" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009290 obo:IAO_0000115 "Hypoplastic/small distal phalanx of the fourth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T03:59:28Z" ; oboInOwl:hasDbXref "UMLS:C4021499" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 4th finger", "Short distal phalanx of the fourth finger", "Short outermost bone of ring finger" ; oboInOwl:id "HP:0009290" ; a owl:Class ; rdfs:label "Short distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009280, obo:HP_0009289, obo:HP_0009882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009291 obo:IAO_0000115 "Absence of the distal phalanx of the ring (4th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:00:27Z" ; oboInOwl:hasDbXref "UMLS:C4024465" ; oboInOwl:hasExactSynonym "Absent outermost bone of ring finger" ; oboInOwl:id "HP:0009291" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009281, obo:HP_0009289, obo:HP_0009881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009292 obo:IAO_0000115 "Increased width of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasDbXref "UMLS:C4024464" ; oboInOwl:hasExactSynonym "Broad outermost bone of ring finger", "Wide outermost bone of ring finger" ; oboInOwl:id "HP:0009292" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009404, obo:HP_0009836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009293 obo:IAO_0000115 "Increased width of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024463" ; oboInOwl:hasExactSynonym "Broad middle bone of the 4th finger" ; oboInOwl:id "HP:0009293" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009404, obo:HP_0009844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009294 obo:IAO_0000115 "Absence of the middle phalanx of the ring (4th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:11:35Z" ; oboInOwl:hasDbXref "UMLS:C4021498" ; oboInOwl:hasExactSynonym "Absent middle bone of 4th finger", "Aplasia of the middle phalanx of the 4th finger" ; oboInOwl:id "HP:0009294" ; a owl:Class ; rdfs:label "Absent middle phalanx of 4th finger" ; rdfs:subClassOf obo:HP_0009281, obo:HP_0009299, obo:HP_0010239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009295 obo:IAO_0000115 "Hypoplastic/small middle phalanx of the 4th finger, also known as the ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:11:35Z" ; oboInOwl:hasAlternativeId "HP:0004205", "HP:0004206" ; oboInOwl:hasDbXref "UMLS:C4021497" ; oboInOwl:hasExactSynonym "Brachymesophalangy IV (finger)", "Hypoplastic/small middle phalanx of ring finger", "Hypoplastic/small middle phalanx of the 4th finger", "Short middle bone of 4th finger", "Short middle phalanx of ring finger" ; oboInOwl:id "HP:0009295" ; a owl:Class ; rdfs:label "Short middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0005819, obo:HP_0009280, obo:HP_0009299 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009296 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 4th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024462" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of the 4th finger" ; oboInOwl:id "HP:0009296" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009405, obo:HP_0009845 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009297 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the middle phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024461" ; oboInOwl:id "HP:0009297" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0004195, obo:HP_0009283, obo:HP_0009847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009298 obo:IAO_0000115 "Absence of the proximal phalanx of the ring (4th) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:22:16Z" ; oboInOwl:hasDbXref "UMLS:C4024460" ; oboInOwl:hasExactSynonym "Absent innermost ring finger bone" ; oboInOwl:id "HP:0009298" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009281, obo:HP_0009300, obo:HP_0010242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009299 dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:27:22Z" ; oboInOwl:hasDbXref "UMLS:C4024459" ; oboInOwl:hasExactSynonym "Absent/small middle ring finger bone", "Absent/underdeveloped middle ring finger bone" ; oboInOwl:id "HP:0009299" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009300 dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:28:54Z" ; oboInOwl:hasAlternativeId "HP:0004203" ; oboInOwl:hasDbXref "UMLS:C4020658" ; oboInOwl:hasExactSynonym "Absent/small innermost ring finger bone", "Absent/underdeveloped innermost ring finger bone" ; oboInOwl:id "HP:0009300" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009301 obo:IAO_0000115 "Hypoplastic/small proximal phalanx of the fourth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:29:38Z" ; oboInOwl:hasDbXref "UMLS:C4021496" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 4th finger", "Short innermost bone of the ring finger", "Short proximal phalanx of the fourth finger" ; oboInOwl:id "HP:0009301" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009280, obo:HP_0009300, obo:HP_0010241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009302 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 4th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasDbXref "UMLS:C4024458" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of ring finger" ; oboInOwl:id "HP:0009302" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009405, obo:HP_0009837 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009303 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the distal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasDbXref "UMLS:C4024457" ; oboInOwl:id "HP:0009303" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0004195, obo:HP_0009282, obo:HP_0009839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009304 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the distal phalanx of the fourth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasDbXref "UMLS:C4024456" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the ring finger" ; oboInOwl:id "HP:0009304" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009406, obo:HP_0009840, obo:HP_0100902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009305 obo:IAO_0000115 "Fusion of the terminal/distal and middle phalanges of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasAlternativeId "HP:0009474", "HP:0009475" ; oboInOwl:hasDbXref "UMLS:C4021495" ; oboInOwl:hasExactSynonym "Fused outermost and middle bones of ring finger", "Symphalangism of the distal and middle phalanges of the 4th finger" ; oboInOwl:id "HP:0009305" ; a owl:Class ; rdfs:label "Distal/middle symphalangism of 4th finger" ; rdfs:subClassOf obo:HP_0001204, obo:HP_0009282, obo:HP_0009308 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009306 obo:IAO_0000115 "Triangular shaped distal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:41:33Z" ; oboInOwl:hasDbXref "UMLS:C4024455" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the ring finger" ; oboInOwl:id "HP:0009306" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009407, obo:HP_0009875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009307 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the middle phalanx of the fourth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024454" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the ring finger" ; oboInOwl:id "HP:0009307" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009406, obo:HP_0009848, obo:HP_0100906 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009308 obo:IAO_0000115 "Fusion of the middle phalanx of the 4th finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024453" ; oboInOwl:hasExactSynonym "Fused middle bone of ring finger" ; oboInOwl:id "HP:0009308" ; a owl:Class ; rdfs:label "Symphalangism of middle phalanx of 4th finger" ; rdfs:subClassOf obo:HP_0004197, obo:HP_0009283, obo:HP_0009849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009309 obo:IAO_0000115 "Triangular shaped middle phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T04:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4024452" ; oboInOwl:hasExactSynonym "Triangular shaped middle bone of the ring finger" ; oboInOwl:id "HP:0009309" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009407, obo:HP_0009850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009310 obo:IAO_0000115 "Increased width of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasAlternativeId "HP:0004201" ; oboInOwl:hasDbXref "UMLS:C4020660" ; oboInOwl:hasExactSynonym "Broad innermost ring finger bone" ; oboInOwl:id "HP:0009310" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009404, obo:HP_0009852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009311 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 4th finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasDbXref "UMLS:C4024451" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost ring finger bone" ; oboInOwl:id "HP:0009311" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009405, obo:HP_0009853 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009312 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal phalanx of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasAlternativeId "HP:0004202" ; oboInOwl:hasDbXref "UMLS:C4024450" ; oboInOwl:id "HP:0009312" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0004195, obo:HP_0009284, obo:HP_0009855 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009313 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the proximal phalanx of the fourth finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasDbXref "UMLS:C4024449" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the ring finger" ; oboInOwl:id "HP:0009313" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009406, obo:HP_0009856, obo:HP_0100910 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009314 obo:IAO_0000115 "Fusion of the proximal phalanx of the 4th finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasDbXref "UMLS:C4024448" ; oboInOwl:hasExactSynonym "Fused innermost bone of ring finger" ; oboInOwl:id "HP:0009314" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0004197, obo:HP_0009284, obo:HP_0009857 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009315 obo:IAO_0000115 "Triangular shaped proximal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-08T05:11:48Z" ; oboInOwl:hasDbXref "UMLS:C4024447" ; oboInOwl:hasExactSynonym "Triangular shaped innermost bone of the 4th finger", "Triangular shaped innermost bone of the ring finger" ; oboInOwl:id "HP:0009315" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009407, obo:HP_0009858 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009316 obo:IAO_0000115 "Abnormality of the phalanges of the 3rd (middle) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:00:24Z" ; oboInOwl:hasAlternativeId "HP:0004155" ; oboInOwl:hasDbXref "UMLS:C4021494" ; oboInOwl:hasExactSynonym "Abnormality of 3rd finger phalanges", "Abnormality of middle finger phalanges", "Abnormality of the middle finger bones", "Abnormality of the phalanges of the 3rd finger" ; oboInOwl:id "HP:0009316" ; a owl:Class ; rdfs:label "Abnormal 3rd finger phalanx morphology" ; rdfs:subClassOf obo:HP_0004150, obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009317 obo:IAO_0000115 "Displacement of the 3rd finger from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:02:27Z" ; oboInOwl:hasAlternativeId "HP:0004152" ; oboInOwl:hasDbXref "UMLS:C4021493" ; oboInOwl:hasExactSynonym "Deviated middle finger" ; oboInOwl:id "HP:0009317" ; a owl:Class ; rdfs:label "Deviation of the 3rd finger" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0004150 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009318 obo:IAO_0000115 "A small/hypoplastic or absent/aplastic 3rd (middle) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:04:08Z" ; oboInOwl:hasDbXref "UMLS:C4024446" ; oboInOwl:hasExactSynonym "Absent/small middle finger", "Absent/underdeveloped middle finger" ; oboInOwl:id "HP:0009318" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 3rd finger" ; rdfs:subClassOf obo:HP_0004150, obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009319 obo:IAO_0000115 "Chronic loss of joint motion in the 3rd finger due to structural changes in non-bony tissue. The term camptodactyly of the 3rd finger is used if the distal and/or proximal interphalangeal joints are affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:05:43Z" ; oboInOwl:hasAlternativeId "HP:0004151" ; oboInOwl:hasDbXref "UMLS:C4021492" ; oboInOwl:hasExactSynonym "Camptodactyly of middle finger" ; oboInOwl:id "HP:0009319" ; a owl:Class ; rdfs:label "Joint contracture of the 3rd finger" ; rdfs:subClassOf obo:HP_0004150, obo:HP_0012785 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009320 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:07:00Z" ; oboInOwl:hasDbXref "UMLS:C4024445" ; oboInOwl:hasExactSynonym "Abnormality of end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009320" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0004150, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009321 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024444" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009321" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009410, obo:HP_0010257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009322 obo:IAO_0000115 "An abnormality of the middle phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024443" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009322" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009411, obo:HP_0010258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009323 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024442" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009323" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009412, obo:HP_0010259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009324 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024441" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009324" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009413, obo:HP_0010260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009325 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024440" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009325" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009414, obo:HP_0010261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009326 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024439" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009326" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009415, obo:HP_0010262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009327 obo:IAO_0000115 "Sclerosis of the epiphysis of the middle phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024438" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009327" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009416, obo:HP_0010263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009328 obo:IAO_0000115 "A secondary ossification center in the middle phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasAlternativeId "HP:0004176" ; oboInOwl:hasDbXref "UMLS:C4021491" ; oboInOwl:hasExactSynonym "Pseudoepiphyses of middle phalanx of middle-finger" ; oboInOwl:id "HP:0009328" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009417, obo:HP_0010264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009329 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024437" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009329" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009418, obo:HP_0010265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009330 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4024436" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009330" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009419, obo:HP_0010266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009331 obo:IAO_0000115 "A triangular appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:15:44Z" ; oboInOwl:hasDbXref "UMLS:C4021490" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the middle phalanx of the 3rd finger", "Triangular end part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009331" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009334, obo:HP_0009420, obo:HP_0010267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009332 dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:16:06Z" ; oboInOwl:hasDbXref "UMLS:C4024435" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009332" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0009357, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009333 dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:16:44Z" ; oboInOwl:hasDbXref "UMLS:C4024434" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the middle finger" ; oboInOwl:id "HP:0009333" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0009358, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009334 dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:16:44Z" ; oboInOwl:hasDbXref "UMLS:C4024433" ; oboInOwl:hasExactSynonym "Abnormality of the middle part of the middle bone of the middle finger" ; oboInOwl:id "HP:0009334" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009320, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009335 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024432" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009335" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009410, obo:HP_0010246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009336 obo:IAO_0000115 "An abnormality of the distal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024431" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009336" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009411, obo:HP_0010247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009337 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024430" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009337" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009412, obo:HP_0010248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009338 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024429" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the 3rd finger" ; oboInOwl:id "HP:0009338" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009413, obo:HP_0010249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009339 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024428" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009339" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009414, obo:HP_0010250 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009340 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024427" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost long bone of the middle finger" ; oboInOwl:id "HP:0009340" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009415, obo:HP_0010251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009341 obo:IAO_0000115 "Sclerosis of the epiphysis of the distal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024426" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost middle finger bone" ; oboInOwl:id "HP:0009341" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009416, obo:HP_0010252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009342 obo:IAO_0000115 "A secondary ossification center in the distal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024425" ; oboInOwl:hasExactSynonym "Pseudoepiphysis of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009342" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009417, obo:HP_0010253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009343 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024424" ; oboInOwl:hasExactSynonym "Small end part of the outermost long bone of the middle finger" ; oboInOwl:id "HP:0009343" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009418, obo:HP_0010254 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009344 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024423" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the outermost long bone of the middle finger" ; oboInOwl:id "HP:0009344" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009419, obo:HP_0010255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009345 obo:IAO_0000115 "A triangular appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4021489" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the distal phalanx of the 3rd finger", "Triangular end part of the outermost long bone of the middle finger" ; oboInOwl:id "HP:0009345" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009332, obo:HP_0009420, obo:HP_0010256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009346 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024422" ; oboInOwl:hasExactSynonym "Absent end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009346" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009410, obo:HP_0010268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009347 obo:IAO_0000115 "An abnormality of the proximal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024421" ; oboInOwl:hasExactSynonym "Bracket shaped end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009347" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009411, obo:HP_0010269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009348 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024420" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the middle finger" ; oboInOwl:id "HP:0009348" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009412, obo:HP_0010270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009349 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasAlternativeId "HP:0004171" ; oboInOwl:hasDbXref "UMLS:C4021488" ; oboInOwl:hasExactSynonym "Enlarged end part of innermost long bone of the middle finger", "Large epiphysis of proximal middle-finger phalanx" ; oboInOwl:id "HP:0009349" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009413, obo:HP_0010271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009350 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024419" ; oboInOwl:hasExactSynonym "Fragmentation of end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009350" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009414, obo:HP_0010272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009351 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024418" ; oboInOwl:hasExactSynonym "Irregular end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009351" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009415, obo:HP_0010273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009352 obo:IAO_0000115 "Sclerosis of the epiphysis of the proximal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024417" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost middle finger bone" ; oboInOwl:id "HP:0009352" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009416, obo:HP_0010274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009353 obo:IAO_0000115 "A secondary ossification center in the proximal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024416" ; oboInOwl:id "HP:0009353" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009417, obo:HP_0010275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009354 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024415" ; oboInOwl:hasExactSynonym "Small end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009354" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009418, obo:HP_0010276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009355 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024414" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009355" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009419, obo:HP_0010277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009356 obo:IAO_0000115 "A triangular appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4021487" ; oboInOwl:hasExactSynonym "Delta-shaped epiphysis of the proximal phalanx of the 3rd finger", "Triangular end part of innermost long bone of the middle finger" ; oboInOwl:id "HP:0009356" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009333, obo:HP_0009420, obo:HP_0010278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009357 dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:40:58Z" ; oboInOwl:hasAlternativeId "HP:0004179" ; oboInOwl:hasDbXref "UMLS:C4021486" ; oboInOwl:hasExactSynonym "Abnormality of terminal phalanx of middle-finger", "Abnormality of the outermost bone of the 3rd finger" ; oboInOwl:id "HP:0009357" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009358 dcterms:creator ; oboInOwl:creation_date "2009-01-12T11:42:37Z" ; oboInOwl:hasAlternativeId "HP:0004167" ; oboInOwl:hasDbXref "UMLS:C4021485" ; oboInOwl:hasExactSynonym "Abnormal innermost bone of middle finger", "Abnormality of proximal middle-finger phalanx" ; oboInOwl:id "HP:0009358" ; a owl:Class ; rdfs:label "Abnormality of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009370 dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:50:19Z" ; oboInOwl:hasDbXref "UMLS:C4024413" ; oboInOwl:id "HP:0009370" ; a owl:Class ; rdfs:label "Type A brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0009371 dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:50:19Z" ; oboInOwl:hasDbXref "MSH:C537088", "SNOMEDCT_US:715720006", "UMLS:C1862151" ; oboInOwl:id "HP:0009371" ; a owl:Class ; rdfs:label "Type A1 brachydactyly" ; rdfs:subClassOf obo:HP_0009370 . obo:HP_0009372 dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:50:19Z" ; oboInOwl:hasDbXref "MSH:C537089", "UMLS:C1832702" ; oboInOwl:hasExactSynonym "Short index fingers and second toes" ; oboInOwl:id "HP:0009372" ; a owl:Class ; rdfs:label "Type A2 brachydactyly" ; rdfs:subClassOf obo:HP_0009370 . obo:HP_0009373 dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:50:19Z" ; oboInOwl:hasDbXref "MSH:C537093", "UMLS:C1862103" ; oboInOwl:id "HP:0009373" ; a owl:Class ; rdfs:label "Type C brachydactyly" ; rdfs:subClassOf obo:HP_0001156 . obo:HP_0009374 obo:IAO_0000115 "Increased width of the phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:55:04Z" ; oboInOwl:hasDbXref "UMLS:C4024412" ; oboInOwl:hasExactSynonym "Broad little finger bones", "Broad pinkie finger bones", "Broad pinky finger bones" ; oboInOwl:id "HP:0009374" ; a owl:Class ; rdfs:label "Broad phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009375 obo:IAO_0000115 "A fifth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T10:58:05Z" ; oboInOwl:hasDbXref "UMLS:C4024411" ; oboInOwl:hasExactSynonym "Bullet-shaped little finger bones", "Bullet-shaped pinkie finger bones", "Bullet-shaped pinky finger bones" ; oboInOwl:id "HP:0009375" ; a owl:Class ; rdfs:label "Bullet-shaped phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009376 obo:IAO_0000115 "Aplasia/Hypoplasia of the phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T11:58:25Z" ; oboInOwl:hasDbXref "UMLS:C4024410" ; oboInOwl:hasExactSynonym "Absent/small little finger bones", "Absent/small pinkie finger bones", "Absent/small pinky finger bones", "Absent/underdeveloped pinky finger bones" ; oboInOwl:id "HP:0009376" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009377 obo:IAO_0000115 "Uneven increase in bone density of one or more of the phalanges of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T12:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4021484" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 5th finger", "Uneven increase in bone density in little finger bone", "Uneven increase in bone density in pinkie finger bone", "Uneven increase in bone density in pinky finger bone" ; oboInOwl:id "HP:0009377" ; a owl:Class ; rdfs:label "Patchy sclerosis of 5th finger phalanx" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009378 obo:IAO_0000115 "Triangular shaped phalanges of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T12:00:35Z" ; oboInOwl:hasDbXref "UMLS:C4024409" ; oboInOwl:hasExactSynonym "Triangular shaped little finger bones", "Triangular shaped pinkie finger bones", "Triangular shaped pinky finger bones" ; oboInOwl:id "HP:0009378" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009379 obo:IAO_0000115 "Rhomboid or triangular shaped 5th (little) finger distal phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:01:44Z" ; oboInOwl:hasDbXref "UMLS:C4024408" ; oboInOwl:hasExactSynonym "Rhomboid or triangular shaped little finger bone", "Rhomboid or triangular shaped pinkie finger bone", "Rhomboid or triangular shaped pinky finger bone" ; oboInOwl:id "HP:0009379" ; a owl:Class ; rdfs:label "Rhomboid or triangular shaped 5th finger distal phalanx" ; rdfs:subClassOf obo:HP_0009245 . obo:HP_0009380 obo:IAO_0000115 "Aplasia of one or more fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:05:32Z" ; oboInOwl:hasAlternativeId "HP:0004093" ; oboInOwl:hasDbXref "SNOMEDCT_US:71358006", "UMLS:C0728895" ; oboInOwl:hasExactSynonym "Absent fingers" ; oboInOwl:id "HP:0009380" ; a owl:Class ; rdfs:label "Aplasia of the fingers" ; rdfs:subClassOf obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009381 obo:IAO_0000115 "Abnormally short finger associated with developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:07:38Z" ; oboInOwl:hasAlternativeId "HP:0004098", "HP:0006015" ; oboInOwl:hasDbXref "SNOMEDCT_US:249765007", "UMLS:C0239594", "UMLS:C1844548" ; oboInOwl:hasExactSynonym "Hypoplastic digits", "Hypoplastic fingers", "Hypoplastic/small fingers", "Short finger", "Stubby finger", "Stubby fingers" ; oboInOwl:id "HP:0009381" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short finger" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0006265, obo:HP_0011927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009382 obo:IAO_0000115 "Absence of one or more epiphyses of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024407" ; oboInOwl:hasExactSynonym "Absent end part of little finger bone", "Absent end part of pinkie finger bone", "Absent end part of pinky finger bone" ; oboInOwl:id "HP:0009382" ; a owl:Class ; rdfs:label "Absent epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009383 obo:IAO_0000115 "An abnormality of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024406" ; oboInOwl:hasExactSynonym "Bracket shaped end part of little finger bone", "Bracket shaped end part of pinkie finger bone", "Bracket shaped end part of pinky finger bone" ; oboInOwl:id "HP:0009383" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009384 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the 5th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024405" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the little finger bones", "Cone-shaped end part of the pinkie finger bones", "Cone-shaped end part of the pinky finger bones" ; oboInOwl:id "HP:0009384" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009385 obo:IAO_0000115 "Abnormally large size of the epiphyses of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024404" ; oboInOwl:hasExactSynonym "Enlarged end part of the little finger bones", "Enlarged end part of the pinkie finger bones", "Enlarged end part of the pinky finger bones" ; oboInOwl:id "HP:0009385" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009386 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024403" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the little finger bones", "Fragmentation of the end part of the pinkie finger bones", "Fragmentation of the end part of the pinky finger bones" ; oboInOwl:id "HP:0009386" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009387 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024402" ; oboInOwl:hasExactSynonym "Irregular end part of the little finger bones", "Irregular end part of the pinkie finger bones", "Irregular end part of the pinky finger bones" ; oboInOwl:id "HP:0009387" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009388 obo:IAO_0000115 "Sclerosis of the epiphyses of the 5th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024401" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the little finger", "Increased bone density of end part of the pinkie finger", "Increased bone density of end part of the pinky finger" ; oboInOwl:id "HP:0009388" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010234, obo:HP_0100921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009389 obo:IAO_0000115 "A secondary ossification center in the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024400" ; oboInOwl:id "HP:0009389" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009390 obo:IAO_0000115 "Abnormally small size of the epiphyses of the 5th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024399" ; oboInOwl:hasExactSynonym "Small end part of little finger bone", "Small end part of pinkie finger bone", "Small end part of pinky finger bone" ; oboInOwl:id "HP:0009390" ; a owl:Class ; rdfs:label "Small epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009391 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4024398" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of little finger bone", "Speckled calcifications in end part of pinkie finger bone", "Speckled calcifications in end part of pinky finger bone" ; oboInOwl:id "HP:0009391" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009392 obo:IAO_0000115 "A triangular appearance of the epiphyses of the 5th finger of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:19:03Z" ; oboInOwl:hasDbXref "UMLS:C4021483" ; oboInOwl:hasExactSynonym "Delta-shaped epiphyses of the 5th finger", "Triangular end part of the little finger", "Triangular end part of the pinkie finger", "Triangular end part of the pinky finger" ; oboInOwl:id "HP:0009392" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 5th finger" ; rdfs:subClassOf obo:HP_0009152, obo:HP_0010238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009393 obo:IAO_0000115 "Absence of one or more epiphyses of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024397" ; oboInOwl:hasExactSynonym "Absent end part of the ring finger bone" ; oboInOwl:id "HP:0009393" ; a owl:Class ; rdfs:label "Absent epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009394 obo:IAO_0000115 "An abnormality of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasAlternativeId "HP:0004192" ; oboInOwl:hasDbXref "UMLS:C4024396" ; oboInOwl:hasExactSynonym "Bracket shaped end part of ring finger bones" ; oboInOwl:id "HP:0009394" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009395 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the 4th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024395" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the ring finger bones" ; oboInOwl:id "HP:0009395" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009396 obo:IAO_0000115 "Abnormally large size of the epiphyses of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024394" ; oboInOwl:hasExactSynonym "Enlarged end part of the ring finger bones" ; oboInOwl:id "HP:0009396" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009397 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024393" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the ring finger bones" ; oboInOwl:id "HP:0009397" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009398 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024392" ; oboInOwl:hasExactSynonym "Irregular end part of the ring finger bones" ; oboInOwl:id "HP:0009398" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009399 obo:IAO_0000115 "Sclerosis of the epiphyses of the 4th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024391" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the ring finger bone" ; oboInOwl:id "HP:0009399" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010234, obo:HP_0100920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009400 obo:IAO_0000115 "A secondary ossification center in the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024390" ; oboInOwl:id "HP:0009400" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009401 obo:IAO_0000115 "Abnormally small size of the epiphyses of the 4th finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024389" ; oboInOwl:hasExactSynonym "Small end part of ring finger bone" ; oboInOwl:id "HP:0009401" ; a owl:Class ; rdfs:label "Small epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009402 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4024388" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of ring finger bone" ; oboInOwl:id "HP:0009402" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009403 obo:IAO_0000115 "A triangular appearance of the epiphyses of the 4th finger of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T01:59:12Z" ; oboInOwl:hasDbXref "UMLS:C4021482" ; oboInOwl:hasExactSynonym "Delta-shaped epiphyses of the 4th finger", "Triangular end part of ring finger bone" ; oboInOwl:id "HP:0009403" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 4th finger" ; rdfs:subClassOf obo:HP_0009174, obo:HP_0010238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009404 obo:IAO_0000115 "Increased width of the phalanges of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T02:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4024387" ; oboInOwl:hasExactSynonym "Broad bones of ring finger" ; oboInOwl:id "HP:0009404" ; a owl:Class ; rdfs:label "Broad phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009405 obo:IAO_0000115 "A fourth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T02:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4024386" ; oboInOwl:hasExactSynonym "Bullet-shaped of bone of ring finger" ; oboInOwl:id "HP:0009405" ; a owl:Class ; rdfs:label "Bullet-shaped phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009406 obo:IAO_0000115 "Uneven increase in bone density of one or more of the phalanges of the fourth (ring) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T02:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4021481" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 4th finger", "Uneven increase in bone density in ring finger bone" ; oboInOwl:id "HP:0009406" ; a owl:Class ; rdfs:label "Patchy sclerosis of 4th finger phalanx" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009407 obo:IAO_0000115 "Triangular shaped phalanges of the 4th finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-13T02:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4024385" ; oboInOwl:hasExactSynonym "Triangular shaped bone of ring finger" ; oboInOwl:id "HP:0009407" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009408 dcterms:creator ; oboInOwl:creation_date "2009-01-13T02:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4024384" ; oboInOwl:hasExactSynonym "Absent/small ring finger bones", "Absent/underdeveloped ring finger bones" ; oboInOwl:id "HP:0009408" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009410 obo:IAO_0000115 "Absence of the epiphyses of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024383" ; oboInOwl:hasExactSynonym "Absent end part of middle finger bone" ; oboInOwl:id "HP:0009410" ; a owl:Class ; rdfs:label "Absent epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009411 obo:IAO_0000115 "An abnormality of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024382" ; oboInOwl:hasExactSynonym "Bracket shaped end part of middle finger bone" ; oboInOwl:id "HP:0009411" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009412 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024381" ; oboInOwl:hasExactSynonym "Cone-shaped end part of middle finger bone" ; oboInOwl:id "HP:0009412" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009413 obo:IAO_0000115 "Abnormally large size of the epiphyses of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024380" ; oboInOwl:hasExactSynonym "Enlarged end part of middle finger bone" ; oboInOwl:id "HP:0009413" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009414 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024379" ; oboInOwl:hasExactSynonym "Fragmentation of end part of middle finger bone" ; oboInOwl:id "HP:0009414" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009415 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024378" ; oboInOwl:hasExactSynonym "Irregular end part of middle finger bone" ; oboInOwl:id "HP:0009415" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009416 obo:IAO_0000115 "Sclerosis of the epiphyses of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024377" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle finger bone" ; oboInOwl:id "HP:0009416" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010234, obo:HP_0100919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009417 obo:IAO_0000115 "A secondary ossification center in the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasAlternativeId "HP:0004163" ; oboInOwl:hasDbXref "UMLS:C4021480" ; oboInOwl:hasExactSynonym "Pseudoepiphyses of middle finger phalanges" ; oboInOwl:id "HP:0009417" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009418 obo:IAO_0000115 "Abnormally small size of the epiphyses of the 3rd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024376" ; oboInOwl:hasExactSynonym "Small end part of middle finger bone" ; oboInOwl:id "HP:0009418" ; a owl:Class ; rdfs:label "Small epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009419 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4024375" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of middle finger bone" ; oboInOwl:id "HP:0009419" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009420 obo:IAO_0000115 "A triangular appearance of the epiphyses of the 3rd finger of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T02:01:59Z" ; oboInOwl:hasDbXref "UMLS:C4021479" ; oboInOwl:hasExactSynonym "Delta-shaped epiphyses of the 3rd finger", "Triangular end part of middle finger bone" ; oboInOwl:id "HP:0009420" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 3rd finger" ; rdfs:subClassOf obo:HP_0009320, obo:HP_0010238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009421 dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024374" ; oboInOwl:hasExactSynonym "Absent/small outermost middle finger bone", "Absent/underdeveloped outermost middle finger bone" ; oboInOwl:id "HP:0009421" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009422 obo:IAO_0000115 "Increased width of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024373" ; oboInOwl:hasExactSynonym "Broad outermost bone of middle finger" ; oboInOwl:id "HP:0009422" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009440, obo:HP_0009836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009423 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 3rd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024372" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the middle finger" ; oboInOwl:id "HP:0009423" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009441, obo:HP_0009837 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009424 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasAlternativeId "HP:0004181" ; oboInOwl:hasDbXref "UMLS:C4021478" ; oboInOwl:hasExactSynonym "Lytic defect of terminal phalanx of middle finger" ; oboInOwl:id "HP:0009424" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009443, obo:HP_0009839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009425 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the distal phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024371" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the 3rd finger" ; oboInOwl:id "HP:0009425" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009444, obo:HP_0009840, obo:HP_0100901 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009426 obo:IAO_0000115 "Fusion of the terminal/distal and middle phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasAlternativeId "HP:0009479", "HP:0009480" ; oboInOwl:hasDbXref "UMLS:C4021477" ; oboInOwl:hasExactSynonym "Fused outermost and middle bones of middle finger", "Symphalangism of the distal and middle phalanges of the 3rd finger" ; oboInOwl:id "HP:0009426" ; a owl:Class ; rdfs:label "Distal/middle symphalangism of 3rd finger" ; rdfs:subClassOf obo:HP_0001204, obo:HP_0009357, obo:HP_0009435 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009427 obo:IAO_0000115 "Triangular shaped distal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024370" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the middle finger" ; oboInOwl:id "HP:0009427" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009446, obo:HP_0009875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009428 obo:IAO_0000115 "Curved appearance of the distal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:16:46Z" ; oboInOwl:hasDbXref "UMLS:C4024369" ; oboInOwl:hasExactSynonym "Curved outermost bone of the 3rd finger" ; oboInOwl:id "HP:0009428" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009442, obo:HP_0009838 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009429 obo:IAO_0000115 "Absence of the distal phalanx of the middle (3rd) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:18:42Z" ; oboInOwl:hasDbXref "UMLS:C4024368" ; oboInOwl:hasExactSynonym "Absent of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009429" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009421, obo:HP_0009460, obo:HP_0009881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009430 obo:IAO_0000115 "Increased width of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasAlternativeId "HP:0004178" ; oboInOwl:hasDbXref "UMLS:C4021476" ; oboInOwl:hasExactSynonym "Broad middle bone of middle finger", "Wide/broad middle phalanx of middle-finger" ; oboInOwl:id "HP:0009430" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009440, obo:HP_0009844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009431 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 3rd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024367" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of middle finger" ; oboInOwl:id "HP:0009431" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009441, obo:HP_0009845 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009432 obo:IAO_0000115 "Curved appearance of the middle phalanx of the 3rd (middle) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024366" ; oboInOwl:hasExactSynonym "Curved middle bone of the middle finger" ; oboInOwl:id "HP:0009432" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009442, obo:HP_0009846 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009433 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the middle phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024365" ; oboInOwl:id "HP:0009433" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009443, obo:HP_0009847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009434 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the middle phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024364" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the middle finger" ; oboInOwl:id "HP:0009434" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009444, obo:HP_0009848, obo:HP_0100905 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009435 obo:IAO_0000115 "Fusion of the middle phalanx of the 3rd finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024363" ; oboInOwl:hasExactSynonym "Fused middle bone of middle finger" ; oboInOwl:id "HP:0009435" ; a owl:Class ; rdfs:label "Symphalangism of middle phalanx of 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009445, obo:HP_0009849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009436 obo:IAO_0000115 "Triangular shaped middle phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024362" ; oboInOwl:hasExactSynonym "Triangular shaped middle bone of the middle finger" ; oboInOwl:id "HP:0009436" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009446, obo:HP_0009850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009437 dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:41:31Z" ; oboInOwl:hasDbXref "UMLS:C4024361" ; oboInOwl:hasExactSynonym "Absent/small middle bone of the middle finger", "Absent/underdeveloped middle bone of the middle finger" ; oboInOwl:id "HP:0009437" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009438 obo:IAO_0000115 "Absence of the middle phalanx of the middle (3rd) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:45:02Z" ; oboInOwl:hasAlternativeId "HP:0004173" ; oboInOwl:hasDbXref "UMLS:C4021475" ; oboInOwl:hasExactSynonym "Absent middle bone of middle finger", "Absent middle phalanx of middle finger", "Aplasia of the middle phalanx of the 3rd finger" ; oboInOwl:id "HP:0009438" ; a owl:Class ; rdfs:label "Absent middle phalanx of 3rd finger" ; rdfs:subClassOf obo:HP_0009437, obo:HP_0009460, obo:HP_0010239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009439 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the middle phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T03:45:02Z" ; oboInOwl:hasAlternativeId "HP:0004177", "HP:0006212" ; oboInOwl:hasDbXref "UMLS:C4021474" ; oboInOwl:hasExactSynonym "Brachymesophalangy III (finger)", "Hypoplastic/small middle phalanx of the 3rd finger", "Short middle bone of middle finger" ; oboInOwl:id "HP:0009439" ; a owl:Class ; rdfs:label "Short middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0005819, obo:HP_0009437, obo:HP_0009461 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009440 obo:IAO_0000115 "Increased width of the phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasAlternativeId "HP:0004166" ; oboInOwl:hasDbXref "UMLS:C4021473" ; oboInOwl:hasExactSynonym "Wide bones of middle finger", "Wide/broad middle finger phalanges" ; oboInOwl:id "HP:0009440" ; a owl:Class ; rdfs:label "Broad phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009441 obo:IAO_0000115 "A third finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasDbXref "UMLS:C4024360" ; oboInOwl:hasExactSynonym "Bullet-shaped bones of middle finger" ; oboInOwl:id "HP:0009441" ; a owl:Class ; rdfs:label "Bullet-shaped phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009442 obo:IAO_0000115 "Curved appearance of the phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasDbXref "UMLS:C4024359" ; oboInOwl:hasExactSynonym "Curved bones of middle finger" ; oboInOwl:id "HP:0009442" ; a owl:Class ; rdfs:label "Curved phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0004095, obo:HP_0009316, obo:HP_0009770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009443 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasAlternativeId "HP:0004159" ; oboInOwl:hasDbXref "UMLS:C4021472" ; oboInOwl:hasExactSynonym "Lytic defects of middle finger phalanges" ; oboInOwl:id "HP:0009443" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009444 obo:IAO_0000115 "Uneven (irregular) increase in bone density of one or more of the phalanges of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasAlternativeId "HP:0004160" ; oboInOwl:hasDbXref "UMLS:C4021471" ; oboInOwl:hasExactSynonym "Patchy sclerosis of middle finger phalanges", "Patchy sclerosis of the phalanges of the 3rd finger", "Uneven increase in bone density in middle finger bone" ; oboInOwl:id "HP:0009444" ; a owl:Class ; rdfs:label "Patchy sclerosis of 3rd finger phalanx" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009445 obo:IAO_0000115 "Fusion of two or more bones of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasDbXref "UMLS:C4024358" ; oboInOwl:hasExactSynonym "Fused middle finger" ; oboInOwl:id "HP:0009445" ; a owl:Class ; rdfs:label "Symphalangism of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009700, obo:HP_0009773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009446 obo:IAO_0000115 "Triangular shaped phalanges of the 3rd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasDbXref "UMLS:C4024357" ; oboInOwl:hasExactSynonym "Triangular shaped bone of the middle finger" ; oboInOwl:id "HP:0009446" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009447 dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:09:01Z" ; oboInOwl:hasAlternativeId "HP:0004156", "HP:0004158", "HP:0004164", "HP:0004165", "HP:0009449" ; oboInOwl:hasDbXref "UMLS:C4024356" ; oboInOwl:hasExactSynonym "Absent/small middle finger bone", "Absent/underdeveloped middle finger bone", "Hypoplastic middle finger phalanges", "Short middle finger phalanges", "Small middle finger phalanges" ; oboInOwl:id "HP:0009447" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009448 oboInOwl:consider "HP:0009447" ; oboInOwl:id "HP:0009448" ; a owl:Class ; rdfs:label "obsolete Aplasia of the phalanges of the 3rd finger" ; owl:deprecated true . obo:HP_0009449 obo:IAO_0100001 "HP:0009447" ; oboInOwl:id "HP:0009449" ; a owl:Class ; rdfs:label "obsolete Hypoplastic/small phalanges of the 3rd finger" ; owl:deprecated true . obo:HP_0009450 obo:IAO_0000115 "Increased width of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024355" ; oboInOwl:hasExactSynonym "Broad innermost bone of middle finger" ; oboInOwl:id "HP:0009450" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009440, obo:HP_0009852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009451 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 3rd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024354" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost bone of the middle finger" ; oboInOwl:id "HP:0009451" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009441, obo:HP_0009853 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009452 obo:IAO_0000115 "Curved appearance of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024353" ; oboInOwl:hasExactSynonym "Curved innermost bone of middle finger" ; oboInOwl:id "HP:0009452" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009442, obo:HP_0009854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009453 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024352" ; oboInOwl:id "HP:0009453" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009443, obo:HP_0009855 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009454 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the proximal phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024351" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the middle finger" ; oboInOwl:id "HP:0009454" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009444, obo:HP_0009856, obo:HP_0100909 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009455 obo:IAO_0000115 "Fusion of the proximal phalanx of the 3rd finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024350" ; oboInOwl:hasExactSynonym "Fused innermost bone of middle finger" ; oboInOwl:id "HP:0009455" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009445, obo:HP_0009857 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009456 obo:IAO_0000115 "Triangular shaped proximal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:33:41Z" ; oboInOwl:hasDbXref "UMLS:C4024349" ; oboInOwl:hasExactSynonym "Triangular shaped innermost bone of middle finger" ; oboInOwl:id "HP:0009456" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009446, obo:HP_0009858 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009457 dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:34:45Z" ; oboInOwl:hasDbXref "UMLS:C4024348" ; oboInOwl:hasExactSynonym "Absent/small innermost bone of middle finger", "Absent/underdeveloped innermost bone of middle finger" ; oboInOwl:id "HP:0009457" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009458 obo:IAO_0000115 "Absence of the proximal phalanx of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:35:28Z" ; oboInOwl:hasDbXref "UMLS:C4024347" ; oboInOwl:hasExactSynonym "Absent innermost bone of middle finger" ; oboInOwl:id "HP:0009458" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009457, obo:HP_0009460, obo:HP_0010242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009459 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the proximal phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:35:28Z" ; oboInOwl:hasAlternativeId "HP:0004169", "HP:0004170" ; oboInOwl:hasDbXref "UMLS:C4021470" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 3rd finger", "Short innermost bone of middle finger", "Short proximal middle-finger phalanx", "Short proximal phalanx of the third finger", "Small proximal middle-finger phalanx" ; oboInOwl:id "HP:0009459" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009457, obo:HP_0009461, obo:HP_0010241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009460 obo:IAO_0000115 "Absent 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:56:33Z" ; oboInOwl:hasDbXref "UMLS:C4024346" ; oboInOwl:hasExactSynonym "Absent middle finger" ; oboInOwl:id "HP:0009460" ; a owl:Class ; rdfs:label "Aplasia of the 3rd finger" ; rdfs:subClassOf obo:HP_0009318, obo:HP_0009380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009461 obo:IAO_0000115 "Hypoplastic/small 3rd (middle) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-14T04:57:43Z" ; oboInOwl:hasAlternativeId "HP:0004154" ; oboInOwl:hasDbXref "UMLS:C4021469" ; oboInOwl:hasExactSynonym "Hypoplastic/small 3rd finger", "Short 3rd finger", "Short middle finger" ; oboInOwl:id "HP:0009461" ; a owl:Class ; rdfs:label "Short 3rd finger" ; rdfs:subClassOf obo:HP_0009318, obo:HP_0009381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009462 obo:IAO_0000115 "Displacement of the 3rd finger towards the radial side (i.e., towards the thumb)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:35:10Z" ; oboInOwl:hasDbXref "UMLS:C4024345" ; oboInOwl:hasExactSynonym "Inward turned middle finger" ; oboInOwl:id "HP:0009462" ; a owl:Class ; rdfs:label "Radial deviation of the 3rd finger" ; rdfs:subClassOf obo:HP_0009317, obo:HP_0009466 . obo:HP_0009463 obo:IAO_0000115 "Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:35:47Z" ; oboInOwl:hasAlternativeId "HP:0005865", "HP:0006022" ; oboInOwl:hasDbXref "UMLS:C3554614" ; oboInOwl:hasExactSynonym "Ulnar deviation of middle fingers" ; oboInOwl:id "HP:0009463" ; a owl:Class ; rdfs:label "Ulnar deviation of the 3rd finger" ; rdfs:subClassOf obo:HP_0009317, obo:HP_0009465 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009464 obo:IAO_0000115 "Displacement of the 2nd (index) finger towards the ulnar side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:37:48Z" ; oboInOwl:hasAlternativeId "HP:0004102", "HP:0005811" ; oboInOwl:hasDbXref "UMLS:C1844891" ; oboInOwl:hasExactSynonym "Medially deviated index finger", "Second finger ulnar deviation", "Ulnar angulation of the index finger", "Ulnar deviation of index fingers" ; oboInOwl:id "HP:0009464" ; a owl:Class ; rdfs:label "Ulnar deviation of the 2nd finger" ; rdfs:subClassOf obo:HP_0009465, obo:HP_0009468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009465 obo:IAO_0000115 "Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:39:43Z" ; oboInOwl:hasAlternativeId "HP:0001200", "HP:0004096" ; oboInOwl:hasDbXref "SNOMEDCT_US:276662009", "SNOMEDCT_US:367510009", "UMLS:C0231679" ; oboInOwl:hasExactSynonym "Finger bends toward pinky", "Ulnar Drift" ; oboInOwl:id "HP:0009465" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ulnar deviation of finger" ; rdfs:subClassOf obo:HP_0001193, obo:HP_0004097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009466 obo:IAO_0000115 "Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:40:27Z" ; oboInOwl:hasAlternativeId "HP:0001157", "HP:0001213", "HP:0001503" ; oboInOwl:hasDbXref "UMLS:C1836189" ; oboInOwl:hasExactSynonym "Radially deviated fingers", "Radially deviated phalanges" ; oboInOwl:id "HP:0009466" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Radial deviation of finger" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0009485 . obo:HP_0009467 obo:IAO_0000115 "Displacement of the 2nd finger towards the radial side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:40:58Z" ; oboInOwl:hasAlternativeId "HP:0004103", "HP:0006053" ; oboInOwl:hasDbXref "UMLS:C1844709" ; oboInOwl:hasExactSynonym "Radially deviated index finger" ; oboInOwl:id "HP:0009467" ; a owl:Class ; rdfs:label "Radial deviation of the 2nd finger" ; rdfs:subClassOf obo:HP_0009466, obo:HP_0009468 . obo:HP_0009468 obo:IAO_0000115 "Displacement of the 2nd finger from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:42:36Z" ; oboInOwl:hasAlternativeId "HP:0004101" ; oboInOwl:hasDbXref "UMLS:C4021468" ; oboInOwl:hasExactSynonym "Deviated index finger", "Displaced index finger" ; oboInOwl:id "HP:0009468" ; a owl:Class ; rdfs:label "Deviation of the 2nd finger" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0004100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009469 obo:IAO_0000115 "Chronic loss of joint motion of the distal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:50:20Z" ; oboInOwl:hasDbXref "UMLS:C4024344" ; oboInOwl:hasExactSynonym "Contracture of the outermost hinge joint of the 3rd finger" ; oboInOwl:id "HP:0009469" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 3rd finger" ; rdfs:subClassOf obo:HP_0009319, obo:HP_0009697 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014508 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009470 obo:IAO_0000115 "Chronic loss of joint motion of the metacarpophalangeal joint of the 3rd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:50:20Z" ; oboInOwl:hasDbXref "UMLS:C4024343" ; oboInOwl:id "HP:0009470" ; a owl:Class ; rdfs:label "Contracture of the metacarpophalangeal joint of the 3rd finger" ; rdfs:subClassOf obo:HP_0009319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007741 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009471 obo:IAO_0000115 "Chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:50:20Z" ; oboInOwl:hasDbXref "UMLS:C4021467" ; oboInOwl:hasExactSynonym "Camptodactyly of the 3rd finger", "Camptodactyly of the third finger" ; oboInOwl:id "HP:0009471" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 3rd finger" ; rdfs:subClassOf obo:HP_0009319, obo:HP_0100490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009473 obo:IAO_0000115 "Contractures of one ore more joints of the hands meaning chronic loss of joint motion due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T09:59:59Z" ; oboInOwl:hasAlternativeId "HP:0001160", "HP:0001237", "HP:0004094", "HP:0005814", "HP:0006096", "HP:0006173", "HP:0006215", "HP:0006238", "HP:0006255", "HP:0009409", "HP:0009472", "HP:0010563" ; oboInOwl:hasDbXref "MEDDRA:10010821", "SNOMEDCT_US:86414002", "UMLS:C0158113" ; oboInOwl:hasExactSynonym "Contractures involving the hands", "Contractures of the hands" ; oboInOwl:id "HP:0009473" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Joint contracture of the hand" ; rdfs:subClassOf obo:HP_0001155, obo:HP_0009810, obo:HP_0100360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009477 obo:IAO_0000115 "Fusion of the proximal and middle phalanges of the 4th finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:24:03Z" ; oboInOwl:hasAlternativeId "HP:0009476" ; oboInOwl:hasDbXref "UMLS:C4024342" ; oboInOwl:hasExactSynonym "Fused innermost and middle bone of fourth finger" ; oboInOwl:id "HP:0009477" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 4th finger" ; rdfs:subClassOf obo:HP_0006152, obo:HP_0009308, obo:HP_0009314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009478 obo:IAO_0000115 "Fusion of the proximal phalanx of the 4th finger with the 4th metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:24:03Z" ; oboInOwl:hasDbXref "UMLS:C4024341" ; oboInOwl:hasExactSynonym "Fused innermost bone of ring finger with 4th long bone of hand" ; oboInOwl:id "HP:0009478" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 4th finger with the 4th metacarpal" ; rdfs:subClassOf obo:HP_0005880, obo:HP_0009314, obo:HP_0009707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009482 obo:IAO_0000115 "Fusion of the proximal and middle phalanges of the 3rd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:29:08Z" ; oboInOwl:hasAlternativeId "HP:0009481" ; oboInOwl:hasDbXref "UMLS:C4024340" ; oboInOwl:hasExactSynonym "Fused of innermost and middle bones of middle finger" ; oboInOwl:id "HP:0009482" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 3rd finger" ; rdfs:subClassOf obo:HP_0006152, obo:HP_0009435, obo:HP_0009455 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009483 obo:IAO_0000115 "Fusion of the proximal phalanx of the 3rd finger with the 3rd metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:29:08Z" ; oboInOwl:hasDbXref "UMLS:C4024339" ; oboInOwl:hasExactSynonym "Fused innermost bones of middle finger with middle long bone of hand" ; oboInOwl:id "HP:0009483" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 3rd finger with the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0005880, obo:HP_0009455, obo:HP_0009706 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009484 obo:IAO_0000115 "Displacement of the hand or of fingers of the hand from their normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:45:01Z" ; oboInOwl:hasDbXref "UMLS:C4024338" ; oboInOwl:hasExactSynonym "Displaced hand or fingers of the hand" ; oboInOwl:id "HP:0009484" ; a owl:Class ; rdfs:label "Deviation of the hand or of fingers of the hand" ; rdfs:subClassOf obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009485 dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:49:51Z" ; oboInOwl:hasDbXref "UMLS:C4024337" ; oboInOwl:id "HP:0009485" ; a owl:Class ; rdfs:label "Radial deviation of the hand or of fingers of the hand" ; rdfs:subClassOf obo:HP_0009484 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009466 obo:HP_0009486 ) ] ] . obo:HP_0009486 obo:IAO_0000115 "An abnormal position of the hand in which the wrist is bent toward the radius (i.e., toward the thumb)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:51:21Z" ; oboInOwl:hasAlternativeId "HP:0001203" ; oboInOwl:hasDbXref "SNOMEDCT_US:299035006", "UMLS:C0575803" ; oboInOwl:hasExactSynonym "Radial deviation of hands" ; oboInOwl:id "HP:0009486" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Radial deviation of the hand" ; rdfs:subClassOf obo:HP_0009485 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009487 obo:IAO_0000115 "Divergence of the longitudinal axis of the hand at the wrist in a posterior (ulnar) direction (i.e., towards the little finger)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-15T10:51:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249757009", "UMLS:C0241521" ; oboInOwl:hasExactSynonym "Ulnar deviation of hands", "Ulnar deviation of the hands" ; oboInOwl:id "HP:0009487" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ulnar deviation of the hand" ; rdfs:subClassOf obo:HP_0001193 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009488 obo:IAO_0000115 "Absence of the epiphyses of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024336" ; oboInOwl:hasExactSynonym "Absent end part of index finger" ; oboInOwl:id "HP:0009488" ; a owl:Class ; rdfs:label "Absent epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002234 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009489 obo:IAO_0000115 "An abnormality of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasAlternativeId "HP:0004109" ; oboInOwl:hasDbXref "UMLS:C4021466" ; oboInOwl:hasExactSynonym "Bracket shaped end part of index finger", "Bracket-epiphyses of index finger" ; oboInOwl:id "HP:0009489" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009490 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024335" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the index finger" ; oboInOwl:id "HP:0009490" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009491 obo:IAO_0000115 "Abnormally large size of the epiphyses of the 2nd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024334" ; oboInOwl:hasExactSynonym "Enlarged end part of the index finger" ; oboInOwl:id "HP:0009491" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009492 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024333" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the index finger" ; oboInOwl:id "HP:0009492" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009493 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024332" ; oboInOwl:hasExactSynonym "Irregular end part of the index finger" ; oboInOwl:id "HP:0009493" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009494 obo:IAO_0000115 "Sclerosis of the epiphyses of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024331" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the index finger bone" ; oboInOwl:id "HP:0009494" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010234, obo:HP_0100918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009495 obo:IAO_0000115 "A secondary ossification center in the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasAlternativeId "HP:0004107", "HP:0006142" ; oboInOwl:hasDbXref "UMLS:C4021465" ; oboInOwl:hasExactSynonym "Accessory index finger epiphysis" ; oboInOwl:id "HP:0009495" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009496 obo:IAO_0000115 "Abnormally small size of the epiphyses of the 2nd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024330" ; oboInOwl:hasExactSynonym "Small end part of the index finger" ; oboInOwl:id "HP:0009496" ; a owl:Class ; rdfs:label "Small epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009497 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024329" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the index finger" ; oboInOwl:id "HP:0009497" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009498 obo:IAO_0000115 "A triangular appearance of the epiphyses of the 2nd finger of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4024328" ; oboInOwl:hasExactSynonym "Triangular end part of the index finger" ; oboInOwl:id "HP:0009498" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0010238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009499 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:08:35Z" ; oboInOwl:hasAlternativeId "HP:0004146" ; oboInOwl:hasDbXref "UMLS:C4021464" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the index finger", "Epiphyseal abnormality of terminal index finger phalanx" ; oboInOwl:id "HP:0009499" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0009542, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009500 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:08:35Z" ; oboInOwl:hasAlternativeId "HP:0004135" ; oboInOwl:hasDbXref "UMLS:C4021463" ; oboInOwl:hasExactSynonym "Abnormality of end part of the middle bone of the index finger", "Epiphyseal abnormality of middle phalanx of the 2nd finger" ; oboInOwl:id "HP:0009500" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0009543, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009501 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:08:35Z" ; oboInOwl:hasAlternativeId "HP:0004127" ; oboInOwl:hasDbXref "UMLS:C4021462" ; oboInOwl:hasExactSynonym "Epiphyseal abnormality of the proximal phalanx of the 2nd finger" ; oboInOwl:id "HP:0009501" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0006263, obo:HP_0009544, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009502 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasAlternativeId "HP:0004147" ; oboInOwl:hasDbXref "UMLS:C4021461" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the index finger", "Absent ossification/absent epiphysis of terminal index finger phalanx" ; oboInOwl:id "HP:0009502" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009488, obo:HP_0009499, obo:HP_0010246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009503 obo:IAO_0000115 "An abnormality of the distal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024327" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009503" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009489, obo:HP_0009499, obo:HP_0010247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009504 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024326" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009504" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009490, obo:HP_0009499, obo:HP_0010248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009505 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024325" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009505" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009491, obo:HP_0009499, obo:HP_0010249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009506 obo:IAO_0000115 "Fragmented appearance of the epiphysis of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024324" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009506" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009492, obo:HP_0009499, obo:HP_0010250 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009507 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024323" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009507" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009493, obo:HP_0009499, obo:HP_0010251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009508 obo:IAO_0000115 "Sclerosis of the epiphysis of the distal phalanx of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasAlternativeId "HP:0004148" ; oboInOwl:hasDbXref "UMLS:C4021460" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the index finger", "Ivory epiphysis of terminal index finger phalanx" ; oboInOwl:id "HP:0009508" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009494, obo:HP_0009499, obo:HP_0010252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009509 obo:IAO_0000115 "A secondary ossification center in the distal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024322" ; oboInOwl:id "HP:0009509" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009495, obo:HP_0009499, obo:HP_0010253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009510 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024321" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009510" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009496, obo:HP_0009499, obo:HP_0010254 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009511 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024320" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009511" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009497, obo:HP_0009499, obo:HP_0010255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009512 obo:IAO_0000115 "A triangular appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4024319" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the index finger" ; oboInOwl:id "HP:0009512" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009498, obo:HP_0009499, obo:HP_0010256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009513 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasAlternativeId "HP:0004136" ; oboInOwl:hasDbXref "UMLS:C4021459" ; oboInOwl:hasExactSynonym "Absent epiphyses of middle phalanx of index finger", "Missing end part of the middle long bone of the index finger" ; oboInOwl:id "HP:0009513" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009488, obo:HP_0009500, obo:HP_0010257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009514 obo:IAO_0000115 "An abnormality of the middle phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024318" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle long bone of the index finger" ; oboInOwl:id "HP:0009514" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009489, obo:HP_0009500, obo:HP_0010258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009515 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasAlternativeId "HP:0004137" ; oboInOwl:hasDbXref "UMLS:C4021458" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle long bone of the index finger", "Cone-shaped epiphyses of middle phalanx of index finger" ; oboInOwl:id "HP:0009515" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009490, obo:HP_0009500, obo:HP_0010259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009516 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024317" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the index finger" ; oboInOwl:id "HP:0009516" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009491, obo:HP_0009500, obo:HP_0010260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009517 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024316" ; oboInOwl:hasExactSynonym "Fragmentation of end part of the middle long bone of the index finger" ; oboInOwl:id "HP:0009517" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009492, obo:HP_0009500, obo:HP_0010261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009518 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024315" ; oboInOwl:hasExactSynonym "Irregular end part of the middle long bone of the index finger" ; oboInOwl:id "HP:0009518" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009493, obo:HP_0009500, obo:HP_0010262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009519 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024314" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the index finger" ; oboInOwl:id "HP:0009519" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009494, obo:HP_0009500, obo:HP_0010263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009520 obo:IAO_0000115 "A secondary ossification center in the middle phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024313" ; oboInOwl:id "HP:0009520" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009495, obo:HP_0009500, obo:HP_0010264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009521 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024312" ; oboInOwl:hasExactSynonym "Small end part of the innermost long bone of index finger" ; oboInOwl:id "HP:0009521" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009496, obo:HP_0009500, obo:HP_0010265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009522 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024311" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the middle bone of the index finger" ; oboInOwl:id "HP:0009522" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009497, obo:HP_0009500, obo:HP_0010266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009523 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:17Z" ; oboInOwl:hasDbXref "UMLS:C4024310" ; oboInOwl:hasExactSynonym "Triangular end part of the middle bone of the index finger" ; oboInOwl:id "HP:0009523" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009498, obo:HP_0009500, obo:HP_0010267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009524 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024309" ; oboInOwl:hasExactSynonym "Absent end part of innermost long bone of index finger" ; oboInOwl:id "HP:0009524" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009488, obo:HP_0009501, obo:HP_0010268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009525 obo:IAO_0000115 "An abnormality of the proximal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasAlternativeId "HP:0004120" ; oboInOwl:hasDbXref "UMLS:C4021457" ; oboInOwl:hasExactSynonym "Bracket epiphyses of proximal index finger phalanx", "Bracket shaped end part of innermost long bone of index finger" ; oboInOwl:id "HP:0009525" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009489, obo:HP_0009501, obo:HP_0010269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009526 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasAlternativeId "HP:0004128" ; oboInOwl:hasDbXref "UMLS:C4021456" ; oboInOwl:hasExactSynonym "Cone-shaped end part of innermost long bone of index finger", "Cone-shaped epiphysis of proximal index finger phalanx" ; oboInOwl:id "HP:0009526" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009490, obo:HP_0009501, obo:HP_0010270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009527 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasAlternativeId "HP:0004129" ; oboInOwl:hasDbXref "UMLS:C4021455" ; oboInOwl:hasExactSynonym "Enlarged end part of innermost long bone of index finger", "Large epiphysis of proximal index finger phalanx" ; oboInOwl:id "HP:0009527" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009491, obo:HP_0009501, obo:HP_0010271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009528 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024308" ; oboInOwl:hasExactSynonym "Fragmentation of end part of innermost long bone of index finger" ; oboInOwl:id "HP:0009528" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009492, obo:HP_0009501, obo:HP_0010272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009529 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024307" ; oboInOwl:hasExactSynonym "Irregular end part of innermost long bone of index finger" ; oboInOwl:id "HP:0009529" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009493, obo:HP_0009501, obo:HP_0010273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009530 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024306" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the index finger" ; oboInOwl:id "HP:0009530" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009494, obo:HP_0009501, obo:HP_0010274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009531 obo:IAO_0000115 "A secondary ossification center in the proximal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024305" ; oboInOwl:id "HP:0009531" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009495, obo:HP_0009501, obo:HP_0010275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009532 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024304" ; oboInOwl:hasExactSynonym "Small end part of proximal long bond of index finger" ; oboInOwl:id "HP:0009532" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009496, obo:HP_0009501, obo:HP_0010276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009533 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4024303" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the innermost long bone of index finger" ; oboInOwl:id "HP:0009533" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009497, obo:HP_0009501, obo:HP_0010277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009534 dcterms:creator ; oboInOwl:creation_date "2009-01-16T01:12:34Z" ; oboInOwl:hasAlternativeId "HP:0004130" ; oboInOwl:hasDbXref "UMLS:C4021454" ; oboInOwl:hasExactSynonym "Triangular end part of innermost long bone of index finger", "Triangular epiphysis of proximal index finger phalanx" ; oboInOwl:id "HP:0009534" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009498, obo:HP_0009501, obo:HP_0010278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009535 obo:IAO_0000115 "Absent 2nd (index) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-19T04:18:22Z" ; oboInOwl:hasAlternativeId "HP:0004106" ; oboInOwl:hasDbXref "UMLS:C4021453" ; oboInOwl:hasExactSynonym "Absent index finger", "Absent index finger phalanges", "Aplasia of the index finger" ; oboInOwl:id "HP:0009535" ; a owl:Class ; rdfs:label "Aplasia of the 2nd finger" ; rdfs:subClassOf obo:HP_0006264, obo:HP_0009380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009536 obo:IAO_0000115 "Hypoplasia of the second finger, also known as the index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-19T04:18:22Z" ; oboInOwl:hasAlternativeId "HP:0004104", "HP:0004113", "HP:0004115", "HP:0005796" ; oboInOwl:hasDbXref "UMLS:C1862142" ; oboInOwl:hasExactSynonym "Hypoplastic index finger phalanges", "Hypoplastic/small index finger", "Short index finger", "Short index finger phalanges", "Short index fingers" ; oboInOwl:id "HP:0009536" ; a owl:Class ; rdfs:label "Short 2nd finger" ; rdfs:subClassOf obo:HP_0006264, obo:HP_0009381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009537 obo:IAO_0000115 "Chronic loss of joint motion in the 2nd finger due to structural changes in non-bony tissue. The term camptodactyly of the 2nd finger is used if the distal and/or proximal interphalangeal joints are affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:10:27Z" ; oboInOwl:hasDbXref "UMLS:C4021452" ; oboInOwl:hasExactSynonym "Joint contractures of the 2nd finger" ; oboInOwl:id "HP:0009537" ; a owl:Class ; rdfs:label "Flexion contracture of the 2nd finger" ; rdfs:subClassOf obo:HP_0004100, obo:HP_0012785 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009538 obo:IAO_0000115 "Chronic loss of joint motion of the distal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:11:49Z" ; oboInOwl:hasDbXref "UMLS:C4024302" ; oboInOwl:id "HP:0009538" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 2nd finger" ; rdfs:subClassOf obo:HP_0009537, obo:HP_0009697 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014668 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009539 obo:IAO_0000115 "Chronic loss of joint motion of the metacarpophalangeal joint of the 2nd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:11:49Z" ; oboInOwl:hasDbXref "UMLS:C4024301" ; oboInOwl:id "HP:0009539" ; a owl:Class ; rdfs:label "Contracture of the metacarpophalangeal joint of the 2nd finger" ; rdfs:subClassOf obo:HP_0009537 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003695 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009540 obo:IAO_0000115 "Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:11:49Z" ; oboInOwl:hasDbXref "UMLS:C4021451" ; oboInOwl:hasExactSynonym "Camptodactyly of 2nd finger", "Camptodactyly of index finger", "Camptodactyly of second finger" ; oboInOwl:id "HP:0009540" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 2nd finger" ; rdfs:subClassOf obo:HP_0009537, obo:HP_0100490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009541 obo:IAO_0000115 "Abnormality of the phalanges of the 2nd (index) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:15:07Z" ; oboInOwl:hasAlternativeId "HP:0004105" ; oboInOwl:hasDbXref "UMLS:C4021450" ; oboInOwl:hasExactSynonym "Abnormal index finger bones", "Abnormality of 2nd finger phalanges" ; oboInOwl:id "HP:0009541" ; a owl:Class ; rdfs:label "Abnormality of the phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0004100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005918 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009542 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:17:15Z" ; oboInOwl:hasAlternativeId "HP:0004111", "HP:0004140" ; oboInOwl:hasDbXref "UMLS:C4021449" ; oboInOwl:hasExactSynonym "Abnormality of terminal index finger phalanx", "Abnormality of the outermost bone of the 2nd finger" ; oboInOwl:id "HP:0009542" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009543 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:17:15Z" ; oboInOwl:hasAlternativeId "HP:0004131" ; oboInOwl:hasDbXref "UMLS:C4021448" ; oboInOwl:hasExactSynonym "Abnormal middle index finger bone", "Abnormality of middle 2nd finger phalanx" ; oboInOwl:id "HP:0009543" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009544 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:17:15Z" ; oboInOwl:hasAlternativeId "HP:0004119" ; oboInOwl:hasDbXref "UMLS:C4021447" ; oboInOwl:hasExactSynonym "Abnormal innermost index finger bone", "Abnormality of the proximal 2nd finger phalanx" ; oboInOwl:id "HP:0009544" ; a owl:Class ; rdfs:label "Abnormality of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009545 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:19:34Z" ; oboInOwl:hasAlternativeId "HP:0004116" ; oboInOwl:hasDbXref "UMLS:C4021446" ; oboInOwl:hasExactSynonym "Fused index finger bones", "Symphalangism of index finger phalanges" ; oboInOwl:id "HP:0009545" ; a owl:Class ; rdfs:label "Symphalangism of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0009700, obo:HP_0009773 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009546 obo:IAO_0000115 "Triangular shaped phalanges of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:19:34Z" ; oboInOwl:hasAlternativeId "HP:0004117" ; oboInOwl:hasDbXref "UMLS:C4021445" ; oboInOwl:hasExactSynonym "Triangular bones of index finger", "Triangular index finger phalanges" ; oboInOwl:id "HP:0009546" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009547 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:19:34Z" ; oboInOwl:hasAlternativeId "HP:0004118" ; oboInOwl:hasDbXref "UMLS:C4021444" ; oboInOwl:hasExactSynonym "Wide index finger bones", "Wide/broad index finger phalanges" ; oboInOwl:id "HP:0009547" ; a owl:Class ; rdfs:label "Broad phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0009768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009548 obo:IAO_0000115 "A second finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:20:26Z" ; oboInOwl:hasDbXref "UMLS:C4024300" ; oboInOwl:hasExactSynonym "Bullet-shaped index finger bones" ; oboInOwl:id "HP:0009548" ; a owl:Class ; rdfs:label "Bullet-shaped phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009549 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:20:26Z" ; oboInOwl:hasDbXref "UMLS:C4024299" ; oboInOwl:hasExactSynonym "Curved index finger bones" ; oboInOwl:id "HP:0009549" ; a owl:Class ; rdfs:label "Curved phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0004095, obo:HP_0009541, obo:HP_0009770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009550 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:20:26Z" ; oboInOwl:hasAlternativeId "HP:0004114" ; oboInOwl:hasDbXref "UMLS:C4021443" ; oboInOwl:hasExactSynonym "Lytic defect in index finger phalanges" ; oboInOwl:id "HP:0009550" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0009771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009551 obo:IAO_0000115 "Uneven (irregular) increase in bone density of one or more of the phalanges of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:20:26Z" ; oboInOwl:hasDbXref "UMLS:C4021442" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 2nd finger", "Uneven increase in bone density in index finger bone" ; oboInOwl:id "HP:0009551" ; a owl:Class ; rdfs:label "Patchy sclerosis of 2nd finger phalanx" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009552 dcterms:creator ; oboInOwl:creation_date "2009-01-21T10:20:26Z" ; oboInOwl:hasDbXref "UMLS:C4024298" ; oboInOwl:hasExactSynonym "Absent/small index finger bone", "Absent/underdeveloped index finger bone" ; oboInOwl:id "HP:0009552" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009553 obo:IAO_0000115 "The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T05:19:14Z" ; oboInOwl:hasDbXref "UMLS:C4024297" ; oboInOwl:hasExactSynonym "Abnormality of the hairline" ; oboInOwl:id "HP:0009553" ; a owl:Class ; rdfs:label "Abnormality of the hairline" ; rdfs:subClassOf obo:HP_0011361, obo:HP_0100037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004104 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009554 obo:IAO_0000115 "An tongue-like extension of hair towards the cheeks, in which hair growth extends in front of the ear to the lateral cheekbones." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T05:21:54Z" ; oboInOwl:hasDbXref "UMLS:C4024296" ; oboInOwl:hasExactSynonym "Hair displacement, preauricular, towards lateral cheekbone", "Hair growing down to cheek", "Projection of scalp hair onto lateral cheek" ; oboInOwl:id "HP:0009554" ; a owl:Class ; rdfs:label "Preauricular hair displacement" ; rdfs:subClassOf obo:HP_0009553 . obo:HP_0009555 obo:IAO_0000115 "Underdevelopment of the pharynx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-21T05:24:16Z" ; oboInOwl:hasBroadSynonym "Small pharynx" ; oboInOwl:hasDbXref "UMLS:C4024295", "UMLS:C4280396", "UMLS:C4280397", "UMLS:C4280398", "UMLS:C4280399", "UMLS:C4280400" ; oboInOwl:hasExactSynonym "Decreased size of pharynx", "Underdevelopment of pharynx" ; oboInOwl:hasNarrowSynonym "Decreased diameter of pharynx", "Decreased length of pharynx", "Decreased volume of pharynx", "Decreased width of pharynx" ; oboInOwl:hasRelatedSynonym "Hypotrophic pharynx" ; oboInOwl:id "HP:0009555" ; a owl:Class ; rdfs:label "Hypoplasia of the pharynx" ; rdfs:subClassOf obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009556 obo:IAO_0000115 "Absence of the tibia." ; dcterms:creator ; oboInOwl:creation_date "2009-01-27T06:09:44Z" ; oboInOwl:hasDbXref "UMLS:C3276744" ; oboInOwl:hasExactSynonym "Absent shankbone", "Absent shinbone", "Aplasia of the tibia" ; oboInOwl:id "HP:0009556" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent tibia" ; rdfs:subClassOf obo:HP_0005772, obo:HP_0009817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009557 dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024294" ; oboInOwl:hasExactSynonym "Absent/small outermost index finger bone", "Absent/underdeveloped outermost index finger bone" ; oboInOwl:id "HP:0009557" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009552 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009558 obo:IAO_0000115 "Increased width of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024293" ; oboInOwl:hasExactSynonym "Wide outermost bone of the index finger" ; oboInOwl:id "HP:0009558" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009547, obo:HP_0009836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009559 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 2nd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024292" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the index finger" ; oboInOwl:id "HP:0009559" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009548, obo:HP_0009837 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009560 obo:IAO_0000115 "Curved appearance of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024291" ; oboInOwl:hasExactSynonym "Curved outermost bone of the index finger" ; oboInOwl:id "HP:0009560" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009549, obo:HP_0009838 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009561 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the distal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasAlternativeId "HP:0004108", "HP:0004142" ; oboInOwl:hasDbXref "UMLS:C4021441" ; oboInOwl:hasExactSynonym "Acro-osteolysis of index finger", "Acro-osteolysis of terminal index finger phalanx", "Osteolytic defects of the outermost bone of the 2nd finger" ; oboInOwl:id "HP:0009561" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009550, obo:HP_0009839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009771 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009562 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the distal phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024290" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the 2nd finger" ; oboInOwl:id "HP:0009562" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009551, obo:HP_0009840, obo:HP_0100900 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009563 obo:IAO_0000115 "Fusion of the terminal/distal and middle phalanges of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasAlternativeId "HP:0009567", "HP:0009578" ; oboInOwl:hasDbXref "UMLS:C4021440" ; oboInOwl:hasExactSynonym "Fused outermost and middle index finger bones", "Symphalangism of the distal and middle phalanges of the 2nd finger" ; oboInOwl:id "HP:0009563" ; a owl:Class ; rdfs:label "Distal/middle symphalangism of 2nd finger" ; rdfs:subClassOf obo:HP_0001204, obo:HP_0009542, obo:HP_0009574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009564 obo:IAO_0000115 "Triangular shaped distal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4024289" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the 2nd finger" ; oboInOwl:id "HP:0009564" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009546, obo:HP_0009875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009565 dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:20:22Z" ; oboInOwl:hasAlternativeId "HP:0004141", "HP:0005748" ; oboInOwl:hasDbXref "UMLS:C4021439" ; oboInOwl:hasExactSynonym "Absent outermost index finger bone", "Absent terminal index finger phalanx" ; oboInOwl:id "HP:0009565" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009535, obo:HP_0009557, obo:HP_0009881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009566 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the distal phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T04:20:22Z" ; oboInOwl:hasAlternativeId "HP:0004145" ; oboInOwl:hasDbXref "UMLS:C4021438" ; oboInOwl:hasExactSynonym "Hypoplastic terminal index finger phalanx", "Hypoplastic/small distal phalanx of the 2nd finger", "Short distal phalanx of the second finger", "Short outermost bone of the index finger", "Short terminal index finger phalanx" ; oboInOwl:id "HP:0009566" ; a owl:Class ; rdfs:label "Short distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009536, obo:HP_0009557, obo:HP_0009882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009568 dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasAlternativeId "HP:0006221" ; oboInOwl:hasDbXref "UMLS:C1862144" ; oboInOwl:hasExactSynonym "Absent/hypoplastic middle phalanx of 2nd finger", "Absent/small middle index finger bone", "Absent/underdeveloped middle index finger bone", "Hypoplastic/aplastic middle phalanx of index finger" ; oboInOwl:id "HP:0009568" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009552 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009569 obo:IAO_0000115 "Increased width of the middle phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024288" ; oboInOwl:hasExactSynonym "Broad middle bone of the index finger" ; oboInOwl:id "HP:0009569" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009547, obo:HP_0009844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009570 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 2nd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024287" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of index finger" ; oboInOwl:id "HP:0009570" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009548, obo:HP_0009845 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009571 obo:IAO_0000115 "Curved appearance of the middle phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024286" ; oboInOwl:hasExactSynonym "Curved middle bone of the index finger" ; oboInOwl:id "HP:0009571" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009549, obo:HP_0009846 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009572 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the middle phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasAlternativeId "HP:0004134" ; oboInOwl:hasDbXref "UMLS:C4021437" ; oboInOwl:hasExactSynonym "Lytic defects of middle index finger phalanx" ; oboInOwl:id "HP:0009572" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009550, obo:HP_0009847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009573 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the middle phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024285" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the index finger" ; oboInOwl:id "HP:0009573" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009551, obo:HP_0009848, obo:HP_0100904 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009574 obo:IAO_0000115 "Fusion of the middle phalanx of the 2nd finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024284" ; oboInOwl:hasExactSynonym "Fused middle bone of index finger" ; oboInOwl:id "HP:0009574" ; a owl:Class ; rdfs:label "Symphalangism of middle phalanx of 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009545, obo:HP_0009849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009575 obo:IAO_0000115 "Triangular shaped middle phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:10:24Z" ; oboInOwl:hasDbXref "UMLS:C4024283" ; oboInOwl:hasExactSynonym "Triangular shaped middle bone of index finger" ; oboInOwl:id "HP:0009575" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009546, obo:HP_0009850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009576 obo:IAO_0000115 "Absence of the middle phalanx of the index (2nd) finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:15:55Z" ; oboInOwl:hasAlternativeId "HP:0005760" ; oboInOwl:hasDbXref "UMLS:C4021436" ; oboInOwl:hasExactSynonym "Absent middle bone of index finger", "Absent middle phalanx of index finger", "Aplasia of the middle phalanx of the 2nd finger" ; oboInOwl:id "HP:0009576" ; a owl:Class ; rdfs:label "Absent middle phalanx of 2nd finger" ; rdfs:subClassOf obo:HP_0009535, obo:HP_0009568, obo:HP_0010239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009577 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the middle phalanx of the second finger, also known as the index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:15:55Z" ; oboInOwl:hasAlternativeId "HP:0004133" ; oboInOwl:hasDbXref "UMLS:C4021435" ; oboInOwl:hasExactSynonym "Brachymesophalangy II (finger)", "Hypoplastic middle index finger phalanx", "Hypoplastic/small middle phalanx of the 2nd finger", "Short middle bone of index finger" ; oboInOwl:id "HP:0009577" ; a owl:Class ; rdfs:label "Short middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0005819, obo:HP_0009536, obo:HP_0009568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009579 obo:IAO_0000115 "Fusion of the proximal and middle phalanges of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:23:12Z" ; oboInOwl:hasDbXref "UMLS:C4024282" ; oboInOwl:hasExactSynonym "Fused innermost and middle index finger bones" ; oboInOwl:id "HP:0009579" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of the 2nd finger" ; rdfs:subClassOf obo:HP_0006152, obo:HP_0009574, obo:HP_0009586 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009580 dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasDbXref "UMLS:C4024281" ; oboInOwl:hasExactSynonym "Absent/small innermost index finger bone", "Absent/underdeveloped innermost index finger bone" ; oboInOwl:id "HP:0009580" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009552 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009581 obo:IAO_0000115 "Increased width of the proximal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasAlternativeId "HP:0004126" ; oboInOwl:hasDbXref "UMLS:C4021434" ; oboInOwl:hasExactSynonym "Wide innermost bone of index finger", "Wide/broad proximal index finger phalanx" ; oboInOwl:id "HP:0009581" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009547, obo:HP_0009852 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009582 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 2nd finger is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasDbXref "UMLS:C4024280" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost bone of index finger" ; oboInOwl:id "HP:0009582" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009548, obo:HP_0009853 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009583 obo:IAO_0000115 "Curved appearance of the proximal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasDbXref "UMLS:C4024279" ; oboInOwl:hasExactSynonym "Curved innermost bone of index finger" ; oboInOwl:id "HP:0009583" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009549, obo:HP_0009854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009584 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasAlternativeId "HP:0004123" ; oboInOwl:hasDbXref "UMLS:C4021433" ; oboInOwl:hasExactSynonym "Lytic defects of proximal index finger phalanx" ; oboInOwl:id "HP:0009584" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009550, obo:HP_0009855 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009585 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the proximal phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasDbXref "UMLS:C4024278" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in innermost index finger bone" ; oboInOwl:id "HP:0009585" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009551, obo:HP_0009856, obo:HP_0100908 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009586 obo:IAO_0000115 "Fusion of the proximal phalanx of the 2nd finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasDbXref "UMLS:C4024277" ; oboInOwl:hasExactSynonym "Fused innermost bone of index finger" ; oboInOwl:id "HP:0009586" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009545, obo:HP_0009857 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009587 obo:IAO_0000115 "Triangular shaped proximal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T05:26:39Z" ; oboInOwl:hasAlternativeId "HP:0004125" ; oboInOwl:hasDbXref "UMLS:C4021432" ; oboInOwl:hasExactSynonym "Triangular proximal index finger phalanx", "Triangular shaped innermost bone of index finger" ; oboInOwl:id "HP:0009587" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009546, obo:HP_0009858 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009588 obo:IAO_0000115 "A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma) is a benign, usually slow-growing tumor that develops from the VIIIth cranial nerve supplying the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:37:32Z" ; oboInOwl:hasDbXref "MSH:D009464", "NCIT:C3269", "SNOMEDCT_US:126949007", "SNOMEDCT_US:985004", "UMLS:C0027859" ; oboInOwl:hasExactSynonym "Acoustic Neuroma", "Vestibular Schwann cell tumor", "Vestibular Schwann cell tumour", "Vestibular neurilemmoma", "Vestibular neurinoma", "Vestibular neurolemmoma" ; oboInOwl:id "HP:0009588" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vestibular schwannoma" ; rdfs:subClassOf obo:HP_0009591, obo:HP_0040096, obo:HP_0100008 . obo:HP_0009589 obo:IAO_0000115 "A bilateral vestibular schwannoma (acoustic neurinoma)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:39:14Z" ; oboInOwl:hasDbXref "MSH:D016518", "UMLS:C1136042" ; oboInOwl:hasExactSynonym "Bilateral acoustic neuromas" ; oboInOwl:id "HP:0009589" ; a owl:Class ; rdfs:label "Bilateral vestibular schwannoma" ; rdfs:subClassOf obo:HP_0009588 . obo:HP_0009590 obo:IAO_0000115 "A unilateral vestibular schwannoma (acoustic neurinoma)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:40:23Z" ; oboInOwl:hasDbXref "UMLS:C1863653" ; oboInOwl:id "HP:0009590" ; a owl:Class ; rdfs:label "Unilateral vestibular schwannoma" ; rdfs:subClassOf obo:HP_0009588 . obo:HP_0009591 obo:IAO_0000115 "Any structural anomaly of the vestibulocochlear nerve. The vestibulocochlear nerve consists of the vestibular and cochlear nerves, also known as cranial nerve eight (CN VIII). Each nerve has distinct nuclei within the brainstem. The vestibular nerve is primarily responsible for maintaining body balance and eye movements, while the cochlear nerve is responsible for hearing." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:42:57Z" ; oboInOwl:hasDbXref "UMLS:C4021431" ; oboInOwl:hasExactSynonym "Abnormality of the VIIIth cranial nerve", "Abnormality of the eighth cranial nerve" ; oboInOwl:id "HP:0009591" ; a owl:Class ; rdfs:label "Abnormality of the vestibulocochlear nerve" ; rdfs:subClassOf obo:HP_0001291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009592 obo:IAO_0000115 "Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:51:01Z" ; oboInOwl:hasDbXref "MSH:D001254", "SNOMEDCT_US:38713004", "UMLS:C0004114" ; oboInOwl:id "HP:0009592" ; a owl:Class ; rdfs:label "Astrocytoma" ; rdfs:subClassOf obo:HP_0009733, obo:HP_0100707 . obo:HP_0009593 obo:IAO_0000115 "The presence of a peripheral schwannoma." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:55:58Z" ; oboInOwl:hasDbXref "UMLS:C4024276" ; oboInOwl:id "HP:0009593" ; a owl:Class ; rdfs:comment "A Peripheral schwannoma (also known as neurilemoma) is a benign, usually encapsulated neoplasm derived from Schwann cells." ; rdfs:label "Peripheral schwannoma" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0100008 . obo:HP_0009594 obo:IAO_0000115 "A hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T10:58:47Z" ; oboInOwl:hasDbXref "UMLS:C1863411" ; oboInOwl:id "HP:0009594" ; a owl:Class ; rdfs:label "Retinal hamartoma" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0010568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:MPATH_74 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009595 obo:IAO_0000115 "Neurofibromas present in a smaller number than usually seen in neurofibromatosis type 1." ; dcterms:creator ; oboInOwl:creation_date "2009-01-28T11:12:19Z" ; oboInOwl:hasDbXref "UMLS:C3810474" ; oboInOwl:id "HP:0009595" ; a owl:Class ; rdfs:label "Occasional neurofibromas" ; rdfs:subClassOf obo:HP_0001067 . obo:HP_0009596 obo:IAO_0000115 "Absence of the proximal phalanx of the 2nd finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T10:19:36Z" ; oboInOwl:hasDbXref "UMLS:C4024275" ; oboInOwl:hasExactSynonym "Absent innermost bone of index finger" ; oboInOwl:id "HP:0009596" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009535, obo:HP_0009580, obo:HP_0010242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009597 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the proximal phalanx of the second finger." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T10:19:36Z" ; oboInOwl:hasAlternativeId "HP:0004124" ; oboInOwl:hasDbXref "UMLS:C4021430" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 2nd finger", "Short proximal index finger phalanx", "Short proximal phalanx of the second finger" ; oboInOwl:id "HP:0009597" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009536, obo:HP_0009580, obo:HP_0010241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009598 obo:IAO_0000115 "Fusion of the proximal phalanx of the 2nd finger with the 2nd metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T10:21:45Z" ; oboInOwl:hasDbXref "UMLS:C4024274" ; oboInOwl:hasExactSynonym "Fused innermost bone of index finger with 2nd long bone of hand" ; oboInOwl:id "HP:0009598" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 2nd finger with the 2nd metacarpal" ; rdfs:subClassOf obo:HP_0005880, obo:HP_0009586, obo:HP_0009705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009599 obo:IAO_0000115 "Abnormality of one or all of the epiphyses of the proximal, and distal phalanges of the thumb and/or the 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T11:46:15Z" ; oboInOwl:hasAlternativeId "HP:0004074" ; oboInOwl:hasDbXref "UMLS:C4021429" ; oboInOwl:hasExactSynonym "Abnormality of end part of thumb long bone", "Abnormality of the epiphyses of the thumb", "Abnormality of thumb epiphyses" ; oboInOwl:id "HP:0009599" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits)." ; rdfs:label "Abnormality of thumb epiphysis" ; rdfs:subClassOf obo:HP_0001172, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005930 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009600 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the thumb joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin. The term camptodactyly is used if the distal and/or proximal interphalangeal joints are affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T01:06:31Z" ; oboInOwl:hasAlternativeId "HP:0004061", "HP:0006043" ; oboInOwl:hasDbXref "SNOMEDCT_US:239736003", "UMLS:C0409346" ; oboInOwl:hasExactSynonym "Contracture of thumb", "Flexion deformities of thumbs", "Joint contractures of the thumb", "Thumb joint contracture" ; oboInOwl:id "HP:0009600" ; a owl:Class ; rdfs:label "Thumb contracture" ; rdfs:subClassOf obo:HP_0001172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009601 obo:IAO_0000115 "Hypoplastic/small or absent thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T01:08:24Z" ; oboInOwl:hasAlternativeId "HP:0002950", "HP:0006225" ; oboInOwl:hasDbXref "MSH:C536903", "UMLS:C3179508" ; oboInOwl:hasExactSynonym "Absent or hypoplastic thumbs", "Absent/hypoplastic thumb", "Absent/hypoplastic thumbs", "Absent/small thumb", "Absent/underdeveloped thumb", "Aplasia/hypoplasia of thumbs", "Aplastic/hypoplastic thumbs", "Hypoplastic to aplastic thumbs", "Hypoplastic/absent thumb", "Thumb aplasia/hypoplasia" ; oboInOwl:id "HP:0009601" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the thumb" ; rdfs:subClassOf obo:HP_0001172, obo:HP_0006265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009602 obo:IAO_0000115 "A structural anomaly of one or more phalanges of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T01:10:39Z" ; oboInOwl:hasAlternativeId "HP:0004063", "HP:0004064" ; oboInOwl:hasDbXref "UMLS:C4021428" ; oboInOwl:hasExactSynonym "Abnormality of the thumb bones", "Abnormality of thumb phalanges" ; oboInOwl:id "HP:0009602" ; a owl:Class ; rdfs:label "Abnormality of thumb phalanx" ; rdfs:subClassOf obo:HP_0001172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005918 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009603 obo:IAO_0000115 "Displacement of the thumb from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T01:49:57Z" ; oboInOwl:hasAlternativeId "HP:0004062" ; oboInOwl:hasDbXref "UMLS:C3552414" ; oboInOwl:hasExactSynonym "Abnormal thumb placement", "Deviated thumb", "Displacement of the thumb" ; oboInOwl:id "HP:0009603" ; a owl:Class ; rdfs:label "Deviation of the thumb" ; rdfs:subClassOf obo:HP_0001172, obo:HP_0004097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009606 obo:IAO_0000115 "Complete duplication of the distal phalanx of the thumb. On x-ray two separate bones appear side to side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:28:16Z" ; oboInOwl:hasAlternativeId "HP:0004084", "HP:0005784" ; oboInOwl:hasDbXref "UMLS:C4021427" ; oboInOwl:hasExactSynonym "Complete duplication of outermost bone of the thumb" ; oboInOwl:id "HP:0009606" ; a owl:Class ; rdfs:label "Complete duplication of distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009612, obo:HP_0009943, obo:HP_0010001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009608 obo:IAO_0000115 "Complete duplication of the proximal phalanx of the thumb. On x-ray two separate bones appear side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:32:28Z" ; oboInOwl:hasAlternativeId "HP:0004078" ; oboInOwl:hasDbXref "UMLS:C4024273" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost bone of the thumb" ; oboInOwl:id "HP:0009608" ; a owl:Class ; rdfs:label "Complete duplication of proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009613, obo:HP_0009943, obo:HP_0010002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009609 obo:IAO_0000115 "Partail or complete duplication of the first metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:33:31Z" ; oboInOwl:hasDbXref "UMLS:C4021426" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the 1st long bone of hand", "Partial/complete duplication of the 1st metacarpal" ; oboInOwl:id "HP:0009609" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin. This term applies if the first metacarpal is completely or partially duplicated. Depending on the severity, the appearance on x-ray can vary from a notched metacarpal (the duplicated bone is almost completely fused with the metacarpal), a partially fused appearance of the two bones (in most cases the fused bone resembles a Y-shape), or two separate metacarpal bones appearing side to side." ; rdfs:label "Duplication of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0010006, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009615 obo:HP_0009616 ) ] ] . obo:HP_0009611 obo:IAO_0000115 "Partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:48:49Z" ; oboInOwl:hasAlternativeId "HP:0004086", "HP:0005703", "HP:0005827", "HP:0005848", "HP:0006090" ; oboInOwl:hasDbXref "UMLS:C1860162" ; oboInOwl:hasExactSynonym "Bifid distal phalanx of thumb", "Bifid terminal phalanges of thumbs", "Bifid thumb distal phalanx", "Incipient distal thumb phalanx duplication", "Notched outermost bone of the thumb", "Notched outermost bone of thumb", "Notched terminal thumb phalanx" ; oboInOwl:id "HP:0009611" ; a owl:Class ; rdfs:comment "Note that with bifid distal phalanx, the terminal phalanx of the thumb is clefted but is still one bone. With duplication of the terminal phalanx of the thumb, the distal phalanx is split into two bones that are located side by side. With triphalangeal thumb, the thumb has three phalanxes located one after the other." ; rdfs:label "Bifid distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009612, obo:HP_0009944, obo:HP_0010004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009612 obo:IAO_0000115 "Complete or partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:51:43Z" ; oboInOwl:hasDbXref "UMLS:C4021425" ; oboInOwl:hasExactSynonym "Double thumb distal phalanges", "Duplicated terminal phalanx of thumb", "Duplication of distal thumb phalanx", "Duplication of terminal thumb phalanx", "Duplication of the outermost bone of the thumb", "Partial/complete duplication of the distal phalanx of the thumb" ; oboInOwl:id "HP:0009612" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009883, obo:HP_0009942 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009606 obo:HP_0009611 ) ] ] . obo:HP_0009613 obo:IAO_0000115 "Complete or partial duplication of the proximal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T03:59:56Z" ; oboInOwl:hasDbXref "UMLS:C4021424" ; oboInOwl:hasExactSynonym "Notched innermost bone of thumb", "Partial/complete duplication of the proximal phalanx of the thumb" ; oboInOwl:id "HP:0009613" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009942, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009608 obo:HP_0009614 ) ] ] . obo:HP_0009614 obo:IAO_0000115 "This term applies if the proximal phalanx of the thumb is partially duplicated. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:01:27Z" ; oboInOwl:hasDbXref "UMLS:C4024272" ; oboInOwl:hasExactSynonym "Notched thumb bone" ; oboInOwl:id "HP:0009614" ; a owl:Class ; rdfs:label "Bifid proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009613, obo:HP_0009944, obo:HP_0010005 . obo:HP_0009615 obo:IAO_0000115 "Complete duplication of the first metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:06:17Z" ; oboInOwl:hasDbXref "UMLS:C4024271" ; oboInOwl:hasExactSynonym "Complete duplication of the first long bone of hand" ; oboInOwl:id "HP:0009615" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin, equivalent to the proximal phalanges of the other digits. This term applies if the first metacarpal is completely duplicated. On x-ray two separate metacarpal bones appear side to side. This term applies if the first metacarpal is completely duplicated." ; rdfs:label "Complete duplication of the first metacarpal" ; rdfs:subClassOf obo:HP_0009609, obo:HP_0010000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009616 obo:IAO_0000115 "Partial duplication of the first metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:06:17Z" ; oboInOwl:hasDbXref "UMLS:C4021423" ; oboInOwl:hasExactSynonym "Notched first long bone of hand", "partial duplication of the first metacarpal" ; oboInOwl:id "HP:0009616" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin (equivalent to the proximal phalanges of the other digits). This term applies if the first metacarpal is partially duplicated. Depending on the severity the appearance on x-ray can vary from a notched metacarpal (the duplicated bone is almost completely fused with the metacarpal) to a partially fused appearance of the two bones. In most cases the fused bone resembles a Y-shape." ; rdfs:label "Bifid first metacarpal" ; rdfs:subClassOf obo:HP_0009609, obo:HP_0010003 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009617 obo:IAO_0000115 "Any anomaly of the distal phalanx of thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:13:47Z" ; oboInOwl:hasAlternativeId "HP:0004081" ; oboInOwl:hasDbXref "UMLS:C4021422" ; oboInOwl:hasExactSynonym "Abnormality of terminal thumb phalanx", "Abnormality of the outermost bone of the thumb" ; oboInOwl:id "HP:0009617" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009602 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009618 obo:IAO_0000115 "An anomaly of the shape or form of the proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:13:47Z" ; oboInOwl:hasAlternativeId "HP:0004076" ; oboInOwl:hasDbXref "UMLS:C4021421" ; oboInOwl:hasExactSynonym "Abnormal innermost thumb bone", "Abnormality of proximal thumb phalanx" ; oboInOwl:id "HP:0009618" ; a owl:Class ; rdfs:comment "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; rdfs:label "Abnormality of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009602 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001195 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009620 oboInOwl:consider "HP:0009602" ; oboInOwl:id "HP:0009620" ; a owl:Class ; rdfs:label "obsolete Radial deviation of the thumb" ; owl:deprecated true . obo:HP_0009621 oboInOwl:consider "HP:0009602" ; oboInOwl:id "HP:0009621" ; a owl:Class ; rdfs:label "obsolete Ulnar deviation of the thumb" ; owl:deprecated true . obo:HP_0009622 obo:IAO_0000115 "Insertion of thumb at a more distal location than normal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:40:23Z" ; oboInOwl:hasAlternativeId "HP:0005755" ; oboInOwl:hasDbXref "UMLS:C4024270" ; oboInOwl:id "HP:0009622" ; a owl:Class ; rdfs:label "Distally placed thumb" ; rdfs:subClassOf obo:HP_0009603 . obo:HP_0009623 obo:IAO_0000115 "Proximal mislocalization of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:40:23Z" ; oboInOwl:hasAlternativeId "HP:0001170", "HP:0005668" ; oboInOwl:hasDbXref "UMLS:C1865572" ; oboInOwl:hasExactSynonym "Attachment of thumb close to wrist", "Low implantation of the thumb", "Low-set thumb", "Proximally placed thumbs" ; oboInOwl:id "HP:0009623" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Thumb placement index greater than 0.55; or, the base of the thumb appears closer to the wrist than is typical. The technique for the thumb placement index is described in detail [Malina et al., 1973; Hall et al., 2007]. Briefly, the thumb placement index is the distance from the proximal crease of the index finger to the angle of the first interdigital space divided by the distance from the proximal crease of the index finger to the wrist flexion crease at the base of the thumb. This term should not be used with Preaxial polydactyly." ; rdfs:label "Proximal placement of thumb" ; rdfs:subClassOf obo:HP_0009603 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002179 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009624 obo:IAO_0000115 "Chronic loss of joint motion of the carpometacarpal joint of the thumb due to structural changes in non-bony tissue. This joint is formed by the first metacarpal and the trapezial bone and is also called Articulatio carpometacarpalis pollicis, carpometacarpal articulation of thumb, carpometacarpal joint of thumb or first carpometacarpal articulation. Seldom referred to as thumb saddle joint." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4024269" ; oboInOwl:hasExactSynonym "Contracture of the carpometacarpal joint of the thumb" ; oboInOwl:id "HP:0009624" ; a owl:Class ; rdfs:label "Carpometacarpal thumb joint contracture" ; rdfs:subClassOf obo:HP_0009600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011265 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009625 obo:IAO_0000115 "Chronic loss of joint motion of the metacarpophalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio metacarpophalangealis pollicis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:52:18Z" ; oboInOwl:hasDbXref "UMLS:C2108151" ; oboInOwl:hasExactSynonym "Contracture of the metacarpophalangeal joint of the thumb" ; oboInOwl:id "HP:0009625" ; a owl:Class ; rdfs:label "Metacarpophalangeal thumb joint contracture" ; rdfs:subClassOf obo:HP_0009600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007735 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009626 obo:IAO_0000115 "Chronic loss of joint motion of the interphalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio interphalangealis pollicis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T04:52:18Z" ; oboInOwl:hasAlternativeId "HP:0005697" ; oboInOwl:hasDbXref "UMLS:C2108146" ; oboInOwl:hasExactSynonym "Contracture of the interphalangeal joint of the thumb", "Interphalangeal extension contractures of thumbs" ; oboInOwl:id "HP:0009626" ; a owl:Class ; rdfs:label "Interphalangeal thumb joint contracture" ; rdfs:subClassOf obo:HP_0001220, obo:HP_0009600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007723 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009629 obo:IAO_0000115 "This term applies if the proximal phalanx of the thumb is either small/hypoplastic or absent. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024268" ; oboInOwl:hasExactSynonym "Absent/small innermost thumb bone", "Absent/underdeveloped innermost thumb bone" ; oboInOwl:id "HP:0009629" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009658 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009630 obo:IAO_0000115 "Increased width of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024267" ; oboInOwl:hasExactSynonym "Broad innermost thumb bone" ; oboInOwl:id "HP:0009630" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009844, obo:HP_0009852, obo:HP_0011304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009631 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the thumb is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024266" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost thumb bone" ; oboInOwl:id "HP:0009631" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009652, obo:HP_0009845 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009632 obo:IAO_0000115 "A deviation from the normal straight shape of the proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024265" ; oboInOwl:hasExactSynonym "Curved innermost thumb bone" ; oboInOwl:id "HP:0009632" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009653, obo:HP_0009846, obo:HP_0009854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009633 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4021420" ; oboInOwl:hasExactSynonym "Osteolytic defects of the proximal phalanx of the thumb" ; oboInOwl:id "HP:0009633" ; a owl:Class ; rdfs:label "Osteolytic defect of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009654, obo:HP_0009847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009634 obo:IAO_0000115 "An uneven increase in bone density of the proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024264" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost thumb bone" ; oboInOwl:id "HP:0009634" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009655, obo:HP_0009848, obo:HP_0100913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009635 obo:IAO_0000115 "Fusion of a phalanx of the thumb with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasDbXref "UMLS:C4024263" ; oboInOwl:hasExactSynonym "Fusion of thumb bone" ; oboInOwl:id "HP:0009635" ; a owl:Class ; rdfs:label "Synostosis of thumb phalanx" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009849 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009636 obo:IAO_0000115 "Triangular shaped proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:09:41Z" ; oboInOwl:hasAlternativeId "HP:0004080" ; oboInOwl:hasDbXref "UMLS:C4021419" ; oboInOwl:hasExactSynonym "Triangular innermost thumb bone", "Triangular proximal thumb phalanx" ; oboInOwl:id "HP:0009636" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009618, obo:HP_0009657, obo:HP_0009850, obo:HP_0009858 . obo:HP_0009637 obo:IAO_0000115 "Absence of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:11:02Z" ; oboInOwl:hasAlternativeId "HP:0004077" ; oboInOwl:hasDbXref "UMLS:C4021418" ; oboInOwl:hasExactSynonym "Absent innermost thumb bone", "Absent ossification/absent proximal thumb phalanx", "Aplasia of the proximal phalanx of the thumb" ; oboInOwl:id "HP:0009637" ; a owl:Class ; rdfs:label "Absent proximal phalanx of thumb" ; rdfs:subClassOf obo:HP_0009629, obo:HP_0009659, obo:HP_0010239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009638 obo:IAO_0000115 "Hypoplastic (short) proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:11:02Z" ; oboInOwl:hasAlternativeId "HP:0004079", "HP:0006073" ; oboInOwl:hasDbXref "UMLS:C1855091" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the thumb", "Short proximal phalanges of thumb", "Short proximal thumb bone", "Short proximal thumb phalanx" ; oboInOwl:id "HP:0009638" ; a owl:Class ; rdfs:label "Short proximal phalanx of thumb" ; rdfs:subClassOf obo:HP_0005819, obo:HP_0009617, obo:HP_0009629, obo:HP_0009660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009640 obo:IAO_0000115 "Fusion of the proximal phalanx of the thumb with the 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:17:08Z" ; oboInOwl:hasDbXref "UMLS:C4024262" ; oboInOwl:hasExactSynonym "Ankylosis of the metacarpophalangeal joint of the thumb", "Fusion of the innermost bone of the thumb with the 1st long bone of hand" ; oboInOwl:id "HP:0009640" ; a owl:Class ; rdfs:label "Synostosis of the proximal phalanx of the thumb with the 1st metacarpal" ; rdfs:subClassOf obo:HP_0005880, obo:HP_0006152, obo:HP_0009635, obo:HP_0009703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009641 dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4024261" ; oboInOwl:hasExactSynonym "Absent/small outermost thumb bone", "Absent/underdeveloped outermost thumb bone" ; oboInOwl:id "HP:0009641" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617 . obo:HP_0009642 obo:IAO_0000115 "Increased width of the distal phalanx of thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasAlternativeId "HP:0004088", "HP:0006198" ; oboInOwl:hasDbXref "UMLS:C1863402" ; oboInOwl:hasExactSynonym "Broad outermost bone of the thumb", "Broad terminal thumb phalanx", "Wide distal phalanx of thumb", "Wide outermost bone of thumb" ; oboInOwl:id "HP:0009642" ; a owl:Class ; rdfs:label "Broad distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009836, obo:HP_0011304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009643 obo:IAO_0000115 "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the thumb is affected." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4024260" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the thumb" ; oboInOwl:id "HP:0009643" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009652, obo:HP_0009837 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009644 obo:IAO_0000115 "A deviation from the normal straight shape of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4024259" ; oboInOwl:hasExactSynonym "Curved outermost bone of the thumb" ; oboInOwl:id "HP:0009644" ; a owl:Class ; rdfs:label "Curved distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009653, obo:HP_0009838 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009645 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4021417" ; oboInOwl:hasExactSynonym "Osteolytic defects of the distal phalanx of the thumb", "Osteolytic defects of the outermost bone of the thumb" ; oboInOwl:id "HP:0009645" ; a owl:Class ; rdfs:label "Osteolytic defect of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009654, obo:HP_0009839 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009646 obo:IAO_0000115 "An uneven increase in bone density of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4024258" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the thumb" ; oboInOwl:id "HP:0009646" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009655, obo:HP_0009840, obo:HP_0100912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009648 obo:IAO_0000115 "Triangular shaped distal phalanx of the thumb. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4024257" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the thumb" ; oboInOwl:id "HP:0009648" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009617, obo:HP_0009657, obo:HP_0009875 . obo:HP_0009649 obo:IAO_0000115 "Absence of the distal/terminal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:22:06Z" ; oboInOwl:hasAlternativeId "HP:0004082" ; oboInOwl:hasDbXref "UMLS:C4021416" ; oboInOwl:hasExactSynonym "Absence of the outermost bone of the thumb", "Absent ossification/absent terminal thumb phalanx", "Aplasia of the outermost bone of the thumb" ; oboInOwl:id "HP:0009649" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009641, obo:HP_0009659, obo:HP_0009881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009650 obo:IAO_0000115 "Hypoplastic (short) distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:22:06Z" ; oboInOwl:hasAlternativeId "HP:0004085", "HP:0004087" ; oboInOwl:hasDbXref "UMLS:C1862313" ; oboInOwl:hasExactSynonym "Hypoplastic terminal thumb phalanx", "Hypoplastic/small distal phalanx of the thumb", "Short outermost bone of the thumb", "Short terminal thumb phalanx", "Short thumb terminal phalanx", "Small terminal thumb phalanx" ; oboInOwl:id "HP:0009650" ; a owl:Class ; rdfs:label "Short distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009641, obo:HP_0009660, obo:HP_0009882 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009652 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the thumb, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasDbXref "UMLS:C4021415" ; oboInOwl:hasExactSynonym "Bullet-shaped phalanges of the thumb", "Bullet-shaped thumb bone" ; oboInOwl:id "HP:0009652" ; a owl:Class ; rdfs:label "Bullet-shaped thumb phalanx" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0009769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009653 obo:IAO_0000115 "A deviation from the normal straight shape of a thumb phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasDbXref "UMLS:C4021414" ; oboInOwl:hasExactSynonym "Curved phalanges of the thumb", "Curved thumb bone" ; oboInOwl:id "HP:0009653" ; a owl:Class ; rdfs:label "Curved thumb phalanx" ; rdfs:subClassOf obo:HP_0004095, obo:HP_0009602, obo:HP_0009770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009654 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of one or more phalanges of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasDbXref "UMLS:C4020905" ; oboInOwl:hasExactSynonym "Osteolytic defects of the phalanges of the thumb" ; oboInOwl:id "HP:0009654" ; a owl:Class ; rdfs:comment "Osteolytic lesions are visible on radiography as demarcated areas of radiolucency ('darkness')." ; rdfs:label "Osteolytic defect of thumb phalanx" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0009771 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009655 obo:IAO_0000115 "An uneven increase in bone density of one or more of the phalanges of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasDbXref "UMLS:C4021413" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the thumb", "Uneven increase in bone density in thumb bone" ; oboInOwl:id "HP:0009655" ; a owl:Class ; rdfs:label "Patchy sclerosis of thumb phalanx" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009656 obo:IAO_0000115 "Congenital fusion (ankylosis) of the interphalangeal joint of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasAlternativeId "HP:0004068", "HP:0009639", "HP:0009647" ; oboInOwl:hasDbXref "UMLS:C1834032" ; oboInOwl:hasExactSynonym "Fused thumb bones", "Fused thumb phalanges", "Symphalangism of the distal and proximal phalanges of the thumb" ; oboInOwl:id "HP:0009656" ; a owl:Class ; rdfs:comment "Symphalangism is caused by a failure of segmentation that occurs during early fetal development." ; rdfs:label "Symphalangism of the thumb" ; rdfs:subClassOf obo:HP_0001204, obo:HP_0009617, obo:HP_0009635 . obo:HP_0009657 obo:IAO_0000115 "Abnormal shape of one or more phalanges of the thumb such that affected phalanges resemble a triangle." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasAlternativeId "HP:0004072" ; oboInOwl:hasDbXref "UMLS:C4021412" ; oboInOwl:hasExactSynonym "Triangular shaped phalanges of the thumb", "Triangular shaped thumb bone", "Triangular thumb phalanges" ; oboInOwl:id "HP:0009657" ; a owl:Class ; rdfs:comment "A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx (in this case metacarpal, see explanation above)." ; rdfs:label "Triangular shaped thumb phalanx" ; rdfs:subClassOf obo:HP_0009602 . obo:HP_0009658 dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:29:26Z" ; oboInOwl:hasAlternativeId "HP:0005834" ; oboInOwl:hasDbXref "UMLS:C4024256" ; oboInOwl:hasExactSynonym "Absent/small thumb bones", "Absent/underdeveloped thumb bones" ; oboInOwl:id "HP:0009658" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the thumb" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009659 obo:IAO_0000115 "The absence of a phalangeal segment of a thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:35:50Z" ; oboInOwl:hasAlternativeId "HP:0004065" ; oboInOwl:hasDbXref "UMLS:C4020780", "UMLS:C4024255" ; oboInOwl:hasExactSynonym "Partial absence of thumb" ; oboInOwl:hasRelatedSynonym "Aplasia of the phalanges of the thumb" ; oboInOwl:id "HP:0009659" ; a owl:Class ; rdfs:label "Partial absence of thumb" ; rdfs:subClassOf obo:HP_0009601, obo:HP_0009658 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009660 obo:IAO_0000115 "Hypoplastic (short) thumb phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:35:50Z" ; oboInOwl:hasAlternativeId "HP:0004069", "HP:0004071" ; oboInOwl:hasDbXref "UMLS:C4021411" ; oboInOwl:hasExactSynonym "Hypoplastic thumb phalanges", "Hypoplastic/small phalanges of the thumb", "Short thumb bone", "Short thumb phalanges" ; oboInOwl:id "HP:0009660" ; a owl:Class ; rdfs:label "Short phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009658, obo:HP_0009778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009662 obo:IAO_0000115 "Abnormality of the epiphysis of the distal phalanx of the thumb. This epiphysis is located on the proximal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:49:31Z" ; oboInOwl:hasAlternativeId "HP:0004089" ; oboInOwl:hasDbXref "UMLS:C4021410" ; oboInOwl:hasExactSynonym "Abnormality of terminal thumb epiphysis", "Abnormality of the end part of the outermost bone of the thumb" ; oboInOwl:id "HP:0009662" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0009617, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009663 obo:IAO_0000115 "This term applies if the epiphysis of the proximal phalanx of the thumb, which is located at the proximal end of the phalanx, does not appear in concordance with gender and age dependant norms as seen on x-rays. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-29T05:49:31Z" ; oboInOwl:hasDbXref "UMLS:C4024254" ; oboInOwl:hasExactSynonym "Abnormality of end part of thumb innermost long bone" ; oboInOwl:id "HP:0009663" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0009618, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009664 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024253" ; oboInOwl:hasExactSynonym "Absent end part of thumb innermost long bone" ; oboInOwl:id "HP:0009664" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009686, obo:HP_0010257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009665 obo:IAO_0000115 "An abnormality of the proximal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024252" ; oboInOwl:hasExactSynonym "Bracket shaped end part of thumb innermost long bone" ; oboInOwl:id "HP:0009665" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009687, obo:HP_0010258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009666 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the proximal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024251" ; oboInOwl:hasExactSynonym "Cone-shaped end part of thumb innermost long bone" ; oboInOwl:id "HP:0009666" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009688, obo:HP_0010259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009667 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024250" ; oboInOwl:hasExactSynonym "Enlarged end part of thumb innermost long bone" ; oboInOwl:id "HP:0009667" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009689, obo:HP_0010260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009668 obo:IAO_0000115 "Epiphysis of the proximal phalanx of the thumb having multiple bony fragments." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024249" ; oboInOwl:hasExactSynonym "Fragmentation of end part of thumb innermost long bone" ; oboInOwl:id "HP:0009668" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009690, obo:HP_0010261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009669 obo:IAO_0000115 "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024248" ; oboInOwl:hasExactSynonym "Irregular end part of thumb innermost long bone" ; oboInOwl:id "HP:0009669" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009691, obo:HP_0010262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009670 obo:IAO_0000115 "Sclerosis of the epiphysis of the proximal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024247" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the thumb" ; oboInOwl:id "HP:0009670" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009692, obo:HP_0010263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009671 obo:IAO_0000115 "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the proximal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024246" ; oboInOwl:id "HP:0009671" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009693, obo:HP_0010264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009672 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024245" ; oboInOwl:hasExactSynonym "Small end part of thumb innermost long bone" ; oboInOwl:id "HP:0009672" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009694, obo:HP_0010265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009673 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024244" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of thumb innermost long bone" ; oboInOwl:id "HP:0009673" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009695, obo:HP_0010266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009674 obo:IAO_0000115 "A triangular appearance of the epiphysis of the proximal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4024243" ; oboInOwl:hasExactSynonym "Triangular end part of thumb innermost long bone" ; oboInOwl:id "HP:0009674" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009663, obo:HP_0009696, obo:HP_0010267 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009675 obo:IAO_0000115 "Absence of the epiphysis located at the proximal end of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024242" ; oboInOwl:hasExactSynonym "Absent end part of thumb outermost long bone" ; oboInOwl:id "HP:0009675" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009686, obo:HP_0010246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009676 obo:IAO_0000115 "An abnormality of the distal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024241" ; oboInOwl:hasExactSynonym "Bracket shaped end part of thumb outermost long bone" ; oboInOwl:id "HP:0009676" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009687, obo:HP_0010247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009677 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the distal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasAlternativeId "HP:0004091" ; oboInOwl:hasDbXref "UMLS:C4021409" ; oboInOwl:hasExactSynonym "Cone-shaped end part of thumb outermost long bone", "Cone-shaped terminal thumb phalanx epiphysis" ; oboInOwl:id "HP:0009677" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009688, obo:HP_0010248 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009678 obo:IAO_0000115 "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasAlternativeId "HP:0004092" ; oboInOwl:hasDbXref "UMLS:C4021408" ; oboInOwl:hasExactSynonym "Enlarged end part of thumb outermost long bone", "Large terminal thumb phalanx epiphysis" ; oboInOwl:id "HP:0009678" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009689, obo:HP_0010249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009679 obo:IAO_0000115 "Epiphysis of the distal phalanx of the thumb having multiple bony fragments." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024240" ; oboInOwl:hasExactSynonym "Fragmentation of end part thumb outermost long bone" ; oboInOwl:id "HP:0009679" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009690, obo:HP_0010250 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009680 obo:IAO_0000115 "Uneven radiographic opacity of the epiphysis of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024239" ; oboInOwl:hasExactSynonym "Irregular end part of thumb outermost bone" ; oboInOwl:id "HP:0009680" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009691, obo:HP_0010251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009681 obo:IAO_0000115 "Sclerosis of the epiphysis of the distal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024238" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the thumb" ; oboInOwl:id "HP:0009681" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009692, obo:HP_0010252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009682 obo:IAO_0000115 "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024237" ; oboInOwl:hasExactSynonym "Pseudoepiphysis of the outermost bone of the thumb" ; oboInOwl:id "HP:0009682" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009693, obo:HP_0010253 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004337 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009683 obo:IAO_0000115 "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024236" ; oboInOwl:hasExactSynonym "Small end part of thumb outermost bone" ; oboInOwl:id "HP:0009683" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009694, obo:HP_0010254 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009684 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024235" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost thumb bone" ; oboInOwl:id "HP:0009684" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009695, obo:HP_0010255 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009685 obo:IAO_0000115 "A triangular appearance of the epiphysis of the distal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4024234" ; oboInOwl:hasExactSynonym "Triangular end part of thumb outermost bone", "Triangular epiphysis of the outermost bone of the thumb" ; oboInOwl:id "HP:0009685" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0009662, obo:HP_0009696, obo:HP_0010256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009686 obo:IAO_0000115 "Absence of one or more epiphyses of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4024233" ; oboInOwl:id "HP:0009686" ; a owl:Class ; rdfs:label "Absent epiphyses of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010228 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009687 obo:IAO_0000115 "An abnormality of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4024232" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the thumb bone" ; oboInOwl:id "HP:0009687" ; a owl:Class ; rdfs:label "Bracket epiphyses of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009688 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the thumb, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasAlternativeId "HP:0004075" ; oboInOwl:hasDbXref "UMLS:C4021407" ; oboInOwl:hasExactSynonym "Cone-shaped end part of thumb long bone", "Cone-shaped epiphyses of the thumb", "Cone-shaped thumb epiphyses" ; oboInOwl:id "HP:0009688" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010230 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009689 obo:IAO_0000115 "Abnormally large size of the epiphyses of the thumb with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021406" ; oboInOwl:hasExactSynonym "Enlarged end part of thumb long bone", "Enlarged epiphyses of the thumb" ; oboInOwl:id "HP:0009689" ; a owl:Class ; rdfs:label "Enlarged thumb epiphysis" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009690 obo:IAO_0000115 "Epiphysis of the thumb having multiple bony fragments." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021405" ; oboInOwl:hasExactSynonym "Fragmentation of end part of long bone of thumb", "Fragmentation of the epiphyses of the thumb" ; oboInOwl:id "HP:0009690" ; a owl:Class ; rdfs:label "Fragmentation of thumb epiphysis" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009691 obo:IAO_0000115 "Uneven radiographic opacity of the one or more epiphyses of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021404" ; oboInOwl:hasExactSynonym "Irregular end part of thumb long bone", "Irregular epiphyses of the thumb" ; oboInOwl:id "HP:0009691" ; a owl:Class ; rdfs:label "Irregular thumb epiphysis" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009692 obo:IAO_0000115 "Sclerosis of one or more of the epiphyses of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021403" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the thumb", "Ivory epiphyses of the thumb" ; oboInOwl:id "HP:0009692" ; a owl:Class ; rdfs:label "Ivory epiphysis of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010234, obo:HP_0100922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009693 obo:IAO_0000115 "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of one or more phalanges of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C3552484" ; oboInOwl:hasExactSynonym "Pseudoepiphyses of the thumb" ; oboInOwl:id "HP:0009693" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009694 obo:IAO_0000115 "Abnormally small size of one or more of the epiphyses of the thumb with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021402" ; oboInOwl:hasExactSynonym "Small end part of thumb long bone", "Small epiphyses of the thumb" ; oboInOwl:id "HP:0009694" ; a owl:Class ; rdfs:label "Small thumb epiphysis" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009695 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more of the epiphyses of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4021401" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of thumb bone", "Stippling of the epiphyses of the thumb" ; oboInOwl:id "HP:0009695" ; a owl:Class ; rdfs:label "Stippling of thumb epiphysis" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010237 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009696 dcterms:creator ; oboInOwl:creation_date "2009-01-30T09:20:16Z" ; oboInOwl:hasDbXref "UMLS:C4024231" ; oboInOwl:hasExactSynonym "Triangular end part of the thumb bone" ; oboInOwl:id "HP:0009696" ; a owl:Class ; rdfs:label "Triangular epiphyses of the thumb" ; rdfs:subClassOf obo:HP_0009599, obo:HP_0010238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009697 obo:IAO_0000115 "Chronic loss of joint motion in one or more distal interphalangeal joints of the fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:01:28Z" ; oboInOwl:hasDbXref "UMLS:C4024230" ; oboInOwl:id "HP:0009697" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the fingers" ; rdfs:subClassOf obo:HP_0001220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009699 dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:08:52Z" ; oboInOwl:hasAlternativeId "HP:0004282", "HP:0006082" ; oboInOwl:hasDbXref "UMLS:C4021400" ; oboInOwl:hasExactSynonym "Lytic defects of hand bones" ; oboInOwl:id "HP:0009699" ; a owl:Class ; rdfs:label "Osteolytic defects of the hand bones" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0045039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002797 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001442 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009700 obo:IAO_0000115 "An abnormal union between bones or parts of bones of the fingers. The synonymous term \"symphalangism of the hand\" may be translated as fusions of bones of varying digree, that involve at least one phalangeal bone of the hand. If bony fusions are referred to as \"Symphalangism\" the fusion occurs in a proximo-distal axis. Fusions of bones of the fingers in a radio-ulnar axis are referred to as \"bony\" Syndactyly." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:12:24Z" ; oboInOwl:hasDbXref "UMLS:C4021399" ; oboInOwl:hasExactSynonym "Fused finger bones", "Symphalangism of the hand", "Synostosis involving bones of the fingers" ; oboInOwl:id "HP:0009700" ; a owl:Class ; rdfs:label "Finger symphalangism" ; rdfs:subClassOf obo:HP_0004278, obo:HP_0100262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004249 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004249 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009701 obo:IAO_0000115 "Fusion involving two or more metacarpal bones (A synostosis of the first metacarpal and the proximal phalanx of the thumb can also be observed, note that the first metacarpal bone corresponds to a proximal phalanx)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:13:07Z" ; oboInOwl:hasAlternativeId "HP:0005915", "HP:0006041" ; oboInOwl:hasDbXref "UMLS:C4021398" ; oboInOwl:hasExactSynonym "Fused long bones of hand", "Synostosis involving metacarpal bones", "Synostosis involving the metacarpal bones" ; oboInOwl:id "HP:0009701" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Metacarpal synostosis" ; rdfs:subClassOf obo:HP_0004278, obo:HP_0005916, obo:HP_0100265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009702 obo:IAO_0000115 "Synostosis (bony fusion) involving one or more bones of the carpus (scaphoid, lunate, triquetrum, trapezium, trapezoid, capitate, hamate, pisiform)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:25:10Z" ; oboInOwl:hasAlternativeId "HP:0001192", "HP:0005799" ; oboInOwl:hasBroadSynonym "Fused wrist bones" ; oboInOwl:hasDbXref "SNOMEDCT_US:253930002", "UMLS:C0431863" ; oboInOwl:hasExactSynonym "Carpal bone fusion", "Carpal fusion", "Fused carpal bones", "Fusion of carpal bones", "Synostosis involving the carpal bones" ; oboInOwl:id "HP:0009702" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Carpal synostosis" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0004278, obo:HP_0100266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009703 obo:IAO_0000115 "Fusion of the 1st metacarpal with another bone. In contrast to the proximal phalanges of the digits 2 to 5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:26:41Z" ; oboInOwl:hasAlternativeId "HP:0005614", "HP:0010032" ; oboInOwl:hasDbXref "UMLS:C4021397" ; oboInOwl:hasExactSynonym "First metacarpophalangeal joint synostosis", "Fusion involving 1st long bone of hand", "Symphalangism affecting the 1st metacarpal" ; oboInOwl:id "HP:0009703" ; a owl:Class ; rdfs:label "Synostosis involving the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009704 obo:IAO_0000115 "Chronic cerebrospinal fluid (CSF) lymphocytosis is defined as the finding, in at least two serial CSF examinations, of more than 5 cells per cubic millimeter." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T06:24:59Z" ; oboInOwl:hasDbXref "UMLS:C4024229" ; oboInOwl:hasExactSynonym "Chronic cerebrospinal fluid lymphocytosis" ; oboInOwl:id "HP:0009704" ; a owl:Class ; rdfs:label "Chronic CSF lymphocytosis" ; rdfs:subClassOf obo:HP_0200149 . obo:HP_0009705 dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:32:03Z" ; oboInOwl:hasDbXref "UMLS:C4024228" ; oboInOwl:hasExactSynonym "Fusion involving the 2nd long bone of hand" ; oboInOwl:id "HP:0009705" ; a owl:Class ; rdfs:label "Synostosis involving the 2nd metacarpal" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0010010 . obo:HP_0009706 dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:32:03Z" ; oboInOwl:hasDbXref "UMLS:C4024227" ; oboInOwl:hasExactSynonym "Fusion involving the 3rd long bone of hand" ; oboInOwl:id "HP:0009706" ; a owl:Class ; rdfs:label "Synostosis involving the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0010011 . obo:HP_0009707 dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:32:03Z" ; oboInOwl:hasDbXref "UMLS:C4024226" ; oboInOwl:hasExactSynonym "Fusion involving the 4th long bone of hand" ; oboInOwl:id "HP:0009707" ; a owl:Class ; rdfs:label "Synostosis involving the 4th metacarpal" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0010012 . obo:HP_0009708 dcterms:creator ; oboInOwl:creation_date "2009-01-30T04:32:03Z" ; oboInOwl:hasDbXref "UMLS:C4024225" ; oboInOwl:hasExactSynonym "Fusion involving the 5th long bone of hand" ; oboInOwl:id "HP:0009708" ; a owl:Class ; rdfs:label "Synostosis involving the 5th metacarpal" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0010013 . obo:HP_0009709 obo:IAO_0000115 "Increased concentration of interferon alpha in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T06:27:06Z" ; oboInOwl:hasDbXref "UMLS:C1856983" ; oboInOwl:id "HP:0009709" ; a owl:Class ; rdfs:label "Increased CSF interferon alpha" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0009710 obo:IAO_0000115 "Chilblains, also called perniosis, are an inflammatory skin condition related to an abnormal vascular response to the cold. We are unaware of a reliable estimate of incidence. It typically presents as tender, pruritic red or bluish lesions located symmetrically on the dorsal aspect of the fingers, toes, ears and nose. Less commonly, reports describe involvement of the thighs and buttocks. The lesions present hours after exposure to cold and usually resolve spontaneously in one to three weeks." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T07:26:24Z" ; oboInOwl:hasDbXref "UMLS:C4024224" ; oboInOwl:hasExactSynonym "Chilblain lesions" ; oboInOwl:id "HP:0009710" ; a owl:Class ; rdfs:label "Chilblains" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0009711 obo:IAO_0000115 "A benign vascular tumor of the retina without any neoplastic characteristics." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T11:08:05Z" ; oboInOwl:hasDbXref "NCIT:C3801", "SNOMEDCT_US:312935003", "UMLS:C0730303", "UMLS:C1514915" ; oboInOwl:hasExactSynonym "Retinal hemangioblastoma" ; oboInOwl:id "HP:0009711" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Retinal capillary hemangioma" ; rdfs:subClassOf obo:HP_0001028, obo:HP_0009594, obo:HP_0010797 . obo:HP_0009713 obo:IAO_0000115 "A hemangioblastoma of the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T11:24:31Z" ; oboInOwl:hasDbXref "NCIT:C3801", "UMLS:C4024223" ; oboInOwl:id "HP:0009713" ; a owl:Class ; rdfs:label "Spinal hemangioblastoma" ; rdfs:subClassOf obo:HP_0010302, obo:HP_0010797 . obo:HP_0009714 obo:IAO_0000115 "An abnormality of the epididymis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T11:44:43Z" ; oboInOwl:hasDbXref "UMLS:C4024222" ; oboInOwl:hasExactSynonym "Abnormality of the epididymis" ; oboInOwl:id "HP:0009714" ; a owl:Class ; rdfs:comment "The epididymis is the structure that connects efferent ductules to vas deferens." ; rdfs:label "Abnormal epididymis morphology" ; rdfs:subClassOf obo:HP_0000022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001301 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009715 obo:IAO_0000115 "A cystadenoma, an epithelial tumor, that originates within the head of the epididymis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T11:46:33Z" ; oboInOwl:hasAlternativeId "HP:0030422" ; oboInOwl:hasDbXref "NCIT:C2974", "UMLS:C4024221" ; oboInOwl:id "HP:0009715" ; a owl:Class ; rdfs:comment "Papillary cystadenomas of the epididymis are partially or completely cystic or solid lesions, between 1-3 cm in diameter and arise from the efferent duct epithelium of the head of epididymis." ; rdfs:label "Papillary cystadenoma of the epididymis" ; rdfs:subClassOf obo:HP_0009714, obo:HP_0030421 . obo:HP_0009716 obo:IAO_0000115 "Small nodular masses which originate in the subependymal region of the lateral ventricles and protrude into the ventricular cavity. They may represent subependymal hamartomas of tuberous sclerosis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-30T11:57:28Z" ; oboInOwl:hasDbXref "UMLS:C1968958" ; oboInOwl:id "HP:0009716" ; a owl:Class ; rdfs:label "Subependymal nodules" ; rdfs:subClassOf obo:HP_0002118, obo:HP_0009731 . obo:HP_0009717 obo:IAO_0000115 "Cortical tubers in the brain are hamartomatous lesions typically located at the gray-white matter interface, commonly in the frontal and parietal lobes. Cortical tubers are composed of abnormal glial and neural cells, and the size, number, and location vary among patients." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:03:16Z" ; oboInOwl:hasDbXref "UMLS:C1968959" ; oboInOwl:id "HP:0009717" ; a owl:Class ; rdfs:label "Cortical tubers" ; rdfs:subClassOf obo:HP_0002538, obo:HP_0009731 . obo:HP_0009718 obo:IAO_0000115 "A demarcated, largely intraventricular tumor in the region of the foramen of Monro composed of spindle to large plump or ganglion-like cells with eosinophilic to amphophilic cytoplasm and somewhat pleomorphic nuclei with occasional prominent nucleoli. These tumors are almost always associated with tuberous sclerosis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:07:02Z" ; oboInOwl:hasDbXref "MSH:D001254", "SNOMEDCT_US:1586004", "SNOMEDCT_US:449799008", "UMLS:C0205768" ; oboInOwl:id "HP:0009718" ; a owl:Class ; rdfs:label "Subependymal giant-cell astrocytoma" ; rdfs:subClassOf obo:HP_0009592 . obo:HP_0009719 obo:IAO_0000115 "Hypomelanotic macules (\"ash leaf spots\") are white or lighter patches of skin that may appear anywhere on the body and are caused by a lack of melanin. White ash leaf-shaped macules are considered to be characteristic of tuberous sclerosis." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:16:52Z" ; oboInOwl:hasDbXref "UMLS:C4024220" ; oboInOwl:hasExactSynonym "Hypomelanotic macules" ; oboInOwl:id "HP:0009719" ; a owl:Class ; rdfs:comment "While hypopigmentation is a general term that refers to any form of decreased or absent skin pigmentation, hypomelanosis more specifically refers to a reduction of epidermal melanin." ; rdfs:label "Hypomelanotic macule" ; rdfs:subClassOf obo:HP_0001010, obo:HP_0020073 . obo:HP_0009720 obo:IAO_0000115 "The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:19:37Z" ; oboInOwl:hasDbXref "MSH:D014402", "SNOMEDCT_US:36025004", "SNOMEDCT_US:78424008", "UMLS:C0265319", "UMLS:C1368816" ; oboInOwl:hasExactSynonym "Facial angiofibromas", "Sebaceous adenoma" ; oboInOwl:hasRelatedSynonym "Sebaceous adenomas" ; oboInOwl:id "HP:0009720" ; a owl:Class ; rdfs:comment "Facial angiofibromas, also known as adenoma sebaceum, are reddish papillary lesions (fibrous skin tumors) that are found around the nose, cheeks, and chin and considered to be characteristic of tuberous sclerosis." ; rdfs:label "Adenoma sebaceum" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0010615, obo:HP_0011799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010615 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009721 obo:IAO_0000115 "A plaque representing a connective-tissue nevus. Connective tissue naevi are uncommon skin lesions that occur when the deeper layers of the skin do not develop correctly or the components of these layers occur in the wrong proportion. Shagreen patches are oval-shaped and nevoid, skin-colored or occasionally pigmented, smooth or crinkled. The word shagreen refers to a type of roughened untanned leather." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T09:36:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:254244007", "UMLS:C0432363" ; oboInOwl:id "HP:0009721" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Shagreen patch" ; rdfs:subClassOf obo:HP_0100898 . obo:HP_0009722 obo:IAO_0000115 "The presence of small depressions in the dental enamel." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T09:44:34Z" ; oboInOwl:hasDbXref "UMLS:C1860711" ; oboInOwl:hasExactSynonym "Dental enamel pits", "Dental enamel pitting", "Pitting of tooth enamel", "Tooth enamel pits" ; oboInOwl:id "HP:0009722" ; a owl:Class ; rdfs:label "Dental enamel pits" ; rdfs:subClassOf obo:HP_0000682 . obo:HP_0009723 obo:IAO_0000115 "A lesion located beneath a fingernail or toenail." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T09:49:06Z" ; oboInOwl:hasDbXref "UMLS:C4024219" ; oboInOwl:id "HP:0009723" ; a owl:Class ; rdfs:label "Abnormality of the subungual region" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009724 obo:IAO_0000115 "The presence of fibromata beneath finger or toenails." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T09:49:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:39295002", "UMLS:C0266003" ; oboInOwl:hasRelatedSynonym "Subungual fibroma" ; oboInOwl:id "HP:0009724" ; a owl:Class ; rdfs:label "Subungual fibromas" ; rdfs:subClassOf obo:HP_0009723, obo:HP_0010614 . obo:HP_0009725 obo:IAO_0000115 "The presence of a neoplasm of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:43:55Z" ; oboInOwl:hasDbXref "MSH:D001749", "NCIT:C3262", "SNOMEDCT_US:126885006", "UMLS:C0005695" ; oboInOwl:hasExactSynonym "Bladder cancer" ; oboInOwl:hasRelatedSynonym "Bladder tumor", "Bladder tumour" ; oboInOwl:id "HP:0009725" ; a owl:Class ; rdfs:label "Bladder neoplasm" ; rdfs:subClassOf obo:HP_0010786 . obo:HP_0009726 obo:IAO_0000115 "The presence of a neoplasm of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:41:48Z" ; oboInOwl:hasAlternativeId "HP:0005933" ; oboInOwl:hasBroadSynonym "Kidney cancer" ; oboInOwl:hasDbXref "MSH:D007680", "NCIT:C3262", "SNOMEDCT_US:126880001", "UMLS:C0022665", "UMLS:C1378703" ; oboInOwl:hasExactSynonym "Neoplasia of the kidneys", "Renal tumors", "Renal tumours" ; oboInOwl:hasRelatedSynonym "Renal neoplasia" ; oboInOwl:id "HP:0009726" ; a owl:Class ; rdfs:label "Renal neoplasm" ; rdfs:subClassOf obo:HP_0000077, obo:HP_0010786 . obo:HP_0009727 obo:IAO_0000115 "Areas of the retina lacking pigmentation. Punched out areas of chorioretinal hypopigmentation less than 1 disc diameter in size and tending to be located in the midperiphery of the retina." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:49:15Z" ; oboInOwl:hasDbXref "UMLS:C1860710" ; oboInOwl:hasExactSynonym "Punched out areas of chorioretinal hypopigmentation" ; oboInOwl:id "HP:0009727" ; a owl:Class ; rdfs:label "Achromatic retinal patches" ; rdfs:subClassOf obo:HP_0007894 . obo:HP_0009728 obo:IAO_0000115 "A benign or malignant neoplasm (tumor) originating in striated muscle, either skeletal muscle or cardiac muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:52:25Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4021396" ; oboInOwl:hasExactSynonym "Tumors of striated muscle", "Tumours of striated muscle" ; oboInOwl:id "HP:0009728" ; a owl:Class ; rdfs:label "Neoplasm of striated muscle" ; rdfs:subClassOf obo:HP_0003011, obo:HP_0011793 . obo:HP_0009729 obo:IAO_0000115 "A benign tumor of cardiac striated muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:53:11Z" ; oboInOwl:hasDbXref "UMLS:C1332852" ; oboInOwl:id "HP:0009729" ; a owl:Class ; rdfs:label "Cardiac rhabdomyoma" ; rdfs:subClassOf obo:HP_0009730, obo:HP_0100544 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009730 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009730 obo:IAO_0000115 "A benign tumor of striated muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:54:01Z" ; oboInOwl:hasDbXref "MSH:D012207", "NCIT:C3358", "SNOMEDCT_US:302846007", "SNOMEDCT_US:402877008", "SNOMEDCT_US:43375002", "UMLS:C0035411" ; oboInOwl:id "HP:0009730" ; a owl:Class ; rdfs:label "Rhabdomyoma" ; rdfs:subClassOf obo:HP_0009728 . obo:HP_0009731 obo:IAO_0000115 "The presence of a hamartoma of the cerebrum." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:02:09Z" ; oboInOwl:hasDbXref "UMLS:C4024218" ; oboInOwl:hasExactSynonym "Cerebral hamartomata" ; oboInOwl:id "HP:0009731" ; a owl:Class ; rdfs:comment "Hamartomatous lesions (benign focal lesions composed of disorganized tissue elements) affecting and sometimes originating from the cerebrum." ; rdfs:label "Cerebral hamartoma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100835 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009732 obo:IAO_0000115 "A neurofibroma in which Schwann cells proliferate inside the nerve sheath, producing an irregularly thickened, distorted, tortuous structure." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:12:32Z" ; oboInOwl:hasDbXref "MSH:D018318", "SNOMEDCT_US:403818001", "SNOMEDCT_US:41252002", "UMLS:C0206728" ; oboInOwl:id "HP:0009732" ; a owl:Class ; rdfs:label "Plexiform neurofibroma" ; rdfs:subClassOf obo:HP_0001067 . obo:HP_0009733 obo:IAO_0000115 "The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:15:22Z" ; oboInOwl:hasDbXref "MSH:D005910", "NCIT:C3059", "SNOMEDCT_US:115240006", "SNOMEDCT_US:393564001", "SNOMEDCT_US:74532006", "UMLS:C0017638" ; oboInOwl:id "HP:0009733" ; a owl:Class ; rdfs:comment "Gliomas can be classified as 1) ependymomas, 2) astrocytomas (including glioblastoma multiforme), 3 oligodendrogliomas, and 4) mixed gliomas, such as oligoastrocytomas." ; rdfs:label "Glioma" ; rdfs:subClassOf obo:HP_0030063, obo:HP_0100705, obo:HP_0100836 . obo:HP_0009734 obo:IAO_0000115 "A glioma originating in the optic nerve or optic chiasm." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:17:13Z" ; oboInOwl:hasDbXref "MSH:D020339", "SNOMEDCT_US:254976006", "SNOMEDCT_US:404662003", "UMLS:C0346326" ; oboInOwl:hasExactSynonym "Optic glioma" ; oboInOwl:id "HP:0009734" ; a owl:Class ; rdfs:label "Optic nerve glioma" ; rdfs:subClassOf obo:HP_0009733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009733 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009735 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the spine." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:19:24Z" ; oboInOwl:hasAlternativeId "HP:0007077" ; oboInOwl:hasDbXref "UMLS:C4024217" ; oboInOwl:hasExactSynonym "Spinal neurofibromas" ; oboInOwl:id "HP:0009735" ; a owl:Class ; rdfs:comment "Spinal neurofibromas can affect the spinal cord or the spinal nerve roots. Spinal neurofibromas can occur at cervical, thoracic, lumbar, and sacral levels." ; rdfs:label "Spinal neurofibroma" ; rdfs:subClassOf obo:HP_0034761 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001067 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009736 obo:IAO_0000115 "Pseudarthrosis, or \"false joint\" of the tibia is the result of a developmental failure in the tibia progressing to spontaneous fracture and subsequent fibrous nonunion. The fracture is rarely present at birth but commonly develops during the first 18 months of life." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:22:24Z" ; oboInOwl:hasDbXref "UMLS:C4024216" ; oboInOwl:hasExactSynonym "Tibial pseudoarthrosis" ; oboInOwl:id "HP:0009736" ; a owl:Class ; rdfs:label "Tibial pseudarthrosis" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0005864 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0005864 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009737 obo:IAO_0000115 "The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris.." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T11:45:04Z" ; oboInOwl:hasDbXref "UMLS:C1860334" ; oboInOwl:hasExactSynonym "Iris hamartomas" ; oboInOwl:id "HP:0009737" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lisch nodules" ; rdfs:subClassOf obo:HP_0010568, obo:HP_0034819 . obo:HP_0009738 obo:IAO_0000115 "An abnormality of the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:39:37Z" ; oboInOwl:hasDbXref "UMLS:C4021395" ; oboInOwl:hasExactSynonym "Abnormal antehelix", "Abnormal anthelix", "Abnormal antihelix" ; oboInOwl:id "HP:0009738" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "An abnormal form of the antihelix, which is the curved prominence of cartilage, parallel with and in front of the helix, and which divides into the crura antihelicis, between which is a triangular depression, the fossa triangularis." ; rdfs:label "Abnormal antihelix morphology" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009739 obo:IAO_0000115 "Developmental hypoplasia of the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:41:43Z" ; oboInOwl:hasDbXref "UMLS:C4021394" ; oboInOwl:hasExactSynonym "Hypoplastic antihelix" ; oboInOwl:id "HP:0009739" ; a owl:Class ; rdfs:label "Hypoplasia of the antihelix" ; rdfs:subClassOf obo:HP_0009738 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009740 obo:IAO_0000115 "Absence of the parotid gland." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T12:51:47Z" ; oboInOwl:hasDbXref "UMLS:C1400252", "UMLS:C4020779", "UMLS:C4024215" ; oboInOwl:hasExactSynonym "Abnormally small parotid gland", "Underdevelopment of parotid gland" ; oboInOwl:hasRelatedSynonym "Absence of the parotid gland", "Hypoplasia of parotid gland" ; oboInOwl:id "HP:0009740" ; a owl:Class ; rdfs:label "Aplasia of the parotid gland" ; rdfs:subClassOf obo:HP_0000197 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001831 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009741 obo:IAO_0000115 "Nephrosclerosis refers to thickening or scarring (\"sclerosis\") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T01:15:08Z" ; oboInOwl:hasDbXref "MSH:D009400", "SNOMEDCT_US:32916005", "UMLS:C0027719" ; oboInOwl:hasExactSynonym "Scarring of kidney arteries", "Thickening of kidney artiries" ; oboInOwl:id "HP:0009741" ; a owl:Class ; rdfs:label "Nephrosclerosis" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009742 obo:IAO_0000115 "Shoulder joint stiffness is a perceived sensation of tightness in shoulders when attempting to move them after a period of inactivity." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T02:02:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249918006", "UMLS:C0241042" ; oboInOwl:hasExactSynonym "Stiff shoulders" ; oboInOwl:id "HP:0009742" ; a owl:Class ; rdfs:label "Stiff shoulders" ; rdfs:subClassOf obo:HP_0001387, obo:HP_0033129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001545 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009743 obo:IAO_0000115 "Double rows of eyelashes." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T02:07:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95339000", "UMLS:C0423848" ; oboInOwl:hasExactSynonym "Distichiasis of eyelid eyelashes" ; oboInOwl:id "HP:0009743" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Distichiasis can be defined as the abnormal growth of lashes from the orifices of the Meibomian glands on the posterior lamella of the tarsal plate, resulting in a double row of eyelashes." ; rdfs:label "Distichiasis" ; rdfs:subClassOf obo:HP_0008496 . obo:HP_0009744 obo:IAO_0000115 "An abnormality of the spinal dura mater, which is the outermost of the three layers of the meninges surrounding the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T02:20:51Z" ; oboInOwl:hasDbXref "UMLS:C4024214" ; oboInOwl:hasExactSynonym "Abnormality of the spinal dura mater" ; oboInOwl:id "HP:0009744" ; a owl:Class ; rdfs:label "Abnormal spinal dura mater morphology" ; rdfs:subClassOf obo:HP_0010303, obo:HP_0010652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002093 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009745 obo:IAO_0000115 "Presence of arachnoid cysts of the spinal canal extradurally in the epidural space." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T02:22:38Z" ; oboInOwl:hasDbXref "UMLS:C4021393" ; oboInOwl:hasExactSynonym "Epidural arachnoid cysts of the spinal canal" ; oboInOwl:id "HP:0009745" ; a owl:Class ; rdfs:label "Spinal arachnoid cyst" ; rdfs:subClassOf obo:HP_0010303, obo:HP_0100702 . obo:HP_0009746 obo:IAO_0000115 "Abnormally increased thickness of the nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T02:44:09Z" ; oboInOwl:hasDbXref "UMLS:C1844810" ; oboInOwl:hasExactSynonym "Broad nasal septum", "Broad septum of nose", "Thick nasal septum", "Thick septum of nose", "Wide nasal septum", "Wide septum of nose" ; oboInOwl:id "HP:0009746" ; a owl:Class ; rdfs:label "Thick nasal septum" ; rdfs:subClassOf obo:HP_0000419 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009747 obo:IAO_0000115 "Abnormally increased hair growth in the lumbosacral region." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T03:21:52Z" ; oboInOwl:hasDbXref "UMLS:C1851095" ; oboInOwl:id "HP:0009747" ; a owl:Class ; rdfs:label "Lumbosacral hirsutism" ; rdfs:subClassOf obo:HP_0009889 . obo:HP_0009748 obo:IAO_0000115 "Increased volume of the earlobe, that is, abnormally prominent ear lobules." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T04:02:42Z" ; oboInOwl:hasAlternativeId "HP:0004449", "HP:0004456" ; oboInOwl:hasDbXref "UMLS:C1844573" ; oboInOwl:hasExactSynonym "Fleshy earlobe", "Fleshy earlobes", "Large earlobe", "Prominent ear lobes", "Prominent ear lobules" ; oboInOwl:id "HP:0009748" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "All gradations in size of the earlobe may be seen from absent to clearly enlarged compared to average. This finding is highly variable. Lobe size increases throughout adulthood." ; rdfs:label "Large earlobe" ; rdfs:subClassOf obo:HP_0000363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001847 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009751 obo:IAO_0000115 "Absence of the pectoralis major muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T05:18:55Z" ; oboInOwl:hasDbXref "UMLS:C4024213" ; oboInOwl:hasExactSynonym "Absent pectoralis major muscle" ; oboInOwl:id "HP:0009751" ; a owl:Class ; rdfs:label "Aplasia of the pectoralis major muscle" ; rdfs:subClassOf obo:HP_0005258, obo:HP_0100854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009752 obo:IAO_0000115 "A bony defect in the skull base." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T05:45:00Z" ; oboInOwl:hasDbXref "UMLS:C1856027" ; oboInOwl:hasExactSynonym "Cleft in cranial base", "Cleft in skull base" ; oboInOwl:id "HP:0009752" ; a owl:Class ; rdfs:label "Cleft in skull base" ; rdfs:subClassOf obo:HP_0002693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009754 obo:IAO_0000115 "Complete or nearly complete soft tissue fusion of the alveolar ridges." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T08:50:29Z" ; oboInOwl:hasDbXref "UMLS:C4021392" ; oboInOwl:hasExactSynonym "Alveolar synechiae", "Fusion of the alveolar ridges" ; oboInOwl:id "HP:0009754" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is associated with severely reduced mobility, or lack of mobility, between the upper and lower jaws. This finding is the severe end of a spectrum that includes oral synechiae." ; rdfs:label "Fibrous syngnathia" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0006477 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009755 obo:IAO_0000115 "Partial fusion of the upper and lower eyelid margins by single or multiple bands of tissue." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T08:52:59Z" ; oboInOwl:hasDbXref "MSH:C536373", "SNOMEDCT_US:193953008", "SNOMEDCT_US:400952003", "UMLS:C0339182", "UMLS:C1302999" ; oboInOwl:hasExactSynonym "Adhesion of eyelids", "Ankyloblepharon filiforme adnatum", "Eyelid synechiae", "Eyelids stuck together" ; oboInOwl:id "HP:0009755" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A minimally expressed form, especially when located fully laterally, may be more difficult to ascertain and would be a subjective feature. A band may break and leave no evidence of its presence. Note that the term is distinct from cryptophthalmos." ; rdfs:label "Ankyloblepharon" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0009756 obo:IAO_0000115 "A pterygium (or pterygia) occurring in the popliteal region (the back of the knee)." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T08:54:18Z" ; oboInOwl:hasDbXref "UMLS:C3805420" ; oboInOwl:id "HP:0009756" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Popliteal pterygium" ; rdfs:subClassOf obo:HP_0001059 . obo:HP_0009757 obo:IAO_0000115 "A pterygium (or pterygia) in the intercrural (groin) region." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T08:58:49Z" ; oboInOwl:hasDbXref "UMLS:C3810471" ; oboInOwl:id "HP:0009757" ; a owl:Class ; rdfs:label "Intercrural pterygium" ; rdfs:subClassOf obo:HP_0001059 . obo:HP_0009758 obo:IAO_0000115 "Pyramidal skinfold extending from the base to the top of the nails is a rare and distinctive anomaly seen in popliteal pterygia syndrome." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T09:08:49Z" ; oboInOwl:hasDbXref "UMLS:C4024212" ; oboInOwl:id "HP:0009758" ; a owl:Class ; rdfs:label "Pyramidal skinfold extending from the base to the top of the nails" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0009759 obo:IAO_0000115 "Pterygia affecting the neck." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:10:09Z" ; oboInOwl:hasDbXref "UMLS:C1849577" ; oboInOwl:hasExactSynonym "Neck pterygium" ; oboInOwl:id "HP:0009759" ; a owl:Class ; rdfs:label "Neck pterygia" ; rdfs:subClassOf obo:HP_0001059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001059 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000974 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009760 obo:IAO_0000115 "Pterygium affecting the elbow. This is a cutaneous web that can lead to severe flexion contracture of the elbow joint. Antecubital pterygium can be unilateral, bilateral, symmetric, or asysmmetric." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:12:24Z" ; oboInOwl:hasDbXref "MSH:C566738", "UMLS:C1867439" ; oboInOwl:hasExactSynonym "Pterygium cubitale", "Webbed elbow" ; oboInOwl:id "HP:0009760" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Antecubital pterygium" ; rdfs:subClassOf obo:HP_0001059 . obo:HP_0009761 obo:IAO_0000115 "Anterior schisis (cleft or cleavage) of vertebral bodies." ; dcterms:creator ; oboInOwl:creation_date "2009-01-31T10:40:39Z" ; oboInOwl:hasDbXref "UMLS:C1849579" ; oboInOwl:id "HP:0009761" ; a owl:Class ; rdfs:label "Anterior clefting of vertebral bodies" ; rdfs:subClassOf obo:HP_0008428 . obo:HP_0009762 obo:IAO_0000115 "Excessive wrinkling of the skin of the face." ; dcterms:creator ; oboInOwl:creation_date "2009-02-01T03:12:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:248194004", "UMLS:C0262478" ; oboInOwl:hasExactSynonym "Facial wrinkling" ; oboInOwl:id "HP:0009762" ; a owl:Class ; rdfs:label "Facial wrinkling" ; rdfs:subClassOf obo:HP_0100678 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001810 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009763 obo:IAO_0000115 "Chronic pain in the limbs with no clear focal etiology." ; dcterms:creator ; oboInOwl:creation_date "2009-02-01T03:55:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:90834002", "UMLS:C0030196" ; oboInOwl:hasExactSynonym "Limb pain" ; oboInOwl:hasRelatedSynonym "Pain in extremities" ; oboInOwl:id "HP:0009763" ; a owl:Class ; rdfs:label "Limb pain" ; rdfs:subClassOf obo:HP_0011843, obo:HP_0012531 . obo:HP_0009765 obo:IAO_0000115 "Columella extending inferior to the level of the nasal base, when viewed from the side." ; dcterms:creator ; oboInOwl:creation_date "2009-02-01T11:01:14Z" ; oboInOwl:hasAlternativeId "HP:0009766" ; oboInOwl:hasDbXref "UMLS:C1856119", "UMLS:C4280395" ; oboInOwl:hasExactSynonym "Columella, low", "Columella, low hanging", "Extension of the columella below the ala nasi", "Low-hanging columella" ; oboInOwl:hasRelatedSynonym "Columella extends below the ala nasi", "Prominent columella", "Rounded columella" ; oboInOwl:id "HP:0009765" ; a owl:Class ; rdfs:label "Low hanging columella" ; rdfs:subClassOf obo:HP_0009929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008341 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009767 obo:IAO_0000115 "Small or missing phalangeal bones of the fingers of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0006056", "HP:0006100", "HP:0009801" ; oboInOwl:hasDbXref "UMLS:C1848670" ; oboInOwl:hasExactSynonym "Aplastic/hypoplastic phalanges", "Aplastic/hypoplastic phalanges of the hand", "Hypoplastic/absent phalanges" ; oboInOwl:id "HP:0009767" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009768 obo:IAO_0000115 "Increased width of the phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0001246", "HP:0006260" ; oboInOwl:hasDbXref "UMLS:C4021391" ; oboInOwl:hasExactSynonym "Wide hand bones", "Widening of phalanges of the hand" ; oboInOwl:id "HP:0009768" ; a owl:Class ; rdfs:label "Broad phalanges of the hand" ; rdfs:subClassOf obo:HP_0001500, obo:HP_0005918, obo:HP_0006009, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009769 obo:IAO_0000115 "The presence of short and wide phalanges which taper distally (\"bullet shaped\")." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0004270", "HP:0006139" ; oboInOwl:hasDbXref "UMLS:C1854952" ; oboInOwl:hasExactSynonym "Bullet-shaped hand bones", "Bullet-shaped phalanges of the hands", "Conical bullet-shaped distal ends of phalanges" ; oboInOwl:id "HP:0009769" ; a owl:Class ; rdfs:label "Bullet-shaped phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009770 dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasDbXref "UMLS:C4024211" ; oboInOwl:hasExactSynonym "Curved hand bones" ; oboInOwl:id "HP:0009770" ; a owl:Class ; rdfs:label "Curved phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009771 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0001179" ; oboInOwl:hasDbXref "MSH:D030981", "SNOMEDCT_US:27201004", "SNOMEDCT_US:63122002", "UMLS:C0917990" ; oboInOwl:hasExactSynonym "Acro-osteolysis", "Acroosteolysis", "Breakdown of small bones of fingers" ; oboInOwl:id "HP:0009771" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918, obo:HP_0009699 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009772 obo:IAO_0000115 "Uneven (irregular) increase in bone density of one or more of the phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0006071" ; oboInOwl:hasDbXref "UMLS:C1857508" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the hand", "Phalangeal sclerosis", "Uneven increase in bone density in finger bone" ; oboInOwl:id "HP:0009772" ; a owl:Class ; rdfs:label "Patchy sclerosis of finger phalanx" ; rdfs:subClassOf obo:HP_0004286, obo:HP_0005686, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009773 obo:IAO_0000115 "Fusion of two or more phalangeal bones of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0006187", "HP:0006258" ; oboInOwl:hasDbXref "UMLS:C4021390" ; oboInOwl:hasExactSynonym "Fused finger bones of the hand", "Synostosis involving phalanges of the hand" ; oboInOwl:id "HP:0009773" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009774 dcterms:creator ; oboInOwl:creation_date "2009-02-02T11:38:04Z" ; oboInOwl:hasAlternativeId "HP:0006085", "HP:0009874" ; oboInOwl:hasDbXref "UMLS:C2673397" ; oboInOwl:hasExactSynonym "Delta phalanx/delta-like phalanx", "Triangular shaped hand bones" ; oboInOwl:id "HP:0009774" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009775 obo:IAO_0000115 "Annular constrictions around the digits, limbs, or trunk, occurring congenitally (sometimes causing intrauterine autoamputation) and also associated with a wide variety of disorders. Constrictive amniotic bands are the result of primary amniotic rupture, which can lead to entanglement of fetal tissue (especially limbs) in fibrous amniotic strands." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T05:36:41Z" ; oboInOwl:hasAlternativeId "HP:0001078" ; oboInOwl:hasDbXref "MSH:C535821", "MSH:D000652", "SNOMEDCT_US:19988008", "SNOMEDCT_US:238879003", "UMLS:C0334166", "UMLS:C1527388" ; oboInOwl:hasExactSynonym "Amniotic bands", "Congenital constriction band sequence", "Pseudoainhum" ; oboInOwl:hasRelatedSynonym "Amniotic constriction band" ; oboInOwl:id "HP:0009775" ; a owl:Class ; rdfs:comment "Pseudoainhum is a rare condition of unknown etiology that produces digital constricting rings, most commonly on the small fingers." ; rdfs:label "Amniotic constriction ring" ; rdfs:subClassOf obo:HP_0011409 . obo:HP_0009776 obo:IAO_0000115 "The absence of all phalanges of all the digits of a limb and the associated soft tissues." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T05:44:39Z" ; oboInOwl:hasBroadSynonym "Absent fingers or toes" ; oboInOwl:hasDbXref "Fyler:4173", "SNOMEDCT_US:275348004", "UMLS:C0238591", "UMLS:C4280394" ; oboInOwl:hasExactSynonym "Aphalangy" ; oboInOwl:id "HP:0009776" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This descriptor does not require absence of the metacarpal or metatarsal bones. A qualifying phrase is added to specify which limb has the attribute of adactyly." ; rdfs:label "Adactyly" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0010760 . obo:HP_0009777 obo:IAO_0000115 "Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T05:46:42Z" ; oboInOwl:hasAlternativeId "HP:0001185", "HP:0002802", "HP:0009627" ; oboInOwl:hasDbXref "UMLS:C3278811" ; oboInOwl:hasExactSynonym "Absent thumb", "Absent thumbs", "Aplasia of the thumb", "Thumb aplasia" ; oboInOwl:id "HP:0009777" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent thumb" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0009601 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009778 obo:IAO_0000115 "Hypoplasia (congenital reduction in size) of the thumb." ; dcterms:creator ; oboInOwl:creation_date "2009-02-02T05:46:42Z" ; oboInOwl:hasAlternativeId "HP:0001183", "HP:0001186", "HP:0001589", "HP:0005699", "HP:0006151", "HP:0009628" ; oboInOwl:hasDbXref "MSH:C536903", "SNOMEDCT_US:253936008", "UMLS:C0431890" ; oboInOwl:hasExactSynonym "Hypoplastic thumb", "Hypoplastic thumbs", "Hypoplastic/small thumb", "Short thumb", "Short thumbs", "Small thumbs", "Thumb brachydactyly", "Thumb hypoplasia" ; oboInOwl:id "HP:0009778" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short thumb" ; rdfs:subClassOf obo:HP_0009381, obo:HP_0009601 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009779 obo:IAO_0000115 "Syndactyly with fusion of toes three and four." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:43:16Z" ; oboInOwl:hasAlternativeId "HP:0004708" ; oboInOwl:hasDbXref "UMLS:C1834062" ; oboInOwl:hasExactSynonym "Webbed 3rd-4th toes", "syndactyly of 3rd - 4th toes" ; oboInOwl:id "HP:0009779" ; a owl:Class ; rdfs:label "3-4 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009780 obo:IAO_0000115 "Horn-like malformations of the iliac crests with symmetrical bilateral central posterior iliac processes. A characteristic finding in the Nail-Patella syndrome. Iliac horns are visible on X-ray and may be palpable, but are asymptomatic." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:48:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:84308008", "UMLS:C0263925" ; oboInOwl:id "HP:0009780" ; a owl:Class ; rdfs:label "Iliac horns" ; rdfs:subClassOf obo:HP_0003796 . obo:HP_0009781 obo:IAO_0000115 "A zone of darker pigmentation around the central part of the iris with a roughly cloverleaf or flower shape." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:50:17Z" ; oboInOwl:hasDbXref "UMLS:C4024210" ; oboInOwl:id "HP:0009781" ; a owl:Class ; rdfs:label "Lester's sign" ; rdfs:subClassOf obo:HP_0001100 . obo:HP_0009782 obo:IAO_0000115 "Absence or underdevelopment of the biceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:52:01Z" ; oboInOwl:hasDbXref "UMLS:C4024209" ; oboInOwl:hasExactSynonym "Absent/small biceps", "Absent/underdeveloped biceps" ; oboInOwl:id "HP:0009782" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the biceps" ; rdfs:subClassOf obo:HP_0001468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001507 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009783 obo:IAO_0000115 "Absence of the biceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:57:47Z" ; oboInOwl:hasDbXref "UMLS:C3805764" ; oboInOwl:hasExactSynonym "Absent biceps" ; oboInOwl:id "HP:0009783" ; a owl:Class ; rdfs:label "Biceps aplasia" ; rdfs:subClassOf obo:HP_0009782, obo:HP_0100854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001507 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009784 obo:IAO_0000115 "Absence or underdevelopment of the triceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T04:58:31Z" ; oboInOwl:hasDbXref "UMLS:C4024208" ; oboInOwl:hasExactSynonym "Absent/small triceps", "Absent/underdeveloped triceps" ; oboInOwl:id "HP:0009784" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the triceps" ; rdfs:subClassOf obo:HP_0001468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001509 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009785 obo:IAO_0000115 "Absence of the triceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:15:21Z" ; oboInOwl:hasDbXref "UMLS:C3810484" ; oboInOwl:hasExactSynonym "Absent triceps" ; oboInOwl:id "HP:0009785" ; a owl:Class ; rdfs:label "Triceps aplasia" ; rdfs:subClassOf obo:HP_0009784, obo:HP_0100854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001509 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009786 obo:IAO_0000115 "Absence or underdevelopment involving the musculature of the thigh." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:16:42Z" ; oboInOwl:hasDbXref "UMLS:C4024207" ; oboInOwl:hasExactSynonym "Absent/small thigh muscles", "Absent/underdeveloped thigh muscles" ; oboInOwl:id "HP:0009786" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the musculature of the thigh" ; rdfs:subClassOf obo:HP_0001441, obo:HP_0009128 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009787 obo:IAO_0000115 "Absence or underdevelopment of the quadriceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:17:40Z" ; oboInOwl:hasDbXref "UMLS:C4024206" ; oboInOwl:hasExactSynonym "Absent/small quadriceps", "Absent/underdeveloped quadriceps" ; oboInOwl:id "HP:0009787" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the quadriceps" ; rdfs:subClassOf obo:HP_0009786 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009788 obo:IAO_0000115 "Absence of the quadriceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:18:11Z" ; oboInOwl:hasDbXref "UMLS:C3805765" ; oboInOwl:hasExactSynonym "Absent quads" ; oboInOwl:id "HP:0009788" ; a owl:Class ; rdfs:label "Quadriceps aplasia" ; rdfs:subClassOf obo:HP_0009787, obo:HP_0100854 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009789 obo:IAO_0000115 "The presence of an abscess located around the anus." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:19:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:82127005", "UMLS:C0031019" ; oboInOwl:id "HP:0009789" ; a owl:Class ; rdfs:label "Perianal abscess" ; rdfs:subClassOf obo:HP_0031292, obo:HP_0034915 . obo:HP_0009790 obo:IAO_0000115 "A hemisacral defect involving the sacral vertebrae S2 to S5. In hemisacrum, the first sacral vertebra is intact and there is agenesis involving only S2-S5." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:21:37Z" ; oboInOwl:hasDbXref "UMLS:C2677632" ; oboInOwl:id "HP:0009790" ; a owl:Class ; rdfs:label "Hemisacrum" ; rdfs:subClassOf obo:HP_0008490 . obo:HP_0009791 obo:IAO_0000115 "Presence of a bifid sacral bone." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:22:25Z" ; oboInOwl:hasDbXref "UMLS:C4024204" ; oboInOwl:id "HP:0009791" ; a owl:Class ; rdfs:label "Bifid sacrum" ; rdfs:subClassOf obo:HP_0008490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009792 obo:IAO_0000115 "The presence of a teratoma." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:23:03Z" ; oboInOwl:hasDbXref "MSH:D013724", "NCIT:C3403", "SNOMEDCT_US:55818009", "UMLS:C0039538" ; oboInOwl:id "HP:0009792" ; a owl:Class ; rdfs:comment "Teratomas are germ-cell tumors commonly composed of multiple cell types derived from one or more of the three germ layers. They derive from embryonic pluripotent cells and may have various degrees of maturation, according to which they are classified as mature, immature, and malignant. Teratomas are found with decreasing frequency in the ovaries and testis, mediastinum, retroperitoneal space, sacrococcygeal zone, pineal and other intracranial locations." ; rdfs:label "Teratoma" ; rdfs:subClassOf obo:HP_0002898, obo:HP_0100728 . obo:HP_0009793 obo:IAO_0000115 "A type of sacrococcygeal teratoma located anterior to the sacrum and entirely inside the body (Altman type IV)." ; dcterms:creator ; oboInOwl:creation_date "2009-02-03T05:23:57Z" ; oboInOwl:hasDbXref "UMLS:C1867782" ; oboInOwl:hasExactSynonym "Altman type IV sacrococcygeal teratoma", "Retrorectal teratoma" ; oboInOwl:id "HP:0009793" ; a owl:Class ; rdfs:comment "Sacrococcygeal teratomas are thought to originate from multipotential cells in Henson's node, which migrates caudally to rest in the coccyx." ; rdfs:label "Presacral teratoma" ; rdfs:subClassOf obo:HP_0030736 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_718 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009794 obo:IAO_0000115 "Congenital developmental defect arising from the primitive branchial apparatus." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:16:20Z" ; oboInOwl:hasDbXref "UMLS:C1862066" ; oboInOwl:hasExactSynonym "Abnormality of branchial apparatus", "Abnormality of branchial arch", "Branchial abnormality", "Branchial anomalies" ; oboInOwl:id "HP:0009794" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "During embryonic development the major head and neck structures are formed from the five pharyngeal arches (bands of tissue). Incomplete, failed or persistent embryonic development of these arches results in several anomalies or defects in the neck." ; rdfs:label "Branchial anomaly" ; rdfs:subClassOf obo:HP_0025668 . obo:HP_0009795 obo:IAO_0000115 "A congenital fistula in the neck resulting from incomplete closure of a branchial cleft." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:17:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204268008", "UMLS:C0546968" ; oboInOwl:hasExactSynonym "Branchial cleft fistula" ; oboInOwl:id "HP:0009795" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Branchial fistula" ; rdfs:subClassOf obo:HP_0009794 . obo:HP_0009796 obo:IAO_0000115 "A branchial cyst is a remnant of embryonic development resulting from a failure of obliteration of a branchial cleft and consists of a subcutaneous cystic mass. Cysts are located anterior or posterior to the ear or in the submandibular region." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:18:08Z" ; oboInOwl:hasDbXref "MSH:D001935", "SNOMEDCT_US:42362005", "SNOMEDCT_US:59857007", "UMLS:C0006131" ; oboInOwl:hasExactSynonym "Branchial cysts" ; oboInOwl:hasRelatedSynonym "Branchial cleft cyst" ; oboInOwl:id "HP:0009796" ; a owl:Class ; rdfs:comment "Branchial cyst have to be distinguished from the preauricular cysts and sinuses, which are ectodermal remnants from an aberrant development of the auditory tubercles, tend to be bilateral, and are localized anterior to the tragus of the ear." ; rdfs:label "Branchial cyst" ; rdfs:subClassOf obo:HP_0009794 . obo:HP_0009797 obo:IAO_0000115 "Cholesteatoma is a benign but potentially destructive growth consisting of keratinizing epithelium located in the middle ear and/or mastoid process. In cholesteatoma, a skin cyst grows into the middle ear and mastoid. The cyst is not cancerous but can erode tissue and cause destruction of the ear." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:20:04Z" ; oboInOwl:hasDbXref "MSH:D002781", "SNOMEDCT_US:363668000", "SNOMEDCT_US:575006", "UMLS:C0008373" ; oboInOwl:id "HP:0009797" ; a owl:Class ; rdfs:label "Cholesteatoma" ; rdfs:subClassOf obo:HP_0008609, obo:HP_0100799 . obo:HP_0009798 obo:IAO_0000115 "A goiter that is not associated with functional thyroid abnormalities." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:21:23Z" ; oboInOwl:hasDbXref "MSH:C562732", "SNOMEDCT_US:32251000119106", "UMLS:C0302859" ; oboInOwl:hasExactSynonym "Euthyroid goitre" ; oboInOwl:id "HP:0009798" ; a owl:Class ; rdfs:label "Euthyroid goiter" ; rdfs:subClassOf obo:HP_0000853 . obo:HP_0009799 obo:IAO_0000115 "The presence of two or more accessory spleens." ; dcterms:creator ; oboInOwl:creation_date "2009-02-11T05:44:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:10362008", "UMLS:C0266631" ; oboInOwl:hasExactSynonym "Extra spleen" ; oboInOwl:id "HP:0009799" ; a owl:Class ; rdfs:label "Supernumerary spleens" ; rdfs:subClassOf obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009800 obo:IAO_0000115 "Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes." ; dcterms:creator ; oboInOwl:creation_date "2009-02-12T05:44:58Z" ; oboInOwl:hasDbXref "MSH:D016640", "SNOMEDCT_US:11687002", "UMLS:C0085207", "UMLS:C4020778" ; oboInOwl:hasExactSynonym "Maternal diabetes", "gestational diabetes" ; oboInOwl:hasNarrowSynonym "maternal hyperglycemia" ; oboInOwl:id "HP:0009800" ; a owl:Class ; rdfs:label "Maternal diabetes" ; rdfs:subClassOf obo:HP_0000819, obo:HP_0002686 . obo:HP_0009802 obo:IAO_0000115 "Absence of one or more of the phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-02-12T05:56:07Z" ; oboInOwl:hasDbXref "UMLS:C4024203", "UMLS:C4280393" ; oboInOwl:hasRelatedSynonym "Absent finger bone of the hand" ; oboInOwl:id "HP:0009802" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0009767, obo:HP_0009823 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009803 obo:IAO_0000115 "Short (hypoplastic) phalanx of finger, affecting one or more phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-02-12T05:57:11Z" ; oboInOwl:hasAlternativeId "HP:0001168", "HP:0005771", "HP:0006087", "HP:0006126" ; oboInOwl:hasDbXref "UMLS:C0877165" ; oboInOwl:hasExactSynonym "Hypoplastic phalanges", "Hypoplastic phalanges of hands", "Hypoplastic/small phalanges of the hand", "Phalangeal hypoplasia", "Rudimentary phalanges", "Short finger bones", "Short phalanges", "Shortened phalanges" ; oboInOwl:id "HP:0009803" ; a owl:Class ; rdfs:label "Short phalanx of finger" ; rdfs:subClassOf obo:HP_0009767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009804 obo:IAO_0000115 """The absence of one or more teeth from the normal series by a failure to develop""" ; oboInOwl:creation_date "2009-02-14T06:20:53Z" ; oboInOwl:hasDbXref "UMLS:C4024202", "UMLS:C4083050" ; oboInOwl:hasExactSynonym "Decreased tooth count", "Dental agenesis", "Failure of development of some teeth", "Reduced number of teeth", "Teeth, agenesis" ; oboInOwl:hasRelatedSynonym "Decreased number of teeth", "Fewer teeth than normal", "Missing some teeth" ; oboInOwl:id "HP:0009804" ; a owl:Class ; rdfs:comment "Teeth agenesis needs to be confirmed by X-rays. Teeth agenesis encompasses hypodontia, oligodontia, and anodontia. The total number and the type of teeth missing should be added to the description. The clinical absence of a tooth due to a disturbed eruption should not be termed teeth agenesis but a missing tooth." ; rdfs:label "Tooth agenesis" ; rdfs:subClassOf obo:HP_0006483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009805 obo:IAO_0000115 "A form of heart failure characterized by reduced cardiac output. This may be seen in patients with heart failure owing to ischemic heart disease, hypertension, cardiomyopathy, and other causes." ; dcterms:creator ; oboInOwl:creation_date "2009-02-16T11:10:18Z" ; oboInOwl:hasDbXref "UMLS:C4024201" ; oboInOwl:id "HP:0009805" ; a owl:Class ; rdfs:label "Low-output congestive heart failure" ; rdfs:subClassOf obo:HP_0001635 . obo:HP_0009806 obo:IAO_0000115 "A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP)." ; dcterms:creator ; oboInOwl:creation_date "2009-02-16T11:23:28Z" ; oboInOwl:hasDbXref "MSH:D018500", "SNOMEDCT_US:111395007", "UMLS:C0162283" ; oboInOwl:id "HP:0009806" ; a owl:Class ; rdfs:label "Nephrogenic diabetes insipidus" ; rdfs:subClassOf obo:HP_0000873 . obo:HP_0009808 obo:IAO_0000115 "A structural abnormality of a diaphysis of the arm." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T04:55:36Z" ; oboInOwl:hasAlternativeId "HP:0003857" ; oboInOwl:hasDbXref "UMLS:C4021389" ; oboInOwl:hasExactSynonym "Abnormality involving the diaphyses of the upper limbs", "Abnormality of shaft of long bone of the upper limbs", "Diaphyseal abnormality of the upper limbs" ; oboInOwl:id "HP:0009808" ; a owl:Class ; rdfs:label "Anomaly of the upper limb diaphyses" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012475 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009809 obo:IAO_0000115 "An anomaly of one or more metaphyses of the arms." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T04:55:36Z" ; oboInOwl:hasAlternativeId "HP:0003847" ; oboInOwl:hasDbXref "UMLS:C4021388" ; oboInOwl:hasExactSynonym "Abnormality of the wide portion of upper limb bone", "Abnormality of upper limb metaphysis", "Metaphyseal abnormality of the upper limbs" ; oboInOwl:id "HP:0009809" ; a owl:Class ; rdfs:label "Abnormal upper limb metaphysis morphology" ; rdfs:subClassOf obo:HP_0000944, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009810 dcterms:creator ; oboInOwl:creation_date "2009-02-23T04:57:56Z" ; oboInOwl:hasDbXref "UMLS:C4021387" ; oboInOwl:hasExactSynonym "Abnormality of the joints of the upper limbs", "Abnormality of upper limb joint" ; oboInOwl:id "HP:0009810" ; a owl:Class ; rdfs:label "Abnormality of upper limb joint" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009811 obo:IAO_0000115 "An anomaly of the joint that connects the upper and the lower arm." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T04:59:43Z" ; oboInOwl:hasAlternativeId "HP:0002966" ; oboInOwl:hasDbXref "UMLS:C4021386" ; oboInOwl:hasExactSynonym "Abnormality of the elbow", "Abnormality of the elbows" ; oboInOwl:id "HP:0009811" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the elbow" ; rdfs:subClassOf obo:HP_0009810 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001461 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009812 obo:IAO_0000115 "Amelia of one or both upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:06:12Z" ; oboInOwl:hasDbXref "UMLS:C4024200" ; oboInOwl:id "HP:0009812" ; a owl:Class ; rdfs:label "Amelia involving the upper limbs" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0009827 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009827 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009813 obo:IAO_0000115 "Missing or malformed long bones of the upper limbs with the distal parts (the hands) connected to the variably shortened or even absent upper extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the whole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia)." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:06:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253926000", "UMLS:C0265573" ; oboInOwl:id "HP:0009813" ; a owl:Class ; rdfs:label "Upper limb phocomelia" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0009829 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009829 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009814 obo:IAO_0000115 "Peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:06:12Z" ; oboInOwl:hasDbXref "UMLS:C4024199" ; oboInOwl:id "HP:0009814" ; a owl:Class ; rdfs:label "Upper limb peromelia" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0009828 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009828 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009815 obo:IAO_0000115 "Absence (due to failure to form) or underdevelopment of the extremities." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:06:40Z" ; oboInOwl:hasAlternativeId "HP:0002969", "HP:0006497" ; oboInOwl:hasDbXref "UMLS:C0239399" ; oboInOwl:hasExactSynonym "Absent/small extremities", "Absent/underdeveloped extremities", "Short or absent limbs", "Shortened limbs" ; oboInOwl:id "HP:0009815" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the extremities" ; rdfs:subClassOf obo:HP_0009115, obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009816 obo:IAO_0000115 "Leg shortening because of underdevelopment of one or more bones of the lower extremity." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:09:32Z" ; oboInOwl:hasAlternativeId "HP:0003087", "HP:0005884", "HP:0006399" ; oboInOwl:hasDbXref "SNOMEDCT_US:253959002", "UMLS:C0345371" ; oboInOwl:hasExactSynonym "Hypoplasia involving bones of the lower limbs", "Hypoplasia of the lower limbs", "Lower limb undergrowth", "Underdeveloped lower limb bones" ; oboInOwl:id "HP:0009816" ; a owl:Class ; rdfs:label "Lower limb undergrowth" ; rdfs:subClassOf obo:HP_0006493, obo:HP_0009826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009817 dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:10:03Z" ; oboInOwl:hasDbXref "UMLS:C4024198" ; oboInOwl:hasExactSynonym "Absent bones of the lower limbs" ; oboInOwl:id "HP:0009817" ; a owl:Class ; rdfs:label "Aplasia involving bones of the lower limbs" ; rdfs:subClassOf obo:HP_0006493, obo:HP_0009825 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009818 obo:IAO_0000115 "Amelia of one or both legs." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:11:07Z" ; oboInOwl:hasDbXref "UMLS:C4024197" ; oboInOwl:id "HP:0009818" ; a owl:Class ; rdfs:label "Amelia involving the lower limbs" ; rdfs:subClassOf obo:HP_0006493, obo:HP_0009827 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009827 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009819 obo:IAO_0000115 "Phocomelia affecting only the lower limbs." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:11:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253963009", "UMLS:C0265625" ; oboInOwl:id "HP:0009819" ; a owl:Class ; rdfs:label "Lower limb phocomelia" ; rdfs:subClassOf obo:HP_0006493, obo:HP_0009829 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009829 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009820 obo:IAO_0000115 "Peromelia affecting only the lower limbs. That is, the distal parts of the leg are missing leading to stump formation." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:11:07Z" ; oboInOwl:hasDbXref "UMLS:C4024196" ; oboInOwl:id "HP:0009820" ; a owl:Class ; rdfs:label "Lower limb peromelia" ; rdfs:subClassOf obo:HP_0006494, obo:HP_0009828 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009828 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009821 obo:IAO_0000115 "Forearm shortening because of underdevelopment of one or more bones of the forearm." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:11:42Z" ; oboInOwl:hasAlternativeId "HP:0003024", "HP:0003968", "HP:0006405" ; oboInOwl:hasDbXref "UMLS:C1855299" ; oboInOwl:hasExactSynonym "Forearm undergrowth", "Hypoplasia involving forearm bones", "Short forearm bones", "Short forearms", "Shortened forearm" ; oboInOwl:id "HP:0009821" ; a owl:Class ; rdfs:label "Forearm undergrowth" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0006503, obo:HP_0009824, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009822 dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:12:10Z" ; oboInOwl:hasDbXref "UMLS:C4024195" ; oboInOwl:hasExactSynonym "Absent forearm bones" ; oboInOwl:id "HP:0009822" ; a owl:Class ; rdfs:label "Aplasia involving forearm bones" ; rdfs:subClassOf obo:HP_0006503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009823 dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:13:20Z" ; oboInOwl:hasDbXref "UMLS:C4024194" ; oboInOwl:hasExactSynonym "Absent bones of the upper limbs" ; oboInOwl:id "HP:0009823" ; a owl:Class ; rdfs:label "Aplasia involving bones of the upper limbs" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0009825 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009824 obo:IAO_0000115 "Arm shortening because of underdevelopment of one or more bones of the upper extremity." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:13:20Z" ; oboInOwl:hasAlternativeId "HP:0003056", "HP:0006364" ; oboInOwl:hasDbXref "UMLS:C1837406" ; oboInOwl:hasExactSynonym "Hypoplasia involving bones of the upper limbs", "Short arms", "Shortening of the arms", "Upper limb undergrowth" ; oboInOwl:id "HP:0009824" ; a owl:Class ; rdfs:label "Upper limb undergrowth" ; rdfs:subClassOf obo:HP_0006496, obo:HP_0009826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009825 dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:16:44Z" ; oboInOwl:hasDbXref "UMLS:C4024193" ; oboInOwl:hasExactSynonym "Absent bones of the extremities" ; oboInOwl:id "HP:0009825" ; a owl:Class ; rdfs:label "Aplasia involving bones of the extremities" ; rdfs:subClassOf obo:HP_0045060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009826 obo:IAO_0000115 "Limb shortening because of underdevelopment of one or more bones of the extremities." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:16:44Z" ; oboInOwl:hasAlternativeId "HP:0003058", "HP:0005049", "HP:0005057" ; oboInOwl:hasDbXref "UMLS:C0239399" ; oboInOwl:hasExactSynonym "Hypoplasia involving bones of the extremities", "Limb undergrowth", "Short limb", "Short limbs", "limb shortening" ; oboInOwl:id "HP:0009826" ; a owl:Class ; rdfs:label "Limb undergrowth" ; rdfs:subClassOf obo:HP_0009815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009827 obo:IAO_0000115 "Congenital absence (aplasia) of one or more limbs." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:17:25Z" ; oboInOwl:hasDbXref "MEDDRA:10001926", "MSH:D004480", "SNOMEDCT_US:62588002", "UMLS:C0002447" ; oboInOwl:id "HP:0009827" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Amelia" ; rdfs:subClassOf obo:HP_0009815 . obo:HP_0009828 obo:IAO_0000115 "The distal parts of the limbs are missing leading to a stump formation." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:17:25Z" ; oboInOwl:hasDbXref "UMLS:C4024192" ; oboInOwl:id "HP:0009828" ; a owl:Class ; rdfs:label "Peromelia" ; rdfs:subClassOf obo:HP_0009815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004288 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009829 obo:IAO_0000115 "Missing or malformed long bones of the extremities with the distal parts (such as hands and/or feet) connected to the variably shortened or even absent extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the hole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia)." ; dcterms:creator ; oboInOwl:creation_date "2009-02-23T05:17:25Z" ; oboInOwl:hasAlternativeId "HP:0002994" ; oboInOwl:hasDbXref "MEDDRA:10034923", "MSH:D004480", "SNOMEDCT_US:22841008", "UMLS:C0031575" ; oboInOwl:id "HP:0009829" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Phocomelia" ; rdfs:subClassOf obo:HP_0009815, obo:HP_0011314 . obo:HP_0009830 obo:IAO_0000115 "Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course." ; dcterms:creator ; oboInOwl:creation_date "2009-03-01T07:49:18Z" ; oboInOwl:hasAlternativeId "HP:0003157", "HP:0003407", "HP:0007088", "HP:0007235", "HP:0007355" ; oboInOwl:hasDbXref "MSH:D010523", "SNOMEDCT_US:302226006", "SNOMEDCT_US:386033004", "SNOMEDCT_US:42658009", "UMLS:C0031117", "UMLS:C0442874" ; oboInOwl:hasExactSynonym "Peripheral nerve damage", "Peripheral neuritis" ; oboInOwl:hasRelatedSynonym "Neuropathy" ; oboInOwl:id "HP:0009830" ; a owl:Class ; rdfs:comment "Terms from this subhierarchy should be used to describe morphological abnormalities seen in peripheral neuropathy. Functional deficits should be coded separately." ; rdfs:label "Peripheral neuropathy" ; rdfs:subClassOf obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009831 obo:IAO_0000115 "A focal lesion of a single peripheral nerve. Damage to a sensory nerve is accompanied by sensory impairment of all modalities in the affected anatomic distribution." ; dcterms:creator ; oboInOwl:creation_date "2009-03-01T08:27:29Z" ; oboInOwl:hasDbXref "MSH:D020422", "SNOMEDCT_US:128189008", "UMLS:C0494491" ; oboInOwl:hasExactSynonym "Single damaged nerve" ; oboInOwl:id "HP:0009831" ; a owl:Class ; rdfs:label "Mononeuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0009832 obo:IAO_0000115 "Any anomaly of distal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:01:39Z" ; oboInOwl:hasAlternativeId "HP:0005919" ; oboInOwl:hasDbXref "UMLS:C4021385" ; oboInOwl:hasExactSynonym "Abnormal terminal phalanges of the hand", "Abnormality of the distal phalanges of the hand", "Abnormality of the distal phalanx of finger", "Abnormality of the outermost finger bone" ; oboInOwl:id "HP:0009832" ; a owl:Class ; rdfs:label "Abnormal distal phalanx morphology of finger" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009833 obo:IAO_0000115 "An anomaly of middle phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:01:39Z" ; oboInOwl:hasDbXref "UMLS:C4024191" ; oboInOwl:hasExactSynonym "Abnormality of the middle finger bones of the hand", "Abnormality of the middle phalanges of the hand" ; oboInOwl:id "HP:0009833" ; a owl:Class ; rdfs:label "Abnormal middle phalanx morphology of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009834 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:01:39Z" ; oboInOwl:hasDbXref "UMLS:C4024190" ; oboInOwl:hasExactSynonym "Abnormality of the innermost finger bones of the hand", "Abnormality of the proximal phalanges of the hand" ; oboInOwl:id "HP:0009834" ; a owl:Class ; rdfs:label "Abnormal proximal phalanx morphology of the hand" ; rdfs:subClassOf obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009835 obo:IAO_0000115 "Absence or underdevelopment of the distal phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0005635", "HP:0006037", "HP:0006066", "HP:0006235" ; oboInOwl:hasDbXref "UMLS:C1861336" ; oboInOwl:hasExactSynonym "Absent/hypoplastic distal phalanges", "Absent/small outermost finger bone of the hand", "Absent/underdeveloped outermost finger bone of the hand", "Aplasia/Hypoplasia of the distal phalanges", "Aplastic/hypoplastic distal phalanges", "Hypoplastic to absent terminal phalanges", "Hypoplastic/aplastic distal phalanges", "Hypoplastic/aplastic distal phalanx" ; oboInOwl:hasRelatedSynonym "Small or absent distal phalanges" ; oboInOwl:id "HP:0009835" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009767, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009836 obo:IAO_0000115 "Abnormally wide (broad) distal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0003120", "HP:0006113", "HP:0006197", "HP:0006241", "HP:0009859" ; oboInOwl:hasDbXref "UMLS:C1850630" ; oboInOwl:hasExactSynonym "Broad distal phalanges", "Broad distal phalanges of the hand", "Broad distal phalanx", "Broad outermost finger bone", "Broad terminal phalanges", "Broad, square ends of distal phalanges", "Spatulate terminal phalanges" ; oboInOwl:id "HP:0009836" ; a owl:Class ; rdfs:comment "This term should be reserved for a radiological finding of increased width of the distal finger phalanx (bone). The term Broad fingertip should be used to denote a clinical impression of increased side to side width of the distance part of the finger." ; rdfs:label "Broad distal phalanx of finger" ; rdfs:subClassOf obo:HP_0009768, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009837 obo:IAO_0000115 "Short and wide distal phalanges that taper distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0009860" ; oboInOwl:hasDbXref "UMLS:C4024189" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost finger bone of the hand" ; oboInOwl:id "HP:0009837" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009769, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009838 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0009862" ; oboInOwl:hasDbXref "UMLS:C4024188" ; oboInOwl:hasExactSynonym "Curved outermost finger bone of the hand" ; oboInOwl:id "HP:0009838" ; a owl:Class ; rdfs:label "Curved distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009770, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009839 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0001219", "HP:0009865" ; oboInOwl:hasDbXref "UMLS:C1849547" ; oboInOwl:hasExactSynonym "Acro-osteolysis of distal phalanges", "Acroosteolysis of distal phalanges", "Osteolytic defects of the outermost finger bone of the hand" ; oboInOwl:id "HP:0009839" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009771, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009840 obo:IAO_0000115 "Uneven (irregular) increase in bone density of the distal phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:10:11Z" ; oboInOwl:hasAlternativeId "HP:0009868" ; oboInOwl:hasDbXref "UMLS:C4021384" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the distal phalanges of the hand", "Uneven increase in bone density in outermost finger bone" ; oboInOwl:id "HP:0009840" ; a owl:Class ; rdfs:label "Patchy sclerosis of distal phalanx of finger" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009843 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0005810", "HP:0006063", "HP:0006148" ; oboInOwl:hasDbXref "UMLS:C1862152" ; oboInOwl:hasExactSynonym "Absent/hypoplastic middle phalanges", "Absent/small middle finger bone of the hand", "Absent/underdeveloped middle finger bone of the hand", "Aplasia/hypoplasia of middle phalanges", "Aplastic/hypoplastic middle phalanges", "Hypoplastic/aplastic middle phalanx", "Short to absent middle phalanges", "Short/absent middle phalanges" ; oboInOwl:id "HP:0009843" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009767, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009844 obo:IAO_0000115 "Increased width of the middle phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasDbXref "UMLS:C4021383" ; oboInOwl:hasExactSynonym "Broad middle finger bones", "Broad middle phalanges of finger", "Broad middle phalanges of the hand" ; oboInOwl:id "HP:0009844" ; a owl:Class ; rdfs:label "Broad middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009768, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009845 obo:IAO_0000115 "Any of the middle phalanges with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0006038" ; oboInOwl:hasDbXref "UMLS:C4024187" ; oboInOwl:id "HP:0009845" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009769, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009846 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0009863" ; oboInOwl:hasDbXref "UMLS:C4024186" ; oboInOwl:hasExactSynonym "Curved middle finger bonds of the hand" ; oboInOwl:id "HP:0009846" ; a owl:Class ; rdfs:label "Curved middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009770, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009847 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0009866" ; oboInOwl:hasDbXref "UMLS:C4024185" ; oboInOwl:id "HP:0009847" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009771, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009848 obo:IAO_0000115 "Uneven (irregular) increase in bone density of one or more of the middle phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0009870" ; oboInOwl:hasDbXref "UMLS:C4021382" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the middle phalanges of the hand", "Uneven increase in bone density in the middle finger bones of the hand" ; oboInOwl:id "HP:0009848" ; a owl:Class ; rdfs:label "Patchy sclerosis of middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009849 obo:IAO_0000115 "Fusion of a middle phalanx of a finger with another bone." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0009872" ; oboInOwl:hasDbXref "UMLS:C4024184" ; oboInOwl:hasExactSynonym "Fused middle finger bone" ; oboInOwl:id "HP:0009849" ; a owl:Class ; rdfs:label "Symphalangism of middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009773, obo:HP_0009833 . obo:HP_0009850 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:15:55Z" ; oboInOwl:hasAlternativeId "HP:0009876" ; oboInOwl:hasDbXref "UMLS:C4024183" ; oboInOwl:hasExactSynonym "Triangular shaped middle finger bones of the hand" ; oboInOwl:id "HP:0009850" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009774, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009851 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasDbXref "UMLS:C4024182" ; oboInOwl:hasExactSynonym "Absent/small innermost finger bones of the hand", "Absent/underdeveloped innermost finger bones of the hand" ; oboInOwl:id "HP:0009851" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009767, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009852 obo:IAO_0000115 "Increased width of the proximal phalanges of the finger." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0006168" ; oboInOwl:hasDbXref "UMLS:C4024181" ; oboInOwl:hasExactSynonym "Broad innermost finger bones of the hand", "Wide innermost finger bones of the hand" ; oboInOwl:id "HP:0009852" ; a owl:Class ; rdfs:label "Broad proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009768, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009853 obo:IAO_0000115 "Short and wide proximal phalanges that taper distally . Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0009861" ; oboInOwl:hasDbXref "UMLS:C4024180" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost finger bones of the hand" ; oboInOwl:id "HP:0009853" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009769, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009854 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0009864" ; oboInOwl:hasDbXref "UMLS:C4024179" ; oboInOwl:hasExactSynonym "Curved innermost finger bones of the hand" ; oboInOwl:id "HP:0009854" ; a owl:Class ; rdfs:label "Curved proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009770, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009855 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0006050", "HP:0009867" ; oboInOwl:hasDbXref "UMLS:C1850148" ; oboInOwl:hasExactSynonym "Proximal phalanges osteolysis" ; oboInOwl:id "HP:0009855" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009771, obo:HP_0009834 . obo:HP_0009856 obo:IAO_0000115 "Uneven increase in bone density of the proximal phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0009869" ; oboInOwl:hasDbXref "UMLS:C4021381" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the proximal phalanges of the hand", "Uneven increase in bone density in innermost finger bone" ; oboInOwl:id "HP:0009856" ; a owl:Class ; rdfs:label "Patchy sclerosis of proximal phalanx of finger" ; rdfs:subClassOf obo:HP_0009772, obo:HP_0100917 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0009857 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0009873" ; oboInOwl:hasDbXref "UMLS:C4024178" ; oboInOwl:hasExactSynonym "Fused innermost hand bones" ; oboInOwl:id "HP:0009857" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009773, obo:HP_0009834 . obo:HP_0009858 dcterms:creator ; oboInOwl:creation_date "2009-03-11T12:16:33Z" ; oboInOwl:hasAlternativeId "HP:0009877" ; oboInOwl:hasDbXref "UMLS:C4024177" ; oboInOwl:hasRelatedSynonym "Triangular shaped innermost finger bone" ; oboInOwl:id "HP:0009858" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009774, obo:HP_0009834 . obo:HP_0009875 dcterms:creator ; oboInOwl:creation_date "2009-03-11T01:53:07Z" ; oboInOwl:hasAlternativeId "HP:0006061", "HP:0009842" ; oboInOwl:hasDbXref "UMLS:C4024176" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the hand" ; oboInOwl:id "HP:0009875" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009774, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009878 obo:IAO_0000115 "The presence of cerebellar signs and symptoms such as lack of balance associated with quadrupedal gait (locomotion on all four extremities with a 'bear-like' gait with the legs held straight)." ; oboInOwl:creation_date "2009-03-28T05:22:45Z" ; oboInOwl:hasDbXref "UMLS:C4024175" ; oboInOwl:id "HP:0009878" ; a owl:Class ; rdfs:label "Cerebellar ataxia associated with quadrupedal gait" ; rdfs:subClassOf obo:HP_0001251, obo:HP_0001288 . obo:HP_0009879 obo:IAO_0000115 "An abnormality of the cerebral cortex with fewer gyri but with normal cortical thickness. This pattern is usually often associated with congenital microcephaly." ; oboInOwl:creation_date "2009-03-28T06:23:59Z" ; oboInOwl:hasDbXref "UMLS:C2749675" ; oboInOwl:hasExactSynonym "Cortical gyral simplification" ; oboInOwl:id "HP:0009879" ; a owl:Class ; rdfs:label "Simplified gyral pattern" ; rdfs:subClassOf obo:HP_0002536 . obo:HP_0009880 obo:IAO_0000115 "Abnormally wide (broad) distal phalanx of finger of all fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-04-24T04:18:59Z" ; oboInOwl:hasAlternativeId "HP:0005816" ; oboInOwl:hasDbXref "UMLS:C4024174" ; oboInOwl:hasExactSynonym "Broad outermost hand bones" ; oboInOwl:id "HP:0009880" ; a owl:Class ; rdfs:label "Broad distal phalanges of all fingers" ; rdfs:subClassOf obo:HP_0009836 . obo:HP_0009881 dcterms:creator ; oboInOwl:creation_date "2009-04-24T04:29:30Z" ; oboInOwl:hasDbXref "UMLS:C4024173" ; oboInOwl:hasExactSynonym "Absent distal phalanges of the hand", "Absent outermost hand bone", "Aplasia of outermost hand bone" ; oboInOwl:id "HP:0009881" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0009802, obo:HP_0009835 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009882 obo:IAO_0000115 "Short distance from the end of the finger to the most distal interphalangeal crease or the distal interphalangeal joint flexion point. That is, hypoplasia of one or more of the distal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-04-24T04:29:30Z" ; oboInOwl:hasAlternativeId "HP:0001198", "HP:0001202", "HP:0001221", "HP:0001229", "HP:0005669", "HP:0006075", "HP:0006076", "HP:0006132", "HP:0006199", "HP:0006223" ; oboInOwl:hasDbXref "UMLS:C1839829" ; oboInOwl:hasExactSynonym "Brachytelophalangy", "Distal phalangeal hypoplasia", "Hypoplasia of the distal phalanges", "Hypoplasia of the distal phalanges of the hand", "Hypoplasic terminal phalanges", "Hypoplastic distal phalanges", "Hypoplastic terminal phalanges", "Short distal phalanges", "Short outermost finger bone", "Terminal phalangeal hypoplasia of hand" ; oboInOwl:id "HP:0009882" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term differs from Partial absence of the finger because in that term, the phalanx must be missing, whereas in this term it may be small, but present. Distal phalangeal lengths can be assessed subjectively by comparing that digit segment to the rest of the digit, to other normal digits in that patient, or to typical patients of that age or build. Regarding the subjective definition, for individuals who do not have flexion creases, one may determine this by flexing the DIP joint and estimating the length of the terminal segment of the digit. Alternatively, one may be able to palpate the joint." ; rdfs:label "Short distal phalanx of finger" ; rdfs:subClassOf obo:HP_0009381, obo:HP_0009803, obo:HP_0009835 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009883 obo:IAO_0000115 "This term applies if one or more of the distal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-04-24T04:33:55Z" ; oboInOwl:hasAlternativeId "HP:0001228", "HP:0010007" ; oboInOwl:hasDbXref "UMLS:C1849343" ; oboInOwl:hasExactSynonym "Bifid terminal phalanges", "Duplication of the outermost bone of hand", "Notched outermost bone of hand", "Partial/complete duplication of the distal phalanges of the hand" ; oboInOwl:id "HP:0009883" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of hand" ; rdfs:subClassOf obo:HP_0009832, obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010001 obo:HP_0010004 ) ] ] . obo:HP_0009884 obo:IAO_0000115 "A reduction in diameter of the distal phalanx of finger towards the distal end." ; dcterms:creator ; oboInOwl:creation_date "2009-04-24T04:40:31Z" ; oboInOwl:hasAlternativeId "HP:0006052" ; oboInOwl:hasDbXref "UMLS:C1969237" ; oboInOwl:hasExactSynonym "Tapered distal phalanges", "Tapered distal phalanges of the hand", "Tapered outermost finger bone" ; oboInOwl:id "HP:0009884" ; a owl:Class ; rdfs:label "Tapered distal phalanges of finger" ; rdfs:subClassOf obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009885 oboInOwl:consider "HP:0001511" ; oboInOwl:id "HP:0009885" ; a owl:Class ; rdfs:label "obsolete Prenatal short stature" ; owl:deprecated true . obo:HP_0009886 obo:IAO_0000115 "Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T05:51:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:22486004", "SNOMEDCT_US:238736006", "UMLS:C0263485" ; oboInOwl:id "HP:0009886" ; a owl:Class ; rdfs:label "Trichorrhexis nodosa" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0009887 obo:IAO_0000115 "An abnormality of hair pigmentation (color)." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:00:53Z" ; oboInOwl:hasDbXref "UMLS:C4024172" ; oboInOwl:hasExactSynonym "Abnormality of hair color", "Abnormality of hair colour", "Abnormality of hair pigmentation" ; oboInOwl:id "HP:0009887" ; a owl:Class ; rdfs:label "Abnormality of hair pigmentation" ; rdfs:subClassOf obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009888 obo:IAO_0000115 "Abnormality of the growth of secondary sexual hair, which normally ensues during puberty. In males, secondary sexual hair usually comprises body hair, including underarm, abdominal, chest, and pubic hair. In females, secondary sexual hair usually comprises a lesser degree of body hair, most prominently underarm and pubic hair." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:18:33Z" ; oboInOwl:hasDbXref "UMLS:C4024171" ; oboInOwl:hasExactSynonym "Abnormality of secondary sexual hair" ; oboInOwl:id "HP:0009888" ; a owl:Class ; rdfs:label "Abnormality of secondary sexual hair" ; rdfs:subClassOf obo:HP_0001595 . obo:HP_0009889 obo:IAO_0000115 "Abnormally increased hair growth with a localized distribution." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:29:20Z" ; oboInOwl:hasDbXref "UMLS:C4024170" ; oboInOwl:hasExactSynonym "Localised abnormal hair growth", "Localised hirsutism", "Localized abnormal hair growth" ; oboInOwl:id "HP:0009889" ; a owl:Class ; rdfs:label "Localized hirsutism" ; rdfs:subClassOf obo:HP_0001007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000627 ] ) ] ] . obo:HP_0009890 obo:IAO_0000115 "Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD above the mean. Alternatively, an apparently increased distance between the hairline and the glabella." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:34:27Z" ; oboInOwl:hasDbXref "UMLS:C3276036" ; oboInOwl:hasExactSynonym "High frontal hairline" ; oboInOwl:id "HP:0009890" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature gives the appearance of a tall forehead, and may or may not include reduction of hair in the temporal areas. This can be distinguished from male pattern baldness as the hairline is the superior boundary of the muscular forehead, which can be actively wrinkled, in contrast to the scalp where no wrinkling can occur. In addition, texture of the skin of the scalp differs from the texture of the skin over the forehead." ; rdfs:label "High anterior hairline" ; rdfs:subClassOf obo:HP_0000599 . obo:HP_0009891 obo:IAO_0000115 "Flatness of the supraorbital portion of the frontal bones." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:50:09Z" ; oboInOwl:hasAlternativeId "HP:0004667", "HP:0004672", "HP:0005337" ; oboInOwl:hasDbXref "UMLS:C1861869", "UMLS:C4020777" ; oboInOwl:hasExactSynonym "Depressed supraorbital margins", "Depressed supraorbital ridge", "Flat supraorbital margins", "Flat supraorbital ridge", "Flattened bony protrusion above eyes", "Hypoplasia of supraorbital margins", "Hypoplasia of the supraorbital ridges", "Hypoplastic supraorbital ridges", "Shallow orbital ridges", "Shallow supraorbital ridge" ; oboInOwl:hasRelatedSynonym "Underdeveloped brows" ; oboInOwl:id "HP:0009891" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Underdeveloped supraorbital ridges" ; rdfs:subClassOf obo:HP_0100538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009892 obo:IAO_0000115 "Complete absence of any auricular structures." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T06:53:41Z" ; oboInOwl:hasDbXref "MSH:D065817", "SNOMEDCT_US:57436000", "UMLS:C0702139", "UMLS:C1408788" ; oboInOwl:hasRelatedSynonym "Absent ear", "Absent ears", "Congenital absence of external ear" ; oboInOwl:id "HP:0009892" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Complete absence of the auricle (external ear). The skin of the cheek passes smoothly over the aural area without definite elevation or depression." ; rdfs:label "Anotia" ; rdfs:subClassOf obo:HP_0008772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009893 obo:IAO_0000115 "The presence of telangiectasia of the ear." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:07:39Z" ; oboInOwl:hasDbXref "UMLS:C4024169" ; oboInOwl:id "HP:0009893" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Telangiectasia of the ear" ; rdfs:subClassOf obo:HP_0000377, obo:HP_0100585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009894 obo:IAO_0000115 "Increased thickness of the external ear." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:09:17Z" ; oboInOwl:hasDbXref "UMLS:C4024168" ; oboInOwl:hasExactSynonym "Thickened ears" ; oboInOwl:id "HP:0009894" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thickened ears" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009895 obo:IAO_0000115 "An abnormality of the crus of the helix, which is the horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:32:41Z" ; oboInOwl:hasDbXref "UMLS:C4021380" ; oboInOwl:hasExactSynonym "Abnormality of the crus of the ear" ; oboInOwl:id "HP:0009895" ; a owl:Class ; rdfs:label "Abnormality of the crus of the helix" ; rdfs:subClassOf obo:HP_0011039, obo:HP_3000022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009896 obo:IAO_0000115 "An abnormality of the antitragus, which is a small tubercle opposite to the tragus of the ear. The antitragus and the tragus are separated by the intertragic notch." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:13:21Z" ; oboInOwl:hasDbXref "UMLS:C4024167" ; oboInOwl:id "HP:0009896" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal antitragus morphology" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009897 obo:IAO_0000115 "An abnormal horizontal axis orientation of the crus of the helix. That is, the main axis of the crus of the helix is perpendicular to the medial longitudinal axis of the ear, instead of sloping inferoposteriorly." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:34:52Z" ; oboInOwl:hasDbXref "UMLS:C4021379" ; oboInOwl:hasExactSynonym "Helix, crus, horizontal", "Horizontal orientation of the crus of helix", "Horizontal orientation of the ear crus" ; oboInOwl:hasRelatedSynonym "Railroad track ears", "Railroad track sign" ; oboInOwl:id "HP:0009897" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The term 'railroad track sign' has been used to describe prominent horizontal crus of the helix in combination with prominent and parallel inferior crus of the antihelix. It is preferable to simply describe each component separately." ; rdfs:label "Horizontal crus of helix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0009898 obo:IAO_0000115 "Developmental hypoplasia of the crus of the helix. That is, flatter and/or shorter crus helix than average." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:36:43Z" ; oboInOwl:hasDbXref "UMLS:C4021378" ; oboInOwl:hasExactSynonym "Hypoplasia of the crus of the ear", "Underdeveloped crus of the ear" ; oboInOwl:id "HP:0009898" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Underdeveloped crus of the helix" ; rdfs:subClassOf obo:HP_0009895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009899 obo:IAO_0000115 "The presence of an abnormally prominent of the crus of the helix. That is, development of the crus helix to the same degree as an average antihelix stem or helix." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:38:06Z" ; oboInOwl:hasDbXref "UMLS:C4021377" ; oboInOwl:hasExactSynonym "Abnormal prominence of the crus of the ear", "Helix, crus, prominent", "Hyperplastic helix crus", "Hypertrophic helix crus" ; oboInOwl:id "HP:0009899" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent crus of helix" ; rdfs:subClassOf obo:HP_0009895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009900 obo:IAO_0000115 "A unilateral absence of sensory perception of sound." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:42:23Z" ; oboInOwl:hasDbXref "MSH:D046088", "SNOMEDCT_US:162342008", "UMLS:C2607947" ; oboInOwl:hasExactSynonym "Deafness in one ear", "Deafness, unilateral" ; oboInOwl:id "HP:0009900" ; a owl:Class ; rdfs:comment "Deafness affecting only one ear." ; rdfs:label "Unilateral deafness" ; rdfs:subClassOf obo:HP_0000365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0009901 obo:IAO_0000115 "Distortion of the course of the normal folds of the ear and the appearance of supernumerary crura and folds." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:50:28Z" ; oboInOwl:hasDbXref "UMLS:C4024166" ; oboInOwl:hasExactSynonym "Crumpled ear" ; oboInOwl:id "HP:0009901" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is distinct from Stahl ear and Shell ear, with which the term has sometimes been conflated. The appearance often changes markedly after birth." ; rdfs:label "Crumpled ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0009902 obo:IAO_0000115 "A notched form of the helix of the ear. That is, a defect in the continuity of the helix, which may occur at any point along its length." ; dcterms:creator ; oboInOwl:creation_date "2009-04-30T10:52:45Z" ; oboInOwl:hasDbXref "UMLS:C4021376" ; oboInOwl:hasExactSynonym "Notched helix", "Notching of the ear helix" ; oboInOwl:id "HP:0009902" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This may take the form of a sharp cleft or a less well-demarcated area. This should be distinguished from a Question-mark ear. If the defect or notch occurs at the junction of the superior and descending portions of the helix, it should be coded as Darwin notch of the helix." ; rdfs:label "Cleft helix" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001495 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009903 obo:IAO_0000115 "Presence of nodules in the conjunctiva of the eye." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T05:04:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:428477002", "UMLS:C1996949" ; oboInOwl:id "HP:0009903" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Conjunctival nodule" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0009904 obo:IAO_0000115 "Abnormally prominent ear helix." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T02:49:39Z" ; oboInOwl:hasDbXref "UMLS:C4020776", "UMLS:C4024165" ; oboInOwl:hasRelatedSynonym "Large helix" ; oboInOwl:id "HP:0009904" ; a owl:Class ; rdfs:label "Prominent ear helix" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009905 obo:IAO_0000115 "Decreased thickness of the helix of the ear." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T02:50:35Z" ; oboInOwl:hasDbXref "UMLS:C4024164" ; oboInOwl:id "HP:0009905" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thin ear helix" ; rdfs:subClassOf obo:HP_0011039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009906 obo:IAO_0000115 "Absence or underdevelopment of the ear lobes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T02:55:12Z" ; oboInOwl:hasDbXref "UMLS:C1851792" ; oboInOwl:hasExactSynonym "Absent/small ear lobes", "Absent/underdeveloped ear lobes" ; oboInOwl:id "HP:0009906" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the earlobes" ; rdfs:subClassOf obo:HP_0000363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001847 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009907 obo:IAO_0000115 "Attachment of the lobe to the side of the face at the lowest point of the lobe without curving upward." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T02:57:50Z" ; oboInOwl:hasDbXref "UMLS:C4021375" ; oboInOwl:hasExactSynonym "Adherent earlobe", "Attached earlobe" ; oboInOwl:id "HP:0009907" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The earlobe does not have a dependent portion." ; rdfs:label "Attached earlobe" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0009908 obo:IAO_0000115 "Sharply demarcated, typically linear and approximately horizontal, indentations in the outer surface of the ear lobe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:00:22Z" ; oboInOwl:hasAlternativeId "HP:0008604" ; oboInOwl:hasDbXref "UMLS:C1851897" ; oboInOwl:hasExactSynonym "Earlobe crease", "Transverse earlobe creases" ; oboInOwl:id "HP:0009908" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Shallow grooves or indentations are quite common, especially in large lobes. Ear lobe creases may arise postnatally. Posterior helical pits can be a related finding but should be assessed and coded separately." ; rdfs:label "Anterior creases of earlobe" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0009909 obo:IAO_0000115 "An abnormal orientation of the earlobes such that they point out- and upward. That is, the lateral surface of ear lobe faces superiorly." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:02:07Z" ; oboInOwl:hasAlternativeId "HP:0009764" ; oboInOwl:hasDbXref "UMLS:C1856117" ; oboInOwl:hasExactSynonym "Fleshy upturned lobules", "Lobe, uplifted", "Uplifted earlobe", "Upturned earlobe" ; oboInOwl:hasRelatedSynonym "Uplifted earlobes", "Upturned earlobes" ; oboInOwl:id "HP:0009909" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is characteristic of Mowat-Wilson syndrome." ; rdfs:label "Uplifted earlobe" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0009910 obo:IAO_0000115 "Absence of the middle ear ossicles, malleus, incus, and stapes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:26:53Z" ; oboInOwl:hasDbXref "UMLS:C4021374" ; oboInOwl:hasExactSynonym "Absent middle ear bones", "Absent middle ear ossicles" ; oboInOwl:id "HP:0009910" ; a owl:Class ; rdfs:label "Aplasia of the middle ear ossicles" ; rdfs:subClassOf obo:HP_0004452 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001686 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009911 obo:IAO_0000115 "Abnormality of the temporal bone of the skull, which is situated at the sides and base of the skull roughly underlying the region of the face known as the temple." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:33:17Z" ; oboInOwl:hasDbXref "UMLS:C4024163" ; oboInOwl:hasExactSynonym "Abnormality of the temporal bone" ; oboInOwl:id "HP:0009911" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal temporal bone morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001678 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009912 obo:IAO_0000115 "An abnormality of the tragus." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:39:56Z" ; oboInOwl:hasDbXref "UMLS:C4024162" ; oboInOwl:hasExactSynonym "Abnormality of the tragus" ; oboInOwl:id "HP:0009912" ; a owl:Class ; rdfs:comment "The tragus is the small pointed eminence of the external ear, situated in front of the concha, and projecting backward over the auditory canal." ; rdfs:label "Abnormal tragus morphology" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009913 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the tragus." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:43:12Z" ; oboInOwl:hasDbXref "UMLS:C4024161" ; oboInOwl:hasExactSynonym "Absent/small tragus", "Absent/underdeveloped tragus" ; oboInOwl:id "HP:0009913" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the tragus" ; rdfs:subClassOf obo:HP_0009912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009914 obo:IAO_0000115 "Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose." ; dcterms:creator ; oboInOwl:creation_date "2009-05-01T03:52:15Z" ; oboInOwl:hasDbXref "MSH:C562573", "SNOMEDCT_US:205798005", "UMLS:C0266667" ; oboInOwl:hasExactSynonym "Cyclops eye", "Single central eye" ; oboInOwl:id "HP:0009914" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cyclopia" ; rdfs:subClassOf obo:HP_0100886 . obo:HP_0009915 obo:IAO_0000115 "The presence of a size difference between the left and right cornea." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T05:06:20Z" ; oboInOwl:hasDbXref "UMLS:C4021373" ; oboInOwl:hasExactSynonym "Asymmetry of the corneas" ; oboInOwl:id "HP:0009915" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Corneal asymmetry" ; rdfs:subClassOf obo:HP_0001120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009916 obo:IAO_0000115 "Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T05:46:50Z" ; oboInOwl:hasDbXref "MSH:D015875", "SNOMEDCT_US:13045009", "UMLS:C0003079" ; oboInOwl:hasExactSynonym "Asymmetric pupil sizes", "Asymmetry of the pupils", "Unequal pupil dilatation", "Unequal pupil size" ; oboInOwl:id "HP:0009916" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Pathologic anisocoria can reflect an abnormality of the musculature of the iris or of the sympathetic or prasympathetic innervation of the iris." ; rdfs:label "Anisocoria" ; rdfs:subClassOf obo:HP_0000615 . obo:HP_0009917 obo:IAO_0000115 "The presence of remnants of a fetal membrane that persist as strands of tissue crossing the pupil." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T05:51:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95500008", "UMLS:C0344541" ; oboInOwl:id "HP:0009917" ; a owl:Class ; rdfs:comment "The tunica vasculosa lentis anterior (pupillary membrane) normally undergoes atrophy in the third trimester of pregnancy. If the membrane does not completely atrophy, then remnants of membranous structures can be observed to emrge from the iris." ; rdfs:label "Persistent pupillary membrane" ; rdfs:subClassOf obo:HP_0000615 . obo:HP_0009918 obo:IAO_0000115 "A malposition of the pupil owing to a developmental defect of the iris." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T06:01:01Z" ; oboInOwl:hasDbXref "MSH:C536185", "SNOMEDCT_US:193523008", "SNOMEDCT_US:392461003", "UMLS:C1271219" ; oboInOwl:hasExactSynonym "Corectopia", "Displaced pupil" ; oboInOwl:id "HP:0009918" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ectopia pupillae" ; rdfs:subClassOf obo:HP_0000615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009919 obo:IAO_0000115 "A tumor of the eye originating from cells of the retina." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T06:23:25Z" ; oboInOwl:hasBroadSynonym "Retina tumor", "Retina tumour" ; oboInOwl:hasDbXref "MSH:D012175", "MSH:D019572", "NCIT:C7541", "SNOMEDCT_US:127002001", "SNOMEDCT_US:19906005", "SNOMEDCT_US:370967009", "UMLS:C0035335", "UMLS:C0524801" ; oboInOwl:id "HP:0009919" ; a owl:Class ; rdfs:label "Retinoblastoma" ; rdfs:subClassOf obo:HP_0002898, obo:HP_0012777, obo:HP_0030063 . obo:HP_0009920 obo:IAO_0000115 "A dermal melanocytic hamartoma that presents as bluish hyperpigmentation on the face along the first or second branches of the trigeminal nerve. Nevus of Ota may involve the sclera." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T06:26:59Z" ; oboInOwl:hasDbXref "MSH:D009507", "SNOMEDCT_US:254817005", "SNOMEDCT_US:414929001", "UMLS:C0027961" ; oboInOwl:hasExactSynonym "Congenital melanosis bulbi", "Naevus fuscoceruleus ophthalmomaxillaris", "Nevus fuscoceruleus ophthalmomaxillaris", "Oculodermal melanocytosis" ; oboInOwl:id "HP:0009920" ; a owl:Class ; rdfs:label "Nevus of Ota" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0009921 obo:IAO_0000115 "A condition associated with a limitation of the horizontal ocular movement with retraction of the globe and narrowing of the palpebral fissure on adduction" ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T06:32:41Z" ; oboInOwl:hasAlternativeId "HP:0001109" ; oboInOwl:hasDbXref "MSH:D004370", "SNOMEDCT_US:60318001", "UMLS:C0013261", "UMLS:C1846464", "UMLS:C4072873" ; oboInOwl:hasExactSynonym "Limited eye motility from Duane anomaly", "Limited eye movement from Duane anomaly" ; oboInOwl:hasRelatedSynonym "Globe retraction and deviation on adduction" ; oboInOwl:id "HP:0009921" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Duane anomaly" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0009922 obo:IAO_0000115 "Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T06:43:07Z" ; oboInOwl:hasDbXref "UMLS:C4024160" ; oboInOwl:hasExactSynonym "Persistence of the hyaloid artery", "Persistent hyaloid artery" ; oboInOwl:id "HP:0009922" ; a owl:Class ; rdfs:label "Vascular remnant arising from the disc" ; rdfs:subClassOf obo:HP_0007968 . obo:HP_0009924 obo:IAO_0000115 "Underdevelopment or absence of the nose or parts thereof." ; dcterms:creator ; oboInOwl:creation_date "2009-05-05T06:44:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204519007", "SNOMEDCT_US:93278002", "UMLS:C0685684", "UMLS:C4024159", "UMLS:C4280392" ; oboInOwl:hasExactSynonym "Decreased nasal size", "Decreased size of nose" ; oboInOwl:hasNarrowSynonym "Hypoplasia of the nose", "Hypotrophic nose" ; oboInOwl:id "HP:0009924" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia involving the nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009926 obo:IAO_0000115 "Abnormally increased lacrimation, that is, excessive tearing (watering eye)." ; dcterms:creator ; oboInOwl:creation_date "2009-05-02T10:52:28Z" ; oboInOwl:hasAlternativeId "HP:0001486" ; oboInOwl:hasDbXref "MSH:D007766", "SNOMEDCT_US:193982009", "SNOMEDCT_US:418035005", "UMLS:C0152227" ; oboInOwl:hasExactSynonym "Increased lacrimation", "Increased tears", "Tearing", "Watery eyes" ; oboInOwl:id "HP:0009926" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Epiphora or tearing is the presence of a watering eye, which is a common complaint for referrals to oculoplastics clinics for evaluation. The etiology of tearing can be divided into two categories: reflex tearing and reduced tear outflow. Reflex tearing is usually secondary to dry eye, inflammation, allergy or other ocular surface disorders, whereas primary hypersecretion of the lacrimal glands is rare. Reduced tear outflow is due to eyelid malposition, tear pump dysfunction caused by eyelid laxity, or obstruction at any portion of the nasaolacrimal drainage system." ; rdfs:label "Epiphora" ; rdfs:subClassOf obo:HP_0000632 . obo:HP_0009927 obo:IAO_0000115 "Complete absence of all nasal structures." ; dcterms:creator ; oboInOwl:creation_date "2009-05-05T06:44:57Z" ; oboInOwl:hasDbXref "MSH:C537438", "SNOMEDCT_US:111317000", "UMLS:C0265740", "UMLS:C4280391" ; oboInOwl:hasExactSynonym "Absent nose", "Arrhinia", "Failure of development of nose", "Nasal underdevelopment", "Underdevelopment of nose" ; oboInOwl:hasNarrowSynonym "Missing nose" ; oboInOwl:id "HP:0009927" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplasia of the nose" ; rdfs:subClassOf obo:HP_0009924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000617 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009928 obo:IAO_0000115 "Increase in bulk of the ala nasi." ; dcterms:creator ; oboInOwl:creation_date "2009-05-05T06:47:43Z" ; oboInOwl:hasDbXref "UMLS:C1844809" ; oboInOwl:hasExactSynonym "Ala nasi, thick", "Thickening of the alae nasi" ; oboInOwl:id "HP:0009928" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thick nasal alae" ; rdfs:subClassOf obo:HP_0000429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009929 obo:IAO_0000115 "A structural abnormality of the columella." ; dcterms:creator ; oboInOwl:creation_date "2009-05-05T06:51:28Z" ; oboInOwl:hasDbXref "UMLS:C4024158" ; oboInOwl:hasExactSynonym "Abnormality of the columella", "Anomaly of the columella" ; oboInOwl:hasNarrowSynonym "Deformity of the columella", "Malformation of the columella" ; oboInOwl:id "HP:0009929" ; a owl:Class ; rdfs:comment "The columella is the fleshy external end of the nasal septum." ; rdfs:label "Abnormal columella morphology" ; rdfs:subClassOf obo:HP_0010938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008341 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009930 obo:IAO_0000115 "Asymmetry or size difference between the left and right nostril." ; dcterms:creator ; oboInOwl:creation_date "2009-05-05T07:06:20Z" ; oboInOwl:hasDbXref "UMLS:C4024157" ; oboInOwl:hasExactSynonym "Asymmetry of nostrils", "Crooked nostrils", "Unequal nostril shape", "Unequal nostril size", "Uneven nostril shape", "Uneven nostril size" ; oboInOwl:id "HP:0009930" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the nares" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009931 obo:IAO_0000115 "Increased aperture of the nostril." ; oboInOwl:creation_date "2009-05-10T10:30:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:399353008", "UMLS:C0426440" ; oboInOwl:hasExactSynonym "Broad nostril", "Dilated nares", "Dilated nostril", "Enlarged nares", "Enlarged nostril", "Increased diameter of nares", "Increased diameter of nostril", "Increased width of nares", "Large nares", "Naris, broad", "Naris, enlarged", "Wide nares", "Wide nostril" ; oboInOwl:id "HP:0009931" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The nostrils or nares are typically symmetric, wide openings. They should be assessed with the face at rest to avoid the effect of flared alae nasi that occurs with distress. Note that the nares change with age, from rounded in infancy to elongated at a later age." ; rdfs:label "Enlarged naris" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009932 obo:IAO_0000115 "The presence of only a single nostril." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:33:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95266003", "UMLS:C0685682" ; oboInOwl:hasExactSynonym "Mono nostril", "One nostril", "Single nare", "Single nostril" ; oboInOwl:id "HP:0009932" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The single opening may occur in the midline or it can occur on one side, that is, it can be symmetric or asymmetric. Although the columella is invariably absent, this is implicit and does not need to be separately specified." ; rdfs:label "Single naris" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005928 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009933 obo:IAO_0000115 "Slender, slit-like aperture of the nostril." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:35:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249336003", "SNOMEDCT_US:249339005", "UMLS:C0426436", "UMLS:C0426439", "UMLS:C1849366", "UMLS:C4280390" ; oboInOwl:hasExactSynonym "Naris, narrow", "Naris, slit-like", "Narrow nares", "Narrow nostrils", "Slit-like nostrils", "Small nostrils", "Thin nares", "Thin nostrils" ; oboInOwl:hasRelatedSynonym "Collapsed nostrils" ; oboInOwl:id "HP:0009933" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow naris" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009934 obo:IAO_0000115 "The presence of more than two nostrils." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:37:41Z" ; oboInOwl:hasDbXref "UMLS:C4021372" ; oboInOwl:hasExactSynonym "Accessory nares", "Accessory nostril", "Extra nostril", "Supernumerary nares", "Supernumerary nostrils" ; oboInOwl:id "HP:0009934" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Supernumerary naris" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009935 obo:IAO_0000115 "Absence or underdevelopment of the nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:40:21Z" ; oboInOwl:hasDbXref "UMLS:C4024156" ; oboInOwl:hasExactSynonym "Ageneis of nasal septum", "Underdevelopment of nasal septum" ; oboInOwl:hasNarrowSynonym "Failure of development of nasal septum" ; oboInOwl:id "HP:0009935" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the nasal septum" ; rdfs:subClassOf obo:HP_0000419, obo:HP_0009924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009936 obo:IAO_0000115 "Abnormally narrow nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:46:40Z" ; oboInOwl:hasDbXref "UMLS:C4024155" ; oboInOwl:hasExactSynonym "Decreased width of nasal septum", "Narrow nasal septum", "Narrow septum of nose", "Thin nasal septum", "Thin septum of nose" ; oboInOwl:id "HP:0009936" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow nasal septum" ; rdfs:subClassOf obo:HP_0000419 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009937 obo:IAO_0000115 "Excess facial hair." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T10:58:49Z" ; oboInOwl:hasBroadSynonym "Excessive face hair" ; oboInOwl:hasDbXref "UMLS:C1850041", "UMLS:C2128203" ; oboInOwl:id "HP:0009937" ; a owl:Class ; rdfs:label "Facial hirsutism" ; rdfs:subClassOf obo:HP_0009889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010171 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009938 obo:IAO_0000115 "Lack or loss of the soft tissues between the zygomata and mandible." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T11:17:18Z" ; oboInOwl:hasDbXref "UMLS:C4024154" ; oboInOwl:hasExactSynonym "Depressed cheeks", "Hollow cheeks", "Sunken cheeks" ; oboInOwl:id "HP:0009938" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sunken cheeks" ; rdfs:subClassOf obo:HP_0004426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000585 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009939 obo:IAO_0000115 "Absence of the mandible." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T11:27:14Z" ; oboInOwl:hasBroadSynonym "Agnathia" ; oboInOwl:hasDbXref "SNOMEDCT_US:91896009", "SNOMEDCT_US:91922000", "UMLS:C0685775", "UMLS:C0685776", "UMLS:C4021371" ; oboInOwl:hasExactSynonym "Absence of lower jaw", "Absence of lower jaw bone", "Absence of mandible", "Absent mandible", "Agenesis of the mandible", "Aplasia of the lower jaw bone", "Failure of development of lower jaw", "Failure of development of mandible", "Missing lower jaw" ; oboInOwl:hasNarrowSynonym "Absence of lower jaw bones" ; oboInOwl:id "HP:0009939" ; a owl:Class ; rdfs:label "Mandibular aplasia" ; rdfs:subClassOf obo:HP_0009118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009940 obo:IAO_0000115 "Lack of symmetry between the left and right mandible." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T11:28:02Z" ; oboInOwl:hasBroadSynonym "Tilted mandible" ; oboInOwl:hasDbXref "SNOMEDCT_US:235082006", "UMLS:C0399518", "UMLS:C4082201" ; oboInOwl:hasExactSynonym "Asymmetry of lower jaw", "Canted lower jaw", "Canted mandible", "Crooked lower jaw", "Deviation of lower jaw", "Deviation of mandible", "Lower jaw shifted to one side", "Tilted lower jaw", "Uneven lower jaw", "Uneven mandible" ; oboInOwl:hasRelatedSynonym "Deviation of the lower jaw", "Deviation of the mandible" ; oboInOwl:id "HP:0009940" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the mandible" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009941 obo:IAO_0000115 "The presence of an asymmetric mouth." ; dcterms:creator ; oboInOwl:creation_date "2009-05-10T11:30:31Z" ; oboInOwl:hasDbXref "UMLS:C4024153" ; oboInOwl:hasExactSynonym "Asymmetry of the mouth", "Canted mouth", "Crooked mouth", "Tilted mouth", "Uneven mouth" ; oboInOwl:hasRelatedSynonym "Asymmetry of oral cavity" ; oboInOwl:id "HP:0009941" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the mouth" ; rdfs:subClassOf obo:HP_0011338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009942 obo:IAO_0000115 "Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T12:51:02Z" ; oboInOwl:hasAlternativeId "HP:0009661" ; oboInOwl:hasDbXref "UMLS:C4021370" ; oboInOwl:hasExactSynonym "Complete/partial duplication of phalanges of the thumb", "Duplicated thumbs", "Duplication of phalanx of thumb" ; oboInOwl:hasRelatedSynonym "Duplicated thumb" ; oboInOwl:id "HP:0009942" ; a owl:Class ; rdfs:label "Duplication of thumb phalanx" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009943 obo:HP_0009944 ) ] ] . obo:HP_0009943 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the thumb. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T12:51:35Z" ; oboInOwl:hasAlternativeId "HP:0002801", "HP:0004067" ; oboInOwl:hasDbXref "UMLS:C3554724" ; oboInOwl:hasExactSynonym "Complete duplication of the phalanges of the thumb", "Complete duplication of thumb bones", "Digitalization of thumb", "Digitalization of thumbs" ; oboInOwl:id "HP:0009943" ; a owl:Class ; rdfs:label "Complete duplication of thumb phalanx" ; rdfs:subClassOf obo:HP_0009942, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009944 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T12:51:57Z" ; oboInOwl:hasAlternativeId "HP:0001244", "HP:0004070" ; oboInOwl:hasDbXref "UMLS:C4082168" ; oboInOwl:hasExactSynonym "Bifid thumb", "Notching of thumb phalanges", "Partial duplication of the phalanges of the thumb", "Partial duplication of the thumb bones" ; oboInOwl:id "HP:0009944" ; a owl:Class ; rdfs:label "Partial duplication of thumb phalanx" ; rdfs:subClassOf obo:HP_0009942, obo:HP_0009999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009945 obo:IAO_0000115 "This term applies if one or more of the phalanges of the 2nd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T01:00:37Z" ; oboInOwl:hasDbXref "UMLS:C4021369" ; oboInOwl:hasExactSynonym "Duplication of the bones of index finger", "Partial/complete duplication of phalanges of the 2nd finger" ; oboInOwl:id "HP:0009945" ; a owl:Class ; rdfs:label "Duplication of phalanx of 2nd finger" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0009946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009956 obo:HP_0009957 ) ] ] . obo:HP_0009946 dcterms:creator ; oboInOwl:creation_date "2009-05-15T01:01:48Z" ; oboInOwl:hasDbXref "UMLS:C4024152" ; oboInOwl:hasExactSynonym "Extra index finger" ; oboInOwl:id "HP:0009946" ; a owl:Class ; rdfs:label "Polydactyly affecting the 2nd finger" ; rdfs:subClassOf obo:HP_0004100, obo:HP_0006159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009947 obo:IAO_0000115 "Partial or complete duplication of the second proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T01:58:58Z" ; oboInOwl:hasDbXref "UMLS:C4021368" ; oboInOwl:hasExactSynonym "Duplication of the proximal bone of the index finger", "Partial/complete duplication of the proximal phalanx of the 2nd finger" ; oboInOwl:id "HP:0009947" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009544, obo:HP_0009945, obo:HP_0010006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009954 obo:HP_0009955 ) ] ] . obo:HP_0009948 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T01:58:58Z" ; oboInOwl:hasAlternativeId "HP:0004144" ; oboInOwl:hasDbXref "UMLS:C4021367" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the distal phalanx of the 2nd finger", "Partial/complete duplication of the outermost bone of the index finger" ; oboInOwl:id "HP:0009948" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0009883, obo:HP_0009945 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009950 obo:HP_0009951 ) ] ] . obo:HP_0009949 obo:IAO_0000115 "Partial or complete duplication of the middle phalanx of index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T01:58:58Z" ; oboInOwl:hasDbXref "UMLS:C4021366" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the middle bone of the index finger", "Partial/complete duplication of the middle phalanx of the 2nd finger" ; oboInOwl:id "HP:0009949" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0009945, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009952 obo:HP_0009953 ) ] ] . obo:HP_0009950 obo:IAO_0000115 "Complete duplication of the distal phalanx of index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:03:28Z" ; oboInOwl:hasDbXref "UMLS:C4024151" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bone of the index finger" ; oboInOwl:id "HP:0009950" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009948, obo:HP_0009957, obo:HP_0010001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009951 obo:IAO_0000115 "Partial duplication of the distal phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:03:28Z" ; oboInOwl:hasDbXref "UMLS:C4021365" ; oboInOwl:hasExactSynonym "Bifid terminal phalanx of the 2nd finger", "Notched outermost bone of the index finger", "Partial duplication of the outermost bone of the 2nd finger" ; oboInOwl:id "HP:0009951" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009948, obo:HP_0009956, obo:HP_0010004 . obo:HP_0009952 obo:IAO_0000115 "Complete duplication of the middle phalanx of index finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:05:27Z" ; oboInOwl:hasDbXref "UMLS:C4024150" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the index finger" ; oboInOwl:id "HP:0009952" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009949, obo:HP_0009957, obo:HP_0010002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009953 obo:IAO_0000115 "Partial duplication of the middle phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:05:27Z" ; oboInOwl:hasDbXref "UMLS:C4024149" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the index finger" ; oboInOwl:id "HP:0009953" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009949, obo:HP_0009956, obo:HP_0010005 . obo:HP_0009954 obo:IAO_0000115 "Complete duplication of the second proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:06:11Z" ; oboInOwl:hasDbXref "UMLS:C4024148" ; oboInOwl:hasExactSynonym "Complete duplication of the proximal bone of the index finger" ; oboInOwl:id "HP:0009954" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009947, obo:HP_0009957, obo:HP_0010000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004328 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009955 obo:IAO_0000115 "Partial duplication of the second proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:06:11Z" ; oboInOwl:hasDbXref "UMLS:C4024147" ; oboInOwl:hasExactSynonym "Partial duplication of the proximal bones of the index finger" ; oboInOwl:id "HP:0009955" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0009947, obo:HP_0009956, obo:HP_0010003 . obo:HP_0009956 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 2nd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:07:41Z" ; oboInOwl:hasDbXref "UMLS:C4024146" ; oboInOwl:hasExactSynonym "Partial duplication of the bones of the index finger" ; oboInOwl:id "HP:0009956" ; a owl:Class ; rdfs:label "Partial duplication of the phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009945, obo:HP_0009999 . obo:HP_0009957 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the 2nd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-15T02:08:02Z" ; oboInOwl:hasDbXref "UMLS:C4024145" ; oboInOwl:hasExactSynonym "Complete duplication of the bones of the index finger" ; oboInOwl:id "HP:0009957" ; a owl:Class ; rdfs:label "Complete duplication of the phalanges of the 2nd finger" ; rdfs:subClassOf obo:HP_0009945, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003636 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009958 dcterms:creator ; oboInOwl:creation_date "2009-05-26T09:54:29Z" ; oboInOwl:hasDbXref "UMLS:C4024144" ; oboInOwl:hasExactSynonym "Extra middle finger" ; oboInOwl:id "HP:0009958" ; a owl:Class ; rdfs:label "Polydactyly affecting the 3rd finger" ; rdfs:subClassOf obo:HP_0004150, obo:HP_0006159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003623 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009959 obo:IAO_0000115 "This term applies if one or more of the phalanges of the 3rd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T09:54:51Z" ; oboInOwl:hasDbXref "UMLS:C4021364" ; oboInOwl:hasExactSynonym "Duplication of middle finger bone", "Partial/complete duplication of phalanges of the 3rd finger" ; oboInOwl:id "HP:0009959" ; a owl:Class ; rdfs:label "Duplication of phalanx of 3rd finger" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0009958 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009960 obo:HP_0009961 ) ] ] . obo:HP_0009960 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the 3rd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4024143" ; oboInOwl:hasExactSynonym "Complete duplication of middle finger bones" ; oboInOwl:id "HP:0009960" ; a owl:Class ; rdfs:label "Complete duplication of the phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009959, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009961 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 3rd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4024142" ; oboInOwl:hasExactSynonym "Partial duplication of middle finger bones" ; oboInOwl:id "HP:0009961" ; a owl:Class ; rdfs:label "Partial duplication of the phalanges of the 3rd finger" ; rdfs:subClassOf obo:HP_0009959, obo:HP_0009999 . obo:HP_0009962 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of middle finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4021363" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the distal phalanx of the 3rd finger", "Partial/complete duplication of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009962" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0009883, obo:HP_0009959 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009965 obo:HP_0009968 ) ] ] . obo:HP_0009963 obo:IAO_0000115 "Partial or complete duplication of the middle phalanx of middle finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:46:36Z" ; oboInOwl:hasAlternativeId "HP:0004157", "HP:0004174" ; oboInOwl:hasDbXref "UMLS:C4021362" ; oboInOwl:hasExactSynonym "Duplication of the middle bone of the middle finger", "Partial/complete duplication of the middle phalanx of the 3rd finger" ; oboInOwl:id "HP:0009963" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0009959, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009966 obo:HP_0009969 ) ] ] . obo:HP_0009964 obo:IAO_0000115 "Partial or complete duplication of the third proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4021361" ; oboInOwl:hasExactSynonym "Duplication of the proximal bone of the middle finger", "Partial/complete duplication of the proximal phalanx of the 3rd finger" ; oboInOwl:id "HP:0009964" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009358, obo:HP_0009959, obo:HP_0010006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009967 obo:HP_0009970 ) ] ] . obo:HP_0009965 obo:IAO_0000115 "Complete duplication of the distal phalanx of middle finger" ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:35Z" ; oboInOwl:hasDbXref "UMLS:C4024141" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bone of the 3rd finger" ; oboInOwl:id "HP:0009965" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009960, obo:HP_0009962, obo:HP_0010001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009966 obo:IAO_0000115 "Complete duplication of the middle phalanx of middle finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:35Z" ; oboInOwl:hasDbXref "UMLS:C4024140" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the middle finger" ; oboInOwl:id "HP:0009966" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009960, obo:HP_0009963, obo:HP_0010002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009967 obo:IAO_0000115 "Complete duplication of the third proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:35Z" ; oboInOwl:hasDbXref "UMLS:C4024139" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost bone of the 3rd finger" ; oboInOwl:id "HP:0009967" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009960, obo:HP_0009964, obo:HP_0010000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009968 obo:IAO_0000115 "Partial duplication of the distal phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:59Z" ; oboInOwl:hasDbXref "UMLS:C4021360" ; oboInOwl:hasExactSynonym "Bifid terminal phalanx of the 3rd finger", "Notched outermost bone of the middle finger", "Partial duplication of the outermost bone of the middle finger" ; oboInOwl:id "HP:0009968" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009961, obo:HP_0009962, obo:HP_0010004 . obo:HP_0009969 obo:IAO_0000115 "Partial duplication of the middle phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:59Z" ; oboInOwl:hasDbXref "UMLS:C4024138" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the 3rd finger" ; oboInOwl:id "HP:0009969" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009961, obo:HP_0009963, obo:HP_0010005 . obo:HP_0009970 obo:IAO_0000115 "Partial duplication of the third proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T12:49:59Z" ; oboInOwl:hasDbXref "UMLS:C4024137" ; oboInOwl:hasExactSynonym "Partial duplication of the proximal bone of the middle finger" ; oboInOwl:id "HP:0009970" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0009961, obo:HP_0009964, obo:HP_0010003 . obo:HP_0009971 dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:19:06Z" ; oboInOwl:hasDbXref "UMLS:C4024136" ; oboInOwl:hasExactSynonym "Extra ring finger" ; oboInOwl:id "HP:0009971" ; a owl:Class ; rdfs:label "Polydactyly affecting the 4th finger" ; rdfs:subClassOf obo:HP_0004188, obo:HP_0006159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003624 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009972 obo:IAO_0000115 "This term applies if one or more of the phalanges of the 4th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:19:28Z" ; oboInOwl:hasDbXref "UMLS:C4021359" ; oboInOwl:hasExactSynonym "Duplication of bones of the ring finger", "Partial/complete duplication of phalanges of the 4th finger" ; oboInOwl:id "HP:0009972" ; a owl:Class ; rdfs:label "Duplication of phalanx of 4th finger" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0009971 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009973 obo:HP_0009974 ) ] ] . obo:HP_0009973 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the 4th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4024135" ; oboInOwl:hasExactSynonym "Complete duplication of the bones of the ring finger" ; oboInOwl:id "HP:0009973" ; a owl:Class ; rdfs:label "Complete duplication of the phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009972, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009974 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 4th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4024134" ; oboInOwl:hasExactSynonym "Partial duplication of the bones of the ring finger" ; oboInOwl:id "HP:0009974" ; a owl:Class ; rdfs:label "Partial duplication of the phalanges of the 4th finger" ; rdfs:subClassOf obo:HP_0009972, obo:HP_0009999 . obo:HP_0009975 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4021358" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the distal phalanx of the 4th finger", "Partial/complete duplication of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009975" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0009883, obo:HP_0009972 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009978 obo:HP_0009981 ) ] ] . obo:HP_0009976 obo:IAO_0000115 "Partial or complete duplication of the middle phalanx of ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4021357" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the middle bone of the ring finger", "Partial/complete duplication of the middle phalanx of the 4th finger" ; oboInOwl:id "HP:0009976" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0009972, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009979 obo:HP_0009982 ) ] ] . obo:HP_0009977 obo:IAO_0000115 "Partial or complete duplication of the fourth proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4021356" ; oboInOwl:hasExactSynonym "Duplication of the proximal bone of the ring finger", "Partial/complete duplication of the proximal phalanx of the 4th finger" ; oboInOwl:id "HP:0009977" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009284, obo:HP_0009972, obo:HP_0010006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009950 obo:HP_0009983 ) ] ] . obo:HP_0009978 obo:IAO_0000115 "Complete duplication of the distal phalanx of ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:23Z" ; oboInOwl:hasDbXref "UMLS:C4024133" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009978" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009973, obo:HP_0009975, obo:HP_0010001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009979 obo:IAO_0000115 "Complete duplication of the middle phalanx of ring finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:23Z" ; oboInOwl:hasDbXref "UMLS:C4024132" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the ring finger" ; oboInOwl:id "HP:0009979" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009973, obo:HP_0009976, obo:HP_0010002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009980 obo:IAO_0000115 "Complete duplication of the fourth proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:23Z" ; oboInOwl:hasDbXref "UMLS:C4024131" ; oboInOwl:hasExactSynonym "Complete duplication of the proximal bone of the ring finger" ; oboInOwl:id "HP:0009980" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009973, obo:HP_0009977, obo:HP_0010000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004330 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009981 obo:IAO_0000115 "Partial duplication of the distal phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:37Z" ; oboInOwl:hasDbXref "UMLS:C4021355" ; oboInOwl:hasExactSynonym "Bifid terminal phalanx of the 4th finger", "Notched outermost bone of the ring finger", "Partial duplication of the outermost bone of the ring finger" ; oboInOwl:id "HP:0009981" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009974, obo:HP_0009975, obo:HP_0010004 . obo:HP_0009982 obo:IAO_0000115 "Partial duplication of the middle phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:37Z" ; oboInOwl:hasDbXref "UMLS:C4024130" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the ring finger" ; oboInOwl:id "HP:0009982" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009974, obo:HP_0009976, obo:HP_0010005 . obo:HP_0009983 obo:IAO_0000115 "Partial duplication of the fourth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:20:37Z" ; oboInOwl:hasDbXref "UMLS:C4024129" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bone of the ring finger" ; oboInOwl:id "HP:0009983" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0009974, obo:HP_0009977, obo:HP_0010003 . obo:HP_0009985 obo:IAO_0000115 "This term applies if one or more of the phalanges of the 5th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:23:38Z" ; oboInOwl:hasDbXref "UMLS:C4021354" ; oboInOwl:hasExactSynonym "Partial/complete duplication of little finger bone", "Partial/complete duplication of phalanges of the 5th finger", "Partial/complete duplication of pinkie finger bone", "Partial/complete duplication of pinky finger bone" ; oboInOwl:id "HP:0009985" ; a owl:Class ; rdfs:label "Duplication of phalanx of 5th finger" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009986 obo:HP_0009987 ) ] ] . obo:HP_0009986 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the 5th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:20Z" ; oboInOwl:hasDbXref "UMLS:C4024128" ; oboInOwl:hasExactSynonym "Complete duplication of the little finger bone", "Complete duplication of the pinkie finger bone", "Complete duplication of the pinky finger bone" ; oboInOwl:id "HP:0009986" ; a owl:Class ; rdfs:label "Complete duplication of the phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0009985, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009987 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 5th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:20Z" ; oboInOwl:hasDbXref "UMLS:C4024127" ; oboInOwl:hasExactSynonym "Partial duplication of the little finger bone", "Partial duplication of the pinkie finger bone", "Partial duplication of the pinky finger bone" ; oboInOwl:id "HP:0009987" ; a owl:Class ; rdfs:label "Partial duplication of the phalanges of the 5th finger" ; rdfs:subClassOf obo:HP_0009985, obo:HP_0009999 . obo:HP_0009988 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of little finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:20Z" ; oboInOwl:hasDbXref "UMLS:C4021353" ; oboInOwl:hasExactSynonym "Duplication of the outermost little finger bone", "Duplication of the outermost pinkie finger bone", "Duplication of the outermost pinky finger bone", "Partial/complete duplication of the distal phalanx of the 5th finger" ; oboInOwl:id "HP:0009988" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0009883, obo:HP_0009985 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009991 obo:HP_0009994 ) ] ] . obo:HP_0009989 obo:IAO_0000115 "Partial or complete duplication of the fifth middle phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:20Z" ; oboInOwl:hasDbXref "UMLS:C4021352" ; oboInOwl:hasExactSynonym "Duplication of the middle little finger bone", "Duplication of the middle pinkie finger bone", "Duplication of the middle pinky finger bone", "Partial/complete duplication of the middle phalanx of the 5th finger" ; oboInOwl:id "HP:0009989" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0009985, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009992 obo:HP_0009995 ) ] ] . obo:HP_0009990 obo:IAO_0000115 "Partial or complete duplication of the fifth proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:20Z" ; oboInOwl:hasDbXref "UMLS:C4021351" ; oboInOwl:hasExactSynonym "Duplication of the innermost little finger bone", "Duplication of the innermost pinkie finger bone", "Duplication of the innermost pinky finger bone", "Partial/complete duplication of the proximal phalanx of the 5th finger" ; oboInOwl:id "HP:0009990" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009150, obo:HP_0009985, obo:HP_0010006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009993 obo:HP_0009996 ) ] ] . obo:HP_0009991 obo:IAO_0000115 "Complete duplication of the distal phalanx of little finger." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:33Z" ; oboInOwl:hasDbXref "UMLS:C4024126" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost little finger bone", "Complete duplication of the outermost pinkie finger bone", "Complete duplication of the outermost pinky finger bone" ; oboInOwl:id "HP:0009991" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009986, obo:HP_0009988, obo:HP_0010001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009992 obo:IAO_0000115 "Complete duplication of the fifth middle phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:33Z" ; oboInOwl:hasDbXref "UMLS:C4024125" ; oboInOwl:hasExactSynonym "Complete duplication of the middle little finger bone", "Complete duplication of the middle pinkie finger bone", "Complete duplication of the middle pinky finger bone" ; oboInOwl:id "HP:0009992" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009986, obo:HP_0009989, obo:HP_0010002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009993 obo:IAO_0000115 "Complete duplication of the fifth proximal phalanx of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:33Z" ; oboInOwl:hasDbXref "UMLS:C4024124" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost little finger bone", "Complete duplication of the innermost pinkie finger bone", "Complete duplication of the innermost pinky finger bone" ; oboInOwl:id "HP:0009993" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009986, obo:HP_0009990, obo:HP_0010000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009994 obo:IAO_0000115 "Partial duplication of the distal phalanx of little finger, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:47Z" ; oboInOwl:hasDbXref "UMLS:C4021350" ; oboInOwl:hasExactSynonym "Bifid terminal phalanx of the 5th finger", "Notched outermost pinky finger bone", "Partial duplication of outermost little finger bone", "Partial duplication of outermost pinkie finger bone", "Partial duplication of outermost pinky finger bone" ; oboInOwl:id "HP:0009994" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009987, obo:HP_0009988, obo:HP_0010004 . obo:HP_0009995 obo:IAO_0000115 "Partial duplication of the fifth middle phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:47Z" ; oboInOwl:hasDbXref "UMLS:C4024123" ; oboInOwl:hasExactSynonym "Partial duplication of the middle little finger bone", "Partial duplication of the middle pinkie finger bone", "Partial duplication of the middle pinky finger bone" ; oboInOwl:id "HP:0009995" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009987, obo:HP_0009989, obo:HP_0010005 . obo:HP_0009996 obo:IAO_0000115 "Partial or complete duplication of the fifth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:24:47Z" ; oboInOwl:hasDbXref "UMLS:C4024122" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost little finger bone", "Partial duplication of the innermost pinkie finger bone", "Partial duplication of the innermost pinky finger bone" ; oboInOwl:id "HP:0009996" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0009987, obo:HP_0009990, obo:HP_0010003 . obo:HP_0009997 obo:IAO_0000115 "This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:28:25Z" ; oboInOwl:hasAlternativeId "HP:0009143" ; oboInOwl:hasDbXref "UMLS:C4021349" ; oboInOwl:hasExactSynonym "Duplication of finger bones" ; oboInOwl:id "HP:0009997" ; a owl:Class ; rdfs:label "Duplication of phalanx of hand" ; rdfs:subClassOf obo:HP_0004275, obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0009998 obo:HP_0009999 ) ] ] . obo:HP_0009998 obo:IAO_0000115 "A complete duplication affecting one or more of the phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:30:16Z" ; oboInOwl:hasDbXref "UMLS:C4024121" ; oboInOwl:hasExactSynonym "Complete duplication of hand bones" ; oboInOwl:id "HP:0009998" ; a owl:Class ; rdfs:label "Complete duplication of phalanx of hand" ; rdfs:subClassOf obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0009999 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T02:30:35Z" ; oboInOwl:hasDbXref "UMLS:C4024120" ; oboInOwl:hasExactSynonym "Partial duplication of hand bones" ; oboInOwl:id "HP:0009999" ; a owl:Class ; rdfs:label "Partial duplication of the phalanx of hand" ; rdfs:subClassOf obo:HP_0009997 . obo:HP_0010000 obo:IAO_0000115 "A complete duplication affecting one or more of the proximal phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:02Z" ; oboInOwl:hasDbXref "UMLS:C4024119" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost bones of the hand" ; oboInOwl:id "HP:0010000" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009998, obo:HP_0010006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010001 obo:IAO_0000115 "A complete duplication affecting one or more of the distal phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:02Z" ; oboInOwl:hasDbXref "UMLS:C4024118" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bones of the hand" ; oboInOwl:id "HP:0010001" ; a owl:Class ; rdfs:comment "As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, is actually a different entity called a pseudoepiphysis (see corresponding terms), sometimes also referred to as hyperphalangism." ; rdfs:label "Complete duplication of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009883, obo:HP_0009998 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010002 obo:IAO_0000115 "A complete duplication affecting one or more of the middle phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a pseudoepiphysis (see corresponding terms) sometimes also referred to as hyperphalangism." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:02Z" ; oboInOwl:hasDbXref "UMLS:C4024117" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bones of the hand" ; oboInOwl:id "HP:0010002" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009998, obo:HP_0010008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010003 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the proximal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:29Z" ; oboInOwl:hasDbXref "UMLS:C4024116" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bones of the hand" ; oboInOwl:id "HP:0010003" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009999, obo:HP_0010006 . obo:HP_0010004 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the distal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:29Z" ; oboInOwl:hasAlternativeId "HP:0006196" ; oboInOwl:hasDbXref "UMLS:C4021348" ; oboInOwl:hasExactSynonym "Bifid terminal phalanges of the hand", "Partial duplication of the outermost bone of the hand" ; oboInOwl:id "HP:0010004" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009883, obo:HP_0009999 . obo:HP_0010005 obo:IAO_0000115 "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the middle phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T03:55:29Z" ; oboInOwl:hasDbXref "UMLS:C4024115" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bones of hand" ; oboInOwl:id "HP:0010005" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0009999, obo:HP_0010008 . obo:HP_0010006 obo:IAO_0000115 "This term applies if one or more of the proximal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T05:29:46Z" ; oboInOwl:hasDbXref "UMLS:C4021347" ; oboInOwl:hasExactSynonym "Duplication of the innermost bones of hand", "Partial/complete duplication of the proximal phalanges of the hand" ; oboInOwl:id "HP:0010006" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of hand" ; rdfs:subClassOf obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010000 obo:HP_0010003 ) ] ] . obo:HP_0010008 obo:IAO_0000115 "This term applies if one or more of the middle phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." ; dcterms:creator ; oboInOwl:creation_date "2009-05-26T05:29:46Z" ; oboInOwl:hasDbXref "UMLS:C4021346" ; oboInOwl:hasExactSynonym "Duplication of the middle bones of hand", "Partial/complete duplication of the middle phalanges of the hand" ; oboInOwl:id "HP:0010008" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of hand" ; rdfs:subClassOf obo:HP_0009833, obo:HP_0009834, obo:HP_0009997 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010002 obo:HP_0010005 ) ] ] . obo:HP_0010009 obo:IAO_0000115 "A structural anomaly of the first metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:35:21Z" ; oboInOwl:hasDbXref "UMLS:C4024114" ; oboInOwl:hasExactSynonym "Abnormality of the 1st long bone of hand", "Abnormality of the 1st metacarpal" ; oboInOwl:id "HP:0010009" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits." ; rdfs:label "Abnormal 1st metacarpal morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010010 obo:IAO_0000115 "Any abnormality of the second metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:35:21Z" ; oboInOwl:hasDbXref "UMLS:C4024113" ; oboInOwl:hasExactSynonym "Abnormality of the 2nd long bone of hand", "Abnormality of the 2nd metacarpal" ; oboInOwl:id "HP:0010010" ; a owl:Class ; rdfs:label "Abnormal 2nd metacarpal morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010011 obo:IAO_0000115 "Any abnormality of the third metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:35:21Z" ; oboInOwl:hasDbXref "UMLS:C4024112" ; oboInOwl:hasExactSynonym "Abnormality of the 3rd long bone of hand", "Abnormality of the 3rd metacarpal" ; oboInOwl:id "HP:0010011" ; a owl:Class ; rdfs:label "Abnormal 3rd metacarpal morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010012 obo:IAO_0000115 "Any abnormality of the fourth metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:35:21Z" ; oboInOwl:hasDbXref "UMLS:C4024111" ; oboInOwl:hasExactSynonym "Abnormality of the 4th long bone of hand", "Abnormality of the 4th metacarpal" ; oboInOwl:id "HP:0010012" ; a owl:Class ; rdfs:label "Abnormal 4th metacarpal morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010013 obo:IAO_0000115 "Any abnormality of the fifth metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:35:21Z" ; oboInOwl:hasDbXref "UMLS:C4024110" ; oboInOwl:hasExactSynonym "Abnormality of the 5th long bone of hand", "Abnormality of the 5th metacarpal" ; oboInOwl:id "HP:0010013" ; a owl:Class ; rdfs:label "Abnormal 5th metacarpal morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010014 obo:IAO_0000115 "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits). The epiphysis of the first metacarpal is localized at the proximal end (as seen in the proximal phalanges of the other digits), whereas the epiphyses of the other metacarpal bones are located at the distal end. This term applies if the epiphysis of the 1st metacarpal is in any way abnormal, referring to age and gender depending norms, as seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T03:43:11Z" ; oboInOwl:hasDbXref "UMLS:C4024109" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010014" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0005913, obo:HP_0010009, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004391 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010015 dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024108" ; oboInOwl:hasExactSynonym "Absent end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010015" ; a owl:Class ; rdfs:label "Absent epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009196, obo:HP_0010014, obo:HP_0010268 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004391 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010016 obo:IAO_0000115 "An epiphysis that curves around from its transverse orientation to a longitudinal one from proximal to distal along one side of the phalanx, thus resembling the letter 'C' and forming a bracket around the diaphysis. This results in a so called delta phalanx characterized by a triangular or trapezoidal shaped bone with a C-shaped epiphyseal plate." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024107" ; oboInOwl:hasExactSynonym "Bracket shaped end part of 1st long bone of hand" ; oboInOwl:id "HP:0010016" ; a owl:Class ; rdfs:label "Bracket epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0010014, obo:HP_0010269, obo:HP_0200050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010017 obo:IAO_0000115 "A cone-shaped appearance of the epiphysis of the 1st metacarpal, producing a 'ball-in-a-socket' appearance." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024106" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010017" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0006059, obo:HP_0010014, obo:HP_0010270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010018 obo:IAO_0000115 "Abnormally large size of the epiphyses of the 1st metacarpal with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024105" ; oboInOwl:hasExactSynonym "Enlarged end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010018" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0006134, obo:HP_0010014, obo:HP_0010271 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010019 obo:IAO_0000115 "Epiphysis of the 1st metacarpal having multiple bony fragments." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024104" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010019" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009189, obo:HP_0010014, obo:HP_0010272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010020 obo:IAO_0000115 "Uneven radiographic opacity of the epiphysis of the 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024103" ; oboInOwl:hasExactSynonym "Irregular end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010020" ; a owl:Class ; rdfs:label "Irregular epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009190, obo:HP_0010014, obo:HP_0010273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010021 obo:IAO_0000115 "The epiphysis of the 1st metacarpal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024102" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010021" ; a owl:Class ; rdfs:label "Ivory epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009191, obo:HP_0010014, obo:HP_0010274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010022 obo:IAO_0000115 "The epiphysis of the first metacarpal is localized at the proximal end of the metacarpal bone although an accessory epiphysis may be located at the distal end of the metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024101" ; oboInOwl:id "HP:0010022" ; a owl:Class ; rdfs:comment "This feature can be seen for example in Holt-Oram Syndrome." ; rdfs:label "Pseudoepiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009193, obo:HP_0010014, obo:HP_0010275 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004391 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010023 obo:IAO_0000115 "Abnormally small size of the epiphysis of the 1st metacarpal with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024100" ; oboInOwl:hasExactSynonym "Small end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010023" ; a owl:Class ; rdfs:label "Small epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009194, obo:HP_0010014, obo:HP_0010276 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010024 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the first metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4021345" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the first long bone of hand", "Stippling of the epiphysis of the 1st metacarpal" ; oboInOwl:id "HP:0010024" ; a owl:Class ; rdfs:label "Epiphyseal stippling of the first metacarpal" ; rdfs:subClassOf obo:HP_0009195, obo:HP_0010014, obo:HP_0010277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010025 dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:02:50Z" ; oboInOwl:hasDbXref "UMLS:C4024099" ; oboInOwl:hasExactSynonym "Triangular end part of the 1st long bone of hand" ; oboInOwl:id "HP:0010025" ; a owl:Class ; rdfs:label "Triangular epiphysis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009171, obo:HP_0009696, obo:HP_0010014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004391 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010026 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits)." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024098" ; oboInOwl:hasExactSynonym "Absent/small 1st long bone of hand", "Absent/underdeveloped 1st long bone of hand" ; oboInOwl:id "HP:0010026" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0005914, obo:HP_0009658, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010027 obo:IAO_0000115 "Increased width of the 1st metacarpal. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024097" ; oboInOwl:hasExactSynonym "Wide 1st long bone of hand" ; oboInOwl:id "HP:0010027" ; a owl:Class ; rdfs:label "Broad 1st metacarpal" ; rdfs:subClassOf obo:HP_0001230, obo:HP_0009852, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010028 obo:IAO_0000115 "The presence of short and wide 1st metacarpal which tapers distally (\"bullet shaped\")." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024096" ; oboInOwl:hasExactSynonym "Bullet-shaped 1st long bone of hand" ; oboInOwl:id "HP:0010028" ; a owl:Class ; rdfs:label "Bullet-shaped 1st metacarpal" ; rdfs:subClassOf obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010029 obo:IAO_0000115 "A deviation from the normal straight shape of the first metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024095" ; oboInOwl:hasExactSynonym "Curved 1st long bone of hand" ; oboInOwl:id "HP:0010029" ; a owl:Class ; rdfs:label "Curved 1st metacarpal" ; rdfs:subClassOf obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010030 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024094" ; oboInOwl:id "HP:0010030" ; a owl:Class ; rdfs:comment "Osteolytic lesions are visible on radiography as demarcated areas of radiolucency ('darkness')." ; rdfs:label "Osteolytic defects of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0001504, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010031 obo:IAO_0000115 "Uneven increase in bone density within the 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024093" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in 1st long bone of hand" ; oboInOwl:id "HP:0010031" ; a owl:Class ; rdfs:label "Patchy sclerosis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0010009, obo:HP_0100914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010033 obo:IAO_0000115 "This term applies to a triangular shaped 1st metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:30Z" ; oboInOwl:hasDbXref "UMLS:C4024092" ; oboInOwl:hasExactSynonym "Triangular shaped 1st long bone of hand" ; oboInOwl:id "HP:0010033" ; a owl:Class ; rdfs:comment "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx (in this case metacarpal, see explanation above)." ; rdfs:label "Triangular shaped 1st metacarpal" ; rdfs:subClassOf obo:HP_0010009 . obo:HP_0010034 obo:IAO_0000115 "A developmental defect characterized by reduced length of the first metacarpal (long bone) of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:24:50Z" ; oboInOwl:hasAlternativeId "HP:0001190", "HP:0001499", "HP:0005898", "HP:0006141" ; oboInOwl:hasDbXref "UMLS:C1849311" ; oboInOwl:hasExactSynonym "First metacarpal hypoplasia", "First metacarpals hypoplastic", "Hypoplastic 1st metacarpal", "Short first metacarpal", "Short first metacarpals", "Shortened 1st long bone of hand" ; oboInOwl:id "HP:0010034" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; rdfs:label "Short 1st metacarpal" ; rdfs:subClassOf obo:HP_0009660, obo:HP_0010026, obo:HP_0010049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010035 obo:IAO_0000115 "Absent first metacarpal (long bone) of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:25:14Z" ; oboInOwl:hasAlternativeId "HP:0006027" ; oboInOwl:hasDbXref "UMLS:C1838610" ; oboInOwl:hasExactSynonym "Absent 1st long bone of hand", "Absent first metacarpal" ; oboInOwl:id "HP:0010035" ; a owl:Class ; rdfs:comment "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; rdfs:label "Aplasia of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0009659, obo:HP_0010026, obo:HP_0010048, obo:HP_0010242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010036 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the 2nd metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:34:44Z" ; oboInOwl:hasDbXref "UMLS:C4024091" ; oboInOwl:hasExactSynonym "Absent/small 2nd long bone of hand", "Absent/underdeveloped 2nd long bone of hand" ; oboInOwl:id "HP:0010036" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 2nd metacarpal" ; rdfs:subClassOf obo:HP_0005914, obo:HP_0010010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010037 obo:IAO_0000115 "Absence of the second long bone of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:35:04Z" ; oboInOwl:hasDbXref "UMLS:C4024090" ; oboInOwl:hasExactSynonym "Absent 2nd long bone of hand" ; oboInOwl:id "HP:0010037" ; a owl:Class ; rdfs:label "Aplasia of the 2nd metacarpal" ; rdfs:subClassOf obo:HP_0010036, obo:HP_0010048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010038 obo:IAO_0000115 "Short second metacarpal bone because of developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:35:04Z" ; oboInOwl:hasAlternativeId "HP:0006231" ; oboInOwl:hasDbXref "UMLS:C1969397", "UMLS:C4020774" ; oboInOwl:hasExactSynonym "Rudimentary 2nd metacarpal", "Shortened 2nd long bone of hand" ; oboInOwl:hasRelatedSynonym "Hypoplastic 2nd metacarpal" ; oboInOwl:id "HP:0010038" ; a owl:Class ; rdfs:label "Short 2nd metacarpal" ; rdfs:subClassOf obo:HP_0010036, obo:HP_0010049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010039 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the 3rd metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:35:51Z" ; oboInOwl:hasDbXref "UMLS:C4024089" ; oboInOwl:hasExactSynonym "Absent/small 3rd long bone of hand", "Absent/underdeveloped 3rd long bone of hand" ; oboInOwl:id "HP:0010039" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0005914, obo:HP_0010011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010040 obo:IAO_0000115 "Absence of the third long bone of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:36:08Z" ; oboInOwl:hasDbXref "UMLS:C4024088" ; oboInOwl:hasExactSynonym "Absent 3rd long bone of hand" ; oboInOwl:id "HP:0010040" ; a owl:Class ; rdfs:label "Aplasia of the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0010039, obo:HP_0010048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010041 obo:IAO_0000115 "Short third metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:36:08Z" ; oboInOwl:hasAlternativeId "HP:0005624", "HP:0006074", "HP:0006120" ; oboInOwl:hasDbXref "UMLS:C1850631" ; oboInOwl:hasExactSynonym "Hypoplastic 3rd metacarpal", "Short third metacarpals", "Shortened 3rd long bone of hand", "Small 3rd metacarpals" ; oboInOwl:id "HP:0010041" ; a owl:Class ; rdfs:label "Short 3rd metacarpal" ; rdfs:subClassOf obo:HP_0010039, obo:HP_0010049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010042 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the 4th metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:36:49Z" ; oboInOwl:hasDbXref "UMLS:C4024087" ; oboInOwl:hasExactSynonym "Absent/small 4th long bone of hand", "Absent/underdeveloped 4th long bone of hand" ; oboInOwl:id "HP:0010042" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 4th metacarpal" ; rdfs:subClassOf obo:HP_0005914, obo:HP_0010012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010043 obo:IAO_0000115 "Absence of the fourth long bone of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:37:00Z" ; oboInOwl:hasDbXref "UMLS:C4024086" ; oboInOwl:hasExactSynonym "Absent 4th long bone of hand" ; oboInOwl:id "HP:0010043" ; a owl:Class ; rdfs:label "Aplasia of the 4th metacarpal" ; rdfs:subClassOf obo:HP_0010042, obo:HP_0010048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010044 obo:IAO_0000115 "Short fourth metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:37:00Z" ; oboInOwl:hasAlternativeId "HP:0005094" ; oboInOwl:hasDbXref "UMLS:C1840309" ; oboInOwl:hasExactSynonym "Hypoplastic fourth metacarpal", "Short 4th metacarpals", "Short fourth metacarpals", "Shortened 4th long bone of hand" ; oboInOwl:id "HP:0010044" ; a owl:Class ; rdfs:label "Short 4th metacarpal" ; rdfs:subClassOf obo:HP_0010042, obo:HP_0010049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010045 obo:IAO_0000115 "Aplasia or Hypoplasia affecting the 5th metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:37:31Z" ; oboInOwl:hasDbXref "UMLS:C4024085" ; oboInOwl:hasExactSynonym "Absent/small 5th long bone of hand", "Absent/underdeveloped 5th long bone of hand" ; oboInOwl:id "HP:0010045" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 5th metacarpal" ; rdfs:subClassOf obo:HP_0005914, obo:HP_0010013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010046 obo:IAO_0000115 "Absence of the fifth long bone of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:37:44Z" ; oboInOwl:hasAlternativeId "HP:0006103" ; oboInOwl:hasDbXref "UMLS:C1867929" ; oboInOwl:hasExactSynonym "Absent 5th long bone of hand", "Absent 5th metacarpal" ; oboInOwl:id "HP:0010046" ; a owl:Class ; rdfs:label "Aplasia of the 5th metacarpal" ; rdfs:subClassOf obo:HP_0010045, obo:HP_0010048 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010047 obo:IAO_0000115 "Short fifth metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:37:44Z" ; oboInOwl:hasAlternativeId "HP:0005737", "HP:0006004", "HP:0006222" ; oboInOwl:hasDbXref "UMLS:C1861388" ; oboInOwl:hasExactSynonym "Fifth metacarpal hypoplasia", "Hypoplastic 5th metacarpal", "Short fifth metacarpal", "Short fifth metacarpals", "Shortened 5th long bone of hand" ; oboInOwl:id "HP:0010047" ; a owl:Class ; rdfs:label "Short 5th metacarpal" ; rdfs:subClassOf obo:HP_0010045, obo:HP_0010049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010048 obo:IAO_0000115 "Developmental defect associated with absence of one or more metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:40:58Z" ; oboInOwl:hasAlternativeId "HP:0005911" ; oboInOwl:hasDbXref "UMLS:C1846473" ; oboInOwl:hasExactSynonym "Absent long bone of hand", "Absent metacarpal", "Absent metacarpals" ; oboInOwl:id "HP:0010048" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Aplasia of metacarpal bones" ; rdfs:subClassOf obo:HP_0005914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010049 obo:IAO_0000115 "Diminished length of one or more metacarpal bones in relation to the others of the same hand or to the contralateral metacarpal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-27T04:40:58Z" ; oboInOwl:hasAlternativeId "HP:0001164", "HP:0005695", "HP:0005717", "HP:0005909", "HP:0006047", "HP:0006183", "HP:0006186" ; oboInOwl:hasDbXref "UMLS:C1837084" ; oboInOwl:hasExactSynonym "Brachymetacarpalia", "Hypoplastic metacarpal", "Metacarpal hypoplasia", "Short metacarpals", "Shortened long bone of hand", "Shortened long bones of hand", "Shortened metacarpals", "Shortening of metacarpals" ; oboInOwl:hasRelatedSynonym "Short metacarpal bones" ; oboInOwl:id "HP:0010049" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Short metacarpals can involve any of the metacarpal bones, and the affected ray should be specified. The assessment of isolated short metacarpal can be made by viewing the dorsum of the hand when clenched. Note that if metacarpals F2-5 are affected, the correct term is Short palm." ; rdfs:label "Short metacarpal" ; rdfs:subClassOf obo:HP_0003026, obo:HP_0005914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010051 obo:IAO_0000115 "Displacement of the big toe from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T11:36:44Z" ; oboInOwl:hasAlternativeId "HP:0004700" ; oboInOwl:hasDbXref "UMLS:C4021344" ; oboInOwl:hasExactSynonym "Displacement of big toe", "Displacement of the hallux" ; oboInOwl:id "HP:0010051" ; a owl:Class ; rdfs:label "Deviation of the hallux" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010052 obo:IAO_0000115 "An abnormal shape or form of the proximal phalanx of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T11:47:46Z" ; oboInOwl:hasDbXref "UMLS:C4024084" ; oboInOwl:hasExactSynonym "Abnormal innermost big toe bone", "Abnormality of the proximal phalanx of the hallux" ; oboInOwl:id "HP:0010052" ; a owl:Class ; rdfs:comment "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the big toe is embryologically equivalent to the middle phalanges of the other digits, whereas the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." ; rdfs:label "Abnormal morphology of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010053 dcterms:creator ; oboInOwl:creation_date "2009-05-29T11:49:11Z" ; oboInOwl:hasDbXref "UMLS:C4024083" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of the big toe" ; oboInOwl:id "HP:0010053" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010054 obo:IAO_0000115 "An anomaly of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T11:49:54Z" ; oboInOwl:hasDbXref "UMLS:C4024082" ; oboInOwl:hasExactSynonym "Abnormality of the 1st long bone of foot" ; oboInOwl:id "HP:0010054" ; a owl:Class ; rdfs:comment "In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities of the first metatarsal." ; rdfs:label "Abnormality of the first metatarsal bone" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010055 obo:IAO_0000115 "Visible increase in width of the hallux without an increase in the dorso-ventral dimension." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T11:56:24Z" ; oboInOwl:hasAlternativeId "HP:0001834", "HP:0003094", "HP:0004710", "HP:0005883" ; oboInOwl:hasDbXref "UMLS:C1867131" ; oboInOwl:hasExactSynonym "Abnormally broad great toes", "Broad big toe", "Broad great toe", "Broad great toes", "Broad halluces", "Wide big toe" ; oboInOwl:id "HP:0010055" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that girth may be increased in a broad hallux, but this must be distinguished from Macrodactyly because there the length is also increased. This assessment may be difficult when the hallux is short." ; rdfs:label "Broad hallux" ; rdfs:subClassOf obo:HP_0001837, obo:HP_0001844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010056 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:00:08Z" ; oboInOwl:hasDbXref "UMLS:C4024081" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the big toe bone" ; oboInOwl:id "HP:0010056" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0010160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010057 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:00:08Z" ; oboInOwl:hasDbXref "UMLS:C4024080" ; oboInOwl:hasExactSynonym "Abnormal big toe bones", "Abnormality of the phalanges of the hallux" ; oboInOwl:id "HP:0010057" ; a owl:Class ; rdfs:label "Abnormal hallux phalanx morphology" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010058 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4024079" ; oboInOwl:hasExactSynonym "Absent/small big toe bone", "Absent/underdeveloped big toe bone" ; oboInOwl:id "HP:0010058" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the hallux" ; rdfs:subClassOf obo:HP_0008362, obo:HP_0010057, obo:HP_0010173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010059 obo:IAO_0000115 "An increase in width in one or more phalanges of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4021343" ; oboInOwl:hasExactSynonym "Broad bone of big toe", "Broad phalanges of the hallux", "Wide bone of big toe" ; oboInOwl:id "HP:0010059" ; a owl:Class ; rdfs:label "Broad hallux phalanx" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010060 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4021342" ; oboInOwl:hasExactSynonym "Bullet-shaped bone of big toe", "Bullet-shaped phalanges of the hallux" ; oboInOwl:id "HP:0010060" ; a owl:Class ; rdfs:label "Bullet-shaped hallux phalanx" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010175 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010061 obo:IAO_0000115 "A deviation from the normal straight form of one or more phalanges of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4021341" ; oboInOwl:hasExactSynonym "Curve bones of big toe", "Curved phalanges of the hallux" ; oboInOwl:id "HP:0010061" ; a owl:Class ; rdfs:label "Curved hallux phalanx" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010062 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4024078" ; oboInOwl:id "HP:0010062" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010063 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more phalanges of the big toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4021340" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the hallux", "Uneven increase in bone density in big toe bone" ; oboInOwl:id "HP:0010063" ; a owl:Class ; rdfs:label "Patchy sclerosis of hallux phalanx" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010178, obo:HP_0100930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010064 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasAlternativeId "HP:0004687" ; oboInOwl:hasDbXref "UMLS:C1836216" ; oboInOwl:hasExactSynonym "Fused big toe bones", "hallucal symphalangism" ; oboInOwl:id "HP:0010064" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010179, obo:HP_0100235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010065 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasDbXref "UMLS:C4024077" ; oboInOwl:hasExactSynonym "Triangular shaped bones of big toe" ; oboInOwl:id "HP:0010065" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010066 obo:IAO_0000115 "Partial or complete duplication of one or more phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:10:46Z" ; oboInOwl:hasAlternativeId "HP:0001784", "HP:0005785", "HP:0005851" ; oboInOwl:hasDbXref "UMLS:C1860164", "UMLS:C4020691" ; oboInOwl:hasExactSynonym "Duplicated hallux", "Duplication of big toe bone", "Duplication of great toes", "Duplication of phalanx of big toe", "Hallucal duplication" ; oboInOwl:hasNarrowSynonym "Partial/complete duplication of the phalanges of the hallux" ; oboInOwl:id "HP:0010066" ; a owl:Class ; rdfs:label "Duplication of phalanx of hallux" ; rdfs:subClassOf obo:HP_0010057, obo:HP_0010181 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010100 obo:HP_0010101 ) ] ] . obo:HP_0010067 obo:IAO_0000115 "Absence or underdevelopment of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024076" ; oboInOwl:hasExactSynonym "Absent/small 1st long bone of foot", "Absent/underdeveloped 1st long bone of foot" ; oboInOwl:id "HP:0010067" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010068 obo:IAO_0000115 "Increased side-to-side width of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasAlternativeId "HP:0004709", "HP:0008085", "HP:0008139" ; oboInOwl:hasDbXref "UMLS:C1855899" ; oboInOwl:hasExactSynonym "Broad 1st metatarsal", "Enlarged first metatarsal", "Wide 1st long bone of foot" ; oboInOwl:id "HP:0010068" ; a owl:Class ; rdfs:label "Broad first metatarsal" ; rdfs:subClassOf obo:HP_0001783, obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010069 obo:IAO_0000115 "An abnormal morphology of the firstmetatarsal bone, which is short and wide and tapers distally, and lacks the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024075" ; oboInOwl:hasExactSynonym "Bullet-shaped 1st long bone of foot" ; oboInOwl:id "HP:0010069" ; a owl:Class ; rdfs:label "Bullet-shaped 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010070 obo:IAO_0000115 "A deviation from the normal straight shape of a proximal phalanx of the 1st metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024074" ; oboInOwl:hasExactSynonym "Curved 1st long bone of foot" ; oboInOwl:id "HP:0010070" ; a owl:Class ; rdfs:label "Curved 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010071 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the first metatarsal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024073" ; oboInOwl:id "HP:0010071" ; a owl:Class ; rdfs:label "Osteolytic defects of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0001473, obo:HP_0010054, obo:HP_0010062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003650 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010072 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024072" ; oboInOwl:hasExactSynonym "Uneven increase in bone density of the 1st long bone of foot" ; oboInOwl:id "HP:0010072" ; a owl:Class ; rdfs:label "Patchy sclerosis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054, obo:HP_0010063, obo:HP_0010208, obo:HP_0100945 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003650 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010073 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024071" ; oboInOwl:hasExactSynonym "Fusion involving the 1st long bone of foot" ; oboInOwl:id "HP:0010073" ; a owl:Class ; rdfs:label "Synostosis involving the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010074 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4024070" ; oboInOwl:hasExactSynonym "Triangular shaped 1st long bone of foot" ; oboInOwl:id "HP:0010074" ; a owl:Class ; rdfs:label "Triangular shaped 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054, obo:HP_0010065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010075 obo:IAO_0000115 "A developmental defect consisting in the duplication of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C1851855" ; oboInOwl:hasExactSynonym "Duplicated 1st long bone of foot", "Duplicated first metatarsals" ; oboInOwl:id "HP:0010075" ; a owl:Class ; rdfs:label "Duplication of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0001449, obo:HP_0010054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010098 obo:HP_0010099 ) ] ] . obo:HP_0010076 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024069" ; oboInOwl:hasExactSynonym "Absent/small outermost big toe bone", "Absent/underdeveloped outermost big toe bone" ; oboInOwl:id "HP:0010076" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010058, obo:HP_0010185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010077 obo:IAO_0000115 "An increase in width of the distal phalanx of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024068" ; oboInOwl:hasExactSynonym "Broad outermost bone of big toe", "Wide outermost bone of big toe" ; oboInOwl:id "HP:0010077" ; a owl:Class ; rdfs:label "Broad distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010059, obo:HP_0010186 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010078 obo:IAO_0000115 "An abnormal morphology of the distal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024067" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of big toe" ; oboInOwl:id "HP:0010078" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010060, obo:HP_0010187 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010079 obo:IAO_0000115 "A deviation from the normal straight form of the distal phalanx of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024066" ; oboInOwl:hasExactSynonym "Curved outermost bone of big toe" ; oboInOwl:id "HP:0010079" ; a owl:Class ; rdfs:label "Curved distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010061, obo:HP_0010188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010080 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024065" ; oboInOwl:id "HP:0010080" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010062, obo:HP_0010189 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010081 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024064" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of big toe" ; oboInOwl:id "HP:0010081" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010063, obo:HP_0010190, obo:HP_0100944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010082 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024063" ; oboInOwl:hasExactSynonym "Fused outermost bone of big toe" ; oboInOwl:id "HP:0010082" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0001859, obo:HP_0010053, obo:HP_0010091, obo:HP_0010191 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010083 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4024062" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the big toe" ; oboInOwl:id "HP:0010083" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010065, obo:HP_0010192 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010084 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C4021339" ; oboInOwl:hasExactSynonym "Duplication of the outermost bone of big toe", "Partial/complete duplication of the distal phalanx of the hallux" ; oboInOwl:id "HP:0010084" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0010066, obo:HP_0010193 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010096 obo:HP_0010097 ) ] ] . obo:HP_0010085 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024061" ; oboInOwl:hasExactSynonym "Absent/small innermost big toe bone", "Absent/underdeveloped innermost big toe bone" ; oboInOwl:id "HP:0010085" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010058, obo:HP_0010194 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010086 obo:IAO_0000115 "Increased width of proximal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4021338" ; oboInOwl:hasExactSynonym "Broad innermost bone of the big toe", "Broad proximal phalanx of the big toe" ; oboInOwl:id "HP:0010086" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010059, obo:HP_0010204 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010087 obo:IAO_0000115 "An abnormal morphology of the proximal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024060" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost bone of the big toe" ; oboInOwl:id "HP:0010087" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010060, obo:HP_0010205 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010088 obo:IAO_0000115 "A deviation from the normal straight form of the proximal phalanx of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024059" ; oboInOwl:hasExactSynonym "Curved innermost bone of the big toe" ; oboInOwl:id "HP:0010088" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010061, obo:HP_0010206 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010089 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024058" ; oboInOwl:id "HP:0010089" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010062, obo:HP_0010198 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010090 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024057" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the big toe" ; oboInOwl:id "HP:0010090" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010063, obo:HP_0010199, obo:HP_0100943 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010091 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024056" ; oboInOwl:hasExactSynonym "Fused innermost bone of big toe" ; oboInOwl:id "HP:0010091" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010064, obo:HP_0010200 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010092 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024055" ; oboInOwl:hasExactSynonym "Triangular shaped innermost bone of big toe" ; oboInOwl:id "HP:0010092" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010065, obo:HP_0010201 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010093 obo:IAO_0000115 "Partial or complete duplication of the proximal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4024054" ; oboInOwl:hasExactSynonym "Duplication of the innermost bone of big toe" ; oboInOwl:id "HP:0010093" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0010066, obo:HP_0010202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010094 obo:HP_0010095 ) ] ] . obo:HP_0010094 obo:IAO_0000115 "Complete duplication of the proximal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:18:59Z" ; oboInOwl:hasDbXref "UMLS:C4024053" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost bone of big toe" ; oboInOwl:id "HP:0010094" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010093, obo:HP_0010100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010095 obo:IAO_0000115 "Partial duplication of the proximal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:18:59Z" ; oboInOwl:hasDbXref "UMLS:C4024052" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bone of big toe" ; oboInOwl:id "HP:0010095" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010093, obo:HP_0010101 . obo:HP_0010096 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:19:30Z" ; oboInOwl:hasDbXref "UMLS:C4024051" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bone of the big toe" ; oboInOwl:id "HP:0010096" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010084, obo:HP_0010100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010097 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:19:30Z" ; oboInOwl:hasAlternativeId "HP:0008091" ; oboInOwl:hasDbXref "UMLS:C4021337" ; oboInOwl:hasExactSynonym "Bifid distal phalanx of hallux", "Notched outermost bone of big toe", "Partial duplication of the outermost bone of big toe" ; oboInOwl:id "HP:0010097" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010084, obo:HP_0010101 . obo:HP_0010098 obo:IAO_0000115 "A developmental defect consisting in the complete duplication of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:20:12Z" ; oboInOwl:hasAlternativeId "HP:0008121" ; oboInOwl:hasDbXref "UMLS:C4024050" ; oboInOwl:hasExactSynonym "Complete duplication of the 1st long bone of foot" ; oboInOwl:id "HP:0010098" ; a owl:Class ; rdfs:label "Complete duplication of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010075 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010099 obo:IAO_0000115 "A developmental defect consisting in the duplication of part of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:20:12Z" ; oboInOwl:hasDbXref "UMLS:C4024049" ; oboInOwl:hasExactSynonym "Partial duplication of the 1st long bone of foot" ; oboInOwl:id "HP:0010099" ; a owl:Class ; rdfs:label "Partial duplication of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010075, obo:HP_0010101 . obo:HP_0010100 obo:IAO_0000115 "Complete duplication of one or more phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:22:12Z" ; oboInOwl:hasDbXref "UMLS:C4021336" ; oboInOwl:hasExactSynonym "Complete duplication of big toe bones", "Complete duplication of the phalanges of the hallux" ; oboInOwl:id "HP:0010100" ; a owl:Class ; rdfs:label "Complete duplication of hallux phalanx" ; rdfs:subClassOf obo:HP_0010066 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010101 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:22:12Z" ; oboInOwl:hasAlternativeId "HP:0004678" ; oboInOwl:hasDbXref "UMLS:C1855005" ; oboInOwl:hasExactSynonym "Partial duplication of big toe", "partial duplication of hallux" ; oboInOwl:id "HP:0010101" ; a owl:Class ; rdfs:label "Partial duplication of the phalanges of the hallux" ; rdfs:subClassOf obo:HP_0010066 . obo:HP_0010102 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:41:37Z" ; oboInOwl:hasDbXref "UMLS:C4024048" ; oboInOwl:hasExactSynonym "Absent outermost bone of big toe" ; oboInOwl:id "HP:0010102" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010076, obo:HP_0010110, obo:HP_0010645 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010103 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the distal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:41:37Z" ; oboInOwl:hasDbXref "UMLS:C4021335" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the hallux", "Small distal phalanx of big toe", "Small distal phalanx of hallux", "Small outermost bone of big toe" ; oboInOwl:id "HP:0010103" ; a owl:Class ; rdfs:label "Short distal phalanx of hallux" ; rdfs:subClassOf obo:HP_0010076, obo:HP_0010111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010104 obo:IAO_0000115 "A developmental defect characterized by the absence of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:42:09Z" ; oboInOwl:hasAlternativeId "HP:0006124" ; oboInOwl:hasDbXref "UMLS:C1863382" ; oboInOwl:hasExactSynonym "Absent 1st long bone of foot", "Absent 1st metatarsal", "Aplasia of the 1st metatarsal" ; oboInOwl:id "HP:0010104" ; a owl:Class ; rdfs:label "Absent first metatarsal" ; rdfs:subClassOf obo:HP_0010067, obo:HP_0010744 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010105 obo:IAO_0000115 "Short first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:42:09Z" ; oboInOwl:hasAlternativeId "HP:0004680" ; oboInOwl:hasDbXref "UMLS:C1841688" ; oboInOwl:hasExactSynonym "First metatarsal hypoplasia", "First metatarsals hypoplastic", "Short 1st long bone of foot" ; oboInOwl:id "HP:0010105" ; a owl:Class ; rdfs:label "Short first metatarsal" ; rdfs:subClassOf obo:HP_0010054, obo:HP_0010743 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010106 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:43:40Z" ; oboInOwl:hasDbXref "UMLS:C4024047" ; oboInOwl:hasExactSynonym "Absent innermost bone of big toe" ; oboInOwl:id "HP:0010106" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010085, obo:HP_0010110, obo:HP_0100388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010107 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the proximal phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:43:40Z" ; oboInOwl:hasAlternativeId "HP:0008101", "HP:0008129" ; oboInOwl:hasDbXref "UMLS:C1862159" ; oboInOwl:hasExactSynonym "Hypoplastic proximal phalanx of the hallux", "Short innermost big toe bone", "Short proximal phalanges of halluces", "Short proximal phalanx of halluces", "Small proximal phalanx of big toe", "Small proximal phalanx of hallux" ; oboInOwl:id "HP:0010107" ; a owl:Class ; rdfs:label "Short proximal phalanx of hallux" ; rdfs:subClassOf obo:HP_0010085, obo:HP_0010111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010109 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:46:14Z" ; oboInOwl:hasAlternativeId "HP:0001843", "HP:0001861", "HP:0005610", "HP:0008105" ; oboInOwl:hasDbXref "UMLS:C1865992" ; oboInOwl:hasExactSynonym "Hypoplastic big toes", "Hypoplastic hallux", "Short big toe", "Short halluces", "Small hallux" ; oboInOwl:id "HP:0010109" ; a owl:Class ; rdfs:label "Short hallux" ; rdfs:subClassOf obo:HP_0001831, obo:HP_0008362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010110 dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:49:19Z" ; oboInOwl:hasDbXref "UMLS:C4024046" ; oboInOwl:hasExactSynonym "Absent bone of big toe" ; oboInOwl:id "HP:0010110" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the hallux" ; rdfs:subClassOf obo:HP_0010058, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010111 obo:IAO_0000115 "Underdevelopment (hypoplasia) of a phalanx of big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T12:49:19Z" ; oboInOwl:hasDbXref "UMLS:C4021334" ; oboInOwl:hasExactSynonym "Hypoplastic phalanges of the hallux", "Short bone of big toe" ; oboInOwl:id "HP:0010111" ; a owl:Class ; rdfs:label "Short phalanx of hallux" ; rdfs:subClassOf obo:HP_0010058, obo:HP_0010109, obo:HP_0010746 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010112 obo:IAO_0000115 "The presence of a supernumerary toe (not a hallux) involving the third or fourth metatarsal with associated osseous syndactyly." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:11:06Z" ; oboInOwl:hasDbXref "UMLS:C4021333" ; oboInOwl:hasExactSynonym "Central polydactyly of feet" ; oboInOwl:id "HP:0010112" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Mesoaxial foot polydactyly" ; rdfs:subClassOf obo:HP_0001829, obo:HP_0100260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0019242 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010113 obo:IAO_0000115 "Failure to form (agenesis) of one or more epiphyses of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4020906" ; oboInOwl:hasExactSynonym "Absent end part of big toe bone", "Absent epiphyses of the hallux" ; oboInOwl:id "HP:0010113" ; a owl:Class ; rdfs:label "Absent hallux epiphysis" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010162 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010114 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024045" ; oboInOwl:hasExactSynonym "Bracket shaped end part of big toe bone" ; oboInOwl:id "HP:0010114" ; a owl:Class ; rdfs:label "Bracket epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010115 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024044" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the big toe bone" ; oboInOwl:id "HP:0010115" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010116 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024043" ; oboInOwl:hasExactSynonym "Enlarged end part of the big toe bone" ; oboInOwl:id "HP:0010116" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010165 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010117 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024042" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the big toe bone" ; oboInOwl:id "HP:0010117" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010166 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010118 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024041" ; oboInOwl:hasExactSynonym "Irregular end part of big toe bone" ; oboInOwl:id "HP:0010118" ; a owl:Class ; rdfs:label "Irregular epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010119 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024040" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the big toe bone" ; oboInOwl:id "HP:0010119" ; a owl:Class ; rdfs:label "Ivory epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010120 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024039" ; oboInOwl:id "HP:0010120" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010169 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010121 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024038" ; oboInOwl:hasExactSynonym "Small end part of the big toe bone" ; oboInOwl:id "HP:0010121" ; a owl:Class ; rdfs:label "Small epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010170 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010122 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024037" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the big toe bone" ; oboInOwl:id "HP:0010122" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010171 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010123 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4024036" ; oboInOwl:hasExactSynonym "Triangular end part of the big toe bone" ; oboInOwl:id "HP:0010123" ; a owl:Class ; rdfs:label "Triangular epiphyses of the hallux" ; rdfs:subClassOf obo:HP_0010056, obo:HP_0010172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010124 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:17:54Z" ; oboInOwl:hasDbXref "UMLS:C4024035" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the big toe bone" ; oboInOwl:id "HP:0010124" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010125 obo:IAO_0000115 "In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities of the epiphysis of the first metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:17:54Z" ; oboInOwl:hasDbXref "UMLS:C4024034" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010125" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010126 obo:IAO_0000115 "In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities affecting the proximal phalanx of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:17:54Z" ; oboInOwl:hasDbXref "UMLS:C4024033" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010126" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010127 obo:IAO_0000115 "Failure to form (agenesis) of the epiphysis of the proximal phalanx of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024032" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010127" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010113, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010128 obo:IAO_0000115 "The epiphysis of the proximal phalanx of the hallux surrounds the diaphysis, having a bracket-like form." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024031" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of big toe" ; oboInOwl:id "HP:0010128" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010114, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010129 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024030" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010129" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010115, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010130 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024029" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010130" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010116, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010131 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024028" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010131" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010117, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010132 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024027" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010132" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010118, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010133 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024026" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010133" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010119, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010134 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the big toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024025" ; oboInOwl:id "HP:0010134" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010120, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010135 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024024" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010135" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010121, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010136 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024023" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010136" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010122, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010137 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:23Z" ; oboInOwl:hasDbXref "UMLS:C4024022" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost bone of the big toe" ; oboInOwl:id "HP:0010137" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010123, obo:HP_0010126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010138 obo:IAO_0000115 "Failure to form (agenesis) of the epiphysis of the distal phalanx of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024021" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010138" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010113, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010139 obo:IAO_0000115 "The epiphysis of the distal phalanx of the hallux surrounds the diaphysis, having a bracket-like form." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024020" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of big toe" ; oboInOwl:id "HP:0010139" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010114, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010140 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024019" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010140" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010115, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010141 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024018" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010141" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010116, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010142 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024017" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010142" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010117, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010143 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024016" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010143" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010118, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010144 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024015" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010144" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010119, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010145 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024014" ; oboInOwl:id "HP:0010145" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010120, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010146 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024013" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010146" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010121, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010147 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the hallux." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024012" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010147" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010122, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010148 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:22:47Z" ; oboInOwl:hasDbXref "UMLS:C4024011" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the big toe" ; oboInOwl:id "HP:0010148" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010123, obo:HP_0010124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010149 obo:IAO_0000115 "Failure to form (agenesis) of the epiphysis of the 1st metatarsal." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024010" ; oboInOwl:hasExactSynonym "Absent end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010149" ; a owl:Class ; rdfs:label "Absent epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004395 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003650 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010150 obo:IAO_0000115 "The epiphysis of the 1st metatarsal surrounds the diaphysis, having a bracket-like form." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024009" ; oboInOwl:hasExactSynonym "Bracket shaped end part of 1st long bone of foot" ; oboInOwl:id "HP:0010150" ; a owl:Class ; rdfs:label "Bracket epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010151 obo:IAO_0000115 "A conical (cone-shaped) appearance of the epiphysis of the first metatarsal of the foot." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024008" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010151" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010054, obo:HP_0010125, obo:HP_0010630 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010152 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024007" ; oboInOwl:hasExactSynonym "Enlarged end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010152" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010116, obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010153 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024006" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010153" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010117, obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010154 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024005" ; oboInOwl:hasExactSynonym "Irregular end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010154" ; a owl:Class ; rdfs:label "Irregular epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010118, obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010155 obo:IAO_0000115 "The epiphysis of the 1st metatarsal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024004" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010155" ; a owl:Class ; rdfs:label "Ivory epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010119, obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010156 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024003" ; oboInOwl:id "HP:0010156" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010157 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024002" ; oboInOwl:hasExactSynonym "Small end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010157" ; a owl:Class ; rdfs:label "Small epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010158 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024001" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010158" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010159 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:24:17Z" ; oboInOwl:hasDbXref "UMLS:C4024000" ; oboInOwl:hasExactSynonym "Triangular end part of the 1st long bone of foot" ; oboInOwl:id "HP:0010159" ; a owl:Class ; rdfs:label "Triangular epiphysis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0010125 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010160 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:30:42Z" ; oboInOwl:hasDbXref "UMLS:C4023999" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the toe bones", "Abnormality of the epiphyses of the toes" ; oboInOwl:id "HP:0010160" ; a owl:Class ; rdfs:label "Abnormal toe epiphysis morphology" ; rdfs:subClassOf obo:HP_0001780, obo:HP_0010631 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010161 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:31:17Z" ; oboInOwl:hasDbXref "UMLS:C4023998" ; oboInOwl:hasExactSynonym "Abnormality of the long bones of the toes", "Abnormality of the phalanges of the toes" ; oboInOwl:id "HP:0010161" ; a owl:Class ; rdfs:label "Abnormal toe phalanx morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010162 obo:IAO_0000115 "Absence of the epiphyses of the phalanges of the toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023997" ; oboInOwl:hasExactSynonym "Absent end part of the toe bones" ; oboInOwl:id "HP:0010162" ; a owl:Class ; rdfs:label "Absent epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010163 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023996" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the toe bones" ; oboInOwl:id "HP:0010163" ; a owl:Class ; rdfs:label "Bracket epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010578 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010164 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023995" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the toe bones" ; oboInOwl:id "HP:0010164" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0034281 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010165 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023994" ; oboInOwl:hasExactSynonym "Enlarged end part of the toe bones" ; oboInOwl:id "HP:0010165" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010166 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023993" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the toe bones" ; oboInOwl:id "HP:0010166" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0100168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010167 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023992" ; oboInOwl:hasExactSynonym "Irregular end part of the toe bones" ; oboInOwl:id "HP:0010167" ; a owl:Class ; rdfs:label "Irregular epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010582 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010168 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023991" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the toes" ; oboInOwl:id "HP:0010168" ; a owl:Class ; rdfs:label "Ivory epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010583 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010169 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023990" ; oboInOwl:id "HP:0010169" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010584 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010170 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023989" ; oboInOwl:hasExactSynonym "Small end part of the toe bones" ; oboInOwl:id "HP:0010170" ; a owl:Class ; rdfs:label "Small epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010171 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4021332" ; oboInOwl:hasExactSynonym "Speckled calcifications in long toe bones", "Stippling of the epiphyses of the toes" ; oboInOwl:id "HP:0010171" ; a owl:Class ; rdfs:label "Epiphyseal stippling of toe phalanges" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010655 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010172 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:34:06Z" ; oboInOwl:hasDbXref "UMLS:C4023988" ; oboInOwl:hasExactSynonym "Triangular end part of the toe bones" ; oboInOwl:id "HP:0010172" ; a owl:Class ; rdfs:label "Triangular epiphyses of the toes" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010173 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4023987" ; oboInOwl:hasExactSynonym "Absent/small toe bones", "Absent/underdeveloped toe bones" ; oboInOwl:id "HP:0010173" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the toes" ; rdfs:subClassOf obo:HP_0006494, obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010174 obo:IAO_0000115 "Increased width of phalanx of one or more toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4023986" ; oboInOwl:hasExactSynonym "Wide toe bones" ; oboInOwl:id "HP:0010174" ; a owl:Class ; rdfs:label "Broad phalanx of the toes" ; rdfs:subClassOf obo:HP_0006009, obo:HP_0010161, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010175 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4021331" ; oboInOwl:hasExactSynonym "Bullet-shaped phalanges of the toes", "Bullet-shaped toe bone" ; oboInOwl:id "HP:0010175" ; a owl:Class ; rdfs:label "Bullet-shaped toe phalanx" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010176 obo:IAO_0000115 "A deviation from the normal straight form of one or more toe phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4021330" ; oboInOwl:hasExactSynonym "Curved phalanges of the toes", "Curved toe bone" ; oboInOwl:id "HP:0010176" ; a owl:Class ; rdfs:label "Curved toe phalanx" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010177 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4023985" ; oboInOwl:id "HP:0010177" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the toes" ; rdfs:subClassOf obo:HP_0009134, obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010178 obo:IAO_0000115 "Uneven (irregular) increase in bone density of one or more of the phalanges of the foot." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4021329" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the toes", "Uneven increase in bone density in toe bone" ; oboInOwl:id "HP:0010178" ; a owl:Class ; rdfs:label "Patchy sclerosis of toe phalanx" ; rdfs:subClassOf obo:HP_0005686, obo:HP_0100924 . obo:HP_0010179 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4023984" ; oboInOwl:hasExactSynonym "Fused toe bones" ; oboInOwl:id "HP:0010179" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the toes" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010180 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4023983" ; oboInOwl:hasExactSynonym "Triangular shaped toe bones" ; oboInOwl:id "HP:0010180" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the toes" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010181 obo:IAO_0000115 "Partial/complete duplication of one or more phalanx of toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:39:26Z" ; oboInOwl:hasDbXref "UMLS:C4021328" ; oboInOwl:hasExactSynonym "Duplicated toe bone", "Partial/complete duplication of the phalanges of the toes" ; oboInOwl:id "HP:0010181" ; a owl:Class ; rdfs:label "Duplication of phalanx of toe" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010182 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:51:38Z" ; oboInOwl:hasDbXref "UMLS:C4023982" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of the toes" ; oboInOwl:id "HP:0010182" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010183 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:51:38Z" ; oboInOwl:hasDbXref "UMLS:C4023981" ; oboInOwl:hasExactSynonym "Abnormal middle bones of toe" ; oboInOwl:id "HP:0010183" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010184 obo:IAO_0000115 "A morphological anomaly of one or more proximal phalanges of one or more toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:51:38Z" ; oboInOwl:hasDbXref "UMLS:C4021327" ; oboInOwl:hasExactSynonym "Abnormal innermost toe bone", "Abnormality of the proximal phalanges of the toes" ; oboInOwl:id "HP:0010184" ; a owl:Class ; rdfs:label "Abnormality of toe proximal phalanx" ; rdfs:subClassOf obo:HP_0010161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010185 obo:IAO_0000115 "Absence or underdevelopment of the distal phalanges of the toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasAlternativeId "HP:0005735", "HP:0005818" ; oboInOwl:hasDbXref "UMLS:C4020773", "UMLS:C4021326" ; oboInOwl:hasExactSynonym "Absent/hypoplastic terminal phalanges of toes", "Absent/small outermost bones of toe", "Absent/underdeveloped outermost bones of toe" ; oboInOwl:hasRelatedSynonym "Hypoplasia/agenesis of distal phalanges of toes" ; oboInOwl:id "HP:0010185" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010182, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010186 obo:IAO_0000115 "Increased width of the distal phalanx of toe of one or more toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4023980" ; oboInOwl:hasExactSynonym "Broad outermost bone of the toe", "Wide outermost bone of the toe" ; oboInOwl:id "HP:0010186" ; a owl:Class ; rdfs:label "Broad distal phalanx of the toes" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010187 obo:IAO_0000115 "An abnormal morphology of one or more distal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4021325" ; oboInOwl:hasExactSynonym "Bullet-shaped distal phalanges of the toes", "Bullet-shaped outermost bone of the toe" ; oboInOwl:id "HP:0010187" ; a owl:Class ; rdfs:label "Bullet-shaped distal toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010188 obo:IAO_0000115 "A deviation from the normal straight form of one or more distal toe phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4021324" ; oboInOwl:hasExactSynonym "Curved distal phalanges of the toes", "Curved outermost bone of the toe" ; oboInOwl:id "HP:0010188" ; a owl:Class ; rdfs:label "Curved distal toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010189 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4023979" ; oboInOwl:id "HP:0010189" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003867 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010190 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the distal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4021323" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the distal phalanges of the toes", "Uneven increase in bone density in outermost toe bone" ; oboInOwl:id "HP:0010190" ; a owl:Class ; rdfs:label "Patchy sclerosis of distal toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003867 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010191 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4023978" ; oboInOwl:hasExactSynonym "Fused outermost bones of toes" ; oboInOwl:id "HP:0010191" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010192 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4023977" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the toes" ; oboInOwl:id "HP:0010192" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010193 obo:IAO_0000115 "A partial or complete duplication of one or more distal phalanx of toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:52:41Z" ; oboInOwl:hasDbXref "UMLS:C4021322" ; oboInOwl:hasExactSynonym "Duplication of outermost bone of toe", "Partial/complete duplication of the distal phalanges of the toes" ; oboInOwl:id "HP:0010193" ; a owl:Class ; rdfs:label "Duplication of distal phalanx of toe" ; rdfs:subClassOf obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010194 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4023976" ; oboInOwl:hasExactSynonym "Absent/small middle bones of toe", "Absent/underdeveloped middle bones of toe" ; oboInOwl:id "HP:0010194" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010195 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4023975" ; oboInOwl:hasExactSynonym "Broad middle bones of the toes" ; oboInOwl:id "HP:0010195" ; a owl:Class ; rdfs:label "Broad middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010196 obo:IAO_0000115 "An abnormal morphology of one or more middle phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4021321" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bones of the toes", "Bullet-shaped middle phalanges of the toes" ; oboInOwl:id "HP:0010196" ; a owl:Class ; rdfs:label "Bullet-shaped middle toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010197 obo:IAO_0000115 "A deviation from the normal straight form of one or more middle toe phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4021320" ; oboInOwl:hasExactSynonym "Curved middle bones of the toes", "Curved middle phalanges of the toes" ; oboInOwl:id "HP:0010197" ; a owl:Class ; rdfs:label "Curved middle toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010198 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4023974" ; oboInOwl:id "HP:0010198" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003866 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010199 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the middle phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4021319" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the middle phalanges of the toes", "Uneven increase in bone density in middle toe bone" ; oboInOwl:id "HP:0010199" ; a owl:Class ; rdfs:label "Patchy sclerosis of middle toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003866 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010200 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4023973" ; oboInOwl:hasExactSynonym "Fused middle bones of toes" ; oboInOwl:id "HP:0010200" ; a owl:Class ; rdfs:label "Symphalangism affecting the middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010201 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4023972" ; oboInOwl:hasExactSynonym "Triangular shaped middle bones of toes" ; oboInOwl:id "HP:0010201" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010202 obo:IAO_0000115 "Partial or complete duplication of a middle phalanx of toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:53:35Z" ; oboInOwl:hasDbXref "UMLS:C4021318" ; oboInOwl:hasExactSynonym "Partial/complete duplication of the middle bones of the toes", "Partial/complete duplication of the middle phalanges of the toes" ; oboInOwl:id "HP:0010202" ; a owl:Class ; rdfs:label "Duplication of middle phalanx of toe" ; rdfs:subClassOf obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010203 obo:IAO_0000115 "Absence (agenesis) or underdevelopment of the proximal phalanx of the toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021317" ; oboInOwl:hasExactSynonym "Absent/small innermost toe bones", "Absent/underdeveloped innermost toe bones", "Aplasia/Hypoplasia of the proximal phalanges of the toes" ; oboInOwl:id "HP:0010203" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010204 obo:IAO_0000115 "An increase in width of one ore more proximal toe phalanges." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4023971" ; oboInOwl:hasExactSynonym "Broad innermost toe bone" ; oboInOwl:id "HP:0010204" ; a owl:Class ; rdfs:label "Broad proximal phalanx of toe" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010205 obo:IAO_0000115 "An abnormal morphology of one or more of the proximal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021316" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost toe bone", "Bullet-shaped proximal phalanges of the toes", "Bullet-shaped proximal phalanges of toe" ; oboInOwl:id "HP:0010205" ; a owl:Class ; rdfs:label "Bullet-shaped proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010206 obo:IAO_0000115 "A deviation from the normal straight shape of a proximal phalanx of one or more toes." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021315" ; oboInOwl:hasExactSynonym "Curved innermost toe bones", "Curved proximal phalanges of the toes" ; oboInOwl:id "HP:0010206" ; a owl:Class ; rdfs:label "Curved proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010207 obo:IAO_0000115 "Dissolution or degeneration of bone tissue of the proximal toe phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021314" ; oboInOwl:hasExactSynonym "Osteolytic defects of the proximal phalanges of the toes" ; oboInOwl:id "HP:0010207" ; a owl:Class ; rdfs:label "Osteolytic defect of the proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003868 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010208 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the proximal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021313" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the proximal phalanges of the toes", "Uneven increase in bone density in innermost toe bone" ; oboInOwl:id "HP:0010208" ; a owl:Class ; rdfs:label "Patchy sclerosis of proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0100946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003868 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010209 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4023970" ; oboInOwl:hasExactSynonym "Fused innermost bones of toes" ; oboInOwl:id "HP:0010209" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010210 dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4023969" ; oboInOwl:hasExactSynonym "Triangular shaped innermost toe bones" ; oboInOwl:id "HP:0010210" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010211 obo:IAO_0000115 "Partial/complete duplication of a proximal phalanx of toe." ; dcterms:creator ; oboInOwl:creation_date "2009-05-29T01:54:18Z" ; oboInOwl:hasDbXref "UMLS:C4021312" ; oboInOwl:hasExactSynonym "Duplication of innermost toe bones", "Partial/complete duplication of the proximal phalanges of the toes" ; oboInOwl:id "HP:0010211" ; a owl:Class ; rdfs:label "Duplication of proximal phalanx of toe" ; rdfs:subClassOf obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010212 obo:IAO_0000115 "One or more bent (flexed) joints of the first (big) toe that cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-06-02T01:39:18Z" ; oboInOwl:hasDbXref "UMLS:C4021311" ; oboInOwl:hasExactSynonym "Joint contracture of the big toe", "Joint contracture of the hallux" ; oboInOwl:id "HP:0010212" ; a owl:Class ; rdfs:label "Flexion contracture of the hallux" ; rdfs:subClassOf obo:HP_0001844, obo:HP_0005830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010213 obo:IAO_0000115 "Chronic loss of joint motion in the tarsometatarsal joint of the hallux due to structural changes in non-bony tissue. The tarsometatarsal joints of the feet are also called Lisfranc's joints." ; dcterms:creator ; oboInOwl:creation_date "2009-06-02T01:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023968" ; oboInOwl:id "HP:0010213" ; a owl:Class ; rdfs:label "Contracture of the tarsometatarsal joint of the hallux" ; rdfs:subClassOf obo:HP_0010212 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011118 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010214 obo:IAO_0000115 "The interphalangeal joint of the big toe cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-06-02T01:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023967" ; oboInOwl:id "HP:0010214" ; a owl:Class ; rdfs:label "Contracture of the interphalangeal joint of the hallux" ; rdfs:subClassOf obo:HP_0010212 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006658 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010215 obo:IAO_0000115 "The joint between the first metatarsal and the proximal phalanx of the first (big) toe cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-06-02T01:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023966" ; oboInOwl:id "HP:0010215" ; a owl:Class ; rdfs:label "Contractures of the metatarsophalangeal joint of the hallux" ; rdfs:subClassOf obo:HP_0010212 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007750 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010219 obo:IAO_0000115 "A foot deformity resulting due to an abnormality affecting the bones of the foot (as well as muscle and soft tissue). In contrast if only the muscle and soft tissue are affected the term positional foot deformity applies." ; dcterms:creator ; oboInOwl:creation_date "2009-06-04T05:14:38Z" ; oboInOwl:hasDbXref "UMLS:C4023965" ; oboInOwl:id "HP:0010219" ; a owl:Class ; rdfs:label "Structural foot deformity" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0010220 obo:IAO_0000115 "Any abnormality of the epiphysis of the second metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:07:33Z" ; oboInOwl:hasDbXref "UMLS:C4023964" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 2nd long bone of hand" ; oboInOwl:id "HP:0010220" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 2nd metacarpal" ; rdfs:subClassOf obo:HP_0010010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003646 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010221 obo:IAO_0100001 "HP:0006179" ; a owl:Class ; rdfs:label "obsolete Pseudoepiphysis of the 2nd metacarpal" ; owl:deprecated true . obo:HP_0010222 obo:IAO_0000115 "Any abnormality of the epiphysis of the third metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:10:28Z" ; oboInOwl:hasDbXref "UMLS:C4023962" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 3rd long bone of hand" ; oboInOwl:id "HP:0010222" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0010011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004390 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003647 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010223 obo:IAO_0000115 "The normal epiphysis of the third metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:10:52Z" ; oboInOwl:hasDbXref "UMLS:C4023961" ; oboInOwl:id "HP:0010223" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the 3rd metacarpal" ; rdfs:subClassOf obo:HP_0010222 . obo:HP_0010224 obo:IAO_0000115 "Any abnormality of the epiphysis of the 4th metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:11:46Z" ; oboInOwl:hasDbXref "UMLS:C4023960" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 4th long bone of hand" ; oboInOwl:id "HP:0010224" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 4th metacarpal" ; rdfs:subClassOf obo:HP_0010012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003648 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010225 obo:IAO_0000115 "The normal epiphysis of the fourth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:12:04Z" ; oboInOwl:hasDbXref "UMLS:C4023959" ; oboInOwl:id "HP:0010225" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the 4th metacarpal" ; rdfs:subClassOf obo:HP_0010224 . obo:HP_0010226 obo:IAO_0000115 "Any abnormality of the epiphysis of the fifth metacarpal bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4023958" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the long bone of little finger", "Abnormality of the end part of the long bone of pinkie finger", "Abnormality of the end part of the long bone of pinky finger" ; oboInOwl:id "HP:0010226" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the 5th metacarpal" ; rdfs:subClassOf obo:HP_0010013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004390 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003649 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010227 obo:IAO_0000115 "The normal epiphysis of the fifth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." ; dcterms:creator ; oboInOwl:creation_date "2009-07-02T04:13:20Z" ; oboInOwl:hasDbXref "UMLS:C4023957" ; oboInOwl:id "HP:0010227" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the 5th metacarpal" ; rdfs:subClassOf obo:HP_0010226 . obo:HP_0010228 obo:IAO_0000115 "Absence of one or more epiphyses of the phalanges of the fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009359" ; oboInOwl:hasDbXref "UMLS:C4021310" ; oboInOwl:hasExactSynonym "Absent end part of fingers", "Absent epiphyses of the fingers" ; oboInOwl:id "HP:0010228" ; a owl:Class ; rdfs:label "Absent epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010577 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010229 obo:IAO_0000115 "Bracket epiphysis refers to an abnormality in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009360" ; oboInOwl:hasDbXref "UMLS:C4021309" ; oboInOwl:hasExactSynonym "Bracket epiphyses of the fingers", "Bracket shaped end part of finger bones" ; oboInOwl:id "HP:0010229" ; a owl:Class ; rdfs:label "Bracket epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010578 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010230 obo:IAO_0000115 "A cone-shaped appearance of the epiphyses of the fingers of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0001175", "HP:0001207", "HP:0001242", "HP:0003766", "HP:0005803", "HP:0009361" ; oboInOwl:hasDbXref "UMLS:C1859480" ; oboInOwl:hasExactSynonym "Cone-shaped end part of finger bones", "Cone-shaped epiphyses of hand", "Cone-shaped epiphyses of the fingers", "Coned epiphyses of hands", "Conical phalangeal epiphyses" ; oboInOwl:id "HP:0010230" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0034281 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010231 obo:IAO_0000115 "Abnormally large size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0006023", "HP:0009362" ; oboInOwl:hasDbXref "UMLS:C1865036" ; oboInOwl:hasExactSynonym "Enlarged end part of finger bones", "Enlarged epiphyses of the fingers", "Enlarged phalangeal epiphyses" ; oboInOwl:id "HP:0010231" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010232 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the phalanges of the fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009363" ; oboInOwl:hasDbXref "UMLS:C4021308" ; oboInOwl:hasExactSynonym "Fragmentation of end part of finger bones", "Fragmentation of the epiphyses of the fingers" ; oboInOwl:id "HP:0010232" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0003841, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010233 obo:IAO_0000115 "Irregular radiographic opacity of the epiphyses of the phalanges of the fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009364" ; oboInOwl:hasDbXref "UMLS:C4021307" ; oboInOwl:hasExactSynonym "Irregular end part of finger bones", "Irregular epiphyses of the fingers" ; oboInOwl:id "HP:0010233" ; a owl:Class ; rdfs:label "Irregular epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0003842, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010234 obo:IAO_0000115 "Sclerosis of the epiphyses of the phalanges of the fingers, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0001210", "HP:0009365" ; oboInOwl:hasDbXref "UMLS:C1857651" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the hand bones", "Ivory epiphyses of the fingers", "Sclerotic ivory phalangeal epiphyses" ; oboInOwl:id "HP:0010234" ; a owl:Class ; rdfs:label "Ivory epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010583, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010235 obo:IAO_0000115 "A secondary ossification center in the phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009366" ; oboInOwl:hasDbXref "UMLS:C4021306" ; oboInOwl:hasExactSynonym "Pseudoepiphysis of the fingers" ; oboInOwl:id "HP:0010235" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0004288, obo:HP_0005920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010236 obo:IAO_0000115 "Abnormally small size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009367" ; oboInOwl:hasDbXref "UMLS:C4021305" ; oboInOwl:hasExactSynonym "Small end part of finger bones", "Small epiphyses of the fingers" ; oboInOwl:id "HP:0010236" ; a owl:Class ; rdfs:label "Small epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010237 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the fingers." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009368" ; oboInOwl:hasDbXref "UMLS:C4021304" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of finger bones", "Stippling of the epiphyses of the fingers", "Stippling of the epiphyses of the phalanges of the hand" ; oboInOwl:id "HP:0010237" ; a owl:Class ; rdfs:label "Epiphyseal stippling of finger phalanges" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010655, obo:HP_0010660 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010238 obo:IAO_0000115 "A triangular appearance of the epiphyses of the phalanges of the fingers of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:31:52Z" ; oboInOwl:hasAlternativeId "HP:0009369" ; oboInOwl:hasDbXref "UMLS:C4021303" ; oboInOwl:hasExactSynonym "Delta-shaped epiphyses of the fingers", "Triangular end part of finger bones", "Triangular epiphyses of the fingers" ; oboInOwl:id "HP:0010238" ; a owl:Class ; rdfs:label "Triangular epiphyses of the phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0010587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010239 obo:IAO_0000115 "Absence of one or more middle phalanx of a finger." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T03:59:39Z" ; oboInOwl:hasAlternativeId "HP:0005778" ; oboInOwl:hasDbXref "UMLS:C1862096" ; oboInOwl:hasExactSynonym "Absent middle bones of hand", "Absent middle phalanges", "Missing middle phalanges" ; oboInOwl:id "HP:0010239" ; a owl:Class ; rdfs:label "Aplasia of the middle phalanx of the hand" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0009802, obo:HP_0009843 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010241 obo:IAO_0000115 "Congenital hypoplasia of one or more proximal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:00:44Z" ; oboInOwl:hasAlternativeId "HP:0005670", "HP:0006138" ; oboInOwl:hasDbXref "UMLS:C1860606" ; oboInOwl:hasExactSynonym "Hypoplasia of the proximal phalanges of the hand", "Short innermost finger bones", "Short proximal phalanges", "Short proximal phalanx of finger", "Shortening in proximal phalanges" ; oboInOwl:id "HP:0010241" ; a owl:Class ; rdfs:label "Short proximal phalanx of finger" ; rdfs:subClassOf obo:HP_0009381, obo:HP_0009803, obo:HP_0009851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010242 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:01:02Z" ; oboInOwl:hasAlternativeId "HP:0006102" ; oboInOwl:hasDbXref "UMLS:C4021302" ; oboInOwl:hasExactSynonym "Absent innermost bones", "Absent proximal phalanges" ; oboInOwl:id "HP:0010242" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0009380, obo:HP_0009802, obo:HP_0009851 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010243 obo:IAO_0000115 "Any anomaly of distal epiphysis of phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:21:32Z" ; oboInOwl:hasDbXref "UMLS:C4023956" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of finger" ; oboInOwl:id "HP:0010243" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the distal phalanx of finger" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010244 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:21:32Z" ; oboInOwl:hasDbXref "UMLS:C4023955" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle hand bones" ; oboInOwl:id "HP:0010244" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010245 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:21:32Z" ; oboInOwl:hasDbXref "UMLS:C4023954" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost hand bones" ; oboInOwl:id "HP:0010245" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0005920, obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010246 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023953" ; oboInOwl:hasExactSynonym "Absent end part of the outermost hand bones" ; oboInOwl:id "HP:0010246" ; a owl:Class ; rdfs:label "Absent epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010228, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010247 obo:IAO_0000115 "An abnormality of the distal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023952" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost hand bones" ; oboInOwl:id "HP:0010247" ; a owl:Class ; rdfs:label "Bracket epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010229, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010248 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023951" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost hand bones" ; oboInOwl:id "HP:0010248" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010230, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010249 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023950" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost hand bones" ; oboInOwl:id "HP:0010249" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010231, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010250 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023949" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost hand bones" ; oboInOwl:id "HP:0010250" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010232, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010251 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023948" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost hand bones" ; oboInOwl:id "HP:0010251" ; a owl:Class ; rdfs:label "Irregular epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010233, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010252 obo:IAO_0000115 "Distal epiphyses of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasAlternativeId "HP:0006105" ; oboInOwl:hasDbXref "UMLS:C4021301" ; oboInOwl:hasExactSynonym "Eburnated epiphyses of distal phalanges", "Increased bone density of end part of the outermost hand bones" ; oboInOwl:id "HP:0010252" ; a owl:Class ; rdfs:label "Ivory epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010234, obo:HP_0010243, obo:HP_0100915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010253 obo:IAO_0000115 "A secondary ossification center in the distal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023947" ; oboInOwl:id "HP:0010253" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010235, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010254 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023946" ; oboInOwl:hasExactSynonym "Small end part of the outermost hand bones" ; oboInOwl:id "HP:0010254" ; a owl:Class ; rdfs:label "Small epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010236, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010255 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023945" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost hand bones" ; oboInOwl:id "HP:0010255" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010237, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010256 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4023944" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost hand bones" ; oboInOwl:id "HP:0010256" ; a owl:Class ; rdfs:label "Triangular epiphyses of the distal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010238, obo:HP_0010243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010257 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023943" ; oboInOwl:hasExactSynonym "Absent end part of the middle hand bones" ; oboInOwl:id "HP:0010257" ; a owl:Class ; rdfs:label "Absent epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010228, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010258 obo:IAO_0000115 "An abnormality of the middle phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023942" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle hand bones" ; oboInOwl:id "HP:0010258" ; a owl:Class ; rdfs:label "Bracket epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010229, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010259 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasAlternativeId "HP:0006033", "HP:0006058" ; oboInOwl:hasDbXref "UMLS:C1860828" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle hand bones", "Cone-shaped epiphyses of middle phalanges" ; oboInOwl:id "HP:0010259" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010230, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010260 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023941" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle hand bones" ; oboInOwl:id "HP:0010260" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010231, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010261 obo:IAO_0000115 "Fragmented appearance of the epiphyses of the middle phalanges of the hand." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023940" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the middle hand bones" ; oboInOwl:id "HP:0010261" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010232, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010262 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023939" ; oboInOwl:hasExactSynonym "Irregular end part of middle hand bones" ; oboInOwl:id "HP:0010262" ; a owl:Class ; rdfs:label "Irregular epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010233, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010263 obo:IAO_0000115 "Epiphyses of the middle phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023938" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle hand bones" ; oboInOwl:id "HP:0010263" ; a owl:Class ; rdfs:label "Ivory epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010234, obo:HP_0010244, obo:HP_0100916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010264 obo:IAO_0000115 "A secondary ossification center in the middle phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023937" ; oboInOwl:id "HP:0010264" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010235, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010265 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023936" ; oboInOwl:hasExactSynonym "Small end part of the middle hand bones" ; oboInOwl:id "HP:0010265" ; a owl:Class ; rdfs:label "Small epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010236, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010266 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023935" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the middle hand bones" ; oboInOwl:id "HP:0010266" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010237, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010267 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:24:15Z" ; oboInOwl:hasDbXref "UMLS:C4023934" ; oboInOwl:hasExactSynonym "Triangular end part of the middle hand bones" ; oboInOwl:id "HP:0010267" ; a owl:Class ; rdfs:label "Triangular epiphyses of the middle phalanges of the hand" ; rdfs:subClassOf obo:HP_0010238, obo:HP_0010244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010268 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023933" ; oboInOwl:hasExactSynonym "Absent end part of the innermost hand bones" ; oboInOwl:id "HP:0010268" ; a owl:Class ; rdfs:label "Absent epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010228, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010269 obo:IAO_0000115 "An abnormality of the proximal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023932" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost hand bones" ; oboInOwl:id "HP:0010269" ; a owl:Class ; rdfs:label "Bracket epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010229, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010270 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023931" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost hand bones" ; oboInOwl:id "HP:0010270" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010230, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010271 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023930" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost hand bones" ; oboInOwl:id "HP:0010271" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010231, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010272 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023929" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost hand bones" ; oboInOwl:id "HP:0010272" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010232, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002234 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010273 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023928" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost hand bones" ; oboInOwl:id "HP:0010273" ; a owl:Class ; rdfs:label "Irregular epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010233, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010274 obo:IAO_0000115 "Epiphyses of the proximal phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023927" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost hand bones" ; oboInOwl:id "HP:0010274" ; a owl:Class ; rdfs:label "Ivory epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010234, obo:HP_0010245, obo:HP_0100917 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010275 obo:IAO_0000115 "A secondary ossification center in the proximal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." ; dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023926" ; oboInOwl:id "HP:0010275" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010235, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010276 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023925" ; oboInOwl:hasExactSynonym "Small end part of the innermost hand bones" ; oboInOwl:id "HP:0010276" ; a owl:Class ; rdfs:label "Small epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010236, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010277 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023924" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the innermost hand bones" ; oboInOwl:id "HP:0010277" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010237, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010278 dcterms:creator ; oboInOwl:creation_date "2009-07-06T04:25:12Z" ; oboInOwl:hasDbXref "UMLS:C4023923" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost hand bones" ; oboInOwl:id "HP:0010278" ; a owl:Class ; rdfs:label "Triangular epiphyses of the proximal phalanges of the hand" ; rdfs:subClassOf obo:HP_0010238, obo:HP_0010245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004387 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010280 obo:IAO_0000115 "Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T09:48:56Z" ; oboInOwl:hasDbXref "MSH:D013280", "SNOMEDCT_US:20607006", "SNOMEDCT_US:61170000", "UMLS:C0038362", "UMLS:C0149704" ; oboInOwl:hasExactSynonym "Inflammation of the mouth" ; oboInOwl:hasNarrowSynonym "Gingivostomatitis" ; oboInOwl:id "HP:0010280" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Stomatitis" ; rdfs:subClassOf obo:HP_0011830, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003729 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010281 obo:IAO_0000115 "A gap in the lower lip." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T09:50:34Z" ; oboInOwl:hasDbXref "UMLS:C1856026" ; oboInOwl:hasExactSynonym "Cleft lower lip", "Cleft of the lower lip", "Lower labial cleft" ; oboInOwl:id "HP:0010281" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cleft lower lip" ; rdfs:subClassOf obo:HP_0000178, obo:HP_0410030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010282 obo:IAO_0000115 "Height of the vermilion of the medial part of the lower lip more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the lower lip in the frontal view (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:17:22Z" ; oboInOwl:hasDbXref "UMLS:C2053440" ; oboInOwl:hasExactSynonym "Decreased height of lower lip vermilion", "Decreased volume of lower lip", "Decreased volume of lower lip vermilion", "Thin lower lip", "Thin vermilion border of lower lip" ; oboInOwl:hasNarrowSynonym "Thin red part of the lower lip" ; oboInOwl:id "HP:0010282" ; a owl:Class ; rdfs:comment "Normal values for the height of the vermilion are available [Farkas, 1981] but measurements are not commonly used. Most clinicians determine this feature subjectively. The height of the vermilion of the lower lip varies considerably among ethnic groups, and the vermilion should be compared to a population of same ethnic background. If the lower lip vermilion is thin, the inferior border of the vermilion is less curved, and on a profile view, the lower lip vermilion is less convex than usual." ; rdfs:label "Thin lower lip vermilion" ; rdfs:subClassOf obo:HP_0000178, obo:HP_0000233 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010284 obo:IAO_0000115 "Increased pigmentation, either focal or generalized, of the mucosa of the mouth." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:33:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:235038002", "UMLS:C0399483", "UMLS:C0877541", "UMLS:C4280387", "UMLS:C4280388", "UMLS:C4280389" ; oboInOwl:hasExactSynonym "Hyperpigmentation of oral mucosa", "Oral mucosa melanin pigmentation", "Oral racial pigmentation" ; oboInOwl:hasNarrowSynonym "Dark color of gums", "Dark colour of gums", "Gingival hyperpigmentation", "Gingival melanin pigmentation", "Pigmented gums" ; oboInOwl:id "HP:0010284" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Pigmentation of alveolar ridges is common in people with dark skin pigmentation. This term encompasses a range of pigmentary findings, from freckles to generalized hyperpigmentation." ; rdfs:label "Intra-oral hyperpigmentation" ; rdfs:subClassOf obo:HP_0100669 . obo:HP_0010285 obo:IAO_0000115 "Fibrous band between the mucosal surfaces of the upper and lower alveolar ridges." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:37:03Z" ; oboInOwl:hasBroadSynonym "Oral fibrous bands" ; oboInOwl:hasDbXref "UMLS:C4023921" ; oboInOwl:hasExactSynonym "Synechiae of the mouth" ; oboInOwl:id "HP:0010285" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "These bands must be distinguished from synechiaee between the tongue and palate (glossopalatal ankylosis) and from synechiae arising from the floor of the mouth (as in the subglossopalatal membrane), oropharyngeal isthmus (as in persistent buccopharyngeal membrane) or from the lower lip. If there is a complete soft tissue contiguity between the upper and lower alveolar ridges, the term, Fibrous syngnathia should be used instead." ; rdfs:label "Oral synechia" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0010286 obo:IAO_0000115 "Any abnormality of the salivary glands, the exocrine glands that produce saliva." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:38:51Z" ; oboInOwl:hasDbXref "MSH:D012466", "SNOMEDCT_US:10890000", "UMLS:C0036093", "UMLS:C0149772" ; oboInOwl:hasExactSynonym "Abnormality of the salivary glands" ; oboInOwl:hasRelatedSynonym "Salivary gland disease" ; oboInOwl:id "HP:0010286" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal salivary gland morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001044 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010287 obo:IAO_0000115 "Any abnormality of the submandibular glands, which are the salivary glands that are located beneath the floor of the mouth, superior to the digastric muscles." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:41:17Z" ; oboInOwl:hasDbXref "UMLS:C4023920" ; oboInOwl:hasExactSynonym "Abnormality of the submaxillary glands" ; oboInOwl:id "HP:0010287" ; a owl:Class ; rdfs:label "Abnormality of the submandibular glands" ; rdfs:subClassOf obo:HP_0010286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001736 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010288 obo:IAO_0000115 "Any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:42:35Z" ; oboInOwl:hasDbXref "UMLS:C4023919" ; oboInOwl:id "HP:0010288" ; a owl:Class ; rdfs:label "Abnormality of the sublingual glands" ; rdfs:subClassOf obo:HP_0010286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001832 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010289 obo:IAO_0000115 "A gap (cleft) affecting one of the alveolar ridges, which are the protuberances in the mouth that contain the sockets (alveoli) of the teeth. An alveolar cleft can affect all structures of the alveolar ridge, including the gingiva, other mucosa, periosteum, alveolar bone, and teeth. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T10:47:29Z" ; oboInOwl:hasAlternativeId "HP:0410003" ; oboInOwl:hasDbXref "SNOMEDCT_US:445306000", "UMLS:C1398533", "UMLS:C2919907", "UMLS:C4280386" ; oboInOwl:hasExactSynonym "Alveolar cleft", "Alveolar ridge cleft", "Cleft anterior maxilla", "Cleft maxillary alveolus", "Cleft of alveolar ridge of maxilla", "Cleft of gum ridge", "Notch of alveolar ridge", "Notch of gum ridge" ; oboInOwl:hasNarrowSynonym "Cleft of alveolar process", "Notch of alveolar process" ; oboInOwl:id "HP:0010289" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The palate develops from the frontonasal and maxillary prominences between 4 and 12 weeks of gestation. During gestational weeks 4 to 7, the primary palate originates from the median palatine process, which itself originated from frontonasal prominence. The lip, alveolus, and hard palate anterior to the incisive foramen all share this origin in development. During this period, disruptions of palatal development process can result in primary palate clefting. The secondary palate develops from the lateral palatine processes originating from the maxillary prominences between 7 and 12 weeks, and the hard palate posterior to incisive foramen and the soft palate are developmental products of this process. As such, disruptions during this time will result in secondary palate clefts. The alveolus is a component of the primary palate, and alveolar cleft results from mal-development of the frontonasal prominence. As such, it is most closely related to cleft lip and cleft palate. Generally, alveolar clefts are located between the lateral incisor and canine." ; rdfs:label "Cleft maxillary alveolar ridge" ; rdfs:subClassOf obo:HP_0000202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010290 obo:IAO_0000115 "Distance between the labial point of the incisive papilla to the midline junction of the hard and soft palate more than 2 SD below the mean (objective) or apparently decreased length of the hard palate (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:28:44Z" ; oboInOwl:hasDbXref "UMLS:C1398301", "UMLS:C4020772", "UMLS:C4023918" ; oboInOwl:hasExactSynonym "Decreased length of hard palate" ; oboInOwl:hasRelatedSynonym "Hypoplastic palate", "Short palate" ; oboInOwl:id "HP:0010290" ; a owl:Class ; rdfs:comment "Objective measurement of the hard palate requires special instrumentation [Hall JG, Froster-Iskenius UG, Allanson JE, Gripp K, Slavotinek A. 2006. Handbook of Normal Physical Measurements. 2nd edition. Oxford Medical, publishers]. A short hard palate may be associated with velopharyngeal incompetence." ; rdfs:label "Short hard palate" ; rdfs:subClassOf obo:HP_0100737 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003216 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010291 obo:IAO_0000115 "Increased size and/or number of soft tissue folds on the palatal side of the maxillary alveolar ridge." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:33:40Z" ; oboInOwl:hasDbXref "UMLS:C4021300" ; oboInOwl:hasExactSynonym "Large lateral palatal folds", "Large lateral palatal ridges", "Prominent lateral palatal folds", "Prominent lateral palatal ridges", "Prominent palatine folds" ; oboInOwl:id "HP:0010291" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Soft tissue folds are typically present on the lateral sides of the palate, especially anteriorly." ; rdfs:label "Prominent palatine ridges" ; rdfs:subClassOf obo:HP_0000174 . obo:HP_0010292 obo:IAO_0000115 "Lack of the uvula." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:36:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:25148007", "UMLS:C0266121" ; oboInOwl:hasExactSynonym "Absent palatine uvula", "Congenital absence of uvula", "Missing uvula", "Uvula aplasia" ; oboInOwl:hasRelatedSynonym "Agenesis of uvula" ; oboInOwl:id "HP:0010292" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Sometimes accompanies a Submucous cleft palate, but this should be coded separately." ; rdfs:label "Absent uvula" ; rdfs:subClassOf obo:HP_0010293 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010293 obo:IAO_0000115 "Underdevelopment or absence of the uvula." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:36:52Z" ; oboInOwl:hasDbXref "UMLS:C4023917" ; oboInOwl:hasExactSynonym "Aplasia/hypoplasia of palatine uvula" ; oboInOwl:id "HP:0010293" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the uvula" ; rdfs:subClassOf obo:HP_0000172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010294 obo:IAO_0000115 "A fistula which connects the oral cavity and the pharyngeal area via the aspects of the soft palate." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:39:52Z" ; oboInOwl:hasBroadSynonym "Hole in roof of mouth", "Palatal hole", "Palatal perforation" ; oboInOwl:hasDbXref "UMLS:C2032780", "UMLS:C4280385" ; oboInOwl:id "HP:0010294" ; a owl:Class ; rdfs:label "Palate fistula" ; rdfs:subClassOf obo:HP_0000174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001716 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010295 obo:IAO_0000115 "Absence or underdevelopment of the tongue." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:41:04Z" ; oboInOwl:hasDbXref "UMLS:C4023916", "UMLS:C4280384" ; oboInOwl:hasExactSynonym "Lingual aplasia/hypoplasia" ; oboInOwl:id "HP:0010295" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010296 obo:IAO_0000115 "Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:44:22Z" ; oboInOwl:hasDbXref "MSH:D000072676", "SNOMEDCT_US:67787004", "UMLS:C0152415" ; oboInOwl:hasExactSynonym "Tongue tied" ; oboInOwl:hasRelatedSynonym "Tongue tie" ; oboInOwl:id "HP:0010296" ; a owl:Class ; rdfs:comment "The anterior third of the tongue is usually free or is partially attached to the floor of the mouth by the lingual frenulum. There is a spectrum ranging from fusion of the tongue to the floor of the mouth (ankyloglossia inferiorum) to a lingual frenulum that is short or anchored toward the tip of the tongue (sometimes called tongue tie). Ankyloglossia may be associated with a mild indentation of the tip of the tongue, which should not be coded as a Bifid tongue." ; rdfs:label "Ankyloglossia" ; rdfs:subClassOf obo:HP_0000190, obo:HP_0030809 . obo:HP_0010297 obo:IAO_0000115 "Tongue with a median apical indentation or fork." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:47:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:84557007", "UMLS:C0266111", "UMLS:C4255098" ; oboInOwl:hasExactSynonym "Bifurcated tongue", "Bilobed tongue", "Cleft tongue", "Forked tongue", "Split tongue" ; oboInOwl:hasRelatedSynonym "Snake tongue" ; oboInOwl:id "HP:0010297" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Bifid tongue can be associated with ankyloglossia, but this should be assessed and coded separately. Small indentations of the tip of the tongue should not be coded as a bifid tongue." ; rdfs:label "Bifid tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010298 obo:IAO_0000115 "Glossy appearance of the entire tongue surface." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T11:58:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:9491003", "UMLS:C0155964", "UMLS:C4280381", "UMLS:C4280382", "UMLS:C4280383" ; oboInOwl:hasExactSynonym "Smooth lingual surface", "Smooth surface of tongue", "Smooth tongue" ; oboInOwl:hasNarrowSynonym "Smooth dorsum of tongue" ; oboInOwl:hasRelatedSynonym "Atrophy of dorsum of tongue", "Atrophy of lingual surface", "Atrophy of tongue surface" ; oboInOwl:id "HP:0010298" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is due to reduction in number and/or size of the filiform papillae. A geographic tongue has localized areas of smoothening, but not sufficient to warrant use of the term Smooth tongue." ; rdfs:label "Smooth tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000701 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010299 obo:IAO_0000115 "Any abnormality of dentin." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T12:11:14Z" ; oboInOwl:hasDbXref "UMLS:C4021299" ; oboInOwl:hasExactSynonym "Abnormal dentin", "Abnormality of dentin", "Abnormality of dentine", "Dentin anomaly" ; oboInOwl:id "HP:0010299" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Dentin is a calcified tissue of teeth that is covered by enamel on the crown and cementum on the root and surrounds the entire pulp." ; rdfs:label "Abnormal dentin morphology" ; rdfs:subClassOf obo:HP_0011061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001751 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010300 obo:IAO_0000115 "An abnormal decrease in the pitch of the voice." ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T12:19:22Z" ; oboInOwl:hasDbXref "UMLS:C4023915" ; oboInOwl:hasExactSynonym "Low pitched voice", "Low-pitched voice" ; oboInOwl:id "HP:0010300" ; a owl:Class ; rdfs:label "Abnormally low-pitched voice" ; rdfs:subClassOf obo:HP_5200005 . obo:HP_0010301 obo:IAO_0000115 "A heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T12:58:04Z" ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:253098009", "UMLS:C0027794" ; oboInOwl:hasExactSynonym "Incomplete closure of the vertebral arch" ; oboInOwl:id "HP:0010301" ; a owl:Class ; rdfs:comment "Spinal dysraphism, or neural tube defect comprises a heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life and anomalous development of the caudal cell mass. The anatomic features common to the entire group is an anomaly in the midline structures of the back, especially the absence of some of the neural arches, and defects of the skin, filum terminale, nerves, and spinal cord. Open forms of spinal dysraphism include myelocele, meningocele, and myelomeningocele. These open forms are often associated with hydrocephalus and Arnold-Chiari malformation type II and may be classified as spina bifida aperta. Closed forms of spinal dysraphism includ spina bifida occulta." ; rdfs:label "Spinal dysraphism" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0045005 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010358 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010302 obo:IAO_0000115 "A neoplasm affecting the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T01:05:50Z" ; oboInOwl:hasAlternativeId "HP:0009712" ; oboInOwl:hasDbXref "MSH:D013120", "NCIT:C3262", "SNOMEDCT_US:126962006", "UMLS:C0037930" ; oboInOwl:hasExactSynonym "Spinal cord tumor", "Spinal cord tumour", "Tumor of the spinal cord", "Tumour of the spinal cord" ; oboInOwl:hasRelatedSynonym "Spinal tumor", "Spinal tumors", "Spinal tumour", "Spinal tumours" ; oboInOwl:id "HP:0010302" ; a owl:Class ; rdfs:label "Spinal cord tumor" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0100006 . obo:HP_0010303 obo:IAO_0000115 "Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T01:10:09Z" ; oboInOwl:hasDbXref "UMLS:C4023914" ; oboInOwl:hasExactSynonym "Abnormality of the spinal meninges" ; oboInOwl:id "HP:0010303" ; a owl:Class ; rdfs:label "Abnormal spinal meningeal morphology" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0010651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003292 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010304 obo:IAO_0000115 "An outpouching of the spinal meninges." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T01:11:53Z" ; oboInOwl:hasDbXref "UMLS:C4023913" ; oboInOwl:id "HP:0010304" ; a owl:Class ; rdfs:label "Spinal meningeal diverticulum" ; rdfs:subClassOf obo:HP_0010303 . obo:HP_0010305 obo:IAO_0000115 "Absence (aplasia) of the sacrum." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T01:13:26Z" ; oboInOwl:hasBroadSynonym "Sacrococcygeal agenesis" ; oboInOwl:hasDbXref "MSH:C537221", "SNOMEDCT_US:205425003", "UMLS:C0344490" ; oboInOwl:hasExactSynonym "Absent sacrum", "Sacral agenesis" ; oboInOwl:id "HP:0010305" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absence of the sacrum" ; rdfs:subClassOf obo:HP_0008517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010306 obo:IAO_0000115 "Reduced inferior to superior extent of the thorax." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:13:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249670005", "UMLS:C0426789" ; oboInOwl:hasExactSynonym "Shorter than typical length between neck and abdomen" ; oboInOwl:id "HP:0010306" ; a owl:Class ; rdfs:label "Short thorax" ; rdfs:subClassOf obo:HP_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010307 obo:IAO_0000115 "Stridor is a high pitched sound resulting from turbulent air flow in the upper airway." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:16:48Z" ; oboInOwl:hasBroadSynonym "Noisy breathing" ; oboInOwl:hasDbXref "MSH:D012135", "SNOMEDCT_US:248573009", "SNOMEDCT_US:70407001", "UMLS:C0038450", "UMLS:C0237304" ; oboInOwl:id "HP:0010307" ; a owl:Class ; rdfs:comment "Stridor is different from wheezing by the following reasons. It is louder over the neck than chest wall. Secondly; stridor is mainly inspiratory. If occurs in expiration, it is usually biphasic. On the other hand; wheeze is mainly expiratory and occurs during both phases. It indicates extrathoracic upper-airway obstruction (supraglottic lesions like laryngomalacia, vocal cord lesion) when heard on inspiration. It occurs in expiration if associated with intrathoracic tracheobronchial lesions (tracheomalacia, bronchomalacia, and extrinsic compression). It occurs in both phases if lesion is fixed, for example, stenosis. Stridor is caused by the turbulent flow passing through a narrowed segment of the upper respiratory tract." ; rdfs:label "Stridor" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0010308 obo:IAO_0000115 "The congenital absence of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:21:46Z" ; oboInOwl:hasDbXref "UMLS:C4023912" ; oboInOwl:hasExactSynonym "Aplasia of the sternum", "Breast bone aplasia" ; oboInOwl:id "HP:0010308" ; a owl:Class ; rdfs:label "Asternia" ; rdfs:subClassOf obo:HP_0006714 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010309 obo:IAO_0000115 "The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:23:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:54008006", "UMLS:C0265696" ; oboInOwl:hasExactSynonym "Sternal cleft" ; oboInOwl:id "HP:0010309" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Various degrees of bifid sternum may occur, varying from an enlarged suprasternal notch to complete separation of the two halves of the sternum. Ectopia cordis may or may not accompany this defect in its more severe form." ; rdfs:label "Bifid sternum" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001784 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010310 obo:IAO_0000115 "Accumulation of excessive amounts of lymphatic fluid (chyle) in the pleural cavity." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:30:05Z" ; oboInOwl:hasDbXref "MSH:D002916", "SNOMEDCT_US:83035003", "UMLS:C0008733" ; oboInOwl:id "HP:0010310" ; a owl:Class ; rdfs:label "Chylothorax" ; rdfs:subClassOf obo:HP_0002202 . obo:HP_0010311 obo:IAO_0000115 "Absence or underdevelopment of the breasts." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:31:49Z" ; oboInOwl:hasDbXref "UMLS:C4023911" ; oboInOwl:hasExactSynonym "Absent/small breasts", "Absent/underdeveloped breasts" ; oboInOwl:id "HP:0010311" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the breasts" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010312 obo:IAO_0000115 "The presence of asymmetrical breasts." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:32:46Z" ; oboInOwl:hasDbXref "MSH:C565299", "UMLS:C1854013" ; oboInOwl:id "HP:0010312" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the breasts" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010313 obo:IAO_0000115 "The presence of hypertrophy of the breast." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:34:30Z" ; oboInOwl:hasDbXref "MSH:C536821", "SNOMEDCT_US:372281005", "SNOMEDCT_US:372283008", "SNOMEDCT_US:372285001", "UMLS:C0020565", "UMLS:C0392533", "UMLS:C2225524" ; oboInOwl:hasExactSynonym "Breast enlargement", "Breasts enlarged", "Gigantomastia", "Hypertrophy of the breasts", "Large breast", "Macromastia" ; oboInOwl:id "HP:0010313" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Breast hypertrophy" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010314 obo:IAO_0000115 "Premature development of the breasts." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:36:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:102889008", "UMLS:C0425772" ; oboInOwl:hasExactSynonym "Premature breast development" ; oboInOwl:id "HP:0010314" ; a owl:Class ; rdfs:label "Premature thelarche" ; rdfs:subClassOf obo:HP_0000826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042695 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010315 obo:IAO_0000115 "Absence or underdevelopment of the diaphragm." ; dcterms:creator ; oboInOwl:creation_date "2009-07-12T02:41:58Z" ; oboInOwl:hasDbXref "UMLS:C4023910" ; oboInOwl:hasExactSynonym "Absent/small diaprhagm", "Absent/underdeveloped diaprhagm" ; oboInOwl:id "HP:0010315" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the diaphragm" ; rdfs:subClassOf obo:HP_0000775 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010316 obo:IAO_0000115 "Ebstein's anomaly refers to an abnormally placed and deformed tricuspid valve characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle with a variable degree of malformation and displacement of the anterior leaflet." ; dcterms:creator ; oboInOwl:creation_date "2009-07-14T11:12:07Z" ; oboInOwl:hasAlternativeId "HP:0006674" ; oboInOwl:hasDbXref "EPCC:06.01.34", "ICD-10:Q22.5", "MSH:D004437", "SNOMEDCT_US:204357006", "UMLS:C0013481" ; oboInOwl:hasExactSynonym "Ebstein's anomaly", "Ebstein's anomaly of the tricuspid valve", "Ebstein's malformation" ; oboInOwl:id "HP:0010316" ; a owl:Class ; rdfs:comment "Ebstein's anomaly is often associated with a hypoplastic right ventricle, patent foramen ovale, and a degree of cyanosis dependent on the amount if inadequacy of the tricuspid valve. Ebstein's anomaly may be associated with Wolf-Parkinson-White syndrome or other arrythmias." ; rdfs:label "Ebstein anomaly of the tricuspid valve" ; rdfs:subClassOf obo:HP_0001702 . obo:HP_0010317 obo:IAO_0000115 "Absence of the scapulae." ; dcterms:creator ; oboInOwl:creation_date "2009-07-14T11:40:24Z" ; oboInOwl:hasDbXref "UMLS:C4021298" ; oboInOwl:hasExactSynonym "Absent scapula", "Absent shoulder blade" ; oboInOwl:id "HP:0010317" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Scapular aplasia" ; rdfs:subClassOf obo:HP_0006713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006849 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010318 obo:IAO_0000115 "Absence or underdevelopment of the abdominal musculature." ; dcterms:creator ; oboInOwl:creation_date "2009-07-14T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023909" ; oboInOwl:hasExactSynonym "Absent/small abdominal wall muscles", "Absent/underdeveloped abdominal wall muscles" ; oboInOwl:id "HP:0010318" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the abdominal wall musculature" ; rdfs:subClassOf obo:HP_0010991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010319 obo:IAO_0000115 "An anomaly of the second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:37:12Z" ; oboInOwl:hasDbXref "UMLS:C4023908" ; oboInOwl:hasExactSynonym "Abnormal 2nd toe morphology", "Abnormality of the 2nd toe" ; oboInOwl:id "HP:0010319" ; a owl:Class ; rdfs:label "Abnormal second toe morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010320 obo:IAO_0000115 "An anomaly of the third toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:37:12Z" ; oboInOwl:hasDbXref "UMLS:C4023907" ; oboInOwl:hasExactSynonym "Abnormal 3rd toe morphology", "Abnormality of the 3rd toe" ; oboInOwl:id "HP:0010320" ; a owl:Class ; rdfs:label "Abnormal third toe morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010321 obo:IAO_0000115 "An anomaly of the fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:37:12Z" ; oboInOwl:hasDbXref "UMLS:C4023906" ; oboInOwl:hasExactSynonym "Abnormal 4th toe morphology", "Abnormality of the 4th toe" ; oboInOwl:id "HP:0010321" ; a owl:Class ; rdfs:label "Abnormal fourth toe morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010322 obo:IAO_0000115 "An anomaly of the little toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:37:12Z" ; oboInOwl:hasDbXref "UMLS:C4023905" ; oboInOwl:hasExactSynonym "Abnormal 5th toe morphology", "Abnormality of the 5th toe", "Abnormality of the little toe", "Abnormality of the pinkie toe", "Abnormality of the pinky toe" ; oboInOwl:id "HP:0010322" ; a owl:Class ; rdfs:label "Abnormal fifth toe morphology" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010323 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4023904" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 2nd toe bone" ; oboInOwl:id "HP:0010323" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010324 obo:IAO_0000115 "An anomaly of a phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4023903" ; oboInOwl:hasExactSynonym "Abnormality of the 2nd toe bone" ; oboInOwl:id "HP:0010324" ; a owl:Class ; rdfs:label "Abnormal morphology of phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0010319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010325 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4023902" ; oboInOwl:hasExactSynonym "Absent/small 2nd toe", "Absent/underdeveloped 2nd toe" ; oboInOwl:id "HP:0010325" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 2nd toe" ; rdfs:subClassOf obo:HP_0010319, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010326 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4021297" ; oboInOwl:hasExactSynonym "Displacement of the 2nd toe" ; oboInOwl:id "HP:0010326" ; a owl:Class ; rdfs:label "Deviation of the 2nd toe" ; rdfs:subClassOf obo:HP_0010319, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010327 obo:IAO_0000115 "One or more bent (flexed) joints of the second toe that cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4021296" ; oboInOwl:hasExactSynonym "Joint contractures of the 2nd toe" ; oboInOwl:id "HP:0010327" ; a owl:Class ; rdfs:label "Flexion contracture of the 2nd toe" ; rdfs:subClassOf obo:HP_0005830, obo:HP_0010319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010328 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:18Z" ; oboInOwl:hasDbXref "UMLS:C4023901" ; oboInOwl:id "HP:0010328" ; a owl:Class ; rdfs:label "Polydactyly affecting the 2nd toe" ; rdfs:subClassOf obo:HP_0010112, obo:HP_0010319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003632 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010329 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasDbXref "UMLS:C4023900" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 3rd toe bone" ; oboInOwl:id "HP:0010329" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010320 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010330 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasDbXref "UMLS:C4023899" ; oboInOwl:hasExactSynonym "Abnormality of the bones of the 3rd toe" ; oboInOwl:id "HP:0010330" ; a owl:Class ; rdfs:label "Abnormality of the phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0010320 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010331 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasAlternativeId "HP:0008100" ; oboInOwl:hasDbXref "UMLS:C1862698" ; oboInOwl:hasExactSynonym "Absent/hypoplastic third toe", "Absent/small 3rd toe", "Absent/underdeveloped 3rd toe" ; oboInOwl:id "HP:0010331" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 3rd toe" ; rdfs:subClassOf obo:HP_0010320, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010332 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasDbXref "UMLS:C4021295" ; oboInOwl:hasExactSynonym "Displacement of the 3rd toe" ; oboInOwl:id "HP:0010332" ; a owl:Class ; rdfs:label "Deviation of the 3rd toe" ; rdfs:subClassOf obo:HP_0010320, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010333 obo:IAO_0000115 "One or more bent (flexed) joints of the third toe that cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasDbXref "UMLS:C4021294" ; oboInOwl:hasExactSynonym "Joint contractures of the 3rd toe" ; oboInOwl:id "HP:0010333" ; a owl:Class ; rdfs:label "Flexion contracture of 3rd toe" ; rdfs:subClassOf obo:HP_0005830, obo:HP_0010320 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010334 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:40:52Z" ; oboInOwl:hasDbXref "UMLS:C4023898" ; oboInOwl:id "HP:0010334" ; a owl:Class ; rdfs:label "Polydactyly affecting the 3rd toe" ; rdfs:subClassOf obo:HP_0010112, obo:HP_0010320 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003633 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010335 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023897" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the 4th toe bone" ; oboInOwl:id "HP:0010335" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010336 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023896" ; oboInOwl:id "HP:0010336" ; a owl:Class ; rdfs:label "Abnormality of the phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0010321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010337 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023895" ; oboInOwl:hasExactSynonym "Absent/small 4th toe", "Absent/underdeveloped 4th toe" ; oboInOwl:id "HP:0010337" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 4th toe" ; rdfs:subClassOf obo:HP_0010321, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010338 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4021293" ; oboInOwl:hasExactSynonym "Displacement of the 4th toe" ; oboInOwl:id "HP:0010338" ; a owl:Class ; rdfs:label "Deviation of the 4th toe" ; rdfs:subClassOf obo:HP_0010321, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010339 obo:IAO_0000115 "One or more bent (flexed) joints of the fourth toe that cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4021292" ; oboInOwl:hasExactSynonym "Joint contractures of the 4th toe" ; oboInOwl:id "HP:0010339" ; a owl:Class ; rdfs:label "Flexion contracture of the 4th toe" ; rdfs:subClassOf obo:HP_0005830, obo:HP_0010321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010340 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023894" ; oboInOwl:id "HP:0010340" ; a owl:Class ; rdfs:label "Polydactyly affecting the 4th toe" ; rdfs:subClassOf obo:HP_0010112, obo:HP_0010321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003634 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010341 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:49Z" ; oboInOwl:hasDbXref "UMLS:C4023893" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the little toe bone", "Abnormality of the end part of the pinkie toe bone", "Abnormality of the end part of the pinky toe bone" ; oboInOwl:id "HP:0010341" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010160, obo:HP_0010322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010342 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:49Z" ; oboInOwl:hasDbXref "UMLS:C4023892" ; oboInOwl:hasExactSynonym "Abnormality of the little toe bones", "Abnormality of the pinkie toe bones", "Abnormality of the pinky toe bones" ; oboInOwl:id "HP:0010342" ; a owl:Class ; rdfs:label "Abnormality of the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0010322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010343 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:49Z" ; oboInOwl:hasDbXref "UMLS:C4023891" ; oboInOwl:hasExactSynonym "Absent/small little toe", "Absent/small pinkie toe", "Absent/small pinky toe", "Absent/underdeveloped pinky toe" ; oboInOwl:id "HP:0010343" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the 5th toe" ; rdfs:subClassOf obo:HP_0010322, obo:HP_0010760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010344 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:49Z" ; oboInOwl:hasDbXref "UMLS:C4021291" ; oboInOwl:hasExactSynonym "Displacement of the 5th toe", "Displacement of the little toe", "Displacement of the pinkie toe", "Displacement of the pinky toe" ; oboInOwl:id "HP:0010344" ; a owl:Class ; rdfs:label "Deviation of the 5th toe" ; rdfs:subClassOf obo:HP_0010322, obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010345 obo:IAO_0000115 "One or more bent (flexed) joints of the fifth toe that cannot be straightened actively or passively." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:41:49Z" ; oboInOwl:hasDbXref "UMLS:C4021290" ; oboInOwl:hasExactSynonym "Joint contractures of the 5th toe" ; oboInOwl:id "HP:0010345" ; a owl:Class ; rdfs:label "Flexion contracture of the 5th toe" ; rdfs:subClassOf obo:HP_0005830, obo:HP_0010322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010347 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023890" ; oboInOwl:hasExactSynonym "Absent/small bones of 2nd toe", "Absent/underdeveloped bones of 2nd toe" ; oboInOwl:id "HP:0010347" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010348 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023889" ; oboInOwl:hasExactSynonym "Broad bones of the 2nd toe" ; oboInOwl:id "HP:0010348" ; a owl:Class ; rdfs:label "Broad phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010349 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4021289" ; oboInOwl:hasExactSynonym "Bullet-shaped bones of the 2nd toe", "Bullet-shaped phalanges of the 2nd toe" ; oboInOwl:id "HP:0010349" ; a owl:Class ; rdfs:label "Bullet-shaped 2nd toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010350 obo:IAO_0000115 "A deviation from the normal straight form of one or more phalanges of the second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4021288" ; oboInOwl:hasExactSynonym "Curved bones of the 2nd toe", "Curved phalanges of the 2nd toe" ; oboInOwl:id "HP:0010350" ; a owl:Class ; rdfs:label "Curved 2nd toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010351 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023888" ; oboInOwl:id "HP:0010351" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003641 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010352 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the phalanges of the second toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4021287" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 2nd toe", "Uneven increase in bone density in 2nd toe bone" ; oboInOwl:id "HP:0010352" ; a owl:Class ; rdfs:label "Patchy sclerosis of 2nd toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0010324, obo:HP_0100926 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003641 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010353 obo:IAO_0000115 "Fusion of the interphalangeal joints of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023887" ; oboInOwl:hasExactSynonym "2nd toe symphalangism", "Fused bones of 2nd toe", "Symphalangism affecting the phalanges of the 2nd toe" ; oboInOwl:id "HP:0010353" ; a owl:Class ; rdfs:label "Second toe symphalangism" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010324, obo:HP_0100235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010354 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023886" ; oboInOwl:hasExactSynonym "Triangular shaped bone of 2nd toe", "Triangular shaped bone of second toe" ; oboInOwl:id "HP:0010354" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010355 obo:IAO_0000115 "Partial or complete duplication of a phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4021286" ; oboInOwl:hasExactSynonym "Duplication of the bones of the 2nd toe", "Partial/complete duplication of the phalanges of the 2nd toe" ; oboInOwl:id "HP:0010355" ; a owl:Class ; rdfs:label "Duplication of the phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010181, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010428 obo:HP_0010429 ) ] ] . obo:HP_0010356 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023885" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010356" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010182, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010357 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023884" ; oboInOwl:hasExactSynonym "Abnormality of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0010357" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010183, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010358 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:45:34Z" ; oboInOwl:hasDbXref "UMLS:C4023883" ; oboInOwl:hasExactSynonym "Abnormality of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0010358" ; a owl:Class ; rdfs:label "Abnormal morphology of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010184, obo:HP_0010324 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010359 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023882" ; oboInOwl:hasExactSynonym "Absent/small bones of 3rd toe", "Absent/underdeveloped bones of 3rd toe" ; oboInOwl:id "HP:0010359" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010360 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023881" ; oboInOwl:hasExactSynonym "Wide bones of 3rd toe" ; oboInOwl:id "HP:0010360" ; a owl:Class ; rdfs:label "Broad phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010361 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4021285" ; oboInOwl:hasExactSynonym "Bullet-shaped bones of 3rd toe", "Bullet-shaped phalanges of the 3rd toe" ; oboInOwl:id "HP:0010361" ; a owl:Class ; rdfs:label "Bullet-shaped 3rd toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010362 obo:IAO_0000115 "A deviation from the normal straight form of one or more phalanges of the third toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4021284" ; oboInOwl:hasExactSynonym "Curved bones of 3rd toe", "Curved phalanges of the 3rd toe" ; oboInOwl:id "HP:0010362" ; a owl:Class ; rdfs:label "Curved 3rd toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010363 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4021825" ; oboInOwl:id "HP:0010363" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003642 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010364 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the phalanges of the third toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4021283" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 3rd toe", "Uneven increase in bone density in 3rd toe bone" ; oboInOwl:id "HP:0010364" ; a owl:Class ; rdfs:label "Patchy sclerosis of 3rd toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0010330, obo:HP_0100927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003642 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010365 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023880" ; oboInOwl:hasExactSynonym "Fused bones of 3rd toe" ; oboInOwl:id "HP:0010365" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010330, obo:HP_0100235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010366 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023879" ; oboInOwl:hasExactSynonym "Triangular shaped 3rd toe bones" ; oboInOwl:id "HP:0010366" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010367 obo:IAO_0000115 "Partial or complete duplication of phalanx of third toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4021282" ; oboInOwl:hasExactSynonym "Duplication of 3rd toe bone", "Duplication of phalanx of the third toe", "Partial/complete duplication of the phalanges of the 3rd toe" ; oboInOwl:id "HP:0010367" ; a owl:Class ; rdfs:label "Duplication of phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010181, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010368 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023878" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0010368" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010182, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010369 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023877" ; oboInOwl:hasExactSynonym "Abnormality of the middle bone of 3rd toe" ; oboInOwl:id "HP:0010369" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010183, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010370 obo:IAO_0000115 "An anomaly of the proximal phalanx of third toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:17Z" ; oboInOwl:hasDbXref "UMLS:C4023876" ; oboInOwl:hasExactSynonym "Abnormality of the innermost bone of 3rd toe" ; oboInOwl:id "HP:0010370" ; a owl:Class ; rdfs:label "Abnormal morphology of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010184, obo:HP_0010330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010371 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023875" ; oboInOwl:hasExactSynonym "Absent/small bones of 4th toe", "Absent/underdeveloped bones of 4th toe" ; oboInOwl:id "HP:0010371" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010372 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023874" ; oboInOwl:hasExactSynonym "Broad bones of the 4th toe" ; oboInOwl:id "HP:0010372" ; a owl:Class ; rdfs:label "Broad phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010373 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4021281" ; oboInOwl:hasExactSynonym "Bullet-shaped bones of the 4th toe", "Bullet-shaped phalanges of the 4th toe" ; oboInOwl:id "HP:0010373" ; a owl:Class ; rdfs:label "Bullet-shaped 4th toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010374 obo:IAO_0000115 "A deviation from the normal straight form of one or more phalanges of the fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4021280" ; oboInOwl:hasExactSynonym "Curved bones of 4th toe", "Curved phalanges of the 4th toe" ; oboInOwl:id "HP:0010374" ; a owl:Class ; rdfs:label "Curved 4th toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010375 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023873" ; oboInOwl:id "HP:0010375" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003862 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010376 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the phalanges of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4021279" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 4th toe", "Uneven increase in bone density in 4th toe bone" ; oboInOwl:id "HP:0010376" ; a owl:Class ; rdfs:label "Patchy sclerosis of 4th toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0010336, obo:HP_0100928 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003862 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010377 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023872" ; oboInOwl:hasExactSynonym "Fused bones of 4th toe" ; oboInOwl:id "HP:0010377" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010336, obo:HP_0100235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010378 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023871" ; oboInOwl:hasExactSynonym "Triangular shaped bones of 4th toe" ; oboInOwl:id "HP:0010378" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010379 obo:IAO_0000115 "Partial or complete duplication of phalanx of fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4021278" ; oboInOwl:hasExactSynonym "Duplication of 4th toe bone", "Duplication of phalanx of the fourth toe", "Partial/complete duplication of the phalanges of the 4th toe" ; oboInOwl:id "HP:0010379" ; a owl:Class ; rdfs:label "Duplication of phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010181, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010380 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023870" ; oboInOwl:hasExactSynonym "Abnormality of the outermost 4th toe bone" ; oboInOwl:id "HP:0010380" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010182, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010381 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023869" ; oboInOwl:hasExactSynonym "Abnormality of middle 4th toe bone" ; oboInOwl:id "HP:0010381" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010382 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:51:46Z" ; oboInOwl:hasDbXref "UMLS:C4023868" ; oboInOwl:hasExactSynonym "Abnormal innermost 4th toe bone" ; oboInOwl:id "HP:0010382" ; a owl:Class ; rdfs:label "Abnormal morphology of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010184, obo:HP_0010336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010383 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023867" ; oboInOwl:hasExactSynonym "Absent/small little toe bones", "Absent/small pinkie toe bones", "Absent/small pinky toe bones", "Absent/underdeveloped pinky toe bones" ; oboInOwl:id "HP:0010383" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010173, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010384 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023866" ; oboInOwl:hasExactSynonym "Broad bones of the little toe", "Broad bones of the pinkie toe", "Broad bones of the pinky toe" ; oboInOwl:id "HP:0010384" ; a owl:Class ; rdfs:label "Broad phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010174, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010385 obo:IAO_0000115 "An abnormal morphology of one or more phalanges of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4021277" ; oboInOwl:hasExactSynonym "Bullet-shaped bones of the little toe", "Bullet-shaped bones of the pinkie toe", "Bullet-shaped bones of the pinky toe", "Bullet-shaped phalanges of the 5th toe" ; oboInOwl:id "HP:0010385" ; a owl:Class ; rdfs:label "Bullet-shaped 5th toe phalanx" ; rdfs:subClassOf obo:HP_0010175, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010386 obo:IAO_0000115 "A deviation from the normal straight form of one or more phalanges of the fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4021276" ; oboInOwl:hasExactSynonym "Curved little toe bones", "Curved phalanges of the 5th toe", "Curved pinkie toe bones", "Curved pinky toe bones" ; oboInOwl:id "HP:0010386" ; a owl:Class ; rdfs:label "Curved 5th toe phalanx" ; rdfs:subClassOf obo:HP_0010176, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010387 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023865" ; oboInOwl:id "HP:0010387" ; a owl:Class ; rdfs:label "Osteolytic defects of the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010177, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003863 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010388 obo:IAO_0000115 "Patchy (irregular) increase in bone density of one or more of the phalanges of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4021275" ; oboInOwl:hasExactSynonym "Patchy sclerosis of the phalanges of the 5th toe", "Uneven increase in bone density in little toe bone", "Uneven increase in bone density in pinkie toe bone", "Uneven increase in bone density in pinky toe bone" ; oboInOwl:id "HP:0010388" ; a owl:Class ; rdfs:label "Patchy sclerosis of 5th toe phalanx" ; rdfs:subClassOf obo:HP_0010178, obo:HP_0010342, obo:HP_0100929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003863 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010389 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023864" ; oboInOwl:hasExactSynonym "Fused bones in the little toe", "Fused bones in the pinkie toe", "Fused bones in the pinky toe" ; oboInOwl:id "HP:0010389" ; a owl:Class ; rdfs:label "Symphalangism affecting the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0010342, obo:HP_0100235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010390 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023863" ; oboInOwl:hasExactSynonym "Triangular shaped little toe bone", "Triangular shaped pinkie toe bone", "Triangular shaped pinky toe bone" ; oboInOwl:id "HP:0010390" ; a owl:Class ; rdfs:label "Triangular shaped phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010180, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010391 obo:IAO_0000115 "Partial or complete duplication of one or more phalanx of little toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4020903" ; oboInOwl:hasExactSynonym "Duplication of the bones of the little toe", "Duplication of the bones of the pinkie toe", "Duplication of the bones of the pinky toe", "Duplication of the phalanges of the fifth toe", "Partial/complete duplication of the phalanges of the 5th toe" ; oboInOwl:id "HP:0010391" ; a owl:Class ; rdfs:label "Duplication of the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010181, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010392 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023862" ; oboInOwl:hasExactSynonym "Abnormality of the outermost bone of the little toe", "Abnormality of the outermost bone of the pinkie toe", "Abnormality of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0010392" ; a owl:Class ; rdfs:label "Abnormality of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010393 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023861" ; oboInOwl:hasExactSynonym "Abnormality of the middle bone of the little toe", "Abnormality of the middle bone of the pinkie toe", "Abnormality of the middle bone of the pinky toe" ; oboInOwl:id "HP:0010393" ; a owl:Class ; rdfs:label "Abnormality of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010183, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010394 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:52:18Z" ; oboInOwl:hasDbXref "UMLS:C4023860" ; oboInOwl:hasExactSynonym "Abnormality of the innermost bone of the little toe", "Abnormality of the innermost bone of the pinkie toe", "Abnormality of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0010394" ; a owl:Class ; rdfs:label "Abnormal morphology of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010184, obo:HP_0010342 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010395 obo:IAO_0000115 "Absence (agenesis) or underdevelopment of the proximal phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023859" ; oboInOwl:hasExactSynonym "Absent/small innermost 2nd toe bone", "Absent/underdeveloped innermost 2nd toe bone" ; oboInOwl:id "HP:0010395" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010203, obo:HP_0010325, obo:HP_0010347, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010396 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023858" ; oboInOwl:hasExactSynonym "Broad innermost bone of 2nd toe" ; oboInOwl:id "HP:0010396" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010204, obo:HP_0010348, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010397 obo:IAO_0000115 "An abnormal morphology of the proximal phalanx of the 2nd toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023857" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost bone of 2nd toe" ; oboInOwl:id "HP:0010397" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010205, obo:HP_0010349, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010398 obo:IAO_0000115 "A deviation from the normal straight form of the proximal phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023856" ; oboInOwl:hasExactSynonym "Curved innermost bone of 2nd toe" ; oboInOwl:id "HP:0010398" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010206, obo:HP_0010350, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010399 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023855" ; oboInOwl:id "HP:0010399" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010351, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010400 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023854" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0010400" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010208, obo:HP_0010352, obo:HP_0010358, obo:HP_0100931 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010401 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023853" ; oboInOwl:hasExactSynonym "Fused innermost bone of the 2nd toe" ; oboInOwl:id "HP:0010401" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010353, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010402 dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4023852" ; oboInOwl:hasExactSynonym "Triangular shaped innermost 2nd toe bone" ; oboInOwl:id "HP:0010402" ; a owl:Class ; rdfs:label "Triangular shaped proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010354, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010403 obo:IAO_0000115 "Partial or complete duplication of proximal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T11:58:15Z" ; oboInOwl:hasDbXref "UMLS:C4021274" ; oboInOwl:hasExactSynonym "Duplication of innermost 2nd toe bone", "Duplication of the proximal phalanx of the second toe", "Partial/complete duplication of the proximal phalanx of the 2nd toe" ; oboInOwl:id "HP:0010403" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010355, obo:HP_0010358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010422 obo:HP_0010423 ) ] ] . obo:HP_0010404 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023851" ; oboInOwl:hasExactSynonym "Absent/small middle bone of 2nd toe", "Absent/underdeveloped middle bone of 2nd toe" ; oboInOwl:id "HP:0010404" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010194, obo:HP_0010325, obo:HP_0010347, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010405 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023850" ; oboInOwl:hasExactSynonym "Broad middle bone of 2nd toe" ; oboInOwl:id "HP:0010405" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010195, obo:HP_0010348, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010406 obo:IAO_0000115 "An abnormal morphology of the middle phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023849" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of 2nd toe" ; oboInOwl:id "HP:0010406" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010349, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010407 obo:IAO_0000115 "A deviation from the normal straight form of the middle phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023848" ; oboInOwl:hasExactSynonym "Curved middle bone of 2nd toe" ; oboInOwl:id "HP:0010407" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010197, obo:HP_0010350, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010408 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023847" ; oboInOwl:id "HP:0010408" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010351, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010409 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023846" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the 2nd toe" ; oboInOwl:id "HP:0010409" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010199, obo:HP_0010352, obo:HP_0010357, obo:HP_0100935 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010410 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023845" ; oboInOwl:hasExactSynonym "Fused middle bone of 2nd toe" ; oboInOwl:id "HP:0010410" ; a owl:Class ; rdfs:label "Symphalangism affecting the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010353, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010411 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4023844" ; oboInOwl:hasExactSynonym "Triangular shaped middle bone of 2nd toe" ; oboInOwl:id "HP:0010411" ; a owl:Class ; rdfs:label "Triangular shaped middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010354, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010412 obo:IAO_0000115 "Partial or complete duplication of middle phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4021273" ; oboInOwl:hasExactSynonym "Duplication of middle bone of 2nd toe", "Partial/complete duplication of the middle phalanx of the 2nd toe" ; oboInOwl:id "HP:0010412" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010355, obo:HP_0010357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010426 obo:HP_0010427 ) ] ] . obo:HP_0010413 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023843" ; oboInOwl:hasExactSynonym "Absent/small outermost 2nd toe bone", "Absent/underdeveloped outermost 2nd toe bone" ; oboInOwl:id "HP:0010413" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010185, obo:HP_0010325, obo:HP_0010347, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010414 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023842" ; oboInOwl:hasExactSynonym "Broad outermost bone of the 2nd toe", "Wide outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010414" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010186, obo:HP_0010348, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010415 obo:IAO_0000115 "An abnormal morphology of the distal phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023841" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010415" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010349, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002087 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010416 obo:IAO_0000115 "A deviation from the normal straight form of the distal phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023840" ; oboInOwl:hasExactSynonym "Curved outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010416" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010188, obo:HP_0010350, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010417 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023839" ; oboInOwl:id "HP:0010417" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010351, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0045453 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010418 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023838" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010418" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010190, obo:HP_0010352, obo:HP_0100939 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0010419 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023837" ; oboInOwl:hasExactSynonym "Fused outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010419" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0001859, obo:HP_0010356, obo:HP_0010410 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010420 dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023836" ; oboInOwl:hasExactSynonym "Triangular shaped outermost 2nd toe bone" ; oboInOwl:id "HP:0010420" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010354, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010421 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4021272" ; oboInOwl:hasExactSynonym "Duplication of the outermost bone of the 2nd toe", "Partial/complete duplication of the distal phalanx of the 2nd toe" ; oboInOwl:id "HP:0010421" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010193, obo:HP_0010355, obo:HP_0010356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0010424 obo:HP_0010425 ) ] ] . obo:HP_0010422 obo:IAO_0000115 "Complete duplication of proximal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:56:56Z" ; oboInOwl:hasDbXref "UMLS:C4021271" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost 2nd toe bone", "Complete duplication of the proximal phalanx of the second toe" ; oboInOwl:id "HP:0010422" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010403, obo:HP_0010429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010423 obo:IAO_0000115 "Partial duplication of proximal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:56:56Z" ; oboInOwl:hasDbXref "UMLS:C4021270" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost 2nd toe bone", "Partial duplication of the proximal phalanx of the second toe" ; oboInOwl:id "HP:0010423" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010403, obo:HP_0010428 . obo:HP_0010424 obo:IAO_0000115 "Complete duplication of the distal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:57:27Z" ; oboInOwl:hasDbXref "UMLS:C4023835" ; oboInOwl:hasExactSynonym "Complete duplication of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010424" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010421, obo:HP_0010429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010425 obo:IAO_0000115 "Partial duplication of the distal phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:57:27Z" ; oboInOwl:hasDbXref "UMLS:C4023834" ; oboInOwl:hasExactSynonym "Partial duplication of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010425" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010421, obo:HP_0010428 . obo:HP_0010426 obo:IAO_0000115 "Complete duplication of middle phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4023833" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0010426" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010412, obo:HP_0010429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010427 obo:IAO_0000115 "Partial duplication of middle phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T12:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4023832" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0010427" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010412, obo:HP_0010428 . obo:HP_0010428 obo:IAO_0000115 "Partial duplication of a phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:07:33Z" ; oboInOwl:hasDbXref "UMLS:C4023831" ; oboInOwl:hasExactSynonym "Partial duplication of 2nd toe bone" ; oboInOwl:id "HP:0010428" ; a owl:Class ; rdfs:label "Partial duplication of phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010355 . obo:HP_0010429 obo:IAO_0000115 "Complete duplication of a phalanx of second toe." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:07:33Z" ; oboInOwl:hasDbXref "UMLS:C4023830" ; oboInOwl:hasExactSynonym "Complete duplication of the 2nd toe bones" ; oboInOwl:id "HP:0010429" ; a owl:Class ; rdfs:label "Complete duplication of the phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010355 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010430 dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:27:29Z" ; oboInOwl:hasAlternativeId "HP:0100361" ; oboInOwl:hasDbXref "UMLS:C4023829" ; oboInOwl:hasExactSynonym "Absent 2nd toe bones" ; oboInOwl:id "HP:0010430" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the 2nd toe" ; rdfs:subClassOf obo:HP_0010325, obo:HP_0010347, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010431 obo:IAO_0000115 "Reduced length of one or more phalanx of second toe as a result of developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:27:29Z" ; oboInOwl:hasAlternativeId "HP:0100365" ; oboInOwl:hasDbXref "UMLS:C4021269" ; oboInOwl:hasExactSynonym "Hypoplastic/small phalanges of the 2nd toe", "Short 2nd toe bone", "Short phalanx of the second toe" ; oboInOwl:id "HP:0010431" ; a owl:Class ; rdfs:label "Short phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010325, obo:HP_0010347, obo:HP_0010746 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003641 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010432 obo:IAO_0000115 "Absence of distal phalanx of the second toe as a result of developmental aplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:28:07Z" ; oboInOwl:hasDbXref "UMLS:C4021268" ; oboInOwl:hasExactSynonym "Absent distal phalanx of the second toe", "Absent outermost bone of the 2nd toe", "Aplasia of the distal phalanx of the 2nd toe" ; oboInOwl:id "HP:0010432" ; a owl:Class ; rdfs:label "Absent distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010413, obo:HP_0010430, obo:HP_0010645 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010433 obo:IAO_0000115 "Reduced length of the distal phalanx of the second toe as a result of developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:28:07Z" ; oboInOwl:hasDbXref "UMLS:C4021267" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 2nd toe", "Short distal phalanx of the second toe", "Short outermost bone of the 2nd toe" ; oboInOwl:id "HP:0010433" ; a owl:Class ; rdfs:label "Short distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010413, obo:HP_0010431 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010434 dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:28:48Z" ; oboInOwl:hasDbXref "UMLS:C4023828" ; oboInOwl:hasExactSynonym "Absent middle bone of 2nd toe" ; oboInOwl:id "HP:0010434" ; a owl:Class ; rdfs:label "Aplasia of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010404, obo:HP_0010430, obo:HP_0100388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010435 obo:IAO_0000115 "Reduced length of the middle phalanx of second toe as a result of developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:28:48Z" ; oboInOwl:hasDbXref "UMLS:C4021266" ; oboInOwl:hasExactSynonym "Hypoplastic/small middle phalanx of the 2nd toe", "Short middle 2nd toe bone", "Short middle phalanx of the second toe" ; oboInOwl:id "HP:0010435" ; a owl:Class ; rdfs:label "Short middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010404, obo:HP_0010431 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010436 dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:29:25Z" ; oboInOwl:hasDbXref "UMLS:C4023827" ; oboInOwl:hasExactSynonym "Absent innermost 2nd toe bone" ; oboInOwl:id "HP:0010436" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010395, obo:HP_0010430 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010437 obo:IAO_0000115 "Reduced length of the proximal phalanx of second toe as a result of developmental hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2009-07-16T04:29:25Z" ; oboInOwl:hasDbXref "UMLS:C4021265" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 2nd toe", "Short innermost 2nd toe bone", "Short proximal phalanx of the second toe" ; oboInOwl:id "HP:0010437" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010395, obo:HP_0010431 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010438 obo:IAO_0000115 "A structural abnormality of the interventricular septum." ; dcterms:creator ; oboInOwl:creation_date "2009-07-27T11:59:56Z" ; oboInOwl:hasAlternativeId "HP:0001628" ; oboInOwl:hasDbXref "Fyler:1815", "UMLS:C4021264" ; oboInOwl:hasExactSynonym "Abnormal interventricular septum morphology", "Abnormality of the ventricular septum", "Ventricular septum abnormality" ; oboInOwl:id "HP:0010438" ; a owl:Class ; rdfs:label "Abnormal ventricular septum morphology" ; rdfs:subClassOf obo:HP_0001671, obo:HP_0001713 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010440 obo:IAO_0000115 "In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the fibular side of the foot, next top the little toe), preaxial (on the tibial side of the foot, next to the big toe) or mesoaxial (somewhere central, between big and little toe), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200)." ; dcterms:creator ; oboInOwl:creation_date "2009-07-29T01:23:02Z" ; oboInOwl:hasDbXref "UMLS:C4023826" ; oboInOwl:id "HP:0010440" ; a owl:Class ; rdfs:label "Ectopic accesory toe-like appendage" ; rdfs:subClassOf obo:HP_0001829 . obo:HP_0010441 obo:IAO_0000115 "In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the ulnar side of the hand, next to the little finger), preaxial (on the radial side of the hand, next to the thumb) or mesoaxial (somewhere central, between thumb and little finger), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200)." ; dcterms:creator ; oboInOwl:creation_date "2009-07-29T01:34:47Z" ; oboInOwl:hasDbXref "UMLS:C4023825" ; oboInOwl:id "HP:0010441" ; a owl:Class ; rdfs:label "Ectopic accessory finger-like appendage" ; rdfs:subClassOf obo:HP_0001161 . obo:HP_0010442 obo:IAO_0000115 "A congenital anomaly characterized by the presence of supernumerary fingers or toes." ; dcterms:creator ; oboInOwl:creation_date "2009-07-29T01:39:27Z" ; oboInOwl:hasAlternativeId "HP:0006034", "HP:0006046", "HP:0006123", "HP:0009605" ; oboInOwl:hasDbXref "Fyler:4103", "MSH:D017689", "SNOMEDCT_US:367506006", "UMLS:C0152427" ; oboInOwl:hasExactSynonym "More than five fingers or toes on hands or feet" ; oboInOwl:id "HP:0010442" ; a owl:Class ; rdfs:label "Polydactyly" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010443 obo:IAO_0000115 "A bifid or bifurcated appearance of the femur as seen on x-rays, possible appearing as a more or less severe bowing of the upper leg. Might be associated with hip dysplasia on the affected side." ; dcterms:creator ; oboInOwl:creation_date "2009-07-29T04:29:30Z" ; oboInOwl:hasDbXref "UMLS:C4023824" ; oboInOwl:hasExactSynonym "Notched thighbone", "Split thighbone" ; oboInOwl:id "HP:0010443" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bifid femur" ; rdfs:subClassOf obo:HP_0002823 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010444 obo:IAO_0000115 "The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T09:54:12Z" ; oboInOwl:hasDbXref "MSH:D011665", "SNOMEDCT_US:91434003", "UMLS:C0034088" ; oboInOwl:hasExactSynonym "Pulmonary incompetence", "Pulmonary valve regurgitation", "Pulmonic regurgitation", "Puolmonary valve insufficiency" ; oboInOwl:id "HP:0010444" ; a owl:Class ; rdfs:comment "The pulmonary valve directs blood from the right ventricle (RV) towards the pulmonary arteries during systole." ; rdfs:label "Pulmonary insufficiency" ; rdfs:subClassOf obo:HP_0031654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010445 obo:IAO_0000115 "An ostium primum atrial septal defect is located in the most anterior and inferior aspect of the atrial septum. The ostium primum refers to an anterior and inferior opening (ostium) within the septum primum, which divides the rudimentary atrium during fetal development. The ostium primum is normally sealed by fusion of the superior and inferior endocardial cushions around 5 weeks' gestation. Ostium primum defects result from a failure of the fusion of the embryologic endocardial cushion and septum primum." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T09:59:38Z" ; oboInOwl:hasDbXref "Fyler:1110", "MSH:C536112", "MSH:C548006", "SNOMEDCT_US:253373002", "UMLS:C0344735", "UMLS:C0741296" ; oboInOwl:hasExactSynonym "Atrial septal defect, primum type", "Ostium primum atrial septal defect", "Primum atrioventricular canal defect", "Septum primum defect" ; oboInOwl:id "HP:0010445" ; a owl:Class ; rdfs:label "Primum atrial septal defect" ; rdfs:subClassOf obo:HP_0001631, obo:HP_0006695 . obo:HP_0010446 obo:IAO_0000115 "A narrowing of the orifice of the tricuspid valve of the heart." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:10:10Z" ; oboInOwl:hasDbXref "EPCC:06.01.92", "ICD-10:Q22.4", "MSH:D014264", "SNOMEDCT_US:49915006", "UMLS:C0040963" ; oboInOwl:id "HP:0010446" ; a owl:Class ; rdfs:comment "Tricuspid stenosis results in characteristic changes in the jugular venous pulse in the form of leisurely V to Y descent and prominent a-waves. The liver is enlarged with a firm edge and is pulsatile in presystole. This is best appreciated with one hand on the liver edge and one on the precordium. Auscultation reveals a low- to medium-pitched diastolic rumble with inspiratory accentuation. This is usually localized to the lower sternal border." ; rdfs:label "Tricuspid stenosis" ; rdfs:subClassOf obo:HP_0031651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010447 obo:IAO_0000115 "An abnormal connection between the epithelialised surface of the anal canal and the perianal skin." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:16:39Z" ; oboInOwl:hasDbXref "MEDDRA:10002156", "MSH:D012003", "SNOMEDCT_US:72779005", "UMLS:C0205929" ; oboInOwl:hasExactSynonym "Fistula in ano" ; oboInOwl:id "HP:0010447" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Anal fistula" ; rdfs:subClassOf obo:HP_0034915, obo:HP_0100819 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001245 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010448 obo:IAO_0000115 "A developmental defect resulting in complete obliteration of the lumen of the colon. That is, there is an abnormal closure, or atresia of the tubular structure of the colon." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:23:09Z" ; oboInOwl:hasDbXref "MSH:C562562", "SNOMEDCT_US:37054000", "UMLS:C0266190" ; oboInOwl:hasExactSynonym "Atresia of the large intestine", "Large intestinal atresia" ; oboInOwl:id "HP:0010448" ; a owl:Class ; rdfs:label "Colonic atresia" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0011100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010450 obo:IAO_0000115 "An abnormal narrowing of the lumen of the esophagus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:42:33Z" ; oboInOwl:hasDbXref "MSH:D004940", "SNOMEDCT_US:63305008", "UMLS:C0014866" ; oboInOwl:hasExactSynonym "Narrowing of the esophagus", "Narrowing of the oesophagus" ; oboInOwl:id "HP:0010450" ; a owl:Class ; rdfs:label "Esophageal stenosis" ; rdfs:subClassOf obo:HP_0002031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011566 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010451 obo:IAO_0000115 "Absence or underdevelopment of the spleen." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:48:29Z" ; oboInOwl:hasDbXref "UMLS:C4023823" ; oboInOwl:hasExactSynonym "Absent/small spleen", "Absent/underdeveloped spleen" ; oboInOwl:id "HP:0010451" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the spleen" ; rdfs:subClassOf obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010452 obo:IAO_0000115 "An abnormal (non-anatomic) location of the spleen." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T10:51:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:65146007", "UMLS:C0266632" ; oboInOwl:hasExactSynonym "Abnormal spleen location", "Ectopic spleen" ; oboInOwl:id "HP:0010452" ; a owl:Class ; rdfs:label "Ectopia of the spleen" ; rdfs:subClassOf obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010453 obo:IAO_0000115 "Pelvic asymmetry refers to asymmetric positioning of landmarks on the two sides of the pelvis and may have a structural or functional etiology." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T11:01:50Z" ; oboInOwl:hasBroadSynonym "Pelvic asymmetry" ; oboInOwl:hasDbXref "UMLS:C4021263" ; oboInOwl:hasExactSynonym "Asymmetric pelvis" ; oboInOwl:id "HP:0010453" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pelvic bone asymmetry" ; rdfs:subClassOf obo:HP_0040163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010454 obo:IAO_0000115 "The presence of osteophytes (bone spurs), i.e., of bony projections originating from the acetabulum." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T11:15:40Z" ; oboInOwl:hasDbXref "UMLS:C3808270" ; oboInOwl:id "HP:0010454" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Acetabular spurs" ; rdfs:subClassOf obo:HP_0003170 . obo:HP_0010455 obo:IAO_0000115 "An exaggeration of the normal arched form of the acetabular roof such that it takes on a steep appearance." ; dcterms:creator ; oboInOwl:creation_date "2009-09-14T11:18:20Z" ; oboInOwl:hasDbXref "UMLS:C3150931" ; oboInOwl:id "HP:0010455" ; a owl:Class ; rdfs:label "Steep acetabular roof" ; rdfs:subClassOf obo:HP_0003170 . obo:HP_0010456 obo:IAO_0000115 "An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:14:32Z" ; oboInOwl:hasAlternativeId "HP:0030266" ; oboInOwl:hasDbXref "UMLS:C4023822" ; oboInOwl:hasExactSynonym "Abnormality of greater sciatic notch", "Abnormality of the greater sacrosciatic notch", "Abnormality of the sacroiliac notch" ; oboInOwl:id "HP:0010456" ; a owl:Class ; rdfs:label "Abnormal greater sciatic notch morphology" ; rdfs:subClassOf obo:HP_0002644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010457 obo:IAO_0100001 "HP:0008798" ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:16:32Z" ; oboInOwl:id "HP:0010457" ; a owl:Class ; rdfs:label "obsolete Widening of the sacrosciatic notch" ; owl:deprecated true . obo:HP_0010458 obo:IAO_0000115 "Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In female pseudohermaphroditism, the genotype is female (XX) and the gonads are ovaries, but the external genitalia are virilized." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:21:32Z" ; oboInOwl:hasDbXref "MSH:D058489", "SNOMEDCT_US:8800006", "UMLS:C0238394" ; oboInOwl:id "HP:0010458" ; a owl:Class ; rdfs:label "Female pseudohermaphroditism" ; rdfs:subClassOf obo:HP_0000055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001829 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010459 obo:IAO_0000115 "The presence of both ovarian and testicular tissues either in the same or in opposite gonads. Affected persons have ambiguous genitalia and may have 46,XX or 46,XY karyotypes or 46,XX/XY mosaicism." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:28:15Z" ; oboInOwl:hasAlternativeId "HP:0003242" ; oboInOwl:hasDbXref "MSH:D050090", "SNOMEDCT_US:18978002", "UMLS:C0266361" ; oboInOwl:hasExactSynonym "Testicular and ovarian tissue present" ; oboInOwl:id "HP:0010459" ; a owl:Class ; rdfs:comment "In true hermaphroditism, the testicular tissue must have well developed seminiferous tubules, and the ovarian tissue primordial follicles. The external genitalia are usually associated with variable degrees of sexual ambiguity, depending on the amount of functioning testicular tissue. Internally, a uterus is almost always present, but the development of Mullerian and Wolffian structures is variable and generally depends on the adjacent gonad. Usually there is a vas deferens on the side of the testis, and a Fallopian tube on the side of the ovary. Both types of ducts can occur next to an ovotestis. An ovotestis is the most common gonad found in true hermaphroditism and can be coded with HP:0012861." ; rdfs:label "True hermaphroditism" ; rdfs:subClassOf obo:HP_0000062 . obo:HP_0010460 obo:IAO_0000115 "Abnormality of the female genital system." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:32:09Z" ; oboInOwl:hasDbXref "UMLS:C4023820" ; oboInOwl:id "HP:0010460" ; a owl:Class ; rdfs:comment "Abnormality of the female internal or external genitalia." ; rdfs:label "Abnormality of the female genitalia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010461 obo:IAO_0000115 "Abnormality of the male genital system." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:33:20Z" ; oboInOwl:hasDbXref "UMLS:C4023819" ; oboInOwl:hasExactSynonym "Abnormal male genitals", "Abnormality of the male genitalia" ; oboInOwl:id "HP:0010461" ; a owl:Class ; rdfs:label "Abnormality of the male genitalia" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010462 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the ovary." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:38:35Z" ; oboInOwl:hasDbXref "UMLS:C4023818" ; oboInOwl:hasExactSynonym "Absent/small ovary", "Absent/underdeveloped ovary" ; oboInOwl:id "HP:0010462" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the ovary" ; rdfs:subClassOf obo:HP_0031065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010463 obo:IAO_0000115 "Aplasia, that is failure to develop, of the ovary." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:40:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:12017008", "UMLS:C0266368" ; oboInOwl:hasExactSynonym "Absent ovary" ; oboInOwl:hasRelatedSynonym "Aplasia of the ovaries", "Bilateral absent ovaries" ; oboInOwl:id "HP:0010463" ; a owl:Class ; rdfs:label "Aplasia of the ovary" ; rdfs:subClassOf obo:HP_0010462 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010464 obo:IAO_0000115 "A developmental disorder characterized by the progressive loss of primordial germ cells in the developing ovaries of an embryo, leading to hypoplastic ovaries composed of wavy connective tissue with occasional clumps of granulosa cells, and frequently mesonephric or hilar cells." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:42:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:70550008", "UMLS:C0266371" ; oboInOwl:id "HP:0010464" ; a owl:Class ; rdfs:label "Streak ovary" ; rdfs:subClassOf obo:HP_0008724 . obo:HP_0010465 obo:IAO_0000115 "The onset of puberty before the age of 8 years in girls." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T08:48:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19911007", "UMLS:C0271616" ; oboInOwl:id "HP:0010465" ; a owl:Class ; rdfs:label "Precocious puberty in females" ; rdfs:subClassOf obo:HP_0000826 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046543 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010468 obo:IAO_0000115 "Absence or underdevelopment of the testes." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:28:46Z" ; oboInOwl:hasDbXref "UMLS:C4023817" ; oboInOwl:hasExactSynonym "Absent/small testes", "Absent/underdeveloped testes" ; oboInOwl:id "HP:0010468" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the testes" ; rdfs:subClassOf obo:HP_0045058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010469 obo:IAO_0000115 "Testis not palpable in the scrotum or inguinal canal." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:29:16Z" ; oboInOwl:hasDbXref "UMLS:C4023816" ; oboInOwl:hasExactSynonym "Absence of palpable testicules", "Absent testes", "Aplasia of the testes" ; oboInOwl:id "HP:0010469" ; a owl:Class ; rdfs:comment "Absence can be congenital or not (vanishing testis). Definitive assessment can only be made by imaging or surgical studies, in order to exclude an intra-abdominal testis, which should be coded as Cryptorchidism. True absence of a testis can be difficult to prove. Anorchia is true absence of both testes, and can only be determined by imaging or surgical studies." ; rdfs:label "Absent testis" ; rdfs:subClassOf obo:HP_0010468 . obo:HP_0010470 obo:IAO_0000115 "The presence of more than two testes." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:34:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:17471001", "UMLS:C0266430" ; oboInOwl:hasExactSynonym "Extra testes", "Polyorchidism" ; oboInOwl:id "HP:0010470" ; a owl:Class ; rdfs:label "Supernumerary testes" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010471 obo:IAO_0000115 "Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:48:34Z" ; oboInOwl:hasDbXref "UMLS:C4023815" ; oboInOwl:id "HP:0010471" ; a owl:Class ; rdfs:label "Oligosacchariduria" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_50699 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010472 obo:IAO_0000115 "An abnormality in the synthesis or catabolism of heme. Heme is composed of ferrous iron and protoporphyrin IX and is an essential molecule as the prosthetic group of hemeproteins such as hemoglobin, myoglobin, mitochondrial and microsomal cytochromes." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:53:11Z" ; oboInOwl:hasDbXref "UMLS:C4023814" ; oboInOwl:id "HP:0010472" ; a owl:Class ; rdfs:label "Abnormal circulating porphyrin concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006783 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010473 obo:IAO_0000115 "Abnormally increased excretion of porphyrins in the urine." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T09:57:34Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:44574006", "UMLS:C0151861" ; oboInOwl:id "HP:0010473" ; a owl:Class ; rdfs:comment "Porphyrins are natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure. One of the best-known porphyrins is heme." ; rdfs:label "Porphyrinuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26214 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010474 obo:IAO_0000115 "Buildups of minerals that form in the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:03:20Z" ; oboInOwl:hasDbXref "MSH:D001744", "SNOMEDCT_US:70650003", "UMLS:C0005683" ; oboInOwl:id "HP:0010474" ; a owl:Class ; rdfs:label "Bladder stones" ; rdfs:subClassOf obo:HP_0025487 . obo:HP_0010475 obo:IAO_0000115 "Cloacal exstrophy is a severe anterior abdominal wall defect in which the two hemibladders are visible and are separated by a midline intestinal plate, an omphalocele, and an imperforate anus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:08:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:20815007", "UMLS:C0345217" ; oboInOwl:id "HP:0010475" ; a owl:Class ; rdfs:label "Cloacal exstrophy" ; rdfs:subClassOf obo:HP_0012620, obo:HP_0100548 . obo:HP_0010476 obo:IAO_0000115 "Absence or underdevelopment of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:09:48Z" ; oboInOwl:hasDbXref "UMLS:C4023813" ; oboInOwl:hasExactSynonym "Absent/small bladder", "Absent/underdeveloped bladder" ; oboInOwl:id "HP:0010476" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the bladder" ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010477 obo:IAO_0000115 "Aplasia (absence) of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:10:19Z" ; oboInOwl:hasDbXref "UMLS:C4023812" ; oboInOwl:hasExactSynonym "Absent bladder" ; oboInOwl:id "HP:0010477" ; a owl:Class ; rdfs:label "Aplasia of the bladder" ; rdfs:subClassOf obo:HP_0010476 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010478 obo:IAO_0000115 "Abnormality of the urachus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:13:04Z" ; oboInOwl:hasDbXref "UMLS:C4023811" ; oboInOwl:id "HP:0010478" ; a owl:Class ; rdfs:comment "The urachus is a vestigial embryonic structure, a canal that connects the urinary bladder of the fetus with the allantois (a structure involved in the development of the umbilical cord). During embryonic development, the lumen of the urachus is normally obliterated, transforming the urachus into a solid cord." ; rdfs:label "Abnormality of the urachus" ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010479 obo:IAO_0000115 "Persistence of the urachal canal resulting in a canal between the bladder and the umbilicus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:15:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:398316009", "UMLS:C0266357" ; oboInOwl:hasExactSynonym "Persistent urachus" ; oboInOwl:id "HP:0010479" ; a owl:Class ; rdfs:label "Patent urachus" ; rdfs:subClassOf obo:HP_0010478 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010480 obo:IAO_0000115 "The presence of an abnormal connection between the urethra and another organ or the skin." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:37:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:14981000", "UMLS:C0041970" ; oboInOwl:id "HP:0010480" ; a owl:Class ; rdfs:label "Urethral fistula" ; rdfs:subClassOf obo:HP_0000795, obo:HP_0100589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010481 obo:IAO_0000115 "The presence of an abnormal membrane obstructing the urethra." ; dcterms:creator ; oboInOwl:creation_date "2009-09-15T10:38:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:297163001", "UMLS:C0266345" ; oboInOwl:id "HP:0010481" ; a owl:Class ; rdfs:label "Urethral valve" ; rdfs:subClassOf obo:HP_0000796 . obo:HP_0010482 obo:IAO_0000115 "Shortening of the arms predominantly affecting terminal parts of the arm in relation to the upper and middle limb segments." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T08:56:43Z" ; oboInOwl:hasDbXref "UMLS:C4023810" ; oboInOwl:id "HP:0010482" ; a owl:Class ; rdfs:label "Acromelia of the upper limbs" ; rdfs:subClassOf obo:HP_0010884 . obo:HP_0010483 obo:IAO_0000115 "Amniotic constriction rings affecting the arms." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T09:15:05Z" ; oboInOwl:hasDbXref "UMLS:C4023809" ; oboInOwl:id "HP:0010483" ; a owl:Class ; rdfs:label "Amniotic constriction rings of arms" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0009775 . obo:HP_0010484 obo:IAO_0000115 "Abnormal increase in size of the upper limbs (due to an increase of the size of cells)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T09:23:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:298745009", "UMLS:C0575518" ; oboInOwl:hasExactSynonym "Increased size of upper limb" ; oboInOwl:id "HP:0010484" ; a owl:Class ; rdfs:label "Hypertrophy of the upper limb" ; rdfs:subClassOf obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010485 obo:IAO_0000115 "The ability of the elbow joint to move beyond its normal range of motion." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:05:52Z" ; oboInOwl:hasDbXref "UMLS:C4023808" ; oboInOwl:id "HP:0010485" ; a owl:Class ; rdfs:label "Hyperextensibility at elbow" ; rdfs:subClassOf obo:HP_0001382 . obo:HP_0010486 obo:IAO_0000115 "An abnormality of the hypothenar eminence, i.e., of the muscles on the ulnar side of the palm of the hand (i.e., on the side of the little finger)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:38:43Z" ; oboInOwl:hasDbXref "UMLS:C4023807" ; oboInOwl:id "HP:0010486" ; a owl:Class ; rdfs:label "Abnormality of the hypothenar eminence" ; rdfs:subClassOf obo:HP_0001421 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0017717 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010487 obo:IAO_0000115 "Reduced muscle mass on the ulnar side of the palm, that is, reduction in size of the hypothenar eminence." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:40:18Z" ; oboInOwl:hasAlternativeId "HP:0005721" ; oboInOwl:hasDbXref "UMLS:C1861395" ; oboInOwl:hasExactSynonym "Hypoplasia of the hypothenar eminence", "Hypothenar hypoplasia" ; oboInOwl:id "HP:0010487" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Small hypothenar eminence" ; rdfs:subClassOf obo:HP_0010486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0017717 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010488 obo:IAO_0000115 "Absence or underdevelopment of the palmar creases." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:53:24Z" ; oboInOwl:hasDbXref "UMLS:C4023806" ; oboInOwl:hasExactSynonym "Absent/small palm crease", "Absent/underdeveloped palm crease" ; oboInOwl:id "HP:0010488" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the palmar creases" ; rdfs:subClassOf obo:HP_0010490 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010489 obo:IAO_0000115 "The absence of the major creases of the palm (distal transverse crease, proximal transverse crease, or thenar crease)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:54:09Z" ; oboInOwl:hasDbXref "UMLS:C4021262" ; oboInOwl:hasExactSynonym "Absence of the palmar creases", "Absent palm lines", "Aplasia of the palmar creases" ; oboInOwl:id "HP:0010489" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent palmar crease" ; rdfs:subClassOf obo:HP_0010488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010490 obo:IAO_0000115 "An abnormality of the creases of the skin of palm of hand." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T10:54:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:205557000", "UMLS:C0221199" ; oboInOwl:hasExactSynonym "Abnormality of the palm lines" ; oboInOwl:id "HP:0010490" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormality of the palmar creases" ; rdfs:subClassOf obo:HP_0001018 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0019246 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010491 obo:IAO_0000115 "A narrow segment of significantly reduced circumference of a digit." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T11:08:16Z" ; oboInOwl:hasDbXref "UMLS:C4021261" ; oboInOwl:hasExactSynonym "Amniotic constriction rings of digits" ; oboInOwl:id "HP:0010491" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The description should specify the hand and digit that is affected and the approximate location of the band relative to the phalanges. It may be described as partial, if it does not involve the entire circumference of the digit." ; rdfs:label "Digital constriction ring" ; rdfs:subClassOf obo:HP_0009775 . obo:HP_0010492 obo:IAO_0000115 "Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as \"Symphalangism\"." ; dcterms:creator ; oboInOwl:creation_date "2009-09-16T11:20:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:2560006", "UMLS:C0158736" ; oboInOwl:hasExactSynonym "Osseous syndactyly of the fingers" ; oboInOwl:id "HP:0010492" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Osseous finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 . obo:HP_0010493 obo:IAO_0000115 "An abnormally increased length of the metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T10:25:37Z" ; oboInOwl:hasDbXref "UMLS:C4021260" ; oboInOwl:hasExactSynonym "Elongated long bone of hand", "Increased length of metacarpals" ; oboInOwl:id "HP:0010493" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long metacarpals" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010494 obo:IAO_0000115 "Shortening of the legs predominantly affecting terminal parts of the leg in relation to the upper and middle arm segments." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:04:51Z" ; oboInOwl:hasDbXref "UMLS:C4023805" ; oboInOwl:id "HP:0010494" ; a owl:Class ; rdfs:label "Acromelia of the lower limbs" ; rdfs:subClassOf obo:HP_0006493, obo:HP_0010884 . obo:HP_0010495 obo:IAO_0000115 "Amniotic constriction rings affecting the legs." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:07:10Z" ; oboInOwl:hasDbXref "UMLS:C4023804" ; oboInOwl:id "HP:0010495" ; a owl:Class ; rdfs:label "Amniotic constriction rings of legs" ; rdfs:subClassOf obo:HP_0002814, obo:HP_0009775 . obo:HP_0010496 obo:IAO_0000115 "Abnormal increase in size of the lower limbs (due to an increase of the size of cells)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:08:38Z" ; oboInOwl:hasDbXref "UMLS:C4023803" ; oboInOwl:id "HP:0010496" ; a owl:Class ; rdfs:label "Hypertrophy of the lower limb" ; rdfs:subClassOf obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010497 obo:IAO_0000115 "A developmental defect in which the legs are fused together." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:11:10Z" ; oboInOwl:hasDbXref "MEDDRA:10049216", "MSH:D004480", "SNOMEDCT_US:253191000", "SNOMEDCT_US:67254002", "SNOMEDCT_US:91089008", "UMLS:C0037205" ; oboInOwl:hasRelatedSynonym "Sympodia" ; oboInOwl:id "HP:0010497" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Sirenomelia" ; rdfs:subClassOf obo:HP_0002814 . obo:HP_0010498 obo:IAO_0000115 "A developmental defect that occurs if the two halves of the patella fail to fuse in early childhood." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:39:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:79214007", "UMLS:C0265666" ; oboInOwl:id "HP:0010498" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bipartite patella" ; rdfs:subClassOf obo:HP_0003045 . obo:HP_0010499 obo:IAO_0000115 "The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar subluxation refers to an unstable kneecap that does not slide centrally within its groove, i.e., a partial dislocation of the patella." ; dcterms:creator ; oboInOwl:creation_date "2009-09-17T11:46:41Z" ; oboInOwl:hasDbXref "UMLS:C0857276" ; oboInOwl:hasExactSynonym "Partial knee cap dislocation", "Subluxation of patella" ; oboInOwl:id "HP:0010499" ; a owl:Class ; rdfs:label "Patellar subluxation" ; rdfs:subClassOf obo:HP_0003045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010500 obo:IAO_0000115 "The ability of the knee joint to extend beyond its normal range of motion (the lower leg is moved beyond a straight position with respect to the thigh)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:44:04Z" ; oboInOwl:hasDbXref "UMLS:C4023802" ; oboInOwl:id "HP:0010500" ; a owl:Class ; rdfs:label "Hyperextensibility of the knee" ; rdfs:subClassOf obo:HP_0034670 . obo:HP_0010501 obo:IAO_0000115 "An abnormal limitation of knee joint mobility." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:44:33Z" ; oboInOwl:hasAlternativeId "HP:0005030", "HP:0005192" ; oboInOwl:hasDbXref "UMLS:C4021259" ; oboInOwl:hasExactSynonym "Limitation of knee mobility", "Limited knee movement" ; oboInOwl:id "HP:0010501" ; a owl:Class ; rdfs:comment "The knee permits four types of movement: (i) Extension (straightening the lower leg); (ii) Flexion (bending the knee); (iii) Lateral rotation (turning outwards); and (iv) Medial rotation (turning inward)" ; rdfs:label "Limitation of knee mobility" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0034670 . obo:HP_0010502 obo:IAO_0000115 "A bending or abnormal curvature of the fibula." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:45:18Z" ; oboInOwl:hasDbXref "UMLS:C4023801" ; oboInOwl:hasExactSynonym "Bowed calf bone" ; oboInOwl:id "HP:0010502" ; a owl:Class ; rdfs:comment "A developmental defect with posteromedial fibular angulation." ; rdfs:label "Fibular bowing" ; rdfs:subClassOf obo:HP_0002979, obo:HP_0002991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010503 obo:IAO_0000115 "Duplication of the fibula. This may occur as a part of diplopodia (accessory tarsal or metatarsal bone). Diplopodia with double fibula is an extremely rare condition." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:45:58Z" ; oboInOwl:hasDbXref "UMLS:C3276742" ; oboInOwl:hasExactSynonym "Duplicated calf bone" ; oboInOwl:id "HP:0010503" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fibular duplication" ; rdfs:subClassOf obo:HP_0002991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010504 obo:IAO_0000115 "An abnormal increase in the length of the tibia." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:46:37Z" ; oboInOwl:hasDbXref "UMLS:C4021864" ; oboInOwl:hasExactSynonym "Increased length of shankbone", "Increased length of shinbone" ; oboInOwl:id "HP:0010504" ; a owl:Class ; rdfs:label "Increased length of the tibia" ; rdfs:subClassOf obo:HP_0002992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010505 obo:IAO_0000115 "An abnormal limitation of the mobility of the ankle joint." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:47:11Z" ; oboInOwl:hasDbXref "UMLS:C4023800" ; oboInOwl:id "HP:0010505" ; a owl:Class ; rdfs:label "Limitation of movement at ankles" ; rdfs:subClassOf obo:HP_0001376, obo:HP_0034674 . obo:HP_0010506 obo:IAO_0000115 "An abnormality of dermatoglyphs on the toes and soles, i.e., an abnormality of the patterns of ridges of the skin of sole of foot." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:47:44Z" ; oboInOwl:hasDbXref "UMLS:C4021258" ; oboInOwl:hasExactSynonym "Abnormal dermatoglyphics on feet", "Abnormal prints on feet" ; oboInOwl:id "HP:0010506" ; a owl:Class ; rdfs:label "Abnormal plantar dermatoglyphics" ; rdfs:subClassOf obo:HP_0007477, obo:HP_0100872 . obo:HP_0010507 obo:IAO_0000115 "A difference in size or shape between the left and right foot." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:49:04Z" ; oboInOwl:hasDbXref "UMLS:C4023799" ; oboInOwl:id "HP:0010507" ; a owl:Class ; rdfs:label "Foot asymmetry" ; rdfs:subClassOf obo:HP_0001760 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010508 obo:IAO_0000115 "A condition in which the anterior part of the foot rotates outward away from the midline of the body and the heel remains straight." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T09:59:48Z" ; oboInOwl:hasDbXref "MSH:D000070591", "UMLS:C4082144" ; oboInOwl:id "HP:0010508" ; a owl:Class ; rdfs:label "Metatarsus valgus" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0010509 obo:IAO_0000115 "Absence of the tarsal bones." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T10:05:13Z" ; oboInOwl:hasDbXref "UMLS:C4021257" ; oboInOwl:hasExactSynonym "Absent ankle bone", "Absent tarsals" ; oboInOwl:id "HP:0010509" ; a owl:Class ; rdfs:label "Aplasia of the tarsal bones" ; rdfs:subClassOf obo:HP_0008363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010510 obo:IAO_0000115 "An ability of the toe joints to move beyond their normal range of motion." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T10:15:12Z" ; oboInOwl:hasDbXref "UMLS:C4023798" ; oboInOwl:id "HP:0010510" ; a owl:Class ; rdfs:label "Hypermobility of toe joints" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010511 obo:IAO_0000115 "Toes that appear disproportionately long compared to the foot." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T10:40:43Z" ; oboInOwl:hasDbXref "UMLS:C3150613" ; oboInOwl:hasExactSynonym "Increased length of toes", "Long toe", "Long toes" ; oboInOwl:id "HP:0010511" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding must be distinguished from digits that are thin but of normal length and that of a short mid and hind foot with normal digit lengths. The affected digits should be specified. If only a subset of the digits of a limb is lengthened, the affected digits should be specified." ; rdfs:label "Long toe" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010512 obo:IAO_0000115 "Calcification within the adrenal glands." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T03:34:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:12286000", "UMLS:C0271750" ; oboInOwl:id "HP:0010512" ; a owl:Class ; rdfs:comment "This condition may occur in a wide variety of pathologies, some serious and some with no obvious consequence. Adrenal hemorrhage may be detected as an incidental finding in children in radiographic studies of the abdomen. Etiologies include hemorrhage into the adrenals at or immediately after birth, neuroblastoma, ganglioneuroblastoma, cortical carcinoma, pheochromocytoma, and cysts." ; rdfs:label "Adrenal calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010513 obo:IAO_0000115 "Deposition of calcium salts in the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:09:21Z" ; oboInOwl:hasDbXref "UMLS:C4023797" ; oboInOwl:id "HP:0010513" ; a owl:Class ; rdfs:label "Pituitary calcification" ; rdfs:subClassOf obo:HP_0002514, obo:HP_0011747 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010514 obo:IAO_0000115 "Hypersecretion of one or more pituitary hormones. This can occur in conditions in which deficiency in the target organ leads to decreased hormonal feedback, or as a primary condition most usually in connection with a pituitary adenoma." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:14:54Z" ; oboInOwl:hasDbXref "MSH:D006964", "SNOMEDCT_US:10649000", "UMLS:C0020506" ; oboInOwl:id "HP:0010514" ; a owl:Class ; rdfs:label "Hyperpituitarism" ; rdfs:subClassOf obo:HP_0011747 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0046903 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010515 obo:IAO_0000115 "Absence or underdevelopment of the thymus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:21:24Z" ; oboInOwl:hasDbXref "UMLS:C3278004", "UMLS:C4023796" ; oboInOwl:hasExactSynonym "Absent/small thymus", "Absent/underdeveloped thymus" ; oboInOwl:hasRelatedSynonym "Thymic hypoplasia or aplasia" ; oboInOwl:id "HP:0010515" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the thymus" ; rdfs:subClassOf obo:HP_0000777 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010516 obo:IAO_0000115 "Enlargement of the thymus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:23:10Z" ; oboInOwl:hasDbXref "MSH:D013952", "UMLS:C0040115" ; oboInOwl:hasExactSynonym "Enlarged thymus", "Thymic hyperplasia" ; oboInOwl:id "HP:0010516" ; a owl:Class ; rdfs:label "Thymus hyperplasia" ; rdfs:subClassOf obo:HP_0000777 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002370 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010517 obo:IAO_0000115 "The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:30:35Z" ; oboInOwl:hasDbXref "UMLS:C4023795" ; oboInOwl:hasExactSynonym "Abnormal thymus position" ; oboInOwl:id "HP:0010517" ; a owl:Class ; rdfs:label "Ectopic thymus tissue" ; rdfs:subClassOf obo:HP_0000777 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010518 obo:IAO_0000115 "An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct." ; dcterms:creator ; oboInOwl:creation_date "2009-09-19T04:38:04Z" ; oboInOwl:hasDbXref "MSH:D013955", "SNOMEDCT_US:39462005", "UMLS:C0040124" ; oboInOwl:hasExactSynonym "Thyroglossal duct cyst" ; oboInOwl:id "HP:0010518" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A developmental defect resulting in the presence of a thyroglossal cyst, a fibrous cyst that forms from a persistent thyroglossal duct. During the embryologic development of the thyroid gland, the precursor of the thyroid migrates from the base of the tongue inferiorly though the thyroglossal duct. This duct normally disappears following the development and migration of the thyroid gland, but if a portion of the duct remain it can form a thyroglossal cyst." ; rdfs:label "Thyroglossal cyst" ; rdfs:subClassOf obo:HP_0011772 . obo:HP_0010519 obo:IAO_0000115 "An abnormal increase in quantity or strength of fetal movements." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T10:44:15Z" ; oboInOwl:hasDbXref "UMLS:C4021256" ; oboInOwl:hasExactSynonym "Fetal hyperkinesia", "Foetal hyperkinesia", "Increased foetal movement" ; oboInOwl:id "HP:0010519" ; a owl:Class ; rdfs:label "Increased fetal movement" ; rdfs:subClassOf obo:HP_0001557 . obo:HP_0010521 obo:IAO_0000115 "Gait apraxia affecting the ability to make walking movements with the legs." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:01:35Z" ; oboInOwl:hasDbXref "MSH:D020235", "SNOMEDCT_US:30767006", "UMLS:C1510417" ; oboInOwl:id "HP:0010521" ; a owl:Class ; rdfs:label "Gait apraxia" ; rdfs:subClassOf obo:HP_0001288, obo:HP_0002186 . obo:HP_0010522 obo:IAO_0000115 "A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:19:24Z" ; oboInOwl:hasAlternativeId "HP:0006871" ; oboInOwl:hasDbXref "MSH:D004410", "SNOMEDCT_US:52824009", "SNOMEDCT_US:59770006", "SNOMEDCT_US:9236007", "UMLS:C0476254" ; oboInOwl:hasExactSynonym "Reading disability" ; oboInOwl:id "HP:0010522" ; a owl:Class ; rdfs:label "Dyslexia" ; rdfs:subClassOf obo:HP_0001328 . obo:HP_0010523 obo:IAO_0000115 "An acquired type of sensory aphasia where damage to the brain leads to the loss of the ability to read." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:27:07Z" ; oboInOwl:hasDbXref "MSH:D004410", "SNOMEDCT_US:9236007", "UMLS:C0002018" ; oboInOwl:hasExactSynonym "Text blindness", "Word blindness" ; oboInOwl:id "HP:0010523" ; a owl:Class ; rdfs:comment "Note that dyslexia refers to a developmental reading disability, whereas alexi arefers to an acquired reading disability related to damage to the brain in an individual in whom reading ability had previously been developed." ; rdfs:label "Alexia" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0010524 obo:IAO_0000115 "Inability to recognize objects not because of sensory deficit but because of the inability to combine components of sensory impressions into a complete pattern. Thus, agnosia is a neurological condition which results in an inability to know, to name, to identify, and to extract meaning from visual, auditory, or tactile impressions." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:33:03Z" ; oboInOwl:hasDbXref "MSH:D000377", "SNOMEDCT_US:42341009", "UMLS:C0001816" ; oboInOwl:id "HP:0010524" ; a owl:Class ; rdfs:label "Agnosia" ; rdfs:subClassOf obo:HP_0011446 . obo:HP_0010525 obo:IAO_0000115 "An inability or difficulty differentiating among the fingers of either hand as well as the hands of others." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:37:33Z" ; oboInOwl:hasDbXref "MSH:D000377", "SNOMEDCT_US:3449007", "UMLS:C0234509" ; oboInOwl:id "HP:0010525" ; a owl:Class ; rdfs:label "Finger agnosia" ; rdfs:subClassOf obo:HP_0010524 . obo:HP_0010526 obo:IAO_0000115 "A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:40:43Z" ; oboInOwl:hasDbXref "MSH:D000381", "SNOMEDCT_US:88278002", "UMLS:C0234144" ; oboInOwl:id "HP:0010526" ; a owl:Class ; rdfs:label "Dysgraphia" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0010527 obo:IAO_0000115 "Inability to recognize the form of objects by touch without visual input. That is, an impairment in the recognition of objects based only on the texture, size, weight and three-dimensional form of the object in the absence of any major somatosensory deficit." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:41:58Z" ; oboInOwl:hasDbXref "MSH:D000377", "SNOMEDCT_US:25094008", "UMLS:C0234505" ; oboInOwl:hasExactSynonym "Astereognosis", "Somatosensory agnosia" ; oboInOwl:id "HP:0010527" ; a owl:Class ; rdfs:label "Astereognosia" ; rdfs:subClassOf obo:HP_0010524, obo:HP_0011730 . obo:HP_0010528 obo:IAO_0000115 "Inability to recognize faces of familiar persons." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T11:45:49Z" ; oboInOwl:hasDbXref "MSH:D020238", "SNOMEDCT_US:18358003", "UMLS:C0234512" ; oboInOwl:hasExactSynonym "Face blindness", "Facial agnosia" ; oboInOwl:id "HP:0010528" ; a owl:Class ; rdfs:label "Prosopagnosia" ; rdfs:subClassOf obo:HP_0010524 . obo:HP_0010529 obo:IAO_0000115 "The repetition of words or phrases that are odd or used in a nonsocial manner. These can be words or phrases the person has heard or invented." ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T08:17:27Z" ; oboInOwl:hasDbXref "MSH:D004454", "SNOMEDCT_US:64712007", "UMLS:C0013528", "UMLS:C4280380" ; oboInOwl:hasExactSynonym "Echoing another person's speech", "Echologia", "Echophrasia", "Repeated speech" ; oboInOwl:id "HP:0010529" ; a owl:Class ; rdfs:label "Echolalia" ; rdfs:subClassOf obo:HP_4000072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010530 obo:IAO_0000115 "Palatal tremor (PT) is an involuntary, rhythmic and oscillatory movement of the soft palate. PT is a rare type of tremor involving the soft palate. It can be unilateral or bilateral." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T08:50:17Z" ; oboInOwl:hasDbXref "MSH:D009207", "SNOMEDCT_US:9366002", "UMLS:C0030214" ; oboInOwl:hasExactSynonym "Palatal myoclonus" ; oboInOwl:id "HP:0010530" ; a owl:Class ; rdfs:comment "Previously, PT was known as palatal myoclonus but it was subsequently renamed palatal tremor during the First International Congress of Movement Disorders to acknowledge the continuous and rhythmic nature of the palatal movement. Palatal tremors do not oscillate around a point, unlike any other type of tremor. Palatal tremors can have huge variability in frequency, unlike other commonly-described tremors." ; rdfs:label "Palatal tremor" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0010531 obo:IAO_0000115 "Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T08:53:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:698836007", "UMLS:C3697670" ; oboInOwl:id "HP:0010531" ; a owl:Class ; rdfs:label "Spinal myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0010532 obo:IAO_0000115 "Paroxysmal episodes of vertigo." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T09:12:15Z" ; oboInOwl:hasDbXref "MSH:D014717", "SNOMEDCT_US:103290003", "UMLS:C0522357" ; oboInOwl:id "HP:0010532" ; a owl:Class ; rdfs:label "Paroxysmal vertigo" ; rdfs:subClassOf obo:HP_0002321 . obo:HP_0010533 obo:IAO_0000115 "The combination of pendular nystagmus, head nodding, and torticollis." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T09:19:57Z" ; oboInOwl:hasDbXref "MSH:D013036", "SNOMEDCT_US:18191000", "UMLS:C0546878" ; oboInOwl:id "HP:0010533" ; a owl:Class ; rdfs:label "Spasmus nutans" ; rdfs:subClassOf obo:HP_0012043 . obo:HP_0010534 obo:IAO_0000115 "A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information." ; dcterms:creator ; oboInOwl:creation_date "2009-09-20T09:33:50Z" ; oboInOwl:hasDbXref "MSH:D020236", "SNOMEDCT_US:230736007", "UMLS:C0338591" ; oboInOwl:id "HP:0010534" ; a owl:Class ; rdfs:label "Transient global amnesia" ; rdfs:subClassOf obo:HP_0002354 . obo:HP_0010535 obo:IAO_0000115 "An intermittent cessation of airflow at the mouth and nose during sleep. Apneas of at least 10 seconds are considered important, but persons with sleep apnea may have apneas of 20 seconds to up to 2 or 3 minutes. Patients may have up to 15 events per hour of sleep." ; dcterms:creator ; oboInOwl:creation_date "2009-09-21T08:53:35Z" ; oboInOwl:hasDbXref "MSH:D012891", "SNOMEDCT_US:73430006", "UMLS:C0037315" ; oboInOwl:hasExactSynonym "Pauses in breathing while sleeping", "Sleep apnoea" ; oboInOwl:id "HP:0010535" ; a owl:Class ; rdfs:label "Sleep apnea" ; rdfs:subClassOf obo:HP_0002104, obo:HP_0002360 . obo:HP_0010536 obo:IAO_0000115 "Sleep apnea resulting from a transient abolition of the central drive to the ventilatory muscles." ; dcterms:creator ; oboInOwl:creation_date "2009-09-21T08:57:02Z" ; oboInOwl:hasDbXref "MSH:D020182", "UMLS:C0520680" ; oboInOwl:hasExactSynonym "Central sleep apnoea" ; oboInOwl:id "HP:0010536" ; a owl:Class ; rdfs:label "Central sleep apnea" ; rdfs:subClassOf obo:HP_0010535 . obo:HP_0010537 obo:IAO_0000115 "An abnormally increased width of the cranial sutures for age-related norms (generally resulting from delayed closure)." ; dcterms:creator ; oboInOwl:creation_date "2009-09-21T09:50:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:268855009", "UMLS:C0410935" ; oboInOwl:hasExactSynonym "Broad cranial sutures", "Large cranial suture", "Persistent open cranial sutures", "Widened cranial sutures", "open cranial sutures" ; oboInOwl:id "HP:0010537" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Wide cranial sutures" ; rdfs:subClassOf obo:HP_0011329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003685 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010538 obo:IAO_0000115 "An abnormally small sella turcica." ; dcterms:creator ; oboInOwl:creation_date "2009-09-21T10:19:05Z" ; oboInOwl:hasDbXref "UMLS:C4023794", "UMLS:C4072875", "UMLS:C4072876" ; oboInOwl:hasExactSynonym "Hypoplasia of sella turcica" ; oboInOwl:hasNarrowSynonym "Hypoplasia of hypophseal fossa", "Hypoplasia of pituitary fossa", "Small hypophyseal fossa", "Small pituitary fossa" ; oboInOwl:id "HP:0010538" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Small sella turcica" ; rdfs:subClassOf obo:HP_0002679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010539 obo:IAO_0000115 "The presence of an abnormally thin calvarium." ; dcterms:creator ; oboInOwl:creation_date "2009-09-21T10:21:29Z" ; oboInOwl:hasBroadSynonym "Thin skull bone" ; oboInOwl:hasDbXref "UMLS:C1856231", "UMLS:C4280379" ; oboInOwl:hasExactSynonym "Thin cranial bone" ; oboInOwl:id "HP:0010539" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thin calvarium" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004339 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010540 obo:IAO_0000115 "A degree of pneumatization that is increased compared to age-related norms." ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:04:21Z" ; oboInOwl:hasDbXref "UMLS:C4023793" ; oboInOwl:id "HP:0010540" ; a owl:Class ; rdfs:label "Advanced pneumatization of cranial sinuses" ; rdfs:subClassOf obo:HP_0000245 . obo:HP_0010541 obo:IAO_0000115 "The presence of convoluted folds and furrows formed from thickened skin of the scalp, resembling cerebriform pattern. The scalp has convoluted and elevated folds, 1 to 2 cm in thickness. The convolutions generally cannot be flattened by traction." ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:15:33Z" ; oboInOwl:hasBroadSynonym "Scalp folds", "Scalp furrows" ; oboInOwl:hasDbXref "SNOMEDCT_US:51603000", "UMLS:C0263417", "UMLS:C4072877", "UMLS:C4280378" ; oboInOwl:hasExactSynonym "Cutis verticis gyrata", "Furrows in thickened skin on top of scalp", "Scalp rugae", "Thickened folds on top of scalp" ; oboInOwl:hasRelatedSynonym "Thickening of the scalp" ; oboInOwl:id "HP:0010541" ; a owl:Class ; rdfs:label "Cutis gyrata of scalp" ; rdfs:subClassOf obo:HP_0001965, obo:HP_0011356 . obo:HP_0010542 obo:IAO_0000115 "Nystagmus due to disturbance of the vestibular system; eye movements are rhythmic, with slow and fast components." ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:38:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46888001", "UMLS:C0155379" ; oboInOwl:id "HP:0010542" ; a owl:Class ; rdfs:label "Vestibular nystagmus" ; rdfs:subClassOf obo:HP_0000639, obo:HP_0009591 . obo:HP_0010543 obo:IAO_0000115 "Bursts of large-amplitude multidirectional saccades without intersaccadic interval" ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:40:51Z" ; oboInOwl:hasDbXref "MSH:D015835", "SNOMEDCT_US:194177006", "UMLS:C0242567" ; oboInOwl:id "HP:0010543" ; a owl:Class ; rdfs:comment "Spontaneous, non-rhythmic, multi-directional, chaotic movements of the eyes, giving the appearance of agitation. There may be bursts of conjugate movement of the eyes in varying directions and of varying amplitude." ; rdfs:label "Opsoclonus" ; rdfs:subClassOf obo:HP_0012547, obo:HP_0032104 . obo:HP_0010544 obo:IAO_0000115 "Vertical nystagmus may present with either up-beating or down-beating eye movements or both. When present in the straight-ahead position of gaze it is referred to as upbeat nystagmus or downbeat nystagmus." ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:45:18Z" ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:111533001", "UMLS:C0271386" ; oboInOwl:id "HP:0010544" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vertical nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0010545 obo:IAO_0000115 "Downbeat nystagmus is a type of fixation nystagmus with the fast phase beating in a downward direction. It generally increases when looking to the side and down and when lying prone." ; dcterms:creator ; oboInOwl:creation_date "2009-09-23T10:47:44Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:307676006", "UMLS:C0585544" ; oboInOwl:id "HP:0010545" ; a owl:Class ; rdfs:label "Downbeat nystagmus" ; rdfs:subClassOf obo:HP_0010544 . obo:HP_0010546 obo:IAO_0000115 "Fine, rapid twitching of individual muscle fibers with little or no movement of the muscle as a whole. If a motor neuron or its axon is destroyed, the muscle fibers it innervates undergo denervation atrophy. This leads to hypersensitivity of individual muscle fibers to acetyl choline so that they may contract spontaneously. Isolated activity of individual muscle fibers is generally so fine it cannot be seen through the intact skin, although it can be recorded as a short-duration spike in the EMG." ; dcterms:creator ; oboInOwl:creation_date "2009-09-29T08:23:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:41405005", "UMLS:C0231531" ; oboInOwl:hasExactSynonym "EMG: fibrillations on electromyogram" ; oboInOwl:hasRelatedSynonym "Twitching" ; oboInOwl:id "HP:0010546" ; a owl:Class ; rdfs:label "Muscle fibrillation" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0010547 obo:IAO_0000115 "A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation." ; dcterms:creator ; oboInOwl:creation_date "2009-09-29T09:21:45Z" ; oboInOwl:hasDbXref "MSH:D009123", "SNOMEDCT_US:186611004", "SNOMEDCT_US:397488002", "UMLS:C0026825" ; oboInOwl:id "HP:0010547" ; a owl:Class ; rdfs:label "Muscle flaccidity" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0010548 obo:IAO_0000115 "A localized myotonic contraction in a muscle in reaction to percussion (tapping with the examiner's finger, a rubber percussion hammer, or a similar object)." ; dcterms:creator ; oboInOwl:creation_date "2009-10-01T08:15:50Z" ; oboInOwl:hasAlternativeId "HP:0004304" ; oboInOwl:hasDbXref "MSH:D009222", "UMLS:C0751359" ; oboInOwl:hasExactSynonym "Transient swelling of muscle induced by percussion" ; oboInOwl:id "HP:0010548" ; a owl:Class ; rdfs:label "Percussion myotonia" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0010549 obo:IAO_0000115 "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons." ; dcterms:creator ; oboInOwl:creation_date "2009-10-01T08:30:25Z" ; oboInOwl:hasDbXref "UMLS:C4021255" ; oboInOwl:hasExactSynonym "Paralysis due to lesions of the principle motor tracts" ; oboInOwl:id "HP:0010549" ; a owl:Class ; rdfs:label "Weakness due to upper motor neuron dysfunction" ; rdfs:subClassOf obo:HP_0002493 . obo:HP_0010550 obo:IAO_0000115 "Severe or complete weakness of both lower extremities with sparing of the upper extremities." ; dcterms:creator ; oboInOwl:creation_date "2009-10-01T08:32:57Z" ; oboInOwl:hasDbXref "MSH:D010264", "SNOMEDCT_US:60389000", "UMLS:C0030486" ; oboInOwl:hasExactSynonym "Leg paralysis" ; oboInOwl:id "HP:0010550" ; a owl:Class ; rdfs:label "Paraplegia" ; rdfs:subClassOf obo:HP_0010551 . obo:HP_0010551 obo:IAO_0000115 "Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength." ; dcterms:creator ; oboInOwl:creation_date "2009-10-01T08:36:05Z" ; oboInOwl:hasDbXref "UMLS:C4023792" ; oboInOwl:id "HP:0010551" ; a owl:Class ; rdfs:label "Paraplegia/paraparesis" ; rdfs:subClassOf obo:HP_0010549 . obo:HP_0010553 obo:IAO_0000115 "An acute dystonic reaction with blepharospasm, periorbital twitches, and protracted fixed staring episodes. There may be a maximal upward deviation of the eyes in the sustained fashion. Oculogyric crisis can be triggered by a number of factors including neuroleptic medications." ; dcterms:creator ; oboInOwl:creation_date "2009-10-01T08:56:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:5332004", "UMLS:C0085637" ; oboInOwl:id "HP:0010553" ; a owl:Class ; rdfs:label "Oculogyric crisis" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0010554 obo:IAO_0000115 "A soft tissue continuity in the A/P axis between two fingers that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two fingers that lies significantly distal to the flexion crease that overlies the metacarpophalangeal joint of the adjacent fingers." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-07T10:59:57Z" ; oboInOwl:hasAlternativeId "HP:0001214", "HP:0005637", "HP:0006054", "HP:0006220" ; oboInOwl:hasDbXref "UMLS:C4021254" ; oboInOwl:hasExactSynonym "Cutaneous syndactyly of fingers", "Cutaneous syndactyly of hands", "Webbed fingers", "Webbed skin of fingers" ; oboInOwl:id "HP:0010554" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "We have set an arguably arbitrary threshold to distinguish the object form the subjective finding. While severe degrees of cutaneous syndactyly are clearly objective, more subtle degrees are subjective. We set this threshold to distinguish these two situations. The digits (or parts of) are joined together by tissue that is not normally present between the digits at that point in the P/D axis. A modifier of \"complete\" may be used if the cutaneous syndactyly extends to the distal end of the nail bed of the digits. The affected digits should be specified. Note that the unqualified term \"syndactyly\" is no longer allowed as it is unclear whether this refers to bony or cutaneous syndactyly." ; rdfs:label "Cutaneous finger syndactyly" ; rdfs:subClassOf obo:HP_0006101, obo:HP_0012725 . obo:HP_0010557 obo:IAO_0000115 "A finger resting on the dorsal surface of an adjacent digit when the hand is at rest." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-13T09:21:52Z" ; oboInOwl:hasDbXref "UMLS:C1446712" ; oboInOwl:id "HP:0010557" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Overlapping of the fingers occurring as the result of a deviation of the fingers from their normal position. Fingers that are laterally deviated, but do not rest on top of adjacent fingers should be coded as Clinodactyly." ; rdfs:label "Overlapping fingers" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001590 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010558 obo:IAO_0000115 "An abnormality of the clivus, which is the inclined bony region of the posterior cranial fossa located between the sella turcica and the foramen magnum." ; dcterms:creator ; oboInOwl:creation_date "2009-10-14T09:37:19Z" ; oboInOwl:hasDbXref "UMLS:C4023791" ; oboInOwl:id "HP:0010558" ; a owl:Class ; rdfs:label "Abnormality of the clivus" ; rdfs:subClassOf obo:HP_0000932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004108 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010559 obo:IAO_0000115 "An abnormal vertical orientation of the clivus (which normally forms a kind of slope from the sella turcica down to the region of the foramen magnum)." ; dcterms:creator ; oboInOwl:creation_date "2009-10-14T09:39:04Z" ; oboInOwl:hasDbXref "UMLS:C1844702" ; oboInOwl:id "HP:0010559" ; a owl:Class ; rdfs:label "Vertical clivus" ; rdfs:subClassOf obo:HP_0010558 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001854 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004108 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010560 obo:IAO_0000115 "An abnormally wavy surface or edge of the clavicles." ; dcterms:creator ; oboInOwl:creation_date "2009-10-14T09:52:46Z" ; oboInOwl:hasDbXref "UMLS:C4021253" ; oboInOwl:hasExactSynonym "Wavy clavicles", "Wavy collarbone" ; oboInOwl:id "HP:0010560" ; a owl:Class ; rdfs:label "Undulate clavicles" ; rdfs:subClassOf obo:HP_0000889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000967 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010561 obo:IAO_0000115 "An abnormally wavy surface or edge of the ribs." ; dcterms:creator ; oboInOwl:creation_date "2009-10-14T09:56:07Z" ; oboInOwl:hasDbXref "UMLS:C1969185" ; oboInOwl:hasExactSynonym "Wavy ribs" ; oboInOwl:id "HP:0010561" ; a owl:Class ; rdfs:label "Undulate ribs" ; rdfs:subClassOf obo:HP_0000772 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000967 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010562 dcterms:creator ; oboInOwl:creation_date "2009-10-15T07:39:56Z" ; oboInOwl:hasDbXref "MEDDRA:10023330", "MSH:D007627", "SNOMEDCT_US:33659008", "SNOMEDCT_US:58405006", "UMLS:C0022548" ; oboInOwl:id "HP:0010562" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Keloids" ; rdfs:subClassOf obo:HP_0000987 . obo:HP_0010564 obo:IAO_0000115 "A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-16T02:20:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:232412004", "UMLS:C0339864" ; oboInOwl:id "HP:0010564" ; a owl:Class ; rdfs:label "Bifid epiglottis" ; rdfs:subClassOf obo:HP_0005483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010565 obo:IAO_0000115 "This term applies if the Epiglottis is absent or hypoplastic." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-16T02:27:31Z" ; oboInOwl:hasDbXref "UMLS:C4023790" ; oboInOwl:id "HP:0010565" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the Epiglottis" ; rdfs:subClassOf obo:HP_0005483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010566 obo:IAO_0000115 "A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-16T02:51:16Z" ; oboInOwl:hasDbXref "MSH:D006222", "SNOMEDCT_US:400006008", "SNOMEDCT_US:51398009", "UMLS:C0018552" ; oboInOwl:id "HP:0010566" ; a owl:Class ; rdfs:label "Hamartoma" ; rdfs:subClassOf obo:HP_0011792 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_74 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010567 obo:IAO_0000115 "Y-shaped metatarsals are the result of a partial fusion of two metatarsal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metatarsals may be seen in combination with polydactyly." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-16T06:50:11Z" ; oboInOwl:hasDbXref "UMLS:C4023789" ; oboInOwl:hasExactSynonym "Y-shaped long bone of foot" ; oboInOwl:id "HP:0010567" ; a owl:Class ; rdfs:label "Y-shaped metatarsals" ; rdfs:subClassOf obo:HP_0001832 . obo:HP_0010568 obo:IAO_0000115 "A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the eye." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-17T12:57:24Z" ; oboInOwl:hasDbXref "UMLS:C4023788" ; oboInOwl:id "HP:0010568" ; a owl:Class ; rdfs:label "Hamartoma of the eye" ; rdfs:subClassOf obo:HP_0030670, obo:HP_0100012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010569 obo:IAO_0000115 "Concentration of 7-dehydrocholesterol in the blood circulation above the upper limit of normal." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-19T08:49:58Z" ; oboInOwl:hasDbXref "UMLS:C1849185" ; oboInOwl:hasExactSynonym "Elevated levels of cholesta-5,7-dien-3beta-ol" ; oboInOwl:id "HP:0010569" ; a owl:Class ; rdfs:comment "Elevated 7-dehydrocholesterol levels occur as the result of a deficiency of the enzyme delta-7-sterol reductase, the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. Homozygous mutations in the gene encoding for this enzyme are the molecular genetic cause of Smith-Lemli-Opitz Syndrome." ; rdfs:label "Elevated circulating 7-dehydrocholesterol concentration" ; rdfs:subClassOf obo:HP_0034934 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17759 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010570 obo:IAO_0000115 "An abnormally low concentration of serum alpha-fetoprotein as compared to normal values for gestational-age." ; dcterms:creator ; oboInOwl:creation_date "2009-10-20T07:01:24Z" ; oboInOwl:hasDbXref "UMLS:C4023787" ; oboInOwl:hasExactSynonym "Low maternal serum alpha-fetoprotein" ; oboInOwl:id "HP:0010570" ; a owl:Class ; rdfs:comment "Reduced levels of alpha-fetoprotein can be seen in some fetal disorders such as Down syndrome." ; rdfs:label "Low maternal circulating alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0010571 obo:IAO_0000115 "An abnormal elevation of phytanic acid." ; dcterms:creator ; oboInOwl:creation_date "2009-10-20T07:19:29Z" ; oboInOwl:hasDbXref "UMLS:C4023786" ; oboInOwl:hasExactSynonym "Elevated level of phytanic acid", "Elevated levels of phytanic acid" ; oboInOwl:id "HP:0010571" ; a owl:Class ; rdfs:comment "Phytanic acid (3,7,11,15-tetramethyl hexadecanoic acid) is a fatty acid that is derived from chlorophyll and present in the diet. The metabolism of phytanic acid involves alpha-oxidation in the peroxisome, which converts phytanic acid to pristanic acid. Peroxisomes involved in the catabolism of very long chain fatty acids and phytanic acid. Peroxisomal malfunctioning can lead to over-accumulation of very long chain fatty acids and phytanic acid, among other things." ; rdfs:label "Elevated circulating phytanic acid concentration" ; rdfs:subClassOf obo:HP_0010965 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010574 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the femur." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-21T01:28:23Z" ; oboInOwl:hasAlternativeId "HP:0010589" ; oboInOwl:hasDbXref "UMLS:C4021252" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost thighbone", "Abnormality of the proximal femoral epiphysis" ; oboInOwl:id "HP:0010574" ; a owl:Class ; rdfs:comment "Note that the proximal epiphysis of the femur is often referred to as the capital femoral epiphysis from the Latin word caput for head." ; rdfs:label "Abnormality of the epiphysis of the femoral head" ; rdfs:subClassOf obo:HP_0003368, obo:HP_0006499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006767 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010575 obo:IAO_0000115 "The presence of developmental dysplasia of the femoral head." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-21T01:30:40Z" ; oboInOwl:hasBroadSynonym "Abnormality of femoral head development" ; oboInOwl:hasDbXref "UMLS:C4021251", "UMLS:C4280377" ; oboInOwl:hasExactSynonym "Dysplastic femoral head" ; oboInOwl:id "HP:0010575" ; a owl:Class ; rdfs:label "Dysplasia of the femoral head" ; rdfs:subClassOf obo:HP_0003368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010576 obo:IAO_0000115 "A cystic lesion originating within the brain." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T01:38:49Z" ; oboInOwl:hasDbXref "UMLS:C4021250" ; oboInOwl:hasExactSynonym "Cerebral cystic malformation" ; oboInOwl:id "HP:0010576" ; a owl:Class ; rdfs:label "Intracranial cystic lesion" ; rdfs:subClassOf obo:HP_0030724 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010577 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "UMLS:C4021862" ; oboInOwl:hasExactSynonym "Absent end part of bone" ; oboInOwl:id "HP:0010577" ; a owl:Class ; rdfs:label "Absent epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010578 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "UMLS:C4023785" ; oboInOwl:hasExactSynonym "Bracket shaped end part of long bone" ; oboInOwl:id "HP:0010578" ; a owl:Class ; rdfs:label "Bracket epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010579 obo:IAO_0000115 "Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasAlternativeId "HP:0000937", "HP:0006078" ; oboInOwl:hasDbXref "UMLS:C1865037" ; oboInOwl:hasExactSynonym "Cone-shaped end part of bone", "Cone-shaped epiphyses", "Coned epiphyses" ; oboInOwl:id "HP:0010579" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010580 obo:IAO_0000115 "Increased size of epiphyses." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasAlternativeId "HP:0003018", "HP:0003055", "HP:0005082" ; oboInOwl:hasDbXref "UMLS:C1833328" ; oboInOwl:hasExactSynonym "Large end part of bone", "Large epiphyses", "Widened, distorted epiphyses" ; oboInOwl:id "HP:0010580" ; a owl:Class ; rdfs:label "Enlarged epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010582 obo:IAO_0000115 "An alteration of the normally smooth contour of the epiphysis leading to an irregular appearance." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasAlternativeId "HP:0002765", "HP:0003039", "HP:0005007", "HP:0005023", "HP:0005749", "HP:0010581" ; oboInOwl:hasDbXref "UMLS:C1846449" ; oboInOwl:hasExactSynonym "Irregular end part of long bone" ; oboInOwl:id "HP:0010582" ; a owl:Class ; rdfs:label "Irregular epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010583 obo:IAO_0000115 "Sclerosis of the epiphyses, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "UMLS:C1856911" ; oboInOwl:hasExactSynonym "Epiphyseal sclerosis", "Increased bone density in end part of bone" ; oboInOwl:id "HP:0010583" ; a owl:Class ; rdfs:label "Ivory epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010584 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "UMLS:C1841685" ; oboInOwl:id "HP:0010584" ; a owl:Class ; rdfs:label "Pseudoepiphyses" ; rdfs:subClassOf obo:HP_0005930 . obo:HP_0010585 obo:IAO_0000115 "Reduction in the size or volume of epiphyses." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasAlternativeId "HP:0005730" ; oboInOwl:hasDbXref "UMLS:C1846803" ; oboInOwl:hasExactSynonym "Small end part of bone" ; oboInOwl:id "HP:0010585" ; a owl:Class ; rdfs:label "Small epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010587 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "UMLS:C4023784" ; oboInOwl:hasExactSynonym "Triangular end part of bone" ; oboInOwl:id "HP:0010587" ; a owl:Class ; rdfs:label "Triangular epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010588 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at each end of a long bone, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T02:53:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89493005", "UMLS:C0151628" ; oboInOwl:hasExactSynonym "Premature closure of epiphyses" ; oboInOwl:id "HP:0010588" ; a owl:Class ; rdfs:comment "The epiphysis is the rounded end of a long bone, at its joint with adjacent bone." ; rdfs:label "Premature epimetaphyseal fusion" ; rdfs:subClassOf obo:HP_0005930 . obo:HP_0010590 obo:IAO_0000115 "Any abnormality of the distal epiphysis of the femur." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:00:23Z" ; oboInOwl:hasDbXref "UMLS:C4023783" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost thighbone" ; oboInOwl:id "HP:0010590" ; a owl:Class ; rdfs:label "Abnormality of the distal femoral epiphysis" ; rdfs:subClassOf obo:HP_0006499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004406 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010591 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the tibia." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:03:04Z" ; oboInOwl:hasDbXref "UMLS:C4023782" ; oboInOwl:hasExactSynonym "Abnormality of the end part of innermost shankbone", "Abnormality of the end part of innermost shinbone" ; oboInOwl:id "HP:0010591" ; a owl:Class ; rdfs:label "Abnormality of the proximal tibial epiphysis" ; rdfs:subClassOf obo:HP_0006508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008772 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010592 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:03:04Z" ; oboInOwl:hasDbXref "UMLS:C4023781" ; oboInOwl:hasExactSynonym "Abnormality of the end part of outermost shankbone", "Abnormality of the end part of outermost shinbone" ; oboInOwl:id "HP:0010592" ; a owl:Class ; rdfs:label "Abnormality of the distal tibial epiphysis" ; rdfs:subClassOf obo:HP_0006508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004405 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010593 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:03:34Z" ; oboInOwl:hasDbXref "UMLS:C4023780" ; oboInOwl:hasExactSynonym "Abnormality of fibular epiphyses", "Abnormality of the end part of the calf bone" ; oboInOwl:id "HP:0010593" ; a owl:Class ; rdfs:label "Abnormal fibular epiphysis morphology" ; rdfs:subClassOf obo:HP_0006500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004388 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010594 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the fibula." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:04:39Z" ; oboInOwl:hasDbXref "UMLS:C4023779" ; oboInOwl:hasExactSynonym "Abnormality of the innermost end part of calf bone" ; oboInOwl:id "HP:0010594" ; a owl:Class ; rdfs:label "Abnormality of the proximal fibular epiphysis" ; rdfs:subClassOf obo:HP_0010593 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010595 obo:IAO_0000115 "Any abnormality of the distal epiphysis of the fibula." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:04:39Z" ; oboInOwl:hasDbXref "UMLS:C4023778" ; oboInOwl:hasExactSynonym "Abnormality of the outermost end part of calf bone" ; oboInOwl:id "HP:0010595" ; a owl:Class ; rdfs:label "Abnormality of the distal fibular epiphysis" ; rdfs:subClassOf obo:HP_0010593 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004410 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010596 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the radius." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4023777" ; oboInOwl:id "HP:0010596" ; a owl:Class ; rdfs:label "Abnormality of the proximal radial epiphysis" ; rdfs:subClassOf obo:HP_0003946, obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010597 obo:IAO_0000115 "Any abnormality of the distal epiphysis of the radius." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T03:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4023776" ; oboInOwl:id "HP:0010597" ; a owl:Class ; rdfs:label "Abnormality of the distal radial epiphysis" ; rdfs:subClassOf obo:HP_0003999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010598 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the humerus." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T06:40:29Z" ; oboInOwl:hasDbXref "UMLS:C4023775" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost long bone in upper arm" ; oboInOwl:id "HP:0010598" ; a owl:Class ; rdfs:label "Abnormality of the proximal humeral epiphysis" ; rdfs:subClassOf obo:HP_0003891 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010599 obo:IAO_0000115 "Any abnormality of the distal epiphysis of the humerus." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T06:40:29Z" ; oboInOwl:hasDbXref "UMLS:C4023774" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost long bone in upper arm" ; oboInOwl:id "HP:0010599" ; a owl:Class ; rdfs:label "Abnormality of the distal humeral epiphysis" ; rdfs:subClassOf obo:HP_0003891, obo:HP_0003946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004404 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010600 obo:IAO_0000115 "Any abnormality of the distal epiphysis of the ulna." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T06:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023773" ; oboInOwl:hasExactSynonym "Abnormality of the distal ulnar epiphysis" ; oboInOwl:id "HP:0010600" ; a owl:Class ; rdfs:label "Abnormal distal ulnar epiphysis morphology" ; rdfs:subClassOf obo:HP_0004037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010601 obo:IAO_0000115 "Any abnormality of the proximal epiphysis of the ulna." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-22T06:41:21Z" ; oboInOwl:hasDbXref "UMLS:C4023772" ; oboInOwl:hasExactSynonym "Abnormality of the proximal ulnar epiphysis" ; oboInOwl:id "HP:0010601" ; a owl:Class ; rdfs:label "Abnormal proximal ulnar epiphysis morphology" ; rdfs:subClassOf obo:HP_0003946, obo:HP_0004037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006822 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010602 obo:IAO_0000115 "An abnormal predominance of type II muscle fibers (in general, this feature can only be observed on muscle biopsy)." ; dcterms:creator ; oboInOwl:creation_date "2009-10-25T09:56:24Z" ; oboInOwl:hasDbXref "UMLS:C3277187" ; oboInOwl:hasExactSynonym "Type 2 muscle fibre predominance", "Type II muscle fiber predominance", "Type II muscle fibre predominance" ; oboInOwl:id "HP:0010602" ; a owl:Class ; rdfs:label "Type 2 muscle fiber predominance" ; rdfs:subClassOf obo:HP_0033684 . obo:HP_0010603 obo:IAO_0000115 "A benign uni- or multicystic, intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T02:26:31Z" ; oboInOwl:hasDbXref "UMLS:C1708604" ; oboInOwl:hasExactSynonym "Keratocystic odontogenic tumor", "Keratocystic odontogenic tumour", "Keratocysts of the jaw" ; oboInOwl:id "HP:0010603" ; a owl:Class ; rdfs:comment "Keratocystic odontogenic tumor (KCOT) most commonly affects the mandible, but may also be localized in the maxilla." ; rdfs:label "Odontogenic keratocysts of the jaw" ; rdfs:subClassOf obo:HP_0100612 . obo:HP_0010604 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T10:57:50Z" ; oboInOwl:hasBroadSynonym "Lesion of the eyelid" ; oboInOwl:hasDbXref "SNOMEDCT_US:248514008", "SNOMEDCT_US:301913002", "SNOMEDCT_US:46210008", "UMLS:C0155218", "UMLS:C0424844", "UMLS:C0578590" ; oboInOwl:hasExactSynonym "Cyst of the eyelid", "Eyelid bump", "Eyelid mass" ; oboInOwl:id "HP:0010604" ; a owl:Class ; rdfs:label "Cyst of the eyelid" ; rdfs:subClassOf obo:HP_0010732, obo:HP_0200040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010605 obo:IAO_0000115 "A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T10:58:24Z" ; oboInOwl:hasDbXref "MSH:D017043", "SNOMEDCT_US:1482004", "UMLS:C0007933" ; oboInOwl:hasExactSynonym "Meibomian gland lipogranuloma" ; oboInOwl:id "HP:0010605" ; a owl:Class ; rdfs:label "Chalazion" ; rdfs:subClassOf obo:HP_0010604 . obo:HP_0010606 obo:IAO_0000115 "An acute purulent infection of the sebaceous glands of Zeis at the base of the eyelashes, of the apocrine sweat glands of Moll or the meibomian sebacious glands often caused by staphylococcus infections. Hordeola can either occur as Hordeola externa affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll or as Hordeola interna affecting the meibomian sebacious glands. In contrast to chalazia, hordeola are extremely painful and can cause extreme local swelling." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T11:01:13Z" ; oboInOwl:hasDbXref "MSH:D006726", "SNOMEDCT_US:1489008", "SNOMEDCT_US:397513003", "UMLS:C0019917", "UMLS:C4280376" ; oboInOwl:hasExactSynonym "Stye of eyelid" ; oboInOwl:hasRelatedSynonym "Red bump on eyelid" ; oboInOwl:id "HP:0010606" ; a owl:Class ; rdfs:label "Hordeolum" ; rdfs:subClassOf obo:HP_0010732 . obo:HP_0010607 obo:IAO_0000115 "Hordeola externa are acute purulent infections affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll, often caused by staphylococcus infections. In contrast to chalazia, hordeola are extremely painfull and can cause extreme local swelling." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T11:33:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:1489008", "UMLS:C0019919" ; oboInOwl:id "HP:0010607" ; a owl:Class ; rdfs:label "Hordeolum externum" ; rdfs:subClassOf obo:HP_0010606 . obo:HP_0010608 obo:IAO_0000115 "Hordeola interna are acute purulent infections affecting the meibomian sebacious glands, often caused by staphylococcus infections. In contrast to chalazia (chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland), hordeola are extremely painfull and can cause extreme local swelling." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T11:33:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:414521009", "UMLS:C0085690", "UMLS:C4280375" ; oboInOwl:hasExactSynonym "Stye of inner eyelid" ; oboInOwl:hasRelatedSynonym "Red bump on inner eyelid" ; oboInOwl:id "HP:0010608" ; a owl:Class ; rdfs:label "Hordeolum internum" ; rdfs:subClassOf obo:HP_0010606 . obo:HP_0010609 obo:IAO_0000115 "Cutaneous skin tags also known as acrochorda or fibroepithelial polyps are small benign tumors that may either form secondarily over time primarily in areas where the skin forms creases, such as the neck, armpit or groin or may also be present at birth, in which case they usually occur in the periauricular region." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-27T11:41:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:201091002", "SNOMEDCT_US:31069005", "SNOMEDCT_US:80801001", "UMLS:C0037293" ; oboInOwl:hasExactSynonym "Acrochorda" ; oboInOwl:id "HP:0010609" ; a owl:Class ; rdfs:label "Skin tags" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0010610 dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T01:23:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:247449001", "UMLS:C0423776" ; oboInOwl:id "HP:0010610" ; a owl:Class ; rdfs:label "Palmar pits" ; rdfs:subClassOf obo:HP_0040211, obo:HP_0100276 . obo:HP_0010612 obo:IAO_0000115 "The presence of multiple pits (small, pinpoint-large indentations on the surface of the skin) located on the skin of sole of foot." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T01:25:57Z" ; oboInOwl:hasDbXref "UMLS:C1852301" ; oboInOwl:id "HP:0010612" ; a owl:Class ; rdfs:label "Plantar pits" ; rdfs:subClassOf obo:HP_0100276, obo:HP_0100872 . obo:HP_0010614 obo:IAO_0000115 "Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term \"fibroblastic\" or \"fibromatous\" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T05:52:39Z" ; oboInOwl:hasDbXref "MSH:D005350", "NCIT:C3041", "SNOMEDCT_US:112682009", "SNOMEDCT_US:424568000", "UMLS:C0016045" ; oboInOwl:id "HP:0010614" ; a owl:Class ; rdfs:label "Fibroma" ; rdfs:subClassOf obo:HP_0012316, obo:HP_0030448 . obo:HP_0010615 obo:IAO_0000115 "Angiofibroma consist of many often dilated vessels." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T06:00:14Z" ; oboInOwl:hasDbXref "MSH:D018322", "NCIT:C3799", "SNOMEDCT_US:302857002", "SNOMEDCT_US:60392001", "UMLS:C0206731" ; oboInOwl:id "HP:0010615" ; a owl:Class ; rdfs:label "Angiofibromas" ; rdfs:subClassOf obo:HP_0010614 . obo:HP_0010616 obo:IAO_0000115 "The presence of a lung fibroma, a benign neoplasm that can present as a mass causing airway obstruction, cough, and hemoptysis, or present without symptoms as a solitary pulmonary nodule." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T06:04:01Z" ; oboInOwl:hasDbXref "NCIT:C3041", "SNOMEDCT_US:707387004", "UMLS:C1334444" ; oboInOwl:id "HP:0010616" ; a owl:Class ; rdfs:label "Lung fibroma" ; rdfs:subClassOf obo:HP_0010614, obo:HP_0100526 . obo:HP_0010617 obo:IAO_0000115 "A fibroma of the heart." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T06:13:11Z" ; oboInOwl:hasDbXref "NCIT:C3041", "UMLS:C1096654" ; oboInOwl:id "HP:0010617" ; a owl:Class ; rdfs:label "Cardiac fibroma" ; rdfs:subClassOf obo:HP_0010614, obo:HP_0100544 . obo:HP_0010618 obo:IAO_0000115 "The presence of a fibroma of the ovary." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T06:13:11Z" ; oboInOwl:hasDbXref "MSH:C562391", "NCIT:C3041", "SNOMEDCT_US:254865006", "UMLS:C0149951" ; oboInOwl:id "HP:0010618" ; a owl:Class ; rdfs:comment "Ovarian fibromas belong to the sex cord-stromal tumor group of ovarian neoplasms. Ovarian fibromas are most frequent during middle age, and rare in children. Upon gross pathological inspection, ovary fibromas are firm and white or tan." ; rdfs:label "Ovarian fibroma" ; rdfs:subClassOf obo:HP_0010614, obo:HP_0100615 . obo:HP_0010619 obo:IAO_0000115 "A benign biphasic tumor of the breast with epithelial and stromal components." ; dc:creator "sandra1" ; oboInOwl:creation_date "2009-10-28T06:13:11Z" ; oboInOwl:hasDbXref "NCIT:C3744", "SNOMEDCT_US:254845004", "UMLS:C0178421" ; oboInOwl:hasExactSynonym "Breast fibroadenoma", "Breast fibroadenomas", "Breast fibroadenosis", "Fibroadenosis - breast", "Fibroadenosis of breast" ; oboInOwl:id "HP:0010619" ; a owl:Class ; rdfs:comment "A connective tissue tumor of the breast which is usually benign and painless. Fibromas of the breast are more common in young woman." ; rdfs:label "Fibroadenoma of the breast" ; rdfs:subClassOf obo:HP_0010614, obo:HP_0100013 . obo:HP_0010620 obo:IAO_0000115 "Prominence of the malar process of the maxilla and infraorbital area appreciated in profile and from in front of the face." ; dcterms:creator ; oboInOwl:creation_date "2009-11-02T07:53:02Z" ; oboInOwl:hasAlternativeId "HP:0000310" ; oboInOwl:hasDbXref "UMLS:C1858732", "UMLS:C4280374" ; oboInOwl:hasExactSynonym "Malar excess", "Malar hyperplasia", "Prominent malar region" ; oboInOwl:hasNarrowSynonym "Hyperplasia of malar bones" ; oboInOwl:id "HP:0010620" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Increased prominence of the malar region (cheeks), as manifested by anterior positioning of the infraorbital and perialar regions or increased convexity of the face or increased naso-labial angle." ; rdfs:label "Malar prominence" ; rdfs:subClassOf obo:HP_0010668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002500 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010621 obo:IAO_0000115 "A soft tissue continuity in the anteroposterior axis between adjacent foot digits that involves at least half of the proximodistal length of one of the two involved digits; or, a soft tissue continuity in the A/P axis between two digits of the foot that does not meet the prior objective criteria." ; dcterms:creator ; oboInOwl:creation_date "2009-11-18T10:32:21Z" ; oboInOwl:hasAlternativeId "HP:0001990", "HP:0004707", "HP:0010555" ; oboInOwl:hasDbXref "UMLS:C1834737" ; oboInOwl:hasExactSynonym "Cutaneous syndactyly of feet", "Webbed skin of toes", "soft tissue syndactyly of toes" ; oboInOwl:id "HP:0010621" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cutaneous syndactyly of toes" ; rdfs:subClassOf obo:HP_0001770, obo:HP_0012725 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010554 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010622 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the skeleton." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T08:54:46Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:442868003", "UMLS:C2732838", "UMLS:C4020771" ; oboInOwl:hasExactSynonym "Skeletal tumor", "Skeletal tumour" ; oboInOwl:hasNarrowSynonym "Neoplasia of the skeletal system" ; oboInOwl:hasRelatedSynonym "Bone neoplasm" ; oboInOwl:id "HP:0010622" ; a owl:Class ; rdfs:label "Neoplasm of the skeletal system" ; rdfs:subClassOf obo:HP_0011793, obo:HP_0011842 . obo:HP_0010624 obo:IAO_0000115 "Absence or underdevelopment of the toenail." ; dcterms:creator ; oboInOwl:creation_date "2009-11-20T05:55:11Z" ; oboInOwl:hasAlternativeId "HP:0008381", "HP:0008389" ; oboInOwl:hasDbXref "UMLS:C1856749" ; oboInOwl:hasExactSynonym "Absent/small toenails", "Absent/underdeveloped toenails", "Aplastic/hypoplastic toenails", "Hypoplastic-absent toenails" ; oboInOwl:id "HP:0010624" ; a owl:Class ; rdfs:label "Aplastic/hypoplastic toenail" ; rdfs:subClassOf obo:HP_0008386, obo:HP_0008388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0001800 obo:HP_0001802 ) ] ] . obo:HP_0010625 obo:IAO_0000115 "Absence or underdevelopment of the anterior pituitary gland, also known as the adenohypophysis." ; dcterms:creator ; oboInOwl:creation_date "2009-12-05T03:03:17Z" ; oboInOwl:hasDbXref "MSH:D010903", "SNOMEDCT_US:62818001", "UMLS:C0032008", "UMLS:C4023771" ; oboInOwl:hasExactSynonym "Adenohypophysis" ; oboInOwl:id "HP:0010625" ; a owl:Class ; rdfs:label "Anterior pituitary dysgenesis" ; rdfs:subClassOf obo:HP_0011747 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010626 obo:IAO_0000115 "Absence of the anterior pituitary gland resulting from a developmental defect." ; dcterms:creator ; oboInOwl:creation_date "2009-12-05T03:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4021249" ; oboInOwl:hasExactSynonym "Absent pituitary gland", "Aplasia of the pituitary gland" ; oboInOwl:id "HP:0010626" ; a owl:Class ; rdfs:label "Anterior pituitary agenesis" ; rdfs:subClassOf obo:HP_0010625 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010627 obo:IAO_0000115 "Underdevelopment of the anterior pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2009-12-05T03:04:48Z" ; oboInOwl:hasAlternativeId "HP:0008238" ; oboInOwl:hasDbXref "UMLS:C0948740", "UMLS:C1859775" ; oboInOwl:hasExactSynonym "Small anterior pituitary lobe", "Underdeveloped pituitary gland" ; oboInOwl:hasRelatedSynonym "Hypoplasia of the pituitary gland" ; oboInOwl:id "HP:0010627" ; a owl:Class ; rdfs:label "Anterior pituitary hypoplasia" ; rdfs:subClassOf obo:HP_0010625 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010628 obo:IAO_0000115 "Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T05:08:30Z" ; oboInOwl:hasAlternativeId "HP:0000296", "HP:0000302", "HP:0000344", "HP:0000353", "HP:0002008", "HP:0002259", "HP:0002517", "HP:0004670", "HP:0007212", "HP:0200004" ; oboInOwl:hasDbXref "MSH:D005158", "MSH:D020330", "SNOMEDCT_US:193093009", "SNOMEDCT_US:95666008", "UMLS:C0376175", "UMLS:C0427055", "UMLS:C1858719" ; oboInOwl:hasExactSynonym "Bell's palsy", "Cranial nerve VII palsy", "Facial nerve palsy", "Facial nerve paralysis", "Facial palsy, unilateral or bilateral", "Seventh cranial nerve palsy", "VII th cranial nerve palsy" ; oboInOwl:hasRelatedSynonym "Facial muscle weakness of muscles innervated by CN VII" ; oboInOwl:id "HP:0010628" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Several conditions can cause a facial paralysis, e.g. brain tumor, stroke, and Lyme disease. However, if no specific cause can be identified, the condition is known as Bell's palsy. Named after Scottish anatomist Charles Bell, who first described it. Bell's palsy is the most common acute mononeuropathy (disease involving only one nerve) and is the most common cause of acute facial nerve paralysis." ; rdfs:label "Facial palsy" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0006824, obo:HP_0010827, obo:HP_0030319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010629 obo:IAO_0000115 "Any abnormality affecting the cortex of the humerus." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T05:45:26Z" ; oboInOwl:hasDbXref "UMLS:C4023770" ; oboInOwl:id "HP:0010629" ; a owl:Class ; rdfs:label "Abnormal morphology of the cortex of the humerus" ; rdfs:subClassOf obo:HP_0003103, obo:HP_0031095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004109 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010630 obo:IAO_0000115 "Any abnormality of a metatarsal bone epiphysis." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T05:58:36Z" ; oboInOwl:hasDbXref "UMLS:C4021248" ; oboInOwl:hasExactSynonym "Abnormality of end part of long bone of foot", "Abnormality of metatarsal epiphysis", "Abnormality of the epiphyses of the metatarsals" ; oboInOwl:id "HP:0010630" ; a owl:Class ; rdfs:label "Abnormal metatarsal epiphysis morphology" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0010631 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010631 obo:IAO_0000115 "Any abnormality of the epiphyses of the feet." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T06:00:04Z" ; oboInOwl:hasDbXref "UMLS:C4023769" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the foot bone" ; oboInOwl:id "HP:0010631" ; a owl:Class ; rdfs:label "Abnormality of the epiphyses of the feet" ; rdfs:subClassOf obo:HP_0006500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010632 obo:IAO_0000115 "Inability to detect any qualitative olfactory sensation." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T07:51:50Z" ; oboInOwl:hasDbXref "UMLS:C4023768" ; oboInOwl:id "HP:0010632" ; a owl:Class ; rdfs:label "Total anosmia" ; rdfs:subClassOf obo:HP_0000458 . obo:HP_0010633 obo:IAO_0000115 "Inability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants)." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T07:52:37Z" ; oboInOwl:hasDbXref "UMLS:C4023767" ; oboInOwl:id "HP:0010633" ; a owl:Class ; rdfs:label "Partial anosmia" ; rdfs:subClassOf obo:HP_0000458 . obo:HP_0010634 obo:IAO_0000115 "Reduced ability to detect any qualitative olfactory sensation." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T07:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4023766" ; oboInOwl:id "HP:0010634" ; a owl:Class ; rdfs:label "Total hyposmia" ; rdfs:subClassOf obo:HP_0004409 . obo:HP_0010635 obo:IAO_0000115 "Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants)." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T07:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4023765" ; oboInOwl:id "HP:0010635" ; a owl:Class ; rdfs:label "Partial hyposmia" ; rdfs:subClassOf obo:HP_0004409 . obo:HP_0010636 obo:IAO_0000115 "The presence of a cleft in the cerebral cortex unilaterally or bilaterally, usually located in the frontal area." ; dcterms:creator ; oboInOwl:creation_date "2009-12-06T08:05:54Z" ; oboInOwl:hasDbXref "MSH:D065707", "SNOMEDCT_US:253159001", "SNOMEDCT_US:38353004", "UMLS:C0266484" ; oboInOwl:id "HP:0010636" ; a owl:Class ; rdfs:label "Schizencephaly" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0010637 obo:IAO_0000115 "A form of amyloidosis that affects the conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2009-12-07T03:20:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:59017008", "UMLS:C0268402" ; oboInOwl:id "HP:0010637" ; a owl:Class ; rdfs:comment "The deposition of amyloid, a noncollagenous protein, in the conjunctiva, which presents as a discrete, nontender, nonulcerative, waxy, yellow-white subconjunctival tissue." ; rdfs:label "Conjunctival amyloidosis" ; rdfs:subClassOf obo:HP_0000502, obo:HP_0011034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_34 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010638 obo:IAO_0000115 "An abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." ; dcterms:creator ; oboInOwl:creation_date "2009-12-11T03:47:19Z" ; oboInOwl:hasDbXref "UMLS:C4023764" ; oboInOwl:hasExactSynonym "Elevated ALP of hepatic origin" ; oboInOwl:id "HP:0010638" ; a owl:Class ; rdfs:label "Elevated alkaline phosphatase of hepatic origin" ; rdfs:subClassOf obo:HP_0010679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010639 obo:IAO_0000115 "An abnormally increased level of bone isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." ; dcterms:creator ; oboInOwl:creation_date "2009-12-11T03:47:19Z" ; oboInOwl:hasAlternativeId "HP:0008266" ; oboInOwl:hasDbXref "UMLS:C1833667" ; oboInOwl:hasExactSynonym "Elevated ALP of bone origin", "Elevated alkaline phosphatase of bone origin", "Increased serum bone-specific alkaline phosphatase" ; oboInOwl:id "HP:0010639" ; a owl:Class ; rdfs:comment "Bone alkaline phosphatase (BALP) is encoded by the tissue non-specific form of alkaline phosphatase and thus is an isoform of this isoenzyme." ; rdfs:label "Elevated alkaline phosphatase of bone origin" ; rdfs:subClassOf obo:HP_0010679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010640 obo:IAO_0000115 "Abnormality of the nasal cavity (the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures)." ; dcterms:creator ; oboInOwl:creation_date "2009-12-17T04:56:17Z" ; oboInOwl:hasDbXref "UMLS:C4023763" ; oboInOwl:id "HP:0010640" ; a owl:Class ; rdfs:label "Abnormality of the nasal cavity" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010641 obo:IAO_0000115 "Abnormality of the midnasal cavity which includes the cavity between the nares and the choanae." ; dcterms:creator ; oboInOwl:creation_date "2009-12-17T04:58:21Z" ; oboInOwl:hasDbXref "UMLS:C4021861" ; oboInOwl:id "HP:0010641" ; a owl:Class ; rdfs:label "Abnormality of the midnasal cavity" ; rdfs:subClassOf obo:HP_0010640 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010643 obo:IAO_0000115 "Absence or abnormal closure of the midnasal cavity." ; dcterms:creator ; oboInOwl:creation_date "2009-12-17T05:06:01Z" ; oboInOwl:hasDbXref "UMLS:C4023762" ; oboInOwl:id "HP:0010643" ; a owl:Class ; rdfs:label "Midnasal atresia" ; rdfs:subClassOf obo:HP_0010644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010644 obo:IAO_0000115 "Abnormal narrowing (stenosis) of the midnasal cavity, i.e., of the middle nasal meatus, which in neonates can cause respiratory distress." ; dcterms:creator ; oboInOwl:creation_date "2009-12-17T05:06:01Z" ; oboInOwl:hasAlternativeId "HP:0010642" ; oboInOwl:hasDbXref "UMLS:C1840238" ; oboInOwl:hasExactSynonym "Midnasal atresia or stenosis" ; oboInOwl:id "HP:0010644" ; a owl:Class ; rdfs:label "Midnasal stenosis" ; rdfs:subClassOf obo:HP_0010641 . obo:HP_0010645 obo:IAO_0000115 "Absence of the distal phalanges of the toes." ; dcterms:creator ; oboInOwl:creation_date "2010-02-17T02:41:47Z" ; oboInOwl:hasDbXref "UMLS:C4023761" ; oboInOwl:hasExactSynonym "Absent outermost bone of the toes" ; oboInOwl:id "HP:0010645" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010185, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010646 obo:IAO_0000115 "An abnormal lack of stability of the cervical spine." ; dcterms:creator ; oboInOwl:creation_date "2010-02-23T11:15:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:202821008", "UMLS:C0410652" ; oboInOwl:id "HP:0010646" ; a owl:Class ; rdfs:comment "The cervical spine is made up of two anatomically and functionally distinct segments: the upper cervical spine (C1and C2), which possesses the most rotational mobility with some degrees of frontal and sagittal plane mobility, and the lower cervical spine, which allows for two types of movements - flexion-extension and inclination-rotation. Cervical instability mainly involves the upper cervical spine, particularly between C1 and C2. Craniocervical ligaments are the main determinants of cervical spine stability." ; rdfs:label "Cervical spine instability" ; rdfs:subClassOf obo:HP_0003319 . obo:HP_0010647 obo:IAO_0000115 "Any abnormal increase or reduction in skin elasticity." ; dcterms:creator ; oboInOwl:creation_date "2010-02-23T11:42:34Z" ; oboInOwl:hasDbXref "UMLS:C4023760" ; oboInOwl:id "HP:0010647" ; a owl:Class ; rdfs:label "Abnormal elasticity of skin" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001031 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010648 obo:IAO_0000115 "An abnormally increased ability of the skin to permit light to pass through (translucency) such that subcutaneous structures such as veins display an increased degree of visibility." ; dcterms:creator ; oboInOwl:creation_date "2010-02-23T11:50:37Z" ; oboInOwl:hasDbXref "UMLS:C1836646" ; oboInOwl:hasExactSynonym "Translucent skin" ; oboInOwl:id "HP:0010648" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dermal translucency" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001354 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010649 obo:IAO_0000115 "An abnormal degree of flatness of the Ala of nose, which can be defined as a reduced nasal elevation index (lateral depth of the nose from the tip of the nose to the insertion of the nasal ala in the cheek x 100 divided by the side-to-side breadth of the nasal alae)." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:01:47Z" ; oboInOwl:hasDbXref "UMLS:C4023759" ; oboInOwl:hasExactSynonym "Depressed nasal alae" ; oboInOwl:hasNarrowSynonym "Flat nasal alar cartilage" ; oboInOwl:id "HP:0010649" ; a owl:Class ; rdfs:label "Flat nasal alae" ; rdfs:subClassOf obo:HP_0000429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006906 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010650 obo:IAO_0000115 "An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:11:43Z" ; oboInOwl:hasDbXref "UMLS:C4020770", "UMLS:C4072878" ; oboInOwl:hasExactSynonym "Decreased size of premaxilla", "Decreased size of the primary palate bone", "Hypoplasia of the intermaxillary bone", "Hypoplasia of the primary palate bone", "Premaxillary bone deficiency", "Premaxillary underdevelopment", "Primary palate bone deficiency", "Small premaxilla", "Small primary palate bone", "Underdevelopment of premaxilla", "Underdevelopment of the premaxilla", "Underdevelopment of the primary palate bone" ; oboInOwl:hasRelatedSynonym "Premaxillary bone retrusion", "Premaxillary retrusion", "Primary palate bone retrusion" ; oboInOwl:id "HP:0010650" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplasia of the premaxilla" ; rdfs:subClassOf obo:HP_0002692, obo:HP_0010756 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010651 obo:IAO_0000115 "An abnormality of the Meninges, including any abnormality of the Dura mater, the Arachnoid mater, and the Pia mater." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:19:40Z" ; oboInOwl:hasDbXref "UMLS:C4023758" ; oboInOwl:hasExactSynonym "Abnormality of the meninges" ; oboInOwl:id "HP:0010651" ; a owl:Class ; rdfs:label "Abnormal meningeal morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002360 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010652 obo:IAO_0000115 "An abnormality of the Dura mater." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:29:40Z" ; oboInOwl:hasDbXref "UMLS:C4023757" ; oboInOwl:hasExactSynonym "Abnormality of the dura mater" ; oboInOwl:id "HP:0010652" ; a owl:Class ; rdfs:label "Abnormal dura mater morphology" ; rdfs:subClassOf obo:HP_0010651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002363 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010653 obo:IAO_0000115 "An abnormality of the Falx cerebri." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:32:52Z" ; oboInOwl:hasDbXref "UMLS:C4021247" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral falx" ; oboInOwl:id "HP:0010653" ; a owl:Class ; rdfs:comment "The falx cerebri refers to the fold of dura mater which descends vertically in the longitudinal fissure between the cerebral hemispheres." ; rdfs:label "Abnormality of the falx cerebri" ; rdfs:subClassOf obo:HP_0010652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010654 obo:IAO_0000115 "A developmental defect characterized by aplasia of the Falx cerebri." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:35:26Z" ; oboInOwl:hasDbXref "UMLS:C4023756" ; oboInOwl:hasExactSynonym "Absent cerebral falx" ; oboInOwl:id "HP:0010654" ; a owl:Class ; rdfs:label "Aplasia of the falx cerebri" ; rdfs:subClassOf obo:HP_0010653 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010655 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T09:41:24Z" ; oboInOwl:hasAlternativeId "HP:0002658", "HP:0010586" ; oboInOwl:hasDbXref "SNOMEDCT_US:360507004", "UMLS:C1859126" ; oboInOwl:hasExactSynonym "Epiphyseal punctate calcifications", "Speckled calcifications in end part of bone", "Stippled epiphyses", "Stippling of the epiphyses" ; oboInOwl:id "HP:0010655" ; a owl:Class ; rdfs:comment "Stippling resolves with maturation of the epiphysis but is often replaced by some permament epiphyseal abnormality." ; rdfs:label "Epiphyseal stippling" ; rdfs:subClassOf obo:HP_0005930, obo:HP_0010656, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010656 obo:IAO_0000115 "An abnormality of the formation and mineralization of an epiphysis." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T09:43:04Z" ; oboInOwl:hasDbXref "UMLS:C4021246" ; oboInOwl:hasExactSynonym "Abnormality of the mineralisation or ossification of the epiphyses" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of the end part of a bone" ; oboInOwl:id "HP:0010656" ; a owl:Class ; rdfs:label "Abnormal epiphyseal ossification" ; rdfs:subClassOf obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001437 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010657 obo:IAO_0000115 "Patchy (irregular) reduction in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:32:54Z" ; oboInOwl:hasDbXref "UMLS:C4023755" ; oboInOwl:id "HP:0010657" ; a owl:Class ; rdfs:label "Patchy reduction of bone mineral density" ; rdfs:subClassOf obo:HP_0002797, obo:HP_0004349, obo:HP_0010658 . obo:HP_0010658 obo:IAO_0000115 "Patchy (irregular) changes in bone mineral density. These changes can either be patchy reduction or increase of mineral density as seen on x-rays. Depending on the pathomechanism and the underlying disease, these changes can either appear solely as reduction or increase or as a combination of both (patches of bone showing an increased density while others are affected by reduction of mineral density)." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:42:39Z" ; oboInOwl:hasDbXref "UMLS:C4023754" ; oboInOwl:id "HP:0010658" ; a owl:Class ; rdfs:label "Patchy changes of bone mineral density" ; rdfs:subClassOf obo:HP_0004348 . obo:HP_0010659 obo:IAO_0000115 "Patchy (irregular) changes in bone mineral density with patches of bone showing an increased density side to side with patches that are affected by reduction of mineral density. This is sometimes referred to as a moth-eaten appearance on x-rays." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T10:49:23Z" ; oboInOwl:hasDbXref "UMLS:C4021245" ; oboInOwl:hasExactSynonym "Patchy increased and decreased bone mineral density" ; oboInOwl:id "HP:0010659" ; a owl:Class ; rdfs:label "Patchy variation in bone mineral density" ; rdfs:subClassOf obo:HP_0004349, obo:HP_0010658 . obo:HP_0010660 obo:IAO_0000115 "An abnormality of the formation and mineralization of any bone of the skeleton of hand." ; dcterms:creator ; oboInOwl:creation_date "2010-02-25T05:18:19Z" ; oboInOwl:hasAlternativeId "HP:0005921" ; oboInOwl:hasDbXref "UMLS:C4021244" ; oboInOwl:hasExactSynonym "Abnormal ossification of hand bones", "Abnormality of the mineralisation and ossification of bones of the hand" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of the hand bones" ; oboInOwl:id "HP:0010660" ; a owl:Class ; rdfs:label "Abnormal hand bone ossification" ; rdfs:subClassOf obo:HP_0003336, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001442 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010661 obo:IAO_0000115 "A developmental defect characterized by the absence of the third ventricle." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:00:47Z" ; oboInOwl:hasDbXref "UMLS:C4023753" ; oboInOwl:id "HP:0010661" ; a owl:Class ; rdfs:label "Absence of the third cerebral ventricle" ; rdfs:subClassOf obo:HP_0010951 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002286 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010662 obo:IAO_0000115 "An abnormality of the Diencephalon, which together with the cerebrum (telencephalon) makes up the forebrain." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:02:38Z" ; oboInOwl:hasDbXref "UMLS:C4023752" ; oboInOwl:id "HP:0010662" ; a owl:Class ; rdfs:comment "The diencephalon comprises the thalamus, hypothalamus, epithalamus, prethalamus or subthalamus and pretectum." ; rdfs:label "Abnormality of the diencephalon" ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001894 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010663 obo:IAO_0000115 "An abnormality of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:03:50Z" ; oboInOwl:hasDbXref "UMLS:C4021243" ; oboInOwl:hasExactSynonym "Abnormal shape of thalamus", "Abnormality of the thalamus" ; oboInOwl:id "HP:0010663" ; a owl:Class ; rdfs:label "Abnormality of thalamus morphology" ; rdfs:subClassOf obo:HP_0010662 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010664 obo:IAO_0000115 "A developmental defect characterized by fusion of the left and right halves of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:04:37Z" ; oboInOwl:hasDbXref "UMLS:C1834930", "UMLS:C4020769" ; oboInOwl:hasExactSynonym "Fused thalami", "Undivided thalami" ; oboInOwl:hasRelatedSynonym "Fusion of thamali" ; oboInOwl:id "HP:0010664" ; a owl:Class ; rdfs:label "Fusion of the left and right thalami" ; rdfs:subClassOf obo:HP_0010663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0013684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010665 obo:IAO_0000115 "The presence of bilateral coxa valga." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:07:03Z" ; oboInOwl:hasDbXref "UMLS:C3810018" ; oboInOwl:id "HP:0010665" ; a owl:Class ; rdfs:label "Bilateral coxa valga" ; rdfs:subClassOf obo:HP_0002673 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002673 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0010666 obo:IAO_0000115 "Underdevelopment of the anterior nasal spine of maxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:10:11Z" ; oboInOwl:hasDbXref "UMLS:C4023751", "UMLS:C4280372", "UMLS:C4280373" ; oboInOwl:hasExactSynonym "Decreased projection of anterior nasal spine", "Decreased size of anterior nasal spine", "Small anterior nasal spine", "Underdevelopment of anterior nasal spine" ; oboInOwl:hasNarrowSynonym "Decreased length of anterior nasal spine" ; oboInOwl:hasRelatedSynonym "Deficiency of anterior nasal spine", "Hypotrophic anterior nasal spine" ; oboInOwl:id "HP:0010666" ; a owl:Class ; rdfs:label "Hypoplasia of the anterior nasal spine" ; rdfs:subClassOf obo:HP_0000327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035139 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010667 obo:IAO_0000115 "A congenital defect characterized by absence of the Maxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:11:45Z" ; oboInOwl:hasBroadSynonym "Failure of development of upper jaw bones" ; oboInOwl:hasDbXref "UMLS:C4023750", "UMLS:C4280371" ; oboInOwl:hasExactSynonym "Absence of the maxilla", "Absence of upper jaw bones", "Agenesis of the maxilla", "Aplasia of the upper jaw bones", "Failure of development of maxilla" ; oboInOwl:hasNarrowSynonym "Missing upper jaw bones" ; oboInOwl:id "HP:0010667" ; a owl:Class ; rdfs:label "Aplasia of the maxilla" ; rdfs:subClassOf obo:HP_0000326, obo:HP_0040008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010668 obo:IAO_0000115 "An abnormality of the zygomatic bone." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:13:11Z" ; oboInOwl:hasAlternativeId "HP:0012369" ; oboInOwl:hasDbXref "UMLS:C4023749" ; oboInOwl:hasExactSynonym "Abnormal malar bone morphology", "Abnormality of the cheekbone", "Abnormality of the zygomatic bone" ; oboInOwl:hasNarrowSynonym "Anomaly of the zygomatic bone", "Deformity of the cheekbone", "Deformity of the zygomatic bone", "Malformation of the zygomatic bone" ; oboInOwl:id "HP:0010668" ; a owl:Class ; rdfs:label "Abnormal zygomatic bone morphology" ; rdfs:subClassOf obo:HP_0000309, obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010669 obo:IAO_0000115 "Underdevelopment of the zygomatic bone. That is, a reduction in size of the zygomatic bone, including the zygomatic process of the temporal bone of the skull, which forms part of the zygomatic arch." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:14:04Z" ; oboInOwl:hasBroadSynonym "Depressed cheekbone", "Depressed zygomatic bone", "Flattening of the zygomatic bone", "Small cheekbone", "Small malar bone", "Small zygomatic bone" ; oboInOwl:hasDbXref "UMLS:C4021242", "UMLS:C4072879", "UMLS:C4280368", "UMLS:C4280369", "UMLS:C4280370" ; oboInOwl:hasExactSynonym "Cheekbone underdevelopment", "Decreased size of cheekbone", "Decreased size of zygomatic bone", "Hypoplasia of cheekbone", "Underdevelopment of cheekbone", "Underdevelopment of zygomatic bone" ; oboInOwl:hasRelatedSynonym "Hypotrophic cheekbone", "Hypotrophic zygomatic bone", "Hypotrophy of the cheekbone", "Hypotrophy of the zygomatic bone" ; oboInOwl:id "HP:0010669" ; a owl:Class ; rdfs:label "Hypoplasia of the zygomatic bone" ; rdfs:subClassOf obo:HP_0002692, obo:HP_0010668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010672 obo:IAO_0000115 "An abnormality of the third metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2010-02-26T08:22:51Z" ; oboInOwl:hasDbXref "UMLS:C4023748" ; oboInOwl:hasExactSynonym "Abnormality of the 3rd long bone of foot" ; oboInOwl:id "HP:0010672" ; a owl:Class ; rdfs:label "Abnormality of the third metatarsal bone" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010674 obo:IAO_0000115 "The presence of an abnormal curvature of the vertebral column." ; dc:creator "sandra1" ; oboInOwl:creation_date "2010-02-27T06:28:19Z" ; oboInOwl:hasDbXref "UMLS:C4023747" ; oboInOwl:hasExactSynonym "Abnormal curve of the backbone", "Abnormal curve of the spine", "Abnormal curving of the spine", "Abnormality of the curvature of the vertebral column", "Curvature of spine", "Curved spine" ; oboInOwl:id "HP:0010674" ; a owl:Class ; rdfs:label "Abnormal curvature of the vertebral column" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001591 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010675 obo:IAO_0000115 "An abnormality of the formation and mineralization of any bone of the skeleton of foot." ; dc:creator "sandra1" ; oboInOwl:creation_date "2010-02-28T05:27:47Z" ; oboInOwl:hasAlternativeId "HP:0008370", "HP:0009133" ; oboInOwl:hasDbXref "UMLS:C4020768", "UMLS:C4021241", "UMLS:C4280367" ; oboInOwl:hasExactSynonym "Abnormality of the mineralisation and ossification of bones of the feet" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of foot bones", "Abnormal ossification involving bones of the feet" ; oboInOwl:id "HP:0010675" ; a owl:Class ; rdfs:label "Abnormal foot bone ossification" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001445 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010676 dc:creator "sandra1" ; oboInOwl:creation_date "2010-03-01T08:43:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46420000", "UMLS:C0400843" ; oboInOwl:id "HP:0010676" ; a owl:Class ; rdfs:label "Mechanical ileus" ; rdfs:subClassOf obo:HP_0002595 . obo:HP_0010677 obo:IAO_0000115 "Enuresis occurring during sleeping hours." ; dc:creator "sandra1" ; oboInOwl:creation_date "2010-03-01T09:11:31Z" ; oboInOwl:hasDbXref "MSH:D053206", "SNOMEDCT_US:8009008", "UMLS:C0270327" ; oboInOwl:hasExactSynonym "Nocturnal enuresis" ; oboInOwl:id "HP:0010677" ; a owl:Class ; rdfs:label "Enuresis nocturna" ; rdfs:subClassOf obo:HP_0000805 . obo:HP_0010678 obo:IAO_0000115 "Enuresis occurring during waking hours of the day." ; dc:creator "sandra1" ; oboInOwl:creation_date "2010-03-01T09:11:51Z" ; oboInOwl:hasDbXref "UMLS:C4023746" ; oboInOwl:id "HP:0010678" ; a owl:Class ; rdfs:label "Enuresis diurna" ; rdfs:subClassOf obo:HP_0000805 . obo:HP_0010679 obo:IAO_0000115 "An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:08:35Z" ; oboInOwl:hasDbXref "UMLS:C4021240" ; oboInOwl:hasExactSynonym "Elevated alkaline phosphatase, liver/bone/kidney", "Elevated tissue non-specific ALP" ; oboInOwl:id "HP:0010679" ; a owl:Class ; rdfs:comment "Tissue non-specific alkaline phosphatase (ALPP) is one of four distinct but related alkaline phosphatases. Entrez Gene ID 249, Uniprot P05186 (PPBT_HUMAN). The gene is also known as alkaline phosphatase, liver/bone/kidney (ALPL)." ; rdfs:label "Elevated tissue non-specific alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003968 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010680 obo:IAO_0000115 "An abnormally increased level of kidney isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:09:59Z" ; oboInOwl:hasDbXref "UMLS:C4023745" ; oboInOwl:hasExactSynonym "Elevated ALP of renal origin" ; oboInOwl:id "HP:0010680" ; a owl:Class ; rdfs:label "Elevated alkaline phosphatase of renal origin" ; rdfs:subClassOf obo:HP_0010679, obo:HP_0012211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010681 obo:IAO_0000115 "An abnormally increased level of alkaline phosphatase, intestinal type in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:10:34Z" ; oboInOwl:hasDbXref "UMLS:C4023744" ; oboInOwl:hasExactSynonym "Elevated intestinal ALP" ; oboInOwl:id "HP:0010681" ; a owl:Class ; rdfs:comment "Intestinal alkaline phosphatase (IAP) is one of four distinct but related alkaline phosphatases. Entrez Gene ID:248, Uniprot ID: P09923 (PPBI_HUMAN)." ; rdfs:label "Elevated intestinal alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010682 obo:IAO_0000115 "An abnormally increased level of alkaline phosphatase, placental type in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:11:06Z" ; oboInOwl:hasDbXref "UMLS:C4023743" ; oboInOwl:hasExactSynonym "Elevated placental ALP" ; oboInOwl:id "HP:0010682" ; a owl:Class ; rdfs:comment "Placental alkaline phosphatase (ALPP) is one of four distinct but related alkaline phosphatases. Entrez Gene ID 250, Uniprot P05187 (PPB1_HUMAN)." ; rdfs:label "Elevated placental alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003969 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010683 obo:IAO_0000115 "An abnormally reduced level of alkaline phosphatase, tissue-nonspecific isozyme in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:12:08Z" ; oboInOwl:hasDbXref "UMLS:C4023742" ; oboInOwl:hasExactSynonym "Low tissue non-specific ALP" ; oboInOwl:id "HP:0010683" ; a owl:Class ; rdfs:label "Low tissue non-specific alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003968 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010684 obo:IAO_0000115 "An abnormally reduced level of bone isoforms of alkaline phosphatase in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:12:47Z" ; oboInOwl:hasDbXref "UMLS:C4023741" ; oboInOwl:hasExactSynonym "Low ALP of bone origin" ; oboInOwl:id "HP:0010684" ; a owl:Class ; rdfs:label "Low alkaline phosphatase of bone origin" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010685 obo:IAO_0000115 "An abnormally reduced level of kidney isoforms of alkaline phosphatase in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:12:47Z" ; oboInOwl:hasDbXref "UMLS:C4023740" ; oboInOwl:hasExactSynonym "Low ALP of renal origin" ; oboInOwl:id "HP:0010685" ; a owl:Class ; rdfs:label "Low alkaline phosphatase of renal origin" ; rdfs:subClassOf obo:HP_0003282, obo:HP_0012211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010686 obo:IAO_0000115 "An abnormally reduced level of liver isoforms of alkaline phosphatase in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:12:47Z" ; oboInOwl:hasDbXref "UMLS:C4023739" ; oboInOwl:hasExactSynonym "Low ALP of hepatic origin" ; oboInOwl:id "HP:0010686" ; a owl:Class ; rdfs:label "Low alkaline phosphatase of hepatic origin" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010687 obo:IAO_0000115 "An abnormally reduced level of alkaline phosphatase, intestinal type in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:13:10Z" ; oboInOwl:hasDbXref "UMLS:C4023738" ; oboInOwl:hasExactSynonym "Low intestinal ALP" ; oboInOwl:id "HP:0010687" ; a owl:Class ; rdfs:label "Low intestinal alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010688 obo:IAO_0000115 "An abnormally reduced level of alkaline phosphatase, placental type in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T11:13:28Z" ; oboInOwl:hasDbXref "UMLS:C4023737" ; oboInOwl:hasExactSynonym "Low placental ALP" ; oboInOwl:id "HP:0010688" ; a owl:Class ; rdfs:label "Low placental alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000003969 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010689 obo:IAO_0000115 "A hand or foot with more than five digits that has a recognizable A/P axis of symmetry. The axis can lie within a normally formed or partially duplicated digit resembling a middle finger, index finger, thumb, toe, or hallux. Alternatively, the axis can be in an interdigital space with a flanking pair of digits that resemble a middle finger, index finger, thumb, toe or hallux. The most lateral digits on each side of the hand/foot typically resemble fifth fingers/toes." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T05:03:16Z" ; oboInOwl:hasDbXref "MSH:C535689", "SNOMEDCT_US:715440003", "UMLS:C1851100" ; oboInOwl:hasExactSynonym "Mirror image duplication of digits" ; oboInOwl:id "HP:0010689" ; a owl:Class ; rdfs:comment "Transplantation of the ZPA (zone of polarised activity) to the anterior margin of a limb bud in the chick results in mirror image duplication of limb elements (Tabin, 1991). Similarly, mirror image duplication in the forelimb of the mouse has been observed with ectopic expression of Hox b-8 (Charit6 et al, 1994). Mirror hand anomaly in humans has been shown to be due to either aberrant positioning of the ZPA or altered inductive interactions of the Shh gene resulting in impairment of the mechanism responsible for the organization and differentiation of the limb bud, rather than a primary duplication event. In other words, the primary event results in failure of the radial ray to develop. The ulnar area will then induce the differentiation of two groups of ulnar rays. Timing of this insult could play a critical role in severity of this phenotypic feature. Syndromal mirror hand is probably due to agene mutation of the Shh gene (Hersh et al, 1995). Finally, the multiple hand deformity may be explained by true duplication of the ZPA." ; rdfs:label "Mirror image polydactyly" ; rdfs:subClassOf obo:HP_0010442 . obo:HP_0010690 obo:IAO_0000115 "Mirror image duplication of digits affecting the hands only." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T05:05:05Z" ; oboInOwl:hasDbXref "UMLS:C4021239" ; oboInOwl:hasExactSynonym "Mirror image dupliction of fingers" ; oboInOwl:id "HP:0010690" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Mirror image hand polydactyly" ; rdfs:subClassOf obo:HP_0001161, obo:HP_0010689 . obo:HP_0010691 obo:IAO_0000115 "Mirror image duplication of digits affecting the feet." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T05:05:05Z" ; oboInOwl:hasDbXref "UMLS:C4021238" ; oboInOwl:hasExactSynonym "Mirror image dupliction of toes" ; oboInOwl:id "HP:0010691" ; a owl:Class ; rdfs:label "Mirror image foot polydactyly" ; rdfs:subClassOf obo:HP_0001829, obo:HP_0010689 . obo:HP_0010692 obo:IAO_0000115 "Syndactyly with fusion of fingers two to five." ; dcterms:creator ; oboInOwl:creation_date "2010-03-05T06:41:50Z" ; oboInOwl:hasDbXref "UMLS:C4023736" ; oboInOwl:hasExactSynonym "Webbed 2nd-5th fingers", "Webbed index, middle and little finger", "Webbed index, middle and pinkie finger", "Webbed index, middle and pinky finger" ; oboInOwl:id "HP:0010692" ; a owl:Class ; rdfs:label "2-5 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010710 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010693 obo:IAO_0000115 "A kind of congenital cataract that is characterized by a hollow sphere of punctate opacities involving the fetal nucleus and that usually occurs bilaterally." ; dcterms:creator ; oboInOwl:creation_date "2010-03-11T02:49:53Z" ; oboInOwl:hasDbXref "MSH:C563426", "UMLS:C1833118" ; oboInOwl:hasExactSynonym "Pulverulent cataract" ; oboInOwl:id "HP:0010693" ; a owl:Class ; rdfs:comment "The word \"pulverulent \" means dust-like and refers to the dustlike appearance of the punctate opacities in this type of cataract. The word pulverulent refers to the very small size of the punctate opacities (like flecks of dust) rather than to a dust-like color." ; rdfs:label "Pulverulent cataract" ; rdfs:subClassOf obo:HP_0007648 . obo:HP_0010694 obo:IAO_0000115 "A Lamellar cataract with a pulverulent (punctate, \"dust-like\" opacities) appearance." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T11:43:14Z" ; oboInOwl:hasDbXref "UMLS:C4023735" ; oboInOwl:id "HP:0010694" ; a owl:Class ; rdfs:comment "Opacities located in the perinuclear (lamellar) zones of the lens." ; rdfs:label "Lamellar pulverulent cataract" ; rdfs:subClassOf obo:HP_0007971 . obo:HP_0010695 obo:IAO_0000115 "A type of congenital cataract in which the opacity follows the anterior or posterior Y suture." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T12:07:04Z" ; oboInOwl:hasDbXref "UMLS:C4023734" ; oboInOwl:id "HP:0010695" ; a owl:Class ; rdfs:comment "During lens terminal differentiation, the originally cuboidal lens vesicle cells elongate into long fiber-like cells, or fibers. Y-shaped sutures form because of how the lens epithelial cells proliferate during formation. The Y sutures demarcate the boundaries between the lens cortex, which is peripheral to the Y sutures, and the lens nucleus, which is within and includes the Y sutures. The anterior Y suture is oriented upright, and the posterior Y suture is inverted." ; rdfs:label "Sutural cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0010696 obo:IAO_0000115 "A type of Congenital cataract in which the opacities occupy the subcapsular cortex at the anterior or posterior pole of the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T02:36:22Z" ; oboInOwl:hasDbXref "UMLS:C2025392" ; oboInOwl:id "HP:0010696" ; a owl:Class ; rdfs:label "Polar cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0010697 obo:IAO_0000115 "A type of anterior polar cataract which projects as a conical opacity into the anterior chamber." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T02:38:57Z" ; oboInOwl:hasDbXref "UMLS:C1392099" ; oboInOwl:hasRelatedSynonym "Pyramidal cataract" ; oboInOwl:id "HP:0010697" ; a owl:Class ; rdfs:label "Anterior pyramidal cataract" ; rdfs:subClassOf obo:HP_0001134 . obo:HP_0010698 obo:IAO_0000115 "A type of nuclear cataract involving congenital dust-like (pulverulent) opacity of the embryonal and fetal nucleus." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T02:53:02Z" ; oboInOwl:hasDbXref "UMLS:C4021237" ; oboInOwl:hasExactSynonym "Central pulverulent cataract", "Coppock-like cataract", "Pulverulent nuclear cataract", "cataracta pulverulenta centralis" ; oboInOwl:id "HP:0010698" ; a owl:Class ; rdfs:label "Nuclear pulverulent cataract" ; rdfs:subClassOf obo:HP_0010693, obo:HP_0010925 . obo:HP_0010699 obo:IAO_0000115 "A nuclear cataract with a triangular form." ; dcterms:creator ; oboInOwl:creation_date "2010-03-20T02:58:26Z" ; oboInOwl:hasDbXref "UMLS:C4023733" ; oboInOwl:id "HP:0010699" ; a owl:Class ; rdfs:label "Triangular nuclear cataract" ; rdfs:subClassOf obo:HP_0100018 . obo:HP_0010700 obo:IAO_0100001 "HP:0000518" ; oboInOwl:id "HP:0010700" ; a owl:Class ; rdfs:label "obsolete Total cataract" ; owl:deprecated true . obo:HP_0010701 obo:IAO_0000115 "An abnormal deviation from normal levels of immunoglobulins in blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-22T08:17:49Z" ; oboInOwl:hasAlternativeId "HP:0100032" ; oboInOwl:hasDbXref "UMLS:C1855755" ; oboInOwl:hasExactSynonym "Abnormal immunoglobulin concentration", "Abnormal serum immunoglobulin concentration", "Abnormal serum immunoglobulin levels", "Abnormal serum level of immunoglobulin", "Immunoglobulin abnormality" ; oboInOwl:id "HP:0010701" ; a owl:Class ; rdfs:comment """'has part' some (amount and ('inheres in' some (IMR_0002090 and ('part of' some blood))) and ('has modifier' some abnormal))""" ; rdfs:label "Abnormal immunoglobulin level" ; rdfs:subClassOf obo:HP_0005368, obo:HP_0005372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042571 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010702 obo:IAO_0000115 "An increased level of gamma globulin (immunoglobulin) in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-03-22T08:20:07Z" ; oboInOwl:hasAlternativeId "HP:0002852", "HP:0004314", "HP:0004435" ; oboInOwl:hasDbXref "MSH:D006942", "SNOMEDCT_US:127388009", "SNOMEDCT_US:129646001", "UMLS:C0020455", "UMLS:C0151669", "UMLS:C0541985", "UMLS:C1306857", "UMLS:C2048011" ; oboInOwl:hasExactSynonym "Elevated immunoglobulin levels", "Hypergammaglobulinaemia", "Hypergammaglobulinemia", "Hyperglobulinemia", "Increased antibody level in blood", "Increased gamma globulin", "Increased immunoglobulin level", "Increased serum gamma globulin", "Raised immunoglobulin levels" ; oboInOwl:id "HP:0010702" ; a owl:Class ; rdfs:comment "In humans, immunoglobulins comprise the five antibody isotypes IgA, IgD, IgE, IgG and IgM." ; rdfs:label "Increased circulating antibody level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042571 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010704 obo:IAO_0000115 "Syndactyly with fusion of fingers one and two." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:07:14Z" ; oboInOwl:hasDbXref "UMLS:C4023732" ; oboInOwl:hasExactSynonym "Webbed 1st-2nd finger", "Webbed thumb and index finger" ; oboInOwl:id "HP:0010704" ; a owl:Class ; rdfs:label "1-2 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010705 obo:IAO_0000115 "Syndactyly with fusion of fingers four and five." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4023731" ; oboInOwl:hasExactSynonym "Webbed 4th-5th finger" ; oboInOwl:id "HP:0010705" ; a owl:Class ; rdfs:label "4-5 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003625 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010706 obo:IAO_0000115 "Syndactyly with fusion of fingers one to three." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4023730" ; oboInOwl:hasExactSynonym "Webbed 1st-3rd finger" ; oboInOwl:id "HP:0010706" ; a owl:Class ; rdfs:label "1-3 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001233 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010704 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010707 obo:IAO_0000115 "Syndactyly with fusion of fingers one to four." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4023729" ; oboInOwl:hasExactSynonym "Webbed 1st-4th finger" ; oboInOwl:id "HP:0010707" ; a owl:Class ; rdfs:label "1-4 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0006097 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010708 obo:IAO_0000115 "Syndactyly with fusion of fingers one to five (complete syndactyly of all fingers of the hand)." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4023728" ; oboInOwl:hasExactSynonym "Webbed 1-5 fingers", "Webbed 1st-5th fingers" ; oboInOwl:id "HP:0010708" ; a owl:Class ; rdfs:label "1-5 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010706 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010710 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010709 obo:IAO_0000115 "Syndactyly with fusion of the fingers two to four." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasAlternativeId "HP:0005797", "HP:0006018" ; oboInOwl:hasDbXref "UMLS:C4021236" ; oboInOwl:hasExactSynonym "Syndactyly of second to fourth fingers", "Webbed index through ring fingers" ; oboInOwl:id "HP:0010709" ; a owl:Class ; rdfs:label "2-4 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0001233 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0006097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010710 obo:IAO_0000115 "Syndactyly with fusion of fingers three to five." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4023727" ; oboInOwl:hasExactSynonym "Webbed third, fourth and fifth toes" ; oboInOwl:id "HP:0010710" ; a owl:Class ; rdfs:label "3-5 finger syndactyly" ; rdfs:subClassOf obo:HP_0006101 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0006097 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010711 obo:IAO_0000115 "Syndactyly with fusion of toes one and two." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023726" ; oboInOwl:hasExactSynonym "Webbed 1st-2nd toes", "Webbed first and second toes" ; oboInOwl:id "HP:0010711" ; a owl:Class ; rdfs:label "1-2 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010712 obo:IAO_0000115 "Syndactyly with fusion of toes one to four." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023725" ; oboInOwl:hasExactSynonym "Webbed first through fourth toes" ; oboInOwl:id "HP:0010712" ; a owl:Class ; rdfs:label "1-4 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010711 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010713 obo:IAO_0000115 "Syndactyly with fusion of toes one to five (complete syndactyly of all toes of the foot)." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasAlternativeId "HP:0005812" ; oboInOwl:hasDbXref "UMLS:C4021235" ; oboInOwl:hasExactSynonym "Syndactyly of all toes", "Webbed 1st-5th toes" ; oboInOwl:id "HP:0010713" ; a owl:Class ; rdfs:label "1-5 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004692 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010712 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010714 obo:IAO_0000115 "Syndactyly with fusion of toes two to four." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasAlternativeId "HP:0005642", "HP:0005708" ; oboInOwl:hasDbXref "UMLS:C4021234" ; oboInOwl:hasExactSynonym "Syndactyly of toes 2, 3 and 4", "Syndactyly toes 2-4", "Webbed 2nd-4th toes" ; oboInOwl:id "HP:0010714" ; a owl:Class ; rdfs:label "2-4 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004691 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009779 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010715 obo:IAO_0000115 "Syndactyly with fusion of toes two to five." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023724" ; oboInOwl:hasExactSynonym "Webbed 2nd-5th toes" ; oboInOwl:id "HP:0010715" ; a owl:Class ; rdfs:label "2-5 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004692 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010716 obo:IAO_0000115 "Syndactyly with fusion of toes three to five." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023723" ; oboInOwl:hasExactSynonym "Webbed 3rd-5th toes" ; oboInOwl:id "HP:0010716" ; a owl:Class ; rdfs:label "3-5 toe syndactyly" ; rdfs:subClassOf obo:HP_0001770 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0004692 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0009779 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010717 obo:IAO_0000115 "Webbing or fusion of the toes, involving soft parts and including fusion of individual bones of the toes. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a tibial-fibular axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\"." ; dcterms:creator ; oboInOwl:creation_date "2010-03-26T05:31:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:32113001", "SNOMEDCT_US:38859008", "UMLS:C0158738" ; oboInOwl:hasExactSynonym "Osseous syndactyly of the toes" ; oboInOwl:id "HP:0010717" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Osseous syndactyly of toes" ; rdfs:subClassOf obo:HP_0001770 . obo:HP_0010719 obo:IAO_0000115 "An abnormality of the texture of the hair." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T09:41:53Z" ; oboInOwl:hasAlternativeId "HP:0002295", "HP:0003776" ; oboInOwl:hasDbXref "UMLS:C4023722", "UMLS:C4072880", "UMLS:C4072881", "UMLS:C4073290" ; oboInOwl:hasExactSynonym "Abnormality of hair texture" ; oboInOwl:hasNarrowSynonym "Abnormality of hair consistency", "Abnormality of hair curl pattern", "Abnormality of hair volume" ; oboInOwl:id "HP:0010719" ; a owl:Class ; rdfs:label "Abnormality of hair texture" ; rdfs:subClassOf obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000150 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010720 obo:IAO_0000115 "An abnormality of the distribution of hair growth." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T09:53:15Z" ; oboInOwl:hasDbXref "UMLS:C4023721" ; oboInOwl:hasExactSynonym "Abnormal distribution of hair", "Abnormal hair pattern" ; oboInOwl:id "HP:0010720" ; a owl:Class ; rdfs:label "Abnormal hair pattern" ; rdfs:subClassOf obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000060 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010721 obo:IAO_0000115 "An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair)." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T10:05:04Z" ; oboInOwl:hasDbXref "UMLS:C3280303" ; oboInOwl:hasExactSynonym "Abnormal hair whorl", "Abnormal hair whorls", "Abnormal whorl of hair" ; oboInOwl:id "HP:0010721" ; a owl:Class ; rdfs:label "Abnormal hair whorl" ; rdfs:subClassOf obo:HP_0011361 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010722 obo:IAO_0000115 "An asymmetriy, i.e., difference in size, shape or position between the left and right ear." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T10:11:45Z" ; oboInOwl:hasDbXref "UMLS:C1168239" ; oboInOwl:hasExactSynonym "Asymmetric ears" ; oboInOwl:id "HP:0010722" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the ears" ; rdfs:subClassOf obo:HP_0000357, obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010723 dcterms:creator ; oboInOwl:creation_date "2010-04-20T10:17:01Z" ; oboInOwl:hasAlternativeId "HP:0008557" ; oboInOwl:hasDbXref "UMLS:C4023720" ; oboInOwl:id "HP:0010723" ; a owl:Class ; rdfs:label "Cystic lesions of the pinnae" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0010724 obo:IAO_0000115 "An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T10:38:57Z" ; oboInOwl:hasDbXref "UMLS:C4021828" ; oboInOwl:id "HP:0010724" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Advanced pneumatization of the mastoid process" ; rdfs:subClassOf obo:HP_0000264 . obo:HP_0010726 obo:IAO_0000115 "Abnormal prominence of the corneal nerve fibers." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T10:52:24Z" ; oboInOwl:hasDbXref "UMLS:C4021233" ; oboInOwl:hasExactSynonym "Prominent corneal nerve fibres", "Visible corneal nerve fibers", "Visible corneal nerve fibres" ; oboInOwl:id "HP:0010726" ; a owl:Class ; rdfs:label "Prominent corneal nerve fibers" ; rdfs:subClassOf obo:HP_0011492 . obo:HP_0010727 obo:IAO_0000115 "Rupture of the eyeball not due to trauma." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T11:05:28Z" ; oboInOwl:hasDbXref "UMLS:C4023719" ; oboInOwl:id "HP:0010727" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Spontaneous rupture of the globe" ; rdfs:subClassOf obo:HP_0012372 . obo:HP_0010728 obo:IAO_0000115 "A developmental defect characterized by absence of the retina." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T11:09:59Z" ; oboInOwl:hasDbXref "UMLS:C4023718" ; oboInOwl:hasExactSynonym "Absent retina" ; oboInOwl:id "HP:0010728" ; a owl:Class ; rdfs:label "Aplasia of the retina" ; rdfs:subClassOf obo:HP_0008061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010729 obo:IAO_0000115 "Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparancy of the macula." ; dcterms:creator ; oboInOwl:creation_date "2010-04-20T11:14:11Z" ; oboInOwl:hasDbXref "UMLS:C2216370" ; oboInOwl:hasExactSynonym "Macular cherry red spot" ; oboInOwl:id "HP:0010729" ; a owl:Class ; rdfs:label "Cherry red spot of the macula" ; rdfs:subClassOf obo:HP_0000630 . obo:HP_0010730 obo:IAO_0000115 "This may present as a partial or complete duplication of the eyebrows." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T04:16:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253209004", "UMLS:C0431449" ; oboInOwl:hasExactSynonym "Double eyebrow", "Duplication of eyebrow" ; oboInOwl:id "HP:0010730" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Double eyebrow is commonly a feature of Mowat Wilson syndrome." ; rdfs:label "Double eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010731 obo:IAO_0000115 "The eyebrows extend towards - or even all the way down to - the margin of the upper eyelid." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T04:46:32Z" ; oboInOwl:hasDbXref "UMLS:C4023717" ; oboInOwl:hasExactSynonym "Extension of eyebrows towards upper eyelid" ; oboInOwl:id "HP:0010731" ; a owl:Class ; rdfs:comment "This is commonly a feature of Jacobson syndrome." ; rdfs:label "Extension of eyebrows towards upper eyelid" ; rdfs:subClassOf obo:HP_0011229 . obo:HP_0010732 obo:IAO_0000115 "Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T05:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4023716" ; oboInOwl:hasExactSynonym "Eyelid nodules" ; oboInOwl:id "HP:0010732" ; a owl:Class ; rdfs:label "Nodular changes affecting the eyelids" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0200036 . obo:HP_0010733 obo:IAO_0000115 "Naevus flammeus localised in the skin of the eyelid." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T05:18:41Z" ; oboInOwl:hasDbXref "UMLS:C1854409" ; oboInOwl:hasExactSynonym "Port-wine stain on eyelid" ; oboInOwl:id "HP:0010733" ; a owl:Class ; rdfs:label "Naevus flammeus of the eyelid" ; rdfs:subClassOf obo:HP_0001052 . obo:HP_0010734 obo:IAO_0000115 "Tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone or bones may be involved. Fibrous dysplasia can either effect isolated bones (Monostotic fibrous dysplasia) or also generalized all bones of the body (Polyostotic fibrous dysplasia)." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T06:27:42Z" ; oboInOwl:hasDbXref "MSH:D005357", "SNOMEDCT_US:10623005", "UMLS:C0016063" ; oboInOwl:id "HP:0010734" ; a owl:Class ; rdfs:label "Fibrous dysplasia of the bones" ; rdfs:subClassOf obo:HP_0003330 . obo:HP_0010735 obo:IAO_0000115 "Fibrous dysplasia of the bones were lesions are localized in many bones throughout of the body. Polyostotic fibrous dysplasia is a cardinal feature of McCune-Albright syndrome." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T06:31:50Z" ; oboInOwl:hasDbXref "MSH:D005359", "SNOMEDCT_US:36517007", "UMLS:C0016065" ; oboInOwl:id "HP:0010735" ; a owl:Class ; rdfs:label "Polyostotic fibrous dysplasia" ; rdfs:subClassOf obo:HP_0010734 . obo:HP_0010736 obo:IAO_0000115 "Fibrous dysplasia of the bones were lesions are localized in only one bone." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T06:31:50Z" ; oboInOwl:hasDbXref "MSH:D005358", "SNOMEDCT_US:89859004", "UMLS:C0016064" ; oboInOwl:id "HP:0010736" ; a owl:Class ; rdfs:label "Monostotic fibrous dysplasia" ; rdfs:subClassOf obo:HP_0010734 . obo:HP_0010739 obo:IAO_0000115 "Osteopoikilosis is a benign, asymptomatic sclerotic dysplasia of the bones. It affects both male and female and may be seen at any age. Radiographically sclerotic circular or ovoid lesions are usually symmetrically distributed in a periarticular location. Lesions can increase or decrease in size and number in serial radiographs or even disappear and do not have increased bone radiotracer uptake." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T07:19:11Z" ; oboInOwl:hasDbXref "MSH:D010023", "SNOMEDCT_US:9147009", "UMLS:C0029455" ; oboInOwl:id "HP:0010739" ; a owl:Class ; rdfs:label "Osteopoikilosis" ; rdfs:subClassOf obo:HP_0011001 . obo:HP_0010740 obo:IAO_0000115 "A lamellar pattern visible on radiographs and mainly localized at the metaphyses of the long tubular bones. Pathologic-anatomical studies revealed that these benign signs on x-rays are the result of a juvenile metaphyseal bone necrosis. Calcifications in the necrotic marrow lead to this lamellar or lattice-like appearance." ; dcterms:creator ; oboInOwl:creation_date "2010-04-21T07:30:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:82663009", "UMLS:C0265513" ; oboInOwl:id "HP:0010740" ; a owl:Class ; rdfs:label "Osteopathia striata" ; rdfs:subClassOf obo:HP_0031367 . obo:HP_0010741 obo:IAO_0000115 "An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg." ; dcterms:creator ; oboInOwl:creation_date "2010-04-22T02:16:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:102572006", "UMLS:C0235886", "UMLS:C0239340" ; oboInOwl:hasExactSynonym "Edema of the lower limbs", "Fluid accumulation in lower limbs", "Leg edema", "Leg oedema", "Lower leg swelling", "Oedema of the lower limbs", "Pedal oedema", "Peripheral edema of lower extremity", "Peripheral oedema of lower extremity" ; oboInOwl:hasRelatedSynonym "Dependant edema", "Dependant oedema" ; oboInOwl:id "HP:0010741" ; a owl:Class ; rdfs:label "Pedal edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010742 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin of the arms." ; dcterms:creator ; oboInOwl:creation_date "2010-04-22T02:17:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:102558002", "UMLS:C0522035" ; oboInOwl:hasExactSynonym "Fluid accumulation in upper limbs", "Oedema of the upper limbs" ; oboInOwl:id "HP:0010742" ; a owl:Class ; rdfs:label "Edema of the upper limbs" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010743 obo:IAO_0000115 "Diminished length of a metatarsal bone, with resultant proximal displacement of the associated toe." ; dcterms:creator ; oboInOwl:creation_date "2010-04-22T04:30:18Z" ; oboInOwl:hasAlternativeId "HP:0001779", "HP:0001865", "HP:0003092", "HP:0004706", "HP:0005754" ; oboInOwl:hasDbXref "UMLS:C1849020" ; oboInOwl:hasExactSynonym "Hypoplasia of the metatarsal bones", "Hypoplastic metatarsals", "Short long bone of foot", "Short metatarsal bone", "Short metatarsals", "Shortened metatarsals" ; oboInOwl:hasRelatedSynonym "Short metatarsal bones" ; oboInOwl:id "HP:0010743" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is a subjective assessment and one generally compares the position of the MTP joint to that of the contralateral digit or the putatively shortened ray in proportion to the other rays. The affected digits should be specified." ; rdfs:label "Short metatarsal" ; rdfs:subClassOf obo:HP_0001964, obo:HP_0003026, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010744 obo:IAO_0000115 "A developmental abnormality characterized by the absence (aplasia) of a metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2010-04-22T04:30:18Z" ; oboInOwl:hasDbXref "UMLS:C4021232" ; oboInOwl:hasExactSynonym "Absent long bone of foot", "Aplasia of the metatarsal bones" ; oboInOwl:id "HP:0010744" ; a owl:Class ; rdfs:label "Absent metatarsal bone" ; rdfs:subClassOf obo:HP_0001964 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010745 obo:IAO_0000115 "Absence of a digit or of one or more phalanges of a toe." ; dcterms:creator ; oboInOwl:creation_date "2010-04-22T04:33:06Z" ; oboInOwl:hasDbXref "UMLS:C4021231" ; oboInOwl:hasExactSynonym "Absent bones of the toes", "Aphalangia of the toes" ; oboInOwl:id "HP:0010745" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the toes" ; rdfs:subClassOf obo:HP_0009817, obo:HP_0010173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010746 dcterms:creator ; oboInOwl:creation_date "2010-04-22T04:33:06Z" ; oboInOwl:hasDbXref "UMLS:C4023715" ; oboInOwl:hasExactSynonym "Small toe bones" ; oboInOwl:id "HP:0010746" ; a owl:Class ; rdfs:label "Hypoplasia of the phalanges of the toes" ; rdfs:subClassOf obo:HP_0010173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010747 obo:IAO_0000115 "An abnormal distribution of eyebrow hair growth in the medial direction." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T09:29:58Z" ; oboInOwl:hasDbXref "UMLS:C1844562" ; oboInOwl:hasExactSynonym "Medially flared eyebrows" ; oboInOwl:id "HP:0010747" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Medial flaring of the eyebrow" ; rdfs:subClassOf obo:HP_0000534 . obo:HP_0010748 obo:IAO_0000115 "Positioning of a lacrimal punctum other than at the medial margins of the eyelid." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T09:35:56Z" ; oboInOwl:hasDbXref "UMLS:C4021230" ; oboInOwl:hasExactSynonym "Abnormal position of the lacrimal punctum" ; oboInOwl:id "HP:0010748" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The openings of the tear ducts are normally located at the medial margin of each eyelid. The opening on the lower eyelid border is more visible than the opening on the upper eyelid border. Ectopic positions can include the upper eyelid, nasal bridge, or inferior to medial aspect of the lower lid." ; rdfs:label "Ectopic lacrimal punctum" ; rdfs:subClassOf obo:HP_0011479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010284 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010749 obo:IAO_0000115 "Blepharochalasis is characterized by recurrent, non-painful, nonerythematous episodes of eyelid edema. It has been divided into hypertrophic and atrophic forms. In the hypertrophic form recurrent edema results in orbital fat herniation through a weakened orbital septum. Most patients who have blepharochalasis present in an atrophic condition with atrophy of redundant eyelid skin and superior nasal fat pads." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T09:53:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:47704002", "UMLS:C0005742" ; oboInOwl:hasExactSynonym "Saggy upper eyelid skin" ; oboInOwl:id "HP:0010749" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Most patients who have blepharochalasis present in an atrophic condition with atrophy of redundant eyelid skin and superior nasal fat pads. Most of these atrophic patients do not go through a hypertrophic phase. Multiple attacks of eyelid edema result in thinning, stretching, and atrophy of eyelid tissues. The eyelid skin becomes redundant, discolored, and atrophic, appearing like wrinkled cigarette paper. The upper eyelids are more commonly affected, but the lower eyelids may also be involved. Blepharochalasis is not synonymous with dermatochalasis." ; rdfs:label "Blepharochalasis" ; rdfs:subClassOf obo:HP_0100540 . obo:HP_0010750 obo:IAO_0000115 "Loss of elasticity of the upper and lower eyelids causing the skin to sag and bulge." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:07:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:246815009", "UMLS:C0423124", "UMLS:C2674149" ; oboInOwl:hasExactSynonym "Baggy eyes", "Droopy eyelid skin", "Extra eyelid skin", "Eyelid dermatochalasia", "Redundant eyelid skin" ; oboInOwl:hasRelatedSynonym "Hooding of eyelids" ; oboInOwl:id "HP:0010750" ; a owl:Class ; rdfs:label "Dermatochalasis" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0010751 obo:IAO_0000115 "A persistent midline depression of the skin over the fat pad of the chin." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:29:03Z" ; oboInOwl:hasDbXref "UMLS:C1849227" ; oboInOwl:hasExactSynonym "Chin butt", "Chin dent", "Chin dimple", "Chin skin dimple", "Dimple chin", "Gelasin of chin", "Indentation of chin" ; oboInOwl:hasRelatedSynonym "Chin dimples" ; oboInOwl:id "HP:0010751" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Dimple chin" ; rdfs:subClassOf obo:HP_0000306 . obo:HP_0010752 obo:IAO_0000115 "Midline deficiency of the mandible and some or all overlying tissues." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:32:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:92822004", "UMLS:C0685786" ; oboInOwl:hasExactSynonym "Cleft lower jaw", "Mandibular cleft" ; oboInOwl:id "HP:0010752" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cleft mandible" ; rdfs:subClassOf obo:HP_0010753 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001786 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010753 dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:32:46Z" ; oboInOwl:hasDbXref "UMLS:C4023714" ; oboInOwl:hasExactSynonym "Midline cleft of mandible" ; oboInOwl:id "HP:0010753" ; a owl:Class ; rdfs:label "Midline defect of mandible" ; rdfs:subClassOf obo:HP_0000277 . obo:HP_0010754 obo:IAO_0000115 "An anomaly of the temporomandibular joint." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:36:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:248401009", "SNOMEDCT_US:75630004", "UMLS:C0266941", "UMLS:C0424721", "UMLS:C1865318", "UMLS:C4280366" ; oboInOwl:hasExactSynonym "Abnormality of the jaw joint", "Anomaly of the temporomandibular joint", "Deformity of the jaw joint", "Malformation of jaw joint" ; oboInOwl:hasNarrowSynonym "Deformity of the temporomandibular joint", "Derangement of the temporomandibular joint", "Malformation of the temporomandibular joint" ; oboInOwl:id "HP:0010754" ; a owl:Class ; rdfs:label "Abnormality of the temporomandibular joint" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003700 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010755 obo:IAO_0000115 "Asymmetry between the left and right sides of the maxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:38:44Z" ; oboInOwl:hasBroadSynonym "Asymmetry of the upper jaw", "Asymmetry of upper jaw", "Crooked upper jaw" ; oboInOwl:hasDbXref "SNOMEDCT_US:235083001", "UMLS:C0399519" ; oboInOwl:hasExactSynonym "Asymmetry of right and left side of the maxilla", "Canted maxilla", "Canted upper jaw", "Crooked maxilla", "Tilted maxilla", "Tilted upper jaw", "Unequal sides of maxilla", "Uneven maxilla", "Uneven upper jaw" ; oboInOwl:hasRelatedSynonym "Deviation of the maxilla", "Deviation of the upper jaw" ; oboInOwl:id "HP:0010755" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Asymmetry of the maxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010756 obo:IAO_0000115 "Absence or underdevelopment of the premaxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:40:40Z" ; oboInOwl:hasDbXref "UMLS:C4023713" ; oboInOwl:hasExactSynonym "Aplasia/hypoplasia of the intermaxillary bone", "Aplasia/hypoplasia of the primary palate bone" ; oboInOwl:id "HP:0010756" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the premaxilla" ; rdfs:subClassOf obo:HP_0010758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010757 obo:IAO_0000115 "Absence of the premaxilla, which is the embryonic structure that forms the anterior part of the maxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:42:17Z" ; oboInOwl:hasDbXref "UMLS:C4023712" ; oboInOwl:hasExactSynonym "Absence of the intermaxillary bone", "Absence of the premaxilla", "Absence of the primary palate bone", "Aplasia of the intermaxillary bone", "Aplasia of the primary palate bone", "Failure of development of premaxilla", "Failure of development of the primary palate bone", "Missing premaxilla", "Missing primary palate bone" ; oboInOwl:id "HP:0010757" ; a owl:Class ; rdfs:label "Aplasia of the premaxilla" ; rdfs:subClassOf obo:HP_0010756, obo:HP_0040008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010758 obo:IAO_0000115 "An abnormality of the premaxilla, the most anterior part of the maxilla that usually bears the central and lateral incisors and includes the anterior nasal spine and inferior aspect of the piriform rim. The premaxilla contains the bone and teeth of the primary palate." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T10:59:07Z" ; oboInOwl:hasDbXref "UMLS:C4023711" ; oboInOwl:hasExactSynonym "Abnormality of the intermaxillary bone", "Abnormality of the intermaxillary segment of the maxilla", "Abnormality of the premaxillary bone", "Abnormality of the primary palate bone" ; oboInOwl:id "HP:0010758" ; a owl:Class ; rdfs:label "Abnormality of the premaxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010759 obo:IAO_0000115 "Prominent positioning of the premaxilla in relation to the rest of the maxilla, the facial skeleton, or mandible. Not necessarily caused by an increase in size (hypertrophy of) the premaxilla." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T11:01:23Z" ; oboInOwl:hasDbXref "UMLS:C2749369" ; oboInOwl:hasExactSynonym "Anterior position of the premaxilla", "Anterior position of the primary palate bone", "Premaxillary bone excess", "Prominence of the intermaxillary bone", "Prominence of the primary palate bone", "Prominent premaxilla" ; oboInOwl:id "HP:0010759" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "As a consequence of prominence of the premaxilla, the overlying structures, the nose and philtrum, may appear prominent. There is increased convexity of the face and an increased nasolabial angle. In the presence of a normal sized mandible, retrognathia may be appreciated." ; rdfs:label "Prominence of the premaxilla" ; rdfs:subClassOf obo:HP_0010758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010760 obo:IAO_0000115 "Aplasia of a toe. That is, absence of all phalanges of a non-hallux digit of the foot and the associated soft tissues." ; dcterms:creator ; oboInOwl:creation_date "2010-04-23T03:58:25Z" ; oboInOwl:hasAlternativeId "HP:0008084", "HP:0010108", "HP:0011306" ; oboInOwl:hasDbXref "UMLS:C3553754" ; oboInOwl:hasExactSynonym "Absent toe", "Aplasia of toe" ; oboInOwl:hasRelatedSynonym "Absent toes", "Aplasia of the toes" ; oboInOwl:id "HP:0010760" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This descriptor does NOT require absence of the metatarsal. The definition excludes partial absent hallux." ; rdfs:label "Absent toe" ; rdfs:subClassOf obo:HP_0001991 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010761 obo:IAO_0000115 "Increased width of the columella." ; dcterms:creator ; oboInOwl:creation_date "2010-04-24T11:52:54Z" ; oboInOwl:hasDbXref "UMLS:C1851059", "UMLS:C4280365" ; oboInOwl:hasExactSynonym "Columella, broad", "Columella, wide", "Fullness of columella", "Increased width of columella" ; oboInOwl:hasRelatedSynonym "Hyperplasia of columella" ; oboInOwl:id "HP:0010761" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad columella" ; rdfs:subClassOf obo:HP_0009929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002359 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008341 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010762 obo:IAO_0000115 "A chordoma is a tumor that arises from embryonic remnants of the notochord along the length of the neuraxis. Chordomas generally occur in the sacrum, intracranially at the clivus, or along the spinal axis." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T09:00:39Z" ; oboInOwl:hasDbXref "MSH:D002817", "NCIT:C2947", "SNOMEDCT_US:50007008", "UMLS:C0008487" ; oboInOwl:id "HP:0010762" ; a owl:Class ; rdfs:comment "The notochord is a mesodermal embryonic structure that defines the primitive axis of the embryo and which survives in the adult vertebral column as the intervertebral disks." ; rdfs:label "Chordoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0010763 obo:IAO_0000115 "Insertion of the posterior columella below the nasal base." ; dcterms:creator ; oboInOwl:creation_date "2010-04-24T12:12:25Z" ; oboInOwl:hasBroadSynonym "Ala higher than columella" ; oboInOwl:hasDbXref "UMLS:C4021229", "UMLS:C4280364" ; oboInOwl:hasExactSynonym "Columella, low insertion" ; oboInOwl:id "HP:0010763" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature is different from a convex Low hanging columella that has a normal insertion. It may be associated with a Short philtrum, but this should be assessed and coded separately. A low insertion is best appreciated when viewed from the side." ; rdfs:label "Low insertion of columella" ; rdfs:subClassOf obo:HP_0009929 . obo:HP_0010764 obo:IAO_0000115 "Decreased length of the eyelashes (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2010-04-24T03:31:00Z" ; oboInOwl:hasDbXref "UMLS:C2748682" ; oboInOwl:hasExactSynonym "Decreased length of eyelashes", "Short eyelashes" ; oboInOwl:id "HP:0010764" ; a owl:Class ; rdfs:comment "Normal values are 7.99 - 1.05 mm in boys and 7.76 - 1.03 mm in girls." ; rdfs:label "Short eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010765 obo:IAO_0000115 "Abnormal thickening of the skin localized to the palm of the hand." ; dcterms:creator ; oboInOwl:creation_date "2010-04-24T03:53:19Z" ; oboInOwl:hasDbXref "UMLS:C4023710" ; oboInOwl:id "HP:0010765" ; a owl:Class ; rdfs:label "Palmar hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0040211 . obo:HP_0010766 obo:IAO_0000115 "Deposition of calcium salts in a tissue or location in which calcification does not normally occur." ; dcterms:creator ; oboInOwl:creation_date "2010-04-27T09:52:59Z" ; oboInOwl:hasDbXref "UMLS:C3806226" ; oboInOwl:id "HP:0010766" ; a owl:Class ; rdfs:label "Ectopic calcification" ; rdfs:subClassOf obo:HP_0000924 . obo:HP_0010767 obo:IAO_0000115 "The presence of a cyst, fistula, or abscess in the sacrococcygeal region (gluteal crease) characteristically accompanied by hair and skin folds." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T09:45:21Z" ; oboInOwl:hasDbXref "UMLS:C4023709" ; oboInOwl:id "HP:0010767" ; a owl:Class ; rdfs:label "Sacrococcygeal pilonidal abnormality" ; rdfs:subClassOf obo:HP_0005107 . obo:HP_0010769 obo:IAO_0000115 "A sinus in the coccygeal region (the region of the intergluteal cleft). A pilonidal sinus often contains hair and skin debris." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T09:55:15Z" ; oboInOwl:hasAlternativeId "HP:0010768" ; oboInOwl:hasDbXref "MSH:D010864", "SNOMEDCT_US:47639008", "UMLS:C0031925" ; oboInOwl:hasExactSynonym "Pilonidal cyst" ; oboInOwl:id "HP:0010769" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pilonidal sinus" ; rdfs:subClassOf obo:HP_0010767 . obo:HP_0010770 dcterms:creator ; oboInOwl:creation_date "2010-04-29T09:55:15Z" ; oboInOwl:hasDbXref "MSH:D010864", "SNOMEDCT_US:47639008", "UMLS:C0031925" ; oboInOwl:id "HP:0010770" ; a owl:Class ; rdfs:label "Pilonidal fistula" ; rdfs:subClassOf obo:HP_0010767 . obo:HP_0010771 obo:IAO_0000115 "A hair-containing cyst or sinus usually in the coccygeal region." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T09:55:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:85224001", "UMLS:C3537055" ; oboInOwl:hasExactSynonym "Sacrococcygeal fistula" ; oboInOwl:id "HP:0010771" ; a owl:Class ; rdfs:label "Pilonidal abscess" ; rdfs:subClassOf obo:HP_0010767, obo:HP_0031292 . obo:HP_0010772 obo:IAO_0000115 "A developmental defect characterized by abnormal connection of one or more pulmonary veins to the superior or inferior vena cava, the right atrium, or the coronary sinus, resulting in a left-to-right shunt of oxygenated blood." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:02:26Z" ; oboInOwl:hasDbXref "MSH:D012587", "SNOMEDCT_US:111323005", "SNOMEDCT_US:39905002", "UMLS:C0036400" ; oboInOwl:id "HP:0010772" ; a owl:Class ; rdfs:label "Anomalous pulmonary venous return" ; rdfs:subClassOf obo:HP_0030968 . obo:HP_0010773 obo:IAO_0000115 "A form of anomalous pulmonary venous return in which not all pulmonary veins drain abnormally. Partial anomalous pulmonary venous return frequently involves one or both of the veins from one lung." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:03:02Z" ; oboInOwl:hasDbXref "Fyler:2030", "SNOMEDCT_US:68237008", "UMLS:C0158634" ; oboInOwl:hasExactSynonym "Partial anomalous pulmonary venous connection" ; oboInOwl:id "HP:0010773" ; a owl:Class ; rdfs:label "Partial anomalous pulmonary venous return" ; rdfs:subClassOf obo:HP_0010772 . obo:HP_0010774 obo:IAO_0000115 "The presence of an additional membrane in the left or right cardiac atrium which results in the subdivision of the affected atrium (and thus in total three atria, whence the name)." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:07:24Z" ; oboInOwl:hasDbXref "Fyler:3031", "ICD-10:Q24.2", "UMLS:C4023708" ; oboInOwl:hasExactSynonym "Triatrial heart" ; oboInOwl:id "HP:0010774" ; a owl:Class ; rdfs:label "Cor triatriatum" ; rdfs:subClassOf obo:HP_0005120 . obo:HP_0010775 obo:IAO_0000115 "A developmental defect of the aortic arch system in which the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches. This occurs if the normal process of regression and persistence of the bilateral embryonic aortic arches fails." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:18:47Z" ; oboInOwl:hasDbXref "Fyler:2760", "SNOMEDCT_US:110409004", "SNOMEDCT_US:66403007", "UMLS:C0221214" ; oboInOwl:hasExactSynonym "Vascular ring of aorta" ; oboInOwl:id "HP:0010775" ; a owl:Class ; rdfs:label "Vascular ring" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0010776 obo:IAO_0000115 "Marked widening of the trachea and major bronchi that may be predispose to chronic respiratory tract infection." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:22:55Z" ; oboInOwl:hasDbXref "UMLS:C4023707" ; oboInOwl:id "HP:0010776" ; a owl:Class ; rdfs:comment "Tracheobronchmegaly is typically characterized by atrophy or absence of elastic fibers and thinning of smooth muscle layers in the trachea and main bronchi." ; rdfs:label "Tracheobronchmegaly" ; rdfs:subClassOf obo:HP_0010777, obo:HP_0010778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010777 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:HP_0010778 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010777 obo:IAO_0000115 "Marked widening of the major bronchi that may be predispose to chronic respiratory tract infection." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:25:22Z" ; oboInOwl:hasDbXref "UMLS:C4023706" ; oboInOwl:id "HP:0010777" ; a owl:Class ; rdfs:label "Bronchomegaly" ; rdfs:subClassOf obo:HP_0025426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002185 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010778 obo:IAO_0000115 "Marked widening of the trachea." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T10:28:51Z" ; oboInOwl:hasDbXref "UMLS:C4023705" ; oboInOwl:id "HP:0010778" ; a owl:Class ; rdfs:label "Tracheomegaly" ; rdfs:subClassOf obo:HP_0002778 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010779 obo:IAO_0000115 "The presence of an abnormally large pelvis." ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T11:03:39Z" ; oboInOwl:hasBroadSynonym "Large pelvis" ; oboInOwl:hasDbXref "UMLS:C4019074", "UMLS:C4072882" ; oboInOwl:hasExactSynonym "Large pelvis bone" ; oboInOwl:id "HP:0010779" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Large pelvis bone" ; rdfs:subClassOf obo:HP_0040163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010780 obo:IAO_0000115 "Over-sensitivity to certain frequency ranges of sound." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2010-04-29T04:42:44Z" ; oboInOwl:hasDbXref "MSH:D012001", "SNOMEDCT_US:194399009", "SNOMEDCT_US:25289003", "UMLS:C0034880" ; oboInOwl:id "HP:0010780" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hyperacusis refers to a general hypersensitivity to sound of any frequency, and phonophobia to an anxious sensitivity towards specific sound largely independent of its volume. Hyperacusis and phonophobia represent disturbances of central auditory processing without peripheral pathology, often combined with psychosomatic reactions. Listeners with hearing loss often struggle to detect low-level sounds, but as the sound intensity rises above threshold, loudness initially grows at a faster than normal rate, but the growth rate slows with increasing intensity so that normal loudness is achieved at high intensities. This phenomenon is referred to as loudness recruitment. However, in some hearing-impaired listeners,loudness continues to grow more rapidly than normal at suprathreshold intensities causing moderately intense sounds to be perceived as louder than normal, a debilitating condition known as hyperacusis or loudness intolerance." ; rdfs:label "Hyperacusis" ; rdfs:subClassOf obo:HP_5200060 . obo:HP_0010781 obo:IAO_0000115 "Skin dimples are cutaneous indentations that are the result of tethering of the skin to underlying structures (bone) causing an indentation." ; dcterms:creator ; oboInOwl:creation_date "2010-04-30T11:34:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:301854006", "UMLS:C0578531" ; oboInOwl:hasExactSynonym "Skin dimples" ; oboInOwl:id "HP:0010781" ; a owl:Class ; rdfs:label "Skin dimple" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0010782 obo:IAO_0000115 "A subtype of skin dimples occurring in the shoulder region." ; dcterms:creator ; oboInOwl:creation_date "2010-04-30T11:36:51Z" ; oboInOwl:hasDbXref "UMLS:C4023704" ; oboInOwl:hasExactSynonym "Acromial dimple", "Bi-acromial dimples", "Shoulder dimples" ; oboInOwl:id "HP:0010782" ; a owl:Class ; rdfs:comment "Symmetrical dimples of the skin overlying the acromial process of the scapulae are called bi-acromial dimples." ; rdfs:label "Shoulder dimple" ; rdfs:subClassOf obo:HP_0010781 . obo:HP_0010783 obo:IAO_0000115 "Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin." ; dcterms:creator ; oboInOwl:creation_date "2010-04-30T11:40:43Z" ; oboInOwl:hasDbXref "MSH:D004890", "MSH:D005483", "SNOMEDCT_US:20255002", "SNOMEDCT_US:238810007", "SNOMEDCT_US:247441003", "SNOMEDCT_US:271811009", "SNOMEDCT_US:444827008", "SNOMEDCT_US:70819003", "SNOMEDCT_US:86735004", "UMLS:C0016382", "UMLS:C0041834" ; oboInOwl:hasExactSynonym "Redness of skin or mucous membrane" ; oboInOwl:id "HP:0010783" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Erythema" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0010784 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the uterus." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:35:15Z" ; oboInOwl:hasBroadSynonym "Uterine cancer" ; oboInOwl:hasDbXref "MSH:D014594", "NCIT:C3262", "SNOMEDCT_US:126908007", "UMLS:C0042138" ; oboInOwl:hasExactSynonym "Uterine tumor", "Uterine tumour" ; oboInOwl:hasRelatedSynonym "Uterine neoplasia" ; oboInOwl:id "HP:0010784" ; a owl:Class ; rdfs:label "Uterine neoplasm" ; rdfs:subClassOf obo:HP_0031105, obo:HP_0033020 . obo:HP_0010785 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of a gonad." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:44:41Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4021228" ; oboInOwl:hasExactSynonym "Gonadal neoplasia" ; oboInOwl:id "HP:0010785" ; a owl:Class ; rdfs:label "Gonadal neoplasm" ; rdfs:subClassOf obo:HP_0010787 . obo:HP_0010786 obo:IAO_0000115 "The presence of a neoplasm of the urinary system." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:45:25Z" ; oboInOwl:hasDbXref "MSH:D014571", "NCIT:C3262", "SNOMEDCT_US:126879004", "SNOMEDCT_US:254913005", "UMLS:C0042076" ; oboInOwl:hasRelatedSynonym "Urinary tract neoplasia" ; oboInOwl:id "HP:0010786" ; a owl:Class ; rdfs:label "Urinary tract neoplasm" ; rdfs:subClassOf obo:HP_0007379 . obo:HP_0010787 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the genital system." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:47:50Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C0679347", "UMLS:C4020767" ; oboInOwl:hasExactSynonym "Genital tumor", "Genital tumour" ; oboInOwl:hasRelatedSynonym "Genital neoplasia" ; oboInOwl:id "HP:0010787" ; a owl:Class ; rdfs:label "Genital neoplasm" ; rdfs:subClassOf obo:HP_0000078, obo:HP_0007379 . obo:HP_0010788 obo:IAO_0000115 "The presence of a neoplasm of the testis." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:48:35Z" ; oboInOwl:hasBroadSynonym "Testicular cancer" ; oboInOwl:hasDbXref "MSH:D013736", "NCIT:C3262", "SNOMEDCT_US:126900000", "UMLS:C0039590" ; oboInOwl:hasExactSynonym "Testicular tumor", "Testicular tumour" ; oboInOwl:hasRelatedSynonym "Testicular neoplasia" ; oboInOwl:id "HP:0010788" ; a owl:Class ; rdfs:label "Testicular neoplasm" ; rdfs:subClassOf obo:HP_0000035, obo:HP_0010785, obo:HP_0100848 . obo:HP_0010789 dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:50:45Z" ; oboInOwl:hasDbXref "UMLS:C4023703" ; oboInOwl:id "HP:0010789" ; a owl:Class ; rdfs:label "Abnormality of the Leydig cells" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010790 obo:IAO_0000115 "Underdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:51:03Z" ; oboInOwl:hasDbXref "UMLS:C4023702" ; oboInOwl:id "HP:0010790" ; a owl:Class ; rdfs:label "Hyoplasia of the Leydig cells" ; rdfs:subClassOf obo:HP_0010789 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010791 obo:IAO_0000115 "Hypertrophy or overdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T09:51:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:76085008", "UMLS:C0023600" ; oboInOwl:id "HP:0010791" ; a owl:Class ; rdfs:label "Hyperplasia of the Leydig cells" ; rdfs:subClassOf obo:HP_0010789 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010793 obo:IAO_0000115 "A digit with two nails, with at least some soft tissue between them." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T10:34:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:110992006", "UMLS:C0544857" ; oboInOwl:hasExactSynonym "Notched nail", "duplicated nail" ; oboInOwl:id "HP:0010793" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bifid nail" ; rdfs:subClassOf obo:HP_0002164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010794 obo:IAO_0000115 "Reduced ability affecting mainly visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales, which test a person's strengths and weaknesses across a range of intellectual abilities)." ; dc:creator "sandra1" ; oboInOwl:creation_date "2010-05-10T01:43:01Z" ; oboInOwl:hasDbXref "UMLS:C4023701" ; oboInOwl:id "HP:0010794" ; a owl:Class ; rdfs:comment "The ability to see an object or picture as a set of parts and then to construct a replica of the original from these parts is known as visuospatial constructive cognition. Impaired visuospatial constructive cognition is one of the characteristic featrues of most patients with Williams-Beuren Syndrome." ; rdfs:label "Impaired visuospatial constructive cognition" ; rdfs:subClassOf obo:HP_0001328 . obo:HP_0010795 obo:IAO_0000115 "A glioma affecting the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T09:08:32Z" ; oboInOwl:hasDbXref "UMLS:C4023700" ; oboInOwl:id "HP:0010795" ; a owl:Class ; rdfs:label "Cerebellar glioma" ; rdfs:subClassOf obo:HP_0009733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009733 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010796 obo:IAO_0000115 "A glioma affecting the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T09:10:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:444545003", "UMLS:C0677865" ; oboInOwl:id "HP:0010796" ; a owl:Class ; rdfs:label "Brainstem glioma" ; rdfs:subClassOf obo:HP_0009733 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0009733 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002298 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010797 obo:IAO_0000115 "A hemangioblastoma is a benign vascular neoplasm that arises almost exclusively in the central nervous system. Hemangioblastomas consist of a tightly packed cluster of small blood vessels forming a mass of up to 1 or 2 cm in diameter." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T09:18:32Z" ; oboInOwl:hasDbXref "MSH:D018325", "NCIT:C3801", "SNOMEDCT_US:81201000", "UMLS:C0206734" ; oboInOwl:hasExactSynonym "Haemangioblastoma" ; oboInOwl:id "HP:0010797" ; a owl:Class ; rdfs:label "Hemangioblastoma" ; rdfs:subClassOf obo:HP_0100835 . obo:HP_0010798 obo:IAO_0000115 "Increased focal pigmentation of the vermilion of the lips." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T01:59:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:239136007", "UMLS:C0406814" ; oboInOwl:hasExactSynonym "Ephelis of lip", "Labial lentigo", "Lip freckle", "Lip lentigo" ; oboInOwl:id "HP:0010798" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Lip freckles may be accompanied by Perioral hyperpigmentation, but this should be assessed separately. Lentigo is commonly used as a synonym for freckle in reference to the vermilion, but these are distinct terms when referring to the skin." ; rdfs:label "Lip freckle" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0010799 obo:IAO_0000115 "A neoplasm of the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2010-06-25T09:27:58Z" ; oboInOwl:hasDbXref "MSH:D010871", "NCIT:C3328", "SNOMEDCT_US:127026004", "SNOMEDCT_US:359619007", "SNOMEDCT_US:47598005", "UMLS:C0031941" ; oboInOwl:id "HP:0010799" ; a owl:Class ; rdfs:label "Pinealoma" ; rdfs:subClassOf obo:HP_0030063, obo:HP_0030693 . obo:HP_0010800 obo:IAO_0000115 "Lack of paramedian peaks and median notch of the upper lip vermilion." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T02:01:31Z" ; oboInOwl:hasDbXref "UMLS:C2053435" ; oboInOwl:hasExactSynonym "Absent cupid's bow", "Agenesis of cupid's bow", "Failure of development of cupid's bow", "Lack of cupid's bow", "Missing cupid's bow" ; oboInOwl:hasRelatedSynonym "Aplasia of cupid's bow" ; oboInOwl:id "HP:0010800" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This bow is often absent in a Thin vermilion of the upper lip, but that should be assessed separately. This finding is commonly associated with Smooth philtrum, but that should be coded separately." ; rdfs:label "Absent cupid's bow" ; rdfs:subClassOf obo:HP_0011339 . obo:HP_0010801 obo:IAO_0000115 "Reduced bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion or commissure)." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T02:10:51Z" ; oboInOwl:hasDbXref "UMLS:C4021227" ; oboInOwl:hasExactSynonym "Flat nasolabial fold", "Nasolabial crease, hypoplastic", "Nasolabial crease, underdeveloped", "Nasolabial fold, hypoplastic", "Shallow nasolabial fold" ; oboInOwl:id "HP:0010801" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Underdeveloped nasolabial fold" ; rdfs:subClassOf obo:HP_0005289 . obo:HP_0010802 obo:IAO_0000115 "Increased pigmentation, either focal or generalized, of the skin surrounding the vermilion of the lips." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T02:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4023699" ; oboInOwl:hasExactSynonym "Darkening of skin around the mouth", "Increased pigmentation around the mouth" ; oboInOwl:id "HP:0010802" ; a owl:Class ; rdfs:comment "Periorbital hyperpigmentation may be accompanied by Lip freckles, but this should be assessed separately." ; rdfs:label "Perioral hyperpigmentation" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0010803 obo:IAO_0000115 "Inner aspect of the upper lip vermilion (normally apposing the teeth) visible in a frontal view, i.e., the presence of an everted upper lip." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T02:30:13Z" ; oboInOwl:hasDbXref "UMLS:C3275452", "UMLS:C4023698", "UMLS:C4280363" ; oboInOwl:hasExactSynonym "Eclabium of upper lip", "Everted prominent upper lip", "Everted upper lip", "Outward turned upper lip" ; oboInOwl:hasRelatedSynonym "Drooping upper lip", "Protruding upper lip" ; oboInOwl:id "HP:0010803" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In frontal view, with the face relaxed, the apparent height of the upper lip vermilion is excessive and the upper incisors may be visible. On profile view, the vermilion is more convex than usual. An everted upper lip may be associated with a short philtrum, and may be secondary to protruded upper teeth, but these should be assessed and described separately." ; rdfs:label "Everted upper lip vermilion" ; rdfs:subClassOf obo:HP_0011339, obo:HP_0012472 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010804 obo:IAO_0000115 "Triangular appearance of the oral aperture with the apex in the midpoint of the upper vermilion and the lower vermilion forming the base." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T02:32:35Z" ; oboInOwl:hasAlternativeId "HP:0100895" ; oboInOwl:hasDbXref "UMLS:C1839767", "UMLS:C1850072", "UMLS:C1853383" ; oboInOwl:hasExactSynonym "Inverted V-shaped upper lip" ; oboInOwl:hasRelatedSynonym "Tented mouth", "Tented upper lip" ; oboInOwl:id "HP:0010804" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is distinguished from an Exaggerated Cupid's bow by the alteration of the shape of the oral aperture." ; rdfs:label "Tented upper lip vermilion" ; rdfs:subClassOf obo:HP_0011339 . obo:HP_0010805 obo:IAO_0000115 "Oral commissures positioned superior to the midline labial fissure." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T03:17:08Z" ; oboInOwl:hasDbXref "UMLS:C3553471" ; oboInOwl:hasExactSynonym "Upturned corners of mouth", "Upturned mouth", "Upturned oral commisures" ; oboInOwl:id "HP:0010805" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding should be assessed with the mouth closed, the lips in relaxed contact, and the face relaxed. The finding may be difficult to assess if the upper lip is enlarged." ; rdfs:label "Upturned corners of mouth" ; rdfs:subClassOf obo:HP_0011338 . obo:HP_0010806 obo:IAO_0000115 "Gentle upward curve of the upper lip vermilion such that the center is placed well superior to the commissures." ; dcterms:creator ; oboInOwl:creation_date "2010-06-26T03:25:01Z" ; oboInOwl:hasAlternativeId "HP:0000186" ; oboInOwl:hasDbXref "UMLS:C1856202" ; oboInOwl:hasExactSynonym "Carp-like mouth", "Carp-shaped mouth", "Fish mouth", "Large, carp-shaped mouth", "Wide, carp-shaped mouth" ; oboInOwl:id "HP:0010806" ; a owl:Class ; rdfs:comment "The U-shaped upper vermilion is a more rounded version of the Tented upper lip vermilion. In U-shaped upper vermilion there is loss of the central groove of the Cupid's bow. Replaces: Carpmouth; Fish mouth (pejorative terms)." ; rdfs:label "U-Shaped upper lip vermilion" ; rdfs:subClassOf obo:HP_0011339 . obo:HP_0010807 obo:IAO_0000115 "Visible space between the dental arches in occlusion." ; dcterms:creator ; oboInOwl:creation_date "2010-07-02T09:30:43Z" ; oboInOwl:hasDbXref "MSH:D024343", "SNOMEDCT_US:35580009", "UMLS:C0266061" ; oboInOwl:hasExactSynonym "Absence of overlap of upper and lower teeth", "Open bite", "Open bite between upper and lower teeth" ; oboInOwl:id "HP:0010807" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "An open bite produces an absence of vertical overlap of the two dental arches. It may be associated with malocclusion, but this should be coded separately. Open bite can be accompanied by malocclusion, which is a complex bundled term. The Angle classification of malocclusion (Classes I-III) is widely used in the orthodontics community [Moyers, [1973]] for the characterization of malocclusion." ; rdfs:label "Open bite" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0010808 obo:IAO_0000115 "Tongue extending beyond the alveolar ridges or teeth at rest." ; dcterms:creator ; oboInOwl:creation_date "2010-07-02T09:38:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249872000", "SNOMEDCT_US:285503005", "UMLS:C0241442" ; oboInOwl:hasExactSynonym "Lingual prolapse", "Lingual prominence", "Lingual protrusion", "Prolapse of tongue", "Prominent tongue", "Protruding tongue", "Tongue protrusion", "Tongue sticking out of mouth" ; oboInOwl:id "HP:0010808" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Protruding tongue may or may not be associated with a Large tongue, and that finding should be assessed and coded separately." ; rdfs:label "Protruding tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010809 obo:IAO_0000115 "Increased width of the uvula (subjective finding)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T10:22:01Z" ; oboInOwl:hasDbXref "UMLS:C3693299" ; oboInOwl:hasExactSynonym "Wide uvula" ; oboInOwl:id "HP:0010809" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding often accompanies a Submucous cleft palate, but this should be coded separately. A longitudinal groove indicating incomplete fusion of the two parts of the uvula may be present with a broadened uvula and has sometimes been called abortive cleft uvula." ; rdfs:label "Broad uvula" ; rdfs:subClassOf obo:HP_0000172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010810 obo:IAO_0000115 "Increased length of the uvula." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T10:23:52Z" ; oboInOwl:hasBroadSynonym "Hyperplasia of uvula" ; oboInOwl:hasDbXref "UMLS:C4023697", "UMLS:C4280362" ; oboInOwl:hasExactSynonym "Long palatine uvula" ; oboInOwl:hasRelatedSynonym "Elongated uvula" ; oboInOwl:id "HP:0010810" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In clinical practice, the size of the uvula cannot be easily measured and is not static, since it depends on the position of the soft palate, the base of the tongue, and the head. Therefore, judgment of change in length of the uvula depends heavily on the experience of the observer." ; rdfs:label "Long uvula" ; rdfs:subClassOf obo:HP_0000172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010811 obo:IAO_0000115 "Decreased width of the uvula." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T10:25:14Z" ; oboInOwl:hasDbXref "UMLS:C4023696" ; oboInOwl:hasExactSynonym "Narrow palatine uvula" ; oboInOwl:hasRelatedSynonym "Thin uvula" ; oboInOwl:id "HP:0010811" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Narrow uvula" ; rdfs:subClassOf obo:HP_0000172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010812 obo:IAO_0000115 "Decreased length of the uvula." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T10:26:47Z" ; oboInOwl:hasDbXref "UMLS:C1401781" ; oboInOwl:hasExactSynonym "Hypoplastic uvula", "Short palatine uvula" ; oboInOwl:hasRelatedSynonym "Blunt uvula" ; oboInOwl:id "HP:0010812" ; a owl:Class ; rdfs:comment "Objective measurement of the length of the uvula can be determined on a lateral cephalograms. However, in this series we are not relying on radiographs for assessment of findings. In clinical practice, the size of the uvula cannot be easily measured and is not static, since it depends on the position of the soft palate, the base of the tongue, and the head. Therefore, judgment of change in length of the uvula depends heavily on the experience of the observer." ; rdfs:label "Short uvula" ; rdfs:subClassOf obo:HP_0010293 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001734 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010813 obo:IAO_0000115 "More than two clockwise hair whorls." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T11:12:26Z" ; oboInOwl:hasDbXref "UMLS:C4023695" ; oboInOwl:hasExactSynonym "Abnormal number of hair swirls", "Abnormal number of hair whorls", "Double crown (hair whorls)", "Extra hair swirls", "Extra hair whorl", "Supernumary hair swirls", "Supernumary hair whorl" ; oboInOwl:id "HP:0010813" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Most individuals have one clockwise hair whorl at a single point on the scalp lateral to the midline but close to the vertex of the skull. Five percent of the population has two whorls. A double hair whorl is sometimes referred to as a double crown. In 10%, whorl direction is counter-clockwise." ; rdfs:label "Abnormal number of hair whorls" ; rdfs:subClassOf obo:HP_0010721 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010814 obo:IAO_0000115 "Hair growth from a single point on the scalp in any location other than lateral to the midline and close to the vertex of the skull." ; dcterms:creator ; oboInOwl:creation_date "2010-07-05T11:13:42Z" ; oboInOwl:hasDbXref "UMLS:C4023694" ; oboInOwl:hasExactSynonym "Abnormal location of hair swirl", "Abnormal position of hair whorl" ; oboInOwl:id "HP:0010814" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Placement of hair whorl should be described as parietal, vertex, eccentric, etc. In addition, the number of hair whorls should be noted. Five percent of the population has two whorls." ; rdfs:label "Abnormal position of hair whorl" ; rdfs:subClassOf obo:HP_0010721 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014381 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010815 obo:IAO_0000115 "A congenital, hairless plaque consisting of overgrown epidermis, sebaceous glands, hair follicles, apocrine glands and connective tissue. They are a variant of epidermal naevi. Sebaceous naevi most often appear on the scalp, but they may also arise on the face, neck or forehead. At birth, a sevaceous nevus typically appears as a solitary, smooth, yellow-orange hairless patch. Sebaceous naevi become more pronounced around adolescence, often appearing bumpy, warty or scaly." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T12:07:03Z" ; oboInOwl:hasDbXref "MSH:D054000", "SNOMEDCT_US:239112008", "SNOMEDCT_US:52298009", "SNOMEDCT_US:707136009", "UMLS:C3854181" ; oboInOwl:hasExactSynonym "Naevus sebaceous", "Organoid nevus", "Sebaceous mole", "Sebaceous naevus", "Sebaceous nevus" ; oboInOwl:id "HP:0010815" ; a owl:Class ; rdfs:label "Nevus sebaceous" ; rdfs:subClassOf obo:HP_0010816 . obo:HP_0010816 obo:IAO_0000115 "Epidermal naevi are due to an overgrowth of the epidermis and may be present at birth (50%) or develop during childhood." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T12:12:32Z" ; oboInOwl:hasDbXref "MSH:C580062", "SNOMEDCT_US:239107007", "SNOMEDCT_US:25201003", "UMLS:C0334082" ; oboInOwl:hasRelatedSynonym "Epidermal nevi" ; oboInOwl:id "HP:0010816" ; a owl:Class ; rdfs:comment "Epidermal nevus arises from a defect in the ectoderm and in general are due to an overgrowth of keratinocytes. Subclasses of epidermal nevus include Linear epidermal naevus, epidermolytic epidermal naevus, acantholytic epidermal naevus, linear porokeratosis, and systematised epidermal naevus. Several other conditions are also characterised by benign overgrowth of the epidermis and its appendages (organoid naevi), including inflammatory linear verrucous epidermal naevus, sebaceous naevus, sweat gland naevi, comedone naevus, and Becker naevus." ; rdfs:label "Epidermal nevus" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0010817 obo:IAO_0000115 "A type of nevus sebaceous with a linear form, raised borders and yellowish color." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T12:17:17Z" ; oboInOwl:hasDbXref "MSH:D054000", "SNOMEDCT_US:239112008", "SNOMEDCT_US:52298009", "SNOMEDCT_US:707136009", "UMLS:C3854181" ; oboInOwl:id "HP:0010817" ; a owl:Class ; rdfs:label "Linear nevus sebaceous" ; rdfs:subClassOf obo:HP_0010815 . obo:HP_0010818 obo:IAO_0000115 "A generalized tonic seizure is a type of generalized motor seizure characterised by bilateral limb stiffening or elevation, often with neck stiffening without a subsequent clonic phase. The tonic activity can be a sustained abnormal posture, either in extension or flexion, sometimes accompanied by tremor of the extremities." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:03:51Z" ; oboInOwl:hasAlternativeId "HP:0002184" ; oboInOwl:hasDbXref "UMLS:C1836508" ; oboInOwl:hasExactSynonym "Generalised hypertonic seizure", "Generalised tonic seizure", "Generalised tonic seizures", "Generalized hypertonic seizure", "Generalized tonic seizures" ; oboInOwl:hasRelatedSynonym "Hypertonic seizures" ; oboInOwl:id "HP:0010818" ; a owl:Class ; rdfs:comment "Characterized by a sudden increase in muscle tone whereby the body, arms, or legs make sudden stiffening movements and consciousness is usually preserved. Tonic seizures can occur during sleep. Tonic seizures usually affect both sides of the body, and cause a fall if the affected person was standing when the seizure started." ; rdfs:label "Generalized tonic seizure" ; rdfs:subClassOf obo:HP_0032677, obo:HP_0032792 . obo:HP_0010819 obo:IAO_0000115 "Atonic seizure is a type of motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1 to 2 seconds, involving head, trunk, jaw, or limb musculature." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:13:06Z" ; oboInOwl:hasAlternativeId "HP:0002124" ; oboInOwl:hasDbXref "SNOMEDCT_US:189198006", "SNOMEDCT_US:42365007", "UMLS:C0270846", "UMLS:C1836509" ; oboInOwl:hasExactSynonym "Astatic seizure", "Astatic seizures", "Atonic seizures", "Drop attacks", "Drop seizures", "Hypotonic seizure" ; oboInOwl:hasRelatedSynonym "Hypotonic seizures", "Sudden loss of muscle tone" ; oboInOwl:id "HP:0010819" ; a owl:Class ; rdfs:comment "This term describes the initial semiology of the seizure without specifying whether the onset is focal or generalized. Thus it can be used for coding atonic seizures when the onset is not known." ; rdfs:label "Atonic seizure" ; rdfs:subClassOf obo:HP_0020219 . obo:HP_0010820 obo:IAO_0000115 "Focal emotional seizure with crying (dacrystic) is characterized by the presence of stereotyped crying, this may be accompanied by lacrimation, sad facial expression and sobbing. The subjective emotion of sadness may or may not be present." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:23:32Z" ; oboInOwl:hasDbXref "UMLS:C4023693" ; oboInOwl:hasExactSynonym "Dacrystic seizure", "Dacrystic seizures" ; oboInOwl:id "HP:0010820" ; a owl:Class ; rdfs:comment "Crying is a rare feature of an epileptic seizure, and is more commonly a feature of a non-epileptic seizure. The word dacrystic is derived from the Greek word dakryon (tear)." ; rdfs:label "Focal emotional seizure with crying" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0010821 obo:IAO_0000115 "Focal emotional seizure with laughing (gelastic) is characterized by bursts of laughter or giggling, usually without appropriate related emotion of happiness, and described as 'mirthless'." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:27:12Z" ; oboInOwl:hasDbXref "MSH:D004828", "SNOMEDCT_US:89525009", "UMLS:C0270820" ; oboInOwl:hasExactSynonym "Gelastic seizure", "Gelastic seizures" ; oboInOwl:id "HP:0010821" ; a owl:Class ; rdfs:comment "This seizure type is characteristic of seizures arising in the hypothalamus (see hypothalamic hamartoma), but can occur in seizures arising in the frontal or temporal lobes." ; rdfs:label "Focal emotional seizure with laughing" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0010822 obo:IAO_0000115 "A scintillating scotoma is a common visual aura that can preced a migraine, whereby a spot of flickering light near the center of the visual fields occurs. The spot prevents vision, and is thus termed scotoma. The scotoma can extend into one or more shimmering arcs of white or colored flashing lights." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:35:29Z" ; oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:2228002", "UMLS:C0235068" ; oboInOwl:id "HP:0010822" ; a owl:Class ; rdfs:label "Scintillating scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0010823 obo:IAO_0000115 "An overlap of the bony plates of the skull in an infant, with or without early closure." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:46:25Z" ; oboInOwl:hasDbXref "UMLS:C4023692" ; oboInOwl:hasExactSynonym "Cranial suture ridges" ; oboInOwl:id "HP:0010823" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Ridged cranial sutures" ; rdfs:subClassOf obo:HP_0011329 . obo:HP_0010824 obo:IAO_0000115 "Any structural abnormality of the fifth cranial nerve." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:51:21Z" ; oboInOwl:hasDbXref "UMLS:C4021226" ; oboInOwl:hasExactSynonym "Abnormal trigeminal nerve morphology", "Abnormality of the fifth cranial nerve", "Abnormality of the nervus trigeminus" ; oboInOwl:id "HP:0010824" ; a owl:Class ; rdfs:label "Abnormal fifth cranial nerve morphology" ; rdfs:subClassOf obo:HP_0001291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010825 obo:IAO_0000115 "Abnormality of the eleventh cranial nerve." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:54:53Z" ; oboInOwl:hasDbXref "UMLS:C4021225" ; oboInOwl:hasExactSynonym "Abnormality of cranial nerve XI", "Abnormality of the accessory nerve" ; oboInOwl:id "HP:0010825" ; a owl:Class ; rdfs:label "Abnormality of the eleventh cranial nerve" ; rdfs:subClassOf obo:HP_0001291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010826 obo:IAO_0000115 "Abnormality of the twelfth cranial nerve." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T03:58:00Z" ; oboInOwl:hasDbXref "UMLS:C4021224" ; oboInOwl:hasExactSynonym "Abnormality of cranial nerve 12", "Abnormality of cranial nerve xii", "Abnormality of the hypoglossal nerve" ; oboInOwl:id "HP:0010826" ; a owl:Class ; rdfs:label "Abnormality of the twelfth cranial nerve" ; rdfs:subClassOf obo:HP_3000075 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010827 obo:IAO_0000115 "Abnormality of the seventh cranial nerve sometimes also referred to as the facial nerve." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T04:04:55Z" ; oboInOwl:hasDbXref "UMLS:C4021223" ; oboInOwl:hasExactSynonym "Abnormality of the facial nerve" ; oboInOwl:id "HP:0010827" ; a owl:Class ; rdfs:label "Abnormality of the seventh cranial nerve" ; rdfs:subClassOf obo:HP_0001291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010828 obo:IAO_0000115 "Intermittent clonic or tonic contraction of muscles supplied by facial nerve. Muscles are relaxed in between contractions." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T04:15:33Z" ; oboInOwl:hasDbXref "MSH:D019569", "SNOMEDCT_US:13753008", "UMLS:C0278152" ; oboInOwl:hasExactSynonym "Spasms on one side of the face" ; oboInOwl:hasRelatedSynonym "Hemifacial spasms" ; oboInOwl:id "HP:0010828" ; a owl:Class ; rdfs:comment "Hemifacial spasm presents in the fifth or sixth decade of life, and is almost always unilateral. An attack usually begins with brief clonic movements of the orbicularis oculi and spreads over years to other facial muscles. Hemifacial spasm is often the result of chronic irritation of the facial nerve or nucleus." ; rdfs:label "Hemifacial spasm" ; rdfs:subClassOf obo:HP_0003739 . obo:HP_0010829 obo:IAO_0000115 "A reduced ability to discriminate between different temperatures." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:08:10Z" ; oboInOwl:hasAlternativeId "HP:0006901", "HP:0100772" ; oboInOwl:hasDbXref "UMLS:C4021222" ; oboInOwl:hasExactSynonym "Abnormality of temperature sensation", "Impaired temperature sensation", "Impaired thermal sensitivity", "Loss of temperature sensation" ; oboInOwl:id "HP:0010829" ; a owl:Class ; rdfs:comment "Temperature sensation can be tested by touching the skin several seconds with a water flask filled to the desired temperature. Persons with normal temperature sensation should at least be able to identify as warm a flask that is 35-36 degrees C and identify as cool a flask at 28-32 degrees C." ; rdfs:label "Impaired temperature sensation" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0010830 obo:IAO_0000115 "A reduced sense of touch (tactile sensation). This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:09:54Z" ; oboInOwl:hasDbXref "UMLS:C4021221" ; oboInOwl:hasExactSynonym "Abnormal thigmesthesia", "Impaired touch sensation", "Loss of tactile sensation" ; oboInOwl:id "HP:0010830" ; a owl:Class ; rdfs:label "Impaired tactile sensation" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0010831 obo:IAO_0000115 "A loss or impairment of the sensation of the relative position of parts of the body and joint position." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:12:53Z" ; oboInOwl:hasAlternativeId "HP:0010870" ; oboInOwl:hasDbXref "UMLS:C1856691" ; oboInOwl:hasExactSynonym "Abnormality of proprioception" ; oboInOwl:id "HP:0010831" ; a owl:Class ; rdfs:label "Impaired proprioception" ; rdfs:subClassOf obo:HP_0003474 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001507 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010832 obo:IAO_0000115 "Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:15:58Z" ; oboInOwl:hasDbXref "UMLS:C4023691" ; oboInOwl:id "HP:0010832" ; a owl:Class ; rdfs:label "Abnormality of pain sensation" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0010833 obo:IAO_0000115 "Spontaneous pain is a kind of neuropathic pain which occurs without an identifiable trigger." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:19:19Z" ; oboInOwl:hasDbXref "UMLS:C4023690" ; oboInOwl:id "HP:0010833" ; a owl:Class ; rdfs:label "Spontaneous pain sensation" ; rdfs:subClassOf obo:HP_0010832 . obo:HP_0010834 obo:IAO_0000115 "Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:23:26Z" ; oboInOwl:hasDbXref "UMLS:C4021220" ; oboInOwl:hasExactSynonym "Trophic changes" ; oboInOwl:id "HP:0010834" ; a owl:Class ; rdfs:label "Trophic changes related to pain" ; rdfs:subClassOf obo:HP_0010832 . obo:HP_0010835 obo:IAO_0000115 "A pattern of sensory loss with selective loss of touch sensation and proprioception without loss of pain and temperature, or vice-versa." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:28:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:87275002", "UMLS:C0278136" ; oboInOwl:id "HP:0010835" ; a owl:Class ; rdfs:comment "Dissociated sensory loss indicates a focal lesion within the spinal cord or brainstem." ; rdfs:label "Dissociated sensory loss" ; rdfs:subClassOf obo:HP_0003474 . obo:HP_0010836 obo:IAO_0000115 "An abnormal concentration of copper." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:39:09Z" ; oboInOwl:hasDbXref "UMLS:C4020766", "UMLS:C4023689" ; oboInOwl:hasRelatedSynonym "Abnormal copper levels" ; oboInOwl:id "HP:0010836" ; a owl:Class ; rdfs:comment "An abnormality in the concentration of copper, which normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins." ; rdfs:label "Abnormal circulating copper concentration" ; rdfs:subClassOf obo:HP_0011030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010837 obo:IAO_0000115 "Decreased concentration of ceruloplasmin in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:39:36Z" ; oboInOwl:hasDbXref "UMLS:C0240997" ; oboInOwl:hasExactSynonym "Decreased serum ceruloplasmin", "Decreased serum ceruloplasminA", "Hypoceruloplasminaemia", "Hypoceruloplasminemia" ; oboInOwl:id "HP:0010837" ; a owl:Class ; rdfs:comment "Ceruloplasmin is the major copper-carrying protein in the serum. Decreased serum ceruloplasmin levels can indicate other defects in copper metabolism." ; rdfs:label "Decreased circulating ceruloplasmin concentration" ; rdfs:subClassOf obo:HP_0033144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_P00450 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010838 obo:IAO_0000115 "An increased concentration of non ceruloplasmin bound copper in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:43:39Z" ; oboInOwl:hasDbXref "UMLS:C1848459" ; oboInOwl:id "HP:0010838" ; a owl:Class ; rdfs:label "High nonceruloplasmin-bound serum copper" ; rdfs:subClassOf obo:HP_0010836 . obo:HP_0010839 obo:IAO_0000115 "An increased concentration of copper in the urine." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T07:44:50Z" ; oboInOwl:hasDbXref "UMLS:C4023688" ; oboInOwl:hasExactSynonym "Increased urinary copper concentration" ; oboInOwl:id "HP:0010839" ; a owl:Class ; rdfs:label "Increased urinary copper concentration" ; rdfs:subClassOf obo:HP_0045036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010841 obo:IAO_0000115 "An abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG) and being identified at multiple locations (foci)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:01:28Z" ; oboInOwl:hasDbXref "UMLS:C4021219" ; oboInOwl:hasExactSynonym "Multifocal EEG abnormality" ; oboInOwl:id "HP:0010841" ; a owl:Class ; rdfs:label "Multifocal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0010843 obo:IAO_0000115 "Focal (localized) slow activity reflects focal dysfunction, not diffuse dysfunction (i.e., encephalopathy)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:10:59Z" ; oboInOwl:hasDbXref "UMLS:C4021218" ; oboInOwl:hasExactSynonym "EEG: focal slow activity", "EEG: localised slow activity", "EEG: localized slow activity" ; oboInOwl:id "HP:0010843" ; a owl:Class ; rdfs:label "EEG with focal slow activity" ; rdfs:subClassOf obo:HP_0011203 . obo:HP_0010844 obo:IAO_0000115 "Multifocal slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:13:54Z" ; oboInOwl:hasDbXref "UMLS:C4023687" ; oboInOwl:id "HP:0010844" ; a owl:Class ; rdfs:label "EEG with multifocal slow activity" ; rdfs:subClassOf obo:HP_0011203 . obo:HP_0010845 obo:IAO_0000115 "Diffuse slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:15:05Z" ; oboInOwl:hasDbXref "UMLS:C4021217" ; oboInOwl:hasExactSynonym "EEG with generalised slow activity", "EEG: generalised slow activity", "EEG: generalized slow activity" ; oboInOwl:id "HP:0010845" ; a owl:Class ; rdfs:comment "Generalized slow activity in the EEG typically signifies serious dysfunction of the entire brain." ; rdfs:label "EEG with generalized slow activity" ; rdfs:subClassOf obo:HP_0011203 . obo:HP_0010846 dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:18:01Z" ; oboInOwl:hasDbXref "UMLS:C4021216" ; oboInOwl:hasExactSynonym "EEG: persistent abnormal rhythmic activity" ; oboInOwl:id "HP:0010846" ; a owl:Class ; rdfs:label "EEG with persistent abnormal rhythmic activity" ; rdfs:subClassOf obo:HP_0011176 . obo:HP_0010847 obo:IAO_0000115 "The presence of complexes of slow spikes and slow waves (<2.5 Hz) in electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:18:25Z" ; oboInOwl:hasDbXref "UMLS:C4023686" ; oboInOwl:hasExactSynonym "Electroencephalogram demonstrated spike-slow wave discharges" ; oboInOwl:id "HP:0010847" ; a owl:Class ; rdfs:comment "Spikes (<70 ms) and sharp waves (70-200 ms) are sharp transient waves that have a strong association with epilepsy. No difference is noted in terms of clinical significance of spikes and sharp waves. Significant spikes usually are followed by a slow wave." ; rdfs:label "EEG with spike-wave complexes (<2.5 Hz)" ; rdfs:subClassOf obo:HP_0010850 . obo:HP_0010848 obo:IAO_0000115 "The presence of complexes of spikes and waves (2.5-3.5 Hz) in electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:21:13Z" ; oboInOwl:hasDbXref "UMLS:C4023685" ; oboInOwl:id "HP:0010848" ; a owl:Class ; rdfs:label "EEG with spike-wave complexes (2.5-3.5 Hz)" ; rdfs:subClassOf obo:HP_0010850 . obo:HP_0010849 obo:IAO_0000115 "The presence of complexes of spikes and waves (>3.5 Hz) in electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:22:40Z" ; oboInOwl:hasAlternativeId "HP:0007261" ; oboInOwl:hasDbXref "UMLS:C4020765", "UMLS:C4023684" ; oboInOwl:hasRelatedSynonym "EEG with 3-4-Hz spike waves" ; oboInOwl:id "HP:0010849" ; a owl:Class ; rdfs:label "EEG with spike-wave complexes (>3.5 Hz)" ; rdfs:subClassOf obo:HP_0010850 . obo:HP_0010850 obo:IAO_0000115 "Complexes of spikes (<70 ms) and sharp waves (70-200 ms), which are sharp transient waves that have a strong association with epilepsy, in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-10T08:23:28Z" ; oboInOwl:hasDbXref "UMLS:C4023683" ; oboInOwl:id "HP:0010850" ; a owl:Class ; rdfs:label "EEG with spike-wave complexes" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0010851 obo:IAO_0000115 "The burst suppression pattern in electroencephalography refers to a characteristic periodic pattern of low voltage (<10 microvolts) suppressed background and a relatively shorter pattern of higher amplitude slow, sharp, and spiking complexes." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:02:41Z" ; oboInOwl:hasDbXref "UMLS:C1969156" ; oboInOwl:id "HP:0010851" ; a owl:Class ; rdfs:comment "Burst suppression can occur in a generalized or lateralized distribution and is often a sign of severe encephalopathy. Generally, an interburst interval of 30 seconds or less is associated with a better prognosis than longer interburst intervals (>30 sec). Burst suppression is an electroencephalogram (EEG) pattern in which high voltage activity (burst) and flatline (suppression) periods alternate systematically but quasiperiodically (almost periodic but with variations in inter- and intra-burst duration) is a state of profound brain inactivation." ; rdfs:label "EEG with burst suppression" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0010852 obo:IAO_0000115 "EEG abnormalities (epileptiform discharges) evoked by flashing lights or black and white striped patterns." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:10:17Z" ; oboInOwl:hasAlternativeId "HP:0001330" ; oboInOwl:hasDbXref "UMLS:C3552821" ; oboInOwl:hasExactSynonym "Photoparoxysmal response on EEG" ; oboInOwl:id "HP:0010852" ; a owl:Class ; rdfs:comment "In some patients, seizures can be provoked by specific external factors (reflex epilepsy), including flickering lights and patterns. These patients commonly show epileptiform discharges in the EEG when stimulated with flashing lights, black and white striped patterns and television. These evoked EEG abnormalities are called photoparoxysmal responses." ; rdfs:label "EEG with photoparoxysmal response" ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0010853 obo:IAO_0000115 "Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:25:02Z" ; oboInOwl:hasDbXref "UMLS:C4021215" ; oboInOwl:hasExactSynonym "EEG: periodic lateralized epileptiform discharges" ; oboInOwl:id "HP:0010853" ; a owl:Class ; rdfs:comment "The epileptiform morphology of the discharges is not invariable, as PLEDS are often closer to slow waves than to sharp waves in morphology. PLEDs are often are caused by acute destructive focal lesions. PLEDs are often a transitory phenomenon, disappearing in a matter of weeks, even if the causal lesion persists, and often transforming into a less specific but more persistent focal slow appearance." ; rdfs:label "EEG with periodic lateralized epileptiform discharges" ; rdfs:subClassOf obo:HP_0011186 . obo:HP_0010854 obo:IAO_0000115 "An abnormal generalized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:34:13Z" ; oboInOwl:hasDbXref "UMLS:C4021214" ; oboInOwl:hasExactSynonym "EEG with generalised low amplitude activity", "EEG: generalised low amplitude activity" ; oboInOwl:id "HP:0010854" ; a owl:Class ; rdfs:label "EEG with generalized low amplitude activity" ; rdfs:subClassOf obo:HP_0011201 . obo:HP_0010855 obo:IAO_0000115 "An abnormal localized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:36:03Z" ; oboInOwl:hasDbXref "UMLS:C4021213" ; oboInOwl:hasExactSynonym "EEG with localised low amplitude activity", "EEG: localised low amplitude activity" ; oboInOwl:id "HP:0010855" ; a owl:Class ; rdfs:label "EEG with localized low amplitude activity" ; rdfs:subClassOf obo:HP_0011201 . obo:HP_0010856 obo:IAO_0000115 "Periodically occurring generalized periodic complexes." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:38:52Z" ; oboInOwl:hasDbXref "UMLS:C4021212" ; oboInOwl:hasExactSynonym "EEG: periodic complexes", "Radermecker complexes" ; oboInOwl:id "HP:0010856" ; a owl:Class ; rdfs:label "EEG with periodic complexes" ; rdfs:subClassOf obo:HP_0010857 . obo:HP_0010857 obo:IAO_0000115 "Periodically recurring abnormalities in the EEG." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:39:39Z" ; oboInOwl:hasDbXref "UMLS:C4021211" ; oboInOwl:hasExactSynonym "EEG: periodic abnormalities" ; oboInOwl:id "HP:0010857" ; a owl:Class ; rdfs:label "EEG with periodic abnormalities" ; rdfs:subClassOf obo:HP_0011200 . obo:HP_0010858 obo:IAO_0000115 "Epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2010-07-11T08:44:38Z" ; oboInOwl:hasDbXref "UMLS:C4023682" ; oboInOwl:id "HP:0010858" ; a owl:Class ; rdfs:comment "Hyperventilation (overbreathing) is widely used as a diagnostic procedure to activate epileptiform EEG discharges." ; rdfs:label "EEG with hyperventilation-induced epileptiform discharges" ; rdfs:subClassOf obo:HP_0011182 . obo:HP_0010859 obo:IAO_0000115 "A kind of breech presentation in which the hips are flexed and the knees are extended." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T12:33:15Z" ; oboInOwl:hasDbXref "MSH:D001946", "SNOMEDCT_US:18559007", "UMLS:C0233286" ; oboInOwl:id "HP:0010859" ; a owl:Class ; rdfs:label "Frank breech presentation" ; rdfs:subClassOf obo:HP_0001623 . obo:HP_0010860 obo:IAO_0000115 "A kind of breech presentation in which the hips are flexed and the knees are flexed." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T12:34:30Z" ; oboInOwl:hasDbXref "MSH:D001946", "SNOMEDCT_US:49168004", "UMLS:C0233283" ; oboInOwl:id "HP:0010860" ; a owl:Class ; rdfs:label "Complete breech presentation" ; rdfs:subClassOf obo:HP_0001623 . obo:HP_0010861 obo:IAO_0000115 "A kind of breech presentation in which one or both hips are extended and one or both of the fetus' feet are pointing down and entering the birth canal." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T12:34:57Z" ; oboInOwl:hasDbXref "MSH:D001946", "SNOMEDCT_US:38049006", "UMLS:C0426146" ; oboInOwl:id "HP:0010861" ; a owl:Class ; rdfs:label "Incomplete breech presentation" ; rdfs:subClassOf obo:HP_0001623 . obo:HP_0010862 obo:IAO_0000115 "A type of motor delay characterized by a delay in acquiring the ability to control the fingers and hands." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T05:44:08Z" ; oboInOwl:hasDbXref "UMLS:C4023681" ; oboInOwl:id "HP:0010862" ; a owl:Class ; rdfs:label "Delayed fine motor development" ; rdfs:subClassOf obo:HP_0001270 . obo:HP_0010863 obo:IAO_0000115 "A delay in the acquisition of the ability to understand the speech of others." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T06:02:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:229736005", "UMLS:C0454642" ; oboInOwl:id "HP:0010863" ; a owl:Class ; rdfs:label "Receptive language delay" ; rdfs:subClassOf obo:HP_0000750 . obo:HP_0010864 obo:IAO_0000115 "Severe mental retardation is defined as an intelligence quotient (IQ) in the range of 20-34." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T06:29:35Z" ; oboInOwl:hasAlternativeId "HP:0007196" ; oboInOwl:hasDbXref "SNOMEDCT_US:40700009", "UMLS:C0036857" ; oboInOwl:hasExactSynonym "Early and severe mental retardation", "Intellectual disability, severe", "Mental retardation, severe", "Severe mental retardation" ; oboInOwl:id "HP:0010864" ; a owl:Class ; rdfs:comment "Persons with severe mental retardation can be taught basic life skills and simple tasks with supervision." ; rdfs:label "Intellectual disability, severe" ; rdfs:subClassOf obo:HP_0001249 . obo:HP_0010865 obo:IAO_0000115 "An enduring pattern of uncooperative, defiant, and hostile behavior toward authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T07:09:09Z" ; oboInOwl:hasDbXref "MSH:D019958", "SNOMEDCT_US:18941000", "UMLS:C0029121" ; oboInOwl:id "HP:0010865" ; a owl:Class ; rdfs:comment "Oppositional defiant disorder is basically a persistent pattern of tantrums, arguing, and angry or disruptive behavior that goes beyond what can be considered normal." ; rdfs:label "Oppositional defiant disorder" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0010866 obo:IAO_0000115 "An incomplete closure of the abdominal wall." ; dcterms:creator ; oboInOwl:creation_date "2010-08-03T09:55:15Z" ; oboInOwl:hasDbXref "UMLS:C0238577" ; oboInOwl:hasExactSynonym "Abdominal wall defect", "Congenital anterior abdominal wall defect" ; oboInOwl:id "HP:0010866" ; a owl:Class ; rdfs:label "Abdominal wall defect" ; rdfs:subClassOf obo:HP_0004298 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010867 obo:IAO_0000115 "A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts." ; dcterms:creator ; oboInOwl:creation_date "2010-08-18T01:17:10Z" ; oboInOwl:hasDbXref "MSH:D001259", "SNOMEDCT_US:20262006", "SNOMEDCT_US:39384006", "UMLS:C0004134" ; oboInOwl:id "HP:0010867" ; a owl:Class ; rdfs:label "Dyssynergia" ; rdfs:subClassOf obo:HP_0001251 . obo:HP_0010868 obo:IAO_0000115 "A type of dyssynergia affecting eye movements and characterized by the inability to smoothly follow a visual target across the visual field." ; dcterms:creator ; oboInOwl:creation_date "2010-08-18T01:20:05Z" ; oboInOwl:hasDbXref "UMLS:C4023680" ; oboInOwl:id "HP:0010868" ; a owl:Class ; rdfs:label "Ocular dyssynergia" ; rdfs:subClassOf obo:HP_0010867 . obo:HP_0010869 obo:IAO_0000115 "A type of dyssynergy characterized by the lack of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed." ; dcterms:creator ; oboInOwl:creation_date "2010-08-18T01:39:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77743009", "UMLS:C0234355" ; oboInOwl:id "HP:0010869" ; a owl:Class ; rdfs:label "Asynergia" ; rdfs:subClassOf obo:HP_0010867 . obo:HP_0010871 obo:IAO_0000115 "Incoordination of movement caused by a deficit in the sensory nervous system. Sensory ataxia can be distinguished from cerebellar ataxia by asking the patient to close his or her eyes. Persons with cerebellar ataxia show only a minimal worsening of symptoms, whereas persons with sensory ataxia show a marked worsening of symptoms." ; dcterms:creator ; oboInOwl:creation_date "2010-08-18T01:57:54Z" ; oboInOwl:hasDbXref "MSH:D001259", "SNOMEDCT_US:445458007", "SNOMEDCT_US:69131009", "UMLS:C0037921", "UMLS:C0240991" ; oboInOwl:hasExactSynonym "Afferent ataxia", "Ataxia, sensory", "Spinal ataxia" ; oboInOwl:id "HP:0010871" ; a owl:Class ; rdfs:comment "Afferent (seonsory) ataxia is caused by lackof proprioceptive feedback during gait and stance. It can be caused by lesions to the peripheral nerves, the dorsal root ganglia, or the spinal cord. It can be distinguished from cerebellar ataxia by (1) heavy dependence of the affected individual on visual guidance; (2) a minor degree of oculomotor deficits; and (3) the absence of dysarthria. Afferent ataxia may be associated with impaired tendon reflexes and sensory deficits." ; rdfs:label "Sensory ataxia" ; rdfs:subClassOf obo:HP_0010831 . obo:HP_0010872 obo:IAO_0000115 "An inversion of the T-wave (which is normally positive)." ; dcterms:creator ; oboInOwl:creation_date "2010-08-25T03:29:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:59931005", "UMLS:C0520888" ; oboInOwl:hasExactSynonym "EKG: T-wave inversion" ; oboInOwl:id "HP:0010872" ; a owl:Class ; rdfs:label "T-wave inversion" ; rdfs:subClassOf obo:HP_0005135 . obo:HP_0010873 obo:IAO_0000115 "Atrophy of the cervical segment of the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2010-08-25T03:41:38Z" ; oboInOwl:hasDbXref "UMLS:C0742191" ; oboInOwl:id "HP:0010873" ; a owl:Class ; rdfs:label "Cervical spinal cord atrophy" ; rdfs:subClassOf obo:HP_0006827 . obo:HP_0010874 obo:IAO_0000115 "The presence of xanthomas (intra-and extra-cellular accumulations of cholesterol) extensor tendons (typically over knuckles, Achilles tendon, knee, and elbows)." ; dcterms:creator ; oboInOwl:creation_date "2010-08-30T11:01:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:69880002", "UMLS:C0221253" ; oboInOwl:hasExactSynonym "Tendon xanthomas" ; oboInOwl:id "HP:0010874" ; a owl:Class ; rdfs:label "Tendon xanthomatosis" ; rdfs:subClassOf obo:HP_0000991, obo:HP_0100261 . obo:HP_0010875 obo:IAO_0000115 "A diagnostic reflex elicited by stimulation of the skin over the surface of the lateral malleolus of the foot. The Chaddock refelx is present if there is extension of one or more or all of the toes with or without fanning of them when the external inframalleolar skin is stimulated. The Chaddock sign, similar to the Babinski sign, is taken to be an indication of disease of the spinocortical (pyramidal) tract." ; dcterms:creator ; oboInOwl:creation_date "2010-09-07T12:11:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:413813004", "UMLS:C1531651" ; oboInOwl:id "HP:0010875" ; a owl:Class ; rdfs:label "Chaddock reflex" ; rdfs:subClassOf obo:HP_0007256 . obo:HP_0010876 obo:IAO_0000115 "An abnormal level of a circulating protein in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-09-07T01:51:12Z" ; oboInOwl:hasDbXref "UMLS:C4020763", "UMLS:C4020764", "UMLS:C4023679" ; oboInOwl:hasExactSynonym "Abnormal circulating protein level", "Abnormality of circulating protein level" ; oboInOwl:hasRelatedSynonym "Blood protein disease", "Serum protein abnormality" ; oboInOwl:id "HP:0010876" ; a owl:Class ; rdfs:label "Abnormal circulating protein concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16541 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010877 obo:IAO_0000115 "A type of strabismus in which the fixating eye is always the same one, while the other eye is constantly deviated. Monocular strabismus is to be distinguished from alternating strabismus, in which either of the eyes 'squints' at different times." ; dcterms:creator ; oboInOwl:creation_date "2010-09-08T10:47:57Z" ; oboInOwl:hasDbXref "UMLS:C4023678" ; oboInOwl:hasExactSynonym "Unilateral strabismus" ; oboInOwl:id "HP:0010877" ; a owl:Class ; rdfs:label "Monocular strabismus" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0010878 obo:IAO_0000115 "The presence during the prenatal period of a cystic mass with multiple septa with multiple, asymmetric, thin-walled cysts near the posterior aspect of the neck. Fetal cystic hygroma can be defined as nuchal translucency with or without septations measuring greater than 3.0 mm. Increased NT refers to a measurement above the 95th centile, and the term is used irrespective of whether the collection of fluid is septated or not, and whether it is confined to the neck or envelopes the whole fetus. After 14 weeks, increased NT usually resolves, but in some cases it evolves into nuchal edema or cystic hygromas." ; dcterms:creator ; oboInOwl:creation_date "2010-09-13T08:02:26Z" ; oboInOwl:hasDbXref "MSH:C537852", "UMLS:C0948242" ; oboInOwl:hasExactSynonym "Foetal cystic hygroma" ; oboInOwl:id "HP:0010878" ; a owl:Class ; rdfs:comment "Upon ultrasound examination, fetal cystic hygroma presents as a cystic mass with multiple septa with multiple, asymmetric, thin-walled cysts related to the posterior aspect of the neck. Cystic hygromas can range from increased nuchal translucency to thin-walled cystic masses that may become larger than the fetal head. The cysts may result from a lymphatic abnormality, possibly one caused by absent or inefficient connections between the lymphatic and venous systems. Depending on the site, the cut off may vary from site to site. Lowest would be 2.5 mm and highest 3.5 mm." ; rdfs:label "Fetal cystic hygroma" ; rdfs:subClassOf obo:HP_0000476, obo:HP_0025667 . obo:HP_0010879 dcterms:creator ; oboInOwl:creation_date "2010-09-13T08:08:47Z" ; oboInOwl:hasDbXref "UMLS:C4023677" ; oboInOwl:id "HP:0010879" ; a owl:Class ; rdfs:label "Postnatal cystic hygroma" ; rdfs:subClassOf obo:HP_0000476 . obo:HP_0010880 obo:IAO_0000115 "Nuchal translucency is the sonographic appearance of subcutaneous accumulation of liquid in the back of the fetal neck in the first trimester of pregnancy (11-14 gestational weeks of pregnancy)." ; dcterms:creator ; oboInOwl:creation_date "2010-09-13T08:15:19Z" ; oboInOwl:hasDbXref "UMLS:C4023676" ; oboInOwl:id "HP:0010880" ; a owl:Class ; rdfs:comment "Increased nuchal translucency may be related to a cystic hygroma or to mesenchymal edema. Increased nuchal translucency can be classified into three categories: 1) cardiac abnormalities, combined with abnormal ductus venosus flow velocities, is found, leading to the theory that cardiac failure causes nuchal translucency enlargement; 2) various types of abnormalities are found in the extracellular matrix of the nuchal skin of fetuses with increased nuchal translucency; 3) abnormal lymphatic development is demonstrated in fetuses with increased nuchal translucency." ; rdfs:label "Increased nuchal translucency" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0025667 . obo:HP_0010881 obo:IAO_0000115 "An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta." ; dcterms:creator ; oboInOwl:creation_date "2010-09-13T08:24:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:90009001", "UMLS:C0266785" ; oboInOwl:hasExactSynonym "Umbilical cord issue" ; oboInOwl:id "HP:0010881" ; a owl:Class ; rdfs:label "Abnormality of the umbilical cord" ; rdfs:subClassOf obo:HP_0001194 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010882 obo:IAO_0000115 "A congenital disorder of the pulmonary valve in which the orifice of the valve fails to develop." ; dcterms:creator ; oboInOwl:creation_date "2010-09-20T11:08:09Z" ; oboInOwl:hasDbXref "Fyler:1001", "MSH:D018633", "SNOMEDCT_US:204342004", "SNOMEDCT_US:448564004", "UMLS:C0242855" ; oboInOwl:id "HP:0010882" ; a owl:Class ; rdfs:label "Pulmonary valve atresia" ; rdfs:subClassOf obo:HP_0001641 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002146 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010883 obo:IAO_0000115 "A congenital disorder of the aortic valve in which the orifice of the valve fails to develop." ; dcterms:creator ; oboInOwl:creation_date "2010-09-20T11:09:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:51442005", "UMLS:C0265843" ; oboInOwl:hasExactSynonym "Aortic atresia" ; oboInOwl:id "HP:0010883" ; a owl:Class ; rdfs:label "Aortic valve atresia" ; rdfs:subClassOf obo:HP_0001646 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010884 obo:IAO_0000115 "Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs." ; dcterms:creator ; oboInOwl:creation_date "2010-09-20T11:17:40Z" ; oboInOwl:hasDbXref "UMLS:C4023675" ; oboInOwl:id "HP:0010884" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Acromelia" ; rdfs:subClassOf obo:HP_0009815 . obo:HP_0010885 obo:IAO_0000115 "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." ; dcterms:creator ; oboInOwl:creation_date "2010-09-24T10:11:05Z" ; oboInOwl:hasDbXref "MSH:D010020", "SNOMEDCT_US:240196003", "SNOMEDCT_US:398199007", "SNOMEDCT_US:72756009", "UMLS:C0029445", "UMLS:C0085660", "UMLS:C0520474", "UMLS:C0877326" ; oboInOwl:hasExactSynonym "Aseptic bone necrosis", "Aseptic necrosis", "Bone infarction", "Death of bone due to decreased blood supply", "Ischaemic bone necrosis", "Ischemic bone necrosis", "Osteochondronecrosis", "Osteonecrosis" ; oboInOwl:id "HP:0010885" ; a owl:Class ; rdfs:comment "The interruption of the blood supply may have many different causes such as rapid growth, heredity causes, trauma or overuse, anatomic conformation, dietary imbalances or secondary effects of other diseases." ; rdfs:label "Avascular necrosis" ; rdfs:subClassOf obo:HP_0011843 . obo:HP_0010886 obo:IAO_0000115 "A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage." ; dcterms:creator ; oboInOwl:creation_date "2010-09-24T10:15:07Z" ; oboInOwl:hasDbXref "MSH:D010008", "SNOMEDCT_US:82562007", "UMLS:C0029421" ; oboInOwl:hasExactSynonym "Osteochondrosis dissecans" ; oboInOwl:id "HP:0010886" ; a owl:Class ; rdfs:comment "Joints that are most often affected by Osteochondrosis dissecans are elbow and hip, but also wrist and ankel joints." ; rdfs:label "Osteochondritis dissecans" ; rdfs:subClassOf obo:HP_0040188 . obo:HP_0010888 obo:IAO_0000115 "Morbus Koehler is a Juvenile aseptic necrosis affecting the Os naviculare pedis." ; dcterms:creator ; oboInOwl:creation_date "2010-09-25T11:04:19Z" ; oboInOwl:hasDbXref "UMLS:C4023674" ; oboInOwl:id "HP:0010888" ; a owl:Class ; rdfs:label "Morbus Koehler" ; rdfs:subClassOf obo:HP_0100323, obo:HP_0100339 . obo:HP_0010889 obo:IAO_0000115 "Morbus Kienboeck is a Juvenile aseptic necrosis affecting the Os lunatum." ; dcterms:creator ; oboInOwl:creation_date "2010-09-25T11:04:19Z" ; oboInOwl:hasDbXref "MSH:D010020", "SNOMEDCT_US:360466009", "SNOMEDCT_US:367356000", "SNOMEDCT_US:84062004", "UMLS:C0022682" ; oboInOwl:hasExactSynonym "Kienboeck's disease", "Kienböck's disease", "Lunatomalacia" ; oboInOwl:id "HP:0010889" ; a owl:Class ; rdfs:comment "Results most often from a stress-fracture and consecutive devascularisation of the Os lunatum." ; rdfs:label "Morbus Kienboeck" ; rdfs:subClassOf obo:HP_0004248, obo:HP_0100323 . obo:HP_0010890 obo:IAO_0000115 "Morbus Osgood-Schlatter is a Juvenile aseptic necrosis affecting the Tuberositas tibiae." ; dcterms:creator ; oboInOwl:creation_date "2010-09-25T11:04:19Z" ; oboInOwl:hasDbXref "MSH:D055034", "SNOMEDCT_US:72047008", "SNOMEDCT_US:79353000", "UMLS:C0029376" ; oboInOwl:hasExactSynonym "Osgood Schlatter disease" ; oboInOwl:id "HP:0010890" ; a owl:Class ; rdfs:comment "Painfull irritation and localized bony necrosis affecting the Tuberositas tibiae, where tha patellar tendon inserts." ; rdfs:label "Morbus Osgood-Schlatter" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0100323 . obo:HP_0010891 obo:IAO_0000115 "A developmental growth retardation of the vertebral end plates that may lead to secondary destruction of the vertebral end plates and protrusion of the nucleus pulposus into the vertebral body (so called Schmorl's nodes as seen on x-rays)." ; dcterms:creator ; oboInOwl:creation_date "2010-09-25T11:04:19Z" ; oboInOwl:hasDbXref "MSH:D012544", "SNOMEDCT_US:53406005", "UMLS:C0036310" ; oboInOwl:hasExactSynonym "Calve disease", "Juvenile osteochondrosis of the spine", "Scheuermann disease", "Scheuermann kyphosis", "Sherman's Disease" ; oboInOwl:id "HP:0010891" ; a owl:Class ; rdfs:comment "Scheuermann's disease usually manifests during the 2nd decade and leads to the appearance of the so called adolescence kyphosis. Late manifestations may be wedge-shaped vertebrae, platyspondyly and arthrosis affecting the verterbal collum." ; rdfs:label "Morbus Scheuermann" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0100323 . obo:HP_0010892 obo:IAO_0000115 "Any deviation from the normal concentration of a branched chain family amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-11-11T02:53:04Z" ; oboInOwl:hasDbXref "UMLS:C4023673" ; oboInOwl:id "HP:0010892" ; a owl:Class ; rdfs:label "Abnormal circulating branched chain amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009081 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010893 obo:IAO_0000115 "Any deviation from the normal concentration of phenylalanine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:23:30Z" ; oboInOwl:hasDbXref "UMLS:C4023672" ; oboInOwl:hasExactSynonym "Abnormality of phenylalanine metabolism" ; oboInOwl:id "HP:0010893" ; a owl:Class ; rdfs:label "Abnormal circulating phenylalanine concentration" ; rdfs:subClassOf obo:HP_0004338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006558 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010894 obo:IAO_0000115 "Any deviation from the normal concentration of a serine family amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-11-30T05:21:41Z" ; oboInOwl:hasDbXref "UMLS:C4023671" ; oboInOwl:hasExactSynonym "Abnormality of serine family amino acid metabolism" ; oboInOwl:id "HP:0010894" ; a owl:Class ; rdfs:label "Abnormal circulating serine family amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009069 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010895 obo:IAO_0000115 "Any deviation from the normal concentration of glycine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-11-30T05:27:24Z" ; oboInOwl:hasDbXref "UMLS:C4023670" ; oboInOwl:id "HP:0010895" ; a owl:Class ; rdfs:label "Abnormal circulating glycine concentration" ; rdfs:subClassOf obo:HP_0010894 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010896 obo:IAO_0000115 "An elevated plasma concentration of sarcosine." ; dcterms:creator ; oboInOwl:creation_date "2010-11-30T05:38:24Z" ; oboInOwl:hasDbXref "MSH:C537236", "SNOMEDCT_US:64852002", "UMLS:C0268563" ; oboInOwl:hasExactSynonym "High plasma sarcosine levels" ; oboInOwl:id "HP:0010896" ; a owl:Class ; rdfs:comment "Sarcosine is the N-methyl derivative of glycine." ; rdfs:label "Hypersarcosinemia" ; rdfs:subClassOf obo:HP_0010898 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15611 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010897 obo:IAO_0000115 "An elevated urinary concentration of sarcosine." ; dcterms:creator ; oboInOwl:creation_date "2010-11-30T05:43:45Z" ; oboInOwl:hasDbXref "UMLS:C4023669" ; oboInOwl:hasExactSynonym "High urine sarcosine levels" ; oboInOwl:id "HP:0010897" ; a owl:Class ; rdfs:label "Hypersarcosinuria" ; rdfs:subClassOf obo:HP_0033100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001088 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CHEBI_15611 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010898 obo:IAO_0000115 "An deviation from the normal concentration of sarcosine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-11-30T05:44:10Z" ; oboInOwl:hasDbXref "UMLS:C4023668" ; oboInOwl:id "HP:0010898" ; a owl:Class ; rdfs:comment "Sarcosine, which is also known as N-methylglycine, is an intermediate and byproduct in glycine synthesis and degradation." ; rdfs:label "Abnormal circulating sarcosine concentration" ; rdfs:subClassOf obo:HP_0010894 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_1901052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010899 obo:IAO_0000115 "Any deviation from the normal concentration of an aspartate family amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-02T04:40:57Z" ; oboInOwl:hasDbXref "UMLS:C4023667" ; oboInOwl:id "HP:0010899" ; a owl:Class ; rdfs:label "Abnormal circulating aspartate family amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010900 obo:IAO_0000115 "Any deviation from the normal concentration of threonine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-02T04:42:19Z" ; oboInOwl:hasDbXref "UMLS:C4023666" ; oboInOwl:hasExactSynonym "Abnormality of threonine metabolism" ; oboInOwl:id "HP:0010900" ; a owl:Class ; rdfs:label "Abnormal circulating threonine concentration" ; rdfs:subClassOf obo:HP_0010899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006566 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010901 obo:IAO_0000115 "Any deviation from the normal concentration of methionine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-02T05:15:22Z" ; oboInOwl:hasDbXref "UMLS:C4023665" ; oboInOwl:hasExactSynonym "Abnormality of methionine metabolism" ; oboInOwl:id "HP:0010901" ; a owl:Class ; rdfs:label "Abnormal circulating methionine concentration" ; rdfs:subClassOf obo:HP_0004339, obo:HP_0010899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006555 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010902 obo:IAO_0000115 "Any deviation from the normal concentration of a glutamine family amino acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-03T04:30:22Z" ; oboInOwl:hasDbXref "UMLS:C4023664" ; oboInOwl:id "HP:0010902" ; a owl:Class ; rdfs:label "Abnormal circulating glutamine family amino acid concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010903 obo:IAO_0000115 "Any deviation from the normal concentration of glutamine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-03T04:31:22Z" ; oboInOwl:hasDbXref "UMLS:C4023663" ; oboInOwl:id "HP:0010903" ; a owl:Class ; rdfs:comment "Glutamine is a charge-neutral, polar amino acid." ; rdfs:label "Abnormal circulating glutamine concentration" ; rdfs:subClassOf obo:HP_0010902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006541 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010904 obo:IAO_0000115 "An abnormality of a histidine metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T07:13:56Z" ; oboInOwl:hasDbXref "UMLS:C4023662" ; oboInOwl:hasExactSynonym "Abnormality of histidine metabolism" ; oboInOwl:id "HP:0010904" ; a owl:Class ; rdfs:label "Abnormal circulating histidine concentration" ; rdfs:subClassOf obo:HP_0033107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006547 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010905 obo:IAO_0100001 "HP:0010904" ; oboInOwl:id "HP:0010905" ; a owl:Class ; rdfs:label "obsolete Abnormality of histidine metabolism" ; owl:deprecated true . obo:HP_0010906 obo:IAO_0000115 "An increased concentration of histidine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T07:27:47Z" ; oboInOwl:hasDbXref "MSH:C538320", "SNOMEDCT_US:124628005", "SNOMEDCT_US:410058007", "UMLS:C0220992" ; oboInOwl:hasExactSynonym "High blood histidine level", "Histidinemia" ; oboInOwl:id "HP:0010906" ; a owl:Class ; rdfs:comment "Blood histidine levels over 500 micromole per liter. Normal blood histidine levels are around 80-90 micromole per liter." ; rdfs:label "Hyperhistidinemia" ; rdfs:subClassOf obo:HP_0010904 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010907 obo:IAO_0000115 "Any deviation from the normal concentration of proline or a proline metabolite in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T07:50:08Z" ; oboInOwl:hasDbXref "UMLS:C4023661" ; oboInOwl:id "HP:0010907" ; a owl:Class ; rdfs:label "Abnormal circulating proline concentration" ; rdfs:subClassOf obo:HP_0010902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006560 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010908 obo:IAO_0000115 "Any deviation from the normal concentration of lysine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:05:55Z" ; oboInOwl:hasDbXref "UMLS:C4023660" ; oboInOwl:hasExactSynonym "Abnormality of lysine metabolism" ; oboInOwl:id "HP:0010908" ; a owl:Class ; rdfs:label "Abnormal circulating lysine concentration" ; rdfs:subClassOf obo:HP_0010899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006553 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010909 obo:IAO_0000115 "Any deviation from the normal concentration of arginine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:25:05Z" ; oboInOwl:hasDbXref "UMLS:C4023659" ; oboInOwl:hasExactSynonym "Abnormality of arginine metabolism" ; oboInOwl:id "HP:0010909" ; a owl:Class ; rdfs:comment "Arginine is a charged, aliphatic amino acid." ; rdfs:label "Abnormal circulating arginine concentration" ; rdfs:subClassOf obo:HP_0010902 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006525 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010910 obo:IAO_0000115 "An increased concentration of valine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:44:27Z" ; oboInOwl:hasDbXref "MSH:C536524", "SNOMEDCT_US:47719001", "UMLS:C0268573" ; oboInOwl:hasExactSynonym "High blood valine concentration" ; oboInOwl:id "HP:0010910" ; a owl:Class ; rdfs:label "Hypervalinemia" ; rdfs:subClassOf obo:HP_0010914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27266 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010911 obo:IAO_0000115 "An increased concentration of leucine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:45:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:24013007", "UMLS:C0268576" ; oboInOwl:hasExactSynonym "High blood leucine concentration" ; oboInOwl:id "HP:0010911" ; a owl:Class ; rdfs:comment "Normal leucine blood levels are around 120-160 micromole per liter." ; rdfs:label "Hyperleucinemia" ; rdfs:subClassOf obo:HP_0004357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010912 obo:IAO_0000115 "Any deviation from the normal concentration of isoleucine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:47:47Z" ; oboInOwl:hasDbXref "UMLS:C4023658" ; oboInOwl:id "HP:0010912" ; a owl:Class ; rdfs:label "Abnormal circulating isoleucine concentration" ; rdfs:subClassOf obo:HP_0010892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006549 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010913 obo:IAO_0000115 "An increased concentration of isoleucine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:49:42Z" ; oboInOwl:hasDbXref "UMLS:C4023657" ; oboInOwl:hasExactSynonym "High blood isoleucine concentration" ; oboInOwl:id "HP:0010913" ; a owl:Class ; rdfs:comment "Normal isoleucine blood levels are around 60-80 micromole per liter." ; rdfs:label "Hyperisoleucinemia" ; rdfs:subClassOf obo:HP_0010912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010914 obo:IAO_0000115 "Any deviation from the normal circulation of valine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:51:14Z" ; oboInOwl:hasDbXref "UMLS:C4023656" ; oboInOwl:hasExactSynonym "Abnormality of valine metabolism" ; oboInOwl:id "HP:0010914" ; a owl:Class ; rdfs:label "Abnormal circulating valine concentration" ; rdfs:subClassOf obo:HP_0010892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010915 obo:IAO_0000115 "An abnormality of a pyruvate family amino acid metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:55:53Z" ; oboInOwl:hasDbXref "UMLS:C4023655" ; oboInOwl:hasExactSynonym "Abnormality of pyruvate family amino acid metabolism" ; oboInOwl:id "HP:0010915" ; a owl:Class ; rdfs:label "Abnormal circulating pyruvate family amino acid concentration" ; rdfs:subClassOf obo:HP_0033108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010916 obo:IAO_0000115 "An abnormality of an alanine metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T08:57:53Z" ; oboInOwl:hasDbXref "UMLS:C4023654" ; oboInOwl:hasExactSynonym "Abnormality of alanine metabolism" ; oboInOwl:id "HP:0010916" ; a owl:Class ; rdfs:label "Abnormal circulating alanine concentration" ; rdfs:subClassOf obo:HP_0010915 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010917 obo:IAO_0000115 "Any deviation from the normal concentration of tyrosine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-08T09:13:53Z" ; oboInOwl:hasDbXref "UMLS:C4023653" ; oboInOwl:id "HP:0010917" ; a owl:Class ; rdfs:label "Abnormal circulating tyrosine concentration" ; rdfs:subClassOf obo:HP_0004338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006570 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010918 obo:IAO_0000115 "An abnormality of a cysteine metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2010-12-11T11:45:39Z" ; oboInOwl:hasDbXref "UMLS:C4023652" ; oboInOwl:id "HP:0010918" ; a owl:Class ; rdfs:label "Abnormal circulating cysteine concentration" ; rdfs:subClassOf obo:HP_0004339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006534 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010919 obo:IAO_0000115 "An abnormality of a homocysteine metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2010-12-11T11:48:52Z" ; oboInOwl:hasDbXref "UMLS:C4023651" ; oboInOwl:id "HP:0010919" ; a owl:Class ; rdfs:label "Abnormal circulating homocysteine concentration" ; rdfs:subClassOf obo:HP_0004339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050667 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010920 obo:IAO_0000115 "Zonular cataracts are defined to be cataracts that affect specific regions of the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-12-12T12:00:37Z" ; oboInOwl:hasAlternativeId "HP:0007713" ; oboInOwl:hasDbXref "MSH:C535342", "UMLS:C1861821" ; oboInOwl:id "HP:0010920" ; a owl:Class ; rdfs:comment "Zonular cataracts include specific regions of the lens and include nuclear cataracts, which affect the fetal or embryonic lens nucleus and lamellar cataracts. These tend to affect lens fibers that are formed at the same time, resulting in a shell like opacity. Zonular cataracts can also be characterized as dense or pulverulent (dusty appearing), and can be accompanied by arcuate opacities extending into the lens cortex, called cortical riders." ; rdfs:label "Zonular cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0010921 obo:IAO_0000115 "A 'coral-like' pattern of opacity in the lens of the eye. That is, a cataract with an irregular, stellate form." ; dcterms:creator ; oboInOwl:creation_date "2010-12-12T12:16:28Z" ; oboInOwl:hasDbXref "UMLS:C1392104" ; oboInOwl:id "HP:0010921" ; a owl:Class ; rdfs:label "Coralliform cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0010922 obo:IAO_0000115 "A form of cataract in which the lens substance has shrunk, leaving a collapsed, flattened capsule with little or no cortex or epithelium on the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-12-12T12:31:45Z" ; oboInOwl:hasDbXref "MSH:D002386", "UMLS:C0524524" ; oboInOwl:id "HP:0010922" ; a owl:Class ; rdfs:label "Membranous cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0010923 obo:IAO_0000115 "A type of cataract affecting the anterior pole of lens immediately adjacent to ('beneath') the lens capsule." ; dcterms:creator ; oboInOwl:creation_date "2010-12-12T12:51:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:315352000", "UMLS:C1112768" ; oboInOwl:id "HP:0010923" ; a owl:Class ; rdfs:label "Anterior subcapsular cataract" ; rdfs:subClassOf obo:HP_0000523 . obo:HP_0010924 obo:IAO_0000115 "A cataract that affects the posterior part of the cortex of the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-12-12T12:55:36Z" ; oboInOwl:hasDbXref "UMLS:C4023650" ; oboInOwl:id "HP:0010924" ; a owl:Class ; rdfs:label "Posterior cortical cataract" ; rdfs:subClassOf obo:HP_0100019 . obo:HP_0010925 dcterms:creator ; oboInOwl:creation_date "2010-12-12T04:26:25Z" ; oboInOwl:hasDbXref "UMLS:C4023649" ; oboInOwl:id "HP:0010925" ; a owl:Class ; rdfs:label "Nuclear punctate cataract" ; rdfs:subClassOf obo:HP_0007648, obo:HP_0100018 . obo:HP_0010926 obo:IAO_0000115 "A kind of nuclear cataract characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-12-19T03:47:35Z" ; oboInOwl:hasDbXref "MSH:C566162", "UMLS:C1861832" ; oboInOwl:hasExactSynonym "Fasciculiform cataract", "Frosted cataract", "Needle-shaped cataract" ; oboInOwl:id "HP:0010926" ; a owl:Class ; rdfs:comment "This phenotype is characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens. Some crystals may be 11 mm in length, and their biochemical composition is not known. This type of cataract is considered to be different from the corraliform cataract, which does not show the needlelike projections. This opacity does not appear to respect the sutures or the direction of the lens fibers (Francois 1963) and appears to originate from the fetal and postnatal nuclei, suggesting a congenital origin with some postnatal progression, if any. See Figure 1 of PMID:10521291." ; rdfs:label "Aculeiform cataract" ; rdfs:subClassOf obo:HP_0100018 . obo:HP_0010927 obo:IAO_0000115 "An abnormality of divalent inorganic cation homeostasis." ; dcterms:creator ; oboInOwl:creation_date "2011-01-06T07:47:18Z" ; oboInOwl:hasDbXref "UMLS:C4023648" ; oboInOwl:hasExactSynonym "Abnormality of divalent inorganic cation homeostasis" ; oboInOwl:id "HP:0010927" ; a owl:Class ; rdfs:label "Abnormal blood inorganic cation concentration" ; rdfs:subClassOf obo:HP_0010929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0072507 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010928 obo:IAO_0100001 "HP:0003218" ; oboInOwl:id "HP:0010928" ; a owl:Class ; rdfs:label "obsolete Increased urinary orotic acid concentration" ; owl:deprecated true . obo:HP_0010929 obo:IAO_0000115 "An abnormality of cation homeostasis." ; dcterms:creator ; oboInOwl:creation_date "2011-01-06T10:36:04Z" ; oboInOwl:hasDbXref "UMLS:C4023646" ; oboInOwl:hasExactSynonym "Abnormality of cation homeostasis" ; oboInOwl:id "HP:0010929" ; a owl:Class ; rdfs:label "Abnormal blood cation concentration" ; rdfs:subClassOf obo:HP_0003111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055080 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010930 obo:IAO_0000115 "An abnormality of monovalent inorganic cation homeostasis." ; dcterms:creator ; oboInOwl:creation_date "2011-01-06T10:38:38Z" ; oboInOwl:hasDbXref "UMLS:C4023645" ; oboInOwl:hasExactSynonym "Abnormality of monovalent inorganic cation homeostasis" ; oboInOwl:id "HP:0010930" ; a owl:Class ; rdfs:label "Abnormal blood monovalent inorganic cation concentration" ; rdfs:subClassOf obo:HP_0010929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055067 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010931 obo:IAO_0000115 "An abnormal concentration of sodium." ; dcterms:creator ; oboInOwl:creation_date "2011-01-06T10:40:20Z" ; oboInOwl:hasDbXref "UMLS:C4023644" ; oboInOwl:hasExactSynonym "Abnormal blood Na+ levels", "Abnormal circulating Na concentration", "Abnormality of sodium homeostasis" ; oboInOwl:id "HP:0010931" ; a owl:Class ; rdfs:label "Abnormal blood sodium concentration" ; rdfs:subClassOf obo:HP_0010930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010932 obo:IAO_0000115 "An abnormality of a nucleobase metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2011-01-06T10:46:17Z" ; oboInOwl:hasDbXref "UMLS:C4020762", "UMLS:C4023643" ; oboInOwl:hasRelatedSynonym "Abnormal nucleoside levels" ; oboInOwl:id "HP:0010932" ; a owl:Class ; rdfs:comment "This term is used to refers to abnormality in chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." ; rdfs:label "Abnormal circulating nucleobase concentration" ; rdfs:subClassOf obo:HP_0001939, obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009112 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010933 obo:IAO_0000115 "An increased level of xanthine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-10T07:53:26Z" ; oboInOwl:hasDbXref "UMLS:C4023642" ; oboInOwl:hasExactSynonym "Increased circulating xanthine concentration" ; oboInOwl:id "HP:0010933" ; a owl:Class ; rdfs:comment "Xanthine is a purine base that is a product of purine degradation." ; rdfs:label "Hyperxanthinemia" ; rdfs:subClassOf obo:HP_0004368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010934 obo:IAO_0000115 "An increased concentration of xanthine in the urine." ; dcterms:creator ; oboInOwl:creation_date "2011-01-10T07:55:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:190919008", "SNOMEDCT_US:54627004", "UMLS:C0220988" ; oboInOwl:hasExactSynonym "Increased urinary xanthine" ; oboInOwl:id "HP:0010934" ; a owl:Class ; rdfs:comment "Xanthinuria is generally caused by a defect in the xanthine oxidase, an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. The formation of xanthine stones in the urinary tract is the main evidence of this abnormality." ; rdfs:label "Xanthinuria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15318 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010935 obo:IAO_0000115 "An abnormality of the upper urinary tract." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T11:37:29Z" ; oboInOwl:hasDbXref "UMLS:C4023641" ; oboInOwl:hasExactSynonym "Abnormality of the upper urinary tract" ; oboInOwl:id "HP:0010935" ; a owl:Class ; rdfs:comment "The upper urinary tract is a subdivision of urinary system which consists of the kidney and the ureters." ; rdfs:label "Abnormality of the upper urinary tract" ; rdfs:subClassOf obo:HP_0000079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010936 obo:IAO_0000115 "An abnormality of the lower urinary tract." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T11:39:17Z" ; oboInOwl:hasDbXref "UMLS:C4023640" ; oboInOwl:id "HP:0010936" ; a owl:Class ; rdfs:comment "The lower urinary tract is a subdivision of urinary system which consists of the urinary bladder and the urethra." ; rdfs:label "Abnormality of the lower urinary tract" ; rdfs:subClassOf obo:HP_0000079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001556 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010937 obo:IAO_0000115 "An abnormality of the nasal skeleton." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:19:38Z" ; oboInOwl:hasDbXref "UMLS:C4023639", "UMLS:C4280361" ; oboInOwl:hasExactSynonym "Abnormality of the nasal skeleton", "Anomaly of the nasal skeleton" ; oboInOwl:hasNarrowSynonym "Deformity of the bones of the nose", "Deformity of the nasal skeleton", "Distortion of the bones of the nose", "Distortion of the nasal skeleton", "Malformation of the bones of the nose", "Malformation of the nasal skeleton" ; oboInOwl:id "HP:0010937" ; a owl:Class ; rdfs:label "Abnormal nasal skeleton morphology" ; rdfs:subClassOf obo:HP_0005105, obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010938 obo:IAO_0000115 "An abnormality of the external nose." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:21:10Z" ; oboInOwl:hasDbXref "UMLS:C2164724", "UMLS:C4023638", "UMLS:C4280360" ; oboInOwl:hasExactSynonym "Abnormality of the external nose", "Anomaly of the external nose" ; oboInOwl:hasNarrowSynonym "Deformity of the external nose", "Malformation of the external nose" ; oboInOwl:id "HP:0010938" ; a owl:Class ; rdfs:label "Abnormal external nose morphology" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007827 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010939 obo:IAO_0000115 "An abnormality of the nasal bone, comprising the left nasal bone and the right nasal bone." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:28:45Z" ; oboInOwl:hasDbXref "UMLS:C4023637" ; oboInOwl:hasExactSynonym "Abnormality of the nasal bone", "Anomaly of the nasal bones" ; oboInOwl:hasNarrowSynonym "Deformity of the nasal bones", "Malformation of the nasal bones" ; oboInOwl:id "HP:0010939" ; a owl:Class ; rdfs:label "Abnormal nasal bone morphology" ; rdfs:subClassOf obo:HP_0010937 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010940 obo:IAO_0000115 "Absence or underdevelopment of the nasal bone." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:31:16Z" ; oboInOwl:hasDbXref "UMLS:C4023636" ; oboInOwl:id "HP:0010940" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the nasal bone" ; rdfs:subClassOf obo:HP_0010939 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010941 obo:IAO_0000115 "Absence of the nasal bone." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:32:39Z" ; oboInOwl:hasDbXref "MSH:C562753", "SNOMEDCT_US:91900007", "UMLS:C0339850", "UMLS:C0339851", "UMLS:C4023635" ; oboInOwl:hasExactSynonym "Failure of development of the nasal bone", "Lack of development of the nasal bone" ; oboInOwl:hasNarrowSynonym "Absence of the nasal bone", "Agenesis of the nasal bone", "Missing nasal bone" ; oboInOwl:id "HP:0010941" ; a owl:Class ; rdfs:label "Aplasia of the nasal bone" ; rdfs:subClassOf obo:HP_0010940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010942 obo:IAO_0000115 "A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T02:52:26Z" ; oboInOwl:hasDbXref "UMLS:C4023634" ; oboInOwl:id "HP:0010942" ; a owl:Class ; rdfs:comment "An echogenic intracardiac focus (EIF) is generally believed to be a normal variant, observed in 5% of all fetuses during second trimester sonography, but the risk of aneuploidies such as Down syndrome is increased in fetuses with EIF." ; rdfs:label "Echogenic intracardiac focus" ; rdfs:subClassOf obo:HP_0010948, obo:HP_0011425 . obo:HP_0010943 obo:IAO_0000115 "Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:04:36Z" ; oboInOwl:hasDbXref "MSH:D058535", "UMLS:C2936423" ; oboInOwl:hasExactSynonym "Echogenic bowel", "Echogenic foetal bowel", "Hyperechogenic fetal bowel", "Prenatal ultrasound: hyperechogenic bowel" ; oboInOwl:id "HP:0010943" ; a owl:Class ; rdfs:comment "Echogenic fetal bowel may be observed in fetuses with normal outcomes, but may also be a marker for diseases such as cystic fibrosis, congenital infection, chromosomal anomalies, and intraamniotic bleeding. This finding can be observed on prenatal ultrasound. The echogenicity has been classified as either focal or multifocal. Grade 2 suggests that echogenicity is equal to bone whereas grade 3 suggests that it is greater." ; rdfs:label "Echogenic fetal bowel" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0034207 . obo:HP_0010944 obo:IAO_0000115 "An abnormality of the renal pelvis." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:33:55Z" ; oboInOwl:hasDbXref "UMLS:C4023633" ; oboInOwl:hasExactSynonym "Abnormality of the renal pelvis" ; oboInOwl:id "HP:0010944" ; a owl:Class ; rdfs:label "Abnormal renal pelvis morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010945 obo:IAO_0000115 "Mild pyelectasis is defined as a hypoechoic spherical or elliptical space within the renal pelvis that measures at least 5mm and not more than 10 mm. The measurement is taken on a transverse section through the fetal renal pelvis using the maximum anterior-to-posterior measurement." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:36:31Z" ; oboInOwl:hasDbXref "MSH:D058536", "SNOMEDCT_US:430035004", "UMLS:C2317073" ; oboInOwl:hasExactSynonym "Fetal renal pelvic dilatation", "Foetal pyelectasis", "Foetal renal pelvic dilatation", "Mild fetal hydronephrosis", "Mild foetal hydronephrosis" ; oboInOwl:id "HP:0010945" ; a owl:Class ; rdfs:comment "The renal pelvis is the part of the kidney that collects urine. Fetal pyelectasis is a prenatal ultrasound finding that is diagnosed with enlargement of the renal pelvis from 4 to 10 millimeters. In many cases, fetal pyelectasis resolves spontaneously. Note that dilatation of the renal pelvis to more than 10 mm is referred to as severe pyelectasis or hydronephrosis. Measurements less than 5mm are normal, should not be designated as pyelectasis, and should not be reported (PMID:16100637)." ; rdfs:label "Fetal pyelectasis" ; rdfs:subClassOf obo:HP_0010944, obo:HP_0011425, obo:HP_0034242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010946 obo:IAO_0000115 "The presence of dilatation of the renal pelvis." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:39:20Z" ; oboInOwl:hasDbXref "UMLS:C1868864" ; oboInOwl:id "HP:0010946" ; a owl:Class ; rdfs:label "Dilatation of the renal pelvis" ; rdfs:subClassOf obo:HP_0010944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010947 obo:IAO_0000115 "A first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:50:45Z" ; oboInOwl:hasDbXref "UMLS:C4023632" ; oboInOwl:id "HP:0010947" ; a owl:Class ; rdfs:comment "The ductus venosus is a bypass between the umbilical vein and the inferior vena cava in the fetus. The blood flow through this bypass decreases immediately after birth. Functional closure, which is followed by anatomic closure, is virtually complete within a few weeks of birth. The typical abnormal finding in abnormal ductus venosus flow is a reversed a-wave." ; rdfs:label "Abnormality of ductus venosus blood flow" ; rdfs:subClassOf obo:HP_0034190 . obo:HP_0010948 obo:IAO_0000115 "A structural abnormality of the fetal circulation system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T03:53:44Z" ; oboInOwl:hasDbXref "UMLS:C4021210" ; oboInOwl:hasExactSynonym "Abnormality of the fetal cardiovascular system", "Abnormality of the fetal circulation system", "Abnormality of the foetal cardiovascular system", "Abnormality of the foetal circulation system" ; oboInOwl:id "HP:0010948" ; a owl:Class ; rdfs:label "Abnormal fetal cardiovascular morphology" ; rdfs:subClassOf obo:HP_0030680, obo:HP_0034058 . obo:HP_0010949 obo:IAO_0000115 "A first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein." ; dcterms:creator ; oboInOwl:creation_date "2011-01-16T04:15:43Z" ; oboInOwl:hasDbXref "UMLS:C4023631" ; oboInOwl:id "HP:0010949" ; a owl:Class ; rdfs:comment "Umbilical vein blood flow (UVBF) is closely related to the mass of placental cotyledons and is considered an expression of the amount of oxygen and nutrients transferred from the mother to the fetus." ; rdfs:label "Abnormality of umbilical vein blood flow" ; rdfs:subClassOf obo:HP_0025657 . obo:HP_0010950 obo:IAO_0000115 "An abnormality of the fourth ventricle." ; dcterms:creator ; oboInOwl:creation_date "2011-01-17T12:58:00Z" ; oboInOwl:hasDbXref "UMLS:C4023630" ; oboInOwl:hasExactSynonym "Abnormality of the fourth ventricle" ; oboInOwl:id "HP:0010950" ; a owl:Class ; rdfs:comment "The fourth ventricle is the cerebral ventricle that extends from the cerebral aqueduct to the obex, and is located within the pons and the upper part of the medulla oblongata." ; rdfs:label "Abnormal fourth ventricle morphology" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010951 obo:IAO_0000115 "An abnormality of the third ventricle." ; dcterms:creator ; oboInOwl:creation_date "2011-01-17T01:00:31Z" ; oboInOwl:hasDbXref "UMLS:C4023629" ; oboInOwl:hasExactSynonym "Abnormality of the third ventricle" ; oboInOwl:id "HP:0010951" ; a owl:Class ; rdfs:comment "The third ventricle is the cerebral ventricle that is located in the midline between the left and right lateral ventricles." ; rdfs:label "Abnormal third ventricle morphology" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002286 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010952 obo:IAO_0000115 "A kind of ventriculomegaly occurring in the fetal period and usually diagnosed by prenatal ultrasound. Cerebral ventriculomegaly is defined by atrial measurements 10 mm or more. Mild ventriculomegaly (MVM) is defined as measurements between 10 and 15 mm. Measurements are obtained from an axial plane at the level of the thalamic nuclei just below the standard image to measure the BPD (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2011-01-17T01:36:57Z" ; oboInOwl:hasDbXref "UMLS:C4023628" ; oboInOwl:hasExactSynonym "Mild foetal ventriculomegaly" ; oboInOwl:id "HP:0010952" ; a owl:Class ; rdfs:comment "A ventricular atrial diameter of more than 10 mm at 20-24 weeks of gestation has been accepted as defining ventriculomegaly because it represents at least 3 standard deviations above the mean (which is roughly 5 mm at 20-24 weeks of gestation). If the diameter is above 15 mm, the ventriculomegaly is considered to be severe. Amongst the most common causes of ventriculomegaly are impaired absorption of CSF, developmental cerebral defects, and destroyed brain tissue." ; rdfs:label "Mild fetal ventriculomegaly" ; rdfs:subClassOf obo:HP_0002119, obo:HP_0011425, obo:HP_0034206 . obo:HP_0010953 obo:IAO_0000115 "A form of hydrocephalus in which the flow of cerebrospinal fluid (CSF) within the cerebral ventricular system or in the outlets of the CSF to the arachnoid space is obstructed." ; dcterms:creator ; oboInOwl:creation_date "2011-01-17T02:22:26Z" ; oboInOwl:hasDbXref "MSH:D006849", "SNOMEDCT_US:230746009", "SNOMEDCT_US:82346000", "UMLS:C0549423" ; oboInOwl:id "HP:0010953" ; a owl:Class ; rdfs:comment "The most common form of noncommunicating hydrocephalus is obstructive and is caused by intraventricular or extraventricular mass-occupying lesions that disrupt the ventricular anatomy." ; rdfs:label "Noncommunicating hydrocephalus" ; rdfs:subClassOf obo:HP_0000238 . obo:HP_0010954 obo:IAO_0000115 "Underdevelopment of the right-sided structures of the heart." ; dcterms:creator ; oboInOwl:creation_date "2011-01-17T03:31:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:268180007", "SNOMEDCT_US:39589002", "UMLS:C0265856", "UMLS:C0344963" ; oboInOwl:hasExactSynonym "Hypoplastic right heart syndrome", "Underdeveloped right heart" ; oboInOwl:id "HP:0010954" ; a owl:Class ; rdfs:comment "Hypoplastic right heart syndrome (HRHS) causes inadequate blood flow to the lungs postnatally and thus leads to cyanosis. HRHS involves pulmonary valve atresia, hypoplasia of the right ventricle, hypoplasia of the tricuspid valve, and a small, hypoplastic pulmonary artery. As the ductus arteriosus closes postnatally, infants with HRHS become critically ill." ; rdfs:label "Hypoplastic right heart" ; rdfs:subClassOf obo:HP_0001961, obo:HP_0011723 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001062 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010955 obo:IAO_0000115 "The presence of a dilated urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T10:42:26Z" ; oboInOwl:hasDbXref "UMLS:C0549253" ; oboInOwl:id "HP:0010955" ; a owl:Class ; rdfs:label "Dilatation of the bladder" ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010956 obo:IAO_0000115 "Fetal megacystis is an abnormally enlarged bladder identified at any gestational age." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T10:43:58Z" ; oboInOwl:hasDbXref "MSH:C536139", "UMLS:C2931117" ; oboInOwl:hasExactSynonym "Foetal megacystis" ; oboInOwl:id "HP:0010956" ; a owl:Class ; rdfs:comment "Abnormal enlargement of the fetal bladder can be detected by prenatal ultrasound by fourteen weeks of gestation. In some cases, dilatation of the fetal bladder is transient and resolves without sequelae, and in other cases it is the earliest manifestation of bladder outlet obstruction." ; rdfs:label "Fetal megacystis" ; rdfs:subClassOf obo:HP_0010955 . obo:HP_0010957 obo:IAO_0000115 "A developmental defect resulting in an obstructing membrane in the posterior male urethra." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T10:51:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253900005", "UMLS:C0238506" ; oboInOwl:hasExactSynonym "Posterior urethral valve" ; oboInOwl:hasRelatedSynonym "Posterior urethral valves" ; oboInOwl:id "HP:0010957" ; a owl:Class ; rdfs:comment "Congenital posterior urethral valve is a cause of bladder outlet obstruction in male newborns. It results from a failure of resorption of the caudal end of the Wolffian duct into the primitive cloaca at the site of the future verumontanum in the posterior urethra (Following normal resorption of the posterior urethral valve there remain the posterior urethral folds, also called plicae colliculi)." ; rdfs:label "Congenital posterior urethral valve" ; rdfs:subClassOf obo:HP_0010481, obo:HP_0034378 . obo:HP_0010958 obo:IAO_0000115 "A bilateral form of agenesis of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T11:42:58Z" ; oboInOwl:hasDbXref "MSH:C536482", "SNOMEDCT_US:41962002", "UMLS:C1609433" ; oboInOwl:id "HP:0010958" ; a owl:Class ; rdfs:label "Bilateral renal agenesis" ; rdfs:subClassOf obo:HP_0000104 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0010959 obo:IAO_0000115 "Congenital pulmonary airway malformation (CPAM) - previously known as congenital cystic adenomatoid malformation (CCAM) - is a relatively rare developmental malformation of the lower respiratory tract. It is a hamartomatous, dysplastic developmental abnormality of the lung characterized by abnormal airway patterning during lung branching morphogenesis and is formed by abnormal branching of the immature bronchioles." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T11:56:02Z" ; oboInOwl:hasAlternativeId "HP:0006540", "HP:0006545" ; oboInOwl:hasDbXref "MSH:D015615", "SNOMEDCT_US:111318005", "UMLS:C0010668" ; oboInOwl:hasExactSynonym "CCAM", "Congenital cystic adenomatoid malformation of the lung", "Congenital cystic disease of the lung", "Cystic adenomatoid lung disease" ; oboInOwl:id "HP:0010959" ; a owl:Class ; rdfs:comment "The term CPAM has been recommended as being preferable to the term congenital cystic adenomatoid malformation, since the lesions are cystic or adenomatoid in only a limited number of cases. Only three types of CPAMs are distinguished at imaging: large cyst CPAM (type I) and small cyst CPAM (type II), which constitute macrocystic CPAMs; and microcystic or solid type (type III) lesions, which have cysts that are smaller than 5 mm in diameter, with no discernible cystic spaces." ; rdfs:label "Congenital pulmonary airway malformation" ; rdfs:subClassOf obo:HP_0005948, obo:HP_0034243 . obo:HP_0010960 obo:IAO_0000115 "The presence of microscopic cystic masses of nonfunctioning pulmonary tissue that lack an obvious communication with the tracheobronchial tree." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T12:28:51Z" ; oboInOwl:hasDbXref "MSH:D001998", "SNOMEDCT_US:18620009", "UMLS:C0006288" ; oboInOwl:id "HP:0010960" ; a owl:Class ; rdfs:comment "Typically, the lung tissue in BPS receives all or most of its blood supply from an anomalous systemic artery, with the origin of this artery being variable." ; rdfs:label "Bronchopulmonary sequestration" ; rdfs:subClassOf obo:HP_4000059 . obo:HP_0010961 obo:IAO_0000115 "A kind of bronchopulmonary sequestration that is incorporated into the normal surrounding lung." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T12:34:14Z" ; oboInOwl:hasDbXref "UMLS:C4023627" ; oboInOwl:id "HP:0010961" ; a owl:Class ; rdfs:comment "Intralobar sequestration (ILS) may be diagnosed on antenatal ultrasound screening. ILS can be asymptomatic in later life or can lead to signs and symptoms related to inadequate tracheobronchial drainage caused by the lesion of adjacent atelectatic lung." ; rdfs:label "Intralobar sequestration" ; rdfs:subClassOf obo:HP_0010960 . obo:HP_0010962 obo:IAO_0000115 "A kind of bronchopulmonary sequestration that is completely discrete from the normal lung and is surrounded by separate pleura." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T12:36:55Z" ; oboInOwl:hasDbXref "UMLS:C4023626" ; oboInOwl:id "HP:0010962" ; a owl:Class ; rdfs:comment "Extralobar sequestration (ELS) may be asymptomatic. Infants with symptomatic lesions may present with respiratory distress, pneumonia, feeding difficulties, hemorrhage, or even congestive heart failure. The sequestered lobe may cause substantial arteriovenous shunting, leading to high-output cardiac failure." ; rdfs:label "Extralobar sequestration" ; rdfs:subClassOf obo:HP_0010960 . obo:HP_0010963 obo:IAO_0000115 "By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-18T12:45:41Z" ; oboInOwl:hasDbXref "UMLS:C4023625" ; oboInOwl:hasExactSynonym "Absence of stomach bubble on foetal sonography", "Absent stomach bubble", "Non-visualisation of the fetal stomach", "Non-visualisation of the foetal stomach" ; oboInOwl:id "HP:0010963" ; a owl:Class ; rdfs:comment "The absence of stomach bubble on fetal sonography can be an indication of malformations such as esophageal atresia, especially in combination with polyhydramnios." ; rdfs:label "Absence of stomach bubble on fetal sonography" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0034207 . obo:HP_0010964 obo:IAO_0000115 "Any deviation from the normal concentration of a long-chain fatty acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T08:05:00Z" ; oboInOwl:hasDbXref "UMLS:C4023624" ; oboInOwl:id "HP:0010964" ; a owl:Class ; rdfs:comment "A long-chain fatty-acid is defined as an aliphatic monocarboxylic acid with a chain length of C13 to C18." ; rdfs:label "Abnormal circulating long-chain fatty-acid concentration" ; rdfs:subClassOf obo:HP_0004359 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010965 obo:IAO_0000115 "Any deviation from the normal concentration of phytanic acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T08:07:48Z" ; oboInOwl:hasDbXref "UMLS:C4023623" ; oboInOwl:hasExactSynonym "Abnormal circulating phytanic acid level" ; oboInOwl:id "HP:0010965" ; a owl:Class ; rdfs:comment "Phytanic acid is a branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15." ; rdfs:label "Abnormal circulating phytanic acid concentration" ; rdfs:subClassOf obo:HP_0010964 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0008152 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_16285 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010966 obo:IAO_0000115 "Any deviation from the normal concentration of a fatty acid anion in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T09:17:48Z" ; oboInOwl:hasDbXref "UMLS:C4021209" ; oboInOwl:hasExactSynonym "Abnormality of fatty acid anion" ; oboInOwl:id "HP:0010966" ; a owl:Class ; rdfs:comment "A fatty acid anion is the conjugate base of a fatty acid." ; rdfs:label "Abnormal circulating fatty-acid anion concentration" ; rdfs:subClassOf obo:HP_0004359, obo:HP_0010996 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0008152 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_28868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010967 obo:IAO_0000115 "Any deviation from the normal concentration of carnitine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T09:19:42Z" ; oboInOwl:hasDbXref "UMLS:C4020761", "UMLS:C4021855" ; oboInOwl:hasRelatedSynonym "Carnitine levels abnormal" ; oboInOwl:id "HP:0010967" ; a owl:Class ; rdfs:comment "L-carnitine (3-hydroxy-4-N.trimethylammonium butyrate) plays a key role in facilitating the transport of long-chain fatty acids from the cytosol into the mitochondrial matrix, where they undergo 13-oxidation." ; rdfs:label "Abnormal circulating carnitine concentration" ; rdfs:subClassOf obo:HP_0010966 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0009437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010968 obo:IAO_0000115 "An abnormality of liposaccharide metabolism." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T09:22:56Z" ; oboInOwl:hasDbXref "UMLS:C4023622" ; oboInOwl:id "HP:0010968" ; a owl:Class ; rdfs:label "Abnormality of liposaccharide metabolism" ; rdfs:subClassOf obo:HP_0032243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_1903509 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010969 obo:IAO_0000115 "An abnormality of glycolipid metabolism." ; dcterms:creator ; oboInOwl:creation_date "2011-01-27T09:25:31Z" ; oboInOwl:hasDbXref "UMLS:C4023621" ; oboInOwl:id "HP:0010969" ; a owl:Class ; rdfs:label "Abnormality of glycolipid metabolism" ; rdfs:subClassOf obo:HP_0032243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006664 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010970 obo:IAO_0000115 "An abnormality of an erythrocyte cell surface molecule." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T12:37:33Z" ; oboInOwl:hasDbXref "UMLS:C4023620" ; oboInOwl:id "HP:0010970" ; a owl:Class ; rdfs:comment "During development, the human immune system recognizes antigens of the body as 'self' and does not generate antibodies against them." ; rdfs:label "Blood group antigen abnormality" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0010971 obo:IAO_0000115 "Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T12:40:21Z" ; oboInOwl:hasDbXref "UMLS:C4023619" ; oboInOwl:id "HP:0010971" ; a owl:Class ; rdfs:label "Absence of Lutheran antigen on erythrocytes" ; rdfs:subClassOf obo:HP_0010970 . obo:HP_0010972 obo:IAO_0000115 "A kind of anemia characterized by inadequate production of erythrocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T02:24:54Z" ; oboInOwl:hasAlternativeId "HP:0005501", "HP:0005504", "HP:0005553" ; oboInOwl:hasDbXref "SNOMEDCT_US:70730006", "UMLS:C0392708", "UMLS:C0678199" ; oboInOwl:hasExactSynonym "Anaemia of inadequate production", "Anemia, dyserythropoietic", "Defective erythropoiesis", "Dyserythropoietic anaemia", "Dyserythropoietic anemia", "Ineffective erythropoiesis" ; oboInOwl:id "HP:0010972" ; a owl:Class ; rdfs:label "Anemia of inadequate production" ; rdfs:subClassOf obo:HP_0001903 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001511 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030218 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010974 obo:IAO_0000115 "An abnormality of myeloid leukocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T09:24:46Z" ; oboInOwl:hasDbXref "UMLS:C4023618" ; oboInOwl:hasExactSynonym "Abnormality of myeloid leukocytes" ; oboInOwl:id "HP:0010974" ; a owl:Class ; rdfs:comment "A myeloid leukocyte refers to a cell of the monocyte, granulocyte, or mast cell lineage." ; rdfs:label "Abnormal myeloid leukocyte morphology" ; rdfs:subClassOf obo:HP_0001881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010975 obo:IAO_0000115 "A deviation from the normal count of B cells, i.e., the cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T09:38:18Z" ; oboInOwl:hasDbXref "UMLS:C4021208" ; oboInOwl:hasExactSynonym "Abnormal number of B cells", "Abnormal numbers of B cells", "Abnormality of B cell count", "Abnormality of B cell numbers" ; oboInOwl:id "HP:0010975" ; a owl:Class ; rdfs:label "Abnormal B cell count" ; rdfs:subClassOf obo:HP_0002846, obo:HP_0040088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010976 obo:IAO_0000115 "An abnormal decrease from the normal count of B cells." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T09:44:11Z" ; oboInOwl:hasAlternativeId "HP:0002956" ; oboInOwl:hasDbXref "UMLS:C1855067" ; oboInOwl:hasExactSynonym "B cell deficiency", "B cell lymphopenia", "Decreased B cell count", "Low B cell count", "Reduction in B cell number" ; oboInOwl:id "HP:0010976" ; a owl:Class ; rdfs:comment "Plasma B cells differentiate from B cells and secrete large amounts of antibodies." ; rdfs:label "B lymphocytopenia" ; rdfs:subClassOf obo:HP_0001888, obo:HP_0010975 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010977 obo:IAO_0000115 "An abnormal functioning of phagocytosis. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-06T10:31:46Z" ; oboInOwl:hasDbXref "UMLS:C4023617" ; oboInOwl:id "HP:0010977" ; a owl:Class ; rdfs:label "Abnormal phagocytosis" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006909 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010978 obo:IAO_0000115 "A functional abnormality of the immune system." ; dcterms:creator ; oboInOwl:creation_date "2011-02-07T04:28:55Z" ; oboInOwl:hasDbXref "UMLS:C4023616" ; oboInOwl:id "HP:0010978" ; a owl:Class ; rdfs:label "Abnormality of immune system physiology" ; rdfs:subClassOf obo:HP_0002715 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002405 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010979 obo:IAO_0000115 "An abnormal increase or decrease in the level of lipoprotein cholesterol in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-02-07T09:47:29Z" ; oboInOwl:hasDbXref "UMLS:C4023615" ; oboInOwl:hasExactSynonym "Abnormality of the level of lipoprotein cholesterol" ; oboInOwl:id "HP:0010979" ; a owl:Class ; rdfs:comment "Lipoproteins transport fats (lipids) in the blood circulation. Lipids are insoluble in water, meaning that they could not be transported in the blood circulation on their own. There are five major types of lipoproteins: (i) chylomicrons; VLDL (very low-density lipoprotein); (iii) IDL (intermediate-density lipoprotein); (iv) LDL (low-density lipoprotein); and (v) HDL (high-density lipoprotein). Clinical measures assess the amount of cholesterol carried by different lipoproteins. For instance, LDL-cholesterol (LDL-C) is the maount of cholesterol carried by LDL." ; rdfs:label "Abnormality of lipoprotein cholesterol concentration" ; rdfs:subClassOf obo:HP_0003107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_50404 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010980 obo:IAO_0000115 "An abnormal increase in the level of lipoprotein cholesterol in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-02-07T10:56:30Z" ; oboInOwl:hasDbXref "MSH:D006951", "SNOMEDCT_US:3744001", "UMLS:C0020476" ; oboInOwl:id "HP:0010980" ; a owl:Class ; rdfs:label "Hyperlipoproteinemia" ; rdfs:subClassOf obo:HP_0010979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_50404 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010981 obo:IAO_0000115 "An abnormal decrease in the level of lipoprotein cholesterol in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-02-07T11:01:50Z" ; oboInOwl:hasDbXref "MSH:D007009", "SNOMEDCT_US:267436001", "SNOMEDCT_US:363140000", "UMLS:C0020623" ; oboInOwl:hasExactSynonym "Lack of fat in blood" ; oboInOwl:id "HP:0010981" ; a owl:Class ; rdfs:label "Hypolipoproteinemia" ; rdfs:subClassOf obo:HP_0010979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_50404 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010982 obo:IAO_0000115 "A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T10:12:39Z" ; oboInOwl:hasDbXref "MSH:D020412", "UMLS:C1148552" ; oboInOwl:hasRelatedSynonym "Common, complex disease", "Complex disease", "Multifactorial inheritance" ; oboInOwl:id "HP:0010982" ; a owl:Class ; rdfs:label "Polygenic inheritance" ; rdfs:subClassOf obo:HP_0001426 . obo:HP_0010983 obo:IAO_0000115 "A type of multifactorial inheritance governed by the simultaneous action of a few gene loci. It is recommended this term be used for traits governed by three loci, although it is noted that usage of this term in the literature is not uniform." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T10:13:16Z" ; oboInOwl:hasDbXref "MSH:D020412", "UMLS:C1136026" ; oboInOwl:id "HP:0010983" ; a owl:Class ; rdfs:label "Oligogenic inheritance" ; rdfs:subClassOf obo:HP_0001426 . obo:HP_0010984 obo:IAO_0000115 "A type of multifactorial inheritance governed by the simultaneous action of two gene loci." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T10:13:54Z" ; oboInOwl:hasDbXref "UMLS:C4023614" ; oboInOwl:id "HP:0010984" ; a owl:Class ; rdfs:label "Digenic inheritance" ; rdfs:subClassOf obo:HP_0001426 . obo:HP_0010985 obo:IAO_0100001 "HP:0000005" ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T10:16:28Z" ; oboInOwl:id "HP:0010985" ; a owl:Class ; rdfs:label "obsolete Gonosomal inheritance" ; owl:deprecated true . obo:HP_0010987 obo:IAO_0000115 "An abnormality of the morphology or counts of the cells that make up the immune system." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T12:49:47Z" ; oboInOwl:hasDbXref "UMLS:C4023612" ; oboInOwl:id "HP:0010987" ; a owl:Class ; rdfs:label "Abnormal cellular immune system morphology" ; rdfs:subClassOf obo:HP_0032251 . obo:HP_0010988 obo:IAO_0000115 "An abnormality of the extrinsic pathway (also known as the tissue factor pathway) of the coagulation cascade." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T01:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4023611" ; oboInOwl:id "HP:0010988" ; a owl:Class ; rdfs:comment "The extrinsic pathway is a protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." ; rdfs:label "Abnormality of the extrinsic pathway" ; rdfs:subClassOf obo:HP_0003256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007598 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010989 obo:IAO_0000115 "An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T04:26:55Z" ; oboInOwl:hasDbXref "UMLS:C4023610" ; oboInOwl:id "HP:0010989" ; a owl:Class ; rdfs:comment "The intrinsic pathway requires coagulation factors VIII, IX, X, XI, and XII, as well as the proteins prekallikrein (PK) and high-molecular-weight kininogen (HK or HMWK), in addition to calcium ions and phospholipids secreted from platelets." ; rdfs:label "Abnormality of the intrinsic pathway" ; rdfs:subClassOf obo:HP_0003256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010990 obo:IAO_0000115 "An abnormality of blood coagulation, common pathway." ; dcterms:creator ; oboInOwl:creation_date "2011-02-08T04:31:53Z" ; oboInOwl:hasDbXref "UMLS:C4023609" ; oboInOwl:id "HP:0010990" ; a owl:Class ; rdfs:comment "The common pathway is a protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." ; rdfs:label "Abnormality of the common coagulation pathway" ; rdfs:subClassOf obo:HP_0003256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0072377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010991 obo:IAO_0000115 "An abnormality of the abdominal musculature." ; dcterms:creator ; oboInOwl:creation_date "2011-02-09T08:05:11Z" ; oboInOwl:hasDbXref "UMLS:C4023608" ; oboInOwl:hasExactSynonym "Abnormality of the abdominal musculature" ; oboInOwl:id "HP:0010991" ; a owl:Class ; rdfs:label "Abnormal morphology of the abdominal musculature" ; rdfs:subClassOf obo:HP_0004298, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002343 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010992 obo:IAO_0000115 "Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing." ; dcterms:creator ; oboInOwl:creation_date "2011-02-09T12:13:46Z" ; oboInOwl:hasDbXref "MSH:D014550", "SNOMEDCT_US:22220005", "UMLS:C0042025" ; oboInOwl:id "HP:0010992" ; a owl:Class ; rdfs:label "Stress urinary incontinence" ; rdfs:subClassOf obo:HP_0000020 . obo:HP_0010993 obo:IAO_0000115 "An abnormality of the cerebral subcortex." ; dcterms:creator ; oboInOwl:creation_date "2011-02-09T10:32:54Z" ; oboInOwl:hasDbXref "UMLS:C4021207" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral medulla", "Abnormality of the cerebral subcortex" ; oboInOwl:id "HP:0010993" ; a owl:Class ; rdfs:comment "The cerebral subcortex contains the basal ganglia and the cerebral white matter." ; rdfs:label "Abnormal cerebral subcortex morphology" ; rdfs:subClassOf obo:HP_0002060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010994 obo:IAO_0000115 "Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens." ; dcterms:creator ; oboInOwl:creation_date "2011-02-10T08:31:42Z" ; oboInOwl:hasDbXref "UMLS:C4023607" ; oboInOwl:hasExactSynonym "Abnormality of the neostriatum", "Abnormality of the striate nucleus", "Abnormality of the striatum" ; oboInOwl:id "HP:0010994" ; a owl:Class ; rdfs:comment "The striatum (also known as the neostriatum or striate nucleus) contains the caudate nucleus and putamen, which are separated from one another by a white matter tract called the internal capsule. The striatum is part of the basal ganglia and receives input from the cerebral cortex. Essentially all cortical areas (sensory, motor and associational) project to the striatum. The other major input to the striatum comes from the thalamus, particularly the intralaminar thalamic nuclei." ; rdfs:label "Abnormal corpus striatum morphology" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010995 obo:IAO_0000115 "Any deviation from the normal concentration of a dicarboxylic acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-10T02:01:02Z" ; oboInOwl:hasDbXref "UMLS:C4023606" ; oboInOwl:id "HP:0010995" ; a owl:Class ; rdfs:comment "A dicarboxylic acid is an oxoacid containing two carboxy groups." ; rdfs:label "Abnormal circulating dicarboxylic acid concentration" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0043648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010996 obo:IAO_0000115 "Any deviation from the normal concentration of a monocarboxylic acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-10T02:20:42Z" ; oboInOwl:hasDbXref "UMLS:C4023605" ; oboInOwl:id "HP:0010996" ; a owl:Class ; rdfs:label "Abnormal circulating monocarboxylic acid concentration" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0032787 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0010997 obo:IAO_0000115 "Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with ionizing radiation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-10T06:10:33Z" ; oboInOwl:hasDbXref "UMLS:C4021206" ; oboInOwl:hasExactSynonym "Chromosomal breakage induced by ionising radiation", "Increased cellular radiosensitivity", "Radiation-induced chromosome instability" ; oboInOwl:id "HP:0010997" ; a owl:Class ; rdfs:comment "Increased tendency to chromosomal breakage induced by crosslinking agents is typical for several disorders including ataxia teleangiectasia and Nijmegen breakage syndrome." ; rdfs:label "Chromosomal breakage induced by ionizing radiation" ; rdfs:subClassOf obo:HP_0040012 . obo:HP_0010998 obo:IAO_0000115 "An increase in the number of spontaneous sister chromatid exchanges observed in cell culture of lymphocytes or other cells." ; dcterms:creator ; oboInOwl:creation_date "2011-02-10T06:14:16Z" ; oboInOwl:hasDbXref "UMLS:C4023604" ; oboInOwl:id "HP:0010998" ; a owl:Class ; rdfs:comment "Increased susceptibility to spontaneous sister chromatid exchange is characteristic for Bloom syndrome." ; rdfs:label "Increased susceptibility to spontaneous sister chromatid exchange" ; rdfs:subClassOf obo:HP_0003220 . obo:HP_0010999 dcterms:creator ; oboInOwl:creation_date "2011-02-13T11:28:03Z" ; oboInOwl:hasDbXref "UMLS:C4023603" ; oboInOwl:hasExactSynonym "Absent optic tract" ; oboInOwl:id "HP:0010999" ; a owl:Class ; rdfs:label "Aplasia of the optic tract" ; rdfs:subClassOf obo:HP_0011000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011000 dcterms:creator ; oboInOwl:creation_date "2011-02-13T11:28:43Z" ; oboInOwl:hasDbXref "UMLS:C4023602" ; oboInOwl:hasExactSynonym "Absent/small optic tract", "Absent/underdeveloped optic tract" ; oboInOwl:id "HP:0011000" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the optic tract" ; rdfs:subClassOf obo:HP_0002977 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011001 obo:IAO_0000115 "An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often referred to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones." ; dcterms:creator ; oboInOwl:creation_date "2011-02-13T11:57:32Z" ; oboInOwl:hasAlternativeId "HP:0002796", "HP:0004350", "HP:0005711", "HP:0005741", "HP:0010738" ; oboInOwl:hasDbXref "MSH:D010026", "SNOMEDCT_US:49347007", "UMLS:C0029464" ; oboInOwl:hasExactSynonym "Increased bone density", "Increased bone mineral density", "Osteosclerosis", "Osteosclerosis of bones" ; oboInOwl:id "HP:0011001" ; a owl:Class ; rdfs:comment "This term may be merged with Increased bone density in the future or made obsolete." ; rdfs:label "Increased bone mineral density" ; rdfs:subClassOf obo:HP_0004348 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011002 obo:IAO_0000115 "Abnormally increased formation of dense trabecular bone tissue. Despite the increased density of bone tissue, osteopetrotic bones tend to be more fracture-prone than normal." ; dcterms:creator ; oboInOwl:creation_date "2011-02-13T11:58:36Z" ; oboInOwl:hasDbXref "MSH:D010022", "SNOMEDCT_US:1926006", "SNOMEDCT_US:367489004", "UMLS:C0029454" ; oboInOwl:hasExactSynonym "Harder, denser, fracture-prone bones" ; oboInOwl:hasRelatedSynonym "Albers-Schoenberg disease", "Albers-Schonberg disease", "Albers-Schönberg disease", "Marble bone disease" ; oboInOwl:id "HP:0011002" ; a owl:Class ; rdfs:label "Osteopetrosis" ; rdfs:subClassOf obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001788 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0011003 obo:IAO_0000115 "A severe form of myopia with greater than -6.00 diopters." ; dcterms:creator ; oboInOwl:creation_date "2011-02-13T12:56:48Z" ; oboInOwl:hasAlternativeId "HP:0000569" ; oboInOwl:hasDbXref "SNOMEDCT_US:34187009", "UMLS:C0271183" ; oboInOwl:hasExactSynonym "Severe myopia", "Severe myopia (> -6.00 diopters)", "Severe near sightedness", "Severely close sighted", "Severely near sighted" ; oboInOwl:id "HP:0011003" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "High myopia" ; rdfs:subClassOf obo:HP_0000545 . obo:HP_0011004 obo:IAO_0000115 "An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries." ; dcterms:creator ; oboInOwl:creation_date "2011-02-16T08:46:49Z" ; oboInOwl:hasAlternativeId "HP:0002620", "HP:0005114" ; oboInOwl:hasDbXref "Fyler:2600", "SNOMEDCT_US:234119001", "UMLS:C0151489", "UMLS:C4021205" ; oboInOwl:hasExactSynonym "Abnormal systemic artery morphology", "Abnormality of the systemic arterial tree", "Systemic artery abnormality" ; oboInOwl:hasRelatedSynonym "Arterial abnormalities" ; oboInOwl:id "HP:0011004" ; a owl:Class ; rdfs:label "Abnormal systemic arterial morphology" ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004571 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011005 obo:IAO_0000115 "A type of cirrhosis characterized by the presence of regenerative nodules of a variety of sizes." ; dcterms:creator ; oboInOwl:creation_date "2011-02-17T09:01:14Z" ; oboInOwl:hasDbXref "UMLS:C1392669" ; oboInOwl:id "HP:0011005" ; a owl:Class ; rdfs:comment "In mixed cirrhosis, there are regenerating nodules under and over 3 mm in size." ; rdfs:label "Mixed cirrhosis" ; rdfs:subClassOf obo:HP_0001394 . obo:HP_0011006 obo:IAO_0000115 "An abnormality of the neck musculature." ; dcterms:creator ; oboInOwl:creation_date "2011-02-19T11:15:01Z" ; oboInOwl:hasDbXref "UMLS:C4023601" ; oboInOwl:hasExactSynonym "Abnormality of cervical musculature", "Abnormality of the musculature of the neck", "Neck muscle issue" ; oboInOwl:id "HP:0011006" ; a owl:Class ; rdfs:label "Abnormal morphology of the musculature of the neck" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011008 obo:IAO_0000115 "The speed at which disease manifestations appear and develop." ; dcterms:creator ; oboInOwl:creation_date "2011-02-20T10:22:32Z" ; oboInOwl:hasDbXref "UMLS:C4021204" ; oboInOwl:hasExactSynonym "Speed of onset" ; oboInOwl:id "HP:0011008" ; a owl:Class ; rdfs:label "Temporal pattern" ; rdfs:subClassOf obo:HP_0031797 . obo:HP_0011009 obo:IAO_0000115 "Sudden appearance of disease manifestations over a short period of time." ; dcterms:creator ; oboInOwl:creation_date "2011-02-20T10:23:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:272118002", "UMLS:C0205178" ; oboInOwl:hasExactSynonym "Acute onset" ; oboInOwl:id "HP:0011009" ; a owl:Class ; rdfs:comment "The word acute is applied to different time scales depending on the disease or manifestation and does not have an exact definition in minutes, hours, or days." ; rdfs:label "Acute" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0011010 obo:IAO_0000115 "Slow, creeping onset, slow progress and long continuance of disease manifestations." ; dcterms:creator ; oboInOwl:creation_date "2011-02-20T10:25:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:90734009", "UMLS:C0205191" ; oboInOwl:hasExactSynonym "Chronic" ; oboInOwl:id "HP:0011010" ; a owl:Class ; rdfs:comment "According to the U.S. National Center for Health Statistics, a chronic condition is one lasting 3 months or more." ; rdfs:label "Chronic" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0011011 obo:IAO_0000115 "Somewhat rapid onset and change of disease manifestations." ; dcterms:creator ; oboInOwl:creation_date "2011-02-20T10:27:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19939008", "UMLS:C0205365" ; oboInOwl:id "HP:0011011" ; a owl:Class ; rdfs:comment "Subacute is between acute and chronic." ; rdfs:label "Subacute" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0011012 obo:IAO_0000115 "A deviation from the normal concentration of a polysaccharide in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-21T09:46:11Z" ; oboInOwl:hasDbXref "UMLS:C4023600" ; oboInOwl:id "HP:0011012" ; a owl:Class ; rdfs:label "Abnormal circulating polysaccharide concentration" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011013 obo:IAO_0000115 "A deviation from the normal concentration of a carbohydrate in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-21T09:47:27Z" ; oboInOwl:hasDbXref "UMLS:C4023599" ; oboInOwl:id "HP:0011013" ; a owl:Class ; rdfs:comment "An abnormality of the metabolism (include abnormality of the concentration) of a carbohydrate, including monosaccharides, oligosaccharides and polysaccharides, and substances derived from them." ; rdfs:label "Abnormal circulating carbohydrate concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011014 obo:IAO_0000115 "Abnormality of glucose homeostasis." ; dcterms:creator ; oboInOwl:creation_date "2011-02-21T10:37:21Z" ; oboInOwl:hasDbXref "UMLS:C4023598" ; oboInOwl:id "HP:0011014" ; a owl:Class ; rdfs:comment "An abnormality of any process involved in the maintenance of an internal steady state of glucose within an organism or cell." ; rdfs:label "Abnormal glucose homeostasis" ; rdfs:subClassOf obo:HP_0012337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042593 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011015 obo:IAO_0000115 "An abnormality of the concentration of glucose in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-02-21T10:41:13Z" ; oboInOwl:hasDbXref "UMLS:C4023597" ; oboInOwl:hasExactSynonym "Abnormality of blood glucose concentration" ; oboInOwl:id "HP:0011015" ; a owl:Class ; rdfs:label "Abnormal blood glucose concentration" ; rdfs:subClassOf obo:HP_0011014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17234 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011016 obo:IAO_0100001 "HP:0003076" ; dcterms:creator ; oboInOwl:creation_date "2011-02-21T11:09:32Z" ; oboInOwl:id "HP:0011016" ; a owl:Class ; rdfs:label "obsolete Abnormality of urine glucose concentration" ; owl:deprecated true . obo:HP_0011017 obo:IAO_0000115 "An abnormality in a cellular process." ; dcterms:creator ; oboInOwl:creation_date "2011-02-22T07:05:50Z" ; oboInOwl:hasAlternativeId "HP:0025462" ; oboInOwl:hasDbXref "UMLS:C4023595" ; oboInOwl:hasExactSynonym "Abnormality of cell physiology" ; oboInOwl:id "HP:0011017" ; a owl:Class ; rdfs:label "Abnormal cellular physiology" ; rdfs:subClassOf obo:HP_0001939, obo:HP_0025354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011018 obo:IAO_0000115 "An abnormality of the cell cycle." ; dcterms:creator ; oboInOwl:creation_date "2011-02-22T07:09:31Z" ; oboInOwl:hasDbXref "UMLS:C4023594" ; oboInOwl:hasExactSynonym "Abnormality of the cell cycle" ; oboInOwl:id "HP:0011018" ; a owl:Class ; rdfs:label "Abnormality of the cell cycle" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007049 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011019 obo:IAO_0000115 "An abnormality of chromosome condensation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-22T07:19:30Z" ; oboInOwl:hasDbXref "UMLS:C4023593" ; oboInOwl:id "HP:0011019" ; a owl:Class ; rdfs:label "Abnormality of chromosome condensation" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030261 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011020 obo:IAO_0000115 "An abnormality of the metabolism of mucopolysaccharide." ; dcterms:creator ; oboInOwl:creation_date "2011-02-23T07:58:02Z" ; oboInOwl:hasDbXref "UMLS:C4023592" ; oboInOwl:id "HP:0011020" ; a owl:Class ; rdfs:label "Abnormality of mucopolysaccharide metabolism" ; rdfs:subClassOf obo:HP_0004371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_1903510 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011021 dcterms:creator ; oboInOwl:creation_date "2011-02-28T08:46:34Z" ; oboInOwl:hasDbXref "UMLS:C4023591" ; oboInOwl:id "HP:0011021" ; a owl:Class ; rdfs:label "Abnormality of circulating enzyme level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0011022 obo:IAO_0000115 "A deviation from the normal concentration of an unsaturated fatty acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-28T09:04:58Z" ; oboInOwl:hasDbXref "UMLS:C4023590" ; oboInOwl:id "HP:0011022" ; a owl:Class ; rdfs:label "Abnormal circulating unsaturated fatty acid concentration" ; rdfs:subClassOf obo:HP_0004359 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0033559 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011023 obo:IAO_0000115 "Any deviation from the normal concentration of a prostaglandin in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-02-28T09:19:20Z" ; oboInOwl:hasDbXref "UMLS:C4023589" ; oboInOwl:id "HP:0011023" ; a owl:Class ; rdfs:label "Abnormal circulating prostaglandin circulation" ; rdfs:subClassOf obo:HP_0030361 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006693 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011024 obo:IAO_0000115 "An abnormality of the gastrointestinal tract." ; dcterms:creator ; oboInOwl:creation_date "2011-03-01T07:52:06Z" ; oboInOwl:hasDbXref "MSH:D004066", "MSH:D005767", "SNOMEDCT_US:119292006", "SNOMEDCT_US:25374005", "SNOMEDCT_US:53619000", "UMLS:C0012242", "UMLS:C0017178", "UMLS:C4023588" ; oboInOwl:hasExactSynonym "Abnormality of the GI tract", "Abnormality of the gastrointestinal tract" ; oboInOwl:hasRelatedSynonym "Digestive system disease", "Gastrointestinal disease" ; oboInOwl:id "HP:0011024" ; a owl:Class ; rdfs:label "Abnormality of the gastrointestinal tract" ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011025 obo:IAO_0000115 "Abnormal functionality of the cardiovascular system." ; dcterms:creator ; oboInOwl:creation_date "2011-03-03T10:23:19Z" ; oboInOwl:hasDbXref "UMLS:C4023587" ; oboInOwl:hasExactSynonym "Abnormality of cardiovascular system physiology" ; oboInOwl:id "HP:0011025" ; a owl:Class ; rdfs:label "Abnormal cardiovascular system physiology" ; rdfs:subClassOf obo:HP_0001626 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011026 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the vagina." ; dcterms:creator ; oboInOwl:creation_date "2011-03-02T06:17:46Z" ; oboInOwl:hasDbXref "UMLS:C4023586" ; oboInOwl:hasExactSynonym "Absent/small vagina", "Absent/underdeveloped vagina" ; oboInOwl:id "HP:0011026" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the vagina" ; rdfs:subClassOf obo:HP_0000142 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011027 obo:IAO_0000115 "An abnormality of the fallopian tube." ; dcterms:creator ; oboInOwl:creation_date "2011-03-02T06:36:01Z" ; oboInOwl:hasDbXref "UMLS:C0281842" ; oboInOwl:hasExactSynonym "Abnormality of the fallopian tube" ; oboInOwl:id "HP:0011027" ; a owl:Class ; rdfs:comment "The Fallopian tubes (also known as oviducts, uterine tubes, and salpinges) are ducts that lead from the ovaries into the uterus." ; rdfs:label "Abnormal fallopian tube morphology" ; rdfs:subClassOf obo:HP_0000008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011028 obo:IAO_0000115 "An abnormality of blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-03-03T10:25:21Z" ; oboInOwl:hasDbXref "UMLS:C4020760", "UMLS:C4023585" ; oboInOwl:hasRelatedSynonym "Blood circulation disorder" ; oboInOwl:id "HP:0011028" ; a owl:Class ; rdfs:label "Abnormality of blood circulation" ; rdfs:subClassOf obo:HP_0011025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0008015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011029 obo:IAO_0000115 "The presence of hemorrhage within the body." ; dcterms:creator ; oboInOwl:creation_date "2011-03-03T10:26:26Z" ; oboInOwl:hasDbXref "UMLS:C1390214" ; oboInOwl:hasExactSynonym "Internal bleeding", "Internal haemorrhage" ; oboInOwl:id "HP:0011029" ; a owl:Class ; rdfs:label "Internal hemorrhage" ; rdfs:subClassOf obo:HP_0001892, obo:HP_0011028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011030 obo:IAO_0000115 "An abnormality of the homeostasis (concentration) of transition element cation." ; dcterms:creator ; oboInOwl:creation_date "2011-03-04T07:59:31Z" ; oboInOwl:hasDbXref "UMLS:C4023584" ; oboInOwl:hasExactSynonym "Abnormality of transition element cation homeostasis" ; oboInOwl:id "HP:0011030" ; a owl:Class ; rdfs:label "Abnormal blood transition element cation concentration" ; rdfs:subClassOf obo:HP_0010929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33515 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011031 obo:IAO_0000115 "An abnormality of the homeostasis (concentration) of iron cation." ; dcterms:creator ; oboInOwl:creation_date "2011-03-04T08:01:07Z" ; oboInOwl:hasDbXref "UMLS:C4023583" ; oboInOwl:id "HP:0011031" ; a owl:Class ; rdfs:label "Abnormality of iron homeostasis" ; rdfs:subClassOf obo:HP_0011030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24875 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011032 obo:IAO_0000115 "An abnormality of the regulation of body fluids." ; dcterms:creator ; oboInOwl:creation_date "2011-03-05T09:09:27Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:1860003", "SNOMEDCT_US:190902006", "UMLS:C2364164" ; oboInOwl:hasExactSynonym "Abnormality of fluid regulation", "Fluid imbalance" ; oboInOwl:id "HP:0011032" ; a owl:Class ; rdfs:label "Abnormality of fluid regulation" ; rdfs:subClassOf obo:HP_0012337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0050878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011033 obo:IAO_0000115 "An impairment of a fructose metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2011-03-05T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4023581" ; oboInOwl:id "HP:0011033" ; a owl:Class ; rdfs:label "Impairment of fructose metabolism" ; rdfs:subClassOf obo:HP_0032245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011034 obo:IAO_0000115 "The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T10:56:39Z" ; oboInOwl:hasDbXref "MSH:D000686", "SNOMEDCT_US:17602002", "UMLS:C0002726" ; oboInOwl:hasExactSynonym "Amyloid disease" ; oboInOwl:id "HP:0011034" ; a owl:Class ; rdfs:comment "The medical literautre on amyloidosis is confused with clinical and histochemical designations used when the amyloid disease processes were poorly understood. To be designated an amyloid fibril protein, the protein must occur in tissue deposits and exhibit affinity for Congo red and green birefringence when viewed by polarisation microscopy." ; rdfs:label "Amyloidosis" ; rdfs:subClassOf obo:HP_0001939 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_34 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011035 obo:IAO_0000115 "An abnormality of the cortex of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T11:31:39Z" ; oboInOwl:hasDbXref "UMLS:C4023580" ; oboInOwl:hasExactSynonym "Abnormality of renal cortex morphology" ; oboInOwl:id "HP:0011035" ; a owl:Class ; rdfs:label "Abnormal renal cortex morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011036 obo:IAO_0000115 "An altered ability of the kidneys to void urine and/or specific substances." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T12:28:55Z" ; oboInOwl:hasDbXref "MP:0005555", "UMLS:C4023579" ; oboInOwl:id "HP:0011036" ; a owl:Class ; rdfs:label "Abnormality of renal excretion" ; rdfs:subClassOf obo:HP_0012211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0003014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011037 obo:IAO_0000115 "A decreased rate of urine production." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T12:33:12Z" ; oboInOwl:hasDbXref "UMLS:C3887784" ; oboInOwl:id "HP:0011037" ; a owl:Class ; rdfs:comment "A reduction in the overall amount of urine output." ; rdfs:label "Decreased urine output" ; rdfs:subClassOf obo:HP_0012590 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011038 obo:IAO_0000115 "An abnormality of renal absorption." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T12:38:04Z" ; oboInOwl:hasDbXref "UMLS:C4023578" ; oboInOwl:hasExactSynonym "Abnormal renal resorption", "Abnormality of renal resorption" ; oboInOwl:id "HP:0011038" ; a owl:Class ; rdfs:label "Abnormal renal tubular resorption" ; rdfs:subClassOf obo:HP_0000124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070293 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011039 obo:IAO_0000115 "An abnormality of the helix. The helix is the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe." ; dcterms:creator ; oboInOwl:creation_date "2011-03-06T04:41:34Z" ; oboInOwl:hasAlternativeId "HP:0000380" ; oboInOwl:hasDbXref "UMLS:C1856660" ; oboInOwl:hasExactSynonym "Abnormal helices", "Abnormality of the helix", "Helix abnormal" ; oboInOwl:id "HP:0011039" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal helix morphology" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011040 obo:IAO_0000115 "An abnormality of the intrahepatic bile duct." ; dcterms:creator ; oboInOwl:creation_date "2011-03-07T07:54:11Z" ; oboInOwl:hasDbXref "UMLS:C4023577" ; oboInOwl:hasExactSynonym "Abnormality of the intrahepatic bile duct" ; oboInOwl:id "HP:0011040" ; a owl:Class ; rdfs:label "Abnormal intrahepatic bile duct morphology" ; rdfs:subClassOf obo:HP_0012440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003704 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011041 obo:IAO_0000115 "Aplasia or developmental hypoplasia of the cervical vertebral column." ; dcterms:creator ; oboInOwl:creation_date "2011-03-09T08:29:34Z" ; oboInOwl:hasDbXref "UMLS:C4023576" ; oboInOwl:hasExactSynonym "Absent/small cervical spine", "Absent/underdeveloped cervical spine" ; oboInOwl:id "HP:0011041" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cervical spine" ; rdfs:subClassOf obo:HP_0008518, obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011042 obo:IAO_0000115 "An abnormal concentration of potassium." ; dcterms:creator ; oboInOwl:creation_date "2011-03-09T11:00:32Z" ; oboInOwl:hasDbXref "UMLS:C4023575" ; oboInOwl:hasExactSynonym "Abnormal blood K concentration", "Abnormality of potassium homeostasis" ; oboInOwl:id "HP:0011042" ; a owl:Class ; rdfs:label "Abnormal blood potassium concentration" ; rdfs:subClassOf obo:HP_0010930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29103 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011043 obo:IAO_0000115 "An abnormal concentration of corticotropin in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T07:46:59Z" ; oboInOwl:hasDbXref "UMLS:C4023574" ; oboInOwl:hasExactSynonym "Abnormality of circulating corticotropin level" ; oboInOwl:hasRelatedSynonym "Abnormality of circulating ACTH level", "Abnormality of circulating adrenocorticotropic hormone level", "Abnormality of circulating adrenocorticotropin level" ; oboInOwl:id "HP:0011043" ; a owl:Class ; rdfs:comment "Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. . It is a component of the hypothalamic-pituitary-adrenal axis and stimulates increased production and release of corticosteroids and cortisol from the adrenal cortex." ; rdfs:label "Abnormal circulating adrenocorticotropin concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011044 obo:IAO_0000115 "The presence of an altered number of of permanent teeth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T10:43:37Z" ; oboInOwl:hasDbXref "UMLS:C4023573" ; oboInOwl:hasExactSynonym "Abnormal complement of permanent teeth", "Abnormal number of adult teeth", "Abnormal number of permanent teeth", "Abnormal number of secondary dentition", "Abnormal permanent tooth count" ; oboInOwl:id "HP:0011044" ; a owl:Class ; rdfs:label "Abnormal number of permanent teeth" ; rdfs:subClassOf obo:HP_0006483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011045 obo:IAO_0000115 "Agenesis of upper secondary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:20:25Z" ; oboInOwl:hasDbXref "UMLS:C4023572", "UMLS:C4280358", "UMLS:C4280359" ; oboInOwl:hasExactSynonym "Agenesis of adult maxillary central incisor", "Failure of development of permanent maxillary central incisor" ; oboInOwl:hasRelatedSynonym "Absence of permanent maxillary central incisor", "Absence of permanent upper central incisor", "Absence of permanent upper front tooth", "Missing adult upper central incisor", "Missing permanent maxillary central incisor", "Missing permanent upper central incisor", "Missing permanent upper front tooth" ; oboInOwl:id "HP:0011045" ; a owl:Class ; rdfs:comment "This feature is to be distinguished from single central upper incisor, which is median." ; rdfs:label "Agenesis of permanent maxillary central incisor" ; rdfs:subClassOf obo:HP_0006293 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011046 obo:IAO_0000115 "Agenesis of upper central primary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:21:41Z" ; oboInOwl:hasDbXref "UMLS:C4023571", "UMLS:C4280357" ; oboInOwl:hasExactSynonym "Agenesis of deciduous maxillary central incisor", "Failure of development of deciduous maxillary central incisor", "Failure of development of primary maxillary central incisor" ; oboInOwl:hasRelatedSynonym "Absence of deciduous maxillary central incisor", "Absence of primary maxillary central incisor", "Absence of upper front baby tooth", "Missing deciduous maxillary central incisor", "Missing primary maxillary central incisor", "Missing upper front baby tooth", "Missing upper front milk tooth" ; oboInOwl:id "HP:0011046" ; a owl:Class ; rdfs:comment "This feature is to be distinguished from single central upper incisor, which is median." ; rdfs:label "Agenesis of primary maxillary central incisor" ; rdfs:subClassOf obo:HP_0006293 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018593 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011047 obo:IAO_0000115 "Agenesis of lower primary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:14:55Z" ; oboInOwl:hasDbXref "UMLS:C4023570", "UMLS:C4280355", "UMLS:C4280356" ; oboInOwl:hasExactSynonym "Agenesis of deciduous lower central incisor", "Agenesis of primary lower central incisor", "Failure of development of deciduous mandibular central incisor", "Failure of development of primary mandibular central incisor" ; oboInOwl:hasRelatedSynonym "Absence of deciduous mandibular central incisor", "Absence of primary mandibular central incisor", "Missing deciduous mandibular central incisor", "Missing lower central incisor milk tooth", "Missing lower front baby tooth", "Missing lower front milk tooth", "Missing lower front primary tooth", "Missing primary mandibular central incisor" ; oboInOwl:id "HP:0011047" ; a owl:Class ; rdfs:label "Agenesis of primary mandibular central incisor" ; rdfs:subClassOf obo:HP_0006355 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018595 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011048 obo:IAO_0000115 "Agenesis of lower secondary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:16:08Z" ; oboInOwl:hasDbXref "UMLS:C4023569", "UMLS:C4280354" ; oboInOwl:hasExactSynonym "Agenesis of adult mandibular central incisor", "Failure of development of permanent mandibular central incisor" ; oboInOwl:hasRelatedSynonym "Absence of permanent lower central incisor", "Absence of permanent lower front tooth", "Absence of permanent mandibular central incisor", "Missing adult lower central incisor", "Missing permanent lower central incisor", "Missing permanent lower front tooth", "Missing permanent mandibular central incisor" ; oboInOwl:id "HP:0011048" ; a owl:Class ; rdfs:label "Agenesis of permanent mandibular central incisor" ; rdfs:subClassOf obo:HP_0006355 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018568 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011049 obo:IAO_0000115 "Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:31:10Z" ; oboInOwl:hasDbXref "UMLS:C4023568", "UMLS:C4280353" ; oboInOwl:hasExactSynonym "Agenesis of deciduous maxillary lateral incisor", "Failure of development of deciduous maxillary lateral incisor", "Failure of development of primary maxillary lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of deciduous maxillary lateral incisor", "Absence of primary maxillary lateral incisor", "Missing deciduous maxillary lateral incisor", "Missing primary maxillary lateral incisor" ; oboInOwl:id "HP:0011049" ; a owl:Class ; rdfs:label "Agenesis of primary maxillary lateral incisor" ; rdfs:subClassOf obo:HP_0000690 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018594 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011050 obo:IAO_0000115 "Agenesis of one or more upper lateral secondary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:32:17Z" ; oboInOwl:hasDbXref "UMLS:C4023567", "UMLS:C4280352" ; oboInOwl:hasExactSynonym "Agenesis of permanent upper lateral incisor", "Failure of development of permanent maxillary lateral incisor", "Failure of development of permanent upper lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of permanent maxillary lateral incisor", "Missing permanent maxillary lateral incisor", "Missing permanent upper lateral incisor" ; oboInOwl:id "HP:0011050" ; a owl:Class ; rdfs:label "Agenesis of permanent maxillary lateral incisor" ; rdfs:subClassOf obo:HP_0000690 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016455 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011051 obo:IAO_0000115 "Agenesis of premolar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:36:44Z" ; oboInOwl:hasDbXref "UMLS:C4023566", "UMLS:C4280351" ; oboInOwl:hasExactSynonym "Agenesis of bicuspid", "Failure of development of bicuspid", "Failure of development of premolar" ; oboInOwl:hasRelatedSynonym "Absence of bicuspid", "Absence of premolar", "Missing bicuspid", "Missing premolar" ; oboInOwl:id "HP:0011051" ; a owl:Class ; rdfs:comment "Note that premolar teeth occur only in the permanent dentition." ; rdfs:label "Agenesis of premolar" ; rdfs:subClassOf obo:HP_0001592, obo:HP_0011076 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011052 obo:IAO_0000115 "Agenesis of maxillary premolar." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:39:06Z" ; oboInOwl:hasDbXref "UMLS:C4023565", "UMLS:C4280350" ; oboInOwl:hasExactSynonym "Agenesis of maxillary bicuspid", "Failure of development of maxillary bicuspid", "Failure of development of maxillary premolar" ; oboInOwl:hasRelatedSynonym "Absence of maxillary bicuspid", "Absence of maxillary premolar", "Absence of upper premolar", "Missing maxillary premolar", "Missing upper bicuspid", "Missing upper premolar" ; oboInOwl:id "HP:0011052" ; a owl:Class ; rdfs:comment "Note that premolar teeth occur only in the permanent dentition." ; rdfs:label "Agenesis of maxillary premolar" ; rdfs:subClassOf obo:HP_0011051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011053 obo:IAO_0000115 "Agenesis of mandibular premolar." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:40:37Z" ; oboInOwl:hasDbXref "UMLS:C4023564", "UMLS:C4280349" ; oboInOwl:hasExactSynonym "Failure of development of mandibular premolar" ; oboInOwl:hasRelatedSynonym "Absence of lower premolar", "Absence of mandibular premolar", "Missing lower premolar", "Missing mandibular premolar" ; oboInOwl:id "HP:0011053" ; a owl:Class ; rdfs:label "Agenesis of mandibular premolar" ; rdfs:subClassOf obo:HP_0011051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011054 obo:IAO_0000115 "Agenesis of molar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:41:46Z" ; oboInOwl:hasDbXref "UMLS:C4021203", "UMLS:C4280348" ; oboInOwl:hasExactSynonym "Absent molars", "Failure of development of molar" ; oboInOwl:hasRelatedSynonym "Absence of molar", "Missing molar" ; oboInOwl:id "HP:0011054" ; a owl:Class ; rdfs:label "Agenesis of molar" ; rdfs:subClassOf obo:HP_0001592, obo:HP_0011077 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003655 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011055 obo:IAO_0000115 "Agenesis of secondary molar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:44:27Z" ; oboInOwl:hasDbXref "UMLS:C4023563", "UMLS:C4280347" ; oboInOwl:hasExactSynonym "Agenesis of secondary molar", "Failure of development of permanent molar", "Failure of development of secondary molar" ; oboInOwl:hasRelatedSynonym "Absence of adult molar", "Absence of permanent molar", "Missing adult molar", "Missing permanent molar" ; oboInOwl:id "HP:0011055" ; a owl:Class ; rdfs:label "Agenesis of permanent molar" ; rdfs:subClassOf obo:HP_0011054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011056 obo:IAO_0000115 "Agenesis of either maxillary first permanent molar or mandibular first permanent molar or both." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:45:27Z" ; oboInOwl:hasDbXref "UMLS:C4023562", "UMLS:C4280346" ; oboInOwl:hasExactSynonym "Agenesis of six year molar", "Failure of development of first permanent molar", "Failure of development of six year molar" ; oboInOwl:hasRelatedSynonym "Absence of first permanent molar", "Absence of six year molar", "Missing first permanent molar", "Missing six year molar" ; oboInOwl:id "HP:0011056" ; a owl:Class ; rdfs:label "Agenesis of first permanent molar tooth" ; rdfs:subClassOf obo:HP_0011055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018608 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011057 obo:IAO_0000115 "Agenesis of either mandibular second permanent molar or maxillary second permanent molar." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T11:47:58Z" ; oboInOwl:hasDbXref "UMLS:C4023561", "UMLS:C4280257" ; oboInOwl:hasExactSynonym "Agenesis of twelve year molar", "Failure of development of second permanent molar", "Failure of development of twelve year molar" ; oboInOwl:hasRelatedSynonym "Absence of second permanent molar", "Absence of twelve year molar", "Missing second permanent molar", "Missing twelve year molar" ; oboInOwl:id "HP:0011057" ; a owl:Class ; rdfs:label "Agenesis of second permanent molar" ; rdfs:subClassOf obo:HP_0011055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018607 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011058 obo:IAO_0000115 "A generalized form of periodontitis." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T12:23:22Z" ; oboInOwl:hasBroadSynonym "Generalised gum disease", "Generalized gum disease", "Widespread gum disease" ; oboInOwl:hasDbXref "UMLS:C4023560", "UMLS:C4280345" ; oboInOwl:hasExactSynonym "Generalised periodontal disease", "Generalised periodontitis", "Generalized periodontal disease" ; oboInOwl:id "HP:0011058" ; a owl:Class ; rdfs:label "Generalized periodontitis" ; rdfs:subClassOf obo:HP_0000704 . obo:HP_0011059 obo:IAO_0000115 "A localized form of periodontitis." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T12:26:35Z" ; oboInOwl:hasBroadSynonym "Limited area of gum disease", "Localised gum disease", "Localized gum disease" ; oboInOwl:hasDbXref "UMLS:C4023559", "UMLS:C4280344" ; oboInOwl:hasExactSynonym "Localised periodontal disease", "Localised periodontitis", "Localized periodontal disease" ; oboInOwl:id "HP:0011059" ; a owl:Class ; rdfs:label "Localized periodontitis" ; rdfs:subClassOf obo:HP_0000704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000704 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000627 ] ) ] ] . obo:HP_0011060 obo:IAO_0000115 "Developmental dysplasia of dentin affecting only the primary dentition." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T12:26:32Z" ; oboInOwl:hasDbXref "MSH:D003805", "SNOMEDCT_US:109492001", "UMLS:C0011430", "UMLS:C4023558" ; oboInOwl:hasExactSynonym "Dentinogenesis imperfecta of baby teeth" ; oboInOwl:id "HP:0011060" ; a owl:Class ; rdfs:label "Dentinogenesis imperfecta limited to primary teeth" ; rdfs:subClassOf obo:HP_0000703 . obo:HP_0011061 obo:IAO_0000115 "An abnormality of the structure or composition of the teeth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T01:44:04Z" ; oboInOwl:hasDbXref "UMLS:C4023557" ; oboInOwl:hasExactSynonym "Abnormality of tooth part", "Abnormality of tooth structure" ; oboInOwl:id "HP:0011061" ; a owl:Class ; rdfs:label "Abnormality of dental structure" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011062 obo:IAO_0000115 "Misaligned incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T01:57:43Z" ; oboInOwl:hasBroadSynonym "Abnormality of position of incisors", "Malposition of incisors" ; oboInOwl:hasDbXref "UMLS:C4023556", "UMLS:C4280343" ; oboInOwl:hasExactSynonym "Abnormality of alignment of incisors", "Crooked front teeth", "Crooked incisors", "Misalignment of incisors" ; oboInOwl:id "HP:0011062" ; a owl:Class ; rdfs:label "Misalignment of incisors" ; rdfs:subClassOf obo:HP_0000676, obo:HP_0000692 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001654 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011063 obo:IAO_0000115 "An abnormality of morphology of the incisor tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:06:54Z" ; oboInOwl:hasDbXref "UMLS:C4023555" ; oboInOwl:hasExactSynonym "Abnormality of incisor morphology", "Abnormality of shape of incisor" ; oboInOwl:id "HP:0011063" ; a owl:Class ; rdfs:label "Abnormal incisor morphology" ; rdfs:subClassOf obo:HP_0000676, obo:HP_0006482 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011064 obo:IAO_0000115 "The presence of an altered number of the incisor teeth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:09:16Z" ; oboInOwl:hasDbXref "UMLS:C4023554" ; oboInOwl:hasExactSynonym "Abnormal number of front teeth", "Abnormal number of incisors" ; oboInOwl:id "HP:0011064" ; a owl:Class ; rdfs:label "Abnormal number of incisors" ; rdfs:subClassOf obo:HP_0000676, obo:HP_0006483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011065 obo:IAO_0000115 "An abnormal conical morphology of the incisor tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:14:34Z" ; oboInOwl:hasAlternativeId "HP:0000673", "HP:0006345", "HP:0011066" ; oboInOwl:hasDbXref "UMLS:C1856136", "UMLS:C4020759", "UMLS:C4280341", "UMLS:C4280342" ; oboInOwl:hasExactSynonym "Cone shaped front tooth", "Conoid incisor", "Peg shaped incisors", "Peg-shaped incisors", "Shark tooth incisor" ; oboInOwl:hasRelatedSynonym "Peg shaped front tooth", "Pointed front tooth", "Pointed incisor" ; oboInOwl:id "HP:0011065" ; a owl:Class ; rdfs:comment "Conical incisors are incisors that are round in cross-sectional views of the crown or that have a rounded appearance. Conical incisors may have a pointed shape that tapers to a point at the tip of the tooth. One speaks of conical incisor for a conical shaped tooth that is located in the region where incisors normally are." ; rdfs:label "Conical incisor" ; rdfs:subClassOf obo:HP_0000698, obo:HP_0011063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011067 obo:IAO_0000115 "A supernumerary tooth in the midline between the maxillary central incisors." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:38:59Z" ; oboInOwl:hasBroadSynonym "Extra tooth", "Extra tooth in the midline" ; oboInOwl:hasDbXref "MSH:D014096", "SNOMEDCT_US:17802000", "SNOMEDCT_US:266414008", "SNOMEDCT_US:367534004", "SNOMEDCT_US:8666004", "UMLS:C0040457", "UMLS:C0266030", "UMLS:C4280340" ; oboInOwl:hasExactSynonym "Median supernumary tooth", "Midline supernumary tooth" ; oboInOwl:hasNarrowSynonym "Mesiodentes" ; oboInOwl:id "HP:0011067" ; a owl:Class ; rdfs:comment "A mesiodens is not a supernumerary incisor (i.e., it does not have the morphology of an incisor). Rather, it is a conoid, extra tooth located between the maxillary central incisors. Mesiodens is the most common supernumerary tooth. Typically, they are small. They are usually conical in shape but may have heterogeneous forms. Mesiodens may remain unerupted and cause failure of a permanent incisor to erupt. Mesiodens may develop in an inverted position." ; rdfs:label "Mesiodens" ; rdfs:subClassOf obo:HP_0011069 . obo:HP_0011068 obo:IAO_0000115 "The presence of an odontoma." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:40:52Z" ; oboInOwl:hasDbXref "MSH:D009810", "SNOMEDCT_US:79074005", "UMLS:C0028882" ; oboInOwl:hasRelatedSynonym "Odontomas" ; oboInOwl:id "HP:0011068" ; a owl:Class ; rdfs:comment "MPATH defines odontoma as a hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma)." ; rdfs:label "Odontoma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100612 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:MPATH_387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011069 obo:IAO_0000115 "The presence of one or more teeth additional to the normal number." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T02:52:19Z" ; oboInOwl:hasAlternativeId "HP:0000672" ; oboInOwl:hasDbXref "MSH:D014096", "SNOMEDCT_US:266414008", "SNOMEDCT_US:367534004", "SNOMEDCT_US:8666004", "UMLS:C0040457" ; oboInOwl:hasExactSynonym "Extra teeth", "Hyperdontia", "Increased number of teeth", "Increased tooth count", "Supernumerary teeth", "Supplemental dentition", "Supplemental teeth", "Tooth, supernumerary" ; oboInOwl:hasNarrowSynonym "Supernumary dentition", "Supernumary teeth" ; oboInOwl:hasRelatedSynonym "More teeth than normal" ; oboInOwl:id "HP:0011069" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Age-related physiological sequential eruption should be taken into account during evaluation. The type and the location of the additional tooth/teeth should be added to the description. Supernumerary teeth are uncommon (in 0.21% of deciduous dentitions and in 0.9% of permanent dentitions), and often abnormal positioning of a normal number of teeth is wrongly classified as supernumerary teeth. Supernumerary teeth are most frequent in the upper maxilla, and typically, a single additional tooth is present. We discourage the use of distodens, distomolars (an extra fourth molar posterior to the third molar), paramolars (supernumerary tooth in the molar region) but rather to mention the presence of the supernumerary tooth mesial to or distal to a tooth from the normal series. Diagnosing a supernumerary tooth may require radiographic examination. A supernumerary tooth present between the maxillary central incisors is called mesiodens." ; rdfs:label "Supernumerary tooth" ; rdfs:subClassOf obo:HP_0006483 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011070 obo:IAO_0000115 "An abnormality of morphology of molar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T03:45:51Z" ; oboInOwl:hasDbXref "UMLS:C4023553" ; oboInOwl:hasExactSynonym "Abnormal shape of molar tooth", "Abnormality of molar morphology" ; oboInOwl:id "HP:0011070" ; a owl:Class ; rdfs:label "Abnormal molar morphology" ; rdfs:subClassOf obo:HP_0006482, obo:HP_0011077 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003655 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011071 obo:IAO_0000115 "An abnormality of morphology of permanent molar." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T03:48:43Z" ; oboInOwl:hasDbXref "UMLS:C4023552" ; oboInOwl:hasExactSynonym "Abnormality of shape of adult molar", "Abnormality of shape of permanent molar" ; oboInOwl:id "HP:0011071" ; a owl:Class ; rdfs:label "Abnormality of permanent molar morphology" ; rdfs:subClassOf obo:HP_0011070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013618 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011072 dcterms:creator ; oboInOwl:creation_date "2011-03-10T03:56:41Z" ; oboInOwl:hasDbXref "MSH:C538215", "SNOMEDCT_US:109493006", "UMLS:C0399379", "UMLS:C4082200" ; oboInOwl:hasExactSynonym "Absence of tooth root", "Agenesis of tooth root", "Aplasia of tooth root", "Missing tooth root", "Rootless teeth", "Teeth without roots" ; oboInOwl:hasRelatedSynonym "Tooth with dentin dysplasia type i" ; oboInOwl:id "HP:0011072" ; a owl:Class ; rdfs:label "Rootless teeth" ; rdfs:subClassOf obo:HP_0006486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011073 obo:IAO_0000115 "A developmental defect of tooth color." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T05:20:03Z" ; oboInOwl:hasDbXref "UMLS:C4023551" ; oboInOwl:hasExactSynonym "Abnormality of dental color", "Abnormality of dental colour", "Abnormality of dental shade", "Abnormality of tooth color", "Abnormality of tooth colour", "Abnormality of tooth shade" ; oboInOwl:id "HP:0011073" ; a owl:Class ; rdfs:label "Abnormality of dental color" ; rdfs:subClassOf obo:HP_0011061 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011074 obo:IAO_0000115 "A localized form of developmental hypoplasia of the dental enamel." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T05:13:09Z" ; oboInOwl:hasDbXref "UMLS:C4023550", "UMLS:C4280339" ; oboInOwl:hasExactSynonym "Localised hypoplasia of dental enamel", "Localised hypoplasia of tooth enamel", "Localized hypoplasia of tooth enamel" ; oboInOwl:hasRelatedSynonym "Localised dysplasia of tooth enamel", "Localized dysplasia of tooth enamel" ; oboInOwl:id "HP:0011074" ; a owl:Class ; rdfs:label "Localized hypoplasia of dental enamel" ; rdfs:subClassOf obo:HP_0006297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001752 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000627 ] ) ] ] . obo:HP_0011075 obo:IAO_0000115 "A green staining of teeth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-10T05:23:18Z" ; oboInOwl:hasDbXref "UMLS:C4023549" ; oboInOwl:hasExactSynonym "Green colored teeth", "Green coloured teeth", "Green teeth", "Green tooth shade" ; oboInOwl:id "HP:0011075" ; a owl:Class ; rdfs:comment "Green teeth are a rare finding in children with neonatal hyperbilirubinaemia due to blood group incompatibility, sepsis-induced cholestasis or biliary atresia. Rarely, green staining of the teeth may be seen with cholestasis and sepsis." ; rdfs:label "Green teeth" ; rdfs:subClassOf obo:HP_0011073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000320 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011076 obo:IAO_0000115 "An abnormality of premolar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T09:56:17Z" ; oboInOwl:hasDbXref "UMLS:C4023548" ; oboInOwl:hasExactSynonym "Abnormality of bicuspid", "Abnormality of premolar" ; oboInOwl:id "HP:0011076" ; a owl:Class ; rdfs:label "Abnormality of premolar" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011077 obo:IAO_0000115 "An abnormality of molar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T09:57:49Z" ; oboInOwl:hasDbXref "UMLS:C4023547" ; oboInOwl:hasExactSynonym "Abnormality of molar" ; oboInOwl:id "HP:0011077" ; a owl:Class ; rdfs:label "Abnormality of molar" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003655 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011078 obo:IAO_0000115 "An abnormality of canine tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T09:58:41Z" ; oboInOwl:hasDbXref "UMLS:C4023546" ; oboInOwl:hasExactSynonym "Abnormality of canine", "Abnormality of eye tooth" ; oboInOwl:id "HP:0011078" ; a owl:Class ; rdfs:label "Abnormality of canine" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003674 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011079 obo:IAO_0000115 "A tooth that has not erupted because of local impediments (overcrowding or fibrous gum overgrowth)." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T10:18:55Z" ; oboInOwl:hasBroadSynonym "Buried tooth" ; oboInOwl:hasDbXref "MSH:D014095", "SNOMEDCT_US:129263008", "SNOMEDCT_US:235104008", "UMLS:C0040456", "UMLS:C4280338" ; oboInOwl:hasExactSynonym "Impacted tooth", "Retained tooth" ; oboInOwl:id "HP:0011079" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Impacted tooth" ; rdfs:subClassOf obo:HP_0000706 . obo:HP_0011080 obo:IAO_0000115 "An abnormality of morphology of premolar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T10:33:42Z" ; oboInOwl:hasDbXref "UMLS:C4023545" ; oboInOwl:hasExactSynonym "Abnormality of bicuspid morphology", "Abnormality of premolar morphology", "Abnormality of shape of bicuspid", "Abnormality of shape of premolar" ; oboInOwl:id "HP:0011080" ; a owl:Class ; rdfs:label "Abnormal premolar morphology" ; rdfs:subClassOf obo:HP_0006482, obo:HP_0011076 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011081 obo:IAO_0000115 "Increased size of the incisor tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T10:39:44Z" ; oboInOwl:hasBroadSynonym "Hyperplasia of incisor", "Hypertrophy of incisor", "Increased size of incisor", "Large incisor" ; oboInOwl:hasDbXref "UMLS:C4023544", "UMLS:C4280337" ; oboInOwl:hasExactSynonym "Increased width of incisor" ; oboInOwl:id "HP:0011081" ; a owl:Class ; rdfs:label "Incisor macrodontia" ; rdfs:subClassOf obo:HP_0001572, obo:HP_0011063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011082 obo:IAO_0000115 "An abnormal conical morphology of the primary incisor." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T11:06:57Z" ; oboInOwl:hasDbXref "UMLS:C4023543" ; oboInOwl:hasExactSynonym "Cone shaped front baby tooth", "Conical deciduous incisor", "Conoid primary incisor", "Primary front shark tooth" ; oboInOwl:hasRelatedSynonym "Peg shaped front baby tooth", "Peg shaped primary incisor", "Pointed front baby tooth", "Pointed primary incisor" ; oboInOwl:id "HP:0011082" ; a owl:Class ; rdfs:label "Conical primary incisor" ; rdfs:subClassOf obo:HP_0011065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011083 obo:IAO_0000115 "An abnormal conical morphology of either maxillary primary incisor tooth or maxillary permanent incisor tooth or both." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T11:36:11Z" ; oboInOwl:hasDbXref "UMLS:C4023542" ; oboInOwl:hasExactSynonym "Cone shaped maxillary incisor", "Cone shaped upper front tooth", "Conoid maxillary incisor", "Upper front shark tooth" ; oboInOwl:hasRelatedSynonym "Peg shaped upper front tooth", "Pointed maxillary incisor", "Pointed upper front tooth" ; oboInOwl:id "HP:0011083" ; a owl:Class ; rdfs:label "Conical maxillary incisor" ; rdfs:subClassOf obo:HP_0011065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011084 obo:IAO_0000115 "A form of hypomineralization of enamel characterized by reduced calcification." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T12:08:46Z" ; oboInOwl:hasDbXref "UMLS:C4023541" ; oboInOwl:hasExactSynonym "Decreased enamel calcification", "Poorly calcified tooth enamel" ; oboInOwl:id "HP:0011084" ; a owl:Class ; rdfs:label "Hypocalcification of dental enamel" ; rdfs:subClassOf obo:HP_0006285 . obo:HP_0011085 obo:IAO_0000115 "A form of hypomineralization of enamel characterized by a chalky appearance of the enamel with orange, brown, or white color." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T12:10:33Z" ; oboInOwl:hasDbXref "UMLS:C4023540", "UMLS:C4280266", "UMLS:C4280336" ; oboInOwl:hasExactSynonym "Immature tooth enamel" ; oboInOwl:hasNarrowSynonym "Soft teeth", "Soft tooth enamel" ; oboInOwl:id "HP:0011085" ; a owl:Class ; rdfs:comment "Radiographically there is normal thickness of enamel and the enamel is slightly more radiolucent than dentin." ; rdfs:label "Hypomature dental enamel" ; rdfs:subClassOf obo:HP_0006285 . obo:HP_0011086 obo:IAO_0000115 "Developmental dysplasia of dentin or both the primary dentition and the permanent dentition." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T12:28:37Z" ; oboInOwl:hasDbXref "UMLS:C4023539" ; oboInOwl:hasExactSynonym "Dentinogenesis imperfecta of adult and baby teeth", "Dentinogenesis imperfecta of both sets of teeth" ; oboInOwl:id "HP:0011086" ; a owl:Class ; rdfs:label "Dentinogenesis imperfecta of primary and permanent teeth" ; rdfs:subClassOf obo:HP_0000703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011087 obo:IAO_0000115 "Talon cusp is an accessory cusp located near the cingulum (the portion of the lingual or palatal aspect of the tooth that forms a convex protuberance at the cervical third of the anatomic crown)." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:00:28Z" ; oboInOwl:hasBroadSynonym "Extra cusp on inside of front tooth" ; oboInOwl:hasDbXref "SNOMEDCT_US:234955005", "SNOMEDCT_US:63691004", "UMLS:C0266034", "UMLS:C0399357", "UMLS:C4280335" ; oboInOwl:hasExactSynonym "Dens evaginatus", "Talon cusps" ; oboInOwl:id "HP:0011087" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Talon cusp" ; rdfs:subClassOf obo:HP_0033777 . obo:HP_0011088 obo:IAO_0000115 "An abnormality of the incisor characterized by invagination of the enamel, giving a radiographic appearance that suggests a tooth within a tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:07:28Z" ; oboInOwl:hasDbXref "MSH:D003719", "SNOMEDCT_US:55197001", "UMLS:C0011320" ; oboInOwl:hasExactSynonym "Dens invaginatus", "Tooth within a tooth" ; oboInOwl:id "HP:0011088" ; a owl:Class ; rdfs:comment "Dens in dente is Latin for tooth inside of tooth. Dens in dente results from an invagination of the enamel organ into the dental papilla, extending into the root before initiation of mineralization. The permanent maxillary lateral incisors are the most frequently involved teeth, but it can occur in any tooth type. It occurs more frequently in the permanent dentition and in maxillary teeth. The diagnosis dens in dente needs to be confirmed by X-rays." ; rdfs:label "Dens in dente" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0011089 obo:IAO_0000115 "Fusion of two adjacent teeth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:13:26Z" ; oboInOwl:hasDbXref "MSH:D005671", "SNOMEDCT_US:1744008", "UMLS:C0016873" ; oboInOwl:hasExactSynonym "Conjoined teeth", "Double tooth", "Teeth, double", "Twinning tooth" ; oboInOwl:id "HP:0011089" ; a owl:Class ; rdfs:comment "The fusion can be complete or be limited to the crown or the root. Typically, incisors and canines form double teeth. Double teeth are more common in the deciduous dentition and rare in the permanent dentition. Double teeth encompasses fusion, concrescence, and gemination of teeth, which some authors describe with the twinning." ; rdfs:label "Double tooth" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0011090 obo:IAO_0000115 "The union of two separately developing tooth germs typically leading to one less tooth than normal in the affected dental arch." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:17:04Z" ; oboInOwl:hasDbXref "MSH:D005671", "SNOMEDCT_US:1744008", "UMLS:C0016873" ; oboInOwl:hasExactSynonym "Fused teeth", "Fusion of teeth", "Joined teeth" ; oboInOwl:id "HP:0011090" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fused teeth" ; rdfs:subClassOf obo:HP_0011089 . obo:HP_0011091 obo:IAO_0000115 "The development of two teeth from a single tooth bud, leading to a larger fused tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:19:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:40273006", "UMLS:C0266033" ; oboInOwl:hasExactSynonym "Gemination of tooth", "Splitting of crown of tooth" ; oboInOwl:id "HP:0011091" ; a owl:Class ; rdfs:comment "If the fused tooth is counted singly, then the total number of teeth is normal with gemination. Usually, there is a larger dental crown with a single root and single canal." ; rdfs:label "Gemination" ; rdfs:subClassOf obo:HP_0011089 . obo:HP_0011092 obo:IAO_0000115 "Mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:25:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:109436001", "UMLS:C0266024" ; oboInOwl:hasNarrowSynonym "Syphilitic permanent first molar" ; oboInOwl:id "HP:0011092" ; a owl:Class ; rdfs:label "Mulberry molar" ; rdfs:subClassOf obo:HP_0011070, obo:HP_0033777 . obo:HP_0011093 obo:IAO_0000115 "Increased size and molar morphology of premolar tooth." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T02:32:39Z" ; oboInOwl:hasDbXref "UMLS:C1404304", "UMLS:C4280334" ; oboInOwl:hasExactSynonym "Molar shape of bicuspid", "Molar shape of premolar", "Molarization of bicuspid" ; oboInOwl:hasRelatedSynonym "Enlarged premolar", "Increased size of premolar" ; oboInOwl:id "HP:0011093" ; a owl:Class ; rdfs:label "Molarization of premolar" ; rdfs:subClassOf obo:HP_0011080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011094 obo:IAO_0000115 "Maxillary teeth cover the mandibular teeth when biting to an increased degree. The feature is defined as a vertical overlap of the maxillary incisors over the mandibular incisors that exceeds 2 mm." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T05:13:34Z" ; oboInOwl:hasDbXref "MSH:D057887", "SNOMEDCT_US:10816007", "SNOMEDCT_US:251293001", "SNOMEDCT_US:60476005", "SNOMEDCT_US:63783001", "UMLS:C0266063", "UMLS:C0266067", "UMLS:C1305740" ; oboInOwl:hasExactSynonym "Increased overlap of upper and lower incisors", "Overbite", "Supraocclusion" ; oboInOwl:hasNarrowSynonym "Deep bite", "Deep overbite", "Scissors bite" ; oboInOwl:id "HP:0011094" ; a owl:Class ; rdfs:label "Increased overbite" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0011095 obo:IAO_0000115 "An abnormal anteroposterior extension of the maxillary teeth beyond the plane of the mandibular teeth upon jaw closure." ; dcterms:creator ; oboInOwl:creation_date "2011-03-11T05:15:43Z" ; oboInOwl:hasDbXref "MSH:D057887", "SNOMEDCT_US:251292006", "SNOMEDCT_US:70305005", "UMLS:C0596028" ; oboInOwl:hasExactSynonym "Abnormality of horizontal incisor relationship", "Protrusion of upper teeth in front of lower teeth" ; oboInOwl:hasRelatedSynonym "Buck teeth", "Protrusion of the maxillary incisors", "Upper teeth sticking out forward" ; oboInOwl:id "HP:0011095" ; a owl:Class ; rdfs:label "Overjet" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0011096 obo:IAO_0000115 "A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." ; dcterms:creator ; oboInOwl:creation_date "2011-03-28T09:01:02Z" ; oboInOwl:hasAlternativeId "HP:0003381", "HP:0006939", "HP:0007282" ; oboInOwl:hasDbXref "UMLS:C0878575" ; oboInOwl:hasExactSynonym "Demyelination" ; oboInOwl:id "HP:0011096" ; a owl:Class ; rdfs:comment "This feature is generally diagnosed on the basis of a sural nerve biopsy. Demyelination is associated with slowed nerve conduction, increased refractoriness, and conduction block." ; rdfs:label "Peripheral demyelination" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011097 obo:IAO_0000115 "A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: Grimacing, head nodding, or subtle eye movements. Epileptic spasms frequently occur in clusters. Infantile spasms are the best known form, but spasms can occur at all ages" ; dcterms:creator ; oboInOwl:creation_date "2011-05-04T01:56:31Z" ; oboInOwl:hasDbXref "MSH:D013036", "SNOMEDCT_US:28055006", "UMLS:C0037769", "UMLS:C1527366" ; oboInOwl:hasExactSynonym "Epileptic spasms", "Salaam convulsion", "Salaam convulsions", "Salaam seizure", "Salaam seizures" ; oboInOwl:hasRelatedSynonym "West syndrome" ; oboInOwl:id "HP:0011097" ; a owl:Class ; rdfs:comment "The maximum age of onset is between 3 and 12 months, the peak being at 6 months. However, spasms may start from birth, or appear long after the age of 12 months, including into adulthood. Infantile spasms represent a specific type of seizure seen in an epilepsy syndrome of infancy and childhood known as West Syndrome. West Syndrome is characterized by infantile spasms, developmental regression, and hypsarrhythmia (as demonstrated by electroencephalography)." ; rdfs:label "Epileptic spasm" ; rdfs:subClassOf obo:HP_0020219 . obo:HP_0011098 obo:IAO_0000115 "A type of apraxia that is characterized by difficulty or inability to execute speech movements because of problems with coordination and motor problems, leading to incorrect articulation. An increase of errors with increasing word and phrase length may occur." ; dcterms:creator ; oboInOwl:creation_date "2011-05-15T08:57:11Z" ; oboInOwl:hasDbXref "MSH:D001072", "SNOMEDCT_US:361276003", "SNOMEDCT_US:361277007", "SNOMEDCT_US:74227009", "UMLS:C0264611", "UMLS:C0349391" ; oboInOwl:hasExactSynonym "Apraxia of speech", "Verbal dyspraxia" ; oboInOwl:hasRelatedSynonym "Speech dyspraxia" ; oboInOwl:id "HP:0011098" ; a owl:Class ; rdfs:comment "Speech apraxia may co-occur with oral apraxia and limb apraxia." ; rdfs:label "Speech apraxia" ; rdfs:subClassOf obo:HP_0002186 . obo:HP_0011099 obo:IAO_0000115 "Unilateral paresis (weakness) with spasticity of the affected muscles and increased tendon reflexes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-04T09:10:40Z" ; oboInOwl:hasDbXref "MSH:D006429", "SNOMEDCT_US:79633009", "UMLS:C0154694" ; oboInOwl:hasExactSynonym "Spastic hemiplegia" ; oboInOwl:id "HP:0011099" ; a owl:Class ; rdfs:label "Spastic hemiparesis" ; rdfs:subClassOf obo:HP_0001269, obo:HP_0034353, obo:HP_0100021 . obo:HP_0011100 obo:IAO_0000115 "An abnormal closure, or atresia of the tubular structure of the intestine." ; dcterms:creator ; oboInOwl:creation_date "2011-06-04T09:16:25Z" ; oboInOwl:hasDbXref "MSH:D007409", "UMLS:C0021828" ; oboInOwl:id "HP:0011100" ; a owl:Class ; rdfs:comment "Intestinal atresia is a broad term used to describe a complete blockage or obstruction anywhere in the intestine, in contrast to stenosis, which refers to a partial obstruction that results in a narrowing of the intestinal lumen." ; rdfs:label "Intestinal atresia" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0002589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011102 obo:IAO_0000115 "An abnormal closure, or atresia of the tubular structure of the ileum." ; dcterms:creator ; oboInOwl:creation_date "2011-06-04T09:22:34Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:25896009", "UMLS:C0266176" ; oboInOwl:id "HP:0011102" ; a owl:Class ; rdfs:label "Ileal atresia" ; rdfs:subClassOf obo:HP_0001549, obo:HP_0011100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011103 obo:IAO_0000115 "An abnormality of the outflow tract of the left ventricle." ; dcterms:creator ; oboInOwl:creation_date "2011-06-05T04:15:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253545000", "UMLS:C0344916" ; oboInOwl:hasExactSynonym "Abnormality of the left ventricular outflow tract" ; oboInOwl:id "HP:0011103" ; a owl:Class ; rdfs:label "Abnormal left ventricular outflow tract morphology" ; rdfs:subClassOf obo:HP_0001711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011104 obo:IAO_0000115 "An abnormality in the amount of volume occupied by intravascular blood." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:16:33Z" ; oboInOwl:hasDbXref "UMLS:C4023537" ; oboInOwl:id "HP:0011104" ; a owl:Class ; rdfs:label "Abnormality of blood volume homeostasis" ; rdfs:subClassOf obo:HP_0011028 . obo:HP_0011105 obo:IAO_0000115 "An increase in the amount of intravascular fluid, particularly in the volume of the circulating blood." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:17:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:21639008", "UMLS:C0546817" ; oboInOwl:hasExactSynonym "Fluid overload in blood" ; oboInOwl:id "HP:0011105" ; a owl:Class ; rdfs:label "Hypervolemia" ; rdfs:subClassOf obo:HP_0011104 . obo:HP_0011106 obo:IAO_0000115 "An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:18:54Z" ; oboInOwl:hasDbXref "MSH:D020896", "SNOMEDCT_US:28560003", "UMLS:C0546884" ; oboInOwl:hasExactSynonym "Depleted blood volume" ; oboInOwl:id "HP:0011106" ; a owl:Class ; rdfs:label "Hypovolemia" ; rdfs:subClassOf obo:HP_0011104 . obo:HP_0011107 obo:IAO_0000115 "Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T07:11:09Z" ; oboInOwl:hasDbXref "MSH:D013281", "SNOMEDCT_US:110426005", "SNOMEDCT_US:398870000", "SNOMEDCT_US:426965005", "SNOMEDCT_US:427617000", "UMLS:C0038363", "UMLS:C2937365" ; oboInOwl:hasExactSynonym "Recurrent canker sores", "Recurrent oral aphthae" ; oboInOwl:hasRelatedSynonym "Aphthous stomatitis", "Buccal aphthous ulcers", "Recurrent aphthous ulcers" ; oboInOwl:id "HP:0011107" ; a owl:Class ; rdfs:comment "Recurrent aphthous stomatitis can be classified into three forms, with minor ulcers (over 80% of RAS cases) being less than 1 cm in diameter and self-limiting; major ulcers being over 1 cm in diameter with potential scar formation; and herpetiform ulcers manifesting as recurrent episodes with multiple small ulcers throughout the oral mucosa." ; rdfs:label "Recurrent aphthous stomatitis" ; rdfs:subClassOf obo:HP_0010280, obo:HP_0032154 . obo:HP_0011108 obo:IAO_0000115 "A recurrent form of sinusitis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-10T07:31:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:195788001", "UMLS:C0581354", "UMLS:C4280333" ; oboInOwl:hasExactSynonym "Sinusitis, recurrent" ; oboInOwl:hasRelatedSynonym "Recurrent sinus disease" ; oboInOwl:id "HP:0011108" ; a owl:Class ; rdfs:comment "Recurring inflammation of the paranasal sinuses." ; rdfs:label "Recurrent sinusitis" ; rdfs:subClassOf obo:HP_0000246, obo:HP_0002788 . obo:HP_0011109 obo:IAO_0000115 "A chronic form of sinusitis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-10T07:33:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:40055000", "UMLS:C0149516", "UMLS:C0748720" ; oboInOwl:hasRelatedSynonym "Chronic sinus disease", "Sinusitis, chronic" ; oboInOwl:id "HP:0011109" ; a owl:Class ; rdfs:label "Chronic sinusitis" ; rdfs:subClassOf obo:HP_0000246 . obo:HP_0011110 obo:IAO_0000115 "Inflammation of the tonsils that has occurred repeatedly. The definition of recurrent may vary somewhat, but the criteria used recently as a measure of severity were five or more episodes of true tonsillitis per year, symptoms recurring for at least a year, and episodes that are disabling and that prevent normal functioning. In some cases recurrent tonsillitis may be related to immunosusceptibility. Evidence exists for a genetic predisposition for recurrent tonsillitis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-10T07:46:38Z" ; oboInOwl:hasDbXref "MSH:D014069", "SNOMEDCT_US:90176007", "UMLS:C0040425" ; oboInOwl:hasExactSynonym "Recurrent inflammation of tonsils" ; oboInOwl:id "HP:0011110" ; a owl:Class ; rdfs:label "Recurrent tonsillitis" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0100765 ; owl:equivalentClass _:genid80234 . obo:HP_0011111 obo:IAO_0000115 "An abnormality of the concentration or function of circulating immune proteins." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T08:58:47Z" ; oboInOwl:hasDbXref "UMLS:C4023536" ; oboInOwl:id "HP:0011111" ; a owl:Class ; rdfs:label "Abnormality of immune serum protein physiology" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0011112 obo:IAO_0000115 "Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:03:40Z" ; oboInOwl:hasDbXref "MP:0010210", "UMLS:C4023535" ; oboInOwl:id "HP:0011112" ; a owl:Class ; rdfs:label "Abnormality of serum cytokine level" ; rdfs:subClassOf obo:HP_0011111 . obo:HP_0011113 obo:IAO_0000115 "An abnormality in the production or cellular release of a cytokine (i.e., any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:07:24Z" ; oboInOwl:hasDbXref "MP:0003009", "UMLS:C4023534" ; oboInOwl:id "HP:0011113" ; a owl:Class ; rdfs:label "Abnormality of cytokine secretion" ; rdfs:subClassOf obo:HP_0011111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001816 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011114 obo:IAO_0000115 "An impairment in the production by leukocytes of NFKB1-dependent cytokines such as tumor necrosis factor-alpha and interferon-alpha." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:12:15Z" ; oboInOwl:hasDbXref "UMLS:C4023533" ; oboInOwl:id "HP:0011114" ; a owl:Class ; rdfs:label "Defective production of NFKB1-dependent cytokines" ; rdfs:subClassOf obo:HP_0011113 . obo:HP_0011115 obo:IAO_0000115 "An abnormality in the production or cellular release of a chemokine (a class of cytokines)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:14:25Z" ; oboInOwl:hasDbXref "UMLS:C4023532" ; oboInOwl:id "HP:0011115" ; a owl:Class ; rdfs:label "Abnormality of chemokine secretion" ; rdfs:subClassOf obo:HP_0011113 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0032602 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011116 obo:IAO_0000115 "An abnormality in the production or cellular release of interferons (a class of cytokines)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:14:43Z" ; oboInOwl:hasDbXref "UMLS:C4023531" ; oboInOwl:id "HP:0011116" ; a owl:Class ; rdfs:label "Abnormality of interferon secretion" ; rdfs:subClassOf obo:HP_0011113 . obo:HP_0011117 obo:IAO_0000115 "An abnormality in the production or cellular release of interleukins (a class of cytokines)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:16:10Z" ; oboInOwl:hasDbXref "UMLS:C4023530" ; oboInOwl:hasExactSynonym "Abnormality of IL secretion" ; oboInOwl:id "HP:0011117" ; a owl:Class ; rdfs:label "Abnormality of interleukin secretion" ; rdfs:subClassOf obo:HP_0011113 . obo:HP_0011118 obo:IAO_0000115 "An abnormality in the production or cellular release of tumor necrosis factor." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:16:58Z" ; oboInOwl:hasDbXref "MP:0008556", "UMLS:C4023529" ; oboInOwl:hasExactSynonym "Abnormality of cachectin secretion", "Abnormality of cachexin secretion", "Abnormality of tumour necrosis factor secretion" ; oboInOwl:id "HP:0011118" ; a owl:Class ; rdfs:label "Abnormality of tumor necrosis factor secretion" ; rdfs:subClassOf obo:HP_0011113 . obo:HP_0011119 obo:IAO_0000115 "An abnormality of the nasal dorsum, also known as the nasal ridge." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:37:47Z" ; oboInOwl:hasDbXref "UMLS:C4021202", "UMLS:C4280332" ; oboInOwl:hasExactSynonym "Abnormality of the dorsum of nose", "Abnormality of the nasal dorsum", "Abnormality of the nasal ridge", "Anomaly of the nasal ridge" ; oboInOwl:hasNarrowSynonym "Abnormal morphology of dorsum of nose", "Crooked dorsum of nose", "Crooked nasal dorsum", "Crooked nasal ridge", "Deformity of the dorsum of the nose", "Deformity of the nasal dorsum", "Deformity of the nasal ridge", "Malformation of the dorsum of nose", "Malformation of the nasal dorsum", "Malformation of the nasal ridge" ; oboInOwl:id "HP:0011119" ; a owl:Class ; rdfs:comment "The nasal ridge is the midline prominence of the nose, extending from the nasal root to the tip." ; rdfs:label "Abnormal nasal dorsum morphology" ; rdfs:subClassOf obo:HP_0010938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011120 obo:IAO_0000115 "Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T09:39:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:710234009", "UMLS:C0264169" ; oboInOwl:hasExactSynonym "Boxer's nasal deformity", "Boxer's nose deformity", "Concave dorsum of nose", "Concave nasal dorsum", "Saddle nose", "Saddle shaped nasal dorsum", "Ski jump nose" ; oboInOwl:hasRelatedSynonym "Saddle nose deformity" ; oboInOwl:id "HP:0011120" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A saddle-nose deformity can be congenital or acquired (e.g., traumatic) and is associated with structural compromise of the nasoseptal cartilage leading to decreased dorsal nasal structural support. A depression of the dorsum of the nose with loss of nasal tip support and definition, shortened (vertical) nasal length, overrotation of the nasal tip, and retrusion of the nasal spine and caudal septum." ; rdfs:label "Concave nasal ridge" ; rdfs:subClassOf obo:HP_0011119 . obo:HP_0011121 obo:IAO_0000115 "Any morphological abnormality of the skin." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T10:03:23Z" ; oboInOwl:hasDbXref "Fyler:4133", "UMLS:C4023528" ; oboInOwl:hasExactSynonym "Abnormal skin morphology", "Abnormal skin structure" ; oboInOwl:id "HP:0011121" ; a owl:Class ; rdfs:label "Abnormality of skin morphology" ; rdfs:subClassOf obo:HP_0000951 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011122 obo:IAO_0000115 "Any abnormality of the physiological function of the skin." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T10:05:14Z" ; oboInOwl:hasDbXref "UMLS:C4023527" ; oboInOwl:hasExactSynonym "Abnormality of skin physiology" ; oboInOwl:id "HP:0011122" ; a owl:Class ; rdfs:label "Abnormality of skin physiology" ; rdfs:subClassOf obo:HP_0000951 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011123 obo:IAO_0000115 "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T10:06:04Z" ; oboInOwl:hasAlternativeId "HP:0002727", "HP:0007423" ; oboInOwl:hasDbXref "MP:0004947", "MSH:D003872", "SNOMEDCT_US:703938007", "UMLS:C0011603", "UMLS:C3875321" ; oboInOwl:hasExactSynonym "Abnormal tendency to infections of the skin", "Inflammatory abnormality of the skin", "Skin inflammation" ; oboInOwl:hasRelatedSynonym "Dermatitis", "Inflammatory skin disease" ; oboInOwl:id "HP:0011123" ; a owl:Class ; rdfs:label "Inflammatory abnormality of the skin" ; rdfs:subClassOf obo:HP_0011122, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011124 obo:IAO_0000115 "An abnormality of the morphology of the epidermis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T10:11:28Z" ; oboInOwl:hasDbXref "UMLS:C4023526" ; oboInOwl:hasExactSynonym "Abnormality of epidermal morphology" ; oboInOwl:id "HP:0011124" ; a owl:Class ; rdfs:label "Abnormal epidermal morphology" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011125 obo:IAO_0000115 "An abnormality of the melanosomes, i.e., of the cellular organelles in which melanin pigments are synthesized and stored within melanocytes (the cells that produce pigment in the dermis)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-12T10:19:27Z" ; oboInOwl:hasDbXref "UMLS:C4023525" ; oboInOwl:id "HP:0011125" ; a owl:Class ; rdfs:label "Abnormality of dermal melanosomes" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0011126 obo:IAO_0000115 "A significant descent of the kidney as the patient moves from the supine to the erect position." ; dcterms:creator ; oboInOwl:creation_date "2011-06-16T07:34:25Z" ; oboInOwl:hasDbXref "UMLS:C1384594" ; oboInOwl:hasExactSynonym "Floating kidney", "Renal ptosis" ; oboInOwl:id "HP:0011126" ; a owl:Class ; rdfs:comment "Nephroptosis is diagnosed if the descent of the kidney is greater than 5 cm or two vertebral bodies on intravenous urogram. The kidney is capable of moving back to the normal position, which differentiates it from an ectopic kidney, which constantly remains in an abnormal position. Nephroptosis may be asymptomatic or may cause symptoms including pain and intermittent ureteric obstruction with hydronephrosis, and ischemia due to elongation, narrowing, or kinking of a renal artery." ; rdfs:label "Nephroptosis" ; rdfs:subClassOf obo:HP_0100542 . obo:HP_0011127 obo:IAO_0000115 "A type of eczema that occurs in the lips and perioral area." ; dcterms:creator ; oboInOwl:creation_date "2011-06-16T07:41:19Z" ; oboInOwl:hasDbXref "UMLS:C1396126" ; oboInOwl:hasExactSynonym "Eczema around the mouth" ; oboInOwl:id "HP:0011127" ; a owl:Class ; rdfs:comment "Perioral eczema mainly affects children." ; rdfs:label "Perioral eczema" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0011128 obo:IAO_0000115 "A condition characterized by necrosis of the mucosal and submucosal layers of the esophagus not related to ingestion of caustic or other injurious agents. Endoscopically, there is a dark lesion ('black esophagus') distributed in a circumferential manner in the distal one-third of the esophagus with or without exudates. There is involvement of the distal esophagus ending sharply at the gastroesophageal junction." ; dcterms:creator ; oboInOwl:creation_date "2011-06-18T08:48:53Z" ; oboInOwl:hasDbXref "UMLS:C4023524" ; oboInOwl:id "HP:0011128" ; a owl:Class ; rdfs:label "Acute esophageal necrosis" ; rdfs:subClassOf obo:HP_0002031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011129 obo:IAO_0000115 "A bilateral form of fetal pyelectasis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T10:00:34Z" ; oboInOwl:hasDbXref "UMLS:C4023523" ; oboInOwl:hasExactSynonym "Bilateral fetal pyelectasia", "Bilateral foetal pyelectasia", "Bilateral foetal pyelectasis" ; oboInOwl:id "HP:0011129" ; a owl:Class ; rdfs:label "Bilateral fetal pyelectasis" ; rdfs:subClassOf obo:HP_0010945 . obo:HP_0011130 obo:IAO_0000115 "Any abnormality of the morphology of the major calices or minor calices of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T10:06:45Z" ; oboInOwl:hasDbXref "UMLS:C4023522" ; oboInOwl:hasExactSynonym "Abnormality of renal calyx morphology" ; oboInOwl:id "HP:0011130" ; a owl:Class ; rdfs:label "Abnormal renal calyx morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011131 obo:IAO_0000115 "The presence of a rash (change of color and texture) of the perianal skin." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T12:16:41Z" ; oboInOwl:hasDbXref "UMLS:C0240705" ; oboInOwl:hasExactSynonym "Perianal rash" ; oboInOwl:id "HP:0011131" ; a owl:Class ; rdfs:label "Perianal dermatitis" ; rdfs:subClassOf obo:HP_0034915 . obo:HP_0011132 obo:IAO_0000115 "A furuncle (boil) is a skin infection involving an entire hair follicle and nearby skin tissue. Chronic furunculosis refers to recurrent episodes of furuncles, often caused by recurrent staphylococcus infection." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T10:25:47Z" ; oboInOwl:hasDbXref "UMLS:C4023521" ; oboInOwl:id "HP:0011132" ; a owl:Class ; rdfs:comment "Note that a confluence of several furuncles results in a carbuncle." ; rdfs:label "Chronic furunculosis" ; rdfs:subClassOf obo:HP_0005406 . obo:HP_0011133 obo:IAO_0000115 "An abnormally increased sensitivity to the effects of ionizing radiation." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T11:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4021850" ; oboInOwl:hasExactSynonym "Increased sensitivity to ionising radiation" ; oboInOwl:id "HP:0011133" ; a owl:Class ; rdfs:comment "Ionizing radiation can lead to the production of free radicals, break chemical bonds, and damage DNA; RNA, and proteins. Cellular damage related to low doses such as that received from normal background radiation is rapidly repaired under normal conditions." ; rdfs:label "Increased sensitivity to ionizing radiation" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0011134 obo:IAO_0000115 "Mild fever that does not exceed 38.5 degrees centigrade." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T12:19:44Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:304213008", "UMLS:C0239574" ; oboInOwl:hasExactSynonym "Low-grade fever", "Mild fever" ; oboInOwl:id "HP:0011134" ; a owl:Class ; rdfs:label "Low-grade fever" ; rdfs:subClassOf obo:HP_0001945 . obo:HP_0011135 obo:IAO_0000115 "Absence or developmental hypoplasia of the sweat glands." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T02:01:50Z" ; oboInOwl:hasDbXref "UMLS:C4023520" ; oboInOwl:hasExactSynonym "Absent/small sweat glands", "Absent/underdeveloped sweat glands" ; oboInOwl:id "HP:0011135" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the sweat glands" ; rdfs:subClassOf obo:HP_0000971 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011136 obo:IAO_0000115 "Absence of the sweat glands." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T02:06:44Z" ; oboInOwl:hasDbXref "UMLS:C2677485" ; oboInOwl:hasExactSynonym "Absent sweat glands", "Lack of sweat glands" ; oboInOwl:id "HP:0011136" ; a owl:Class ; rdfs:label "Aplasia of the sweat glands" ; rdfs:subClassOf obo:HP_0011135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001820 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011137 obo:IAO_0000115 "Pale reddish slightly elevated papules and plaques of 0.5-3 cm in diameter and not accompanied by pruritus." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T02:17:55Z" ; oboInOwl:hasDbXref "UMLS:C4023519" ; oboInOwl:hasExactSynonym "Non-itchy hives" ; oboInOwl:id "HP:0011137" ; a owl:Class ; rdfs:comment "Although the English-language names for uritcaria and non-pruritic urticaria are very similar these are treated as distinct lesions. Non-pruritic urticaria should not be considered to be a subclass of urticaria, because the latter is characterized by pruritus." ; rdfs:label "Non-pruritic urticaria" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0011138 obo:IAO_0000115 "An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands." ; dcterms:creator ; oboInOwl:creation_date "2011-06-19T06:25:34Z" ; oboInOwl:hasDbXref "UMLS:C4023518" ; oboInOwl:hasExactSynonym "Abnormal skin appendage" ; oboInOwl:id "HP:0011138" ; a owl:Class ; rdfs:label "Abnormality of skin adnexa morphology" ; rdfs:subClassOf obo:HP_0001574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011139 obo:IAO_0000115 "Gastric duplication is a usually cystic malformation of gastrointestinal tract, usually attached to the greater curvature of the stomach and has no communication with the stomach." ; dcterms:creator ; oboInOwl:creation_date "2011-06-25T08:57:09Z" ; oboInOwl:hasDbXref "UMLS:C4021201" ; oboInOwl:hasExactSynonym "Gastric duplication cyst" ; oboInOwl:id "HP:0011139" ; a owl:Class ; rdfs:comment "Gastric duplication usually presents as gastric outlet obstruction. They are usually spherical in form, do not communicate with the stomach, and are generally localized at the greater curvature. In some cases they may exhibit adhesion to the pancreas and even communicate with aberrant pancreatic ducts. Gastric duplication is more frequent in females. It is generally either diagnosed in infancy because of symptoms of gastric outlet obstruction or is an incidental finding in adulthood." ; rdfs:label "Gastric duplication" ; rdfs:subClassOf obo:HP_0002577, obo:HP_0011140 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000945 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011140 obo:IAO_0000115 "A spherical hollow structure with a smooth muscle coat, lined by a mucous membrane, and attached to any part of the gastrointestinal tract, from the base of the tongue to the anus." ; dcterms:creator ; oboInOwl:creation_date "2011-06-25T09:02:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:33257003", "UMLS:C0266019" ; oboInOwl:hasExactSynonym "GI duplication" ; oboInOwl:id "HP:0011140" ; a owl:Class ; rdfs:label "Gastrointestinal duplication" ; rdfs:subClassOf obo:HP_0012718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011141 obo:IAO_0000115 "A type of cataract (opacification of the lens) that forms during the course of aging." ; dcterms:creator ; oboInOwl:creation_date "2011-06-27T09:41:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:39450006", "UMLS:C0036646" ; oboInOwl:hasExactSynonym "Clouding of the lens of the eye with age" ; oboInOwl:id "HP:0011141" ; a owl:Class ; rdfs:comment "The lens is formed from ectodermal tissue and contains epithelial cells that give rise to lens fibres throughout life, so with increasing age the lens becomes more compact and thicker." ; rdfs:label "Age-related cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0011142 obo:IAO_0000115 "A type of age-related cataract that primarily affects the nucleus of the lens." ; dcterms:creator ; oboInOwl:creation_date "2011-06-27T09:49:20Z" ; oboInOwl:hasDbXref "MSH:C563333", "UMLS:C1832423" ; oboInOwl:id "HP:0011142" ; a owl:Class ; rdfs:comment "As the lens ages, new layers of fibres are added and the lens nucleus is compressed and becomes harder (nuclear sclerosis cataract), with associated yellowing of the lens. Nuclear sclerosis typically progresses slowly." ; rdfs:label "Age-related nuclear cataract" ; rdfs:subClassOf obo:HP_0011141 . obo:HP_0011143 obo:IAO_0000115 "A type of age-related cataract that primarily affects the cortex of the lens." ; dcterms:creator ; oboInOwl:creation_date "2011-06-27T09:50:54Z" ; oboInOwl:hasDbXref "UMLS:C2880562" ; oboInOwl:id "HP:0011143" ; a owl:Class ; rdfs:comment "The cortex of the lens is made of the newest lens fibres. With ageing, discrete opacities can develop within the cortex of the lens that typically cause no visual symptoms unless they involve the visual axis or the entire cortex, in which case the lens becomes white and is said to be mature." ; rdfs:label "Age-related cortical cataract" ; rdfs:subClassOf obo:HP_0011141 . obo:HP_0011144 obo:IAO_0000115 "A type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule." ; dcterms:creator ; oboInOwl:creation_date "2011-06-27T09:52:45Z" ; oboInOwl:hasDbXref "UMLS:C4023517" ; oboInOwl:id "HP:0011144" ; a owl:Class ; rdfs:label "Age-related posterior subcapsular cataract" ; rdfs:subClassOf obo:HP_0011141 . obo:HP_0011145 obo:IAO_0000115 "A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T01:40:33Z" ; oboInOwl:hasDbXref "UMLS:C4023516" ; oboInOwl:id "HP:0011145" ; a owl:Class ; rdfs:comment """While all patients with epilepsy experience seizures, not all individuals with seizures have epilepsy. One or more epileptic seizures may occur in the context of a brain insult (systemic, toxic, or metabolic). These events (defined acute symptomatic seizures, provoked seizures, or situation-related seizures) are presumed to be an acute manifestation of the insult and may not recur when the underlying cause has been removed or the acute phase has elapsed.""" ; rdfs:label "Symptomatic seizures" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0011146 obo:IAO_0000115 "A dialeptic seizure is a type of seizure characterised predominantly by reduced responsiveness or awareness and with subsequent at least partial amnesia of the event." ; oboInOwl:creation_date "2011-10-18T01:47:30Z" ; oboInOwl:hasExactSynonym "Behavioral arrest seizure with impairment of awareness irrespective of onset", "Behavioural arrest seizure with impairment of awareness irrespective of onset", "Unknown onset behavioral arrest seizure with impairment of awareness", "Unknown onset behavioural arrest seizure with impairment of awareness" ; oboInOwl:id "HP:0011146" ; a owl:Class ; rdfs:comment "The main ictal manifestation of dialeptic seizures is an alteration of consciousness rather than motor or sensory features. The term describes the pure clinical semiology of a seizure and is used independently of the ictal electrographic findings: it could describe a seizure of focal, generalized or unknown onset. In 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (>80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination." ; rdfs:label "Dialeptic seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0011147 obo:IAO_0000115 "A typical absence seizure is a type of generalised non-motor (absence) seizure characterised by its sudden onset, interruption of ongoing activities, a blank stare, possibly a brief upward deviation of the eyes. Usually the patient will be unresponsive when spoken to. Duration is a few seconds to half a minute with very rapid recovery. Although not always available, an EEG would usually show 3 Hz generalized epileptiform discharges during the event." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T01:52:22Z" ; oboInOwl:hasDbXref "MSH:D004832", "SNOMEDCT_US:230413002", "SNOMEDCT_US:432241000124101", "SNOMEDCT_US:50866000", "SNOMEDCT_US:79631006", "UMLS:C0014553" ; oboInOwl:hasExactSynonym "Typical absence", "Typical absence seizures" ; oboInOwl:id "HP:0011147" ; a owl:Class ; rdfs:comment "In 2017 the ILAE Commission for Classification and Terminology recommended classifying a seizure as having focal or generalized onset only when there is a high degree of confidence (>80%, arbitrarily chosen to parallel the usual allowable beta error) in the accuracy of this determination; see Dialeptic seizure. Typical absences have 2 essential components: (1) clinically the impairment of consciousness (absence), and (2) EEG generalized 3 Hz to 4 Hz (less than 2.5 Hz) spike and slow wave discharges." ; rdfs:label "Typical absence seizure" ; rdfs:subClassOf obo:HP_0002121 . obo:HP_0011148 obo:IAO_0100001 "HP:0002121" ; oboInOwl:creation_date "2011-10-18T01:56:54Z" ; oboInOwl:id "HP:0011148" ; a owl:Class ; rdfs:label "obsolete Absence seizures with special features" ; owl:deprecated true . obo:HP_0011149 obo:IAO_0000115 "An absence with eyelid myoclonia seizure is a type of generalized non-motor (absence) seizure characterised by forced upward jerking of the eyelids during an absence seizure." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:03:21Z" ; oboInOwl:hasDbXref "UMLS:C4023513" ; oboInOwl:hasExactSynonym "Absence seizures with eyelid myoclonia" ; oboInOwl:id "HP:0011149" ; a owl:Class ; rdfs:comment "This type of seizure was classified as a type of generalized non-motor seizure by the ILAE in 2017 because the absence predominates over the eyelid myoclonia. However, eyelid myoclonia can occur as a generalized-onset seizure without any absence, in which they may be better considered a motor seizure: see Eyelid myoclonia seizure." ; rdfs:label "Absence seizure with eyelid myoclonia" ; rdfs:subClassOf obo:HP_0002121, obo:HP_0032678 . obo:HP_0011150 obo:IAO_0000115 "Myoclonic absence seizure is a type of generalized non-motor (absence) seizure characterised by an interruption of ongoing activities, a blank stare and rhythmic three-per-second myoclonic movements, causing ratcheting abduction of the upper limbs leading to progressive arm elevation, and associated with 3 Hz generalized spike-wave discharges on the electroencephalogram. Duration is typically 10-60 s. Whilst impairment of consciousness may not be obvious the ILAE classified this seizure as a generalized non-motor seizure in 2017." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:04:35Z" ; oboInOwl:hasDbXref "UMLS:C4023512" ; oboInOwl:hasExactSynonym "Myoclonic absence", "Myoclonic absences" ; oboInOwl:id "HP:0011150" ; a owl:Class ; rdfs:label "Myoclonic absence seizure" ; rdfs:subClassOf obo:HP_0002121 . obo:HP_0011151 obo:IAO_0000115 "Atypical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged atypical absence seizure." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:09:55Z" ; oboInOwl:hasDbXref "UMLS:C4023511" ; oboInOwl:hasExactSynonym "Obtundation status" ; oboInOwl:id "HP:0011151" ; a owl:Class ; rdfs:comment "In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity. This form of seizure may be observed in Lennox-Gastaut syndrome." ; rdfs:label "Atypical absence status epilepticus" ; rdfs:subClassOf obo:HP_0031475, obo:HP_0032860 . obo:HP_0011152 obo:IAO_0000115 "Typical absence seizures starting before the age of 4 years." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:12:41Z" ; oboInOwl:hasDbXref "UMLS:C4023510" ; oboInOwl:hasExactSynonym "Early onset petit mal seizures" ; oboInOwl:id "HP:0011152" ; a owl:Class ; rdfs:label "Early onset absence seizures" ; rdfs:subClassOf obo:HP_0011147 . obo:HP_0011153 obo:IAO_0000115 "A type of focal-onset seizure characterized by a motor sign as its initial semiological manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:33:17Z" ; oboInOwl:hasDbXref "MSH:D020938", "SNOMEDCT_US:128612007", "SNOMEDCT_US:82401000", "UMLS:C0016399" ; oboInOwl:hasExactSynonym "Focal motor seizures", "Localised motor seizure", "Localised motor seizures", "Localized motor seizure", "Localized motor seizures", "Partial motor seizure", "Partial motor seizures", "Segmental motor seizure" ; oboInOwl:id "HP:0011153" ; a owl:Class ; rdfs:comment "A motor onset seizure involves motor activity (movement) and may be due to either an increase or decrease in contraction in a muscle or group of muscles. Depending on the muscle groups involved and the way they are affected, the movement features of a motor onset seizure may be simple or more complex." ; rdfs:label "Focal motor seizure" ; rdfs:subClassOf obo:HP_0007359, obo:HP_0020219 . obo:HP_0011154 obo:IAO_0000115 "An autonomic seizure is a type of focal non-motor seizure characterized by alteration of autonomic nervous system function as the initial semiological feature." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:23:31Z" ; oboInOwl:hasAlternativeId "HP:0011164" ; oboInOwl:hasDbXref "UMLS:C4023509" ; oboInOwl:hasExactSynonym "Focal autonomic seizures" ; oboInOwl:id "HP:0011154" ; a owl:Class ; rdfs:comment "Focal seizures with a subjective or objectively documented alteration of autonomic nervous system function at onset, involving but not limited to, cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor and thermoregulatory functions. Focal autonomic seizure is not a child of Epileptic aura (HP:0033348) as many Focal autonomic seizures are not purely subjective (required to be called an aura)." ; rdfs:label "Focal autonomic seizure" ; rdfs:subClassOf obo:HP_0032679 . obo:HP_0011155 obo:IAO_0100001 "HP:0032755" ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:24:09Z" ; oboInOwl:id "HP:0011155" ; a owl:Class ; rdfs:label "obsolete Focal autonomic seizures with altered responsiveness" ; owl:deprecated true . obo:HP_0011156 obo:IAO_0100001 "HP:0032740" ; oboInOwl:creation_date "2011-10-18T02:24:42Z" ; oboInOwl:id "HP:0011156" ; a owl:Class ; rdfs:label "obsolete Focal autonomic seizures without altered responsiveness" ; owl:deprecated true . obo:HP_0011157 obo:IAO_0000115 "A focal sensory seizure is a type seizure beginning with a subjective sensation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:26:40Z" ; oboInOwl:hasDbXref "MSH:D004827", "SNOMEDCT_US:18618006", "UMLS:C0236018" ; oboInOwl:hasExactSynonym "Focal sensory seizures", "Partial sensory seizure", "Sensory aura" ; oboInOwl:id "HP:0011157" ; a owl:Class ; rdfs:comment "A focal sensory seizure involves a sensation being experienced at seizure onset, without objective clinical signs of a seizure evident to the observer." ; rdfs:label "Focal sensory seizure" ; rdfs:subClassOf obo:HP_0032679, obo:HP_0033348 . obo:HP_0011158 obo:IAO_0000115 "A seizure characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones as its first clinical manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:26:59Z" ; oboInOwl:hasDbXref "UMLS:C1838063" ; oboInOwl:hasExactSynonym "Auditory aura", "Focal auditory seizure", "Focal sensory auditory seizure", "Partial auditory seizure" ; oboInOwl:id "HP:0011158" ; a owl:Class ; rdfs:comment "More complex auditory hallucinations such as voices are considered a focal cognitive seizure. Focal sensory auditory seizures involve auditory cortex in the lateral superior temporal lobe." ; rdfs:label "Focal sensory seizure with auditory features" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0011159 obo:IAO_0000115 "A type of focal autonomic seizure characterised by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:27:58Z" ; oboInOwl:hasDbXref "UMLS:C4023506" ; oboInOwl:hasExactSynonym "Abdominal aura", "Epigastric aura", "Epigastric auras", "Localised seizure with epigastric sensation", "Localized seizure with epigastric sensation", "Partial seizure with epigastric sensation", "Visceral aura" ; oboInOwl:id "HP:0011159" ; a owl:Class ; rdfs:comment "This includes epigastric sensations (which may rise up to the chest or throat) such as upper abdominal discomfort, emptiness, tightness, churning, or hunger, as well as ictal nausea and ictal vomiting." ; rdfs:label "Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0011160 obo:IAO_0000115 "A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes as its first clinical manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:28:36Z" ; oboInOwl:hasDbXref "MSH:D006212", "SNOMEDCT_US:29139005", "UMLS:C0233766" ; oboInOwl:hasExactSynonym "Focal gustatory seizure", "Focal sensory gustatory seizure", "Gustatory aura", "Gustatory auras", "Partial gustatory seizure", "Taste hallucinations" ; oboInOwl:id "HP:0011160" ; a owl:Class ; rdfs:comment "These seizures involve the parietal operculum and the insula." ; rdfs:label "Focal sensory seizure with gustatory features" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0011161 obo:IAO_0000115 "Seizures characterized by olfactory phenomena as its first clinical manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:28:55Z" ; oboInOwl:hasDbXref "UMLS:C4023504" ; oboInOwl:hasExactSynonym "Focal olfactory seizure", "Olfactory aura", "Olfactory auras", "Partial olfactory seizure" ; oboInOwl:id "HP:0011161" ; a owl:Class ; rdfs:comment "These seizures involve the mesial temporal or orbitofrontal regions." ; rdfs:label "Focal sensory seizure with olfactory features" ; rdfs:subClassOf obo:HP_0011157, obo:HP_0033693 . obo:HP_0011162 obo:IAO_0100001 "HP:0032680" ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:29:23Z" ; oboInOwl:id "HP:0011162" ; a owl:Class ; rdfs:label "obsolete Psychic auras" ; owl:deprecated true . obo:HP_0011163 obo:IAO_0000115 "A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move as its first clinical manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:29:52Z" ; oboInOwl:hasDbXref "UMLS:C4023502" ; oboInOwl:hasExactSynonym "Focal somatosensory seizure", "Partial somatosensory seizure", "Somatosensory aura", "Somatosensory auras" ; oboInOwl:id "HP:0011163" ; a owl:Class ; rdfs:comment "These seizures involve the sensorimotor cortex." ; rdfs:label "Focal sensory seizure with somatosensory features" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0011164 obo:IAO_0100001 "HP:0011154" ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:30:10Z" ; oboInOwl:id "HP:0011164" ; a owl:Class ; rdfs:label "obsolete Vegetative auras" ; owl:deprecated true . obo:HP_0011165 obo:IAO_0000115 "A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis as its first clinical manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:31:15Z" ; oboInOwl:hasAlternativeId "HP:0007175", "HP:0025121" ; oboInOwl:hasDbXref "UMLS:C1850765" ; oboInOwl:hasExactSynonym "Focal visual seizure", "Partial visual seizure", "Visual aura", "Visual auras" ; oboInOwl:hasRelatedSynonym "Simple partial occipital seizures" ; oboInOwl:id "HP:0011165" ; a owl:Class ; rdfs:comment "More complex visual hallucinations such as seeing formed images are considered a focal cognitive seizure. Focal sensory visual seizures arise in the occipital lobe. Note that there is a distinction between Visual aura and Simple partial occipital seizures. See HPO term HP:0025121 for comments." ; rdfs:label "Focal sensory seizure with visual features" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0011166 obo:IAO_0000115 "A type of focal motor seizure characterized by sudden, brief (<100 ms) involuntary single or multiple contraction(s) of muscles(s) or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:34:14Z" ; oboInOwl:hasAlternativeId "HP:0025191" ; oboInOwl:hasDbXref "UMLS:C4023501" ; oboInOwl:hasExactSynonym "Focal myoclonic seizures", "Local myoclonic seizures", "Localised myoclonic seizure", "Localized myoclonic seizure", "Partial myoclonic seizure", "Partial myoclonic seizures", "Segmental myoclonic seizure", "Segmental myoclonic seizures" ; oboInOwl:id "HP:0011166" ; a owl:Class ; rdfs:label "Focal myoclonic seizure" ; rdfs:subClassOf obo:HP_0011153, obo:HP_0032794 . obo:HP_0011167 obo:IAO_0000115 "A type of focal motor seizure characterized by sustained increase in muscle contraction, lasting a few seconds to minutes." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:35:03Z" ; oboInOwl:hasDbXref "MSH:D020938", "UMLS:C0752324" ; oboInOwl:hasExactSynonym "Focal tonic seizures", "Local tonic seizures", "Localised tonic seizure", "Localized tonic seizure", "Partial tonic seizure", "Partial tonic seizures", "Segmental tonic seizure" ; oboInOwl:id "HP:0011167" ; a owl:Class ; rdfs:comment "The abnormal movements of dystonia resulting from co-contraction of agonist and antagonist muscles differentiates these from tonic seizures, see focal dystonic seizure." ; rdfs:label "Focal tonic seizure" ; rdfs:subClassOf obo:HP_0011153, obo:HP_0032792 . obo:HP_0011168 obo:IAO_0000115 "Focal seizure with eyelid myoclonia, not eyelid myoclonias in the context of absence seizures." ; dcterms:creator ; oboInOwl:creation_date "2011-10-18T02:39:07Z" ; oboInOwl:hasDbXref "UMLS:C4023500" ; oboInOwl:hasExactSynonym "Eyelid myoclonias" ; oboInOwl:id "HP:0011168" ; a owl:Class ; rdfs:label "Focal seizure with eyelid myoclonia" ; rdfs:subClassOf obo:HP_0011166 . obo:HP_0011169 obo:IAO_0000115 "Generalized clonic seizure is a type of generalized motor seizure characterised by sustained bilateral jerking, either symmetric or asymmetric, that is regularly repetitive and involves the same muscle groups." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T09:53:43Z" ; oboInOwl:hasDbXref "UMLS:C4023499" ; oboInOwl:hasExactSynonym "Generalised clonic seizure", "Generalised clonic seizures", "Generalised onset clonic seizure", "Generalised-onset clonic seizure", "Generalized clonic seizures", "Generalized onset clonic seizure", "Generalized-onset clonic seizure" ; oboInOwl:id "HP:0011169" ; a owl:Class ; rdfs:comment "Generalized clonic seizures are much less common than are tonic-clonic seizures, usually occur in infants, and should be distinguished from jitteriness or shuddering attacks." ; rdfs:label "Generalized clonic seizure" ; rdfs:subClassOf obo:HP_0020221, obo:HP_0032677 . obo:HP_0011170 obo:IAO_0000115 "A generalized myoclonic-atonic seizure is a type of generalized motor seizure characterized by a myoclonic jerk followed by an atonic motor component." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:00:46Z" ; oboInOwl:hasDbXref "MSH:D004831", "SNOMEDCT_US:230421008", "UMLS:C0393702" ; oboInOwl:hasExactSynonym "Generalised myoclonic-atonic seizure", "Myoclonic atonic seizures", "Myoclonic-astatic seizure" ; oboInOwl:id "HP:0011170" ; a owl:Class ; rdfs:comment "A myoclonic-tonic seizure was previously called a myoclonic-astatic seizure. ILAE2017 does not currently consider myoclonic-atonic seizures to be a form of myoclonic seizure which is why it is classified as a motor seizure." ; rdfs:label "Generalized myoclonic-atonic seizure" ; rdfs:subClassOf obo:HP_0032677 . obo:HP_0011171 obo:IAO_0000115 "A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:09:04Z" ; oboInOwl:hasDbXref "MSH:D003294", "SNOMEDCT_US:432354000", "UMLS:C0149886" ; oboInOwl:hasExactSynonym "Simple febrile convulsion", "Simple febrile seizures", "Simple fever fit" ; oboInOwl:id "HP:0011171" ; a owl:Class ; rdfs:comment "Fever may not be detected before the seizure, but it must be present at least in the immediate postacute period. In most cases these seizures are of a generalized tonic-clonic semiology." ; rdfs:label "Simple febrile seizure" ; rdfs:subClassOf obo:HP_0002373 . obo:HP_0011172 obo:IAO_0000115 "A febrile seizure that has any of the following features: focal semiology (or associated with post-ictal neurologic abnormalities beyond drowsiness, such as a Todd's paresis), prolonged seizure beyond 15 minutes, or recurring (occurring more than once) in a 24 hour period." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:10:00Z" ; oboInOwl:hasDbXref "MSH:D003294", "SNOMEDCT_US:433083002", "UMLS:C0751057" ; oboInOwl:hasExactSynonym "Complex febrile convulsion", "Complex febrile seizures", "Complex fever fit" ; oboInOwl:id "HP:0011172" ; a owl:Class ; rdfs:comment "Children presenting with a prolonged seizure stopped with anticonvulsive therapy (i.e., diazepam) before the 15th minute should be classified within this group." ; rdfs:label "Complex febrile seizure" ; rdfs:subClassOf obo:HP_0002373 . obo:HP_0011173 obo:IAO_0000115 "A type of focal non-motor seizure characterized by an arrest or pause of activities, freezing, or immobilization as the predominant semiological feature throughout the seizure." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:12:04Z" ; oboInOwl:hasDbXref "UMLS:C4023498" ; oboInOwl:hasExactSynonym "Focal behaviour arrest seizure", "Focal hypokinetic seizure", "Hypokinetic seizure", "Hypokinetic seizures", "Localised seizure with behavioural arrest", "Localized seizure with behavioral arrest", "Partial hypokinetic seizure", "Partial seizure with behavior arrest", "Partial seizure with behaviour arrest" ; oboInOwl:id "HP:0011173" ; a owl:Class ; rdfs:comment "The word 'focal' is explicit in the term title to emphasise the difference between these seizures and absence (generalised non-motor) seizures. Because brief behavior arrest is common and difficult to identify at the start of many seizures, the arrest must be persistent and dominant through the entire seizure. If the patient is able to identify that fear is the primary onset feature of the seizure, and results in immobility, the seizure is a focal emotional seizure with fear, and the immobility is then considered a descriptive feature, due to the fear. If the focal seizure is not characterized by this feature at the very outset of the seizure, it is not used to classify the seizure, it is instead used as a seizure descriptor, after the seizure is classified according to its onset feature." ; rdfs:label "Focal behavior arrest seizure" ; rdfs:subClassOf obo:HP_0032679 . obo:HP_0011174 obo:IAO_0000115 "A focal seizure characterized at onset by predominantly proximal limb or axial muscles producing irregular sequential ballistic movements, such as pedaling, pelvic thrusting, thrashing, rocking movements." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:13:17Z" ; oboInOwl:hasDbXref "UMLS:C4023497" ; oboInOwl:hasExactSynonym "Hyperkinetic seizures", "Localised hyperkinetic seizure", "Localized hyperkinetic seizure", "Partial hyperkinetic seizure", "Segmental hyperkinetic seizure" ; oboInOwl:id "HP:0011174" ; a owl:Class ; rdfs:comment "The 2017 ILAE classification arbitrarily groups pedaling activity with hyperkinetic seizures, rather than with automatism seizures. However, some automatisms overlap other motor behaviors and where pedaling is slow and coordinated it may be considered an automatism." ; rdfs:label "Focal hyperkinetic seizure" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0011175 obo:IAO_0000115 "A type of focal motor seizure characterised by sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral deviation from the midline as the initial semiological manifestation." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:14:54Z" ; oboInOwl:hasDbXref "MSH:D020938", "SNOMEDCT_US:246530009", "UMLS:C0422846" ; oboInOwl:hasExactSynonym "Versive seizure", "Versive seizures" ; oboInOwl:id "HP:0011175" ; a owl:Class ; rdfs:label "Focal motor seizure with version" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0011176 obo:IAO_0000115 "An EEG with constitutional variants contains waves that are rare or unusual but not generally pathologic." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:18:43Z" ; oboInOwl:hasDbXref "UMLS:C4023496" ; oboInOwl:id "HP:0011176" ; a owl:Class ; rdfs:label "EEG with constitutional variants" ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0011177 obo:IAO_0000115 "EEG background activity at 4-5/second." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:20:59Z" ; oboInOwl:hasDbXref "UMLS:C4023495" ; oboInOwl:id "HP:0011177" ; a owl:Class ; rdfs:comment "EEG background activity at 4-5/second is rare and unusual but not generally pathologic." ; rdfs:label "EEG with 4-5/second background activity" ; rdfs:subClassOf obo:HP_0011176 . obo:HP_0011178 obo:IAO_0000115 "EEG dominated by diffuse alpha-waves (8-13Hz)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:23:53Z" ; oboInOwl:hasDbXref "UMLS:C4023494" ; oboInOwl:id "HP:0011178" ; a owl:Class ; rdfs:comment "Alpha-EEG is a rare finding but not generally pathologic." ; rdfs:label "Alpha-EEG" ; rdfs:subClassOf obo:HP_0011176 . obo:HP_0011179 obo:IAO_0000115 "EEG dominated by diffuse beta-waves (>13 Hz)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:25:00Z" ; oboInOwl:hasDbXref "UMLS:C4023493" ; oboInOwl:hasExactSynonym "Beta wave electroencephalography" ; oboInOwl:id "HP:0011179" ; a owl:Class ; rdfs:comment "Beta-EEG is a rare finding but not generally pathologic." ; rdfs:label "Beta-EEG" ; rdfs:subClassOf obo:HP_0011176, obo:HP_0011202 . obo:HP_0011180 obo:IAO_0000115 "EEG dominated by diffuse beta waves (>13 Hz) with occipitally localized alpha waves (8-13 Hz)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:25:50Z" ; oboInOwl:hasDbXref "UMLS:C4023492" ; oboInOwl:id "HP:0011180" ; a owl:Class ; rdfs:comment "A partial beta-EEG is a rare finding but not generally pathologic." ; rdfs:label "Partial beta-EEG" ; rdfs:subClassOf obo:HP_0011179 . obo:HP_0011181 obo:IAO_0000115 "EEG with an amplitude less than 30 microvolts without observable occipital alpha rhythm (8-13 Hz)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:27:20Z" ; oboInOwl:hasDbXref "UMLS:C1851759" ; oboInOwl:id "HP:0011181" ; a owl:Class ; rdfs:comment "A low voltage EEG is a rare finding but not generally pathologic." ; rdfs:label "Low voltage EEG" ; rdfs:subClassOf obo:HP_0011176 . obo:HP_0011182 obo:IAO_0000115 "Epileptiform activity refers to distinctive EEG waves or complexes distinguished from background activity found in in a proportion of human subjects with epilepsy, but which can also be found in subjects without seizures. Interictal epileptiform activity refers to such activity that occurs in the absence of a clinical or subclinical seizure." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:32:25Z" ; oboInOwl:hasDbXref "UMLS:C4023491" ; oboInOwl:hasExactSynonym "Epileptiform EEG discharges" ; oboInOwl:id "HP:0011182" ; a owl:Class ; rdfs:comment "Epileptiform EEG discharges include small sharp spikes (SSSs), wicket spikes, 14- and 6-Hz positive spikes, phantom spike and waves, psychomotor variant, subclinical rhythmic EEG discharges of adults (SREDA), and midline theta rhythm." ; rdfs:label "Interictal epileptiform activity" ; rdfs:subClassOf obo:HP_0025373 . obo:HP_0011183 obo:IAO_0000115 "Focal epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:36:34Z" ; oboInOwl:hasDbXref "UMLS:C4023490" ; oboInOwl:id "HP:0011183" ; a owl:Class ; rdfs:label "EEG with hyperventilation-induced focal epileptiform discharges" ; rdfs:subClassOf obo:HP_0010858 . obo:HP_0011184 obo:IAO_0000115 "Generalized epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:37:49Z" ; oboInOwl:hasDbXref "UMLS:C4023489" ; oboInOwl:hasExactSynonym "EEG with hyperventilation-induced generalised epileptiform discharges" ; oboInOwl:id "HP:0011184" ; a owl:Class ; rdfs:label "EEG with hyperventilation-induced generalized epileptiform discharges" ; rdfs:subClassOf obo:HP_0010858 . obo:HP_0011185 obo:IAO_0000115 "EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:39:02Z" ; oboInOwl:hasAlternativeId "HP:0010840" ; oboInOwl:hasDbXref "UMLS:C4021199" ; oboInOwl:hasExactSynonym "Focal EEG Abnormality" ; oboInOwl:id "HP:0011185" ; a owl:Class ; rdfs:comment "Note that a focal EEG abnormality is not synonymous with \"focal epileptiform discharges\" because a focal EEG abnormality is not necessarily epileptiform (e.g., it could be a focal slowing)." ; rdfs:label "EEG with focal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011182 . obo:HP_0011186 obo:IAO_0000115 "Focal epileptiform discharges with spreading to contralateral hemisphere but without secondary generalization." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:40:22Z" ; oboInOwl:hasDbXref "UMLS:C4023488" ; oboInOwl:id "HP:0011186" ; a owl:Class ; rdfs:label "Focal epileptiform discharges with limited propagation to contralateral hemisphere" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011187 obo:IAO_0000115 "Focal epileptiform discharges with spreading to the hemisphere on the same side of the brain." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:43:06Z" ; oboInOwl:hasDbXref "UMLS:C4023487" ; oboInOwl:id "HP:0011187" ; a owl:Class ; rdfs:label "Focal EEG discharges with propagation to ipsilateral hemisphere" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011188 obo:IAO_0000115 "Focal EEG discharges that secondarily spread to both hemispheres and can then be recorded over the entire scalp." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:44:33Z" ; oboInOwl:hasDbXref "UMLS:C4023486" ; oboInOwl:hasExactSynonym "Focal EEG discharges with secondary generalisation" ; oboInOwl:id "HP:0011188" ; a owl:Class ; rdfs:label "Focal EEG discharges with secondary generalization" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011189 obo:IAO_0000115 "Epileptiform discharges being identified at multiple locations in both hemispheres." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:47:23Z" ; oboInOwl:hasDbXref "UMLS:C4023485" ; oboInOwl:id "HP:0011189" ; a owl:Class ; rdfs:label "Bilateral multifocal epileptiform discharges" ; rdfs:subClassOf obo:HP_0010841 . obo:HP_0011190 obo:IAO_0000115 "Epileptiform discharges identified at multiple locations temporarily in both hemispheres and temporarily in one hemisphere." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:48:14Z" ; oboInOwl:hasDbXref "UMLS:C4023484" ; oboInOwl:id "HP:0011190" ; a owl:Class ; rdfs:label "Uni- and bilateral multifocal epileptiform discharges" ; rdfs:subClassOf obo:HP_0010841 . obo:HP_0011191 obo:IAO_0000115 "Epileptiform discharges being identified at multiple locations in one hemisphere." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:48:51Z" ; oboInOwl:hasDbXref "UMLS:C4023483" ; oboInOwl:id "HP:0011191" ; a owl:Class ; rdfs:label "Unilateral multifocal epileptiform discharges" ; rdfs:subClassOf obo:HP_0010841 . obo:HP_0011192 obo:IAO_0000115 "Focal epileptiform discharges of different shapes and frequencies." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:49:45Z" ; oboInOwl:hasDbXref "UMLS:C4023482" ; oboInOwl:id "HP:0011192" ; a owl:Class ; rdfs:label "Polymorphic focal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011193 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:50:36Z" ; oboInOwl:hasDbXref "UMLS:C4023481" ; oboInOwl:id "HP:0011193" ; a owl:Class ; rdfs:label "EEG with focal spikes" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011194 obo:IAO_0000115 "Focal spikes occurring for several seconds." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T10:51:41Z" ; oboInOwl:hasDbXref "UMLS:C4023480" ; oboInOwl:id "HP:0011194" ; a owl:Class ; rdfs:label "EEG with series of focal spikes" ; rdfs:subClassOf obo:HP_0011193 . obo:HP_0011195 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:02:29Z" ; oboInOwl:hasDbXref "UMLS:C4023479" ; oboInOwl:id "HP:0011195" ; a owl:Class ; rdfs:label "EEG with focal sharp slow waves" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011196 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:11:50Z" ; oboInOwl:hasDbXref "UMLS:C4023478" ; oboInOwl:id "HP:0011196" ; a owl:Class ; rdfs:label "EEG with focal sharp waves" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011197 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:12:45Z" ; oboInOwl:hasDbXref "UMLS:C4023477" ; oboInOwl:id "HP:0011197" ; a owl:Class ; rdfs:label "EEG with focal spike waves" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011198 obo:IAO_0000115 "EEG discharges recorded on the entire scalp typically seen in persons with epilepsy." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:15:46Z" ; oboInOwl:hasAlternativeId "HP:0010842" ; oboInOwl:hasDbXref "UMLS:C4023476" ; oboInOwl:hasExactSynonym "EEG with generalised epileptiform discharges" ; oboInOwl:id "HP:0011198" ; a owl:Class ; rdfs:comment "Spikes (<70 ms) and sharp waves (70-200 ms) are sharp transient waves that have a strong association with epilepsy. No difference is noted in terms of clinical significance of spikes and sharp waves. Significant spikes usually are followed by a slow wave." ; rdfs:label "EEG with generalized epileptiform discharges" ; rdfs:subClassOf obo:HP_0011182 . obo:HP_0011199 obo:IAO_0000115 "EEG with generalized sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:17:38Z" ; oboInOwl:hasDbXref "UMLS:C4023475" ; oboInOwl:hasExactSynonym "EEG with generalised sharp slow waves" ; oboInOwl:id "HP:0011199" ; a owl:Class ; rdfs:label "EEG with generalized sharp slow waves" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0011200 obo:IAO_0000115 "Generalized epileptiform discharges of different shapes and frequencies." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:19:04Z" ; oboInOwl:hasDbXref "UMLS:C4023474" ; oboInOwl:hasExactSynonym "EEG with generalised polymorphic epileptiform discharges" ; oboInOwl:id "HP:0011200" ; a owl:Class ; rdfs:label "EEG with generalized polymorphic epileptiform discharges" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0011201 obo:IAO_0000115 "EEG with abnormal amplitude." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:20:13Z" ; oboInOwl:hasDbXref "UMLS:C4023473" ; oboInOwl:id "HP:0011201" ; a owl:Class ; rdfs:label "EEG with changes in voltage" ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0011202 obo:IAO_0000115 "EEG frequency is abnormally increased." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:23:55Z" ; oboInOwl:hasDbXref "UMLS:C4023472" ; oboInOwl:id "HP:0011202" ; a owl:Class ; rdfs:label "EEG with diffuse acceleration" ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0011203 obo:IAO_0000115 "EEG with abnormally slow frequencies." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:26:47Z" ; oboInOwl:hasDbXref "UMLS:C4023471" ; oboInOwl:id "HP:0011203" ; a owl:Class ; rdfs:label "EEG with abnormally slow frequencies" ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0011204 obo:IAO_0000115 "EEG showing diffuse slowing without interruption." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:28:47Z" ; oboInOwl:hasDbXref "UMLS:C4023470" ; oboInOwl:id "HP:0011204" ; a owl:Class ; rdfs:label "EEG with continuous slow activity" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011205 obo:IAO_0000115 "Non-continuous diffuse slowing of electroencephalographic patterns." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:30:20Z" ; oboInOwl:hasDbXref "UMLS:C4023469" ; oboInOwl:id "HP:0011205" ; a owl:Class ; rdfs:label "EEG with intermittent slow activity" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011206 obo:IAO_0000115 "Slowing at frequencies between 7.5 and 8.5 Hz." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T11:31:28Z" ; oboInOwl:hasDbXref "UMLS:C4023468" ; oboInOwl:hasExactSynonym "EEG with generalised slow activity grade 1" ; oboInOwl:id "HP:0011206" ; a owl:Class ; rdfs:label "EEG with generalized slow activity grade 1" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011207 obo:IAO_0000115 "Generalized slowing of EEG activity at frequencies between 4-7 Hz." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:42:03Z" ; oboInOwl:hasDbXref "UMLS:C4023467" ; oboInOwl:hasExactSynonym "EEG with generalised slow activity grade 2" ; oboInOwl:id "HP:0011207" ; a owl:Class ; rdfs:label "EEG with generalized slow activity grade 2" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011208 obo:IAO_0000115 "Generalized slowing of EEG activity at frequencies between 0.5-3 Hz." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:44:11Z" ; oboInOwl:hasDbXref "UMLS:C4023466" ; oboInOwl:hasExactSynonym "EEG with generalised slow activity grade 3" ; oboInOwl:id "HP:0011208" ; a owl:Class ; rdfs:label "EEG with generalized slow activity grade 3" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011209 obo:IAO_0000115 "EEG without electrical activity." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:46:05Z" ; oboInOwl:hasDbXref "UMLS:C4021198" ; oboInOwl:hasExactSynonym "EEG with generalised slow activity grade 4", "Flat line EEG" ; oboInOwl:id "HP:0011209" ; a owl:Class ; rdfs:label "EEG with generalized slow activity grade 4" ; rdfs:subClassOf obo:HP_0010845 . obo:HP_0011210 obo:IAO_0000115 "Slowing in occipital areas of the scalp EEG." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:55:32Z" ; oboInOwl:hasDbXref "UMLS:C4023465" ; oboInOwl:id "HP:0011210" ; a owl:Class ; rdfs:label "EEG with occipital slowing" ; rdfs:subClassOf obo:HP_0010843 . obo:HP_0011211 obo:IAO_0000115 "Occurrence of epileptiform discharges in occipital regions during photic stimulation." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:59:07Z" ; oboInOwl:hasDbXref "UMLS:C4023464" ; oboInOwl:id "HP:0011211" ; a owl:Class ; rdfs:label "EEG with photoparoxysmal response grade I" ; rdfs:subClassOf obo:HP_0010852 . obo:HP_0011212 obo:IAO_0000115 "Occurence of epileptiform discharges in occipital and central regions during photic stimulation." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:59:32Z" ; oboInOwl:hasDbXref "UMLS:C4023463" ; oboInOwl:id "HP:0011212" ; a owl:Class ; rdfs:label "EEG with photoparoxysmal response grade II" ; rdfs:subClassOf obo:HP_0010852 . obo:HP_0011213 obo:IAO_0000115 "Occurrence of epileptiform discharges in occipital, central, temporal and parietal regions during photic stimulation." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T12:59:57Z" ; oboInOwl:hasDbXref "UMLS:C4023462" ; oboInOwl:id "HP:0011213" ; a owl:Class ; rdfs:label "EEG with photoparoxysmal response grade III" ; rdfs:subClassOf obo:HP_0010852 . obo:HP_0011214 obo:IAO_0000115 "Occurrence of generalized epileptiform discharges during photic stimulation." ; dcterms:creator ; oboInOwl:creation_date "2011-11-19T01:01:38Z" ; oboInOwl:hasDbXref "UMLS:C4023461" ; oboInOwl:id "HP:0011214" ; a owl:Class ; rdfs:label "EEG with photoparoxysmal response grade IV" ; rdfs:subClassOf obo:HP_0010852 . obo:HP_0011215 obo:IAO_0000115 "Hypsarrhythmia occurring in one hemisphere." ; dcterms:creator ; oboInOwl:creation_date "2011-11-29T07:42:18Z" ; oboInOwl:hasDbXref "UMLS:C4023460" ; oboInOwl:id "HP:0011215" ; a owl:Class ; rdfs:label "Hemihypsarrhythmia" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0011217 obo:IAO_0000115 "An abnormal shape of occiput." ; dcterms:creator ; oboInOwl:creation_date "2011-12-03T10:14:06Z" ; oboInOwl:hasBroadSynonym "Abnormal shape of posterior head", "Abnormal shape of the back of the head" ; oboInOwl:hasDbXref "UMLS:C4023459" ; oboInOwl:hasExactSynonym "Abnormal shape of posterior cranium", "Abnormal shape of posterior skull", "Abnormal shape of the back of the skull" ; oboInOwl:id "HP:0011217" ; a owl:Class ; rdfs:label "Abnormal shape of the occiput" ; rdfs:subClassOf obo:HP_0012294 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011218 obo:IAO_0000115 "An abnormal shape of the frontal part of the head." ; dcterms:creator ; oboInOwl:creation_date "2011-12-03T10:26:03Z" ; oboInOwl:hasDbXref "UMLS:C4023458" ; oboInOwl:hasExactSynonym "Abnormal morphology of the frontal region", "Abnormal shape of the forehead", "Dysmorphic forehead", "Dysmorphic frontal region" ; oboInOwl:id "HP:0011218" ; a owl:Class ; rdfs:label "Abnormal shape of the frontal region" ; rdfs:subClassOf obo:HP_0430000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001870 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011219 obo:IAO_0000115 "Facial height (length) is more than two standard deviations below the mean (objective); or an apparent decrease in the height (length) of the face (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2011-12-07T09:01:18Z" ; oboInOwl:hasDbXref "UMLS:C4023457" ; oboInOwl:hasExactSynonym "Decreased height of face", "Decreased length of face", "Decreased vertical dimension of face", "Short face", "Short facies", "Vertical Facial Deficiency", "Vertical deficiency of face", "Vertical facial insufficiency", "Vertical hypoplasia of face", "Vertical insufficiency of face", "Vertical shortening of face" ; oboInOwl:id "HP:0011219" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Objective measurement of face height is made with sliding calipers from the nasion, just above the depth of the nasal root to the gnathion, the inferior border of the mandible, both in the midline. Note that short face is distinct from wide face." ; rdfs:label "Short face" ; rdfs:subClassOf obo:HP_0000274 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011220 obo:IAO_0000115 "Forward prominence of the entire forehead, due to protrusion of the frontal bone." ; dcterms:creator ; oboInOwl:creation_date "2011-12-07T09:49:36Z" ; oboInOwl:hasAlternativeId "HP:0200061" ; oboInOwl:hasDbXref "UMLS:C1837260", "UMLS:C1867446" ; oboInOwl:hasExactSynonym "Prominence of frontal region", "Prominent forehead", "Pronounced forehead", "Protruding forehead" ; oboInOwl:hasRelatedSynonym "Bulging forehead" ; oboInOwl:id "HP:0011220" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Not to be confused with frontal bossing." ; rdfs:label "Prominent forehead" ; rdfs:subClassOf obo:HP_0000290 . obo:HP_0011221 obo:IAO_0000115 "Vertical soft tissue creases in the midline of the forehead, often extending from the hairline to the brow, and seen with facial expression or when the face is at rest." ; dcterms:creator ; oboInOwl:creation_date "2011-12-07T09:55:15Z" ; oboInOwl:hasDbXref "UMLS:C4023456" ; oboInOwl:hasExactSynonym "Frontal creases of face", "Vertical forehead creases", "Vertical forehead rhytids", "Vertical forehead wrinkles" ; oboInOwl:id "HP:0011221" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vertical forehead creases" ; rdfs:subClassOf obo:HP_0000290 . obo:HP_0011222 obo:IAO_0000115 "Posterior positioning of the glabella, i.e., of the midline forehead between the supraorbital ridges." ; dcterms:creator ; oboInOwl:creation_date "2011-12-07T10:03:30Z" ; oboInOwl:hasDbXref "UMLS:C4023455" ; oboInOwl:hasExactSynonym "Concave glabella", "Deficiency of glabella", "Deficient area between the eyebrows", "Flat area between the eyebrows", "Flat glabella", "Hypoplasia of glabella" ; oboInOwl:id "HP:0011222" ; a owl:Class ; rdfs:comment "The glabella is the area of the forehead in the midline between the supraorbital ridges, just above the nasal root." ; rdfs:label "Depressed glabella" ; rdfs:subClassOf obo:HP_0002056 . obo:HP_0011223 obo:IAO_0000115 "Linear vertical groove in the midline of the forehead, extending from hairline to glabella." ; dcterms:creator ; oboInOwl:creation_date "2011-12-07T10:34:38Z" ; oboInOwl:hasDbXref "UMLS:C4023454" ; oboInOwl:hasExactSynonym "Depression of frontal cranial suture", "Depression of metopic cranial suture", "Frontal suture depression" ; oboInOwl:id "HP:0011223" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Metopic depression" ; rdfs:subClassOf obo:HP_0005556 . obo:HP_0011224 obo:IAO_0000115 "Absent eyelids." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T07:58:12Z" ; oboInOwl:hasAlternativeId "HP:0009925" ; oboInOwl:hasDbXref "SNOMEDCT_US:13401001", "SNOMEDCT_US:708541009", "UMLS:C0266574", "UMLS:C4020757" ; oboInOwl:hasExactSynonym "Ablepharon of eyelid", "Absent eyelids", "Agenesis of eyelids", "Missing eyelids" ; oboInOwl:hasRelatedSynonym "Aplasia of the eyelids" ; oboInOwl:id "HP:0011224" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In ablepharon, the globe is continuously exposed. It is arguable whether true aplasia of the eyelid exists, or whether this represents severe hypoplasia. Nevertheless, as it is difficult or impossible to make this distinction on clinical grounds, the term was felt to be useful." ; rdfs:label "Ablepharon" ; rdfs:subClassOf obo:HP_0011226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011225 obo:IAO_0000115 "Redundant eyelid skin pressing the eyelashes against the cornea and/or conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T08:28:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253212001", "UMLS:C0344503" ; oboInOwl:id "HP:0011225" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Epiblepharon should be distinguished from entropion." ; rdfs:label "Epiblepharon" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0011226 obo:IAO_0000115 "Absence or underdevelopment of the eyelid." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T08:38:23Z" ; oboInOwl:hasDbXref "UMLS:C4023453" ; oboInOwl:hasExactSynonym "Failure of development of eyelid", "Hypotrophic eyelid" ; oboInOwl:id "HP:0011226" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the eyelid" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011227 obo:IAO_0000115 "An abnormal elevation of the C-reactive protein level in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T11:04:10Z" ; oboInOwl:hasDbXref "UMLS:C0742906", "UMLS:C4023452" ; oboInOwl:hasExactSynonym "Elevated C-reactive protein level" ; oboInOwl:hasRelatedSynonym "Elevated CRP" ; oboInOwl:id "HP:0011227" ; a owl:Class ; rdfs:comment "C-reactive protein (CRP) is produced by the liver, and increases in concentration in response to inflammation." ; rdfs:label "Elevated circulating C-reactive protein concentration" ; rdfs:subClassOf obo:HP_0032436, obo:HP_0033331 . obo:HP_0011228 obo:IAO_0000115 "An eyebrow that extends straight across the brow, without curve." ; dcterms:creator ; oboInOwl:creation_date "2011-12-14T08:18:29Z" ; oboInOwl:hasBroadSynonym "Lack of eyebrow arch", "Lack of eyebrow curvature" ; oboInOwl:hasDbXref "UMLS:C3277019" ; oboInOwl:hasExactSynonym "Flat eyebrow", "Horizontal eyebrow", "Straight eyebrow" ; oboInOwl:hasRelatedSynonym "Straight eyebrows" ; oboInOwl:id "HP:0011228" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Horizontal eyebrow" ; rdfs:subClassOf obo:HP_0000534 . obo:HP_0011229 obo:IAO_0000115 "Regional increase in the width (height) of the eyebrow." ; dcterms:creator ; oboInOwl:creation_date "2011-12-14T08:21:26Z" ; oboInOwl:hasDbXref "UMLS:C1856121" ; oboInOwl:hasExactSynonym "Broad eyebrow", "Broad eyebrows", "Flared eyebrow", "Increased vertical height of eyebrow", "Increased vertical thickness of eyebrow" ; oboInOwl:hasRelatedSynonym "Flared eyebrows", "Increased vertical width of eyebrow" ; oboInOwl:id "HP:0011229" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Broadening or flaring can be medial or lateral. Flaring is used to describe a widening with a change in direction of the eyebrow hairs." ; rdfs:label "Broad eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011230 obo:IAO_0000115 "An eyebrow that extends laterally beyond the orbital rim rather than turning gently downward at that location." ; dcterms:creator ; oboInOwl:creation_date "2011-12-14T08:27:22Z" ; oboInOwl:hasDbXref "UMLS:C4023451" ; oboInOwl:hasExactSynonym "Increased lateral length of eyebrow", "Laterally elongated eyebrow", "Laterally extended eyebrows" ; oboInOwl:id "HP:0011230" ; a owl:Class ; rdfs:comment "The degree of extension beyond the obital rim that is considered abnormal has not been established." ; rdfs:label "Laterally extended eyebrow" ; rdfs:subClassOf obo:HP_0000534 . obo:HP_0011231 obo:IAO_0000115 "Eyelashes that draw the attention of the viewer due to increased density and/or length and/or curl without meeting the criteria of trichomegaly." ; dcterms:creator ; oboInOwl:creation_date "2011-12-14T08:31:24Z" ; oboInOwl:hasDbXref "UMLS:C1835802", "UMLS:C4023450" ; oboInOwl:hasExactSynonym "Prominent eyelashes" ; oboInOwl:hasNarrowSynonym "Thick eyelashes" ; oboInOwl:id "HP:0011231" ; a owl:Class ; rdfs:label "Prominent eyelashes" ; rdfs:subClassOf obo:HP_0000499 . obo:HP_0011232 obo:IAO_0000115 "Elevated ridge(s) of skin starting well below the medial aspect of the lower lid that curves gradually upward toward and/or across the nasal bridge." ; dcterms:creator ; oboInOwl:creation_date "2011-12-14T07:00:48Z" ; oboInOwl:hasDbXref "UMLS:C4023449" ; oboInOwl:hasExactSynonym "Infraorbital fold" ; oboInOwl:hasRelatedSynonym "Dennie-Morgan fold" ; oboInOwl:id "HP:0011232" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term excludes epicanthus inversus." ; rdfs:label "Infra-orbital fold" ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0011233 obo:IAO_0000115 "Antihelix protrusion directed more anteriorly than laterally, forming a shelf overlying the posterior concha." ; dcterms:creator ; oboInOwl:creation_date "2011-12-15T07:03:37Z" ; oboInOwl:hasDbXref "UMLS:C4021197" ; oboInOwl:hasExactSynonym "Conchal shelf" ; oboInOwl:id "HP:0011233" ; a owl:Class ; rdfs:comment "In marked cases this often appears to be associated with lack of lateral protrusion of the antihelix." ; rdfs:label "Antihelical shelf" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011234 obo:IAO_0000115 "No discernible ridge between concha and triangular fossa and helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-15T07:09:03Z" ; oboInOwl:hasDbXref "UMLS:C4023448" ; oboInOwl:id "HP:0011234" ; a owl:Class ; rdfs:comment "This finding is common in a protruding and cupped ear, where the superior and inferior parts of the antihelix are often absent. This is distinct from partial absence of the antihelix as may occur in, for example, underdeveloped inferior crus of the antihelix." ; rdfs:label "Absent antihelix" ; rdfs:subClassOf obo:HP_0009738 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011235 obo:IAO_0000115 "Supernumerary ridge or crus of the ear arising from the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-15T07:16:54Z" ; oboInOwl:hasDbXref "UMLS:C4023447" ; oboInOwl:id "HP:0011235" ; a owl:Class ; rdfs:comment "The supernumerary crus usually emanates posteriorly from the antihelix at, or just above, the point of its bifurcation but may have a different origin. In the former case, the finding is termed Stahl ear." ; rdfs:label "Additional crus of antihelix" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011236 obo:IAO_0000115 "Antihelical ridge that forms an acute angle between the antitragus and its bifurcation (stem) instead of a gently curving arc." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T10:42:17Z" ; oboInOwl:hasDbXref "UMLS:C4023446" ; oboInOwl:id "HP:0011236" ; a owl:Class ; rdfs:label "Angulated antihelix" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011237 obo:IAO_0000115 "Increased width of the inferred cross-section of the inferior crus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T10:46:34Z" ; oboInOwl:hasDbXref "UMLS:C4021196" ; oboInOwl:hasExactSynonym "Antihelix, inferior crus, broad" ; oboInOwl:id "HP:0011237" ; a owl:Class ; rdfs:comment "This finding is highly variable. The inferior crus is usually sharply folded giving a narrow profile." ; rdfs:label "Broad inferior crus of antihelix" ; rdfs:subClassOf obo:HP_0011243 . obo:HP_0011238 obo:IAO_0000115 "Increased protrusion of the inferior crus relative to the prominence of the antihelix stem." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:24:43Z" ; oboInOwl:hasDbXref "UMLS:C4021195" ; oboInOwl:hasExactSynonym "Antihelix, inferior crus, prominent", "Hyperplastic inferior crus of antihelix", "Hypertrophic inferior crus of antihelix" ; oboInOwl:id "HP:0011238" ; a owl:Class ; rdfs:label "Prominent inferior crus of antihelix" ; rdfs:subClassOf obo:HP_0011243 . obo:HP_0011239 obo:IAO_0000115 "Decreased protrusion of the inferior crus relative to the prominence of the antihelix stem." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:27:15Z" ; oboInOwl:hasDbXref "UMLS:C4021194" ; oboInOwl:hasExactSynonym "Antihelix, inferior crus, underdeveloped", "Hypoplastic inferior crus of antihelix", "Hypotrophic inferior crus of antihelix" ; oboInOwl:id "HP:0011239" ; a owl:Class ; rdfs:comment "This finding is highly variable." ; rdfs:label "Underdeveloped inferior crus of antihelix" ; rdfs:subClassOf obo:HP_0011243 . obo:HP_0011240 obo:IAO_0000115 "Increased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of the helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:32:08Z" ; oboInOwl:hasDbXref "UMLS:C4020910" ; oboInOwl:hasExactSynonym "Hyperplastic antihelix stem", "Hypertrophic antihelix stem" ; oboInOwl:id "HP:0011240" ; a owl:Class ; rdfs:comment "This finding is highly variable. The relative prominence is attributable to either increased volume of the cartilage and/or the acuteness of the folding angle. Interpretation of relative antihelical prominence may be difficult when the conchal anatomy is distorted, for example, with a cupped ear." ; rdfs:label "Prominent stem of antihelix" ; rdfs:subClassOf obo:HP_0011244 . obo:HP_0011241 obo:IAO_0000115 "Posterior curving of the antihelix from its origin at the antitragus, traveling initially almost perpendicular to the descending helix and obscuring some of the concha." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:35:53Z" ; oboInOwl:hasDbXref "UMLS:C4021193" ; oboInOwl:hasExactSynonym "Antihelix, stem, serpiginous" ; oboInOwl:id "HP:0011241" ; a owl:Class ; rdfs:label "Serpiginous stem of antihelix" ; rdfs:subClassOf obo:HP_0011244 . obo:HP_0011242 obo:IAO_0000115 "Decreased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of a normal helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:38:15Z" ; oboInOwl:hasDbXref "UMLS:C4021192" ; oboInOwl:hasExactSynonym "Antihelix, stem, underdeveloped" ; oboInOwl:id "HP:0011242" ; a owl:Class ; rdfs:comment "The degree of prominence of the stem is highly variable and is attributable to the volume of the cartilage and/or the acuteness of the folding angle. Interpretation of degree of antihelical prominence may be difficult when the conchal anatomy is distorted, e.g., in cupped ear." ; rdfs:label "Underdeveloped stem of antihelix" ; rdfs:subClassOf obo:HP_0011244 . obo:HP_0011243 obo:IAO_0000115 "An abnormality of the inferior crus of the antihelix is the lower cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:41:44Z" ; oboInOwl:hasDbXref "UMLS:C4021191" ; oboInOwl:hasExactSynonym "Abnormality of anterior crus of antihelix" ; oboInOwl:id "HP:0011243" ; a owl:Class ; rdfs:comment "The inferior antihelical crus runs in an anterior and slightly superior direction, and is usually sharply defined, and appears less variable than its superior counterpart. A synonym is anterior crus of the antihelix." ; rdfs:label "Abnormality of inferior crus of antihelix" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011244 obo:IAO_0000115 "An abnormality of the stem of the antihelix, which is the part below the bifurcation of the antihelix into the inferior and superior crura." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:50:01Z" ; oboInOwl:hasDbXref "UMLS:C4023445" ; oboInOwl:id "HP:0011244" ; a owl:Class ; rdfs:label "Abnormality of stem of antihelix" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011245 obo:IAO_0000115 "An abnormality of the superior crus of the antihelix is the upper cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T11:52:06Z" ; oboInOwl:hasDbXref "UMLS:C4021190" ; oboInOwl:hasExactSynonym "Abnormality of posterior crus of antihelix" ; oboInOwl:id "HP:0011245" ; a owl:Class ; rdfs:comment "The inferior antihelical crus runs in an anterior and slightly superior direction, and is usually sharply defined, and appears less variable than its superior counterpart. A synonym is anterior crus of the antihelix." ; rdfs:label "Abnormality of superior crus of antihelix" ; rdfs:subClassOf obo:HP_0009738 . obo:HP_0011246 obo:IAO_0000115 "Decreased protrusion of the superior crus relative to the prominence of a normal antihelix stem." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T12:00:18Z" ; oboInOwl:hasDbXref "UMLS:C4021189" ; oboInOwl:hasExactSynonym "Hypoplastic superior crus of antihelix", "Hypotrophic superior crus of antihelix" ; oboInOwl:id "HP:0011246" ; a owl:Class ; rdfs:comment "This finding is highly variable. There may be an inverse relationship between the relative sizes of the superior and inferior crura, but these findings should be coded separately." ; rdfs:label "Underdeveloped superior crus of antihelix" ; rdfs:subClassOf obo:HP_0011245 . obo:HP_0011247 obo:IAO_0000115 "Increased protrusion of the superior crus relative to the prominence of a normal antihelix stem." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T12:02:57Z" ; oboInOwl:hasDbXref "UMLS:C4021188" ; oboInOwl:hasExactSynonym "Hyperplastic superior crus of antihelix", "Hypertrophic superior crus of antihelix" ; oboInOwl:id "HP:0011247" ; a owl:Class ; rdfs:comment "This finding is highly variable. There may be an inverse relationship between the relative sizes of the superior and inferior crura, but these findings should be coded separately." ; rdfs:label "Prominent superior crus of antihelix" ; rdfs:subClassOf obo:HP_0011245 . obo:HP_0011248 obo:IAO_0000115 "Positioning of the antitragus at an angle perpendicular to the plane of the ear (oriented away from the plane of the ear)." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T12:11:37Z" ; oboInOwl:hasDbXref "UMLS:C4023444" ; oboInOwl:id "HP:0011248" ; a owl:Class ; rdfs:label "Everted antitragus" ; rdfs:subClassOf obo:HP_0009896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001597 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011249 obo:IAO_0000115 "Absence of the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T12:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4023443" ; oboInOwl:id "HP:0011249" ; a owl:Class ; rdfs:comment "The size of the antitragus is highly variable." ; rdfs:label "Absent antitragus" ; rdfs:subClassOf obo:HP_0009896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011250 obo:IAO_0000115 "Double rather than single peak of the antitragus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T12:14:26Z" ; oboInOwl:hasDbXref "UMLS:C4021187" ; oboInOwl:hasExactSynonym "Double antitragus" ; oboInOwl:id "HP:0011250" ; a owl:Class ; rdfs:label "Bifid antitragus" ; rdfs:subClassOf obo:HP_0009896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011251 obo:IAO_0000115 "Reduction in the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T01:59:04Z" ; oboInOwl:hasDbXref "UMLS:C4021186" ; oboInOwl:hasExactSynonym "Hypoplastic antitragus", "Hypotrophic antitragus", "Small antitragus" ; oboInOwl:id "HP:0011251" ; a owl:Class ; rdfs:label "Underdeveloped antitragus" ; rdfs:subClassOf obo:HP_0009896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011252 obo:IAO_0000115 "Invagination of the superior part of the auricle under a fold of temporal skin." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T02:12:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:429967001", "UMLS:C2315717" ; oboInOwl:hasExactSynonym "Buried ear", "Hidden ear" ; oboInOwl:id "HP:0011252" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "There are associated anomalies of the upper antihelix and crura. The upper one-third of the auricle is primarily affected and there is an inferomedial displacement of the Helical Darwin tubercle. Two types are recognized. Type I: the antihelix and superior crus are reduced in size; type II: it is the antihelix and inferior crus that are affected." ; rdfs:label "Cryptotia" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0011253 obo:IAO_0000115 "A type of cryptotia associated with reduction in size of the antihelix and superior crus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T02:14:49Z" ; oboInOwl:hasDbXref "UMLS:C4023442" ; oboInOwl:hasExactSynonym "Type 1 cryptotia" ; oboInOwl:id "HP:0011253" ; a owl:Class ; rdfs:label "Type I cryptotia" ; rdfs:subClassOf obo:HP_0011252 . obo:HP_0011254 obo:IAO_0000115 "A type of cryptotia associated with reduction in size of the antihelix and inferior crus that are affected." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T02:15:48Z" ; oboInOwl:hasDbXref "UMLS:C4023441" ; oboInOwl:hasExactSynonym "Type 2 cryptotia" ; oboInOwl:id "HP:0011254" ; a owl:Class ; rdfs:label "Type II cryptotia" ; rdfs:subClassOf obo:HP_0011252 . obo:HP_0011255 obo:IAO_0000115 "Continuum between the tragus and ascending helix, without any evidence of a posterior extension (crus) towards the concha." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T05:50:59Z" ; oboInOwl:hasDbXref "UMLS:C4021185" ; oboInOwl:hasExactSynonym "Helix, crus, absent" ; oboInOwl:id "HP:0011255" ; a owl:Class ; rdfs:label "Absent crus of helix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0011256 obo:IAO_0000115 "Extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T05:51:54Z" ; oboInOwl:hasDbXref "UMLS:C4021184" ; oboInOwl:hasExactSynonym "Helix, crus, connected to antihelix" ; oboInOwl:id "HP:0011256" ; a owl:Class ; rdfs:label "Crus of helix connected to antihelix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0011257 obo:IAO_0000115 "Curving course of the crus of the helix, approaching or joining the antitragus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T05:56:25Z" ; oboInOwl:hasDbXref "UMLS:C4021183" ; oboInOwl:hasExactSynonym "Helix, crus, serpiginous" ; oboInOwl:id "HP:0011257" ; a owl:Class ; rdfs:label "Serpiginous crus of helix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0011258 obo:IAO_0000115 "The anterior origin of the crus encompasses the superior margin of the tragus, the crus overrides the upper portion of the conchal cavum and ends at the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T05:58:24Z" ; oboInOwl:hasDbXref "UMLS:C4021182" ; oboInOwl:hasExactSynonym "Helix, crus, tragal bridge" ; oboInOwl:id "HP:0011258" ; a owl:Class ; rdfs:label "Tragal bridge of crus of helix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0011259 obo:IAO_0000115 "Widening, rather than tapering, of the crus at its posterior border near the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T06:00:07Z" ; oboInOwl:hasDbXref "UMLS:C4021181" ; oboInOwl:hasExactSynonym "Helix, crus, expanded terminal portion" ; oboInOwl:id "HP:0011259" ; a owl:Class ; rdfs:label "Expanded terminal portion of crus of helix" ; rdfs:subClassOf obo:HP_0009895 . obo:HP_0011260 obo:IAO_0000115 "Small defect of the helical fold that lies at the junction of the superior and descending portions of the helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T06:01:45Z" ; oboInOwl:hasDbXref "UMLS:C4021180" ; oboInOwl:hasExactSynonym "Helix, Darwin notch" ; oboInOwl:id "HP:0011260" ; a owl:Class ; rdfs:label "Darwin notch of helix" ; rdfs:subClassOf obo:HP_0009902 . obo:HP_0011261 obo:IAO_0000115 "Small expansion of the helical fold at the junction of the superior and descending portions of the helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T06:02:42Z" ; oboInOwl:hasDbXref "UMLS:C4021179" ; oboInOwl:hasExactSynonym "Helix, Darwin tubercle" ; oboInOwl:id "HP:0011261" ; a owl:Class ; rdfs:label "Darwin tubercle of helix" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0011262 obo:IAO_0000115 "Linear, circumferential indentation in the convexity of the outer surface of the helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T06:19:33Z" ; oboInOwl:hasDbXref "UMLS:C4021178" ; oboInOwl:hasExactSynonym "Helix, crimped", "Indented helix" ; oboInOwl:id "HP:0011262" ; a owl:Class ; rdfs:comment "The crimp is usually found in the middle third of the descending helix. The helix has the appearance of having been pinched or flattened along its posterior margin. The crimp may distort the free margin of the helix." ; rdfs:label "Crimped helix" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0011263 obo:IAO_0000115 "Positioning of the anterior surface of the ear lobe in a more coronal plane than the remainder of the ear." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T06:50:34Z" ; oboInOwl:hasDbXref "UMLS:C4021177" ; oboInOwl:hasExactSynonym "Forward facing earlobe", "Lobe, forward facing" ; oboInOwl:id "HP:0011263" ; a owl:Class ; rdfs:comment "The lobe should be viewed from the front. This feature is distinct from the situation where the entire ear is forward facing and prominent. The lobe normally lies more or less in the same plane as the remainder of the ear. This feature should be distinguished from Uplifted lobe." ; rdfs:label "Forward facing earlobe" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0011264 obo:IAO_0000115 "Interruption between the ascending helix and the crus helix, allowing the ascending helix to be attached directly to the mastoid." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:31:00Z" ; oboInOwl:hasDbXref "UMLS:C4021176" ; oboInOwl:hasExactSynonym "Helix, discontinuous ascending root" ; oboInOwl:id "HP:0011264" ; a owl:Class ; rdfs:label "Discontinuous ascending root of helix" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0011265 obo:IAO_0000115 "Discontinuity in the convexity of the inferior margin of the lobe." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:39:52Z" ; oboInOwl:hasDbXref "UMLS:C4023440" ; oboInOwl:hasExactSynonym "Cleft earlobe" ; oboInOwl:id "HP:0011265" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The cleft is often more visible if the lobe is pulled forward or when seen from behind. Tears acquired from earrings should be distinguished." ; rdfs:label "Cleft earlobe" ; rdfs:subClassOf obo:HP_0000363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001847 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011266 obo:IAO_0000115 "Presence of all the normal ear components and the median longitudinal length more than two standard deviations below the mean." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:44:51Z" ; oboInOwl:hasAlternativeId "HP:0000379" ; oboInOwl:hasDbXref "UMLS:C4021175" ; oboInOwl:hasExactSynonym "First-degree microtia" ; oboInOwl:id "HP:0011266" ; a owl:Class ; rdfs:label "Microtia, first degree" ; rdfs:subClassOf obo:HP_0008551 . obo:HP_0011267 obo:IAO_0000115 "Presence of some auricular structures, but none of these structures conform to recognized ear components." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:49:49Z" ; oboInOwl:hasBroadSynonym "Abnormal shape/structure of ear" ; oboInOwl:hasDbXref "UMLS:C4021174", "UMLS:C4280331" ; oboInOwl:hasExactSynonym "Third-degree microtia" ; oboInOwl:id "HP:0011267" ; a owl:Class ; rdfs:comment "This malformation is commonly associated with atresia of the external canal, but that anomaly should be coded separately. Complete absence of the ear should be coded as Anotia." ; rdfs:label "Microtia, third degree" ; rdfs:subClassOf obo:HP_0008551 . obo:HP_0011268 obo:IAO_0000115 "Lack of convexity or prominence of the contour of the ridge between the bottom of the incisura and the confluence of the ascending helix and crus helix." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:55:39Z" ; oboInOwl:hasDbXref "UMLS:C4023439" ; oboInOwl:id "HP:0011268" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This appears to be unusual in an otherwise normal ear, and is most often seen in microtia with atretic auditory meatus, but those findings should be coded separately." ; rdfs:label "Absent tragus" ; rdfs:subClassOf obo:HP_0009913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011269 obo:IAO_0000115 "Increased height of the tragal ridge with a shallow indentation at the apex, giving the appearance of a double peak." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:56:56Z" ; oboInOwl:hasDbXref "UMLS:C4021173" ; oboInOwl:hasExactSynonym "Notched tragus", "Tragus, bifid" ; oboInOwl:id "HP:0011269" ; a owl:Class ; rdfs:label "Bifid tragus" ; rdfs:subClassOf obo:HP_0009912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011270 obo:IAO_0000115 "A complete or partial duplication of the tragus; expected to lie anterior to the normal tragus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T07:58:04Z" ; oboInOwl:hasDbXref "UMLS:C4021172" ; oboInOwl:hasExactSynonym "Accesory tragus", "Tragus, duplicated" ; oboInOwl:id "HP:0011270" ; a owl:Class ; rdfs:comment "It is unclear how often, or even whether, this feature which would represent a duplication of mandibular components, occurs. More common occurrences in this region would include preauricular tags and pretragial duplications of hyoid origin." ; rdfs:label "Duplicated tragus" ; rdfs:subClassOf obo:HP_0009912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011271 obo:IAO_0000115 "Increase posterolateral protrusion of the tragus." ; oboInOwl:creation_date "2011-12-18T07:59:22Z" ; oboInOwl:hasDbXref "UMLS:C4021171" ; oboInOwl:hasExactSynonym "Enlarged tragus", "Hyperplastic tragus", "Hypertrophic tragus", "Large tragus", "Tragus, prominent" ; oboInOwl:id "HP:0011271" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominent tragus" ; rdfs:subClassOf obo:HP_0009912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011272 obo:IAO_0000115 "Decreased posterolateral protrusion of the tragus." ; dcterms:creator ; oboInOwl:creation_date "2011-12-18T08:01:33Z" ; oboInOwl:hasDbXref "UMLS:C4013429" ; oboInOwl:hasExactSynonym "Hypoplastic tragus", "Hypotrophic tragus", "Small tragus" ; oboInOwl:id "HP:0011272" ; a owl:Class ; rdfs:label "Underdeveloped tragus" ; rdfs:subClassOf obo:HP_0009913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011273 obo:IAO_0000115 "Abnormally increased variability in the size of erythrocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-12-28T11:58:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165475005", "SNOMEDCT_US:57241006", "UMLS:C0221278" ; oboInOwl:hasExactSynonym "Unequal size of red blood cells" ; oboInOwl:id "HP:0011273" ; a owl:Class ; rdfs:label "Anisocytosis" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0011274 obo:IAO_0000115 "Increased susceptibility to mycobacterial infections, as manifested by recurrent episodes of mycobacterial infection." ; dcterms:creator ; oboInOwl:creation_date "2011-12-28T12:11:54Z" ; oboInOwl:hasDbXref "UMLS:C4023438" ; oboInOwl:id "HP:0011274" ; a owl:Class ; rdfs:comment "Mycobacteria represent a family of slowly growing bacteria, including M. tuberculosis, the agent of tuberculosis, M. leprae, the agent of leprosy, M. avium complex species, and others. Mycobacteria infection can be asymptomatic or not, and are typically difficult to treat with antibiotics." ; rdfs:label "Recurrent mycobacterial infections" ; rdfs:subClassOf obo:HP_0002718 . obo:HP_0011275 obo:IAO_0000115 "Increased susceptibility to mycobacterial avium complex infections, as manifested by recurrent episodes of mycobacterial infection." ; dcterms:creator ; oboInOwl:creation_date "2011-12-28T12:16:46Z" ; oboInOwl:hasDbXref "UMLS:C1737260" ; oboInOwl:id "HP:0011275" ; a owl:Class ; rdfs:comment "Mycobacterium avium complex (MAC) is a group of species including M. avium, M. avium paratuberculosis, and others. Disseminated MAC infections can be seen associated with HIV infection. Pulmonary disease and cervical adenitis are other sequellae of MAC infection." ; rdfs:label "Recurrent mycobacterium avium complex infections" ; rdfs:subClassOf obo:HP_0011274 . obo:HP_0011276 dcterms:creator ; oboInOwl:creation_date "2011-12-29T08:52:53Z" ; oboInOwl:hasDbXref "MSH:D017445", "SNOMEDCT_US:11263005", "UMLS:C0162819", "UMLS:C1842892" ; oboInOwl:hasExactSynonym "Skin vascular malformation" ; oboInOwl:hasRelatedSynonym "Vascular abnormalities restricted to skin" ; oboInOwl:id "HP:0011276" ; a owl:Class ; rdfs:label "Vascular skin abnormality" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0011354 . obo:HP_0011277 dcterms:creator ; oboInOwl:creation_date "2011-12-30T02:51:16Z" ; oboInOwl:hasDbXref "UMLS:C4023437" ; oboInOwl:id "HP:0011277" ; a owl:Class ; rdfs:label "Abnormality of the urinary system physiology" ; rdfs:subClassOf obo:HP_0000079 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001008 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011278 obo:IAO_0000115 "A type of pulmonary sequestration that occurs within the visceral pleura of normal lung tissue, usually without communication with the tracheobronchial tree." ; dcterms:creator ; oboInOwl:creation_date "2011-12-31T07:43:28Z" ; oboInOwl:hasDbXref "UMLS:C4023436" ; oboInOwl:id "HP:0011278" ; a owl:Class ; rdfs:label "Intrapulmonary sequestration" ; rdfs:subClassOf obo:HP_0100632 . obo:HP_0011279 obo:IAO_0000115 "An abnormal amount of hydrogencarbonate in the urine." ; dcterms:creator ; oboInOwl:creation_date "2011-12-30T02:57:55Z" ; oboInOwl:hasDbXref "UMLS:C4023435" ; oboInOwl:hasExactSynonym "Abnormality of urine HCO3 concentration" ; oboInOwl:id "HP:0011279" ; a owl:Class ; rdfs:label "Abnormality of urine bicarbonate level" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011280 obo:IAO_0000115 "An abnormality of calcium concentration in the urine." ; dcterms:creator ; oboInOwl:creation_date "2011-12-30T03:27:02Z" ; oboInOwl:hasDbXref "UMLS:C4023434" ; oboInOwl:hasExactSynonym "Abnormality of urine Ca concentration", "Abnormality of urine Ca2+ concentration" ; oboInOwl:id "HP:0011280" ; a owl:Class ; rdfs:label "Abnormality of urine calcium concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011281 obo:IAO_0000115 "An abnormal amount of urinary catecholamine concentration." ; dcterms:creator ; oboInOwl:creation_date "2011-12-30T03:35:18Z" ; oboInOwl:hasDbXref "MP:0011478", "UMLS:C4023433" ; oboInOwl:id "HP:0011281" ; a owl:Class ; rdfs:comment "Any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine." ; rdfs:label "Abnormality of urine catecholamine level" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011282 obo:IAO_0000115 "An abnormality of the hindbrain, also known as the rhombencephalon." ; dcterms:creator ; oboInOwl:creation_date "2012-01-01T01:22:36Z" ; oboInOwl:hasDbXref "UMLS:C4021170" ; oboInOwl:hasExactSynonym "Abnormal shape of hindbrain", "Abnormality of hindbrain morphology", "Abnormality of the hindbrain" ; oboInOwl:id "HP:0011282" ; a owl:Class ; rdfs:comment "The hindbrain consists of two main structures: The pons and the cerebellum." ; rdfs:label "Abnormal hindbrain morphology" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011283 obo:IAO_0000115 "An abnormality of the metencephalon. The metencephalon is the part of the hindbrain that consists of the pons and the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2012-01-01T01:24:14Z" ; oboInOwl:hasDbXref "UMLS:C4023432" ; oboInOwl:hasExactSynonym "Abnormality of the metencephalon" ; oboInOwl:id "HP:0011283" ; a owl:Class ; rdfs:label "Abnormal metencephalon morphology" ; rdfs:subClassOf obo:HP_0011282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001895 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011284 obo:IAO_0000115 "A type of aganglionic megacolon in which the aganglionic segment does not extend beyond the upper sigmoid." ; dcterms:creator ; oboInOwl:creation_date "2012-01-01T02:59:57Z" ; oboInOwl:hasDbXref "UMLS:C4023431" ; oboInOwl:id "HP:0011284" ; a owl:Class ; rdfs:label "Short-segment aganglionic megacolon" ; rdfs:subClassOf obo:HP_0002251 . obo:HP_0011285 obo:IAO_0000115 "A type of aganglionic megacolon in which the aganglionic segment extends proximal to the sigmoid." ; dcterms:creator ; oboInOwl:creation_date "2012-01-01T03:02:49Z" ; oboInOwl:hasDbXref "UMLS:C4023430" ; oboInOwl:id "HP:0011285" ; a owl:Class ; rdfs:label "Long-segment aganglionic megacolon" ; rdfs:subClassOf obo:HP_0002251 . obo:HP_0011286 obo:IAO_0000115 "A type of aganglionic megacolon in which the aganglionic segment comprises the entire colon." ; dcterms:creator ; oboInOwl:creation_date "2012-01-01T03:03:46Z" ; oboInOwl:hasDbXref "MSH:D006627", "SNOMEDCT_US:253780003", "SNOMEDCT_US:360441005", "UMLS:C0085758" ; oboInOwl:id "HP:0011286" ; a owl:Class ; rdfs:label "Total colonic aganglionosis" ; rdfs:subClassOf obo:HP_0002251 . obo:HP_0011287 obo:IAO_0000115 "EEG with sharp slow waves in the occipital region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:28:45Z" ; oboInOwl:hasDbXref "UMLS:C4023429" ; oboInOwl:id "HP:0011287" ; a owl:Class ; rdfs:label "EEG with occipital sharp slow waves" ; rdfs:subClassOf obo:HP_0011195, obo:HP_0033720 . obo:HP_0011288 obo:IAO_0000115 "EEG with sharp slow waves in the parietal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:29:59Z" ; oboInOwl:hasDbXref "UMLS:C4023428" ; oboInOwl:id "HP:0011288" ; a owl:Class ; rdfs:label "EEG with parietal sharp slow waves" ; rdfs:subClassOf obo:HP_0011195, obo:HP_0033719 . obo:HP_0011289 obo:IAO_0000115 "EEG with sharp slow waves in the temporal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:30:25Z" ; oboInOwl:hasDbXref "UMLS:C4023427" ; oboInOwl:id "HP:0011289" ; a owl:Class ; rdfs:label "EEG with temporal sharp slow waves" ; rdfs:subClassOf obo:HP_0011195, obo:HP_0033717 . obo:HP_0011290 obo:IAO_0000115 "EEG with sharp slow waves in the frontal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:30:41Z" ; oboInOwl:hasDbXref "UMLS:C4023426" ; oboInOwl:id "HP:0011290" ; a owl:Class ; rdfs:label "EEG with frontal sharp slow waves" ; rdfs:subClassOf obo:HP_0011195, obo:HP_0033716 . obo:HP_0011291 obo:IAO_0000115 "EEG with sharp slow waves in the central region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:31:02Z" ; oboInOwl:hasDbXref "UMLS:C4023425" ; oboInOwl:id "HP:0011291" ; a owl:Class ; rdfs:label "EEG with central sharp slow waves" ; rdfs:subClassOf obo:HP_0011195, obo:HP_0033718 . obo:HP_0011292 obo:IAO_0000115 "EEG with sharp waves in the occipital region, i.e., sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:31:29Z" ; oboInOwl:hasDbXref "UMLS:C2206521" ; oboInOwl:id "HP:0011292" ; a owl:Class ; rdfs:label "EEG with occipital sharp waves" ; rdfs:subClassOf obo:HP_0011196, obo:HP_0033720 . obo:HP_0011293 obo:IAO_0000115 "EEG with sharp waves in the central region, i.e., sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:32:48Z" ; oboInOwl:hasDbXref "UMLS:C2207327" ; oboInOwl:id "HP:0011293" ; a owl:Class ; rdfs:label "EEG with central sharp waves" ; rdfs:subClassOf obo:HP_0011196, obo:HP_0033718 . obo:HP_0011294 obo:IAO_0000115 "EEG with sharp waves in the frontal region, i.e., sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:33:10Z" ; oboInOwl:hasDbXref "UMLS:C2206518" ; oboInOwl:id "HP:0011294" ; a owl:Class ; rdfs:label "EEG with frontal sharp waves" ; rdfs:subClassOf obo:HP_0011196, obo:HP_0033716 . obo:HP_0011295 obo:IAO_0000115 "EEG with sharp waves in the parietal region, i.e., sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:33:29Z" ; oboInOwl:hasDbXref "UMLS:C2206520" ; oboInOwl:id "HP:0011295" ; a owl:Class ; rdfs:label "EEG with parietal sharp waves" ; rdfs:subClassOf obo:HP_0011196, obo:HP_0033719 . obo:HP_0011296 obo:IAO_0000115 "EEG with sharp waves in the temporal region, i.e., sharp transient waves of a duration between 80 and 200 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T12:33:47Z" ; oboInOwl:hasDbXref "UMLS:C2206519" ; oboInOwl:id "HP:0011296" ; a owl:Class ; rdfs:label "EEG with temporal sharp waves" ; rdfs:subClassOf obo:HP_0011196, obo:HP_0033717 . obo:HP_0011297 obo:IAO_0000115 "A morphological abnormality of a digit, i.e., of a finger or toe." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T07:16:22Z" ; oboInOwl:hasDbXref "UMLS:C3550704" ; oboInOwl:hasExactSynonym "Abnormality of digit", "Abnormality of fingers or toes", "Digital anomalies" ; oboInOwl:id "HP:0011297" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal digit morphology" ; rdfs:subClassOf obo:HP_0002813 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011298 obo:IAO_0000115 "A soft tissue prominence of the ventral aspects of the fingertips or toe tips." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T07:18:29Z" ; oboInOwl:hasDbXref "UMLS:C4023424" ; oboInOwl:hasExactSynonym "Prominent digit pad" ; oboInOwl:id "HP:0011298" ; a owl:Class ; rdfs:comment "The prominence of the finger or toe pads varies throughout life, being greater in neonates and dependent on the state of hydration. This term should not be used if the digit has clubbing. Note that the synonym \"fetal fingertip pads\" should not be interpreted to mean that the prominent pad necessarily was present in this individual since fetal life. We do not endorse the use of the term \"Persistent fetal pads\" as this term implies knowledge of the natural history of this finding, which may or may not be known." ; rdfs:label "Prominent digit pad" ; rdfs:subClassOf obo:HP_0011356 . obo:HP_0011299 obo:IAO_0000115 "The absence of a phalangeal segment of a finger." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T10:57:07Z" ; oboInOwl:hasDbXref "UMLS:C4023423" ; oboInOwl:hasExactSynonym "Partial absence of finger" ; oboInOwl:id "HP:0011299" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The part that is absent may be specified. The \"distal\" modifier specifies the loss of the distal phalanx; clinically this is defined by the absence of the nail. The \"proximal\" modifier specifies the loss of the proximal or middle phalanx with the nail still present and/or the radiographic finding of a remaining phalanx that is similar to a distal phalanx. It may be difficult to determine which phalanx is absent without x-rays and even then, there are circumstances where the missing bone may not be exactly identified (note that no attempt is made to distinguish missing middle from proximal phalanges). In this situation the location adjective will have to be removed. This finding is distinct from Short fingers." ; rdfs:label "Partial absence of finger" ; rdfs:subClassOf obo:HP_0005918 . obo:HP_0011300 obo:IAO_0000115 "Increased width of the distal segment of a finger." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T11:18:08Z" ; oboInOwl:hasDbXref "UMLS:C1968816" ; oboInOwl:hasExactSynonym "Broad fingertip", "Broad fingertips" ; oboInOwl:id "HP:0011300" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term should be reserved for use when the distal digit is significantly broader than the middle part. It should not be used if the digit has Clubbing or Macrodactyly or if the entire finger is broad. The distinction to the term Broad distal phalanx of finger is that this term is a clinical impression while Broad distal phalanx of finger refers to the objectively measured width of the distal phalane (bone), a radiological finding." ; rdfs:label "Broad fingertip" ; rdfs:subClassOf obo:HP_0001211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011301 obo:IAO_0000115 "The total absence of the foot, with no bony elements distal to the tibia or fibula." ; dcterms:creator ; oboInOwl:creation_date "2012-02-11T11:20:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:371197005", "UMLS:C0265624" ; oboInOwl:hasExactSynonym "Absent foot", "Aplasia of the foot", "Apodia" ; oboInOwl:id "HP:0011301" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Absent foot" ; rdfs:subClassOf obo:HP_0006494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011302 obo:IAO_0000115 "For children from birth to 16 years of age the length of the palm is more than the 97th centile; or, the length of the palm appears relatively long compared to the finger length or the limb length." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T10:20:56Z" ; oboInOwl:hasAlternativeId "HP:0001502" ; oboInOwl:hasDbXref "UMLS:C4023422" ; oboInOwl:hasExactSynonym "Long palm" ; oboInOwl:id "HP:0011302" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long palm" ; rdfs:subClassOf obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011303 obo:IAO_0000115 "The contour of the foot in lateral profile has a convex shape." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T11:06:12Z" ; oboInOwl:hasDbXref "UMLS:C4023421" ; oboInOwl:id "HP:0011303" ; a owl:Class ; rdfs:comment "This term was established as the convex contour may occur without the prominent heel, which together comprise the bundled term Rocker-bottom foot." ; rdfs:label "Convex contour of sole" ; rdfs:subClassOf obo:HP_0100872 . obo:HP_0011304 obo:IAO_0000115 "Increased thumb width without increased dorso-ventral dimension." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T11:15:31Z" ; oboInOwl:hasAlternativeId "HP:0001173", "HP:0001240", "HP:0004073", "HP:0009651" ; oboInOwl:hasDbXref "SNOMEDCT_US:249773003", "UMLS:C0426891" ; oboInOwl:hasExactSynonym "Broad phalanges of the thumb", "Broad thumb", "Broad thumbs", "Wide/broad thumb", "Wide/broad thumb phalanges" ; oboInOwl:id "HP:0011304" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Note that this term should not be used for thumbs that meet the definition for Macrodactyly." ; rdfs:label "Broad thumb" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0009768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011305 obo:IAO_0000115 "The absence of a phalangeal segment of a toe or hallux." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:20:32Z" ; oboInOwl:hasDbXref "UMLS:C4021169" ; oboInOwl:hasExactSynonym "Hypophalangy of toes", "Partial absence of toe" ; oboInOwl:id "HP:0011305" ; a owl:Class ; rdfs:comment "The part that is absent may be specified. The \"distal\" modifier specifies the loss of the distal phalanx; clinically this is defined by the absence of the nail. The \"proximal\" modifier specifies the loss of the proximal or middle phalanx with the nail still present. It may be difficult to know which phalanx is absent without X-rays and even then, the missing bone may not be identified (note no attempt is made to distinguish missing middle from proximal phalanges). In this situation the location adjective should be removed. Note that this finding is distinct from Short toes, (which are reduced in length but have the normal number of phalangeal segments). Partial absence of the hallux is an alternative term that may be used for the first toe." ; rdfs:label "Partial absence of toe" ; rdfs:subClassOf obo:HP_0010760 . obo:HP_0011307 obo:IAO_0000115 "Divergence of digits along the anteroposterior axis (in the plane of the sole)." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:38:36Z" ; oboInOwl:hasDbXref "UMLS:C2117390" ; oboInOwl:hasExactSynonym "Splayed toes" ; oboInOwl:id "HP:0011307" ; a owl:Class ; rdfs:label "Splayed toes" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0011308 obo:IAO_0000115 "Toes that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:39:51Z" ; oboInOwl:hasAlternativeId "HP:0200091" ; oboInOwl:hasDbXref "UMLS:C4021168" ; oboInOwl:hasExactSynonym "Narrow toe", "Slender toe" ; oboInOwl:id "HP:0011308" ; a owl:Class ; rdfs:label "Slender toe" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011309 obo:IAO_0000115 "The gradual reduction in girth of the toe from proximal to distal." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:41:30Z" ; oboInOwl:hasAlternativeId "HP:0008088", "HP:0200089" ; oboInOwl:hasDbXref "UMLS:C4021167" ; oboInOwl:hasExactSynonym "Tapered toe", "Tapering toes" ; oboInOwl:id "HP:0011309" ; a owl:Class ; rdfs:label "Tapered toe" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001500 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011310 obo:IAO_0000115 "A crease that connects the proximal and distal transverse palmar creases." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:56:40Z" ; oboInOwl:hasDbXref "UMLS:C4021166" ; oboInOwl:hasExactSynonym "Bridged palm line", "Transitional palmar crease" ; oboInOwl:id "HP:0011310" ; a owl:Class ; rdfs:comment "The crease that connects the two transverse creases should itself be more in the transverse (antero-posterior) than longitudinal (proximo-distal) orientation." ; rdfs:label "Bridged palmar crease" ; rdfs:subClassOf obo:HP_0010490 . obo:HP_0011311 obo:IAO_0000115 "Extension of the proximal transverse crease (five finger crease) to the ulnar edge of the palm." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T12:58:13Z" ; oboInOwl:hasDbXref "UMLS:C4023420" ; oboInOwl:id "HP:0011311" ; a owl:Class ; rdfs:comment "The proximal transverse (five finger) crease starts on the radial side of the hand near the base of the index finger and extends toward the ulnar side of the palm, but does not reach the ulnar side. In this finding, the crease extends completely to the ulnar margin of the palm." ; rdfs:label "Sydney crease" ; rdfs:subClassOf obo:HP_0010490 . obo:HP_0011312 obo:IAO_0000115 "A nail plate that has a longitudinal separation with partially separated nails, each with a separate lateral radius of curvature." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T01:12:22Z" ; oboInOwl:hasDbXref "UMLS:C4023419" ; oboInOwl:hasExactSynonym "Fused nails" ; oboInOwl:id "HP:0011312" ; a owl:Class ; rdfs:comment "The use of the word \"fused\" is not meant to imply that pathogenetically these nails were separate and merged. This is distinct from a split or cleaved nail, where the two parts of the nails share the same radius of curvature. The involved digits should be specified. It may be associated with underlying syndactylous digits, but these are coded separately." ; rdfs:label "Fused nails" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0011313 obo:IAO_0000115 "Decreased width of nail." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T01:33:34Z" ; oboInOwl:hasAlternativeId "HP:0200076" ; oboInOwl:hasDbXref "UMLS:C4021829" ; oboInOwl:hasExactSynonym "Narrow nail" ; oboInOwl:id "HP:0011313" ; a owl:Class ; rdfs:label "Narrow nail" ; rdfs:subClassOf obo:HP_0002164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011314 obo:IAO_0000115 "An abnormality of size or shape of the long bones." ; dcterms:creator ; oboInOwl:creation_date "2012-02-12T02:31:03Z" ; oboInOwl:hasAlternativeId "HP:0100713", "HP:0100714", "HP:0100715" ; oboInOwl:hasDbXref "UMLS:C4021165" ; oboInOwl:hasExactSynonym "Abnormal shape of long bone", "Abnormality of long bone morphology", "Abnormality of the tubular bones" ; oboInOwl:id "HP:0011314" ; a owl:Class ; rdfs:label "Abnormal long bone morphology" ; rdfs:subClassOf obo:HP_0011844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011315 obo:IAO_0000115 "Synostosis affecting only one of the coronal sutures." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:08:28Z" ; oboInOwl:hasDbXref "UMLS:C4020756", "UMLS:C4023418" ; oboInOwl:hasExactSynonym "Unilateral coronal suture craniosynostosis", "Unilateral coronal suture synostosis" ; oboInOwl:hasRelatedSynonym "Unilateral coronal craniosynostosis" ; oboInOwl:id "HP:0011315" ; a owl:Class ; rdfs:label "Unicoronal synostosis" ; rdfs:subClassOf obo:HP_0004440 . obo:HP_0011316 obo:IAO_0000115 "Synostosis affecting only the left coronal suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:10:32Z" ; oboInOwl:hasDbXref "UMLS:C4023417" ; oboInOwl:id "HP:0011316" ; a owl:Class ; rdfs:label "Left unicoronal synostosis" ; rdfs:subClassOf obo:HP_0011315 . obo:HP_0011317 obo:IAO_0000115 "Unicoronal synostosis affecting only the right coronal suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:11:21Z" ; oboInOwl:hasDbXref "UMLS:C4023416" ; oboInOwl:id "HP:0011317" ; a owl:Class ; rdfs:label "Right unicoronal synostosis" ; rdfs:subClassOf obo:HP_0011315 . obo:HP_0011318 obo:IAO_0000115 "Synostosis affecting the right and the left coronal suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:11:41Z" ; oboInOwl:hasDbXref "UMLS:C4021164" ; oboInOwl:hasExactSynonym "Bilateral coronal craniosynostosis", "Bilateral coronal suture craniosynostosis", "Bilateral coronal suture synostosis" ; oboInOwl:id "HP:0011318" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bicoronal synostosis" ; rdfs:subClassOf obo:HP_0004440 . obo:HP_0011319 obo:IAO_0000115 "Premature synostosis of both lambdoid sutures." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:12:22Z" ; oboInOwl:hasDbXref "UMLS:C4021163" ; oboInOwl:hasExactSynonym "Bilateral lambdoid craniosynostosis", "Bilateral lambdoid suture synostosis" ; oboInOwl:id "HP:0011319" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bilambdoid synostosis" ; rdfs:subClassOf obo:HP_0004443 . obo:HP_0011320 obo:IAO_0000115 "Premature synostosis of only one lambdoid suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:13:20Z" ; oboInOwl:hasDbXref "UMLS:C4021162" ; oboInOwl:hasExactSynonym "Unilateral lambdoid craniosynostosis", "Unilateral lambdoid suture synostosis" ; oboInOwl:id "HP:0011320" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Unilambdoid synostosis" ; rdfs:subClassOf obo:HP_0004443 . obo:HP_0011321 obo:IAO_0000115 "Premature synostosis of only the left lambdoid suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:13:46Z" ; oboInOwl:hasDbXref "UMLS:C4023415" ; oboInOwl:id "HP:0011321" ; a owl:Class ; rdfs:label "Left unilambdoid synostosis" ; rdfs:subClassOf obo:HP_0011320 . obo:HP_0011322 obo:IAO_0000115 "Premature synostosis of only the right lambdoid suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:14:34Z" ; oboInOwl:hasDbXref "UMLS:C4023414" ; oboInOwl:id "HP:0011322" ; a owl:Class ; rdfs:label "Right unilambdoid synostosis" ; rdfs:subClassOf obo:HP_0011320 . obo:HP_0011323 obo:IAO_0000115 "Incomplete fusion of the chin, resulting from a developmental defect and manifesting as a midline cleft or fissure of the chin." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:17:03Z" ; oboInOwl:hasDbXref "UMLS:C1849227" ; oboInOwl:hasExactSynonym "Cleft of chin", "Midline defect of chin" ; oboInOwl:id "HP:0011323" ; a owl:Class ; rdfs:label "Cleft of chin" ; rdfs:subClassOf obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011324 obo:IAO_0000115 "Craniosynostosis involving at least 2 cranial sutures, where the exact pattern of sutures fused has not been precisely specified." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:16:13Z" ; oboInOwl:hasDbXref "UMLS:C4021161" ; oboInOwl:hasExactSynonym "Multisutural craniosynostosis" ; oboInOwl:id "HP:0011324" ; a owl:Class ; rdfs:comment "If possible, it is preferable to annotate the precise pattern of involvement of the cranial sutures involved in craniosynostosis. This term may be chosen if more information is not available." ; rdfs:label "Multiple suture craniosynostosis" ; rdfs:subClassOf obo:HP_0001363 . obo:HP_0011325 obo:IAO_0000115 "Craniosynostosis of all calvarial sutures." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T01:27:38Z" ; oboInOwl:hasDbXref "UMLS:C4021827" ; oboInOwl:hasExactSynonym "Sysnostosis of all cranial sutures" ; oboInOwl:id "HP:0011325" ; a owl:Class ; rdfs:label "Pansynostosis" ; rdfs:subClassOf obo:HP_0011324 . obo:HP_0011326 obo:IAO_0000115 "Asymmetry of the anterior part of the skull." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T02:10:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:254020001", "UMLS:C0432124", "UMLS:C4023413", "UMLS:C4280328", "UMLS:C4280329", "UMLS:C4280330" ; oboInOwl:hasExactSynonym "Anterior flat head syndrome", "Deformational frontal plagiocephaly", "Frontal plagiocephaly" ; oboInOwl:hasNarrowSynonym "Deformational anterior plagiocephaly", "Positional anterior plagiocephaly", "Positional frontal plagiocephaly" ; oboInOwl:hasRelatedSynonym "Coronal synostosis", "Unicoronal craniosynostosis" ; oboInOwl:id "HP:0011326" ; a owl:Class ; rdfs:comment "Anterior plagiocephaly may have synostotic or non-synostotic causes." ; rdfs:label "Anterior plagiocephaly" ; rdfs:subClassOf obo:HP_0001357 . obo:HP_0011327 obo:IAO_0000115 "Asymmetry of the posterior part of the skull." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T02:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4021160" ; oboInOwl:hasExactSynonym "Deformational posterior plagiocephaly", "Occipital plagiocephaly" ; oboInOwl:id "HP:0011327" ; a owl:Class ; rdfs:comment "Anterior plagiocephaly may have synostotic or non-synostotic causes." ; rdfs:label "Posterior plagiocephaly" ; rdfs:subClassOf obo:HP_0001357 . obo:HP_0011328 obo:IAO_0000115 "An abnormality of the fontanelle." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T02:34:36Z" ; oboInOwl:hasDbXref "UMLS:C4020755" ; oboInOwl:hasRelatedSynonym "Anomaly of the fontanelles" ; oboInOwl:id "HP:0011328" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The fontanelles are the regions in an infant's calvaria that are covered by a thick membrane that normally ossify in the first two years of life." ; rdfs:label "Abnormality of fontanelles" ; rdfs:subClassOf obo:HP_0000235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011329 obo:IAO_0000115 "Any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T03:33:56Z" ; oboInOwl:hasDbXref "UMLS:C4023412" ; oboInOwl:hasExactSynonym "Abnormality of cranial sutures", "Abnormality of the bregma sutures", "Abnormality of the calvarium sutures", "Abnormality of the cranial sutures", "Abnormality of the skull suture" ; oboInOwl:id "HP:0011329" ; a owl:Class ; rdfs:label "Abnormality of cranial sutures" ; rdfs:subClassOf obo:HP_0000235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003685 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011330 obo:IAO_0000115 "Premature fusion of the metopic suture." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T03:52:01Z" ; oboInOwl:hasDbXref "MSH:C562951", "MSH:D003398", "SNOMEDCT_US:109409003", "UMLS:C0432122", "UMLS:C1860819" ; oboInOwl:hasExactSynonym "Metopic craniosynostosis", "Metopic suture craniosynostosis" ; oboInOwl:id "HP:0011330" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Metopic synostosis" ; rdfs:subClassOf obo:HP_0005556 . obo:HP_0011331 obo:IAO_0000115 "Unilateral atrophy of facial tissues, including muscles, bones and skin." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:04:56Z" ; oboInOwl:hasDbXref "MSH:D005150", "SNOMEDCT_US:718224004", "SNOMEDCT_US:95834000", "UMLS:C0015458" ; oboInOwl:hasExactSynonym "Atrophy of half of face", "Atrophy of one side of the face", "Facial hemiatrophy" ; oboInOwl:id "HP:0011331" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hemifacial atrophy" ; rdfs:subClassOf obo:HP_0000324 . obo:HP_0011332 obo:IAO_0000115 "Unilateral underdevelopment of the facial tissues, including muscles and bones." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:05:45Z" ; oboInOwl:hasDbXref "MSH:D006053", "SNOMEDCT_US:254025006", "UMLS:C3495417", "UMLS:C4023411" ; oboInOwl:hasExactSynonym "Decrease in size of half of face", "Decrease in size of one side of the face", "Decreased size of half of the face", "Decreased size of one side of the face", "Shrinking of half of face", "Shrinking of one side of the face" ; oboInOwl:hasRelatedSynonym "Hemifacial microsomia" ; oboInOwl:id "HP:0011332" ; a owl:Class ; rdfs:label "Hemifacial hypoplasia" ; rdfs:subClassOf obo:HP_0000324 . obo:HP_0011333 obo:IAO_0000115 "Asymmetry observed in the face of a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:07:01Z" ; oboInOwl:hasDbXref "MSH:C535349", "SNOMEDCT_US:51409009", "UMLS:C0431406", "UMLS:C4280327" ; oboInOwl:hasExactSynonym "Asymmetric crying face", "Partial unilateral facial paresis" ; oboInOwl:hasRelatedSynonym "Hypoplasia of depressor angula oris muscle" ; oboInOwl:id "HP:0011333" ; a owl:Class ; rdfs:comment "Asymmetric crying facies is caused by underdevelopment of the depressor anguli oris muscle or compression of one of the branches of the facial nerve." ; rdfs:label "Asymmetric crying face" ; rdfs:subClassOf obo:HP_0000324 . obo:HP_0011334 dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:10:19Z" ; oboInOwl:hasDbXref "UMLS:C4021159" ; oboInOwl:hasExactSynonym "Facial shape compression", "Facial shape deformation" ; oboInOwl:hasNarrowSynonym "Distortion of facial shape" ; oboInOwl:id "HP:0011334" ; a owl:Class ; rdfs:label "Facial shape deformation" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0011335 obo:IAO_0000115 "Excessive amount of hair growth on forehead." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:21:59Z" ; oboInOwl:hasDbXref "UMLS:C1839830" ; oboInOwl:hasExactSynonym "Hairy forehead", "Hirsute forehead" ; oboInOwl:id "HP:0011335" ; a owl:Class ; rdfs:label "Frontal hirsutism" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0009937 . obo:HP_0011336 obo:IAO_0000115 "Bilateral temporal scarlike defects, which are said to resemble forceps marks." ; dcterms:creator ; oboInOwl:creation_date "2012-02-25T05:25:36Z" ; oboInOwl:hasDbXref "UMLS:C4020754", "UMLS:C4023409" ; oboInOwl:hasExactSynonym "Bitemporal aplasia cutis congenita", "Congenital ectodermal dysplasia of the face", "Congenital, bilateral, scarlike facial lesions" ; oboInOwl:hasRelatedSynonym "Focal facial dermal dysplasia", "Temporal skin defect" ; oboInOwl:id "HP:0011336" ; a owl:Class ; rdfs:comment "Congenital, bilateral, scarlike facial lesions have been reported under several titles, such as hereditary symmetric systemic aplastic nevi, congenital ectodermal dysplasia of the face, familial focal facial dermal dysplasia, bitemporal aplasia cutis congenita, and focal facial dermal dysplasia (FFDD). The findings are congenital, bilateral scarlike facial lesions in the preauricular or cheek areas. The lesions may present as slightly depressed hypopigmented scarlike oval plaques measuring about 1 cm and may have a surrounding rim of fine lanugo-like hair. Skin biopsy can reveal an atrophic epidermis with a thinned dermis devoid of adnexal structures. Elastic fibers are absent in the affected areas, as can be shown by Verhoeff-van Giesen staining." ; rdfs:label "Bitemporal forceps marks" ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0011337 dcterms:creator ; oboInOwl:creation_date "2012-02-26T11:00:17Z" ; oboInOwl:hasDbXref "UMLS:C4023408" ; oboInOwl:hasExactSynonym "Abnormality of mouth size", "Anomaly of mouth size" ; oboInOwl:id "HP:0011337" ; a owl:Class ; rdfs:label "Abnormality of mouth size" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011338 obo:IAO_0000115 "An abnormality of the outline, configuration, or contour of the mouth." ; dcterms:creator ; oboInOwl:creation_date "2012-02-26T01:05:23Z" ; oboInOwl:hasDbXref "Fyler:4874", "UMLS:C4023407" ; oboInOwl:hasExactSynonym "Abnormality of mouth shape", "Anomaly of mouth shape" ; oboInOwl:hasNarrowSynonym "Unusual mouth shape" ; oboInOwl:id "HP:0011338" ; a owl:Class ; rdfs:label "Abnormality of mouth shape" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011339 obo:IAO_0000115 "An abnormality of the vermilion border, the sharp demarcation between the lip (red colored) and the adjacent normal skin." ; dcterms:creator ; oboInOwl:creation_date "2012-02-26T01:32:28Z" ; oboInOwl:hasDbXref "UMLS:C4023406" ; oboInOwl:hasNarrowSynonym "Abnormality of the red part of the upper lip", "Anomaly of the upper lip vermillion", "Deformity of the upper lip vermillion", "Malformation of the upper lip vermillion" ; oboInOwl:id "HP:0011339" ; a owl:Class ; rdfs:label "Abnormality of upper lip vermillion" ; rdfs:subClassOf obo:HP_0000177 . obo:HP_0011340 obo:IAO_0000115 "A subtle unilateral cleft of the upper lip, which may appear as a small indentation." ; dcterms:creator ; oboInOwl:creation_date "2012-02-26T01:55:36Z" ; oboInOwl:hasDbXref "UMLS:C4021158" ; oboInOwl:hasExactSynonym "Forme fruste unilateral cleft lip", "Incomplete cheiloschisis", "Incomplete cleft of the upper lip", "Notched cleft of the upper lip", "Partial cleft of the upper lip" ; oboInOwl:id "HP:0011340" ; a owl:Class ; rdfs:comment "If the cleft lip is on only one side, use 'Incomplete unilateral cleft lip' (HP:5201000)." ; rdfs:label "Incomplete cleft of the upper lip" ; rdfs:subClassOf obo:HP_0000204 . obo:HP_0011341 obo:IAO_0000115 "Increased width of the upper lip." ; dcterms:creator ; oboInOwl:creation_date "2012-02-26T01:58:08Z" ; oboInOwl:hasDbXref "UMLS:C3151495" ; oboInOwl:hasExactSynonym "Elongation of upper lip", "Increased height of upper lip", "Increased vertical length of upper lip", "Long upper lip" ; oboInOwl:id "HP:0011341" ; a owl:Class ; rdfs:label "Long upper lip" ; rdfs:subClassOf obo:HP_0000177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011342 obo:IAO_0000115 "A mild delay in the achievement of motor or mental milestones in the domains of development of a child." ; dcterms:creator ; oboInOwl:creation_date "2012-02-29T11:19:49Z" ; oboInOwl:hasDbXref "UMLS:C2229182", "UMLS:C4012968" ; oboInOwl:hasExactSynonym "Global developmental delay, mild" ; oboInOwl:hasRelatedSynonym "Psychomotor retardation, mild" ; oboInOwl:id "HP:0011342" ; a owl:Class ; rdfs:label "Mild global developmental delay" ; rdfs:subClassOf obo:HP_0001263 . obo:HP_0011343 obo:IAO_0000115 "A moderate delay in the achievement of motor or mental milestones in the domains of development of a child." ; dcterms:creator ; oboInOwl:creation_date "2012-02-29T11:20:28Z" ; oboInOwl:hasDbXref "UMLS:C2237142" ; oboInOwl:hasExactSynonym "Global developmental delay, moderate" ; oboInOwl:hasRelatedSynonym "Psychomotor retardation, moderate" ; oboInOwl:id "HP:0011343" ; a owl:Class ; rdfs:label "Moderate global developmental delay" ; rdfs:subClassOf obo:HP_0001263 . obo:HP_0011344 obo:IAO_0000115 "A severe delay in the achievement of motor or mental milestones in the domains of development of a child." ; dcterms:creator ; oboInOwl:creation_date "2012-02-29T11:20:45Z" ; oboInOwl:hasDbXref "UMLS:C1837397", "UMLS:C1854919" ; oboInOwl:hasExactSynonym "Global developmental delay, severe" ; oboInOwl:hasRelatedSynonym "Severe psychomotor retardation" ; oboInOwl:id "HP:0011344" ; a owl:Class ; rdfs:label "Severe global developmental delay" ; rdfs:subClassOf obo:HP_0001263 . obo:HP_0011345 obo:IAO_0000115 "A moderate delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T08:45:49Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:62211000119103", "UMLS:C3532933" ; oboInOwl:id "HP:0011345" ; a owl:Class ; rdfs:label "Moderate expressive language delay" ; rdfs:subClassOf obo:HP_0002474 . obo:HP_0011346 obo:IAO_0000115 "A mild delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T08:46:23Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:62231000119108", "UMLS:C3532934" ; oboInOwl:id "HP:0011346" ; a owl:Class ; rdfs:label "Mild expressive language delay" ; rdfs:subClassOf obo:HP_0002474 . obo:HP_0011347 obo:IAO_0000115 "An abnormality involving the movement of the eye outwards." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:18:05Z" ; oboInOwl:hasDbXref "UMLS:C4023405" ; oboInOwl:id "HP:0011347" ; a owl:Class ; rdfs:label "Abnormality of ocular abduction" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0011348 obo:IAO_0000115 "Any structural abnormality of the abducens nerve." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:20:44Z" ; oboInOwl:hasDbXref "UMLS:C4023404" ; oboInOwl:hasExactSynonym "Abnormal abducens nerve morphology", "Abnormality of the sixth cranial nerve" ; oboInOwl:id "HP:0011348" ; a owl:Class ; rdfs:comment "The abducens nerve (also known as the sixth cranial nerve or cranioal nerve VI) controls the movement of the lateral rectus muscle of the eye, which moves the eyeball in the outward direction (towards the side of the head)." ; rdfs:label "Abnormal sixth cranial nerve morphology" ; rdfs:subClassOf obo:HP_0001291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011349 obo:IAO_0100001 "HP:0006897" ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:30:20Z" ; oboInOwl:id "HP:0011349" ; a owl:Class ; rdfs:label "obsolete Abducens palsy" ; owl:deprecated true . obo:HP_0011350 obo:IAO_0000115 "A mild delay in the acquisition of the ability to understand the speech of others." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:52:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89501000119108", "UMLS:C3532948" ; oboInOwl:id "HP:0011350" ; a owl:Class ; rdfs:label "Mild receptive language delay" ; rdfs:subClassOf obo:HP_0010863 . obo:HP_0011351 obo:IAO_0000115 "A moderate delay in the acquisition of the ability to understand the speech of others." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:53:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89381000119107", "UMLS:C3532946" ; oboInOwl:id "HP:0011351" ; a owl:Class ; rdfs:label "Moderate receptive language delay" ; rdfs:subClassOf obo:HP_0010863 . obo:HP_0011352 obo:IAO_0000115 "A severe delay in the acquisition of the ability to understand the speech of others." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T10:53:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89391000119105", "UMLS:C3532947" ; oboInOwl:id "HP:0011352" ; a owl:Class ; rdfs:label "Severe receptive language delay" ; rdfs:subClassOf obo:HP_0010863 . obo:HP_0011353 obo:IAO_0000115 "Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T01:05:59Z" ; oboInOwl:hasDbXref "UMLS:C4020753", "UMLS:C4023403" ; oboInOwl:hasRelatedSynonym "Intimal fibrosis" ; oboInOwl:id "HP:0011353" ; a owl:Class ; rdfs:label "Arterial intimal fibrosis" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0011354 obo:IAO_0000115 "An abnormality of the skin that is not localized to any one particular region." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T01:55:07Z" ; oboInOwl:hasDbXref "UMLS:C4021157" ; oboInOwl:hasExactSynonym "Generalised abnormality of skin", "Generalized abnormality of skin" ; oboInOwl:id "HP:0011354" ; a owl:Class ; rdfs:label "Generalized abnormality of skin" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0011355 obo:IAO_0000115 "A lesion of the skin that is located in a specific region rather than being generalized." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T02:37:43Z" ; oboInOwl:hasDbXref "UMLS:C0850826" ; oboInOwl:hasExactSynonym "Localised skin lesion", "Localized skin lesion" ; oboInOwl:id "HP:0011355" ; a owl:Class ; rdfs:label "Localized skin lesion" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0011356 obo:IAO_0000115 "An abnormality of the skin that is restricted to a particular body region." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T02:39:14Z" ; oboInOwl:hasDbXref "UMLS:C4023402" ; oboInOwl:id "HP:0011356" ; a owl:Class ; rdfs:label "Regional abnormality of skin" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0011357 obo:IAO_0100001 "HP:0011362" ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T02:51:40Z" ; oboInOwl:id "HP:0011357" ; a owl:Class ; rdfs:label "obsolete Abnormality of hair density" ; owl:deprecated true . obo:HP_0011358 obo:IAO_0000115 "Reduced pigmentation of hair diffusely." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T03:32:59Z" ; oboInOwl:hasDbXref "UMLS:C4023400" ; oboInOwl:hasExactSynonym "Generalised hypopigmentation of hair" ; oboInOwl:id "HP:0011358" ; a owl:Class ; rdfs:label "Generalized hypopigmentation of hair" ; rdfs:subClassOf obo:HP_0005599 . obo:HP_0011359 obo:IAO_0000115 "Hair that lacks the lustre (shine or gleam) of normal hair." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T04:24:09Z" ; oboInOwl:hasAlternativeId "HP:0200077", "HP:0200079", "HP:0200080" ; oboInOwl:hasDbXref "SNOMEDCT_US:79395009", "UMLS:C0277960" ; oboInOwl:hasExactSynonym "Dry hair" ; oboInOwl:id "HP:0011359" ; a owl:Class ; rdfs:label "Dry hair" ; rdfs:subClassOf obo:HP_0010719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001824 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011360 obo:IAO_0000115 "An abnormality of the distribution of hair growth that is acquired during the course of life." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T08:36:23Z" ; oboInOwl:hasDbXref "UMLS:C4023399" ; oboInOwl:hasExactSynonym "Acquired abnormal hair pattern" ; oboInOwl:id "HP:0011360" ; a owl:Class ; rdfs:label "Acquired abnormal hair pattern" ; rdfs:subClassOf obo:HP_0010720 . obo:HP_0011361 obo:IAO_0000115 "A congenital abnormality of the distribution of hair growth." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T08:39:51Z" ; oboInOwl:hasDbXref "UMLS:C4023398" ; oboInOwl:hasExactSynonym "Abnormal hair pattern since birth" ; oboInOwl:id "HP:0011361" ; a owl:Class ; rdfs:label "Congenital abnormal hair pattern" ; rdfs:subClassOf obo:HP_0010720 . obo:HP_0011362 obo:IAO_0000115 "An abnormal amount of hair." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T08:46:57Z" ; oboInOwl:hasAlternativeId "HP:0002115", "HP:0011357" ; oboInOwl:hasDbXref "UMLS:C4023397", "UMLS:C4023401" ; oboInOwl:hasExactSynonym "Abnormal hair quantity", "Abnormality of hair density" ; oboInOwl:id "HP:0011362" ; a owl:Class ; rdfs:label "Abnormal hair quantity" ; rdfs:subClassOf obo:HP_0001595 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011363 obo:IAO_0000115 "Hair whose growth rate deviates from the norm." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T09:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4023396" ; oboInOwl:hasExactSynonym "Abnormality of hair growth rate", "Abnormality of pace of hair growth", "Abnormality of speed of hair growth" ; oboInOwl:id "HP:0011363" ; a owl:Class ; rdfs:comment "Hair growth rate is normally about 1.25 centimeters per month." ; rdfs:label "Abnormality of hair growth rate" ; rdfs:subClassOf obo:HP_0040170 . obo:HP_0011364 obo:IAO_0000115 "Hypopigmented hair that appears white." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T09:50:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:297993006", "UMLS:C0239804" ; oboInOwl:hasExactSynonym "White hair" ; oboInOwl:id "HP:0011364" ; a owl:Class ; rdfs:label "White hair" ; rdfs:subClassOf obo:HP_0011358 . obo:HP_0011365 obo:IAO_0000115 "Reduced pigmentation of hair in patches." ; dcterms:creator ; oboInOwl:creation_date "2012-03-01T09:52:58Z" ; oboInOwl:hasDbXref "UMLS:C4023395" ; oboInOwl:id "HP:0011365" ; a owl:Class ; rdfs:label "Patchy hypopigmentation of hair" ; rdfs:subClassOf obo:HP_0005599 . obo:HP_0011367 obo:IAO_0000115 "Yellowish discoloration of the nails." ; dcterms:creator ; oboInOwl:creation_date "2012-03-03T12:08:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:45342007", "UMLS:C1768507" ; oboInOwl:hasExactSynonym "Yellow nails" ; oboInOwl:id "HP:0011367" ; a owl:Class ; rdfs:label "Yellow nails" ; rdfs:subClassOf obo:HP_0100643 . obo:HP_0011368 obo:IAO_0000115 "Thickening of the epidermal layer of the skin." ; dcterms:creator ; oboInOwl:creation_date "2012-03-03T12:25:18Z" ; oboInOwl:hasAlternativeId "HP:0001035" ; oboInOwl:hasDbXref "UMLS:C0494876", "UMLS:C4020752" ; oboInOwl:hasRelatedSynonym "Abnormality of keratinization" ; oboInOwl:id "HP:0011368" ; a owl:Class ; rdfs:label "Epidermal thickening" ; rdfs:subClassOf obo:HP_0001072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0031424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011369 obo:IAO_0000115 "Congenital deep dermal melanosis in the sacral area." ; dcterms:creator ; oboInOwl:creation_date "2012-03-03T03:34:48Z" ; oboInOwl:hasDbXref "MSH:D049328", "SNOMEDCT_US:40467008", "UMLS:C0265985" ; oboInOwl:id "HP:0011369" ; a owl:Class ; rdfs:label "Mongolian blue spot" ; rdfs:subClassOf obo:HP_0001034 . obo:HP_0011370 obo:IAO_0000115 "Increased susceptibility to cutaneous fungal infections, as manifested by recurrent episodes of cutaneous fungal infections." ; dcterms:creator ; oboInOwl:creation_date "2012-03-03T10:34:52Z" ; oboInOwl:hasDbXref "UMLS:C4023394" ; oboInOwl:id "HP:0011370" ; a owl:Class ; rdfs:label "Recurrent cutaneous fungal infections" ; rdfs:subClassOf obo:HP_0001581, obo:HP_0002841 . obo:HP_0011371 obo:IAO_0000115 "Increased susceptibility to viral skin infections, as manifested by recurrent episodes of viral skin infections." ; dcterms:creator ; oboInOwl:creation_date "2012-03-03T10:36:20Z" ; oboInOwl:hasDbXref "UMLS:C4023393" ; oboInOwl:hasExactSynonym "Recurrent viral skin infections" ; oboInOwl:id "HP:0011371" ; a owl:Class ; rdfs:label "Recurrent viral skin infections" ; rdfs:subClassOf obo:HP_0001581, obo:HP_0004429 . obo:HP_0011372 obo:IAO_0000115 "Absence of the inner ear due to a developmental defect." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:23:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:71973003", "UMLS:C0266604" ; oboInOwl:hasExactSynonym "Absent inner ear", "Aplasia of the labyrinth", "Labyrinthine aplasia", "Michel deformity" ; oboInOwl:id "HP:0011372" ; a owl:Class ; rdfs:comment "Aplasia of the inner ear is usually diagnosed on MR or CT imaging." ; rdfs:label "Aplasia of the inner ear" ; rdfs:subClassOf obo:HP_0008774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001846 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011373 obo:IAO_0000115 "Incomplete formation of the cochlear partition. The scala vestibuli and scala tympani separated by the cochlear partition, except in the apical turn where the two scalae are in continuity via the helicotrema." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:24:55Z" ; oboInOwl:hasDbXref "UMLS:C4023392" ; oboInOwl:id "HP:0011373" ; a owl:Class ; rdfs:label "Incomplete partition of the cochlea" ; rdfs:subClassOf obo:HP_0008554 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001796 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011374 obo:IAO_0000115 "Incomplete partition I is also known as cystic cochleovestibular malformation, where the cochlea has no bony modiolus, resulting in an empty cystic cochlea. This is accompanied by a dilated cystic vestibule with developmental arrest at the fifth week of gestation." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:26:25Z" ; oboInOwl:hasDbXref "UMLS:C4023391" ; oboInOwl:id "HP:0011374" ; a owl:Class ; rdfs:label "Incomplete partition of the cochlea type I" ; rdfs:subClassOf obo:HP_0011373 . obo:HP_0011375 obo:IAO_0000115 "Absence of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:31:27Z" ; oboInOwl:hasDbXref "UMLS:C4023390" ; oboInOwl:hasExactSynonym "Absent cochlea" ; oboInOwl:id "HP:0011375" ; a owl:Class ; rdfs:label "Cochlear aplasia" ; rdfs:subClassOf obo:HP_0011395 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011376 obo:IAO_0000115 "A morphological abnormality of the vestibule, the central part of the osseous labyrinth that is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:35:08Z" ; oboInOwl:hasDbXref "UMLS:C0542259" ; oboInOwl:hasExactSynonym "Vestibular abnormality" ; oboInOwl:id "HP:0011376" ; a owl:Class ; rdfs:comment """The vestibular system consists of five distinct components, three semicircular canals that are sensitive to angular acceleration and two otolith organs that are sensitive to linear acceleration.""" ; rdfs:label "Morphological abnormality of the vestibule of the inner ear" ; rdfs:subClassOf obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011377 obo:IAO_0000115 "Complete absence of the vestibule of the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-07T08:37:27Z" ; oboInOwl:hasDbXref "UMLS:C4023389" ; oboInOwl:hasExactSynonym "Absent vestibule" ; oboInOwl:id "HP:0011377" ; a owl:Class ; rdfs:label "Aplasia of the vestibule" ; rdfs:subClassOf obo:HP_0011376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011378 obo:IAO_0000115 "Underdevelopment of the vestibule of the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:06:20Z" ; oboInOwl:hasDbXref "UMLS:C4023388" ; oboInOwl:id "HP:0011378" ; a owl:Class ; rdfs:label "Hypoplasia of the vestibule of the inner ear" ; rdfs:subClassOf obo:HP_0011376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011379 obo:IAO_0000115 "Dilatation of the vestibule of the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:07:38Z" ; oboInOwl:hasDbXref "UMLS:C4023387" ; oboInOwl:id "HP:0011379" ; a owl:Class ; rdfs:label "Dilated vestibule of the inner ear" ; rdfs:subClassOf obo:HP_0011376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011380 obo:IAO_0000115 "An abnormality of the morphology of the semicircular canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:12:21Z" ; oboInOwl:hasDbXref "UMLS:C4023386" ; oboInOwl:id "HP:0011380" ; a owl:Class ; rdfs:label "Morphological abnormality of the semicircular canal" ; rdfs:subClassOf obo:HP_0011376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011381 obo:IAO_0000115 "Absence of the semicircular canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:14:57Z" ; oboInOwl:hasDbXref "UMLS:C4023385" ; oboInOwl:hasExactSynonym "Absent semicircular canal" ; oboInOwl:id "HP:0011381" ; a owl:Class ; rdfs:label "Aplasia of the semicircular canal" ; rdfs:subClassOf obo:HP_0011380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011382 obo:IAO_0000115 "Underdevelopment of the semicircular canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:15:47Z" ; oboInOwl:hasDbXref "UMLS:C3552156" ; oboInOwl:hasExactSynonym "Small semicircular canal" ; oboInOwl:hasRelatedSynonym "Hypoplasia of the semicircular canals" ; oboInOwl:id "HP:0011382" ; a owl:Class ; rdfs:label "Hypoplasia of the semicircular canal" ; rdfs:subClassOf obo:HP_0011380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011383 obo:IAO_0000115 "Increased size of the semicircular canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:16:58Z" ; oboInOwl:hasDbXref "UMLS:C4021156" ; oboInOwl:hasExactSynonym "Dilated semicircular canal" ; oboInOwl:id "HP:0011383" ; a owl:Class ; rdfs:label "Enlarged semicircular canal" ; rdfs:subClassOf obo:HP_0011380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011384 obo:IAO_0000115 "An abnormality of the Internal acoustic meatus, i.e., of the canal in the petrous part of the temporal bone through which the cranial nerve VII and cranial nerve VIII traverse." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:26:47Z" ; oboInOwl:hasDbXref "UMLS:C4021155" ; oboInOwl:hasExactSynonym "Abnormality of the internal acoustic meatus" ; oboInOwl:id "HP:0011384" ; a owl:Class ; rdfs:label "Abnormality of the internal auditory canal" ; rdfs:subClassOf obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011859 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011385 obo:IAO_0000115 "Aplasia of the internal auditory canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:33:46Z" ; oboInOwl:hasDbXref "UMLS:C4023384" ; oboInOwl:id "HP:0011385" ; a owl:Class ; rdfs:label "Absent internal auditory canal" ; rdfs:subClassOf obo:HP_0011384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011859 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011386 obo:IAO_0000115 "Reduction in diameter of the internal auditory canal." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:35:00Z" ; oboInOwl:hasDbXref "UMLS:C4023383" ; oboInOwl:id "HP:0011386" ; a owl:Class ; rdfs:label "Narrow internal auditory canal" ; rdfs:subClassOf obo:HP_0011384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001899 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011859 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011387 obo:IAO_0000115 "Increased size of the vestibular aqueduct." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:38:34Z" ; oboInOwl:hasDbXref "MSH:C566366", "UMLS:C1863752" ; oboInOwl:hasExactSynonym "Dilated vestibular aqueduct", "Widened vestibular aqueduct" ; oboInOwl:id "HP:0011387" ; a owl:Class ; rdfs:comment "Enlarged vestibular aqueduct is commonly seen in Pendred syndrome." ; rdfs:label "Enlarged vestibular aqueduct" ; rdfs:subClassOf obo:HP_0011376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002279 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011388 obo:IAO_0000115 "Increased size of the cochlear duct, i.e., of a duct that communicates between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T07:41:47Z" ; oboInOwl:hasDbXref "UMLS:C4021154" ; oboInOwl:hasExactSynonym "Dilated cochlear aqueduct" ; oboInOwl:id "HP:0011388" ; a owl:Class ; rdfs:comment "The cochlear aqueduct surrounds the perilymphatic (periotic duct). Enlargement of the cochlear aqueduct may be seen in POU3F4 X-linked deafness with Gusher." ; rdfs:label "Enlarged cochlear aqueduct" ; rdfs:subClassOf obo:HP_0000375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001855 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011389 obo:IAO_0000115 "An abnormality of the function of the inner ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T04:58:30Z" ; oboInOwl:hasDbXref "UMLS:C4023382" ; oboInOwl:hasExactSynonym "Functional abnormality of the inner ear" ; oboInOwl:id "HP:0011389" ; a owl:Class ; rdfs:comment "The inner ear comprises the cochlea, three semicircular canals and the vestibule (labyrinth), and is directly responsible for hearing. Additionally, the vestibule and semicircular canals function to maintain balance or equilibrium." ; rdfs:label "Functional abnormality of the inner ear" ; rdfs:subClassOf obo:HP_0031704 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001846 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011390 obo:IAO_0000115 "A structural anomaly of the internal part of the ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T04:59:24Z" ; oboInOwl:hasDbXref "UMLS:C4023381" ; oboInOwl:id "HP:0011390" ; a owl:Class ; rdfs:comment "The inner ear contains the cochlea and the semicircular canals." ; rdfs:label "Morphological abnormality of the inner ear" ; rdfs:subClassOf obo:HP_0000359 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001846 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011391 dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:03:30Z" ; oboInOwl:hasDbXref "UMLS:C4023380" ; oboInOwl:id "HP:0011391" ; a owl:Class ; rdfs:label "Morphological abnormality of the nerves of the inner ear" ; rdfs:subClassOf obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011392 dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:03:47Z" ; oboInOwl:hasDbXref "UMLS:C4023379" ; oboInOwl:id "HP:0011392" ; a owl:Class ; rdfs:label "Abnormality of the vestibular nerve" ; rdfs:subClassOf obo:HP_0011391 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011393 obo:IAO_0000115 "Absence of the vestibular nerve" ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:08:14Z" ; oboInOwl:hasDbXref "UMLS:C4020751", "UMLS:C4021153" ; oboInOwl:hasExactSynonym "Absent cranial nerve viii", "Absent the eighth cranial nerve", "Absent vestribular nerve", "Aplasia of the eighth cranial nerve" ; oboInOwl:hasRelatedSynonym "Aplasia of cranial nerve VIII" ; oboInOwl:id "HP:0011393" ; a owl:Class ; rdfs:comment "May be seen in CHARGE syndrome." ; rdfs:label "Aplasia of the vestibular nerve." ; rdfs:subClassOf obo:HP_0011392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011394 obo:IAO_0000115 "Underdevelopment of the vestibular nerve." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:14:35Z" ; oboInOwl:hasDbXref "UMLS:C4020750" ; oboInOwl:hasExactSynonym "Hypoplasia of the eighth cranial nerve", "Thin vestibular nerve" ; oboInOwl:hasRelatedSynonym "Hypoplasia of cranial nerve VIII" ; oboInOwl:id "HP:0011394" ; a owl:Class ; rdfs:label "Hypoplasia of the vestibular nerve" ; rdfs:subClassOf obo:HP_0011392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011395 obo:IAO_0000115 "Absence or underdevelopment of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:37:50Z" ; oboInOwl:hasDbXref "UMLS:C4023378" ; oboInOwl:hasExactSynonym "Absent/small cochlea", "Absent/underdeveloped cochlea" ; oboInOwl:id "HP:0011395" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cochlea" ; rdfs:subClassOf obo:HP_0000375, obo:HP_0008774 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011396 obo:IAO_0000115 "Any anomaly of the cohclear nerve, which is the part of the vestibulocochlear nerve that is responsible for transmitting auditory signals from the inner ear to the cochlear nuclei within the brainstem and ultimately to the primary auditory cortex within the temporal lobe." ; dcterms:creator ; oboInOwl:creation_date "2012-03-09T05:39:04Z" ; oboInOwl:hasDbXref "UMLS:C4023377" ; oboInOwl:id "HP:0011396" ; a owl:Class ; rdfs:label "Abnormality of the cochlear nerve" ; rdfs:subClassOf obo:HP_0011391 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004727 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011397 obo:IAO_0000115 "An abnormality of the dorsal columns, i.e., of the dorsal portion of the gray substance of the spinal cord. The dorsal column consists of the fasciculus gracilis and fasciculus cuneatus and itself is part of the dorsal funiculus." ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T07:39:12Z" ; oboInOwl:hasDbXref "UMLS:C4023376" ; oboInOwl:id "HP:0011397" ; a owl:Class ; rdfs:comment "The dorsal column represents an ascending pathway mediating well-localized fine touch and conscious proprioception." ; rdfs:label "Abnormality of the dorsal column of the spinal cord" ; rdfs:subClassOf obo:HP_0002143 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005373 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011398 obo:IAO_0100001 "HP:0001252" ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T04:39:51Z" ; oboInOwl:id "HP:0011398" ; a owl:Class ; rdfs:label "obsolete Central hypotonia" ; owl:deprecated true . obo:HP_0011399 obo:IAO_0000115 "Wasting of the tibialis anterior muscle." ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T06:15:40Z" ; oboInOwl:hasDbXref "UMLS:C4023375" ; oboInOwl:hasExactSynonym "Sharp shin sign", "Tibialis anterior amyotrophy", "Tibialis muscle degeneration" ; oboInOwl:id "HP:0011399" ; a owl:Class ; rdfs:comment "The tibialis anterior muscle is located in the front of the lower leg. The shin may appear prominent because of atrophy of the tibialis anterior muscle (sharp shin sign)." ; rdfs:label "Tibialis anterior muscle atrophy" ; rdfs:subClassOf obo:HP_0008944 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011400 obo:IAO_0000115 "An abnormality of myelination of nerves in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T07:24:42Z" ; oboInOwl:hasAlternativeId "HP:0002520", "HP:0004335" ; oboInOwl:hasDbXref "UMLS:C4021152" ; oboInOwl:hasExactSynonym "Abnormal formation of myelin sheaths" ; oboInOwl:id "HP:0011400" ; a owl:Class ; rdfs:comment "In the CNS, myelin is the product of oligodendrocytes (and not of Schwann cells, as in the PNS). This term refers to an abnormality of the process in which myelin sheaths are formed and maintained around neurons or the result of such an abnormality." ; rdfs:label "Abnormal CNS myelination" ; rdfs:subClassOf obo:HP_0002011, obo:HP_0012447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0022010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011401 obo:IAO_0000115 "Delayed myelination in the peripheral nervous system." ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T08:08:41Z" ; oboInOwl:hasDbXref "UMLS:C4023374" ; oboInOwl:id "HP:0011401" ; a owl:Class ; rdfs:label "Delayed peripheral myelination" ; rdfs:subClassOf obo:HP_0003130, obo:HP_0012448 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0022011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011402 obo:IAO_0000115 "Demyelination of peripheral sensory nerves." ; dcterms:creator ; oboInOwl:creation_date "2012-03-12T08:28:12Z" ; oboInOwl:hasDbXref "UMLS:C4023373" ; oboInOwl:id "HP:0011402" ; a owl:Class ; rdfs:label "Demyelinating sensory neuropathy" ; rdfs:subClassOf obo:HP_0007108 . obo:HP_0011403 dcterms:creator ; oboInOwl:creation_date "2012-03-15T11:05:13Z" ; oboInOwl:hasDbXref "UMLS:C4023372" ; oboInOwl:hasExactSynonym "Abnormal umbilical cord blood vessels" ; oboInOwl:id "HP:0011403" ; a owl:Class ; rdfs:label "Abnormal umbilical cord blood vessel morphology" ; rdfs:subClassOf obo:HP_0010881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010260 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011404 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs that is lethal at birth." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:38:44Z" ; oboInOwl:hasDbXref "UMLS:C4021151" ; oboInOwl:hasExactSynonym "Lethal short-trunk dwarfism" ; oboInOwl:id "HP:0011404" ; a owl:Class ; rdfs:label "Lethal short-trunk short stature" ; rdfs:subClassOf obo:HP_0003521 . obo:HP_0011405 dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:44:56Z" ; oboInOwl:hasAlternativeId "HP:0003523" ; oboInOwl:hasDbXref "UMLS:C1867487" ; oboInOwl:hasExactSynonym "Short-limb dwarfism identifiable during childhood" ; oboInOwl:id "HP:0011405" ; a owl:Class ; rdfs:label "Childhood onset short-limb short stature" ; rdfs:subClassOf obo:HP_0008873 . obo:HP_0011406 obo:IAO_0000115 "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in infancy." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:45:48Z" ; oboInOwl:hasAlternativeId "HP:0008851" ; oboInOwl:hasDbXref "UMLS:C1846061" ; oboInOwl:hasExactSynonym "Short-trunk dwarfism, identifiable in infancy" ; oboInOwl:id "HP:0011406" ; a owl:Class ; rdfs:label "Infancy onset short-trunk short stature" ; rdfs:subClassOf obo:HP_0003521 . obo:HP_0011407 dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:47:20Z" ; oboInOwl:hasDbXref "UMLS:C4023371" ; oboInOwl:id "HP:0011407" ; a owl:Class ; rdfs:label "Proportionate tall stature" ; rdfs:subClassOf obo:HP_0000098 . obo:HP_0011408 obo:IAO_0000115 "Intrauterine growth retardation that is at least 3 standard deviations (SD) below average, but not as low as 4 SD, corrected for sex and gestational age." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:52:50Z" ; oboInOwl:hasDbXref "UMLS:C4023370" ; oboInOwl:id "HP:0011408" ; a owl:Class ; rdfs:label "Moderate intrauterine growth retardation" ; rdfs:subClassOf obo:HP_0001511 . obo:HP_0011409 obo:IAO_0000115 "Structural anomaly of the fetal membranes (also known as the amniochorionic or placental membranes), which comprise a vital intrauterine compartment, where they perform mechanical, immune, and endocrine functions to promote growth of the fetus and protection from environmental adversity. Amniochorionic membranes anatomically consist of a single layer of cuboidal amnion epithelial cells, chorionic trophoblasts, and scattered fibroblasts connected by a layer of type IV collagen-rich extracellular matrix." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T11:07:01Z" ; oboInOwl:hasDbXref "UMLS:C4023369" ; oboInOwl:hasExactSynonym "Abnormality of placental membranes" ; oboInOwl:id "HP:0011409" ; a owl:Class ; rdfs:label "Abnormal placental membrane morphology" ; rdfs:subClassOf obo:HP_0001194 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0009002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011410 obo:IAO_0000115 "Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:58:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:200144004", "UMLS:C1384674" ; oboInOwl:hasExactSynonym "Caesarian section" ; oboInOwl:id "HP:0011410" ; a owl:Class ; rdfs:label "Caesarian section" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0011411 dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:58:47Z" ; oboInOwl:hasDbXref "UMLS:C0341808" ; oboInOwl:hasExactSynonym "Forceps delivery" ; oboInOwl:id "HP:0011411" ; a owl:Class ; rdfs:label "Forceps delivery" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0011412 obo:IAO_0000115 "Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T09:59:31Z" ; oboInOwl:hasDbXref "MSH:D014620", "SNOMEDCT_US:10761101000119105", "SNOMEDCT_US:61586001", "UMLS:C0042225", "UMLS:C1456852", "UMLS:C2825567" ; oboInOwl:hasExactSynonym "Vacuum extraction", "Vacuum-assisted vaginal delivery" ; oboInOwl:id "HP:0011412" ; a owl:Class ; rdfs:label "Ventouse delivery" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0011413 obo:IAO_0000115 "Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:01:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89700002", "UMLS:C0269825" ; oboInOwl:id "HP:0011413" ; a owl:Class ; rdfs:comment "Adelivery in which additional maneuvers are required to deliver the fetus after normal gentle downward traction has failed." ; rdfs:label "Shoulder dystocia" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0011414 obo:IAO_0000115 "An abnormality of the placenta in which there are numerous cystic spaces within the placenta as well as placental enlargement." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:07:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:75094005", "UMLS:C0270254" ; oboInOwl:hasExactSynonym "Hydrops of the placenta" ; oboInOwl:id "HP:0011414" ; a owl:Class ; rdfs:label "Hydropic placenta" ; rdfs:subClassOf obo:HP_0006267 . obo:HP_0011415 dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:10:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249174002", "UMLS:C0426234" ; oboInOwl:hasExactSynonym "Placental calcification" ; oboInOwl:id "HP:0011415" ; a owl:Class ; rdfs:label "Calcified placenta" ; rdfs:subClassOf obo:HP_0100767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011416 dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:11:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:268585006", "UMLS:C0554393" ; oboInOwl:hasExactSynonym "Placental thromboembolism" ; oboInOwl:id "HP:0011416" ; a owl:Class ; rdfs:label "Placental infarction" ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0011417 obo:IAO_0000115 "Increased length of the umbilical cord." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:12:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237261008", "UMLS:C0405028" ; oboInOwl:hasExactSynonym "Long umbilical cord" ; oboInOwl:id "HP:0011417" ; a owl:Class ; rdfs:label "Long umbilical cord" ; rdfs:subClassOf obo:HP_0010881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002331 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011418 obo:IAO_0000115 "Anomalous location of the insertion of umbilical cord in the placenta. Normally, the insertion is at least two centimers distant from the edge of the placenta." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T10:15:01Z" ; oboInOwl:hasDbXref "MSH:D055949", "SNOMEDCT_US:79668009", "UMLS:C0269852" ; oboInOwl:id "HP:0011418" ; a owl:Class ; rdfs:label "Abnormal insertion of umbilical cord" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0011419 obo:IAO_0000115 "Separation of the placenta from the uterus wall before delivery." ; dcterms:creator ; oboInOwl:creation_date "2012-03-15T11:08:18Z" ; oboInOwl:hasDbXref "MSH:D000037", "SNOMEDCT_US:405736009", "SNOMEDCT_US:415105001", "UMLS:C0000832" ; oboInOwl:hasExactSynonym "Abruptio placentae" ; oboInOwl:id "HP:0011419" ; a owl:Class ; rdfs:label "Placental abruption" ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0011420 obo:IAO_0000115 "The age group when the cessation of life happens." ; oboInOwl:hasDbXref "UMLS:C1546180" ; oboInOwl:id "HP:0011420" ; a owl:Class ; rdfs:label "Age of death" ; rdfs:subClassOf obo:HP_0040006 . obo:HP_0011421 obo:IAO_0000115 "Death during adolescence, the period between childhood and adulthood (roughly between the ages of 10 and 19 years)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-16T06:38:44Z" ; oboInOwl:hasDbXref "UMLS:C4023368" ; oboInOwl:hasExactSynonym "Death in adolescence" ; oboInOwl:id "HP:0011421" ; a owl:Class ; rdfs:label "Death in adolescence" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0011422 obo:IAO_0000115 "An abnormality of chloride homeostasis or concentration in the body." ; dcterms:creator ; oboInOwl:creation_date "2012-03-16T06:09:15Z" ; oboInOwl:hasDbXref "UMLS:C4023367" ; oboInOwl:hasExactSynonym "Abnormal blood Cl concentration", "Abnormal blood Cl- concentration", "Abnormality of chloride homeostasis" ; oboInOwl:id "HP:0011422" ; a owl:Class ; rdfs:label "Abnormal blood chloride concentration" ; rdfs:subClassOf obo:HP_0003111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055064 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011423 obo:IAO_0000115 "An abnormally increased chloride concentration in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-03-16T06:09:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:74450001", "UMLS:C0085679" ; oboInOwl:id "HP:0011423" ; a owl:Class ; rdfs:label "Hyperchloremia" ; rdfs:subClassOf obo:HP_0011422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011424 obo:IAO_0000115 "An increased consentration of zinc in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T08:54:44Z" ; oboInOwl:hasDbXref "UMLS:C0854520", "UMLS:C0856208" ; oboInOwl:hasExactSynonym "Hyperzincemia" ; oboInOwl:id "HP:0011424" ; a owl:Class ; rdfs:label "Increased serum zinc" ; rdfs:subClassOf obo:HP_0008277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011425 obo:IAO_0000115 "An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T04:26:01Z" ; oboInOwl:hasDbXref "UMLS:C4023366" ; oboInOwl:hasExactSynonym "Foetal ultrasound soft marker" ; oboInOwl:id "HP:0011425" ; a owl:Class ; rdfs:comment "The screening ultrasound at 16 to 20 weeks should evaluate 8 markers, 5 of which (thickened nuchal fold, echogenic bowel, mild ventriculomegaly, echogenic focus in the heart, and choroid plexus cyst) are associated with an increased risk of fetal aneuploidy, and in some cases with nonchromosomal problems, while 3 (single umbilical artery, enlarged cisterna magna, and pyelectasis) are only associated with an increased risk of nonchromosomal abnormalities when seen in isolation (PMID:16100637)." ; rdfs:label "Fetal ultrasound soft marker" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0011426 obo:IAO_0000115 "Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T06:59:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:462165005", "UMLS:C3532166" ; oboInOwl:hasExactSynonym "Foetal choroid plexus cysts" ; oboInOwl:id "HP:0011426" ; a owl:Class ; rdfs:comment "There is agreement that ultrasound characteristics of CPC, such as bilaterality, size, number, complexity, and resolution, are not related to the risk of aneuploidy. However, cysts with diameters less than 5 mm may not be linked with trisomy and large cysts in excess of 10 mm may impart a higher risk." ; rdfs:label "Fetal choroid plexus cysts" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0034206 . obo:HP_0011427 obo:IAO_0000115 "The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vermis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:03:07Z" ; oboInOwl:hasDbXref "UMLS:C4023365" ; oboInOwl:hasExactSynonym "Enlarged foetal cisterna magna" ; oboInOwl:id "HP:0011427" ; a owl:Class ; rdfs:label "Enlarged fetal cisterna magna" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0034206 . obo:HP_0011428 obo:IAO_0000115 "A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:05:40Z" ; oboInOwl:hasDbXref "UMLS:C0743924" ; oboInOwl:hasExactSynonym "Short fetal thigh bone length", "Short foetal femur length", "Short foetal thigh bone length" ; oboInOwl:id "HP:0011428" ; a owl:Class ; rdfs:label "Short fetal femur length" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0025662 . obo:HP_0011429 obo:IAO_0000115 "A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:07:05Z" ; oboInOwl:hasDbXref "UMLS:C4023364" ; oboInOwl:hasExactSynonym "Short fetal long bone in upper arm length", "Short foetal humerus length", "Short foetal long bone in upper arm length" ; oboInOwl:id "HP:0011429" ; a owl:Class ; rdfs:label "Short fetal humerus length" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0025662 . obo:HP_0011430 obo:IAO_0000115 "On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:08:30Z" ; oboInOwl:hasDbXref "UMLS:C4023363" ; oboInOwl:hasExactSynonym "Hypoplasia of foetal nasal bone", "Underdeveloped fetal nose bone", "Underdeveloped foetal nose bone" ; oboInOwl:id "HP:0011430" ; a owl:Class ; rdfs:label "Hypoplasia of fetal nasal bone" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0025662 . obo:HP_0011431 obo:IAO_0000115 "Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (PMID:16100637)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:11:26Z" ; oboInOwl:hasBroadSynonym "Fetal little finger curvature", "Fetal pinkie finger curvature", "Fetal pinky finger curvature", "Foetal little finger curvature", "Foetal pinkie finger curvature", "Foetal pinky finger curvature" ; oboInOwl:hasDbXref "UMLS:C4023362", "UMLS:C4280326" ; oboInOwl:hasExactSynonym "Foetal fifth finger clinodactyly" ; oboInOwl:id "HP:0011431" ; a owl:Class ; rdfs:label "Fetal fifth finger clinodactyly" ; rdfs:subClassOf obo:HP_0011425, obo:HP_0025662 . obo:HP_0011432 obo:IAO_0000115 "Increase in the levels of maternal serum alpha-fetoprotein levels during pregnancy." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:45:07Z" ; oboInOwl:hasDbXref "UMLS:C4023361" ; oboInOwl:hasExactSynonym "High MSAFP MoM", "High maternal serum alpha-fetoprotein", "High maternal serum alpha-fetoprotein MoM", "Increased maternal serum alpha-fetoprotein level", "MSAFP MoM>2.5" ; oboInOwl:id "HP:0011432" ; a owl:Class ; rdfs:comment "Increased levels of maternal serum alpha-fetoprotein is often part of the triple (AFP, Estriol, and human chorionic gonadotropin) or quadruple screening tests (AFP, estriol, human chorionic gonadotropin and Inhibin A) for congenital birth defects. It can be seen in fetal neural tube defects (NTD), abdominal wall defects, congenital renal disease, esophageal atresia, other fetal distress situations (eg, threatened abortion and fetal demise), multiple pregnancy, placental chorioangioma and placental lakes and other fetal and maternal conditions. Association with various adverse pregnancy outcomes reported. Usually assessed in second trimester and values above 2.5 MoM considered as significantly increased. For NTD, a screen-negative result indicates that the calculated alpha-fetoprotein (AFP) multiple of the median (MoM) falls below the established cutoff of 2.50 MoM. A negative screen does not guarantee the absence of neural tube defects. A screen-positive result indicates that the calculated AFP MoM is 2.50 or greater and may indicate an increased risk for open NTD. The actual risk depends on the level of AFP and the individual's pretest risk of having a child with NTD based on family history, geographical location, maternal conditions such as diabetes and epilepsy, and use of folate prior to conception. A screen-positive result does not infer a definitive diagnosis of a NTD but indicates that further evaluation should be considered. Reduced levels of alpha-fetoprotein can be seen in some fetal disorders such as Down syndrome." ; rdfs:label "High maternal circulating alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0011433 obo:IAO_0000115 "An abnormally high concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:47:39Z" ; oboInOwl:hasDbXref "UMLS:C4021150" ; oboInOwl:hasExactSynonym "High maternal serum chorionic gonadotropin", "High maternal serum hCG" ; oboInOwl:id "HP:0011433" ; a owl:Class ; rdfs:comment "Reduced levels of alpha-fetoprotein can be seen in some fetal disorders such as Down syndrome." ; rdfs:label "High maternal circulating chorionic gonadotropin concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0011434 obo:IAO_0000115 "An abnormally low concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:48:26Z" ; oboInOwl:hasDbXref "UMLS:C4021149" ; oboInOwl:hasExactSynonym "Low maternal serum chorionic gonadotropin", "Low maternal serum hCG" ; oboInOwl:id "HP:0011434" ; a owl:Class ; rdfs:comment "Reduced levels of alpha-fetoprotein can be seen in some fetal disorders such as Down syndrome." ; rdfs:label "Low maternal circulating chorionic gonadotropin concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0011435 obo:IAO_0000115 "An abnormally low concentration of serum PAPP-A (pregnancy associated plasma protein A), as compared to normal values for gestational-age." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:51:25Z" ; oboInOwl:hasDbXref "UMLS:C4023360" ; oboInOwl:hasExactSynonym "Low maternal serum PAPP-A" ; oboInOwl:id "HP:0011435" ; a owl:Class ; rdfs:comment "Reduced levels of alpha-fetoprotein can be seen in some fetal disorders such as Down syndrome." ; rdfs:label "Low maternal circulating PAPP-A concentration" ; rdfs:subClassOf obo:HP_0011436 . obo:HP_0011436 obo:IAO_0000115 "An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:52:25Z" ; oboInOwl:hasDbXref "UMLS:C4023359" ; oboInOwl:id "HP:0011436" ; a owl:Class ; rdfs:label "Abnormal maternal serum screening" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0011437 obo:IAO_0000115 "A medical history of a fetus or child born to a mother with an autoimmune disease." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:54:31Z" ; oboInOwl:hasDbXref "UMLS:C4023358" ; oboInOwl:id "HP:0011437" ; a owl:Class ; rdfs:comment "Maternal autoimmune diseases with potential adverse effects for the fetus include autoimmune forms of hyperthyroidism and hypothyroidism, myasthenia gravis, systemic lupus erythematodes, and autoimmune forms of thrombocytopenia." ; rdfs:label "Maternal autoimmune disease" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0011438 obo:IAO_0000115 "A medical history of exposure of the mother of a child or fetus to a teratogenic substance during pregnancy." ; dcterms:creator ; oboInOwl:creation_date "2012-03-17T07:59:06Z" ; oboInOwl:hasDbXref "UMLS:C4023357" ; oboInOwl:id "HP:0011438" ; a owl:Class ; rdfs:comment "Commonly encountered maternal teratogens include alcohol, antiepileptic drugs, antihypertensive and antithyroid medications, aspirin, bisphosphonates, chemotherapy, monoclonal antibodies, ionizing radiation, recreational drugs, and serotonin-specific reuptake inhibitors (a class of antidepressants)." ; rdfs:label "Maternal teratogenic exposure" ; rdfs:subClassOf obo:HP_0031437 . obo:HP_0011439 obo:IAO_0000115 "Rhabdomyolysis induced by anesthesia." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T12:19:01Z" ; oboInOwl:hasDbXref "UMLS:C4023356" ; oboInOwl:id "HP:0011439" ; a owl:Class ; rdfs:label "Anesthetic-induced rhabdomylosis" ; rdfs:subClassOf obo:HP_0003201 . obo:HP_0011440 obo:IAO_0000115 "Rhabdomyolysis induced by intake of alcohol." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T12:21:35Z" ; oboInOwl:hasDbXref "UMLS:C4023355" ; oboInOwl:id "HP:0011440" ; a owl:Class ; rdfs:label "Alcohol-induced rhabdomyolysis" ; rdfs:subClassOf obo:HP_0003201 . obo:HP_0011441 obo:IAO_0000115 "An abnormality of the medulla oblongata, the lower half of the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T01:51:24Z" ; oboInOwl:hasDbXref "UMLS:C4021148" ; oboInOwl:hasExactSynonym "Abnormality of the medulla oblongata", "Abnormality of the myencephalon" ; oboInOwl:id "HP:0011441" ; a owl:Class ; rdfs:comment "The medulla oblongata, which is often referred to simply as the medulla, comprises the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures." ; rdfs:label "Abnormal medulla oblongata morphology" ; rdfs:subClassOf obo:HP_0002363, obo:HP_0011282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001896 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011442 obo:IAO_0000115 "An anomaly of the control or production of movement in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T02:29:04Z" ; oboInOwl:hasDbXref "UMLS:C4023354" ; oboInOwl:hasExactSynonym "Abnormality of central motor function" ; oboInOwl:id "HP:0011442" ; a owl:Class ; rdfs:label "Abnormal central motor function" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0011443 dcterms:creator ; oboInOwl:creation_date "2012-03-18T02:40:46Z" ; oboInOwl:hasDbXref "UMLS:C4023353" ; oboInOwl:hasExactSynonym "Abnormality of coordination", "Coordination issue" ; oboInOwl:id "HP:0011443" ; a owl:Class ; rdfs:label "Abnormality of coordination" ; rdfs:subClassOf obo:HP_0011442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000188 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011444 obo:IAO_0000115 "A type of rigidity in which the arms are in flexion and adduction and the legs are extended. This signifies a lesion in the cerebral white matter, internal capsules, or thalamus." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T03:30:10Z" ; oboInOwl:hasDbXref "MSH:D003655", "SNOMEDCT_US:36423000", "UMLS:C0231521" ; oboInOwl:id "HP:0011444" ; a owl:Class ; rdfs:comment "Decorticate posturing" ; rdfs:label "Decorticate rigidity" ; rdfs:subClassOf obo:HP_0002063 . obo:HP_0011445 obo:IAO_0000115 "A type of cerebral palsy characterized by slow, involuntary muscle movement and mixed muscle tone." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T03:53:04Z" ; oboInOwl:hasDbXref "MSH:D002547", "SNOMEDCT_US:230780007", "SNOMEDCT_US:75019001", "UMLS:C0270742" ; oboInOwl:hasRelatedSynonym "Dyskinetic cerebral palsy" ; oboInOwl:id "HP:0011445" ; a owl:Class ; rdfs:comment "Athetoid cerebral palsy is caused by damage to the basal ganglia." ; rdfs:label "Athetoid cerebral palsy" ; rdfs:subClassOf obo:HP_0002071, obo:HP_0100021 . obo:HP_0011446 obo:IAO_0000115 "Cognitive, psychiatric or memory anomaly." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T04:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4023352" ; oboInOwl:id "HP:0011446" ; a owl:Class ; rdfs:label "Abnormality of higher mental function" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0011447 obo:IAO_0000115 "Hyposegmented (hypolobulated) or bilobed neutrophil nuclei." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T04:44:22Z" ; oboInOwl:hasDbXref "MSH:D010381", "SNOMEDCT_US:85559002", "UMLS:C0030779", "UMLS:C4023351" ; oboInOwl:hasExactSynonym "Hyposegmentation of neutrophil nuclei in peripheral blood" ; oboInOwl:hasRelatedSynonym "Pelger-Huet anomaly" ; oboInOwl:id "HP:0011447" ; a owl:Class ; rdfs:comment "Hyposegmented cells are neutrophils with fewer than three nuclear lobes." ; rdfs:label "Hyposegmentation of neutrophil nuclei" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0011448 obo:IAO_0000115 "Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Ankle clonus is tested by rapidly flexing the foot upward." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T05:09:48Z" ; oboInOwl:hasAlternativeId "HP:0002541" ; oboInOwl:hasDbXref "SNOMEDCT_US:39055007", "UMLS:C0238651" ; oboInOwl:hasExactSynonym "Abnormal rhythmic movements of ankle" ; oboInOwl:id "HP:0011448" ; a owl:Class ; rdfs:comment "Ankle clonus is generally caused by corticospinal disease." ; rdfs:label "Ankle clonus" ; rdfs:subClassOf obo:HP_0002169, obo:HP_0034674 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002169 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011449 obo:IAO_0000115 "Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Knee clonus can be tested by rapidly pushing the patella towards the toes." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T05:11:32Z" ; oboInOwl:hasAlternativeId "HP:0002325" ; oboInOwl:hasDbXref "SNOMEDCT_US:54360005", "UMLS:C0520823" ; oboInOwl:hasExactSynonym "Patellar clonus" ; oboInOwl:id "HP:0011449" ; a owl:Class ; rdfs:label "Knee clonus" ; rdfs:subClassOf obo:HP_0002169 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002169 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001485 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011450 obo:IAO_0000115 "A type of infection of the central nervous system that can be regarded as a sign of a pathological susceptibility to infection." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T05:57:29Z" ; oboInOwl:hasDbXref "MSH:D002494", "SNOMEDCT_US:128117002", "UMLS:C0007684" ; oboInOwl:hasExactSynonym "Central nervous system infection" ; oboInOwl:id "HP:0011450" ; a owl:Class ; rdfs:label "Unusual CNS infection" ; rdfs:subClassOf obo:HP_0002011, obo:HP_0032158 . obo:HP_0011451 obo:IAO_0000115 "Head circumference below 2 standard deviations below the mean for age and gender at birth." ; dcterms:creator ; oboInOwl:creation_date "2012-03-18T06:50:36Z" ; oboInOwl:hasBroadSynonym "Congenital small head", "Congenital small head circumference", "Small head circumference present at birth", "Small head present at birth", "Small skull present at birth" ; oboInOwl:hasDbXref "UMLS:C2677180", "UMLS:C4020749" ; oboInOwl:hasExactSynonym "Congenital decreased head circumference", "Congenital microcephaly", "Congenital small skull", "Decreased head circumference present at birth", "Microcephaly present at birth", "Small cranium present at birth" ; oboInOwl:hasRelatedSynonym "Head circumference small for gestational age" ; oboInOwl:id "HP:0011451" ; a owl:Class ; rdfs:label "Primary microcephaly" ; rdfs:subClassOf obo:HP_0000252 . obo:HP_0011452 obo:IAO_0000115 "An abnormality of the function of the middle ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-19T09:33:03Z" ; oboInOwl:hasDbXref "UMLS:C4021846" ; oboInOwl:hasExactSynonym "Functional abnormality of the middle ear" ; oboInOwl:id "HP:0011452" ; a owl:Class ; rdfs:comment "The middle ear comprises the tympanic cavity in the temporal bone of the skull behind the eardrum, and is separated from the outer ear by the ear drum. The tympanic cavity contains the auditory ossicles (malleus, incus, stapes) that vibrate when exposed to sound, forming a chain that extends to the oval window of the inner ear and whose main function is to amplify sound. Additionally, the middle ear connects to the back of the throat and nose through the Eustachian tube." ; rdfs:label "Functional abnormality of the middle ear" ; rdfs:subClassOf obo:HP_0000370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011453 obo:IAO_0000115 "An abnormality of the incus, an ossicle in the middle ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-19T09:38:20Z" ; oboInOwl:hasDbXref "UMLS:C4023350" ; oboInOwl:id "HP:0011453" ; a owl:Class ; rdfs:label "Abnormality of the incus" ; rdfs:subClassOf obo:HP_0004452 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001688 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011454 obo:IAO_0000115 "An abnormality of the malleus, an ossicle in the middle ear." ; dcterms:creator ; oboInOwl:creation_date "2012-03-19T09:40:02Z" ; oboInOwl:hasDbXref "UMLS:C4023349" ; oboInOwl:id "HP:0011454" ; a owl:Class ; rdfs:label "Abnormality of the malleus" ; rdfs:subClassOf obo:HP_0004452 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011455 obo:IAO_0000115 "Aplasia of the malleus." ; dcterms:creator ; oboInOwl:creation_date "2012-03-19T09:40:08Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:300169003", "UMLS:C0576900" ; oboInOwl:id "HP:0011455" ; a owl:Class ; rdfs:label "Absent malleus" ; rdfs:subClassOf obo:HP_0011454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011456 obo:IAO_0000115 "Aplasia of the stapes." ; dcterms:creator ; oboInOwl:creation_date "2012-03-19T09:42:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:300178009", "UMLS:C0576909" ; oboInOwl:id "HP:0011456" ; a owl:Class ; rdfs:label "Absent stapes" ; rdfs:subClassOf obo:HP_0008628 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001687 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011457 obo:IAO_0000115 "This term refers to the loss of eyelashes that were previously present." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T09:15:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:34887006", "UMLS:C0271321" ; oboInOwl:hasExactSynonym "Ciliary Madarosis", "Eyelashes fell out", "Loss of eyelashes", "Milphosis", "Missing eyelashes" ; oboInOwl:id "HP:0011457" ; a owl:Class ; rdfs:comment "Common causes of loss of eyelashes include inflammation, autoimmunity, tumors,endocrine disorders, drugs and medications, and a number of congenital conditions." ; rdfs:label "Loss of eyelashes" ; rdfs:subClassOf obo:HP_0000499 . obo:HP_0011458 obo:IAO_0000115 "A subjective manifestation of disease localized to the abdomen." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T05:35:45Z" ; oboInOwl:hasDbXref "UMLS:C0740651" ; oboInOwl:id "HP:0011458" ; a owl:Class ; rdfs:label "Abdominal symptom" ; rdfs:subClassOf obo:HP_0025032 . obo:HP_0011459 obo:IAO_0000115 "The presence of a carcinoma of the esophagus." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T06:55:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:372138000", "UMLS:C0152018" ; oboInOwl:id "HP:0011459" ; a owl:Class ; rdfs:label "Esophageal carcinoma" ; rdfs:subClassOf obo:HP_0100751 . obo:HP_0011460 obo:IAO_0000115 "Onset of disease at up to 8 weeks following fertilization (corresponding to 10 weeks of gestation)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T06:57:48Z" ; oboInOwl:hasDbXref "UMLS:C4023348" ; oboInOwl:id "HP:0011460" ; a owl:Class ; rdfs:comment "The time interval of a gestation is called the gestation period. In human obstetrics, gestational age refers to the fertilization age plus two weeks. This is approximately the duration since the woman's last menstrual period began." ; rdfs:label "Embryonal onset" ; rdfs:subClassOf obo:HP_0030674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000002 ] ) ] . obo:HP_0011461 obo:IAO_0000115 "Onset prior to birth but after 8 weeks of embryonic development (corresponding to a gestational age of 10 weeks)." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T06:58:21Z" ; oboInOwl:hasDbXref "UMLS:C4023347" ; oboInOwl:hasExactSynonym "Foetal onset" ; oboInOwl:id "HP:0011461" ; a owl:Class ; rdfs:comment "The time interval of a gestation is called the gestation period. In human obstetrics, gestational age refers to the fertilization age plus two weeks. This is approximately the duration since the woman's last menstrual period began." ; rdfs:label "Fetal onset" ; rdfs:subClassOf obo:HP_0030674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000037 ] ) ] . obo:HP_0011462 obo:IAO_0000115 "Onset of disease at the age of between 16 and 40 years." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:01:15Z" ; oboInOwl:hasDbXref "UMLS:C3554568" ; oboInOwl:id "HP:0011462" ; a owl:Class ; rdfs:label "Young adult onset" ; rdfs:subClassOf obo:HP_0003581 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000089 ] ) ] . obo:HP_0011463 obo:IAO_0000115 "Onset of disease at the age of between 1 and 5 years." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:16:20Z" ; oboInOwl:hasAlternativeId "HP:0003586", "HP:0003617" ; oboInOwl:hasDbXref "UMLS:C1837352" ; oboInOwl:hasExactSynonym "Symptoms begin in childhood" ; oboInOwl:id "HP:0011463" ; a owl:Class ; rdfs:comment "This term refers to ages up to but not including the fifth birthday (see Juvenile onset)." ; rdfs:label "Childhood onset" ; rdfs:subClassOf obo:HP_0410280 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000081 ] ) ] . obo:HP_0011464 obo:IAO_0000115 "A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:36:49Z" ; oboInOwl:hasDbXref "UMLS:C4023346" ; oboInOwl:id "HP:0011464" ; a owl:Class ; rdfs:label "Aganglionosis of the small intestine" ; rdfs:subClassOf obo:HP_0004362 . obo:HP_0011465 obo:IAO_0000115 "A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the duodenum." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:38:12Z" ; oboInOwl:hasDbXref "UMLS:C4023345" ; oboInOwl:id "HP:0011465" ; a owl:Class ; rdfs:label "Duodenal aganglionosis" ; rdfs:subClassOf obo:HP_0011464 . obo:HP_0011466 obo:IAO_0000115 "Absence or underdevelopment of the gallbladder." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:40:20Z" ; oboInOwl:hasDbXref "UMLS:C4023344" ; oboInOwl:hasExactSynonym "Absent/small gallbladder", "Absent/underdeveloped gallbladder" ; oboInOwl:id "HP:0011466" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the gallbladder" ; rdfs:subClassOf obo:HP_0012437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011467 obo:IAO_0000115 "A developmental defect in which the gallbladder fails to form." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:41:14Z" ; oboInOwl:hasDbXref "MSH:C562564", "SNOMEDCT_US:86507001", "UMLS:C0266251" ; oboInOwl:hasExactSynonym "Absent gallbladder", "Agenesis of the gallbladder", "Aplasia of the gallbladder" ; oboInOwl:id "HP:0011467" ; a owl:Class ; rdfs:label "Absent gallbladder" ; rdfs:subClassOf obo:HP_0011466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011468 obo:IAO_0000115 "Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:45:47Z" ; oboInOwl:hasBroadSynonym "Myoclonus of facial muscles" ; oboInOwl:hasDbXref "SNOMEDCT_US:230335009", "SNOMEDCT_US:32402008", "UMLS:C0278151", "UMLS:C0338467", "UMLS:C0858722", "UMLS:C4280324", "UMLS:C4280325" ; oboInOwl:hasExactSynonym "Cramping of facial muscles", "Facial spasms", "Facial tics", "Jerking of facial muscles", "Mimic spasms", "Spasms of facial muscles", "Twitching of facial muscles" ; oboInOwl:hasRelatedSynonym "Involuntary facial muscle spasms", "Muscle spasm of face" ; oboInOwl:id "HP:0011468" ; a owl:Class ; rdfs:label "Facial tics" ; rdfs:subClassOf obo:HP_0005324 . obo:HP_0011469 obo:IAO_0000115 "Regurgitation of milk through the nose." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:52:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:85023004", "UMLS:C0232608" ; oboInOwl:id "HP:0011469" ; a owl:Class ; rdfs:label "Nasal regurgitation" ; rdfs:subClassOf obo:HP_0008872 . obo:HP_0011470 obo:IAO_0000115 "Feeding problem necessitating nasogastric tube feeding." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T07:53:46Z" ; oboInOwl:hasDbXref "UMLS:C4023343" ; oboInOwl:id "HP:0011470" ; a owl:Class ; rdfs:comment "This is a severe form of feeding problems in infancy." ; rdfs:label "Nasogastric tube feeding in infancy" ; rdfs:subClassOf obo:HP_0008872, obo:HP_0033454 . obo:HP_0011471 obo:IAO_0000115 "Feeding problem necessitating gastrostomy tube feeding." ; dcterms:creator ; oboInOwl:creation_date "2012-03-25T10:00:00Z" ; oboInOwl:hasDbXref "UMLS:C4020748", "UMLS:C4023342" ; oboInOwl:hasRelatedSynonym "PEG-fed in infancy" ; oboInOwl:id "HP:0011471" ; a owl:Class ; rdfs:comment "This is an extremely severe form of feeding problems in infancy." ; rdfs:label "Gastrostomy tube feeding in infancy" ; rdfs:subClassOf obo:HP_0008872, obo:HP_0033454 . obo:HP_0011472 dcterms:creator ; oboInOwl:creation_date "2012-03-26T08:16:03Z" ; oboInOwl:hasDbXref "UMLS:C4023341" ; oboInOwl:hasExactSynonym "Abnormal shape of small intestinal villus" ; oboInOwl:id "HP:0011472" ; a owl:Class ; rdfs:label "Abnormality of small intestinal villus morphology" ; rdfs:subClassOf obo:HP_0025129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001213 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011473 obo:IAO_0000115 "The enteric villi are atrophic or absent." ; dcterms:creator ; oboInOwl:creation_date "2012-03-26T08:18:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:275403002", "SNOMEDCT_US:75581001", "UMLS:C0267456", "UMLS:C0554101", "UMLS:C1833058", "UMLS:C1859541", "UMLS:C2677378", "UMLS:C4020747" ; oboInOwl:hasExactSynonym "Atrophy of small intestinal villi", "Villous degeneration" ; oboInOwl:hasRelatedSynonym "Biopsy shows villous atrophy", "Duodenal villous atrophy", "Small intestine biopsy shows villous atrophy", "Variable degree of villous atrophy" ; oboInOwl:id "HP:0011473" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Villous atrophy" ; rdfs:subClassOf obo:HP_0011472 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001213 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011474 obo:IAO_0000115 "Sensorineural hearing impairment with childhood onset." ; dcterms:creator ; oboInOwl:creation_date "2012-03-30T07:18:09Z" ; oboInOwl:hasDbXref "UMLS:C4023340" ; oboInOwl:id "HP:0011474" ; a owl:Class ; rdfs:label "Childhood onset sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0011475 obo:IAO_0000115 "Persistence of the stapedial artery, which normally regresses during embryonic life." ; dcterms:creator ; oboInOwl:creation_date "2012-03-31T08:38:23Z" ; oboInOwl:hasDbXref "UMLS:C4023339" ; oboInOwl:id "HP:0011475" ; a owl:Class ; rdfs:label "Persistent stapedial artery" ; rdfs:subClassOf obo:HP_0008609 . obo:HP_0011476 obo:IAO_0000115 "Complete loss of hearing related to a sensorineural defect." ; dcterms:creator ; oboInOwl:creation_date "2012-03-31T10:21:17Z" ; oboInOwl:hasDbXref "UMLS:C4023338" ; oboInOwl:id "HP:0011476" ; a owl:Class ; rdfs:label "Profound sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407, obo:HP_0012715 . obo:HP_0011477 obo:IAO_0000115 "In primary position, the eyes drift slowly downward and then spontaneously beat upward. Upward gaze accentuates the nystagmus. The associated oscillopsias are often very irritating, but the symptoms are usually transient." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T10:54:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:307677002", "UMLS:C0585545" ; oboInOwl:id "HP:0011477" ; a owl:Class ; rdfs:comment "In most cases, paramedian lesions in the medulla oblongata or the midbrain are found, for example, in patients with multiple sclerosis, brainstem ischemia or tumors, or Wernicke's encephalopathy." ; rdfs:label "Upbeat nystagmus" ; rdfs:subClassOf obo:HP_0010544 . obo:HP_0011478 obo:IAO_0000115 "Absence of globe, optic nerve, chiasm and optic tracts. No evidence of ocular tissue on MRI scan or examination." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T12:19:11Z" ; oboInOwl:hasDbXref "UMLS:C2675590" ; oboInOwl:hasExactSynonym "Complete anophthalmia", "Completely missing eyeball", "Total anophthalmia" ; oboInOwl:id "HP:0011478" ; a owl:Class ; rdfs:comment "True anophthalmia implies an early failure of eye development." ; rdfs:label "True anophthalmia" ; rdfs:subClassOf obo:HP_0000528 . obo:HP_0011479 obo:IAO_0000115 "An abnormality of the lacrimal punctum, an opening on the eyelid close to the medial canthus that drains tears from the conjunctival sac into the lacrimal duct in the same eyelid." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T09:08:05Z" ; oboInOwl:hasDbXref "UMLS:C4023337" ; oboInOwl:hasExactSynonym "Abnormality of the lacrimal punctum" ; oboInOwl:id "HP:0011479" ; a owl:Class ; rdfs:label "Abnormal lacrimal punctum morphology" ; rdfs:subClassOf obo:HP_0000614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010284 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011480 obo:IAO_0000115 "A developmental anomaly characterized by abnormal smallness of one eye." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T12:35:57Z" ; oboInOwl:hasDbXref "UMLS:C3640024", "UMLS:C4280323" ; oboInOwl:hasExactSynonym "Abnormally small eyeball on one side" ; oboInOwl:hasNarrowSynonym "Unilateral nanophthalmos" ; oboInOwl:id "HP:0011480" ; a owl:Class ; rdfs:label "Unilateral microphthalmos" ; rdfs:subClassOf obo:HP_0000568 . obo:HP_0011481 obo:IAO_0000115 "An abnormality of the lacrimal duct, a duct that drain tears from the conjunctiva, via the lacrimal puncta, into the lacrimal sac." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T09:11:55Z" ; oboInOwl:hasDbXref "UMLS:C1858567" ; oboInOwl:hasExactSynonym "Abnormality of the lacrimal canaliculus", "Abnormality of the lacrimal duct" ; oboInOwl:id "HP:0011481" ; a owl:Class ; rdfs:label "Abnormal lacrimal duct morphology" ; rdfs:subClassOf obo:HP_0000614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001850 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011482 obo:IAO_0000115 "Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye." ; dcterms:creator ; oboInOwl:creation_date "2012-04-01T09:35:54Z" ; oboInOwl:hasDbXref "UMLS:C4023336" ; oboInOwl:hasExactSynonym "Abnormality of the lacrimal gland" ; oboInOwl:id "HP:0011482" ; a owl:Class ; rdfs:label "Abnormal lacrimal gland morphology" ; rdfs:subClassOf obo:HP_0000614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001817 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011483 obo:IAO_0000115 "Adhesions between the iris and the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T08:50:23Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:70992005", "UMLS:C0152252" ; oboInOwl:hasExactSynonym "Anterior synechiae", "Cornea-iris adhesion", "Iridocorneal adhesions", "Iridocorneal synechia" ; oboInOwl:id "HP:0011483" ; a owl:Class ; rdfs:label "Anterior synechiae of the anterior chamber" ; rdfs:subClassOf obo:HP_0007833 . obo:HP_0011484 obo:IAO_0000115 "Adhesions between the iris and the lens." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T08:50:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:111512005", "UMLS:C0152253" ; oboInOwl:hasExactSynonym "Iridolenticular adhesions", "Posterior synechiae" ; oboInOwl:id "HP:0011484" ; a owl:Class ; rdfs:label "Posterior synechiae of the anterior chamber" ; rdfs:subClassOf obo:HP_0007833 . obo:HP_0011485 obo:IAO_0000115 "Developmental abnormality in which the lens and cornea are not separated." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T08:52:43Z" ; oboInOwl:hasDbXref "UMLS:C4023334" ; oboInOwl:id "HP:0011485" ; a owl:Class ; rdfs:label "Corneolenticular adhesion" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0011486 obo:IAO_0000115 "An abnormal anteroposterior thickness of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:15:01Z" ; oboInOwl:hasDbXref "UMLS:C4023333" ; oboInOwl:id "HP:0011486" ; a owl:Class ; rdfs:label "Abnormality of corneal thickness" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000915 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011487 obo:IAO_0000115 "A increased anteroposterior thickness of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:17:35Z" ; oboInOwl:hasDbXref "UMLS:C3810451" ; oboInOwl:id "HP:0011487" ; a owl:Class ; rdfs:label "Increased corneal thickness" ; rdfs:subClassOf obo:HP_0011486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011488 obo:IAO_0000115 "Abnormality of the corneal endothelium, that is, the single layer of cells on the inner surface of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:18:50Z" ; oboInOwl:hasDbXref "UMLS:C4023332" ; oboInOwl:hasExactSynonym "Abnormality of corneal endothelium" ; oboInOwl:id "HP:0011488" ; a owl:Class ; rdfs:label "Abnormal corneal endothelium morphology" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001985 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011489 obo:IAO_0000115 "Abnormal migration of corneal endothelium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:20:17Z" ; oboInOwl:hasDbXref "UMLS:C4023331" ; oboInOwl:id "HP:0011489" ; a owl:Class ; rdfs:comment "Can be seen in posterior polymorphous corneal dystrophy." ; rdfs:label "Abnormal migration of corneal endothelium" ; rdfs:subClassOf obo:HP_0011488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0016477 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001985 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011490 obo:IAO_0000115 "Abnormality of Descemet's membrane, which is the basement membrane of the corneal endothelium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:23:11Z" ; oboInOwl:hasDbXref "UMLS:C4023330" ; oboInOwl:hasExactSynonym "Abnormality of Descemet's membrane" ; oboInOwl:id "HP:0011490" ; a owl:Class ; rdfs:label "Abnormal Descemet membrane morphology" ; rdfs:subClassOf obo:HP_0011488 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011491 obo:IAO_0000115 "A reduction in the number of corneal endothelial cells." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:24:23Z" ; oboInOwl:hasDbXref "UMLS:C4023329" ; oboInOwl:id "HP:0011491" ; a owl:Class ; rdfs:label "Reduced number of corneal endothelial cells" ; rdfs:subClassOf obo:HP_0011488 . obo:HP_0011492 obo:IAO_0000115 "An abnormality of the stroma of cornea, also known as the substantia propria of cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:28:49Z" ; oboInOwl:hasDbXref "UMLS:C4023328" ; oboInOwl:hasExactSynonym "Abnormality of corneal stroma" ; oboInOwl:id "HP:0011492" ; a owl:Class ; rdfs:label "Abnormal corneal stroma morphology" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011493 obo:IAO_0000115 "Reduced transparency of the central portion of the corneal stroma." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:36:22Z" ; oboInOwl:hasDbXref "UMLS:C4023327" ; oboInOwl:id "HP:0011493" ; a owl:Class ; rdfs:label "Central opacification of the cornea" ; rdfs:subClassOf obo:HP_0007759 . obo:HP_0011494 obo:IAO_0000115 "Generalized reduced transparency of the stroma of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-02T10:39:50Z" ; oboInOwl:hasDbXref "UMLS:C4021147" ; oboInOwl:hasExactSynonym "Generalised opacification of the cornea" ; oboInOwl:id "HP:0011494" ; a owl:Class ; rdfs:label "Generalized opacification of the cornea" ; rdfs:subClassOf obo:HP_0007759 . obo:HP_0011495 obo:IAO_0000115 "Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-03T07:10:49Z" ; oboInOwl:hasDbXref "UMLS:C4023326" ; oboInOwl:hasExactSynonym "Abnormality of corneal epithelium" ; oboInOwl:id "HP:0011495" ; a owl:Class ; rdfs:label "Abnormal corneal epithelium morphology" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001772 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011496 obo:IAO_0000115 "Ingrowth of new blood vessels into the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-03T07:15:37Z" ; oboInOwl:hasDbXref "MSH:D016510", "SNOMEDCT_US:19161004", "UMLS:C0085109" ; oboInOwl:hasExactSynonym "Corneal neovascularisation", "Corneal vascularization", "Limbal neovascularization", "New blood vessel formation in cornea" ; oboInOwl:hasNarrowSynonym "Corneal pannus" ; oboInOwl:id "HP:0011496" ; a owl:Class ; rdfs:comment "New blood vessels, which sprout from the capillaries and venules of the pericorneal plexus, may block light, compromise visual acuity, and lead to inflammation, corneal scarring, and edema. Corneal neovascularization may be a consequence of corneal hypoxia. Neovascular patterns can be separated into three clinical groups: deep neovascularization overlying Descemet's membrane (seen in herpetic and luetic interstitial keratitis), stromal neovascularization (as a result of stromal keratitis), and vascular pannus (from ocular surface disorders). Corneal pannus is subepithelial fibrovascular tissue ingrowth from the limbus onto the cornea that can be observed with corneal neovascularization." ; rdfs:label "Corneal neovascularization" ; rdfs:subClassOf obo:HP_0000481 . obo:HP_0011497 obo:IAO_0000115 "New growth of vessels on the surface of the iris." ; dcterms:creator ; oboInOwl:creation_date "2012-04-03T07:32:43Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:51995000", "UMLS:C0154916" ; oboInOwl:hasExactSynonym "Neovascularization of the iris", "New blood vessel formation in iris" ; oboInOwl:id "HP:0011497" ; a owl:Class ; rdfs:label "Iris neovascularization" ; rdfs:subClassOf obo:HP_0007905 . obo:HP_0011498 obo:IAO_0100001 "HP:0000526" ; oboInOwl:creation_date "2012-04-03T07:38:24Z" ; oboInOwl:id "HP:0011498" ; a owl:Class ; rdfs:label "obsolete Partial aniridia" ; owl:deprecated true . obo:HP_0011499 obo:IAO_0000115 "Abnormal dilatation of the iris." ; dcterms:creator ; oboInOwl:creation_date "2012-04-03T07:49:21Z" ; oboInOwl:hasDbXref "MSH:D015878", "SNOMEDCT_US:37125009", "UMLS:C0026961" ; oboInOwl:hasExactSynonym "Dilated pupil" ; oboInOwl:id "HP:0011499" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Mydriasis" ; rdfs:subClassOf obo:HP_0007686 . obo:HP_0011500 obo:IAO_0000115 "Multiple pupils." ; dcterms:creator ; oboInOwl:creation_date "2012-04-04T07:19:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204159004", "UMLS:C0344544" ; oboInOwl:hasExactSynonym "Multiple pupils" ; oboInOwl:id "HP:0011500" ; a owl:Class ; rdfs:label "Polycoria" ; rdfs:subClassOf obo:HP_0000615 . obo:HP_0011501 obo:IAO_0000115 "A conical projection of the anterior surface of the lens, occurring as a developmental anomaly." ; dcterms:creator ; oboInOwl:creation_date "2012-04-04T07:54:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95480008", "UMLS:C0344262" ; oboInOwl:id "HP:0011501" ; a owl:Class ; rdfs:label "Anterior lenticonus" ; rdfs:subClassOf obo:HP_0001142 . obo:HP_0011502 obo:IAO_0000115 "A conical projection of the posterior surface of the lens, occurring as a developmental anomaly." ; dcterms:creator ; oboInOwl:creation_date "2012-04-04T07:55:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95482000", "UMLS:C0344263" ; oboInOwl:id "HP:0011502" ; a owl:Class ; rdfs:label "Posterior lenticonus" ; rdfs:subClassOf obo:HP_0001142 . obo:HP_0011503 obo:IAO_0000115 "Congenital absence of the fovea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T08:40:21Z" ; oboInOwl:hasDbXref "UMLS:C4023324" ; oboInOwl:hasExactSynonym "Absent fovea" ; oboInOwl:id "HP:0011503" ; a owl:Class ; rdfs:comment "Aplasia of the fovea can occur in aniridia and albinism." ; rdfs:label "Aplasia of the fovea" ; rdfs:subClassOf obo:HP_0008060 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011504 obo:IAO_0000115 "Progressive maculopathy characterized by concentric regions of hyper- and hypo-pigmentation." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T08:57:53Z" ; oboInOwl:hasDbXref "MSH:C537833", "SNOMEDCT_US:312958000", "SNOMEDCT_US:424169002", "UMLS:C0730330", "UMLS:C1828210" ; oboInOwl:hasExactSynonym "Chloroquine retinopathy" ; oboInOwl:id "HP:0011504" ; a owl:Class ; rdfs:label "Bull's eye maculopathy" ; rdfs:subClassOf obo:HP_0008002 . obo:HP_0011505 obo:IAO_0000115 "Cystoid macular edema (CME) is any type of macular edema that involves cyst formation." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:12:59Z" ; oboInOwl:hasDbXref "MSH:D008269", "SNOMEDCT_US:193387007", "UMLS:C0024440" ; oboInOwl:hasExactSynonym "Cystoid macular oedema" ; oboInOwl:id "HP:0011505" ; a owl:Class ; rdfs:comment "CME can occur with Irvine-Gass syndrome and other disorders." ; rdfs:label "Cystoid macular edema" ; rdfs:subClassOf obo:HP_0040049 . obo:HP_0011506 obo:IAO_0000115 "Choroidal neovascularization (CNV) is the creation of new blood vessels in the choroid layer of the eye." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:28:46Z" ; oboInOwl:hasDbXref "UMLS:C4023323" ; oboInOwl:hasExactSynonym "Choroidal neovascular membrane" ; oboInOwl:id "HP:0011506" ; a owl:Class ; rdfs:comment "This is a common symptom of the degenerative maculopathy wet age-related macular degeneration." ; rdfs:label "Choroidal neovascularization" ; rdfs:subClassOf obo:HP_0001103, obo:HP_0025568 . obo:HP_0011507 obo:IAO_0000115 "Pale often indistinct lesions of the macula." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:38:42Z" ; oboInOwl:hasDbXref "UMLS:C4023322" ; oboInOwl:id "HP:0011507" ; a owl:Class ; rdfs:label "Macular flecks" ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0011508 obo:IAO_0000115 "A macular hole is a small break in the macula, located in the center of the retina." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:39:58Z" ; oboInOwl:hasDbXref "MSH:D012167", "SNOMEDCT_US:232006002", "UMLS:C0024441" ; oboInOwl:id "HP:0011508" ; a owl:Class ; rdfs:label "Macular hole" ; rdfs:subClassOf obo:HP_0001103, obo:HP_0011958 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011509 obo:IAO_0000115 "Increased amount of pigmentation in the macula lutea." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:52:11Z" ; oboInOwl:hasDbXref "UMLS:C0745109" ; oboInOwl:id "HP:0011509" ; a owl:Class ; rdfs:label "Macular hyperpigmentation" ; rdfs:subClassOf obo:HP_0008002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000053 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011510 obo:IAO_0000115 "Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:54:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:18695008", "UMLS:C1260959" ; oboInOwl:id "HP:0011510" ; a owl:Class ; rdfs:label "Drusen" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0011511 obo:IAO_0000115 "Splitting of the retina in the macular region." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:55:43Z" ; oboInOwl:hasDbXref "UMLS:C4023321" ; oboInOwl:id "HP:0011511" ; a owl:Class ; rdfs:comment "This abnormality can be seen in X-linked retinoschisis." ; rdfs:label "Macular schisis" ; rdfs:subClassOf obo:HP_0030498 . obo:HP_0011512 obo:IAO_0000115 "Increased pigmentation of the fundus" ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T10:34:11Z" ; oboInOwl:hasDbXref "UMLS:C4021146" ; oboInOwl:hasExactSynonym "Hyperpigmented fundi", "Hyperpigmented fundus" ; oboInOwl:id "HP:0011512" ; a owl:Class ; rdfs:label "Hyperpigmentation of the fundus" ; rdfs:subClassOf obo:HP_0031605 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003951 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011513 obo:IAO_0000115 "A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous angioma are described as having a 'cluster of grapes' appearance." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T04:12:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:312937006", "UMLS:C0730304" ; oboInOwl:id "HP:0011513" ; a owl:Class ; rdfs:comment "The lesions are variable in size and location, and frequently follow the course of a major retinal vein. Epiretinal membranes are a common feature. In contrast to retinal capillary hemangiomas, cavernous hemangiomas lack prominent feeder vessels, intraretinal exudate, and surrounding subretinal fluid. Because the fundoscopic features are characteristic, diagnosis can generally be made based upon clinical appearance." ; rdfs:label "Retinal cavernous angioma" ; rdfs:subClassOf obo:HP_0007797 . obo:HP_0011514 obo:IAO_0000115 "An abnormality of binocular vision, that is of the ability to synthesize the visual inputs from both eyes to a single image with perception of depth." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:00:34Z" ; oboInOwl:hasDbXref "UMLS:C4023320" ; oboInOwl:id "HP:0011514" ; a owl:Class ; rdfs:label "Abnormality of binocular vision" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0011515 obo:IAO_0000115 "Inability to make fine depth discriminations from parallax provided by the two eyes' different positions on the head." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:03:49Z" ; oboInOwl:hasDbXref "UMLS:C4023319" ; oboInOwl:id "HP:0011515" ; a owl:Class ; rdfs:label "Abnormal stereopsis" ; rdfs:subClassOf obo:HP_0011514 . obo:HP_0011516 obo:IAO_0000115 "A condition where the retina contains no functional cone cells, so that in addition to the absence of color discrimination, vision in lights of normal intensity is difficult." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:40:03Z" ; oboInOwl:hasDbXref "MSH:C536021", "SNOMEDCT_US:102450007", "UMLS:C0302129" ; oboInOwl:hasExactSynonym "Rod monochromacy", "Rod monochromatism" ; oboInOwl:id "HP:0011516" ; a owl:Class ; rdfs:comment "The end stage of cone degeneration is rod monochromacy, also called achromatopsia, in which vision is mediated exclusively by rod photoreceptors. Rod monochromacy can also be manifest from birth and can be due to congenitally absent or dysfunctional cone photoreceptors. There is no rod counterpart to cone degeneration; all rod photoreceptor degenerations have a secondary loss of cones and are categorized as retinitis pigmentosa." ; rdfs:label "Achromatopsia" ; rdfs:subClassOf obo:HP_0007803 . obo:HP_0011517 obo:IAO_0000115 "The condition of having both rods and cones, but only a single kind of cone. Affected individuals have good pattern vision in daylight, but cannot distinguish between colors." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:40:33Z" ; oboInOwl:hasDbXref "UMLS:C4023318" ; oboInOwl:id "HP:0011517" ; a owl:Class ; rdfs:comment "There are three differing forms of cone monochromacy, named according to the residual functioning cone class, (1) blue cone (S-cone) monochromacy, green cone (M-cone) monochromacy, and red cone (L-cone) monochromacy." ; rdfs:label "Cone monochromacy" ; rdfs:subClassOf obo:HP_0007803 . obo:HP_0011518 obo:IAO_0000115 "Individuals affected by dichromacy possess only two types of cones, instead of three." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:46:27Z" ; oboInOwl:hasDbXref "UMLS:C4023317" ; oboInOwl:id "HP:0011518" ; a owl:Class ; rdfs:comment "The three types of dichromacy (protanopia, deuteranopia, and tritanopia) are named according the cone photopigment that is missing." ; rdfs:label "Dichromacy" ; rdfs:subClassOf obo:HP_0007641 . obo:HP_0011519 obo:IAO_0000115 "Individuals with anomalous trichromacy possess three types of cones, but one of the three types of cones has an abnormal spectral sensitivity compared to normal cones." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T06:57:10Z" ; oboInOwl:hasDbXref "UMLS:C4023316" ; oboInOwl:id "HP:0011519" ; a owl:Class ; rdfs:comment "Because the spectral sensitivities of individuals with anomalous trichromacy are shifted compared to normal, they mix the primary colors in different proportions." ; rdfs:label "Anomalous trichromacy" ; rdfs:subClassOf obo:HP_0007641 . obo:HP_0011520 obo:IAO_0000115 "A type of anomalous trichromacy associated with abnormal M photopigment, such that the absorption spectrum is shifted toward L wavelengths. Affected individuals have difficulties distinguishing between red and green." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T07:14:19Z" ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:246674000", "SNOMEDCT_US:77479002", "UMLS:C0155016" ; oboInOwl:hasExactSynonym "Deuteranomoly", "Green-weak" ; oboInOwl:id "HP:0011520" ; a owl:Class ; rdfs:comment "Note that protanomaly and deuteranomaly are both associated with difficulties distinguishing red and green." ; rdfs:label "Deuteranomaly" ; rdfs:subClassOf obo:HP_0000642, obo:HP_0011519 . obo:HP_0011521 obo:IAO_0000115 "Complete lack of the M photopigment, which is replaced with the L photopigment. Affected individuals tend to confuse red and green." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T07:34:40Z" ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:246674000", "SNOMEDCT_US:77479002", "UMLS:C0155016" ; oboInOwl:hasExactSynonym "Green-blind" ; oboInOwl:id "HP:0011521" ; a owl:Class ; rdfs:comment "Blue and red cones only; no functional green cones." ; rdfs:label "Deuteranopia" ; rdfs:subClassOf obo:HP_0000642, obo:HP_0011518 . obo:HP_0011522 obo:IAO_0000115 "Blue and green cones only; no functional red cones." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T07:45:06Z" ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:51445007", "UMLS:C0155015" ; oboInOwl:hasExactSynonym "Red-blind" ; oboInOwl:id "HP:0011522" ; a owl:Class ; rdfs:label "Protanopia" ; rdfs:subClassOf obo:HP_0000642, obo:HP_0011518 . obo:HP_0011523 obo:IAO_0000115 "An iris cyst is composed of a single cell layer of epithelium and is filled with fluid." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:05:29Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:37761009", "UMLS:C0271119" ; oboInOwl:id "HP:0011523" ; a owl:Class ; rdfs:label "Iris cyst" ; rdfs:subClassOf obo:HP_0000525 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011524 obo:IAO_0000115 "Malignant tumor of melanocytes affecting the iris." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:06:41Z" ; oboInOwl:hasDbXref "NCIT:C3224", "SNOMEDCT_US:255012009", "UMLS:C0346373" ; oboInOwl:id "HP:0011524" ; a owl:Class ; rdfs:label "Iris melanoma" ; rdfs:subClassOf obo:HP_0000525, obo:HP_0007716 . obo:HP_0011525 obo:IAO_0000115 "A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:11:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95711003", "UMLS:C0346376" ; oboInOwl:hasExactSynonym "Eye freckle" ; oboInOwl:id "HP:0011525" ; a owl:Class ; rdfs:label "Iris nevus" ; rdfs:subClassOf obo:HP_0000525 . obo:HP_0011526 obo:IAO_0000115 "An abnormal shape of the lens." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:16:11Z" ; oboInOwl:hasDbXref "UMLS:C4023314" ; oboInOwl:hasExactSynonym "Abnormality of lens shape" ; oboInOwl:id "HP:0011526" ; a owl:Class ; rdfs:label "Abnormality of lens shape" ; rdfs:subClassOf obo:HP_0000517 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011527 obo:IAO_0000115 "Exaggerated curvature of the lens of the eye, producing an anterior or posterior spherical bulging." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:17:01Z" ; oboInOwl:hasBroadSynonym "Bulging of eye lens" ; oboInOwl:hasDbXref "SNOMEDCT_US:419281007", "UMLS:C1622439", "UMLS:C4280322" ; oboInOwl:id "HP:0011527" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lentiglobus" ; rdfs:subClassOf obo:HP_0011526 . obo:HP_0011528 obo:IAO_0000115 "Sharply demarcated hyperpigmentation which is congenital found in around 3-5% of the population and of no functional significance." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:24:44Z" ; oboInOwl:hasDbXref "UMLS:C4021145" ; oboInOwl:hasExactSynonym "Single isolated CHRPE", "Single isolated congenital hypertrophy of retinal pigment epithelium" ; oboInOwl:id "HP:0011528" ; a owl:Class ; rdfs:label "Solitary congenital hypertrophy of retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0007649 . obo:HP_0011529 obo:IAO_0000115 "Sharply demarcated hyperpigmentation which is congenital." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:25:33Z" ; oboInOwl:hasDbXref "UMLS:C4021144" ; oboInOwl:hasExactSynonym "Multiple bilateral CHRPE" ; oboInOwl:id "HP:0011529" ; a owl:Class ; rdfs:comment "Bilateral multiple CHRPE is strongly associated with familial adenomatous polyposis coli." ; rdfs:label "Multiple bilateral congenital hypertrophy of retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0007649 . obo:HP_0011530 obo:IAO_0000115 "A small break in the retina." ; dcterms:creator ; oboInOwl:creation_date "2012-04-06T09:39:01Z" ; oboInOwl:hasDbXref "MSH:D012167", "SNOMEDCT_US:232003005", "SNOMEDCT_US:302888003", "SNOMEDCT_US:40024006", "SNOMEDCT_US:95690009", "UMLS:C0035321" ; oboInOwl:hasExactSynonym "Retinal holes" ; oboInOwl:id "HP:0011530" ; a owl:Class ; rdfs:comment "A retinal hole can be asymptomatic or can lead to the sudden appearance of many floaters or flashes, blurry, or wavy vision, or of a a dark shadow or curtain in the peripheral visual field." ; rdfs:label "Retinal hole" ; rdfs:subClassOf obo:HP_0011958 . obo:HP_0011531 obo:IAO_0000115 "Inflammation of the vitreous body, characterized by the presence of inflammatory cells and protein exudate in the vitreous cavity." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T08:21:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95802009", "UMLS:C0235812" ; oboInOwl:hasExactSynonym "Hyalitis", "Vitreitis" ; oboInOwl:id "HP:0011531" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Vitritis" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0011532 obo:IAO_0000115 "A type of retinal exudate located in the subretinal space between the sensory retina and the retinal pigment epithelium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T09:21:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:247156002", "UMLS:C0423431" ; oboInOwl:id "HP:0011532" ; a owl:Class ; rdfs:label "Subretinal exudate" ; rdfs:subClassOf obo:HP_0001147 . obo:HP_0011533 obo:IAO_0000115 "The appearance of yellow/white crystalline-like (hence the name) spots in the retina and thickening of the peripheral part of the vitreous." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T09:52:37Z" ; oboInOwl:hasDbXref "MSH:C536677", "UMLS:C1860405" ; oboInOwl:hasExactSynonym "Snowflake retinal degeneration" ; oboInOwl:id "HP:0011533" ; a owl:Class ; rdfs:label "Snowflake vitreoretinal degeneration" ; rdfs:subClassOf obo:HP_0007769, obo:HP_0007773 . obo:HP_0011534 obo:IAO_0000115 "Abnormality of the spatial relationship of the cardiac segments to other components of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:27:48Z" ; oboInOwl:hasDbXref "UMLS:C4023313" ; oboInOwl:id "HP:0011534" ; a owl:Class ; rdfs:label "Abnormal spatial orientation of the cardiac segments" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_0011535 obo:IAO_0000115 "Abnormality of the spatial relationship of the atria to other components of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:31:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:445898001", "UMLS:C2959688" ; oboInOwl:hasExactSynonym "Abnormal location of heart atrium" ; oboInOwl:id "HP:0011535" ; a owl:Class ; rdfs:label "Abnormal atrial arrangement" ; rdfs:subClassOf obo:HP_0005120, obo:HP_0011534 . obo:HP_0011536 obo:IAO_0000115 "Right atrial isomerism is characterized by bilateral triangular, morphologically right atrial, appendages, both joining the atrial chamber along a broad front with internal terminal crest." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:36:52Z" ; oboInOwl:hasDbXref "MSH:D059446", "UMLS:C3178806" ; oboInOwl:id "HP:0011536" ; a owl:Class ; rdfs:label "Right atrial isomerism" ; rdfs:subClassOf obo:HP_0011535, obo:HP_0031855 . obo:HP_0011537 obo:IAO_0000115 "In left atrial isomerism there is a bilateral small finger-shaped morphologically left atrial appendage joining the atrial chamber along a narrow front without an internal terminal crest." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:37:51Z" ; oboInOwl:hasDbXref "EPCC:03.01.05", "ICD-10:Q20.6", "MSH:D059446", "UMLS:C3178807" ; oboInOwl:id "HP:0011537" ; a owl:Class ; rdfs:comment "Left and right hand side atria have left atrial morphology." ; rdfs:label "Left atrial isomerism" ; rdfs:subClassOf obo:HP_0011535, obo:HP_0031854 . obo:HP_0011538 obo:IAO_0000115 "Mirror image atrial arrangement, with morphologic right atrium on the left hand side and morphologic left atrium on the right hand side." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:40:16Z" ; oboInOwl:hasDbXref "EPCC:03.01.03", "Fyler:0150", "Fyler:150", "ICD-10:Q89.3", "UMLS:C4023312" ; oboInOwl:id "HP:0011538" ; a owl:Class ; rdfs:label "Atrial situs inversus" ; rdfs:subClassOf obo:HP_0011535 . obo:HP_0011539 obo:IAO_0000115 "Common atrium without defining morphologic features." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:43:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:448681000", "UMLS:C3164429" ; oboInOwl:hasExactSynonym "Atrial heterotaxy", "Atrial situs ambiguus" ; oboInOwl:id "HP:0011539" ; a owl:Class ; rdfs:label "Atrial situs ambiguous" ; rdfs:subClassOf obo:HP_0011535 . obo:HP_0011540 obo:IAO_0000115 "The essence of the lesion is the combination of discordant atrioventricular and ventriculo-arterial connections. Thus, the morphologically right atrium is connected to a morphologically left ventricle across the mitral valve, with the left ventricle then connected to the pulmonary trunk. The morphologically left atrium is connected to the morphologically right ventricle across the tricuspid valve, with the morphologically right ventricle connected to the aorta." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:48:56Z" ; oboInOwl:hasDbXref "EPCC:01.01.03", "ICD-10:Q20.5", "MSH:C535426", "SNOMEDCT_US:56743000", "SNOMEDCT_US:83799000", "UMLS:C0232301", "UMLS:C0344616" ; oboInOwl:hasRelatedSynonym "L-transposition", "Ventricular inversion" ; oboInOwl:id "HP:0011540" ; a owl:Class ; rdfs:label "Congenitally corrected transposition of the great arteries" ; rdfs:subClassOf obo:HP_0011534, obo:HP_0011603 . obo:HP_0011541 obo:IAO_0000115 "Crossing of the inflow streams of the two ventricles, due to an apparent twisting of the heart about its long axis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:51:57Z" ; oboInOwl:hasDbXref "UMLS:C4023310" ; oboInOwl:id "HP:0011541" ; a owl:Class ; rdfs:label "Criss-cross atrioventricular valves" ; rdfs:subClassOf obo:HP_0011534 . obo:HP_0011542 obo:IAO_0000115 "Criss-cross atrioventricular valves with a rare cardiac malformation characterized by the two ventricles lying one above the other instead of side by side." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:55:06Z" ; oboInOwl:hasDbXref "UMLS:C4023309" ; oboInOwl:id "HP:0011542" ; a owl:Class ; rdfs:label "Criss-cross atrioventricular valves with superior-inferior ventricles" ; rdfs:subClassOf obo:HP_0011541 . obo:HP_0011543 dcterms:creator ; oboInOwl:creation_date "2012-04-07T10:56:21Z" ; oboInOwl:hasDbXref "Fyler:0184", "Fyler:184", "UMLS:C4023308" ; oboInOwl:id "HP:0011543" ; a owl:Class ; rdfs:label "Superior-inferior ventricles without criss-cross atrioventricular valves" ; rdfs:subClassOf obo:HP_0011534 . obo:HP_0011544 dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:20:04Z" ; oboInOwl:hasDbXref "UMLS:C4023307" ; oboInOwl:id "HP:0011544" ; a owl:Class ; rdfs:label "L-looping of the right ventricle" ; rdfs:subClassOf obo:HP_0011534 . obo:HP_0011545 obo:IAO_0000115 "A deviance in the normal connections between two cardiac segements." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:24:25Z" ; oboInOwl:hasDbXref "UMLS:C4023306" ; oboInOwl:hasExactSynonym "Abnormal connexion of the cardiac segments", "Discordant connection of the cardiac segments" ; oboInOwl:id "HP:0011545" ; a owl:Class ; rdfs:label "Abnormal connection of the cardiac segments" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_0011546 obo:IAO_0000115 "An abnormality of the circulatory connection between atria and ventricles." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:27:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253274005", "UMLS:C0344612" ; oboInOwl:hasExactSynonym "Abnormal atrioventricular connexion" ; oboInOwl:id "HP:0011546" ; a owl:Class ; rdfs:label "Abnormal atrioventricular connection" ; rdfs:subClassOf obo:HP_0011545 . obo:HP_0011547 obo:IAO_0000115 "A defect where there is no connection between the left atrium and left ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:30:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253290005", "UMLS:C0344629" ; oboInOwl:hasExactSynonym "Absent left sided atrioventricular connexion" ; oboInOwl:id "HP:0011547" ; a owl:Class ; rdfs:label "Absent left sided atrioventricular connection" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011548 obo:IAO_0000115 "A defect where there is no connection between the right atrium and right ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:30:44Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253285007", "UMLS:C0344624" ; oboInOwl:hasExactSynonym "Absent right sided atrioventricular connexion" ; oboInOwl:id "HP:0011548" ; a owl:Class ; rdfs:label "Absent right sided atrioventricular connection" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011549 dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:31:18Z" ; oboInOwl:hasDbXref "UMLS:C4023305" ; oboInOwl:hasExactSynonym "Univentricular heart with absent left sided atrioventricular connexion" ; oboInOwl:id "HP:0011549" ; a owl:Class ; rdfs:label "Univentricular heart with absent left sided atrioventricular connection" ; rdfs:subClassOf obo:HP_0011547 . obo:HP_0011550 dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:32:09Z" ; oboInOwl:hasDbXref "UMLS:C4023304" ; oboInOwl:id "HP:0011550" ; a owl:Class ; rdfs:label "Biventricular heart with straddling right sided atrioventricular valve and absent left sided atrioventricular connection" ; rdfs:subClassOf obo:HP_0011547 . obo:HP_0011551 dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:32:53Z" ; oboInOwl:hasDbXref "UMLS:C4023303" ; oboInOwl:hasExactSynonym "Right sided atrium to left ventricle and absent left sided atrioventricular connexion" ; oboInOwl:id "HP:0011551" ; a owl:Class ; rdfs:label "Right sided atrium to left ventricle and absent left sided atrioventricular connection" ; rdfs:subClassOf obo:HP_0011547 . obo:HP_0011552 obo:IAO_0000115 "With left or right cardiac isomerism in a biventricular, the atrioventricular connections are perforce ambiguous, in that one of the connections is concordant (e.g., right-sided morphologic right atrium connected to a morphologic right ventricle) and one of the connections is discordant (e.g., left-sided morphologic right atrium connected to a morphologic left ventricle)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:33:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253278008", "UMLS:C0344617" ; oboInOwl:hasExactSynonym "Ambiguous atrioventricular connexion" ; oboInOwl:id "HP:0011552" ; a owl:Class ; rdfs:label "Ambiguous atrioventricular connection" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011553 obo:IAO_0000115 "Connection of the right atrium to the left ventricle and of the left atrium to the right ventricle in a biventricular heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:47:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253277003", "UMLS:C0344615" ; oboInOwl:hasExactSynonym "Discordant atrioventricular connexion" ; oboInOwl:id "HP:0011553" ; a owl:Class ; rdfs:label "Discordant atrioventricular connection" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011554 obo:IAO_0000115 "The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:49:32Z" ; oboInOwl:hasDbXref "EPCC:01.01.14", "ICD-10:Q20.4", "UMLS:C4023302" ; oboInOwl:hasExactSynonym "Double inlet atrioventricular connexion" ; oboInOwl:id "HP:0011554" ; a owl:Class ; rdfs:label "Double inlet atrioventricular connection" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011555 obo:IAO_0000115 "The condition in which both atria are joined to the left ventricle each by its own atrioventricular valve. Usually there is a hypoplastic right ventricle, which may be on the opposite side of the heart as usual." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:53:33Z" ; oboInOwl:hasDbXref "EPCC:01.04.04", "ICD-10:Q20.4", "SNOMEDCT_US:253283000", "UMLS:C0344622" ; oboInOwl:id "HP:0011555" ; a owl:Class ; rdfs:label "Double inlet left ventricle" ; rdfs:subClassOf obo:HP_0001750, obo:HP_0011554 . obo:HP_0011556 obo:IAO_0000115 "The condition in which both atria are joined to the right ventricle each by its own atrioventricular valve. Usually, the left ventricle is hypoplastic." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T11:57:14Z" ; oboInOwl:hasDbXref "EPCC:01.04.03", "ICD-10:Q20.4", "SNOMEDCT_US:253282005", "UMLS:C0344621" ; oboInOwl:id "HP:0011556" ; a owl:Class ; rdfs:label "Double inlet right ventricle" ; rdfs:subClassOf obo:HP_0001750, obo:HP_0011554 . obo:HP_0011557 obo:IAO_0000115 "The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve. The morphology of this ventricle does not allow one to determine if it corresponds to the left or right ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:00:21Z" ; oboInOwl:hasDbXref "UMLS:C4023301" ; oboInOwl:id "HP:0011557" ; a owl:Class ; rdfs:label "Double inlet to single ventricle of indeterminate morphology" ; rdfs:subClassOf obo:HP_0001750, obo:HP_0011554 . obo:HP_0011558 dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:02:03Z" ; oboInOwl:hasDbXref "UMLS:C4023300" ; oboInOwl:id "HP:0011558" ; a owl:Class ; rdfs:label "Double inlet to single ventricle with common atrioventricular orifice" ; rdfs:subClassOf obo:HP_0011557 . obo:HP_0011559 dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:02:15Z" ; oboInOwl:hasDbXref "UMLS:C4023299" ; oboInOwl:id "HP:0011559" ; a owl:Class ; rdfs:label "Double inlet to single ventricle with two atrioventricular valves" ; rdfs:subClassOf obo:HP_0011557 . obo:HP_0011560 obo:IAO_0000115 "A congenital defect with failure to open of the mitral valve orifice." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:04:11Z" ; oboInOwl:hasDbXref "EPCC:06.02.01", "Fyler:0310", "Fyler:310", "ICD-10:Q23.2", "SNOMEDCT_US:23063005", "UMLS:C0344760" ; oboInOwl:hasExactSynonym "Mitral valve atresia" ; oboInOwl:id "HP:0011560" ; a owl:Class ; rdfs:label "Mitral atresia" ; rdfs:subClassOf obo:HP_0001633, obo:HP_0011546 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011561 obo:IAO_0000115 "An atrioventricular valve that empties into both ventricles. The valve overrides the interventricular septum above a ventricular septum defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:09:28Z" ; oboInOwl:hasDbXref "UMLS:C4023298" ; oboInOwl:id "HP:0011561" ; a owl:Class ; rdfs:comment "Straddling and overriding atrioventricular valves usually occur in combination." ; rdfs:label "Overriding atrioventricular valve" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011562 obo:IAO_0000115 "Anomalous insertion of the chordae tendinae or papillary muscles into the contralateral ventricle in the presence of a ventricular septum defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-07T12:13:57Z" ; oboInOwl:hasDbXref "UMLS:C4023297" ; oboInOwl:id "HP:0011562" ; a owl:Class ; rdfs:comment "Straddling and overriding atrioventricular valves usually occur in combination." ; rdfs:label "Straddling atrioventricular valve" ; rdfs:subClassOf obo:HP_0011546 . obo:HP_0011563 obo:IAO_0000115 "An abnormality of the circulatory connection between the ventricles and the pulmonary artery and aorta." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T07:32:38Z" ; oboInOwl:hasDbXref "UMLS:C4023296" ; oboInOwl:hasExactSynonym "Abnormal ventriculo-arterial connection", "Abnormal ventriculoarterial connexion" ; oboInOwl:id "HP:0011563" ; a owl:Class ; rdfs:comment "The cardiac malformations with abnormal ventriculo-arterial connections in situs solitus and atrio-ventricular concordance include the tetralogy of Fallot as well as different forms of double-outlet right ventricle and transposition of the great arteries." ; rdfs:label "Abnormal ventriculoarterial connection" ; rdfs:subClassOf obo:HP_0011545 . obo:HP_0011564 obo:IAO_0000115 "Anomalous mitral valve arcade is diagnosed based on the following features (1) An adequately sized mitral valve orifice; (2) short, thick, and poorly differentiated chordae with direct union of the papillary muscles to the anterior leaflet; (3) narrow or nearly nonexistent spaces between the abnormal chordae; and (4) greater differentiation of the chordae attached to the posterior papillary muscle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:03:28Z" ; oboInOwl:hasDbXref "UMLS:C4021143" ; oboInOwl:hasExactSynonym "Hammock mitral valve" ; oboInOwl:id "HP:0011564" ; a owl:Class ; rdfs:label "Mitral valve arcade" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0011565 obo:IAO_0000115 "Complete absence of the interatrial septum with common atrioventricular valve and two atrioventricular connections." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T07:50:05Z" ; oboInOwl:hasDbXref "Fyler:1140", "ICD-10:Q21.2", "SNOMEDCT_US:253276007", "UMLS:C0392482" ; oboInOwl:hasExactSynonym "Single atrium" ; oboInOwl:id "HP:0011565" ; a owl:Class ; rdfs:label "Common atrium" ; rdfs:subClassOf obo:HP_0005120 . obo:HP_0011566 obo:IAO_0000115 "A congenital anomaly with partitioning of the right atrium to form a triatrial heart caused by persistence of the right valve of the sinus venosus. Typically, the right atrial partition is due to exaggerated fetal eustachian and thebesian valves, which together form an incomplete septum across the lower part of the atrium. This septum may range from a reticulum to a substantial sheet of tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:02:56Z" ; oboInOwl:hasDbXref "Fyler:2854", "SNOMEDCT_US:274947007", "UMLS:C0344697" ; oboInOwl:hasExactSynonym "Cor triatriatum dextrum" ; oboInOwl:id "HP:0011566" ; a owl:Class ; rdfs:comment "Cor triatriatum dexter is a Latin phrase meaning that the heart (cor) has three atria (triatriatum) whereby the 'third' atrium is on the right (dexter) side." ; rdfs:label "Cor triatriatum dexter" ; rdfs:subClassOf obo:HP_0010774 . obo:HP_0011567 obo:IAO_0000115 "An interatrial communication caused by a deficiency of the common wall between the superior vena cava (SVC) and the right-sided pulmonary veins. SVASD is commonly associated with anomalous pulmonary venous connection (APVC) of some or all of the pulmonary veins, which produces additional left-to-right shunting." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:15:24Z" ; oboInOwl:hasDbXref "Fyler:2010", "ICD-10:Q21.1", "MSH:C548009", "SNOMEDCT_US:95268002", "UMLS:C0344730" ; oboInOwl:id "HP:0011567" ; a owl:Class ; rdfs:label "Sinus venosus atrial septal defect" ; rdfs:subClassOf obo:HP_0001631 . obo:HP_0011568 obo:IAO_0000115 "The left atrio-ventricular connection consists of two anatomically distinct orifices separated by accessory fibrous tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:29:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253402005", "UMLS:C0344770" ; oboInOwl:id "HP:0011568" ; a owl:Class ; rdfs:comment "In about 50% of Double orifice mitral valve (DOMV) cases, valvular function is normal, others present with stenosis or regurgitation. In most cases, a larger orifice is accompanied by a small eccentric accessory orifice, and some show duplicated mitral valves. Embryologically, the lesion results from abnormal leaflet fusion and persistence of the left part of the common atrio-ventricular canal." ; rdfs:label "Double orifice mitral valve" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0011569 obo:IAO_0000115 "Cleft in the anterior mitral valve leaflet not associated with an atrioventricular canal defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:40:46Z" ; oboInOwl:hasDbXref "UMLS:C4023295" ; oboInOwl:id "HP:0011569" ; a owl:Class ; rdfs:label "Cleft anterior mitral valve leaflet" ; rdfs:subClassOf obo:HP_0031480 . obo:HP_0011570 obo:IAO_0000115 "Mitral stenosis with congenital onset." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:46:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:82458004", "UMLS:C0158618" ; oboInOwl:id "HP:0011570" ; a owl:Class ; rdfs:label "Congenital mitral stenosis" ; rdfs:subClassOf obo:HP_0001718 . obo:HP_0011571 obo:IAO_0000115 "Abnormality of the mitral valve apparatus, whereby chordae attach to a single papillary muscle or hypoplastic papillary muscles." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:47:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204362007", "UMLS:C0546965" ; oboInOwl:id "HP:0011571" ; a owl:Class ; rdfs:label "Parachute mitral valve" ; rdfs:subClassOf obo:HP_0025523 . obo:HP_0011572 obo:IAO_0000115 "A congenital stenotic mitral valvular anomaly with a ring of tissue above the mitral valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T08:49:07Z" ; oboInOwl:hasDbXref "UMLS:C4021142" ; oboInOwl:hasExactSynonym "Membranous supravalvular mitral stenosis", "Supravalvular mitral ring" ; oboInOwl:id "HP:0011572" ; a owl:Class ; rdfs:label "Supramitral ring" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0011573 obo:IAO_0000115 "Congenital defect characterized by underdevelopment of the tricuspid valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:22:38Z" ; oboInOwl:hasDbXref "Fyler:1720", "UMLS:C4023294" ; oboInOwl:hasExactSynonym "Tricuspid valve hypoplasia", "Underdeveloped tricuspid valve" ; oboInOwl:id "HP:0011573" ; a owl:Class ; rdfs:label "Hypoplastic tricuspid valve" ; rdfs:subClassOf obo:HP_0001702 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011574 obo:IAO_0000115 "An atrioventricular valve that has failed to open (atretic)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:35:25Z" ; oboInOwl:hasDbXref "UMLS:C4023293" ; oboInOwl:hasExactSynonym "Unopened atrioventricular valve" ; oboInOwl:id "HP:0011574" ; a owl:Class ; rdfs:label "Imperforate atrioventricular valve" ; rdfs:subClassOf obo:HP_0006705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001821 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011575 obo:IAO_0000115 "A tricuspid valve that has failed to open." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:37:55Z" ; oboInOwl:hasDbXref "UMLS:C4023292" ; oboInOwl:hasExactSynonym "Unopened tricuspid valve" ; oboInOwl:id "HP:0011575" ; a owl:Class ; rdfs:comment "Imperforate valve is distinct from atretic valve. The hallmark of an imperforate valve is that it provides potential communication between an atrium and a ventricle. It exists as fused valve leaflets usually possessing their own hypoplastic tensor apparatus. The presence of an imperforate valve may have important surgical implications. Imperforate valve is in contrast to atretic valve with an absent atrioventricular connection. The cornerstone of the diagnosis of an imperformate valve is the identification of a thin mobile membrane between an atrium and a ventrile and the recognition of the tensor apparatus of the valve. In most cases the tensor apparatusis hypoplastic and it maynot be possible to delineate it by echocardiography." ; rdfs:label "Imperforate tricuspid valve" ; rdfs:subClassOf obo:HP_0001702, obo:HP_0011574 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001821 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011576 obo:IAO_0000115 "A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and inlet ventricular defect. There is one valve annulus and two valve orifices." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:56:04Z" ; oboInOwl:hasDbXref "Fyler:1121", "UMLS:C4023291" ; oboInOwl:hasExactSynonym "Intermediate atrioventricular septal defect" ; oboInOwl:id "HP:0011576" ; a owl:Class ; rdfs:label "Intermediate atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0006695 . obo:HP_0011577 obo:IAO_0000115 "A specific combination of heart defects including a primum atrial septal defect and cleft anterior mitral valve leaflet. There is not an inlet ventricular septal defect present. There are two valve annuluses and two valve orifices." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:57:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:718216009", "UMLS:C4023290" ; oboInOwl:id "HP:0011577" ; a owl:Class ; rdfs:label "Partial atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0006695 . obo:HP_0011578 obo:IAO_0000115 "A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and an inlet ventricular septal defect. There are two valve annuli and two valve orifices." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:58:47Z" ; oboInOwl:hasDbXref "UMLS:C4023289" ; oboInOwl:id "HP:0011578" ; a owl:Class ; rdfs:label "Transitional atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0006695 . obo:HP_0011579 obo:IAO_0000115 "Anatomic features of unbalanced atrioventricular septal defect (AVSD) include varying amounts of ventricular hypoplasia, as well as malalignment of the atrioventricular junction. In complete AVSD, the common AV valve can be situated either equally over the right and left ventricles (balanced) or unequally over the ventricles (unbalanced)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T11:02:44Z" ; oboInOwl:hasDbXref "UMLS:C3280940" ; oboInOwl:hasExactSynonym "Unbalanced atrioventricular septal defect" ; oboInOwl:id "HP:0011579" ; a owl:Class ; rdfs:label "Unbalanced atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0006695 . obo:HP_0011580 obo:IAO_0000115 "Abnormally short chordae tendineae of the mitral valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T12:01:44Z" ; oboInOwl:hasDbXref "UMLS:C4023288" ; oboInOwl:id "HP:0011580" ; a owl:Class ; rdfs:comment "The chordae tendineae connect the papillary muscles to the tricuspid valve and the mitral valve in the heart." ; rdfs:label "Short chordae tendineae of the mitral valve" ; rdfs:subClassOf obo:HP_0025523 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014851 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011581 obo:IAO_0000115 "A congenital defect of heart development characterized by origin of both pulmonary artery and aorta from the morphological left ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T12:37:48Z" ; oboInOwl:hasDbXref "Fyler:0650", "Fyler:650", "ICD-10:Q20.2", "SNOMEDCT_US:7368005", "UMLS:C0265809" ; oboInOwl:id "HP:0011581" ; a owl:Class ; rdfs:label "Double outlet left ventricle" ; rdfs:subClassOf obo:HP_0001711 . obo:HP_0011582 obo:IAO_0000115 "Displacement of the heart outside the thoracic cavity and into the abdomen." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:10:32Z" ; oboInOwl:hasDbXref "UMLS:C4023287" ; oboInOwl:id "HP:0011582" ; a owl:Class ; rdfs:label "Abdominal ectopia cordis" ; rdfs:subClassOf obo:HP_0001683 . obo:HP_0011583 obo:IAO_0000115 "A type of ectopia cordis with the heart partially in the cervical region and without a defect of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:11:40Z" ; oboInOwl:hasDbXref "UMLS:C4023286" ; oboInOwl:id "HP:0011583" ; a owl:Class ; rdfs:comment "This type of ectopia cordis presumably represents a retention of the heart in its embryonic position in the neck." ; rdfs:label "Cervical ectopia cordis" ; rdfs:subClassOf obo:HP_0001683 . obo:HP_0011584 obo:IAO_0000115 "A type of ectopia cordis with the heart partially in the cervical region with a defect of the superior portion of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:12:42Z" ; oboInOwl:hasDbXref "UMLS:C4023285" ; oboInOwl:id "HP:0011584" ; a owl:Class ; rdfs:label "Thoracocervical ectopia cordis" ; rdfs:subClassOf obo:HP_0001683 . obo:HP_0011585 obo:IAO_0000115 "Congenital malformation of the thoracic wall with partial or total displacement of the heart outside the thoracic cavity. This feature is associated with sternal cleft or absence of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:13:18Z" ; oboInOwl:hasDbXref "UMLS:C4023284" ; oboInOwl:id "HP:0011585" ; a owl:Class ; rdfs:label "Thoracic ectopia cordis" ; rdfs:subClassOf obo:HP_0001683 . obo:HP_0011586 obo:IAO_0000115 "Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and displacement partially into the abdominal cavity." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:13:52Z" ; oboInOwl:hasDbXref "UMLS:C4023283" ; oboInOwl:id "HP:0011586" ; a owl:Class ; rdfs:comment "In many cases, thoracicoabdominal ectopia cordis is characterized by partial absence or cleft of the sternum, deficiency of the anterior diaphragm, deficiency of the diaphragmatic pericardium, midline abdominal wall defect, and congenital intracardiac abnormalities. These five characteristics comprise the pentalogy of Cantrell." ; rdfs:label "Thoracoabdominal ectopia cordis" ; rdfs:subClassOf obo:HP_0001683 . obo:HP_0011587 obo:IAO_0000115 "A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:34:42Z" ; oboInOwl:hasDbXref "UMLS:C4023282" ; oboInOwl:id "HP:0011587" ; a owl:Class ; rdfs:comment "The normal aortic arch crosses the left mainstem bronchus and descends in the left paravertebral gutter. The coronary arteries arise from the aortic sinuses. The first branch of the aorta is normally the right brachiocephalic artery, then the left common carotid artery, then the left subclavian artery. Abnormal branching refers to any deviance from the norm of the origin or course of these branches or the proximal vertebral arteries. An anomaly of the aortic arch that results in complete encirclement of the trachea and oesophagus by vascular structures is a vascular ring." ; rdfs:label "Abnormal branching pattern of the aortic arch" ; rdfs:subClassOf obo:HP_0012303 . obo:HP_0011588 obo:IAO_0000115 "The aortic arch extends into the soft tissues of the neck before turning down into to become the descending aorta." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:37:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253657003", "UMLS:C0345065" ; oboInOwl:id "HP:0011588" ; a owl:Class ; rdfs:label "Cervical aortic arch" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0011589 obo:IAO_0000115 "The left common carotid artery has a common origin with the innominate artery." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:38:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:460890003", "UMLS:C3532020", "UMLS:C4020746", "UMLS:C4021141" ; oboInOwl:hasExactSynonym "Common brachiocephalic trunk" ; oboInOwl:hasRelatedSynonym "Bovine arch", "Ovine arch" ; oboInOwl:id "HP:0011589" ; a owl:Class ; rdfs:comment "Commonly the three great vessels (innominate artery, left common carotid artery, and the left subclavian artery) originate from the arch of the aorta. The second most common variant of aortic arch branching occurs when the left common carotid artery has a common origin with the innominate artery." ; rdfs:label "Common origin of the right brachiocephalic artery and left common carotid artery" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0011590 obo:IAO_0000115 "A conenital abnormality of the aortic arch in which the two embryonic aortc arches form a vascular ring that surrounds the trachea or esophagus and then join to form the descending aorta. Double aortic arch can cause symptoms because of compression of the esophagus (dysphagia, cyanosis while eating) or trachea (stridor)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:46:10Z" ; oboInOwl:hasDbXref "Fyler:2761", "SNOMEDCT_US:10451007", "UMLS:C0265883" ; oboInOwl:id "HP:0011590" ; a owl:Class ; rdfs:label "Double aortic arch" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0011591 dcterms:creator ; oboInOwl:creation_date "2012-04-08T01:57:40Z" ; oboInOwl:hasDbXref "UMLS:C4023281" ; oboInOwl:id "HP:0011591" ; a owl:Class ; rdfs:label "Left aortic arch with cervical origin of the right subclavian artery" ; rdfs:subClassOf obo:HP_0031055 . obo:HP_0011592 obo:IAO_0000115 "The subclavian artery arises from ductus arteriosus. While the ductus arteriosus is patent its blood supply comes from the ductus, hence from the pulmonary artery. After it closes, the blood supply is retrogradely from the vertebral artery via the circle of Willis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:01:39Z" ; oboInOwl:hasDbXref "UMLS:C4023280" ; oboInOwl:id "HP:0011592" ; a owl:Class ; rdfs:label "Left aortic arch with isolated subclavian artery" ; rdfs:subClassOf obo:HP_0031055 . obo:HP_0011593 obo:IAO_0000115 "A patent ductus arteriosus or ductal ligament completes the ring." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:02:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:74561007", "UMLS:C0265885" ; oboInOwl:hasExactSynonym "Kommerell diverticulum" ; oboInOwl:id "HP:0011593" ; a owl:Class ; rdfs:label "Left aortic arch with retroesophageal diverticulum of Kommerell" ; rdfs:subClassOf obo:HP_0031055 . obo:HP_0011594 obo:IAO_0000115 "Aortic arch crosses the right mainstem bronchus. The left carotid artery is the first branch, right carotid artery the second branch and right subclavian artery as the third branch." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:07:10Z" ; oboInOwl:hasDbXref "UMLS:C4023279" ; oboInOwl:id "HP:0011594" ; a owl:Class ; rdfs:label "Right aortic arch with retroesophageal diverticulum of Kommerell" ; rdfs:subClassOf obo:HP_0012020 . obo:HP_0011595 obo:IAO_0000115 "Aortic arch crosses the left mainstem bronchus. The first branch is the right carotid artery, the second branch is the left carotid artery, the third branch is the subclavian artery, the fourth branch is the right subclavian artery arising from the posteromedial aspect of the distal aortic arch and continuing posterior to the esophagus to the right hand side of the body." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:09:39Z" ; oboInOwl:hasDbXref "UMLS:C4023278" ; oboInOwl:id "HP:0011595" ; a owl:Class ; rdfs:label "Left aortic arch with retroesophageal right subclavian artery" ; rdfs:subClassOf obo:HP_0031055 . obo:HP_0011596 obo:IAO_0000115 "The ring may be completed by the ductal ligament." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:10:48Z" ; oboInOwl:hasDbXref "UMLS:C4023277" ; oboInOwl:id "HP:0011596" ; a owl:Class ; rdfs:label "Left aortic arch with right descending aorta and right ductus arteriosus" ; rdfs:subClassOf obo:HP_0031055 . obo:HP_0011597 dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:23:47Z" ; oboInOwl:hasDbXref "UMLS:C4023276" ; oboInOwl:id "HP:0011597" ; a owl:Class ; rdfs:label "Right aortic arch with left descending aorta and left ductus arteriosus" ; rdfs:subClassOf obo:HP_0012020 . obo:HP_0011598 dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:27:16Z" ; oboInOwl:hasDbXref "UMLS:C4021140" ; oboInOwl:hasExactSynonym "Right aortic arch with aberrant left subclavian artery", "Right aortic arch with anomalous left subclavian artery" ; oboInOwl:id "HP:0011598" ; a owl:Class ; rdfs:label "Right aortic arch with retroesophageal left subclavian artery" ; rdfs:subClassOf obo:HP_0012020 . obo:HP_0011599 obo:IAO_0000115 "Mesocardia is an abnormal location of the heart in which the heart is in a midline position and the longitudinal axis of the heart lies in the mid-sagittal plane." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:41:36Z" ; oboInOwl:hasDbXref "Fyler:0140", "Fyler:140", "SNOMEDCT_US:16567006", "UMLS:C0265865" ; oboInOwl:id "HP:0011599" ; a owl:Class ; rdfs:label "Mesocardia" ; rdfs:subClassOf obo:HP_0004307 . obo:HP_0011600 obo:IAO_0000115 "Abnormal plane of direction of the heart from the base to the apex. Left sided is normal." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4023275" ; oboInOwl:id "HP:0011600" ; a owl:Class ; rdfs:label "Abnormal direction of ventricular apex" ; rdfs:subClassOf obo:HP_0004307 . obo:HP_0011601 obo:IAO_0000115 "Abnormal plane of direction of the heart from the base to the apex towards the right. Left sided is normal." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:46:32Z" ; oboInOwl:hasDbXref "UMLS:C4023274" ; oboInOwl:id "HP:0011601" ; a owl:Class ; rdfs:label "Rightward direction of ventricular apex" ; rdfs:subClassOf obo:HP_0011600 . obo:HP_0011602 obo:IAO_0000115 "Abnormal plane of direction of the heart from the base to the apex in the midline. Left sided is normal." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:47:52Z" ; oboInOwl:hasDbXref "UMLS:C4023273" ; oboInOwl:id "HP:0011602" ; a owl:Class ; rdfs:label "Midline direction of ventricular apex" ; rdfs:subClassOf obo:HP_0011600 . obo:HP_0011603 obo:IAO_0000115 "Defect or defects of the morphogenesis of the aorta and pulmonary arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:51:09Z" ; oboInOwl:hasDbXref "UMLS:C0478012" ; oboInOwl:id "HP:0011603" ; a owl:Class ; rdfs:label "Congenital malformation of the great arteries" ; rdfs:subClassOf obo:HP_0030962 . obo:HP_0011604 obo:IAO_0000115 "A congenital anomaly with an abnormal connection between the aorta and the main pulmonary artery resulting in an aortopulmonary shunt." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:52:38Z" ; oboInOwl:hasDbXref "Fyler:0560", "Fyler:560", "MSH:D001028", "SNOMEDCT_US:17024001", "UMLS:C0003516" ; oboInOwl:id "HP:0011604" ; a owl:Class ; rdfs:label "Aortopulmonary window" ; rdfs:subClassOf obo:HP_0011603 . obo:HP_0011605 obo:IAO_0000115 "A congenitally corrected transposition of the great arteries with a ventricular septal defect: a hole between the two bottom chambers (ventricles) of the heart. The ventricular septal defect is centered around the most superior aspect of the ventricular septum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T02:55:06Z" ; oboInOwl:hasDbXref "UMLS:C4023272" ; oboInOwl:hasExactSynonym "CCTGA", "ccTGA" ; oboInOwl:id "HP:0011605" ; a owl:Class ; rdfs:label "Congenitally corrected transposition of the great arteries with ventricular septal defect" ; rdfs:subClassOf obo:HP_0011540 . obo:HP_0011606 oboInOwl:consider "HP:0001669" ; oboInOwl:id "HP:0011606" ; a owl:Class ; rdfs:label "obsolete Transposition of the great arteries with intact ventricular septum" ; owl:deprecated true . obo:HP_0011607 oboInOwl:consider "HP:0001669" ; oboInOwl:id "HP:0011607" ; a owl:Class ; rdfs:label "obsolete Transposition of the great arteries with ventricular septal defect" ; owl:deprecated true . obo:HP_0011608 obo:IAO_0000115 "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with each pulmonary artery arising separate from each other on the posterior or lateral aspect of the truncus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:03:51Z" ; oboInOwl:hasDbXref "Fyler:0520", "Fyler:520", "UMLS:C4021137" ; oboInOwl:hasExactSynonym "Persistent truncus arteriosus type II", "Type 2 truncus arteriosus" ; oboInOwl:id "HP:0011608" ; a owl:Class ; rdfs:comment "According to the Van Praagh classification (PMID:2856609). The Van Praagh classification additionally specifies the presence (subtype A) or absence (subtype B) of a ventricular septal defect." ; rdfs:label "Type II truncus arteriosus" ; rdfs:subClassOf obo:HP_0001660 . obo:HP_0011609 obo:IAO_0000115 "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby one of the two pulmonary artery branched does not arise from the common pulmonary trunk, but instead from the ductus arteriosus or directly from the aorta." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:08:53Z" ; oboInOwl:hasDbXref "Fyler:0530", "Fyler:530", "UMLS:C4021136" ; oboInOwl:hasExactSynonym "Persistent truncus arteriosus type III", "Type 3 truncus arteriosus" ; oboInOwl:id "HP:0011609" ; a owl:Class ; rdfs:comment "According to the Van Praagh classification (PMID:2856609). The Van Praagh classification additionally specifies the presence (subtype A) or absence (subtype B) of a ventricular septal defect." ; rdfs:label "Type III truncus arteriosus" ; rdfs:subClassOf obo:HP_0001660 . obo:HP_0011610 obo:IAO_0000115 "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby the aortic arch is hypoplastic or interrupted, and a large patent ductus arteriosus is present." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:11:07Z" ; oboInOwl:hasDbXref "Fyler:0540", "Fyler:540", "UMLS:C4021135" ; oboInOwl:hasExactSynonym "Persistent truncus arteriosus type IV", "Type 4 truncus arteriosus" ; oboInOwl:id "HP:0011610" ; a owl:Class ; rdfs:comment "According to the Van Praagh classification (PMID:2856609). The Van Praagh classification additionally specifies the presence (subtype A) or absence (subtype B) of a ventricular septal defect." ; rdfs:label "Type IV truncus arteriosus" ; rdfs:subClassOf obo:HP_0001660 . obo:HP_0011611 obo:IAO_0000115 "Non-continuity of the arch of aorta with an atretic point or absent segment." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:17:10Z" ; oboInOwl:hasAlternativeId "HP:0006680" ; oboInOwl:hasDbXref "Fyler:1241", "Fyler:1250", "SNOMEDCT_US:218728005", "UMLS:C0152419" ; oboInOwl:hasExactSynonym "Atretic transverse aortic arch" ; oboInOwl:hasRelatedSynonym "Aortic arch obstruction" ; oboInOwl:id "HP:0011611" ; a owl:Class ; rdfs:label "Interrupted aortic arch" ; rdfs:subClassOf obo:HP_0012303 . obo:HP_0011612 obo:IAO_0000115 "Non-continuity of the aortic arch with an atretic point or absent segment at the level of the isthmus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:18:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253681005", "UMLS:C0345092" ; oboInOwl:id "HP:0011612" ; a owl:Class ; rdfs:label "Interrupted aortic arch type A" ; rdfs:subClassOf obo:HP_0011611 . obo:HP_0011613 obo:IAO_0000115 "Non-continuity of the aortic arch with an atretic point or absent segment between the left carotid and subclavian arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:18:58Z" ; oboInOwl:hasDbXref "Fyler:1252", "SNOMEDCT_US:253682003", "UMLS:C0345093" ; oboInOwl:hasExactSynonym "Interrupted aortic arch, type b" ; oboInOwl:id "HP:0011613" ; a owl:Class ; rdfs:label "Interrupted aortic arch type B" ; rdfs:subClassOf obo:HP_0011611 . obo:HP_0011614 obo:IAO_0000115 "Non-continuity of the aortic arch with an atretic point or absent segment between the innominate and left carotid arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T03:19:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253683008", "UMLS:C0345094" ; oboInOwl:id "HP:0011614" ; a owl:Class ; rdfs:label "Interrupted aortic arch type C" ; rdfs:subClassOf obo:HP_0011611 . obo:HP_0011615 obo:IAO_0000115 "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:20:13Z" ; oboInOwl:hasDbXref "UMLS:C4023271" ; oboInOwl:hasExactSynonym "Abnormality of pulmonary situs" ; oboInOwl:id "HP:0011615" ; a owl:Class ; rdfs:label "Abnormal pulmonary situs morphology" ; rdfs:subClassOf obo:HP_4000059 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000170 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011616 obo:IAO_0000115 "Mirror image arrangement of the mainstem bronchi with the right pulmonary artery posterior to the right upper lobe bronchus and the left pulmonary artery anterior to the left upper lobe bronchus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:23:21Z" ; oboInOwl:hasDbXref "UMLS:C4023270" ; oboInOwl:id "HP:0011616" ; a owl:Class ; rdfs:label "Pulmonary situs inversus" ; rdfs:subClassOf obo:HP_0011615 . obo:HP_0011617 obo:IAO_0000115 "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which the morphology of both left and right lungs is the same." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:24:21Z" ; oboInOwl:hasDbXref "UMLS:C4023269" ; oboInOwl:id "HP:0011617" ; a owl:Class ; rdfs:label "Pulmonary situs ambiguus" ; rdfs:subClassOf obo:HP_0011615 . obo:HP_0011618 obo:IAO_0000115 "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a right lung." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:25:35Z" ; oboInOwl:hasDbXref "UMLS:C4023268" ; oboInOwl:id "HP:0011618" ; a owl:Class ; rdfs:label "Pulmonary situs ambiguus with bilateral morphologic right lungs" ; rdfs:subClassOf obo:HP_0011617 . obo:HP_0011619 obo:IAO_0000115 "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a left lung." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:26:18Z" ; oboInOwl:hasDbXref "UMLS:C4023267" ; oboInOwl:id "HP:0011619" ; a owl:Class ; rdfs:label "Pulmonary situs ambiguus with bilateral morphologic left lungs" ; rdfs:subClassOf obo:HP_0011617 . obo:HP_0011620 obo:IAO_0000115 "An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:30:05Z" ; oboInOwl:hasDbXref "UMLS:C4023266" ; oboInOwl:id "HP:0011620" ; a owl:Class ; rdfs:label "Abnormality of abdominal situs" ; rdfs:subClassOf obo:HP_0002012, obo:HP_0030853 . obo:HP_0011621 obo:IAO_0000115 "A type of ventricular septal defect communicating directly between the left ventricle and right atrium. This is anatomically possible because the normal tricuspid valve is more apically displaced than the mitral valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:34:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:41893002", "UMLS:C0265812", "UMLS:C4023265" ; oboInOwl:hasRelatedSynonym "Left ventricular - right atrial communication" ; oboInOwl:id "HP:0011621" ; a owl:Class ; rdfs:comment "Echocardiography may visualize a jet across a small defect between left ventricle and right atrium." ; rdfs:label "Gerbode ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011622 obo:IAO_0000115 "A ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:38:29Z" ; oboInOwl:hasDbXref "Fyler:1340" ; oboInOwl:hasExactSynonym "Atrioventricular canal type ventricular septal defect", "Type 3 ventricular septal defect" ; oboInOwl:id "HP:0011622" ; a owl:Class ; rdfs:comment "The muscular septum is a nonplanar structure that can be divided into inlet, trabecular, and infundibular components. The inlet portion is inferioposterior to the membranous septum. It begins at the level of the atrioventricular valves and ends at their chordal attachments apically." ; rdfs:label "Inlet ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011623 obo:IAO_0000115 "The trabecular septum is the largest part of the interventricular septum. It extends from the membranous septum to the apex and superiorly to the infundibular septum. A defect in the trabecular septum is called muscular VSD if the defect is completely rimmed by muscle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:43:15Z" ; oboInOwl:hasDbXref "Fyler:1320", "SNOMEDCT_US:94706008", "UMLS:C0685707" ; oboInOwl:hasExactSynonym "Type 4 ventricular septal defect" ; oboInOwl:hasRelatedSynonym "Ventricular septal defect, muscular" ; oboInOwl:id "HP:0011623" ; a owl:Class ; rdfs:label "Muscular ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011624 obo:IAO_0000115 "A muscular ventricular septal defect located at the apex of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:45:43Z" ; oboInOwl:hasDbXref "UMLS:C4023264" ; oboInOwl:id "HP:0011624" ; a owl:Class ; rdfs:label "Apical muscular ventricular septal defect" ; rdfs:subClassOf obo:HP_0011623 . obo:HP_0011625 obo:IAO_0000115 "A type of muscular ventricular septal defect characterized by the presence of multiple small defects in the ventricular septum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:49:03Z" ; oboInOwl:hasDbXref "UMLS:C4023263" ; oboInOwl:hasExactSynonym "Swiss cheese ventricular septal defect" ; oboInOwl:id "HP:0011625" ; a owl:Class ; rdfs:label "Multiple muscular ventricular septal defects" ; rdfs:subClassOf obo:HP_0011623 . obo:HP_0011626 obo:IAO_0000115 "Right pulmonary venous return to the inferior vena cava." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T09:57:11Z" ; oboInOwl:hasDbXref "ICD-10:Q26.8", "MSH:D012587", "SNOMEDCT_US:111323005", "SNOMEDCT_US:39905002", "UMLS:C0036400" ; oboInOwl:hasExactSynonym "Pulmonary venolobar syndrome", "Scimitar syndrome" ; oboInOwl:id "HP:0011626" ; a owl:Class ; rdfs:label "Scimitar anomaly" ; rdfs:subClassOf obo:HP_0010773 . obo:HP_0011627 obo:IAO_0000115 "Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinotubular junction to the cavity of the left, or (less commonly) right ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:29:49Z" ; oboInOwl:hasDbXref "UMLS:C4023262" ; oboInOwl:id "HP:0011627" ; a owl:Class ; rdfs:label "Aorto-ventricular tunnel" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0011628 obo:IAO_0000115 "A developmental defect of the pericardium with congenital onset." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:05:20Z" ; oboInOwl:hasDbXref "UMLS:C4023261" ; oboInOwl:id "HP:0011628" ; a owl:Class ; rdfs:label "Congenital defect of the pericardium" ; rdfs:subClassOf obo:HP_0001697 . obo:HP_0011629 obo:IAO_0000115 "No pericardium around the heart, occurring as a congenital defect, not the result of a surgical pericardectomy." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:06:22Z" ; oboInOwl:hasDbXref "Fyler:1910", "SNOMEDCT_US:253732001", "UMLS:C0345140" ; oboInOwl:hasExactSynonym "Absent pericardium", "Congenital absence of the pericardium" ; oboInOwl:id "HP:0011629" ; a owl:Class ; rdfs:label "Total absence of the pericardium" ; rdfs:subClassOf obo:HP_0011628 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011630 obo:IAO_0000115 "No pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:06:57Z" ; oboInOwl:hasDbXref "UMLS:C4023259" ; oboInOwl:id "HP:0011630" ; a owl:Class ; rdfs:label "Complete diaphragmatic absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011631 obo:IAO_0000115 "No pericardium is present on the righthand side of the heart. It is a congenital absence of pericardium rather than the result of a pericardectomy." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:08:42Z" ; oboInOwl:hasDbXref "UMLS:C4023258" ; oboInOwl:id "HP:0011631" ; a owl:Class ; rdfs:label "Complete right sided absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011632 obo:IAO_0000115 "A congenital anomaly with lack of part of the pericardium on the righthand side of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:09:24Z" ; oboInOwl:hasDbXref "UMLS:C4023257" ; oboInOwl:id "HP:0011632" ; a owl:Class ; rdfs:comment "A congenital anomaly and not the result of a pericardectomy." ; rdfs:label "Partial right sided absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011633 obo:IAO_0000115 "A congenital anomaly with complete lack of the pericardium on the lefthand side of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:11:03Z" ; oboInOwl:hasDbXref "UMLS:C4023256" ; oboInOwl:hasExactSynonym "Absent lining around of left side of heart" ; oboInOwl:id "HP:0011633" ; a owl:Class ; rdfs:comment "A congenital anomaly and not the result of a pericardectomy." ; rdfs:label "Complete left sided absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011634 obo:IAO_0000115 "A congenital anomaly with lack of part of the pericardium on the lefthand side of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:11:59Z" ; oboInOwl:hasDbXref "UMLS:C4023255" ; oboInOwl:id "HP:0011634" ; a owl:Class ; rdfs:comment "A congenital anomaly and not the result of a pericardectomy." ; rdfs:label "Partial left sided absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011635 obo:IAO_0000115 "Lack of a part of the pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-08T10:13:04Z" ; oboInOwl:hasDbXref "UMLS:C4023254" ; oboInOwl:id "HP:0011635" ; a owl:Class ; rdfs:label "Partial diaphragmatic absence of pericardium" ; rdfs:subClassOf obo:HP_0011628 . obo:HP_0011636 obo:IAO_0000115 "Isolated abnormalities of the coronary artery origins. This may be in associated with other structural heart malformations but not the patterns of complex structural heart malformations which result in abnormal course of the coronary arteries." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:32:24Z" ; oboInOwl:hasDbXref "UMLS:C4023253" ; oboInOwl:id "HP:0011636" ; a owl:Class ; rdfs:label "Abnormal coronary artery origin" ; rdfs:subClassOf obo:HP_0006704 . obo:HP_0011637 obo:IAO_0000115 "A coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:33:57Z" ; oboInOwl:hasDbXref "UMLS:C4023252" ; oboInOwl:id "HP:0011637" ; a owl:Class ; rdfs:label "Anomalous origin of coronary artery from the pulmonary artery" ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0011638 obo:IAO_0000115 "Left main coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the left cusp of the aortic valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:40:53Z" ; oboInOwl:hasDbXref "Fyler:3101", "SNOMEDCT_US:450301003", "UMLS:C3472166" ; oboInOwl:hasExactSynonym "ALCAPA", "Anomalous left coronary artery from the pulmonary artery", "Bland-Garland-White syndrome" ; oboInOwl:id "HP:0011638" ; a owl:Class ; rdfs:comment "In this anomaly the function of the LMCA territory often requires extensive collateral formation from the RCA, which is often dilated. In the first month of life, physiologic pulmonary hypertension tends to preserve anterograde flow within the left coronary artery, and infants are usually asymptomatic. As pulmonary pressure drops, left-to-right shunting from the higher pressure left coronary arterial system to the lower pressure pulmonary arterial system occurs, and patients become symptomatic. Imaging findings may include markedly dilated collateral arteries and coronary veins." ; rdfs:label "Anomalous origin of left coronary artery from the pulmonary artery" ; rdfs:subClassOf obo:HP_0011637 . obo:HP_0011639 obo:IAO_0000115 "Right coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the right cusp of the aortic valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:41:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:450300002", "UMLS:C3472165" ; oboInOwl:id "HP:0011639" ; a owl:Class ; rdfs:label "Anomalous origin of right coronary artery from the pulmonary artery" ; rdfs:subClassOf obo:HP_0011637 . obo:HP_0011640 obo:IAO_0000115 "The presence of a single coronary artery ostium from which both coronary arteries arise." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:44:38Z" ; oboInOwl:hasDbXref "UMLS:C4023251" ; oboInOwl:id "HP:0011640" ; a owl:Class ; rdfs:label "Single coronary artery origin" ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0011641 obo:IAO_0000115 "A congenital malformation with abnormal connection between one of the coronary arteries and a heart chamber or another blood vessel." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T08:54:51Z" ; oboInOwl:hasDbXref "Fyler:2230", "SNOMEDCT_US:373093003", "UMLS:C0265898" ; oboInOwl:hasExactSynonym "Coronary fistula" ; oboInOwl:id "HP:0011641" ; a owl:Class ; rdfs:comment "Coronary artery fistulas are congenital malformations. This term does not apply to surgical fistulas." ; rdfs:label "Coronary artery fistula" ; rdfs:subClassOf obo:HP_0011686 . obo:HP_0011642 obo:IAO_0000115 "An abnormality of the coronary sinus, which is formed by the union of the great cardiac vein and the left marginal vein and terminates in the right atrium. The coronary sinus functions to o collect deoxygenated blood from the myocardium of the heart and drain it into the right atrium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:02:09Z" ; oboInOwl:hasDbXref "Fyler:2840", "SNOMEDCT_US:253323000", "UMLS:C0344680" ; oboInOwl:hasExactSynonym "Abnormality of the coronary sinus" ; oboInOwl:id "HP:0011642" ; a owl:Class ; rdfs:label "Abnormal coronary sinus morphology" ; rdfs:subClassOf obo:HP_0005120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011643 obo:IAO_0000115 "An atrial septal defect characterized by a deficiency in the tissue separating the coronary sinus from the left atrium (LA). This results in partial or complete unroofing of the coronary sinus leading to a predominantly left-to-right shunt through the coronary sinus (LA to coronary sinus to right atrium [RA]). The orifice of the ostium is frequently large because of the increased flow. From the RA side, the defect is located at the level of the coronary sinus ostium and may also include some deficiency in atrial tissue around the ostium. From the LA side, the size can be variable depending on the degree of unroofing of the coronary sinus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:07:42Z" ; oboInOwl:hasDbXref "ICD-10:Q21.1", "UMLS:C2063331" ; oboInOwl:id "HP:0011643" ; a owl:Class ; rdfs:label "Coronary sinus atrial septal defect" ; rdfs:subClassOf obo:HP_0011642 . obo:HP_0011644 obo:IAO_0000115 "A venous pouch within the left ventricular wall, with a neck opening into the coronary sinus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:12:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:447661004", "UMLS:C3163894" ; oboInOwl:hasExactSynonym "Diverticulum of the coronary sinus" ; oboInOwl:id "HP:0011644" ; a owl:Class ; rdfs:label "Coronary sinus diverticulum" ; rdfs:subClassOf obo:HP_0011642 . obo:HP_0011645 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation of one of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:31:57Z" ; oboInOwl:hasDbXref "Fyler:2316", "SNOMEDCT_US:54160000", "UMLS:C2239253" ; oboInOwl:hasExactSynonym "Aortic sinus aneurysm" ; oboInOwl:hasNarrowSynonym "Aneurysm of the aortic sinus", "Sinus of Valsalva aneurysm" ; oboInOwl:id "HP:0011645" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of the sinus of Valsalva" ; rdfs:subClassOf obo:HP_0004970 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002093 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011646 obo:IAO_0000115 "Narrowing or constriction of the aorta localized at the insertion of the ductus arteriosus, i.e., to the juxtaductal region of aortic arch." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:41:05Z" ; oboInOwl:hasDbXref "UMLS:C4023250" ; oboInOwl:id "HP:0011646" ; a owl:Class ; rdfs:comment "Juxtaductal coarctation usually presents when the ductus arteriosus closes." ; rdfs:label "Juxtaductal coarctation of the aorta" ; rdfs:subClassOf obo:HP_0012305 . obo:HP_0011647 obo:IAO_0000115 "Narrowing or constriction of the aorta localized distal to the ductus arteriosus, i.e., to the postductal region of aortic arch." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:49:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:72242008", "UMLS:C0265879" ; oboInOwl:hasExactSynonym "Postductal aortic coarctation" ; oboInOwl:id "HP:0011647" ; a owl:Class ; rdfs:comment "Blood flow to the aorta distal to the coarctation may be dependent on a patent ductus arteriosus, and hence closure of the ductus arteriosus can lead to serious ischemia of the affected tissues." ; rdfs:label "Postductal coarctation of the aorta" ; rdfs:subClassOf obo:HP_0012305 . obo:HP_0011648 obo:IAO_0000115 "Abnormal persistent patency of the ductus arteriosus in postnatal life when birth was at 37 completed weeks of gestation or greater." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:58:35Z" ; oboInOwl:hasDbXref "UMLS:C4023249" ; oboInOwl:id "HP:0011648" ; a owl:Class ; rdfs:label "Patent ductus arteriosus after birth at term" ; rdfs:subClassOf obo:HP_0001643 . obo:HP_0011649 obo:IAO_0000115 "Abnormal persistent patency of the ductus arteriosus when birth was at less than 37 weeks completed gestation." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T09:59:59Z" ; oboInOwl:hasDbXref "UMLS:C4023248" ; oboInOwl:id "HP:0011649" ; a owl:Class ; rdfs:label "Patent ductus arteriosus after premature birth" ; rdfs:subClassOf obo:HP_0001643 . obo:HP_0011650 obo:IAO_0000115 "The presence of both a left and a right ductus arteriosus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:00:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:461093009", "UMLS:C0431501" ; oboInOwl:hasExactSynonym "Bilateral ductus botalli" ; oboInOwl:id "HP:0011650" ; a owl:Class ; rdfs:label "Bilateral ductus arteriosus" ; rdfs:subClassOf obo:HP_0001643 . obo:HP_0011651 obo:IAO_0000115 "A double outlet right ventricle with a subaortic ventricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:02:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:448516008", "UMLS:C3165091" ; oboInOwl:hasExactSynonym "DORV with doubly committed VSD and pulmonary stenosis" ; oboInOwl:id "HP:0011651" ; a owl:Class ; rdfs:label "Double outlet right ventricle with doubly committed ventricular septal defect and pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011652 obo:IAO_0000115 "A double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:05:46Z" ; oboInOwl:hasDbXref "Fyler:0604", "Fyler:604", "UMLS:C4023247" ; oboInOwl:hasExactSynonym "DORV with doubly committed VSD", "Double outlet right ventricle, doubly committed ventricular septal defect" ; oboInOwl:id "HP:0011652" ; a owl:Class ; rdfs:label "Double outlet right ventricle with doubly committed ventricular septal defect without pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011653 obo:IAO_0000115 "A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, and also has a pulmonary stenosis; abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:06:15Z" ; oboInOwl:hasDbXref "UMLS:C4023246" ; oboInOwl:hasExactSynonym "DORV with non-committed VSD and pulmonary stenosis" ; oboInOwl:id "HP:0011653" ; a owl:Class ; rdfs:label "Double outlet right ventricle with non-committed ventricular septal defect and pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011654 obo:IAO_0000115 "A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, but there is not accompanying pulmonary stenosis; the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:06:32Z" ; oboInOwl:hasDbXref "Fyler:0603", "Fyler:603", "UMLS:C4023245" ; oboInOwl:hasExactSynonym "DORV with non-committed VSD without pulmonary stenosis", "Double outlet right ventricle, noncommitted ventricular septal defect" ; oboInOwl:id "HP:0011654" ; a owl:Class ; rdfs:label "Double outlet right ventricle with non-committed ventricular septal defect without pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011655 obo:IAO_0000115 "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:06:46Z" ; oboInOwl:hasDbXref "UMLS:C4023244" ; oboInOwl:hasExactSynonym "DORV with subaortic VSD and pulmonary stenosis" ; oboInOwl:id "HP:0011655" ; a owl:Class ; rdfs:label "Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011656 obo:IAO_0000115 "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:07:00Z" ; oboInOwl:hasDbXref "UMLS:C4023243" ; oboInOwl:hasExactSynonym "DORV with subaortic VSD without pulmonary stenosis" ; oboInOwl:id "HP:0011656" ; a owl:Class ; rdfs:label "Double outlet right ventricle with subaortic ventricular septal defect without pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011657 obo:IAO_0000115 "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:07:16Z" ; oboInOwl:hasDbXref "UMLS:C4023242" ; oboInOwl:hasExactSynonym "DORV with subpulmonary VSD and pulmonary stenosis" ; oboInOwl:id "HP:0011657" ; a owl:Class ; rdfs:label "Double outlet right ventricle with subpulmonary ventricular septal defect and pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011658 obo:IAO_0000115 "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:07:31Z" ; oboInOwl:hasDbXref "UMLS:C4023241" ; oboInOwl:hasExactSynonym "DORV with subpulmonary VSD without pulmonary stenosis", "Taussig-Bing anomaly" ; oboInOwl:id "HP:0011658" ; a owl:Class ; rdfs:label "Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001719 . obo:HP_0011659 obo:IAO_0000115 "Features of tetralogy of Fallot with either rudimentary ridges or the complete absence of pulmonic valve tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:15:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:399228007", "UMLS:C1302264" ; oboInOwl:hasExactSynonym "Tetralogy of Fallot with absent pulmonary valve syndrome" ; oboInOwl:id "HP:0011659" ; a owl:Class ; rdfs:label "Tetralogy of Fallot with absent pulmonary valve" ; rdfs:subClassOf obo:HP_0001636, obo:HP_0005134 . obo:HP_0011660 obo:IAO_0000115 "Anomalous origin of one pulmonary artery from the ascending aorta with the contralateral pulmonary artery arising from the right ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:34:29Z" ; oboInOwl:hasDbXref "Fyler:0550", "Fyler:550", "UMLS:C4021134" ; oboInOwl:hasExactSynonym "Hemitruncus" ; oboInOwl:id "HP:0011660" ; a owl:Class ; rdfs:comment "Origin of a pulmonary artery from the aorta is also known as hemitruncus. One pulmonary artery branch, usually the right, arises from the ascending aorta just above the aortic sinuses, while the main pulmonary artery and the other pulmonary branch arise in their normal position from the right ventricle." ; rdfs:label "Anomalous origin of one pulmonary artery from ascending aorta" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0011661 obo:IAO_0000115 "The left pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:42:23Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253637002", "UMLS:C0345040" ; oboInOwl:id "HP:0011661" ; a owl:Class ; rdfs:label "Anomalous origin of left pulmonary artery from ascending aorta" ; rdfs:subClassOf obo:HP_0011660 . obo:HP_0011662 obo:IAO_0000115 "Failure to develop of the tricuspid valve and thus lack of the normal connection between the right atrium and the right ventricle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T10:45:29Z" ; oboInOwl:hasDbXref "EPCC:06.01.01", "Fyler:0400", "Fyler:400", "ICD-10:Q22.4", "MSH:D018785", "SNOMEDCT_US:253455004", "SNOMEDCT_US:63042009", "UMLS:C0243002" ; oboInOwl:hasExactSynonym "Tricuspid valve atresia" ; oboInOwl:id "HP:0011662" ; a owl:Class ; rdfs:label "Tricuspid atresia" ; rdfs:subClassOf obo:HP_0001702 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011663 obo:IAO_0000115 "Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T11:14:59Z" ; oboInOwl:hasDbXref "UMLS:C2063326" ; oboInOwl:hasExactSynonym "Cardiomyopathy, right ventricular" ; oboInOwl:hasRelatedSynonym "Cardiomyopathy, esp. right ventricular" ; oboInOwl:id "HP:0011663" ; a owl:Class ; rdfs:comment "This feature is most often seen in the disease arrhythmogenic right ventricular cardiomyopathy (ARVC). ARVC is defined histologically by the presence of progressive replacement of right ventricular myocardium with adipose and fibrous tissue often confined to a triangle of dysplasia comprising the right ventricular inflow, outflow, and apex. While these pathologic abnormalities can result in functional and morphological right ventricular abnormalities, they also occur in the left ventricle, producing a DCM phenotype, or can be present in the absence of clinically detectable structural changes in either ventricle. For the purposes of this classification, ARVC is defined by the presence of right ventricular dysfunction (global or regional), with or without left ventricular disease, in the presence of histological evidence for the disease and/or electrocardiographic abnormalities in accordance with published criteria." ; rdfs:label "Right ventricular cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638, obo:HP_0001707 . obo:HP_0011664 obo:IAO_0000115 "Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T11:31:40Z" ; oboInOwl:hasDbXref "UMLS:C4021133" ; oboInOwl:hasExactSynonym "Left ventricular non-compaction cardiomyopathy" ; oboInOwl:id "HP:0011664" ; a owl:Class ; rdfs:comment "Left ventricular noncompaction cardiomyopathy (LVNC), also known as spongy myocardium, is a distinct form of cardiomyopathy occurring in-utero when segments of spongy myocardium fail to transform into compact, mature musculature resulting in prominent myocardial trabeculae, deep intra-trabecular recesses, and decreased cardiac function. It has been proposed that LVNC results from arrest of the compaction process during the second month of embryological development." ; rdfs:label "Left ventricular noncompaction cardiomyopathy" ; rdfs:subClassOf obo:HP_0012817 . obo:HP_0011665 obo:IAO_0000115 "Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T11:39:40Z" ; oboInOwl:hasDbXref "MSH:D054549", "SNOMEDCT_US:441541008", "UMLS:C1739395" ; oboInOwl:hasExactSynonym "Broken-heart syndrome" ; oboInOwl:id "HP:0011665" ; a owl:Class ; rdfs:label "Takotsubo cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0011666 obo:IAO_0000115 "Absence of the right superior vena cava (RSVC). An absent RSVC is always associated with a persistent left superior vena cava (PLSVC). During normal fetal development, the left-sided anterior venous cardinal system regresses, leaving the coronary sinus (CS) and the ligament of Marshall. Failure of the closure of the left anterior cardinal vein results in PLSVC. In general, PLSVC is associated with the right superior vena cava (RSVC) and drains into the RA via a dilated CS. When developmental arrest occurs at an earlier stage, the CS is absent and the PLSVC drains into the left atrium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T11:43:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253308005", "UMLS:C0344656" ; oboInOwl:id "HP:0011666" ; a owl:Class ; rdfs:comment "The superior vena cava is formed by the left and right brachiocephalic (innominate) veins, which receive blood from the arms, head and neck." ; rdfs:label "Absent right superior vena cava" ; rdfs:subClassOf obo:HP_0005301 . obo:HP_0011667 dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:00:46Z" ; oboInOwl:hasDbXref "UMLS:C4023240" ; oboInOwl:id "HP:0011667" ; a owl:Class ; rdfs:label "Bilateral superior vena cava with bridging vein" ; rdfs:subClassOf obo:HP_0033379 . obo:HP_0011668 dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:01:33Z" ; oboInOwl:hasDbXref "UMLS:C4023239" ; oboInOwl:id "HP:0011668" ; a owl:Class ; rdfs:label "Bilateral superior vena cava with no bridging vein" ; rdfs:subClassOf obo:HP_0033379 . obo:HP_0011669 obo:IAO_0000115 "A persistent left superior vena cava (PLSVC) that drains into the left atrium instead of the right atrium via the coronary sinus, resulting in a right to left sided shunt." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:02:06Z" ; oboInOwl:hasDbXref "UMLS:C4023238" ; oboInOwl:id "HP:0011669" ; a owl:Class ; rdfs:label "Left superior vena cava draining directly to the left atrium" ; rdfs:subClassOf obo:HP_0033379 . obo:HP_0011670 obo:IAO_0000115 "A persistent left superior vena cava (PLSVC) that drains into the right atrium via the coronary sinus. This is the case in 80-92% of cases of PLSVC and results in no hemodynamic consequence." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:02:58Z" ; oboInOwl:hasDbXref "ICD-10:Q26.1", "UMLS:C2677768" ; oboInOwl:id "HP:0011670" ; a owl:Class ; rdfs:label "Left superior vena cava draining to coronary sinus" ; rdfs:subClassOf obo:HP_0033379 . obo:HP_0011671 obo:IAO_0000115 "Interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:04:06Z" ; oboInOwl:hasDbXref "ICD-10:26.8", "UMLS:C4023237" ; oboInOwl:id "HP:0011671" ; a owl:Class ; rdfs:label "Interrupted inferior vena cava with azygous continuation" ; rdfs:subClassOf obo:HP_0025576 . obo:HP_0011672 obo:IAO_0000115 "A myxoma (tumor of primitive connective tissue) of the heart. Cardiac myxomas consist of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma. Cardiac myxomas are of endocardial origin and general project from the endocardium into a cardiac chamber." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:10:35Z" ; oboInOwl:hasDbXref "NCIT:C6577", "SNOMEDCT_US:426191007", "UMLS:C1960546" ; oboInOwl:id "HP:0011672" ; a owl:Class ; rdfs:label "Cardiac myxoma" ; rdfs:subClassOf obo:HP_0100544 . obo:HP_0011673 obo:IAO_0000115 "Abnormal proliferation of blood vessels within the cardiac cavities attached to the endocardium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:20:13Z" ; oboInOwl:hasDbXref "NCIT:C3085", "UMLS:C1707298" ; oboInOwl:id "HP:0011673" ; a owl:Class ; rdfs:label "Cardiac hemangioma" ; rdfs:subClassOf obo:HP_0410266 . obo:HP_0011674 obo:IAO_0000115 "A teratoma within the heart. Most commonly, these tumors are detected in the pericardial cavity attached to the pulmonary artery and aorta. The tumor size within the heart varies from 2 to 9 cm in diameter, and intrapericardial tumors as large as 15 cm have been reported. Intracardiac tumors arise from the atrial or ventricular wall as nodular masses protruding into the cardiac chambers. Cardiac and pericardial teratomas are easily detected in the fetus and neonate by two-dimensional echocardiography as heterogeneous and encapsulated cystic masses. Histologically, cardiac teratomas contain multiple immature elements including epithelium, neuroglial tissue, thyroid, pancreas, smooth and skeletal muscle, cartilage and bone." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:33:29Z" ; oboInOwl:hasDbXref "NCIT:C3403", "UMLS:C1112387" ; oboInOwl:id "HP:0011674" ; a owl:Class ; rdfs:label "Cardiac teratoma" ; rdfs:subClassOf obo:HP_0009792, obo:HP_0100544 . obo:HP_0011675 obo:IAO_0000115 "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." ; dcterms:creator ; oboInOwl:creation_date "2012-04-09T12:47:32Z" ; oboInOwl:hasAlternativeId "HP:0001656", "HP:0001661", "HP:0001665", "HP:0001666", "HP:0001675", "HP:0001687", "HP:0001721", "HP:0004351", "HP:0005158" ; oboInOwl:hasDbXref "MSH:C562490", "MSH:D001145", "SNOMEDCT_US:102594003", "SNOMEDCT_US:44808001", "SNOMEDCT_US:698247007", "UMLS:C0003811", "UMLS:C0264886", "UMLS:C0522055", "UMLS:C0855329", "UMLS:C1832603", "UMLS:C1842820" ; oboInOwl:hasExactSynonym "Abnormal heart rate", "Arrhythmias", "Cardiac arrhythmia", "Cardiac arrhythmias", "Cardiac rhythm disturbances", "Heart rhythm disorders", "Irregular heart beat", "Irregular heartbeat" ; oboInOwl:id "HP:0011675" ; a owl:Class ; rdfs:label "Arrhythmia" ; rdfs:subClassOf obo:HP_0030956 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001845 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060047 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011676 dcterms:creator ; oboInOwl:creation_date "2012-04-10T07:40:33Z" ; oboInOwl:hasDbXref "UMLS:C4023236" ; oboInOwl:id "HP:0011676" ; a owl:Class ; rdfs:label "Tetralogy of Fallot with absent subarterial conus" ; rdfs:subClassOf obo:HP_0001636 . obo:HP_0011677 dcterms:creator ; oboInOwl:creation_date "2012-04-10T07:41:53Z" ; oboInOwl:hasDbXref "UMLS:C4023235" ; oboInOwl:id "HP:0011677" ; a owl:Class ; rdfs:label "Tetralogy of Fallot with atrioventricular canal defect" ; rdfs:subClassOf obo:HP_0001636 . obo:HP_0011678 obo:IAO_0000115 "A type of tetralogy of Fallot with pulmonary atresia in which all pulmonary blood flow is derived from major aortopulmonary collateral arteries (MAPCA)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T07:43:01Z" ; oboInOwl:hasDbXref "UMLS:C4023234" ; oboInOwl:id "HP:0011678" ; a owl:Class ; rdfs:comment "Major aortopulmonary collateral arteries (MACPAs) are arteries that develop to supply blood to the lungs when native pulmonary circulation is underdeveloped. That is, the blood supply to the lungs derives from the aorta rather than from the pulmonary artery." ; rdfs:label "Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries" ; rdfs:subClassOf obo:HP_0012516 . obo:HP_0011679 obo:IAO_0000115 "The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T07:44:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253512000", "UMLS:C0344881" ; oboInOwl:id "HP:0011679" ; a owl:Class ; rdfs:label "Tetralogy of Fallot with pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001636 . obo:HP_0011680 dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:02:28Z" ; oboInOwl:hasDbXref "UMLS:C4023233" ; oboInOwl:id "HP:0011680" ; a owl:Class ; rdfs:label "Single ventricle of indeterminate morphology" ; rdfs:subClassOf obo:HP_0001750 . obo:HP_0011681 obo:IAO_0000115 "A ventricular septal defect that lies beneath the semilunar valve(s) in the conal or outlet septum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:09:32Z" ; oboInOwl:hasDbXref "Fyler:1330", "SNOMEDCT_US:448876006", "UMLS:C3165130" ; oboInOwl:hasExactSynonym "Conal ventricular septal defect", "Doubly committed ventricular septal defect", "Infundibular ventricular septal defect", "Supracristal ventricular septal defect", "Type 1 ventricular septal defect" ; oboInOwl:id "HP:0011681" ; a owl:Class ; rdfs:label "Subarterial ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011682 obo:IAO_0000115 "A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:21:13Z" ; oboInOwl:hasDbXref "Fyler:1310", "SNOMEDCT_US:109428005", "UMLS:C0344925" ; oboInOwl:hasExactSynonym "Conoventricular ventricular septal defect", "Membranous ventricular septal defect", "Paramembranous ventricular septal defect", "Perimembraneous ventricular septal defect", "Type 2 ventricular septal defect" ; oboInOwl:hasRelatedSynonym "Ventricular septal defect, perimembranous" ; oboInOwl:id "HP:0011682" ; a owl:Class ; rdfs:label "Perimembranous ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011683 obo:IAO_0000115 "Any ventricular septal defect (VSD) that is small enough to restrict flow across it such that a pressure gradient exists between the two sides of the VSD." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:26:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253551005", "UMLS:C0344924" ; oboInOwl:id "HP:0011683" ; a owl:Class ; rdfs:comment "This term can be used in addition to another term describing the morphology of a VSD." ; rdfs:label "Restrictive ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011684 obo:IAO_0000115 "Any ventricular septal defect (VSD) that does not restrict flow across it sufficiently to generate a pressure gradient between the two sides of the VSD." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:29:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:373131000", "UMLS:C1298817" ; oboInOwl:id "HP:0011684" ; a owl:Class ; rdfs:comment "This term can be used in addition to another term describing the morphology of a VSD." ; rdfs:label "Non-restrictive ventricular septal defect" ; rdfs:subClassOf obo:HP_0001629 . obo:HP_0011685 obo:IAO_0000115 "The superior vena cava passes below the aortic arch." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:36:00Z" ; oboInOwl:hasDbXref "UMLS:C4023232" ; oboInOwl:id "HP:0011685" ; a owl:Class ; rdfs:comment "The superior vena cava normally crosses superior and anterior to the aorta." ; rdfs:label "Infra-aortic superior vena cava" ; rdfs:subClassOf obo:HP_0025575 . obo:HP_0011686 obo:IAO_0000115 "An abnormal path of a coronary artery." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:37:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253714001", "UMLS:C0345122" ; oboInOwl:hasRelatedSynonym "Anomalous coronary artery course" ; oboInOwl:id "HP:0011686" ; a owl:Class ; rdfs:label "Abnormal coronary artery course" ; rdfs:subClassOf obo:HP_0006704 . obo:HP_0011687 obo:IAO_0000115 "A type of supraventricular tachycardia that originates in the atrioventricular node." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T08:45:26Z" ; oboInOwl:hasDbXref "UMLS:C0857265" ; oboInOwl:hasExactSynonym "AV nodal tachycardia", "Atrioventricular nodal tachycardia" ; oboInOwl:id "HP:0011687" ; a owl:Class ; rdfs:label "AV nodal tachycardia" ; rdfs:subClassOf obo:HP_0004755 . obo:HP_0011688 obo:IAO_0000115 "Supraventricular tachycardia in which an accessory pathway connecting the atria and ventricles, apart from the AV node, participates as a necessary part of a reentrant mechanism." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:33:56Z" ; oboInOwl:hasDbXref "UMLS:C4021132" ; oboInOwl:hasExactSynonym "Atrioventricular re-entry tachycardia", "Supraventricular tachycardia with an accessory connexion mediated pathway" ; oboInOwl:id "HP:0011688" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with an accessory connection mediated pathway" ; rdfs:subClassOf obo:HP_0004755 . obo:HP_0011689 obo:IAO_0000115 "Supraventricular tachycardia with an accessory connection mediated pathway that is called concealed becasue it is not seen on the ECG during sinus rhythm." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:35:31Z" ; oboInOwl:hasDbXref "UMLS:C4023231" ; oboInOwl:hasExactSynonym "Supraventricular tachycardia with a concealed accessory connexion" ; oboInOwl:id "HP:0011689" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a concealed accessory connection" ; rdfs:subClassOf obo:HP_0011688 . obo:HP_0011690 obo:IAO_0000115 "An incessant orthodromic tachycardia with anterograde conduction over the atrioventricular node and by retrograde conduction via an accessory pathway usually located in the posteroseptal region with slow and decremental conduction." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:36:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:233904005", "UMLS:C0340483" ; oboInOwl:id "HP:0011690" ; a owl:Class ; rdfs:label "Permanent junctional reciprocating tachycardia" ; rdfs:subClassOf obo:HP_0011689 . obo:HP_0011691 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:36:49Z" ; oboInOwl:hasDbXref "UMLS:C4023230" ; oboInOwl:id "HP:0011691" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a concealed accessory pathway on the left free wall" ; rdfs:subClassOf obo:HP_0011689 . obo:HP_0011692 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:37:37Z" ; oboInOwl:hasDbXref "UMLS:C4023229" ; oboInOwl:id "HP:0011692" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a concealed accessory pathway on the right free wall" ; rdfs:subClassOf obo:HP_0011689 . obo:HP_0011693 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:38:07Z" ; oboInOwl:hasDbXref "UMLS:C4023228" ; oboInOwl:id "HP:0011693" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a concealed accessory pathway on the septum" ; rdfs:subClassOf obo:HP_0011689 . obo:HP_0011694 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:38:53Z" ; oboInOwl:hasDbXref "UMLS:C4023227" ; oboInOwl:id "HP:0011694" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a manifest accessory pathway" ; rdfs:subClassOf obo:HP_0011688 . obo:HP_0011695 obo:IAO_0000115 "Hemorrhage into the parenchyma of the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:46:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:75038005", "UMLS:C0149854" ; oboInOwl:hasExactSynonym "Cerebellar haemorrhage" ; oboInOwl:id "HP:0011695" ; a owl:Class ; rdfs:label "Cerebellar hemorrhage" ; rdfs:subClassOf obo:HP_0002170 . obo:HP_0011696 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:57:34Z" ; oboInOwl:hasDbXref "UMLS:C4023226" ; oboInOwl:id "HP:0011696" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a manifest accessory pathway on the left free wall" ; rdfs:subClassOf obo:HP_0011694 . obo:HP_0011697 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:59:00Z" ; oboInOwl:hasDbXref "UMLS:C4023225" ; oboInOwl:id "HP:0011697" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a manifest accessory pathway on the right free wall" ; rdfs:subClassOf obo:HP_0011694 . obo:HP_0011698 dcterms:creator ; oboInOwl:creation_date "2012-04-10T10:59:45Z" ; oboInOwl:hasDbXref "UMLS:C4023224" ; oboInOwl:id "HP:0011698" ; a owl:Class ; rdfs:label "Supraventricular tachycardia with a manifest accessory pathway on the septum" ; rdfs:subClassOf obo:HP_0011694 . obo:HP_0011699 dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:15:27Z" ; oboInOwl:hasDbXref "UMLS:C4023223" ; oboInOwl:id "HP:0011699" ; a owl:Class ; rdfs:label "Atrial reentry tachycardia" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0011700 obo:IAO_0000115 "Chronic supraventricular tachycardia predominantly seen in childhood." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:19:33Z" ; oboInOwl:hasDbXref "MSH:D013612", "SNOMEDCT_US:233892002", "UMLS:C0039234" ; oboInOwl:id "HP:0011700" ; a owl:Class ; rdfs:label "Automatic atrial tachycardia" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0011701 obo:IAO_0000115 "Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:20:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:49982000", "UMLS:C0221158" ; oboInOwl:hasExactSynonym "Chaotic atrial tachycardia", "Ectopic atrial tachycardia" ; oboInOwl:id "HP:0011701" ; a owl:Class ; rdfs:label "Multifocal atrial tachycardia" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0011702 obo:IAO_0000115 "An abnormality of the sinoatrial (SA) node in the right atrium. THe SA node acts as the pacemaker of the heart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:22:43Z" ; oboInOwl:hasDbXref "Fyler:7010", "UMLS:C4023222" ; oboInOwl:id "HP:0011702" ; a owl:Class ; rdfs:label "Abnormal electrophysiology of sinoatrial node origin" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0011703 obo:IAO_0000115 "Heart rate of greater than 100 beats per minute." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:30:45Z" ; oboInOwl:hasDbXref "MSH:D013616", "SNOMEDCT_US:11092001", "UMLS:C0039239" ; oboInOwl:hasExactSynonym "Sinus tach", "Sinus tachy" ; oboInOwl:id "HP:0011703" ; a owl:Class ; rdfs:label "Sinus tachycardia" ; rdfs:subClassOf obo:HP_0011702 . obo:HP_0011704 obo:IAO_0000115 "An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress." ; dcterms:creator ; oboInOwl:creation_date "2012-04-10T11:31:17Z" ; oboInOwl:hasDbXref "MSH:D012804", "SNOMEDCT_US:36083008", "UMLS:C0037052" ; oboInOwl:hasExactSynonym "Sinoatrial node disease" ; oboInOwl:id "HP:0011704" ; a owl:Class ; rdfs:label "Sick sinus syndrome" ; rdfs:subClassOf obo:HP_0011702, obo:HP_0012722 . obo:HP_0011705 obo:IAO_0000115 "Delay of conduction through the atrioventricular node, which is manifested as prolongation of the PR interval in the electrocardiogram (EKG). All atrial impulses reach the ventricles." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:17:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:270492004", "UMLS:C0085614" ; oboInOwl:id "HP:0011705" ; a owl:Class ; rdfs:comment "The conduction of the cardiac impulse through the atrioventricular node is manifested in the EKG by the PR interval, which is normally less that 200 milliseconds in adults. Normal values are age-dependent in children, but normal values are less that 160 milliseconds in young children." ; rdfs:label "First degree atrioventricular block" ; rdfs:subClassOf obo:HP_0001678 . obo:HP_0011706 obo:IAO_0000115 "An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:22:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:195042002", "UMLS:C0264906" ; oboInOwl:id "HP:0011706" ; a owl:Class ; rdfs:label "Second degree atrioventricular block" ; rdfs:subClassOf obo:HP_0001678 . obo:HP_0011707 obo:IAO_0000115 "Progressive PR interval prolongation with the subsequent occurrence of a single nonconducted P wave that results in a pause. The pause that follows the nonconducted impulse is less than fully compensatory (less than the sum of two normal sinus intervals)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:25:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:54016002", "UMLS:C0264907" ; oboInOwl:hasExactSynonym "Mobitz type 1 atrioventricular block", "Wenckebach block" ; oboInOwl:id "HP:0011707" ; a owl:Class ; rdfs:comment "Mobitz I atrioventricular block is associated with a normal QRS duration." ; rdfs:label "Mobitz I atrioventricular block" ; rdfs:subClassOf obo:HP_0011706 . obo:HP_0011708 obo:IAO_0000115 "A type of second degree atrioventricular (AV) block characterized by sudden failure to conduct an impulse through the AV node without a preceding change in the PR interval." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:34:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:28189009", "UMLS:C0155700" ; oboInOwl:hasExactSynonym "Mobitz type 2 atrioventricular block" ; oboInOwl:id "HP:0011708" ; a owl:Class ; rdfs:comment "Mobitz I atrioventricular block is usually associated with a prolonged QRS duration." ; rdfs:label "Mobitz II atrioventricular block" ; rdfs:subClassOf obo:HP_0011706 . obo:HP_0011709 obo:IAO_0000115 "Atrioventricular (AV) dissociation is present if the atria and the ventricles are under the control of two separate pacemakers. AV dissociation can occur in the absence of a primary AV conduction disturbance." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:46:37Z" ; oboInOwl:hasDbXref "MSH:D006327", "SNOMEDCT_US:50799005", "UMLS:C0004331" ; oboInOwl:id "HP:0011709" ; a owl:Class ; rdfs:comment "Atrioventricular dissociation can develop in response to severe sinus bradycardia with AV junctional rhythm or with an enhanced lower (junctional or ventricular) pacemaker that competes with the normal sinus rhythm and exceeds it." ; rdfs:label "Atrioventricular dissociation" ; rdfs:subClassOf obo:HP_0005150 . obo:HP_0011710 obo:IAO_0000115 "Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T07:55:50Z" ; oboInOwl:hasDbXref "MSH:D002037", "SNOMEDCT_US:6374002", "UMLS:C0006384" ; oboInOwl:hasExactSynonym "Bundle-branch block" ; oboInOwl:id "HP:0011710" ; a owl:Class ; rdfs:comment "The Bundle of His conducts the electrical impulse from the atrioventricular node into the ventricles. THe Bundle of His divides into right and left bundle branches. A universal feature of a bundle branch block is a prolongation of the time required for depolarization of a portion of the ventricles, reflected in an abnormality of the QRS complex." ; rdfs:label "Bundle branch block" ; rdfs:subClassOf obo:HP_0012722 . obo:HP_0011711 obo:IAO_0000115 "Conduction block in the anterior division of the left bundle branch of the bundle of His." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:02:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:37760005", "UMLS:C0264912" ; oboInOwl:hasExactSynonym "Left anterior hemiblock" ; oboInOwl:id "HP:0011711" ; a owl:Class ; rdfs:label "Left anterior fascicular block" ; rdfs:subClassOf obo:HP_0011713 . obo:HP_0011712 obo:IAO_0000115 "A conduction block of the right branch of the bundle of His. This manifests as a prolongation of the QRS complex (greater than 0.12 s) with delayed activation of the right ventricle and terminal delay on the EKG." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:02:08Z" ; oboInOwl:hasDbXref "MSH:D002037", "SNOMEDCT_US:59118001", "UMLS:C0085615" ; oboInOwl:hasExactSynonym "Right bundle-branch block" ; oboInOwl:id "HP:0011712" ; a owl:Class ; rdfs:label "Right bundle branch block" ; rdfs:subClassOf obo:HP_0011710 . obo:HP_0011713 obo:IAO_0000115 "A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:04:34Z" ; oboInOwl:hasDbXref "MSH:D002037", "SNOMEDCT_US:63467002", "UMLS:C0023211" ; oboInOwl:id "HP:0011713" ; a owl:Class ; rdfs:label "Left bundle branch block" ; rdfs:subClassOf obo:HP_0011710 . obo:HP_0011714 obo:IAO_0000115 "Libman-Sacks valvular lesions are sterile fibrofibrinous vegetations that favor the left-sided heart valves and usually form on the ventricular surface of the mitral valve." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T10:11:39Z" ; oboInOwl:hasDbXref "UMLS:C4023221" ; oboInOwl:id "HP:0011714" ; a owl:Class ; rdfs:comment "Libman-Sacks lesions are y typical manifestation of systemic lupus erythematosus." ; rdfs:label "Libman-Sacks lesions" ; rdfs:subClassOf obo:HP_0100584 . obo:HP_0011715 obo:IAO_0000115 "Abnormal conduction in all three divisions of the intraventricular conducting tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:10:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:86014007", "UMLS:C0155707" ; oboInOwl:id "HP:0011715" ; a owl:Class ; rdfs:label "Trifascicular block" ; rdfs:subClassOf obo:HP_0011710 . obo:HP_0011716 obo:IAO_0000115 "Junctional ectopic tachycardia (JET) is a unique type of supraventricular arrhythmia defined by narrow QRS complex and atrioventricular (AV) dissociation or retrograde atrial conduction in a 1:1 pattern." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:42:28Z" ; oboInOwl:hasDbXref "MSH:D013613", "SNOMEDCT_US:233901002", "SNOMEDCT_US:419166005", "UMLS:C0039235" ; oboInOwl:id "HP:0011716" ; a owl:Class ; rdfs:label "Junctional ectopic tachycardia" ; rdfs:subClassOf obo:HP_0011687 . obo:HP_0011717 obo:IAO_0000115 "Accessory pathway-related atrioventricular reentrant tachycardia (AVRT) involves an abnormal electrical conduction of the accessory pathway. The accessory pathway connecting impulses between the atrium and the ventricle can be seen at any site in the AV groove." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:42:52Z" ; oboInOwl:hasDbXref "UMLS:C4023220" ; oboInOwl:hasExactSynonym "AV nodal reentry tachycardia" ; oboInOwl:id "HP:0011717" ; a owl:Class ; rdfs:label "Atrioventricular reentrant tachycardia" ; rdfs:subClassOf obo:HP_0011687 . obo:HP_0011718 obo:IAO_0000115 "An abnormality of the pulmonary veins." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:45:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:111322000", "SNOMEDCT_US:128585006", "SNOMEDCT_US:199113001", "UMLS:C0265914" ; oboInOwl:hasExactSynonym "Abnormality of lung veins" ; oboInOwl:id "HP:0011718" ; a owl:Class ; rdfs:comment "The right superior, right inferior, left superior, and left inferior pulmonary veins carry oxygenated blood to the left atrium." ; rdfs:label "Abnormality of the pulmonary veins" ; rdfs:subClassOf obo:HP_0004930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011719 obo:IAO_0000115 "Type 1 total anomalous pulmonary venous connection." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:50:39Z" ; oboInOwl:hasDbXref "Fyler:0910", "Fyler:910", "UMLS:C4021131" ; oboInOwl:hasExactSynonym "Supracardiac total anomalous pulmonary venous connexion", "Total anomalous pulmonary venous connection, supracardiac", "Type 1 total anomalous pulmonary venous connection" ; oboInOwl:id "HP:0011719" ; a owl:Class ; rdfs:label "Supracardiac total anomalous pulmonary venous connection" ; rdfs:subClassOf obo:HP_0005160 . obo:HP_0011720 obo:IAO_0000115 "Type 2 total anomalous pulmonary venous connection." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:51:32Z" ; oboInOwl:hasDbXref "Fyler:0920", "Fyler:0930", "Fyler:920", "Fyler:930", "UMLS:C4021130" ; oboInOwl:hasExactSynonym "Cardiac total anomalous pulmonary venous connexion", "Total anomalous pulmonary venous connection, intracardiac", "Type 2 total anomalous pulmonary venous connection" ; oboInOwl:id "HP:0011720" ; a owl:Class ; rdfs:label "Cardiac total anomalous pulmonary venous connection" ; rdfs:subClassOf obo:HP_0005160 . obo:HP_0011721 obo:IAO_0000115 "Type 3 total anomalous pulmonary venous connection." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:52:28Z" ; oboInOwl:hasDbXref "UMLS:C4021129" ; oboInOwl:hasExactSynonym "Infracardiac total anomalous pulmonary venous connexion", "Type 3 total anomalous pulmonary venous connection" ; oboInOwl:id "HP:0011721" ; a owl:Class ; rdfs:label "Infracardiac total anomalous pulmonary venous connection" ; rdfs:subClassOf obo:HP_0005160 . obo:HP_0011722 obo:IAO_0000115 "Type 4 total anomalous pulmonary venous connection." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:53:37Z" ; oboInOwl:hasDbXref "Fyler:0950", "Fyler:950", "UMLS:C4021128" ; oboInOwl:hasExactSynonym "Mixed total anomalous pulmonary venous connexion", "Total anomalous pulmonary venous connection, mixed", "Type 4 total anomalous pulmonary venous connection" ; oboInOwl:id "HP:0011722" ; a owl:Class ; rdfs:label "Mixed total anomalous pulmonary venous connection" ; rdfs:subClassOf obo:HP_0005160 . obo:HP_0011723 obo:IAO_0000115 "Defect or defects of the morphogenesis of the right heart identifiable at birth." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:56:19Z" ; oboInOwl:hasDbXref "UMLS:C4023219" ; oboInOwl:id "HP:0011723" ; a owl:Class ; rdfs:label "Congenital malformation of the right heart" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_0011724 obo:IAO_0000115 "Uhl anomaly of the right ventricle refers to the almost complete absence of right ventricular myocardium, normal tricuspid valve, and preserved septal and left ventricular myocardium." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T08:59:07Z" ; oboInOwl:hasDbXref "MSH:C536932", "SNOMEDCT_US:2829000", "UMLS:C0265857" ; oboInOwl:id "HP:0011724" ; a owl:Class ; rdfs:label "Uhl's anomaly" ; rdfs:subClassOf obo:HP_0011723 . obo:HP_0011725 dcterms:creator ; oboInOwl:creation_date "2012-04-11T09:01:14Z" ; oboInOwl:hasDbXref "UMLS:C4023218" ; oboInOwl:id "HP:0011725" ; a owl:Class ; rdfs:label "Chaotic multifocal atrial tachycardia" ; rdfs:subClassOf obo:HP_0001692 . obo:HP_0011726 obo:IAO_0000115 "Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T09:02:26Z" ; oboInOwl:hasDbXref "MSH:D010547", "SNOMEDCT_US:206597007", "SNOMEDCT_US:233815004", "SNOMEDCT_US:35604006", "UMLS:C0031190" ; oboInOwl:hasExactSynonym "Persistent foetal circulation" ; oboInOwl:id "HP:0011726" ; a owl:Class ; rdfs:label "Persistent fetal circulation" ; rdfs:subClassOf obo:HP_0034190 . obo:HP_0011727 obo:IAO_0000115 "Weakness of the peroneal muscles." ; dcterms:creator ; oboInOwl:creation_date "2012-04-11T10:26:15Z" ; oboInOwl:hasDbXref "UMLS:C0240733" ; oboInOwl:hasExactSynonym "Fibularis muscle weakness" ; oboInOwl:id "HP:0011727" ; a owl:Class ; rdfs:comment "THe peroneal muscles (also known as fibularis muscles) originate from the fibula. The peroneal longus and brevis muscles are located on the lateral side of the leg, while peroneal tertius is on the anterior side." ; rdfs:label "Peroneal muscle weakness" ; rdfs:subClassOf obo:HP_0009053 . obo:HP_0011728 obo:IAO_0000115 "Clonus at the elbow joint, i.e., an exaggerated phasic stretch reflex characterized by repetitive, rhythmic contractions at the elbow, generated by rapid passive stretch at the elbow joint." ; dcterms:creator ; oboInOwl:creation_date "2012-04-17T08:56:48Z" ; oboInOwl:hasDbXref "UMLS:C4023217" ; oboInOwl:id "HP:0011728" ; a owl:Class ; rdfs:label "Elbow clonus" ; rdfs:subClassOf obo:HP_0002169 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002169 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011729 obo:IAO_0000115 "An abnormality in the range and ease of motion of joints across their normal range." ; dcterms:creator ; oboInOwl:creation_date "2012-04-18T07:09:28Z" ; oboInOwl:hasDbXref "UMLS:C4023216" ; oboInOwl:id "HP:0011729" ; a owl:Class ; rdfs:label "Abnormality of joint mobility" ; rdfs:subClassOf obo:HP_0034430 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000004 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011730 obo:IAO_0000115 "An abnormality of sensation related to CNS function. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function may indicate a lesion of a parietal cortex, the thalamocortical projections to the parietal cortex, or the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2012-04-19T07:44:18Z" ; oboInOwl:hasDbXref "UMLS:C4023215" ; oboInOwl:hasExactSynonym "Abnormality of central sensory function" ; oboInOwl:id "HP:0011730" ; a owl:Class ; rdfs:label "Abnormal central sensory function" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0011731 obo:IAO_0000115 "An abnormality of the concentration of cortisol in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T07:59:26Z" ; oboInOwl:hasDbXref "UMLS:C4023214" ; oboInOwl:id "HP:0011731" ; a owl:Class ; rdfs:label "Abnormality of circulating cortisol level" ; rdfs:subClassOf obo:HP_0012111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17650 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011732 obo:IAO_0000115 "Any structural anomaly of the adrenal glands." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T08:04:29Z" ; oboInOwl:hasDbXref "UMLS:C4023213" ; oboInOwl:id "HP:0011732" ; a owl:Class ; rdfs:label "Abnormality of adrenal morphology" ; rdfs:subClassOf obo:HP_0000834, obo:HP_0031071 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011733 obo:IAO_0000115 "A functional abnormality of the adrenal glands." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T08:05:42Z" ; oboInOwl:hasAlternativeId "HP:0002855" ; oboInOwl:hasDbXref "UMLS:C4023212" ; oboInOwl:id "HP:0011733" ; a owl:Class ; rdfs:label "Abnormality of adrenal physiology" ; rdfs:subClassOf obo:HP_0000834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011734 obo:IAO_0000115 "A form of adrenal insufficiency related to a lack of ACTH, which leads to a decrease in the production of cortisol by the adrenal glands. Aldosterone production is not usually affected." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T08:26:19Z" ; oboInOwl:hasDbXref "UMLS:C0948387" ; oboInOwl:hasExactSynonym "Secondary adrenal insufficiency" ; oboInOwl:id "HP:0011734" ; a owl:Class ; rdfs:label "Central adrenal insufficiency" ; rdfs:subClassOf obo:HP_0000846 . obo:HP_0011735 obo:IAO_0000115 "Adrenal insufficiency secondary to a defect in ACTH production." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:06:46Z" ; oboInOwl:hasDbXref "UMLS:C4023211" ; oboInOwl:hasExactSynonym "ACTH deficient adrenal insufficiency" ; oboInOwl:id "HP:0011735" ; a owl:Class ; rdfs:label "Adrenocorticotropin deficient adrenal insufficiency" ; rdfs:subClassOf obo:HP_0011734 . obo:HP_0011736 obo:IAO_0000115 "A form of hyperaldosteronism caused by a defect within the adrenal gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:26:05Z" ; oboInOwl:hasDbXref "MSH:D006929", "SNOMEDCT_US:190507007", "SNOMEDCT_US:258117004", "UMLS:C1384514" ; oboInOwl:id "HP:0011736" ; a owl:Class ; rdfs:label "Primary hyperaldosteronism" ; rdfs:subClassOf obo:HP_0000859 . obo:HP_0011737 obo:IAO_0000115 "Adrenal insufficiency secondary to a defect in corticotropin-releasing hormone production." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:09:56Z" ; oboInOwl:hasDbXref "UMLS:C4021127" ; oboInOwl:hasExactSynonym "CRH deficient adrenal insufficiency", "Tertiary adrenal insufficiency" ; oboInOwl:id "HP:0011737" ; a owl:Class ; rdfs:label "Corticotropin-releasing hormone deficient adrenal insufficiency" ; rdfs:subClassOf obo:HP_0011734 . obo:HP_0011738 obo:IAO_0000115 "Adrenal insufficiency secondary to a defect in the corticotropin-releasing hormone receptor." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:11:04Z" ; oboInOwl:hasDbXref "UMLS:C4020745", "UMLS:C4023210" ; oboInOwl:hasExactSynonym "CRHR defect" ; oboInOwl:hasRelatedSynonym "Corticotropin-releasing hormone receptor (CRHR) resistance" ; oboInOwl:id "HP:0011738" ; a owl:Class ; rdfs:label "Corticotropin-releasing hormone receptor defect" ; rdfs:subClassOf obo:HP_0011734 . obo:HP_0011739 obo:IAO_0000115 "A form of primary hyperaldosteronism in which the overproduction of aldosterone can be suppressed by the administration of dexamethasone." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:27:36Z" ; oboInOwl:hasDbXref "UMLS:C4020743", "UMLS:C4020744", "UMLS:C4023209" ; oboInOwl:hasRelatedSynonym "Familial primary hyperaldosteronism type 1", "Glucocorticoid-remediable familial primary aldosteronism" ; oboInOwl:id "HP:0011739" ; a owl:Class ; rdfs:label "Dexamethasone-suppressible primary hyperaldosteronism" ; rdfs:subClassOf obo:HP_0011736 . obo:HP_0011740 obo:IAO_0000115 "A form of primary hyperaldosteronism in which the overproduction of aldosterone cannot be suppressed by the administration of dexamethasone or similar glucocorticoids." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:29:51Z" ; oboInOwl:hasDbXref "UMLS:C4020742", "UMLS:C4023208" ; oboInOwl:hasRelatedSynonym "Familial primary hyperaldosteronism type 2" ; oboInOwl:id "HP:0011740" ; a owl:Class ; rdfs:label "Glucocortocoid-insensitive primary hyperaldosteronism" ; rdfs:subClassOf obo:HP_0011736 . obo:HP_0011741 obo:IAO_0000115 "A form of hyperaldosteronism caused by abnormally increased renin levels." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:32:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:67805000", "UMLS:C0271728" ; oboInOwl:hasExactSynonym "Hyperreninemic hyperaldosteronism" ; oboInOwl:id "HP:0011741" ; a owl:Class ; rdfs:label "Secondary hyperaldosteronism" ; rdfs:subClassOf obo:HP_0000859 . obo:HP_0011742 obo:IAO_0000115 "Abnormal anatomical location of the adrenal gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:45:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:49494003", "UMLS:C0266275" ; oboInOwl:hasExactSynonym "Abnormal adrenal gland position" ; oboInOwl:id "HP:0011742" ; a owl:Class ; rdfs:label "Ectopic adrenal gland" ; rdfs:subClassOf obo:HP_0011732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011743 obo:IAO_0000115 "Absent development of the adrenal gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T09:46:49Z" ; oboInOwl:hasDbXref "MSH:C538429", "SNOMEDCT_US:702615004", "SNOMEDCT_US:83190008", "UMLS:C0266273" ; oboInOwl:id "HP:0011743" ; a owl:Class ; rdfs:label "Adrenal gland agenesis" ; rdfs:subClassOf obo:HP_0008216 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002369 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011744 obo:IAO_0000115 "Hypercortisolemia associated with a overproduction of ACTH (often from a tumor), leading secondarily to overproduction of cortisol." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T11:46:27Z" ; oboInOwl:hasDbXref "UMLS:C4020741", "UMLS:C4023207" ; oboInOwl:hasRelatedSynonym "ACTH-dependent hypercortisolemia" ; oboInOwl:id "HP:0011744" ; a owl:Class ; rdfs:label "Secondary hypercortisolism" ; rdfs:subClassOf obo:HP_0003118 . obo:HP_0011745 obo:IAO_0000115 "An hormonally inactive adrenocortical adenoma, that is, an adenoma that does not secrete excessive amounts of adrenal hormones." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T11:55:18Z" ; oboInOwl:hasDbXref "UMLS:C4021126" ; oboInOwl:hasExactSynonym "Non-secretory adrenal adenoma" ; oboInOwl:id "HP:0011745" ; a owl:Class ; rdfs:label "Non-secretory adrenocortical adenoma" ; rdfs:subClassOf obo:HP_0008256 . obo:HP_0011746 obo:IAO_0000115 "An hormonally active adrenocortical adenoma, that is, an adenoma that secretes excessive amounts of adrenal hormones." ; dcterms:creator ; oboInOwl:creation_date "2012-04-21T11:58:38Z" ; oboInOwl:hasDbXref "UMLS:C4021125" ; oboInOwl:hasExactSynonym "Secretory adrenal adenoma" ; oboInOwl:id "HP:0011746" ; a owl:Class ; rdfs:label "Secretory adrenocortical adenoma" ; rdfs:subClassOf obo:HP_0008256 . obo:HP_0011747 obo:IAO_0000115 "An abnormality of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T11:17:00Z" ; oboInOwl:hasDbXref "MSH:D010900", "SNOMEDCT_US:399244003", "UMLS:C0032002", "UMLS:C4023206" ; oboInOwl:hasRelatedSynonym "Pituitary disease" ; oboInOwl:id "HP:0011747" ; a owl:Class ; rdfs:label "Abnormality of the anterior pituitary" ; rdfs:subClassOf obo:HP_0012503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011748 obo:IAO_0000115 "A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T11:27:04Z" ; oboInOwl:hasDbXref "MSH:C535668", "SNOMEDCT_US:237692001", "UMLS:C0342388" ; oboInOwl:hasExactSynonym "ACTH deficiency", "Corticotropin deficiency" ; oboInOwl:id "HP:0011748" ; a owl:Class ; rdfs:label "Adrenocorticotropic hormone deficiency" ; rdfs:subClassOf obo:HP_0000830 . obo:HP_0011749 obo:IAO_0000115 "Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:09:54Z" ; oboInOwl:hasDbXref "UMLS:C4021124" ; oboInOwl:hasExactSynonym "ACTH excess" ; oboInOwl:id "HP:0011749" ; a owl:Class ; rdfs:comment "This term refers to increased production of ACTH. If additionally hypercorticolism is present, this should be coded separated with HP:0011744." ; rdfs:label "Adrenocorticotropic hormone excess" ; rdfs:subClassOf obo:HP_0010514 . obo:HP_0011750 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:18:46Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4023205" ; oboInOwl:hasExactSynonym "Neoplasm of the adenohypophysis", "Neoplasm of the pars anterior" ; oboInOwl:id "HP:0011750" ; a owl:Class ; rdfs:label "Neoplasm of the anterior pituitary" ; rdfs:subClassOf obo:HP_0011747, obo:HP_0040277 . obo:HP_0011751 obo:IAO_0000115 "An abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:20:33Z" ; oboInOwl:hasDbXref "UMLS:C4023204" ; oboInOwl:hasExactSynonym "Abnormality of the neurohypophysis", "Abnormality of the posterior pituitary" ; oboInOwl:id "HP:0011751" ; a owl:Class ; rdfs:label "Abnormal posterior pituitary morphogenesis" ; rdfs:subClassOf obo:HP_0012503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011752 obo:IAO_0000115 "The presence of a neoplasm (tumor) in the neurohypophysis, which is also known as the posterior lobe of the hypophysis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:31:18Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C1334957" ; oboInOwl:hasExactSynonym "Neoplasm of the neurohypophysis" ; oboInOwl:id "HP:0011752" ; a owl:Class ; rdfs:label "Neoplasm of the posterior pituitary" ; rdfs:subClassOf obo:HP_0011751 . obo:HP_0011753 obo:IAO_0000115 "Abnormal development of the neurohypophysis during embryonic growth and development." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:42:04Z" ; oboInOwl:hasDbXref "UMLS:C4021123" ; oboInOwl:hasExactSynonym "Neurohypophysis dysplasia", "Posterior pituitary dysplasia" ; oboInOwl:id "HP:0011753" ; a owl:Class ; rdfs:label "Posterior pituitary dysgenesis" ; rdfs:subClassOf obo:HP_0011751 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011754 obo:IAO_0000115 "A solid, low grade, spindle cell, glial neoplasm of adults that originates in the neurohypophysis or infundibulum. Clinical signs and symptoms include visual disturbance, headache and features of hypopituitarism. Pituicytomas are well-circumscribed, solid masses that can measure up to several centimeters. Histologically, they show a compact architecture consisting of elongate, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:34:00Z" ; oboInOwl:hasDbXref "ICD-O:9432/1", "SNOMEDCT_US:450901008", "SNOMEDCT_US:608817003", "UMLS:C2986550" ; oboInOwl:id "HP:0011754" ; a owl:Class ; rdfs:label "Pituicytoma" ; rdfs:subClassOf obo:HP_0011752 . obo:HP_0011755 obo:IAO_0000115 "An abnormal anatomical location of the posterior lobe of the hypophysis, also known as the neurohypophysis. The posterior pituitary is normally present in the dorsal portion of the sella turcica, but when ectopic is usually near the median eminence. This defect is likely to be due to abnormal migration during embryogenesis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:43:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:715727009", "UMLS:C3279571", "UMLS:C4053775" ; oboInOwl:hasExactSynonym "Ectopic neurohypophysis", "Ectopic posterior pituitary lobe" ; oboInOwl:id "HP:0011755" ; a owl:Class ; rdfs:label "Ectopic posterior pituitary" ; rdfs:subClassOf obo:HP_0011753 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011756 obo:IAO_0000115 "Absence of the neurohypophysis owing to a developmental defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:55:35Z" ; oboInOwl:hasDbXref "UMLS:C4023203" ; oboInOwl:hasExactSynonym "Neurohypophysis agenesis" ; oboInOwl:id "HP:0011756" ; a owl:Class ; rdfs:label "Posterior pituitary agenesis" ; rdfs:subClassOf obo:HP_0011753 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011757 obo:IAO_0000115 "Underdevelopment of the neurohypophysis." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T01:56:23Z" ; oboInOwl:hasDbXref "UMLS:C4023202" ; oboInOwl:hasExactSynonym "Neurohypophysis hypoplasia" ; oboInOwl:id "HP:0011757" ; a owl:Class ; rdfs:label "Posterior pituitary hypoplasia" ; rdfs:subClassOf obo:HP_0011753 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011758 dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:03:47Z" ; oboInOwl:hasDbXref "UMLS:C4023201" ; oboInOwl:id "HP:0011758" ; a owl:Class ; rdfs:label "Pituitary acidophilic stem cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0011759 obo:IAO_0000115 "A type of pituitary adenoma that produces gonadotropins." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:37:35Z" ; oboInOwl:hasDbXref "UMLS:C4021122" ; oboInOwl:hasExactSynonym "Pituitary gonadotropinoma" ; oboInOwl:id "HP:0011759" ; a owl:Class ; rdfs:label "Pituitary gonadotropic cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0011760 obo:IAO_0000115 "A type of pituitary adenoma that produces growth hormone." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:38:10Z" ; oboInOwl:hasDbXref "UMLS:C4018860" ; oboInOwl:hasExactSynonym "Pituitary somatotropinoma" ; oboInOwl:id "HP:0011760" ; a owl:Class ; rdfs:label "Pituitary growth hormone cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0011761 obo:IAO_0000115 "A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:39:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:254962005", "UMLS:C0338078" ; oboInOwl:hasExactSynonym "Clinically silent pituitary adenoma", "Hormonally silent pituitary adenoma", "Non-functional pituitary adenoma", "Silent pituitary adenoma" ; oboInOwl:id "HP:0011761" ; a owl:Class ; rdfs:label "Pituitary null cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0011762 obo:IAO_0000115 "A type of pituitary adenoma that produces thyroid stimulating hormone (TSH)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:42:08Z" ; oboInOwl:hasDbXref "UMLS:C4021121" ; oboInOwl:hasExactSynonym "Pituitary thyrotropinoma" ; oboInOwl:id "HP:0011762" ; a owl:Class ; rdfs:label "Pituitary thyrotropic cell adenoma" ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0011763 obo:IAO_0000115 "A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:52:30Z" ; oboInOwl:hasDbXref "MSH:D010911", "SNOMEDCT_US:128665000", "SNOMEDCT_US:254955001", "UMLS:C0346300" ; oboInOwl:id "HP:0011763" ; a owl:Class ; rdfs:label "Pituitary carcinoma" ; rdfs:subClassOf obo:HP_0011750 . obo:HP_0011764 obo:IAO_0000115 "A spindled-to-epithelioid, oncocytic, nonendocrine neoplasm of the anterior hypophysis that manifests in adults and follows a benign clinical course. Pituitary spindle cell oncocytomas are firm, fibrous, and adherent to surrounding structures and are highly vascular." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T03:57:01Z" ; oboInOwl:hasDbXref "UMLS:C4023200" ; oboInOwl:id "HP:0011764" ; a owl:Class ; rdfs:label "Pituitary spindle cell oncocytoma" ; rdfs:subClassOf obo:HP_0011750 . obo:HP_0011765 obo:IAO_0100001 "HP:0012731" ; oboInOwl:id "HP:0011765" ; a owl:Class ; rdfs:label "obsolete Ectopic anterior pituitary" ; owl:deprecated true . obo:HP_0011766 obo:IAO_0000115 "A structural abnormality of the parathyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:08:26Z" ; oboInOwl:hasDbXref "UMLS:C4023199" ; oboInOwl:id "HP:0011766" ; a owl:Class ; rdfs:label "Abnormality of the parathyroid morphology" ; rdfs:subClassOf obo:HP_0000828 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011767 obo:IAO_0000115 "A functional abnormality of the parathyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:09:13Z" ; oboInOwl:hasBroadSynonym "Parathyroid issue" ; oboInOwl:hasDbXref "UMLS:C4023198" ; oboInOwl:hasExactSynonym "Parathyroid dysfunction" ; oboInOwl:id "HP:0011767" ; a owl:Class ; rdfs:label "Abnormality of the parathyroid physiology" ; rdfs:subClassOf obo:HP_0000828 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011768 obo:IAO_0000115 "Abnormal embryonic development of the parathyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:20:41Z" ; oboInOwl:hasDbXref "UMLS:C4023197" ; oboInOwl:id "HP:0011768" ; a owl:Class ; rdfs:label "Parathyroid dysgenesis" ; rdfs:subClassOf obo:HP_0011766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011769 obo:IAO_0000115 "An abnormal anatomical location of the parathyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023196" ; oboInOwl:id "HP:0011769" ; a owl:Class ; rdfs:label "Ectopic parathyroid" ; rdfs:subClassOf obo:HP_0011768 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011770 obo:IAO_0000115 "A type of hyperparathyroidism that occurs following kidney transplantation, which is a treatment for secondary hyperparathyroidism. Although kidney transplantation leads to a normalization of serum calcium and parathyroid hormone in most patients. The state of persistent hypercalcemia and hyperparathyroidism is referred to as tertiary hyperparathyroidism." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:38:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:78200003", "UMLS:C0271858" ; oboInOwl:id "HP:0011770" ; a owl:Class ; rdfs:label "Tertiary hyperparathyroidism" ; rdfs:subClassOf obo:HP_0000843 . obo:HP_0011771 obo:IAO_0000115 "A type of hypoparathyroidism with circulating antiparathyroid or anti-calcium sensing receptor antibodies indicative of autoimmunity." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T04:54:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:75316000", "UMLS:C0271865" ; oboInOwl:id "HP:0011771" ; a owl:Class ; rdfs:label "Autoimmune hypoparathyroidism" ; rdfs:subClassOf obo:HP_0000829 . obo:HP_0011772 obo:IAO_0000115 "A structural abnormality of the thyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T05:54:57Z" ; oboInOwl:hasDbXref "UMLS:C4023195" ; oboInOwl:hasExactSynonym "Abnormal shape of thyroid gland", "Abnormality of thyroid morphology" ; oboInOwl:id "HP:0011772" ; a owl:Class ; rdfs:label "Abnormal thyroid morphology" ; rdfs:subClassOf obo:HP_0000820 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011773 obo:IAO_0000115 "Enlargement of the thyroid gland related to a singular nodule in the thyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T05:56:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237569006", "UMLS:C0342205" ; oboInOwl:hasExactSynonym "Uninodular goitre" ; oboInOwl:id "HP:0011773" ; a owl:Class ; rdfs:label "Uninodular goiter" ; rdfs:subClassOf obo:HP_0005994 . obo:HP_0011774 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:01:31Z" ; oboInOwl:hasDbXref "MSH:D013964", "SNOMEDCT_US:255033000", "SNOMEDCT_US:255034006", "UMLS:C0151468" ; oboInOwl:id "HP:0011774" ; a owl:Class ; rdfs:label "Thyroid follicular adenoma" ; rdfs:subClassOf obo:HP_0000854 . obo:HP_0011775 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:01:42Z" ; oboInOwl:hasDbXref "UMLS:C4023194" ; oboInOwl:id "HP:0011775" ; a owl:Class ; rdfs:label "Thyroid macrofollicular adenoma" ; rdfs:subClassOf obo:HP_0011774 . obo:HP_0011776 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:01:48Z" ; oboInOwl:hasDbXref "UMLS:C4023193" ; oboInOwl:id "HP:0011776" ; a owl:Class ; rdfs:label "Thyroid microfollicular adenoma" ; rdfs:subClassOf obo:HP_0011774 . obo:HP_0011777 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:02:12Z" ; oboInOwl:hasDbXref "UMLS:C4023192" ; oboInOwl:id "HP:0011777" ; a owl:Class ; rdfs:label "Thyroid papillary adenoma" ; rdfs:subClassOf obo:HP_0000854 . obo:HP_0011778 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:02:26Z" ; oboInOwl:hasDbXref "UMLS:C4023191" ; oboInOwl:id "HP:0011778" ; a owl:Class ; rdfs:label "Thyroid atypical adenoma" ; rdfs:subClassOf obo:HP_0000854 . obo:HP_0011779 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:02:52Z" ; oboInOwl:hasDbXref "MSH:D065646", "SNOMEDCT_US:255031003", "UMLS:C0238461" ; oboInOwl:id "HP:0011779" ; a owl:Class ; rdfs:label "Anaplastic thyroid carcinoma" ; rdfs:subClassOf obo:HP_0002890 . obo:HP_0011780 obo:IAO_0000115 "Absence of a lobe of the thyroid gland related to a failure of its embryologic development." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:04:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:715734006", "UMLS:C4023190" ; oboInOwl:id "HP:0011780" ; a owl:Class ; rdfs:label "Thyroid hemiagenesis" ; rdfs:subClassOf obo:HP_0033079 . obo:HP_0011781 obo:IAO_0000115 "An abnormal growth of parafollicular (C-cells) cells." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:05:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237552009", "UMLS:C0342190" ; oboInOwl:id "HP:0011781" ; a owl:Class ; rdfs:comment "Thyroid C cell hyperplasia usually occurs before the development of familial forms of medullary thyroid cancer and is considered a pre-cancerous condition." ; rdfs:label "Thyroid C cell hyperplasia" ; rdfs:subClassOf obo:HP_0008249 . obo:HP_0011782 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:10:37Z" ; oboInOwl:hasDbXref "MSH:D013958", "SNOMEDCT_US:29028009", "UMLS:C0040127" ; oboInOwl:id "HP:0011782" ; a owl:Class ; rdfs:label "Thyroid crisis" ; rdfs:subClassOf obo:HP_0000836 . obo:HP_0011783 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:10:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:87232008", "UMLS:C0154148" ; oboInOwl:id "HP:0011783" ; a owl:Class ; rdfs:label "Thyrotoxicosis from ectopic thyroid tissue" ; rdfs:subClassOf obo:HP_0000836 . obo:HP_0011784 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:11:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:267374005", "UMLS:C0342122" ; oboInOwl:hasExactSynonym "Thyrotoxicosis with diffuse goitre" ; oboInOwl:id "HP:0011784" ; a owl:Class ; rdfs:label "Thyrotoxicosis with diffuse goiter" ; rdfs:subClassOf obo:HP_0000836 . obo:HP_0011785 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:15:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:26389007", "UMLS:C0154143" ; oboInOwl:hasExactSynonym "Thyrotoxicosis with toxic multinodular goitre" ; oboInOwl:id "HP:0011785" ; a owl:Class ; rdfs:label "Thyrotoxicosis with toxic multinodular goiter" ; rdfs:subClassOf obo:HP_0000836 . obo:HP_0011786 dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:16:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:69329005", "SNOMEDCT_US:73869005", "UMLS:C0154141" ; oboInOwl:id "HP:0011786" ; a owl:Class ; rdfs:label "Thyrotoxicosis with toxic single thyroid nodule" ; rdfs:subClassOf obo:HP_0000836 . obo:HP_0011787 obo:IAO_0000115 "A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:25:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:26692000", "UMLS:C0271801" ; oboInOwl:id "HP:0011787" ; a owl:Class ; rdfs:label "Central hypothyroidism" ; rdfs:subClassOf obo:HP_0000821 . obo:HP_0011788 obo:IAO_0000115 "An elevated concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:31:08Z" ; oboInOwl:hasDbXref "UMLS:C4021843" ; oboInOwl:hasExactSynonym "Increased circulating free triiodothyronine", "Increased serum fT3", "Increased serum free T3", "Increased serum free triiodothyronine" ; oboInOwl:id "HP:0011788" ; a owl:Class ; rdfs:label "Increased circulating free T3" ; rdfs:subClassOf obo:HP_0032209 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18258 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011789 obo:IAO_0000115 "Reduced sensitivity of thyroid follicle cells to stimulation by biologically active thyroid-stimulating hormone (TSH)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:32:33Z" ; oboInOwl:hasDbXref "UMLS:C4023189" ; oboInOwl:hasExactSynonym "TSHR defect", "Thyroid-stimulating hormone receptor defect" ; oboInOwl:id "HP:0011789" ; a owl:Class ; rdfs:label "Impaired sensitivity to thyroid stimulating hormone" ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0011790 obo:IAO_0000115 "Gain-of-function thyroid-stimulating hormone receptor (TSHR) defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:34:35Z" ; oboInOwl:hasDbXref "UMLS:C4023188" ; oboInOwl:hasExactSynonym "Activating TSHR defect" ; oboInOwl:id "HP:0011790" ; a owl:Class ; rdfs:label "Activating thyroid-stimulating hormone receptor defect" ; rdfs:subClassOf obo:HP_0011789 . obo:HP_0011791 obo:IAO_0000115 "Loss-of-function thyroid-stimulating hormone receptor (TSHR) defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:35:14Z" ; oboInOwl:hasDbXref "UMLS:C4023187" ; oboInOwl:hasExactSynonym "Inactivating TSHR defect" ; oboInOwl:id "HP:0011791" ; a owl:Class ; rdfs:label "Inactivating thyroid-stimulating hormone receptor defect" ; rdfs:subClassOf obo:HP_0011789 . obo:HP_0011792 obo:IAO_0000115 "Neoplasm categorized according to type of histological abnormality." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T06:57:50Z" ; oboInOwl:hasDbXref "UMLS:C4023186" ; oboInOwl:id "HP:0011792" ; a owl:Class ; rdfs:label "Neoplasm by histology" ; rdfs:subClassOf obo:HP_0002664 . obo:HP_0011793 obo:IAO_0000115 "Neoplasm categorized according to the anatomical site of origin of the neoplasm." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T07:00:13Z" ; oboInOwl:hasDbXref "UMLS:C4023185" ; oboInOwl:id "HP:0011793" ; a owl:Class ; rdfs:label "Neoplasm by anatomical site" ; rdfs:subClassOf obo:HP_0002664 . obo:HP_0011794 obo:IAO_0000115 "The presence of an embryonal neoplasm of the kidney that primarily affects children." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T07:44:34Z" ; oboInOwl:hasDbXref "UMLS:C4023184" ; oboInOwl:id "HP:0011794" ; a owl:Class ; rdfs:label "Embryonal renal neoplasm" ; rdfs:subClassOf obo:HP_0002898, obo:HP_0009726 . obo:HP_0011795 obo:IAO_0000115 "Presence of persistent islands of renal blastema in the postnatal kidney, anywhere within a renal lobe (a portion of a kidney consisting of a renal pyramid and the renal cortex above it)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T07:50:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:405934001", "UMLS:C1319016" ; oboInOwl:id "HP:0011795" ; a owl:Class ; rdfs:label "Intralobar nephroblastomatosis" ; rdfs:subClassOf obo:HP_0008643 . obo:HP_0011796 obo:IAO_0000115 "Abnormally persistent foci of embryonal immature blastema located in the superficial cortical region (perilobar)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T07:50:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:405935000", "UMLS:C1319017" ; oboInOwl:id "HP:0011796" ; a owl:Class ; rdfs:label "Perilobar nephroblastomatosis" ; rdfs:subClassOf obo:HP_0008643 . obo:HP_0011797 obo:IAO_0000115 "A type of papillary renal cell carcinoma that is characterized by small cuboidal cells covering thin papillae with a single line of uniform nuclei and small nucleoli." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T08:03:34Z" ; oboInOwl:hasDbXref "UMLS:C1336839" ; oboInOwl:id "HP:0011797" ; a owl:Class ; rdfs:label "Papillary renal cell carcinoma type 1" ; rdfs:subClassOf obo:HP_0006766 . obo:HP_0011798 obo:IAO_0000115 "A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm." ; dcterms:creator ; oboInOwl:creation_date "2012-04-22T08:13:36Z" ; oboInOwl:hasDbXref "MSH:C537750", "SNOMEDCT_US:254922006", "UMLS:C0346255" ; oboInOwl:id "HP:0011798" ; a owl:Class ; rdfs:comment "Renal oncocytoma is seen in Birt-Hogg-Dube syndrome (OMIM 135150)." ; rdfs:label "Renal oncocytoma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0011799 dcterms:creator ; oboInOwl:creation_date "2012-04-23T07:27:57Z" ; oboInOwl:hasDbXref "UMLS:C4023183" ; oboInOwl:hasExactSynonym "Abnormality of facial soft tissue", "Anomaly of facial soft tissue" ; oboInOwl:hasNarrowSynonym "Deformity of facial soft tissue", "Malformation of facial soft tissue" ; oboInOwl:id "HP:0011799" ; a owl:Class ; rdfs:label "Abnormality of facial soft tissue" ; rdfs:subClassOf obo:HP_0000271 . obo:HP_0011800 obo:IAO_0000115 "Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-24T07:46:05Z" ; oboInOwl:hasAlternativeId "HP:0040199" ; oboInOwl:hasBroadSynonym "Small midface" ; oboInOwl:hasDbXref "UMLS:C1853242", "UMLS:C2673410", "UMLS:C4280320", "UMLS:C4280321" ; oboInOwl:hasExactSynonym "Decreased size of midface", "Flat midface", "Hypoplasia of midface", "Midface deficiency", "Midface hypoplasia", "Midface retrusion", "Midface, flat", "Retrusive midface", "Underdevelopment of midface" ; oboInOwl:hasNarrowSynonym "Decreased projection of midface" ; oboInOwl:hasRelatedSynonym "Hypotrophic midface" ; oboInOwl:id "HP:0011800" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Midface retrusion" ; rdfs:subClassOf obo:HP_0000309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011801 obo:IAO_0000115 "Increased size of the parotid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-04-24T07:59:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:29748005", "UMLS:C0341047" ; oboInOwl:hasExactSynonym "Hyperplasia of parotid gland", "Increased size of parotid gland" ; oboInOwl:hasRelatedSynonym "Hypertrophy of parotid gland" ; oboInOwl:id "HP:0011801" ; a owl:Class ; rdfs:label "Enlargement of parotid gland" ; rdfs:subClassOf obo:HP_0000197 . obo:HP_0011802 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the tongue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-24T08:02:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253753005", "UMLS:C0431565" ; oboInOwl:hasExactSynonym "Lingual hamartoma" ; oboInOwl:id "HP:0011802" ; a owl:Class ; rdfs:label "Hamartoma of tongue" ; rdfs:subClassOf obo:HP_0100648 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011803 obo:IAO_0000115 "Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip." ; dcterms:creator ; oboInOwl:creation_date "2012-04-25T08:09:58Z" ; oboInOwl:hasDbXref "MSH:C535441", "SNOMEDCT_US:204521002", "UMLS:C0221363", "UMLS:C4280318", "UMLS:C4280319" ; oboInOwl:hasExactSynonym "Bifid nasal bridge", "Indentation or clefting of the nose" ; oboInOwl:hasRelatedSynonym "Cleft nasal bridge", "Cleft nose", "Indented bridge of nose" ; oboInOwl:id "HP:0011803" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This is a bundled term, but as it is useful in practice it is kept here. If it is only an indentation or cleft of the nasal tip, this should be coded as Bifid nasal tip." ; rdfs:label "Bifid nose" ; rdfs:subClassOf obo:HP_0004122 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011804 obo:IAO_0000115 "A functional abnormality of a skeletal muscle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-25T02:00:15Z" ; oboInOwl:hasDbXref "UMLS:C4023182" ; oboInOwl:hasExactSynonym "Abnormality of muscle physiology", "Issue with muscle function" ; oboInOwl:id "HP:0011804" ; a owl:Class ; rdfs:label "Abnormal muscle physiology" ; rdfs:subClassOf obo:HP_0003011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011805 obo:IAO_0000115 "A structural abnormality of a skeletal muscle." ; dcterms:creator ; oboInOwl:creation_date "2012-04-25T02:00:34Z" ; oboInOwl:hasAlternativeId "HP:0003735" ; oboInOwl:hasDbXref "UMLS:C4023181" ; oboInOwl:hasExactSynonym "Abnormal muscle morphology", "Abnormality of muscle morphology", "Abnormally shaped muscle", "Issue with muscle structure" ; oboInOwl:id "HP:0011805" ; a owl:Class ; rdfs:label "Abnormal skeletal muscle morphology" ; rdfs:subClassOf obo:HP_0003011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011807 obo:IAO_0000115 "Atrophy (wasting) affecting primary type 1 muscle fibers. This feature in general can only be observed on muscle biopsy." ; dcterms:creator ; oboInOwl:creation_date "2012-04-26T12:05:14Z" ; oboInOwl:hasDbXref "UMLS:C4023180" ; oboInOwl:hasExactSynonym "Type 1 muscle fibre atrophy" ; oboInOwl:id "HP:0011807" ; a owl:Class ; rdfs:label "Type 1 muscle fiber atrophy" ; rdfs:subClassOf obo:HP_0100295 . obo:HP_0011808 obo:IAO_0000115 "Decreased intensity of the patellar reflex (also known as the knee jerk reflex)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-27T08:38:22Z" ; oboInOwl:hasDbXref "UMLS:C3277184" ; oboInOwl:hasExactSynonym "Decreased knee jerk reflex", "Decreased patellar reflexes" ; oboInOwl:id "HP:0011808" ; a owl:Class ; rdfs:label "Decreased patellar reflex" ; rdfs:subClassOf obo:HP_0002600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011809 obo:IAO_0000115 "A type of myotonia that worsens with repeated muscle contractions." ; dcterms:creator ; oboInOwl:creation_date "2012-04-27T01:20:08Z" ; oboInOwl:hasDbXref "UMLS:C4023179" ; oboInOwl:id "HP:0011809" ; a owl:Class ; rdfs:comment "In classic myotonia the myotonia improves as muscles warm up, whereas in paradoxical myotonia (paramyotonia) it worsens with repeated muscle contractions." ; rdfs:label "Paradoxical myotonia" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0011810 obo:IAO_0000115 "A reduced ability to distinguish tactile sensations at points that are very close to one another. This can be tested by using special calipers whose points can be set from 2mm to several centimeters apart." ; dcterms:creator ; oboInOwl:creation_date "2012-04-28T02:50:12Z" ; oboInOwl:hasDbXref "UMLS:C4023178" ; oboInOwl:id "HP:0011810" ; a owl:Class ; rdfs:comment "A normal individual can sense about a 3 mm separation of points on the fingertips." ; rdfs:label "Impaired two-point discrimination" ; rdfs:subClassOf obo:HP_0011730 . obo:HP_0011811 obo:IAO_0000115 "A reduced ability to identify precisely the site of a touch. This test is usually carried out by asking a patient, whose eyes are closed or covered, to touch the same site with a fingertip." ; dcterms:creator ; oboInOwl:creation_date "2012-04-28T02:54:44Z" ; oboInOwl:hasDbXref "UMLS:C4021120" ; oboInOwl:hasExactSynonym "Impaired topognosis", "Impaired touch localisation" ; oboInOwl:id "HP:0011811" ; a owl:Class ; rdfs:label "Impaired touch localization" ; rdfs:subClassOf obo:HP_0011730 . obo:HP_0011812 obo:IAO_0000115 "Impaired ability to recognize letters or numbers drawn by an examiner's fingertip on the patient's skin (the patients eyes are closed or covered throughout this examination)." ; dcterms:creator ; oboInOwl:creation_date "2012-04-28T02:56:29Z" ; oboInOwl:hasDbXref "UMLS:C1328618" ; oboInOwl:id "HP:0011812" ; a owl:Class ; rdfs:label "Agraphesthesia" ; rdfs:subClassOf obo:HP_0011730 . obo:HP_0011813 obo:IAO_0000115 "Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. This term pertains if there is an increase in the accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." ; dcterms:creator ; oboInOwl:creation_date "2012-04-28T03:17:57Z" ; oboInOwl:hasDbXref "UMLS:C4023177" ; oboInOwl:id "HP:0011813" ; a owl:Class ; rdfs:label "Increased cerebral lipofuscin" ; rdfs:subClassOf obo:HP_0007367 . obo:HP_0011814 obo:IAO_0000115 "The concentration of hypoxanthine in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2012-04-28T03:38:52Z" ; oboInOwl:hasDbXref "UMLS:C3810487" ; oboInOwl:id "HP:0011814" ; a owl:Class ; rdfs:label "Increased urinary hypoxanthine level" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011815 obo:IAO_0000115 "A congenital defect in the skull, whereby there is a protrusion of part of the cranial contents through a congenital defect in the cranium, usually covered with skin or mucous membrane. The term encephalocele refers to a subclass of these lesions in which brain tissue protrudes through the defect." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T09:04:09Z" ; oboInOwl:hasDbXref "MSH:D004677", "SNOMEDCT_US:253101008", "SNOMEDCT_US:48777005", "SNOMEDCT_US:55999004", "UMLS:C0014065" ; oboInOwl:id "HP:0011815" ; a owl:Class ; rdfs:comment "A cephalocele is a rare birth defect that is characterized by a sac-like mass protruding through a defective opening in the skull. The sac varies in size that typically consists of herniated meninges and brain tissue (meningoencephalocele or encephalocele) or fragments of disorganized neural tissue. Alternatively, the sac may contain only the meninges (cranial meningocele) or it may include part of the ventricle filled with CSF (encephalocystocele) covered by skin (from PMID:24931720)." ; rdfs:label "Cephalocele" ; rdfs:subClassOf obo:HP_0000929 . obo:HP_0011816 obo:IAO_0000115 "An encephalocele located between bregma and lambda." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T09:07:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253109005", "UMLS:C0431294" ; oboInOwl:id "HP:0011816" ; a owl:Class ; rdfs:label "Parietal encephalocele" ; rdfs:subClassOf obo:HP_0002084 . obo:HP_0011817 obo:IAO_0000115 "Basal encephalocele is an encephalocele that occurs along the cribriform plate or through the sphenoid bone. The mass may appear in the nasal cavity, nasopharynx, epipharynx, sphenoid sinus, posterior orbit, or pterygopalatine fossa. The important distinction from other types is that no external tumor is visible except in those rare instances of herniations so large that they protrude through the mouth or nares." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T09:14:34Z" ; oboInOwl:hasDbXref "UMLS:C4023176" ; oboInOwl:id "HP:0011817" ; a owl:Class ; rdfs:comment "The skull base is made up of the ethmoid, sphenoid, occipital, paired frontal, and paired parietal bones, and is subdivided into 3 regions: the anterior, middle, and posterior cranial fossae." ; rdfs:label "Basal encephalocele" ; rdfs:subClassOf obo:HP_0002084 . obo:HP_0011818 dcterms:creator ; oboInOwl:creation_date "2012-04-29T09:20:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253106003", "UMLS:C0431291" ; oboInOwl:hasExactSynonym "Naso-frontal encephalocele" ; oboInOwl:id "HP:0011818" ; a owl:Class ; rdfs:label "Nasofrontal encephalocele" ; rdfs:subClassOf obo:HP_0007330 . obo:HP_0011819 obo:IAO_0000115 "A cleft of the muscular (soft) portion of the palate that is covered by mucous membrane. Soft-palate submucous clefts are characterized by a midline deficiency or lack of muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T09:49:02Z" ; oboInOwl:hasDbXref "UMLS:C4023175" ; oboInOwl:hasExactSynonym "Partial thickness cleft soft palate", "Submucous cleft velum" ; oboInOwl:id "HP:0011819" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Often, submucous cleft palate is associated with bifid uvula, but this should be coded separately. The muscles of the soft palate may not function properly, leading to speech problems, middle ear disease, and swallowing difficulties." ; rdfs:label "Submucous cleft soft palate" ; rdfs:subClassOf obo:HP_0000185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003682 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011820 obo:IAO_0000115 "Absence of the normal opening of the choana (the posterior nasal aperture) as a result of an obstructing choanal membrane that may be thin and strandlike or thick and pluglike." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T01:12:43Z" ; oboInOwl:hasDbXref "UMLS:C4023174" ; oboInOwl:id "HP:0011820" ; a owl:Class ; rdfs:label "Membranous choanal atresia" ; rdfs:subClassOf obo:HP_0000453 . obo:HP_0011821 obo:IAO_0000115 "An abnormality of one or more of the set of bones that make up the facial skeleton." ; dcterms:creator ; oboInOwl:creation_date "2012-04-29T04:37:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:433096001", "UMLS:C2315229" ; oboInOwl:hasExactSynonym "Abnormality of facial skeleton", "Anomaly of facial skeleton" ; oboInOwl:hasNarrowSynonym "Abnormality of facial bones", "Anomaly of facial bones", "Deformity of facial skeleton", "Deformity of the facial bones", "Malformation of facial bones", "Malformation of facial skeleton" ; oboInOwl:id "HP:0011821" ; a owl:Class ; rdfs:comment "The facial skeleton comprises the mandible, maxilla, frontal bone, nasal bones, and zygoma, as well as the inferior nasal concha, the lacrimal bones, the palatine bone, and the vomer." ; rdfs:label "Abnormal facial skeleton morphology" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011156 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011822 obo:IAO_0000115 "Increased width of the midpoint of the mandible (mental protuberance) and overlying soft tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-04-30T08:23:35Z" ; oboInOwl:hasDbXref "UMLS:C4023172" ; oboInOwl:hasExactSynonym "Broad chin", "Increased width of chin", "Increased width of menton region", "Wide chin" ; oboInOwl:id "HP:0011822" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Broad chin" ; rdfs:subClassOf obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002359 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011823 obo:IAO_0000115 "Horizontal crease or fold situated below the vermilion border of the lower lip and above the fatty pad of the chin, with the face at rest." ; dcterms:creator ; oboInOwl:creation_date "2012-04-30T08:33:02Z" ; oboInOwl:hasDbXref "UMLS:C4023171" ; oboInOwl:hasExactSynonym "Chin with horizontal crease", "Chin with horizontal furrow", "Chin with horizontal groove", "Chin with horizontal sulcus", "Horizontal chin skin cleft", "Horizontal menton crease" ; oboInOwl:id "HP:0011823" ; a owl:Class ; rdfs:label "Chin with horizontal crease" ; rdfs:subClassOf obo:HP_0000306 . obo:HP_0011824 obo:IAO_0000115 "H-shaped crease in the fat pad of the chin." ; dcterms:creator ; oboInOwl:creation_date "2012-04-30T08:34:24Z" ; oboInOwl:hasDbXref "UMLS:C1860309" ; oboInOwl:hasExactSynonym "Chin with H-shaped crease", "Chin, H-Shaped Crease", "Chin, H-shaped groove", "H-shaped dimple of the chin" ; oboInOwl:id "HP:0011824" ; a owl:Class ; rdfs:comment "The H-shape must be distinguished from Vertical crease of the chin." ; rdfs:label "Chin with H-shaped crease" ; rdfs:subClassOf obo:HP_0000306 . obo:HP_0011825 obo:IAO_0000115 "Prominence of a triangular soft tissue area of the philtrum with the apex to the columella." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:32:31Z" ; oboInOwl:hasDbXref "UMLS:C4021119" ; oboInOwl:hasExactSynonym "Philtrum, Tented" ; oboInOwl:id "HP:0011825" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A tented philtrum may accompany a Smooth philtrum. If present this should be coded separately." ; rdfs:label "Tented philtrum" ; rdfs:subClassOf obo:HP_0000288 . obo:HP_0011826 obo:IAO_0000115 "Narrow ridge in the midline of the philtral groove." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:33:46Z" ; oboInOwl:hasDbXref "UMLS:C4021118" ; oboInOwl:hasExactSynonym "Philtrum with central raphe", "Philtrum with midline ridge", "Philtrum, midline raphe" ; oboInOwl:id "HP:0011826" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "The ridge may be very subtly elevated." ; rdfs:label "Philtrum with midline raphe" ; rdfs:subClassOf obo:HP_0000288 . obo:HP_0011827 obo:IAO_0000115 "Absence of the usual parallel position of philtral ridges." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:35:32Z" ; oboInOwl:hasDbXref "UMLS:C4021117" ; oboInOwl:hasExactSynonym "Asymmetric philtral columns", "Asymmetric philtral ridges", "Malaligned philtral columns", "Philtral Ridges, Malaligned" ; oboInOwl:id "HP:0011827" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hajnis [1972] has described downwards convergent, downwards divergent (trapezoid or triangular), convex (ovoid), and concave philtral configurations. Any of these findings may be coded using this term." ; rdfs:label "Malaligned philtral ridges" ; rdfs:subClassOf obo:HP_0000288 . obo:HP_0011828 obo:IAO_0000115 "Pit in the midline of the philtral groove." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:36:55Z" ; oboInOwl:hasDbXref "UMLS:C4021116" ; oboInOwl:hasExactSynonym "Central sinus of philtrum", "Philtrum, Midline Sinus" ; oboInOwl:id "HP:0011828" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Although congenital sinuses of the lips generally occur in the lower lip, in rare instances they may appear in the philtrum of the upper lip, commonly close to the insertion of the columella." ; rdfs:label "Midline sinus of philtrum" ; rdfs:subClassOf obo:HP_0000288 . obo:HP_0011829 obo:IAO_0000115 "Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations below the mean. Alternatively, an apparently decreased distance between the ridges of the philtrum." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:38:12Z" ; oboInOwl:hasDbXref "UMLS:C4021115" ; oboInOwl:hasExactSynonym "Decreased breadth of philtrum", "Decreased horizontal dimension of philtrum", "Decreased transverse dimension of philtrum", "Decreased width of philtrum", "Philtrum, Narrow", "Thin philtrum" ; oboInOwl:id "HP:0011829" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Although congenital sinuses of the lips generally occur in the lower lip, in rare instances they may appear in the philtrum of the upper lip, commonly close to the insertion of the columella." ; rdfs:label "Narrow philtrum" ; rdfs:subClassOf obo:HP_0000288 . obo:HP_0011830 obo:IAO_0000115 "Abnormality of the oral mucosa." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T10:43:40Z" ; oboInOwl:hasDbXref "UMLS:C4023170" ; oboInOwl:hasExactSynonym "Abnormality of lining of mouth", "Abnormality of mucosa of mouth", "Abnormality of oral mucosa", "Abnormality of oral mucous membrane" ; oboInOwl:id "HP:0011830" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal oral mucosa morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003729 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011831 obo:IAO_0000115 "Nasal tip positioned to one side of the midline." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T07:37:48Z" ; oboInOwl:hasDbXref "UMLS:C4021114", "UMLS:C4280271" ; oboInOwl:hasExactSynonym "Asymmetry of nasal tip", "Asymmetry of tip of nose", "Crooked nasal tip", "Crooked tip of nose", "Deviated nasal tip", "Deviated tip of nose", "Nasal tip, deviated" ; oboInOwl:hasNarrowSynonym "Distortion of the nasal tip" ; oboInOwl:id "HP:0011831" ; a owl:Class ; rdfs:comment "There is no specific minimal angle before the tip can be determined to be deviated. The assessment of a mild degree of deviation is highly dependant on the experience of the observer. A deviated nasal septum can accompany a deviated nasal tip." ; rdfs:label "Deviated nasal tip" ; rdfs:subClassOf obo:HP_0000436 . obo:HP_0011832 obo:IAO_0000115 "Decrease in width of the nasal tip." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T07:39:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249331008", "UMLS:C0426433" ; oboInOwl:hasExactSynonym "Narrow nasal tip", "Narrow tip of nose", "Nasal tip, narrow", "Nasal tip, pinched", "Pinched nasal tip", "Pinched tip of nose", "Thin nasal tip", "Thin tip of nose" ; oboInOwl:id "HP:0011832" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Nasal tip width is assessed at the anterior junction of the alae and the tip. This is easier in persons with a somewhat squared shape of the nasal tip. This may be best viewed from the inferior aspect of the nose. No objective measures are available." ; rdfs:label "Narrow nasal tip" ; rdfs:subClassOf obo:HP_0000436 . obo:HP_0011833 obo:IAO_0000115 "Positioning of the nasal tip inferior to the nasal base." ; dcterms:creator ; oboInOwl:creation_date "2012-05-01T07:42:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249328007", "UMLS:C0426430" ; oboInOwl:hasExactSynonym "Drooping nasal tip", "Hooked tip of nose", "Low hanging nasal tip", "Nasal tip, overhanging", "Overhanging nasal tip" ; oboInOwl:id "HP:0011833" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This finding is often associated with a long nasal ridge. It is best appreciated in profile. This may also coexist with a Depressed nasal tip and Low insertion of the columella and should be coded separately." ; rdfs:label "Overhanging nasal tip" ; rdfs:subClassOf obo:HP_0000436 . obo:HP_0011834 obo:IAO_0000115 "A noninflammatory, progressive occlusion of the intracranial carotid arteries owing to the formation of netlike collateral arteries arising from the circle of Willis." ; dcterms:creator ; oboInOwl:creation_date "2012-05-05T03:24:26Z" ; oboInOwl:hasDbXref "UMLS:C4023169" ; oboInOwl:id "HP:0011834" ; a owl:Class ; rdfs:comment "Cerebral angiography shows puff-of-smoke (moyamoya) collaterals at the base of the brain." ; rdfs:label "Moyamoya phenomenon" ; rdfs:subClassOf obo:HP_0009145 . obo:HP_0011835 obo:IAO_0000115 "Congenital absence of the scaphoid.." ; dcterms:creator ; oboInOwl:creation_date "2012-05-05T07:37:35Z" ; oboInOwl:hasDbXref "UMLS:C1847189" ; oboInOwl:hasExactSynonym "Missing scaphoid bone" ; oboInOwl:hasRelatedSynonym "Absent scaphoid bone" ; oboInOwl:id "HP:0011835" ; a owl:Class ; rdfs:label "Absent scaphoid" ; rdfs:subClassOf obo:HP_0004231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001427 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011836 obo:IAO_0000115 "Delayed maturation and calcification of the talus." ; dcterms:creator ; oboInOwl:creation_date "2012-05-05T08:39:24Z" ; oboInOwl:hasDbXref "UMLS:C4023168" ; oboInOwl:id "HP:0011836" ; a owl:Class ; rdfs:label "Delayed talus ossification" ; rdfs:subClassOf obo:HP_0008365, obo:HP_0008369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011837 obo:IAO_0000115 "Detectable but decreased IgA levels that are more than 2 standard deviations below normal age-adjusted means." ; dcterms:creator ; oboInOwl:creation_date "2012-05-06T09:42:01Z" ; oboInOwl:hasDbXref "UMLS:C4023167" ; oboInOwl:id "HP:0011837" ; a owl:Class ; rdfs:label "Partial IgA deficiency" ; rdfs:subClassOf obo:HP_0002720 . obo:HP_0011838 obo:IAO_0000115 "Localized thickening and tightness of the skin of the fingers or toes." ; dcterms:creator ; oboInOwl:creation_date "2012-05-06T10:04:27Z" ; oboInOwl:hasDbXref "ICD-10:L94.3", "SNOMEDCT_US:201051000", "SNOMEDCT_US:298285004", "UMLS:C0150988" ; oboInOwl:id "HP:0011838" ; a owl:Class ; rdfs:label "Sclerodactyly" ; rdfs:subClassOf obo:HP_0001072 . obo:HP_0011839 obo:IAO_0000115 "A deviation from the normal count of T cells." ; dcterms:creator ; oboInOwl:creation_date "2012-05-06T10:43:44Z" ; oboInOwl:hasDbXref "UMLS:C4021113" ; oboInOwl:hasExactSynonym "Abnormal number of T cells", "Abnormality of T cell number" ; oboInOwl:id "HP:0011839" ; a owl:Class ; rdfs:label "Abnormal T cell count" ; rdfs:subClassOf obo:HP_0002843, obo:HP_0040088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011840 obo:IAO_0000115 "A functional anomaly of T cells." ; dcterms:creator ; oboInOwl:creation_date "2012-05-06T10:44:50Z" ; oboInOwl:hasAlternativeId "HP:0005402" ; oboInOwl:hasDbXref "UMLS:C4023166" ; oboInOwl:id "HP:0011840" ; a owl:Class ; rdfs:label "Abnormality of T cell physiology" ; rdfs:subClassOf obo:HP_0031409 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011841 obo:IAO_0000115 "A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance." ; dcterms:creator ; oboInOwl:creation_date "2012-05-06T06:46:54Z" ; oboInOwl:hasDbXref "MSH:D054141", "SNOMEDCT_US:111288001", "UMLS:C0152173" ; oboInOwl:id "HP:0011841" ; a owl:Class ; rdfs:comment "If untreated, ventricular flutter typically progresses to ventricular fibrillation." ; rdfs:label "Ventricular flutter" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0011842 obo:IAO_0000115 "An abnormality of the form, structure, or size of the skeletal system." ; dcterms:creator ; oboInOwl:creation_date "2012-05-07T08:08:37Z" ; oboInOwl:hasDbXref "UMLS:C4023165" ; oboInOwl:hasExactSynonym "Abnormality of skeletal morphology", "Abnormally shaped skeletal" ; oboInOwl:id "HP:0011842" ; a owl:Class ; rdfs:label "Abnormal skeletal morphology" ; rdfs:subClassOf obo:HP_0000924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001434 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011843 obo:IAO_0000115 "An abnormality of the function of the skeletal system." ; dcterms:creator ; oboInOwl:creation_date "2012-05-07T08:09:43Z" ; oboInOwl:hasDbXref "UMLS:C4023164" ; oboInOwl:hasExactSynonym "Abnormality of musculoskeletal physiology" ; oboInOwl:id "HP:0011843" ; a owl:Class ; rdfs:label "Abnormal musculoskeletal physiology" ; rdfs:subClassOf obo:HP_0000924, obo:HP_0033127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002204 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011844 obo:IAO_0000115 "An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles." ; dcterms:creator ; oboInOwl:creation_date "2012-05-07T08:12:26Z" ; oboInOwl:hasDbXref "UMLS:C4023163" ; oboInOwl:id "HP:0011844" ; a owl:Class ; rdfs:label "Abnormal appendicular skeleton morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011845 obo:IAO_0000115 "Short (hypoplastic) second metatarsal bone." ; dcterms:creator ; oboInOwl:creation_date "2012-05-08T07:36:00Z" ; oboInOwl:hasDbXref "UMLS:C4023162" ; oboInOwl:hasExactSynonym "Short 2nd long bone of foot" ; oboInOwl:id "HP:0011845" ; a owl:Class ; rdfs:label "Short second metatarsal" ; rdfs:subClassOf obo:HP_0010743, obo:HP_0040034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003651 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011846 obo:IAO_0000115 "A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-05-09T08:34:41Z" ; oboInOwl:hasDbXref "MSH:D018215", "SNOMEDCT_US:55333008", "UMLS:C0029417" ; oboInOwl:id "HP:0011846" ; a owl:Class ; rdfs:label "Osteoblastoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0011847 obo:IAO_0000115 "A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts." ; dcterms:creator ; oboInOwl:creation_date "2012-05-09T08:35:52Z" ; oboInOwl:hasDbXref "MSH:D018212", "SNOMEDCT_US:57500000", "SNOMEDCT_US:697970009", "UMLS:C0206638" ; oboInOwl:hasExactSynonym "Giant cell tumour of bone" ; oboInOwl:id "HP:0011847" ; a owl:Class ; rdfs:label "Giant cell tumor of bone" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0011848 obo:IAO_0000115 "A type of abdominal pain that comes and goes in waves, most often starting and ending suddenly and being of severe intensity." ; dcterms:creator ; oboInOwl:creation_date "2012-05-12T07:17:45Z" ; oboInOwl:hasDbXref "MSH:D003085", "SNOMEDCT_US:9991008", "UMLS:C0232488" ; oboInOwl:id "HP:0011848" ; a owl:Class ; rdfs:comment "Colicky abdominal pain can be caused by kidney stones and gallstones, among other etiologies. This type of pain is thought to be caused by spasm, obstruction, or distension of any of the hollow viscera of the gastrointestinal system." ; rdfs:label "Abdominal colic" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0011849 obo:IAO_0000115 "Any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." ; dcterms:creator ; oboInOwl:creation_date "2012-05-15T07:39:58Z" ; oboInOwl:hasDbXref "MP:0008271", "UMLS:C4023161", "UMLS:C4280317" ; oboInOwl:hasRelatedSynonym "Abnormal bone maturation" ; oboInOwl:id "HP:0011849" ; a owl:Class ; rdfs:comment "All bones are formed by the replacement by osteocytes of mesenchyme-derived connective tissue. Intramembranous ossification refers to the direct replacement of primitive mesenchyme with bone, and is responsible for bones such as the calvarium (e.g., frontals, parietals, interparietal) and the clavicula. In endochondral ossification, the mesenchyme differentiates into a cartilaginous intermediate, which serves as a template (anlange) that is subsequently removed and replaced by bone. Most bones are formed via endochondral ossification, including those at the base of the skull, the vertebral column, pectoral and pelvic regions and long bones of the extremities. A reduction in the amount of mineralized bone compared with that expected for a given developmental age. In clinicakl parlance, reduced ossification and delayed ossification are often used synonymously, but in principle a bone delayed ossification in a child can display normal ossification at a later developmental stage. The HPO will therefore treat poor, reduced, and decreased officiation as synonymous, and delayed ossification as a specific kind of reduced ossification." ; rdfs:label "Abnormal bone ossification" ; rdfs:subClassOf obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011850 obo:IAO_0000115 "Inflammation of the parotid gland." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T10:33:44Z" ; oboInOwl:hasDbXref "MSH:D010309", "SNOMEDCT_US:14756005", "UMLS:C0030583" ; oboInOwl:id "HP:0011850" ; a owl:Class ; rdfs:label "Parotitis" ; rdfs:subClassOf obo:HP_0000197 . obo:HP_0011851 obo:IAO_0000115 "Accumulation of blood within the pericardial sac." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T10:43:03Z" ; oboInOwl:hasDbXref "MSH:D010490", "SNOMEDCT_US:23412002", "UMLS:C0019064" ; oboInOwl:id "HP:0011851" ; a owl:Class ; rdfs:label "Hemopericardium" ; rdfs:subClassOf obo:HP_0001698 . obo:HP_0011852 obo:IAO_0000115 "Accumulation of chyle (the whitish fluid taken up by the lacteals in the intestine, consisting of an emulsion of lymph and triglyceride fat thatpasses into the veins by the thoracic duct) in the pericardium. Chylopericardium is generally caused by obstruction of or trauma to the thoracic duct." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T10:44:29Z" ; oboInOwl:hasDbXref "MSH:D010490", "SNOMEDCT_US:233890005", "UMLS:C0242426" ; oboInOwl:id "HP:0011852" ; a owl:Class ; rdfs:label "Chylopericardium" ; rdfs:subClassOf obo:HP_0001698 . obo:HP_0011853 obo:IAO_0000115 "Accumulation of serous fluid (pale yellow and transparent fluid) in the pericardial sac." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T10:49:08Z" ; oboInOwl:hasDbXref "UMLS:C4023160" ; oboInOwl:id "HP:0011853" ; a owl:Class ; rdfs:label "Serous pericardial effusion" ; rdfs:subClassOf obo:HP_0001698 . obo:HP_0011854 obo:IAO_0000115 "Accumulation of blood in the peritoneal cavity owing to internal hemorrhage." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T10:55:34Z" ; oboInOwl:hasDbXref "MSH:D006465", "SNOMEDCT_US:443826006", "SNOMEDCT_US:45626005", "UMLS:C0019065", "UMLS:C0744735" ; oboInOwl:hasRelatedSynonym "Hematoperitoneum" ; oboInOwl:id "HP:0011854" ; a owl:Class ; rdfs:label "Hemoperitoneum" ; rdfs:subClassOf obo:HP_0002585 . obo:HP_0011855 obo:IAO_0000115 "Abnormal accumulation of fluid leading to swelling of the pharynx." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T11:02:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:2129002", "UMLS:C0236024" ; oboInOwl:hasExactSynonym "Pharyngeal oedema", "Swollen throat", "Throat swelling" ; oboInOwl:id "HP:0011855" ; a owl:Class ; rdfs:label "Pharyngeal edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011856 obo:IAO_0000115 "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T11:08:54Z" ; oboInOwl:hasDbXref "MSH:D010842", "SNOMEDCT_US:14077003", "UMLS:C0031873" ; oboInOwl:id "HP:0011856" ; a owl:Class ; rdfs:label "Pica" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0011857 obo:IAO_0000115 "A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T11:34:44Z" ; oboInOwl:hasDbXref "MSH:D010954", "SNOMEDCT_US:10639003", "SNOMEDCT_US:415112005", "UMLS:C0032131" ; oboInOwl:id "HP:0011857" ; a owl:Class ; rdfs:comment "Plasmacytoma often generalizes to multiple myeloma over the course of several years." ; rdfs:label "Plasmacytoma" ; rdfs:subClassOf obo:HP_0004377 . obo:HP_0011858 obo:IAO_0000115 "Decreased activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa." ; dcterms:creator ; oboInOwl:creation_date "2012-05-26T11:35:57Z" ; oboInOwl:hasDbXref "UMLS:C4023159" ; oboInOwl:hasExactSynonym "Low factor IX activity" ; oboInOwl:id "HP:0011858" ; a owl:Class ; rdfs:comment "Severe deficiency of factor IX underlies hemophilia B." ; rdfs:label "Reduced factor IX activity" ; rdfs:subClassOf obo:HP_0033062 . obo:HP_0011859 obo:IAO_0000115 "A type of keratitis characterized by inflammation in pinpoint areas of the corneal epithelium." ; dcterms:creator ; oboInOwl:creation_date "2012-05-21T12:18:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:416300008", "UMLS:C1562761" ; oboInOwl:id "HP:0011859" ; a owl:Class ; rdfs:label "Punctate keratitis" ; rdfs:subClassOf obo:HP_0000491 . obo:HP_0011860 obo:IAO_0000115 "The presence of spots or rounded patches of abnormally increased density of metaphyseal bone." ; dcterms:creator ; oboInOwl:creation_date "2012-05-26T04:09:07Z" ; oboInOwl:hasDbXref "UMLS:C4020907" ; oboInOwl:hasExactSynonym "Dappled metaphyseal sclerosis" ; oboInOwl:id "HP:0011860" ; a owl:Class ; rdfs:comment "This finding is characteristic of Strudwick type of spondyloepimetaphyseal dysplasia." ; rdfs:label "Metaphyseal dappling" ; rdfs:subClassOf obo:HP_0004979 . obo:HP_0011861 obo:IAO_0000115 "Both lungs have three lobes. Normally, the left lung has two lobes, whereas the right lung has three lobes." ; dcterms:creator ; oboInOwl:creation_date "2012-05-27T01:09:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:448648001", "UMLS:C3164377" ; oboInOwl:hasExactSynonym "Bilateral trilobed lungs" ; oboInOwl:id "HP:0011861" ; a owl:Class ; rdfs:label "Bilateral trilobed lung" ; rdfs:subClassOf obo:HP_0002101 . obo:HP_0011862 obo:IAO_0000115 "Any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." ; dcterms:creator ; oboInOwl:creation_date "2012-05-27T01:32:04Z" ; oboInOwl:hasDbXref "UMLS:C4023158" ; oboInOwl:id "HP:0011862" ; a owl:Class ; rdfs:label "Abnormal bone collagen fibril morphology" ; rdfs:subClassOf obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011863 obo:IAO_0000115 "Any anomaly in the formation of the bony substance of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2012-05-27T04:08:55Z" ; oboInOwl:hasAlternativeId "HP:0006624" ; oboInOwl:hasDbXref "UMLS:C1860243" ; oboInOwl:hasExactSynonym "Abnormal maturation of breastbone", "Sternal ossification center abnormalities", "Sternal ossification centre abnormalities" ; oboInOwl:id "HP:0011863" ; a owl:Class ; rdfs:comment "The sternum develops from two cartilaginous bars, situated one on either side of the median plane and connected with the cartilages of the upper nine ribs of its own side. During development, the two cartilaginous bars fuse with each other to form the cartilaginous sternum. This in turn is ossified from six centers: one in the manubrium, four in the body of the sternum, and one in the xiphoid process." ; rdfs:label "Abnormal sternal ossification" ; rdfs:subClassOf obo:HP_0000766, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011864 obo:IAO_0000115 "An abnormally increased diphosphate(4-) concentration in the blood. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate." ; dcterms:creator ; oboInOwl:creation_date "2012-05-28T06:05:24Z" ; oboInOwl:hasDbXref "UMLS:C4023157" ; oboInOwl:id "HP:0011864" ; a owl:Class ; rdfs:label "Elevated plasma pyrophosphate" ; rdfs:subClassOf obo:HP_0100529 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011867 obo:IAO_0000115 "An anomaly of the ilium ala. This is the large expanded portion of the ilum which bounds the greater pelvis laterally." ; dcterms:creator ; oboInOwl:creation_date "2012-05-28T07:23:30Z" ; oboInOwl:hasDbXref "UMLS:C4023156" ; oboInOwl:hasExactSynonym "Abnormality of the wing of the ilium" ; oboInOwl:id "HP:0011867" ; a owl:Class ; rdfs:label "Abnormal iliac wing morphology" ; rdfs:subClassOf obo:HP_0002867 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011868 obo:IAO_0000115 "Pain in the lower back and hip radiating in the distribution of the sciatic nerve." ; dcterms:creator ; oboInOwl:creation_date "2012-05-28T10:34:09Z" ; oboInOwl:hasDbXref "MSH:D012585", "SNOMEDCT_US:23056005", "UMLS:C0036396" ; oboInOwl:id "HP:0011868" ; a owl:Class ; rdfs:label "Sciatica" ; rdfs:subClassOf obo:HP_0003418 . obo:HP_0011869 obo:IAO_0000115 "Any anomaly in the function of thrombocytes." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T05:32:11Z" ; oboInOwl:hasDbXref "UMLS:C0855740" ; oboInOwl:id "HP:0011869" ; a owl:Class ; rdfs:label "Abnormal platelet function" ; rdfs:subClassOf obo:HP_0001872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011870 obo:IAO_0000115 "Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T05:37:07Z" ; oboInOwl:hasDbXref "UMLS:C4023155" ; oboInOwl:id "HP:0011870" ; a owl:Class ; rdfs:label "Impaired arachidonic acid-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0011871 obo:IAO_0000115 "Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T05:39:52Z" ; oboInOwl:hasDbXref "UMLS:C4023154" ; oboInOwl:id "HP:0011871" ; a owl:Class ; rdfs:label "Impaired ristocetin-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540, obo:HP_0012146 . obo:HP_0011872 obo:IAO_0000115 "Abnormal response to thrombin or thrombin mimetics as manifested by reduced or lacking aggregation of platelets upon addition of thrombin (or thrombin mimetics)." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T05:41:52Z" ; oboInOwl:hasDbXref "UMLS:C4023153" ; oboInOwl:id "HP:0011872" ; a owl:Class ; rdfs:label "Impaired thrombin-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0011873 obo:IAO_0000115 "Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T08:11:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165558001", "UMLS:C0580317" ; oboInOwl:id "HP:0011873" ; a owl:Class ; rdfs:label "Abnormal platelet count" ; rdfs:subClassOf obo:HP_0011875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011874 obo:IAO_0000115 "Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin." ; dcterms:creator ; oboInOwl:creation_date "2012-05-30T08:31:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:73397007", "UMLS:C0272285" ; oboInOwl:id "HP:0011874" ; a owl:Class ; rdfs:comment "A delay of 5-10 days following administration of heparin is common in patients with no previous (or remote) exposure to heparin, but the drop in platelet count may be precipitous in patients with recent exposure. Heparin-induced thrombocytopenia is caused by antibodies against platelet factor 4." ; rdfs:label "Heparin-induced thrombocytopenia" ; rdfs:subClassOf obo:HP_0001873 . obo:HP_0011875 obo:IAO_0000115 "An anomaly in platelet form, ultrastructure, or intracellular organelles." ; dcterms:creator ; oboInOwl:creation_date "2012-05-31T03:43:59Z" ; oboInOwl:hasDbXref "UMLS:C0855742" ; oboInOwl:hasExactSynonym "Abnormal shape of platelets" ; oboInOwl:id "HP:0011875" ; a owl:Class ; rdfs:label "Abnormal platelet morphology" ; rdfs:subClassOf obo:HP_0001872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011876 obo:IAO_0000115 "Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers." ; dcterms:creator ; oboInOwl:creation_date "2012-05-31T03:46:13Z" ; oboInOwl:hasDbXref "UMLS:C4023152" ; oboInOwl:id "HP:0011876" ; a owl:Class ; rdfs:label "Abnormal platelet volume" ; rdfs:subClassOf obo:HP_0011875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000918 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011877 obo:IAO_0000115 "Average platelet volume above the upper limit of the normal reference interval." ; dcterms:creator ; oboInOwl:creation_date "2012-05-31T03:58:17Z" ; oboInOwl:hasDbXref "UMLS:C1096367" ; oboInOwl:hasExactSynonym "Large platelets" ; oboInOwl:id "HP:0011877" ; a owl:Class ; rdfs:comment "Mean platelet volume (MPV) is a measure of the average size of platelets, with a typical reference range of 7.5 to 11.5 femtoliters (fL)." ; rdfs:label "Increased mean platelet volume" ; rdfs:subClassOf obo:HP_0011876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011878 obo:IAO_0000115 "Presence of reduced amount of a membrane protein on the cell membrane of platelets. This feature is typically measured by flow cytometry." ; dcterms:creator ; oboInOwl:creation_date "2012-05-31T04:00:21Z" ; oboInOwl:hasDbXref "UMLS:C4023151" ; oboInOwl:id "HP:0011878" ; a owl:Class ; rdfs:label "Abnormal platelet membrane protein expression" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0011879 obo:IAO_0000115 "Decreased cell membrane concentration of the glycoprotein complex Ib-IX-V." ; dcterms:creator ; oboInOwl:creation_date "2012-05-31T04:01:34Z" ; oboInOwl:hasDbXref "UMLS:C4023150" ; oboInOwl:id "HP:0011879" ; a owl:Class ; rdfs:comment "The glycoprotein Ib-IX-V complex forms a specific platelet membrane adhesion receptor, which binds the adhesive glycoprotein, von Willebrand factor (vWF), in the vessel wall or plasma." ; rdfs:label "Decreased platelet glycoprotein Ib-IX-V" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0011880 obo:IAO_0000115 "An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T04:49:50Z" ; oboInOwl:hasDbXref "UMLS:C4023149" ; oboInOwl:id "HP:0011880" ; a owl:Class ; rdfs:label "Acute disseminated intravascular coagulation" ; rdfs:subClassOf obo:HP_0005521 . obo:HP_0011881 obo:IAO_0000115 "Decreased cell membrane concentration of glycoprotein VI." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T09:17:33Z" ; oboInOwl:hasDbXref "UMLS:C4023148" ; oboInOwl:id "HP:0011881" ; a owl:Class ; rdfs:comment "The glycoprotein VI is a glycoprotein receptor for collagen." ; rdfs:label "Decreased platelet glycoprotein VI" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0011882 obo:IAO_0000115 "Decreased cell membrane concentration of P2Y12 receptor." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T09:18:58Z" ; oboInOwl:hasDbXref "UMLS:C4023147" ; oboInOwl:id "HP:0011882" ; a owl:Class ; rdfs:comment "The P2Y12 receptor is activated by ADP and plays a central role in platelet activation." ; rdfs:label "Decreased platelet P2Y12 receptor" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0011883 obo:IAO_0000115 "An anomaly of alpha or dense granules or platelet lysosomes." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T09:47:57Z" ; oboInOwl:hasDbXref "UMLS:C4023146" ; oboInOwl:id "HP:0011883" ; a owl:Class ; rdfs:comment "Platelets contain two classes of granule: the alpha granules and the dense granules. During platelet activation, the contents of the granules are discharged into the lumen of the open canalicular system, from which they are then released to the extracellular space." ; rdfs:label "Abnormal platelet granules" ; rdfs:subClassOf obo:HP_0011875 . obo:HP_0011884 obo:IAO_0000115 "Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T10:25:45Z" ; oboInOwl:hasDbXref "UMLS:C4023145" ; oboInOwl:id "HP:0011884" ; a owl:Class ; rdfs:label "Abnormal umbilical stump bleeding" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0011885 obo:IAO_0000115 "Bleeding from vessels of the various tissues of the eye." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T10:44:39Z" ; oboInOwl:hasDbXref "MSH:D005130", "SNOMEDCT_US:417244000", "SNOMEDCT_US:93478000", "UMLS:C0015402" ; oboInOwl:hasExactSynonym "Bleeding from the eye", "Haemorrhage of the eye" ; oboInOwl:id "HP:0011885" ; a owl:Class ; rdfs:label "Hemorrhage of the eye" ; rdfs:subClassOf obo:HP_0011029, obo:HP_0012373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011886 obo:IAO_0000115 "Bleeding in the anterior chamber of the eye." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T10:49:36Z" ; oboInOwl:hasDbXref "MSH:D006988", "SNOMEDCT_US:75229002", "UMLS:C0020581" ; oboInOwl:id "HP:0011886" ; a owl:Class ; rdfs:label "Hyphema" ; rdfs:subClassOf obo:HP_0011885 . obo:HP_0011887 obo:IAO_0000115 "Hemorrhage from the vessels of the choroid." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T10:50:39Z" ; oboInOwl:hasDbXref "MSH:D002832", "SNOMEDCT_US:122003", "UMLS:C0008522" ; oboInOwl:hasExactSynonym "Choroid haemorrhage", "Choroidal haemorrhage", "Choroidal hemorrhage" ; oboInOwl:id "HP:0011887" ; a owl:Class ; rdfs:label "Choroid hemorrhage" ; rdfs:subClassOf obo:HP_0011885 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011888 obo:IAO_0000115 "Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4)." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T11:31:44Z" ; oboInOwl:hasDbXref "UMLS:C4023144" ; oboInOwl:hasExactSynonym "Bleeding requiring red cell transfusion" ; oboInOwl:id "HP:0011888" ; a owl:Class ; rdfs:label "Bleeding requiring red cell transfusion" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0011889 obo:IAO_0000115 "Significant bleeding or hemorrhage without significant precipitating factor." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T11:32:13Z" ; oboInOwl:hasDbXref "UMLS:C4023143" ; oboInOwl:hasExactSynonym "Bleeding with minor or no trauma", "Easy bleeding" ; oboInOwl:id "HP:0011889" ; a owl:Class ; rdfs:label "Bleeding with minor or no trauma" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0011890 obo:IAO_0000115 "Prolonged or protracted bleeding following an invasive procedure or intervention." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T11:33:38Z" ; oboInOwl:hasDbXref "UMLS:C4023142" ; oboInOwl:hasExactSynonym "Prolonged bleeding following procedure" ; oboInOwl:id "HP:0011890" ; a owl:Class ; rdfs:label "Prolonged bleeding following procedure" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0011891 obo:IAO_0000115 "Significant maternal haemorrhage/blood loss following deilvery of a child." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T11:35:46Z" ; oboInOwl:hasDbXref "MSH:D006473", "SNOMEDCT_US:47821001", "UMLS:C0032797" ; oboInOwl:hasExactSynonym "Bleeding post-delivery", "Post-partum haemorrhage" ; oboInOwl:id "HP:0011891" ; a owl:Class ; rdfs:label "Post-partum hemorrhage" ; rdfs:subClassOf obo:HP_0011890 . obo:HP_0011892 obo:IAO_0000115 "A reduced concentration of vitamin K." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T05:21:14Z" ; oboInOwl:hasDbXref "MSH:D014813", "SNOMEDCT_US:52675005", "UMLS:C0042880" ; oboInOwl:id "HP:0011892" ; a owl:Class ; rdfs:label "Low levels of vitamin K" ; rdfs:subClassOf obo:HP_0100831 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_28384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011893 obo:IAO_0000115 "Number of leukocytes per volume of blood beyond normal limits." ; dcterms:creator ; oboInOwl:creation_date "2012-06-02T05:32:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165509000", "UMLS:C0580531" ; oboInOwl:hasExactSynonym "Abnormal white blood cell count" ; oboInOwl:id "HP:0011893" ; a owl:Class ; rdfs:label "Abnormal leukocyte count" ; rdfs:subClassOf obo:HP_0001881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011894 obo:IAO_0000115 "Abnormal response to thromboxane as manifested by reduced or lacking aggregation of platelets upon addition of thromboxane A2 receptor agonists." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T08:51:33Z" ; oboInOwl:hasDbXref "UMLS:C4023141" ; oboInOwl:id "HP:0011894" ; a owl:Class ; rdfs:label "Impaired thromboxane A2 agonist-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0011895 obo:IAO_0000115 "A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T09:26:17Z" ; oboInOwl:hasDbXref "UMLS:C4021112" ; oboInOwl:hasExactSynonym "Anaemia due to reduced life span of red cells" ; oboInOwl:id "HP:0011895" ; a owl:Class ; rdfs:label "Anemia due to reduced life span of red cells" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0011896 obo:IAO_0000115 "Bleeding beneath the mucous membrane that lines the inner surface of the eyelid." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:11:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:78768009", "UMLS:C0038534" ; oboInOwl:hasExactSynonym "Subconjunctival haemorrhage" ; oboInOwl:id "HP:0011896" ; a owl:Class ; rdfs:label "Subconjunctival hemorrhage" ; rdfs:subClassOf obo:HP_0011885 . obo:HP_0011897 obo:IAO_0000115 "Increased number of neutrophils circulating in blood." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:16:43Z" ; oboInOwl:hasDbXref "UMLS:C4023140" ; oboInOwl:hasExactSynonym "Increased blood neutrophil counts" ; oboInOwl:id "HP:0011897" ; a owl:Class ; rdfs:label "Neutrophilia" ; rdfs:subClassOf obo:HP_0011991 . obo:HP_0011898 obo:IAO_0000115 "An abnormality of the level of activity of circulating fibrinogen." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:35:43Z" ; oboInOwl:hasDbXref "UMLS:C4023139" ; oboInOwl:id "HP:0011898" ; a owl:Class ; rdfs:comment "Fibrinogen is an essential hemostatic factor that is converted to fibrin (a final product of the hemostatic pathway) by activated thrombin." ; rdfs:label "Abnormality of circulating fibrinogen" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0011899 obo:IAO_0000115 "Increased concentration of fibrinogen in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:38:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:439000005", "UMLS:C0919890" ; oboInOwl:id "HP:0011899" ; a owl:Class ; rdfs:label "Hyperfibrinogenemia" ; rdfs:subClassOf obo:HP_0011898 . obo:HP_0011900 obo:IAO_0000115 "Decreased concentration of fibrinogen in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:39:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:234457009", "UMLS:C0553681" ; oboInOwl:hasExactSynonym "Low fibrinogen activity", "Low fibrinogen level" ; oboInOwl:id "HP:0011900" ; a owl:Class ; rdfs:label "Hypofibrinogenemia" ; rdfs:subClassOf obo:HP_0011898 . obo:HP_0011901 obo:IAO_0000115 "Qualitatively abnormal fibrinogen." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:40:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:111589005", "UMLS:C1260903" ; oboInOwl:hasExactSynonym "Dysfibrinogenaemia" ; oboInOwl:id "HP:0011901" ; a owl:Class ; rdfs:label "Dysfibrinogenemia" ; rdfs:subClassOf obo:HP_0011898 . obo:HP_0011902 obo:IAO_0000115 "Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T03:53:23Z" ; oboInOwl:hasDbXref "UMLS:C0349705" ; oboInOwl:hasExactSynonym "Abnormal Hb", "Abnormal haemoglobin" ; oboInOwl:id "HP:0011902" ; a owl:Class ; rdfs:label "Abnormal hemoglobin" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CHEBI_35143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011903 obo:IAO_0000115 "Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T04:59:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:48553001", "UMLS:C3161174" ; oboInOwl:hasExactSynonym "Haemoglobin H", "HbH haemoglobin", "Hemoglobin H" ; oboInOwl:id "HP:0011903" ; a owl:Class ; rdfs:label "HbH hemoglobin" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0011904 obo:IAO_0000115 "Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T05:03:00Z" ; oboInOwl:hasDbXref "UMLS:C0239941" ; oboInOwl:hasExactSynonym "Increased haemoglobin F", "Increased hemoglobin F", "Persistence of HbF", "Persistence of haemoglobin F" ; oboInOwl:id "HP:0011904" ; a owl:Class ; rdfs:label "Persistence of hemoglobin F" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0011905 obo:IAO_0000115 "Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T05:07:19Z" ; oboInOwl:hasDbXref "UMLS:C4023138" ; oboInOwl:hasExactSynonym "Reduced HbA", "Reduced haemoglobin A" ; oboInOwl:id "HP:0011905" ; a owl:Class ; rdfs:label "Reduced hemoglobin A" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0011906 obo:IAO_0000115 "A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T05:41:20Z" ; oboInOwl:hasDbXref "UMLS:C4023137" ; oboInOwl:id "HP:0011906" ; a owl:Class ; rdfs:label "Reduced beta/alpha synthesis ratio" ; rdfs:subClassOf obo:HP_0005560 . obo:HP_0011907 obo:IAO_0000115 "A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T05:43:45Z" ; oboInOwl:hasDbXref "UMLS:C4023136" ; oboInOwl:id "HP:0011907" ; a owl:Class ; rdfs:label "Reduced alpha/beta synthesis ratio" ; rdfs:subClassOf obo:HP_0005560 . obo:HP_0011908 obo:IAO_0000115 "Missing radius bone on one side only associated with congenital failure of development." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T06:46:52Z" ; oboInOwl:hasDbXref "UMLS:C4023135" ; oboInOwl:id "HP:0011908" ; a owl:Class ; rdfs:label "Unilateral radial aplasia" ; rdfs:subClassOf obo:HP_0003974 . obo:HP_0011909 obo:IAO_0000115 "Abnormally flat shape of the heads of the metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T10:23:40Z" ; oboInOwl:hasDbXref "UMLS:C4023134" ; oboInOwl:hasExactSynonym "Flattened head of long bone of hand" ; oboInOwl:id "HP:0011909" ; a owl:Class ; rdfs:comment "The metacarpal heads articulate with the proximal phalanges of the fingers." ; rdfs:label "Flattened metacarpal heads" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0011910 obo:IAO_0000115 "Abnormal reduction in length affecting all phalanges." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T10:50:44Z" ; oboInOwl:hasDbXref "UMLS:C4023133" ; oboInOwl:hasExactSynonym "Shortening of all finger bones" ; oboInOwl:id "HP:0011910" ; a owl:Class ; rdfs:label "Shortening of all phalanges of fingers" ; rdfs:subClassOf obo:HP_0009803 . obo:HP_0011911 obo:IAO_0000115 "An anomaly of a metacarpophalangeal joint." ; dcterms:creator ; oboInOwl:creation_date "2012-06-03T11:03:36Z" ; oboInOwl:hasDbXref "UMLS:C4023132" ; oboInOwl:hasExactSynonym "Abnormality of metacarpophalangeal joint", "Abnormality of the knuckle" ; oboInOwl:id "HP:0011911" ; a owl:Class ; rdfs:label "Abnormal metacarpophalangeal joint morphology" ; rdfs:subClassOf obo:HP_0005916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003695 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011912 obo:IAO_0000115 "An anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." ; dcterms:creator ; oboInOwl:creation_date "2012-06-05T08:51:23Z" ; oboInOwl:hasDbXref "UMLS:C4023131" ; oboInOwl:id "HP:0011912" ; a owl:Class ; rdfs:label "Abnormality of the glenoid fossa" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0003043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011913 obo:IAO_0000115 "Excessive, increased hair growth located in the lumbar region." ; dcterms:creator ; oboInOwl:creation_date "2012-06-05T10:13:10Z" ; oboInOwl:hasDbXref "UMLS:C4023130" ; oboInOwl:id "HP:0011913" ; a owl:Class ; rdfs:label "Lumbar hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0011914 obo:IAO_0000115 "Excessive, increased hair growth located in the thoracic region." ; dcterms:creator ; oboInOwl:creation_date "2012-06-05T10:13:14Z" ; oboInOwl:hasDbXref "UMLS:C4023129" ; oboInOwl:id "HP:0011914" ; a owl:Class ; rdfs:label "Thoracic hypertrichosis" ; rdfs:subClassOf obo:HP_0000998 . obo:HP_0011915 obo:IAO_0000115 "Abnormal calcification in the cardiovascular system." ; dcterms:creator ; oboInOwl:creation_date "2012-06-05T10:35:58Z" ; oboInOwl:hasDbXref "UMLS:C4023128" ; oboInOwl:id "HP:0011915" ; a owl:Class ; rdfs:label "Cardiovascular calcification" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0030680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011916 obo:IAO_0000115 "Atrophy of the extensor digitorum longus muscles, which mediate extension of the toes." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T06:59:44Z" ; oboInOwl:hasDbXref "UMLS:C4023127" ; oboInOwl:id "HP:0011916" ; a owl:Class ; rdfs:label "Toe extensor amyotrophy" ; rdfs:subClassOf obo:HP_0001436 . obo:HP_0011917 obo:IAO_0000115 "Underdevelopment (hypoplasia) of the fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T08:25:00Z" ; oboInOwl:hasDbXref "UMLS:C4021111" ; oboInOwl:hasExactSynonym "Short fifth toe", "Short little toe", "Short pinkie toe", "Short pinky toe" ; oboInOwl:id "HP:0011917" ; a owl:Class ; rdfs:label "Short 5th toe" ; rdfs:subClassOf obo:HP_0001831 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011918 obo:IAO_0000115 "Bending or curvature of a fourth toe in the tibial direction (i.e., towards the big toe)." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T08:44:27Z" ; oboInOwl:hasBroadSynonym "Curvature of 4th toe" ; oboInOwl:hasDbXref "UMLS:C4020740" ; oboInOwl:hasRelatedSynonym "4th toe clinodactyly" ; oboInOwl:id "HP:0011918" ; a owl:Class ; rdfs:label "Clinodactyly of the 4th toe" ; rdfs:subClassOf obo:HP_0001863, obo:HP_0010338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011919 obo:IAO_0000115 "Accumulation of pus in the pleural cavity." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T07:13:41Z" ; oboInOwl:hasDbXref "MSH:D016724", "SNOMEDCT_US:405950009", "SNOMEDCT_US:405951008", "SNOMEDCT_US:58554001", "UMLS:C0014013" ; oboInOwl:hasExactSynonym "Pyothorax" ; oboInOwl:id "HP:0011919" ; a owl:Class ; rdfs:label "Pleural empyema" ; rdfs:subClassOf obo:HP_0002202 . obo:HP_0011920 obo:IAO_0000115 "A type of pleural effusion with a transudate (extravascular fluid with low protein content and a low specific gravity). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T07:31:00Z" ; oboInOwl:hasDbXref "MSH:D006876", "SNOMEDCT_US:79231000", "UMLS:C0020312" ; oboInOwl:id "HP:0011920" ; a owl:Class ; rdfs:comment "Transudates result from imbalances in hydrostatic and oncotic forces and are caused by a limited number of recognized clinical conditions such as heart failure and cirrhosis. Less common causes include nephrotic syndrome, atelectasis, peritoneal dialysis, constrictive pericarditis, superior vena caval obstruction, and urinothorax." ; rdfs:label "Transudative pleural effusion" ; rdfs:subClassOf obo:HP_0002202 . obo:HP_0011921 obo:IAO_0000115 "A type of pleural effusion with a exudate (extravascular fluid that has exuded out of a tissue or its capillaries due to injury or inflammation). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T07:35:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:13841000119107", "UMLS:C3887491" ; oboInOwl:id "HP:0011921" ; a owl:Class ; rdfs:comment "Transudates result from pneumonia, malignancy, thromboembolism, and other causes." ; rdfs:label "Exudative pleural effusion" ; rdfs:subClassOf obo:HP_0002202 . obo:HP_0011922 obo:IAO_0000115 "An increased or decreased activity of the mitochondrial respiratory chain." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T08:57:44Z" ; oboInOwl:hasDbXref "UMLS:C4023126" ; oboInOwl:id "HP:0011922" ; a owl:Class ; rdfs:label "Abnormal activity of mitochondrial respiratory chain" ; rdfs:subClassOf obo:HP_0003287 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0008152 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005746 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011923 obo:IAO_0000115 "A reduction in the activity of the mitochondrial respiratory chain complex I, which is part of the electron transport chain in mitochondria." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T09:02:29Z" ; oboInOwl:hasDbXref "UMLS:C2677650", "UMLS:C4020739" ; oboInOwl:hasRelatedSynonym "Respiratory complex I deficiency" ; oboInOwl:id "HP:0011923" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial complex I" ; rdfs:subClassOf obo:HP_0008972 . obo:HP_0011924 obo:IAO_0000115 "A reduction in the activity of the mitochondrial respiratory chain complex III, which is part of the electron transport chain in mitochondria." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T09:04:26Z" ; oboInOwl:hasDbXref "UMLS:C3149083", "UMLS:C4020738" ; oboInOwl:hasRelatedSynonym "Respiratory complex III deficiency" ; oboInOwl:id "HP:0011924" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial complex III" ; rdfs:subClassOf obo:HP_0008972 . obo:HP_0011925 obo:IAO_0000115 "A reduction in the activity of the mitochondrial proton-transporting ATP synthase complex, which makes ATP via oxidative phosphorylation, and is sometimes described as Complex V of the electron transport chain." ; dcterms:creator ; oboInOwl:creation_date "2012-06-08T09:08:42Z" ; oboInOwl:hasDbXref "UMLS:C4020737", "UMLS:C4023125" ; oboInOwl:hasExactSynonym "Decreased activity of mitochondrial complex V", "Mitochondrial complex V deficiency" ; oboInOwl:hasRelatedSynonym "Respiratory complex deficiency, ATPase deficiency" ; oboInOwl:id "HP:0011925" ; a owl:Class ; rdfs:label "Decreased activity of mitochondrial ATP synthase complex" ; rdfs:subClassOf obo:HP_0008972 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011926 obo:IAO_0000115 "Proximal mislocalization of the big toe from its normal position." ; dcterms:creator ; oboInOwl:creation_date "2012-06-09T03:29:59Z" ; oboInOwl:hasDbXref "UMLS:C4021110" ; oboInOwl:hasExactSynonym "Proximal placement of big toe", "Proximally placed halluces" ; oboInOwl:id "HP:0011926" ; a owl:Class ; rdfs:comment "Thumb placement index greater than 0.55; or, the base of the thumb appears closer to the wrist than is typical. The technique for the thumb placement index is described in detail [Malina et al., 1973; Hall et al., 2007]. Briefly, the thumb placement index is the distance from the proximal crease of the index finger to the angle of the first interdigital space divided by the distance from the proximal crease of the index finger to the wrist flexion crease at the base of the thumb. This term should not be used with Preaxial polydactyly." ; rdfs:label "Proximal placement of hallux" ; rdfs:subClassOf obo:HP_0010051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002179 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011927 obo:IAO_0000115 "One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T09:18:42Z" ; oboInOwl:hasDbXref "UMLS:C1860176", "UMLS:C4023124" ; oboInOwl:hasExactSynonym "Short digit" ; oboInOwl:hasRelatedSynonym "Very short digits" ; oboInOwl:id "HP:0011927" ; a owl:Class ; rdfs:comment "Note that the term brachydactyly is reserved for specific patterns of short digits, see HP:0001156." ; rdfs:label "Short digit" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011928 obo:IAO_0000115 "Developmental hypoplasia (shortening) of proximal phalanx of toe." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T10:06:30Z" ; oboInOwl:hasDbXref "UMLS:C4023123" ; oboInOwl:hasExactSynonym "Short innermost toe bone" ; oboInOwl:id "HP:0011928" ; a owl:Class ; rdfs:label "Short proximal phalanx of toe" ; rdfs:subClassOf obo:HP_0001831, obo:HP_0010184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011929 obo:IAO_0000115 "Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T10:49:28Z" ; oboInOwl:hasDbXref "UMLS:C4023122" ; oboInOwl:id "HP:0011929" ; a owl:Class ; rdfs:comment "This anomaly is characteristic for brachydactyly type C." ; rdfs:label "Hypersegmentation of proximal phalanx of third finger" ; rdfs:subClassOf obo:HP_0009358 . obo:HP_0011930 dcterms:creator ; oboInOwl:creation_date "2012-06-10T11:37:14Z" ; oboInOwl:hasDbXref "UMLS:C4021836" ; oboInOwl:hasExactSynonym "Hyperelastic chest skin", "Stretchable chest skin" ; oboInOwl:id "HP:0011930" ; a owl:Class ; rdfs:label "Hyperextensible skin of chest" ; rdfs:subClassOf obo:HP_0007458 . obo:HP_0011931 obo:IAO_0000115 "An anomaly of the cerebellar peduncles. The superior, middle, and inferior cerebellar peduncles emerge from the cerebellum. The superior cerebellar penduncles connect the cerebellum to the midbrain, the middle cerebellar peduncles connect the cerebellum to the pons, and the inferior cerebellar peduncle connects the medulla spinalis and medulla oblongata with the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T01:02:57Z" ; oboInOwl:hasDbXref "UMLS:C4023121" ; oboInOwl:hasExactSynonym "Abnormality of the cerebellar peduncle" ; oboInOwl:id "HP:0011931" ; a owl:Class ; rdfs:label "Abnormal cerebellar peduncle morphology" ; rdfs:subClassOf obo:HP_0001317, obo:HP_0012501 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007416 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011932 obo:IAO_0000115 "An anomaly of the superior cerebellar peduncle." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T01:26:47Z" ; oboInOwl:hasDbXref "UMLS:C4023120" ; oboInOwl:hasExactSynonym "Abnormality of the superior cerebellar peduncle" ; oboInOwl:id "HP:0011932" ; a owl:Class ; rdfs:label "Abnormal superior cerebellar peduncle morphology" ; rdfs:subClassOf obo:HP_0007361, obo:HP_0011931 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011933 obo:IAO_0000115 "Increased length of the superior cerebellar peduncle." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T01:31:13Z" ; oboInOwl:hasDbXref "UMLS:C3810214", "UMLS:C4021109" ; oboInOwl:hasExactSynonym "Long cerebellar peduncle", "Long cerebellar peduncles" ; oboInOwl:hasRelatedSynonym "Elongated superior cerebellar peduncles" ; oboInOwl:id "HP:0011933" ; a owl:Class ; rdfs:label "Elongated superior cerebellar peduncle" ; rdfs:subClassOf obo:HP_0011932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011934 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery or superior mesenteric artery ." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T01:48:30Z" ; oboInOwl:hasDbXref "UMLS:C4023119" ; oboInOwl:hasNarrowSynonym "Mesenteric artery aneurysm" ; oboInOwl:id "HP:0011934" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of mesenteric artery" ; rdfs:subClassOf obo:HP_0002636 . obo:HP_0011935 obo:IAO_0000115 "Decreased concentration of urate in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T02:19:49Z" ; oboInOwl:hasDbXref "UMLS:C4023118" ; oboInOwl:id "HP:0011935" ; a owl:Class ; rdfs:comment "Xanthine oxidase oxidizes oxypurines such as xanthine and hypoxanthine to uric acid. Uric acid is the final oxidation product of purine catabolism." ; rdfs:label "Decreased urinary urate" ; rdfs:subClassOf obo:HP_0012610 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_46819 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011936 obo:IAO_0000115 "A decreased concentration of total carnitine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T04:20:17Z" ; oboInOwl:hasDbXref "UMLS:C4023117" ; oboInOwl:hasExactSynonym "Decreased plasma total carnitine" ; oboInOwl:id "HP:0011936" ; a owl:Class ; rdfs:label "Decreased plasma total carnitine" ; rdfs:subClassOf obo:HP_0003234 . obo:HP_0011937 obo:IAO_0000115 "Underdeveloped nails of the fifth toes." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T04:27:42Z" ; oboInOwl:hasDbXref "UMLS:C4023116" ; oboInOwl:hasExactSynonym "Small fifth toenail", "Underdeveloped fifth toenail" ; oboInOwl:id "HP:0011937" ; a owl:Class ; rdfs:label "Hypoplastic fifth toenail" ; rdfs:subClassOf obo:HP_0001800 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011282 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011939 obo:IAO_0000115 "A soft tissue continuity in the A/P axis between fingers 3 and 4." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T05:13:51Z" ; oboInOwl:hasDbXref "UMLS:C4023115" ; oboInOwl:id "HP:0011939" ; a owl:Class ; rdfs:label "3-4 finger cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0010554 . obo:HP_0011940 obo:IAO_0000115 "An abnormality of the shape of the thoracic vertebra T12 such that it is wedge-shaped (narrow towards the front)." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T06:07:54Z" ; oboInOwl:hasDbXref "UMLS:C4021108" ; oboInOwl:hasExactSynonym "Anterior wedging of the 12th thoracic vertebra", "Wedge-shaped 12th thoracic vertebra" ; oboInOwl:id "HP:0011940" ; a owl:Class ; rdfs:label "Anterior wedging of T12" ; rdfs:subClassOf obo:HP_0008422 . obo:HP_0011941 obo:IAO_0000115 "An abnormality of the shape of the lumbar vertebra L2 such that it is wedge-shaped (narrow towards the front)." ; dcterms:creator ; oboInOwl:creation_date "2012-06-10T06:10:08Z" ; oboInOwl:hasDbXref "UMLS:C4023114" ; oboInOwl:id "HP:0011941" ; a owl:Class ; rdfs:label "Anterior wedging of L2" ; rdfs:subClassOf obo:HP_0008422 . obo:HP_0011942 obo:IAO_0000115 "The concentration of SO3(2-), i.e., sulfite, in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2012-06-11T07:36:01Z" ; oboInOwl:hasDbXref "UMLS:C1848957" ; oboInOwl:id "HP:0011942" ; a owl:Class ; rdfs:label "Increased urinary sulfite level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0011943 obo:IAO_0000115 "Increased concentration of thiosulfate(2-) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-06-11T07:37:29Z" ; oboInOwl:hasDbXref "UMLS:C3148695" ; oboInOwl:id "HP:0011943" ; a owl:Class ; rdfs:label "Increased urinary thiosulfate" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011944 obo:IAO_0000115 "A type of vasculitis (inflammation of blood vessel walls) that affects blood vessels that are smaller than arteries, i.e., arterioles, venules, and capilllaries." ; dcterms:creator ; oboInOwl:creation_date "2012-06-11T07:58:21Z" ; oboInOwl:hasDbXref "UMLS:C4023113" ; oboInOwl:id "HP:0011944" ; a owl:Class ; rdfs:label "Small vessel vasculitis" ; rdfs:subClassOf obo:HP_0034784 . obo:HP_0011945 obo:IAO_0000115 "Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss." ; dcterms:creator ; oboInOwl:creation_date "2012-06-18T07:55:41Z" ; oboInOwl:hasDbXref "MSH:D018549", "SNOMEDCT_US:129458007", "UMLS:C0242770" ; oboInOwl:hasExactSynonym "BOOP", "Bronchiolitis obliterans organising pneumonia", "Cryptogenic organising pneumonia", "Cryptogenic organizing pneumonia" ; oboInOwl:id "HP:0011945" ; a owl:Class ; rdfs:label "Bronchiolitis obliterans organizing pneumonia" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0011946 obo:IAO_0000115 "Inflammation and fibrosis of the bronchioles leading to partial or complete obstruction of these airways." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:20:58Z" ; oboInOwl:hasDbXref "MSH:D001989", "SNOMEDCT_US:40100001", "UMLS:C0006272", "UMLS:C2350875" ; oboInOwl:hasExactSynonym "Constrictive bronchiolitis", "Obliterative bronchiolitis" ; oboInOwl:id "HP:0011946" ; a owl:Class ; rdfs:comment "Note that Bronchiolitis obliterans is not to be confused with the similarly named feature Bronchiolitis obliterans organizing pneumonia." ; rdfs:label "Bronchiolitis obliterans" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0011947 obo:IAO_0000115 "An infection of the upper or lower respiratory tract." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:26:36Z" ; oboInOwl:hasDbXref "MSH:D012141", "SNOMEDCT_US:275498002", "UMLS:C0035243" ; oboInOwl:hasExactSynonym "Respiratory infection", "Respiratory tract infection" ; oboInOwl:hasRelatedSynonym "Respiratory infections" ; oboInOwl:id "HP:0011947" ; a owl:Class ; rdfs:label "Respiratory tract infection" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0011948 obo:IAO_0000115 "A history of repeated acute infections of the upper or lower respiratory tract." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:30:15Z" ; oboInOwl:hasDbXref "UMLS:C1442786" ; oboInOwl:hasExactSynonym "Acute respiratory tract infection" ; oboInOwl:id "HP:0011948" ; a owl:Class ; rdfs:label "Recurrent acute respiratory tract infection" ; rdfs:subClassOf obo:HP_0002205 . obo:HP_0011949 obo:IAO_0000115 "Acute inflammation of the lung due to an infection." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:33:30Z" ; oboInOwl:hasDbXref "UMLS:C4023112" ; oboInOwl:id "HP:0011949" ; a owl:Class ; rdfs:label "Acute infectious pneumonia" ; rdfs:subClassOf obo:HP_0002090 . obo:HP_0011950 obo:IAO_0000115 "Inflammation of the bronchioles." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:36:11Z" ; oboInOwl:hasDbXref "MSH:D001988", "SNOMEDCT_US:4120002", "UMLS:C0006271" ; oboInOwl:id "HP:0011950" ; a owl:Class ; rdfs:label "Bronchiolitis" ; rdfs:subClassOf obo:HP_0011948 . obo:HP_0011951 obo:IAO_0000115 "Pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:40:03Z" ; oboInOwl:hasDbXref "MSH:D011015", "SNOMEDCT_US:422588002", "UMLS:C0032290" ; oboInOwl:id "HP:0011951" ; a owl:Class ; rdfs:label "Aspiration pneumonia" ; rdfs:subClassOf obo:HP_0002090 . obo:HP_0011952 obo:IAO_0000115 "An acute episode of pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:42:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:35031000119100", "UMLS:C4023111" ; oboInOwl:id "HP:0011952" ; a owl:Class ; rdfs:label "Acute aspiration pneumonia" ; rdfs:subClassOf obo:HP_0011951 . obo:HP_0011953 obo:IAO_0000115 "Lung parenchymal involvement with lymphoma." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T08:45:48Z" ; oboInOwl:hasDbXref "UMLS:C0519063" ; oboInOwl:id "HP:0011953" ; a owl:Class ; rdfs:label "Pulmonary lymphoma" ; rdfs:subClassOf obo:HP_0002665, obo:HP_0100526 . obo:HP_0011954 obo:IAO_0000115 "Diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrosis." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T09:06:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:65860006", "SNOMEDCT_US:715140008", "UMLS:C1318485" ; oboInOwl:hasExactSynonym "Nodular transformation of liver", "Noncirrhotic nodulation", "Partial nodular transformation of liver" ; oboInOwl:id "HP:0011954" ; a owl:Class ; rdfs:label "Nodular regenerative hyperplasia of liver" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0011955 obo:IAO_0000115 "The presence of multiple granulomas in the liver as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T09:11:32Z" ; oboInOwl:hasDbXref "UMLS:C4023110" ; oboInOwl:id "HP:0011955" ; a owl:Class ; rdfs:label "Hepatic granulomatosis" ; rdfs:subClassOf obo:HP_0002955, obo:HP_0410042 . obo:HP_0011956 obo:IAO_0000115 "A lymphoproliferative abnormality of the intestine characterized by numerous visible mucosal nodules measuring up to, and rarely exceeding, 0.5 cm in diameter Histologically, hyperplastic lymphoid follicles with large germinal centres are seen in the lamina propria and superficial submucosa. There is enlargement of the mucosal B cell follicles caused by hyperplasia of the follicle centres; surrounded by a normal appearing mantle zone. Disease may involve the stomach, the entire small intestine, and the large intestine." ; dcterms:creator ; oboInOwl:creation_date "2012-06-21T09:27:07Z" ; oboInOwl:hasDbXref "UMLS:C4023109" ; oboInOwl:id "HP:0011956" ; a owl:Class ; rdfs:label "Intestinal lymphoid nodular hyperplasia" ; rdfs:subClassOf obo:HP_0002242 . obo:HP_0011957 obo:IAO_0000115 "An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major." ; dcterms:creator ; oboInOwl:creation_date "2012-06-22T08:06:04Z" ; oboInOwl:hasDbXref "UMLS:C4023108" ; oboInOwl:hasExactSynonym "Abnormal pec muscles" ; oboInOwl:id "HP:0011957" ; a owl:Class ; rdfs:label "Abnormal pectoral muscle morphology" ; rdfs:subClassOf obo:HP_0009131 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011958 obo:IAO_0000115 "A small hole through the whole thickness of the retina." ; dcterms:creator ; oboInOwl:creation_date "2012-07-07T11:24:39Z" ; oboInOwl:hasDbXref "MSH:D012167", "SNOMEDCT_US:232003005", "SNOMEDCT_US:302888003", "SNOMEDCT_US:40024006", "SNOMEDCT_US:95690009", "UMLS:C0035321" ; oboInOwl:hasExactSynonym "Retinal tear", "Torn retina" ; oboInOwl:id "HP:0011958" ; a owl:Class ; rdfs:comment "Retinal perforations can be cause by inflammation, trauma, degeneration, or other factors, and comprise retinal breaks, tears, dialyses, and holes." ; rdfs:label "Retinal perforation" ; rdfs:subClassOf obo:HP_0000479 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011959 obo:IAO_0000115 "Hypoplasia (underdevelopment) of the pectoralis minor on only one side of the chest." ; dcterms:creator ; oboInOwl:creation_date "2012-06-22T08:13:12Z" ; oboInOwl:hasDbXref "UMLS:C4023107" ; oboInOwl:hasExactSynonym "Small pec muscle on one side", "Underdeveloped pec muscle on one side" ; oboInOwl:id "HP:0011959" ; a owl:Class ; rdfs:label "Unilateral hypoplasia of pectoralis major muscle" ; rdfs:subClassOf obo:HP_0011957 . obo:HP_0011960 obo:IAO_0000115 "Focal proliferation of glial cells in the substantia nigra." ; dcterms:creator ; oboInOwl:creation_date "2012-07-16T11:50:42Z" ; oboInOwl:hasDbXref "UMLS:C1846865" ; oboInOwl:id "HP:0011960" ; a owl:Class ; rdfs:label "Substantia nigra gliosis" ; rdfs:subClassOf obo:HP_0002171, obo:HP_0045007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002038 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011961 obo:IAO_0000115 "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy." ; dcterms:creator ; oboInOwl:creation_date "2012-07-16T12:22:54Z" ; oboInOwl:hasDbXref "UMLS:C4021107" ; oboInOwl:hasExactSynonym "Testicular azoospermia" ; oboInOwl:id "HP:0011961" ; a owl:Class ; rdfs:label "Non-obstructive azoospermia" ; rdfs:subClassOf obo:HP_0000027 . obo:HP_0011962 obo:IAO_0000115 "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy." ; dcterms:creator ; oboInOwl:creation_date "2012-07-16T12:25:35Z" ; oboInOwl:hasDbXref "UMLS:C4023106" ; oboInOwl:id "HP:0011962" ; a owl:Class ; rdfs:label "Obstructive azoospermia" ; rdfs:subClassOf obo:HP_0000027 . obo:HP_0011963 obo:IAO_0000115 "Absence of any measurable level of sperm in his semen, due to a hypothalamic or pituitary abnormality diagnosed with hypo-gonadotropic-hypogonadism. The diagnosis is made on the basis of low LH and FSH levels and low or normal testosterone levels." ; dcterms:creator ; oboInOwl:creation_date "2012-07-16T12:28:55Z" ; oboInOwl:hasDbXref "UMLS:C4023105" ; oboInOwl:id "HP:0011963" ; a owl:Class ; rdfs:label "Pretesticular azoospermia" ; rdfs:subClassOf obo:HP_0000027 . obo:HP_0011964 obo:IAO_0000115 "History of repeated intermittent involuntary muscle contractions that were painful." ; dcterms:creator ; oboInOwl:creation_date "2012-07-16T01:17:16Z" ; oboInOwl:hasDbXref "UMLS:C4023104" ; oboInOwl:id "HP:0011964" ; a owl:Class ; rdfs:label "Intermittent painful muscle spasms" ; rdfs:subClassOf obo:HP_0003394 . obo:HP_0011965 obo:IAO_0000115 "Any deviation from the normal concentration of citrulline in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:21:59Z" ; oboInOwl:hasDbXref "UMLS:C4023103" ; oboInOwl:id "HP:0011965" ; a owl:Class ; rdfs:comment "Citrulline is an alpha-amino acid that is a key intermediate in the urea cycle." ; rdfs:label "Abnormal circulating citrulline concentration" ; rdfs:subClassOf obo:HP_0033109 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0000052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011966 obo:IAO_0000115 "An increased concentration of citrulline in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:23:22Z" ; oboInOwl:hasDbXref "UMLS:C4023102" ; oboInOwl:id "HP:0011966" ; a owl:Class ; rdfs:label "Elevated plasma citrulline" ; rdfs:subClassOf obo:HP_0011965 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011967 obo:IAO_0000115 "A reduced concentration of copper in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:29:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19577007", "UMLS:C0268070" ; oboInOwl:hasExactSynonym "Copper deficiency", "Hypocupremia", "Reduced serum copper" ; oboInOwl:id "HP:0011967" ; a owl:Class ; rdfs:label "Decreased circulating copper concentration" ; rdfs:subClassOf obo:HP_0010836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011968 obo:IAO_0000115 "Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T10:25:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:78164000", "UMLS:C0232466" ; oboInOwl:hasExactSynonym "Feeding difficulties", "Feeding problems", "Poor feeding" ; oboInOwl:id "HP:0011968" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Feeding difficulties" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0011969 obo:IAO_0000115 "An elevated concentration of luteinizing hormone in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:36:09Z" ; oboInOwl:hasAlternativeId "HP:0030343" ; oboInOwl:hasDbXref "UMLS:C4023101" ; oboInOwl:hasExactSynonym "Elevated LH level", "Elevated luteinizing hormone", "Increased circulating luteinizing hormone level" ; oboInOwl:id "HP:0011969" ; a owl:Class ; rdfs:label "Elevated circulating luteinizing hormone level" ; rdfs:subClassOf obo:HP_0000837, obo:HP_0030345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_81568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011970 obo:IAO_0000115 "Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:39:48Z" ; oboInOwl:hasDbXref "MSH:D016657", "SNOMEDCT_US:230724001", "UMLS:C0085220" ; oboInOwl:id "HP:0011970" ; a owl:Class ; rdfs:comment "Vascular beta-amyloid deposition in the walls of small to medium-sized, blood vessels (mostly arterial) of the central nervous system. Cerebral amyloid angiopathy mostly occurs in the sporadic form in the elderly, while rare familial forms occur in younger patients and are generally lead to more severe clinical manifestations. Extracellular deposition of the amyloid protein in the brain is associated with neurologic and physiological disease progression." ; rdfs:label "Cerebral amyloid angiopathy" ; rdfs:subClassOf obo:HP_0011034 . obo:HP_0011971 obo:IAO_0000115 "An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor)." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:42:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:402410006", "SNOMEDCT_US:402601007", "SNOMEDCT_US:7632005", "UMLS:C0343065" ; oboInOwl:hasExactSynonym "Dermatographism", "Dermographism", "Skin writing" ; oboInOwl:id "HP:0011971" ; a owl:Class ; rdfs:label "Dermatographic urticaria" ; rdfs:subClassOf obo:HP_0410134 . obo:HP_0011972 obo:IAO_0000115 "Abnormally low glucose concentration in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:45:55Z" ; oboInOwl:hasDbXref "UMLS:C0598121" ; oboInOwl:hasExactSynonym "Decreased CSF glucose", "Low glucose levels in cerebral spinal fluid" ; oboInOwl:id "HP:0011972" ; a owl:Class ; rdfs:label "Hypoglycorrhachia" ; rdfs:subClassOf obo:HP_0031884 . obo:HP_0011973 obo:IAO_0000115 "Repeated episodes of sudden-onset and transient lethargy." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:48:06Z" ; oboInOwl:hasDbXref "UMLS:C1847507" ; oboInOwl:id "HP:0011973" ; a owl:Class ; rdfs:label "Paroxysmal lethargy" ; rdfs:subClassOf obo:HP_0001254 . obo:HP_0011974 obo:IAO_0000115 "Replacement of bone marrow by fibrous tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:51:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:52967002", "UMLS:C0026987" ; oboInOwl:id "HP:0011974" ; a owl:Class ; rdfs:label "Myelofibrosis" ; rdfs:subClassOf obo:HP_0012145 . obo:HP_0011975 obo:IAO_0000115 "Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T08:55:03Z" ; oboInOwl:hasDbXref "UMLS:C4023100" ; oboInOwl:id "HP:0011975" ; a owl:Class ; rdfs:comment "The ototoxicity of aminoglycoside antibiotics is related to the destruction of sensory hair cells in the cochlea and vestibular labyrinth." ; rdfs:label "Aminoglycoside-induced hearing loss" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0011976 obo:IAO_0000115 "The concentration of a catecholamine in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:07:22Z" ; oboInOwl:hasDbXref "UMLS:C0241577" ; oboInOwl:hasExactSynonym "Elevated urinary catecholamines" ; oboInOwl:id "HP:0011976" ; a owl:Class ; rdfs:label "Elevated urinary catecholamine level" ; rdfs:subClassOf obo:HP_0011281 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011977 obo:IAO_0000115 "An increased concentration of homovanillic acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:10:06Z" ; oboInOwl:hasDbXref "UMLS:C4020736" ; oboInOwl:hasRelatedSynonym "Increased urinary homovanillic acid" ; oboInOwl:id "HP:0011977" ; a owl:Class ; rdfs:comment "Homovanillic acid is the main metabolite produced from dopamine degradation by the action of monoamine oxidase. Increased levels of catecholamines or catecholamine metabolites, including dopamine, homovanillic acid (HVA) and/or vanillylmandelic acid (VMA), can be detected in the urine of 90% of all patients with neuroblastoma." ; rdfs:label "Elevated urinary homovanillic acid" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_545959 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011978 obo:IAO_0000115 "An increased concentration of vanillylmandelic acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:11:52Z" ; oboInOwl:hasDbXref "UMLS:C4020735" ; oboInOwl:hasRelatedSynonym "Increased urinary vanillylmandelic acid" ; oboInOwl:id "HP:0011978" ; a owl:Class ; rdfs:label "Elevated urinary vanillylmandelic acid" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_20106 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011979 obo:IAO_0000115 "The concentration of dopamine in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:13:16Z" ; oboInOwl:hasDbXref "UMLS:C4023099" ; oboInOwl:hasExactSynonym "Elevated urinary dopamine" ; oboInOwl:id "HP:0011979" ; a owl:Class ; rdfs:label "Elevated urinary dopamine level" ; rdfs:subClassOf obo:HP_0011976 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011980 obo:IAO_0000115 "Gallstones composed primarily of cholesterol, usually about 2-3 cm in length with an oval form and a yellow or green/brown color." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:16:15Z" ; oboInOwl:hasDbXref "UMLS:C0856727" ; oboInOwl:id "HP:0011980" ; a owl:Class ; rdfs:label "Cholesterol gallstones" ; rdfs:subClassOf obo:HP_0001081 . obo:HP_0011981 obo:IAO_0000115 "Gallstones composed primarily of bilirubin and calcium salts (calcium bilirubinate) with a low cholesterol concentration." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:18:44Z" ; oboInOwl:hasDbXref "UMLS:C3278865" ; oboInOwl:id "HP:0011981" ; a owl:Class ; rdfs:label "Pigment gallstones" ; rdfs:subClassOf obo:HP_0001081 . obo:HP_0011982 obo:IAO_0000115 "A type of pigment gallstone that is hard and black, containing calcium carbonate and calcium phosphates." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:25:05Z" ; oboInOwl:hasDbXref "UMLS:C4023098" ; oboInOwl:id "HP:0011982" ; a owl:Class ; rdfs:label "Black pigment gallstones" ; rdfs:subClassOf obo:HP_0011981 . obo:HP_0011983 obo:IAO_0000115 "A type of pigment gallstone that is brown, containing calcium fatty acids. These stones are softer than black pigment gallstones." ; dcterms:creator ; oboInOwl:creation_date "2012-07-18T09:26:55Z" ; oboInOwl:hasDbXref "UMLS:C4023097" ; oboInOwl:id "HP:0011983" ; a owl:Class ; rdfs:label "Brown pigment gallstones" ; rdfs:subClassOf obo:HP_0011981 . obo:HP_0011984 obo:IAO_0000115 "Failure of formation of the lumen of the gallbladder, often associated with gallbladder hypoplasia." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:26:35Z" ; oboInOwl:hasDbXref "UMLS:C3277945" ; oboInOwl:hasExactSynonym "Gallbladder atresia" ; oboInOwl:id "HP:0011984" ; a owl:Class ; rdfs:label "Atretic gallbladder" ; rdfs:subClassOf obo:HP_0011466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011985 obo:IAO_0000115 "Clay colored stools lacking bile pigment." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:31:22Z" ; oboInOwl:hasAlternativeId "HP:0200112" ; oboInOwl:hasDbXref "SNOMEDCT_US:70396004", "UMLS:C2675627" ; oboInOwl:hasExactSynonym "Acholia", "Clay colored stools", "Clay coloured stools", "Discolored, acholic stools" ; oboInOwl:id "HP:0011985" ; a owl:Class ; rdfs:label "Acholic stools" ; rdfs:subClassOf obo:HP_0001396, obo:HP_0031685 . obo:HP_0011986 obo:IAO_0000115 "Formation of abnormal, extraskeletal bony tissue, i.e., the presence of bone in soft tissue where bone normally does not exist." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:38:25Z" ; oboInOwl:hasDbXref "MEDDRA:10065453", "MSH:D009999", "SNOMEDCT_US:128491006", "UMLS:C0029396" ; oboInOwl:hasExactSynonym "Ectopic bone formation", "Heterotopic ossification" ; oboInOwl:id "HP:0011986" ; a owl:Class ; rdfs:label "Ectopic ossification" ; rdfs:subClassOf obo:HP_0011849 . obo:HP_0011987 obo:IAO_0000115 "Formation of abnormal bony tissue within muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:46:03Z" ; oboInOwl:hasDbXref "UMLS:C4023096" ; oboInOwl:hasExactSynonym "Calcification of muscle tissue" ; oboInOwl:id "HP:0011987" ; a owl:Class ; rdfs:label "Ectopic ossification in muscle tissue" ; rdfs:subClassOf obo:HP_0011986 . obo:HP_0011988 obo:IAO_0000115 "Formation of abnormal bony tissue within tendon tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:47:01Z" ; oboInOwl:hasDbXref "UMLS:C4023095" ; oboInOwl:id "HP:0011988" ; a owl:Class ; rdfs:label "Ectopic ossification in tendon tissue" ; rdfs:subClassOf obo:HP_0011986 . obo:HP_0011989 obo:IAO_0000115 "Formation of abnormal bony tissue within ligament tissue." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:48:31Z" ; oboInOwl:hasDbXref "UMLS:C4023094" ; oboInOwl:id "HP:0011989" ; a owl:Class ; rdfs:label "Ectopic ossification in ligament tissue" ; rdfs:subClassOf obo:HP_0011986 . obo:HP_0011990 obo:IAO_0000115 "A functional abnormality of neutrophils." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:56:37Z" ; oboInOwl:hasDbXref "UMLS:C4023093" ; oboInOwl:id "HP:0011990" ; a owl:Class ; rdfs:label "Abnormality of neutrophil physiology" ; rdfs:subClassOf obo:HP_0001874 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011991 obo:IAO_0000115 "A deviation from the normal range of neutrophil cell counts in the circulation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T10:59:14Z" ; oboInOwl:hasDbXref "UMLS:C4023092" ; oboInOwl:hasExactSynonym "Abnormal neutrophil cell number" ; oboInOwl:id "HP:0011991" ; a owl:Class ; rdfs:label "Abnormal neutrophil count" ; rdfs:subClassOf obo:HP_0001874, obo:HP_0032309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011992 obo:IAO_0000115 "An abnormal form or size of neutrophils." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T11:00:27Z" ; oboInOwl:hasDbXref "UMLS:C4023091" ; oboInOwl:id "HP:0011992" ; a owl:Class ; rdfs:label "Abnormality of neutrophil morphology" ; rdfs:subClassOf obo:HP_0001874 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011993 obo:IAO_0000115 "A reduction in the ability of neutrophils to kill bacteria." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T11:01:32Z" ; oboInOwl:hasDbXref "UMLS:C4023090" ; oboInOwl:id "HP:0011993" ; a owl:Class ; rdfs:label "Impaired neutrophil bactericidal activity" ; rdfs:subClassOf obo:HP_0011990 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070944 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ) ] ] . obo:HP_0011994 obo:IAO_0000115 "An abnormality of the interatrial septum." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T11:34:27Z" ; oboInOwl:hasDbXref "Fyler:2002", "SNOMEDCT_US:253363004", "UMLS:C0344722" ; oboInOwl:hasExactSynonym "Abnormal interatrial septum morphology", "Abnormality of the atrial septum" ; oboInOwl:id "HP:0011994" ; a owl:Class ; rdfs:label "Abnormal atrial septum morphology" ; rdfs:subClassOf obo:HP_0001671 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0011995 obo:IAO_0000115 "A bulging of the interatrial septum towards one side. In adults, atrial septal aneurysm can be defined as a protrusion of the aneurysm of >10 mm beyond the plane of the atrial septum as measured by transesophageal echocardiography." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T11:35:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95440004", "UMLS:C0521533" ; oboInOwl:hasNarrowSynonym "Atrial septal aneurysm" ; oboInOwl:id "HP:0011995" ; a owl:Class ; rdfs:comment "Atrial septal aneurysm formation may be secondary to raised interatrial pressure gradients, producing a bulging septal shift toward the low-pressure side. However, it has been also found in patients with normal atrial pressures, suggesting a primary (congenital) malformation." ; rdfs:label "Atrial septal dilatation" ; rdfs:subClassOf obo:HP_0011994 . obo:HP_0011996 obo:IAO_0000115 "Increased activity of coagulation factor V, Factor V, which is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T11:40:31Z" ; oboInOwl:hasDbXref "UMLS:C4021106" ; oboInOwl:hasExactSynonym "Elevated factor V activity", "Plasma factor V elevated" ; oboInOwl:id "HP:0011996" ; a owl:Class ; rdfs:label "Elevated coagulation factor V activity" ; rdfs:subClassOf obo:HP_0031899 . obo:HP_0011997 obo:IAO_0000115 "Abnormally increased level of blood lactate following a meal." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T12:06:39Z" ; oboInOwl:hasDbXref "UMLS:C4023089" ; oboInOwl:id "HP:0011997" ; a owl:Class ; rdfs:label "Postprandial hyperlactemia" ; rdfs:subClassOf obo:HP_0002151 . obo:HP_0011998 obo:IAO_0000115 "An increased concentration of glucose in the blood following a meal." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T12:07:59Z" ; oboInOwl:hasDbXref "MSH:D006943", "UMLS:C1855520" ; oboInOwl:id "HP:0011998" ; a owl:Class ; rdfs:label "Postprandial hyperglycemia" ; rdfs:subClassOf obo:HP_0003074 . obo:HP_0011999 obo:IAO_0000115 "A persecutory delusion of supposed hostility of others." ; dcterms:creator ; oboInOwl:creation_date "2012-07-19T01:00:23Z" ; oboInOwl:hasDbXref "MSH:D010259", "SNOMEDCT_US:191667009", "UMLS:C1456784" ; oboInOwl:hasExactSynonym "Paranoia" ; oboInOwl:id "HP:0011999" ; a owl:Class ; rdfs:label "Paranoia" ; rdfs:subClassOf obo:HP_0000746 . obo:HP_0012000 obo:IAO_0000115 "EEG with generalized sharp transient waves of a duration less than 80 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:39:52Z" ; oboInOwl:hasDbXref "UMLS:C2206531" ; oboInOwl:hasExactSynonym "EEG with generalised spikes" ; oboInOwl:id "HP:0012000" ; a owl:Class ; rdfs:label "EEG with generalized spikes" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0012001 obo:IAO_0000115 "EEG with repetitive generalized sharp transient waves of a duration less than 80 msec." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:41:07Z" ; oboInOwl:hasDbXref "UMLS:C4023088" ; oboInOwl:hasExactSynonym "EEG with generalised polyspikes" ; oboInOwl:id "HP:0012001" ; a owl:Class ; rdfs:label "EEG with generalized polyspikes" ; rdfs:subClassOf obo:HP_0011198 . obo:HP_0012002 obo:IAO_0000115 "Affective, mnemonic or composite perceptual auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:50:13Z" ; oboInOwl:hasDbXref "UMLS:C4023087" ; oboInOwl:hasExactSynonym "Experiential aura", "Experiential auras" ; oboInOwl:id "HP:0012002" ; a owl:Class ; rdfs:label "Experiential epileptic aura" ; rdfs:subClassOf obo:HP_0033346 . obo:HP_0012003 obo:IAO_0000115 "Affective auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:52:11Z" ; oboInOwl:hasDbXref "UMLS:C4023086" ; oboInOwl:hasExactSynonym "Affective aura", "Affective auras", "Emotional aura" ; oboInOwl:id "HP:0012003" ; a owl:Class ; rdfs:label "Affective epileptic aura" ; rdfs:subClassOf obo:HP_0033346 . obo:HP_0012004 obo:IAO_0000115 "A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:53:39Z" ; oboInOwl:hasAlternativeId "HP:0032697" ; oboInOwl:hasDbXref "UMLS:C4023085" ; oboInOwl:hasExactSynonym "Mnemonic aura", "Mnemonic auras" ; oboInOwl:id "HP:0012004" ; a owl:Class ; rdfs:comment "See the Glossary of Descriptive Terminology for Ictal Semiology at http://www.ilae.org." ; rdfs:label "Focal cognitive seizure with deja vu/jamais vu" ; rdfs:subClassOf obo:HP_0012002, obo:HP_0032680 . obo:HP_0012005 obo:IAO_0000115 "A subjective feeling that an experience which is occurring for the first time has been experienced before." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:54:16Z" ; oboInOwl:hasDbXref "MSH:D003690", "SNOMEDCT_US:313005", "UMLS:C0011194" ; oboInOwl:hasExactSynonym "Deja vu" ; oboInOwl:id "HP:0012005" ; a owl:Class ; rdfs:label "Deja vu aura" ; rdfs:subClassOf obo:HP_0012004 . obo:HP_0012006 obo:IAO_0000115 "A subjective feeling that an experience which has occurred before is being experienced for the first time." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:55:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:28249008", "UMLS:C0233803" ; oboInOwl:hasExactSynonym "Jamais vu" ; oboInOwl:id "HP:0012006" ; a owl:Class ; rdfs:label "Jamais vu aura" ; rdfs:subClassOf obo:HP_0012004 . obo:HP_0012007 obo:IAO_0000115 "A focal cognitive seizure characterized by hallucination as the initial semiological manifestation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:56:47Z" ; oboInOwl:hasAlternativeId "HP:0032703" ; oboInOwl:hasDbXref "UMLS:C4023084" ; oboInOwl:hasExactSynonym "Hallucinatory aura", "Hallucinatory auras" ; oboInOwl:id "HP:0012007" ; a owl:Class ; rdfs:comment "Hallucination is the creation of composite perceptions without the presence of external sensory stimuli, these may be visual (e.g. formed images), auditory (e.g. hearing voices) or involve other sensory modalities, without change in awareness. The sensory phenomena may be accompanied by associated emotion or interpretation e.g. a formed visual image may be accompanied by fear, or may be experienced as persecutory or with paranoia (i.e. with unjustified suspicion / mistrust). These features distinguish focal seizures with hallucinations from focal sensory seizures." ; rdfs:label "Focal cognitive seizure with hallucination" ; rdfs:subClassOf obo:HP_0032680, obo:HP_0033347 . obo:HP_0012008 obo:IAO_0000115 "A focal cognitive seizure characterized by an alteration of actual perception involving visual, auditory, somatosensory, olfactory, and/or gustatory phenomena as the initial semiological manifestation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:57:32Z" ; oboInOwl:hasAlternativeId "HP:0032695" ; oboInOwl:hasDbXref "UMLS:C4023083" ; oboInOwl:hasExactSynonym "Illusory aura", "Illusory auras" ; oboInOwl:id "HP:0012008" ; a owl:Class ; rdfs:label "Focal cognitive seizure with illusion" ; rdfs:subClassOf obo:HP_0032680, obo:HP_0033347 . obo:HP_0012009 obo:IAO_0000115 "EEG with focal sharp transient waves in the central region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4023082" ; oboInOwl:id "HP:0012009" ; a owl:Class ; rdfs:label "EEG with central focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033718 . obo:HP_0012010 obo:IAO_0000115 "EEG with focal sharp transient waves in the frontal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:59:21Z" ; oboInOwl:hasDbXref "UMLS:C4023081" ; oboInOwl:id "HP:0012010" ; a owl:Class ; rdfs:label "EEG with frontal focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033716 . obo:HP_0012011 obo:IAO_0000115 "EEG with focal sharp transient waves in the occipital region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T11:59:43Z" ; oboInOwl:hasDbXref "UMLS:C4023080" ; oboInOwl:id "HP:0012011" ; a owl:Class ; rdfs:label "EEG with occipital focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033720 . obo:HP_0012012 obo:IAO_0000115 "EEG with focal sharp transient waves in the parietal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:00:43Z" ; oboInOwl:hasDbXref "UMLS:C4023079" ; oboInOwl:id "HP:0012012" ; a owl:Class ; rdfs:label "EEG with parietal focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033719 . obo:HP_0012013 obo:IAO_0000115 "EEG with focal sharp transient waves in the temporal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:01:01Z" ; oboInOwl:hasDbXref "UMLS:C4023078" ; oboInOwl:id "HP:0012013" ; a owl:Class ; rdfs:label "EEG with temporal focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033717 . obo:HP_0012014 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec in the central region." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:01:29Z" ; oboInOwl:hasDbXref "UMLS:C4023077" ; oboInOwl:id "HP:0012014" ; a owl:Class ; rdfs:label "EEG with central focal spikes" ; rdfs:subClassOf obo:HP_0011193, obo:HP_0033718 . obo:HP_0012015 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec in the frontal region." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:02:12Z" ; oboInOwl:hasDbXref "UMLS:C4023076" ; oboInOwl:id "HP:0012015" ; a owl:Class ; rdfs:label "EEG with frontal focal spikes" ; rdfs:subClassOf obo:HP_0011193, obo:HP_0033716 . obo:HP_0012016 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec in the occipital region." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:02:28Z" ; oboInOwl:hasDbXref "UMLS:C4023075" ; oboInOwl:id "HP:0012016" ; a owl:Class ; rdfs:label "EEG with occipital focal spikes" ; rdfs:subClassOf obo:HP_0011193, obo:HP_0033720 . obo:HP_0012017 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec in the parietal region." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:02:43Z" ; oboInOwl:hasDbXref "UMLS:C4023074" ; oboInOwl:id "HP:0012017" ; a owl:Class ; rdfs:label "EEG with parietal focal spikes" ; rdfs:subClassOf obo:HP_0011193, obo:HP_0033719 . obo:HP_0012018 obo:IAO_0000115 "EEG with focal sharp transient waves of a duration less than 80 msec in the temporal region." ; dcterms:creator ; oboInOwl:creation_date "2012-07-20T12:02:59Z" ; oboInOwl:hasDbXref "UMLS:C4023073" ; oboInOwl:id "HP:0012018" ; a owl:Class ; rdfs:label "EEG with temporal focal spikes" ; rdfs:subClassOf obo:HP_0011193, obo:HP_0033717 . obo:HP_0012019 obo:IAO_0000115 "Complete dislocation of the lens of the eye." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:40:02Z" ; oboInOwl:hasDbXref "MSH:D007906", "UMLS:C0023309" ; oboInOwl:hasExactSynonym "Dislocated lens", "Dislocated lenses" ; oboInOwl:id "HP:0012019" ; a owl:Class ; rdfs:label "Lens luxation" ; rdfs:subClassOf obo:HP_0001083 . obo:HP_0012020 obo:IAO_0000115 "Aorta descends on right instead of on the left." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T09:25:32Z" ; oboInOwl:hasDbXref "Fyler:2720", "SNOMEDCT_US:111321007", "SNOMEDCT_US:244229003", "UMLS:C0035615" ; oboInOwl:hasExactSynonym "Right-sided aortic arch" ; oboInOwl:id "HP:0012020" ; a owl:Class ; rdfs:comment "The are several types of right aortic arch (RAA). RAA can recognized radiographically by leftward displacement of barium-filled esophagus or of an air-filled trachea. The aortic knob is absent from left side, and the para-aortic stripe returns to left side of spine just above diaphragm." ; rdfs:label "Right aortic arch" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0012021 obo:IAO_0000115 "Persistence of blood flow through the ductus venosus for longer than the normal time after birth." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:10:58Z" ; oboInOwl:hasDbXref "UMLS:C4023072" ; oboInOwl:id "HP:0012021" ; a owl:Class ; rdfs:comment "The ductus venosus is a bypass between the umbilical vein and the inferior vena cava in the fetus. The blood flow through this bypass decreases immediately after birth. Functional closure, which is followed by anatomic closure, is virtually complete within a few weeks of birth." ; rdfs:label "Persistent patent ductus venosus" ; rdfs:subClassOf obo:HP_0034190 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001507 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0061116 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012022 obo:IAO_0000115 "A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver)." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:16:40Z" ; oboInOwl:hasDbXref "MSH:C562830", "SNOMEDCT_US:253330006", "UMLS:C0344688" ; oboInOwl:id "HP:0012022" ; a owl:Class ; rdfs:label "Congenital portosystemic venous shunt" ; rdfs:subClassOf obo:HP_0034190 . obo:HP_0012023 obo:IAO_0000115 "Elevated concentration of galactose in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:31:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:71690006", "UMLS:C0268157" ; oboInOwl:hasExactSynonym "Increased urinary galactose level" ; oboInOwl:id "HP:0012023" ; a owl:Class ; rdfs:label "Galactosuria" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28260 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012024 obo:IAO_0000115 "Elevated concentration of galactose in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:35:58Z" ; oboInOwl:hasDbXref "MSH:D005693", "SNOMEDCT_US:190745006", "SNOMEDCT_US:190749000", "UMLS:C0016952", "UMLS:C4023071" ; oboInOwl:hasRelatedSynonym "Galactosemia" ; oboInOwl:id "HP:0012024" ; a owl:Class ; rdfs:comment "Hypergalactosemia is used here to mean the increased concentration of galactose in the blood. Note that the word galactosemia is occasionally used with the same meaning but more commonly denotes the disease entity called galactosemia caused by mutations in the galactose-1-phosphate uridyltransferase gene (MIM:230400)." ; rdfs:label "Hypergalactosemia" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28260 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012025 obo:IAO_0000115 "Deviation from the normal concentration of ornithine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:48:59Z" ; oboInOwl:hasDbXref "UMLS:C4023070" ; oboInOwl:id "HP:0012025" ; a owl:Class ; rdfs:comment "Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. Ornithine is a naturally occurring, non-proteinogenic amino acid found in meat, fish, dairy and eggs." ; rdfs:label "Abnormal circulating ornithine concentration" ; rdfs:subClassOf obo:HP_0033109 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006591 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012026 obo:IAO_0000115 "Increased concentration of ornithine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:49:54Z" ; oboInOwl:hasDbXref "MSH:D015799", "SNOMEDCT_US:276426004", "SNOMEDCT_US:33985005", "UMLS:C0599035" ; oboInOwl:hasExactSynonym "High blood ornithine levels" ; oboInOwl:id "HP:0012026" ; a owl:Class ; rdfs:label "Hyperornithinemia" ; rdfs:subClassOf obo:HP_0012025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012027 obo:IAO_0000115 "An abnormal accumulation of fluid and swelling in the tissues of the larynx." ; dcterms:creator ; oboInOwl:creation_date "2012-07-26T10:51:45Z" ; oboInOwl:hasDbXref "MSH:D007819", "SNOMEDCT_US:51599000", "UMLS:C0023052" ; oboInOwl:hasExactSynonym "Laryngeal oedema" ; oboInOwl:id "HP:0012027" ; a owl:Class ; rdfs:label "Laryngeal edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012028 obo:IAO_0000115 "A benign tumor of the liver of presumably epithelial origin." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:24:44Z" ; oboInOwl:hasDbXref "MPATH:353", "MSH:D018248", "SNOMEDCT_US:424263008", "SNOMEDCT_US:78058005", "UMLS:C0206669" ; oboInOwl:hasExactSynonym "Hepatic adenoma", "Liver cell adenoma" ; oboInOwl:id "HP:0012028" ; a owl:Class ; rdfs:label "Hepatocellular adenoma" ; rdfs:subClassOf obo:HP_0002896 . obo:HP_0012029 obo:IAO_0000115 "An abnormal concentration of a hormone in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:29:51Z" ; oboInOwl:hasDbXref "UMLS:C4023069" ; oboInOwl:hasExactSynonym "Abnormality of urine hormone level" ; oboInOwl:id "HP:0012029" ; a owl:Class ; rdfs:label "Abnormal urine hormone level" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_24621 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012030 obo:IAO_0000115 "Abnormally increased concentration of cortisol in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:30:44Z" ; oboInOwl:hasDbXref "UMLS:C4023068" ; oboInOwl:hasExactSynonym "High urine cortisol level" ; oboInOwl:id "HP:0012030" ; a owl:Class ; rdfs:label "Increased urinary cortisol level" ; rdfs:subClassOf obo:HP_0012029 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17650 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012031 dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:32:28Z" ; oboInOwl:hasDbXref "MPATH:415", "MSH:D018205", "SNOMEDCT_US:115227001", "SNOMEDCT_US:254827004", "SNOMEDCT_US:254831005", "UMLS:C0206631" ; oboInOwl:hasExactSynonym "Lipomatous tumour" ; oboInOwl:id "HP:0012031" ; a owl:Class ; rdfs:label "Lipomatous tumor" ; rdfs:subClassOf obo:HP_0200013 . obo:HP_0012032 obo:IAO_0000115 "Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:33:13Z" ; oboInOwl:hasDbXref "MEDDRA:10024612", "MPATH:417", "MSH:D008067", "SNOMEDCT_US:46720004", "SNOMEDCT_US:93163002", "UMLS:C0023798" ; oboInOwl:hasExactSynonym "Fatty lump", "Noncancerous fatty lump" ; oboInOwl:id "HP:0012032" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lipoma" ; rdfs:subClassOf obo:HP_0012031 . obo:HP_0012033 obo:IAO_0000115 "Presence of a lipoma in the region of the sacrum." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:37:57Z" ; oboInOwl:hasDbXref "UMLS:C4021835" ; oboInOwl:id "HP:0012033" ; a owl:Class ; rdfs:label "Sacral lipoma" ; rdfs:subClassOf obo:HP_0012032 . obo:HP_0012034 obo:IAO_0000115 "Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:40:25Z" ; oboInOwl:hasDbXref "MPATH:418", "MSH:D008080", "SNOMEDCT_US:254829001", "SNOMEDCT_US:49430005", "UMLS:C0023827" ; oboInOwl:id "HP:0012034" ; a owl:Class ; rdfs:label "Liposarcoma" ; rdfs:subClassOf obo:HP_0012031 . obo:HP_0012035 obo:IAO_0000115 "Multiple, localized or widespread, asymptomatic or inflammatory dermal cysts involving the pilosebaceous units. Lesions can appear anywhere on the body, but steatocystoma multiplex is more commonly involved with those areas of the skin with a high density of developed pilosebaceous units (e.g., the axilla, groin, neck, and proximal extremities)." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:45:14Z" ; oboInOwl:hasDbXref "MSH:D062685", "SNOMEDCT_US:109433009", "UMLS:C0259771" ; oboInOwl:id "HP:0012035" ; a owl:Class ; rdfs:comment "Steatocystoma multiplex can present with localized, generalized, facial, acral, or suppurative involvement." ; rdfs:label "Steatocystoma multiplex" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0012036 obo:IAO_0000115 "Wasting of the sternocleidomastoid muscle, the muscle in the anterior part of the neck that acts to flex and rotate the head." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:51:24Z" ; oboInOwl:hasDbXref "UMLS:C4023067" ; oboInOwl:id "HP:0012036" ; a owl:Class ; rdfs:label "Sternocleidomastoid amyotrophy" ; rdfs:subClassOf obo:HP_0003202 . obo:HP_0012037 obo:IAO_0000115 "Wasting of the pectoral muscles, i.e., of the pectoralis major and pectoralis minor." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T01:55:38Z" ; oboInOwl:hasDbXref "UMLS:C4023066" ; oboInOwl:hasExactSynonym "Wasting of pec muscles" ; oboInOwl:id "HP:0012037" ; a owl:Class ; rdfs:label "Pectoralis amyotrophy" ; rdfs:subClassOf obo:HP_0003202, obo:HP_0011957 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001495 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012038 obo:IAO_0000115 "Corneal guttata are droplet-like accumulations of non-banded collagen on the posterior surface of Descemet's membrane. The presence of focal thickenings of Descemet's membrane histologically named guttae. Cornea guttata can be easily diagnosed in vivo and ex vivo by means of specular microscopy as it gives dark areas where no endothelial cells are visible." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T02:06:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:373424008", "UMLS:C0271288" ; oboInOwl:hasExactSynonym "Corneal endothelial guttata", "Corneal guttae" ; oboInOwl:id "HP:0012038" ; a owl:Class ; rdfs:comment "Corneal guttata are often observed in elderly people and are known to be associated with Fuchs corneal endothelial dystrophy, and also with trauma, congenital glaucoma, and macular dystrophy." ; rdfs:label "Corneal guttata" ; rdfs:subClassOf obo:HP_0011490 . obo:HP_0012039 obo:IAO_0000115 "Presence of folds in the Descemet membrane, which is the basement membrane of the endothelial (inner) cell layer of the cornea. Descemet membrane folds are generally a manifestation of inflammation or edema of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T02:14:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:193821003", "UMLS:C0155116" ; oboInOwl:id "HP:0012039" ; a owl:Class ; rdfs:label "Descemet Membrane Folds" ; rdfs:subClassOf obo:HP_0011490 . obo:HP_0012040 obo:IAO_0000115 "Abnormal accumulation of fluid and swelling of the stroma of cornea." ; dcterms:creator ; oboInOwl:creation_date "2012-07-27T02:19:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:373430008", "UMLS:C0474444" ; oboInOwl:hasExactSynonym "Corneal stromal oedema" ; oboInOwl:id "HP:0012040" ; a owl:Class ; rdfs:label "Corneal stromal edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0011492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012041 dcterms:creator ; oboInOwl:creation_date "2012-07-30T06:50:19Z" ; oboInOwl:hasDbXref "UMLS:C0151640" ; oboInOwl:hasExactSynonym "Decreased fertility in males" ; oboInOwl:id "HP:0012041" ; a owl:Class ; rdfs:label "Decreased fertility in males" ; rdfs:subClassOf obo:HP_0000144 . obo:HP_0012042 obo:IAO_0000115 "A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T11:22:04Z" ; oboInOwl:hasDbXref "MSH:D055963", "SNOMEDCT_US:407674008", "UMLS:C1319853" ; oboInOwl:hasExactSynonym "Aspirin-induced asthma" ; oboInOwl:id "HP:0012042" ; a owl:Class ; rdfs:label "Aspirin-induced asthma" ; rdfs:subClassOf obo:HP_0002099 . obo:HP_0012043 obo:IAO_0000115 "Rhythmic, involuntary sinusoidal oscillations of one or both eyes. The waveform of pendular nystagmus may occur in any direction." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:04:00Z" ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:35743001", "UMLS:C0271388", "UMLS:C4020734" ; oboInOwl:hasRelatedSynonym "Nystagmus, continuous pendular", "Nystagmus, pendular" ; oboInOwl:id "HP:0012043" ; a owl:Class ; rdfs:label "Pendular nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0012044 obo:IAO_0000115 "Seesaw nystagmus is a type of pendular nystagmus where a half cycle consists of the elevation and intorsion of one eye, concurrently with the depression and extortion of the fellow eye. In the other half cycle, there is an inversion of the ocular movements." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:06:36Z" ; oboInOwl:hasDbXref "MSH:D009759", "SNOMEDCT_US:95782001", "UMLS:C0344243" ; oboInOwl:id "HP:0012044" ; a owl:Class ; rdfs:comment "Seesaw nystagmus can be a manifestation of lesions of the optic chiasma." ; rdfs:label "Seesaw nystagmus" ; rdfs:subClassOf obo:HP_0012043 . obo:HP_0012045 obo:IAO_0000115 "Presence of multiple yellowish-white lesions of various size and configuration on the retina not related to vascular lesions." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:17:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:247138002", "UMLS:C0423414" ; oboInOwl:id "HP:0012045" ; a owl:Class ; rdfs:label "Retinal flecks" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0012046 obo:IAO_0000115 "Inability to elicit tendon reflexes in the upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:24:31Z" ; oboInOwl:hasDbXref "UMLS:C2674177" ; oboInOwl:id "HP:0012046" ; a owl:Class ; rdfs:label "Areflexia of upper limbs" ; rdfs:subClassOf obo:HP_0001284, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012047 obo:IAO_0000115 "A visual defect characterized by the inability to see as clearly in bright light as in dim light. The word hemeralopia literally means day blindness." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:26:28Z" ; oboInOwl:hasDbXref "MSH:D014786", "SNOMEDCT_US:399323001", "UMLS:C0018975" ; oboInOwl:hasExactSynonym "Day blindness" ; oboInOwl:id "HP:0012047" ; a owl:Class ; rdfs:label "Hemeralopia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0012048 obo:IAO_0000115 "A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:29:50Z" ; oboInOwl:hasAlternativeId "HP:0001494" ; oboInOwl:hasDbXref "UMLS:C2242577" ; oboInOwl:hasExactSynonym "Cranial dystonia" ; oboInOwl:id "HP:0012048" ; a owl:Class ; rdfs:label "Oromandibular dystonia" ; rdfs:subClassOf obo:HP_0012179 . obo:HP_0012049 obo:IAO_0000115 "A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:34:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:3331000119108", "UMLS:C1963946" ; oboInOwl:hasExactSynonym "Spasmodic dysphonia" ; oboInOwl:id "HP:0012049" ; a owl:Class ; rdfs:label "Laryngeal dystonia" ; rdfs:subClassOf obo:HP_0001618, obo:HP_0004373 . obo:HP_0012050 obo:IAO_0000115 "An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:53:48Z" ; oboInOwl:hasDbXref "MSH:D004487", "SNOMEDCT_US:16740003", "SNOMEDCT_US:442433009", "UMLS:C0151603" ; oboInOwl:hasExactSynonym "Extreme generalised oedema", "Extreme generalized edema" ; oboInOwl:id "HP:0012050" ; a owl:Class ; rdfs:label "Anasarca" ; rdfs:subClassOf obo:HP_0007430 . obo:HP_0012051 obo:IAO_0000115 "Hypoglycermia following a meal (or more generally, after intake of glucose)." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T12:57:57Z" ; oboInOwl:hasDbXref "MSH:D007003", "SNOMEDCT_US:237638000", "SNOMEDCT_US:317006", "UMLS:C0271710" ; oboInOwl:hasExactSynonym "Low blood sugar after a meal", "Postprandial hypoglycemia" ; oboInOwl:id "HP:0012051" ; a owl:Class ; rdfs:comment "Reactive hypoglycemia may be the result of an exaggerated insulin response." ; rdfs:label "Reactive hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0012052 obo:IAO_0000115 "A reduced concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T01:02:39Z" ; oboInOwl:hasDbXref "UMLS:C4023065" ; oboInOwl:hasExactSynonym "Low serum 1,25-dihydroxycholecalciferol", "Low serum 1,25-dihydroxyvitamin D3" ; oboInOwl:id "HP:0012052" ; a owl:Class ; rdfs:label "Low serum calcitriol" ; rdfs:subClassOf obo:HP_0100511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17823 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012053 obo:IAO_0000115 "A reduced concentration of calcifediol in the blood. Calcifediol is also known as calcidiol, 25-hydroxycholecalciferol and 25-Hydroxyvitamin D3." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T01:04:42Z" ; oboInOwl:hasDbXref "UMLS:C4023064" ; oboInOwl:hasExactSynonym "Decreased 25-hydroxyvitamin D3", "Low serum 25-hydroxycholecalciferol", "Low serum calcidiol", "Low serum calcifediol" ; oboInOwl:id "HP:0012053" ; a owl:Class ; rdfs:label "Decreased circulating calcifediol concentration" ; rdfs:subClassOf obo:HP_0100511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17933 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012054 obo:IAO_0000115 "Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented)." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T01:59:00Z" ; oboInOwl:hasDbXref "NCIT:C3224", "SNOMEDCT_US:255021005", "UMLS:C0346388" ; oboInOwl:id "HP:0012054" ; a owl:Class ; rdfs:label "Choroidal melanoma" ; rdfs:subClassOf obo:HP_0007716 . obo:HP_0012055 obo:IAO_0000115 "Malignant tumor of melanocytes of the ciliary body." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:01:02Z" ; oboInOwl:hasDbXref "NCIT:C3224", "SNOMEDCT_US:255015006", "UMLS:C0346379" ; oboInOwl:id "HP:0012055" ; a owl:Class ; rdfs:label "Ciliary body melanoma" ; rdfs:subClassOf obo:HP_0007716, obo:HP_0012776 . obo:HP_0012056 obo:IAO_0000115 "The presence of a melanoma of the skin." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:04:21Z" ; oboInOwl:hasDbXref "MSH:D008545", "NCIT:C3224", "SNOMEDCT_US:2092003", "SNOMEDCT_US:372244006", "UMLS:C0025202" ; oboInOwl:id "HP:0012056" ; a owl:Class ; rdfs:comment "The phenotypic presentation of melanomas is often described using the ABCDE mnemomic: A) Asymmetry; B) Borders of the lesion are irregular; C) Color changes from one area of the lesion to another, with shades of tan, brown, or black, and sometimes white, red, or blue; D) Diameter of the lesionis usually larger than 6 mm; E) Evolution of the appearance of the lesion with time. These rules do not, however, apply to every melanoma." ; rdfs:label "Cutaneous melanoma" ; rdfs:subClassOf obo:HP_0002861, obo:HP_0008069 . obo:HP_0012057 obo:IAO_0000115 "A type of melanoma that is flat and irregular in shape and color, with different shades of black and brown." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:07:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:254730000", "SNOMEDCT_US:55320002", "UMLS:C0334438" ; oboInOwl:id "HP:0012057" ; a owl:Class ; rdfs:label "Superficial spreading melanoma" ; rdfs:subClassOf obo:HP_0012056 . obo:HP_0012058 obo:IAO_0000115 "A type of melanoma that starts as a raised area that is usually dark blackish-blue or bluish-red but may not have any color." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:08:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:2142002", "SNOMEDCT_US:254731001", "UMLS:C0334424" ; oboInOwl:id "HP:0012058" ; a owl:Class ; rdfs:label "Nodular melanoma" ; rdfs:subClassOf obo:HP_0012056 . obo:HP_0012059 obo:IAO_0000115 "A subtype of melanoma in situ that typically develops on sun-damaged skin. The lesion is typically a large, irregularly pigmented macule that has developed from an ordinary lentigo (a small pigmented spot on the skin with a clearly-defined edge). Change to a malignant lentigo typically takes place over 20 years or more, and many patients accept the change as a consequence of aging." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:16:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:302837001", "SNOMEDCT_US:44474009", "UMLS:C2739810" ; oboInOwl:id "HP:0012059" ; a owl:Class ; rdfs:label "Lentigo maligna melanoma" ; rdfs:subClassOf obo:HP_0012056 . obo:HP_0012060 obo:IAO_0000115 "A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discoloured skin and usually displays a size above 6 mm and often several centimetres or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed." ; dcterms:creator ; oboInOwl:creation_date "2012-08-01T02:17:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:16974005", "SNOMEDCT_US:254732008", "UMLS:C0346037" ; oboInOwl:id "HP:0012060" ; a owl:Class ; rdfs:label "Acral lentiginous melanoma" ; rdfs:subClassOf obo:HP_0012056 . obo:HP_0012061 obo:IAO_0000115 "Excretion of oligosaccharides conjugated to sialic acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T02:14:44Z" ; oboInOwl:hasDbXref "UMLS:C2673302" ; oboInOwl:hasExactSynonym "Increased urinary sialyloligosaccharides" ; oboInOwl:id "HP:0012061" ; a owl:Class ; rdfs:label "Urinary excretion of sialylated oligosaccharides" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0012062 obo:IAO_0000115 "A fluid filled cavity that develops with a bone." ; dcterms:creator ; oboInOwl:creation_date "2012-08-03T02:35:39Z" ; oboInOwl:hasAlternativeId "HP:0100696" ; oboInOwl:hasDbXref "MSH:D001845", "SNOMEDCT_US:112643007", "SNOMEDCT_US:203465002", "SNOMEDCT_US:203467005", "SNOMEDCT_US:66954000", "UMLS:C0005937" ; oboInOwl:hasExactSynonym "Bone cyst", "Bone cysts" ; oboInOwl:id "HP:0012062" ; a owl:Class ; rdfs:comment "Many bone cysts are asymptomatic. However, larger cysts can make the bone more susceptible to fracture." ; rdfs:label "Bone cyst" ; rdfs:subClassOf obo:HP_0003330 . obo:HP_0012063 obo:IAO_0000115 "Radiographic features include a dilated, radiolucent lesion typically located eccentrically within the metaphyseal portion of the bone, with fluid levels visible on magnetic resonance imaging." ; dcterms:creator ; oboInOwl:creation_date "2012-08-03T02:35:52Z" ; oboInOwl:hasDbXref "MSH:D017824", "SNOMEDCT_US:203468000", "SNOMEDCT_US:76000001", "UMLS:C0152244" ; oboInOwl:id "HP:0012063" ; a owl:Class ; rdfs:label "Aneurysmal bone cyst" ; rdfs:subClassOf obo:HP_0012062 . obo:HP_0012064 obo:IAO_0000115 "A benign fluid filled simple cyst of bone filled with serous fluid." ; dcterms:creator ; oboInOwl:creation_date "2012-08-03T02:42:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:112643007", "SNOMEDCT_US:203467005", "UMLS:C4082185" ; oboInOwl:id "HP:0012064" ; a owl:Class ; rdfs:label "Unicameral bone cyst" ; rdfs:subClassOf obo:HP_0012062 . obo:HP_0012065 obo:IAO_0000115 "Presence of multiple cystic changes in multiple areas or multiple bones." ; dcterms:creator ; oboInOwl:creation_date "2012-08-03T02:45:09Z" ; oboInOwl:hasDbXref "UMLS:C4023063" ; oboInOwl:hasExactSynonym "Multiple bony cystic lesions" ; oboInOwl:id "HP:0012065" ; a owl:Class ; rdfs:label "Multiple bony cystic lesions" ; rdfs:subClassOf obo:HP_0012062 . obo:HP_0012066 obo:IAO_0000115 "Increased concentration of disaccharide in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T02:54:28Z" ; oboInOwl:hasDbXref "UMLS:C4023062" ; oboInOwl:id "HP:0012066" ; a owl:Class ; rdfs:comment "Excess amount of disaccharides such as mannosyl-N-acetylglucosamine excreted in the urine." ; rdfs:label "Increased urinary disaccharide excretion" ; rdfs:subClassOf obo:HP_0010471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36233 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012067 obo:IAO_0000115 "Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T03:03:03Z" ; oboInOwl:hasDbXref "UMLS:C4023061" ; oboInOwl:hasExactSynonym "High urine glycopeptide levels" ; oboInOwl:id "HP:0012067" ; a owl:Class ; rdfs:comment "This feature is often the result of a defect in glycosidase activate. Glycosidases catalyze the release of sugar moieties." ; rdfs:label "Glycopeptiduria" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24396 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012068 obo:IAO_0000115 "Excretion of excess amounts of aspartylglucosamine in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T03:15:37Z" ; oboInOwl:hasDbXref "MSH:D054880", "SNOMEDCT_US:54954004", "UMLS:C0268225" ; oboInOwl:hasExactSynonym "High urine aspartylglucosamine levels" ; oboInOwl:id "HP:0012068" ; a owl:Class ; rdfs:label "Aspartylglucosaminuria" ; rdfs:subClassOf obo:HP_0012067 . obo:HP_0012069 obo:IAO_0000115 "An increased concentration of keratan sulfate in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T03:20:15Z" ; oboInOwl:hasDbXref "UMLS:C4023060" ; oboInOwl:hasExactSynonym "Keratan sulphate excretion in urine" ; oboInOwl:id "HP:0012069" ; a owl:Class ; rdfs:comment "Keratan sulfate is a a glycosaminoglycan." ; rdfs:label "Keratan sulfate excretion in urine" ; rdfs:subClassOf obo:HP_0008155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_60924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012070 obo:IAO_0000115 "An increased concentration of chondroitin sulfate (CHEBI:37397) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-04T03:22:36Z" ; oboInOwl:hasDbXref "UMLS:C4023059" ; oboInOwl:hasExactSynonym "Chondroitin sulphate excretion in urine" ; oboInOwl:id "HP:0012070" ; a owl:Class ; rdfs:comment "Chondroitin sulfate refers to a class of 10-60 kDa glycosaminoglycan sulfates, which are widely distributed in cartilage." ; rdfs:label "Chondroitin sulfate excretion in urine" ; rdfs:subClassOf obo:HP_0008155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_37397 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012071 obo:IAO_0000115 "Any deviation from the normal concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T09:03:41Z" ; oboInOwl:hasDbXref "UMLS:C4020733", "UMLS:C4023058" ; oboInOwl:hasExactSynonym "Abnormal circulating esterified carnitine concentration" ; oboInOwl:hasRelatedSynonym "Abnormal acetylcarnitine profile" ; oboInOwl:id "HP:0012071" ; a owl:Class ; rdfs:comment "Carnitine fundergoes reversible esterification of its 3-hydroxyl group producing acylcarnitine, which can enter the mitochondria with the assistance of specific translocases." ; rdfs:label "Abnormal circulating acetylcarnitine concentration" ; rdfs:subClassOf obo:HP_0010967 . obo:HP_0012072 obo:IAO_0000115 "Excretion of urine with an acid pH, i.e., having an increased hydrogen ion concentration." ; oboInOwl:hasDbXref "SNOMEDCT_US:21806007", "UMLS:C0278026" ; oboInOwl:hasExactSynonym "Acidic urine" ; oboInOwl:id "HP:0012072" ; a owl:Class ; rdfs:label "Aciduria" ; rdfs:subClassOf obo:HP_0032943 . obo:HP_0012073 obo:IAO_0000115 "An abnormal distribution of N-acylglycines in the urine. There are numerous different N-acylglycines, and this term refers to pathological alterations in their level or distribution." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T09:46:03Z" ; oboInOwl:hasDbXref "UMLS:C4023057" ; oboInOwl:id "HP:0012073" ; a owl:Class ; rdfs:comment "N-acylglycines result from glycine conjugation with exogenous compounds to enhance their excretion in urine. Glycine conjugation is also an effective detoxification system for preventing accumulation of acyl-CoA esters in several inherited metabolic disorders." ; rdfs:label "Abnormal urinary acylglycine profile" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16180 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012074 obo:IAO_0000115 "An abnormality of the pupillary light reaction characterized by a marked slowing of the light reaction of usually just one pupil. The pupil tends to be relatively dilated, and there is reduced accommodation." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T09:58:20Z" ; oboInOwl:hasDbXref "MSH:D015845", "SNOMEDCT_US:24225004", "UMLS:C0040416" ; oboInOwl:hasExactSynonym "Adie pupil", "Adie's tonic pupil" ; oboInOwl:id "HP:0012074" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Tonic pupil" ; rdfs:subClassOf obo:HP_0007686 . obo:HP_0012075 obo:IAO_0000115 "An abnormality of mental functioning affecting the personality and behavioural tendencies of an individual and characterized by a rigid and unhealthy pattern of thinking and behavior. The definition of a personal disorder implies that the abnormality is not the result of damage or insult to the brain or from another psychiatric disorder." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T02:20:27Z" ; oboInOwl:hasDbXref "ICD-10:F60", "MSH:D010554", "SNOMEDCT_US:33449004", "UMLS:C0031212" ; oboInOwl:id "HP:0012075" ; a owl:Class ; rdfs:comment "A Personality disorder is generally associated with significant problems and limitations in relationships, social encounters, work and school. It is usually manifest since childhood or adolescence and continues throughout adulthood." ; rdfs:label "Personality disorder" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0012076 obo:IAO_0000115 "A personality disorder characterized by impulsive behavior and unpredictable and capricious mood. Affected individuals show a liability to outbursts of emotion and an incapacity to control the behavioural explosions." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T02:26:02Z" ; oboInOwl:hasDbXref "ICD-10:F60.3", "MSH:D001883", "SNOMEDCT_US:20010003", "UMLS:C0006012" ; oboInOwl:hasExactSynonym "BPD" ; oboInOwl:id "HP:0012076" ; a owl:Class ; rdfs:label "Borderline personality disorder" ; rdfs:subClassOf obo:HP_0012075 . obo:HP_0012077 obo:IAO_0000115 "A personality disorder characterized by shallow and labile affectivity, self-dramatization, theatricality, exaggerated expression of emotions, suggestibility, egocentricity, self-indulgence, lack of consideration for others, easily hurt feelings, and continuous seeking for appreciation, excitement and attention." ; dcterms:creator ; oboInOwl:creation_date "2012-08-11T02:38:39Z" ; oboInOwl:hasDbXref "ICD-10:F60.4", "MSH:D006677", "SNOMEDCT_US:55341008", "UMLS:C0019681" ; oboInOwl:id "HP:0012077" ; a owl:Class ; rdfs:label "Histrionic personality disorder" ; rdfs:subClassOf obo:HP_0012075 . obo:HP_0012078 obo:IAO_0000115 "Blockade of impulses at a focal site along the course of a motor axon." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T04:34:49Z" ; oboInOwl:hasDbXref "UMLS:C4023056" ; oboInOwl:id "HP:0012078" ; a owl:Class ; rdfs:label "Motor conduction block" ; rdfs:subClassOf obo:HP_0000762, obo:HP_0040131 . obo:HP_0012079 obo:IAO_0000115 "Any anomaly of the conduction of motor nerve impulses in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T04:41:05Z" ; oboInOwl:hasDbXref "UMLS:C4023055" ; oboInOwl:id "HP:0012079" ; a owl:Class ; rdfs:comment "Nerve conduction velocity in the central motor pathways of the brain and spinal cord can be studied by methods including transcutaneous electrical stimulation of the cortex, cervical cord, thoracic cord and conus medullaris and determination of motor latencies to various muscles. This measure is thought to represent conduction in large diameter fibres in the corticospinal tracts." ; rdfs:label "Abnormality of central motor conduction" ; rdfs:subClassOf obo:HP_0011442 . obo:HP_0012080 obo:IAO_0000115 "Atrophy of the cerebellum affecting primarily the granular cell layer." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T05:23:55Z" ; oboInOwl:hasDbXref "UMLS:C4023054" ; oboInOwl:id "HP:0012080" ; a owl:Class ; rdfs:label "Cerebellar granular layer atrophy" ; rdfs:subClassOf obo:HP_0001272 . obo:HP_0012081 obo:IAO_0000115 "An abnormally increased size of the cerebellum compared to other brain structures." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T05:29:26Z" ; oboInOwl:hasDbXref "UMLS:C3278024" ; oboInOwl:id "HP:0012081" ; a owl:Class ; rdfs:label "Enlarged cerebellum" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012082 obo:IAO_0000115 "Atrophy of the cerebellum affecting primarily the Purkinje cell layer." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T05:31:43Z" ; oboInOwl:hasDbXref "UMLS:C4023053" ; oboInOwl:id "HP:0012082" ; a owl:Class ; rdfs:label "Cerebellar Purkinje layer atrophy" ; rdfs:subClassOf obo:HP_0001272 . obo:HP_0012083 obo:IAO_0000115 "Nuclear or cytoplasmic aggregates that show positive staining with antibodies against ubiquitin within cells of the brain." ; dcterms:creator ; oboInOwl:creation_date "2012-08-18T05:34:56Z" ; oboInOwl:hasDbXref "UMLS:C4023052" ; oboInOwl:id "HP:0012083" ; a owl:Class ; rdfs:label "Ubiquitin-positive cerebral inclusion bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0012084 obo:IAO_0000115 "Any abnormality of the size of the skeletal muscle cell." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T03:19:54Z" ; oboInOwl:hasDbXref "UMLS:C4023051" ; oboInOwl:hasExactSynonym "Abnormality of skeletal muscle fibre size" ; oboInOwl:id "HP:0012084" ; a owl:Class ; rdfs:label "Abnormality of skeletal muscle fiber size" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0008002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012085 obo:IAO_0000115 "The presence of 10 or more white cells per cubic millimeter in a urine specimen, 3 or more white cells per high-power field of unspun urine, a positive result on Gram staining of an unspun urine specimen, or a urinary dipstick test that is positive for leukocyte esterase." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:10:26Z" ; oboInOwl:hasDbXref "MSH:D011776", "SNOMEDCT_US:275765006", "SNOMEDCT_US:4800001", "UMLS:C0034359" ; oboInOwl:hasExactSynonym "High urine neutrophil count" ; oboInOwl:hasRelatedSynonym "Leukocyturia" ; oboInOwl:id "HP:0012085" ; a owl:Class ; rdfs:label "Pyuria" ; rdfs:subClassOf obo:HP_0012614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012086 obo:IAO_0000115 "An abnormal color of the urine, that is, the color of the urine appears different from the usual straw-yellow color." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:12:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:102867009", "SNOMEDCT_US:167239007", "UMLS:C0522153" ; oboInOwl:hasExactSynonym "Abnormal urinary color", "Abnormal urinary colour", "Abnormal urine color", "Abnormal urine colour" ; oboInOwl:id "HP:0012086" ; a owl:Class ; rdfs:label "Abnormal urinary color" ; rdfs:subClassOf obo:HP_0033072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012087 obo:IAO_0000115 "An anomaly in the surface contour of mitochondria." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T11:02:39Z" ; oboInOwl:hasDbXref "UMLS:C4023050" ; oboInOwl:id "HP:0012087" ; a owl:Class ; rdfs:label "Abnormal mitochondrial shape" ; rdfs:subClassOf obo:HP_0008322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012088 obo:IAO_0000115 "A deviation from the normal odor of the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:13:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:8769003", "UMLS:C0278045" ; oboInOwl:hasExactSynonym "Abnormal urinary odor", "Abnormal urinary odour", "Abnormal urine smell" ; oboInOwl:id "HP:0012088" ; a owl:Class ; rdfs:comment "Urine does not usually have a strong smell, but the odor may be altered by a number of factors including some diseases. Foul-smelling urine may be due to bacteria that have caused a urinary tract infection. Sweet-smelling urine may be a sign of uncontrolled diabetes or more rarely a disease of metabolism. Liver disease and certain metabolic disorders may cause musty-smelling urine." ; rdfs:label "Abnormal urinary odor" ; rdfs:subClassOf obo:HP_0033072 . obo:HP_0012089 obo:IAO_0000115 "Arterial inflammation." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:15:19Z" ; oboInOwl:hasDbXref "MSH:D001167", "SNOMEDCT_US:52089001", "UMLS:C0003860" ; oboInOwl:hasExactSynonym "Inflammation of artery" ; oboInOwl:id "HP:0012089" ; a owl:Class ; rdfs:label "Arteritis" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0012090 dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:16:38Z" ; oboInOwl:hasDbXref "UMLS:C4023049" ; oboInOwl:hasExactSynonym "Abnormality of pancreas morphology", "Abnormally shaped pancreas" ; oboInOwl:id "HP:0012090" ; a owl:Class ; rdfs:label "Abnormal pancreas morphology" ; rdfs:subClassOf obo:HP_0001732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012091 obo:IAO_0000115 "An anomaly of the function of the pancreas." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:17:10Z" ; oboInOwl:hasDbXref "UMLS:C4023048" ; oboInOwl:id "HP:0012091" ; a owl:Class ; rdfs:label "Abnormality of pancreas physiology" ; rdfs:subClassOf obo:HP_0001732 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012092 obo:IAO_0000115 "A functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:17:46Z" ; oboInOwl:hasDbXref "UMLS:C4021103" ; oboInOwl:hasExactSynonym "Abnormal exocrine pancreatic function" ; oboInOwl:id "HP:0012092" ; a owl:Class ; rdfs:label "Abnormality of exocrine pancreas physiology" ; rdfs:subClassOf obo:HP_0012091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012093 obo:IAO_0000115 "A function abnormality of the endocrine pancreas." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:18:18Z" ; oboInOwl:hasDbXref "UMLS:C4023047" ; oboInOwl:id "HP:0012093" ; a owl:Class ; rdfs:label "Abnormality of endocrine pancreas physiology" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0012091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012094 obo:IAO_0000115 "A deviation from the normal size of the pancreas." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:19:08Z" ; oboInOwl:hasDbXref "UMLS:C4023046" ; oboInOwl:hasExactSynonym "Abnormal pancreas size" ; oboInOwl:id "HP:0012094" ; a owl:Class ; rdfs:label "Abnormal pancreas size" ; rdfs:subClassOf obo:HP_0012090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012095 obo:IAO_0000115 "Dislocation of many joints." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:19:52Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:287096003", "SNOMEDCT_US:34277002", "UMLS:C0332792" ; oboInOwl:hasRelatedSynonym "Multiple joint dislocations" ; oboInOwl:id "HP:0012095" ; a owl:Class ; rdfs:label "Multiple joint dislocation" ; rdfs:subClassOf obo:HP_0001373 . obo:HP_0012096 obo:IAO_0000115 "A congenital inclusion cysts that arises from ectodermal cells that normally form skin cells being left behind in the nervous system during development." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:21:24Z" ; oboInOwl:hasDbXref "UMLS:C4023045" ; oboInOwl:id "HP:0012096" ; a owl:Class ; rdfs:comment "See Figure 8 in PMID:16714456. Epidermoid cysts arise from ectodermal inclusion during neural tube closure in the 3rd-5th week of embryogenesis. The microscopic cyst lining consists of stratified squamous epithelium supported by an outer layer of collagenous connective tissue. Cystic contents usually include debris, keratin, water, and cholesterol laid down in a lamellar fashion. Epidermoid cysts do not contain dermal appendages." ; rdfs:label "Intracranial epidermoid cyst" ; rdfs:subClassOf obo:HP_0010576 . obo:HP_0012097 obo:IAO_0000115 "A congenital inclusion cysts that arises from the inclusion of ectodermally committed cells at the time of neural tube closure (3rd-5th week of embryogenesis). The capsule of dermoid cysts consists of simple epithelium supported by collagen. In thicker parts, the lining is supplemented with dermis containing hair follicles, sebaceous glands, and apocrine glands." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:22:25Z" ; oboInOwl:hasDbXref "UMLS:C4023044" ; oboInOwl:id "HP:0012097" ; a owl:Class ; rdfs:comment "See Figure 9 in PMID:16714456. These cysts increase in size by means of glandular secretion and epithelial desquamation. Growth can lead to rupture of the cyst contents, causing a chemical meningitis that may lead to vasospasm, infarction, and even death." ; rdfs:label "Intracranial dermoid cyst" ; rdfs:subClassOf obo:HP_0010576 . obo:HP_0012098 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin on the back of the feet." ; dcterms:creator ; oboInOwl:creation_date "2012-08-20T09:33:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:445124008", "UMLS:C2919341" ; oboInOwl:hasExactSynonym "Edema of dorsum of feet", "Oedema of dorsum of feet", "Oedema of the dorsum of feet" ; oboInOwl:id "HP:0012098" ; a owl:Class ; rdfs:label "Edema of the dorsum of feet" ; rdfs:subClassOf obo:HP_0010741 . obo:HP_0012099 obo:IAO_0000115 "An abnormal catecholamine concentration in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-08-22T08:20:01Z" ; oboInOwl:hasDbXref "UMLS:C4021102" ; oboInOwl:hasExactSynonym "Catecholamine levels abnormal" ; oboInOwl:id "HP:0012099" ; a owl:Class ; rdfs:label "Abnormality of circulating catecholamine level" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012100 obo:IAO_0000115 "An abnormal concentration of creatinine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-08-22T08:40:14Z" ; oboInOwl:hasDbXref "UMLS:C4021101" ; oboInOwl:hasExactSynonym "Abnormal blood creatinine level", "Abnormal circulating creatinine level", "Creatinine levels abnormal" ; oboInOwl:id "HP:0012100" ; a owl:Class ; rdfs:label "Abnormal circulating creatinine concentration" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012101 obo:IAO_0000115 "An abnormally reduced amount of creatinine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-08-22T08:42:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:166715006", "UMLS:C0428282" ; oboInOwl:hasExactSynonym "Decreased serum creatinine", "Low blood creatinine level", "Reduced creatinine levels" ; oboInOwl:id "HP:0012101" ; a owl:Class ; rdfs:label "Decreased serum creatinine" ; rdfs:subClassOf obo:HP_0012100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16737 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012102 obo:IAO_0000115 "A deviation from the normal number of mitochondria per cell." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T11:03:33Z" ; oboInOwl:hasDbXref "UMLS:C4023043" ; oboInOwl:id "HP:0012102" ; a owl:Class ; rdfs:label "Abnormal mitochondrial number" ; rdfs:subClassOf obo:HP_0008322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012103 obo:IAO_0000115 "An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T11:05:06Z" ; oboInOwl:hasDbXref "UMLS:C4020732", "UMLS:C4023042" ; oboInOwl:hasRelatedSynonym "Mitochondrial abnormalities" ; oboInOwl:id "HP:0012103" ; a owl:Class ; rdfs:label "Abnormality of the mitochondrion" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012104 obo:IAO_0000115 "Atrophy of the parietal cortex." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T02:50:05Z" ; oboInOwl:hasDbXref "UMLS:C4023041" ; oboInOwl:id "HP:0012104" ; a owl:Class ; rdfs:label "Parietal cortical atrophy" ; rdfs:subClassOf obo:HP_0002120 . obo:HP_0012105 obo:IAO_0000115 "Atrophy of the occipital cortex." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T02:50:53Z" ; oboInOwl:hasDbXref "UMLS:C4023040" ; oboInOwl:id "HP:0012105" ; a owl:Class ; rdfs:label "Occipital cortical atrophy" ; rdfs:subClassOf obo:HP_0002120 . obo:HP_0012106 obo:IAO_0000115 "Disproportionate shortening of the proximal segment of the leg (i.e. the femur)." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T03:53:33Z" ; oboInOwl:hasDbXref "UMLS:C4023039" ; oboInOwl:id "HP:0012106" ; a owl:Class ; rdfs:label "Rhizomelic leg shortening" ; rdfs:subClassOf obo:HP_0008905 . obo:HP_0012107 obo:IAO_0000115 "Increased width of the cross sectional diameter of the fibula." ; dcterms:creator ; oboInOwl:creation_date "2012-09-08T04:03:50Z" ; oboInOwl:hasAlternativeId "HP:0200082" ; oboInOwl:hasDbXref "UMLS:C4021100" ; oboInOwl:hasExactSynonym "Thick fibula", "Thick fibulae", "Wide calf bone", "Wide fibula" ; oboInOwl:id "HP:0012107" ; a owl:Class ; rdfs:label "Increased fibular diameter" ; rdfs:subClassOf obo:HP_0002991, obo:HP_0005622 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012108 obo:IAO_0000115 "A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure," ; dcterms:creator ; oboInOwl:creation_date "2012-09-10T05:17:24Z" ; oboInOwl:hasDbXref "MSH:C562750", "SNOMEDCT_US:77075001", "UMLS:C0339573" ; oboInOwl:hasRelatedSynonym "Primary open angle glaucoma" ; oboInOwl:id "HP:0012108" ; a owl:Class ; rdfs:comment "Evidence of optic nerve damage can include s optic disc abnormalities (Vertical cup:disc ratio over the 97. 5th percentile in the normal population), visual field defects. The role of increased intraocular pressure (IOP) in glaucoma is debated, but an IOP exceeding the 99. 5th percentile of the normal population may be considered to support the diagnosis." ; rdfs:label "Open angle glaucoma" ; rdfs:subClassOf obo:HP_0000501 . obo:HP_0012109 obo:IAO_0000115 "A type of glaucomatous optic neuropathy in an eye that has evidence of angle closure (i.e. significant iridotrabecular contact)." ; dcterms:creator ; oboInOwl:creation_date "2012-09-10T05:22:48Z" ; oboInOwl:hasAlternativeId "HP:0032119" ; oboInOwl:hasDbXref "SNOMEDCT_US:392288006", "UMLS:C0017606" ; oboInOwl:hasExactSynonym "Closed-angle glaucoma", "Narrow angle glaucoma" ; oboInOwl:hasRelatedSynonym "Primary angle closure glaucoma" ; oboInOwl:id "HP:0012109" ; a owl:Class ; rdfs:comment "Evidence of optic nerve damage can include s optic disc abnormalities (Vertical cup:disc ratio over the 97. 5th percentile in the normal population), visual field defects. The role of increased intraocular pressure (IOP) in glaucoma is debated, but an IOP exceeding the 99. 5th percentile of the normal population may be considered to support the diagnosis." ; rdfs:label "Angle closure glaucoma" ; rdfs:subClassOf obo:HP_0000501 . obo:HP_0012110 obo:IAO_0000115 "Underdevelopment of the pons." ; dcterms:creator ; oboInOwl:creation_date "2012-09-10T05:35:36Z" ; oboInOwl:hasDbXref "UMLS:C1848529" ; oboInOwl:hasExactSynonym "Pontine hypoplasia" ; oboInOwl:id "HP:0012110" ; a owl:Class ; rdfs:label "Hypoplasia of the pons" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0007361 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012111 obo:IAO_0000115 "An abnormality of the concentration of a glucocorticoid in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T04:22:26Z" ; oboInOwl:hasDbXref "UMLS:C4023038" ; oboInOwl:id "HP:0012111" ; a owl:Class ; rdfs:label "Abnormality of circulating glucocorticoid level" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24261 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012112 obo:IAO_0000115 "An abnormality of the concentration of corticosterone in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T04:23:55Z" ; oboInOwl:hasDbXref "UMLS:C4023037" ; oboInOwl:hasExactSynonym "Abnormality of circulating corticosterone level" ; oboInOwl:id "HP:0012112" ; a owl:Class ; rdfs:label "Abnormal circulating corticosterone level" ; rdfs:subClassOf obo:HP_0012111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16827 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012113 obo:IAO_0000115 "A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarly for muscle cells." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T04:29:41Z" ; oboInOwl:hasDbXref "UMLS:C4020731" ; oboInOwl:hasExactSynonym "Abnormality of creatine metabolism" ; oboInOwl:hasRelatedSynonym "Creatine metabolism abnormal" ; oboInOwl:id "HP:0012113" ; a owl:Class ; rdfs:label "Abnormal circulating creatine concentration" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006600 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012114 obo:IAO_0000115 "A carcinoma of the endometrium, the mucous lining of the uterus." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T04:37:32Z" ; oboInOwl:hasDbXref "MSH:D016889", "SNOMEDCT_US:254878006", "UMLS:C0476089" ; oboInOwl:id "HP:0012114" ; a owl:Class ; rdfs:label "Endometrial carcinoma" ; rdfs:subClassOf obo:HP_0010784, obo:HP_0030126 . obo:HP_0012115 obo:IAO_0000115 "Inflammation of the liver." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T05:03:29Z" ; oboInOwl:hasDbXref "MSH:D006505", "SNOMEDCT_US:128241005", "UMLS:C0019158" ; oboInOwl:hasExactSynonym "Liver inflammation" ; oboInOwl:id "HP:0012115" ; a owl:Class ; rdfs:label "Hepatitis" ; rdfs:subClassOf obo:HP_0012649, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012116 obo:IAO_0000115 "Deviation from normal concentration of albumin in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T05:14:53Z" ; oboInOwl:hasDbXref "UMLS:C4023036" ; oboInOwl:hasExactSynonym "Abnormal albumin level" ; oboInOwl:id "HP:0012116" ; a owl:Class ; rdfs:label "Abnormal circulating albumin concentration" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012117 obo:IAO_0000115 "Elevation in the concentration of albumin in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T05:15:41Z" ; oboInOwl:hasBroadSynonym "High albumin" ; oboInOwl:hasDbXref "SNOMEDCT_US:119248009", "UMLS:C1142113" ; oboInOwl:hasExactSynonym "High blood albumin levels", "Hyperalbuminaemia" ; oboInOwl:id "HP:0012117" ; a owl:Class ; rdfs:label "Hyperalbuminemia" ; rdfs:subClassOf obo:HP_0012116 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012118 obo:IAO_0000115 "A carcinoma of the larynx." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T05:28:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:276975007", "UMLS:C0595989" ; oboInOwl:hasExactSynonym "Cancer of the larynx", "Laryngeal cancer" ; oboInOwl:id "HP:0012118" ; a owl:Class ; rdfs:comment "Laryngeal carcinoma often is related to a history of smoking and may manifest by hoarseness, a lump in the neck, persistent cough, stridor and other symptoms." ; rdfs:label "Laryngeal carcinoma" ; rdfs:subClassOf obo:HP_0100605 . obo:HP_0012119 obo:IAO_0000115 "Abnormally increased levels of methemoglobin in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T05:42:35Z" ; oboInOwl:hasDbXref "MSH:D008708", "SNOMEDCT_US:131171006", "SNOMEDCT_US:38959009", "UMLS:C0025637" ; oboInOwl:id "HP:0012119" ; a owl:Class ; rdfs:label "Methemoglobinemia" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0012120 obo:IAO_0000115 "Increased concentration of methylmalonic acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:02:23Z" ; oboInOwl:hasDbXref "MSH:C537358", "UMLS:C1855119" ; oboInOwl:hasExactSynonym "High blood methylmalonic acid levels", "Methymalonicaciduria" ; oboInOwl:id "HP:0012120" ; a owl:Class ; rdfs:comment "Methylmalonic aciduria is a genetically heterogeneous disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism." ; rdfs:label "Methylmalonic aciduria" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012121 obo:IAO_0000115 "Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:23:34Z" ; oboInOwl:hasDbXref "MSH:D015864", "SNOMEDCT_US:75614007", "UMLS:C0030343" ; oboInOwl:id "HP:0012121" ; a owl:Class ; rdfs:label "Panuveitis" ; rdfs:subClassOf obo:HP_0000554 . obo:HP_0012122 obo:IAO_0000115 "Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:24:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:4927003", "UMLS:C0701807" ; oboInOwl:id "HP:0012122" ; a owl:Class ; rdfs:label "Anterior uveitis" ; rdfs:subClassOf obo:HP_0000554 . obo:HP_0012123 obo:IAO_0000115 "Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:25:06Z" ; oboInOwl:hasDbXref "MSH:D002833", "MSH:D015866", "SNOMEDCT_US:16553002", "SNOMEDCT_US:43363007", "UMLS:C0008526", "UMLS:C0042167" ; oboInOwl:hasExactSynonym "Choroiditis" ; oboInOwl:id "HP:0012123" ; a owl:Class ; rdfs:label "Posterior uveitis" ; rdfs:subClassOf obo:HP_0000554 . obo:HP_0012124 obo:IAO_0000115 "Inflammation of the uveal tract in which the primary site of inflammation is the vitreous." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:25:53Z" ; oboInOwl:hasDbXref "MSH:D015867", "SNOMEDCT_US:314429009", "UMLS:C0042166" ; oboInOwl:id "HP:0012124" ; a owl:Class ; rdfs:label "Intermediate uveitis" ; rdfs:subClassOf obo:HP_0000554 . obo:HP_0012125 obo:IAO_0000115 "A cancer of the prostate." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:33:32Z" ; oboInOwl:hasDbXref "MSH:D011471", "SNOMEDCT_US:399068003", "UMLS:C0376358" ; oboInOwl:hasExactSynonym "Prostatic cancer" ; oboInOwl:id "HP:0012125" ; a owl:Class ; rdfs:label "Prostate cancer" ; rdfs:subClassOf obo:HP_0100787 . obo:HP_0012126 obo:IAO_0000115 "A cancer arising in any part of the stomach." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:45:29Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:372143007", "UMLS:C0699791" ; oboInOwl:hasExactSynonym "Gastric cancer" ; oboInOwl:id "HP:0012126" ; a owl:Class ; rdfs:label "Stomach cancer" ; rdfs:subClassOf obo:HP_0006753 . obo:HP_0012127 obo:IAO_0000115 "Increased concentration of uracil in the urine." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T06:53:53Z" ; oboInOwl:hasDbXref "UMLS:C4021833" ; oboInOwl:hasExactSynonym "High urine uracil levels" ; oboInOwl:id "HP:0012127" ; a owl:Class ; rdfs:label "Uraciluria" ; rdfs:subClassOf obo:HP_0033162 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012128 obo:IAO_0000115 "Death of cells in the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:00:22Z" ; oboInOwl:hasDbXref "UMLS:C4023035" ; oboInOwl:id "HP:0012128" ; a owl:Class ; rdfs:label "Basal ganglia necrosis" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012129 dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:13:26Z" ; oboInOwl:hasDbXref "UMLS:C4023034" ; oboInOwl:id "HP:0012129" ; a owl:Class ; rdfs:label "Abnormality of bone marrow stromal cells" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0012130 obo:IAO_0000115 "An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:14:03Z" ; oboInOwl:hasDbXref "UMLS:C4020862" ; oboInOwl:hasExactSynonym "Abnormality of cells of the erythroid lineage" ; oboInOwl:id "HP:0012130" ; a owl:Class ; rdfs:label "Abnormal erythroid lineage cell morphology" ; rdfs:subClassOf obo:HP_0020047 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000764 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012131 obo:IAO_0000115 "A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:17:18Z" ; oboInOwl:hasDbXref "UMLS:C4023033" ; oboInOwl:id "HP:0012131" ; a owl:Class ; rdfs:label "Abnormal number of erythroid precursors" ; rdfs:subClassOf obo:HP_0001877 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000038 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012132 obo:IAO_0000115 "Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:19:21Z" ; oboInOwl:hasDbXref "UMLS:C0014800", "UMLS:C1838111", "UMLS:C3552917" ; oboInOwl:hasRelatedSynonym "Bone marrow biopsy shows erythroid hyperplasia", "Bone marrow smear shows erythroid hyperplasia" ; oboInOwl:id "HP:0012132" ; a owl:Class ; rdfs:label "Erythroid hyperplasia" ; rdfs:subClassOf obo:HP_0012131 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000038 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012133 obo:IAO_0000115 "Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T07:21:19Z" ; oboInOwl:hasDbXref "MSH:D000741", "SNOMEDCT_US:167923006", "SNOMEDCT_US:41614006", "UMLS:C0178416", "UMLS:C0542035" ; oboInOwl:hasExactSynonym "Erythroblastopenia" ; oboInOwl:hasRelatedSynonym "Erythroid hypoplasia in the bone marrow" ; oboInOwl:id "HP:0012133" ; a owl:Class ; rdfs:label "Erythroid hypoplasia" ; rdfs:subClassOf obo:HP_0012131 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000038 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012134 dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:01:11Z" ; oboInOwl:hasDbXref "UMLS:C4023032" ; oboInOwl:id "HP:0012134" ; a owl:Class ; rdfs:label "Dysplastic erythropoesis" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0012135 obo:IAO_0000115 "An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:02:11Z" ; oboInOwl:hasDbXref "UMLS:C4023031" ; oboInOwl:hasExactSynonym "Abnormality of cells of the granulocytic lineage" ; oboInOwl:id "HP:0012135" ; a owl:Class ; rdfs:label "Abnormal granulocytopoietic cell morphology" ; rdfs:subClassOf obo:HP_0005561 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0002191 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012136 dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:05:13Z" ; oboInOwl:hasDbXref "UMLS:C4023030" ; oboInOwl:id "HP:0012136" ; a owl:Class ; rdfs:label "Dysplastic granulopoesis" ; rdfs:subClassOf obo:HP_0012135 . obo:HP_0012137 dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:09:13Z" ; oboInOwl:hasDbXref "UMLS:C4023029" ; oboInOwl:id "HP:0012137" ; a owl:Class ; rdfs:label "Abnormal number of granulocyte precursors" ; rdfs:subClassOf obo:HP_0012135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002083 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0002191 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012138 dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:09:36Z" ; oboInOwl:hasDbXref "UMLS:C4023028" ; oboInOwl:id "HP:0012138" ; a owl:Class ; rdfs:label "Granulocytic hyperplasia" ; rdfs:subClassOf obo:HP_0012137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0002191 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012139 obo:IAO_0000115 "Decreased number of granulocyte precursors in the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:09:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:416627004", "UMLS:C1534864" ; oboInOwl:id "HP:0012139" ; a owl:Class ; rdfs:label "Granulocytic hypoplasia" ; rdfs:subClassOf obo:HP_0012137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0002191 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012140 obo:IAO_0100001 "HP:0004332" ; oboInOwl:id "HP:0012140" ; a owl:Class ; rdfs:label "obsolete Abnormality of cells of the lymphoid lineage" ; owl:deprecated true . obo:HP_0012142 obo:IAO_0000115 "A subtype of ductal pancreatic carcinoma that is thought to originate from squamous metaplasia of pancreatic ductal epithelium." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:55:24Z" ; oboInOwl:hasDbXref "UMLS:C2675993" ; oboInOwl:hasExactSynonym "Squamous cell carcinoma of the pancreas" ; oboInOwl:id "HP:0012142" ; a owl:Class ; rdfs:label "Pancreatic squamous cell carcinoma" ; rdfs:subClassOf obo:HP_0002894 . obo:HP_0012143 obo:IAO_0000115 "Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:20:38Z" ; oboInOwl:hasDbXref "UMLS:C4023026" ; oboInOwl:hasExactSynonym "Abnormality of cells of the megakaryocyte lineage" ; oboInOwl:id "HP:0012143" ; a owl:Class ; rdfs:label "Abnormal megakaryocyte morphology" ; rdfs:subClassOf obo:HP_0005561 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000556 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012144 obo:IAO_0000115 "Any structural anomaly of a myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:21:37Z" ; oboInOwl:hasDbXref "UMLS:C4023025" ; oboInOwl:id "HP:0012144" ; a owl:Class ; rdfs:label "Abnormal monocyte morphology" ; rdfs:subClassOf obo:HP_0010974 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012145 dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:21:57Z" ; oboInOwl:hasDbXref "UMLS:C4023024" ; oboInOwl:id "HP:0012145" ; a owl:Class ; rdfs:label "Abnormality of multiple cell lineages in the bone marrow" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0012146 obo:IAO_0000115 "Decreased quantity or activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:25:58Z" ; oboInOwl:hasDbXref "UMLS:C4023023" ; oboInOwl:id "HP:0012146" ; a owl:Class ; rdfs:label "Abnormality of von Willebrand factor" ; rdfs:subClassOf obo:HP_0003256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000017364 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012147 obo:IAO_0000115 "Decreased quantity of von Willebrand factor." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:27:00Z" ; oboInOwl:hasDbXref "UMLS:C1841816", "UMLS:C4023022" ; oboInOwl:hasRelatedSynonym "Decreased von Willebrand factor" ; oboInOwl:id "HP:0012147" ; a owl:Class ; rdfs:label "Reduced quantity of Von Willebrand factor" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0012148 obo:IAO_0000115 "Myelodysplasia with dysplastic changes in two or more of the myeloid lineages: erythroid, granulocytic, megakaryocytic." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:33:33Z" ; oboInOwl:hasDbXref "UMLS:C4023021" ; oboInOwl:id "HP:0012148" ; a owl:Class ; rdfs:label "Multiple lineage myelodysplasia" ; rdfs:subClassOf obo:HP_0002863 . obo:HP_0012149 obo:IAO_0000115 "Myelodysplasia with dysplastic changes in two of the myeloid lineages: erythroid, granulocytic, megakaryocytic." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:39:10Z" ; oboInOwl:hasDbXref "UMLS:C4023020" ; oboInOwl:id "HP:0012149" ; a owl:Class ; rdfs:label "Bilineage myelodysplasia" ; rdfs:subClassOf obo:HP_0002863 . obo:HP_0012150 obo:IAO_0000115 "Abnormality/dysplasia of a single myeloid cell (erythroid, granulocytic, or megakaryocytic)." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:39:39Z" ; oboInOwl:hasDbXref "UMLS:C4023019" ; oboInOwl:id "HP:0012150" ; a owl:Class ; rdfs:label "Single lineage myelodysplasia" ; rdfs:subClassOf obo:HP_0002863 . obo:HP_0012151 obo:IAO_0000115 "The presence of blood in the pleural space." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T08:58:32Z" ; oboInOwl:hasDbXref "MSH:D006491", "SNOMEDCT_US:31892009", "UMLS:C0019123" ; oboInOwl:id "HP:0012151" ; a owl:Class ; rdfs:comment "Hemothorax may result from hemorrhage in the chest wall, lung parenchyma, heart, or great vessels." ; rdfs:label "Hemothorax" ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0012152 obo:IAO_0000115 "Splitting of the retinal layers in the macula." ; dcterms:creator ; oboInOwl:creation_date "2012-09-16T09:06:26Z" ; oboInOwl:hasDbXref "UMLS:C2674407" ; oboInOwl:hasExactSynonym "Retinoschisis involving the fovea" ; oboInOwl:id "HP:0012152" ; a owl:Class ; rdfs:label "Foveoschisis" ; rdfs:subClassOf obo:HP_0000493, obo:HP_0030502 . obo:HP_0012153 obo:IAO_0000115 "An decrease in the level of triglycerides in the blood." ; dcterms:creator ; oboInOwl:creation_date "2012-09-20T06:39:11Z" ; oboInOwl:hasDbXref "UMLS:C0542037" ; oboInOwl:hasExactSynonym "Decreased circulating Tg levels", "Decreased plasma Tg levels", "Low blood triglyceride levels" ; oboInOwl:id "HP:0012153" ; a owl:Class ; rdfs:label "Hypotriglyceridemia" ; rdfs:subClassOf obo:HP_0045014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17855 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012154 obo:IAO_0000115 "Inability to experience pleasure activities usually found enjoyable." ; dcterms:creator ; oboInOwl:creation_date "2012-09-20T06:51:36Z" ; oboInOwl:hasDbXref "MSH:D059445", "SNOMEDCT_US:247796005", "SNOMEDCT_US:28669007", "UMLS:C0178417" ; oboInOwl:id "HP:0012154" ; a owl:Class ; rdfs:label "Anhedonia" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0012155 obo:IAO_0000115 "Reduced ability of the cornea to respond to stimulation." ; dcterms:creator ; oboInOwl:creation_date "2013-01-04T08:36:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:373433005", "UMLS:C0271292", "UMLS:C0859996" ; oboInOwl:hasExactSynonym "Corneal hypaesthesia", "Corneal hypesthesia", "Reduced corneal sensation" ; oboInOwl:hasRelatedSynonym "Decreased corneal sensitivity" ; oboInOwl:id "HP:0012155" ; a owl:Class ; rdfs:comment "Corneal sensitivity to touch can be assessed by an aesthesiometer, which measures the corneal touch threshold. Decreased corneal sensation is associated with a decreased corneal reflex (HP:0008000); however, impairment of the corneal reflex can have other causes such as trigeminal nerve compression or a cerebellopontine angle lesion. Well known causes of decreased corneal sensation include Herpes simplex keratitis, neuroparalytic keratitis, leprosy, acoustic neuroma, and absolute glaucoma." ; rdfs:label "Decreased corneal sensation" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0012156 obo:IAO_0000115 "Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues." ; dcterms:creator ; oboInOwl:creation_date "2013-01-07T10:11:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:61070002", "UMLS:C0876991" ; oboInOwl:id "HP:0012156" ; a owl:Class ; rdfs:comment "Hemophagocytosis is a nonspecific phenotypic feature observed in several conditions including hemolytic anemia, malignant disease, infections, and hemophagocytic syndrome (also known as hemophagocytic lymphohistiocytosis, a rare hyperinflammatory syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune process)." ; rdfs:label "Hemophagocytosis" ; rdfs:subClassOf obo:HP_0004311 . obo:HP_0012157 obo:IAO_0000115 "Atrophy of the cerebral subcortical white and gray matter, termed subcortical atrophy, reflects loss of nerve cells in the basal ganglia or fibers in the deep white matter." ; dcterms:creator ; oboInOwl:creation_date "2013-01-20T11:22:50Z" ; oboInOwl:hasDbXref "UMLS:C4023018" ; oboInOwl:id "HP:0012157" ; a owl:Class ; rdfs:label "Subcortical cerebral atrophy" ; rdfs:subClassOf obo:HP_0007369 . obo:HP_0012158 obo:IAO_0000115 "A separation (dissection) of the layers of the carotid artery wall." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T07:19:57Z" ; oboInOwl:hasDbXref "UMLS:C0338585" ; oboInOwl:id "HP:0012158" ; a owl:Class ; rdfs:label "Carotid artery dissection" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0012159 obo:IAO_0000115 "A separation (dissection) of the layers of the internal carotid artery wall." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T07:22:28Z" ; oboInOwl:hasDbXref "MSH:D020215", "SNOMEDCT_US:705066004", "UMLS:C0751815" ; oboInOwl:id "HP:0012159" ; a owl:Class ; rdfs:comment "The internal carotid begins at the bifurcation of the common carotid, opposite the upper border of the thyroid cartilage, and runs perpendicularly upward. It supplies the anterior part of the brain, the eye and its appendages, and sends branches to the forehead and nose. Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation." ; rdfs:label "Internal carotid artery dissection" ; rdfs:subClassOf obo:HP_0012158 . obo:HP_0012160 obo:IAO_0000115 "A separation (dissection) of the layers of the intracranial portion of the internal carotid artery wall." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T07:31:51Z" ; oboInOwl:hasDbXref "UMLS:C4023017" ; oboInOwl:id "HP:0012160" ; a owl:Class ; rdfs:label "Intracranial internal carotid artery dissection" ; rdfs:subClassOf obo:HP_0012159 . obo:HP_0012161 obo:IAO_0000115 "A separation (dissection) of the layers of the external carotid artery wall." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T07:33:34Z" ; oboInOwl:hasDbXref "UMLS:C4023016" ; oboInOwl:id "HP:0012161" ; a owl:Class ; rdfs:label "External carotid artery dissection" ; rdfs:subClassOf obo:HP_0012158 . obo:HP_0012162 obo:IAO_0000115 "A separation (dissection) of the layers of the common carotid artery wall." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T07:34:14Z" ; oboInOwl:hasDbXref "UMLS:C4023015" ; oboInOwl:id "HP:0012162" ; a owl:Class ; rdfs:label "Common carotid artery dissection" ; rdfs:subClassOf obo:HP_0012158 . obo:HP_0012163 obo:IAO_0000115 "A dilatation (balooning or bulging out of the vessel wall) of a carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T10:18:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:233988005", "UMLS:C0340639" ; oboInOwl:hasNarrowSynonym "Carotid artery aneurysm" ; oboInOwl:id "HP:0012163" ; a owl:Class ; rdfs:label "Carotid artery dilatation" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0012164 obo:IAO_0000115 "A clinical sign indicating a lapse of posture and is usually manifest by a bilateral flapping tremor at the wrist, metacarpophalangeal, and hip joints." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T10:20:08Z" ; oboInOwl:hasDbXref "MSH:D020820", "SNOMEDCT_US:32838008", "UMLS:C0232766" ; oboInOwl:id "HP:0012164" ; a owl:Class ; rdfs:comment "The examiner can test for asterixis by asking the patient to extend the arms, spread the fingers, dorsiflex the wrist and observe for the abnormal \"flapping\" tremor at the wrist. Asterixis represents the failure to actively maintain a position and is caused by the abnormal function of diencephalic motor centers that regulate the tone of the agonist and antagonist muscles involved in maintaining posture." ; rdfs:label "Asterixis" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0012165 obo:IAO_0000115 "A developmental defect resulting in the presence of fewer than the normal number of digits." ; dcterms:creator ; oboInOwl:creation_date "2013-02-16T10:44:40Z" ; oboInOwl:hasDbXref "UMLS:C3887496" ; oboInOwl:id "HP:0012165" ; a owl:Class ; rdfs:label "Oligodactyly" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012166 obo:IAO_0000115 "Repetitive and compulsive picking of skin which results in tissue damage." ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T07:12:33Z" ; oboInOwl:hasDbXref "ICD-10:F63.3", "UMLS:C1696701" ; oboInOwl:hasExactSynonym "Compulsive skin picking", "Dermatillomania" ; oboInOwl:id "HP:0012166" ; a owl:Class ; rdfs:label "Skin-picking" ; rdfs:subClassOf obo:HP_0100716 . obo:HP_0012167 obo:IAO_0000115 "A phenomenon in which persons repetitively pull out their own hair, resulting in noticeable hair loss." ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T07:16:10Z" ; oboInOwl:hasDbXref "MSH:D014256", "SNOMEDCT_US:17155009", "UMLS:C0040953" ; oboInOwl:hasExactSynonym "Trichotillomania" ; oboInOwl:id "HP:0012167" ; a owl:Class ; rdfs:label "Hair-pulling" ; rdfs:subClassOf obo:HP_0100716 . obo:HP_0012168 obo:IAO_0000115 "Habitual striking of one's own head against a surface such as a mattress or wall of a crib." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T09:33:57Z" ; oboInOwl:hasDbXref "MSH:D019956", "SNOMEDCT_US:43954004", "UMLS:C0018672" ; oboInOwl:id "HP:0012168" ; a owl:Class ; rdfs:label "Head-banging" ; rdfs:subClassOf obo:HP_0100716, obo:HP_5200017 . obo:HP_0012169 obo:IAO_0000115 "Habitual biting of one's own body." ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T09:36:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:248072009", "UMLS:C0424375" ; oboInOwl:id "HP:0012169" ; a owl:Class ; rdfs:comment "Biting of one's own arms, lip, check, finger etc." ; rdfs:label "Self-biting" ; rdfs:subClassOf obo:HP_0100716 . obo:HP_0012170 obo:IAO_0000115 "Habitual biting of one's own fingernails." ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T09:40:31Z" ; oboInOwl:hasDbXref "ICD-10:F98.8", "MSH:D009259", "SNOMEDCT_US:37298006", "UMLS:C0027338" ; oboInOwl:hasExactSynonym "Nail-biting", "Onychophagia", "Onychophagy" ; oboInOwl:id "HP:0012170" ; a owl:Class ; rdfs:label "Nail-biting" ; rdfs:subClassOf obo:HP_0012169 . obo:HP_0012171 obo:IAO_0000115 "Habitual clasping and wringing of the hands in the middle of the body, similar to a hand-washing movement." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T09:44:45Z" ; oboInOwl:hasDbXref "UMLS:C4023014" ; oboInOwl:hasExactSynonym "Hand clasping", "Hand-wringing", "Handwringing" ; oboInOwl:id "HP:0012171" ; a owl:Class ; rdfs:label "Stereotypical hand wringing" ; rdfs:subClassOf obo:HP_5200009 . obo:HP_0012172 obo:IAO_0000115 "Habitual repetitive movement of the entire body, front to back or side to side." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2013-02-20T10:17:35Z" ; oboInOwl:hasDbXref "UMLS:C4023013" ; oboInOwl:id "HP:0012172" ; a owl:Class ; rdfs:label "Stereotypical body rocking" ; rdfs:subClassOf obo:HP_5200019 . obo:HP_0012173 obo:IAO_0000115 "An increase in heart rate with standing of 30 beats per minute or more." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T09:42:20Z" ; oboInOwl:hasDbXref "UMLS:C4021099" ; oboInOwl:hasExactSynonym "Postural tachycardia" ; oboInOwl:id "HP:0012173" ; a owl:Class ; rdfs:label "Orthostatic tachycardia" ; rdfs:subClassOf obo:HP_0012332 . obo:HP_0012174 obo:IAO_0000115 "A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T09:47:02Z" ; oboInOwl:hasAlternativeId "HP:0100843" ; oboInOwl:hasDbXref "MSH:D005909", "SNOMEDCT_US:393563007", "SNOMEDCT_US:63634009", "UMLS:C1621958" ; oboInOwl:hasExactSynonym "Glioblastoma" ; oboInOwl:id "HP:0012174" ; a owl:Class ; rdfs:label "Glioblastoma multiforme" ; rdfs:subClassOf obo:HP_0009733 . obo:HP_0012175 obo:IAO_0000115 "Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T09:54:07Z" ; oboInOwl:hasDbXref "MSH:D020016", "SNOMEDCT_US:421527008", "UMLS:C0600433" ; oboInOwl:hasExactSynonym "Activated protein C resistance" ; oboInOwl:id "HP:0012175" ; a owl:Class ; rdfs:comment "The protein C pathway is a major anticoagulant mechanism that down-regulates the prothrombin- and intrinsic factor X (FX)-activating complexes via inactivation of their respective cofactors, activated factors V (FVa) and VIII (FVIIIa). Cofactor inactivation occurs by limited proteolysis at certain amino acid positions in FVa and in FVIIIa. These reactions are catalyzed by the serine protease activated protein C (APC) and stimulated by the APC cofactor protein S. Functional defects of the protein C pathway determine a plasma phenotype known as APC resistance, which is a prevalent and important risk factor for venous thrombosis. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time (aPTT) assay." ; rdfs:label "Resistance to activated protein C" ; rdfs:subClassOf obo:HP_0030780 . obo:HP_0012176 obo:IAO_0000115 "An anomaly of the natural killer cell, which is a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors. It also regulates immune responses via cytokine release and direct contact with other cells." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:02:16Z" ; oboInOwl:hasDbXref "UMLS:C4021098" ; oboInOwl:hasExactSynonym "Abnormal NK cells", "Abnormality of natural killer cells" ; oboInOwl:id "HP:0012176" ; a owl:Class ; rdfs:label "Abnormal natural killer cell morphology" ; rdfs:subClassOf obo:HP_0004332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012177 obo:IAO_0000115 "A functional anomaly of the natural killer cell." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:03:37Z" ; oboInOwl:hasDbXref "UMLS:C4023012" ; oboInOwl:id "HP:0012177" ; a owl:Class ; rdfs:label "Abnormal natural killer cell physiology" ; rdfs:subClassOf obo:HP_0031409 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012178 obo:IAO_0000115 "Reduced ability of the natural killer cell to function in the adaptive immune response." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:05:33Z" ; oboInOwl:hasDbXref "UMLS:C1839969" ; oboInOwl:id "HP:0012178" ; a owl:Class ; rdfs:label "Reduced natural killer cell activity" ; rdfs:subClassOf obo:HP_0012177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001624 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012179 obo:IAO_0000115 "A form of focal dystonia affecting the face and especially the jaw that is induced by the act of speaking. It is an involuntary contraction of the masticatory muscles, resulting in dysarthria or dysphagia." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:10:32Z" ; oboInOwl:hasBroadSynonym "Abnormal craniofacial posture", "Distorted craniofacial posture" ; oboInOwl:hasDbXref "UMLS:C1851915", "UMLS:C4023011", "UMLS:C4072883" ; oboInOwl:hasExactSynonym "Abnormal craniofacial muscle tone" ; oboInOwl:hasNarrowSynonym "Abnormal facial muscle tone", "Facial Dystonia" ; oboInOwl:id "HP:0012179" ; a owl:Class ; rdfs:label "Craniofacial dystonia" ; rdfs:subClassOf obo:HP_0004373 . obo:HP_0012180 obo:IAO_0000115 "A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:17:16Z" ; oboInOwl:hasAlternativeId "HP:0200145" ; oboInOwl:hasDbXref "MSH:C536230", "SNOMEDCT_US:234021009", "SNOMEDCT_US:42182000", "SNOMEDCT_US:45894003", "UMLS:C0392775" ; oboInOwl:hasExactSynonym "Arterial cystic medial necrosis" ; oboInOwl:id "HP:0012180" ; a owl:Class ; rdfs:comment "The lesions of cystic medial necrosis are not true cysts." ; rdfs:label "Cystic medial necrosis" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0012181 obo:IAO_0000115 "Malfunction of a peripheral nerve resulting from mechanical compression of the nerve roots from internal or external causes and leading to a conduction block or axonal loss." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:20:59Z" ; oboInOwl:hasDbXref "MSH:D009408", "SNOMEDCT_US:45781009", "UMLS:C1510429" ; oboInOwl:id "HP:0012181" ; a owl:Class ; rdfs:comment "An entrapment neuropathy is an isolated peripheral nerve injury due to mechanical contriction in a fibrous or fibro-osseous tunnel or to deformation of the nerve by a fibrous band." ; rdfs:label "Entrapment neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0012182 obo:IAO_0000115 "A squamous cell carcinoma that originates in the oropharnyx." ; dcterms:creator ; oboInOwl:creation_date "2013-02-23T10:28:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:423464009", "SNOMEDCT_US:707585008", "UMLS:C0280313" ; oboInOwl:id "HP:0012182" ; a owl:Class ; rdfs:label "Oropharyngeal squamous cell carcinoma" ; rdfs:subClassOf obo:HP_0002860 . obo:HP_0012183 obo:IAO_0000115 "Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:08:55Z" ; oboInOwl:hasDbXref "UMLS:C4023010" ; oboInOwl:id "HP:0012183" ; a owl:Class ; rdfs:label "Hyperplastic colonic polyposis" ; rdfs:subClassOf obo:HP_0030255 . obo:HP_0012184 obo:IAO_0000115 "An elevated concentration of high-density lipoprotein cholesterol (HDL) in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:14:45Z" ; oboInOwl:hasDbXref "MSH:C564591", "SNOMEDCT_US:238080004", "UMLS:C0342883" ; oboInOwl:hasExactSynonym "High blood HDL level", "Hyperalphalipoproteinemia", "Increased circulating high-density lipoprotein levels" ; oboInOwl:id "HP:0012184" ; a owl:Class ; rdfs:comment "The major apolipoproteins of HDL are apolipoprotein (apo) A-I and apo A-II, also known as the alpha lipoproteins. Thus, hyperalphalipoproteinemia refers to an elevated concentration of apo A-I and apo A-II." ; rdfs:label "Increased HDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010980, obo:HP_0031888 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012185 obo:IAO_0000115 "Injury to the median nerve caused by its entrapment at the wrist as it traverses through the carpal tunnel. Clinically, constrictive median neuropathy is characterized by pain, paresthesia, and weakness in the median nerve distribution of the hand." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:24:32Z" ; oboInOwl:hasDbXref "UMLS:C4023009" ; oboInOwl:hasRelatedSynonym "Carpal tunnel syndrome" ; oboInOwl:id "HP:0012185" ; a owl:Class ; rdfs:comment "Constrictive median neuropathy is the major clinical feature of carpal tunnel syndrome." ; rdfs:label "Constrictive median neuropathy" ; rdfs:subClassOf obo:HP_0012181 . obo:HP_0012186 obo:IAO_0000115 "An entrapment neuropathy of the ulnar nerve in the cubital tunnel (in the elbow) characterized by numbness in the ring and little fingers and weakness of the intrinsic muscles in the hand." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:27:57Z" ; oboInOwl:hasDbXref "UMLS:C4023008" ; oboInOwl:id "HP:0012186" ; a owl:Class ; rdfs:label "Entrapment neuropathy of the ulnar nerve at elbow" ; rdfs:subClassOf obo:HP_0012181 . obo:HP_0012187 obo:IAO_0000115 "Concentration of protoporphyrins in erythrocytes above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:49:59Z" ; oboInOwl:hasDbXref "UMLS:C4023007" ; oboInOwl:id "HP:0012187" ; a owl:Class ; rdfs:label "Increased erythrocyte protoporphyrin concentration" ; rdfs:subClassOf obo:HP_0034606 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012188 obo:IAO_0000115 "Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight." ; dcterms:creator ; oboInOwl:creation_date "2013-02-24T09:58:18Z" ; oboInOwl:hasDbXref "MSH:D006939", "SNOMEDCT_US:14094001", "UMLS:C0020450" ; oboInOwl:id "HP:0012188" ; a owl:Class ; rdfs:label "Hyperemesis gravidarum" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0012189 obo:IAO_0000115 "A type of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T06:53:11Z" ; oboInOwl:hasDbXref "MSH:D006689", "SNOMEDCT_US:118599009", "SNOMEDCT_US:118602004", "SNOMEDCT_US:118605002", "SNOMEDCT_US:118606001", "SNOMEDCT_US:14537002", "SNOMEDCT_US:46923007", "SNOMEDCT_US:70600005", "SNOMEDCT_US:74189002", "UMLS:C0019829" ; oboInOwl:hasExactSynonym "Hodgkin disease", "Hodgkin's lymphoma" ; oboInOwl:id "HP:0012189" ; a owl:Class ; rdfs:label "Hodgkin lymphoma" ; rdfs:subClassOf obo:HP_0002665 . obo:HP_0012190 obo:IAO_0000115 "A type of lymphoma that originates in T-cells." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T06:56:11Z" ; oboInOwl:hasDbXref "MSH:D016399", "SNOMEDCT_US:109978004", "SNOMEDCT_US:3172003", "UMLS:C0079772" ; oboInOwl:hasExactSynonym "T cell lymphoma" ; oboInOwl:id "HP:0012190" ; a owl:Class ; rdfs:label "T-cell lymphoma" ; rdfs:subClassOf obo:HP_0012539 . obo:HP_0012191 obo:IAO_0000115 "A type of lymphoma that originates in B-cells." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T06:59:05Z" ; oboInOwl:hasDbXref "MSH:D016393", "SNOMEDCT_US:109979007", "SNOMEDCT_US:1929004", "SNOMEDCT_US:413616009", "UMLS:C0079731" ; oboInOwl:hasExactSynonym "B cell lymphoma" ; oboInOwl:id "HP:0012191" ; a owl:Class ; rdfs:label "B-cell lymphoma" ; rdfs:subClassOf obo:HP_0012539 . obo:HP_0012192 obo:IAO_0000115 "A type of T-cell lymphoma that exhibits malignant infiltration of the skin." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T07:03:19Z" ; oboInOwl:hasDbXref "MSH:D016410", "SNOMEDCT_US:28054005", "SNOMEDCT_US:400122007", "UMLS:C0079773" ; oboInOwl:id "HP:0012192" ; a owl:Class ; rdfs:label "Cutaneous T-cell lymphoma" ; rdfs:subClassOf obo:HP_0012190 . obo:HP_0012193 obo:IAO_0000115 "A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T07:15:32Z" ; oboInOwl:hasDbXref "MSH:D017728", "SNOMEDCT_US:277637000", "SNOMEDCT_US:53237008", "UMLS:C0206180" ; oboInOwl:id "HP:0012193" ; a owl:Class ; rdfs:label "Anaplastic large-cell lymphoma" ; rdfs:subClassOf obo:HP_0012190 . obo:HP_0012194 obo:IAO_0000115 "Transient episodes of weakness of the arm, leg, and in some cases the face on one side of the body." ; dcterms:creator ; oboInOwl:creation_date "2013-02-27T07:26:26Z" ; oboInOwl:hasDbXref "UMLS:C1863061" ; oboInOwl:id "HP:0012194" ; a owl:Class ; rdfs:label "Episodic hemiplegia" ; rdfs:subClassOf obo:HP_0002301 . obo:HP_0012195 obo:IAO_0000115 "Uneven rhythm of breathing." ; dcterms:creator ; oboInOwl:creation_date "2013-03-11T05:10:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:248585001", "UMLS:C0425492" ; oboInOwl:hasExactSynonym "Irregular respiratory rhythm" ; oboInOwl:id "HP:0012195" ; a owl:Class ; rdfs:label "Irregular respiration" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0012196 obo:IAO_0000115 "An abnormal pattern of respiration characterized by cycles of respiration that are increasingly deeper then shallower with possible periods of apnea. Affected patients may display a 10 to 20 second episode of hypoventilation or apnea, followed by respiration of increased depth and frequency over the course of about one minute. The cycle repeats every 45 seconds to 3 minutes." ; dcterms:creator ; oboInOwl:creation_date "2013-03-11T07:00:56Z" ; oboInOwl:hasDbXref "MSH:D002639", "SNOMEDCT_US:271824009", "SNOMEDCT_US:309155007", "UMLS:C0008039", "UMLS:C1313952" ; oboInOwl:hasExactSynonym "Cheyne-Stokes breathing", "Periodic respiration" ; oboInOwl:id "HP:0012196" ; a owl:Class ; rdfs:label "Cheyne-Stokes respiration" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0012197 obo:IAO_0000115 "A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia." ; dcterms:creator ; oboInOwl:creation_date "2013-03-11T07:06:29Z" ; oboInOwl:hasDbXref "MSH:D007340", "SNOMEDCT_US:25324008", "SNOMEDCT_US:302822000", "UMLS:C0021670" ; oboInOwl:hasExactSynonym "Pancreatic insulinoma" ; oboInOwl:id "HP:0012197" ; a owl:Class ; rdfs:label "Insulinoma" ; rdfs:subClassOf obo:HP_0008261 . obo:HP_0012198 obo:IAO_0000115 "The presence of more than 5 juvenile polyps of the colon. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands." ; dcterms:creator ; oboInOwl:creation_date "2013-03-11T07:09:42Z" ; oboInOwl:hasDbXref "UMLS:C4023006" ; oboInOwl:id "HP:0012198" ; a owl:Class ; rdfs:comment "A juvenile polyp is a hamartomatous growth that projects from the lining of the intestine. It does not arise from the colonocytes themselves but from the tissues underneath the lining cells." ; rdfs:label "Juvenile colonic polyposis" ; rdfs:subClassOf obo:HP_0004390, obo:HP_0030255 . obo:HP_0012199 obo:IAO_0000115 "A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T11:37:40Z" ; oboInOwl:hasDbXref "ICD-10:G44.0", "MSH:D003027", "SNOMEDCT_US:193031009", "SNOMEDCT_US:193947008", "SNOMEDCT_US:230473009", "UMLS:C0009088" ; oboInOwl:id "HP:0012199" ; a owl:Class ; rdfs:comment """According to the International Classification of Headache Disorders (ICHD-II), the diagnosis of cluster headache can be made with at least five attacks fulfilling criteria B-D: B) Severe or very severe unilateral orbital, supraorbital and/or temporal pain lasting 15-180 minutes if untreated. C) Headache is accompanied by at least 1 of the following: (i) Ipsilateral conjunctival injection and/or lacrimation. (ii) Ipsilateral nasal congestion and/or rhinorrhea. (iii) Ipsilateral eyelid edema. (iv) Ipsilateral forehead and facial sweating. (v) Ipsilateral miosis and/or ptosis. (vi) A sense of restlessness or agitation. D) Attacks have a frequency from 1 every other day to 8/day. Additionally, the headaches cannot attributed to another disorder.""" ; rdfs:label "Cluster headache" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0012200 obo:IAO_0000115 "An anomaly of clotting factor II, which is known as prothrombin, a vitamin K-dependent proenzyme that functions in the blood coagulation cascade." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T11:48:06Z" ; oboInOwl:hasDbXref "UMLS:C4023005" ; oboInOwl:id "HP:0012200" ; a owl:Class ; rdfs:label "Abnormality of prothrombin" ; rdfs:subClassOf obo:HP_0003256 . obo:HP_0012201 obo:IAO_0100001 "HP:0008151" ; oboInOwl:id "HP:0012201" ; a owl:Class ; rdfs:label "obsolete Reduced prothrombin activity" ; owl:deprecated true . obo:HP_0012202 obo:IAO_0000115 "An increase in the concentration of bile acid in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T11:56:40Z" ; oboInOwl:hasDbXref "UMLS:C4023004" ; oboInOwl:id "HP:0012202" ; a owl:Class ; rdfs:label "Increased serum bile acid concentration" ; rdfs:subClassOf obo:HP_0030984 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012203 obo:IAO_0000115 "A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:08:30Z" ; oboInOwl:hasDbXref "MSH:D014009", "SNOMEDCT_US:414941008", "UMLS:C0040261" ; oboInOwl:id "HP:0012203" ; a owl:Class ; rdfs:label "Onychomycosis" ; rdfs:subClassOf obo:HP_0002841 . obo:HP_0012204 obo:IAO_0000115 "Recurrent infection involving the vulva, vagina, and adjacent crural areas, whereby the causative agent belongs to the genus Candida." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:09:45Z" ; oboInOwl:hasDbXref "UMLS:C4023003" ; oboInOwl:id "HP:0012204" ; a owl:Class ; rdfs:label "Recurrent vulvovaginal candidiasis" ; rdfs:subClassOf obo:HP_0002728 . obo:HP_0012205 obo:IAO_0000115 "Any structural anomaly of the acrosome resulting in a round sperm head." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:21:08Z" ; oboInOwl:hasDbXref "MSH:D000072660", "SNOMEDCT_US:236818008", "UMLS:C0403825" ; oboInOwl:id "HP:0012205" ; a owl:Class ; rdfs:label "Globozoospermia" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0012206 obo:IAO_0000115 "An anomaly of the mobility of ejaculated sperm." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:23:21Z" ; oboInOwl:hasDbXref "UMLS:C0855512" ; oboInOwl:hasExactSynonym "Abnormal sperm motility", "Asthenospermia", "Asthenozoospermia" ; oboInOwl:id "HP:0012206" ; a owl:Class ; rdfs:label "Abnormal sperm motility" ; rdfs:subClassOf obo:HP_0034809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0097722 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012207 obo:IAO_0000115 "An abnormal reduction in the mobility of ejaculated sperm." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:23:59Z" ; oboInOwl:hasDbXref "UMLS:C4023002" ; oboInOwl:hasExactSynonym "Reduced sperm motility" ; oboInOwl:id "HP:0012207" ; a owl:Class ; rdfs:label "Reduced sperm motility" ; rdfs:subClassOf obo:HP_0012206 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0097722 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012208 obo:IAO_0000115 "A lack of mobility of ejaculated sperm." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:24:28Z" ; oboInOwl:hasDbXref "UMLS:C4023001" ; oboInOwl:hasExactSynonym "Nonmotile sperm" ; oboInOwl:id "HP:0012208" ; a owl:Class ; rdfs:label "Immotile sperm" ; rdfs:subClassOf obo:HP_0012206 . obo:HP_0012209 obo:IAO_0000115 "Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease of young childhood characterized clinically by overproduction of myelomonocytic cells and by the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor." ; dcterms:creator ; oboInOwl:creation_date "2013-03-12T12:27:41Z" ; oboInOwl:hasDbXref "MSH:D054429", "SNOMEDCT_US:128832006", "SNOMEDCT_US:277587001", "SNOMEDCT_US:445227008", "UMLS:C0349639" ; oboInOwl:hasExactSynonym "Juvenile myelomonocytic leukaemia" ; oboInOwl:id "HP:0012209" ; a owl:Class ; rdfs:label "Juvenile myelomonocytic leukemia" ; rdfs:subClassOf obo:HP_0012324 . obo:HP_0012210 obo:IAO_0000115 "Any structural anomaly of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T07:41:11Z" ; oboInOwl:hasAlternativeId "HP:0000792", "HP:0004726", "HP:0004735", "HP:0008712" ; oboInOwl:hasDbXref "Fyler:4512", "SNOMEDCT_US:44513007", "UMLS:C0266292" ; oboInOwl:hasExactSynonym "Abnormal kidney morphology", "Abnormally shaped kidney", "Kidney malformation", "Kidney structure issue", "Renal malformation", "Structural anomalies of the renal tract", "Structural kidney abnormalities", "Structural renal anomalies" ; oboInOwl:id "HP:0012210" ; a owl:Class ; rdfs:label "Abnormal renal morphology" ; rdfs:subClassOf obo:HP_0000077 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012211 obo:IAO_0000115 "An abnormal functionality of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T07:43:34Z" ; oboInOwl:hasAlternativeId "HP:0000082", "HP:0000087", "HP:0005566", "HP:0008646" ; oboInOwl:hasDbXref "SNOMEDCT_US:39539005", "UMLS:C0151746" ; oboInOwl:hasExactSynonym "Abnormal kidney function", "Abnormal renal function", "Abnormality of renal physiology", "Kidney function issue", "Renal functional abnormality" ; oboInOwl:id "HP:0012211" ; a owl:Class ; rdfs:label "Abnormal renal physiology" ; rdfs:subClassOf obo:HP_0000077, obo:HP_0011277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012212 obo:IAO_0000115 "An abnormally increased or reduced amount of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T07:49:53Z" ; oboInOwl:hasDbXref "UMLS:C0854050" ; oboInOwl:hasExactSynonym "Abnormal GFR" ; oboInOwl:id "HP:0012212" ; a owl:Class ; rdfs:comment "Glomerular filtration, the first step in urine formation, is the passive process of ultrafiltration of plasma from blood into Bowman's space as it traverses the glomerular capillaries. Because GFR varies by body size, it is indexed relative to an average body surface area (BSA) of 1.73 m2 and expressed as ml/min/per 1.73 m2. GFR cannot be measured directly; it can be assessed from clearance measurements or estimated from serum levels of endogenous filtration markers, such as creatinine or cystatin C. Clearance measurements require either multiple measurements of serum concentrations or timed urine collections and are not routinely performed. GFR is usually estimated from serum concentrations of a marker of filtration using GFR estimating equations." ; rdfs:label "Abnormal glomerular filtration rate" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0012213 obo:IAO_0000115 "An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T07:54:30Z" ; oboInOwl:hasAlternativeId "HP:0000120" ; oboInOwl:hasDbXref "UMLS:C0853068" ; oboInOwl:hasExactSynonym "Decreased GFR", "Impaired renal creatinine clearance", "Reduced creatinine clearance" ; oboInOwl:id "HP:0012213" ; a owl:Class ; rdfs:comment "Renal clearance is defined as the volume of plasma per minute needed to excrete the quantity of a solute appearing in the urine in a minute. Normal values for adults are 97 to 137 ml/min (male) and 88 to 128 ml/min (female). This term refers to a reduction below normal limits in the ability of the kidney to clear creatinine from the bloodstream." ; rdfs:label "Decreased glomerular filtration rate" ; rdfs:subClassOf obo:HP_0012212 . obo:HP_0012214 obo:IAO_0000115 "An abnormal rise in the volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T07:55:03Z" ; oboInOwl:hasDbXref "UMLS:C0856948" ; oboInOwl:hasExactSynonym "Increased GFR" ; oboInOwl:id "HP:0012214" ; a owl:Class ; rdfs:label "Increased glomerular filtration rate" ; rdfs:subClassOf obo:HP_0012212 . obo:HP_0012215 obo:IAO_0000115 "The deposition of calcium phosphate microliths within the seminiferous tubules." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T08:07:36Z" ; oboInOwl:hasDbXref "MSH:C566478", "SNOMEDCT_US:117261000119108", "UMLS:C1864873" ; oboInOwl:id "HP:0012215" ; a owl:Class ; rdfs:label "Testicular microlithiasis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0012216 obo:IAO_0000115 "An entrapment neuropathy of the suprascapular nerve, presenting with shoulder weakness confined to the supraspinatus muscle (this muscle initiates shoulder abduction) or to the infraspinatus (this muscle externally rotates the arm), as well as with pain in the posterior part of the shoulder and upper periscapular region." ; dcterms:creator ; oboInOwl:creation_date "2013-03-14T08:09:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:230635000", "UMLS:C0393890" ; oboInOwl:hasExactSynonym "Suprascapular nerve entrapment" ; oboInOwl:id "HP:0012216" ; a owl:Class ; rdfs:label "Entrapment neuropathy of suprascapular nerve" ; rdfs:subClassOf obo:HP_0012181 . obo:HP_0012217 obo:IAO_0000115 "The concentration of porphobilinogen in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T06:45:01Z" ; oboInOwl:hasDbXref "UMLS:C4023000" ; oboInOwl:id "HP:0012217" ; a owl:Class ; rdfs:comment "Increased porphobilinogen (PBG) in urine is pathognomonic of an attack of acute porphyria (acute intermittent porphyria, variegate porphyria, hereditary coproporphyria); the absence of increased urinary PBG in a suspected attack excludes the diagnosis." ; rdfs:label "Increased urinary porphobilinogen" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17381 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012218 obo:IAO_0000115 "A type of soft tissue sarcoma with a histological appearance reminiscent of alveoli because of its reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T06:48:50Z" ; oboInOwl:hasDbXref "MSH:D018234", "SNOMEDCT_US:404056007", "SNOMEDCT_US:88195001", "UMLS:C0206657" ; oboInOwl:id "HP:0012218" ; a owl:Class ; rdfs:label "Alveolar soft part sarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0012219 obo:IAO_0000115 "An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T06:57:07Z" ; oboInOwl:hasDbXref "MSH:D004893", "SNOMEDCT_US:32861005", "UMLS:C0014743" ; oboInOwl:id "HP:0012219" ; a owl:Class ; rdfs:comment "The nodules of erythema nodosum are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas, and usually subside in 3-6 weeks without scarring or atrophy." ; rdfs:label "Erythema nodosum" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0012220 obo:IAO_0000115 "The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese)." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:04:43Z" ; oboInOwl:hasDbXref "UMLS:C4022999" ; oboInOwl:id "HP:0012220" ; a owl:Class ; rdfs:comment "This feature is a hallmark of sarcoidosis." ; rdfs:label "Non-caseating epithelioid cell granulomatosis" ; rdfs:subClassOf obo:HP_0002955 . obo:HP_0012221 obo:IAO_0000115 "A type of blistering that affects the skin of the tibial region." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:10:17Z" ; oboInOwl:hasDbXref "MSH:C535494", "SNOMEDCT_US:67653003", "UMLS:C0432321" ; oboInOwl:hasExactSynonym "Pretibial epidermolysis bullosa" ; oboInOwl:id "HP:0012221" ; a owl:Class ; rdfs:label "Pretibial blistering" ; rdfs:subClassOf obo:HP_0033800 . obo:HP_0012222 obo:IAO_0000115 "The presence of multiple hemangiomas in the arachnoid." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:17:01Z" ; oboInOwl:hasDbXref "UMLS:C4022998" ; oboInOwl:id "HP:0012222" ; a owl:Class ; rdfs:label "Arachnoid hemangiomatosis" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0012223 obo:IAO_0000115 "A breach of the capsule of the spleen." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:23:49Z" ; oboInOwl:hasDbXref "MSH:D013161", "SNOMEDCT_US:234506007", "UMLS:C0038000" ; oboInOwl:hasExactSynonym "Ruptured spleen", "Splenic rupture" ; oboInOwl:id "HP:0012223" ; a owl:Class ; rdfs:label "Splenic rupture" ; rdfs:subClassOf obo:HP_0025408 . obo:HP_0012224 obo:IAO_0000115 "Persistence of immune complexes in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:27:21Z" ; oboInOwl:hasDbXref "UMLS:C3887628" ; oboInOwl:id "HP:0012224" ; a owl:Class ; rdfs:comment "Immune complexes are formed of interlocking antigens and antibodies and are normally are rapidly removed from the bloodstream by macrophages in the spleen and Kupffer cells in the liver. If they persist abnormally in the circulation, they may become trapped in various tissues and induce inflammatory reactions." ; rdfs:label "Circulating immune complexes" ; rdfs:subClassOf obo:HP_0005368 . obo:HP_0012225 obo:IAO_0000115 "Reduced number of primary teeth." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:31:16Z" ; oboInOwl:hasDbXref "UMLS:C4022997", "UMLS:C4280316" ; oboInOwl:hasExactSynonym "Failure of development of some deciduous teeth", "Failure of development of some primary teeth", "Partial anodontia of deciduous teeth", "Partial anodontia of primary teeth" ; oboInOwl:hasRelatedSynonym "Decreased number of baby teeth", "Decreased number of deciduous teeth", "Decreased number of milk teeth", "Decreased number of primary teeth", "Fewer baby teeth than normal", "Fewer deciduous teeth than normal", "Fewer primary teeth than normal", "Missing some baby teeth", "Missing some milk teeth", "Missing some primary teeth" ; oboInOwl:id "HP:0012225" ; a owl:Class ; rdfs:comment "Primary teeth are also called temporary teeth or deciduous teeth." ; rdfs:label "Oligodontia of primary teeth" ; rdfs:subClassOf obo:HP_0000677 . obo:HP_0012226 obo:IAO_0000115 "The presence of a teratoma in the ovary." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:34:29Z" ; oboInOwl:hasDbXref "NCIT:C3403", "SNOMEDCT_US:716077006", "UMLS:C0280131" ; oboInOwl:id "HP:0012226" ; a owl:Class ; rdfs:label "Ovarian teratoma" ; rdfs:subClassOf obo:HP_0009792, obo:HP_0100615 . obo:HP_0012227 obo:IAO_0000115 "Narrowing of the urethra associated with inflammation or scar tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:37:46Z" ; oboInOwl:hasDbXref "MSH:D014525", "SNOMEDCT_US:236647003", "SNOMEDCT_US:76618002", "UMLS:C0041974" ; oboInOwl:id "HP:0012227" ; a owl:Class ; rdfs:comment "A urethral stricture may result from surgery, disease, or injury. The term should not be used for a congenital narrowing of the urethra (Consider the term Urethral stenosis, HP:0008661)." ; rdfs:label "Urethral stricture" ; rdfs:subClassOf obo:HP_0008661 . obo:HP_0012228 obo:IAO_0000115 "A type of headache that last hours with continuous pain of mild or moderate intensity, bilateral location, a pressing/tightening (non-pulsating) quality and that is not aggravated by routine physical activity such as walking or climbing stairs." ; dcterms:creator ; oboInOwl:creation_date "2013-03-30T07:50:13Z" ; oboInOwl:hasDbXref "ICD-10:G44.2", "MSH:D018781", "SNOMEDCT_US:398057008", "SNOMEDCT_US:66551002", "UMLS:C0033893" ; oboInOwl:hasExactSynonym "Tension-type headache" ; oboInOwl:id "HP:0012228" ; a owl:Class ; rdfs:label "Tension-type headache" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0012229 obo:IAO_0000115 "An increased white blood cell count in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:01:55Z" ; oboInOwl:hasDbXref "MSH:D007964", "SNOMEDCT_US:91454002", "UMLS:C0151857" ; oboInOwl:hasExactSynonym "Cerebrospinal fluid pleocytosis", "Increased leukocyte count in CSF" ; oboInOwl:id "HP:0012229" ; a owl:Class ; rdfs:label "CSF pleocytosis" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0012230 obo:IAO_0000115 "A type of retinal detachment associated with a retinal tear, that is, with a break in the retina that allows fluid to pass from the vitreous space into the subretinal space between the sensory retina and the retinal pigment epithelium." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:20:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19620000", "UMLS:C0271055" ; oboInOwl:id "HP:0012230" ; a owl:Class ; rdfs:label "Rhegmatogenous retinal detachment" ; rdfs:subClassOf obo:HP_0000541 . obo:HP_0012231 obo:IAO_0000115 "A type of retinal detachment arising from damage to the outer blood-retinal barrier that allows fluid to access the subretinal space and separate the neurosensory retina from the retinal pigment epithelium." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:24:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:38599001", "UMLS:C0154822" ; oboInOwl:hasExactSynonym "Serous retinal detachment" ; oboInOwl:id "HP:0012231" ; a owl:Class ; rdfs:label "Exudative retinal detachment" ; rdfs:subClassOf obo:HP_0000541 . obo:HP_0012232 obo:IAO_0000115 "Decreased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG)." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:34:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77867006", "UMLS:C0151879" ; oboInOwl:id "HP:0012232" ; a owl:Class ; rdfs:label "Shortened QT interval" ; rdfs:subClassOf obo:HP_0031547 . obo:HP_0012233 obo:IAO_0000115 "Blood clot formed within muscle tissue following leakage of blood into the tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:38:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:262969000", "UMLS:C0240412" ; oboInOwl:hasExactSynonym "IM hematoma", "Intramuscular haematoma", "Intramuscular haemorrhage", "Intramuscular hemorrhage" ; oboInOwl:hasRelatedSynonym "Intramuscular hematomas" ; oboInOwl:id "HP:0012233" ; a owl:Class ; rdfs:label "Intramuscular hematoma" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0012234 obo:IAO_0000115 "Marked decrease in the number of granulocytes." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:42:50Z" ; oboInOwl:hasDbXref "UMLS:C0702094" ; oboInOwl:id "HP:0012234" ; a owl:Class ; rdfs:comment "Agranulocytosis is defined as an absolute neutrophil count less than 500 cells/microliter." ; rdfs:label "Agranulocytosis" ; rdfs:subClassOf obo:HP_0001913 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000094 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012235 obo:IAO_0000115 "A type of agranulocytosis related to ingestion of a specific medication." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:44:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:47318007", "UMLS:C0272178" ; oboInOwl:id "HP:0012235" ; a owl:Class ; rdfs:label "Drug-induced agranulocytosis" ; rdfs:subClassOf obo:HP_0012234 . obo:HP_0012236 obo:IAO_0000115 "An increased concentration of chloride in the sweat." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:50:28Z" ; oboInOwl:hasDbXref "UMLS:C1856646" ; oboInOwl:hasExactSynonym "Elevated sweat Cl", "Elevated sweat Cl-", "Elevated sweat chloride" ; oboInOwl:id "HP:0012236" ; a owl:Class ; rdfs:comment "Sweat chloride is notably increased in cystic fibrosis, but also in some other diseases." ; rdfs:label "Elevated sweat chloride" ; rdfs:subClassOf obo:HP_0040127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001089 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012237 obo:IAO_0000115 "An increased concentration of urocanic acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T09:54:48Z" ; oboInOwl:hasDbXref "MSH:C536479", "SNOMEDCT_US:60952007", "UMLS:C0268514" ; oboInOwl:hasExactSynonym "High urine urocanic acid levels" ; oboInOwl:id "HP:0012237" ; a owl:Class ; rdfs:label "Urocanic aciduria" ; rdfs:subClassOf obo:HP_0040156 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012238 obo:IAO_0000115 "Increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T04:17:11Z" ; oboInOwl:hasDbXref "UMLS:C1535978" ; oboInOwl:hasExactSynonym "Hyperchylomicronemia", "Increased chylomicrons", "Increased circulating chylomicron levels" ; oboInOwl:id "HP:0012238" ; a owl:Class ; rdfs:label "Increased circulating chylomicron concentration" ; rdfs:subClassOf obo:HP_0010980, obo:HP_0031887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042627 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012239 obo:IAO_0000115 "Absence of transferrin, a protein that transports iron, in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-03-31T04:20:43Z" ; oboInOwl:hasDbXref "MSH:C538259", "SNOMEDCT_US:111571009", "UMLS:C0521802" ; oboInOwl:id "HP:0012239" ; a owl:Class ; rdfs:label "Atransferrinemia" ; rdfs:subClassOf obo:HP_0032385 . obo:HP_0012240 obo:IAO_0000115 "An abnormal increase in intracellular lipid droplets In a muscle. The number and size of these drops can increase with somd disorders of lipid metabolism affecting muscle. See PMID 20691590 for histological images." ; dcterms:creator ; oboInOwl:creation_date "2013-04-01T05:17:37Z" ; oboInOwl:hasDbXref "UMLS:C4020730" ; oboInOwl:hasRelatedSynonym "Increased muscle lipid droplets" ; oboInOwl:id "HP:0012240" ; a owl:Class ; rdfs:comment "In normal muscle cells, lipid content takes the aspect of small droplets which concentration and size are usually higher in type 1 fibres than in type 2 fibres." ; rdfs:label "Increased intramyocellular lipid droplets" ; rdfs:subClassOf obo:HP_0009058 . obo:HP_0012241 obo:IAO_0000115 "Atrophy of the levator palpebrae superioris, the extraocular muscle that elevates the superior eyelid." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T06:53:20Z" ; oboInOwl:hasDbXref "UMLS:C1851107" ; oboInOwl:id "HP:0012241" ; a owl:Class ; rdfs:label "Levator palpebrae superioris atrophy" ; rdfs:subClassOf obo:HP_0011805, obo:HP_3000072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012242 obo:IAO_0000115 "Atrophy of the superior rectus, the extraocular muscle whose primary function is to elevate the globe." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T06:55:22Z" ; oboInOwl:hasDbXref "UMLS:C1851108" ; oboInOwl:hasExactSynonym "Rectus superior atrophy" ; oboInOwl:id "HP:0012242" ; a owl:Class ; rdfs:label "Superior rectus atrophy" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006533 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012243 obo:IAO_0000115 "A structural or developmental anomaly of any of the tissues involved in the genital system." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T07:02:20Z" ; oboInOwl:hasDbXref "UMLS:C4021096" ; oboInOwl:hasExactSynonym "Abnormal genital system morphology" ; oboInOwl:id "HP:0012243" ; a owl:Class ; rdfs:label "Abnormal reproductive system morphology" ; rdfs:subClassOf obo:HP_0000078 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012244 obo:IAO_0000115 "Anomaly of primary or secondary sexual development or characteristics." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T07:03:45Z" ; oboInOwl:hasDbXref "UMLS:C4022996" ; oboInOwl:id "HP:0012244" ; a owl:Class ; rdfs:label "Abnormal sex determination" ; rdfs:subClassOf obo:HP_0012243 . obo:HP_0012245 obo:IAO_0000115 "Development of the reproductive system is inconsistent with the chromosomal sex." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T07:04:44Z" ; oboInOwl:hasDbXref "UMLS:C4022995" ; oboInOwl:id "HP:0012245" ; a owl:Class ; rdfs:comment "Sex reversal is present if an XX individual develops phenotypically as a male or if an XY individual develops as a female." ; rdfs:label "Sex reversal" ; rdfs:subClassOf obo:HP_0012244 . obo:HP_0012246 obo:IAO_0000115 "Reduced ability to control the movement of the eye associated with damage to the third cranial nerve (the oculomotor nerve)." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T07:15:18Z" ; oboInOwl:hasDbXref "MSH:D015840", "SNOMEDCT_US:388980004", "UMLS:C0028866" ; oboInOwl:hasRelatedSynonym "Oculomotor neuropathy" ; oboInOwl:id "HP:0012246" ; a owl:Class ; rdfs:label "Oculomotor nerve palsy" ; rdfs:subClassOf obo:HP_0000597, obo:HP_0006824 . obo:HP_0012247 obo:IAO_0000115 "Anosmia for one particular odor." ; dcterms:creator ; oboInOwl:creation_date "2013-04-02T07:20:11Z" ; oboInOwl:hasDbXref "UMLS:C4022994" ; oboInOwl:id "HP:0012247" ; a owl:Class ; rdfs:label "Specific anosmia" ; rdfs:subClassOf obo:HP_0000458 . obo:HP_0012248 obo:IAO_0000115 "Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex)." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T08:52:29Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:164947007", "UMLS:C0600125" ; oboInOwl:hasExactSynonym "Electrocardiographic long PR interval", "Lengthened PR interval on EKG" ; oboInOwl:id "HP:0012248" ; a owl:Class ; rdfs:comment "In adults, normal values are 120 to 200 ms long." ; rdfs:label "Prolonged PR interval" ; rdfs:subClassOf obo:HP_0031593 . obo:HP_0012249 obo:IAO_0000115 "An electrocardiographic anomaly of the ST segment, which is the segment that connects the QRS complex and the T wave. The ST segment normally has a duration of 80 to 120 ms, is flat and at the same level (isoelectric) as the PR and TP segment." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T08:56:46Z" ; oboInOwl:hasDbXref "UMLS:C4022993" ; oboInOwl:id "HP:0012249" ; a owl:Class ; rdfs:label "Abnormal ST segment" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0012250 obo:IAO_0000115 "An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T08:59:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:26141007", "SNOMEDCT_US:429622005", "UMLS:C0520887" ; oboInOwl:id "HP:0012250" ; a owl:Class ; rdfs:label "ST segment depression" ; rdfs:subClassOf obo:HP_0012249 . obo:HP_0012251 obo:IAO_0000115 "An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:03:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:164931005", "SNOMEDCT_US:76388001", "UMLS:C0520886" ; oboInOwl:id "HP:0012251" ; a owl:Class ; rdfs:comment "ST segment elevation may have multiple causes including myocardial infaction, left ventricular aneurysm, and hyperkalemia." ; rdfs:label "ST segment elevation" ; rdfs:subClassOf obo:HP_0012249 . obo:HP_0012252 obo:IAO_0000115 "A structural anomaly of the respiratory system." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:11:09Z" ; oboInOwl:hasDbXref "Fyler:4235", "UMLS:C4022992" ; oboInOwl:id "HP:0012252" ; a owl:Class ; rdfs:label "Abnormal respiratory system morphology" ; rdfs:subClassOf obo:HP_0002086 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012253 obo:IAO_0000115 "Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:12:48Z" ; oboInOwl:hasDbXref "UMLS:C4022991" ; oboInOwl:id "HP:0012253" ; a owl:Class ; rdfs:label "Abnormal respiratory epithelium morphology" ; rdfs:subClassOf obo:HP_0012252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012254 obo:IAO_0000115 "A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T01:54:14Z" ; oboInOwl:hasDbXref "MSH:D012512", "SNOMEDCT_US:76909002", "UMLS:C0553580" ; oboInOwl:hasExactSynonym "Ewing's sarcoma" ; oboInOwl:id "HP:0012254" ; a owl:Class ; rdfs:comment "Histologically, Ewing's sarcoma is composed of a homogeneous population of small round cells with high nuclear to cytoplasmic ratios that are arrayed in sheets. There is scant cytoplasms, which is pale, vacuolated and characterized by faded boundaries. In contrast, the nuclei are clearly visualized by their intense color. Mitotic activity is typically low." ; rdfs:label "Ewing sarcoma" ; rdfs:subClassOf obo:HP_0100242 . obo:HP_0012255 obo:IAO_0000115 "An anomaly of the dynein arms of motile cilia. This feature is usually appreciated by electron microscopy." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:20:03Z" ; oboInOwl:hasDbXref "UMLS:C4022990" ; oboInOwl:id "HP:0012255" ; a owl:Class ; rdfs:comment "The peripheral microtubules in the canonical 9 + 2 microtubular pattern of motile cilia are studded with dynein arms that contain adenosine triphosphatases and act as molecular motors to effect the sliding of the peripheral microtubular pairs relative to one another." ; rdfs:label "Dynein arm defect of respiratory motile cilia" ; rdfs:subClassOf obo:HP_0005938 . obo:HP_0012256 obo:IAO_0000115 "Absence of the outer dynein arms of respiratory motile cilia, which normally are situated outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:35:55Z" ; oboInOwl:hasDbXref "UMLS:C4022989" ; oboInOwl:id "HP:0012256" ; a owl:Class ; rdfs:label "Absent outer dynein arms" ; rdfs:subClassOf obo:HP_0200106 . obo:HP_0012257 obo:IAO_0000115 "Absence of the inner dynein arms of respiratory motile cilia, which normally are situated within the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:38:46Z" ; oboInOwl:hasDbXref "UMLS:C4022988" ; oboInOwl:id "HP:0012257" ; a owl:Class ; rdfs:label "Absent inner dynein arms" ; rdfs:subClassOf obo:HP_0200106 . obo:HP_0012258 obo:IAO_0000115 "Abnormal arrangement of the structures of the axoneme, which is the cytoskeletal structure that forms the inner core of the motile cilium and displays a canonical 9+2 microtubular pattern of motile cilia studded with dynein arms." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:49:56Z" ; oboInOwl:hasDbXref "UMLS:C4022987" ; oboInOwl:hasExactSynonym "Abnormal axonemal organisation of respiratory motile cilia" ; oboInOwl:id "HP:0012258" ; a owl:Class ; rdfs:comment "Abnormal axonemal organization comprises anomalies such as an eccentric central pair of microtubuli, abnormal radial spokes and nexin links, reduced number of inner dynein arms, and displacement of the outer doublet." ; rdfs:label "Abnormal axonemal organization of respiratory motile cilia" ; rdfs:subClassOf obo:HP_0005938 . obo:HP_0012259 obo:IAO_0000115 "Complete absence of the dynein arms of respiratory motile cilia, that is, absence of the inner and the outer dynein arms, which normally are situated inside and outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:40:14Z" ; oboInOwl:hasDbXref "UMLS:C4022986" ; oboInOwl:id "HP:0012259" ; a owl:Class ; rdfs:label "Absent inner and outer dynein arms" ; rdfs:subClassOf obo:HP_0012256, obo:HP_0012257 . obo:HP_0012260 obo:IAO_0000115 "A structural anomaly of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T09:58:27Z" ; oboInOwl:hasDbXref "UMLS:C4022985" ; oboInOwl:id "HP:0012260" ; a owl:Class ; rdfs:comment "The central microtubular pair is referred to as the central part of axoneme of cilium." ; rdfs:label "Abnormal central microtubular pair morphology of respiratory motile cilia" ; rdfs:subClassOf obo:HP_0005938 . obo:HP_0012261 obo:IAO_0000115 "Any functional anomaly of the respiratory motile cilia." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:05:43Z" ; oboInOwl:hasDbXref "UMLS:C4022984" ; oboInOwl:id "HP:0012261" ; a owl:Class ; rdfs:comment "Abnormal respiratory motile cilium physiology may include alterations in ciliary beating pattern or frequency." ; rdfs:label "Abnormal respiratory motile cilium physiology" ; rdfs:subClassOf obo:HP_0002795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0002368 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0031514 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012262 obo:IAO_0000115 "Any anomaly of the normal motility of motile cilia. Evaluation of ciliary beat frequency and ciliary beat pattern requires high-speed videomicroscopy of freshly obtained ciliary biopsies that are maintained in culture media under controlled conditions." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:10:35Z" ; oboInOwl:hasDbXref "UMLS:C4022983" ; oboInOwl:id "HP:0012262" ; a owl:Class ; rdfs:comment "Ciliated epithelial cells bear approximately 200 motile (9 + 2) cilia that move with both intracellular and intercellular synchrony. The pattern of beat in 9 + 2 motile cilia occurs in a waveform having a forward effective stroke followed by a return stroke. The direction of stroke is a function of the directional orientation of the central microtubules. In addition to moving in synchrony, individual cilia in normal cells are very plastic and move fluidly, sometimes deforming briefly upon encountering resistance and/or particles being transported over the mucosal surface. Cilia are embedded in a watery periciliary fluid of low viscosity, which facilitates the rapid beat cycle to move the more viscous overlying layer of mucus. Ciliary beat frequency ranges from approximately 8-20 Hz under normal conditions but may be accelerated by exposure to irritants such as tobacco smoke." ; rdfs:label "Abnormal ciliary motility" ; rdfs:subClassOf obo:HP_0012261 . obo:HP_0012263 dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:11:17Z" ; oboInOwl:hasDbXref "UMLS:C1855672" ; oboInOwl:id "HP:0012263" ; a owl:Class ; rdfs:label "Immotile cilia" ; rdfs:subClassOf obo:HP_0012262 . obo:HP_0012264 obo:IAO_0000115 "Absence of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:12:06Z" ; oboInOwl:hasDbXref "UMLS:C4022982" ; oboInOwl:id "HP:0012264" ; a owl:Class ; rdfs:label "Absent central microtubular pair morphology of respiratory motile cilia" ; rdfs:subClassOf obo:HP_0005938 . obo:HP_0012265 obo:IAO_0000115 "A deviation from the normally well coordinated pattern of intracellular and intercellular synchrony of motile cilia. Dyskinetic cilia usually beat out of synchrony relative to neighboring cilia." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:14:07Z" ; oboInOwl:hasDbXref "MSH:D002925", "SNOMEDCT_US:86204009", "UMLS:C0008780" ; oboInOwl:hasExactSynonym "Lack of coordinated beating of respiratory cilia" ; oboInOwl:id "HP:0012265" ; a owl:Class ; rdfs:comment "Typically, but not always, dyskinesia is characterized by markedly attenuated ciliary beat frequency." ; rdfs:label "Ciliary dyskinesia" ; rdfs:subClassOf obo:HP_0012262 . obo:HP_0012266 obo:IAO_0000115 "A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:23:08Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:428550008", "UMLS:C1998313" ; oboInOwl:id "HP:0012266" ; a owl:Class ; rdfs:label "T-wave alternans" ; rdfs:subClassOf obo:HP_0005135 . obo:HP_0012267 obo:IAO_0000115 "Absence of the radial spokes of the axoneme of the respiratory cilium." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T01:56:53Z" ; oboInOwl:hasDbXref "UMLS:C4022981" ; oboInOwl:id "HP:0012267" ; a owl:Class ; rdfs:label "Absent respiratory ciliary axoneme radial spokes" ; rdfs:subClassOf obo:HP_0005938 . obo:HP_0012268 obo:IAO_0000115 "A liposarcoma that contains myxomatous tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T01:59:19Z" ; oboInOwl:hasDbXref "MSH:D018208", "SNOMEDCT_US:27849002", "SNOMEDCT_US:404069006", "UMLS:C0206634" ; oboInOwl:id "HP:0012268" ; a owl:Class ; rdfs:label "Myxoid liposarcoma" ; rdfs:subClassOf obo:HP_0012034 . obo:HP_0012269 obo:IAO_0000115 "Any anomaly in the amount of glycogen in muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:04:03Z" ; oboInOwl:hasDbXref "UMLS:C4022980" ; oboInOwl:id "HP:0012269" ; a owl:Class ; rdfs:comment "Glycogen functions as a secondary short term energy storage in muscle." ; rdfs:label "Abnormal muscle glycogen content" ; rdfs:subClassOf obo:HP_0034370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012270 obo:IAO_0000115 "A decreased amount of glycogen in muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:05:15Z" ; oboInOwl:hasDbXref "UMLS:C4022979" ; oboInOwl:id "HP:0012270" ; a owl:Class ; rdfs:label "Decreased muscle glycogen content" ; rdfs:subClassOf obo:HP_0012269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012271 obo:IAO_0000115 "Intermittent episodes of increased resistance to the passage of air in the upper airway." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:08:33Z" ; oboInOwl:hasDbXref "UMLS:C4022978" ; oboInOwl:id "HP:0012271" ; a owl:Class ; rdfs:label "Episodic upper airway obstruction" ; rdfs:subClassOf obo:HP_0002781 . obo:HP_0012272 obo:IAO_0000115 "The J wave is a positive convex deflection that occurs at the junction of the QRS complex and ST segment, the J-point." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:11:05Z" ; oboInOwl:hasDbXref "UMLS:C4018858" ; oboInOwl:hasExactSynonym "EKG J waves", "Osborne waves" ; oboInOwl:id "HP:0012272" ; a owl:Class ; rdfs:comment "J waves can be seen in hypothermia when the core body temperature falls below 32 degrees C. Then, they occur most prominently in the inferior leads: II, III, and aVF and the precordial leads: V5-V6. J waves can also be observed in other conditions such as some forms of Brugada syndrome." ; rdfs:label "J wave" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0012273 obo:IAO_0000115 "An increase in the combined thickness of the intima and media of the carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:16:23Z" ; oboInOwl:hasDbXref "UMLS:C4022977" ; oboInOwl:id "HP:0012273" ; a owl:Class ; rdfs:comment "This feature can be measured by ultrasonography and is thought to be a risk foctor for myocardial infarction and stroke." ; rdfs:label "Increased carotid artery intimal medial thickness" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0012274 obo:IAO_0000115 "A type of autosomal dominant inheritance involving a gene that is imprinted with paternal silencing." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:19:07Z" ; oboInOwl:hasDbXref "UMLS:C4022976" ; oboInOwl:id "HP:0012274" ; a owl:Class ; rdfs:comment "Since the paternally inherited copy of such genes is silenced normally, only a maternally transmitted mutation leads to disease in this kind of inheritance." ; rdfs:label "Autosomal dominant inheritance with paternal imprinting" ; rdfs:subClassOf obo:HP_0034338 . obo:HP_0012275 obo:IAO_0000115 "A type of autosomal dominant inheritance involving a gene that is imprinted with maternal silencing." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T02:54:09Z" ; oboInOwl:hasDbXref "UMLS:C4022975" ; oboInOwl:id "HP:0012275" ; a owl:Class ; rdfs:comment "Since the maternally inherited copy of such genes is silenced normally, only a paternally transmitted mutation leads to disease in this kind of inheritance." ; rdfs:label "Autosomal dominant inheritance with maternal imprinting" ; rdfs:subClassOf obo:HP_0034338 . obo:HP_0012276 obo:IAO_0000115 "Inflammation of the flexor digitorum tendon, often associated with the Kanavel signs: (i) finger held in slight flexion, (ii) fusiform swelling, (iii) tenderness along the flexor tendon sheath, and (iv) pain with passive extension of the digit." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T03:02:33Z" ; oboInOwl:hasDbXref "UMLS:C4022974" ; oboInOwl:hasExactSynonym "Trigger finger" ; oboInOwl:id "HP:0012276" ; a owl:Class ; rdfs:comment "Tenosynovitis refers to inflammation of the protective sheath that surrounds a tendon. Stenosing tenosynovitis, or trigger finger, is diagnosed when a patient presents with a symptomatic locking or clicking of a finger or the thumb. It is caused by a mismatch between the volume of the flexor tendon sheath and its contents. As the flexor tendon attempts to glide through a relatively stenotic sheath, it catches, producing an inability to flex or extend the digit smoothly." ; rdfs:label "Digital flexor tenosynovitis" ; rdfs:subClassOf obo:HP_0100261 . obo:HP_0012277 obo:IAO_0000115 "An abnormally reduced concentration of glycine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T03:54:41Z" ; oboInOwl:hasDbXref "UMLS:C4022973" ; oboInOwl:hasExactSynonym "Low blood glycine levels" ; oboInOwl:id "HP:0012277" ; a owl:Class ; rdfs:label "Hypoglycinemia" ; rdfs:subClassOf obo:HP_0010895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15428 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012278 obo:IAO_0000115 "Any deviation from the normal concentration of serine in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T03:57:10Z" ; oboInOwl:hasDbXref "UMLS:C4022972" ; oboInOwl:id "HP:0012278" ; a owl:Class ; rdfs:label "Abnormal circulating serine concentration" ; rdfs:subClassOf obo:HP_0010894 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006563 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012279 obo:IAO_0000115 "Reduced concentration of serine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T03:57:25Z" ; oboInOwl:hasDbXref "UMLS:C4022971" ; oboInOwl:hasExactSynonym "Low blood serine levels" ; oboInOwl:id "HP:0012279" ; a owl:Class ; rdfs:label "Hyposerinemia" ; rdfs:subClassOf obo:HP_0012278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17822 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012280 obo:IAO_0000115 "A form of amyloidosis that affects the liver." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T03:59:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:9551004", "UMLS:C0267839" ; oboInOwl:id "HP:0012280" ; a owl:Class ; rdfs:label "Hepatic amyloidosis" ; rdfs:subClassOf obo:HP_0011034, obo:HP_0410042 . obo:HP_0012281 obo:IAO_0000115 "Extravasation of chyle into the peritoneal cavity." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T04:08:42Z" ; oboInOwl:hasDbXref "MSH:D002915", "SNOMEDCT_US:52985009", "UMLS:C0008732" ; oboInOwl:hasExactSynonym "Chyloperitoneum" ; oboInOwl:id "HP:0012281" ; a owl:Class ; rdfs:label "Chylous ascites" ; rdfs:subClassOf obo:HP_0001541 . obo:HP_0012282 obo:IAO_0000115 "An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days." ; dcterms:creator ; oboInOwl:creation_date "2013-04-07T10:11:58Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:247470007", "SNOMEDCT_US:50495000", "UMLS:C0234918" ; oboInOwl:id "HP:0012282" ; a owl:Class ; rdfs:comment "A morbilliform rash is said to resemble the rash of measles, rubella or scarlet fever, thus mimicking viral and bacterial exanthemas." ; rdfs:label "Morbilliform rash" ; rdfs:subClassOf obo:HP_4000054 . obo:HP_0012283 obo:IAO_0000115 "Reduced size of the Distal epiphysis of femur." ; dcterms:creator ; oboInOwl:creation_date "2013-04-09T07:33:19Z" ; oboInOwl:hasDbXref "UMLS:C4022970" ; oboInOwl:hasExactSynonym "Small end part of outermost thighbone" ; oboInOwl:id "HP:0012283" ; a owl:Class ; rdfs:label "Small distal femoral epiphysis" ; rdfs:subClassOf obo:HP_0010590 . obo:HP_0012284 obo:IAO_0000115 "Reduced size of the proximal epiphysis of the tibia." ; dcterms:creator ; oboInOwl:creation_date "2013-04-09T07:36:38Z" ; oboInOwl:hasDbXref "UMLS:C4022969" ; oboInOwl:hasExactSynonym "Small end part of innermost shankbone", "Small end part of innermost shinbone" ; oboInOwl:id "HP:0012284" ; a owl:Class ; rdfs:label "Small proximal tibial epiphyses" ; rdfs:subClassOf obo:HP_0010585, obo:HP_0010591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008772 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012285 obo:IAO_0000115 "An abnormal functionality of the hypothalamus." ; dcterms:creator ; oboInOwl:creation_date "2013-04-09T07:51:07Z" ; oboInOwl:hasDbXref "UMLS:C4022968" ; oboInOwl:id "HP:0012285" ; a owl:Class ; rdfs:comment "The hypothalamus is linked vascularly with the anterior lobe of the pituitary gland and thereby controls the secretion of pituitary hormones." ; rdfs:label "Abnormal hypothalamus physiology" ; rdfs:subClassOf obo:HP_0000864, obo:HP_0010662, obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012286 obo:IAO_0000115 "Any structural anomaly of the hypothalamus." ; dcterms:creator ; oboInOwl:creation_date "2013-04-09T07:53:16Z" ; oboInOwl:hasAlternativeId "HP:0002443" ; oboInOwl:hasDbXref "UMLS:C4021095" ; oboInOwl:hasExactSynonym "Abnormal shape of hypothalamus", "Abnormality of hypothalamus morphology", "Abnormality of the hypothalamus" ; oboInOwl:id "HP:0012286" ; a owl:Class ; rdfs:comment "The hypothalamus is a cone-shaped cerebral structure that projects downward, ending in the pituitary (infundibular) stalk, a tubular connection to the pituitary gland. It is linked vascularly with the anterior lobe of the pituitary gland and thereby controls the secretion of pituitary hormones." ; rdfs:label "Abnormal hypothalamus morphology" ; rdfs:subClassOf obo:HP_0010662 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012287 obo:IAO_0000115 "Decreased secretion of luteinizing hormone-releasing hormone by the hypothalamus." ; dcterms:creator ; oboInOwl:creation_date "2013-04-09T07:54:46Z" ; oboInOwl:hasDbXref "UMLS:C4022967" ; oboInOwl:id "HP:0012287" ; a owl:Class ; rdfs:label "Hypothalamic luteinizing hormone-releasing hormone deficiency" ; rdfs:subClassOf obo:HP_0012285 . obo:HP_0012288 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx." ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T05:44:24Z" ; oboInOwl:hasDbXref "MSH:D006258", "SNOMEDCT_US:255055008", "SNOMEDCT_US:255056009", "UMLS:C0018671", "UMLS:C0278996" ; oboInOwl:hasExactSynonym "Head and neck tumor", "Head and neck tumour" ; oboInOwl:hasRelatedSynonym "Head and neck cancer" ; oboInOwl:id "HP:0012288" ; a owl:Class ; rdfs:label "Neoplasm of head and neck" ; rdfs:subClassOf obo:HP_0011793 . obo:HP_0012289 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the face." ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T05:46:35Z" ; oboInOwl:hasDbXref "MSH:D005153", "NCIT:C3262", "SNOMEDCT_US:126632002", "UMLS:C0015461" ; oboInOwl:hasExactSynonym "Face tumor", "Face tumour" ; oboInOwl:id "HP:0012289" ; a owl:Class ; rdfs:label "Facial neoplasm" ; rdfs:subClassOf obo:HP_0012288 . obo:HP_0012290 obo:IAO_0100001 "HP:0100649" ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T05:48:12Z" ; oboInOwl:id "HP:0012290" ; a owl:Class ; rdfs:label "obsolete Mouth neoplasm" ; owl:deprecated true . obo:HP_0012291 obo:IAO_0100001 "HP:0100551" ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T05:49:21Z" ; oboInOwl:id "HP:0012291" ; a owl:Class ; rdfs:label "obsolete Tracheal neoplasm" ; owl:deprecated true . obo:HP_0012292 obo:IAO_0000115 "A congenital defect with an abnormal joining of the gums of the upper and lower jaw." ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T05:52:35Z" ; oboInOwl:hasDbXref "UMLS:C4022966" ; oboInOwl:hasExactSynonym "Fusion of gums", "Fusion of the gingiva", "Gingival synechia", "Partial fusion of the gums", "Synechia of the gums", "Upper and lower gums fused together" ; oboInOwl:id "HP:0012292" ; a owl:Class ; rdfs:label "Fusion of gums" ; rdfs:subClassOf obo:HP_0000168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0011602 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012293 obo:IAO_0000115 "An abnormal pigmentation pattern of the external genitalia." ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T06:02:08Z" ; oboInOwl:hasDbXref "UMLS:C4022965" ; oboInOwl:id "HP:0012293" ; a owl:Class ; rdfs:label "Abnormal genital pigmentation" ; rdfs:subClassOf obo:HP_0000811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004176 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012294 obo:IAO_0000115 "Abnormality of the occipital bone of the skull." ; dcterms:creator ; oboInOwl:creation_date "2013-04-11T06:21:12Z" ; oboInOwl:hasDbXref "UMLS:C4022964" ; oboInOwl:hasExactSynonym "Abnormality of the occipital bone" ; oboInOwl:id "HP:0012294" ; a owl:Class ; rdfs:label "Abnormal occipital bone morphology" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012295 obo:IAO_0000115 "Reduced diameter of the middle phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2013-04-12T05:40:22Z" ; oboInOwl:hasDbXref "UMLS:C4022963" ; oboInOwl:hasExactSynonym "Slender middle bone of finger" ; oboInOwl:id "HP:0012295" ; a owl:Class ; rdfs:label "Slender middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012296 obo:IAO_0000115 "Reduced diameter of the distal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2013-04-12T05:42:46Z" ; oboInOwl:hasDbXref "UMLS:C4022962" ; oboInOwl:hasExactSynonym "Slender outermost bone of finger" ; oboInOwl:id "HP:0012296" ; a owl:Class ; rdfs:label "Slender distal phalanx of finger" ; rdfs:subClassOf obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012297 obo:IAO_0000115 "Reduced diameter of the proximal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2013-04-12T05:45:35Z" ; oboInOwl:hasDbXref "UMLS:C4022961" ; oboInOwl:hasExactSynonym "Slender innermost bone of finger" ; oboInOwl:id "HP:0012297" ; a owl:Class ; rdfs:label "Slender proximal phalanx of finger" ; rdfs:subClassOf obo:HP_0009834 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012298 obo:IAO_0000115 "Increased length of the middle phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2013-04-12T05:46:43Z" ; oboInOwl:hasDbXref "UMLS:C4022960" ; oboInOwl:hasExactSynonym "Long middle bone of finger" ; oboInOwl:id "HP:0012298" ; a owl:Class ; rdfs:label "Long middle phalanx of finger" ; rdfs:subClassOf obo:HP_0009833 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012299 obo:IAO_0000115 "Increased length of the distal phalanx of finger." ; dcterms:creator ; oboInOwl:creation_date "2013-04-12T05:48:52Z" ; oboInOwl:hasDbXref "UMLS:C4021865" ; oboInOwl:hasExactSynonym "Long outermost bone of finger" ; oboInOwl:id "HP:0012299" ; a owl:Class ; rdfs:label "Long distal phalanx of finger" ; rdfs:subClassOf obo:HP_0009832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012300 obo:IAO_0000115 "Failure of the ureter to undergo development." ; dcterms:creator ; oboInOwl:creation_date "2013-04-13T06:00:10Z" ; oboInOwl:hasDbXref "UMLS:C4022959" ; oboInOwl:id "HP:0012300" ; a owl:Class ; rdfs:label "Ureteral agenesis" ; rdfs:subClassOf obo:HP_0025633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012301 obo:IAO_0000115 "Abnormal transferrin isoform profile consistent with a type II congenital disorder of glycosylation." ; dcterms:creator ; oboInOwl:creation_date "2013-04-14T08:55:20Z" ; oboInOwl:hasDbXref "UMLS:C4021094" ; oboInOwl:hasExactSynonym "Abnormal isoelectric focusing of serum transferrin, type II pattern", "Isoelectric focusing of serum transferrin consistent with CDG type II", "Type 2 transferrin isoform profile" ; oboInOwl:hasRelatedSynonym "Abnormal isoelectric focusing of serum transferrin, type 2 pattern" ; oboInOwl:id "HP:0012301" ; a owl:Class ; rdfs:comment "There are several methods in use with which this feature can be diagnosed. Using HPLC analysis increased mono- and trisialotransferrin and reduced tetrasialotransferrin are observed. Using immunoaffinity column analysis, the tri-sialo/di-oligosaccharide transferrin ratio is abnormal." ; rdfs:label "Type II transferrin isoform profile" ; rdfs:subClassOf obo:HP_0003160 . obo:HP_0012302 obo:IAO_0000115 "Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction." ; dcterms:creator ; oboInOwl:creation_date "2013-04-14T02:43:10Z" ; oboInOwl:hasAlternativeId "HP:0020098" ; oboInOwl:hasDbXref "MSH:D020803", "SNOMEDCT_US:428638009", "UMLS:C0276226" ; oboInOwl:hasExactSynonym "Herpes encephalitis" ; oboInOwl:id "HP:0012302" ; a owl:Class ; rdfs:comment "Although infection with HSV is very common in the population, only a miniscule proportion of infected persons develop encephalitis, so that an occurrence of HSV encephalitis is interpreted as a sign of increased susceptibility to HSV. Herpes encephalitis may occur in immunocompromised patients, but HSV-1 is consistently the single most common cause of sporadic encephalitis worldwide." ; rdfs:label "Herpes simplex encephalitis" ; rdfs:subClassOf obo:HP_0033993 . obo:HP_0012303 obo:IAO_0000115 "An anomaly of the arch of aorta." ; dcterms:creator ; oboInOwl:creation_date "2013-08-06T10:06:07Z" ; oboInOwl:hasDbXref "Fyler:2700", "SNOMEDCT_US:448742006", "UMLS:C3163801" ; oboInOwl:hasExactSynonym "Abnormality of the aortic arch" ; oboInOwl:id "HP:0012303" ; a owl:Class ; rdfs:label "Abnormal aortic arch morphology" ; rdfs:subClassOf obo:HP_0001679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001508 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012304 obo:IAO_0000115 "Underdevelopment of the arch of aorta." ; dcterms:creator ; oboInOwl:creation_date "2013-08-06T10:10:36Z" ; oboInOwl:hasDbXref "Fyler:2704", "SNOMEDCT_US:60787001", "UMLS:C0265881" ; oboInOwl:hasExactSynonym "Aortic arch hypoplasia", "Underdeveloped aortic arch" ; oboInOwl:id "HP:0012304" ; a owl:Class ; rdfs:label "Hypoplastic aortic arch" ; rdfs:subClassOf obo:HP_0012303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001508 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012305 obo:IAO_0000115 "Narrowing or constriction of the aorta localized to the region of the descending trunk of arch of aorta." ; dcterms:creator ; oboInOwl:creation_date "2013-08-06T10:34:15Z" ; oboInOwl:hasDbXref "UMLS:C4022958" ; oboInOwl:id "HP:0012305" ; a owl:Class ; rdfs:label "Coarctation of the descending aortic arch" ; rdfs:subClassOf obo:HP_0001680, obo:HP_0012303 . obo:HP_0012306 obo:IAO_0000115 "An anomaly of the process of rib bone formation." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T09:31:03Z" ; oboInOwl:hasDbXref "UMLS:C4022957" ; oboInOwl:hasRelatedSynonym "Abnormal maturation of rib bones" ; oboInOwl:id "HP:0012306" ; a owl:Class ; rdfs:label "Abnormal rib ossification" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002228 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012307 obo:IAO_0000115 "Ribs that are increased in width and taper to the posterior ends." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T10:15:15Z" ; oboInOwl:hasDbXref "UMLS:C1856637" ; oboInOwl:id "HP:0012307" ; a owl:Class ; rdfs:comment "This morphological anomaly of the rib has been compared to a canoe panel or a spatula, whence the name." ; rdfs:label "Spatulate ribs" ; rdfs:subClassOf obo:HP_0000885 . obo:HP_0012308 obo:IAO_0000115 "Concentration of the complement component C9 in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T11:07:25Z" ; oboInOwl:hasDbXref "UMLS:C4021093" ; oboInOwl:hasExactSynonym "Decreased serum C9", "Decreased serum complement C9" ; oboInOwl:id "HP:0012308" ; a owl:Class ; rdfs:label "Decreased circulating complement C9 concentration" ; rdfs:subClassOf obo:HP_0033057 . obo:HP_0012309 obo:IAO_0000115 "The presence of amyloid deposition in the superficial dermis." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T11:59:57Z" ; oboInOwl:hasDbXref "MSH:C562642", "SNOMEDCT_US:201337008", "SNOMEDCT_US:281882003", "SNOMEDCT_US:282834007", "SNOMEDCT_US:718105008", "UMLS:C0268397" ; oboInOwl:id "HP:0012309" ; a owl:Class ; rdfs:label "Cutaneous amyloidosis" ; rdfs:subClassOf obo:HP_0011034 . obo:HP_0012310 obo:IAO_0000115 "An anomaly in the number of monocytes, which are myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:07:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165540007", "SNOMEDCT_US:165541006", "UMLS:C0580319" ; oboInOwl:hasExactSynonym "Abnormal monocyte number" ; oboInOwl:id "HP:0012310" ; a owl:Class ; rdfs:label "Abnormal monocyte count" ; rdfs:subClassOf obo:HP_0011893, obo:HP_0012144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012311 obo:IAO_0000115 "An increased number of circulating monocytes." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:09:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19636003", "UMLS:C0085702" ; oboInOwl:hasExactSynonym "High blood monocyte number" ; oboInOwl:id "HP:0012311" ; a owl:Class ; rdfs:label "Monocytosis" ; rdfs:subClassOf obo:HP_0012310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012312 obo:IAO_0000115 "An decreased number of circulating monocytes." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:10:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:165539005", "UMLS:C0427544" ; oboInOwl:hasExactSynonym "Low blood monocyte number" ; oboInOwl:id "HP:0012312" ; a owl:Class ; rdfs:label "Monocytopenia" ; rdfs:subClassOf obo:HP_0012310 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012313 obo:IAO_0000115 "Bony swelling of the distal interphalangeal joint (DIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:19:59Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:371598009", "UMLS:C0018862" ; oboInOwl:id "HP:0012313" ; a owl:Class ; rdfs:comment "Heberden's nodes are nodular deformities at the distal interphalangeal joint of the fingers (usually the middle and index) and are commonly seen in the elderly. The deformity is created by osteophyte formation and synovial thickening at the margin ofan osteoarthritic joint. Significant functional problems are rarely encountered though patients may suffer with stiffness and pain. Surgical intervention is seldom indicated unless there is severe pain or instability. In such cases, a joint fusion may be appropriate." ; rdfs:label "Heberden's node" ; rdfs:subClassOf obo:HP_0006247 . obo:HP_0012314 obo:IAO_0000115 "Bony swelling of the proximal interphalangeal joint (PIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:27:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:20243008", "UMLS:C0263780" ; oboInOwl:id "HP:0012314" ; a owl:Class ; rdfs:comment "Heberden's nodes are generally a sign of osteoarthritis." ; rdfs:label "Bouchard's node" ; rdfs:subClassOf obo:HP_0006247 . obo:HP_0012315 obo:IAO_0000115 "A neoplasm containing histiocytes." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:30:05Z" ; oboInOwl:hasDbXref "MSH:D051642", "SNOMEDCT_US:128741006", "SNOMEDCT_US:302843004", "UMLS:C1509147" ; oboInOwl:id "HP:0012315" ; a owl:Class ; rdfs:label "Histiocytoma" ; rdfs:subClassOf obo:HP_0012316 . obo:HP_0012316 obo:IAO_0000115 "Any neoplasm composed of fibrous tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:31:38Z" ; oboInOwl:hasDbXref "MSH:D018218", "UMLS:C0206643" ; oboInOwl:id "HP:0012316" ; a owl:Class ; rdfs:label "Fibrous tissue neoplasm" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0012317 obo:IAO_0000115 "Inflammation of the sacroiliac joint, generally accompanied by lower back pain." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T12:58:43Z" ; oboInOwl:hasDbXref "MSH:C563037", "UMLS:C0748473" ; oboInOwl:hasExactSynonym "Sacroiliitis" ; oboInOwl:id "HP:0012317" ; a owl:Class ; rdfs:label "Sacroiliac arthritis" ; rdfs:subClassOf obo:HP_0002758, obo:HP_0100781 . obo:HP_0012318 obo:IAO_0000115 "A distinct type of headache characterized by piercing, throbbing, or electric-shock-like chronic pain in the upper neck, back of the head, and behind the ears, usually on one side." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T01:07:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:71760005", "UMLS:C0007863" ; oboInOwl:id "HP:0012318" ; a owl:Class ; rdfs:comment "Typically, the pain of occipital neuralgia begins at the base of the head and spreads upward within the distribution of the greater and lesser occipital nerves. Characteristically, it is neuropathic, with paroxysmal episodes of shooting electric shock-like symptoms." ; rdfs:label "Occipital neuralgia" ; rdfs:subClassOf obo:HP_0002315, obo:HP_0033345 . obo:HP_0012319 obo:IAO_0000115 "Lack of skin pigmentation (coloring) of the abdomen." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T08:21:54Z" ; oboInOwl:hasDbXref "UMLS:C4022956" ; oboInOwl:id "HP:0012319" ; a owl:Class ; rdfs:label "Absent pigmentation of the abdomen" ; rdfs:subClassOf obo:HP_0200098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001416 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012320 obo:IAO_0000115 "Lack of skin pigmentation (coloring) of the arms and legs." ; dcterms:creator ; oboInOwl:creation_date "2013-08-10T08:22:30Z" ; oboInOwl:hasDbXref "UMLS:C4022955" ; oboInOwl:id "HP:0012320" ; a owl:Class ; rdfs:label "Absent pigmentation of the limbs" ; rdfs:subClassOf obo:HP_0200098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001419 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012321 obo:IAO_0000115 "An increased concentration of 2-hydroxyglutaric acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-08-11T08:46:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237960000", "UMLS:C1833429" ; oboInOwl:id "HP:0012321" ; a owl:Class ; rdfs:label "D-2-hydroxyglutaric aciduria" ; rdfs:subClassOf obo:HP_0032278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_32796 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012322 obo:IAO_0000115 "Inflammation surrounding hair follicles." ; dcterms:creator ; oboInOwl:creation_date "2013-08-11T09:25:58Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:83341004", "UMLS:C0263006" ; oboInOwl:hasExactSynonym "Perifollicular inflammation" ; oboInOwl:id "HP:0012322" ; a owl:Class ; rdfs:label "Perifolliculitis" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0012323 obo:IAO_0000115 "Myoclonus that occurs during the initial phases of sleep." ; dcterms:creator ; oboInOwl:creation_date "2013-08-11T10:21:47Z" ; oboInOwl:hasDbXref "MSH:D009207", "SNOMEDCT_US:34101000119105", "UMLS:C0751352" ; oboInOwl:id "HP:0012323" ; a owl:Class ; rdfs:label "Sleep myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0012324 obo:IAO_0000115 "A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T06:38:18Z" ; oboInOwl:hasDbXref "MSH:D007951", "SNOMEDCT_US:128934006", "SNOMEDCT_US:188732008", "SNOMEDCT_US:37810007", "UMLS:C0023470" ; oboInOwl:hasExactSynonym "Myeloid leukaemia" ; oboInOwl:id "HP:0012324" ; a owl:Class ; rdfs:label "Myeloid leukemia" ; rdfs:subClassOf obo:HP_0001909 . obo:HP_0012325 obo:IAO_0000115 "A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T06:45:11Z" ; oboInOwl:hasDbXref "MSH:D015477", "SNOMEDCT_US:127225006", "SNOMEDCT_US:128831004", "UMLS:C0023480" ; oboInOwl:hasExactSynonym "Chronic myelomonocytic leukaemia" ; oboInOwl:id "HP:0012325" ; a owl:Class ; rdfs:label "Chronic myelomonocytic leukemia" ; rdfs:subClassOf obo:HP_0012324 . obo:HP_0012326 obo:IAO_0000115 "An anomaly of the celiac artery." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T08:47:21Z" ; oboInOwl:hasDbXref "UMLS:C4022954" ; oboInOwl:hasExactSynonym "Abnormal coeliac artery morphology", "Abnormality of the celiac artery", "Abnormality of the coeliac artery" ; oboInOwl:id "HP:0012326" ; a owl:Class ; rdfs:comment "The celiac artery (celiac trunk or truncus coeliacus) is the first major branch of the abdominal aorta." ; rdfs:label "Abnormal celiac artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012327 obo:IAO_0000115 "Compression of the celiac artery." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T08:49:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:9250002", "UMLS:C0152098", "UMLS:C4020693" ; oboInOwl:hasExactSynonym "Coeliac artery compression" ; oboInOwl:hasRelatedSynonym "Celiac axis syndrome", "Coeliac axis syndrome", "Dunbar syndrome", "Median arcuate ligament syndrome" ; oboInOwl:id "HP:0012327" ; a owl:Class ; rdfs:comment "This feature may be characterized by abdominal pain related to compression of the celiac artery by fibers of the median arcuate ligament." ; rdfs:label "Celiac artery compression" ; rdfs:subClassOf obo:HP_0012326 . obo:HP_0012328 obo:IAO_0000115 "An odontogenic tumor of the cementum of tooth." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T08:55:10Z" ; oboInOwl:hasDbXref "MSH:D002485", "SNOMEDCT_US:23255001", "SNOMEDCT_US:37258009", "UMLS:C0007659" ; oboInOwl:id "HP:0012328" ; a owl:Class ; rdfs:label "Cementoma" ; rdfs:subClassOf obo:HP_0100612 . obo:HP_0012329 obo:IAO_0000115 "A vascular tumor of the skin and subcutaneous tissues and characterized by slow angiomatous proliferation." ; dcterms:creator ; oboInOwl:creation_date "2013-08-12T08:57:58Z" ; oboInOwl:hasDbXref "MSH:C536924", "SNOMEDCT_US:254786000", "SNOMEDCT_US:705155008", "UMLS:C0346073" ; oboInOwl:hasExactSynonym "Angioblastoma", "Angioblastoma of Nakagawa", "Hypertrophic hemangioma", "Progressive capillary hemangioma", "Tufted hemangioma" ; oboInOwl:id "HP:0012329" ; a owl:Class ; rdfs:label "Tufted angioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0012330 obo:IAO_0000115 "An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T07:37:08Z" ; oboInOwl:hasDbXref "MSH:D011704", "SNOMEDCT_US:45816000", "UMLS:C0034186" ; oboInOwl:id "HP:0012330" ; a owl:Class ; rdfs:comment "Pyelonephritis may be unilateral or bilateral and is often characterized by abdominal pain, fever, nausea, and vomiting." ; rdfs:label "Pyelonephritis" ; rdfs:subClassOf obo:HP_0000123 . obo:HP_0012331 obo:IAO_0000115 "A structural abnormality of the autonomic nervous system." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T07:52:31Z" ; oboInOwl:hasDbXref "UMLS:C4022953" ; oboInOwl:id "HP:0012331" ; a owl:Class ; rdfs:label "Abnormal autonomic nervous system morphology" ; rdfs:subClassOf obo:HP_0002270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002410 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012332 obo:IAO_0000115 "A functional abnormality of the autonomic nervous system." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T07:53:55Z" ; oboInOwl:hasAlternativeId "HP:0002271", "HP:0002387", "HP:0002459", "HP:0007310" ; oboInOwl:hasDbXref "UMLS:C4022952" ; oboInOwl:hasExactSynonym "Autonomic dysfunction", "Autonomic dysregulation", "Dysautonomia" ; oboInOwl:id "HP:0012332" ; a owl:Class ; rdfs:label "Abnormal autonomic nervous system physiology" ; rdfs:subClassOf obo:HP_0002270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002410 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012333 obo:IAO_0000115 "An abnormal regulation of the sweat glands by the sympathetic nervous system associated with abnormal perspiration." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T08:04:38Z" ; oboInOwl:hasDbXref "UMLS:C4021092" ; oboInOwl:hasExactSynonym "Sudomotor sympathetic dysfunction" ; oboInOwl:id "HP:0012333" ; a owl:Class ; rdfs:comment "Normally, the cholinergic innervation via the sympathetic nervous system activates muscarinic acetylcholine receptors in sweat glands, thereby leading to perspiration. This terms refers to an abnormally increased or decreased activity of this system." ; rdfs:label "Abnormal sudomotor regulation" ; rdfs:subClassOf obo:HP_0012332 . obo:HP_0012334 obo:IAO_0000115 "Impairment of bile flow due to obstruction in large bile ducts outside the liver." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T08:13:48Z" ; oboInOwl:hasDbXref "MSH:D001651", "SNOMEDCT_US:20719006", "SNOMEDCT_US:8262006", "UMLS:C0005398" ; oboInOwl:id "HP:0012334" ; a owl:Class ; rdfs:label "Extrahepatic cholestasis" ; rdfs:subClassOf obo:HP_0001396 . obo:HP_0012335 obo:IAO_0000115 "An abnormality of the metabolism of folic acid, which is also known as vitamin B9." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T08:38:06Z" ; oboInOwl:hasDbXref "UMLS:C4022951" ; oboInOwl:id "HP:0012335" ; a owl:Class ; rdfs:label "Abnormality of folate metabolism" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0012336 obo:IAO_0100001 "HP:0012446" ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T08:39:17Z" ; oboInOwl:id "HP:0012336" ; a owl:Class ; rdfs:label "obsolete Reduced cerebrospinal fluid 5-methyltetrahydrofolate concentration" ; owl:deprecated true . obo:HP_0012337 obo:IAO_0000115 "An anomaly in the processes involved in the maintenance of an internal equilibrium." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:23:23Z" ; oboInOwl:hasDbXref "MP:0001764", "UMLS:C4022950" ; oboInOwl:id "HP:0012337" ; a owl:Class ; rdfs:label "Abnormal homeostasis" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0012338 obo:IAO_0000115 "Any anomaly in the utilization of energy (calories)." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:24:54Z" ; oboInOwl:hasDbXref "UMLS:C4022949" ; oboInOwl:hasExactSynonym "Abnormal energy expenditure" ; oboInOwl:id "HP:0012338" ; a owl:Class ; rdfs:label "Abnormal energy expenditure" ; rdfs:subClassOf obo:HP_0012337 . obo:HP_0012339 obo:IAO_0000115 "An increase in the number of calories used per unit time." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:25:29Z" ; oboInOwl:hasDbXref "UMLS:C4022948" ; oboInOwl:id "HP:0012339" ; a owl:Class ; rdfs:label "Increased resting energy expenditure" ; rdfs:subClassOf obo:HP_0012338 . obo:HP_0012340 obo:IAO_0000115 "A reduction in the number of calories used per unit time." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:27:05Z" ; oboInOwl:hasDbXref "UMLS:C4022947" ; oboInOwl:id "HP:0012340" ; a owl:Class ; rdfs:label "Decreased resting energy expenditure" ; rdfs:subClassOf obo:HP_0012338 . obo:HP_0012341 obo:IAO_0000115 "A pituitary prolactin cell adenoma of less than 10 mm diameter." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:49:32Z" ; oboInOwl:hasDbXref "MSH:D015175", "SNOMEDCT_US:253010003", "UMLS:C0344452" ; oboInOwl:id "HP:0012341" ; a owl:Class ; rdfs:label "Microprolactinoma" ; rdfs:subClassOf obo:HP_0006767 . obo:HP_0012342 obo:IAO_0000115 "A pituitary prolactin cell adenoma of more than 10 mm diameter." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:50:29Z" ; oboInOwl:hasDbXref "MSH:D015175", "SNOMEDCT_US:253011004", "UMLS:C0344453" ; oboInOwl:id "HP:0012342" ; a owl:Class ; rdfs:label "Macroprolactinoma" ; rdfs:subClassOf obo:HP_0006767 . obo:HP_0012343 obo:IAO_0000115 "Abnormally reduced concentration of ferritin, a ubiquitous intracellular protein that stores iron, in the blood." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:51:46Z" ; oboInOwl:hasDbXref "UMLS:C0241012" ; oboInOwl:hasExactSynonym "Decreased plasma ferritin", "Decreased serum ferritin", "Low ferritin level", "Reduced serum ferritin" ; oboInOwl:id "HP:0012343" ; a owl:Class ; rdfs:comment "Ferritin levels measured in serum usually have a direct correlation with the total amount of iron stored in the body, but ferritin levels may also be increased with anemia of chronic disease or in the course of an acute phase reaction." ; rdfs:label "Decreased circulating ferritin concentration" ; rdfs:subClassOf obo:HP_0040133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070288 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012344 obo:IAO_0000115 "Isolated patches of hardened skin (scleroderma)." ; dcterms:creator ; oboInOwl:creation_date "2013-09-13T09:55:47Z" ; oboInOwl:hasDbXref "MSH:D012594", "SNOMEDCT_US:201049004", "UMLS:C1527383" ; oboInOwl:id "HP:0012344" ; a owl:Class ; rdfs:label "Morphea" ; rdfs:subClassOf obo:HP_0001072 . obo:HP_0012345 obo:IAO_0000115 "An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T09:06:16Z" ; oboInOwl:hasDbXref "UMLS:C4022946" ; oboInOwl:id "HP:0012345" ; a owl:Class ; rdfs:label "Abnormal glycosylation" ; rdfs:subClassOf obo:HP_0032245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012346 obo:IAO_0000115 "An anomaly of a protein glycosylation process, i.e., of a protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T09:09:40Z" ; oboInOwl:hasDbXref "UMLS:C4022945" ; oboInOwl:id "HP:0012346" ; a owl:Class ; rdfs:label "Abnormal protein glycosylation" ; rdfs:subClassOf obo:HP_0012345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006486 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012347 obo:IAO_0000115 "An anomaly of protein N-linked glycosylation, i.e., an abnormality of the protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a nitrogen atom in an amino acid residue in a protein." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T09:29:59Z" ; oboInOwl:hasDbXref "UMLS:C4022944" ; oboInOwl:id "HP:0012347" ; a owl:Class ; rdfs:comment "Essentially, all proteins (except albumin) that travel through the ER-Golgi network undergo N-linked glycosylation. Glycans promote protein folding, stability, trafficking, localisation, and oligomerisation. They play vital parts in cell-cell interactions and intracellular signalling." ; rdfs:label "Abnormal protein N-linked glycosylation" ; rdfs:subClassOf obo:HP_0012346 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006487 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012348 obo:IAO_0000115 "A reduction in the amount of galactose residues of N-glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:02:47Z" ; oboInOwl:hasDbXref "UMLS:C4022943" ; oboInOwl:id "HP:0012348" ; a owl:Class ; rdfs:comment "The majority of complex and hybrid N-glycans have elongated branches that are made by the addition of a beta-linked galactose residue to the initiating N-acetylglucosamine to produce the ubiquitous building block Gal-beta-linked1-4GlcNAc, referred to as a type-2 N-acetyllactosamine (LacNAc) sequence." ; rdfs:label "Decreased galactosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0012349 obo:IAO_0000115 "An anomaly of the addition of sialic acids to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:08:34Z" ; oboInOwl:hasDbXref "UMLS:C4022942" ; oboInOwl:id "HP:0012349" ; a owl:Class ; rdfs:comment "The most common sialic acids is N-acetylneuraminic acid (Neu5Ac)." ; rdfs:label "Abnormal sialylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0012350 obo:IAO_0000115 "Decreased addition of sialic acids to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:14:42Z" ; oboInOwl:hasDbXref "UMLS:C4022941" ; oboInOwl:id "HP:0012350" ; a owl:Class ; rdfs:label "Decreased sialylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012349 . obo:HP_0012351 obo:IAO_0000115 "Increased addition of sialic acids to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:15:28Z" ; oboInOwl:hasDbXref "UMLS:C4022940" ; oboInOwl:id "HP:0012351" ; a owl:Class ; rdfs:label "Increased sialylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012349 . obo:HP_0012352 obo:IAO_0000115 "An anomaly of the addition of fucose sugar units to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:17:55Z" ; oboInOwl:hasDbXref "UMLS:C4022939" ; oboInOwl:id "HP:0012352" ; a owl:Class ; rdfs:label "Abnormal fucosylation of protein N-linked glycosylation" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0012353 obo:IAO_0000115 "Decreased addition of fucose sugar units to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:20:00Z" ; oboInOwl:hasDbXref "UMLS:C4022938" ; oboInOwl:id "HP:0012353" ; a owl:Class ; rdfs:label "Decreased fucosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012352 . obo:HP_0012354 obo:IAO_0000115 "Increased addition of fucose sugar units to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:21:15Z" ; oboInOwl:hasDbXref "UMLS:C4022937" ; oboInOwl:id "HP:0012354" ; a owl:Class ; rdfs:label "Increased fucosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012352 . obo:HP_0012355 obo:IAO_0000115 "An anomaly of the addition of mannose to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:23:53Z" ; oboInOwl:hasDbXref "UMLS:C4022936" ; oboInOwl:id "HP:0012355" ; a owl:Class ; rdfs:label "Abnormal mannosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0012356 obo:IAO_0000115 "Reduced addition of mannose to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:24:56Z" ; oboInOwl:hasDbXref "UMLS:C4022935" ; oboInOwl:id "HP:0012356" ; a owl:Class ; rdfs:label "Decreased mannosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012355 . obo:HP_0012357 obo:IAO_0000115 "Increased addition of mannose to N-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:25:28Z" ; oboInOwl:hasDbXref "UMLS:C4022934" ; oboInOwl:id "HP:0012357" ; a owl:Class ; rdfs:label "Increased mannosylation of N-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012355 . obo:HP_0012358 obo:IAO_0000115 "An anomaly of protein O-linked glycosylation, i.e., of the process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of a serine or threonine residue." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:26:49Z" ; oboInOwl:hasDbXref "UMLS:C4022933" ; oboInOwl:id "HP:0012358" ; a owl:Class ; rdfs:label "Abnormal protein O-linked glycosylation" ; rdfs:subClassOf obo:HP_0012346 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006493 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012359 obo:IAO_0000115 "An anomaly of the addition of fucose sugar units to O-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:31:07Z" ; oboInOwl:hasDbXref "UMLS:C4022932" ; oboInOwl:id "HP:0012359" ; a owl:Class ; rdfs:label "Abnormal fucosylation of O-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0036066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012360 obo:IAO_0000115 "A reduction of the addition of fucose sugar units to O-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:33:00Z" ; oboInOwl:hasDbXref "UMLS:C4022931" ; oboInOwl:id "HP:0012360" ; a owl:Class ; rdfs:label "Decreased fucosylation of O-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012359 . obo:HP_0012361 obo:IAO_0000115 "Increased addition of fucose sugar units to O-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:34:38Z" ; oboInOwl:hasDbXref "UMLS:C4022930" ; oboInOwl:id "HP:0012361" ; a owl:Class ; rdfs:label "Increased fucosylation of O-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012359 . obo:HP_0012362 obo:IAO_0000115 "An anomaly of the addition of sialic acids to O-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:36:12Z" ; oboInOwl:hasDbXref "UMLS:C4022929" ; oboInOwl:id "HP:0012362" ; a owl:Class ; rdfs:label "Abnormal sialylation of O-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012358 . obo:HP_0012363 obo:IAO_0000115 "An reduced addition of sialic acids to O-linked glycans." ; dcterms:creator ; oboInOwl:creation_date "2013-09-15T10:36:43Z" ; oboInOwl:hasDbXref "UMLS:C4022928" ; oboInOwl:id "HP:0012363" ; a owl:Class ; rdfs:label "Decreased sialylation of O-linked protein glycosylation" ; rdfs:subClassOf obo:HP_0012362 . obo:HP_0012364 obo:IAO_0000115 "A decreased concentration of potassium(1+) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-10-03T10:21:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:54781007", "UMLS:C0268024" ; oboInOwl:hasExactSynonym "Decreased urinary K", "Hypokaliuria", "Hypokaluria", "Low urine potassium levels" ; oboInOwl:id "HP:0012364" ; a owl:Class ; rdfs:label "Decreased urinary potassium" ; rdfs:subClassOf obo:HP_0012598 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012365 obo:IAO_0000115 "An abnormally decreased phosphate concentration in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-10-03T10:25:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:91632005", "UMLS:C0268077" ; oboInOwl:hasExactSynonym "Low urine phosphate levels" ; oboInOwl:id "HP:0012365" ; a owl:Class ; rdfs:label "Hypophosphaturia" ; rdfs:subClassOf obo:HP_0012599 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012366 obo:IAO_0000115 "Projection of the tip of the dens more than 5 mm above a line joining the hard palate to the posterior lip of the foramen magnum (Chamberlain's line) or the tip of the dens is greater than 7 mm above McGregor's line (the back of the hard palate to the lowest point of the occipital squama)." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T12:18:53Z" ; oboInOwl:hasDbXref "UMLS:C3887851" ; oboInOwl:id "HP:0012366" ; a owl:Class ; rdfs:label "Basilar invagination" ; rdfs:subClassOf obo:HP_0000932 . obo:HP_0012367 obo:IAO_0000115 "Bony defects situated along the cranial suture lines or at the junction of the bone plates of the skull." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T12:27:03Z" ; oboInOwl:hasDbXref "UMLS:C4022927" ; oboInOwl:id "HP:0012367" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Extra fontanelles include glabellar, metopic, sagittal (parietal) and cerebellar fontanelles." ; rdfs:label "Extra fontanelles" ; rdfs:subClassOf obo:HP_0011328 . obo:HP_0012368 obo:IAO_0000115 "Absence of concavity or convexity of the face when viewed in profile." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T01:49:13Z" ; oboInOwl:hasDbXref "UMLS:C1853241" ; oboInOwl:hasExactSynonym "Flat face", "Flat facial profile", "Flat facial shape", "Flat facies" ; oboInOwl:id "HP:0012368" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "A useful guide is to imagine that a line connecting the glabella to the anterior most part of the mandible touches the top of the philtrum where it meets the base of the columella. The glabella is the most prominent point on the frontal bone above the root of the nose. If the superior philtrum is anterior to this line the face is convex, if the superior philtrum is posterior to this line the face is concave." ; rdfs:label "Flat face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012369 obo:IAO_0100001 "HP:0010668" ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T02:37:51Z" ; oboInOwl:id "HP:0012369" ; a owl:Class ; rdfs:label "obsolete Abnormal malar bone morphology" ; owl:deprecated true . obo:HP_0012370 obo:IAO_0000115 "Large or prominent malar surface of the zygomatic bone of the skull, which is convex and forms the prominence of the 'cheek bones'." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T02:50:15Z" ; oboInOwl:hasBroadSynonym "Cheekbone excess", "Zygomatic bone excess" ; oboInOwl:hasDbXref "SNOMEDCT_US:427888001", "UMLS:C0375511", "UMLS:C1997760", "UMLS:C4082245" ; oboInOwl:hasExactSynonym "Cheekbone prominence", "Malar hypertrophy", "Prominence of cheekbone", "Pronounced cheekbone" ; oboInOwl:hasNarrowSynonym "Hyperplasia of cheekbone", "Hyperplasia of zygomatic bone", "Zygomatic hypertrophy" ; oboInOwl:id "HP:0012370" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Prominence of the zygomatic bone" ; rdfs:subClassOf obo:HP_0010668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001683 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012371 obo:IAO_0000115 "Abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face" ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T02:55:54Z" ; oboInOwl:hasAlternativeId "HP:0010279" ; oboInOwl:hasBroadSynonym "Big midface", "Large midface" ; oboInOwl:hasDbXref "UMLS:C0240309" ; oboInOwl:hasExactSynonym "Midface hyperplasia", "Midfacial excess", "Midfacial prominence" ; oboInOwl:hasRelatedSynonym "Hypertrophy of midface", "Overgrowth of the midface" ; oboInOwl:id "HP:0012371" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This term represents increased size of the maxilla (upper jaw) in length (increased midface height) or anterior-posterior projection (midface prominence). In the presence of normal mandible size, maxillary prominence may give the appearance of retrognathia." ; rdfs:label "Hyperplasia of midface" ; rdfs:subClassOf obo:HP_0000309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004089 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012372 obo:IAO_0000115 "A structural anomaly of the globe of the eye, or bulbus oculi." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T03:44:43Z" ; oboInOwl:hasAlternativeId "HP:0000489", "HP:0012374" ; oboInOwl:hasDbXref "Fyler:4863", "UMLS:C4022925" ; oboInOwl:hasExactSynonym "Abnormal eye structure", "Abnormality of the globe", "Abnormally shaped eye" ; oboInOwl:id "HP:0012372" ; a owl:Class ; rdfs:comment "previously: Abnormal globe morphology" ; rdfs:label "Abnormal eye morphology" ; rdfs:subClassOf obo:HP_0000478 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012373 obo:IAO_0000115 "A functional anomaly of the eye." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T03:45:37Z" ; oboInOwl:hasDbXref "UMLS:C4022924" ; oboInOwl:hasExactSynonym "Abnormal eye physiology" ; oboInOwl:id "HP:0012373" ; a owl:Class ; rdfs:label "Abnormal eye physiology" ; rdfs:subClassOf obo:HP_0000478 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012374 obo:IAO_0100001 "HP:0012372" ; oboInOwl:id "HP:0012374" ; a owl:Class ; rdfs:label "obsolete Abnormal globe morphology" ; owl:deprecated true . obo:HP_0012375 obo:IAO_0000115 "Edema (swelling) of the bulbar conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T05:45:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:8148005", "UMLS:C0271298" ; oboInOwl:id "HP:0012375" ; a owl:Class ; rdfs:label "Chemosis" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0012376 obo:IAO_0000115 "Abnormal smallness of the lens." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T06:11:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:35272001", "UMLS:C0266541" ; oboInOwl:hasExactSynonym "Small lens" ; oboInOwl:id "HP:0012376" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Microphakia" ; rdfs:subClassOf obo:HP_0008063 . obo:HP_0012377 obo:IAO_0000115 "Partial or complete loss of vision in one half of the visual field of one or both eyes." ; dcterms:creator ; oboInOwl:creation_date "2013-10-13T07:55:21Z" ; oboInOwl:hasDbXref "MSH:D006423", "SNOMEDCT_US:77674003", "UMLS:C0018979" ; oboInOwl:hasExactSynonym "Hemianopsia" ; oboInOwl:id "HP:0012377" ; a owl:Class ; rdfs:label "Hemianopia" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0012378 obo:IAO_0000115 "A subjective feeling of tiredness characterized by a lack of energy and motivation." ; dcterms:creator ; oboInOwl:creation_date "2013-10-15T08:52:04Z" ; oboInOwl:hasDbXref "MSH:D005221", "SNOMEDCT_US:248274002", "SNOMEDCT_US:84229001", "UMLS:C0015672" ; oboInOwl:hasExactSynonym "Fatigue", "Tired", "Tiredness" ; oboInOwl:id "HP:0012378" ; a owl:Class ; rdfs:comment "Fatigue is distinct from muscle weakness." ; rdfs:label "Fatigue" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0012379 obo:IAO_0000115 "Concentration or activity of an enzyme is above or below the limits of normal in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2013-10-15T08:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022922" ; oboInOwl:id "HP:0012379" ; a owl:Class ; rdfs:label "Abnormal circulating enzyme concentration or activity" ; rdfs:subClassOf obo:HP_0034684 . obo:HP_0012380 obo:IAO_0000115 "Reduced carnitine O-palmitoyltransferase level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." ; dcterms:creator ; oboInOwl:creation_date "2013-10-15T09:00:17Z" ; oboInOwl:hasDbXref "UMLS:C4022921" ; oboInOwl:id "HP:0012380" ; a owl:Class ; rdfs:label "Reduced carnitine O-palmitoyltransferase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004095 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012381 obo:IAO_0000115 "A delay in the development of skills required to feed oneself in the toddler period (between one and three years of age)." ; dcterms:creator ; oboInOwl:creation_date "2013-10-16T11:46:54Z" ; oboInOwl:hasDbXref "UMLS:C4022920" ; oboInOwl:id "HP:0012381" ; a owl:Class ; rdfs:label "Delayed self-feeding during toddler years" ; rdfs:subClassOf obo:HP_0011968 . obo:HP_0012382 obo:IAO_0000115 "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the left side of the heart to the right." ; dcterms:creator ; oboInOwl:creation_date "2013-10-16T11:54:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:66130006", "UMLS:C0428870" ; oboInOwl:id "HP:0012382" ; a owl:Class ; rdfs:label "Left-to-right shunt" ; rdfs:subClassOf obo:HP_0001693 . obo:HP_0012383 obo:IAO_0000115 "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from both right side of the heart to the left and vice versa." ; dcterms:creator ; oboInOwl:creation_date "2013-10-16T11:54:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:13352000", "UMLS:C0428872" ; oboInOwl:id "HP:0012383" ; a owl:Class ; rdfs:label "Bidirectional shunt" ; rdfs:subClassOf obo:HP_0001693 . obo:HP_0012384 obo:IAO_0000115 "Inflammation of the nasal mucosa with nasal congestion." ; dcterms:creator ; oboInOwl:creation_date "2013-10-19T05:37:08Z" ; oboInOwl:hasDbXref "MSH:D012220", "SNOMEDCT_US:70076002", "UMLS:C0035455", "UMLS:C2718128" ; oboInOwl:hasExactSynonym "Nasal inflammation" ; oboInOwl:id "HP:0012384" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Rhinitis" ; rdfs:subClassOf obo:HP_0000366 . obo:HP_0012385 obo:IAO_0000115 "The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers or toes cannot be extended to 180 degrees by either active or passive extension." ; dcterms:creator ; oboInOwl:creation_date "2013-10-20T08:08:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:29271008", "UMLS:C0685409" ; oboInOwl:hasExactSynonym "Permanent flexion of the finger or toe" ; oboInOwl:id "HP:0012385" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Camptodactyly" ; rdfs:subClassOf obo:HP_0030044 . obo:HP_0012386 obo:IAO_0000115 "Aplasia of the hallux, that is, a development defect such that the big toe does not develop." ; dcterms:creator ; oboInOwl:creation_date "2013-10-20T12:03:14Z" ; oboInOwl:hasDbXref "UMLS:C1841686" ; oboInOwl:hasExactSynonym "Absent big toe", "Agenesis of the halluces", "Aplasia of the hallux", "Missing big toe" ; oboInOwl:id "HP:0012386" ; a owl:Class ; rdfs:label "Absent hallux" ; rdfs:subClassOf obo:HP_0008362 . obo:HP_0012387 obo:IAO_0000115 "Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:24:16Z" ; oboInOwl:hasDbXref "MSH:D001991", "SNOMEDCT_US:32398004", "UMLS:C0006277" ; oboInOwl:id "HP:0012387" ; a owl:Class ; rdfs:label "Bronchitis" ; rdfs:subClassOf obo:HP_0011947 . obo:HP_0012388 obo:IAO_0000115 "Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:27:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:10509002", "SNOMEDCT_US:35301006", "UMLS:C0149514" ; oboInOwl:id "HP:0012388" ; a owl:Class ; rdfs:label "Acute bronchitis" ; rdfs:subClassOf obo:HP_0012387 . obo:HP_0012389 obo:IAO_0000115 "Muscular hypotonia of one or more limbs." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:31:51Z" ; oboInOwl:hasDbXref "UMLS:C4022919" ; oboInOwl:id "HP:0012389" ; a owl:Class ; rdfs:label "Appendicular hypotonia" ; rdfs:subClassOf obo:HP_0001252 . obo:HP_0012390 obo:IAO_0000115 "A small tear in the thin, moist tissue (mucosa) that lines the anus. It appears as a crack or slit in the mucous membrane of the anus." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:36:49Z" ; oboInOwl:hasDbXref "MSH:D005401", "SNOMEDCT_US:20928004", "SNOMEDCT_US:30037006", "UMLS:C0016167" ; oboInOwl:hasRelatedSynonym "Anal erosion" ; oboInOwl:id "HP:0012390" ; a owl:Class ; rdfs:label "Anal fissure" ; rdfs:subClassOf obo:HP_0034915 . obo:HP_0012391 obo:IAO_0000115 "Reduced intensity of muscle tendon reflexes in the upper limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:42:49Z" ; oboInOwl:hasDbXref "UMLS:C1836835" ; oboInOwl:id "HP:0012391" ; a owl:Class ; rdfs:label "Hyporeflexia of upper limbs" ; rdfs:subClassOf obo:HP_0001265, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012392 obo:IAO_0000115 "Reduced intensity of muscle tendon reflexes in jaw." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:43:29Z" ; oboInOwl:hasDbXref "UMLS:C4022918" ; oboInOwl:hasExactSynonym "Mandibular hyporeflexia" ; oboInOwl:id "HP:0012392" ; a owl:Class ; rdfs:comment "The jaw jerk is elicited by the examiner placing the tip of the index finger on a relaxed jaw, one that is about one-third open. One then taps briskly on the index finger with the other hand and notes the speed as the mandible is flexed." ; rdfs:label "Jaw hyporeflexia" ; rdfs:subClassOf obo:HP_0001265, obo:HP_0045037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0011648 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012393 obo:IAO_0000115 "An allergy is an immune response or reaction to substances that are usually not harmful." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:47:22Z" ; oboInOwl:hasDbXref "MSH:D006967", "SNOMEDCT_US:419076005", "UMLS:C1527304" ; oboInOwl:hasExactSynonym "Allergy" ; oboInOwl:id "HP:0012393" ; a owl:Class ; rdfs:label "Allergy" ; rdfs:subClassOf obo:HP_0100326 . obo:HP_0012394 obo:IAO_0000115 "Allergy to iodine contrast media used in radiological studies." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:49:32Z" ; oboInOwl:hasDbXref "UMLS:C4022917" ; oboInOwl:id "HP:0012394" ; a owl:Class ; rdfs:label "Iodine contrast allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0012395 obo:IAO_0000115 "An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:51:48Z" ; oboInOwl:hasDbXref "MSH:D006255", "SNOMEDCT_US:21719001", "SNOMEDCT_US:300910009", "SNOMEDCT_US:367498001", "SNOMEDCT_US:444316004", "UMLS:C0018621" ; oboInOwl:hasExactSynonym "Seasonal allergy" ; oboInOwl:id "HP:0012395" ; a owl:Class ; rdfs:label "Seasonal allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0012396 obo:IAO_0000115 "A motility disorder characterized by biliary colic in the absence of gallstones with a reduced gallbladder ejection fraction." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T07:56:55Z" ; oboInOwl:hasDbXref "MSH:D001657", "SNOMEDCT_US:197432008", "UMLS:C0005416" ; oboInOwl:id "HP:0012396" ; a owl:Class ; rdfs:label "Biliary dyskinesia" ; rdfs:subClassOf obo:HP_0012439 . obo:HP_0012397 obo:IAO_0000115 "The presence of atheromas or atherosclerotic plaques in the aorta." ; dcterms:creator ; oboInOwl:creation_date "2013-11-07T08:04:30Z" ; oboInOwl:hasBroadSynonym "Aortic atherosclerosis", "Plaque build-up in aorta artery" ; oboInOwl:hasDbXref "SNOMEDCT_US:81817003", "UMLS:C0155733" ; oboInOwl:hasExactSynonym "Atherosclerosis of the aorta", "Atherosclerotic changes of aorta" ; oboInOwl:id "HP:0012397" ; a owl:Class ; rdfs:label "Aortic atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0001679, obo:HP_0002621 . obo:HP_0012398 obo:IAO_0000115 "An abnormal accumulation of interstitial fluid in the soft tissues of the limbs." ; dcterms:creator ; oboInOwl:creation_date "2013-11-08T08:09:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:271809000", "SNOMEDCT_US:82014009", "UMLS:C0085649" ; oboInOwl:hasExactSynonym "Peripheral oedema" ; oboInOwl:id "HP:0012398" ; a owl:Class ; rdfs:label "Peripheral edema" ; rdfs:subClassOf obo:HP_0000969 . obo:HP_0012399 obo:IAO_0000115 "A type of ulcer that is caused when an area of skin is subject to pressure over a prolonged period of time, ranging in range in severity from patches of discolored skin to open wounds that expose the underlying bone or muscle. The most common sites are the sacrum, coccyx, heels and the hips." ; dcterms:creator ; oboInOwl:creation_date "2013-11-08T08:49:52Z" ; oboInOwl:hasDbXref "MSH:D003668", "SNOMEDCT_US:399912005", "SNOMEDCT_US:420226006", "UMLS:C0011127" ; oboInOwl:hasExactSynonym "Bedsore", "Decubitus Ulcer", "Pressure Sore", "Pressure ulcer" ; oboInOwl:id "HP:0012399" ; a owl:Class ; rdfs:comment "Pressure ulcers tend to affect persons with reduced mobility who are bedridden or wheelchair-bound." ; rdfs:label "Pressure ulcer" ; rdfs:subClassOf obo:HP_0200042 . obo:HP_0012400 obo:IAO_0000115 "An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:35:35Z" ; oboInOwl:hasDbXref "UMLS:C4022916" ; oboInOwl:hasExactSynonym "Abnormal aldolase level" ; oboInOwl:id "HP:0012400" ; a owl:Class ; rdfs:comment "The reaction catalyzed by aldolase is a component of the glycolysis pathway." ; rdfs:label "Abnormal circulating aldolase concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0012401 obo:IAO_0000115 "A deviation from normal of the concentration of 2-oxoglutaric acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:45:40Z" ; oboInOwl:hasDbXref "UMLS:C4020902" ; oboInOwl:hasExactSynonym "Abnormal urinary 2-oxoglutarate level", "Abnormality of urine alpha ketoglutarate concentration" ; oboInOwl:id "HP:0012401" ; a owl:Class ; rdfs:comment "Note that alpha-ketoglutaric acid is also known as 2-ketoglutaric acid, alpha-ketoglutaric acid, 2-xxoglutaric acid, and oxoglutaric acid." ; rdfs:label "Abnormal urine alpha-ketoglutarate concentration" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012402 obo:IAO_0000115 "A greater than normal concentration of 2-oxoglutaric acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:48:37Z" ; oboInOwl:hasDbXref "UMLS:C4022915" ; oboInOwl:hasExactSynonym "Elevated urinary 2-oxoglutarate", "Increased urine alpha-ketoglutarate concentration" ; oboInOwl:id "HP:0012402" ; a owl:Class ; rdfs:comment "Note that alpha-ketoglutaric acid is also known as 2-ketoglutaric acid, alpha-ketoglutaric acid, 2-xxoglutaric acid, and oxoglutaric acid." ; rdfs:label "Increased urine alpha-ketoglutarate concentration" ; rdfs:subClassOf obo:HP_0012401 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012403 obo:IAO_0000115 "A lower than normal concentration of 2-oxoglutaric acid in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:49:45Z" ; oboInOwl:hasDbXref "UMLS:C4022914" ; oboInOwl:hasExactSynonym "Decreased urinary 2-oxoglutarate" ; oboInOwl:id "HP:0012403" ; a owl:Class ; rdfs:comment "Note that alpha-ketoglutaric acid is also known as 2-ketoglutaric acid, alpha-ketoglutaric acid, 2-xxoglutaric acid, and oxoglutaric acid." ; rdfs:label "Decreased urine alpha-ketoglutarate concentration" ; rdfs:subClassOf obo:HP_0012401 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012404 obo:IAO_0000115 "A deviation from normal of the concentration of citrate(3-) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:51:30Z" ; oboInOwl:hasDbXref "UMLS:C4022913" ; oboInOwl:hasExactSynonym "Abnormal urine citrate concentration", "Abnormal urine citric acid concentration" ; oboInOwl:id "HP:0012404" ; a owl:Class ; rdfs:label "Abnormal urine citrate concentration" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16947 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012405 obo:IAO_0000115 "A lower than normal concentration of citrate(3-) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:54:41Z" ; oboInOwl:hasDbXref "UMLS:C2673444" ; oboInOwl:hasExactSynonym "Decreased urine citrate concentration" ; oboInOwl:id "HP:0012405" ; a owl:Class ; rdfs:label "Hypocitraturia" ; rdfs:subClassOf obo:HP_0012404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16947 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012406 obo:IAO_0000115 "A greater than normal concentration of citrate(3-) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T03:56:26Z" ; oboInOwl:hasDbXref "UMLS:C4021090" ; oboInOwl:hasExactSynonym "Increased urine citrate concentration" ; oboInOwl:id "HP:0012406" ; a owl:Class ; rdfs:label "Hypercitraturia" ; rdfs:subClassOf obo:HP_0012404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16947 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012407 obo:IAO_0000115 "A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use." ; dcterms:creator ; oboInOwl:creation_date "2013-11-09T04:15:36Z" ; oboInOwl:hasDbXref "MSH:D020233", "SNOMEDCT_US:22090007", "UMLS:C0231698" ; oboInOwl:hasExactSynonym "Scissor gait", "Scissor walk", "Scissors gait" ; oboInOwl:id "HP:0012407" ; a owl:Class ; rdfs:comment "Scissor gait is a form of gait abnormality primarily associated with spastic cerebral palsy." ; rdfs:label "Scissor gait" ; rdfs:subClassOf obo:HP_0031958 . obo:HP_0012408 obo:IAO_0000115 "The deposition of calcium salts in the parenchyma of the renal medulla (innermost part of the kidney)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T10:45:27Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:236447005", "UMLS:C0403477" ; oboInOwl:id "HP:0012408" ; a owl:Class ; rdfs:label "Medullary nephrocalcinosis" ; rdfs:subClassOf obo:HP_0000121 . obo:HP_0012409 obo:IAO_0000115 "The deposition of calcium salts in the parenchyma of the renal cortex (the outer portion of the kidney between the renal capsule and the renal medulla)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T11:03:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:236446001", "UMLS:C0403476" ; oboInOwl:id "HP:0012409" ; a owl:Class ; rdfs:label "Cortical nephrocalcinosis" ; rdfs:subClassOf obo:HP_0000121 . obo:HP_0012410 obo:IAO_0000115 "A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T11:36:59Z" ; oboInOwl:hasDbXref "MSH:D012010", "SNOMEDCT_US:50715003", "UMLS:C0034902" ; oboInOwl:hasExactSynonym "Red cell aplasia" ; oboInOwl:id "HP:0012410" ; a owl:Class ; rdfs:comment "Pure red cell aplasia results from a maturation arrest occurs in the formation of erythrocytes." ; rdfs:label "Pure red cell aplasia" ; rdfs:subClassOf obo:HP_0012131 . obo:HP_0012411 obo:IAO_0000115 "The onset of growth of pubic hair at an earlier age than normal." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T11:50:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237815000", "UMLS:C0342541" ; oboInOwl:hasExactSynonym "Premature pubic hair growth" ; oboInOwl:id "HP:0012411" ; a owl:Class ; rdfs:label "Premature pubarche" ; rdfs:subClassOf obo:HP_0000826 . obo:HP_0012412 obo:IAO_0000115 "Onset of adrenarche at an earlier age than usual." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T11:58:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:103021001", "UMLS:C0342546" ; oboInOwl:id "HP:0012412" ; a owl:Class ; rdfs:comment "Adrenarche is an early sexual maturation stage that typically occurs at around 6 to 8 years of age, during which the adrenal cortex begins to secrete increased levels of androgens resulting from the development of the zona reticularis in the adrenal cortex. Note that pubarche refers to the development of pubic hair, axillary hair, and adult sweat gland (apocrine) odor. The physical features associated with pubarche reflect the onset of adrenarche, which refers to the pubertal maturation of the adrenal and is associated with increased secretion of an adrenal hormone called dehydroepiandrosterone sulfate (DHEAS)." ; rdfs:label "Premature adrenarche" ; rdfs:subClassOf obo:HP_0100000 . obo:HP_0012413 obo:IAO_0000115 "The presence of a V-shaped indentation (notch) in the primary central incisor." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T12:07:34Z" ; oboInOwl:hasDbXref "MSH:D013590", "SNOMEDCT_US:410500004", "SNOMEDCT_US:86443005", "UMLS:C0020186", "UMLS:C1444627", "UMLS:C4022912" ; oboInOwl:hasExactSynonym "Notched front baby tooth", "Notched front deciduous tooth", "Notched front primary tooth", "Syphilitic primary incisor" ; oboInOwl:id "HP:0012413" ; a owl:Class ; rdfs:label "Notched primary central incisor" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0012414 obo:IAO_0000115 "Wasting or decrease in size of all or part of the duodenum." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T12:20:19Z" ; oboInOwl:hasDbXref "UMLS:C4022911" ; oboInOwl:id "HP:0012414" ; a owl:Class ; rdfs:label "Duodenal atrophy" ; rdfs:subClassOf obo:HP_0002246 . obo:HP_0012415 obo:IAO_0000115 "An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T04:59:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:312391003", "UMLS:C0476337" ; oboInOwl:hasExactSynonym "Abnormal blood gas level" ; oboInOwl:id "HP:0012415" ; a owl:Class ; rdfs:label "Abnormal blood gas level" ; rdfs:subClassOf obo:HP_0002795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_138675 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012416 obo:IAO_0000115 "Abnormally elevated blood carbon dioxide (CO2) level." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T05:04:49Z" ; oboInOwl:hasDbXref "MSH:D006935", "SNOMEDCT_US:29596007", "UMLS:C0020440" ; oboInOwl:hasExactSynonym "High blood carbon dioxide level", "Hypercarbia" ; oboInOwl:id "HP:0012416" ; a owl:Class ; rdfs:label "Hypercapnia" ; rdfs:subClassOf obo:HP_0500164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012417 obo:IAO_0000115 "Abnormally reduced blood carbon dioxide (CO2) level." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T05:06:10Z" ; oboInOwl:hasDbXref "MSH:D016857", "SNOMEDCT_US:61031008", "UMLS:C0085383" ; oboInOwl:hasExactSynonym "Hypocarbia", "Reduced carbon dioxide in the blood" ; oboInOwl:id "HP:0012417" ; a owl:Class ; rdfs:label "Hypocapnia" ; rdfs:subClassOf obo:HP_0500164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012418 obo:IAO_0000115 "An abnormally low level of blood oxygen." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T05:07:07Z" ; oboInOwl:hasDbXref "MSH:D000860", "SNOMEDCT_US:389087006", "UMLS:C0700292" ; oboInOwl:hasExactSynonym "Low blood oxygen level" ; oboInOwl:hasRelatedSynonym "Hypoxia" ; oboInOwl:id "HP:0012418" ; a owl:Class ; rdfs:comment "Note that hypoxemia is defined as a condition where arterial oxygen tension is below normal (80-100mmHg). Hypoxia is defined as the failure of oxygenation at the tissue level. Hypoxia is not measured directly by a standard laboratory value." ; rdfs:label "Hypoxemia" ; rdfs:subClassOf obo:HP_0500165 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012419 obo:IAO_0000115 "An abnormally high level of blood oxygen." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T05:09:04Z" ; oboInOwl:hasDbXref "UMLS:C4022910" ; oboInOwl:id "HP:0012419" ; a owl:Class ; rdfs:comment "Note that hyperoxemia is defined as a condition where arterial oxygen tension is above normal (80-100mmHg). Hyperoxia is defined as increased oxygen tension at the tissue level. Hyperoxia is not measured directly by a standard laboratory value." ; rdfs:label "Hyperoxemia" ; rdfs:subClassOf obo:HP_0500165 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012420 obo:IAO_0000115 "Amniotic fluid containing the earliest stools of a mammalian infant." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T06:01:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:168092006", "SNOMEDCT_US:249135009", "UMLS:C0426209" ; oboInOwl:hasExactSynonym "Meconium staining of amniotic fluid", "Meconium-stained amniotic fluid" ; oboInOwl:id "HP:0012420" ; a owl:Class ; rdfs:comment "Meconium may be expelled into the amniotic fluid before birth in response to fetal distress. If meconium is aspirated by the fetus, it may lead to meconium aspiration syndrome." ; rdfs:label "Meconium stained amniotic fluid" ; rdfs:subClassOf obo:HP_0001560 . obo:HP_0012421 obo:IAO_0000115 "Congenital lack of the skin of prepuce of penis, that is, of the double-layered fold of skin and mucous membrane that covers the glans penis." ; dcterms:creator ; oboInOwl:creation_date "2013-11-10T06:17:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:300519001", "UMLS:C0577242" ; oboInOwl:hasExactSynonym "Absent foreskin", "Aposthia" ; oboInOwl:id "HP:0012421" ; a owl:Class ; rdfs:comment "Absence of the foreskin can be accompanied by Cryptorchidism and Hypospadias, which should be coded separately." ; rdfs:label "Congenital absence of foreskin" ; rdfs:subClassOf obo:HP_0100587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012422 obo:IAO_0000115 "Overgrowth of the choroid plexus." ; dcterms:creator ; oboInOwl:creation_date "2013-11-11T07:50:37Z" ; oboInOwl:hasDbXref "UMLS:C4020728", "UMLS:C4021089" ; oboInOwl:hasExactSynonym "Choroid plexus hypertrophy" ; oboInOwl:hasRelatedSynonym "Diffuse villous hypertrophy of choroid plexus" ; oboInOwl:id "HP:0012422" ; a owl:Class ; rdfs:comment "The most common location for overgrowth is the lateral ventricles. The choroid plexus folds into many villi around capillaries, creating frond-like processes that project into the ventricles. The terms choroid plexus hypertrophy or choroid plexus hyperplasia are used interchangeably to refer to an increase in size of these structures. Diffuse villous hyperplasia of choroid plexus (DVHCP) is a rare condition which is characterized by the presence of diffuse enlargement of the entire choroid plexus throughout the length of the choroidal fissure and overproduction of CSF." ; rdfs:label "Villous hypertrophy of choroid plexus" ; rdfs:subClassOf obo:HP_0007376 . obo:HP_0012423 obo:IAO_0000115 "The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days." ; dcterms:creator ; oboInOwl:creation_date "2013-11-11T08:04:46Z" ; oboInOwl:hasDbXref "MSH:D003248", "UMLS:C1257861" ; oboInOwl:id "HP:0012423" ; a owl:Class ; rdfs:label "Colonic inertia" ; rdfs:subClassOf obo:HP_0012700 . obo:HP_0012424 obo:IAO_0000115 "An inflammation of the choroid and retina." ; dcterms:creator ; oboInOwl:creation_date "2013-11-11T08:10:29Z" ; oboInOwl:hasDbXref "MSH:D002825", "SNOMEDCT_US:46627006", "UMLS:C0008513" ; oboInOwl:id "HP:0012424" ; a owl:Class ; rdfs:comment "Chorioretinitis is a form of posterior uveitis. Note that the term Chorioretinitis suggests that the origin of the process is predominantly in the choroid while Retinitis suggests that the process is mainly in the retina." ; rdfs:label "Chorioretinitis" ; rdfs:subClassOf obo:HP_0000532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0012425 obo:IAO_0000115 "An ulcer of the colon due to pressure and irritation from retained fecal masses." ; dcterms:creator ; oboInOwl:creation_date "2013-11-12T10:28:18Z" ; oboInOwl:hasBroadSynonym "Colon ulcer" ; oboInOwl:hasDbXref "SNOMEDCT_US:235766003", "SNOMEDCT_US:38084005", "SNOMEDCT_US:46040000", "UMLS:C0267491", "UMLS:C0333302" ; oboInOwl:hasRelatedSynonym "Recto-sigmoid colon stercoral ulcer" ; oboInOwl:id "HP:0012425" ; a owl:Class ; rdfs:comment "Stercoral ulceration is the loss of bowel integrity from the pressure effects of inspissated feces. The lesion usually occurs in constipated, bedridden patients and presents as an isolated lesion in the rectosigmoid area." ; rdfs:label "Stercoral ulcer" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0034274 . obo:HP_0012426 obo:IAO_0000115 "Optic disc drusen are acellular, calcified deposits within the optic nerve head. Optic disc drusen are congenital and developmental anomalies of the optic nerve head, representing hyaline-containing bodies that, over time, appear as elevated, lumpy irregularities on the anterior portion of the optic nerve." ; dcterms:creator ; oboInOwl:creation_date "2013-11-12T10:36:06Z" ; oboInOwl:hasDbXref "MSH:D015594", "SNOMEDCT_US:33629003", "UMLS:C0029128" ; oboInOwl:hasExactSynonym "Optic nerve head drusen" ; oboInOwl:id "HP:0012426" ; a owl:Class ; rdfs:comment "Optic disc drusen can lead to an elevated disc and thus mimic disc swelling (pseudopapilledema)." ; rdfs:label "Optic disc drusen" ; rdfs:subClassOf obo:HP_0011510, obo:HP_0012795 . obo:HP_0012427 obo:IAO_0000115 "An increased degree of femoral version, which is defined as the angular difference between axis of femoral neck and transcondylar axis of the knee. Thus, femoral anteversion is an inward twisting of the femur that causes the knees and feet to turn inward." ; dcterms:creator ; oboInOwl:creation_date "2013-11-12T10:51:07Z" ; oboInOwl:hasAlternativeId "HP:0031068" ; oboInOwl:hasDbXref "UMLS:C4022909" ; oboInOwl:hasExactSynonym "Excessive femoral anteversion", "Increased femoral neck anteversion", "Internally rotated hips" ; oboInOwl:id "HP:0012427" ; a owl:Class ; rdfs:comment "Femoral neck anteversion (FNA), also called femoral torsion or femoral version, is the angle between the projection of two lines in the axial plane perpendicular to the femoral shaft; one line going through the proximal femoral neck region and the second one through the distal condylar region, indicating the degree of twist of the femur. Excessive femoral anteversion is a common cause of in-toeing that first presents in early childhood. See Figure 1 of PMID:32579722." ; rdfs:label "Increased femoral anteversion" ; rdfs:subClassOf obo:HP_0031069 . obo:HP_0012428 obo:IAO_0000115 "Protruding heel bone, or calcaneus." ; dcterms:creator ; oboInOwl:creation_date "2013-11-12T11:04:49Z" ; oboInOwl:hasDbXref "UMLS:C4021088" ; oboInOwl:hasExactSynonym "Prominent heel bone" ; oboInOwl:id "HP:0012428" ; a owl:Class ; rdfs:label "Prominent calcaneus" ; rdfs:subClassOf obo:HP_0008364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012429 obo:IAO_0000115 "Absence or underdevelopment of the cerebral white matter." ; dcterms:creator ; oboInOwl:creation_date "2013-11-13T07:39:37Z" ; oboInOwl:hasDbXref "UMLS:C4021844" ; oboInOwl:hasExactSynonym "Absent/small cerebral white matter", "Absent/underdeveloped cerebral white matter" ; oboInOwl:id "HP:0012429" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the cerebral white matter" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012430 obo:IAO_0000115 "Underdevelopment of the cerebral white matter." ; dcterms:creator ; oboInOwl:creation_date "2013-11-13T07:42:02Z" ; oboInOwl:hasDbXref "UMLS:C4020727", "UMLS:C4022908" ; oboInOwl:hasRelatedSynonym "Paucity of cerebral white matter" ; oboInOwl:id "HP:0012430" ; a owl:Class ; rdfs:label "Cerebral white matter hypoplasia" ; rdfs:subClassOf obo:HP_0012429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012431 obo:IAO_0000115 "Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation." ; dcterms:creator ; oboInOwl:creation_date "2013-11-13T07:45:40Z" ; oboInOwl:hasDbXref "UMLS:C4022907" ; oboInOwl:id "HP:0012431" ; a owl:Class ; rdfs:label "Episodic fatigue" ; rdfs:subClassOf obo:HP_0012378 . obo:HP_0012432 obo:IAO_0000115 "Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer." ; dcterms:creator ; oboInOwl:creation_date "2013-11-13T07:49:08Z" ; oboInOwl:hasDbXref "UMLS:C0518656" ; oboInOwl:hasExactSynonym "Chronic extreme exhaustion", "Chronic fatigue" ; oboInOwl:id "HP:0012432" ; a owl:Class ; rdfs:comment "Note that chronic fatigue can be a symptom of chronic fatigue syndrome (CFS), which is characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms of CFS may include weakness, muscle pain, impaired memory, impaired mental concentration, and insomnia, which can result in reduced participation in daily activities." ; rdfs:label "Chronic fatigue" ; rdfs:subClassOf obo:HP_0012378 . obo:HP_0012433 obo:IAO_0000115 "An abnormality of actions or reactions of a person taking place during interactions with others." ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T08:37:01Z" ; oboInOwl:hasDbXref "UMLS:C4020726", "UMLS:C4021087" ; oboInOwl:hasExactSynonym "Abnormal social behavior", "Abnormal social behaviour", "Abnormal social interactions" ; oboInOwl:id "HP:0012433" ; a owl:Class ; rdfs:label "Abnormal social behavior" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0012434 obo:IAO_0000115 "A failure to meet one or more age-related milestones of social behavior." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T08:40:29Z" ; oboInOwl:hasDbXref "UMLS:C4022906" ; oboInOwl:hasExactSynonym "Delayed social development" ; oboInOwl:id "HP:0012434" ; a owl:Class ; rdfs:comment "This term should be applied to describe a child whose social development is delayed compared to age-related norms. For instance, at the age of 3 months, a child smiles in response to social interaction, at the age of 7 months, a child responds to the facial expressions of others, and at the age of 12 months a child is shy around strangers." ; rdfs:label "Delayed social development" ; rdfs:subClassOf obo:HP_0012433, obo:HP_0012758 . obo:HP_0012435 obo:IAO_0000115 "Reduction in length of the ventral (lower) skin of prepuce of penis." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T08:45:20Z" ; oboInOwl:hasDbXref "UMLS:C4022905" ; oboInOwl:id "HP:0012435" ; a owl:Class ; rdfs:label "Ventral shortening of foreskin" ; rdfs:subClassOf obo:HP_0100587 . obo:HP_0012436 obo:IAO_0000115 "Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T08:50:05Z" ; oboInOwl:hasDbXref "UMLS:C4020724", "UMLS:C4020725" ; oboInOwl:hasExactSynonym "Non-occlusive coronary artery disease" ; oboInOwl:hasRelatedSynonym "Non-occlusive coronary artery stenosis", "Nonocclusive coronary artery disease", "Nonocclusive coronary artery stenosis" ; oboInOwl:id "HP:0012436" ; a owl:Class ; rdfs:label "Nonocclusive coronary artery atherosclerosis" ; rdfs:subClassOf obo:HP_0001677 . obo:HP_0012437 obo:IAO_0000115 "A structural anomaly of the gallbladder." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T01:13:40Z" ; oboInOwl:hasDbXref "UMLS:C4022904" ; oboInOwl:hasExactSynonym "Abnormal gallbladder structure", "Abnormal shape of gallbladder" ; oboInOwl:id "HP:0012437" ; a owl:Class ; rdfs:label "Abnormal gallbladder morphology" ; rdfs:subClassOf obo:HP_0005264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012438 obo:IAO_0000115 "A functional anomaly of the gallbladder." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T01:17:00Z" ; oboInOwl:hasDbXref "UMLS:C4022903" ; oboInOwl:id "HP:0012438" ; a owl:Class ; rdfs:label "Abnormal gallbladder physiology" ; rdfs:subClassOf obo:HP_0005264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012439 obo:IAO_0000115 "A functional abnormality of the biliary tree." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:14:51Z" ; oboInOwl:hasDbXref "UMLS:C4022902" ; oboInOwl:id "HP:0012439" ; a owl:Class ; rdfs:label "Abnormal biliary tract physiology" ; rdfs:subClassOf obo:HP_0001080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012440 obo:IAO_0000115 "A structural abnormality of the biliary tree." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:15:33Z" ; oboInOwl:hasDbXref "UMLS:C4021086" ; oboInOwl:hasExactSynonym "Anomaly of the biliary tract" ; oboInOwl:id "HP:0012440" ; a owl:Class ; rdfs:label "Abnormal biliary tract morphology" ; rdfs:subClassOf obo:HP_0001080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012441 obo:IAO_0000115 "Reduced motility through the sphincter of Oddi, resulting in impedance of bile and pancreatic juice flow from the common bile duct into the duodenum." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:21:59Z" ; oboInOwl:hasDbXref "MSH:D046628", "SNOMEDCT_US:430887001", "UMLS:C0878588", "UMLS:C4048750" ; oboInOwl:hasRelatedSynonym "Sphincter of Oddi dysfunction" ; oboInOwl:id "HP:0012441" ; a owl:Class ; rdfs:comment "The sphincter of Oddi (also known as sphincter of ampulla) is a muscular valve that controls the flow of bile and pancreatic juice through the ampulla of Vater into the second part of the duodenum. Increased tone of the sphincter or disturbance in the coordination of contraction of the biliary ducts prevents normal emptying of the biliary tree. This may result in biliary pain, common bile duct dilation and episodes of pancreatitis." ; rdfs:label "Sphincter of Oddi dyskinesia" ; rdfs:subClassOf obo:HP_0012396 . obo:HP_0012442 obo:IAO_0000115 "Reduced motility of the gallbladder with reduced emptying fraction." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:28:07Z" ; oboInOwl:hasDbXref "MSH:D001657", "UMLS:C1449631" ; oboInOwl:id "HP:0012442" ; a owl:Class ; rdfs:comment "Patients with this gallbladder dyskinesia present with biliary-type pain but no evidence of gallstones in the gallbladder. The diagnosis is made by performing a radionuclide investigation of the gallbladder ejection fraction. An abnormal gallbladder ejection fraction has a value less than 40 percent." ; rdfs:label "Gallbladder dyskinesia" ; rdfs:subClassOf obo:HP_0012396 . obo:HP_0012443 obo:IAO_0000115 "A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:38:00Z" ; oboInOwl:hasDbXref "UMLS:C4021085" ; oboInOwl:hasExactSynonym "Abnormal shape of brain", "Abnormality of the brain" ; oboInOwl:id "HP:0012443" ; a owl:Class ; rdfs:label "Abnormality of brain morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012444 obo:IAO_0000115 "Partial or complete wasting (loss) of brain tissue that was once present." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T02:46:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:278849000", "SNOMEDCT_US:418143002", "SNOMEDCT_US:52522001", "UMLS:C0154671", "UMLS:C0235946" ; oboInOwl:hasExactSynonym "Brain degeneration", "Brain wasting" ; oboInOwl:id "HP:0012444" ; a owl:Class ; rdfs:label "Brain atrophy" ; rdfs:subClassOf obo:HP_0007367, obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012446 obo:IAO_0000115 "A reduced concentration of 5-methyltetrahydrofolate(2-) in the cerebrospinal fluid (CSF). 5-methyltetrahydrofolate is the active folate metabolite." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T03:40:41Z" ; oboInOwl:hasAlternativeId "HP:0012336" ; oboInOwl:hasDbXref "MSH:C567791", "SNOMEDCT_US:711403001", "UMLS:C2751584", "UMLS:C4022901" ; oboInOwl:hasExactSynonym "Low CSF 5-methyltetrahydrofolate", "Reduced CSF 5-methyltetrahydrofolate concentration" ; oboInOwl:hasRelatedSynonym "Cerebral folate deficiency" ; oboInOwl:id "HP:0012446" ; a owl:Class ; rdfs:label "Decreased CSF 5-methyltetrahydrofolate concentration" ; rdfs:subClassOf obo:HP_0012335, obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_20612 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012447 obo:IAO_0000115 "Any anomaly in the process by which myelin sheaths are formed and maintained around neurons." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T03:45:58Z" ; oboInOwl:hasDbXref "UMLS:C1857704" ; oboInOwl:id "HP:0012447" ; a owl:Class ; rdfs:label "Abnormal myelination" ; rdfs:subClassOf obo:HP_0012639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012448 obo:IAO_0000115 "Delayed myelination." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T03:47:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:135810007", "UMLS:C1277241" ; oboInOwl:id "HP:0012448" ; a owl:Class ; rdfs:label "Delayed myelination" ; rdfs:subClassOf obo:HP_0012447 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012449 obo:IAO_0000115 "Inflammation of the synovial membrane of the sacroiliac joint." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T03:54:32Z" ; oboInOwl:hasDbXref "UMLS:C4022900" ; oboInOwl:id "HP:0012449" ; a owl:Class ; rdfs:label "Sacroiliac joint synovitis" ; rdfs:subClassOf obo:HP_0100781 . obo:HP_0012450 obo:IAO_0000115 "Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T04:03:43Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:236069009", "UMLS:C0401149" ; oboInOwl:hasExactSynonym "Chronic constipation", "Infrequent bowel movements" ; oboInOwl:id "HP:0012450" ; a owl:Class ; rdfs:label "Chronic constipation" ; rdfs:subClassOf obo:HP_0002019 . obo:HP_0012451 obo:IAO_0000115 "Constipation of sudden onset and lasting for less than three months." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T04:06:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:197119006", "UMLS:C0401148" ; oboInOwl:id "HP:0012451" ; a owl:Class ; rdfs:label "Acute constipation" ; rdfs:subClassOf obo:HP_0002019 . obo:HP_0012452 obo:IAO_0000115 "A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T07:42:59Z" ; oboInOwl:hasDbXref "MSH:D012148", "SNOMEDCT_US:32914008", "UMLS:C0035258" ; oboInOwl:hasRelatedSynonym "Restless legs syndrome", "Willis-Ekbom disease", "Wittmaack-Ekbom syndrome" ; oboInOwl:id "HP:0012452" ; a owl:Class ; rdfs:comment "Restless legs syndrome is a disorder characterized by aching or burning sensations in the legs that occur prior to sleep or may awaken the affected persons. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence." ; rdfs:label "Restless legs" ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0012453 obo:IAO_0000115 "A chronic loss of wrist joint motion on the right and left sides." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T07:58:50Z" ; oboInOwl:hasDbXref "UMLS:C4020723", "UMLS:C4022899" ; oboInOwl:hasRelatedSynonym "Bilateral wrist contracture" ; oboInOwl:id "HP:0012453" ; a owl:Class ; rdfs:label "Bilateral wrist flexion contracture" ; rdfs:subClassOf obo:HP_0001239 . obo:HP_0012454 obo:IAO_0000115 "A chronic loss of wrist joint motion on one side only." ; dcterms:creator ; oboInOwl:creation_date "2013-11-23T07:59:39Z" ; oboInOwl:hasDbXref "UMLS:C4020722", "UMLS:C4022898" ; oboInOwl:hasRelatedSynonym "Unilateral wrist contracture" ; oboInOwl:id "HP:0012454" ; a owl:Class ; rdfs:label "Unilateral wrist flexion contracture" ; rdfs:subClassOf obo:HP_0001239 . obo:HP_0012455 obo:IAO_0100001 "HP:0003207" ; oboInOwl:id "HP:0012455" ; a owl:Class ; rdfs:label "obsolete Large artery calcification" ; owl:deprecated true . obo:HP_0012456 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the tunica media of arteries." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T10:50:45Z" ; oboInOwl:hasDbXref "UMLS:C4022896" ; oboInOwl:id "HP:0012456" ; a owl:Class ; rdfs:comment "Medial arterial calcification causes stiffening and decreased compliance of the affected arteries." ; rdfs:label "Medial arterial calcification" ; rdfs:subClassOf obo:HP_0003207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007239 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012457 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the tunica media of medium-sized (muscular or distributive) arteries." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T11:11:13Z" ; oboInOwl:hasDbXref "UMLS:C4022895" ; oboInOwl:id "HP:0012457" ; a owl:Class ; rdfs:comment "GitHub issue: https://github.com/obophenotype/human-phenotype-ontology/issues/6877" ; rdfs:label "Medial calcification of medium-sized arteries" ; rdfs:subClassOf obo:HP_0012456 . obo:HP_0012458 obo:IAO_0000115 "Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T11:13:13Z" ; oboInOwl:hasDbXref "UMLS:C4022894" ; oboInOwl:id "HP:0012458" ; a owl:Class ; rdfs:comment "The general construction of small arteries is very similar to that of muscular arteries. The media is still muscular and has up to 8-10 layers of smooth muscle cells. A discussion on the logical definition can be found here: https://github.com/obophenotype/human-phenotype-ontology/issues/6877." ; rdfs:label "Medial calcification of small arteries" ; rdfs:subClassOf obo:HP_0012456 . obo:HP_0012459 obo:IAO_0000115 "A headache disorder that occurs exclusively at night, waking the affected individual from sleep." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T11:20:18Z" ; oboInOwl:hasDbXref "MSH:D051270", "SNOMEDCT_US:122711000119109", "UMLS:C0752150" ; oboInOwl:hasExactSynonym "Alarm clock headache" ; oboInOwl:id "HP:0012459" ; a owl:Class ; rdfs:comment "Hypnic headache can be unilateral or bilateral, and is often but not always described as throbbing. The pain begins abruptly and can last from 15 minutes to 6 hours, although typically it is about 30-60 minutes." ; rdfs:label "Hypnic headache" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0012460 obo:IAO_0000115 "A structural anomaly of the inferior portion of the vermis of cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T11:59:06Z" ; oboInOwl:hasDbXref "UMLS:C4022893" ; oboInOwl:id "HP:0012460" ; a owl:Class ; rdfs:label "Dysmorphic inferior cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334 . obo:HP_0012461 obo:IAO_0000115 "The presence of bacteria in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T12:15:47Z" ; oboInOwl:hasDbXref "MSH:D001437", "SNOMEDCT_US:61373006", "UMLS:C0004659" ; oboInOwl:hasExactSynonym "Bacteria in urine", "High urine bacteria" ; oboInOwl:id "HP:0012461" ; a owl:Class ; rdfs:comment "The urine is normally bacteria-free. The term refers to bacteria from the urinary tract and not to bacteria found in the urine because of contamination from the surrounding tissues. Significant bacteriuria is a sign of urinary tract infection." ; rdfs:label "Bacteriuria" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0012462 obo:IAO_0000115 "Involuntary and irregular twitches of the chin." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T12:26:38Z" ; oboInOwl:hasDbXref "MSH:C537682", "UMLS:C1860972" ; oboInOwl:hasExactSynonym "Geniospasm" ; oboInOwl:hasRelatedSynonym "Chin spasms" ; oboInOwl:id "HP:0012462" ; a owl:Class ; rdfs:label "Chin myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0012463 obo:IAO_0000115 "An above normal level of saturation of serum transferrin with iron." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T12:46:56Z" ; oboInOwl:hasDbXref "UMLS:C4022892" ; oboInOwl:id "HP:0012463" ; a owl:Class ; rdfs:comment "Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. The transferrin saturation test (TSAT) refers to the ratio of serum iron to total iron-binding capacity, expressed as a percentage. Transferrin saturations of less than 20% indicate iron deficiency, while transferrin saturations of more than 50% suggest iron overload. Note that the results of the TSAT can be influenced by inflammation." ; rdfs:label "Elevated transferrin saturation" ; rdfs:subClassOf obo:HP_0040135 . obo:HP_0012464 obo:IAO_0000115 "A below normal level of saturation of serum transferrin with iron." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T12:51:51Z" ; oboInOwl:hasDbXref "UMLS:C0919785" ; oboInOwl:id "HP:0012464" ; a owl:Class ; rdfs:comment "Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. The transferrin saturation test (TSAT) refers to the ratio of serum iron to total iron-binding capacity, expressed as a percentage. Transferrin saturations of less than 20% indicate iron deficiency, while transferrin saturations of more than 50% suggest iron overload. Note that the results of the TSAT can be influenced by inflammation." ; rdfs:label "Decreased transferrin saturation" ; rdfs:subClassOf obo:HP_0040135 . obo:HP_0012465 obo:IAO_0000115 "An increased level of iron in liver tissues." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T12:54:57Z" ; oboInOwl:hasDbXref "UMLS:C4022891" ; oboInOwl:hasExactSynonym "Increased iron concentration in liver", "Increased liver iron level" ; oboInOwl:id "HP:0012465" ; a owl:Class ; rdfs:comment "This abnormality can be measured by liver biopsy or by hepatic magnetic resonance imaging." ; rdfs:label "Elevated hepatic iron concentration" ; rdfs:subClassOf obo:HP_0040134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012466 obo:IAO_0000115 "Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T01:11:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:8764008", "UMLS:C0268048" ; oboInOwl:id "HP:0012466" ; a owl:Class ; rdfs:label "Chronic respiratory acidosis" ; rdfs:subClassOf obo:HP_0005972, obo:HP_0012468 . obo:HP_0012467 obo:IAO_0000115 "Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T01:11:51Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:70644008", "UMLS:C0268047" ; oboInOwl:id "HP:0012467" ; a owl:Class ; rdfs:label "Acute respiratory acidosis" ; rdfs:subClassOf obo:HP_0005972 . obo:HP_0012468 obo:IAO_0000115 "Longstanding abnormal acid accumulation or depletion of base." ; dcterms:creator ; oboInOwl:creation_date "2013-11-24T01:16:31Z" ; oboInOwl:hasDbXref "UMLS:C1735903" ; oboInOwl:id "HP:0012468" ; a owl:Class ; rdfs:label "Chronic acidosis" ; rdfs:subClassOf obo:HP_0001941 . obo:HP_0012469 obo:IAO_0000115 "Infantile spasms represent a subset of \"epileptic spasms\". Infantile Spasms are epileptic spasms starting in the first year of life (infancy)." ; dcterms:creator ; oboInOwl:creation_date "2013-11-26T05:36:45Z" ; oboInOwl:hasDbXref "UMLS:C3887898" ; oboInOwl:id "HP:0012469" ; a owl:Class ; rdfs:label "Infantile spasms" ; rdfs:subClassOf obo:HP_0011097 . obo:HP_0012470 obo:IAO_0000115 "An ophthalmologic sign in young children resulting from upward-gaze paresis. In this condition, the eyes appear driven downward, the sclera may be seen between the upper eyelid and the iris, and part of the lower pupil may be covered by the lower eyelid." ; dcterms:creator ; oboInOwl:creation_date "2013-11-26T05:40:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:63342001", "UMLS:C0423128", "UMLS:C4020721" ; oboInOwl:hasExactSynonym "Setting-sun eye phenomenon", "Sun setting eyes", "Sunsetting eye" ; oboInOwl:hasRelatedSynonym "Eyes fixed downward" ; oboInOwl:id "HP:0012470" ; a owl:Class ; rdfs:comment "Setting-sun eye phenomenon can also be transiently elicited in healthy infants up to 7 months of age by changes of position or removal of light (benign setting-sun phenomenon). When persistent, this sign is one of the most frequent markers of elevated intracranial pressure." ; rdfs:label "Setting-sun eye phenomenon" ; rdfs:subClassOf obo:HP_0000597 . obo:HP_0012471 obo:IAO_0000115 "Increased width of the skin of vermilion border region of upper lip." ; dcterms:creator ; oboInOwl:creation_date "2013-11-26T09:07:51Z" ; oboInOwl:hasDbXref "UMLS:C1836543" ; oboInOwl:hasExactSynonym "Full lips", "Increased volume of lip", "Increased volume of lip vermillion", "Plump lips", "Prominent lips", "Thick lips" ; oboInOwl:id "HP:0012471" ; a owl:Class ; rdfs:label "Thick vermilion border" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0012472 obo:IAO_0000115 "A turning outward of the lip or lips, that is, eversion of the lips." ; dcterms:creator ; oboInOwl:creation_date "2013-11-26T10:20:23Z" ; oboInOwl:hasDbXref "UMLS:C3550430" ; oboInOwl:hasExactSynonym "Eclabium", "Everted lips", "Outward turned lips" ; oboInOwl:id "HP:0012472" ; a owl:Class ; rdfs:label "Eclabion" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0012473 obo:IAO_0000115 "Wasting of the tongue." ; dcterms:creator ; oboInOwl:creation_date "2013-11-26T10:32:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249382006", "SNOMEDCT_US:50805004", "UMLS:C0241423", "UMLS:C0426494" ; oboInOwl:hasExactSynonym "Atrophy of the tongue", "Lingual atrophy", "Lingual wasting", "Wasting of the tongue" ; oboInOwl:id "HP:0012473" ; a owl:Class ; rdfs:label "Tongue atrophy" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0012474 obo:IAO_0000115 "Complete obstruction of a carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2013-11-27T10:11:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:266254007", "SNOMEDCT_US:69798007", "UMLS:C0265101" ; oboInOwl:hasExactSynonym "Obstructed carotid artery" ; oboInOwl:id "HP:0012474" ; a owl:Class ; rdfs:comment "Carotid artery occlusion is usually caused by caused by atherosclerosis." ; rdfs:label "Carotid artery occlusion" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0012475 obo:IAO_0000115 "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against a specific antigen or microorganism." ; dcterms:creator ; oboInOwl:creation_date "2013-11-27T10:21:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:234556002", "UMLS:C0398711" ; oboInOwl:hasExactSynonym "Abnormal specific antibody response", "Decreased specific antibody in blood", "Specific antibody deficiency" ; oboInOwl:id "HP:0012475" ; a owl:Class ; rdfs:label "Decreased circulating level of specific antibody" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0031404 . obo:HP_0012476 obo:IAO_0000115 "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci." ; dcterms:creator ; oboInOwl:creation_date "2013-11-27T10:28:04Z" ; oboInOwl:hasDbXref "UMLS:C4022890" ; oboInOwl:hasExactSynonym "Low pneumococcal antibody titer", "Specific pneumococcal antibody deficiency" ; oboInOwl:id "HP:0012476" ; a owl:Class ; rdfs:label "Decreased specific pneumococcal antibody level" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0012477 obo:IAO_0000115 "A wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T07:11:37Z" ; oboInOwl:hasDbXref "UMLS:C4022889" ; oboInOwl:hasExactSynonym "Shakey voice", "Vocal tremor" ; oboInOwl:id "HP:0012477" ; a owl:Class ; rdfs:label "Vocal tremor" ; rdfs:subClassOf obo:HP_0002345 . obo:HP_0012478 obo:IAO_0000115 "Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T07:24:24Z" ; oboInOwl:hasDbXref "MSH:C536957", "SNOMEDCT_US:298231004", "SNOMEDCT_US:50603008", "SNOMEDCT_US:91866004", "UMLS:C0575010", "UMLS:C0685924", "UMLS:C2931375" ; oboInOwl:hasExactSynonym "Ankylosis of temporomandibular joint", "Freezing of jaw joint", "Freezing of the temporomandibular joint", "Rigidity of the temporomandibular joint", "Temporomandibular joint fusion" ; oboInOwl:hasNarrowSynonym "Adhesion of the temporomandibular joint" ; oboInOwl:id "HP:0012478" ; a owl:Class ; rdfs:label "Temporomandibular joint ankylosis" ; rdfs:subClassOf obo:HP_0010754 . obo:HP_0012479 obo:IAO_0000115 "Noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T07:28:13Z" ; oboInOwl:hasBroadSynonym "Jaw joint noise", "Jaw joint sounds", "Temporomandibular joint noise", "Temporomandibular joint sounds" ; oboInOwl:hasDbXref "SNOMEDCT_US:298377005", "UMLS:C0575154", "UMLS:C4280313", "UMLS:C4280314", "UMLS:C4280315" ; oboInOwl:hasExactSynonym "Jaw joint crepitus" ; oboInOwl:hasNarrowSynonym "Jaw joint clicking sound", "Jaw joint grating sound", "Jaw joint popping sound", "Temporomandibular joint clicking sound", "Temporomandibular joint grating sound", "Temporomandibular joint popping sound" ; oboInOwl:id "HP:0012479" ; a owl:Class ; rdfs:label "Temporomandibular joint crepitus" ; rdfs:subClassOf obo:HP_0010754 . obo:HP_0012480 obo:IAO_0000115 "An anomaly of cerebral veins." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T08:01:32Z" ; oboInOwl:hasDbXref "UMLS:C4022888" ; oboInOwl:hasExactSynonym "Abnormality of cerebral veins" ; oboInOwl:id "HP:0012480" ; a owl:Class ; rdfs:label "Abnormal cerebral vein morphology" ; rdfs:subClassOf obo:HP_0100659 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001663 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012481 obo:IAO_0000115 "A congenital malformation of veins which drain normal brain characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T08:03:08Z" ; oboInOwl:hasDbXref "MSH:D020787", "UMLS:C1956261" ; oboInOwl:hasExactSynonym "Developmental Venous Anomaly" ; oboInOwl:id "HP:0012481" ; a owl:Class ; rdfs:comment "DVA is characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system." ; rdfs:label "Cerebral venous angioma" ; rdfs:subClassOf obo:HP_0012480 . obo:HP_0012482 obo:IAO_0000115 "A venous angioma of the frontal lobe of the brain." ; dcterms:creator ; oboInOwl:creation_date "2013-11-28T08:12:07Z" ; oboInOwl:hasDbXref "UMLS:C4022887" ; oboInOwl:id "HP:0012482" ; a owl:Class ; rdfs:label "Frontal venous angioma" ; rdfs:subClassOf obo:HP_0012481 . obo:HP_0012483 obo:IAO_0000115 "Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T07:44:49Z" ; oboInOwl:hasDbXref "UMLS:C4022886" ; oboInOwl:id "HP:0012483" ; a owl:Class ; rdfs:comment "This feature can be observed by electron microscopy. Alpha granules normally contain a number of proteins including von Willebrand factor, and fibrinogen." ; rdfs:label "Abnormal alpha granules" ; rdfs:subClassOf obo:HP_0011883 . obo:HP_0012484 obo:IAO_0000115 "Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T07:48:08Z" ; oboInOwl:hasDbXref "UMLS:C4022885" ; oboInOwl:id "HP:0012484" ; a owl:Class ; rdfs:comment "This feature can be observed by electron microscopy." ; rdfs:label "Abnormal dense granules" ; rdfs:subClassOf obo:HP_0011883 . obo:HP_0012485 obo:IAO_0000115 "An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T07:55:15Z" ; oboInOwl:hasDbXref "UMLS:C4021840" ; oboInOwl:id "HP:0012485" ; a owl:Class ; rdfs:label "Abnormal surface-connected open canalicular system" ; rdfs:subClassOf obo:HP_0011875 . obo:HP_0012486 obo:IAO_0000115 "Inflammation of the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T08:10:12Z" ; oboInOwl:hasDbXref "MSH:D009187", "SNOMEDCT_US:41370002", "UMLS:C0026975" ; oboInOwl:hasExactSynonym "Inflammation of spinal cord" ; oboInOwl:id "HP:0012486" ; a owl:Class ; rdfs:label "Myelitis" ; rdfs:subClassOf obo:HP_0002143, obo:HP_0033429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012487 obo:IAO_0000115 "An arachnoid cyst located at the margin of the cerebellum and pons." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T09:03:39Z" ; oboInOwl:hasDbXref "UMLS:C4022884" ; oboInOwl:id "HP:0012487" ; a owl:Class ; rdfs:comment "The cerebellopontine angle is in the posterior fossa." ; rdfs:label "Cerebellopontine angle arachnoid cyst" ; rdfs:subClassOf obo:HP_0007291, obo:HP_0100702 . obo:HP_0012488 obo:IAO_0000115 "An arachnoid cyst located within the ventricular system." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T09:08:46Z" ; oboInOwl:hasDbXref "UMLS:C4022883" ; oboInOwl:id "HP:0012488" ; a owl:Class ; rdfs:comment "Arachnoid cysts very rarely occur within the ventricular system, where no arachnoid tissue exists." ; rdfs:label "Intraventricular arachnoid cyst" ; rdfs:subClassOf obo:HP_0010576, obo:HP_0100702 . obo:HP_0012489 obo:IAO_0000115 "An arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T09:11:20Z" ; oboInOwl:hasDbXref "UMLS:C4022882" ; oboInOwl:id "HP:0012489" ; a owl:Class ; rdfs:comment "As the cyst increases in size it fills and occludes the third ventricle, and distorts and blocks the aqueduct, which finally results in hydrocephalus." ; rdfs:label "Suprasellar arachnoid cyst" ; rdfs:subClassOf obo:HP_0010576, obo:HP_0100702 . obo:HP_0012490 obo:IAO_0000115 "Inflammation of adipose tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T09:28:11Z" ; oboInOwl:hasDbXref "MSH:D015434", "SNOMEDCT_US:22125009", "UMLS:C0030326" ; oboInOwl:hasExactSynonym "Inflammation of adipose tissue", "Inflammation of fat tissue" ; oboInOwl:id "HP:0012490" ; a owl:Class ; rdfs:comment "Panniculitis most commonly affects the skin and characterized by reddened subcutaneous nodules." ; rdfs:label "Panniculitis" ; rdfs:subClassOf obo:HP_0009124, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001013 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012491 obo:IAO_0000115 "An anomaly of the intracellular membrane complexes known as the dense tubular system." ; dcterms:creator ; oboInOwl:creation_date "2013-11-29T09:35:44Z" ; oboInOwl:hasDbXref "UMLS:C4022881" ; oboInOwl:id "HP:0012491" ; a owl:Class ; rdfs:comment "The dense tubular system (DTS) functions to regulate platelet activation by sequestering or releasing calcium, similar to the sarcotubules of skeletal muscle. In resting platelets, the DTS exists as thin elongated membranes. Within 10 seconds of the addition of thrombin, platelets show a major ultrastructural change in their DTS: from the thin elongated form to a rounded vesicular form." ; rdfs:label "Abnormal dense tubular system" ; rdfs:subClassOf obo:HP_0011875 . obo:HP_0012492 obo:IAO_0000115 "Narrowing or constriction of the inner surface (lumen) of a cerebral artery." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:00:55Z" ; oboInOwl:hasDbXref "UMLS:C1504438" ; oboInOwl:hasExactSynonym "Narrowing of a cerebral artery" ; oboInOwl:id "HP:0012492" ; a owl:Class ; rdfs:label "Cerebral artery stenosis" ; rdfs:subClassOf obo:HP_0009145 . obo:HP_0012493 obo:IAO_0000115 "Narrowing or constriction of the inner surface (lumen) of the middle cerebral artery." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:04:27Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:21290001000004104", "UMLS:C1504568" ; oboInOwl:id "HP:0012493" ; a owl:Class ; rdfs:label "Middle cerebral artery stenosis" ; rdfs:subClassOf obo:HP_0012492 . obo:HP_0012494 obo:IAO_0000115 "Narrowing or constriction of the inner surface (lumen) of the anterior cerebral artery." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:06:15Z" ; oboInOwl:hasDbXref "UMLS:C1504567" ; oboInOwl:id "HP:0012494" ; a owl:Class ; rdfs:label "Anterior cerebral artery stenosis" ; rdfs:subClassOf obo:HP_0012492 . obo:HP_0012495 obo:IAO_0000115 "Narrowing or constriction of the inner surface (lumen) of the posterior cerebral artery." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:07:04Z" ; oboInOwl:hasDbXref "UMLS:C1504569" ; oboInOwl:id "HP:0012495" ; a owl:Class ; rdfs:label "Posterior cerebral artery stenosis" ; rdfs:subClassOf obo:HP_0012492 . obo:HP_0012496 obo:IAO_0000115 "A decrease in the maximum amount of negative pressure a person can generate during an inhalation." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:24:33Z" ; oboInOwl:hasDbXref "UMLS:C4022880" ; oboInOwl:id "HP:0012496" ; a owl:Class ; rdfs:label "Reduced maximal inspiratory pressure" ; rdfs:subClassOf obo:HP_0004347 . obo:HP_0012497 obo:IAO_0000115 "A decrease in the maximum amount of pressure of expired air achieved by a person after a full inspiration." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:28:49Z" ; oboInOwl:hasDbXref "UMLS:C4022879" ; oboInOwl:id "HP:0012497" ; a owl:Class ; rdfs:label "Reduced maximal expiratory pressure" ; rdfs:subClassOf obo:HP_0004347 . obo:HP_0012498 obo:IAO_0000115 "A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:32:27Z" ; oboInOwl:hasDbXref "MSH:D053589", "SNOMEDCT_US:302929008", "UMLS:C0405124" ; oboInOwl:id "HP:0012498" ; a owl:Class ; rdfs:label "Nuchal cord" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0012499 obo:IAO_0000115 "A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T08:44:18Z" ; oboInOwl:hasDbXref "UMLS:C4022878" ; oboInOwl:hasExactSynonym "Type B aortic dissection" ; oboInOwl:id "HP:0012499" ; a owl:Class ; rdfs:comment "According to the Stanford classification, type B aortic dissection begins beyond brachiocephalic vessels (begins distal to the left subclavian artery)." ; rdfs:label "Descending aortic dissection" ; rdfs:subClassOf obo:HP_0002647 . obo:HP_0012500 obo:IAO_0000115 "A wartlike (with multiple small elevated projections) papule." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:03:16Z" ; oboInOwl:hasDbXref "UMLS:C4022877" ; oboInOwl:hasExactSynonym "Papillomatous papule" ; oboInOwl:id "HP:0012500" ; a owl:Class ; rdfs:label "Verrucous papule" ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0012501 obo:IAO_0000115 "An anomaly of the white matter of brainstem." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:19:46Z" ; oboInOwl:hasDbXref "UMLS:C4022876" ; oboInOwl:hasExactSynonym "Abnormality of the brainstem white matter" ; oboInOwl:id "HP:0012501" ; a owl:Class ; rdfs:label "Abnormal brainstem white matter morphology" ; rdfs:subClassOf obo:HP_0002363 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014891 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012502 obo:IAO_0000115 "An anomaly of the internal capsule, which is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the putamen and the globus pallidus." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:29:18Z" ; oboInOwl:hasDbXref "UMLS:C4022875" ; oboInOwl:id "HP:0012502" ; a owl:Class ; rdfs:label "Abnormality of the internal capsule" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012503 obo:IAO_0000115 "An anomaly of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:34:21Z" ; oboInOwl:hasDbXref "MSH:D010900", "SNOMEDCT_US:399244003", "UMLS:C0032002" ; oboInOwl:hasExactSynonym "Abnormality of the pituitary gland", "disorder of pituitary gland" ; oboInOwl:id "HP:0012503" ; a owl:Class ; rdfs:label "Abnormal pituitary gland morphology" ; rdfs:subClassOf obo:HP_0000864, obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012504 obo:IAO_0000115 "A deviation from the normal size of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:36:04Z" ; oboInOwl:hasDbXref "UMLS:C4022874" ; oboInOwl:id "HP:0012504" ; a owl:Class ; rdfs:label "Abnormal size of pituitary gland" ; rdfs:subClassOf obo:HP_0012503 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012505 obo:IAO_0000115 "An abnormally increased size of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:36:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237718009", "UMLS:C0342422" ; oboInOwl:id "HP:0012505" ; a owl:Class ; rdfs:label "Enlarged pituitary gland" ; rdfs:subClassOf obo:HP_0012504 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012506 obo:IAO_0000115 "An abnormally decreased size of the pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2013-11-30T09:37:34Z" ; oboInOwl:hasDbXref "UMLS:C4022873" ; oboInOwl:id "HP:0012506" ; a owl:Class ; rdfs:label "Small pituitary gland" ; rdfs:subClassOf obo:HP_0012504 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012507 obo:IAO_0000115 "Reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T08:12:54Z" ; oboInOwl:hasDbXref "UMLS:C1839030" ; oboInOwl:hasExactSynonym "Weakness of orbicularis oculi muscles" ; oboInOwl:id "HP:0012507" ; a owl:Class ; rdfs:label "Weakness of orbicularis oculi muscle" ; rdfs:subClassOf obo:HP_0001324, obo:HP_0030319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001578 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012508 obo:IAO_0000115 "A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T08:21:46Z" ; oboInOwl:hasDbXref "MSH:D014786", "SNOMEDCT_US:42134006", "UMLS:C0271185" ; oboInOwl:id "HP:0012508" ; a owl:Class ; rdfs:label "Metamorphopsia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0012509 obo:IAO_0000115 "An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T08:25:46Z" ; oboInOwl:hasDbXref "UMLS:C4022872" ; oboInOwl:id "HP:0012509" ; a owl:Class ; rdfs:comment "Thyroxin-binding globulin is known as serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (SERPINA7), Entrez Gene ID 6906. Individuals with TBG deficiency are euthyroid." ; rdfs:label "Reduced thyroxin-binding globulin" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0012510 obo:IAO_0000115 "An increased amount of cerebrospinal fluid (CSF) in the subarachnoid space." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T08:37:34Z" ; oboInOwl:hasDbXref "UMLS:C4022871" ; oboInOwl:hasExactSynonym "Extra-axial CSF accumulation" ; oboInOwl:id "HP:0012510" ; a owl:Class ; rdfs:label "Extra-axial cerebrospinal fluid accumulation" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0012511 obo:IAO_0000115 "A pale yellow discoloration of the temporal (lateral) portion of the optic disc." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T08:55:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:247220006", "UMLS:C0344299" ; oboInOwl:id "HP:0012511" ; a owl:Class ; rdfs:comment "Temporal pallor is seen in conditions that selectively affect the papillo-macular bundle. The word temporal refers to the temporal bone at the side of the head." ; rdfs:label "Temporal optic disc pallor" ; rdfs:subClassOf obo:HP_0000543 . obo:HP_0012512 obo:IAO_0000115 "A pale yellow discoloration of the entire optic disc." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T09:02:25Z" ; oboInOwl:hasDbXref "UMLS:C4022870" ; oboInOwl:id "HP:0012512" ; a owl:Class ; rdfs:comment "Temporal pallor is seen in conditions that selectively affect the papillo-macular bundle. The word temporal refers to the temporal bone at the side of the head." ; rdfs:label "Diffuse optic disc pallor" ; rdfs:subClassOf obo:HP_0000543 . obo:HP_0012513 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the arm." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T09:07:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:102556003", "UMLS:C0239377" ; oboInOwl:hasExactSynonym "Upper limb pain" ; oboInOwl:id "HP:0012513" ; a owl:Class ; rdfs:label "Upper limb pain" ; rdfs:subClassOf obo:HP_0009763 . obo:HP_0012514 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T09:10:29Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:10601006", "UMLS:C0023222" ; oboInOwl:hasExactSynonym "Leg pain", "Lower limb pain" ; oboInOwl:id "HP:0012514" ; a owl:Class ; rdfs:label "Lower limb pain" ; rdfs:subClassOf obo:HP_0009763 . obo:HP_0012515 obo:IAO_0000115 "Reduced ability to flex the femur, that is, to pull the knee upward." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T09:14:34Z" ; oboInOwl:hasDbXref "UMLS:C3279725" ; oboInOwl:id "HP:0012515" ; a owl:Class ; rdfs:comment "Hip flexion is mediated by multiple muscles including the iliopsoas, the rectus femoris, the sartorius, and several muscles from the medial compartment of thigh." ; rdfs:label "Hip flexor weakness" ; rdfs:subClassOf obo:HP_0003749 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001779 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000366 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012516 obo:IAO_0000115 "An extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries." ; dcterms:creator ; oboInOwl:creation_date "2013-12-08T09:44:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253513005", "UMLS:C0344882" ; oboInOwl:id "HP:0012516" ; a owl:Class ; rdfs:comment "Tetralogy of Fallot with Pulmonary Atresia (TOF/PA) is a complex lesion with many different anatomic variants. The primary source of variability in this lesion is in the anatomy of the pulmonary arteries, with the spectrum ranging from well-formed, confluent pulmonary artery branches to completely absent native pulmonary arteries and major aorto-pulmonary collaterals (MAPCA's) providing all the pulmonary blood flow. The majority of cases fall somewhere in between these two ends of the spectrum, with the total pulmonary blood flow provided by a combination of diminutive native pulmonary arteries and multiple MAPCA." ; rdfs:label "Tetralogy of Fallot with pulmonary atresia" ; rdfs:subClassOf obo:HP_0001636 . obo:HP_0012517 obo:IAO_0000115 "An abnormally decreased amount of catalase level." ; dcterms:creator ; oboInOwl:creation_date "2013-12-09T06:49:18Z" ; oboInOwl:hasDbXref "UMLS:C4022869" ; oboInOwl:id "HP:0012517" ; a owl:Class ; rdfs:comment "Catalase catalyzes the decomposition of hydrogen peroxide to water and oxygen." ; rdfs:label "Reduced catalase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000005061 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012518 obo:IAO_0000115 "An anomaly of the circle of Willis, also known as the cerebral arterial circle." ; dcterms:creator ; oboInOwl:creation_date "2013-12-09T07:03:02Z" ; oboInOwl:hasDbXref "UMLS:C4022868" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral arterial circle" ; oboInOwl:id "HP:0012518" ; a owl:Class ; rdfs:comment "The circle of Willis is a circulatory anastomosis in the brain comprised of the anterior cerebral arteries, the anterior communicating artery, the internal carotid arteries, the posterior cerebral arteries, and the posterior communicating arteries." ; rdfs:label "Abnormal circle of Willis morphology" ; rdfs:subClassOf obo:HP_0009145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012519 obo:IAO_0000115 "A developmental anomnaly characterized by underdevelopment of the posterior communicating artery." ; dcterms:creator ; oboInOwl:creation_date "2013-12-09T07:06:12Z" ; oboInOwl:hasDbXref "UMLS:C4020720" ; oboInOwl:hasRelatedSynonym "Hypoplastic posterior communicating arteries" ; oboInOwl:id "HP:0012519" ; a owl:Class ; rdfs:comment "The posterior communicating arteries connect the internal carotid artery just proximal to its bifurcation into the anterior cerebral artery and middle cerebral artery with the posterior cerebral artery. The posterior communicating artery is part of the circle of Willis." ; rdfs:label "Hypoplastic posterior communicating artery" ; rdfs:subClassOf obo:HP_0031772 . obo:HP_0012520 obo:IAO_0000115 "Increased dimensions of the Virchow-Robin spaces (also known as perivascular spaces), which surround the walls of vessels as they course from the subarachnoid space through the brain parenchyma. Perivascular spaces are commonly microscopic, and not visible on conventional neuroimaging. This term refers to an increase of size of these spaces such that they are visible on neuroimaging (usually magnetic resonance imaging). The dilatations are regular cavities that always contain a patent artery." ; dcterms:creator ; oboInOwl:creation_date "2013-12-09T07:17:47Z" ; oboInOwl:hasDbXref "UMLS:C1853618", "UMLS:C4020719" ; oboInOwl:hasExactSynonym "Dilated Virchow-Robin spaces", "Perivascular spaces" ; oboInOwl:hasRelatedSynonym "Dilated cerebral perivascular spaces" ; oboInOwl:id "HP:0012520" ; a owl:Class ; rdfs:comment "Virchow-Robin spaces are commonly seen at magnetic resonance imaging. These perivascular spaces as fluid-filled spaces that follow the typical course of a vessel as it goes through grey or white matter. The spaces have signal intensity similar to that of cerebrospinal fluid (CSF) on all magnetic resonance sequences." ; rdfs:label "Dilation of Virchow-Robin spaces" ; rdfs:subClassOf obo:HP_0100659 . obo:HP_0012521 obo:IAO_0000115 "Congenital absence of the optic nerve." ; dcterms:creator ; oboInOwl:creation_date "2013-12-12T02:15:31Z" ; oboInOwl:hasDbXref "UMLS:C4021084" ; oboInOwl:hasExactSynonym "Absent optic nerve", "Aplastic optic nerve" ; oboInOwl:id "HP:0012521" ; a owl:Class ; rdfs:label "Optic nerve aplasia" ; rdfs:subClassOf obo:HP_0008058 . obo:HP_0012522 obo:IAO_0000115 "A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released." ; dcterms:creator ; oboInOwl:creation_date "2013-12-14T08:31:15Z" ; oboInOwl:hasDbXref "UMLS:C4022867" ; oboInOwl:id "HP:0012522" ; a owl:Class ; rdfs:comment "Spider hemangiomas are up to a few centimeters in diameter." ; rdfs:label "Spider hemangioma" ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0012523 obo:IAO_0000115 "Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing)." ; dcterms:creator ; oboInOwl:creation_date "2013-12-14T09:18:51Z" ; oboInOwl:hasDbXref "UMLS:C3665983" ; oboInOwl:id "HP:0012523" ; a owl:Class ; rdfs:label "Oral aversion" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0012524 obo:IAO_0000115 "A deviation from the normal discoid platelet shape." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T08:55:03Z" ; oboInOwl:hasDbXref "UMLS:C4022866" ; oboInOwl:id "HP:0012524" ; a owl:Class ; rdfs:label "Abnormal platelet shape" ; rdfs:subClassOf obo:HP_0011875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000233 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012525 obo:IAO_0000115 "An anomalous location and arrangement of platelet alpha granules." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T08:56:17Z" ; oboInOwl:hasDbXref "UMLS:C4022865" ; oboInOwl:id "HP:0012525" ; a owl:Class ; rdfs:label "Abnormal alpha granule distribution" ; rdfs:subClassOf obo:HP_0012483 . obo:HP_0012526 obo:IAO_0000115 "A lack of platelet alpha granules. This typically results in the grey appearance of platelets in giemsa stained blood smears." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T08:57:46Z" ; oboInOwl:hasDbXref "UMLS:C4022864" ; oboInOwl:hasExactSynonym "Gray platelets", "Grey platelets" ; oboInOwl:id "HP:0012526" ; a owl:Class ; rdfs:label "Absence of alpha granules" ; rdfs:subClassOf obo:HP_0012528 . obo:HP_0012527 obo:IAO_0000115 "A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:02:48Z" ; oboInOwl:hasDbXref "UMLS:C4022863" ; oboInOwl:id "HP:0012527" ; a owl:Class ; rdfs:comment "The alpha granules contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor." ; rdfs:label "Abnormal alpha granule content" ; rdfs:subClassOf obo:HP_0012483 . obo:HP_0012528 obo:IAO_0000115 "A deviation from the normal count of alpha granules per thrombocyte." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4022862" ; oboInOwl:id "HP:0012528" ; a owl:Class ; rdfs:label "Abnormal number of alpha granules" ; rdfs:subClassOf obo:HP_0012483 . obo:HP_0012529 obo:IAO_0000115 "A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:12:44Z" ; oboInOwl:hasDbXref "UMLS:C4021839" ; oboInOwl:id "HP:0012529" ; a owl:Class ; rdfs:label "Abnormal dense granule content" ; rdfs:subClassOf obo:HP_0012484 . obo:HP_0012530 obo:IAO_0000115 "A deviation from the normal count of dense granules per thrombocyte." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:12:55Z" ; oboInOwl:hasDbXref "UMLS:C4022861" ; oboInOwl:id "HP:0012530" ; a owl:Class ; rdfs:label "Abnormal number of dense granules" ; rdfs:subClassOf obo:HP_0012484 . obo:HP_0012531 obo:IAO_0000115 "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:38:08Z" ; oboInOwl:hasDbXref "MSH:D010146", "SNOMEDCT_US:22253000", "UMLS:C0030193" ; oboInOwl:hasExactSynonym "Pain" ; oboInOwl:id "HP:0012531" ; a owl:Class ; rdfs:label "Pain" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0012532 obo:IAO_0000115 "Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:46:55Z" ; oboInOwl:hasDbXref "MSH:D059350", "SNOMEDCT_US:82423001", "UMLS:C0150055" ; oboInOwl:hasExactSynonym "Chronic pain", "Long-lasting pain" ; oboInOwl:id "HP:0012532" ; a owl:Class ; rdfs:comment "Acute pain is provoked by a specific disease or injury, serves a useful biologic purpose, is associated with skeletal muscle spasm and sympathetic nervous system activation, and is self-limited. Chronic pain, in contrast, may be considered a disease state. It is pain that outlasts the normal time of healing." ; rdfs:label "Chronic pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0012533 obo:IAO_0000115 "Pain due to a stimulus that does not normally provoke pain." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:47:40Z" ; oboInOwl:hasDbXref "MSH:D006930", "SNOMEDCT_US:247404004", "UMLS:C0458247" ; oboInOwl:id "HP:0012533" ; a owl:Class ; rdfs:label "Allodynia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0012534 obo:IAO_0000115 "Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T09:59:55Z" ; oboInOwl:hasAlternativeId "HP:0031005" ; oboInOwl:hasDbXref "MSH:D010292", "SNOMEDCT_US:279079003", "UMLS:C0392699" ; oboInOwl:hasExactSynonym "Dysaesthesia", "Hyperalgesia", "Hyperpathia" ; oboInOwl:hasRelatedSynonym "Dysesthesias" ; oboInOwl:id "HP:0012534" ; a owl:Class ; rdfs:label "Dysesthesia" ; rdfs:subClassOf obo:HP_0010832 . obo:HP_0012535 obo:IAO_0000115 "An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:12:31Z" ; oboInOwl:hasDbXref "UMLS:C4021083" ; oboInOwl:hasExactSynonym "Abnormality of neurotransmitter metabolism" ; oboInOwl:id "HP:0012535" ; a owl:Class ; rdfs:label "Abnormal synaptic transmission" ; rdfs:subClassOf obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0007268 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012536 obo:IAO_0000115 "The presence of circulating autoantibodies to anticardiolipin in the mother." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:20:51Z" ; oboInOwl:hasDbXref "UMLS:C4022860" ; oboInOwl:id "HP:0012536" ; a owl:Class ; rdfs:comment "There have been reports of cerebral infarction in a newborns in association with elevated maternal anticardiolipin antibodies." ; rdfs:label "Maternal anticardiolipin antibody positive" ; rdfs:subClassOf obo:HP_0011437 . obo:HP_0012537 obo:IAO_0000115 "A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:25:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:235719002", "UMLS:C0149696" ; oboInOwl:hasExactSynonym "Food intolerance", "Non-allergic food hypersensitivity" ; oboInOwl:id "HP:0012537" ; a owl:Class ; rdfs:label "Food intolerance" ; rdfs:subClassOf obo:HP_0012337 . obo:HP_0012538 obo:IAO_0000115 "A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:31:34Z" ; oboInOwl:hasDbXref "MSH:D002446", "SNOMEDCT_US:396331005", "SNOMEDCT_US:441831003", "UMLS:C0007570", "UMLS:C0850024" ; oboInOwl:hasExactSynonym "Gluten intolerance", "Gluten sensitivity" ; oboInOwl:id "HP:0012538" ; a owl:Class ; rdfs:label "Gluten intolerance" ; rdfs:subClassOf obo:HP_0001984 . obo:HP_0012539 obo:IAO_0000115 "A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:45:49Z" ; oboInOwl:hasDbXref "MSH:D008228", "SNOMEDCT_US:118601006", "SNOMEDCT_US:128929007", "SNOMEDCT_US:188675007", "SNOMEDCT_US:1929004", "UMLS:C0024305" ; oboInOwl:id "HP:0012539" ; a owl:Class ; rdfs:label "Non-Hodgkin lymphoma" ; rdfs:subClassOf obo:HP_0002665 . obo:HP_0012540 obo:IAO_0000115 "An epidermoid cyst in the armpit." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:35:39Z" ; oboInOwl:hasDbXref "UMLS:C4022859" ; oboInOwl:hasExactSynonym "Armpit cyst" ; oboInOwl:id "HP:0012540" ; a owl:Class ; rdfs:label "Axillary epidermoid cyst" ; rdfs:subClassOf obo:HP_0200040 . obo:HP_0012541 obo:IAO_0000115 "Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:37:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:206200000", "SNOMEDCT_US:83095000", "UMLS:C0007722" ; oboInOwl:hasExactSynonym "Cephalohaematoma" ; oboInOwl:id "HP:0012541" ; a owl:Class ; rdfs:comment "Cephalohematoma is generally caused by trauma during labor." ; rdfs:label "Cephalohematoma" ; rdfs:subClassOf obo:HP_0001787, obo:HP_0001892 . obo:HP_0012542 obo:IAO_0000115 "Thickened nails without deformity." ; dcterms:creator ; oboInOwl:creation_date "2013-12-15T10:49:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:30654002", "UMLS:C0263536" ; oboInOwl:id "HP:0012542" ; a owl:Class ; rdfs:label "Onychauxis" ; rdfs:subClassOf obo:HP_0001805 . obo:HP_0012543 obo:IAO_0000115 "The presence of hemosiderin in the urine." ; dcterms:creator ; oboInOwl:creation_date "2013-12-21T09:09:38Z" ; oboInOwl:hasDbXref "UMLS:C2721579" ; oboInOwl:id "HP:0012543" ; a owl:Class ; rdfs:comment "Hemosiderinuria leads to a brown color of urine. It is a marker of chronic intravascular hemolysis, in which hemoglobin is released from RBCs into the bloodstream in excess of the binding capacity of haptoglobin." ; rdfs:label "Hemosiderinuria" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0012544 obo:IAO_0000115 "Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2013-12-21T09:18:43Z" ; oboInOwl:hasDbXref "UMLS:C4022858" ; oboInOwl:hasExactSynonym "Elevated aldolase level" ; oboInOwl:id "HP:0012544" ; a owl:Class ; rdfs:comment "Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate." ; rdfs:label "Elevated circulating aldolase concentration" ; rdfs:subClassOf obo:HP_0012400 . obo:HP_0012545 obo:IAO_0000115 "Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2013-12-21T09:20:49Z" ; oboInOwl:hasDbXref "UMLS:C4022857" ; oboInOwl:hasExactSynonym "Reduced aldolase level" ; oboInOwl:id "HP:0012545" ; a owl:Class ; rdfs:comment "Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate." ; rdfs:label "Reduced circulating aldolase concentration" ; rdfs:subClassOf obo:HP_0012400 . obo:HP_0012546 obo:IAO_0000115 "A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells." ; dcterms:creator ; oboInOwl:creation_date "2013-12-21T09:22:57Z" ; oboInOwl:hasDbXref "UMLS:C4022856" ; oboInOwl:id "HP:0012546" ; a owl:Class ; rdfs:comment "X chromosome inactivation (XCI) is the process by which one of the two copies of the X chromosome present in females is inactivated in order to achieves dosage equivalency for X-linked genes between XY males and XX females. An individual cell's decision to inactivate either the paternal or maternal X is made early in development, at approximately the time of implantation, such that normally there is a roughly equal distribution of either X being active. A deviation from equality is known as skewing, with common criteria for \"skewed\" inactivation being arbitrarily defined as the observation of inactivation of the same allele in 75% or 80% of cells (and very skewed inactivation resulting in 90% or 95% of cells with the same allele inactive). For some X-linked diseases there is strong selection in the heterozygous carrier in favor of cells bearing the mutation on the silenced inactive X, and thus, assessment of XCI skewing in female family members can be suggestive of carrier status." ; rdfs:label "Skewed maternal X inactivation" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0012547 obo:IAO_0000115 "Anomalous movements of the eyes that occur without the subject wanting them to happen." ; dcterms:creator ; oboInOwl:creation_date "2013-12-21T10:37:42Z" ; oboInOwl:hasDbXref "UMLS:C4022855" ; oboInOwl:id "HP:0012547" ; a owl:Class ; rdfs:label "Abnormal involuntary eye movements" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0012548 obo:IAO_0000115 "Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers" ; dcterms:creator ; oboInOwl:creation_date "2014-01-01T03:03:05Z" ; oboInOwl:hasDbXref "UMLS:C4021082" ; oboInOwl:hasExactSynonym "Skeletal muscle fatty infiltration" ; oboInOwl:id "HP:0012548" ; a owl:Class ; rdfs:comment "Fatty infiltration of muscle tissue can be observed on muscle biopsy as well as through imaging by computed tomography and magnetic resonance tomography." ; rdfs:label "Fatty replacement of skeletal muscle" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0012549 obo:IAO_0000115 "A lipoma (a benign tumor composed of adipose tissue) located in the conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2014-01-01T03:13:56Z" ; oboInOwl:hasDbXref "NCIT:C3192", "UMLS:C4022854" ; oboInOwl:id "HP:0012549" ; a owl:Class ; rdfs:comment "Conjunctival lipoma displays yellowish-pink stromal mass, histologically with large lipid vacuoles surrounded by stellate cells." ; rdfs:label "Conjunctival lipoma" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0012550 obo:IAO_0000115 "The presence of varices (enlarged and convoluted blood vessels) in the colon." ; dcterms:creator ; oboInOwl:creation_date "2014-01-01T03:54:41Z" ; oboInOwl:hasDbXref "UMLS:C4022853" ; oboInOwl:id "HP:0012550" ; a owl:Class ; rdfs:comment "Colonic varices are a rare cause of lower gastrointestinal bleeding, most commonly associated with portal hypertension nd more rarely with congestive heart failure, mesenteric vein thrombosis, pancreatitis with splenic vein thrombosis and adhesions, and mesenteric vein compression. Colonic varices are usually located in the rectosigmoid region and the cecum." ; rdfs:label "Colonic varices" ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0012551 obo:IAO_0000115 "Lack of specific granules in neutrophils." ; dcterms:creator ; oboInOwl:creation_date "2014-01-01T03:32:09Z" ; oboInOwl:hasDbXref "UMLS:C4022852" ; oboInOwl:id "HP:0012551" ; a owl:Class ; rdfs:comment "Neutrophil polymorphonuclear leukocytes (PMNs) contain two principal types of granules. Azurophil granules appear early in neutrophil development and contain lysosomal enzymes, lysozyme, and myeloperoxidase (MPO). Specific granules are formed later, lack MPO and hydrolases, but contain lactoferrin and the remainder of the cell's complement of lysozyme. Consequently, specific granules may be conveniently detected at the electron-microscopic (EM) level by the cytochemical demonstration of their lack of MPO, while at the optical level their presence can be inferred from their positive immunocytochemical staining for lactoferrin with the use of specific antiserums." ; rdfs:label "Absent neutrophil specific granules" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0012552 obo:IAO_0000115 "Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs." ; dcterms:creator ; oboInOwl:creation_date "2014-01-01T03:41:24Z" ; oboInOwl:hasDbXref "UMLS:C4022851" ; oboInOwl:id "HP:0012552" ; a owl:Class ; rdfs:label "Increased neutrophil nuclear projections" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0012553 obo:IAO_0000115 "A thumbnail that is diminished in length and width, i.e., underdeveloped thumb nail." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T12:57:28Z" ; oboInOwl:hasDbXref "UMLS:C4022850" ; oboInOwl:hasExactSynonym "Small thumbnail", "Underdeveloped thumbnail" ; oboInOwl:id "HP:0012553" ; a owl:Class ; rdfs:label "Hypoplastic thumbnail" ; rdfs:subClassOf obo:HP_0001804 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012554 obo:IAO_0000115 "Absence of thumb nail." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:05:52Z" ; oboInOwl:hasDbXref "UMLS:C4022849" ; oboInOwl:id "HP:0012554" ; a owl:Class ; rdfs:label "Absent thumbnail" ; rdfs:subClassOf obo:HP_0001817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012555 obo:IAO_0000115 "Absent nail of big toe." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:06:39Z" ; oboInOwl:hasDbXref "UMLS:C4021081" ; oboInOwl:hasExactSynonym "Absent big toe nail", "Absent nail of big toe" ; oboInOwl:id "HP:0012555" ; a owl:Class ; rdfs:label "Absent nail of hallux" ; rdfs:subClassOf obo:HP_0001802 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011278 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012556 obo:IAO_0000115 "Increased concentration of beta-alanine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:37:23Z" ; oboInOwl:hasDbXref "UMLS:C4021080" ; oboInOwl:hasExactSynonym "High blood beta-alanine levels", "Hyperbetaalaninemia" ; oboInOwl:id "HP:0012556" ; a owl:Class ; rdfs:label "Hyperbeta-alaninemia" ; rdfs:subClassOf obo:HP_0033109 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012557 obo:IAO_0000115 "EEG with focal sharp transient waves in the centrotemporal region of the brain (also known as the central sulcus), i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:43:32Z" ; oboInOwl:hasDbXref "UMLS:C4022848" ; oboInOwl:id "HP:0012557" ; a owl:Class ; rdfs:label "EEG with centrotemporal focal spike waves" ; rdfs:subClassOf obo:HP_0011197, obo:HP_0033721 . obo:HP_0012558 obo:IAO_0000115 "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:50:30Z" ; oboInOwl:hasDbXref "UMLS:C4022847" ; oboInOwl:id "HP:0012558" ; a owl:Class ; rdfs:label "Abnormal T3/T4 ratio" ; rdfs:subClassOf obo:HP_0031508 . obo:HP_0012559 obo:IAO_0000115 "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is higher than normal." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:52:59Z" ; oboInOwl:hasDbXref "UMLS:C4022846" ; oboInOwl:id "HP:0012559" ; a owl:Class ; rdfs:label "Increased T3/T4 ratio" ; rdfs:subClassOf obo:HP_0012558 . obo:HP_0012560 obo:IAO_0000115 "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is lower than normal." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T01:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022845" ; oboInOwl:id "HP:0012560" ; a owl:Class ; rdfs:label "Decreased T3/T4 ratio" ; rdfs:subClassOf obo:HP_0012558 . obo:HP_0012561 obo:IAO_0000115 "The presence of an aortic valve with one instead of the normal three cusps (flaps)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-08T08:14:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253610004", "UMLS:C0345001" ; oboInOwl:id "HP:0012561" ; a owl:Class ; rdfs:comment "The aortic valve normally has three cusps (flaps), that is, it is normally tricuspid. Unicuspid aortic valve (UAV) shares many of the features of bicuspid aortic valve, including valvular dysfunction, aortic dilatation, aortic dissection, and dystrophic calcification, although these conditions develop at an earlier age and progress at a faster pace in UAV." ; rdfs:label "Unicuspid aortic valve" ; rdfs:subClassOf obo:HP_0031567 . obo:HP_0012562 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the hand, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:02:35Z" ; oboInOwl:hasDbXref "UMLS:C4022844" ; oboInOwl:id "HP:0012562" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in hand" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012563 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the foot, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:05:25Z" ; oboInOwl:hasDbXref "UMLS:C4022843" ; oboInOwl:id "HP:0012563" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in foot" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012564 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the tibia, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:07:34Z" ; oboInOwl:hasDbXref "UMLS:C4022842" ; oboInOwl:id "HP:0012564" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in tibia" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012565 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the fibula, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:08:23Z" ; oboInOwl:hasDbXref "UMLS:C4021838" ; oboInOwl:id "HP:0012565" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in fibula" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012566 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the radius, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:09:50Z" ; oboInOwl:hasDbXref "UMLS:C4022841" ; oboInOwl:id "HP:0012566" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in radius" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012567 obo:IAO_0000115 "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the ulna, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:10:05Z" ; oboInOwl:hasDbXref "UMLS:C4022840" ; oboInOwl:id "HP:0012567" ; a owl:Class ; rdfs:label "Premature epimetaphyseal fusion in ulna" ; rdfs:subClassOf obo:HP_0010588 . obo:HP_0012568 obo:IAO_0000115 "Edema in the region of the Lower eyelid." ; dcterms:creator ; oboInOwl:creation_date "2014-01-04T02:25:56Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:700327003", "UMLS:C2025810", "UMLS:C3839997" ; oboInOwl:hasExactSynonym "Cellulitis of lower eyelid", "Fullness of lower eyelid", "Lower eyelid oedema", "Puffiness of lower eyelid", "Swelling of lower eyelid" ; oboInOwl:id "HP:0012568" ; a owl:Class ; rdfs:label "Lower eyelid edema" ; rdfs:subClassOf obo:HP_0100540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012569 obo:IAO_0000115 "First period after the age of 15 years." ; dcterms:creator ; oboInOwl:creation_date "2014-01-08T08:20:18Z" ; oboInOwl:hasDbXref "UMLS:C0949173" ; oboInOwl:hasExactSynonym "Delayed start of first period" ; oboInOwl:id "HP:0012569" ; a owl:Class ; rdfs:label "Delayed menarche" ; rdfs:subClassOf obo:HP_0000140, obo:HP_0000823 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042696 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012570 obo:IAO_0000115 "A type of mesenchymal tissue cell tumor that exhibits epithelial differentiation, which most frequently arises in the extremities." ; dcterms:creator ; oboInOwl:creation_date "2014-01-08T08:47:50Z" ; oboInOwl:hasDbXref "MSH:D013584", "SNOMEDCT_US:302851001", "SNOMEDCT_US:63211008", "UMLS:C0039101" ; oboInOwl:hasExactSynonym "Malignant synovioma" ; oboInOwl:id "HP:0012570" ; a owl:Class ; rdfs:comment "Synovial sarcoma is a high-grade tumor that is associated with poor prognosis." ; rdfs:label "Synovial sarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0012571 obo:IAO_0000115 "A partial duplication of the ureter where the duplicated ureters fuse to a single ureter before their insertion into the bladder." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T11:38:41Z" ; oboInOwl:hasDbXref "ICD-10:Q62.5", "UMLS:C4021079" ; oboInOwl:hasExactSynonym "Partially duplicated ureter" ; oboInOwl:id "HP:0012571" ; a owl:Class ; rdfs:comment "This anomaly is only seen in the presence of renal duplication." ; rdfs:label "Ureter fissus" ; rdfs:subClassOf obo:HP_0000073 . obo:HP_0012572 obo:IAO_0000115 "A complete duplication of the ureter, where the duplicated ureters have separate insertions into the bladder." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T11:42:00Z" ; oboInOwl:hasDbXref "ICD-10:Q62.5", "SNOMEDCT_US:49496001", "UMLS:C0221365" ; oboInOwl:id "HP:0012572" ; a owl:Class ; rdfs:label "Ureter duplex" ; rdfs:subClassOf obo:HP_0000073 . obo:HP_0012573 obo:IAO_0000115 "A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T12:27:40Z" ; oboInOwl:hasDbXref "UMLS:C4022839" ; oboInOwl:id "HP:0012573" ; a owl:Class ; rdfs:label "Global proximal tubulopathy" ; rdfs:subClassOf obo:HP_0000114 . obo:HP_0012574 obo:IAO_0000115 "Increased numbers of mesangial cells per glomerulus, defined as more than 3 nuclei fully surrounded by matrix in one or more mesangial areas, not including perihilar region, on a standard 3-micron-thick tissue section, best evaluated on periodic acid-Schiff (PAS) stain." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T12:43:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:125510009", "UMLS:C0545017" ; oboInOwl:hasExactSynonym "Mesangial proliferation" ; oboInOwl:id "HP:0012574" ; a owl:Class ; rdfs:comment "See Figure 3a of PMID:32866505." ; rdfs:label "Mesangial hypercellularity" ; rdfs:subClassOf obo:HP_0033231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0008283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012575 obo:IAO_0000115 "A structural anomaly of the nephron." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T12:49:04Z" ; oboInOwl:hasDbXref "UMLS:C4022838" ; oboInOwl:hasExactSynonym "Abnormality of the nephron" ; oboInOwl:id "HP:0012575" ; a owl:Class ; rdfs:label "Abnormal nephron morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001285 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012576 obo:IAO_0000115 "The presence of complement 3 deposits in the glomerulus." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T01:08:21Z" ; oboInOwl:hasDbXref "UMLS:C4022837" ; oboInOwl:hasExactSynonym "Renal C3 deposition" ; oboInOwl:hasRelatedSynonym "C3 nephropathy" ; oboInOwl:id "HP:0012576" ; a owl:Class ; rdfs:label "Glomerular C3 deposition" ; rdfs:subClassOf obo:HP_0030949 . obo:HP_0012577 obo:IAO_0000115 "Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T01:21:17Z" ; oboInOwl:hasDbXref "UMLS:C3276821" ; oboInOwl:id "HP:0012577" ; a owl:Class ; rdfs:comment "This finding is demonstrated on renal biopsy." ; rdfs:label "Thin glomerular basement membrane" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0012578 obo:IAO_0000115 "A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T01:22:41Z" ; oboInOwl:hasDbXref "MSH:D015433", "SNOMEDCT_US:77182004", "UMLS:C0017665" ; oboInOwl:hasExactSynonym "Membranous glomerulonephritis" ; oboInOwl:id "HP:0012578" ; a owl:Class ; rdfs:label "Membranous nephropathy" ; rdfs:subClassOf obo:HP_0000099 . obo:HP_0012579 obo:IAO_0000115 "The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T01:26:20Z" ; oboInOwl:hasDbXref "MSH:D009402", "SNOMEDCT_US:44785005", "UMLS:C0027721" ; oboInOwl:hasExactSynonym "Minimal change disease", "Minimal change nephropathy" ; oboInOwl:id "HP:0012579" ; a owl:Class ; rdfs:label "Minimal change glomerulonephritis" ; rdfs:subClassOf obo:HP_0000099 . obo:HP_0012580 obo:IAO_0000115 "The presence of calcium- and phosphate-containing calculi (stones) in the kidneys." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T01:34:27Z" ; oboInOwl:hasDbXref "UMLS:C3671880" ; oboInOwl:hasExactSynonym "Ca phosphate nephrolithiasis", "Ca phosphate urolithiasis", "Ca2+ phosphate nephrolitiasis", "Ca2+ phosphate urolithiasis" ; oboInOwl:hasRelatedSynonym "Calcium phosphate urolithiasis" ; oboInOwl:id "HP:0012580" ; a owl:Class ; rdfs:label "Calcium phosphate nephrolithiasis" ; rdfs:subClassOf obo:HP_0004724 . obo:HP_0012581 obo:IAO_0000115 "An isolated cyst of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:06:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77945009", "UMLS:C0268800", "UMLS:C4022836" ; oboInOwl:hasExactSynonym "Simple kidney cyst", "Solitary renal cyst", "single cortical cyst" ; oboInOwl:id "HP:0012581" ; a owl:Class ; rdfs:label "Simple renal cyst" ; rdfs:subClassOf obo:HP_0000107 . obo:HP_0012582 obo:IAO_0000115 "A bilateral form of developmental dysplasia of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:14:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204950001", "UMLS:C0431698" ; oboInOwl:id "HP:0012582" ; a owl:Class ; rdfs:label "Bilateral renal dysplasia" ; rdfs:subClassOf obo:HP_0000110 . obo:HP_0012583 obo:IAO_0000115 "One sided hypoplasia of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:15:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204948009", "UMLS:C0431691" ; oboInOwl:hasExactSynonym "Small kidney on one side", "Underdeveloped kidney on one side" ; oboInOwl:id "HP:0012583" ; a owl:Class ; rdfs:label "Unilateral renal hypoplasia" ; rdfs:subClassOf obo:HP_0000089 . obo:HP_0012584 obo:IAO_0000115 "Two sided hypoplasia of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:16:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:268232000", "UMLS:C0431692" ; oboInOwl:id "HP:0012584" ; a owl:Class ; rdfs:label "Bilateral renal hypoplasia" ; rdfs:subClassOf obo:HP_0000089 . obo:HP_0012585 obo:IAO_0000115 "Atrophy of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:21:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:197659005", "UMLS:C0341698" ; oboInOwl:hasExactSynonym "Kidney degeneration" ; oboInOwl:id "HP:0012585" ; a owl:Class ; rdfs:label "Renal atrophy" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012586 obo:IAO_0000115 "A two-sided form of atrophy of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:21:55Z" ; oboInOwl:hasDbXref "UMLS:C4022835" ; oboInOwl:hasExactSynonym "Bilateral kidney degeneration" ; oboInOwl:id "HP:0012586" ; a owl:Class ; rdfs:label "Bilateral renal atrophy" ; rdfs:subClassOf obo:HP_0012585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0012587 obo:IAO_0000115 "Hematuria that is visible upon inspection of the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:31:44Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:197941005", "UMLS:C0473237" ; oboInOwl:hasExactSynonym "Bloody urine", "Gross hematuria" ; oboInOwl:id "HP:0012587" ; a owl:Class ; rdfs:label "Macroscopic hematuria" ; rdfs:subClassOf obo:HP_0000790 . obo:HP_0012588 obo:IAO_0000115 "A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:47:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:236381000", "UMLS:C0403397" ; oboInOwl:hasExactSynonym "SRNS" ; oboInOwl:id "HP:0012588" ; a owl:Class ; rdfs:comment "Genetic studies and biopsy are necessary. Treatment depends on result. Genetic forms are treated symptomatically with ACE-inhibitor or angiotensin receptor blockers. Non-genetic forms are usually treated with calcineurin inhibitors. Prognosis is worse than in SSNS. 50 % progress into end-stage renal disease." ; rdfs:label "Steroid-resistant nephrotic syndrome" ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0012589 obo:IAO_0000115 "A form of nephrotic syndrome that does not respond to any immunosuppresive treatment." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:48:49Z" ; oboInOwl:hasDbXref "UMLS:C4022834" ; oboInOwl:id "HP:0012589" ; a owl:Class ; rdfs:label "Multidrug-resistant nephrotic syndrome" ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0012590 obo:IAO_0000115 "An abnormal amount of urine production." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T03:59:33Z" ; oboInOwl:hasDbXref "UMLS:C3693260" ; oboInOwl:id "HP:0012590" ; a owl:Class ; rdfs:label "Abnormal urine output" ; rdfs:subClassOf obo:HP_0011036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012591 obo:IAO_0000115 "An abnormality in the concentration of electrolytes in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:44:11Z" ; oboInOwl:hasDbXref "UMLS:C4022833" ; oboInOwl:hasExactSynonym "Urinary electrolyte imbalance" ; oboInOwl:id "HP:0012591" ; a owl:Class ; rdfs:label "Abnormal urinary electrolyte concentration" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0012592 obo:IAO_0000115 "Increased concentration of albumin in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:49:16Z" ; oboInOwl:hasDbXref "MSH:D000419", "SNOMEDCT_US:274769005", "UMLS:C0001925" ; oboInOwl:id "HP:0012592" ; a owl:Class ; rdfs:label "Albuminuria" ; rdfs:subClassOf obo:HP_0020129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012593 obo:IAO_0000115 "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:50:21Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:264867001", "UMLS:C0445118" ; oboInOwl:id "HP:0012593" ; a owl:Class ; rdfs:label "Nephrotic range proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_0012594 obo:IAO_0000115 "The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:54:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:312975006", "UMLS:C0730345", "UMLS:C1654921" ; oboInOwl:hasExactSynonym "High urine albumin levels", "Microalbuminuria" ; oboInOwl:id "HP:0012594" ; a owl:Class ; rdfs:label "Moderate albuminuria" ; rdfs:subClassOf obo:HP_0012592 . obo:HP_0012595 obo:IAO_0000115 "Mildly increased levels of protein in the urine (150-500 mg per day in adults)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:55:47Z" ; oboInOwl:hasDbXref "UMLS:C4022832" ; oboInOwl:id "HP:0012595" ; a owl:Class ; rdfs:label "Mild proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_0012596 obo:IAO_0000115 "Moderately increased levels of protein in the urine (500-1000 mg per day in adults)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:56:26Z" ; oboInOwl:hasDbXref "UMLS:C4022831" ; oboInOwl:id "HP:0012596" ; a owl:Class ; rdfs:label "Moderate proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_0012597 obo:IAO_0000115 "Severely increased levels of protein in the urine (1000-3000 mg per day in adults)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T05:56:38Z" ; oboInOwl:hasDbXref "UMLS:C4022830" ; oboInOwl:hasExactSynonym "Severly high blood protein levels" ; oboInOwl:id "HP:0012597" ; a owl:Class ; rdfs:label "Heavy proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_0012598 obo:IAO_0000115 "An abnormal concentration of potassium(1+) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:11:59Z" ; oboInOwl:hasDbXref "UMLS:C4022829" ; oboInOwl:hasExactSynonym "Abnormal urine K concentration" ; oboInOwl:id "HP:0012598" ; a owl:Class ; rdfs:label "Abnormal urine potassium concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012599 obo:IAO_0000115 "An abnormal phosphate concentration in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:14:49Z" ; oboInOwl:hasDbXref "UMLS:C4022828" ; oboInOwl:id "HP:0012599" ; a owl:Class ; rdfs:label "Abnormal urine phosphate concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012600 obo:IAO_0000115 "An abnormal concentration of chloride in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:16:24Z" ; oboInOwl:hasDbXref "UMLS:C4022827" ; oboInOwl:hasExactSynonym "Abnormal urine Cl concentration", "Abnormal urine Cl- concentration" ; oboInOwl:id "HP:0012600" ; a owl:Class ; rdfs:label "Abnormal urine chloride concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012601 obo:IAO_0000115 "An decreased concentration of chloride in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:17:06Z" ; oboInOwl:hasDbXref "UMLS:C4021078" ; oboInOwl:hasExactSynonym "Decreased urinary chloride", "Low urine chloride levels" ; oboInOwl:id "HP:0012601" ; a owl:Class ; rdfs:label "Hypochloriduria" ; rdfs:subClassOf obo:HP_0012600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012602 obo:IAO_0000115 "High urine chloride in the presence of hypochloridemia." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:18:11Z" ; oboInOwl:hasDbXref "UMLS:C4022826" ; oboInOwl:hasExactSynonym "Kidney chloride wasting", "Renal Cl wasting", "Renal Cl- wasting" ; oboInOwl:id "HP:0012602" ; a owl:Class ; rdfs:label "Renal chloride wasting" ; rdfs:subClassOf obo:HP_0012600 . obo:HP_0012603 obo:IAO_0000115 "An abnormal concentration of sodium in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:19:27Z" ; oboInOwl:hasDbXref "UMLS:C4022825" ; oboInOwl:hasExactSynonym "Abnormal urine Na concentration", "Abnormal urine Na+ levels" ; oboInOwl:id "HP:0012603" ; a owl:Class ; rdfs:label "Abnormal urine sodium concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012604 obo:IAO_0000115 "An abnormally decreased sodium concentration in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:22:09Z" ; oboInOwl:hasDbXref "UMLS:C4022824" ; oboInOwl:hasExactSynonym "Low urine sodium levels" ; oboInOwl:id "HP:0012604" ; a owl:Class ; rdfs:label "Hyponatriuria" ; rdfs:subClassOf obo:HP_0012603 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012605 obo:IAO_0000115 "An increased concentration of sodium(1+) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:22:44Z" ; oboInOwl:hasAlternativeId "HP:0003608" ; oboInOwl:hasDbXref "UMLS:C3671887" ; oboInOwl:hasExactSynonym "Increased urinary sodium" ; oboInOwl:id "HP:0012605" ; a owl:Class ; rdfs:label "Hypernatriuria" ; rdfs:subClassOf obo:HP_0012603 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012606 obo:IAO_0000115 "An abnormally increased sodium concentration in the urine in the presence of hyponatremia." ; dcterms:creator ; oboInOwl:creation_date "2014-01-16T06:23:16Z" ; oboInOwl:hasDbXref "UMLS:C2748576" ; oboInOwl:hasExactSynonym "Kidney sodium wasting", "Renal Na wasting", "Renal Na+ wasting" ; oboInOwl:id "HP:0012606" ; a owl:Class ; rdfs:label "Renal sodium wasting" ; rdfs:subClassOf obo:HP_0012603 . obo:HP_0012607 obo:IAO_0000115 "An abnormal concentration of magnesium the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:37:50Z" ; oboInOwl:hasDbXref "UMLS:C4022823" ; oboInOwl:hasExactSynonym "Abnormal urine magnesium concentration" ; oboInOwl:id "HP:0012607" ; a owl:Class ; rdfs:label "Abnormal urine magnesium concentration" ; rdfs:subClassOf obo:HP_0012591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25107 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012608 obo:IAO_0000115 "An increased concentration of magnesium the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:38:51Z" ; oboInOwl:hasDbXref "UMLS:C2673443" ; oboInOwl:id "HP:0012608" ; a owl:Class ; rdfs:label "Hypermagnesiuria" ; rdfs:subClassOf obo:HP_0012607 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25107 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012609 obo:IAO_0000115 "An decreased concentration of magnesium the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:39:31Z" ; oboInOwl:hasDbXref "UMLS:C3203528" ; oboInOwl:hasExactSynonym "Decreased urine magnesium", "Low urine magnesium levels" ; oboInOwl:id "HP:0012609" ; a owl:Class ; rdfs:label "Hypomagnesiuria" ; rdfs:subClassOf obo:HP_0012607 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25107 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012610 obo:IAO_0000115 "Abnormal amount of urate in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:56:43Z" ; oboInOwl:hasDbXref "UMLS:C4022822" ; oboInOwl:id "HP:0012610" ; a owl:Class ; rdfs:comment "Xanthine oxidase oxidizes oxypurines such as xanthine and hypoxanthine to uric acid. Uric acid is the final oxidation product of purine catabolism." ; rdfs:label "Abnormality of urinary uric acid level" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27226 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012611 obo:IAO_0100001 "HP:0003149" ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:57:29Z" ; oboInOwl:id "HP:0012611" ; a owl:Class ; rdfs:label "obsolete Increased urinary urate" ; owl:deprecated true . obo:HP_0012612 obo:IAO_0000115 "Abnormal concentration of sulfate in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:58:23Z" ; oboInOwl:hasDbXref "UMLS:C4022821" ; oboInOwl:hasExactSynonym "Abnormal urinary sulphate concentration" ; oboInOwl:id "HP:0012612" ; a owl:Class ; rdfs:label "Abnormal urinary sulfate concentration" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16189 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012613 obo:IAO_0000115 "Elevated concentration of SO4(2-), i.e., sulfate, in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:58:51Z" ; oboInOwl:hasDbXref "UMLS:C4022820" ; oboInOwl:hasExactSynonym "Increased urinary sulphate" ; oboInOwl:id "HP:0012613" ; a owl:Class ; rdfs:label "Increased urinary sulfate" ; rdfs:subClassOf obo:HP_0012612 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16189 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012614 obo:IAO_0000115 "An anomalous finding in the examination of the urine for cells." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:01:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:310439007", "UMLS:C0587955" ; oboInOwl:id "HP:0012614" ; a owl:Class ; rdfs:label "Abnormal urine cytology" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0012615 obo:IAO_0000115 "The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:03:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:5277004", "UMLS:C0151990" ; oboInOwl:hasExactSynonym "Urinary casts" ; oboInOwl:id "HP:0012615" ; a owl:Class ; rdfs:comment "Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. The casts are suibsequently eliminated via the urine and may be seen by microscopy of the urine sediment. A large number of casts can indicate kidney disease. Urinary casts are composed of Tamm-Horsfall protein, which is a mucoprotein that is secreted by the distal loop of Henle." ; rdfs:label "Cylindruria" ; rdfs:subClassOf obo:HP_0012614 . obo:HP_0012616 obo:IAO_0000115 "Presence of leukocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:05:08Z" ; oboInOwl:hasDbXref "UMLS:C4022819" ; oboInOwl:hasExactSynonym "White blood cell casts" ; oboInOwl:id "HP:0012616" ; a owl:Class ; rdfs:label "Leukocyte cylindruria" ; rdfs:subClassOf obo:HP_0031197 . obo:HP_0012617 obo:IAO_0000115 "Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:06:50Z" ; oboInOwl:hasDbXref "UMLS:C4022818" ; oboInOwl:hasExactSynonym "Red blood cell casts", "Urinary erythrocyte cast" ; oboInOwl:id "HP:0012617" ; a owl:Class ; rdfs:label "Erythrocyte cylindruria" ; rdfs:subClassOf obo:HP_0031197 . obo:HP_0012618 obo:IAO_0000115 "A cyst located along the allantois canal." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:15:15Z" ; oboInOwl:hasDbXref "MSH:D014496", "SNOMEDCT_US:17234001", "UMLS:C0041915" ; oboInOwl:id "HP:0012618" ; a owl:Class ; rdfs:label "Urachal cyst" ; rdfs:subClassOf obo:HP_0010478 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012619 obo:IAO_0000115 "Presence of a many diverticula (sac or pouch) in the wall of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:21:05Z" ; oboInOwl:hasDbXref "UMLS:C4022817" ; oboInOwl:hasExactSynonym "Multiple pouches in bladder wall" ; oboInOwl:id "HP:0012619" ; a owl:Class ; rdfs:label "Multiple bladder diverticula" ; rdfs:subClassOf obo:HP_0000015 . obo:HP_0012620 obo:IAO_0000115 "A developmental anomaly associated with the failure of rectum, vagina, and bladder to separate." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:27:06Z" ; oboInOwl:hasDbXref "UMLS:C4022816" ; oboInOwl:id "HP:0012620" ; a owl:Class ; rdfs:label "Cloacal abnormality" ; rdfs:subClassOf obo:HP_0000119, obo:HP_0010866 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012621 obo:IAO_0000115 "Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T12:28:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:74829002", "UMLS:C0266225" ; oboInOwl:hasExactSynonym "Cloacogenic bladder" ; oboInOwl:id "HP:0012621" ; a owl:Class ; rdfs:label "Persistent cloaca" ; rdfs:subClassOf obo:HP_0012620 . obo:HP_0012622 obo:IAO_0000115 "Functional anomaly of the kidney persisting for at least three months." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T01:14:52Z" ; oboInOwl:hasAlternativeId "HP:0000106", "HP:0001918", "HP:0008671" ; oboInOwl:hasDbXref "MSH:D051436", "SNOMEDCT_US:709044004", "UMLS:C0748318", "UMLS:C1561643" ; oboInOwl:hasExactSynonym "Chronic kidney disease" ; oboInOwl:hasRelatedSynonym "Loss of renal function", "Progressive renal failure", "Progressive renal insufficiency", "Renal failure, progressive", "Renal insufficiency, progressive" ; oboInOwl:id "HP:0012622" ; a owl:Class ; rdfs:label "Chronic kidney disease" ; rdfs:subClassOf obo:HP_0000083 . obo:HP_0012623 obo:IAO_0000115 "A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T01:20:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:431855005", "UMLS:C2316401" ; oboInOwl:id "HP:0012623" ; a owl:Class ; rdfs:comment "Proteinuria is commonly seen in stage 1 chronic kidney disease." ; rdfs:label "Stage 1 chronic kidney disease" ; rdfs:subClassOf obo:HP_0012622 . obo:HP_0012624 obo:IAO_0000115 "A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T01:22:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:431856006", "UMLS:C2316786" ; oboInOwl:id "HP:0012624" ; a owl:Class ; rdfs:label "Stage 2 chronic kidney disease" ; rdfs:subClassOf obo:HP_0012622 . obo:HP_0012625 obo:IAO_0000115 "A type of chronic kidney disease with moderately reduced glomerular filtration rate (GFR 30-59 mL/min/1.73 m2)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T01:22:43Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:433144002", "UMLS:C2316787" ; oboInOwl:id "HP:0012625" ; a owl:Class ; rdfs:label "Stage 3 chronic kidney disease" ; rdfs:subClassOf obo:HP_0012622 . obo:HP_0012626 obo:IAO_0000115 "A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2)." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T01:23:43Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:431857002", "UMLS:C2317473" ; oboInOwl:hasExactSynonym "Stage 4 chronic kidney disease" ; oboInOwl:id "HP:0012626" ; a owl:Class ; rdfs:label "Stage 4 chronic kidney disease" ; rdfs:subClassOf obo:HP_0012622 . obo:HP_0012627 obo:IAO_0000115 "Deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T10:50:32Z" ; oboInOwl:hasDbXref "UMLS:C4022815" ; oboInOwl:id "HP:0012627" ; a owl:Class ; rdfs:comment "In the eye, pseudoexfoliation syndrome is characterized by the deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor. PXM can be observed in vivo during slit lamp examination. It appears as 'dandruff-like' material in the anterior chamber or most characteristically on the anterior lens capsule deposited in a double concentric ring pattern. The rings are separated by a clear zone presumably created because of the movement of the iris on the anterior lens surface. The central ring is located at the area of the iris sphincter, while the peripheral ring is only visible after pupil dilation. PXM is also often observed by slit lamp examination at the pupillary margin, on the lens zonules and on the trabecular meshwork. The site of production of this material which is a complex of various glycoproteins is unclear, but PXM can potentially originate from the iris, lens epithelium, ciliary body, or the trabecular meshwork." ; rdfs:label "Pseudoexfoliation" ; rdfs:subClassOf obo:HP_0004328 . obo:HP_0012628 obo:IAO_0000115 "An anomaly of the suspensory ligament of lens, also known as the ciliary zonule. These ligaments represent a series of fibers connecting the ciliary body and lens of the eye, holding the lens in place." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T10:59:37Z" ; oboInOwl:hasDbXref "UMLS:C4021077" ; oboInOwl:hasExactSynonym "Abnormality of the suspensory ligament of lens", "Abnormality of zinn's membrane", "Ciliary zonule abnormality", "Zonule of zinn abnormality" ; oboInOwl:id "HP:0012628" ; a owl:Class ; rdfs:label "Abnormal suspensory ligament of lens morphology" ; rdfs:subClassOf obo:HP_0004328 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006762 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012629 obo:IAO_0000115 "Tremulousness (trembling) of the lens of the eye." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:03:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:116669003", "UMLS:C2939415" ; oboInOwl:hasExactSynonym "Phacodonesis", "Trembling eye lens" ; oboInOwl:id "HP:0012629" ; a owl:Class ; rdfs:comment "Phacodonesis results from lesions of some or most of the zonular fibres are broken." ; rdfs:label "Phakodonesis" ; rdfs:subClassOf obo:HP_0000517 . obo:HP_0012630 obo:IAO_0000115 "An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:12:27Z" ; oboInOwl:hasDbXref "UMLS:C4022814" ; oboInOwl:hasExactSynonym "Abnormality of the trabecular meshwork" ; oboInOwl:id "HP:0012630" ; a owl:Class ; rdfs:label "Abnormal trabecular meshwork morphology" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0012631 obo:IAO_0000115 "Accumulation of abnormal amounts of pigment within the trabecular meshwork." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:15:03Z" ; oboInOwl:hasDbXref "UMLS:C3805899" ; oboInOwl:id "HP:0012631" ; a owl:Class ; rdfs:comment "Gonioscopy can be used to reveal pigment deposition on the trabecular meshwork." ; rdfs:label "Pigment deposition in the trabecular meshwork" ; rdfs:subClassOf obo:HP_0012630 . obo:HP_0012632 obo:IAO_0000115 "An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:20:17Z" ; oboInOwl:hasDbXref "MP:0005257", "SNOMEDCT_US:24075007", "UMLS:C0520999" ; oboInOwl:hasExactSynonym "Abnormal eye pressure", "Abnormal intraocular pressure" ; oboInOwl:id "HP:0012632" ; a owl:Class ; rdfs:label "Abnormal intraocular pressure" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0012633 obo:IAO_0000115 "A difference in the amount of intraocular pressure in the right and left eye." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:21:18Z" ; oboInOwl:hasDbXref "UMLS:C3805901" ; oboInOwl:id "HP:0012633" ; a owl:Class ; rdfs:label "Asymmetry of intraocular pressure" ; rdfs:subClassOf obo:HP_0012632 . obo:HP_0012634 obo:IAO_0000115 "Shedding of the pigment granules that normally adhere to the back of the iris into the aqueous humor." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:30:02Z" ; oboInOwl:hasDbXref "UMLS:C4022813" ; oboInOwl:id "HP:0012634" ; a owl:Class ; rdfs:comment "These pigment granules can accumulate in the trabucular meshwork and lead to increased intraocular pressure. That is coded separately as HP:001263." ; rdfs:label "Iris pigment dispersion" ; rdfs:subClassOf obo:HP_0008034 . obo:HP_0012635 obo:IAO_0000115 "Reduction in the amount of blood flow to the iris." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:41:07Z" ; oboInOwl:hasDbXref "UMLS:C4022812" ; oboInOwl:id "HP:0012635" ; a owl:Class ; rdfs:comment "This feature can be diagnosed by iris angiography." ; rdfs:label "Iris hypoperfusion" ; rdfs:subClassOf obo:HP_0007905 . obo:HP_0012636 obo:IAO_0000115 "Blockage of the retinal vein." ; dcterms:creator ; oboInOwl:creation_date "2014-01-17T11:43:32Z" ; oboInOwl:hasDbXref "MSH:D012170", "SNOMEDCT_US:46085004", "UMLS:C0035328" ; oboInOwl:id "HP:0012636" ; a owl:Class ; rdfs:comment "Retinal vein occlusion can lead to edema and ischemia of the retina." ; rdfs:label "Retinal vein occlusion" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0012637 obo:IAO_0000115 "High urine calcium in the presence of hypocalcemia." ; dcterms:creator ; oboInOwl:creation_date "2014-01-18T04:46:41Z" ; oboInOwl:hasDbXref "UMLS:C2673441" ; oboInOwl:hasExactSynonym "Kidney Ca wasting", "Kidney Ca2+ wasting", "Kidney calcium wasting", "Renal Ca wasting", "Renal Ca2+ wasting" ; oboInOwl:id "HP:0012637" ; a owl:Class ; rdfs:label "Renal calcium wasting" ; rdfs:subClassOf obo:HP_0011280 . obo:HP_0012638 obo:IAO_0000115 "A functional anomaly of the nervous system." ; dcterms:creator ; oboInOwl:creation_date "2014-01-19T08:02:46Z" ; oboInOwl:hasDbXref "UMLS:C4022811" ; oboInOwl:hasExactSynonym "Abnormality of nervous system physiology" ; oboInOwl:id "HP:0012638" ; a owl:Class ; rdfs:label "Abnormal nervous system physiology" ; rdfs:subClassOf obo:HP_0000707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012639 obo:IAO_0000115 "A structural anomaly of the nervous system." ; dcterms:creator ; oboInOwl:creation_date "2014-01-19T08:03:08Z" ; oboInOwl:hasDbXref "Fyler:4135", "Fyler:4300", "UMLS:C4022810" ; oboInOwl:hasExactSynonym "Abnormal shape of nervous system", "Abnormality of nervous system morphology" ; oboInOwl:id "HP:0012639" ; a owl:Class ; rdfs:label "Abnormal nervous system morphology" ; rdfs:subClassOf obo:HP_0000707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012640 obo:IAO_0000115 "A deviation from the norm of the intracranial pressure." ; dcterms:creator ; oboInOwl:creation_date "2014-01-19T08:06:51Z" ; oboInOwl:hasDbXref "UMLS:C4022809" ; oboInOwl:id "HP:0012640" ; a owl:Class ; rdfs:comment "Intracranial pressure (i.e., the pressure inside the skull) represents the pressue in the brain tissue and in the cerebrospinal fluid (CSF). Deviations from normal are generally identified by measuring the pressure of the CSF." ; rdfs:label "Abnormality of intracranial pressure" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0012641 obo:IAO_0000115 "A reduction of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2014-01-19T08:15:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:167714004", "SNOMEDCT_US:277657001", "UMLS:C0456892" ; oboInOwl:hasExactSynonym "Intracranial hypotension" ; oboInOwl:id "HP:0012641" ; a owl:Class ; rdfs:label "Decreased intracranial pressure" ; rdfs:subClassOf obo:HP_0012640 . obo:HP_0012642 obo:IAO_0000115 "Cerebellar agenesis is defined by the near complete absence of cerebellar tissue with only remnants of the anterior vermis, flocculus, and/or middle cerebellar peduncles." ; dcterms:creator ; oboInOwl:creation_date "2014-01-22T08:14:57Z" ; oboInOwl:hasDbXref "UMLS:C4022808" ; oboInOwl:id "HP:0012642" ; a owl:Class ; rdfs:comment "Usually, small remnants of the cerebellum are present; therefore the term subtotal cerebellar agenesis is also used in the literature. A secondary pontine hypoplasia is typically seen. The definition of cerebellar agenesis is based on the morphologic pattern and does not suggest the pathogenesis. Cerebellar agenesis may represent a malformation (e.g., mutations in PTF1A) or a disruption (e.g., hemorrhage that occurs during gestation or in the perinatal period, vascular insufficiency in Chiari II malformation and cerebellar herniation, and as a sequela of prematurity)." ; rdfs:label "Cerebellar agenesis" ; rdfs:subClassOf obo:HP_0007360 . obo:HP_0012643 obo:IAO_0000115 "Decreased amount of pigmentation in the fovea centralis." ; dcterms:creator ; oboInOwl:creation_date "2014-01-22T09:25:34Z" ; oboInOwl:hasDbXref "UMLS:C4022807" ; oboInOwl:id "HP:0012643" ; a owl:Class ; rdfs:label "Foveal hypopigmentation" ; rdfs:subClassOf obo:HP_0030493 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001786 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012644 obo:IAO_0000115 "An elevated concentration of lactate in the caudate nucleus. This finding can be elicited by magnetic resonance spectroscopy imaging." ; dcterms:creator ; oboInOwl:creation_date "2014-01-28T08:19:22Z" ; oboInOwl:hasDbXref "UMLS:C4022806" ; oboInOwl:id "HP:0012644" ; a owl:Class ; rdfs:label "Increased caudate lactate level" ; rdfs:subClassOf obo:HP_0002339 . obo:HP_0012645 obo:IAO_0000115 "Increase in size of a peripheral nerve. This finding can be appreciated by palpation along the axis of the nerve." ; dcterms:creator ; oboInOwl:creation_date "2014-02-01T12:44:16Z" ; oboInOwl:hasDbXref "UMLS:C2675074" ; oboInOwl:hasRelatedSynonym "Enlarged peripheral nerves" ; oboInOwl:id "HP:0012645" ; a owl:Class ; rdfs:comment "This feature can be appreciated by imaging studies (magnetic resonancy tomography), by palpation along the axis of a nerve, and by biopsy, and may be caused by axonal swelling or by myelin thickening. The differential diagnosis of enlarged peripheral nerves includes leprosy, hereditary motor and sensory neuropathy type 1 (about 30% of patients), but not type 2 (the axonal form), some other polyneuropathies, neurofibromatosis, and nerve tumors. A good review is available in Practical Neurology, 2003,3:40-45 by Michael Donaghy (no pubmed id)." ; rdfs:label "Enlarged peripheral nerve" ; rdfs:subClassOf obo:HP_0000759 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001021 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012646 obo:IAO_0000115 "A testis that is located at the upper scrotum or lower inguinal canal and that can be made to descend completely into the scrotum without resistance by manual reduction but returns to its original position by the cremasteric reflex." ; dcterms:creator ; oboInOwl:creation_date "2014-02-01T12:57:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:21779006", "UMLS:C0520578" ; oboInOwl:hasExactSynonym "Retractile testicle" ; oboInOwl:id "HP:0012646" ; a owl:Class ; rdfs:label "Retractile testis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0012647 obo:IAO_0000115 "Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." ; dcterms:creator ; oboInOwl:creation_date "2014-02-01T01:25:42Z" ; oboInOwl:hasDbXref "UMLS:C4022805" ; oboInOwl:hasExactSynonym "Abnormal inflammatory response" ; oboInOwl:id "HP:0012647" ; a owl:Class ; rdfs:label "Abnormal inflammatory response" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012648 obo:IAO_0000115 "An abnormal reduction in the inflammatory response to injury or infection." ; dcterms:creator ; oboInOwl:creation_date "2014-02-01T01:29:24Z" ; oboInOwl:hasDbXref "UMLS:C4022804" ; oboInOwl:hasExactSynonym "Decreased inflammatory response" ; oboInOwl:id "HP:0012648" ; a owl:Class ; rdfs:label "Decreased inflammatory response" ; rdfs:subClassOf obo:HP_0012647 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012649 obo:IAO_0000115 "A abnormal increase in the inflammatory response to injury or infection." ; dcterms:creator ; oboInOwl:creation_date "2014-02-01T01:29:58Z" ; oboInOwl:hasDbXref "UMLS:C4022803" ; oboInOwl:id "HP:0012649" ; a owl:Class ; rdfs:label "Increased inflammatory response" ; rdfs:subClassOf obo:HP_0012647 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0006954 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012650 obo:IAO_0000115 "Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly." ; dcterms:creator ; oboInOwl:creation_date "2014-02-06T07:47:51Z" ; oboInOwl:hasAlternativeId "HP:0007095" ; oboInOwl:hasDbXref "UMLS:C3279675" ; oboInOwl:hasExactSynonym "Frontoparietal polymicrogyria" ; oboInOwl:id "HP:0012650" ; a owl:Class ; rdfs:comment "The Sylvian fissure (also known as the lateral sulcus) separates the frontal and parietal lobes superiorly from the temporal lobe inferiorly." ; rdfs:label "Perisylvian polymicrogyria" ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0012651 obo:IAO_0000115 "A severe form of gait ataxia such that an affected person cannot walk at all." ; dcterms:creator ; oboInOwl:creation_date "2014-02-06T07:52:50Z" ; oboInOwl:hasDbXref "UMLS:C0877217" ; oboInOwl:id "HP:0012651" ; a owl:Class ; rdfs:label "Abasia" ; rdfs:subClassOf obo:HP_0002066 . obo:HP_0012652 obo:IAO_0000115 "Asthma attacks following exercise." ; dcterms:creator ; oboInOwl:creation_date "2014-02-12T10:42:14Z" ; oboInOwl:hasDbXref "MSH:D001250", "SNOMEDCT_US:31387002", "UMLS:C0004099" ; oboInOwl:hasExactSynonym "Exercise-induced asthma" ; oboInOwl:id "HP:0012652" ; a owl:Class ; rdfs:label "Exercise-induced asthma" ; rdfs:subClassOf obo:HP_0002099 . obo:HP_0012653 obo:IAO_0000115 "Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine." ; dcterms:creator ; oboInOwl:creation_date "2014-02-12T10:43:34Z" ; oboInOwl:hasDbXref "MSH:D013224", "SNOMEDCT_US:708090002", "UMLS:C0038218" ; oboInOwl:hasExactSynonym "Acute severe asthma" ; oboInOwl:id "HP:0012653" ; a owl:Class ; rdfs:label "Status asthmaticus" ; rdfs:subClassOf obo:HP_0002099 . obo:HP_0012654 obo:IAO_0000115 "Abnormal concentration of dopamine in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T10:35:24Z" ; oboInOwl:hasDbXref "UMLS:C4022802" ; oboInOwl:hasExactSynonym "Abnormal CSF dopamine level" ; oboInOwl:id "HP:0012654" ; a owl:Class ; rdfs:label "Abnormal CSF dopamine concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012655 obo:IAO_0000115 "Increased concentration of dopamine in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T10:36:53Z" ; oboInOwl:hasDbXref "UMLS:C4022801" ; oboInOwl:id "HP:0012655" ; a owl:Class ; rdfs:label "Elevated CSF dopamine concentration" ; rdfs:subClassOf obo:HP_0012654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012656 obo:IAO_0000115 "Decreased concentration of dopamine in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T10:37:27Z" ; oboInOwl:hasDbXref "UMLS:C4022800" ; oboInOwl:id "HP:0012656" ; a owl:Class ; rdfs:label "Reduced CSF dopamine concentration" ; rdfs:subClassOf obo:HP_0012654 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012657 obo:IAO_0000115 "A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:22:18Z" ; oboInOwl:hasDbXref "UMLS:C4022799" ; oboInOwl:hasExactSynonym "Abnormal brain PET scan" ; oboInOwl:id "HP:0012657" ; a owl:Class ; rdfs:comment "Note that while structural brain anomalies can cause abnormal brain PET scan results, structural abnormalities are detectable by multiple neuroimaging modalities and should be coded using terms from the hierarchy under 'Abnormality of nervous system morphology' (HP:0012639)." ; rdfs:label "Abnormal brain positron emission tomography" ; rdfs:subClassOf obo:HP_0410263 . obo:HP_0012658 obo:IAO_0000115 "An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:29:38Z" ; oboInOwl:hasDbXref "UMLS:C4022798" ; oboInOwl:hasExactSynonym "Abnormal brain FDG PET scan" ; oboInOwl:id "HP:0012658" ; a owl:Class ; rdfs:label "Abnormal brain FDG positron emission tomography" ; rdfs:subClassOf obo:HP_0012657 . obo:HP_0012659 obo:IAO_0000115 "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:33:12Z" ; oboInOwl:hasDbXref "UMLS:C4022797" ; oboInOwl:id "HP:0012659" ; a owl:Class ; rdfs:comment "Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the prefrontal cortex." ; rdfs:label "Prefrontal hypometabolism in FDG PET" ; rdfs:subClassOf obo:HP_0012658 . obo:HP_0012660 obo:IAO_0000115 "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:35:25Z" ; oboInOwl:hasDbXref "UMLS:C4022796" ; oboInOwl:id "HP:0012660" ; a owl:Class ; rdfs:comment "Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the thalamus." ; rdfs:label "Thalamic hypometabolism in FDG PET" ; rdfs:subClassOf obo:HP_0012658 . obo:HP_0012661 obo:IAO_0000115 "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:37:59Z" ; oboInOwl:hasDbXref "UMLS:C4022795" ; oboInOwl:id "HP:0012661" ; a owl:Class ; rdfs:comment "Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the hypothalamus." ; rdfs:label "Hypothalamic hypometabolism in FDG PET" ; rdfs:subClassOf obo:HP_0012658 . obo:HP_0012662 obo:IAO_0000115 "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T11:45:41Z" ; oboInOwl:hasDbXref "UMLS:C4022794" ; oboInOwl:id "HP:0012662" ; a owl:Class ; rdfs:comment "Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the parietal cortex." ; rdfs:label "Parietal hypometabolism in FDG PET" ; rdfs:subClassOf obo:HP_0012658 . obo:HP_0012663 obo:IAO_0000115 "A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:06:28Z" ; oboInOwl:hasDbXref "UMLS:C4022793" ; oboInOwl:hasExactSynonym "Mildly reduced ejection fraction" ; oboInOwl:id "HP:0012663" ; a owl:Class ; rdfs:label "Mildly reduced left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0012664 . obo:HP_0012664 obo:IAO_0000115 "A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:03:37Z" ; oboInOwl:hasDbXref "UMLS:C4022792" ; oboInOwl:hasExactSynonym "Reduced ejection fraction" ; oboInOwl:id "HP:0012664" ; a owl:Class ; rdfs:comment "The normal range is at least 55 percent." ; rdfs:label "Reduced left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0025169, obo:HP_0034314 . obo:HP_0012665 obo:IAO_0000115 "A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle, defined as a left ventricular ejection fraction of 30-39 percent." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:08:33Z" ; oboInOwl:hasDbXref "UMLS:C4022791" ; oboInOwl:hasExactSynonym "Moderately reduced ejection fraction" ; oboInOwl:id "HP:0012665" ; a owl:Class ; rdfs:comment "The normal range in adults is over 50 percent, and a moderate reduction can be defined as 30-39 percent." ; rdfs:label "Moderately reduced left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0012664 . obo:HP_0012666 obo:IAO_0000115 "A large reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at over 50 percent, and a severe reduction is defined as less than 30 percent." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:09:02Z" ; oboInOwl:hasDbXref "UMLS:C4022790" ; oboInOwl:hasExactSynonym "Severely reduced ejection fraction" ; oboInOwl:id "HP:0012666" ; a owl:Class ; rdfs:label "Severely reduced left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0012664 . obo:HP_0012667 obo:IAO_0000115 "An abnormal motion of a segment of the left ventricle during the cardiac cycle." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:12:48Z" ; oboInOwl:hasDbXref "UMLS:C4022789" ; oboInOwl:id "HP:0012667" ; a owl:Class ; rdfs:comment "This feature can be appreciated using color kinesis, which tracks the motion of the endocardium in real time throughout systole and results in color-encoded images reflecting the magnitude and timing of endocardial motion." ; rdfs:label "Regional left ventricular wall motion abnormality" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0012668 dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:33:13Z" ; oboInOwl:hasDbXref "MSH:D013575", "MSH:D019462", "SNOMEDCT_US:234167006", "SNOMEDCT_US:398652001", "SNOMEDCT_US:398665005", "UMLS:C0042420", "UMLS:C0340854" ; oboInOwl:hasExactSynonym "Neurocardiogenic syncope", "Reflex syncope", "Situational syncope" ; oboInOwl:id "HP:0012668" ; a owl:Class ; rdfs:label "Vasovagal syncope" ; rdfs:subClassOf obo:HP_0001279 . obo:HP_0012669 obo:IAO_0000115 "An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:39:14Z" ; oboInOwl:hasDbXref "MSH:D013575", "SNOMEDCT_US:51723007", "UMLS:C0221046" ; oboInOwl:id "HP:0012669" ; a owl:Class ; rdfs:comment "Carotid sinus syncope cam be elicited mechanical manipulation of the carotid sinuses (eg, taking pulses in the neck, shaving)." ; rdfs:label "Carotid sinus syncope" ; rdfs:subClassOf obo:HP_0001279 . obo:HP_0012670 obo:IAO_0000115 "Syncope following a quick change in position from lying down to standing." ; dcterms:creator ; oboInOwl:creation_date "2014-02-15T01:41:57Z" ; oboInOwl:hasDbXref "UMLS:C0749201" ; oboInOwl:id "HP:0012670" ; a owl:Class ; rdfs:label "Orthostatic syncope" ; rdfs:subClassOf obo:HP_0001279 . obo:HP_0012671 obo:IAO_0000115 "Poverty of behavior and speech output, lack of initiative, loss of emotional responses, psychomotor slowing, and prolonged speech latency." ; dcterms:creator ; oboInOwl:creation_date "2014-02-27T10:48:32Z" ; oboInOwl:hasDbXref "UMLS:C0919974" ; oboInOwl:hasExactSynonym "Aboulia" ; oboInOwl:id "HP:0012671" ; a owl:Class ; rdfs:comment "Abulia is less severe thana kinetic mutism, and more so than apathy." ; rdfs:label "Abulia" ; rdfs:subClassOf obo:HP_0000745 . obo:HP_0012672 obo:IAO_0000115 "Akinetic mutism is essentially characterized by a total absence of spontaneous behavior and speech occurring in the presence of preserved visual tracking." ; dcterms:creator ; oboInOwl:creation_date "2014-02-27T10:50:59Z" ; oboInOwl:hasDbXref "MSH:D000405", "SNOMEDCT_US:53333005", "UMLS:C0001889" ; oboInOwl:id "HP:0012672" ; a owl:Class ; rdfs:label "Akinetic mutism" ; rdfs:subClassOf obo:HP_0000745 . obo:HP_0012673 obo:IAO_0000115 "A failure to develop of the upper vagina." ; dcterms:creator ; oboInOwl:creation_date "2014-02-27T11:00:26Z" ; oboInOwl:hasDbXref "UMLS:C4022788" ; oboInOwl:hasExactSynonym "Absent upper vagina" ; oboInOwl:id "HP:0012673" ; a owl:Class ; rdfs:comment "The female reproductive tract primarily develops from the Mullerian ducts (MD), which form as an invagination of the coelomic epithelium and further develop into the upper two-thirds of the vagina, the uterus and the Fallopian tubes. Complete aplasia of the uterus, cervix, and upper vagina is termed Mullerian aplasia. This term refers to the aplasia of the upper roughly two thirds of the vagina that is characteristic of Mullerian aplasia." ; rdfs:label "Aplasia of the upper vagina" ; rdfs:subClassOf obo:HP_0003250 . obo:HP_0012674 obo:IAO_0000115 "A failure to develop of the lower part of the vagina." ; dcterms:creator ; oboInOwl:creation_date "2014-02-27T11:09:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253834007", "UMLS:C0431646" ; oboInOwl:hasExactSynonym "Absent lower vagina", "Agenesis of the lower vagina" ; oboInOwl:id "HP:0012674" ; a owl:Class ; rdfs:label "Aplasia of the lower vagina" ; rdfs:subClassOf obo:HP_0003250 . obo:HP_0012675 obo:IAO_0000115 "An abnormal build up of iron (Fe) in brain tissue." ; dcterms:creator ; oboInOwl:creation_date "2014-03-13T07:22:40Z" ; oboInOwl:hasDbXref "UMLS:C4021076" ; oboInOwl:hasExactSynonym "Brain iron deposition", "Iron accumulation in brain" ; oboInOwl:id "HP:0012675" ; a owl:Class ; rdfs:label "Iron accumulation in brain" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012676 obo:IAO_0000115 "An anomalous build up of copper (Cu) in the brain." ; oboInOwl:creation_date "2014-03-13T07:28:03Z" ; oboInOwl:hasDbXref "UMLS:C4022787" ; oboInOwl:hasExactSynonym "Brain copper accumulation", "Copper accumulation in brain" ; oboInOwl:id "HP:0012676" ; a owl:Class ; rdfs:label "Copper accumulation in brain" ; rdfs:subClassOf obo:HP_0012443, obo:HP_0032243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012677 obo:IAO_0100001 "HP:0002454" ; dcterms:creator ; oboInOwl:creation_date "2014-03-13T07:29:37Z" ; oboInOwl:id "HP:0012677" ; a owl:Class ; rdfs:label "obsolete Iron accumulation in globus pallidus" ; owl:deprecated true . obo:HP_0012678 obo:IAO_0000115 "An anomalous build up of iron (Fe) in the substantia nigra." ; dcterms:creator ; oboInOwl:creation_date "2014-03-13T07:29:54Z" ; oboInOwl:hasDbXref "UMLS:C4022785" ; oboInOwl:id "HP:0012678" ; a owl:Class ; rdfs:label "Iron accumulation in substantia nigra" ; rdfs:subClassOf obo:HP_0012675, obo:HP_0045007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002038 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012679 obo:IAO_0000115 "An increase in the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T12:41:17Z" ; oboInOwl:hasDbXref "UMLS:C4022784" ; oboInOwl:id "HP:0012679" ; a owl:Class ; rdfs:label "Widened interpedicular distance" ; rdfs:subClassOf obo:HP_0008438 . obo:HP_0012680 obo:IAO_0000115 "An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T12:46:36Z" ; oboInOwl:hasDbXref "UMLS:C4022783" ; oboInOwl:id "HP:0012680" ; a owl:Class ; rdfs:label "Abnormality of the pineal gland" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012681 obo:IAO_0000115 "A structural abnormality of the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T12:50:21Z" ; oboInOwl:hasDbXref "UMLS:C4022782" ; oboInOwl:hasExactSynonym "Abnormality of pineal morphology" ; oboInOwl:id "HP:0012681" ; a owl:Class ; rdfs:comment "The pineal gland typically measures 7 x 6 x 3mm in size and is located in a groove between the laterally placed thalamic bodies." ; rdfs:label "Abnormal pineal morphology" ; rdfs:subClassOf obo:HP_0012443, obo:HP_0012680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012682 obo:IAO_0000115 "Accumulation of calcium salts in the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T12:51:57Z" ; oboInOwl:hasDbXref "UMLS:C1398718" ; oboInOwl:id "HP:0012682" ; a owl:Class ; rdfs:comment "This feature can be appreciated on skull radiography." ; rdfs:label "Pineal gland calcification" ; rdfs:subClassOf obo:HP_0012681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012683 obo:IAO_0000115 "A glial uniloculated or multiloculated fluid-filled sac that either reside within or completely replace the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:01:45Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:413099000", "UMLS:C1335411" ; oboInOwl:id "HP:0012683" ; a owl:Class ; rdfs:comment "Pineal cysts are benign and often asymptomatic lesions. They are typically visualized by computed tomography or magnetic resonance imaging." ; rdfs:label "Pineal cyst" ; rdfs:subClassOf obo:HP_0010576, obo:HP_0012681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012684 obo:IAO_0000115 "An abnormal increase or decrease in the quantity of three-dimensional space taken up by the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:08:48Z" ; oboInOwl:hasDbXref "UMLS:C4022781" ; oboInOwl:id "HP:0012684" ; a owl:Class ; rdfs:comment "This feature is typically assessed by magnetic resonance tomography of the brain." ; rdfs:label "Abnormal pineal volume" ; rdfs:subClassOf obo:HP_0012681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000918 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012685 obo:IAO_0000115 "An abnormal reduction in the quantity of three-dimensional space taken up by the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:10:12Z" ; oboInOwl:hasDbXref "UMLS:C4022780" ; oboInOwl:id "HP:0012685" ; a owl:Class ; rdfs:label "Decreased pineal volume" ; rdfs:subClassOf obo:HP_0012684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012686 obo:IAO_0000115 "An abnormal elevation in the quantity of three-dimensional space taken up by the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:11:33Z" ; oboInOwl:hasDbXref "UMLS:C4022779" ; oboInOwl:id "HP:0012686" ; a owl:Class ; rdfs:label "Increased pineal volume" ; rdfs:subClassOf obo:HP_0012684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000595 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012687 obo:IAO_0000115 "Failure to develop of the pineal gland, defined clinically as the absence of the pineal gland with no indication of the pineal gland even having been present." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:13:13Z" ; oboInOwl:hasDbXref "UMLS:C3553078" ; oboInOwl:id "HP:0012687" ; a owl:Class ; rdfs:label "Agenesis of pineal gland" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0012681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012688 obo:IAO_0000115 "A functional abnormality of the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:15:36Z" ; oboInOwl:hasDbXref "UMLS:C4022778" ; oboInOwl:id "HP:0012688" ; a owl:Class ; rdfs:label "Abnormality of pineal physiology" ; rdfs:subClassOf obo:HP_0012638, obo:HP_0012680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012689 obo:IAO_0000115 "An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T01:16:40Z" ; oboInOwl:hasDbXref "UMLS:C4022777" ; oboInOwl:id "HP:0012689" ; a owl:Class ; rdfs:comment "The rhythm of melatonin synthesized in and released from the pineal gland is characterized by a prominent nocturnal peak, which also contains temporal information that had originated in the suprachiasmatic nucleus. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neurological and stressful conditions, pain, cardiovascular diseases, cases of cancer, endocrine and metabolic disorders, in particular diabetes type 2." ; rdfs:label "Abnormal pineal melatonin secretion" ; rdfs:subClassOf obo:HP_0012688 . obo:HP_0012690 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a diffuse hypointensity affecting the entire thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T04:32:50Z" ; oboInOwl:hasDbXref "UMLS:C4022776" ; oboInOwl:id "HP:0012690" ; a owl:Class ; rdfs:label "T2 hypointense thalamus" ; rdfs:subClassOf obo:HP_0012696 . obo:HP_0012691 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hypointensity affecting a particular region of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T04:52:32Z" ; oboInOwl:hasDbXref "UMLS:C4022775" ; oboInOwl:id "HP:0012691" ; a owl:Class ; rdfs:label "Focal T2 hypointense thalamic lesion" ; rdfs:subClassOf obo:HP_0012696 . obo:HP_0012692 obo:IAO_0000115 "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hyperintensity affecting a particular region of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T04:54:03Z" ; oboInOwl:hasDbXref "UMLS:C4022774" ; oboInOwl:id "HP:0012692" ; a owl:Class ; rdfs:comment "The term \"unidentified bright object\" has been used to describe T2 hyperintense lesions in the thalamus and elsewhere in patients with neurofibromatosis." ; rdfs:label "Focal T2 hyperintense thalamic lesion" ; rdfs:subClassOf obo:HP_0012696 . obo:HP_0012693 obo:IAO_0000115 "Deviation from the normal range of size of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T05:45:51Z" ; oboInOwl:hasDbXref "UMLS:C4022773" ; oboInOwl:id "HP:0012693" ; a owl:Class ; rdfs:label "Abnormal thalamic size" ; rdfs:subClassOf obo:HP_0010663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012694 obo:IAO_0000115 "An increase in the quantity of space occupied by the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T05:47:14Z" ; oboInOwl:hasDbXref "UMLS:C4022772" ; oboInOwl:id "HP:0012694" ; a owl:Class ; rdfs:label "Enlarged thalamic volume" ; rdfs:subClassOf obo:HP_0012693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012695 obo:IAO_0000115 "A reduction in the quantity of space occupied by the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T05:48:28Z" ; oboInOwl:hasDbXref "UMLS:C4022771" ; oboInOwl:id "HP:0012695" ; a owl:Class ; rdfs:label "Decreased thalamic volume" ; rdfs:subClassOf obo:HP_0012693 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000596 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012696 obo:IAO_0000115 "A deviation from normal signal on magnetic resonance imaging (MRI) of the thalamus." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T05:49:08Z" ; oboInOwl:hasDbXref "UMLS:C4022770" ; oboInOwl:id "HP:0012696" ; a owl:Class ; rdfs:label "Abnormal thalamic MRI signal intensity" ; rdfs:subClassOf obo:HP_0010663 . obo:HP_0012697 obo:IAO_0000115 "Decreased size of the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:01:22Z" ; oboInOwl:hasDbXref "UMLS:C4022769" ; oboInOwl:id "HP:0012697" ; a owl:Class ; rdfs:label "Small basal ganglia" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012698 obo:IAO_0000115 "Focal proliferation of glial cells in the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:03:03Z" ; oboInOwl:hasDbXref "UMLS:C4022768" ; oboInOwl:id "HP:0012698" ; a owl:Class ; rdfs:label "Cerebellar gliosis" ; rdfs:subClassOf obo:HP_0001317, obo:HP_0002171 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012699 obo:IAO_0000115 "A structural abnormality of a diaphysis of the leg." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:14:15Z" ; oboInOwl:hasDbXref "UMLS:C4022767" ; oboInOwl:hasExactSynonym "Anomaly of shaft of long bone of lower limb" ; oboInOwl:id "HP:0012699" ; a owl:Class ; rdfs:label "Anomaly of lower limb diaphyses" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012476 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012700 obo:IAO_0000115 "A functional anomaly of the large intestine." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:20:38Z" ; oboInOwl:hasDbXref "UMLS:C4022766" ; oboInOwl:id "HP:0012700" ; a owl:Class ; rdfs:label "Abnormal large intestine physiology" ; rdfs:subClassOf obo:HP_0025032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012701 obo:IAO_0000115 "A sudden, irresistible need to have a bowel movement." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:22:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:71820002", "UMLS:C0426636" ; oboInOwl:hasExactSynonym "Faecal urgency", "Fecal urgency" ; oboInOwl:id "HP:0012701" ; a owl:Class ; rdfs:label "Bowel urgency" ; rdfs:subClassOf obo:HP_0012700 . obo:HP_0012702 obo:IAO_0000115 "A repeated, painful urge to defecate without excreting stool." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T06:23:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:267053000", "SNOMEDCT_US:6548007", "UMLS:C0232726" ; oboInOwl:id "HP:0012702" ; a owl:Class ; rdfs:label "Tenesmus" ; rdfs:subClassOf obo:HP_0012700 . obo:HP_0012703 obo:IAO_0000115 "Abnormality in the space in the meninges beneath the arachnoid membrane and above the pia mater that contains the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T07:45:24Z" ; oboInOwl:hasDbXref "UMLS:C4022765" ; oboInOwl:hasExactSynonym "Abnormality of the subarachnoid space" ; oboInOwl:id "HP:0012703" ; a owl:Class ; rdfs:label "Abnormal subarachnoid space morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012704 obo:IAO_0000115 "An increase in size of the anatomic space between the arachnoid membrane and pia mater." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T07:59:21Z" ; oboInOwl:hasDbXref "UMLS:C1846151" ; oboInOwl:hasExactSynonym "Enlarged subarachnoid space" ; oboInOwl:hasRelatedSynonym "Widened subarachnoid spaces" ; oboInOwl:id "HP:0012704" ; a owl:Class ; rdfs:label "Widened subarachnoid space" ; rdfs:subClassOf obo:HP_0012703 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012705 obo:IAO_0000115 "An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS)." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T08:04:18Z" ; oboInOwl:hasDbXref "UMLS:C4022764" ; oboInOwl:id "HP:0012705" ; a owl:Class ; rdfs:comment "MRS can only detect a few metabolites as least millimolar concentrations are necessary for the metabolites to be detected. The major brain metabolites detected are choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lactate, myo-inositol, glutamine and glutamate, lipids, and the amino acids leucine and alanine." ; rdfs:label "Abnormal metabolic brain imaging by MRS" ; rdfs:subClassOf obo:HP_0410263 . obo:HP_0012706 obo:IAO_0000115 "An increase in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS)." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T08:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022763" ; oboInOwl:id "HP:0012706" ; a owl:Class ; rdfs:comment "The Choline (Cho) peak is a heterogeneous peak representing various choline-containing compounds such as acetylcholine, phosphocholine (lecithin), glycerophosphocholine, and various other intermediates of phospholipids metabolism. It is an indicator of cell density and cell wall turnover. Elevated levels are found in tumors, especially malignant ones, and in certain demyelinating diseases. Choline resonance presents at 3.22 ppm. Studies have shown there is also a direct association between Cho and levels of Ki-67, a protein expressed in all phases of the cell cycle except GO that serves as a good marker for cellular proliferation. This observation makes Cho a reliable predictor of cellular activity in tumor tissue." ; rdfs:label "Elevated brain choline level by MRS" ; rdfs:subClassOf obo:HP_0025047 . obo:HP_0012707 obo:IAO_0000115 "An increase in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T08:08:20Z" ; oboInOwl:hasDbXref "UMLS:C4022762" ; oboInOwl:id "HP:0012707" ; a owl:Class ; rdfs:comment "Lactate (Lac) is absent in normal brain tissue and its presence is indicative of anerobic glycolysis at the cellular level. Elevated levels are associated with ischemic conditions or metabolic disorders (where anerobic glycolysis predominates) but is also noted at the edges of large brain tumors. The peak is very sensitive to the technique employed and unless the correct echo time is employed, it may be artifactually suppressed. The spectral peak lies at 1:33 ppm. The peak is often inverted or bifid." ; rdfs:label "Elevated brain lactate level by MRS" ; rdfs:subClassOf obo:HP_0025045 . obo:HP_0012708 obo:IAO_0000115 "A decrease in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T08:09:12Z" ; oboInOwl:hasDbXref "UMLS:C4022761" ; oboInOwl:hasExactSynonym "MR Spectroscopy: N-acetylaspartate low in brain", "Reduced brain N-acetyl aspartate level by magnetic resonance spectroscopy" ; oboInOwl:id "HP:0012708" ; a owl:Class ; rdfs:comment "N-Acetyl Aspartate (NAA) is an amino acid found exclusively in neurons. It is regarded as a non-specific marker and is thought to be involved in Coenzyme A interactions and lipogenesis within the brain. It is a marker of neuronal viability. Normal NAA concentration is in the range of 8-9 mmol/kg in healthy adult brain. Concentrations are decreased in conditions leading to axonal injury or neuronal loss. NAA is also decreased in other conditions such as neoplasm, infarction, and inflammatory conditions such as multiple sclerosis. NAA peak is seen at 2.0 ppm (parts per million) on MR spectra." ; rdfs:label "Reduced brain N-acetyl aspartate level by MRS" ; rdfs:subClassOf obo:HP_0025052 . obo:HP_0012709 obo:IAO_0000115 "A deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dcterms:creator ; oboInOwl:creation_date "2014-03-22T08:12:15Z" ; oboInOwl:hasDbXref "UMLS:C4022760" ; oboInOwl:id "HP:0012709" ; a owl:Class ; rdfs:comment "Creatine (Cr) is related to cell energy pathways, being both the substrate and product of creatine kinase. Creatine reflects the energy potential available in brain tissue. Its concentration in normal brain remains very high and stable due to high metabolic energy needs of brain cells. Its peak is noticed at 3.0 ppm. Creatine-Choline ratios are an important indicator of disease states such as demyelization." ; rdfs:label "Abnormal brain choline/creatine ratio by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0012710 obo:IAO_0000115 "Excessive growth of a nail laterally into the nail fold." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:09:47Z" ; oboInOwl:hasDbXref "MSH:D009263", "SNOMEDCT_US:400097005", "SNOMEDCT_US:400200009", "UMLS:C0027343" ; oboInOwl:hasExactSynonym "Ingrown nail" ; oboInOwl:id "HP:0012710" ; a owl:Class ; rdfs:label "Ingrown nail" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0012711 obo:IAO_0000115 "A delay in the process of formation and maturation of the epiphysis of one or more vertebrae." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:27:51Z" ; oboInOwl:hasDbXref "UMLS:C4022759", "UMLS:C4280312" ; oboInOwl:hasRelatedSynonym "Delayed maturation of the end part of the vertebral bone" ; oboInOwl:id "HP:0012711" ; a owl:Class ; rdfs:label "Delayed ossification of vertebral epiphysis" ; rdfs:subClassOf obo:HP_0100569 . obo:HP_0012712 obo:IAO_0000115 "The presence of a mild form of hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:33:46Z" ; oboInOwl:hasDbXref "UMLS:C4022758" ; oboInOwl:hasExactSynonym "Mild hearing impairment" ; oboInOwl:id "HP:0012712" ; a owl:Class ; rdfs:label "Mild hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012713 obo:IAO_0000115 "The presence of a moderate form of hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:35:59Z" ; oboInOwl:hasDbXref "UMLS:C4022757" ; oboInOwl:hasExactSynonym "Moderate hearing impairment" ; oboInOwl:id "HP:0012713" ; a owl:Class ; rdfs:label "Moderate hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012714 obo:IAO_0000115 "A severe form of hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:37:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:3561000119106", "UMLS:C3874334" ; oboInOwl:hasExactSynonym "Severe deafness", "Severe hearing impairment", "Severe hearing loss" ; oboInOwl:id "HP:0012714" ; a owl:Class ; rdfs:label "Severe hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012715 obo:IAO_0000115 "A profound (essentially complete) form of hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:38:39Z" ; oboInOwl:hasDbXref "UMLS:C4022756" ; oboInOwl:hasExactSynonym "Profound hearing impairment" ; oboInOwl:id "HP:0012715" ; a owl:Class ; rdfs:label "Profound hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012716 obo:IAO_0000115 "The presence of a moderate form of conductive hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:40:05Z" ; oboInOwl:hasDbXref "UMLS:C4021075" ; oboInOwl:hasExactSynonym "Conductive hearing loss, moderate" ; oboInOwl:id "HP:0012716" ; a owl:Class ; rdfs:comment "Conductive hearing impairment with 21-40 dB deficit." ; rdfs:label "Moderate conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405, obo:HP_0012712, obo:HP_0012713 . obo:HP_0012717 obo:IAO_0000115 "A severe form of conductive hearing impairment." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T12:40:51Z" ; oboInOwl:hasDbXref "UMLS:C4021074" ; oboInOwl:hasExactSynonym "Conductive hearing loss, severe" ; oboInOwl:id "HP:0012717" ; a owl:Class ; rdfs:comment "Conductive hearing impairment with 21-40 dB deficit." ; rdfs:label "Severe conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405, obo:HP_0012712, obo:HP_0012714 . obo:HP_0012718 obo:IAO_0000115 "Abnormal structure of the gastrointestinal tract." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:09:02Z" ; oboInOwl:hasDbXref "UMLS:C4021073" ; oboInOwl:hasExactSynonym "Abnormal shape of the digestive system", "Morphological abnormality of the GI tract", "Morphological anomaly of the digestive system" ; oboInOwl:id "HP:0012718" ; a owl:Class ; rdfs:label "Morphological abnormality of the gastrointestinal tract" ; rdfs:subClassOf obo:HP_0011024, obo:HP_0025033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012719 obo:IAO_0000115 "Abnormal functionality of the gastrointestinal tract." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:10:47Z" ; oboInOwl:hasDbXref "UMLS:C4022755" ; oboInOwl:hasExactSynonym "Functional abnormality of the GI tract", "GI dysfunction" ; oboInOwl:id "HP:0012719" ; a owl:Class ; rdfs:label "Functional abnormality of the gastrointestinal tract" ; rdfs:subClassOf obo:HP_0011024, obo:HP_0025032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005409 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012720 obo:IAO_0000115 "Tumor (An abnormal mass of tissue resulting from abnormally dividing cells) of the nasal cavity." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:16:06Z" ; oboInOwl:hasAlternativeId "HP:0100637" ; oboInOwl:hasDbXref "MSH:D009669", "NCIT:C3262", "SNOMEDCT_US:126669004", "UMLS:C0028433", "UMLS:C0751394" ; oboInOwl:hasExactSynonym "Nasal neoplasm", "Nasal tumor", "Nasal tumour", "Neoplasia of the nose", "Nose cancer", "Tumor of the nose", "Tumour of the nose" ; oboInOwl:id "HP:0012720" ; a owl:Class ; rdfs:label "Neoplasm of the nose" ; rdfs:subClassOf obo:HP_0012289, obo:HP_0100630 . obo:HP_0012721 obo:IAO_0000115 "A vascular malformation resulting from a developmental error of venous tissue composed of dysmorphic channels lined by flattened endothelium and exhibiting slow turnover. A venous malformation may present as a blue patch on the skin ranging to a soft blue mass. Venous malformations are easily compressible and usually swell in thewhen venous pressure increases (e.g., when held in a dependent position or when a child cries). They may be relatively localized or quite extensive within an anatomic region." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:20:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:297222002", "UMLS:C2937220" ; oboInOwl:hasExactSynonym "Venous malformations" ; oboInOwl:id "HP:0012721" ; a owl:Class ; rdfs:comment "Venous malformations are always present at birth, and usually involve the skin of the face, limbs, or trunk." ; rdfs:label "Venous malformation" ; rdfs:subClassOf obo:HP_0002624 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000646 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012722 obo:IAO_0000115 "Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:32:14Z" ; oboInOwl:hasDbXref "MSH:D006327", "SNOMEDCT_US:233916004", "UMLS:C0018794" ; oboInOwl:id "HP:0012722" ; a owl:Class ; rdfs:label "Heart block" ; rdfs:subClassOf obo:HP_0031546 . obo:HP_0012723 obo:IAO_0000115 "Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:34:01Z" ; oboInOwl:hasDbXref "Fyler:7014", "MSH:D012848", "SNOMEDCT_US:65778007", "UMLS:C0037188" ; oboInOwl:id "HP:0012723" ; a owl:Class ; rdfs:comment "Sinoatrial block is characterized by a delayed in heartbeat and pauses between P waves as demonstrated by electrocardiography." ; rdfs:label "Sinoatrial block" ; rdfs:subClassOf obo:HP_0011702, obo:HP_0012722 . obo:HP_0012724 obo:IAO_0000115 "Edema in the region of the upper eyelid." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:38:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:700339006", "UMLS:C2025988", "UMLS:C3839407" ; oboInOwl:hasExactSynonym "Cellulitis of upper eyelid", "Fullness of upper eyelid", "Puffiness of upper eyelid", "Swelling of upper eyelid", "Upper eyelid oedema" ; oboInOwl:id "HP:0012724" ; a owl:Class ; rdfs:label "Upper eyelid edema" ; rdfs:subClassOf obo:HP_0100540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001712 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012725 obo:IAO_0000115 "A soft tissue continuity in the A/P axis between two digits that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two digits that lies significantly distal to the flexion crease that overlies the metacarpophalangeal or metatarsophalangeal joint of the adjacent digits." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T01:40:45Z" ; oboInOwl:hasDbXref "UMLS:C1861921" ; oboInOwl:hasExactSynonym "Cutaneous syndactyly of digits", "Syndactyly, cutaneous" ; oboInOwl:id "HP:0012725" ; a owl:Class ; rdfs:label "Cutaneous syndactyly" ; rdfs:subClassOf obo:HP_0001159 . obo:HP_0012726 obo:IAO_0000115 "An abnormally decreased potassium concentration in the blood occurring periodically with a return to normal between the episodes." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:08:24Z" ; oboInOwl:hasDbXref "UMLS:C4022754" ; oboInOwl:hasExactSynonym "Recurrent low potassium" ; oboInOwl:id "HP:0012726" ; a owl:Class ; rdfs:label "Episodic hypokalemia" ; rdfs:subClassOf obo:HP_0002900 . obo:HP_0012727 obo:IAO_0000115 "An abnormal localized widening (dilatation) of the thoracic aorta." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:22:20Z" ; oboInOwl:hasBroadSynonym "Dilatation of the thoracic aorta" ; oboInOwl:hasDbXref "MSH:D017545", "SNOMEDCT_US:433068007", "UMLS:C0162872" ; oboInOwl:id "HP:0012727" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Thoracic aortic aneurysm" ; rdfs:subClassOf obo:HP_0004942 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ] ) ] ] ) ] ] . obo:HP_0012728 obo:IAO_0000115 "A concentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves the full circumference of the vessel wall" ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:26:12Z" ; oboInOwl:hasBroadSynonym "Dilatation of the fusiform descending thoracic aorta" ; oboInOwl:hasDbXref "UMLS:C4022753" ; oboInOwl:id "HP:0012728" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Fusiform descending thoracic aortic aneurysm" ; rdfs:subClassOf obo:HP_0004959 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0002400 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002345 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012729 obo:IAO_0000115 "An eccentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves only a portion of the circumference of the vessel wall" ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:27:11Z" ; oboInOwl:hasBroadSynonym "Dilatation of the saccular descending thoracic aorta" ; oboInOwl:hasDbXref "UMLS:C4022752" ; oboInOwl:id "HP:0012729" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Saccular descending thoracic aortic aneurysm" ; rdfs:subClassOf obo:HP_0004959 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0001987 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002345 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012730 obo:IAO_0000115 "Absence of the tongue owing to a developmental abnormality." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:30:53Z" ; oboInOwl:hasBroadSynonym "Missing tongue" ; oboInOwl:hasDbXref "SNOMEDCT_US:74788000", "UMLS:C0158663" ; oboInOwl:hasExactSynonym "Absence of tongue", "Failure of development of tongue" ; oboInOwl:id "HP:0012730" ; a owl:Class ; rdfs:label "Aglossia" ; rdfs:subClassOf obo:HP_0010295 . obo:HP_0012731 obo:IAO_0000115 "Abnormal anatomic location of the anterior pituitary gland." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:41:41Z" ; oboInOwl:hasAlternativeId "HP:0011765" ; oboInOwl:hasDbXref "UMLS:C4022751" ; oboInOwl:id "HP:0012731" ; a owl:Class ; rdfs:label "Ectopic anterior pituitary gland" ; rdfs:subClassOf obo:HP_0011747 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002196 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012732 obo:IAO_0000115 "An abnormality of the anus or rectum." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:48:00Z" ; oboInOwl:hasDbXref "MSH:D000071056", "SNOMEDCT_US:33225004", "UMLS:C3495676" ; oboInOwl:id "HP:0012732" ; a owl:Class ; rdfs:label "Anorectal anomaly" ; rdfs:subClassOf obo:HP_0012718 . obo:HP_0012733 obo:IAO_0000115 "A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T02:54:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:112629002", "UMLS:C0332573" ; oboInOwl:hasExactSynonym "Flat, discolored area of skin", "Flat, discoloured area of skin" ; oboInOwl:id "HP:0012733" ; a owl:Class ; rdfs:label "Macule" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0012734 obo:IAO_0000115 "Low blood glucose is accompanied by elevated levels of ketone bodies in the body." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T03:00:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:20825002", "UMLS:C0271713" ; oboInOwl:hasExactSynonym "Ketotic low blood sugar" ; oboInOwl:id "HP:0012734" ; a owl:Class ; rdfs:label "Ketotic hypoglycemia" ; rdfs:subClassOf obo:HP_0001943 . obo:HP_0012735 obo:IAO_0000115 "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T03:19:50Z" ; oboInOwl:hasDbXref "MSH:D003371", "SNOMEDCT_US:263731006", "SNOMEDCT_US:272039006", "SNOMEDCT_US:49727002", "UMLS:C0010200" ; oboInOwl:hasExactSynonym "Cough", "Coughing" ; oboInOwl:id "HP:0012735" ; a owl:Class ; rdfs:comment "The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory manoeuvre, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). In adults, an acute cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks. In children aged less than 15 years a chronic cough is defined as a daily cough lasting for over 4 weeks." ; rdfs:label "Cough" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0012736 obo:IAO_0000115 "A profound delay in the achievement of motor or mental milestones in the domains of development of a child." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T03:21:25Z" ; oboInOwl:hasDbXref "UMLS:C1855773", "UMLS:C3553450" ; oboInOwl:hasExactSynonym "Global developmental delay, profound" ; oboInOwl:hasRelatedSynonym "Psychomotor retardation, profound" ; oboInOwl:id "HP:0012736" ; a owl:Class ; rdfs:label "Profound global developmental delay" ; rdfs:subClassOf obo:HP_0001263 . obo:HP_0012737 obo:IAO_0000115 "A discrete abnormal tissue mass that protrudes into the lumen of the small intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T03:50:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:399723004", "UMLS:C1302645" ; oboInOwl:id "HP:0012737" ; a owl:Class ; rdfs:label "Small intestinal polyp" ; rdfs:subClassOf obo:HP_0005266, obo:HP_0100833 . obo:HP_0012738 obo:IAO_0000115 "Agenesis of canine tooth." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T04:26:04Z" ; oboInOwl:hasDbXref "UMLS:C4021072", "UMLS:C4280311" ; oboInOwl:hasExactSynonym "Absent canines", "Failure of development of canine", "Failure of development of eye tooth" ; oboInOwl:hasRelatedSynonym "Absence of canine", "Absence of eye tooth", "Missing canine", "Missing eye tooth" ; oboInOwl:id "HP:0012738" ; a owl:Class ; rdfs:label "Agenesis of canine" ; rdfs:subClassOf obo:HP_0001592, obo:HP_0011078 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003674 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012739 obo:IAO_0000115 "Failure to develop of the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T04:28:53Z" ; oboInOwl:hasDbXref "UMLS:C4021071" ; oboInOwl:hasExactSynonym "Small bowel agenesis", "Undeveloped small intestine" ; oboInOwl:id "HP:0012739" ; a owl:Class ; rdfs:label "Agenesis of the small intestine" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0012740 obo:IAO_0000115 "A tumor of the skin or mucous membrane with finger-like projections." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T04:36:41Z" ; oboInOwl:hasDbXref "MSH:D010212", "SNOMEDCT_US:23730008", "SNOMEDCT_US:711329002", "UMLS:C0030354" ; oboInOwl:id "HP:0012740" ; a owl:Class ; rdfs:comment "The vast majority of papillomas are benign. Papillomas on the skin (cutaneous papillomas) are commonly referred to as warts." ; rdfs:label "Papilloma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0012741 obo:IAO_0000115 "Absence of a testis from the scrotum on one side owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T04:41:57Z" ; oboInOwl:hasDbXref "MSH:D003456", "SNOMEDCT_US:268227001", "UMLS:C0431664" ; oboInOwl:hasExactSynonym "Cryptorchidism, unilateral" ; oboInOwl:id "HP:0012741" ; a owl:Class ; rdfs:label "Unilateral cryptorchidism" ; rdfs:subClassOf obo:HP_0000028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0000028 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000634 ] ) ] ] . obo:HP_0012742 obo:IAO_0000115 "Fingernail that appears thin when viewed on end." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T04:47:40Z" ; oboInOwl:hasAlternativeId "HP:0040037" ; oboInOwl:hasDbXref "UMLS:C4022750" ; oboInOwl:hasExactSynonym "Thin fingernail" ; oboInOwl:id "HP:0012742" ; a owl:Class ; rdfs:comment "No objective standard for nail thickness could be identified. An unsupported claim suggests that nails are 0.5 mm in females and 0.6 mm in males (http://www.emedicine.com/orthoped/topic421.htm). Thin nails are usually brittle, may easily fray, or break at the free edge. Thin nails usually grow slowly but this definition does not require slow growth of the nail. Note that the term koilonychia is an abnormal shape of the fingernail where the nail has raised ridges and is thin and concave. Since it include other characteristics besides thin nails, it should not be used to indicate this. The affected digits should be specified." ; rdfs:label "Thin fingernail" ; rdfs:subClassOf obo:HP_0001231, obo:HP_0001816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012743 obo:IAO_0000115 "Excessive fat around the stomach and abdomen." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T05:00:05Z" ; oboInOwl:hasDbXref "MSH:D056128", "SNOMEDCT_US:248311001", "UMLS:C0311277" ; oboInOwl:hasExactSynonym "Abdominal obesity", "Central obesity" ; oboInOwl:id "HP:0012743" ; a owl:Class ; rdfs:label "Abdominal obesity" ; rdfs:subClassOf obo:HP_0001513 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001563 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001869 ] ) ] ] . obo:HP_0012744 obo:IAO_0000115 "Failure of the femur to develop." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T05:14:34Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:47276000", "UMLS:C0265629" ; oboInOwl:hasExactSynonym "Absent femur", "Absent thighbone", "Aplasia of the femur" ; oboInOwl:id "HP:0012744" ; a owl:Class ; rdfs:label "Femoral aplasia" ; rdfs:subClassOf obo:HP_0005613 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012745 obo:IAO_0000115 "Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T05:27:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:246802000", "UMLS:C0423112" ; oboInOwl:hasExactSynonym "Decreased height of palpebral fissure", "Short opening between the eyelids", "Short palpebral fissures" ; oboInOwl:id "HP:0012745" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short palpebral fissure" ; rdfs:subClassOf obo:HP_0200007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012746 obo:IAO_0000115 "Toenail that appears thin when viewed on end." ; dcterms:creator ; oboInOwl:creation_date "2014-03-23T05:34:43Z" ; oboInOwl:hasAlternativeId "HP:0040038" ; oboInOwl:hasDbXref "UMLS:C3554113" ; oboInOwl:hasExactSynonym "Thin toenail" ; oboInOwl:hasRelatedSynonym "Thin toenails" ; oboInOwl:id "HP:0012746" ; a owl:Class ; rdfs:comment "No objective standard for nail thickness could be identified. An unsupported claim suggests that nails are 0.5 mm in females and 0.6 mm in males (http://www.emedicine.com/orthoped/topic421.htm). Thin nails are usually brittle, may easily fray, or break at the free edge. Thin nails usually grow slowly but this definition does not require slow growth of the nail. Note that the term koilonychia is an abnormal shape of the fingernail where the nail has raised ridges and is thin and concave. Since it include other characteristics besides thin nails, it should not be used to indicate this. The affected digits should be specified." ; rdfs:label "Thin toenail" ; rdfs:subClassOf obo:HP_0001816, obo:HP_0008388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012747 obo:IAO_0000115 "A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:41:13Z" ; oboInOwl:hasDbXref "UMLS:C4022749" ; oboInOwl:id "HP:0012747" ; a owl:Class ; rdfs:label "Abnormal brainstem MRI signal intensity" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0012748 obo:IAO_0000115 "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:43:06Z" ; oboInOwl:hasDbXref "UMLS:C4022748" ; oboInOwl:id "HP:0012748" ; a owl:Class ; rdfs:label "Focal T2 hyperintense brainstem lesion" ; rdfs:subClassOf obo:HP_0012747 . obo:HP_0012749 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hypointensity affecting a particular region of the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:43:56Z" ; oboInOwl:hasDbXref "UMLS:C4022747" ; oboInOwl:id "HP:0012749" ; a owl:Class ; rdfs:label "Focal T2 hypointense brainstem lesion" ; rdfs:subClassOf obo:HP_0012747 . obo:HP_0012750 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a diffuse hypointensity affecting the entire brainstem." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:44:29Z" ; oboInOwl:hasDbXref "UMLS:C4022746" ; oboInOwl:id "HP:0012750" ; a owl:Class ; rdfs:label "T2 hypointense brainstem" ; rdfs:subClassOf obo:HP_0012747 . obo:HP_0012751 obo:IAO_0000115 "A deviation from normal signal on magnetic resonance imaging (MRI) of the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:47:28Z" ; oboInOwl:hasDbXref "UMLS:C4022745" ; oboInOwl:id "HP:0012751" ; a owl:Class ; rdfs:label "Abnormal basal ganglia MRI signal intensity" ; rdfs:subClassOf obo:HP_0002134 . obo:HP_0012752 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hypointensity affecting a particular region of the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:52:14Z" ; oboInOwl:hasDbXref "UMLS:C4022744" ; oboInOwl:id "HP:0012752" ; a owl:Class ; rdfs:label "Focal T2 hypointense basal ganglia lesion" ; rdfs:subClassOf obo:HP_0012751 . obo:HP_0012753 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a diffuse hypointensity affecting all of the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T06:52:42Z" ; oboInOwl:hasDbXref "UMLS:C4022743" ; oboInOwl:id "HP:0012753" ; a owl:Class ; rdfs:label "T2 hypointense basal ganglia" ; rdfs:subClassOf obo:HP_0012751 . obo:HP_0012754 obo:IAO_0000115 "Increased amount of myelin in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T07:15:56Z" ; oboInOwl:hasDbXref "UMLS:C4022742" ; oboInOwl:id "HP:0012754" ; a owl:Class ; rdfs:label "CNS hypermyelination" ; rdfs:subClassOf obo:HP_0011400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000345 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012755 obo:IAO_0000115 "Abnormal increase in size of the brainstem." ; dcterms:creator ; oboInOwl:creation_date "2014-03-30T07:23:06Z" ; oboInOwl:hasDbXref "UMLS:C4022741" ; oboInOwl:id "HP:0012755" ; a owl:Class ; rdfs:comment "An enlarged brainstem may be observed with diffuse infiltrating tumor, PNET (primitive neuroectodermal tumor), ganglionoma, hamartoma, vascular malformation, or inflammatory process." ; rdfs:label "Enlarged brainstem" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0012756 obo:IAO_0000115 "An increased polymorphonuclear cell count in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2014-04-02T01:07:51Z" ; oboInOwl:hasDbXref "UMLS:C4022740" ; oboInOwl:id "HP:0012756" ; a owl:Class ; rdfs:label "CSF polymorphonuclear pleocytosis" ; rdfs:subClassOf obo:HP_0012229 . obo:HP_0012757 obo:IAO_0000115 "A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions." ; dcterms:creator ; oboInOwl:creation_date "2014-04-02T05:12:30Z" ; oboInOwl:hasDbXref "UMLS:C4022739" ; oboInOwl:hasExactSynonym "Abnormal neuron shape", "Abnormal neuronal morphology" ; oboInOwl:id "HP:0012757" ; a owl:Class ; rdfs:label "Abnormal neuron morphology" ; rdfs:subClassOf obo:HP_0012639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000540 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012758 obo:IAO_0000115 "Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems." ; dcterms:creator ; oboInOwl:creation_date "2014-04-03T12:16:19Z" ; oboInOwl:hasDbXref "UMLS:C4022738" ; oboInOwl:hasExactSynonym "NDD" ; oboInOwl:id "HP:0012758" ; a owl:Class ; rdfs:comment "Though the definitions of NDD vary broadly in the literature, all are used to signify a delay in one or more developmental domains compared to typical development." ; rdfs:label "Neurodevelopmental delay" ; rdfs:subClassOf obo:HP_0012759 . obo:HP_0012759 obo:IAO_0000115 "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities." ; dcterms:creator ; oboInOwl:creation_date "2014-04-03T12:20:28Z" ; oboInOwl:hasDbXref "UMLS:C4022737" ; oboInOwl:id "HP:0012759" ; a owl:Class ; rdfs:comment "This term should be used to describe abnormalities with onset in the developmental period." ; rdfs:label "Neurodevelopmental abnormality" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0012760 obo:IAO_0000115 "A reduced ability to participate in the back-and-forth flow of social interaction appropriate to culture and developmental level, which is normally characterized by an influence of the behavior of one person on the behavior of another person." ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:creation_date "2014-04-03T12:52:44Z" ; oboInOwl:hasDbXref "UMLS:C4022736" ; oboInOwl:hasExactSynonym "Impaired social reciprocity" ; oboInOwl:id "HP:0012760" ; a owl:Class ; rdfs:label "Reduced social reciprocity" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_0012761 obo:IAO_0000115 "A developmental anomaly in which the mastoid process fails to form and is thus found to be congenitally absent." ; dcterms:creator ; oboInOwl:creation_date "2014-04-03T01:06:18Z" ; oboInOwl:hasAlternativeId "HP:0200110" ; oboInOwl:hasDbXref "UMLS:C4021070" ; oboInOwl:hasExactSynonym "Absent mastoids", "Failure of development of mastoid", "Mastoid agenesis" ; oboInOwl:id "HP:0012761" ; a owl:Class ; rdfs:label "Absent mastoid" ; rdfs:subClassOf obo:HP_0000264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011220 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012762 obo:IAO_0000115 "The presence of atrophy (wasting) of the cerebral white matter." ; dcterms:creator ; oboInOwl:creation_date "2014-04-06T10:55:36Z" ; oboInOwl:hasDbXref "UMLS:C4022735" ; oboInOwl:id "HP:0012762" ; a owl:Class ; rdfs:label "Cerebral white matter atrophy" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012763 obo:IAO_0000115 "A sudden attack of dyspnea that occurs while the affected person is at rest." ; dcterms:creator ; oboInOwl:creation_date "2014-04-06T10:58:39Z" ; oboInOwl:hasDbXref "MSH:D004418", "SNOMEDCT_US:59265000", "UMLS:C0013405" ; oboInOwl:hasExactSynonym "Paroxysmal dyspnoea" ; oboInOwl:id "HP:0012763" ; a owl:Class ; rdfs:comment "Paroxysmal nocturnal dyspnea (PND) is a sensation of shortness of breath that awakens the patient, often after 1 or 2 hours of sleep, and is usually relieved in the upright position." ; rdfs:label "Paroxysmal dyspnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0012764 obo:IAO_0000115 "A sensation of breathlessness in the recumbent position, relieved by sitting or standing." ; dcterms:creator ; oboInOwl:creation_date "2014-04-06T11:03:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:62744007", "UMLS:C0085619" ; oboInOwl:id "HP:0012764" ; a owl:Class ; rdfs:label "Orthopnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0012765 obo:IAO_0000115 "An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2014-04-06T11:06:46Z" ; oboInOwl:hasDbXref "UMLS:C4022734" ; oboInOwl:id "HP:0012765" ; a owl:Class ; rdfs:label "Widened cerebellar subarachnoid space" ; rdfs:subClassOf obo:HP_0012704 . obo:HP_0012766 obo:IAO_0000115 "An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebrum." ; dcterms:creator ; oboInOwl:creation_date "2014-04-06T11:08:12Z" ; oboInOwl:hasDbXref "UMLS:C4022733" ; oboInOwl:id "HP:0012766" ; a owl:Class ; rdfs:label "Widened cerebral subarachnoid space" ; rdfs:subClassOf obo:HP_0012704 . obo:HP_0012767 obo:IAO_0000115 "A deviation from normal size of the placenta." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T12:11:29Z" ; oboInOwl:hasDbXref "UMLS:C4022732" ; oboInOwl:id "HP:0012767" ; a owl:Class ; rdfs:label "Abnormal placental size" ; rdfs:subClassOf obo:HP_0100767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012768 obo:IAO_0000115 "Respiratory failure in the newborn." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T12:39:08Z" ; oboInOwl:hasDbXref "MSH:D001238", "SNOMEDCT_US:28314004", "SNOMEDCT_US:413654009", "UMLS:C0004045" ; oboInOwl:hasExactSynonym "Asphyxia neonatorum" ; oboInOwl:id "HP:0012768" ; a owl:Class ; rdfs:label "Neonatal asphyxia" ; rdfs:subClassOf obo:HP_0002643 . obo:HP_0012769 obo:IAO_0000115 "A deviation from normal of the length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)" ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:09:08Z" ; oboInOwl:hasDbXref "UMLS:C4022731" ; oboInOwl:hasExactSynonym "Abnormal arm span" ; oboInOwl:id "HP:0012769" ; a owl:Class ; rdfs:label "Abnormal arm span" ; rdfs:subClassOf obo:HP_0002817 . obo:HP_0012770 obo:IAO_0000115 "Decreased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:09:58Z" ; oboInOwl:hasDbXref "UMLS:C4022730" ; oboInOwl:hasExactSynonym "Reduced arm span" ; oboInOwl:id "HP:0012770" ; a owl:Class ; rdfs:label "Reduced arm span" ; rdfs:subClassOf obo:HP_0012769 . obo:HP_0012771 obo:IAO_0000115 "Increased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:10:35Z" ; oboInOwl:hasDbXref "UMLS:C4022729" ; oboInOwl:hasExactSynonym "Increased arm span" ; oboInOwl:id "HP:0012771" ; a owl:Class ; rdfs:label "Increased arm span" ; rdfs:subClassOf obo:HP_0012769 . obo:HP_0012772 obo:IAO_0000115 "A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:12:56Z" ; oboInOwl:hasDbXref "UMLS:C4022728" ; oboInOwl:id "HP:0012772" ; a owl:Class ; rdfs:label "Abnormal upper to lower segment ratio" ; rdfs:subClassOf obo:HP_0000002 . obo:HP_0012773 obo:IAO_0000115 "Decreased ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis. Consider the term Disproportionate tall stature (HP:0001519) if tall stature is also present." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:14:28Z" ; oboInOwl:hasDbXref "UMLS:C1836996" ; oboInOwl:id "HP:0012773" ; a owl:Class ; rdfs:comment "A ratio of less than 0.86 (or according to other sources 0.89) is considered abnormally reduced." ; rdfs:label "Reduced upper to lower segment ratio" ; rdfs:subClassOf obo:HP_0012772 . obo:HP_0012774 obo:IAO_0000115 "Elevated ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:16:21Z" ; oboInOwl:hasDbXref "UMLS:C1844571" ; oboInOwl:id "HP:0012774" ; a owl:Class ; rdfs:label "Increased upper to lower segment ratio" ; rdfs:subClassOf obo:HP_0012772 . obo:HP_0012775 obo:IAO_0000115 "A lacy pattern or iris pigmentation that resembles the spokes of a bicycle wheel." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T03:54:41Z" ; oboInOwl:hasDbXref "UMLS:C4022727" ; oboInOwl:id "HP:0012775" ; a owl:Class ; rdfs:label "Stellate iris" ; rdfs:subClassOf obo:HP_0008034 . obo:HP_0012776 obo:IAO_0000115 "A structural anomaly of the ciliary body." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T04:00:10Z" ; oboInOwl:hasDbXref "UMLS:C4022726" ; oboInOwl:hasExactSynonym "Abnormality of the ciliary body" ; oboInOwl:id "HP:0012776" ; a owl:Class ; rdfs:label "Abnormal ciliary body morphology" ; rdfs:subClassOf obo:HP_0000553 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012777 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the retina." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T05:38:24Z" ; oboInOwl:hasDbXref "MSH:D019572", "NCIT:C3262", "SNOMEDCT_US:127002001", "UMLS:C0524801" ; oboInOwl:id "HP:0012777" ; a owl:Class ; rdfs:label "Retinal neoplasm" ; rdfs:subClassOf obo:HP_0000479, obo:HP_0100012 . obo:HP_0012778 obo:IAO_0000115 "A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T05:38:54Z" ; oboInOwl:hasDbXref "UMLS:C4022725" ; oboInOwl:id "HP:0012778" ; a owl:Class ; rdfs:comment "Classically retinal astrocytic hamartomas appear as a cream-white, well-circumscribed, elevated lesions that may present as multiple or solitary sites. A lesion is commonly seen with a multilobulated, \"mulberry\" appearance, but can also appear flat and semitranslucent. It is most frequently associated with tuberous sclerosis but may also be found rarely in patients with neurofibromatosis. Although the finding may point toward a systemic association, it can also be found incidentally on retinal examination as an isolated presentation." ; rdfs:label "Retinal astrocytic hamartoma" ; rdfs:subClassOf obo:HP_0009594 . obo:HP_0012779 obo:IAO_0000115 "Hearing loss that occurs acutely and resolves completely." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T06:09:19Z" ; oboInOwl:hasDbXref "UMLS:C4022724" ; oboInOwl:id "HP:0012779" ; a owl:Class ; rdfs:comment "Transient hearing loss is particularly common in childhood as a result of inadequate ventilation of the middle ear." ; rdfs:label "Transient hearing impairment" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012780 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the ear." ; dcterms:creator ; oboInOwl:creation_date "2014-04-07T06:11:56Z" ; oboInOwl:hasDbXref "MSH:D004428", "NCIT:C3262", "SNOMEDCT_US:363228008", "UMLS:C0013449" ; oboInOwl:hasExactSynonym "Ear tumor", "Ear tumour" ; oboInOwl:id "HP:0012780" ; a owl:Class ; rdfs:label "Neoplasm of the ear" ; rdfs:subClassOf obo:HP_0011793, obo:HP_0031703 . obo:HP_0012781 obo:IAO_0000115 "A type of hearing impairment affecting primarily the middle frequencies of sound (1000 Hz to 3000 Hz)." ; dcterms:creator ; oboInOwl:creation_date "2014-04-08T11:04:07Z" ; oboInOwl:hasDbXref "UMLS:C4022723" ; oboInOwl:id "HP:0012781" ; a owl:Class ; rdfs:label "Mid-frequency hearing loss" ; rdfs:subClassOf obo:HP_0000365 . obo:HP_0012782 obo:IAO_0000115 "A type of nephrogenic rest associated with multiple lesions in the periphery of the renal lobe." ; dcterms:creator ; oboInOwl:creation_date "2014-04-20T03:23:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:405935000", "UMLS:C1319017" ; oboInOwl:hasExactSynonym "Perilobar nephrogenic rests" ; oboInOwl:id "HP:0012782" ; a owl:Class ; rdfs:comment "Perilobar nephrogenic rests are associated with Beckwith-Wiedemann syndrome (BWS) and hemi-hyperplasia." ; rdfs:label "Perilobar nephrogenic rest" ; rdfs:subClassOf obo:HP_0100880 . obo:HP_0012783 obo:IAO_0000115 "A type of nephrogenic rest usually representing single lesions within the renal lobe, renal sinus, or calyceal walls." ; dcterms:creator ; oboInOwl:creation_date "2014-04-20T03:24:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:405934001", "UMLS:C1319016" ; oboInOwl:hasExactSynonym "Intralobar nephrogenic rests" ; oboInOwl:id "HP:0012783" ; a owl:Class ; rdfs:comment "Intralobar nephrogenic rests are associated WAGR (Wilms tumor-aniridia-genital anomalies-retardation) syndrome and Denys-Drash syndrome (DDS)." ; rdfs:label "Intralobar nephrogenic rest" ; rdfs:subClassOf obo:HP_0100880 . obo:HP_0012784 obo:IAO_0000115 "Inflammation of the connective and adipose tissues surrounding the kidney." ; dcterms:creator ; oboInOwl:creation_date "2014-04-20T03:32:07Z" ; oboInOwl:hasDbXref "MSH:D010501", "SNOMEDCT_US:111404004", "UMLS:C0031065" ; oboInOwl:id "HP:0012784" ; a owl:Class ; rdfs:label "Perinephritis" ; rdfs:subClassOf obo:HP_0000123 . obo:HP_0012785 obo:IAO_0000115 "Chronic loss of joint motion in a finger due to structural changes in non-bony tissue." ; dcterms:creator ; oboInOwl:creation_date "2014-04-20T04:09:34Z" ; oboInOwl:hasDbXref "UMLS:C1857304" ; oboInOwl:hasExactSynonym "Flexion deformity of finger" ; oboInOwl:id "HP:0012785" ; a owl:Class ; rdfs:comment "Note that the term camptodactyly refers to a painless flexion contracture of the proximal interphalangeal (PIP) joint and not to a finger joint contracture in general." ; rdfs:label "Flexion contracture of finger" ; rdfs:subClassOf obo:HP_0034681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012786 obo:IAO_0000115 "Repeated infections of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2014-04-22T09:18:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:197853008", "UMLS:C0581366" ; oboInOwl:hasExactSynonym "Recurrent bladder infections" ; oboInOwl:id "HP:0012786" ; a owl:Class ; rdfs:comment "One definition of recurrent cystitis involves 3 or more diagnosed cystitis episodes (ICD-9 codes 595.0, 595.9, 597.81, 599.0 with episodes separated by 30 days or more) within a 12-month period or 2 episodes within 6 months." ; rdfs:label "Recurrent cystitis" ; rdfs:subClassOf obo:HP_0000010 . obo:HP_0012787 obo:IAO_0000115 "Repeated episodes of pyelonephritis." ; dcterms:creator ; oboInOwl:creation_date "2014-04-22T09:24:10Z" ; oboInOwl:hasDbXref "UMLS:C0748199" ; oboInOwl:id "HP:0012787" ; a owl:Class ; rdfs:label "Recurrent pyelonephritis" ; rdfs:subClassOf obo:HP_0000010, obo:HP_0012330 . obo:HP_0012788 obo:IAO_0000115 "A net-like pattern of increased pigmentation of the oral cavity." ; dcterms:creator ; oboInOwl:creation_date "2014-04-22T09:31:07Z" ; oboInOwl:hasDbXref "UMLS:C1852148" ; oboInOwl:hasExactSynonym "Mottled pigmentation of oral mucosa", "Reticulate pigmentation of oral mucous membrane" ; oboInOwl:id "HP:0012788" ; a owl:Class ; rdfs:label "Reticulate pigmentation of oral mucosa" ; rdfs:subClassOf obo:HP_0100669 . obo:HP_0012789 obo:IAO_0000115 "Underdevelopment of the heel bone." ; dcterms:creator ; oboInOwl:creation_date "2014-04-22T09:58:48Z" ; oboInOwl:hasDbXref "UMLS:C3550873" ; oboInOwl:hasExactSynonym "Hypoplastic calcaneus", "Small heel bone", "Underdeveloped heel bone" ; oboInOwl:id "HP:0012789" ; a owl:Class ; rdfs:label "Hypoplasia of the calcaneus" ; rdfs:subClassOf obo:HP_0008363, obo:HP_0008364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012790 obo:IAO_0000115 "An anomaly in the process of intramembranous ossification by which flat bones (cranial bones of the skull, i.e., the frontal, parietal, occipital, and temporal bones, and the clavicles) are formed." ; dcterms:creator ; oboInOwl:creation_date "2014-04-24T10:18:31Z" ; oboInOwl:hasDbXref "UMLS:C4021069" ; oboInOwl:hasExactSynonym "Abnormal intramembranous bone ossification" ; oboInOwl:id "HP:0012790" ; a owl:Class ; rdfs:label "Abnormal intramembranous ossification" ; rdfs:subClassOf obo:HP_0011849 . obo:HP_0012791 obo:IAO_0000115 "An anomaly of the process of formation of bone in the humerus." ; dcterms:creator ; oboInOwl:creation_date "2014-04-24T10:23:43Z" ; oboInOwl:hasDbXref "UMLS:C4022722" ; oboInOwl:hasExactSynonym "Abnormal maturation of long bone in upper arm" ; oboInOwl:id "HP:0012791" ; a owl:Class ; rdfs:label "Abnormal humeral ossification" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0003336 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf _:genid86692 ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012792 obo:IAO_0000115 "A lack of bone mineralization of one or more body of thoracic vertebra." ; dcterms:creator ; oboInOwl:creation_date "2014-04-24T11:05:14Z" ; oboInOwl:hasDbXref "UMLS:C4022721" ; oboInOwl:id "HP:0012792" ; a owl:Class ; rdfs:label "Absent ossification of thoracic vertebral bodies" ; rdfs:subClassOf obo:HP_0004599 ; owl:equivalentClass _:genid86692 . obo:HP_0012793 obo:IAO_0000115 "A kinked appearance of the brainstem, i.e., an exaggerated flexure." ; dcterms:creator ; oboInOwl:creation_date "2014-04-25T02:51:49Z" ; oboInOwl:hasDbXref "UMLS:C4021068" ; oboInOwl:hasExactSynonym "Kinked brain stem" ; oboInOwl:id "HP:0012793" ; a owl:Class ; rdfs:comment "Kinked brainstem is an indicator of severe neurodysgenesis arising early in gestation. This sign can be appreciated in prenatal magnetic resonance imaging." ; rdfs:label "Kinked brainstem" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0012794 obo:IAO_0000115 "Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles." ; dcterms:creator ; oboInOwl:creation_date "2014-04-25T03:00:01Z" ; oboInOwl:hasDbXref "UMLS:C4022720" ; oboInOwl:hasExactSynonym "Periventricular cerebral white matter hypodensities" ; oboInOwl:id "HP:0012794" ; a owl:Class ; rdfs:comment "See also defintion for \"Deep white matter hypodensities\". These two entities are in contra-distinction to each other." ; rdfs:label "Periventricular white matter hypodensities" ; rdfs:subClassOf obo:HP_0007103 . obo:HP_0012795 obo:IAO_0000115 "A morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination." ; dcterms:creator ; oboInOwl:creation_date "2014-05-24T04:37:10Z" ; oboInOwl:hasDbXref "UMLS:C3808249" ; oboInOwl:id "HP:0012795" ; a owl:Class ; rdfs:comment "The term 'optic disc' is frequently used to describe the portion of the optic nerve clinically visible on fundoscopic examination." ; rdfs:label "Abnormal optic disc morphology" ; rdfs:subClassOf obo:HP_0000587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001783 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012796 obo:IAO_0000115 "An elevation in the ratio of the diameter of the cup of the optic disc to the total diameter of the disc. The optic disc has an orange-pink rim with a pale centre (the cup) that does not contain neuroretinal tissue. An increase in this ratio therefore may indicate a decrease in the quantity of healthy neuroretinal cells." ; dcterms:creator ; oboInOwl:creation_date "2014-05-24T04:43:52Z" ; oboInOwl:hasDbXref "UMLS:C3805911" ; oboInOwl:hasExactSynonym "Elevated cup to disc ratio", "Increased cup disc ratio" ; oboInOwl:id "HP:0012796" ; a owl:Class ; rdfs:comment "A cup to disc ratio of 0.3 is generally considered normal. Note that the ratio is measured in the vertical orientation unless otherwise specified." ; rdfs:label "Increased cup-to-disc ratio" ; rdfs:subClassOf obo:HP_0012795 . obo:HP_0012797 obo:IAO_0000115 "A benign or malignant neoplasm arising from the lymphatic vessels." ; dcterms:creator ; oboInOwl:creation_date "2014-05-24T05:00:34Z" ; oboInOwl:hasDbXref "MSH:D018190", "NCIT:C3262", "SNOMEDCT_US:115236002", "UMLS:C0206619" ; oboInOwl:hasExactSynonym "Lymphatic vessel tumor", "Lymphatic vessel tumour" ; oboInOwl:id "HP:0012797" ; a owl:Class ; rdfs:label "Lymphatic vessel neoplasm" ; rdfs:subClassOf obo:HP_0100742, obo:HP_0100766 . obo:HP_0012798 obo:IAO_0000115 "Infiltration of smooth muscle-like cells in lymph vessels as well as the lung (pleura, alveolar septa, bronchi, pulmonary vessels and lymphatics as well as lymph nodes, especially in posterior mediastinum and retroperitoneum). Focal emphysema can develop because of airway narrowing, and the thoracic duct may be obliterated. Pulmonary lymphangiomyomatosis may lead to multiple small cysts with a hamartomatous proliferation of smooth muscle in their walls." ; dcterms:creator ; oboInOwl:creation_date "2014-05-24T05:00:46Z" ; oboInOwl:hasDbXref "MSH:D018192", "SNOMEDCT_US:73017001", "UMLS:C0238399", "UMLS:C0751674" ; oboInOwl:hasExactSynonym "Pulmonary myomatosis" ; oboInOwl:hasRelatedSynonym "Lymphangioleiomyomatosis" ; oboInOwl:id "HP:0012798" ; a owl:Class ; rdfs:comment "Pulmonary lymphangiomyomatosis is a manifestation of lymphangioleiomyomatosis, which may also affect extrapulmonary locations. It can be seen in tuberous sclerosis." ; rdfs:label "Pulmonary lymphangiomyomatosis" ; rdfs:subClassOf obo:HP_0012797, obo:HP_0100526 . obo:HP_0012799 obo:IAO_0000115 "One-sided weakness of the muscles of facial expression and eye closure." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T10:35:53Z" ; oboInOwl:hasDbXref "UMLS:C0239516", "UMLS:C4022719" ; oboInOwl:hasExactSynonym "Facial droop", "Paralysis of one side of the face", "Unilateral facial muscle paralysis", "Unilateral facial muscle weakness", "Unilateral facial paralysis", "Unilateral facial weakness", "Weakness of one side of the face" ; oboInOwl:id "HP:0012799" ; a owl:Class ; rdfs:label "Unilateral facial palsy" ; rdfs:subClassOf obo:HP_0010628 . obo:HP_0012800 obo:IAO_0000115 "A cranial suture that is in addition to canonical membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T10:54:52Z" ; oboInOwl:hasDbXref "UMLS:C4021067", "UMLS:C4022927" ; oboInOwl:hasExactSynonym "Extra cranial suture", "Supernumary cranial suture" ; oboInOwl:hasNarrowSynonym "Accessory fontanelle", "Extra fontanelle", "Supernumary fontanelle" ; oboInOwl:id "HP:0012800" ; a owl:Class ; rdfs:comment "The parietal and occipital bones in particular are common regions for accessory sutures because of their multiple ossification centers. Accessory sutures can be explained on the basis of incomplete union of the two separate ossification centers. Accessory sutures usually will show a zigzag pattern with interdigitations and sclerotic borders similar to major calvarial sutures." ; rdfs:label "Accessory cranial suture" ; rdfs:subClassOf obo:HP_0011329 . obo:HP_0012801 obo:IAO_0000115 "Bigonial distance (lower facial width) more than 2 standard deviations below the mean (objective); or an apparently decreased width of the lower jaw (mandible) when viewed from the front (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T02:37:13Z" ; oboInOwl:hasDbXref "UMLS:C4021066", "UMLS:C4280310" ; oboInOwl:hasExactSynonym "Narrow jaw", "Narrow lower face", "Narrow lower jaw", "Narrow mandible" ; oboInOwl:hasRelatedSynonym "Thin lower face", "Thin lower jaw" ; oboInOwl:id "HP:0012801" ; a owl:Class ; rdfs:comment "The width of the jaw is measured from the right gonion to the left gonion using spreading calipers. The gonion is the point at the angle of the bony mandible where the ramus changes direction to become the body of the mandible. It faces inferiorly and medially and is best found by placing a finger over the outward facing angle and rolling the finger downwards and inwards." ; rdfs:label "Narrow jaw" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012802 obo:IAO_0000115 "Bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective)." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T02:41:43Z" ; oboInOwl:hasDbXref "UMLS:C3281059" ; oboInOwl:hasExactSynonym "Broad jaw", "Broad lower face", "Broad mandible", "Wide jaw", "Wide mandible" ; oboInOwl:id "HP:0012802" ; a owl:Class ; rdfs:comment "The lower jaw is measured from the right gonion to the left gonion using spreading calipers. The gonion is the point at the angle of the bony mandible where the ramus changes direction to become the body of the mandible. It faces inferiorly and medially and is best found by placing a finger over the outward facing angle and rolling the finger downwards and inwards. When a broad jaw is accompanied by a broad upper face the term Square face is used." ; rdfs:label "Broad jaw" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012803 obo:IAO_0000115 "Inequality of refractive power of the two eyes." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T03:05:21Z" ; oboInOwl:hasDbXref "MSH:D015858", "SNOMEDCT_US:3289004", "UMLS:C0003081" ; oboInOwl:id "HP:0012803" ; a owl:Class ; rdfs:label "Anisometropia" ; rdfs:subClassOf obo:HP_0000539 . obo:HP_0012804 obo:IAO_0000115 "Disruption of the epithelial layer of the cornea with involvement of the underlying stroma." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T03:25:51Z" ; oboInOwl:hasDbXref "MSH:D003320", "SNOMEDCT_US:91514001", "UMLS:C0010043" ; oboInOwl:hasExactSynonym "Corneal ulcer", "Corneal ulcerations" ; oboInOwl:id "HP:0012804" ; a owl:Class ; rdfs:label "Corneal ulceration" ; rdfs:subClassOf obo:HP_0011495 . obo:HP_0012805 obo:IAO_0000115 "Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T03:43:06Z" ; oboInOwl:hasDbXref "UMLS:C1096099" ; oboInOwl:id "HP:0012805" ; a owl:Class ; rdfs:comment "Initially, transillumination defects are usually slit-like, but if pigment loss increases, the defects may be become larger and irregularly shaped." ; rdfs:label "Iris transillumination defect" ; rdfs:subClassOf obo:HP_0008034 . obo:HP_0012806 obo:IAO_0000115 "A fleshy, tube-like structure usually located in the midline of the face or just to one side of the midline." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T05:46:42Z" ; oboInOwl:hasDbXref "UMLS:C0687082" ; oboInOwl:id "HP:0012806" ; a owl:Class ; rdfs:comment "A proboscis has a single cavity. It may be found in association with a malformed nose and absence of one or both nares." ; rdfs:label "Proboscis" ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0012807 obo:IAO_0000115 "Insertion of the posterior columella superior to the nasal base." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T05:51:17Z" ; oboInOwl:hasBroadSynonym "Ala lower than columella" ; oboInOwl:hasDbXref "UMLS:C4020909" ; oboInOwl:hasExactSynonym "Columella, high insertion" ; oboInOwl:id "HP:0012807" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature is different from a convex Low hanging columella that has a normal insertion. It may be associated with a Short philtrum, but this should be assessed and coded separately. A low insertion is best appreciated when viewed from the side." ; rdfs:label "High insertion of columella" ; rdfs:subClassOf obo:HP_0009929 . obo:HP_0012808 obo:IAO_0000115 "An anomaly of the nasal base, which can be conceived of as an imaginary line between the most lateral points of the external inferior attachments of the alae nasi to the face." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T05:56:47Z" ; oboInOwl:hasDbXref "UMLS:C4022718" ; oboInOwl:hasExactSynonym "Abnormal nasal base", "Abnormality of base of nose", "Anomaly of base of nose", "Anomaly of nasal base" ; oboInOwl:hasNarrowSynonym "Deformity of base of nose", "Deformity of nasal base", "Malformation of base of nose", "Malformation of nasal base" ; oboInOwl:id "HP:0012808" ; a owl:Class ; rdfs:label "Abnormal nasal base norphology" ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0012809 obo:IAO_0000115 "Decreased distance between the attachments of the alae nasi to the face." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T05:58:16Z" ; oboInOwl:hasDbXref "UMLS:C4022717" ; oboInOwl:hasExactSynonym "Decreased width of base of nose", "Decreased width of nasal base", "Narrow base of nose", "Narrow nasal base", "Thin base of nose", "Thin nasal base" ; oboInOwl:id "HP:0012809" ; a owl:Class ; rdfs:comment "There is a marked difference in width of the nasal base depending on ethnic background." ; rdfs:label "Narrow nasal base" ; rdfs:subClassOf obo:HP_0012808 . obo:HP_0012810 obo:IAO_0000115 "Increased distance between the attachments of the alae nasi to the face." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T05:59:12Z" ; oboInOwl:hasDbXref "UMLS:C1849667" ; oboInOwl:hasExactSynonym "Broad base of nose", "Broad nasal base", "Increased width of base of nose", "Increased width of nasal base", "Wide base of nose", "Wide nasal base" ; oboInOwl:id "HP:0012810" ; a owl:Class ; rdfs:comment "There is a marked difference in width of the nasal base depending on ethnic background." ; rdfs:label "Wide nasal base" ; rdfs:subClassOf obo:HP_0012808 . obo:HP_0012811 obo:IAO_0000115 "Increased width of the nasal ridge." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T10:38:03Z" ; oboInOwl:hasDbXref "UMLS:C4020718" ; oboInOwl:hasExactSynonym "Broad dorsum of nose", "Broad nasal dorsum", "Increased width of dorsum of nose", "Increased width of nasal dorsum", "Increased width of nasal ridge", "Nasal ridge, wide", "Wide dorsum of nose", "Wide nasal dorsum", "Wide nasal ridge" ; oboInOwl:hasRelatedSynonym "Broad nasal ridge" ; oboInOwl:id "HP:0012811" ; a owl:Class ; rdfs:comment "This feature should be assessed in a frontal view. There is no objective measure of width. This may give the impression of a Depressed nasal ridge, but this should be assessed in profile and separately coded. Marked widening of the nasal ridge may be difficult to distinguish from a Bifid nose." ; rdfs:label "Wide nasal ridge" ; rdfs:subClassOf obo:HP_0011119 . obo:HP_0012812 obo:IAO_0000115 "Increased bulk of tissue alongside the nose. The fullness can be caused by both bony and soft tissues." ; dcterms:creator ; oboInOwl:creation_date "2014-05-25T10:40:06Z" ; oboInOwl:hasDbXref "UMLS:C4021065", "UMLS:C4280308", "UMLS:C4280309" ; oboInOwl:hasExactSynonym "Fullness of tissue around the nose", "Laterally built up nose", "Paranasal fullness", "Thick paranasal tissue", "Thick tissue around the nose" ; oboInOwl:hasNarrowSynonym "Hyperplasia of paranasal tissue", "Hypertrophy of paranasal tissue" ; oboInOwl:id "HP:0012812" ; a owl:Class ; rdfs:comment "This feature is distinct from Wide nasal ridge and Wide nasal bridge." ; rdfs:label "Fullness of paranasal tissue" ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0012813 obo:IAO_0000115 "Underdevelopment of the breast on one side only." ; dcterms:creator ; oboInOwl:creation_date "2014-05-26T08:11:58Z" ; oboInOwl:hasDbXref "UMLS:C1844722" ; oboInOwl:hasExactSynonym "One underdeveloped breast" ; oboInOwl:id "HP:0012813" ; a owl:Class ; rdfs:label "Unilateral breast hypoplasia" ; rdfs:subClassOf obo:HP_0003187 . obo:HP_0012814 obo:IAO_0000115 "Underdevelopment of the breast on both sides." ; dcterms:creator ; oboInOwl:creation_date "2014-05-26T08:12:34Z" ; oboInOwl:hasDbXref "UMLS:C4022716" ; oboInOwl:hasExactSynonym "Two underdeveloped breasts" ; oboInOwl:id "HP:0012814" ; a owl:Class ; rdfs:label "Bilateral breast hypoplasia" ; rdfs:subClassOf obo:HP_0003187 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0012815 obo:IAO_0000115 "Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris)." ; dcterms:creator ; oboInOwl:creation_date "2014-05-27T08:14:55Z" ; oboInOwl:hasDbXref "UMLS:C4022715" ; oboInOwl:hasExactSynonym "Underdeveloped female external genitalia" ; oboInOwl:id "HP:0012815" ; a owl:Class ; rdfs:label "Hypoplastic female external genitalia" ; rdfs:subClassOf obo:HP_0000055, obo:HP_0003241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012816 obo:IAO_0000115 "A predominantly right ventricular variant of isolated noncompaction cardiomyopathy." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T08:35:01Z" ; oboInOwl:hasDbXref "UMLS:C4022714" ; oboInOwl:id "HP:0012816" ; a owl:Class ; rdfs:label "Right ventricular noncompaction cardiomyopathy" ; rdfs:subClassOf obo:HP_0012817 . obo:HP_0012817 obo:IAO_0000115 "A type of cardiomyopathy characterized anatomically by deep trabeculations in the ventricular wall, which define recesses communicating with the main ventricular chamber." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T08:37:34Z" ; oboInOwl:hasDbXref "UMLS:C1839832" ; oboInOwl:hasExactSynonym "Noncompaction of the ventricular myocardium", "Spongiform cardiomyopathy" ; oboInOwl:id "HP:0012817" ; a owl:Class ; rdfs:comment "Noncompaction of the ventricular myocardium is a cardiomyopathy thought to be caused by arrest of normal embryogenesis of the endocardium and myocardium. This abnormality is often associated with other congenital cardiac defects, but it is also seen in the absence of other cardiac anomalies. During early embryonic development, the myocardium is a loose network of interwoven fibers separated by deep recesses that link the myocardium with the left ventricular cavity. Gradual compaction of this spongy meshwork of fibers and intertrabecular recesses, or sinusoids, occurs between weeks 5 and 8 of embryonic life, proceeding from the epicardium to endocardium and from the base of the heart to the apex. Noncompaction of the ventricular myocardium (NVM) is an uncommon finding. It is thought to be caused by arrest of the normal process of endomyocardial morphogenesis. The left ventricle is uniformly affected, but biventricular noncompaction has been reported, with right ventricular noncompaction described in less than one-half of patients. Because of difficulty in distinguishing normal variants in the highly trabeculated right ventricle from the pathological noncompacted ventricle, several authors dispute the existence of right ventricular noncompaction [PMID:15210614]." ; rdfs:label "Noncompaction cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0012818 obo:IAO_0000115 "Noncompaction cardiomyopathy that affects both ventricles." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T08:49:23Z" ; oboInOwl:hasDbXref "UMLS:C4022713" ; oboInOwl:id "HP:0012818" ; a owl:Class ; rdfs:label "Biventricular noncompaction cardiomyopathy" ; rdfs:subClassOf obo:HP_0012817 . obo:HP_0012819 obo:IAO_0000115 "Inflammation of the myocardium." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T09:01:32Z" ; oboInOwl:hasDbXref "MSH:D009205", "SNOMEDCT_US:50920009", "UMLS:C0027059" ; oboInOwl:hasExactSynonym "Inflammation of heart muscle" ; oboInOwl:id "HP:0012819" ; a owl:Class ; rdfs:comment "Myocarditis can be caused by a variety of bacterial and viral infections. Enteroviruses, especially coxsackievirus B, and adenovirus and parvovirus B19 are often associated with acute myocarditis. Exposure to drug treatment, physical stimuli such as radiation and heat, metabolic disorders, immune disorders, and pregnancy are also causes of myocarditis. Many cases of myocarditis are idiopathic. Myocarditis presents with non-specific symptoms including chest pain, dyspnoea, and palpitations, and thus often mimics more common disorders such as coronary artery disease. In some patients, cardiac MRI and endomyocardial biopsy can help identify myocarditis, predict risk of cardiovascular events, and guide treatment." ; rdfs:label "Myocarditis" ; rdfs:subClassOf obo:HP_0001637 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002349 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012820 obo:IAO_0000115 "A loss of the ability to move the vocal fold on both sides." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T09:22:32Z" ; oboInOwl:hasDbXref "UMLS:C2146481" ; oboInOwl:id "HP:0012820" ; a owl:Class ; rdfs:label "Bilateral vocal cord paralysis" ; rdfs:subClassOf obo:HP_0001605 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000763 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0012821 obo:IAO_0000115 "Decreased strength of the vocal fold on one side." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T09:25:11Z" ; oboInOwl:hasDbXref "MSH:D014826", "UMLS:C0751577" ; oboInOwl:id "HP:0012821" ; a owl:Class ; rdfs:label "Unilateral vocal cord paresis" ; rdfs:subClassOf obo:HP_0001604 . obo:HP_0012822 obo:IAO_0000115 "Decreased strength of the vocal fold on both sides." ; dcterms:creator ; oboInOwl:creation_date "2014-05-28T09:25:43Z" ; oboInOwl:hasDbXref "MSH:D014826", "UMLS:C0751574" ; oboInOwl:id "HP:0012822" ; a owl:Class ; rdfs:label "Bilateral vocal cord paresis" ; rdfs:subClassOf obo:HP_0001604 . obo:HP_0012823 obo:IAO_0000115 "This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T06:34:24Z" ; oboInOwl:hasAlternativeId "HP:0000004" ; oboInOwl:hasDbXref "UMLS:C4021064" ; oboInOwl:hasExactSynonym "Phenotypic modifier" ; oboInOwl:id "HP:0012823" ; a owl:Class ; rdfs:comment "Note that some of the terms, such as Intellectual disability, have children terms such as Severe intellectual disability that represent precomposed combinations of modifiers and phenotypic abnormality terms. This done where the medical community commonly uses these terms with a fixed meaning (for instance, the Intellectual disability terms are used with specific IQ ranges). For computational reasoning, the semantics are intended to be the same as if there was a combination of the phenotype term and the clinical modifier term." ; rdfs:label "Clinical modifier" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0012824 obo:IAO_0000115 "The intensity or degree of a manifestation." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T06:39:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:103370009", "UMLS:C0522510" ; oboInOwl:hasExactSynonym "Intensity" ; oboInOwl:id "HP:0012824" ; a owl:Class ; rdfs:comment "Synonymous with PATO:0000049, intensity." ; rdfs:label "Severity" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0012825 obo:IAO_0000115 "Having a relatively minor degree of severity. For quantitative traits, a deviation of between two and three standard deviations from the appropriate population mean." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T06:41:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:446411000124101", "UMLS:C1513302" ; oboInOwl:hasExactSynonym "Mild" ; oboInOwl:id "HP:0012825" ; a owl:Class ; rdfs:comment "PATO:0000394, mild." ; rdfs:label "Mild" ; rdfs:subClassOf obo:HP_0012824 . obo:HP_0012826 obo:IAO_0000115 "Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T06:48:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:446421000124109", "SNOMEDCT_US:6736007", "UMLS:C0205081" ; oboInOwl:id "HP:0012826" ; a owl:Class ; rdfs:comment "PATO:0000395, moderate." ; rdfs:label "Moderate" ; rdfs:subClassOf obo:HP_0012824 . obo:HP_0012827 obo:IAO_0000115 "Having a minor degree of severity that is considered to be on the boundary between the normal and the abnormal ranges. For quantitative traits, a deviation of that is less than two standard deviations from the appropriate population mean." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T06:52:16Z" ; oboInOwl:hasDbXref "UMLS:C0205189" ; oboInOwl:hasExactSynonym "Borderline" ; oboInOwl:id "HP:0012827" ; a owl:Class ; rdfs:comment "PATO:0000394, mild." ; rdfs:label "Borderline" ; rdfs:subClassOf obo:HP_0012824 . obo:HP_0012828 obo:IAO_0000115 "Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:03:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:24484000", "UMLS:C0205082" ; oboInOwl:hasExactSynonym "Severe" ; oboInOwl:id "HP:0012828" ; a owl:Class ; rdfs:comment "PATO:0000396, severe." ; rdfs:label "Severe" ; rdfs:subClassOf obo:HP_0012824 . obo:HP_0012829 obo:IAO_0000115 "Having an extremely high degree of severity. For quantitative traits, a deviation of more than five standard deviations from the appropriate population mean." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:05:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:795002", "UMLS:C0439808" ; oboInOwl:hasExactSynonym "Profound" ; oboInOwl:id "HP:0012829" ; a owl:Class ; rdfs:label "Profound" ; rdfs:subClassOf obo:HP_0012824 . obo:HP_0012830 obo:IAO_0000115 "The anatomical localization of the specified phenotypic abnormality." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:18:35Z" ; oboInOwl:hasDbXref "UMLS:C4019252" ; oboInOwl:id "HP:0012830" ; a owl:Class ; rdfs:label "Position" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0012831 obo:IAO_0000115 "The localization with respect to the side of the body of the specified phenotypic abnormality." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:19:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:272741003", "UMLS:C0332304" ; oboInOwl:id "HP:0012831" ; a owl:Class ; rdfs:label "Laterality" ; rdfs:subClassOf obo:HP_0012830 . obo:HP_0012832 obo:IAO_0000115 "Being present on both sides of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:20:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:51440002", "UMLS:C0238767" ; oboInOwl:id "HP:0012832" ; a owl:Class ; rdfs:label "Bilateral" ; rdfs:subClassOf obo:HP_0012831 . obo:HP_0012833 obo:IAO_0000115 "Being present on only the left or only the right side of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:21:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:66459002", "UMLS:C0205092" ; oboInOwl:id "HP:0012833" ; a owl:Class ; rdfs:label "Unilateral" ; rdfs:subClassOf obo:HP_0012831 . obo:HP_0012834 obo:IAO_0000115 "Being located on the right side of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:21:46Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:264180000", "UMLS:C0444532" ; oboInOwl:hasExactSynonym "Right-sided" ; oboInOwl:id "HP:0012834" ; a owl:Class ; rdfs:label "Right" ; rdfs:subClassOf obo:HP_0012831 . obo:HP_0012835 obo:IAO_0000115 "Being located on the left side of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:23:17Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:263795004", "UMLS:C0443246" ; oboInOwl:hasExactSynonym "Left-sided" ; oboInOwl:id "HP:0012835" ; a owl:Class ; rdfs:label "Left" ; rdfs:subClassOf obo:HP_0012831 . obo:HP_0012836 obo:IAO_0000115 "The pattern by which a phenotype affects one or more regions of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:25:02Z" ; oboInOwl:hasDbXref "UMLS:C4022711" ; oboInOwl:id "HP:0012836" ; a owl:Class ; rdfs:label "Spatial pattern" ; rdfs:subClassOf obo:HP_0012830 . obo:HP_0012837 obo:IAO_0000115 "Affecting all regions without specificity of distribution." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:25:58Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:60132005", "UMLS:C0205246" ; oboInOwl:hasExactSynonym "Generalised" ; oboInOwl:id "HP:0012837" ; a owl:Class ; rdfs:comment "PATO:0002403." ; rdfs:label "Generalized" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0012838 obo:IAO_0000115 "Being confined or restricted to a particular location." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:27:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:255471002", "UMLS:C0392752" ; oboInOwl:hasExactSynonym "Localised", "Localized" ; oboInOwl:id "HP:0012838" ; a owl:Class ; rdfs:comment "PATO:0000627." ; rdfs:label "Localized" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0012839 obo:IAO_0000115 "Localized away from the central point of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:29:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46053002", "UMLS:C0205108" ; oboInOwl:hasExactSynonym "Outermost" ; oboInOwl:id "HP:0012839" ; a owl:Class ; rdfs:label "Distal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0012840 obo:IAO_0000115 "Localized close to the central point of the body." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:30:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:40415009", "UMLS:C0205107" ; oboInOwl:id "HP:0012840" ; a owl:Class ; rdfs:label "Proximal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0012841 obo:IAO_0000115 "The presence of an increased number of twists and turns of the retinal blood vessels." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T07:53:56Z" ; oboInOwl:hasDbXref "UMLS:C1860475" ; oboInOwl:hasExactSynonym "Tortuous retinal vessels" ; oboInOwl:id "HP:0012841" ; a owl:Class ; rdfs:label "Retinal vascular tortuosity" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0012842 obo:IAO_0000115 "A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:02:51Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:126489007", "SNOMEDCT_US:55681005", "UMLS:C0345988" ; oboInOwl:hasExactSynonym "Skin adnexal neoplasm", "Skin adnexal tumor", "Skin adnexal tumour" ; oboInOwl:id "HP:0012842" ; a owl:Class ; rdfs:label "Skin appendage neoplasm" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0011138 . obo:HP_0012843 obo:IAO_0000115 "An uncontrolled autonomous cell-proliferation originating in a hair follicle, which is an epidermal adnexal structures responsible for hair growth." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:03:49Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:44155009", "UMLS:C0859920" ; oboInOwl:id "HP:0012843" ; a owl:Class ; rdfs:label "Hair follicle neoplasm" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0012844 obo:IAO_0000115 "A benign tumor originating from the outer root sheath of the hair follicle." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:05:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:274900003", "SNOMEDCT_US:46199002", "UMLS:C0334263" ; oboInOwl:hasExactSynonym "Tricholemmoma" ; oboInOwl:id "HP:0012844" ; a owl:Class ; rdfs:label "Trichilemmoma" ; rdfs:subClassOf obo:HP_0012843 . obo:HP_0012845 obo:IAO_0000115 "Presence of a unitary trichilemmoma, a benign tumor originating from the outer root sheath of the hair follicle." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:06:37Z" ; oboInOwl:hasDbXref "UMLS:C4022710" ; oboInOwl:id "HP:0012845" ; a owl:Class ; rdfs:label "Single trichilemmoma" ; rdfs:subClassOf obo:HP_0012844 . obo:HP_0012846 obo:IAO_0000115 "Presence of multiple trichilemmomata, a benign tumor originating from the outer root sheath of the hair follicle." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:07:30Z" ; oboInOwl:hasDbXref "UMLS:C4021063" ; oboInOwl:hasExactSynonym "Multiple trichilemmomas" ; oboInOwl:id "HP:0012846" ; a owl:Class ; rdfs:label "Multiple trichilemmomata" ; rdfs:subClassOf obo:HP_0012844 . obo:HP_0012847 obo:IAO_0000115 "Epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years)." ; dcterms:creator ; oboInOwl:creation_date "2014-06-06T08:09:22Z" ; oboInOwl:hasDbXref "MSH:D017036", "SNOMEDCT_US:241006", "UMLS:C0085543" ; oboInOwl:hasExactSynonym "Epilepsia partialis continua of Kojevnikov", "Kojevnikov's epilepsia", "Kozhevnikov's epilepsia" ; oboInOwl:id "HP:0012847" ; a owl:Class ; rdfs:comment "The focal motor features may exhibit a Jacksonian march and a post-ictal (Todd's) paresis may be seen in the affected body part." ; rdfs:label "Epilepsia partialis continua" ; rdfs:subClassOf obo:HP_0032663 . obo:HP_0012848 obo:IAO_0000115 "The narrowing or partial blockage of a portion of the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2014-06-07T09:00:19Z" ; oboInOwl:hasDbXref "UMLS:C0151924" ; oboInOwl:hasExactSynonym "Narrowing of small intestine" ; oboInOwl:id "HP:0012848" ; a owl:Class ; rdfs:label "Small intestinal stenosis" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0012849 obo:IAO_0000115 "Bleeding from the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2014-06-07T09:12:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:70375006", "UMLS:C0520561" ; oboInOwl:hasExactSynonym "Small intestinal bleeding", "Small intestinal haemorrhage", "Small intestinal hemorrhage" ; oboInOwl:id "HP:0012849" ; a owl:Class ; rdfs:label "Small intestinal bleeding" ; rdfs:subClassOf obo:HP_0002244, obo:HP_0002584 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012850 obo:IAO_0000115 "Abnormal small intestinal contractions, such as spasms and intestinal paralysis related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes." ; dcterms:creator ; oboInOwl:creation_date "2014-06-07T09:15:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253768006", "UMLS:C0345200" ; oboInOwl:id "HP:0012850" ; a owl:Class ; rdfs:label "Small intestinal dysmotility" ; rdfs:subClassOf obo:HP_0002579, obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_1990770 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012851 obo:IAO_0000115 "A narrowing of a segment of colon whereby bowel continuity is maintained." ; dcterms:creator ; oboInOwl:creation_date "2014-06-07T09:22:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19132000", "SNOMEDCT_US:8543007", "UMLS:C0267466" ; oboInOwl:hasExactSynonym "Narrowing of the colon", "Stenosis of the colon" ; oboInOwl:id "HP:0012851" ; a owl:Class ; rdfs:label "Colonic stenosis" ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0012852 obo:IAO_0000115 "Hepatic fibrosis that reaches from a portal area to another portal area." ; dcterms:creator ; oboInOwl:creation_date "2014-06-07T09:27:43Z" ; oboInOwl:hasDbXref "UMLS:C4022709" ; oboInOwl:id "HP:0012852" ; a owl:Class ; rdfs:label "Hepatic bridging fibrosis" ; rdfs:subClassOf obo:HP_0001395 . obo:HP_0012853 obo:IAO_0000115 "Hypospadias with location of the urethral meatus in the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T10:56:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:702462000", "UMLS:C2197691" ; oboInOwl:id "HP:0012853" ; a owl:Class ; rdfs:label "Scrotal hypospadias" ; rdfs:subClassOf obo:HP_0000047 . obo:HP_0012854 obo:IAO_0000115 "Hypospadias with location of the urethral meatus in the middle of the inferior shaft of the penis." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T10:57:24Z" ; oboInOwl:hasDbXref "UMLS:C4022708" ; oboInOwl:id "HP:0012854" ; a owl:Class ; rdfs:label "Midshaft hypospadias" ; rdfs:subClassOf obo:HP_0000047 . obo:HP_0012855 obo:IAO_0000115 "Increased pigmentation (skin color) of the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T11:03:38Z" ; oboInOwl:hasDbXref "UMLS:C4021062" ; oboInOwl:hasExactSynonym "Hyperpigmentation of the scrotum", "Hyperpigmented scrotum", "Increased pigmentation in scrotum" ; oboInOwl:id "HP:0012855" ; a owl:Class ; rdfs:comment "This finding may be normal variation but can also be seen with congenital adrenal hyperplasia and other causes of excessive adrenocorticotrophic hormone (ACTH) stimulation." ; rdfs:label "Scrotal hyperpigmentation" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0012856 obo:IAO_0000115 "Anomaly of the folded ridges (wrinkles) of skin of the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T11:10:00Z" ; oboInOwl:hasDbXref "UMLS:C4022707" ; oboInOwl:id "HP:0012856" ; a owl:Class ; rdfs:label "Abnormal scrotal rugation" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0012857 obo:IAO_0000115 "Increased number or density of the folded ridges (wrinkles) of skin of the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T11:12:46Z" ; oboInOwl:hasDbXref "UMLS:C4022706" ; oboInOwl:id "HP:0012857" ; a owl:Class ; rdfs:label "Increased scrotal rugation" ; rdfs:subClassOf obo:HP_0012856 . obo:HP_0012858 obo:IAO_0000115 "Decreased number or density of the folded ridges (wrinkles) of skin of the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T11:14:00Z" ; oboInOwl:hasDbXref "UMLS:C4022705" ; oboInOwl:id "HP:0012858" ; a owl:Class ; rdfs:label "Decreased scrotal rugation" ; rdfs:subClassOf obo:HP_0012856 . obo:HP_0012859 obo:IAO_0000115 "A white patch or plaque occurring on the surface of the esophageal mucous membranes that cannot be rubbed off and cannot be characterized clinically as any other disease." ; dcterms:creator ; oboInOwl:creation_date "2014-06-08T11:16:53Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:89057003", "UMLS:C0267095" ; oboInOwl:hasRelatedSynonym "Esophageal epidermoid metaplasia" ; oboInOwl:id "HP:0012859" ; a owl:Class ; rdfs:label "Esophageal leukoplakia" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0012860 obo:IAO_0000115 "Formation of excess connective tissue in the testicle." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T09:29:22Z" ; oboInOwl:hasDbXref "UMLS:C4021061" ; oboInOwl:hasExactSynonym "Fibrotic testes", "Fibrotic testicle" ; oboInOwl:id "HP:0012860" ; a owl:Class ; rdfs:label "Testicular fibrosis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0012861 obo:IAO_0000115 "A gonad that contains both ovarian follicles and testicular tubular elements." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T09:48:37Z" ; oboInOwl:hasDbXref "MSH:D050090", "SNOMEDCT_US:18978002", "UMLS:C0266361" ; oboInOwl:id "HP:0012861" ; a owl:Class ; rdfs:comment "An ovotestis is usually observed to have connective tissue separating the ovarian components from the testicular components, but ovarian and testicular elements may be intermixed." ; rdfs:label "Ovotestis" ; rdfs:subClassOf obo:HP_0000062 . obo:HP_0012862 obo:IAO_0000115 "Any structural anomaly of a reproductive cell." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:01:49Z" ; oboInOwl:hasDbXref "UMLS:C4022704" ; oboInOwl:hasExactSynonym "Abnormal shape of a reproductive cell", "Abnormally shaped germ cell", "Abnormally shaped reproductive cell" ; oboInOwl:id "HP:0012862" ; a owl:Class ; rdfs:label "Abnormal germ cell morphology" ; rdfs:subClassOf obo:HP_0012243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012863 obo:IAO_0000115 "A structural anomaly of a male reproductive cell." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:05:33Z" ; oboInOwl:hasDbXref "UMLS:C4022703" ; oboInOwl:id "HP:0012863" ; a owl:Class ; rdfs:label "Abnormal male germ cell morphology" ; rdfs:subClassOf obo:HP_0012862 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012864 obo:IAO_0000115 "A structural anomaly of sperm." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:07:03Z" ; oboInOwl:hasDbXref "MSH:D000072660", "SNOMEDCT_US:236817003", "UMLS:C0403824" ; oboInOwl:hasExactSynonym "Abnormal shape of sperm", "Teratospermia", "Teratozoospermia" ; oboInOwl:id "HP:0012864" ; a owl:Class ; rdfs:label "Abnormal sperm morphology" ; rdfs:subClassOf obo:HP_0012863 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012865 obo:IAO_0000115 "A structural abnormality of the sperm head." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:48:21Z" ; oboInOwl:hasDbXref "UMLS:C4022702" ; oboInOwl:hasExactSynonym "Sperm head anomaly" ; oboInOwl:id "HP:0012865" ; a owl:Class ; rdfs:label "Abnormal sperm head morphology" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0012866 obo:IAO_0000115 "A structural abnormality of the sperm neck." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:50:20Z" ; oboInOwl:hasDbXref "UMLS:C4022701" ; oboInOwl:hasExactSynonym "Sperm neck anomaly" ; oboInOwl:id "HP:0012866" ; a owl:Class ; rdfs:comment "The neck of spermatozoa is the site of articulation between the head and tail, and comprises the sperm centriole and connecting piece." ; rdfs:label "Abnormal sperm neck morphology" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0012867 obo:IAO_0000115 "A structural abnormality of the sperm mid-piece." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:50:37Z" ; oboInOwl:hasDbXref "UMLS:C4022700" ; oboInOwl:hasExactSynonym "Sperm mid-piece anomaly" ; oboInOwl:id "HP:0012867" ; a owl:Class ; rdfs:label "Abnormal sperm mid-piece morphology" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0012868 obo:IAO_0000115 "A structural abnormality of the sperm tail." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:50:50Z" ; oboInOwl:hasDbXref "UMLS:C4022699" ; oboInOwl:hasExactSynonym "Sperm tail anomaly" ; oboInOwl:id "HP:0012868" ; a owl:Class ; rdfs:comment "The ultrastructure of the mammalian flagellum is highly conserved and is structurally divided into four major parts: the connecting piece, the mid piece, the principal piece, and the end piece. The axoneme extends from the remnant of the centriole attached to the implantation fossa of the nucleus and is the core structure along the length of the sperm tail. Defective sperm flagella are the principal cause of sperm motility disorders." ; rdfs:label "Abnormal sperm tail morphology" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0012869 obo:IAO_0000115 "Spermatozoa with very small cranial ends devoid of any nuclear material, that is, lacking a typical sperm head." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T10:57:11Z" ; oboInOwl:hasDbXref "UMLS:C4022698" ; oboInOwl:id "HP:0012869" ; a owl:Class ; rdfs:label "Acephalic spermatozoa" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0012870 obo:IAO_0000115 "A condition which is considered to be due to the subsequent atrophy and disappearance in fetal life of an initially normal testis. In the presence of spermatic cord structures is evidence of the presence of the testis in early intrauterine life. When associated with a blind-ending spermatic cord, this entity is named as his absence of a testis in an otherwise normal 46XY male is usually unilateral and is assumed to be a consequence of intrauterine or perinatal torsion or infarction." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:00:13Z" ; oboInOwl:hasDbXref "MSH:C537770", "SNOMEDCT_US:53599007", "UMLS:C0266427" ; oboInOwl:hasExactSynonym "Vanishing testis" ; oboInOwl:hasRelatedSynonym "Testicular regression syndrome" ; oboInOwl:id "HP:0012870" ; a owl:Class ; rdfs:label "Vanishing testis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0012871 obo:IAO_0000115 "A varicocele is a widening of the veins along the spermatic cord, leading to enlarged, twisted veins in the scrotum, and manifested clinically by a painless testicle lump, scrotal swelling, or bulge in the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:07:41Z" ; oboInOwl:hasDbXref "MSH:D014646", "SNOMEDCT_US:46871008", "SNOMEDCT_US:51070004", "UMLS:C0042341" ; oboInOwl:hasExactSynonym "Vaginal varicocele" ; oboInOwl:id "HP:0012871" ; a owl:Class ; rdfs:comment "\"vaginal\" refers to the tunica vaginalis of the testis, not to the vagina." ; rdfs:label "Varicocele" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0012872 obo:IAO_0000115 "A structural anomaly of the secretory duct of the testicle that carries spermatozoa from the epididymis to the prostatic urethra where it terminates to form ejaculatory duct." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:13:37Z" ; oboInOwl:hasDbXref "UMLS:C4022697" ; oboInOwl:id "HP:0012872" ; a owl:Class ; rdfs:label "Abnormal vas deferens morphology" ; rdfs:subClassOf obo:HP_0000022 . obo:HP_0012873 obo:IAO_0000115 "Aplasia (congenital absence) of the vas deferens." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:14:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:300506000", "SNOMEDCT_US:5286009", "SNOMEDCT_US:702610009", "UMLS:C0266444" ; oboInOwl:hasExactSynonym "Absent deferent duct", "Absent ductus deferens", "Congenital absence of the vas deferens" ; oboInOwl:id "HP:0012873" ; a owl:Class ; rdfs:label "Absent vas deferens" ; rdfs:subClassOf obo:HP_0012872 . obo:HP_0012874 obo:IAO_0000115 "An abnormal functionality of the male genital system." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:20:46Z" ; oboInOwl:hasDbXref "UMLS:C4020716" ; oboInOwl:hasRelatedSynonym "Abnormal male genital system physiology" ; oboInOwl:id "HP:0012874" ; a owl:Class ; rdfs:label "Abnormal male reproductive system physiology" ; rdfs:subClassOf obo:HP_0000080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012875 obo:IAO_0000115 "Abnormality in the process of ejection of semen (usually carrying sperm) from the male reproductive tract." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:21:29Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:386674000", "UMLS:C2937350" ; oboInOwl:id "HP:0012875" ; a owl:Class ; rdfs:label "Abnormal ejaculation" ; rdfs:subClassOf obo:HP_0012874 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012876 obo:IAO_0000115 "The emission of semen and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:24:37Z" ; oboInOwl:hasDbXref "MSH:D061686", "SNOMEDCT_US:44001008", "UMLS:C0033038" ; oboInOwl:hasExactSynonym "Premature ejaculation" ; oboInOwl:id "HP:0012876" ; a owl:Class ; rdfs:label "Premature ejaculation" ; rdfs:subClassOf obo:HP_0012875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012877 obo:IAO_0000115 "The emission of semen and seminal fluid into the bladder instead of through the penis during orgasm." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:25:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:50112006", "UMLS:C0403673" ; oboInOwl:id "HP:0012877" ; a owl:Class ; rdfs:label "Retrograde ejaculation" ; rdfs:subClassOf obo:HP_0012875 . obo:HP_0012878 obo:IAO_0000115 "Difficulty of a male in achieving orgasm." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:29:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:15405008", "UMLS:C0234047" ; oboInOwl:hasExactSynonym "Delayed ejaculation" ; oboInOwl:id "HP:0012878" ; a owl:Class ; rdfs:label "Retarded ejaculation" ; rdfs:subClassOf obo:HP_0012875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000502 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012879 obo:IAO_0000115 "Inability to ejaculate." ; dcterms:creator ; oboInOwl:creation_date "2014-06-09T11:33:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:248782001", "SNOMEDCT_US:42288005", "UMLS:C0278106" ; oboInOwl:hasExactSynonym "Ejaculatory incompetence" ; oboInOwl:id "HP:0012879" ; a owl:Class ; rdfs:label "Anejaculation" ; rdfs:subClassOf obo:HP_0012875 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002000 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012880 obo:IAO_0000115 "An anomaly of the labia minora, the folds of skin between the outer labia." ; oboInOwl:creation_date "2014-06-11T07:44:31Z" ; oboInOwl:hasDbXref "UMLS:C4022696" ; oboInOwl:hasExactSynonym "Abnormality of the inner vaginal lips", "Abnormality of the labia minora" ; oboInOwl:id "HP:0012880" ; a owl:Class ; rdfs:label "Abnormal labia minora morphology" ; rdfs:subClassOf obo:HP_0000058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012881 obo:IAO_0000115 "An anomaly of the outer labia." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T07:46:41Z" ; oboInOwl:hasDbXref "UMLS:C4022695" ; oboInOwl:hasExactSynonym "Abnormality of the labia majora", "Abnormality of vaginal lips" ; oboInOwl:id "HP:0012881" ; a owl:Class ; rdfs:label "Abnormal labia majora morphology" ; rdfs:subClassOf obo:HP_0000058 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012882 obo:IAO_0000115 "Overgrowth of the outer labia." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T07:54:42Z" ; oboInOwl:hasDbXref "UMLS:C4021060" ; oboInOwl:hasExactSynonym "Enlarged labia majora", "Hyperplasia of labia majora" ; oboInOwl:id "HP:0012882" ; a owl:Class ; rdfs:label "Hyperplastic labia majora" ; rdfs:subClassOf obo:HP_0012881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004085 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012883 obo:IAO_0000115 "A fluid filled sac located in the Fallopian tube." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T08:00:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:59401005", "UMLS:C0269173" ; oboInOwl:id "HP:0012883" ; a owl:Class ; rdfs:label "Fallopian tube cyst" ; rdfs:subClassOf obo:HP_0011027 . obo:HP_0012884 obo:IAO_0000115 "A twisting of the Fallopian tube. Sudden onset with sharp, colicky pelvic pain associated with nausea, vomiting, bowel, and bladder symptoms is the usual presentation." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T08:01:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46946009", "UMLS:C0269169" ; oboInOwl:hasExactSynonym "Twisted fallopian tube" ; oboInOwl:id "HP:0012884" ; a owl:Class ; rdfs:comment "Fallopian tube torsion, though rare, should be considered in women of reproductive age with unilateral pelvic pain. Early diagnostic laparoscopy is important for an accurate diagnosis and could salvage the tube." ; rdfs:label "Fallopian tube torsion" ; rdfs:subClassOf obo:HP_0011027 . obo:HP_0012885 obo:IAO_0000115 "The presence of a supernumerary Fallopian tube." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T08:05:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:48672005", "UMLS:C0266375" ; oboInOwl:hasExactSynonym "Accessory fallopian tube" ; oboInOwl:id "HP:0012885" ; a owl:Class ; rdfs:comment "Accessory fallopian tube is the congenital anomaly attached to the ampullary part of main tube. This accessory tube is common site of pyosalpinx, hydrosalpinx, cystic swelling and torsion." ; rdfs:label "Fallopian tube duplication" ; rdfs:subClassOf obo:HP_0011027 . obo:HP_0012886 obo:IAO_0000115 "An abdominal mass formed by bleeding into a follicular ovarian cyst or corpus luteum cyst." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T09:26:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:119420007", "UMLS:C0473311" ; oboInOwl:id "HP:0012886" ; a owl:Class ; rdfs:comment "The clinical signs and symptoms of hemorrhagic ovarian cyst (HOC) are variable and include such patients as asymptomatic cases or patients showing symptoms of acute abdomen. HOC is detected as pelvic masses by ultrasonography, but it is often misdiagnosed with other organic masses because of its variable clinical and sonographic findings, and in some cases may lead to laparotomy." ; rdfs:label "Hemorrhagic ovarian cyst" ; rdfs:subClassOf obo:HP_0000138 . obo:HP_0012887 obo:IAO_0000115 "A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T09:32:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:119421006", "UMLS:C0346170", "UMLS:C4020715" ; oboInOwl:hasRelatedSynonym "Serous ovarian cyst" ; oboInOwl:id "HP:0012887" ; a owl:Class ; rdfs:comment "Ovarian serous cystadenoma HAS a malignant potential several times greater than that of mucinous cystadenoma. It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size." ; rdfs:label "Ovarian serous cystadenoma" ; rdfs:subClassOf obo:HP_0000138 . obo:HP_0012888 obo:IAO_0000115 "An anomaly of the neck of the uterus (lower part of the uterus), called the uterine cervix." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T09:40:02Z" ; oboInOwl:hasDbXref "UMLS:C4022694" ; oboInOwl:hasExactSynonym "Abnormality of the uterine cervix" ; oboInOwl:id "HP:0012888" ; a owl:Class ; rdfs:label "Abnormal uterine cervix morphology" ; rdfs:subClassOf obo:HP_0000130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012889 obo:IAO_0000115 "Abnormal growth of endometrial cells (which are normally limited to the uterus) within the cervix." ; dcterms:creator ; oboInOwl:creation_date "2014-06-11T09:42:02Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:61640006", "UMLS:C0269107" ; oboInOwl:id "HP:0012889" ; a owl:Class ; rdfs:label "Cervical endometriosis" ; rdfs:subClassOf obo:HP_0012888, obo:HP_0030127 . obo:HP_0012890 obo:IAO_0000115 "Posterior malposition of the anus." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T10:55:41Z" ; oboInOwl:hasDbXref "UMLS:C4022693" ; oboInOwl:id "HP:0012890" ; a owl:Class ; rdfs:label "Posteriorly placed anus" ; rdfs:subClassOf obo:HP_0004397 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001922 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012891 obo:IAO_0000115 "Hair on the neck extends less inferiorly than usual." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T10:57:10Z" ; oboInOwl:hasDbXref "UMLS:C4022692" ; oboInOwl:hasExactSynonym "High hairline at back of head" ; oboInOwl:id "HP:0012891" ; a owl:Class ; rdfs:label "High posterior hairline" ; rdfs:subClassOf obo:HP_0030141 . obo:HP_0012892 obo:IAO_0000115 "Hypertrophy of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T10:58:42Z" ; oboInOwl:hasDbXref "UMLS:C4022691", "UMLS:C4280307" ; oboInOwl:hasExactSynonym "Increased size of facial muscles", "Large facial muscles" ; oboInOwl:hasRelatedSynonym "Hyperplasia of facial muscles" ; oboInOwl:id "HP:0012892" ; a owl:Class ; rdfs:label "Facial muscle hypertrophy" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0003712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012893 obo:IAO_0000115 "Muscle hypertrophy affecting the muscles of the neck." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T10:59:17Z" ; oboInOwl:hasBroadSynonym "Increased size of neck muscles" ; oboInOwl:hasDbXref "UMLS:C4022690", "UMLS:C4280306" ; oboInOwl:hasExactSynonym "Hypertrophy of cervical muscles", "Large neck muscles", "Overgrowth of neck muscles" ; oboInOwl:hasRelatedSynonym "Hyperplasia of neck muscles" ; oboInOwl:id "HP:0012893" ; a owl:Class ; rdfs:label "Neck muscle hypertrophy" ; rdfs:subClassOf obo:HP_0003712, obo:HP_0011006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012894 obo:IAO_0000115 "Muscle hypertrophy affecting the paraspinal muscles." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T10:59:48Z" ; oboInOwl:hasDbXref "UMLS:C4022689" ; oboInOwl:id "HP:0012894" ; a owl:Class ; rdfs:label "Paraspinal muscle hypertrophy" ; rdfs:subClassOf obo:HP_0003712 . obo:HP_0012895 obo:IAO_0000115 "Muscle hypertrophy affecting the scapular muscles." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:00:11Z" ; oboInOwl:hasDbXref "UMLS:C4022688" ; oboInOwl:id "HP:0012895" ; a owl:Class ; rdfs:label "Scapular muscle hypertrophy" ; rdfs:subClassOf obo:HP_0003712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0034908 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0012896 obo:IAO_0000115 "An anomaly identified by motor evoked potentials (MEPs). MEPs are measured following single-pulse or repetitive transcranial magnetic stimulation and can be used for the assessment of the excitability of the motor cortex and the integrity of conduction along the central and peripheral motor pathways." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:04:24Z" ; oboInOwl:hasDbXref "UMLS:C4022687" ; oboInOwl:id "HP:0012896" ; a owl:Class ; rdfs:label "Abnormal motor evoked potentials" ; rdfs:subClassOf obo:HP_0030178 . obo:HP_0012897 obo:IAO_0000115 "An anomaly identified by motor evoked potentials (MEPs) in the arm." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:08:22Z" ; oboInOwl:hasDbXref "UMLS:C4021059" ; oboInOwl:hasExactSynonym "Abnormal motor evoked potentials in the upper limb" ; oboInOwl:id "HP:0012897" ; a owl:Class ; rdfs:label "Abnormal upper-limb motor evoked potentials" ; rdfs:subClassOf obo:HP_0012896 . obo:HP_0012898 obo:IAO_0000115 "An anomaly identified by motor evoked potentials (MEPs) in the leg." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:09:22Z" ; oboInOwl:hasDbXref "UMLS:C4021058" ; oboInOwl:hasExactSynonym "Abnormal motor evoked potentials in the lower limb" ; oboInOwl:id "HP:0012898" ; a owl:Class ; rdfs:label "Abnormal lower-limb motor evoked potentials" ; rdfs:subClassOf obo:HP_0012896 . obo:HP_0012899 obo:IAO_0000115 "Difficulty releasing one's grip associated with prolonged first handgrip relaxation times." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:10:53Z" ; oboInOwl:hasDbXref "UMLS:C1868623" ; oboInOwl:hasExactSynonym "Grip myotonia" ; oboInOwl:id "HP:0012899" ; a owl:Class ; rdfs:label "Handgrip myotonia" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012900 obo:IAO_0000115 "Slowed relaxation of muscles in the face." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:14:55Z" ; oboInOwl:hasDbXref "UMLS:C4022686" ; oboInOwl:id "HP:0012900" ; a owl:Class ; rdfs:label "Myotonia of the face" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012901 obo:IAO_0000115 "Slowed relaxation of muscles in the jaw." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:18:29Z" ; oboInOwl:hasDbXref "UMLS:C4022685" ; oboInOwl:id "HP:0012901" ; a owl:Class ; rdfs:label "Myotonia of the jaw" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012902 obo:IAO_0000115 "Slowed relaxation of muscles in the leg." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:18:59Z" ; oboInOwl:hasDbXref "UMLS:C4022684" ; oboInOwl:id "HP:0012902" ; a owl:Class ; rdfs:label "Myotonia of the lower limb" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012903 obo:IAO_0000115 "Slowed relaxation of muscles in the arm." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:19:18Z" ; oboInOwl:hasDbXref "UMLS:C4022683" ; oboInOwl:id "HP:0012903" ; a owl:Class ; rdfs:label "Myotonia of the upper limb" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012904 obo:IAO_0000115 "An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation that is induced by exposure to cold." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:20:32Z" ; oboInOwl:hasDbXref "UMLS:C4022682" ; oboInOwl:id "HP:0012904" ; a owl:Class ; rdfs:label "Cold-sensitive myotonia" ; rdfs:subClassOf obo:HP_0002486 . obo:HP_0012905 obo:IAO_0000115 "Euryblepharon is a congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension, with associated lateral canthal malpositioning and lateral ectropion abnormally wide lid opening." ; dcterms:creator ; oboInOwl:creation_date "2014-06-23T11:43:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:400954002", "UMLS:C1303001", "UMLS:C4280305" ; oboInOwl:hasRelatedSynonym "Kabuki syndrome eyelids" ; oboInOwl:id "HP:0012905" ; a owl:Class ; rdfs:comment "The palpebral fissure length may be increased with an enlargement of the palpebral aperture. The lateral part is usually more everted defining euryblepharon. The whole length eversion of the lower lid defines congenital ectropion. Euryblepharon is characteristic of the Kabuki syndrome." ; rdfs:label "Euryblepharon" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0020006 obo:IAO_0000115 "A coloboma of the ciliary body."@en ; oboInOwl:hasDbXref "UMLS:C4072884" ; a owl:Class ; rdfs:label "Ciliary body coloboma" ; rdfs:subClassOf obo:HP_0000589 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020034 obo:IAO_0000115 "A spatial pattern that is spread out, i.e., not localized." ; oboInOwl:hasDbXref "SNOMEDCT_US:19648000", "UMLS:C0205219" ; a owl:Class ; rdfs:label "Diffuse" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0020035 obo:IAO_0000115 "A lack of coordination of leg movement manifested by undershoot or overshoot of the intended position of the leg." ; dc:date "2017-10-13T12:24:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lower limb dysmetria" ; rdfs:subClassOf obo:HP_0002406 . obo:HP_0020036 obo:IAO_0000115 "A lack of coordination of arm movement manifested by undershoot or overshoot of the intended position of the arm." ; dc:date "2017-10-13T12:28:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Upper limb dysmetria" ; rdfs:subClassOf obo:HP_0002406 . obo:HP_0020037 obo:IAO_0000115 "A postural abnormality characterized by the inability to stand without external support despite having sufficient muscle strength." ; dc:date "2017-10-13T12:38:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Astasia" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0020038 obo:IAO_0000115 "Elongation, dilatation, and/or tortuosity of the vertebrobasilar segment. The definition of VBD includes: (i) diameter of basilar or vertebral artery over 4.5 mm; or (ii) deviation of any portion more than 10 mm from the shortest expected course; and (iii) length of basilar artery over 29.5 mm or length of intracranial vertebral artery over 23.5 mm." ; dc:date "2017-10-13T12:54:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The basilar artery arises from the confluence of the two vertebral arteries." ; rdfs:label "Vertebrobasilar dolichoectasia" ; rdfs:subClassOf obo:HP_0030321 . obo:HP_0020041 obo:IAO_0000115 "A type of incomitant strabismus in which both elevator muscles (i.e., the inferior oblique and superior rectus muscles) of the same eye are weak leading to restricted elevation and hypotropia." ; dc:date "2017-12-20T17:09:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Double elevator palsy" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0020042 obo:IAO_0000115 "An ocular movement abnormality characterised by simultaneous weakness of the inferior rectus muscle and superior oblique muscle of the same eye." ; dc:date "2017-12-20T17:12:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Double depressor palsy" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0020043 obo:IAO_0000115 "A type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts upwards and/or downwards." ; dc:date "2017-12-20T17:14:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vertical incomitant strabismus" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0020044 dc:date "2017-12-20T17:14:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts horizontally." ; rdfs:label "Horizontal incomitant strabismus" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0020045 obo:IAO_0000115 "A manifest or latent ocular deviation in which one or both eyes tends to deviate nasally." ; dc:date "2017-12-20T17:20:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Convergent squint", "Convergent strabismus" ; a owl:Class ; rdfs:label "Esodeviation" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0020046 obo:IAO_0000115 "A form of esotropia (convergent deviation of the eyes) associated with activation of the accommodative reflex." ; dc:date "2017-12-20T17:25:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Accommodative esotropia refers to strabismus (cross of the eyes) that occurs with focusing efforts of the eyes." ; rdfs:label "Accommodative esotropia" ; rdfs:subClassOf obo:HP_0000565 . obo:HP_0020047 obo:IAO_0000115 "Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." ; dc:date "2017-12-22T14:32:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal myeloid cell morphology" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000763 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020048 obo:IAO_0000115 "A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19." ; dc:date "2017-12-22T14:57:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced bone-marrow pro-B cell count" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0020049 obo:IAO_0000115 "A manifest or latent ocular deviation in which one or both eyes tends to deviate temporally." ; dc:date "2017-12-22T15:01:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Divergent strabismus" ; a owl:Class ; rdfs:label "Exodeviation" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0020050 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against granulocyte-macrophage colony stimulating factor." ; dc:date "2017-12-22T15:05:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-GM-CSF antibody positivity" ; a owl:Class ; rdfs:comment "Anti-granulocyte macrophage-colony stimulating factor (GM-CSF) autoantibodies have been shown to cause acquired pulmonary alveolar proteinosis (PAP)(1, 2), a chronic lung disease characterized by abnormalities of surfactant metabolism." ; rdfs:label "Anti-granulocyte-macrophage colony stimulating factor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0020054 obo:IAO_0000115 "Any functional abnormality of erythrocytes (red-blood cells)." ; dc:date "2018-09-28T23:39:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal erythrocyte physiology" ; rdfs:subClassOf obo:HP_0001871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000232 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020058 obo:IAO_0000115 "Any deviation from the normal number of red blood cells per volume in the circulation." ; dc:date "2018-09-28T23:44:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal RBC count" ; a owl:Class ; rdfs:label "Abnormal red blood cell count" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0020059 obo:IAO_0000115 "An abnormal elevation above the normal number of red blood cells per volume in the circulation." ; dc:date "2018-09-28T23:45:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased RBC count" ; a owl:Class ; rdfs:label "Increased red blood cell count" ; rdfs:subClassOf obo:HP_0020058 . obo:HP_0020060 obo:IAO_0000115 "An abnormal reduction below the normal number of red blood cells per volume in the circulation." ; dc:date "2018-09-28T23:46:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased RBC count" ; a owl:Class ; rdfs:label "Decreased red blood cell count" ; rdfs:subClassOf obo:HP_0020058 . obo:HP_0020061 obo:IAO_0000115 "Any deviation from the normal concentration of hemoglobin in the blood." ; dc:date "2018-09-28T23:52:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal Hb concentration", "Abnormal haemoglobin concentration" ; a owl:Class ; rdfs:label "Abnormal hemoglobin concentration" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0020062 obo:IAO_0000115 "An abnormal reduction below normal hemoglobin concentration in the circulation." ; dc:date "2018-09-28T23:53:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased Hb concentration", "Decreased haemoglobin concentration" ; a owl:Class ; rdfs:label "Decreased hemoglobin concentration" ; rdfs:subClassOf obo:HP_0020061 . obo:HP_0020063 obo:IAO_0000115 "An abnormal elevation above normal hemoglobin concentration in the circulation." ; dc:date "2018-09-28T23:53:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased Hb concentration", "Increased haemoglobin concentration" ; a owl:Class ; rdfs:label "Increased hemoglobin concentration" ; rdfs:subClassOf obo:HP_0020061 . obo:HP_0020064 obo:IAO_0000115 "Any deviation from the normal number of eosinophils per volume in the blood circulation." ; dc:date "2018-10-17T13:48:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal eosinophil count" ; rdfs:subClassOf obo:HP_0001879, obo:HP_0032309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020071 obo:IAO_0000115 "The presence of virus in the blood." ; dc:date "2019-01-21T22:33:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Viremia" ; rdfs:subClassOf obo:HP_0031863 . obo:HP_0020072 obo:IAO_0000115 "Persistent presence of Epstein-Barr virus in the blood." ; dc:date "2019-01-21T22:36:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Primary EBV infection is often asymptomatic in the immunocompetent host. In immunodeficient patients, however, primary EBV infection or secondary reactivation may result in persistent symptomatic EBV viremia, a clinical condition with a prolonged (over 6 months) and distinct symptomatic phase with fever, lymphadenophathy and several other possible features such as hepatitis and pneumonia. Persistent symptomatic EBV viremia can be associated with lymphoma, lymphoproliferative disease, hemophagocyticlymphohistiocytosis (HLH) and aplastic anemia, but most typically goes into spontaneous remission." ; rdfs:label "Persistent EBV viremia" ; rdfs:subClassOf obo:HP_0032248 . obo:HP_0020073 obo:IAO_0000115 "A white or lighter patch of skin that may appear anywhere on the body and are caused by decreased skin pigmentation." ; dc:date "2019-01-25T13:41:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A reduction in skin pigmentation can be the result of factors such as decreased melanin content or anomalous melanin distribution. In diagnosing pigmentary disorders, Wood's light examination plays an important role, distinguishing hypo- and depigmentation. While a decreased pigment production is reported as hypopigmentation, depigmentation has been defined as loss of pigment. In a similar way, partial lack of melanin is known as hypomelanosis while amelanosis is the total absence of melanin." ; rdfs:label "Hypopigmented macule" ; rdfs:subClassOf obo:HP_0012733 . obo:HP_0020074 obo:IAO_0000115 "The presence of crystals in the urine." ; dc:date "2019-02-25T13:07:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Crystalluria is a marker of urine supersaturation with substances deriving from metabolic disorders, inherited diseases or drugs. The investigation of crystalluria must be done according to a protocol which includes the delivery to the laboratory of a proper urine sample, the use of a microscope equipped with polarized light, the accurate knowledge of urine pH, and a comprehensive examination of the crystals, which is based on their identification, quantification and size measurement. For unusual crystals, infrared spectroscopy may also be needed. The main urinary crystalline categories include: calcium oxalates, calcium phosphates, uric acids and urates, struvite, aminoacids (cystine), purines (2,8-dihydroxyadenine and xanthine) and drugs (e.g. sulfamethoxazole, amoxycillin, ceftriaxone, atazanavir)." ; rdfs:label "Crystalluria" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0020075 obo:IAO_0000115 "The presence of leucine crystals in the urine." ; dc:date "2019-02-25T13:13:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Leucine crystals are oily-looking spheres with concentric striations, which form pseudo-Maltese crosses under polarized light. Leucine, like tyrosine, which appears as thin needles often aggregated inbundles or rosettes, is typical of patients with hepatic failure." ; rdfs:label "Leucine crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0020076 obo:IAO_0000115 "A benign soft tissue tumor of the wrist usually found in the dorsal aspect of the wrist and communicate with the joint via a pedicle. This pedicle usually originates not only at the scapholunate ligament, but also may arise from a number of other sites over the dorsal aspect of the wrist capsule." ; dc:date "2019-02-25T13:18:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ganglion cyst of the wrist" ; a owl:Class ; rdfs:comment "Thirteen to twenty percent of ganglia are found on the volar aspect of the wrist, arising via a pedicle from the radio scaphoid/scapholunate interval, scaphotrapezial joint, or the metacarpotrapezial joint, in that order of frequency." ; rdfs:label "Wrist ganglion" ; rdfs:subClassOf obo:HP_0003019 . obo:HP_0020077 obo:IAO_0000115 "An elevated level of carnitine in the urine." ; dc:date "2019-02-25T13:29:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Carnitine high in urine" ; a owl:Class ; rdfs:label "Carnitinuria" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0020078 obo:IAO_0000115 "An increased level of alanine in the urine." ; dc:date "2019-02-25T13:31:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urinary alanine" ; a owl:Class ; rdfs:label "Alaninuria" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0020079 obo:IAO_0000115 "An increased level of beta-alanine in the urine." ; dc:date "2019-02-25T13:34:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Beta-alanine is a component of carnosine, anserine and pantothenic acid. It is comprised of propionic acid with the amino group in the 3-position." ; rdfs:label "Beta-alaninuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0020080 obo:IAO_0000115 "Nuclear or cytoplasmic aggregates of substances in red blood cells." ; dc:date "2019-02-25T13:41:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Erythrocyte inclusion bodies" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0020081 obo:IAO_0000115 "A type of erythrocyte inclusion characterized by basophilic stippling of erythrocytes, that is, by numerous very small coarse or fine blue granules within the cytoplasm with the additional stipulation that the stippled particles are due to iron granules (demonstrable by the Prussian blue stain)." ; dc:date "2019-02-25T13:56:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pappenheimer bodies" ; rdfs:subClassOf obo:HP_0020080 . obo:HP_0020082 obo:IAO_0000115 "A type of erythrocyte inclusion composed of denatured hemoglobin." ; dc:date "2019-02-25T14:00:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Heinz bodies" ; rdfs:subClassOf obo:HP_0020080 . obo:HP_0020083 obo:IAO_0000115 "An infection of a hair follicle that extends subcutaneously, forming an abscess." ; dc:date "2019-04-08T16:59:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Boil" ; a owl:Class ; rdfs:label "Furuncle" ; rdfs:subClassOf obo:HP_0025084 . obo:HP_0020084 obo:IAO_0000115 "A pustular lesion of the skin emerging from group of infected hair follicles, characterized by a deep location and dissecting through tissue planes. A carbuncle is larger and deeper than a furuncle." ; dc:date "2019-04-08T17:02:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Carbuncle" ; rdfs:subClassOf obo:HP_0025084 . obo:HP_0020085 obo:IAO_0000115 "An infection resulting from live attenuated vaccines (LAV), that is, a vaccine prepared from living viruses or bacteria that have been weakened under laboratory conditions. LAV vaccines will replicate in a vaccinated individual and produce an immune response but usually cause mild or no disease. are derived from disease-causing pathogens." ; dc:date "2019-04-08T17:21:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Infection following live vaccination" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0020086 obo:IAO_0000115 "Local or regional infection with Bacillus Calmette-Guerin (BCG) following vaccination." ; dc:date "2019-04-08T17:25:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The Bacillus Calmette-Guerin (BCG) vaccine has existed for 80 years and is one of the most widely used of all current vaccines. The BCG vaccine has a protective effect against meningitis and disseminated tuberculosis in children. or most children, BCG vaccination is harmless. However, infection, even disseminated infection, caused by BCG has occasionally been reported. The incidence of BCG infection is approximately one in ten thousand to a million. The BCG-induced disease phenotypes were designated as local, regional, distant, or disseminated pattern. The former two patterns were conventionally termed as BCGitis and the latter two as BCGosis." ; rdfs:label "BCGitis" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020087 obo:IAO_0000115 "Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis." ; dc:date "2019-04-08T17:27:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0031698" ; oboInOwl:hasExactSynonym "BCGiosis", "Disseminated Bacillus Calmette-Guerin infection" ; a owl:Class ; rdfs:comment "The Bacillus Calmette-Guerin (BCG) vaccine has existed for 80 years and is one of the most widely used of all current vaccines. The BCG vaccine has a protective effect against meningitis and disseminated tuberculosis in children. or most children, BCG vaccination is harmless. However, infection, even disseminated infection, caused by BCG has occasionally been reported. The incidence of BCG infection is approximately one in ten thousand to a million. The BCG-induced disease phenotypes were designated as local, regional, distant, or disseminated pattern. The former two patterns were conventionally termed as BCGitis and the latter two as BCGosis." ; rdfs:label "BCGosis" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020088 obo:IAO_0000115 "Infection with the measles virus of the live-attenuated vaccine. This is an extremely rare event and may indicate immunocompromise in some cases." ; dc:date "2019-04-08T17:31:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vaccine associated measles" ; a owl:Class ; rdfs:label "Post-vaccination measles" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020089 obo:IAO_0000115 "Infection with the rubella virus of the live-attenuated vaccine." ; dc:date "2019-04-08T17:36:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Post-vaccination rubella" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020090 obo:IAO_0000115 "Infection with live attenuated polio vaccine following vaccination. This is an extreemely rare event that may indicate immunocompromise." ; dc:date "2019-04-08T17:38:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Post-vaccination polio" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020091 obo:IAO_0000115 "Infection with live attenuated rotavirus vaccine following vaccination." ; dc:date "2019-04-08T17:42:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Post-vaccination rotavirus infection" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0020093 obo:IAO_0000115 "Repeated episodes of the formation of abscesses in organs. An abscess is a circumscribed area of pus or necrotic debris in the parenchyma or an organ." ; dc:date "2019-04-08T17:44:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent deep organ abscess formation" ; rdfs:subClassOf obo:HP_0032169 . obo:HP_0020095 obo:IAO_0000115 "Clinical assessment of a requirement to treat with intravenous antibiotics over an unusually prolonged period of time." ; dc:date "2019-04-08T17:48:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Prolonged need of intravenous antibiotic therapy" ; rdfs:subClassOf obo:HP_0032169 . obo:HP_0020096 obo:IAO_0000115 "Increased susceptibility to streptococcal infections, as manifested by recurrent episodes of streptococcal infections." ; dc:date "2019-04-08T17:59:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent streptococcal infections" ; rdfs:subClassOf obo:HP_0002718 . obo:HP_0020097 obo:IAO_0000115 "An infection by an encapsulated bacterial agent. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines." ; dc:date "2019-04-08T18:54:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Encapsulated bacteria have been responsible for the majority of bacteremia and meningitis in children for many decades. In children aged over 3 months, Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae have been the predominant pathogens, with H. influenzae being a less significant problem since the introduction of vaccines against type b organisms. Disease is most common in young children less than 5 years of age and older adults aged over 65 years. In neonates and young infants, Group B Streptococcus (GBS) is the major cause of bacteremia and meningitis. These organisms have the shared characteristic of being surrounded by a polysaccharide capsule, which is a key virulence factor because it helps the bacteria evade complement deposition and subsequent phagocytosis and killing. These polysaccharides have also been the basis for successful vaccines against all except GBS, because immune responses against the polysaccharide capsule are the primary mechanism of protection for the human host. Each species can be encapsulated by polysaccharides of different biochemical compositions, which has been used for categorization into capsular groups or serotypes." ; rdfs:label "Infection due to encapsulated bacteria" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0020098 obo:IAO_0100001 "HP:0012302" ; dc:date "2019-04-08T18:58:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Herpes encephalitis" ; owl:deprecated true . obo:HP_0020099 obo:IAO_0000115 "An unusually severe course of infection with Human norovirus, previously known as Norwalk virus. Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen. Norovirus infection-associated illness may also be more prolonged and severe in immunocompromised individuals and may be associated with remarkably persistent viral excretion in some of these individuals." ; dc:date "2019-04-08T19:02:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe norovirus infection" ; rdfs:subClassOf obo:HP_0032169 . obo:HP_0020100 obo:IAO_0000115 "An unusual fungal infection that is regarded as a sign of a pathological susceptibility to infection by a fungal agent." ; dc:date "2019-04-08T19:05:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual fungal infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0020101 obo:IAO_0000115 "Fungal infection characterized by invasion of host tissues." ; dc:date "2019-04-08T19:11:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Invasive fungal infections are a significant health problem in immunocompromised patients. Major risk factors for IFI include neutropenia less than 500 neutrophils/ml for more than 10 days, haematological malignancies, bone marrow transplantation, prolonged (over 4 wk) treatment with corticosteroids; prolonged (over 7 days) stays in intensive care, chemotherapy, HIV infection, invasive medical procedures, and the newer immune suppressive agents." ; rdfs:label "Invasive fungal infection" ; rdfs:subClassOf obo:HP_0020100 . obo:HP_0020102 obo:IAO_0000115 "An opportunistic disease caused by invasion of unicellular fungus Pneumocystis jirovecii. Transmission of P. jirovecii cysts takes place through the airborne route, and usually, its presence in lungs is asymptomatic. However, people with impaired immunity, especially those with CD4+ T cell count below 200/microliter, are still at risk of the development of Pneumocystis pneumonia due to P. jirovecii invasion. Symptoms induced by this disease are not specific: progressive dyspnoea, non-productive cough, low-grade fever, arterial partial pressure of oxygen below 65 mmHg, and chest radiographs demonstrating bilateral, interstitial shadowing." ; dc:date "2019-04-08T19:15:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pneumocystis, initially considered to be a protozoan, later has been assigned to the kingdom of fungi." ; rdfs:label "Pneumocystis jirovecii pneumonia" ; rdfs:subClassOf obo:HP_0032255 . obo:HP_0020103 obo:IAO_0000115 "Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis." ; dc:date "2019-04-08T19:17:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Invasive pulmonary aspergillosis usually occurs in severely immunocompromised patients. Classic at-risk patients are those with prolonged neutropenia, either due to chemotherapy or immunosuppressive therapy, post hematopoietic stem cell transplant (SCT), or solid organ transplant." ; rdfs:label "Invasive pulmonary aspergillosis" ; rdfs:subClassOf obo:HP_0020101 . obo:HP_0020104 obo:IAO_0000115 "An unusual protozoan infection that is regarded as a sign of a pathological susceptibility to infection by a protozoal agent." ; dc:date "2019-04-08T19:21:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual protozoan infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0020105 obo:IAO_0000115 "Toxoplasmosis is a widespread parasitic infection that is frequently asymptomatic in immunocompetent patients. However, this obligate intracellular protozoan parasite can evade the immune system and persist for the life of its host in cyst form, predominantly in the brain, retina, and muscles. Reactivation of latent cysts may occur when the immune system fails to maintain cytokine pressure, which mainly relies on gamma interferon (IFN-gamma). Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs)." ; dc:date "2019-04-08T19:22:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe toxoplasmosis" ; rdfs:subClassOf obo:HP_0020104 . obo:HP_0020106 obo:IAO_0000115 "An unusually severe infection due to Giardia lamblia, also called Giardia duodenalis or Giardia intestinalis, which is a protozoan parasite of the small intestine that causes extensive morbidity worldwide." ; dc:date "2019-04-08T19:25:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Several reports of giardiasis in immunocompromised patients exist." ; rdfs:label "Severe giardiasis" ; rdfs:subClassOf obo:HP_0020104 . obo:HP_0020107 obo:IAO_0000115 "An unusual helminthic infection that is regarded as a sign of a pathological susceptibility to infection by a worm (helminth)." ; dc:date "2019-04-08T19:28:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual helminthic infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0020108 obo:IAO_0000115 "An unusual parasitic infection that is regarded as a sign of a pathological susceptibility to infection by a parasite." ; dc:date "2019-04-08T19:30:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual parasitic infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0020110 obo:IAO_0000115 "A partial or complete breakage of the continuity of a bone." ; dc:date "2019-04-08T20:45:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bone fracture" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020111 obo:IAO_0000115 "A deviation from the normal proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." ; dc:date "2019-04-08T20:48:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CD4+CD25+ Treg cell proportion" ; a owl:Class ; rdfs:comment "Identification of Treg cells remains problematic, because accumulating evidence suggests that all the presently-used Treg markers (CD25, CTLA-4, GITR, LAG-3, CD127 and Foxp3) represent general T-cell activation markers, rather than being truly Treg-specific." ; rdfs:label "Abnormal CD4+CD25+ regulatory T cell proportion" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020112 obo:IAO_0000115 "An abnormally increased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." ; dc:date "2019-04-08T20:50:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of CD4+CD25+ regulatory T cells", "Increased proportion of CD4+CD25+ Treg cells" ; a owl:Class ; rdfs:label "Increased proportion of CD4+CD25+ regulatory T cells" ; rdfs:subClassOf obo:HP_0020111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020113 obo:IAO_0000115 "An abnormally decreased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." ; dc:date "2019-04-08T20:51:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+CD25+ Treg cells", "Reduced proportion of CD4+CD25+ regulatory T cells" ; a owl:Class ; rdfs:label "Decreased proportion of CD4+CD25+ regulatory T cells" ; rdfs:subClassOf obo:HP_0020111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000792 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020114 obo:IAO_0000115 "Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease." ; dc:date "2019-04-08T20:54:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic HPV infection", "Persistent HPV infection" ; a owl:Class ; rdfs:label "Persistent human papillomavirus infection" ; rdfs:subClassOf obo:HP_0032169 . obo:HP_0020117 obo:IAO_0000115 "Underdeveloped hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T14:49:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "With this feature, the intracellular attachment plates may be thinner than usualler or separated into small, triangular segments. The thickness of the hemidesmosomes may be less than usual." ; rdfs:label "Hypoplastic dermoepidermal hemidesmosomes" ; rdfs:subClassOf obo:HP_0032449 . obo:HP_0020118 obo:IAO_0000115 "Congenital absence of the radial artery." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T16:30:41Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Radial artery aplasia" ; rdfs:subClassOf obo:HP_0031640 . obo:HP_0020119 obo:IAO_0000115 "A structural abnormality of the retinal nerve fiber layer" ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T16:34:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Abnormal retinal nerve fibre layer morphology" ; a owl:Class ; rdfs:comment "The retinal nerve fiber layer consists of unmyelinated ganglion cell axons coursing on the vitreal surface of the retina to the optic disk. These axons become myelinated after entering the optic nerve." ; rdfs:label "Abnormal retinal nerve fiber layer morphology" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0020120 obo:IAO_0000115 "Swelling (edema) of the retinal nerve fibers." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T16:39:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Retinal nerve fibre oedema" ; a owl:Class ; rdfs:label "Retinal nerve fiber edema" ; rdfs:subClassOf obo:HP_0020119 . obo:HP_0020121 obo:IAO_0000115 "A history of conception by an assisted reproductive technology such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T16:46:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Assisted reproductive technology is used primarily for infertility treatments to achieve pregnancy." ; rdfs:label "Conception by assisted reproductive technology" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0020122 obo:IAO_0000115 "Red blood cells that appear to have parts of them bitten away." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T20:24:07Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Blister cells", "Degmacytes" ; a owl:Class ; rdfs:comment "This feature can be observed with acute hemolytic anemia (AHA) related to glucose-6-phosphate dehydrogenase (G6PD) deficiency. In this disorder, AHA can be triggered by ingestion of fave beans, infections, and certain medications. The blood film can show poikilocytosis with bite cells." ; rdfs:label "Bite cells" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0020123 obo:IAO_0000115 "A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T20:36:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Tympanic calcification" ; a owl:Class ; rdfs:comment "Plaques related to tympanosclerosis do not form spherical lesions and are typically within the drum substance itself which is normally easily discerned when using the binocular view of a microscope rather than the monocular, two-dimensional view of a hand-held otoscope. Such plaques can alter compliance of the tympanic membrane and can lead to sclerotic fixation of the ossicles, both of which can result in a mild conductive hearing loss. Histologically, lesions vary slightly according to their stage of development showing differing amounts of increased fibroblasts, abnormal fibers, areas of hyalinization, and areas of calcification into an osseous-like matrix. Most patients require no treatment." ; rdfs:label "Tympanosclerosis" ; rdfs:subClassOf obo:HP_0008609 . obo:HP_0020125 obo:IAO_0000115 "Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma." ; dcterms:creator ; oboInOwl:creation_date "2019-07-02T22:49:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Conjunctival avascular cysts (filtering blebs)", "Spontaneous filtering bleb" ; a owl:Class ; rdfs:label "Spontaneous conjunctival filtering bleb" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0020126 obo:IAO_0000115 "A lump detected in the prostate. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction." ; dcterms:creator ; oboInOwl:creation_date "2019-07-03T17:10:08Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The word mass is often used interchangeably with tumor, which derives from the Latin word tumor that originally meant any form of swelling. A small mass may be asymptomatic. Larger masses may cause pain if they press on a nerve or organ, or may lead to other manifestations depending on their location. In general, the finding of a mass will lead to a workup to determine the nature of the mass." ; rdfs:label "Prostate mass" ; rdfs:subClassOf obo:HP_0008775 . obo:HP_0020127 obo:IAO_0000115 "A lump detected in the region that surrounds a joint. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction." ; dcterms:creator ; oboInOwl:creation_date "2019-07-03T17:35:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The word mass is often used interchangeably with tumor, which derives from the Latin word tumor that originally meant any form of swelling. A small mass may be asymptomatic. Larger masses may cause pain if they press on a nerve or organ, or may lead to other manifestations depending on their location. In general, the finding of a mass will lead to a workup to determine the nature of the mass." ; rdfs:label "Periarticular soft-tissue mass" ; rdfs:subClassOf obo:HP_0001367 . obo:HP_0020128 obo:IAO_0000115 "Aplasia (congenital absence) of the olfactory tract, which causes anosmia, a complete loss of the sense of smell." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T15:49:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Aplasia of the olfactory tract" ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002265 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020129 obo:IAO_0000115 "Any deviation of the concentration of one or more proteins in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T16:29:22Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal urine protein level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0020130 obo:IAO_0000115 "An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter)." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T16:30:20Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Increased urinary NGAL" ; a owl:Class ; rdfs:comment "An increased urinary NGAL concentration may indicate tubular injury." ; rdfs:label "Increased urinary neutrophil gelatinase-associated lipocalin" ; rdfs:subClassOf obo:HP_0020129 . obo:HP_0020131 obo:IAO_0000115 "Abnormal structure of the basement membrane of the renal tubulus." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T16:55:32Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal tubular basement membrane morphology" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0020132 obo:IAO_0000115 "Increase in thickness of the basement membrane of the tubulus of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T16:56:26Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Thickening of the tubular basement membrane" ; rdfs:subClassOf obo:HP_0020131 . obo:HP_0020133 obo:IAO_0000115 "Increased visceral epithelial cell size, with or without cytoplasmic protein droplets." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:07:56Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Glomerular visceral epithelial cell hypertrophy", "Hypertrophy of visceral epithelial cells" ; a owl:Class ; rdfs:comment "Podocytes, also called visceral glomerular epithelial cells, are terminally differentiated cells that line the outer surface of the glomerular basement membrane. Podocytes prevent protein leakage into the urinary space, and also provide important tensile strength to the glomerular capillaries, by opposing the hydrostatic pressure from within. In contrast to glomerular endothelial and mesangial cells, podocytes do not typically proliferate. Studies have shown that following podocyte loss, the inability of podocytes to proliferate contributes to the development of glomerulosclerosis. Consequently, in order to cover the denuded glomerular basement membrane, podocytes increase in size due to hypertrophy. Although this is initially compensatory, podocyte hypertrophy is likely maladaptive, and contributes to glomerulosclerosis." ; rdfs:label "Podocyte hypertrophy" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0020134 obo:IAO_0000115 "Abnormally increased count of neutrophils in urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:23:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Increased urine neutrophil count" ; rdfs:subClassOf obo:HP_0012085 . obo:HP_0020135 obo:IAO_0000115 "A mesenchymal neoplasm characterized by solitary or multiple nodules involving the skin, striated muscles, bones and, sometimes, viscera. It usually appears as a subcutaneous nodule, but can also appear as an ulcer, pedunculated lesion, or similar to a hemangioma. Histology shows well-circumscribed tapered cell lobes, resembling smooth muscle cells. At its center, perivascular round cells (hemangiopericitoides) are usually observed, giving a biphasic appearance." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:28:59Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Myofibromatosis" ; rdfs:subClassOf obo:HP_0031459 . obo:HP_0020136 obo:IAO_0000115 "The presence of circulating IgG autoantibodies to cardiolipin." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:39:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Anticardiolipin IgG antibody positivity" ; rdfs:subClassOf obo:HP_0003613 . obo:HP_0020137 obo:IAO_0000115 "The presence of circulating IgM autoantibodies to cardiolipin." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:41:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Anticardiolipin IgM antibody positivity" ; rdfs:subClassOf obo:HP_0003613 . obo:HP_0020138 obo:IAO_0000115 "Medical history of a recent bite injury due to an animal." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:44:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The spectrum of injury is broad and infectious complications, generally due to unusual pathogens, are common." ; rdfs:label "History of recent animal bite" ; rdfs:subClassOf obo:HP_4000144 . obo:HP_0020139 obo:IAO_0000115 "Medical history of a recent bite injury due to an insect." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:46:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "History of recent insect bite" ; rdfs:subClassOf obo:HP_4000144 . obo:HP_0020140 obo:IAO_0000115 "Medical history of a recent bite injury due to a tick." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:48:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "History of recent tick bite" ; rdfs:subClassOf obo:HP_0020139 . obo:HP_0020141 obo:IAO_0000115 "An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the legs being much higher than the blood pressure measure in the arms. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:52:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Blood pressure substantially higher in lower than upper extremities", "Blood pressure substantially lower in arms than legs", "Blood pressure substantially lower in upper than lower extremities" ; a owl:Class ; rdfs:comment "This feature may be seen, for instance, in Takayasu arteritis." ; rdfs:label "Blood pressure substantially higher in legs than arms" ; rdfs:subClassOf obo:HP_0030972 . obo:HP_0020142 obo:IAO_0000115 "An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the arms being much higher than the blood pressure measure in the legs. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T17:56:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Blood pressure substantially higher in upper than lower extremities", "Increased arm-leg blood pressure gradient" ; a owl:Class ; rdfs:comment "This feature can be observed in aortic coarctation." ; rdfs:label "Blood pressure substantially higher in arms than legs" ; rdfs:subClassOf obo:HP_0030972 . obo:HP_0020143 obo:IAO_0000115 "A cyst in the trachea, whose wall is made up by tissue similar to the bronchial tree, including cartilage and smooth muscle, and is lined by secretory respiratory epithelium composed of cuboid or columnar ciliated epithelium." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:01:46Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Tracheal duplication cyst is a rare congenital malformation presenting in childhood with stridor or dysphagia from a mass effect on the trachea or esophagus. The features of the tracheal duplication cyst are similar to those of bronchogenic duplication cyst and laryngeal duplication cyst, but with histopathological features of the trachea. The trachea is known to originate from the respiratory diverticulum, a ventral outpouching of foregut lumen. The postulated embryological basis of a tracheal duplication cyst may be similar to that of the anomalous bronchi and is a result of abnormal budding of the bronchial tree during the fourth to sixth weeks of embryogenesis." ; rdfs:label "Tracheal duplication cyst" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0020144 obo:IAO_0000115 "The presence of calcium phosphate crystals in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:05:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Calcium phosphate crystals are pleiomorphic, often appearing as birefringent stars or needles, occurring in isolation or in clumps. Plates are granular and non-birefringent." ; rdfs:label "Calcium phosphate crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0020145 obo:IAO_0000115 "The presence of calcium oxalate crystals in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:06:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "There are two types of calcium oxalate crystals, the dihydrate (or Wedellite) and the monohydrate (orWhewellite), which are frequently found together in the same sample. The former have mostly a typical bipyramidal shape, while the latter are more pleiomorphic, although the ovoid shape is the most frequent. Bipyramidal crystals are birefringent only when large or in aggregates, but even then birefringence is usually not intense. The monohydrates, however, are always strongly birefringent. Calcium oxalate may be found in normal subjects, often as a consequence of ingestion of foods like chocolate, beet-root, peanuts, rhubarb, spinach, etc., in stoneformers, in patients with hyperoxaluria, or after ethylene glycol poisoning." ; rdfs:label "Calcium oxalate crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0020146 obo:IAO_0000115 "The presence of calcium carbonate crystals in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:11:59Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Calcium carbonate crystals usually appear as clumped granules." ; rdfs:label "Calcium carbonate crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0020147 obo:IAO_0000115 "Increased concentration of 2-methylbutyryl glycine in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:25:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "This phenotype can be related to a defect in the degradation pathway of L- isoleucine leading to increased urinary excretion of 2-methylbutyryl glycine." ; rdfs:label "2-Methylbutyryl glycinuria" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0020148 obo:IAO_0000115 "An abnormally elevated concentration od mead acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:33:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Elevated serum Mead acid as a proportion of total fatty acids is an indirect marker of a deficiency of essential fatty acids." ; rdfs:label "Increased circulating mead acid level" ; rdfs:subClassOf obo:HP_0003455 . obo:HP_0020149 obo:IAO_0000115 "An increase concentration of succinate in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:49:33Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Elevated circulating succinate" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0020150 obo:IAO_0000115 "The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T19:52:14Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Elevated urinary Tamm-Horsfall protein concentration" ; a owl:Class ; rdfs:comment "Uromodulin (also known as Tamm Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. Levels of uromodulin in the urine and in the blood, where it is present in lower amounts, are valuable biomarkers for tubular mass and renal function." ; rdfs:label "Elevated urinary uromodulin level" ; rdfs:subClassOf obo:HP_0034885 . obo:HP_0020151 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T20:03:40Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Anti-DNA antibodies can be observed in persons with systemic lupus erythematosus (SLE), being a formal classification criterion." ; rdfs:label "Anti-dsDNA antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0020152 obo:IAO_0000115 "Lack of stability of a distal joint (e.g., finger)." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T20:21:18Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Distal joint laxity" ; rdfs:subClassOf obo:HP_0001388 . obo:HP_0020153 obo:IAO_0000115 "Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T21:01:45Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Positive blood 1,3 beta glucan test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0020154 obo:IAO_0000115 "A type of epidermal nevus characterized by closely arranged, dilated follicular openings with keratinous plugs resembling classical comedones." ; dcterms:creator ; oboInOwl:creation_date "2019-07-05T21:03:08Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Nevus comedonicus has a predilection for the face and neck area. Nevus comedonicus presents with grouped, dilated, plugged follicular ostia in a honeycomb pattern. The plugged ostia contain lamellated keratinaceous material. Their appearance resembles black dots but the material cannot be easily removed mechanically in contrast to acne comedones. Nevus comedonicus lesions might present with various patterns of distribution: unilateral, bilateral, linear, interrupted, segmental, or blaschkoid." ; rdfs:label "Nevus comedonicus" ; rdfs:subClassOf obo:HP_0010816 . obo:HP_0020155 obo:IAO_0000115 "An abnormal structure of the female germ cell (egg cell)." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T18:45:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal oocyte morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0020156 obo:IAO_0000115 "Abnormal structure of the oocyte extracellular matrix region known as teh zona pellucida." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T18:49:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "During mammalian fertilization, sperm need to reach the cumulus-oocyte complex, get through the hyaluronic matrix of the cumulus and penetrate the zona pellucida (ZP) in order to fuse with the egg." ; rdfs:label "Abnormal zona pellucida morphology" ; rdfs:subClassOf obo:HP_0020155 . obo:HP_0020157 obo:IAO_0000115 "Reduced thickness of the zona pellucida." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T18:52:13Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Thin zona pellucida" ; rdfs:subClassOf obo:HP_0020156 . obo:HP_0020158 obo:IAO_0000115 "An increased concentration of adrenic acid (also known as cis-7,10,13,16-Docosatetraenoic acid) in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T19:34:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Increased circulating docosatetraenoate level" ; a owl:Class ; rdfs:label "Increased circulating adrenic acid concentration" ; rdfs:subClassOf obo:HP_0004359 . obo:HP_0020159 obo:IAO_0000115 "Failure of the gonadotropin-releasing hormone (GnRH) stimulation test to induce an appropriate increased in luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T19:39:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Reduce response to GnRH stimulation test" ; a owl:Class ; rdfs:label "Reduced response to gonadotropin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0031279 . obo:HP_0020160 obo:IAO_0000115 "Cellular accumulation of GM1 gangliosides." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T19:48:26Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "At the neuropathological level, severe infantile GM1-gangliosidosis patients exhibit distended neurons that contain typical lamellar inclusions referred to as membranous cytoplasmic bodies which are also found in other lipidoses. Although neurons are the primary target for storage, astrocytes may also appear abnormally vacuolated. Neuronal pathology in late onset forms is delayed and tends to be more severe in deeper structures of the brain than in the cortex. Inclusions in the liver are of fibrillar nature and are different from the lamellar bodies in neurons. Abnormal accumulation of GM1-ganglioside and, to a much lesser extent, its asialo-derivative GA1, in the brain is the most prominent biochemical feature." ; rdfs:label "GM1-ganglioside accumulation" ; rdfs:subClassOf obo:HP_0004345 . obo:HP_0020161 obo:IAO_0000115 "Blockage of a branch of the retinal artery. This can cause loss of a section of visual field." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T20:57:42Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Branch retinal artery occlusion" ; rdfs:subClassOf obo:HP_0025326 . obo:HP_0020163 obo:IAO_0000115 "Blockage of the cilioretinal artery. The central retinal artery supplies the inner retina and the surface of the optic nerve. In some individuals, the cilioretinal artery, a branch of the ciliary circulation, may supply a portion of the retina including the macula. In cilioretinal artery occlusion, vision loss results from cell death in the inner retinal layers (mainly ganglion cells) despite relative sparing of the outer layers." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:01:57Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Cilioretinal artery occlusion" ; rdfs:subClassOf obo:HP_0025326 . obo:HP_0020164 obo:IAO_0000115 "A partial or complete obstruction of the ophthalmic artery (branch of the internal carotid artery) that may lead to severe ischemia of the affected globe and associated ocular tissues. It can present with a similar picture to central retinal artery occlusion; however, profound choroidal ischaemia also occurs." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:05:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Ophthalmic artery occlusion" ; rdfs:subClassOf obo:HP_0025326 . obo:HP_0020165 obo:IAO_0000115 "Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:08:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Branch retinal vein occlusion" ; rdfs:subClassOf obo:HP_0012636 . obo:HP_0020166 obo:IAO_0000115 "Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:10:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Central retinal vein occlusion" ; rdfs:subClassOf obo:HP_0012636 . obo:HP_0020167 obo:IAO_0000115 "A variant of central retinal vein occlusions that involves the superior or inferior half of the retina." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:12:32Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Hemiretinal vein occlusion" ; rdfs:subClassOf obo:HP_0012636 . obo:HP_0020169 obo:IAO_0000115 "An anomalous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:39:59Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal drug response" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0020170 obo:IAO_0000115 "High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:41:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Elevated blood drug concentration", "Elevated plasma drug concentration", "Elevated serum drug concentrations", "Increased plasma drug concentration", "Increased serum drug concentration" ; a owl:Class ; rdfs:label "Increased blood drug concentration" ; rdfs:subClassOf obo:HP_0020169 . obo:HP_0020171 obo:IAO_0000115 "Low plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:44:04Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Decreased plasma drug concentration", "Decreased serum drug concentration", "Reduced blood drug concentration", "Reduced plasma drug concentration", "Reduced serum drug concentrations" ; a owl:Class ; rdfs:label "Decreased blood drug concentration" ; rdfs:subClassOf obo:HP_0020169 . obo:HP_0020172 obo:IAO_0000115 "An unpleasant or harmful reaction resulting from treatment with a drug." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:45:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Adverse drug reaction", "Drug-induced reaction", "Drug-induced response", "Toxic drug response" ; a owl:Class ; rdfs:label "Adverse drug response" ; rdfs:subClassOf obo:HP_0020169 . obo:HP_0020173 obo:IAO_0000115 "Decreased response to a drug intervention in comparison to the expected response." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:46:54Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Decreased drug efficacy" ; a owl:Class ; rdfs:label "Reduced drug efficacy" ; rdfs:subClassOf obo:HP_0020169 . obo:HP_0020174 obo:IAO_0000115 "Absent or significantly reduced efficacy of drug intervention characterized by lack of measurable benefit or deterioration of disease course." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T21:47:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Drug resistance" ; a owl:Class ; rdfs:label "Refractory drug response" ; rdfs:subClassOf obo:HP_0020169 . obo:HP_0020175 obo:IAO_0000115 "A decreased amount of cholinesterase in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T22:04:04Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Serum cholinesterase (butyrylcholinesterase (BChE)) is an enzyme that hydrolyzes acetylcholine. BChE is synthetized in the liver and has conventionally been used as a liver function test." ; rdfs:label "Reduced cholinesterase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0020176 obo:IAO_0000115 "The presence of cholesterol crystals in the urine." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T22:11:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Cholesterol crystals are transparent plates with well-defined edges and corners, which polarize light inconstantly. They are not found in normal subjects, and characteristically occur in patients with lipiduria secondary to nephrotic syndrome." ; rdfs:label "Cholesterol crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0020177 obo:IAO_0000115 "An abnormal proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T22:18:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Abnormal proportion of effector memory CD8-positive, alpha-beta T cells, terminally differentiated" ; a owl:Class ; rdfs:label "Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells" ; rdfs:subClassOf obo:HP_0410380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0020178 obo:IAO_0000115 "A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." ; dcterms:creator ; oboInOwl:creation_date "2019-07-06T22:25:02Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Dendritic cells (DC), the professional antigen-pre-senting cells that prime specific immune responses,comprise a very small percentage of circulating whiteblood cells." ; rdfs:label "Abnormal dendritic cell count" ; rdfs:subClassOf obo:HP_0011893 . obo:HP_0020179 obo:IAO_0000115 "A deviation from the normal concentration of haptoglobin in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-11T20:28:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Abnormal haptoglobin level" ; a owl:Class ; rdfs:comment "Haptoglobin is primarily produced in the liver and is functionally important for binding free hemoglobin fromlysed red cells in vivo, preventing its toxic effects." ; rdfs:label "Abnormal circulating haptoglobin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0020180 obo:IAO_0000115 "An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation." ; dcterms:creator ; oboInOwl:creation_date "2019-07-11T20:30:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Elevated haptoglobin level" ; rdfs:subClassOf obo:HP_0020179 . obo:HP_0020181 obo:IAO_0000115 "An abnormally low concentration of haptoglobin in the blood circulation. Decreased haptoglobin in conjunction with increased reticulocyte count and anemia may indicate hemolysis. Decreased haptoglobin levels can also occur in the absence of hemolysis, due to cirrhosis of the liver, disseminated ovarian carcinomatosis, pulmonary sarcoidosis, and elevated estrogen state." ; dcterms:creator ; oboInOwl:creation_date "2019-07-11T20:36:13Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Reduced haptoglobin level" ; rdfs:subClassOf obo:HP_0020179 . obo:HP_0020182 obo:IAO_0000115 "A measurable change in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." ; dcterms:creator ; oboInOwl:creation_date "2019-07-24T16:39:04Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Abnormal A-type atrial natriuretic peptide level" ; a owl:Class ; rdfs:label "Abnormal circulating A-type atrial natriuretic peptide concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0020183 obo:IAO_0000115 "A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." ; dcterms:creator ; oboInOwl:creation_date "2019-07-24T16:40:06Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Increased circulating A-type natriuretic peptide level" ; a owl:Class ; rdfs:label "Increased circulating A-type natriuretic peptide concentration" ; rdfs:subClassOf obo:HP_0020182 . obo:HP_0020184 obo:IAO_0000115 "A measurable reduction in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." ; dcterms:creator ; oboInOwl:creation_date "2019-07-24T16:42:47Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Decreased circulating A-type natriuretic peptide level" ; a owl:Class ; rdfs:label "Decreased circulating A-type natriuretic peptide concentration" ; rdfs:subClassOf obo:HP_0020182 . obo:HP_0020185 obo:IAO_0000115 "Abnormal morphological development of the superior part of the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T12:21:50Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Superior cerebellar dysplasia" ; rdfs:subClassOf obo:HP_0007033 . obo:HP_0020186 obo:IAO_0000115 "The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T12:36:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Multi-lobulated spleen" ; a owl:Class ; rdfs:comment "Sometimes a splenic lobule may extend medially anterior to the upper pole of the left kidney and less often posterior to the upper pole of the left kidney. Although these lobules are not of any clinical importance, close relation of the splenic lobule to the upper pole of the left kidney may cause misinterpretations as a mass originating from the kidney by the radiologists." ; rdfs:label "Multilobulated spleen" ; rdfs:subClassOf obo:HP_0025408 . obo:HP_0020187 obo:IAO_0000115 "Pachygyria with a very thick cerebral cortex measuring 10-20 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T12:56:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Pachygyria with cortical thickness > 10 mm", "Pachygyria with cortical thickness above 10 mm" ; a owl:Class ; rdfs:label "Thick pachygyria" ; rdfs:subClassOf obo:HP_0001302 . obo:HP_0020188 obo:IAO_0000115 "Pachygyria with cortical thickness between 5 and 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically over 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T12:58:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Anterior predominant pachygyria with 5-10 mm cortical thickness" ; rdfs:subClassOf obo:HP_0020192 . obo:HP_0020189 obo:IAO_0000115 "Pachygyria with cortical thickness above 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T13:01:16Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Occipital predomimant classic pachygyria", "Pachygyria with cortical thickness over 10 mm posterior predominant" ; a owl:Class ; rdfs:label "Posterior predominant thick cortex pachygyria" ; rdfs:subClassOf obo:HP_0020187 . obo:HP_0020190 obo:IAO_0000115 "Pachygyria with cortical thickness greater than 10 mm and a perisylvian predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Perisylvian predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T13:03:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Pachygyria with cortical thickness > 10 mm perisylvian predominant" ; a owl:Class ; rdfs:label "Perisylvian predominant thick cortex pachygyria" ; rdfs:subClassOf obo:HP_0020187 . obo:HP_0020191 obo:IAO_0000115 "Pachygyria with cortical thickness greater than 10 mm and an anterior predominant severity gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Anterior predominant gradient indicates pachygyria more severe over the frontal and temporal lobes." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T13:06:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Pachygyria with cortical thickness > 10 mm anterior predominant" ; a owl:Class ; rdfs:label "Anterior predominant thick cortex pachygyria" ; rdfs:subClassOf obo:HP_0020187 . obo:HP_0020192 obo:IAO_0000115 "Pachygyria with a mildly thickend cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age." ; dcterms:creator ; oboInOwl:creation_date "2019-09-03T13:36:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Pachygyria with 5-10 mm cortical thickness" ; rdfs:subClassOf obo:HP_0001302 . obo:HP_0020193 obo:IAO_0000115 "An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T13:57:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Reptilase time may be increased with a deficiency of fibronogen. Unlike the thrombin time, this assay is not affected by the presence of heparin, hirudin, or direct thrombin inhibitors in a blood sample." ; rdfs:label "Prolonged reptilase time" ; rdfs:subClassOf obo:HP_0001928 . obo:HP_0020194 obo:IAO_0000115 "An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:01:38Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "Alpha heavy chain disease" ; a owl:Class ; rdfs:label "IgA heavy chain paraproteinemia" ; rdfs:subClassOf obo:HP_0031049 . obo:HP_0020195 obo:IAO_0000115 "An abnormal IgG heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:04:32Z"^^xsd:dateTime ; oboInOwl:hasRelatedSynonym "Gamma heavy-chain disease" ; a owl:Class ; rdfs:label "IgG heavy chain paraproteinemia" ; rdfs:subClassOf obo:HP_0031049 . obo:HP_0020196 obo:IAO_0000115 "An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:05:43Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "IgM heavy chain paraproteinemia" ; rdfs:subClassOf obo:HP_0031049 . obo:HP_0020197 obo:IAO_0000115 "An increased circulation of arachidonic acid in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:12:41Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Increased circulating arachidonate level", "Increased circulating arachidonic acid level" ; a owl:Class ; rdfs:label "Increased circulating arachidonic acid concentration" ; rdfs:subClassOf obo:HP_0010964 . obo:HP_0020198 obo:IAO_0000115 "Any deviation from the normal concentration of 18-Hydroxycorticosterone level in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:20:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal circulating 18-hydroxycorticosterone level" ; rdfs:subClassOf obo:HP_0012112 . obo:HP_0020199 obo:IAO_0000115 "A subnormal concentration of 18-Hydroxycorticosterone level in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:21:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Decreased circulating 18-hydroxycortisone level" ; rdfs:subClassOf obo:HP_0020198 . obo:HP_0020200 obo:IAO_0000115 "An abnormally elevated concentration of 18-Hydroxycorticosterone level in the blood circulation." ; dcterms:creator ; oboInOwl:creation_date "2019-09-05T14:22:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Increased circulating 18-hydroxycortisone level" ; rdfs:subClassOf obo:HP_0020198 . obo:HP_0020201 obo:IAO_0000115 "Any structural anomaly of the sarcomere, which is unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T15:56:20Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal sarcomere morphology" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0020202 obo:IAO_0000115 "Any structural anomaly of the Z disc, which is the platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T15:57:40Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Z-discs (Z-disk, Z-line, Z-band) delineate the lateral borders of sarcomeres and are the smallest functional units in striated muscle. The core of a Z-disc consists of actin filaments coming from adjacent sarcomeres which are crosslinked by alpha-actinin molecules. Z-discs, which are difficult to detect in conventional light microscopy, appear in the longitudinal view of electron microscopy as electron dense bands with varying sizes, ranging from 30 to 50 nm in fast muscle and 100 t0 140 nm in slow muscle and cardiac myocytes." ; rdfs:label "Abnormal Z disc morphology" ; rdfs:subClassOf obo:HP_0020201 . obo:HP_0020203 obo:IAO_0000115 "Streaming or smearing of the Z band, which is then no longer confined to a narrow zone which bisects the I band. The Z disc may extend across the I band or the entire sarcomere in a zigzag manner. Focal thickening, smudging, and blurring of the Z band takes place concurrently. Myofibrillar disorganization is a frequent but not invariable accompanying change." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T15:58:23Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Z-band streaming" ; rdfs:subClassOf obo:HP_0020202 . obo:HP_0020204 obo:IAO_0000115 "Tubulointerstitial infiltration of bacteria identified on routine and/or special (Brown-Hopps) stains." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T16:29:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Renal tubulointerstitial bacterial organisms" ; a owl:Class ; rdfs:comment "Tubulointerstitial bacteria can be ascending or vascuolcentric/blood-born. This finding can be associated with neutrophil rich infiltrates." ; rdfs:label "Tubulointerstitial bacterial infiltration" ; rdfs:subClassOf obo:HP_0032635 . obo:HP_0020205 obo:IAO_0000115 "Tubulointerstitial infiltration of yeast or hyphal-microrganisms identified on routine and/or special (PAS, silver) stains." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T16:33:20Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Renal tubulointerstitial fungal organisms" ; a owl:Class ; rdfs:comment "Tubulointerstitial fungi be ascending or vascuolcentric/blood-born. This finding can be associated with necrotizing tubulointerstitial lesions." ; rdfs:label "Tubulointerstitial fungal infiltration" ; rdfs:subClassOf obo:HP_0032635 . obo:HP_0020206 obo:IAO_0000115 "The pinna has fewer folds and grooves than usual." ; dcterms:creator ; oboInOwl:creation_date "2019-12-23T20:41:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Simple ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0020207 obo:IAO_0000115 "Seizures precipitated by exogenous stimuli." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:36:35Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Included in 2001 ILAE Proposed Classification of Seizures. Seizures precipitated by fever, head injury, or alcohol withdrawal or anti-epileptic medication withdrawal are not provoked seizures." ; rdfs:label "Reflex seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0020208 obo:IAO_0000115 "A seizure precipitated by aspects of anticipating food, eating itself, or the post-prandial period." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:39:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Eating-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020209 obo:IAO_0000115 "A seizure precipitated by pouring cupfuls of very hot water (40 to 50 degrees Celsius) in rapid succession over the head. Bathing in this manner is the most common trigger." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:40:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Hot water-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020210 obo:IAO_0000115 "A seizure precipitated by complex, cognition-guided tasks often involving visuomotor coordination and decision-making." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:41:45Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Praxis-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020211 obo:IAO_0000115 "A seizure precipitated by movement or a change in posture." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:46:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Proprioceptive-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020212 obo:IAO_0000115 "A seizure precipitated by reading." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:47:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "These are typically manifest by myoclonic movements of the jaw or throat, increasing in frequency and potentially culminating in a bilateral tonic-clonic seizure if reading continues." ; rdfs:label "Reading-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020213 obo:IAO_0000115 "A somatosensory reflex seizure is a seizure precipitated by somatic stimulation of a specific part of the body in the absence of startle or surprise." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:48:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Somatosensory-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020214 obo:IAO_0000115 "Startle-induced seizures are triggered by multiple and non-specific stimuli (auditory, somatosensory, and rarely visual) and are characterized by their sudden unexpected nature. Sudden noise rather than pure sound is the most effective acoustic stimulus." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:51:07Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Seizures are stereotyped and typically unilateral or bilateral tonic in nature." ; rdfs:label "Startle-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020215 obo:IAO_0000115 """Seizures induced by thinking and decision-making. comment:""" ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:53:17Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Cognition induced seizure" ; a owl:Class ; rdfs:comment "These have been reported occurring in response to higher nonverbal mental activity such as playing chess or card games, performing mathematical calculation, drawing complex figures, manipulating spatial information, and typing." ; rdfs:label "Thinking-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020216 obo:IAO_0000115 "Seizures evoked by visual stimuli. This includes clinical seizures induced by strobe lighting, television and other screens, flickering environmental lighting and self-induction by causing a strobe effect." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T13:55:09Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Photosensitive seizure" ; a owl:Class ; rdfs:label "Visually-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0020217 obo:IAO_0000115 "A type of focal motor seizure in which awareness is retained throughout the seizure." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T14:10:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Focal motor aware seizure" ; a owl:Class ; rdfs:label "Focal aware motor seizure" ; rdfs:subClassOf obo:HP_0002349, obo:HP_0011153 . obo:HP_0020218 obo:IAO_0000115 "A type of focal atonic seizure during which awareness is fully retained throughout." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T14:12:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Focal aware atonic seizure" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0020220 . obo:HP_0020219 obo:IAO_0000115 "A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T14:20:36Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "This term describes the initial semiology of the seizure without specifying whether the onset is focal or generalized." ; rdfs:label "Motor seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0020220 obo:IAO_0000115 "A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T14:54:22Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Localised atonic seizure", "Localised hypotonic seizure", "Localized atonic seizure", "Localized hypotonic seizure", "Partial atonic seizure", "Partial hypotonic seizure", "Segmental atonic seizure", "Segmental hypotonic seizure" ; a owl:Class ; rdfs:label "Focal atonic seizure" ; rdfs:subClassOf obo:HP_0010819, obo:HP_0011153 . obo:HP_0020221 obo:IAO_0000115 "A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive." ; dcterms:creator ; oboInOwl:creation_date "2020-02-24T15:50:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "This term describes the initial semiology of the seizure without specifying whether the onset is focal or generalized. Thus it can be used for coding clonic seizures when the onset is not known." ; rdfs:label "Clonic seizure" ; rdfs:subClassOf obo:HP_0020219 . obo:HP_0020222 obo:IAO_0000115 "A decreased concentration of homocystine in the blood." ; dcterms:creator ; oboInOwl:creation_date "2022-10-04T17:59:43Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Hypohomocysteinemia" ; rdfs:subClassOf obo:HP_0010919 . obo:HP_0020223 obo:IAO_0000115 "A dermal sinus tract is an abnormality present at birth over the dorsal midline where an abnormal epithelialized connection from the skin tracks inwards towards the spine, most commonly seen in the lumbosacral region." ; dcterms:creator ; oboInOwl:creation_date "2022-10-04T18:12:37Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The dermal sinus tracks in from the skin and may end in the soft tissues, epidural space, or intradurally, where it is commonly associated with (generally benign) intradural inclusion tumors (including dermoid, epidermoid, or teratoma), thickened fatty filum, tethered cord, or diastematomyelia (split cord syndrome). Dermal sinus tracts are different from innocuous coccygeal dimples, which are located lower within the gluteal cleft and are not associated with cutaneous stigmata; completely 'classic' dimples do not require further workup or follow-up. See Figure 1 of PMID:31484633." ; rdfs:label "Dermal sinus tract" ; rdfs:subClassOf obo:HP_0034238 . obo:HP_0025004 obo:IAO_0000115 "Osteoarthritis of the metatarsophalangeal joint of the first toe." ; dc:date "2016-06-25T09:23:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D020859", "SNOMEDCT_US:6654000", "UMLS:C0264134" ; oboInOwl:hasExactSynonym "Arthritis of the big toe" ; a owl:Class ; rdfs:comment "Hallux rigidus is characterised by arthralgia, which is usually worsened by walking. With time the joint enlarges and the symptoms become more pronounced with pain at the dorsal bony prominence of the first metatarsophalengeal joint (MTPJ) and decreased range of motion, especially dorsiflexion. In this process the destruction of the cartilage commonly starts at the dorsal portion of the metatarsal head and the bony prominence might impinge against the proximal phalanx.. Physical examination usually shows a painful, tender and swollen first MTPJ with limited motion and pain usually when dorsiflexed. Typical radiographic findings are asymmetric joint narrowing and a flattened metatarsal head. With advancement of the disease more of the joint surface is involved and subchondral cysts, sclerosis and bony proliferation at the joint margins occur and the joint narrowing progresses [PMID:24649409]." ; rdfs:label "Hallux rigidus"@en ; rdfs:subClassOf obo:HP_0001844 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007750 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025005 obo:IAO_0000115 "Widening of the wall of capillary blood vessels in the glomerulus. This feature may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself." ; dc:date "2016-08-06T22:31:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thickening of glomerular capillary wall"@en ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0025006 obo:IAO_0000115 "A structural anomaly of the capillary blood vessels in the renal glomerulus." ; dc:date "2016-08-06T22:53:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Abnormalities of the glomerular capillary wall" ; a owl:Class ; rdfs:label "Abnormal glomerular capillary morphology"@en ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0025007 obo:IAO_0000115 "An abnormal anatomic position of the fovea, the small, central pit composed of closely packed cones that is located in the macula of the retina." ; dc:date "2016-08-06T23:07:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Ectopic macula" ; a owl:Class ; rdfs:label "Ectopic fovea"@en ; rdfs:subClassOf obo:HP_0000493 . obo:HP_0025008 obo:IAO_0000115 "Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree." ; dc:date "2016-08-06T23:22:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tracheal tug on inspiration"@en ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0025009 obo:IAO_0000115 "The upper incisors deviate from the normal angle of being roughly parallel to the surface of the face and instead slant outwards." ; dc:date "2016-08-07T12:52:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Forward directed upper incisors", "Proclination of the upper incisors", "Protruding upper incisors" ; a owl:Class ; rdfs:label "Forward slanting upper incisors"@en ; rdfs:subClassOf obo:HP_0011062 . obo:HP_0025010 obo:IAO_0000115 "Partial or complete loss of foveal tissue that was once present." ; dc:date "2016-08-07T13:52:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Loss of foveal tissue (atrophy) may be inferred by a medical history of loss of vision and the observation of a foveal lesion such as reduced foveal thickness on optical coherence tomography (OCT)." ; rdfs:label "Foveal atrophy"@en ; rdfs:subClassOf obo:HP_0000493 . obo:HP_0025011 obo:IAO_0000115 "Narrowing of the anterior nasal aperture (piriform or pyriform aperture), which is a pear-shaped opening in the skull that forms the bony inlet of the nose." ; dc:date "2016-08-07T22:32:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Congenital nasal pyriform aperture stenosis (CNPAS) is a rare cause of nasal airway obstruction that clinically mimics choanal atresia, but needs to be differentiated from the latter because of the widely divergent modes of management [PMID:21423901]." ; rdfs:label "Pyriform aperture stenosis"@en ; rdfs:subClassOf obo:HP_0005105 . obo:HP_0025012 obo:IAO_0000115 "Diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations." ; dc:date "2016-08-07T23:40:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Status cribrosum"@en ; rdfs:subClassOf obo:HP_0002134 . obo:HP_0025013 obo:IAO_0000115 "A type of rigidity that is manifested by an exaggerated extensor posture of all extremities." ; dc:date "2016-08-09T11:43:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decerebrate posturing" ; a owl:Class ; rdfs:comment "Decerebrate rigidity results from release of vestibular nuclei from cerebral control because of a brainstem lesion (i.e., decerebration)." ; rdfs:label "Decerebrate rigidity"@en ; rdfs:subClassOf obo:HP_0002063 . obo:HP_0025014 obo:IAO_0000115 "Small, hard cyst-like nodules, freely moveable in the subcutis over the bony prominences of the legs and arms, which have an outer calcified layer with a translucent core on x-ray." ; dc:date "2016-08-12T11:18:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be observed in individuals with the classic type of Ehlers Danlos syndrome." ; rdfs:label "Subcutaneous spheroids"@en ; rdfs:subClassOf obo:HP_0001482 . obo:HP_0025015 dc:date "2016-08-12T11:24:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vascular morphology"@en ; rdfs:subClassOf obo:HP_0002597, obo:HP_0030680 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007798 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025016 obo:IAO_0000115 "A structural anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues." ; dc:date "2016-08-12T11:42:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal capillary morphology"@en ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025017 obo:IAO_0000115 "Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises)." ; dc:date "2016-08-12T11:50:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The formation of petechiae distal to a tourniquet or sphygmomanometer on release of pressure is known as the Rumpel-Leede sign. This sign was reported in 1909 by Theodor Rumpel, and again independently in 1911 by Carl Stockbridge Leede. Historically, the tourniquet test (or Rumpel-Leede Capillary-Fragility Test) was used to assess patients for thrombocytopenia and capillary fragility. Today, the Rumpel-Leede sign may be observed iatrogenically in the context of continuous blood-pressure monitoring [PMID:24382085]." ; rdfs:label "Capillary fragility"@en ; rdfs:subClassOf obo:HP_0025018 . obo:HP_0025018 obo:IAO_0000115 "A functional anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues." ; dc:date "2016-08-12T11:56:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal capillary physiology"@en ; rdfs:subClassOf obo:HP_0030163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025019 obo:IAO_0000115 "Sudden breakage of an artery leading to leakage of blood from the circulation." ; dc:date "2016-08-12T12:03:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arterial rupture"@en ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0025020 obo:IAO_0000115 "An increased concentration of prostate specific antigen (PSA) in the circulation." ; dc:date "2016-08-12T12:13:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Prostate-specific antigen (PSA) screening for prostate cancer has been common practice although the utility of general PSA screening has been called into question." ; rdfs:label "Elevated prostate-specific antigen level"@en ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0025021 obo:IAO_0000115 "A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling." ; dc:date "2016-08-22T10:26:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal ESR", "Abnormal Westergren sedimentation rate" ; a owl:Class ; rdfs:label "Abnormal erythrocyte sedimentation rate"@en ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0025022 obo:IAO_0000115 "A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling." ; dc:date "2016-08-22T10:39:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased ESR", "Low ESR" ; a owl:Class ; rdfs:label "Decreased erythrocyte sedimentation rate"@en ; rdfs:subClassOf obo:HP_0025021 . obo:HP_0025023 obo:IAO_0000115 "A developmental defect resulting in complete obliteration of the lumen of the rectum. That is, there is an abnormal closure, or atresia of the tubular structure of the rectum." ; dc:date "2016-08-26T11:13:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atresia of the rectum" ; a owl:Class ; rdfs:label "Rectal atresia"@en ; rdfs:subClassOf obo:HP_0002034, obo:HP_0011100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025024 obo:IAO_0000115 "An abnormal dilation of the rectum. There is a large filled rectum as a result of underlying innervation or muscular abnormalities, which remains after disimpaction of the rectum." ; dc:date "2016-08-26T11:18:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Patients with idiopathic megarectum have a dilated rectum but the proximal colon is usually of normal diameter. The condition usually starts in childhood or adolescence, and faecal impaction is common. By contrast, patients with idiopathic megacolon usually do not experience impaction, and the symptoms often begin in adult life [PMID:9301507]." ; rdfs:label "Megarectum"@en ; rdfs:subClassOf obo:HP_0002034 . obo:HP_0025025 obo:IAO_0000115 "A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening." ; dc:date "2016-08-26T11:49:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vestibular fistula" ; a owl:Class ; rdfs:comment "The condition can cause feces and gas to exit the vaginal vestibule." ; rdfs:label "Rectovestibular fistula"@en ; rdfs:subClassOf obo:HP_0100590 . obo:HP_0025026 obo:IAO_0000115 "Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract." ; dc:date "2016-08-26T11:58:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "H-type rectovestibular fistula"@en ; rdfs:subClassOf obo:HP_0025025 . obo:HP_0025027 obo:IAO_0000115 "The term osteoma refers to the anomalous presence of ossification (bone formation) in the interior of the dermis or epidermis. The dermal or subcutaneous bone formation presents as stony hard nodules. The osteomata appear as irregular, hardened small nodules that are well circumscribed and generally of the same color as the skin." ; dc:date "2016-08-26T12:11:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cutaneous osteosis", "Miliary osteoma", "Osteomatosis" ; a owl:Class ; rdfs:label "Osteoma cutis"@en ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0025028 obo:IAO_0000115 "A structural anomaly of nerves of the enteric nervous system." ; dc:date "2016-08-27T11:10:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The enteric nervous system represents a collection of about 500 million neurons that control virtually all gut functions (including motility), largely independent from the central nervous system. The enteric nervous system is located in the gut wall and extends throughout its length from the esophagus to the internal anal sphincter." ; rdfs:label "Abnormality of enteric nervous system morphology"@en ; rdfs:subClassOf obo:HP_0002242, obo:HP_0012331 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002005 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025029 dc:date "2016-08-27T11:22:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of enteric neuron morphology"@en ; rdfs:subClassOf obo:HP_0025028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0007011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025030 obo:IAO_0000115 "Deterioration of enteric neurons with impairment of enteric neuronal structure. Typical neuropathological findings include qualitative (e.g., neuronal swelling, intranuclear inclusions, axonal degeneration) and quantitative (e.g., reduction in the number of neurons) abnormalities of the enteric neurons." ; dc:date "2016-08-27T11:43:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Degenerative enteric neuropathy" ; a owl:Class ; rdfs:label "Enteric neuronal degeneration"@en ; rdfs:subClassOf obo:HP_0025029 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0007011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025031 dc:date "2016-08-27T13:44:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus." ; rdfs:label "Abnormality of the digestive system"@en ; rdfs:subClassOf obo:HP_0000118, obo:HP_0011793 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025032 obo:IAO_0000115 "A functional anomaly of the digestive system." ; dc:date "2016-08-27T13:58:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of digestive system physiology"@en ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025033 obo:IAO_0000115 "A structural anomaly of the digestive system." ; dc:date "2016-08-27T13:58:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of digestive system morphology"@en ; rdfs:subClassOf obo:HP_0025031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025034 obo:IAO_0000115 "Abnormal form of the progenitor cells committed to the erythroid lineage." ; dc:date "2016-09-02T11:14:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of erythroid progenitor cell"@en ; rdfs:subClassOf obo:HP_0012130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000038 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025035 obo:IAO_0000115 "Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." ; dc:date "2016-09-02T11:16:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proerythroblast morphology"@en ; rdfs:subClassOf obo:HP_0012130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000547 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025037 obo:IAO_0000115 "Focal proliferation of glial cells in the hypothalamus." ; dc:date "2016-09-20T10:59:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypothalamic gliosis"@en ; rdfs:subClassOf obo:HP_0002171 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042065 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025038 obo:IAO_0000115 "A collection of pus within a testicle. Ultrasonographic features include shaggy, irregular walls, intratesticular location, low-level internal echoes, and occasionally, hypervascular margins." ; dc:date "2016-09-21T11:02:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Testicular abscess" ; a owl:Class ; rdfs:label "Intratesticular abscess"@en ; rdfs:subClassOf obo:HP_0000035, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025039 obo:IAO_0000115 "Swelling within the basal ganglia due to the accumulation of fluid." ; dc:date "2016-09-25T14:00:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basal ganglia oedema", "Edema of the basal ganglia", "Oedema of the basal ganglia" ; a owl:Class ; rdfs:label "Basal ganglia edema"@en ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025040 obo:IAO_0000115 "Swelling within the thalamus due to the accumulation of fluid." ; dc:date "2016-09-25T14:11:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Edema of the thalamus", "Oedema of the thalamus", "Thalamic oedema" ; a owl:Class ; rdfs:label "Thalamic edema"@en ; rdfs:subClassOf obo:HP_0010663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025041 obo:IAO_0000115 "Calcium deposition in the thalamus." ; dc:date "2016-09-25T14:15:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thalamic calcification"@en ; rdfs:subClassOf obo:HP_0010663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025042 obo:IAO_0000115 "A morphological anomaly of lymph nodes in the mesenteric root or throughout the mesentery." ; dc:date "2016-09-25T14:21:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of mesenteric lymph nodes"@en ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0025043 obo:IAO_0000115 "Increase in size of one or more mesenteric lymph nodes." ; dc:date "2016-09-25T14:26:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mesenteric lymph nodes measured by CT as being larger than 10 mm are considered enlarged." ; rdfs:label "Enlarged mesenteric lymph node"@en ; rdfs:subClassOf obo:HP_0025042 . obo:HP_0025044 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity." ; dc:date "2016-09-25T14:30:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lung abscess"@en ; rdfs:subClassOf obo:HP_0011947, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025045 obo:IAO_0000115 "A deviation from normal of the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-25T16:43:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal lactate level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Abnormal brain lactate level by MRS"@en ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0025046 obo:IAO_0000115 "A decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-25T16:45:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced brain lactate level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Reduced brain lactate level by MRS"@en ; rdfs:subClassOf obo:HP_0025045 . obo:HP_0025047 obo:IAO_0000115 "A deviation from normal in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-25T16:48:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal brain choline level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Abnormal brain choline level by MRS"@en ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0025048 obo:IAO_0000115 "An decrease in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-25T16:49:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced brain choline level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Reduced brain choline level by MRS"@en ; rdfs:subClassOf obo:HP_0025047 . obo:HP_0025049 dc:date "2016-09-26T08:45:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal brain creatine level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:comment "A deviation from normal in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS)." ; rdfs:label "Abnormal brain creatine level by MRS"@en ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0025050 obo:IAO_0000115 "An increase in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-26T08:46:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated brain creatine level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Elevated brain creatine level by MRS"@en ; rdfs:subClassOf obo:HP_0025049 . obo:HP_0025051 obo:IAO_0000115 "A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-26T08:48:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low brain creatine phosphate", "Reduced brain creatine level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Reduced brain creatine level by MRS"@en ; rdfs:subClassOf obo:HP_0025049 . obo:HP_0025052 obo:IAO_0000115 "A deviation from normal in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-26T08:50:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal brain N-acetyl aspartate level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Abnormal brain N-acetyl aspartate level by MRS"@en ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0025053 obo:IAO_0000115 "An increase in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2016-09-26T08:52:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated brain N-acetyl aspartate level by magnetic resonance spectroscopy" ; a owl:Class ; rdfs:label "Elevated brain N-acetyl aspartate level by MRS"@en ; rdfs:subClassOf obo:HP_0025052 . obo:HP_0025057 obo:IAO_0000115 "A structural anomaly of the olfactory lobe, the structure within the brain that receives neural input from the nasal cavity and thereby processes the sense of smell." ; dc:date "2016-09-26T09:03:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of olfactory lobe morphology"@en ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005366 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025058 obo:IAO_0000115 "Partial or complete wasting (loss) of hypothalamus tissue that was once present." ; dc:date "2016-09-26T09:07:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atrophy of the hypothalamus" ; a owl:Class ; rdfs:label "Hypothalamic atrophy"@en ; rdfs:subClassOf obo:HP_0012286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025059 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the parenchyma of the spleen." ; dc:date "2016-09-26T09:11:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Splenic abscesses generally occur in patients with neoplasia, immunodeficiency, trauma, metastatic infection, splenic infarct or diabetes." ; rdfs:label "Splenic abscess"@en ; rdfs:subClassOf obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025060 obo:IAO_0000115 "Multiple abscess lesions in the spleen." ; dc:date "2016-09-26T09:19:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multilocular splenic abscess" ; a owl:Class ; rdfs:label "Multifocal splenic abscess"@en ; rdfs:subClassOf obo:HP_0025059 . obo:HP_0025061 obo:IAO_0000115 "Single (solitary) abscess in the spleen." ; dc:date "2016-09-26T09:21:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Solitary splenic abscess", "Unilocular splenic abscess" ; a owl:Class ; rdfs:label "Unifocal splenic abscess"@en ; rdfs:subClassOf obo:HP_0025059 . obo:HP_0025062 obo:IAO_0000115 "The practice of eating earth or soil-like substrates such as clay or chalk." ; dc:date "2016-09-26T09:47:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Geophagy" ; a owl:Class ; rdfs:label "Geophagia"@en ; rdfs:subClassOf obo:HP_0011856 . obo:HP_0025063 obo:IAO_0000115 "The anterior abdominal wall is sunken and presents a concave rather than a convex contour." ; dc:date "2016-09-26T09:54:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Scaphoid abdomen can be observed in diseases such as congenital diaphragmatic hernia (since the abdominal contents can be in the thorax)." ; rdfs:label "Scaphoid abdomen"@en ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0025064 obo:IAO_0000115 "Bleeding in the thalamus." ; dc:date "2016-09-26T10:03:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thalamic haemorrhage" ; a owl:Class ; rdfs:comment "Thalamic hemorrhage may be observed in individuals with hypertension. In both the acute and chronic phases of bleeding, prominent susceptibility effect, seen as hypointense blooming on sequences, is typically seen upon magnetic resonance imaging." ; rdfs:label "Thalamic hemorrhage"@en ; rdfs:subClassOf obo:HP_0010663 . obo:HP_0025065 obo:IAO_0000115 "A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters." ; dc:date "2016-09-26T10:08:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal MCV", "Abnormal erythrocyte volume" ; a owl:Class ; rdfs:label "Abnormal mean corpuscular volume"@en ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0025066 obo:IAO_0000115 "A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters)." ; dc:date "2016-09-26T10:10:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased MCV", "Microcytosis", "Reduced erythrocyte volume" ; a owl:Class ; rdfs:label "Decreased mean corpuscular volume"@en ; rdfs:subClassOf obo:HP_0025065 . obo:HP_0025068 obo:IAO_0000115 "Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort." ; dc:date "2016-09-26T10:25:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Incomitant strabismus"@en ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0025069 obo:IAO_0000115 "Strabismus in which the angle of deviation of the squiting eye remains the same in relation to the other eye, in all directions of gaze, and whichever eye is fixing." ; dc:date "2016-09-26T10:29:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Comitant strabismus" ; a owl:Class ; rdfs:label "Concomitant strabismus"@en ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0025070 obo:IAO_0000115 "An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3." ; dc:date "2016-09-26T10:36:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "U waves represent prolonged repolarisation of myocardial M cells. Under normal conditions the M cells are electrically coupled to adjacent cell layers. However, in conditions that produce electrical uncoupling, these M cells have significant effects on repolarisation producing prolonged rounded ST-T waves or U waves. The finding of U wave inversion on an ECG at rest or baseline is a non-specific finding. It is significant when observed post exercise, being originally described in early 1940s. Subsequent studies in the late 1970s, demonstrated a significant correlation of U wave inversion with either left main or LAD disease." ; rdfs:label "Abnormal U wave"@en ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0025071 obo:IAO_0000115 "Direction of the U wave opposite to the T wave (i.e., below baseline) in leads with upright T waves." ; dc:date "2016-09-26T10:39:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Inverted U wave may be a sign of coronary artery disease, hypertension, valvular heart disease, congenital heart disease, cardiomyopathy, or hyperthyroidism. In individuals with acute chest pain, it may be a sign of myocardial ischemia." ; rdfs:label "U wave inversion"@en ; rdfs:subClassOf obo:HP_0025070 . obo:HP_0025072 obo:IAO_0000115 "Increased amplitude of the U wave, defined as an amplitude grerater than 1-2mm or 25 percent of the height of the T wave." ; dc:date "2016-09-26T10:42:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased U wave amplitude" ; a owl:Class ; rdfs:label "Prominent U wave"@en ; rdfs:subClassOf obo:HP_0025070 . obo:HP_0025073 obo:IAO_0000115 "U wave inversion that is induced by exercise stress testing." ; dc:date "2016-09-26T10:44:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exercise-induced U wave inversion"@en ; rdfs:subClassOf obo:HP_0025071 . obo:HP_0025074 obo:IAO_0000115 "An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram." ; dc:date "2016-09-26T10:46:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal QRS complex"@en ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0025075 obo:IAO_0000115 "Elevation of the voltage (height) of the QRS complex. There are several criteria in use, but the most common is the Sokolov-Lyon criterion (S wave depth in V1 + tallest R wave height in V5-V6 greater than 35 mm)." ; dc:date "2016-09-26T10:48:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased QRS voltage"@en ; rdfs:subClassOf obo:HP_0025076 . obo:HP_0025076 obo:IAO_0000115 "Abnormal amplitude of the QRS complex of the electrocardiogram (EKG)." ; dc:date "2016-09-26T10:50:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal QRS voltage"@en ; rdfs:subClassOf obo:HP_0025074 . obo:HP_0025077 obo:IAO_0000115 "Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm." ; dc:date "2016-09-26T10:50:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased QRS voltage"@en ; rdfs:subClassOf obo:HP_0025076 . obo:HP_0025078 obo:IAO_0000115 "The QRS complexes of the electrocardiogram alternate in height." ; dc:date "2016-09-26T10:52:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Electrical alternans"@en ; rdfs:subClassOf obo:HP_0025076 . obo:HP_0025079 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the parenchyma of the pancreas." ; dc:date "2016-09-26T11:01:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pancreas abscess" ; a owl:Class ; rdfs:label "Pancreatic abscess"@en ; rdfs:subClassOf obo:HP_0012090, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025080 obo:IAO_0000115 "A form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei." ; dc:date "2016-10-12T23:40:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyperkeratosis is most commonly orthokeratotic." ; rdfs:label "Orthokeratotic hyperkeratosis"@en ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0025081 obo:IAO_0000115 "A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP." ; dc:date "2016-10-12T23:46:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Darier's sign"@en ; rdfs:subClassOf obo:HP_0001025 . obo:HP_0025082 obo:IAO_0000115 "Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils." ; dc:date "2016-10-15T12:16:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cutaneous elastic fibre morphology" ; a owl:Class ; rdfs:comment "Elastic fibers help the skin return to its normal configuration after being stretched or deformed. The elastic fibers consist of two components: microfibrils and matrix elastin. The microfibrillar component amounts to only 15% of the elastic fiber, whereas the amorphous, electron-lucid elastin makes up 85% of the fiber. In light microscope sections that are routinely stained, elastic fibers are inconspicuous. With special elastic tissue stains, such as orcein or resorcin-fuchisin, or in plastic-embedded sections they are found entwined among the collagen bundles [PMID:21738362]." ; rdfs:label "Abnormal cutaneous elastic fiber morphology"@en ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0025083 obo:IAO_0000115 "An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin." ; dc:date "2016-10-15T13:13:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Disorders of elastosis may show an increased content of desmosines, whereas elastolytic disorders may show a reduced content of desmosine." ; rdfs:label "Elevated dermal desmosine content"@en ; rdfs:subClassOf obo:HP_0034924 . obo:HP_0025084 obo:IAO_0000115 "Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule." ; dc:date "2016-10-15T13:35:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Follicular pustule" ; a owl:Class ; rdfs:comment "In contrast to folliculitis, perifolliculitis refers to inflammatory cells, usually lymphocytes, within the perifollicular tissues with focal extension into the adjacent reticular dermis. Folliculitis and perifolliculitis can occur independently or incombination owing to follicular disruption and irritation." ; rdfs:label "Folliculitis"@en ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0025085 obo:IAO_0000115 "Passage of many stools containing blood." ; dc:date "2016-10-15T13:58:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Blood in stool", "Bloody stool" ; oboInOwl:hasExactSynonym "Bloody bowel movement", "Bloody diarrhea", "Bloody diarrhoea" ; a owl:Class ; rdfs:comment "Diarrhea that contains bright red or maroon-colored blood may be referred to as hematochezia, while melena is used to describe black, tarry, and smelly diarrhea." ; rdfs:label "Bloody diarrhea"@en ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0025086 obo:IAO_0000115 "Passage of many stools containing blood and mucus." ; dc:date "2016-10-15T13:59:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bloody mucoid diarrhoea" ; a owl:Class ; rdfs:label "Bloody mucoid diarrhea"@en ; rdfs:subClassOf obo:HP_0025085 . obo:HP_0025087 obo:IAO_0000115 "Area of skin requiring an increased amount of time to return to its original shape after being stretched." ; dc:date "2016-10-15T14:50:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "see PMID:23919031" ; rdfs:label "Delayed recoil upon stretching of skin"@en ; rdfs:subClassOf obo:HP_0008067 . obo:HP_0025088 obo:IAO_0000115 "Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth." ; dc:date "2016-10-24T00:35:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Onychomadesis is defined as proximal nail plate separation from the nail matrix and nail bed caused by a temporary arrest in nail matrix activity, and may present as a Beau's line." ; rdfs:label "Onychomadesis"@en ; rdfs:subClassOf obo:HP_0001806 . obo:HP_0025089 obo:IAO_0000115 "Vomiting of material that is of fecal origin." ; dc:date "2016-10-24T00:38:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Faecal vomiting", "Fecal vomiting", "Stercoraceous vomiting", "Vomiting faecal matter", "Vomiting fecal matter" ; a owl:Class ; rdfs:comment "Feculent vomiting is usually due to mechanical intestinal obstruction but it can be due to paralytic obstruction (adynamic ileus)." ; rdfs:label "Feculent vomiting"@en ; rdfs:subClassOf obo:HP_0002013 . obo:HP_0025090 obo:IAO_0000115 "A structural anomaly of the mucous lining of the large intestine." ; dc:date "2016-10-24T00:55:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal large intestinal mucosa morphology"@en ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0025092 obo:IAO_0000115 "Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin)." ; dc:date "2016-10-24T01:14:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acanthosis", "Acanthotic epidermis", "Thickening of upper layer of skin" ; oboInOwl:hasRelatedSynonym "Epidermal hyperplasia" ; a owl:Class ; rdfs:comment "Note that we use the prefered label 'Epidermal acanthocytosis' to distinguish this term from acanthocytosis of red blood cells." ; rdfs:label "Epidermal acanthosis"@en ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0025093 obo:IAO_0000115 "A retinal exudate in the area surrounding the optic nerve head." ; dc:date "2016-10-24T01:19:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peripapillary exudation" ; a owl:Class ; rdfs:label "Peripapillary exudate"@en ; rdfs:subClassOf obo:HP_0001147 . obo:HP_0025094 obo:IAO_0000115 "A subretinal scar with a disc-like shape in the region of the macula." ; dc:date "2016-10-24T01:29:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disciform macular scar"@en ; rdfs:subClassOf obo:HP_0200056 . obo:HP_0025095 obo:IAO_0000115 "A sudden violent, spasmodic, audible expiration of breath through the nose and mouth." ; dc:date "2016-10-24T01:36:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sneeze"@en ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0025096 obo:IAO_0000115 "Unprovoked explosive pathological sneezing." ; dc:date "2016-10-24T01:37:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paroxysmal sneezing"@en ; rdfs:subClassOf obo:HP_0025095 . obo:HP_0025097 obo:IAO_0000115 "Marked, involuntary jerking of the eyelids." ; dc:date "2016-10-28T05:55:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blepharoclonus" ; oboInOwl:hasRelatedSynonym "Eyelid myoclonia" ; a owl:Class ; rdfs:comment "Some literature refers to eyelid myoclonia as a disease entity (Jeavons syndrome) that is characterized by episodes of eyelid myoclonus with absences." ; rdfs:label "Eyelid myoclonus"@en ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0025098 obo:IAO_0000115 "Structural abnormality of the hypothalamus related to defective development." ; dc:date "2016-10-28T06:41:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypothalamic dysgenesis" ; a owl:Class ; rdfs:comment "Note that the term hypothalamic dysgenesis is generally used to refer to a morphological abnormality of the hypothalamus that is of presumed developmental (rather than acquired) origin." ; rdfs:label "Dysgenesis of the hypothalamus"@en ; rdfs:subClassOf obo:HP_0012286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001898 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025099 obo:IAO_0000115 "Structural abnormality of the thalamus related to defective development." ; dc:date "2016-10-28T06:51:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thalamic dysgenesis" ; a owl:Class ; rdfs:comment "Note that the term thalamic dysgenesis is generally used to refer to a morphological abnormality of the thalamus that is of presumed developmental (rather than acquired) origin." ; rdfs:label "Dysgenesis of the thalamus"@en ; rdfs:subClassOf obo:HP_0010663 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004703 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025100 obo:IAO_0000115 "Any structural anomaly of the hippocampus," ; dc:date "2016-10-28T07:12:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal morphology of the hippocampus", "Abnormality of hippocampus morphology" ; a owl:Class ; rdfs:comment "The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." ; rdfs:label "Abnormal hippocampus morphology"@en ; rdfs:subClassOf obo:HP_0007343 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025101 obo:IAO_0000115 "Structural abnormality of the hippocampus related to defective development." ; dc:date "2016-10-28T07:15:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hippocampal dysgenesis" ; a owl:Class ; rdfs:comment "Note that the term hippocampal dysgenesis is generally used to refer to a morphological abnormality of the hippocampus that is of presumed developmental (rather than acquired) origin." ; rdfs:label "Dysgenesis of the hippocampus"@en ; rdfs:subClassOf obo:HP_0025100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025102 obo:IAO_0000115 "Structural abnormality of the basal ganglia related to defective development." ; dc:date "2016-10-28T07:21:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basal ganglia dysgenesis" ; a owl:Class ; rdfs:comment "Note that the term basal ganglia dysgenesis is generally used to refer to a morphological abnormality of the basal ganglia that is of presumed developmental (rather than acquired) origin." ; rdfs:label "Dysgenesis of the basal ganglia"@en ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002420 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025103 obo:IAO_0000115 "A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated)." ; dc:date "2016-10-28T07:30:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Umbilicated nodule"@en ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0025104 obo:IAO_0000115 "A capillary malformation is a flat, sharply defined vascular stain of the skin. It may cover a large surface area or it may be scattered and appear as little islands of color. In a capillary maformation, the predominant vessels are small, slow-flow vessels (i.e., arterioles and postcapillary venules)." ; dc:date "2016-10-28T23:39:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are many different classifications, and some authors treat the term capillary malformation as being synonymous with port wine stain (nevus flammeus). We refer to the detailed classification of Happle (PMID:25864701), which we do not completely follow." ; rdfs:label "Capillary malformation"@en ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0025105 obo:IAO_0000115 "A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anaemic spots." ; dc:date "2016-10-28T23:49:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Naevus anaemicus" ; a owl:Class ; rdfs:label "Nevus anemicus"@en ; rdfs:subClassOf obo:HP_0025104 . obo:HP_0025106 obo:IAO_0000115 "A variant of port-wine stain characterized by a pale red or even pink tone, in contrast to the darker hue of the port-wine stain. By analogy with the term port-wine stain, this variant rose-wine stain, or nevus roseus. Nevus roseus, however, cannot be definitely diagnosed until adulthood as port-wine stains are sometimes pink in children. While the natural history of port-wine stains includes hypertrophy, darkening, and nodularity, nevus roseus remains unchanged for life." ; dc:date "2016-10-28T23:53:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nevus roseus"@en ; rdfs:subClassOf obo:HP_0025104 . obo:HP_0025107 obo:IAO_0000115 "A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible." ; dc:date "2016-10-29T00:22:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cutis marmorata telangiectatica congenita"@en ; rdfs:subClassOf obo:HP_0025104 . obo:HP_0025108 obo:IAO_0000115 "Angioma serpiginosum consists of punctate, tightly packed telangiectatic lesions. Characteristic histopathological features are dilated and tortuous capillaries involving the uppermost part of the dermis." ; dc:date "2016-10-29T00:31:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment """Two different forms can be distinguished. Diffuse, non-segmental angioma serpiginosum occurs as a hereditary trait, and autosomal dominant transmission is presently assumed.""" ; rdfs:label "Angioma serpentinum"@en ; rdfs:subClassOf obo:HP_0025104 . obo:HP_0025109 obo:IAO_0000115 "Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." ; dc:date "2016-10-29T00:37:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced erythrocyte pyruvate kinase activity" ; a owl:Class ; rdfs:label "Reduced red cell pyruvate kinase level"@en ; rdfs:subClassOf obo:HP_0030272 . obo:HP_0025110 obo:IAO_0000115 "Yellow/white, sharply delineated lesion, typically of inflammatory nature, involving the macula." ; dc:date "2016-11-01T01:20:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Placoid macular lesion"@en ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0025112 obo:IAO_0000115 "Decreased tolerance to sound." ; dc:date "2016-11-01T01:30:30Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Noise sensitivity" ; a owl:Class ; rdfs:comment "Sound sensitivity impliees a difficulty tolerating sounds which do not seem loud or unpleasant to others." ; rdfs:label "Auditory sensitivity" ; rdfs:subClassOf obo:HP_5200058 . obo:HP_0025113 obo:IAO_0000115 "An adverse response (dislike) to sound no matter what volume the sound is, characterized by a strong negative reaction to soft sounds that can sometimes be further triggered by seeing the source of the offending sound." ; dc:date "2016-11-01T01:33:52Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Misophonia" ; rdfs:subClassOf obo:HP_5200060 . obo:HP_0025114 obo:IAO_0000115 "Hypergranulosis is an increased thickness of the stratum granulosum." ; dc:date "2016-11-01T01:48:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Note that the epidermis includes five main layers: the stratum corneum, stratum lucidium, stratum granulosum, stratum spinosum, and stratum germinativum. This term refers to thickening that primarily affects the stratum granulosum." ; rdfs:label "Hypergranulosis"@en ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0025115 obo:IAO_0000115 "Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant" ; dc:date "2016-11-01T01:58:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Colloid bodies", "Colloid bodies of Civatte", "Cytoid bodies", "Hyaline bodies" ; a owl:Class ; rdfs:comment "The presence of numerous civatte bodies (CBs) in biopsies is a characteristic finding in skin lesions of patients with various dermatoses, particularly lichen planus (LP) and discoid lupus erythematosus (DLE). Achille Civatte (1877-1956) was a French dermatologist." ; rdfs:label "Civatte bodies"@en ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0025116 obo:IAO_0000115 "An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile." ; dc:date "2016-11-01T10:13:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Foetal distress" ; a owl:Class ; rdfs:comment "Fetal distress in itself is a non-specific term as the various parameters characterizing the type and degree of distress are themselves ill defined. Nonethless the term is in broad clinical use and thus is included as an HPO term. It is preferable to annotate with more precise terms if possible." ; rdfs:label "Fetal distress"@en ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0025117 obo:IAO_0000115 "Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance." ; dc:date "2016-11-01T10:52:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flattened rete pegs", "Flattened rete ridges" ; a owl:Class ; rdfs:label "Rete ridge flattening"@en ; rdfs:subClassOf obo:HP_0034767 . obo:HP_0025118 obo:IAO_0000115 "Lightening or darkening of the lips from their usual coloring." ; dc:date "2016-11-01T11:25:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lip discoloration"@en ; rdfs:subClassOf obo:HP_0032453 . obo:HP_0025119 obo:IAO_0000115 "An alteration of the color of the lip to take on a violet color. This term does not include cyanosis." ; dc:date "2016-11-01T11:25:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature may be seen rarely as a paraneoplastic manifestation." ; rdfs:label "Violet lip discoloration"@en ; rdfs:subClassOf obo:HP_0025118 . obo:HP_0025121 obo:IAO_0100001 "HP:0011165" ; dc:date "2016-11-10T11:43:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Simple partial occipital seizures is being retired because the clinical manifestations used for seizure classification do not hold true to anatomical landmarks at this level of granularity. An additional dimension based on the anatomical onset of seizures would be too imprecise, and in many instances be incorrect. Whilst clinicians do still talk about a frontal/occipital/temporal/etc. lobe seizure, this is based on assumptions, typical features, or additional EEG or imaging findings." ; rdfs:label "obsolete Simple partial occipital seizures"@en ; owl:deprecated true . obo:HP_0025122 obo:IAO_0000115 "A type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis." ; dc:date "2016-11-14T01:39:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sawtoothed acanthosis" ; a owl:Class ; rdfs:label "Sawtooth acanthosis"@en ; rdfs:subClassOf obo:HP_0025092 . obo:HP_0025123 obo:IAO_0000115 "Areas of white discoloration visible on the surface of the teeth (enamel) in the form of streaks or specks." ; dc:date "2016-11-14T01:47:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "White streaks/specks on enamel."@en ; rdfs:subClassOf obo:HP_0011073 . obo:HP_0025124 obo:IAO_0000115 "A tendency of teeth to fracture as manifested by a history of repeated fracture of the dental enamel without adequate trauma." ; dc:date "2016-11-14T01:53:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Enamel with tendency to chip", "Spontaneous tooth fracture" ; a owl:Class ; rdfs:label "Fragile teeth"@en ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0025125 obo:IAO_0000115 "White lesions of the oral mucosa are generally caused by a condition that increases the thickness of the epithelium. This increases the distance to the vascular bed and thereby tends to change the usual reddish color of the oral mucosa to white. Common causes include hyperkeratosis (thickening of the keratin layer), acanthosis (thickening of the spinous cell layer), increased edema in the epithelium (leukoedema), and reduced vascularity of the underlying lamina propria. Additionally, fibrin caps or surface ulcerations and collapsed bullae can appear white." ; dc:date "2016-11-14T02:08:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "White lesion of the oral mucosa"@en ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0025126 obo:IAO_0000115 "A corrugated white lesion of the oral mucosa that usually occurs on the lateral or ventral surfaces of the tongue and may have a shaggy or frayed appearance." ; dc:date "2016-11-14T02:15:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oral hairy leukoplakia"@en ; rdfs:subClassOf obo:HP_0025125 . obo:HP_0025127 obo:IAO_0000115 "A scaly, crusty lesion caused by damage from the ultraviolet radiation of the sun, with typical location on sun-exposed areas of the skin. Actinic keratosis lesions are often elevated, rough, and wartlike, and may be red, or occasionally tan, pink, or flesh-toned in color." ; dc:date "2016-11-14T02:23:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Solar keratosis" ; a owl:Class ; rdfs:comment "Up to ten percent of untreated actinic keratoses develop into squamous cell carcinoma of the skin." ; rdfs:label "Actinic keratosis"@en ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0025128 obo:IAO_0000115 "An abnormally reduced amount of adipose tissue in the abdominal cavity." ; dc:date "2016-11-14T02:33:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced intraabdominal adipose tissue"@en ; rdfs:subClassOf obo:HP_0040063 . obo:HP_0025129 obo:IAO_0000115 "A structural anomaly of the mucous lining of the small intestine." ; dc:date "2016-11-15T11:57:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal small intestinal mucosa morphology"@en ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0025130 obo:IAO_0000115 "Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges." ; dc:date "2016-11-15T12:01:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lactase deficiency" ; a owl:Class ; rdfs:label "Decreased small intestinal mucosa lactase level"@en ; rdfs:subClassOf obo:HP_0012379, obo:HP_0025129 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001204 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0000016 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025131 obo:IAO_0000115 "Enlargement of the soft tissues of one or more fingers." ; dc:date "2016-11-15T12:08:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Swelling of fingers", "Swollen finger", "Swollen fingers" ; a owl:Class ; rdfs:label "Finger swelling"@en ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0025132 obo:IAO_0000115 "A deviation from normal concentration of the hormone estrogen in the blood circulation." ; dc:date "2016-11-27T13:46:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating oestrogen level", "Abnormal estrogen level", "Abnormal oestrogen level" ; a owl:Class ; rdfs:comment "Clinical estrogen tests measure one of three components: estrone (E1), estradiol (E2), or estriol (E3)." ; rdfs:label "Abnormal circulating estrogen level"@en ; rdfs:subClassOf obo:HP_0033799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50114 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025133 obo:IAO_0000115 "A deviation from normal concentrations of estradiol in the circulation." ; dc:date "2016-11-27T13:52:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Estradiol is the most biologically prevalent and active compound of a class of steroids called estrogens" ; rdfs:label "Abnormal serum estradiol"@en ; rdfs:subClassOf obo:HP_0025132 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23965 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025134 obo:IAO_0000115 "An elevation above normal limits of the concentration of estradiol in the circulation." ; dc:date "2016-11-27T14:09:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased estradiol level", "Increased serum oestradiol" ; a owl:Class ; rdfs:label "Increased serum estradiol"@en ; rdfs:subClassOf obo:HP_0025133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23965 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025135 obo:IAO_0000115 "A deviation from normal concentration of estriol in the circulation." ; dc:date "2016-11-27T14:10:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal serum estriol"@en ; rdfs:subClassOf obo:HP_0025132 . obo:HP_0025136 obo:IAO_0000115 "An elevation above normal limits of estriol concentration in the circulation." ; dc:date "2016-11-27T14:13:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased serum estriol"@en ; rdfs:subClassOf obo:HP_0025135 . obo:HP_0025137 obo:IAO_0000115 "A reduction below normal limits of estriol in the circulation." ; dc:date "2016-11-27T14:13:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased serum estriol"@en ; rdfs:subClassOf obo:HP_0025135 . obo:HP_0025138 obo:IAO_0000115 "A deviation from the normal concentration of circulating estrone." ; dc:date "2016-11-27T14:14:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal serum estrone"@en ; rdfs:subClassOf obo:HP_0025132 . obo:HP_0025139 obo:IAO_0000115 "An elevation above normal limits of the concentration of estrone in the circulation." ; dc:date "2016-11-27T14:15:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased serum estrone"@en ; rdfs:subClassOf obo:HP_0025138 . obo:HP_0025140 obo:IAO_0000115 "A reduction below normal limits of the concentration of estrone in the circulation." ; dc:date "2016-11-27T14:15:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased serum estrone"@en ; rdfs:subClassOf obo:HP_0025138 . obo:HP_0025141 obo:IAO_0000115 "Ectopic deposition of calcium salts found in the gingiva." ; dc:date "2016-11-27T14:27:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gingival calcifications" ; a owl:Class ; rdfs:label "Gingival calcification"@en ; rdfs:subClassOf obo:HP_0000168, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001828 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025142 obo:IAO_0000115 "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual." ; dc:date "2016-11-29T11:02:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Note that we use the preferred term label constitutional symptom because this reflects common usage, but we do not restrict the term or its descendents to the narrow meaning of symptom, i.e., a complaint related by a patient to a physician. There is no generally accepted classification of what defines a constitutional symptom, but examples include weight loss, fatigue, general weakness, night sweats, shaking, chills, fever, and vomiting." ; rdfs:label "Constitutional symptom"@en ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0025143 obo:IAO_0000115 "A sudden sensation of feeling cold." ; dc:date "2016-11-29T11:10:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chills" ; a owl:Class ; rdfs:comment "The word chills can also refer to an episode of shivering, accompanied by paleness and feeling cold." ; rdfs:label "Chills"@en ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0025144 obo:IAO_0000115 "Involuntary contraction or twitching of the muscles." ; dc:date "2016-11-29T11:13:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Shivering", "Shuddering" ; a owl:Class ; rdfs:comment "Shivering is a physiologic method of heat production in man and other mammals. Shivering is a bodily function in response to fever, early hypothermia or feeling cold." ; rdfs:label "Shivering"@en ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0025145 obo:IAO_0000115 "Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever." ; dc:date "2016-11-29T11:15:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Rigours" ; a owl:Class ; rdfs:comment "A sudden attack of severe shivering accompanied by chills (a feeling of coldness) is called a rigor and may be associated with a marked rise in body temperature. Patients often describe rigors as an attack of uncontrollable shaking. Rigors are often a sign of infection, particularly bacterial infection." ; rdfs:label "Rigors"@en ; rdfs:subClassOf obo:HP_0025143, obo:HP_0025144 . obo:HP_0025146 obo:IAO_0000115 "Deterioration of the tissue of the fovea, i.e.,the region of sharpest vision within the macula of the retina." ; dc:date "2016-11-29T11:24:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Foveal degeneration"@en ; rdfs:subClassOf obo:HP_0000493, obo:HP_0000608 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001786 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025147 obo:IAO_0000115 "A shiny appearance of the macula, which is often called a beaten bronze appearance." ; dc:date "2016-11-29T11:37:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Beaten metal macular appearance", "Beaten-bronze macular appearance", "Beaten-bronze macular sheen" ; a owl:Class ; rdfs:comment "This feature may be seen in Stargardt disease." ; rdfs:label "Beaten bronze macular sheen"@en ; rdfs:subClassOf obo:HP_0008002 . obo:HP_0025148 obo:IAO_0000115 "A fluorescein angiographic finding of absence of the normal background fluorescence (a dark choroid)." ; dc:date "2016-11-29T11:49:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The cause of dark choroid is thought to relate to the deposition of an abnormal material (lipofuscin) in the retinal pigment epithelial cells." ; rdfs:label "Dark choroid"@en ; rdfs:subClassOf obo:HP_0000610 . obo:HP_0025149 obo:IAO_0000115 "Partial or complete wasting (loss) of muscularois propria tissue that was once present. The atrophy may involve a marked vacuolar degeneration of myocytes, loss of muscle fibers and some cases a highly characteristic honeycomb fibrosis." ; dc:date "2016-12-03T14:04:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Autonomic visceral myopathy", "Degenerative enteric myopathy" ; a owl:Class ; rdfs:label "Atrophic muscularis propria"@en ; rdfs:subClassOf obo:HP_0030935 . obo:HP_0025150 obo:IAO_0000115 "Sparse and small myenteric ganglia" ; dc:date "2016-12-03T14:28:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Enteric ganglia are the nerve cell clusters (groups of nerve cell bodies) that are involved in mediating the muscular activity of the intestines." ; rdfs:label "Hypoganglionosis"@en ; rdfs:subClassOf obo:HP_0004362 . obo:HP_0025151 obo:IAO_0000115 "Hyperplastic submucosal and myenteric plexus containing an increased number of ganglion cells, glial cells and nerve fibers." ; dc:date "2016-12-03T14:36:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ganglioneuromatosis"@en ; rdfs:subClassOf obo:HP_0004362 . obo:HP_0025152 obo:IAO_0000115 "Lack of visual responsiveness or decrease in visual capabilities suggesting a lack of visual responsiveness or decrease in visual capabilities in an infant or young child in which visual behavior fails to meet normal developmental milestones." ; dc:date "2016-12-03T21:34:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal visual behavior for age", "Abnormal visual behaviour for age", "Poor visual behaviour for age" ; a owl:Class ; rdfs:comment "A failure to meet age-related milestones in areas such as (i) focusing ability, (ii) eye coordinationg and tracking of objects in the visual field, (iii) depth perception, (iv) color perception, and (v) object and face recognition. These milestones are generally met in the first three months of life, and failure to meet them may indicate abnormal visual development or function." ; rdfs:label "Poor visual behavior for age"@en ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0025153 obo:IAO_0000115 "Short-lived and not permanent. This term applies to a phenotypic abnormality that is temporary and of short duration." ; dc:date "2016-12-03T22:19:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transient"@en ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0025154 obo:IAO_0000115 "Presence of biliary veins that serve as a collateral channel to the systemic circulation" ; dc:date "2016-12-03T22:24:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Collateral biliary circulation", "Collateral biliary veins" ; a owl:Class ; rdfs:comment "Venous blood returning from the small intestine, stomach, pancreas and spleen converges into the portal vein. The terminal branches of the hepatic portal vein and hepatic artery empty together and mix as they enter sinusoids in the liver. Conditions such as liver cirrhosis, in which scar tissue partially blocks the normal flow of blood, may increases the pressure in the portal vein (portal hypertension).When blood flow through a vessel or a vascular bed is obstructed due to occlusion, collateral pathways open up as blood bypasses the occlusion or obstruction, and this can lead to portosystemic collateral veins in the case of cirrhosis and some other hepatobiliary diseases." ; rdfs:label "Portosystemic collateral veins"@en ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0025155 obo:IAO_0000115 "A functional anomaly of the hepatobiliary system" ; dc:date "2016-12-04T12:05:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of hepatobiliary system physiology"@en ; rdfs:subClassOf obo:HP_0025032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025156 obo:IAO_0000115 "Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status." ; dc:date "2016-12-04T12:14:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dependency on IV nutrition" ; a owl:Class ; rdfs:comment "Total parenteral nutrition (TPN) refers to the application of an intravenous nutritional solution in individuals with gastrointestinal disorders that prevent them from absorbing a sufficient amount of nutrients from the gut to maintain health. The solution contains protein, carbohydrates (in the form of glucose), glucose, fat, vitamins, and minerals. Dependency on TPN is essentially a manifestation of the continued severity of a gastrointestinal disorder." ; rdfs:label "Dependency on intravenous nutrition"@en ; rdfs:subClassOf obo:HP_0025032 . obo:HP_0025157 obo:IAO_0000115 "An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group." ; dc:date "2016-12-04T12:36:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary sedoheptulose"@en ; rdfs:subClassOf obo:HP_0031979 . obo:HP_0025158 obo:IAO_0000115 "Increased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging." ; dc:date "2016-12-04T12:53:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperautofluorescent retinal lesion"@en ; rdfs:subClassOf obo:HP_0030602 . obo:HP_0025159 obo:IAO_0000115 "Decreased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging." ; dc:date "2016-12-04T12:54:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypo-autofluorescent retinal lesion" ; a owl:Class ; rdfs:label "Hypoautofluorescent retinal lesion"@en ; rdfs:subClassOf obo:HP_0030602 . obo:HP_0025160 obo:IAO_0000115 "A temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual." ; dc:date "2016-12-04T12:59:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal temper tantrums"@en ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0025161 obo:IAO_0000115 "Temper tantrums that occur more frequently than usual." ; dc:date "2016-12-04T13:05:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Frequent temper tantrums"@en ; rdfs:subClassOf obo:HP_0025160 . obo:HP_0025162 obo:IAO_0000115 "Temper tantrums whose severity is more severe than usual. For instance, a temper tantrum might be considered to be severe if a child loses control so completely that the child cannot control the tantrum on its own, continuing until it becomes exhausted or a parent intervenes." ; dc:date "2016-12-04T13:05:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe temper tantrums"@en ; rdfs:subClassOf obo:HP_0025160 . obo:HP_0025163 obo:IAO_0000115 "A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves." ; dc:date "2016-12-04T13:12:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of optic chiasm morphology"@en ; rdfs:subClassOf obo:HP_0000587 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000959 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025164 obo:IAO_0000115 "An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods." ; dc:date "2016-12-04T13:43:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased number of elastic fibres in the dermis" ; a owl:Class ; rdfs:label "Increased number of elastic fibers in the dermis"@en ; rdfs:subClassOf obo:HP_0025082 . obo:HP_0025165 obo:IAO_0000115 "Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis)." ; dc:date "2016-12-04T13:50:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clumping of elastic fibres in the dermis" ; a owl:Class ; rdfs:label "Clumping of elastic fibers in the dermis"@en ; rdfs:subClassOf obo:HP_0025082 . obo:HP_0025166 obo:IAO_0000115 "An increase of the diameter of elastic fibers in the dermis." ; dc:date "2016-12-04T13:54:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thickened elastic fibres in the dermis" ; a owl:Class ; rdfs:label "Thickened elastic fibers in the dermis"@en ; rdfs:subClassOf obo:HP_0025082 . obo:HP_0025167 obo:IAO_0000115 "Elastic fibers in the dermis exhibit an increased number of breaks associated with disorganization of the structure of the elastic fibers." ; dc:date "2016-12-04T13:56:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fragmented elastic fibres in the dermis" ; a owl:Class ; rdfs:label "Fragmented elastic fibers in the dermis"@en ; rdfs:subClassOf obo:HP_0025082 . obo:HP_0025168 obo:IAO_0000115 "Abnormal function of the left ventricule during left ventricular relaxation and filling." ; dc:date "2016-12-04T14:01:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Diastolic left ventricular disease can cause of limitation of exercise tolerance, whether or not ejection fraction is normal. This feature can be assessed by cardiac imaging." ; rdfs:label "Left ventricular diastolic dysfunction"@en ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0025169 obo:IAO_0000115 "Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent." ; dc:date "2016-12-04T14:07:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Left ventricular systolic dysfunction"@en ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0025170 obo:IAO_0000115 "A central nervous system neoplasm with neuronal and, less consistently, glial differentiation." ; dc:date "2016-12-04T14:30:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glioneuronal tumor", "Glioneuronal tumour", "Neuronal and mixed neuronal-glial tumor", "Neuronal and mixed neuronal-glial tumour", "Neuronal/glioneuronal neoplasm of the CNS" ; a owl:Class ; rdfs:label "Neuronal/glioneuronal neoplasm of the central nervous system"@en ; rdfs:subClassOf obo:HP_0030063, obo:HP_0100006 . obo:HP_0025171 obo:IAO_0000115 "A tumor of the central nervous system that has components of both neurocytic and glial areas, whereby usually the glial component of the tumor predominates. Rossette-forming glioneuronal tumors (RGNT) have biphasic cytoarchitecture with two elements; neurocytic rosettes resembling Homer-Wright rosettes, and astrocytic component resembling a pilocytic astrocytoma. RGNTs are low-grade tumors that lack histopathological signs of malignancy." ; dc:date "2016-12-04T14:35:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Rosette-forming glioneuronal neoplasm", "Rosette-forming glioneuronal tumour" ; oboInOwl:hasRelatedSynonym "Rosette-forming glioneuronal tumor of the fourth ventricle", "Rosette-forming glioneuronal tumour of the fourth ventricle" ; a owl:Class ; rdfs:label "Rosette-forming glioneuronal tumor"@en ; rdfs:subClassOf obo:HP_0025170 . obo:HP_0025172 obo:IAO_0000115 "Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a smooth appearance of the interlobular septa." ; dc:date "2016-12-04T19:28:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Smooth septal thickening on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0030879 . obo:HP_0025173 obo:IAO_0000115 "Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a nodular or beaded appearance of the interlobular septa." ; dc:date "2016-12-04T19:30:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nodular septal thickening on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0030879 . obo:HP_0025174 obo:IAO_0000115 "Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with an irregular appearance of the interlobular septa. THis feature is often associated with distortion of lung architecture." ; dc:date "2016-12-04T19:31:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Irregular septal thickening on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0030879 . obo:HP_0025175 obo:IAO_0000115 "Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care." ; dc:date "2016-12-04T19:34:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Honeycomb cysts", "Honeycombing" ; a owl:Class ; rdfs:comment "Pathologically, honeycombing is manifested as small air-containing cystic spaces that are lined by bronchiolar epithelium and have thickened walls of dense fibrous tissue. On high-resolution CT, honeycombing presents with a characteristic cystic appearance. The cystic spaces range from 3 mm to 1 cm in diameter, although they can be larger. The cystic spaces are characterized by well delineated walls 1 to 3 mm in thickness. The cysts are air-filled and appear lucent in comparison to normal lung parenchyma. Honeycombing is a manifestation of end-stage lung fibrosis." ; rdfs:label "Honeycomb lung"@en ; rdfs:subClassOf obo:HP_0005948, obo:HP_0006530 . obo:HP_0025176 obo:IAO_0000115 "A fine reticular pattern on high-resolution computed tomography, with the visible lines separated by a few millimeters. Regions of the lung with intralobular interstitial thickening characteristically show a fine lacelike or netlike appearance." ; dc:date "2016-12-04T19:39:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intralobular interstitial thickening"@en ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0025177 obo:IAO_0000115 "Thickening of the peribronchovascular interstitium, a connective tissue sheath that surrounds the central bronchi and pulmonary arteries. The peribronchovascular interstitium extends from the level of the pulmonary hila into the peripheral lung. This feature may be ascertained on high-resolution computer tomography." ; dc:date "2016-12-04T19:41:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peribronchovascular interstitial thickening"@en ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0025178 obo:IAO_0000115 "Increase in thickness of the subpleural interstitium." ; dc:date "2016-12-04T19:44:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Subpleural scarring" ; a owl:Class ; rdfs:comment "Subpleural interstitial thickening can be difficult to recognize where the lung contacts the chest wall or mediastinum but is easy to delineate adjacent to the major fissure. Thickening of the fissure visible on high-resolution computer tomography may represent subpleural interstitial thickening." ; rdfs:label "Subpleural interstitial thickening"@en ; rdfs:subClassOf obo:HP_0031630 . obo:HP_0025179 obo:IAO_0000115 """On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.""" ; dc:date "2016-12-04T19:55:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "GGO", "Ground glass opacities" ; oboInOwl:hasNarrowSynonym "Ground-glass opacification on pulmonary HRCT" ; a owl:Class ; rdfs:comment "Ground-glass opacification is a non-specific sign and can be observed with many conditions including infection, chronic interstitial disease and acute alveolar disease. See Figure 2 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Ground-glass opacification"@en ; rdfs:subClassOf obo:HP_0031457 . obo:HP_0025180 obo:IAO_0000115 "A hazy area of increased attenuation in centrilobular areas of the lung with preserved bronchial and vascular markings seen on a computer tomography scan. Centrilobular refers to a location that is central within secondary pulmonary lobules." ; dc:date "2016-12-04T19:57:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Centrilobular groundglass opacification", "Centrilobular groundglass opacity" ; a owl:Class ; rdfs:label "Centrilobular ground-glass opacification on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025179 . obo:HP_0025181 obo:IAO_0000115 "An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently." ; dc:date "2016-12-04T20:11:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abdominal aseptic abscess"@en ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0025182 obo:IAO_0000115 "A confined region of lax skin that hangs below the level of the surrounding skin. Histopatholigically, there is a loss of elastic fibers in the dermis of the affected region." ; dc:date "2016-12-04T21:29:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Localised area of pendulous skin" ; a owl:Class ; rdfs:label "Localized area of pendulous skin"@en ; rdfs:subClassOf obo:HP_0008067 . obo:HP_0025186 obo:IAO_0000115 "Unilateral ptosis with associated upper eyelid contraction and contraction of either the external or the internal pterygoid muscle. It is thought to occur because of congenital miswiring of a branch of the fifth cranial nerve into the branch of the third cranial nerve supplying the levator muscle. In Marcus Gunn jaw winking synkinesis, elevation and even retraction of the affected eyelid is triggered by chewing, suction, lateral mandible movement, smiling, sternocleidomastoid contraction, protruding tongue, Valsalva manoeuvre and even by breathing." ; dc:date "2016-12-04T22:17:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Marcus Gunn jaw-winking syndrome", "Pterygoid-levator synkinesis", "Trigemino-oculomotor synkinesis" ; a owl:Class ; rdfs:label "Marcus Gunn jaw winking synkinesis"@en ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0025188 obo:IAO_0000115 "Inflammation of retinal blood vessels as manifested by perivascular sheathing or cuffing, vascular leakage and/or occlusion." ; dc:date "2016-12-04T22:37:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term refers to the appearance of the retinal vessels on fundoscopy or other investigations. Retinal vasculitis may be associated with other manifestations such as visual impairment." ; rdfs:label "Retinal vasculitis"@en ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0025190 obo:IAO_0000115 "A bilateral tonic-clonic seizure with generalized onset is a type of bilateral tonic-clonic seizure characterised by generalized onset; these seizures rapidly engage networks in both hemispheres at the start of the seizure." ; dc:date "2016-12-04T22:50:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bilateral tonic-clonic seizure with generalised onset", "Generalised tonic-clonic seizure without focal onset", "Generalised tonic-clonic seizure without partial onset", "Generalised tonic-clonic seizures without focal onset", "Generalised-onset tonic-clonic seizure", "Generalized tonic-clonic seizure without focal onset", "Generalized tonic-clonic seizure without partial onset", "Generalized tonic-clonic seizures without focal onset", "Generalized-onset tonic-clonic seizure", "Primarily generalised tonic-clonic seizures", "Primarily generalized tonic-clonic seizures", "Primary generalised tonic-clonic seizure", "Primary generalised tonic-clonic seizures", "Primary generalized tonic-clonic seizure", "Primary generalized tonic-clonic seizures" ; a owl:Class ; rdfs:label "Bilateral tonic-clonic seizure with generalized onset"@en ; rdfs:subClassOf obo:HP_0002069, obo:HP_0032677 . obo:HP_0025191 obo:IAO_0100001 "HP:0011166" ; dc:date "2016-12-04T23:02:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Segmental myoclonic seizures"@en ; owl:deprecated true . obo:HP_0025192 obo:IAO_0000115 "Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the fourth cerebral ventricle (which is located beneath the tentorium of the cerebellum)." ; dc:date "2016-12-04T23:09:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subtentorial periventricular white matter hyperdensity"@en ; rdfs:subClassOf obo:HP_0030891 . obo:HP_0025193 obo:IAO_0000115 "A posterolateral defect in the diaphragm, commonly referred to as a Bochdalek hernia, which is often accompanied by herniation of the stomach, intestines, liver, and/or spleen into the chest cavity." ; dc:date "2016-12-05T01:51:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bochdalek hernia" ; a owl:Class ; rdfs:label "Posterolateral diaphragmatic hernia"@en ; rdfs:subClassOf obo:HP_0000776 . obo:HP_0025194 obo:IAO_0000115 "An anterior retrosternal or parasternal hernia that can result in the herniation of liver or intestines into the chest cavity." ; dc:date "2016-12-05T01:55:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Morgagni hernia" ; a owl:Class ; rdfs:comment "Morgagni hernias are generally accompanied by a hernia sac, and often do not cause symptoms in the newborn period." ; rdfs:label "Morgagni diaphragmatic hernia"@en ; rdfs:subClassOf obo:HP_0000776 . obo:HP_0025195 obo:IAO_0000115 "A congenital diaphragm defect involving the central tendinous (e.g., amuscular) portion of the diaphragm, whereby the entire rim of diaphragmatic musculature is present." ; dc:date "2016-12-05T01:57:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Central hernia" ; a owl:Class ; rdfs:label "Central diaphragmatic hernia"@en ; rdfs:subClassOf obo:HP_0000776 . obo:HP_0025196 obo:IAO_0000115 "An elevation in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. A high TIBC corresponds to a high transferrin concentration. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity." ; dc:date "2016-12-05T02:10:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Iron is transported to body tissues by a protein, transferrin, in plasma. This protein has two high-affinity binding sites for iron. Determination of total iron-binding capacity (TIBC) of the plasma therefore gives a measure of transferrin, although it can also be directly determined. Virtually all plasma iron (P1) normally is bound to transferrin, and measurement of P1 is assumed to reflect the amount of transferrin iron. The expression transferrin saturation, expressed as percent [(P1/TIBC) x 100], indicates the availability of iron to tissues. As transferrin saturation increases, there is an increase in the amount of diferric transferrin, which has a greater capacity to deliver iron than does monoferric transferrin. Measurements of P1, TIBC, and transferrin saturation have served several purposes in clinical medicine. The P1 concentration and (particularly) transferrin saturation relect the adequacy of iron supply. A saturation of less than 16% indicates a deficient iron supply, whereas a saturation of over 60% as measured on more than one occasion represents excessive iron loading owing to increased iron absorption or liver disease. An increased transferrmn concentration as reflected in the TIBC indicates iron depletion if the effects of estrogen and pregnancyare excluded. Other characteristic changes inboth P1 and TIBC are useful in the differential diagnosis of various diseases, for example, the decrease in transferrin saturations associated with a decreased transferrin concentration in inflammatory states." ; rdfs:label "Increased total iron binding capacity"@en ; rdfs:subClassOf obo:HP_0033212 . obo:HP_0025197 obo:IAO_0000115 "A benign tumor made up of mostly myofibroblasts that appears almost exclusively on the digits of the hands and feet, rarely involving the thumb or big toe. The lesion displays a proliferation of bland intradermal spindle cells arranged in whorls, fascicles, or a storiform pattern in a collagenous background of varying degrees. Also usually present are perpendicular tumor cell fascicles that extend to the epidermis. The small intracytoplasmic inclusions are said to appear similar to red blood cells. The inclusion bodies have been shown to be made up of densely packed vimentin and actin filaments. The tumor often causes a dome-shaped elevation of the overlying structures, forming a protuberant or polypoid nodule. The overlying epidermis can display a host of changes, including acanthosis, hyperkeratosis, parakeratosis, rete ridge flattening, entrapment of adnexal structures, and, rarely, ulceration." ; dc:date "2016-12-05T11:28:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Digital fibrous tumor of Reye", "Digital fibrous tumour of Reye", "Infantile digital fibroma", "Infantile digital fibromatosis" ; a owl:Class ; rdfs:label "Inclusion body fibromatosis"@en ; rdfs:subClassOf obo:HP_0012316 . obo:HP_0025198 obo:IAO_0000115 "A non-malignant sessile or pedunculated polyp in the colon and rectum that displays a cap of inflammatory granulation tissue with fibrinopurulent exudate that covers the polyp." ; dc:date "2016-12-05T11:49:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The condition inflammatory cap polyposis is characterized by the presence of multiple inflammatory cap polyps in the large intestine." ; rdfs:label "Inflammatory cap polyp"@en ; rdfs:subClassOf obo:HP_0005266 . obo:HP_0025200 obo:IAO_0000115 "Accumulation in muscle cells of filaments composed of actin." ; dc:date "2016-12-06T03:05:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle fibre actin filament accumulation" ; a owl:Class ; rdfs:label "Muscle fiber actin filament accumulation"@en ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0025201 obo:IAO_0000115 "A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation." ; dc:date "2016-12-10T12:53:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal apolipoprotein level" ; a owl:Class ; rdfs:label "Abnormal circulating apolipoprotein concentration"@en ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0025202 obo:IAO_0000115 "An increased concentration in blood of apolipoprotein A-IV, a major component of HDL and chylomicrons that has a role in VLDL secretion and catabolism and is required for efficient activation of lipoprotein lipase by ApoC-II." ; dc:date "2016-12-10T12:56:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated apolipoprotein A-IV level" ; a owl:Class ; rdfs:label "Elevated circulating apolipoprotein A-IV concentration"@en ; rdfs:subClassOf obo:HP_0033460 . obo:HP_0025203 obo:IAO_0000115 "Distended and engorged umbilical veins which are seen radiating from the umbilicus across the abdomen to join systemic veins." ; dc:date "2016-12-10T13:11:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Palm tree sign" ; a owl:Class ; rdfs:comment "Caput medusae is a sign of severe portal hypertension with portal-systemic shunting through the umbilical veins. The name refers to Medusa's hair once Minerva had turned it into snakes. Caput Medusae can be distinguished from inferior vena cava obstruction by determining the direction of flow in the veins below the umbilicus; it is towards the legs in caput medusae, and towards the head with inferior vena cava obstruction. See figure 2 in PMID: 29089832." ; rdfs:label "Caput medusae"@en ; rdfs:subClassOf obo:HP_0030168 . obo:HP_0025204 obo:IAO_0000115 "A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation." ; dc:date "2016-12-10T13:33:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by"@en ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0025205 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by breast feeding in an infant." ; dc:date "2016-12-10T13:41:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Breastfeeding triggered symptoms", "Triggered by breastfeeding" ; a owl:Class ; rdfs:label "Triggered by breast feeding"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025206 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to cold surroundings." ; dc:date "2016-12-10T13:44:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cold triggered symptoms", "Triggered by cold temperature" ; a owl:Class ; rdfs:label "Triggered by cold"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025207 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by being dehydrated, i.e., by a deficit in total body water." ; dc:date "2016-12-10T13:45:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dehydration triggered symptoms", "Triggered by dehydration" ; a owl:Class ; rdfs:label "Triggered by dehydration"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025208 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking carbohydrates." ; dc:date "2016-12-10T13:46:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Carbohydrate ingestion triggered symptoms", "Triggered by carbohydrate ingestion" ; a owl:Class ; rdfs:label "Triggered by carbohydrate ingestion"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025209 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking fructose." ; dc:date "2016-12-10T13:48:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trigged by fruit sugar" ; a owl:Class ; rdfs:label "Triggered by fructose ingestion"@en ; rdfs:subClassOf obo:HP_0025208 . obo:HP_0025210 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking glucose." ; dc:date "2016-12-10T13:48:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by glucose ingestion"@en ; rdfs:subClassOf obo:HP_0025208 . obo:HP_0025211 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by drinking or otherwise ingesting ethanol." ; dc:date "2016-12-10T13:50:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Triggered by alcohol ingestion" ; oboInOwl:hasExactSynonym "Ethanol ingestion triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by ethanol ingestion"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025212 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by abstaining from eating food (fasting)." ; dc:date "2016-12-10T13:50:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fasting triggered attacks", "Fasting triggered symptoms", "Triggered by fasting" ; a owl:Class ; rdfs:label "Triggered by fasting"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025213 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking galactose. Galactose usually is ingested as lactose, which is composed of equimolar amounts of glucose and galactose." ; dc:date "2016-12-10T13:51:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Triggered by ingestion of lactose-containing milk" ; a owl:Class ; rdfs:label "Triggered by galactose ingestion"@en ; rdfs:subClassOf obo:HP_0025208 . obo:HP_0025214 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to heat." ; dc:date "2016-12-10T13:59:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heat triggered symptoms", "Triggered by heat" ; a owl:Class ; rdfs:label "Triggered by heat"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025215 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by febrile illness." ; dc:date "2016-12-10T14:00:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Febrile illness triggered symptoms", "Triggered by fever" ; a owl:Class ; rdfs:label "Triggered by febrile illness"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025216 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating large quantities of food, for instance, by a heavy meal." ; dc:date "2016-12-10T14:01:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heavy meal triggered symptoms", "Triggered by overeating" ; a owl:Class ; rdfs:label "Triggered by heavy meal"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025217 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating a diet high in lipids." ; dc:date "2016-12-10T14:02:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High-fat diet triggered symptoms", "Triggered by high-fat diet" ; a owl:Class ; rdfs:label "Triggered by high-fat diet"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025218 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by excessively rapid and deep breathing." ; dc:date "2016-12-10T14:02:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperventilation triggered symptoms", "Triggered by hyperventilation" ; a owl:Class ; rdfs:label "Triggered by hyperventilation"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025219 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a vaccination." ; dc:date "2016-12-10T14:04:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Triggered by immunisation", "Triggered by immunization", "Triggered by vaccination", "Vaccination triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by vaccination"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025220 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by menstruation in a female." ; dc:date "2016-12-10T14:05:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Menstruation triggered symptoms", "Triggered by monthly period", "Triggered by period" ; a owl:Class ; rdfs:label "Triggered by menstruation"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025221 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by pregnancy in a female." ; dc:date "2016-12-10T14:06:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pregnancy triggered symptoms", "Triggered by pregnancy" ; a owl:Class ; rdfs:label "Triggered by pregnancy"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025222 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a lack of sufficient sleep." ; dc:date "2016-12-10T14:07:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sleep deprivation triggered symptoms", "Triggered by sleep deprivation" ; a owl:Class ; rdfs:label "Triggered by sleep deprivation"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025223 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by smoking." ; dc:date "2016-12-10T14:07:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Smoking triggered symptoms", "Triggered by cigarette consumption", "Triggered by smoking", "Triggered by tobacco use" ; a owl:Class ; rdfs:label "Triggered by smoking"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025224 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking sodium." ; dc:date "2016-12-10T14:08:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sodium ingestion triggered symptoms", "Sodium intake triggered attacks", "Triggered by Na ingestion", "Triggered by Na+ ingestion", "Triggered by sodium intake" ; oboInOwl:hasNarrowSynonym "Triggered by salt ingestion" ; a owl:Class ; rdfs:label "Triggered by sodium ingestion"@en ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0025225 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to sound or noise." ; dc:date "2016-12-10T14:09:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sound triggered symptoms", "Triggered by sound" ; a owl:Class ; rdfs:comment "For instance, seizures associated with autosomal dominant partial epilepsy with auditory features may be triggered by certain sounds such as telephone ringing or speech." ; rdfs:label "Triggered by sound"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025226 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a physical, mental, or emotional factor associated with bodily or mental tension." ; dc:date "2016-12-10T14:24:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stress triggered symptoms", "Triggered by stress" ; a owl:Class ; rdfs:label "Triggered by stress"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025227 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a a state of excitement or by being startled." ; dc:date "2016-12-10T14:28:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Excitement triggered symptoms", "Triggered by excitement" ; oboInOwl:hasRelatedSynonym "Triggered by startle" ; a owl:Class ; rdfs:label "Triggered by excitement"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025228 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a sudden movement." ; dc:date "2016-12-10T14:29:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Kinesigenic", "Sudden movement triggered symptoms", "Triggered by sudden movement" ; a owl:Class ; rdfs:label "Triggered by sudden movement"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025229 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by vestibular stimulation, including head turning, cold calorics, postural changes, or rotating chair." ; dc:date "2016-12-10T14:30:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vestibular stimulation triggered attacks", "Vestibular stimulation triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by vestibular stimulation"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025230 obo:IAO_0000115 "Inflammation of a tendon." ; dc:date "2016-12-14T11:20:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Teninitis" ; a owl:Class ; rdfs:label "Tendonitis"@en ; rdfs:subClassOf obo:HP_0100261 . obo:HP_0025231 obo:IAO_0000115 "A structural anomaly of a synovial bursa." ; dc:date "2016-12-14T11:29:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of synovial bursa morphology" ; a owl:Class ; rdfs:comment "A synovial bursa is a small fluid-filled saclike cavity that facilitates the gliding of muscles or tendons over bony or ligamentous surfaces. There are numerous synovial bursae in the body, for instance at the shoulder, elbow, knee, and hip." ; rdfs:label "Abnormal synovial bursa morphology"@en ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0025232 obo:IAO_0000115 "Inflammation of a synovial bursa." ; dc:date "2016-12-14T11:33:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bursitis"@en ; rdfs:subClassOf obo:HP_0025231 . obo:HP_0025233 obo:IAO_0000115 "An inability to move the body at sleep onset or upon awakening from sleep lasting seconds to a few minutes." ; dc:date "2016-12-14T11:44:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sleep paralysis"@en ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0025234 obo:IAO_0000115 "An undesirable physical event or experience that occurs during entry into sleep, during sleep, or during arousal from sleep." ; dc:date "2016-12-14T11:50:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Parasomnia"@en ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0025235 obo:IAO_0000115 "A parasomnia that occurs in non-rapid eye movement (NREM) sleep. This refers to a disorder of arousal that occurs during slow-wave sleep (ie, NREM stage 3 sleep)." ; dc:date "2016-12-14T11:55:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "NREM parasomnia" ; a owl:Class ; rdfs:comment """NREM parasomnias usually occur within a few hours after sleep onset, episodes last from a few minutes to as long as 30-40 min, and are characterised by amnesia for the event.""" ; rdfs:label "Non-rapid eye movement parasomnia"@en ; rdfs:subClassOf obo:HP_0025234 . obo:HP_0025236 obo:IAO_0000115 "Ambulation or other complex motor behaviors after getting out of bed in a sleep-like state. During sleepwalking episodes, the sonambulating individual appears confused or dazed, the eyes are usually open, and he or she might mumble or give inappropriate answers to questions, or occasionally appear agitated." ; dc:date "2016-12-14T12:01:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sleep walking" ; a owl:Class ; rdfs:comment "During an episode of sleepwalking, the sonambulating child typically appears clumsy and might perform unusual actions such as urinating in a closet. Injuries can occur during sleepwalking, including falling downstairs or after leaving the house." ; rdfs:label "Somnambulism"@en ; rdfs:subClassOf obo:HP_0025235 . obo:HP_0025237 obo:IAO_0000115 "A nocturnal episode characterized by disorientation, grogginess, and, at times, substantial agitation upon awakening from slow-wave sleep or following forced awakenings. These characteristics might present as agitation, crying or moaning, disorientation, and particularly slow mentation on arousal from sleep (i.e., sleep inertia). The duration of episodes is typically 5 to 15 min but they might last up to several hours." ; dc:date "2016-12-14T12:07:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Confusional arousal"@en ; rdfs:subClassOf obo:HP_0025235 . obo:HP_0025238 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the foot." ; dc:date "2016-12-16T11:55:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Foot pain" ; a owl:Class ; rdfs:label "Foot pain"@en ; rdfs:subClassOf obo:HP_0012514 . obo:HP_0025239 obo:IAO_0000115 "A localized detachment of the vitreous from the retina due to the accumulation of blood. When localized in the macular area, it results in sudden profound loss of vision. Subhyaloid premacular hemorrhage is typically characterized by a circumscribed, round or dumb-bell shaped, bright red mound of blood beneath the internal limiting membrane (ILM) or between the ILM and hyaloid face, in or near to the central macular area." ; dc:date "2016-12-17T00:34:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Subhyaloid haemorrhage", "Subhyaloid heme" ; a owl:Class ; rdfs:comment "Clinically speaking, distinguishing between preretinal and subhyaloid hemorrhages is difficult. Therefore, clinicians use the terms inter-changeably. A D-shaped or boat-shaped appearance may be observed, because the blood accumulates within loosely adherent tissue of the superficial retina and can spread and settle inferiorly with gravity. A sharp demarcation line is usually evident." ; rdfs:label "Subhyaloid hemorrhage"@en ; rdfs:subClassOf obo:HP_0025240 . obo:HP_0025240 obo:IAO_0000115 "An accumulation of blood between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation." ; dc:date "2016-12-17T00:54:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Preretinal haemorrhage", "Preretinal heme" ; a owl:Class ; rdfs:comment "Clinically speaking, distinguishing between preretinal and subhyaloid hemorrhages is difficult. Therefore, clinicians often use the terms interchangeably. A D-shaped or boat-shaped appearance may be observed, because the blood accumulates within loosely adherent tissue of the superficial retina and can spread and settle inferiorly with gravity. A sharp demarcation line is usually evident." ; rdfs:label "Preretinal hemorrhage"@en ; rdfs:subClassOf obo:HP_0031803 . obo:HP_0025241 obo:IAO_0000115 "A type of retinal hemorrhage that is located within the nerve fiber layer (NFL) of the retina and that exhibits a characteristic flame shape which results from constraints by the structure of the NFL (axons of the ganglion cells)." ; dc:date "2016-12-17T01:14:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Feathered retinal heme", "Flame-shaped retinal haemorrhage", "Linear retina heme" ; a owl:Class ; rdfs:comment "Flame-shaped hemorrhages are typically located in the posterior pole and tend to resolve within around six weeks. THeir pathophysiology is thought to reflect ischemic leakage from arterioles or veins that are ischemic or, in the case of veins, under high pressure." ; rdfs:label "Flame-shaped retinal hemorrhage"@en ; rdfs:subClassOf obo:HP_0031805 . obo:HP_0025242 obo:IAO_0000115 "Accumulation of blood located in the retina's inner nuclear and outer plexiform layers, and having a dot-like or blot-like shape. THe shape results from intraretinal compression, restricting the hemorrhages within a specific location." ; dc:date "2016-12-17T01:25:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dot-and-blot retinal haemorrhage", "Round retinal heme" ; a owl:Class ; rdfs:comment "Dot-ant-blot Intraretinal hemorrhages take longer to resolve than superficial hemorrhages because they're deeper than flame-shaped hemorrhages." ; rdfs:label "Dot-and-blot retinal hemorrhage"@en ; rdfs:subClassOf obo:HP_0031805 . obo:HP_0025243 obo:IAO_0000115 "Accumulation of blood located beneath the neurosensory retina in the space between the neurosensory retina and the retinal pigment epithelium." ; dc:date "2016-12-17T01:29:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Subretinal haemorrhage", "Subretinal heme" ; a owl:Class ; rdfs:comment "Subretinal hemorrhages are located deep in the retina, displaying a dark coloration with the retinal vessels clearly visible above. Subretinal hemorrhages tend not to be well delineated because of the lack of firm attachments between the neurosensory retina and the retinal pigment epithelium, allowing the blood to spread." ; rdfs:label "Subretinal hemorrhage"@en ; rdfs:subClassOf obo:HP_0000573 . obo:HP_0025244 obo:IAO_0000115 "An accumulation of blood located between the retinal pigment epithelium (RPE) and Bruch's membrane." ; dc:date "2016-12-17T01:39:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Subretinal pigment epithelium haemorrhage" ; a owl:Class ; rdfs:label "Subretinal pigment epithelium hemorrhage"@en ; rdfs:subClassOf obo:HP_0000573 . obo:HP_0025245 obo:IAO_0000115 "A hollow mass located in the skin that is surrounded by an epithelium-lined wall and is well demarcated from the adjacent tissue. Cysts are often said to be sac-like and may contain serous liquid or semisolid material." ; dc:date "2016-12-17T13:11:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to cysts, vesicles, pustules and bullae do not have a complete epithelial lining and are therefore less well demarcated." ; rdfs:label "Cutaneous cyst"@en ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0025246 obo:IAO_0000115 "Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Trichilemmal cysts are acquired rather than congenital, and tend to appear on the scalp rather than the face, and to be intradermal rather than subcutaneous." ; dc:date "2016-12-17T13:45:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pilar cyst" ; a owl:Class ; rdfs:comment "Epidermal cysts and trichilemmal cysts are clinically indistinguishable. The wall of the epidermal cyst conserves the epidermal layers, but the wall of the trichilemmal cysts, which arise from the external root sheath, shows palisading of unlayered epithelial cells. Homogeneous horny material that is further degraded to fat and cholesterol forms within both types of cysts." ; rdfs:label "Trichilemmal cyst"@en ; rdfs:subClassOf obo:HP_0025245 . obo:HP_0025247 obo:IAO_0000115 """A congenital subcutaneous cyst that arises from entrapment of skin along the lines of embryonic fusion. In contrast to epidermal cysts, dermoid cysts tend to contain various adnexal structures such as hair, sebaceous, eccrine or apocrine glands. Dermoid cysts are present at birth, and are indolent, firm, deep, subcutaneous nodules. They are often located on the head and neck, and rarely in the anogenital area. Dermoid cysts are slowly progressive and can grow to a size of 1 to 4 cm.""" ; dc:date "2016-12-17T13:49:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dermoid cyst"@en ; rdfs:subClassOf obo:HP_0025245 . obo:HP_0025248 obo:IAO_0000115 "A cutaneous cyst that is small (one or two millimeters in diameter) and painless, presenting as a follicular papule that usually is skin colored but may have a reddish or brownish tinge." ; dc:date "2016-12-17T13:52:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Eruptive vellus hair cysts result from occlusion and cystic dilation of vellus hair follicles." ; rdfs:label "Eruptive vellus hair cyst"@en ; rdfs:subClassOf obo:HP_0025245 . obo:HP_0025249 obo:IAO_0000115 "A clogged cutaneous sebaceous follicle, which is a cutaneous gland that secretes sebum (usually into a hair follicle)." ; dc:date "2016-12-17T13:56:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Comedo"@en ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0025250 obo:IAO_0000115 "A comedo in which the top of the pore is not stretched open and thus does not expose the clogged portion (which would appear black), hence the name whitehead." ; dc:date "2016-12-17T13:57:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Whitehead" ; a owl:Class ; rdfs:label "Closed comedo"@en ; rdfs:subClassOf obo:HP_0025249 . obo:HP_0025251 obo:IAO_0000115 "A comedo in which the part of the pore at the surface of the skin is stretched and open, exposing the contents of the comedo, which appear black." ; dc:date "2016-12-17T14:04:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blackhead" ; a owl:Class ; rdfs:label "Open comedo"@en ; rdfs:subClassOf obo:HP_0025249 . obo:HP_0025252 obo:IAO_0000115 "An anomaly of the tongue characterized by loss (atrophy) of filiform papillae of the tongue, leaving areas of erythema (redness), surrounded by a serpiginous, white, hyperkeratotic border. The name geographic tongue refers to an appearance that is said to be similar to a map." ; dc:date "2016-12-17T14:09:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Annulus migrans", "Benign migratory glossitis", "Glossitis areata exfoliativa", "Lingual erythema migrans", "Wandering rash of the tongue" ; a owl:Class ; rdfs:label "Geographic tongue"@en ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0025253 obo:IAO_0000115 "An abnormal fear of being in a closed or narrow space with no escape." ; dc:date "2016-12-17T14:14:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Claustrophobia"@en ; rdfs:subClassOf obo:HP_0100852 . obo:HP_0025254 obo:IAO_0000115 "An ameliorating factor is defined as an external factor that leads to a sign or symptom that is already present improving or becoming more bearable" ; dc:date "2016-12-17T14:17:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Improved by" ; a owl:Class ; rdfs:label "Ameliorated by"@en ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0025255 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by pregnancy in a female." ; dc:date "2016-12-17T14:19:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pregnancy relieves symptoms" ; a owl:Class ; rdfs:label "Ameliorated by pregnancy"@en ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0025256 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by heat (including fever)." ; dc:date "2016-12-17T14:20:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heat improves condition", "Heat improves symptom" ; oboInOwl:hasNarrowSynonym "Fever improves condition" ; a owl:Class ; rdfs:label "Ameliorated by heat"@en ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0025257 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by eating or drinking carbohydrates including glucose (sugar)." ; dc:date "2016-12-17T14:21:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by carbohydrate ingestion"@en ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0025258 obo:IAO_0000115 "A sensation of tightness in the neck when attempting to move it, especially after a period of inactivity. Neck stiffness often involves soreness and difficulty moving the neck, especially when trying to turn the head to the side." ; dc:date "2016-12-18T01:06:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Neck stiffness", "Stiff neck" ; a owl:Class ; rdfs:label "Stiff neck"@en ; rdfs:subClassOf obo:HP_0001387, obo:HP_0005986 . obo:HP_0025259 obo:IAO_0000115 "A sensation of tightness in the elbow joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:11:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elbow stiffness", "Stiff elbow" ; a owl:Class ; rdfs:label "Stiff elbow"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025260 obo:IAO_0000115 "A sensation of tightness in the wrist joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:12:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stiff wrist", "Wrist stiffness" ; a owl:Class ; rdfs:label "Stiff wrist"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025261 obo:IAO_0000115 "A sensation of tightness in a finger joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:13:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Finger stiffness", "Stiff finger" ; a owl:Class ; rdfs:label "Stiff finger"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025262 obo:IAO_0000115 "A sensation of tightness in the hip joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:15:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hip stiffness", "Stiff hip" ; a owl:Class ; rdfs:label "Stiff hip"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025263 obo:IAO_0000115 "A sensation of tightness in the knee joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:16:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Knee stiffness", "Stiff knee" ; a owl:Class ; rdfs:label "Stiff knee"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025264 obo:IAO_0000115 "A sensation of tightness in the ankle joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:17:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ankle stiffness", "Stiff ankle" ; a owl:Class ; rdfs:label "Stiff ankle"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025265 obo:IAO_0000115 "A sensation of tightness in a toe joint when attempting to move it, especially after a period of inactivity." ; dc:date "2016-12-18T01:18:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stiff toe", "Toe stiffness" ; a owl:Class ; rdfs:label "Stiff toe"@en ; rdfs:subClassOf obo:HP_0001387 . obo:HP_0025266 obo:IAO_0100001 "HP:0008480" ; dc:date "2016-12-18T01:33:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Cervical osteoarthritis"@en ; owl:deprecated true . obo:HP_0025267 obo:IAO_0000115 "Deep, noisy breathing during sleep accompanied by hoarse or harsh sounds caused by the vibration of respiratory structures (especially the soft palate) resulting in sound due to obstructed air movement during breathing while sleeping." ; dc:date "2016-12-18T13:24:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Snore", "Snores", "Snoring symptoms" ; a owl:Class ; rdfs:label "Snoring"@en ; rdfs:subClassOf obo:HP_0002360, obo:HP_0002793 . obo:HP_0025268 obo:IAO_0000115 "Disruptions in the production of speech sounds, with involuntary repetitions of words or parts of words, prolongations of speech sounds, or complete blockage of speech production for several seconds." ; dc:date "2016-12-18T13:27:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stammering", "Stuttering" ; a owl:Class ; rdfs:label "Stuttering"@en ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0025269 obo:IAO_0000115 "A sudden episode of intense fear in a situation in which there is no danger or apparent cause." ; dc:date "2016-12-18T13:34:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Panic attack" ; a owl:Class ; rdfs:comment "The panic attack is accompanied by symptoms such as palpitations, sweating and chills or hot flushes. There may be a sensation of dyspnea (being out of breath), chest pain, or abdominal distress. Some individuals with panic attacks may experience depersonalization, a fear of going crazy, or a fear of dying." ; rdfs:label "Panic attack"@en ; rdfs:subClassOf obo:HP_0100852 . obo:HP_0025270 obo:IAO_0000115 "Any physiological abnormality of the esophagus." ; dc:date "2016-12-18T13:39:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of esophagus physiology", "Abnormality of oesophagus physiology", "Functional abnormality of the esophagus", "Functional abnormality of the oesophagus" ; a owl:Class ; rdfs:label "Abnormal esophagus physiology"@en ; rdfs:subClassOf obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025271 obo:IAO_0000115 "Involuntary contractions of the esophagus that are irregular, uncoordinated, and painful." ; dc:date "2016-12-18T13:45:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophageal spasms"@en ; rdfs:subClassOf obo:HP_0025270 . obo:HP_0025272 obo:IAO_0000115 "Symmetrical, blotchy, brownish facial pigmentation." ; dc:date "2016-12-18T13:48:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chloasma", "Facial melanosis" ; a owl:Class ; rdfs:comment "Melasma can be seen in individuals who have had substantial exposure to the sun, in pregnant women, with hormone treatments or as a side effect of certain medications, or with hypothyroidism, among other causes." ; rdfs:label "Melasma"@en ; rdfs:subClassOf obo:HP_0000953 . obo:HP_0025273 obo:IAO_0000115 "Inflammation of the Achilles tendon." ; dc:date "2016-12-18T13:52:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Achilles tendonitis"@en ; rdfs:subClassOf obo:HP_0025230 . obo:HP_0025274 obo:IAO_0000115 "An cystic ovarian teratoma composed of dermal and epidermal elements and containing tissue components including hair, teeth, bone, thyroid, and others." ; dc:date "2016-12-18T13:56:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mature cystic ovarian teratoma" ; a owl:Class ; rdfs:label "Ovarian dermoid cyst"@en ; rdfs:subClassOf obo:HP_0000138, obo:HP_0012226 . obo:HP_0025275 obo:IAO_0000115 "Applies to an abnormality that is located farther from the median plane or midline of the body or of the referenced structure." ; dc:date "2016-12-18T14:47:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025276 obo:IAO_0000115 "Any functional anomaly of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands." ; dc:date "2016-12-18T14:51:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of skin adnexa physiology"@en ; rdfs:subClassOf obo:HP_0001574 . obo:HP_0025277 obo:IAO_0000115 "Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating)." ; dc:date "2016-12-18T15:12:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gustatory sweating"@en ; rdfs:subClassOf obo:HP_0025276 . obo:HP_0025278 obo:IAO_0000115 "Sweating provoked by cold temperature rather than by heat." ; dc:date "2016-12-18T15:16:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cold-induced sweating"@en ; rdfs:subClassOf obo:HP_0025276 . obo:HP_0025279 dc:date "2016-12-18T15:18:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Migratory"@en ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0025280 obo:IAO_0000115 "A pain characteristic is defined as a subjective category or type of pain." ; dc:date "2016-12-18T15:21:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pain characteristic"@en ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0025281 obo:IAO_0000115 "Applied to pain that is described as sharp, i.e., sudden and severe." ; dc:date "2016-12-18T15:23:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sharp"@en ; rdfs:subClassOf obo:HP_0025280 . obo:HP_0025282 obo:IAO_0000115 "Applied to pain that is dull, i.e., not severe but that continues over a long period of time." ; dc:date "2016-12-18T15:23:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dull pain" ; a owl:Class ; rdfs:label "Dull"@en ; rdfs:subClassOf obo:HP_0025280 . obo:HP_0025283 obo:IAO_0000115 "Applied to pain that is tender, i.e., elicited by touching the affected body part." ; dc:date "2016-12-18T15:25:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tender"@en ; rdfs:subClassOf obo:HP_0025280 . obo:HP_0025284 obo:IAO_0000115 "Applied to pain that wakes the affecting individual from sleep." ; dc:date "2016-12-18T15:26:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sleep-interrupting"@en ; rdfs:subClassOf obo:HP_0025280 . obo:HP_0025285 obo:IAO_0000115 "An aggravating factor is defined as an external factor that leads to a sign or symptom that is already present getting worse or becoming more severe." ; dc:date "2016-12-18T15:29:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Exacerbated by" ; a owl:Class ; rdfs:label "Aggravated by"@en ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0025286 obo:IAO_0000115 "Applied to a sign or symptom that is aggravated by activity, exertion, or exercise." ; dc:date "2016-12-18T15:30:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aggravated by exercise", "Aggravated by exertion", "Worse with activity", "Worsened by activity" ; a owl:Class ; rdfs:label "Aggravated by activity"@en ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0025287 obo:IAO_0000115 "Applies to an abnormality that is situated in the central part of the body, in the head and trunk as distinguished from the limbs." ; dc:date "2016-12-18T15:34:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Axial"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025289 obo:IAO_0000115 "Enlarged lymph nodes in the neck." ; dc:date "2016-12-18T15:40:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Swollen lymph nodes in the neck" ; a owl:Class ; rdfs:label "Cervical lymphadenopathy"@en ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0025290 obo:IAO_0000115 "Applies to an abnormality that affects the arms, trunk, head more than the legs." ; dc:date "2016-12-18T16:11:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Upper-body predominance"@en ; rdfs:subClassOf obo:HP_0012838 . obo:HP_0025291 obo:IAO_0000115 "Applies to an abnormality that affects the legs more than the arms, trunk, head." ; dc:date "2016-12-18T16:12:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lower-body predominance"@en ; rdfs:subClassOf obo:HP_0012838 . obo:HP_0025292 obo:IAO_0000115 "Applies to an abnormality that affects the distal portions of limbs (hand, foot) and head (ears, nose)." ; dc:date "2016-12-18T16:15:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acral"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025293 obo:IAO_0000115 "Applies to an abnormality whose localization corresponds to the lines of Blaschko, which correspond to the lineage of epithelia cells. Blaschko lines are normally invisible but may become apparent with certain skin diseases and then can be seen to be distributed in lines horizontal to the body." ; dc:date "2016-12-18T16:16:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Distributed along Blaschko lines"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025294 obo:IAO_0000115 "Applies to an abnormality whose localization corresponds to the dermatomes, i.e., the nerve root distribution." ; dc:date "2016-12-18T16:17:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Radicular" ; a owl:Class ; rdfs:comment "This distribution can be seen with certain skin findings such as shingles. The term radicular is used to describe a dermatomal distribution of nerve root pain." ; rdfs:label "Dermatomal"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025295 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance resembles that of the grouped umbilicated vesicles seen in herpes simplex and herpes zoster infections." ; dc:date "2016-12-18T16:19:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Herpetiform"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025296 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance resembles that of measles, i.e., maculopapular lesions that are red and roughly 2 to 10 mm in diameter and may be partially confluent." ; dc:date "2016-12-18T16:20:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Morbilliform"@en ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0025297 obo:IAO_0000115 "Applied to an abnormality whose duration is extended over a longer period of time than is expected or usual (e.g., prolonged fever lasts longer than one usually sees with an infection)." ; dc:date "2016-12-18T16:26:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Prolonged"@en ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0025300 obo:IAO_0000115 "An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose." ; dc:date "2016-12-20T11:59:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Butterfly rash", "Cheekbone rash" ; a owl:Class ; rdfs:comment "This type of rash is seen in lupus erythematosus, but also in other diseases such as rosacea and seborrheic dermatitis." ; rdfs:label "Malar rash"@en ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0025301 obo:IAO_0000115 "Applies to an abnormality that occurs in or is exacerbated during the night." ; dc:date "2016-12-20T12:30:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nocturnal"@en ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0025302 obo:IAO_0000115 "Applies to a sign, symptom, or other abnormality that occurs in or is exacerbated in the day time." ; dc:date "2016-12-20T12:31:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diurnal"@en ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0025303 obo:IAO_0000115 "Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present." ; dc:date "2016-12-21T00:51:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Now and then" ; a owl:Class ; rdfs:comment "In our definition, episodic is synonymous with intermittent and recurrent. The term does not imply any particular temporal pattern of the recurrence." ; rdfs:label "Episodic"@en ; rdfs:subClassOf obo:HP_0031796 . obo:HP_0025304 obo:IAO_0000115 "Applies to a sign, symptom, or other manifestation that recurs with a fixed time interval, i.e., the symptom-free periods are always of the same length." ; dc:date "2016-12-21T00:55:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cyclic", "Cyclical" ; a owl:Class ; rdfs:label "Periodic"@en ; rdfs:subClassOf obo:HP_0031796 . obo:HP_0025305 obo:IAO_0000115 "Applies to a sign, symptom, or other manifestation that is episodic with a fixed time interval of one day (24 hours)." ; dc:date "2016-12-21T00:57:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Quotidian"@en ; rdfs:subClassOf obo:HP_0025304 . obo:HP_0025306 obo:IAO_0000115 "Acute appearance of disease manifestations in a period of minutes." ; dc:date "2016-12-21T01:00:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acute emergence over minutes"@en ; rdfs:subClassOf obo:HP_0011009 . obo:HP_0025307 obo:IAO_0000115 "Acute appearance of disease manifestations in a period of hours." ; dc:date "2016-12-21T01:01:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acute emergence over hours"@en ; rdfs:subClassOf obo:HP_0011009 . obo:HP_0025308 obo:IAO_0000115 "Acute appearance of disease manifestations in a period of days." ; dc:date "2016-12-21T01:01:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acute emergence over days"@en ; rdfs:subClassOf obo:HP_0011009 . obo:HP_0025309 obo:IAO_0000115 "A deviation from the normal circular shape of the pupil" ; dc:date "2016-12-21T01:08:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Irregular pupil" ; a owl:Class ; rdfs:label "Abnormal pupil shape"@en ; rdfs:subClassOf obo:HP_0000615 . obo:HP_0025310 obo:IAO_0000115 "An abnormal pupil shape that is elliptical, i.e., egg-like." ; dc:date "2016-12-21T01:11:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oval pupil"@en ; rdfs:subClassOf obo:HP_0025309 . obo:HP_0025311 obo:IAO_0000115 "A closed sac, having a distinct membrane and division compared to the nearby tissue located within the anterior chamber. The sac that may contain air, fluids, or semi-solid material." ; dc:date "2016-12-21T01:32:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cyst"@en ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0025312 obo:IAO_0000115 "A form of strabismus with both eyes turned inward to a relatively mild degree, usually defined as less than 10 prism diopters." ; dc:date "2016-12-21T01:43:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophoria"@en ; rdfs:subClassOf obo:HP_0020045, obo:HP_0032011 . obo:HP_0025313 obo:IAO_0000115 "A form of strabismus with one or both eyes deviated outward to a milder degree than with exotropia." ; dc:date "2016-12-21T01:46:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exophoria"@en ; rdfs:subClassOf obo:HP_0020049, obo:HP_0032011 . obo:HP_0025314 obo:IAO_0000115 "A benign, flat or slightly elevated melanocytic lesions of the posterior uveawith clearly defined margins. Choroidal nevi tend they remain stable in size, and to display features such as overlying drusen as well as retinal pigment epithelial atrophy, hyperplasia or fibrous metaplasia." ; dc:date "2016-12-21T01:54:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Choroidal nevus"@en ; rdfs:subClassOf obo:HP_0000610 . obo:HP_0025315 obo:IAO_0000115 "Applies to a sign or symptom that is worsened, aggravated, or exacerbated by head trauma." ; dc:date "2016-12-21T02:22:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Childhood ataxia with central nervous system hypomyelination/vanishing white matter disease is an autosomal recessive disorder characterized by ataxia, spasticity, and variable optic atrophy. Chronic progressive decline can be exacerbated by rapid deterioration during febrile illnesses or following head trauma." ; rdfs:label "Exacerbated by head trauma"@en ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0025317 obo:IAO_0000115 "A deformity of the elbow in which there is a deviation of the forearm toward the midline of the body." ; dc:date "2017-01-13T13:20:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Normally, if the arm is held in full extension, the forearm is aligned in valgus with respect to the arm. A decrease in valgus with neutral alignment (loss of angulation) is called cubitus rectus, and a further decreases is called varus. Cubitus varus may be congenital (often progressive), or may be a complication of humerus fracture, trochlear osteonecrosis, and malunited intercondylar fracture. Radiographically, the metaphyseo-diaphyseal angle is normally 90 degrees. With cubitus varus, the angle is larger, with cubitus valgus, the angle is smaller." ; rdfs:label "Cubitus varus"@en ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0025318 obo:IAO_0000115 "A malignant neoplasm originating from the surface ovarian epithelium." ; dc:date "2017-01-25T14:30:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C4908" ; oboInOwl:hasExactSynonym "Ovarian epithelial cancer" ; a owl:Class ; rdfs:label "Ovarian carcinoma"@en ; rdfs:subClassOf obo:HP_0100615 . obo:HP_0025319 obo:IAO_0000115 "Formation of new blood vessels on the iris. The new vessels do not display the typical radially symmertic growth pattern of normal iris blood vessels, but rather appear disorganized. Rubeosis usually starts from the pupillary border with tiny tufts of dilated capillaries or red spots that can only be appreciated with high magnification." ; dc:date "2017-01-25T14:46:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rubeosis iridis"@en ; rdfs:subClassOf obo:HP_0007905 . obo:HP_0025320 obo:IAO_0000115 "Leakage of fluorescein dye observed upon retinal fluorescein angiography. Areas of leakage can be appreciated as showing gradual enlargement with blurring of margins." ; dc:date "2017-01-25T14:52:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fluorescein leakage" ; a owl:Class ; rdfs:comment "Leakage can be caused by incompetent blood vessels such as with choroidal or diabetic neovascularization. Alternatively, leakage can be associated with a diseased retinal pigment epithelium resulting in leakage of fluorescein from the choroid." ; rdfs:label "Leakage of dye on fundus fluorescein angiography"@en ; rdfs:subClassOf obo:HP_0030604 . obo:HP_0025321 obo:IAO_0000115 "An anomalous build up of copper (Cu) in the liver." ; dc:date "2017-02-03T11:46:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liver copper accumulation" ; a owl:Class ; rdfs:label "Copper accumulation in liver"@en ; rdfs:subClassOf obo:HP_0034644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025322 obo:IAO_0000115 "Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein." ; dc:date "2017-02-03T12:05:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Venous occlusion"@en ; rdfs:subClassOf obo:HP_0030846 . obo:HP_0025323 obo:IAO_0000115 "An anomaly of arterial function." ; dc:date "2017-02-03T12:08:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal arterial physiology"@en ; rdfs:subClassOf obo:HP_0030163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025324 obo:IAO_0000115 "Blockage of blood flow through an artery." ; dc:date "2017-02-03T12:09:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arterial occlusion"@en ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0025325 obo:IAO_0000115 "Decreased density/number and/or decreased diameter of medial eyebrow hairs." ; dc:date "2017-02-04T16:43:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial thinning of eyebrow" ; a owl:Class ; rdfs:label "Sparse medial eyebrow"@en ; rdfs:subClassOf obo:HP_0045075 . obo:HP_0025326 obo:IAO_0000115 "Blockage of the retinal artery, generally associated with interruption of blood flow and oxygen delivery to the retina." ; dc:date "2017-02-04T17:22:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Retinal artery occlusion" ; a owl:Class ; rdfs:comment "Retinal artery occlusion can manifest as painless loss of monocular vision." ; rdfs:label "Retinal arterial occlusion"@en ; rdfs:subClassOf obo:HP_0000630 . obo:HP_0025327 obo:IAO_0000115 "Reduced dimension of the solid part of the kidney (parenchyma, the renal cortex and medulla) as measured from the collecting system (renal calyces and pelvis) to the border of the kidney. This measurement can be performed by measuring the thickness of the parenchyma in computed tomography scans." ; dc:date "2017-02-11T10:48:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The thickness of the renal parenchyma decreases with age. The thickness of the renal parenchyma is correlated with renal function." ; rdfs:label "Decreased renal parenchymal thickness"@en ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0025328 obo:IAO_0000115 "Significant maternal hemorrhage/bleed in the second half of pregnancy and prior to the birth of the baby." ; dc:date "2017-02-11T11:09:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Antepartum haemorrhage", "Prepartum haemorrhage", "Prepartum hemorrhage" ; a owl:Class ; rdfs:label "Antepartum hemorrhage"@en ; rdfs:subClassOf obo:HP_0011029 . obo:HP_0025329 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against glutamic acid decarboxylase." ; dc:date "2017-02-11T11:15:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-GAD antibody positivity" ; a owl:Class ; rdfs:comment "The enzyme called glutamate decarboxylase or glutamic acid decarboxylase (GAD) catalyyzes the conversion of glutamate to gamma aminobutyric acid (g-Amino butyric acid, GABA). Autoantibodies against GAD this antibody may block the conversion of glutamate to GABA. and lead to a reduction in the amount of GABA in the nervous system." ; rdfs:label "Anti-glutamic acid decarboxylase antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025330 obo:IAO_0000115 "A limitation of the ability to direct one's gaze below the horizontal meridian." ; dc:date "2017-02-11T11:41:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Downgaze paresis", "Supranuclear downgaze palsy" ; a owl:Class ; rdfs:label "Downgaze palsy"@en ; rdfs:subClassOf obo:HP_0000511 . obo:HP_0025331 obo:IAO_0000115 "A limitation of the ability to direct one's gaze above the horizontal meridian." ; dc:date "2017-02-11T11:54:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Supranuclear upgaze palsy", "Upgaze paresis" ; a owl:Class ; rdfs:label "Upgaze palsy"@en ; rdfs:subClassOf obo:HP_0000511 . obo:HP_0025332 obo:IAO_0000115 "An anomaly of the outer shell (cortex) of a foot bone." ; dc:date "2017-02-11T12:09:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of the cortex of foot bones" ; a owl:Class ; rdfs:label "Abnormality of foot cortical bone"@en ; rdfs:subClassOf obo:HP_0003103 . obo:HP_0025333 obo:IAO_0000115 "A reduction in the thickness of the outer shell (cortex) of foot bones." ; dc:date "2017-02-11T12:10:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical thinning of foot bones"@en ; rdfs:subClassOf obo:HP_0025332 . obo:HP_0025334 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by a strong spontaneously arising mental state, reaction or feeling (emotion)." ; dc:date "2017-02-12T11:38:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Emotion triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by emotion"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025335 obo:IAO_0000115 "A failure to achieve the ability to stand up at an appropriate developmental stage. Most children begin to walk alone at 11 to 15 months of age. On average, children can stand while holding on at the age of 9 to 10 months, can pull up to stand and walk with one hand being held at 12 months, and can stand alone and walk well at 18 months." ; dc:date "2017-02-12T11:48:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Child can stand in an upright position on both feet, holding onto a stable object (eg, furniture) for at least 10 s without leaning on it." ; rdfs:label "Delayed ability to stand"@en ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0025336 obo:IAO_0000115 "A failure to achieve the ability to sit at an appropriate developmental stage. Most children sit with support at 6 months of age and sit steadily without support at 9 months of age." ; dc:date "2017-02-12T12:04:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This milestone can be defined as the ability of an infant to sit up straight with head erect for at least 10 s without using arms or hands to balance body or support the position." ; rdfs:label "Delayed ability to sit"@en ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0025337 obo:IAO_0000115 "A reddish appearance over the white part (sclera) of the eye ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera." ; dc:date "2017-02-12T12:27:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Red eye", "Red eyes" ; a owl:Class ; rdfs:label "Red eye"@en ; rdfs:subClassOf obo:HP_0008047 . obo:HP_0025338 obo:IAO_0000115 "A ring of redness at the limbus of the eye, the border between the cornea and the sclera." ; dc:date "2017-02-12T12:32:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ciliary limbus", "Circumlimbal hyperaemia" ; a owl:Class ; rdfs:label "Circumlimbal hyperemia"@en ; rdfs:subClassOf obo:HP_0030953 . obo:HP_0025339 obo:IAO_0000115 "Prominence of blood vessels of the superficial episcleral tissues." ; dc:date "2017-02-12T12:45:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Superficial episcleral hypaeremia" ; a owl:Class ; rdfs:comment "The episclera is a fibroelastic structure with two loosely joined layers. The superficial layer contains vessels of the superficial episcleral capillary plexus that appear straight and are arranged in a radial fashion. The deeper layer contains a highly anastomotic network of blood vessels. The episclera and sclera have a separate blood supply from that of the conjunctiva. Conjunctival hyperemia can be distinguished from episceral hyperemia because conjunctival hyperemia is characterized by finer, less tortuous vessels but deeper episcleral hyperemia maybe violaceous. The conjunctival vessels but not the deeper vessels can be moved by massaging with a cotton swab." ; rdfs:label "Superficial episcleral hyperemia"@en ; rdfs:subClassOf obo:HP_0000591, obo:HP_0025337 . obo:HP_0025340 obo:IAO_0000115 "Prominence of blood vessels of the deep episcleral tissues." ; dc:date "2017-02-12T13:00:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Deep episcleral hyperaemia" ; a owl:Class ; rdfs:comment "The episclera is a fibroelastic structure with two loosely joined layers. The superficial layer contains vessels of the superficial episcleral capillary plexus that appear straight and are arranged in a radial fashion. The deeper layer contains a highly anastomotic network of blood vessels. The episclera and sclera have a separate blood supply from that of the conjunctiva. Conjunctival hyperemia can be distinguished from episceral hyperemia because conjunctival hyperemia is characterized by finer, less tortuous vessels but deeper episcleral hyperemia maybe violaceous. The conjunctival vessels but not the deeper vessels can be moved by massaging with a cotton swab." ; rdfs:label "Deep episcleral hyperemia"@en ; rdfs:subClassOf obo:HP_0000591, obo:HP_0025337 . obo:HP_0025341 obo:IAO_0000115 "An inflammatory cellular deposit deposited on the corneal endothelium and visible as spots on the cornea." ; dc:date "2017-02-12T13:03:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Keratic precipitates may collect in a triangular pattern called Arit triangle with the base down on the lower part of theendothelial surface or may be distributed diffusely accross the endothelium. If they are greasy in appearance, the term mutton fat keratic precipitate is used." ; rdfs:label "Corneal keratic precipitates"@en ; rdfs:subClassOf obo:HP_0011488 . obo:HP_0025342 obo:IAO_0000115 "Blockage of the main artery in the retina. The typical presentation is one of profound monocular visual loss." ; dc:date "2017-02-12T13:17:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Central retinal artery occlusion canmanifest as sudden, acute, and painless loss of vision in one eye." ; rdfs:label "Central retinal artery occlusion"@en ; rdfs:subClassOf obo:HP_0025326, obo:HP_3000032 . obo:HP_0025343 obo:IAO_0000115 "Presence of lupus anticoagulant (LA) autoantibodies. LA represent a heterogeneous group of autoantibodies, IgG, IgM, or a mixture of both classes, that interfere with standard phospholipid-based coagulant tests (this is only an in vitro phenomenon, LA do not cause reduction of coagulation in vivo). The antibodies are directed against plasma proteins which also bind to phospholipid surfaces." ; dc:date "2017-02-12T13:19:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Most individuals with lupus anticoagulant do not have lupus erythematosus or other systemic autoimmune disorders. One of the tests for lupus anticoagulant is the dilute Russell's viper venom time (dRVVT)." ; rdfs:label "Lupus anticoagulant"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025344 obo:IAO_0000115 "Damage to and obliteration of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts)." ; dc:date "2017-02-12T13:44:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In primary biliary cirrhosis, interlobular bile duct destruction is immune mediated." ; rdfs:label "Interlobular bile duct destruction"@en ; rdfs:subClassOf obo:HP_0011040 . obo:HP_0025345 obo:IAO_0000115 "A deviation from the normal concentration of beta-2-microglobulin in the blood." ; dc:date "2017-02-12T13:50:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of circulating B2M level", "Abnormality of circulating beta2 microglobulin level", "Abnormality of circulating beta2-m level", "Abnormality of circulating beta2m level" ; a owl:Class ; rdfs:label "Abnormality of circulating beta-2-microglobulin level"@en ; rdfs:subClassOf obo:HP_0025465 . obo:HP_0025346 obo:IAO_0000115 "Elevated concentration of beta-2-microglobulin in the blood." ; dc:date "2017-02-12T13:53:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating beta-2-microglobulin level" ; a owl:Class ; rdfs:label "Increased circulating beta-2-microglobulin level"@en ; rdfs:subClassOf obo:HP_0025345 . obo:HP_0025347 obo:IAO_0000115 "Reduced concentration of beta-2-microglobulin in the blood." ; dc:date "2017-02-12T13:54:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced circulating beta-2-microglobulin level" ; a owl:Class ; rdfs:label "Decreased circulating beta-2-microglobulin level"@en ; rdfs:subClassOf obo:HP_0025345 . obo:HP_0025348 obo:IAO_0000115 "An anomaly of the margin of the cornea overlapped by the sclera." ; dc:date "2017-02-12T23:58:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of the corneal limbus" ; a owl:Class ; rdfs:label "Abnormal corneal limbus morphology"@en ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006761 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025349 obo:IAO_0000115 "Swelling of the margin of the cornea overlapped by the sclera." ; dc:date "2017-02-12T23:59:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Limbal oedema" ; a owl:Class ; rdfs:label "Limbal edema"@en ; rdfs:subClassOf obo:HP_0025348 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006761 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025350 obo:IAO_0000115 "Conjunctival papillae with a diameter greater than 1 millimeter. They characteristically have flattened tops which sometimes demonstrate staining with fluorescein." ; dc:date "2017-02-13T00:05:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Giant conjunctival papillae"@en ; rdfs:subClassOf obo:HP_0030946 . obo:HP_0025351 obo:IAO_0000115 "A history of repeated fungal infections located between the fingers or toes, usually manifested by scaling, maceration, and itching. The toes are more commonly affected than the fingers." ; dc:date "2017-02-13T00:11:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Recurrent interdigital tinea" ; a owl:Class ; rdfs:label "Recurrent interdigital mycosis"@en ; rdfs:subClassOf obo:HP_0002841 . obo:HP_0025352 obo:IAO_0000115 "Description of conditions that are exclusively or predominantly observed to display de novo variants. In some cases, this may be due to the limited reproductive fitness of affected individuals." ; dc:date "2017-02-13T00:19:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Autosomal dominant germline de novo mutation" ; a owl:Class ; rdfs:label "Typically de novo"@en ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0025353 obo:IAO_0000115 "A type of antinuclear antibody (ANA) positivity revealed by indirect immunofluorescence (IFL). The multiple nuclear dots (MND) pattern is immunomorphologically characterized by the staining of 3-20 dots of variable size distributed all over the cell nucleus, but sparing the nucleoli, and, in contrast to the anticentromere pattern, MND reactivity does not stain the chromosomes in mitotic cells." ; dc:date "2017-02-13T00:25:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-MND antibodies" ; a owl:Class ; rdfs:comment "Sp100 is the main antigenic target of MND reactivity. Anti-MND activity can be seen in primary biliary cirrhosis and in other conditions. Anti-sp100 antibodies are directed against sp100 antigen found within nuclear bodies; large protein complexes in the nucleus that may have a role in cell growth and differentiation. Anti-sp100 antibodies are found in approximately 20-30% of patients diagnosed with primary biliary cirrhosis (PBC)." ; rdfs:label "Anti-multiple nuclear dots antibody positivity"@en ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0025354 obo:IAO_0000115 "An anomaly of cellular morphology or physiology." ; dc:date "2017-02-13T00:29:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cellular phenotype"@en ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025355 obo:IAO_0000115 "Acquired focal dilatations of branches of the retinal artery, usually second-order retinal arterioles, that range in size from 100 to 200 micrometers in diameter. Macroaneurysms are generally located at the termporal retina and may be hemorrhagic or exudative." ; dc:date "2017-02-13T00:33:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Retinal arterial macroaneurysms can be visualized on fundoscopy and by fluorescein angiography or spectral-domain optical coherence tomography." ; rdfs:label "Retinal arterial macroaneurysms"@en ; rdfs:subClassOf obo:HP_0000630 . obo:HP_0025356 obo:IAO_0100001 "HP:0001263" ; dc:date "2017-02-17T11:43:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Psychomotor retardation"@en ; owl:deprecated true . obo:HP_0025357 obo:IAO_0000115 "A type of myoclonus in which the myoclonias shift from body region to another in a random and asynchronous fashion. Erratic myoclonus can affect the face or limbs, are brief, single or repetitive, very frequent and nearly continuous." ; dc:date "2017-02-17T12:01:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fragmentary myoclonus" ; a owl:Class ; rdfs:comment "Erratic may appear immediately after birth.Definition adapted from The Epilepsies: Seizures, Syndromes and Management; Chapter 5: Neonatal Seizures and Neonatal Syndromes; NCBI Book NBK2599." ; rdfs:label "Erratic myoclonus"@en ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0025358 obo:IAO_0000115 "Presence of iris pigment epithelium on the anterior surface of the iris." ; dc:date "2017-02-17T12:10:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ectropion uveae" ; a owl:Class ; rdfs:label "Uveal ectropion"@en ; rdfs:subClassOf obo:HP_0000525 . obo:HP_0025359 obo:IAO_0000115 "An abnormal polygonal shape of the calices of the kidney (which normally have a rounded or cup-shaped appearance)." ; dc:date "2017-02-17T12:14:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Polygonal calices", "Polygonal-shaped calices" ; a owl:Class ; rdfs:label "Polygonal renal calices"@en ; rdfs:subClassOf obo:HP_0011130 . obo:HP_0025360 obo:IAO_0000115 "Increased number of calices of the kidney." ; dc:date "2017-02-17T12:17:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polycalycosis"@en ; rdfs:subClassOf obo:HP_0011130 . obo:HP_0025361 obo:IAO_0000115 "A structural anomaly of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla." ; dc:date "2017-02-20T13:15:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of medullary pyramid morphology"@en ; rdfs:subClassOf obo:HP_0100957 . obo:HP_0025362 obo:IAO_0000115 "Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla." ; dc:date "2017-02-20T13:16:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoplasia of the medullary pyramids" ; a owl:Class ; rdfs:label "Renal medullary pyramid hypoplasia"@en ; rdfs:subClassOf obo:HP_0025361 . obo:HP_0025363 obo:IAO_0000115 "Hypercellularity due to increased number of cells within glomerular capillary lumina, causing narrowing of the lumina." ; dc:date "2017-02-20T13:33:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endocapillary hypercellularity" ; a owl:Class ; rdfs:comment "The endocapillary compartment of the glomerulus includes the endothelial cells, mesangial cells, and any leukocytes in the capillary lumens or mesangium." ; rdfs:label "Glomerular endocapillary hypercellularity"@en ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0025364 obo:IAO_0000115 "Hypercellularity (increased number of cells) in the renal glomerulus but external to the glomerular capillaries, i.e., in the Bowman space or more than one layer of parietal or visceral epithelial cells." ; dc:date "2017-02-20T14:07:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Extracapillary glomerular hypercellularity", "Extracapillary hypercellularity" ; a owl:Class ; rdfs:label "Glomerular extracapillary hypercellularity"@en ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0025367 obo:IAO_0000115 "A benign hair follicle tumor whose tumor cells form rudimentary hair follicles but not actual hair shafts. A trichoepithelioma is usually less than one centimeter, firm, round, and shihy with yellow, pink, brown, or bluish color. They may occur multiply, usually on the face, and may gradually increase in number with age." ; dc:date "2017-02-20T14:24:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Trichoepithelioma"@en ; rdfs:subClassOf obo:HP_0012843 . obo:HP_0025368 obo:IAO_0000115 "A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone)." ; dc:date "2017-02-20T14:32:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of growth plate morphology" ; a owl:Class ; rdfs:label "Abnormal growth plate morphology"@en ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0025369 obo:IAO_0000115 "Increased thickness (dimension along the axis of the bone) of the growth plate." ; dc:date "2017-02-20T14:40:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thick growth plates"@en ; rdfs:subClassOf obo:HP_0025368 . obo:HP_0025370 obo:IAO_0000115 "Abnormal bone tissue formation (ossification) affecting the sacrum." ; dc:date "2017-02-20T14:45:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ossification of the sacrum"@en ; rdfs:subClassOf obo:HP_0005107 . obo:HP_0025371 obo:IAO_0000115 "Formation of the sacrum bone tissue occurs later than age-adjusted norms." ; dc:date "2017-02-20T14:47:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed ossification of the sacrum"@en ; rdfs:subClassOf obo:HP_0025370 . obo:HP_0025372 obo:IAO_0000115 "Particularly loud snoring, snoring at high volume." ; dc:date "2017-03-15T11:53:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Has loud snoring", "Have loud snoring", "Heavy snoring", "Snores loudly" ; a owl:Class ; rdfs:label "Loud snoring"@en ; rdfs:subClassOf obo:HP_0025267 . obo:HP_0025373 obo:IAO_0000115 "Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge." ; dc:date "2017-03-15T13:25:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interictal EEG abnormality"@en ; rdfs:subClassOf obo:HP_0002353 . obo:HP_0025374 obo:IAO_0000115 "The presence of two distinct odontoid processes. The odontoid process, also known as the dens of the axis, is a protuberance of the C2 vertebral body around which the first vertebra rotates." ; dc:date "2017-04-08T13:00:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment """The odontoid process forms from different ossification centers. Two centers normally appear on each side of the midline around the fifth or sixth month of fetal life. These two centers usually fuse by one year of age. When there is a delay in fusion, a longitudinal midline cleft may be seen. Duplication of the odontoid process most likely is the result of a lack of fusion of these two centers of ossification [from PMID:9367321].""" ; rdfs:label "Duplicated odontoid process"@en ; rdfs:subClassOf obo:HP_0003310 . obo:HP_0025375 obo:IAO_0000115 "Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process.With dystopic os odontoideum, the ossicle is located near the basion or is fused with the clivus." ; dc:date "2017-04-08T13:10:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orthotopic os odontoideum"@en ; rdfs:subClassOf obo:HP_0005667 . obo:HP_0025376 obo:IAO_0000115 "An increased concentration of glutamine in the urine." ; dc:date "2017-04-08T13:20:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glutamine high in urine", "Glutaminuria" ; a owl:Class ; rdfs:label "Hyperglutaminuria"@en ; rdfs:subClassOf obo:HP_0033093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025377 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exertion or physical exercise." ; dc:date "2017-04-08T13:36:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Exertion triggered symptoms", "Triggered by physical exercise" ; a owl:Class ; rdfs:comment "For convenience, several HPO terms exist with the phrase 'Exercise-induced' in their label. This is meant to be logically equvalent to the combination of the basis term and this modifier." ; rdfs:label "Triggered by exertion"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0025379 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase." ; dc:date "2017-04-20T10:42:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-TPO antibody positivity", "TPOAbs" ; a owl:Class ; rdfs:comment "Thyroid peroxidase (TPO) antibody positivity is found in most patients with chronic lymphocytic thyroiditis (Hashimoto disease) and over half of patients with Graves disease." ; rdfs:label "Anti-thyroid peroxidase antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025380 obo:IAO_0000115 "Increased concentration of androstenedione in the blood circulation." ; dc:date "2017-04-20T10:48:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased serum androstenedione" ; a owl:Class ; rdfs:comment "4-Androstenedione is the common precursor of the androgen and estrogen sex hormones and is produced in the adrenal glands and the gonads." ; rdfs:label "Increased circulating androstenedione concentration"@en ; rdfs:subClassOf obo:HP_0030348, obo:HP_0033811 . obo:HP_0025381 obo:IAO_0000115 "Circulating antipituitary antibodies (APA) are markers of autoimmune hypophysitis, which may cause deficient pituitary function." ; dc:date "2017-04-20T10:52:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The presence of autoantibodies (immunoglobulins) in the serum that react against pituitary tissue." ; rdfs:label "Anti-pituitary antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025382 obo:IAO_0000115 "Reduced fluid intake (drinking) in a clinical situation where the plasma molarity or sodium concentration normally would induce greater fluid intake." ; dc:date "2017-04-20T11:10:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypodipsia"@en ; rdfs:subClassOf obo:HP_0030082 . obo:HP_0025383 obo:IAO_0000115 "An area of fat accumulation at the back of the neck in the form of a hump." ; dc:date "2017-04-21T11:39:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Buffalo hump" ; a owl:Class ; rdfs:label "Dorsocervical fat pad"@en ; rdfs:subClassOf obo:HP_0001001 . obo:HP_0025384 obo:IAO_0000115 "Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery." ; dc:date "2017-04-21T11:45:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In certain diseases such as multiple symmetric lipomatosis, lipedema and Dercum's disease, accumulation of subcutaneous adipose tissue may result from growth of an abnormal brown stem cell population or from vascular or lymphatic dysfunction, with the result that the subcutaneous adipose tissue is difficult or impossible to reduce by caloric limitation and increased energy expenditure." ; rdfs:label "Diet-resistant subcutaneous adipose tissue"@en ; rdfs:subClassOf obo:HP_0009124 . obo:HP_0025385 obo:IAO_0000115 "Areas of subcutanous fat tissue below the waist that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery." ; dc:date "2017-04-21T11:55:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diet-resistant subcutaneous adipose tissue below waist"@en ; rdfs:subClassOf obo:HP_0025384 . obo:HP_0025386 obo:IAO_0000115 "Depression of profile in both temporal regions." ; dc:date "2017-04-21T12:00:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bitemporal hollowing"@en ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0025387 obo:IAO_0000115 "A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other." ; dc:date "2017-04-21T12:11:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pill rolling" ; a owl:Class ; rdfs:comment "The name pill rolling derives from the movements that pharmacists made in earlier times when making pills by rolling them together." ; rdfs:label "Pill-rolling tremor"@en ; rdfs:subClassOf obo:HP_0002322 . obo:HP_0025388 obo:IAO_0000115 "A nodular lesion that develops in the thyroid gland. The term \"thyroid nodule\" refers to any abnormal growth that forms a lump in the thyroid gland." ; dc:date "2017-04-22T11:06:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The vast majority of thyroid nodules are benign (noncancerous), but a small proportion of thyroid nodules do contain thyroid cancer." ; rdfs:label "Thyroid nodule"@en ; rdfs:subClassOf obo:HP_0011772 . obo:HP_0025389 obo:IAO_0000115 "High-resolution computed tomography (HRCT) can distinguish findings that characterize characterise interstitial lung diseases in a way not possible with other modalities." ; dc:date "2017-04-22T12:46:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary interstitiatial HRCT abnormality" ; a owl:Class ; rdfs:label "Pulmonary interstitial high-resolution computed tomography abnormality"@en ; rdfs:subClassOf obo:HP_0006530, obo:HP_0031983 . obo:HP_0025390 obo:IAO_0000115 "On pulmonary high-resolution computed tomography, reticular pattern is characterised by innumerable interlacing shadows suggesting a mesh." ; dc:date "2017-04-22T12:55:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The constituents of the reticular pattern may be all or some of the following: interlobular septal thickening, intralobular interstitial thickening, wall cysts of honeycombing, peribronchovascular interstitial thickening and traction bronchiectasis/bronchiolectasis" ; rdfs:label "Reticular pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025391 obo:IAO_0000115 "The so-called crazy paving pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia." ; dc:date "2017-04-22T12:57:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0033659" ; oboInOwl:hasExactSynonym "Crazy paving pattern on pulmonary HRCT", "Crazy-paving pattern" ; a owl:Class ; rdfs:comment "See Figure 20 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Crazy paving pattern"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025392 obo:IAO_0000115 "A nodular pattern is characterised on pulmonary high-resolution computed tomography by the presence of numerous rounded opacities that range from 2 mm to 1 cm in diameter, with micronodules defined as smaller than 3 mm in diameter." ; dc:date "2017-04-22T12:59:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nodular pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025393 obo:IAO_0000115 "Co-occurrence of reticular and micronodular patterns on pulmonary high-resolution computed tomography." ; dc:date "2017-04-22T13:02:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reticulonodular pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025394 obo:IAO_0000115 "On pulmonary high-resolution computed tomography, the cystic pattern is composed by well-defined, round and circumscribed air-containing parenchymal spaces with a well-defined wall and interface with normal lung. The wall of the cysts may be uniform or varied in thickness, but usually is thin (less than 2 mm) and occurs without associated emphysema." ; dc:date "2017-04-22T13:03:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cystic pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025395 obo:IAO_0000115 "Co-occurrence of the cystic pattern and the ground-glass pattern on pulmonary high-resolution computed tomography," ; dc:date "2017-04-22T13:05:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Combined cystic and ground-glass pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0031457 . obo:HP_0025396 obo:IAO_0000115 "Areas of low density corresponding to parenchymal destruction and reduced perfusion, and attenuation of the pulmonary vasculature, as visualized on pulmonary high-resolution computed tomography." ; dc:date "2017-04-22T13:08:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Black lung pattern on pulmonary HRCT" ; a owl:Class ; rdfs:label "Decreased attenuation pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025397 obo:IAO_0000115 "A patchwork of intermingled areas of increased and decreased attenuation visualized on pulmonary high-resolution computed tomography." ; dc:date "2017-04-22T13:10:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mosaic attenuation pattern may represent patchy interstitial disease, obliterative small airways disease, or occlusive small vascular disease." ; rdfs:label "Mosaic attenuation pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0025398 obo:IAO_0000115 "A nodular pattern on pulmonary high-resolution computed tomography that has a perilymphatic distribution." ; dc:date "2017-04-22T13:12:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nodular-perilymphatic pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025392 . obo:HP_0025399 obo:IAO_0000115 "A nodular pattern on pulmonary high-resolution computed tomography that displays a tree-in-bud pattern, representing centrilobular branching structures that resemble a budding tree." ; dc:date "2017-04-22T13:13:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The pattern reflects a spectrum of endobronchiolar and peribronchiolar disorders, including mucoid impaction, inflammation, fibrosis and occasionally endovascular disorders such as neoplastic processes." ; rdfs:label "Nodular-centrilobular with tree-in-bud pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025392 . obo:HP_0025400 obo:IAO_0000115 "A nodular pattern on pulmonary high-resolution computed tomography that has an apparently random pattern." ; dc:date "2017-04-22T13:13:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Miliary tuberculosis and miliary metastasis are two diseases entities that can be characterized by a ranom nodular pattern on pulmonary HRCT." ; rdfs:label "Nodular-random pattern on pulmonary HRCT"@en ; rdfs:subClassOf obo:HP_0025392 . obo:HP_0025401 obo:IAO_0000115 "An abnormality in which the eyes are held permanently wide open." ; dc:date "2017-04-22T14:03:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Staring eyes" ; a owl:Class ; rdfs:comment "This is a neurological anomaly that can be observed in Parkinson and certain other diseases." ; rdfs:label "Staring gaze"@en ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0025402 obo:IAO_0000115 "Square wave jerks are saccadic eye movements which, when recorded with open eyes are considered to be a pathological sign, caused by fixation instability, and pointing to a central neurological lesion." ; dc:date "2017-04-22T14:07:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Square-wave jerks"@en ; rdfs:subClassOf obo:HP_0032114 . obo:HP_0025403 obo:IAO_0000115 "A habitual positioning of the body with the head and upper back bent forward." ; dc:date "2017-04-22T14:18:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Stooped posture"@en ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0025404 obo:IAO_0000115 "Any anomaly in the process of ocular fixation, which is the maintaining of the visual gaze on a single location." ; dc:date "2017-04-22T14:29:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal visual fixation"@en ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0025405 obo:IAO_0000115 "A deficit in the ability to fixate eye movements in order to stabilize images on the retina" ; dc:date "2017-04-22T14:31:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Instability of ocular fixation" ; a owl:Class ; rdfs:comment "Eye movements are made several times a second to place and hold images of objects of interest onto the central part of the retina, the fovea, where visual acuity is best. These eye movements fall into two main classes. Saccades are fast and brief movements, reaching peak speeds of hundreds of degrees per second and lasting only tens of milliseconds that quickly shift new visual images to the fovea. Smooth pursuit eye movements are slow and continuous, steadily rotating the eyes to track any motion of the visual target, minimizing the retinal slip and the resulting blur that might otherwise reduce spatial acuity. Between these movements, the eyes are held relatively still. These periods of steady fixation are the result of a dynamic process that appears to be actively controlled by many of the same brain structures involved in the generation of goal-directed eye movements." ; rdfs:label "Visual fixation instability"@en ; rdfs:subClassOf obo:HP_0025404 . obo:HP_0025406 obo:IAO_0000115 "A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body." ; dc:date "2017-04-22T14:48:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lack of energy and strength", "Weakness" ; oboInOwl:hasRelatedSynonym "Prostration" ; a owl:Class ; rdfs:comment "Asthenia is to be distinguished from fatigue, because asthenia refers to a sensation of exhaustion which occurs before any effort. Asthenia is to be distinguished from myasthenia, which means a specific weakness of one or more muscles. Asthenia and fatigue can coexist." ; rdfs:label "Asthenia"@en ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0025407 obo:IAO_0000115 "An abnormal connection (fistula) between the rectum and the urethra." ; dc:date "2017-04-23T10:24:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Urethrorectal fistula" ; a owl:Class ; rdfs:label "Rectourethral fistula"@en ; rdfs:subClassOf obo:HP_0010480, obo:HP_0100590 . obo:HP_0025408 obo:IAO_0000115 "Any anomaly of the structure of the spleen." ; dc:date "2017-04-23T10:55:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Splenic lesion" ; a owl:Class ; rdfs:label "Abnormal spleen morphology"@en ; rdfs:subClassOf obo:HP_0001743 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025409 obo:IAO_0000115 "Any anomaly of the function of the spleen." ; dc:date "2017-04-23T10:56:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal spleen physiology"@en ; rdfs:subClassOf obo:HP_0001743 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002106 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025410 obo:IAO_0000115 "Joining of the spleen and a gonad during embryological development." ; dc:date "2017-04-23T10:58:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The spleen is located in close proximitiy to the gonads during early embryological development, which may facilitate fusion. Splenogonadal fusion may be divided into continuous or discontinuous types, with the gonad being directly attached to the spleen in the continuous type . The discontinuous type consists of gonadal fusion with an accessory spleen or ectopic splenic tissue." ; rdfs:label "Splenogonadal fusion"@en ; rdfs:subClassOf obo:HP_0000812, obo:HP_0025408 . obo:HP_0025413 obo:IAO_0000115 "A type of urethral stricture affecting the fossa navicularis, which is the spongy part of the male urethra located at the glans penis." ; dc:date "2017-04-23T11:16:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The fossa navicularis is the small normal dilatation of the distal penile urethra." ; rdfs:label "Fossa navicularis urethral stricture"@en ; rdfs:subClassOf obo:HP_0012227 . obo:HP_0025414 obo:IAO_0000115 "A type of urethral stricture affecting the pendulous urethra, which is straight and fixed to the corpora cavernosa." ; dc:date "2017-04-23T11:17:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pendulous urethral stricture"@en ; rdfs:subClassOf obo:HP_0012227 . obo:HP_0025415 obo:IAO_0000115 "A type of urethral stricture affecting the bulbar urethra, which is the part of the urethra that traverses the root of the penis." ; dc:date "2017-04-23T11:17:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bulbar urethral stricture"@en ; rdfs:subClassOf obo:HP_0012227 . obo:HP_0025416 obo:IAO_0000115 "A narrowing of the vagina owing to scar formation." ; dc:date "2017-04-23T11:24:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vaginal stricture"@en ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0025417 obo:IAO_0000115 "Urethra more open or expanded than normal." ; dc:date "2017-04-23T11:39:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Patulous urethra"@en ; rdfs:subClassOf obo:HP_0000795 . obo:HP_0025418 obo:IAO_0000115 "Patchy or diffuse ischemic destruction of all the elements of renal cortex resulting from significantly diminished renal arterial perfusion. Coagulative necrosis may be present, involving all tubular segments and glomeruli. Nuclei may be pale and pyknotic, or may no longer be apparent. Thrombi may be present in vessels at the edge of the infarct." ; dc:date "2017-04-23T11:45:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Necrosis of the kidney cortex" ; a owl:Class ; rdfs:comment "Renal cortical necrosis is a type of actue kidney injury that results from insufficient perfusion of the renal cortex. Cortical necrosis commonly manifests clinically as a rapid loss of glomerular filtration rate, often with oliguria, granular casts, and low-level proteinuria. The key diagnostic features of renal cortical necrosis are (i) pale tissue with typical appearance of coagulative necrosis, affecting both tubules and glomeruli; (ii) pyknotic nuclei; and (iii) simplified, flattened epithelium of proximal tubules." ; rdfs:label "Renal cortical necrosis"@en ; rdfs:subClassOf obo:HP_0011035, obo:HP_0032618 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001225 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025419 obo:IAO_0000115 "A pneumatocele is a thin walled, gas-filled space in the lung. It is most frequently caused by acute pneumonia, trauma, or aspiration of hydrocarbon fluid and is usually transient. The mechanism is believed to be a combination of parenchymal necrosis and check-valve airway obstruction. A pneumatocele appears as an approximately round, thin-walled airspace in the lung." ; dc:date "2017-04-23T11:52:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary pneumatocoele" ; a owl:Class ; rdfs:comment "See Figure 52 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary pneumatocele"@en ; rdfs:subClassOf obo:HP_0032445 . obo:HP_0025420 obo:IAO_0000115 "A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen." ; dc:date "2017-04-23T12:16:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Diffuse alveolar haemorrhage" ; a owl:Class ; rdfs:comment "Diffuse alveolar hemorrhage is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates." ; rdfs:label "Diffuse alveolar hemorrhage"@en ; rdfs:subClassOf obo:HP_0040223 . obo:HP_0025421 obo:IAO_0000115 "The presence of free air in the mediastinum." ; dc:date "2017-04-23T12:21:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Spontaneous pneumomediastinum (SPM) is defined as the non-traumatic presence of free air in the mediastinum in a patient with no known underlying disease. The most common etiology for SPM is alveolar rupture, most commonly due to an asthma exacerbation, but also seen with barotrauma, intrathoracic pressure increase, the valsalva maneuver, and withdrawal symptoms of illicit drugs. Other causes of pneumomediastinum include coughing, mechanical ventilation, pneumonitis, emphysema, lung fibrosis, acute respiratory distress syndrome, heroin, marijuana, cocaine use, gas producing infections in the head and neck, tracheobronchial or esophageal rupture and facial fractures that lead to disruption of maxillary sinus walls." ; rdfs:label "Pneumomediastinum"@en ; rdfs:subClassOf obo:HP_0045026 . obo:HP_0025422 obo:IAO_0000115 "A closed sac-like structure originating from the pleura that contains a liquid, gaseous, or semisolid substance." ; dc:date "2017-04-23T12:33:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pleuropericardial cysts usually are congenital anomalies. after the third week of gestation, the mesoderm separates itself to form pleural, pericardial and peritoneal spaces. Incomplete partitioning can result in a pleuropericardial cyst." ; rdfs:label "Pleural cyst"@en ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0025423 obo:IAO_0000115 "Any anomaly of the structure of the larynx." ; dc:date "2017-04-23T12:44:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal larynx morphology"@en ; rdfs:subClassOf obo:HP_0001600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025424 obo:IAO_0000115 "Any anomaly of the function of the larynx." ; dc:date "2017-04-23T12:46:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal larynx physiology"@en ; rdfs:subClassOf obo:HP_0001600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025425 obo:IAO_0000115 "A spasm (involuntary contraction) of the vocal cords that can make it difficult to speak or breathe." ; dc:date "2017-04-23T12:48:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Laryngospasm"@en ; rdfs:subClassOf obo:HP_0025424 . obo:HP_0025426 obo:IAO_0000115 "Any structural anomaly of the bronchi, i.e., of the airways leading from the trachea to the lungs." ; dc:date "2017-04-23T12:50:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0002109" ; oboInOwl:hasExactSynonym "Abnormality of the bronchi" ; a owl:Class ; rdfs:label "Abnormal bronchus morphology"@en ; rdfs:subClassOf obo:HP_0005607 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002185 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025427 obo:IAO_0000115 "Any anomaly of the function of the bronchi." ; dc:date "2017-04-23T12:51:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal bronchus physiology"@en ; rdfs:subClassOf obo:HP_0002795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002185 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025428 obo:IAO_0000115 "A spasm (sudden, involuntary constriction) of the bronchioles." ; dc:date "2017-04-23T12:52:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchospasm"@en ; rdfs:subClassOf obo:HP_0025427 . obo:HP_0025429 obo:IAO_0000115 "Any anomaly of the vocalizing of an infant's crying, i.e.,the typically loud voice production that is accompanied by tears and agitation." ; dc:date "2017-04-23T12:56:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cry"@en ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0025430 obo:IAO_0000115 "A type of crying in an abnormally high-pitched voice." ; dc:date "2017-04-23T12:59:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This type of cry may be observed with cerebral irritability due to factors such as meningitis, hydrocephalus, or kernicterus. High-pitched cry may also be observed with other conditions including Cornelia-de-Lange syndrome." ; rdfs:label "High-pitched cry"@en ; rdfs:subClassOf obo:HP_0025429 . obo:HP_0025431 obo:IAO_0000115 "A type of cry that is abnormal because it is consists of unusually shortened and detached vocalizations." ; dc:date "2017-04-23T13:07:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Staccato cry"@en ; rdfs:subClassOf obo:HP_0025429 . obo:HP_0025432 obo:IAO_0000115 "A benign epithelial skin tumor manifesting as a slightly elevated circular plaque or nodule with a red, pink or brown color and a diameter up to 22 mm." ; dc:date "2017-04-23T15:58:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acanthoma"@en ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0025433 obo:IAO_0000115 "Reduced level of the enzyme lecithin cholesterol acyl transferase." ; dc:date "2017-04-23T16:31:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C)." ; rdfs:label "Decreased lecithin cholesterol acyl transferase level"@en ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0025434 obo:IAO_0000115 "A diminished activity of the classical complement pathway as measured by the assay for 50% haemolytic complement (CH50) activity of serum." ; dc:date "2017-04-23T16:53:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced CH50" ; a owl:Class ; rdfs:comment "Individual complement components can be quantified however this does not provide any information as to the activity of the pathway. The CH50 is a screening assay for the activation of the classical complement pathway and it is sensitive to the reduction, absence and/or inactivity of any component of the pathway. The CH50 tests the functional capability of serum complement components of the classical pathway to lyse sheep red blood cells (SRBC) pre-coated with rabbit anti-sheep red blood cell antibody (haemolysin). When antibody-coated SRBC are incubated with test serum, the classical pathway of complement is activated and haemolysis results. If a complement component is absent, the CH50 level will be zero; if one or more components of the classical pathway are decreased, the CH50 will be decreased." ; rdfs:label "Reduced hemolytic complement activity"@en ; rdfs:subClassOf obo:HP_0005339 . obo:HP_0025435 obo:IAO_0000115 "An elevated level of the enzyme lactate dehydrogenase in the blood circulation." ; dc:date "2017-04-23T17:11:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased lactate dehydrogenase level" ; a owl:Class ; rdfs:comment "Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate." ; rdfs:label "Increased circulating lactate dehydrogenase concentration"@en ; rdfs:subClassOf obo:HP_0045040 . obo:HP_0025436 obo:IAO_0000115 "Increased concentration of 11-deoxycortisol in the circulation. 11-deoxycorticosterone, which is also known as simply deoxycorticosterone and 21-hydroxyprogesterone, is a steroid hormore that is produces in the adrenals and is a precursor to aldosterone." ; dc:date "2017-04-23T17:22:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated serum 21-hydroxyprogesterone", "Elevated serum deoxycorticosterone" ; a owl:Class ; rdfs:label "Elevated serum 11-deoxycortisol"@en ; rdfs:subClassOf obo:HP_0003118 . obo:HP_0025437 obo:IAO_0000115 "Increased size of the head of sperm." ; dc:date "2017-04-23T17:25:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Macrocephalic sperm head" ; a owl:Class ; rdfs:label "Macrozoospermia"@en ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0025439 obo:IAO_0000115 "Inflammation (due to infection or irritation) of the pharynx." ; dc:date "2017-04-24T00:03:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pharyngitis"@en ; rdfs:subClassOf obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025440 obo:IAO_0000115 "Warm reactive autoantibodies are RBC-directed immune responses that are maximally reactive at 37 degrees C." ; dc:date "2017-04-24T00:16:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Warm reactive antibodies react with the patients own RBCs and typically bind to all reagent or donor RBCs against which they are tested. However, they sometimes have specificity (absolute or relative) for a blood group antigen, most commonly a member of the Rh blood group system. Warm reactive autoantibodies are usually polyclonal IgG antibodies, although IgA or monomeric IgM antibodies are seen occasionally." ; rdfs:label "Warm reactive autoantibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025441 obo:IAO_0000115 "Ectopic deposition of calcium salts in the Achilles tendon." ; dc:date "2017-04-24T00:51:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Calcification of the Achilles tendon" ; a owl:Class ; rdfs:label "Achilles tendon calcification"@en ; rdfs:subClassOf obo:HP_0005109 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025443 obo:IAO_0000115 "An abnormality of the function of the cardiac atria." ; dc:date "2017-04-29T17:10:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiac atrial physiology"@en ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0025444 obo:IAO_0000115 "A decrease in the volume (size) of the amygdyla." ; dc:date "2017-04-29T21:34:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decrease in amygdala volume" ; a owl:Class ; rdfs:label "Reduced amygdala volume"@en ; rdfs:subClassOf obo:HP_0033668 . obo:HP_0025445 obo:IAO_0000115 "Any structural anomaly of the papillary muscles of the left ventricle." ; dc:date "2017-04-30T10:43:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are normally two papillary muscles. The antero-lateral papillary muscle is located in the apical third of the ventricular wall, and the postero-medial papillary muscle is located in the middle third of the ventricular wall. The antero-lateral papillary muscle is usually composed of one body or head, and the postero-medial papillary muscle usually with two bodies or heads. Each papillary muscle provides chordae to both leaflets of the mitral valve, with one of the major functions of the papillary muscles being to prevents prolapse of anterior and posterior cusps of mitral valve during systole." ; rdfs:label "Morphological abnormality of the papillary muscles"@en ; rdfs:subClassOf obo:HP_0001711 . obo:HP_0025446 obo:IAO_0000115 "A congenital malformation in which one or both of the papillary muscles (posteromedial or anterolateral) insert directly (that is, without interpositioned chordae tendineae) into the anterior mitral leaflet." ; dc:date "2017-04-30T10:50:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This malformation consists of a direct continuity between a hypertrophied papillary muscle and the anterior mitral leaflet (Normally, the papillary muscle is connected to the leaflet via the chordae tendinae). Themalformation can be identified echocardiographically. It results in a long rigid area of mid-cavity narrowing that in turn can cause left ventricular outflow tract obstruction." ; rdfs:label "Anomalous insertion of papillary muscle directly into anterior mitral leaflet"@en ; rdfs:subClassOf obo:HP_0025445 . obo:HP_0025447 obo:IAO_0000115 "Abnormal location of the insertion of a papillary muscle into the left ventricular wall." ; dc:date "2017-04-30T10:59:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Displacement of the papillary muscles"@en ; rdfs:subClassOf obo:HP_0025445 . obo:HP_0025448 obo:IAO_0000115 "Abnormally anterior location of the papillary muscles of the left ventricle." ; dc:date "2017-04-30T11:00:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anteriorly displaced papillary muscles" ; a owl:Class ; rdfs:comment "Possible mechanisms for systolic anterior motion with anterior displacement of the papillary muscles (PM): (1) the normal posterior component of PM tension is reduced by anterior displacement of the muscle tips; (2) interposing the leaflets into the streamlines of flow causes drag forces with an anterior component; and (3) pulling up the posterior leaflet so that it meets the anterior leaflet closer to its base creates a long, overlapping residual leaflet, as seen clinically. This leaflet portion is relatively free to move anteriorly, unlike the coapted leaflet bodies that are restrained by the balance of ventricular and atrial pressures acting across them. The angle between the posterior leaflet and posterior wall is increased [PMID:7850958]." ; rdfs:label "Anterior displacement of the papillary muscles"@en ; rdfs:subClassOf obo:HP_0025447 . obo:HP_0025449 obo:IAO_0000115 "Abnormal location of the insertion of the anterolateral papillary muscle near to the apex of the left ventricle. This feature may be appreciated by noting that this muscle is usually not seen in the apical level of the parasternal short-axis echocardiographic view," ; dc:date "2017-04-30T11:02:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Apically displaced papillary muscles" ; a owl:Class ; rdfs:label "Apically displaced anterolateral papillary muscle"@en ; rdfs:subClassOf obo:HP_0025447 . obo:HP_0025451 obo:IAO_0000115 "Testicular adrenal rest tumor (TART) is a abenign tumor of the testis. TART generally occurs multiply and bilaterally within the rete testis. Histologically, TART resemble adrenocortical tissue, which led to the name. The tumous are not encapsulated and consist of sheets or confluent cords of large polygonal cells with abundant eosinophilic cytoplasm." ; dc:date "2017-05-04T10:21:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Testicular adrenal rest tumour" ; a owl:Class ; rdfs:label "Testicular adrenal rest tumor"@en ; rdfs:subClassOf obo:HP_0010788 . obo:HP_0025452 obo:IAO_0000115 "A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer." ; dc:date "2017-05-04T10:30:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pyoderma gangrenosum can occur on any skin surface, but is most commonly seen on the legs. Patients are often systemically unwell with symptoms such as fever, malaise, arthralgia, and myalgia. Lesions are usually painful and the pain can be severe. When the lesions heal the scars are often cribriform. About half of the cases are associated with underlying systemic conditions, such as inflammatory bowel disease, arthritis, and haematological malignancies." ; rdfs:label "Pyoderma gangrenosum"@en ; rdfs:subClassOf obo:HP_0200042 . obo:HP_0025453 obo:IAO_0000115 "Occurence of adrenarche at a later than normal age. Adrenarche normally occurs between six and eight years of age with increased adrenal androgen secretion; its exact biologic role is not well understood. It is accompanied by changes in pilosebaceous units, a transient growth spurt and the appearance of axillary and pubic hair in some children, but no sexual development." ; dc:date "2017-05-04T10:41:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed adrenarche"@en ; rdfs:subClassOf obo:HP_0000823 . obo:HP_0025454 obo:IAO_0000115 "Any deviation from the normal range of concentration of a metabolite in the cerebrospinal fluid." ; dc:date "2017-05-05T10:24:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032207" ; oboInOwl:hasExactSynonym "Abnormal CSF metabolite level", "Abnormal cerebrospinal fluid metabolite concentration" ; a owl:Class ; rdfs:label "Abnormal CSF metabolite concentration"@en ; rdfs:subClassOf obo:HP_0001939, obo:HP_0002921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_25212 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025455 obo:IAO_0000115 "5-HIAA (5-hydroxyindolacetic acid) concentration in the cerebrospinal fluid (CSF) is below the lower limit of normal." ; dc:date "2017-05-05T10:26:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased CSF 5-HIAA", "Low CSF 5-HIAA", "Low CSF 5-hydroxyindolacetic acid" ; a owl:Class ; rdfs:label "Decreased CSF 5-hydroxyindolacetic acid concentration"@en ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0025456 obo:IAO_0000115 "Any deviation from the normal range of a protein concentration in the cerebrospinal fluid." ; dc:date "2017-05-05T10:32:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CSF protein level" ; a owl:Class ; rdfs:label "Abnormal CSF protein concentration"@en ; rdfs:subClassOf obo:HP_0001939, obo:HP_0002921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025457 obo:IAO_0000115 "CSF total protein level is below the lower limit of normal." ; dc:date "2017-05-05T10:34:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased CSF protein", "Decreased cerebrospinal fluid total protein", "Hypoproteinorrhachia", "Low CSF total protein" ; a owl:Class ; rdfs:label "Decreased CSF protein concentration"@en ; rdfs:subClassOf obo:HP_0025456 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025458 obo:IAO_0000115 "CSF albumin level is below the lower limit of normal." ; dc:date "2017-05-05T10:46:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low CSF albumin" ; a owl:Class ; rdfs:label "Decreased CSF albumin concentration"@en ; rdfs:subClassOf obo:HP_0500238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025459 obo:IAO_0000115 "An increase above normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration." ; dc:date "2017-05-05T10:50:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased CSF/serum albumin ratio"@en ; rdfs:subClassOf obo:HP_0030981 . obo:HP_0025460 obo:IAO_0000115 "An elevated level of myoinositol in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2017-05-05T10:59:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High myo-inositol in brain by MRS" ; a owl:Class ; rdfs:comment "Myo-Inositol (MI) is one of the most abundant metabolites in the human brain located mainly in glial cells and functions as an osmolyte. The concentration of MI is altered in many brain disorders including Alzheimer's disease and brain tumors." ; rdfs:label "High myoinositol in brain by MRS"@en ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0025461 obo:IAO_0000115 "Any anomaly of cell structure." ; dc:date "2017-05-07T11:14:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cell morphology"@en ; rdfs:subClassOf obo:HP_0025354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025462 obo:IAO_0100001 "HP:0011017" ; dc:date "2017-05-07T11:16:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "obsolete Abnormal cellular physiology"@en ; owl:deprecated true . obo:HP_0025463 obo:IAO_0000115 "An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions." ; dc:date "2017-05-07T11:17:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of redox activity"@en ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0051341 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025464 obo:IAO_0000115 "An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage." ; dc:date "2017-05-07T11:19:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased ROS production" ; oboInOwl:hasRelatedSynonym "Oxidative stress" ; a owl:Class ; rdfs:label "Increased reactive oxygen species production"@en ; rdfs:subClassOf obo:HP_0025463 . obo:HP_0025465 obo:IAO_0000115 "A deviation from the normal concentration of beta globulin. The beta globulins are a group of globular (globe-shaped) proteins in blood." ; dc:date "2017-05-07T11:35:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The name beta globulin comes from the fact that protein electrophoresis of serum proteins results in a characteristic pattern of albumins, alpha, beta, and gamma globulins." ; rdfs:label "Abnormal circulating beta globulin level"@en ; rdfs:subClassOf obo:HP_0032179 . obo:HP_0025466 obo:IAO_0000115 "Increased level of beta 2-microglobulins in the urine." ; dc:date "2017-05-07T11:50:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Beta 2-microglobulinuria"@en ; rdfs:subClassOf obo:HP_0020129 . obo:HP_0025469 obo:IAO_0000115 "An abnormal loss of anagen (growth phase) hairs." ; dc:date "2017-05-14T11:20:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anagen effluvium is the result of a disturbance of proliferative activity of hair follicle matrix cells, which leads to the narrowing and subsequent breakage of the proximal portion of hair shafts. This type of hair loss can be caused by systemic chemotherapy or by radiotherapy to the head." ; rdfs:label "Anagen effluvium"@en ; rdfs:subClassOf obo:HP_0011362 . obo:HP_0025470 obo:IAO_0000115 "A type of hair loss characterized by an abnormal increase in dormant, telogen stage hair follicles." ; dc:date "2017-05-14T11:23:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Telogen effluvium"@en ; rdfs:subClassOf obo:HP_0011362 . obo:HP_0025471 obo:IAO_0000115 "A hamartomatous proliferation containing malformed hair follicles in various stages of development. Panfolliculomas are well-circumscribed lesions demonstrating all stages of follicular differentiation." ; dc:date "2017-05-14T11:57:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Congenital panfollicular nevus"@en ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0025472 obo:IAO_0000115 "A history of repeated fungal infections located on the sole of the foot, usually manifested by scaling, maceration, and itching." ; dc:date "2017-05-14T12:31:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent plantar mycosis"@en ; rdfs:subClassOf obo:HP_0002841 . obo:HP_0025473 obo:IAO_0000115 "A papule (circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point) that exhibits increased pigmentation (is darker) compared to the surrounding skin." ; dc:date "2017-05-14T12:34:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperpigmented papule"@en ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0025474 obo:IAO_0000115 "A plaque (a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter) with a red or reddish color often associated with inflammation or irritation." ; dc:date "2017-05-14T12:38:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Violaceous plaque" ; a owl:Class ; rdfs:label "Erythematous plaque"@en ; rdfs:subClassOf obo:HP_0200035 . obo:HP_0025475 obo:IAO_0000115 "A macule (flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin) with a red or reddish color often associated with inflammation or irritation." ; dc:date "2017-05-14T12:43:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Numerous tones of red ranging from pink to violaceous are subsumed under the category of erythematous." ; rdfs:label "Erythematous macule"@en ; rdfs:subClassOf obo:HP_0012733 . obo:HP_0025476 obo:IAO_0000115 "Multiple foci of adipocytes within the testicular interstitium, usually presenting as multiple bilateral ill-defined hyperechoic intratesticular lesions of different sizes but generally with maximum diameter of 4 mm." ; dc:date "2017-05-14T12:49:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Testicular lipomatosis may be a sign of Cowden disease." ; rdfs:label "Testicular lipomatosis"@en ; rdfs:subClassOf obo:HP_0000035, obo:HP_0001012 . obo:HP_0025477 obo:IAO_0000115 "Calcified deposits in soft tissue structures outside a joint." ; dc:date "2017-05-14T13:23:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periarticular calcification"@en ; rdfs:subClassOf obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0025478 obo:IAO_0000115 "Atrial standstill or silent atrium is a rare condition presenting with the absence of electrical and mechanical activity in the atria. It presents with the absence of P waves, bradycardia, and wide QRS complex in the electrocardiogram." ; dc:date "2017-05-14T13:28:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Silent atrium" ; a owl:Class ; rdfs:label "Atrial standstill"@en ; rdfs:subClassOf obo:HP_0005115 . obo:HP_0025479 obo:IAO_0000115 "Neglecting one's own needs and well-being." ; dc:date "2017-05-14T13:39:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Self-neglect"@en ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0025480 obo:IAO_0000115 "A type of spinal dysraphism presenting as a subcutaneous fatty mass, that is, a spinal defect associated with lipomatous tissue, and covered by skin. The most usual location for lipomyelomeningocele is at the gluteal cleft."@en ; dc:date "2017-05-14T13:52:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lipomyelomeningocele" ; rdfs:subClassOf obo:HP_0002475, obo:HP_0034238 . obo:HP_0025481 obo:IAO_0000115 "Absence of one half of the vertebral body in the cervical spine." ; dc:date "2017-05-14T13:58:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cervical hemivertebrae"@en ; rdfs:subClassOf obo:HP_0002937 . obo:HP_0025482 obo:IAO_0000115 "An abnormal result of the perchlorate discharge test. In this test, first radioactive iodine is administered, sufficient time is allowed to pass so that the radioactive iodine is captured by the thyroid,and then, perchlorate is administered orally. The perchlorate displaces non-organified iodide from the thyroid. The perchlorate discharge test is considered positive (abnormal) if there is an abnormally rapid loss of radioactive iodine from the thyroid." ; dc:date "2017-05-14T16:04:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Individuals with Pendred syndrome may show a positive perchlorate discharge test." ; rdfs:label "Positive perchlorate discharge test"@en ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0025483 obo:IAO_0000115 "A deviation from the normal concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones." ; dc:date "2017-05-14T16:14:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating thyroglobulin level"@en ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0025484 obo:IAO_0000115 "An abnormal elevation of the concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones." ; dc:date "2017-05-14T16:15:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating thyroglobulin level"@en ; rdfs:subClassOf obo:HP_0025483 . obo:HP_0025485 obo:IAO_0000115 "Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life." ; dc:date "2017-05-14T16:40:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Spontaneous vaginal adenosis appears to be a fairly common (present in about 10% of adult women) but mostly insignificant coincidental finding. In women prenatally exposed to diethylstilboestrol (DES), vaginal adenosis may arise in up to 90% and is associated with a high risk of vaginal carcinoma." ; rdfs:label "Vaginal adenosis"@en ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0025486 obo:IAO_0000115 "The outer labia are sealed together." ; dc:date "2017-05-14T17:00:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fused labia majora"@en ; rdfs:subClassOf obo:HP_0012881 . obo:HP_0025487 obo:IAO_0000115 "Any structural anomaly of the bladder." ; dc:date "2017-05-14T17:07:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of bladder morphology"@en ; rdfs:subClassOf obo:HP_0000014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025488 obo:IAO_0000115 "A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation." ; dc:date "2017-05-14T17:09:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Detrusor sphincter dyssynergia (DSD) is associated with neurologic conditions such as spinal cord injury, multiple sclerosis, and spina bifida and some of these neurogenic bladder patients with DSD may be at risk for autonomic dysreflexia, recurrent urinary tract infections, or upper tract compromise if the condition is not followed and treated appropriately. It is diagnosed most commonly during the voiding phase of urodynamic studies using EMG recordings and voiding cystourethrograms, although urethral pressure monitoring could also potentially be used." ; rdfs:label "Detrusor sphincter dyssynergia"@en ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0025489 obo:IAO_0000115 "A congenital anomaly characterized by the presence of two bladders." ; dc:date "2017-05-14T17:16:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bladder duplication"@en ; rdfs:subClassOf obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025490 obo:IAO_0000115 "A congenital variant of a coronary artery in which a portion of an epicardial coronary artery (most frequently the middle segment of the left anterior descending artery) takes an intramuscular course." ; dc:date "2017-05-14T19:08:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intramyocardial coronary artery course" ; a owl:Class ; rdfs:comment "Myocardial bridging, in which a tunneled segment of the artery under the bridge of overlying myocardium frequently results in vessel compression during systole. While frequently asymptomatic, this condition in many cases may be responsible for adverse complications including angina, myocardial ischemia, acute coronary syndromes, left ventricular dysfunction, arrhythmias, and even sudden cardiac death." ; rdfs:label "Myocardial bridging"@en ; rdfs:subClassOf obo:HP_0011686 . obo:HP_0025491 obo:IAO_0000115 "Narrowing of a vein due to intimal hyperplasia and fibrosis." ; dc:date "2017-05-14T19:22:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Venous stenosis can be secondary to placement of central venous catheters, pacemaker leads, hemodialysis catheters, prior radiation, trauma, or extrinsic compression by musculoskeletal structures." ; rdfs:label "Venous stenosis"@en ; rdfs:subClassOf obo:HP_0002624 . obo:HP_0025492 obo:IAO_0000115 "A small pupil (typically diameter less than 2 mm) that dilates poorly or not at all in response to topically administered mydriatic drugs." ; dc:date "2017-05-14T19:32:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Microcoria"@en ; rdfs:subClassOf obo:HP_0000615, obo:HP_0007700 . obo:HP_0025493 obo:IAO_0000115 "Redness of the skin of the palm of the hand and the sole of the foot caused by hyperemia of the capillaries in the lower layers of the skin." ; dc:date "2017-05-14T19:34:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palmoplantar erythema"@en ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0025494 obo:IAO_0000115 "Regular circumferential periaortic fibrosis involving the whole aorta and leading to a coated aorta appearance on computed tomography scans" ; dc:date "2017-05-14T19:37:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is characteristic of Erdheim Chester disease." ; rdfs:label "Coated aorta"@en ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0025495 obo:IAO_0000115 "Significant luminal narrowing of a long segment of the descending aorta." ; dc:date "2017-05-14T19:49:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Coarctation of the aorta is defined as significant luminal narrowing of the aorta that produces hemodynamically significant obstruction to the flow of blood. This process may affect a short isolated segment of the aorta or a longer and more diffuse segment. When longer segments of the aorta are narrowed, the term hypoplasia is often used. Much less common than segmental coarctation, aortic hypoplasia has been described in all portions of the thoracic and abdominal aorta." ; rdfs:label "Descending aorta hypoplasia"@en ; rdfs:subClassOf obo:HP_0031934 . obo:HP_0025496 obo:IAO_0000115 "Any anomaly of the function of a coronary artery." ; dc:date "2017-05-14T19:58:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal coronary artery physiology"@en ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0025497 obo:IAO_0000115 "A brief and sudden narrowing of a coronary artery." ; dc:date "2017-05-14T19:58:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coronary artery vasospasm" ; a owl:Class ; rdfs:comment "Severe chest pain, usually without physical effort and with a concurrent ECG showing transient ST elevation, is the key for the diagnosis of coronary artery spasm." ; rdfs:label "Coronary artery spasm"@en ; rdfs:subClassOf obo:HP_0025496 . obo:HP_0025498 obo:IAO_0000115 "Absence of ceruloplasmin in the blood." ; dc:date "2017-05-14T20:03:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aceruloplasminaemia" ; a owl:Class ; rdfs:label "Aceruloplasminemia"@en ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0025499 obo:IAO_0000115 "Obesity with a body mass index of 30 to 34.9 kg per square meter." ; dc:date "2017-05-14T20:06:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Obesity grade 1" ; a owl:Class ; rdfs:label "Class I obesity"@en ; rdfs:subClassOf obo:HP_0001513 . obo:HP_0025500 obo:IAO_0000115 "Obesity with a body mass index of 35 to 39.9 kg per square meter." ; dc:date "2017-05-14T20:08:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Obesity grade 2" ; a owl:Class ; rdfs:label "Class II obesity"@en ; rdfs:subClassOf obo:HP_0001513 . obo:HP_0025501 obo:IAO_0000115 "Obesity with a body mass index of 40 kg per square meter or higher." ; dc:date "2017-05-14T20:09:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Obesity grade 3" ; a owl:Class ; rdfs:label "Class III obesity"@en ; rdfs:subClassOf obo:HP_0001513 . obo:HP_0025502 obo:IAO_0000115 "Increased body weight with a body mass index of 25-29.9 kg per square meter." ; dc:date "2017-05-14T20:12:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Overweight"@en ; rdfs:subClassOf obo:HP_0004324 . obo:HP_0025503 obo:IAO_0000115 "Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva." ; dc:date "2017-05-14T22:28:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are three sinus in the wall of the aorta just superior to the aortic semilunar valve. The right coronary artery normally arises from the right sinus of Valsalva (RSV) of the ascending aorta. The left main coronary artery (LMCA) normally arises from the left sinus of Valsava. The third sinus, the right posterior aortic sinus does not normally give rise to a coronary artery." ; rdfs:label "Anomalous coronary artery arising from the opposite sinus"@en ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0025505 obo:IAO_0000115 "The circumflex coronary artery originates from the right aortic sinus of Valsalva." ; dc:date "2017-05-14T23:16:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of the circumflex artery from the right sinus of Valsalva"@en ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0025506 obo:IAO_0000115 "Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva, with the additional feature that the artery passes between the two great arteries. This carries a risk of the artery being compressed by these two vessels," ; dc:date "2017-05-14T23:20:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anomalous coronary artery with aortic origin and course between the great arteries" ; a owl:Class ; rdfs:comment "Further synonyms include Anomalous origin of the coronary artery from the opposite sinus of Valsalva with an interarterial course and Anomalous origin of the coronary artery from the wrong sinus of Valsalva with a proximal course between the aorta and pulmonary artery" ; rdfs:label "Coronary artery sandwich anomaly"@en ; rdfs:subClassOf obo:HP_0025503 . obo:HP_0025507 obo:IAO_0000115 "A papule with yellow color." ; dc:date "2017-05-14T23:29:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Yellow-orange papule" ; a owl:Class ; rdfs:comment "The yellow color may be related to lipid accumulation such as xanthomata or sebaceous gland lesions. This term additionally includes lesions described as yellow-orange." ; rdfs:label "Yellow papule"@en ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0025508 obo:IAO_0000115 "Violaceous papules overlying the dorsal and lateral aspects of the metacarpophalangeal and proximal interphalangeal joints." ; dc:date "2017-05-14T23:39:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gottron papules" ; a owl:Class ; rdfs:label "Gottron's papules"@en ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0025509 obo:IAO_0000115 "Flesh-colored or yellowish papules, 2 mm or larger, that are responses to internal mechanical pressure and weakness in the connective tissue in the dermis, appear commonly over the medial aspect of the heel, but in some cases on the wrists. They are thought to represent herniations of adipose tissue through the plantar fascia retinaculum." ; dc:date "2017-05-14T23:43:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Piezogenic pedal papules"@en ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0025510 obo:IAO_0000115 "A tan, regularly bordered patch with darker macules within the lesion." ; dc:date "2017-05-15T00:49:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Speckled lentiginous Nevus" ; a owl:Class ; rdfs:label "Nevus spilus"@en ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0025511 obo:IAO_0000115 "A solitary yellow-orange slightly raised plaque typically on scalp or face. The plaque typically thickens and becomes more verrucous or pebbly during childhood." ; dc:date "2017-05-15T00:51:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nevus sebaceus"@en ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0025512 obo:IAO_0000115 "A papule with the same color as the surrounding skin." ; dc:date "2017-05-15T01:07:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flesh-colored papule" ; a owl:Class ; rdfs:label "Skin-colored papule"@en ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0025513 obo:IAO_0000115 "Breakage of the sclera." ; dc:date "2017-05-15T01:54:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Scleral rupture may occur following trauma or may be observed with some types of Ehlers Danlos syndrome and other disorders. The rupture may be hidden by an intact conjunctiva." ; rdfs:label "Scleral rupture"@en ; rdfs:subClassOf obo:HP_0000591 . obo:HP_0025514 obo:IAO_0000115 "An abnormality of the optic nerve in which the optic nerve is large and funneled and displays a conical excavation of the optic disc. The optic disc appears dysplastic." ; dc:date "2017-05-15T02:00:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Morning glory disc anomaly", "Morning glory optic disc" ; a owl:Class ; rdfs:comment "The name of this anomaly derives from a perceived similarity of the anomaly to the morning glory flower." ; rdfs:label "Morning glory anomaly"@en ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0025515 obo:IAO_0000115 "Later than normal development of the breasts." ; dc:date "2017-05-15T02:12:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed thelarche"@en ; rdfs:subClassOf obo:HP_0000823 . obo:HP_0025516 obo:IAO_0000115 "A congenital malformation with abnormal connection between one of the coronary arteries and the pulmonary artery." ; dc:date "2017-05-16T01:14:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coronary-pulmonary artery fistula"@en ; rdfs:subClassOf obo:HP_0011641 . obo:HP_0025517 obo:IAO_0000115 "Underdevelopment of the hippocampus." ; dc:date "2017-05-16T22:42:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Small hippocampus", "Underdeveloped hippocampus" ; a owl:Class ; rdfs:label "Hypoplastic hippocampus"@en ; rdfs:subClassOf obo:HP_0025100 . obo:HP_0025518 obo:IAO_0000115 "An abnormality of gaze that can be observed following an acute supranuclear cerebral lesion (e.g., stroke) that is characterized by an acute inability to direct gaze contralateral to the side of the lesion and is accompanied by a tendency for tonic deviation of the eyes toward the side of the lesion." ; dc:date "2017-05-17T01:15:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "With visual gaze preference due to an acute supranuclear cerebral lesion, the oculocephalic reflex (which can be elicited by the so called Doll's head manoeuvre) is intact. The head is briskly turned from side to side with the head held briefly at the end of each turn. If the brainstem and infranuclear pathways are intact, then the eyes rotate to the opposite side to the direction of head rotation. Stroke is the most common etiology of this finding." ; rdfs:label "Visual gaze preference"@en ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0025519 obo:IAO_0000115 "Multiple biliary hamartomas are a rare clinicopathologic entity, consisting of small (less than 1.5cm), usually multiple and nodular cystic lesions in the liver." ; dc:date "2017-05-17T12:34:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multiple bile duct hamartomas", "Von Meyenburg complexes" ; oboInOwl:hasRelatedSynonym "Biliary hamartoma" ; a owl:Class ; rdfs:comment "Multiple biliary hamartomas are part of the wider spectrum of ductal plate malformation where there is congenital malformation of the biliary duct. Multiple biliary hamartomas can be diagnosed using magnetic resonance imaging which shows multiple hyper-intense cystic nodules not communicating with the biliary tree. The diagnosis can be confirmed on liver histology. Multiple biliary hamartomas are usually an incidental finding without symptoms. There have been rare associations with development of cholangiocarcinoma." ; rdfs:label "Multiple biliary hamartomas"@en ; rdfs:subClassOf obo:HP_0100574 . obo:HP_0025520 obo:IAO_0000115 "Deposition of calcium in the skin." ; dc:date "2017-05-17T22:39:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cutaneous calcification" ; a owl:Class ; rdfs:comment "The lesions observed incalcinosis cutis are firm papules, plaues, or nodules that have a whitish or yellowish color. Lesions may be solitary but it is more common to observe multiple lesions. The lesions may develop ulceration with a discharge of a chalk-like substance. The lesions can be painful, espcially if they are located on the fingertips. Lesions at other sites may limit joint mobility or stiffen the skin." ; rdfs:label "Calcinosis cutis"@en ; rdfs:subClassOf obo:HP_0010766 . obo:HP_0025521 obo:IAO_0000115 "The percentage of fat as a part of total body weight above the norm, usually defined as 32% for females and 25% for males." ; dc:date "2017-05-17T22:56:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased body fat percentage"@en ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0025522 obo:IAO_0000115 "Abnormal increased in length of the chordae tendinae of the mitral valve." ; dc:date "2017-05-17T23:42:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elongated chordae tendinae of the mitral valve"@en ; rdfs:subClassOf obo:HP_0025523 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014851 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025523 obo:IAO_0000115 "A structural anomaly of the chordae tendinae of the mitral valve, whose main function is to transmit the contraction and relaxation of the papillary muscles during the cardiac cycle, thus ensuring the closing of the leaflets of the mitral valve." ; dc:date "2017-05-17T23:44:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of the chordae tendinae of the mitral valve"@en ; rdfs:subClassOf obo:HP_0001633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014851 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025524 obo:IAO_0000115 "Loss of the outer layer of the epidermis in large, scale-like flakes localized to the palm of the hand and the sole of the foot." ; dc:date "2017-05-17T23:50:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Palmoplantar psoriasis" ; a owl:Class ; rdfs:label "Palmoplantar scaling skin"@en ; rdfs:subClassOf obo:HP_0040189 . obo:HP_0025525 obo:IAO_0000115 "Loss of the outer layer of the epidermis in large, scale-like flakes localized to one or more fingertips." ; dc:date "2017-05-17T23:53:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Scaling skin on fingertip"@en ; rdfs:subClassOf obo:HP_0040189 . obo:HP_0025526 obo:IAO_0000115 "A skin lesions that resembles the lesions observed in psoriasis, viz., an erythematous plaque covered by fine silvery scales. Psoriasiform lesions can be observed in psoriasis as well as in other conditions including allergic contact dermatitis, seborrhoeic dermatitis, Atopic dermatitis, pityriasis rubra, and lichen simplex chronicus." ; dc:date "2017-05-17T23:58:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Psoriatic-like lesion" ; oboInOwl:hasRelatedSynonym "Erythemato-squamous plaque", "Erythematosquamous plaque" ; a owl:Class ; rdfs:label "Psoriasiform lesion"@en ; rdfs:subClassOf obo:HP_0040189 . obo:HP_0025527 obo:IAO_0000115 "A skin lesion with a snake- or serpent-like distribution." ; dc:date "2017-05-18T00:05:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Serpiginous eruption" ; a owl:Class ; rdfs:label "Serpiginous cutaneous lesion"@en ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0025528 obo:IAO_0000115 "A lesion of the skin with a ring-like distribution." ; dc:date "2017-05-18T00:14:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Annular cutaneous lesion"@en ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0025529 obo:IAO_0000115 "A nodule of the skin that exhibits an increased amount of pigmentation." ; dc:date "2017-05-18T00:19:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperpigmented nodule"@en ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0025530 obo:IAO_0000115 "The presence of multiple xanthomas (xanthomata) in the skin distributed in the creases of the palm of the hand. Xanthomas are yellowish, firm, lipid-laden nodules in the skin." ; dc:date "2017-05-18T00:34:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Xanthoma palmare striatum", "Xanthoma striatum palmare" ; a owl:Class ; rdfs:label "Xanthomas of the palmar creases"@en ; rdfs:subClassOf obo:HP_0000991 . obo:HP_0025531 obo:IAO_0000115 "The Harlequin phenomenon consists of a sudden change in skin colour, resulting in two different body colours, one on each half of the body." ; dc:date "2017-05-18T00:38:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The Harlequin phenomenon (HF) is most common in the newborn and can be a generalized phenomenon or only involve a specific body area. The HF of the newborn is thought to be secondary to a relative hypothalamic control immaturity of the sympathetic peripheral vascular tonus, although it has also been described in other age groups, primarily located to the face and neck and mostly caused by a sympathetic disautonomy. While certainly peculiar, the HF is a benign event in the newborn." ; rdfs:label "Harlequin phenomenon"@en ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0025532 obo:IAO_0000115 "With the pathergy test, a small, sterile needle is inserted into the skin of the forearm. The site of injectionis circuled and observed after one and two days. If a small red bump or pustule at the site of needle insertion occurs, the pathergy test is considered to have a positive (abnormal) result." ; dc:date "2017-05-18T00:41:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A positive pathergy test indicates the immune system is overreacting to a minor injury. A positive test result can be seen in Behcet disease and other conditions." ; rdfs:label "Positive pathergy test"@en ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0025533 dc:date "2017-05-18T01:05:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A swelling of the skin in which the skin is tethered by the sweat ducts it contains producing tiny dimples. THe overall appearance is said to resemble the skin (peal) of an orange." ; rdfs:label "Peau d'orange"@en ; rdfs:subClassOf obo:HP_0000969 . obo:HP_0025534 obo:IAO_0000115 "A congenital lesion of the sclera characterized by unilateral patchy but extensive slate-gray or bluish discoloration of the sclera . The conjunctiva are spared." ; dc:date "2017-05-18T01:13:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Melanosis oculi", "Ocular melanosis" ; a owl:Class ; rdfs:comment "In ocular melanocytosis, Intraocular pigmentation is also increased, which contributes to a higher incidence of glaucoma and increases the risk of malignant melanoma." ; rdfs:label "Ocular melanocytosis"@en ; rdfs:subClassOf obo:HP_0000591 . obo:HP_0025535 obo:IAO_0000115 "Erythematous, poikilodermatous macules distributed in a shawl pattern over the shoulders, arms and upper back." ; dc:date "2017-05-18T01:20:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature may be observed with dermatomyositis and polymyositis." ; rdfs:label "Shawl sign"@en ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0025536 obo:IAO_0000115 "Erythematous, poikilodermatous macules distributed in a V-shaped distribution over the anterior neck and chest." ; dc:date "2017-05-18T01:20:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature may be observed with dermatomyositis and polymyositis." ; rdfs:label "V-sign"@en ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0025537 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin on sole of the foot." ; dc:date "2017-05-18T01:29:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Plantar oedema" ; a owl:Class ; rdfs:label "Plantar edema"@en ; rdfs:subClassOf obo:HP_0100872 . obo:HP_0025538 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin on the palm of the hand." ; dc:date "2017-05-18T01:30:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Palmar oedema" ; a owl:Class ; rdfs:label "Palmar edema"@en ; rdfs:subClassOf obo:HP_0040211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025539 dc:date "2017-06-12T15:24:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal B cell subset distribution"@en ; rdfs:subClassOf obo:HP_0010975 . obo:HP_0025540 obo:IAO_0000115 "Any abnormality in the proportion T cells subsets relative to the total number of T cells." ; dc:date "2017-06-12T15:27:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal T cell subset distribution"@en ; rdfs:subClassOf obo:HP_0011839 . obo:HP_0025541 dcterms:creator ; oboInOwl:consider "HP:0005339" ; a owl:Class ; rdfs:label "obsolete Decreased activity of complement receptor"@en ; owl:deprecated true . obo:HP_0025546 obo:IAO_0000115 "A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced." ; dc:date "2017-07-09T12:25:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal MCH", "Abnormal MCHC", "Abnormal mean corpuscular Hb concentration", "Abnormal mean corpuscular haemoglobin", "Abnormal mean corpuscular haemoglobin concentration" ; a owl:Class ; rdfs:label "Abnormal mean corpuscular hemoglobin concentration"@en ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0025547 obo:IAO_0000115 "A reduction from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced." ; dc:date "2017-07-09T12:28:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased MCH", "Decreased MCHC", "Decreased mean corpuscular Hb concentration", "Decreased mean corpuscular haemoglobin", "Decreased mean corpuscular haemoglobin concentration" ; a owl:Class ; rdfs:label "Decreased mean corpuscular hemoglobin concentration"@en ; rdfs:subClassOf obo:HP_0025546 . obo:HP_0025548 obo:IAO_0000115 "An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell)." ; dc:date "2017-07-09T12:29:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased MCH", "Increased MCHC", "Increased mean corpuscular Hb concentration", "Increased mean corpuscular haemoglobin", "Increased mean corpuscular haemoglobin concentration" ; a owl:Class ; rdfs:label "Increased mean corpuscular hemoglobin concentration"@en ; rdfs:subClassOf obo:HP_0025546 . obo:HP_0025549 obo:IAO_0000115 "A uniocular condition in which there is fixation of an object by a point other than the fovea. This point adopts the principal visual direction. The degree of the eccentric fixation is defined by its distance from the fovea in degrees." ; dc:date "2017-07-09T12:48:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eccentric fixation" ; a owl:Class ; rdfs:comment "A anomaly in which a part of the retina other than the fovea is used for visual fixation. The fovea usually retains its straight ahead orientation. Eccentric fixation may be present under conditions of viewing with one or both eyes. However, it is more easily diagnosed monocularly (especially if the better eye is covered)." ; rdfs:label "Eccentric visual fixation"@en ; rdfs:subClassOf obo:HP_0025404 . obo:HP_0025550 obo:IAO_0000115 "An increase above the normal concentration of ribitol in the blood." ; dc:date "2017-07-09T13:01:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of ribitol in serum" ; a owl:Class ; rdfs:label "Elevated circulating ribitol concentration"@en ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15963 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025551 obo:IAO_0000115 "Abnormal decussation of the visual pathways, typically identified using visual evoked potentials (VEP) (asymmetrical distribution of the VEP over the posterior scalp)." ; dc:date "2017-07-09T13:10:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Optic pathway misrouting", "Visual pathway misrouting" ; a owl:Class ; rdfs:label "Optic nerve misrouting"@en ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0025552 obo:IAO_0000115 "Multiple red/purple spots on the skin that surrounds the eyes that do not blanch (whiten) upon pressure. Purpura is caused by subcutaneous bleeding." ; dc:date "2017-07-09T13:14:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periorbital purpura"@en ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0025553 obo:IAO_0000115 "Subcutaneous bleeding with a diameter greater than 1 cm (ecchymosis). The bleeding does not extend into the tarsal plate (the comparatively thick, elongated plates of dense connective tissue within the eyelid) due to an anatomic structure called the orbital septum, which limits extravasation of blood beyond the tarsal plate." ; dc:date "2017-07-09T13:16:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Raccoon eyes" ; a owl:Class ; rdfs:label "Periorbital ecchymosis with tarsal plate sparing"@en ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0025554 obo:IAO_0000115 "A type of skin nodule (a lesions that is greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat) with a yellowish coloration (that reflects a high lipid content of the lesion)." ; dc:date "2017-07-09T13:41:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Yellow nodule"@en ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0025555 obo:IAO_0000115 "Telangiectasia (small dilated blood vessels) located near to the fingernails or toenails." ; dc:date "2017-07-09T13:50:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periungual teleangiectasia"@en ; rdfs:subClassOf obo:HP_0100585 . obo:HP_0025558 obo:IAO_0000115 "Lamellar cataracts with associated linear lens opacities radially extending towards the periphery of the lens." ; dc:date "2017-12-13T12:54:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lamellar cataract with riders"@en ; rdfs:subClassOf obo:HP_0007971 . obo:HP_0025559 obo:IAO_0000115 "A type of cataract characterised by club-shaped and dot opacities distributed radially in the deep cortex. These lens opacities surround the nucleus in an appearance that is though to resemble a crown." ; dc:date "2017-12-13T13:04:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coronary cataract"@en ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0025560 obo:IAO_0000115 "Tiny deposits corresponding to cells floating in the anterior chamber of the eye. This appearance is typically associated with intraocular inflammation leading to breakdown of the blood-aqueous barrier and resulting in an increase in the number of cells and in the aqueous humor. Grading (SUN Working Group) is performed by estimating the number of cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:00:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells"@en ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0025561 obo:IAO_0000115 "Anterior chamber cells with 6-15 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:15:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 1+"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025562 obo:IAO_0000115 "Anterior chamber cells with 1-5 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:17:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 0.5+"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025563 obo:IAO_0000115 "Anterior chamber cells with less than one cell in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:19:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 0"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025564 obo:IAO_0000115 "Anterior chamber cells with 16-25 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:21:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 2+"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025565 obo:IAO_0000115 "Anterior chamber cells with 26-50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:23:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 3+"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025566 obo:IAO_0000115 "Anterior chamber cells with more than 50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." ; dc:date "2017-12-14T13:24:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber cells grade 4+"@en ; rdfs:subClassOf obo:HP_0025560 . obo:HP_0025567 obo:IAO_0000115 "An anomaly of the retina with serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE), and associated with blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the centre of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months." ; dc:date "2017-12-14T13:33:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The condition can be precipitated by psychosocial stress and hypercortisolism. Ophthalmoscopic signs of CSC range from mono- or paucifocal RPE lesions with prominent elevation of the neurosensory retina by clear fluid - typical of cases of recent onset - to shallow detachments overlying large patches of irregularly depigmented RPE. The spectrum of lesions includes RPE detachments. Granular or fibrinous material may accumulate in the subretinal cavity. Serous detachment often resolves spontaneously." ; rdfs:label "Central serous chorioretinopathy"@en ; rdfs:subClassOf obo:HP_0000532 . obo:HP_0025568 dc:date "2017-12-14T13:37:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of the choroidal vasculature"@en ; rdfs:subClassOf obo:HP_0000610 . obo:HP_0025569 obo:IAO_0000115 "The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization." ; dc:date "2017-12-14T13:39:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The presence of choroidal polyps and BVN can lead to recurrent episodes of exudative retinal detachment, serous or hemorrhagic pigment epithelial detachment (PED), subretinal hemorrhage, and subretinal exudation." ; rdfs:label "Polypoidal choroidal vasculopathy"@en ; rdfs:subClassOf obo:HP_0025568 . obo:HP_0025570 obo:IAO_0000115 "Increased tendency of choiroidal blood vessels to allow fluids to leak characterized by multifocal choroidal hyperfluorescence on indocyanine green angiography (ICGA)." ; dc:date "2017-12-14T13:49:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Choroidal hyperpermeability" ; a owl:Class ; rdfs:label "Choroidal vascular hyperpermeability"@en ; rdfs:subClassOf obo:HP_0025568 . obo:HP_0025571 obo:IAO_0000115 "A type of cataract that shows a spectacular display of multiple colours that glitters with the change of incident light like an illuminated Christmas tree." ; dc:date "2017-12-14T13:58:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Christmas tree cataract"@en ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0025572 obo:IAO_0000115 "Punctal stenosis is a condition in which the external opening of the lacrimal canaliculus is narrowed or occluded." ; dc:date "2017-12-14T14:21:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lacrimal punctum stenosis", "Stenosis of the lacrimal punctum" ; a owl:Class ; rdfs:comment "Epiphora is a common complaint encountered by ophthalmologists, with a broad differential diagnosis. One of the least discussed etiologies of epiphora is stenosis of the external lacrimal punctum. When it occurs, the most common presenting symptom is tearing, but patients may have vague complaints of ocular discomfort." ; rdfs:label "Punctal stenosis"@en ; rdfs:subClassOf obo:HP_0011479 . obo:HP_0025573 obo:IAO_0000115 "A mild form of myopia with up to -3.00 diopters." ; dc:date "2017-12-14T14:38:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mild myopia"@en ; rdfs:subClassOf obo:HP_0000545 . obo:HP_0025574 obo:IAO_0000115 "Bleeding occurring within the macula lutea of the retina." ; dc:date "2017-12-15T14:47:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Macular haemorrhage" ; a owl:Class ; rdfs:label "Macular hemorrhage"@en ; rdfs:subClassOf obo:HP_0000573, obo:HP_0001103 . obo:HP_0025575 obo:IAO_0000115 "Any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart." ; dc:date "2017-12-15T23:00:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2820" ; a owl:Class ; rdfs:label "Abnormal superior vena cava morphology"@en ; rdfs:subClassOf obo:HP_0005345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025576 obo:IAO_0000115 "Any structural anomaly of the principal vein draining blood from the lower portion of the body." ; dc:date "2017-12-15T23:02:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2810" ; a owl:Class ; rdfs:label "Abnormal inferior vena cava morphology"@en ; rdfs:subClassOf obo:HP_0005345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001072 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025578 obo:IAO_0000115 "Aortic valve prolapse can be diagnosed when either or both of the right or non-coronary aortic valve cusps (seen in the cross sectional echocardiographic long axis view) show backward bowing towards the left ventricle beyond a line joining the points of attachment of the aortic valve leaflets to the annulus." ; dc:date "2017-12-15T23:47:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1452" ; a owl:Class ; rdfs:label "Aortic valve prolapse"@en ; rdfs:subClassOf obo:HP_0001646 . obo:HP_0025579 obo:IAO_0000115 "Any structural abnormality of the left atrium." ; dc:date "2017-12-15T23:54:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:3010" ; a owl:Class ; rdfs:label "Abnormal left atrium morphology"@en ; rdfs:subClassOf obo:HP_0005120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025580 obo:IAO_0000115 "Any structural abnormality of the right atrium." ; dc:date "2017-12-15T23:56:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1770" ; a owl:Class ; rdfs:label "Abnormal right atrium morphology"@en ; rdfs:subClassOf obo:HP_0005120 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025581 obo:IAO_0000115 "Bleeding occurring within the fovea." ; dc:date "2018-01-13T19:21:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Foveal haemorrhage" ; a owl:Class ; rdfs:label "Foveal hemorrhage"@en ; rdfs:subClassOf obo:HP_0025574 . obo:HP_0025582 obo:IAO_0000115 "Bleeding between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation." ; dc:date "2018-01-13T19:25:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sub-macular haemorrhage", "Sub-macular hemorrhage", "Submacular haemorrhage" ; a owl:Class ; rdfs:label "Submacular hemorrhage"@en ; rdfs:subClassOf obo:HP_0025243, obo:HP_0025574 . obo:HP_0025583 obo:IAO_0000115 "Golden, scintillating, particulate reflection noted on fundus examination (typically in the macula and sparing the fovea). The term tapetal is used to describe this 'metallic' sheen appearance as it is thought to be similar to the 'tapetal' reflex seen in the eyes of certain animals." ; dc:date "2018-01-13T19:32:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This appearance is typically seen in female carriers of X-linked RP associated mutations." ; rdfs:label "Tapetal-like fundal reflex"@en ; rdfs:subClassOf obo:HP_0001098 . obo:HP_0025584 obo:IAO_0000115 "A form of manifest strabismus (heterotropia) in which one eye is deviated downwards when both eyes are open." ; dc:date "2018-01-13T19:39:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypotropia"@en ; rdfs:subClassOf obo:HP_0025588, obo:HP_0032012 . obo:HP_0025585 obo:IAO_0000115 "Tendency for the visual axis of one eye to be higher than that of the other." ; dc:date "2018-01-13T19:42:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperphoria"@en ; rdfs:subClassOf obo:HP_0025587, obo:HP_0032011 . obo:HP_0025586 obo:IAO_0000115 "A type of strabismus characterized by permanent upward deviation of the visual axis of one eye." ; dc:date "2018-01-13T19:44:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypertropia"@en ; rdfs:subClassOf obo:HP_0025587, obo:HP_0032012 . obo:HP_0025587 obo:IAO_0000115 "A type of strabismus in which the visual axis of one eye is higher than that of the other." ; dc:date "2018-01-13T19:45:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyperphoria is a latent deviation where the eyes remain aligned under normal binocular vision. Hypertropia is a manifest deviation in which the eyes are not aligned under binocular conditions." ; rdfs:label "Hyperdeviation"@en ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0025588 obo:IAO_0000115 "A type of strabismus in which the visual axis of one eye is lower than that of the other." ; dc:date "2018-01-13T19:50:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hypophoria is a latent deviation where the eyes remain aligned under normal binocular vision. Hypotropia is a manifest deviation in which the eyes are not aligned under binocular conditions." ; rdfs:label "Hypodeviation"@en ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0025589 obo:IAO_0000115 "Cyclodeviation is defined as the rotation of an eyeball along the anteroposterior axis and cyclotropia as a misalignment of cyclodeviation between the two eyes." ; dc:date "2018-01-13T19:57:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Patients with torsional deviations rarely complain of torsional diplopia and thus, cyclotropia has largely not been of significant clinical concern." ; rdfs:label "Cyclodeviation"@en ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0025590 obo:IAO_0000115 "A functional anomaly of the muscles of the eye." ; dc:date "2018-01-13T20:11:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal extraocular muscle physiology"@en ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0025591 obo:IAO_0000115 "A functional anomaly of the superior oblique muscle, a fusiform muscle that originates in the upper, medial side of the orbit. The superior oblique muscle abducts, depresses and internally rotates the eye, and is the only extraocular muscle innervated by the fourth cranial nerve." ; dc:date "2018-01-13T20:12:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A neurological examination includes assessment of the trochlear nerve (CN IV) which innervates the superior oblique muscle. The test for CN IV function is for the patient to depress and adduct the eye (ie. to look down and in). This movement is impaired in the presence of a trochlear nerve palsy." ; rdfs:label "Abnormal superior oblique muscle physiology"@en ; rdfs:subClassOf obo:HP_0031739 . obo:HP_0025592 obo:IAO_0000115 "Decreased strength of the superior oblique muscle." ; dc:date "2018-01-13T20:17:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Superior oblique palsy" ; a owl:Class ; rdfs:label "Superior oblique muscle weakness"@en ; rdfs:subClassOf obo:HP_0025591 . obo:HP_0025593 obo:IAO_0000115 "Mechanical limitation of the range of movement of the superior oblique muscle." ; dc:date "2018-01-13T20:38:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to deficits produced by primary muscle weakness, restriction means that the affected extraocular muscle cannot move passively any more than actively." ; rdfs:label "Superior oblique muscle restriction"@en ; rdfs:subClassOf obo:HP_0025592 . obo:HP_0025594 obo:IAO_0000115 "An ocular motility abnormality characterized by an overacting superior oblique muscle resulting to vertical incomitance of the eyes in lateral gaze. On examination, this is commonly seen as a downshoot of the adducting eye occuring when gaze is directed into the field of action of the inferior oblique muscle, producing a greater downward excursion of the adducted eye than of the abducted eye." ; dc:date "2018-01-13T20:41:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior oblique muscle overaction"@en ; rdfs:subClassOf obo:HP_0025591 . obo:HP_0025595 obo:IAO_0000115 "Reduced ocular movement of the superior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-13T20:46:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Under-depression in adduction" ; a owl:Class ; rdfs:label "Superior oblique muscle underaction"@en ; rdfs:subClassOf obo:HP_0025592 . obo:HP_0025596 obo:IAO_0000115 "A functional anomaly of the inferior oblique muscle, an extraocular muscle that has its origin on the maxillary bone just posterior to the inferior medial orbital rim and lateral to the nasolacrimal canal and that is innervated by the inferior branch of the oculomotor nerve." ; dc:date "2018-01-13T20:54:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The major functions of the inferior oblique muscle are extorsion (external rotation), elevation, and abduction." ; rdfs:label "Abnormal inferior oblique muscle physiology"@en ; rdfs:subClassOf obo:HP_0031739 . obo:HP_0025597 obo:IAO_0000115 "Mechanical limitation of the range of movement of the inferior oblique muscle." ; dc:date "2018-01-13T21:15:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to deficits produces by primary muscle weakness, extraocular muscle restriction cannot move passively any more than actively." ; rdfs:label "Inferior oblique muscle restriction"@en ; rdfs:subClassOf obo:HP_0025598 . obo:HP_0025598 obo:IAO_0000115 "Decreased strength of the inferior oblique muscle." ; dc:date "2018-01-13T21:23:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inferior oblique palsy" ; a owl:Class ; rdfs:label "Inferior oblique muscle weakness"@en ; rdfs:subClassOf obo:HP_0025596 . obo:HP_0025599 obo:IAO_0000115 "A common ocular motility disorder characterized by vertical incomitance of the eyes in lateral gaze. In primary inferior oblique muscle overaction, an upshoot of the adducting eye occurs when gaze is directed into the field of action of the inferior oblique muscle, producing a greater upward excursion of the adducted eye than of the abducted eye." ; dc:date "2018-01-13T21:25:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior oblique muscle overaction"@en ; rdfs:subClassOf obo:HP_0025596 . obo:HP_0025600 obo:IAO_0000115 "A functional anomaly of the inferior rectus muscle, which is innervated by the inferior division of oculomotor nerve and functions in the depression, adduction, and lateral rotation (extortion) of the eye." ; dc:date "2018-01-13T21:31:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal inferior rectus muscle physiology"@en ; rdfs:subClassOf obo:HP_0031748 . obo:HP_0025601 obo:IAO_0000115 "Decreased strength of the inferior rectus muscle." ; dc:date "2018-01-13T22:23:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior rectus muscle weakness"@en ; rdfs:subClassOf obo:HP_0025600 . obo:HP_0025602 obo:IAO_0000115 "Mechanical limitation of the range of movement of the inferior rectus muscle." ; dc:date "2018-01-13T22:24:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to deficits produced by primary muscle weakness, restriction means that the affected extraocular muscle cannot move passively any more than actively." ; rdfs:label "Inferior rectus muscle restriction"@en ; rdfs:subClassOf obo:HP_0025601 . obo:HP_0025603 obo:IAO_0000115 "A functional anomaly of the superior rectus muscle, an extraocular muscle that is innervated by the superior division of the oculomotor nerve, and whose primary function is the elevation of the globe." ; dc:date "2018-01-13T22:28:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal superior rectus muscle physiology"@en ; rdfs:subClassOf obo:HP_0031748 . obo:HP_0025604 obo:IAO_0000115 "A schwannoma (benign, usually encapsulated slow growing tumor composed of Schwann cells) located in the orbit." ; dc:date "2018-01-13T22:31:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orbital schwannoma"@en ; rdfs:subClassOf obo:HP_0100012 . obo:HP_0025605 obo:IAO_0000115 "Delayed descent of the upper eyelid on downgaze. Also described by some authors as von Graefe sign." ; dc:date "2018-01-13T22:37:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eyelid lag", "Lid lag" ; oboInOwl:hasRelatedSynonym "von Graefe sign" ; a owl:Class ; rdfs:label "Lid lag on downgaze"@en ; rdfs:subClassOf obo:HP_0031785 . obo:HP_0025606 obo:IAO_0000115 "A functional anomaly of the medial rectus muscle, an extraocular muscle that is innervated by the inferior division of the oculomotor nerve and whose sole action is the adduction of the eyeball." ; dc:date "2018-01-13T22:41:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal medial rectus muscle physiology"@en ; rdfs:subClassOf obo:HP_0031740 . obo:HP_0025607 obo:IAO_0000115 "An inward turning (inversion) of the margin of the upper eyelid." ; dc:date "2018-01-13T22:44:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Upper eyelid entropion"@en ; rdfs:subClassOf obo:HP_0000621 . obo:HP_0025608 obo:IAO_0000115 "An outward turning (eversion) or rotation of the eyelid margin (i.e., ectropion) caused by shortening or contraction of the anterior or middle lamellae related to scarring." ; dc:date "2018-01-13T22:49:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cicatricial ectropion may occur owing to burns, lacerations, or infection of the skin of the eyelid." ; rdfs:label "Cicatricial ectropion"@en ; rdfs:subClassOf obo:HP_0000656 . obo:HP_0025609 obo:IAO_0000115 "A type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles." ; dc:date "2018-01-13T22:52:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior blepharitis"@en ; rdfs:subClassOf obo:HP_0000498 . obo:HP_0025610 obo:IAO_0000115 "A type of blepharitis that affects the meibomian glands and meibomian gland orifices. This abnormality can be associated with a spectrum of appearances ranging from meibomian seborrhoea (foaming meibomian gland secretions) and meibomianitis (inflamed meibomian glands), to chalazia." ; dc:date "2018-01-13T22:53:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Meibomian gland dysfunction" ; oboInOwl:hasRelatedSynonym "Meibomian gland disease" ; a owl:Class ; rdfs:label "Posterior blepharitis"@en ; rdfs:subClassOf obo:HP_0000498 . obo:HP_0025611 obo:IAO_0000115 "A type of epicanthus in which more extensive epicanthal folds with their origins in the eyebrow cover, pass in front of and lateral to the medial canthus (middle corner of the eye)." ; dc:date "2018-01-13T22:58:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Epicanthus superciliaris"@en ; rdfs:subClassOf obo:HP_0000286 . obo:HP_0025612 obo:IAO_0000115 "A type of refractive error related abnormal curvatures on the anterior or posterior surface of the cornea." ; dc:date "2018-01-13T23:06:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Corneal astigmatism"@en ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0025613 obo:IAO_0000115 "Seizures presenting with an emotion or the appearance of having an emotion as an early prominent feature, such as fear, spontaneous joy or euphoria, laughing (gelastic), or crying, (dacrystic). These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer." ; dc:date "2018-10-07T16:18:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Affective seizure", "Emotional seizure", "Focal affective seizure", "Partial emotional seizure" ; a owl:Class ; rdfs:comment "Focal emotional seizures are characterized by alterations in mood or emotion, or the appearance of altered emotion without the subjective emotion, at seizure onset. These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer. Emotions include: fear/anxiety/panic, laughing (gelastic), crying (dacrystic), pleasure, anger." ; rdfs:label "Focal emotional seizure"@en ; rdfs:subClassOf obo:HP_0032679 . obo:HP_0025615 dc:date "2019-04-08T22:41:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abscess"@en ; rdfs:subClassOf obo:HP_0032251 . obo:HP_0025616 obo:IAO_0000115 "An abscess not caused by infection with pyogenic bacteria. Operationally, a sterile abscess is inferred if investigations of an abscess fail to reveal evidence of pathogenic organisms." ; dc:date "2019-04-08T22:44:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sterile abscess"@en ; rdfs:subClassOf obo:HP_0025615 . obo:HP_0025617 obo:IAO_0000115 "An abnormal number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies." ; dc:date "2019-04-08T23:51:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal plasma cell count"@en ; rdfs:subClassOf obo:HP_0002846 . obo:HP_0025618 obo:IAO_0000115 "An abnormally low number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies." ; dc:date "2019-04-08T23:52:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced plasma cell count"@en ; rdfs:subClassOf obo:HP_0025617 . obo:HP_0025619 obo:IAO_0000115 "An abnormally high number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies." ; dc:date "2019-04-08T23:53:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated plasma cell count"@en ; rdfs:subClassOf obo:HP_0025617 . obo:HP_0025620 obo:IAO_0000115 "An abnormal proportion of central memory CD4+ T cells. These are memory cells that are located in the secondary lymphoid organs. These cells may have a CD3/CD4/CD62L+/CD45RA- phenotype." ; dc:date "2019-04-08T23:55:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of central memory CD4+, alpha-beta T cells" ; a owl:Class ; rdfs:label "Abnormal proportion of CD4+ central memory cells"@en ; rdfs:subClassOf obo:HP_0025540, obo:HP_0410379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000904 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025621 obo:IAO_0100001 "HP:0410393" ; a owl:Class ; rdfs:comment "This was a duplicate, hence it was obsoleted. https://github.com/obophenotype/human-phenotype-ontology/issues/5695" ; rdfs:label "obsolete Increased proportion of CD4+ central memory cells"@en ; owl:deprecated true . obo:HP_0025622 obo:IAO_0100001 "HP:0410388" ; a owl:Class ; rdfs:comment "Term was a duplicate, hence it was obsoleted. https://github.com/obophenotype/human-phenotype-ontology/issues/5695" ; rdfs:label "obsolete Decreased proportion of CD4+ central memory cells"@en ; owl:deprecated true . obo:HP_0025623 obo:IAO_0000115 "An abnormal proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dc:date "2019-04-09T00:11:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0410382" ; oboInOwl:hasExactSynonym "Abnormal proportion of CD4-positive effector memory cells", "Abnormal proportion of effector memory CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Abnormal proportion of CD4+ effector memory cells"@en ; rdfs:subClassOf obo:HP_0025540, obo:HP_0031392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025624 obo:IAO_0000115 "An abnormally decreased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dc:date "2019-04-09T00:13:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0410387" ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+ effector memory T cells", "Decreased proportion of CD4-positive effector memory T cells", "Decreased proportion of effector memory CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Reduced proportion of CD4+ effector memory T cells"@en ; rdfs:subClassOf obo:HP_0025623, obo:HP_0032218 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025625 obo:IAO_0000115 "An abnormally increased proportion of effector memory CD4+ T cells. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype." ; dc:date "2019-04-09T00:13:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased proportion of CD4+ effector memory T cells", "Increased proportion of CD4-positive effector memory T cells", "Increased proportion of effector CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Elevated proportion of CD4+ effector memory T cells"@en ; rdfs:subClassOf obo:HP_0025623, obo:HP_0032219 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025626 obo:IAO_0000115 "An abnormally high concentration of oleic acid (oleate) in the blood circulation." ; dc:date "2019-04-09T00:25:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating oleate level"@en ; rdfs:subClassOf obo:HP_0003455 . obo:HP_0025627 obo:IAO_0000115 "An abnormally high concentration of octadecanoate in the blood circulation. Octadecanoate is a fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid)." ; dc:date "2019-04-09T00:28:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating octadecanoate level"@en ; rdfs:subClassOf obo:HP_0003455 . obo:HP_0025628 obo:IAO_0000115 "An abnormally high concentration of myristoleate in the blood circulation." ; dc:date "2019-04-09T00:31:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating myristoleate level"@en ; rdfs:subClassOf obo:HP_0003455 . obo:HP_0025629 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against myelin-associated glycoprotein (MAG)." ; dc:date "2019-04-09T00:48:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The anti-myelin-associated glycoprotein (MAG) neuropathy is an antibody-mediated demyelinating neuropathy. The clinical picture is characterized by a distal and symmetric, mostly sensory neuropathy. Monoclonal immunoglobulin M anti-MAG antibodies are uniquely found in this condition and are believed to be pathogenic." ; rdfs:label "Anti-myelin-associated glycoprotein antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0025630 obo:IAO_0000115 "Increased amount of argininosuccinate in the urine." ; dc:date "2019-04-09T00:55:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Argininosuccinate lyase (ASL) belongs to the hepatic urea cycle detoxifying ammonia, and the citrulline-nitric oxide (NO) cycle producing NO. ASL-deficient patients present argininosuccinic aciduria characterised by hyperammonaemia, multiorgan disease and neurocognitive impairment." ; rdfs:label "Argininosuccinic aciduria"@en ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0025631 obo:IAO_0000115 "Increased amount of alpha-aminobutyric acid in the urine." ; dc:date "2019-04-09T01:21:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alpha-aminobutyric aciduria"@en ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0025632 obo:IAO_0000115 "An abnormal reduction in the amount of reactive oxygen produced by neutrophils in the respiratory burst." ; dc:date "2019-04-09T01:36:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Polymorphonuclear neutrophils comprise more than 60% ofthe circulating white blood cells in humans. They have a central role in innate immunity and they regulate adaptive immunity. In healthy individuals, circulating neutrophils are freely flowing in a resting, dormant state. Upon infection, neutrophils are the first circulating cells to arrive at the infection and inflammatory site. Phagocytosis triggers the activation program of the neutrophils, leading to the intraphagosomal release of antibacterial peptides, proteases, myeloperoxidase, and superoxide anion (O2-), which is produced via the activation of the NADPH oxidase. Superoxide anion is the initiating spark leading to the generation of reactive oxygen species (ROS), i.e., hydrogen peroxide (H2O2), hydroxylradical and hypochlorous acid (HOCl), all contributing to the death and destruction of the bacteria within the phagosome. ROS production by the phagocytes was first referred as the respiratory burst or oxidative burst due to the rapid and cyanide-insensitive increase in oxygen uptake, increase in glucose consumption, andimmediate ROS release. The enzyme system dedicated to superoxide anion production, i.e., the phagocyte NADPH oxidase, a member of the NOX family of proteins also referred as NOX2, is composed of six proteins, two trans-membrane proteins (p22phox and gp91phox) that form theflavocytochrome b558, and four soluble proteins (p47phox,p67phox, and p40phox and the small G-proteins, Rac1/2)." ; rdfs:label "Reduced reactive oxygen species production in neutrophils"@en ; rdfs:subClassOf obo:HP_0025463 . obo:HP_0025633 obo:IAO_0000115 "A structural abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder." ; dc:date "2019-04-26T17:40:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ureter morphology"@en ; rdfs:subClassOf obo:HP_0000069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025634 obo:IAO_0000115 "A functional abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder." ; dc:date "2019-04-26T17:43:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ureter physiology"@en ; rdfs:subClassOf obo:HP_0000069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0025635 obo:IAO_0000115 "A growth protruding from the mucous membrane of the ureter. Ureteral polyps can be attached to the ureter by a broad base or a thin stalk." ; dc:date "2019-04-26T17:44:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C4530" ; oboInOwl:hasExactSynonym "Polyp of the ureter", "Ureter polyp" ; a owl:Class ; rdfs:label "Ureteral polyp"@en ; rdfs:subClassOf obo:HP_0100516 . obo:HP_0025636 obo:IAO_0000115 "Inflammation of the inner lining of the uterus (endometrium)." ; dc:date "2019-04-26T17:48:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endometrial inflammation", "Inflammation of the inner lining of the uterus" ; a owl:Class ; rdfs:label "Endometritis"@en ; rdfs:subClassOf obo:HP_0030126 . obo:HP_0025637 obo:IAO_0000115 "Narrowing of an artery due to constriction of the blood vessels." ; dc:date "2019-04-26T17:51:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Angiospasm", "Blood vessel spasm", "Vascular spasm" ; a owl:Class ; rdfs:label "Vasospasm"@en ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0025638 obo:IAO_0000115 "An increased level of N-butyrylglycine in the urine." ; dc:date "2019-04-26T18:06:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Butyrylglycine is a N-acylglycine obtained by formal condensation of the carboxy group of butyric acid with the amino group of glycine. Its urinary excretion is increased in certain inborn errors of metabolism." ; rdfs:label "Elevated urinary N-butyrylglycine"@en ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0025639 obo:IAO_0000115 "An abnormally elevated amount of zinc in the urine, typically as assessed by a 24 hour urine collection." ; dc:date "2019-04-26T18:12:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary zinc level"@en ; rdfs:subClassOf obo:HP_0025640 . obo:HP_0025640 obo:IAO_0000115 "An abnormal concentration or amount of a mineral in the urine. Medically relevant minerals include calcium, phosphorus, potassium, sodium, chloride, magnesium, iron, zinc, iodine, chromium, copper, fluoride, molybdenum, manganese, and selenium." ; dc:date "2019-04-26T18:13:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary mineral level"@en ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0025641 obo:IAO_0000115 "The concentration of glycolate in the blood circulation is above the upper limit of normal." ; dc:date "2019-04-26T18:31:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Glycolate is a hydroxy monocarboxylic acid anion that is acetate in which the methyl group has been hydroxylated." ; rdfs:label "Elevated circulating glycolate concentration"@en ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0025643 obo:IAO_0000115 "A cerebrospinal fluid-filled nerve root cyst most often localized in the sacral spine." ; dc:date "2019-07-24T09:26:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Perineural cyst" ; a owl:Class ; rdfs:label "Tarlov cyst"@en ; rdfs:subClassOf obo:HP_0030724 . obo:HP_0025644 obo:IAO_0000115 "Fixation off sensitivity (FOS) is characterized by posterior or generalized epileptiform discharges that consistently occur with conditions that eliminate central vision, such as closed eyes, complete darkness, modified Ganzfeld stimulation (using a large white surface without visual cues), and Frenzel lenses. The FOS electroencephalogram (EEG) pattern usually consists of spikes/polyspikes and waves localized in occipital regions (bilateral or unilateral) or generalized discharges. It is usually inhibited by fixation of gaze, observing patterns, or intermittent photic stimulation (e.g., flashing light or patterns used as stimuli during the recording of the EEG)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fixation-off sensitivity" ; a owl:Class ; rdfs:comment "FOS occurs mainly in children who have non-acquired focal epilepsies with occipital epileptiform discharges and in people with generalized epilepsies with photosensitivity such as eyelid myoclonia with absences. It has been observed in people with epilepsies due to structural brain lesions and people without epilepsy who have posterior epileptiform discharges." ; rdfs:label "Fixation-off epileptiform discharges"@en ; rdfs:subClassOf obo:HP_0011182 . obo:HP_0025646 obo:IAO_0000115 "Polymicrogyria that affects all or some of both cerebral hemispheres." ; dcterms:creator ; a owl:Class ; rdfs:comment "Bilateral polymicrogyria is not always generalized or perisylvian." ; rdfs:label "Bilateral polymicrogyria"@en ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0025647 obo:IAO_0000115 "A type of nephrotic syndrome in which complete remission (albumin urine dipstick negative/trace or proteinuria <4mg/m2/d or urinary protein to creatinine ratio <200mg/g (<20 mg/mmol) for 3 consecutive days) is achieved within initial 4 weeks of corticosteroid therapy." ; dcterms:creator ; oboInOwl:hasExactSynonym "SSNS" ; a owl:Class ; rdfs:label "Steroid-sensitive nephrotic syndrome"@en ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0025648 obo:IAO_0000115 "A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of one relapse (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response, or one to three relapses in any 12-month period." ; dcterms:creator ; a owl:Class ; rdfs:comment "No biopsy needed. Relapses are treated with steroids according to local protocols." ; rdfs:label "Steroid-sensitive nephrotic syndrome with infrequent relapses"@en ; rdfs:subClassOf obo:HP_0025647 . obo:HP_0025649 obo:IAO_0000115 "A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of two or more relapses (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response or four or more relapses in any 12-month period." ; dcterms:creator ; a owl:Class ; rdfs:comment "Biopsy is necessary to determine underlying histology. Treatment with levamisole or immunosuppression (e.g. calcineurin inhibitors, cyclophosphamide or mycophenolat mofetil) in order to reduce steroid toxicity." ; rdfs:label "Steroid-sensitive nephrotic syndrome with frequent relapses"@en ; rdfs:subClassOf obo:HP_0025647 . obo:HP_0025650 obo:IAO_0000115 "A type of nephrotic syndrome in which two consecutive relapses (albumin urine dipstick at least 3+ or proteinuria greater than 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) occur during corticosteroid therapy, or within 14 days of ceasing therapy." ; dcterms:creator ; oboInOwl:hasExactSynonym "SDNS" ; a owl:Class ; rdfs:comment "Biopsy is necessary to determine underlying histology. Treatment with levamisole or immunosuppression (e.g. calcineurin inhibitors, cyclophosphamide or mycophenolat mofetil) in order to reduce steroid toxicity." ; rdfs:label "Steroid-dependent nephrotic syndrome"@en ; rdfs:subClassOf obo:HP_0000100 . obo:HP_0025652 obo:IAO_0000115 "Abnormal placental adhesion is characterized by an anomalous adherence of the placenta to the uterine wall. Based on the degree of adhesion, placental invasion can be classified into accreta, increta, or percreta." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal placental adhesion into the uterine wall"@en ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0025653 obo:IAO_0000115 "Placenta percreta is a rare form of morbidly adherent placenta with penetration through the myometrium reaching serosa and even adjacent pelvic organs." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal placental pentration beyond the uterine wall" ; a owl:Class ; rdfs:label "Placenta percreta"@en ; rdfs:subClassOf obo:HP_0025652 . obo:HP_0025654 obo:IAO_0000115 "Abnormally firm adherence of the placenta to the uterine wall." ; dcterms:creator ; a owl:Class ; rdfs:label "Placenta accreta"@en ; rdfs:subClassOf obo:HP_0025652 . obo:HP_0025655 obo:IAO_0000115 "Abnormal placental pentration into but not beyond the uterine wall." ; dcterms:creator ; a owl:Class ; rdfs:label "Placenta increta"@en ; rdfs:subClassOf obo:HP_0025652 . obo:HP_0025656 obo:IAO_0000115 "Sonographic detection of a double bubble sign in the upper abdomen is strongly indicative of duodenal obstruction. One bubble represents fetal stomach, and the other is attributed to a dilated proximal part of the duodenum; continuity between both bubbles is required for the sign." ; dcterms:creator ; a owl:Class ; rdfs:label "Prenatal double bubble sign"@en ; rdfs:subClassOf obo:HP_0034207 . obo:HP_0025657 dcterms:creator ; a owl:Class ; rdfs:label "Abnormal umbilical blood flow measurement"@en ; rdfs:subClassOf obo:HP_0010881, obo:HP_0034059 . obo:HP_0025658 obo:IAO_0100001 "HP:0025715" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal umbilical artery Doppler pattern in pregnancy"@en ; owl:deprecated true . obo:HP_0025659 obo:IAO_0000115 "A reduction in the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating creatine kinase concentration"@en ; rdfs:subClassOf obo:HP_0040081 . obo:HP_0025660 obo:IAO_0000115 "A type of Chiari malformation that consists of brainstem herniation and a towering cerebellum in addition to the herniated cerebellar tonsils and vermis due to an open distal spinal dysraphism/myelomeningocele." ; dcterms:creator ; oboInOwl:hasExactSynonym "Arnold-Chiari type II malformation" ; a owl:Class ; rdfs:comment "While Chiari I malformation is thought to result from a small posterior fossa, Chiari II occurs due to in utero malformation of the spine and cranial structures. The underlying cause of Chiari II malformation is thought to be an in utero CSF leak due to open spinal dysraphism, resulting in a small posterior fossa with distortion of the cerebellum and a diminutive cisterna magna, sometimes accompanied by ventriculomegaly and an altered shape of the calvarium. Chiari II malformation is always associated with spinal myelomeningocele or myelocele. Classical signs described on prenatal ultrasound include lemon sign and banana cerebellum sign." ; rdfs:label "Chiari type II malformation"@en ; rdfs:subClassOf obo:HP_0002308 . obo:HP_0025661 obo:IAO_0000115 "A type of Chiari malformation that involves herniation of the hindbrain (cerebellum with or without the brainstem) into a low occipital or high cervical meningoencephalocele." ; dcterms:creator ; oboInOwl:hasExactSynonym "Arnold-Chiari type III malformation" ; a owl:Class ; rdfs:label "Chiari type III malformation"@en ; rdfs:subClassOf obo:HP_0002308 . obo:HP_0025662 obo:IAO_0000115 "An anomalous structural finding of the fetal skeleton. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other terms from the skeletal hierarchy can also be used to describe fetal phenotypes." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal skeletal morphology"@en ; rdfs:subClassOf obo:HP_0011842, obo:HP_0034058 . obo:HP_0025663 obo:IAO_0000115 "This ratio relates the length of the fetal femur to that of the fetal foot. The ratio is approximately 1 throughout the age range of 14 to 40 weeks of gestation. A substantial reduction in the raio can help differentiate fetuses that have dysplastic limb reduction from those whose limbs are short because of constitutional factors or IUGR. It can reduce the problem of an unknown gestational age and help to distinguish between fetal skeletal dysplasia and intrauterine growth retardation caused by other factors." ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fetal femur/foot length ratio"@en ; rdfs:subClassOf obo:HP_0025662 . obo:HP_0025664 obo:IAO_0000115 "Birth at 32 to 36 completed weeks of gestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "World Health Organization definition." ; rdfs:label "Moderate to late preterm birth"@en ; rdfs:subClassOf obo:HP_0001622 . obo:HP_0025665 obo:IAO_0000115 "Birth before 28 completed weeks of gestation (up to and including 27 weeks and 6 days of gestation)." ; dcterms:creator ; a owl:Class ; rdfs:label "Extremely preterm birth"@en ; rdfs:subClassOf obo:HP_0001622 . obo:HP_0025666 obo:IAO_0000115 "Birth before 32 completed weeks of gestation (28 up to but not including 32 weeks)." ; dcterms:creator ; a owl:Class ; rdfs:label "Very preterm birth"@en ; rdfs:subClassOf obo:HP_0001622 . obo:HP_0025667 obo:IAO_0000115 "A structural anomaly in the fetal neck region. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal neck anomaly"@en ; rdfs:subClassOf obo:HP_0025668, obo:HP_0034058 . obo:HP_0025668 obo:IAO_0000115 "Any structural anomaly of the neck region." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal neck morphology"@en ; rdfs:subClassOf obo:HP_0000464 . obo:HP_0025669 obo:IAO_0000115 "Any functional anomaly of the neck region." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal neck physiology"@en ; rdfs:subClassOf obo:HP_0000464 . obo:HP_0025670 obo:IAO_0000115 "Syntelencephaly is a rare malformation that consists of an abnormal midline connection of the cerebral hemispheres in the posterior frontal and parietal regions, with interhemispheric separation of the basal forebrain, anterior frontal lobes, and occipital regions." ; dcterms:creator ; a owl:Class ; rdfs:comment "This condition differs from holoprosencephaly (HPE) in that the midline fusion in syntelencephaly is complete but segmental, while the structural brain anomalies seen in the HPE spectrum progress smoothly in severity in a posterior to anterior fusion." ; rdfs:label "Syntelencephaly"@en ; rdfs:subClassOf obo:HP_0001360 . obo:HP_0025671 obo:IAO_0000115 "An abnormal accumulation of fluid in which the heart is partially or completely surrounded by fluid that is seen in all views and the thickness of the fluid as observed by prenatal ultrasound is above age-dependent norms." ; dcterms:creator ; a owl:Class ; rdfs:comment "Fetal pericardial effusion appears in conditions such as hydrops fetalis, heart structural or rhythm alterations, however, it can also be observed in isolation." ; rdfs:label "Fetal pericardial effusion"@en ; rdfs:subClassOf obo:HP_0010948 . obo:HP_0025672 obo:IAO_0000115 "A separation of skin in one or more regions of the body or even along the entire length of body wall (to a degree greater than gestational-age related norms) related to pathologically increased fluid accumulation in the subcutaneous tissue." ; dcterms:creator ; a owl:Class ; rdfs:comment "In first trimester ultrasound examination generalized skin edema is often the first feature of hydrops fetalis." ; rdfs:label "Fetal skin edema"@en ; rdfs:subClassOf obo:HP_0025723 . obo:HP_0025673 obo:IAO_0000115 "A type of ascites (peritoneal fluid collection) that is divided into loculi (compartments) by septa (fibrous walls). Ascites fluid can become loculated when confined by adhesions, malignancy or infection." ; dcterms:creator ; oboInOwl:hasExactSynonym "Septated ascites" ; a owl:Class ; rdfs:label "Loculated ascites"@en ; rdfs:subClassOf obo:HP_0001541 . obo:HP_0025674 obo:IAO_0000115 "A meconium-containing cyst in the peritoneal space . Meconium pseudocysts form in the presence of meconium peritonitis, which is defined as a sterile peritonitis caused by escape of meconium from the intestinal tract into the general peritoneal cavity during the fetal or perinatal period. When the extruded meconium becomes walled off, it can form a rim-calcified mass representing the meconium pseudocyst." ; dcterms:creator ; a owl:Class ; rdfs:comment "A fetal intraperitoneal cystic mass that shows high T1 and low T2 signals in prenatal magnetic resonance imaging is considered pathognomonic of meconium pseudocyst. See Figure 1 of PMID: 19293041." ; rdfs:label "Meconium pseudocyst"@en ; rdfs:subClassOf obo:HP_0034207 . obo:HP_0025675 obo:IAO_0000115 "A prenatal partial or complete closure of the ductus arteriosus (i.e., prior to delivery)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fetal PAD narrowing-closure", "Fetal PDA narrowing-closure", "Fetal arterial duct narrowing-closure", "Fetal ductus arteriosus narrowing-closure", "Foetal PAD narrowing-closure", "Foetal PDA narrowing-closure", "Foetal arterial duct narrowing-closure", "Foetal ductus arteriosus narrowing-closure", "Idiopathic constriction of the fetal ductus arteriosus", "Idiopathic constriction of the foetal ductus arteriosus", "PCDA" ; a owl:Class ; rdfs:label "Premature closure of the ductus arteriosus"@en ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0025676 obo:IAO_0000115 "Fetal pleural effusion is the accumulation of excess fluid in the layers of tissue (pleura) lining the lungs and wall of the chest. It may be primary, also termed hydrothorax, occurring as an isolated finding or it may be secondary, most commonly resulting from non-immune hydrops." ; dcterms:creator ; a owl:Class ; rdfs:comment "With the ongoing evolution and more widespread use of obstetric ultrasound, fetal pleural effusions are being recognized more often and at earlier gestational ages." ; rdfs:label "Fetal pleural effusion"@en ; rdfs:subClassOf obo:HP_0034243 . obo:HP_0025677 obo:IAO_0000115 "The presence of chyle (a type of lipid-rich lymph) in the pleural space (the space surrounding the lung) as observed in a fetus." ; dcterms:creator ; a owl:Class ; rdfs:comment "Fetal chylothorax is associated with a high mortality rate. The most serious consequences of fetal chylothorax are pulmonary hypoplasia, congestive heart failure, and hydrops. It may occur as an isolated disorder or as a feature of diseases such as trisomy 21, Turner syndrome, and Noonan syndrome. Chylous pleural effusion impairs normal development of fetal lungs by pressure effects and can lead to pulmonary hypoplasia, mediastinal shift, and impaired circulation." ; rdfs:label "Fetal chylothorax"@en ; rdfs:subClassOf obo:HP_0025676 . obo:HP_0025678 obo:IAO_0000115 "Accumulation of lymphatic fluid in the pleural space. This finding is usually observed by prenatal sonography. Once neonatal feeding is established and the lymphatic fluid contains chyle, transformation to chylothorax may be observed." ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal hydrothorax"@en ; rdfs:subClassOf obo:HP_0025676 . obo:HP_0025679 obo:IAO_0000115 "Inflammation of an intervertebral disc or disk space." ; dcterms:creator ; oboInOwl:hasExactSynonym "Discitis" ; a owl:Class ; rdfs:label "Diskitis"@en ; rdfs:subClassOf obo:HP_0005108 . obo:HP_0025680 obo:IAO_0000115 "Compound muscle action potential amplitude (CMAP) facilitation denotes an increase in tendon reflexes, strength, or CMAP amplitude after 10 seconds of maximal voluntary contraction." ; dcterms:creator ; oboInOwl:hasExactSynonym "CMAP facilitation" ; a owl:Class ; rdfs:label "Compound muscle action potential amplitude facilitation"@en ; rdfs:subClassOf obo:HP_0030179 . obo:HP_0025681 obo:IAO_0000115 "Abnormally reduced diameter (cross section) of the clavicles that is limited to the distal region." ; dcterms:creator ; a owl:Class ; rdfs:label "Distal clavicular thinning"@en ; rdfs:subClassOf obo:HP_0006645 . obo:HP_0025682 obo:IAO_0000115 "A gait disturbance that is characterized by excessive ankle dorsiflexion, knee and hip flexion during the stance phase." ; dcterms:creator ; a owl:Class ; rdfs:comment "Crouch gait may be observed in individuals affected by cerebral palsy." ; rdfs:label "Crouch gait"@en ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0025683 obo:IAO_0000115 "Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta42, which is 42 amino acids in length, is the longer form." ; dcterms:creator ; a owl:Class ; rdfs:comment "The amyloid cascade hypothesis has been the prevailing paradigm for understanding Alzheimer's disease (AD) pathogenesis. According to this hypothesis, the fibrillogenic 42-amino acid beta amyloid peptide (Abeta42) aggregates into toxic beta-sheet rich assemblies, triggering a cascade of neurotoxic events, including intracellular tau accumulation as neurofibrillary tangles and neuroinflammation, which ultimately result in neurodegeneration and subsequent cognitive impairment." ; rdfs:label "Abnormal amyloid beta 42 peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025688 . obo:HP_0025684 obo:IAO_0000115 "A reduction from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF)." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased amyloid beta 42 peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025683 . obo:HP_0025685 obo:IAO_0000115 "An elevation above the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF)." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased amyloid beta 42 peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025683 . obo:HP_0025686 obo:IAO_0000115 "Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta40, which is 40 amino acids in length, is the shorter form." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal Abeta 40 level", "Abnormal beta amyloid 40 level" ; a owl:Class ; rdfs:label "Abnormal amyloid beta 40 peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025688 . obo:HP_0025687 obo:IAO_0000115 "An elevation above the normal concentration of amyloid beta 40 peptide in the cerebrospinal fluid (CSF)." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased amyloid beta 40 peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025686 . obo:HP_0025688 obo:IAO_0000115 "Any anomaly in the concentration of a cleaved APP amyloid beta protein fragment in the cerebrospinal fluid." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal amyloid beta peptide CSF concentration"@en ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0025689 obo:IAO_0000115 "Focal dilatation of the extra-abdominal portion of the umbilical vein. An extra-abdominal umbilical varix is difficult to diagnose prenatally as it can appear like a cyst on ultrasound prior to birth." ; dcterms:creator ; a owl:Class ; rdfs:comment "Intra-abdominal umbilical vein varix is defined to be 9 mm or greater in diameter or alternatively to have a diameter that is 50 percent wider than that of the intrahepatic umbilical vein." ; rdfs:label "Extra-abdominal umbilical vein varix"@en ; rdfs:subClassOf obo:HP_0030656 . obo:HP_0025690 obo:IAO_0000115 "Fetal intra-abdominal umbilical vein varix (FIUVV) is defined by the focal dilatation of the fetal umbilical vein between its entry in the abdomen and its ending in the portal system. The dilatation can be defined using one of the following criteria: a portion of intra-abdominal umbilical vein that is at least 50% wider than the non-dilated portion; a dilatation of 9 mm or more, or a dilatation greater than 2 SD above the mean value for gestational age." ; dcterms:creator ; oboInOwl:hasExactSynonym "FIUVV", "Fetal umbilical vein dilatation", "Foetal umbilical vein dilatation" ; a owl:Class ; rdfs:label "Fetal intra-abdominal umbilical vein varix"@en ; rdfs:subClassOf obo:HP_0030656 . obo:HP_0025691 obo:IAO_0000115 "Impaired fasting glucose (IFG) is indicated by a fasting plasma glucose above normal but below the diabetic range. Levels between 110 mg/dl (6.1 mmol/l) to 125 mg/dl (6.9 mmol/l) are diagnostic of IFG." ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired fasting glucose"@en ; rdfs:subClassOf obo:HP_0003074 . obo:HP_0025692 obo:IAO_0000115 "A defect of development of the brain characterized by absence of the telencephalon (embryonic structure from which the mature cerebrum develops)." ; dcterms:creator ; a owl:Class ; rdfs:comment """Atelencephaly can be differentiated from anencephaly by the presence of a skull and an intact scalp. Aprosencephaly is characterized by absence of the telencephalon and diencephalon (embryonic structure from which the thalamus develops). Atelencephaly is generally fatal.""" ; rdfs:label "Atelencephaly"@en ; rdfs:subClassOf obo:HP_0007364 . obo:HP_0025693 obo:IAO_0000115 "A pituitary gland adenoma that is larger than 10mm." ; dcterms:creator ; oboInOwl:hasExactSynonym "Pituitary gland macroadenoma" ; a owl:Class ; rdfs:comment "Pituitary macroadenoma presents with mass effects and potentially hormonal deficiency or hormonal excess." ; rdfs:label "Pituitary macroadenoma"@en ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0025694 obo:IAO_0000115 "A pituitary adenoma that is less than 10 mm in diameter." ; dcterms:creator ; a owl:Class ; rdfs:comment "Pituitary microadenoma is usually an incidental finding on brain MRI. Patients are asymptomatic unless the tumor is hormonally active." ; rdfs:label "Pituitary microadenoma"@en ; rdfs:subClassOf obo:HP_0002893 . obo:HP_0025695 obo:IAO_0000115 "Mucus that is abnormally thick in consistency (ie, inspissated) and plugs the airway is known as a mucus plug. Mucus plugs consist of mucins and cells and can partially or completely obstruct one or more airways and cause serious consequences, including atelectasis and recurrent infection." ; dcterms:creator ; a owl:Class ; rdfs:label "Mucus plug"@en ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0025696 obo:IAO_0000115 "A replicate of airways from accumulated and condensed mucous and cellular material. These semisolid occlusions take the shape of the airway within they are formed, leading to obstruction of the tracheobronchial tree with consecutive respiratory insufficiency. Based on their principal composition, one can differentiate fibrin casts and mucin casts. Plastic bronchitis is the name of the condition characterized by the formation of airway casts." ; dcterms:creator ; a owl:Class ; rdfs:comment "Casts are frequently (4-16%) observed in patients with congenital heart disease who have undergone Fontan palliation. Casts are infrequently observed in sickle cell disease-and acute chest syndrome, airway infections, in particular H1N1 influenza, severe asthma, or after smoke/chemical inhalation injuries." ; rdfs:label "Airway casts"@en ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0025697 obo:IAO_0000115 "A type of airway casts that consist of plasma components and inflammatory cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Cellular airway casts", "Diphtheroid membranes", "Pseudomembranes", "Type I airway casts" ; a owl:Class ; rdfs:label "Fibrin casts"@en ; rdfs:subClassOf obo:HP_0025696 . obo:HP_0025698 obo:IAO_0000115 "A type of airway casts that consist of impacted mucus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Acellular airway casts", "Type II airway casts" ; a owl:Class ; rdfs:label "Mucin casts"@en ; rdfs:subClassOf obo:HP_0025696 . obo:HP_0025699 obo:IAO_0000115 "18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (FDG-PET/CT) evaluates the glucose metabolism of the brain. FDG uptake is interpreted to represent glycolysis. This term therefore represents an abnormally increased FDG uptake (increased glucose metabolism) in the region of the brain that surrounds the Sylvian fissure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Perisylvian hypermetabolism in FDG PET" ; a owl:Class ; rdfs:label "Perisylvian FDG hypermetabolism"@en ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0025700 obo:IAO_0000115 "A complete or near-complete lack of amniotic fluid surrounding a fetus. This finding can be observed sonographically in the third trimesters if the deepest pocket of amniotic fluid is less than or equal to 2 cm." ; dcterms:creator ; a owl:Class ; rdfs:label "Anhydramnios"@en ; rdfs:subClassOf obo:HP_0001560 . obo:HP_0025701 obo:IAO_0000115 "The jugular lymphatic sacs (JLS) are a physiological and temporary part of fetal lymphatic development. They are formed from small buds of lymphatic endothelial cells arising from the internal jugular veins. By 14 weeks gestation they have developed into lymphatic nodes which drain into the systemic circulation. Visibility of JLS on ultrasound past 14 weeks of gestation implies distension and this may be associated with raised nuchal translucency." ; dcterms:creator ; a owl:Class ; rdfs:comment "Distended jugular lymphatic sacs (JLS) may pre-date or accompany raised nuchal translucency or cystic hygroma and are associated with the same range of disorders. These are largely chromosomal aneuploidies or significant copy number variation. Current evidence suggests distended JLS in the absence of raised nuchal translucency are likely to be normal variation." ; rdfs:label "Distended jugular lymphatic sacs"@en ; rdfs:subClassOf obo:HP_0025667 . obo:HP_0025702 obo:IAO_0000115 "A type of Schizencephaly in which there is a trans-mantle column of abnormal grey matter but no evidence of a CSF-containing cleft on MR imaging." ; dcterms:creator ; oboInOwl:hasExactSynonym "Trans-mantle schizencephaly" ; a owl:Class ; rdfs:label "Type 1 schizencephaly"@en ; rdfs:subClassOf obo:HP_0010636 . obo:HP_0025703 obo:IAO_0000115 "A type of Schizencephaly in which CSF-containing cleft is present with abutting lining lips of abnormal grey matter that are opposed to each other." ; dcterms:creator ; a owl:Class ; rdfs:comment "This is a milder form of schizecephaly that can be asymptomatic or diagnosed in adult patients." ; rdfs:label "Type 2 schizencephaly"@en ; rdfs:subClassOf obo:HP_0010636 . obo:HP_0025704 obo:IAO_0000115 "A type of Schizencephaly in which CSF-containing cleft present with non-abutting lining lips of abnormal grey matter." ; dcterms:creator ; a owl:Class ; rdfs:comment "This is a severe form of schizencephaly that can manifest by refractory epilepsy, intellectual disability, varying degrees of paralysis from hemiparesis to quadriparesis." ; rdfs:label "Type 3 schizencephaly"@en ; rdfs:subClassOf obo:HP_0010636 . obo:HP_0025705 obo:IAO_0000115 "Abnormal appearance or non-visualization (apparent absence) of the nasal bone of a fetus in first trimester sonographic screening. Assessment of the fetal nasal bone is generally performed at 11-14 weeks gestational age." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal nasal bone visualization"@en ; rdfs:subClassOf obo:HP_0025662 . obo:HP_0025706 obo:IAO_0000115 "The nasal bone is considered absent when it is not visualized on a midsagittal view of the profile. In the second trimester, a true midsagittal view of the fetal profile is obtained and magnified to fill the majority of the image space. The nasal bone appears as an echogenic linear structure below the skin edge. The optimal angle of insonation is 45 degrees to the longitudinal axis of the fetal nasal bone. If the angle of insonation is 0 or 180 degrees, the nasal bone may appear artificially absent. The presence or absence of the nasal bone may be determined at the time of the 11- to 14-week ultrasound examination and used as part of the risk assessment for aneuploidy." ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence of fetal nasal bone", "Absence of foetal nasal bone", "Unossified nasal bone" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:23324624." ; rdfs:label "Absent fetal nasal bone"@en ; rdfs:subClassOf obo:HP_0025705 . obo:HP_0025707 obo:IAO_0000115 "Length of the nasal bone below a predetermined cut-off as seen on antenatal ultrasound using standard imaging techniques." ; dcterms:creator ; a owl:Class ; rdfs:comment "Different studies have used different cut-offs to assess the length of nasal bone. Most data supports use of gestation and ethnicity specific centiles or MoMs. Hypoplastic nasal bone on antenatal ultrasound is one of the soft markers for Down syndrome. This marker can be used to adjust a-priori risk for Down syndrome and offer options for further diagnostic testing to the pregnant woman. Hypoplastic nasal bone can also rarely be a marker for submicroscopic copy number abnormalities and single gene disorders in the fetus." ; rdfs:label "Hypoplastic nasal bone"@en ; rdfs:subClassOf obo:HP_0025705 . obo:HP_0025708 obo:IAO_0000115 "Onset of disease at an age of greater than or equal to 16 to under 19 years." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term includes the full 16th year of age up to the completed 18th year of age (i.e., less than the 19th birthday)." ; rdfs:label "Early young adult onset"@en ; rdfs:subClassOf obo:HP_0011462 . obo:HP_0025709 obo:IAO_0000115 "Onset of disease at an age of greater than or equal to 19 to under 25 years." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term includes the full 19th year of age up to the completed 25th year of age (i.e., less than the 25th birthday)." ; rdfs:label "Intermediate young adult onset"@en ; rdfs:subClassOf obo:HP_0011462 . obo:HP_0025710 obo:IAO_0000115 "Onset of disease at an age of greater than or equal to 25 to under 40 years." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term includes the full 25th year of age up to the completed 40th year of age (i.e., less than the 40th birthday)." ; rdfs:label "Late young adult onset"@en ; rdfs:subClassOf obo:HP_0011462 . obo:HP_0025711 obo:IAO_0000115 "Convergence-retraction nystagmus is an irregular, jerky nystagmus in which both eyeballs rhythmically converge and retract into the orbit, particularly on attempting an upward gaze." ; dcterms:creator ; oboInOwl:hasExactSynonym "Convergence retraction nystagmus" ; a owl:Class ; rdfs:label "Convergence-retraction nystagmus"@en ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0025712 obo:IAO_0000115 "Persistence separation of the chorionic and amnionic membranes after the 16th week of gestation (not as a result of a procedure such as amniocentesis)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Amnion-chorion separation" ; a owl:Class ; rdfs:comment "The separation of the chorion and amnion before 14 weeks' of gestation is physiologically normal. The amnion and chorion usually fuse between 14 and 16 weeks, and any chorioamniotic separation (CAS) that persists after 16 weeks is uncommon and anomalous. CAS can occur spontaneously or after an intrauterine intervention such as amniocentesis, fetal blood sampling, or fetal surgery." ; rdfs:label "Spontaneous chorioamniotic separation"@en ; rdfs:subClassOf obo:HP_0011409 . obo:HP_0025713 obo:IAO_0000115 "Dystrophic neurites are abnormal neuronal processes characterized microscopically by aberrant sprouting, dystrophic expansion, and accumulation of various cellular organelles and cytoskeletal/signaling proteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Dystrophic neurite" ; a owl:Class ; rdfs:comment "Dystrophic neurites occur around neuritic plaques in the brains of subjects with Alzheimer's disease and various other neurological conditions." ; rdfs:label "Neurite dystrophy"@en ; rdfs:subClassOf obo:HP_0012757 . obo:HP_0025714 obo:IAO_0000115 "An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions." ; dcterms:creator ; a owl:Class ; rdfs:comment "See figure 1 of PMID:10867785." ; rdfs:label "Cerebral cortical microinfarct"@en ; rdfs:subClassOf obo:HP_0002538 . obo:HP_0025715 obo:IAO_0000115 "Abnormal waveforms the Doppler sonographic examination of bloodflow in the umbilical artery. vUmbilical arterial Doppler assessment is used in surveillance of fetal health in the third trimester." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0025658" ; a owl:Class ; rdfs:label "Abnormal umbilical artery doppler waveform during pregnancy"@en ; rdfs:subClassOf obo:HP_0025657 . obo:HP_0025716 obo:IAO_0000115 "Low hemoglobin/hematocrit in a fetus as evidenced by percutaneous umbilical cord sampling and Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery." ; dcterms:creator ; a owl:Class ; rdfs:comment "Fetal anemia has been known for many years as a dangerous complication of pregnancy. Its most common causes are maternal alloimmunization and parvovirus B19 infection, although it can be associated with many different pathological conditions including fetal aneuploidies, vascular tumors, and arteriovenous malformations of the fetus or placenta and inherited conditions such as alpha-thalassemia or genetic metabolic disorders. Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery for the diagnosis of fetal anemia and intravascular intrauterine transfusion for its treatment are the current practice standards." ; rdfs:label "Fetal anemia"@en ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0025717 obo:IAO_0000115 "Abnormal accumulation of autophagosomes in skeletal muscle tissue." ; dcterms:creator ; oboInOwl:hasExactSynonym "Autophagic material in muscle biopsy" ; a owl:Class ; rdfs:comment "Autophagy (self-eating) is a process of lysosomal degradation of long-lived proteins and damaged organelles. In macroautophagy (hereafter referred to as autophagy), double-membrane vesicles known as autophagosomes sequester cytoplasm and damaged organelles. The autophagosomes fuse with endosomes, giving rise to amphisomes, followed by fusion with lysosomes where degradation of autophagosomal contents is completed. Autophagy is a critical survival mechanism under conditions of nutrient deprivation and appears to play a role in basal protein turnover as well. Under normal conditions, autophagosomes and amphisomes are quickly degraded by lysosomes, and their content is recycled. In certain pathological states, significant accumulation of autophagosomes is observed." ; rdfs:label "Skeletal muscle autophagosome accumulation"@en ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0025718 obo:IAO_0000115 "An increased echo intensity of muscle tissue on sonography, defined as an increased amount of returning echoes per square area of muscle tissue. On cross-section, normal muscle appears as a relatively anechoic structure with hyperechoic speckles within the tissue representing perimysial septa, giving it a starry night appearance. The boundaries of each muscle are delineated by the presence of hyperechoic fascia. In muscle disorders, one of the hallmark findings is replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity from higher sound transitions in the muscle. This increase in echogenicity is most distinct in conditions that lead to chronic pathology, such as long-standing muscle inflammation, dystrophy, or denervation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperechoic muscle", "Muscle ultrasound hyperechogenicity" ; a owl:Class ; rdfs:label "Skeletal muscle hyperechogenicity"@en ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0025719 obo:IAO_0000115 "Gross findings of maternal vascular malperfusion include placental hypoplasia, placental infarction, and retroplacental hemorrhage. If information is available, it is preferable to annotate using the HPO terms that corresponding to the specific abnormalities." ; dcterms:creator ; a owl:Class ; rdfs:comment "Maternal vascular malperfusion (MVM) of the placental bed represents a recognizable pattern of placental injury related to altered uterine and intervillous blood flow. MVM consists of a constellation of placental pathologic findings seen in the maternal decidual vessels, reflecting abnormal spiral artery remodeling, as well as in the villous parenchyma, reflecting abnormalities in oxygenation and flow dynamics in the intervillous space." ; rdfs:label "Maternal vascular malperfusion"@en ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0025720 obo:IAO_0000115 "Limited mobility of the eye to move from side to side (horizontally) within its socket." ; dcterms:creator ; a owl:Class ; rdfs:label "Limited horizontal extraocular movement"@en ; rdfs:subClassOf obo:HP_0007941 . obo:HP_0025721 obo:IAO_0000115 "Limited mobility of the eye to move up and down (vertically) within its socket." ; dcterms:creator ; a owl:Class ; rdfs:label "Limited vertical extraocular movement"@en ; rdfs:subClassOf obo:HP_0007941 . obo:HP_0025722 obo:IAO_0000115 "A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors." ; dcterms:creator ; a owl:Class ; rdfs:label "Cerebral infarct"@en ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0025723 obo:IAO_0000115 "Any structural anomaly of the skin of the fetus or newborn. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal skin morphology"@en ; rdfs:subClassOf obo:HP_0011121, obo:HP_0034058 . obo:HP_0025724 obo:IAO_0000115 "Vernix caseosa is a physiological, viscous biofilm that is produced by desquamated fetal skin and sebaceous glands covering the fetus at the third trimester in-utero. The substance's gross morphology in post-partum is described by the etymology, as vernix means varnish, and caseosa means cheesy-like matter. This finding refers to an abnormally thick and greasy vernix caseosa-like scale present at birth." ; dcterms:creator ; oboInOwl:hasExactSynonym "Greasy, thick vernix caseosa-like scale" ; a owl:Class ; rdfs:label "Caseous vernix-like desquamation"@en ; rdfs:subClassOf obo:HP_0025723 . obo:HP_0025725 obo:IAO_0000115 "A type of congenital pulmonary airway malformation that is characterized by multiple large cysts or a single dominant cyst." ; dcterms:creator ; a owl:Class ; rdfs:label "Type 1 congenital pulmonary airway malformation"@en ; rdfs:subClassOf obo:HP_0010959 . obo:HP_0025726 obo:IAO_0000115 "A type of congenital pulmonary airway malformation that is characterized by multiple evenly spaced cysts (sponge-like appearance)." ; dcterms:creator ; a owl:Class ; rdfs:label "Type 2 congenital pulmonary airway malformation"@en ; rdfs:subClassOf obo:HP_0010959 . obo:HP_0025727 obo:IAO_0000115 "A type of congenital pulmonary airway malformation that is characterized by a bulky firm mass with an adenomatoid appearance." ; dcterms:creator ; a owl:Class ; rdfs:label "Type 3 congenital pulmonary airway malformation"@en ; rdfs:subClassOf obo:HP_0010959 . obo:HP_0025728 obo:IAO_0000115 "Pseudocysts that lack an epithelial lining, PVPCs are frequently observed in the caudothalamic groove or in the infero-lateral aspect of the frontal horns of the lateral ventricles, but may also be located elsewhere along the periventricular germinal matrix, as in the temporal or occipital horns." ; dcterms:creator ; a owl:Class ; rdfs:comment "Previously, periventricular leukomalacia and periventricular pseudocysts (PVPC) have been confused. PVPC are found below the external angle of the lateral ventricles whereas periventricular leukomalacia is located above it and has a different prognosis." ; rdfs:label "Periventricular pseudocyst"@en ; rdfs:subClassOf obo:HP_0002518 . obo:HP_0025729 obo:IAO_0000115 "The term fetal vascular malperfusion (FVM) is used to describe placental pathology that is throught to result from an obstruction in fetal blood flow that could result from a number of conditions (eg, umbilical cord lesions, hypercoagulability, complications of fetal cardiac dysfunction, such as hypoxia, etc.)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Findings consistent with FVM are thrombosis, segmental avascular villi, and villous stromal-vascular karyorrhexis. Other possible markers include vascular intramural fibrin deposition, stem vessel obliteration/fibromuscular sclerosis, and vascular ectasia. If data are available it is preferable to annotate the individual phenotypic features with specific HPO terms." ; rdfs:label "Fetal vascular malperfusion"@en ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0025730 obo:IAO_0000115 "Foramen ovale aneurysm (FOA) or atrial septal aneurysm is abnormal redundancy of the atrial septum primum, with bulging of the septum by at least half the width of the atrial chamber, or by at least 10 mm beyond the level of the atrial septum. The abnormal protrusion of the interatrial septum results in decreased left atrial volume. On color Doppler there is reduced left ventricular inflow." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fetal atrial septal dilatation", "Foetal atrial septal dilatation", "Redundant septum primum flap" ; a owl:Class ; rdfs:comment "The reported incidence of foramen ovale aneurysm (FOA) in preterm and term infants is 11.1% and 7.1%, respectively. Postnatally, most atrial septal aneurysms resolve spontaneously as the pressure in the left atrium increases and compresses the septum against the foramen ovale. However, atrial septal aneurysms may be associated with other cardiac anomalies including atrial septum defect, patent foramen ovale, and mitral valve prolapse. In the absence of other cardiac anomalies or arrhythmia, the prognosis for FOA is excellent. See figure 7 of PMID:30601441." ; rdfs:label "Foramen ovale aneurysm"@en ; rdfs:subClassOf obo:HP_0010948 . obo:HP_0030000 obo:IAO_0000115 "Abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz." ; oboInOwl:hasDbXref "UMLS:C4022681" ; a owl:Class ; rdfs:label "EMG: repetitive nerve stimulation abnormality" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0030001 obo:IAO_0000115 "A condition in which the eyelids do not close to cover the eye completely." ; oboInOwl:hasDbXref "UMLS:C4022680" ; oboInOwl:hasExactSynonym "Eyelids stay open", "Inability to close the eyelids" ; a owl:Class ; rdfs:comment "Some common causes of lagophthalmos are Bell's palsy and other types of facial paralysis, stroke, infection, and trauma. The inability to blink and effectively close the eyes leads to corneal exposure and excessive evaporation of the tear film. The main purpose when treating lagophthalmos is to prevent exposure keratitis and reestablish eyelid function." ; rdfs:label "Lagophthalmos" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0030002 obo:IAO_0000115 "The inability to close the eyelids during sleep." ; oboInOwl:hasDbXref "SNOMEDCT_US:417740005", "UMLS:C1563118" ; oboInOwl:hasExactSynonym "Eyelids stay open at night", "Inability to close the eyelids at night" ; a owl:Class ; rdfs:comment "Lagophthalmos is associated with exposure keratopathy, poor sleep, and persistent exposure-related symptoms. There are a variety of causes of lagophthalmos, grouped as proptosis/eye exposure etiologies and palpebral insufficiency etiologies." ; rdfs:label "Nocturnal lagophthalmos" ; rdfs:subClassOf obo:HP_0030001 . obo:HP_0030003 obo:IAO_0000115 "A type of lagophthalmos that occurs in association with facial nerve palsy." ; oboInOwl:hasDbXref "SNOMEDCT_US:59890007", "UMLS:C0155197" ; a owl:Class ; rdfs:comment "Patients with facial nerve palsy have a characteristic facial asymmetry and drooping of the angle of mouth. The temporal and zygomatic branches of facial nerve supply the forehead and eyelid muscles. Their involvement in a disease leads to paralysis of orbicularis oculi muscle resulting in lagophthalmos and ectropion." ; rdfs:label "Paralytic lagophthalmos" ; rdfs:subClassOf obo:HP_0030001 . obo:HP_0030004 obo:IAO_0000115 "A type of lagophthalmos that occurs following trauma or surgery." ; oboInOwl:hasDbXref "SNOMEDCT_US:9042000", "UMLS:C0155199" ; oboInOwl:hasExactSynonym "Eyelids stay open due to scarring", "Inability to close the eyelids due to scarring" ; a owl:Class ; rdfs:label "Cicatricial lagophthalmos" ; rdfs:subClassOf obo:HP_0030001 . obo:HP_0030005 obo:IAO_0000115 "An acute phenomenon characterized by hypotension and anasarca due to the loss of plasma volume into peripheral tissues, with evidence of decreased plasma volume (hemoconcentration) and protein loss from the intravascular space (hypoalbuminemia) during acute episodes." ; oboInOwl:hasDbXref "MSH:D019559", "SNOMEDCT_US:1608005", "SNOMEDCT_US:87730004", "UMLS:C0343084", "UMLS:C1382398" ; oboInOwl:hasExactSynonym "Increased capillary permeability" ; oboInOwl:hasRelatedSynonym "Systemic capillary leak syndrome" ; a owl:Class ; rdfs:label "Capillary leak" ; rdfs:subClassOf obo:HP_0025018 . obo:HP_0030006 obo:IAO_0000115 "Abnormality in single fiber EMG recording, a technique that allows identification of action potentials (APs) from individual muscle fibers." ; oboInOwl:hasDbXref "UMLS:C4022679" ; oboInOwl:hasExactSynonym "Single fibre EMG abnormality" ; a owl:Class ; rdfs:label "Single fiber EMG abnormality" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0030007 obo:IAO_0000115 "These are spontaneous firing action potentials stimulated by needle movement of an injured muscle fiber. There is propagation to, but not past, the needle tip. This inhibits the display of the negative deflection of the waveform." ; oboInOwl:hasDbXref "SNOMEDCT_US:251527008", "UMLS:C0429349" ; a owl:Class ; rdfs:label "EMG: positive sharp waves" ; rdfs:subClassOf obo:HP_0003482 . obo:HP_0030008 obo:IAO_0000115 "Congenital absence of the cervix." ; oboInOwl:hasDbXref "SNOMEDCT_US:37687000", "UMLS:C0266404" ; oboInOwl:hasExactSynonym "Absent cervix", "Aplasia of the cervix", "Cervical aplasia" ; a owl:Class ; rdfs:label "Cervical agenesis" ; rdfs:subClassOf obo:HP_0012888 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030009 obo:IAO_0000115 "A cervix that shows a painless dilation and shortening during the second trimester of pregnancy with resultant recurrent pregnancy loss or delivery is considered incompetent" ; oboInOwl:hasDbXref "MSH:D002581", "SNOMEDCT_US:17382005", "UMLS:C0007871" ; oboInOwl:hasExactSynonym "Incompetent cervix" ; a owl:Class ; rdfs:comment "One of the known risk factors for preterm birth is cervical insufficiency." ; rdfs:label "Cervical insufficiency" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0030010 obo:IAO_0000115 "Hydrometrocolpos is an accumulation of uterine and vaginal secretions as well as menstrual blood in the uterus and vagina." ; oboInOwl:hasDbXref "SNOMEDCT_US:60023006", "UMLS:C0269209" ; a owl:Class ; rdfs:comment "Usually hydrometrocolpos manifests at puberty caused by an obstruction of the female genital tract.The most frequent cause of hydrometrocolpos is the presence of imperforate hymen due to failure of partial resorption of this membrane during the embryonic development." ; rdfs:label "Hydrometrocolpos" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0030011 obo:IAO_0000115 "A congenital disorder where the hymen (a membrane that surrounds or partially covers the external vaginal opening) does not have an opening and completely obstructs the vagina." ; oboInOwl:hasDbXref "MSH:C562397", "SNOMEDCT_US:65937002", "UMLS:C0152436" ; a owl:Class ; rdfs:comment "Imperformate hymen is caused by a failure of the hymen to perforate during fetal development. It is most often diagnosed in adolescent girls when menstrual blood accumulates in the vagina and sometimes also in the uterus. It can be treated by surgical incision of the hymen." ; rdfs:label "Imperforate hymen" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0030012 oboInOwl:hasDbXref "UMLS:C4020714", "UMLS:C4022678" ; oboInOwl:hasExactSynonym "Abnormal female reproductive system physiology" ; oboInOwl:hasRelatedSynonym "Abnormal female genital system physiology" ; a owl:Class ; rdfs:label "Abnormal female reproductive system physiology" ; rdfs:subClassOf obo:HP_0000080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030013 obo:IAO_0100001 "HP:0030127" ; a owl:Class ; rdfs:label "obsolete Endometriosis" ; owl:deprecated true . obo:HP_0030014 obo:IAO_0000115 "A problem occurring during any phase of the female sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity" ; oboInOwl:hasDbXref "UMLS:C1112442" ; a owl:Class ; rdfs:label "Female sexual dysfunction" ; rdfs:subClassOf obo:HP_0030012 . obo:HP_0030015 obo:IAO_0000115 "The persistent of recurrent difficulty, delay in, or absence of attaining orgasm following sufficient sexual stimulation and arousal." ; oboInOwl:hasBroadSynonym "Female orgasmic disorder" ; oboInOwl:hasDbXref "SNOMEDCT_US:60103007", "UMLS:C0033948", "UMLS:C4022677" ; a owl:Class ; rdfs:label "Female anorgasmia" ; rdfs:subClassOf obo:HP_0030014, obo:HP_0046502 . obo:HP_0030016 obo:IAO_0000115 "Recurrent or persistent genital pain associated with sexual intercourse." ; oboInOwl:hasDbXref "MSH:D004414", "SNOMEDCT_US:71315007", "UMLS:C1384606" ; a owl:Class ; rdfs:comment "Dyspareunia can develop secondary to medical problems such as vestibulitis, vaginal atrophy, or vaginal infection. It can be either physiologically or psychologically based, or a combination of the two." ; rdfs:label "Dyspareunia" ; rdfs:subClassOf obo:HP_0030014 . obo:HP_0030017 obo:IAO_0000115 "Recurrent or persistent involuntary spasms of the musculature of the outer third of the vagina that interferes with vaginal penetration, and which causes personal distress." ; oboInOwl:hasDbXref "MSH:D052065", "SNOMEDCT_US:79012001", "UMLS:C2004487" ; oboInOwl:hasExactSynonym "Myalgia of pelvic floor", "Pelvic floor myalgia" ; a owl:Class ; rdfs:comment "Vaginismus usually develops as a conditioned response to painful penetration, or secondary to psychological/emotional factors." ; rdfs:label "Vaginismus" ; rdfs:subClassOf obo:HP_0030014 . obo:HP_0030018 obo:IAO_0000115 "Dminished sexual desire in female." ; oboInOwl:hasDbXref "UMLS:C4022676" ; oboInOwl:hasExactSynonym "Decreased female sex drive" ; a owl:Class ; rdfs:label "Decreased female libido" ; rdfs:subClassOf obo:HP_0030014, obo:HP_0046504 . obo:HP_0030019 obo:IAO_0000115 "Elevated sexual desire in female" ; oboInOwl:hasDbXref "UMLS:C4022675" ; oboInOwl:hasExactSynonym "Increased female sex drive" ; a owl:Class ; rdfs:label "Increased female libido" ; rdfs:subClassOf obo:HP_0030014, obo:HP_0046503 . obo:HP_0030021 obo:IAO_0000115 "Small protrusion within the pinna." ; oboInOwl:hasDbXref "UMLS:C4022674" ; a owl:Class ; rdfs:comment "The tag can be located on either side of the pinna." ; rdfs:label "Auricular tag" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030022 obo:IAO_0000115 "Cleft between the helix and the lobe." ; oboInOwl:hasDbXref "UMLS:C3888103" ; oboInOwl:hasExactSynonym "Constricted ear", "Cosman ear", "Question mark ear", "Question mark ears" ; a owl:Class ; rdfs:comment "Relatively few cases have been reported. Variation from a small notch to complete separation of the helix from the lobe is noted, there may be unilateral or bilateral involvement. The lobe is relatively laterally recessed compared to the upper portion of the ear and the scapha may be absent. This is distinct from a Cleft helix where the cleft is within the helix." ; rdfs:label "Question mark ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030023 obo:IAO_0000115 "Small cartilaginous prominence on the posterior concha." ; oboInOwl:hasDbXref "UMLS:C4022673" ; a owl:Class ; rdfs:comment "This feature is best visualized when the earlobe is tilted anteriorly." ; rdfs:label "Quelprud nodule" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030024 obo:IAO_0000115 "Variably shaped, cartilage-containing tissue anterior to the external auditory meatus." ; oboInOwl:hasDbXref "SNOMEDCT_US:204245004", "UMLS:C0266609" ; oboInOwl:hasNarrowSynonym "Extra cartilage in front of the ear" ; oboInOwl:hasRelatedSynonym "Accessory Tragus", "Pretragal Duplication" ; a owl:Class ; rdfs:comment "Pretragal ectopia refers to structures that are frequently complex and should be distinguished from preauricular tags. They may be difficult to distinguish from striated muscle hamartomas or tragal duplications. Pretragal ectopias often appear helix-like, and in such cases may be called Polyotia." ; rdfs:label "Pretragal ectopia" ; rdfs:subClassOf obo:HP_0000383 . obo:HP_0030025 obo:IAO_0000115 "Small indentation in the lower part of the ascending helix, concha, or in the crus helix." ; oboInOwl:hasDbXref "UMLS:C4022672" ; a owl:Class ; rdfs:comment "The location of the pits is the plane of fusion of the first branchial cleft." ; rdfs:label "Auricular pit" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030026 obo:IAO_0000115 "Flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual." ; oboInOwl:hasDbXref "UMLS:C4022671" ; a owl:Class ; rdfs:comment "This is not to be confused with Lop ear or Satyr ear and may represent an underdevelopment of the upper third of the pinna. This is usually associated with a short ascending helix." ; rdfs:label "Squared superior portion of helix" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0030027 obo:IAO_0000115 "A morphological anomaly of the nasal cartilage." ; oboInOwl:hasDbXref "UMLS:C4022670" ; oboInOwl:hasExactSynonym "Abnormality of cartilage of nose", "Abnormality of the nasal cartilage", "Anomaly of cartilage of nose", "Anomaly of nasal cartilage" ; oboInOwl:hasNarrowSynonym "Deformity of cartilage of nose", "Deformity of nasal cartilage", "Malformation of cartilage of nose", "Malformation of nasal cartilage" ; a owl:Class ; rdfs:label "Abnormal nasal cartilage morphology" ; rdfs:subClassOf obo:HP_0010938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030028 obo:IAO_0000115 "Lack of a palpable nasal cartilage." ; oboInOwl:hasDbXref "MSH:C562753", "SNOMEDCT_US:232381002", "UMLS:C4022669", "UMLS:C4082198" ; oboInOwl:hasExactSynonym "Absent cartilage of nose", "Absent nasal cartilage", "Agenesis of cartilage of nose", "Agenesis of nasal cartilage", "Failure of development of cartilage of nose", "Failure of development of nasal cartilage", "Missing cartilage of nose", "Missing nasal cartilage" ; a owl:Class ; rdfs:comment "This feature may be accompanied by a deficiency of the nasal bone. Absence of the nasal cartilage may lead to a Depressed nasal tip, which should be coded separately." ; rdfs:label "Absent nasal cartilage" ; rdfs:subClassOf obo:HP_0030027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030029 obo:IAO_0000115 "Divergence of digits along the A/P axis (in the plane of the palm)." ; oboInOwl:hasDbXref "UMLS:C4021057" ; oboInOwl:hasExactSynonym "Splayed fingers", "Spreading of the fingers" ; a owl:Class ; rdfs:comment "This may be associated with Macrodactyly, but this should be assessed and coded separately. The affected digits should be specified." ; rdfs:label "Splayed fingers" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0030030 obo:IAO_0000115 "The absence of all phalanges of a digit and the associated metacarpal /metatarsal." ; oboInOwl:hasDbXref "UMLS:C4022668" ; a owl:Class ; rdfs:comment "This descriptor requires, in addition to the absence of the phalanges, absence of the metacarpal or metatarsal. Compare this to Absent thumb, Absent hallux, Absent toes, and Absent fingers. In most cases, the absent metacarpal or metatarsal can be assessed by palpation, but in some cases radiographs may be useful. This definition excludes Split hand and Split foot. If a patient meets the definition of either of those terms, they should be used and Absent ray should not." ; rdfs:label "Absent ray" ; rdfs:subClassOf obo:HP_0002813 . obo:HP_0030031 obo:IAO_0000115 "Significant reduction in both length and girth of the toe compared to the contralateral toe, or alternatively, compared to a typical toe size for an age-matched individual." ; oboInOwl:hasDbXref "UMLS:C4022667" ; oboInOwl:hasExactSynonym "Small toe" ; a owl:Class ; rdfs:comment "This is an acknowledged bundled term. There are no standards for this finding, clinical judgment must be used. The affected toes should be numbered." ; rdfs:label "Small toe" ; rdfs:subClassOf obo:HP_0001991 . obo:HP_0030032 obo:IAO_0000115 "An incomplete absence of the foot, with no bony elements distal to the tarsals, but with preservation of some or all of the tarsals." ; oboInOwl:hasDbXref "UMLS:C4022666" ; oboInOwl:hasExactSynonym "Partial absence of foot" ; a owl:Class ; rdfs:label "Partial absence of foot" ; rdfs:subClassOf obo:HP_0006494 . obo:HP_0030033 obo:IAO_0000115 "Significant reduction in both length and girth of the finger compared to the contralateral finger, or alternatively, compared to a typical finger size for an age-matched individual." ; oboInOwl:hasDbXref "SNOMEDCT_US:299058009", "UMLS:C0575827" ; oboInOwl:hasExactSynonym "Small finger" ; a owl:Class ; rdfs:comment "This is a bundled term, comprising Short finger and Slender digit, but it is so widely used that it is included. This term is only used if the finger has the normal number of phalangeal segments. An appropriate alternative term for the first digit is Small thumb, when it is the only digit affected. When a thumb and one or more fingers are affected, it may be more economical to specify Small fingers, F1-5 instead of separately specifying Small thumb and Small fingers F2-5." ; rdfs:label "Small finger" ; rdfs:subClassOf obo:HP_0006265 . obo:HP_0030034 obo:IAO_0000115 "Presence of abnormal additional layers of the basement membrane of the glomerulus." ; oboInOwl:hasDbXref "UMLS:C3278307" ; oboInOwl:hasExactSynonym "Lamellated/basket-woven thickened glomerular basement membranes", "Lamellation of the glomerular basement membrane" ; a owl:Class ; rdfs:label "Glomerular basement membrane lamellation" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0030035 obo:IAO_0000115 "Presence of struvite (magnesium ammonium phosphate) containing calculi (kidney stones)." ; oboInOwl:hasDbXref "UMLS:C4021056" ; oboInOwl:hasExactSynonym "Struvite kidney stones" ; a owl:Class ; rdfs:label "Struvite nephrolithiasis" ; rdfs:subClassOf obo:HP_0000787 . obo:HP_0030036 obo:IAO_0000115 "Inability of the kidneys to produce either concentrated or dilute urine." ; oboInOwl:hasDbXref "UMLS:C4022665" ; a owl:Class ; rdfs:comment "Isothenuria is seen in the final stages of renal failure. It reflects rapid flushing of fluid through the tubules in renal failure as the number of functioning nephrons decreases; the normal concentrating (particularly) and diluting mechanisms of the kidney do not have time to function. The consequence is that the specific gravity of the urine becomes approximately the same as that of the glomerular filtrate." ; rdfs:label "Isothenuria" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0030037 obo:IAO_0000115 "Incomplete duplication of the ureter." ; oboInOwl:hasDbXref "UMLS:C3887498" ; a owl:Class ; rdfs:label "Bifid ureter" ; rdfs:subClassOf obo:HP_0000073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030038 obo:IAO_0000115 "A solitary, benign, intramedullary cartilage tumor that is often found in the short tubular bones of the hands and feet, distal femur, and proximal humerus." ; oboInOwl:hasDbXref "MSH:D002812", "SNOMEDCT_US:31186001", "SNOMEDCT_US:423699002", "UMLS:C1704356" ; a owl:Class ; rdfs:comment "Most patients have no symptoms. Enchondromas are often identified as incidental findings on X-ray examinations. Enchondromas usually have a radiographic appearance that is long and oval with well-defined margins." ; rdfs:label "Enchondroma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0030039 obo:IAO_0000115 "A congenital anomaly characterized by a joining (fusion) of two or more thoracic vertebral bodies with one another." ; oboInOwl:hasDbXref "UMLS:C4022664" ; a owl:Class ; rdfs:label "Fused thoracic vertebrae" ; rdfs:subClassOf obo:HP_0002948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030040 obo:IAO_0000115 "A congenital anomaly characterized by a joining (fusion) of two or more lumbar vertebral bodies with one another." ; oboInOwl:hasDbXref "UMLS:C4022663" ; a owl:Class ; rdfs:label "Fused lumbar vertebrae" ; rdfs:subClassOf obo:HP_0002948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030041 obo:IAO_0000115 "A Schmorl's node is the herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of the adjacent vertebra." ; oboInOwl:hasDbXref "SNOMEDCT_US:45181002", "UMLS:C0410632" ; oboInOwl:hasExactSynonym "Schmorl's nodes" ; a owl:Class ; rdfs:comment "Schmorl's nodes (SN) are common findings on imaging, and although most SNs are asymptomatic, some have been shown to become painful lesions." ; rdfs:label "Schmorl's node" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0030042 obo:IAO_0000115 "Failure to complete ossification (maturation and calcification) of the pubic bone." ; oboInOwl:hasDbXref "SNOMEDCT_US:373940002", "UMLS:C0685678" ; oboInOwl:hasRelatedSynonym "Incomplete maturation of the pubic bone" ; a owl:Class ; rdfs:label "Incomplete ossification of pubis" ; rdfs:subClassOf obo:HP_0009105 . obo:HP_0030043 obo:IAO_0000115 "A partial dislocation of the hip joint, whereby the head of the femur is partially displaced from the socket." ; oboInOwl:hasDbXref "SNOMEDCT_US:263057000", "UMLS:C0434785" ; oboInOwl:hasExactSynonym "Partial hip dislocation", "Subluxation involving the hip joint" ; a owl:Class ; rdfs:label "Hip subluxation" ; rdfs:subClassOf obo:HP_0001384 . obo:HP_0030044 obo:IAO_0000115 "A bent (flexed) finger or toe joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." ; oboInOwl:hasDbXref "UMLS:C1839864" ; a owl:Class ; rdfs:label "Flexion contracture of digit" ; rdfs:subClassOf obo:HP_0001371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030045 obo:IAO_0000115 "Elongated curved (S-shaped) fibulae." ; oboInOwl:hasDbXref "UMLS:C3805325" ; oboInOwl:hasExactSynonym "S-shaped calf bone" ; a owl:Class ; rdfs:label "Serpentine fibula" ; rdfs:subClassOf obo:HP_0002991 . obo:HP_0030046 obo:IAO_0000115 "A reduction in the degree of glycosylation of alpha-dystroglycan in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C4015098" ; a owl:Class ; rdfs:comment "Alpha-dystroglycan is a component of the Dystrophin Associated Protein complex (DAP) which binds to various ligands in the extracellular matrix of muscle and other tissues, including laminin-alpha2, perlecan, neurexin and agrin. Disruption of the interaction between alpha-dystroglycan and its ligands has severe consequences for muscle and brain function and structure. The pathological hallmark is reduced immunolabeling of skeletal muscle with antibodies recognizing glycosylated epitopes on alpha-dystroglycan." ; rdfs:label "Hypoglycosylation of alpha-dystroglycan" ; rdfs:subClassOf obo:HP_0030112 . obo:HP_0030047 obo:IAO_0000115 "A morphological anomaly of the lateral ventricle." ; oboInOwl:hasDbXref "UMLS:C4022662" ; oboInOwl:hasExactSynonym "Abnormality of lateral ventricle" ; a owl:Class ; rdfs:comment "There are two lateral ventricles, one on each side of the brain. The lateral ventricle resembles a C-shaped structure that begins at an inferior horn in the temporal lobe, travels through a body in the parietal lobe and frontal lobe, and ultimately terminates at the interventricular foramen of Monro where each lateral ventricle connects to the central third ventricle." ; rdfs:label "Abnormal lateral ventricle morphology" ; rdfs:subClassOf obo:HP_0002118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002285 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030048 obo:IAO_0000115 "Colpocephaly is an anatomic finding in the brain manifested by occipital horns that are disproportionately enlarged in comparison with other parts of the lateral ventricles." ; oboInOwl:hasDbXref "MSH:C535973", "SNOMEDCT_US:253160006", "UMLS:C0431384" ; a owl:Class ; rdfs:label "Colpocephaly" ; rdfs:subClassOf obo:HP_0030047 . obo:HP_0030049 obo:IAO_0000115 "A collection of pus, immune cells, and other material in the brain." ; oboInOwl:hasDbXref "MSH:D001922", "SNOMEDCT_US:441806004", "UMLS:C0006105" ; oboInOwl:hasExactSynonym "Brain abscess" ; a owl:Class ; rdfs:comment "Brain abscess usually results from a bacterial or fungal infection." ; rdfs:label "Brain abscess" ; rdfs:subClassOf obo:HP_0011450, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030050 obo:IAO_0000115 "An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis." ; oboInOwl:hasDbXref "MSH:D009290", "SNOMEDCT_US:60380001", "UMLS:C0027404" ; a owl:Class ; rdfs:comment "There are two distinct groups of patients with narcolepsy, ie, those having narcolepsy with cataplexy and those having narcolepsy without cataplexy." ; rdfs:label "Narcolepsy" ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0030051 obo:IAO_0000115 "An abnormal gait pattern characterized by the failure of the heel to contact the floor at the onset of stance during gait." ; oboInOwl:hasAlternativeId "HP:0002394", "HP:0040083" ; oboInOwl:hasDbXref "UMLS:C1843570" ; oboInOwl:hasExactSynonym "Tiptoe gait", "Toe walking", "Walking on tiptoes" ; a owl:Class ; rdfs:comment "Tip-toe walking (or simply toe-walking) is common in healthy young children, and should resolve spontaneously by 3 years of age. After this age, tip-toe gait must be differentiated from habitual toe gait, congenital short tendo calcaneus, cerebral palsy, syringomyelia, spinal tumor, hematoma in a lower limb muscle, or neuromuscular diseases like muscular dystrophy, Charcot-Marie-Tooth disease and hereditary sensorimotor neuropathies. If the toe gait persists for 2-3 years, this gait pattern is not considered to be habitual. Therefore, the judgment of habitual toe gait should not be determined without evaluation for other diseases." ; rdfs:label "Tip-toe gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0030052 obo:IAO_0000115 "The presence in the inguinal region (groin) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin." ; oboInOwl:hasDbXref "UMLS:C1834297" ; oboInOwl:hasExactSynonym "Freckles in groin region" ; a owl:Class ; rdfs:label "Inguinal freckling" ; rdfs:subClassOf obo:HP_0001480 . obo:HP_0030053 obo:IAO_0000115 "An induration (hardening) of the skin" ; oboInOwl:hasDbXref "UMLS:C3276815" ; oboInOwl:hasExactSynonym "Indurated skin", "Stiff skin" ; a owl:Class ; rdfs:label "Stiff skin" ; rdfs:subClassOf obo:HP_0011121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000386 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030054 obo:IAO_0000115 "Presence of excess fibrous connective tissue surrounding hair follicules." ; oboInOwl:hasDbXref "UMLS:C2748531" ; a owl:Class ; rdfs:label "Perifollicular fibrosis" ; rdfs:subClassOf obo:HP_0031285 . obo:HP_0030055 obo:IAO_0000115 "When viewed on end (with the tip of the toe pointing toward the examiner's eye) the curve of the toenail forms a tighter curve of convexity." ; oboInOwl:hasDbXref "UMLS:C4022661" ; a owl:Class ; rdfs:label "Hyperconvex toenail" ; rdfs:subClassOf obo:HP_0001795 . obo:HP_0030056 obo:IAO_0000115 "Hair that is disorderly, stands out from the scalp, and cannot be combed flat." ; oboInOwl:hasDbXref "UMLS:C1860607" ; oboInOwl:hasExactSynonym "Uncombable hair" ; a owl:Class ; rdfs:label "Uncombable hair" ; rdfs:subClassOf obo:HP_0010719 . obo:HP_0030057 obo:IAO_0000115 "The presence of an antibody in the blood circulation that is directed against the organism's own cells or tissues." ; oboInOwl:hasDbXref "UMLS:C4022660" ; a owl:Class ; rdfs:label "Autoimmune antibody positivity" ; rdfs:subClassOf obo:HP_0002960 . obo:HP_0030058 obo:IAO_0000115 "An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains)." ; oboInOwl:hasDbXref "UMLS:C2237347" ; a owl:Class ; rdfs:label "Sickled erythrocytes" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0030059 obo:IAO_0000115 "An abnormal reduction in mitochondrial DNA content of cells." ; oboInOwl:hasDbXref "UMLS:C4022659" ; a owl:Class ; rdfs:label "Mitochondrial depletion" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0030060 obo:IAO_0000115 "A neoplasm derived from nervous tissue (not necessarily a neoplasm located in the nervous system)." ; oboInOwl:hasDbXref "MSH:D009380", "UMLS:C0027665" ; a owl:Class ; rdfs:label "Nervous tissue neoplasm" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0030061 obo:IAO_0000115 "A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells." ; oboInOwl:hasDbXref "MSH:D017599", "SNOMEDCT_US:253096008", "SNOMEDCT_US:73676002", "UMLS:C0206093" ; a owl:Class ; rdfs:label "Neuroectodermal neoplasm" ; rdfs:subClassOf obo:HP_0030060 . obo:HP_0030062 obo:IAO_0000115 "A benign pituitary-region neoplasm that originates from Rathke's pouch. Craniopharyngiomas are benign slow growing tumors that are located within the sellar and para sellar region of the central nervous system." ; oboInOwl:hasDbXref "MSH:D003397", "SNOMEDCT_US:189179009", "SNOMEDCT_US:40009002", "UMLS:C0010276" ; a owl:Class ; rdfs:comment "Patients may present with bitemporal inferior quadrantanopia leading to bitemporal hemianopia, since the tumor may compress the optic chiasm." ; rdfs:label "Craniopharyngioma" ; rdfs:subClassOf obo:HP_0030061 . obo:HP_0030063 obo:IAO_0000115 "A neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium." ; oboInOwl:hasDbXref "MSH:D018302", "UMLS:C0206715" ; a owl:Class ; rdfs:label "Neuroepithelial neoplasm" ; rdfs:subClassOf obo:HP_0030061 . obo:HP_0030064 obo:IAO_0000115 "A benign brain tumor composed of neural elements which most often arise from the septum pellucidum and the walls of the lateral ventricles." ; oboInOwl:hasDbXref "MSH:D018306", "SNOMEDCT_US:128858006", "UMLS:C1622510" ; a owl:Class ; rdfs:comment "Immunohistochemistry and electron microscopy evaluations may reveal expression of neuron specific enolase and synaptophysin and cells containing microtubuli, neurosecretory granules, and presynaptic vesicles." ; rdfs:label "Neurocytoma" ; rdfs:subClassOf obo:HP_0030063 . obo:HP_0030065 obo:IAO_0000115 "A tumor that originates in cells from the primitive neural crest. This group of tumors is characteirzed by the presence of primitive cells with elements of neuronal and/or glial differentiation." ; oboInOwl:hasDbXref "MSH:D018242", "SNOMEDCT_US:39781001", "SNOMEDCT_US:55045006", "SNOMEDCT_US:699028006", "UMLS:C0206663" ; oboInOwl:hasExactSynonym "Primitive neuroectodermal tumour" ; a owl:Class ; rdfs:label "Primitive neuroectodermal tumor" ; rdfs:subClassOf obo:HP_0030063 . obo:HP_0030066 obo:IAO_0000115 "A highly malignant embryonal tumor of infancy and young childhood characterized by neuroectodermal elements organized in distinctive multilayered rosettes. Ependymoblastomas are large lesions that occur in the supratentorial compartment, typically displaying a physical connection to the ventricular system." ; oboInOwl:hasDbXref "MSH:D018242", "SNOMEDCT_US:21589007", "SNOMEDCT_US:715901002", "UMLS:C0700367" ; a owl:Class ; rdfs:comment "Ependymoblastoma is a rare tumor that occurs in infants and young children in the first two years of life. Both sexes are affected equally. Patients present with signs and symptoms of raised intracranial pressure and hydrocephalus. Focal neurological signs may be present in older children. On MRI, ependymoblastomas are large heterogeneously enhancing lesion with associated brain edema and mass effect. Ependymoblastomas are well-circumscribed lesions, with a distinct margin between tumor and normal brain, though focal microscopic extension and leptomeningeal invasion are common. Histologically, an ependymoblastoma is a primitive neuroectodermal tumor with tumor cell arranged in multilayered rosettes consisting of an outer rim of tumor cells merging with the surrounding undifferentiated neuroectodermal cells. The tumor cells are immunopositive for S100, vimentin, cytokeratin and GFAP, and show high mitotic activity." ; rdfs:label "Ependymoblastoma" ; rdfs:subClassOf obo:HP_0030070 . obo:HP_0030067 obo:IAO_0000115 "A primitive neuroectodermal neoplasm that occurs extracranially in soft tissue and bone." ; oboInOwl:hasDbXref "MSH:D018241", "SNOMEDCT_US:253096008", "SNOMEDCT_US:703707001", "SNOMEDCT_US:73676002", "UMLS:C0684337" ; a owl:Class ; rdfs:label "Peripheral primitive neuroectodermal neoplasm" ; rdfs:subClassOf obo:HP_0030065 . obo:HP_0030068 obo:IAO_0000115 "A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate." ; oboInOwl:hasDbXref "MSH:D018304", "SNOMEDCT_US:422886007", "SNOMEDCT_US:68614005", "SNOMEDCT_US:76060004", "UMLS:C0206717" ; a owl:Class ; rdfs:label "Olfactory esthesioneuroblastoma" ; rdfs:subClassOf obo:HP_0003006 . obo:HP_0030069 obo:IAO_0000115 "A form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type that originates in the brain, leptomeninges, spinal cord, or eyes and typically remains confined to the CNS." ; oboInOwl:hasDbXref "SNOMEDCT_US:21964009", "SNOMEDCT_US:307649006", "UMLS:C0280803" ; oboInOwl:hasExactSynonym "Primary CNS lymphoma" ; a owl:Class ; rdfs:comment "Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, cerebrospinal fluid, eyes or spinal cord by an extranodal non-Hodgkin lymphoma (NHL) without evidence of a systemic lymphoma at the time of diagnosis. It represents 0.8 to 6.6% of all primary CNS tumors" ; rdfs:label "Primary central nervous system lymphoma" ; rdfs:subClassOf obo:HP_0012539 . obo:HP_0030070 obo:IAO_0000115 "A primitive neuroectodermal neoplasm that occurs in the central nervous system." ; oboInOwl:hasDbXref "SNOMEDCT_US:39781001", "UMLS:C3887678" ; oboInOwl:hasExactSynonym "Central primitive neuroectodermal tumour" ; a owl:Class ; rdfs:label "Central primitive neuroectodermal tumor" ; rdfs:subClassOf obo:HP_0030065 . obo:HP_0030071 obo:IAO_0000115 "A primitive neuroectodermal tumor that originates from the cells of the embryonic medullary canal." ; oboInOwl:hasDbXref "MSH:D018242", "SNOMEDCT_US:39005004", "SNOMEDCT_US:715903004", "UMLS:C0334596" ; a owl:Class ; rdfs:comment "Medulloepithelioma is a rare primitive neuroectodermal tumor of the central nervous system usually developing in childhood, displaying highly malignant behaviour, with early progression or recurrence." ; rdfs:label "Medulloepithelioma" ; rdfs:subClassOf obo:HP_0030070 . obo:HP_0030072 obo:IAO_0000115 "A tumor that originates in the paranasal sinus." ; oboInOwl:hasDbXref "MSH:D010255", "NCIT:C3262", "SNOMEDCT_US:126675008", "UMLS:C0030470" ; oboInOwl:hasExactSynonym "Neoplasm of the paranasal sinuses" ; oboInOwl:hasNarrowSynonym "Tumor of the paranasal sinuses", "Tumour of the paranasal sinuses" ; a owl:Class ; rdfs:label "Paranasal sinus neoplasm" ; rdfs:subClassOf obo:HP_0000245, obo:HP_0012720 . obo:HP_0030073 obo:IAO_0100001 "HP:0100638" ; a owl:Class ; rdfs:label "obsolete Pharyngeal neoplasm" ; owl:deprecated true . obo:HP_0030074 obo:IAO_0000115 "A usually benign neoplasm originating in the chemoreceptor tissue of the carotid body, glomus jugulare, glomus tympanicum, aortic bodies, or the female genital tract." ; oboInOwl:hasDbXref "MSH:D002345", "SNOMEDCT_US:127028003", "SNOMEDCT_US:30699005", "UMLS:C0007279" ; oboInOwl:hasExactSynonym "Chemodectomas" ; a owl:Class ; rdfs:label "Chemodectoma" ; rdfs:subClassOf obo:HP_0002668 . obo:HP_0030075 obo:IAO_0000115 "Presence of abnormal cells inside a milk duct, that is, non-invasive breast cancer. Ductal carcinoma in situ is considered to be a precursor lesion to invasive breast cancer." ; oboInOwl:hasDbXref "MSH:D002285", "SNOMEDCT_US:109889007", "SNOMEDCT_US:278053004", "SNOMEDCT_US:373176000", "SNOMEDCT_US:86616005", "UMLS:C0007124" ; a owl:Class ; rdfs:label "Ductal carcinoma in situ" ; rdfs:subClassOf obo:HP_0100013 . obo:HP_0030076 oboInOwl:hasDbXref "MSH:D000071960", "SNOMEDCT_US:109888004", "UMLS:C0279563" ; a owl:Class ; rdfs:label "Lobular carcinoma in situ" ; rdfs:subClassOf obo:HP_0100013 . obo:HP_0030077 obo:IAO_0000115 "A tumor originating in a bronchus." ; oboInOwl:hasDbXref "MSH:D001984", "NCIT:C3262", "SNOMEDCT_US:126705004", "UMLS:C0006264" ; a owl:Class ; rdfs:label "Bronchial neoplasm" ; rdfs:subClassOf obo:HP_0025426, obo:HP_0100552 . obo:HP_0030078 oboInOwl:hasDbXref "MSH:C538231", "NCIT:C2852", "SNOMEDCT_US:254626006", "UMLS:C0152013" ; a owl:Class ; rdfs:label "Lung adenocarcinoma" ; rdfs:subClassOf obo:HP_0030358 . obo:HP_0030079 obo:IAO_0000115 "A tumor of the uterine cervix." ; oboInOwl:hasDbXref "MSH:D002583", "NCIT:C3262", "SNOMEDCT_US:363354003", "UMLS:C4048328" ; a owl:Class ; rdfs:label "Cervix cancer" ; rdfs:subClassOf obo:HP_0032241 . obo:HP_0030080 obo:IAO_0000115 "A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass." ; oboInOwl:hasDbXref "MSH:D002051", "SNOMEDCT_US:118617000", "SNOMEDCT_US:22197008", "SNOMEDCT_US:277571004", "SNOMEDCT_US:397400006", "SNOMEDCT_US:77381001", "UMLS:C0006413" ; a owl:Class ; rdfs:label "Burkitt lymphoma" ; rdfs:subClassOf obo:HP_0012539 . obo:HP_0030081 obo:IAO_0000115 "Multiple pointlike areas of high T2 signal observed upon magnetic resonance imaging of the periventricular cerebral white matter." ; oboInOwl:hasDbXref "UMLS:C4022658" ; a owl:Class ; rdfs:label "Punctate periventricular T2 hyperintense foci" ; rdfs:subClassOf obo:HP_0002518, obo:HP_0030891 . obo:HP_0030082 obo:IAO_0000115 "Abnormal consumption of fluids with excessive or insufficient consumption of fluid or any other abnormal pattern of fluid consumption." ; oboInOwl:hasDbXref "UMLS:C4022657" ; oboInOwl:hasExactSynonym "Abnormal drinking behavior", "Abnormal drinking behaviour" ; a owl:Class ; rdfs:comment "Note that this HPO term refers to an abnormal habit of drinking fluids but does not directly refer to an psychological disorder." ; rdfs:label "Abnormal drinking behavior" ; rdfs:subClassOf obo:HP_0040202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042756 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030083 obo:IAO_0000115 "An excessive desire to eat salt (sodium chloride) or salty foods." ; oboInOwl:hasDbXref "UMLS:C0240928" ; oboInOwl:hasExactSynonym "Salt craving" ; a owl:Class ; rdfs:comment "Salt craving can be a sign of low salt levels, Addison's disease, Gitelman syndrome, and other diseases." ; rdfs:label "Salt craving" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0030084 obo:IAO_0000115 "An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe)." ; oboInOwl:hasBroadSynonym "Curvature of digit" ; oboInOwl:hasDbXref "SNOMEDCT_US:17268007", "UMLS:C0265610", "UMLS:C4280304" ; oboInOwl:hasExactSynonym "Permanent curving of the finger" ; a owl:Class ; rdfs:label "Clinodactyly" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030085 obo:IAO_0000115 "Abnormal concentration of lactate in the cerebrospinal fluid." ; oboInOwl:hasDbXref "UMLS:C4022656" ; oboInOwl:hasExactSynonym "Abnormal CSF lactate level" ; a owl:Class ; rdfs:label "Abnormal CSF lactate concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030086 obo:IAO_0000115 "Decreased concentration of lactate in the cerebrospinal fluid." ; oboInOwl:hasDbXref "UMLS:C4022655" ; oboInOwl:hasExactSynonym "Hypolactatorachia" ; a owl:Class ; rdfs:label "Reduced CSF lactate" ; rdfs:subClassOf obo:HP_0030085 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030087 obo:IAO_0000115 "An anomalous concentration of testosterone in the blood." ; dcterms:creator ; oboInOwl:hasBroadSynonym "Abnormal testosterone level" ; oboInOwl:hasDbXref "SNOMEDCT_US:166458009", "UMLS:C0580454", "UMLS:C4022654" ; oboInOwl:hasExactSynonym "Abnormal serum testosterone level" ; a owl:Class ; rdfs:label "Abnormal circulating testosterone concentration" ; rdfs:subClassOf obo:HP_0030347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17347 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030088 obo:IAO_0000115 "An elevated circulating testosterone level in the blood." ; dcterms:creator ; oboInOwl:hasBroadSynonym "Increased testosterone" ; oboInOwl:hasDbXref "UMLS:C0241358", "UMLS:C4072885" ; oboInOwl:hasExactSynonym "High serum testosterone level", "High serum testosterone levels", "Increased serum testosterone levels" ; a owl:Class ; rdfs:label "Increased serum testosterone level" ; rdfs:subClassOf obo:HP_0030087, obo:HP_0030348 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17347 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030089 obo:IAO_0000115 "An anomalous amount of protein present in or on the surface of muscle fibers. This feature may be appreciate upon immunohistochemical investigation of muscle biopsy tissue." ; oboInOwl:hasDbXref "UMLS:C4022653" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre protein expression" ; a owl:Class ; rdfs:label "Abnormal muscle fiber protein expression" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0008002 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030090 obo:IAO_0000115 "An anomalous amount of merosin in muscle fibers. Merosin is a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve." ; oboInOwl:hasDbXref "UMLS:C4022652" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre merosin expression" ; a owl:Class ; rdfs:label "Abnormal muscle fiber merosin expression" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030091 obo:IAO_0000115 "Lack of merosin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4021055" ; oboInOwl:hasExactSynonym "Absent merosin staining in muscle biopsy", "Absent muscle fiber laminin alpha 2", "Absent muscle fibre laminin alpha 2", "Absent muscle fibre merosin" ; a owl:Class ; rdfs:label "Absent muscle fiber merosin" ; rdfs:subClassOf obo:HP_0030090 . obo:HP_0030092 obo:IAO_0000115 "A reduced amount of merosin in muscle fibers. This feature is usually assessed by immunohistochemical examination of muscle biopsy tissue." ; oboInOwl:hasDbXref "UMLS:C4022651" ; oboInOwl:hasExactSynonym "Reduced muscle fibre merosin" ; a owl:Class ; rdfs:label "Reduced muscle fiber merosin" ; rdfs:subClassOf obo:HP_0030090 . obo:HP_0030093 obo:IAO_0000115 "A deviation from normal of the amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1." ; oboInOwl:hasDbXref "UMLS:C4022650" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre laminin beta 1" ; a owl:Class ; rdfs:label "Abnormal muscle fiber laminin beta 1" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030094 obo:IAO_0000115 "A reduced amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1." ; oboInOwl:hasDbXref "UMLS:C4022649" ; oboInOwl:hasExactSynonym "Reduced muscle fibre laminin beta 1" ; a owl:Class ; rdfs:label "Reduced muscle fiber laminin beta 1" ; rdfs:subClassOf obo:HP_0030093 . obo:HP_0030095 obo:IAO_0000115 "A decreased amount of collagen VI in muscle tissue. Collagen VI is a primarily associated with the extracellular matrix of skeletal muscle." ; oboInOwl:hasDbXref "UMLS:C4021054" ; oboInOwl:hasExactSynonym "Reduced collagen 6 in muscle" ; a owl:Class ; rdfs:label "Reduced muscle collagen VI" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030096 obo:IAO_0000115 "A deviation from normal in the amount of dystrophin in muscle fiber tissue. Dystrophin is located at the muscle sarcolemma in a membrane-spanning protein complex that connects the cytoskeleton to the basal lamina." ; oboInOwl:hasDbXref "UMLS:C4022648" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre dystrophin expression" ; a owl:Class ; rdfs:label "Abnormal muscle fiber dystrophin expression" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030097 obo:IAO_0000115 "Lack of dystrophin in muscle tissue. Immunohistochemistry reveals absent dystrophin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022647" ; a owl:Class ; rdfs:label "Absent muscle dystrophin expression" ; rdfs:subClassOf obo:HP_0030096 . obo:HP_0030098 obo:IAO_0000115 "A decreased amount of dystrophin in muscle fiber tissue." ; oboInOwl:hasDbXref "UMLS:C4021053" ; oboInOwl:hasExactSynonym "Reduced dystrophin staining in muscle" ; a owl:Class ; rdfs:label "Reduced muscle dystrophin expression" ; rdfs:subClassOf obo:HP_0030096 . obo:HP_0030099 obo:IAO_0000115 "Immunohistochemistry reveals reduced alpha dystroglycan protein in the muscle biopsy. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly." ; oboInOwl:hasDbXref "UMLS:C4022646" ; oboInOwl:hasExactSynonym "Reduced muscle fibre alpha dystroglycan" ; a owl:Class ; rdfs:label "Reduced muscle fiber alpha dystroglycan" ; rdfs:subClassOf obo:HP_0030112 . obo:HP_0030100 obo:IAO_0000115 "Deviation from normal in the amount of alpha sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." ; oboInOwl:hasDbXref "UMLS:C4022645" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre alpha sarcoglycan" ; a owl:Class ; rdfs:label "Abnormal muscle fiber alpha sarcoglycan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030101 obo:IAO_0000115 "Lack of alpha sarcoglycan in muscle. Immunohistochemistry reveals absent alpha sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022644" ; oboInOwl:hasExactSynonym "Absent muscle fibre alpha sarcoglycan" ; a owl:Class ; rdfs:label "Absent muscle fiber alpha sarcoglycan" ; rdfs:subClassOf obo:HP_0030100 . obo:HP_0030102 obo:IAO_0000115 "A decreased amount of alpha sarcoglycan in muscle. Immunohistochemistry reveals reduced alpha sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022643" ; oboInOwl:hasExactSynonym "Reduced muscle fibre alpha sarcoglycan" ; a owl:Class ; rdfs:label "Reduced muscle fiber alpha sarcoglycan" ; rdfs:subClassOf obo:HP_0030100 . obo:HP_0030103 obo:IAO_0000115 "Deviation from normal in the amount of beta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." ; oboInOwl:hasDbXref "UMLS:C4022642" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre beta sarcoglycan" ; a owl:Class ; rdfs:label "Abnormal muscle fiber beta sarcoglycan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030104 obo:IAO_0000115 "Deviation from normal in the amount of gamma sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." ; oboInOwl:hasDbXref "UMLS:C4022641" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre gamma sarcoglycan" ; a owl:Class ; rdfs:label "Abnormal muscle fiber gamma sarcoglycan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030105 obo:IAO_0000115 "Deviation from normal in the amount of delta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." ; oboInOwl:hasDbXref "UMLS:C4022640" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre delta sarcoglycan" ; a owl:Class ; rdfs:label "Abnormal muscle fiber delta sarcoglycan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030106 obo:IAO_0000115 "Immunohistochemistry shows complete lack of beta sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022639" ; oboInOwl:hasExactSynonym "Absent muscle fibre beta sarcoglycan" ; a owl:Class ; rdfs:label "Absent muscle fiber beta sarcoglycan" ; rdfs:subClassOf obo:HP_0030103 . obo:HP_0030107 obo:IAO_0000115 "Immunohistochemistry reveals reduced beta sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022638" ; oboInOwl:hasExactSynonym "Reduced muscle fibre beta sarcoglycan" ; a owl:Class ; rdfs:label "Reduced muscle fiber beta sarcoglycan" ; rdfs:subClassOf obo:HP_0030103 . obo:HP_0030108 obo:IAO_0000115 "Immunohistochemistry reveals reduced gamma sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022637" ; oboInOwl:hasExactSynonym "Reduced muscle fibre gamma sarcoglycan" ; a owl:Class ; rdfs:label "Reduced muscle fiber gamma sarcoglycan" ; rdfs:subClassOf obo:HP_0030104 . obo:HP_0030109 obo:IAO_0000115 "Immunohistochemistry shows complete lack of gamma sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022636" ; oboInOwl:hasExactSynonym "Absent muscle fibre gamma sarcoglycan" ; a owl:Class ; rdfs:label "Absent muscle fiber gamma sarcoglycan" ; rdfs:subClassOf obo:HP_0030104 . obo:HP_0030110 obo:IAO_0000115 "Immunohistochemistry shows complete lack of delta sarcoglycan protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022635" ; oboInOwl:hasExactSynonym "Absent muscle fibre delta sarcoglycan" ; a owl:Class ; rdfs:label "Absent muscle fiber delta sarcoglycan" ; rdfs:subClassOf obo:HP_0030105 . obo:HP_0030111 obo:IAO_0000115 "Abnormally reduced amount of delta sarcoglycan in muscle." ; oboInOwl:hasDbXref "UMLS:C4022634" ; oboInOwl:hasExactSynonym "Reduced muscle fibre delta sarcoglycan" ; a owl:Class ; rdfs:label "Reduced muscle fiber delta sarcoglycan" ; rdfs:subClassOf obo:HP_0030105 . obo:HP_0030112 obo:IAO_0000115 "A deviation from normal of muscle alpha-dystroglcan expression. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly." ; oboInOwl:hasDbXref "UMLS:C4022633" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre alpha dystroglycan" ; a owl:Class ; rdfs:label "Abnormal muscle fiber alpha dystroglycan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030113 obo:IAO_0000115 "A deviation from normal in the expression of dysferlin in muscle tissue. Dysferlin is an ubiquitous 230-kDa transmembrane protein involved in calcium-mediated sarcolemma resealing." ; oboInOwl:hasDbXref "UMLS:C4022632" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre dysferlin" ; a owl:Class ; rdfs:label "Abnormal muscle fiber dysferlin" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030114 obo:IAO_0000115 "Immunohistochemistry shows complete lack of dysferlin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022631" ; oboInOwl:hasExactSynonym "Absent muscle fibre dysferlin" ; a owl:Class ; rdfs:label "Absent muscle fiber dysferlin" ; rdfs:subClassOf obo:HP_0030113 . obo:HP_0030115 obo:IAO_0000115 "Immunohistochemistry reveals reduced dysferlin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022630" ; oboInOwl:hasExactSynonym "Reduced muscle fibre dysferlin" ; a owl:Class ; rdfs:label "Reduced muscle fiber dysferlin" ; rdfs:subClassOf obo:HP_0030113 . obo:HP_0030116 obo:IAO_0000115 "A deviation from normal of the amount of the inner nuclear membrane protein emerin in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C4022629" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre emerin" ; a owl:Class ; rdfs:label "Abnormal muscle fiber emerin" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030117 obo:IAO_0000115 "Immunohistochemistry shows complete lack of emerin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022628" ; oboInOwl:hasExactSynonym "Absent muscle fibre emerin" ; a owl:Class ; rdfs:label "Absent muscle fiber emerin" ; rdfs:subClassOf obo:HP_0030116 . obo:HP_0030118 obo:IAO_0000115 "Immunohistochemistry reveals reduced emerin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022627" ; oboInOwl:hasExactSynonym "Reduced muscle fibre emerin" ; a owl:Class ; rdfs:label "Reduced muscle fiber emerin" ; rdfs:subClassOf obo:HP_0030116 . obo:HP_0030119 obo:IAO_0000115 "A deviation from normal in the amount of calpain-3 in muscle tissue. Calpains are intracellular nonlysosomal cysteine proteases modulated by calcium ions. A typical calpain is a heterodimer composed of two distinct subunits, one large (over 80 kDa) and the other small (30 kDa). While only one gene encoding the small subunit has been demonstrated, there are many genes for the large one. CAPN3 is similar to ubiquitous Calpain 1 and 2 (m-calpain and micro-calpain), but contains specific insertion sequences (NS, IS1 and IS2). Calpains cleave target proteins to modify their properties, rather than breaking down the substrates." ; oboInOwl:hasDbXref "UMLS:C4022626" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre calpain-3" ; a owl:Class ; rdfs:label "Abnormal muscle fiber calpain-3" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030120 obo:IAO_0000115 "Western blot shows complete lack of calpain-3 protein in the muscle biopsy tissue." ; oboInOwl:hasDbXref "UMLS:C4022625" ; oboInOwl:hasExactSynonym "Absent muscle fibre calpain-3" ; a owl:Class ; rdfs:label "Absent muscle fiber calpain-3" ; rdfs:subClassOf obo:HP_0030119 . obo:HP_0030121 obo:IAO_0000115 "Western blot reveals reduced calpain-3 protein in the muscle biopsy tissue." ; oboInOwl:hasDbXref "UMLS:C4022624" ; oboInOwl:hasExactSynonym "Reduced muscle fibre calpain-3" ; a owl:Class ; rdfs:label "Reduced muscle fiber calpain-3" ; rdfs:subClassOf obo:HP_0030119 . obo:HP_0030122 obo:IAO_0000115 "Immunohistochemistry reveals reduced perlecan protein in the muscle biopsy. Perlecan is a basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) also known as heparan sulfate proteoglycan 2 (HSPG2)." ; oboInOwl:hasDbXref "UMLS:C4022623" ; oboInOwl:hasExactSynonym "Reduced muscle fibre perlecan" ; a owl:Class ; rdfs:label "Reduced muscle fiber perlecan" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030123 obo:IAO_0000115 "A deviation from the normal amount of lamin A/C in muscle tissue. The LMNA gene gives rise to at least three splicing isoforms including the two main isoforms, lamin A and lamin C. These are constitutive components of the fibrous nuclear lamina and have different roles, ranging from mechanical nuclear membrane maintenance to gene regulation." ; oboInOwl:hasDbXref "UMLS:C4022622" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre lamin A/C" ; a owl:Class ; rdfs:label "Abnormal muscle fiber lamin A/C" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030124 obo:IAO_0000115 "A decreased amount of lamin A/C in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue." ; oboInOwl:hasDbXref "UMLS:C4022621" ; oboInOwl:hasExactSynonym "Reduced muscle fibre lamin A/C" ; a owl:Class ; rdfs:label "Reduced muscle fiber lamin A/C" ; rdfs:subClassOf obo:HP_0030123 . obo:HP_0030125 obo:IAO_0000115 "A congenital anomaly, in which the transverse process of the last lumbar vertebra (L5) fuses to the sacrum on one side or both, or to ilium, or both." ; oboInOwl:hasDbXref "UMLS:C4021052" ; oboInOwl:hasExactSynonym "L5 sacralization" ; a owl:Class ; rdfs:comment "This anomaly is observed at about 3.5 percent of people and is usually bilateral." ; rdfs:label "Sacralization of the fifth lumbar vertebra" ; rdfs:subClassOf obo:HP_0002948 . obo:HP_0030126 obo:IAO_0000115 "An anomaly of the inner mucous membrane of the uterus." ; oboInOwl:hasDbXref "UMLS:C4022620" ; oboInOwl:hasExactSynonym "Abnormality of the endometrium" ; a owl:Class ; rdfs:label "Abnormal endometrium morphology" ; rdfs:subClassOf obo:HP_0031105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001295 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030127 obo:IAO_0000115 "The growth of endometrial tissue outside the uterus." ; oboInOwl:hasAlternativeId "HP:0030013" ; oboInOwl:hasDbXref "MSH:D004715", "SNOMEDCT_US:129103003", "SNOMEDCT_US:396224008", "UMLS:C0014175" ; a owl:Class ; rdfs:comment "The main manifestations of endometriosis are chronic upper abdominal pain and infertility. Endometriosis occurs primarily on the pelvic peritoneum, ovaries, and rectovaginal septum, and in rare cases on the diaphragm, pleura, and pericardium. Endometriosis affects 6 to 10% of women of reproductive age, 50 to 60% of women and teenage girls with pelvic pain, and up to 50% of women with infertility. Peritoneal disease, which is dependent on estrogen for growth, derives from retrograde menstruation of steroid hormone sensitive endometrial cells and tissues, which implant on peritoneal surfaces and elicit an inflammatory response. This response is accompanied by angiogenesis, adhesions, fibrosis, scarring, neuronal infiltration, and anatomical distortion resulting in pain and infertility." ; rdfs:label "Endometriosis" ; rdfs:subClassOf obo:HP_0030012, obo:HP_0030126 . obo:HP_0030129 obo:IAO_0000115 "Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma." ; oboInOwl:hasDbXref "UMLS:C4022619" ; a owl:Class ; rdfs:comment "Ristocetin induced platelet agglutination (RIPA) is similar to the Ristocetin Cofactor Assay but RIPA measures platelet agglutination induced by Ristocetin-mediated VWF binding to the platelet Gp1b receptor. WITH RIPA, the ristocetin is added directly to the patient's platelet rich plasma and there are no serial dilutions of the plasma sample." ; rdfs:label "Impaired ristocetin cofactor assay activity" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0030130 obo:IAO_0000115 "Reduced ability of von Willebrand factor (vWF) to bind collagen. Abnormal response to collagen as manifested by reduced or lacking ability of plasma von WIllebrand Factor to bind collagen. An ELISA-based assay is typically used; the test is sensitive to loss of von Willebrand Factor high molecular weight multimers." ; oboInOwl:hasDbXref "UMLS:C4022618" ; a owl:Class ; rdfs:comment "This abnormality may be seen in von Willebrand disease type 1, type 2A, type 2B, and type 3." ; rdfs:label "Impaired von Willebrand factor collagen binding activity" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0030131 obo:IAO_0000115 "Deviation from the normal von Willebrand factor multimer pattern." ; oboInOwl:hasDbXref "UMLS:C4022617" ; a owl:Class ; rdfs:label "Abnormal von Willebrand factor multimer distribution" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0030132 obo:IAO_0000115 "Absence of large von Willebrand Factor multimers on gel electrophoresis." ; oboInOwl:hasDbXref "UMLS:C4022616" ; a owl:Class ; rdfs:comment "Type 2B von Willebrand disease is characterized by lack of large von Willebrand factor multimers with an otherwise normal von Willebrand factor multimer pattern." ; rdfs:label "Absence of large von Willebrand factor multimers" ; rdfs:subClassOf obo:HP_0030131 . obo:HP_0030133 obo:IAO_0000115 "Detection of abnormal ultra-large von Willebrand factor multimers." ; oboInOwl:hasDbXref "UMLS:C4022615" ; a owl:Class ; rdfs:comment "The type Vicenza variant of von Willebrand disease (VWD) is characterized by a low plasma von Willebrand factor (VWF) level and supranormal VWF multimers." ; rdfs:label "Abnormal presence of ultra-large von Willebrand factor multimers" ; rdfs:subClassOf obo:HP_0030131 . obo:HP_0030134 obo:IAO_0000115 "Complete absence of all von Willebrand factor multimers." ; oboInOwl:hasDbXref "UMLS:C4022614" ; a owl:Class ; rdfs:label "Total absence von Willebrand factor multimers" ; rdfs:subClassOf obo:HP_0030131 . obo:HP_0030135 obo:IAO_0000115 "Lack of intermediate von Willebrand Factor multimers on gel electrophoresis." ; oboInOwl:hasDbXref "UMLS:C4022613" ; a owl:Class ; rdfs:comment "Type 2A von Willebrand disease is characterized by the absence of large and intermediate von Willebrand Factor multimers on gel electrophoresis, with preservation of an otherwise normal multimer pattern." ; rdfs:label "Absence of intermediate von Willebrand factor multimers" ; rdfs:subClassOf obo:HP_0030131 . obo:HP_0030136 obo:IAO_0000115 "Abnormal response to ristocetin as manifested by increased aggregation of platelets upon addition of low-dose ristocetin to platelet-rich plasma." ; oboInOwl:hasDbXref "UMLS:C4022612" ; a owl:Class ; rdfs:comment "This abnormality is characteristic of type 2B von Willebrand disease." ; rdfs:label "Enhanced ristocetin cofactor assay activity" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0030137 obo:IAO_0000115 "Bleeding that persists for a longer than usual time following circumcision." ; oboInOwl:hasDbXref "UMLS:C4022611" ; oboInOwl:hasExactSynonym "Prolonged bleeding following circumcision" ; a owl:Class ; rdfs:label "Prolonged bleeding following circumcision" ; rdfs:subClassOf obo:HP_0011890 . obo:HP_0030138 obo:IAO_0000115 "An abnormally increased degree of bleeding following a superfical injury to the surface of the skin." ; oboInOwl:hasDbXref "UMLS:C4022610" ; oboInOwl:hasExactSynonym "Excessive bleeding from superficial cuts" ; a owl:Class ; rdfs:label "Excessive bleeding from superficial cuts" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0030139 obo:IAO_0000115 "An abnormal high amount of bleeding following the procedure of taking a blood sample." ; oboInOwl:hasDbXref "UMLS:C4022609" ; a owl:Class ; rdfs:label "Excessive bleeding after a venipuncture" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0030140 obo:IAO_0000115 "Recurrent or excessive bleeding from the mouth." ; oboInOwl:hasDbXref "UMLS:C4022608" ; oboInOwl:hasExactSynonym "Bleeding from mouth", "Oral cavity bleeding", "Oral cavity haemorrhage", "Oral cavity hemorrhage" ; a owl:Class ; rdfs:label "Oral cavity bleeding" ; rdfs:subClassOf obo:HP_0001892, obo:HP_0031815 . obo:HP_0030141 obo:IAO_0000115 "An anomaly in the placement or shape of the hairline (trichion) on the back of the head (neck), that is, the border between skin on the back of the head that has head hair." ; oboInOwl:hasDbXref "UMLS:C4022607" ; oboInOwl:hasExactSynonym "Abnormality of hairline at back of head" ; a owl:Class ; rdfs:label "Abnormality of the posterior hairline" ; rdfs:subClassOf obo:HP_0009553 . obo:HP_0030142 obo:IAO_0000115 "An anomaly of the amount or nature of abdominal sounds. Abdominal sounds (bowel sounds) are made by the movement of the intestines as they promote passage of abdominal contents by peristalsis." ; oboInOwl:hasDbXref "SNOMEDCT_US:60612008", "UMLS:C0159060" ; oboInOwl:hasExactSynonym "Abnormal bowel sounds" ; a owl:Class ; rdfs:label "Abnormal bowel sounds" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0030143 obo:IAO_0000115 "Abnormally increased gurgling/rumbling sounds made by the movement of fluid and gas in the intestines." ; oboInOwl:hasDbXref "SNOMEDCT_US:18101008", "UMLS:C0232694" ; oboInOwl:hasExactSynonym "Borborygmi", "Increased bowel sounds" ; a owl:Class ; rdfs:label "Hyperactive bowel sounds" ; rdfs:subClassOf obo:HP_0030142 . obo:HP_0030144 obo:IAO_0000115 "An decreased amount of bowel sounds." ; oboInOwl:hasDbXref "SNOMEDCT_US:15280003", "UMLS:C0232695" ; oboInOwl:hasExactSynonym "Decreased bowel sounds" ; a owl:Class ; rdfs:label "Hypoactive bowel sounds" ; rdfs:subClassOf obo:HP_0030142 . obo:HP_0030145 obo:IAO_0000115 "Complete lack of abdominal sounds as assayed by examination of the abdomen with a stethoscope." ; oboInOwl:hasDbXref "UMLS:C4022606" ; oboInOwl:hasExactSynonym "Lack of bowel sounds" ; a owl:Class ; rdfs:comment "This feature reflects lack of intestinal activity." ; rdfs:label "Lack of bowel sounds" ; rdfs:subClassOf obo:HP_0030142 . obo:HP_0030146 obo:IAO_0000115 "A structural anomaly of the liver located predominantly in the hepatocytes as opposed to stromal cells." ; oboInOwl:hasDbXref "UMLS:C4022605" ; a owl:Class ; rdfs:label "Abnormal liver parenchyma morphology" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001280 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030147 obo:IAO_0000115 "Tremor of the trunk in an anterior-posterior plane at 3-4 Hz." ; oboInOwl:hasDbXref "UMLS:C2674512" ; a owl:Class ; rdfs:label "Truncal titubation" ; rdfs:subClassOf obo:HP_0030187 . obo:HP_0030148 obo:IAO_0000115 "An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart." ; oboInOwl:hasDbXref "MSH:D006337", "SNOMEDCT_US:414786004", "SNOMEDCT_US:421493004", "SNOMEDCT_US:88610006", "UMLS:C0018808" ; oboInOwl:hasExactSynonym "Cardiac murmur", "Cardiac murmurs", "Heart murmur", "Heart murmurs" ; a owl:Class ; rdfs:comment "Heart murmurs can be appreciated by auscultation of the heart by stethoscope. Murmurs can be further categorized by intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc)." ; rdfs:label "Heart murmur" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0030149 obo:IAO_0000115 "Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume." ; oboInOwl:hasDbXref "MSH:D012770", "SNOMEDCT_US:89138009", "UMLS:C0036980" ; oboInOwl:hasExactSynonym "Cardiovascular shock" ; a owl:Class ; rdfs:comment "Cardiogenic shock can result from a number of different of cardiac insults, the most common of which is acute myocardial infarction." ; rdfs:label "Cardiogenic shock" ; rdfs:subClassOf obo:HP_0031273 . obo:HP_0030150 obo:IAO_0000115 "An abnormally increased number of plasma cells in tissues, exudates, or blood" ; oboInOwl:hasDbXref "UMLS:C0549295" ; a owl:Class ; rdfs:comment "A plasma cells (also known as plasma B cell, plasmocyte, or effector B cell), is a short-lived antibody-producing cell derived from a B lymphocyte." ; rdfs:label "Plasmacytosis" ; rdfs:subClassOf obo:HP_0004332 . obo:HP_0030151 obo:IAO_0000115 "Inflammation of the biliary ductal system, affecting the intrahepatic or extrahepatic portions, or both." ; oboInOwl:hasDbXref "MSH:D002761", "SNOMEDCT_US:82403002", "UMLS:C0008311" ; oboInOwl:hasExactSynonym "Bile duct inflammation" ; a owl:Class ; rdfs:comment "Cholangitis is characterized by biliary epithelial damage with inflammatory cell infiltration. Some cholangitis is also associated with ductal and periductal fibrosis." ; rdfs:label "Cholangitis" ; rdfs:subClassOf obo:HP_0012440, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001173 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030152 obo:IAO_0100001 "HP:0100574" ; a owl:Class ; rdfs:label "obsolete Biliary tract neoplasm" ; owl:deprecated true . obo:HP_0030153 obo:IAO_0000115 "Cholangiocarcinoma is a primary cancer originating in the biliary epithelium i.e., the cholangiocytes, of the extrahepatic and intrahepatic biliary ducts. It is extremely invasive, develops rapidly, often metastasizes, and has a very poor prognosis. They are slow growing tumors which spread longitudinally along the bile ducts with neural, perineural and subepithelial extension." ; oboInOwl:hasDbXref "MSH:D018281", "NCIT:C3262", "SNOMEDCT_US:312104005", "SNOMEDCT_US:70179006", "UMLS:C0206698" ; oboInOwl:hasExactSynonym "Bile duct cancer" ; a owl:Class ; rdfs:label "Cholangiocarcinoma" ; rdfs:subClassOf obo:HP_0100574 . obo:HP_0030154 obo:IAO_0000115 "Rupture of the wall of the gallbladder." ; oboInOwl:hasDbXref "SNOMEDCT_US:25345001", "UMLS:C0156215" ; oboInOwl:hasExactSynonym "Gall bladder perforation" ; a owl:Class ; rdfs:comment "Clinical presentation of a ruptured gallbladder can range from an acute generalised peritonitis to benign non-specific abdominal symptom. Gallbladder perforation is a rare but life-threatening complication of acute cholecystitis, with a reported mortality rate of 12 to 42 percent. The bile leak from a ruptured gallbladder might be contained in the extra peritoneal gallbladder fossa, and hence might not produce symptoms of peritonitis immediately." ; rdfs:label "Gallbladder perforation" ; rdfs:subClassOf obo:HP_0012437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030155 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:20502007", "UMLS:C0236078" ; oboInOwl:hasExactSynonym "Scrotal pain" ; a owl:Class ; rdfs:label "Scrotal pain" ; rdfs:subClassOf obo:HP_0000045, obo:HP_0012531 . obo:HP_0030156 obo:IAO_0000115 "The presence of free monoclonal immunoglobulin light chains in the urine." ; oboInOwl:hasDbXref "SNOMEDCT_US:274771005", "UMLS:C0004968" ; a owl:Class ; rdfs:comment "Bence Jones proteins are produced by neoplastic plasma cells and can be found in the context of multiple myeloma or Waldenstrom's macroglobulinemia." ; rdfs:label "Bence Jones Proteinuria" ; rdfs:subClassOf obo:HP_0020129 . obo:HP_0030157 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank." ; oboInOwl:hasBroadSynonym "Kidney pain" ; oboInOwl:hasDbXref "MSH:D021501", "SNOMEDCT_US:247355005", "UMLS:C0016199" ; oboInOwl:hasExactSynonym "Flank pain" ; a owl:Class ; rdfs:comment "The flank is the area on the side of the abdomen between the ribs and the hip." ; rdfs:label "Flank pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0030158 obo:IAO_0000115 "Cervical ectropion occurs when eversion of the endocervix exposes columnar epithelium to the vaginal milieu" ; oboInOwl:hasDbXref "MSH:D002579", "SNOMEDCT_US:61253004", "SNOMEDCT_US:79342006", "UMLS:C0007869", "UMLS:C0269189" ; oboInOwl:hasExactSynonym "Cervical ectopy" ; oboInOwl:hasRelatedSynonym "Cervical erosion" ; a owl:Class ; rdfs:comment "The upper cervix (endocervix) is lined by a simple columnar epithelium that contains mucous-secreting cells. In contrast, the lower cervix (ectocervix) is lined by a stratified squamous epithelium. The transition point between these two epithelia is known as the external os. Cervical ectropion is the presence of columnar cells on the ectocervix, which is normally composed of a squamous epithelium. Potential causes of ectropion include adolescent age, pregnancy, and hormonal contraceptives.5 Some clinicians believe ectropion could be a normal asymptomatic variant, whereas others believe it to be correlated with chronic cervicitis.5 The presence of the metaplastic columnar epithelium can manifest a myriad of symptoms including increased vaginal discharge, leukorrhea, postcoital bleeding, pelvic pain, recurrent cervicitis, and dyspareunia." ; rdfs:label "Cervical ectropion" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0030159 obo:IAO_0000115 "Abnormal growth of tissue projecting from a mucous membrane of the endocervix." ; oboInOwl:hasDbXref "MSH:D002583", "SNOMEDCT_US:123841004", "SNOMEDCT_US:65576009", "UMLS:C0007855", "UMLS:C0007873" ; oboInOwl:hasExactSynonym "Cervical tumor", "Cervical tumour" ; a owl:Class ; rdfs:label "Cervical polyp" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0030160 obo:IAO_0000115 "Inflammation of the uterine cervix." ; oboInOwl:hasDbXref "MSH:D002575", "SNOMEDCT_US:37610005", "UMLS:C0007860" ; oboInOwl:hasExactSynonym "Uterine cervicitis", "Uterine cervix inflammation" ; a owl:Class ; rdfs:comment "Cervicitis, which most commonly presents as vaginal discharge or postcoital bleeding, can be acute or chronic, with an infectious or noninfectious etiology." ; rdfs:label "Cervicitis" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0030161 obo:IAO_0000115 "A sensation of itching in the vagina." ; oboInOwl:hasDbXref "SNOMEDCT_US:34363003", "UMLS:C0042256" ; a owl:Class ; rdfs:label "Vaginal pruritus" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0000989 . obo:HP_0030162 obo:IAO_0000115 "Abnormally large size of glomeruli." ; oboInOwl:hasDbXref "UMLS:C4022604" ; a owl:Class ; rdfs:comment "Glomerulomegaly is a histologic finding that can be present in idiopathic pulmonary hypertension, congenital cyanotic heart disease, morbid obesity associated with sleep apnea syndrome, sickle cell disease, and polycythemic states." ; rdfs:label "Glomerulomegaly" ; rdfs:subClassOf obo:HP_0000095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030163 obo:IAO_0000115 "Abnormality of vascular function." ; oboInOwl:hasDbXref "UMLS:C4022603" ; a owl:Class ; rdfs:label "Abnormal vascular physiology" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0011025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007798 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030164 obo:IAO_0000115 "Pain in the jaw or ear induced by chewing or otherwise moving the jaw." ; oboInOwl:hasDbXref "SNOMEDCT_US:43922008", "UMLS:C0239064" ; oboInOwl:hasExactSynonym "Jaw pain while chewing" ; a owl:Class ; rdfs:label "Jaw claudication" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0030165 obo:IAO_0000115 "The presence of an increased number of twists and turns of the temporal artery." ; oboInOwl:hasDbXref "UMLS:C4022602" ; a owl:Class ; rdfs:label "Temporal artery tortuosity" ; rdfs:subClassOf obo:HP_0005116 . obo:HP_0030166 obo:IAO_0000115 "Occurrence of excessive sweating during sleep." ; oboInOwl:hasDbXref "SNOMEDCT_US:42984000", "UMLS:C0028081" ; oboInOwl:hasExactSynonym "Night sweats", "Nocturnal hyperhidrosis" ; a owl:Class ; rdfs:comment "Nighttime sweating is a symptom linked to menopause, malignancies, autoimmune diseases, and infections." ; rdfs:label "Night sweats" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0030167 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against mitochondria." ; oboInOwl:hasDbXref "UMLS:C4021051" ; oboInOwl:hasExactSynonym "Serum antimitochrondrial antibodies" ; a owl:Class ; rdfs:label "Antimitochondrial antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030168 obo:IAO_0000115 "Increase in diameter of the veins located underneath the skin of the abdomen." ; oboInOwl:hasDbXref "UMLS:C4021050" ; oboInOwl:hasExactSynonym "Dilatation of the superficial abdominal veins" ; a owl:Class ; rdfs:comment "There are two major causes of dilated superficial abdominal veins: (i) Liver cirrhosis and (ii) vena cava obstruction. With cirrhosis, the blood in the veins flows from umbilicus to periphery." ; rdfs:label "Dilated superficial abdominal veins" ; rdfs:subClassOf obo:HP_0001015 . obo:HP_0030169 obo:IAO_0000115 "Extreme dilation of the submucusoal veins in the stomach." ; oboInOwl:hasDbXref "MSH:D004932", "SNOMEDCT_US:91109007", "UMLS:C0017145" ; oboInOwl:hasRelatedSynonym "Gastric varices" ; a owl:Class ; rdfs:label "Gastric varix" ; rdfs:subClassOf obo:HP_0002577 . obo:HP_0030170 obo:IAO_0000115 "Presence of a pseudoaneurysm in the artery that supplies the gallbladder and cystic duct with blood. A pseudoaneurysm, also known as a false aneurysm, forms when blood leaks through a breach of the arterial wall but is contained by the adventitia or surrounding perivascular soft tissue." ; oboInOwl:hasDbXref "UMLS:C4022601" ; a owl:Class ; rdfs:label "Cystic artery pseudoaneurysm" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0030171 obo:IAO_0000115 "A collection of clotted blood surrounding the kidney." ; oboInOwl:hasDbXref "SNOMEDCT_US:197824007", "UMLS:C0473124" ; a owl:Class ; rdfs:comment "The causes of a spontaneous perirenal hematoma (SPH) include immunologic disorders, neoplasms (renal cell carcinomas and adenomas), and collagen vascular diseases, but the main cause of a secondary perirenal hematoma is traumatic injury." ; rdfs:label "Perirenal hematoma" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0030172 obo:IAO_0000115 "Congenital absence of the myelin sheath on a nerve." ; oboInOwl:hasDbXref "UMLS:C4022600" ; a owl:Class ; rdfs:label "Peripheral amyelination" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0022011 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030173 obo:IAO_0000115 "Increased amount of peripheral myelination." ; oboInOwl:hasDbXref "UMLS:C4021049" ; oboInOwl:hasExactSynonym "Increased peripheral myelination" ; a owl:Class ; rdfs:label "Peripheral hypermyelination" ; rdfs:subClassOf obo:HP_0003130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000345 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030174 obo:IAO_0000115 "Elevated thickness of the myelin sheath of peripheral nerves, in a regular and concentric fashion." ; oboInOwl:hasDbXref "UMLS:C4022599" ; a owl:Class ; rdfs:label "Increased peripheral myelin thickness" ; rdfs:subClassOf obo:HP_0030173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000347 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001021 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030175 obo:IAO_0000115 "The presence of multiple sausage-shaped swellings of the myelin sheath (The Latin tomaculum means sausage)." ; oboInOwl:hasDbXref "UMLS:C4020904" ; oboInOwl:hasExactSynonym "Tomacula" ; a owl:Class ; rdfs:comment "Several mechanisms that may lead to the formation of a tomaculum-for example, hypermyelination, redundant loop formation, the presence of a second mesaxon, transnodal myelination, two Schwann cells forming one myelin sheath, and disruption of the myelin sheath. Sural nerve biopsies typically show regions of myelin thickening as well as features of demyelination and remyelination." ; rdfs:label "Myelin tomacula" ; rdfs:subClassOf obo:HP_0030173 . obo:HP_0030176 obo:IAO_0000115 "Loss of myelin from peripheral nerves in a pattern that differs between right and left." ; oboInOwl:hasDbXref "UMLS:C4022598" ; a owl:Class ; rdfs:comment "This feature may be observed in hereditary neuropathy with liability to pressure palsies, but also in acquired inflammatory neuropathies." ; rdfs:label "Asymmetric peripheral demyelination" ; rdfs:subClassOf obo:HP_0011096 . obo:HP_0030177 obo:IAO_0000115 "An abnormality of the function of the electrical signals with which peripheral nerve cells communicate with each other or with muscles." ; oboInOwl:hasDbXref "UMLS:C0853150" ; oboInOwl:hasExactSynonym "Abnormal nerve conduction study" ; a owl:Class ; rdfs:label "Abnormality of peripheral nervous system electrophysiology" ; rdfs:subClassOf obo:HP_0001311, obo:HP_0032120 . obo:HP_0030178 oboInOwl:hasDbXref "UMLS:C4022597" ; oboInOwl:hasExactSynonym "Abnormality of CNS electrophysiology" ; a owl:Class ; rdfs:label "Abnormality of central nervous system electrophysiology" ; rdfs:subClassOf obo:HP_0001311 . obo:HP_0030179 obo:IAO_0000115 "An anomaly in the magnitude of the action potential along a peripheral nerve, that is, of the rapid rise and fall of the electrical membrane potential of the nerve." ; oboInOwl:hasDbXref "UMLS:C4022596" ; a owl:Class ; rdfs:label "Abnormal peripheral action potential amplitude" ; rdfs:subClassOf obo:HP_0003134 . obo:HP_0030180 obo:IAO_0000115 "Dorsiflexion of the big toe, sometimes accompanied by fanning of the other toes, elicited by stroking along the medial side of the tibia (the normal response would be no movement of the big toe)." ; oboInOwl:hasDbXref "SNOMEDCT_US:414949005", "UMLS:C1532837" ; oboInOwl:hasExactSynonym "Oppenheim sign" ; a owl:Class ; rdfs:comment "This reflex can indicate affection of the corticospinal (pyramidal) tracts." ; rdfs:label "Oppenheim reflex" ; rdfs:subClassOf obo:HP_0007256 . obo:HP_0030181 obo:IAO_0000115 "Dorsal extension of the big toe, sometimes accompanied by fanning of the other toes, elicited by compressing the calf muscles (a normal response is no movement of the big toe)." ; oboInOwl:hasDbXref "UMLS:C4021048" ; oboInOwl:hasExactSynonym "Gordon sign" ; a owl:Class ; rdfs:comment "Gordon's reflex indicates a lesion of the pyramidal tract." ; rdfs:label "Gordon reflex" ; rdfs:subClassOf obo:HP_0007256 . obo:HP_0030182 obo:IAO_0000115 "Loss of strength in all four limbs. Tetraplegia refers to a complete loss of strength, whereas Tetraparesis refers to an incomplete loss of strength." ; oboInOwl:hasDbXref "UMLS:C4022595" ; a owl:Class ; rdfs:label "Tetraplegia/tetraparesis" ; rdfs:subClassOf obo:HP_0010549 . obo:HP_0030183 obo:IAO_0000115 "The vestibulo-ocular reflex is responsible for the stabilization of the retinal image during movement. The visual vestibular ocular reflex (VVOR) or visual enhanced VOR, maintains ocular stability during head motion by generating compensatory eye movement opposite to head movement, and is a major component of visual vestibular interaction. This feature is an impairment of this reflex, manifested as the combined impairment of the three compensatory eye movement reflexes, namely the vestibulo-ocular reflex (VOR), smooth pursuit (SP) and optokinetic reflex (OKR)." ; oboInOwl:hasDbXref "UMLS:C4021047" ; oboInOwl:hasExactSynonym "VVOR impairment", "Visually enhanced vestibulo-ocular reflex impairment" ; a owl:Class ; rdfs:label "Impaired visually enhanced vestibulo-ocular reflex" ; rdfs:subClassOf obo:HP_0007670 . obo:HP_0030185 obo:IAO_0000115 "An isometric tremor occurs with muscle contraction against a rigid stationary object (e.g., when making a fist)." ; oboInOwl:hasDbXref "UMLS:C4022594", "UMLS:C4280303" ; oboInOwl:hasRelatedSynonym "Dystonia tremor" ; a owl:Class ; rdfs:label "Isometric tremor" ; rdfs:subClassOf obo:HP_0002345 . obo:HP_0030186 obo:IAO_0000115 "Tremor that occurs during any voluntary movement. It may include visually or non-visually guided movements. Tremor during target directed movement is called intention tremor." ; oboInOwl:hasDbXref "MSH:D014202", "MSH:D020329", "SNOMEDCT_US:30721006", "SNOMEDCT_US:609558009", "UMLS:C0234376", "UMLS:C0270736" ; oboInOwl:hasExactSynonym "Essential tremor" ; a owl:Class ; rdfs:label "Kinetic tremor" ; rdfs:subClassOf obo:HP_0002345 . obo:HP_0030187 obo:IAO_0000115 "Nodding movement of the head or body." ; oboInOwl:hasDbXref "SNOMEDCT_US:78691002", "UMLS:C0231690" ; a owl:Class ; rdfs:label "Titubation" ; rdfs:subClassOf obo:HP_0002345 . obo:HP_0030188 obo:IAO_0000115 "Tremor classified by the affected body part." ; oboInOwl:hasDbXref "UMLS:C4022593" ; oboInOwl:hasExactSynonym "Tremor of a body part" ; a owl:Class ; rdfs:label "Tremor by anatomical site" ; rdfs:subClassOf obo:HP_0001337 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001062 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030190 obo:IAO_0000115 "Reduced muscle tone of oral musculature. In infants, this feature may be associated with difficulties in breast feeding, and may affect the latch, jaw motions, tongue placement, lip seal, suck/swallow/breathe pattern and overall feeding behavior." ; oboInOwl:hasDbXref "UMLS:C4022592" ; a owl:Class ; rdfs:label "Oral motor hypotonia" ; rdfs:subClassOf obo:HP_0001252 . obo:HP_0030191 obo:IAO_0000115 "An anomaly in the communication from a neuron to a target across a synapse in the peripheral nervous system." ; oboInOwl:hasDbXref "UMLS:C4021046" ; oboInOwl:hasExactSynonym "Abnormal PNS synaptic transmission" ; a owl:Class ; rdfs:label "Abnormal peripheral nervous system synaptic transmission" ; rdfs:subClassOf obo:HP_0012535 . obo:HP_0030192 obo:IAO_0000115 "A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022591" ; a owl:Class ; rdfs:label "Fatigable weakness of bulbar muscles" ; rdfs:subClassOf obo:HP_0003473 . obo:HP_0030193 obo:IAO_0000115 "A type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022590" ; a owl:Class ; rdfs:label "Fatigable weakness of chewing muscles" ; rdfs:subClassOf obo:HP_0030192 . obo:HP_0030194 obo:IAO_0000115 "A type of weakness of the muscles involved in speech that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022589" ; a owl:Class ; rdfs:label "Fatigable weakness of speech muscles" ; rdfs:subClassOf obo:HP_0030192 . obo:HP_0030195 obo:IAO_0000115 "A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022588" ; a owl:Class ; rdfs:label "Fatigable weakness of swallowing muscles" ; rdfs:subClassOf obo:HP_0030192 . obo:HP_0030196 obo:IAO_0000115 "A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022587" ; a owl:Class ; rdfs:label "Fatigable weakness of respiratory muscles" ; rdfs:subClassOf obo:HP_0003473 . obo:HP_0030197 obo:IAO_0000115 "A type of weakness of skeletal muscle that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022586" ; a owl:Class ; rdfs:label "Fatigable weakness of skeletal muscles" ; rdfs:subClassOf obo:HP_0003473 . obo:HP_0030198 obo:IAO_0000115 "A type of weakness of a skeletal muscle of distal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022585" ; a owl:Class ; rdfs:label "Fatigable weakness of distal limb muscles" ; rdfs:subClassOf obo:HP_0030197 . obo:HP_0030199 obo:IAO_0000115 "A type of weakness of a skeletal muscle in the neck that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022584" ; a owl:Class ; rdfs:label "Fatigable weakness of neck muscles" ; rdfs:subClassOf obo:HP_0030197 . obo:HP_0030200 obo:IAO_0000115 "A type of weakness of a skeletal muscle of proximal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." ; oboInOwl:hasDbXref "UMLS:C4022583" ; a owl:Class ; rdfs:label "Fatiguable weakness of proximal limb muscles" ; rdfs:subClassOf obo:HP_0030197 . obo:HP_0030201 obo:IAO_0000115 "Specific drugs interfere selectively with the different cellular mechanisms involved in neuromuscular transmission (synthesis, storage, release, action and inactivation of transmitter). The response of a patient to a specific drug can therefore be useful information for the differential diagnosis." ; oboInOwl:hasDbXref "UMLS:C4022582" ; a owl:Class ; rdfs:label "Response to drugs acting on neuromuscular transmission" ; rdfs:subClassOf obo:HP_0030191 . obo:HP_0030202 obo:IAO_0000115 "Improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor." ; oboInOwl:hasDbXref "UMLS:C4022581" ; oboInOwl:hasExactSynonym "Favourable response of weakness to acetylcholine esterase inhibitors" ; a owl:Class ; rdfs:comment "An acetylcholinesterase inhibitor inhibits acetylcholinesterase from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. For instance, edrophonium is a readily reversible acetylcholinesterase inhibitor that can be used to differentiate myasthenia gravis from cholinergic crisis. Edrophonium would improve muscle weakness in myasthenia gravis but not in cholinergic crisis." ; rdfs:label "Favorable response of weakness to acetylcholine esterase inhibitors" ; rdfs:subClassOf obo:HP_0030201 . obo:HP_0030203 obo:IAO_0000115 "Lack of improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor." ; oboInOwl:hasDbXref "UMLS:C4022580" ; oboInOwl:hasExactSynonym "Unfavourable response of muscle weakness to acetylcholine esterase inhibitors" ; a owl:Class ; rdfs:comment "An acetylcholinesterase inhibitor inhibits acetylcholinesterase from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. For instance, edrophonium is a readily reversible acetylcholinesterase inhibitor that can be used to differentiate myasthenia gravis from cholinergic crisis. Edrophonium would improve muscle weakness in myasthenia gravis but not in cholinergic crisis." ; rdfs:label "Unfavorable response of muscle weakness to acetylcholine esterase inhibitors" ; rdfs:subClassOf obo:HP_0030201 . obo:HP_0030205 obo:IAO_0000115 "The variation in the time interval between the two action potentials of the same motor unit is called jitter. This term therefore applies to increased variability in the interval between successive action potentials of the same motor unit, which is measured by electromyography (EMG)." ; oboInOwl:hasDbXref "UMLS:C4021045" ; oboInOwl:hasExactSynonym "Increased jitter at single fibre EMG", "Increased jitter at single fibre electromyography" ; a owl:Class ; rdfs:comment "Increased jitter values are not pathogonomic for myasthenia, but indicate disturbed neuromuscular transmission." ; rdfs:label "Increased jitter at single fiber EMG" ; rdfs:subClassOf obo:HP_0030006 . obo:HP_0030206 obo:IAO_0000115 "A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to an abnormal increase in the amplitude during the course of the investigation." ; oboInOwl:hasDbXref "UMLS:C4022579" ; a owl:Class ; rdfs:comment "This feature may be observed with Lambert-Eaton Myasthenic Ssyndrome." ; rdfs:label "EMG: incremental response of compound muscle action potential to repetitive nerve stimulation" ; rdfs:subClassOf obo:HP_0100285 . obo:HP_0030207 obo:IAO_0000115 "Breathing movements in which the chest wall moves in on inspiration and out on expiration, in reverse of the normal movements. It may be seen in children with respiratory distress of any cause, which leads to indrawing of the intercostal spaces during inspiration. Patients with chronic airways obstruction also show indrawing of the lower ribs during inspiration, due to the distorted action of a depressed and flattened diaphragm. Crush injuries of the chest, with fractured ribs and sternum, can lead to a severe degree of paradoxical breathing." ; oboInOwl:hasDbXref "MSH:D005409", "SNOMEDCT_US:12025005", "SNOMEDCT_US:78011002", "UMLS:C0016196", "UMLS:C0231852" ; oboInOwl:hasExactSynonym "Paradoxical breathing" ; oboInOwl:hasRelatedSynonym "Flail chest" ; a owl:Class ; rdfs:label "Paradoxical respiration" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0030208 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ganglioside-monosialic acid (GM1), which is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury." ; oboInOwl:hasDbXref "UMLS:C4022578" ; oboInOwl:hasExactSynonym "Acetylcholine receptor antibody positivity", "Anti-AChR antibody positivity" ; a owl:Class ; rdfs:label "Anti-acetylcholine receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030209 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against voltage-gated calcium channels." ; oboInOwl:hasDbXref "UMLS:C4022577" ; oboInOwl:hasExactSynonym "Ca channel antibody positivity", "Ca2+ channel antibody positivity" ; a owl:Class ; rdfs:comment "This abnormality can be observed in patients with Lambert-Eaton syndrome and other paraneoplastic syndromes." ; rdfs:label "Calcium channel antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030210 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against muscle specific kinase (anti-MuSK Ab)." ; oboInOwl:hasAlternativeId "HP:5000045" ; oboInOwl:hasDbXref "UMLS:C4021044" ; oboInOwl:hasExactSynonym "Anti-MUSK antibodies", "Anti-muscle-specific tyrosine kinase antibody", "Muscle specific kinase antibody positivity" ; a owl:Class ; rdfs:label "Anti-muscle-specific tyrosine kinase antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030211 obo:IAO_0000115 "Reduced velocity and acceleration in the pupillary light response." ; oboInOwl:hasDbXref "UMLS:C4022576" ; oboInOwl:hasExactSynonym "Sluggish pupillary reaction" ; a owl:Class ; rdfs:label "Slow pupillary light response" ; rdfs:subClassOf obo:HP_0007695 . obo:HP_0030212 obo:IAO_0000115 "Excessive or pathological tendency to save and collect possessions." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:247968005", "UMLS:C0424290" ; oboInOwl:hasExactSynonym "Collecting", "Compulsive hoarding", "Hoarding" ; a owl:Class ; rdfs:label "Collectionism" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_0030213 obo:IAO_0000115 "Lack of emotional reactivity and empathy for situations or persons, sometime also for family members." ; oboInOwl:hasDbXref "SNOMEDCT_US:6140007", "UMLS:C0233469" ; a owl:Class ; rdfs:label "Emotional blunting" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0030214 obo:IAO_0000115 "Pathological persistent sexual disinhibiting behavior, directed at oneself or to others." ; oboInOwl:hasDbXref "SNOMEDCT_US:73744004", "UMLS:C0312420", "UMLS:C0679145" ; oboInOwl:hasExactSynonym "Sex addiction" ; a owl:Class ; rdfs:label "Hypersexuality" ; rdfs:subClassOf obo:HP_0008768 . obo:HP_0030215 obo:IAO_0000115 "Uncontrolled episodes of crying, without apparent motivating stimuli." ; oboInOwl:hasDbXref "UMLS:C0860609" ; oboInOwl:hasExactSynonym "Inappropriate crying" ; a owl:Class ; rdfs:label "Inappropriate crying" ; rdfs:subClassOf obo:HP_0000719 . obo:HP_0030216 obo:IAO_0000115 "Reduction of goal-directed behaviors linked to the impairment in frontal executive functions (planning of an action for example)." ; oboInOwl:hasDbXref "UMLS:C4022575" ; a owl:Class ; rdfs:label "Inertia" ; rdfs:subClassOf obo:HP_0000745 . obo:HP_0030217 obo:IAO_0000115 "Difficulty in performing the correct execution of limbs movements in absence of motor impairment." ; oboInOwl:hasDbXref "UMLS:C4022574" ; a owl:Class ; rdfs:label "Limb apraxia" ; rdfs:subClassOf obo:HP_0002186 . obo:HP_0030218 obo:IAO_0000115 "Punding is a stereotypical motor behavior characterized by an intense fascination with repetitive, excessive and non-goal oriented handling, and examining of objects." ; oboInOwl:hasDbXref "UMLS:C1963933" ; a owl:Class ; rdfs:label "Punding" ; rdfs:subClassOf obo:HP_0000733 . obo:HP_0030219 obo:IAO_0000115 "A progressive loss of the ability to remember the meaning of words, faces and objects." ; oboInOwl:hasDbXref "MSH:D057180", "SNOMEDCT_US:230288001", "UMLS:C0338462" ; oboInOwl:hasRelatedSynonym "Trouble remembering words" ; a owl:Class ; rdfs:label "Semantic dementia" ; rdfs:subClassOf obo:HP_0002145 . obo:HP_0030220 obo:IAO_0000115 "Behavior that is not in line with social norms." ; oboInOwl:hasDbXref "UMLS:C2220010" ; oboInOwl:hasExactSynonym "Socially inappropriate behavior", "Socially inappropriate behaviour" ; a owl:Class ; rdfs:label "Socially inappropriate behavior" ; rdfs:subClassOf obo:HP_0000719 . obo:HP_0030221 obo:IAO_0000115 "Excessive desire to eat sweet foods." ; oboInOwl:hasDbXref "UMLS:C0241314" ; oboInOwl:hasExactSynonym "Sweet craving" ; a owl:Class ; rdfs:label "Sweet craving" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0030222 obo:IAO_0000115 "Difficulty in recognizing objects by visual input in absence of sensorial visual impairment." ; oboInOwl:hasDbXref "MSH:D000377", "SNOMEDCT_US:25762009", "UMLS:C0234502" ; a owl:Class ; rdfs:label "Visual agnosia" ; rdfs:subClassOf obo:HP_0010524 . obo:HP_0030223 obo:IAO_0000115 "Manifestations of perseverative thoughts are behaviors that do not meet the demands of the situation, are not the product of deliberation, and may unfold despite counter intention." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "SNOMEDCT_US:44515000", "UMLS:C0233651" ; oboInOwl:hasExactSynonym "Perseveration", "Perseverative behavior", "Perseverative behaviour" ; a owl:Class ; rdfs:label "Manifestations of perseverative thought or action" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0030224 obo:IAO_0000115 "A deviation from normal in the expression of desmin in muscle tissue. Desmin is an 53-kDa protein." ; oboInOwl:hasDbXref "UMLS:C4022573" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre desmin" ; a owl:Class ; rdfs:label "Abnormal muscle fiber desmin" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030225 obo:IAO_0000115 "Immunohistochemistry shows accumulation of desmin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4021043" ; oboInOwl:hasExactSynonym "Accumulation of muscle fibre desmin", "Muscle fiber desmin-reactive inclusion bodies", "Muscle fibre desmin-reactive inclusion bodies" ; a owl:Class ; rdfs:label "Accumulation of muscle fiber desmin" ; rdfs:subClassOf obo:HP_0030224 . obo:HP_0030226 obo:IAO_0000115 "A deviation from normal in the expression of myotilin in muscle tissue. Myotilin is a 57kDa cytoskeletal protein." ; oboInOwl:hasDbXref "UMLS:C4022572" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre myotilin" ; a owl:Class ; rdfs:label "Abnormal muscle fiber myotilin" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030227 obo:IAO_0000115 "Immunohistochemistry shows accumulation of myotilin protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022571" ; oboInOwl:hasExactSynonym "Accumulation of muscle fibre myotilin" ; a owl:Class ; rdfs:label "Accumulation of muscle fiber myotilin" ; rdfs:subClassOf obo:HP_0030226 . obo:HP_0030228 obo:IAO_0000115 "A deviation from normal in the expression of valosin-containing protein in muscle tissue. Valosin-containing protein is an ubiquitously expressed multifunctional 100-kD protein that is a member of the AAA+ (ATPase associated with various activities) protein family." ; oboInOwl:hasDbXref "UMLS:C4022570" ; oboInOwl:hasExactSynonym "Abnormal muscle fibre valosin-containing protein" ; a owl:Class ; rdfs:label "Abnormal muscle fiber valosin-containing protein" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0030229 obo:IAO_0000115 "Immunohistochemistry shows accumulation of valosin-containing protein in the muscle biopsy." ; oboInOwl:hasDbXref "UMLS:C4022569" ; oboInOwl:hasExactSynonym "Accumulation of muscle fibre valosin-containing protein" ; a owl:Class ; rdfs:label "Accumulation of muscle fiber valosin-containing protein" ; rdfs:subClassOf obo:HP_0030228 . obo:HP_0030230 obo:IAO_0000115 "The presence of disorganized areas called cores in the center of muscle fibers. There is a typical appearance of the biopsy on light microscopy, where the muscle cells have cores that are devoid of mitochondria and specific enzymes. Cores are typically well demarcated and centrally located, but may occasionally be multiple and of eccentric." ; oboInOwl:hasDbXref "UMLS:C4022568" ; oboInOwl:hasExactSynonym "Central core regions in muscle fibres" ; a owl:Class ; rdfs:label "Central core regions in muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0030231 obo:IAO_0000115 "An increased amount of glycogen in muscle tissue found specifically in lysosomes." ; oboInOwl:hasDbXref "UMLS:C4022567" ; oboInOwl:hasExactSynonym "Glycogen accumulation in muscle fibre lysosomes" ; a owl:Class ; rdfs:label "Glycogen accumulation in muscle fiber lysosomes" ; rdfs:subClassOf obo:HP_0009051 . obo:HP_0030232 obo:IAO_0000115 "Elevated glycogen content in the sarcoplasm (cytoplasm) of muscle fibers." ; oboInOwl:hasDbXref "UMLS:C4022566" ; a owl:Class ; rdfs:label "Increased sarcoplasmic glycogen" ; rdfs:subClassOf obo:HP_0009051 . obo:HP_0030233 obo:IAO_0000115 "Limitation of wrist and finger extension on asking patient to form a prayer sign. This is a result of progressive wrist and finger flexion contractures." ; oboInOwl:hasDbXref "UMLS:C4021042" ; oboInOwl:hasExactSynonym "Bethlem phenomenon" ; a owl:Class ; rdfs:label "Bethlem sign" ; rdfs:subClassOf obo:HP_0009473 . obo:HP_0030234 obo:IAO_0000115 "An increased CPK level between 4X and 50X above the upper normal level." ; oboInOwl:hasDbXref "UMLS:C4022565" ; oboInOwl:hasExactSynonym "Highly elevated CPK", "Highly elevated creatine phosphokinase", "Highly elevated serum CK", "Highly elevated serum CPK", "Highly elevated serum phosph-CK" ; a owl:Class ; rdfs:label "Highly elevated creatine kinase" ; rdfs:subClassOf obo:HP_0003236 . obo:HP_0030235 obo:IAO_0000115 "An increased creatine kinase level more than 50X above the upper normal level." ; oboInOwl:hasDbXref "UMLS:C4022564" ; oboInOwl:hasExactSynonym "Extremely elevated CPK", "Extremely elevated creatine phosphokinase", "Extremely elevated phospho-CK serum level", "Extremely elevated serum CK level", "Extremely high CPK level" ; a owl:Class ; rdfs:label "Extremely elevated creatine kinase" ; rdfs:subClassOf obo:HP_0003236 . obo:HP_0030236 obo:IAO_0000115 "Abnormalities of the overall muscle bulk based on clinical observation." ; oboInOwl:hasDbXref "UMLS:C4022563" ; oboInOwl:hasExactSynonym "Abnormality of muscle size" ; a owl:Class ; rdfs:label "Abnormality of muscle size" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0030237 obo:IAO_0000115 "Reduced strength of the musculature of the hand." ; oboInOwl:hasDbXref "SNOMEDCT_US:298283006", "UMLS:C0239831" ; oboInOwl:hasExactSynonym "Hand muscle weakness" ; a owl:Class ; rdfs:label "Hand muscle weakness" ; rdfs:subClassOf obo:HP_0001421 . obo:HP_0030239 obo:IAO_0000115 "Underdevelopment of the musculature of the upper arm, which may include the deltoid, the triceps, the biceps, and the brachioradialis." ; oboInOwl:hasDbXref "UMLS:C4022562" ; oboInOwl:hasExactSynonym "Underdeveloped upper arm muscles" ; a owl:Class ; rdfs:label "Hypoplasia of the upper arm musculature" ; rdfs:subClassOf obo:HP_0009016 . obo:HP_0030241 obo:IAO_0000115 "Underdevelopment of the deltoid muscle." ; oboInOwl:hasAlternativeId "HP:0009039", "HP:0009044" ; oboInOwl:hasDbXref "UMLS:C1868170" ; oboInOwl:hasExactSynonym "Deltoid muscle hypoplasia" ; a owl:Class ; rdfs:label "Hypoplasia of deltoid muscle" ; rdfs:subClassOf obo:HP_0008952 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030242 obo:IAO_0000115 "Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the superior and inferior mesenteric veins." ; oboInOwl:hasDbXref "SNOMEDCT_US:17920008", "UMLS:C0155773" ; oboInOwl:hasExactSynonym "Blood clot in portal vein" ; a owl:Class ; rdfs:comment "Portal vein thrombosis (PVT) can occur within the main portal vein, or it can occur in the branches of the portal vein within the liver itself. It can be an occluding thrombus or nonoccluding, with a clot present but continued blood flow through the vessel. The sequela of a long-standing PVT is cavernous formation of the portal vein, which represents bridging collaterals around the occlusion." ; rdfs:label "Portal vein thrombosis" ; rdfs:subClassOf obo:HP_0030247, obo:HP_0031941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030243 obo:IAO_0000115 "An obstruction in the veins of the liver caused by a blood clot (thrombosis)." ; oboInOwl:hasDbXref "MSH:D006502", "SNOMEDCT_US:38739001", "UMLS:C0019154" ; oboInOwl:hasExactSynonym "Blood clot in liver vein", "Hepatic venous thrombosis" ; a owl:Class ; rdfs:label "Hepatic vein thrombosis" ; rdfs:subClassOf obo:HP_0030247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001977 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001143 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030244 obo:IAO_0000115 "The occurence of an elevated body temperature of the mother during pregnancy." ; oboInOwl:hasDbXref "UMLS:C4021041" ; oboInOwl:hasExactSynonym "Maternal fever during pregnancy" ; a owl:Class ; rdfs:comment "There is evidence to suugest that maternal fever during pregnancy may negatively affect offspring healthneural tube defects, congenital heart defects, and oral clefts, in which meta-analyses suggested between a 1.5- and nearly 3-fold increased risk with fever exposure in the first trimester." ; rdfs:label "Maternal fever in pregnancy" ; rdfs:subClassOf obo:HP_0001945, obo:HP_0002686 . obo:HP_0030245 obo:IAO_0000115 "The occurence of maternal fever during labor." ; oboInOwl:hasDbXref "UMLS:C3829514" ; oboInOwl:hasExactSynonym "Maternal fever during labor", "Maternal fever during labour" ; a owl:Class ; rdfs:comment "Intrapartum fever may indicate chorioamnionitis. Intrapartum fever is an important predictor of neonatal morbidity and infection-related mortality." ; rdfs:label "Intrapartum fever" ; rdfs:subClassOf obo:HP_0030244 . obo:HP_0030246 obo:IAO_0000115 "The occurence of fever in a mother during the first trimester of pregnancy." ; oboInOwl:hasDbXref "UMLS:C4022561" ; a owl:Class ; rdfs:label "Maternal first trimester fever" ; rdfs:subClassOf obo:HP_0030244 . obo:HP_0030247 obo:IAO_0000115 "The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity)." ; oboInOwl:hasDbXref "UMLS:C4022560" ; oboInOwl:hasExactSynonym "Blood clot in splanchnic vein" ; a owl:Class ; rdfs:label "Splanchnic vein thrombosis" ; rdfs:subClassOf obo:HP_0004936 . obo:HP_0030248 obo:IAO_0000115 "A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine)." ; oboInOwl:hasDbXref "MSH:D065666", "SNOMEDCT_US:95446005", "UMLS:C0267412" ; oboInOwl:hasExactSynonym "Blood clot in mesentertic vein" ; a owl:Class ; rdfs:comment "Mesenteric venous thrombosis may be associated with abdominal pain and bloating, diarrhea, fever, gastrointestinal bleeding, and vomiting." ; rdfs:label "Mesenteric venous thrombosis" ; rdfs:subClassOf obo:HP_0030247 . obo:HP_0030249 obo:IAO_0000115 "A sudden eruption (rash) of the surface of a mucous membrane of the mouth or pharynx." ; oboInOwl:hasDbXref "SNOMEDCT_US:5862001", "UMLS:C0014034" ; a owl:Class ; rdfs:label "Enanthema" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0030250 obo:IAO_0000115 "The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the lung." ; oboInOwl:hasDbXref "UMLS:C0856628" ; a owl:Class ; rdfs:label "Pulmonary granulomatosis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0030251 obo:IAO_0000115 "Complete lack of memory B cells, that is, of mature B cell type that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin." ; oboInOwl:hasDbXref "UMLS:C4022559" ; a owl:Class ; rdfs:label "Absence of memory B cells" ; rdfs:subClassOf obo:HP_0010976 . obo:HP_0030252 obo:IAO_0000115 "Complete lack of mature B cells, that is, of B cells that have left the bone marrow." ; oboInOwl:hasDbXref "UMLS:C4022558" ; oboInOwl:hasExactSynonym "Absence of mature B cells" ; a owl:Class ; rdfs:label "Absent circulating B cells" ; rdfs:subClassOf obo:HP_0010976 . obo:HP_0030253 obo:IAO_0000115 "A reduced ability of a T cell population to expand by cell division following T cell activation." ; oboInOwl:hasDbXref "UMLS:C4022557" ; a owl:Class ; rdfs:label "Defective T cell proliferation" ; rdfs:subClassOf obo:HP_0005435, obo:HP_0031379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030254 obo:IAO_0000115 "Small areas of bleeding (hemorrhage) under the fingernail or toenail." ; oboInOwl:hasDbXref "UMLS:C0877087" ; oboInOwl:hasExactSynonym "Nail bed haemorrhage" ; a owl:Class ; rdfs:label "Nail bed hemorrhage" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0030255 obo:IAO_0000115 "The presence of multiple polyps in the large intestine." ; oboInOwl:hasDbXref "UMLS:C4022556" ; a owl:Class ; rdfs:label "Large intestinal polyposis" ; rdfs:subClassOf obo:HP_0200008 . obo:HP_0030256 obo:IAO_0000115 "The presence of multiple polyps in the small intestine." ; oboInOwl:hasDbXref "UMLS:C4022555" ; a owl:Class ; rdfs:label "Small intestinal polyposis" ; rdfs:subClassOf obo:HP_0200008 . obo:HP_0030257 obo:IAO_0000115 "One or more brown punctate macules on the skin of the genitalia." ; oboInOwl:hasDbXref "UMLS:C4021040" ; oboInOwl:hasExactSynonym "Freckled genitalia", "Genitalia, ephelides" ; a owl:Class ; rdfs:comment "This should be differentiated from Hyperpigmented genitalia in which an area larger than a freckle or the complete external genitalia are hyperpigmented. The description should be qualified by a description of the affected part(s)." ; rdfs:label "Freckled genitalia" ; rdfs:subClassOf obo:HP_0012293 . obo:HP_0030258 obo:IAO_0000115 "Localized or generalized increased genital pigmentation." ; oboInOwl:hasDbXref "UMLS:C4020713", "UMLS:C4022554" ; oboInOwl:hasExactSynonym "Increased genital pigmentation" ; oboInOwl:hasRelatedSynonym "Penile melanosis" ; a owl:Class ; rdfs:comment "This is an assessment of the relative pigmentation of the genitalia compared to the overall pigmentation of the individual. Hyperpigmentation can affect other parts of the body or be restricted to the genitalia. Genital hyperpigmentation can be generalized or localized. Localized areas of hyperpigmentation of the glans of the penis are especially common. This should be differentiated from Freckled genitalia in which one or more small, focal areas of hyperpigmentation are present. Localized hyperpigmentation can be objectively determined due to the difference from the immediate surrounding tissue color, while generalized hyperpigmentation may be more difficult to determine and is therefore a subjective manifestation. If the finding is localized, the description should be appended with a description of the affected part(s)." ; rdfs:label "Hyperpigmented genitalia" ; rdfs:subClassOf obo:HP_0012293 . obo:HP_0030259 obo:IAO_0000115 "Localized or generalized decreased genital pigmentation." ; oboInOwl:hasDbXref "UMLS:C4022553" ; oboInOwl:hasExactSynonym "Decreased genital pigmentation" ; a owl:Class ; rdfs:comment "This is an assessment of the relative pigmentation of the genitalia compared to the overall pigmentation of the individual. Hypopigmentation can affect other parts of the body or be restricted to the genitalia. Genital hypopigmentation can be generalized or localized. Localized hypopigmentation can be objectively determined due to the difference from the immediate surrounding tissue color, while generalized hypopigmentation may be more difficult to determine and is therefore a subjective manifestation." ; rdfs:label "Hypopigmented genitalia" ; rdfs:subClassOf obo:HP_0012293 . obo:HP_0030260 obo:IAO_0000115 "Length of penis more than 2 SD below the mean for age accompanied by hypospadias." ; oboInOwl:hasDbXref "SNOMEDCT_US:276333003", "UMLS:C0240701" ; a owl:Class ; rdfs:comment "Traditionally a distinction is made between a Short penis, a short penis with otherwise normal anatomy, versus microphallus, a short penis with hypospadias. Penile length is the distance between the midline attachment of the gently stretched, flaccid penis above the pubic symphysis and tip of the glans. A short penis should be differentiated from an inconspicuous penis, for instance due to excessive suprapubic fat (\"buried\"). We also recognize that shortness of a penis is defined by some subspecialists as penile length more than 2.5 SD below the mean." ; rdfs:label "Microphallus" ; rdfs:subClassOf obo:HP_0008736 . obo:HP_0030261 obo:IAO_0000115 "Lack of recognizable penile structures." ; oboInOwl:hasAlternativeId "HP:0040316" ; oboInOwl:hasDbXref "SNOMEDCT_US:204908001", "SNOMEDCT_US:59981001", "UMLS:C0555231" ; oboInOwl:hasExactSynonym "Absent penis", "Aphallia", "Aplasia of the penis", "Penis aplasia" ; a owl:Class ; rdfs:comment "Absence of the penis is always accompanied by abnormal position of the meatus (usually in the perineum, sometimes in the rectum), may be accompanied by Cryptorchidism, and is often associated with non-genital anomalies, which all should be coded separately. Absent penis should be differentiated from a penis concealed within pre-pubic fat tissue." ; rdfs:label "Absent penis" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030262 obo:IAO_0000115 "Penile width more than 2 standard deviations (SD) below the mean for age. Alternatively circumference of the flaccid penis more than 2 SD below the mean for age. Alternatively, apparently decreased penile width for age." ; oboInOwl:hasDbXref "UMLS:C4022552" ; oboInOwl:hasExactSynonym "Narrow penis" ; a owl:Class ; rdfs:comment "Penile width is the distance between left and right side of the flaccid penis at the attachment to the skin above the pubic symphysis." ; rdfs:label "Narrow penis" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030263 obo:IAO_0000115 "Rotated position of the glans, with or without the penile shaft, of 30 degrees or more." ; oboInOwl:hasDbXref "UMLS:C1407019" ; a owl:Class ; rdfs:comment "Penile torsion is defined traditionally as being between 30 and 180 degrees rotation. Penile torsion is usually counter clockwise and is often associated with Chordee and Hypospadias, which should be coded separately." ; rdfs:label "Torsion of the penis" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0030264 obo:IAO_0000115 "Ventral skinfold extending from penis to scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:253852007", "UMLS:C0431670" ; oboInOwl:hasExactSynonym "Webbed penis" ; a owl:Class ; rdfs:comment "The distal limit of the skinfold can be located on the penile shaft or the tip of the penis." ; rdfs:label "Webbed penis" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0030265 obo:IAO_0000115 "Distance between left and right side of the flaccid penis at the attachment to the skin above the pubic symphysis more than 2 standard deviations above the mean for age." ; oboInOwl:hasDbXref "UMLS:C4022551" ; oboInOwl:hasExactSynonym "Wide penis" ; a owl:Class ; rdfs:label "Wide penis" ; rdfs:subClassOf obo:HP_0030264 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030266 obo:IAO_0100001 "HP:0010456" ; a owl:Class ; rdfs:label "obsolete Abnormality of the sacroiliac notch" ; owl:deprecated true . obo:HP_0030267 obo:IAO_0000115 "Deposition of calcium salts in the fibrous sheet that connects the radius and the ulna." ; oboInOwl:hasDbXref "UMLS:C4022549" ; a owl:Class ; rdfs:label "Calcification of the interosseus membrane of the forearm" ; rdfs:subClassOf obo:HP_0002973 . obo:HP_0030268 obo:IAO_0000115 "Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing." ; oboInOwl:hasDbXref "UMLS:C4022548" ; a owl:Class ; rdfs:label "Hyperplastic callus formation" ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0030269 obo:IAO_0000115 "An elevated level of insulin-like growth factor 1 (IGF1) in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C2676198" ; oboInOwl:hasExactSynonym "Elevated serum IGF1", "Increased serum IGF1", "Increased serum insulin-like growth factor 1" ; a owl:Class ; rdfs:comment "Growth hormone and IGF-I are important regulators of bone homeostasis throughout life. During the prepubertal period, GH and IGF-I are determinants of longitudinal bone growth, skeletal maturation, and acquisition of bone mass, whereas in adults they are important in the maintenance of bone mass." ; rdfs:label "Increased circulating insulin-like growth factor 1 concentration" ; rdfs:subClassOf obo:HP_0030352 . obo:HP_0030270 obo:IAO_0000115 "Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine." ; oboInOwl:hasDbXref "UMLS:C4022547" ; a owl:Class ; rdfs:label "Elevated red cell adenosine deaminase level" ; rdfs:subClassOf obo:HP_0030272 . obo:HP_0030271 obo:IAO_0000115 "This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation." ; oboInOwl:hasDbXref "UMLS:C4022546" ; a owl:Class ; rdfs:label "Reduced erythrocyte 2,3-diphosphoglycerate concentration" ; rdfs:subClassOf obo:HP_0034737 . obo:HP_0030272 obo:IAO_0000115 "An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme." ; oboInOwl:hasDbXref "UMLS:C4022545" ; a owl:Class ; rdfs:label "Abnormal erythrocyte enzyme level" ; rdfs:subClassOf obo:HP_0001877, obo:HP_0012379 . obo:HP_0030273 obo:IAO_0000115 "Decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine." ; oboInOwl:hasDbXref "UMLS:C4022544" ; a owl:Class ; rdfs:label "Reduced red cell adenosine deaminase level" ; rdfs:subClassOf obo:HP_0030272 . obo:HP_0030274 obo:IAO_0000115 "Additional scrotum, or part of a scrotum in an abnormal location." ; oboInOwl:hasDbXref "UMLS:C4022543" ; oboInOwl:hasExactSynonym "Extra scrotum" ; a owl:Class ; rdfs:comment "An accessory scrotum is typically located on the perineum, frequently associated with perineal lipoma, and occasionally with Hypospadias or Bifid penis, which should be coded separately." ; rdfs:label "Accessory scrotum" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0030275 obo:IAO_0000115 "Scrotum in a position other than the usual position inferior to the base of the penis." ; oboInOwl:hasDbXref "UMLS:C4022542" ; oboInOwl:hasExactSynonym "Abnormal scrotum position" ; a owl:Class ; rdfs:comment "This term is distinguished from Accessory scrotum, as there is no significant scrotal tissue in the normal position in ectopic scrotum. This definition excludes the finding of Penoscrotal transposition or Overriding scrotum. Usually the scrotum is split and there is unilateral ectopia. The ectopic scrotum is typically located supra-inguinally, but may be located elsewhere such as on the upper thigh. A testis is commonly present in the ectopic scrotum. Ectopic scrotum can be accompanied by Chordee or Bifid penis, which should be coded separately, and by renal and non-urogenital malformations." ; rdfs:label "Ectopic scrotum" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0030276 obo:IAO_0100001 "HP:0000046" ; a owl:Class ; rdfs:label "obsolete Small scrotum" ; owl:deprecated true . obo:HP_0030277 obo:IAO_0000115 "Abnormal morphology of a vertebral pedical." ; oboInOwl:hasDbXref "UMLS:C4022541" ; a owl:Class ; rdfs:comment "The pedicle is part of the lumbar vertebrae - each lumbar vertebra consists of a vertebral body and a vertebral arch. The vertebral arch, consisting of a pair of pedicles and a pair of laminae, encloses the vertebral foramen." ; rdfs:label "Abnormal vertebral pedicle morphology" ; rdfs:subClassOf obo:HP_0008438 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030278 obo:IAO_0000115 "Underdeveloped vertebral pedicle." ; oboInOwl:hasDbXref "UMLS:C4022540" ; a owl:Class ; rdfs:label "Hypoplastic vertebral pedicle" ; rdfs:subClassOf obo:HP_0030277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030279 obo:IAO_0000115 "Underdeveloped pedicle of the fifth lumbar vertebra." ; oboInOwl:hasDbXref "UMLS:C4022539" ; a owl:Class ; rdfs:label "Hypoplastic L5 vertebral pedicle" ; rdfs:subClassOf obo:HP_0030278 . obo:HP_0030280 obo:IAO_0000115 "Radiolucent focal defect of a rib shaft." ; oboInOwl:hasDbXref "SNOMEDCT_US:249705009", "UMLS:C0426827" ; oboInOwl:hasExactSynonym "Rib gap" ; a owl:Class ; rdfs:comment "A rib gap can be congenital or acquired. If congenital this feature is nearly pathgnomonic for Cerebrocostomandibular syndrome (MIM:117650). Acquired rib gaps can be seen after surgical procedures or with fractures or infections." ; rdfs:label "Rib gap" ; rdfs:subClassOf obo:HP_0000772 . obo:HP_0030281 obo:IAO_0000115 "Fusion of cervical vertebrae at C3 and C4, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development." ; oboInOwl:hasDbXref "UMLS:C4022538" ; a owl:Class ; rdfs:label "Cervical C3/C4 vertebral fusion" ; rdfs:subClassOf obo:HP_0002949 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004612 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030282 obo:IAO_0000115 "Radiolucent focal defect of the posterior portion of a rib shaft. The 'gaps' may lead to flail chest." ; oboInOwl:hasDbXref "UMLS:C1842696" ; oboInOwl:hasExactSynonym "Dorsal rib defect" ; a owl:Class ; rdfs:label "Posterior rib gap" ; rdfs:subClassOf obo:HP_0030280 . obo:HP_0030283 obo:IAO_0000115 "Only part of the septum pellucidum (a thin, triangular, vertical membrane separating the lateral ventricles of the brain) is present. This feature can be appreciated on magnetic resonance tomography or computed tomography of the brain." ; oboInOwl:hasDbXref "SNOMEDCT_US:422474003", "UMLS:C1827299" ; a owl:Class ; rdfs:label "Partial absence of the septum pellucidum" ; rdfs:subClassOf obo:HP_0007375 . obo:HP_0030284 obo:IAO_0000115 "A form of macrogloassia (increased size of the tongue) characterized by a broad based root of the tongue but a small tongue tip, giving the appearance of a triangle." ; oboInOwl:hasDbXref "UMLS:C4022537" ; oboInOwl:hasExactSynonym "Triangle shaped tongue", "Triangular tongue" ; a owl:Class ; rdfs:label "Triangular tongue" ; rdfs:subClassOf obo:HP_0000158 . obo:HP_0030285 obo:IAO_0000115 "Abnormal splayed configuration (spreading out) of the superior cerebellar peduncle." ; oboInOwl:hasDbXref "UMLS:C4022536" ; a owl:Class ; rdfs:label "Splayed superior cerebellar peduncle" ; rdfs:subClassOf obo:HP_0011932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030286 obo:IAO_0000115 "Atrophy of the superior cerebellar peduncle." ; oboInOwl:hasDbXref "UMLS:C4022535" ; a owl:Class ; rdfs:label "Atrophic superior cerebellar peduncle" ; rdfs:subClassOf obo:HP_0011932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030289 obo:IAO_0000115 "An abnormal flattening of an epiphysis of femur." ; oboInOwl:hasDbXref "UMLS:C1850642" ; oboInOwl:hasExactSynonym "Flattended end part of thigh bone" ; a owl:Class ; rdfs:label "Flattened femoral epiphysis" ; rdfs:subClassOf obo:HP_0003071 . obo:HP_0030290 obo:IAO_0000115 "Lack of ossification of the sacrum." ; oboInOwl:hasDbXref "UMLS:C2675562" ; oboInOwl:hasExactSynonym "Absence of sacrum ossification" ; a owl:Class ; rdfs:label "Unossified sacrum" ; rdfs:subClassOf obo:HP_0025370 ; owl:equivalentClass _:genid89164 . obo:HP_0030291 obo:IAO_0000115 "Irregularity of the normally smooth surface of one or more metaphyses of a bone of the leg." ; oboInOwl:hasDbXref "UMLS:C4022534" ; a owl:Class ; rdfs:label "Lower-limb metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0003025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030292 obo:IAO_0000115 "Irregularity of the normally smooth surface of a metaphysis of a tibia." ; oboInOwl:hasDbXref "UMLS:C4022533" ; a owl:Class ; rdfs:label "Tibial metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0030291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013750 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030293 obo:IAO_0000115 "Irregularity of the normally smooth surface of a metaphysis of a fibula." ; oboInOwl:hasDbXref "UMLS:C4022532" ; oboInOwl:hasExactSynonym "Irregularity of wide portion of calf bone" ; a owl:Class ; rdfs:label "Fibular metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0030291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0016928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030294 oboInOwl:hasDbXref "UMLS:C4022531" ; a owl:Class ; rdfs:label "Metaphyseal chondromatosis of tibia" ; rdfs:subClassOf obo:HP_0005868 . obo:HP_0030295 oboInOwl:hasDbXref "UMLS:C4022530" ; a owl:Class ; rdfs:label "Metaphyseal chondromatosis of femur" ; rdfs:subClassOf obo:HP_0005868 . obo:HP_0030296 oboInOwl:hasDbXref "UMLS:C4022529" ; a owl:Class ; rdfs:label "Metaphyseal chondromatosis of radius" ; rdfs:subClassOf obo:HP_0005868 . obo:HP_0030297 oboInOwl:hasDbXref "UMLS:C4022528" ; a owl:Class ; rdfs:label "Metaphyseal chondromatosis of ulna" ; rdfs:subClassOf obo:HP_0005868 . obo:HP_0030298 oboInOwl:hasDbXref "UMLS:C4021860" ; a owl:Class ; rdfs:label "Metaphyseal chondromatosis of humerus" ; rdfs:subClassOf obo:HP_0005868 . obo:HP_0030299 obo:IAO_0000115 "An anomaly of the metaphysis of the distal femur (close to the knee)." ; oboInOwl:hasDbXref "UMLS:C4022527" ; oboInOwl:hasExactSynonym "Abnormality of wide portion of outermost thighbone" ; a owl:Class ; rdfs:label "Distal femoral metaphyseal abnormality" ; rdfs:subClassOf obo:HP_0006489 . obo:HP_0030300 obo:IAO_0000115 "Presence of only 10 (instead of the usual 12) pairs of ribs." ; oboInOwl:hasDbXref "UMLS:C4022526" ; oboInOwl:hasExactSynonym "10 pairs of ribs" ; a owl:Class ; rdfs:label "10 pairs of ribs" ; rdfs:subClassOf obo:HP_0000921 . obo:HP_0030301 obo:IAO_0000115 "An anomaly of the anterior commissure, a bundle of nerve fibers that connect the two cerebral hemispheres across the midline. The anterior commissure plays a role in pain sensation and contains decussating fibers from the olfactory tracts." ; oboInOwl:hasDbXref "UMLS:C4022525" ; a owl:Class ; rdfs:comment "The human brain commissures comprise the corpus callosum, the anterior commissure, the fornix, and the posterior commissure." ; rdfs:label "Abnormality of the anterior commissure" ; rdfs:subClassOf obo:HP_0002500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030302 obo:IAO_0000115 "Absence of the anterior commissure." ; oboInOwl:hasDbXref "UMLS:C1851087" ; a owl:Class ; rdfs:label "Agenesis of the anterior commissure" ; rdfs:subClassOf obo:HP_0030301 . obo:HP_0030303 obo:IAO_0000115 "Underdevelopment of the anterior commissure." ; oboInOwl:hasDbXref "UMLS:C4022524" ; a owl:Class ; rdfs:label "Hypoplastic anterior commissure" ; rdfs:subClassOf obo:HP_0030301 . obo:HP_0030304 obo:IAO_0000115 "A deviation from the normal number of vertebrae in the spinal column." ; oboInOwl:hasDbXref "UMLS:C4022523" ; a owl:Class ; rdfs:label "Abnormal number of vertebrae" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0030305 oboInOwl:hasDbXref "UMLS:C4022522" ; a owl:Class ; rdfs:label "Decreased number of vertebrae" ; rdfs:subClassOf obo:HP_0030304 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030306 obo:IAO_0000115 "The presence of 11 instead of the normal 12 thoracic vertebrae." ; oboInOwl:hasDbXref "UMLS:C4022521" ; a owl:Class ; rdfs:label "11 thoracic vertebrae" ; rdfs:subClassOf obo:HP_0030305 . obo:HP_0030307 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the leg." ; oboInOwl:hasDbXref "UMLS:C4022520" ; oboInOwl:hasExactSynonym "Flared metaphysis of lower limb bone" ; a owl:Class ; rdfs:label "Flared lower limb metaphysis" ; rdfs:subClassOf obo:HP_0003015 . obo:HP_0030308 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of the distal tibia." ; oboInOwl:hasDbXref "UMLS:C4022519" ; oboInOwl:hasExactSynonym "Flared outermost metaphysis of shankbone", "Flared outermost metaphysis of shinbone" ; a owl:Class ; rdfs:label "Flared distal tibial metaphysis" ; rdfs:subClassOf obo:HP_0030307 . obo:HP_0030309 obo:IAO_0000115 "The presence of a splayed (i.e.,flared) metaphyseal segment of the distal fibula." ; oboInOwl:hasDbXref "UMLS:C4022518" ; oboInOwl:hasExactSynonym "Flared outermost wide portion of of calf bone" ; a owl:Class ; rdfs:label "Flared distal fibular metaphysis" ; rdfs:subClassOf obo:HP_0030307 . obo:HP_0030310 obo:IAO_0000115 "Displacement or malalignment of one or more joints in the upper extremity (arm)." ; oboInOwl:hasDbXref "UMLS:C4022517" ; oboInOwl:hasExactSynonym "Dislocated arm joints" ; a owl:Class ; rdfs:label "Upper extremity joint dislocation" ; rdfs:subClassOf obo:HP_0001373 . obo:HP_0030311 obo:IAO_0000115 "Displacement or malalignment of one or more joints in the lower extremity (leg)." ; oboInOwl:hasDbXref "UMLS:C4022516" ; oboInOwl:hasExactSynonym "Dislocated leg joints" ; a owl:Class ; rdfs:label "Lower extremity joint dislocation" ; rdfs:subClassOf obo:HP_0001373 . obo:HP_0030312 obo:IAO_0000115 "Absence of the spongy bone structure (or tissue) of the internal part of the skull cap (i.e., of the calvarial diploe)." ; oboInOwl:hasDbXref "UMLS:C1860855" ; oboInOwl:hasExactSynonym "Obliteration of cranial cancellous bone" ; a owl:Class ; rdfs:label "Obliteration of the calvarial diploe" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0030313 obo:IAO_0000115 "An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones." ; oboInOwl:hasAlternativeId "HP:0040166" ; oboInOwl:hasDbXref "UMLS:C4022515" ; a owl:Class ; rdfs:label "Abnormal periosteum morphology" ; rdfs:subClassOf obo:HP_0003330, obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002515 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030314 obo:IAO_0000115 "Abnormal deposition of periosteal bone." ; oboInOwl:hasDbXref "UMLS:C1409412" ; a owl:Class ; rdfs:label "Periostosis" ; rdfs:subClassOf obo:HP_0030313 . obo:HP_0030318 obo:IAO_0000115 "A type of inflammation of the lips involving one or both of the corners of the mouth." ; oboInOwl:hasDbXref "SNOMEDCT_US:266429005", "UMLS:C0221237" ; oboInOwl:hasExactSynonym "Angular cheilosis", "Angular stomatitis", "Commissural cheilitis", "Inflammation of corners of the mouth", "Inflammation of oral commisures", "Red and sore corners of the mouth" ; a owl:Class ; rdfs:label "Angular cheilitis" ; rdfs:subClassOf obo:HP_0100825 . obo:HP_0030319 obo:IAO_0000115 "Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." ; oboInOwl:hasDbXref "UMLS:C4022514" ; oboInOwl:hasExactSynonym "Decreased facial muscle strength", "Decreased strength of facial muscles", "Face weakness", "Facial muscle weakness", "Facial weakness", "Myasthenia of facial muscles", "Reduced facial muscle strength", "Weakness of face", "Weakness of facial musculature" ; a owl:Class ; rdfs:label "Weakness of facial musculature" ; rdfs:subClassOf obo:HP_0000301 . obo:HP_0030320 obo:IAO_0000115 "An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disc space." ; oboInOwl:hasDbXref "UMLS:C4022513" ; a owl:Class ; rdfs:label "Increased intervertebral space" ; rdfs:subClassOf obo:HP_0005108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000570 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030321 obo:IAO_0000115 "An anomaly of the vertebral artery, the major artery of the neck that originates from the subclavian artery and merges to form the single midline basilar artery in a complex called the vertebrobasilar system." ; oboInOwl:hasDbXref "UMLS:C4022512" ; oboInOwl:hasExactSynonym "Abnormality of the vertebral artery" ; a owl:Class ; rdfs:label "Abnormal vertebral artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030322 obo:IAO_0000115 "Underdevelopment of the vertebral artery." ; oboInOwl:hasDbXref "UMLS:C1868737" ; a owl:Class ; rdfs:label "Vertebral artery hypoplasia" ; rdfs:subClassOf obo:HP_0030321 . obo:HP_0030323 obo:IAO_0000115 "Underdevelopment of the vertebral artery on one side." ; oboInOwl:hasDbXref "UMLS:C3279090" ; a owl:Class ; rdfs:label "Unilateral vertebral artery hypoplasia" ; rdfs:subClassOf obo:HP_0030322 . obo:HP_0030324 obo:IAO_0000115 "Underdevelopment of the vertebral artery on both sides." ; oboInOwl:hasDbXref "UMLS:C4022511" ; a owl:Class ; rdfs:label "Bilateral vertebral artery hypoplasia" ; rdfs:subClassOf obo:HP_0030322 . obo:HP_0030325 obo:IAO_0000115 "Fissure within the spinal cord of the neck." ; oboInOwl:hasDbXref "UMLS:C4022510" ; a owl:Class ; rdfs:label "Cervicomedullary schisis" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0030326 obo:IAO_0000115 "An anomaly in the number of macrophages." ; oboInOwl:hasDbXref "UMLS:C4022509" ; a owl:Class ; rdfs:label "Abnormal macrophage count" ; rdfs:subClassOf obo:HP_0004311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030327 obo:IAO_0000115 "An anomaly in the number of osteoclasts in bone tissue, bone-resorbing cells that develop from macrophages. This finding can be observed by histological examination of bone tissue." ; oboInOwl:hasDbXref "UMLS:C4022508" ; a owl:Class ; rdfs:label "Abnormal osteoclast count" ; rdfs:subClassOf obo:HP_0003330 . obo:HP_0030328 obo:IAO_0000115 "Decreased number of osteoclasts in bone tissue." ; oboInOwl:hasDbXref "UMLS:C4022507" ; a owl:Class ; rdfs:label "Decreased osteoclast count" ; rdfs:subClassOf obo:HP_0030327 . obo:HP_0030329 obo:IAO_0000115 "Reduced anteroposterior thickness of the retina. This phenotype can be appreciated by retinal optical coherence tomography (OCT)." ; oboInOwl:hasDbXref "UMLS:C3549703" ; oboInOwl:hasExactSynonym "Retinal thinning" ; a owl:Class ; rdfs:label "Retinal thinning" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0030330 obo:IAO_0000115 "The presence of cartilage cells (chondrocytes) that are substantially increased in size and contain more than one nucleus and are located within the resting zone of the epiphyseal cartilage." ; oboInOwl:hasDbXref "UMLS:C4022506" ; a owl:Class ; rdfs:label "Multinucleated giant chondrocytes in epiphyseal cartilage" ; rdfs:subClassOf obo:HP_0005930, obo:HP_0032929 . obo:HP_0030331 obo:IAO_0000115 "A reduced ability of the skin of the fingertips to wrinkle when exposed to stimuli such as soaking in water or application of EMLA cream (the fingertip remains smooth)." ; oboInOwl:hasDbXref "UMLS:C4022505" ; a owl:Class ; rdfs:label "Impaired stimulus-induced skin wrinkling" ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0030332 obo:IAO_0100001 "HP:0002843" ; a owl:Class ; rdfs:label "obsolete Abnormal T cell morphology" ; owl:deprecated true . obo:HP_0030333 obo:IAO_0000115 "A structuraly anomaly of T cells that express an alpha-beta T cell receptor." ; oboInOwl:hasDbXref "UMLS:C4022503" ; a owl:Class ; rdfs:comment "Normally, most T cells express a T cell receptor (TCR) that consists of an alpha and a beta chain. A smaller subset of T cells express a TCR consisting of gamma and delta chains," ; rdfs:label "Abnormal alpha-beta T cell morphology" ; rdfs:subClassOf obo:HP_0002843 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000789 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030334 obo:IAO_0000115 "A structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell. These cells are regulatory T cells." ; oboInOwl:hasDbXref "UMLS:C4022502" ; a owl:Class ; rdfs:label "Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology" ; rdfs:subClassOf obo:HP_0030333 . obo:HP_0030335 obo:IAO_0000115 "A deviation from the normal count of CD4-positive, CD25-positive, alpha-beta regulatory T cells." ; oboInOwl:hasDbXref "UMLS:C4021859" ; a owl:Class ; rdfs:label "Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell count" ; rdfs:subClassOf obo:HP_0030334 . obo:HP_0030336 obo:IAO_0000115 "Lack of CD4+CD25+ T regulatory cells." ; oboInOwl:hasDbXref "UMLS:C4021039" ; oboInOwl:hasExactSynonym "Absence of CD4+CD25+ T regulatory cells", "Absence of CD4+CD25+ Tregs" ; a owl:Class ; rdfs:label "Absence of CD4-positive, CD25-positive regulatory T cells" ; rdfs:subClassOf obo:HP_0030335 . obo:HP_0030337 obo:IAO_0000115 "An increased number of CD4-positive, CD25-positive regulatory T cells." ; oboInOwl:hasDbXref "UMLS:C4022501" ; a owl:Class ; rdfs:label "Elevated CD4-positive, CD25-positive regulatory T cell count" ; rdfs:subClassOf obo:HP_0030335 . obo:HP_0030338 obo:IAO_0000115 "An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." ; oboInOwl:hasDbXref "UMLS:C4072886" ; oboInOwl:hasExactSynonym "Abnormal circulating gonadotropin level" ; a owl:Class ; rdfs:label "Abnormal circulating gonadotropin concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0061696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030339 obo:IAO_0000115 "A reduction of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." ; oboInOwl:hasDbXref "UMLS:C4072887" ; oboInOwl:hasExactSynonym "Decreased circulating gonadotropin level" ; a owl:Class ; rdfs:label "Decreased circulating gonadotropin concentration" ; rdfs:subClassOf obo:HP_0030338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0061696 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030340 obo:IAO_0100001 "HP:0000837" ; a owl:Class ; rdfs:label "obsolete Increased circulating gonadotropin level" ; owl:deprecated true . obo:HP_0030341 obo:IAO_0000115 "A reduction of the circulating level of follicle-stimulating hormone (FSH)." ; oboInOwl:hasDbXref "UMLS:C4072889" ; oboInOwl:hasExactSynonym "Decreased circulating follicle stimulating hormone level" ; a owl:Class ; rdfs:label "Decreased circulating follicle stimulating hormone concentration" ; rdfs:subClassOf obo:HP_0030339, obo:HP_0030346 . obo:HP_0030344 obo:IAO_0000115 "A reduction in the circulating level of luteinizing hormone (LH)." ; oboInOwl:hasDbXref "UMLS:C4072890" ; oboInOwl:hasExactSynonym "Decreased circulating luteinising hormone level" ; a owl:Class ; rdfs:label "Decreased circulating luteinizing hormone level" ; rdfs:subClassOf obo:HP_0030339, obo:HP_0030345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_81568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030345 obo:IAO_0000115 "An anomaly of the circulating level of luteinizing hormone (LH)." ; oboInOwl:hasDbXref "SNOMEDCT_US:166374003", "UMLS:C0580438" ; oboInOwl:hasExactSynonym "Abnormal circulating luteinizing hormone level", "Abnormal luteinizing hormone level", "Increased circulating lutropin" ; a owl:Class ; rdfs:label "Abnormal circulating luteinizing hormone concentration" ; rdfs:subClassOf obo:HP_0030338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_81568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030346 obo:IAO_0000115 "An anomaly of the circulating level of follicle-stimulating hormone (FSH)." ; oboInOwl:hasDbXref "UMLS:C4072891" ; oboInOwl:hasExactSynonym "Abnormal circulating follicle-stimulating hormone level" ; a owl:Class ; rdfs:label "Abnormal circulating follicle-stimulating hormone concentration" ; rdfs:subClassOf obo:HP_0030338 . obo:HP_0030347 obo:IAO_0000115 "An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." ; oboInOwl:hasDbXref "UMLS:C4072892" ; a owl:Class ; rdfs:label "Abnormal circulating androgen level" ; rdfs:subClassOf obo:HP_0033799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030348 obo:IAO_0000115 "An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." ; oboInOwl:hasDbXref "UMLS:C4072893" ; oboInOwl:hasExactSynonym "Hyperandrogenemia", "Increased circulating androgen level" ; a owl:Class ; rdfs:label "Increased circulating androgen concentration" ; rdfs:subClassOf obo:HP_0030347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030349 obo:IAO_0000115 "A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." ; oboInOwl:hasDbXref "UMLS:C4072894" ; oboInOwl:hasExactSynonym "Decreased circulating androgen level" ; a owl:Class ; rdfs:label "Decreased circulating androgen concentration" ; rdfs:subClassOf obo:HP_0030347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_50113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030350 obo:IAO_0000115 "A circumscribed, solid elevation of skin with no visible fluid that is reddish (erythematous) in color." ; oboInOwl:hasDbXref "UMLS:C0747241" ; oboInOwl:hasRelatedSynonym "Red-blue papule" ; a owl:Class ; rdfs:label "Erythematous papule" ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0030351 obo:IAO_0000115 "A well-circumscribed, intensely pruritic, raised wheal (edema of the superficial skin) typically 1 to 2 cm in diameter." ; oboInOwl:hasDbXref "UMLS:C4072895" ; a owl:Class ; rdfs:label "Urticarial plaque" ; rdfs:subClassOf obo:HP_0200035 . obo:HP_0030352 obo:IAO_0000115 "An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4072896" ; a owl:Class ; rdfs:label "Abnormal serum insulin-like growth factor 1 level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0030353 obo:IAO_0000115 "A reduced level of insulin-like growth factor 1 (IGF1) in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4072897" ; a owl:Class ; rdfs:label "Decreased serum insulin-like growth factor 1" ; rdfs:subClassOf obo:HP_0030352 . obo:HP_0030354 obo:IAO_0000115 "Abnormal levels of interferon in the blood." ; oboInOwl:hasDbXref "UMLS:C4072898" ; oboInOwl:hasExactSynonym "Abnormal serum interferon level" ; a owl:Class ; rdfs:label "Abnormal circulating interferon concentration" ; rdfs:subClassOf obo:HP_0011112 . obo:HP_0030355 obo:IAO_0000115 "Abnormal levels of interferon gamma measured in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4072899" ; oboInOwl:hasExactSynonym "Abnormal serum interferon-gamma level" ; a owl:Class ; rdfs:label "Abnormal circulating interferon-gamma concentration" ; rdfs:subClassOf obo:HP_0030354 . obo:HP_0030356 obo:IAO_0000115 "An elevation in the concentration of interferon gamma measured in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4072900" ; oboInOwl:hasExactSynonym "Increased serum interferon-gamma level" ; a owl:Class ; rdfs:label "Increased circulating interferon-gamma concentration" ; rdfs:subClassOf obo:HP_0030355 . obo:HP_0030357 obo:IAO_0000115 "Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly." ; oboInOwl:hasDbXref "MSH:D055752", "SNOMEDCT_US:254632001", "SNOMEDCT_US:254633006", "UMLS:C0149925" ; oboInOwl:hasExactSynonym "Oat cell carcinoma of lung", "Oat cell lung cancer", "Small cell lung cancer" ; a owl:Class ; rdfs:label "Small cell lung carcinoma" ; rdfs:subClassOf obo:HP_0100526 . obo:HP_0030358 oboInOwl:hasDbXref "MSH:D002289", "SNOMEDCT_US:254637007", "UMLS:C0007131" ; oboInOwl:hasExactSynonym "Non-small cell lung cancer" ; a owl:Class ; rdfs:label "Non-small cell lung carcinoma" ; rdfs:subClassOf obo:HP_0100526 . obo:HP_0030359 obo:IAO_0000115 "A type of non-small cell lung carcinoma that is derived from stratified squamous epithelial cells." ; oboInOwl:hasDbXref "SNOMEDCT_US:254634000", "UMLS:C0149782" ; a owl:Class ; rdfs:comment "Four subtypes of squamous cell lung carcinoma exist: (i) papillary; (ii) clear cell; (iii) small cell (distinct from small cell lung cancer); and (iv) basaloid." ; rdfs:label "Squamous cell lung carcinoma" ; rdfs:subClassOf obo:HP_0030358 . obo:HP_0030360 obo:IAO_0000115 "A type of non-small cell lung carcinoma that is derived from undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung, and which is differentiate from small-cell lung carcinoma by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of salt-and-pepper appearance of the chromatin." ; oboInOwl:hasDbXref "SNOMEDCT_US:254629004", "UMLS:C0345958" ; a owl:Class ; rdfs:label "Large cell lung carcinoma" ; rdfs:subClassOf obo:HP_0030358 . obo:HP_0030361 obo:IAO_0000115 "Any deviation from the normal concentration in the blood circulation of an icosanoid (also known as eicosanoids). These are signaling molecules derived from oxidation of 20-carbon fatty acids. Most are produced from arachidonic acid, a 20-carbon polyunsaturated fatty acid (5,8,11,14-eicosatetraenoic acid)." ; oboInOwl:hasDbXref "UMLS:C4072901" ; oboInOwl:hasExactSynonym "Abnormality of icosanoid metabolism" ; a owl:Class ; rdfs:comment "The icosanoids include the prostaglandins, prostacyclins, thromboxanes, leukotrienes, and epoxyeicosatrienoic acids. Icosanoids have various roles in processes that regulate inflammation, fever, blood pressure, blood clotting, immune system function, reproductive processes and tissue growth, and the sleep/wake cycle." ; rdfs:label "Abnormal circulating eicosanoid concentration" ; rdfs:subClassOf obo:HP_0011022 . obo:HP_0030362 obo:IAO_0000115 "A reduction in the level of carnitine in muscle tissue." ; oboInOwl:hasDbXref "UMLS:C4072902" ; a owl:Class ; rdfs:comment "Carnitine deficiency may be observed in a systemic form or be limited to skeletal muscle tissue. Carnitine levels can be measured by assays of muscle tissue (biopsy). Alternatively, 1H-NMR spectroscopy can be used for qualitative measurement of muscle carnitine levels." ; rdfs:label "Reduced muscle carnitine level" ; rdfs:subClassOf obo:HP_0034370 . obo:HP_0030363 obo:IAO_0000115 "Delivery by Caesarian section representing the first time the mother has delivered by Caesarian section." ; oboInOwl:hasDbXref "UMLS:C4072903" ; a owl:Class ; rdfs:label "Primary Caesarian section" ; rdfs:subClassOf obo:HP_0011410 . obo:HP_0030364 obo:IAO_0000115 "Delivery by Caesarian section representing where the mother has already had a previous Cesarean delivery, and this is a repeat Cesarean birth." ; oboInOwl:hasDbXref "UMLS:C4072904" ; a owl:Class ; rdfs:label "Secondary Caesarian section" ; rdfs:subClassOf obo:HP_0011410 . obo:HP_0030365 obo:IAO_0000115 "Vaginal birth after Caesarian (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally." ; oboInOwl:hasDbXref "MSH:D016064", "UMLS:C0080301" ; a owl:Class ; rdfs:label "Vaginal birth after Caesarian" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0030366 obo:IAO_0000115 "The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process." ; oboInOwl:hasDbXref "UMLS:C4072905" ; a owl:Class ; rdfs:label "Delivery by Odon device" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0030367 obo:IAO_0000115 "Hyperphalangy is a digit morphology in which increased numbers of phalanges are arranged linearly within a digit. That is, there is an accessory phalanx that is arranged linearly with the other phalanges." ; oboInOwl:hasDbXref "UMLS:C4072906" ; a owl:Class ; rdfs:label "Finger hyperphalangy" ; rdfs:subClassOf obo:HP_0005918 . obo:HP_0030368 obo:IAO_0000115 "An accessory phalanx of the index (second) finger that is arranged linearly with the other phalanges. Hyperphalangy of the index finger results from an accessory ossification center at the metacarpophalangeal joint, resulting in radial deviation of the index finger. Note that this term refers only to this type of hyperphalangy." ; oboInOwl:hasDbXref "UMLS:C4072907" ; oboInOwl:hasExactSynonym "Hyperphalangy of index finger" ; a owl:Class ; rdfs:label "Hyperphalangy of the 2nd finger" ; rdfs:subClassOf obo:HP_0030367 . obo:HP_0030369 obo:IAO_0000115 "Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own." ; oboInOwl:hasDbXref "UMLS:C4072908" ; a owl:Class ; rdfs:label "Induced vaginal delivery" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0030370 obo:IAO_0000115 "A deviation in the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to the total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." ; oboInOwl:hasDbXref "UMLS:C4072909" ; a owl:Class ; rdfs:label "Abnormal proportion of naive B cells" ; rdfs:subClassOf obo:HP_0025539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030371 obo:IAO_0000115 "An elevation above the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." ; oboInOwl:hasDbXref "UMLS:C4072910" ; a owl:Class ; rdfs:label "Increased proportion of naive B cells" ; rdfs:subClassOf obo:HP_0030370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030372 obo:IAO_0000115 "A reduction below normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." ; oboInOwl:hasDbXref "UMLS:C4072911" ; a owl:Class ; rdfs:label "Decreased proportion of naive B cells" ; rdfs:subClassOf obo:HP_0030370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000788 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030373 obo:IAO_0000115 "A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." ; oboInOwl:hasDbXref "UMLS:C4072912" ; a owl:Class ; rdfs:comment "Memory B cells can be defined as CD19+/CD27+ or CD20+/CD27+ cells in flow cytometry." ; rdfs:label "Abnormal proportion of memory B cells" ; rdfs:subClassOf obo:HP_0025539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030374 obo:IAO_0000115 "A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." ; oboInOwl:hasDbXref "UMLS:C4072913" ; a owl:Class ; rdfs:label "Decreased proportion of memory B cells" ; rdfs:subClassOf obo:HP_0030373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030375 obo:IAO_0000115 "An elevation in the proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." ; oboInOwl:hasDbXref "UMLS:C4072914" ; a owl:Class ; rdfs:label "Increased proportion of memory B cells" ; rdfs:subClassOf obo:HP_0030373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000787 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030376 obo:IAO_0000115 "A deviation from normal proportion of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." ; oboInOwl:hasDbXref "UMLS:C4072915" ; oboInOwl:hasExactSynonym "Abnormal proportion of CD19+/CD21low B cells" ; a owl:Class ; rdfs:label "Abnormal proportion of immature B cells" ; rdfs:subClassOf obo:HP_0025539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030377 obo:IAO_0000115 "An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." ; oboInOwl:hasDbXref "UMLS:C4072916" ; oboInOwl:hasExactSynonym "Increased proportion of CD19+/CD21low B cells" ; a owl:Class ; rdfs:label "Increased proportion of immature B cells" ; rdfs:subClassOf obo:HP_0030376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030378 obo:IAO_0000115 "A reduction in normal proportion of immature B cells (CD19+/ CD21low)in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." ; oboInOwl:hasDbXref "UMLS:C4072917" ; oboInOwl:hasExactSynonym "Decreased proportion of CD19+/CD21low B cells" ; a owl:Class ; rdfs:label "Decreased proportion of immature B cells" ; rdfs:subClassOf obo:HP_0030376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000816 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030379 obo:IAO_0000115 "A deviation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." ; oboInOwl:hasDbXref "UMLS:C4072918" ; oboInOwl:hasExactSynonym "Abnormal proportion of CD19+CD38+IgM+ cells" ; a owl:Class ; rdfs:label "Abnormal proportion of transitional B cells" ; rdfs:subClassOf obo:HP_0025539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030380 obo:IAO_0000115 "A reduction in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." ; oboInOwl:hasDbXref "UMLS:C4072919" ; oboInOwl:hasExactSynonym "Decreased proportion of CD19+CD38+IgM+ cells" ; a owl:Class ; rdfs:label "Decreased proportion of transitional B cells" ; rdfs:subClassOf obo:HP_0030379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030381 obo:IAO_0000115 "An elevation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." ; oboInOwl:hasDbXref "UMLS:C4072920" ; oboInOwl:hasExactSynonym "Increased proportion of CD19+CD38+IgM+ cells" ; a owl:Class ; rdfs:label "Increased proportion of transitional B cells" ; rdfs:subClassOf obo:HP_0030379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000818 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030383 obo:IAO_0000115 "A deviation of the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." ; oboInOwl:hasDbXref "UMLS:C4072921" ; a owl:Class ; rdfs:label "Abnormal proportion of marginal zone B cells" ; rdfs:subClassOf obo:HP_0030373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000845 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030384 obo:IAO_0000115 "A reduction in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." ; oboInOwl:hasDbXref "UMLS:C4072922" ; a owl:Class ; rdfs:label "Decreased proportion of marginal zone B cells" ; rdfs:subClassOf obo:HP_0030383 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000845 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030385 obo:IAO_0000115 "An elevation in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." ; oboInOwl:hasDbXref "UMLS:C4072923" ; a owl:Class ; rdfs:label "Increased proportion of marginal zone B cells" ; rdfs:subClassOf obo:HP_0030383 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000845 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030386 obo:IAO_0000115 "A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." ; oboInOwl:hasDbXref "UMLS:C4072924" ; oboInOwl:hasExactSynonym "Abnormal proportion of CD19+CD27+IgD- cells" ; a owl:Class ; rdfs:label "Abnormal proportion of class-switched memory B cells" ; rdfs:subClassOf obo:HP_0030373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030387 obo:IAO_0000115 "An increase in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." ; oboInOwl:hasDbXref "UMLS:C4073288" ; oboInOwl:hasExactSynonym "Increased proportion of CD19+CD27+IgD- cells" ; a owl:Class ; rdfs:label "Increased proportion of class-switched memory B cells" ; rdfs:subClassOf obo:HP_0030375, obo:HP_0030386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030388 obo:IAO_0000115 "A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." ; oboInOwl:hasDbXref "UMLS:C4072925" ; oboInOwl:hasExactSynonym "Decreased proportion of CD19+CD27+IgD- cells" ; a owl:Class ; rdfs:label "Decreased proportion of class-switched memory B cells" ; rdfs:subClassOf obo:HP_0030374, obo:HP_0030386 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000972 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030389 obo:IAO_0000115 "Any deivation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels." ; oboInOwl:hasDbXref "UMLS:C4072926" ; a owl:Class ; rdfs:label "Abnormal circulating thromboxane concentration" ; rdfs:subClassOf obo:HP_0030361 . obo:HP_0030390 obo:IAO_0000115 "An abnormally decreased concentration of leukotriene C4 in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4072927" ; a owl:Class ; rdfs:comment "Cysteinyl leukotrienes including LTC4 are potent lipid mediators derived from arachidonic acid in the 5 lipoxygenase pathway." ; rdfs:label "Reduced circulating leukotriene C4 concentration" ; rdfs:subClassOf obo:HP_0030361 . obo:HP_0030391 obo:IAO_0000115 "Reduced ability of lexical discrimination, which refers to the process of distinguishing a stimulus word from other phonologically similar words. Lexical discrimination can be defined as the process of correctly identifying words in the mental lexicon to match the phonological input of a stimulus." ; oboInOwl:hasDbXref "UMLS:C4072928" ; a owl:Class ; rdfs:label "Spoken word recognition deficit" ; rdfs:subClassOf obo:HP_0002463 . obo:HP_0030392 obo:IAO_0000115 "Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III." ; oboInOwl:hasDbXref "MSH:C562943", "SNOMEDCT_US:88252006", "UMLS:C0431109" ; a owl:Class ; rdfs:label "Choroid plexus carcinoma" ; rdfs:subClassOf obo:HP_0007376, obo:HP_0100836 . obo:HP_0030393 obo:IAO_0000115 "A low-grade papillary epithelial neoplasm (adenocarcinoma) with a slow growth pattern. The endolymphatic duct emerges from the posterior wall of the saccule (of the inner ear) and ends in a blind pouch, the endolymphatic sac. Endolymphatic sac tumors (ELSTs) are known under different names in the literature (Heffner tumor, aggressive papillary middle ear tumor, and low-grade adenocarcinoma of endolymphatic sac origin)." ; oboInOwl:hasDbXref "SNOMEDCT_US:699817008", "UMLS:C2348239" ; oboInOwl:hasExactSynonym "Aggressive papillary middle ear tumor", "Aggressive papillary middle ear tumour", "Endolymphatic sac tumour", "Heffner tumor", "Heffner tumour", "Low-grade adenocarcinoma of endolymphatic sac origin" ; a owl:Class ; rdfs:comment "Endolymphatic sac tumors (ELSTs) may arise sporadically or in von Hippel-Lindau (VHL) disease. The symptoms (hearing loss with or without tinnitus, vertigo, impairment of cranial nerve function) and the physical and neuro-otologic examination and imaging findings (computed tomography, magnetic resonance imaging) are not specific for tumors of the cerebellopontine angle (CPA). The final diagnosis can often only be reached through histopathological and immunohistochemical evaluation of the tumor specimen. The differential diagnosis in tumors of the CPA includes paraganglioma, chondroid tumor, atypical schwannoma, meningioma, and also rare entities such as aneurysm, hemangioblastoma, craniopharyngioma, and choroid plexus papilloma." ; rdfs:label "Endolymphatic sac tumor" ; rdfs:subClassOf obo:HP_0040096 . obo:HP_0030394 obo:IAO_0000115 "Carcinoma that originates in the Fallopian tube. It may be located in the wall or within the lumen as a growth attached to the wall by a stalk." ; oboInOwl:hasDbXref "MSH:D005185", "SNOMEDCT_US:276870001", "UMLS:C0238122" ; a owl:Class ; rdfs:label "Fallopian tube carcinoma" ; rdfs:subClassOf obo:HP_0033020 . obo:HP_0030396 obo:IAO_0000115 "Platelets are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules - alpha-granules, dense granules, and lysosomes - the alpha-granule is the most abundant. Granule contents must be released from their intracellular repository in order to achieve their physiologic function, and this term refers to a functional defect in granule secretion." ; oboInOwl:hasDbXref "UMLS:C4072929" ; a owl:Class ; rdfs:label "Abnormal platelet granule secretion" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0030397 obo:IAO_0000115 "Abnormal release of dense granules from platelets." ; oboInOwl:hasDbXref "UMLS:C4072930" ; a owl:Class ; rdfs:comment "Dense granules contain adenosine diphosphate, adenosine triphosphate, ionized calcium, histamine and serotonin." ; rdfs:label "Abnormal platelet dense granule secretion" ; rdfs:subClassOf obo:HP_0030396 . obo:HP_0030398 obo:IAO_0000115 "Abnormal secretion of the platelet dense-granule content adenosine triphosphate (ATP)." ; oboInOwl:hasDbXref "UMLS:C4072931" ; a owl:Class ; rdfs:label "Abnormal platelet ATP dense granule secretion" ; rdfs:subClassOf obo:HP_0030397 . obo:HP_0030399 obo:IAO_0000115 "Abnormal release of alpha granule contents from platelets." ; oboInOwl:hasDbXref "UMLS:C4072932" ; a owl:Class ; rdfs:label "Abnormal platelet alpha granule secretion" ; rdfs:subClassOf obo:HP_0030396 . obo:HP_0030400 obo:IAO_0000115 "Abnormal release of lysosome contents from platelets." ; oboInOwl:hasDbXref "UMLS:C4072933" ; a owl:Class ; rdfs:label "Abnormal platelet lysosome secretion" ; rdfs:subClassOf obo:HP_0030396 . obo:HP_0030401 obo:IAO_0000115 "Deviation from normal of the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) within platelets." ; oboInOwl:hasDbXref "UMLS:C4072934" ; a owl:Class ; rdfs:label "Abnormal platelet dense granule ATP/ADP ratio" ; rdfs:subClassOf obo:HP_0012484 . obo:HP_0030402 obo:IAO_0000115 "An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent." ; oboInOwl:hasDbXref "UMLS:C0541767" ; a owl:Class ; rdfs:label "Abnormal platelet aggregation" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0030403 obo:IAO_0000115 "Clumping together of platelets in the blood in a platelet aggregation test without addition of agents normally used to induce aggregation." ; oboInOwl:hasDbXref "MSH:C566800", "UMLS:C1868263" ; a owl:Class ; rdfs:label "Spontaneous platelet aggregation" ; rdfs:subClassOf obo:HP_0030402 . obo:HP_0030404 obo:IAO_0000115 "An endocrine tumor of the pancreas that secretes excessive amounts of glucagon." ; oboInOwl:hasDbXref "MSH:D005935", "SNOMEDCT_US:128855009", "SNOMEDCT_US:16424000", "SNOMEDCT_US:302823005", "UMLS:C0017689" ; a owl:Class ; rdfs:comment "The excessive glucagon secreted by a glucagonoma may lead to dermatitis (migratory necrolytic erythema), glucose intolerance, weight loss, anemia, diarrhea, and thromboembolism." ; rdfs:label "Glucagonoma" ; rdfs:subClassOf obo:HP_0030405 . obo:HP_0030405 obo:IAO_0000115 "A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas." ; oboInOwl:hasDbXref "MSH:D007516", "SNOMEDCT_US:126864006", "SNOMEDCT_US:128878003", "SNOMEDCT_US:237596009", "SNOMEDCT_US:399528006", "SNOMEDCT_US:76345009", "UMLS:C0242363" ; oboInOwl:hasExactSynonym "Pancreatic endocrine tumour" ; a owl:Class ; rdfs:label "Pancreatic endocrine tumor" ; rdfs:subClassOf obo:HP_0100634 . obo:HP_0030406 obo:IAO_0000115 "A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum." ; oboInOwl:hasDbXref "UMLS:C1514428" ; a owl:Class ; rdfs:label "Primary peritoneal carcinoma" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0030407 obo:IAO_0000115 "A type of pineal parenchymal cell neoplasm that is a mature well-differentiated tumor (WHO grade I)." ; oboInOwl:hasDbXref "MSH:D010871", "NCIT:C6966", "SNOMEDCT_US:255045009", "SNOMEDCT_US:89096009", "UMLS:C0917890" ; a owl:Class ; rdfs:label "Pineocytoma" ; rdfs:subClassOf obo:HP_0030694 . obo:HP_0030408 obo:IAO_0000115 "Pineoblastoma is a rare primitive neuroectodermal tumor (PNET) arising in the pineal gland. Pineoblastomas are classified as a WHO grade IV tumor and comprise one-fourth to one-half of pineal parenchymal tumors. Pineoblastoma is a highly cellular tumor originating in the pineal gland and containing small, poorly differentiated cells." ; oboInOwl:hasAlternativeId "HP:0040193" ; oboInOwl:hasDbXref "MSH:D010871", "SNOMEDCT_US:31671006", "UMLS:C0205898" ; oboInOwl:hasExactSynonym "Pinealoblastoma" ; a owl:Class ; rdfs:comment "Pineoblastomas are rare, malignant, pineal region lesions that account for <0.1% of all intracranial tumors. Pineoblastomas harbor a poor prognosis and can metastasize along the neuroaxis. Although they typically appear radiographically as a focal enhancing mass, pineoblastomas can be locally invasive and spread outside the pineal region through the subarachnoid space. Pineoblastomas are more common in children than in adults, and adults account for <10% of patients." ; rdfs:label "Pineoblastoma" ; rdfs:subClassOf obo:HP_0030694 . obo:HP_0030409 obo:IAO_0000115 "A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice." ; oboInOwl:hasDbXref "SNOMEDCT_US:408642003", "UMLS:C1319314" ; oboInOwl:hasExactSynonym "Renal urothelial carcinoma", "Transitional renal cell carcinoma", "renal TCC" ; a owl:Class ; rdfs:label "Renal transitional cell carcinoma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0030410 obo:IAO_0000115 "A carcinoma that arises in a sebaseous gland (an exocrine gland of the skin that secretes sebum, a waxy substance)" ; oboInOwl:hasDbXref "MSH:D018266", "SNOMEDCT_US:307599002", "SNOMEDCT_US:54734006", "UMLS:C0206684" ; oboInOwl:hasExactSynonym "Sebaceous carcinoma" ; a owl:Class ; rdfs:label "Sebaceous gland carcinoma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0030411 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the jejunum." ; oboInOwl:hasDbXref "NCIT:C2852", "UMLS:C4072935" ; oboInOwl:id "HP:0030411" ; a owl:Class ; rdfs:label "Jejunal adenocarcinoma" ; rdfs:subClassOf obo:HP_0040274 . obo:HP_0030412 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the ileum." ; oboInOwl:hasDbXref "NCIT:C2852", "UMLS:C4072936" ; a owl:Class ; rdfs:label "Ileal adenocarcinoma" ; rdfs:subClassOf obo:HP_0040274 . obo:HP_0030413 obo:IAO_0000115 "A carcinoma derived from a squamous epithelial cell of the tongue." ; oboInOwl:hasDbXref "SNOMEDCT_US:276952000", "UMLS:C0349566" ; a owl:Class ; rdfs:comment "Squamous cell carcinoma of the tongue is often painless and may present as a non-healing ulcer that demonstrates growth over time." ; rdfs:label "Squamous cell carcinoma of the tongue" ; rdfs:subClassOf obo:HP_0100648 . obo:HP_0030414 obo:IAO_0000115 "A low-grade variant of squamous cell carcinoma of the tongue with a warty (verrucous) appearance." ; oboInOwl:hasDbXref "UMLS:C4072937" ; a owl:Class ; rdfs:label "Verrucous cell carcinoma of the tongue" ; rdfs:subClassOf obo:HP_0030413 . obo:HP_0030415 obo:IAO_0000115 "Sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation." ; oboInOwl:hasDbXref "UMLS:C2018408" ; oboInOwl:hasExactSynonym "Spindle cell carcinoma of the tongue" ; a owl:Class ; rdfs:label "Sarcomatoid carcinoma of the tongue" ; rdfs:subClassOf obo:HP_0030413 . obo:HP_0030416 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the female external genital tract (vulva)." ; oboInOwl:hasDbXref "MSH:D014846", "NCIT:C3262", "SNOMEDCT_US:126922007", "UMLS:C0042995" ; oboInOwl:hasExactSynonym "Neoplasm of the vulva", "Tumor of the vulva", "Tumour of the vulva" ; a owl:Class ; rdfs:label "Vulvar neoplasm" ; rdfs:subClassOf obo:HP_0033020 . obo:HP_0030417 obo:IAO_0000115 "A cancer that originates in the squamous cells that line the surface of the vulva." ; oboInOwl:hasDbXref "SNOMEDCT_US:254895003", "UMLS:C0280856" ; oboInOwl:hasExactSynonym "Vulval squamous cell carcinoma" ; a owl:Class ; rdfs:label "Squamous cell carcinoma of the vulva" ; rdfs:subClassOf obo:HP_0030416 . obo:HP_0030418 obo:IAO_0000115 "A type of vulvar cancer that originates from melanocytes of the vulva." ; oboInOwl:hasDbXref "SNOMEDCT_US:254896002", "UMLS:C0241989" ; a owl:Class ; rdfs:comment "The first symptoms typically noticed by the patients are bleeding, pruritus, or a mass in the groin. Vulvar melanomas are mostly located at the labia minora." ; rdfs:label "Vulvar melanoma" ; rdfs:subClassOf obo:HP_0030416 . obo:HP_0030419 obo:IAO_0000115 "A cancer arising in a cell of the Bartholin gland, a racemose gland located slightly posterior to the opening of the vagina." ; oboInOwl:hasDbXref "SNOMEDCT_US:276876007", "SNOMEDCT_US:399533005", "UMLS:C0349561" ; a owl:Class ; rdfs:comment "Carcinomas of Bartholin's gland are rare tumors that account for less than 1% of all gynecological malignancies. Two major histological types, squamous cell carcinoma and adenocarcinoma, account for 80% to 90% of primary cases. The remainder are adenoid-cystic, transitional, or undifferentiated carcinomas." ; rdfs:label "Bartholin gland carcinoma" ; rdfs:subClassOf obo:HP_0030416 . obo:HP_0030420 obo:IAO_0000115 "An adenocarcinoma arising in the vulva." ; oboInOwl:hasDbXref "UMLS:C1336975" ; a owl:Class ; rdfs:label "Vulvar adenocarcinoma" ; rdfs:subClassOf obo:HP_0030416 . obo:HP_0030421 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the epididymis, an duct that transports spermatozoa from the testis to the vas deferens." ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:126902008", "UMLS:C0346239" ; a owl:Class ; rdfs:label "Epididymal neoplasm" ; rdfs:subClassOf obo:HP_0010785 . obo:HP_0030422 obo:IAO_0100001 "HP:0009715" ; a owl:Class ; rdfs:label "obsolete Papillary cystadenoma of the epididymis" ; owl:deprecated true . obo:HP_0030423 obo:IAO_0000115 "A closed sac located in the spleen." ; oboInOwl:hasDbXref "SNOMEDCT_US:79040006", "UMLS:C0272407" ; oboInOwl:hasExactSynonym "Cyst on spleen" ; a owl:Class ; rdfs:label "Splenic cyst" ; rdfs:subClassOf obo:HP_0025408 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030424 obo:IAO_0000115 "A smooth, extratesticular, spherical cyst in the head of the epididymis." ; oboInOwl:hasDbXref "MSH:D013088", "SNOMEDCT_US:43077002", "SNOMEDCT_US:49263001", "UMLS:C0037859" ; oboInOwl:hasExactSynonym "Epididymal cysts" ; a owl:Class ; rdfs:comment "Diagnosis of epididymal cyst can be confirmed by scrotal ultrasound. Patients can present with scrotal mass or pain. Epididymal cysts are usually between 3-30 mm in diameter. In some cases they can resolve spontaneously." ; rdfs:label "Epididymal cyst" ; rdfs:subClassOf obo:HP_0009714 . obo:HP_0030425 obo:IAO_0000115 "A cyst of the ovary that exhibits deposition of calcium salts." ; oboInOwl:hasDbXref "UMLS:C4072939" ; a owl:Class ; rdfs:label "Calcified ovarian cyst" ; rdfs:subClassOf obo:HP_0000138 . obo:HP_0030426 obo:IAO_0000115 "A benign central bone tumor composed of fibrous connective tissue within which bone is formed." ; oboInOwl:hasDbXref "MSH:D018214", "SNOMEDCT_US:25603007", "SNOMEDCT_US:302862001", "SNOMEDCT_US:302863006", "SNOMEDCT_US:80699009", "UMLS:C0206640" ; a owl:Class ; rdfs:label "Ossifying fibroma" ; rdfs:subClassOf obo:HP_0010614 . obo:HP_0030427 obo:IAO_0000115 "A benign central bone tumor of the jaw composed of fibrous connective tissue within which bone is formed." ; oboInOwl:hasDbXref "UMLS:C4072940" ; a owl:Class ; rdfs:comment "The mandible is most commonly affected." ; rdfs:label "Ossifying fibroma of the jaw" ; rdfs:subClassOf obo:HP_0030426, obo:HP_0100649 . obo:HP_0030428 obo:IAO_0000115 "A myxoma originating in the skin." ; oboInOwl:hasDbXref "NCIT:C6577", "UMLS:C1333178" ; a owl:Class ; rdfs:comment "Cutaneous myxomas are sharply demarcated nodules of the dermis or subcutis that may occur as solitary lesions or in association with Carney complex. Microscopically, cutaneous myxomas in the Carney complex have sharp circumscription, hypocellularity, abundant myxoid stroma, prominent capillaries and an occasional epithelial component." ; rdfs:label "Cutaneous myxoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0030429 obo:IAO_0000115 "A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity." ; oboInOwl:hasDbXref "SNOMEDCT_US:60392001", "SNOMEDCT_US:716590006", "UMLS:C1367536" ; a owl:Class ; rdfs:label "Juvenile nasopharyngeal angiofibroma" ; rdfs:subClassOf obo:HP_0012288 . obo:HP_0030430 obo:IAO_0000115 "A tumor made up of nerve cells and nerve fibers." ; oboInOwl:hasDbXref "MSH:D009463", "SNOMEDCT_US:25169009", "SNOMEDCT_US:274089002", "SNOMEDCT_US:443892003", "SNOMEDCT_US:84116009", "UMLS:C0027858", "UMLS:C0273482" ; oboInOwl:hasExactSynonym "Nerve tumor", "Nerve tumour", "Pinched nerve" ; a owl:Class ; rdfs:label "Neuroma" ; rdfs:subClassOf obo:HP_0100007 . obo:HP_0030431 obo:IAO_0000115 "A cartilage capped bony outgrowth of a long bone. Osteochondroma arises on the external surface of bone containing a marrow cavity that is continuous with that of the underlying bone." ; oboInOwl:hasDbXref "MSH:D015831", "SNOMEDCT_US:307573009", "SNOMEDCT_US:443093007", "SNOMEDCT_US:52299001", "UMLS:C0029423" ; oboInOwl:hasExactSynonym "Osteocartilaginous exostoses", "Osteochondromas" ; a owl:Class ; rdfs:label "Osteochondroma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0030432 obo:IAO_0000115 "A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells." ; oboInOwl:hasDbXref "MSH:D002804", "SNOMEDCT_US:9001003", "UMLS:C0008441" ; a owl:Class ; rdfs:comment "Chondroblastomas of bone are rare benign bone tumors, arising at the cartilaginous growth plate, representing approximately 1-2% of all bone tumors. The most common sites are the proximal humerus and the proximal tibia, but the third most common site is the proximal femur. Histologically, the tumor consists predominantly of well-defined polygonal chondroblast-type cells similar to epiphyseal chondrocytes, with large nucleoli and benign-looking nuclei that have a tendency to be multilobulate and have a continuous dense band of substance along the inner nuclear membrane, intra-cytoplasmic inclusions of glycogen and lipids, numerous mitochondria and superficial secretion vesicles arising from a well developed rough endoplasmic reticulum. There are multi-nucleated giant cells, foci of chondroid matrix, with focal calcification that may acquire a \"chicken wire\" appearance. Aneurysmal bone cysts are associated with chondroblastoma in 14% of cases." ; rdfs:label "Chondroblastoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0030433 obo:IAO_0000115 "A bening tumor of bone composed of a central zone named nidus which is an atypical bone completely enclosed within a well vascularized stroma and a peripheral sclerotic reaction zone." ; oboInOwl:hasDbXref "MSH:D010017", "SNOMEDCT_US:302859004", "SNOMEDCT_US:71666005", "UMLS:C0029441" ; a owl:Class ; rdfs:label "Osteoid osteoma" ; rdfs:subClassOf obo:HP_0100246 . obo:HP_0030434 obo:IAO_0000115 "Pilomatricoma is an asymptomatic slowly growing benign cutaneous tumor, differentiating towards the hair matrix of the hair follicle. It is covered by normal or hyperemic skin, and usually varies in size from 0.5 to 3 cm." ; oboInOwl:hasDbXref "MSH:D018296", "SNOMEDCT_US:274901004", "SNOMEDCT_US:44155009", "UMLS:C0206711" ; a owl:Class ; rdfs:comment "Pilomatricomas usually are asymptomatic (pain appears only with associated inflammation and ulceration); deeply seated, firm, nontender subcutaneous masses adherent to the skin but not fixed to the underlying tissue. Stretching of the skin over the tumor shows the \"tent sign\" with multiple facets and angles, a pathognomonic sign for pilomatricoma. In addition, pressing on one edge of the lesion causes the opposite edge to protrude from the skin like a \"teeter-totter\". Both these \"tent sign\" and \"teeter-totter sign\" are the most helpful clinical clues to the diagnosis of pilomatricoma." ; rdfs:label "Pilomatrixoma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0030436 obo:IAO_0000115 "Fibrofolliculoma is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions in adults in different areas such as the scalp, forehead, face, and neck. According to histology, the lesion is a fibrotic hamartoma characterized by infundibular epithelial proliferation and perifollicular fibrous proliferation." ; oboInOwl:hasDbXref "SNOMEDCT_US:128683008", "SNOMEDCT_US:254699007", "UMLS:C0346011" ; oboInOwl:hasExactSynonym "Fibrofolliculomas" ; a owl:Class ; rdfs:label "Fibrofolliculoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0030437 oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:126850006", "UMLS:C0345883" ; oboInOwl:hasExactSynonym "Anal canal tumor", "Anal canal tumour" ; a owl:Class ; rdfs:label "Anal canal neoplasm" ; rdfs:subClassOf obo:HP_0032186, obo:HP_0100834 . obo:HP_0030438 obo:IAO_0000115 "A squamous cell carcinoma that originates in the anal canal." ; oboInOwl:hasDbXref "UMLS:C1332262" ; a owl:Class ; rdfs:comment "Patients typically present with bright red bleeding, pain, and/or a palpable mass. When a clinically suspicious lesion is identified, diagnosis relies on cytologic or histologic confirmation." ; rdfs:label "Anal canal squamous cell carcinoma" ; rdfs:subClassOf obo:HP_0030437 . obo:HP_0030439 obo:IAO_0000115 "An adenoma carcinoma that originates in the anal canal." ; oboInOwl:hasDbXref "NCIT:C2852", "UMLS:C1332259" ; a owl:Class ; rdfs:comment "Differentiating true anal canal adenocarcinoma from low rectal adenocarcinoma can be challenging. Most anal canal adenocarcinomas originate from anal glands, but cases developing in chronic tracts from fistula in ano are described. Multiple factors, including infection with HPV and HIV, history of receptive anal intercourse, smoking, and immunosuppression have been identified as risk factors. Clinical features include anal pain, induration of the anal canal, or abscess formation and a palpable lump." ; rdfs:label "Anal canal adenocarcinoma" ; rdfs:subClassOf obo:HP_0030437, obo:HP_0040275 . obo:HP_0030440 obo:IAO_0000115 "A tumor of the anal margin." ; oboInOwl:hasDbXref "UMLS:C2064234" ; a owl:Class ; rdfs:comment "The anal canal is defined as the caudal part of the large intestine extending from the anorectal ring to the anal verge and is about 3 to 5 cm in length. Outside of the anal verge lies the anal margin, also referred to as the perianal skin, which commonly encompasses a radius of 5 cm. The anal verge can be identified visually as the part of the anal canal remaining closed when the buttocks are gently retracted. The upper anal canal is lined by columnar tissue that transitions into squamous epithelium at the dentate line. The dentate line, identified by the termination of the anal columns, lies 1 to 2 cm above the anal verge." ; rdfs:label "Anal margin neoplasm" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0030441 obo:IAO_0000115 "An intraepithelial adenocarcinoma originating in the anal margin and characterized by presence of typical Paget's cells, appearing as large rounded vacuolated cells." ; oboInOwl:hasDbXref "UMLS:C1332270" ; a owl:Class ; rdfs:comment "Macroscopically, anal margin Paget's disease presents as an erythematous and eczematous rash similar to benign skin conditions or other perianal diseases such as Bowen's disease, hydradenitis suppurativa, pruritus ani, or Crohn's disease." ; rdfs:label "Anal margin Paget's disease" ; rdfs:subClassOf obo:HP_0030440 . obo:HP_0030442 obo:IAO_0000115 "A squamous cell carcinoma that originates in the skin of the anal margin." ; oboInOwl:hasDbXref "SNOMEDCT_US:255084004", "UMLS:C1412037" ; a owl:Class ; rdfs:comment "Clinical presentations include pain, bleeding, palpable lump, and discharge. Typically, SCC of the anal margin appears as an ulcerated lesion with rolled everted edges. A significant number of patients are misdiagnosed with an anal fissure, fistula, eczema, or hemorrhoids; therefore a biopsy is recommended for any persistent anal margin lesion not responding to conservative therapy." ; rdfs:label "Anal margin squamous cell carcinoma" ; rdfs:subClassOf obo:HP_0030440 . obo:HP_0030443 obo:IAO_0000115 "A basal cell carcinoma that originates in the anal margin." ; oboInOwl:hasDbXref "UMLS:C1332269" ; a owl:Class ; rdfs:label "Anal margin basal cell carcinoma" ; rdfs:subClassOf obo:HP_0030440 . obo:HP_0030444 obo:IAO_0000115 "A melanoma that originates in the anal margin." ; oboInOwl:hasDbXref "UMLS:C4072941" ; a owl:Class ; rdfs:label "Anal margin melanoma" ; rdfs:subClassOf obo:HP_0030440 . obo:HP_0030445 obo:IAO_0000115 "A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma." ; oboInOwl:hasDbXref "SNOMEDCT_US:254627002", "UMLS:C0280089" ; oboInOwl:hasExactSynonym "Lung carcinoid tumor", "Lung carcinoid tumour", "Pulmonary carcinoid tumour" ; a owl:Class ; rdfs:label "Pulmonary carcinoid tumor" ; rdfs:subClassOf obo:HP_0100570 . obo:HP_0030446 oboInOwl:hasDbXref "UMLS:C4072942" ; oboInOwl:hasExactSynonym "Atypical pulmonary carcinoid tumour" ; a owl:Class ; rdfs:label "Atypical pulmonary carcinoid tumor" ; rdfs:subClassOf obo:HP_0030445 . obo:HP_0030447 obo:IAO_0000115 "A malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. Most patients present with rapidly growing, painless, firm, non-tender, dome-shaped red, occasionally ulcerated skin nodules, which have a red or bluish color, measuring up to several centimeters, on predominantly sun-exposed areas of the body. The overlying skin is smooth and shiny, sometimes exhibiting ulcerative, acneiform or telangiectatic features." ; oboInOwl:hasDbXref "MSH:D015266", "SNOMEDCT_US:253001006", "SNOMEDCT_US:254729005", "SNOMEDCT_US:5052009", "UMLS:C0007129" ; oboInOwl:hasExactSynonym "Anaplastic carcinoma of the skin", "Cutaneous APUDoma", "Merkel cell cancer of the skin", "Neuroendocrine carcinoma of the skin", "Neuroendocrine tumor of the skin", "Neuroendocrine tumour of the skin", "Primary small cell carcinoma of the skin", "Primary undifferentiated carcinoma of the skin" ; a owl:Class ; rdfs:label "Merkel cell skin cancer" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0040192 . obo:HP_0030448 obo:IAO_0000115 "A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues." ; oboInOwl:hasDbXref "MSH:D012509", "SNOMEDCT_US:2424003", "SNOMEDCT_US:269469005", "SNOMEDCT_US:424413001", "SNOMEDCT_US:424952003", "UMLS:C1261473" ; oboInOwl:hasExactSynonym "Soft tissue sarcomas" ; a owl:Class ; rdfs:comment "Soft tissue sarcomas can be found in any part of the body but most often originate in the arms or legs. They can also be found in the trunk, head and neck area, internal organs, and in the retroperitoneum." ; rdfs:label "Soft tissue sarcoma" ; rdfs:subClassOf obo:HP_0100242 . obo:HP_0030449 obo:IAO_0000115 "Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice." ; oboInOwl:hasDbXref "MSH:D000032", "SNOMEDCT_US:386641000", "UMLS:C0000820" ; a owl:Class ; rdfs:label "Therapeutic abortion" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0030450 obo:IAO_0000115 "A tumor that arises from an element of the autonomic nervous system." ; oboInOwl:hasDbXref "NCIT:C5112", "UMLS:C4072943" ; a owl:Class ; rdfs:label "Neoplasm of the autonomic nervous system" ; rdfs:subClassOf obo:HP_0100007 . obo:HP_0030451 obo:IAO_0000115 "A closed fluid filled sac originating from the mesentary." ; oboInOwl:hasDbXref "MSH:D008639", "SNOMEDCT_US:253802003", "SNOMEDCT_US:27970007", "UMLS:C0025467" ; a owl:Class ; rdfs:comment "A mesenteric cyst is defined as any cyst located in the mesentery; it may or may not extend into the retroperitoneum, which has a recognizable lining of endothelium or mesothelial cell. Mesenteric cyst can occur anywhere in the mesentery of gastrointestinal tract from duodenum to rectum. Mesenteric cysts can be simple or multiple, unilocular or multilocular, and they may contain hemorrhagic, serous, chylous, or infected fluid. They can range in size from a few millimetres to few cm in diameter, however, at times may be so large that it may mimic tubercular ascites." ; rdfs:label "Mesenteric cyst" ; rdfs:subClassOf obo:HP_0100016 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030452 obo:IAO_0000115 "A type of mesenteric cyst that is lined with a thin endothelium or mesothelium and filled with chylous and lymphatic fluid." ; oboInOwl:hasDbXref "UMLS:C4072944" ; a owl:Class ; rdfs:label "Chylolymphatic mesenteric cyst" ; rdfs:subClassOf obo:HP_0030451 . obo:HP_0030453 oboInOwl:hasDbXref "UMLS:C4072945" ; a owl:Class ; rdfs:label "Abnormal visual electrophysiology" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0030454 obo:IAO_0000115 "The clinical electro-oculogram (EOG) is an electrophysiological test of function of the outer retina and retinal pigment epithelium (RPE) in which changes in electrical potential across the RPE are recorded during successive periods of dark and light adaptation." ; oboInOwl:hasDbXref "SNOMEDCT_US:442770004", "UMLS:C0159104" ; oboInOwl:hasExactSynonym "Abnormal EOG" ; a owl:Class ; rdfs:label "Abnormal electrooculogram" ; rdfs:subClassOf obo:HP_0030453 . obo:HP_0030455 oboInOwl:hasDbXref "UMLS:C4072946" ; a owl:Class ; rdfs:label "Abnormality of pattern visual evoked potentials" ; rdfs:subClassOf obo:HP_0000649 . obo:HP_0030456 oboInOwl:hasDbXref "UMLS:C4072947" ; oboInOwl:hasExactSynonym "Abnormality of pattern onset/offset VEP" ; a owl:Class ; rdfs:label "Abnormality of pattern onset/offset visual evoked potentials" ; rdfs:subClassOf obo:HP_0030455 . obo:HP_0030457 oboInOwl:hasDbXref "UMLS:C4072948" ; oboInOwl:hasExactSynonym "Abnormal amplitude of pattern onset/offset VEP" ; a owl:Class ; rdfs:label "Abnormal amplitude of pattern onset/offset visual evoked potentials" ; rdfs:subClassOf obo:HP_0030456 . obo:HP_0030458 oboInOwl:hasDbXref "UMLS:C4072949" ; a owl:Class ; rdfs:label "Abnormal timing of pattern onset/offset visual evoked potentials" ; rdfs:subClassOf obo:HP_0030456 . obo:HP_0030460 oboInOwl:hasDbXref "UMLS:C4072950" ; a owl:Class ; rdfs:label "Abnormal timing of pattern reversal visual evoked potentials" ; rdfs:subClassOf obo:HP_0100289 . obo:HP_0030461 oboInOwl:hasDbXref "UMLS:C4072951" ; a owl:Class ; rdfs:label "Abnormal timing of flash visual evoked potentials" ; rdfs:subClassOf obo:HP_0007928 . obo:HP_0030462 oboInOwl:hasDbXref "UMLS:C4072952" ; a owl:Class ; rdfs:label "Abnormal amplitude of flash visual evoked potentials" ; rdfs:subClassOf obo:HP_0007928 . obo:HP_0030463 oboInOwl:hasDbXref "UMLS:C4072953" ; oboInOwl:hasExactSynonym "Crossed asymmetry of flash visual evoked potentials" ; a owl:Class ; rdfs:label "Asymmetrical distribution of flash visual evoked potentials" ; rdfs:subClassOf obo:HP_0007928 . obo:HP_0030464 oboInOwl:hasDbXref "UMLS:C4072954" ; oboInOwl:hasExactSynonym "Crossed asymmetry of pattern reversal visual evoked potentials" ; a owl:Class ; rdfs:label "Asymmetrical distribution of pattern reversal visual evoked potentials" ; rdfs:subClassOf obo:HP_0100289 . obo:HP_0030465 obo:IAO_0000115 "No detectable response to the light-adapted 3.0 ERG (single-flash cone response). This type of ERG measures responses of the cone system; a-waves arise from cone photoreceptors and cone off-bipolar cells; the b-wave comes from On- and Off-cone bipolar cells." ; oboInOwl:hasDbXref "UMLS:C4072955" ; oboInOwl:hasExactSynonym "Absent photopic (cone) responses on ERG", "non-detectable photopic ERG" ; a owl:Class ; rdfs:label "Undetectable light-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0008275 . obo:HP_0030466 oboInOwl:hasDbXref "UMLS:C4072956" ; a owl:Class ; rdfs:label "Abnormal full-field electroretinogram" ; rdfs:subClassOf obo:HP_0000512 . obo:HP_0030467 obo:IAO_0000115 "An anomalous response to a pattern electroretinogram (PERG), a particular kind of ERG obtained in response to contrast modulation of patterned visual stimuli at constant mean luminance-typically contrast-reversing gratings or checkerboards-whose characteristics are fundamentally different from those of the traditional ERG in response to diffuse flashes of light." ; oboInOwl:hasDbXref "UMLS:C4072957" ; a owl:Class ; rdfs:label "Abnormal pattern electroretinogram" ; rdfs:subClassOf obo:HP_0000512 . obo:HP_0030468 oboInOwl:hasDbXref "UMLS:C4072958" ; a owl:Class ; rdfs:label "Abnormal multifocal electroretinogram" ; rdfs:subClassOf obo:HP_0000512 . obo:HP_0030469 oboInOwl:hasDbXref "UMLS:C4072959" ; a owl:Class ; rdfs:label "Abnormal dark-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0030466 . obo:HP_0030470 oboInOwl:hasDbXref "UMLS:C4072960" ; a owl:Class ; rdfs:label "Abnormal dark-adapted bright flash electroretinogram" ; rdfs:subClassOf obo:HP_0030469 . obo:HP_0030471 oboInOwl:hasDbXref "UMLS:C4072961" ; a owl:Class ; rdfs:label "Abnormal dark-adapted dim flash electroretinogram" ; rdfs:subClassOf obo:HP_0030469 . obo:HP_0030472 oboInOwl:hasDbXref "UMLS:C4072962" ; a owl:Class ; rdfs:label "Abnormal light-adapted single flash electroretinogram" ; rdfs:subClassOf obo:HP_0008275 . obo:HP_0030473 oboInOwl:hasDbXref "UMLS:C4072963" ; oboInOwl:hasExactSynonym "Abnormal light adapted flicker electroretinogram", "Abnormal light-adapted 30Hz flicker ERG", "Abnormal light-adapted 30Hz flicker electroretinogram", "Abnormal light-adapted flicker ERG" ; a owl:Class ; rdfs:label "Abnormal light-adapted flicker electroretinogram" ; rdfs:subClassOf obo:HP_0008275 . obo:HP_0030474 oboInOwl:hasDbXref "UMLS:C4072964" ; a owl:Class ; rdfs:label "Undetectable dark-adapted electroretinogram" ; rdfs:subClassOf obo:HP_0030469 . obo:HP_0030475 oboInOwl:hasDbXref "UMLS:C4072965" ; a owl:Class ; rdfs:label "Abnormal timing of dark-adapted dim flash electroretinogram" ; rdfs:subClassOf obo:HP_0030471 . obo:HP_0030476 oboInOwl:hasDbXref "UMLS:C4072966" ; a owl:Class ; rdfs:label "Abnormal amplitude of dark-adapted dim flash electroretinogram" ; rdfs:subClassOf obo:HP_0030471 . obo:HP_0030477 oboInOwl:hasDbXref "UMLS:C4072967" ; a owl:Class ; rdfs:label "Abnormal timing of dark-adapted bright flash electroretinogram" ; rdfs:subClassOf obo:HP_0030470 . obo:HP_0030478 oboInOwl:hasDbXref "UMLS:C4072968" ; a owl:Class ; rdfs:label "Abnormal amplitude of dark-adapted bright flash electroretinogram" ; rdfs:subClassOf obo:HP_0030470 . obo:HP_0030479 oboInOwl:hasDbXref "UMLS:C4072969" ; a owl:Class ; rdfs:label "Abnormal amplitude of light-adapted flicker electroretinogram" ; rdfs:subClassOf obo:HP_0030473 . obo:HP_0030480 oboInOwl:hasDbXref "UMLS:C4072970" ; a owl:Class ; rdfs:label "Abnormal timing of light-adapted flicker electroretinogram" ; rdfs:subClassOf obo:HP_0030473 . obo:HP_0030481 oboInOwl:hasDbXref "UMLS:C4072971" ; a owl:Class ; rdfs:label "Abnormal amplitude of light-adapted single flash electroretinogram" ; rdfs:subClassOf obo:HP_0030472 . obo:HP_0030482 oboInOwl:hasDbXref "UMLS:C4072972" ; a owl:Class ; rdfs:label "Abnormal timing of light-adapted single flash electroretinogram" ; rdfs:subClassOf obo:HP_0030472 . obo:HP_0030483 obo:IAO_0000115 "An abnormal reduction in the amplitude of the a-wave." ; oboInOwl:hasDbXref "UMLS:C4072973" ; a owl:Class ; rdfs:label "Reduced amplitude of dark-adapted bright flash electroretinogram a-wave" ; rdfs:subClassOf obo:HP_0030478 . obo:HP_0030484 oboInOwl:hasDbXref "UMLS:C4072974" ; a owl:Class ; rdfs:label "Supernormal dark-adapted bright flash electroretinogram b-wave" ; rdfs:subClassOf obo:HP_0030478 . obo:HP_0030485 oboInOwl:hasDbXref "UMLS:C4072975" ; a owl:Class ; rdfs:label "Abnormal amplitude of pattern electroretinogram" ; rdfs:subClassOf obo:HP_0030467 . obo:HP_0030486 oboInOwl:hasDbXref "UMLS:C4072976" ; a owl:Class ; rdfs:label "Abnormal timing of pattern electroretinogram" ; rdfs:subClassOf obo:HP_0030467 . obo:HP_0030487 oboInOwl:hasDbXref "UMLS:C4072977" ; a owl:Class ; rdfs:label "Abnormal P50/N95 ratio of pattern electroretinogram" ; rdfs:subClassOf obo:HP_0030467 . obo:HP_0030488 oboInOwl:hasDbXref "UMLS:C4072978" ; a owl:Class ; rdfs:label "Abnormal central response of multifocal electroretinogram" ; rdfs:subClassOf obo:HP_0030468 . obo:HP_0030489 oboInOwl:hasDbXref "UMLS:C4072979" ; a owl:Class ; rdfs:label "Abnormal paracentral response of multifocal electroretinogram" ; rdfs:subClassOf obo:HP_0030468 . obo:HP_0030490 oboInOwl:hasDbXref "UMLS:C4072980" ; a owl:Class ; rdfs:label "Exudative vitreoretinopathy" ; rdfs:subClassOf obo:HP_0007773 . obo:HP_0030491 obo:IAO_0000115 "Atrophy of the capillary lamina of choroid." ; oboInOwl:hasDbXref "UMLS:C3275758" ; a owl:Class ; rdfs:label "Choriocapillaris atrophy" ; rdfs:subClassOf obo:HP_0000533 . obo:HP_0030493 obo:IAO_0000115 "An anomaly of the pigmentation in the fovea centralis." ; oboInOwl:hasDbXref "UMLS:C4072981" ; a owl:Class ; rdfs:label "Abnormality of foveal pigmentation" ; rdfs:subClassOf obo:HP_0000493, obo:HP_0008002 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001786 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030494 obo:IAO_0000115 "Small, red dots in the superficial retinal layers (it is difficult to distinguish between small hemorrhages and microaneurysms)." ; oboInOwl:hasDbXref "UMLS:C4072982" ; a owl:Class ; rdfs:label "Macular microaneurysm/hemorrhage" ; rdfs:subClassOf obo:HP_0030495, obo:HP_0032416 . obo:HP_0030495 obo:IAO_0000115 "Any structural anomaly of the blood vessels of the macula." ; oboInOwl:hasDbXref "UMLS:C4072983" ; oboInOwl:hasExactSynonym "Abnormality of macular vasculature" ; a owl:Class ; rdfs:label "Abnormality morphology of the macular vasculature" ; rdfs:subClassOf obo:HP_0001103 . obo:HP_0030496 obo:IAO_0000115 "Yellow-white intraretinal deposits in the macula typically associated with damaged outer blood-retina barrier and exudation of serous fluid and lipids from the retinal microvasculature." ; oboInOwl:hasDbXref "UMLS:C4072984" ; oboInOwl:hasExactSynonym "Macular exudates", "Macular exudation" ; a owl:Class ; rdfs:label "Macular exudate" ; rdfs:subClassOf obo:HP_0030495 . obo:HP_0030497 obo:IAO_0000115 "Fluffy white patch on the macula, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels." ; oboInOwl:hasDbXref "UMLS:C4072985" ; a owl:Class ; rdfs:comment "Cotton-wool spots (CWSs) are common retinal manifestations of many diseases including diabetes mellitus, systemic hypertension, and acquired immunodeficiency syndrome." ; rdfs:label "Macular cotton wool spot" ; rdfs:subClassOf obo:HP_0030500, obo:HP_0031606 . obo:HP_0030498 obo:IAO_0000115 "Abnormal increase in retinal thickness in the macular area observed on fundoscopy or fundus imaging." ; oboInOwl:hasDbXref "UMLS:C4072986" ; a owl:Class ; rdfs:label "Macular thickening" ; rdfs:subClassOf obo:HP_0001103 . obo:HP_0030499 obo:IAO_0000115 "Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye. This class refers to the presence of Drusen in the macula." ; oboInOwl:hasDbXref "SNOMEDCT_US:247154004", "UMLS:C0677628" ; oboInOwl:hasRelatedSynonym "Lipid accumulation in macula" ; a owl:Class ; rdfs:label "Macular drusen" ; rdfs:subClassOf obo:HP_0011510, obo:HP_0030500 . obo:HP_0030500 oboInOwl:hasDbXref "UMLS:C4072987" ; a owl:Class ; rdfs:label "Yellow/white lesions of the macula" ; rdfs:subClassOf obo:HP_0001103, obo:HP_0030506 . obo:HP_0030501 obo:IAO_0000115 "Crystalline deposits in the macula." ; oboInOwl:hasDbXref "UMLS:C4072988" ; a owl:Class ; rdfs:label "Macular crystals" ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0030502 obo:IAO_0000115 "Splitting of the neuroretinal layers of the retina." ; oboInOwl:hasDbXref "MSH:D041441", "SNOMEDCT_US:44268007", "UMLS:C0152439" ; a owl:Class ; rdfs:label "Retinoschisis" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0030503 oboInOwl:hasDbXref "SNOMEDCT_US:232024000", "UMLS:C0339480" ; oboInOwl:hasExactSynonym "Juxtafoveal telangiectasia", "Parafoveal telangiectasia" ; a owl:Class ; rdfs:label "Macular telangiectasia" ; rdfs:subClassOf obo:HP_0007763, obo:HP_0030495 . obo:HP_0030504 oboInOwl:hasDbXref "UMLS:C4072989" ; oboInOwl:hasExactSynonym "Bear track congenital hypertrophy of retinal pigment epithelium" ; a owl:Class ; rdfs:label "Grouped congenital hypertrophy of retinal pigment epithelium" ; rdfs:subClassOf obo:HP_0007649 . obo:HP_0030505 obo:IAO_0000115 "Clumped pigmentary changes of nummular appearance (i.e., thought to resemble the shape of a coin or multiple coins stuck together) at the level of the retinal pigment epithelium." ; oboInOwl:hasDbXref "UMLS:C4072990" ; oboInOwl:hasExactSynonym "Nummular pigmentation of the retina" ; a owl:Class ; rdfs:label "Nummular pigmentation of the fundus" ; rdfs:subClassOf obo:HP_0000580 . obo:HP_0030506 oboInOwl:hasDbXref "UMLS:C4072991" ; a owl:Class ; rdfs:label "Yellow/white lesions of the retina" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0030507 obo:IAO_0000115 "Crystalline deposits in the retina." ; oboInOwl:hasDbXref "UMLS:C4072992" ; a owl:Class ; rdfs:comment "Crystalline deposits in the retina may be associated with a wide variety of systemic disorders such as oxalosis, cystinosis, hyperornithinaemia and Sjogren-Larsson syndrome. Refractile crystalline deposits may also be a manifestation of drug toxicity like the antineoplastic agent tamoxifen, the anesthetic methoxyflurane and the oral tanning agent canthaxanthine. Crystals may also occur in drug abusers who inject multiple crushed tablets of methadone or meperidine intravenously (talc retinopathy)." ; rdfs:label "Retinal crystals" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0030508 oboInOwl:hasDbXref "SNOMEDCT_US:312937006", "UMLS:C0730304" ; oboInOwl:hasExactSynonym "Retinal cavernous haemangioma" ; a owl:Class ; rdfs:label "Retinal cavernous hemangioma" ; rdfs:subClassOf obo:HP_0009594 . obo:HP_0030509 oboInOwl:hasDbXref "UMLS:C4072993" ; oboInOwl:hasExactSynonym "Retinal racemose haemangioma" ; a owl:Class ; rdfs:label "Retinal racemose hemangioma" ; rdfs:subClassOf obo:HP_0009594 . obo:HP_0030510 oboInOwl:hasDbXref "UMLS:C1862062" ; a owl:Class ; rdfs:label "Combined hamartoma of the retinal pigment epithelium and retina" ; rdfs:subClassOf obo:HP_0009594 . obo:HP_0030511 obo:IAO_0000115 "Difficulty in seeing moving objects." ; oboInOwl:hasDbXref "MSH:C564243", "SNOMEDCT_US:711163009", "UMLS:C1842073" ; oboInOwl:hasExactSynonym "Difficulty seeing moving objects" ; a owl:Class ; rdfs:label "Bradyopsia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0030512 oboInOwl:hasDbXref "UMLS:C4072994" ; a owl:Class ; rdfs:label "Difficulty adjusting to changes in luminance" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0030513 oboInOwl:hasDbXref "UMLS:C4072995" ; a owl:Class ; rdfs:label "Difficulty adjusting from light to dark" ; rdfs:subClassOf obo:HP_0030512 . obo:HP_0030514 oboInOwl:hasDbXref "UMLS:C4072996" ; a owl:Class ; rdfs:label "Difficulty adjusting from dark to light" ; rdfs:subClassOf obo:HP_0030512 . obo:HP_0030515 obo:IAO_0000115 "Moderate reduction of the ability to see defined as visual acuity less than 6/18 (20/60 in US notation; 0.5 in decimal notation) but at least 6/60 (20/200 in US notation; 0.1 in decimal notation)." ; oboInOwl:hasDbXref "SNOMEDCT_US:397542006", "UMLS:C1301510" ; oboInOwl:hasExactSynonym "Moderate reduction in visual acuity", "Moderate vision loss", "Moderate visual impairment", "Moderate visual loss" ; a owl:Class ; rdfs:label "Moderately reduced visual acuity" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0030516 oboInOwl:hasDbXref "MSH:D006423", "SNOMEDCT_US:34063005", "UMLS:C0271202" ; oboInOwl:hasExactSynonym "Homonymous hemianopsia" ; a owl:Class ; rdfs:label "Homonymous hemianopia" ; rdfs:subClassOf obo:HP_0012377 . obo:HP_0030517 oboInOwl:hasDbXref "SNOMEDCT_US:344104004", "SNOMEDCT_US:345121001", "UMLS:C0271207" ; oboInOwl:hasExactSynonym "Heteronymous hemianopsia" ; a owl:Class ; rdfs:label "Heteronymous hemianopia" ; rdfs:subClassOf obo:HP_0012377 . obo:HP_0030518 oboInOwl:hasDbXref "UMLS:C4072997" ; oboInOwl:hasExactSynonym "Congruous hemianopsia" ; a owl:Class ; rdfs:label "Congruous homonymous hemianopia" ; rdfs:subClassOf obo:HP_0030516 . obo:HP_0030519 oboInOwl:hasDbXref "UMLS:C4072998" ; a owl:Class ; rdfs:label "Congruous heteronymous hemianopia" ; rdfs:subClassOf obo:HP_0030517 . obo:HP_0030520 oboInOwl:hasDbXref "MSH:D006423", "SNOMEDCT_US:87278000", "UMLS:C0271208" ; a owl:Class ; rdfs:label "Binasal hemianopia" ; rdfs:subClassOf obo:HP_0030517 . obo:HP_0030521 oboInOwl:hasDbXref "MSH:D006423", "SNOMEDCT_US:61917005", "UMLS:C0221184" ; a owl:Class ; rdfs:label "Bitemporal hemianopia" ; rdfs:subClassOf obo:HP_0030517 . obo:HP_0030522 obo:IAO_0000115 "A diminution of the peripheral visual field whereby at least 50 degrees of central field are preserved in all meridians." ; oboInOwl:hasDbXref "UMLS:C4072999" ; oboInOwl:hasExactSynonym "Mild peripheral visual field loss" ; a owl:Class ; rdfs:label "Mild constriction of peripheral visual field" ; rdfs:subClassOf obo:HP_0001133 . obo:HP_0030523 obo:IAO_0100001 "HP:0030525" ; a owl:Class ; rdfs:label "obsolete Peripheral visual field constriction with 40-50 degrees central field preserved" ; owl:deprecated true . obo:HP_0030524 obo:IAO_0100001 "HP:0030525" ; a owl:Class ; rdfs:label "obsolete Peripheral visual field constriction with 30-39 degrees central field preserved" ; owl:deprecated true . obo:HP_0030525 obo:IAO_0000115 "Peripheral visual field constriction with 20-49 degrees binocular visual field preserved." ; oboInOwl:hasAlternativeId "HP:0030523", "HP:0030524" ; oboInOwl:hasDbXref "UMLS:C4073002" ; oboInOwl:hasExactSynonym "Moderate peripheral visual field loss" ; a owl:Class ; rdfs:label "Moderate constriction of peripheral visual field" ; rdfs:subClassOf obo:HP_0001133 . obo:HP_0030526 obo:IAO_0000115 "Peripheral visual field constriction with 10-19 degrees central field preserved." ; oboInOwl:hasDbXref "UMLS:C4073003" ; oboInOwl:hasExactSynonym "Severe peripheral visual field loss" ; a owl:Class ; rdfs:label "Severe constriction of peripheral visual field" ; rdfs:subClassOf obo:HP_0001133 . obo:HP_0030527 obo:IAO_0000115 "Peripheral visual field constriction with <10 degrees central field preserved." ; oboInOwl:hasDbXref "UMLS:C4073004" ; oboInOwl:hasExactSynonym "Very severe peripheral visual field loss" ; a owl:Class ; rdfs:label "Very severe constriction of peripheral visual field" ; rdfs:subClassOf obo:HP_0001133 . obo:HP_0030528 oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:64418005", "UMLS:C0271197" ; a owl:Class ; rdfs:label "Paracentral scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0030529 obo:IAO_0000115 "An annular field defect centered on fixation." ; oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:129625005", "UMLS:C0438434" ; oboInOwl:hasExactSynonym "Annular scotoma" ; a owl:Class ; rdfs:comment "See Figures 1 and 3 of PMID:30581310." ; rdfs:label "Ring scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0030530 oboInOwl:hasBroadSynonym "Arc-shaped blind spot" ; oboInOwl:hasDbXref "MSH:D012607", "SNOMEDCT_US:15462009", "UMLS:C0271198", "UMLS:C4280302" ; a owl:Class ; rdfs:label "Arcuate scotoma" ; rdfs:subClassOf obo:HP_0000575 . obo:HP_0030531 oboInOwl:hasDbXref "UMLS:C4073005" ; a owl:Class ; rdfs:label "Altitudinal visual field defect" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0030532 oboInOwl:hasDbXref "UMLS:C4073006" ; a owl:Class ; rdfs:label "Visual acuity test abnormality" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0030533 oboInOwl:hasDbXref "UMLS:C4073007" ; a owl:Class ; rdfs:label "Abnormal unaided visual acuity test" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030534 oboInOwl:hasDbXref "UMLS:C4073008" ; a owl:Class ; rdfs:label "Abnormal best corrected visual acuity test" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030535 oboInOwl:hasDbXref "UMLS:C4073009" ; a owl:Class ; rdfs:label "Abnormal pinhole visual acuity test" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030536 oboInOwl:hasDbXref "UMLS:C4073010" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.1 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030537 oboInOwl:hasDbXref "UMLS:C4073011" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.2 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030538 oboInOwl:hasDbXref "UMLS:C4073012" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.3 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030539 oboInOwl:hasDbXref "UMLS:C4073013" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.4 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030540 oboInOwl:hasDbXref "UMLS:C4073014" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.5 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030541 oboInOwl:hasDbXref "UMLS:C4073015" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.6 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030542 oboInOwl:hasDbXref "UMLS:C4073016" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.7 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030543 oboInOwl:hasDbXref "UMLS:C4073017" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.8 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030544 oboInOwl:hasDbXref "UMLS:C4073018" ; a owl:Class ; rdfs:label "Unaided visual acuity 0.9 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030545 oboInOwl:hasDbXref "UMLS:C4073019" ; a owl:Class ; rdfs:label "Unaided visual acuity 1.0 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030546 oboInOwl:hasDbXref "UMLS:C4073020" ; a owl:Class ; rdfs:label "Unaided visual acuity 1.1 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030547 oboInOwl:hasDbXref "UMLS:C4073021" ; a owl:Class ; rdfs:label "Unaided visual acuity 1.2 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030548 oboInOwl:hasDbXref "UMLS:C4073022" ; a owl:Class ; rdfs:label "Unaided visual acuity 1.3 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030549 oboInOwl:hasDbXref "UMLS:C4073023" ; a owl:Class ; rdfs:label "Unaided visual acuity 2.0 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030550 oboInOwl:hasDbXref "UMLS:C4073024" ; a owl:Class ; rdfs:label "Unaided visual acuity 3.0 LogMAR" ; rdfs:subClassOf obo:HP_0030533 . obo:HP_0030551 oboInOwl:hasDbXref "UMLS:C4073025" ; a owl:Class ; rdfs:label "Visual acuity light perception with projection" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030552 oboInOwl:hasDbXref "UMLS:C4073026" ; a owl:Class ; rdfs:label "Visual acuity light perception without projection" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030553 oboInOwl:hasDbXref "SNOMEDCT_US:63063006", "UMLS:C0442774" ; a owl:Class ; rdfs:label "Visual acuity no light perception" ; rdfs:subClassOf obo:HP_0030532 . obo:HP_0030554 oboInOwl:hasDbXref "UMLS:C4073027" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.1 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030555 oboInOwl:hasDbXref "UMLS:C4073028" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.2 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030556 oboInOwl:hasDbXref "UMLS:C4073029" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.3 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030557 oboInOwl:hasDbXref "UMLS:C4073030" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.4 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030558 oboInOwl:hasDbXref "UMLS:C4073031" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.5 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030559 oboInOwl:hasDbXref "UMLS:C4073032" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.7 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030560 oboInOwl:hasDbXref "UMLS:C4073033" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.6 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030561 oboInOwl:hasDbXref "UMLS:C4073034" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.8 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030562 oboInOwl:hasDbXref "UMLS:C4073035" ; a owl:Class ; rdfs:label "Best corrected visual acuity 0.9 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030563 oboInOwl:hasDbXref "UMLS:C4073036" ; a owl:Class ; rdfs:label "Best corrected visual acuity 1.0 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030564 oboInOwl:hasDbXref "UMLS:C4073037" ; a owl:Class ; rdfs:label "Best corrected visual acuity 1.1 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030565 oboInOwl:hasDbXref "UMLS:C4073038" ; a owl:Class ; rdfs:label "Best corrected visual acuity 1.2 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030566 oboInOwl:hasDbXref "UMLS:C4073039" ; a owl:Class ; rdfs:label "Best corrected visual acuity 1.3 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030567 oboInOwl:hasDbXref "UMLS:C4073040" ; a owl:Class ; rdfs:label "Best corrected visual acuity 2.0 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030568 oboInOwl:hasDbXref "UMLS:C4073041" ; a owl:Class ; rdfs:label "Best corrected visual acuity 3.0 LogMAR" ; rdfs:subClassOf obo:HP_0030534 . obo:HP_0030569 oboInOwl:hasDbXref "UMLS:C4073042" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.1 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030570 oboInOwl:hasDbXref "UMLS:C4073043" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.2 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030571 oboInOwl:hasDbXref "UMLS:C4073044" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.3 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030572 oboInOwl:hasDbXref "UMLS:C4073045" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.4 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030573 oboInOwl:hasDbXref "UMLS:C4073046" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.5 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030574 oboInOwl:hasDbXref "UMLS:C4073047" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.6 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030575 oboInOwl:hasDbXref "UMLS:C4073048" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.7 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030576 oboInOwl:hasDbXref "UMLS:C4073049" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.8 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030577 oboInOwl:hasDbXref "UMLS:C4073050" ; a owl:Class ; rdfs:label "Pinhole visual acuity 0.9 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030578 oboInOwl:hasDbXref "UMLS:C4073051" ; a owl:Class ; rdfs:label "Pinhole visual acuity 1.0 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030579 oboInOwl:hasDbXref "UMLS:C4073052" ; a owl:Class ; rdfs:label "Pinhole visual acuity 1.1 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030580 oboInOwl:hasDbXref "UMLS:C4073053" ; a owl:Class ; rdfs:label "Pinhole visual acuity 1.2 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030581 oboInOwl:hasDbXref "UMLS:C4073054" ; a owl:Class ; rdfs:label "Pinhole visual acuity 1.3 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030582 oboInOwl:hasDbXref "UMLS:C4073055" ; a owl:Class ; rdfs:label "Pinhole visual acuity 2.0 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030583 oboInOwl:hasDbXref "UMLS:C4073056" ; a owl:Class ; rdfs:label "Pinhole visual acuity 3.0 LogMAR" ; rdfs:subClassOf obo:HP_0030535 . obo:HP_0030584 oboInOwl:hasDbXref "UMLS:C4073057" ; oboInOwl:hasExactSynonym "Colour vision test abnormality" ; a owl:Class ; rdfs:label "Color vision test abnormality" ; rdfs:subClassOf obo:HP_0000551 . obo:HP_0030585 oboInOwl:hasDbXref "UMLS:C4073058" ; a owl:Class ; rdfs:label "Red desaturation" ; rdfs:subClassOf obo:HP_0030584 . obo:HP_0030586 oboInOwl:hasDbXref "UMLS:C4073059" ; a owl:Class ; rdfs:label "Abnormal Ishihara plate test" ; rdfs:subClassOf obo:HP_0030584 . obo:HP_0030587 oboInOwl:hasDbXref "UMLS:C4073060" ; a owl:Class ; rdfs:label "Abnormal Hardy-Rand-Rittler plate test" ; rdfs:subClassOf obo:HP_0030584 . obo:HP_0030588 obo:IAO_0000115 "Abnormal result of a test designed to test an individual's central and peripheral vision by determining the ability of the individual to perceive objects at differing locations of the visual field." ; oboInOwl:hasDbXref "UMLS:C0854021" ; a owl:Class ; rdfs:label "Abnormal visual field test" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0030589 oboInOwl:hasDbXref "UMLS:C4073061" ; a owl:Class ; rdfs:label "Abnormal confrontational visual field test" ; rdfs:subClassOf obo:HP_0030588 . obo:HP_0030590 oboInOwl:hasDbXref "UMLS:C4073062" ; a owl:Class ; rdfs:label "Abnormal Amsler grid test" ; rdfs:subClassOf obo:HP_0030588 . obo:HP_0030591 oboInOwl:hasDbXref "UMLS:C4073063" ; a owl:Class ; rdfs:label "Abnormal kinetic perimetry test" ; rdfs:subClassOf obo:HP_0030588 . obo:HP_0030592 oboInOwl:hasDbXref "UMLS:C4073064" ; a owl:Class ; rdfs:label "Abnormal static perimetry test" ; rdfs:subClassOf obo:HP_0030588 . obo:HP_0030593 oboInOwl:hasDbXref "UMLS:C4073065" ; a owl:Class ; rdfs:label "Abnormal manual kinetic perimetry test" ; rdfs:subClassOf obo:HP_0030591 . obo:HP_0030594 oboInOwl:hasDbXref "UMLS:C4073066" ; a owl:Class ; rdfs:label "Abnormal automated kinetic perimetry test" ; rdfs:subClassOf obo:HP_0030591 . obo:HP_0030595 oboInOwl:hasDbXref "UMLS:C4073067" ; a owl:Class ; rdfs:label "Abnormal static automated perimetry test" ; rdfs:subClassOf obo:HP_0030592 . obo:HP_0030596 oboInOwl:hasDbXref "UMLS:C4073068" ; a owl:Class ; rdfs:label "Abnormal Humphrey SITA 30-2 perimetry test" ; rdfs:subClassOf obo:HP_0030595 . obo:HP_0030597 oboInOwl:hasDbXref "UMLS:C4073069" ; a owl:Class ; rdfs:label "Abnormal Humphrey SITA 24-2 perimetry test" ; rdfs:subClassOf obo:HP_0030595 . obo:HP_0030598 oboInOwl:hasDbXref "UMLS:C4073070" ; a owl:Class ; rdfs:label "Abnormal Humphrey SITA 10-2 perimetry test" ; rdfs:subClassOf obo:HP_0030595 . obo:HP_0030599 obo:IAO_0000115 "The Esterman grid test assays scores visual acuity. The grid consists of 100 units whose unequal size and distribution reflect the unequal functional value of different parts of the field-in effect a weighted or relative-value scale. Because each unit equals 1 percent, a simple count of units yields the functional score in percent." ; oboInOwl:hasDbXref "UMLS:C4073071" ; a owl:Class ; rdfs:label "Abnormal Esterman grid perimetry test" ; rdfs:subClassOf obo:HP_0030595 . obo:HP_0030601 oboInOwl:hasDbXref "UMLS:C4073072" ; a owl:Class ; rdfs:label "Abnormal posterior segment imaging" ; rdfs:subClassOf obo:HP_0004329 . obo:HP_0030602 obo:IAO_0000115 "Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference." ; oboInOwl:hasDbXref "UMLS:C4073073" ; a owl:Class ; rdfs:comment "Fundus autofluorescence imagine is used for evaluating age related macular degeneration, macular dystrophies, retinitis pigmentosa, white dot syndromes, retinal drug toxicities, and various other retinal disorders." ; rdfs:label "Abnormal fundus autofluorescence imaging" ; rdfs:subClassOf obo:HP_0030601 . obo:HP_0030603 oboInOwl:hasDbXref "UMLS:C3665728" ; a owl:Class ; rdfs:label "Abnormal optical coherence tomography" ; rdfs:subClassOf obo:HP_0030601 . obo:HP_0030604 obo:IAO_0000115 "An abnormality observed by retinal fluorescein angiography, which involves the intravenous injection of fluorescein dye followed by fluorescent imaging of the fundus immediately after injection and for up to ten minutes thereafter. It can be used to study various retinal abnormalities including especially anomalies of the choroidal and retinal circulation." ; oboInOwl:hasDbXref "UMLS:C4073074" ; a owl:Class ; rdfs:label "Abnormal fundus fluorescein angiography" ; rdfs:subClassOf obo:HP_0030601 . obo:HP_0030605 oboInOwl:hasDbXref "UMLS:C4073075" ; a owl:Class ; rdfs:label "Abnormal indocyanine green angiography" ; rdfs:subClassOf obo:HP_0030601 . obo:HP_0030606 oboInOwl:hasDbXref "UMLS:C4073076" ; a owl:Class ; rdfs:label "Abnormal OCT-measured macular thickness" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030607 oboInOwl:hasDbXref "UMLS:C4073077" ; a owl:Class ; rdfs:label "Reduced OCT-measured macular thickness" ; rdfs:subClassOf obo:HP_0030606 . obo:HP_0030608 oboInOwl:hasDbXref "UMLS:C4073078" ; a owl:Class ; rdfs:label "Increased OCT-measured macular thickness" ; rdfs:subClassOf obo:HP_0030606 . obo:HP_0030609 obo:IAO_0000115 "Loss of the outer nuclear layer (photoreceptor layer) as assessed by ocular coherence tomography." ; oboInOwl:hasDbXref "UMLS:C4073079" ; a owl:Class ; rdfs:label "Photoreceptor layer loss on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030610 oboInOwl:hasDbXref "UMLS:C4073080" ; a owl:Class ; rdfs:label "Photoreceptor outer segment loss on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030611 oboInOwl:hasDbXref "UMLS:C4073081" ; a owl:Class ; rdfs:label "Retinal pigment epithelial loss on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030612 oboInOwl:hasDbXref "UMLS:C4073082" ; a owl:Class ; rdfs:label "Abnormal retinal morphology on macular OCT" ; rdfs:subClassOf obo:HP_0030603 . obo:HP_0030613 oboInOwl:hasDbXref "UMLS:C4073083" ; a owl:Class ; rdfs:label "Abnormal foveal morphology on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030614 oboInOwl:hasDbXref "UMLS:C4073084" ; a owl:Class ; rdfs:label "Foveal photoreceptor layer loss on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030615 oboInOwl:hasDbXref "UMLS:C4073085" ; a owl:Class ; rdfs:label "Foveal photoreceptor outer segment loss on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030616 oboInOwl:hasDbXref "UMLS:C4073086" ; a owl:Class ; rdfs:label "Foveal retinal pigment epithelial loss on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030617 oboInOwl:hasDbXref "UMLS:C4073087" ; a owl:Class ; rdfs:label "Abnormal OCT-measured foveal thickness" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030618 oboInOwl:hasDbXref "UMLS:C4073088" ; a owl:Class ; rdfs:label "Increased OCT-measured foveal thickness" ; rdfs:subClassOf obo:HP_0030617 . obo:HP_0030619 oboInOwl:hasDbXref "UMLS:C4073089" ; a owl:Class ; rdfs:label "Reduced OCT-measured foveal thickness" ; rdfs:subClassOf obo:HP_0030617 . obo:HP_0030620 oboInOwl:hasDbXref "UMLS:C4073090" ; a owl:Class ; rdfs:label "Inner retinal layer loss on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030621 oboInOwl:hasDbXref "UMLS:C4073091" ; a owl:Class ; rdfs:label "Foveal inner retinal layer loss on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030622 oboInOwl:hasDbXref "UMLS:C4073092" ; a owl:Class ; rdfs:label "Abnormal foveal pit on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030623 oboInOwl:hasDbXref "UMLS:C4073093" ; a owl:Class ; rdfs:label "Intraretinal hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030625 . obo:HP_0030624 oboInOwl:hasDbXref "UMLS:C4073094" ; a owl:Class ; rdfs:label "Subretinal hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030625 . obo:HP_0030625 oboInOwl:hasDbXref "UMLS:C4073095" ; a owl:Class ; rdfs:label "Hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030612 . obo:HP_0030626 oboInOwl:hasDbXref "UMLS:C4073096" ; a owl:Class ; rdfs:label "Foveal intraretinal hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030627 . obo:HP_0030627 oboInOwl:hasDbXref "UMLS:C4073097" ; a owl:Class ; rdfs:label "Foveal hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030613 . obo:HP_0030628 oboInOwl:hasDbXref "UMLS:C4073098" ; a owl:Class ; rdfs:label "Foveal subretinal hyporeflective spaces on macular OCT" ; rdfs:subClassOf obo:HP_0030627 . obo:HP_0030629 oboInOwl:hasDbXref "UMLS:C4073099" ; a owl:Class ; rdfs:label "Perifoveal ring of hyperautofluorescence" ; rdfs:subClassOf obo:HP_0030602 . obo:HP_0030630 oboInOwl:hasDbXref "UMLS:C4073100" ; a owl:Class ; rdfs:label "Irregular central macular autofluorescence" ; rdfs:subClassOf obo:HP_0030602 . obo:HP_0030631 obo:IAO_0000115 "Increased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging." ; oboInOwl:hasDbXref "UMLS:C4073101" ; a owl:Class ; rdfs:comment "A large portion of hyper-autofluorescent lesions results from alterations in lipofuscin metabolism. Accumulation of lipofuscin in RPE cells, accumulation of bisretinoids in photoreceptor outer segments, and photooxidation of bisretinoids in lipofuscin can all contribute to enhanced autofluorescence." ; rdfs:label "Hyperautofluorescent macular lesion" ; rdfs:subClassOf obo:HP_0025158 . obo:HP_0030632 obo:IAO_0000115 "Decreased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging." ; oboInOwl:hasDbXref "UMLS:C4073102" ; oboInOwl:hasExactSynonym "Hypo-autofluorescent macular lesion" ; a owl:Class ; rdfs:label "Hypoautofluorescent macular lesion" ; rdfs:subClassOf obo:HP_0025159 . obo:HP_0030633 oboInOwl:hasDbXref "UMLS:C4073103" ; a owl:Class ; rdfs:label "Perifoveal ring of hyperautofluorescence surrounded by normal autofluorescence" ; rdfs:subClassOf obo:HP_0030629 . obo:HP_0030634 oboInOwl:hasDbXref "UMLS:C4073104" ; a owl:Class ; rdfs:label "Perifoveal ring of hyperautofluorescence surrounded by abnormal autofluorescence" ; rdfs:subClassOf obo:HP_0030629 . obo:HP_0030635 oboInOwl:hasDbXref "UMLS:C4049066" ; a owl:Class ; rdfs:label "Retinal dystrophy with early macular involvement" ; rdfs:subClassOf obo:HP_0000556 . obo:HP_0030636 obo:IAO_0000115 "Occult macular dystrophy is a, typically hereditary, abnormality of the macula associated with progressive foveal cone dysfunction and no apparent fundoscopic, full-field electroretinogram (ERG), or fluorescein angiogram abnormalities." ; a owl:Class ; rdfs:label "Occult macular dystrophy" ; rdfs:subClassOf obo:HP_0007754 . obo:HP_0030637 obo:IAO_0000115 "Retinal phenotype characterised by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, colour vision abnormalities, nystagmus and photophobia." ; oboInOwl:hasDbXref "UMLS:C0543968" ; oboInOwl:hasExactSynonym "Cone dysfunction", "Cone dysfunction syndrome" ; a owl:Class ; rdfs:label "Congenital stationary cone dysfunction" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0030638 oboInOwl:hasDbXref "UMLS:C4073105" ; a owl:Class ; rdfs:label "Congenital stationary night blindness with normal fundus" ; rdfs:subClassOf obo:HP_0007642 . obo:HP_0030639 oboInOwl:hasDbXref "UMLS:C4073106" ; a owl:Class ; rdfs:label "Congenital stationary night blindness with abnormal fundus" ; rdfs:subClassOf obo:HP_0007642 . obo:HP_0030640 oboInOwl:hasDbXref "UMLS:C4048798" ; a owl:Class ; rdfs:label "Complete congenital stationary night blindness" ; rdfs:subClassOf obo:HP_0030638 . obo:HP_0030641 oboInOwl:hasDbXref "UMLS:C4073107" ; a owl:Class ; rdfs:label "Incomplete congenital stationary night blindness" ; rdfs:subClassOf obo:HP_0030638 . obo:HP_0030642 oboInOwl:hasDbXref "MSH:C562733", "SNOMEDCT_US:68222009", "UMLS:C0311338" ; a owl:Class ; rdfs:label "Fundus albipunctatus" ; rdfs:subClassOf obo:HP_0012045, obo:HP_0030639 . obo:HP_0030643 oboInOwl:hasDbXref "UMLS:C4073108" ; a owl:Class ; rdfs:label "Vitelliform-like retinal lesions" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0030644 oboInOwl:hasDbXref "UMLS:C4073109" ; oboInOwl:hasExactSynonym "Blind spot enlargment" ; a owl:Class ; rdfs:label "Blind-spot enlargment" ; rdfs:subClassOf obo:HP_0001123 . obo:HP_0030645 obo:IAO_0000115 "Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure." ; oboInOwl:hasDbXref "SNOMEDCT_US:26216008", "UMLS:C0205099" ; a owl:Class ; rdfs:label "Central" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030646 oboInOwl:hasDbXref "SNOMEDCT_US:14414005", "UMLS:C0205100" ; a owl:Class ; rdfs:label "Peripheral" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030647 oboInOwl:hasDbXref "UMLS:C4073110" ; a owl:Class ; rdfs:label "Paracentral" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030648 oboInOwl:hasDbXref "UMLS:C4073111" ; oboInOwl:hasExactSynonym "Mid-peripheral" ; a owl:Class ; rdfs:label "Midperipheral" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030649 oboInOwl:hasDbXref "UMLS:C4073112" ; a owl:Class ; rdfs:label "Pericentral" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030650 oboInOwl:hasDbXref "SNOMEDCT_US:87017008", "UMLS:C0205234" ; a owl:Class ; rdfs:label "Focal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030651 oboInOwl:hasDbXref "SNOMEDCT_US:524008", "UMLS:C0205292" ; a owl:Class ; rdfs:label "Multifocal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0030652 obo:IAO_0000115 "Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation." ; oboInOwl:hasDbXref "UMLS:C4073113" ; a owl:Class ; rdfs:label "Vitreous haze" ; rdfs:subClassOf obo:HP_0011531 . obo:HP_0030654 obo:IAO_0000115 "Any cystic lesion associated with the umbilical cord." ; oboInOwl:hasDbXref "UMLS:C4073114" ; a owl:Class ; rdfs:comment "Umbilical cord cysts can be single or multiple. Most usually, a solitary umbilical cyst is observed. They can be classified as (i) true cysts if they have an epithelial lining (allentoic cyst or omphalomesenteric duct cyst) or false cysts if they do not have an epithelial lining (umbilical cord pseudocyst)." ; rdfs:label "Umbilical cord cyst" ; rdfs:subClassOf obo:HP_0010881 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030655 obo:IAO_0000115 "An entwining of a segment of umbilical cord, usually without obstructing fetal circulation and commonly result from fetal slippage through a loop of the cord." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:237309005", "UMLS:C0344363" ; a owl:Class ; rdfs:comment "When the true knot remains tight, it may impede the circulation of the fetus and may result to fetal death in utero especially in labor." ; rdfs:label "Umbilical cord knot" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0030656 obo:IAO_0000115 "Focal dilation of the umbilical vein." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073115" ; a owl:Class ; rdfs:label "Umbilical vein varix" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0030657 obo:IAO_0000115 "Bleeding from the vessels of the cord with extravasation of blood into the Wharton jelly surrounding the umbilical cord vessels." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:86256001", "UMLS:C0269855" ; oboInOwl:hasExactSynonym "Umbilical cord haematoma" ; a owl:Class ; rdfs:label "Umbilical cord hematoma" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0030658 obo:IAO_0000115 "Insertion of the umbilical cord within 2 cm from the placental edge." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:51519001", "UMLS:C0266788" ; oboInOwl:hasExactSynonym "Battledore placenta", "Marginal cord insertion" ; a owl:Class ; rdfs:comment "Marginal cord insertion has an incidence of about 7 percent of births. It is associated with intrauterine growth retardation, preterm labor and development of velamentous cord insertion. The synonym battledore placenta is so named because of its resemblance to the bat used in the medieval game of battledore and shuttlecock." ; rdfs:label "Marginal umbilical cord insertion" ; rdfs:subClassOf obo:HP_0011418 . obo:HP_0030659 obo:IAO_0000115 "Insertion of the umbilical cord into the chorio-amniotic membranes of the placenta." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:77278008", "UMLS:C0266789" ; a owl:Class ; rdfs:comment "Velamentous cord insertion and an incidence of 1.1 percent of singleton births, and 8.7 to 16 percent of twin births." ; rdfs:label "Velamentous cord insertion" ; rdfs:subClassOf obo:HP_0011418 . obo:HP_0030660 obo:IAO_0000115 "Branching of the umbilical cord before its insertion into the placenta." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073116" ; a owl:Class ; rdfs:label "Furcate cord insertion" ; rdfs:subClassOf obo:HP_0011418 . obo:HP_0030661 obo:IAO_0000115 "Yellow-white inflammatory aggregates in the vitreous that are found in the midvitreous and inferior periphery." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:417393008", "UMLS:C1563272" ; a owl:Class ; rdfs:comment "Vitreous snowballs can be observed in intermediate uveitis." ; rdfs:label "Vitreous snowballs" ; rdfs:subClassOf obo:HP_0011531 . obo:HP_0030662 obo:IAO_0000115 "The presence of inflammatory cells such as lymphocytes and macrophages in the vitreous." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073117" ; a owl:Class ; rdfs:comment "Normally, there are no leukocytes in the vitreous as this is an immune-privileged site. If the blood-retinal barrier is disrupted, then leukocytes gain access to the vitreous. Vitreous inflammatory cells can be measured by flow cytometry of vitreous fluid." ; rdfs:label "Vitreous inflammatory cells" ; rdfs:subClassOf obo:HP_0011531 . obo:HP_0030663 obo:IAO_0000115 "Vestigial vitreous gel occupying the immediate retrolental space and minimal to no discernable gel in the central vitreous cavity, giving the appearance of an empty vitreous cavity." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073118" ; a owl:Class ; rdfs:label "Optically empty vitreous" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0030664 obo:IAO_0000115 "Weakness of the inferior portion of the rectus abdominal muscle, which is ascertained clinically as follows. When a patient sits up or raises the head from a recumbent position, the umbilicus is displaced toward the head. This is the result of paralysis of the inferior portion of the rectus abdominal muscle, so that the upper fibres predominate pulling upwards the umbilicus." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:61282003", "UMLS:C0231616" ; a owl:Class ; rdfs:comment "Beevor's sign is said to be characteristic of a spinal cord lesion at the T10 level, but is also described inter alia in amyotrophic lateral sclerosis and in facioscapulohumeral muscular dystrophy." ; rdfs:label "Beevor's sign" ; rdfs:subClassOf obo:HP_0009023 . obo:HP_0030665 obo:IAO_0000115 "Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D001259", "UMLS:C0750940" ; oboInOwl:hasExactSynonym "Holmes' tremor" ; a owl:Class ; rdfs:comment "Rubral tremor can be observed with midbrain injury and probably results from combined lesions of the superior cerebellar peduncle, substantia nigra, and red nucleus with interruption of the outflow pathway from the cerebellum to the motor thalamus. This tremor is present at rest but tends to be slower (3 to 5 Hz) than typical Parkinson tremor (5 to 7 Hz). It also persists unchanged or even increases with postural changes or goal-directed activity." ; rdfs:label "Rubral tremor" ; rdfs:subClassOf obo:HP_0001337 . obo:HP_0030666 obo:IAO_0000115 "In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D015861", "SNOMEDCT_US:61267008", "UMLS:C0035320" ; oboInOwl:hasExactSynonym "Retinal neovascularisation" ; a owl:Class ; rdfs:comment "When traction retinal detachment involves the macula, which is responsible for reading and driving vision, severe visual loss occurs." ; rdfs:label "Retinal neovascularization" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0030667 obo:IAO_0000115 "A type of retinal neovascularization that affects the periphery of the retina." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:247100001", "UMLS:C0474355" ; a owl:Class ; rdfs:label "Peripheral retinal neovascularization" ; rdfs:subClassOf obo:HP_0030666 . obo:HP_0030668 obo:IAO_0000115 "A cyst that is localized in the region of the orbit and exhibits an epithelial lining with a keratin-filled lumen. Hair follicles are one of the adnexal structures that are commonly found in walls of dermoid cysts." ; oboInOwl:hasDbXref "UMLS:C4073119" ; a owl:Class ; rdfs:comment "A periorbital dermoid cyst may present as a subcutaneous mass at the lateral aspect of an eyelid." ; rdfs:label "Periorbital dermoid cyst" ; rdfs:subClassOf obo:HP_0001144 . obo:HP_0030669 obo:IAO_0000115 "A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." ; oboInOwl:hasDbXref "UMLS:C4073120" ; a owl:Class ; rdfs:label "Abnormal ocular adnexa morphology" ; rdfs:subClassOf obo:HP_0032039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030670 obo:IAO_0000115 "A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the orbital region." ; oboInOwl:hasDbXref "UMLS:C4073121" ; a owl:Class ; rdfs:label "Hamartoma of the orbital region" ; rdfs:subClassOf obo:HP_0000315, obo:HP_0010566 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030671 obo:IAO_0000115 "Any anomaly of the ring of fibrous tissue that surrounds the optic nerve at its entrance at the apex of the orbit. The common tendinous ring, also known as the annulus of Zinn or annular tendon, is the origin for five of the seven extraocular muscles." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073122" ; oboInOwl:hasExactSynonym "Abnormality of the common tendinous ring" ; a owl:Class ; rdfs:label "Abnormal common tendinous ring morphology" ; rdfs:subClassOf obo:HP_0030669 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014796 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030672 obo:IAO_0000115 "The presence of small, white vitreous opacities consisting of calcium phosphate and complex, layered lipid deposits." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:95800001", "UMLS:C0521770" ; a owl:Class ; rdfs:comment "Asteroid hyalosis is a degenerative process." ; rdfs:label "Asteroid hyalosis" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0030673 obo:IAO_0000115 "A form of vitreoretinopathy characterized by thinning (erosion) of the retinal pigment epithelium that permits increased visualization of the choroidal vessels." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:C536075", "SNOMEDCT_US:232064001", "UMLS:C1840452" ; a owl:Class ; rdfs:label "Erosive vitreoretinopathy" ; rdfs:subClassOf obo:HP_0007773 . obo:HP_0030674 obo:IAO_0000115 "Onset prior to birth." ; oboInOwl:hasDbXref "UMLS:C2673646" ; oboInOwl:hasExactSynonym "Intrauterine onset", "Onset in utero", "Prenatal onset" ; a owl:Class ; rdfs:label "Antenatal onset" ; rdfs:subClassOf obo:HP_0003674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:HP_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:HsapDv_0000045 ] ) ] . obo:HP_0030675 obo:IAO_0000115 "Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd, 3rd, 4th, and 5th fingers due to structural changes in non-bony tissue." ; dc:creator "HPO_CONTRIBUTOR:NIH_jdavis" ; oboInOwl:hasDbXref "UMLS:C4073123" ; a owl:Class ; rdfs:label "Contracture of proximal interphalangeal joints of 2nd-5th fingers" ; rdfs:subClassOf obo:HP_0001215 . obo:HP_0030676 obo:IAO_0000115 "Sharp pointed superior portion of the ear, with variable overfolding of the helix." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4048833" ; oboInOwl:hasExactSynonym "Devil ear" ; a owl:Class ; rdfs:comment "The satyr ear appears to have an abnormally small upper-lateral portion. More extensive underdevelopment continuing down to and including the lobe produces a more extreme anomaly that, unfortunately, has been called Devil ear." ; rdfs:label "Satyr ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030677 obo:IAO_0000115 "A congenital auricular deformity, which is mainly characterized by a bulging appearance of the anterosuperior portion of the auricle, a convexly protruded cavum conchae, and a slit-like narrowing of the orifice of the external auditory meatus." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073124" ; a owl:Class ; rdfs:label "Mozart ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0030679 obo:IAO_0000115 "A hypopigmented spot in the shape of a leaf from the mountain ash tree." ; oboInOwl:hasDbXref "UMLS:C4073125" ; a owl:Class ; rdfs:comment "Wood's light is a blue light with an emission peak of 360 nm. The blue end of visible light is absorbed by epidermal pigmentation. If there is no epidermal pigmentation in a site, the area will appear nonpigmented as compared with the surrounding skin. Minimally visible hypopigmented spots are more easily visualized with the Wood's lamp. Ash-leaf spots are only one variety of hypopigmented macules present on the skin of patients who have tuberous sclerosis." ; rdfs:label "Ash-leaf spot" ; rdfs:subClassOf obo:HP_0009719 . obo:HP_0030680 obo:IAO_0000115 "Any structural anomaly of the heart and great vessels." ; oboInOwl:hasAlternativeId "HP:0001632", "HP:0002564", "HP:0002565" ; oboInOwl:hasDbXref "UMLS:C4049796" ; oboInOwl:hasExactSynonym "Cardiovascular malformations" ; oboInOwl:id "HP:0030680" ; a owl:Class ; rdfs:label "Abnormality of cardiovascular system morphology" ; rdfs:subClassOf obo:HP_0001626 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030681 obo:IAO_0000115 "Any structural anomaly of the muscular columns which project from the inner surface of the right and left ventricles of the heart (cardiac trabeculae, trabeculae carneae)." ; oboInOwl:hasDbXref "UMLS:C4073289" ; a owl:Class ; rdfs:label "Abnormal morphology of myocardial trabeculae" ; rdfs:subClassOf obo:HP_0001637 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004124 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030682 obo:IAO_0000115 "Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer." ; oboInOwl:hasDbXref "UMLS:C1960469" ; a owl:Class ; rdfs:label "Left ventricular noncompaction" ; rdfs:subClassOf obo:HP_0031192 . obo:HP_0030683 obo:IAO_0000115 "Inflammation of the vagina that can result from a spectrum of conditions that cause vaginal and sometimes vulvar symptoms, such as itching, burning, irritation, odor, and vaginal discharge." ; oboInOwl:hasDbXref "MSH:D014627", "SNOMEDCT_US:30800001", "UMLS:C0042267" ; oboInOwl:hasRelatedSynonym "Vulvovaginitis" ; a owl:Class ; rdfs:comment "The most common infectious causes of vaginitis are bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. Physicians traditionally diagnose vaginitis using the combination of symptoms, physical examination, pH of vaginal fluid, microscopy, and the whiff test." ; rdfs:label "Vaginitis" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030684 obo:IAO_0000115 "A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism." ; oboInOwl:hasDbXref "UMLS:C4073126" ; a owl:Class ; rdfs:comment "Lower circulating adiponectin levels is associated with obesity and negatively correlated with insulin resistance. Adiponectin may exert antidiabetic, anti-atherogenic and anti-inflammatory activities in metabolic diseases." ; rdfs:label "Abnormal adiponectin level" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_Q15848 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030685 obo:IAO_0000115 "A reduced circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue." ; oboInOwl:hasDbXref "UMLS:C4073127" ; a owl:Class ; rdfs:label "Decreased adiponectin level" ; rdfs:subClassOf obo:HP_0030684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_Q15848 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030686 obo:IAO_0000115 "An elevated circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue." ; oboInOwl:hasDbXref "UMLS:C4073128" ; a owl:Class ; rdfs:label "Increased adiponectin level" ; rdfs:subClassOf obo:HP_0030684 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_Q15848 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030687 obo:IAO_0000115 "A deviation from the normal concentration of glucagon in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4073129" ; a owl:Class ; rdfs:comment "Glucagon is a 29-amino acid polypeptide that is manufactured by the alpha cells of the pancreatic islets. It plays a key role in glucose counterregulation in response to hypoglycemia. Hypoglycemia is normally a powerful stimulator of glucagon secretion." ; rdfs:label "Abnormal glucagon level" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030688 obo:IAO_0000115 "An elevated concentration of glucagon in the blood circulation." ; oboInOwl:hasDbXref "SNOMEDCT_US:131106002", "UMLS:C1295677" ; a owl:Class ; rdfs:label "Increased glucagon level" ; rdfs:subClassOf obo:HP_0030687 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030689 obo:IAO_0000115 "A reduced concentration of glucagon in the blood circulation." ; oboInOwl:hasDbXref "SNOMEDCT_US:131107006", "UMLS:C1295678" ; a owl:Class ; rdfs:label "Decreased glucagon level" ; rdfs:subClassOf obo:HP_0030687 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030690 obo:IAO_0000115 "A fissure in the gingiva (gums), i.e., the mucosal tissue that lies over the mandible and maxilla." ; oboInOwl:hasDbXref "SNOMEDCT_US:109622003", "UMLS:C0426489" ; a owl:Class ; rdfs:label "Gingival cleft" ; rdfs:subClassOf obo:HP_0000168 . obo:HP_0030691 obo:IAO_0000115 "A condition in which both eyes beat outward simultaneously." ; oboInOwl:hasDbXref "UMLS:C4073130" ; a owl:Class ; rdfs:comment "This is a rare condition that may be related to posterior foass abnormalities and can occur with spinocerebellar degeneration." ; rdfs:label "Divergence nystagmus" ; rdfs:subClassOf obo:HP_0000639 . obo:HP_0030692 obo:IAO_0000115 "A benign or malignant neoplasm that arises from or metastasizes to the brain." ; oboInOwl:hasDbXref "MSH:D001932", "NCIT:C2907", "SNOMEDCT_US:126952004", "SNOMEDCT_US:254935002", "UMLS:C0006118" ; oboInOwl:hasExactSynonym "Brain tumor", "Brain tumour" ; a owl:Class ; rdfs:label "Brain neoplasm" ; rdfs:subClassOf obo:HP_0012443, obo:HP_0100006 . obo:HP_0030693 obo:IAO_0000115 "A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli." ; oboInOwl:hasDbXref "MSH:D010871", "MSH:D015173", "NCIT:C3328", "SNOMEDCT_US:127026004", "SNOMEDCT_US:359619007", "SNOMEDCT_US:47598005", "UMLS:C0031941", "UMLS:C0038874" ; oboInOwl:hasExactSynonym "Pineal parenchymal tumor", "Pineal parenchymal tumour" ; a owl:Class ; rdfs:comment "This represents a group of related tumors ranging from the relatively benign to the highly malignant." ; rdfs:label "Supratentorial neoplasm" ; rdfs:subClassOf obo:HP_0030692 . obo:HP_0030694 oboInOwl:hasDbXref "MSH:D010871", "SNOMEDCT_US:127026004", "SNOMEDCT_US:359619007", "SNOMEDCT_US:47598005", "UMLS:C0031941" ; a owl:Class ; rdfs:label "Pineal parenchymal cell neoplasm" ; rdfs:subClassOf obo:HP_0010799 . obo:HP_0030706 obo:IAO_0000115 "A ranula is a mucocele that occurs in the floor of the mouth and usually involve the major salivary glands. Specifically, the ranula originates in the body of the sublingual gland, in the ducts of the sublingual gland, in the Wharton's duct of the submandibular gland or infrequently from the minor salivary glands at this location." ; oboInOwl:hasDbXref "MSH:D011900", "SNOMEDCT_US:14919007", "UMLS:C2242813" ; oboInOwl:hasExactSynonym "Sublingual cyst", "Sublingual ptyalocele" ; a owl:Class ; rdfs:label "Ranula" ; rdfs:subClassOf obo:HP_0010286 . obo:HP_0030707 obo:IAO_0000115 "Lack of development of one lung." ; oboInOwl:hasDbXref "MSH:C562992", "UMLS:C4082952" ; oboInOwl:hasExactSynonym "Unilateral pulmonary agenesis" ; a owl:Class ; rdfs:label "Unilateral lung agenesis" ; rdfs:subClassOf obo:HP_0006703 . obo:HP_0030708 obo:IAO_0000115 "The severe form of a neural tube defect where the open neural tube appears as a flattened, plate-like mass of nervous tissue with no overlying membrane." ; oboInOwl:hasDbXref "SNOMEDCT_US:360530005", "UMLS:C0266507" ; a owl:Class ; rdfs:comment "Myeloschisis is a cleft spinal cord arising from a failure of neural tube closure. The placode is defined as a plate of embryonic epithelial cells constituting a primordial cell group from which the spinal cord arises and is often seen in a myelomeningocele. In a myelomeningocele, an exposed placode is often a myeloschisis. In other words, a myeloschisis is a collapsed myelomeningocele. When the placode in the myelomeningocele sac is a cleft spinal cord, this anomaly is classified as myeloschisis rather than myelomeningocele." ; rdfs:label "Myeloschisis" ; rdfs:subClassOf obo:HP_0010301, obo:HP_0034237 . obo:HP_0030709 obo:IAO_0000115 "Myelocystocele is characterized by a large, ependyma-lined, cystic dilation of the caudal end of the central canal of the spinal cord; it projects dorsally through a lamina defect, with overlying varying amounts of lipomatous subcutaneous tissue. Myelocystoceles are associated with a tethered cord and meningocele, which communicates with the spinal subarachnoid space, but not with the central canal cyst." ; oboInOwl:hasDbXref "MSH:D008591", "SNOMEDCT_US:203994003", "SNOMEDCT_US:414667000", "UMLS:C0025312" ; a owl:Class ; rdfs:comment "Localized dilatation of the central canal of the spinal cord which produces a fluid-filled sac or diverticulum which then protrudes through the cord and the defective dorsal dura between the posterior parts of the vertebra." ; rdfs:label "Myelocystocele" ; rdfs:subClassOf obo:HP_0002196 . obo:HP_0030710 obo:IAO_0000115 "A form of closed neural tube defect in which the spinal tissue lies within the spinal cord having a junction between the spinal cord and the lipoma. Intact skin covers the defect. Neurologic findings first appear during the second year of life." ; oboInOwl:hasDbXref "SNOMEDCT_US:253120005", "UMLS:C0431344" ; a owl:Class ; rdfs:label "Lipomeningocele" ; rdfs:subClassOf obo:HP_0002435 . obo:HP_0030711 obo:IAO_0000115 "Distention of the vagina caused by accumulation of fluid due to congenital vaginal obstruction." ; oboInOwl:hasDbXref "MSH:D052202", "UMLS:C1399870" ; a owl:Class ; rdfs:comment "This term is distinct from Hydrometrocolpos (HP:0030010), which indicates additional uterine dilation." ; rdfs:label "Hydrocolpos" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0030712 obo:IAO_0000115 "Adhesions or scar tissue that form inside the cavity of the uterus." ; oboInOwl:hasDbXref "MSH:D006175", "SNOMEDCT_US:48236007", "UMLS:C0156372" ; oboInOwl:hasRelatedSynonym "Asherman syndrome" ; a owl:Class ; rdfs:comment "Asherman syndrome is a condition characterized by formation of intrauterine adhesions and results from injury to the endometrium. Asherman syndrome is often associated with infertility." ; rdfs:label "Uterine synechiae" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0030713 obo:IAO_0000115 "Vein of Galen aneurysmal malformation is a choroidal type of arteriovenous malformation that develops between 6 and 11 weeks of gestation. It results from 1 or more arteriovenous fistulas shunting blood toward the prosencephalic vein of Markowski, the embryonic precursor of the vein of Galen. This abnormal shunt leads to progressive dilation of the vein and prevents its involution and subsequent development into the vein of Galen." ; oboInOwl:hasDbXref "MSH:C536535", "SNOMEDCT_US:253194008", "UMLS:C0431420" ; oboInOwl:hasExactSynonym "Median prosencephalic arteriovenous fistula", "Vein of Galen aneurysm", "Vein of Galen malformation" ; a owl:Class ; rdfs:comment "The most common vascular CNS anomaly in the fetal brain is the vein of Galen malformation. At prenatal US, an anechoic cystic mass is seen in the midline, superior and posterior to the third ventricle and thalamus. Color and spectral Doppler imaging demonstrate the presence of low-resistance flow and a turbulent waveform. Blood flow may be seen draining posteriorly into the venous sinuses. See Figure 13 of PMID:32706613." ; rdfs:label "Vein of Galen aneurysmal malformation" ; rdfs:subClassOf obo:HP_0012480 . obo:HP_0030714 obo:IAO_0000115 "A large maternal clot that separates the chorionic plate from the villous chorion." ; oboInOwl:hasDbXref "UMLS:C1390676" ; oboInOwl:hasExactSynonym "Breus' mole" ; a owl:Class ; rdfs:label "Subchorionic thrombohematoma" ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0030715 obo:IAO_0000115 "A developmental anomaly characterised by focal obliteration of the proximal segment of a bronchus. The bronchial pattern is entirely normal distal to the site of stenosis." ; oboInOwl:hasDbXref "SNOMEDCT_US:50513008", "UMLS:C0265776" ; oboInOwl:hasExactSynonym "Congenital bronchial atresia" ; a owl:Class ; rdfs:label "Bronchial atresia" ; rdfs:subClassOf obo:HP_0025426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002185 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030716 obo:IAO_0000115 "Partial or complete absence of the flat bones of the cranial vault. The condition is frequently, though not always, associated with anencephaly." ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:203923004", "UMLS:C0702169" ; a owl:Class ; rdfs:label "Acrania" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0030717 obo:IAO_0000115 "Peritonitis caused by intrauterine intestinal rupture and spillage of fetal meconium into the fetal peritoneal cavity. Intra-peritoneal meconium usually calcifies, sometimes within 24 hours. Ultrasound findings may include intraabdominal calcifications." ; oboInOwl:hasDbXref "SNOMEDCT_US:57341009", "UMLS:C0270250" ; a owl:Class ; rdfs:label "Meconium peritonitis" ; rdfs:subClassOf obo:HP_0002586 . obo:HP_0030718 obo:IAO_0000115 "Increase in size of the right atrium." ; oboInOwl:hasDbXref "Fyler:1771", "Fyler:2859", "SNOMEDCT_US:67751000119106", "UMLS:C0748427" ; oboInOwl:hasExactSynonym "Dilated right atrium", "Enlarged heart right atrium", "Right atrial dilatation" ; a owl:Class ; rdfs:comment "This feature can be appreciated on chext radiography, MRI, or CT." ; rdfs:label "Right atrial enlargement" ; rdfs:subClassOf obo:HP_0025580 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030719 obo:IAO_0000115 "A form of agenesis of the tricuspid valve in which (although the normal orifice between the right atrium and right ventricle exists) there is no tricuspid valvular tissue." ; oboInOwl:hasDbXref "SNOMEDCT_US:253381001", "UMLS:C0344745" ; oboInOwl:hasExactSynonym "Rudimentary tricuspid valve leaflets", "Unguarded tricuspid valve orifice" ; a owl:Class ; rdfs:label "Unguarded tricuspid valve" ; rdfs:subClassOf obo:HP_0011662 . obo:HP_0030720 obo:IAO_0000115 "Cyst on the surface of the placenta consisting of amnion and chorion." ; oboInOwl:hasDbXref "UMLS:C4280801" ; a owl:Class ; rdfs:label "Subchorionic septal cyst" ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0030721 obo:IAO_0000115 "Phocomelia involving all four extremities." ; oboInOwl:hasDbXref "UMLS:C1849370" ; a owl:Class ; rdfs:label "Tetraphocomelia" ; rdfs:subClassOf obo:HP_0009829 . obo:HP_0030722 obo:IAO_0000115 "Ectopic liver is a rare developmental anomaly in which liver tissue is situated outside the liver. Thus, ectopic liver refers to autonomous islands of normal liver parenchyma located outside the liver. The term ectopic liver is also used, to include liver appendices attached to the native liver by a thin stalk although being fully separated from the latter." ; oboInOwl:hasDbXref "SNOMEDCT_US:253813000", "UMLS:C0431603" ; a owl:Class ; rdfs:comment "Ectopic liver tissue can occur in several different organs, but the gallbladder is the commonest site of origin." ; rdfs:label "Ectopic liver" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030723 obo:IAO_0000115 "Dilation and elongation of the penile urethra associated with absence or hypoplasia of the corpora spongiosa and cavernosa." ; oboInOwl:hasDbXref "UMLS:C4280800" ; a owl:Class ; rdfs:label "Congenital megalourethra" ; rdfs:subClassOf obo:HP_0000795 . obo:HP_0030724 obo:IAO_0000115 "A fluid-filled sac (cyst) located within the central nervous system." ; oboInOwl:hasDbXref "MSH:D020863", "SNOMEDCT_US:277333006", "UMLS:C0349606" ; oboInOwl:hasExactSynonym "CNS cyst", "Cyst of the central nervous system" ; a owl:Class ; rdfs:comment "Cysts of CNS are usually maldevelopmental in nature, but in some cases are acquired. The recognition of these cysts radiologically and confirmation by pathology is essential for prognostic purposes." ; rdfs:label "Central nervous system cyst" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030725 obo:IAO_0000115 "The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium." ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:253127008", "SNOMEDCT_US:41353005", "UMLS:C0027806" ; a owl:Class ; rdfs:comment "Individuals diagnosed with neurenteric cysts most frequently present in the second and third decades of life with a male-to-female ratio of approximately 2:1. Moreover, in the pediatric population, 61.2 percent of patients found to have neurenteric cysts are male with a mean age of 6.4 years at presentation. The majority of adult patients with neurenteric cysts present with progressive focal pain at the level of spinal axis pathology, fluctuating myelopathic signs, or radicular symptoms." ; rdfs:label "Neurenteric cyst" ; rdfs:subClassOf obo:HP_0030724 . obo:HP_0030726 obo:IAO_0000115 "A neurenteric cyst located in the spine." ; oboInOwl:hasDbXref "UMLS:C4280799" ; a owl:Class ; rdfs:label "Spinal neurenteric cyst" ; rdfs:subClassOf obo:HP_0030725 . obo:HP_0030727 obo:IAO_0000115 "A neurenteric cyst located within the skull." ; oboInOwl:hasDbXref "UMLS:C4280680" ; a owl:Class ; rdfs:label "Intracranial neurenteric cyst" ; rdfs:subClassOf obo:HP_0030725 . obo:HP_0030728 obo:IAO_0000115 "Partial absence of a free limb (excluding girdle). It can refer to the proximal, middle or distal segment of the upper or lower limb. The deficiency may be transverse or longitudinal. Thus, meromelia is a lack of a part, but not all, of one or more limbs with the presence of a hand or foot." ; oboInOwl:hasDbXref "SNOMEDCT_US:60220000", "UMLS:C0265549" ; a owl:Class ; rdfs:label "Meromelia" ; rdfs:subClassOf obo:HP_0009826 . obo:HP_0030729 obo:IAO_0000115 "A herniation of meninges through a congenital bone defect in the skull at the junction of the frontal and ethmoidal bones." ; oboInOwl:hasDbXref "UMLS:C4280798" ; oboInOwl:hasExactSynonym "Frontoethmoid meningocele" ; a owl:Class ; rdfs:label "Frontoethmoidal meningocele" ; rdfs:subClassOf obo:HP_0002435 . obo:HP_0030730 obo:IAO_0000115 "A herniation of meninges through a congenital bone defect in the skull in the parietal region." ; oboInOwl:hasDbXref "UMLS:C4280797" ; a owl:Class ; rdfs:label "Parietal meningocele" ; rdfs:subClassOf obo:HP_0002435 . obo:HP_0030731 obo:IAO_0000115 "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus)." ; oboInOwl:hasDbXref "MSH:D002277", "NCIT:C2916", "SNOMEDCT_US:68453008", "UMLS:C0007097" ; a owl:Class ; rdfs:label "Carcinoma" ; rdfs:subClassOf obo:HP_0031492 . obo:HP_0030732 obo:IAO_0000115 "A congenital malformation of the tricuspid valve characterized by leaflet deformation." ; oboInOwl:hasDbXref "UMLS:C4255215" ; oboInOwl:hasExactSynonym "Tricuspid valve dysplasia" ; a owl:Class ; rdfs:comment "Malformations of the tricuspid valve include a wide range of morphologic features that can be divided into two main groups: those in which the primary lesion is downward displacement of the basal attachment of the mural and septal (or both) leaflets, known as Ebstein's malformation (1), and those without downward displacement but with deformation of the leaflets and the tension apparatus, an arrangement described as dysplasia. In severe cases of dysplasia, the tricuspid valve orifice may become unguarded. Although there is a broad morphologic spectrum, these malformations lead to the same hemodynamic burden, namely, tricuspid regurgitation (TR) and its pathophysiological sequelae." ; rdfs:label "Dysplastic tricuspid valve" ; rdfs:subClassOf obo:HP_0001702 . obo:HP_0030733 obo:IAO_0000115 "An abdominal wall defected related to a developmental anomaly of the allantois, which is an embryonic structure that develops as a diverticulum off the yolk sac at about 16 days post fertilization. During further development, the allantois becomes incorporated into the body of the embryo, connecting the ventral aspect of the urogenital sinus (which will develop into the upper pole of the urinary bladder) to the external portion of the umbilicus. Upon further development, the lumen of the allantois becomes obliterated and forms a thick fibrous cord called the urachus, which connects the apex of the bladder to the umbilicus. In adults, the urachus is known as the median umbilical ligament. Failure of the allantoic cavity to obliterate can result of one of four conditions: 1) congenital patent urachus (a completely open connection between bladder and umbilicus); 2) vesicourachal diverticulum (a diverticulum off the bladder but not communicating with the umbilicus); umbilical cyst and sinus (not communicating with the bladder); and 4) alternating urachal sinus. An abdominal wall defect can be associated with a urachal cyst." ; oboInOwl:hasDbXref "UMLS:C4280796" ; a owl:Class ; rdfs:label "Vesicoallantoic abdominal wall defect" ; rdfs:subClassOf obo:HP_0010478 . obo:HP_0030735 obo:IAO_0000115 "Blockage at the level of the bladder and the ureter caused by stenosis of the ureteral valves or failure of a narrow juxtavesical ureteral segment to dilate due to segmented fibrosis or localized absence of muscle." ; oboInOwl:hasDbXref "UMLS:C2609249" ; a owl:Class ; rdfs:label "Ureterovesical junction obstruction" ; rdfs:subClassOf obo:HP_0006000 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009973 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030736 obo:IAO_0000115 "A teratoma arising in the sacro-coccygeal region." ; oboInOwl:hasDbXref "SNOMEDCT_US:281561000", "UMLS:C0559459" ; a owl:Class ; rdfs:comment "Sacrococcygeal teratomas arise from totipotent cells from the node of Hensen at the anterior aspect of the coccyx by about the 2nd to 3rd weeks of gestation, and are composed of the all three germ cells (i.e. ectoderm, mesoderm and endoderm). Sacrococcygeal teratomas are classified according to their relative extent outside and inside the body. Altman type I: entirely outside, sometimes attached to the body only by a narrow stalk; Altman type II: mostly outside; Altman type III: mostly inside; Altman type IV: entirely inside." ; rdfs:label "Sacrococcygeal teratoma" ; rdfs:subClassOf obo:HP_0005107, obo:HP_0009792 . obo:HP_0030737 obo:IAO_0000115 "A type of sacrococcygeal teratoma that is predominantly external and projects from the sacrococcygeal region and presents with distortion of the buttocks." ; oboInOwl:hasDbXref "UMLS:C4280795" ; a owl:Class ; rdfs:label "Altman type I sacrococcygeal teratoma" ; rdfs:subClassOf obo:HP_0030736 . obo:HP_0030738 obo:IAO_0000115 "A type of sacrococcygeal teratoma that is predominantly external but has a large intrapelvic component." ; oboInOwl:hasDbXref "UMLS:C4280794" ; a owl:Class ; rdfs:label "Altman type II sacrococcygeal teratoma" ; rdfs:subClassOf obo:HP_0030736 . obo:HP_0030739 obo:IAO_0000115 "A type of sacrococcygeal teratoma that is predominantly intrapelvic with a small external, buttock mass." ; oboInOwl:hasDbXref "UMLS:C4280793" ; a owl:Class ; rdfs:label "Altman type III sacrococcygeal teratoma" ; rdfs:subClassOf obo:HP_0030736 . obo:HP_0030740 obo:IAO_0000115 "An accessory (not normally present) muscle bundle in the right ventricle which obstructs the right ventricular outflow tract." ; oboInOwl:hasDbXref "UMLS:C4280792" ; oboInOwl:hasExactSynonym "Right ventricular anomalous muscle bundle" ; a owl:Class ; rdfs:comment "The anomalous muscle bundle is triangular in shape, with its apex attached to the anterior aspect of the ventricular septum immediately above and in front of the ventricular septal defect. It crosses the right ventricular chamber to insert at the apical portion of the anterior wall of the right ventricle (PMID:708529)." ; rdfs:label "Anomalous muscle bundle of the right ventricle" ; rdfs:subClassOf obo:HP_0001707 . obo:HP_0030741 obo:IAO_0000115 "A teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs)." ; oboInOwl:hasDbXref "NCIT:C6438", "UMLS:C1334682" ; oboInOwl:hasExactSynonym "Teratoma of the mediastinum" ; a owl:Class ; rdfs:label "Mediastinal teratoma" ; rdfs:subClassOf obo:HP_0009792 . obo:HP_0030742 obo:IAO_0000115 "This anomaly, also known as Mittendorf dot, is a benign, nonprogressive recognizable lesion that does not cause visual impairment. However, it can resemble a pathological congenital or acquired cataract lesion which may enlarge and cause visual impairment. The dot appears as a black speck that ranges in size from the dot made by a sharp pencil point to the size of a poppy seed. It is usually well defined, although occasionally there may be irregular, fine lines radiating outward from the dot." ; oboInOwl:hasDbXref "SNOMEDCT_US:370483001", "UMLS:C1299892" ; oboInOwl:hasExactSynonym "Mittendorf dot" ; a owl:Class ; rdfs:label "Glial remnants posterior to lens" ; rdfs:subClassOf obo:HP_0007968 . obo:HP_0030743 obo:IAO_0000115 "Persistance of a posterior remnant of the hyaloid artery located at the optic disc." ; oboInOwl:hasDbXref "UMLS:C4280791" ; oboInOwl:hasExactSynonym "Bergmeister papilla" ; a owl:Class ; rdfs:label "Glial remnants anterior to the optic disc" ; rdfs:subClassOf obo:HP_0007968 . obo:HP_0030744 obo:IAO_0000115 "A type of persistance of the hyaloid vascular system associated with a retrolental mass that may lead to fetal cataract." ; oboInOwl:hasDbXref "UMLS:C4280790" ; a owl:Class ; rdfs:label "Hyaloid vascular remnant and retrolental mass" ; rdfs:subClassOf obo:HP_0007968 . obo:HP_0030745 obo:IAO_0000115 "Ductus arteriosus aneurysm (DAA) is a saccular dilatation of the ductus arteriosus. DAA can be either congenital or acquired (e.g. as a complication of surgical closure of a patent ductus arteriosus). Although the majority of patients with congenital DAA are asymptomatic and have a benign course, severe complications, such as rupture or thromboembolism, can occur. DAA is likely to emerge in the third trimester from the aortic junction of the DA, extending towards its pulmonary end." ; oboInOwl:hasDbXref "SNOMEDCT_US:233990006", "UMLS:C0398357" ; oboInOwl:hasExactSynonym "Aneurysm of the ductus arteriosus" ; oboInOwl:hasNarrowSynonym "Congenital ductus arteriosus aneurysm", "Ductus arteriosus aneurysm" ; a owl:Class ; rdfs:comment "Ductus arteriosus aneurysm has been observed in patients with connective tissue disorders like Marfan and Ehlers-Danlos syndrome and in patients with chromosomal syndromes (e.g. Williams, Larsen, aneuploidies). Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of the ductus arteriosus" ; rdfs:subClassOf obo:HP_0002617, obo:HP_0011603 . obo:HP_0030746 obo:IAO_0000115 "Bleeding into the ventricles of the brain." ; oboInOwl:hasDbXref "SNOMEDCT_US:23276006", "UMLS:C0240059" ; oboInOwl:hasExactSynonym "Intraventricular haemorrhage" ; a owl:Class ; rdfs:label "Intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0002170 . obo:HP_0030747 obo:IAO_0000115 "Intraventricular hemorrhage that occurs in a premature infant." ; oboInOwl:hasDbXref "UMLS:C4280789" ; oboInOwl:hasExactSynonym "Preterm intraventricular haemorrhage" ; a owl:Class ; rdfs:comment "This is a common complication seen in preterm infacnts since the cerebral blood vessels are not yet fully developed. Infants born more than 10 weeks early are at highest risk for this type of bleeding." ; rdfs:label "Preterm intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0030746 . obo:HP_0030748 obo:IAO_0000115 "Intraventricular hemorrhage that occurs in a preterm infant and that is restricted to subependymal region/germline matrix which is seen in the caudothalamic groove." ; oboInOwl:hasDbXref "SNOMEDCT_US:276650005", "UMLS:C0475737" ; oboInOwl:hasExactSynonym "Germinal matrix haemorrhage", "Germinal matrix hemorrhage", "Grade I preterm intraventricular haemorrhage" ; a owl:Class ; rdfs:label "Grade I preterm intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0030747 . obo:HP_0030749 obo:IAO_0000115 "Intraventricular hemorrhage that occurs in a preterm infant and that has extension into normal-sized ventricles and typically fills less than 50% of the volume of the ventricle." ; oboInOwl:hasDbXref "UMLS:C4280788" ; oboInOwl:hasExactSynonym "Grade II preterm intraventricular haemorrhage" ; a owl:Class ; rdfs:label "Grade II preterm intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0030747 . obo:HP_0030750 obo:IAO_0000115 "Intraventricular hemorrhage that occurs in a preterm infant and that has extension into dilated ventricles." ; oboInOwl:hasDbXref "UMLS:C4280787" ; oboInOwl:hasExactSynonym "Grade III preterm intraventricular haemorrhage" ; a owl:Class ; rdfs:label "Grade III preterm intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0030747 . obo:HP_0030751 obo:IAO_0000115 "Intraventricular hemorrhage that occurs in a preterm infant and that shows parenchymal extension." ; oboInOwl:hasDbXref "UMLS:C4280786" ; oboInOwl:hasExactSynonym "Grade IV preterm intraventricular haemorrhage" ; a owl:Class ; rdfs:label "Grade IV preterm intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0030747 . obo:HP_0030752 obo:IAO_0000115 "A nasolacrimal duct obstruction presenting as a grey-blue cystic swelling just below the medial canthus. Believed to be a result of concomitant upper obstruction of the Rosenmuller valve and lower obstruction of the Hasner valve." ; oboInOwl:hasDbXref "SNOMEDCT_US:42758002", "UMLS:C0155241" ; oboInOwl:hasExactSynonym "Timo cyst" ; a owl:Class ; rdfs:label "Dacryocystocele" ; rdfs:subClassOf obo:HP_0000579 . obo:HP_0030753 obo:IAO_0000115 "Loss of one twin occurring after midgestation (17 weeks gestation)." ; oboInOwl:hasDbXref "UMLS:C4280785" ; oboInOwl:hasExactSynonym "Intrauterine foetal demise of one twin after midgestation" ; oboInOwl:hasRelatedSynonym "Single-twin demise" ; a owl:Class ; rdfs:comment "Loss of one twin in the first trimester does not appear to impair the development of the surviving twin. However, fetal death occurring after midgestation (17 weeks' gestation) may increase the risk of IUGR, preterm labor, preeclampsia and perinatal mortality." ; rdfs:label "Intrauterine fetal demise of one twin after midgestation" ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0030754 obo:IAO_0000115 "A swelling formed at the base of umbilicus associated with a patent urachus which results from an allantoic remnant. The urachus is a fibrous remnant of the allantois which communicates from the apex of the urinary bladder to the umbilicus. Failed obliteration of the urachus can lead to various abnormalities: urachal cyst, urachal diverticulum, sinus or patent urachus - the most common type. Allantoic cysts in infants with patent urachus can be formed due to the drainage of urine into the umbilical cord, or in uncommon situations, after leakage of hypo-osmotic urine into the Wharton's jelly." ; oboInOwl:hasDbXref "MSH:D014496", "SNOMEDCT_US:17234001", "UMLS:C0041915" ; a owl:Class ; rdfs:label "Allantoic cyst" ; rdfs:subClassOf obo:HP_0010478 . obo:HP_0030755 obo:IAO_0000115 "A teratoma located in the craniofacial region." ; oboInOwl:hasDbXref "NCIT:C3403", "UMLS:C4280784" ; a owl:Class ; rdfs:label "Craniofacial teratoma" ; rdfs:subClassOf obo:HP_0009792 . obo:HP_0030756 obo:IAO_0000115 "Reddish, brown opalescent discoloration of teeth in normal light." ; oboInOwl:hasDbXref "UMLS:C4280783" ; oboInOwl:hasExactSynonym "Red teeth" ; a owl:Class ; rdfs:comment "This feature is characteristic of Congenital erythropoietic porphyria (CEP), an autosomal recessive disorder caused by mutation in the gene that codifies uroporphyrinogen-III synthase, leading to porphyrin accumulation in many tissues." ; rdfs:label "Erythrodontia" ; rdfs:subClassOf obo:HP_0011073 . obo:HP_0030757 obo:IAO_0000115 "A pocket of pus located within a region of a tooth." ; oboInOwl:hasDbXref "SNOMEDCT_US:299709002", "UMLS:C0518988" ; oboInOwl:hasExactSynonym "Dental abscess", "Dentoalveolar abscess" ; a owl:Class ; rdfs:label "Tooth abscess" ; rdfs:subClassOf obo:HP_0011061, obo:HP_0025615 . obo:HP_0030758 obo:IAO_0000115 "A tooth abscess that occurs at the tip of the root (apex) of a tooth." ; oboInOwl:hasDbXref "UMLS:C4280782" ; a owl:Class ; rdfs:label "Periapical tooth abscess" ; rdfs:subClassOf obo:HP_0030757 . obo:HP_0030759 obo:IAO_0000115 "An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy." ; oboInOwl:hasDbXref "UMLS:C4280781" ; oboInOwl:hasExactSynonym "Fat cell hypertrophy" ; a owl:Class ; rdfs:label "Adipocyte hypertrophy" ; rdfs:subClassOf obo:HP_0009124 . obo:HP_0030760 obo:IAO_0000115 "Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease." ; oboInOwl:hasDbXref "SNOMEDCT_US:197660000", "UMLS:C0151650" ; oboInOwl:hasExactSynonym "Kidney fibrosis" ; a owl:Class ; rdfs:label "Renal fibrosis" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0030761 obo:IAO_0100001 "HP:0000096" ; a owl:Class ; rdfs:label "obsolete Renal glomerular fibrosis" ; owl:deprecated true . obo:HP_0030762 obo:IAO_0000115 "Partial or complete dissolution of the mesangial matrix, identified by reduced staining on a periodic acid-Schiff (PAS) or silver stain." ; oboInOwl:hasDbXref "UMLS:C4054531" ; a owl:Class ; rdfs:comment "Dissolution or attenuation of mesangial matrix and degeneration of mesangial cells. In essence, mesangiolysis is an injurious process which affects the glomerular mesangium without causing obvious damage to the capillary basement membranes. The matrix swells, loosens, and eventually dissolves; the mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis." ; rdfs:label "Mesangiolysis" ; rdfs:subClassOf obo:HP_0033232 . obo:HP_0030763 obo:IAO_0000115 "A sheet like projection that can result from uterine synechiae that has been encompassed by the expanding chorion and amnion." ; oboInOwl:hasDbXref "UMLS:C4280779" ; oboInOwl:hasExactSynonym "Amniotic shelf" ; a owl:Class ; rdfs:label "Amniotic Sheet" ; rdfs:subClassOf obo:HP_0011409 . obo:HP_0030764 obo:IAO_0000115 "Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved." ; oboInOwl:hasDbXref "MSH:D009794", "SNOMEDCT_US:410042009", "UMLS:C0028817" ; a owl:Class ; rdfs:label "Ochronosis" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0030765 obo:IAO_0000115 "Episodes of intense fear, screaming and flailing although affected individuals are still asleep." ; oboInOwl:hasDbXref "MSH:D020184", "SNOMEDCT_US:89675003", "UMLS:C0037320" ; oboInOwl:hasExactSynonym "Night terror", "Pavor nocturnus", "Sleep terrors" ; a owl:Class ; rdfs:comment "Sleep terrors may occur in individuals who are sleepwalking." ; rdfs:label "Sleep terror" ; rdfs:subClassOf obo:HP_0025235 . obo:HP_0030766 obo:IAO_0000115 "Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia)." ; oboInOwl:hasDbXref "MSH:D004433", "SNOMEDCT_US:16001004", "SNOMEDCT_US:162356005", "UMLS:C0013456" ; oboInOwl:hasExactSynonym "Ear pain", "Otalgia", "Pain in the ear" ; a owl:Class ; rdfs:label "Ear pain" ; rdfs:subClassOf obo:HP_0031704, obo:HP_0046506 . obo:HP_0030767 obo:IAO_0000115 "Epignathus is a teratoma originating from the upper jaw, usually connected with the sphenoid bone or hard palate." ; oboInOwl:hasDbXref "SNOMEDCT_US:31248004", "UMLS:C0266725" ; oboInOwl:hasRelatedSynonym "Palatine teratoma" ; a owl:Class ; rdfs:label "Epignathus" ; rdfs:subClassOf obo:HP_0009792, obo:HP_0100649 . obo:HP_0030769 obo:IAO_0000115 "A malformation of the neural tube with a large amount of protruding brain tissue and absence of calvarium." ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:84461004", "UMLS:C0266453" ; a owl:Class ; rdfs:label "Exencephaly" ; rdfs:subClassOf obo:HP_0034237 . obo:HP_0030770 obo:IAO_0000115 "A neural tube defect in which both the brain and spinal cord remain open to varying degrees." ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:32219008", "UMLS:C0152426" ; a owl:Class ; rdfs:label "Craniorachischisis" ; rdfs:subClassOf obo:HP_0034237 . obo:HP_0030771 obo:IAO_0000115 "Mallet finger refers to a condition in which the end joint of a finger bends but will not straighten by itself. In this situation, the joint can be pushed straight but will not hold that position on its own." ; oboInOwl:hasDbXref "SNOMEDCT_US:64298006", "UMLS:C0158473" ; a owl:Class ; rdfs:label "Mallet finger" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0030772 obo:IAO_0000115 "Proximal femoral focal deficiency is a deformity manifested by hypoplasia of a variable portion of the femur with shortening of the entire limb." ; oboInOwl:hasDbXref "SNOMEDCT_US:205211001", "UMLS:C0431996" ; a owl:Class ; rdfs:label "Proximal femoral focal deficiency" ; rdfs:subClassOf obo:HP_0005613 . obo:HP_0030773 obo:IAO_0000115 "An abnormality of conjugate lateral gaze in which the affected eye shows impairment of adduction. The pathognomonic clinical sign of internuclear ophthalmoplegia is an impaired adduction while testing horizontal saccades on the side of the lesion in the ipsilateral medial longitudinal fascicule." ; oboInOwl:hasDbXref "MSH:D015835", "SNOMEDCT_US:49823009", "UMLS:C0152134" ; a owl:Class ; rdfs:label "Internuclear ophthalmoplegia" ; rdfs:subClassOf obo:HP_0000602 . obo:HP_0030774 obo:IAO_0000115 "The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures." ; oboInOwl:hasDbXref "MSH:D008933", "SNOMEDCT_US:125429001", "UMLS:C0026244" ; a owl:Class ; rdfs:label "Mitochondrial swelling" ; rdfs:subClassOf obo:HP_0012087 . obo:HP_0030775 obo:IAO_0000115 "An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic." ; oboInOwl:hasDbXref "UMLS:C4280778" ; a owl:Class ; rdfs:label "Modic type vertebral endplate changes" ; rdfs:subClassOf obo:HP_0003468 . obo:HP_0030776 obo:IAO_0000115 "An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation." ; oboInOwl:hasDbXref "UMLS:C4280777" ; oboInOwl:hasExactSynonym "Modic type 1 vertebral endplate changes" ; a owl:Class ; rdfs:label "Modic type I vertebral endplate changes" ; rdfs:subClassOf obo:HP_0030775 . obo:HP_0030777 obo:IAO_0000115 "An abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow." ; oboInOwl:hasDbXref "UMLS:C4280776" ; oboInOwl:hasExactSynonym "Modic type 2 vertebral endplate changes" ; a owl:Class ; rdfs:label "Modic type II vertebral endplate changes" ; rdfs:subClassOf obo:HP_0030775 . obo:HP_0030778 obo:IAO_0000115 "An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1 and T2-weighted sequences. Modic type III signals are thought to correspond to subchondral sclerosis seen on plain radiographs." ; oboInOwl:hasDbXref "UMLS:C4280775" ; oboInOwl:hasExactSynonym "Modic type 3 vertebral endplate changes" ; a owl:Class ; rdfs:label "Modic type III vertebral endplate changes" ; rdfs:subClassOf obo:HP_0030775 . obo:HP_0030779 obo:IAO_0000115 "Ethmocephaly is the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain. Clinically, the disease presents with a proboscis, hypotelorism, microphthalmos and malformed ears." ; oboInOwl:hasDbXref "SNOMEDCT_US:55709000", "UMLS:C0266680" ; a owl:Class ; rdfs:label "Ethmocephaly" ; rdfs:subClassOf obo:HP_0001360 . obo:HP_0030780 obo:IAO_0000115 "An anomaly of the protein C anticoagulant pathway, which serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. A natural anticoagulant system denoted the protein C pathway exerts its anticoagulant effect by regulating the activity of FVIIIa and FVa. The vitamin K-dependent protein C is the key component of the pathway. Activated protein C (APC) cleaves and inhibits coagulation cofactors FVIIIa and FVa, which result in downregulation of the activity of the coagulation system. The endothelial protein C receptor stimulates the T-TM-mediated activation of protein C on the endothelial cell surface. The two cofactors, protein S and the intact form of FV, enhance the anticoagulant activity of APC." ; oboInOwl:hasDbXref "UMLS:C4280774" ; a owl:Class ; rdfs:label "Abnormality of the protein C anticoagulant pathway" ; rdfs:subClassOf obo:HP_0003256 . obo:HP_0030781 obo:IAO_0000115 "A higher than normal levels of the fatty acids which can occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues." ; oboInOwl:hasDbXref "UMLS:C4280773" ; a owl:Class ; rdfs:label "Increased circulating free fatty acid level" ; rdfs:subClassOf obo:HP_0040300 . obo:HP_0030782 obo:IAO_0000115 "An abnormal amount of any of the interleukins, a class of cytokines, in the circulation." ; oboInOwl:hasDbXref "UMLS:C4280772" ; oboInOwl:hasExactSynonym "Abnormal serum IL level", "Abnormal serum interleukin level" ; a owl:Class ; rdfs:label "Abnormal circulating interleukin concentration" ; rdfs:subClassOf obo:HP_0011112 . obo:HP_0030783 obo:IAO_0000115 "An increased concentration of interleukin-6 in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C4280771" ; oboInOwl:hasExactSynonym "Increased serum IL-6", "Increased serum interleukin-6" ; a owl:Class ; rdfs:label "Increased circulating interleukin 6 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0030784 obo:IAO_0000115 "An inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name." ; oboInOwl:hasDbXref "MSH:D000849", "SNOMEDCT_US:10325006", "UMLS:C0003113" ; oboInOwl:hasExactSynonym "Amnesic aphasia", "Amnestic aphasia", "Anomia", "Nominal aphasia", "Word-finding difficulty" ; a owl:Class ; rdfs:label "Anomic aphasia" ; rdfs:subClassOf obo:HP_0002381 . obo:HP_0030785 obo:IAO_0000115 "A lymphangioma (congenital malformation consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures) located within the mediastinum, i.e., the central compartment of the thoracic cavity that is surrounded by loose connective tissue. Mediastinal lymphangioma is a slow growing mass with benign features, and accounts for 1% of all mediastinal tumors." ; oboInOwl:hasDbXref "UMLS:C4280770" ; oboInOwl:hasExactSynonym "Intrathoracic cystic hygroma", "Thoracic cystic lymphangioma" ; a owl:Class ; rdfs:label "Mediastinal cystic lymphangioma" ; rdfs:subClassOf obo:HP_0100764 . obo:HP_0030786 obo:IAO_0000115 "Perceived flashes of light." ; oboInOwl:hasDbXref "SNOMEDCT_US:56170001", "UMLS:C0085635" ; a owl:Class ; rdfs:comment "Photopsia may be associated with (1) posterior vitreous detachment, (2) migraine with aura, (3) migraine aura without headache, and (4) retinal break or detachment." ; rdfs:label "Photopsia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0030787 obo:IAO_0000115 "Any anomaly of the cerumen (ear wax), the yellowish waxy substance secreted in the ear canal." ; oboInOwl:hasDbXref "UMLS:C4280769" ; a owl:Class ; rdfs:label "Cerumen abnormality" ; rdfs:subClassOf obo:HP_0000372 . obo:HP_0030788 obo:IAO_0000115 "Blockage of the external auditory canal by a buildup of earwax." ; oboInOwl:hasDbXref "SNOMEDCT_US:18070006", "UMLS:C0021092" ; a owl:Class ; rdfs:label "Impacted cerumen" ; rdfs:subClassOf obo:HP_0030787 . obo:HP_0030789 obo:IAO_0000115 "An increased quantity of earwax." ; oboInOwl:hasDbXref "UMLS:C1382811" ; a owl:Class ; rdfs:comment "This feature is not necessarily associated with impacted cerumen, which if present should be coded separately." ; rdfs:label "Excessive cerumen" ; rdfs:subClassOf obo:HP_0030787 . obo:HP_0030790 obo:IAO_0000115 "An anomolous earwax color. Earwax (cerumen) is usually light to dark brown or orange in color." ; oboInOwl:hasDbXref "UMLS:C4280768" ; oboInOwl:hasExactSynonym "Abnormal cerumen colour", "Abnormal cerumen pigmentation" ; a owl:Class ; rdfs:label "Abnormal cerumen color" ; rdfs:subClassOf obo:HP_0030787 . obo:HP_0030791 obo:IAO_0000115 "A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla." ; oboInOwl:hasDbXref "UMLS:C4280767" ; a owl:Class ; rdfs:label "Abnormal jaw morphology" ; rdfs:subClassOf obo:HP_0011821 . obo:HP_0030792 obo:IAO_0000115 "A tumor originating in the jaw (mandible or maxilla)." ; oboInOwl:hasDbXref "MSH:D007573", "SNOMEDCT_US:126634001", "UMLS:C0022364" ; a owl:Class ; rdfs:label "Jaw neoplasm" ; rdfs:subClassOf obo:HP_0012289, obo:HP_0030791 . obo:HP_0030793 obo:IAO_0000115 "Abnormal enlargement in the upper jaw (maxilla) or in the lower jaw (mandible)." ; oboInOwl:hasDbXref "UMLS:C4280766" ; a owl:Class ; rdfs:label "Jaw swelling" ; rdfs:subClassOf obo:HP_0030791 . obo:HP_0030794 obo:IAO_0000115 "An anomolous circulating concentration of the connecting (C) peptide, which links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. After cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion." ; oboInOwl:hasDbXref "UMLS:C4280765" ; oboInOwl:hasExactSynonym "Abnormal C peptide level", "Abnormal C-peptide level" ; a owl:Class ; rdfs:label "Abnormal circulating C-peptide concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0030795 obo:IAO_0000115 "A decreased concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with reduced insulin secretion." ; oboInOwl:hasDbXref "UMLS:C4280764" ; oboInOwl:hasExactSynonym "Reduced C peptide level" ; a owl:Class ; rdfs:label "Reduced C-peptide level" ; rdfs:subClassOf obo:HP_0030794 . obo:HP_0030796 obo:IAO_0000115 "An elevated concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with increased insulin secretion." ; oboInOwl:hasDbXref "UMLS:C4280763" ; oboInOwl:hasExactSynonym "Increased C peptide level" ; a owl:Class ; rdfs:comment "C-peptide, which is composed of 31 amino acids, is released from the pancreatic beta-cells following cleavage of insulin from proinsulin. C-peptide levels are generally measured after an overnight fast." ; rdfs:label "Increased C-peptide level" ; rdfs:subClassOf obo:HP_0030794 . obo:HP_0030797 obo:IAO_0000115 "A diminished volume of the central part of the bed nucleus of the stria terminalis." ; oboInOwl:hasDbXref "UMLS:C4280762" ; a owl:Class ; rdfs:comment "This structure is larger in men than in females." ; rdfs:label "Reduced volume of central subdivision of bed nucleus of stria terminalis" ; rdfs:subClassOf obo:HP_0030798 . obo:HP_0030798 obo:IAO_0000115 "The stria terminalis is a slender, compact fiber bundle that connects the amygdala (amygdaloid body) with the hypothalamus and other basal forebrain regions. The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. This term refers to an anomaly of the bed nucleus." ; oboInOwl:hasDbXref "UMLS:C4280761" ; a owl:Class ; rdfs:label "Abnormality of the bed nucleus of stria terminalis" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0030799 obo:IAO_0000115 "Scaphocephaly is a subtype of dolichocephaly where the anterior and posterior aspects of the cranial vault are pointed (boat-shaped). Scaphocephaly is caused by a precocious fusion of sagittal suture without other associated synostosis." ; oboInOwl:hasDbXref "MSH:D003398", "SNOMEDCT_US:4191007", "UMLS:C0265534" ; a owl:Class ; rdfs:comment """Dolichocephaly is a term in wide use to describe any long narrow head, with a cephalic index usually below 75%. Scaphocephaly, derived from the Greek skaphe (a light boat or skiff), describes a specific variety of a long narrow head that resembles an inverted boat with a keel. Scaphocephaly thus refers to an inverted keellike appearance to the skull, with the widest part of the skull in the temporal rather than parietal area and with palpable ridging over part or all of the sagittal suture (PMID:16156241).""" ; rdfs:label "Scaphocephaly" ; rdfs:subClassOf obo:HP_0000268 . obo:HP_0030800 obo:IAO_0000115 "An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power." ; oboInOwl:hasDbXref "UMLS:C4280760" ; a owl:Class ; rdfs:label "Abnormal visual accommodation" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0030801 obo:IAO_0000115 "A decreased ability of the eye to adjust and thereby enable sharp vision of objects at different distances." ; oboInOwl:hasDbXref "UMLS:C4280759" ; a owl:Class ; rdfs:label "Reduced visual accommodation" ; rdfs:subClassOf obo:HP_0030800 . obo:HP_0030802 obo:IAO_0000115 "Inferior malposition of the lower eyelid margin without eyelid eversion." ; oboInOwl:hasDbXref "SNOMEDCT_US:700264006", "UMLS:C1861656" ; a owl:Class ; rdfs:comment "This is is not to be confused with ectropion (eyelid eversion). Lower eyelid retraction presents clinically with scleral show; round, sad-looking eyes; lateral canthal tendon laxity; and symptoms of ocular irritation, including photophobia, excessive tearing, and nocturnal lagophthalmos." ; rdfs:label "Lower eyelid retraction" ; rdfs:subClassOf obo:HP_0500043 . obo:HP_0030803 obo:IAO_0000115 "Abnormal flat nail." ; oboInOwl:hasDbXref "UMLS:C1853986" ; a owl:Class ; rdfs:label "Platonychia" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0030804 obo:IAO_0000115 "Excessive longitudinal ridging that gives the surface of the nail plate a rough appearance. It results from multiple foci of defective keratinization of the proximal nail matrix." ; oboInOwl:hasDbXref "SNOMEDCT_US:69192004", "UMLS:C0546956" ; a owl:Class ; rdfs:comment "The most common histopathologic findings of trachyonychia are spongiosis and exocytosis of inflammatory cells in the nail epithelia1. Although idiopathic trachyonychia may be much more common than reported, it may present with various associated skin or mucosal diseases including alopecia areata, lichen planus, psoriasis, and eczema. Trachyonychia predominantly occurs in children, although it can affect people of all ages. Trachyonychia can improve spontaneously but may have a chronic course exceeding 6 years and result in cosmetic handicaps." ; rdfs:label "Trachyonychia" ; rdfs:subClassOf obo:HP_0002164 . obo:HP_0030805 obo:IAO_0000115 "Lack of the lunula at the base of a nail. The lunula is the crescent-shaped whitish area of the bed of a fingernail or toenail." ; oboInOwl:hasDbXref "UMLS:C4280758" ; oboInOwl:hasExactSynonym "Absent lunulae", "Lunula absent", "Lunulae absent" ; a owl:Class ; rdfs:label "Absent lunula" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0030806 obo:IAO_0000115 "Nails whose growth is quicker than normal." ; oboInOwl:hasDbXref "UMLS:C4280757" ; a owl:Class ; rdfs:label "Fast-growing nails" ; rdfs:subClassOf obo:HP_0030807 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035878 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001705 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030807 obo:IAO_0000115 "Nail whose growth pattern or speed deviates from normal." ; oboInOwl:hasDbXref "UMLS:C1610609" ; a owl:Class ; rdfs:label "Abnormal nail growth" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035878 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001705 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030808 obo:IAO_0000115 "The cuticle (properly known as the eponychium, or the medial nail fold or the proximal nail fold), is the thickened layer of skin surrounding fingernails and toenails. Its function is to protect the area between the nail and epidermis from exposure to bacteria. This term refers to the presence of and irregular edge or outline of the cuticle." ; oboInOwl:hasDbXref "UMLS:C4280756" ; a owl:Class ; rdfs:label "Ragged cuticle" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0030809 obo:IAO_0000115 "Any structural anomaly of the tongue." ; oboInOwl:hasDbXref "UMLS:C4280755" ; a owl:Class ; rdfs:label "Abnormal tongue morphology" ; rdfs:subClassOf obo:HP_0000157 . obo:HP_0030810 obo:IAO_0000115 "Any functional anomaly of the tongue." ; oboInOwl:hasDbXref "UMLS:C4280754" ; a owl:Class ; rdfs:label "Abnormal tongue physiology" ; rdfs:subClassOf obo:HP_0000157 . obo:HP_0030811 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the tongue." ; oboInOwl:hasDbXref "MSH:D005926", "SNOMEDCT_US:30731004", "UMLS:C0017672" ; oboInOwl:hasExactSynonym "Painful tongue" ; a owl:Class ; rdfs:label "Tongue pain" ; rdfs:subClassOf obo:HP_0030810, obo:HP_0046506 . obo:HP_0030812 obo:IAO_0000115 "Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat." ; oboInOwl:hasDbXref "SNOMEDCT_US:46689006", "UMLS:C0272386" ; oboInOwl:hasExactSynonym "Enlargment of tonsils", "Tonsillar hypertrophy", "tonsils large/hypertrophy" ; a owl:Class ; rdfs:label "Enlarged tonsils" ; rdfs:subClassOf obo:HP_0100765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002372 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030813 obo:IAO_0000115 "Lack of observable tonsillar tissue." ; oboInOwl:hasDbXref "SNOMEDCT_US:249393008", "SNOMEDCT_US:300277007", "UMLS:C0576999" ; oboInOwl:hasExactSynonym "Hypoplastic tonsils", "Tonsillar hypoplasia" ; a owl:Class ; rdfs:label "Absent tonsils" ; rdfs:subClassOf obo:HP_0100765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002372 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030814 obo:IAO_0000115 "A phenomenon of orange colored oral tonsils. This feature is characteristic of Tangier disease and illustrated will by Figure 1 of PMID:19470903." ; oboInOwl:hasDbXref "UMLS:C4280753" ; oboInOwl:hasExactSynonym "Orange colored tonsils", "Orange coloured tonsils", "Orange discoloured tonsils", "Orange tonsils", "Tonsils with orange deposits" ; a owl:Class ; rdfs:label "Orange discolored tonsils" ; rdfs:subClassOf obo:HP_0100765 . obo:HP_0030815 obo:IAO_0000115 "A lipoma localized to the tongue. May present as a nontender, soft, spherical mass of the tongue." ; oboInOwl:hasDbXref "UMLS:C0238467" ; oboInOwl:hasExactSynonym "Tongue lipoma" ; a owl:Class ; rdfs:label "Lipoma of the tongue" ; rdfs:subClassOf obo:HP_0012032, obo:HP_0100648 . obo:HP_0030816 obo:IAO_0000115 "The loss of gum tissue. The result is that gum tissue is recessed and its position on the tooth is lowered, exposing the roots of the teeth." ; oboInOwl:hasDbXref "MSH:D005889", "SNOMEDCT_US:4356008", "UMLS:C0017572" ; oboInOwl:hasExactSynonym "Gum recession", "Receding gums" ; a owl:Class ; rdfs:label "Gingival recession" ; rdfs:subClassOf obo:HP_0000168 . obo:HP_0030817 obo:IAO_0000115 "Severe nail curvature, causing the tip of the nail to point downwards with respect to the axis of the finger. Beaked nails are caused by resorption of the distal digit." ; oboInOwl:hasDbXref "UMLS:C4280752" ; a owl:Class ; rdfs:comment "Beaked nails may be observed with conditions including hyperparathyroidism, renal failure, psoriasis, and systemic sclerosis." ; rdfs:label "Beaked nails" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0030818 obo:IAO_0000115 "The presence of a depressed line (\"canal\") in the center of the nail." ; oboInOwl:hasDbXref "SNOMEDCT_US:238718006", "SNOMEDCT_US:86393005", "UMLS:C0263526" ; oboInOwl:hasExactSynonym "Median nail dystrophy" ; a owl:Class ; rdfs:comment "Central nail canal may be observed with conditions including severe arterial disease, severe malnutrition, and repetitive trauma. Heller's fir tree deformity refers to a central canal with a fir tree appearanceand may occur with peripheral artery disease." ; rdfs:label "Central nail canal" ; rdfs:subClassOf obo:HP_0008404 . obo:HP_0030819 obo:IAO_0000115 "Nails that slope upward at the free edge." ; oboInOwl:hasDbXref "UMLS:C4280751" ; oboInOwl:hasExactSynonym "Upslanting nail", "Upward angulation of nail" ; a owl:Class ; rdfs:label "Ski jump nail" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0030820 obo:IAO_0000115 "Eyelid partly covered by skin when eyes are open." ; oboInOwl:hasDbXref "UMLS:C3277348" ; a owl:Class ; rdfs:label "Hooded eyelid" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0030821 obo:IAO_0000115 "Lower eyelid partly covered by skin when eyes are open." ; oboInOwl:hasDbXref "UMLS:C4280750" ; a owl:Class ; rdfs:label "Hooded lower eyelid" ; rdfs:subClassOf obo:HP_0030820 . obo:HP_0030822 obo:IAO_0000115 "Upper eyelid partly covered by skin when eyes are open." ; oboInOwl:hasDbXref "UMLS:C4280749" ; a owl:Class ; rdfs:label "Hooded upper eyelid" ; rdfs:subClassOf obo:HP_0030820 . obo:HP_0030823 obo:IAO_0000115 "Increased dimension of the sclera in the anterior-posterior axis." ; oboInOwl:hasDbXref "UMLS:C2674403" ; oboInOwl:hasExactSynonym "Thick sclera" ; a owl:Class ; rdfs:label "Scleral thickening" ; rdfs:subClassOf obo:HP_0000591 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001773 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030824 obo:IAO_0000115 "Change in the color of the fundus from red in the dark-adapted state to golden immediately or shortly after the onset of the light. The color of the fundus reflex in the light adapted state has also been described as golden-yellow, gray-white, and yellow-white. This reflex can appear either homogeneous or in streaks in the fundus. The retinal vessels appear to be protruding in contrast to the radiant background. Dark adaptation leads to disappearance of the unusual fundus coloration [Digital Journal of Ophthalmology 2008; Volume 14, Number 14]." ; oboInOwl:hasDbXref "UMLS:C4280748" ; oboInOwl:hasExactSynonym "Mizuo-Nakamura phenomenon" ; a owl:Class ; rdfs:label "Mizuo phenomenon" ; rdfs:subClassOf obo:HP_0001098 . obo:HP_0030825 obo:IAO_0000115 "Lack of the foveal reflex, which normally occurs as a result of the reflection of light from the ophthalmoscope in the foveal pit upon examination. The foveal reflex is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope." ; oboInOwl:hasDbXref "SNOMEDCT_US:247144003", "UMLS:C0423420" ; oboInOwl:hasExactSynonym "Foveal reflex absent", "Loss of foveal reflex" ; a owl:Class ; rdfs:comment "Absence of the foveal reflex can occur with macular edema, central serous retinopathy, or other macular abnormalities such as macular dystrophy. The macular reflex is often less pronounced in adults than in children, and may be absent in otherwise normal eyes of older individuals." ; rdfs:label "Absent foveal reflex" ; rdfs:subClassOf obo:HP_0000493 . obo:HP_0030826 obo:IAO_0000115 "Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching." ; oboInOwl:hasDbXref "UMLS:C4280682" ; oboInOwl:hasExactSynonym "Eyelid fluttering", "Fasciculation of the eyelid", "Muscle twitches in eye lid", "Muscle twitches in eyelid", "Twitching around eyes" ; a owl:Class ; rdfs:label "Eyelid fasciculation" ; rdfs:subClassOf obo:HP_0031785 . obo:HP_0030828 obo:IAO_0000115 "A high-pitched whistling sound associated with labored breathing." ; oboInOwl:hasDbXref "MSH:D012135", "SNOMEDCT_US:56018004", "UMLS:C0043144" ; oboInOwl:hasExactSynonym "Wheezing" ; a owl:Class ; rdfs:comment "Wheezes and rhonchi are continuous musical lung sounds. The American Thoracic Society (ATS) Committee on pulmonary nomenclature defines wheezes as high-pitched continuous sounds with a dominant frequency of 400 Hz or more, and rhonchi as low-pitched continuous musical sounds with a dominant frequency of about 200 Hz or less" ; rdfs:label "Wheezing" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0030829 obo:IAO_0000115 "An anomalous (adventitious) sound produced by the breathing process." ; oboInOwl:hasDbXref "SNOMEDCT_US:301273002", "UMLS:C0231856" ; oboInOwl:hasExactSynonym "Abnormal lung auscultation finding" ; a owl:Class ; rdfs:label "Abnormal breath sound" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0030830 obo:IAO_0000115 "Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position." ; oboInOwl:hasDbXref "MSH:D012135", "SNOMEDCT_US:48409008", "UMLS:C0034642" ; oboInOwl:hasExactSynonym "Crepitations", "Rales" ; a owl:Class ; rdfs:comment "Rales are fine, discontinuous crackles that can sound like cellophane being crumpled or velcro being pulled apart. They may be heard with a stethoscope when listening over lungs containing more than the normal amount of fluid secretiions." ; rdfs:label "Crackles" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0030831 obo:IAO_0000115 "Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds." ; oboInOwl:hasDbXref "MSH:D012135", "SNOMEDCT_US:24612001", "UMLS:C0035508" ; a owl:Class ; rdfs:comment "Wheezes and rhonchi are continuous musical lung sounds. The American Thoracic Society (ATS) Committee on pulmonary nomenclature defines wheezes as high-pitched continuous sounds with a dominant frequency of 400 Hz or more, and rhonchi as low-pitched continuous musical sounds with a dominant frequency of about 200 Hz or less." ; rdfs:label "Rhonchi" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0030832 obo:IAO_0000115 "Fiber- or rope-like opacities located within the vitreous humor." ; oboInOwl:hasDbXref "SNOMEDCT_US:28167005", "UMLS:C0271408" ; a owl:Class ; rdfs:label "Vitreous strands" ; rdfs:subClassOf obo:HP_0100832 . obo:HP_0030833 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck." ; oboInOwl:hasDbXref "MSH:D019547", "SNOMEDCT_US:81680005", "UMLS:C0007859" ; oboInOwl:hasExactSynonym "Neck pain" ; a owl:Class ; rdfs:label "Neck pain" ; rdfs:subClassOf obo:HP_0046506 . obo:HP_0030834 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder." ; oboInOwl:hasDbXref "MSH:D020069", "SNOMEDCT_US:45326000", "UMLS:C0037011" ; oboInOwl:hasExactSynonym "Shoulder pain" ; a owl:Class ; rdfs:label "Shoulder pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0030835 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow." ; oboInOwl:hasDbXref "SNOMEDCT_US:74323005", "UMLS:C0239266" ; oboInOwl:hasExactSynonym "Elbow pain" ; a owl:Class ; rdfs:label "Elbow pain" ; rdfs:subClassOf obo:HP_0012513 . obo:HP_0030836 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist." ; oboInOwl:hasDbXref "SNOMEDCT_US:202482009", "SNOMEDCT_US:56608008", "UMLS:C0221785" ; oboInOwl:hasExactSynonym "Wrist pain" ; a owl:Class ; rdfs:label "Wrist pain" ; rdfs:subClassOf obo:HP_0012513 . obo:HP_0030837 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger." ; oboInOwl:hasDbXref "SNOMEDCT_US:18876004", "UMLS:C0239589" ; oboInOwl:hasExactSynonym "Finger pain" ; a owl:Class ; rdfs:label "Finger pain" ; rdfs:subClassOf obo:HP_0046505 . obo:HP_0030838 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip." ; oboInOwl:hasDbXref "SNOMEDCT_US:49218002", "UMLS:C0019559" ; oboInOwl:hasExactSynonym "Hip pain" ; a owl:Class ; rdfs:label "Hip pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0030839 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee." ; oboInOwl:hasBroadSynonym "Pain under knee cap" ; oboInOwl:hasDbXref "SNOMEDCT_US:30989003", "UMLS:C0231749" ; oboInOwl:hasExactSynonym "Knee pain" ; a owl:Class ; rdfs:label "Knee pain" ; rdfs:subClassOf obo:HP_0012514 . obo:HP_0030840 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle." ; oboInOwl:hasDbXref "SNOMEDCT_US:202490009", "SNOMEDCT_US:247373008", "UMLS:C0238656" ; oboInOwl:hasExactSynonym "Ankle pain" ; a owl:Class ; rdfs:label "Ankle pain" ; rdfs:subClassOf obo:HP_0012514 . obo:HP_0030841 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe." ; oboInOwl:hasDbXref "SNOMEDCT_US:285365001", "UMLS:C0241416" ; oboInOwl:hasExactSynonym "Toe pain" ; a owl:Class ; rdfs:label "Toe pain" ; rdfs:subClassOf obo:HP_0012514 . obo:HP_0030842 obo:IAO_0000115 "Incidents in which a piece of food or other objects get stuck in the upper airway and provoke coughing, gagging, inability to talk, and difficulty breathing." ; oboInOwl:hasDbXref "UMLS:C4280747" ; a owl:Class ; rdfs:label "Choking episodes" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0030843 obo:IAO_0000115 "Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding." ; oboInOwl:hasAlternativeId "HP:0200126" ; oboInOwl:hasDbXref "SNOMEDCT_US:16573007", "UMLS:C0268407" ; oboInOwl:hasExactSynonym "Amyloid cardiomyopathy" ; a owl:Class ; rdfs:comment "The diagnosis of amyloidosis requires histological identification of amyloid deposits. Congo Red staining renders amyloid deposits salmon pink by light microscopy, with a characteristic apple green birefringence under polarized light conditions. Additional immunohistochemical staining for precursor proteins identifies the type of amyloidosis." ; rdfs:label "Cardiac amyloidosis" ; rdfs:subClassOf obo:HP_0001637, obo:HP_0011034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_34 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030844 obo:IAO_0000115 "Absent response to a pattern electroretinogram (PERG)." ; oboInOwl:hasDbXref "UMLS:C4280746" ; a owl:Class ; rdfs:label "Undetectable pattern electroretinogram" ; rdfs:subClassOf obo:HP_0030467 . obo:HP_0030845 obo:IAO_0000115 "Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema." ; oboInOwl:hasDbXref "UMLS:C4280745" ; a owl:Class ; rdfs:comment "Purple eyelids, which are described as heliotrope, as they resemble the heliotrope flower, e.g., Heliotropium peruvianum, which has small purple petals. Heliotrope rash is one of the characteristic skin manifestations of juvenile dermatomyositis. It is a reddish-purple rash on the upper eyelids that is usually bilateral." ; rdfs:label "Heliotrope rash of eyelid" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0040324 . obo:HP_0030846 obo:IAO_0000115 "An anomaly of venous function." ; oboInOwl:hasDbXref "UMLS:C4280744" ; a owl:Class ; rdfs:label "Abnormality of venous physiology" ; rdfs:subClassOf obo:HP_0030163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030847 obo:IAO_0000115 "An anomaly of the jugular venous pressure. The internal jugular veins, being continuous with the superior vena cava, provide a visible measure of the degree to which the systemic venous reservoir is filled. The vertical height above the right atrium to which they are distended and above which they are in a collapsed state provides an imperfect reflection of the right atrial pressure." ; oboInOwl:hasDbXref "SNOMEDCT_US:62436006", "UMLS:C0520860" ; a owl:Class ; rdfs:label "Abnormal jugular venous pressure" ; rdfs:subClassOf obo:HP_0030846 . obo:HP_0030848 obo:IAO_0000115 "Increased jugular venous pressure." ; oboInOwl:hasDbXref "SNOMEDCT_US:22447003", "UMLS:C0520861" ; a owl:Class ; rdfs:label "Elevated jugular venous pressure" ; rdfs:subClassOf obo:HP_0030847 . obo:HP_0030849 obo:IAO_0000115 "The examiner applies firm but persistent pressure over the liver for 10 seconds while observing the mean jugular venous pressure. Normally there is either no rise or only a transient (i.e., 2 to 3 sec) rise in mean jugular venous pressure. A sustained increase in the mean venous pressure until abdominal compression is released is abnormal and indicates impaired right heart function. This abnormal response is called hepatojugular reflux." ; oboInOwl:hasDbXref "SNOMEDCT_US:72196001", "UMLS:C0239949" ; a owl:Class ; rdfs:label "Hepatojugular reflux" ; rdfs:subClassOf obo:HP_0030847 . obo:HP_0030850 obo:IAO_0000115 "An anomaly of the pulse pressure, which is defined as the systolic pressured minus the diastolic pressure." ; oboInOwl:hasDbXref "UMLS:C0855322" ; a owl:Class ; rdfs:label "Abnormal pulse pressure" ; rdfs:subClassOf obo:HP_0030163 . obo:HP_0030851 obo:IAO_0000115 "Reduced amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure)." ; oboInOwl:hasDbXref "UMLS:C4280743" ; a owl:Class ; rdfs:label "Low pulse pressure" ; rdfs:subClassOf obo:HP_0030850 . obo:HP_0030852 obo:IAO_0000115 "Increased amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure)." ; oboInOwl:hasDbXref "UMLS:C0855323" ; a owl:Class ; rdfs:label "High pulse pressure" ; rdfs:subClassOf obo:HP_0030850 . obo:HP_0030853 obo:IAO_0000115 "An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body." ; oboInOwl:hasDbXref "Fyler:0190", "Fyler:190", "MSH:D059446", "SNOMEDCT_US:14821001", "SNOMEDCT_US:24614000", "UMLS:C0266642" ; oboInOwl:hasExactSynonym "Heterotaxia" ; a owl:Class ; rdfs:comment "In the normal body, the internal organs are arranged in different patterns on the right and left sides, and are not mirror images of each other. Hence, if asymmetry of the thoracic and abdominal organs is the usual or normal situation, the syndrome of visceral heterotaxy includes patients with an unusual degree of symmetry of some of the thoracic and abdominal organs, and the atrial appendages within the heart." ; rdfs:label "Heterotaxy" ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0030854 obo:IAO_0000115 "A staphyloma is a localized defect in the eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." ; oboInOwl:hasDbXref "SNOMEDCT_US:111534007", "UMLS:C0155359" ; oboInOwl:hasExactSynonym "Staphyloma" ; a owl:Class ; rdfs:comment "Most staphylomas occur in the posterior pole, usually due to pathological or degenerative myopia. Anterior staphylomas are less frequent. They generally occur after longstanding mistreated or untreated infections in a previously healthy eye and are commonly associated with fungal corneal ulcers. In other cases, they may follow chronic inflammatory diseases such as necrotizing scleritis." ; rdfs:label "Scleral staphyloma" ; rdfs:subClassOf obo:HP_0000591 . obo:HP_0030855 obo:IAO_0000115 "A localized defect in the anterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." ; oboInOwl:hasDbXref "SNOMEDCT_US:231888000", "UMLS:C0339206" ; a owl:Class ; rdfs:label "Anterior staphyloma" ; rdfs:subClassOf obo:HP_0030854 . obo:HP_0030856 obo:IAO_0000115 "A localized defect in the posterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." ; oboInOwl:hasDbXref "SNOMEDCT_US:87819007", "UMLS:C0155360" ; a owl:Class ; rdfs:label "Posterior staphyloma" ; rdfs:subClassOf obo:HP_0030854 . obo:HP_0030857 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye that is worse in certain directions of gaze and during prolonged gaze holding." ; oboInOwl:hasDbXref "UMLS:C4280742" ; a owl:Class ; rdfs:label "Eye movement-induced pain" ; rdfs:subClassOf obo:HP_0200026 . obo:HP_0030858 obo:IAO_0000115 "When an activity, substance, object, or behavior becomes a major focus of a person's life excluding other activities, or has begun to harm the individual or others physically, mentally, or socially can be considered addictive behavior. A person can become addicted or compulsively engaged with anything." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "MSH:D016739", "SNOMEDCT_US:32709003", "UMLS:C0085281" ; oboInOwl:hasExactSynonym "Addictive behaviour" ; a owl:Class ; rdfs:comment "Several behaviors, besides psychoactive substance ingestion, produce short-term rewards that may engender persistent behavior despite knowledge of adverse consequences, i.e., diminished control over the behavior." ; rdfs:label "Addictive behavior" ; rdfs:subClassOf obo:HP_5200045 . obo:HP_0030859 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against topoisomerase I." ; oboInOwl:hasDbXref "UMLS:C4280741" ; oboInOwl:hasExactSynonym "Anti-Scl-70 antibody positivity", "Top1 antibody positivity", "Topoisomerase (DNA) I antibody positivity" ; a owl:Class ; rdfs:comment "Anti-topoisomerase I antibodies are classically associated with interstitial lung disease (ILD) and the diffuse cutaneous form of systemic sclerosis." ; rdfs:label "Anti-topoisomerase I antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0030860 obo:IAO_0000115 "Abnormal concentration of amyloid in the cerebrospinal fluid (CSF)." ; oboInOwl:hasDbXref "UMLS:C4280740" ; oboInOwl:hasExactSynonym "Abnormal CSF A[beta]42 level", "Abnormal CSF amyloid level" ; a owl:Class ; rdfs:comment "In Alzheimer disease, histopathology typically reveals extracellular accumulations of amyloid beta (Abeta) in senile plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau (P-tau). A[beta]42 is the 42 amino acid isoform of amyloid beta. Using positron emission tomography several studies found an inverse correlation between brain amyloid load and CSF A[beta]42." ; rdfs:label "Abnormal CSF amyloid concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0030861 obo:IAO_0000115 "Reduced concentration of amyloid in the cerebrospinal fluid (CSF)." ; oboInOwl:hasDbXref "UMLS:C4280739" ; oboInOwl:hasExactSynonym "Decreased CSF amyloid level" ; a owl:Class ; rdfs:label "Decreased CSF amyloid concentration" ; rdfs:subClassOf obo:HP_0030860 . obo:HP_0030862 obo:IAO_0000115 "Increased concentration of amyloid in the cerebrospinal fluid (CSF)." ; oboInOwl:hasDbXref "UMLS:C4280738" ; oboInOwl:hasExactSynonym "Elevated CSF amyloid level" ; a owl:Class ; rdfs:label "Elevated CSF amyloid concentration" ; rdfs:subClassOf obo:HP_0030860 . obo:HP_0030863 obo:IAO_0000115 "Widening of the nostrils upon inhalation as a manifestation of respiratory distress." ; oboInOwl:hasDbXref "SNOMEDCT_US:21558008", "SNOMEDCT_US:248568003", "UMLS:C0277873" ; a owl:Class ; rdfs:comment "Nasal flaring is a compensatory symptom that increases upper airway diameter and reduces resistance and work of breathing." ; rdfs:label "Nasal flaring" ; rdfs:subClassOf obo:HP_0002098 . obo:HP_0030864 obo:IAO_0000115 "A pulling inward of the soft tissues between the ribs upon inhalation. This is a sign of increased use of the chest muscles for breathing and is a manifestation of respiratory distress." ; oboInOwl:hasDbXref "SNOMEDCT_US:6442005", "UMLS:C0425470" ; oboInOwl:hasExactSynonym "Chest retractions" ; a owl:Class ; rdfs:label "Intercostal retractions" ; rdfs:subClassOf obo:HP_0002098 . obo:HP_0030865 obo:IAO_0000115 "Abnormal increased size of the elbow joint." ; oboInOwl:hasDbXref "UMLS:C4280737" ; oboInOwl:hasExactSynonym "Prominent elbow" ; a owl:Class ; rdfs:label "Large elbow" ; rdfs:subClassOf obo:HP_0009811 . obo:HP_0030866 obo:IAO_0000115 "Abnormally increased size of the knee joint." ; oboInOwl:hasDbXref "UMLS:C4280736" ; a owl:Class ; rdfs:label "Large knee" ; rdfs:subClassOf obo:HP_0034669 . obo:HP_0030867 obo:IAO_0000115 "The orbits do not lie on the same horizontal plane, that is, one eye is lower than the other." ; oboInOwl:hasDbXref "SNOMEDCT_US:253243008", "UMLS:C0431460" ; oboInOwl:hasExactSynonym "Eyes at different heights", "Misaligned eyes", "Unequal eye height" ; a owl:Class ; rdfs:label "Vertical orbital dystopia" ; rdfs:subClassOf obo:HP_0100886 . obo:HP_0030868 obo:IAO_0000115 "Having only one testis in the scrotum." ; oboInOwl:hasDbXref "SNOMEDCT_US:87310001", "UMLS:C0266429" ; oboInOwl:hasExactSynonym "Monorchidism" ; a owl:Class ; rdfs:label "Monorchism" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0030869 obo:IAO_0000115 "An abnormality of XY sexual development characterized by the absence of both testes at birth." ; oboInOwl:hasDbXref "MSH:C537770", "SNOMEDCT_US:371015003", "UMLS:C1261504" ; a owl:Class ; rdfs:label "Anorchism" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0030870 obo:IAO_0000115 "An anomaly of the small joints located between and behind adjacent vertebrae." ; oboInOwl:hasDbXref "UMLS:C4280735" ; oboInOwl:hasExactSynonym "Abnormality of Z-joint", "Abnormality of apophyseal joint", "Abnormality of zygapophyseal joint", "Abnormality of zygapophysial joint" ; a owl:Class ; rdfs:comment "The spinal facet joints represent a set of synovial, plane joints between the articular processes of each two adjacent vertebrae. Each pair of facet joints functions to guide and limit the movement of the corresponding spinal motion segment." ; rdfs:label "Abnormality of spinal facet joint" ; rdfs:subClassOf obo:HP_0003312 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030871 obo:IAO_0000115 "Osteoarthritis of facet joints in the spine. Degeneration of cartilage in the facet joints results in bone rubbing on bone and reactive new bone formation visible on X-ray." ; oboInOwl:hasDbXref "UMLS:C4280734" ; oboInOwl:hasExactSynonym "Facet arthritis" ; a owl:Class ; rdfs:comment "Facet joint osteoarthritis (FJ OA) is intimately linked to degenerative disc disease, which affects structures in the anterior aspect of the vertebral column. FJ OA and degenerative disc disease are both common causes of back and neck pain." ; rdfs:label "Facet joint arthrosis" ; rdfs:subClassOf obo:HP_0030870 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0002758 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030872 obo:IAO_0000115 "An abnormality of the cardiac ventricular function." ; oboInOwl:hasDbXref "UMLS:C4280733" ; a owl:Class ; rdfs:label "Abnormal cardiac ventricular function" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0030873 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against the centromeres or centromere components." ; oboInOwl:hasDbXref "UMLS:C4280732" ; oboInOwl:hasExactSynonym "ACA positivity", "Anticentromere antibody positivity" ; a owl:Class ; rdfs:comment "Anti-centromere antibodies are typically associated with pulmonary arterial hypertension and the limited cutaneous form of systemic sclerosis." ; rdfs:label "Anti-centromere antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0030874 obo:IAO_0000115 "Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa." ; oboInOwl:hasDbXref "UMLS:C4280731" ; oboInOwl:hasExactSynonym "O2 desaturation on exertion" ; a owl:Class ; rdfs:label "Oxygen desaturation on exertion" ; rdfs:subClassOf obo:HP_0012418 . obo:HP_0030875 obo:IAO_0000115 "A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart." ; oboInOwl:hasDbXref "UMLS:C4280730" ; oboInOwl:hasExactSynonym "Abnormal pulmonary circulation", "Abnormality of respiratory circulation" ; a owl:Class ; rdfs:label "Abnormality of pulmonary circulation" ; rdfs:subClassOf obo:HP_0002795, obo:HP_0030163 . obo:HP_0030876 obo:IAO_0000115 "Pulmonary capillary wedge pressure (PCWP) above 15mmHg." ; oboInOwl:hasDbXref "SNOMEDCT_US:30261008", "UMLS:C0520850" ; oboInOwl:hasExactSynonym "Increased pulmonary arterial wedge pressure", "Increased pulmonary artery occlusion pressure" ; a owl:Class ; rdfs:comment "The pulmonary capillary wedge pressure refers to the pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch." ; rdfs:label "Increased pulmonary capillary wedge pressure" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0030877 obo:IAO_0000115 "Abnormally low FEV1/FVC (FEV1 - forced expiratory volume in 1 second; FVC forced vital capacity)." ; oboInOwl:hasDbXref "UMLS:C4280729" ; oboInOwl:hasExactSynonym "Obstructive deficit on pulmonary function test", "Obstructive deficit on pulmonary function testing" ; a owl:Class ; rdfs:comment "A low FEV1/FVC ratio indicates an obstructive defect. There are several cutoffs in the literature. The first option is to follow the GOLD criteria, which use a cutoff of less than 70 percent. For patients five to 18 years of age, the National Asthma Education and Prevention Program guideline says that a ratio of less than 85 percent is consistent with an obstructive defect as long as the patient has symptoms consistent with obstructive lung disease. The second option is to follow the ATS criteria, which use the lower limit of normal (LLN) as the cutoff for adults. The LLN is a measurement less than the fifth percentile of spirometry data obtained from the Third National Health and Nutrition Examination Survey (NHANES III)." ; rdfs:label "Reduced FEV1/FVC ratio" ; rdfs:subClassOf obo:HP_0006536, obo:HP_0030878 . obo:HP_0030878 obo:IAO_0000115 "Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography." ; oboInOwl:hasAlternativeId "HP:0032340" ; oboInOwl:hasDbXref "UMLS:C4280728" ; oboInOwl:hasExactSynonym "Abnormal pulmonary function test" ; oboInOwl:hasRelatedSynonym "Abnormal spirometry test" ; a owl:Class ; rdfs:label "Abnormality on pulmonary function testing" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0030879 obo:IAO_0000115 "Presence of thickening of the interlobular septa of the lungs as seen on a CT scan." ; oboInOwl:hasDbXref "UMLS:C4280727" ; oboInOwl:hasExactSynonym "Interlobular lines (pulmonary CT finding)", "Peripheral lines (pulmonary CT finding)", "Septal lines (pulmonary CT finding)", "Septal thickening (pulmonary CT finding)", "Short lines (pumonary CT finding)" ; oboInOwl:hasNarrowSynonym "Interlobular septal thickening on pulmonary HRCT" ; a owl:Class ; rdfs:comment "Interlobular septa are 10-20nm long structures at the border of the secondary pulmonary lobules and which are usually perpendicular to the pleura in the periphery of the lung. Interlobular septa are composed of connective tissue and contain pulmonary venules and lymphatics. Diseases that affect one of the components of the interlobular septa may lead to thickening of the septa, which makes the visible on computed tomography (CT) scans. Some of the diseases that may be associated with this phenotypic feature are pulmonary edema, pulmonary lymphangitis carcinomatosis, leukemic or lymphomic involvement of the lung, diffuse alveolar hemorrhage, Nieman-Pick disease, and pneumonia." ; rdfs:label "Interlobular septal thickening" ; rdfs:subClassOf obo:HP_0033711 . obo:HP_0030880 oboInOwl:hasDbXref "MSH:D011928", "SNOMEDCT_US:266261006", "UMLS:C0034735" ; oboInOwl:hasExactSynonym "Raynaud's phenomenon" ; oboInOwl:hasRelatedSynonym "Raynaud disease" ; a owl:Class ; rdfs:comment "Excessively reduced blood flow in response to cold or emotional stress, causing discolouration of the fingers, toes." ; rdfs:label "Raynaud phenomenon" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0030881 obo:IAO_0000115 "Trapping and compression of the rotator cuff tendons during shoulder movements." ; oboInOwl:hasDbXref "UMLS:C1655733" ; a owl:Class ; rdfs:comment "Shoulder impingment can cause the rotator cuff tendon to become inflamed and swollen (rotator cuff tendonitis). Similarly, shoulder impingement can cause the bursa to become inflamed (shoulder bursitis)." ; rdfs:label "Shoulder impingement" ; rdfs:subClassOf obo:HP_0033129 . obo:HP_0030882 obo:IAO_0000115 "Enlargement of the diameter (cross-section) of a coronary artery as defined by a focal dilation of a segment at least 1.5 times larger than the reference vessel." ; oboInOwl:hasDbXref "Fyler:3129", "UMLS:C4255100" ; oboInOwl:hasExactSynonym "Coronary arterial dilatation", "Coronary artery dilatation", "Coronary artery ectasia" ; a owl:Class ; rdfs:label "Coronary artery aneurysm" ; rdfs:subClassOf obo:HP_0006704 . obo:HP_0030883 obo:IAO_0000115 "Femoroacetabular impingement (FAI) results from one or more bony abnormalities that lead to abnormal contact between the acetabulum and the femoral head or neck. The femoral abnormality is proposed to cause compression and shear stresses in the region between the labrum and cartilage, anterosuperiorly. These stresses cause a separation between the labrum and cartilage as the labrum is pushed outwards and the cartilage is pushed centrally. This eventually leads to articular degeneration and eventually global hip osteoarthritis." ; oboInOwl:hasDbXref "MSH:D057925", "SNOMEDCT_US:432473000", "UMLS:C2936290" ; oboInOwl:hasExactSynonym "Femoral acetabular impingement" ; a owl:Class ; rdfs:label "Femoroacetabular impingement" ; rdfs:subClassOf obo:HP_0001384 . obo:HP_0030884 obo:IAO_0000115 "Feeding problem necessitating gastrojejunal tube feeding." ; oboInOwl:hasDbXref "UMLS:C4280681" ; oboInOwl:hasExactSynonym "Gastro-jejunal tube feeding in infancy" ; a owl:Class ; rdfs:comment "The rationale for gastrojejunal tube feeding is that placing the tip of the tube beyond the ligament of Treitz prevented duodenogastric reflux or gastro-esophageal reflux. Gastrojejunal feeding tubes have since been used in children who are deemed too unfit for antireflux surgery or where fundoplication has failed." ; rdfs:label "Gastrojejunal tube feeding in infancy" ; rdfs:subClassOf obo:HP_0008872, obo:HP_0033454 . obo:HP_0030885 obo:IAO_0000115 "Increased susceptibility to parasitic infections, as manifested by recurrent episodes of parasitic infection." ; oboInOwl:hasDbXref "UMLS:C4280726" ; a owl:Class ; rdfs:label "Recurrent parasitic infections" ; rdfs:subClassOf obo:HP_0002719, obo:HP_0020108 . obo:HP_0030886 obo:IAO_0000115 "A anomaly in the rate of programmed cell death (apoptosis) in lymphocytes." ; oboInOwl:hasDbXref "UMLS:C4280725" ; a owl:Class ; rdfs:label "Abnormal lymphocyte apoptosis" ; rdfs:subClassOf obo:HP_0031409 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070227 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030887 obo:IAO_0000115 "A elevation in the rate of apoptosis in lymphocytes." ; oboInOwl:hasDbXref "UMLS:C4280724" ; a owl:Class ; rdfs:label "Increased lymphocyte apoptosis" ; rdfs:subClassOf obo:HP_0030886 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0070227 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030888 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against C3 convertase (C3bBb)." ; a owl:Class ; rdfs:label "C3 nephritic factor positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030889 obo:IAO_0000115 "Substantially shortened length of the small intestine as a result of a developmental defect." ; oboInOwl:hasRelatedSynonym "Short bowel" ; a owl:Class ; rdfs:comment "The mean length of the small intestine in full-term newborns is approximately 240 cm, increasing to 430 cm by 15 years of age. In adults, the average small bowel length is reported to be 600 cm, with a range of 260 cm to 800 cm. Short bowel syndrome (SBS) is a clinical disorder that is characterized by diarrhea and malabsorption following the functional or anatomical loss of enough small bowel length to markedly compromise intestinal absorptive capacity. SBS may result from from surgical resection, congenital defect, or disease-associated loss of absorption. This term describes congenital shortening of the small intestine that is one phenotypic feature of SBS." ; rdfs:label "Congenital shortened small intestine" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0030890 obo:IAO_0000115 "A brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter." ; dcterms:creator ; oboInOwl:hasExactSynonym "White matter hyperintensity" ; a owl:Class ; rdfs:label "Hyperintensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0030891 obo:IAO_0000115 "Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles." ; dcterms:creator ; oboInOwl:hasExactSynonym "PVWMH" ; a owl:Class ; rdfs:comment "See also defintion for \"Deep cerebral white matter hyperintensities\". These two entities are in contra-distinction to each other." ; rdfs:label "Periventricular white matter hyperintensities" ; rdfs:subClassOf obo:HP_0002518, obo:HP_0030890 . obo:HP_0030892 obo:IAO_0000115 "Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system." ; dcterms:creator ; oboInOwl:hasExactSynonym "DWMH" ; a owl:Class ; rdfs:comment "See also defintion for \"Periventricular white matter hyperintensities\". These two entities are in contra-distinction to each other." ; rdfs:label "Deep cerebral white matter hyperintensities" ; rdfs:subClassOf obo:HP_0030890 . obo:HP_0030893 obo:IAO_0000115 "Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg." ; a owl:Class ; rdfs:label "Abnormal response to short acting pulmonary vasodilator" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0030894 obo:IAO_0000115 "No fall in mean pulmonary arterial pressure (mPAP) falls by at least 10 mmHg to an absolute value less than 40 mmHg without a degradation in cardiac output (CO) in response to a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide." ; a owl:Class ; rdfs:label "Insufficient response to short acting pulmonary vasodilator" ; rdfs:subClassOf obo:HP_0030893 . obo:HP_0030895 obo:IAO_0000115 "An anomaly of the muscular contractions that propel food though the gastrointestinal tract." ; oboInOwl:hasExactSynonym "Abnormal GI motility" ; a owl:Class ; rdfs:label "Abnormal gastrointestinal motility" ; rdfs:subClassOf obo:HP_0012719 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0014831 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030896 obo:IAO_0000115 "A deviation from the normal amount of time required for food to pass through the intestines." ; oboInOwl:hasExactSynonym "Abnormal GI transit time" ; a owl:Class ; rdfs:comment "Gastrointestinal motility is usually described in terms of regional transit times or as intraluminal pressure changes. Scintigraphy is the gold standard for determination of gastric emptying and small intestinal transit" ; rdfs:label "Abnormal gastrointestinal transit time" ; rdfs:subClassOf obo:HP_0030895 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001309 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0120054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030897 obo:IAO_0000115 "A reduction in the length of time required for food to pass through the intestines." ; a owl:Class ; rdfs:label "Decreased intestinal transit time" ; rdfs:subClassOf obo:HP_0030896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000499 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0120054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030898 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the abdomen." ; a owl:Class ; rdfs:label "Pruritis on abdomen" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0030899 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the hand." ; a owl:Class ; rdfs:label "Pruritis on hand" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0030900 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the foot." ; oboInOwl:hasExactSynonym "Itchy feet", "Itchy foot" ; a owl:Class ; rdfs:label "Pruritus on foot" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0030901 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the breast." ; a owl:Class ; rdfs:label "Pruritis on breast" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0030902 obo:IAO_0000115 "A type of primitive reflex characterized by an involuntary contraction of the mentalis muscle of the chin caused by stimulation of the thenar eminence of the palm." ; a owl:Class ; rdfs:comment "The palmomental reflex is often present in normal people and may be absent in disease states. Testing merely for the presence or absence of the reflex therefore lacks both specificity and sensitivity. A strong, sustained, and easily repeatable contraction of the mentalis muscle, which can be elicited by stimulation of areas other than the palm, is more likely to indicate cerebral damage." ; rdfs:label "Palmomental reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0030903 obo:IAO_0000115 "A type of primitive reflex that can be elicated when the hand of the examiner is gently inserted into the palm of the patient's hand. The palmar surface is stroked or simply touched. The flexor surfaces of the fingers may be stimulated also by the examiner's fingers. The stimulus should be in a distal direction. With a positive response, the patient grasps the examiner's hand with variable strength and continues to grasp as the examiner's hand is moved. Ability to release the grip voluntarily depends on the activity of the reflex; some patients can do so readily, while others can even be lifted off the bed, since the grasp has such power [NCBI Books:NBK395]." ; oboInOwl:hasExactSynonym "Palmar grasp reflex" ; a owl:Class ; rdfs:label "Grasp reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0030904 obo:IAO_0000115 "A type of primitive reflex that is elicited by repetitive tapping on the forehead. Normal subjects usually blink in response to the first several taps, but if blinking persists, the response is abnormal and considered to be a sign of frontal release. Persistent blinking is also known as Myerson's sign." ; oboInOwl:hasRelatedSynonym "Myerson's sign" ; a owl:Class ; rdfs:label "Glabellar reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0030905 obo:IAO_0000115 "A type of primitive reflex that is elicited by tapping the upper lip lightly. The contraction of the muscles causes the mouth to resemble a snout." ; a owl:Class ; rdfs:label "Snout reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0030906 obo:IAO_0000115 "A type of primitive reflex that is elicited by lightly touching or tapping on the lips with an object such as a tongue blade, reflex hammer, or the examiner's finger. At times the reflex is obtained merely by approaching the lips with an object. A positive suck reflex consists of sucking movements by the lips when they are stroked or touched." ; oboInOwl:hasExactSynonym "Persistent nutritive suckle swallow" ; a owl:Class ; rdfs:label "Suck reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0030907 obo:IAO_0000115 "Severe head pain with sudden onset, reaching its maximum intensity in less than one minute and lasting from one hour to ten days." ; a owl:Class ; rdfs:comment "The differential diagnosis of thunderclap headache (TCH) includes subarachnoid hemorrhage, ischemic stroke, cerebral venous thrombosis, cervical arterial dissection, acute hypertensive crisis, retroclival hematoma, pituitary apoplexy, and pheochromocytoma." ; rdfs:label "Thunderclap headache" ; rdfs:subClassOf obo:HP_0002315 . obo:HP_0030908 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2)." ; oboInOwl:hasAlternativeId "HP:0034113" ; oboInOwl:hasExactSynonym "Anti-LKM-1 positive", "Anti-LKM1 antibody positivity", "Anti-liver kidney microsomal type 1 antibody positivity", "Anti-type I liver-kidney microsomal antibody positivity" ; a owl:Class ; rdfs:comment "LKM1 is conventionally detected by immunofluorescence (IFL), a subjective technique, using rat liver, kidney, and stomach as a composite substrate." ; rdfs:label "Liver kidney microsome type 1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030909 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against a 60-kd peptide contained in the liver cytosolic fraction." ; oboInOwl:hasExactSynonym "Anti-liver cytosol antibody-1 positivity" ; a owl:Class ; rdfs:comment "These autoantibodies may be observed in a subset of persons with autoimmune hepatitis." ; rdfs:label "Anti-liver cytosolic antigen type 1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0030911 obo:IAO_0000115 "Two clitorides located side by side." ; a owl:Class ; rdfs:comment "The word bifid indicates the presence of a split clitoris, as opposed to a supernumerary clitoris, which could be described as Duplicated clitoris. A bifid clitoris is almost invariably accompanied by Epispadias, which should be coded separately." ; rdfs:label "Bifid clitoris" ; rdfs:subClassOf obo:HP_0000056 . obo:HP_0030912 obo:IAO_0000115 "Supernumerary clitoris." ; a owl:Class ; rdfs:comment "The word bifid indicates the presence of a split clitoris, as opposed to a supernumerary clitoris, which could be described as duplicated clitoris." ; rdfs:label "Duplicated clitoris" ; rdfs:subClassOf obo:HP_0000056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030913 obo:IAO_0000115 "Marked rugae formation of the skin of the labia majora." ; oboInOwl:hasExactSynonym "Scrotum-like labia majora" ; a owl:Class ; rdfs:comment "Some rugae formation is typically found on the labia majora, but less than on the scrotum." ; rdfs:label "Exaggerated rugosity of the labia majora" ; rdfs:subClassOf obo:HP_0012881 . obo:HP_0030914 obo:IAO_0000115 "An anomaly of the wave-like muscle contractions of the digestive tract." ; a owl:Class ; rdfs:label "Abnormal peristalsis" ; rdfs:subClassOf obo:HP_0002579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030432 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030915 obo:IAO_0000115 "Swelling from fluid accumulation (serous fluid infiltration into the interstitial space) in the cerebellum." ; dcterms:creator ; oboInOwl:hasExactSynonym "Cerebellar oedema", "Edema of the cerebellum", "Oedema of the cerebellum" ; a owl:Class ; rdfs:comment "Cerebellar edama can manifest on magnetic resonance imaging as hyperintense T2 and FLAIR signals, which do not show restricted diffusion." ; rdfs:label "Cerebellar edema" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0030917 dc:date "2016-11-07T18:06:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The APGAR score was developed by Dr. Virginia Apgar to quickly assess the status of newborn children. It is determined based on scoing five criteria (Appearance, Pulse, Grimace, Activity, Respiration) on a scale of zero to two each and summing the five values. A score of 7 and above is considered normal, 4 to 6 low, and 3 or less critically low. The 1-minute score is used to assess how well the neonate tolerated the birthing process, and the 5-minute score is used to assess how well the neonate is adapting to the postnatal environment." ; rdfs:label "Low APGAR score" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0030918 dc:date "2016-11-07T18:06:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low one-minute APGAR score" ; a owl:Class ; rdfs:comment "A normal APGAR score can be coded as 'not Low 1-minute APGAR score'." ; rdfs:label "Low 1-minute APGAR score" ; rdfs:subClassOf obo:HP_0030917 . obo:HP_0030919 dc:date "2016-11-07T18:06:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low five-minute APGAR score" ; a owl:Class ; rdfs:comment "A normal APGAR score can be coded as 'not Low 5-minute APGAR score'." ; rdfs:label "Low 5-minute APGAR score" ; rdfs:subClassOf obo:HP_0030917 . obo:HP_0030920 dc:date "2016-11-07T18:14:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 0" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030921 dc:date "2016-11-07T18:14:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 1" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030922 dc:date "2016-11-07T18:14:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 2" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030923 dc:date "2016-11-07T18:14:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 3" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030924 dc:date "2016-11-07T18:14:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 4" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030925 dc:date "2016-11-07T18:14:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 5" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030926 dc:date "2016-11-07T18:15:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "5-minute APGAR score of 6" ; rdfs:subClassOf obo:HP_0030919 . obo:HP_0030927 dc:date "2016-11-07T18:16:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 0" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030928 dc:date "2016-11-07T18:16:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 1" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030929 dc:date "2016-11-07T18:16:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 2" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030930 dc:date "2016-11-07T18:16:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 3" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030931 dc:date "2016-11-07T18:16:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 4" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030932 dc:date "2016-11-07T18:16:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 5" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030933 dc:date "2016-11-07T18:16:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "1-minute APGAR score of 6" ; rdfs:subClassOf obo:HP_0030918 . obo:HP_0030934 obo:IAO_0000115 "A velvety red but not ulcerated lesion of the oral mucosa. The texture may be roughened or normal, and the lesion is neither raised nor depressed." ; dc:date "2016-11-07T18:48:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Oral erythroplasia" ; a owl:Class ; rdfs:comment "Oral erythroplakia may be related to local irritants and infection, candida infection. Oral erythroplakia may be dysplastic or (pre-)neoplastic." ; rdfs:label "Oral erythroplakia" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0030935 obo:IAO_0000115 "A structural anomaly of the nonstriated, involuntary muscle tissue of the intestine." ; dc:date "2016-12-02T15:17:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of intestinal smooth muscle morphology" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_2005273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030936 obo:IAO_0000115 "Abnormal layering of the intestinal muscularis propria into three layers; (1) inner circular; (2) additional oblique; and (3) outer longitudinal layer." ; dc:date "2016-12-02T15:21:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscularis propria malformation", "Segmental additional circular muscle coat" ; a owl:Class ; rdfs:comment "The intestinal muscularis propria is organized into discrete inner circular and outer longitudinal layers of muscle fibers that are oriented perpendicular to one another, except in the appendix, where the arrangement is more haphazard. The myenteric plexus of ganglia and nerves is sandwiched between the 2 muscle layers and is required for peristaltic activity. Maldevelopment or disruption of the neural or muscular elements can impair intestinal motility and cause intestinal pseudo-obstruction. This term refers to a malformation of the muscularis propria, with supernumerary and/or haphazard orientation of muscle fibers." ; rdfs:label "Abnormal layering of muscularis propria" ; rdfs:subClassOf obo:HP_0030935 . obo:HP_0030937 obo:IAO_0000115 "The presence of excessive fibrous connective tissue in the muscularis propria of the intestine. Fibrosis is a reparative or reactive process." ; dc:date "2016-12-02T21:21:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrotic muscularis propria" ; rdfs:subClassOf obo:HP_0030935 . obo:HP_0030938 obo:IAO_0000115 "Aggregates of stainable substances (proteins) in the nuclei of enteric neurons." ; dc:date "2016-12-05T13:25:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Enteric intraneuronal nuclear inclusion bodies" ; rdfs:subClassOf obo:HP_0025029 . obo:HP_0030939 obo:IAO_0000115 "An increased thickness of the eyelid not related to acute inflammation." ; dc:date "2016-12-05T13:46:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eyelid thickening", "Thick eyelids", "Thickened but nonswollen eyelids", "Thickened eyelid" ; a owl:Class ; rdfs:label "Palpebral thickening" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0030943 obo:IAO_0000115 "Pain in the vulvar area" ; dc:date "2016-12-14T13:34:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vulvar pain" ; a owl:Class ; rdfs:label "Vulvodynia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0030946 obo:IAO_0000115 "Raised tissue masses located on the palpebral conjunctiva with a central vessel. Papillae are created by a focal infiltration of inflammatory cells." ; dc:date "2017-01-13T20:21:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bumps under the upper eyelid", "Tarsal papillae" ; a owl:Class ; rdfs:comment "Papillae may be observed with papillary conjunctivitis. The inflammatory cells in the papillae may differ according to the cause. For instance, eosinophils predominate in allergic conditions and neutrophils in bacterial disease." ; rdfs:label "Conjunctival papillae" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0030947 obo:IAO_0000115 "Small, dome-shaped nodules without a prominent central vessel located on the conjunctiva. The lymphoid follicles are located in the subendothelial region of the conjunctiva. They consist of a germinal center that contains immature, proliferating lymphocytes, as well as a corona that contains mature lymphocytes and plasma cells." ; dc:date "2017-01-13T20:23:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The follicles in follicular conjunctivitis are usually most prominent in the inferior palpebral and forniceal conjunctiva. As compared to conjunctival papillae, conjunctival follicles appear more pale on the surface and redder at the base." ; rdfs:label "Conjunctival follicles" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0030948 obo:IAO_0000115 "Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues." ; dc:date "2017-01-13T21:20:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated serum GGT" ; a owl:Class ; rdfs:comment "Gamma-glutamyl transferase (GGT) is elevated with most liver diseases and with bile duct damage. Its main clinical use is in the evaluation of patients with isolated elevation in alkaline phosphatase (which can be of hepatic or bone origin). However, there are extrahepatic causes of GGT elevation including pancreatitis, prostate carcinoma, breast carcinoma, lung carcinoma, systemic lupus erythematosus, and congestive heart failure." ; rdfs:label "Elevated gamma-glutamyltransferase level" ; rdfs:subClassOf obo:HP_0034444 . obo:HP_0030949 obo:IAO_0000115 "An abnormal accumulation of protein in the glomerulus." ; dc:date "2017-01-13T21:44:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular deposits" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0030950 obo:IAO_0000115 "An abnormal increase in pressure in the pulmonary veins, usually as a result of left atrial hypertension." ; dc:date "2017-01-13T21:56:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Common causes of pulmonary venous hypertension are obstruction to left ventricular (LV) inflow, LV systolic dysfunction, severe mitral regurgitation, and acute pulmonary and systemic volume overload. As the pulmonary venous pressure nears 22 mm Hg, interstitial pulmonmary edema may develop. As it reaches 25 mm Hg, alveolar edema may ensue." ; rdfs:label "Pulmonary venous hypertension" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0030951 obo:IAO_0000115 "Excessive formation of fibrous bands of scar tissue in between muscle fibers." ; dc:date "2017-01-13T22:27:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: fibrosis" ; a owl:Class ; rdfs:comment "Pathophysiologic fibrosis, which is essentially an excessive accumulation of extracellular matrix components, particularly collagen, is the end result of a cascade of events proceeding from tissue injury via inflammation, and resulting in permanent scar formation. Fibrosis can impair tissue function. In skeletal muscle, fibrosis is most often associated with the muscular dystrophies." ; rdfs:label "Skeletal muscle fibrosis" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0030952 obo:IAO_0000115 "Multiple cream-yellow colored hypopigmented lesions typically located at the level of the choroid or retinal pigment epithelium; ovoid, cream-colored with indistinct borders. They are between 50 and 1,500 micrometers in size with a characteristic nasal, radial distribution in the postequatorial fundus." ; dc:date "2017-01-13T22:33:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Birdshot choroidal lesions", "Birdshot laesions", "Birdshot lesions" ; a owl:Class ; rdfs:label "Birdshot retinochoroidopathy" ; rdfs:subClassOf obo:HP_0000610 . obo:HP_0030953 obo:IAO_0000115 "Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera." ; dc:date "2017-01-13T22:41:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Conjunctival hyperaemia", "Conjunctival injection", "Conjunctival vascular congestion" ; a owl:Class ; rdfs:label "Conjunctival hyperemia" ; rdfs:subClassOf obo:HP_0000502, obo:HP_0025337 . obo:HP_0030955 obo:IAO_0000115 "An addictive behavior defined as drinking excessive amounts of alcohol over a long period of time, having difficulty reducing the amount of alcohol consumed, strongly desiring alcohol and experiencing withdrawal symptoms when not drinking alcohol." ; dc:date "2017-01-13T22:59:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alcoholism" ; rdfs:subClassOf obo:HP_0030858 . obo:HP_0030956 obo:IAO_0000115 "An anomaly of the electrical conduction physiology of the heart." ; dc:date "2017-03-17T17:47:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of cardiovascular system electrophysiology" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0030957 obo:IAO_0000115 "A bowing (bulging to one side) of the interventricular septum of more than 15 mm on either side in adults and 5 mm in children during normal cardiac motion." ; dc:date "2017-03-17T20:01:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasNarrowSynonym "Ventricular septal dilatation" ; a owl:Class ; rdfs:comment "Interventricular septal aneuryms may involve either the membranous or muscular portion of the interventricular septum. Membranous interventricular septal aneurysm is more common." ; rdfs:label "Ventricular septal aneurysm" ; rdfs:subClassOf obo:HP_0010438 . obo:HP_0030958 obo:IAO_0000115 "Bowing (bulging out) of the membranous part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle)." ; dc:date "2017-03-17T20:04:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2346" ; oboInOwl:hasExactSynonym "Interventricular septum membranous part aneurysm" ; oboInOwl:hasNarrowSynonym "Aneurysm of the membranous ventricular septum" ; a owl:Class ; rdfs:comment "The pars membranacea is the last portion of the septum formed in the fetus, is lo-cated between the left and right ventricles in front of the tricuspid valve, and between the left ventricle and the right atrium, behind the tricuspid valve. It lies in close proximity to the aortic and atrioventricular valves and is considered to be the weakest part of the ventricular septum. The aneurysms of the membranous portion usually measure 1 to 2 cm in all diameters and their walls are composed of fibrous tissue forming thick trabeculae when seen from the left ventricle. They can project into different portions of the right ventricle or right atrium." ; rdfs:label "Membranous ventricular septal aneurysm" ; rdfs:subClassOf obo:HP_0030957 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004666 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030959 obo:IAO_0000115 "Bowing (bulging out) of the muscular part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle)." ; dc:date "2017-03-17T20:22:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aneurysm of the muscular ventricular septum" ; a owl:Class ; rdfs:comment "Aneurysm of the muscular interventricular septum is a rare entity compared to aneurysms of the membranous part. The majority of cases are due to a previous history of myocardial infarction or VSD closure. Muscular interventricular septal aneurysm can arise from the basal, mid or apical part." ; rdfs:label "Muscular ventricular septal aneurysm" ; rdfs:subClassOf obo:HP_0030957 . obo:HP_0030960 obo:IAO_0100001 "HP:0000615" ; a owl:Class ; rdfs:label "obsolete Abnormal pupillary morphology" ; owl:deprecated true . obo:HP_0030961 obo:IAO_0000115 "Lens of the eye is smaller than normal and spherically shaped." ; dc:date "2017-04-18T12:55:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Microspherophakia" ; rdfs:subClassOf obo:HP_0008063, obo:HP_0034375 . obo:HP_0030962 obo:IAO_0000115 "A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta." ; dc:date "2017-04-18T13:00:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of the great vessels" ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013768 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030963 obo:IAO_0100001 "HP:0001679" ; a owl:Class ; rdfs:label "obsolete Abnormal aortic morphology" ; owl:deprecated true . obo:HP_0030964 dc:date "2017-04-18T13:14:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal aortic physiology" ; rdfs:subClassOf obo:HP_0025323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000947 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030965 obo:IAO_0000115 "The elastic properties of the aorta allow the aorta to store half of the cardiac ejected blood volume per beat, whereby aortic recoil during diastole pushes the remaining stored volume forward into the peripheral circulation, a phenomenon known as the Windkessel function. Aortic stiffness occurs as the elastic fibers within the arterial wall become disrupted due to mechanical stress (with age or due to other factors). Aortic stiffness refers to a reduction in the elasticity of the aorta, which is associated with an elevated pulse pressure, increased wave reflection, and often hypertension." ; dc:date "2017-04-18T13:16:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased aortic stiffness" ; a owl:Class ; rdfs:label "Aortic stiffness" ; rdfs:subClassOf obo:HP_0030964 . obo:HP_0030966 obo:IAO_0000115 "An abnormality of the structure of the pulmonary artery." ; dc:date "2017-04-18T13:29:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary artery morphology" ; rdfs:subClassOf obo:HP_0004414, obo:HP_0030962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030967 obo:IAO_0000115 "An abnormality of the function of the pulmonary artery." ; dc:date "2017-04-18T13:29:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary artery physiology" ; rdfs:subClassOf obo:HP_0004414 . obo:HP_0030968 obo:IAO_0000115 "An abnormality of the structure of the pulmonary veins." ; dc:date "2017-04-18T13:38:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:3000" ; a owl:Class ; rdfs:label "Abnormal pulmonary vein morphology" ; rdfs:subClassOf obo:HP_0011718, obo:HP_0030962 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030969 obo:IAO_0000115 "An abnormality of the function of the pulmonary veins." ; dc:date "2017-04-18T13:38:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary vein physiology" ; rdfs:subClassOf obo:HP_0011718 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030970 obo:IAO_0000115 "An abnormality of the function of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava." ; dc:date "2017-04-18T13:41:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vena cava physiology" ; rdfs:subClassOf obo:HP_0030846 . obo:HP_0030971 obo:IAO_0100001 "HP:0005345" ; a owl:Class ; rdfs:label "obsolete Abnormal vena cava morphology" ; owl:deprecated true . obo:HP_0030972 obo:IAO_0000115 "A chronic deviation from normal pressure in the systemic arterial system." ; dc:date "2017-04-18T13:55:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal systemic BP" ; a owl:Class ; rdfs:label "Abnormal systemic blood pressure" ; rdfs:subClassOf obo:HP_0011025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001025 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] . obo:HP_0030973 obo:IAO_0000115 "Post-exertional symptom exacerbation (PESE), also referred to as post-exertional malaise (PEM), is defined as the worsening of symptoms that can follow minimal cognitive, physical, emotional, or social activity, or activity that could previously be tolerated. Symptoms typically worsen 12 to 72 hours after activity and can last for days or even weeks, sometimes leading to a relapse." ; dc:date "2017-04-18T14:35:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Exercise-induced malaise", "Postexertional malaise" ; a owl:Class ; rdfs:comment "PEM can be observed in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), as a post-acute sequela of SARS-CoV-2 infection (long COVID), and occasionally in individuals with mitochondrial disorders or cancer related fatigue. It is often accompanied by exacerabtion or new onset of exhaustion, cognitive impairment, muscle pain, muscle weakness, or other manifestations. The onset of PEM may occur hours or even days after exertion, and recovery from PEM is often slow, taking place over days or weeks or longer. PESE can contribute to the episodic nature of disability in post COVID-19 condition, often presenting as unpredictable fluctuations in symptoms and function." ; rdfs:label "Postexertional symptom exacerbation" ; rdfs:subClassOf obo:HP_0003546 . obo:HP_0030974 obo:IAO_0000115 "A type of oligozoospermia in which spermatozoa can be detected in an ejaculate only after centrifugation and inspection of the pellet." ; dc:date "2017-04-18T15:25:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cryptospermia" ; a owl:Class ; rdfs:label "Cryptozoospermia" ; rdfs:subClassOf obo:HP_0000798 . obo:HP_0030975 obo:IAO_0000115 "An abnormal curved or vaulted (capped) structure covering the middle third of the dorsal pontine tegmentum and projecting into the fourth ventricle." ; dc:date "2017-04-28T14:09:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vaulted pontine tegmentum" ; a owl:Class ; rdfs:label "Pontine tegmental cap" ; rdfs:subClassOf obo:HP_0007361 . obo:HP_0030976 obo:IAO_0000115 "A deviation from the normal activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X." ; dc:date "2017-05-10T22:59:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal factor VIII activity" ; rdfs:subClassOf obo:HP_0010989 . obo:HP_0030977 obo:IAO_0000115 "Increased activity of the coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X." ; dc:date "2017-05-10T23:00:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated factor VIII level" ; a owl:Class ; rdfs:comment "Levels of Factor VIII above 250 IU/dL are associated with an increased risk of venous thrombosis." ; rdfs:label "Increased factor VIII activity" ; rdfs:subClassOf obo:HP_0030976 . obo:HP_0030978 obo:IAO_0000115 "A reduction below normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration." ; dc:date "2017-06-05T10:50:18Z" ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased CSF/serum albumin ratio" ; rdfs:subClassOf obo:HP_0030981 . obo:HP_0030979 obo:IAO_0000115 "Enlargement of the large blood vessels in the choroid." ; dc:date "2017-05-10T23:59:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dilated choroidal vessels" ; a owl:Class ; rdfs:comment "Choroidal thickening can be a feature of central serous chorioretinopathy and results from focal or diffuse dilatation of large choroidal vessels, which are commonly localized within areas of increased choroidal vascular permeability on indocyanine green angiography." ; rdfs:label "Dilatation of large choroidal vessels" ; rdfs:subClassOf obo:HP_0025568 . obo:HP_0030980 obo:IAO_0000115 "An decrease in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2017-05-05T09:56:23Z" ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced brain glutamine level by MRS" ; rdfs:subClassOf obo:HP_0034496 . obo:HP_0030981 obo:IAO_0000115 "A deviation from the normal range of the ratio of the albumin concentration in the cerebrospinal fluid (CSF) to the concentration in serum (which may be defined as 3.2-9.0). This is an index of blood-brain barrier (BBB) integrity, adjusted for the serum albumin concentration, and an increased ratio is taken as a sign of a loss of integrity of the BBB with leakage of albumin into the CSF." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal CSF/serum albumin ratio" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0030983 obo:IAO_0000115 "A sex cord-stromal tumor of the ovary. Thecomas range from small tumors to large solid or solid-cystic masses of up to 15 cm. They are unilateral in over 90 percent of cases and are rarely malignant. Thecomas are stromal tumors made up of cells that resemble theca cells, lutein cells and fibroblasts. They are traditionally classified within the sex cord-stromal tumor category of ovarian tumor types." ; dc:date "2017-05-31T00:22:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ovarian thecoma" ; rdfs:subClassOf obo:HP_0031918 . obo:HP_0030984 obo:IAO_0000115 "A deviation from the normal concentration of serum bile acid concentration." ; dc:date "2017-05-13T12:45:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are two major bile acids, cholic acid and chenodeoxycholic acid, which are synthesised in the hepatocyte by the cytochrome P450-mediated oxidation of cholesterol. These bile acids are secreted into the biliary canaliculi as sodium salts and conjugated with glycine, taurine, sulphate or glucuronic acid, and stored in the gall bladder until excreted into the intestinal lumen in response to a fatty meal. Enterohepatic circulation of bile salts is associated with conversion of the primary bile salts to seconday bile salts by bacerial enyzmes. The total bile pool of about 4 grams is recirculated about 5 to 10 times per day. Because serum bile salt concentration can increase by two to five times after a meal it is important that bile salts are measured while the subject is fasting." ; rdfs:label "Abnormal serum bile acid concentration" ; rdfs:subClassOf obo:HP_0010996 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030985 obo:IAO_0000115 "A reduction in the concentration of bile acid in the blood." ; dc:date "2017-05-13T13:02:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased serum bile acid concentration" ; rdfs:subClassOf obo:HP_0030984 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_3098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0030986 obo:IAO_0000115 "Hyperplasia of lining epithelia of the septal and large bile ducts manifesting as micropapillary projections or as a stratification of the epithelium with or without dilatation of the duct lumen." ; dc:date "2017-05-13T13:29:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Biliary epithelial hyperplasia" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0030987 obo:IAO_0000115 "Cholangitis characterized by the presence of numerous polymorphonuclear cells around and within the wall as well as within the lumen of the ducts. This may involve ducts of any size and is occasionally associated with abscess formation (cholangitic abscess)." ; dc:date "2017-05-13T13:33:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A microbial infection is often for suppurative cholangitis, but the change also occurs in the presence of sterile bile, particularly after bile extravasation. The release of chemokines or cytokines is the likely cause in some cases." ; rdfs:label "Suppurative cholangitis" ; rdfs:subClassOf obo:HP_0030151 . obo:HP_0030988 obo:IAO_0000115 "Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts." ; dc:date "2017-05-13T13:35:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Granulomatous cholangitis involving the interlobular bile ducts constitutes the hallmark of primary biliary cholangitis and is also found in drug-induced liver disease and sarcoidosis." ; rdfs:label "Granulomatous cholangitis" ; rdfs:subClassOf obo:HP_0030151 . obo:HP_0030989 obo:IAO_0000115 "Cholangitis characterized by a close association between duct branches, usually interlobular bile ducts, and lymphocytic aggregates, which may show a follicular arrangement." ; dc:date "2017-05-13T13:40:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lymphoid cholangitis" ; rdfs:subClassOf obo:HP_0030151 . obo:HP_0030990 obo:IAO_0000115 "Cholangitis associated with mixed inflammatory infiltrates and the presence of fibrosis or sclerosis of the biliary tree." ; dc:date "2017-05-13T13:41:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleomorphic cholangitis" ; rdfs:subClassOf obo:HP_0030151 . obo:HP_0030991 obo:IAO_0000115 "Cholangitis associated with evident ductal fibrosis that develops as a consequence of long-standing bile duct inflammatory, obstruction, or ischemic injury; it can be obliterative or nonobliterative." ; dc:date "2017-05-13T13:42:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fibrous cholangitis" ; a owl:Class ; rdfs:label "Sclerosing cholangitis" ; rdfs:subClassOf obo:HP_0030151 . obo:HP_0030992 obo:IAO_0000115 "Any structural anomaly of the pancreatic duct, which is the tubular structure that collects exocrine pancreatic secretions and transports them to the duodenum." ; dc:date "2017-05-13T13:51:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The pancreas develops from dorsal and ventral buds that first appear in the fifth gestational week as outgrowths of the primitive foregut. By the seventh gestational week, expansion of the duodenum causes the ventral bud to rotate and pass behind the duodenum from right to left and fuse with the dorsal bud. The ventral bud forms the posterior head and uncinate process, whereas the dorsal bud forms the anterior head, body, and tail. Following this fusion, the ductal systems anastomose, a complicated process with a wide spectrum of possible outcomes. The portion of the ventral duct between the dorsal-ventral fusion and major papilla is termed the duct of Wirsung. The portion of the dorsal duct upstream to the dorsalventral fusion point is called the main pancreatic duct. The segment of the dorsal duct downstream to the dorsal-ventral fusion point is termed the duct of Santorini, or accessory pancreatic duct, which drains at the papilla minor [PMID:242655659]." ; rdfs:label "Abnormal pancreatic duct morphology" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0030993 obo:IAO_0000115 "A congenital anomaly characterized by the presence of two separate pancreatic ducts." ; dc:date "2017-05-13T13:55:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Duplicated pancreatic duct" ; a owl:Class ; rdfs:label "Duplication of pancreatic duct" ; rdfs:subClassOf obo:HP_0030992 . obo:HP_0030994 obo:IAO_0000115 "A congenital anomaly of the pancreas that results from failed fusion of the dorsal and ventral ducts during embyological development. Three variants have been described: type 1 or classical divisum in which there is total failure of fusion; type 2 in which dorsal drainage is dominant in the absence of the duct of Wirsung; and type 3 or incomplete divisum where a small communicating branch is present." ; dc:date "2017-05-13T13:56:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In pancreas divisum, the majority of the pancreatic gland drains into the minor papilla via the duct of Santorini, whereas the posterior head and uncinate process drain into the major papilla via the duct of Wirsung with the common bile duct. Although most patients are asymptomatic, in some patients, this anomaly is associated with recurrent acute pancreatitis because of inadequate drainage of pancreatic secretions via the minor papilla." ; rdfs:label "Pancreas divisum" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0030995 obo:IAO_0000115 "An increase in the amount of fluid present in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen)." ; dc:date "2017-05-13T14:07:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peritoneal effusion" ; rdfs:subClassOf obo:HP_0002585 . obo:HP_0030996 obo:IAO_0000115 "Dilation and elongation of the duodenum with hypertrophy of all layers of the duodenum." ; dc:date "2017-05-13T14:10:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Megaduodenum may present with a feeling of gastric fullness, epigastric pain, belching, heartburn, and nausea with vomiting." ; rdfs:label "Megaduodenum" ; rdfs:subClassOf obo:HP_0002246 . obo:HP_0030997 obo:IAO_0000115 "Abnormal closure or blockage of the vas deferens." ; dc:date "2017-05-13T14:13:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atresia of the vas deferens", "Vas deferens atresia" ; a owl:Class ; rdfs:label "Atretic vas deferens" ; rdfs:subClassOf obo:HP_0012872 . obo:HP_0030998 obo:IAO_0000115 "Drainage of cerebrospinal fluid through the nose. This can occur when there is a fistula between the dura and the skull base and discharge of cerebrospinal fluid (CSF) from the nose." ; dc:date "2017-05-13T18:30:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CSF rhinorrhoea" ; a owl:Class ; rdfs:comment "CSF rhinorrhea or liquorrhoea commonly occurs following head trauma (fronto-basal skull fractures), as a result of intracranial surgery, or destruction lesions. A spinal fluid leak from the intracranial space to the nasal respiratory tract is potentially very serious because of the risk of an ascending infection which could produce fulminant meningitis." ; rdfs:label "Cerebrospinal fluid rhinorrhoea" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0030999 obo:IAO_0000115 "Any structural anomaly of the saccule of the vestibule. The saccule is the otolith organ that senses motions in the sagittal plane (i.e., up-down movement)." ; dc:date "2017-05-13T18:38:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vestibular saccule morphology" ; rdfs:subClassOf obo:HP_0011376 . obo:HP_0031000 obo:IAO_0000115 "Deterioration or loss of the tissues of the saccule of the vestibule." ; dc:date "2017-05-13T20:01:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vestibular saccular degeneration" ; rdfs:subClassOf obo:HP_0030999 . obo:HP_0031001 obo:IAO_0000115 "A nerve fascicle or fasciculus is a small bundle of axons, enclosed by the perineurium. A minifascule refers to a group of thinly myelinated and unmyelinated axons surrounded by a delicate perineurium, and with a smaller diameter than a normal nerve fascicle." ; dc:date "2017-05-13T20:08:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Minifascicle formation" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0031002 obo:IAO_0000115 "Inflammation of a nerve." ; dc:date "2017-05-13T20:14:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neuritis" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0031003 obo:IAO_0000115 "Simulataneous inflammation of multiple nerves." ; dc:date "2017-05-13T20:14:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multiple neuritis" ; a owl:Class ; rdfs:label "Polyneuritis" ; rdfs:subClassOf obo:HP_0031002 . obo:HP_0031004 obo:IAO_0000115 "Areflexia that is limited to one side of the body." ; dc:date "2017-05-13T20:18:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hemiareflexia" ; rdfs:subClassOf obo:HP_0001284 . obo:HP_0031005 obo:IAO_0100001 "HP:0012534" ; dc:date "2017-05-13T20:21:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Hyperalgesia" ; owl:deprecated true . obo:HP_0031006 obo:IAO_0000115 "A type of paresthesia (tingling, pins-and-needles, burning or numbness or stiffness) that occurs in the hands and feet and particularly in the fingers and toes." ; dc:date "2017-05-13T20:23:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acroparesthesia" ; rdfs:subClassOf obo:HP_0003401 . obo:HP_0031007 dc:date "2017-05-13T21:07:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Jaw dystonia induced by speaking" ; a owl:Class ; rdfs:label "Orofacial action-specific dystonia induced by speech" ; rdfs:subClassOf obo:HP_0012179 . obo:HP_0031008 obo:IAO_0000115 "Involuntary protrusions, movements, spams and contortions of the tongue." ; dc:date "2017-05-13T21:10:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tongue dystonia" ; a owl:Class ; rdfs:comment "Tongue dystonia may be triggered by speaking but not during other tasks such as eating, drinking, whistling, and blowing." ; rdfs:label "Lingual dystonia" ; rdfs:subClassOf obo:HP_0012179 . obo:HP_0031009 obo:IAO_0000115 "Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation." ; dc:date "2017-05-13T21:33:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dactylolysis spontanea" ; a owl:Class ; rdfs:label "Ainhum" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0031010 obo:IAO_0000115 "An accessory phalanx of the third (middle) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint." ; dc:date "2017-05-13T21:44:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperphalangy of third finger" ; a owl:Class ; rdfs:label "Hyperphalangy of the 3rd finger" ; rdfs:subClassOf obo:HP_0030367 . obo:HP_0031011 obo:IAO_0000115 "Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV." ; dc:date "2017-05-18T02:35:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Sudanophilic lesion" ; a owl:Class ; rdfs:comment "Some early studies used the terms sudanophilic lesion or sudanophilia to refer to fatty streaks." ; rdfs:label "Fatty streak" ; rdfs:subClassOf obo:HP_0002621 . obo:HP_0031012 obo:IAO_0000115 "Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring less than 65 micrometers and typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis." ; dc:date "2017-05-18T02:45:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "TCFA" ; a owl:Class ; rdfs:label "Thin-cap fibroatheroma" ; rdfs:subClassOf obo:HP_0002621 . obo:HP_0031013 obo:IAO_0000115 "A reduction of joint mobility resulting from changes involving the articular surfaces." ; dc:date "2017-05-18T02:58:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Note that contracture refers to a reduction of joint mobility due to permanent shortening of the soft parts around a joint, muscles, tendons, ligaments, fasciae, or skin. Ankylosis and contracture can occur together or alone. Fibrous ankylosis refers to adhesions between the opposing surface of a joint. Cartilaginous ankylosis implies the fusion of two apposed cartilaginous surfaces. Bony ankylosis or synostosis refers to an osseous union between articulating surfaces." ; rdfs:label "Ankylosis" ; rdfs:subClassOf obo:HP_0001376 . obo:HP_0031014 obo:IAO_0000115 "Usually, three large arteries arise from the arch of the aorta: the brachiocephalic trunk (divided into the right common carotid artery and the right subclavian artery), the left common carotid artery, and the left subclavian artery. However, when aberrant right subclavian artery variant is present, the brachiocephalic trunk is absent and four large arteries arise from the arch of the aorta: the right common carotid artery, the left common carotid artery, the left subclavian artery, and the final one with the most distal left sided origin, the right subclavian artery, also called the arteria lusoria." ; dc:date "2017-05-18T03:40:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aberrant right subclavian artery", "Lusorian artery" ; a owl:Class ; rdfs:label "Arteria lusoria" ; rdfs:subClassOf obo:HP_0031251 . obo:HP_0031015 obo:IAO_0000115 "Sclerosis of the intrahepatic portal veins of the liver and generally accompanied by non-cirrhotic portal hypertension, features of which may include splenomegaly and varices." ; dc:date "2017-05-20T11:15:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Idiopathic non-cirrhotic portal hypertension", "Incomplete septal cirrhosis", "Non cirrhotic portal fibrosis", "Obliterative portal venopathy" ; a owl:Class ; rdfs:comment "The diagnosis is based on histological examination of the liver. Clinical manifestations include encephalopathy, ascites and variceal bleeding." ; rdfs:label "Intrahepatic portal vein sclerosis" ; rdfs:subClassOf obo:HP_0031941 . obo:HP_0031016 obo:IAO_0000115 "Areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra." ; dc:date "2017-05-20T11:32:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Zebra stripe sign" ; a owl:Class ; rdfs:comment "In cases where this sign arises in children treated with bisphosphonates, the sign is known as the zebra stripe sign, which is radiological manifestation of cyclical bisphosphonate therapy prior to closure of epiphyseal growth plates." ; rdfs:label "Alternating radiolucent and radiodense metaphyseal lines" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0031017 obo:IAO_0000115 "Multiple defects in the atrial septum." ; dc:date "2017-05-20T11:43:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The label derives from the resemblance of the multiple atrial defects to Emmental cheese, a medium-hard cheese of Swiss origin that features characteristic holes." ; rdfs:label "Swiss cheese atrial septal defect" ; rdfs:subClassOf obo:HP_0001631 . obo:HP_0031018 obo:IAO_0000115 "Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA)." ; dc:date "2017-05-31T00:32:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acrosyringeal adenomatosis", "Eccrine syringofibroadenomatous hyperplasia", "Syringofibroadenoma" ; a owl:Class ; rdfs:label "Eccrine syringofibroadenoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0031019 obo:IAO_0000115 "Nuclear lobes of neutrophils in the bone marrow are thickened and condensed, and individual lobes are connected by unusually long chromatin filaments." ; dc:date "2017-06-14T16:30:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pyknotic bone marrow neutrophils" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0031020 obo:IAO_0000115 "A larger than normal amount or percentage of hematopoietic cells relative to marrow fat." ; dc:date "2017-06-14T16:35:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myeloid hyperplasia" ; a owl:Class ; rdfs:label "Bone marrow hypercellularity" ; rdfs:subClassOf obo:HP_0012145 . obo:HP_0031021 obo:IAO_0000115 "A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy [NCI thesaurus]." ; dc:date "2017-05-21T13:13:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3712" ; a owl:Class ; rdfs:label "Squamous Papilloma" ; rdfs:subClassOf obo:HP_0012740 . obo:HP_0031022 obo:IAO_0000115 "A benign exophytic neoplasm that arises from the oropharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium [NCI thesaurus]." ; dc:date "2017-05-21T13:15:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C6038" ; oboInOwl:hasNarrowSynonym "Squamous papilloma of the uvula" ; a owl:Class ; rdfs:label "Oropharyngeal squamous papilloma" ; rdfs:subClassOf obo:HP_0031021 . obo:HP_0031023 obo:IAO_0000115 "Multiple painful, dome-shaped, translucent pink to skin-colored papules on oral mucosa. Histologically, the lesions may demonstrate dermal proliferation of well-demarcated nerve bundles associated with abundant mucin and surrounded by a distinct perineural sheath." ; dcterms:creator ; oboInOwl:creation_date "2017-05-21T13:18:01Z"^^xsd:dateTime ; oboInOwl:hasDbXref "NCIT:C6559" ; a owl:Class ; rdfs:label "Multiple mucosal neuromas" ; rdfs:subClassOf obo:HP_0030430 . obo:HP_0031024 obo:IAO_0000115 "A benign skin adnexal tumor of eccrine differentiation." ; dc:date "2017-05-21T13:32:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cylindromas can be single or multiple and commonly involve the scalp (turban tumor) and face. Multiple cylindromas can have a syndromic association as seen in Brooke-Spiegler syndrome and familial cylindromatosis." ; rdfs:label "Cylindroma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0031025 obo:IAO_0000115 "A malignant neoplasm of the stomach that grows submucosally in the gastric wall. Necrosis and hemorrhage may be visible radiologically. Histologically, spindle cells with abnormal mitotic activity may be visible." ; dc:date "2017-05-21T13:42:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Gastric leiomyosarcomas are often clinically silent until they reach a large size, bleed or rupture. Thus, the diagnosis is rarely made preoperatively. Since in many cases the mucosa is normal, a definitive diagnosis for resectable tumor is often made after surgery. Seeding of tumor deposits into the serosa or omentum is almost invariably a sign of malignancy." ; rdfs:label "Gastric leiomyosarcoma" ; rdfs:subClassOf obo:HP_0006753 . obo:HP_0031026 obo:IAO_0000115 "The ilia is round and hypoplastic with a very flat acetabular roof and a very unusual medial projection of bone that is said to resemble the head of a snail. Figure 4 of PMID:3799723 illustrates this feature." ; dc:date "2017-05-21T15:50:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Snail-like pelvis", "Snail-shaped ilia" ; oboInOwl:hasRelatedSynonym "Schneckenbecken dysplasia" ; a owl:Class ; rdfs:comment "This feature was first observed in a condition that was termed Schneckenbecken dysplasia, Schneckenbecken is a German word that means snail-like pelvis." ; rdfs:label "Snail-like ilia" ; rdfs:subClassOf obo:HP_0002867 . obo:HP_0031027 obo:IAO_0000115 "A small V-shaped indentation on the internal aspect of the femoral head. This feature is well illustrated in Figure 5 of PMID:11694546." ; dc:date "2017-05-21T16:09:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Internal notch of the femoral head" ; rdfs:subClassOf obo:HP_0003368 . obo:HP_0031028 obo:IAO_0000115 "Serum sample with a grossly white (milk-like, i.e., lactescent) appearance. This feature is indicative of an extremely elevated serum triglyceride level." ; dc:date "2017-05-27T10:37:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Milk-like serum", "Plasma lactescence" ; a owl:Class ; rdfs:comment "The normal range for serum triglycerides can be taken to be 40 to 150 mg per dL (0.45 to 1.69 mmol per L). Lactescent serum can be seen with triglyceride levels of several thousand mg per dL." ; rdfs:label "Lactescent serum" ; rdfs:subClassOf obo:HP_0002155 . obo:HP_0031029 obo:IAO_0000115 "An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker." ; dc:date "2017-05-27T10:48:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased plasma CEA" ; a owl:Class ; rdfs:label "Elevated carcinoembryonic antigen level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031030 obo:IAO_0000115 "An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer." ; dc:date "2017-05-27T10:54:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased plasma CA125" ; a owl:Class ; rdfs:label "Elevated carcinoma antigen 125 level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031031 obo:IAO_0000115 "A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol." ; dc:date "2017-05-27T10:59:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal retinol-binding protein level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031032 obo:IAO_0000115 "A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity." ; dc:date "2017-05-27T11:03:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased retinol-binding protein level" ; rdfs:subClassOf obo:HP_0031031 . obo:HP_0031033 obo:IAO_0000115 "The kidney contributes towards acid-base homeostasis by excreting H+ ions and retaining bicarbonate. This process is known as acidification of the urine. The pH of urine ranges normally from 4.5 to 8. The inability to reduce the pH of the urine in a situation where it would be otherwise expected is known as an acidification defect." ; dc:date "2017-05-27T11:07:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal acidification defect" ; a owl:Class ; rdfs:label "Impaired urinary acidification" ; rdfs:subClassOf obo:HP_0012211 . obo:HP_0031034 obo:IAO_0000115 "A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier." ; dc:date "2017-05-27T11:20:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Plasma IGFALS is positively associated with prostate cancer risk." ; rdfs:label "Abnormal insulin like growth factor binding protein acid labile subunit level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031035 obo:IAO_0000115 "Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection." ; dc:date "2017-06-14T16:40:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Chronic infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0031036 obo:IAO_0000115 "A decreased blood concentration of growth hormone binding protein." ; dc:date "2017-05-27T11:34:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased plasma GH-binding protein" ; a owl:Class ; rdfs:label "Reduced growth-hormone binding protein level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031037 obo:IAO_0000115 "Blood concentration of insulin-like factor 3 (ILF3) is below normal limits." ; dc:date "2017-05-27T11:44:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced plasma INSL3 level" ; a owl:Class ; rdfs:comment "Insulin-like factor 3 (INSL3) is a peptide hormone produced in leydig cells of the testes. Its role in the adult male is unknown but INSL3 and its receptor RXFP2 have been linked to bone cell differentiation. It is speculated that low levels of INSL3 could be responsible for low bone mineral density in patients with primary osteoporosis and Klinefelter Syndrome." ; rdfs:label "Reduced insulin-like factor 3 level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031038 obo:IAO_0000115 "Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa." ; dc:date "2017-05-27T11:49:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Meiotic maturation arrest of spermatogenesis" ; a owl:Class ; rdfs:comment "Maturation arrest (MA) of spermatogenesis is diagnosed on histology as interruption of spermatogenesis before the final stage without impairment of Sertoli or Leydig cells. It is considered a condition of irreversible or absolute infertility." ; rdfs:label "Spermatogenesis maturation arrest" ; rdfs:subClassOf obo:HP_0008669 . obo:HP_0031039 obo:IAO_0000115 "A type of maturation arrest in which only spermatogonia or spermatocytes are found." ; dc:date "2017-05-27T11:50:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spermatocytic arrest" ; a owl:Class ; rdfs:label "Early spermatogenesis maturation arrest" ; rdfs:subClassOf obo:HP_0031038 . obo:HP_0031040 obo:IAO_0000115 "A failure of spermatogenesis to progress beyond the round spermatid stage. The round spermatid is the first haploid cells produced during spermatogenesis and normally further develop into mature spermatozoa. This abnormality can be visualized with testicular biopsy and is characterized seminiferous tubules with increased numbers of round spermatids with few or no mature spermatozoa." ; dc:date "2017-05-27T11:51:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maturation arrest of spermatogenesis at spermatid stage" ; oboInOwl:hasRelatedSynonym "Late spermatogenesis maturation arrest" ; a owl:Class ; rdfs:comment "See Figure 2c and 2d of PMID:9510006." ; rdfs:label "Round spermatid arrest" ; rdfs:subClassOf obo:HP_0031038 . obo:HP_0031041 obo:IAO_0000115 "Blockage of blood flow through the superior vena cava (SVC). Because the venous drainage from the upper extremities, upper thorax and head is obstructed, SVC obstruction presents with symptoms related to engorgement of these areas. Both the degree of SVC compromise and the extent of collateral veins determine the varied clinical presentation, which can be as mild as slight facial and upper extremity edema or as dire as intracranial swelling, seizures, hemodynamic instability and tracheal obstruction." ; dc:date "2017-05-27T12:23:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Superior vena cava obstruction" ; oboInOwl:hasRelatedSynonym "Superior vena cava syndrome" ; a owl:Class ; rdfs:comment "Diagnosis of superior vena cava obstruction may be made by computed tomography with contrast and other means." ; rdfs:label "Obstruction of the superior vena cava" ; rdfs:subClassOf obo:HP_0025575 . obo:HP_0031042 obo:IAO_0000115 "Inflammed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry." ; dc:date "2017-05-27T13:34:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Raspberry tongue" ; a owl:Class ; rdfs:label "Strawberry tongue" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0031043 obo:IAO_0000115 "A type of brachydactyly characterized by brachymesophalangy affecting mainly the 2nd and 5th digits." ; dc:date "2017-05-27T13:45:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Type A4 brachydactyly" ; rdfs:subClassOf obo:HP_0009370 . obo:HP_0031044 obo:IAO_0000115 "A type of brachydactyly characterized by absent middle phalanges of digits 2 to 5." ; dc:date "2017-05-27T13:48:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Individuals with BDA5 may have nail dysplasia; this should be coded separately." ; rdfs:label "Type A5 brachydactyly" ; rdfs:subClassOf obo:HP_0009370 . obo:HP_0031045 obo:IAO_0000115 "Bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet)." ; dc:date "2017-05-27T14:02:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acral blistering" ; rdfs:subClassOf obo:HP_0033800 . obo:HP_0031046 obo:IAO_0000115 "A developmental defect characterized by lack of a soft palate." ; dc:date "2017-05-27T14:06:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Agenesis of the soft palate" ; a owl:Class ; rdfs:label "Absent soft palate" ; rdfs:subClassOf obo:HP_0100736 . obo:HP_0031047 obo:IAO_0000115 "An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells." ; dc:date "2017-05-27T14:25:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Monoclonal hypergammaglobulinemia" ; a owl:Class ; rdfs:comment "A paraprotein is a monoclonal immunoglobulin or light chain present in the blood or urine; it is produced by a clonal population of mature B cells, most commonly plasma cells. Plasma cell disorders can be considered as a spectrum of conditions ranging from monoclonal gammopathy of undetermined significance (MGUS), through asymptomatic, to symptomatic myeloma. The frequency of paraprotein-associated heavy chains is IgG, IgA, IgM, IgD (in that order). Light chains may be kappa or lambda. Paraproteins are associated with both malignant and nonmalignant conditions and may lead to complications including neuropathy and nephropathy." ; rdfs:label "Paraproteinemia" ; rdfs:subClassOf obo:HP_0010702 . obo:HP_0031048 obo:IAO_0000115 "An abnormal immunoglobulin light chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dc:date "2017-05-27T14:28:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Light-chain paraproteinemia" ; rdfs:subClassOf obo:HP_0031047 . obo:HP_0031049 obo:IAO_0000115 "An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dc:date "2017-05-27T14:29:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD)." ; rdfs:label "Heavy-chain paraproteinemia" ; rdfs:subClassOf obo:HP_0031047 . obo:HP_0031050 obo:IAO_0000115 "An abnormal immunoglobulin (heavy and light chain) in the circulation and typically produced by a clonal population of B-cell derived plasma cells." ; dc:date "2017-05-27T14:30:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Whole-immunoglobulin paraproteinemia" ; rdfs:subClassOf obo:HP_0031047 . obo:HP_0031051 obo:IAO_0000115 "An elevation in bone density in one or more tarsal bones of the foot. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; dc:date "2017-05-27T14:41:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tarsal sclerosis" ; rdfs:subClassOf obo:HP_0009132, obo:HP_0100925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031052 obo:IAO_0000115 "Increased blood concentration of vascular endothelial growth factor (VEGF)." ; dc:date "2017-05-27T15:09:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating VEGF concentration" ; a owl:Class ; rdfs:label "Elevated vascular endothelial growth factor level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0031053 obo:IAO_0000115 "Narrowing or constriction of the aorta localized to the region of the transverse aortic arch." ; dc:date "2017-05-27T17:07:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coarctation in the transverse aortic arch" ; rdfs:subClassOf obo:HP_0001680 . obo:HP_0031054 obo:IAO_0000115 "Coarctation of the aorta is a narrowing or constriction of a long segment of the arch of the aorta." ; dc:date "2017-05-27T17:10:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Long segment coarctation of the aorta" ; rdfs:subClassOf obo:HP_0001680 . obo:HP_0031055 obo:IAO_0000115 "A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries, whereby the aortic arch descends on the left as normal (as opposed to right aortic arch)." ; dc:date "2017-05-27T17:24:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal branching pattern of left aortic arch" ; rdfs:subClassOf obo:HP_0011587 . obo:HP_0031056 obo:IAO_0000115 "A localized circumferential (i.e., bulges on all sides) dilatation or ballooning of a cerebral artery." ; dc:date "2017-05-27T17:29:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intracranial fusiform aneurysm" ; a owl:Class ; rdfs:label "Fusiform cerebral aneurysm" ; rdfs:subClassOf obo:HP_0004944 . obo:HP_0031057 obo:IAO_0000115 "A clearly-defined and roughly linear cleavage in the skin that usually extends to the dermis." ; dc:date "2017-05-27T17:57:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cracked skin" ; a owl:Class ; rdfs:label "Skin fissure" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0031058 obo:IAO_0000115 "Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure." ; dc:date "2017-05-28T22:14:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impairment of activities of daily living" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0031059 obo:IAO_0000115 "This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing." ; dc:date "2017-05-28T22:16:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired ability to bathe oneself" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031060 obo:IAO_0000115 "This applies to an individual who needs help with dressing or needs to be completely dressed." ; dc:date "2017-05-28T22:21:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired ability to dress oneself" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031061 obo:IAO_0000115 "This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode." ; dc:date "2017-05-28T22:22:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired toileting ability" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031062 obo:IAO_0000115 "Applies to an individual who needs help in moving from bed to chair or requires a complete transfer." ; dc:date "2017-05-28T22:23:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired transferring ability" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031063 obo:IAO_0000115 "Applies to an individual who needs partial or total help with feeding or requires parenteral feeding." ; dc:date "2017-05-28T22:24:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired feeding ability" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031064 obo:IAO_0000115 "Partial or total incontinence of bowel or bladder." ; dc:date "2017-05-28T22:29:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired continence" ; rdfs:subClassOf obo:HP_0031058 . obo:HP_0031065 dc:date "2017-05-28T22:32:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ovarian morphology" ; rdfs:subClassOf obo:HP_0000137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031066 obo:IAO_0000115 "Any anomaly of ovarian function." ; dc:date "2017-05-28T22:33:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ovarian physiology" ; rdfs:subClassOf obo:HP_0000080, obo:HP_0030012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031067 obo:IAO_0000115 "A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization." ; dc:date "2017-05-28T22:37:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Empty follicle syndrome" ; a owl:Class ; rdfs:comment "Empty follicle syndrome (EFS) has been defined as a condition in which no oocytes are retrieved from mature ovarian follicles with apparently normal follicular development and estradiol levels, after COH for an assisted reproductive technology (ART) cycle, despite repeated aspiration and flushing." ; rdfs:label "Empty ovarian follicle" ; rdfs:subClassOf obo:HP_0031066 . obo:HP_0031068 obo:IAO_0100001 "HP:0012427" ; dc:date "2017-05-28T22:50:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Increased femoral torsion" ; owl:deprecated true . obo:HP_0031069 obo:IAO_0000115 "Femoral torsion, also known as femoral rotation or femoral version, refers to the twist between the proximal and distal parts of the femur on the transverse plane. Femoral anteversion averages between 30-40 degress at birth, and between 8-14 degrees in adults. This term applies if the amount of femoral torsion deviates from this range." ; dc:date "2017-05-28T22:59:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal femoral torsion" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0031070 dc:date "2017-05-28T22:59:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Femoral retroversion" ; owl:deprecated true . obo:HP_0031071 obo:IAO_0000115 "Any anomaly of the structure of an organ ofthe endocrine system." ; dc:date "2017-05-28T23:11:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal endocrine morphology" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000949 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031072 obo:IAO_0000115 "Any anomaly of the function of the endocrine system." ; dc:date "2017-05-28T23:12:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal endocrine physiology" ; rdfs:subClassOf obo:HP_0000818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000949 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031073 obo:IAO_0000115 "An anomalous response to a test that is designed to probe the function of the endocrine system." ; dc:date "2017-05-28T23:14:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal response to endocrine stimulation test" ; rdfs:subClassOf obo:HP_0031072 . obo:HP_0031074 obo:IAO_0000115 "An anomolous response to stimulation by adminstration of the adrenocorticotropic hormone (ACTH). ACTH stimulation normally stimulates the adrenal glands to release cortisol and adrenaline." ; dc:date "2017-05-28T23:15:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal response to adrenocorticotropic-hormone stimulation test", "Abnormal response to corticotropin stimulation test" ; a owl:Class ; rdfs:comment "Corticotropin is another term for ACTH." ; rdfs:label "Abnormal response to ACTH stimulation test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031075 obo:IAO_0000115 "An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level." ; dc:date "2017-05-28T23:17:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal response to insulin tolerance test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031076 obo:IAO_0000115 "Failure of cortisol levels to respond adequately (by increasing) to the insulin tolerance test (ITT)." ; dc:date "2017-05-28T23:23:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired cortisol response to insulin stimulation test" ; rdfs:subClassOf obo:HP_0031075 . obo:HP_0031077 obo:IAO_0000115 "An anomalous response to the corticotropin releasing hormone (CRH) stimulation test. Normally,CRH is released by the hypothalamus to induce adrenocorticotropic hormone (ACTH) release by the anterior pituitary. In the stimulation test, CRH is administered intravenously and ACTH and cortisol are measured at intervals." ; dc:date "2017-05-28T23:25:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal response to CRH stimulation test" ; a owl:Class ; rdfs:label "Abnormal response to corticotropin releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031078 obo:IAO_0000115 "Failure of cortisol levels to respond adequately (by increasing) to the corticotropin releasing hormone stimulation test." ; dc:date "2017-05-28T23:29:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired cortisol response to corticotropin releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0031077 . obo:HP_0031079 obo:IAO_0000115 "Failure of growth hormone levels to respond adequately (by increasing) to the insulin tolerance test (ITT)." ; dc:date "2017-05-28T23:33:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired growth-hormone response to insulin stimulation test" ; rdfs:subClassOf obo:HP_0031075 . obo:HP_0031080 obo:IAO_0000115 "An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH)." ; dc:date "2017-05-28T23:47:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal response to glucagon stimulation test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031081 obo:IAO_0000115 "Failure of cortisol levels to respond adequately (by increasing) to the glucagon stimulation test." ; dc:date "2017-05-28T23:49:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired cortisol response to glucagon stimulation test" ; rdfs:subClassOf obo:HP_0031080 . obo:HP_0031082 obo:IAO_0000115 "Failure of growth hormone levels to respond adequately (by increasing) to the glucagon stimulation test." ; dc:date "2017-05-28T23:49:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired growth-hormone response to glucagon stimulation test" ; rdfs:subClassOf obo:HP_0031080 . obo:HP_0031083 obo:IAO_0000115 "An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors." ; dc:date "2017-05-28T23:53:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal response to hCG stimulation test" ; a owl:Class ; rdfs:label "Abnormal response to human chorionic gonadotrophin stimulation test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031084 obo:IAO_0000115 "An abnormally high increase in insulin levels following a glucagon stimulation test." ; dc:date "2017-05-29T00:02:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Excessive insulin response to glucagon test" ; rdfs:subClassOf obo:HP_0031080 . obo:HP_0031085 obo:IAO_0000115 "A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status." ; dc:date "2017-05-29T00:10:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased prealbumin level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031086 obo:IAO_0000115 "Undescended or ectopic ovaries are characterized by the attachment of the upper pole of the ovary to an area above the level of the common iliac vessels." ; dc:date "2017-05-29T00:18:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Undescended ovary" ; a owl:Class ; rdfs:label "Ectopic ovary" ; rdfs:subClassOf obo:HP_0031065 . obo:HP_0031087 obo:IAO_0000115 "The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur." ; dc:date "2017-05-29T00:29:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent adolescent growth spurt" ; a owl:Class ; rdfs:label "Absent pubertal growth spurt" ; rdfs:subClassOf obo:HP_0001510 . obo:HP_0031088 obo:IAO_0000115 "Persistent vaginal dryness." ; dc:date "2017-05-29T00:50:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vaginal dryness" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0031089 obo:IAO_0000115 "Swelling related to fluid accumulation within the palate." ; dc:date "2017-05-29T00:54:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Palatal oedema", "Palate edema", "Palate oedema" ; a owl:Class ; rdfs:label "Palatal edema" ; rdfs:subClassOf obo:HP_0000174 . obo:HP_0031090 obo:IAO_0000115 "Fingers appear swollen and plump owing to inflammation of the complete finger." ; dc:date "2017-05-29T00:57:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sausage fingers" ; a owl:Class ; rdfs:label "Finger dactylitis" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0031091 obo:IAO_0000115 "Toes appear swollen and plump owing to inflammation of the complete toe." ; dc:date "2017-05-29T01:00:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sausage toes" ; a owl:Class ; rdfs:label "Toe dactylitis" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0031092 obo:IAO_0000115 "Swelling of the hand at the knuckles, that gives the fingers a spindle shape (i.e., a round stick with tapered end and a broader base)." ; dc:date "2017-05-29T01:07:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spindle-shaped finger" ; rdfs:subClassOf obo:HP_0001167 . obo:HP_0031093 obo:IAO_0000115 "Any anomaly of the structure of the breast." ; dc:date "2017-06-30T15:41:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal breast morphology" ; rdfs:subClassOf obo:HP_0000769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031094 obo:IAO_0000115 "Any anomaly of the function of the breast." ; dc:date "2017-06-30T15:42:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal breast physiology" ; rdfs:subClassOf obo:HP_0000769 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031095 obo:IAO_0000115 "Any anomaly of the structure of the humerus." ; dc:date "2017-05-30T01:22:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal humerus morphology" ; rdfs:subClassOf obo:HP_0003063, obo:HP_0011314, obo:HP_0040070 . obo:HP_0031096 obo:IAO_0000115 "A decrease in the amount of mineralized bone in one or more vertebrae compared with that expected for a given developmental age." ; dc:date "2017-05-30T02:04:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed vertebral ossification" ; rdfs:subClassOf obo:HP_0100569 . obo:HP_0031097 obo:IAO_0000115 "Any deviation from the normal amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland." ; dc:date "2017-05-30T02:12:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal TSH level", "Abnormal circulating thyrotropin concentration", "Abnormal thyrotropin level" ; a owl:Class ; rdfs:label "Abnormal thyroid-stimulating hormone level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0031098 obo:IAO_0000115 "Reduced amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland." ; dc:date "2017-05-30T02:13:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased plasma TSH", "Decreased thyrotropin level" ; a owl:Class ; rdfs:label "Decreased thyroid-stimulating hormone level" ; rdfs:subClassOf obo:HP_0031097 . obo:HP_0031099 obo:IAO_0000115 "Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone." ; dc:date "2017-05-30T02:18:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating inhibin level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0031100 obo:IAO_0000115 "A reduced concentration of inhibin B in the blood." ; dc:date "2017-05-30T02:19:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Inhibin B, a dimer with an alpha and a betaB subunit, is produced exclusively by the testis and controls FSH secretion via a negative feedback mechanism." ; rdfs:label "Decreased inhibin B level" ; rdfs:subClassOf obo:HP_0031099 . obo:HP_0031101 obo:IAO_0000115 "Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases." ; dc:date "2017-05-30T02:34:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal antimullerian hormone level" ; a owl:Class ; rdfs:label "Abnormal circulating antimullerian hormone concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0031102 obo:IAO_0000115 "An elevation above the normal range of the antimullerian hormone in the circulation." ; dc:date "2017-05-30T02:37:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased antimullerian hormone level", "Increased plasma AMH" ; a owl:Class ; rdfs:label "Increased circulating antimullerian hormone concentration" ; rdfs:subClassOf obo:HP_0031101 . obo:HP_0031103 obo:IAO_0000115 "A reduction below the normal range of the antimullerian hormone in the circulation." ; dc:date "2017-05-30T02:37:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Mullerian hormone low", "Decreased antimullerian hormone level", "Decreased plasma AMH" ; a owl:Class ; rdfs:label "Decreased cirrculating antimullerian hormone circulation" ; rdfs:subClassOf obo:HP_0031101 . obo:HP_0031104 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor." ; dc:date "2017-05-30T02:42:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Insulin receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0031105 obo:IAO_0000115 "Any anomaly of the structure of the uterus" ; dc:date "2017-05-30T02:52:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal uterus morphology" ; rdfs:subClassOf obo:HP_0000130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031106 obo:IAO_0000115 "An abnormality of the uterus characterized by a normal uterine outline but with an abnormal T-shaped uterine cavity with narrowing cavity due to thickened lateral walls with a correlation 2/3 uterine corpus and 1/3 cervix. The abnormlaity is said to resemble the letter T in hysterosalpingographic imaging." ; dc:date "2017-05-30T02:53:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "T-shaped uterus" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0031107 obo:IAO_0000115 "Reduced width of the cross sectional diameter of the fibula." ; dc:date "2017-05-30T03:09:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thin fibula" ; a owl:Class ; rdfs:label "Decreased fibular diameter" ; rdfs:subClassOf obo:HP_0002991 . obo:HP_0031108 obo:IAO_0000115 "A lack of strength in the triceps muscle, which normally is responsible for extending (straightening) the elbow and mediating certain shoulder movements." ; dc:date "2017-06-09T10:13:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triceps weakness" ; rdfs:subClassOf obo:HP_0008997 . obo:HP_0031109 obo:IAO_0000115 "Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant." ; dc:date "2017-06-30T15:43:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lactation incapacity" ; a owl:Class ; rdfs:label "Agalactia" ; rdfs:subClassOf obo:HP_0031094 . obo:HP_0031110 obo:IAO_0000115 "As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure." ; dc:date "2017-06-30T16:02:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Twin to twin transfusion syndrome" ; a owl:Class ; rdfs:label "Twin-to-twin transfusion" ; rdfs:subClassOf obo:HP_0034059 . obo:HP_0031111 obo:IAO_0000115 "A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin." ; dc:date "2017-08-31T23:10:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin hamartoma" ; a owl:Class ; rdfs:label "Cutaneous hamartoma" ; rdfs:subClassOf obo:HP_0010566 . obo:HP_0031117 obo:IAO_0000115 "A type of bicuspid aortic valve (BAV) characterized by two equal-sized cusps, with no raphe and only two commissures. There is a lateral arrangement of the free edge of the cusps. Note that this differs from some other forms of BAV in which there are three commissures and two of the three cusps are joined by a raphe forming two functional leaflets. This type of BAV often is associated with aortic stenosis." ; dc:date "2017-06-10T11:41:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Purely bicuspid aortic valve" ; rdfs:subClassOf obo:HP_0001647 . obo:HP_0031118 obo:IAO_0000115 "A type of bicuspid aortic valvue (BAV) characterized by the presence of a single raphe that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps, resulting in two leaflets of unequal size." ; dc:date "2017-06-10T11:46:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Single raphe bicuspid aortic valve" ; rdfs:subClassOf obo:HP_0001647 . obo:HP_0031119 obo:IAO_0000115 "A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and left cusps (RL fusion pattern). This results in two leaflefts with an anterior-posterior leaflet orientation (also called the typical pattern). There is thus one completely developed noncoronary cusp, two completely developed commissures, and one raphe between the underdeveloped left and right coronary cusps extending to the corresponding malformed commissure." ; dc:date "2017-06-10T11:48:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bicuspid aortic valve with right-left cusp fusion" ; rdfs:subClassOf obo:HP_0031118 . obo:HP_0031120 obo:IAO_0000115 "A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and noncoronary cusps (RN fusion pattern). This results in two leaflets with right-left leaflet orientation (also called the atypical pattern). There is thus one completely developed left cusp, two completely developed commissures, and one raphe between the underdeveloped right and noncoronary coronary cusps extending to the corresponding malformed commissure." ; dc:date "2017-06-10T12:00:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bicuspid aortic valve with right-noncoronary cusp fusion" ; rdfs:subClassOf obo:HP_0031118 . obo:HP_0031121 obo:IAO_0000115 "A type of bicuspid aortic valve (BAV) characterized by a single raphe between the left and noncoronary cusps (LN fusion pattern). There is thus one completely developed right cusp, two completely developed commissures, and one raphe between the underdeveloped left and noncoronary coronary cusps extending to the corresponding malformed commissure." ; dc:date "2017-06-10T12:04:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bicuspid aortic valve with left-noncoronary cusp fusion" ; rdfs:subClassOf obo:HP_0031118 . obo:HP_0031122 obo:IAO_0000115 "A type of bicuspid aortic valvue (BAV) characterized by the presence of two raphes that each extend from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV has developmental anlagen of three cusps, commissures, and sinuses, but two commissures are more or less malformed and obliterated, giving rise to a raphe, a fibrous ridge, which extends from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV is typically associated with a high degree of aortic stenosis." ; dc:date "2017-06-10T12:06:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Two-raphe bicuspid aortic valve" ; rdfs:subClassOf obo:HP_0001647 . obo:HP_0031123 obo:IAO_0000115 "Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis." ; dc:date "2017-06-10T12:26:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent gastroenteritis" ; rdfs:subClassOf obo:HP_0004798 . obo:HP_0031124 obo:IAO_0000115 "Decreased cell membrane concentration of thromboxane A2 receptor that is stimulated by thromboxane A2 (TBXA2)." ; dc:date "2017-06-10T12:30:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased platelet thromboxane A2 receptor" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0031125 obo:IAO_0000115 "Decreased cell membrane concentration of alpha-2A adrenergic receptor that is stimulated by epinephrine." ; dc:date "2017-06-10T12:30:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased platelet alpha-2A-adrenergic receptor" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0031126 obo:IAO_0000115 "Platelets contain contractile proteins (actin and myosin) that induce clot retraction. As the platelets contract, they pull on the surrounding fibrin strands, squeezing serum form the mass, compacting the clot and drawing the ruptured edges of the blood vessel more closely together. Clot retraction is directly proportional to the platelet count and inversely proportional to the fibrinogen concentration." ; dc:date "2017-06-10T12:31:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired clot retraction" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0031127 obo:IAO_0000115 "Abnormal response to convulxin as manifested by reduced or lacking aggregation of platelets upon addition of convulxin." ; dc:date "2017-06-10T12:31:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired convulxin-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0031128 obo:IAO_0000115 "Abnormal response to collagen-related peptide (CRP) as manifested by reduced or lacking aggregation of platelets upon addition of CRP." ; dc:date "2017-06-10T12:32:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired collagen-related peptide-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0031129 obo:IAO_0000115 "Abnormal response to phorbol myristate acetate (PMA) as manifested by reduced or lacking aggregation of platelets upon addition of PMA." ; dc:date "2017-06-10T12:32:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired phorbol myristate acetate-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0031130 obo:IAO_0000115 "Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore." ; dc:date "2017-06-10T12:33:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired Ca ionophore-induced platelet aggregation", "Impaired Ca2+ ionophore-induced platelet aggregation" ; a owl:Class ; rdfs:label "Impaired calcium ionophore-induced platelet aggregation" ; rdfs:subClassOf obo:HP_0003540 . obo:HP_0031131 obo:IAO_0000115 "An abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement." ; dc:date "2017-06-10T12:34:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal platelet phosphatidylserine exposure" ; rdfs:subClassOf obo:HP_0011869 . obo:HP_0031132 obo:IAO_0000115 "Reduced binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry." ; dc:date "2017-06-10T12:39:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired annexin V binding to platelet phosphatidylserine" ; rdfs:subClassOf obo:HP_0031131 . obo:HP_0031133 obo:IAO_0000115 "Elevated binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry." ; dc:date "2017-06-10T12:54:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased annexin V binding to platelet phosphatidylserine" ; rdfs:subClassOf obo:HP_0031132 . obo:HP_0031134 obo:IAO_0000115 "A developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum." ; dc:date "2017-06-10T13:02:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cor triatrium sinister" ; rdfs:subClassOf obo:HP_0010774 . obo:HP_0031135 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a trauma (injury to tissue)." ; dc:date "2017-06-10T13:29:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Physical trauma triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by physical trauma" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0031136 obo:IAO_0000115 "A reduced amount of the enzyme acrosin in the sperm head acrosome. The acrosome is an organelle in the anterior half of the head of spermatozoa, and acrosin is a protease that contributes to the digestation of the zona pellucida in the fertilization process." ; dc:date "2017-06-10T15:21:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased acrosin in sperm head" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0031137 obo:IAO_0000115 "Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material." ; dc:date "2017-06-10T15:30:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Storage in hepatocytes" ; rdfs:subClassOf obo:HP_0034644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_50860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000182 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031138 obo:IAO_0000115 "A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP)." ; dc:date "2017-06-10T18:39:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal B-type natriuretic peptide level" ; a owl:Class ; rdfs:comment "Increased plasma levels of circulating natriuretic peptides (NP) have been described in patients with congestive heart failure and are directly proportional to the severity of congestive heart failure as classified by the New York Heart Association criteria." ; rdfs:label "Abnormal B-type natriuretic peptide concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031139 obo:IAO_0000115 "A type of rest posture in an infant that indicated a generalized reduction in muscle tone. The hips are flexed and the legs are abducted to an extent that causes the lateral thigh to rest upon the supporting surface. This posture is said to resemble the legs of a frog." ; dc:date "2017-06-10T22:38:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Frog-leg posture" ; rdfs:subClassOf obo:HP_0001252 . obo:HP_0031140 obo:IAO_0000115 "An abnormal appearance of the liver or any of its components on sonography (ultrasound)." ; dc:date "2017-06-11T19:18:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal liver sonography" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0031141 obo:IAO_0000115 "Increased echogenicity of liver tissue on sonography, manifested as an increased amount of white on the screen of the sonography device." ; dc:date "2017-06-11T19:19:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperechogenic liver" ; a owl:Class ; rdfs:label "Increased hepatic echogenicity" ; rdfs:subClassOf obo:HP_0031142 . obo:HP_0031142 obo:IAO_0000115 "Any deviation from the normal degree of echogenicity of the liver on sonography. Echogenicity refers to the ability of a tissue to reflect or transmit ultrasound waves in the context of surrounding tissues. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. Based on echogenicity, a structure can be characterized as hyperechoic (white on the screen), hypoechoic (gray on the screen) and anechoic (black on the screen)." ; dc:date "2017-06-11T19:20:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal hepatic echogenicity" ; rdfs:subClassOf obo:HP_0031140 . obo:HP_0031143 obo:IAO_0000115 "Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device." ; dc:date "2017-06-11T19:23:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoechogenic liver" ; a owl:Class ; rdfs:label "Decreased hepatic echogenicity" ; rdfs:subClassOf obo:HP_0031142 . obo:HP_0031144 obo:IAO_0000115 "The appearance of the liver in sonographic images is normally uniform. This term applies when there is an irregular or non-uniform appearance of the liver parenchyma in liver sonography." ; dc:date "2017-06-11T19:31:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coarsened hepatic echotexture" ; rdfs:subClassOf obo:HP_0031140 . obo:HP_0031145 obo:IAO_0000115 "An abnormal echotexture visible in liver ultrasound manifesting as a diffuse hyperechoic liver echotexture with multiple, small hypoechoic lesions. The appearance is said to resemble a starry sky (multiple white spots on a dark background)." ; dc:date "2017-06-11T19:50:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Starry sky appearance on hepatic sonography" ; rdfs:subClassOf obo:HP_0031140 . obo:HP_0031146 obo:IAO_0000115 "An abnormality of swallowing characterized by reduced tongue coordination to form bolus after chewing. Food material spreads over the oral cavity instead of being concentrated into a bolus that is easily swallowed." ; dc:date "2017-06-11T20:31:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired oral bolus formation" ; rdfs:subClassOf obo:HP_0002015 . obo:HP_0031150 obo:IAO_0000115 "Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions." ; dc:date "2017-06-18T13:09:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "VMA" ; a owl:Class ; rdfs:label "Vitreomacular adhesion" ; rdfs:subClassOf obo:HP_0001103 . obo:HP_0031151 obo:IAO_0000115 "Vitreomacular traction is characterized by anomalous posterior vitreous detachment accompanied by anatomic distortion of the fovea, which may include pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid. Vitreomacular traction can be subclassified by the diameter of vitreous attachment to the macular surface as measured by OCT, with attachment of 1500 micrometers or less defined as focal and attachment of more than 1500 micrometers as broad." ; dc:date "2017-06-18T13:11:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "VMT" ; a owl:Class ; rdfs:label "Vitreomacular traction" ; rdfs:subClassOf obo:HP_0001103 . obo:HP_0031152 obo:IAO_0000115 "Full-thickness macular hole (FTMH) is defined as a foveal lesion with interruption of all retinal layers from the internal limiting membrane to the retinal pigment epithelium. Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than vitreomacular traction. Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of vitreomacular traction." ; dc:date "2017-06-18T13:12:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "FTMH" ; a owl:Class ; rdfs:label "Full-thickness macular hole" ; rdfs:subClassOf obo:HP_0011508 . obo:HP_0031153 obo:IAO_0000115 "Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane." ; dc:date "2017-06-18T13:16:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Membranous anomaly", "Membranous vitreous", "Membranous vitreous phenotype" ; a owl:Class ; rdfs:label "Membranous vitreous appearance" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0031154 obo:IAO_0000115 "Vitreous humor of the eye displaying beaded bundles of irregular diameters." ; dc:date "2017-06-18T13:18:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Beaded vitreous appearance" ; rdfs:subClassOf obo:HP_0004327 . obo:HP_0031155 obo:IAO_0000115 "An abnormal increase in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record." ; dc:date "2017-06-18T13:19:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased Arden ratio of EOG" ; a owl:Class ; rdfs:label "Increased Arden ratio of electrooculogram" ; rdfs:subClassOf obo:HP_0030454 . obo:HP_0031156 obo:IAO_0000115 "Decreased platelet cell membrane concentration of glycoprotein Ib." ; dc:date "2017-06-18T13:22:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased platelet glycoprotein Ib" ; rdfs:subClassOf obo:HP_0011878 . obo:HP_0031157 obo:IAO_0000115 "An abnormal connection between a carotid artery and the cavernous sinus." ; dc:date "2017-06-18T13:31:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Caroticocavernous fistula" ; a owl:Class ; rdfs:comment "The cavernous sinus is a dural venous sinus in the skull that is adjacent to the temporal bone and the sphenoid bone. The carotid cavernous fistula is a type of arteriovenous fistula that causes arterial blood to enter the cavernous sinus. Clinical findings include head, ocular, and facial pain, pulsatile proptosis, chemosis, periorbital edema, conjunctival injection, double vision, glaucoma and, visual loss." ; rdfs:label "Carotid cavernous fistula" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0031158 obo:IAO_0000115 "An atrophic scar (fibrous connective tissue resulting from incomplete healing of a wound) that has stretched (gotten wider), a manifestation of tissue fragility." ; dc:date "2017-06-18T13:39:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Widened atrophic scar" ; rdfs:subClassOf obo:HP_0001075 . obo:HP_0031159 obo:IAO_0000115 "A reduction in the thickness of Descemet's membrane." ; dc:date "2017-06-18T13:55:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thinning of Descemet membrane" ; rdfs:subClassOf obo:HP_0011490 . obo:HP_0031160 obo:IAO_0000115 "Impaired egress of mature neutrophils from bone marrow causing neutropenia." ; dc:date "2017-06-18T14:13:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The word myelo-kathexis is derived from the Greek words for marrow (myelo) retention (kathexis). Unlike other forms of severe neutropenia, myelokathexis is characterized by granulocytic hyperplasia in the bone marrow, which contains neutrophils with cytoplasmic vacuoles, nuclear hypersegmentation, and pyknotic nuclear lobes connected by thin filaments." ; rdfs:label "Myelokathexis" ; rdfs:subClassOf obo:HP_0012135 . obo:HP_0031161 obo:IAO_0000115 "An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2017-06-18T17:37:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced brain glutamate level by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0031162 obo:IAO_0000115 "Delay or absence of the swallow response, reflexes triggered by the contact the food bolus makes with the anterior faucial pillars." ; dc:date "2017-06-18T17:51:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In the involuntary pharyngeal phase, the soft palate rises to close the nasopharynx and prevent nasal regurgitations. The hyoid bone rises, bringing the larynx up, while the epiglottis closes the entrance to the larynx. The base of the tongue contacts the pharyngeal wall, at the same time as the hyoid moves forward, coinciding with the relaxation of the cricopharyngeus muscle and the opening of the upper esophageal sphincter." ; rdfs:label "Impaired oropharyngeal swallow response" ; rdfs:subClassOf obo:HP_0002015 . obo:HP_0031163 obo:IAO_0000115 "Reduced bone mineral density of the femur." ; dc:date "2017-06-18T17:59:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low femur bone density" ; a owl:Class ; rdfs:comment "Osteopenia is defined as BMD between 1 standard deviation (SD) and 2.5 SD below the mean of the young reference group. Osteoporosis is defined as BMD 2.5 SD or more below the mean of the young reference group." ; rdfs:label "Low femoral bone density" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0031164 obo:IAO_0000115 "Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone." ; dc:date "2017-06-18T18:03:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Growth resumption lines", "Harris lines" ; a owl:Class ; rdfs:label "Growth arrest lines" ; rdfs:subClassOf obo:HP_0031367 . obo:HP_0031165 obo:IAO_0000115 "Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations)." ; dc:date "2017-06-18T18:13:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multifocal onset seizures" ; a owl:Class ; rdfs:label "Multifocal seizures" ; rdfs:subClassOf obo:HP_0007359 . obo:HP_0031166 obo:IAO_0000115 "Involuntary, fine, continuous, undulating contractions of the eyelid." ; dc:date "2017-06-18T19:03:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myokymia orbicularis", "Orbicularis myokymia" ; a owl:Class ; rdfs:label "Eyelid myokymia" ; rdfs:subClassOf obo:HP_0002411 . obo:HP_0031167 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating or drinking foods rich in potassium." ; dc:date "2017-06-18T19:18:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Potassium-rich food triggered symptoms", "Triggered by ingestion of K-rich food" ; a owl:Class ; rdfs:comment "In contrast to paramyotonia congenita or hyperkalaemic periodic paralysis, potassium-aggravated myotonias (PAM) patients show no muscle weakness and hardly any cold sensitivity. However, they show an aggravation of their myotonia after ingestion of potassium, which distinguishes them from patients with chloride channelopathies." ; rdfs:label "Triggered by ingestion of potassium-rich food" ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0031169 obo:IAO_0000115 "A pregnancy that extends to 42 weeks of gestation or beyond." ; dc:date "2017-06-18T19:54:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term can apply to a child born of a postterm pregancy." ; rdfs:label "Postterm pregnancy" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0031170 obo:IAO_0000115 "Fetal masculinization of female external genitalia." ; dc:date "2017-06-18T19:57:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Female foetal virilization" ; a owl:Class ; rdfs:comment "This anomaly can be observed with etiologies including 21-hydroxylase deficiency, pregnancy luteomas, and maternal intake of progesterones." ; rdfs:label "Female fetal virilization" ; rdfs:subClassOf obo:HP_0034242 . obo:HP_0031171 obo:IAO_0000115 "A bony projection (spur, osteophyte) originating from the femur, often in the medial femoral neck." ; dc:date "2017-06-18T20:02:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spurring of femur" ; a owl:Class ; rdfs:label "Femoral spur" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0031172 obo:IAO_0000115 "A variant of retinitis pigmentosa in which there is a regional distribution of the retinal degeneration." ; dc:date "2017-06-18T20:05:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sectoral retinitis pigmentosa" ; rdfs:subClassOf obo:HP_0000510 . obo:HP_0031173 obo:IAO_0000115 "A bony projection (spur, osteophyte) originating from the tibia." ; dc:date "2017-06-18T20:06:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spurring of tibiae" ; a owl:Class ; rdfs:label "Tibial spur" ; rdfs:subClassOf obo:HP_0002992 . obo:HP_0031174 obo:IAO_0000115 "An anomaly of the patella characterized by two layers visible on lateral knee X-ray such that one layer is in front of the other in the sagittal orientation (See Figure 2A and 3B of PMID:12966518). This finding persists into adulthood." ; dc:date "2017-06-18T20:08:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be observed in Multiple epiphyseal dysplasia type 4. It is distinct from bipartite patella, which is characterized by an unfused accessory ossification center at the superolateral aspect of the patella. Double layer patella appears to be caused by the presence of several patellar ossification centers." ; rdfs:label "Double-layered patella" ; rdfs:subClassOf obo:HP_0003045 . obo:HP_0031175 obo:IAO_0000115 "A developmental defect characterized by agenesis of one or more vertebral bodies of the cervical spine." ; dc:date "2017-06-18T20:20:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent cervical vertebra" ; rdfs:subClassOf obo:HP_0008465 . obo:HP_0031176 obo:IAO_0000115 "A developmental defect characterized by agenesis of one or more vertebral bodies of the thoracic spine." ; dc:date "2017-06-18T20:20:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent thoracic vertebra" ; rdfs:subClassOf obo:HP_0008465 . obo:HP_0031177 obo:IAO_0000115 "Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion." ; dc:date "2017-06-18T20:25:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Finger flexor weakness" ; rdfs:subClassOf obo:HP_0030237 . obo:HP_0031178 obo:IAO_0000115 "Head is bent in the posterior direction in a permanent fashion." ; dc:date "2017-06-18T20:28:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fixed head retroflexion" ; rdfs:subClassOf obo:HP_0000234 . obo:HP_0031179 obo:IAO_0000115 "Resistance of the extensor muscles of the neck to being bent forwards (i.e., impaired neck flexion) as a result of muscle spasm of the extensor muscles of the neck. Nuchal rigidity is not a fixed rigidity. Nuchal rigidity has been used as a bedside test for meningism, although its sensitivity for this purpose has been debated." ; dc:date "2017-06-18T20:41:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Meningism" ; a owl:Class ; rdfs:comment "Meningism is resistance to neck flexion due to painful spasm of extensor muscles resulting from meningeal irritation. The diagnosis of meningism is made in someone whose symptoms simulate meningitis, but in which no actual inflammation of these membranes is present. Nuchal rigidity can thus be observed in individuals with meningitis or with meningism." ; rdfs:label "Nuchal rigidity" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0031180 obo:IAO_0000115 "An expanding erythematous (red) skin lesion, usually round or oval, by definition at least 5 cm in size (in largest diameter)." ; dc:date "2017-06-18T20:57:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Erythema chronicum migrans" ; a owl:Class ; rdfs:comment "Erythema migrans develops at the site of the deposition of Borrelia burgdorferi 7 to 14 days (range, 1-36 days) following the detachment of certain Ixodes ticks. The most important differential diagnosis is a localized and transient inflammatory reaction to the bite of an arthropod that is not associated with infection and resolves spontaneously within a day or two, and is usually less than 5 cm in size." ; rdfs:label "Erythema migrans" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0031181 obo:IAO_0000115 "Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution." ; dc:date "2017-06-18T21:02:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be a manifestation of glucagonoma and other cancers." ; rdfs:label "Necrolytic migratory erythema" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0031185 obo:IAO_0000115 "An elevated level of circulating N-terminal part of the prohormone of B-type natriuretic peptide (BNP)." ; dc:date "2017-06-21T10:30:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased NT-proBNP level" ; a owl:Class ; rdfs:label "Increased circulating NT-proBNP concentration" ; rdfs:subClassOf obo:HP_0031138 . obo:HP_0031186 obo:IAO_0000115 "An abnormality of the concentration of deoxycorticosterone in the blood. Deoxycorticosterone comprises 11-deoxycorticosterone and 21-deoxycorticosterone." ; dc:date "2017-06-21T10:39:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating deoxycorticosterone level" ; rdfs:subClassOf obo:HP_0012112 . obo:HP_0031187 obo:IAO_0000115 "An abnormality of the concentration of pregnenolone in the blood." ; dc:date "2017-06-21T10:45:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of circulating pregnenolone level" ; a owl:Class ; rdfs:comment "Neurosteroids are steroids synthesized within the central nervous system as well as in other steroidogenic organs/tissues. In contrary with the classical actions through intracellular receptors, extensive evidence has established that neurosteroids can exert rapid, potent actions at the cell membrane via allosteric interactions with the GABAA receptor. Pregnenolone is a naturally occurring neurosteroid directly metabolized from cholesterol and the precursor of virtually all neurosteroids." ; rdfs:label "Abnormal circulating pregnenolone concentration" ; rdfs:subClassOf obo:HP_0033799 . obo:HP_0031188 obo:IAO_0000115 "A buildup of fluid that causes swelling in the soft tissues of the genital area." ; dc:date "2017-06-24T12:59:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Genital oedema" ; a owl:Class ; rdfs:label "Genital edema" ; rdfs:subClassOf obo:HP_0000969 . obo:HP_0031189 obo:IAO_0000115 "A condition in which the affected individual cannot extend the wrist, which hangs flaccidly." ; dc:date "2017-06-24T13:25:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Wrist drop can be caused by radial nerve palsy." ; rdfs:label "Wrist drop" ; rdfs:subClassOf obo:HP_0003484 . obo:HP_0031190 obo:IAO_0000115 "Numerous lymphocytes surrounding blood vessels in the superfical part of the dermis." ; dc:date "2017-06-24T14:01:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Superficial perivascular inflammatory infiltrate" ; a owl:Class ; rdfs:label "Superficial dermal perivascular inflammatory infiltrate" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0031191 obo:IAO_0000115 "Numerous lymphocytes surrounding blood vessels in the deep part of the dermis." ; dc:date "2017-06-24T14:07:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Deep perivascular inflammatory infiltrate" ; a owl:Class ; rdfs:label "Deep dermal perivascular inflammatory infiltrate" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0031192 obo:IAO_0000115 "Any structural anomaly of the muscular columns which project from the inner surface of the left ventricle of the heart (cardiac trabeculae, trabeculae carneae)." ; dc:date "2017-06-24T14:10:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of left ventricular trabeculae" ; rdfs:subClassOf obo:HP_0030681 . obo:HP_0031193 obo:IAO_0000115 "Any structural anomaly of the muscular columns which project from the inner surface of the right ventricle of the heart (cardiac trabeculae, trabeculae carneae)." ; dc:date "2017-06-24T14:10:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal morphology of right ventricular trabeculae" ; rdfs:subClassOf obo:HP_0030681 . obo:HP_0031194 obo:IAO_0000115 "An increased density (number and tightness) of the muscular columns which project from the inner surface of the left ventricles of the heart (cardiac trabeculae, trabeculae carneae)." ; dc:date "2017-06-24T14:13:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased density of left ventricular trabeculae" ; rdfs:subClassOf obo:HP_0031192 . obo:HP_0031195 obo:IAO_0000115 "An increased number and density of the trabeculae in the apex (tip) of the left ventricle." ; dc:date "2017-06-24T14:15:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Apical hypertrabeculation of the left ventricle" ; rdfs:subClassOf obo:HP_0031192 . obo:HP_0031196 obo:IAO_0000115 "Reduced thickness of the outer, dense layer of the myocardium." ; dc:date "2017-06-24T14:16:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The myocardium compact layer is only in the left ventricle." ; rdfs:label "Thin myocardium compact layer" ; rdfs:subClassOf obo:HP_0031192 . obo:HP_0031197 obo:IAO_0000115 "A type of urinary cast composed of cells incorporated in a protein matrix. The cells can be those found in the urinary sediment (erythrocytes, leuklocytes, renal tubular epithelial cells)." ; dc:date "2017-06-27T10:50:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cellular casts" ; a owl:Class ; rdfs:label "Cellular urinary casts" ; rdfs:subClassOf obo:HP_0012615 . obo:HP_0031198 obo:IAO_0000115 "A type of cellular urinary cast composed of renal tubular epithelial cells." ; dc:date "2017-06-27T10:53:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Renal tubular epithelial cell casts can be observed in disorders including renal tubular necrosis, cytomegalovirus and other viral infections, kidney transplant rejection." ; rdfs:label "Renal tubular epithelial cell casts" ; rdfs:subClassOf obo:HP_0031197 . obo:HP_0031199 obo:IAO_0000115 "A type of urinary cast composed of a proteinaceous matrix without a substantial number of cells." ; dc:date "2017-06-27T10:55:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acellular casts" ; a owl:Class ; rdfs:label "Acellular urinary casts" ; rdfs:subClassOf obo:HP_0012615 . obo:HP_0031200 obo:IAO_0000115 "A type of acellular urinary cast that are composed only of Tamm-Horsfall glycoprotein, a fact which explains their low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends." ; dc:date "2017-06-27T11:00:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyaline casts" ; rdfs:subClassOf obo:HP_0031199 . obo:HP_0031201 obo:IAO_0000115 "A type of acelluar casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented." ; dc:date "2017-06-27T11:06:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "It has been demonstrated that in patients with proteinuria, fine granules contain ultrafiltered proteins which have been reabsorbed by tubular cells, whilst in non-proteinuric patients coarse granules probably derive from the degeneration of cellular elements, such as leukocytes and renal epithelial cells present in the tubular lumen during cast formation." ; rdfs:label "Granular casts" ; rdfs:subClassOf obo:HP_0031199 . obo:HP_0031202 obo:IAO_0000115 "A type of acellular urinary casts that display a melted wax (waxy) appearance, which gives them a high refractive index. They are frequently dark, with blunt extremities, indented and cracked edges and a large size, which is often several times that of other types of casts." ; dc:date "2017-06-27T11:08:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Waxy casts" ; rdfs:subClassOf obo:HP_0031199 . obo:HP_0031203 obo:IAO_0000115 "A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarised light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses." ; dc:date "2017-06-27T11:10:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The presence of fatty casts in urine may be associated with heavy proteinuria in patients with nephrotic syndrome." ; rdfs:label "Fatty casts" ; rdfs:subClassOf obo:HP_0031199 . obo:HP_0031204 obo:IAO_0000115 "A type of urinary cast that contain bacteria. Bacterial casts can be difficult to identify and can be distinguished from other types of casts using phase contrast microscopy. Bacterial casts are diagnostic of acute pyelonephritis or intrinsic renal infection." ; dc:date "2017-06-27T11:12:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bacterial cell casts" ; rdfs:subClassOf obo:HP_0012615 . obo:HP_0031205 obo:IAO_0000115 "Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins." ; dc:date "2017-06-29T11:32:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced leukocyte acid lipase activity" ; a owl:Class ; rdfs:comment "Samples from patients with Wolman Disease display extremely low or unmeasurable levels of lysosomal acid lipase (LAL) activity. Samples from patients with cholesteryl ester storage disease can display residual activities in the 5 to ten percent range." ; rdfs:label "Reduced lysosomal acid lipase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0031206 obo:IAO_0000115 "Abnormally bright T2 signal from the striatum on brain magnetic resonance imaging." ; dc:date "2017-06-29T12:15:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Striatal T2 hyperintensity" ; rdfs:subClassOf obo:HP_0007183, obo:HP_0010994 . obo:HP_0031207 obo:IAO_0000115 "A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size." ; dc:date "2017-07-02T10:39:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hemangioma of the liver", "Liver hemangioma" ; a owl:Class ; rdfs:comment "Hepatic hemangiomas are considered the most common benign mesenchymal hepatic tumors. They can be divided into two major groups: capillary hemangiomas and cavernous hemangiomas." ; rdfs:label "Hepatic hemangioma" ; rdfs:subClassOf obo:HP_0002896, obo:HP_0410266 . obo:HP_0031208 obo:IAO_0000115 "An increased concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones." ; dc:date "2017-07-02T10:50:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased pituitary glycoprotein alpha subunit level", "Increased pituitary glycoprotein polypeptide alpha subunit level" ; a owl:Class ; rdfs:label "Increased pituitary glycoprotein hormone alpha subunit level" ; rdfs:subClassOf obo:HP_0032481 . obo:HP_0031209 obo:IAO_0000115 "Reduction in the level of lipoprotein lipase in the blood." ; dc:date "2017-07-02T10:57:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased lipoprotein lipase level" ; a owl:Class ; rdfs:comment "Decreased plasma lipoprotein lipase activity is associated with delayed clearance of triglyceride-rich lipoproteins and low fasting HDL cholesterol." ; rdfs:label "Decreased circulating lipoprotein lipase concentration" ; rdfs:subClassOf obo:HP_0033477 . obo:HP_0031210 obo:IAO_0000115 "A deviation from the normal concentration of hyaluronic acid in the blood." ; dc:date "2017-07-02T11:00:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Serum hyaluronic acid (HA) is considered to be a marker of liver function. HA is a glycosaminoglycan that is rapidly cleared from the circulation by the liver via receptor mediated endocytosis into sinusoidal endothelial cells." ; rdfs:label "Abnormal circulating hyaluronic acid concentration" ; rdfs:subClassOf obo:HP_0011012 . obo:HP_0031211 obo:IAO_0000115 "An elevated concentration of circulating cholesterol esters, which are fatty acid esters of cholesterol and make up about two-thirds of total plasma cholesterol." ; dc:date "2017-07-02T11:04:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0500010" ; oboInOwl:hasExactSynonym "Elevated cholesteryl ester level", "Increased cholesterol esters", "Increased cholesteryl esters" ; a owl:Class ; rdfs:comment "The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis." ; rdfs:label "Elevated cholesterol ester level" ; rdfs:subClassOf obo:HP_0003107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17002 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031212 dc:date "2017-07-02T11:20:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating progesterone level" ; rdfs:subClassOf obo:HP_0033799 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17026 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031213 obo:IAO_0000115 "An increased level of 17-hydroxyprogesterone in the blood. 17-hydroxyprogesterone is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase." ; dc:date "2017-07-02T11:21:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating 17-OHP", "Elevated circulating 17-hydroxyprogesterone" ; a owl:Class ; rdfs:comment "An inherited deficiency of 21-hydroxylase leads to greatly increased serum concentrations of 17-hydroxyprogesterone (17-OHP), while the absence of cortisol synthesis causes an increase in adrenocorticotrophic hormone. Moderately increased levels of 17-OHP may indicate an 11-beta-hydroxylase deficiency." ; rdfs:label "Elevated circulating 17-hydroxyprogesterone concentration" ; rdfs:subClassOf obo:HP_0031216 . obo:HP_0031214 dc:date "2017-07-02T11:29:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating dehydroepiandrosterone level" ; a owl:Class ; rdfs:comment "A reduced concentration of dehydroepiandrosterone in the blood. dehydroepiandrosterone is a weak androgen produced by the adrenal glands in both males and females." ; rdfs:label "Decreased circulating dehydroepiandrosterone concentration" ; rdfs:subClassOf obo:HP_0500022 . obo:HP_0031215 obo:IAO_0000115 "A reduced concentration of dehydroepiandrosterone-sulfate in the blood." ; dc:date "2017-07-02T11:31:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating dehydroepiandrosterone-sulfate level" ; a owl:Class ; rdfs:comment "DHEA is transformed into DHEA-S by sulfation at the C3beta position by sulfotransferase SULT2A1." ; rdfs:label "Decreased circulating dehydroepiandrosterone-sulfate concentration" ; rdfs:subClassOf obo:HP_0030347 . obo:HP_0031216 obo:IAO_0000115 "An elevated concentration of progesterone in the blood." ; dc:date "2017-07-02T11:33:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating progesterone" ; rdfs:subClassOf obo:HP_0031212 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17026 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031217 obo:IAO_0000115 "Sudden feelings of warmth that are generally most pronounced over the face, neck and chest." ; dc:date "2017-07-02T11:38:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hot flashes are most commonly due to menopause but may be observed with other conditions." ; rdfs:label "Hot flashes" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0031218 obo:IAO_0000115 "A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume." ; dc:date "2017-07-02T11:46:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inappropriate ADH secretion" ; oboInOwl:hasRelatedSynonym "SIADH", "Syndrome of inappropriate antidiuretic hormone secretion" ; a owl:Class ; rdfs:comment "Common etiologies of inappropriate antidiuretic hormone (ADH) secretion include nervous system disease, cancer, pulmonary disease, and as a side effect of a medication. This term is meant to refer to the inappropriately high level of ADH and not to the full syndrome of inappropriate antidiuretic hormone secretion (SIADH), which is considered a disease entity rather than a phenotypic feature." ; rdfs:label "Inappropriate antidiuretic hormone secretion" ; rdfs:subClassOf obo:HP_0031072 . obo:HP_0031219 obo:IAO_0000115 "A decreased amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker." ; dc:date "2017-07-02T11:55:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced radioactive iodine uptake" ; rdfs:subClassOf obo:HP_0031221 . obo:HP_0031220 obo:IAO_0000115 "An elevated amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker." ; dc:date "2017-07-02T11:59:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased radioactive iodine uptake" ; rdfs:subClassOf obo:HP_0031221 . obo:HP_0031221 obo:IAO_0000115 "Any deviation from normal in the amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker." ; dc:date "2017-07-02T12:00:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal radioactive iodine uptake test result" ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0031222 obo:IAO_0000115 "An elevated concentration of thyroxine-binding globulin (TBG) in the blood." ; dc:date "2017-07-02T12:03:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thyroxine-binding globulin high in blood" ; a owl:Class ; rdfs:comment "Thyroxine-binding globulin is one of the proteins that binds thyroid hormones in the circulation." ; rdfs:label "Increased circulating thyroxine-binding globulin level" ; rdfs:subClassOf obo:HP_0034590 . obo:HP_0031223 obo:IAO_0000115 "Hyperplasia of the islets of Langerhans that affects only certain regions of the pancreas and not others." ; dc:date "2017-07-02T12:06:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal pancreatic islet hyperplasia" ; rdfs:subClassOf obo:HP_0004510 . obo:HP_0031224 obo:IAO_0000115 "Hyperplasia of the islets of Langerhans with a generalized distribution." ; dc:date "2017-07-02T12:06:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diffuse pancreatic islet hyperplasia" ; rdfs:subClassOf obo:HP_0004510 . obo:HP_0031225 obo:IAO_0000115 "Blood flow through a region of the lung in which little or no ventilation takes place, resulting in reduced oxygenation of the blood leaving the lungs." ; dc:date "2017-07-02T12:12:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intrapulmonary shunting" ; a owl:Class ; rdfs:comment "Intrapulmonary shunt may be a result of blood flow through collapsed alveoli, tumors, arteriovenous pathways,and other conditions." ; rdfs:label "Intrapulmonary shunt" ; rdfs:subClassOf obo:HP_0030875 . obo:HP_0031226 obo:IAO_0000115 "An accumulation of fluid in one or more of the perinephric spaces, which consist of the subcapsular, perirenal, anterior and posterior pararenal spaces. This abnormality can be demonstrated by cross-sectional imaging, particularly computed tomography." ; dc:date "2017-07-02T12:16:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perinephric fluid collection" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0031227 obo:IAO_0000115 "A teratoma arising in the nasopharyngeal region." ; dc:date "2017-07-02T12:40:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Nasopharyngeal teratoma is histologically benign, but can cause considerable morbidity and mortality because of the location. Nasopharyngeal teratoma represents one of the most unusual causes of respiratory distress during the neonatal period." ; rdfs:label "Nasopharyngeal teratoma" ; rdfs:subClassOf obo:HP_0009792 . obo:HP_0031228 obo:IAO_0000115 "An abnormal shape of the incisura, defined as the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by the antitragus, and along its lower lateral margins and inferior boundary by the connection between the first two. The upper boundary is a somewhat arbitrary line crossing from the apices of the antitragus and the tragus." ; dc:date "2017-07-02T12:57:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal incisura morphology" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0031229 obo:IAO_0000115 "The length of the incisura from the upper to lower border is greater than that observed in the average population." ; dc:date "2017-07-02T12:58:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased incisura length" ; rdfs:subClassOf obo:HP_0031228 . obo:HP_0031230 obo:IAO_0000115 "The length of the incisura from the upper to lower border is less than that observed in the average population." ; dc:date "2017-07-02T13:00:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased incisura length" ; rdfs:subClassOf obo:HP_0031228 . obo:HP_0031231 obo:IAO_0000115 "Width of the incisura from the anterior to posterior border less than that observed in the average population." ; dc:date "2017-07-02T13:00:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Narrow incisura width" ; rdfs:subClassOf obo:HP_0031228 . obo:HP_0031232 obo:IAO_0000115 "Breadth of the incisura from the anterior to posterior border greater than that observed in the average population." ; dc:date "2017-07-02T13:02:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This aspect may be difficult to assess in instances where the anterior and posterior walls of the incisura are not parallel." ; rdfs:label "Increased incisura width" ; rdfs:subClassOf obo:HP_0031228 . obo:HP_0031233 obo:IAO_0000115 "A morphological abnormality of the scapula in which there is a flat (horizontal) inferior edge of the scapula. The entire scapula is said to resemble a square, leading to the designation sqaring of the scapula (in Figure 1 of PMID:24706940 the scapulae have a roughly rectangular shape)." ; dc:date "2017-07-02T13:23:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Squaring of the inferior scapulae", "Squaring of the scapula" ; a owl:Class ; rdfs:label "Horizontal inferior border of scapula" ; rdfs:subClassOf obo:HP_0000782 . obo:HP_0031234 obo:IAO_0000115 "A predominantly neutrophilic infiltrate of the dermis and or epidermis (i.e., a large number of neutrophils inferred to have migrated into the skin)." ; dc:date "2017-07-02T19:34:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neutrophilic infiltration of the skin" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0031235 obo:IAO_0000115 "Collection of neutrophils in the epidermis." ; dc:date "2017-07-02T19:36:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be seen in a variety of conditions ranging from inflammatory dermatosis like psoriasis, neonatal disorders e.g. transient neonatal pustular melanosis to neoplasms viz. keratoacanthoma." ; rdfs:label "Predominantly epidermal neutrophilic infiltrate" ; rdfs:subClassOf obo:HP_0031234 . obo:HP_0031236 obo:IAO_0000115 "Collection of neutrophils in the dermis." ; dc:date "2017-07-02T19:38:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Predominantly dermal neutrophilic infiltrate" ; rdfs:subClassOf obo:HP_0031234 . obo:HP_0031237 obo:IAO_0000115 "An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei." ; dc:date "2017-07-02T20:11:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Internally nucleated skeletal muscle fibres" ; a owl:Class ; rdfs:comment "A normal muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5 percent of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei." ; rdfs:label "Internally nucleated skeletal muscle fibers" ; rdfs:subClassOf obo:HP_0020201 . obo:HP_0031238 obo:IAO_0000115 "A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules." ; dc:date "2017-07-02T20:13:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Necklace skeletal muscle fibres" ; a owl:Class ; rdfs:label "Necklace skeletal muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0031239 obo:IAO_0000115 "A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 200 to 1500 micrometers from the center of the fovea." ; dc:date "2017-07-02T20:22:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extrafoveal choroidal neovascularization" ; rdfs:subClassOf obo:HP_0011506 . obo:HP_0031240 obo:IAO_0000115 "A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 1 to 199 micrometers from the center of the fovea." ; dc:date "2017-07-02T21:26:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Juxtafoveal choroidal neovascularization" ; rdfs:subClassOf obo:HP_0011506 . obo:HP_0031241 obo:IAO_0000115 "A type of choroidal neovascularization in which the area of neovascularization overlaps with the center of the fovea." ; dc:date "2017-07-02T21:27:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subfoveal choroidal neovascularization" ; rdfs:subClassOf obo:HP_0011506 . obo:HP_0031242 obo:IAO_0000115 "Reduced plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins." ; dc:date "2017-08-08T11:26:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating chylomicron levels", "Hypochylomicronemia" ; a owl:Class ; rdfs:label "Decreased circulating chylomicron concentration" ; rdfs:subClassOf obo:HP_0010981, obo:HP_0031887 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042627 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031243 obo:IAO_0000115 "A reduction in the amount of very-low-density lipoprotein cholesterol in the blood." ; dc:date "2017-08-08T11:27:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating very-low-density lipoprotein levels" ; a owl:Class ; rdfs:label "Decreased VLDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010981, obo:HP_0031889 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47773 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031244 obo:IAO_0000115 "Enlargement of the lip typically due to fluid buildup or inflammation." ; dc:date "2017-08-12T13:02:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Edematous lip", "Swelling of the lip" ; a owl:Class ; rdfs:label "Swollen lip" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0031245 obo:IAO_0000115 "A cough that produces phlegm or mucus." ; dc:date "2017-08-12T13:19:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cough with mucus production", "Wet cough" ; a owl:Class ; rdfs:label "Productive cough" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0031246 obo:IAO_0000115 "A cough that does not produce phlegm or mucus." ; dc:date "2017-08-12T13:19:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dry cough", "Dry coughing" ; a owl:Class ; rdfs:label "Nonproductive cough" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0031247 obo:IAO_0000115 "A type of cough characterized by a burst of numerous and rapid coughs followed by a long inhaling effort that is accompanied by a high-pitched whooping sound produced by the inhalation of air." ; dc:date "2017-08-12T13:22:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The term whooping cough is usually used to describe the disease caused by infection of the respiratory tract with Bordatella pertussis. This HPO term refers to the major symptom of that disease." ; rdfs:label "Whooping cough" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0031248 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand." ; dc:date "2017-08-12T13:33:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Itchy palm" ; a owl:Class ; rdfs:label "Palmar pruritus" ; rdfs:subClassOf obo:HP_0030899 . obo:HP_0031249 obo:IAO_0000115 "A distortion of the sense of taste, often characterized by the sensation of a metallic taste." ; dc:date "2017-08-12T13:35:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Altered sense of taste", "Dysgeusia", "Metallic taste", "Metallic taste in mouth" ; a owl:Class ; rdfs:label "Parageusia" ; rdfs:subClassOf obo:HP_0000223 . obo:HP_0031250 obo:IAO_0000115 "A severe crack in a lip. A lip fissure may be painful, may bleed and often is a recurring manifestation." ; dc:date "2017-08-12T15:27:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lip fissure" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0031251 obo:IAO_0000115 "Any anomaly of a subclavian artery." ; dc:date "2017-08-12T15:35:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The left and right subclavian arteries supply blood to the posterior cerebral circulation, cerebellum, posterior neck, upper limbs and the superior and anterior chest wall. The right subclavian artery is a terminal branch of the brachiocephalic artery,and the left subclavian artery is the third branch of the aortic arch (following the left common carotid artery)." ; rdfs:label "Abnormal subclavian artery morphology" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0031252 obo:IAO_0000115 "Abnormally increased caliber of the left subclavian artery." ; dc:date "2017-08-12T15:38:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dilated left subclavian artery" ; rdfs:subClassOf obo:HP_0031251 . obo:HP_0031253 obo:IAO_0000115 "Origin of the left subclavian artery from an anomalous anatomical location." ; dc:date "2017-08-12T15:41:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of left subclavian artery" ; rdfs:subClassOf obo:HP_0031251 . obo:HP_0031254 obo:IAO_0000115 "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the thalamus." ; dc:date "2017-08-12T15:44:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thalamic arteriovenous malformation" ; rdfs:subClassOf obo:HP_0010663 . obo:HP_0031255 obo:IAO_0000115 "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the hypothalamus." ; dc:date "2017-08-12T15:49:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypothalamic arteriovenous malformation" ; rdfs:subClassOf obo:HP_0012286 . obo:HP_0031256 obo:IAO_0000115 "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the optic nerve." ; dc:date "2017-08-12T15:51:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Optic nerve arteriovenous malformation" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0031257 obo:IAO_0000115 "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the maxilla." ; dc:date "2017-08-12T15:53:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This abnormality may be accompanied by gingival swelling adjacent to the affected maxilla as well as by loosening of nearby teeth. Radiographic examination mayreveal a lytic lesion of the maxilla." ; rdfs:label "Arteriovenous malformation of the maxilla" ; rdfs:subClassOf obo:HP_0000326 . obo:HP_0031258 obo:IAO_0000115 "A state of sudden and severe confusion." ; dc:date "2017-08-12T16:00:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delirium" ; rdfs:subClassOf obo:HP_0001289 . obo:HP_0031259 obo:IAO_0000115 "An inflammation of the ovary or ovaries." ; dc:date "2017-08-12T16:02:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inflammed ovary" ; a owl:Class ; rdfs:label "Oophoritis" ; rdfs:subClassOf obo:HP_0031065 . obo:HP_0031260 obo:IAO_0000115 "A short, dysplastic tibia with a triangular shape. Instead of the normal shaft configuration of the tibia, the tibia forms a triangle with the longest side corresponding to the proximal-distal dimension, and the apex of the triangle directed laterally." ; dc:date "2017-08-12T16:09:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triangular tibia" ; rdfs:subClassOf obo:HP_0002992 . obo:HP_0031261 obo:IAO_0000115 "An abnormal growth that projects from the mucous membrane of the urinary bladder." ; dc:date "2017-08-12T16:13:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bladder polyp" ; rdfs:subClassOf obo:HP_0025487 . obo:HP_0031263 obo:IAO_0000115 "Any anomolous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule." ; dc:date "2017-08-12T18:30:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal corpuscle morphology" ; rdfs:subClassOf obo:HP_0011035, obo:HP_0012575 . obo:HP_0031264 obo:IAO_0000115 "A structural anomaly of the double-walled capsule (Bowman capsule) that opens into a renal tubule." ; dc:date "2017-08-12T18:34:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal morphology of Bowman capsule", "Abnormal morphology of Bowman's capsule", "Abnormal renal glomerular capsule morphology" ; a owl:Class ; rdfs:label "Abnormal Bowman capsule morphology" ; rdfs:subClassOf obo:HP_0031263 . obo:HP_0031265 obo:IAO_0000115 "Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary." ; dc:date "2017-08-12T18:36:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal podocyte morphology", "Abnormal visceral epithelial cell morphology" ; a owl:Class ; rdfs:comment "Podocytes (or visceral epithelial cells) are terminally differentiated cells lining the outer surface of the glomerular capillaries. As a major component of the ultrafiltration apparatus, podocytes have a complex cellular architecture consisting of cell body, major processes that extend outward from their cell body, forming interdigitated foot processes that enwrap the glomerular capillaries." ; rdfs:label "Abnormal glomerular visceral epithelial cell morphology" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0031266 obo:IAO_0000115 "An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier." ; dc:date "2017-08-12T19:38:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Loss of primary podocyte processes" ; a owl:Class ; rdfs:comment "Two stages of podocyte foot process effacement (FPE) may clearly be distinguished. Within the first stage, foot processes undergo tremendous changes in shape, losing their regular interdigitating pattern and retracting into short irregularly shaped cell projections. Slit diaphragms are lost or displaced from their usual position at the base and replaced by occludens-type junctions between the deformed, broadened foot processes. These changes are necessarily associated with considerable movements of these processes in relation to the glomerular basemenet membrane (GBM). The second phase, the completed stage of FPE, includes retraction of the foot processes into the primary podocyte cell processes, leading to broad flattened disc-like projections that cover the GBM, finally merging with the cell bodies. At this point, the cell bodies have lost their usual position floating above the GBM within the filtrate in Bowman space. Instead they broadly adhere directly to the GBM. The subpodocyte space beneath the podocyte cell body has largely disappeared in this stage." ; rdfs:label "Podocyte foot process effacement" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0031267 obo:IAO_0000115 "Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus." ; dc:date "2017-08-12T19:45:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be measured by flow cytometry." ; rdfs:label "Abnormal CD69 upregulation upon TCR activation" ; rdfs:subClassOf obo:HP_0410035 . obo:HP_0031268 obo:IAO_0000115 "Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR)." ; dc:date "2017-08-12T19:50:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased CD69 upregulation upon TCR activation" ; rdfs:subClassOf obo:HP_0031267 . obo:HP_0031269 obo:IAO_0000115 "Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression." ; dc:date "2017-08-12T19:51:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal CD25 upregulation upon TCR activation" ; rdfs:subClassOf obo:HP_0410035 . obo:HP_0031270 obo:IAO_0000115 "Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR)." ; dc:date "2017-08-12T20:02:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Poor CD25 upregulation upon TCR activation", "Reduced IL2RA upregulation upon TCR activation" ; a owl:Class ; rdfs:label "Decreased CD25 upregulation upon TCR activation" ; rdfs:subClassOf obo:HP_0031269 . obo:HP_0031271 obo:IAO_0000115 "The pulsation of the posterior tibial artery behind the internal malleolus, or of the dorsalis pedis artery, cannot be detected on physical examination." ; dc:date "2017-08-12T20:39:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "While examining the pulse, the observer should note its intensity, rate, rhythm, and if any blood vessel tenderness, tortuosity, or nodularity exists." ; rdfs:label "Absent ankle pulse" ; rdfs:subClassOf obo:HP_0032554 . obo:HP_0031272 obo:IAO_0000115 "Accumulation of lipids and inflammatory cells along the inner walls of the pulmonary artery." ; dc:date "2017-08-12T20:44:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pulmonary artery atherosclerosis is less common than systemic arterial atherosclerosis." ; rdfs:label "Pulmonary arterial atherosclerosis" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0031273 obo:IAO_0000115 "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury." ; dc:date "2017-08-12T20:50:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Shock" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0031274 obo:IAO_0000115 "A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures." ; dc:date "2017-08-12T20:57:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypovolemic shock" ; rdfs:subClassOf obo:HP_0031273 . obo:HP_0031275 obo:IAO_0000115 "A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage" ; dc:date "2017-08-12T20:59:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Distribute shock is caused by inadequate cardiac preload due to vasodilatation and vascular leakage. Etiologies include postoperative SIRS, sepsis, anaphylactic reaction." ; rdfs:label "Distributive shock" ; rdfs:subClassOf obo:HP_0031273 . obo:HP_0031276 obo:IAO_0000115 "A type of shock characterized by inadequate cardiac preload due to obstructed venous return (e.g. pericardial tamponade, tension pneumothorax, abdominal compartment) or obstruction of arterial blood flow (e.g. pulmonary embolism)." ; dc:date "2017-08-12T21:01:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Obstructive shock" ; rdfs:subClassOf obo:HP_0031273 . obo:HP_0031278 obo:IAO_0000115 "Any structural anomaly of the thoracic duct." ; dc:date "2017-08-13T16:33:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal thoracic duct morphology" ; rdfs:subClassOf obo:HP_0100766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031279 obo:IAO_0000115 "An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." ; dc:date "2017-08-13T16:47:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal response to GnRH stimulation test" ; a owl:Class ; rdfs:comment "This test is regarded as the gold standard to identify central precocious puberty." ; rdfs:label "Abnormal response to gonadotropin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0031073 . obo:HP_0031280 obo:IAO_0000115 "An abnormally high amount of luteinizing hormone (LH) is released upon gonadotropin-releasing hormone stimulation test." ; dc:date "2017-08-13T16:52:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased LH response to gonadotropin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0031279 . obo:HP_0031281 obo:IAO_0000115 "Inflammation of a salivary gland." ; dc:date "2017-08-13T17:06:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sialadenitis" ; rdfs:subClassOf obo:HP_0010286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_212 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001044 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031282 obo:IAO_0000115 "A lateral deviation of the nail plate of the great toe along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges." ; dc:date "2017-08-13T17:08:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:27171597." ; rdfs:label "Malalignment of the great toenail" ; rdfs:subClassOf obo:HP_0008388 . obo:HP_0031283 obo:IAO_0000115 "The presence of tufts of 8-15 hairs that appear to emerge from a single follicular orifice." ; dc:date "2017-08-13T17:39:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tufted hairs" ; rdfs:subClassOf obo:HP_0011360 . obo:HP_0031284 obo:IAO_0000115 "Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin." ; dc:date "2017-08-13T20:14:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Flushing can occur on the face, neck and, less frequently, the upper trunk and abdomen." ; rdfs:label "Flushing" ; rdfs:subClassOf obo:HP_0011354 . obo:HP_0031285 obo:IAO_0000115 "Any structural anomaly in the areas surrounding the hair follicles." ; dc:date "2017-08-13T20:25:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal perifollicular morphology" ; rdfs:subClassOf obo:HP_0000951 . obo:HP_0031286 obo:IAO_0000115 "Redness surrounding the hair follicles." ; dc:date "2017-08-13T20:27:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perifollicular erythema" ; rdfs:subClassOf obo:HP_0031285 . obo:HP_0031287 obo:IAO_0000115 "A raised growth on the skin of older individuals. The lesion usually is initially light tan and may darken to dark brown or nearly black. The consistent feature of seborrheic keratoses is their waxy, pasted-on or stuck-on look." ; dc:date "2017-08-13T20:33:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basal cell papilloma", "Seborrheic verruca", "Senile wart" ; a owl:Class ; rdfs:comment "Seborrheic keratosis is a benign lesion of the skin that occurs more frequently in sunlight exposed areas. The lesions can appear anywhere on the body, but most often occur on the face, chest, and back. There may be just one or clusters of dozens." ; rdfs:label "Seborrheic keratosis" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0031288 obo:IAO_0000115 "The presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones." ; dc:date "2017-08-13T20:43:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cobblestone-like hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0031289 obo:IAO_0000115 "A papule with white color." ; dc:date "2017-08-13T20:48:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "White papule" ; rdfs:subClassOf obo:HP_0200034 . obo:HP_0031290 obo:IAO_0000115 "A type of xanthoma characterized by a nodular form. Tuberous xanthomas are firm subcutaneous nodules,whereby the overlying skin can have red or red-yellow color changes." ; dc:date "2017-08-13T21:03:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tuberous xanthoma" ; rdfs:subClassOf obo:HP_0000991 . obo:HP_0031291 obo:IAO_0000115 "Ichthyosis follicularis is characterized by widespread non inflammatory thorn-like follicular projections. Dyskeratotic papules are most pronounced over the extensor extremities and scalp and are symmetrically distributed." ; dc:date "2017-08-13T21:18:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ichthyosis follicularis" ; rdfs:subClassOf obo:HP_0008064 . obo:HP_0031292 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the skin." ; dc:date "2017-08-13T21:21:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin abscess" ; a owl:Class ; rdfs:label "Cutaneous abscess" ; rdfs:subClassOf obo:HP_0011123, obo:HP_0025615 . obo:HP_0031293 obo:IAO_0000115 "Pinhole-sized concave depressions with hyperkeratosis in the skin of a finger or toe." ; dc:date "2017-08-13T21:25:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Digital pitting scar" ; rdfs:subClassOf obo:HP_0100276 . obo:HP_0031294 obo:IAO_0000115 "Underdeveloped, small right heart atrium." ; dc:date "2017-08-13T21:36:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypoplastic right atrium" ; rdfs:subClassOf obo:HP_0025580 . obo:HP_0031295 obo:IAO_0000115 "Increase in size of the left atrium." ; dc:date "2017-08-13T21:38:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:3011", "Fyler:3020" ; oboInOwl:hasExactSynonym "Enlarged heart left atrium" ; a owl:Class ; rdfs:label "Left atrial enlargement" ; rdfs:subClassOf obo:HP_0025579 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031296 obo:IAO_0000115 "An abnormal increase in the thickness of the atrial septum." ; dc:date "2017-08-13T21:41:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atrial septal hypertrophy" ; rdfs:subClassOf obo:HP_0005120 . obo:HP_0031297 obo:IAO_0000115 "Unroofed coronary sinus (CS) is a rare congenital cardiac anomaly in which there is partial (either focal or fenestrated) or complete absence of the roof of the CS, which results in a communication between the CS and the LA. Unroofed CS is the rarest type of atrial septal defect. It is often associated with persistent left superior vena cava (LSVC) and other forms of complex congenital heart disease, usually heterotaxia syndromes. The morphological types have been classified into 4 groups: Type I, completely unroofed with persistent LSVC; type II, completely unroofed without persistent LSVC; type III, partially unroofed mid portion; and type IV, partially unroofed terminal portion." ; dc:date "2017-08-13T21:44:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unroofed coronary sinus" ; rdfs:subClassOf obo:HP_0001631, obo:HP_0011642 . obo:HP_0031298 obo:IAO_0000115 "Abnormal increase in size of the coronary sinus." ; dc:date "2017-08-13T21:47:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coronary sinus dilatation", "Enlarged coronary sinus" ; a owl:Class ; rdfs:comment "The coronary sinus is rarely seen on echocardiography in healthy persons. The differential diagnosis of dilated coronary sinus includes right ventricular dysfunction, right atrial hypertension, and anomalous venous drainage into the coronary sinus." ; rdfs:label "Coronary sinus enlargement" ; rdfs:subClassOf obo:HP_0011642 . obo:HP_0031299 obo:IAO_0000115 "An abnormal increase in magnitude of the pressure in the left atrium." ; dc:date "2017-08-13T21:54:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated left atrial pressure" ; rdfs:subClassOf obo:HP_0025443 . obo:HP_0031300 obo:IAO_0000115 "A deviation from the normal concentration of properdin in the blood." ; dc:date "2017-08-13T22:01:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are three pathways of complement activation, the classical pathway, lectin pathway, and alternative pathway. Each generates a C3 convertase, a serine protease that cleaves the central complement protein, C3. Nearly all the biological consequences of complement are dependent on the resulting cleavage products. Properdin is a positive regulator of complement activation that stabilizes the alternative pathway convertases (C3bBb). Properdin is composed of multiple identical protein subunits, with each subunit carrying a separate ligand-binding site." ; rdfs:label "Abnormal circulating properdin level" ; rdfs:subClassOf obo:HP_0025465 . obo:HP_0031301 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall." ; dc:date "2017-08-26T20:56:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peripheral artery calcification" ; a owl:Class ; rdfs:comment "Peripheral arterial calcification can be observed on radiographs and may be classified as either medial (linear calcifications in a train-track pattern) or atherosclerotic (distinct, nodular calcifications). A number of other techniques may also be used to detect peripheral arterial calcification including computed tomographic (CT) and magnetic resonance (MR) imaging, duplex ultrasonography, measurement of pulse wave velocity, echocardiography, planar radiographs, and indirectly, the ankle-brachial index. A discussion on the ontological description of peripheral arterial calcification can be found here: https://github.com/obophenotype/human-phenotype-ontology/issues/6877." ; rdfs:label "Peripheral arterial calcification" ; rdfs:subClassOf obo:HP_0003207 . obo:HP_0031302 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the leg." ; dc:date "2017-08-26T21:03:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lower extremity peripheral artery calcification" ; a owl:Class ; rdfs:comment "GitHub issue: https://github.com/obophenotype/human-phenotype-ontology/issues/6877" ; rdfs:label "Lower extremity peripheral arterial calcification" ; rdfs:subClassOf obo:HP_0031301 . obo:HP_0031303 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the femoral artery." ; dc:date "2017-08-26T21:04:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Femoral arterial calcification" ; rdfs:subClassOf obo:HP_0031302, obo:HP_0035012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002060 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031304 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the iliac artery." ; dc:date "2017-08-26T21:05:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Iliac arterial calcification" ; rdfs:subClassOf obo:HP_0031302, obo:HP_4000066 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031305 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the tibial artery." ; dc:date "2017-08-26T21:05:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tibial arterial calcification" ; rdfs:subClassOf obo:HP_0031302 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007610 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031306 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in an artery that is located within the skull (intracranial)." ; dc:date "2017-08-26T21:30:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intracranial arterial calcification" ; rdfs:subClassOf obo:HP_0003207 . obo:HP_0031307 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the internal carotid artery." ; dc:date "2017-08-26T21:32:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Internal carotid artery calcification" ; rdfs:subClassOf obo:HP_0031306, obo:HP_0031314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001532 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031308 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the vertebral artery." ; dc:date "2017-08-26T21:33:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vertebral artery calcification" ; rdfs:subClassOf obo:HP_0030321, obo:HP_0031306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001535 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031309 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a cerebral artery." ; dc:date "2017-08-26T21:34:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cerebral artery calcification" ; rdfs:subClassOf obo:HP_0031306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031310 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the basilar artery." ; dc:date "2017-08-26T21:35:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Basilar artery calcification" ; rdfs:subClassOf obo:HP_0031306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031311 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the middle cerebral artery." ; dc:date "2017-08-26T21:36:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Middle cerebral artery calcification" ; rdfs:subClassOf obo:HP_0031309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001627 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031313 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in abdominal aorta." ; dc:date "2017-08-26T21:44:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abdominal aortic calcification" ; rdfs:subClassOf obo:HP_0004963 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001516 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031314 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a carotid artery." ; dc:date "2017-08-26T21:52:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Carotid artery calcification" ; rdfs:subClassOf obo:HP_0003207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031315 obo:IAO_0000115 "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the external carotid artery." ; dc:date "2017-08-26T21:53:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "External carotid artery calcification" ; rdfs:subClassOf obo:HP_0031314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001070 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031316 obo:IAO_0000115 "A structural anomaly of the muscle layer of the heart wall of a cardiac ventricle." ; dc:date "2017-08-27T11:43:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ventricular myocardium morphology" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0031317 obo:IAO_0000115 "Presence of an increased amount of fat tissue within a cardiac ventricle with corresponding reduction of muscle tissue." ; dc:date "2017-08-27T11:45:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fatty infiltration of cardiac ventricle", "Intramyocardial fat infiltration" ; a owl:Class ; rdfs:label "Fatty replacement of ventricular myocardial tissue" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0031318 obo:IAO_0000115 "A nonparallel arrangement of cardiac myocytes." ; dc:date "2017-08-27T11:50:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myocardial fiber disarray", "Myocardial fibre disarray" ; a owl:Class ; rdfs:comment "The presence of a sufficient quantity of myocardial fibers showing this change is considered to be a specific histological feature of hypertrophic cardiomyopathy." ; rdfs:label "Myofiber disarray" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0031319 obo:IAO_0000115 "An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes." ; dc:date "2017-08-27T11:58:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myocyte cellular hypertrophy" ; a owl:Class ; rdfs:comment "Adult cardiac myocytes are highly specialized, terminally differentiated cells which have lost the ability to divide. The increase in heart muscle mass seen in cardiac hypertrophy occurs predominantly through an increase in myocyte size rather than number. Hypertrophy is the principal response of the heart to overload from any cause, including hypertension, myocardial infarction, valvar heart disease, and dilated cardiomyopathy." ; rdfs:label "Cardiomyocyte hypertrophy" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031320 obo:IAO_0000115 "An abnormal increase in the number of mitochondria per cardiac myocyte." ; dc:date "2017-08-27T12:02:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiomyocyte mitochondrial proliferation" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031321 obo:IAO_0000115 "An increase in the number of immune cells in myocardial tissue (which can be assumed to have migrated into the myocardium)." ; dc:date "2017-08-27T12:06:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myocardial immune cell infiltration" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0031322 obo:IAO_0000115 "An increase in the number of lymphocytes in myocardial tissue." ; dc:date "2017-08-27T12:08:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myocardial lymphocytic infiltration" ; rdfs:subClassOf obo:HP_0031321 . obo:HP_0031323 obo:IAO_0000115 "An increase in the number of eosinophils in myocardial tissue." ; dc:date "2017-08-27T12:08:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myocardial eosinophilic infiltration" ; rdfs:subClassOf obo:HP_0031321 . obo:HP_0031324 obo:IAO_0000115 "The presence of extremely large cells with multiple nuclei. The so-called giant cells are thought to be of macrophage origin." ; dc:date "2017-08-27T12:15:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myocardial multinucleated giant cells" ; rdfs:subClassOf obo:HP_0031321 . obo:HP_0031325 obo:IAO_0000115 "The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the myocardium." ; dc:date "2017-08-27T12:21:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myocardial granulomatous infiltrates" ; rdfs:subClassOf obo:HP_0031321 . obo:HP_0031326 obo:IAO_0000115 "A type of cardiac amyloidosis related to deposition of an immunoglobulin light chain. The current gold standard of amyloid typing is to determine the precursor protein using laser microdissection mass spectrometry." ; dc:date "2017-08-27T12:23:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal light chain cardiac amyloidosis" ; rdfs:subClassOf obo:HP_0030843 . obo:HP_0031327 obo:IAO_0000115 "A type of cardiac amyloidosis related to deposition of transthyretin (TTR), which is identified by immunohistochemical staining." ; dc:date "2017-08-27T12:29:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "TTR cardiac amyloidosis" ; a owl:Class ; rdfs:label "Transthyretin cardiac amyloidosis" ; rdfs:subClassOf obo:HP_0030843 . obo:HP_0031328 obo:IAO_0000115 "A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in perivascular spaces." ; dc:date "2017-08-27T12:38:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perivascular cardiac fibrosis" ; rdfs:subClassOf obo:HP_0001685, obo:HP_0032200 . obo:HP_0031329 obo:IAO_0000115 "A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in interstitial spaces." ; dc:date "2017-08-27T12:39:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interstitial cardiac fibrosis" ; rdfs:subClassOf obo:HP_0001685 . obo:HP_0031330 obo:IAO_0000115 "An increase in the number of immune cells in myocardial tissue concentrated in the spaces surrounding blood vessels." ; dc:date "2017-08-27T12:41:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perivascular myocardial immune cell infiltration" ; rdfs:subClassOf obo:HP_0031321 . obo:HP_0031331 obo:IAO_0000115 "Any structural anomaly of cardiomyocytes, which are terminally differentiated muscle cells in the heart that are interconnected end to end by gap junctions, which allows coordinated contraction of heart tissue." ; dc:date "2017-08-27T12:50:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cardiac muscle cell morphology" ; a owl:Class ; rdfs:label "Abnormal cardiomyocyte morphology" ; rdfs:subClassOf obo:HP_0001627, obo:HP_0025461 . obo:HP_0031332 obo:IAO_0000115 "Deterioration of cardiomyocyte characterized by abnormal features such as loss of myofilaments, occurrence of cellular sequestration, decreased mitochondrial sizes and cellular debris." ; dc:date "2017-08-27T12:54:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiomyocyte degeneration" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031333 obo:IAO_0000115 "A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes." ; dc:date "2017-08-27T13:11:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cardiac biopsy: myocyte disarray", "Cardiomyocyte disarray", "Myocardial sarcomere disarray" ; a owl:Class ; rdfs:label "Myocardial sarcomeric disarray" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031334 obo:IAO_0000115 "Nuclear or cytoplasmic aggregates of stainable substances within cardiomyocytes." ; dc:date "2017-08-27T13:18:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiomyocyte inclusion bodies" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031335 obo:IAO_0000115 "An anomaly of the structure of mitochondria within cardiomyocytes." ; dc:date "2017-08-27T13:21:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiomyocyte mitochondrial morphology" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031336 obo:IAO_0000115 "Abnormal localization of mitochondria within the nuclei of cardiomyocytes." ; dc:date "2017-08-27T13:30:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Electron microscopy of mammalian cardiac and skeletal muscle tissues reveal mitochondria as individual organelles situated either in clusters beneath the sarcolemma (subsarcolemmal mitochondria) or in longitudinal rows within the contractile apparatus (interfibrillar mitochondria)." ; rdfs:label "Intranuclear cardiomyocyte mitochondria" ; rdfs:subClassOf obo:HP_0031335 . obo:HP_0031337 obo:IAO_0000115 "Anomalous staining of Connexin43 in cardiomyocytes. Connexin43 (Cx43) is the primary gap junction protein in the working myocardium. Cx43 exhibits increased localization at the lateral membranes of cardiomyocytes in a variety of heart diseases." ; dc:date "2017-08-27T13:35:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiomyocyte connexin43 staining" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031338 obo:IAO_0000115 "Anomalous staining of plakoglobin in cardiomyocytes. Plakoglobin is a component of desmosomes in cardiomyocytes." ; dc:date "2017-08-27T13:39:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiomyocyte plakoglobin staining" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031339 obo:IAO_0000115 "Anomalous staining of dystrophin in cardiomyocytes." ; dc:date "2017-08-27T13:42:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Dystrophin, a 427-kD cytoskeletal protein, is a member of the beta-spectrin/alpha-actinin protein family. Dystrophin and the dystrophin-associated proteins (dystroglycans, sarcoglycans, sarcospan, dystrobrevin, and syntrophins) form a complex that is involved in contractile force transmission and stabilization of the plasma membrane." ; rdfs:label "Abnormal cardiomyocyte dystrophin staining" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0031340 obo:IAO_0000115 "A structural anomaly of lysosomes, membrane-enclosed organelles that contain an array of enzymes capable of catabolizing proteins, nucleic acids, carbohydrates, and lipids." ; dc:date "2017-08-27T13:46:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lysosomal morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0031341 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the stomach." ; dc:date "2017-08-27T13:53:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gastric arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002629 . obo:HP_0031342 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the duodenum." ; dc:date "2017-08-27T13:55:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Duodenal arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002629 . obo:HP_0031343 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the jejunum." ; dc:date "2017-08-27T13:55:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Jejunal arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002629 . obo:HP_0031344 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the pelvis." ; dc:date "2017-08-27T13:56:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pelvic arteriovenous malformation" ; rdfs:subClassOf obo:HP_0100026 . obo:HP_0031345 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the colon." ; dc:date "2017-08-27T13:57:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Colonic arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002629 . obo:HP_0031346 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the rectum." ; dc:date "2017-08-27T13:59:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rectal arteriovenous malformation" ; rdfs:subClassOf obo:HP_0002629 . obo:HP_0031347 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the uterus." ; dc:date "2017-08-27T13:59:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine arteriovenous malformation" ; rdfs:subClassOf obo:HP_0100026 . obo:HP_0031348 obo:IAO_0000115 "A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the right of the pulmonary artery. This is the most common kind of TGA." ; dc:date "2017-08-27T14:17:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:0700", "Fyler:700" ; oboInOwl:hasExactSynonym "D-TGA", "D-loop transposition of the great arteries" ; a owl:Class ; rdfs:label "Dextrotransposition of the great arteries" ; rdfs:subClassOf obo:HP_0001669 . obo:HP_0031349 obo:IAO_0000115 "A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the left of the pulmonary artery." ; dc:date "2017-08-27T14:19:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "L-TGA" ; a owl:Class ; rdfs:label "Levotransposition of the great arteries" ; rdfs:subClassOf obo:HP_0001669 . obo:HP_0031350 obo:IAO_0000115 "A malignant soft tissue neoplasm that arises from the heart." ; dc:date "2017-08-27T14:27:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiac sarcoma" ; rdfs:subClassOf obo:HP_0100544 . obo:HP_0031351 obo:IAO_0000115 "A non-neoplastic cardiac tumor characterized by calcification and eosinophilic amorphous material in the background of dense collagenous fibrous tissue." ; dc:date "2017-08-27T14:28:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Calcified amorphous tumour of the heart" ; a owl:Class ; rdfs:label "Calcified amorphous tumor of the heart" ; rdfs:subClassOf obo:HP_0100544 . obo:HP_0031352 obo:IAO_0000115 "An unpleasant sensation of tightness or pressure in the chest." ; dc:date "2017-08-27T14:49:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tightness in chest", "Tightness of chest" ; oboInOwl:hasRelatedSynonym "Chest distress" ; a owl:Class ; rdfs:label "Chest tightness" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0031353 obo:IAO_0000115 "Otitis media characterized by thick or sticky fluid behind the tympanic membrane." ; dc:date "2017-08-27T14:53:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fluid behind eardrum" ; a owl:Class ; rdfs:label "Otitis media with effusion" ; rdfs:subClassOf obo:HP_0000388 . obo:HP_0031354 obo:IAO_0000115 "Difficulty initiating sleep, that is, increased sleep onset latency." ; dc:date "2017-08-27T15:00:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Difficulty falling asleep" ; a owl:Class ; rdfs:label "Sleep onset insomnia" ; rdfs:subClassOf obo:HP_0100785 . obo:HP_0031355 obo:IAO_0000115 "Abnormal difficulty in staying asleep. Affected individuals tend to wake up at night and have difficulty returning to sleep." ; dc:date "2017-08-27T15:04:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Waking up several times during the night" ; a owl:Class ; rdfs:label "Maintenance insomnia" ; rdfs:subClassOf obo:HP_0100785 . obo:HP_0031356 obo:IAO_0000115 "A type of insomnia characterized by waking up (too) early in the morning." ; dc:date "2017-08-27T15:04:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Late insomnia" ; a owl:Class ; rdfs:label "Terminal insomnia" ; rdfs:subClassOf obo:HP_0100785 . obo:HP_0031357 obo:IAO_0000115 "A histologically distinctive, cutaneous, benign vascular tumor that is characterized by a solitary or multiple blue-red papules and histologically resembles renal glomeruli." ; dc:date "2017-08-27T15:44:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomeruloid hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0031358 obo:IAO_0000115 "Absence of wakefulness and conscience, but (in contrast to coma) with involuntary opening of the eyes and movements (such as teeth grinding, yawning, or thrashing of the extremities)." ; dc:date "2017-08-27T15:49:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vegetative state" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0031359 obo:IAO_0000115 "A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter that is characterized by hardening (sclerosis) of the affected skin area (related to collagen thickening)." ; dc:date "2017-08-27T15:54:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cutaneous sclerotic plaque" ; rdfs:subClassOf obo:HP_0200035 . obo:HP_0031360 obo:IAO_0000115 "A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter and that has a yellow color." ; dc:date "2017-08-27T15:56:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Yellow skin plaque" ; rdfs:subClassOf obo:HP_0200035 . obo:HP_0031361 obo:IAO_0000115 "Intralysosomal, osmiophilic, lamellated and sometimes concentric cytoplasmic inclusions comprised of broad transversely-stacked myelinoid membranes and said to resemble a zebra in electron microscopic images." ; dc:date "2017-08-27T16:00:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Zebra bodies" ; rdfs:subClassOf obo:HP_0031340 . obo:HP_0031362 obo:IAO_0100001 "HP:0000007" ; dc:date "2017-08-29T11:43:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Sex-limited autosomal recessive inheritance" ; owl:deprecated true . obo:HP_0031363 obo:IAO_0000115 "A type of purpura in which the lesions are raised (and can therefore be appreciated upon palpation)." ; dc:date "2017-08-29T12:31:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palpable purpura" ; rdfs:subClassOf obo:HP_0000979 . obo:HP_0031364 obo:IAO_0000115 "A purpuric lesion that is larger than 1 cm in diameter." ; dc:date "2017-08-29T12:32:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ecchymoses" ; a owl:Class ; rdfs:label "Ecchymosis" ; rdfs:subClassOf obo:HP_0031365 . obo:HP_0031365 obo:IAO_0000115 "Purpura that is flat (non-palpable, not raised)." ; dc:date "2017-08-29T12:35:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flat purpura" ; a owl:Class ; rdfs:label "Macular purpura" ; rdfs:subClassOf obo:HP_0000979 . obo:HP_0031366 obo:IAO_0000115 "A neoplasm that affects the hard palate, soft palate, or uvula." ; dc:date "2017-09-02T00:52:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palate neoplasm" ; rdfs:subClassOf obo:HP_0100649 . obo:HP_0031367 obo:IAO_0000115 "Longitudinal densities on radiographs located in a metaphysis (the narrow region of a long bone between the epiphysis and the diaphysis)." ; dc:date "2017-09-02T01:05:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Striated metaphysis" ; a owl:Class ; rdfs:label "Metaphyseal striations" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0031368 obo:IAO_0000115 "A hole (perforation) in the wall of the intestine." ; dc:date "2017-09-02T01:23:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intestinal perforation" ; rdfs:subClassOf obo:HP_0002242 . obo:HP_0031369 obo:IAO_0000115 "A hole (perforation) in the wall of the colon." ; dc:date "2017-09-02T01:29:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Perforation of the colon" ; a owl:Class ; rdfs:label "Colon perforation" ; rdfs:subClassOf obo:HP_0031368 . obo:HP_0031370 obo:IAO_0000115 "A hole (perforation) in the wall of the small intestine." ; dc:date "2017-09-02T01:30:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small intestinal perforation" ; rdfs:subClassOf obo:HP_0031368 . obo:HP_0031371 obo:IAO_0000115 "A hole (perforation) in the wall of the rectum." ; dc:date "2017-09-02T01:31:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rectal perforation" ; rdfs:subClassOf obo:HP_0031368 . obo:HP_0031372 obo:IAO_0000115 "Increased muscle weakness upon exposure to cold temperatures." ; dc:date "2017-09-02T01:39:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cold paresis" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0031373 obo:IAO_0000115 "Increased rigidity and reduced mobility of the tongue." ; dc:date "2017-09-02T01:42:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tongue stiffness" ; a owl:Class ; rdfs:label "Stiff tongue" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0031374 obo:IAO_0000115 "Reduced strength of the muscles that lift or otherwise move the foot at the ankle." ; dc:date "2017-09-02T01:47:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ankle weakness" ; rdfs:subClassOf obo:HP_0001324 . obo:HP_0031375 obo:IAO_0000115 "Applies to a sign or symptom that is difficult to treat or cure." ; dc:date "2017-09-02T01:54:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Refractory" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0031377 obo:IAO_0000115 "Any abnormality in the multiplication or reproduction of cells, which may result in the expansion of a cell population." ; dc:date "2017-09-02T15:54:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cell proliferation" ; rdfs:subClassOf obo:HP_0011017 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0008283 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031378 obo:IAO_0000115 "Any abnormality in the multiplication or reproduction of lymphocytes, which results in the expansion of a cell population." ; dc:date "2017-09-02T15:55:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lymphocyte proliferation" ; rdfs:subClassOf obo:HP_0031377, obo:HP_0031409 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046651 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031379 obo:IAO_0000115 "Any abnormality in the multiplication or reproduction of T cells, which results in the expansion of a cell population." ; dc:date "2017-09-02T15:56:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal T cell proliferation" ; rdfs:subClassOf obo:HP_0011840, obo:HP_0031378 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042098 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031380 obo:IAO_0000115 "Any abnormality in the multiplication or reproduction of B cells, which results in the expansion of a cell population." ; dc:date "2017-09-02T15:56:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal B cell proliferation" ; rdfs:subClassOf obo:HP_0031378 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042100 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031381 obo:IAO_0000115 "A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with mitogens, such as phytohemagglutinin (PHA)." ; dc:date "2017-09-02T15:57:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced lymphocyte proliferation to mitogen" ; a owl:Class ; rdfs:label "Decreased lymphocyte proliferation in response to mitogen" ; rdfs:subClassOf obo:HP_0031378 . obo:HP_0031382 obo:IAO_0000115 "A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with an anti-CD3 antibody against the T-cell co-receptor, CD3." ; dc:date "2017-09-02T15:57:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Defective lymphocyte proliferation to anti-CD3", "Defective proliferation of lymphocytes following anti-CD3 stimulation" ; a owl:Class ; rdfs:label "Decreased lymphocyte proliferation in response to anti-CD3" ; rdfs:subClassOf obo:HP_0031381 . obo:HP_0031383 obo:IAO_0000115 "Abnormal amount of a protein that is normally present on the cell surface of lymphocytes." ; dc:date "2017-09-02T16:14:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lymphocyte surface marker expression" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0031384 obo:IAO_0000115 "A deficiency in the expression of the CD40 ligand on the surface of activated T-lymphocytes." ; dc:date "2017-09-02T16:16:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be observed with X-linked Hyper IgM (XHIGM) syndrome. As a consequence of the deficiency in CD40 ligand, T-lymphocytes in patients with XHIGM are unable to instruct B-lymphocytes to switch their production of immunoglobulins from IgM to IgG, IgA and IgE." ; rdfs:label "Reduced T cell CD40 expression" ; rdfs:subClassOf obo:HP_0031383 . obo:HP_0031385 obo:IAO_0000115 "The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus." ; dc:date "2017-09-02T16:33:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Megakaryocytes with a hypolobulated nucleus can be seen in normal bone marrow but numbers are increased in some patients with myelodysplastic syndrome." ; rdfs:label "Megakaryocyte nucleus hypolobulation" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0031386 obo:IAO_0000115 "The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter." ; dc:date "2017-09-02T16:35:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Micromegakaryocytes are characteristic of myelodysplastic syndromebut may be seen in other conditions." ; rdfs:label "Increased micromegakaryocyte count" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0031387 obo:IAO_0000115 "The presence of abnormally high numbers of multinucleated megakaryocytes in the bone marrow." ; dc:date "2017-09-02T16:37:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A multinucleated megakaryocyte is a cell of normal size with two or more nuclei. Binucleated micromegakaryocytes should be categorized as such rather than as multinucleated megakaryocytes since the restricted size is of more diagnostic significance than the presence of two nuclei. Multinucleated megakaryocytes are seen in small numbers in normal bone marrow aspirates but in larger numbers in some patients with MDS." ; rdfs:label "Increased multinucleated megakaryocyte count" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0031388 obo:IAO_0000115 "The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus." ; dc:date "2017-09-02T16:40:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A large megakaryocyte with a hyperlobulated nucleus is a cell that is larger than average size and has more nuclear lobulation than average. Some such megakaryocytes are seen in normal bone marrows but when they are present as an increased proportion they should be commented on. Increased numbers are seen sometimes in myelodysplastic syndrome but they are more frequent in myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and in MPN, particularly essential thrombocythemia." ; rdfs:label "Megakaryocyte nucleus hyperlobulation" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0031389 obo:IAO_0000115 "A deviation from the normal level of major histocompatibility complex class II molecules expressed at the cell surface." ; dc:date "2017-09-02T17:00:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal MHC II surface expression" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0031390 obo:IAO_0000115 "A reduction from the normal level of major histocompatibility complex class II molecules expressed at the cell surface." ; dc:date "2017-09-02T17:00:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced MHC II surface expression" ; rdfs:subClassOf obo:HP_0031389 . obo:HP_0031391 obo:IAO_0000115 "An increase above the normal level of major histocompatibility complex class II molecules expressed at the cell surface." ; dc:date "2017-09-02T17:02:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated MHC II surface expression" ; rdfs:subClassOf obo:HP_0031389 . obo:HP_0031392 obo:IAO_0000115 "Any abnormality in the proportion of CD4-positive T cells relative to the total number of T cells." ; dc:date "2017-09-02T17:05:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of CD4+ T cells", "Abnormal proportion of CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Abnormal proportion of CD4-positive T cells" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031393 obo:IAO_0000115 "Any abnormality in the proportion of CD8 T cells relative to the total number of T cells." ; dc:date "2017-09-02T17:06:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of CD8+ T cells", "Abnormal proportion of CD8-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Abnormal proportion of CD8-positive T cells" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000625 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031394 obo:IAO_0000115 "Any abnormality in the relative amount of CD4+ and CD8+ T lymphocytes." ; dc:date "2017-09-02T17:06:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "CD4 helper/inducer cells and CD8 cytotoxic/suppressor cells are 2 phenotypes of T lymphocytes, characterized by distinct surface markers and functions that mostly reside in lymph nodes but also circulate in the blood. The normal CD4/CD8 ratio in healthy hosts is poorly defined. Ratios between 1.5 and 2.5 are generally considered normal; however, a wide heterogeneity exists because sex, age, ethnicity, genetics, exposures, and infections may all impact the ratio." ; rdfs:label "Abnormal CD4:CD8 ratio" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0031396 obo:IAO_0000115 "Any abnormality in the proportion of naive T cells relative to the total number of T cells." ; dc:date "2017-09-03T12:46:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal naive T cell proportion", "Abnormal proportion of naive thymus-derived, alpha-beta T cells" ; a owl:Class ; rdfs:comment "Following the development of T cells in the thymus, they enter the blood stream and recirculate between the blood and peripheral lymphatic tissues. Mature recirculating T cells that have not yet encountered their specific antigen are known as naive T cells. Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. Human mature CD4+ T cells are functionally heterogeneous and can be divided into naive and memory/effector populations based on the expression of cell surface markers. Although the most significant differences between these two populations are functional, the leukocyte common Ag (CD45) was promoted as a potential marker of memory T cells. CD45 Ag may be found in various isoforms depending on alternative splicing of three extracellularly expressed exons. The expression of the highest molecular weight isoform, referred to as CD45RA, defines the population of CD4+ unprimed lymphocytes. Activation of naive lymphocytes through TCR engagement is followed by loss of CD45RA Ag and transition to the expression of the smallest molecular weight isoform CD45RO. These primed cells express high levels of activation Ags, acquire effector functions, and need less costimuli requirements for further activation." ; rdfs:label "Abnormal proportion of naive T cells" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031397 obo:IAO_0000115 "An abnormally decreased proportion of naive T cells relative to the total number of T cells." ; dc:date "2017-09-03T12:53:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of naive thymus-derived, alpha-beta T cells", "Reduced proportion of naive T cells" ; a owl:Class ; rdfs:label "Decreased proportion of naive T cells" ; rdfs:subClassOf obo:HP_0031396 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031398 obo:IAO_0000115 "An abnormally increased proportion of naive T cells relative to the total number of T cells." ; dc:date "2017-09-03T12:53:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of naive T cells", "Increased proportion of naive thymus-derived, alpha-beta T cells" ; a owl:Class ; rdfs:label "Increased proportion of naive T cells" ; rdfs:subClassOf obo:HP_0031396 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031399 obo:IAO_0000115 "An abnormal proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells." ; dc:date "2017-09-03T12:57:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CD4-negative, CD8-negative, alpha-beta regulatory T cell distribution", "Abnormal DN Treg distribution", "Abnormal Double negative Treg distribution", "Abnormal double-negative alpha-beta regulatory T cell distribution" ; a owl:Class ; rdfs:comment "T lymphocytes bearing the alpha-beta T cell receptor (TCR) but lacking CD4, CD8, and markers of natural killer (NK) cell differentiation, i.e., TCR(+)CD3(+)CD4(-)CD8(-), are known as double-negative (DN) T cells and are defined by their capability of inhibiting immune responses via directly killing effector T cells in an antigen specific fashion. Furthermore, DN Treg cells have been shown to develop regulatory activity after encountering specific antigens, partially mediated by the acquisition of MHC-peptide complexes from antigen presenting cells (APCs)." ; rdfs:label "Abnormal proportion of double-negative alpha-beta regulatory T cell" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0031401 obo:IAO_0000115 "An abnormally decreased proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells." ; dc:date "2017-09-03T13:02:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells" ; rdfs:subClassOf obo:HP_0031399 . obo:HP_0031402 obo:IAO_0000115 "Impaired proliferation and expansion of a T cell population following activation by an antigenic stimulus." ; dc:date "2017-09-03T15:31:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Impaired cellular adaptive immune response" ; oboInOwl:hasExactSynonym "Antigen-specific T cell proliferation defect", "Impaired Ag-specific T cell proliferation", "Impaired activated T cell proliferation" ; a owl:Class ; rdfs:label "Reduced antigen-specific T cell proliferation" ; rdfs:subClassOf obo:HP_0031379, obo:HP_0031404 . obo:HP_0031403 obo:IAO_0000115 "Impaired response of CD8 T cells to pathogens. CD8 T cells direct the killing of a target cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." ; dc:date "2017-09-03T15:35:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pathogen-specific CD8 cytoxicity defect" ; a owl:Class ; rdfs:label "Impaired pathogen-specific CD8 cytoxicity" ; rdfs:subClassOf obo:HP_0031404 . obo:HP_0031404 obo:IAO_0000115 "An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." ; dc:date "2017-09-03T15:36:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired adaptive immune response" ; a owl:Class ; rdfs:label "Impaired antigen-specific response" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0002250 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031405 obo:IAO_0000115 "A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273]." ; dc:date "2017-09-03T15:57:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Poroma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0031406 obo:IAO_0000115 "Any abnormality in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." ; dc:date "2017-09-03T15:59:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cytokine signalling" ; a owl:Class ; rdfs:label "Abnormal cytokine signaling" ; rdfs:subClassOf obo:HP_0011111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031407 obo:IAO_0000115 "A defect or impairment in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." ; dc:date "2017-09-03T16:00:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cytokine signaling defect", "Cytokine signalling defect", "Impaired cytokine signalling" ; a owl:Class ; rdfs:label "Impaired cytokine signaling" ; rdfs:subClassOf obo:HP_0031406 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031408 obo:IAO_0000115 "An increased proportion of mast cells are positive for the cell surface marker CD25 (also called interleukin-2 receptor alpha chain)." ; dc:date "2017-09-04T11:55:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mast cells do not normally express CD25, but neoplastic mast cells may be CD25-positive. Aberrant expression of CD2 and/or CD25 by bone marrow, peripheral blood or other extracutaneous tissue mast cells is currently used as a minor World Health Organization diagnostic criterion for systemic mastocytosis. CD25 expression alone presented a similar sensitivity (100%) with a slightly higher specificity (99.2%)." ; rdfs:label "Increased proportion of CD25+ mast cells" ; rdfs:subClassOf obo:HP_0100494 . obo:HP_0031409 obo:IAO_0000115 "Any anomaly of lymphocyte function." ; dc:date "2017-09-04T12:08:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lymphocyte physiology" ; rdfs:subClassOf obo:HP_0011017, obo:HP_0033796 . obo:HP_0031410 obo:IAO_0000115 "An abnormal distribution in the number of CD56 bright NK cells, as measured by flow cytometry. CD56, an adhesion molecule mediating homotypic adhesion, is used as a functional marker for NK cells." ; dc:date "2017-09-04T12:15:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal distribution of CD56 bright/dim NK cells" ; a owl:Class ; rdfs:comment "The cytotoxic activity of CD56 dim NK cells is significantly higher than that of CD56 bright cells (the CD56bright CD16 population being the less cytotoxic) and they contain much more perforin, granzymes and cytolytic granules." ; rdfs:label "Abnormal distribution of CD56 bright/dim natural killer cells" ; rdfs:subClassOf obo:HP_0500033 . obo:HP_0031411 obo:IAO_0000115 "Any structural anomaly of a chromosome, which is a thread like molecule consisting of DNA and proteins (chromatin) that contains DNA sequences for genes and other genetic elements in linear order." ; dc:date "2017-09-04T15:22:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:4013" ; a owl:Class ; rdfs:label "Abnormal chromosome morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0031412 dc:date "2017-09-04T15:24:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal telomere morphology" ; rdfs:subClassOf obo:HP_0031411 . obo:HP_0031413 obo:IAO_0000115 "An abnormal reduction in telomere length. Telomeres are non-coding, repetitive sequences of DNA at the ends of the chromosomes of eukaryotic cells which become shorter as cells divide, and when telomere attrition reaches its limit, cell proliferation arrest, senescence, and apoptosis can occur." ; dc:date "2017-09-04T17:14:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Telomeres are made of repeating TTAGGG/AATCCC units. The overall length of the telomere is over 10 kb at birth and progressively declines with age." ; rdfs:label "Short telomere length" ; rdfs:subClassOf obo:HP_0031412 . obo:HP_0031414 obo:IAO_0000115 "An increased concentration of calcifediol in the blood. Calcifediol is also known as 25-hydroxycholecalciferol or 25-Hydroxyvitamin D3." ; dc:date "2017-09-12T01:49:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High serum 25-hydroxycholecalciferol", "High serum calcidiol" ; a owl:Class ; rdfs:label "High serum calcifediol" ; rdfs:subClassOf obo:HP_0100511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17933 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031415 obo:IAO_0000115 "An increased concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3." ; dc:date "2017-09-12T01:53:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0003152" ; oboInOwl:hasDbXref "UMLS:C1833331" ; oboInOwl:hasExactSynonym "High serum 1,25-dihydroxycholecalciferol", "High serum 1,25-dihydroxyvitamin D3", "Increased serum 1,25-dihydroxyvitamin D3", "Increased serum calcitriol" ; a owl:Class ; rdfs:label "High serum calcitriol" ; rdfs:subClassOf obo:HP_0100511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17823 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031416 obo:IAO_0000115 "Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose." ; dc:date "2017-09-12T02:03:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal nasal mucus secretion" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0031417 obo:IAO_0000115 "Increased discharge of mucus from the nose." ; dc:date "2017-09-12T02:06:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Nasal Discharge", "Runny Nose" ; a owl:Class ; rdfs:label "Rhinorrhea" ; rdfs:subClassOf obo:HP_0031416 . obo:HP_0031418 obo:IAO_0000115 "Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages." ; dc:date "2017-09-12T02:12:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased BMI" ; a owl:Class ; rdfs:label "Increased body mass index" ; rdfs:subClassOf obo:HP_0045081 . obo:HP_0031419 obo:IAO_0000115 "A decreased concentration of sex-hormone binding protein in the circulation." ; dc:date "2017-09-12T02:20:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced androgen-binding protein level" ; a owl:Class ; rdfs:comment "Sex hormone binding globulin (NCBI Gene 6462) is also known as sex hormone binding protein and androgen binding protein." ; rdfs:label "Reduced sex -hormone binding protein level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031420 obo:IAO_0000115 "A lesion that is observed following light damage to the macula. Damage to the retinal by exposure to intense visible light, usually the sun. Intense light exposure such as staring at the sun causes fine structural anomalies in the outer segments of the photoreceptors and the retinal pigment epithelium (RPE) cells of the macula. Symptoms usually develop within 1 to 4 h after exposure and include decreased vision, metamorphopsia, micropsia, and central or paracentral scotomas. Fundus examination typically shows a small yellow spot with a surrounding gray zone in the foveolar or parafoveolar area. Spontaneous evolution leads to the improvement of visual acuity." ; dc:date "2017-09-12T02:33:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Small yellow foveal lesion with surrounding grey zone" ; oboInOwl:hasRelatedSynonym "Laser pointer-induced maculopathy", "Laser pointer-induced retinopathy", "Light induced retinopathy", "Photic retinopathy", "Solar retinitis", "Solar retinopathy" ; a owl:Class ; rdfs:label "Small yellow foveal lesion with surrounding gray zone" ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0031421 obo:IAO_0000115 "Reduced size of the superior frontal portion of the cerebral cortex." ; dc:date "2017-09-16T11:11:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small superior frontal cortex" ; rdfs:subClassOf obo:HP_0002472 . obo:HP_0031422 obo:IAO_0000115 "Any structural anomaly of the cortex of the cerebellum." ; dc:date "2017-09-16T11:13:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal morphology of the cerebellar cortex" ; a owl:Class ; rdfs:label "Abnormal cerebellar cortex morphology" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0031423 obo:IAO_0000115 "Reduced size of the cerebellar cortex." ; dc:date "2017-09-16T11:14:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small cerebellar cortex" ; rdfs:subClassOf obo:HP_0031422 . obo:HP_0031424 obo:IAO_0000115 "A deviation from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation, a marker of the rate of bone turnover." ; dc:date "2017-09-16T11:18:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating beta-C-terminal telopeptide level", "Abnormal circulating beta-CTx level", "Abnormal circulating beta-CrossLaps level" ; a owl:Class ; rdfs:label "Abnormal circulating beta-C-terminal telopeptide concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031425 obo:IAO_0000115 "A abnormal elevation above the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation." ; dc:date "2017-09-16T11:22:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating beta-C-terminal telopeptide level", "Increased circulating beta-CTx level", "Increased circulating beta-CrossLaps level" ; a owl:Class ; rdfs:label "Increased circulating beta-C-terminal telopeptide concentration" ; rdfs:subClassOf obo:HP_0031424 . obo:HP_0031426 obo:IAO_0000115 "A reduction from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation." ; dc:date "2017-09-16T11:22:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating beta-C-terminal telopeptide level", "Decreased circulating beta-CTx level", "Decreased circulating beta-CrossLaps level" ; a owl:Class ; rdfs:label "Decreased circulating beta-C-terminal telopeptide concentration" ; rdfs:subClassOf obo:HP_0031424 . obo:HP_0031427 obo:IAO_0000115 "A deviation from the normal concentration of osteocalcin in the blood circulation." ; dc:date "2017-09-16T11:25:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Osteocalcin, also known as bone gamma-carboxyglutamic acid (Gla) protein (BGP), is the most abundant noncollagenous protein of bone matrix. It is released by osteoblasts during bone formation and binds with the mineralized bone matrix. Osteocalcin has an endocrine function, regulating glucose and lipid homeostasis." ; rdfs:label "Abnormal circulating osteocalcin level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0031428 obo:IAO_0000115 "An elevated level of osteocalcin in the blood." ; dc:date "2017-09-16T11:32:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating osteocalcin level" ; rdfs:subClassOf obo:HP_0031427 . obo:HP_0031429 obo:IAO_0000115 "A reduced level of osteocalcin in the blood." ; dc:date "2017-09-16T11:33:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating osteocalcin level" ; rdfs:subClassOf obo:HP_0031427 . obo:HP_0031430 obo:IAO_0000115 "The presence of a population of T cells with a restricted T cell receptor (TCR) repertoire derived from a limited number of TCR clones." ; dc:date "2017-09-16T12:00:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oligoclonal T cell expansion" ; rdfs:subClassOf obo:HP_0011840 . obo:HP_0031431 obo:IAO_0000115 "Repetition of sounds with no meaning." ; dc:date "2017-09-16T12:14:57Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Persistent repetition of sounds" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_0031432 obo:IAO_0000115 "A broad range of compulsive behaviors that are repeated including simple motor stereotypies and tics as well as more complex repetitive movements or compulsions." ; dc:date "2017-09-16T12:17:41Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:comment "Simple motor stereotypies often involve rhythmic or repetitive movements of specific components of the body including upper extremities or head and face, whereas more complex repetitive movements often include whole body movements (e.g., body rocking, self-hugging)." ; rdfs:label "Restricted or repetitive behaviors or interests" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0031433 obo:IAO_0000115 "A deficit in emotional awareness characterized by difficulties in recognizing and expressing feelings and emotions manifested as a limited ability to respond to facial clues or other signs of emotions in others often accompanied by detached connections to others." ; dc:date "2017-09-16T12:21:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Unaware of others' emotions" ; a owl:Class ; rdfs:label "Alexithymia" ; rdfs:subClassOf obo:HP_0000729 . obo:HP_0031434 obo:IAO_0000115 "Abnormalities in the patterns of rhythm, stress, or intonation of speech or vocalization." ; dc:date "2017-09-16T12:34:05Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal prosody" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_0031435 obo:IAO_0000115 "A speech pattern characterized by an abnormal lack of tone in the voice." ; dc:date "2017-09-16T12:36:08Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Flat speech" ; a owl:Class ; rdfs:comment "Often accompanied by reduced variation of rate and rhythm." ; rdfs:label "Monotonic speech" ; rdfs:subClassOf obo:HP_5200010 . obo:HP_0031436 obo:IAO_0000115 "A speech pattern characterized by abnormal fluctuations in the pitch of the voice." ; dc:date "2017-09-16T12:39:11Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Melodic speech", "Sing song intonation", "Sing-song intonation" ; a owl:Class ; rdfs:comment "Often accompanied by altered speech rate and rhythm." ; rdfs:label "Singsong Intonation" ; rdfs:subClassOf obo:HP_5200010 . obo:HP_0031437 obo:IAO_0000115 "Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants." ; dc:date "2017-09-16T13:01:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Exposure during pregnancy" ; a owl:Class ; rdfs:label "Pregnancy exposure" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0031438 obo:IAO_0000115 "A deviation from the normal concentration in the circulation of sex hormone-binding globulin, a circulating glycoprotein that transports testosterone and other steroids in the blood." ; dc:date "2017-09-17T12:29:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sex hormone-binding globulin (SHBG, Gene ID: 6462) binds the three sex hormones estrogen, dihydrotestosterone (DHT), and testosterone. Reduction in the level of SHBG can result in an increased level of free (unbound, and therefore active) sex hormones." ; rdfs:label "Abnormal sex hormone-binding globulin level" ; rdfs:subClassOf obo:HP_0025465 . obo:HP_0031439 obo:IAO_0000115 "A deviation from the normal concentration in the circulation of angiostatin, an endogenous angiogenesis inhibitor, which blocks the growth of new blood vessels." ; dc:date "2017-09-17T12:31:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Angiostatin is an internal fragment of plasminogen that specifically inhibits endothelial cell proliferation and migration, and by promoting endothelial apoptosis." ; rdfs:label "Abnormal angiostatin level" ; rdfs:subClassOf obo:HP_0025465 . obo:HP_0031440 obo:IAO_0100001 "HP:0001702" ; a owl:Class ; rdfs:label "obsolete Abnormal tricuspid valve morphology" ; owl:deprecated true . obo:HP_0031441 obo:IAO_0000115 "Any structural anomaly of the annulus of the tricuspid valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach." ; dc:date "2017-09-17T13:06:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal tricuspid valve annulus morphology" ; rdfs:subClassOf obo:HP_0001702 . obo:HP_0031442 obo:IAO_0000115 "Any structural anomaly of the chordae tendinae of the tricuspid valve. The chordae tendineae connect the papillary muscles to the tricuspid valve." ; dc:date "2017-09-17T13:37:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal tricuspid chordae tendinae morphology" ; rdfs:subClassOf obo:HP_0001702 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014852 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031443 obo:IAO_0000115 "Any structural anomaly of the leaflets (also known as cusps) of the tricuspid valve." ; dc:date "2017-09-17T13:42:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal tricuspid valve leaflet morphology" ; rdfs:subClassOf obo:HP_0001702 . obo:HP_0031444 obo:IAO_0000115 "An increase in the diameter of the ring (annulus) of the tricuspid valve." ; dc:date "2017-09-17T13:52:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dilatation of the tricuspid annulus" ; rdfs:subClassOf obo:HP_0031441 . obo:HP_0031445 obo:IAO_0000115 "A palpable, solid lesion greater than 5mm in diameter. that is located in the mucosa of the mouth." ; dc:date "2017-09-17T14:16:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oral mucosa nodule" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0031446 obo:IAO_0000115 "Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion." ; dc:date "2017-09-17T14:19:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Erosion of oral mucosa" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0031447 obo:IAO_0000115 "Multiple pigmented macules located on the skin of the penis." ; dc:date "2017-09-17T14:28:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Penile freckling" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0031448 obo:IAO_0000115 "Multiple vesicles distributed in multiple distinct groups consisting of multiple adjacent vesicles." ; dc:date "2017-09-17T14:44:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Herpetiform vesicles" ; rdfs:subClassOf obo:HP_0200037 . obo:HP_0031449 obo:IAO_0000115 "Hemangioma, a benign tumor of the vascular endothelial cells, located in the perineal region, i.e., the region between the anus and the genitals." ; dc:date "2017-09-17T14:49:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perineal hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0031450 obo:IAO_0000115 "A distribution of skin lesions resembling multiple merged circles. For instance, this can be seen with multiple urticarial wheals as the individual, circular wheals resolve and merge." ; dc:date "2017-09-17T15:00:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polycyclic" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0031451 obo:IAO_0000115 "An abnormal increase in the amount of subcutaneous fat in the legs." ; dc:date "2017-09-17T15:21:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lower extremity subcutanous fat hypertrophy" ; rdfs:subClassOf obo:HP_0009124 . obo:HP_0031452 obo:IAO_0000115 "Mutliple skin lesions resembling those characteristic of the disease lichen planus. These lesions are violaceous (reddish-purple), shiny, isolated, flat-topped papules and plaques." ; dc:date "2017-09-17T15:34:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lichenoid skin lesion" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0031453 obo:IAO_0000115 "Mutliple lesions of the oral mucosa resembling those characteristic of the disease lichen planus. These are symmetric reticular lesions that resemble a white, lacelike network, as well as by papules, plaques, erythematous lesions, and erosions." ; dc:date "2017-09-17T15:39:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oral lichenoid lesion" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0031454 obo:IAO_0000115 "A cystic lesions that forms a benign tumor of an apocrine sweat gland." ; dc:date "2017-09-17T15:50:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Apocrine hidrocystoma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0031455 obo:IAO_0000115 "A gangioleneuroma originating from sympathetic ganglion cells in the abdomen." ; dc:date "2017-09-17T15:53:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Presacral ganglioneuroma" ; rdfs:subClassOf obo:HP_0003005 . obo:HP_0031456 obo:IAO_0000115 "A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube)." ; dc:date "2017-09-17T15:55:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ectopic pregnancy" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0031457 obo:IAO_0000115 "Opacity refers to any area that preferentially attenuates the x-ray beam and therefore appears more opaque than the surrounding area. It is a nonspecific term that does not indicate the size or pathologic nature of the abnormality." ; dc:date "2017-09-17T15:59:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Increased pulmonary opacity is caused by a decrease in the ratio of gas to soft tissue (blood, lung parenchyma and stroma) in the lung." ; rdfs:label "Pulmonary opacity" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0031458 obo:IAO_0000115 "An inflammation of the adenoid tissue." ; dc:date "2017-09-17T16:02:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Adenoiditis is usually caused by an infection." ; rdfs:label "Adenoiditis" ; rdfs:subClassOf obo:HP_3000033 . obo:HP_0031459 obo:IAO_0000115 "A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms." ; dc:date "2017-09-17T16:05:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Soft tissue neoplasm" ; rdfs:subClassOf obo:HP_0011793 . obo:HP_0031460 obo:IAO_0000115 "A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue [NCIT:C4882]." ; dc:date "2017-09-17T16:08:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Benign muscle neoplasm" ; rdfs:subClassOf obo:HP_0031459 . obo:HP_0031461 obo:IAO_0000115 "A benign tumor that is usually solitary, painless, palpable mass that is firm in consistency and slightly movable and often fluctuant. It can occur in any location, but tends to involve the muscles of the thighs, buttocks, and shoulders. On microscopic examination, there is abundant mucoid material and relative hypo cellularity and loose reticulin fibers. Vascular structures are sparse. The cells have a stellate shape with small hyper chromatic pyknotic nuclei and scanty cytoplasm. Some myxomas may show focal areas of hyper cellularity. However absence of nuclear atypia, mitotic figures or necrosis helps to rule out malignancy." ; dc:date "2017-09-17T16:09:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IM Myxoma" ; a owl:Class ; rdfs:label "Intramuscular Myxoma" ; rdfs:subClassOf obo:HP_0031460 . obo:HP_0031462 obo:IAO_0000115 "Abnormal reduction in length of a tendon which tends to pull (retract) the attached muscle tissue with shortening of the muscle fibers often accompanied by atrophy and fatty degeneration of the affected muscle tissue." ; dc:date "2017-09-17T16:13:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Musculotendinous retraction" ; rdfs:subClassOf obo:HP_0003549 . obo:HP_0031463 obo:IAO_0000115 "A rare benign epithelial tumor that is usually asymptomatic but can present with pyrosis and epigastric discomfort with or without dysphagia. Histopathologically, esophageal squamous papilloma has fingerlike projections lined with acanthotic stratified squamous epithelium with conservation of normal cellular with or without cellular atypia." ; dc:date "2017-09-17T16:18:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophageal squamous papilloma" ; rdfs:subClassOf obo:HP_0100751 . obo:HP_0031464 obo:IAO_0000115 "The presence of one or more bullae on the skin of the genital region, defined as fluid-filled blisters more than 5 mm in diameter with thin walls." ; dc:date "2017-09-17T16:21:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Genital blistering" ; rdfs:subClassOf obo:HP_0033800 . obo:HP_0031465 obo:IAO_0000115 "A structural anomaly of vasa vasorum, which are defined as small blood vessels that supply or drain the walls of larger arteries and veins, delivering nutrients and oxygen as well as removing systemic waste products." ; dc:date "2017-09-17T16:23:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vasa vasorum morphology" ; rdfs:subClassOf obo:HP_0033353 . obo:HP_0031466 obo:IAO_0000115 "A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning." ; dc:date "2017-09-17T16:30:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The emergence of the self in childhood and adolescence is based on experience and perception, which then becomes organized into identity, which organizes further experience and perception. Identity is related to the individual's selfsameness and continuity in time." ; rdfs:label "Impairment in personality functioning" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0031467 obo:IAO_0000115 "A stable tendency to experience negative emotions, i.e., a disposition to experience aversive emotional states." ; dc:date "2017-09-17T16:33:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Negative affectivity" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0031468 obo:IAO_0000115 "Fears of rejection by and/or separation from significant others, associated with fears of excessive dependency and complete loss of autonomy." ; dc:date "2017-09-17T16:39:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Separation insecurity" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0031469 obo:IAO_0000115 "Negative opinion about oneself characterized by low self-confidence and exaggeratedly critical feelings about oneself." ; dc:date "2017-09-17T16:41:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Low self esteem" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0031472 obo:IAO_0000115 "Engagement in dangerous, risky, and potentially self-damaging activities, unnecessarily and without regard to consequences; lack of concern for one's limitations and denial of the reality or personal danger." ; dc:date "2017-09-17T16:44:22Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Risk taking" ; rdfs:subClassOf obo:HP_0000734 . obo:HP_0031473 obo:IAO_0000115 "Persistent or frequent angry feelings; anger or irritability in response to minor slights and insults." ; dc:date "2017-09-17T16:45:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hostility" ; rdfs:subClassOf obo:HP_0031466 . obo:HP_0031474 obo:IAO_0000115 "A benign cartilaginous tumors of the lung." ; dc:date "2017-09-17T16:50:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary chondroma" ; rdfs:subClassOf obo:HP_0100526 . obo:HP_0031475 obo:IAO_0000115 "There is inconclusive evidence to precisely define the duration of the seizure; however, based on current evidence an operational threshold of 10 minutes is appropriate as beyond this a seizure is likely to be more prolonged. The individual may or may not be aware or in coma." ; dc:date "2017-09-17T16:57:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Nonconvulsive status epilepticus" ; a owl:Class ; rdfs:label "Status epilepticus without prominent motor symptoms" ; rdfs:subClassOf obo:HP_0002133 . obo:HP_0031476 obo:IAO_0000115 "Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells)." ; dc:date "2017-09-17T22:04:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Buccal mucosa cells are easy to obtain and are a useful model of some other diseases. For instance, muccal mucosa cells from arrhythmogenic cardiomyopathy patients exhibit changes in the distribution of cell junction proteins similar to those seen in the heart." ; rdfs:label "Abnormal buccal mucosa cell morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0031477 obo:IAO_0100001 "HP:0001633" ; a owl:Class ; rdfs:label "obsolete Abnormal mitral valve morphology" ; owl:deprecated true . obo:HP_0031478 obo:IAO_0000115 "Any structural anomaly of the annulus of the mitral valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach." ; dc:date "2017-09-17T22:28:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal mitral valve annulus morphology" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0031479 obo:IAO_0000115 "An increase in the diameter of the ring (annulus) of the mitral valve." ; dc:date "2017-09-17T22:28:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dilatation of the mitral annulus" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0031480 obo:IAO_0000115 "Any structural anomaly of the leaflets (also known as cusps) of the mitral valve." ; dc:date "2017-09-17T22:30:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal mitral valve leaflet morphology" ; rdfs:subClassOf obo:HP_0001633 . obo:HP_0031481 obo:IAO_0000115 "Any functional anomaly of the mitral valve." ; dc:date "2017-09-17T22:37:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal mitral valve physiology" ; rdfs:subClassOf obo:HP_0031650 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002135 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031482 obo:IAO_0000115 "A wall motion abnormality observed upon left ventricular contraction that affects a specific region of the left ventricle." ; dc:date "2017-09-17T22:44:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal regional left ventricular contraction" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0031483 obo:IAO_0000115 "Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography." ; dc:date "2017-09-17T22:45:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced contraction of the left ventricular apex" ; rdfs:subClassOf obo:HP_0031482 . obo:HP_0031484 obo:IAO_0000115 "A form of hemolytic anemia that can be triggered by cold temperatures." ; dc:date "2017-09-17T23:00:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cold-induced hemolysis" ; rdfs:subClassOf obo:HP_0001878 . obo:HP_0031485 obo:IAO_0000115 "The formation of new bone along the cortex and underneath the periosteum of a bone." ; dc:date "2017-09-17T23:02:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Periosteal reaction" ; a owl:Class ; rdfs:label "Subperiosteal bone formation" ; rdfs:subClassOf obo:HP_0030313 . obo:HP_0031486 obo:IAO_0000115 "An anomaly of blood vessels located in the lip." ; dc:date "2017-09-18T00:21:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vascular malformation of the lip" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0031487 obo:IAO_0000115 """A vascular malformation located in the lip that is characterized by ectatic papillary dermal capillaries and postcapillary venules in the upper reticular dermis.""" ; dc:date "2017-09-18T00:22:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Capillary malformation of the lip" ; rdfs:subClassOf obo:HP_0031486 . obo:HP_0031488 obo:IAO_0000115 "A vascular malformation located in the lip that is characterized by direct blood shunting from an artery to a vein due to the absence of a capillary bed. The artery and vein can be directly connected by a fistula or indirectly connected by an abnormal vessel channel termed a nidus." ; dc:date "2017-09-18T00:24:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atypical connection between arteries and veins" ; a owl:Class ; rdfs:label "Arteriovenous malformation of the lip" ; rdfs:subClassOf obo:HP_0031486 . obo:HP_0031489 obo:IAO_0000115 "A vascular malformation located in the lip that is related to abnormal vascular morphogenesis." ; dc:date "2017-09-18T00:26:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Venous malformation of the lip" ; rdfs:subClassOf obo:HP_0031486 . obo:HP_0031490 obo:IAO_0000115 "A vascular malformation located in the lip that is related to vascular endothelial cell hyperplasia." ; dc:date "2017-09-18T00:28:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hemangioma of the lip" ; rdfs:subClassOf obo:HP_0001028, obo:HP_0031486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001028 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031491 obo:IAO_0000115 "Diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep." ; dc:date "2017-09-18T00:34:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CSWS", "Electrical status epilepticus during slow-wave sleep" ; a owl:Class ; rdfs:label "Continuous spike and waves during slow sleep" ; rdfs:subClassOf obo:HP_0025373 . obo:HP_0031492 obo:IAO_0000115 "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709]." ; dc:date "2017-09-18T00:40:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Epithelial neoplasm is a benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas." ; rdfs:label "Epithelial neoplasm" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0031493 obo:IAO_0000115 "A tumor that arises from a gland cell." ; dc:date "2017-09-18T00:42:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glandular cell neoplasm" ; rdfs:subClassOf obo:HP_0031492 . obo:HP_0031494 obo:IAO_0000115 "Ovarian mucinous neoplasms consist of borderline tumors (tumors of low malignant potential, or LMP tumors), intraepithelial (non-invasive) carcinoma, and invasive carcinoma." ; dc:date "2017-09-18T00:44:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mucinous neoplasm of the ovary", "Ovarian mucinous tumour" ; a owl:Class ; rdfs:label "Ovarian mucinous tumor" ; rdfs:subClassOf obo:HP_0031495 . obo:HP_0031495 dc:date "2017-09-18T00:48:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mucinous neoplasm" ; rdfs:subClassOf obo:HP_0031493 . obo:HP_0031496 obo:IAO_0000115 "Mucin-producing and septated cyst-forming epithelial neoplasia of the pancreas with a distinctive ovarian-type stroma." ; dc:date "2017-09-18T00:49:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mucinous cystic neoplasm of the pancreas" ; rdfs:subClassOf obo:HP_0031495 . obo:HP_0031497 obo:IAO_0000115 "A subtype of colorectal carcinoma with mucin lakes." ; dc:date "2017-09-18T00:52:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mucinous colorectal carcinoma" ; rdfs:subClassOf obo:HP_0031495 . obo:HP_0031498 obo:IAO_0000115 "A poorly differentiated type of gastric carcinoma with a substantial amount of extracellular mucus (over 50% of tumor volume) within the tumor." ; dc:date "2017-09-18T00:55:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mucinous gastric carcinoma" ; rdfs:subClassOf obo:HP_0031495 . obo:HP_0031499 obo:IAO_0000115 "An epithelial neoplasm originating in the appendix and often associated with cystic dilation of the appendix due to accumulation of gelatinous material, morphologically referred to as mucoceles." ; dc:date "2017-09-18T00:59:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Appendiceal mucinous neoplasm" ; rdfs:subClassOf obo:HP_0031495 . obo:HP_0031500 obo:IAO_0000115 "An abnormal enlargement or swelling in the abdomen." ; dc:date "2017-09-18T01:02:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abdominal mass" ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0031501 obo:IAO_0000115 "An abnormal enlargement or swelling in the pelvic region." ; dc:date "2017-09-18T01:03:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pelvic mass" ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0031502 obo:IAO_0000115 "A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells [NCIT:C3422]." ; dc:date "2017-09-18T01:07:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trophoblastic tumour" ; a owl:Class ; rdfs:label "Trophoblastic tumor" ; rdfs:subClassOf obo:HP_0100728 . obo:HP_0031503 obo:IAO_0000115 "Waking up at night gasping for breath." ; dc:date "2017-09-18T01:14:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Night gasping" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0031504 obo:IAO_0000115 "Urine has an increased amount of frothy fine bubbles." ; dc:date "2017-09-18T01:16:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Frothy urine" ; a owl:Class ; rdfs:label "Foamy urine" ; rdfs:subClassOf obo:HP_0033072 . obo:HP_0031505 obo:IAO_0000115 "A deviation from the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3)." ; dc:date "2017-09-21T01:52:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating T4 level", "Abnormal circulating thyroxine level" ; a owl:Class ; rdfs:label "Abnormal circulating T4 concentration" ; rdfs:subClassOf obo:HP_0031508 . obo:HP_0031506 obo:IAO_0000115 "An elevation above the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3)." ; dc:date "2017-09-21T01:54:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating T4 level", "Increased circulating thyroxine level" ; a owl:Class ; rdfs:label "Increased circulating T4 concentration" ; rdfs:subClassOf obo:HP_0031505 . obo:HP_0031507 obo:IAO_0000115 "A reduction below the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3)." ; dc:date "2017-09-21T01:55:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating T4 level", "Decreased circulating thyroxine level", "Reduced T4 plasma level" ; a owl:Class ; rdfs:label "Decreased circulating T4 concentration" ; rdfs:subClassOf obo:HP_0031505 . obo:HP_0031508 obo:IAO_0000115 "Any deviation from the normal range of the hormones produced by the thyroid gland." ; dc:date "2017-09-21T01:56:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal thyroid hormone level" ; a owl:Class ; rdfs:comment "Thyroid hormones (TH) are involved in the regulation of metabolism, proliferation, and growth of most tissues. Serum TH levels are tightly controlled by the hypothalamic, pituitary, and thyroid (HPT) axis to deliver appropriate amounts of TH to target tissues. The two major THs (T3 and T4) are iodothyrosines synthesized by the thyroid gland under the control of thyrotropin/thyroid stimulating hormone (TSH), a glycoprotein heterodimer that is produced by the pituitary gland. TSH, in turn, is regulated by thyrotropin releasing hormone (TRH), a tripeptide generated by the hypothalamus that is released into its own portal system to reach the pituitary. Both the production of TRH and TSH are under negative feedback control determined by the circulating free TH concentrations." ; rdfs:label "Abnormal circulating thyroid hormone concentration" ; rdfs:subClassOf obo:HP_0002926, obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_60311 ] ) ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031509 obo:IAO_0000115 "Abnormally dry skin in the area of the nipple of the breast." ; dc:date "2017-09-21T02:19:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dry nipple" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001801 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002030 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031510 obo:IAO_0000115 "A transverse linear fissure (crease) in the lobule of the ear." ; dc:date "2017-09-21T03:01:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature may be observed in Beckwith Wiedemann syndrome." ; rdfs:label "Linear earlobe crease" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0031511 obo:IAO_0000115 "Diagonal earlobe creases run from the lower pole of the external meatus, diagonally backwards to the edge of the lobe at approximately 45 degrees." ; dc:date "2017-09-21T03:03:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diagonal earlobe crease" ; rdfs:subClassOf obo:HP_0000363 . obo:HP_0031512 dc:date "2017-09-22T01:31:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An anomaly of the collagen fibers located in the skin." ; rdfs:label "Abnormal cutaneous collagen fibril morphology" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0031513 obo:IAO_0000115 "Fusiform collagen fibers with abnormally long spacing (exceeding 100 nm) between electron-dense bands." ; dc:date "2017-09-22T01:34:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The periodicity of normal collagen fibers is substantially lower than that of Luse bodies." ; rdfs:label "Luse bodies" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0031514 obo:IAO_0000115 "An abnormally elevated proportion of exhausted T cells (Tex) among circulating T cells. T cell exhaustion is a distinct differentiation state that can be distinguished from naive, effector, and memory T cells. Compared to effector (TE) and memory (TMEM) T cells, exhausted T cells (TEX) display impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity). TEX have limited proliferative potential, especially compared to some subsets of TMEM and naive T cells." ; dc:date "2017-09-22T02:12:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of exhausted T cells" ; rdfs:subClassOf obo:HP_0025540, obo:HP_0041080 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0011025 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031515 obo:IAO_0000115 "Any anomaly of meiosis, a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells." ; dc:date "2017-09-22T02:18:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal meiosis" ; rdfs:subClassOf obo:HP_0033337 . obo:HP_0031516 obo:IAO_0000115 "Failure of oocytes to proceed through the stages of meiosis with stoppage at the first metaphase stage." ; dc:date "2017-09-22T02:21:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Metaphase I oocyte meiotic arrest", "Oocyte meiotic arrest at metaphase I" ; a owl:Class ; rdfs:comment "An essential feature of successful mammalian reproduction is the fusion of a sperm with a metaphase II oocyte. Oocytes are first arrested at prophase I and resume meiosis in response to luteinizing hormone (LH). Following spindle assembly and extrusion of the first polar body, oocytes are again arrested at metaphase II until fertilization.Failure of oocytes to progress beyond metaphase I of meiosis." ; rdfs:label "Oocyte arrest at metaphase I" ; rdfs:subClassOf obo:HP_0034914 . obo:HP_0031517 obo:IAO_0000115 "A papillary or cauliflower-like growth characterized by the presence of foamy histiocytes within the elongated dermal papillae forms." ; dc:date "2017-09-22T02:25:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This lesion is seen chiefly in the oral mucosa." ; rdfs:label "Verruciform xanthoma" ; rdfs:subClassOf obo:HP_0000991 . obo:HP_0031518 obo:IAO_0000115 "Lack of normal alpha rhythm in the EEG. Alpha rhythm has been defined as a rhythm at 8-13 Hz occurring during wakefulness over the posterior regions of the head, generally with higher voltage over the occipital areas. Amplitude is variable but is mostly below 50 microvolt in adults. It is best seen with eyes closed and under conditions of physical relaxation and relative mental inactivity. It is blocked or attenuated by attention, especially visual and mental effort. One should here note the difference between the terms alpha rhythm and alpha activity: Alpha activity refers to activity in the range of 8-13 Hz and alpha rhythm is the activity of 8-13 Hz with specific characteristics as defined above." ; dc:date "2017-09-22T02:28:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent posterior alpha rhythm" ; rdfs:subClassOf obo:HP_0025373 . obo:HP_0031519 obo:IAO_0000115 "An anomaly of collagen fibers of the skin that is said to resemble a cauliflower and can be appreciated by electron microscopy." ; dc:date "2017-09-22T02:32:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cauliflower deformity of dermal collagen fibrils" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0031520 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the groin region." ; dc:date "2017-09-22T02:40:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Groin pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0031521 obo:IAO_0000115 "A type of adenocarcinoma originating in the vagina and characterized by large cells with moderate to abundant clear cytoplasm." ; dc:date "2017-09-23T01:45:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clear cell adenocarcinoma of the vagina" ; a owl:Class ; rdfs:label "Vaginal clear cell adenocarcinoma" ; rdfs:subClassOf obo:HP_0100650 . obo:HP_0031522 obo:IAO_0000115 "A type of adenocarcinoma originating in the cervix and characterized by large cells with moderate to abundant clear cytoplasm." ; dc:date "2017-09-23T01:51:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clear cell carcinoma of cervix" ; a owl:Class ; rdfs:label "Cervical clear cell adenocarcinoma" ; rdfs:subClassOf obo:HP_0100650 . obo:HP_0031523 obo:IAO_0000115 "A benign epithelial neoplasm composed of layers of oncocytes (small round nucleus, micro-granular, eosinophilic cytoplasm with numerous tightly-packed mitochondria)" ; dc:date "2017-09-23T01:57:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Parotid oncocytoma" ; a owl:Class ; rdfs:comment "Most cases of salivary gland oncocytoma occur in the parotid gland." ; rdfs:label "Salivary gland oncocytoma" ; rdfs:subClassOf obo:HP_0100684 . obo:HP_0031524 obo:IAO_0000115 "A carcinoma originating in the ampulla of Vater (also known as the hepatopancreatic duct), which is formed by the union of the pancreatic duct and the common bile duct." ; dc:date "2017-09-23T02:03:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ampulla of Vater carcinoma" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0031525 obo:IAO_0000115 "Keratoacanthoma (KA) is a common benign epithelial tumor that originates from the pilosebaceous glands. In most cases, it is characterized by rapid evolution, followed by spontaneous resolution over 4 to 6 months. KA usually presents as a solitary flesh-coloured nodule with a central keratin plug on the sun-exposed skin of elderly individuals." ; dc:date "2017-09-23T02:14:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Keratoacanthoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0031526 obo:IAO_0000115 "Edema/fluid accumulating between the retinal pigment epithelium and Bruch's membrane." ; dc:date "2017-09-24T00:47:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sub-retinal fluid" ; a owl:Class ; rdfs:label "Subretinal fluid" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0031527 obo:IAO_0000115 "Edema/fluid accumulating within the retinal layers." ; dc:date "2017-09-24T00:47:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intra-retinal fluid" ; a owl:Class ; rdfs:label "Intraretinal fluid" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0031528 obo:IAO_0000115 "Deposits accumulating between the outer retina and the retinal pigment epithelium." ; dc:date "2017-09-24T00:49:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subretinal deposits" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0031529 obo:IAO_0000115 "Deposits accumulating between the outer retina and the retinal pigment epithelium and that have a focal distribution." ; dc:date "2017-09-24T00:49:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal subretinal deposits" ; rdfs:subClassOf obo:HP_0031528 . obo:HP_0031530 obo:IAO_0000115 "Deposits accumulating between the outer retina and the retinal pigment epithelium and that are distributed with multiple foci." ; dc:date "2017-09-24T00:49:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Multifocal subretinal deposits" ; rdfs:subClassOf obo:HP_0031528 . obo:HP_0031531 obo:IAO_0000115 "Deposits accumulating between the retinal pigment epithelium and Bruch's membrane." ; dc:date "2017-09-24T00:50:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is related to Subretinal hyporeflective spaces on macular OCT." ; rdfs:label "Sub-RPE deposits" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0031532 obo:IAO_0000115 "Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in a single focus." ; dc:date "2017-09-24T00:51:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal sub-RPE deposits" ; rdfs:subClassOf obo:HP_0031531 . obo:HP_0031533 obo:IAO_0000115 "Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in multiple foci." ; dc:date "2017-09-24T00:51:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Multifocal sub-RPE deposits" ; rdfs:subClassOf obo:HP_0031531 . obo:HP_0031534 obo:IAO_0000115 "An abnormally increased ability to bend (dorsiflex) one's fifth finger. To assess this feature, the examiner requests to proband to extend the elbows,to bend the wrist back so that it forms a ninety degree angle to the forearm, and to extend the fingers. Then, the proband is requested to bend the fifth finger back as far as is possible without discomfort. If the angle of the fifth finger exceeds 90 degrees, this is considered to be abnormal." ; dc:date "2017-09-24T00:56:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is tested on the right and left side and if positive, each feature contributes one point to the Beighton score." ; rdfs:label "Passive dorsiflexion of the 5th finger more than 90 degrees" ; rdfs:subClassOf obo:HP_0004207 . obo:HP_0031535 obo:IAO_0000115 "Increased frequency of theta wave activity in the electroencephalogram. Theta waves have a frequency of 3.5-7.5 Hertz, and are present in very small amounts in healthy waking adult EEGs. Theta activity is normal in small very amounts in the healthy waking adult EEG in a symmetrical distribution." ; dc:date "2017-09-24T01:03:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased theta frequency activity in EEG" ; rdfs:subClassOf obo:HP_0025373 . obo:HP_0031536 obo:IAO_0000115 "Anomalous coronary origin whereby the left anterior descending (LAD) and the left circumflex artery (LCX) arise separately. Normally, these arteries arise from a common stem, the left main coronary artery (LMCA)." ; dc:date "2017-09-24T01:16:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Separate origin of the left anterior descending and left circumflex artery" ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0031537 obo:IAO_0000115 "An abnormal origin of the left circumflex artery (LCX) from the right coronary artery. Normally, the left anterior descending (LAD) and the LCX arise from a common stem, the left main coronary artery (LMCA)." ; dc:date "2017-09-24T01:19:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of the left circumflex artery from the right coronary artery" ; rdfs:subClassOf obo:HP_0025505 . obo:HP_0031538 obo:IAO_0000115 "Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments." ; dc:date "2017-09-24T01:32:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal dermoepidermal junction morphology" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0031539 obo:IAO_0000115 "Presence of IgA antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." ; dc:date "2017-09-24T01:33:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Linear IgA deposits along the epidermal basement membrane zone" ; rdfs:subClassOf obo:HP_0031538 . obo:HP_0031540 obo:IAO_0000115 "Presence of IgG antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." ; dc:date "2017-09-24T01:35:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Linear IgG deposits along the epidermal basement membrane zone" ; rdfs:subClassOf obo:HP_0031538 . obo:HP_0031541 obo:IAO_0000115 "Presence of complement C3 in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." ; dc:date "2017-09-24T01:36:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Linear C3 deposits along the epidermal basement membrane zone" ; rdfs:subClassOf obo:HP_0031538 . obo:HP_0031542 obo:IAO_0000115 "Muscle fibers contain one or more vacuoles (membrane-bound cavity) associated with collections of membranes arranged in a whorl-like (spiral or circular) manner." ; dc:date "2017-09-24T01:38:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myelin-like whorls in vacuolated fibres" ; a owl:Class ; rdfs:label "Myelin-like whorls in vacuolated fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0031544 obo:IAO_0000115 "An elevated level of propionylcarnitine in the circulation. Propionylcarnitine is present in high abundance in the urine of patients with Methylmalonyl-CoA mutase (MUT) deficiency." ; dc:date "2017-09-24T01:57:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0033463" ; oboInOwl:hasExactSynonym "Elevated circulating O-propionylcarnitine concentration", "Elevated plasma palmitoleylcarnitine, C16:1", "Elevated plasma propionylcarnitine, C3:0", "Elevated propionylcarnitine level" ; a owl:Class ; rdfs:label "Elevated circulating palmitoleylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0031545 obo:IAO_0000115 "Reduced level of T cell receptor excision circle (TRECs) as measured by the TREC assay. Late in maturation, 70% of thymocytes that will ultimately express alpha/beta-T cell receptors form a circular DNA TREC from the excised TCRdelta gene that lies within the TCRalpha genetic locus. The circles are stable but do not increase following cell division and, therefore, become diluted as T cells proliferate. A quantitative polymerase chain reaction (PCR) reaction across the joint of the circular DNA provides the TREC copy number, a marker of newly-formed, antigenically-naïve thymic emigrant T cells." ; dc:date "2017-09-24T22:20:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "T-cell receptor excision circle (TRECs) are extrachromosomal DNA byproducts of T-cell receptor rearrangement and are nonreplicative. TREC analysis provides a very specific assessment of T-cell recovery (eg, after hematopoietic cell transplantation) or numerical T-cell competence" ; rdfs:label "Abnormally low T cell receptor excision circle level" ; rdfs:subClassOf obo:HP_0011839 . obo:HP_0031546 obo:IAO_0000115 "Any anomaly of the progression of electrical impulses through the heart." ; dc:date "2017-09-24T22:36:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of cardiac conduction", "Abnormality of cardiac conduction system", "Cardiac conduction abnormalities", "Cardiac conduction defects", "Heart conduction disorder" ; a owl:Class ; rdfs:comment "The conduction system of the heart initiates and coordinates the electric signal that causes the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates, this system comprises the sinuatrial (SAN) and atrioventricular nodes (AVN) and the wiring of the ventricles. The latter comprises the atrioventricular bundle (AVB), the left and right bundle branches (BBs), and the peripheral ventricular conduction system (PVCS)." ; rdfs:label "Cardiac conduction abnormality" ; rdfs:subClassOf obo:HP_0030956 . obo:HP_0031547 obo:IAO_0000115 "Any anomaly of the time interval between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG)." ; dc:date "2017-09-24T22:39:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal QT interval" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0031548 obo:IAO_0000115 "A cutaneous adnexal neoplasm with variable clinical presentation. It tends to be located in the head and neck and the presentation is papulonodular, scaly, asymptomatic, measuring up to 1-2cm, simulating a basal cell carcinoma." ; dc:date "2017-09-24T23:07:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basal cell hamartoma with follicular differentiation", "Follicular infundibulum tumour" ; a owl:Class ; rdfs:label "Follicular infundibulum tumor" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0031549 obo:IAO_0000115 "Lymphocytoma cutis, or Spiegler-Fendt sarcoid, is classed as one of the pseudolymphomas, referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Careful clinical evaluation, histopathological and immunohistochemical exams may be needed to make the correct diagnosis." ; dc:date "2017-09-24T23:14:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin pseudolymphoma", "Spiegler-Fendt sarcoid" ; a owl:Class ; rdfs:label "Lymphocytoma cutis" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0031550 obo:IAO_0000115 "Any abnormal result of flow cytometry, a method that suspends cells in a stream of fluid and passes them through an electronic detection apparatus in order to assess cell count or measure biomarkers or surface molecules." ; dc:date "2017-09-24T23:18:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal flow cytometry test result" ; rdfs:subClassOf obo:HP_0025354 . obo:HP_0031551 obo:IAO_0000115 "Reduced level of a protein that is normally present on the cell surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:18:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced cell surface marker level" ; rdfs:subClassOf obo:HP_0031550 . obo:HP_0031552 obo:IAO_0000115 "Reduced level of a protein that is normally present on the fibroblast surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:21:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fibroblast surface marker level" ; rdfs:subClassOf obo:HP_0031551 . obo:HP_0031553 obo:IAO_0000115 "Reduced level of a protein that is normally present on the granulocyte surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:21:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced granulocyte surface marker level" ; rdfs:subClassOf obo:HP_0031551 . obo:HP_0031554 obo:IAO_0000115 "Reduced level of CD55 on the granulocyte surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced granulocyte CD55 level" ; rdfs:subClassOf obo:HP_0031553 . obo:HP_0031555 obo:IAO_0000115 "Reduced level of CD59 on the granulocyte surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced granulocyte CD59 level" ; rdfs:subClassOf obo:HP_0031553 . obo:HP_0031556 obo:IAO_0000115 "Reduced level of CD16 on the granulocyte surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced granulocyte CD16 level" ; rdfs:subClassOf obo:HP_0031553 . obo:HP_0031557 obo:IAO_0000115 "Reduced level of CD55 on the fibroblast surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fibroblast CD55 level" ; rdfs:subClassOf obo:HP_0031552 . obo:HP_0031558 obo:IAO_0000115 "Reduced level of CD59 on the fibroblast surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fibroblast CD59 level" ; rdfs:subClassOf obo:HP_0031552 . obo:HP_0031559 obo:IAO_0000115 "Reduced level of CD16 on the fibroblast surface as assessed by flow cytometry." ; dc:date "2017-09-24T23:23:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fibroblast CD16 level" ; rdfs:subClassOf obo:HP_0031552 . obo:HP_0031560 obo:IAO_0000115 "An abnormal communication between coronary artery and a cardiac chamber." ; dc:date "2017-09-29T11:27:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2233" ; a owl:Class ; rdfs:comment "Coronary cameral fistulas are usually congenital and asymptomatic in majority of patients." ; rdfs:label "Coronary cameral fistula" ; rdfs:subClassOf obo:HP_0011641 . obo:HP_0031561 obo:IAO_0000115 "An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle." ; dc:date "2017-09-29T11:29:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coronary cameral fistula to right ventricle" ; rdfs:subClassOf obo:HP_0031560 . obo:HP_0031562 obo:IAO_0000115 "A type of double aortic arch in which the two branches are of equal size. In most cases of double aortic arch, the right aortic arch is larger and located higher than the left aortic arch." ; dc:date "2017-09-29T11:31:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2780" ; a owl:Class ; rdfs:label "Balanced double aortic arch" ; rdfs:subClassOf obo:HP_0011590 . obo:HP_0031563 obo:IAO_0000115 "An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation." ; dc:date "2017-09-29T12:05:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2240" ; a owl:Class ; rdfs:label "Coronary arteriovenous fistula" ; rdfs:subClassOf obo:HP_0011641 . obo:HP_0031564 obo:IAO_0000115 "An anomalous mirror-imaged arrangement of some bronchial structures. Right isomerism is defined as a subset of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures (vice versa for left isomerism)." ; dc:date "2017-09-29T22:43:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchial isomerism" ; rdfs:subClassOf obo:HP_0031853 . obo:HP_0031565 obo:IAO_0000115 "An abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements." ; dc:date "2017-09-29T22:56:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:3817" ; a owl:Class ; rdfs:label "Abdominal situs ambiguus" ; rdfs:subClassOf obo:HP_0011620 . obo:HP_0031566 obo:IAO_0000115 "Any structural anomaly of the pulmonary valve leaflets." ; dc:date "2017-09-29T23:10:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1652" ; a owl:Class ; rdfs:label "Abnormal pulmonary valve cusp morphology" ; rdfs:subClassOf obo:HP_0001641 . obo:HP_0031567 obo:IAO_0000115 "Any structural anomaly of the aortic valve leaflets." ; dc:date "2017-09-29T23:13:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1480" ; a owl:Class ; rdfs:label "Abnormal aortic valve cusp morphology" ; rdfs:subClassOf obo:HP_0001646 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005990 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031568 obo:IAO_0000115 "An abnormally increased thickness of a leaflet of the aortic valve." ; dc:date "2017-09-29T23:18:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1486" ; a owl:Class ; rdfs:label "Thickened aortic valve cusp" ; rdfs:subClassOf obo:HP_0031567 . obo:HP_0031569 obo:IAO_0000115 "A developmental defect characterized by the lack of aortic valve cusps (leaflets). There may be remnants of the aortic valve in form of a nonobstructive fibrous ridge or rudimentary leaflets or sinuses of Valsalva." ; dc:date "2017-09-29T23:21:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1484" ; oboInOwl:hasExactSynonym "Absent aortic valve" ; a owl:Class ; rdfs:label "Absent aortic valve cusps" ; rdfs:subClassOf obo:HP_0031567 . obo:HP_0031570 obo:IAO_0000115 "A Number 0 Tessier cleft is a true median cleft lip with a broad columella and bifid nasal tip. The alveolar cleft is between the central incisors. The nasal septum may be thickened, duplicated, or absent. The nasal bridge is usually broad with associated orbital hypertelorism. The midline soft tissue anomaly may range from a mild broadening of the philtrum or there may be a true median cleft lip. The columella and nasal tip are typically bifid and broadened with a midline depression. The alae nasi are intact but laterally displaced. The nose appears shortened in the vertical dimension." ; dc:date "2017-10-14T12:22:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tessier facial cleft number 0" ; a owl:Class ; rdfs:label "Tessier number 0 facial cleft" ; rdfs:subClassOf obo:HP_0100629 . obo:HP_0031571 obo:IAO_0000115 "A type of facial cleft located near to but not directly on the midline of the face." ; dc:date "2017-10-14T12:27:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paramedian facial cleft" ; rdfs:subClassOf obo:HP_0002006 . obo:HP_0031572 obo:IAO_0000115 "As seen in a typical cleft lip, a cleft of the lip is found in the region of the cupid's bow. The nostril is cleft through the alar dome and extends above onto the nasal dorsum. It passes medial to a normal, but dys- topic, medial canthus. There is an alveolar cleft between the central and lateral incisors that extends above through the pyriform margin lateral to the anterior nasal spine; the nasal septum is not involved. The bony cleft extends through the nasal bone or between the junction of the nasal bone and frontal process of the maxilla. Above the cleft lip, the clefting of the alar dome is associated with deviation to the opposite side of the shortened and broadened columella and nasal tip. Extension of the soft tissue cleft onto the nasal dorsum can be manifest as a series of vertical soft tissue furrows and ridges. Vertical inner canthal dysto- pia and severe telecanthus mark the superior aspect of the Number 1 facial cleft. A cranial soft tissue extension characterized by a tongue-like projection of the frontal hairline delineates the number 13 cleft. Skeletal clefting of the maxilla may extend posteriorly to form a complete cleft of the hard and soft palate. The maxilla is hypoplastic in all three dimensions. There is a keel-shaped alveolus and anterior open bite. Normal septation is preserved between the nasal cavity and the hypoplastic maxillary antrum on the affected side. Distortion of the nasal skeleton produces gross flattening of the nasal dorsum. There is asymmetry of the pterygoid plates, of the greater and lesser wings of the sphenoid, and of the floor of the anterior cranial fossa. The distortion of the cranial base may result in a mild plagiocephaly." ; dc:date "2017-10-14T12:27:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 1 facial cleft" ; rdfs:subClassOf obo:HP_0031571 . obo:HP_0031573 obo:IAO_0000115 "As is typically seen in isolated cleft cases, a cleft of the lip is present. There is hypoplasia, but not true notching of the ala nasi with flattening of the lateral part of the nose. The nasal root is broadened, with lateral displacement of the inner canthus. The palpebral fissure and lacrimal drainage system are not disturbed. The alveolar cleft is through the lateral incisor area and extends to the pyriform aperture. There is normal septation between the nasal cavity and maxillary sinus. Notching at the junction between the nasal bone is present, as is a broad, flat frontal process of the maxilla. Transverse ethmoid enlargement produces orbital hypertelorism. Above the cleft of the lip and palate is a true broad cleft of the nostril that is medial to the intact, but laterally displaced, tail of the alar cartilage. A shallow soft tissue groove extends superiorly to the asymmetrically widened nasal root. The lacrimal system, palpebral fissures, and eyebrows remain intact. The alveolar cleft extends posteriorly as a complete unilateral cleft of the hard and soft palate. The nasal septum is intact but deviated to the opposite side. The nasal cavity remains separated from the normally pneumatized, although hypoplastic, maxilla on the cleft side. Above the nasomaxillary notching, the ethmoid sinus is less well developed, and there is no pneumatization of the frontal sinus on this side. Anterior rotation of the greater and lesser wings of the sphenoid occurs on the cleft side in relation to the narrower orbit and smaller ethmoid sinus. There is mild asymmetry of the anterior cranial fossa, which is narrower on the cleft side. The cranium is brachycephalic with marked occipital flattening." ; dc:date "2017-10-14T12:36:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 2 facial cleft" ; rdfs:subClassOf obo:HP_0031571 . obo:HP_0031574 obo:IAO_0000115 "A facial cleft characterized by involvement of the orbit." ; dc:date "2017-10-14T12:37:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orbital cleft" ; rdfs:subClassOf obo:HP_0002006 . obo:HP_0031575 obo:IAO_0000115 "As in the Number 1 and Number 2 clefts, this cleft extends through the lip in the region of the typical cleft lip; however, it does not extend through the base. The cleft continues superiorly to involve the inner canthus and lower eyelid medial to the inferior lacrimal punctum, thereby disrupting the nasolacrimal system. Microphthalmia may be present. The alveolar cleft is between the lateral incisor and the canine. Absent septation between the nasal cavity and maxillary antrum, together with the distortion of the frontal process of the maxilla and lacrimal fossa, produces direct communication between the orbit, maxillary sinus, and nose. There is hypoplasia of the soft tissue margins of the cleft in the vertical dimension. This produces extreme soft tissue deficiency between the alar base and the cleft of the medial aspect of the lower eyelid. The inferior lacrimal punctum is evident at the lateral margin of the lower eyelid cleft. The lacrimal drainage system ends as an opening directly onto the cheek without communication into the nasal cavity. The globe is normal in size, but it is displaced inferiorly and laterally. The nasal septum shows the characteristic distortion seen in typical cleft lip and palate. There is absence of septation between the nasal cavity on the cleft side and the maxilla. The maxilla is hypoplastic in three dimensions, with a marked reduction in pneumatization. Superior extension of the skeletal clefting into the medial portion of the orbital floor and into the inferior orbital rim in the region of the frontal process of the maxilla allows direct communication between the orbit above and the nasomaxillary region below. There is mild narrowing of the ethmoid sinus and of the body of the sphenoid on the cleft side. The pterygoid process appears anatomically normal, but less displaced from the midline compared with that of the noncleft side. Both the orbit and the floor of the anterior cranial fossa are inferiorly displaced." ; dc:date "2017-10-14T12:38:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 3 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031576 obo:IAO_0000115 "The cleft lip is midway between the philtral ridge and the commissure of the mouth. The cleft is lateral to the normally shaped and placed nasal ala and passes onto the cheek. The cleft extends through the lower eyelid lateral to the punctum. The lacrimal system and inner canthus are normal. Microphthalmia may be present. The alveolar cleft passes between the lateral incisor and canine, as in the Number 3 cleft. The cleft passes around the pyriform aperture and continues through the portion of the maxillary sinus medial to the infraorbital foramen. The cleft terminates at the medial end of the inferior orbital rim. There is severe vertical soft tissue deficiency in a Number 4 cleft, with the medial margins of the cleft lip extending directly into the medially placed cleft of the lower eyelid. Within the medial segment of the right-sided cleft lip, muscle elements are apparently absent. Muscle bunching is noted in the ipsilateral lateral lip segment, as is seen in a typical unilateral cleft lip. The anatomically normal nasal ala is superiorly displaced in association with a severe deficiency in the overall nasal length. Marked dystopia of the right globe results in its inferior displacement into the medially deficient orbital floor and inferior rim. Both globes are otherwise normal. The complete palatal cleft passes through the maxilla medial to the infraorbital foramen and extends to the medial portion of the inferior orbital rim without evidence of an intact maxillary sinus. Bony septation persists medially, thereby separating the nasal cavity from the orbit, maxillary sinus, and mouth, which are contiguous. Marked midfacial hypoplasia is present. The cleft is manifest as asymmetry of the body of the sphenoid; it is smaller on the right, with asymmetric placement of the pterygoid plates relative to the midline. The orbital floor cleft has no communication with the inferior orbital fissure. The cleft does not extend to the skull base, but there is marked facial asymmetry associated with plagiocephaly." ; dc:date "2017-10-14T12:40:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 4 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031577 obo:IAO_0000115 "The cleft of the lip is just medial to the oral commissure and extends across the cheek as a furrow. It ends as a cleft at the junction of the middle and lateral third of the lower eyelid. Microphthalmia is frequently present. The alveolar cleft is through the premolar region and extends superiorly through the orbit at the inferolateral part of the rim and floor. There is a vertical soft tissue deficiency between the lateral portion of the lip and the lower eyelid cleft. The left side of the nose shows vertical shortening, and the left alar base is displaced superiorly. Facial asymmetry secondary to the skeletal abnormality is reflected by a vertical orbital dystopia. However, bothglobes are normal, and there is no abnormality of the upper eyelids, eyebrow, forehead, or frontal hairline. The skeletal clefts vary, ranging from a narrow skeletal furrow that traverses the anterior maxillary wall as on the rightto a broad cleft of the maxilla lateral to the infraorbital foramen and maxillary sinus. This latter cleft enters the inferolateral orbital rim and floor without posterior communication with the inferior orbital fissure on the left side. Medial collapse of the lateral maxillary segments is present bilaterally, with reduction in the transverse dimensions of the maxillary arch. Manifestations of the skeletal disturbance in the sphenoid include a shortening and thickening of the lateral orbital walls in the region of the greater wing and mild asymmetric placement of the pterygoid plates relative to the midline. The right-sided pterygoid plates are smaller and closer to the midline. There is minimal asymmetry of the cranial base and calvarium." ; dc:date "2017-10-14T12:42:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 5 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031578 obo:IAO_0000115 "A facial cleft extending from the zygomatic arch to the eye. This zygomaticomaxillary cleft is similar to that typically found in Treacher Collins syndrome. The overlying tissue shows a vertical sclerodermic furrow radiating from the labial commissure or the angle of the mandible across the cheek to a coloboma of the lower eyelid between the middle and lateral one-third. Microphthalmia is not observed. The skeletal cleft is between the maxilla and zygoma; it passes through the inferolateral orbital rim to enter the inferior orbital fissure. No alveolar cleft is present. The zygomatic arch is intact. The soft tissue furrow, which is more apparent on the right, radiates from the oral commissure toward the lateral two-thirds of the lower eyelid. The antimongoloid obliquity of the palpebral fissures is associated with laterally placed lower eyelid clefts and some ectropion. A left-sided anophthalmia is accompanied by adjacent soft tissue hypoplasia and is reflected in a short palpebral fissure, enophthalmos, and minor ptosis of the eyebrow. No abnormality is present in the alveolar arch except for some tilting of the occlusal plane secondary to hypoplasia of the left side of the maxilla. There is a vertical bony groove in the region of the zygomaticomaxillary suture that ends in the inferolateral portion of a small bony orbit. More laterally, the remainder of the zygomatic body and arch is normal in both shape and dimension. The lateral orbital floor is downslanting but intact, and it lacks direct communication with the temporal or infratemporal fossae. The hypoplasia of the left side of the maxilla and orbit is associated with a reduction in the transverse and anteroposterior dimensions of the anterior cranial fossa; mild asymmetry of the middle cranial fossa and calvarium is present. No significant asymmetry of size, shape, or position is present in the sphenoid." ; dc:date "2017-10-14T12:43:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tessier facial cleft number 6" ; a owl:Class ; rdfs:label "Tessier number 6 facial cleft" ; rdfs:subClassOf obo:HP_0100731 . obo:HP_0031579 obo:IAO_0000115 "The temporozygomatic Number 7 cleft is found in both Treacher Collins syndrome and hemifacial microsomia. Soft tissue manifestations include macrostomia, malformations of the external and middle ear, temporalis muscle, variable involvement of the seventh cranial nerve (in hemifacial microsomia), and abnormalities of the preauricular hair in Treacher Collins syndrome. The skeletal cleft is through the pterygomaxillary junction, and vertical maxillary hypoplasia is present. In addition, abnormality of the mandibular ramus, coronoid, and condyle and absence of the zygomatic arch are typically present. A soft tissue furrow extends from the macrostomia laterally and superiorly across the cheek toward the preauricular hairline. The lower eyelids are intact. The anatomy of the external ear is normal, and there are no preauricular tags. Bony clefting is through the pterygomaxillary junction with hypoplasia of the alveolar process in the molar region, thereby producing a posterior open bite. The maxilla is hypoplastic, although the maxillary sinuses are symmetrically pneumatized. The hypoplastic zygomatic body arches upward, but then it takes a downward course and is severely malformed and displaced. The zygoma is continuous posteriorly with an apparently normal zygomatic process of the temporal bone. The mandibular condyle and coronoid process are hypoplastic and asymmetric. There is no antegonial notching of the mandible. Marked cranial base asymmetry, with tilting and asymmetric positioning of the temporomandibular articulations, is present. The anatomy of the sphenoid is abnormal, especially on the right where there is no recognizable medial or lateral pterygoid plate." ; dc:date "2017-10-14T12:45:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tessier cleft number 7", "Tessier facial cleft number 7" ; a owl:Class ; rdfs:label "Tessier number 7 facial cleft" ; rdfs:subClassOf obo:HP_0100731 . obo:HP_0031580 obo:IAO_0000115 "The frontozygomatic or Number 8 cleft is found in both Treacher Collins syndrome and the Goldenhar variant of hemifacial microsomia. Skeletal defects are more prominent in Treacher Collins syndrome, whereas the soft tissue clefting is more typical in cases of ''Goldenhar syndrome''. Soft tissue clefting presents as a dermatocele, a true lateral eyelid coloboma with absence of the outer canthus, and anomalies of the globe itself, especially epibulbar cysts in patients with Goldenhar syndrome. The frontozygomatic bony cleft produces absence of the lateral orbital rim; this border now is formed by the hypoplastic greater wing of the sphenoid. The absence of bony support for the outer canthus produces lateral canthal dystopia and the characteristic antimongoloid slant of the palpebral fissures. Secondary to the bony deficiency in the lateral orbital wall and floor, there is soft tissue continuity between the orbit, temporal fossa, and infratemporal region. Preauricular hairline indicators delineate the Number 8 cleft as the first of the northbound clefts. Complete absence of the bony lateral orbital wall and rim constitute the skeletal element of the Number 8 cleft. The lateral border of the orbit is formed by the greater wing of the sphenoid from which small spicules of bone, which represent the rudimentary zygoma, may be found in Treacher Collins syndrome. The symmetry of the facial anomalies is reflected in the apparently normal symmetric anterior and middle cranial fossae." ; dc:date "2017-10-14T12:46:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tessier facial cleft number 8" ; a owl:Class ; rdfs:label "Tessier number 8 facial cleft" ; rdfs:subClassOf obo:HP_0100731 . obo:HP_0031581 obo:IAO_0000115 "This is an upper lateral orbital cleft. The soft tissue deformity is in the lateral one-third of the upper eyelid, and the bony cleft is through the superolateral orbital angle. Microphthalmia is present. The superolateral bony deficiency of the orbits allows a lateral displacement of the globes. The lateral one-third of the upper eyelid and the outer canthus are distorted, thus preventing apposition to the globe. The upper eyelid does not have a true cleft. A soft tissue furrow radiates superiorly and posterisphenoid is symmetric and normal. Mild cranial base asymmetry is reflected in the pterygoid plates. The left pair is more laterally displaced from the midline. Skull vault plagiocephaly is evident with an apparent reduction in the anteroposterior dimension of the anterior cranial fossa." ; dc:date "2017-10-14T12:48:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 9 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031582 obo:IAO_0000115 "In a Number 10 Tessier cleft there is an upper central orbital cleft with a cleft of the middle one-third of the upper eyelid, which often results in total ablepharia. The eyebrow is disrupted, being virtually absent medially, whereas the lateral portion angles upward toward the frontal hairline. There may be ocular anomalies, including colobomata of the iris. The skeletal cleft is through the midportion of the supraorbital rim, the adjacent frontal bone, and the orbital roof lateral to the supraorbital nerve. A frontal encephalocele frequently occupies the frontal bony cleft. The palpebral fissure is grossly elongated with an amblyopic eye displaced inferiorly and laterally. There is also a divergent squint of the right eye. The eyebrow is deficient medially and becomes thinned out laterally , where it is contiguous with a broad downward and forward projection of the frontotemporal hairline (this may be seen in both the Number 9 and 10 clefts.) A broad frontal encephalocele bulges forward from the middle one-third of the right forehead, supraorbital ridge, and orbital roof. The bony cleft, through which the frontal encephalocele presents, involves the anterior half of the orbital roof, the supraorbital rim, and two-thirds of the vertical height of the frontal bone lateral to the supraorbital nerve. The bony orbit is inferiorly displaced and widened with the lateral orbital wall shortened and laterally deviated. Similar distortion of the anterior cranial fossa is evident, being broader and more flattened on the affected side. The calvarium above the level of the cleft and the cranial base below is symmetric." ; dc:date "2017-10-14T12:49:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 10 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031583 obo:IAO_0000115 "An upper medial orbital cleft produces a cleft of the medial one-third of the upper eyelid that extends through the eyebrow into the frontal hairline. The skeletal element of the cleft in the region of the frontal process of the maxilla may either pass lateral to the ethmoid, through the supraorbital rim, or it may pass through the ethmoidal labyrinth to produce orbital hypertelorism. This cleft usually accompanies the Number 3 cleft. The soft tissue features include a cleft of the medial portion of the upper eyelid, an irregularity in hair orientation at the medial end of the eyebrow, and a long tongue-like projection of the frontal hairline onto the forehead. There is a mild flattening of the frontal process of the maxilla and extensive pneumatization of both the ethmoidal and frontal sinuses, both of which are more prominent on the cleft side. No bony clefting of the supraorbital rim or frontal bone is evident. The cranial base and sphenoid architecture, including the pterygoid processes, are symmetric and normal." ; dc:date "2017-10-14T12:51:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 11 facial cleft" ; rdfs:subClassOf obo:HP_0031574 . obo:HP_0031584 obo:IAO_0000115 "There is a soft tissue cleft medial to the inner canthus with a cleft of the root of the eyebrow. The frontal process of the maxilla is flat and broadened, and the ethmoid labyrinth is increased in tranverse dimension, thereby producing orbital hypertelorism. The cribriform plate is of normal width. The frontal sinus is enlarged. Even though the frontal bone is flattened, bony clefts with encephalocele have not been observed. There is a lateral displacement of the inner canthus with a mild thinning, aplasia, or irregularity of the medial end of the eyebrow. There are no eyelid clefts. The soft tissue contour of the forehead is normal, with only a short downward prolongation of the paramedian frontal hairline to mark the superior extent of the soft tissue cleft. Flattening of the frontal process of the maxilla, an increase in the transverse dimension of the ethmoid sinus, and a laterally convex bowing of the medial orbital wall produce orbital hypertelorism. Superiorly there is a minor flattening of the frontal bone medially, and the nasofrontal angle is somewhat obtuse. The extensive pneumatization of the sinuses on the cleft side extends backward through the frontal and ethmoid sinuses and into the sphenoid sinus. The anatomy of the sphenoid, including the pterygoid processes, is otherwise normal. The anterior and middle cranial fossae floors are both broadened on the cleft side with minor widening of the cribriform plate." ; dc:date "2017-10-14T12:52:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 12 facial cleft" ; rdfs:subClassOf obo:HP_0031571 . obo:HP_0031585 obo:IAO_0000115 "There is a paramedian frontal encephalocele and a soft tissue cleft that passes medial to an intact eyebrow. The frontal bone shows a paramedian bony cleft with an associated encephalocele. The olfactory groove, cribriform plate, and ethmoid sinus are all increased in transverse diameter, resulting in hypertelorism. The cleft extends medially to the undisturbed eyebrow to end in a short paramedian frontal widow's peak. The bony cleft begins in the region of the nasal bone and extends superiorly through the full height of the frontal bone. Posteriorly, the cleft extends through the cribriform plate and ethmoid sinus as far as the lesser wing and body of the sphenoid. The pterygoid processes are anatomically normal, but they are displaced laterally from the midline on the cleft side. There is orbital hypertelorism below and asymmetry of the floor of the anterior cranial fossa above." ; dc:date "2017-10-14T12:54:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 13 facial cleft" ; rdfs:subClassOf obo:HP_0031571 . obo:HP_0031586 obo:IAO_0000115 "This midline cranial cleft usually occurs with a midline facial cleft that completes a median craniofacial dysraphia. A broad nasal root and bifid nose are associated with orbital hypertelorism and a median frontal encephalocele. The frontal bone abnormality varies from a minor flattening to a large midline defect. There is an increased distance between the olfactory grooves. The crista galli is widened, duplicated, or in some cases absent. Marked inferior prolapse of the enlarged ethmoid bone occurs with orbital hypertelorism. The severe orbital hypertelorism is associated with a broad flattening of the glabella and extreme lateral displacement of the inner canthi. The periorbita, including the eyelids and eyebrows, are otherwise normal. A long midline projection of the frontal hairline marks the superior extent of the soft tissue features of this midline cranial cleft. The median frontal defect delineates the region through which the frontal encephalocele herniates. The lateral segments of the frontal bone sweep upward from the region of the intact glabella and are flattened laterally. No pneumatization of the frontal sinus is evident. The crista galli and the perpendicular plate of the ethmoid are bifid. Just as the ethmoid, including the cribriform plate, is widened and caudally displaced, the sphenoid sinus is broadened and extensively, but symmetrically pneumatized. The lateral rotation of the greater and lesser wings of the sphenoid results in a relative shortening of the anteroposterior dimension of the middle cranial fossa. The floor of the anterior cranial fossa is upslanting from its medial aspect to its lateral aspect, with a harlequin appearance on the coronal scan." ; dc:date "2017-10-14T12:56:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tessier facial cleft number 14" ; a owl:Class ; rdfs:label "Tessier number 14 facial cleft" ; rdfs:subClassOf obo:HP_0100629 . obo:HP_0031587 obo:IAO_0000115 "A lower midline facial cleft, also known as the median mandibular cleft. It is a rare anomaly, which may be limited to a defect in the soft tissue of the lower lip. However, in the more severe form, it may extend into the bony mandibular symphysis." ; dc:date "2017-10-14T12:58:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tessier number 30 facial cleft" ; rdfs:subClassOf obo:HP_0100629 . obo:HP_0031588 obo:IAO_0000115 "A conspicuously unhappy disposition characterized by negative assumptions, self-defeating talk, fear of failure, and negative ruminations about past events." ; dc:date "2017-10-14T13:22:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Unhappy demeanour" ; a owl:Class ; rdfs:label "Unhappy demeanor" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0031589 obo:IAO_0000115 "Frequent thinking about or preoccupation with killing oneself." ; dc:date "2017-10-14T13:24:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Suicidality" ; a owl:Class ; rdfs:label "Suicidal ideation" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0031590 obo:IAO_0000115 "Eye strain, i.e., a feeling of fatigue or discomfort of the eyes related to 'overuse' of the eyes in activities such as reading or working at the computer and often accompanied by lacrimation or headache." ; dc:date "2017-10-14T13:28:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eye strain" ; a owl:Class ; rdfs:label "Asthenopia" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0031591 obo:IAO_0000115 "An abnormally large Eustachian valve (postnatally). The Eustachian valve is also known as the valve of the inferior vena cava, and is an embryologic remnant of the valve of the inferior vena cava." ; dc:date "2017-10-15T12:51:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Enlarged inferior vena cava valve" ; oboInOwl:hasNarrowSynonym "Giant Eustachian valve" ; a owl:Class ; rdfs:comment "During fetal life, the eustachian valve directs oxygen-rich blood from the inferior vena cava (IVC) toward the foramen ovale and away from the tricuspid valve. After the closure of the foramen ovale, it does not have a specific function. In echocardiographic examinations, the eustachian valve may appear as a thin flap originating from the orifice of the IVC, or it may be totally absent. Sometimes it may appear as a rigid, elongated structure in the inferior portion of the right atrium or as a membranous, undulating, echogenic mass within the right atrial cavity." ; rdfs:label "Enlarged Eustachian valve" ; rdfs:subClassOf obo:HP_0025576 . obo:HP_0031592 obo:IAO_0000115 "Situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia." ; dc:date "2017-10-15T13:19:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Situs inversus with levocardia" ; rdfs:subClassOf obo:HP_0011534 . obo:HP_0031593 obo:IAO_0000115 "An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds." ; dc:date "2017-10-15T13:27:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The PR interval begins at the onset of the P wave and ends at the onset of the QRS complex. This interval reflects the time the impulse takes to reach the ventricles from the sinus node. In contrast, the PR segment begins at the endpoint of the P wave and ends at the onset of the QRS complex. It reflects the conduction from the atrioventricular node, down the bundle of His and through the bundle branches to the muscle." ; rdfs:label "Abnormal PR interval" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0031594 obo:IAO_0000115 "A reduction in voltage of the PR segment below baseline." ; dc:date "2017-10-15T13:31:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "PR interval depression", "PTa depression" ; a owl:Class ; rdfs:comment "The differential diagnosis includes normal variant, pericarditis or atrial infarct." ; rdfs:label "PR segment depression" ; rdfs:subClassOf obo:HP_0031596 . obo:HP_0031595 obo:IAO_0000115 "Any anomaly of the P wave of the EKG, which results from atrial depolarization. The P wave occurs when the sinoatrial node creates an action potential that depolarizes the atria." ; dc:date "2017-10-15T13:31:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "P waves are normally upright in leads I and II and inverted in aVR." ; rdfs:label "Abnormal P wave" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0031596 obo:IAO_0000115 "An anomaly of the PR segment, which begins at the endpoint of the P wave and ends at the onset of the QRS complex. The PR segment is normally flat and isoelectric." ; dc:date "2017-10-15T13:35:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The PR interval begins at the onset of the P wave and ends at the onset of the QRS complex. This interval reflects the time the impulse takes to reach the ventricles from the sinus node. In contrast, the PR segment begins at the endpoint of the P wave and ends at the onset of the QRS complex. It reflects the conduction from the atrioventricular node, down the bundle of His and through the bundle branches to the muscle." ; rdfs:label "Abnormal PR segment" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0031597 obo:IAO_0000115 "An increase in voltage of the PR segment above baseline." ; dc:date "2017-10-15T13:45:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "PR interval elevation", "PTa elevation" ; a owl:Class ; rdfs:label "PR segment elevation" ; rdfs:subClassOf obo:HP_0031596 . obo:HP_0031598 obo:IAO_0000115 "V-shaped cut (notch) in the middle of the P wave." ; dc:date "2017-10-15T13:53:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "One may observe notched P-waves in the frontal plane in partial interatrial block." ; rdfs:label "Notched P wave" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0031599 obo:IAO_0000115 "A broad (120 ms or longer in duration) and bifid P-wave in EKG lead II." ; dc:date "2017-10-15T14:01:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "P mitrale" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0031600 obo:IAO_0000115 "P wave below instead of above the baseline. P-wave inversion in the inferior leads may indicate a non-sinus origin of the P waves." ; dc:date "2017-10-15T14:02:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "P wave inversion" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0031601 obo:IAO_0000115 "The presence of tall, peaked P waves in EKG lead II." ; dc:date "2017-10-15T14:02:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "P pulomonale may indicate right atrial enlargement, usually due to pulmonary hypertension." ; rdfs:label "P pulmonale" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0031602 obo:IAO_0000115 """An anomaly in the system of mucociliary transport, which functions to transport the mucous layer lining the respiratory epithelium by ciliary beating.""" ; dc:date "2017-10-22T12:41:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal mucociliary transport" ; a owl:Class ; rdfs:label "Abnormal mucociliary clearance" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0031603 obo:IAO_0000115 "An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components: physicochemical qualities and quantities of mucus and the properties of cilia that propel it. NMC is considered to be representative of pulmonary clearance. normal NMC time is determined to be up to 20 minutes. Duration of 30 minutes is considered as the cutoff point that discriminates normal subjects from subjects with impaired NMC. NMC can be measured by determination of the transport time of markers that are placed on the nasal mucosa including saccharine, radioactive markers, and dyes." ; dc:date "2017-10-22T12:44:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasNarrowSynonym "Abnormal saccharine test" ; a owl:Class ; rdfs:label "Impaired nasal mucociliary clearance" ; rdfs:subClassOf obo:HP_0031602 . obo:HP_0031604 obo:IAO_0000115 "A developmental defect characterized by the lack of formation of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse." ; dc:date "2017-10-22T13:26:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bony carotid canal agenesis" ; a owl:Class ; rdfs:comment "This abnormally is associated with Internal carotid artery (ICA) agenesis, since the ICA normally enters the skull through the carotid canal." ; rdfs:label "Agenesis of the carotid canal" ; rdfs:subClassOf obo:HP_0009911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006668 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031605 obo:IAO_0000115 "Any anomaly of the pigmentation of the fundus, the posterior part of the eye including the retina and optic nerve." ; dc:date "2017-12-01T11:02:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Alterations in pigmentation of the fundus are typically not a result of changes in the retina. The variable pigmentation within both RPE and choroid combine to change profoundly the appearance of the normal fundus between individuals. This is partly a racial characteristic and partly genetic." ; rdfs:label "Abnormality of fundus pigmentation" ; rdfs:subClassOf obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003951 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031606 obo:IAO_0000115 "Fluffy white patch on the retina, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels." ; dc:date "2017-12-02T11:22:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Retinal cotton wool spot" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0031607 obo:IAO_0000115 "Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position." ; dc:date "2017-12-09T14:09:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pelvic organ prolapse" ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0031609 obo:IAO_0000115 "Sharply demarcated area of partial or complete depigmentation of the fundus reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss. The margins of the de-pigmented area are usually scalloped and the large choroidal vessels are visible through the atrophic retinal pigment epithelium." ; dc:date "2017-12-10T14:57:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Geographic atrophy" ; rdfs:subClassOf obo:HP_0001105 . obo:HP_0031610 obo:IAO_0000115 "Shoulder dislocation occurring repeated times." ; dc:date "2017-12-11T10:45:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multiple shoulder dislocation" ; a owl:Class ; rdfs:label "Recurrent shoulder dislocation" ; rdfs:subClassOf obo:HP_0003834, obo:HP_0031869 . obo:HP_0031611 obo:IAO_0000115 "A type of intraretinal hemorrhage that is located in the superficial retina between the inner limiting membrane and the retinal nerve fiber layer." ; dc:date "2017-12-16T12:30:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sub-ILM haemorrhage", "Sub-ILM hemorrhage", "Sub-inner limiting membrane haemorrhage" ; a owl:Class ; rdfs:comment "Preretinal hemorrhages usually occur at the interface between the posterior hyaloid and inner limiting membrane (ILM). Less frequently, they are located in the superficial retina between the ILM and the retinal nerve fibre layer. These sharply demarcated, dome-shaped hemorrhages show a predilection for the macular region and consequently lead to severe visual impairment." ; rdfs:label "Sub-inner limiting membrane hemorrhage" ; rdfs:subClassOf obo:HP_0000573 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001794 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031613 obo:IAO_0000115 "Absence of a region of the retina, retinal pigment epithelium, and choroid at the lower part of the fundus." ; dc:date "2017-12-16T12:49:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior chorioretinal coloboma" ; rdfs:subClassOf obo:HP_0000567 . obo:HP_0031614 obo:IAO_0000115 "A notch or cleft of the lower part of the retina." ; dc:date "2017-12-16T12:58:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior retinal coloboma" ; rdfs:subClassOf obo:HP_0000480 . obo:HP_0031615 obo:IAO_0000115 "Presence of pus (appears as a white fluid) producing a fluid level in the inferior part of the anterior chamber." ; dc:date "2017-12-16T13:13:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypopyon" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0031616 obo:IAO_0000115 "An abnormal appearance of the beam of light traveling through the anterior chamber of the eye in a slit lamp examination. The flare is produced by an increased concentration of proteins in the aqueous humor in the anterior chamber." ; dc:date "2017-12-16T13:18:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anterior chamber flare grade 0 (i.e., a normal finding) should be coded as the negation of this term." ; rdfs:label "Anterior chamber flare" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0031618 obo:IAO_0000115 "Faint anterior chamber flare." ; dc:date "2017-12-16T13:29:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber flare grade 1+" ; rdfs:subClassOf obo:HP_0031616 . obo:HP_0031619 obo:IAO_0000115 "Moderate anterior chamber flare (iris and lens details clear)." ; dc:date "2017-12-16T13:29:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber flare grade 2+" ; rdfs:subClassOf obo:HP_0031616 . obo:HP_0031620 obo:IAO_0000115 "Marked anterior chamber flare (iris and lens details hazy)." ; dc:date "2017-12-16T13:31:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber flare grade 3+" ; rdfs:subClassOf obo:HP_0031616 . obo:HP_0031621 obo:IAO_0000115 "Intense anterior chamber flare (fibrin/plastic aqueous)." ; dc:date "2017-12-16T13:32:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior chamber flare grade 4+" ; rdfs:subClassOf obo:HP_0031616 . obo:HP_0031622 obo:IAO_0000115 "An ocular motility defect where the affected eye(s) does not elevate in adduction but has full depression in adduction. It can be congenital or acquired from injury to or defect of the superior oblique tendon or trochlea and has a positive forced duction test result." ; dc:date "2017-12-16T13:37:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Brown syndrome" ; a owl:Class ; rdfs:label "Brown anomaly" ; rdfs:subClassOf obo:HP_0025068 . obo:HP_0031623 obo:IAO_0000115 "Drooping of the upper eyebrow below the superior orbital rim." ; dc:date "2017-12-16T13:48:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Drooping brow" ; a owl:Class ; rdfs:comment "Eybrow ptosis can be caused by age-related changes in the periorbital soft tissues and soft tissues of the face." ; rdfs:label "Brow ptosis" ; rdfs:subClassOf obo:HP_0000534 . obo:HP_0031624 obo:IAO_0000115 "A moderate form of myopia with refractive error of between -3.00 and -6.00 diopters." ; dc:date "2017-12-16T14:07:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Moderate myopia" ; rdfs:subClassOf obo:HP_0000545 . obo:HP_0031625 obo:IAO_0000115 "A contained rupture of an artery with a disruption in all 3 layers of the arterial wall." ; dc:date "2017-12-16T15:55:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pseudoaneurysms may occur under 4 circumstances: (1) after catheterization; (2) at the site of native artery and synthetic graft anastomosis (eg, aortofemoral bypass graft); (3) trauma; and (4) infection (eg, mycotic PSA)." ; rdfs:label "Pseudoaneurysm" ; rdfs:subClassOf obo:HP_0002617 . obo:HP_0031626 obo:IAO_0000115 "Absence of the normal opening of a coronary ostium. There are normally two coronary ostia, which are site of origin of the main left or right main coronary artery and are located in the ascending aorta just above the aortic valve." ; dc:date "2017-12-16T16:26:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atresia of coronary ostium" ; a owl:Class ; rdfs:comment "Coronary ostial atresia is usually associated with ischemic manifestations" ; rdfs:label "Coronary ostial atresia" ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0031627 obo:IAO_0000115 "Pathological deposition of calcium salts in the globus pallidus." ; dc:date "2017-12-17T00:15:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Globus pallidus calcification" ; rdfs:subClassOf obo:HP_0002453 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001875 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031628 obo:IAO_0000115 "Cardiac arrest that would have led to rapid and unexpected death had an intervention not taken place to prevent it." ; dc:date "2017-12-17T00:22:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sudden cardiac arrest" ; a owl:Class ; rdfs:label "Aborted sudden cardiac death" ; rdfs:subClassOf obo:HP_0001695 . obo:HP_0031629 obo:IAO_0000115 "Reduced ability to walk in a straight line while placing the feet heel to toe." ; dc:date "2017-12-17T00:38:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clumsy tandem walking" ; a owl:Class ; rdfs:label "Impaired tandem gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031630 obo:IAO_0000115 "Any structural anomaly located between the pleura and the chest wall." ; dc:date "2017-12-17T00:44:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal subpleural morphology" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0031631 obo:IAO_0000115 "So-called honeycombs (variably sized cysts in a background of densely scarred tissue) located in the subpleural space." ; dc:date "2017-12-17T00:47:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pathologically, honeycombing represents destroyed and fibrotic lung tissue that contains numerous cystic airspaces with thick fibrous walls." ; rdfs:label "Subpleural honeycombing" ; rdfs:subClassOf obo:HP_0031630 . obo:HP_0031632 obo:IAO_0000115 "Abnormal origin of the right subclavian artery from the descending aorta. The right subclavian artery normally arises from the brachiocephalic trunk, which divides into the right common carotid artery and right subclavian artery." ; dc:date "2017-12-17T01:01:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of the right subclavian artery from the descending aorta" ; rdfs:subClassOf obo:HP_0031251 . obo:HP_0031633 obo:IAO_0000115 "The loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus." ; dc:date "2017-12-17T01:04:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2732" ; a owl:Class ; rdfs:label "Isolation of the left subclavian artery" ; rdfs:subClassOf obo:HP_0031251 . obo:HP_0031634 obo:IAO_0000115 "The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the main pulmonary artery." ; dc:date "2017-12-17T12:26:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of the left common carotid artery from the main pulmonary artery" ; rdfs:subClassOf obo:HP_0430021 . obo:HP_0031635 obo:IAO_0000115 "The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the brachiocephalic artery." ; dc:date "2017-12-17T12:29:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anomalous origin of the left common carotid artery from the brachiocephalic trunk" ; a owl:Class ; rdfs:label "Anomalous origin of the left common carotid artery from the brachiocephalic artery" ; rdfs:subClassOf obo:HP_0430021 . obo:HP_0031636 obo:IAO_0000115 "The right common carotid artery normally originates from the brachiocephalic artery. This term refers to an origin of this artery directly from the aorta." ; dc:date "2017-12-17T12:31:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous origin of the right common carotid artery from the aorta" ; rdfs:subClassOf obo:HP_0430021 . obo:HP_0031637 obo:IAO_0000115 "Absence of the normal opening of the coronary ostium from which the right main coronary artery originates." ; dc:date "2017-12-17T12:45:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Right coronary artery ostial atresia" ; rdfs:subClassOf obo:HP_0031626 . obo:HP_0031638 obo:IAO_0000115 "The left anterior descending artery (LAD) branches off from the pulmonary artery." ; dc:date "2017-12-17T12:50:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Normally the left main coronary artery bifurcates into the left circumflex artery and the LAD." ; rdfs:label "Anomalous origin of the left anterior descending artery from the pulmonary artery" ; rdfs:subClassOf obo:HP_0011637 . obo:HP_0031639 obo:IAO_0000115 "The left main coronary artery (LMCA) is absent and the left anterior descending (LAD) and left circumflex (LCX) arteries arise from separate but adjacent ostia in the left sinus of Valsava." ; dc:date "2017-12-17T12:56:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent LMCA" ; a owl:Class ; rdfs:label "Absent left main coronary artery" ; rdfs:subClassOf obo:HP_0011636 . obo:HP_0031640 obo:IAO_0000115 "Any structural anomaly of the radial artery." ; dc:date "2017-12-17T13:30:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal radial artery morphology" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0031643 obo:IAO_0000115 "A concentric abnormal localized widening (dilatation) of the ascending tubular aorta that involves the full circumference of the vessel wall." ; dc:date "2017-12-17T14:02:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fusiform ascending tubular aorta aneurysm" ; rdfs:subClassOf obo:HP_0004970 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0002400 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001496 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031644 obo:IAO_0000115 "A concentric abnormal localized widening (dilatation) of the abdominal aorta that involves the full circumference of the vessel wall" ; dc:date "2017-12-17T14:14:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fusiform abdominal aortic aneurysm" ; rdfs:subClassOf obo:HP_0005112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0002400 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001516 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031645 obo:IAO_0000115 "An eccentric abnormal localized widening (dilatation) of the abdominal aorta that involves only a portion of the circumference of the vessel wall." ; dc:date "2017-12-17T14:14:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Saccular abdominal aortic aneurysm" ; rdfs:subClassOf obo:HP_0005112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0001987 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001516 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031646 obo:IAO_0000115 "A concentric abnormal localized widening (dilatation) of the aortic arch that involves the full circumference of the vessel wall." ; dc:date "2017-12-17T14:19:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fusiform aortic arch aneurysm" ; rdfs:subClassOf obo:HP_0005113 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0002400 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001508 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031647 obo:IAO_0000115 "An eccentric abnormal localized widening (dilatation) of the aortic arch that involves only a portion of the circumference of the vessel wall." ; dc:date "2017-12-17T14:19:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Saccular aortic arch aneurysm" ; rdfs:subClassOf obo:HP_0005113 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0001987 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001508 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031648 obo:IAO_0000115 "A focal defect in the elastic lamina of the aortic wall that leads to localized medial disruption and potential rupture." ; dc:date "2017-12-17T14:55:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pentrating aortic ulcers are typically caused by atherosclerotic lesions." ; rdfs:label "Penetrating aortic ulcer" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0031649 obo:IAO_0000115 "Tearing of the aortic wall generally associated with profuse internal bleeding." ; dc:date "2017-12-17T15:01:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aortic rupture" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0031650 obo:IAO_0000115 "Any functional defect of the mitral or tricuspid valve." ; dc:date "2017-12-17T15:17:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal atrioventricular valve physiology" ; rdfs:subClassOf obo:HP_0031653 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002133 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031651 obo:IAO_0000115 "Any functional defect of the tricuspid valve." ; dc:date "2017-12-17T15:19:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal tricuspid valve physiology" ; rdfs:subClassOf obo:HP_0031650 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002134 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031652 dc:date "2017-12-17T15:20:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal aortic valve physiology" ; rdfs:subClassOf obo:HP_0031653 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031653 obo:IAO_0000115 "Any functional abnormality of a cardiac valve." ; dc:date "2017-12-17T15:21:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal heart valve physiology" ; rdfs:subClassOf obo:HP_0011025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000946 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031654 obo:IAO_0000115 "Any functional anomaly of the pumonary valve." ; dc:date "2017-12-17T15:24:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary valve physiology" ; rdfs:subClassOf obo:HP_0031653 . obo:HP_0031655 obo:IAO_0000115 "The presence of an aortic valve with four instead of the normal three cusps (flaps)." ; dc:date "2017-12-17T15:32:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Quadricuspid aortic valve" ; rdfs:subClassOf obo:HP_0031567 . obo:HP_0031656 obo:IAO_0000115 "Systolic anterior motion of the mitral valve (SAM) is a paradoxical motion of the anterior, and occasionally posterior, mitral valve leaflet towards the left ventricular outflow tract (LVOT) during systole." ; dc:date "2017-12-17T15:49:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Systolic anterior motion of the mitral valve" ; rdfs:subClassOf obo:HP_0031481 . obo:HP_0031657 obo:IAO_0000115 "Any abnormal noise generated by the beating heart." ; dc:date "2017-12-17T15:56:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The first two heart sounds, S1 and S2, define ventricular systole. S1 comprises the closure of the mitral and tricuspid valves. S2 is produced by aortic and pulmonic valve closure." ; rdfs:label "Abnormal heart sound" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0031658 obo:IAO_0000115 "The third heart sound (S3) is related to rapid filling in diastole. S3 can be a normal finding in children and adolescents but suggests heart failure in older patients." ; dc:date "2017-12-17T16:01:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "S3", "Ventricular gallop" ; a owl:Class ; rdfs:label "Third heart sound" ; rdfs:subClassOf obo:HP_0033113 . obo:HP_0031659 obo:IAO_0000115 "The fourth heart sound (S4) is a low-pitched sound that occurs just before the first heart sound (S1) when the atria contract to force blood into the left ventricle, that is, coincident with late diastolic filling of the ventricle due to atrial contraction." ; dc:date "2017-12-17T16:03:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atrial gallop", "Presystolic gallop", "S4" ; a owl:Class ; rdfs:comment "S4 occurs in late diastole, is associated with atrial contraction, and coincides with the P wave on the EKG." ; rdfs:label "Fourth heart sound" ; rdfs:subClassOf obo:HP_0033113 . obo:HP_0031660 obo:IAO_0000115 "Abnormally increased volume of the first heart sound." ; dc:date "2017-12-17T16:05:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "S1 may be loud in early phases of rheumatic mitral stenosis." ; rdfs:label "Loud first heart sound" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0031661 obo:IAO_0000115 "Any anomaly of the second heart sound (S2), which is produced by aortic (A2) and pulmonic (P2) valve closure. The A2-P2 interval normally increases with inspiration and narrows with expiration." ; dc:date "2017-12-17T16:06:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal second heart sound" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0031662 obo:IAO_0000115 "Lack of variation in the splitting between the two components of the second heart sound with respiration. Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration." ; dc:date "2017-12-17T16:08:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fixed splitting of S2" ; a owl:Class ; rdfs:comment "Fixed splitting of S2 may occur in patients with secundum atrial septal defect." ; rdfs:label "Fixed splitting of the second heart sound" ; rdfs:subClassOf obo:HP_0031661 . obo:HP_0031663 obo:IAO_0000115 "Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration. With paradoxical splitting, there is a delay in the closure of the aortic valve, so that A2 can follow P2; the individual components can be appreciated at the end of expiration and the interval narrows with inspiration (which is the oposite of the normal pattern)." ; dc:date "2017-12-17T16:11:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Paradoxical splitting of S2", "Reversed splitting of S2", "Reversed splitting of the second heart sound" ; a owl:Class ; rdfs:label "Paradoxical splitting of the second heart sound" ; rdfs:subClassOf obo:HP_0031661 . obo:HP_0031664 obo:IAO_0000115 "A heart murmur limited to systole, i.e., between the first and second heart sounds S1 and S2." ; dc:date "2017-12-17T16:16:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Systolic heart murmur" ; rdfs:subClassOf obo:HP_0030148 . obo:HP_0031665 obo:IAO_0000115 "A systolic murmur that begins after S1 and ends before S2, typically with a crescendo-decrescendo pattern." ; dc:date "2017-12-17T16:17:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A common cause of midsystolic murmurs in adults is aortic stenosis." ; rdfs:label "Midsystolic murmur" ; rdfs:subClassOf obo:HP_0031664 . obo:HP_0031666 obo:IAO_0000115 "A murmur that occurs in the latter phase of systole." ; dc:date "2017-12-17T16:19:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A late systolic murmur heard best at the apex of the heart may indicate mitral valve prolapse." ; rdfs:label "Late systolic murmur" ; rdfs:subClassOf obo:HP_0031664 . obo:HP_0031667 obo:IAO_0000115 "A heart murmur that occurs during the entire systolic phase from S1 to S2." ; dc:date "2017-12-17T16:20:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Holosystolic murmur" ; rdfs:subClassOf obo:HP_0031664 . obo:HP_0031668 obo:IAO_0000115 "A heart murmur that occurs during diastole, i.e., in the time between S2 and the subsequent S1." ; dc:date "2017-12-17T16:21:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Diastolic murmurs always signify structural heart disease." ; rdfs:label "Diastolic heart murmur" ; rdfs:subClassOf obo:HP_0030148 . obo:HP_0031669 obo:IAO_0000115 "A murmur that occurs in the middle of the diastolic phase." ; dc:date "2017-12-17T16:22:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A middiastolic murmur may indicate mitral stenosis." ; rdfs:label "Middiastolic murmur" ; rdfs:subClassOf obo:HP_0031668 . obo:HP_0031670 obo:IAO_0000115 "A murmur that occurs in both systole and diastole." ; dc:date "2017-12-17T16:23:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Continuous murmurs are related to pressure gradients that persist across systole and diastole. A classic example is the murmur related to patent ductus arteriosus." ; rdfs:label "Continuous heart murmur" ; rdfs:subClassOf obo:HP_0030148 . obo:HP_0031671 obo:IAO_0000115 "Typical atrial flutter is an organised atrial tachycardia. It can also be defined as a macroreentrant tachycardia confined to the right atrium. This arrhythmia has a 200-260 ms cycle length, although it may fluctuate depending on patient's previous treatment or ablation, congenital heart disease, etc. Ventricular rate response will be limited by the atrioventricular node conductions, usually presenting a 2:1 or 3:1 response, during atrial flutter. Typical (counter clockwise) flutter is associated with the common flutter pattern: a regular continuous undulation with dominant negative deflections in inferior leads II, III and aVF, often described also as a saw tooth pattern, and flat atrial deflections in leads I and aVL. Atrial deflections in V1 can be positive, biphasic or negative." ; dc:date "2017-12-17T16:44:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Typical atrial flutter" ; rdfs:subClassOf obo:HP_0004749 . obo:HP_0031672 obo:IAO_0000115 "A type of atrial flutter associated with rounded or bimodal positive deflections in inferior leads II, III and aVF, and a very characteristic bimodal negative wave in the shape of a W is seen in lead V1." ; dc:date "2017-12-17T16:47:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reverse typical atrial flutter" ; rdfs:subClassOf obo:HP_0004749 . obo:HP_0031673 obo:IAO_0000115 "A type of atrioventricular reentrant tachycardia (AVRT) where the atrioventricular node is used for anterograde conduction and the accessory pathway for retrograde conduction." ; dc:date "2017-12-17T16:55:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Orthodromic AVRT" ; a owl:Class ; rdfs:label "Orthodromic atrioventricular reentrant tachycardia" ; rdfs:subClassOf obo:HP_0011717 . obo:HP_0031674 obo:IAO_0000115 "A type of atrioventricular reentrant tachycardia (AVRT) where the accessory pathway is used for anterograde conduction and the atrioventricular node for retrograde conduction." ; dc:date "2017-12-17T16:57:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Antidromic AVRT" ; a owl:Class ; rdfs:label "Antidromic atrioventricular reentrant tachycardia" ; rdfs:subClassOf obo:HP_0011717 . obo:HP_0031675 obo:IAO_0000115 "A ventricular tachycardia (VT) characterized by right bundle branch block (RBBB) and left axis deviation (LAD) on electrocardiogram (ECG)." ; dc:date "2017-12-17T17:01:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fascicular left ventricular tachycardia occurs predominantly in young males (15-40 years old) without structural heart disease (idiopathic)." ; rdfs:label "Fascicular left ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0031676 obo:IAO_0000115 "A type of ventricular tachycardia that is characterized by uniform QRS complexes within each lead (i.e., each QRS is identical or nearly so)." ; dc:date "2017-12-17T17:06:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Monomorphic VT originates from a single ventricular focus." ; rdfs:label "Monomorphic ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0031677 obo:IAO_0000115 "A type of ventricular tachycardia that is characterized by variable QRS complexes within each lead (i.e., QRS complexes may be different from beat to beat)." ; dc:date "2017-12-17T17:08:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polymorphic ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0031678 obo:IAO_0000115 "A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from teh development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus." ; dc:date "2017-12-17T17:19:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0002621 . obo:HP_0031679 obo:IAO_0000115 "Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells)." ; dc:date "2017-12-17T17:29:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Type I lesions consist of the first microscopically and chemically detectable lipid deposits in the intima and the cell reactions associated with such deposits.The initial histological changes in the human intima are minimal. Small, isolated groups of macrophages containing lipid droplets (macrophage foam cells) form. In coronary arteries these cells pref- erentially accumulate in regions of the intima that have an adaptive intimal thickening of the eccentric type." ; rdfs:label "Type I atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0031680 obo:IAO_0000115 "Type II atherosclerotic lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid." ; dc:date "2017-12-17T17:31:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Type II atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0031681 obo:IAO_0000115 "Type III (intermediate) atherosclerotic lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions." ; dc:date "2017-12-17T17:33:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Type III atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0031682 obo:IAO_0000115 "Type V lesions are defined as lesions in which prominent new fibrous connective tissue has formed. When the new tissue is part of a lesion with a lipid core (type IV), this type of morphology may be referred to as fibroatheroma or type Va lesion. A type V lesion in which the lipid core and other parts of the lesion are calcified may be referred to as type Vb. A type V lesion in which a lipid core is absent and lipid in general is minimal may be referred to as type Vc. With these lesions, arteries are variously narrowed, generally more than with type IV. Importantly, as with type IV lesions, type V lesions may develop fissures, hematoma, and/or thrombus (type VI lesion), and for this reason too they are clinically relevant." ; dc:date "2017-12-17T17:38:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Type V atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0031683 obo:IAO_0000115 "Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes." ; dc:date "2017-12-17T17:45:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Morbidity and mortality from atherosclerosis is largely due to type IV and type V lesions in which disruptions of the lesion surface, hematoma or hemorrhage, and thrombotic deposits have developed. Type IV or V lesions with one or more of these additional features are classified as type VI and may also be referred to as complicated lesions. Type VI may be subdivided by the superimposed features. Thus, disruption of the surface may be labeled type VIa; hematoma or hemorrhage, type VIb; and thrombosis, type VIc. Type VIabc indicates the presence of all three features." ; rdfs:label "Type VI atherosclerotic lesion" ; rdfs:subClassOf obo:HP_0031678 . obo:HP_0031684 obo:IAO_0000115 "An atherosclerotic lesion located in the renal artery." ; dc:date "2017-12-17T18:25:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal artery atherosclerosis" ; rdfs:subClassOf obo:HP_0008776 . obo:HP_0031685 obo:IAO_0000115 "Abnormal level of metabolite or other abnormal analyte result in a stool test." ; dc:date "2017-12-17T21:04:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032483" ; oboInOwl:hasExactSynonym "Abnormal faeces composition", "Abnormal feces composition" ; oboInOwl:hasRelatedSynonym "Abnormal faecal test result", "Abnormal fecal test result" ; a owl:Class ; rdfs:label "Abnormal stool composition" ; rdfs:subClassOf obo:HP_0001939, obo:HP_0025033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000025 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001988 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031686 obo:IAO_0000115 "An abnormally elevated amount of alpha1-antitrypsin in the feces." ; dc:date "2017-12-17T21:09:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Alpha-1-antitrypsin is resistant to degradation by digestive enzymes and can therefore be used as a marker for the presence of blood proteins in the intestinal tract (e.g., protein-losing enteropathy)." ; rdfs:label "Increased stool alpha1-antitrypsin concentration" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0031687 dc:date "2017-12-17T21:17:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Accentuation of the pulmonic component of the second heart sound" ; a owl:Class ; rdfs:comment "The pulmonic component is considered to be abnormally loud in a subject over age 20 if it is greater than the aortic component in the second left ICS or if it is audible at the cardiac apex. This may be due either to pulmonary artery hypertension or right ventricular dilatation, with part of the right ventricle assuming the position normally occupied by the left ventricle. A split second sound at the apex is, therefore, definitely abnormal. The loud P2 commonly heard at the apex in patients with atrial septal defect is probably due to a dilated right ventricle encroaching upon the cardiac apex [source-NCBI:NBK341]." ; rdfs:label "Abnormally loud pulmonic component of the second heart sound" ; rdfs:subClassOf obo:HP_0031661 . obo:HP_0031688 obo:IAO_0000115 "Dysplasia in the erythroid lineage, which presents with a variety of morphological changes in the bone marrow, including nuclear budding or irregular nuclear contour in erythroblasts." ; dc:date "2017-12-17T22:04:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Erythroid dysplasia" ; rdfs:subClassOf obo:HP_0012130 . obo:HP_0031689 obo:IAO_0000115 "The presence of micro-megakaryocytes, hypo-lobed, or non-lobed nuclei in megakaryocytes of all sizes and multiple, widely-separated nuclei." ; dc:date "2017-12-17T22:09:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dysmegakaryopoiesis" ; a owl:Class ; rdfs:label "Megakaryocyte dysplasia" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0031690 obo:IAO_0000115 "An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system." ; dc:date "2017-12-17T22:11:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Opportunistic infection are infections that occur more often or are more severe in people with weakened immune systems than in those with normal immune system functioning." ; rdfs:label "Opportunistic infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0031691 obo:IAO_0000115 "An unusually severe viral infection." ; dc:date "2017-12-17T22:28:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The majority of viral infections acquired by nonimmunosuppressed individuals are asymptomatic or result in mild clinical manifestations. These individuals are able to mount effective immune responses that either clear the virus from the body or, for viruses that establish latency, maintain the virus in a dormant state. For individuals who are immunocompromised, because of a genetic immunodeficiency or immunosuppressive drug therapy, viral infections may result in life-threatening disease. Such patients present with infections that are severe, persistent, recurrent, or refractory to therapy and are usually caused by viruses of low virulence prevalent in the community." ; rdfs:label "Severe viral infection" ; rdfs:subClassOf obo:HP_0032169 . obo:HP_0031692 obo:IAO_0000115 "An unusually severe infection by cytomegalovirus." ; dc:date "2017-12-17T22:31:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A typical mononucleosis syndrome consists of an acute febrile illness with an increase of 50 percent or more in the number of lymphocytes or monocytes, with at least 10 percent of the lymphocytes being atypical. Immunocompromised patients may experience more severe complications such as CMV retinitis." ; rdfs:label "Severe cytomegalovirus infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0031693 obo:IAO_0000115 "An unusually severe Epstein Barr virus (EBV) infection." ; dc:date "2017-12-17T22:35:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fulminant infectious mononucleosis", "Severe EBV infection" ; a owl:Class ; rdfs:label "Severe Epstein Barr virus infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0031694 obo:IAO_0000115 "An unusually severe adenovirus infection." ; dc:date "2017-12-17T22:36:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Adenoviruses can cause an array of clinical diseases, including conjunctivitis, gastroenteritis, hepatitis, myocarditis, and pneumonia. Most of these occur in children younger than the age of 5 years and are generally self-limiting illnesses." ; rdfs:label "Severe adenovirus infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0031695 obo:IAO_0000115 "An unusually severe infection by a parainfluenza virus." ; dc:date "2017-12-17T22:38:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe parainfluenza infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0031696 obo:IAO_0000115 "A viral infection that fails to be contained by the immune sytem and spreads throughout the body." ; dc:date "2017-12-17T22:39:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated viral infection" ; rdfs:subClassOf obo:HP_0033432 . obo:HP_0031697 obo:IAO_0000115 "A dissemination viral infection caused by a live attenuated vaccine virus." ; dc:date "2017-12-17T22:41:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated infection with live vaccine virus" ; rdfs:subClassOf obo:HP_0031696 . obo:HP_0031698 obo:IAO_0000115 "Failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis." ; obo:IAO_0100001 "HP:0020087" ; dc:date "2017-12-17T22:43:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Disseminated Bacillus Calmette-Guerin infection" ; owl:deprecated true . obo:HP_0031699 obo:IAO_0000115 "Failure to contain infection by a protozoan of the genus Cryptosporidium, leading to spread to many parts of the body." ; dc:date "2017-12-17T22:46:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated cryptosporidium infection" ; rdfs:subClassOf obo:HP_0020104, obo:HP_0031690 . obo:HP_0031700 obo:IAO_0000115 "A parasitic infection whereby the parasite invades (migrates through) tissues of the infected host." ; dc:date "2017-12-17T22:50:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Invasive parasitic infection" ; rdfs:subClassOf obo:HP_0020108, obo:HP_0031690 . obo:HP_0031701 obo:IAO_0000115 "The presence of inflammatory cells in the aqueous humor of the anterior chamber of the eye." ; dc:date "2017-12-18T00:14:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The terms for anterior chamber cells can be used to select the grade (total number of cells) and then Anterior chamber red blood cells or inflammatory cells can be chosen to specificy whether one or both cells are present. In some scenarios, both cell types may be observed, e.g., followiong trauma." ; rdfs:label "Anterior chamber inflammatory cells" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0031702 obo:IAO_0000115 "The presence of erythrocyte in the aqueous humor of the anterior chamber of the eye." ; dc:date "2017-12-18T00:15:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anterior chamber RBCs" ; a owl:Class ; rdfs:comment "The terms for anterior chamber cells can be used to select the grade (total number of cells) and then Anterior chamber red blood cells or inflammatory cells can be chosen to specificy whether one or both cells are present. In some scenarios, both cell types may be observed, e.g., followiong trauma." ; rdfs:label "Anterior chamber red blood cells" ; rdfs:subClassOf obo:HP_0000593 . obo:HP_0031703 obo:IAO_0000115 "Any structural anomaly of the ear." ; dc:date "2017-12-18T00:20:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:4867" ; a owl:Class ; rdfs:label "Abnormal ear morphology" ; rdfs:subClassOf obo:HP_0000598 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031704 obo:IAO_0000115 "Any functional anomaly of the ear." ; dc:date "2017-12-18T00:20:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ear physiology" ; rdfs:subClassOf obo:HP_0000598 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031705 obo:IAO_0000115 "A compensatory head posture occurs when the head is deviated out of the normal primary straight head position in order to compensate for an ocular problem." ; dc:date "2017-12-18T00:24:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An abnormal position of the head can be due to an ocular or a non-ocular problem. We reserve this term for abnormal head positions that are compensatory for an ocular problem." ; rdfs:label "Compensatory head posture" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0031706 obo:IAO_0000115 "A tendency to hold the chin depressed (lowered) to compensate for a limitation of eye movement." ; dc:date "2017-12-18T00:26:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Compensatory chin depression" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0031707 obo:IAO_0000115 "A tendency to turn the face to the right to compensate for a limitation of eye movement." ; dc:date "2017-12-18T00:27:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "With a sixth cranial nerve palsy there is a weakened lateral rectus muscule and the affected patient will often turn the head towards the affected eye." ; rdfs:label "Compensatory face turn to the right" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0031708 obo:IAO_0000115 "A tendency to turn the face to the left to compensate for a limitation of eye movement." ; dc:date "2017-12-18T00:30:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "With a sixth cranial nerve palsy there is a weakened lateral rectus muscule and the affected patient will often turn the head towards the affected eye." ; rdfs:label "Compensatory face turn to the left" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0031709 obo:IAO_0000115 "A tendency to tilt the head towards the right shoulder to compensate for a limitation of eye movement." ; dc:date "2017-12-18T00:31:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "With fourth cranial nerve palsy leading to weakness of the superior oblique muscle, affected persons tilt the head away from the affected eye as both eyes are most straight in this position." ; rdfs:label "Compensatory head tilt to the right shoulder" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0031710 obo:IAO_0000115 "A tendency to tilt the head towards the left shoulder to compensate for a limitation of eye movement." ; dc:date "2017-12-18T00:33:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "With fourth cranial nerve palsy leading to weakness of the superior oblique muscle, affected persons tilt the head away from the affected eye as both eyes are most straight in this position." ; rdfs:label "Compensatory head tilt to the left shoulder" ; rdfs:subClassOf obo:HP_0031705 . obo:HP_0031711 obo:IAO_0000115 "An abdominal aortic aneurysm that is not symmetric around its axis (not axisymmetric)." ; dc:date "2017-12-22T11:19:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Abdominal aortic aneurysms (AAAs) in an advanced stage of development are truly asymmetric, due to the presence of tissue surrounding the abdominal aorta and to the vertebral column located posterior to this artery segment. This makes a large AAA less fusiform and to grow apart from the centerline of the lumen, accounting for a major anterior dilation and a more flat posterior surface." ; rdfs:label "Asymmetric abdominal aortic aneurysm" ; rdfs:subClassOf obo:HP_0005112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_90 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001516 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031713 obo:IAO_0000115 "A form of divergent strabismus (exotropia) in which the eye turns outward at all distances and at all times." ; dc:date "2018-01-13T13:23:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Constant exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031714 obo:IAO_0000115 "A type of divergent strabismus (exotropia) in which an eye tends to turn outwards (i.e., the eye squints) mainly when looking at distant objects. The eyes tend to remain straight when they look at near objects. Distance exotropia may be constant or intermittent." ; dc:date "2018-01-13T13:25:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Distance exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031715 obo:IAO_0000115 "An intermittent exotropia where there is binocular single vision on distance fixation and exotropia at near (intermittent or constant)." ; dc:date "2018-01-13T13:30:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Near exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031716 obo:IAO_0000115 "A type of exotropia (divergent strabismus) in which binocular single vision alternates with large angle exotropia in rhythmic cycle." ; dc:date "2018-01-13T13:31:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cyclic exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031717 obo:IAO_0000115 "A type of exotropia in which either eye may be used for fixation." ; dc:date "2018-01-13T13:33:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Alternating strabismus" ; a owl:Class ; rdfs:label "Alternating exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031718 obo:IAO_0000115 "Exotropia in an individual who has previously had esotropia or esophoria." ; dc:date "2018-01-13T13:36:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Consecutive exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031719 obo:IAO_0000115 "Exotropia (intermittent or constant) on distance fixation with binocular single vision on near fixation under all testing conditions. The accommodative convergence/accommodation (AC:A) ratio is within normal limits." ; dc:date "2018-01-13T13:40:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "True distance exotropia" ; rdfs:subClassOf obo:HP_0031714 . obo:HP_0031720 obo:IAO_0000115 "Exotropia (intermittent or constant) worse for distance fixation in which the near angle of deviation increases (or near exophoria becomes exotropia) with: (1) prolonged disruption of fusion and/or (2) elimination of accommodation." ; dc:date "2018-01-13T13:40:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Simulated distance exotropia" ; rdfs:subClassOf obo:HP_0031714 . obo:HP_0031721 obo:IAO_0000115 "A type of divergent strabismus (exotropia) that develops in a poorly seeing eye." ; dc:date "2018-01-13T14:03:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Secondary exotropia" ; a owl:Class ; rdfs:label "Sensory exotropia" ; rdfs:subClassOf obo:HP_0000577 . obo:HP_0031722 obo:IAO_0000115 "An intermittent esotropia where there is binocular single vision on distance fixation and esotropia at near even when the accommodation is relieved." ; dc:date "2018-01-13T14:06:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Non-accomodative convergence excess esotropia" ; a owl:Class ; rdfs:label "Near esotropia" ; rdfs:subClassOf obo:HP_0031760 . obo:HP_0031723 obo:IAO_0000115 "Convergent squint which follows loss or impairment of vision." ; dc:date "2018-01-13T14:08:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sensory esotropia" ; a owl:Class ; rdfs:label "Secondary esotropia" ; rdfs:subClassOf obo:HP_0000565 . obo:HP_0031724 obo:IAO_0000115 "A small angle heterotropia (usually of 10 diopters or less) in which a form of binocular single vision occurs." ; dc:date "2018-01-13T14:16:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Microtropia" ; rdfs:subClassOf obo:HP_0032012 . obo:HP_0031725 obo:IAO_0000115 "A form of latent strabismus (heterophoria) in which, on dissociation, the occluded eye deviates downwards." ; dc:date "2018-01-13T14:23:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypophoria" ; rdfs:subClassOf obo:HP_0025588, obo:HP_0032011 . obo:HP_0031726 obo:IAO_0000115 "A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated inward (medially) to each other." ; dc:date "2018-01-14T15:35:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Incyclotropia" ; rdfs:subClassOf obo:HP_0031776 . obo:HP_0031727 obo:IAO_0000115 "A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated outward (laterally) to each other." ; dc:date "2018-01-14T15:39:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Excyclotropia" ; rdfs:subClassOf obo:HP_0031776 . obo:HP_0031728 obo:IAO_0000115 "A form of hypermetropia with not more than +2.00 diopters." ; dc:date "2018-01-21T13:18:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mild hyperopia" ; a owl:Class ; rdfs:label "Mild hypermetropia" ; rdfs:subClassOf obo:HP_0000540 . obo:HP_0031729 obo:IAO_0000115 "A form of hypermetropia with more than +2.00 diopters but not more than +5.00 diopters." ; dc:date "2018-01-21T13:20:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Moderate hyperopia" ; a owl:Class ; rdfs:label "Moderate hypermetropia" ; rdfs:subClassOf obo:HP_0000540 . obo:HP_0031730 obo:IAO_0000115 "A form of myopia related to an axial length above the norm and too long for the refractive power of the whole optical system of the eye." ; dc:date "2018-01-21T13:22:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Axial myopia" ; rdfs:subClassOf obo:HP_0000545 . obo:HP_0031731 obo:IAO_0000115 "Increased lacrimation owing to overproduction of tears." ; dc:date "2018-01-21T13:27:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased tear production" ; rdfs:subClassOf obo:HP_0009926 . obo:HP_0031732 obo:IAO_0000115 "A form of watery eye associated with overproduction of tears due to an increased parasympathetic drive to the secretory component of the lacrimal system (lacrimal gland); this could be due to pro-secretory drug use (e.g. pilocarpine) or autonomic disturbance." ; dc:date "2018-01-21T13:29:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased basal tear production" ; rdfs:subClassOf obo:HP_0031731 . obo:HP_0031733 obo:IAO_0000115 "A form of watery eye associated with overproduction of tears due to reflex tearing in response to a local irritant (e.g. trichiasis or foreign body), chronic ocular surface disease (e.g. blepharitis) or systemic disease (e.g. thyroid eye disease)." ; dc:date "2018-01-21T13:32:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reflex tearing" ; rdfs:subClassOf obo:HP_0031731 . obo:HP_0031734 obo:IAO_0000115 "A form of watery eye associated with abnormal lid tone and/or lid position. The former is due to lid laxity (common involutional change in the elderly) or a weak orbicularis muscle (e.g. due to VII cranial nerve palsy). The latter is typically associated with ectropion causing punctal eversion." ; dc:date "2018-01-21T13:36:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lacrimal pump failure" ; rdfs:subClassOf obo:HP_0009926 . obo:HP_0031736 obo:IAO_0000115 "An abnormal inversion of the eyelid towards the globe resulting from inferior retractor muscle dysfunction with tissue laxity and, possibly, overriding of the preseptal orbicularis muscle over the pretarsal orbicularis muscle." ; dc:date "2018-01-21T13:40:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Involutional entropion" ; rdfs:subClassOf obo:HP_0000621 . obo:HP_0031737 obo:IAO_0000115 "Abnormal inversion (turning inward) of the eyelid towards the globe associated with scarring that vertically shortens the posterior lamella of the eyelid." ; dc:date "2018-01-21T13:41:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cicatricial entropion" ; rdfs:subClassOf obo:HP_0000621 . obo:HP_0031738 obo:IAO_0000115 "A type of entropion (abnormal inversion of the eyelid towards the globe) that is related to a mass effect of a lesion (e.g., a tumor) that pulls the eyelid margin away from the globe." ; dc:date "2018-01-21T13:42:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mechanical entropion" ; rdfs:subClassOf obo:HP_0000621 . obo:HP_0031739 obo:IAO_0000115 "A functional anomaly of the inferior or superior oblique muscle." ; dc:date "2018-01-21T13:53:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The superior oblique muscle is responsible for incyclotorsion (inward turning) or the eye. The inferior oblique muscle is responsible for excyclotorsion (outward turning) or the eye." ; rdfs:label "Abnormal oblique muscle physiology" ; rdfs:subClassOf obo:HP_0025590 . obo:HP_0031740 obo:IAO_0000115 "A functional anomaly of the medial rectus muscle or lateral rectus muscle." ; dc:date "2018-01-21T13:56:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal horizontal rectus muscle physiology" ; rdfs:subClassOf obo:HP_0031755 . obo:HP_0031741 obo:IAO_0000115 "Reduced ocular movement by the inferior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-21T14:05:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior oblique muscle underaction" ; rdfs:subClassOf obo:HP_0025598 . obo:HP_0031742 obo:IAO_0000115 "Reduced movement by the inferior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-21T14:07:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior rectus muscle underaction" ; rdfs:subClassOf obo:HP_0025601 . obo:HP_0031743 obo:IAO_0000115 "Excessive action of the inferior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." ; dc:date "2018-01-21T14:09:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior rectus muscle overaction" ; rdfs:subClassOf obo:HP_0025600 . obo:HP_0031744 obo:IAO_0000115 "Decreased strength of the superior rectus muscle." ; dc:date "2018-01-21T14:10:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior rectus muscle weakness" ; rdfs:subClassOf obo:HP_0025603 . obo:HP_0031745 obo:IAO_0000115 "Excessive action of the superior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." ; dc:date "2018-01-21T14:11:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior rectus muscle overaction" ; rdfs:subClassOf obo:HP_0025603 . obo:HP_0031746 obo:IAO_0000115 "Mechanical limitation of the range of movement of the superior rectus muscle." ; dc:date "2018-01-21T14:13:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to deficits produced by primary muscle weakness, restriction means that the affected extraocular muscle cannot move passively any more than actively." ; rdfs:label "Superior rectus muscle restriction" ; rdfs:subClassOf obo:HP_0031744 . obo:HP_0031747 obo:IAO_0000115 "Reduced movement of the superior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-21T14:16:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior rectus muscle underaction" ; rdfs:subClassOf obo:HP_0031744 . obo:HP_0031748 obo:IAO_0000115 "A functional anomaly of the superior or inferior rectus muscle." ; dc:date "2018-01-21T14:18:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vertical rectus muscle physiology" ; rdfs:subClassOf obo:HP_0031755 . obo:HP_0031749 obo:IAO_0000115 "A functional anomaly of the lateral rectus muscle." ; dc:date "2018-01-21T14:19:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The lateral rectus muscle is responsible for abduction of the globe (moving the eyeball away from the nose)." ; rdfs:label "Abnormal lateral rectus muscle physiology" ; rdfs:subClassOf obo:HP_0031740 . obo:HP_0031750 obo:IAO_0000115 "Decreased strength (ability to move) of the lateral rectus muscle." ; dc:date "2018-01-21T14:21:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral rectus muscle weakness" ; rdfs:subClassOf obo:HP_0031749 . obo:HP_0031751 obo:IAO_0000115 "Reduced movement of the lateral rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-21T14:23:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral rectus muscle underaction" ; rdfs:subClassOf obo:HP_0031750 . obo:HP_0031752 obo:IAO_0000115 "Excessive action of the lateral rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." ; dc:date "2018-01-21T14:24:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral rectus muscle overaction" ; rdfs:subClassOf obo:HP_0031749 . obo:HP_0031753 obo:IAO_0000115 "Decreased strength of the medial rectus muscle." ; dc:date "2018-01-21T14:25:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial rectus muscle weakness" ; rdfs:subClassOf obo:HP_0025606 . obo:HP_0031754 obo:IAO_0000115 "Excessive action of the medial rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." ; dc:date "2018-01-21T14:26:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial rectus muscle overaction" ; rdfs:subClassOf obo:HP_0025606 . obo:HP_0031755 obo:IAO_0000115 "A functional anomaly of a vertical or horizontal rectus muscle." ; dc:date "2018-01-21T14:27:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal rectus muscle physiology" ; rdfs:subClassOf obo:HP_0025590 . obo:HP_0031756 obo:IAO_0000115 "Reduced movement of the medial rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." ; dc:date "2018-01-21T14:29:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial rectus muscle underaction" ; rdfs:subClassOf obo:HP_0031753 . obo:HP_0031757 obo:IAO_0000115 "Mechanical limitation of the range of movement of the medial rectus muscle." ; dc:date "2018-01-21T14:30:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to deficits produced by primary muscle weakness, restriction means that the affected extraocular muscle cannot move passively any more than actively." ; rdfs:label "Medial rectus muscle restriction" ; rdfs:subClassOf obo:HP_0031753 . obo:HP_0031758 obo:IAO_0000115 "Mechanical limitation of the range of movement of the lateral rectus muscle." ; dc:date "2018-01-21T14:33:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral rectus muscle restriction" ; rdfs:subClassOf obo:HP_0031750 . obo:HP_0031759 obo:IAO_0000115 "A form of convergent strabismus (esotropia) in which the deviation is present under all conditions (ie at all distances and at all times)." ; dc:date "2018-01-21T14:43:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basic (constant) esotropia" ; a owl:Class ; rdfs:label "Basic constant esotropia" ; rdfs:subClassOf obo:HP_0031760 . obo:HP_0031760 obo:IAO_0000115 "A form of esotropia in which the angle of deviation is not affected by accommodative effort." ; dc:date "2018-01-21T14:46:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Non-accomodative esotropia" ; rdfs:subClassOf obo:HP_0000565 . obo:HP_0031761 obo:IAO_0000115 "Constant esotropia occurring before 6 months of age. It is typically associated with a large angle of deviation, alternating fixation (therefore low risk of amblyopia) and poor potential for binocular single vision. Other features that might be present in individuals with infantile (constant) esotropia include latent nystagmus or manifest latent nystagmus, dissociated vertical divergence, cyclotropia, abnormal head posture, limited abduction." ; dc:date "2018-01-21T14:47:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Infantile (constant) esotropia" ; a owl:Class ; rdfs:label "Infantile constant esotropia" ; rdfs:subClassOf obo:HP_0031760 . obo:HP_0031762 obo:IAO_0000115 "An intermittent esotropia where binocular single vision is present on near fixation and an esotropia on distance fixation. Often associated with myopia and aging." ; dc:date "2018-01-21T14:47:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Divergence insufficiency" ; a owl:Class ; rdfs:label "Distance esotropia" ; rdfs:subClassOf obo:HP_0031760 . obo:HP_0031763 obo:IAO_0000115 "Convergent strabismus in which normal binocular single vision is alternating with large angle esotropia in rhythmic cycle." ; dc:date "2018-01-21T14:47:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cyclic esotropia" ; rdfs:subClassOf obo:HP_0031760 . obo:HP_0031764 obo:IAO_0000115 "Esotropia in which normal binocular single vision is present for all distances when the hypermetropic refractive error is corrected. Esotropia is present for near and distance on accommodation without correction." ; dc:date "2018-01-21T14:47:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fully accomodative esotropia" ; rdfs:subClassOf obo:HP_0020046 . obo:HP_0031765 obo:IAO_0000115 "A form of constant esotropia in which the angle of deviation is partially affected by accommodative effort. Typically there is esotropia at near and distance with hypermetropic correction and the angle of deviation increases without glasses." ; dc:date "2018-01-21T14:48:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Constant esotropia with an accommodative component", "Constant esotropia with an accommodative element" ; a owl:Class ; rdfs:label "Partially accomodative esotropia" ; rdfs:subClassOf obo:HP_0020046 . obo:HP_0031766 obo:IAO_0000115 "An intermittent esotropia with binocular single vision present at distance fixation but esotropia on accommodation for near fixation. Usually associated with hypermetropia but patients can be emmetropic and rarely myopic. Associated with a high accommodative convergence/accommodation (AC/A) ratio." ; dc:date "2018-01-21T14:48:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Convergence excess esotropia" ; rdfs:subClassOf obo:HP_0020046 . obo:HP_0031767 obo:IAO_0000115 "Esotropia in a patient who has previously had exotropia or exophoria; may be constant or intermittent and usually follows surgical overcorrection." ; dc:date "2018-01-21T14:48:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Consecutive esotropia" ; rdfs:subClassOf obo:HP_0000565 . obo:HP_0031768 obo:IAO_0000115 "Fixation of an object in the area adjacent to the fovea." ; dc:date "2018-01-21T14:54:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Parafoveal fixation" ; rdfs:subClassOf obo:HP_0025549 . obo:HP_0031769 obo:IAO_0000115 "Fixation of an object in a peripheral area of the retina." ; dc:date "2018-01-21T14:55:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peripheral fixation" ; rdfs:subClassOf obo:HP_0025549 . obo:HP_0031770 obo:IAO_0000115 "A type of epicanthus in which a medial vertical fold is present between upper and lower lids." ; dc:date "2018-01-25T11:23:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Epicanthus palpebralis" ; rdfs:subClassOf obo:HP_0000286 . obo:HP_0031771 obo:IAO_0000115 "A type of epicanthus in which a primarily upper lid fold is present." ; dc:date "2018-01-25T11:24:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Epicanthus tarsalis is a normal anatomic variant in the Asian population." ; rdfs:label "Epicanthus tarsalis" ; rdfs:subClassOf obo:HP_0000286 . obo:HP_0031772 obo:IAO_0000115 "Any structural anomaly of the posterior circulating artery (PCOM)." ; dc:date "2018-01-27T11:25:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The posterior circulating artery (PCOM) forms the posterior portion of the circle of Willis, connecting the interior carotid artery (proximal to its bifurcation into the anterior cerebral artery and the middle cerebral artery) with the posterior cerebral artery." ; rdfs:label "Abnormal posterior circulating artery morphology" ; rdfs:subClassOf obo:HP_0012518 . obo:HP_0031773 obo:IAO_0000115 "A widening (ballooning) localized in the wall of the posterior communicating artery." ; dc:date "2018-01-27T11:27:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Posterior communicating artery aneurysm can leads to an acute palsy of the third cranial nerve with ipsilateral pupil dilation. Posterior communicating aneurysms can be classified into aneurysms that project laterally and below the tentorial incisura and cause oculomotor nerve compression, and aneurysms that project laterally above the tentorium that can manifest as temporal lobe hematoma if they rupture." ; rdfs:label "Posterior communicating artery aneurysm" ; rdfs:subClassOf obo:HP_0031772 . obo:HP_0031774 obo:IAO_0000115 "A funnel-shaped symmetrical enlargement of the origin of the posterior communicating artery at its junction with the internal carotid artery." ; dc:date "2018-01-27T11:28:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "PCOM infundibula are often considered as normal anatomical variants devoid of pathogenic significance, but have been noted to progress to aneurysms in some cases." ; rdfs:label "Posterior communicating artery infundibulum" ; rdfs:subClassOf obo:HP_0031772 . obo:HP_0031775 obo:IAO_0000115 "An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them." ; dc:date "2018-01-27T11:35:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Paralytic strabismus" ; a owl:Class ; rdfs:label "Neurogenic strabismus" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0031776 obo:IAO_0000115 "A form of manifest strabismus (heterotropia) in which the one eye is wheel rotated so that the upper end of its vertical axis is nasal (incyclotropia) or temporal (excyclotropia)." ; dc:date "2018-01-27T11:38:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cyclotropia" ; rdfs:subClassOf obo:HP_0025589, obo:HP_0032012 . obo:HP_0031777 obo:IAO_0000115 "A form of latent strabismus (heterophoria) in which the occluded eye wheel-rotates on dissociation." ; dc:date "2018-01-27T11:40:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cyclophoria" ; rdfs:subClassOf obo:HP_0025589, obo:HP_0032011 . obo:HP_0031778 obo:IAO_0000115 "A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated inward (medially) to each other." ; dc:date "2018-01-27T11:40:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Incyclophoria" ; rdfs:subClassOf obo:HP_0031777 . obo:HP_0031779 obo:IAO_0000115 "A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated outward (laterally) to each other." ; dc:date "2018-01-27T11:47:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Excyclophoria" ; rdfs:subClassOf obo:HP_0031777 . obo:HP_0031780 obo:IAO_0000115 "A type of ascites in which there are large numbers of eosinophils in the ascitis fluid." ; dc:date "2018-01-27T12:22:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Eosinophilic ascites" ; rdfs:subClassOf obo:HP_0001541, obo:HP_0032064 . obo:HP_0031781 obo:IAO_0000115 "A type of microtropia with no manifest movement on cover test, the eccentric fixation point coinciding with the angle of ARC." ; dc:date "2018-01-28T11:42:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Microtropia with identity" ; rdfs:subClassOf obo:HP_0031724 . obo:HP_0031782 obo:IAO_0000115 "A type of microtropia in which the manifest movement is demonstrated on the cover-uncover test." ; dc:date "2018-01-28T11:44:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Microtropia without identity" ; rdfs:subClassOf obo:HP_0031724 . obo:HP_0031783 obo:IAO_0000115 "A developmental defect in which the coronary sinus fails to form." ; dc:date "2018-01-28T12:02:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:2841" ; a owl:Class ; rdfs:label "Absent coronary sinus" ; rdfs:subClassOf obo:HP_0011642 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031784 obo:IAO_0000115 "Any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise." ; dc:date "2018-01-28T12:14:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:1431" ; a owl:Class ; rdfs:label "Abnormal ascending aorta morphology" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0031785 obo:IAO_0000115 "An abnormality in voluntary or involuntary eyelid movements or their control." ; dc:date "2018-01-28T12:51:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal eyelid movement" ; rdfs:subClassOf obo:HP_0031879 . obo:HP_0031786 obo:IAO_0000115 "Transient eyelid retraction during refixation from down to straight ahead." ; dc:date "2018-01-28T12:52:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cogan eyelid twitch", "Eyelid twitch", "Lid twitch" ; a owl:Class ; rdfs:label "Cogan lid twitch" ; rdfs:subClassOf obo:HP_0031785 . obo:HP_0031787 obo:IAO_0000115 "Astigmatism in which the refractive power of the vertical meridian is the greatest." ; dc:date "2018-01-28T13:31:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oblique astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031788 obo:IAO_0000115 "Refractive error in which the vertical meridian is relatively hypermetropic and the horizontal meridian is relatively myopic (or ocular astigmatism in which the refractive power of the horizontal meridian is the greatest)." ; dc:date "2018-01-28T13:33:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "With the rule astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031789 obo:IAO_0000115 "Astigmatism with more plus power on the horizontal meridian." ; dc:date "2018-01-28T13:36:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Against the rule astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031790 obo:IAO_0000115 "A type of astigmatism in which an unequal curvature of the cornea and some cases additionally of the lens causes one meridian of the eye to be hyperopic (farsighted) and a second meridian that is perpendicular to the first to be myopic (nearsighted)." ; dc:date "2018-01-28T13:37:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mixed astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031791 obo:IAO_0000115 "A type of astigmatism related to an irregular shape of the lens." ; dc:date "2018-01-28T13:40:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lenticular astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031792 obo:IAO_0000115 "A type of astigmatism in which the principle meridians are not 90 degrees apart and which is associated with loss of vision." ; dc:date "2018-01-28T13:51:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Irregular astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0031793 obo:IAO_0000115 "An increased concentration of leptin in the blood." ; dc:date "2018-02-25T14:05:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating leptin level" ; a owl:Class ; rdfs:label "Increased serum leptin" ; rdfs:subClassOf obo:HP_0004361 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009758 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031794 obo:IAO_0000115 "A decrease below the normal concentration of glycerol in the blood." ; dc:date "2018-02-25T14:13:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating glycerol level" ; rdfs:subClassOf obo:HP_0031795 . obo:HP_0031795 obo:IAO_0000115 "Any deviation from the normal concentration of glycerol in the blood." ; dc:date "2018-02-25T14:28:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating glycerol level" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0031796 obo:IAO_0000115 "Applies to a sign, symptom or manifestation that occurs multiple times separated by intervals in which the sign, symptom, or manifestation is not present." ; dc:date "2018-02-25T14:40:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intermittent" ; a owl:Class ; rdfs:label "Recurrent" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0031797 obo:IAO_0000115 "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual." ; dc:date "2018-02-25T14:55:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Natural history of disease" ; a owl:Class ; rdfs:label "Clinical course" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0031798 obo:IAO_0000115 "Increased circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100." ; dc:date "2018-02-25T15:02:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated ApoB level", "Elevated apolipoprotein B level" ; a owl:Class ; rdfs:label "Elevated circulating apolipoprotein B concentration" ; rdfs:subClassOf obo:HP_0033460 . obo:HP_0031799 obo:IAO_0000115 "Concentration of apolipoprotein A-I below the lower limit of normal. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in plasma. Defects in this gene are associated with HDL deficiencies, including Tangier disease." ; dc:date "2018-02-25T15:04:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased apo-AI level", "Decreased apoA-I level", "Decreased apolipoprotein AI level" ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein A-I concentration" ; rdfs:subClassOf obo:HP_0033459 . obo:HP_0031800 obo:IAO_0000115 "An increased concentration in blood of apolipoprotein A-II, a major component of HDL particles, associated with triglyceride and glucose metabolism." ; dc:date "2018-02-25T15:06:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated APOAII level", "Elevated Apo-AII level", "Elevated apoA-II level", "Elevated apolipoprotein A-II level" ; a owl:Class ; rdfs:label "Elevated circulating apolipoprotein A-II concentration" ; rdfs:subClassOf obo:HP_0033460 . obo:HP_0031801 obo:IAO_0000115 "Any functional anomaly of the vocal cord." ; dc:date "2018-03-04T12:07:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vocal cord dysfunction" ; rdfs:subClassOf obo:HP_0001608 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003706 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031803 obo:IAO_0000115 "Bleeding within the fundus of the eye." ; dc:date "2018-03-07T15:30:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fundus haemorrhage" ; a owl:Class ; rdfs:label "Fundus hemorrhage" ; rdfs:subClassOf obo:HP_0001098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003951 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031804 dc:date "2018-03-07T15:32:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Premacular haemorrhage" ; a owl:Class ; rdfs:label "Premacular hemorrhage" ; rdfs:subClassOf obo:HP_0025240 . obo:HP_0031805 obo:IAO_0000115 "A subtype of fundus hemorrhage occurring within the neurosensory retina. Intraretinal haemorrhages may be 'dot' or' blot' shaped or flame shaped depending upon their depth within the retina." ; dc:date "2018-03-07T15:35:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraretinal haemorrhage" ; a owl:Class ; rdfs:comment "Although the fundoscopic appearence of an intraretinal hemorrhage can exibit significant variability it can typically be distinguished from a subretinal hemorrhage (occuring between the neurosensory retina and the RPE) or a sub-ILM hemorrhage (occuring between the internal limiting membrane and the neurosensory retina)." ; rdfs:label "Intraretinal hemorrhage" ; rdfs:subClassOf obo:HP_0000573 . obo:HP_0031806 obo:IAO_0000115 "Any deviation from the normal number of basophils per volume in the blood circulation." ; dc:date "2018-04-04T01:11:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal basophil count" ; rdfs:subClassOf obo:HP_0001912, obo:HP_0032309 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031807 obo:IAO_0000115 "An abnormally increased count of basophils per volume in the blood circulation." ; dc:date "2018-04-04T01:15:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basophilia" ; a owl:Class ; rdfs:label "Increased basophil count" ; rdfs:subClassOf obo:HP_0031806 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031808 obo:IAO_0000115 "An abnormally reduced count of basophils per volume in the blood circulation." ; dc:date "2018-04-04T01:16:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased basophil count" ; rdfs:subClassOf obo:HP_0031806 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031809 obo:IAO_0000115 "Shortening of the fourth and fifth metacarpals when the fist is clenched." ; dc:date "2018-04-28T14:18:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Archibald's metacarpal sign", "Knuckle dimple" ; a owl:Class ; rdfs:comment "In 1959, Archibald, Finlay, and De Vito were the first to describe a sign that depended on the relative lengths of the lateral three metacarpals (the metacarpal finding). When a line is drawn tangentially to the circumference of the heads (distal ends) of the fourth and fifth metacarpals, the extension of this line normally passes distally to the head of the third metacarpal and does not intersect the third metacarpal (negative metacarpal finding). In some hands such a line is tangential also to the circumference of the head of the third metacarpal (borderline metacarpal finding). In others the line runs through the distal end of the third metacarpal (positive metacarpal finding)." ; rdfs:label "Archibald's sign" ; rdfs:subClassOf obo:HP_0005916 . obo:HP_0031810 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react to gangliosides." ; dc:date "2018-04-28T14:42:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-ganglioside antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0031811 obo:IAO_0000115 "Presence of conjugated bilirubin in the urine." ; dc:date "2018-04-28T14:54:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bilirubinuria may lead to a dark yellow to orange color of the urine. Conjugated bilirubin is excreted in the urine and thus conjugated hyperbilirubinemia may lead to bilirubinuria." ; rdfs:label "Bilirubinuria" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0031812 obo:IAO_0000115 "Presence of nitrites in the urine." ; dc:date "2018-04-28T15:03:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Nitrituria may be diagnosed on the basis of a positive test result on a urine dipstick test. Nitrites are not found in normal urine. Some gram-positive and gram-negative bacteria metabolize nitrates in urine to nitrites, and a positive urine dipstick test for nitrites most commonly suggests a bacterial urinary tract infection." ; rdfs:label "Nitrituria" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0031813 obo:IAO_0000115 "An excess of eosinophilic cells in colonic tissue, i.e., eosinophilic infiltration in the colon." ; dc:date "2018-04-28T21:07:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic colitis", "Eosinophilic infiltration in the colon" ; a owl:Class ; rdfs:label "Colonic eosinophilia" ; rdfs:subClassOf obo:HP_0002037, obo:HP_0032064 . obo:HP_0031814 obo:IAO_0000115 "Repetition of one's own words or phrases." ; dc:date "2018-04-28T22:45:49Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Palilalia" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_0031815 obo:IAO_0000115 "A functional anomaly of the mouth (which is also known as the oral cavity)." ; dc:date "2018-04-29T14:50:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The physiological functions of the mouth include salivary gland secretory function, mastication (chewing) and preparation of food for swallowing." ; rdfs:label "Abnormal oral physiology" ; rdfs:subClassOf obo:HP_0000153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031816 obo:IAO_0000115 "Any structural anomaly of the mouth, which is also known as the oral cavity." ; dc:date "2018-04-29T14:55:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal oral morphology" ; rdfs:subClassOf obo:HP_0000153 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031817 obo:IAO_0000115 "An abnormally decreased concentration of parathyroid hormone." ; dc:date "2018-05-01T01:55:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating PTH level", "Decreased serum PTH", "Decreased serum parathyroid hormone", "Decreased serum parathyroid hormone level" ; a owl:Class ; rdfs:label "Decreased circulating parathyroid hormone level" ; rdfs:subClassOf obo:HP_0100530 . obo:HP_0031818 obo:IAO_0000115 "A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement." ; dc:date "2018-05-01T02:06:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal waist to hip ratio" ; rdfs:subClassOf obo:HP_0004323 . obo:HP_0031819 obo:IAO_0000115 "Increased waist-to-hip ratio (WHR) is a measurement above the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement." ; dc:date "2018-05-01T02:08:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased WHR", "Increased waist-hip ratio", "Increased waist-to-hip ratio" ; a owl:Class ; rdfs:label "Increased waist to hip ratio" ; rdfs:subClassOf obo:HP_0031818 . obo:HP_0031820 obo:IAO_0000115 "Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement." ; dc:date "2018-05-01T02:11:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased WHR", "Decreased waist-hip ratio", "Decreased waist-to-hip ratio" ; a owl:Class ; rdfs:label "Decreased waist to hip ratio" ; rdfs:subClassOf obo:HP_0031818 . obo:HP_0031821 obo:IAO_0000115 "Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." ; dc:date "2018-05-01T02:20:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal 6-hydroxypurine phosphoribosyltransferase level", "Abnormal GMP pyrophosphorylase level", "Abnormal GPRT level" ; a owl:Class ; rdfs:label "Abnormal hypoxanthine-guanine phosphoribosyltransferase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0031822 obo:IAO_0000115 "Abnormally increased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." ; dc:date "2018-05-01T02:22:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated 6-hydroxypurine phosphoribosyltransferase level", "Elevated 6-mercaptopurine phosphoribosyltransferase level", "Elevated GMP pyrophosphorylase level" ; a owl:Class ; rdfs:label "Elevated hypoxanthine-guanine phosphoribosyltransferase level" ; rdfs:subClassOf obo:HP_0031821 . obo:HP_0031823 obo:IAO_0000115 "Abnormally decreased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." ; dc:date "2018-05-01T02:23:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced 6-hydroxypurine phosphoribosyltransferase level", "Reduced 6-mercaptopurine phosphoribosyltransferase level", "Reduced GMP pyrophosphorylase level" ; a owl:Class ; rdfs:label "Reduced hypoxanthine-guanine phosphoribosyltransferase level" ; rdfs:subClassOf obo:HP_0031821 . obo:HP_0031824 obo:IAO_0000115 "Liver mast cell infiltration." ; dc:date "2018-05-01T02:32:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hepatic mastocytosis" ; rdfs:subClassOf obo:HP_0100495 . obo:HP_0031825 obo:IAO_0000115 "Freezing of gait is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk." ; dc:date "2018-05-02T00:28:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Freezing gait" ; a owl:Class ; rdfs:comment "Freezing of gait is one of the most debilitating motor symptoms in patients with Parkinson's disease as it may lead to falls and a loss of independence. Patients may report that their feet are stuck to the floor as if held by magnets when trying to walk, resulting in a temporary blockage of the motor function involved in ambulation." ; rdfs:label "Freezing of gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031826 obo:IAO_0000115 "Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur)." ; dc:date "2018-05-02T01:05:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal reflex" ; rdfs:subClassOf obo:HP_0100022 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031827 obo:IAO_0000115 "Lack of contraction of abdominal muscles in the quadrant of the abdomen that is stimulated by scraping the skin tangential to or toward the umbilicus." ; dc:date "2018-05-02T01:07:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abdominal reflex absent" ; a owl:Class ; rdfs:comment "A normal abdominal reflex can be observed as a brisk contraction of the umbilicus toward the quadrant that is stimulated. An absent abdominal reflex can point to neurological disease but may also be absent due to other causes such as obesity." ; rdfs:label "Absent abdominal reflex" ; rdfs:subClassOf obo:HP_0031828 . obo:HP_0031828 obo:IAO_0000115 "An anomaly of a reflex that is elicited as a motor response to scraping of the skin. They are generally graded as present or absent. They differ from tendon reflexes in that the sensory signal must ascend the spinal cord to reach the brain and then descend the spinal cord to reach the motor neurons." ; dc:date "2018-05-02T01:09:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal superficial reflex" ; rdfs:subClassOf obo:HP_0031826 . obo:HP_0031829 obo:IAO_0000115 "Lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex." ; dc:date "2018-05-02T01:11:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent cremasteric reflex" ; a owl:Class ; rdfs:label "Absent cremaster reflex" ; rdfs:subClassOf obo:HP_0031828 . obo:HP_0031830 obo:IAO_0000115 "A pinguecula is a yellowish to brown protruding lesion in the conjunctiva that is easily seen on the nasal and temporal sides of the cornea." ; dc:date "2018-05-04T01:54:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pinguecula" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0031831 obo:IAO_0000115 "A reduced concentration of zinc in the blood." ; dc:date "2018-05-04T02:05:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased serum zinc" ; rdfs:subClassOf obo:HP_0008277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031832 obo:IAO_0000115 "Overshoot of downward saccadic eye movements." ; dc:date "2018-05-04T02:38:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypermetric downward saccades" ; rdfs:subClassOf obo:HP_0007338 . obo:HP_0031833 obo:IAO_0000115 "Saccadic undershoot of upward saccadic eye movements, i.e., an upward saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object." ; dc:date "2018-05-04T02:39:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypometric upward saccades" ; rdfs:subClassOf obo:HP_0000571 . obo:HP_0031834 obo:IAO_0000115 "Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus." ; dc:date "2018-05-04T03:10:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aortopulmonary collateral arteries" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0031835 obo:IAO_0000115 "An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." ; dc:date "2018-05-05T12:59:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal superoxide:superoxide oxidoreductase activity" ; a owl:Class ; rdfs:label "Abnormal superoxide dismutase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0031836 obo:IAO_0000115 "Increased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." ; dc:date "2018-05-05T13:01:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased superoxide:superoxide oxidoreductase activity" ; a owl:Class ; rdfs:label "Increased superoxide dismutase level" ; rdfs:subClassOf obo:HP_0031835 . obo:HP_0031837 obo:IAO_0000115 "Decreased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." ; dc:date "2018-05-05T13:01:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased superoxide:superoxide oxidoreductase activity" ; a owl:Class ; rdfs:label "Decreased superoxide dismutase level" ; rdfs:subClassOf obo:HP_0031835 . obo:HP_0031838 obo:IAO_0000115 "Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids." ; dc:date "2018-05-05T13:07:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The presence of a xenobiotic in body tissues or fluids can be the result of ingestion of or exposure to substances such as drugs, environmental pollutants, food additives, hydrocarbons, and pesticides." ; rdfs:label "Presence of xenobiotic" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0031840 obo:IAO_0000115 "The presence of a xenobiotic in urine." ; dc:date "2018-05-05T14:15:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Urine xenobiotic" ; rdfs:subClassOf obo:HP_0031838 . obo:HP_0031841 obo:IAO_0000115 "Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in urine." ; dc:date "2018-05-05T14:18:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Methadone is an opioid drug that is used to treat severe pain or in the treatment of individiuals with opioid dependency." ; rdfs:label "Positive urine methadone test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0031842 obo:IAO_0000115 "Dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma." ; dc:date "2018-05-05T14:44:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lymphangiectasia" ; a owl:Class ; rdfs:label "Lymphangiectasis" ; rdfs:subClassOf obo:HP_0100766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031843 obo:IAO_0000115 "Abnormal slowness of thought processes." ; dc:date "2018-05-05T15:04:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mental slowness", "Slowed thinking", "Slowed thoughts", "Slowness of thought" ; a owl:Class ; rdfs:label "Bradyphrenia" ; rdfs:subClassOf obo:HP_0100543 . obo:HP_0031844 obo:IAO_0000115 "A sense of intense joy or happiness that is beyond what would be expected under the given circumstances." ; dc:date "2018-05-05T15:29:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Euphoria" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0031845 obo:IAO_0000115 "Any deviation from the normal sexual drive or desire for sexual activity." ; dc:date "2018-05-05T15:32:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal libido" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0031846 obo:IAO_0000115 "A break or crush injury of the thigh bone (femur)." ; dc:date "2018-05-05T15:37:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D005264" ; oboInOwl:hasExactSynonym "Femoral fracture" ; a owl:Class ; rdfs:label "Femur fracture" ; rdfs:subClassOf obo:HP_0002823 . obo:HP_0031847 obo:IAO_0000115 "Reduced ability to walk (ambulate) in a backwards direction." ; dc:date "2018-05-05T15:41:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "We walk backward on a daily basis, such as when backing away from the kitchen sink or stepping back from a curb as a swiftly moving bus passes. This task may be particularly difficult for some individuals who can fall as a result of moving or being perturbed in the backward direction. Some individuals with Parkinson disease exhibit this feature." ; rdfs:label "Difficulty walking backward" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031848 obo:IAO_0000115 "An abnormality of gait that can be observed in individuals with dystonic posture in which the individual walks with an extended trunk and flexed arms, while strutting on the toes without the heels touching the floor." ; dc:date "2018-05-05T15:45:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cock-walk gait" ; rdfs:subClassOf obo:HP_0031954 . obo:HP_0031849 obo:IAO_0000115 "A reversal of sleeping habits with a tendency to sleep during the day and to be awake at night." ; dc:date "2018-05-05T15:51:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inverted sleep-wake cycle" ; a owl:Class ; rdfs:label "Sleep-wake inversion" ; rdfs:subClassOf obo:HP_0006979 . obo:HP_0031850 obo:IAO_0000115 "Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood." ; dc:date "2018-05-05T15:58:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal Hct" ; a owl:Class ; rdfs:comment "Note that the hematocrit is one of the measurements that can contribution to the diagnosis of anemia or polycythemia, which is coded separately." ; rdfs:label "Abnormal hematocrit" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0031851 obo:IAO_0000115 "A reduction below the normal ratio of the volume of red blood cells to the total volume of blood." ; dc:date "2018-05-05T15:59:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low hematocrit", "Reduced Hct" ; a owl:Class ; rdfs:label "Reduced hematocrit" ; rdfs:subClassOf obo:HP_0031850 . obo:HP_0031853 obo:IAO_0000115 "Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other." ; dc:date "2018-05-05T18:12:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The word isomerism is also derived from the Greek: iso-meaning equal and meros-meaning part. Isomerism refers to structures that are themselves mirror-imaged. When used in the area of the congenitally malformed heart, the term isomerism has become the conventional description for the situation in which morphologically right structures or morphologically left structures are found on both sides of the body in the same individual." ; rdfs:label "Isomerism" ; rdfs:subClassOf obo:HP_0030853 . obo:HP_0031854 obo:IAO_0000115 "A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures." ; dc:date "2018-05-05T18:13:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Left-sided isomerism" ; a owl:Class ; rdfs:label "Left Isomerism" ; rdfs:subClassOf obo:HP_0031853 . obo:HP_0031855 obo:IAO_0000115 "A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures." ; dc:date "2018-05-05T18:15:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Right-sided isomerism" ; a owl:Class ; rdfs:label "Right isomerism" ; rdfs:subClassOf obo:HP_0031853 . obo:HP_0031856 obo:IAO_0000115 "An abnormal gait characterized by toe walking, stiff legs, and skipping. The gait pattern has some resemblance to cock-walk gait, but affected individuals are able to improve their dystonic gait by walking backward." ; dc:date "2018-05-05T18:27:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hobby horse gait" ; rdfs:subClassOf obo:HP_0031954 . obo:HP_0031857 obo:IAO_0000115 "Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus." ; dc:date "2018-05-05T18:42:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ineffective esophageal motility" ; a owl:Class ; rdfs:comment "Ineffective esophageal motility can be diagnosed by high-resolution manometry if 50% or more swallows are ineffective (failed or weak with the distal contractile integral less than 450 mmHg/s/cm)." ; rdfs:label "Ineffective esophageal peristalsis" ; rdfs:subClassOf obo:HP_0025270, obo:HP_0100771 . obo:HP_0031858 obo:IAO_0000115 "Longitudinal grooves in the surface of the esophagus arranged in a longitudinal fashion (from top to bottom of the esophagus)." ; dc:date "2018-05-05T18:45:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Esophageal furrows may occur in inflammatory disorders of the esophagus such as eosinophilic esophagitis." ; rdfs:label "Esophageal furrows" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0031860 obo:IAO_0000115 "Any abnormality in the variability of the time interval between successive heartbeats." ; dc:date "2018-05-05T21:02:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal heart rate variability" ; rdfs:subClassOf obo:HP_0011675 . obo:HP_0031861 obo:IAO_0000115 "Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle." ; dc:date "2018-05-05T21:03:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced heart rate variability" ; a owl:Class ; rdfs:label "Decreased heart rate variability" ; rdfs:subClassOf obo:HP_0031860 . obo:HP_0031862 obo:IAO_0000115 "Increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle." ; dc:date "2018-05-05T21:05:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased heart rate variability" ; rdfs:subClassOf obo:HP_0031860 . obo:HP_0031863 obo:IAO_0000115 "The presence of an infectious agent in the blood circulation." ; dc:date "2018-05-05T21:12:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Infectious agents can be classified into five groups: viruses, bacteria, fungi, protozoa, and helminths (worms)." ; rdfs:label "Bloodstream infectious agent" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0031864 obo:IAO_0000115 "Presence of viable bacteria in the blood." ; dc:date "2018-05-05T21:13:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bacteria in blood culture", "Bacteria in blood cultures" ; a owl:Class ; rdfs:label "Bacteremia" ; rdfs:subClassOf obo:HP_0031863 . obo:HP_0031865 obo:IAO_0000115 "Any functional anomaly of the liver." ; dc:date "2018-05-05T21:20:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal hepatic physiology" ; a owl:Class ; rdfs:label "Abnormal liver physiology" ; rdfs:subClassOf obo:HP_0001392 . obo:HP_0031866 obo:IAO_0000115 "Clasp-knife phenomonen refers to increased muscle tone while bending or stretching a limb, whereby there is a sudden relaxation (decrease in resistance) as the muscle continues to be streched. This phenomenon has been likened to opening a clasp knife." ; dc:date "2018-05-05T21:28:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Clasp-knife sign" ; rdfs:subClassOf obo:HP_0034353 . obo:HP_0031867 obo:IAO_0000115 "Increased passive stiffness or tightness of the neck musculature." ; dc:date "2018-05-05T21:31:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neck hypertonia" ; rdfs:subClassOf obo:HP_0001276 . obo:HP_0031868 obo:IAO_0000115 "Difficulty reaching to visually guided goals in peripheral vision, with the deficit leaves voluntary eye movements largely unaffected." ; dc:date "2018-05-06T13:12:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Optic ataxia is related to a cortical neurologic deficit that is a result of a lesion to the superior parietal lobule (SPL) and areas around the intraparietal sulcus (IPS). The phenomenon is thought not to be an apraxia (a disorder in executing learned behaviors), but rather a lack of coordination between visual input and motor outputs, and thus the term ataxia, Greek for Lack of Order." ; rdfs:label "Optic ataxia" ; rdfs:subClassOf obo:HP_0011446 . obo:HP_0031869 obo:IAO_0000115 "Dislocation of a given joint repeated times." ; dc:date "2018-05-06T13:19:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Recurrent joint dislocations" ; a owl:Class ; rdfs:label "Recurrent joint dislocation" ; rdfs:subClassOf obo:HP_0001373 . obo:HP_0031870 obo:IAO_0000115 "An elevated concentration of phosphohydroxylysine in the urine." ; dc:date "2018-05-06T13:30:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are no clinical manifestations associated with phosphohydroxylysinuria other than the urinary metabolites." ; rdfs:label "Phosphohydroxylysinuria" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0031871 obo:IAO_0000115 "Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis." ; dc:date "2018-05-06T13:33:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal Langerhans cell morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0031872 obo:IAO_0000115 "Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still not completely understood, although most studies point toward an active role in receptor-mediated endocytosis and participation in the antigen-processing/presenting function of LC. This feature refers to the absence of BG in LC, a feature that can be documented by means of electron microscopy." ; dc:date "2018-05-06T13:41:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent Birbeck granules in Langerhans cells" ; rdfs:subClassOf obo:HP_0031871 . obo:HP_0031873 obo:IAO_0000115 "A tendency towards rising very early in the morning and going to bed early in the evening." ; dc:date "2018-05-06T13:57:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Early sleep onset" ; a owl:Class ; rdfs:label "Early chronotype" ; rdfs:subClassOf obo:HP_0006979 . obo:HP_0031874 obo:IAO_0000115 "A tendency towards rising very late in the morning and going to bed late at night." ; dc:date "2018-05-06T14:03:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Late sleep onset" ; a owl:Class ; rdfs:label "Late chronotype" ; rdfs:subClassOf obo:HP_0006979 . obo:HP_0031875 obo:IAO_0000115 "Any deviation from the normal concentration of hepcidin in the blood circulation." ; dc:date "2018-05-06T14:11:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal hepcidin level" ; a owl:Class ; rdfs:comment "Hepcidin, a 25-amino acid peptide exclusively synthesized by the liver, is the main iron regulatory hormone." ; rdfs:label "Abnormal circulating hepcidin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0031876 obo:IAO_0000115 "Concentration of hepcidin in the blood circulation below the lower limit of normal." ; dc:date "2018-05-06T14:13:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased hepcidin level" ; a owl:Class ; rdfs:label "Decreased circulating hepcidin concentration" ; rdfs:subClassOf obo:HP_0031875 . obo:HP_0031877 obo:IAO_0000115 "Concentration of hepcidin in the blood circulation above the upper limit of normal." ; dc:date "2018-05-06T14:13:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated hepcidin level" ; a owl:Class ; rdfs:label "Elevated circulating hepcidin concentration" ; rdfs:subClassOf obo:HP_0031875, obo:HP_0033331 . obo:HP_0031878 obo:IAO_0000115 "Small hands and feet in proportion to the rest of the body." ; dc:date "2018-05-06T14:37:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acromicria" ; rdfs:subClassOf obo:HP_0002813 . obo:HP_0031879 obo:IAO_0000115 "Any functional abnormality of the eyelid." ; dc:date "2018-05-06T15:39:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal eyelid physiology" ; rdfs:subClassOf obo:HP_0032040 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031880 obo:IAO_0000115 "Abnormally lax eyelid associated with tissue relaxation; it can be demonstrated by the eyelid distraction test and/or the eyelid snap test." ; dc:date "2018-05-06T15:42:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lid laxity" ; a owl:Class ; rdfs:label "Eyelid laxity" ; rdfs:subClassOf obo:HP_0031879 . obo:HP_0031881 obo:IAO_0000115 "A form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct." ; dc:date "2018-05-06T15:54:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased tear drainage" ; rdfs:subClassOf obo:HP_0009926 . obo:HP_0031882 obo:IAO_0000115 "A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm." ; dc:date "2018-05-06T16:11:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Agyria diffuse" ; a owl:Class ; rdfs:label "Agyria" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0031883 obo:IAO_0000115 "An elevated concentration of proinsulin (the prohormone precursor to insulin) to mature insulin in the circulation." ; dc:date "2018-05-07T10:24:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proinsulin:insulin ratio" ; rdfs:subClassOf obo:HP_0011014 . obo:HP_0031884 obo:IAO_0000115 "A deviation from normal concentration of glucose content in the cerebrospinal fluid." ; dc:date "2018-05-13T13:54:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CSF glucose level" ; a owl:Class ; rdfs:label "Abnormal CSF glucose concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0031885 obo:IAO_0000115 "Abnormally high glucose concentration in the cerebrospinal fluid." ; dc:date "2018-05-13T13:55:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased CSF glucose" ; a owl:Class ; rdfs:label "Hyperglycorrhachia" ; rdfs:subClassOf obo:HP_0031884 . obo:HP_0031886 obo:IAO_0000115 "Any deviation from the normal concentration of low-density lipoprotein cholesterol in the blood circulation." ; dc:date "2018-05-13T14:27:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal LDL-C concentration", "Abnormal LDL-C level", "Abnormal LDLc concentration" ; a owl:Class ; rdfs:label "Abnormal LDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010979 . obo:HP_0031887 obo:IAO_0000115 "Any deviation from the normal circulating concentration of chylomicrons." ; dc:date "2018-05-13T14:32:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Chylomicrons are one of the major classes of lipoproteins. Like VLDL, they function to transport triacylglycerol (TAG) in the circulation. Chylomicrons are synthesized in the small intestine by enterocytes from absorbed lipids. Endothelial cells in the circulation can process TAG from chylomicrons by means of the cell-surface enzyme lipoprotein lipase, which digests the TAG to fatty acids and monoglycerides." ; rdfs:label "Abnormal chylomicron concentration" ; rdfs:subClassOf obo:HP_0010979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042627 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031888 obo:IAO_0000115 "Any deviation from the normal concentration of high-density lipoprotein cholesterol (HDL) in the blood." ; dc:date "2018-05-13T14:42:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "HDL returns excess cholesterol from cells to the liver via various pathways." ; rdfs:label "Abnormal HDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031889 obo:IAO_0000115 "Any deviation from the normal concentration of very-low-density lipoprotein cholesterol in the blood." ; dc:date "2018-05-13T14:47:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "VLDL is synthesized in the liver and is involved in the transport of triacylglycerol (TAG) to the body." ; rdfs:label "Abnormal VLDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0010979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_47773 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031890 obo:IAO_0000115 "An elevated concentration of urobilinogen in the urine." ; dc:date "2018-05-13T20:23:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Urobilinogen is formed from the reduction of bilirubin. An increased amount of urobilinogen in the urine may be indicative of liver disease." ; rdfs:label "Increased urine urobilinogen" ; rdfs:subClassOf obo:HP_0032472 . obo:HP_0031891 obo:IAO_0000115 "Abnormal reduction in the count of eosinophils in the blood per volume." ; dc:date "2018-05-13T20:35:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased eosinophil count" ; rdfs:subClassOf obo:HP_0020064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031898 obo:IAO_0000115 "Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells." ; dc:date "2018-05-19T15:09:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased rouleaux formation" ; a owl:Class ; rdfs:label "Rouleaux formation" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0031899 obo:IAO_0000115 "Any deviation from the activity of coagulation factor V." ; dc:date "2018-05-19T15:11:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal factor V activity" ; a owl:Class ; rdfs:comment "Factor V is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex." ; rdfs:label "Abnormal coagulation factor V activity" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0031900 obo:IAO_0100001 "HP:0031901" ; dc:date "2018-05-19T15:14:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal serum tryptase concentration" ; owl:deprecated true . obo:HP_0031901 obo:IAO_0000115 "An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation." ; dc:date "2018-05-19T15:17:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0031900" ; a owl:Class ; rdfs:comment "Tryptase is a serine protease that is primarily produced and stored in mast cells (MCs) and less abundantly in blood basophils [31-34]. In tissue MCs, tryptase is produced and released in a constitutive manner, regardless of the organ, location of MCs, maturation stage or subtype of MCs. Mature tissue MCs also store larger quantities of the enzyme in their metachromatic granules. Two major forms of tryptase are produced in MCs, alpha-tryptase and beta-tryptase. Whereas the alpha form is produced and released constantly in MCs, the beta-form is primarily stored in MC granules. During an anaphylactic reaction, MCs rapidly release substantial amounts of alpha- and beta tryptases. Current tests measure total tryptase (alpha and beta), not differentiating between these isoforms. The presence of elevated tryptase may occur acutely due to mast cell degranulation. Alternatively, chronic elevation of basal serum tryptase may be present in individuals with: 1) clonal myeloid neoplasms; 2) the genetic trait hereditary alpha-tryptasemia; 3) chronic kidney disease. Serum tryptase levels are useful in the diagnosis of mast cell activation, clonal myeloid disease, and hereditary alpha-tryptasemia." ; rdfs:label "Elevated total serum tryptase" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0031902 dc:date "2018-05-19T15:17:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:consider "HP:0031901" ; a owl:Class ; rdfs:comment "Clinically, there is no abnormal reduction in tryptase activity and thus this term was incorrect and should not be used." ; rdfs:label "obsolete Decreased serum mast cell beta-tryptase concentration" ; owl:deprecated true . obo:HP_0031903 obo:IAO_0000115 "Any deviation from the normal circulating concentration of selenium." ; dc:date "2018-05-19T15:19:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serum selenium concentration" ; a owl:Class ; rdfs:comment "Selenium (Se) is an essential micronutrient that exists in the form of selenocysteine (Sec), the 21st amino acid, upon its incorporation into selenoproteins via the tRNA[Sec] encoded by Trsp. Dietary intake of the micronutrient selenium is essential for normal immune functions. Selenium is cotranslationally incorporated as the 21st amino acid, selenocysteine, into selenoproteins that function to modulate pathways involved in inflammation." ; rdfs:label "Abnormal circulating selenium concentration" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0031904 obo:IAO_0000115 "Any deviation from the normal total hemolytic complement activity in the circulation." ; dc:date "2018-05-19T15:22:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CH50" ; a owl:Class ; rdfs:comment "The total hemolytic complement test, also known as the CH50, is a screening test for total complement activity." ; rdfs:label "Abnormal total hemolytic complement activity" ; rdfs:subClassOf obo:HP_0005339 . obo:HP_0031905 obo:IAO_0000115 "An abnormally elevated total hemolytic complement activity in the circulation." ; dc:date "2018-05-19T15:27:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased total hemolytic complement activity" ; rdfs:subClassOf obo:HP_0031904 . obo:HP_0031906 obo:IAO_0000115 "An abnormally reduced total hemolytic complement activity in the circulation." ; dc:date "2018-05-19T15:27:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased total hemolytic complement activity" ; rdfs:subClassOf obo:HP_0031904 . obo:HP_0031907 obo:IAO_0000115 "The presence of M2 anti-mitochondrial antibody (immunoglobulins) in the serum." ; dc:date "2018-05-19T15:34:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "AMA-M2 positive" ; oboInOwl:hasNarrowSynonym "Anti-pyruvate dehydrogenase antibody positivity" ; a owl:Class ; rdfs:comment "Anti-mitochondrial antibody (AMA) can be tested via indirect immunofluorescence. AMAs are biomarkers of primary biliary cirrhosis (PBC) and can also be found in patients with idiopathic inflammatory myopathies. The auto-antigens of AMA have been identified as pyruvate dehydrogenase complex-E2 (PDC-E2), branched-chain 2-oxo acid dehydrogenase complex and 2-oxoglutaric acid dehydrogenase complex. The antibody to these antigens is known as AMA-M2. AMA-M2 is more specific to PBC than AMA, and the determination of its titer is feasible" ; rdfs:label "Anti-mitochondrial M2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0031908 obo:IAO_0000115 "Abnormally small sized handwriting defined formally as an impairment of a fine motor skill manifesting mainly as a progressive or stable reduction in amplitude during a writing task." ; dc:date "2018-05-19T15:50:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Micrographia" ; rdfs:subClassOf obo:HP_0011446 . obo:HP_0031909 obo:IAO_0000115 "A uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn." ; dc:date "2018-06-23T13:42:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A unicornuate uterus with a rudimentary horn is an anomaly caused by defective fusion of one of the paired Mullerian ducts. The incidence of rudimentary-horn pregnancy is estimated to be one in 76,000 pregnancies. Life-threateningly heavy bleeding and abortion are the anticipated outcomes of rudimentary horn pregnancies. According to the literature, the newborn survival rate is between 0-13 percent in pregnancies in the rudimentary horn, with only one third of such gestations reaching term or beyond. Slightly more than half of the pregnancies ended with a rupture of the pregnant uterine horn." ; rdfs:label "Unicornuate uterus" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0031910 obo:IAO_0000115 "A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem." ; dc:date "2018-06-23T13:49:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cranial nerve physiology" ; rdfs:subClassOf obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031911 dc:date "2018-06-23T13:55:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fifth cranial nerve physiology" ; rdfs:subClassOf obo:HP_0031910 . obo:HP_0031912 obo:IAO_0000115 "Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth." ; dc:date "2018-06-23T13:56:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trigeminal anaesthesia" ; a owl:Class ; rdfs:label "Trigeminal anesthesia" ; rdfs:subClassOf obo:HP_0031911 . obo:HP_0031913 obo:IAO_0000115 "Rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis." ; dc:date "2018-06-23T17:46:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Rhombencephalosynapsis occurs in isolation or in combination with other CNS and extra-CNS malformations. The most common congenital anomaly syndrome associated with RES is Gomez-Lopez-Hernandez syndrome." ; rdfs:label "Rhombencephalosynapsis" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0031914 obo:IAO_0000115 "Varying irregularly over time in severity, amount, or amplitude." ; dc:date "2018-07-01T21:29:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fluctuating" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0031915 obo:IAO_0000115 "This modifier can be applied to a phenotypic feature that does not vary in severity or amount over time." ; dc:date "2018-07-01T21:31:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Stable" ; rdfs:subClassOf obo:HP_0011008 . obo:HP_0031917 obo:IAO_0000115 "An open sore on the surface of the skin of a finger or toe." ; dc:date "2018-07-02T00:51:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Digital ulcers are a common manifestation of systemic sclerosis, and can be responsible for substantial pain and mobidity." ; rdfs:label "Digital ulcer" ; rdfs:subClassOf obo:HP_0200042 . obo:HP_0031918 obo:IAO_0000115 "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts." ; dc:date "2018-07-02T10:46:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ovarian sex cord-stromal tumour" ; a owl:Class ; rdfs:label "Ovarian sex cord-stromal tumor" ; rdfs:subClassOf obo:HP_0100615 . obo:HP_0031919 obo:IAO_0000115 "Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occuring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type." ; dc:date "2018-07-02T10:52:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Juvenile type ovarian granulosa cell tumour", "Ovarian juvenile granulosa cell tumor", "Ovarian juvenile granulosa cell tumour" ; a owl:Class ; rdfs:label "Juvenile type ovarian granulosa cell tumor" ; rdfs:subClassOf obo:HP_0031918 . obo:HP_0031920 obo:IAO_0000115 "An aggressive granulosa cell tumor that arises from the ovary." ; dc:date "2018-07-02T11:18:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Malignant ovarian granulosa cell tumour" ; a owl:Class ; rdfs:label "Malignant ovarian granulosa cell tumor" ; rdfs:subClassOf obo:HP_0100615 . obo:HP_0031921 obo:IAO_0000115 "Pain of the gastrocnemius muscle." ; dc:date "2018-07-04T11:57:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Calf muscle pain", "Calf myalgia" ; a owl:Class ; rdfs:comment "The gastrocnemius is located together with the soleus muscle in the calf of the leg. Gastrocnemius myalgia refers to pain and tenderness in this muscle with a course of weeks or months or more. Gastrocnemius myalgia is a rarely observed initial manifestion of Crohn disease." ; rdfs:label "Gastrocnemius myalgia" ; rdfs:subClassOf obo:HP_0003326 . obo:HP_0031922 obo:IAO_0000115 "The renal arteries carry blood from the aorta to the kidney; normally one renal artery is present on each side of the body. Renal artery duplication refers to the presence of two rather than one renal artery on a given side of the body." ; dc:date "2018-07-04T12:09:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Accessory renal artery", "Double renal artery" ; a owl:Class ; rdfs:comment "Double renal arteries with aortic origin is a benign condition representing the persistence of the embryonic vessels, the lateral branches of the mesonephros, within the renal ascent. The embryonic urogenital ridge from which the kidneys develop is supplied by several paired arteries: the rete arteriosum urogenitale. The later developing metanephric kidneys retain only a single pair of mesonephric arteries, however a variable number may persist." ; rdfs:label "Renal artery duplication" ; rdfs:subClassOf obo:HP_0008776 . obo:HP_0031923 obo:IAO_0000115 "Accumulation of blood in the vagina usually due to vaginal obstruction." ; dc:date "2018-07-04T12:19:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Haematocolpos" ; a owl:Class ; rdfs:label "Hematocolpos" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0031924 obo:IAO_0000115 "The presence of linear erythematous palpable cords, often on the lateral trunk." ; dc:date "2018-07-04T12:31:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Its associations include connective tissue disease (particularly SLE), rheumatoid arthritis, autoimmune thyroiditis, carcinomas and drug reactions. Histology reveals an interstitial and palisading granulomatous dermatitis associated with piecemeal fragmentation of collagen and elastic fibres" ; rdfs:label "Rope sign" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0031925 obo:IAO_0000115 "A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub." ; dc:date "2018-07-04T13:22:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Rosettes are named for the flower-like architectural ornament, this pattern resembles the rose windows found in many gothic cathedrals. Rosettes may be considered primary or secondary manifestations of tumor architecture. Primary rosettes form as a characteristic growth pattern of a given tumor type, whereas secondary rosettes result from the influence of external factors on tumor growth." ; rdfs:label "Rosette" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0031926 obo:IAO_0000115 "A type of rosette in which the central lumen or hub is filled with fiber-like processes." ; dc:date "2018-07-04T13:24:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The delicate fibrillary material found within the central lumen of the Homer Wright rosette is composed of neuropil, which contains primitive neuronal processes or neurites. The typical Homer Wright rosette with its central lumen or hub filled with fiber-like processes can also be found in medulloblastomas and histologically similar tumors occurring outside of the cerebellum, designated PNETs." ; rdfs:label "Homer Wright rosette" ; rdfs:subClassOf obo:HP_0031925 . obo:HP_0031927 obo:IAO_0000115 "The tumor cells that form the Flexner-Wintersteiner rosette circumscribe a central lumen that contains small cytoplasmic extensions of the encircling cells; however, unlike the center of the Homer Wright rosette, the central lumen does not contain the fiber-rich neuropil." ; dc:date "2018-07-04T13:26:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A type of rosette in which a halo of cells surrounds a largely empty central hub. Small cytoplasmic extensions from the cells project into the lumen." ; rdfs:label "Flexner-Wintersteiner rosette" ; rdfs:subClassOf obo:HP_0031925 . obo:HP_0031928 obo:IAO_0000115 "A type of rosette in which a halo of cells surrounds an empty lumen." ; dc:date "2018-07-04T13:28:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to the Homer Wright and the Flexner-Wintersteiner rosettes, the empty-appearing lumen of the true ependymal rosette resembles a tubule lumen and contains no fiber-rich neuropil or central cytoplasmic projections. These tubule-like structures, as well as more elongated versions known as ependymal canals, may represent an attempt by the tumor cells to recapitulate the formation of ventricles with ependymal linings." ; rdfs:label "True ependymal rosette" ; rdfs:subClassOf obo:HP_0031925 . obo:HP_0031929 obo:IAO_0000115 "A type of rosette in which a spoke-wheel arrangement of cells with tapered cellular processes radiates around a wall of a centrally placed vessel." ; dc:date "2018-07-04T13:30:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The modifier pseudo differentiates this pattern from the Homer Wright and Flexner-Wintersteiner rosettes, perhaps because the central structure is not actually formed by the tumor itself, but instead represents a native, non-neoplastic element. Also, some early investigators argued about the definition of a central lumen, choosing pseudo to indicate that the hub was not a true lumen but contained structures. Nevertheless, this pattern remains extremely diagnostically useful and the modifier unnecessarily leads to confusion. Perivascular pseudorosettes are encountered in most ependymomas regardless of grade or variant." ; rdfs:label "Perivascular pseudorosette" ; rdfs:subClassOf obo:HP_0031925 . obo:HP_0031930 obo:IAO_0000115 "A type of rosette that is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular." ; dc:date "2018-07-04T13:32:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pineocytomatous rosette" ; a owl:Class ; rdfs:comment "Pineocytomas and central neurocytomas represent well-differentiated neuronal neoplasms with small rounded nuclei, analogous to those normally encountered in the internal granular layer of the cerebellum or the dentate fascia of the hippocampus. Although they likely originate from slightly different precursors, the histologic features of these two tumors are virtually identical, including their tendency to form neuropil-rich rosettes, referred to as pineocytomatous rosettes in pineocytomas and neurocytic rosettes in central neurocytoma" ; rdfs:label "Neurocytic rosette" ; rdfs:subClassOf obo:HP_0031925 . obo:HP_0031931 obo:IAO_0000115 "Ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behaviour and its occurrence may be favoured by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation." ; dc:date "2018-07-04T20:01:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ocular flutter" ; rdfs:subClassOf obo:HP_0012547, obo:HP_0032104 . obo:HP_0031932 obo:IAO_0000115 "Aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left or right ventricular cavity." ; dc:date "2018-07-04T20:38:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Left ventricle to aorta tunnel" ; a owl:Class ; rdfs:comment "ALVT is extremely rare with incidence as low as 0.001% of all congenital heart diseases. Most of the patients develop symptoms of heart failure during the first year of life. The onset, severity and progression of heart failure vary and ranges from in-utero fetal death to asymptomatic adulthood." ; rdfs:label "Aorto-left ventricular tunnel" ; rdfs:subClassOf obo:HP_0011627 . obo:HP_0031933 obo:IAO_0000115 "The presence of an extracardiac channel that connects the ascending aorta above the sinotubular junction to the cavity of the right ventricle." ; dc:date "2018-07-04T20:40:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Right ventricle to aorta tunnel" ; a owl:Class ; rdfs:label "Aorto-right ventricular tunnel" ; rdfs:subClassOf obo:HP_0011627 . obo:HP_0031934 obo:IAO_0000115 "A structural abnormality of the part of the aorta that begins at the aortic arch and then descends through the chest and abdomen." ; dc:date "2018-07-04T20:44:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal descending aorta morphology" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0031935 obo:IAO_0000115 "Significant luminal narrowing of a long segment of or the entire ascending aorta." ; dc:date "2018-07-04T20:46:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Coarctation of the aorta is defined as significant luminal narrowing of the aorta that produces hemodynamically significant obstruction to the flow of blood. This process may affect a short isolated segment of the aorta or a longer and more diffuse segment. When longer segments of the aorta are narrowed, the term hypoplasia is often used. Much less common than segmental coarctation, aortic hypoplasia has been described in all portions of the thoracic and abdominal aorta." ; rdfs:label "Ascending aorta hypoplasia" ; rdfs:subClassOf obo:HP_0031784 . obo:HP_0031936 obo:IAO_0000115 "A failure to achieve the ability to walk at an appropriate developmental stage. Most children learn to walk in a series of stages, and learn to walk short distances independently between 12 and 15 months." ; dc:date "2018-07-04T21:00:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Delayed walking" ; a owl:Class ; rdfs:label "Delayed ability to walk" ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0031937 obo:IAO_0000115 "Fast speech." ; dc:date "2018-07-04T21:09:19Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Tachylogia" ; a owl:Class ; rdfs:label "Tachylalia" ; rdfs:subClassOf obo:HP_5200011 . obo:HP_0031938 obo:IAO_0000115 "Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae)." ; dc:date "2018-07-05T13:09:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal conus medullaris morphology" ; a owl:Class ; rdfs:comment "The tapering end of the conus terminalis continues as the filum terminale." ; rdfs:label "Abnormal conus terminalis morphology" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0031939 dc:date "2018-07-05T13:14:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries with location in the conus terminalis." ; rdfs:label "Conus terminalis arteriovenous malformation" ; rdfs:subClassOf obo:HP_0031938 . obo:HP_0031941 obo:IAO_0000115 "Any structural anomaly of the portal venous sytem, which comprises all of the veins draining the abdominal part of the digestive tract, including the lower esophagus but excluding the lower anal canal. The portal vein conveys blood from viscera and ramifies like an artery at the liver, ending at the sinusoids. Tributaries of the portal vein, which make up the portal venous system, are the splenic, superior mesenteric, left gastric, right gastric, paraumbilical, and cystic veins." ; dc:date "2018-07-05T13:39:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal portal venous system morphology" ; rdfs:subClassOf obo:HP_0006707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031942 obo:IAO_0000115 "Anomaly where the intestinal and the splenic venous drainage bypass the liver and drain into systemic veins through other possible venous shunts." ; dc:date "2018-07-05T13:42:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CAPV", "Missing portal vein" ; a owl:Class ; rdfs:label "Congenital absence of portal vein" ; rdfs:subClassOf obo:HP_0031941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031943 obo:IAO_0000115 "A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria." ; dc:date "2018-07-05T13:57:19Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Akathisia" ; rdfs:subClassOf obo:HP_0000711 . obo:HP_0031944 obo:IAO_0000115 "An increase in the thickness of the pleura, generally related to scarring of the pleural tissue." ; dc:date "2018-07-05T14:02:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pleural incrassation" ; a owl:Class ; rdfs:label "Pleural thickening" ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0031945 obo:IAO_0000115 "An increased concentration of N,N-dimethylglycine in the circulation." ; dc:date "2018-07-06T11:54:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated N,N-dimethylglycine level" ; a owl:Class ; rdfs:comment "An important metabolic pathway for choline involves its conversion into glycine via betaine aldehyde, betaine, N,N-dimethylglycine (DMG),1 and sarcosine. DMG is converted into sarcosine and sarcosine is converted into glycine by two oxidative demethylation steps mediated by DMG dehydrogenase (DMGDH; EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1), respectively. An increased concentration of DMG of DMG can caused by a deficiency of the enzyme dimethylglycine dehydrogenase (DMGDH), which normally catalyzes the conversion of DMG into sarcosine as well as the conversion of sarcosine into glycine." ; rdfs:label "Elevated circulating N,N-dimethylglycine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0031946 obo:IAO_0000115 "An increased concentration of N,N-dimethylglycine in the urine." ; dc:date "2018-07-06T11:59:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary N,N-dimethylglycine level" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0031947 obo:IAO_0000115 "An unintentional, oscillating to-and-fro muscle movement affecting the tongue." ; dc:date "2018-07-06T12:11:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Jerky movements of the tongue" ; a owl:Class ; rdfs:label "Tongue tremor" ; rdfs:subClassOf obo:HP_0030188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031948 obo:IAO_0000115 "Centrally located corpus callosum hyperintensities said to resemble snowballs upon magnetic resonance imaging (with T2 or Sagittal fluid attenuated inversion recovery [FLAIR] sequences). The central location in the callosum makes them pathognomonic for Susac syndrome." ; dc:date "2018-07-06T12:16:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Snowball lesion of corpus callosum" ; rdfs:subClassOf obo:HP_0001273 . obo:HP_0031949 obo:IAO_0000115 "An increased susceptibility to bacterial upper respiratory tract infections as manifested by a history of recurrent bacterial upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis)." ; dc:date "2018-07-06T12:24:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Recurrent bacterial URI" ; a owl:Class ; rdfs:label "Recurrent bacterial upper respiratory tract infections" ; rdfs:subClassOf obo:HP_0002788 . obo:HP_0031950 obo:IAO_0000115 "Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing." ; dc:date "2018-07-06T12:27:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Usual interstitial pneumonia (UIP) is usually identified by a honeycombing pattern in a CT scan; in contrast, diffuse interstitial pneumonia (DIP) is not associated with the honeycombing pattern of fibrotic tissue. DIP tends to stabilize or improve after treatment, UIP often continues to progress (irregular lines or honeycombing). Honeycombing, clustered cysts with well-defined walls involving the subpleural lung, is the key finding for making a definite diagnosis of UIP pattern. UIP is associated with autoimmune diseases such as rheumatoid arthritis (and rheumatoid arthritis-interstitial lung disease, or RA-ILD)." ; rdfs:label "Usual interstitial pneumonia" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0031951 obo:IAO_0000115 "Seizures that occur while the affected individual is sleeping." ; dc:date "2018-07-07T12:33:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sleep seizures" ; a owl:Class ; rdfs:label "Nocturnal seizures" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0031952 obo:IAO_0000115 "Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine." ; dc:date "2018-07-07T13:44:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neurogenic claudication" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031953 obo:IAO_0000115 "Cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen." ; dc:date "2018-07-07T13:46:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Senile gait" ; a owl:Class ; rdfs:label "Cautious gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031954 obo:IAO_0000115 "Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients." ; dc:date "2018-07-07T13:48:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dystonic gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031955 obo:IAO_0000115 "To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position." ; dc:date "2018-07-07T13:50:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Limp" ; a owl:Class ; rdfs:label "Antalgic gait" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0031956 obo:IAO_0000115 "An abnormally high concentration in the circulation of aspartate aminotransferase (AST)." ; dc:date "2018-07-07T13:54:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aspartate aminotransferase increased", "Elevated serum AST", "Elevated serum aspartate aminotransferase", "Elevated serum glutamic oxaloacetic transaminase" ; a owl:Class ; rdfs:label "Elevated circulating aspartate aminotransferase concentration" ; rdfs:subClassOf obo:HP_0002910 . obo:HP_0031957 obo:IAO_0000115 "Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster." ; dc:date "2018-07-07T14:01:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Wernicke-Mann gait" ; a owl:Class ; rdfs:label "Spastic hemiparetic gait" ; rdfs:subClassOf obo:HP_0002064 . obo:HP_0031958 obo:IAO_0000115 "A type of spastic gait in which the legs are usually slightly bent at the hip and in an adducted position. The knees are extended or slightly bent and the feet are in a plantar flexion position. This posture requires circumduction of the legs during walking. The gait may appear stiff (spastic gait disorder) or stiff as well as insecure (spastic ataxic gait disorder). In spastic paraparetic gait, each leg appears to be dragged forward. If the muscle tone in the adductors is marked, the resulting gait disorder is referred to as scissor gait." ; dc:date "2018-07-07T14:02:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spastic paraparetic gait" ; rdfs:subClassOf obo:HP_0002064 . obo:HP_0031959 obo:IAO_0000115 "A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs." ; dc:date "2018-07-07T14:23:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Leg dystonia" ; rdfs:subClassOf obo:HP_0002451 . obo:HP_0031960 obo:IAO_0000115 "A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the arms." ; dc:date "2018-07-07T14:24:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arm dystonia" ; rdfs:subClassOf obo:HP_0002451 . obo:HP_0031961 obo:IAO_0000115 "Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration." ; dc:date "2018-07-07T14:27:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The determination of the anion gap is used in the detection and analysis of acid-base disorders, assessment of quality control in the chemical laboratory, and detection of such disorders as multiple myeloma, bromide intoxication, and lithium intoxication. The normal value can vary widely, reflecting both differences in the methods that are used to measure its constituents and substantial interindividual variability." ; rdfs:label "Abnormal serum anion gap" ; rdfs:subClassOf obo:HP_0004360 . obo:HP_0031962 obo:IAO_0000115 "An abnormally high value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration)." ; dc:date "2018-07-07T14:29:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Elevated values of the serum anion gap most commonly indicate metabolic acidosis but can reflect laboratory error, metabolic alkalosis, hyperphosphatemia, or paraproteinemia. Metabolic acidosis can be divided into high anion and normal anion gap varieties, which can be present alone or concurrently." ; rdfs:label "Elevated serum anion gap" ; rdfs:subClassOf obo:HP_0031961 . obo:HP_0031963 obo:IAO_0000115 "An abnormally low value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration)." ; dc:date "2018-07-07T14:31:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Low values of the serum anion gap most commonly indicate laboratory error or hypoalbuminemia but can denote the presence of a paraproteinemia or intoxication with lithium, bromide, or iodide." ; rdfs:label "Decreased serum anion gap" ; rdfs:subClassOf obo:HP_0031961 . obo:HP_0031964 obo:IAO_0000115 "An abnormally high concentration in the circulation of alanine aminotransferase (ALT)." ; dc:date "2018-07-07T14:37:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Alanine aminotransferase increased", "Elevated serum ALT", "Elevated serum alanine aminotransferase", "Elevated serum glutamic-pyruvic transaminase" ; a owl:Class ; rdfs:comment "Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells." ; rdfs:label "Elevated circulating alanine aminotransferase concentration" ; rdfs:subClassOf obo:HP_0002910 . obo:HP_0031965 obo:IAO_0000115 "Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage." ; dc:date "2018-07-07T14:42:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased red blood cell distribution width" ; a owl:Class ; rdfs:comment "Although RDW has been traditionally used in the investigation of the etiology of anemia there is an increasing evidence linking elevated RDW with poor outcome in general population [4, 5], in patients with coronary artery disease, with metabolic syndrome and heart failure." ; rdfs:label "Increased RBC distribution width" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0031967 obo:IAO_0000115 "The appearance of the urine having visible material in suspension, i.e., appearing cloudy." ; dc:date "2018-07-07T23:20:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Turbid urine" ; a owl:Class ; rdfs:comment "Cloudy appearance of urine may be related to the presence of bacteria, blood, sperm, crystals, or mucus." ; rdfs:label "Cloudy urine" ; rdfs:subClassOf obo:HP_0033072 . obo:HP_0031969 obo:IAO_0000115 "An abnormally low concentration of urea nitrogen in the blood." ; dc:date "2018-07-07T23:28:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced BUN" ; a owl:Class ; rdfs:label "Reduced blood urea nitrogen" ; rdfs:subClassOf obo:HP_0031970 . obo:HP_0031970 obo:IAO_0000115 "Any deviation from the normal concentration of urea nitrogen in the blood." ; dc:date "2018-07-07T23:29:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal BUN concentration" ; a owl:Class ; rdfs:label "Abnormal blood urea nitrogen concentration" ; rdfs:subClassOf obo:HP_0004364 . obo:HP_0031971 obo:IAO_0000115 "A localized hypertrophy of the subaortic segment of the ventricular septum has been frequently described in elderly persons, and variously termed subaortic ventricular septal bulge (VSB), sigmoid-shaped septum, localized or discrete upper septal hypertrophy." ; dc:date "2018-07-07T23:58:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Subaortic ventricular septal bulge has been considered mainly as an incidental finding associated with older age and hypertension, although some authors have suggested that it may be part of the spectrum of hypertrophic cardiomyopathy, may determine some degree of left ventricular (LV) obstruction, which in turn may potentially cause symptoms such as syncope and dyspnea on effort." ; rdfs:label "Subaortic ventricular septal bulge" ; rdfs:subClassOf obo:HP_0011103 . obo:HP_0031972 obo:IAO_0000115 "Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause." ; dc:date "2018-07-08T00:03:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Presyncope" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0031973 obo:IAO_0000115 "An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disc." ; dc:date "2018-07-08T00:08:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Primary open angle glaucoma is causing a progressive optic neuropathy and its development is associated with loss of tissue in the neuroretinal rim of the optic disc and that will lead to increase in the size of the optic cup. Clinical estimation of the size of the cup using either the slit lamb or a simple imaging modalities such as fundus images is a significant clinical parameter and remains the simplest and most frequently performed assessment of the optic disc in the diagnosis and follows up the progression of the glaucoma suspect. The estimation of the size of the cup is usually made by comparison with the size of the disc and given as the ratio of the vertical and horizontal diameter of the cup to the vertical and horizontal diameter." ; rdfs:label "Increased vertical cup-to-disc ratio" ; rdfs:subClassOf obo:HP_0012796 . obo:HP_0031974 obo:IAO_0000115 "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.6 (The normal cup-to-disc ratio is 0.3)." ; dc:date "2018-07-08T00:13:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased vertical cup-to-disc ratio - 0.6" ; rdfs:subClassOf obo:HP_0031973 . obo:HP_0031975 obo:IAO_0000115 "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.7 (The normal cup-to-disc ratio is 0.3)." ; dc:date "2018-07-08T00:15:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased vertical cup-to-disc ratio - 0.7" ; rdfs:subClassOf obo:HP_0031973 . obo:HP_0031976 obo:IAO_0000115 "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.8 (The normal cup-to-disc ratio is 0.3)." ; dc:date "2018-07-08T00:15:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased vertical cup-to-disc ratio - 0.8" ; rdfs:subClassOf obo:HP_0031973 . obo:HP_0031977 obo:IAO_0000115 "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.9 (The normal cup-to-disc ratio is 0.3)." ; dc:date "2018-07-08T00:15:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased vertical cup-to-disc ratio - 0.9" ; rdfs:subClassOf obo:HP_0031973 . obo:HP_0031978 obo:IAO_0000115 "Ratio of the height of the cup of the optic nerve head to the height of the disc is 1.0 (The normal cup-to-disc ratio is 0.3)." ; dc:date "2018-07-08T00:15:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased vertical cup-to-disc ratio - 1.0" ; rdfs:subClassOf obo:HP_0031973 . obo:HP_0031979 obo:IAO_0000115 "Any deviation from the normal concentration of a carbohydrate in the urine." ; dc:date "2018-07-08T12:53:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Carbohydrates, also known as saccharides, comprise mono-, d-, and oligosaccharides (substances from endogenous metabolism or from exogenous sources such as diet). Most saccharides except glucose are readily excreted in the urine, reflecting dieteray consuption. Increased sacchardie levels may indicate an enzyme defect or other disease if a certain type of saccharide or a certain profile is found." ; rdfs:label "Abnormal urine carbohydrate level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0031980 obo:IAO_0000115 "Any deviation from the normal concentration of a carboxylic acid in the urine." ; dc:date "2018-07-08T13:01:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Carboxylic acid refers to an organic compound that contains a carboxyl group (-COOH)." ; rdfs:label "Abnormal urine carboxylic acid level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0031981 obo:IAO_0000115 "An increased concentration of glycolate in the urine." ; dc:date "2018-07-08T13:03:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Primary hyperoxaluria type 1 is an inborn error of glyoxalate metabolism characterized by excessive production and urinary excretion of oxalate and glycolate." ; rdfs:label "Elevated urine glycolate" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0031982 obo:IAO_0000115 "Any structural anomaly of the putamen, a brain nucleus which together with the caudate nucleus and fundus striati makes up the striatum." ; dc:date "2018-07-08T13:26:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal putamen morphology" ; rdfs:subClassOf obo:HP_0010994 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0031983 obo:IAO_0000115 "This term groups terms representing abnormal findings derived from chest X-ray investigation of the lung. In general, lung abnormalities can manifest as opacities (areas of increased density) or as regions with decreased density." ; dc:date "2018-07-08T13:38:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal chest radiograph finding (lung)" ; a owl:Class ; rdfs:label "Abnormal pulmonary thoracic imaging finding" ; rdfs:subClassOf obo:HP_0012252 . obo:HP_0031984 obo:IAO_0000115 "A piece of food that has gotten stuck in the esophagus and prevents further swallowing." ; dc:date "2018-07-08T14:55:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Although any type of food can become stuck in the esophagus, in the adult population, structural diseases or abnormalities of the esophagus, specifically eosinophilic esophagitis, are the main causes of food impactions. Eosinophilic esophagitis causes solid food to become stuck in the esophagus intermittently." ; rdfs:label "Esophageal food impaction" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0031985 obo:IAO_0000115 "An exudate is a mass of fluid and cells that has seeped out of blood vessels or an organ, usually related to inflammation. In the esophagus, exudates usually present as whitish plagues on the surface of the esophageal mucosa." ; dc:date "2018-07-08T14:58:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophageal exudate" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0031986 obo:IAO_0000115 "Irregular, small-amplitude myoclonic movements of the hands and/or fingers on keeping outstretched posture (jerky postural tremor). Polyminimyoclonus is stimulus-sensitive and accentuated during voluntary movements. A cortical origin can be demonstrated by back-averaging techniques, and somatosensory evoked potentials (SSEPs) are sometimes giant." ; dc:date "2018-07-09T01:38:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polyminimyoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0031987 obo:IAO_0000115 "Being unable to focus one's attention or mental effort on a particular object or activity." ; dc:date "2018-07-09T01:48:46Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Concentration problems", "Lack of concentration", "Poor concentration" ; a owl:Class ; rdfs:label "Diminished ability to concentrate" ; rdfs:subClassOf obo:HP_5200044 . obo:HP_0031988 obo:IAO_0100001 "HP:0003394" ; a owl:Class ; rdfs:label "obsolete Muscle spasm" ; owl:deprecated true . obo:HP_0031989 obo:IAO_0000115 "A sudden involuntary contraction of the musculature surrounding the mouth." ; dc:date "2018-07-09T14:40:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perioral spasm" ; rdfs:subClassOf obo:HP_0003394 . obo:HP_0031990 obo:IAO_0000115 "A contraction of ipsilateral facial muscles subsequent to percussion over the facial nerve." ; dc:date "2018-07-09T14:41:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The Chvostek sign is considered to be a clinical indicator of hypocalcemia." ; rdfs:label "Chvostek sign" ; rdfs:subClassOf obo:HP_0004305 . obo:HP_0031991 obo:IAO_0000115 "An increased concentration of beta-1-galactosyl-O-hydroxylysine (Gal-Hyl) in the urine. This is a biochemical marker of bone resorption." ; dc:date "2018-07-09T15:24:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary excretion of galactosyl hydroxylysine" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0031992 obo:IAO_0000115 "Apical hypertrophic cardiomyopathy (AHCM) is diastolic dysfunction due to abnormal stiffness of the left ventricle during diastole, with resultant impaired ventricular filling. In AHCM thickened apical segments produce a crowded, spade-shaped, small apical cavity." ; dc:date "2018-07-09T15:40:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Apical hypertrophic cardiomyopathy" ; rdfs:subClassOf obo:HP_0001639 . obo:HP_0031993 obo:IAO_0000115 "A Hoffmann test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test." ; dc:date "2018-07-15T18:58:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hoffmann's sign" ; a owl:Class ; rdfs:comment "The Hoffmann sign is regarded to be test for disease of the corticospinal pathways." ; rdfs:label "Hoffmann sign" ; rdfs:subClassOf obo:HP_0007256 . obo:HP_0031994 obo:IAO_0000115 "Bronchial breath sounds contain much higher frequency components than normal breath sounds due to alteration of the low pass filtering function of the alveoli, as occurs in consolidation. It is loud, hollow, and high pitch. Expiratory phase is longer than inspiratory phase with the inspiratory-expiratory ratio (I:E) changing from normal 3:1 to 1:2. There is distinct pause between inspiration and expiration due to absent alveolar phase. It is associated with whispering pectoriloquy." ; dc:date "2018-07-15T19:45:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchial breath sound" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0031995 obo:IAO_0000115 "Squawks are short inspiratory wheezes of less than 200 ms duration and are also known as squeaks. Acoustic analysis shows the fundamental frequency varying between 200 and 300 Hz. Squawks usually occur in late inspiration and are often preceded by late inspiratory crackles." ; dc:date "2018-07-15T19:48:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Squawks are found in pulmonary fibrosis of various causes, particularly in hypersensitivity pneumonitis. Other causes are detected in pneumonia and bronchiolitis obliterans." ; rdfs:label "Squawks" ; rdfs:subClassOf obo:HP_0030828 . obo:HP_0031996 obo:IAO_0000115 "Crackles that are heard during the inspiratory phase." ; dc:date "2018-07-15T21:46:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inspiratory crackles" ; rdfs:subClassOf obo:HP_0030830 . obo:HP_0031997 obo:IAO_0000115 "Crackles that appear at the beginning of inspiration and end before mid-inspiration." ; dc:date "2018-07-15T21:47:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Early inspiratory crackles may be observed, for example, in chronic obstructive pulmonary disease (COPD). Crackles in COPD patients are scanty, gravity-independent, usually audible at the mouth, and strongly associated with severe airway obstruction. Crackles start early in inspiration and usually end before the midpoint of inspiration." ; rdfs:label "Early inspiratory crackles" ; rdfs:subClassOf obo:HP_0031996 . obo:HP_0031998 obo:IAO_0000115 "Crackles that appear any time after the beginning of inspiration and last till the end of inspiration." ; dc:date "2018-07-15T21:49:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Late inspiratory crackles may be observed, for example, in diffuse parenchymal lung disease (DPLD). Crackles are commonly seen in patients with IPF/usual interstitial pneumonia (UIP), asbestosis, and desquamative interstitial pneumonia (DIP)." ; rdfs:label "Late inspiratory crackles" ; rdfs:subClassOf obo:HP_0031996 . obo:HP_0031999 obo:IAO_0000115 "Crackles that occur during expiration." ; dc:date "2018-07-15T21:50:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Crackles are predominantly inspiratory in nature, but can also occur during expiration. It has been described in COPD, bronchiectasis, and IPF. One theory of the pathogenesis of expritory crackles states that some airways collapse during early expiration and air trapping develops. As expiration progresses, the pressure in the trapped region gradually increase, leading to a widened pressure difference across the airways. Once this pressure difference reaches the critical opening pressure, the airway pops open during expiration, producing crackles." ; rdfs:label "Expiratory crackles" ; rdfs:subClassOf obo:HP_0030830 . obo:HP_0032000 obo:IAO_0000115 "An abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles" ; dc:date "2018-07-15T21:53:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleural rub" ; rdfs:subClassOf obo:HP_0030829 . obo:HP_0032001 obo:IAO_0000115 "An abnormal pink color of urine." ; dc:date "2018-07-15T21:57:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pink urine color may indicate blood or be a consequence of the ingestion of certain food such as beets, blackberries and rhubarb." ; rdfs:label "Pink urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0032002 obo:IAO_0000115 "An abnormal orange color of urine." ; dc:date "2018-07-15T21:59:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orange urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0032003 obo:IAO_0000115 "An abnormal green color of urine." ; dc:date "2018-07-15T22:05:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Green urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0032004 obo:IAO_0000115 "A sensation of itching in the vulvar region." ; dc:date "2018-07-15T22:20:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pruritus vulvae" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0032005 obo:IAO_0000115 "Hemidystonia refers to dystonia which involves the ipsilateral face, arm, and leg." ; dc:date "2018-07-17T12:51:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In most cases of hemidystonia, a contralateral structural lesion of the basal ganglia or thalamus can be demonstrated by neuroimaging. Common aetiologies include stroke and trauma, and younger patients seem to have a greater propensity to develop hemidystonia after cerebral insults. There is often a latency between cerebral injury and the onset of dystonia. Hemidystonia may be preceded by ipsilateral hemiparesis which often resolves as hemidystonia develops." ; rdfs:label "Hemidystonia" ; rdfs:subClassOf obo:HP_0001332 . obo:HP_0032006 obo:IAO_0000115 "An unintentional, oscillating to-and-fro muscle movement affecting the lip." ; dc:date "2018-07-17T13:06:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lip tremor" ; rdfs:subClassOf obo:HP_0030188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000589 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032007 obo:IAO_0000115 "A softening and breaking down of skin resulting from prolonged exposure to moisture. Macerated skin becomes soft and wrinkly and takes on a whitish hue." ; dc:date "2018-07-17T13:09:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maceration of the skin", "Skin maceration" ; a owl:Class ; rdfs:label "Maceration" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0032008 obo:IAO_0000115 "The release of fat globules into the venous circulation, thereby blocking blood circulation to the lung." ; dc:date "2018-07-17T13:39:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fat embolism" ; a owl:Class ; rdfs:label "Pulmonary fat embolism" ; rdfs:subClassOf obo:HP_0002204 . obo:HP_0032009 obo:IAO_0000115 "Constant exotropia occurring before 6 months of age.; often associated with a large angle of deviation and ocular/CNS abnormalities." ; dc:date "2018-07-22T15:37:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Infantile (constant) exotropia" ; a owl:Class ; rdfs:comment "Typically infantile constant exotropia suggests presentation at 6 months of age or younger, while basic constant exotropia suggests later presentation (older than 6-12 months). (OHO 745 & 750)." ; rdfs:label "Infantile constant exotropia" ; rdfs:subClassOf obo:HP_0031713 . obo:HP_0032010 obo:IAO_0000115 "Constant exotropia for near and distance, presenting after 6 months of age." ; dc:date "2018-07-22T15:39:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Basic (constant) exotropia" ; a owl:Class ; rdfs:comment "Typically infantile constant exotropia suggests presentation at 6 months of age or younger, while basic constant exotropia suggests later presentation (older than 6-12 months). (OHO 745 & 750)." ; rdfs:label "Basic constant exotropia" ; rdfs:subClassOf obo:HP_0031713 . obo:HP_0032011 obo:IAO_0000115 "Heterophorias are latent deviations that are controlled by fusion. In certain circumstances (specific visual tasks, fatigue, illness, etc.), fusion can no longer be maintained and decompensation occurs." ; dc:date "2018-07-22T15:44:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to heterophoria, heterotropias are manifest deviations. Some individuals may be phoric in one situation (e.g. for distance) and tropic in another (e.g. for near). The distinction between heterotropia and heterophoria is that heterotropia refers to a misalignment of the eyes when the affected individual is looking at an object while the eyes are uncovered whereas heterophoria is a misalignment that is observed only when the two eyes are no longer looking at the same object. The monocular cover-uncover test is the most important test for detecting the presence of manifest strabismus and for differentiating a heterophoria from a heterotropia." ; rdfs:label "Heterophoria" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0032012 obo:IAO_0000115 "Manifest deviation of the visual axes not controlled by fusion." ; dc:date "2018-07-22T15:46:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The distinction between heterotropia and heterophoria is that heterotropia refers to a misalignment of the eyes when the affected individual is looking at an object while the eyes are uncovered whereas heterophoria is a misalignment that is observed only when the two eyes are no longer looking at the same object. The monocular cover-uncover test is the most important test for detecting the presence of manifest strabismus and for differentiating a heterophoria from a heterotropia." ; rdfs:label "Heterotropia" ; rdfs:subClassOf obo:HP_0000486 . obo:HP_0032013 obo:IAO_0000115 "Overshoot of horizontal (sideways) saccadic eye movements." ; dc:date "2018-07-22T16:28:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypermetric horizontal saccades" ; rdfs:subClassOf obo:HP_0007338 . obo:HP_0032014 obo:IAO_0000115 "Inaccurate saccades (rapid movement of the eye between fixation points) in the vertical direction." ; dc:date "2018-07-22T16:29:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dysmetric vertical saccades" ; rdfs:subClassOf obo:HP_0000641 . obo:HP_0032015 obo:IAO_0000115 "Inaccurate saccades (rapid movement of the eye between fixation points) in the horizontal direction." ; dc:date "2018-07-22T16:33:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dysmetric horizontal saccades" ; rdfs:subClassOf obo:HP_0000641 . obo:HP_0032016 obo:IAO_0000115 "Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin." ; dc:date "2018-08-25T12:36:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal sputum morphology" ; a owl:Class ; rdfs:label "Abnormal sputum" ; rdfs:subClassOf obo:HP_0012252 . obo:HP_0032017 obo:IAO_0000115 "An increased proportion of eosinophils in sputum in the differentiated cell count." ; dc:date "2018-08-25T12:39:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sputum eosinophilia can be measured in various ways including measuing the mean percentage of eosinophils in the cell count of sputum induced by application of saline. The threshold chosen differs between studies, typically ranging from 1.25 to 3 percent. Increased sputum eosinophil counts may indicate a risk for severe chronic obstructive pulmonary disease or severe asthma." ; rdfs:label "Sputum eosinophilia" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0032018 obo:IAO_0000115 "A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially." ; dc:date "2018-08-25T15:36:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mononeuritis multiplex" ; a owl:Class ; rdfs:comment "Mononeuritis multiplex can be a manifestation of several disorders including infectious, inflammatory, neoplastic, toxic, metabolic and hereditary conditions." ; rdfs:label "Multiple mononeuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0032019 obo:IAO_0000115 "Eosinophil infiltration of skeletal muscle." ; dc:date "2018-08-25T15:42:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic infiltration of skeletal muscle" ; a owl:Class ; rdfs:comment "This phenotype can be measured by determining the number and location of eosinophils in skeletal muscle biopsies by Giemsa and modified hematoxylin/eosin staining. However, infiltrating eosinophils are not always identified in conventional muscle histologic examination, but the eosinophil major basic protein, whose extracellular diffusion is considered a hallmark of eosinophilic cytotoxicity, is usually detected by immunostaining in muscle biopsy." ; rdfs:label "Muscle eosinophilia" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0032020 obo:IAO_0000115 "Transmural inflammation of the bladder predominantly with eosinophils, associated with fibrosis with or without muscle necrosis." ; dc:date "2018-08-25T15:48:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic cystitis" ; a owl:Class ; rdfs:label "Eosinophilic bladder infiltration" ; rdfs:subClassOf obo:HP_0025487 . obo:HP_0032021 obo:IAO_0000115 "Cellular infiltration of the liver parenchyma with a preponderance of eosinophils." ; dc:date "2018-08-25T15:51:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Eosinophilic hepatitis" ; a owl:Class ; rdfs:label "Eosinophilic liver infiltration" ; rdfs:subClassOf obo:HP_0030146, obo:HP_0032064 . obo:HP_0032022 obo:IAO_0000115 "Presence of abnormally increased amounts of intraepidermal inflammatory cells with a predominance of eosinophils." ; dc:date "2018-09-01T13:38:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic dermatitis" ; a owl:Class ; rdfs:label "Eosinophilic dermal infiltration" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0032023 obo:IAO_0000115 "Cellular infiltrate confirmed by a cellular infiltrate comprised of mainly eosinophils in the gallbladder wall on histological examination." ; dc:date "2018-09-01T13:49:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic cholecystitis" ; a owl:Class ; rdfs:label "Eosinophilic gallbladder infiltration" ; rdfs:subClassOf obo:HP_0012437, obo:HP_0032064 . obo:HP_0032024 obo:IAO_0000115 "An erosion of the mucous membrane in a portion of the ileum." ; dc:date "2018-09-01T14:06:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ileal ulcer" ; rdfs:subClassOf obo:HP_0001549, obo:HP_0034274 . obo:HP_0032025 obo:IAO_0000115 "A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs." ; dc:date "2018-09-01T14:16:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced serum alpha-1-antitrypsin" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032026 obo:IAO_0000115 "Circumscribed area of flaccid skin due to the loss of elastic tissue in the dermis." ; dc:date "2018-09-01T14:38:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anetoderma is a skin disorder characterized by focal loss of dermal elastic tissue. Clinically, it can present as various types of flaccid skin, such as protruding (raised), indented (depressed), or flat." ; rdfs:label "Anetoderma" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0032027 obo:IAO_0000115 "Yellow, white or greyish lesions in the retina that are well-defined/distinct, individual and mostly uniform in size." ; dc:date "2018-09-01T14:43:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Retinal dots" ; rdfs:subClassOf obo:HP_0030506 . obo:HP_0032028 obo:IAO_0000115 "Yellow, white or greyish lesions in the macula that are well-defined/distinct, individual and mostly uniform in size." ; dc:date "2018-09-01T14:44:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Macular dots" ; rdfs:subClassOf obo:HP_0030500 . obo:HP_0032029 obo:IAO_0000115 "Excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis." ; dc:date "2018-09-01T14:47:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Floppy eyelid" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032030 obo:IAO_0000115 "Laxity of the tendon stabilising the lateral aspect of the tarsal plate to the zygomatic bone. This can result in rounded appearence of the lateral canthus. Also, when the eyelid is pulled medially, more than 2 mm movement of the canthal angle may be observed." ; dc:date "2018-09-01T14:49:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral canthal tendon laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032031 obo:IAO_0000115 "Laxity of the tendon stabilising the medial aspect of the tarsal plate to the anterior and posterior lacrimal crests. This may lead to more than 2mm movement of the punctum when the eyelid is pulled laterally." ; dc:date "2018-09-01T14:50:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial canthal tendon laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032032 obo:IAO_0000115 "Abnormally lax eyelid associated with tissue relaxation, predominantly in the horizontal plane. It can be demonstrated by the horizontal eyelid distraction test (e.g. by pulling the eyelid medially and laterally). Medial and/or lateral canthal tendon laxity are often present." ; dc:date "2018-09-01T14:51:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Horizontal eyelid laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032033 obo:IAO_0000115 "Abnormally lax eyelid associated with tissue relaxation, predominantly in the vertical plane. It can be demonstrated by vertical lid pull. Loosening of vertical stabilising structures (e.g. lower lid retractors) or tarsal atrophy are often present." ; dc:date "2018-09-01T14:52:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vertical eyelid laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032034 obo:IAO_0000115 "Abnormally lax upper eyelid associated with tissue relaxation." ; dc:date "2018-09-01T14:52:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Upper eyelid laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032035 obo:IAO_0000115 "Abnormally lax lower eyelid associated with tissue relaxation." ; dc:date "2018-09-01T14:53:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lower eyelid laxity" ; rdfs:subClassOf obo:HP_0031880 . obo:HP_0032036 obo:IAO_0000115 "An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target. Contrast-sensitivity measurements differ from acuity measurements; acuity is a measure of the spatial-resolving ability of the visual system under conditions of very high contrast, whereas contrast sensitivity is a measure of the threshold contrast for seeing a target." ; dc:date "2018-09-01T15:21:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal contrast sensitivity" ; a owl:Class ; rdfs:label "Reduced contrast sensitivity" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0032037 obo:IAO_0000115 "Mild reduction of the ability to see defined as visual acuity less than 6/12 (20/40 in US notation; 0.5 in decimal notation) but at least 6/18 (20/63 in US notation; 0.32 in decimal notation)." ; dc:date "2018-09-01T15:45:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mild reduction in visual acuity", "Mild vision loss", "Mild visual loss" ; a owl:Class ; rdfs:comment "A visual acuity of 6/6 signifies that a person can see symbols such as those on a Snellen chart from six meters the same as a person with normal eyesight. A visual acuity of 6/12 signifies that the person can see symbols at 6 meters the same as a person with normal eyesight could at 12 meters." ; rdfs:label "Mildly reduced visual acuity" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0032039 obo:IAO_0000115 "An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." ; dc:date "2018-09-03T00:17:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of the ocular adnexa" ; rdfs:subClassOf obo:HP_0000315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0035639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032040 obo:IAO_0000115 "A functional anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." ; dc:date "2018-09-03T00:18:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ocular adnexa physiology" ; rdfs:subClassOf obo:HP_0032039 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0035639 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032041 obo:IAO_0000115 "A small growth on a vocal cord that may appear as pedunculated or sessile and have varying size, shape, and color." ; dc:date "2018-09-08T01:50:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In severe conditions, polyps turn hemorrhagic and emerge as blood blisters on vocal cords. This occurs when collision forces, generated during the oscillatory cycle of phonation, cause microtrauma within the basement membrane of epithelium and the superficial layer of the lamina propria. Consequently, oscillation of vocal folds leads to neovascularization and hemorrhagic events within the damaged tissue. Depending on the size, position, and type of polyps, abnormal voice qualities including hoarseness, harshness, and breathiness would be different. The size of polyps varies from small to large masses, and a criterion to distinguish polyps from nodules is defined as mass bigger than 0.3 mm whereby bigger masses could be classified as polyps." ; rdfs:label "Vocal cord polyp" ; rdfs:subClassOf obo:HP_0008777 . obo:HP_0032043 obo:IAO_0000115 "Pain experienced with swallowing." ; dc:date "2018-09-16T10:35:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Painful swallowing" ; a owl:Class ; rdfs:label "Odynophagia" ; rdfs:subClassOf obo:HP_0012719 . obo:HP_0032044 obo:IAO_0000115 "A reduction in the ability to maintain sustained attention characterized by reduced alertness." ; dc:date "2018-09-16T10:41:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased vigilance" ; rdfs:subClassOf obo:HP_0004372 . obo:HP_0032045 obo:IAO_0000115 "Underdevelopment of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse." ; dc:date "2018-09-16T10:47:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypoplastic carotid canal" ; rdfs:subClassOf obo:HP_0009911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006668 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032046 obo:IAO_0000115 "A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons." ; dc:date "2018-09-16T10:55:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Focal cortical dysplasia is one of the most common entities associated with refractory epilepsy, especially in childhood." ; rdfs:label "Focal cortical dysplasia" ; rdfs:subClassOf obo:HP_0002539 . obo:HP_0032047 obo:IAO_0000115 "A type of focal cortical dysplasia that is characterized by abnormal cortical layering." ; dc:date "2018-09-16T11:00:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type I" ; rdfs:subClassOf obo:HP_0032046 . obo:HP_0032048 obo:IAO_0000115 "A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination." ; dc:date "2018-09-16T11:03:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type Ia" ; rdfs:subClassOf obo:HP_0032047 . obo:HP_0032049 obo:IAO_0000115 "A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination." ; dc:date "2018-09-16T11:05:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type Ib" ; rdfs:subClassOf obo:HP_0032047 . obo:HP_0032050 obo:IAO_0000115 "A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination." ; dc:date "2018-09-16T11:06:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type Ic" ; rdfs:subClassOf obo:HP_0032049 . obo:HP_0032051 obo:IAO_0000115 "A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities." ; dc:date "2018-09-16T11:09:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type II" ; rdfs:subClassOf obo:HP_0032046 . obo:HP_0032052 obo:IAO_0000115 "A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins." ; dc:date "2018-09-16T11:11:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are no balloon cells present (to be confirmed by immunohistochemistry). Discrimination of individual cortical layers is almost impossible (with the exception of Layer 1). Other cortical layer abnormalities are frequently encountered and should not be separately classified, including abnormal isocortical layer organization adjacent to the main lesion, as well as heterotopic neurons in Layer 1 or white matter." ; rdfs:label "Focal cortical dysplasia type IIa" ; rdfs:subClassOf obo:HP_0032051 . obo:HP_0032053 obo:IAO_0000115 "A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells." ; dc:date "2018-09-16T11:12:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cortical lamination is frequently disrupted with the exception of Layer 1. The myelin content may also be altered in underlying subcortical white matter. Other cortical layer abnormalities are frequently encountered and should not be separately classified, including abnormal isocortical layer organization adjacent to the main lesion, as well as heterotopic neurons in Layer 1 or white matter. Histopathologically similar lesions are observed in cortical tubers and other gross MCDs, i.e. hemimegalencephaly or schizencephaly." ; rdfs:label "Focal cortical dysplasia type IIb" ; rdfs:subClassOf obo:HP_0032051 . obo:HP_0032054 obo:IAO_0000115 "A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe." ; dc:date "2018-09-16T11:15:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type III" ; rdfs:subClassOf obo:HP_0032046 . obo:HP_0032055 obo:IAO_0000115 "A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organisation (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (also known as Ammon's horn sclerosis)." ; dc:date "2018-09-16T11:16:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type IIIa" ; rdfs:subClassOf obo:HP_0032054 . obo:HP_0032056 obo:IAO_0000115 "A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor." ; dc:date "2018-09-16T11:18:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This type of focal cortical dysplasia is associated with glial or glioneuronal tumors (Ganglioglioma, Dysembryoplastic Neuroepithelial Tumor (DNT, syn. DNET) or other epilepsy-associated neoplasms. It is important to exclude tumor infiltration in areas of cortical abnormalities before establishing the diagnosis of FCD. The etiology and pathogenesis of FCD Type IIIb remains to be determined, but is likely an acquired process." ; rdfs:label "Focal cortical dysplasia type IIIb" ; rdfs:subClassOf obo:HP_0032054 . obo:HP_0032057 obo:IAO_0000115 "A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis)." ; dc:date "2018-09-16T11:23:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type IIIc" ; rdfs:subClassOf obo:HP_0032054 . obo:HP_0032058 obo:IAO_0000115 "A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections." ; dc:date "2018-09-16T11:25:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cortical dysplasia type IIId" ; rdfs:subClassOf obo:HP_0032054 . obo:HP_0032059 obo:IAO_0000115 "A malformation of cortical development characterized by mild abnormalities of the cortex: excessive heterotopic neurons in Layer 1 or microscopic neuronal clusters or excess of single neurons of normal morphology in deep white matter." ; dc:date "2018-09-16T11:35:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mild malformation of cortical development" ; rdfs:subClassOf obo:HP_0002539 . obo:HP_0032060 obo:IAO_0000115 "A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area." ; dc:date "2018-09-16T11:50:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Angiolymphoid hyperplasia with eosinophilia" ; a owl:Class ; rdfs:comment "Epithelioid hemangioma is most common in middle-aged adults." ; rdfs:label "Epithelioid hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0032061 obo:IAO_0000115 "A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter." ; dc:date "2018-09-16T11:54:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypereosinophilia" ; rdfs:subClassOf obo:HP_0001880 . obo:HP_0032062 obo:IAO_0000115 "Vomiting-induced mucosal laceration at the esophago-gastric junction." ; dc:date "2018-09-16T12:01:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mallory-Weiss tear" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0032063 obo:IAO_0000115 "Abnormal accumulation of fluid in or around the ankle joint." ; dc:date "2018-09-16T12:08:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ankle joint effusion" ; rdfs:subClassOf obo:HP_0034673 . obo:HP_0032064 obo:IAO_0000115 "Eosinophilic infiltration of one or more gastrointestinal organs. Gastrointestinal eosinophilia is a broad term for abnormal eosinophil accumulation in the GI tract, involving many different disease identities. These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in HES and all gastrointestinal eosinophilic states associated with known causes. Each of these diseases has its unique features but there is no absolute boundary between them." ; dc:date "2018-09-16T12:23:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic enteritis", "Eosinophilic gastroenteritis", "GI eosinophilia" ; oboInOwl:hasRelatedSynonym "Eosinophilic gastrointestinal disease", "Eosinophilic gastrointestinal disorders" ; a owl:Class ; rdfs:label "Gastrointestinal eosinophilia" ; rdfs:subClassOf obo:HP_0012718 . obo:HP_0032065 obo:IAO_0000115 "Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation." ; dc:date "2018-09-23T14:32:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serum HCO3 concentration" ; a owl:Class ; rdfs:comment "Bicarbonate represents the second largest category of anions in plasma. The measurement of bicarbonate also captures carbonate (CO3[-2]) ions, carbon dioxide in solution, and carbamino compounds but the latter represent a tiny fraction of the total measured amount." ; rdfs:label "Abnormal serum bicarbonate concentration" ; rdfs:subClassOf obo:HP_0004360 . obo:HP_0032066 obo:IAO_0000115 "An abnormal reduction of the concentration of bicarbonate, HCO3[-], in the circulation." ; dc:date "2018-09-23T14:36:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased serum HCO3 concentration" ; a owl:Class ; rdfs:label "Decreased serum bicarbonate concentration" ; rdfs:subClassOf obo:HP_0032065 . obo:HP_0032067 obo:IAO_0000115 "An abnormal increase in the concentration of bicarbonate, HCO3[-], in the circulation." ; dc:date "2018-09-23T14:36:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated serum HCO3 concentration" ; a owl:Class ; rdfs:label "Elevated serum bicarbonate concentration" ; rdfs:subClassOf obo:HP_0032065 . obo:HP_0032068 obo:IAO_0000115 "An increased amount of urinary mucus. A small amount of mucus is produced by mucous membrane epithelial cells of the urinary tract. An increased amount of mucus can be detected upon urinalysis or other assays and may indicate conditions such as urinary tract infection, urinary tract reconstruction involving the use of bowel segments, or contamination of the urine sample prior to urinalysis." ; dc:date "2018-09-30T14:35:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary mucus" ; rdfs:subClassOf obo:HP_0033072 . obo:HP_0032069 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin." ; dc:date "2018-09-30T14:43:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-thyroid globulin antibody positivity", "TgAbs" ; a owl:Class ; rdfs:comment "The autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto's thyroiditis (HT) are most common endocrine disorders in humans. Both disorders are characterized by lymphocytic infiltration of the thyroid gland and the production of autoantibodies (aAb) against proteins that are thyroid-specific or expressed predominantly in the thyroid. The three main autoantigens are thyroperoxidase (TPO), thyroglobulin (Tg), and thyrotropin hormone receptor." ; rdfs:label "Anti-thyroglobulin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032070 obo:IAO_0000115 "Contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis." ; dc:date "2018-09-30T15:02:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Contrast material enhancement for cross-sectional imaging in computed tomography and magnetic resonance imaging can be related to intravascular (vascular) enhancement and interstitial (extravascular) enhancement." ; rdfs:label "Leptomeningeal enhancement" ; rdfs:subClassOf obo:HP_0010651 . obo:HP_0032071 obo:IAO_0000115 "The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia." ; dc:date "2018-09-30T15:15:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic pulmonary infiltration", "Pulmonary eosinophilic infiltrate", "Pulmonary eosinophilic infiltration" ; oboInOwl:hasRelatedSynonym "Pulmonary eosinophilia" ; a owl:Class ; rdfs:comment "Pulmonary function testing usually reveals a restrictive process with reduced diffusion capacity for carbon monoxide. Laboratory tests typical include increased levels of eosinophils in the blood, a high erythrocyte sedimentation rate, iron deficiency anemia, and increased platelets." ; rdfs:label "Eosinophilic pneumonia" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0032072 obo:IAO_0000115 "A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle." ; dc:date "2018-10-13T11:41:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Baker's cyst" ; a owl:Class ; rdfs:comment "Popliteal synovial cysts, also known as Baker's cysts, are commonly found in association with intraarticular knee disorders, such as osteoarthritis and meniscus tears. Histologically, the cyst walls resemble synovial tissue with fibrosis, and chronic nonspecific inflammation may be present. Osteocartilaginous loose bodies may also be found within the cyst, even if they are not seen in the knee joint. Baker cysts can be a source of posterior knee pain that persists despite surgical treatment of the intraarticular lesion, and they are routinely discovered on magnetic resonance imaging scans of the symptomatic knee. Symptoms related to a popliteal cyst origin are infrequent and may be related to size." ; rdfs:label "Popliteal synovial cyst" ; rdfs:subClassOf obo:HP_0034669 . obo:HP_0032073 obo:IAO_0000115 "Aplasia, that is failure to develop, of the fallopian tube." ; dc:date "2018-10-13T11:45:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia of the fallopian tube" ; rdfs:subClassOf obo:HP_0008655 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032075 obo:IAO_0000115 "Fusion of the pancreatic tail and spleen." ; dc:date "2018-10-13T12:42:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Splenopancreatic fusion" ; rdfs:subClassOf obo:HP_0012090, obo:HP_0025408 . obo:HP_0032076 dc:date "2018-10-14T13:36:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal male urethral meatus morphology" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0032077 obo:IAO_0000115 "An abnormal narrowing of the urethral opening (meatus) of the penis." ; dc:date "2018-10-14T13:40:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Meatal stenosis", "Meatus stenosis" ; a owl:Class ; rdfs:comment "If the sex is not indicated, meatal stenosis is generally taken to refer to males, and thus we list this term as an exact synonym." ; rdfs:label "Male urethral meatus stenosis" ; rdfs:subClassOf obo:HP_0008661, obo:HP_0032076 . obo:HP_0032078 obo:IAO_0000115 "A phalangeal malformation that is termed angel-shaped phalanx (ASP), because of its resemblance to the angels used for decoration of Christmas trees. The various components of an angel-shaped phalanx are: diaphyseal cuff (wings), surrounding a meta-diaphyseal core (body), which may appear empty or structured with a cone-shaped epiphysis (skirt) and pseudoepiphysis (head)." ; dc:date "2018-10-14T13:49:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In some cases an ASP can grow into an inconspicuous brachydactyly after physeal closure." ; rdfs:label "Angel-shaped phalanx" ; rdfs:subClassOf obo:HP_0005918 . obo:HP_0032079 obo:IAO_0000115 "Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections." ; dc:date "2018-10-14T14:47:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial degeneration" ; rdfs:subClassOf obo:HP_0001679 . obo:HP_0032081 obo:IAO_0000115 "A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix does not significantly alter the arrangement of the lamellar units." ; dc:date "2018-10-14T14:53:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intralamellar mucoid extracellular matrix accumulation" ; rdfs:subClassOf obo:HP_0200146 . obo:HP_0032082 obo:IAO_0000115 "A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix alters the arrangement of the lamellar units to varying degrees." ; dc:date "2018-10-14T14:53:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Translamellar mucoid extracellular matrix accumulation" ; rdfs:subClassOf obo:HP_0200146 . obo:HP_0032083 obo:IAO_0000115 "Loss and/or fragmentation of elastic fibers of the media of the aorta creating increasingly extended translamellar spaces, with absence of elastic fibers, and increased gaps in elastic fiber lamellae as identified on a stain for elastic fibers." ; dc:date "2018-10-14T14:56:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic elastic fibre fragmentation" ; a owl:Class ; rdfs:label "Aortic elastic fiber fragmentation" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032084 obo:IAO_0000115 "A thinning out of elastic fibers of the media of the aorta that creates widening of intralamellar spaces, as identified on a stain for elastic fibers." ; dc:date "2018-10-14T14:57:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic elastic fibre thinning" ; a owl:Class ; rdfs:comment "A healthy aorta has dense elastic fibers comprising each lamella. This term describes the elastic network as being thinned at each lamella with narrower and more frayed apart elastic fibers. This entity may be associated with an increase in extracellular matrix material in the lamellar unit. The use of an elastic stain is essential to identify this lesion." ; rdfs:label "Aortic elastic fiber thinning" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032085 obo:IAO_0000115 "Nonparallel arrangement/disarray of elastic fibers of the media of the aorta as identified on a stain for elastic fibers." ; dc:date "2018-10-14T14:58:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic elastic fibre disorganisation" ; a owl:Class ; rdfs:comment "This rarer process is distinct from fragmentation and loss as the fibers acquire a more haphazard, poorly organized appearance, with loss of the usual parallel/concentric arrangement of elastic fibers within the lamellar unit. This finding is noticeable when at high power, and the orientation of the lamellar units parallel to the aortic lumen is lost. The use of an elastic stain is essential to identify this lesion. Disorganization of elastic fibers can be seen in conjunction with smooth muscle cell disorganization. A poorly oriented aortic specimen may appear to have disorganization and should not be confused with the real entity. This rarer entity should be commented upon, when present as it represents a more severe feature of medial degeneration, but is not essential for routine surgical pathology reporting." ; rdfs:label "Aortic elastic fiber disorganization" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032086 obo:IAO_0000115 "A region of the aortic media in which smooth muscle cell nuclei, involving multiple lamellae, are not clearly identifiable on an hematoxylin and eosin stain." ; dc:date "2018-10-14T15:00:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Smooth muscle cell nuclei loss replaces terms such as medionecrosis and smooth muscle cell necrosis that implied a loss of smooth muscle cells. While the loss of a nucleus suggests the loss of the entire cell, this is not easily appreciated on an hematoxylin and eosin stain stain. The shorter term smooth muscle cell loss was also considered by the consensus group and had many proponents, but the addition of nuclei was ultimately favored by the majority mostly as a histologic definition. Smooth muscle cell nuclei can be lost in patches or can be lost in a band-like pattern. This lesion can be noted in the absence of laminar medial collapse, described below. Both stains highlighting collagen and SMA immunohistochemistry can be used to highlight smooth muscle cell changes." ; rdfs:label "Aortic smooth muscle cell nuclei loss" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032087 obo:IAO_0000115 "Architecturally, a compaction of aortic medial elastic fibers that creates thinning of the lamellar unit secondary to a band-like smooth muscle cell loss identified using a stain for elastic fibers." ; dc:date "2018-10-14T15:03:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Laminar medial collapse replaces the old term laminar medial necrosis and is to be used only when an elastic stain has demonstrated elastic fiber compaction. Laminar medial collapse appears as a darker band on an elastic stain as a result of a significant loss of intermixed smooth muscle cells." ; rdfs:label "Aortic laminar medial collapse" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032088 obo:IAO_0000115 "Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells." ; dc:date "2018-10-14T15:04:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic smooth muscle cell disorganisation" ; a owl:Class ; rdfs:label "Aortic smooth muscle cell disorganization" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032089 obo:IAO_0000115 "An increase in collagen fibers creating areas of substitutive fibrosis or a widening of intralamellar spaces in the media of the aorta. This can be seen in conjunction with a loss to varying degrees of parallel arrangement of the elastic lamellae (or lamellar units)." ; dc:date "2018-10-14T15:05:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aortic medial fibrosis" ; rdfs:subClassOf obo:HP_0032079 . obo:HP_0032090 obo:IAO_0000115 "A type of aortic medial fibrosis in which the increase in collagen does not significantly alter the arrangement of the lamellar units." ; dc:date "2018-10-14T15:08:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intralamellar aortic medial fibrosis" ; rdfs:subClassOf obo:HP_0032089 . obo:HP_0032091 obo:IAO_0000115 "A type of aortic medial fibrosis in which the increase in collagen is more scar-like, altering the arrangement of the lamellar units." ; dc:date "2018-10-14T15:08:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Translamellar aortic medial fibrosis" ; rdfs:subClassOf obo:HP_0032089 . obo:HP_0032092 obo:IAO_0000115 "Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle." ; dc:date "2018-10-14T15:15:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Common causes of left ventricular outflow tract (LVOT) obstruction include subaortic stenosis, bicupsid aortic valve, supravalvar aortic stenosis, coarctation of the aorta, and hypertrophic cardiomyopathy. Note that we reserve this term to describe the physiological abnormality, and denote the morphological abnormalities that lead to LVOT obstruction in the corresponding Morphology sections of the HPO." ; rdfs:label "Left ventricular outflow tract obstruction" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0032094 obo:IAO_0000115 "An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis." ; dc:date "2018-11-04T10:03:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased serum surfactant protein level" ; a owl:Class ; rdfs:comment "SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. But the measure in the blood is not reliable, in this case the measurement in the broncho-alveolar lavage fluid is informative." ; rdfs:label "Increased circulating surfactant protein level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032096 obo:IAO_0000115 "A deviation from the normal range of manganese in the blood circulation." ; dc:date "2018-11-04T11:11:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal manganese concentration" ; rdfs:subClassOf obo:HP_0010927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0055071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032097 obo:IAO_0000115 "An elevation above the normal concentration of manganese in the blood." ; dc:date "2018-11-04T11:12:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased blood manganese concentration" ; a owl:Class ; rdfs:label "Hypermanganesemia" ; rdfs:subClassOf obo:HP_0032096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0055071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032098 obo:IAO_0000115 "A reduction below the normal concentration of manganese in the blood." ; dc:date "2018-11-04T11:14:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypomanganesemia" ; rdfs:subClassOf obo:HP_0032096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0055071 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032099 obo:IAO_0000115 "The presence of radial grooves in the skin surrounding the mouth (see Figure 4 of PMID:27833976)." ; dc:date "2018-11-04T11:17:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perioral radial furrowing" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0032100 obo:IAO_0000115 "The doll's eye reflex (also known as oculocephalic reflex) is a test of brain function that is performed in comatose patients by elevating the head roughly 30 degrees and rapidly rotating the head from side to side with the eyes kept open. A normal response is for the eyes to move in the opposite direction. If the eyes do not move in the opposite direction this may indicate severe brain damage." ; dc:date "2018-11-04T11:33:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal doll's eye reflex" ; rdfs:subClassOf obo:HP_0007670 . obo:HP_0032101 obo:IAO_0000115 "A type of infection that is regarded as a sign of a pathological susceptibility to infection. There are five general subtypes. (i) Opportunistic infection, meaning infection by a pathogen that is not normally able to cause infection in a healthy host (e.g., pneumonia by Pneumocystis jirovecii or CMV); (ii) Unusual location (focus) of an infection (e.g., an aspergillus brain abscess); (iii) a protracted course or lack of adequate response to treatment (e.g., chronic rhinosinusitis); (iv) Unusual severity or intensity of an infection; and (v) unusual recurrence of infections." ; dc:date "2018-11-04T22:23:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual infection" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0032102 obo:IAO_0000115 "Wilson sign is defined as the elicitation of pain by internally rotating the patient's tibia during knee extension between 90 degrees and 30 degrees of flexion and then relieving that pain by externally rotating the tibia." ; dc:date "2018-11-04T22:45:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Wilson sign may be indicative of medial femoral osteochondritis dissecans. Wilson postulated that impingement of the tibial eminence on the osteochondritic lesion caused pain and a resultant compensatory lateral rotation during gait." ; rdfs:label "Wilson sign" ; rdfs:subClassOf obo:HP_0030839 . obo:HP_0032104 obo:IAO_0000115 "An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by an immediate corrective saccade." ; dc:date "2018-11-04T23:03:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Saccadic oscillations" ; a owl:Class ; rdfs:label "Saccadic oscillation" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0032105 obo:IAO_0000115 "A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern." ; dc:date "2018-11-04T23:04:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032117" ; oboInOwl:hasExactSynonym "Macrosaccadic oscillation" ; a owl:Class ; rdfs:comment "Macrosaccadic oscillation is usually observed in acute damage to the dorsal cerebellum involving the deep cerebellar nuclei, as in demyelination, tumor or haematoma." ; rdfs:label "Macrosaccadic oscillations" ; rdfs:subClassOf obo:HP_0032104 . obo:HP_0032106 obo:IAO_0000115 "Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease." ; dc:date "2018-11-17T13:40:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Scleral icterus", "Yellow conjunctiva", "Yellow sclera", "Yellowing of the whites of the eyes" ; a owl:Class ; rdfs:label "Conjunctival icterus" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0032107 obo:IAO_0000115 "A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus." ; dc:date "2018-11-17T14:09:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The corneal epithelium covers the corneal surface and plays a major role in protection and transparency. Epithelial cells are shed regularly and replaced by stem cell sources located at the limbus, a rim of tissue located at the junction of the cornea and sclera. The limbal epithelial stem cells reside in specific regions at the limbus known as the limbal stem cell niches. Damage to the stem cells or disruption of the niches may lead to Limbal Stem Cell Deficiency. In the absence of a healthy corneal epithelium, the conjunctiva proliferates over the cornea resulting in opacification and vascularization, which in turn may lead to reduced vision, pain, and photophobia." ; rdfs:label "Limbal stem cell deficiency" ; rdfs:subClassOf obo:HP_0004328 . obo:HP_0032108 obo:IAO_0000115 "A mild reduction in the ability to perceive visual contrast characterized by 0.20-0.59 log unit contrast sensitivity loss." ; dc:date "2018-11-17T14:16:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mild reduction in contrast sensitivity" ; a owl:Class ; rdfs:label "Mildly reduced contrast sensitivity" ; rdfs:subClassOf obo:HP_0032036 . obo:HP_0032109 obo:IAO_0000115 "A moderate reduction in the ability to perceive visual contrast characterized by 0.60-0.99 log unit contrast sensitivity loss." ; dc:date "2018-11-17T14:18:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Moderate reduction in contrast sensitivity" ; a owl:Class ; rdfs:label "Moderately reduced contrast sensitivity" ; rdfs:subClassOf obo:HP_0032036 . obo:HP_0032110 obo:IAO_0000115 "A severe reduction in the ability to perceive visual contrast characterized by 1.00 log unit or more contrast sensitivity loss." ; dc:date "2018-11-17T14:20:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severely reduced contrast sensitivity" ; rdfs:subClassOf obo:HP_0032036 . obo:HP_0032111 obo:IAO_0000115 "An abnormality in perception of contrast as measured by the Vistech wall chart sine wave grating test." ; dc:date "2018-11-17T14:23:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal Vistech contrast sensitivity test" ; rdfs:subClassOf obo:HP_0032036 . obo:HP_0032112 obo:IAO_0000115 "An abnormality in perception of contrast as measured by the Pelli-Robson contrast sensitivity chart, which is a large wall-mounted chart, with letters of a fixed size (comprising spatial frequencies appropriate for estimating peak contrast sensitivity) that decrease in contrast." ; dc:date "2018-11-17T14:25:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal Pelli Robson contrast sensitivity chart test" ; rdfs:subClassOf obo:HP_0032036 . obo:HP_0032113 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected." ; dc:date "2018-11-17T14:33:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Semidominant mode of inheritance" ; a owl:Class ; rdfs:comment "Familial hypercholesterolemia is an example of a disease with this inheritance pattern." ; rdfs:label "Semidominant inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0032114 obo:IAO_0000115 "An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by a delayed corrective saccade." ; dc:date "2018-11-17T14:42:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Saccadic intrusion" ; rdfs:subClassOf obo:HP_0000570 . obo:HP_0032116 obo:IAO_0000115 "Horizontal 10-40 degree excursions from fixation and back again." ; dc:date "2018-11-17T14:46:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Macrosquare-wave jerks" ; rdfs:subClassOf obo:HP_0032114 . obo:HP_0032117 obo:IAO_0100001 "HP:0032105" ; a owl:Class ; rdfs:label "obsolete Macrosaccadic oscillation" ; owl:deprecated true . obo:HP_0032118 obo:IAO_0000115 "Inflammation of the retina of the eye." ; dc:date "2018-11-17T14:59:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Note that the term Chorioretinitis suggests that the origin of the process is predominantly in the choroid while Retinitis suggests that the process is mainly in the retina." ; rdfs:label "Retinitis" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0032119 obo:IAO_0100001 "HP:0012109" ; dc:date "2018-11-17T15:31:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Narrow angle glaucoma" ; owl:deprecated true . obo:HP_0032120 obo:IAO_0000115 "Any functional abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord." ; dc:date "2018-11-17T16:57:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal peripheral nervous system physiology" ; rdfs:subClassOf obo:HP_0410008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032121 obo:IAO_0000115 "An abnormal result of a physical examination of the the hand that tests for palsy of the ulnar nerve. This nerve innervates the adductor pollicis and interossei muscles and thereby enables adduction of the thumb and extension of the interphalangeal joint. An abnormal result consists in reduced functionality and muscular weakness in the pinch grip between the thumb and index finger of the affected hand as the patient attempts to pinch a piece of paper that the examiner tries to pull away. The flexor pollicis longus muscle tries to compensate for the weakness by flexing the tip of the thumb at the interphalangeal joint." ; dc:date "2018-11-17T16:58:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Froment thumb sign" ; a owl:Class ; rdfs:label "Froment sign" ; rdfs:subClassOf obo:HP_0032120 . obo:HP_0032122 obo:IAO_0000115 "A reduction in visual acuity with best corrected visual acuity between 1.40 (20/500) and 1.89 logMAR (up to roughly 20/1590)." ; dc:date "2018-11-18T14:04:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Very low visual acuity" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0032123 obo:IAO_0000115 "Best corrected visual acuity worse than 1.90 logMAR (roughly 20/1590)." ; dc:date "2018-11-18T14:06:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ultra-low vision" ; rdfs:subClassOf obo:HP_0007663 . obo:HP_0032124 obo:IAO_0000115 "A deviation of the normal proportion of unswitched memory B cells in circulation relative to the total number of B cells." ; dc:date "2018-11-22T12:51:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of non-class-switched memory B cells" ; a owl:Class ; rdfs:label "Abnormal proportion of unswitched memory B cells" ; rdfs:subClassOf obo:HP_0030373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032125 obo:IAO_0000115 "An increase above the normal proportion of non-class-switched memory B cells relative to the total number of B cells." ; dc:date "2018-11-22T12:52:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of unswitched memory B cells", "Increased proportion of non-class-switched memory B cells" ; a owl:Class ; rdfs:label "Increased proportion of unswitched memory B cells" ; rdfs:subClassOf obo:HP_0032124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000000 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032126 obo:IAO_0000115 "A reduction below the normal proportion of non-class-switched memory B cells relative to the total number of B cells." ; dc:date "2018-11-22T12:53:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of non-class-switched memory B cells", "Reduced proportion of unswitched memory B cells" ; a owl:Class ; rdfs:label "Decreased proportion of unswitched memory B cells" ; rdfs:subClassOf obo:HP_0030374, obo:HP_0032124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000970 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032127 obo:IAO_0000115 "A deviation from the normal proportion of plasmablasts in circulation relative to total number of B cells. Plasmablasts are antibody-secreting cells that originate after infection or vaccination." ; dc:date "2018-11-22T12:59:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Differentiation of B cells into plasmablasts (PB) is most commonly monitored with surface markers CD19, CD20, CD27, CD38, and CD138 and intracellular marker Ki-67." ; rdfs:label "Abnormal plasmablast proportion" ; rdfs:subClassOf obo:HP_0025539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032128 obo:IAO_0000115 "An elevation above the normal proportion of plasmablasts in circulation relative to total number of B cells." ; dc:date "2018-11-22T13:02:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of plasmablasts" ; rdfs:subClassOf obo:HP_0032127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032129 obo:IAO_0000115 "A reduction below the normal proportion of plasmablasts in circulation relative to total number of B cells." ; dc:date "2018-11-22T13:02:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased proportion of plasmablasts" ; rdfs:subClassOf obo:HP_0032127 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032130 obo:IAO_0000115 "Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections." ; dc:date "2018-11-22T13:30:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mycobacterium abscessus abscessus infection" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032131 obo:IAO_0000115 "Cervical dysplasia is the precursor to cervical cancer. It is caused by the persistent infection of the human papillomavirus (HPV) into the cervical tissue. Affected cells develop morphologic features with immature basaloid- type squamous cells and mitotic figures in the upper half of the cervical epithelium." ; dc:date "2018-11-22T13:45:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Uterine cervix dysplasia" ; a owl:Class ; rdfs:label "Cervical dysplasia" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0032132 obo:IAO_0000115 "A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood." ; dc:date "2018-11-22T14:04:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Reductions in total IgG levels in adolescents or adults may be classified as mild-moderate (300-600 mg/dL), significant (100-299 mg/dL), or profoundly reduced (less than 100 mg/dL). In adolescents and adults, a total immunoglobulin (IgG + IgM + IgA) level greater than 600 mg/dL, with confirmed normal antibody responses, probably excludes humoral deficiency. Total immunoglobulin levels of 400 to 600 mg/dL or IgG levels of 200 to 400 mg/dL may contain adequate amounts of antibody; this becomes less likely if total immunoglobulin levels are less than 400 mg/dL or serum IgG levels are less than 200 mg/dL." ; rdfs:label "Decreased circulating total IgG" ; rdfs:subClassOf obo:HP_0004315 . obo:HP_0032133 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin G (IgG) in the blood." ; dc:date "2018-11-22T14:08:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transient decreased circulating total IgG" ; rdfs:subClassOf obo:HP_0032132 . obo:HP_0032134 obo:IAO_0000115 "A lasting reduction beneath the normal level of total immunoglobulin G (IgG) in the blood." ; dc:date "2018-11-22T14:09:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased total IgG in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating total IgG" ; rdfs:subClassOf obo:HP_0032132 . obo:HP_0032135 obo:IAO_0000115 "A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood." ; dc:date "2018-11-22T14:26:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased IgG subclass level in blood" ; a owl:Class ; rdfs:comment "IgG subclass deficiency is defined as a reduction in 1 or more subclasses of IgG (IgG1 and IgG2 in particular) by more than 2 SDs below the mean for age-matched controls. Deficiencies in IgG1 or IgG2 are more likely to cause low serum IgG levels because these are the major components. IgG1 levels stabilize by the age of 5 years; however, adult levels of IgG2, IgG3, and IgG4 may not be achieved until adolescence. Thus, the interpretation of subclass levels is additionally problematic because levels of each subclass increase at different rates during development." ; rdfs:label "Decreased circulating IgG subclass level" ; rdfs:subClassOf obo:HP_0004315 . obo:HP_0032136 obo:IAO_0000115 "A reduction in immunoglobulin levels of the IgG1 subclass in the blood circulation." ; dc:date "2018-11-22T14:29:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased IgG1 level in blood" ; a owl:Class ; rdfs:label "Decreased circulating IgG1 level" ; rdfs:subClassOf obo:HP_0032135 . obo:HP_0032137 obo:IAO_0000115 "A reduction in immunoglobulin levels of the IgG3 subclass in the blood circulation." ; dc:date "2018-11-22T14:29:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased IgG3 level in blood" ; a owl:Class ; rdfs:label "Decreased circulating IgG3 level" ; rdfs:subClassOf obo:HP_0032135 . obo:HP_0032138 obo:IAO_0000115 "A reduction in immunoglobulin levels of the IgG4 subclass in the blood circulation." ; dc:date "2018-11-22T14:29:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased IgG4 level in blood" ; a owl:Class ; rdfs:label "Decreased circulating IgG4 level" ; rdfs:subClassOf obo:HP_0032135 . obo:HP_0032139 obo:IAO_0000115 "Level of isohemagglutinin reduced below expected concentration. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." ; dc:date "2018-11-22T15:04:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased natural antibody to blood group agents", "Partial absence of isohemagglutinins" ; a owl:Class ; rdfs:comment "The determination of isohemagglutinins can be used to evaluate an individual's ability to mount an immune response except in persons with blood group AB." ; rdfs:label "Reduced isohemagglutinin level" ; rdfs:subClassOf obo:HP_0410292 . obo:HP_0032140 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against toxoids and polysaccharides in vaccines, as measured by antibody titer determination following vaccination." ; dc:date "2018-11-22T15:08:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased specific antibody response to vaccination" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0032141 obo:IAO_0000115 "A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck." ; dc:date "2018-11-22T15:23:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Precordial pain" ; rdfs:subClassOf obo:HP_0100749 . obo:HP_0032142 obo:IAO_0000115 "Fetor hepaticus is the characteristic breath of patients with severe parenchymal liver disease, which has been said to resemble the odor of a mixture of rotten eggs and garlic." ; dc:date "2018-11-22T15:28:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Foetor hepaticus" ; a owl:Class ; rdfs:label "Fetor hepaticus" ; rdfs:subClassOf obo:HP_0100812 . obo:HP_0032143 obo:IAO_0000115 "An intense sensation of burning, scalding, or tingling feeling of the tongue or other regions of the oral mucosa." ; dc:date "2018-11-22T15:36:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term implies that there is no obvious oral mucosal lesion causing the pain." ; rdfs:label "Burning mouth" ; rdfs:subClassOf obo:HP_0031815 . obo:HP_0032144 obo:IAO_0000115 "Vomit that has the appearance of coffee grounds, which occurs due to the presence of coagulated blood in the vomit." ; dc:date "2018-11-22T15:39:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coffee grounds emesis", "Coffee grounds vomiting" ; a owl:Class ; rdfs:label "Coffee ground vomitus" ; rdfs:subClassOf obo:HP_0002239 . obo:HP_0032145 obo:IAO_0000115 "Wasting of the sural nerve, a sensory nerve in the calf region of the leg." ; dc:date "2018-11-22T16:26:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atrophy of sural nerve" ; a owl:Class ; rdfs:label "Sural nerve atrophy" ; rdfs:subClassOf obo:HP_0045010 . obo:HP_0032146 obo:IAO_0000115 "Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis." ; dc:date "2018-11-22T16:41:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Haemoglobin C", "HbC haemoglobin", "Hemoglobin C" ; a owl:Class ; rdfs:label "HbC hemoglobin" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0032147 obo:IAO_0000115 "Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet." ; dc:date "2018-12-02T12:02:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Warmth, ambulation, physical exercise, sitting, leg dependence and wearing shoes or gloves can provoke and aggravate symptoms while immersion in ice/cold water, uncovering affected areas, ventilation and elevation can ameliorate these symptoms. Pain attacks usually start with an itchy-like feeling and then progress to a severe burning sensation as was reported by most patients, with the durations of which ranging from several minutes to hours and even days. Erythromelalgia can be a Mendelian trait or can be triggered by polycythemia vera, lymphoproliferative disorders, hypertension, and hyperviscosity." ; rdfs:label "Erythromelalgia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0032148 obo:IAO_0000115 "Intermittent pain, i.e., pain that occurs occasionally and at irregular intervals." ; dc:date "2018-12-02T12:21:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Episodic pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0032149 obo:IAO_0000115 "A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain." ; dc:date "2018-12-02T12:26:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Breakthrough pain" ; rdfs:subClassOf obo:HP_0032148 . obo:HP_0032150 obo:IAO_0000115 "Excruciating burning pain in the rectal area that may be triggered by defecation." ; dc:date "2018-12-02T12:29:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paroxysmal rectal pain" ; rdfs:subClassOf obo:HP_0032148, obo:HP_0500005 . obo:HP_0032151 obo:IAO_0000115 "Recurrent episodes of marked eosinophilia that resolve spontaneously." ; dc:date "2018-12-02T12:56:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Episodic eosinophilia" ; rdfs:subClassOf obo:HP_0001880 . obo:HP_0032152 obo:IAO_0000115 "An anomaly of the hair follicles of the skin that typically presents as small, rough, brown folliculocentric papules distributed over characteristic areas of the skin, particularly the outer-upper arms and thighs." ; dc:date "2018-12-02T13:20:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0040180" ; oboInOwl:hasExactSynonym "Carpet tack sign", "Chicken skin", "Follicular keratosis", "Follicular keratotic plug", "Follicular plugging", "Hyperkeratosis pilaris", "Lichen pilaris" ; a owl:Class ; rdfs:comment "Keratosis pilaris is characterized by abnormal keratinisation of the lining of the follicular infundibulum (the upper portion of the hair follicle). Keratin (i.e., scale) fills the follicle instead of exfoliating. Clinically, the keratotic plugs have been referred to as the carpet tack sign since they project up similar to carpet tacks." ; rdfs:label "Keratosis pilaris" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0032153 obo:IAO_0000115 "A partial dislocation of a joint." ; dc:date "2018-12-02T13:55:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Joint subluxation" ; rdfs:subClassOf obo:HP_0001367 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002157 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032154 obo:IAO_0000115 "Oral aphthous ulcers typically present as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border." ; dc:date "2018-12-02T14:06:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Canker sore" ; a owl:Class ; rdfs:label "Aphthous ulcer" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0032155 obo:IAO_0000115 "A type of abdominal pain characterized by a feeling of contractions and typically fluctuating in intensity." ; dc:date "2018-12-02T14:21:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abdominal cramps" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0032156 obo:IAO_0000115 "Loss of sections of skin either spontaneously or after gentle handling." ; dc:date "2018-12-02T15:19:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Detached skin", "Epidermal detachment", "Skin sloughing" ; a owl:Class ; rdfs:label "Skin detachment" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0032157 obo:IAO_0000115 "Recurrent episodes of genital herpes, typically characterized by stages of erythema, papules, short-lived vesicles, painful ulcers, and crusts on the skin of the genitals and surrounding area, and that typically resolve over a period of 2 to 3 weeks." ; dc:date "2018-12-02T15:33:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent genital herpes" ; rdfs:subClassOf obo:HP_0005353 . obo:HP_0032158 obo:IAO_0000115 "An unusual infection classified by the affected body part." ; dc:date "2018-12-09T12:17:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual infection by anatomical site" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0032159 obo:IAO_0000115 "An infection of the meninges caused by a fungus. Generally, only individuals with deficiencies of the immune system contract fungal meningitis." ; dc:date "2018-12-09T12:21:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fungal meningitis" ; rdfs:subClassOf obo:HP_0001287 . obo:HP_0032160 obo:IAO_0000115 "A type of fungal meningitis caused by an encapsulated yeast that belongs to the genus Cryptococcus. Cryptococcus neoformans and Cryptococcus gattii are responsible for the majority of cases of human cryptococcosis." ; dc:date "2018-12-09T12:26:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cryptococcus yeasts are ubiquitous in the environment and are acquired by inhalation. In the immunocompromised host, reactivation of latent disease is believed to be responsible for the subsequent development of cryptococcal disease. For instance, in persons with depletion of CD4+ T cells, the ability of the immune response to adequately contain cryptococcal infection is impaired." ; rdfs:label "Cryptococcal meningitis" ; rdfs:subClassOf obo:HP_0032159 . obo:HP_0032161 obo:IAO_0000115 "A type of fungal meningitis caused by dissemination of coccidioides to basilar meninges." ; dc:date "2018-12-09T12:30:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Coccidioides species are soil-dwelling fungi that are the causative pathogen of coccidioidomycosis, also known as Valley fever. Infection occurs from inhalation of fungal spores that become airborne from soil in endemic regions. Sixty percent of infections are asymptomatic. The rate of dissemination from primary infection to extrapulomonary sites is higher in immune-compromised individuals. A common site of dissemination is to the basilar meninges, resulting in coccidioidal meningitis." ; rdfs:label "Coccidioidal meningitis" ; rdfs:subClassOf obo:HP_0032159 . obo:HP_0032162 obo:IAO_0000115 "A type of infection of the skin that can be regarded as a sign of a pathological susceptibility to infection." ; dc:date "2018-12-09T12:47:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual skin infection" ; rdfs:subClassOf obo:HP_0011122, obo:HP_0032158 . obo:HP_0032163 obo:IAO_0000115 "Molluscum contagiosum is a cutaneous viral infection that is commonly observed in both healthy and immunocompromised children. The infection is caused by a member of the Poxviridae family, the molluscum contagiosum virus. Molluscum contagiosum presents as single or multiple small white or flesh-colored papules that typically have a central umbilication. The central umbilication may be difficult to observe in young children and, instead, may bear an appearance similar to an acneiform eruption. The lesions vary in size (from 1 mm to 1 cm in diameter) and are painless, although a subset of patients report pruritus in the area of infection. On average, 11-20 papules appear on the body during the course of infection and generally remains a self-limiting disease. However, in immunosuppressed patients, molluscum contagiosum can be a severe infection with hundreds of lesions developing on the body. Extensive eruption is indicative of an advanced immunodeficiency state." ; dc:date "2018-12-09T12:51:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Molluscum contagiosum" ; rdfs:subClassOf obo:HP_0032162 . obo:HP_0032164 obo:IAO_0000115 "An elevated circulating concentration of folic acid, which is also known as vitamin B9." ; dc:date "2018-12-09T14:04:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased blood folate concentration" ; rdfs:subClassOf obo:HP_0040087 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032165 obo:IAO_0000115 "Placental mesenchymal dysplasia is a rare anomaly characterized by placentomegaly, dilatation of chorionic vessels and hydropic stem villi with cistern-like formation. It is often clinically mistaken for a partial hydatidiform mole but there is no trophoblastic proliferation. P57 immunohistochemical expression is discordant, showing a normal positive expression in the cytotrophoblastic cells, and loss of expression in the stromal cells." ; dc:date "2018-12-09T14:14:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Placental mesenchymal dysplasia is an unusual abnormality of the stem villi of the placenta that may be mistaken for a hydatidiform mole, and in particular, partial mole, owing to the mixture of cysts and normal-appearing parenchyma." ; rdfs:label "Placental mesenchymal dysplasia" ; rdfs:subClassOf obo:HP_0100767 . obo:HP_0032166 dc:date "2018-12-09T14:21:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Unusual GI infection" ; a owl:Class ; rdfs:label "Unusual gastrointestinal infection" ; rdfs:subClassOf obo:HP_0012719 . obo:HP_0032167 obo:IAO_0000115 "An infection of the small intestine (enteritis) by clostridium difficile." ; dc:date "2018-12-09T14:22:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "C. difficile enteritis" ; a owl:Class ; rdfs:comment "Clostridium difficile (C. difficile) is a common nosocomial infection caused by a gram-negative spore forming organism that most commonly leads to pseudomembranous colitis. Certain individuals are able to mount an effective immunoglobulin G response against C. difficile toxin A. This humoral immune response against the C. difficile toxin is believed to allow an individual to become an asymptomatic carrier. In contrast, people who fail to mount an immune response to C. difficile toxin are susceptible to infection. In general, patients on immunosuppressive therapy have a blunted ability to mount immune responses and, therefore, may be at greater risk for infection." ; rdfs:label "Clostridium difficile enteritis" ; rdfs:subClassOf obo:HP_0032166 . obo:HP_0032168 obo:IAO_0000115 "An infection of the colon (colitis) by clostridium difficile." ; dc:date "2018-12-09T14:28:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Clostridium difficile colitis" ; rdfs:subClassOf obo:HP_0032166 . obo:HP_0032169 obo:IAO_0000115 "A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection." ; dc:date "2018-12-16T15:11:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Unusual course of infection" ; a owl:Class ; rdfs:label "Severe infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0032170 obo:IAO_0000115 "An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterised by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestions including VZV pneumonia, hepatitis, meningitis, and disseminated varicella." ; dc:date "2018-12-16T15:12:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Varicella-zoster virus (VZV) is one of eight herpes viruses known to cause human infection and is distributed worldwide. Varicella zoster infections are considered to be mild and ubiquitous infections predominantly affecting the paediatric population. However, in adults and in specific groups of patients, such as those who are immunosuppressed, varicella infections can be fulminant and life threatening." ; rdfs:label "Severe varicella zoster infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0032171 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the urinary bladder. Bladder pain may be more pronounced with a full bladder and relieved upon urination, but this is not always the case." ; dc:date "2018-12-16T15:23:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bladder pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0032172 obo:IAO_0000115 "A crescent of air surrounding a soft-tissue mass in a pulmonary cavity and can be seen in both plain X-ray and CT scan." ; dc:date "2019-01-06T10:55:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The air crescent sign is said to be characteristic of invasive pulmonary aspergillosis, but it can also be seen in cavitating neoplasms, lung abscesses, and infections. This sign is considered a good marker of immune activity as it is seen when the necrotic tissue gets invaded by leukocytes and replaced by air in invasive pulmonary aspergillosis. Other conditions in which air crescent sign can be seen are pulmonary gangrene, pulmonary hematoma, Rasmussen aneurysm in a tuberculous cavity, and lung hydatid." ; rdfs:label "Air crescent sign" ; rdfs:subClassOf obo:HP_0033775 . obo:HP_0032173 obo:IAO_0000115 "This sign is seen in pneumomediastinum in which air accumulates between the lower border of the heart and the superior part of the diaphragm, which results in complete visualization of the diaphragm in chest X-ray, hence named continuous diaphragm sign." ; dc:date "2019-01-06T10:59:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Normally, the central part of the diaphragm is obscured by the heart, and hence is not seen on chest radiographs. Though this sign is commonly seen in pneumomediastinum, it can occasionally be also seen in pneumopericardium. This sign when seen, is a differential tool between pneumomediastinum and pneumothorax." ; rdfs:label "Continuous diaphragm sign" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0032174 obo:IAO_0000115 "The tree-in-bud pattern represents centrilobular branching structures that resemble a budding tree. The pattern reflects a spectrum of endo- and peribronchiolar disorders, including mucoid impaction, inflammation, and/or fibrosis (See Figure 70 of PMID:18195376)." ; dc:date "2019-01-06T11:14:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This pattern is most pronounced in the lung periphery and is usually associated with abnormalities of the larger airways. It is particularly common in diffuse panbronchiolitis, endobronchial spread of mycobacterial infection, and cystic fibrosis. A similar pattern is a rare manifestation of arteriolar (microangiopathic) disease." ; rdfs:label "Tree-in-bud pattern" ; rdfs:subClassOf obo:HP_0033775 . obo:HP_0032175 obo:IAO_0000115 "This finding is composed of a ring-shaped opacity representing a dilated bronchus in cross section and a smaller adjacent opacity representing its pulmonary artery, with the combination resembling a signet (or pearl) ring. It is the basic sign of bronchiectasis in pulmonary computed tomography imaging." ; dc:date "2019-01-06T11:17:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Fig 66 of PMID:18195376." ; rdfs:label "Signet ring sign" ; rdfs:subClassOf obo:HP_0033775 . obo:HP_0032176 obo:IAO_0000115 "An apical cap is a caplike lesion at the lung apex, usually caused by intrapulmonary and pleural fibrosis pulling down extrapleural fat or possibly by chronic ischemia resulting in hyaline plaque formation on the visceral pleura. The prevalence increases with age. It can also be seen in hematoma resulting from aortic rupture or in other fluid collection associated with infection or tumor, either outside the parietal pleura or loculated within the pleural space." ; dc:date "2019-01-06T11:20:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Apical cap", "Apical pleural thickening" ; a owl:Class ; rdfs:comment "The usual appearance is of homogeneous soft-tissue attenuation capping the extreme lung apex (uni- or bilaterally), with a sharp or irregular lower border (See Figure 6 of PMID:18195376). Thickness is variable, ranging up to about 30 mm. An apical cap occasionally mimics apical consolidation on transverse CT scans." ; rdfs:label "Apical pulmonary opacity" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0032177 obo:IAO_0000115 "Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia)." ; dc:date "2019-01-06T11:25:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In radiographs and CT scans, consolidation appears as a homogeneous increase in pulmonary parenchymal attenuation that obscures the margins of vessels and airway walls (See Figure 19 of PMID:18195376). An air bronchogram may be present. The attenuation characteristics of consolidated lung are only rarely helpful in differential diagnosis (eg, decreased attenuation in lipoid pneumonia and increased in amiodarone toxicity)." ; rdfs:label "Parenchymal consolidation" ; rdfs:subClassOf obo:HP_0031457 . obo:HP_0032178 obo:IAO_0000115 "A dermatosis characterized by generalized shiny, enamel-like, hyperpigmented scales in an irregular pattern. The scales may peel or desquamate, rather like old, sun-baked blistered paint, often with areas of underlying hypopigmentation. This has led to the terms peeling paint or flaky paint dermatosis (See the Figure in PMID:24285001)." ; dc:date "2019-01-06T13:46:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flaky paint skin appearance" ; a owl:Class ; rdfs:comment "Flaky paint dermatosis is a cutaneous manifestations of kwashiorkor." ; rdfs:label "Flaky paint dermatosis" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0032179 obo:IAO_0000115 "An abnormal concentration of globulins in the blood. Albumin makes up more than half of the total protein present in serum. The remaining blood proteins except albumin and fibrinogen (which is not in serum) are referred to as globulins. The globulin fraction includes hundreds of serum proteins including carrier proteins, enzymes, complement, and immunoglobulins. Most of these are synthesized in the liver, although the immunoglobulins are synthesized by plasma cells. Globulins are divided into four groups by electrophoresis. The four fractions are alpha1, alpha2, beta and gamma, depending on their migratory pattern between the anode and the cathode." ; dc:date "2019-01-06T14:01:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating globulin level" ; a owl:Class ; rdfs:comment "Any increase or decrease in the globulin fraction should be evaluated by serum electrophoresis. The alpha1 fraction consists mainly of alpha1 antitrypsin, which is an acute phase reactant that goes up in acute inflammation. The alpha1 fraction is reduced in congenital alpha1 antitrypsin deficiency. The alpha2 region consists mainly of alpha2 macroglobulin and haptoglobin. The major beta globulin is transferring. Elevations can occur in severe iron deficiency." ; rdfs:label "Abnormal circulating globulin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032180 obo:IAO_0000115 "An abnormal level of an analyte measured in the blood." ; dc:date "2019-01-12T13:45:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating metabolite concentration" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0032181 obo:IAO_0000115 "An abnormality of the hepatic veins, which normally drain de-oxygenated blood from the liver into the inferior vena cava, whereby the hepatic veins drain into the left atrium." ; dc:date "2019-01-12T14:05:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anomalous hepatic venous drainage into the left atrium" ; rdfs:subClassOf obo:HP_0006707 . obo:HP_0032182 obo:IAO_0000115 "An abnormal proportion of memory T cells compared to the total number of T cells in the blood. Memory T cells have previously encountered and responded to their cognate antigen and upon a repeated encounter with the antigen can mount a faster and stronger response." ; dc:date "2019-01-12T14:32:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of CD4+CD29+ cells" ; a owl:Class ; rdfs:label "Abnormal proportion of memory T cells" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032183 obo:IAO_0000115 "An abnormally reduced proportion of memory T cells compared to the total number of T cells in the blood." ; dc:date "2019-01-12T14:35:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+CD29+ cells" ; a owl:Class ; rdfs:label "Decreased proportion of memory T cells" ; rdfs:subClassOf obo:HP_0032182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032184 obo:IAO_0000115 "An abnormally elevated proportion of memory T cells compared to the total number of T cells in the blood." ; dc:date "2019-01-12T14:37:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased proportion of CD4+CD29+ cells" ; a owl:Class ; rdfs:label "Increased proportion of memory T cells" ; rdfs:subClassOf obo:HP_0032182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032185 obo:IAO_0000115 "The presense of molluscum contagiosum lesions across multiple areas of the body." ; dc:date "2019-01-12T14:58:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Molluscum contagiosum (MC) are very common cutaneous warts caused by molluscum contagiosum virus (MCV), a double-stranded DNA virus of the poxvirus family. The typical clinical presentation consists of small, umbilicated, skin-coloured, pearly papules with predilection of the trunk, axillae, antecubital and popliteal fossae and genital area. Incidence first peaks in pre-school children. In immunocompetent individuals, lesions usually clear spontaneously within several months or years." ; rdfs:label "Disseminated molluscum contagiosum" ; rdfs:subClassOf obo:HP_0032163 . obo:HP_0032186 obo:IAO_0000115 "A benign or malignant neoplasm that affects the anal canal or anal margin." ; dc:date "2019-01-15T10:13:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anal neoplasm" ; rdfs:subClassOf obo:HP_0004378, obo:HP_0007378 . obo:HP_0032187 obo:IAO_0000115 "Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer." ; dc:date "2019-01-15T10:14:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (HPV) infection. Anal cancer is defined as cancer arising from the squamous epithelium of the anus, making it distinct from colorectal cancer. The anal canal consists of stratified squamous epithelium originating outside the body and extending into the anus up to the dentate line, the point where it intersects the columnar epithelium of the rectum. Thus, the vast majority of anal cancer is squamous cell carcinoma (SCC), with a small minority consisting of adenocarcinoma or skin cancer variants. Anal cancer is preceded by intraepithelial neoplasia, a premalignant lesion." ; rdfs:label "Anal intraepithelial neoplasia" ; rdfs:subClassOf obo:HP_0032186 . obo:HP_0032188 obo:IAO_0000115 "An increased cellular sensitivity to the DNA cross-linking agent, mitomycin C (MMC). In the presence of increased sensitivity, MMC causes increased cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle." ; dc:date "2019-01-15T11:19:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cellular hypersensitivity to mitomycin C is used in diagnostic criteria for Fanconi Anemia." ; rdfs:label "Cellular hypersensitivity to mitomycin C" ; rdfs:subClassOf obo:HP_0003254 . obo:HP_0032189 obo:IAO_0000115 "An increased cellular sensitivity to the DNA cross-linking agent, diepoxybutane (DEB). In the presence of increased sensitivity, DEB causes cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle." ; dc:date "2019-01-15T11:20:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cellular hypersensitivity to diepoxybutane is used in diagnostic criteria for Fanconi Anemia." ; rdfs:label "Cellular hypersensitivity to diepoxybutane" ; rdfs:subClassOf obo:HP_0003254 . obo:HP_0032190 obo:IAO_0000115 "Abnormal structure of the meniscus of the knee, two crescent shape fibrocartilaginous pads that disperse the weight of the body and reduce friction of the knee joint during movement." ; dc:date "2019-01-15T11:29:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The meniscus is a fibrocartilaginous structure of the knee joint that enables the even distribution of a weight-bearing load across the articular surfaces. The menisci bear between 40 to 70% of the load across the knee, and the rest of the load is transmitted directly to the articular cartilage." ; rdfs:label "Abnormal meniscus morphology" ; rdfs:subClassOf obo:HP_0034669 . obo:HP_0032191 obo:IAO_0000115 "A tear in the cartilaginous pad (meniscus) of the knee." ; dc:date "2019-01-15T11:31:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Not all meniscal injuries require surgery. Some of them have the ability to heal. The meniscal tear pattern and the presence of adequate vascularity are both key points. Tears within 3 mm of the meniscosynovial junction usually have an adequate blood supply that allows healing. Tears of 5 mm or more from this junction are considered avascular and need surgical intervention." ; rdfs:label "Torn meniscus" ; rdfs:subClassOf obo:HP_0032190 . obo:HP_0032192 obo:IAO_0000115 "Hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast." ; dc:date "2019-01-19T12:26:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with the former being followed by an endoreplication of the male pronucleus leading to a complete hydatidiform mole (CHM) 2. A triploid zygote (fertilization by 2 spermatozoa) leading to a partial hydatidiform mole (PHM) but can also lead to haploid and diploid clones. The diploid clone may produce a normal fetus while the haploid clone after endoreplication generates a CHM 3. A nutritional defect during the differentiation of the oocytes or the deterioration of the limited oxygen pressure during the first trimester of gestation may lead to the formation of a HM." ; rdfs:label "Hydatidiform mole" ; rdfs:subClassOf obo:HP_0001194 . obo:HP_0032193 obo:IAO_0000115 "An abnormal decrease in the average size of low-density lipoprotein particle size in the blood circulation." ; dc:date "2019-01-19T12:51:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Elevated levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of developing coronary artery disease. LDL particles are the major cholesterol-carrying lipoproteins in the blood circulation, consisting of a hydrophobic core of cholesterol esters and triglycerides surrounded by phospholipds, free cholesterol, and one molecule of apolipoprotein B-100 on the surface of the molecule. The LDL particle population is heterogeneous with the respect to size, density and composition. Distinct subpopulations vary in isoelectric point, electrical charge, hydrodynamic properties and immunoreactivity." ; rdfs:label "Decreased low-density lipoprotein particle size" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0032195 obo:IAO_0000115 "Any anomaly of the S wave, which is the third component of the QRS wave complex. The S wave signifies the final depolarization of the ventricles at the base of the heart." ; dc:date "2019-01-19T13:30:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal S wave" ; rdfs:subClassOf obo:HP_0012249 . obo:HP_0032196 obo:IAO_0000115 "Increased amplitude (0.1 mV or more) and/or duration (40 ms or more) of the S wave as measured in lead I of the electrocardiogram." ; dc:date "2019-01-19T13:32:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Prominent S wave in lead I" ; rdfs:subClassOf obo:HP_0032195 . obo:HP_0032197 obo:IAO_0000115 "Abnormal depth of the S wave in lead V5 of the electrocardiogram." ; dc:date "2019-01-19T13:39:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The S wave refers to the negative deflection after an R wave within the QRS complex. This term refers to an abnormally deep (negative) deflection of the S wave in lead V5." ; rdfs:label "Deep S wave in lead V5" ; rdfs:subClassOf obo:HP_0032195 . obo:HP_0032198 obo:IAO_0000115 "Abnormally short time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." ; dc:date "2019-01-19T15:32:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased INR", "Decreased PT", "Decreased international normalised ratio", "Decreased international normalized ratio" ; a owl:Class ; rdfs:label "Decreased prothrombin time" ; rdfs:subClassOf obo:HP_0032199 . obo:HP_0032199 obo:IAO_0000115 "Any deviation from the normal amount of time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." ; dc:date "2019-01-19T15:34:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal PT" ; a owl:Class ; rdfs:label "Abnormal prothrombin time" ; rdfs:subClassOf obo:HP_0012200 . obo:HP_0032200 obo:IAO_0000115 "The presence of thick collagen bundles around blood vessels, often in an onion-skin type whorling pattern." ; dc:date "2019-01-20T11:05:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perivascular fibrosis" ; rdfs:subClassOf obo:HP_0033353 . obo:HP_0032201 obo:IAO_0000115 "The term rotator cuff describes the tendons connecting the infraspinatus, supraspinatus, teres minor, and subscapularis muscles to the humeral head.Traumatic tears of the rotator cuff tend to occur at the tendon-bone junction of the supraspinatus and greater tuberosity of the humerus whereas degenerative tears tend to be seen posteriorly at the junction of the supraspinatus and infraspinatu A rotator cuff tear is when one or more of these tendons tears or detaches from the humerus." ; dc:date "2019-01-20T11:23:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Rotator cuff tears can be caused by injury, overuse, or other causes and may be associated with pain and swelling of the shoulder." ; rdfs:label "Rotator cuff tear" ; rdfs:subClassOf obo:HP_0003043, obo:HP_0100261 . obo:HP_0032202 obo:IAO_0000115 "Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognised: the HPV-associated high-grade squamous intraepithelial lesion/usual VIN (HSIL/uVIN) and the non-HPV-associated differentiated VIN (dVIN). HSIL is clinically identified by its multifocal, warty appearance and on histology by conspicuous cytological and architectural atypia. Differentiated VIN, on the other hand, often produces ill-defined lesions, and on histology, notoriously mimics non-neoplastic epithelial disorders (NNED), particularly LS. As a result, dVIN is rarely identified in advance of a diagnosis of invasive malignancy, despite being the precursor lesion of the majority of VSCC." ; dc:date "2019-01-20T13:31:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vulvar intraepithelial neoplasia" ; rdfs:subClassOf obo:HP_0030416 . obo:HP_0032203 obo:IAO_0000115 "Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236)." ; dc:date "2019-01-20T14:41:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lymphonodular hyperplasia of the colon" ; a owl:Class ; rdfs:comment "The presence of LNH in the mucosa of the colon and/or terminal ileum is a frequent finding (30%) in children undergoing colonoscopy. Unless associated with other endoscopic lesions, LNH is mostly related to a condition of delayed-type food hypersensitivity and affects mainly preschool or school-age children with hematochezia." ; rdfs:label "Lymphoid nodular hyperplasia" ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0032204 obo:IAO_0000115 "Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed." ; dc:date "2019-01-20T15:00:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The mechanisms by which an EBV infection becomes chronic active are likely to be heterogenous and may involve host immune factors, viral factors, or both." ; rdfs:label "Chronic active Epstein-Barr virus infection" ; rdfs:subClassOf obo:HP_0031035 . obo:HP_0032205 obo:IAO_0000115 "An increased circulation of galectin-3 in the blood circulation." ; dc:date "2019-01-20T15:21:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Galectin-3 is a member of the family of beta-galactoside-binding endogenous lectins. It is a multifunctional factor that binds to distinct ligands and triggers production of matrix metalloproteinases, and thereby plays a role in cardiac fibrosis and remodelling." ; rdfs:label "Increased circulating galectin-3 level" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032207 obo:IAO_0100001 "HP:0025454" ; dc:date "2019-01-20T15:49:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal cerebrospinal fluid metabolite concentration" ; owl:deprecated true . obo:HP_0032208 obo:IAO_0000115 "An increased concentration of type 1 collagen N-terminal telopeptide (NTx) level in the urine. Generally the test is performed over a period of time, for instance, 10 cc of morning urine can be collected following 12 hours overnight fasting or for 24 hours." ; dc:date "2019-01-20T16:17:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased collagen crosslinked N-telopeptide [Moles/volume] in 24 hour urine", "Increased urine NTx level" ; a owl:Class ; rdfs:comment "Telopeptides are tiny protein particles found particularly in type I collagen that include 15-20 amino acids. Telopeptides bound to the ends of these amino acids are removed from the body through the urine as a result of collagen metabolism. During resorption, amino and carboxyl terminal fragments, called telopeptides, are bound to collagens with cross links and can be released into the circulation and excreted in the urine. Some recent studies have demonstrated that the type 1 collagen N-terminal telopeptide (NTx) level is more specific to bone tissue than any other resorption markers." ; rdfs:label "Increased urinary type 1 collagen N-terminal telopeptide level" ; rdfs:subClassOf obo:HP_0033384 . obo:HP_0032209 obo:IAO_0000115 "A deviation from the normal concentration of free triiodothyronine (T3) in the blood circulation. A proportion of T3 is bound to plasma proteins in the blood, including mainly thyroxine binding globulin, transthyretin, and albumin. T3 that is not bound to a protein is referred to as free T3." ; dc:date "2019-01-20T20:34:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating free T3 level", "Abnormal circulating free triiodotyronine concentration" ; a owl:Class ; rdfs:label "Abnormal circulating free T3 concentration" ; rdfs:subClassOf obo:HP_0031508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18258 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032210 obo:IAO_0000115 "A reduced concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation." ; dc:date "2019-01-20T20:42:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating free triiodothyronine" ; a owl:Class ; rdfs:label "Decreased circulating free T3" ; rdfs:subClassOf obo:HP_0032209 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18258 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032211 obo:IAO_0000115 "An increased number of epithelial cells per high-power field in urinanalysis." ; dc:date "2019-01-20T21:01:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There are three types of epithelial cells that are encountered upon urinalysis, squamous, renal tubular, and transitional." ; rdfs:label "Increased urinary epithelial cell count" ; rdfs:subClassOf obo:HP_0012614 . obo:HP_0032212 obo:IAO_0000115 "An increased number of squamous epithelial cells per high-power field in urinanalysis." ; dc:date "2019-01-20T21:04:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Squamous epithelial cells may indicate contamination of the urine sample and are a poor predictor of urine culture contamination," ; rdfs:label "Increased urinary squamous epithelial cell count" ; rdfs:subClassOf obo:HP_0032211 . obo:HP_0032213 obo:IAO_0000115 "An increased number of renal tubular epithelial cells per high-power field in urinanalysis." ; dc:date "2019-01-20T21:05:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary renal tubular epithelial cell count" ; rdfs:subClassOf obo:HP_0032211 . obo:HP_0032214 obo:IAO_0000115 "An increased number of transitional epithelial cells per high-power field in urinanalysis." ; dc:date "2019-01-20T21:07:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Transitional epithelial cells can be found in urinary tract starting from the renal pelvis down the ureters to the bladder and the proximal urethra." ; rdfs:label "Increased urinary transitional epithelial cell count" ; rdfs:subClassOf obo:HP_0032211 . obo:HP_0032215 obo:IAO_0000115 "Multiple skin warts located in multiple parts of the body, e.g., neck, trunks, and extremities." ; dc:date "2019-01-20T21:19:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated cutaneous warts" ; rdfs:subClassOf obo:HP_0200043 . obo:HP_0032216 obo:IAO_0000115 "Abnormally increased intraepithelial lymphocyte count. This finding may be appreciated as large numbers of surface intraepithelial lymphocytes as seen (for instance) with hematoxylin and eosin staining of a colonic biopsy sample taken during colonoscopy." ; dc:date "2019-01-21T00:37:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lymphocytic infiltration of the colorectal mucosa" ; rdfs:subClassOf obo:HP_0025090 . obo:HP_0032217 obo:IAO_0000115 "A skin nodule that is unusually hard (indurated)." ; dc:date "2019-01-21T00:45:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Indurated nodule" ; rdfs:subClassOf obo:HP_0200036 . obo:HP_0032218 obo:IAO_0000115 "A reduction in the proportion of CD4-positive T cells relative to the total number of T cells." ; dc:date "2019-01-21T00:48:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+ cells", "Decreased proportion of CD4-positive, alpha-beta T cells", "Reduced proportion of CD4-positive cells" ; a owl:Class ; rdfs:label "Decreased proportion of CD4-positive T cells" ; rdfs:subClassOf obo:HP_0031392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032219 obo:IAO_0000115 "An elevation in the proportion of CD4-positive T cells relative to the total number of T cells." ; dc:date "2019-01-21T00:48:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of CD4-positive T cells", "Increased proportion of CD4+ T cells", "Increased proportion of CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Increased proportion of CD4-positive T cells" ; rdfs:subClassOf obo:HP_0031392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000624 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032220 obo:IAO_0000115 "Inflammation of the liver characterized by a mononuclear cell infiltrate whereby portal inflammatory cells extend through the limiting plate between the portal tract and liver parenchyma." ; dc:date "2019-01-21T01:12:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interface hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0032221 obo:IAO_0000115 "The engulfing of lymphocytes by hepatocytes, which typically occurs in the interface hepatitis area." ; dc:date "2019-01-21T01:20:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Emperipolesis is derived from the Greek (em-inside; peri-around; polemai-wander about) and is as the active penetration of one cell by another which remains intact. It differs from phagocytosis in that an engulfed cell exists temporarily within another cell and with an intact normal structure while in phagocytosis, the engulfed cell is destroyed by the protective action of lysosomal enzymes." ; rdfs:label "Periportal emperipolesis" ; rdfs:subClassOf obo:HP_0030146 . obo:HP_0032222 obo:IAO_0000115 "The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification." ; dc:date "2019-01-21T01:40:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Serrated polyposis" ; a owl:Class ; rdfs:label "Serrated intestinal polyps" ; rdfs:subClassOf obo:HP_0200008 . obo:HP_0032223 obo:IAO_0000115 "Any of the various types of human blood whose antigen characteristics determine compatibility in transfusion. While the ABO and Rhesus sytems are the most well known, there are in total about 300 different blood type antigens distributed across 34 different blood type systems." ; dc:date "2019-01-24T11:33:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "At present, there are 34 blood group systems recognized by the International Society for Blood Transfusion." ; rdfs:label "Blood group" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0032224 obo:IAO_0000115 "The ABO system consists of A and B antigens and antibodies against these antigens." ; dc:date "2019-01-24T11:40:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The ABO histo-blood group consists of two antigens (A and B antigens) and four blood types (types A, B, AB, and O). The A and B antigens are the product of the ABO gene and are autosomal codominant. The group O phenotype is an autosomal-recessive phenotype due to the homozygous inheritance of two null ABO alleles. Group O individuals express the H antigen, the biosynthetic precursor to A and B antigens. ABO, therefore, is the blood type, whereas A, B, and H refer to the antigens." ; rdfs:label "ABO blood group" ; rdfs:subClassOf obo:HP_0032223 . obo:HP_0032225 obo:IAO_0000115 "Perifollicular fibroma is a rare cutaneous hamartoma that shows differentiation in the connective tissue sheath of hair follicles. It can occur as a solitary papule or as multiple lesions. Histologically, the lesion consists of a concentric arrangement of cellular fibrous tissue around a normal hair follicle." ; dc:date "2019-01-26T14:14:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Multiple Perifollicular fibroma (PFF) lesions have been linked to adenomatous colonic polyps and they may be inherited as an autosomal dominant trait. Most reports have described multiple PFF lesions involving the scalp." ; rdfs:label "Perifollicular fibroma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0032226 obo:IAO_0000115 "Any structural anomaly of the sebaceous glands." ; dc:date "2019-01-26T14:26:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sebaceous glands are found all over the human body except on the palms of the hands and soles of the feet. The glands are numerous on the face and scalp and are sparse in areas such as the back. They can number as many as 400-900 glands/cm2 on the face. Sebaceous glands are usually found in association with a hair follicle, which, together, is referred to as a pilosebaceous unit. The sebaceous gland is located in association with the upper portion of the hair follicle, where it is not affected by the hair cycle. Sebaceous glands can be unilobular or multilobular. Although a majority of sebaceous glands are part of a pilosebaceous unit, some glands can be found without an associated hair follicle. Sebaceous glands secrete sebum, which contains cholesterol, cholesteryl esters, squalene, fatty acids, diglycerides and triglycerides, and wax esters." ; rdfs:label "Abnormal sebaceous gland morphology" ; rdfs:subClassOf obo:HP_0011138 . obo:HP_0032227 obo:IAO_0000115 "A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elswehere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola." ; dc:date "2019-01-26T14:30:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sebaceous hyperplasia" ; rdfs:subClassOf obo:HP_0032226 . obo:HP_0032228 obo:IAO_0000115 "A small benign fibrovascular tumor of the dermal part of the hair disk. Trichodiscoma is rather simple in appearance and consists of a dome-shaped fibrous tumor with a prominent vascular component that fills the papillary dermis under an atrophic epidermis. As in a normal hair disk, a hair follicle may be present at one edge of the papular lesion." ; dc:date "2019-01-26T14:38:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to trichodiscoma, fibrofolliculoma shows a keratin-plugged and often distorted hair follicle in the center of the lesion. A mantle of mucoid or fibrous stroma surrounds this central follicle; thin epithelial strands emerge from the central follicle and may form a netlike pattern." ; rdfs:label "Trichodiscoma" ; rdfs:subClassOf obo:HP_0012842 . obo:HP_0032229 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against proteins predominantly expressed in perinuclear region of neutrophils." ; dc:date "2019-01-26T14:41:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "p-ANCA positivity" ; a owl:Class ; rdfs:label "Perinuclear antineutrophil antibody positivity" ; rdfs:subClassOf obo:HP_0003453 . obo:HP_0032230 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils." ; dc:date "2019-01-26T14:43:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-neutrophil cytoplasmic antibody positivity" ; a owl:Class ; rdfs:label "Cytoplasmic antineutrophil antibody positivity" ; rdfs:subClassOf obo:HP_0003453 . obo:HP_0032231 obo:IAO_0000115 "A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells." ; dc:date "2019-01-26T14:52:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypochromia" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0032232 obo:IAO_0000115 "An increased concentration of the MB isoform of creatine kinase in the blood circulation." ; dc:date "2019-01-26T17:05:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating CK MB isoform" ; a owl:Class ; rdfs:comment "All CK isoforms are encoded by separate nuclear genes and, in most tissues, a single cytosolic CK isoform is co-expressed together with a single mitochondrial CK isoform (mtCK). Cytosolic muscle-type CK (M-CK) and brain-type CK (B-CK) form homodimers or heterodimers, e.g. MM-CK in skeletal muscle, MM, MB and BB-CK in heart, or BB-CK in brain, kidney, spermatozoa, skin and many other tissues. MtCK is situated in the outer mitochondrial compartment and occurs as sarcomeric mtCK (smtCK) expressed mainly in muscle tissue and as ubiquitous mtCK (umtCK) expressed in a large number of other cells and tissues. CK-MB levels can rise upon myocardial injury, CK-MM rises upon skeletal muscle damage, and CK-BB can rise with brain injury." ; rdfs:label "Increased circulating creatine kinase MB isoform" ; rdfs:subClassOf obo:HP_0040081 . obo:HP_0032233 obo:IAO_0000115 "An increased concentration of the BB isoform of creatine kinase in the blood circulation." ; dc:date "2019-01-26T17:11:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating CK BB isoform" ; a owl:Class ; rdfs:comment "All CK isoforms are encoded by separate nuclear genes and, in most tissues, a single cytosolic CK isoform is co-expressed together with a single mitochondrial CK isoform (mtCK). Cytosolic muscle-type CK (M-CK) and brain-type CK (B-CK) form homodimers or heterodimers, e.g. MM-CK in skeletal muscle, MM, MB and BB-CK in heart, or BB-CK in brain, kidney, spermatozoa, skin and many other tissues. MtCK is situated in the outer mitochondrial compartment and occurs as sarcomeric mtCK (smtCK) expressed mainly in muscle tissue and as ubiquitous mtCK (umtCK) expressed in a large number of other cells and tissues. CK-MB levels can rise upon myocardial injury, CK-MM rises upon skeletal muscle damage, and CK-BB can rise with brain injury." ; rdfs:label "Increased circulating creatine kinase BB isoform" ; rdfs:subClassOf obo:HP_0040081 . obo:HP_0032234 obo:IAO_0000115 "An increased concentration of the MM isoform of creatine kinase in the blood circulation." ; dc:date "2019-01-26T17:12:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating CK MM isoform" ; a owl:Class ; rdfs:comment "All CK isoforms are encoded by separate nuclear genes and, in most tissues, a single cytosolic CK isoform is co-expressed together with a single mitochondrial CK isoform (mtCK). Cytosolic muscle-type CK (M-CK) and brain-type CK (B-CK) form homodimers or heterodimers, e.g. MM-CK in skeletal muscle, MM, MB and BB-CK in heart, or BB-CK in brain, kidney, spermatozoa, skin and many other tissues. MtCK is situated in the outer mitochondrial compartment and occurs as sarcomeric mtCK (smtCK) expressed mainly in muscle tissue and as ubiquitous mtCK (umtCK) expressed in a large number of other cells and tissues. CK-MB levels can rise upon myocardial injury, CK-MM rises upon skeletal muscle damage, and CK-BB can rise with brain injury." ; rdfs:label "Increased circulating creatine kinase MM isoform" ; rdfs:subClassOf obo:HP_0040081 . obo:HP_0032235 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against La/SSB autoantigens." ; dc:date "2019-01-26T17:16:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anti-Ro/SSA and anti-La/SSB are considered hallmarks of Sjogrens syndrome and are associated with systemic disease, but are also present in the sera of systemic lupus erythematodes patients. The most common antinuclear antibodies in Sjogren patients are those directed against the autoantigens Ro/SSA and La/SSB. The Ro/La particle is a protein-RNA complex formed by the association of the Ro60, and La/SSB proteins with small cytoplasmic RNA (hyRNA). Anti-Ro/SSA and anti-La/SSB antibodies are detected in 50 to 70 percent of primary Sjogren patients. Anti-Ro/SSA and anti-La/SSB antibodies are correlated with younger age at diagnosis, longer disease duration, more severe dysfunction of the exocrine glands, recurrent parotid gland enlargement and higher intensity of the lymphocytic infiltrates in the minor salivary glands." ; rdfs:label "Anti-La/SS-B antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0032236 obo:IAO_0000115 "An abnormally increased number of immature neutrophils in the peripheral blood circulation." ; dc:date "2019-01-26T17:21:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Various forms of immature neutrophils appear during granulopoiesis in the bone marrow. A seven day mitotic stage (myeloblast to promyelocyte to myelocyte) is followed by a seven day maturation stage (myelocyte to metamyelocyte to band cell to mature segmented neutrophil). Mature neutrophils are normally held in storage pools in the bone marrow before their entry into the circulation." ; rdfs:label "Increased circulating immature neutrophil count" ; rdfs:subClassOf obo:HP_0011991 . obo:HP_0032237 obo:IAO_0000115 "An abnormally increased number of myelocytes in the peripheral blood circulation. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and seconday granules, and a nucleus:cytoplasm ratio of 2:1." ; dc:date "2019-01-26T17:25:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating myelocyte count" ; rdfs:subClassOf obo:HP_0032236 . obo:HP_0032238 obo:IAO_0000115 "An abnormally increased number of metamyelocytes in the peripheral blood circulation. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with seconday granules, and a nucleus:cytoplasm ratio of 1.5:1." ; dc:date "2019-01-26T17:27:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating metamyelocyte count" ; rdfs:subClassOf obo:HP_0032236 . obo:HP_0032239 obo:IAO_0000115 "An abnormally increased number of band cells in the peripheral blood circulation. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small seconday granules, and a nucleus:cytoplasm ratio of 1:2." ; dc:date "2019-01-26T17:28:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating band form neutrophils", "Left shift" ; a owl:Class ; rdfs:label "Increased circulating band cell count" ; rdfs:subClassOf obo:HP_0032236 . obo:HP_0032240 obo:IAO_0000115 "An increased concentration of E selectin in the blood circulation." ; dc:date "2019-01-26T19:35:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating E selectin level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032241 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the uterine cervix." ; dc:date "2019-01-26T19:47:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cervical neoplasm" ; rdfs:subClassOf obo:HP_0007379, obo:HP_0012888 . obo:HP_0032242 obo:IAO_0000115 "A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer." ; dc:date "2019-01-26T19:49:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cervical intraepithelial neoplasia" ; rdfs:subClassOf obo:HP_0032241 . obo:HP_0032243 obo:IAO_0000115 "Any deviation from the normal concentration of a metabolite in a tissue." ; dc:date "2019-01-27T11:56:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal tissue metabolite concentration" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0032244 obo:IAO_0000115 "A reduction in the concentration of thromboxane B2 in the blood circulation." ; dc:date "2019-01-27T12:14:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased serum thromboxane B2" ; rdfs:subClassOf obo:HP_0030389 . obo:HP_0032245 obo:IAO_0000115 "An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products." ; dc:date "2019-01-27T12:48:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal metabolism" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0032247 obo:IAO_0000115 "Lasting (uncontrolled) presence of cytomegalovirus in the blood circulation." ; dc:date "2019-01-27T13:32:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Persistent CMV infection has important clinical relevance in the global population. Although immune-mediated control of CMV in healthy individuals prevents disease and overt clinical symptoms, immune dysregulation caused by immunosuppressive treatments in transplant and cancer patients, congenital immunodeficiencies, HIV/AIDS, and/or aging can result in CMV viremia, life threatening disease, and even death." ; rdfs:label "Persistent CMV viremia" ; rdfs:subClassOf obo:HP_0031692, obo:HP_0032248 . obo:HP_0032248 obo:IAO_0000115 "Persistence of virus in the blood circulation longer than would be normal in an immunocompentent host." ; dc:date "2019-01-27T13:36:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Persistent viremia" ; rdfs:subClassOf obo:HP_0020071, obo:HP_0032169 . obo:HP_0032249 obo:IAO_0000115 "Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species: Coccidioides immitis and C. posadasii." ; dc:date "2019-01-27T13:37:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Valley fever" ; a owl:Class ; rdfs:comment "Persons with immunodeficiency diseases, diabetics, transplant recipients, and prisoners are also particularly vulnerable to infection by Coccidioides." ; rdfs:label "Coccidioidomycosis" ; rdfs:subClassOf obo:HP_0032255 . obo:HP_0032250 obo:IAO_0000115 "An infection by Acinetobacter baumannii, a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has a high incidence among immunocompromised individuals, particularly those who have experienced a prolonged (over 90 d) hospital stay." ; dc:date "2019-01-27T16:38:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acinetobacter infection" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032251 dc:date "2019-01-27T16:44:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal immune system morphology" ; rdfs:subClassOf obo:HP_0002715 . obo:HP_0032252 obo:IAO_0000115 "A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis." ; dc:date "2019-01-27T16:44:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Granulomas vary considerably in their degree of complexity, physical size and organization. Not surprisingly, their classification has attracted much attention, and a numbers of schemes have been described. The cornerstone of the granulomatous response, however, is the predominant involvement of mononuclear phagocytes. As granulomas develop, tissue-resident, as well as inflammatory mononuclear phagocytes become intimately acquainted, and these cells may develop highly differentiated epithelioid cell characteristics. In many cases, elegant multinucleate populations can be seen, distinct from the syncytia formed after viral infection as evident by their extended life-span. Accumulating lymphocytes, mainly T cells, contribute to the developing microarchitecture of the granuloma, often with characteristic patterns of subset organization relative to the core of mononuclear phagocytes and to each other. B lymphocytes, plasma cells, NK cells and neutrophils may all be present, though a relative paucity of neutrophils delineates these sites of inflammation from those associated with necrosis. At its extreme, the granuloma may serve as the focus for irreversible fibrotic reactions, but, even in less dramatic cases, a substantive degree of local tissue remodelling occurs." ; rdfs:label "Granuloma" ; rdfs:subClassOf obo:HP_0032251 . obo:HP_0032253 obo:IAO_0000115 "A type of granuloma characterized morphologically by the predominance of Langerhans cells with characteristic grooved, folded, indented nuclei in the appropriate milieu that includes variable numbers of eosinophils and histiocytes including multinucleated forms, often appearing similar to osteoclasts or touton like giant cells, neutrophils and small lymphocytes. The concentration of the eosinophilic infiltrate varies from scattered mature cells to sheet-like masses of cells. Occasionally, areas of bone necrosis may interrupt the cellular infiltrate. The foamy cells may also be amassed in clumps, which are of no clinical significance because these clumps represent phagocytosis of lipid debris." ; dc:date "2019-01-27T16:50:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Eosinophilic granuloma (EG) is a benign disorder that affects children and young adults, particularly males. Solitary EG accounts for the majority of Langerhans cell histiocytosis cases, usually involving bone and less commonly the lymph nodes, lung or skin." ; rdfs:label "Eosinophilic granuloma" ; rdfs:subClassOf obo:HP_0032252 . obo:HP_0032254 obo:IAO_0000115 "An abnormally elevated concentration of copper in the blood circulation. This term refers to the total copper concentration." ; dc:date "2019-01-27T17:13:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated serum copper", "Hypercupremia" ; a owl:Class ; rdfs:label "Increased circulating copper concentration" ; rdfs:subClassOf obo:HP_0010836 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032255 obo:IAO_0000115 "An infection that is caused by a fungus that would generally not be able to cause an infection in a host with a normal immune system. Such fungi take advantage of the opportunity, so to speak, that is provided by a weakened immune system." ; dc:date "2019-01-27T18:09:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Opportunistic fungal infection" ; rdfs:subClassOf obo:HP_0020100, obo:HP_0031690 . obo:HP_0032256 obo:IAO_0000115 "Histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons." ; dc:date "2019-01-27T18:10:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Most patients exhibit pulmonary signs and symptoms, accompanied by radiographic abnormalities, which often are mistaken for community-acquired pneumonia caused by bacterial or viral agents. Most of the infected individuals remain asymptomatic or have very mild illness that does not get diagnosed as histoplasmosis. Significant symptoms develop in less than 1% of patients and most frequently present as pulmonary or disseminated histoplasmosis. Immunocompromised individuals, including patients with AIDS, hematologic malignancies, transplant recipients, and patients receiving prolonged steroids, are at higher risk of developing acute disseminated disease with a rapid and aggressive course." ; rdfs:label "Histoplasmosis" ; rdfs:subClassOf obo:HP_0032255 . obo:HP_0032257 obo:IAO_0000115 "Histoplasmosis infection involving multiple sites of the body. Disseminated histoplasmosis can involve various organs, including reticuloendothelial organs, gastrointestinal tract, adrenal glands, central nervous system, endovascular structures, kidney, and skin. It typically presents with systemic symptoms like fever, generalized fatigue, night sweats, weight loss, and the symptoms related to the specific organ involved. Severe disseminated disease can manifest as septic shock, multi organ failure, and ARDS." ; dc:date "2019-01-27T18:15:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated histoplasmosis" ; rdfs:subClassOf obo:HP_0032256 . obo:HP_0032258 obo:IAO_0000115 "Infection of the lungs with Histoplasma capsulatum. Symptoms may include fever, headache, weakness, chest pain and dry cough. When imaging is done, chest radiographs may show patchy pneumonia involving one or more lobes with adenopathy of the mediastinum or hilum." ; dc:date "2019-01-27T18:17:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary histoplasmosis" ; rdfs:subClassOf obo:HP_0032256 . obo:HP_0032259 obo:IAO_0000115 "The term tinea means fungal infection, whereas dermatophyte refers to the fungal organisms that cause tinea. This term refers to a tinea infection that is chronic or recalcitrant to treatment and may be reflective of an immune defect." ; dc:date "2019-01-27T18:30:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Tinea is usually followed by a Latin term that designates the involved site, such as tinea corporis and tinea pedis. Tinea versicolor (now called pityriasis versicolor) is not caused by dermatophytes but rather by yeasts of the genus Malassezia. Tinea unguium is more commonly known as onychomycosis. Dermatophytes are usually limited to involvement of hair, nails, and stratum corneum, which are inhospitable to other infectious agents. Dermatophytes include three genera: Trichophyton, Microsporum, and Epidermophyton." ; rdfs:label "Chronic tinea infection" ; rdfs:subClassOf obo:HP_0031035 . obo:HP_0032260 obo:IAO_0000115 "An infection that is caused by a bacterium that would generally not be able to cause an infection in a host with a normal immune system. Such bacteria take advantage of the opportunity, so to speak, that is provided by a weakened immune system." ; dc:date "2019-01-27T18:37:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Opportunistic bacterial infection" ; rdfs:subClassOf obo:HP_0031690 . obo:HP_0032261 obo:IAO_0000115 "An infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease." ; dc:date "2019-01-27T18:38:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Historically, human infections due to Mycobacterium were due almost exclusively to Mycobacterium tuberculosis (TB); the extensive societal impact of this infection is legendary. More recently, other species of mycobacterium causing clinical disease have been identified and, in many geographical regions, cause greater disease burden than TB. These organisms are referred to by a variety of collective names such as anonymous or atypical mycobacteria, mycobacteria other than tuberculosis (MOTT) and nontuberculous mycobacteria (NTM)." ; rdfs:label "Nontuberculous mycobacterial pulmonary infection" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032262 obo:IAO_0000115 "A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria." ; dc:date "2019-01-27T19:04:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary TB" ; a owl:Class ; rdfs:comment "Predisposing factors include poverty, social disruption, malnutrition, different causes of immune suppression, human immunodeficiency virus (HIV) infection, HIV-TB co-infection and increasing drug resistance." ; rdfs:label "Pulmonary tuberculosis" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032263 obo:IAO_0000115 "Abnormal increase in blood pressure. An individual measurement of increased blood pressure does not necessarily imply hypertension. In practical terms, multiple measurements are recommended to diagnose the presence of hypertension." ; dc:date "2019-01-27T20:07:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased BP" ; a owl:Class ; rdfs:label "Increased blood pressure" ; rdfs:subClassOf obo:HP_0030972 . obo:HP_0032264 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor." ; dc:date "2019-01-27T20:12:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Presence of anti-N-methyl-D-aspartate Receptor antibody in blood", "Presence of anti-NMDAR antibody in blood" ; a owl:Class ; rdfs:label "Anti-NMDA receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032265 obo:IAO_0000115 "The presence of an antibody in the cerebrospinal fluid (CSF) that is directed against the organism's own cells or tissues." ; dc:date "2019-01-27T20:13:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cerebrospinal fluid autoimmune antibody positivity" ; a owl:Class ; rdfs:label "CSF autoimmune antibody positivity" ; rdfs:subClassOf obo:HP_0002960 . obo:HP_0032266 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the cerebrospinal fluid (CSF) that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor." ; dc:date "2019-01-27T20:14:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Presence of NMDAR antibody in CSF", "Presence of anti-N-methyl-D-aspartate Receptor antibody in CSF", "Presence of anti-NMDAR antibody in cerebrospinal fluid" ; a owl:Class ; rdfs:label "CSF anti-NMDA receptor antibody positivity" ; rdfs:subClassOf obo:HP_0032265 . obo:HP_0032267 obo:IAO_0000115 "This sign is created by a nonenhancing thrombus in the dural sinus surrounded by triangular enhancing dura as seen on cross-section. The sign, seen on contrast-enhanced CT scan images, suggests dural sinovenous thrombosis. It is best seen on wider window settings. It is a reliable sign of sinus thrombosis but is seen only in 25-30% of these cases." ; dc:date "2019-01-27T20:21:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The use of multislice contrast-enhanced CT scan, with reconstructions into thinner slices in different planes, markedly improves the yield. The sign may not be seen in the early stage (less than 5 days) of thrombosis, as the fresh clot is hyperdense, or in the late stage (after more than 2 months), as numerous channels of recanalization develop in the thrombus after 2 months. See figure 5 in PMID:29089832." ; rdfs:label "Empty delta sign" ; rdfs:subClassOf obo:HP_0010303 . obo:HP_0032268 obo:IAO_0000115 "This sign represents thickening and enhancement of the dura mater in continuity with a mass, which on MR images, gives the appearance of a tail arising from the mass. The dural tail is thought to represent reactive change; however, it may also be due to tumor invasion. Three criteria need to be met for a positive dural tail sign: the tail should be seen on two successive images through the tumor, it should taper away from the tumor, and it must enhance more than the tumor." ; dc:date "2019-01-27T20:24:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This sign has been traditionally considered as highly specific for meningioma. However, it is seen only in 60% of meningiomas and has also been reported in nonmeningiomatous lesions such as chloromas, primary CNS lymphomas, sarcoidosis, schwannomas, metastases, and syphilitic gummata." ; rdfs:label "Dural tail sign" ; rdfs:subClassOf obo:HP_0010303 . obo:HP_0032269 obo:IAO_0000115 "The lemon sign refers to the shape of the fetal skull at ultrasonography (US) when the frontal bones lose their normal convex contour and appear flattened or inwardly scalloped. This gives the skull a shape that is said to resemble a lemon.. The sign is seen on transverse sonograms of the fetal cranium obtained at the level of the ventricles." ; dc:date "2019-01-27T20:27:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This sign represents the loss of the normal convex contour of the frontal bones, with flattening or inward scalloping, seen on a transverse fetal sonogram obtained at the biparietal diameter level. It has a strong association with spina bifida and is very useful for detecting this condition before 24 weeks of gestation in high-risk patients. It has high sensitivity and specificity. The lemon sign may disappear as gestational age advances and hence it is less reliable after 24 weeks. The sign is not specific for spina bifida and has also been seen in encephalocele, Dandy-Walker malformation with encephalocele, thanatophoric dysplasia, cystic hygroma, diaphragmatic hernia, corpus callosal agenesis, hydronephrosis, and umbilical vein varix." ; rdfs:label "Lemon sign" ; rdfs:subClassOf obo:HP_0025662 . obo:HP_0032270 obo:IAO_0000115 "A tram-track sign is composed of two enhancing areas of tumor separated from each other by the negative defect of the optic nerve. It is seen on contrast-enhanced CT scan and MRI images, in optic nerve sheath meningioma. The sign helps distinguish between optic nerve sheath meningioma and optic glioma. Optic glioma arises from glial cells within the optic nerve and there is no clear separation between the nerve and the tumor; hence the tram-track sign is not seen in optic gliomas. Calcification may be seen in optic nerve sheath meningiomas in 20-50% of cases and hence the tram-track sign may be seen on nonenhanced CT scan images as a linear calcification around the nerve, but this is less common." ; dc:date "2019-01-27T20:29:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Optic nerve tram-track sign" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0032271 obo:IAO_0000115 "A type of tubercular infection located outside of the lung, which is the most common location of tuberculosis. There are two types of clinical manifestation of tuberculosis (TB) are pulmonary TB (PTB) and extrapulmonary TB (EPTB). The former is most common. EPTB refers to TB involving organs other than the lungs (e.g., pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges). A patient with both pulmonary and EPTB is classified as a case of PTB." ; dc:date "2019-01-27T20:39:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Extrapulmonary TB" ; a owl:Class ; rdfs:comment "Extrapulmonary involvement can be seen in patients with concurrent AIDS and tuberculosis. The risk of extrapulmonary tuberculosis and mycobacteremia increases with advancing immunosuppression." ; rdfs:label "Extrapulmonary tuberculosis" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032272 obo:IAO_0000115 "Elevated N-acetylaspartic acid (NAA) in urine. This feature can be measured using gas chromatography-mass spectrometry." ; dc:date "2019-01-27T21:01:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Although NAA concentration is also elevated in the blood and cerebrospinal fluid (CSF) of children with neonatal/infantile (severe) Canavan disease, elevated concentration of NAA in urine is sufficient for diagnosis of affected individuals." ; rdfs:label "Elevated urinary N-acetylaspartic acid level" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0032273 obo:IAO_0000115 "Concentration of N-acetylaspartic acid in the blood circulation above the upper limit of normal." ; dc:date "2019-01-27T21:06:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating N-acetyl aspartate level", "Increased circulating N-acetyl aspartic acid level", "Increased circulating N-acetyl-L-aspartic acid level", "Increased circulating N-acetylaspartate level", "Increased circulating NAA level" ; a owl:Class ; rdfs:label "Increased circulating N-acetylaspartic acid concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0032274 obo:IAO_0000115 "An abnormally increased concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF)." ; dc:date "2019-01-27T21:07:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased N-acetyl aspartate levels in CSF", "Increased N-acetyl aspartic acid levels in CSF", "Increased N-acetyl-L-aspartic acid levels in CSF", "Increased N-acetylaspartate levels in CSF", "Increased NAA levels in CSF" ; a owl:Class ; rdfs:label "Increased CSF N-acetylaspartic acid concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0032275 obo:IAO_0000115 "Repeated episodes of a localized, painful cutaneous eruption related to reactivation of varicella zoster virus (VZV) and characterized by a characteristic rash in one or two adjacent dermatomes." ; dc:date "2019-01-27T21:15:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent shingles" ; rdfs:subClassOf obo:HP_0005353 . obo:HP_0032276 obo:IAO_0000115 "Abnormally increased prominence of the fat pad underneath the heal. This feature can be appreciated in figure 1 of PMID:26769062." ; dc:date "2019-01-27T21:38:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This pad normally protects the foot against the forces to which it is exposed during the ground contact phase of each step." ; rdfs:label "Prominent subcalcaneal fat pad" ; rdfs:subClassOf obo:HP_0001760 . obo:HP_0032277 dc:date "2019-01-27T21:47:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An ovoid depression of the tissue that immediately surrounds the umbilicus, resulting in a lozenge-shaped depression encircling a slightly prominent (protruding) umbilicus." ; rdfs:label "Lozenge-shaped umbilicus" ; rdfs:subClassOf obo:HP_0001551 . obo:HP_0032278 obo:IAO_0000115 "The concentration of 2-hydroxyglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2019-01-27T21:55:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "2-hydroxyglutaric aciduria can cause causes progressive cerebral damage." ; rdfs:label "2-hydroxyglutarate aciduria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0032281 obo:IAO_0000115 "Deviation from the normal quantity of base excess, defined as the amount of strong acid (in millimoles per liter) that needs to be added in vitro to 1 liter of fully oxygenated whole blood to return a blood sample to standard conditions (pH of 7.40, Pco2 of 40 mm Hg, and temperature of 37 degrees C)." ; dc:date "2019-01-27T23:07:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The base excess increases in metabolic alkalosis and decreases in metabolic acidosis, but its utility in interpreting blood gas results is controversial. The term base excess is used in clinical practice, but the available blood gas devices calculate either the standard base excess, also called the base excess of the extracellular fluid, or the base excess of blood. Base deficit is calculated as the base excess times minus one." ; rdfs:label "Abnormal base excess" ; rdfs:subClassOf obo:HP_0004360 . obo:HP_0032282 obo:IAO_0000115 "An inflammatory process in skin caused by an exogenous agent that directly or indirectly injure the skin. If the offending agent is identified and removed, the eruption will resolve. An unusual or patterned eruption may be a clue to the presence of a contact dermatitis. Patch testing may be helpful in the differential diagnosis." ; dc:date "2019-01-27T23:19:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Contact dermatitis" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0032283 obo:IAO_0000115 "An infection with nontuberculous mycobacteria that affects multiple body sites. Such infections can occur in individuals with immune disease." ; dc:date "2019-01-27T23:26:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disseminated nontuberculous mycobacterial infection" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032284 obo:IAO_0000115 "Ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm)." ; dc:date "2019-02-10T13:52:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ultra-low vision with retained motion projection" ; rdfs:subClassOf obo:HP_0032123 . obo:HP_0032285 obo:IAO_0000115 "Ultra-low vision but with retained ability to perceive the difference between light and dark. Also when light is projected in each of the four quadrants of the visual field, the individual is able to correctly identify the origin of the light stimulus." ; dc:date "2019-02-10T13:53:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ultra-low vision with retained light projection" ; rdfs:subClassOf obo:HP_0032123 . obo:HP_0032286 obo:IAO_0000115 "Ultra-low vision but with retained ability to perceive the difference between light and dark." ; dc:date "2019-02-10T13:54:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ultra-low vision with retained light perception" ; rdfs:subClassOf obo:HP_0032123 . obo:HP_0032287 obo:IAO_0000115 "Ultra-low vision with complete lack of light and form perception." ; dc:date "2019-02-10T13:55:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ultra-low vision with no light perception" ; rdfs:subClassOf obo:HP_0032123 . obo:HP_0032288 obo:IAO_0000115 "An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains." ; dc:date "2019-02-12T22:19:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polyclonal elevation of circulating IgG" ; rdfs:subClassOf obo:HP_0003237 . obo:HP_0032289 obo:IAO_0000115 "An increase in circulating immunoglobulins characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-12T22:23:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oligoclonal elevation of circulating IgG" ; rdfs:subClassOf obo:HP_0003237 . obo:HP_0032290 obo:IAO_0000115 "An increase in circulating immunoglobulins characterized by a single band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-12T22:37:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Monoclonal gammopathies are associated with a clonal process that is malignant or potentially malignant. In contrast, polyclonal gammopathies may be caused by any reactive or inflammatory process, and they usually are associated with nonmalignant conditions." ; rdfs:label "Monoclonal elevation of IgG" ; rdfs:subClassOf obo:HP_0003237 . obo:HP_0032291 obo:IAO_0000115 "A type of monoclonal elevation of IgG in which the involved immunoglobulin has a normal structure with a light and heavy chain." ; dc:date "2019-02-12T22:39:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of intact IgG" ; rdfs:subClassOf obo:HP_0032290 . obo:HP_0032292 obo:IAO_0000115 "A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a light chain but not a heavy chain." ; dc:date "2019-02-12T22:41:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Each monomeric IgG antibody consists of four chains: two heavy chains, providing class specificity, and two light chains, kappa or lambda." ; rdfs:label "Monoclonal elevation of IgG light chain" ; rdfs:subClassOf obo:HP_0032290 . obo:HP_0032293 obo:IAO_0000115 "A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a heavy chain but not a light chain." ; dc:date "2019-02-12T22:42:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of IgG heavy chain" ; rdfs:subClassOf obo:HP_0032290 . obo:HP_0032294 obo:IAO_0000115 "A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a kappa light chain but not a heavy chain." ; dc:date "2019-02-12T22:42:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of IgG kappa chain" ; rdfs:subClassOf obo:HP_0032292 . obo:HP_0032295 obo:IAO_0000115 "A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a lambda light chain but not a heavy chain." ; dc:date "2019-02-12T22:43:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of IgG lambda chain" ; rdfs:subClassOf obo:HP_0032292 . obo:HP_0032296 obo:IAO_0000115 "An elevation of circulating IgG level predominantly related to an elevation of one of the four IgG subclasses." ; dc:date "2019-02-12T22:46:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both IgG-Fc receptors (Fc-gammaR) and C1q. As a result, the different subclasses have different effector functions," ; rdfs:label "Increased circulating IgG subclass" ; rdfs:subClassOf obo:HP_0003237 . obo:HP_0032297 obo:IAO_0000115 "An abnormally increased concentration of the IgG3 subtype in the blood circulation." ; dc:date "2019-02-12T22:50:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "IgG3 antibodies are particularly effective in the induction of effector functions." ; rdfs:label "Increased circulating IgG3 level" ; rdfs:subClassOf obo:HP_0032296 . obo:HP_0032298 obo:IAO_0000115 "An abnormally increased concentration of the IgG1 subtype in the blood circulation." ; dc:date "2019-02-12T22:52:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Antibody responses to soluble protein antigens and membrane proteins primarily induce IgG1, but are accompanied with lower levels of the other subclasses, mostly IgG3 and IgG4. Because IgG1 is normally the most abundant subclass, a lack of IgG1 seen in a variety of primary and secondary antibody deficiencies, can result in decreased total IgG levels (hypogammaglobulinemia). IgG1 deficiencies, sometimes in combination with other IgG subclass deficiencies, are associated with recurrent infections." ; rdfs:label "Increased circulating IgG1 level" ; rdfs:subClassOf obo:HP_0032296 . obo:HP_0032299 obo:IAO_0000115 "An abnormally increased concentration of the IgG2 subtype in the blood circulation." ; dc:date "2019-02-12T22:55:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Immunoglobulin G-antibody responses to bacterial capsular polysaccharide antigens can be almost completely restricted to IgG2." ; rdfs:label "Increased circulating IgG2 level" ; rdfs:subClassOf obo:HP_0032296 . obo:HP_0032300 obo:IAO_0000115 "An abnormally increased concentration of the IgG4 subtype in the blood circulation." ; dc:date "2019-02-12T22:56:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Allergens are often good inducers of IgG1 and IgG4, in addition to IgE. IgG4 antibodies are often formed following repeated or long-term exposure to antigen in a non-infectious setting and may become the dominant subclass." ; rdfs:label "Increased circulating IgG4 level" ; rdfs:subClassOf obo:HP_0032296 . obo:HP_0032301 obo:IAO_0000115 "Warts affecting the skin in the genital area (peniile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pdenuculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress." ; dc:date "2019-02-12T23:10:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Genital warts are the clinical manifestations of a sexually transmitted disease caused by some types of human papillomavirus (HPV)." ; rdfs:label "Genital warts" ; rdfs:subClassOf obo:HP_0200043 . obo:HP_0032302 obo:IAO_0000115 "The presence of free monoclonal kappa immunoglobulin light chains in the urine." ; dc:date "2019-02-12T23:22:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Kappa Bence Jones proteinuria" ; rdfs:subClassOf obo:HP_0030156 . obo:HP_0032303 obo:IAO_0000115 "The presence of free monoclonal lambda immunoglobulin light chains in the urine." ; dc:date "2019-02-12T23:23:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lambda Bence Jones proteinuria" ; rdfs:subClassOf obo:HP_0030156 . obo:HP_0032304 obo:IAO_0000115 "Any deviation from the normal concentration of mannose-binding protein in the blood circulation." ; dc:date "2019-02-12T23:27:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mannose-binding protein is encoded by the MBL2 gene. It is a calcium-dependent lectin involved in innate immune defense and that binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway." ; rdfs:label "Abnormal circulating mannose-binding protein concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032305 obo:IAO_0000115 "Concentration of mannose-binding protein in the blood circulation below the lower limit of normal." ; dc:date "2019-02-12T23:29:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased mannose-binding protein level" ; a owl:Class ; rdfs:label "Decreased circulating mannose-binding protein concentration" ; rdfs:subClassOf obo:HP_0032304 . obo:HP_0032306 obo:IAO_0000115 "Concentration of mannose-binding protein in the blood circulation above the upper limit of normal." ; dc:date "2019-02-12T23:29:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased mannose-binding protein level" ; a owl:Class ; rdfs:label "Increased circulating mannose-binding protein concentration" ; rdfs:subClassOf obo:HP_0032304 . obo:HP_0032308 obo:IAO_0000115 "An elevated concentration of procalcitonin in the blood circulation." ; dc:date "2019-02-14T10:46:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating procalcitonin level" ; a owl:Class ; rdfs:comment "Procalcitonin is a 116 amino acid peptide that has an approximate MW of 14.5 kDa and belongs to the calcitonin (CT) superfamily of peptides. It can be divided into 3 sections including the amino terminus of the PCT region, immature calcitonin, and calcitonin carboxyl-terminus peptide-1 (CCP-1). Procalcitonin is encoded by CALC-1 gene located on chromosome 11. Cleavage in 1 site of the primary transcript of CALC-1 gene produces pre-PCT, which further undergoes proteolytic cleavage of its signal sequence to produce PCT. The synthesized PCT then undergoes post-translational processing to produce small peptides and mature CT. PCT is a biomarker that exhibits greater specificity than other proinflammatory markers (eg, cytokines) in identifying patients with sepsis and can be used in the diagnosis of bacterial infections. The short half-life (25-30 hours in plasma) of PCT, coupled with its virtual absence in health and specificity for bacterial infections, gives it a clear advantage over the other markers of bacterial infection." ; rdfs:label "Increased circulating procalcitonin concentration" ; rdfs:subClassOf obo:HP_0100530 . obo:HP_0032309 obo:IAO_0000115 "Any deviation from the normal cell count per volume of granulocytes in the blood circulation." ; dc:date "2019-02-14T10:54:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Granulocytes belong to the innate immune system and make up the largest proportion of white blood cells. They are myeloid cells and can be classified as neutrophil granulocytes (neutrophils), eosinophils, basophils, monocytes, and mast cells." ; rdfs:label "Abnormal granulocyte count" ; rdfs:subClassOf obo:HP_0001911, obo:HP_0011893 . obo:HP_0032310 obo:IAO_0000115 "An increased count of granulocytes in the peripheral blood circulation." ; dc:date "2019-02-14T10:57:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Granulocytosis" ; rdfs:subClassOf obo:HP_0032309 . obo:HP_0032311 obo:IAO_0000115 "An abnormally elevated concentration of globulins in the blood." ; dc:date "2019-02-14T11:01:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating globulin level" ; rdfs:subClassOf obo:HP_0032179 . obo:HP_0032312 obo:IAO_0000115 "An abnormally reduced concentration of globulins in the blood." ; dc:date "2019-02-14T11:02:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating globulin level" ; rdfs:subClassOf obo:HP_0032179 . obo:HP_0032313 obo:IAO_0000115 "Excessive, increased hair growth located in the region of the forehead and temple." ; dc:date "2019-02-14T11:05:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Frontotemporal hypertrichosis" ; rdfs:subClassOf obo:HP_0002219 . obo:HP_0032314 obo:IAO_0000115 "An abnormal appearance or structure of the ring of pigmented skin that surrounds the nipple." ; dc:date "2019-02-14T11:26:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal areolar morphology" ; rdfs:subClassOf obo:HP_0031093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032315 obo:IAO_0000115 "The areola (ring of pigmented skin surrounding the nipple) is filled out so as to produce a rounded shape." ; dc:date "2019-02-14T11:27:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Areolar fullness" ; rdfs:subClassOf obo:HP_0032314 . obo:HP_0032316 obo:IAO_0000115 "Information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins." ; dc:date "2019-02-14T11:40:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This subontology is intended to help record summary information about family members if only a limited amount of information is available or required." ; rdfs:label "Family history" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0032317 obo:IAO_0000115 "A close blood relative had cancer." ; dc:date "2019-02-14T11:43:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Family history of cancer" ; rdfs:subClassOf obo:HP_0032316 . obo:HP_0032318 obo:IAO_0000115 "A close blood relative had heart disease." ; dc:date "2019-02-14T11:45:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Family history of heart disease" ; rdfs:subClassOf obo:HP_0032316 . obo:HP_0032319 obo:IAO_0000115 "Health status of a family member with respect to the disease being investigated in a proband." ; dc:date "2019-02-14T11:46:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Health status" ; rdfs:subClassOf obo:HP_0032316 . obo:HP_0032320 obo:IAO_0000115 "This term applies to a family member who is diagnosed with the same condition as the individual who is the primary focus of investigation (the proband)." ; dc:date "2019-02-14T11:47:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Affected" ; rdfs:subClassOf obo:HP_0032319 . obo:HP_0032321 obo:IAO_0000115 "This term applies to a family member in whom the diagnosis that is the primary focus of investigation is excluded." ; dc:date "2019-02-14T11:48:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unaffected" ; rdfs:subClassOf obo:HP_0032319 . obo:HP_0032322 obo:IAO_0000115 "No history of any serious disease, including the disease being investigated in the proband." ; dc:date "2019-02-14T11:49:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Healthy" ; rdfs:subClassOf obo:HP_0032319 . obo:HP_0032323 obo:IAO_0000115 "Episodic fever that recurs at regular intervals." ; dc:date "2019-02-14T11:54:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periodic fever" ; rdfs:subClassOf obo:HP_0001954 . obo:HP_0032324 obo:IAO_0000115 "Episodic fever that recurs at irregular intervals." ; dc:date "2019-02-14T11:54:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Non-periodic recurrent fever" ; rdfs:subClassOf obo:HP_0001954 . obo:HP_0032325 obo:IAO_0000115 "A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain." ; dc:date "2019-02-14T11:57:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lacunar stroke" ; rdfs:subClassOf obo:HP_0002140 . obo:HP_0032326 obo:IAO_0000115 "Infection with staphylococcus aureus resistant to the antibiotic methicillin (MRSA). MRSA can infect any individual but is more common among hospitalized patients, and can also occur as an opportunistic infection." ; dc:date "2019-02-14T12:04:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "MRSA infection" ; a owl:Class ; rdfs:label "Methicillin-resistant Staphylococcus aureus infection" ; rdfs:subClassOf obo:HP_0032260 . obo:HP_0032327 obo:IAO_0000115 "Cystic collection (sac-like, fluid containing pocket of membranous tissue) located in the interhemispheric fissure, with or without communication with the ventricular system." ; dc:date "2019-02-16T14:47:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interhemispheric cyst" ; rdfs:subClassOf obo:HP_0012703 . obo:HP_0032328 obo:IAO_0000115 "Formation of one or more fibrous bands within the temporomandibular joint (TMJ) with resulting limitation of movement of the TMJ. Adhesions may be seen in degenerative processes that involve the TMJ." ; dc:date "2019-02-18T11:34:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:19534789." ; rdfs:label "Temporomandibular joint adhesion" ; rdfs:subClassOf obo:HP_0010754 . obo:HP_0032329 obo:IAO_0000115 "An abnormally elevated concentration of 11-deoxycortisol in the urine." ; dc:date "2019-02-18T13:41:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Increased urinary 11-Deoxycortisol is associated with congenital adrenal hyperplasia due to 11 beta-hydroxylase (CYP11B1) deficiency." ; rdfs:label "Increased urinary 11-deoxycortisol level" ; rdfs:subClassOf obo:HP_0012029 . obo:HP_0032330 obo:IAO_0000115 "An abnormally elevated concentration or amount of 11-deoxycorticosterone in the urine." ; dc:date "2019-02-18T13:52:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Increased urinary 11-deoxycorticosterone is associated with congenital adrenal hyperplasia due to 11 beta-hydroxylase (CYP11B1) deficiency." ; rdfs:label "Increased urinary 11-deoxycorticosterone level" ; rdfs:subClassOf obo:HP_0012029 . obo:HP_0032331 obo:IAO_0000115 "An abnormally elevated concentration or amount of 11-deoxytetrahydrocorticosterone the urine." ; dc:date "2019-02-18T13:59:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Increased urinary 11-deoxytetrahydrocorticosterone is associated with congenital adrenal hyperplasia due to 11 beta-hydroxylase (CYP11B1) deficiency." ; rdfs:label "Increased urinary 11-deoxytetrahydrocorticosterone level" ; rdfs:subClassOf obo:HP_0012029 . obo:HP_0032332 obo:IAO_0000115 "An increase in circulating IgM characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase." ; dc:date "2019-02-18T14:07:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oligoclonal elevation of circulating IgM" ; rdfs:subClassOf obo:HP_0003496 . obo:HP_0032333 obo:IAO_0000115 "A heterogeneous increase in IgA mmunoglobulins characterized by a diffuse band on serum electrophoresis." ; dc:date "2019-02-18T14:10:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polyclonal elevation of circulating IgA" ; rdfs:subClassOf obo:HP_0003261 . obo:HP_0032334 obo:IAO_0000115 "An increase in circulating IgA characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-18T14:10:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oligoclonal elevation of circulating IgA" ; rdfs:subClassOf obo:HP_0003261 . obo:HP_0032335 obo:IAO_0000115 "An increase in circulating IgA characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-18T14:10:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of circulating IgA" ; rdfs:subClassOf obo:HP_0003261 . obo:HP_0032336 dc:date "2019-02-18T14:13:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating specific IgE antibody" ; rdfs:subClassOf obo:HP_0010701 . obo:HP_0032337 obo:IAO_0000115 "An increase in circulating IgE characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-18T14:15:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monoclonal elevation of circulating IgE" ; rdfs:subClassOf obo:HP_0003212 . obo:HP_0032338 obo:IAO_0000115 "An increase in circulating IgE characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins." ; dc:date "2019-02-18T14:16:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oligoclonal elevation of circulating IgE" ; rdfs:subClassOf obo:HP_0003212 . obo:HP_0032339 obo:IAO_0000115 "A heterogeneous increase in IgE mmunoglobulins characterized by a diffuse band on serum electrophoresis." ; dc:date "2019-02-18T14:16:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polyclonal elevation of circulating IgE" ; rdfs:subClassOf obo:HP_0003212 . obo:HP_0032340 obo:IAO_0100001 "HP:0030878" ; dc:date "2019-02-21T12:38:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal spirometry test" ; owl:deprecated true . obo:HP_0032341 obo:IAO_0000115 "An abnormal reduction in the amount of air a person can expel following maximal inspiration." ; dc:date "2019-02-21T12:48:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased forced vital capacity", "Reduced FVC" ; a owl:Class ; rdfs:comment "The threshold for an abnormally low FVC is defined as less than the LLN for adults or less than 80 percent of predicted for those five to 18 years of age, indicating a restrictive pattern. The LLLN (lower limit of normal) is a measurement less than the fifth percentile of spirometry data obtained from the Third National Health and Nutrition Examination Survey (NHANES III)." ; rdfs:label "Reduced forced vital capacity" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0032342 obo:IAO_0000115 "An abnormal reduction in the amount of air a person can forcefully expel in one second." ; dc:date "2019-02-21T12:54:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced FEV1" ; a owl:Class ; rdfs:label "Reduced forced expiratory volume in one second" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0032344 obo:IAO_0000115 "Upturned concavity of toenails." ; dc:date "2019-02-21T13:14:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ski-jump toenail", "Upturned toenail" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:25776851." ; rdfs:label "Upslanting toenail" ; rdfs:subClassOf obo:HP_0008388 . obo:HP_0032345 obo:IAO_0000115 "An abnormal increased in the amount of the carbohydrate antigen 19-9, a recognizable sialo-ganglioside in the blood circulation." ; dc:date "2019-02-21T13:26:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "CA 19-9 is also referred to as sialyl Lewis-a (sLea). It is expressed on the surface of cancer cells as a glycolipid and as an O-linked glycoprotein. Subsequently, CA 19-9 was also identified in the tissue and sera of patients with other gastrointestinal tumors including esophageal, gastric, biliary and pancreatic cancer. CA 19-9 is derived from an aberrant pathway during production of its normal counterpart disialyl Lewis-a which has one extra sialic acid residue attached through a 2-to-6 linkage. Disialyl Lewis-a is normally expressed on the epithelial surface of digestive organs, serves as a ligand for monocytes and macrophages, and helps in immunosurveillance. Epigenetic silencing of the gene for 2-to-6 sialyl transferase during early stages of carcinogenesis leads to abnormal synthesis and accumulation of sialyl Lewis-a (CA 19-9)." ; rdfs:label "Elevated cancer Ag 19-9 level" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0032346 obo:IAO_0000115 "Lichen amyloidosis presents with multiple localized or rarely generalized, hyperpigmented grouped papules with a predilection for the shins, calves, ankles, and dorsa of the feet and thighs." ; dc:date "2019-02-23T16:20:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lichen amyloidosis is mostly associated with severe pruritus. It is a keratin-derived amyloidosis, in which cytokeratins serve as amyloid precursors, affecting only the dermis. Histological findings are grouped colloid bodies, which correspond to apoptotic basal keratinocytes." ; rdfs:label "Cutaneous lichen amyloidosis" ; rdfs:subClassOf obo:HP_0012309 . obo:HP_0032347 obo:IAO_0000115 "A type of cutaneous amyloidosis that is characterized by hyperpigmented patches with indefinite margins composed of grayish brown macules, often with a reticulated or rippled appearance." ; dc:date "2019-02-23T16:26:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Macular amyloidosis" ; a owl:Class ; rdfs:comment "Two types of keratotic amyloidosis have been identified: macular and lichen amyloidosis, and the latter is more common. In keratotic amyloidosis, keratin depositions originating from basal keratinocyte are mainly CK5 positive." ; rdfs:label "Cutaneous macular amyloidosis" ; rdfs:subClassOf obo:HP_0012309 . obo:HP_0032348 obo:IAO_0000115 "A type of cutaneous amyloidosis that is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue." ; dc:date "2019-02-23T16:30:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cutaneous nodular amyloidosis" ; rdfs:subClassOf obo:HP_0012309 . obo:HP_0032349 obo:IAO_0000115 "A increased concentration of serine in the urine." ; dc:date "2019-02-23T16:34:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Serinuria" ; rdfs:subClassOf obo:HP_0033099 . obo:HP_0032350 obo:IAO_0000115 "A increased concentration of sulfocysteine in the urine." ; dc:date "2019-02-23T16:43:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sulfocysteinuria" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0032351 obo:IAO_0000115 "Increased level of phenylalanine in urine." ; dc:date "2019-02-23T16:46:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of phenylalanine in urine" ; a owl:Class ; rdfs:label "Phenylalaninuria" ; rdfs:subClassOf obo:HP_0033090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032352 obo:IAO_0000115 "Level of methionine in urine above the upper limit of normal." ; dc:date "2019-02-23T16:48:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Methionine high in urine" ; a owl:Class ; rdfs:label "Methioninuria" ; rdfs:subClassOf obo:HP_0033095 . obo:HP_0032353 obo:IAO_0000115 "Increased level of leucine in urine." ; dc:date "2019-02-23T16:51:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Leucinuria" ; rdfs:subClassOf obo:HP_0033089 . obo:HP_0032355 obo:IAO_0000115 "A reduction in the maximum expiratory flow per minute, which can be used to measure how fast a subject can exhale as well as to judge the strength of the expiratory muscles and the condition of the large airways." ; dc:date "2019-02-23T16:59:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased peak expiratory flow" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0032356 obo:IAO_0000115 "An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed before the administration of a bronchodilating medication." ; dc:date "2019-02-23T17:02:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased pre bronchodilator forced vital capacity", "Decreased prebronchodilator forced vital capacity" ; a owl:Class ; rdfs:label "Decreased pre-bronchodilator forced vital capacity" ; rdfs:subClassOf obo:HP_0032341 . obo:HP_0032357 obo:IAO_0000115 "An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication." ; dc:date "2019-02-23T17:05:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased post bronchodilator forced vital capacity", "Decreased postbronchodilator forced vital capacity" ; a owl:Class ; rdfs:label "Decreased post-bronchodilator forced vital capacity" ; rdfs:subClassOf obo:HP_0032341 . obo:HP_0032358 obo:IAO_0000115 "An abnormal reduction in the amount of air a person can forcefully expel in one second, with the test being performed after the administration of a bronchodilating medication." ; dc:date "2019-02-23T17:09:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased post bronchodilator forced expiratory volume in one second", "Decreased postbronchodilator forced expiratory volume in one second" ; a owl:Class ; rdfs:label "Decreased post-bronchodilator forced expiratory volume in one second" ; rdfs:subClassOf obo:HP_0032342 . obo:HP_0032359 obo:IAO_0000115 "A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled." ; dc:date "2019-02-23T17:12:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased FEF25-75%" ; a owl:Class ; rdfs:label "Decreased forced expiratory flow 25-75%" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0032360 obo:IAO_0000115 "A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed before the administration of a bronchodilating medication." ; dc:date "2019-02-23T17:15:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased pre bronchodilator forced expiratory flow 25-75%", "Decreased pre-bronchodilator FEF25-75%", "Decreased prebronchodilator forced expiratory flow 25-75%" ; a owl:Class ; rdfs:label "Decreased pre-bronchodilator forced expiratory flow 25-75%" ; rdfs:subClassOf obo:HP_0032359 . obo:HP_0032361 obo:IAO_0000115 "A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed after the administration of a bronchodilating medication." ; dc:date "2019-02-23T17:19:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased post bronchodilator forced expiratory flow 25-75%", "Decreased post-bronchodilator FEF25-75%", "Decreased postbronchodilator forced expiratory flow 25-75%" ; a owl:Class ; rdfs:label "Decreased post-bronchodilator forced expiratory flow 25-75%" ; rdfs:subClassOf obo:HP_0032359 . obo:HP_0032362 obo:IAO_0000115 "An abnormally elevated concentration of corticosterone in the blood." ; dc:date "2019-02-23T17:25:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating corticosterone level" ; rdfs:subClassOf obo:HP_0012112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16827 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032363 obo:IAO_0000115 "An abnormally reduced concentration of corticosterone in the blood." ; dc:date "2019-02-23T17:31:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating corticosterone level" ; rdfs:subClassOf obo:HP_0012112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16827 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032364 obo:IAO_0100001 "HP:0500184" ; a owl:Class ; rdfs:label "obsolete Abnormal CSF amino acid level" ; owl:deprecated true . obo:HP_0032365 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by ingestion of aspirin." ; dc:date "2019-02-23T17:36:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by aspirin exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0032366 obo:IAO_0000115 "A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction." ; dc:date "2019-02-23T17:43:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The DAT is a method used to detect immunoglobulin or complement bound in vivo to RBCs, using anti-human reagents. There are 3 different reagents that may be used: monospecific reagents to detect either bound immunoglobulin G (IgG) or bound complement (C3) and polyspecific reagents that can simultaneously detect IgG and/or C3. In screening of RBCs for the presence of bound globulins and/or C3, many laboratories may choose to use the polyspecific reagent initially (ie, as a screen for any bound IgG and/or complement) and, if positive, subsequently use monospecific reagents to specifically distinguish what is bound to the RBC surface." ; rdfs:label "Positive direct antiglobulin test" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032367 obo:IAO_0000115 "Any deviation from the normal level of growth hormone (GH) in the blood circulation. GH or somatotropin is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration. Its secretion from the pituitary is regulated by the neurosecretory nuclei of the hypothalamus, which can release Growth hormone-releasing hormone (GHRH or somatocrinin) and Growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary. GH is secreted in a pulsatile manner, which is one of the reasons why an isolated measurement of its blood concentration is not meaningful." ; dc:date "2019-02-23T18:15:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal somatotropin level" ; a owl:Class ; rdfs:label "Abnormal growth hormone level" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0030252 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032368 obo:IAO_0000115 "An abnormally low blood pH (usually defined as less than 7.35)." ; dc:date "2019-02-23T18:37:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "When describing acid-base abnormalities, acidosis and alkalosis refer to physiological processes that lower or raise the pH, respectively, while acidemia and alkalemia simply describe the state of an abnormal blood pH. This distinction is important: a patient with acidemia could have both a respiratory and metabolic acidosis as well as a concurrent metabolic alkalosis." ; rdfs:label "Acidemia" ; rdfs:subClassOf obo:HP_0004360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_37527 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032369 obo:IAO_0000115 "An abnormally high blood pH (usually defined as 7.41 or above)." ; dc:date "2019-02-23T18:42:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "When describing acid-base abnormalities, acidosis and alkalosis refer to physiological processes that lower or raise the pH, respectively, while acidemia and alkalemia simply describe the state of an abnormal blood pH. This distinction is important: a patient with acidemia could have both a respiratory and metabolic acidosis as well as a concurrent metabolic alkalosis." ; rdfs:label "Alkalemia" ; rdfs:subClassOf obo:HP_0004360 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24431 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000087 ; owl:someValuesFrom obo:CHEBI_22695 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032370 obo:IAO_0000115 "ABO phenotype A, corresponding to the genotype AO or AA." ; dc:date "2019-02-23T18:59:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood group A" ; rdfs:subClassOf obo:HP_0032224 . obo:HP_0032371 obo:IAO_0000115 "An increased concentration of isoleucine in the urine." ; dc:date "2019-02-23T19:14:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperisoleucinuria", "Isoleucine high in urine" ; a owl:Class ; rdfs:label "Isoleucinuria" ; rdfs:subClassOf obo:HP_0033089 . obo:HP_0032372 obo:IAO_0000115 "An increased count in the peripheral blood of cells that are precursors to mature circulating blood cells such as neutrophiles, monocytes, lymphocutes, and erythrocytes. Blasts are not usually found in significant numbers in the peripheral blood circulation, but can be observed in hematopoietic neoplasms such as leukemia, severe infections, and as a result of certain medications." ; dc:date "2019-02-24T13:28:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated blast count", "Elevated circulating blasts", "Increased peripheral myeloblast count" ; a owl:Class ; rdfs:label "Increased peripheral blast count" ; rdfs:subClassOf obo:HP_0011893 . obo:HP_0032373 obo:IAO_0000115 "The Duffy blood group system is based on the presence of a glycoprotein termed Fy that is on the surface of erythrocytes and some other cells. There are two Duffy antigens named Fya and Fyb, and thus there are four Duffy phenotypes: a+b+, a+b-, a-b+,a-b-." ; dc:date "2019-02-24T13:37:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "FY has two major codominant alleles, FYA and FYB, which result from a SNP (125G>A), and the corresponding Fya and Fyb antigens differ by a single amino acid (G42D). Individuals who are homozygous for a -33T>C SNP in the erythroid promoter region of the FYB allele have the phenotype Fy(a-b-) and do not express Duffy antigens on their RBCs." ; rdfs:label "Duffy blood group" ; rdfs:subClassOf obo:HP_0032223 . obo:HP_0032374 obo:IAO_0000115 "Presence of the Duffy Fya antigen." ; dc:date "2019-02-24T13:40:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Duffy Fya positivity" ; rdfs:subClassOf obo:HP_0032373 . obo:HP_0032375 obo:IAO_0000115 "Presence of the Duffy Fyb antigen." ; dc:date "2019-02-24T13:42:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Duffy Fyb positivity" ; rdfs:subClassOf obo:HP_0032373 . obo:HP_0032376 obo:IAO_0000115 "Presence of antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS)." ; dc:date "2019-02-24T13:47:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-B2GPI positivity" ; a owl:Class ; rdfs:comment "Beta2GPI was identified as a primary target of autoantibodies in patients with APS. Beta2GPI is a single-chain protein containing five repeating sequences or domains. Domain V is essential for binding to anionic phospholipid membranes, whereas domain I sticks out into the extracellular space where interactions with other proteins/antibodies can take place 1." ; rdfs:label "Anti-beta 2 glycoprotein I antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032377 obo:IAO_0000115 "An increased concentration in the urine of alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM). AGP is a 41-43-kDa glycoprotein with a pI of 2.8-3.8. AGP is an acute-phase protein that has many activities including, but not limited to, acting as an acute-phase reactant and disease marker, modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism." ; dc:date "2019-02-24T14:04:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urinary alpha-1-acid glycoprotein" ; a owl:Class ; rdfs:label "Increased urinary orosomucoid" ; rdfs:subClassOf obo:HP_0020129 . obo:HP_0032378 obo:IAO_0000115 "Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching, dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement." ; dc:date "2019-02-24T14:43:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hypersensitivity is broadly defined as objectively reproducible symptoms or signs, initiated by exposure to a defined stimulus at a dose tolerated by normal subjects and may be caused by immunologic (allergic) and non-immunologic mechanisms." ; rdfs:label "Immediate-type hypersensitivity drug reaction" ; rdfs:subClassOf obo:HP_0100326 . obo:HP_0032379 obo:IAO_0000115 "The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces." ; dc:date "2019-02-24T14:52:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sun allergy" ; a owl:Class ; rdfs:label "Polymorphous light eruption" ; rdfs:subClassOf obo:HP_0000992 . obo:HP_0032381 obo:IAO_0000115 "In response to the spring sun distinct inflamed reddened skin develops on the ears, nose, cheeks, fingers, backs of the hands, and the lower arms, on which blisters with serous or hemorrhagic content develop. These dry out with the formation of a blackish scab. After shedding of the scab, depressed, varioliform, often hypopigmented scars remain. In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation." ; dc:date "2019-02-24T14:55:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acute vesiculation and crusting and scarring following sun exposure" ; a owl:Class ; rdfs:label "Hydroa vacciniforme" ; rdfs:subClassOf obo:HP_0000992 . obo:HP_0032382 obo:IAO_0000115 "Inheritance of both homologues of a chromosome pair from the same parent." ; dc:date "2019-02-24T14:58:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "UPD" ; a owl:Class ; rdfs:comment "UPD may comprise the whole chromosome, or just part of it (segmental UPD). Isodisomy is presented as 2 copies from the same chromosome of a parent, and heterodisomy is presented as 1 copy of each of the 2 homologues from the same parent. UPD is related to abnormalities formed during meiosis, fertilization, and mitosis. There are 5 different mechanisms that explain the etiology of UPD, including Trisomic rescue; Nullisomic gamete complementation; Monosomic rescue; Mitotic aberrations; and Structural chromosome aberrations. If prenatal genetic analysis reveals a homologous robertsonian translocation, the risk of fetal UPD is very high, and a marker chromosome or chromosome aneuploidy can be associated with UPD." ; rdfs:label "Uniparental disomy" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0032383 obo:IAO_0000115 "A type of uniparental disomy in which the two different chromosomes (or chromosome segments) of the same parent are transmitted." ; dc:date "2019-02-24T15:04:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uniparental heterodisomy" ; rdfs:subClassOf obo:HP_0032382 . obo:HP_0032384 obo:IAO_0000115 "A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted." ; dc:date "2019-02-24T15:05:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uniparental isodisomy" ; rdfs:subClassOf obo:HP_0032382 . obo:HP_0032385 obo:IAO_0000115 "Any deviation from the normal concentration of transferrin in the blood circulation." ; dc:date "2019-02-24T15:33:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating transferrin level" ; a owl:Class ; rdfs:label "Abnormal circulating transferrin concentration" ; rdfs:subClassOf obo:HP_0025465 . obo:HP_0032386 obo:IAO_0000115 "An abnormally increased concentration of transferrin in the blood circulation." ; dc:date "2019-02-24T15:34:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated transferrin level" ; a owl:Class ; rdfs:label "Elevated circulating transferrin concentration" ; rdfs:subClassOf obo:HP_0032385 . obo:HP_0032387 obo:IAO_0000115 "An abnormally decreased concentration of transferrin in the blood circulation." ; dc:date "2019-02-24T15:35:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced transferrin level" ; a owl:Class ; rdfs:label "Reduced circulating transferrin concentration" ; rdfs:subClassOf obo:HP_0032385 . obo:HP_0032388 obo:IAO_0000115 "Nodules of heterotopia along the ventricular walls. There can be a single nodule or a large number of nodules, they can exist on either or both sides of the brain at any point along the higher ventricle margins, they can be small or large, single or multiple." ; dc:date "2019-02-24T15:59:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periventricular nodular heterotopia" ; rdfs:subClassOf obo:HP_0007165 . obo:HP_0032389 obo:IAO_0000115 "A large mass of heterotopia in a laminar configuration along the ventricular walls. Usually bilateral." ; dc:date "2019-02-24T16:00:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periventricular laminar heterotopia" ; rdfs:subClassOf obo:HP_0007165 . obo:HP_0032390 obo:IAO_0000115 "Heterotopia that forms a continuous wavy line along the ventricular wall." ; dc:date "2019-02-24T16:02:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periventricular ribbonlike heterotopia" ; rdfs:subClassOf obo:HP_0007165 . obo:HP_0032391 obo:IAO_0000115 "A form of heterotopia were the mislocalized gray matter is located deep within the white matter." ; dc:date "2019-02-24T16:03:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subcortical heterotopia" ; rdfs:subClassOf obo:HP_0002282 . obo:HP_0032392 obo:IAO_0000115 "Solid nodular heterotopia situated in the region of the peritrigonal optic pathway posterior to the deep gray nuclei." ; dc:date "2019-02-24T16:05:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nodular subcortical heterotopia in peritrigonal regions" ; rdfs:subClassOf obo:HP_0032391 . obo:HP_0032393 obo:IAO_0000115 "Subcortical heterotopia consisting of a bilateral and symmetric single continuous, undulating ribbon-like layer of gray matter located in the frontal, parietal and occipital lobes. It has no visible connection to the overlying cortex." ; dc:date "2019-02-24T16:06:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diffuse ribbon-like subcortical heterotopia" ; rdfs:subClassOf obo:HP_0032391 . obo:HP_0032394 obo:IAO_0000115 "Subcortical heterotopia extending along the mesial aspect of the lateral ventricles, with direct connection to mesial polymicrogyria-like cortex at the anterior and posterior limits of the heterotopia." ; dc:date "2019-02-24T16:07:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This pattern is assocatied with Chudlely-McCullough syndrome." ; rdfs:label "Mesial parasagittal subcortical heterotopia" ; rdfs:subClassOf obo:HP_0032391 . obo:HP_0032395 obo:IAO_0000115 "Large subcortical heterotopia of variable morphology wiht streaks and swirls. These always connect to the overlying cortex in at least one, but usually in multiple, locations. Spaces with the signal intensity of CSF are usually seen within the heterotopia." ; dc:date "2019-02-24T16:08:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Giant heterotopia" ; a owl:Class ; rdfs:label "Curvilinear subcortical heterotopia" ; rdfs:subClassOf obo:HP_0032391 . obo:HP_0032396 obo:IAO_0000115 "Linear heterotopia spanning from the cerebral mantle from the pia to the ependyma." ; dc:date "2019-02-24T16:09:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transmantle columnar heterotopia" ; rdfs:subClassOf obo:HP_0032391 . obo:HP_0032397 obo:IAO_0000115 "An increased concentration of citrulline in the urine." ; dc:date "2019-02-24T16:59:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Citrulline high in urine" ; a owl:Class ; rdfs:comment "Citrulline is an alpha-amino acid that is a key intermediate in the urea cycle." ; rdfs:label "Citrullinuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0032398 obo:IAO_0000115 "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation." ; dc:date "2019-02-24T17:04:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Dysgyria translates as abnormal gyration and can therefore be applied to almost every type of MCD (malformations of cortical development). However, this term was introduced to describe cortical malformations that do not meet classic features of any of the abovementioned well-established MCD types. Dysgyria describes a cortex of variable thickness and an abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation (for example, obliquely oriented sulci directed radially towards the centre of the cerebrum and narrow gyri separated by abnormally deep or shallow sulci). In the vast majority of cases, the term dysgyria describes an abnormal non-lissencephaly, non-polymicrogyria cortex within the spectrum of tubulinopathies." ; rdfs:label "Dysgyria" ; rdfs:subClassOf obo:HP_0002269, obo:HP_0002536 . obo:HP_0032399 obo:IAO_0000115 "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation but with a normal thickness of the cortex." ; dc:date "2019-02-24T17:05:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dysgyria with normal cortical thickness" ; rdfs:subClassOf obo:HP_0032398 . obo:HP_0032400 obo:IAO_0000115 "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation and a thickened cortex intermediate between pachygyria and polymicrogyria." ; dc:date "2019-02-24T17:06:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dysgyria with thickened cortex" ; rdfs:subClassOf obo:HP_0006891, obo:HP_0032398 . obo:HP_0032401 obo:IAO_0000115 "A increased concentration of aspartic acid in the urine." ; dc:date "2019-02-24T17:47:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aspartic aciduria" ; rdfs:subClassOf obo:HP_0033096 . obo:HP_0032403 obo:IAO_0000115 "An increased concentration of asparagine in the urine." ; dc:date "2019-02-24T17:59:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of asparagine in urine", "Increased urine asparagine level" ; a owl:Class ; rdfs:label "Asparaginuria" ; rdfs:subClassOf obo:HP_0033096 . obo:HP_0032404 obo:IAO_0000115 "An abnormal bulge or lump in a testis. A testicular mass has a long differential diagnosis including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer." ; dc:date "2019-02-24T18:42:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The word mass is often used interchangeably with tumor, which derives from the Latin word tumor that originally meant any form of swelling. A small mass may be asymptomatic. Larger masses may cause pain if they press on a nerve or organ, or may lead to other manifestations depending on their location. In general, the finding of a mass will lead to a workup to determine the nature of the mass. More precise HPO terms should be used if possible. This term should be used only if the etiology has not yet been clarified." ; rdfs:label "Testicular mass" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0032405 obo:IAO_0000115 "An increased level of phosphoserine in the urine." ; dc:date "2019-02-24T20:26:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of phosphoserine in urine" ; a owl:Class ; rdfs:comment "O-phosphoserine is a serine derivative that is serine substituted at the oxygen atom by a phosphono group." ; rdfs:label "Increased urinary phosphoserine level" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0032406 obo:IAO_0000115 "A type of perisylvian polymicrogyria that largely affects one side of the brain." ; dc:date "2019-02-24T20:45:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unilateral perisylvian polymicrogyria" ; rdfs:subClassOf obo:HP_0006927, obo:HP_0012650 . obo:HP_0032407 obo:IAO_0000115 "A type of perisylvian polymicrogyria that affects both sides of the brain." ; dc:date "2019-02-24T20:47:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bilateral perisylvian polymicrogyria" ; rdfs:subClassOf obo:HP_0012650, obo:HP_0025646 . obo:HP_0032408 obo:IAO_0000115 "A breast lump is any discrete mass in a breast noticed by the patient, significant other, or physician." ; dc:date "2019-02-24T20:59:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Breast lump" ; a owl:Class ; rdfs:comment "The word mass is often used interchangeably with tumor, which derives from the Latin word tumor that originally meant any form of swelling. A small mass may be asymptomatic. Larger masses may cause pain if they press on a nerve or organ, or may lead to other manifestations depending on their location. In general, the finding of a mass will lead to a workup to determine the nature of the mass. The differential diagnosis of a breast mass includes fibrocystic disease, fibroadenomas, breast cancer, mammary duct ectasia, and intraductal papilloma." ; rdfs:label "Breast mass" ; rdfs:subClassOf obo:HP_0031093 . obo:HP_0032409 obo:IAO_0000115 "A form of subcortical heterotopia with mislocalized gray matter within the white matter.It is defined as longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter. It is part of the lissencephaly spectrum." ; dc:date "2019-02-24T21:08:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subcortical band heterotopia" ; rdfs:subClassOf obo:HP_0001339, obo:HP_0032391 . obo:HP_0032410 obo:IAO_0000115 "Symmetric generalized polymicrogyria with no obvious gradient or region of maximal severity; may have abnormal high signal in white matter." ; dc:date "2019-02-24T21:11:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bilateral generalised polymicrogyria", "Diffuse polymicrogyria" ; a owl:Class ; rdfs:label "Bilateral generalized polymicrogyria" ; rdfs:subClassOf obo:HP_0025646 . obo:HP_0032411 obo:IAO_0000115 "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the occipital cortex." ; dc:date "2019-02-24T21:13:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Occipital subcortical band heterotopia", "Subcortical band heterotopia posterior predominant" ; a owl:Class ; rdfs:label "Posterior predominant subcortical band heterotopia" ; rdfs:subClassOf obo:HP_0032409 . obo:HP_0032412 obo:IAO_0000115 "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible in the frontal and temporal lobes." ; dc:date "2019-02-24T21:22:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Frontal subcortical band heterotopia", "Subcortical band heterotopia anterior predominant" ; a owl:Class ; rdfs:label "Anterior predominant subcortical band heterotopia" ; rdfs:subClassOf obo:HP_0032409 . obo:HP_0032413 obo:IAO_0000115 "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the whole brain." ; dc:date "2019-02-24T21:25:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Subcortical band heterotopia diffuse" ; a owl:Class ; rdfs:label "Diffuse subcortical band heterotopia" ; rdfs:subClassOf obo:HP_0032409 . obo:HP_0032414 obo:IAO_0000115 "The presence of an elevated amount of 5-hydroxylysine in the urine. This compound is a hydroxylated derivative of the amino acid lysine that is present in certain collagens." ; dc:date "2019-02-24T21:34:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hydroxylysine high in urine" ; a owl:Class ; rdfs:label "Hydroxylysinuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0032415 obo:IAO_0000115 "Polymicrogyria in parasagittal and mesial aspects of parieto-occipital cortex." ; dc:date "2019-02-26T13:20:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Parasagittal parieto-occipital polymicrogyria" ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0032416 obo:IAO_0000115 "A localized dilation of microvasculature formed due to disruption of the internal elastic lamina of a retinal capillary blood vessel. The lesions present as small circular, red dots having distinct margins and are no larger than a blood vessel width at the disk margin. This expansion disturbs the normal flow pattern, changing shear force and pressure along the vessel. Shear force plays a key role in promoting the differentiation and proliferation of endothelial cells." ; dc:date "2019-02-26T13:58:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A microaneurysm may be a focal bulge or have a saccular, fusiform, or mixed appearance. Multiple microaneurysm may be observed in the fundus." ; rdfs:label "Retinal microaneurysm" ; rdfs:subClassOf obo:HP_0008046 . obo:HP_0032417 obo:IAO_0000115 "Circumferential fibrosis in the interstitium surrounding Bowman's capsule" ; dc:date "2019-02-26T14:20:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "PMID:32866505" ; oboInOwl:hasExactSynonym "Periglomerular fibrotic thickening" ; a owl:Class ; rdfs:comment "Periglomerular fibrosis is characterized by glomeruli with open capillaries, but lamellated, frequently wrinkled, Bowman capsular basement membrane and circumferential layers of interstitial-type collagen around, within, or between the usually thickened, frequently lamellated, Bowman capsule basement membrane." ; rdfs:label "Periglomerular fibrosis" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0032418 obo:IAO_0000115 "An abnormal concentration of an HDL subfraction, which can be determined by methods such as electrophoresis followed by densitometric determination of the areas under the peaks. Large HDL subfractions are defined as HDL1 (greater than 12 nm), HDL2b (9.7-12 nm), and HDL2a (8.8-9.69 nm). Small HDL subfractions are defined as HDL3a (8.2-8.79 nm), HDL3b (7.8-8.19 nm), and HDL3c (7.20-7.79 nm)." ; dc:date "2019-03-02T13:28:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Traditionally, HDL is separated into two major subclasses (HDL2 and HDL3), but depending on the separation method used, u[ to 10 subfractions have been reported." ; rdfs:label "Abnormal HDL subfraction concentration" ; rdfs:subClassOf obo:HP_0031888 . obo:HP_0032419 obo:IAO_0000115 "Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." ; dc:date "2019-03-02T13:30:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal HDL2a concentration" ; rdfs:subClassOf obo:HP_0032418 . obo:HP_0032420 obo:IAO_0000115 "An elevation above the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." ; dc:date "2019-03-02T13:40:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased HDL2a concentration" ; rdfs:subClassOf obo:HP_0032419 . obo:HP_0032421 obo:IAO_0000115 "A reduction below the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." ; dc:date "2019-03-02T13:41:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased HDL2a concentration" ; rdfs:subClassOf obo:HP_0032419 . obo:HP_0032422 obo:IAO_0000115 "Any deviation from the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." ; dc:date "2019-03-02T13:45:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal HDL2b concentration" ; rdfs:subClassOf obo:HP_0032418 . obo:HP_0032423 obo:IAO_0000115 "A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." ; dc:date "2019-03-02T13:46:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased HDL2b concentration" ; rdfs:subClassOf obo:HP_0032422 . obo:HP_0032424 obo:IAO_0000115 "An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." ; dc:date "2019-03-02T13:46:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased HDL2b concentration" ; rdfs:subClassOf obo:HP_0032422 . obo:HP_0032425 obo:IAO_0000115 "Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." ; dc:date "2019-03-02T13:48:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal HDL3a concentration" ; rdfs:subClassOf obo:HP_0032418 . obo:HP_0032426 obo:IAO_0000115 "Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." ; dc:date "2019-03-02T13:49:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal HDL3b concentration" ; rdfs:subClassOf obo:HP_0032418 . obo:HP_0032427 obo:IAO_0000115 "Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." ; dc:date "2019-03-02T13:49:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal HDL3c concentration" ; rdfs:subClassOf obo:HP_0032418 . obo:HP_0032428 obo:IAO_0000115 "An elevation above the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." ; dc:date "2019-03-02T13:49:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased HDL3a concentration" ; rdfs:subClassOf obo:HP_0032425 . obo:HP_0032429 obo:IAO_0000115 "A reduction below the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." ; dc:date "2019-03-02T13:49:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased HDL3a concentration" ; rdfs:subClassOf obo:HP_0032425 . obo:HP_0032430 obo:IAO_0000115 "An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." ; dc:date "2019-03-02T13:51:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased HDL3b concentration" ; rdfs:subClassOf obo:HP_0032426 . obo:HP_0032431 obo:IAO_0000115 "A reduction below the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." ; dc:date "2019-03-02T13:51:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased HDL3b concentration" ; rdfs:subClassOf obo:HP_0032426 . obo:HP_0032432 obo:IAO_0000115 "An elevation above the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." ; dc:date "2019-03-02T13:51:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased HDL3c concentration" ; rdfs:subClassOf obo:HP_0032427 . obo:HP_0032433 obo:IAO_0000115 "A reduction below the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." ; dc:date "2019-03-02T13:51:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased HDL3c concentration" ; rdfs:subClassOf obo:HP_0032427 . obo:HP_0032434 obo:IAO_0000115 "Separation of the umbilical cord occurs at an abnormally late timepoint." ; dc:date "2019-03-02T15:01:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Delayed separation of umbilical cord" ; a owl:Class ; rdfs:comment "The umbilical cord of the newborn usually separates and sloughs by the end of the second postnatal week. However, a wide variation exists in the age at which cord separation occurs in healthy infants with regard to ethnicity, geographical location, and methods of cord care. A marked delay in cord separation raises the suspicion of leukocyte adhesion deficiency, a rare disorder leading to defective neutrophil function." ; rdfs:label "Delayed umbilical cord separation" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0032435 obo:IAO_0000115 "An infection of the umbilicus and/or surrounding tissues occurring in the neonatal period." ; dc:date "2019-03-02T15:07:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Omphalitis", "Umbilical cord stump infection" ; a owl:Class ; rdfs:comment "The umbilical cord stump then gradually dries and typically falls off within 5 to 15 days. Both skin and enteric bacteria may colonize the devitalized tissue of the stump and lead to infection. Omphalitis is, therefore, a polymicrobial infection and the most common pathogens are Staphylococcus aureus, Streptococcus pyogenes, and gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis." ; rdfs:label "Neonatal omphalitis" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0032436 obo:IAO_0000115 "Any deviation from the normal concentration of C-reactive protein in the blood circulation." ; dc:date "2019-03-02T15:10:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal C-reactive protein level" ; a owl:Class ; rdfs:comment "C-reactive protein (CRP) is produced by the liver, and increases in concentration in response to inflammation." ; rdfs:label "Abnormal circulating C-reactive protein concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032437 obo:IAO_0000115 "An abnormal decrease of the C-reactive protein level in serum." ; dc:date "2019-03-02T15:11:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced C-reactive protein level" ; a owl:Class ; rdfs:label "Reduced circulating C-reactive protein concecntration" ; rdfs:subClassOf obo:HP_0032436 . obo:HP_0032438 obo:IAO_0000115 "Abnormally increased variability in the size of platelets." ; dc:date "2019-03-03T16:06:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Platelet anisocytosis" ; rdfs:subClassOf obo:HP_0011875 . obo:HP_0032439 obo:IAO_0000115 "An abnormally increased sensitivity to airborn particles. This can be diagnosed on the basis of the medical history, taking into account seasonality or a relationship to the concentration of airborn particles in the environment of the affected individual. Aerosol challenge is a gold standard of establishment of the symptom. There exist particle hypersensitivity (diesel exhaust, metals, inorganic material) vs. allergen (including pollen dander, etc) hypersensitivity. The responses are usually different and testing for allergen hypersensitivity is done in concert with serum IgE and or skin testing to the suspected allergen." ; dc:date "2019-03-03T16:15:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Particles can be defined as any small bits of material or droplets either inorganic or organic, viable or nonviable, that can become airborne. They can range from small molecules less than 0.001 micrometer to pollens and spores ranging between 2 and 50 micrometers and very large visible dust particles in the range of 1000 micrometers. Particles can also assume many shapes including long, fibrous varieties with a length greater than three times diameter, spheres, oddly shaped or irregularly shaped material, oblong, crescent-shaped varieties, or other peculiar shapes, such as certain pollen grains and mold spores." ; rdfs:label "Airborn particle hypersensitivity" ; rdfs:subClassOf obo:HP_0100326 . obo:HP_0032440 obo:IAO_0000115 "ABO phenotype B, corresponding to the genotype BO or BB." ; dc:date "2019-03-03T16:34:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood group B" ; rdfs:subClassOf obo:HP_0032224 . obo:HP_0032441 obo:IAO_0000115 "ABO phenotype AB, corresponding to the genotype AB." ; dc:date "2019-03-03T16:37:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood group AB" ; rdfs:subClassOf obo:HP_0032224 . obo:HP_0032442 obo:IAO_0000115 "ABO phenotype O, corresponding to the genotype OO." ; dc:date "2019-03-03T16:37:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood group O" ; rdfs:subClassOf obo:HP_0032224 . obo:HP_0032443 obo:IAO_0000115 "In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc." ; dc:date "2019-03-03T16:39:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This subontology of the HPO is not intended to provide all needed terms to describe the past medical history, but rather to be combined with other ontologies such as MONDO in order to capture information that is often needed to properly assess phenotypic findings related to a presenting medical problem." ; rdfs:label "Past medical history" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0032444 obo:IAO_0000115 "The affected individual has received an organ transplant previous to the current medical encounter." ; dc:date "2019-03-03T16:49:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "s/p organ transplantation" ; a owl:Class ; rdfs:label "Status post organ transplantation" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0032445 obo:IAO_0000115 "A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid." ; dc:date "2019-03-03T17:31:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lung cyst" ; a owl:Class ; rdfs:comment "The thin wall of cystic lesions differentiates them from cavitary processes, which have thicker and irregular walls and will not be discussed in this article. On chest radiographs, findings of a cyst are often subtle, consisting of lucencies and sometimes linear opacities. An air-fluid level can improve the visibility of a cyst and may suggest infection. For the investigation of cysts, CT is substantially more sensitive than chest radiography, showing a cyst as a ringlike lucency surrounded by a thin wall." ; rdfs:label "Pulmonary cyst" ; rdfs:subClassOf obo:HP_0002088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032446 obo:IAO_0000115 "Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema." ; dc:date "2019-03-03T17:45:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary bullae" ; a owl:Class ; rdfs:comment "Blebs and bullae are commonly subpleural and are mostly seen in both upper lobes in patients with coexisting centrilobular and paraseptal emphysema." ; rdfs:label "Pulmonary bulla" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0032447 obo:IAO_0000115 "A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter. CT findings show a bleb as a thin-walled cystic air space contiguous with the pleura." ; dc:date "2019-03-03T17:47:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary bleb" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0032448 obo:IAO_0000115 "A condition in which production of hydrochloric acid in the stomach is absent." ; dc:date "2019-03-03T17:54:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Gastric acid is the fluid secreted by the stomach. It is composed of hydrochloric acid, potassium chloride, and sodium chloride. Hydrochloric acid plays an integral part in the digestion of food and protects our body against pathogens ingested with food or water. The parietal cells lining the stomach are mainly involved in its production." ; rdfs:label "Achlorhydria" ; rdfs:subClassOf obo:HP_0012719 . obo:HP_0032449 obo:IAO_0000115 "An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane." ; dc:date "2019-03-03T18:24:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hemidesmosomes (HDs) are highly specialized integrin-mediated epithelial attachment structures that make cells firmly adhere to the extracellular matrix by establishing a link between the underlying basement membrane (BM) and the internal mechanical stress-resilient keratin intermediate filament (IF) network. Although HDs are defined by their ultrastructural appearance, two types of HDs, type I and II, can be distinguished on the basis of their protein components. Classical type I HDs, found in stratified and pseudostratified epithelia, for example in the epidermis, consist in five major components, namely integrin alpha6beta4, plectin isoform 1a (P1a), tetraspanin CD151, bullous pemphigoid antigen (BPAG)1 isoform e (BPAG1e, also called BP230) and BPAG2 (also called BP180 or type XVII collagen). Type II HDs, found in simple epithelia such as that of the intestine, consist of integrin alpha6beta4 and plectin and lack the two BP antigens." ; rdfs:label "Abnormal dermoepidermal hemidesmosome morphology" ; rdfs:subClassOf obo:HP_0031538 . obo:HP_0032450 obo:IAO_0000115 "Detection of arsenic in the blood circulation." ; dc:date "2019-03-03T18:42:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive blood arsenic test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0032451 obo:IAO_0000115 "Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented." ; dc:date "2019-03-08T11:02:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Melanotic macule of oral mucosa" ; a owl:Class ; rdfs:comment "Melanotic macules very rarely, if ever, present larger than one centimeter in diameter. Although these are innocuous lesions, a biopsy is usually warranted for diagnosis since mucosal melanoma can mimic the appearance of a melanotic macule. Melanotic macules are caused by functional hyperactivity of the regional melanocytes ie there is increased melanin production. Histologically, this is evidenced by abundant melanin pigmentation within the basal epithelial cell layer with melanin incontinence in the superficial portions of the submucosa. Importantly, there is no increase in melanocyte number. If there is evidence of melanocytic hyperplasia, it should be diagnosed as such and the lesion would likely warrant complete surgical removal. It is possible that melanocytic hyperplasia may potentially herald the development of malignant melanoma." ; rdfs:label "Oral melanotic macule" ; rdfs:subClassOf obo:HP_0100669 . obo:HP_0032452 obo:IAO_0000115 "Oral melanoacanthoma usually presents as an asymptomatic, ill-defined, rapidly enlarging, macular pigmentation. Although most lesions are heavily pigmented, the coloration may or may not be uniform. Any mucosal site may be affected, but buccal mucosal involvement is most common. Although typically solitary, rare patients may present with multifocal lesions." ; dc:date "2019-03-08T11:04:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Oral melanoacanthoma is a relatively uncommon melanocytic lesion that may cause rapid, diffuse, and dark pigmentation of a large mucosal area. However, this is an innocuous pathology that is often self-limiting and may spontaneously resolve, with or without surgical intervention." ; rdfs:label "Oral melanoacanthoma" ; rdfs:subClassOf obo:HP_0100669 . obo:HP_0032453 obo:IAO_0000115 "Abnormal coloring of the lip, whereby the lip discolored, blotchy, or darker or lighter than normal." ; dc:date "2019-03-08T11:06:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lip pigmentation" ; rdfs:subClassOf obo:HP_0000159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032454 obo:IAO_0000115 "Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture." ; dc:date "2019-03-08T11:08:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Labial melanotic freckle" ; a owl:Class ; rdfs:label "Labial melanotic macule" ; rdfs:subClassOf obo:HP_0032453 . obo:HP_0032455 obo:IAO_0000115 "Reduced level of CD18 on the granulocyte surface. This feature can be assessed by flow cytometry." ; dc:date "2019-03-08T11:13:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The beta2 integrin (CD18) expressed on leukocytes can pair with several alpha integrin subunits, and each alpha-beta pairing can bind a variety of ligands, including the counterreceptors ICAM-1, -2 and -3, fibrinogen, the complement fragment iC3b, and polysaccharides." ; rdfs:label "Reduced granulocyte CD18 level" ; rdfs:subClassOf obo:HP_0031553 . obo:HP_0032456 obo:IAO_0000115 "A type of lissencephaly whereby upon neuropathological examination the cortical plate is severely disorganized with a festooned-like pattern and with neither lamination nor clear demarcation between white and grey matter." ; dc:date "2019-03-08T11:17:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unlayered lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0032457 obo:IAO_0000115 "Pachygyria-agyria spectrum whereby at neuropathological examination the cortical plate consists of a two-three layered organization made up of a molecular layer, a relatively thin wavy layer with a higher cellular density and a third layer with lower cellularity." ; dc:date "2019-03-08T11:53:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "2-3-layered lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0032458 obo:IAO_0000115 "A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located." ; dc:date "2019-03-09T17:27:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medullary cavity obliteration", "Narrowing of bone marrow canal", "Narrowing of bone medullary canal", "Narrowing of the marrow cavity" ; a owl:Class ; rdfs:label "Narrowing of medullary canal" ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0032459 obo:IAO_0000115 "Any deviation from the normal level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." ; dc:date "2019-03-09T17:34:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Intracellular availability of the sugar phosphate, 5-phosphoribosyl 1-pyrophosphate (PP-ribose-P), is an important factor in regulation of the rate of purine synthesis de novo. PP-ribose- P synthetase (EC2.7.6.1) is an enzyme that catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate. An increased activity of PP-ribose- P synthetase can be associated with increased PP-ribose-P concentrations and increased purine biosynthetic rates. Increased purine production in turn can be associated with gout." ; rdfs:label "Abnormal phosphoribosylpyrophosphate synthetase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0032460 obo:IAO_0000115 "Abnormally reduced level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." ; dc:date "2019-03-09T17:35:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "It is difficult to assay PRS1 enzyme activity separately from that of the other two isoforms (PRS2 and PRS3), a decrease in PRS enzyme activity may be assumed to reflect decreased activity of PRS1, not PRS2 or PRS3." ; rdfs:label "Decreased phosphoribosylpyrophosphate synthetase level" ; rdfs:subClassOf obo:HP_0032459 . obo:HP_0032461 obo:IAO_0100001 "HP:0045055" ; a owl:Class ; rdfs:label "obsolete Tiger-tail banding" ; owl:deprecated true . obo:HP_0032462 obo:IAO_0000115 "An elevation beyond the normal concentration of palmitate (palmitic acid) in the blood circulation." ; dc:date "2019-03-09T17:54:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Palmitic acid (16:0, PA) is the most common saturated fatty acid found in the human body and can be provided in the diet or synthesized endogenously from other fatty acids, carbohydrates and amino acids. PA represents 20-30% of total fatty acids (FA) in membrane phospholipids, and adipose triacylglycerols (TAG)." ; rdfs:label "Increased circulating palmitate level" ; rdfs:subClassOf obo:HP_0003455 . obo:HP_0032463 obo:IAO_0000115 "A reduction below the normal concentration of fibronectin the the blood circulation." ; dc:date "2019-03-09T18:08:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased plasma fibronectin" ; a owl:Class ; rdfs:comment "Fibronectin is a large vertebrate glycoprotein that is found in soluble and insoluble forms and involved in diverse processes. Protomeric fibronectin is a dimer of subunits, each of which comprises 29-31 modules - 12 type I, two type II and 15-17 type III. Plasma fibronectin is secreted by hepatocytes and circulates in a compact conformation before it binds to cell surfaces, converts to an extended conformation and is assembled into fibronectin fibrils." ; rdfs:label "Reduced circulating fibronectin level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032464 obo:IAO_0000115 "Underdevelopment of the ureter." ; dc:date "2019-04-04T09:26:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoplasia of the ureter", "Ureter hypoplasia" ; a owl:Class ; rdfs:label "Ureteral hypoplasia" ; rdfs:subClassOf obo:HP_0025633 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032465 obo:IAO_0000115 "Muscular projections that protrude into the lumen of the bladder, criss-crossing the walls of the bladder on its inner surface." ; dc:date "2019-04-04T09:28:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trabecular bladder" ; a owl:Class ; rdfs:comment "Bladder trabeculation is caused by morphological and histological changes due to hypertrophy and hyperplasia of the bladder muscle and the infiltration of the connective tissue." ; rdfs:label "Bladder trabeculation" ; rdfs:subClassOf obo:HP_0025487 . obo:HP_0032466 obo:IAO_0000115 "Lack of formation (congenital absence) of the olfactory bulb." ; dc:date "2019-04-04T09:33:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aplastic olfactory bulb", "Olfactory bulb aplasia" ; a owl:Class ; rdfs:comment "Olfactory bulb aplasia causes anosmia, a complete loss of the sense of smell." ; rdfs:label "Aplasia of the olfactory bulb" ; rdfs:subClassOf obo:HP_0040327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032467 obo:IAO_0000115 "Information about past pregnancies including gravidity (number of times a woman has been pregnant, regardless of the outcome), parity (total number of births), gestational age of births, and medical conditions related to past pregnancies." ; dc:date "2019-04-04T09:46:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal medical history" ; a owl:Class ; rdfs:label "Past obstetric history" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0032468 obo:IAO_0000115 "One or more previous pregnancies resulted in stillbirth, defined as death of a fetus in the later stages of pregnancy (definitions in the literature vary, with cut-offs ranging from 20 to 28 weeks gestation)." ; dc:date "2019-04-04T09:53:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "History of stillbirth" ; rdfs:subClassOf obo:HP_0032467 . obo:HP_0032469 obo:IAO_0000115 "Presence of autoantibodies against the asialoglycoprotein receptor (ASGPR) in the blood circulation." ; dc:date "2019-04-09T10:39:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Asialoglycoprotein receptor (ASGPR) is a C-type lectin, primary expressed on the sinusoidal surface of the hepatocyte. ASGPR autoantibodies is considered specific markers of autoimmune hepatitis." ; rdfs:label "Anti-asialoglycoprotein receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032470 obo:IAO_0000115 "The hair shaft has a beaded appearance due to the presence of elliptical nodes that have the diameter of normal hair and are medullated, regularly separated by internodes that are narrow, devoid of medulla and are the site of fracture." ; dc:date "2019-04-09T10:47:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is often accompanied by hair loss." ; rdfs:label "Monilethrix" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0032471 obo:IAO_0000115 "Polymicrogyria affecting one or multiple small areas of the cerebral cortex." ; dc:date "2019-04-09T10:52:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal polymicrogyria" ; rdfs:subClassOf obo:HP_0002126 . obo:HP_0032472 obo:IAO_0000115 "An abnormal concentration of urobilinogen in the urine." ; dc:date "2019-04-09T11:53:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urine urobilinogen level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0032473 obo:IAO_0000115 "An abnormally reduced concentration of urobilinogen in the urine." ; dc:date "2019-04-09T11:54:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Urinary urobilinogen can be reduced or absent if reduced amounts of bilirubin are excreted into the intestinal tract." ; rdfs:label "Decreased urine urobilinogen" ; rdfs:subClassOf obo:HP_0032472 . obo:HP_0032475 dc:date "2019-04-09T12:02:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A malformation of the pachygyria-agyria spectrum. A 6-layered cortex is characterized by bands of ectopic neurons of varying shape and size organized in columns or clusters, lying in a reduced rim of white matter. Layers I and II of the cortex are well defined, and pyramidal and polymorphic neurons of layers III, IV, V, and VI are found more or less in their appropriate location." ; rdfs:label "6-layered lissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0032476 obo:IAO_0000115 "An abnormal concentration of vitamin B6 in the blood circulation." ; dc:date "2019-04-09T12:06:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating vitamin B6 level" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0032477 obo:IAO_0000115 "An abnormally increased concentration of vitamin B6 in the blood circulation." ; dc:date "2019-04-09T12:08:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating vitamin B6 level" ; rdfs:subClassOf obo:HP_0032476 . obo:HP_0032478 obo:IAO_0000115 "Protrusion of the arachnoid and dura through spinal foramina." ; dc:date "2019-04-09T12:13:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lateral spinal meningocele" ; rdfs:subClassOf obo:HP_0002435 . obo:HP_0032479 obo:IAO_0000115 "It is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development." ; dc:date "2019-04-09T12:33:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Preimplantation embryonic lethality" ; a owl:Class ; rdfs:label "Preimplantation lethality" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0032480 obo:IAO_0000115 "An increased amount of beta-aminoisobutyric acid in the urine. Beta-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine." ; dc:date "2019-04-09T12:49:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Beta-aminoisobutyric aciduria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0032481 obo:IAO_0000115 "Any deviation from the normal concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081)." ; dc:date "2019-04-11T11:31:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones." ; rdfs:label "Abnormal pituitary glycoprotein hormone alpha subunit level" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0032482 obo:IAO_0000115 "An reduced concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081)." ; dc:date "2019-04-11T11:33:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased pituitary glycoprotein alpha subunit level", "Decreased pituitary glycoprotein polypeptide alpha subunit level" ; a owl:Class ; rdfs:comment "This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones." ; rdfs:label "Decreased pituitary glycoprotein hormone alpha subunit level" ; rdfs:subClassOf obo:HP_0032481 . obo:HP_0032483 obo:IAO_0100001 "HP:0031685" ; dc:date "2019-04-11T11:37:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal fecal test result" ; owl:deprecated true . obo:HP_0032484 obo:IAO_0000115 "An elevated concentration of sodium in feces." ; dc:date "2019-04-11T11:38:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated faecal sodium" ; a owl:Class ; rdfs:label "Elevated fecal sodium" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0032485 obo:IAO_0000115 "Abnormal concentration of feces as assessed by the total number of solute particles per kilogram." ; dc:date "2019-04-11T11:40:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal faecal osmolality" ; a owl:Class ; rdfs:label "Abnormal fecal osmolality" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0032486 obo:IAO_0000115 "Abnormally high concentration of feces as assessed by the total number of solute particles per kilogram." ; dc:date "2019-04-11T11:41:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated faecal osmolality" ; a owl:Class ; rdfs:label "Elevated fecal osmolality" ; rdfs:subClassOf obo:HP_0032485 . obo:HP_0032487 obo:IAO_0000115 "Abnormally low concentration of feces as assessed by the total number of solute particles per kilogram." ; dc:date "2019-04-11T11:42:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced faecal osmolality" ; a owl:Class ; rdfs:label "Reduced fecal osmolality" ; rdfs:subClassOf obo:HP_0032485 . obo:HP_0032488 obo:IAO_0000115 "Any deviation from the normal pH of feces. The pH reflects the acidity or alkalinity of a solution on a logarithmic scale on which 7 is neutral, whereby lower values are more acid and higher values more alkaline." ; dc:date "2019-04-11T11:44:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal faecal pH" ; a owl:Class ; rdfs:label "Abnormal fecal pH" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0032489 obo:IAO_0000115 "Abnormally high fecal pH, i.e., abnormal alkalinity of feces." ; dc:date "2019-04-11T11:45:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated faecal pH", "Stool pH high" ; a owl:Class ; rdfs:label "Elevated fecal pH" ; rdfs:subClassOf obo:HP_0032488 . obo:HP_0032490 obo:IAO_0000115 "Abnormally low fecal pH, i.e., abnormal acidity of feces." ; dc:date "2019-04-11T11:46:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased faecal pH", "Stool pH low" ; a owl:Class ; rdfs:label "Decreased fecal pH" ; rdfs:subClassOf obo:HP_0032488 . obo:HP_0032491 obo:IAO_0000115 "An increased level of the non-proteinogenic amino acid argininosuccinic acid in the blood circulation." ; dc:date "2019-04-11T12:01:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Argininosuccinic acid is an intermediate in the urea cycle." ; rdfs:label "Increased circulating argininosuccinic acid" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0032492 obo:IAO_0000115 "Presence of antibodies in the serum that react against myelin oligodendrocyte glycoprotein." ; dc:date "2019-04-12T10:32:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-MOG antibody positivity" ; a owl:Class ; rdfs:comment "Myelin oligodendrocyte glycoprotein (MOG), a member of the immunoglobulin (Ig) superfamily, is a myelin protein solely expressed at the outermost surface of myelin sheaths and oligodendrocyte membranes. MOG Abs can be found in a subset of predominantly pediatric patients with acute disseminated encephalomyelitis, aquaporin-4 seronegative neuromyelitis optica spectrum disorders, monophasic or recurrent isolated optic neuritis, or transverse myelitis, in atypical multiple sclerosis, and in N-methyl-d-aspartate receptor-encephalitis." ; rdfs:label "Anti-myelin oligodendrocyte glycoprotein antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0032493 obo:IAO_0000115 "An abnormally high concentration of trypsinogen in the blood circulation." ; dc:date "2019-04-12T10:39:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased immunoreactive trypsinogen" ; a owl:Class ; rdfs:comment "An elevated immunoreactive trypsinogen test can be observed in infants with cystic fibrosis." ; rdfs:label "Increased circulating trypsinogen" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032495 obo:IAO_0000115 "A deviation from the normal proportion of terminal to vellus hairs." ; dc:date "2019-04-12T11:32:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Scalp hairs comprise large terminal hairs and small vellus hairs. Terminal hairs are conspicuous and exceed 0.03 mm in diameter and 1 cm in length, and may be pigmented and medullated. Vellus hairs are inconspicuous and are 0.03 mm or less in diameter and less than 1 cm in length and lack melanin and medulla." ; rdfs:label "Abnormal terminal:vellus ratio" ; rdfs:subClassOf obo:HP_0010720 . obo:HP_0032496 obo:IAO_0000115 "An increased proportion of terminal hairs compared to vellus hairs." ; dc:date "2019-04-12T11:35:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A terminal:vellus ratio over 7:1 is characteristic of chronic telogen effluvium." ; rdfs:label "Elevated terminal:vellus ratio" ; rdfs:subClassOf obo:HP_0032495 . obo:HP_0032497 obo:IAO_0000115 "A terminal:vellus ratio under 4:1 is characteristic of androgenetic alopecia." ; dc:date "2019-04-12T11:38:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An decreased proportion of terminal hairs compared to vellus hairs." ; rdfs:label "Reduced terminal:vellus ratio" ; rdfs:subClassOf obo:HP_0032495 . obo:HP_0032499 obo:IAO_0000115 "The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation." ; dc:date "2019-05-23T22:49:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In Chediak Higashi syndrome, stimulus-induced giant granule mobilization is severely reduced, which may contribute to the propensity for severe bacterial infections." ; rdfs:label "Giant neutrophil granules" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0032500 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by smoking tobacco products." ; dc:date "2019-05-23T22:51:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aggravated by tobacco use", "Exacerbated by smoking", "Smoking or tobacco use exacerbates symptoms" ; a owl:Class ; rdfs:label "Exacerbated by tobacco use" ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0032501 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by taking contraceptive medication." ; dc:date "2019-05-23T22:53:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Contraceptive pills aggravate symptoms" ; a owl:Class ; rdfs:label "Exacerbated by contraceptive medication exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0032502 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by taking barbituates." ; dc:date "2019-05-23T22:55:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Barbiturates produce worsening" ; a owl:Class ; rdfs:label "Exacerbated by barbiturate exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0032503 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by drinking alcohol (ethanol)." ; dc:date "2019-05-23T22:56:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ethanol reduces manifestations" ; a owl:Class ; rdfs:label "Ameliorated by ethanol ingestion" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0032504 obo:IAO_0000115 "An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk." ; dc:date "2019-05-23T22:58:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Barber chair phenomenon", "Lhermitte's phenomenon" ; a owl:Class ; rdfs:comment "Lhermitte's sign is caused by miscommunication between the nerves that have become demyelinated. The pathophysiology of Lhermitte's sign was described as the stretching of the hyper excitable demyelinated dorsal column of the spinal cord, particularly at the cervical level, thus triggering an electric shock-like sensation." ; rdfs:label "Lhermitte's sign" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0032505 obo:IAO_0000115 "Pharyngeal spasms provoked by an attempt to drink." ; dc:date "2019-05-23T23:03:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hydrophobia has been described as a characteristic finding in rabies and can prevent patients from drinking despite intense thirst." ; rdfs:label "Hydrophobia" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0032506 obo:IAO_0000115 "Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb." ; dc:date "2019-05-23T23:05:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Alien limb serves as a diagnostic feature of corticobasal syndrome." ; rdfs:label "Alien limb phenomenon" ; rdfs:subClassOf obo:HP_0004305, obo:HP_0011442 . obo:HP_0032507 obo:IAO_0000115 "Fasciculations affecting the tongue muscle and the musculature of the chin." ; dc:date "2019-05-23T23:07:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fasciculations, labiomental" ; a owl:Class ; rdfs:label "Labiomental fasciculations" ; rdfs:subClassOf obo:HP_0007089 . obo:HP_0032508 obo:IAO_0000115 "Habitual insertion of foreign bodies into bodily orifices." ; dc:date "2019-05-23T23:11:22Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Polyembolokoilamania" ; rdfs:subClassOf obo:HP_5200065 . obo:HP_0032509 obo:IAO_0000115 "Onychotillomania is characterized by the compulsive or irresistible urge in patients to pick at, pull off, or harmfully bite or chew their nails." ; dc:date "2019-05-23T23:17:34Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:comment "Onychotillomania is not to be confused with onychophagia which is self-induced damage to nails caused by nail biting." ; rdfs:label "Onychotillomania" ; rdfs:subClassOf obo:HP_5200065 . obo:HP_0032510 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon." ; dc:date "2019-05-23T23:19:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tendon pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0032511 obo:IAO_0000115 "The position of the umbilicus (belly button) is abnormally high (superior)." ; dc:date "2019-05-23T23:22:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superiorly positioned umbilicus" ; rdfs:subClassOf obo:HP_0001551 . obo:HP_0032513 obo:IAO_0000115 "Four-vessel umbilical cord containing two arteries and two veins." ; dc:date "2019-05-23T23:25:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A normal umbilical cord contains two umbilical arteries and one umbilical vein." ; rdfs:label "Four-vessel umbilical cord" ; rdfs:subClassOf obo:HP_0011403 . obo:HP_0032514 obo:IAO_0000115 "A congenital developmental anomaly characterized by the presence of two (instead of the normal one) lacrimal punctum on one or both sides of the face." ; dc:date "2019-05-23T23:34:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Double lacrimal puncta", "Lacrimal punctum, duplication" ; a owl:Class ; rdfs:label "Duplicated lacrimal punctum" ; rdfs:subClassOf obo:HP_0011479 . obo:HP_0032515 obo:IAO_0000115 "A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements." ; dc:date "2019-05-26T10:20:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Deep dermatophytosis is is found primarily in immunocompromised patients with chronic dermatophytosis. This form of invasive disease may result from follicular rupture with direct cutaneous invasion, sometimes augmented by trauma or topical corticosteroid creams. It is not necessarily associated with hair follicles and tends to be more rapid in onset, larger, and extend deeper than Majocchi's granuloma. These infections can form clusters of granulomas, pseudomycetomas, lymphedema and draining sinuses." ; rdfs:label "Deep dermatophytosis" ; rdfs:subClassOf obo:HP_0032516 . obo:HP_0032516 obo:IAO_0000115 "Infection that extends deeply into the dermis by dermatophytes, fungi that typically cause different types of superficial infection (tinea) or skin, hair, or nails." ; dc:date "2019-05-26T10:24:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The most common presentation of dermatophytosis in clinical practice is the appearance of scaly, cutaneous lesions found on the trunk in tinea coporis (ringworm), the feet or toes in tinea pedis (athlete's foot), the crural fold in tinea cruris (jock itch), the scalp in tinea capitis (cradle cap), or a discoloration of the fingernails or toenails in tinea unguium (onychomycosis). Dermatophytosis is a typically noninvasive infection but can evolve into a more aggressive disease in the immunocompromised host." ; rdfs:label "Invasive dermatophyte infection" ; rdfs:subClassOf obo:HP_0032162 . obo:HP_0032517 obo:IAO_0000115 "Majocchi's granuloma (MG) is an inflammatory and granulomatous, dermatophytic infection characterized by a granulomatous inflammation around the hair follicle. Histopathologically, MG demonstrates a nodular perifollicular granulomatous infiltrate of lymphoid cells, macrophages, epithelioid cells, multinucleated giant cells, and neutrophils. Unlike superficial dermatophytoses, fungal hyphae and spores can be detected not only on the surface of the epidermis but also within or around the hair follicles." ; dc:date "2019-05-26T10:32:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Majocchi's granuloma (MG) is classified into two forms, depending on the affected individual's health situation and clinical picture. The first form is mainly observed in healthy individuals and is defined as a perifollicular, papular form induced by penetrating trauma that is mostly observed in the lower extremities. The second form is granulomatous, related to immunosuppression, seen in a nodular form, and usually appears on the upper extremities. The main cause of MG is Trichophyton rubrum, followed by T. mentagrophytes, T. violaceum, and T. tonsurans. However, several fungi, such as T. interdigitale, Microsporum canis, Nannizzia gypsea (former M. gypseum), Epidermophyton floccosum, and Aspergillus species, can also cause MG." ; rdfs:label "Majocchi's granuloma" ; rdfs:subClassOf obo:HP_0032516 . obo:HP_0032518 obo:IAO_0000115 "A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs." ; dc:date "2019-05-26T10:37:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Disseminated dermatophytosis tends to occur in patients with both defi cient T cell-mediated immunity and an impaired infl ammatory response. This process occurs either by direct extension, draining lymphatics, or hematogenous spread. It can present with involvement of distant skin areas, lymph nodes, bone, muscle, liver, spleen, testes or the central nervous system. Ultimately, disseminated infection can result in bacterial superinfection, osteomyelitis, organ dysfunction and eventual death." ; rdfs:label "Disseminated dermatophytosis" ; rdfs:subClassOf obo:HP_0032516 . obo:HP_0032519 obo:IAO_0000115 "Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals." ; dc:date "2019-05-26T11:08:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased Burr cell count" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0032520 obo:IAO_0000115 "Reduced strength of the masseter muscle, whose primary function is to elevate the mandible and thereby raise the mandible towards the maxilla, closing the jaw." ; dc:date "2019-05-26T11:14:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Masseter muscular weakness" ; rdfs:subClassOf obo:HP_0031815 . obo:HP_0032521 obo:IAO_0000115 "Involuntary, tic-like movements consisted of crossing both arms across the chest and tensing the body or clasping the hands and squeezing the arms to the sides. The movements last a few seconds and may occur in series or flurries, generally accompanied by facial grimacing and occasional grunting." ; dc:date "2019-05-26T11:19:58Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Spasmodic upper-body squeeze" ; a owl:Class ; rdfs:comment "This is a characteristic behavior in Smith-Magenis syndrome." ; rdfs:label "Self hugging" ; rdfs:subClassOf obo:HP_4000079, obo:HP_5200019 . obo:HP_0032522 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with immunosuppresive medication." ; dc:date "2019-05-26T11:24:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Immunosupressive therapy improves condition" ; a owl:Class ; rdfs:label "Ameliorated by immunosuppresion" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0032523 obo:IAO_0000115 "An abnormal increase in the thickness (diameter) of a tendon." ; dc:date "2019-05-26T11:35:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tendon thickening" ; rdfs:subClassOf obo:HP_0100261 . obo:HP_0032524 obo:IAO_0000115 "Length of the thumb is greater than normal." ; dc:date "2019-05-26T11:38:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Long thumb" ; rdfs:subClassOf obo:HP_0001172 . obo:HP_0032525 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by treatment with an acetylcholinesterase inhibitor such as tensilon (edrophonium) or pyridostigmine (Mestinon)." ; dc:date "2019-05-26T11:44:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by acetylcholinesterase inhibitor exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0032526 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by an acetylcholinesterase inhibitor such as mestinon or tensilon." ; dc:date "2019-05-26T11:47:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by acetylcholinesterase inhibitor" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0032527 obo:IAO_0000115 "The position of the umbilicus (belly button) is abnormally low (inferior)." ; dc:date "2019-05-26T11:50:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low set umbilicus", "Low-set umbilicus" ; a owl:Class ; rdfs:label "Inferiorly positioned umbilicus" ; rdfs:subClassOf obo:HP_0001551 . obo:HP_0032528 obo:IAO_0000115 "An increased amount of 4-hydroxybutyric acid in the urine." ; dc:date "2019-05-27T12:47:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group." ; rdfs:label "Elevated urinary 4-hydroxybutyric acid" ; rdfs:subClassOf obo:HP_0033303 . obo:HP_0032529 obo:IAO_0100001 "HP:0410053" ; dc:date "2019-05-27T12:51:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Elevated circulating gamma-aminobutyric acid concentration" ; owl:deprecated true . obo:HP_0032530 obo:IAO_0000115 "Reduced level of succinic semialdehyde dehydrogenase (SSADH)." ; dc:date "2019-05-27T12:55:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Succinic semialdehyde dehydrogenase catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)." ; rdfs:label "Decreased succinic semialdehyde dehydrogenase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0032531 dc:date "2019-05-27T12:58:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gamma-aminobutyric acid (GABA) high in CSF" ; a owl:Class ; rdfs:comment "Abnormally increased level of gamma-amino butyric acid (GABA) in the cerebrospinal fluid (CSF)." ; rdfs:label "Elevated CSF gamma-aminobutyric acid concentration" ; rdfs:subClassOf obo:HP_0500183 . obo:HP_0032532 obo:IAO_0000115 "Abnormally increased level of 4-hydroxybutyric acid in the cerebrospinal fluid (CSF)." ; dc:date "2019-05-27T13:00:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF GHB levels", "Elevated CSF gamma-hydroxybutyric acid" ; a owl:Class ; rdfs:label "Elevated CSF 4-hydroxybutyric acid concentration" ; rdfs:subClassOf obo:HP_0500183 . obo:HP_0032533 obo:IAO_0000115 "An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies." ; dc:date "2019-05-27T13:06:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating acetone concentration" ; rdfs:subClassOf obo:HP_0410175 . obo:HP_0032534 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by ingestion of food containing a methylxanthine compound (for instance, coffee, caffeine, chocolate)." ; dc:date "2019-05-27T13:08:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Methylxanthines produce worsening" ; a owl:Class ; rdfs:label "Exacerbated by methylxanthine ingestion" ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0032535 obo:IAO_0000115 "Applies to an abnormality that is situated in the neck." ; dc:date "2019-05-27T13:12:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cervical (neck)" ; rdfs:subClassOf obo:HP_0012838 . obo:HP_0032536 obo:IAO_0000115 "An abnormally elevated number of lymph nodes in an anatomical region." ; dc:date "2019-05-27T13:15:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "For example, lymphedema-distichiasis syndrome is characterized by an increased number of lymphatic vessels and inguinal lymph nodes." ; rdfs:label "Increased number of lymph nodes" ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0032537 obo:IAO_0000115 "A delay in healing of a fracture past the expected duration." ; dc:date "2019-05-27T13:23:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Initially, after injury a hematoma forms and this is followed by inflammatory cells arriving at the fracture site to debride the wound. During the soft callus phase of healing a collar of bone forms at the periosteum adjacent to the fractured bone, and cells in the periosteum proliferate and differentiate into chondrocytes that form cartilage that bridges the fracture gap. During the hard callus phase, the cartilage is replaced by bone through endochondral ossification, possibly by transformation of some of the chondrocytes into osteoblasts. Finally, through remodeling, newly formed bone is restored to its pre-injured state. Depending on the site of the fracture, healing usually takes from 3 to 12 weeks in healthy adults." ; rdfs:label "Delayed fracture healing" ; rdfs:subClassOf obo:HP_0011843 . obo:HP_0032538 obo:IAO_0000115 "A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lenghten as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg." ; dc:date "2019-05-27T13:33:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pretibial dimple" ; rdfs:subClassOf obo:HP_0010781 . obo:HP_0032539 obo:IAO_0000115 "Applies to an abnormality that is situated in extensor surface of the joint. The extensor surface refers to the skin on the opposite side of a joint." ; dc:date "2019-05-27T13:48:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Joint extensor surface localization" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0032540 obo:IAO_0000115 "Applies to an abnormality that is situated in flexor surface of the joint. The flexor surface refers to the skin that touches when a joint is bent (flexed)." ; dc:date "2019-05-27T13:51:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Joint flexor surface localization" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0032541 obo:IAO_0000115 "Knuckle pads are benign fibrofatty subcutaneous pads located over the proximal interphalangeal (PIP) joints that can be mistaken for arthritis. Rarely they affect the dorsal aspect of the metacarpophalangeal (MCP) joints. Clinically they are painless and often affect both hands in an asymmetrical pattern." ; dc:date "2019-05-27T15:11:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Knuckle pads on dorsal aspect of finger joints" ; a owl:Class ; rdfs:comment "Knuckle pads can be associated with camptodactyly (fixed flexion deformity of the interphalangeal joints of the little finger) as overlapping symptoms and are associated with many genetic factors. Although they can be associated to repetitive local trauma (for example repetitive batting of the knuckles, e.g. by boxers or suction the fingers by children), coexist with palmar (Dupuytren disease) or plantar fibromatosis (Ledderhose disease) or Peyronie disease, most knuckle pads are idiopathic." ; rdfs:label "Knuckle pad" ; rdfs:subClassOf obo:HP_0011356 . obo:HP_0032542 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by being pregnant." ; dc:date "2019-05-27T15:16:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by pregnancy" ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0032543 obo:IAO_0000115 "Expectoration (coughing up) of a broncholith. Broncholithiasis is defined as the presence of calculi in the tracheobronchial tree. It is a rare disease but can be characterized by clinical and radiological findings of a calcified lymph node eroding bronchial wall and opening into the bronchial lumen." ; dc:date "2019-05-27T15:19:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lithoptysis" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0032544 obo:IAO_0000115 "Applies to an abnormality that mainly affects the small joints, including fingers, toes, interphalangeal, metacarpophalangeal, metatarsophalangeal, wrists, ankles, vertebrae, and neck." ; dc:date "2019-06-12T10:19:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Predominant small joint localization" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0032545 obo:IAO_0000115 "Involuntary tightening of the abdominal musculature that occurs in response to touching the abdomen to avoid pain. Rigidity can occur in the presence of abdominal inflammation and usually involves only the inflamed area." ; dc:date "2019-06-12T10:23:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Rigid abdomen" ; a owl:Class ; rdfs:label "Abdominal rigidity" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0032546 obo:IAO_0000115 "A voluntary contraction of the abdominal wall musculature to avoid pain." ; dc:date "2019-06-12T10:33:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Abdominal guarding tends to be generalized over the entire abdomen. In contrast to abdominal rigidity, guarding can often be overcome by having the patient purposely relax the muscles; rigidity cannot be." ; rdfs:label "Abdominal guarding" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0032547 obo:IAO_0000115 "An abnormal decrease of the pressure within the eye." ; dc:date "2019-06-12T10:37:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ocular hypotony" ; a owl:Class ; rdfs:comment "Ocular hypotony is defined statistically as an intraocular pressure (IOP) of less than 6.5 mmHg, three standard deviations below the mean. Clinically significant hypotony is when the IOP is so low that there is resultant visual loss. Hypotony has also been described as low pressure in an individual eye, leading to functional changes and structural changes." ; rdfs:label "Low intraocular pressure" ; rdfs:subClassOf obo:HP_0012632 . obo:HP_0032548 obo:IAO_0000115 "Abnormally elevated placental thickness." ; dc:date "2019-06-12T10:49:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Placental thickness increased" ; a owl:Class ; rdfs:comment "Placental thickness can be measured ultrasonographically at the thickest portion of the placenta or beneath the cord insertion, and in a representative portion perpendicular to the chorionic plate. The ultrasonographic measurement of placental thickness is a simple method to estimate placental size, and a thick placenta may be a useful predictor of adverse pregnancy outcomes." ; rdfs:label "Increased placental thickness" ; rdfs:subClassOf obo:HP_0012767 . obo:HP_0032549 obo:IAO_0000115 "Persistence beyond the normal age (roughly the first half of the first year of life) of the asymmetric tonic neck reflex (ATNR), which is an easily elicited primitive reflex in the immediate newborn period. The ATNR refers to the phenomenon whereby when the face of an infant is turned to one side, the ipsilateral arm and leg extend and the contralateral arm and leg flex. This posture has been compared to a typical posture of fencers." ; dc:date "2019-06-12T10:56:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Persistent fencer's reflex", "Tonic neck reflex asymmetrical and persistent" ; a owl:Class ; rdfs:label "Persistent asymmetrical tonic neck reflex" ; rdfs:subClassOf obo:HP_0002476 . obo:HP_0032550 obo:IAO_0000115 "Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets." ; dc:date "2019-06-14T10:19:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Purple spheres, usually about 0.5 micrometers in diameter, presenting singly, or rarely multiply, in the cytoplasm of red blood cells." ; rdfs:label "Howell-Jolly bodies" ; rdfs:subClassOf obo:HP_0020080 . obo:HP_0032551 obo:IAO_0000115 "Enlarged, bulging blood vessels in and around the anus often associated with rectal bleeding, itching, and pain." ; dc:date "2019-06-14T10:37:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Haemorrhoids", "Piles" ; a owl:Class ; rdfs:comment "Hemorrrhoids result from dilation of the submucosal vascular tissue in the distal anal canal. This vascular tissue is supported by connective tissue that, when weakened, leads to descent or prolapse of the hemorrhoids. Internal hemorrhoids originate above the dentate line (i.e., the junction between columnar and squamous epithelium) and are viscerally innervated and, therefore, painless. External hemorrhoids originate below the dentate line, have somatic innervation, and can cause pain. Some patients have both internal and external (mixed) hemorrhoids." ; rdfs:label "Hemorrhoids" ; rdfs:subClassOf obo:HP_0002034 . obo:HP_0032552 obo:IAO_0000115 "An anomaly of the rhythmic throbbing of an artery that reflects the widening of the artery as blood flows through it and is caused by successive contractions of the heart." ; dc:date "2019-06-14T10:43:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulse" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0032553 obo:IAO_0000115 "A diminution in the amplitude (strength) of the pulse such that the examiner has difficulty feeling the pulse." ; dc:date "2019-06-14T10:47:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Weak pulse" ; rdfs:subClassOf obo:HP_0032552 . obo:HP_0032554 obo:IAO_0000115 "The pulsation of an artery where the pulse is taken (e.g. the radial artery at the wrist) cannot be detected on physical examination." ; dc:date "2019-06-14T10:48:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent pulse" ; rdfs:subClassOf obo:HP_0032552 . obo:HP_0032555 obo:IAO_0000115 "Increased amplitude (strength) of the pulse." ; dc:date "2019-06-14T10:50:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bounding pulse" ; rdfs:subClassOf obo:HP_0032552 . obo:HP_0032556 obo:IAO_0000115 "Persistent blue color of the skin that surrounds the mouth." ; dc:date "2019-06-14T10:53:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bluish around mouth" ; a owl:Class ; rdfs:comment "Circumoral cyanosis may be a sign of peripheral or of central cyanosis." ; rdfs:label "Circumoral cyanosis" ; rdfs:subClassOf obo:HP_0034031 . obo:HP_0032557 obo:IAO_0000115 "A past medical history of hematopoietic stem cell transplantation involving myeloablative chemoradiotherapy followed by stem cell rescue with autologous or human leukocyte antigen (HLA)-matched stem cells derived from a donor." ; dc:date "2019-06-14T11:13:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Status post haematopoietic stem cell transplantation", "Status post hematopoietic stem cell transplantation" ; a owl:Class ; rdfs:label "History of bone marrow transplant" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0032558 obo:IAO_0000115 "Sperm cells lacking flagella." ; dc:date "2019-06-15T00:17:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1B from PMID:30867909." ; rdfs:label "Absent sperm flagella" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0032559 obo:IAO_0000115 "Sperm cells with abnormally short flagella." ; dc:date "2019-06-15T00:21:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1B of PMID:30867909." ; rdfs:label "Short sperm flagella" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0032560 obo:IAO_0000115 "Sperm cells whose flagella are twisted (coiled)." ; dc:date "2019-06-15T00:22:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Coiled sperm flagella" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0032561 obo:IAO_0000115 "Decreased size of the head of sperm." ; dc:date "2019-06-15T00:25:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Small-head sperm" ; a owl:Class ; rdfs:label "Microcephalic sperm head" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0032562 obo:IAO_0000115 "Sperm with cigar-shaped heads that gradually dimish in diameter (taper)." ; dc:date "2019-06-15T00:28:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tapered sperm head" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0032563 obo:IAO_0000115 "Presence of teardrop-shaped red blood cells." ; dc:date "2019-06-15T00:47:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dacryocytes", "Tear-drop shaped erythrocytes" ; a owl:Class ; rdfs:label "Dacryocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0032564 obo:IAO_0000115 "Inflammation of the ileum." ; dc:date "2019-06-19T10:14:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inflammation of the ileum" ; a owl:Class ; rdfs:comment "Ileitis may present acutely with right lower quadrant pain and/or diarrhea, or with chronic obstructive symptoms and bleeding." ; rdfs:label "Ileitis" ; rdfs:subClassOf obo:HP_0001549 . obo:HP_0032565 dc:date "2019-06-19T10:17:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A breach of the continuity of the mucous membrane of the vagina caused by sloughing out of inflamed necrotic tissue, usually associated with eschars (slough or piece of dead tissue) and with violaceous to erythematous borders." ; rdfs:label "Vaginal mucosal ulceration" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0032566 obo:IAO_0000115 "Enlarged, oval-shaped erythrocytes (red blood cells)." ; dc:date "2019-06-19T10:24:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:19202968." ; rdfs:label "Oval macrocytosis" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0032567 obo:IAO_0000115 "An increased lipid content in the urine." ; dc:date "2019-06-19T10:35:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Urinary lipid excretion" ; a owl:Class ; rdfs:label "Lipiduria" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0032568 obo:IAO_0000115 "Distal tubular epithelial cells in which globotriaosylceramide (Gb3) has accumulated. they are the characteristic feature of Fabry disease. Urinary mulberry bodies are a component of mulberry cells that can be distinguished easily from fat particles by their inner lamellar appearance." ; dc:date "2019-06-19T10:42:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:28593486." ; rdfs:label "Urinary mulberry cells" ; rdfs:subClassOf obo:HP_0012614 . obo:HP_0032569 obo:IAO_0000115 "Prominence (bulging) in the temple region, which is the part of the skull where the frontal, parietal, temporal, and sphenoid bones join on the side of the head." ; dc:date "2019-06-19T10:48:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Temporal bossing" ; rdfs:subClassOf obo:HP_0009911 . obo:HP_0032570 obo:IAO_0000115 "Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons." ; dcterms:creator ; oboInOwl:hasExactSynonym "Pontine ischaemic lacunes" ; a owl:Class ; rdfs:label "Pontine ischemic lacunes" ; rdfs:subClassOf obo:HP_0007361, obo:HP_0032325 . obo:HP_0032571 obo:IAO_0000115 "An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased oocyte death" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0032572 obo:IAO_0000115 "A deviation from the normal level of a nucleobase in the urine. Nucleobases are nitrogen-containing biological compounds that form nucleosides: adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U)." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary nucleobase concentration" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18282 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032573 obo:IAO_0000115 "Increased levels of urinary cytidine, a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1 glycosidic bond." ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary cytidine" ; rdfs:subClassOf obo:HP_0033162 . obo:HP_0032574 obo:IAO_0000115 "Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated uridine in urine" ; a owl:Class ; rdfs:label "Elevated urinary uridine level" ; rdfs:subClassOf obo:HP_0033162 . obo:HP_0032575 obo:IAO_0000115 "A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating 12-Hydroxyeicosatetraenoic acid concentration" ; a owl:Class ; rdfs:label "Decreased circulating 12-HETE" ; rdfs:subClassOf obo:HP_0011022 . obo:HP_0032576 obo:IAO_0000115 "Intracellular accumulation of the lipid-linked oligosaccharide intermediate Man5GlcNAc2-PP-dolichol." ; dcterms:creator ; a owl:Class ; rdfs:comment "Intracellular accumulation of Dol-PP-GlcNAc2Man5 can result from a defect in ALG3, which encodes a mannosyltransferase that transfers mannose from dolichyl phosphate mannose. The accumulation can be measured in fibroblasts. During protein N-glycosylation, glycans from lipid-linked oligosaccharides (LLOs) are transferred onto asparagine residues located in N-glycosylation sequons. The synthesis of LLO comprises three steps: It begins with the biosynthesis of the intermediate Dol-PP-GlcNAc2Man5, which occurs on the cytoplasmic side of the endoplasmic reticulum (ER). The second step is the flipping of this intermediate to the luminal side of the ER. The third step comprises the glycan extension in the ER lumen, yielding Dol-PP-GlcNAc2Man9." ; rdfs:label "Intracellular accumulation of Dol-PP-GlcNAc2Man5" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0032577 obo:IAO_0000115 "Presence of a predominant T cell clone. In PCR-based assays, this finding is inferred on the basis of one or two prominent bands within a valid size range. In NGS-based assays, this finding is inferred on the basis of a high number of reads that map to a single T cell receptor clone." ; dcterms:creator ; a owl:Class ; rdfs:label "Clonal T cell receptor rearrangement" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0032578 obo:IAO_0000115 "An epithelial lined cyst filled with gelatinous material. The gelatinous material commonly contains mucin, old blood, cholesterol, and ions. Most colloid cysts identified are currently asymptomatic and identified incidentally on imaging. When a colloid cyst does cause issues, it most commonly causes obstructive hydrocephalus." ; dcterms:creator ; a owl:Class ; rdfs:comment "The colloid cyst is most commonly found in the rostral third ventricle at or near the foramen of Monro. The foramen of Monro is the conduit of cerebrospinal fluid (CSF) outflow from the lateral ventricles to the third ventricle. A colloid cyst can act as a ball valve, stopping CSF flow out of the lateral ventricles. If this occurs, CSF backs up into the lateral ventricles and causes ventriculomegaly and hydrocephalus." ; rdfs:label "Third ventricle colloid cyst" ; rdfs:subClassOf obo:HP_0010576, obo:HP_0010951 . obo:HP_0032579 obo:IAO_0000115 "A benign focal growth composed of vascular tissue." ; dcterms:creator ; a owl:Class ; rdfs:label "Vascular hamartoma" ; rdfs:subClassOf obo:HP_0010566 . obo:HP_0032580 obo:IAO_0000115 "Abnormal structure of the bulbus cordis, which is the single outflow tract of the heart during early embryogenesis." ; dcterms:creator ; a owl:Class ; rdfs:comment "The portion of the embryonic heart that receives blood is called the sinus venosus. There are two horns, the left and the right, that pump blood into the primordial atrium, which is then pumped into the ventricle and the bulbus cordis. From the bulbus cordis, it goes into the aortic sac which is connected to the first aortic arch." ; rdfs:label "Abnormal bulbus cordis morphology" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_0032581 obo:IAO_0000115 "Any structural anomaly of the interstitium of the kidney. The renal interstitium is defined as the intertubular, extraglomerular, extravascular space of the kidney. It is bounded on all sides by tubular and vascular basement membranes and is filled with cells, extracellular matrix, and interstitial fluid." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal insterstitial morphology" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0032582 obo:IAO_0000115 "Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles." ; dcterms:creator ; a owl:Class ; rdfs:comment "FCs are the outcome of cellular lipid accumulation due to lipid metabolic dysfunction. Normally, lipid is in a dynamic equilibrium outside and inside of the cell. When factors facilitate cell lipid intake or reduce its efflux, it subsequently resulted in cellular lipid accumulation and FC formation. Renal interstitial FCs are commonly encountered in Alport syndrome and are occasionally observed in various other kidney diseases, including idiopathic membranous nephropathy (IMN), IgA nephropathy (IgAN), focal and segmental glomerulosclerosis (FSGS), and membranoproliferative glomerulonephritis." ; rdfs:label "Renal interstitial foam cells" ; rdfs:subClassOf obo:HP_0003651, obo:HP_0032581 . obo:HP_0032583 dcterms:creator ; a owl:Class ; rdfs:comment "Accumulation of foam cells (FC) in glomeruli of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles." ; rdfs:label "Renal glomerular foam cells" ; rdfs:subClassOf obo:HP_0000095, obo:HP_0003651 . obo:HP_0032584 obo:IAO_0000115 "Increased numbers of neutrophils in the interstitial tissues of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial neutrophil infiltration" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032585 obo:IAO_0000115 "Increased numbers of eosinophils in the interstitial tissues of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial eosinophil infiltration" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032586 obo:IAO_0000115 "Increased numbers of plasma cells in the interstitial tissues of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial plasma cell infiltration" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032587 obo:IAO_0000115 "The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial calcium oxalate" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032588 obo:IAO_0000115 "Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects." ; dcterms:creator ; oboInOwl:hasExactSynonym "Lack of purposeful hand use" ; a owl:Class ; rdfs:label "Hand apraxia" ; rdfs:subClassOf obo:HP_0002186 . obo:HP_0032589 obo:IAO_0000115 "Infiltration of the renal tubular epithelium by lymphocytes." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal lymphocytic tubulitis" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032590 obo:IAO_0000115 "Infiltration of the renal tubular epithelium by neutrophils." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal neutrophilic tubulitis" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032591 obo:IAO_0000115 "Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:comment "Hemosiderin is an iron-containing, golden-brown, granular pigment derived from ferritin, the initial iron-storage protein. As iron accumulates within the cell, aggregates of ferritin molecules form hemosiderin. Upon hemolysis of red blood cells, hemoglobin alpha-beta dimers are released that, if unbound to haptoglobin, are filtered by the glomerulus and appear in the urine as hemoglobinuria. The hemoglobin dimers are taken up by renal proximal tubular cells and degraded and the free chelatable iron is stored as hemosiderin in the lysosomes. Hemosiderin deposition in kidney tubular cells has been reported in different types of hemolytic anemia including autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria and sickle cell anemia and after cardiac valve replacement with residual valvular regurgitation or perivalvular leak." ; rdfs:label "Renal interstitial hemosiderin" ; rdfs:subClassOf obo:HP_0032644 . obo:HP_0032592 obo:IAO_0000115 "Congenital absence of the right-sided diaphragm." ; dcterms:creator ; oboInOwl:hasExactSynonym "Right diaphragmatic hernia" ; a owl:Class ; rdfs:label "Aplasia of the right hemidiaphragm" ; rdfs:subClassOf obo:HP_0000776, obo:HP_0040047 . obo:HP_0032593 obo:IAO_0000115 "A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented." ; dcterms:creator ; a owl:Class ; rdfs:label "Myoglobin casts" ; rdfs:subClassOf obo:HP_0031199 . obo:HP_0032594 obo:IAO_0000115 "Naked basement membranes without tubular epithelium." ; dcterms:creator ; oboInOwl:hasExactSynonym "Denuded tubular basement membrane" ; a owl:Class ; rdfs:label "Renal tubular basement membrane denudation" ; rdfs:subClassOf obo:HP_0020131 . obo:HP_0032595 obo:IAO_0000115 "Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell detachment" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032596 obo:IAO_0000115 "Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell cytoplasmic vacuolization" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032597 obo:IAO_0000115 "At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell sloughing" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032598 obo:IAO_0000115 "Tubular cross section with round/irregular cytoplasmic protrusion, shaped like the Greek capital letter Omega (or it may be more vertically elongated Omega), pinched off from apical membrane without apparent closure of the lumen, involving over 50 percent of the tubular cells in cross section. The feature can be further classified into proximal or distal tubule." ; dcterms:creator ; a owl:Class ; rdfs:label "Blebbing of apical cytoplasm of renal tubular epithelial cells" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032599 obo:IAO_0000115 "Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal tubular epithelial morphology" ; rdfs:subClassOf obo:HP_0000091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032600 obo:IAO_0000115 "Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell hyaline droplets" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032601 obo:IAO_0000115 "Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view." ; dcterms:creator ; a owl:Class ; rdfs:label "Multinucleation of renal tubular epithelial cells" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032602 obo:IAO_0000115 "Tubular epithelium with nucleoli clearly visible at 100-fold magnification." ; dcterms:creator ; a owl:Class ; rdfs:label "Prominent nucleoli of renal tubular epithelial cells" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032603 obo:IAO_0000115 "Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell simplification" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032604 obo:IAO_0000115 "Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell mitosis" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032605 obo:IAO_0000115 "At least one tubular epithelial cell with average sized cytoplasmic area and a nuclear area 3 times greater than average sized nuclei." ; dcterms:creator ; oboInOwl:hasExactSynonym "High N/C ratio of renal tubular epithelial cells" ; a owl:Class ; rdfs:label "High renal tubular epithelial cell N/C ratio" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032606 obo:IAO_0000115 "Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial lipofuscin" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032607 obo:IAO_0000115 "Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell swelling" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032608 obo:IAO_0000115 "A type of renal tubular atrophy characterized by a thyroid-like appearance, with small round tubules with markedly flattened, simplified epithelium and uniform intratubular casts." ; dcterms:creator ; a owl:Class ; rdfs:label "Thyroidization-type tubular atrophy" ; rdfs:subClassOf obo:HP_0000092 . obo:HP_0032609 obo:IAO_0000115 "A type of renal tubular atrophy characterized by endocrine-like appearance of tubules, which are small and have narrow lumina, clear cells, and relatively thin basement membranes." ; dcterms:creator ; oboInOwl:hasExactSynonym "Endocrinization pattern of tubular atrophy", "Renal tubular atrophy, endocrine-type" ; a owl:Class ; rdfs:label "Endocrine-type tubular atrophy" ; rdfs:subClassOf obo:HP_0000092 . obo:HP_0032610 obo:IAO_0000115 "Renal tubulointerstitial infiltration of mycobacteria identified on acid-fast or Fite stains. Can be associated with granulomatous inflammation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal tubulointerstitial mycobacterial organisms" ; a owl:Class ; rdfs:label "Tubulointerstitial mycobacterial infiltration" ; rdfs:subClassOf obo:HP_0032635 . obo:HP_0032611 obo:IAO_0000115 "Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment." ; dcterms:creator ; a owl:Class ; rdfs:comment "Renal tubular epithelial cells process reabsorbed urinary hemoglobin to hemosiderin." ; rdfs:label "Renal tubular epithelial cell hemosiderin" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032612 obo:IAO_0000115 "A hallux (big toe) with three phalanges in a single, proximo-distal axis." ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be seen in Figure 1c of PMID:22486404." ; rdfs:label "Triphalangeal hallux" ; rdfs:subClassOf obo:HP_0010057 . obo:HP_0032613 obo:IAO_0000115 "Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial amyloid", "Renal interstitial amyloid deposition", "Renal interstitial amyloidosis" ; a owl:Class ; rdfs:label "Renal interstitial amyloid deposits" ; rdfs:subClassOf obo:HP_0001917, obo:HP_0032644 . obo:HP_0032614 obo:IAO_0000115 "Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal glomerular amyloid deposition" ; rdfs:subClassOf obo:HP_0001917 . obo:HP_0032615 obo:IAO_0000115 "A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images." ; dcterms:creator ; oboInOwl:hasExactSynonym "Diffusion weighted imaging (DWI) abnormality", "Diffusion weighted magnetic resonance imaging (DWI) abnormality", "MRI diffusion abnormality of the cerebrum" ; a owl:Class ; rdfs:label "Abnormal diffusion weighted cerebral MRI morphology" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0032616 obo:IAO_0000115 "Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial immunoglobulin deposition" ; a owl:Class ; rdfs:comment "Monoclonal immunoglobulin deposition is characterized by nonorganized electron-dense granular deposits predominantly localized in basement membranes of the kidney (other organs may additionally be affected). By light microscopy, tubular lesions are characterized by the deposition of a refractile, eosinophilic, periodic acid-Schiff (PAS)-positive, ribbon-like material along the tubular basement membrane. immunofluorescence examination of the kidney. Immunofluoerescence may show evidence of monotypic light or heavy chain fixation along tubular basement membranes. Electron microscopy can show finely to coarsely granular electron-dense deposits along the outer (interstitial) aspect of the tubular basement membranes." ; rdfs:label "Renal interstitial immunoglobulin deposits" ; rdfs:subClassOf obo:HP_0032644 . obo:HP_0032617 obo:IAO_0000115 "A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial haemorrhage" ; a owl:Class ; rdfs:label "Renal interstitial hemorrhage" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032618 obo:IAO_0000115 "Cell death (necrosis) affecting one or more parts of the kidney." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal parenchymal necrosis" ; a owl:Class ; rdfs:label "Renal necrosis" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032619 obo:IAO_0000115 "A perinephric abscess is a collection of suppurative material in the perinephric space (i.e., the connective and adipose tissues surrounding the kidney)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Detecting its presence can be diagnostically challenging because, in its chronic form, it usually develops insidiously, and in some cases its appearance can even simulate a renal tumor. The presence of a perinephric collection of purulent material around the kidneys occurs more often insidiously as a secondary phenomenon to upper tract urosepsis, classically in association with an infective staghorn renal calculus." ; rdfs:label "Perinephric abscess" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0032620 obo:IAO_0000115 "An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal abscess", "Renal parenchymal abcess" ; a owl:Class ; rdfs:comment "Most renal abscesses are caused by gram-negative bacteria and are commonly caused by ascending infection associated with urologic abnormality, obstruction or calculi." ; rdfs:label "Intrarenal abscess" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032621 obo:IAO_0000115 "At least one tubular cross section with all tubular epithelial nuclei having a chromatin pattern resembling normal mature lymphocytes." ; dcterms:creator ; oboInOwl:hasExactSynonym "Condensed chromatin of renal tubular epithelial cells" ; a owl:Class ; rdfs:label "Hyperchromasia of renal tubular epithelial cells" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032622 obo:IAO_0000115 "Dilatation (expansion beyond the normal dimension) of the cavity (lumen) of tubules of the kidney. The tubular cross section displays an attenuated brush border (apical PAS positivity greater than 10 percent of the normal expected height, but unequivocally less than normal expected height), resulting in an apparent increase in the size of lumen." ; dcterms:creator ; oboInOwl:hasExactSynonym "Tubular ectasia" ; a owl:Class ; rdfs:comment "By definition, ,tubular luminal dilatation excludes simplifcation, which is defined as a tubular cross-section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush borderinvolving over 50 percent of the tubular cells in cross-section, resulting in an apparent increase in the size of lumen, without presence of casts." ; rdfs:label "Tubular luminal dilatation" ; rdfs:subClassOf obo:HP_0032950 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001571 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009773 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032623 obo:IAO_0000115 "Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast." ; dcterms:creator ; oboInOwl:hasExactSynonym "Tubular casts" ; a owl:Class ; rdfs:comment "Casts can be subsequently eliminated via the urine and may be seen by microscopy of the urine sediment, which should be coded separately using an appropriate term from the Cylindruria subhierarchy (HP:0012615). Intratubular casts may have various compositions with different morphologic and staining characteristics. Both hyaline and granular casts may be observed in a number of renal diseases. Commonly observed casts are hyaline (eosinophilic, homogeneous proteinaceous) casts associated with increased glomerular permeability such as with chronic progressive nephropathy and granular (necrotic cellular debris) casts." ; rdfs:label "Renal intratubular casts" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032624 obo:IAO_0000115 "A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green)." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular bilirubin casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032625 obo:IAO_0000115 "Casts that contain red blood cells and are located within the tubuli of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular erythrocyte cast" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032626 obo:IAO_0000115 "Intratubular casts composed of vancomycin aggregates and uromodulin." ; dcterms:creator ; a owl:Class ; rdfs:comment "The casts appear as nonspecific proteinaceous casts within the tubular lumenss on light microscopy. Immunostaining can be used to confirm the presence of vancomycin." ; rdfs:label "Intratubular vancomycin casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032627 obo:IAO_0000115 "Casts that contain white blood cells and are located within the tubuli of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular leukocyte casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032628 dcterms:creator ; a owl:Class ; rdfs:label "Renal intratubular crystals" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032629 obo:IAO_0000115 "Intratubular crystals composed of 2,8-dihydroxyadenine are small needle-shaped brownish crystals that are highly birefringent under polarized light and black by Jones methenamine silver." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular dihydroxyadenuria crystals" ; rdfs:subClassOf obo:HP_0032628 . obo:HP_0032630 obo:IAO_0000115 "The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules." ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be ascertained by (i) Light microscopy: The biopsy shows chronic tubulointerstitial nephritis with fractured casts that first involve the distal tubules. The casts have a metachromatic appearance due to their mixed composition of light chain (Bence-Jones) and Tamm-Horsfall (uromodulin) proteins. Surrounding cellular reaction can extend to formation of syncytial giant cells, and in the early phase may be a polymorphonuclear granulocyte reaction. (ii) Immunofluorescence microscopy: Monoclonal staining of casts for either kappa or lambda light chains confirm the diagnosis, but clonal staining may be absent in some cases. Staining of formalin-fixed paraffin-embedded material after pronase digestion may unmask clonal staining in some of these cases. (iii) Electron microscopy: Glomeruli are unremarkable, and casts show granular electron-dense material. Crystalline substructure may be seen within these light chain casts. In rare cases, deposits of amyloid may form on the surface of the casts." ; rdfs:label "Intratubular light-chain casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032631 obo:IAO_0000115 "A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. On H&E (red granular), PAS (purple), trichrome (red granular), Hall (yellow brown). Stain positively for Hemoglobin A." ; dcterms:creator ; oboInOwl:hasExactSynonym "Intratubular haemoglobin casts" ; a owl:Class ; rdfs:label "Intratubular hemoglobin casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032632 obo:IAO_0000115 "Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal papillary necrosis" ; rdfs:subClassOf obo:HP_0032618 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000647 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0032633 obo:IAO_0000115 "A type of acellular urinary cast located within the distal tubules of the kidney and that is composed only of Tamm-Horsfall glycoprotein. Correspondingly, these casts have a low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends." ; dcterms:creator ; oboInOwl:hasExactSynonym "Intratubular Tamm-Horsfall (uromodulin) casts" ; a owl:Class ; rdfs:label "Intratubular hyaline casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032634 obo:IAO_0000115 "Casts located within the tubuli of the kidney and that contain myoglobin. Myoglobin casts are composed of round granules that may line up in chains or aggregate in clusters. Their color ranges from pink to red-brown with hematoxylin and eosin stain, light brown to black with Jones methenamine silver stain, pink to bright magenta with periodic acid-Schiff stain, and bright red with trichrome stain. Immunoperoxidase staining with antibody to myoglobin is stronglypositive in the casts.Electron microscopy shows globular casts with an electron-dense core and a somewhat less-intense periphery. Substructure is absent. This feature may be accompanied by acute tubular injury with variable flattening of tubular epithelial cells, loss of brush borders, and intratubular sloughed epithelial cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular myoglobin cast" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032635 obo:IAO_0000115 "Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain." ; dcterms:creator ; a owl:Class ; rdfs:label "Tubulointerstitial microganismal infiltration" ; rdfs:subClassOf obo:HP_0001969 . obo:HP_0032636 obo:IAO_0000115 "Infiltration of viruses into renal tubulointerstitial tissues as demonstrated on renal biopsy by viral inclusions which can be seen on routine stains or with immunohistochemistry." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal tubulointerstitial viral inclusions" ; a owl:Class ; rdfs:label "Tubulointerstitial viral infiltration" ; rdfs:subClassOf obo:HP_0001969 . obo:HP_0032637 obo:IAO_0000115 "Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial oedema" ; a owl:Class ; rdfs:label "Renal interstitial edema" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032638 obo:IAO_0000115 "An abnormally increased amount of mevanolate in the urine. Mevanolate is that hydroxy monocarboxylic acid anion that is the conjugate base of mevalonic acid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urine mevalonate", "Elevated urine mevalonate levels", "Elevated urine mevalonic acid", "Mevalonate aciduria" ; a owl:Class ; rdfs:label "Elevated urine mevalonic acid level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0032639 obo:IAO_0000115 "An increased concentration of cystine within white blood cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated leukocyte cystine" ; rdfs:subClassOf obo:HP_0003358 . obo:HP_0032640 obo:IAO_0000115 "An increased concentration of C-C motif chemokine ligand 18 in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased C-C motif chemokine ligand 18 concentration" ; a owl:Class ; rdfs:label "Elevated circulating CCL18 level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032641 obo:IAO_0000115 "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial granulomata" ; a owl:Class ; rdfs:label "Renal interstitial granulomas" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032642 obo:IAO_0000115 "An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial necrotizing granulomata" ; a owl:Class ; rdfs:comment "Granulomatous inflammation is a distinctive form of chronic inflammation produced in response to various infectious, autoimmune, toxic, allergic, and neoplastic conditions." ; rdfs:label "Renal interstitial necrotizing granulomas" ; rdfs:subClassOf obo:HP_0032641 . obo:HP_0032643 obo:IAO_0000115 "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal interstitial non-necrotizing granulomata" ; a owl:Class ; rdfs:label "Renal interstitial non-necrotizing granulomas" ; rdfs:subClassOf obo:HP_0032641 . obo:HP_0032644 obo:IAO_0000115 "Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial deposits" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032645 obo:IAO_0000115 "Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei)." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial mononuclear cell infiltration" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032646 obo:IAO_0000115 "Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial xanthogranulomatous inflammation" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032647 obo:IAO_0000115 "Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular epithelial cell apoptosis" ; rdfs:subClassOf obo:HP_0032599 . obo:HP_0032648 obo:IAO_0000115 "The presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus." ; dcterms:creator ; a owl:Class ; rdfs:label "Tubularization of Bowman capsule" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0032649 obo:IAO_0000115 "A type of flat-foot characterized by hindfoot abductovalgus, metatarsus adductus, and Achilles tendon shortening. The predominant radiographic findings include forefoot adduction with lateral subluxation of the navicular on the talus and heel valgus. Very abnormal shoe wear is noted on the medial side. Calluses occurunder the metatarsal heads and thehead of the plantar-flexed talus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Skew foot", "Skew-foot" ; a owl:Class ; rdfs:comment "Operative indications include pain, intractable calluses, and shoe and orthotic problems." ; rdfs:label "Skewfoot" ; rdfs:subClassOf obo:HP_0001763 . obo:HP_0032650 obo:IAO_0000115 "Increased concentration of glial fibrillary acidic protein in cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF glial fibrillary acidic protein level" ; a owl:Class ; rdfs:comment "Elevated CSF glial fibrillary acidic protein levels are considered to be a glial marker of neuroinflammation." ; rdfs:label "Elevated CSF glial fibrillary acidic protein concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0032651 obo:IAO_0000115 "Increased concentration of chitinase-3-like protein 1 in cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF chitinase-3-like protein 1 level" ; a owl:Class ; rdfs:label "Elevated CSF chitinase-3-like protein 1 concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0032652 obo:IAO_0000115 "Increased concentration of chitotriosidase 1 in cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF chitotriosidase 1 level" ; a owl:Class ; rdfs:label "Elevated CSF chitotriosidase 1 concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0032653 obo:IAO_0000115 "An abnormal increase in the molar ratio of lactate to pyruvate in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:comment "The lactate:pyruvate (L:P) ratio reflects the equilibrium between the product and substrate of the reaction catalyzed by lactase dehydrogenase and indirectly reflects the NADH:NAD+ cytoplasmic redox state. When cellular respiration or mitochondrial oxidative metabolism is impaired, such as in inborn errors of components of the mitochondrial respiratory chain, there is an increase in reducing equivalents (excess NADH and absence of NAD+) which results in an elevated L:P molar ratio." ; rdfs:label "Elevated lactate:pyruvate ratio" ; rdfs:subClassOf obo:HP_0004360 . obo:HP_0032654 obo:IAO_0000115 "Flow-mediated dilatation is a noninvasive tests of endothelial function that leverages ultrasound to measure arterial diameter and its response to an increase in shear stress, which normally causes endothelium-dependent dilatation. This term pertains to an abnormal reduction in the magnitude of dilatation. Flow-mediated dilatation is usually measured at the brachial artery." ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Endothelial dysfunction" ; a owl:Class ; rdfs:comment "The diameter of the target artery is measured by high-resolution external vascular ultrasound in response to an increase in blood flow (causing shear-stress) during reactive hyperaemia (induced by cuff inflation and then deflation). This leads to endothelium-dependent dilatation; the response is contrasted with that to sublingual nitroglycerin, an endothelium-independent dilator. The artery is scanned and the diameter measured during three conditions; at baseline, during reactive hyperaemia (induced by inflation and then deflation of a sphygmomanometer cuff around the limb, distal to the scanned part of the artery) and finally after administration of sublingual nitroglycerin using a normal antianginal dose of 400 microgram (which causes endothelium-independent smooth muscle mediated vasodilatation)." ; rdfs:label "Impaired flow-mediated arterial dilatation" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0032655 obo:IAO_0000115 "A reduced concentration of tocopherol in fat tissue." ; dcterms:creator ; a owl:Class ; rdfs:comment "Tocopherols, the major forms of vitamin E, are a group of fat soluble phenolic compounds. About 90 percent of the total body content of tocopherol is found in adipose tissue. Therefore, vitamin E in adipose tissue (AT) has been proposed as a potential indicator of long-term intake of vitamin E." ; rdfs:label "Decreased adipose tissue tocopherol level" ; rdfs:subClassOf obo:HP_0032243 . obo:HP_0032656 obo:IAO_0000115 "A seizure lasting 30 minutes without fully regaining consciousness, provoked by fever (temperature greater than 38.0 degrees Celcius) at the time of seizure-onset, without a prior history of afebrile seizure and with no evidence of an acute central nervous system infection or insult." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fever-induced status epilepticus" ; a owl:Class ; rdfs:comment "Some but not all cases of Febrile Infection-related Epilepsy Syndrome (FIRES) may meet this definition; however, in many cases of FIRES the individual will no longer be febrile at the time of the seizure onset." ; rdfs:label "Febrile status epilepticus" ; rdfs:subClassOf obo:HP_0002133, obo:HP_0011172 . obo:HP_0032657 obo:IAO_0000115 "An abnormal increase in the level of globotriaosylsphingosine (Lyso-Gb3) in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Fabry disease is an X-linked lysosomal storage disease caused by deficiency of alpha-galactosidase A that affects males and shows disease expression in heterozygotes. Lysosomal accumulation of its substrate globotriaosylceramide (Gb3) that is prominent in endothelial cells is thought to cause the progressive renal insufficiency, cardiac involvement, and CNS pathology in Fabry patients. Plasma Lyso-Gb3 is considered to be a biomarker for Fabry disease." ; rdfs:label "Elevated circulating lyso-globotriaosylsphingosine concentration" ; rdfs:subClassOf obo:HP_0003119 . obo:HP_0032658 obo:IAO_0000115 "Status epilepticus with prominent motor signs during the prolonged seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Status epilepticus with prominent motor symptoms" ; rdfs:subClassOf obo:HP_0002133 . obo:HP_0032659 obo:IAO_0000115 "A type of status epilepticus without prominent motor symptoms and in the presence of coma." ; dcterms:creator ; oboInOwl:hasExactSynonym "Subtle status epilepticus" ; a owl:Class ; rdfs:comment "This includes the entity subtle status epilepticus proposed by some authors as the late, burned-out stage of generalized convulsive status epilepticus characterized by (subtle rather than predominant) focal or multifocal myoclonic movements, coma, and pseudoperiodic epileptiform discharges against a slow low-voltage background on EEG." ; rdfs:label "Non-convulsive status epilepticus with coma" ; rdfs:subClassOf obo:HP_0031475 . obo:HP_0032660 obo:IAO_0000115 """A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between. comment: source: seeAlso: Tonic-clonic status epilepticus""" ; dcterms:creator ; oboInOwl:hasExactSynonym "Tonic-clonic status epilepticus" ; a owl:Class ; rdfs:comment "In 2015, the ILAE Task Force on Classification of Status Epilepticus did proposed that time t1 (indicating the time that emergency treatment should be started because the seizure is unlikely to terminate spontaneously) is 5 minutes and t2 (the time at which long-term consequences of the seizure may be expected) is 30 minutes for convulsive (tonic-clonic) status epilepticus.This 5-minute timeframe has been endorsed by the 2012 Neurocritical Care Society Guidelines and the 2016 American Epilepsy Society Guidelines to guide when emergent treatment for convulsive status epilepticus should start. This term includes convulsive status epilepticus of focal, generalized or unknown onset." ; rdfs:label "Convulsive status epilepticus" ; rdfs:subClassOf obo:HP_0002069, obo:HP_0032658 . obo:HP_0032661 obo:IAO_0000115 "A type of bilateral convulsive seizure of generalized onset that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Generalised convulsive status epilepticus" ; a owl:Class ; rdfs:label "Generalized convulsive status epilepticus" ; rdfs:subClassOf obo:HP_0025190, obo:HP_0032660 . obo:HP_0032662 obo:IAO_0000115 "A type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal onset seizure evolving into bilateral convulsive status epilepticus", "Focal-onset seizure evolving into generalised convulsive status epilepticus", "Focal-onset seizure evolving into generalized convulsive status epilepticus", "Partial onset seizure evolving into convulsive status epilepticus", "Partial-onset seizure evolving into convulsive status epilepticus", "Secondarily generalised convulsive status epilepticus", "Secondarily generalised tonic-clonic status epilepticus", "Secondarily generalized convulsive status epilepticus", "Secondarily generalized tonic-clonic status epilepticus" ; a owl:Class ; rdfs:label "Focal-onset seizure evolving into bilateral convulsive status epilepticus" ; rdfs:subClassOf obo:HP_0007334, obo:HP_0032660 . obo:HP_0032663 obo:IAO_0000115 "Status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." ; dcterms:creator ; a owl:Class ; rdfs:comment "Including aware and unaware focal motor status epilepticus, but note that hyperkinetic status epilepticus (of focal onset) is classified separately." ; rdfs:label "Focal motor status epilepticus" ; rdfs:subClassOf obo:HP_0032658 . obo:HP_0032664 obo:IAO_0000115 "A type of focal motor status epilepticus characterized by continuous neck or body rotation and conjugate gaze deviation in a direction contralateral to the responsible epileptic focus. This includes some forms of tonic status epilepticus." ; dcterms:creator ; a owl:Class ; rdfs:label "Adversive status epilepticus" ; rdfs:subClassOf obo:HP_0032663 . obo:HP_0032665 obo:IAO_0000115 "A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Jacksonian status epilepticus" ; a owl:Class ; rdfs:label "Repeated focal motor seizures" ; rdfs:subClassOf obo:HP_0032663 . obo:HP_0032666 obo:IAO_0000115 "Status epilepticus characterized by continuous hyperkinetic proximal limb or axial muscles producing irregular sequential ballistic movements such as pedaling pelvic thrusting, thrashing, or rocking movements." ; dcterms:creator ; a owl:Class ; rdfs:comment "In 2015 the ILAE classified hyperkinetic status epilepticus separately from focal motor status epilepticus characterized by elemental motor features. Awareness may be intact or impaired." ; rdfs:label "Hyperkinetic status epilepticus" ; rdfs:subClassOf obo:HP_0032658 . obo:HP_0032667 obo:IAO_0000115 "A type of motor status epilepticus with repeating bilateral sudden brief (less than 100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography." ; dcterms:creator ; a owl:Class ; rdfs:comment "The myoclonic seizures are usually generalized. The duration or frequency of myoclonic jerks required to qualify as myoclonic status is not defined, but they should occur frequently and long enough to significantly impair functioning. A reasonable general definition might be that myoclonus must occur either (1) at least once every 10 seconds for longer than 10 minutes or (2) at least once a minute for longer than 30 minutes." ; rdfs:label "Myoclonic status epilepticus" ; rdfs:subClassOf obo:HP_0032658 . obo:HP_0032668 obo:IAO_0000115 "A type of myoclonic status epilepticus in the absence of coma." ; dcterms:creator ; a owl:Class ; rdfs:label "Myoclonic status epilepticus without coma" ; rdfs:subClassOf obo:HP_0032667 . obo:HP_0032669 obo:IAO_0000115 "A type of myoclonic status epilepticus in the presence of coma." ; dcterms:creator ; a owl:Class ; rdfs:label "Myoclonic status epilepticus with coma" ; rdfs:subClassOf obo:HP_0032667 . obo:HP_0032670 obo:IAO_0000115 "Tonic status epilepticus is a type of status epilepticus characterized by focal or bilateral limb stiffening or elevation, which may be electrographically generalized or focal." ; dcterms:creator ; a owl:Class ; rdfs:comment "This has most commonly been reported in children with neurocognitive impairment and severe epilepsy, such as Ohtahara syndrome or West syndrome and Lennox-Gastaut syndrome. The tonic activity can be a sustained abnormal posture, either in extension or flexion, sometimes accompanied by tremor of the extremities." ; rdfs:label "Tonic status epilepticus" ; rdfs:subClassOf obo:HP_0032658 . obo:HP_0032671 obo:IAO_0000115 "A type of status epilepticus without prominent motor symptoms in the absence of coma." ; dcterms:creator ; a owl:Class ; rdfs:label "Non-convulsive status epilepticus without coma" ; rdfs:subClassOf obo:HP_0031475 . obo:HP_0032672 obo:IAO_0000115 "Autonomic status epilepticus is a type of non-convulsive status epilepticus without coma with prominent autonomic features regardless of whether it is electrographically generalized or focal." ; dcterms:creator ; a owl:Class ; rdfs:comment "Autonomic disturbances may include tachycardia, cardiac arrhythmia, hypertension, high fever, salivation, vomiting and incontinence." ; rdfs:label "Autonomic status epilepticus" ; rdfs:subClassOf obo:HP_0032671 . obo:HP_0032673 obo:IAO_0000115 "Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure." ; dcterms:creator ; a owl:Class ; rdfs:comment "Semiology may include autonomic, sensory, visual, olfactory, gustatory, emotional/psychic/experiential, or cognitive symptoms. Consciousness or awareness may be intact or impaired." ; rdfs:label "Focal non-convulsive status epilepticus without coma" ; rdfs:subClassOf obo:HP_0032671 . obo:HP_0032674 obo:IAO_0000115 "A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occured owing to an injury of the skin. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time." ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin wound" ; a owl:Class ; rdfs:label "Cutaneous wound" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0032675 obo:IAO_0000115 "A cutaneous wound that is proceeding through an orderly and timely reparative process that results in sustained restoration of the anatomic and functional integrity of the skin." ; dcterms:creator ; a owl:Class ; rdfs:comment """Wound healing accors in multiple overlapping stages, with re=-eipthelialization normally beginning on day one or two. In most clinical settings, closure of acute and chronic wounds is considered the wound healing end point, but wounds can continue to undergo remodeling or tissue maturation for several months or even years.""" ; rdfs:label "Acute cutaneous wound" ; rdfs:subClassOf obo:HP_0032674 . obo:HP_0032676 obo:IAO_0000115 "A cutaneous wound that has failed to proceed through the orderly and timely process to produce an atomic and functional integrity, or proceeded through the repair process without establishing a sustained anatomic and functional result." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic nonhealing cutaneous wound" ; a owl:Class ; rdfs:label "Chronic cutaneous wound" ; rdfs:subClassOf obo:HP_0032674 . obo:HP_0032677 obo:IAO_0000115 "A generalized motor seizure is a type of generalized-onset seizure with predominantly motor (involving musculature) signs. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." ; dcterms:creator ; oboInOwl:hasExactSynonym "Generalised onset motor seizure", "Generalised-onset motor seizure", "Generalized onset motor seizure" ; a owl:Class ; rdfs:label "Generalized-onset motor seizure" ; rdfs:subClassOf obo:HP_0002197, obo:HP_0020219 . obo:HP_0032678 obo:IAO_0000115 "An eyelid myoclonia seizure is a type of generalized myoclonic seizure which may or may not be associated with loss of awareness." ; dcterms:creator ; a owl:Class ; rdfs:label "Eyelid myoclonia seizure" ; rdfs:subClassOf obo:HP_0002123 . obo:HP_0032679 obo:IAO_0000115 "A type of focal-onset seizure characterized by non-motor signs or symptoms (or behaviour arrest) as its initial semiological manifestation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal seizure without motor onset", "Partial seizure without motor onset" ; a owl:Class ; rdfs:comment "Non-motor terms correspond to the earliest prominent sign or symptom." ; rdfs:label "Focal non-motor seizure" ; rdfs:subClassOf obo:HP_0007359, obo:HP_0033259 . obo:HP_0032680 obo:IAO_0000115 "A focal cognitive seizure involves an alteration in a cognitive function (which can be a deficit or a positive phenomenon such as forced thought), which occurs at seizure onset. To be classified as a focal cognitive seizure, the change in cognitive function should be specific and out of proportion to other relatively unimpaired aspects of cognition, because all cognition is impaired in a focal impaired awareness seizure." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0011162" ; oboInOwl:hasExactSynonym "Cognitive aura", "Cognitive seizure", "Partial cognitive seizure" ; a owl:Class ; rdfs:comment "In order to characterize focal cognitive seizures, specific testing may be required early during the seizure." ; rdfs:label "Focal cognitive seizure" ; rdfs:subClassOf obo:HP_0032679 . obo:HP_0032681 obo:IAO_0000115 "A focal aware cognitive seizure during which awareness is retained throughout the seizure." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032683", "HP:0032881" ; a owl:Class ; rdfs:label "Focal aware cognitive seizure" ; rdfs:subClassOf obo:HP_0032680, obo:HP_0032682 . obo:HP_0032682 obo:IAO_0000115 "A focal non-motor seizure in which awareness is retained throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal non-motor aware seizure" ; a owl:Class ; rdfs:label "Focal aware non-motor seizure" ; rdfs:subClassOf obo:HP_0002349, obo:HP_0032679 . obo:HP_0032683 obo:IAO_0100001 "HP:0032681" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Focal aware cognitive seizure with impaired attention" ; owl:deprecated true . obo:HP_0032684 obo:IAO_0000115 "A focal cognitive seizure with auditory agnosia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with auditory agnosia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032685 . obo:HP_0032685 obo:IAO_0000115 "A focal cognitive seizure characterized by auditory agnosia as the initial semiological manifestation. For example a person may hear a ringing sound, but may not connect this with the concept that the sound is from a telephone ringing." ; dcterms:creator ; a owl:Class ; rdfs:comment "Auditory agnosia is the inability to recognize or differentiate between sounds / words or to relate them to their meaning despite being able to hear them." ; rdfs:label "Focal cognitive seizure with auditory agnosia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032686 obo:IAO_0000115 "A focal cognitive seizure with memory impairment characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with memory impairment" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032687 . obo:HP_0032687 obo:IAO_0000115 "A focal cognitive seizure characterized by transient memory impairment as the initial semiological manifestation whilst other cognitive functions and awareness are preserved at seizure onset. The memory impairment may be an inability to recall events occurring prior to the seizure (retrograde amnesia), or failure to encode new memories for events occurring during the seizure (anterograde amnesia)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Amnestic aura", "Amnestic seizure" ; a owl:Class ; rdfs:comment "www.epilepsydiagnosis.org focuses on anterograde amnesia during the seizure. Both ictal retrograde and anterograde amnesia have been included here given that they are well studied as ictal manifestations of 'transient epileptic amnesia'. The clinical onset of these seizures is defined by questions indicating ictal retrograde amnesia, often because of disorientation. Ictal anterograde amnesia is incomplete in many individuals with transient epileptic amnesia: half at least partly recall 'not being able to remember' during seizures." ; rdfs:label "Focal cognitive seizure with memory impairment" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032688 obo:IAO_0000115 "A focal cognitive seizure with dissociation characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with dissociation" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032689 . obo:HP_0032689 obo:IAO_0000115 "A focal cognitive seizure characterized by an experience of being disconnected from, though aware of, self or environment as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal cognitive seizure with dissociation" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032690 obo:IAO_0000115 "A focal cognitive seizure with dyscalculia and or acalculia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with dyscalculia/acalculia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032691 . obo:HP_0032691 obo:IAO_0000115 "A focal cognitive seizure characterized by dyscalculia / acalculia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Dyscalculia / acalculia is difficulty completing or understanding mathematical calculation. This seizure type is seen in seizures involving the dominant hemisphere parieto-temporal lobe region." ; rdfs:label "Focal cognitive seizure with dyscalculia/acalculia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032692 obo:IAO_0000115 "A focal cognitive seizure characterized by forced thinking as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Forced thinking is the presence of intrusive thoughts, ideas or crowding of thoughts. This is a rare seizure type, seen in mesial parietal, posterior parahippocampal and frontal lobe seizures." ; rdfs:label "Focal cognitive seizure with forced thinking" ; rdfs:subClassOf obo:HP_0032680, obo:HP_0033347 . obo:HP_0032693 obo:IAO_0000115 "A focal cognitive seizure characterized by neglect as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Neglect is unilateral failure to report or respond to stimuli presented contralaterally." ; rdfs:label "Focal cognitive seizure with neglect" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032694 obo:IAO_0000115 "A focal cognitive seizure characterized by dyslexia / alexia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Dyslexia / alexia is the inability to read due to an impairment in understanding written words rather than visual impairment. This seizure type is seen in seizures involving the dominant hemisphere parieto-temporal lobe region." ; rdfs:label "Focal cognitive seizure with dyslexia/alexia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032695 obo:IAO_0100001 "HP:0012008" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Illusory auras" ; owl:deprecated true . obo:HP_0032696 obo:IAO_0000115 "A focal cognitive seizure characterized by receptive dysphasia / aphasia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "This seizure type is seen in seizures involving the dominant hemisphere parieto-temporal lobe region." ; rdfs:label "Focal cognitive seizure with receptive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032697 obo:IAO_0000115 "A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation." ; obo:IAO_0100001 "HP:0012004" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Focal cognitive seizure with deja vu/jamais vu" ; owl:deprecated true . obo:HP_0032698 obo:IAO_0000115 "A focal cognitive seizure characterized by conduction dysphasia / aphasia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Conduction dysphasia / aphasia is the inability to repeat speech that is heard, due to failure to encode phonological information, in the setting of intact auditory comprehension (full understanding of what is heard), and fluent speech production (subject to paraphrasic errors)." ; rdfs:label "Focal cognitive seizure with conduction dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032699 obo:IAO_0000115 "A focal cognitive seizure characterized by dysgraphia / agraphia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Dysgraphia / agraphia is difficulty in writing. This seizure type is seen in seizures involving the dominant hemisphere parieto-temporal lobe region." ; rdfs:label "Focal cognitive seizure with dysgraphia/agraphia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032700 obo:IAO_0000115 "A focal cognitive seizure characterized by left-right confusion as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Left-right confusion is the inability to distinguish right from left. This seizure type is seen in seizures involving the dominant hemisphere parieto-temporal lobe region." ; rdfs:label "Focal cognitive seizure with left-right confusion" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032701 obo:IAO_0000115 "A focal cognitive seizure characterized by anomia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Anomia is the inability to name objects despite knowing what they are." ; rdfs:label "Focal cognitive seizure with anomia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032702 obo:IAO_0000115 "A focal cognitive seizure characterized by expressive dysphasia / aphasia as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Expressive dysphasia / aphasia is the inability to express one's thoughts despite being aware of what they wished to say because of a disorder of language rather than articulation." ; rdfs:label "Focal cognitive seizure with expressive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032680 . obo:HP_0032703 obo:IAO_0100001 "HP:0012007" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Hallucinatory aura" ; owl:deprecated true . obo:HP_0032704 obo:IAO_0000115 "A focal cognitive seizure with illusion characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with illusion" ; rdfs:subClassOf obo:HP_0012008, obo:HP_0032681 . obo:HP_0032705 obo:IAO_0000115 "A focal cognitive seizure with forced thinking characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with forced thinking" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032692 . obo:HP_0032706 obo:IAO_0000115 "A focal cognitive seizure with left-right confusion characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with left-right confusion" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032700 . obo:HP_0032707 obo:IAO_0000115 "A focal cognitive seizure with dyslexia / alexia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with dyslexia/alexia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032694 . obo:HP_0032708 obo:IAO_0000115 "A focal cognitive seizure with anomia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with anomia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032701 . obo:HP_0032709 obo:IAO_0000115 "A focal cognitive seizure with dysgraphia / agraphia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with dysgraphia/agraphia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032699 . obo:HP_0032710 obo:IAO_0000115 "A focal cognitive seizure with receptive dysphasia / aphasia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with receptive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032696 . obo:HP_0032711 obo:IAO_0000115 "A type of focal clonic seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware clonic seizure" ; rdfs:subClassOf obo:HP_0002266, obo:HP_0020217 . obo:HP_0032712 obo:IAO_0000115 "A type of focal motor seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure" ; a owl:Class ; rdfs:label "Focal impaired awareness motor seizure" ; rdfs:subClassOf obo:HP_0002384, obo:HP_0011153 . obo:HP_0032713 obo:IAO_0000115 "A focal motor seizure with version characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure with version" ; a owl:Class ; rdfs:comment "Version id defined as sustained, forced, involuntary turning of the eyes or head." ; rdfs:label "Focal impaired awareness motor seizure with version" ; rdfs:subClassOf obo:HP_0011175, obo:HP_0032712 . obo:HP_0032714 obo:IAO_0000115 "A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness bilateral motor seizure" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032715 . obo:HP_0032715 obo:IAO_0000115 "A type of focal motor seizure (it commences in one hemisphere) involving bilateral muscle groups rapidly at seizure onset." ; dcterms:creator ; a owl:Class ; rdfs:comment "Not to be confused with a focal to bilateral tonic-clonic seizure (to which it may progress). Certain frontal lobe seizure sub-types have bilateral motor features at onset, often with asymmetric posturing. Typically, there is extension of the upper limb (at the elbow) contralateral to the hemisphere of seizure onset (often with a clenched fist and flexion at the wrist) and flexion of the ipsilateral upper limb at the elbow. This type of seizure is also described as a 'fencer's posture' or a 'figure of 4'." ; rdfs:label "Focal bilateral motor seizure" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032716 obo:IAO_0000115 "A focal non-motor seizure characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal non-motor impaired awareness seizure" ; a owl:Class ; rdfs:label "Focal impaired awareness non-motor seizure" ; rdfs:subClassOf obo:HP_0002384, obo:HP_0032679 . obo:HP_0032717 obo:IAO_0000115 "A focal motor seizure with dystonia characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure with dystonia" ; a owl:Class ; rdfs:label "Focal impaired awareness motor seizure with dystonia" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032718 . obo:HP_0032718 obo:IAO_0000115 "A focal motor seizure in which the initial semiological manifestation is the sustained contraction of both agonist and antagonist muscles producing athetoid or twisting movements, which produces abnormal postures." ; dcterms:creator ; a owl:Class ; rdfs:comment "The abnormal movements of dystonia resulting from co-contraction of agonist and antagonist muscles differentiates these from tonic seizures, see focal tonic seizure." ; rdfs:label "Focal motor seizure with dystonia" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032719 obo:IAO_0000115 "A focal motor seizure with dysarthria / anarthria characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure with dysarthria/anarthria" ; a owl:Class ; rdfs:label "Focal impaired awareness motor seizure with dysarthria/anarthria" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032720 . obo:HP_0032720 obo:IAO_0000115 "A type of focal motor seizure characterized by difficulty with articulation of speech, due to impaired coordination of muscles involved in speech sound production as the initial semiological manifestation. Receptive and expressive language functions are intact, however speech is poorly articulated and is less intelligible." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal motor seizure with dysarthria/anarthria" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032721 obo:IAO_0000115 "A focal motor seizure characterized by weakness or complete paralysis of a muscle or group of muscles as the initial semiological manifestation." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal motor seizure with paresis/paralysis" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032722 obo:IAO_0000115 "A type of focal tonic seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware tonic seizure" ; rdfs:subClassOf obo:HP_0011167, obo:HP_0020217 . obo:HP_0032723 obo:IAO_0000115 "A focal motor seizure with dystonia characterized by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor aware seizure with dystonia" ; a owl:Class ; rdfs:label "Focal aware motor seizure with dystonia" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032718 . obo:HP_0032724 obo:IAO_0000115 "A focal tonic seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness tonic seizure" ; rdfs:subClassOf obo:HP_0011167, obo:HP_0032712 . obo:HP_0032725 obo:IAO_0000115 "A type of focal clonic seizure during which awareness is partially or fully impaired at some point in the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness clonic seizure" ; rdfs:subClassOf obo:HP_0002266, obo:HP_0032712 . obo:HP_0032726 obo:IAO_0000115 "A focal hyperkinetic seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness hyperkinetic seizure" ; rdfs:subClassOf obo:HP_0011174, obo:HP_0032712 . obo:HP_0032727 obo:IAO_0000115 "Focal emotional seizure with agitation is characterized by the presence of psychomotor agitation as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures arise in mesial temporal networks, especially the amygdala. They can be distinguished from panic attacks, by the presence of impaired awareness, automatisms and other features of an epileptic seizure appearing in a stereotyped manner. They are also distinguished from a focal autonomic seizure with epigastric sensation, where the onset seizure feature is an autonomic epigastric sensation, and fear may be present as a secondary feature." ; rdfs:label "Focal emotional seizure with agitation" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0032728 obo:IAO_0000115 "A focal atonic seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness atonic seizure" ; rdfs:subClassOf obo:HP_0020220, obo:HP_0032712 . obo:HP_0032729 obo:IAO_0000115 "Focal emotional seizure with pleasure is characterized by the presence of a positive emotional experience with pleasure, bliss, joy, enhanced personal well-being, heightened self-awareness or ecstasy." ; dcterms:creator ; a owl:Class ; rdfs:comment "This is a rare seizure type, seen in seizures arising in the anterior insular cortex." ; rdfs:label "Focal emotional seizure with pleasure" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0032730 obo:IAO_0000115 "A focal myoclonic seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness myoclonic seizure" ; rdfs:subClassOf obo:HP_0011166, obo:HP_0032712 . obo:HP_0032731 obo:IAO_0000115 "A type of focal hypermotor seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware hyperkinetic seizure" ; rdfs:subClassOf obo:HP_0011174, obo:HP_0020217 . obo:HP_0032732 obo:IAO_0000115 "A focal motor seizure with paresis / paralysis characterized by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor aware seizure with paresis/paralysis" ; a owl:Class ; rdfs:label "Focal aware motor seizure with paresis/paralysis" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032721 . obo:HP_0032733 obo:IAO_0000115 "A focal motor seizure with dysarthria / anarthria characterized by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor aware seizure with dysarthria/anarthria" ; a owl:Class ; rdfs:label "Focal aware motor seizure with dysarthria/anarthria" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032720 . obo:HP_0032734 obo:IAO_0000115 "A focal emotional seizure during which awareness is retained throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure" ; rdfs:subClassOf obo:HP_0025613, obo:HP_0032682 . obo:HP_0032735 obo:IAO_0000115 "Focal emotional seizure with anger in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with anger" ; rdfs:subClassOf obo:HP_0032734, obo:HP_0032736 . obo:HP_0032736 obo:IAO_0000115 "Focal emotional seizure with anger is characterized by the presence of anger, as an expressed or observed emotion, at the outset of the seizure. It may be accompanied by aggressive behaviour." ; dcterms:creator ; a owl:Class ; rdfs:comment "This seizure type localizes to prefrontal or mesial temporal regions of the brain." ; rdfs:label "Focal emotional seizure with anger" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0032737 obo:IAO_0000115 "Focal emotional seizure with paranoia is characterized by the presence of paranoia as an expressed or observed emotion at the outset of the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal emotional seizure with paranoia" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0032738 obo:IAO_0000115 "Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with fear/anxiety/panic" ; rdfs:subClassOf obo:HP_0032734, obo:HP_0032739 . obo:HP_0032739 obo:IAO_0000115 "Focal emotional seizure with anxiety is characterized by the presence of anxiety, fear or panic as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures arise in mesial temporal networks, especially the amygdala. They can be distinguished from panic attacks, by the presence of impaired awareness, automatisms and other features of an epileptic seizure appearing in a stereotyped manner. They are also distinguished from a focal autonomic seizure with epigastric sensation, where the onset seizure feature is an autonomic epigastric sensation, and fear may be present as a secondary feature." ; rdfs:label "Focal emotional seizure with fear/anxiety/panic" ; rdfs:subClassOf obo:HP_0025613 . obo:HP_0032740 obo:IAO_0000115 "A focal aware autonomic seizure has an initial manifestation pertaining to autonomic nervous system function, which may be objective (for example, pupillary dilation) or subjective (for example, nausea). As a type of focal aware seizure, awareness is retained throughout." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0011156" ; oboInOwl:hasExactSynonym "Focal autonomic seizures without altered responsiveness", "Localised autonomic seizures without altered responsiveness", "Localized autonomic seizures without altered responsiveness", "Partial autonomic seizures without altered responsiveness" ; a owl:Class ; rdfs:label "Focal aware autonomic seizure" ; rdfs:subClassOf obo:HP_0011154, obo:HP_0032682 . obo:HP_0032741 obo:IAO_0000115 "Focal emotional seizure with paranoia in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with paranoia" ; rdfs:subClassOf obo:HP_0032734, obo:HP_0032737 . obo:HP_0032742 obo:IAO_0000115 "Focal emotional seizure with pleasure in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with pleasure" ; rdfs:subClassOf obo:HP_0032729, obo:HP_0032734 . obo:HP_0032743 obo:IAO_0000115 "Focal emotional seizure with crying (dacrystic)in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with crying" ; rdfs:subClassOf obo:HP_0010820, obo:HP_0032734 . obo:HP_0032744 obo:IAO_0000115 "Focal emotional seizure with agitation in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with agitation" ; rdfs:subClassOf obo:HP_0032727, obo:HP_0032734 . obo:HP_0032745 obo:IAO_0000115 "Focal emotional seizure with laughing in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware emotional seizure with laughing" ; rdfs:subClassOf obo:HP_0010821, obo:HP_0032734 . obo:HP_0032746 obo:IAO_0000115 "A focal emotional seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure" ; rdfs:subClassOf obo:HP_0025613, obo:HP_0032716 . obo:HP_0032747 obo:IAO_0000115 "Focal emotional seizure with pleasure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with pleasure" ; rdfs:subClassOf obo:HP_0032729, obo:HP_0032746 . obo:HP_0032748 obo:IAO_0000115 "Focal emotional seizure with anger in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with anger" ; rdfs:subClassOf obo:HP_0032736, obo:HP_0032746 . obo:HP_0032749 obo:IAO_0000115 "Focal emotional seizure with paranoia in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with paranoia" ; rdfs:subClassOf obo:HP_0032737, obo:HP_0032746 . obo:HP_0032750 obo:IAO_0000115 "Focal emotional seizure with laughing in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with laughing" ; rdfs:subClassOf obo:HP_0010821, obo:HP_0032746 . obo:HP_0032751 obo:IAO_0000115 "Focal emotional seizure with crying in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with crying" ; rdfs:subClassOf obo:HP_0010820, obo:HP_0032746 . obo:HP_0032752 obo:IAO_0000115 "Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with fear/anxiety/panic" ; rdfs:subClassOf obo:HP_0032739, obo:HP_0032746 . obo:HP_0032753 obo:IAO_0000115 "A focal emotional seizure with agitation in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness emotional seizure with agitation" ; rdfs:subClassOf obo:HP_0032727, obo:HP_0032746 . obo:HP_0032754 obo:IAO_0000115 "A focal sensory seizure during which awareness is retained throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware sensory seizure" ; rdfs:subClassOf obo:HP_0011157, obo:HP_0032682 . obo:HP_0032755 obo:IAO_0000115 "A focal autonomic seizure characterised by impaired awareness at some point within the seizure." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0011155" ; oboInOwl:hasExactSynonym "Focal autonomic seizure with altered responsiveness", "Localised autonomic seizure with altered responsiveness", "Localized autonomic seizure with altered responsiveness", "Partial autonomic seizure with altered responsiveness" ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure" ; rdfs:subClassOf obo:HP_0011154, obo:HP_0032716 . obo:HP_0032756 obo:IAO_0000115 "A focal cognitive seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032875", "HP:0032931" ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure" ; rdfs:subClassOf obo:HP_0032680, obo:HP_0032716 . obo:HP_0032757 obo:IAO_0000115 "A focal hemiclonic seizure in which awareness is retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware hemiclonic seizure" ; rdfs:subClassOf obo:HP_0006813, obo:HP_0032711 . obo:HP_0032758 obo:IAO_0000115 "A type of focal myoclonic seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:comment "A single or short cluster of brief muscle contractions (jerks), each jerk is typically milliseconds in duration." ; rdfs:label "Focal aware myoclonic seizure" ; rdfs:subClassOf obo:HP_0011166, obo:HP_0020217 . obo:HP_0032759 obo:IAO_0000115 "A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation as its first clinical manifestation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal vestibular seizure", "Partial vestibular seizure", "Vestibular aura" ; a owl:Class ; rdfs:comment "These seizures involve the parietal cortex, temporo-parieto-occipital junction or parieto-temporal cortex." ; rdfs:label "Focal sensory seizure with vestibular features" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0032760 obo:IAO_0000115 "A seizure characterized by sensations of feeling hot or cold as its first clinical manifestation." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal sensory seizure with hot-cold sensations" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0032761 obo:IAO_0000115 "A focal autonomic seizure with pallor / flushing characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with pallor/flushing" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032762 . obo:HP_0032762 obo:IAO_0000115 "A type of focal autonomic seizure characterized by changes of the skin as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with pallor/flushing" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032763 obo:IAO_0000115 "A type of focal autonomic seizure characterized by pupillary dilatation or contraction as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with pupillary dilation/constriction" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032764 obo:IAO_0000115 "A type of focal autonomic seizure characterised by penile erection as the intial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with erection" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032765 obo:IAO_0000115 "A type of focal autonomic seizure characterized by an urge to unripe or defecate as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with urge to urinate/defecate" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032766 obo:IAO_0000115 "A type of focal autonomic seizure characterized by changes in respiratory rate as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with hypoventilation/hyperventilation/altered respiration" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032767 obo:IAO_0000115 "A type of focal autonomic seizure characterized by piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with piloerection" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032768 obo:IAO_0000115 "A focal autonomic seizure with pupillary dilation / constriction characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with pupillary dilation/constriction" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032763 . obo:HP_0032769 obo:IAO_0000115 "An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032766 . obo:HP_0032770 obo:IAO_0000115 "A focal autonomic seizure with erection characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with erection" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032764 . obo:HP_0032771 obo:IAO_0000115 "A type of focal autonomic seizure characterized by lacrimation as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal autonomic seizure with lacrimation" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032772 obo:IAO_0000115 "A Focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with piloerection" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032767 . obo:HP_0032773 obo:IAO_0000115 "A type of focal autonomic seizure characterized by changes in heart rate as the initial semiological feature." ; dcterms:creator ; a owl:Class ; rdfs:comment "Includes seizure characterized predominantly by chronotropic features such as bradycardia, tachycardia and asystole as the initial semiological feature." ; rdfs:label "Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole" ; rdfs:subClassOf obo:HP_0011154 . obo:HP_0032774 obo:IAO_0000115 "A focal autonomic seizure with urge to urinate / defecate characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with urge to urinate/defecate" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032765 . obo:HP_0032775 obo:IAO_0000115 "An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with hypoventilation/hyperventilation/altered respiration" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032766 . obo:HP_0032776 dcterms:creator ; a owl:Class ; rdfs:comment "A focal autonomic seizure with lacrimation characterized by retained awareness throughout the seizure." ; rdfs:label "Focal aware autonomic seizure with lacrimation" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032771 . obo:HP_0032777 obo:IAO_0000115 "A focal autonomic seizure with pallor / flushing characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with pallor/flushing" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032762 . obo:HP_0032778 obo:IAO_0000115 "A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena" ; rdfs:subClassOf obo:HP_0011159, obo:HP_0032755 . obo:HP_0032779 obo:IAO_0000115 "A focal autonomic seizure with pupillary dilation / constriction characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with pupillary dilation/constriction" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032763 . obo:HP_0032780 obo:IAO_0000115 "A focal autonomic seizure with erection characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with erection" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032764 . obo:HP_0032781 obo:IAO_0000115 "A focal autonomic seizure with urge to urinate / defecate characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with urge to urinate/defecate" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032765 . obo:HP_0032782 obo:IAO_0000115 "A focal autonomic seizure with lacrimation characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with lacrimation" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032771 . obo:HP_0032783 obo:IAO_0000115 "A focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with piloerection" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032767 . obo:HP_0032784 obo:IAO_0000115 "An autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with palpitations/tachycardia/bradycardia/asystole" ; rdfs:subClassOf obo:HP_0032740, obo:HP_0032773 . obo:HP_0032785 obo:IAO_0000115 "A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena" ; rdfs:subClassOf obo:HP_0011159, obo:HP_0032740 . obo:HP_0032786 obo:IAO_0000115 "A migrating focal seizure is a seizure that involves different body parts, usually without overlap, in a consecutive manner so that the offset of a seizure in one part coincides with its onset in another, even shifting multiple times between the sides of the body. They can be associated with autonomic manifestations." ; dcterms:creator ; oboInOwl:hasExactSynonym "Migrating partial seizure" ; a owl:Class ; rdfs:comment "Migrating focal seizures are one of the pathognomonic features of Epilepsy of infancy with Migrating Focal Seizures (also known as Migrating Partial Seizures of Infancy, MPSI), which is an epileptic encephalopathy characterized by normal early development, refractory focal seizures arising independently from both hemispheres, and severe psychomotor retardation. EEG correlate shows migrating ictal foci, shifting areas of ictal onset between hemispheres." ; rdfs:label "Migrating focal seizure" ; rdfs:subClassOf obo:HP_0007359 . obo:HP_0032787 obo:IAO_0000115 "A focal sensory seizure in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure" ; rdfs:subClassOf obo:HP_0011157, obo:HP_0032716 . obo:HP_0032788 obo:IAO_0000115 "A focal autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness autonomic seizure with palpitations/tachycardia/bradycardia/asystole" ; rdfs:subClassOf obo:HP_0032755, obo:HP_0032773 . obo:HP_0032789 obo:IAO_0000115 "A focal behavior arrest seizure characterised by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal aware behaviour arrest seizure" ; a owl:Class ; rdfs:label "Focal aware behavior arrest seizure" ; rdfs:subClassOf obo:HP_0011173, obo:HP_0032682 . obo:HP_0032790 obo:IAO_0000115 "A focal behavior arrest seizure characterised by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal impaired awareness behaviour arrest seizure" ; a owl:Class ; rdfs:label "Focal impaired awareness behavior arrest seizure" ; rdfs:subClassOf obo:HP_0011146, obo:HP_0011173, obo:HP_0032716 . obo:HP_0032791 obo:IAO_0000115 "A focal cognitive seizure with anomia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with anomia" ; rdfs:subClassOf obo:HP_0032701, obo:HP_0032756 . obo:HP_0032792 obo:IAO_0000115 "A tonic seizure is a type of motor seizure characterised by unilateral or bilateral limb stiffening or elevation, often with neck stiffening." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term describes the initial semiology of the seizure without specifying whether the onset is focal or generalized. Thus it can be used for coding tonic seizures when the onset is not known. The tonic contraction of muscles can result in a tremor, not to be confused with a clonic phase. This term does not apply to seizures with a tonic phase followed a clonic phase, see bilateral tonic-clonic seizure." ; rdfs:label "Tonic seizure" ; rdfs:subClassOf obo:HP_0020219 . obo:HP_0032793 obo:IAO_0000115 "A focal cognitive seizure with receptive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with receptive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032696, obo:HP_0032756 . obo:HP_0032794 obo:IAO_0000115 "A myoclonic seizure is a type of motor seizure characterised by sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term describes the initial semiology of the seizure without specifying whether the onset is focal or generalized. Thus it can be used for coding myoclonic seizures when the onset is not known." ; rdfs:label "Myoclonic seizure" ; rdfs:subClassOf obo:HP_0020219 . obo:HP_0032795 obo:IAO_0000115 "A generalized myoclonic-tonic-clonic seizure is a type of generalized motor seizure characterised by a single or multiple jerks of limbs bilaterally, followed by tonic and clonic phases. The initial jerks can be considered to be either a brief period of clonus or myoclonus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Generalised myoclonic-tonic-clonic seizure", "Generalised onset myoclonic-tonic-clonic seizure", "Generalised-onset myoclonic-tonic-clonic seizure", "Generalized-onset myoclonic-tonic-clonic seizure", "generalised onset myoclonic-tonic-clonic seizure", "generalized onset myoclonic-tonic-clonic seizure" ; a owl:Class ; rdfs:label "Generalized myoclonic-tonic-clonic seizure" ; rdfs:subClassOf obo:HP_0032677 . obo:HP_0032796 obo:IAO_0000115 "A focal cognitive seizure with left-right confusion characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with left-right confusion" ; rdfs:subClassOf obo:HP_0032700, obo:HP_0032756 . obo:HP_0032797 obo:IAO_0000115 "Seizures characterized by olfactory phenomena at onset - usually an odor, which is often unpleasant." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures involve the mesial temporal or orbitofrontal regions." ; rdfs:label "Focal aware sensory seizure with olfactory features" ; rdfs:subClassOf obo:HP_0011161, obo:HP_0032754 . obo:HP_0032798 obo:IAO_0000115 "A focal cognitive seizure with neglect characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with neglect" ; rdfs:subClassOf obo:HP_0032693, obo:HP_0032756 . obo:HP_0032799 obo:IAO_0000115 "A focal hemiclonic seizure in which awareness is impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness hemiclonic seizure" ; rdfs:subClassOf obo:HP_0006813, obo:HP_0032725 . obo:HP_0032800 obo:IAO_0000115 "A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures involve the parietal cortex, temporo-parieto-occipital junction or parieto-temporal cortex." ; rdfs:label "Focal aware sensory seizure with vestibular features" ; rdfs:subClassOf obo:HP_0032754, obo:HP_0032759 . obo:HP_0032801 obo:IAO_0000115 "A focal cognitive seizure with memory impairment characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with memory impairment" ; rdfs:subClassOf obo:HP_0032687, obo:HP_0032756 . obo:HP_0032802 obo:IAO_0000115 "A focal cognitive seizure with dyscalculia / acalculia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with dyscalculia/acalculia" ; rdfs:subClassOf obo:HP_0032691, obo:HP_0032756 . obo:HP_0032803 obo:IAO_0000115 "A focal cognitive seizure with dysgraphia / agraphia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with dysgraphia/agraphia" ; rdfs:subClassOf obo:HP_0032699, obo:HP_0032756 . obo:HP_0032804 obo:IAO_0000115 "A focal sensory seizure with olfaction in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with olfactory features" ; rdfs:subClassOf obo:HP_0011161, obo:HP_0032787 . obo:HP_0032805 obo:IAO_0000115 "A focal sensory seizure with vestibular features in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with vestibular features" ; rdfs:subClassOf obo:HP_0032759, obo:HP_0032787 . obo:HP_0032806 obo:IAO_0000115 "A focal sensory seizure with visual features in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with visual features" ; rdfs:subClassOf obo:HP_0011165, obo:HP_0032787 . obo:HP_0032807 obo:IAO_0000115 "A seizure occurring within the neonatal period (28 days beyond the full term date)." ; dcterms:creator ; a owl:Class ; rdfs:comment "This term encompasses clinical only (motor or non-motor without electrographic confirmation), electro-clinical and electrographic only seizures. Where the seizure also meets the definition of status epilepticus it should be coded twice." ; rdfs:label "Neonatal seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0032808 obo:IAO_0000115 "Neonatal seizure is a seizure type that occurs in neonatal period and is characterized by an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end. This event can be associated or not with a clinical manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Neonatal seizures need to be considered as a special category because of biological peculiarities, such as the immaturity of the neonatal central nervous system. Therefore, seizures are defined first as an electrographic event, that can be associated or not with clinical manifestations. Seizure types are further classified following ILAE 2017 seizure classification, however awarness is not assessable in neonates. The distinction motor vs. non motor seizure is kept, but here it reflects the predominant clinical manifestation, rather than the onset of the seizure as in adult classification." ; rdfs:label "Neonatal seizure with electrographic correlate" ; rdfs:subClassOf obo:HP_0032807 . obo:HP_0032809 obo:IAO_0000115 "Neonatal electro-clinical seizure is an electrographic event occurring in neonatal period and coupled with a clinical manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "The predominant clinical feature defines the neonatal electro-clinical seizure sub-types; unlike in adults, where the semiology at onset defines the seizure type." ; rdfs:label "Neonatal electro-clinical seizure" ; rdfs:subClassOf obo:HP_0032808 . obo:HP_0032810 obo:IAO_0000115 "A seizure characterized by a sensation in the head such as light-headedness or headache as its first clinical manifestation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Cephalic aura", "Focal seizure with cephalic sensation", "Partial seizure with cephalic sensation" ; a owl:Class ; rdfs:label "Focal sensory seizure with cephalic sensation" ; rdfs:subClassOf obo:HP_0011157 . obo:HP_0032811 obo:IAO_0000115 "Neonatal electrographic only seizure is an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end, which is not associated with a clinical manifestation." ; dcterms:creator ; a owl:Class ; rdfs:comment "The duration of the seizures has to be sufficient to demonstrate evolution in frequency and morphology of the discharges on electroencephalography, which will depend on the frequency of the discharge. The duration is arbitrary but needs to be sufficient to allow recognition of onset, evolution and resolution of an abnormal discharge. This type of seizure is particular to the neonatal period; beyond this electrographic appearance of a seizure must be associated with a clinical correlate to be classed as a seizure." ; rdfs:label "Neonatal electrographic only seizure" ; rdfs:subClassOf obo:HP_0032808 . obo:HP_0032812 dcterms:creator ; a owl:Class ; rdfs:label "Neonatal electro-clinical non-motor seizure" ; rdfs:subClassOf obo:HP_0032809 . obo:HP_0032813 obo:IAO_0000115 "Neonatal electro-clinical motor seizure is a type of neonatal electro-clinical seizure with predominant motor features." ; dcterms:creator ; a owl:Class ; rdfs:comment "Neonatal motor seizures may be further sub-classified as seizures occurring with presentations such as: automatisms, clonic, epileptic spams, myoclonic, sequential, tonic." ; rdfs:label "Neonatal electro-clinical motor seizure" ; rdfs:subClassOf obo:HP_0032809 . obo:HP_0032814 obo:IAO_0000115 "Neonatal electro-clinical clonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups; it can be symmetric or asymmetric." ; dcterms:creator ; oboInOwl:hasExactSynonym "Neonatal electroclinical clonic seizure" ; a owl:Class ; rdfs:label "Neonatal electro-clinical clonic seizure" ; rdfs:subClassOf obo:HP_0032813 . obo:HP_0032815 obo:IAO_0000115 "Neonatal electro-clinical myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Neonatal electroclinical myoclonic seizure" ; a owl:Class ; rdfs:comment "Clinically difficult to differentiate from non-epileptic myoclonus." ; rdfs:label "Neonatal electro-clinical myoclonic seizure" ; rdfs:subClassOf obo:HP_0032813 . obo:HP_0032816 obo:IAO_0000115 "Neonatal multifocal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at multiple sites." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal multifocal myoclonic seizure" ; rdfs:subClassOf obo:HP_0032815 . obo:HP_0032817 obo:IAO_0000115 "Neonatal focal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) which occurs focally." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal focal myoclonic seizure" ; rdfs:subClassOf obo:HP_0032815 . obo:HP_0032818 obo:IAO_0000115 "Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is unilateral regularly repeating jerking involving the same muscle groups." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal focal clonic seizure" ; rdfs:subClassOf obo:HP_0032814 . obo:HP_0032819 obo:IAO_0000115 "Neonatal bilateral clonic seizure is a type of neonatal electro-clinical clonic seizure where the clonic jerking is bilateral." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral clonic seizure" ; rdfs:subClassOf obo:HP_0032814 . obo:HP_0032820 obo:IAO_0000115 "Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups, which occurs at multiple sites." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal multifocal clonic seizure" ; rdfs:subClassOf obo:HP_0032814 . obo:HP_0032821 obo:IAO_0000115 "Neonatal electro-clinical tonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a sustained increase in muscle tone, usually focal, that can be unilateral or bilateral, and lasting a few seconds to minutes." ; dcterms:creator ; a owl:Class ; rdfs:comment "Usually focal, unilateral or bilateral asymmetric. Generalized tonic posturing is often not of epileptic origin." ; rdfs:label "Neonatal electro-clinical tonic seizure" ; rdfs:subClassOf obo:HP_0032813 . obo:HP_0032822 obo:IAO_0000115 "Neonatal electro-clinical non-motor autonomic seizure is a type of neonatal electro-clinical seizure with predominant features of autonomic alterations, involving cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor, and thermoregulatory functions. May present as apnea." ; dcterms:creator ; a owl:Class ; rdfs:comment "May involve respiration (apnea). Typically seen with other seizure manifestations. EEG confirmation is mandatory." ; rdfs:label "Neonatal electro-clinical autonomic seizure" ; rdfs:subClassOf obo:HP_0032812 . obo:HP_0032823 obo:IAO_0000115 "Neonatal electro-clinical non-motor seizure with behavior arrest is a type of neonatal electro-clinical seizure characterized by an arrest of activities, freezing, immobilization, with or without apnea and/or other autonomic manifestations." ; dcterms:creator ; oboInOwl:hasExactSynonym "Neonatal electro-clinical seizure with behaviour arrest", "Neonatal electroclinical seizure with behavioural arrest" ; a owl:Class ; rdfs:comment "May be focal and/or followed by apnea, other autonomic manifestations and motor seizures." ; rdfs:label "Neonatal electro-clinical seizure with behavior arrest" ; rdfs:subClassOf obo:HP_0032812 . obo:HP_0032824 obo:IAO_0000115 "Neonatal focal tonic seizure is a type of neonatal electro-clinical tonic seizure with a focal sustained increase in muscle tone, lasting a few seconds to minutes." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal focal tonic seizure" ; rdfs:subClassOf obo:HP_0032821 . obo:HP_0032825 obo:IAO_0000115 "Neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic signs, often changing lateralization within or between seizures." ; dcterms:creator ; oboInOwl:hasExactSynonym "Neonatal electroclinical sequential seizure" ; a owl:Class ; rdfs:comment "No predominant feature can be determined, instead the seizure presents with a variety of clinical signs. Several features typically occur in a sequence, often with changing lateralization within or between seizures. Most commonly seen in epilepsies of genetic aetiology." ; rdfs:label "Neonatal electro-clinical sequential seizure" ; rdfs:subClassOf obo:HP_0032809 . obo:HP_0032826 obo:IAO_0000115 "Focal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic focal signs, often changing lateralization within or between seizures." ; dcterms:creator ; a owl:Class ; rdfs:comment "No predominant feature can be determined, instead the seizure presents with a variety of clinical signs. Several features typically occur in a sequence, often with changing lateralization within or between seizures. Most commonly seen in epilepsies of genetic etiology." ; rdfs:label "Focal neonatal sequential seizure" ; rdfs:subClassOf obo:HP_0032825 . obo:HP_0032827 obo:IAO_0000115 "Multifocal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic multifocal signs." ; dcterms:creator ; a owl:Class ; rdfs:comment "No predominant feature can be determined, instead the seizure presents with a variety of clinical signs. Several features typically occur in a sequence, often with changing lateralization within or between seizures. Most commonly seen in epilepsies of genetic etiology." ; rdfs:label "Multifocal neonatal sequential seizure" ; rdfs:subClassOf obo:HP_0032825 . obo:HP_0032828 obo:IAO_0000115 "Neonatal bilateral symmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body symmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral symmetric tonic seizure" ; rdfs:subClassOf obo:HP_0032821 . obo:HP_0032829 obo:IAO_0000115 "Neonatal electro-clinical motor seizure with automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, and in association with other features." ; dcterms:creator ; oboInOwl:hasExactSynonym "Neonatal electroclinical motor seizure with automatism" ; a owl:Class ; rdfs:comment "Normal and abnormal behavior in term and preterm infants may mimic ictal automatisms." ; rdfs:label "Neonatal electro-clinical motor seizure with automatism" ; rdfs:subClassOf obo:HP_0032813 . obo:HP_0032830 obo:IAO_0000115 "Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with coordinated motor activity, typically oral, usually with impaired awareness, occurring at both sides of the body asymmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal seizure with bilateral asymmetric automatism" ; rdfs:subClassOf obo:HP_0032829 . obo:HP_0032831 obo:IAO_0000115 "Neonatal bilateral asymmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body but asymmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral asymmetric tonic seizure" ; rdfs:subClassOf obo:HP_0032821 . obo:HP_0032832 obo:IAO_0000115 "Neonatal bilateral asymmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body asymmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral asymmetric myoclonic seizure" ; rdfs:subClassOf obo:HP_0032815 . obo:HP_0032833 obo:IAO_0000115 "A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: grimacing, head nodding, or subtle eye movements. May occur in clusters." ; dcterms:creator ; a owl:Class ; rdfs:comment "May be difficult to differentiate from myoclonic seizures without electromyography." ; rdfs:label "Neonatal epileptic spasm" ; rdfs:subClassOf obo:HP_0032813 . obo:HP_0032834 obo:IAO_0000115 "Neonatal seizure with bilateral asymmetric automatisms is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at one side of the body." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal seizure with unilateral automatism" ; rdfs:subClassOf obo:HP_0032829 . obo:HP_0032835 obo:IAO_0000115 "Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at both sides of the body symmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal seizure with bilateral symmetric automatism" ; rdfs:subClassOf obo:HP_0032829 . obo:HP_0032836 obo:IAO_0000115 "Neonatal bilateral symmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body symmetrically." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral symmetric myoclonic seizure" ; rdfs:subClassOf obo:HP_0032815 . obo:HP_0032837 obo:IAO_0000115 "Asymmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting asymmetrically with a variety of clinical and electrographic signs, often changing lateralization within or between seizures." ; dcterms:creator ; a owl:Class ; rdfs:comment "No predominant feature can be determined, instead the seizure presents with a variety of clinical signs. Several features typically occur in a sequence, often with changing lateralization within or between seizures. Most commonly seen in epilepsies of genetic etiology." ; rdfs:label "Bilateral asymmetric neonatal sequential seizure" ; rdfs:subClassOf obo:HP_0032825 . obo:HP_0032838 obo:IAO_0000115 "Neonatal unilateral epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs at one side of the body." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal unilateral epileptic spasm" ; rdfs:subClassOf obo:HP_0032833 . obo:HP_0032839 obo:IAO_0000115 "Symmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting symmetrically but with a variety of clinical and electrographic signs." ; dcterms:creator ; a owl:Class ; rdfs:comment "No predominant feature can be determined, instead the seizure presents with a variety of clinical signs. Several features typically occur in a sequence, often with changing lateralization within or between seizures. Most commonly seen in epilepsies of genetic etiology." ; rdfs:label "Bilateral symmetric neonatal sequential seizure" ; rdfs:subClassOf obo:HP_0032825 . obo:HP_0032840 obo:IAO_0000115 "Neonatal bilateral symmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs symmetrically at both sides of the body." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral symmetric epileptic spasm" ; rdfs:subClassOf obo:HP_0032833 . obo:HP_0032841 obo:IAO_0000115 "Neonatal bilateral asymmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs asymmetrically at both sides of the body." ; dcterms:creator ; a owl:Class ; rdfs:label "Neonatal bilateral asymmetric epileptic spasm" ; rdfs:subClassOf obo:HP_0032833 . obo:HP_0032842 obo:IAO_0000115 "A type of epileptic spasm of generalized onset." ; dcterms:creator ; oboInOwl:hasExactSynonym "Generalised onset epileptic spasm", "Generalised-onset epileptic spasm", "Generalized onset epileptic spasm" ; a owl:Class ; rdfs:label "Generalized-onset epileptic spasm" ; rdfs:subClassOf obo:HP_0011097, obo:HP_0032677 . obo:HP_0032843 obo:IAO_0000115 "A type of epileptic spasm of focal onset." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal onset epileptic spasm" ; a owl:Class ; rdfs:comment "The degree of awareness during the seizure is rarely known." ; rdfs:label "Focal-onset epileptic spasm" ; rdfs:subClassOf obo:HP_0011097, obo:HP_0011153 . obo:HP_0032844 obo:IAO_0000115 "A type of focal-onset epileptic spasm in which awareness is impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness epileptic spasm" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032843 . obo:HP_0032845 obo:IAO_0000115 "A type of focal-onset epileptic spasm in which awareness is preserved throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware epileptic spasm" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032843 . obo:HP_0032846 obo:IAO_0000115 "A type of focal motor seizure characterized by a sudden interruption in normal tonic muscle activity lasting 500 ms or less, without evidence of preceding myoclonus as the initial semiological manifestation. The interruption in muscle tone is briefer than seen in a focal atonic seizure." ; dcterms:creator ; a owl:Class ; rdfs:comment "This is seen in the epilepsy syndrome atypical childhood epilepsy with centrotemporal spikes, where an upper limb or the head is affected by localized brief interruption in normal muscle tone. The patient may correct for the loss of tone with overshoot past the primary position." ; rdfs:label "Focal motor seizure with negative myoclonus" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032847 obo:IAO_0000115 "Focal seizure characterized at onset by clonic movements affecting half of the face with impairment of awareness in which awareness is impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness hemifacial clonic seizure" ; rdfs:subClassOf obo:HP_0007332, obo:HP_0032725 . obo:HP_0032848 obo:IAO_0000115 "A focal cognitive seizure with neglect characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with neglect" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032693 . obo:HP_0032849 obo:IAO_0000115 "Aphasic status epilepticus is a type of focal non-convulsive status epilepticus without coma characterized by a cognitive (rather than motor) language deficit." ; dcterms:creator ; a owl:Class ; rdfs:label "Aphasic status epilepticus" ; rdfs:subClassOf obo:HP_0032673 . obo:HP_0032850 obo:IAO_0000115 "A focal cognitive seizure with expressive dysphasia / aphasia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with expressive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032702 . obo:HP_0032851 obo:IAO_0000115 "A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis." ; dcterms:creator ; a owl:Class ; rdfs:comment "More complex visual hallucinations such as seeing formed images are considered a focal cognitive seizure. Focal sensory visual seizures arise in the occipital lobe." ; rdfs:label "Focal aware sensory seizure with visual features" ; rdfs:subClassOf obo:HP_0011165, obo:HP_0032754 . obo:HP_0032852 obo:IAO_0000115 "A focal cognitive seizure with conduction dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with conduction dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032698, obo:HP_0032756 . obo:HP_0032853 obo:IAO_0000115 "A focal sensory seizure with hot-cold sensations in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with hot-cold sensations" ; rdfs:subClassOf obo:HP_0032760, obo:HP_0032787 . obo:HP_0032854 obo:IAO_0000115 "Focal seizure characterized at onset by clonic movements affecting half of the face with retained awareness throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware hemifacial clonic seizure" ; rdfs:subClassOf obo:HP_0007332, obo:HP_0032711 . obo:HP_0032855 obo:IAO_0000115 "Generalised myoclonic-tonic-clonic seizure provoked by flashing or flickering light." ; dcterms:creator ; oboInOwl:hasExactSynonym "Photically induced myoclonic-tonic-clonic seizure" ; a owl:Class ; rdfs:label "Photosensitive myoclonic-tonic-clonic seizure" ; rdfs:subClassOf obo:HP_0020216, obo:HP_0032795 . obo:HP_0032856 obo:IAO_0000115 "A type of focal bilateral motor seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware bilateral motor seizure" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032715 . obo:HP_0032857 obo:IAO_0000115 "A focal motor seizure with negative myoclonus characterized by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor aware seizure with negative myoclonus" ; a owl:Class ; rdfs:label "Focal aware motor seizure with negative myoclonus" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032846 . obo:HP_0032858 obo:IAO_0000115 "A focal motor seizure with negative myoclonus characterized by impairement of awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure with negative myoclonus" ; a owl:Class ; rdfs:label "Focal impaired awareness motor seizure with negative myoclonus" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032846 . obo:HP_0032859 obo:IAO_0000115 "A focal motor seizure with paresis / paralysis characterized by impaired awareness at some point during the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor impaired awareness seizure with paresis/paralysis" ; a owl:Class ; rdfs:label "Focal impaired awareness motor seizure with paresis/paralysis" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032721 . obo:HP_0032860 obo:IAO_0000115 "Generalized non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically generalized. It is a prolonged absence seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence status epilepticus", "Generalised non-convulsive status epilepticus without coma", "Petit mal status epilepticus" ; a owl:Class ; rdfs:label "Generalized non-convulsive status epilepticus without coma" ; rdfs:subClassOf obo:HP_0032671 . obo:HP_0032861 obo:IAO_0000115 "Focal non-convulsive status epilepticus with impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness is impaired." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal non-convulsive status epilepticus with impairment of awareness" ; a owl:Class ; rdfs:comment "Semiology may include autonomic, sensory, visual, olfactory, gustatory, emotional/psychic/experiential, or cognitive symptoms, depending on the fluctuation of consciousness. In 2015, the ILAE Task Force on Classification of Status Epilepticus proposed that time t1 (indicating the time that emergency treatment should be started because the seizure is unlikely to terminate spontaneously) is 10 minutes and t2 (the time at which long-term consequences of the seizure may be expected) is at least 60 minutes for focal status epilepticus with impaired consciousness." ; rdfs:label "Focal non-convulsive status epilepticus with impairment of consciousness" ; rdfs:subClassOf obo:HP_0032673 . obo:HP_0032862 obo:IAO_0000115 "A type of focal motor status epilepticus characterized by prolonged ictal paresis or inhibitory motor seizures." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal inhibitory status epilepticus" ; a owl:Class ; rdfs:comment "Ictal paresis or inhibitory motor seizures are a relatively rare type of seizure characterized by an inability to initiate or continue movements despite retained awareness, which could last for many hours or even days. These manifest with paresis/paralysis of 1 side of the body (hemiplegia with or without facial involvement) or 1 extremity (upper or lower monoplegia) and are often preceded by other objective or subjective ictal symptoms, which may also occur concomitantly with the paresis or independently." ; rdfs:label "Status epilepticus with ictal paresis" ; rdfs:subClassOf obo:HP_0032663 . obo:HP_0032863 obo:IAO_0000115 "Typical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged typical absence seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Simple absence status epilepticus" ; a owl:Class ; rdfs:comment "This may occur as a consequence of medication withdrawal in absence epilepsy syndromes." ; rdfs:label "Typical absence status epilepticus" ; rdfs:subClassOf obo:HP_0032860 . obo:HP_0032864 obo:IAO_0000115 "A type of focal sensory seizure with auditory features during which awareness is retained throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:comment "This type of seizure is characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones. More complex auditory hallucinations such as voices are considered a focal cognitive seizure. Focal sensory auditory seizures involve auditory cortex in the lateral superior temporal lobe." ; rdfs:label "Focal aware sensory seizure with auditory features" ; rdfs:subClassOf obo:HP_0011158, obo:HP_0032754 . obo:HP_0032865 obo:IAO_0000115 "Myoclonic absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged myoclonic absence seizure. Myoclonic absence status epilepticus consists of proximal, predominantly upper extremity myoclonic jerks corresponding with 3 Hz spike-wave discharges in the EEG." ; dcterms:creator ; a owl:Class ; rdfs:label "Myoclonic absence status epilepticus" ; rdfs:subClassOf obo:HP_0032860 . obo:HP_0032866 obo:IAO_0000115 "A type of focal motor status epilepticus characterized by repetitive and rapid saccades, in association with epileptic discharges." ; dcterms:creator ; a owl:Class ; rdfs:label "Oculoclonic status epilepticus" ; rdfs:subClassOf obo:HP_0032663 . obo:HP_0032867 obo:IAO_0000115 "Refractory status epilepticus is defined as status epilepticus continuing despite two appropriately selected and dosed antiepileptic drugs, including a benzodiazepine." ; dcterms:creator ; a owl:Class ; rdfs:label "Refractory status epilepticus" ; rdfs:subClassOf obo:HP_0002133 . obo:HP_0032868 obo:IAO_0000115 "Super-refractory status epilepticus is defined as refractory status epilepticus continuing for 24 h or more following initiation of anesthetic medications, including cases in which seizure control is attained after induction of anesthetic drugs but recurs on weaning the patient off the anesthetic agent." ; dcterms:creator ; a owl:Class ; rdfs:label "Super-refractory status epilepticus" ; rdfs:subClassOf obo:HP_0032867 . obo:HP_0032869 obo:IAO_0000115 "Focal non-convulsive status epilepticus without impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness remains intact." ; dcterms:creator ; oboInOwl:hasExactSynonym "Aura continua", "Focal non-convulsive status epilepticus with retained awareness", "Focal non-convulsive status epilepticus without impairment of awareness" ; a owl:Class ; rdfs:comment "Semiology may include autonomic, sensory, visual, olfactory, gustatory, emotional/psychic/experiential, or cognitive symptoms. In 2015, the ILAE Task Force on Classification of Status Epilepticus did not propose a specific time t1 (indicating the time that emergency treatment should be started because the seizure is unlikely to terminate spontaneously) or t2 (the time at which long-term consequences of the seizure may be expected) for focal status epilepticus without impaired consciousness." ; rdfs:label "Focal non-convulsive status epilepticus without impairment of consciousness" ; rdfs:subClassOf obo:HP_0032673 . obo:HP_0032870 obo:IAO_0000115 "A focal cognitive seizure with dyslexia / alexia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with dyslexia/alexia" ; rdfs:subClassOf obo:HP_0032694, obo:HP_0032756 . obo:HP_0032871 obo:IAO_0000115 "A focal cognitive seizure with hallucination characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with hallucination" ; rdfs:subClassOf obo:HP_0012007, obo:HP_0032681 . obo:HP_0032872 obo:IAO_0000115 "A focal cognitive seizure with illusion characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with illusion" ; rdfs:subClassOf obo:HP_0012008, obo:HP_0032756 . obo:HP_0032873 obo:IAO_0000115 "A seizure characterized by a sensation in the head such as light-headedness or headache." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware sensory seizure with cephalic sensation" ; rdfs:subClassOf obo:HP_0032754, obo:HP_0032810 . obo:HP_0032874 obo:IAO_0000115 "A focal cognitive seizure with auditory agnosia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with auditory agnosia" ; rdfs:subClassOf obo:HP_0032685, obo:HP_0032756 . obo:HP_0032875 obo:IAO_0100001 "HP:0032756" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Focal impaired awareness cognitive seizure with impaired responsiveness" ; owl:deprecated true . obo:HP_0032876 obo:IAO_0000115 "A focal cognitive seizure with conduction dysphasia / aphasia characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with conduction dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032681, obo:HP_0032698 . obo:HP_0032877 obo:IAO_0000115 "A seizure characterized by sensations of feeling hot and then cold." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware sensory seizure with hot-cold sensations" ; rdfs:subClassOf obo:HP_0032754, obo:HP_0032760 . obo:HP_0032878 obo:IAO_0000115 "A focal sensory seizure with cephalic sensation in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with cephalic sensation" ; rdfs:subClassOf obo:HP_0032787, obo:HP_0032810 . obo:HP_0032879 obo:IAO_0000115 "A focal cognitive epileptic seizure with dissociation at the onset of the seizure and with impairment of awareness at at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness seizure with dissociation at onset" ; rdfs:subClassOf obo:HP_0032689, obo:HP_0032756 . obo:HP_0032880 obo:IAO_0000115 "A focal sensory seizure with auditory features in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with auditory features" ; rdfs:subClassOf obo:HP_0011158, obo:HP_0032787 . obo:HP_0032881 obo:IAO_0100001 "HP:0032681" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Focal aware cognitive seizure with impaired responsiveness" ; owl:deprecated true . obo:HP_0032882 obo:IAO_0000115 "A focal cognitive seizure with deja vu / jamais vu characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with deja vu/jamais vu" ; rdfs:subClassOf obo:HP_0012004, obo:HP_0032756 . obo:HP_0032883 obo:IAO_0000115 "A focal cognitive seizure with deja vu / jamais vu characterized by retained awareness throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware cognitive seizure with deja vu/jamais vu" ; rdfs:subClassOf obo:HP_0012004, obo:HP_0032681 . obo:HP_0032884 obo:IAO_0000115 "A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move. Awareness is retained throughout the seizure." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures involve the sensorimotor cortex." ; rdfs:label "Focal aware sensory seizure with somatosensory features" ; rdfs:subClassOf obo:HP_0011163, obo:HP_0032754 . obo:HP_0032885 obo:IAO_0000115 "A focal cognitive seizure with hallucination characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with hallucination" ; rdfs:subClassOf obo:HP_0012007, obo:HP_0032756 . obo:HP_0032886 obo:IAO_0000115 "A focal cognitive seizure with expressive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with expressive dysphasia/aphasia" ; rdfs:subClassOf obo:HP_0032702, obo:HP_0032756 . obo:HP_0032887 obo:IAO_0000115 "Generalized atonic seizure is a type of generalized motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1-2 s, involving head, trunk, jaw, or limb musculature." ; dcterms:creator ; oboInOwl:hasExactSynonym "Generalised atonic seizure" ; a owl:Class ; rdfs:comment "Atonic means without tone. When leg tone is lost during a generalized atonic seizure, the patient falls on the buttocks or sometimes forward onto the knees and face. Recovery is usually within seconds." ; rdfs:label "Generalized atonic seizure" ; rdfs:subClassOf obo:HP_0010819, obo:HP_0032677 . obo:HP_0032888 obo:IAO_0000115 "A focal cognitive seizure with forced thinking characterized by impairment of awareness at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness cognitive seizure with forced thinking" ; rdfs:subClassOf obo:HP_0032692, obo:HP_0032756 . obo:HP_0032889 obo:IAO_0000115 "A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes." ; dcterms:creator ; a owl:Class ; rdfs:comment "These seizures involve the parietal operculum and the insula." ; rdfs:label "Focal aware sensory seizure with gustatory features" ; rdfs:subClassOf obo:HP_0011160, obo:HP_0032754 . obo:HP_0032890 obo:IAO_0000115 "A focal sensory seizure with somatosensory features in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with somatosensory features" ; rdfs:subClassOf obo:HP_0011163, obo:HP_0032787 . obo:HP_0032891 obo:IAO_0000115 "A focal motor seizure with version characterized by retained awareness throughout the seizure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal motor aware seizure with version" ; a owl:Class ; rdfs:label "Focal aware motor seizure with version" ; rdfs:subClassOf obo:HP_0011175, obo:HP_0020217 . obo:HP_0032892 obo:IAO_0000115 "Seizure associated with a presumed or proven infection (excluding infection of the central nervous system) or inflammatory state without an alternative precipitant such as metabolic derangement, and regardless of the presence or absence of a fever." ; dcterms:creator ; a owl:Class ; rdfs:comment "This includes seizures in the context of febrile or afebrile infection." ; rdfs:label "Infection-related seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0032893 obo:IAO_0000115 "Afebrile (less than 38.0 degrees Celcius), brief, and generalized seizures accompanying gastroenteritis without an alternative cause." ; dcterms:creator ; a owl:Class ; rdfs:comment "Most typically these seizures have been studied in children between the ages of six months and three years. They often occur in clusters." ; rdfs:label "Gastroenteritis-related afebrile seizure" ; rdfs:subClassOf obo:HP_0032892 . obo:HP_0032894 obo:IAO_0000115 "Any form of seizure occurring at the time of a fever (temperature at or above 38.0 degrees Celcius) without infection of the central nervous system, and without an alternative cause such as severe metabolic derangement, occurring at any age." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fever induced seizure" ; a owl:Class ; rdfs:comment "Typically febrile seizures are limited to the age range of 3 months to 6 years and not accompanied or preceded by afebrile seizures; in this case febrile seizures are not considered indicative of epilepsy. When febrile seizures occur prior to the age of 3 months, or continue beyond the 6th birthday, or when a person has both febrile seizures and afebrile generalized tonic-clonic seizures then a diagnosis of Febrile Seizures Plus (an epilepsy syndrome) may be made." ; rdfs:label "Seizure precipitated by febrile infection" ; rdfs:subClassOf obo:HP_0032892 . obo:HP_0032895 obo:IAO_0000115 "Any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38.0 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in people beyond the typical arrange of 3 months-6 years with no prior history of afebrile seizure." ; dcterms:creator ; a owl:Class ; rdfs:comment "Some but not all people with the epilepsy syndrome of Febrile Seizures Plus have these types of seizures." ; rdfs:label "Febrile seizure outside the age of 3 months to 6 years" ; rdfs:subClassOf obo:HP_0032894 . obo:HP_0032896 obo:IAO_0000115 "Seizure precipitated by listening to music or other complex sounds." ; dcterms:creator ; a owl:Class ; rdfs:label "Music-induced seizure" ; rdfs:subClassOf obo:HP_0020207 . obo:HP_0032897 obo:IAO_0000115 "A focal sensory seizure with gustatory features in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sensory seizure with gustatory features" ; rdfs:subClassOf obo:HP_0011160, obo:HP_0032787 . obo:HP_0032898 obo:IAO_0000115 "A focal seizure characterized at onset by coordinated motor activity. This often resembles a voluntary movement and may consist of an inappropriate continuation of preictal motor activity." ; dcterms:creator ; a owl:Class ; rdfs:comment "An automatism is a coordinated, repetitive motor activity, often resembling a voluntary movement, but undertaken without volition." ; rdfs:label "Focal automatism seizure" ; rdfs:subClassOf obo:HP_0011153 . obo:HP_0032899 obo:IAO_0000115 "A type of focal automatism seizure characterized by orofacial automatisms at onset." ; dcterms:creator ; a owl:Class ; rdfs:comment "These may include involuntary lip smacking, lip pursing, chewing, swallowing, clicking sounds, or eye-blinking." ; rdfs:label "Focal orofacial automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032900 obo:IAO_0000115 "A type of focal automatism seizure characterized by manual automatisms at onset." ; dcterms:creator ; a owl:Class ; rdfs:comment "These may include involuntary unilateral or bilateral, fumbling, tapping, manipulating, or exploratory movements of the hands." ; rdfs:label "Focal manual automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032901 obo:IAO_0000115 "A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." ; dcterms:creator ; a owl:Class ; rdfs:comment "These may include pacing, walking, or running." ; rdfs:label "Focal pedal automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032902 obo:IAO_0000115 "A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal perseverative automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032903 obo:IAO_0000115 "A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal vocal automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032904 obo:IAO_0000115 "A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal verbal automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032905 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary sexual behavior at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal sexual automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032906 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary head nodding at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal head nodding automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032907 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary undressing at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal undressing automatism seizure" ; rdfs:subClassOf obo:HP_0032898 . obo:HP_0032908 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary undressing at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware undressing automatism seizure" ; rdfs:subClassOf obo:HP_0032907, obo:HP_0032910 . obo:HP_0032909 obo:IAO_0000115 "A focal seizure with automatism in which awareness is partially or fully impaired at some point during the seizure." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness automatism seizure" ; rdfs:subClassOf obo:HP_0032712, obo:HP_0032898 . obo:HP_0032910 obo:IAO_0000115 "A type of focal automatism seizure during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware automatism seizure" ; rdfs:subClassOf obo:HP_0020217, obo:HP_0032898 . obo:HP_0032911 obo:IAO_0000115 "A type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware orofacial automatism seizure" ; rdfs:subClassOf obo:HP_0032899, obo:HP_0032910 . obo:HP_0032912 obo:IAO_0000115 "A type of focal automatism seizure characterized by manual automatisms at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware manual automatism seizure" ; rdfs:subClassOf obo:HP_0032900, obo:HP_0032910 . obo:HP_0032913 obo:IAO_0000115 "A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware pedal automatism seizure" ; rdfs:subClassOf obo:HP_0032901, obo:HP_0032910 . obo:HP_0032914 obo:IAO_0000115 "A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware perseverative automatism seizure" ; rdfs:subClassOf obo:HP_0032902, obo:HP_0032910 . obo:HP_0032915 obo:IAO_0000115 "A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware vocal automatism seizure" ; rdfs:subClassOf obo:HP_0032903, obo:HP_0032910 . obo:HP_0032916 obo:IAO_0000115 "A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware verbal automatism seizure" ; rdfs:subClassOf obo:HP_0032904, obo:HP_0032910 . obo:HP_0032917 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary sexual behavior at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware sexual automatism seizure" ; rdfs:subClassOf obo:HP_0032905, obo:HP_0032910 . obo:HP_0032918 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by orofacial automatisms at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness orofacial automatism seizure" ; rdfs:subClassOf obo:HP_0032899, obo:HP_0032909 . obo:HP_0032919 obo:IAO_0000115 "A type of focal automatism seizure characterized by involuntary head nodding at onset and during which awareness is fully retained throughout." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal aware head nodding automatism seizure" ; rdfs:subClassOf obo:HP_0032906, obo:HP_0032910 . obo:HP_0032920 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by manual automatisms at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness manual automatism seizure" ; rdfs:subClassOf obo:HP_0032900, obo:HP_0032909 . obo:HP_0032921 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness pedal automatism seizure" ; rdfs:subClassOf obo:HP_0032901, obo:HP_0032909 . obo:HP_0032922 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by inappropriate continuation of pre-seizure movement or behavior at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness perseverative automatism seizure" ; rdfs:subClassOf obo:HP_0032902, obo:HP_0032909 . obo:HP_0032923 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness vocal automatism seizure" ; rdfs:subClassOf obo:HP_0032903, obo:HP_0032909 . obo:HP_0032924 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive words, phrases, or brief sentences at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness verbal automatism seizure" ; rdfs:subClassOf obo:HP_0032904, obo:HP_0032909 . obo:HP_0032925 obo:IAO_0000115 "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by involuntary sexual behavior at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness sexual automatism seizure" ; rdfs:subClassOf obo:HP_0032905, obo:HP_0032909 . obo:HP_0032926 obo:IAO_0000115 "A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary head nodding at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness head nodding automatism seizure" ; rdfs:subClassOf obo:HP_0032906, obo:HP_0032909 . obo:HP_0032927 obo:IAO_0000115 "A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary undressing at onset." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal impaired awareness undressing automatism seizure" ; rdfs:subClassOf obo:HP_0032907, obo:HP_0032909 . obo:HP_0032928 obo:IAO_0000115 "Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF neurofilament light chain" ; a owl:Class ; rdfs:label "Elevated CSF neurofilament light chain concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0032929 obo:IAO_0000115 "Any abnormal structure of a chondrocyte, which is a polymorphic cell that forms cartilage." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal chondrocyte morphology" ; rdfs:subClassOf obo:HP_0002763 . obo:HP_0032930 obo:IAO_0000115 "Concentric rings around the chondrocytes." ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 2 in PMID:8571951." ; rdfs:label "Lacunar halos around chondrocytes" ; rdfs:subClassOf obo:HP_0032929 . obo:HP_0032931 obo:IAO_0100001 "HP:0032756" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Focal impaired awareness cognitive seizure with impaired attention" ; owl:deprecated true . obo:HP_0032932 obo:IAO_0000115 "An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating pancreatic triacylglycerol lipase activity" ; a owl:Class ; rdfs:comment "Acute pancreatitis is the main reason for an increase in lipase, although a number of other conditions such as chronic pancreatitis, acute cholecystitis, and bowel obstruction can increase lipase activity. In acute pancreatitis, serum lipase levels usually rise within 4 to 8 hours, peak at 24 hours, and decrease to normal or near normal levels over the next 8 to 14 days. Serum lipase remains elevated for a longer period of time compared to the period of elevation of serum amylase after acute pancreatitis. A common threshold used is three times the normal limit." ; rdfs:label "Increased circulating pancreatic triacylglycerol lipase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0032933 obo:IAO_0000115 "An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist." ; dcterms:creator ; a owl:Class ; rdfs:label "Airway hyperresponsiveness" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0032934 obo:IAO_0000115 "A spontaneous cerebrospinal fluid leak (SCSFL) is a spontaneous and unexplained leak of the cerebrospinal fluid from the dura surrounding either the brain (cranial leak) or spine (spinal leak)." ; dcterms:creator ; a owl:Class ; rdfs:label "Spontaneous cerebrospinal fluid leak" ; rdfs:subClassOf obo:HP_0010651 . obo:HP_0032935 obo:IAO_0000115 "Grayish, polygonal pattern of opacities with intervening clear zones across the central cornea that resembles crocodile skin." ; dcterms:creator ; a owl:Class ; rdfs:label "Posterior crocodile shagreen of the cornea" ; rdfs:subClassOf obo:HP_0007881 . obo:HP_0032936 obo:IAO_0000115 "Unintentional reexperiencing a traumatic event comprising symptoms are usually sensory impressions and emotional responses from the trauma that appear to lack a time perspective and a context." ; dcterms:creator ; oboInOwl:hasExactSynonym "Re-experiencing symptom" ; a owl:Class ; rdfs:comment "Vivid intrusive memories, flashbacks, or nightmares, typically accompanied by strong and overwhelming emotions such as fear or horror, and strong physical sensations." ; rdfs:label "Intrusion symptom" ; rdfs:subClassOf obo:HP_0033676 . obo:HP_0032937 obo:IAO_0000115 "After suffering psychological trauma, people can repeatedly experience sensory-perceptual impressions of the event, which intrude involuntarily into consciousness. These intrusive memories typically take the form of visual images (e.g., pictures in the mind's eye), but can also include sounds, smells, tastes and bodily sensations, and come with a range of negative emotions associated with the hotspots in the trauma memory." ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent, involuntary and intrusive distressing memories" ; rdfs:subClassOf obo:HP_0032936 . obo:HP_0032938 obo:IAO_0000115 "Recurrent distressing dreams in which the content and/or affect of the dream are related to the traumatic event or events." ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent trauma-related distressing dreams" ; rdfs:subClassOf obo:HP_0032936 . obo:HP_0032939 obo:IAO_0000115 "Marked physiological reactions to internal or external cues that symbolize or resemble an aspect of the traumatic event(s)." ; dcterms:creator ; a owl:Class ; rdfs:label "Physiological reactivity to cues" ; rdfs:subClassOf obo:HP_0032936 . obo:HP_0032940 obo:IAO_0000115 "A disruption and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. Clinical presentations of dissociation may include a wide variety of symptoms, including experiences of depersonalization, derealisation, emotional numbing, flashbacks of traumatic events, absorption, amnesia, voice hearing, interruptions in awareness, and identity alteration." ; dcterms:creator ; a owl:Class ; rdfs:label "Dissociative reaction" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0032941 obo:IAO_0000115 "Intense or prolonged psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event or events." ; dcterms:creator ; a owl:Class ; rdfs:label "Intense psychological distress to cues" ; rdfs:subClassOf obo:HP_0032936 . obo:HP_0032942 obo:IAO_0000115 "Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s)." ; dcterms:creator ; a owl:Class ; rdfs:label "Avoidance of stimuli associated with traumatic event" ; rdfs:subClassOf obo:HP_0033676 . obo:HP_0032943 obo:IAO_0000115 "A deviation of urine pH from the normal range of 4.5 to 7.8." ; dcterms:creator ; a owl:Class ; rdfs:comment "Urine pH typically is 5 as a result of daily net acid excretion. The interpretation of the urine pH depends on the medical context." ; rdfs:label "Abnormal urine pH" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0032944 obo:IAO_0000115 "Urine pH of 8 or higher." ; dcterms:creator ; a owl:Class ; rdfs:label "Alkaline urine" ; rdfs:subClassOf obo:HP_0032943 . obo:HP_0032945 obo:IAO_0000115 "Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial inflammation" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032946 obo:IAO_0000115 "Histopathological findings of inflammation of the renal interstitium involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal cortical interstitial inflammation" ; rdfs:subClassOf obo:HP_0032945 . obo:HP_0032947 obo:IAO_0000115 "Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal medullary interstitial inflammation" ; rdfs:subClassOf obo:HP_0032945 . obo:HP_0032948 obo:IAO_0000115 "The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic." ; dcterms:creator ; a owl:Class ; rdfs:comment "Tubular atrophy (TA) is defined as loss of specialized transport and metabolic capacity and typically manifested by small tubules with cells with pale cytoplasm or dilated, thin tubules. TA is usually associated with IF, but probably has distinct mechanisms related to blood flow, glomerular filtration rate (GFR) or tubular continuity loss. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation)." ; rdfs:label "Renal interstitial fibrosis" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0032949 obo:IAO_0000115 "The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal interstitial calcium phosphate deposits" ; rdfs:subClassOf obo:HP_0032644 . obo:HP_0032950 obo:IAO_0000115 "Abnormal structure or form of the lumen (opening) of kidney tubules." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal renal tubular luminal morphology" ; a owl:Class ; rdfs:label "Abnormal renal tubular lumen morphology" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032951 obo:IAO_0000115 "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular viral cytopathic changes" ; rdfs:subClassOf obo:HP_0000091 . obo:HP_0032952 obo:IAO_0000115 "A type of renal tubular atrophy in which the tubules show thick tubular basement membranes lined by small cuboidal or flat cells. Generally accompanied by fibrosis." ; dcterms:creator ; oboInOwl:hasExactSynonym "Common-type renal tubular atrophy" ; a owl:Class ; rdfs:label "Usual-type tubular atrophy" ; rdfs:subClassOf obo:HP_0000092 . obo:HP_0032953 obo:IAO_0000115 "Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular cytomegalovirus inclusions" ; rdfs:subClassOf obo:HP_0032951 . obo:HP_0032954 obo:IAO_0000115 "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular adenovirus inclusions" ; rdfs:subClassOf obo:HP_0032951 . obo:HP_0032955 obo:IAO_0000115 "Renal ltubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection." ; dcterms:creator ; a owl:Class ; rdfs:comment "The inclusions are generally accompanied by a patchy pleomorphic interstitial infiltrate with lymphocytes, plasma cells, and occasional neutrophils with associated interstitial edema, tubulitis, and tubular injury. Infected tubular epithelial cells have enlarged nuclei with amorphous inclusions. Polyomavirus infection occurs in the transplanted allograft kidney and in the native kidney of immunosuppressed patients, and is usually related to BK virus (80%), JC virus (10%-20%), and less frequently simian virus 40 (SV40)." ; rdfs:label "Renal tubular polyoma virus inclusions" ; rdfs:subClassOf obo:HP_0032951 . obo:HP_0032956 obo:IAO_0000115 "Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis." ; dcterms:creator ; a owl:Class ; rdfs:label "Renal tubular herpes simplex virus inclusions" ; rdfs:subClassOf obo:HP_0032951 . obo:HP_0032957 obo:IAO_0000115 "The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria." ; dcterms:creator ; oboInOwl:hasExactSynonym "Acanthocyturia" ; a owl:Class ; rdfs:label "Dysmorphic hematuria" ; rdfs:subClassOf obo:HP_0000790 . obo:HP_0032958 obo:IAO_0000115 "The presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets." ; dcterms:creator ; a owl:Class ; rdfs:label "Urinary oval fat bodies" ; rdfs:subClassOf obo:HP_0012614 . obo:HP_0032959 obo:IAO_0000115 "Birefringent calcium- and oxalate-containing casts located within the tubuli of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular calcium oxalate casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032960 obo:IAO_0000115 "Purple and finely granular/laminated calcium- and phosphate-containing casts located within the tubuli of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:label "Intratubular calcium phosphate casts" ; rdfs:subClassOf obo:HP_0032623 . obo:HP_0032961 obo:IAO_0000115 "Magnesium ammonium phosphate crystals in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Struvite urinary crystals" ; a owl:Class ; rdfs:label "Magnesium ammonium phosphate crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0032962 obo:IAO_0000115 "Dilated renal tubules (over twice the diameter of a normal proximal tubule) containing eosinophilic amorphous material. This feature is generally accompanied by scalloping of the cast profile. The epithelium lining the microcyst is generally flattened and does not reveal brush border." ; dcterms:creator ; a owl:Class ; rdfs:label "Tubular microcystic change" ; rdfs:subClassOf obo:HP_0032950 . obo:HP_0032963 obo:IAO_0000115 "A renal cyst characterized by epithelium lined space (squamous/columnar) with septations." ; dcterms:creator ; a owl:Class ; rdfs:label "Complex renal cyst" ; rdfs:subClassOf obo:HP_0000107 . obo:HP_0032964 obo:IAO_0000115 "The presence of uric acid crystals in the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "Uric acid crystals are very pleiomorphic, but the rhomboidal shape is the most frequent. Distinctive morphological features are the amber colour and the constant polychromatic birefringence. These crystals can be found both in normal subjects as well as in stone formers. Moreover, they can be found, alone or with amorphous urates in patients with increased purine metabolism." ; rdfs:label "Uric acid crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0032965 obo:IAO_0000115 "Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation. It is rarely recognized radiographically in adults and is infrequently seen on CT scans. It appears as perivascular lucent or low attenuating halos and small cysts." ; dcterms:creator ; a owl:Class ; rdfs:label "Interstitial emphysema" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0032966 obo:IAO_0000115 "A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones." ; dcterms:creator ; oboInOwl:hasExactSynonym "Centriacinar emphysema" ; a owl:Class ; rdfs:label "Centrilobular emphysema" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0032967 obo:IAO_0000115 "Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis." ; dcterms:creator ; a owl:Class ; rdfs:label "Panacinar emphysema" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0032968 obo:IAO_0000115 "Abnormal retention of gas within a lung or part of a lung, as a result of airway obstuction of abnormalities in lung compliance. In the classic presentation, the lung will appear normal at inspiration, but on exhalation, the diseased portions of the lung which have lost connective tissue recoil will remain lucent while the healthy portions of the lung will become more dense due to atelectasis. This helps distinguish it from mosaic attenuation due to patchy fibrosis, as occurs with nonspecific interstitial pneumonia, and in early usual interstitial pneumonitis (the hallmark imaging diagnosis of interstitial lung disease) in which there is no change with inspiration and expiration." ; dcterms:creator ; a owl:Class ; rdfs:comment "The extent of air trapping present on expiratory scans can be measured using a semiquantitative scoring system, which estimates the percentage of lung that appears abnormal on each scan. Such systems have the advantage of being simple, quick, and easy to perform at the time of image interpretation. Furthermore, in one study, a simple 5-point scoring system was found to be associated with better interobserver agreement than a more detailed scoring system." ; rdfs:label "Expiratory air trapping" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0032969 obo:IAO_0000115 "Distortion of the bronchial airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchial dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as cysts." ; dcterms:creator ; a owl:Class ; rdfs:comment "The juxtaposition of numerous cystic airways may make the distinction from pure fibrotic honeycombing difficult. Also the differentation to peribronchovascular interstitial thickening can be difficult, but they can be distinguished on the basis of symptoms or pulmonary function abnormalities. In addition, patients with traction bronchiectasis have abnormal thick-walled and dilated bronchi that often appear much larger than the adjacent pulmonary artery braches, with a bronchoarterial ratio exceeding 1. This results in the appearance of an additional finding, the signet ring sign (HP:0032175)." ; rdfs:label "Traction bronchiectasis" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0032970 dcterms:creator ; a owl:Class ; rdfs:comment "Distortion of the bronchiolar airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchiolar dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as microcysts." ; rdfs:label "Traction bronchiolectasis" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0032971 obo:IAO_0000115 "CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm." ; dcterms:creator ; oboInOwl:hasExactSynonym "CT halo sign" ; a owl:Class ; rdfs:label "Computed tomographic halo sign" ; rdfs:subClassOf obo:HP_0025179 . obo:HP_0032972 obo:IAO_0000115 "A nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases." ; dcterms:creator ; a owl:Class ; rdfs:label "Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT" ; rdfs:subClassOf obo:HP_0025392 . obo:HP_0032973 obo:IAO_0000115 "Abnormal type or counts of nucleated immune cells and acellular components in bronchoalveolar lavage (BAL) fluid. BAL us performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. BAL is commonly used to inform the differential diagnosis of interstitial lung disease or to monitor therapeutic interventions." ; dcterms:creator ; a owl:Class ; rdfs:comment "Red blood cells in the BAL fluid are noted (e.g. present in pulmonary hemorrhage syndromes), but not counted, Similarly epithelial cells are only noted, not included numerically into cell differential." ; rdfs:label "Abnormal bronchoalveolar lavage fluid morphology" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0032974 obo:IAO_0000115 "Deviation from the commonly in healthy people observe cellular distribution. Normal ranghes are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cell differential of broncho-alveolar fluid" ; a owl:Class ; rdfs:label "Abnormal cellular composition of bronchoalveolar fluid" ; rdfs:subClassOf obo:HP_0032973 . obo:HP_0032975 obo:IAO_0000115 "Any deviation from the normal concentration of protein in the bronchoalveolar fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal biochemical composition of broncho-alveolar fluid", "Abnormal level of proteins in the broncho-alveolar fluid" ; a owl:Class ; rdfs:label "Abnormal bronchoalveolar fluid protein level" ; rdfs:subClassOf obo:HP_0032973 . obo:HP_0032976 obo:IAO_0000115 "Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases." ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated bronchoalveolar lavage fluid lymphocyte proportion" ; rdfs:subClassOf obo:HP_0032974 . obo:HP_0032977 obo:IAO_0000115 "Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated level of neutrophils in broncho-alveolar lavage fluid" ; a owl:Class ; rdfs:label "Elevated bronchoalveolar lavage fluid neutrophil proportion" ; rdfs:subClassOf obo:HP_0032974 . obo:HP_0032978 obo:IAO_0000115 "Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions." ; dcterms:creator ; a owl:Class ; rdfs:label "Lipid-laden macrophages in bronchoalveolar fluid" ; rdfs:subClassOf obo:HP_0032984 . obo:HP_0032979 obo:IAO_0000115 "Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Accumulation of hemosiderin laden alveolar macrophages", "Siderophages in bronchoalveolar fluid" ; a owl:Class ; rdfs:comment "Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen." ; rdfs:label "Hemosiderin-laden macrophages in bronchoalveolar fluid" ; rdfs:subClassOf obo:HP_0032984 . obo:HP_0032980 obo:IAO_0000115 "Significantly decreased level or failed detection of surfactant protein C in broncho-alveolar lavage fluid. Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-C may result of surfactant metabolism dysfunction and is also observed in patients with other diffuse parenchymal lung diseaes, pathogenetically related to the alveolar surfactant region." ; dcterms:creator ; a owl:Class ; rdfs:label "Absent bronchoalveolar surfactant-protein C" ; rdfs:subClassOf obo:HP_0032975 . obo:HP_0032981 obo:IAO_0000115 "Significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid." ; dcterms:creator ; a owl:Class ; rdfs:comment "Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-B may result of surfactant metabolism dysfunction." ; rdfs:label "Absent bronchoalveolar dimeric surfactant-protein B" ; rdfs:subClassOf obo:HP_0032975 . obo:HP_0032982 obo:IAO_0100001 "HP:0006517" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Intraalveolar phospholipid accumulation" ; owl:deprecated true . obo:HP_0032983 obo:IAO_0000115 "CT finding of central ground-glass opacity surrounded by denser consolidation of crescentic shape (forming more than three-fourths of a circle) or complete ring of at least 2 mm in thicknes. A rare sign, it was initially reported to be specific for cryptogenic organizing pneumonia, but was subsequently described in patients with paracoccidioidomycosis." ; dcterms:creator ; oboInOwl:hasExactSynonym "Reversed halo sign" ; a owl:Class ; rdfs:label "Atoll sign" ; rdfs:subClassOf obo:HP_0025179 . obo:HP_0032984 obo:IAO_0000115 "Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal alveolar macrophage morphology" ; rdfs:subClassOf obo:HP_0032974 . obo:HP_0032985 obo:IAO_0000115 "Accumulation of inhaled, nondigestable particles in macrophages." ; dcterms:creator ; a owl:Class ; rdfs:comment "This can be recognized in May-Grunwald-Giemsa routine stains. Rarey and for special indications, BAL can be further analysed to identify and quantify dust exposure. X-ray microprobe analysis identified particles which related to the known exposures, superimposed on a background of other particles related to smoking (kaolinite and mica) or to the general environment (silicon, titanium, and iron). Inhaled dust can follow in fibrous tissue and scarring which follow in impaired lung function." ; rdfs:label "Dust particle inclusion in alveolar macrophages" ; rdfs:subClassOf obo:HP_0032984 . obo:HP_0032986 obo:IAO_0000115 "In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits." ; dcterms:creator ; a owl:Class ; rdfs:label "Smoker-inclusions in alveolar macrophages" ; rdfs:subClassOf obo:HP_0032984 . obo:HP_0032987 obo:IAO_0000115 "Usually, eosinophils make up less than 0.5% of all cells found in the broncho-alveloar lavage fluid. But in eosinophilic lung disease, the eosinophil cell proportion typically represents more than 25%. Comment: An elevated level of eosinophil cells are also a result of infections, or an allergic reaction or can be drug-induced." ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated bronchoalveolar lavage fluid eosinophil proportion" ; rdfs:subClassOf obo:HP_0032974 . obo:HP_0032988 obo:IAO_0000115 "The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes." ; dcterms:creator ; oboInOwl:hasExactSynonym "Head lag", "Headlag" ; a owl:Class ; rdfs:comment "During pull-to-sit, the normal response is for an infant to right the head and maintain it in line with the shoulders. Head lag is demonstrated when the head is not righted but lags posteriorly behind the trunk as a result of poor head and neck control." ; rdfs:label "Persistent head lag" ; rdfs:subClassOf obo:HP_0001270 . obo:HP_0032989 obo:IAO_0000115 "Delayed ahcievement of the ability to roll front to back and back to front." ; dcterms:creator ; a owl:Class ; rdfs:comment "Most infants can roll from the prone to supine position (front to back) at the age of 4 months. Most infants can roll from back to front at the age of 5 or 6 months." ; rdfs:label "Delayed ability to roll over" ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0032990 obo:IAO_0000115 "Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder." ; dcterms:creator ; oboInOwl:hasExactSynonym "Localised pulmonary haemorrhage" ; a owl:Class ; rdfs:label "Localized pulmonary hemorrhage" ; rdfs:subClassOf obo:HP_0040223 . obo:HP_0032991 obo:IAO_0000115 "An abnormal form or number of the pulmonary fissures." ; dcterms:creator ; a owl:Class ; rdfs:comment "A fissure is the infolding of visceral pleura that separates one lobe or part of a lobe from another; thus, the interlobar fissures are produced by two layers of visceral pleura. The azygos fissure, unlike the other fissures, is formed by two layers each of visceral and parietal pleura. Supernumerary fissures usually separate segments rather than lobes. Supernumerary fissures usually separate segments rather than lobes." ; rdfs:label "Abnormal pulmonary fissure morphology" ; rdfs:subClassOf obo:HP_0002103, obo:HP_4000059 . obo:HP_0032992 obo:IAO_0000115 "An abnormal form or location of a pulmonary fissure." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary fissure architecture" ; rdfs:subClassOf obo:HP_0032991 . obo:HP_0032993 obo:IAO_0000115 "A deviation from the normal number of pulmonary fissures." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary fissure count" ; rdfs:subClassOf obo:HP_0032991 . obo:HP_0032994 obo:IAO_0000115 "Presence of a lung fissure that does not exist normally. Supernumerary fissures include the superior accessory fissure, the medial basal fissure, the left horizontal fissure, and the azygos fissure form supernumerary lobes." ; dcterms:creator ; oboInOwl:hasExactSynonym "increased pulmonary fissure count" ; a owl:Class ; rdfs:label "Supernumerary pulmonary fissure" ; rdfs:subClassOf obo:HP_0032993 . obo:HP_0032995 obo:IAO_0000115 "Lack of one or more of the normal pulmonary fissures." ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced pulmonary fissure count" ; a owl:Class ; rdfs:label "Decreased pulmonary fissure count" ; rdfs:subClassOf obo:HP_0032993 . obo:HP_0032996 obo:IAO_0000115 "Any deviation from the normal concentration of cystatin C in serum or plasma." ; dcterms:creator ; a owl:Class ; rdfs:comment "The cysteine protease inhibitor cystatin C is thought to be secreted by most cells and eliminated in the kidneys, so its concentration in plasma is diagnostic of kidney function." ; rdfs:label "Abnormal cystatin C level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0032997 obo:IAO_0000115 "A decreased concentration of cystatin C in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased cystatin C level" ; rdfs:subClassOf obo:HP_0032996 . obo:HP_0032998 obo:IAO_0000115 "A elevated concentration of cystatin C in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased cystatin C level" ; rdfs:subClassOf obo:HP_0032996 . obo:HP_0032999 obo:IAO_0000115 "Abnormally high concentration of fecal porphyrins in feces." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased faecal porphyrin" ; a owl:Class ; rdfs:label "Increased fecal porphyrin" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0033000 obo:IAO_0000115 "Narrowing of the larynx, commonly occuring during viral respiratory tract infections, in particular in children, leads to symptoms such as hoarseness, a barking cough, stridor, and sometimes dyspnea and respiratory failure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Croup", "Laryngitis", "Pseudocroup", "Spasmodic croup", "Viral croup" ; a owl:Class ; rdfs:label "Subglottic laryngitis" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0033001 obo:IAO_0000115 "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the larynx." ; dcterms:creator ; oboInOwl:hasExactSynonym "Laryngeal papillomas", "Laryngeal papillomatosis" ; a owl:Class ; rdfs:label "Laryngeal papilloma" ; rdfs:subClassOf obo:HP_0100605 . obo:HP_0033002 obo:IAO_0000115 "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on a bronchus." ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchial papilloma" ; rdfs:subClassOf obo:HP_0030077 . obo:HP_0033003 obo:IAO_0000115 "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the trachea." ; dcterms:creator ; a owl:Class ; rdfs:label "Tracheal papilloma" ; rdfs:subClassOf obo:HP_0100551 . obo:HP_0033004 obo:IAO_0000115 "Multiple verrucous lesions on the skin of the palm. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by human papillomavirus (HPV)." ; dcterms:creator ; a owl:Class ; rdfs:label "Palmar warts" ; rdfs:subClassOf obo:HP_0040211 . obo:HP_0033005 obo:IAO_0000115 "Multiple verrucous lesions on the skin of the sole of the foot. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV)." ; dcterms:creator ; a owl:Class ; rdfs:label "Plantar warts" ; rdfs:subClassOf obo:HP_0100872 . obo:HP_0033006 obo:IAO_0000115 "Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation." ; dcterms:creator ; a owl:Class ; rdfs:label "Diffuse alveolar damage" ; rdfs:subClassOf obo:HP_0033137 . obo:HP_0033007 obo:IAO_0000115 "Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss." ; dcterms:creator ; a owl:Class ; rdfs:label "Architectural distortion of the lung" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0033008 obo:IAO_0000115 "Abnormally increased width of the Z-disk of the sarcomere, resulting from splitting or opening of the Z-disc (c.f., Figure 2 of PMID:28732005)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased Z-disk width", "Widened z-discs" ; a owl:Class ; rdfs:comment "The sarcomere is the basic contractile unit of striated muscle, and is composed of highly ordered thin (actin) filaments and thick (myosin) filaments. The cytoskeleton surrounding this elegant contractile molecular machinery is required as a scaffold to ensure efficiency of contraction. Longitudinally, sarcomeres are connected by Z-disk lattices that anchor thin filaments and transmit force along the myofibril. The strikingly regular lateral alignment of Z-disks between adjacent myofibrils ensures that during contraction myofibrils change length in unison, thus preventing damage to membrane systems that span between myofibrils and that are responsible for activating and relaxing the sarcomeres (T-tubules, sarcoplasmic reticulum)." ; rdfs:label "Increased Z-disc width" ; rdfs:subClassOf obo:HP_0020202 . obo:HP_0033009 obo:IAO_0000115 "Abnormally high concentration of coproporphyrin 1 in feces." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated faecal coproporphyrin 1", "Elevated fecal coproporphyrin 1", "Elevated stool coproporphyrin 1", "High faecal coproporphyrin 1", "High fecal coproporphyrin 1", "High stool coproporphyrin 1", "Increased faecal coproporphyrin 1" ; a owl:Class ; rdfs:label "Increased fecal coproporphyrin 1" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0033010 obo:IAO_0000115 "Abnormally high concentration of coproporphyrin 3 in feces" ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated faecal coproporphyrin 3", "Elevated fecal coproporphyrin 3", "Elevated stool coproporphyrin 3", "High faecal coproporphyrin 3", "High fecal coproporphyrin 3", "High stool coproporphyrin 3", "Increased faecal coproporphyrin 3" ; a owl:Class ; rdfs:label "Increased fecal coproporphyrin 3" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0033011 obo:IAO_0000115 "Extreme width of the skull in the occipital region, with anterior narrowing and prognathism." ; dcterms:creator ; a owl:Class ; rdfs:label "Platystencephaly" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0033012 obo:IAO_0000115 "Any deviation from the normal concentration of a metabolite in saliva." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal salivary metabolite concentration" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0033013 obo:IAO_0000115 "Any deviation from the normal concentration of cortisol in saliva." ; dcterms:creator ; a owl:Class ; rdfs:comment "Literature suggests that saliva may provide a more sensitive measure of cortisol than serum or plasma." ; rdfs:label "Abnormal salivary cortisol level" ; rdfs:subClassOf obo:HP_0033012 . obo:HP_0033014 obo:IAO_0000115 "Abnormally reduced concentration of cortisol in saliva." ; dcterms:creator ; a owl:Class ; rdfs:comment "Literature suggests that saliva may provide a more sensitive measure of cortisol than serum or plasma." ; rdfs:label "Decreased salivary cortisol level" ; rdfs:subClassOf obo:HP_0033013 . obo:HP_0033015 obo:IAO_0000115 "Abnormally elevated concentration of cortisol in saliva." ; dcterms:creator ; a owl:Class ; rdfs:comment "Literature suggests that saliva may provide a more sensitive measure of cortisol than serum or plasma." ; rdfs:label "Increased salivary cortisol level" ; rdfs:subClassOf obo:HP_0033013 . obo:HP_0033016 obo:IAO_0000115 "A lasting reduction beneath the normal level of total immunoglobulin D (IgD) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgM in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating IgD" ; rdfs:subClassOf obo:HP_0410245 . obo:HP_0033017 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin D (IgD) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgD in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgD" ; rdfs:subClassOf obo:HP_0410245 . obo:HP_0033018 obo:IAO_0000115 "A lasting absence of immunoglobulin D (IgD) in the blood, whereby at most trace quantities of IgD can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgM in blood" ; a owl:Class ; rdfs:label "Chronic absent circulating IgD" ; rdfs:subClassOf obo:HP_0410245 . obo:HP_0033019 obo:IAO_0000115 "A neoplasm that affects the male reproductive system." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3054" ; a owl:Class ; rdfs:label "Male reproductive system neoplasm" ; rdfs:subClassOf obo:HP_0010787 . obo:HP_0033020 obo:IAO_0000115 "A neoplasm that affects the female reproductive system." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3053" ; a owl:Class ; rdfs:label "Female reproductive system neoplasm" ; rdfs:subClassOf obo:HP_0010787 . obo:HP_0033021 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin E (IgE) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgE in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgE" ; rdfs:subClassOf obo:HP_0005479 . obo:HP_0033022 obo:IAO_0000115 "A lasting reduction beneath the normal level of total immunoglobulin E (IgE) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgE in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating IgE" ; rdfs:subClassOf obo:HP_0005479 . obo:HP_0033023 obo:IAO_0000115 "A lasting absence of immunoglobulin E (IgE) in the blood circulation, whereby at most trace quantities of IgE can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgE in blood" ; a owl:Class ; rdfs:label "Chronic absent circulating IgE" ; rdfs:subClassOf obo:HP_0005479 . obo:HP_0033024 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin A (IgA) in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:label "Transient decreased circulating IgA" ; rdfs:subClassOf obo:HP_0002720 . obo:HP_0033025 obo:IAO_0000115 "A lasting absence of immunoglobulin G (IgG) in the blood, whereby at most trace quantities of IgG can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent total IgG in blood" ; a owl:Class ; rdfs:label "Chronic absent circulating total IgG" ; rdfs:subClassOf obo:HP_0032132 . obo:HP_0033026 obo:IAO_0000115 "A small circumscribed whitish change in the color of the oral mucosa that is neither elevated nor depressed." ; dcterms:creator ; a owl:Class ; rdfs:label "White oral mucosal macule" ; rdfs:subClassOf obo:HP_0100669 . obo:HP_0033027 obo:IAO_0000115 "A pebbly orange appearance of the fundus that is said to resemble the skin of an orange." ; dcterms:creator ; a owl:Class ; rdfs:comment "Retinal peau d'orange is a common finding in pseudoxanthoma elasticum." ; rdfs:label "Retinal peau d'orange" ; rdfs:subClassOf obo:HP_0000479 . obo:HP_0033028 obo:IAO_0000115 "The presence autoantibodies in the serum that react to proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-RNP-antibodies", "Anti-U1-RNP antibody positivity" ; oboInOwl:hasNarrowSynonym "Anti-Scl-34 antibody positivity", "Anti-U3 ribonucleoprotein antibody positivity" ; a owl:Class ; rdfs:comment "High titers of anti-RNP antibodies are diagnostic of mixed connective tissue disorder (MCTD). Anti-RNP antibodies can also be found in patients with systemic lupus erythematosus." ; rdfs:label "Anti-U1 ribonucleoprotein antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0033029 obo:IAO_0100001 "HP:0034152" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Anti-Jo-1 antibody positivity" ; owl:deprecated true . obo:HP_0033030 obo:IAO_0000115 "The presence of autoantibodies in the serum that react to the glomerular basement membrane." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-GBM-antibody positivity" ; a owl:Class ; rdfs:comment "Anti-GBM-antibodies are found in Goodpasture syndrome. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage)." ; rdfs:label "Anti-glomerular basement membrane-antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033031 obo:IAO_0000115 "An extreme elevation of core body temperature above normal defined as a rectal temperature of 41.1 degrees Celsius (106 degrees Fahrenheit)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyperpyrexia is considered a medical emergency and typically results in referral for emergency care." ; rdfs:label "Hyperpyrexia" ; rdfs:subClassOf obo:HP_0001945 . obo:HP_0033032 obo:IAO_0000115 "Applies to a sign or symptom that is induced by an abusive adult (usually a parent)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Munchausen syndrome by proxy" ; a owl:Class ; rdfs:comment "Munchausen syndrome by proxy is not a pediatric condition, but the outward manifestation of an adult psychiatric disorder." ; rdfs:label "Triggered by an abusive adult" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0033033 obo:IAO_0000115 "The presence of autoantibodies in the serum that react to Anti-MDA5 (Anti-melanoma differentiation-associated proteine 5)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-melanoma differentiation-associated protein 5 antibodies" ; a owl:Class ; rdfs:comment "Anti-MDA5 antibodies are myositis-specific autoantibodies, that are specific for clinically amyopathic dermatomyositis (CADM), an uncommon presentation of idiopathic inflammatory myositis, which is associated with rapidly progressive interstitial lung disease." ; rdfs:label "Anti-MDA5 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033034 obo:IAO_0000115 "The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen." ; dcterms:creator ; a owl:Class ; rdfs:comment "ACPAs are the major autoantibodies in rheumatoid arthritis and are highly specific. They are useful in the diagnosis and in the prediction oft he course and outcome of rheumatoid arthritis." ; rdfs:label "Anti-citrullinated protein antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033035 obo:IAO_0000115 "Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal neurilemmal cell morphology", "Abnormal neurilemmocyte morphology" ; a owl:Class ; rdfs:label "Abnormal Schwann cell morphology" ; rdfs:subClassOf obo:HP_0100705 . obo:HP_0033036 obo:IAO_0000115 "Reduced level of nasal nitric oxide (nNO). Current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for nNO measurements recommend air aspiration via a nasal probe while the subject exhales through the mouth against resistance in order to maintain velum closure." ; dcterms:creator ; oboInOwl:hasExactSynonym "Low nasal nitric oxide level" ; a owl:Class ; rdfs:comment "Nasal nitric oxide (nNO) is measurable in nasal air and found to be low in cystic fibrosis and very low in primary ciliary dyskinesia." ; rdfs:label "Decreased nasal nitric oxide" ; rdfs:subClassOf obo:HP_0002795 . obo:HP_0033037 dcterms:creator ; oboInOwl:hasExactSynonym "Migratory polyarthritis" ; a owl:Class ; rdfs:comment "A form of arthritis characterized by gradual involvement of several joints, with involvement of some joints occurring following partial or full resolution of arthritis in joints with an earlier onset." ; rdfs:label "Migratory arthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0033038 obo:IAO_0000115 "The presence of autoantibodies in the serum that react to RNA-polymerase III." ; dcterms:creator ; a owl:Class ; rdfs:comment "Anti-RNA-polymerase III-autoantibodies can be detected in patients with systemic sclerosis." ; rdfs:label "Anti-RNA-polymerase-III-autoantibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033039 obo:IAO_0000115 "The presence of high titers of antigen-precipitating IgG in the serum." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of antigen-precipitating IgG antibodies" ; a owl:Class ; rdfs:comment "Sensitization to inhaled antigens may cause high titers of antigen-precipitating IgGs. Precipitins support the diagnosis of hypersensitivity pneumonitis, also known as extrinsic allergic, in symptomatic individuals. They may also be found in asymptomatic individuals, indicating exposure to a certain antigen. Major antigens causing hypersensitivity pneumonitis are mushrooms, fungi, yeasts, bird proteins, certains chemicals, bacteria or mycobacteria." ; rdfs:label "Increased circulating precipitin level" ; rdfs:subClassOf obo:HP_0003237 . obo:HP_0033040 obo:IAO_0000115 "The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Smith autoantibody" ; a owl:Class ; rdfs:comment "Anti-Sm-autoantibodies are highly specific for systemic lupus erythematosus (SLE)." ; rdfs:label "Anti-Sm antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0033041 obo:IAO_0000115 "Excessive or uncontrolled release of proinflammatory cytokines." ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypercytokinemia" ; a owl:Class ; rdfs:comment "Cytokines are a diverse group of small proteins that are secreted by cells for the purpose of intercellular signaling and communication. Specific cytokines have autocrine, paracrine, and/or endocrine activity and, through receptor binding, can elicit a variety of responses, depending upon the cytokine and the target cell. Among the many functions of cytokines are the control of cell proliferation and differentiation and the regulation of angiogenesis and immune and inflammatory responses. Inflammation associated with a cytokine storm begins at a local site and spreads throughout the body via the systemic circulation. Rubor (redness), tumor (swelling or edema), calor (heat), dolor (pain), and functio laesa (loss of function) are the hallmarks of acute inflammation. While the general concept of an excessive or uncontrolled release of proinflammatory cytokines is well known, a precise definition of what constitutes a cytokine storm is lacking. The first use of cytokine storm appears to be in an article published in 1993 on graft-versus-host disease. Cytokine storm has subsequently been described in patients infected by cytomegalovirus, Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis, group A streptococcus, influenza virus, variola virus, severe acute respiratory syndrome coronavirus (SARS-CoV),avian H5N1 influenza virus, and SARS-CoV-2" ; rdfs:label "Cytokine storm" ; rdfs:subClassOf obo:HP_0011113 . obo:HP_0033042 obo:IAO_0000115 "Any structural anomaly of the fetal part of the placenta, which is known as the chorion." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal chorion morphology" ; rdfs:subClassOf obo:HP_0100767 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003124 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033043 obo:IAO_0000115 "Swelling of the chorionic villi owing to fluid accumulation." ; dcterms:creator ; a owl:Class ; rdfs:label "Edematous chorionic villi" ; rdfs:subClassOf obo:HP_0033042 . obo:HP_0033044 obo:IAO_0000115 "Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones." ; dcterms:creator ; oboInOwl:hasExactSynonym "Regression of motor skills" ; a owl:Class ; rdfs:label "Motor regression" ; rdfs:subClassOf obo:HP_0002376 . obo:HP_0033045 obo:IAO_0000115 "A palpable swelling in both feet and ankles caused by an increase in interstitial fluid volume (excess fluid)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Bipedal oedema" ; a owl:Class ; rdfs:label "Bipedal edema" ; rdfs:subClassOf obo:HP_0010741 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000618 ] ) ] ] . obo:HP_0033046 obo:IAO_0000115 "Basophilic intracytoplasmic inclusions in macrophages. The inclusions have a small, round laminated appearance. Electron microscopy of Michaelis-Gutmann bodies exhibits partially digested bacteria." ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Malakoplakia" ; a owl:Class ; rdfs:comment "Malakoplakia is a rare chronic inflammation that is characterized microscopically by the accumulation of tissue macrophages containing unique intracytoplasmic calcified inclusion bodies, known as Michaelis-Gutmann bodies." ; rdfs:label "Michaelis-Gutmann bodies" ; rdfs:subClassOf obo:HP_0004311 . obo:HP_0033047 obo:IAO_0000115 "Body ache is a complaint that is often used to denote vague symptoms of mild fatigue, lethargy, or dull aches. We will define it here to mean a dull and poorly localizable pain that is described by the affected individual to affect multiple joints or body parts or even the entire body." ; dcterms:creator ; a owl:Class ; rdfs:label "Body ache" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033048 obo:IAO_0000115 "Hypointence (dark) appearance of the substantia nigra inmagnetic resonance imaging using susceptibility weighted imaging (SWI)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Low signal intensity in the substantia nigra on susceptibility-weighted imaging (SWI)" ; a owl:Class ; rdfs:comment "Susceptibility-weighted imaging (SWI) is a relatively new magnetic resonance (MR) technique that exploits the magnetic susceptibility differences of various tissues, such as blood, iron and calcification, as a new source of contrast enhancement. Low SWI signal intensity may suggest deposition of paramagnetic material." ; rdfs:label "Substantia nigra hypointensity on susceptibility-weighted imaging" ; rdfs:subClassOf obo:HP_0045007 . obo:HP_0033049 obo:IAO_0000115 "Hypointence (dark) appearance of the globus pallidus inmagnetic resonance imaging using susceptibility weighted imaging (SWI)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Susceptibility-weighted imaging (SWI) is a relatively new magnetic resonance (MR) technique that exploits the magnetic susceptibility differences of various tissues, such as blood, iron and calcification, as a new source of contrast enhancement. Low SWI signal intensity may suggest deposition of paramagnetic material." ; rdfs:label "Globus pallidus hypointensity on susceptibility-weighted imaging" ; rdfs:subClassOf obo:HP_0002453 . obo:HP_0033050 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat." ; dcterms:creator ; oboInOwl:hasExactSynonym "Pharyngodynia", "Sore throat", "Throat discomfort", "Throat pain" ; a owl:Class ; rdfs:label "Pharyngalgia" ; rdfs:subClassOf obo:HP_0012531, obo:HP_0033152 . obo:HP_0033051 obo:IAO_0000115 "A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia." ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired executive functioning" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0033052 obo:IAO_0000115 "Psychogenic non-epileptic seizures (PNES) are an important cause of apparently treatment-resistant epilepsy and remain a major diagnostic challenge in epileptology. The two main PNES groups are panic disorder (also occurring as a reaction in people with epilepsy) and dissociative disorder (pseudoseizure), often developing inpatients with no history of epilepsy. The main markers distinguishing PNES from epileptic seizures are (i) the way the patient tells the story (not focusing on the seizure symptoms, avoidance of the word seizure, etc); (ii) that they are prolonged (many minutes); (iii) associated with hyperventilation and eyes closed; and that they present as treatment-resistant epilepsy despite an often normal intellect and brain imaging." ; dcterms:creator ; a owl:Class ; rdfs:comment "Individuals with PNES may bite their tongue (though usually the front not the side), may injure themselves (though usually cuts, carpet burns or wrist injury from falling on to an out-stretched arm) and may report seizures from sleep (the night time being a vulnerable time for panic symptoms and likely to be awake at the onset)." ; rdfs:label "Psychogenic non-epileptic seizure" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0033053 obo:IAO_0000115 "Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges." ; dcterms:creator ; a owl:Class ; rdfs:label "Pseudoseizure" ; rdfs:subClassOf obo:HP_0033052 . obo:HP_0033054 obo:IAO_0000115 "A tremor-like cortical myoclonus. The tremulous movements are in fact small, high-frequency myoclonic jerks, induced by posture or action. They can be mild, but can also be more incapacitating. When present in the lower limbs, these may lead to gait disorders and even drop attacks. These tremor-like movements during action can be mistaken for essential tremor or epileptic seizures." ; dcterms:creator ; a owl:Class ; rdfs:label "Myoclonic tremor" ; rdfs:subClassOf obo:HP_0040148 . obo:HP_0033055 obo:IAO_0000115 "Impaired ability to anticipate future events, implement instructions or goals, and develop appropriate steps ahead of time in order to carry out a task or activity." ; dcterms:creator ; oboInOwl:hasExactSynonym "Ineffective planning" ; a owl:Class ; rdfs:label "Impaired ability to plan" ; rdfs:subClassOf obo:HP_0033051 . obo:HP_0033056 obo:IAO_0000115 "Impaired ability to bring order to information, actions, or materials to achieve a goal or to follow an established organized routine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired ability to organise" ; a owl:Class ; rdfs:label "Impaired ability to organize" ; rdfs:subClassOf obo:HP_0033051 . obo:HP_0033057 obo:IAO_0000115 "Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased serum terminal complement component" ; a owl:Class ; rdfs:label "Decreased circulating terminal complement component concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0033058 obo:IAO_0000115 "Concentration of the complement component C7 in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased serum complement C7" ; a owl:Class ; rdfs:comment "The complement component C7 is one of the five plasma proteins that interact sequentially to form the lytic membrane attack complex." ; rdfs:label "Decreased circulating complement C7 concentration" ; rdfs:subClassOf obo:HP_0033057 . obo:HP_0033059 obo:IAO_0000115 "Concentration of the complement component C6 in the blood circulation below the lower limit of normal." ; dcterms:creator ; a owl:Class ; rdfs:comment "Formation of the MAC is triggered by cleavage of C5 by a C5 convertase, which is followed by sequential interaction of C5b with C6, C7, C8, and C9. Assembly of the MAC on a cellular membrane results in its gradual insertion into the lipid bilayer and the formation of a transmembrane channel, which can kill susceptible cells or transmit activation or apoptotic signals." ; rdfs:label "Decreased circulating complement C6 concentration" ; rdfs:subClassOf obo:HP_0033057 . obo:HP_0033060 obo:IAO_0000115 "Concentration of the complement component C5 in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased serum complement C5" ; a owl:Class ; rdfs:comment "Human C5 complement is a plasma glycoprotein (MW:196 kDa) composed of two disulfide-bound polypeptidechains (C5alpha and C5beta). The C5 coding gene is located on chromosome 9q34.1 and spans a genomic region of 79 kb. Its open reading frame,composed of 41 exons, codes for C5alpha (exons 1-16) and C5beta (exons 17-41) and gives rise to a 6 kb mRNA translated into a pre-C5 protein which is processed into the mature, two-chain C5 form by the removal of the RPRR region." ; rdfs:label "Decreased circulating complement C5 concentration" ; rdfs:subClassOf obo:HP_0033057 . obo:HP_0033061 obo:IAO_0000115 "Elevated activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased factor IX activity" ; rdfs:subClassOf obo:HP_0033062 . obo:HP_0033062 obo:IAO_0000115 "Abnormal activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal factor IX activity" ; rdfs:subClassOf obo:HP_0010989 . obo:HP_0033063 obo:IAO_0000115 "A tendency to sleep less hours than usual while feeling well rested." ; dcterms:creator ; oboInOwl:hasExactSynonym "Short sleep" ; a owl:Class ; rdfs:label "Shortened sleep cycle" ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0033064 obo:IAO_0000115 "Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Fabry disease is a rare, progressive lysosomal disorder caused by mutations in the GLA gene. GLA encodes the homodimeric glycoprotein, alpha-galactosidase A, which acts in lysosomes to degrade globotriaosylceramide (GL-3) and its deacylated form, globotriaosylsphingosine (lyso-Gb3). In Fabry disease, the activity of alpha-galactosidase A is deficient or absent, leading to progressive accumulation of glycolipids, primarily GL-3 and lyso-Gb3, in the plasma and numerous cell types throughout the body." ; rdfs:label "Renal interstitial globotriaosylceramide inclusions" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0033065 obo:IAO_0000115 "The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol)." ; dcterms:creator ; a owl:Class ; rdfs:label "Mild albuminuria" ; rdfs:subClassOf obo:HP_0012592 . obo:HP_0033066 obo:IAO_0000115 "The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Heavy albuminuria" ; a owl:Class ; rdfs:label "Severe albuminuria" ; rdfs:subClassOf obo:HP_0012592 . obo:HP_0033067 dcterms:creator ; a owl:Class ; rdfs:comment "Cystine crystals precipitate as symmetrical hexagons, mostly aggregated, and are constantly birefringent. They are typical of patients with cystinuria, but to find them the urine pH must be lowered to 4.0 with glacial acetic acid and stored overnight at 4 degrees C." ; rdfs:label "Cystine crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0033068 obo:IAO_0000115 "A variety of drugs may occasionally cause transient crystalluria, in isolation or in conjunction with other urinary abnormalities. Overdose, dehydration, or hypoalbuminaemia, which increases the unbound drug which is ultrafiltrated by the glomerulus, are the factors usally favoring the precipitation of crystals within the tubular lumina. In some cases, medication-induced crystalluria has a distinct phenotypic appearance. For instance, Sulphadiazine crystals appear as strongly birefringent 'shocks of wheat' or 'shells' with an amber colour. Acyclovir crystals are birefringent and needle-shaped, and when present in abundance give to urine a silky and opalescent macroscopic appearance." ; dcterms:creator ; a owl:Class ; rdfs:label "Medication crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0033069 obo:IAO_0000115 "An increased number of IgG4+ plasma cells in the interstitial space of the kidney." ; dcterms:creator ; a owl:Class ; rdfs:comment "IgG4-related tubulointerstitial nephritis is characterized by an increased number of IgG4+ plasma cells per high-power field on renal biopsy in addition to either elevated serum IgG4 or evidence of extra renal IgG4-related disease." ; rdfs:label "Renal interstitial IgG4+ plasma cell infiltration" ; rdfs:subClassOf obo:HP_0032581 . obo:HP_0033070 obo:IAO_0000115 "Impaired ability to track awareness of the effect that one's behavior has on others and how it compares with standards or expectations for behavior." ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired self monitoring" ; rdfs:subClassOf obo:HP_0033051 . obo:HP_0033071 obo:IAO_0000115 "Impaired ability to keep track of one's problem-solving success or failure, and to identify and correct mistakes during performance of a goal." ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired task monitoring" ; rdfs:subClassOf obo:HP_0033051 . obo:HP_0033072 obo:IAO_0000115 "Anomalous physical appearance (color, cloudiness, clarity) or odor of urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal macroscopic urine appearance" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0033073 obo:IAO_0000115 "Intradermal urate crystal deposits appeared as small, superficial, pustule-like, whitish lesions. The lesions may be the focus of inflammatory episodes with increasing pain, swelling, and erythema of the intradermal tophi." ; dcterms:creator ; oboInOwl:hasExactSynonym "Urate tophi" ; a owl:Class ; rdfs:label "Urate tophus" ; rdfs:subClassOf obo:HP_0011356 . obo:HP_0033074 obo:IAO_0000115 "Amelioration of anemia upon treatment with a steroid medication." ; dcterms:creator ; oboInOwl:hasExactSynonym "Prednisone-responsive anaemia", "Prednisone-responsive anemia", "Steroid-responsive anaemia" ; a owl:Class ; rdfs:label "Steroid-responsive anemia" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0033075 obo:IAO_0000115 "A normal or elevated serum thyroid-stimulating hormone (TSH) level in the face of an elevation in circulating FT4 and/or FT3." ; dcterms:creator ; oboInOwl:hasExactSynonym "Inappropriately normal TSH" ; a owl:Class ; rdfs:comment "Inappropriately normal TSH may reflect a laboratory error, binding protein abnormalities leading to apparent elevation of FT4 (e.g. familial dysalbuminemic hyperthyroxinemia), antibody interference with measurements of FT4, FT3 or TSH, TSH-secreting pituitary tumor (TSHoma) or a syndrome of thyroid hormone resistance." ; rdfs:label "Inappropriately normal thyroid-stimulating hormone level" ; rdfs:subClassOf obo:HP_0031097 . obo:HP_0033076 obo:IAO_0000115 "A deviation from the normal concentration of free thyroxine (T4) in the blood circulation. Circulating T4 is almost entirely bound to specific transport proteins such as thyroxine-binding globulin (TBG) but it is the unbound (free) fraction that is able to enter tissues and exert effects." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating free T4 level", "Abnormal circulating free thyroxine level" ; a owl:Class ; rdfs:label "Abnormal circulating free T4 concentration" ; rdfs:subClassOf obo:HP_0031508 . obo:HP_0033077 obo:IAO_0000115 "An elevated concentration of free thyroxine (fT4) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating free T4 level" ; a owl:Class ; rdfs:label "Increased circulating free T4 concentration" ; rdfs:subClassOf obo:HP_0033076 . obo:HP_0033078 obo:IAO_0000115 "A reduced concentration of free thyroxine (fT4) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating free T4 level" ; a owl:Class ; rdfs:label "Decreased circulating free T4 concentration" ; rdfs:subClassOf obo:HP_0033076 . obo:HP_0033079 obo:IAO_0000115 "Absence or underdevelopment of the thyroid gland." ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the thyroid gland" ; rdfs:subClassOf obo:HP_0011772 . obo:HP_0033080 obo:IAO_0000115 "Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide synthesised by, stored within and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Following administration of exogenous TRH, a transient increase in serum TSH is expected. This term refers to an abnormal reponse in the TRH stimulation test." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal TSH response to TRH stimulation test" ; a owl:Class ; rdfs:label "Abnormal TSH response to thyrotrophin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0002926 . obo:HP_0033081 obo:IAO_0000115 "Failure to increase serum TSH levels in response to a TRH stimulation test." ; dcterms:creator ; a owl:Class ; rdfs:label "Absent TSH response to thyrotrophin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0033080 . obo:HP_0033082 obo:IAO_0000115 "A lower than normal TSH response to thyrotrophin-releasing hormone stimulation test." ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced TSH response to thyrotrophin-releasing hormone stimulation test" ; rdfs:subClassOf obo:HP_0033080 . obo:HP_0033083 obo:IAO_0000115 "An elevated level of farnesol in the blood circulation." ; dcterms:creator ; a owl:Class ; rdfs:comment "Farnesol is a farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1. Its concentration in the blood circulation is increased in inherited squalene synthase deficiency." ; rdfs:label "Increased circulating farnesol concentration" ; rdfs:subClassOf obo:HP_0003119 . obo:HP_0033084 obo:IAO_0000115 "Any deviation from a count of antral follicles that is normal for age. Antral follicles appear as small fluid-filled sacs that contain an immature egg. Antral follicle count can be measured (usually on day 2-5 of the menstrual cycle) by transvaginal ultrasound. The number of antral follicles may reflect ovarian reserve." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal antral follicle count" ; rdfs:subClassOf obo:HP_0031066 . obo:HP_0033085 obo:IAO_0000115 "A count of antral follicles that is lower than normal for age." ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced antral follicle count" ; rdfs:subClassOf obo:HP_0033084 . obo:HP_0033086 obo:IAO_0000115 "A count of antral follicles that is higher than normal for age." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased antral follicle count" ; rdfs:subClassOf obo:HP_0033084 . obo:HP_0033087 obo:IAO_0000115 "Fever that occurs at daily intervals." ; dcterms:creator ; a owl:Class ; rdfs:label "Quotidian fever" ; rdfs:subClassOf obo:HP_0032323 . obo:HP_0033088 obo:IAO_0000115 "Urine valine level above the normal range." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased valine in urine" ; a owl:Class ; rdfs:label "Valinuria" ; rdfs:subClassOf obo:HP_0033089 . obo:HP_0033089 obo:IAO_0000115 "An increased level of a branched chain family amino acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Branched-chain aminoaciduria" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033090 obo:IAO_0000115 "An elevated level of an aromatic amino acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased aromatic amino acid level in urine" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033091 obo:IAO_0000115 "An abnormally increased level of tyrosine in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased tyrosine in urine" ; a owl:Class ; rdfs:label "Tyrosinuria" ; rdfs:subClassOf obo:HP_0033090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033092 obo:IAO_0000115 "The concentration of succinate in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; a owl:Class ; rdfs:comment "Succinate is a Krebs cycle metabolite that is able to modulate inflammatory responses." ; rdfs:label "Increased urine succinate level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0033093 obo:IAO_0000115 "An elevated level of an glutamine family amino acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased glutamine family amino acid level in urine" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033094 obo:IAO_0000115 "An increased concentration of glutamate in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased glutamic acid in urine" ; a owl:Class ; rdfs:label "Increased urine glutamate level" ; rdfs:subClassOf obo:HP_0033093 . obo:HP_0033095 obo:IAO_0000115 "An elevated level of a sulfur-containing amino acid in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased sulfur-containing amino acid level in urine", "Increased sulphur amino acid level in urine" ; a owl:Class ; rdfs:label "Increased sulfur amino acid level in urine" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033096 obo:IAO_0000115 "An elevated level of an aspartate family amino acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased aspartate family amino acid level in urine" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033097 obo:IAO_0000115 "An elevated urine level of a compound that is derived from an amino acid." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urine proteinogenic amino acid derivative level" ; rdfs:subClassOf obo:HP_0003355 . obo:HP_0033098 obo:IAO_0000115 "An increased level in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urinary non-proteinogenic amino acid level" ; a owl:Class ; rdfs:label "Increased urinary non-proteinogenic amino acid level" ; rdfs:subClassOf obo:HP_0003355 . obo:HP_0033099 obo:IAO_0000115 "An increased level of a serine family amino acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased serine family amino acid in urine" ; rdfs:subClassOf obo:HP_0033100 . obo:HP_0033100 obo:IAO_0000115 "An elevated level of a proteinogenic amino acid in the urine. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proteinogenic amino acid level in urine" ; rdfs:subClassOf obo:HP_0003355 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_83813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033101 obo:IAO_0000115 "An abnormally increased level of aconitic acid in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine aconitic acid level" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0033102 obo:IAO_0000115 "The femoral neck region shows medial metaphyseal beaking and a significant enlargement of the lesser trochanter (with some enlargement also of the greater trochanter), producing a monkey wrench (Swedish key) configuration of the proximal femur. A monkey wrench refers to a type of adjustable wrench with one fixed and one adjustable jaw at right angles to a straight handle." ; dcterms:creator ; oboInOwl:hasExactSynonym "Monkey wrench appearance of femoral neck", "Monkey wrench configuration of the proximal femur", "Swedish key appearance of femoral neck", "Swedish key configuration of the proximal femur" ; a owl:Class ; rdfs:label "Monkey wrench femoral neck" ; rdfs:subClassOf obo:HP_0003367 . obo:HP_0033103 obo:IAO_0000115 "Increased concentration of chitinase 3-like 1 (CHI3L1) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating YKL40 level", "Elevated circulating chitinase 3-like 1 level" ; a owl:Class ; rdfs:comment "Chitinase 3-like 1 (CHI3L1; previously known as YKL-40) is a glycoprotein with homology to the chitinase protein family, but without chitinase activity. Elevations of serum CHI3L1 can be measured by ELISA and are related to some kinds of bone disease." ; rdfs:label "Elevated circulating CHI3L1 level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033104 obo:IAO_0000115 "Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response." ; dc:date "2020-08-29T13:06:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The induction and maintenance of fever during infection involves the tightly coordinated interplay between the innate immune system and neuronal circuitry within the central and peripheral nervous systems. Some diseases (such as Hyper-IgE recurrent infection syndrome 5, autosomal recessive, which is due to IL6R mutation) are associated with a lack of clinically adequate inflammatory response in the face of marked infection." ; rdfs:label "Inappropriate absence of fever" ; rdfs:subClassOf obo:HP_0004370 . obo:HP_0033105 obo:IAO_0000115 "An abnormal parenchymal band connecting the medial margins of the left and right hypothalami across the third ventricle." ; dc:date "2020-08-29T11:25:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypothalamic adhesion" ; a owl:Class ; rdfs:comment "The appearance of the interhypothalamic adhesions visible in the sagittal plane as an additional small ovoid structure between the fornices and lamina terminalis, centered near the level of the midbrain cranial margin. Anatomically, this location corresponds to the anterior and tuberalis regions of the periventricular hypothalamus." ; rdfs:label "Interhypothalamic adhesion" ; rdfs:subClassOf obo:HP_0012286 . obo:HP_0033106 obo:IAO_0000115 "An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation." ; dc:date "2020-08-29T11:29:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated D-dimers", "Elevated fibrin degradation fragment concentration" ; a owl:Class ; rdfs:comment "The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. First, thrombin cleaves fibrinogen producing fibrin monomers, which polymerize and serve as a template for factor XIIIa and plasmin formation. Second, thrombin activates plasma factor XIII bound to fibrin polymers to produce the active transglutaminase, factor XIIIa. Factor XIIIa catalyzes the formation of covalent bonds between D-domains in the polymerized fibrin. Finally, plasmin degrades the crosslinked fibrin to release fibrin degradation products and expose the D-dimer antigen. D-dimer measurement has been most comprehensively validated in (1) the exclusion of venous thromboembolism (VTE) in certain patient populations and (2) the diagnosis and monitoring of coagulation activation in disseminated intravascular coagulation. Anormal D-dimer in the appropriate clinical context denotes that there is no major ongoing activation of intravascular coagulation, and serves as a reliable tool for the exclusion of VTE." ; rdfs:label "Elevated circulating D-dimer concentration" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0033107 obo:IAO_0000115 "An elevated level of a proteinogenic amino acid in the blood circulation. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine." ; dc:date "2020-08-29T11:59:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating proteinogenic amino acid concentration" ; rdfs:subClassOf obo:HP_0003112 . obo:HP_0033108 obo:IAO_0000115 "Any deviation from the normal concentration in the blood circulation of a compound that is derived from an amino acid." ; dc:date "2020-08-29T12:01:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating proteinogenic amino acid derivative concentration" ; rdfs:subClassOf obo:HP_0003112 . obo:HP_0033109 obo:IAO_0000115 "Any deviation from the normal concentration in the blood circulation of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." ; dc:date "2020-08-29T12:04:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating non-proteinogenic amino acid concentration" ; rdfs:subClassOf obo:HP_0003112 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_83820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033110 obo:IAO_0000115 "An abnormally increased level of alpa-aminobutyric acid in the blood circulation. Alpha-aminobutyric acid alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2." ; dc:date "2020-08-29T12:06:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating homoalanine concentration" ; a owl:Class ; rdfs:label "Elevated circulating alpha-aminobutyric acid concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0033111 obo:IAO_0000115 "Concentration of 3-hydroxyisovaleric acid in the urine above the normal range." ; dc:date "2020-08-29T12:10:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urine 3-hydroxyisovaleric acid level" ; a owl:Class ; rdfs:label "3-hydroxyisovaleric aciduria" ; rdfs:subClassOf obo:HP_0001992 . obo:HP_0033112 obo:IAO_0000115 "An increased concentration in blood of apolipoprotein C-III, a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons." ; dc:date "2020-08-30T11:30:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated APOC3 level", "Elevated apolipoprotein C-III level" ; a owl:Class ; rdfs:label "Elevated circulating apolipoprotein C-III concentration" ; rdfs:subClassOf obo:HP_0033460 . obo:HP_0033113 obo:IAO_0000115 "In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse." ; dc:date "2020-08-30T11:33:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Triple rhythm" ; a owl:Class ; rdfs:label "Gallop rhythm" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0033114 obo:IAO_0000115 "A type of gallop rhytm in which both the third and the fourth sounds are present." ; dc:date "2020-08-30T12:35:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Quadruple gallop rhythm" ; rdfs:subClassOf obo:HP_0033113 . obo:HP_0033115 obo:IAO_0000115 "Abnormally increased concentration of tenascin-C in the blood circulation." ; dc:date "2020-09-03T11:21:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Tenascin-C is a pro-inflammatory glycoprotein. The expression of tenascin-C in adults is limited to the site of tissue injury, usually temporary, and the expression level of tenascin-C returns to normal after tissue repair is completed. In contrast, the sustained high expression of tenascin-C is common in inflammation, tissue remodeling, and autoimmune diseases. Elevated serum tenascin-C may be associated with severity and poor prognosis in septic patients." ; rdfs:label "Elevated circulating tenascin-C level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033116 obo:IAO_0000115 "Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border." ; dc:date "2020-09-03T11:59:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Despite structural analogy, the epithelium in the duodenal gastric metaplasia (DGM) differs from true gastric epithelium with respect to lectin composition. DGM is considered to be an acquired condition related to gastric acid injury and H pylori may also be associated in its pathogenesis" ; rdfs:label "Duodenal gastric metaplasia" ; rdfs:subClassOf obo:HP_0002246 . obo:HP_0033117 obo:IAO_0000115 "Inflammation of the lining of the upper small intestine (duodenum)." ; dc:date "2020-09-03T12:01:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Duodenal inflammation" ; a owl:Class ; rdfs:comment "The diagnosis of duodenitis is made when there is infiltration by inflammatory cells with changes in villous architecture and surface and crypt epithelium. Duodenitis can be graded according to the amount of neutrophilic and plasma cell infiltration, villous height, Brunner's gland hyperplasia with prolapse into the lamina propria and gastric metaplasia." ; rdfs:label "Duodenitis" ; rdfs:subClassOf obo:HP_0002246 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033118 obo:IAO_0000115 "Anomalous physiology (function) of the right ventricle." ; dc:date "2020-09-03T12:06:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal right ventricular function" ; rdfs:subClassOf obo:HP_0030872 . obo:HP_0033119 obo:IAO_0000115 "Elevation of right ventricular systolic pressure (RVSP) above normal limits. In adults, RVSP is normally 20-30 mmHg." ; dc:date "2020-09-03T12:08:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In the absence of right ventricular (RV) outflow tract obstruction, RV systolic pressure is equal to pulmonary artery systolic pressure. The gold standard for the measurement of PH is right heart catheterization, but this is invasive with the inherent risk of complications. Echocardiography has been touted as providing an accurate measurement of the right ventricular systolic pressure based on the estimated flow of the tricuspid regurgitant jet." ; rdfs:label "Elevated right ventricular systolic pressure" ; rdfs:subClassOf obo:HP_0033118 . obo:HP_0033120 obo:IAO_0000115 "A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet" ; dc:date "2020-09-03T12:14:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Discoid eczema", "Nummular dermatitis" ; a owl:Class ; rdfs:label "Nummular eczema" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0033121 obo:IAO_0000115 "A cough with a characteristic sound that has been compared to a seal's bark." ; dc:date "2020-09-03T12:36:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Seal-like barking cough" ; a owl:Class ; rdfs:label "Barking cough" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0033122 obo:IAO_0000115 "The P wave that normally precedes each QRS complex by a fixed PR interval of 120 to 200 milliseconds is not present." ; dc:date "2020-09-05T12:45:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence of P wave on electrocardiography" ; a owl:Class ; rdfs:comment "Absent P wave can be observed with conditions including atrial fibrillation and sinoatrial arrest," ; rdfs:label "Absent P wave" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0033123 obo:IAO_0000115 "Abnormally increased level of osteopontin in the blood circulation" ; dc:date "2020-09-05T12:56:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Osteopontin (OPN, also known as Eta-1) is a noncollagenous matrix protein produced by macrophages and T lymphocytes. Plasma OPN levels can be elevated in a range of diseases including tuberculosis and systemic lupus erythematosus." ; rdfs:label "Elevated circulating osteopontin level" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033124 obo:IAO_0000115 "An increased level of sorbitol in the blood circulation." ; dc:date "2020-09-05T13:02:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased serum sorbitol concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0033125 obo:IAO_0000115 "An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement." ; dc:date "2020-09-05T13:05:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Follicular lymphoma" ; rdfs:subClassOf obo:HP_0012191 . obo:HP_0033126 obo:IAO_0000115 "Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red coloured skin." ; dc:date "2020-09-05T13:12:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin necrosis" ; a owl:Class ; rdfs:label "Cutaneous necrosis" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0033127 obo:IAO_0000115 "An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body." ; dc:date "2020-09-05T13:35:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormality of the musculoskeletal system" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0033128 obo:IAO_0000115 "A failure to achieve the ability to crawl at an appropriate developmental stage. Normal infant motor development is marked by a series of postural milestones including learning to crawl on hands and knees between the ages of 6 and 10 months." ; dc:date "2020-09-05T13:40:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed ability to crawl" ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0033129 obo:IAO_0000115 "Anopmalous function of the shoulder. The shoulder is a ball-and-socket joint that is made up of humerus, scapula and clavicle, which are connected by the sternoclavicular joint (SC), the acromioclavicular joint (AC), the glenohumeral joint (GH), and the scapulothoracic joint (ST). The GH, AC and SC joints link the upper extremity to the axial skeleton at the thorax and enable movement at the shoulder joint: flexion, extension, and rotation of the arm." ; dc:date "2020-09-05T13:42:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal shoulder physiology" ; rdfs:subClassOf obo:HP_0034430 . obo:HP_0033130 obo:IAO_0000115 "Anomalous echogenicity of the kidney on ultrasound examination." ; dc:date "2020-09-09T12:48:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "For diagnostic ultrasonography, high-frequency sound waves are generated and received by the ultrasonography transducer, which is placed on the skin. Returning sound waves (echoes) are processed by a computer and displayed on a computer screen. A gray-scale image is produced when the ultrasonography machine operates in B-mode, or brightness mode, in which returning echoes are represented as bright dots; the brightness of the dots represents the strength of the reflected echoes. Echogenicity, therefore, refers to how bright or dark something appears in the gray-scale image; the brighter something appears, the more echogenic it is. With regard to the kidney, echogenicity generally refers to how bright or dark the kidney parenchyma appears in comparison to the liver." ; rdfs:label "Abnormal renal echogenicity" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0033131 obo:IAO_0000115 "Increased echogenecity of the medullary region of the kidney." ; dc:date "2020-09-09T12:57:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased renal medullary echogenicity" ; a owl:Class ; rdfs:comment "Increased echogenicity of the kidney parenchyma results from the increased presence of material that can reflect sound waves back, thus increasing its brightness on the ultrasonography image. Because fibrous tissue (e.g., glomerulosclerosis, interstitial fibrosis) increases echogenicity, CKD is typically associated with increased echogenicity. Inflammatory infiltrates may explain the increased echogenicity that occurs with acute interstitial nephritis and GN. Proteinaceous casts are thought to cause the increased echogenicity associated with acute tubular necrosis (ATN). Calcium deposits and stones are very echogenic; thus, medullary nephrocalcinosis is characterized by increased medullary echogenicity and a relatively normal-appearing cortex. Several renal diseases are associated with medullary nephrocalcinosis, including medullary sponge kidney, hyperparathyroidism, renal tubular acidosis, and vitamin D toxicity. Other kidney diseases that have been associated with a hyperechoic medulla include sickle cell disease and gout" ; rdfs:label "Renal medullary hyperechogenicity" ; rdfs:subClassOf obo:HP_0033130 . obo:HP_0033132 obo:IAO_0000115 "Increased echogenecity of the kidney cortex." ; dc:date "2020-09-09T13:01:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal cortical hyperechogenicity" ; rdfs:subClassOf obo:HP_0033130 . obo:HP_0033133 dc:date "2020-09-09T13:03:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoechogenic renal cortex" ; a owl:Class ; rdfs:label "Renal cortical hypoechogeneity" ; rdfs:subClassOf obo:HP_0033130 . obo:HP_0033134 obo:IAO_0000115 "Fibrous bands (i.e., bands of scar-like tissue) that span two or more intra-abdominal organs and/or the inner abdominal wall (i.e. peritoneal membrane)." ; dc:date "2020-09-09T13:12:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intra-abdominal adhesion" ; a owl:Class ; rdfs:comment "Abdominal adhesions typically form after abdominal surgery but may also occur secondary to inflammatory conditions of the abdomen in the absence of prior abdominal surgery or as a sequela of abdomino-pelvic radiation. Although the majority of patients with intra-abdominal adhesions remain asymptomatic, a clinically significant subset of patients will develop adhesive disease, a symptomatic state ranging from mild and/or vague to highly distressing and even life-threatening symptoms." ; rdfs:label "Abdominal adhesions" ; rdfs:subClassOf obo:HP_0001438 . obo:HP_0033135 obo:IAO_0000115 "Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia. Liver infarctions appear as hypoechoic nonvascular regions on conventional and Doppler sonography." ; dc:date "2020-09-09T13:23:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hepatic infarction is infrequent due to the dual blood supply of the liver and the compensatory relationship between the hepatic artery and portal vein." ; rdfs:label "Hepatic infarction" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0033136 obo:IAO_0000115 "An inflammed lymph node that is filled with pus." ; dc:date "2020-09-09T13:33:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lymph node abscess" ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0033137 obo:IAO_0000115 "A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli." ; dc:date "2020-09-09T13:40:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary alveolar system morphology" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0033138 obo:IAO_0000115 "A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart." ; dc:date "2020-09-09T13:51:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Right atrial thrombus" ; rdfs:subClassOf obo:HP_0025580 . obo:HP_0033139 obo:IAO_0000115 "Concentration of uracil in the blood circulation is above the normal range." ; dc:date "2020-09-09T13:56:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating uracil concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0033140 obo:IAO_0000115 "The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna." ; dc:date "2020-09-12T15:35:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blake's pouch cyst" ; rdfs:subClassOf obo:HP_0000932 . obo:HP_0033141 obo:IAO_0000115 "Unusually severe clinical course of SARS-CoV-2 infection, manifested clinically by features such as dyspnea and hypoxia with diffuse bilateral ground-glass opacities of the lungs on computed tomographic scan with progressive respiratory insufficiency necessitating oxygen supplementation or mechanical ventilation." ; dc:date "2020-09-15T10:19:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe SARS-CoV-2 infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0033142 obo:IAO_0000115 "Increased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose." ; dc:date "2020-09-15T10:21:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Long nasal bridge" ; rdfs:subClassOf obo:HP_0000422 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033143 obo:IAO_0000115 "Inflammation of the lining of the middle section of the small intestine." ; dc:date "2020-09-15T10:25:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Jejunitis" ; rdfs:subClassOf obo:HP_0005265 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033144 obo:IAO_0000115 "Any deviation of the concentration of ceruloplasmin in the blood from the normal range." ; dc:date "2020-09-15T11:10:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Ceruloplasmin is a serum ferroxidase responsible for 90 percent of copper transport. Also, ceruloplasmin is a positive acute-phase reactant, meaning its levels will increase in inflammatory conditions or cell injury." ; rdfs:label "Abnormal circulating ceruloplasmin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033145 obo:IAO_0000115 "Elevated concentration of ceruloplasmin in the blood circulation." ; dc:date "2020-09-15T11:16:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating ceruloplasmin concentration" ; rdfs:subClassOf obo:HP_0033144 . obo:HP_0033146 obo:IAO_0000115 "Increased concentration of methylsuccinic acid in the blood circulation." ; dc:date "2020-09-19T11:29:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating methylsuccinic acid concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0033147 obo:IAO_0000115 "Any deviation from the normal concentration of a short-chain fatty acid in the blood circulation." ; dc:date "2020-09-19T11:37:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A short-chain fatty acid is defined as n aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." ; rdfs:label "Abnormal circulating short-chain fatty-acid concentration" ; rdfs:subClassOf obo:HP_0004359 . obo:HP_0033148 obo:IAO_0000115 "Increased concentration of isovaleric acid, a C5, branched-chain saturated fatty acid, in the blood concentration." ; dc:date "2020-09-19T11:42:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating isovalerate", "Isovalericacidemia" ; a owl:Class ; rdfs:label "Increased circulating isovaleric acid concentration" ; rdfs:subClassOf obo:HP_0033147 . obo:HP_0033149 obo:IAO_0000115 "Increased diameter (caliber) of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts)." ; dc:date "2020-09-19T12:51:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dilatation of intrahepatic biliary ducts" ; a owl:Class ; rdfs:label "Intrahepatic bile duct dilatation" ; rdfs:subClassOf obo:HP_0011040 . obo:HP_0033150 obo:IAO_0000115 "An abscess located at the junction of the anal canal and the rectum." ; dc:date "2020-09-20T11:07:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anorectal abscess" ; rdfs:subClassOf obo:HP_0002034, obo:HP_0025615 . obo:HP_0033151 obo:IAO_0000115 "A structural anomaly of the pharynx." ; dc:date "2020-09-20T11:17:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pharynx morphology" ; rdfs:subClassOf obo:HP_0000600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033152 obo:IAO_0000115 "A functional anomaly of the pharynx." ; dc:date "2020-09-20T11:18:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pharynx physiology" ; rdfs:subClassOf obo:HP_0000600 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033153 obo:IAO_0000115 "An abnormally increased circulation of dodecenoylcarnitine, C12:1, in the blood circulation." ; dc:date "2020-09-19T12:32:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated plasma dodecenoylcarnitine concentration" ; a owl:Class ; rdfs:label "Elevated circulating dodecenoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0033154 obo:IAO_0000115 "An increased concentration of lysyl-pyridinoline (deoxypyridinoline) cross-links in the blood circulation." ; dc:date "2020-09-20T11:19:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pyridinoline cross-links contribute to the structural rigidity and integrity of collagen fibrils in bone. When bone resorption occurs, osteoclastic degradation of bone matrix releases pyridinoline and deoxypyridinoline into the circulation; these compounds are then excreted in urine. Measurements of urinary elimination of these compounds may provide useful information on the change of bone resorption." ; rdfs:label "Elevated circulating deoxypyridinoline concentration" ; rdfs:subClassOf obo:HP_0033386 . obo:HP_0033155 obo:IAO_0000115 "Abnormally increased concentration of L-alloisoleucine in the blood circulation." ; dc:date "2020-09-20T11:33:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Elevated alloisoleucine in serum or urine is characteristic of Maple syrup urine disease." ; rdfs:label "Elevated circulating L-alloisoleucine concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0033156 obo:IAO_0000115 "Abnormally increased level of L-alloisoleucine in the urine." ; dc:date "2020-09-20T12:04:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Elevated alloisoleucine in serum or urine is characteristic of Maple syrup urine disease." ; rdfs:label "Elevated urine L-alloisoleucine level" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0033157 obo:IAO_0000115 "Abnormal increase of the concentration of 3-methylhistidine in the blood circulation." ; dc:date "2020-09-20T12:20:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The rate of myofibrillar protein breakdown may be estimated from the urinary excretion of 3-methylhistidine. This amino acid is formed by the methylation of peptide-bound histidine in actin and myosin, is excreted in the urine when these proteins are broken down, and is not reused for protein synthesis." ; rdfs:label "Elevated circulating 3-methylhistidine concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0033158 obo:IAO_0000115 "An abnormal reduction in the number of beats per unit time of the respiratory cilia." ; dc:date "2020-09-20T13:24:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dminished respiratory ciliary beat frequency" ; a owl:Class ; rdfs:comment "Respiratory cilia beat in a coordinated manner with a specific frequency and pattern, clearing mucus and debris from the airways. In primary ciliary dyskinesia cilia are either stationary or beat in a slow or dyskinetic fashion. Impaired mucociliary clearance in these patients is associated with recurrent chest infections, which may lead to bronchiectasis and sinusitis. The diagnosis of primary ciliary dyskinesia is made on the basis of a supportive clinical history and an abnormal ciliary beat frequency accompanied in most cases by specific abnormalities of the ciliary axoneme on electron microscopy." ; rdfs:label "Reduced respiratory ciliary beating frequency" ; rdfs:subClassOf obo:HP_0012261 . obo:HP_0033159 obo:IAO_0000115 "Decreased level of inosine in urine. Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond." ; dc:date "2020-09-24T09:10:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced urinary inosine level" ; rdfs:subClassOf obo:HP_0033161 . obo:HP_0033160 obo:IAO_0000115 "Decreased level of guanosine in urine. Guanosine is a purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond." ; dc:date "2020-09-24T09:11:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary guanosine level" ; rdfs:subClassOf obo:HP_0033161 . obo:HP_0033161 obo:IAO_0000115 "Any deviation from the normal amount of a purine compound in the urine. Purines are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. Two of the four deoxyribonucleotides (deoxyadenosine and deoxyguanosine) and two of the four ribonucleotides (adenosine, or AMP, and guanosine, or GMP) are purines." ; dc:date "2020-09-24T09:13:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary purine level" ; rdfs:subClassOf obo:HP_0032572 . obo:HP_0033162 obo:IAO_0000115 "Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines." ; dc:date "2020-09-24T09:15:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary pyrimidine level" ; rdfs:subClassOf obo:HP_0032572 . obo:HP_0033163 obo:IAO_0000115 "An increased number and/or abnormal type of bacteria in the small bowel. Small intestinal bacterial overgrowth has been defined as the presence of greater than one hundred thousand bacteria (i.e. colony-forming units, CFU) per mL of proximal jejunal aspiration. The normal value is ten thousand or few CFU/ml." ; dc:date "2020-09-24T09:20:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small intestinal bacterial overgrowth" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0033164 obo:IAO_0000115 "Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation." ; dc:date "2020-09-24T09:27:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Focal crypt injury by neutrophils (cryptitis/crypt abscesses), or focal active colitis (FAC), is a common isolated finding in endoscopic colorectal biopsies. Focal active colitis is often thought of as a feature of Crohn's disease, but may also be seen in ischemia, infections, partially treated ulcerative colitis, and as an isolated finding in patients undergoing endoscopy to exclude neoplasia." ; rdfs:label "Focal active colitis" ; rdfs:subClassOf obo:HP_0002583 . obo:HP_0033165 obo:IAO_0000115 "Inflammation of the intestine leading to bacterial invasion causing cellular damage and death which causes necrosis of the colon and intestine." ; dc:date "2020-09-24T09:32:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Necrotizing enterocolitis almost exclusively affects neonates." ; rdfs:label "Necrotizing enterocolitis" ; rdfs:subClassOf obo:HP_0004387 . obo:HP_0033166 obo:IAO_0000115 "An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis)." ; dc:date "2020-09-24T09:36:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent viral upper respiratory tract infections" ; rdfs:subClassOf obo:HP_0002788, obo:HP_0004429 . obo:HP_0033167 obo:IAO_0000115 "A neutrophilic interstitial, perivascular and/or perieccrine infiltrate with leukocytoclasia. Notably, leukocytoclastic vasculitis is not present." ; dc:date "2020-09-24T09:39:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Neutrophilic urticarial dermatosis is typically accompanied by systemic symptoms including fever and arthralgias." ; rdfs:label "Neutrophilic urticarial dermatosis" ; rdfs:subClassOf obo:HP_0001025 . obo:HP_0033168 obo:IAO_0000115 "Abnormally reduced activity of mevalonate kinase, which is a key enzyme in the mevalonate biosynthetic pathway that leads to the synthesis of both cholesterol and nonsterol isoprenoids." ; dc:date "2020-09-24T09:42:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced mevalonate kinase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0033169 obo:IAO_0000115 "Abnormally reduced volume of air in the lungs upon the maximum effort of inspiration." ; dc:date "2020-09-24T10:13:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced TLC" ; a owl:Class ; rdfs:label "Reduced total lung capacity" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033170 obo:IAO_0000115 "Any deviation from the normal range of a skinfold thickness, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers." ; dc:date "2020-09-24T10:24:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal skinfold thickness measurement" ; rdfs:subClassOf obo:HP_0004323 . obo:HP_0033171 obo:IAO_0000115 "Any deviation from the normal range of the thickness of the tricpes skinfold, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers." ; dc:date "2020-09-24T10:27:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal triceps skinfold thickness" ; rdfs:subClassOf obo:HP_0033170 . obo:HP_0033172 obo:IAO_0000115 "Increased thickness of the triceps skinfold, which is measured halfway down the back of the upper arm is increased." ; dc:date "2020-09-24T10:29:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased triceps skinfold thickness" ; rdfs:subClassOf obo:HP_0033171 . obo:HP_0033173 obo:IAO_0000115 "Return of lavage fluid with a milky apperance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space." ; dc:date "2020-09-24T10:42:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is characteristically observed in pulmonary alveolar proteinosis." ; rdfs:label "Milky appearance of bronchoalveolar lavage fluid" ; rdfs:subClassOf obo:HP_0032973 . obo:HP_0033174 obo:IAO_0000115 "Return of lavage fluid characteristically has a bloody apperance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding." ; dc:date "2020-09-24T10:47:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bloody bronchoalveolar lavage fluid" ; rdfs:subClassOf obo:HP_0032973 . obo:HP_0033175 obo:IAO_0000115 "Concentration of L-pyroglutamic acid in the blood is above the upper limit of normal." ; dc:date "2020-09-24T10:49:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating L-pyroglutamic acid concentration" ; a owl:Class ; rdfs:comment "5-oxoproline is an oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle." ; rdfs:label "Elevated circulating 5-oxoproline concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0033176 obo:IAO_0000115 "Increased size of the lymph nodes that are located beneath the mandible (lower jaw)." ; dc:date "2020-09-25T12:46:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Submandibular lymphadenopathy" ; a owl:Class ; rdfs:label "Submandibular lymph node enlargement" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0033177 obo:IAO_0000115 "An increased concentration of suberic acid in the blood circulation. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane." ; dc:date "2020-09-25T12:49:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating suberic acid concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0033178 obo:IAO_0000115 "An increased concentration of interleukin-8 in the circulation." ; dc:date "2020-09-28T22:05:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased serum IL-8", "Increased serum interleukin 8", "Increased serum interleukin-8" ; a owl:Class ; rdfs:comment "IL-8 is a chemokine that acts as a chemotactic factor secreted by activated monocytes and macrophages that promotes the directional migration of neutrophils, basophils, and T lymphocytes." ; rdfs:label "Increased circulating interleukin 8 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0033179 obo:IAO_0000115 "Concentration of aconitic acid in the blood circulation above the upper limit of normal." ; dc:date "2020-09-28T22:12:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating aconitic acid concentration" ; rdfs:subClassOf obo:HP_0004354 . obo:HP_0033180 obo:IAO_0000115 "The appendix testis or hydatid of Morgagni, is a vestigial remnant of the Müllerian duct located on the superior pole of the testicle between the testis and epididymis. Although this appendage has no vital function, it is present in 50% of males. Torsion of twisting of this vestigial remnant can be incredibly painful, but usually requires no medical intervention." ; dc:date "2020-09-28T22:15:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Twisted vestigial remnant of the Muellerian duct" ; a owl:Class ; rdfs:label "Torsion of appendix of testis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0033181 obo:IAO_0000115 "Spinal epidural abscess (SEA) is caused by a suppurative infection in the epidural space. The mass effect of the abscess can compress and reduce blood flow to the spinal cord, conus medullaris, or cauda equina." ; dc:date "2020-09-28T22:20:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "A severe pyogenic infection of the epidural space" ; a owl:Class ; rdfs:comment "Left untreated, the infection can lead to sensory loss, muscle weakness, visceral dysfunction, sepsis, and even death. Early diagnosis is essential to limit morbidity and neurologic injury. The classic triad of fever, axial pain, and neurological deficit occurs in as few as 13 percent of patients, highlighting the diagnostic challenge associated with SEA." ; rdfs:label "Spinal epidural abscess" ; rdfs:subClassOf obo:HP_0025615 . obo:HP_0033182 obo:IAO_0000115 "An increase in concentration of cathepsin D in the blood circulation." ; dc:date "2020-09-28T22:29:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating cathepsin D level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0033183 obo:IAO_0000115 "A developmental defect of pulmonary lobation characterized by the presence of only two lobes of the right lung." ; dc:date "2020-10-04T11:44:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The normal anatomy of the right lung comprises three lobes: the upper, middle, and lower lobes, and that of the left lung consists of two lobes: the upper and lower lobes." ; rdfs:label "Bilobed right lung" ; rdfs:subClassOf obo:HP_0002101 . obo:HP_0033184 dc:date "2020-10-04T11:47:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Applies to a sign or symptom that is provoked or brought about by an infection, that is by invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body." ; rdfs:label "Triggered by infection" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0033185 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by infection by the Epstein-Barr virus." ; dc:date "2020-10-04T11:48:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Triggered by Epstein Barr virus infection" ; a owl:Class ; rdfs:label "Triggered by EBV infection" ; rdfs:subClassOf obo:HP_0033198 . obo:HP_0033186 obo:IAO_0000115 "The term is commonly used to describe a putative abnormal location of pulmonary vein branches adjacent to pulmonary arteries within the same adventitial sheath. However, evidence has been provided that the vessels in question are not pulmonary veins, however represent dilated bronchial veins." ; dc:date "2020-10-04T11:50:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Misalignment of the pulmonary veins" ; rdfs:subClassOf obo:HP_0030968 . obo:HP_0033187 obo:IAO_0000115 "Elevated levels of proline-containing dipeptides in urine." ; dc:date "2020-10-04T11:55:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Imidodipeptiduria" ; a owl:Class ; rdfs:comment "Prolidase splits dipeptides containing C-terminal proline or hydroxyproline. In prolidase deficiency, normal recycling of proline cannot occur, and this leads to iminopeptiduria, the characteristic biochemical abnormality. Glycylproline is the major urinary imidodipeptide. Leucylproline can also be identified in persons with prolidase deficiency." ; rdfs:label "Hyperimidodipeptiduria" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0033188 obo:IAO_0000115 "A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum." ; dc:date "2020-10-04T12:02:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cystic acne" ; rdfs:subClassOf obo:HP_0001061 . obo:HP_0033189 obo:IAO_0000115 "Tooth root length more than 2 SD above mean, or subjectively apparently increased tooth root length." ; dc:date "2020-10-04T12:04:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Long dental root", "Rhizomegaly", "Root gigantism" ; a owl:Class ; rdfs:label "Radiculomegaly" ; rdfs:subClassOf obo:HP_0040220 . obo:HP_0033190 obo:IAO_0000115 "A large nonpalpable spot of the skin over 1 cm in dimension with increased pigmentation and increased hair growth." ; dc:date "2020-10-04T12:07:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cutaneous hyperpigmentation with overlying hypertrichosis" ; a owl:Class ; rdfs:label "Hypertrichotic hyperpigmented patch" ; rdfs:subClassOf obo:HP_0000953 . obo:HP_0033191 obo:IAO_0000115 "An increased concentration of selenium in the blood circulation." ; dc:date "2020-10-04T12:16:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating selenium concentration" ; rdfs:subClassOf obo:HP_0031903 . obo:HP_0033192 obo:IAO_0000115 "An abnormally reduced concentration of selenium in the blood circulation." ; dc:date "2020-10-04T12:17:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating selenium concentration" ; rdfs:subClassOf obo:HP_0031903 . obo:HP_0033193 obo:IAO_0000115 "Swelling of the hepatocyte, rounding of its contour, and alteration of the cytoplasm, which takes on a reticulated, rarified, or flocculant quality. The cytoplasm of the ballooned hepatocytes often contains clumps of eosinophilic ropey material known as Mallory-Denk bodies (MDBs) or Mallory hyaline, which is composed of hyperphosphorylated misfolded intermediate filaments, ubiquitin, and ubiquitin-binding protein P62." ; dc:date "2020-10-10T15:47:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ballooning degeneration of hepatocytes" ; a owl:Class ; rdfs:comment "Mallory-Denk bodies are inclusions found within the cytoplasm of ballooned hepatocytes that are composed of cytokeratin filaments, they have a twisted-rope appearance." ; rdfs:label "Ballooning hepatocyte degeneration" ; rdfs:subClassOf obo:HP_0034713 . obo:HP_0033194 obo:IAO_0000115 "Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the mouth." ; dc:date "2020-10-10T15:50:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perioral erythema" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0033195 obo:IAO_0000115 "Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the anus." ; dc:date "2020-10-10T15:51:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perianal erythema" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0033196 obo:IAO_0000115 "Infiltration of portal fields by inflammatory cells." ; dc:date "2020-10-11T12:07:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hepatic portal inflammation" ; a owl:Class ; rdfs:comment "In nonalcoholic fatty liver disease, portal inflammation is comprised of cells referred to as chronic, i.e. lymphocytes, plasma cells, occasional eosinophils, monocytes." ; rdfs:label "Portal inflammation" ; rdfs:subClassOf obo:HP_0004297 . obo:HP_0033197 obo:IAO_0000115 "Infiltration of inflammatory cells in lobules of the liver. A focus of lobular inflammation can be defined as two or more inflammatory cells (neutrophils, lymphocytes and other mononuclear cells, eosinophils and microgranulomas) within the lobule present within the sinusoids or surrounding injured hepatocytes (ballooned or apoptotic hepatocytes)." ; dc:date "2020-10-11T12:10:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Each liver lobule is hexagonal in cross section and is centered on the central vein (teh central veins are branches of the hepatic vein). Within lobules, hepatocytes are arranged into hepatic cords separated by adjacent sinusoids." ; rdfs:label "Hepatic lobular inflammation" ; rdfs:subClassOf obo:HP_0030146 . obo:HP_0033198 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by infection by a virus." ; dc:date "2020-10-11T12:16:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by viral infection" ; rdfs:subClassOf obo:HP_0033184 . obo:HP_0033199 obo:IAO_0000115 "An elevation of the concentration of interleukin 10 in the blood circulation." ; dc:date "2020-10-11T12:18:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased serum interleukin 10" ; a owl:Class ; rdfs:comment "IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology." ; rdfs:label "Increased circulating interleukin 10 concentration" ; rdfs:subClassOf obo:HP_0034162 . obo:HP_0033200 obo:IAO_0000115 "Reduced intensity of the triceps tendon reflex." ; dc:date "2020-10-11T14:23:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyporeflexia of triceps" ; a owl:Class ; rdfs:label "Triceps hyporeflexia" ; rdfs:subClassOf obo:HP_0012391 . obo:HP_0033201 obo:IAO_0000115 "Reduced intensity of the biceps tendon reflex." ; dc:date "2020-10-11T14:24:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyporeflexia of biceps" ; a owl:Class ; rdfs:label "Biceps hyporeflexia" ; rdfs:subClassOf obo:HP_0012391 . obo:HP_0033202 obo:IAO_0000115 "Reduced intensity of the brachioradialis tendon reflex." ; dc:date "2020-10-11T14:26:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The brachioradialis reflex is a deep tendon reflex involving the C5 and C6 nerve roots through its innervation by the radial nerve. To test brachioradialis reflex, the forearm is supported in a slightly pronated position. Then, the physician delivers a series of quick hits with the reflex hammer to the area of the styloid process of the radius at the point of brachioradialis insertion." ; rdfs:label "Brachioradialis hyporeflexia" ; rdfs:subClassOf obo:HP_0012391 . obo:HP_0033203 obo:IAO_0000115 "Increased intensity of the brachioradialis reflex." ; dc:date "2020-10-11T14:29:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The brachioradialis reflex is a deep tendon reflex involving the C5 and C6 nerve roots through its innervation by the radial nerve. To test brachioradialis reflex, the forearm is supported in a slightly pronated position. Then, the physician delivers a series of quick hits with the reflex hammer to the area of the styloid process of the radius at the point of brachioradialis insertion." ; rdfs:label "Brachioradialis hyperreflexia" ; rdfs:subClassOf obo:HP_0007054, obo:HP_0007350 . obo:HP_0033204 obo:IAO_0000115 "Increased intensity of the triceps reflex." ; dc:date "2020-10-11T14:37:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triceps hyperreflexia" ; rdfs:subClassOf obo:HP_0007350 . obo:HP_0033205 obo:IAO_0000115 "Increased intensity of the biceps reflex." ; dc:date "2020-10-11T14:38:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "To test the biceps reflex, the examinar should support the forearm of the patient, e.g., by placing it on the forearm of the examiner. The arm is midway between flexion and extension. The examiner places a thumb firmly over the biceps tendon, with the fingers curling around the elbow, and taps briskly. With a normal response, the forearm will flex at the elbow." ; rdfs:label "Biceps hyperreflexia" ; rdfs:subClassOf obo:HP_0007350 . obo:HP_0033206 obo:IAO_0000115 "Increased intensity of the Achilles reflex." ; dc:date "2020-10-11T14:41:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperactive ankle jerk reflex", "Hyperactive ankle reflex" ; a owl:Class ; rdfs:label "Hyperactive Achilles reflex" ; rdfs:subClassOf obo:HP_0002395 . obo:HP_0033207 obo:IAO_0000115 "Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures." ; dc:date "2020-10-12T11:13:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Complement receptor type 2 (CR2, CD21) is a 145-kD glycosylated single polypeptide chain consisting of a long extracellular domain of 15 to 16 short consensus repeat sequences, a transmembrane region, and a short cytoplasmic domain. The receptor is expressed on B cells, follicular dendritic cells, thymocytes and a subset of peripheral T cells. CD21 binds complement fragments C3d, C3dg and iC3b that are covalently bound to target antigens. On B cells, CD21 forms a complex together with CD19 and CD81, which functions as a coreceptor to the BCR. Upon simultaneous binding of complement-tagged antigens by CD21 and the BCR the threshold for B cell activation is reduced. Under these circumstances, CD21 acts as a bridge between the coreceptor complex and the BCR. Because CD21 augments B-cell receptor (BCR)-mediated signaling as part of the B-cell coreceptor complex, its downregulation may confer a state of anergy to these cells, as has been demonstrated among CD21-/low B cells in patients with rheumatoid arthritis, common variable immunodeficiency or hepatitis C associated cryoglobulinemia patients. These CD21-/low B cells are enriched in autoreactive clones that are unresponsive to BCR stimulation." ; rdfs:label "Increased proportion autoreactive unresponsive CD21-/low B cells" ; rdfs:subClassOf obo:HP_0025539 . obo:HP_0033208 obo:IAO_0000115 "A developmental defect of the alveolar airspace during cananicular lung development characterized by a decreased number of pulmonary capillaries located away from the alveolar epithelium, thickened alveolar septae, media hypertrophy of small pulmonary arteries and muscularization of distal arterioles, and in some cases lymphangiectasis." ; dc:date "2020-10-12T11:18:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alveolar capillary dysplasia" ; rdfs:subClassOf obo:HP_4000060 . obo:HP_0033209 obo:IAO_0000115 "Arrest of lung development in the pseudoglandular stage (weeks 8 to 16 of human gestation) resulting in small sized lungs, predominantly composed of bronchial and bronchiolar structures embedded in abundant loose mesenchyme that is poorly vascularized. Acinar structures are essentially absent, with no significant formation of saccules and no alveoli." ; dc:date "2020-10-12T11:21:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acinar dysplasia" ; rdfs:subClassOf obo:HP_0006703 . obo:HP_0033210 obo:IAO_0000115 "Arrest of lung development in the cananicular stage (weeks 18 to 26 of human gestation) resulting in simplified acinar spaces, frequently with abundant intervening mesenchyme and no alveoli. In later arrest growth stages early saccular formations may be seen. May resemble the lobular maldevelopment often seen in alveolar capillary dysplasia/misaligment of the pulmonary veins without vein misalignment or marked hypertensive changes of the pulmonary arteries." ; dc:date "2020-10-12T11:35:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Congenital alveolar dysplasia" ; rdfs:subClassOf obo:HP_0006703 . obo:HP_0033211 obo:IAO_0000115 "A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity." ; dc:date "2020-10-12T12:01:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased total iron binding capacity" ; rdfs:subClassOf obo:HP_0033212 . obo:HP_0033212 obo:IAO_0000115 "Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added." ; dc:date "2020-10-12T12:02:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal total iron binding capacity" ; rdfs:subClassOf obo:HP_0011031 . obo:HP_0033213 obo:IAO_0000115 "The concentration of suberic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2020-10-12T12:09:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urine octanedioic acid level" ; a owl:Class ; rdfs:comment "Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane." ; rdfs:label "Elevated urine suberic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0033214 obo:IAO_0000115 "Increased susceptibility to viral pneumonia, as manifested by recurrent episodes of viral pneumonias." ; dc:date "2020-10-12T12:53:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent viral pneumonia" ; rdfs:subClassOf obo:HP_0004429, obo:HP_0006532 . obo:HP_0033215 dc:date "2020-10-24T11:27:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Blockage (obliteration) of the capillary lumen by increased extracellular collagenous matrix, with or without hyalinosis or foam cells." ; rdfs:label "Obliterative abnormality of the renal glomerulus" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0033216 obo:IAO_0000115 "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus. Distribution can include vascular pole, perihilar, tip or neither tip, perihilar or vascular." ; dc:date "2020-10-24T11:31:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyalin is a smooth, glassy-appearing, amorphous material resulting from the accumulation of serum proteins." ; rdfs:label "Glomerular hyalinosis" ; rdfs:subClassOf obo:HP_0033215 . obo:HP_0033217 obo:IAO_0000115 "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the vascular pole/perihilum." ; dc:date "2020-10-24T12:08:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyalin is a smooth, glassy-appearing, amorphous material resulting from the accumulation of serum proteins." ; rdfs:label "Perihilar glomerular hyalinosis" ; rdfs:subClassOf obo:HP_0033216 . obo:HP_0033218 obo:IAO_0000115 "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the tip/tubular pole." ; dc:date "2020-10-24T12:19:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyalin is a smooth, glassy-appearing, amorphous material resulting from the accumulation of serum proteins." ; rdfs:label "Glomerular hyalinosis at the tubular pole" ; rdfs:subClassOf obo:HP_0033216 . obo:HP_0033219 obo:IAO_0000115 "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at neither tip nor perihilar/vascular poles. Both the vascular and the tubular pole are present in the glomerular cross section." ; dc:date "2020-10-24T12:22:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyalin is a smooth, glassy-appearing, amorphous material resulting from the accumulation of serum proteins." ; rdfs:label "Glomerular hyalinosis away from the vascular and tubular poles" ; rdfs:subClassOf obo:HP_0033216 . obo:HP_0033220 obo:IAO_0000115 "An increased concentration of 2-ethylhydracylic acid in the urine." ; dc:date "2020-10-24T12:39:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urinary 2-ethylhydracylic acid", "Elevated urinary 2-methylbutyrylglycine" ; a owl:Class ; rdfs:comment "Isolated excretion of 2-ethylhydracrylic acid is the hallmark of short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD), a defect in the proximal pathway of L-isoleucine oxidation." ; rdfs:label "2-ethylhydracylic aciduria" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0033221 obo:IAO_0000115 "An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells." ; dc:date "2020-10-29T11:06:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased CD4:CD8 ratio" ; rdfs:subClassOf obo:HP_0031394 . obo:HP_0033222 obo:IAO_0000115 "An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells." ; dc:date "2020-10-29T11:10:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inverted CD4/CD8 ratio", "Inverted CD4:CD8 ratio" ; a owl:Class ; rdfs:comment "A low or inverted CD4/CD8 ratio is an immune risk phenotype and is associated with altered immune function, immune senescence, and chronic inflammation in both HIV-infected and uninfected populations." ; rdfs:label "Decreased CD4:CD8 ratio" ; rdfs:subClassOf obo:HP_0031394 . obo:HP_0033223 obo:IAO_0000115 "Any structural abnormality of the parietal epithelial cells that line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells at the urinary pole and with the podocytes at the vascular pole." ; dc:date "2020-10-30T10:23:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular parietal epithelial cell morphology" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0033224 obo:IAO_0000115 "Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering." ; dc:date "2020-10-30T10:27:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperplasia of the glomerular parietal epithelial cell" ; a owl:Class ; rdfs:label "Glomerular parietal epithelial cell hyperplasia" ; rdfs:subClassOf obo:HP_0033223 . obo:HP_0033225 obo:IAO_0000115 "An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present" ; dc:date "2020-10-30T10:42:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypertrophy of the glomerular parietal epithelial cell" ; a owl:Class ; rdfs:label "Glomerular parietal epithelial cell hypertrophy" ; rdfs:subClassOf obo:HP_0033223 . obo:HP_0033226 obo:IAO_0000115 "An insudative accumulation of amorphous, eosinophilic, periodic acid-Schiff (PAS)-positive, silver-negative material protruding from Bowman's capsule into the urinary space. Although not always evident by light microscopy, this material is located between Bowman's capsule and the parietal epithelial cells, in some cases associated with newly formed matrix material." ; dc:date "2020-10-30T11:00:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Capsular hyaline drops within Bowman's capsule" ; a owl:Class ; rdfs:label "Bowman capsular hyaline drops" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0033227 obo:IAO_0000115 "An area of basement membrane continuity between the glomerular tuft and Bowman's capsule, without intervening crescent and not adjacent to an area of segmental sclerosis." ; dc:date "2020-10-30T11:05:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular synechial adhesion" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033228 obo:IAO_0000115 "Inability to elicit triceps tendon reflex." ; dc:date "2020-10-30T11:15:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Areflexia of triceps" ; a owl:Class ; rdfs:label "Triceps areflexia" ; rdfs:subClassOf obo:HP_0012046 . obo:HP_0033229 obo:IAO_0000115 "Inability to elicit brachioradialis tendon reflex." ; dc:date "2020-10-30T11:16:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Areflexia of brachioradialis" ; a owl:Class ; rdfs:label "Brachioradialis areflexia" ; rdfs:subClassOf obo:HP_0012046 . obo:HP_0033230 obo:IAO_0000115 "Inability to elicit biceps tendon reflex." ; dc:date "2020-10-30T11:18:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Areflexia of biceps" ; a owl:Class ; rdfs:label "Biceps areflexia" ; rdfs:subClassOf obo:HP_0012046 . obo:HP_0033231 obo:IAO_0000115 "Abnormal number of its constituent cells of the mesangium of the glomerulus of the kidney." ; dc:date "2020-10-31T12:41:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular mesangial cellularity" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033232 obo:IAO_0000115 "Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix." ; dc:date "2020-10-31T12:50:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular mesangial matrix morphology" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033233 obo:IAO_0000115 "Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane." ; dc:date "2020-10-31T12:54:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "May be obsereved with IgA nephropathy." ; rdfs:label "Paramesangial deposits" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033234 obo:IAO_0000115 "Extracellular mesangial accumulation of moderately electron-dense, generally homogenous, amorphous-appearing extracellular material." ; dc:date "2020-10-31T12:56:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial hyaline deposition" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033235 obo:IAO_0000115 "Reduced ability to desscend stairs." ; dc:date "2020-10-31T13:07:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Difficulty walking down stairs" ; a owl:Class ; rdfs:label "Difficulty descending stairs" ; rdfs:subClassOf obo:HP_0004302 . obo:HP_0033236 obo:IAO_0000115 "A failure to sustain attention that requires self-motivation to optimize performance." ; dc:date "2020-10-31T13:20:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Central fatigue" ; a owl:Class ; rdfs:comment "Cognitive fatigue may be observed as decreased performance following prolonged effort over an extended period of time; decreased performance after a challenging mental exertion; decreased performance after a challenging physical exertion; and decreased performance during acute but sustained mental effort." ; rdfs:label "Cognitive fatigue" ; rdfs:subClassOf obo:HP_0012378 . obo:HP_0033237 obo:IAO_0000115 "Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'." ; dc:date "2020-11-01T12:37:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Detachment of visceral epithelial cells", "Podocyte detachment" ; a owl:Class ; rdfs:comment "Separation from GBM without intervening immune deposits. See Figure 5d of PMID:32866505." ; rdfs:label "Visceral epithelial cell detachment" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033238 obo:IAO_0000115 "Cytoplasmic projections into the urinary space from the luminal side of the podocyte." ; dc:date "2020-11-01T12:39:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Podocyte microvillous transformation" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033239 obo:IAO_0000115 "Layer of hypertrophied visceral epithelial cells overlying a sclerosed segment of the tuft of the glomerulus." ; dc:date "2020-11-01T12:45:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Podocyte cap" ; a owl:Class ; rdfs:label "Visceral epithelial cell capping" ; rdfs:subClassOf obo:HP_0020133 . obo:HP_0033240 obo:IAO_0000115 "An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation." ; dc:date "2020-11-24T10:58:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Hyperinflation on pulmonary function test", "Overinflation on pulmonary function test" ; a owl:Class ; rdfs:label "Elevated RV/TLC ratio" ; rdfs:subClassOf obo:HP_0033772 . obo:HP_0033241 obo:IAO_0000115 "An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold." ; dc:date "2020-11-24T11:11:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Indiviudals with polyalveolar lobe have some pulmonary function abnormalities, specifically a decrease in airway conductance, and forced expiratory volume." ; rdfs:label "Polyalveolar lobe" ; rdfs:subClassOf obo:HP_4000060 . obo:HP_0033242 obo:IAO_0000115 "A horseshoe lung is an uncommon congenital abnormality caused by the partial fusion of the bases of both lungs behind the pericardial sac." ; dc:date "2020-11-24T11:39:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Horseshoe lung" ; rdfs:subClassOf obo:HP_0002101 . obo:HP_0033243 obo:IAO_0000115 "Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components." ; dc:date "2020-11-24T11:51:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cell blebbing (bulky morphology of the cell, disruptin of cell membranes and organelles) and nucleus changes (shrunken nucleus fragments and chromatin condesation) is visible with electron microscope and DAPI staining. The release of cell contents initiates an inflammatory response in the surrounding tissue is detectable with hematoxylin and eosin staining." ; rdfs:label "Pulmonary necrosis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033244 obo:IAO_0000115 "Accumulation of immature interstitial cells containing abundant cytoplasmic glycogen defined by periodic acid-Schiff (PAS) positive cells." ; dc:date "2020-11-25T11:33:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glycogen accumulation in pulmonary interstitial cells" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033245 obo:IAO_0000115 "Any structural abnormality of alveolar type 2 (ATII) cells." ; dc:date "2020-11-25T11:37:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal alveolar epithelial type II cell morphology", "Abnormal pulmonary type II cell morphology", "Abnormal type II pneumocyte morphology" ; a owl:Class ; rdfs:comment "Alveolar type 1 (ATI) and type 2 (ATII) cells are specialized epithelial cells of the distal lung. ATI cells are flattened squamous cells that cover around 95% of the alveolar surface and lie adjacent to capillary endothelial cells to form the pulmonary gas exchange region. ATII cells have a compact morphology and cover the remaining 5% of the alveolar surface. The ultrastructural hallmark of ATII cells is the expression of lamellar bodies containing dipalmitoylphosphatidyl choline, the major lipid component of pulmonary surfactant that reduces surface tension in the alveoli to prevent collapse of the lungs at the end of expiration. ATII cells play an important role in innate immune responses within the lung with evidence that lung surfactant proteins have anti-microbial effects and reduce inflammation caused by the inhalation of irritants." ; rdfs:label "Abnormal alveolar type II pneumocyte morphology" ; rdfs:subClassOf obo:HP_0033137 . obo:HP_0033246 obo:IAO_0000115 "Increase in size of type II pneumocytes, characterized by qualitative morphologic alterations, including cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin." ; dc:date "2020-11-25T11:46:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypertrophic alveolar type II cells", "Hypertrophic alveolar type II pneumocytes" ; a owl:Class ; rdfs:label "Type II pneumocyte hypertrophy" ; rdfs:subClassOf obo:HP_0033245 . obo:HP_0033247 obo:IAO_0000115 "Extracellular deposition in lung tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding." ; dc:date "2020-11-25T14:09:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary amyloidosis" ; rdfs:subClassOf obo:HP_0006530, obo:HP_0011034 . obo:HP_0033248 obo:IAO_0000115 "Fibrosing nodules, consisting of either unilateral or bilateral central whorled deposits of lamellar collagen hyalin." ; dc:date "2020-11-25T14:12:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Multiple pulmonary interstitial hyalinized nodules" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033249 obo:IAO_0000115 "Hyperintense lesion in the substantia nigra on magnetic resonance T2 imaging." ; dc:date "2020-11-25T14:16:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal substantia nigra T2 hyperintense lesion" ; a owl:Class ; rdfs:label "Focal substantia nigra T2 hyperintensity" ; rdfs:subClassOf obo:HP_0045007 . obo:HP_0033250 obo:IAO_0000115 "An increased number of turns of the blood vessels of the nailfold with a charactereistic winded or twisted appearance of the blood vessels." ; dc:date "2020-11-25T14:19:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nailfold capillary tortuosity" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0033251 obo:IAO_0000115 "Increase in the amount of air remaining in a person's lungs after full exhalation." ; dc:date "2020-11-25T14:24:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated RV" ; a owl:Class ; rdfs:label "Elevated residual volume" ; rdfs:subClassOf obo:HP_0033752 . obo:HP_0033252 obo:IAO_0000115 "Exaggerated skin markings (dermatoglyphics) on the palms of the hand." ; dc:date "2020-11-27T19:22:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palmar hyperlinearity" ; rdfs:subClassOf obo:HP_0040211 . obo:HP_0033253 obo:IAO_0000115 "A reduction in the concentration of interferon gamma measured in the blood circulation." ; dc:date "2020-11-27T19:24:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced circulating interferon gamma" ; a owl:Class ; rdfs:label "Reduced circulating interferon gamma concentration" ; rdfs:subClassOf obo:HP_0030355 . obo:HP_0033254 obo:IAO_0000115 "Narrowing of the anorectum associated with inflammation or scar tissue." ; dc:date "2020-11-27T19:30:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stricture of the anorectum" ; a owl:Class ; rdfs:label "Anorectal stricture" ; rdfs:subClassOf obo:HP_0012732 . obo:HP_0033255 obo:IAO_0000115 "A congenital malformation characterized by an overdistended segment of lung, affecting an party of a lobe or the entire one. It results in progressive overinflation of one or more lobes." ; dc:date "2020-11-27T19:32:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Congenital lobar emphysema" ; a owl:Class ; rdfs:comment "Lobar overinflation is more commonly present in neonate or early infancy with life-threatening respiratory distress. The upper lobes are more frequently affected than the lower one. And more common in males (M:F = 3:1). On imaging, it classically presents on chest radiographs as a hyperlucent lung segment with overinflation and contralateral mediastinal shift." ; rdfs:label "Congenital lobar overinflation" ; rdfs:subClassOf obo:HP_0002101 . obo:HP_0033256 obo:IAO_0000115 "Inflammation of the entire colon." ; dc:date "2020-11-27T19:37:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pancolitis" ; rdfs:subClassOf obo:HP_0002583 . obo:HP_0033257 obo:IAO_0000115 "A failure to achieve the ability to walk with support (cruise) at an appropriate developmental stage." ; dc:date "2020-11-27T19:39:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Delayed ability to cruise" ; a owl:Class ; rdfs:label "Delayed ability to walk with support" ; rdfs:subClassOf obo:HP_0002194 . obo:HP_0033258 obo:IAO_0000115 "Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death." ; dc:date "2020-11-28T14:34:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "SUDEP" ; a owl:Class ; rdfs:label "Sudden unexpected death in epilepsy" ; rdfs:subClassOf obo:HP_0001699 . obo:HP_0033259 obo:IAO_0000115 "A seizure with clinical manifestation but without motor signs (other than possible behavior arrest) as its initial clinical manifestation. The electrographic onset may be generalized, focal, or unknown." ; dc:date "2020-11-28T14:43:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term may be used to code the non-motor seizures of a person who cannot confirm or exclude subjective seizure experiences that would aid more detailed classification as a generalized non-motor (absence) seizure or type of focal non-motor seizure." ; rdfs:label "Non-motor seizure" ; rdfs:subClassOf obo:HP_0001250 . obo:HP_0033260 obo:IAO_0000115 "Livedo racemosa describes a reddish-blue mottling of the skin in an irregular, reticular pattern. It differs from the more common livedo reticularis by its shape. Livedo racemosa consists of broken circular segments resulting in a seemingly larger pattern, as opposed to the fine, regular, complete network of livedo reticularis. Livedo racemosa results from permanent impairment of peripheral blood flow and, unlike livedo reticularis, it persists on warming." ; dc:date "2020-11-28T14:55:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Livedo racemosa" ; rdfs:subClassOf obo:HP_0033832 . obo:HP_0033261 obo:IAO_0000115 "Increase in diameter of a segment of the renal artery that can be defined as a focal, isolated dilatation of all three layers of the arterial wall over 1.5 times the diameter of the disease-free proximal adjacent arterial segment." ; dc:date "2020-11-28T14:56:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal artery aneurysm" ; rdfs:subClassOf obo:HP_0008776 . obo:HP_0033262 obo:IAO_0000115 "A fracture through the distal humeral physis that separates the entire distal humeral epiphysis from the metaphysis." ; dc:date "2020-11-28T15:04:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Transphyseal distal humerus fracture" ; a owl:Class ; rdfs:comment "Transphyseal fractures of the distal humerus typically occur in children younger than 3 years secondary to birth trauma, nonaccidental trauma, or a fall from a small height." ; rdfs:label "Transphyseal fracture of the distal humerus" ; rdfs:subClassOf obo:HP_0041055 . obo:HP_0033263 obo:IAO_0000115 "Lack of platelet dense granules, a type of platelet organelles." ; dc:date "2020-11-28T15:08:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent platelet dense bodies" ; a owl:Class ; rdfs:label "Absent platelet dense granules" ; rdfs:subClassOf obo:HP_0012530 . obo:HP_0033264 obo:IAO_0000115 "Increased size of platelet dense granules." ; dc:date "2020-11-28T15:12:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Enlarged platelet dense granules" ; rdfs:subClassOf obo:HP_0012484 . obo:HP_0033265 obo:IAO_0000115 "Lamellated intracytoplasmic lipid inclusions within podocytes." ; dc:date "2020-11-28T15:14:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Podocyte myelin inclusions" ; a owl:Class ; rdfs:label "Podocyte myelin figures" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033266 obo:IAO_0000115 "Visceral epithelial cell hyperplasia with resulting cellular crowding of the the urinary space. In contrast with true crescents, these proliferations lack inflammatory cells and fibrin. The cells are typically plump (not spindle-shaped) and often vacuolated, and Bowman's capsule is usually intact." ; dc:date "2020-11-28T15:19:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular pseudocrescent" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033267 obo:IAO_0000115 "Abnormal structural characteristics of the interior space of the capillary of the renal glomerulus." ; dc:date "2020-11-28T15:58:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular capillary lumen morphology" ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0033268 obo:IAO_0000115 "Wrinkling and folding of the capillaries without epithelial cell (podocyte) hyperplasia (formerly called ischemic type of collapse) involving o 80% of the glomerular tuft. The wrinkling is generally made by small regular folds of the glomerular basement membrane." ; dc:date "2020-11-28T16:01:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Deflation of the glomerular tuft" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033269 obo:IAO_0000115 "Collapse is generally accompanied by other descriptors such as hypertrophy and hyperplasia of overlying glomerular epithelial cells, halo, protein droplets in podocytes and glomerular parietal epithelial cells (PECs)." ; dc:date "2020-11-28T16:04:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Collapse of glomerular capillary walls" ; a owl:Class ; rdfs:comment "Wrinkling and folding of the glomerular basemement membrane (GBM) with partial or complete occlusion of the capillary lumen: wrinkling and folding of the GBM with partial or complete occlusion of the capillary lumen. The wrinkling is generally made by small and/or big irregular folds of the GBM." ; rdfs:label "Glomerular capillary collapse" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033270 obo:IAO_0000115 "Global distention of glomerular capillaries with intraluminal intact red blood cells." ; dc:date "2020-11-28T16:07:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glomerular congestion" ; a owl:Class ; rdfs:label "Glomerular capillary congestion" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033271 obo:IAO_0000115 "Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis." ; dc:date "2020-11-28T16:09:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular capillary microaneurysm" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033272 obo:IAO_0000115 "An abnormal structure of the glomerular endothelial cells, which are highly specialized cells with fenestrae and a charged luminal glycocalyx layer that contribute to the filtration barrier." ; dc:date "2020-11-28T16:20:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular endothelial cell morphology" ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0033273 obo:IAO_0000115 "Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm." ; dc:date "2020-11-28T16:22:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Loss of glomerular endothelial cell fenestration" ; rdfs:subClassOf obo:HP_0033272 . obo:HP_0033274 obo:IAO_0000115 "Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen." ; dc:date "2020-11-28T16:25:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular endotheliosis" ; rdfs:subClassOf obo:HP_0033272 . obo:HP_0033275 obo:IAO_0000115 "Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon." ; dc:date "2020-11-28T16:27:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular endothelial tubuloreticular inclusion" ; rdfs:subClassOf obo:HP_0033272 . obo:HP_0033276 dc:date "2020-11-28T16:29:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Glomerular endocapillary hypercellularity" ; owl:deprecated true . obo:HP_0033277 obo:IAO_0000115 "Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis." ; dc:date "2020-11-28T16:33:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular fibrinoid necrosis" ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0033278 obo:IAO_0000115 "Reduced amount of programmed cell death in peripheral blood lymphocytes following exposure to CD95 (APO-1/Fas), which is a member of the death receptor family, a subfamily of the TNF-R superfamily. Crosslinking of CD95 with its natural ligand CD95L (CD178) or with agonistic antibodies such as anti-APO-1 induces apoptosis in sensitive cells." ; dc:date "2020-11-28T17:19:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced CD95-induced lymphocyte apoptosis" ; rdfs:subClassOf obo:HP_0002731 . obo:HP_0033279 obo:IAO_0000115 "An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin." ; dc:date "2020-11-28T17:55:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Enterocutaneous fistula" ; rdfs:subClassOf obo:HP_0100819 . obo:HP_0033280 obo:IAO_0000115 "Enlargement of lymph nodes surrounding the trachea." ; dc:date "2020-11-28T18:19:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paratracheal lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0033281 obo:IAO_0000115 "The presence of nucleated red blood cells in the peripheral blood circulation." ; dc:date "2020-11-28T19:50:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Nucleated red blood cells (NRBCs) are early erythrocyte precursors not present in the peripheral blood of normal adults. Fenestrations in the bone marrow provide a physical filter to the release of the large NRBCs into the circulation, and the rare NRBC that escapes is rapidly cleared from peripheral blood by the spleen. The presence of circulating NRBCs in adults thus reflects extreme increases in erythropoietic activity or failure of the blood filtration mechanisms." ; rdfs:label "Circulating nucleated red blood cells" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0033282 obo:IAO_0000115 "Any abnormal sttructure of the glomerular basement membrane." ; dc:date "2020-11-28T20:24:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The (GBM) is an integral component of the glomerular filtration barrier; an important and highly complex capillary wall that is exposed to mechanical forces driven by capillary hydrostatic pressure. This barrier is permeable to water and small molecules, and selectively withholds cells and macromolecules such as albumin in the circulation." ; rdfs:label "Abnormal glomerular basement membrane morphology" ; rdfs:subClassOf obo:HP_0000095, obo:HP_0033603 . obo:HP_0033283 obo:IAO_0000115 "Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals." ; dc:date "2020-11-28T20:34:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Segmentally thickened glomerular basement membrane" ; rdfs:subClassOf obo:HP_0033285 . obo:HP_0033284 obo:IAO_0000115 "Prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals." ; dc:date "2020-11-28T20:36:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diffusely thickened glomerular basement membrane" ; rdfs:subClassOf obo:HP_0033285 . obo:HP_0033285 obo:IAO_0000115 "Prominent glomerular basement membrane (GBM) reflecting an increase in thickness (subjective estimate) with no evidence of electron dense deposits by electron microscopy." ; dc:date "2020-11-28T20:39:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thickened glomerular basement membranes with no electron dense deposits" ; rdfs:subClassOf obo:HP_0004722 . obo:HP_0033286 dc:date "2020-11-28T21:12:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thickened glomerular basement membranes with electron dense deposits" ; rdfs:subClassOf obo:HP_0004722 . obo:HP_0033287 obo:IAO_0000115 "Lucent zones within the glomerular basement membranes. May reflect remote/resolved deposits." ; dc:date "2020-11-28T21:13:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be observed on silver staining or electron microscopy." ; rdfs:label "Glomerular basement membrane lucencies" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033288 dc:date "2020-11-28T21:16:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Delicate, silver positive projections that extend at right angles from the glomerular basement membrane (GBM) out into the urinary space, creating an irregular GBM profile." ; rdfs:label "Glomerular basement membrane spikes" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033289 obo:IAO_0000115 "Irregular folding of the glomerular basement membrane with an intact lamina densa." ; dc:date "2020-11-28T21:18:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Wrinkling and folding of the glomerular basement membrane (GBM) without glomerular epithelial cell hypertrophy and hyperplasia (formerly known an ischemic type of collapse). The urinary space is patent. The wrinkling is generally made by small regular infoldings of the GBM." ; rdfs:label "Glomerular basement membrane wrinkling" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033290 obo:IAO_0000115 "Expansion of the space between the glomerular endothelium and lamina densa by electron-lucent material." ; dc:date "2020-11-28T21:22:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular subendothelial widening" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033291 obo:IAO_0000115 "Apoptotic, pyknotic, and fragmented nuclei within the glomerulus." ; dc:date "2020-11-28T21:25:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular karyhorrhectic debris" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033292 obo:IAO_0000115 "An aggregate of coagulated blood containing fibrin, with or without entrapped cellular elements, within a glomerular capillary lumen." ; dc:date "2020-11-28T21:27:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular fibrin thrombus" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033293 obo:IAO_0000115 "Intracapillary amorphous, eosinophilic material consisting of immune deposits." ; dc:date "2020-11-28T21:29:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular hyaline pseudothrombus" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033294 obo:IAO_0000115 "Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections." ; dc:date "2020-11-28T21:30:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular lipoprotein thrombus" ; rdfs:subClassOf obo:HP_0033267 . obo:HP_0033295 obo:IAO_0000115 "Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit." ; dc:date "2020-11-28T21:33:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial Immune complex deposition" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033296 obo:IAO_0000115 "Visceral epithelial cells with 2 nuclei. Can be observed on light or ultrastructral microscopy." ; dc:date "2020-11-28T21:35:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Binucleated podocytes" ; a owl:Class ; rdfs:label "Binucleated visceral epithelial cells" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033297 obo:IAO_0000115 "Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy." ; dc:date "2020-11-28T21:38:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multinucleated podocytes", "Podocyte multinucleation" ; a owl:Class ; rdfs:label "Multinucleated visceral epithelial cells" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033298 obo:IAO_0000115 "A deviation from the normal concentration in blood of factor H-related protein 1 (FHR-1)" ; dc:date "2020-11-28T21:49:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for binding to C3b, and may act as an antagonist of CFH-directed regulation on cell surfaces." ; rdfs:label "Abnormal circulating complement factor H related protein 1 concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033299 obo:IAO_0000115 "Decreased level of circulating complement factor H related protein 1 concentration in the blood circulation." ; dc:date "2020-11-28T21:57:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating complement factor H related protein 1 concentration" ; rdfs:subClassOf obo:HP_0033298 . obo:HP_0033300 obo:IAO_0000115 "Elevated level of circulating complement factor H related protein 1 concentration in the blood circulation." ; dc:date "2020-11-28T21:57:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating complement factor H related protein 1 concentration" ; rdfs:subClassOf obo:HP_0033298 . obo:HP_0033301 obo:IAO_0000115 "An abnormally increased level of 1-methylhistidine in the blood circulation. 1-methylhistidine is a derivative of L-histidine." ; dc:date "2020-11-28T22:00:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating 1-methylhistidine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0033302 obo:IAO_0000115 "The concentration of 4-Hydroxyphenylacetic acid in the blood circulation is above the upper limit of normal." ; dc:date "2020-11-28T22:03:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "4-hydroxyphenlyllactic acid is a human metabolite that derives from an acetic acid." ; rdfs:label "Elevated circulating 4-hydroxyphenylacetic acid concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0033303 obo:IAO_0000115 "Abnormally increased amount of a monocarboxylic acid in the urine. Monocarboxylic acids are molecules with one COOH functional group." ; dc:date "2020-11-28T22:06:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary monocarboxylic acid level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0033304 obo:IAO_0100001 "HP:0003607" ; dc:date "2020-11-28T22:07:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Elevated urine 4-hydroxyphenylacetic acid level" ; owl:deprecated true . obo:HP_0033305 obo:IAO_0000115 "Any deviation from the normal concentration of fetuin A in the blood circulation." ; dc:date "2020-11-28T22:09:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fetuin-A (FetA) is a 64-kDa glycoprotein that is found in relatively high concentrations in human serum. In human adults, FetA is mainly expressed and secreted from the liver and adipose tissue. Epidemiologic research consistently observes elevated circulating FetA in obesity and related complications, such as type 2 diabetes mellitus, the metabolic syndrome, and nonalcoholic fatty liver disease." ; rdfs:label "Abnormal circulating fetuin A concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033306 obo:IAO_0000115 "A reduction below normal of fetuin A in the blood circulation." ; dc:date "2020-11-28T22:12:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating fetuin A concentration" ; rdfs:subClassOf obo:HP_0033305 . obo:HP_0033307 obo:IAO_0000115 "An elevation above normal of fetuin A in the blood circulation." ; dc:date "2020-11-28T22:12:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating fetuin A concentration" ; rdfs:subClassOf obo:HP_0033305 . obo:HP_0033308 obo:IAO_0000115 "Excessive growth of the kneecap (patella)." ; dc:date "2020-11-28T22:15:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Patellar overgrowth" ; rdfs:subClassOf obo:HP_0003045 . obo:HP_0033309 obo:IAO_0000115 "A type of intussusception of the small intestine in which one part of the ileum invaginates (telescopes) into another part of the ileum." ; dc:date "2020-11-28T22:16:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ileoileal intussusception" ; rdfs:subClassOf obo:HP_0002576 . obo:HP_0033310 obo:IAO_0000115 "Osmotic diarrhea results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption." ; dc:date "2020-11-28T22:20:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Osmotic diarrhea involves an unabsorbed substance that draws water from the plasma into the intestinal lumen along osmotic gradients. Secretory diarrhea results from disordered electrolyte transport and, despite the term, is more commonly caused by decreased absorption rather than net secretion. Inflammatory diseases cause diarrhea with exudative, secretory, or osmotic components." ; rdfs:label "Osmotic diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0033311 obo:IAO_0000115 "A tear in the intimal layer of the abdominal aorta causing a separation between the intima and the medial layers." ; dc:date "2020-11-28T22:39:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abdominal aortic dissection" ; rdfs:subClassOf obo:HP_0002647 . obo:HP_0033312 obo:IAO_0000115 "Structural anomaly located in Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron." ; dc:date "2020-11-29T13:07:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bowman's capsule is a part of the nephron that forms a cup-like sack surrounding the glomerulus. The capsule encloses a space called Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron. Bowman's capsule, Bowman's space, and the glomerular capillary network and its supporting architecture can collectively be thought of as composing the glomerulus." ; rdfs:label "Abnormal Bowman space morphology" ; rdfs:subClassOf obo:HP_0031264 . obo:HP_0033313 obo:IAO_0000115 "Acellular collagenous matrix within Bowman's space, not associated with extracapillary hypercellularity or necrosis, associated with sclerosis or deflation of the tuft." ; dc:date "2020-11-29T13:10:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Collagenization of the urinary space" ; a owl:Class ; rdfs:label "Urinary space collagenization" ; rdfs:subClassOf obo:HP_0033312 . obo:HP_0033314 obo:IAO_0000115 "Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium." ; dc:date "2020-11-29T13:17:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyperplasia of visceral epithelial cells", "Podocyte hyperplasia" ; a owl:Class ; rdfs:label "Visceral epithelial cell hyperplasia" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033315 obo:IAO_0000115 "Round to ovoid, Periodic acid-Schiff (PAS)-positive, fuchsinophilic cytoplasmic inclusions within visceral epithelial cells." ; dc:date "2020-11-29T13:22:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Visceral epithelial hyaline droplets" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033316 obo:IAO_0000115 "Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin." ; dc:date "2020-11-29T13:27:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The crescent is an unspecific histopathological lesion that can be triggered by a variety of different underlying disorders. Whenever, microvascular injury leads to rupture of the glomerular basement membrane (GBM), the leakage of plasma proteins drives parietal epithelial cell hyperplasia as the key cellular component of the crescent. Single nephron GFR decreases because of tuft collapse, rupture of the Bowman capsule, and influx of immune cells and fibroblasts are all secondary events that may or may not occur in individual glomeruli. Periglomerular immune cell infiltrates or fibrotic encasting of the activated parietal cells (fibrocellular crescents) are subsequent events that may affect the dynamics and prognosis of the disease." ; rdfs:label "Glomerular crescent formation" ; rdfs:subClassOf obo:HP_0033312 . obo:HP_0033317 obo:IAO_0000115 "A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix." ; dc:date "2020-11-29T13:31:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cellular crescent" ; rdfs:subClassOf obo:HP_0033316 . obo:HP_0033318 obo:IAO_0000115 "A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix." ; dc:date "2020-11-29T13:33:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrocellular crescent" ; rdfs:subClassOf obo:HP_0033316 . obo:HP_0033319 obo:IAO_0000115 "A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference." ; dc:date "2020-11-29T13:37:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrous crescent" ; rdfs:subClassOf obo:HP_0033316 . obo:HP_0033320 obo:IAO_0000115 "Loss of mesangial cells segmentally or globally." ; dc:date "2020-11-29T13:43:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mesangial cell loss can be observed in the setting of mesangiolysis." ; rdfs:label "Mesangial cell loss" ; rdfs:subClassOf obo:HP_0033231 . obo:HP_0033321 obo:IAO_0000115 "Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium." ; dc:date "2020-11-29T13:57:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular obsolescence" ; rdfs:subClassOf obo:HP_0004737 . obo:HP_0033322 obo:IAO_0000115 "Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM." ; dc:date "2020-11-29T13:59:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular capillary wall duplication without cellular interposition" ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0033323 obo:IAO_0000115 "Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM." ; dc:date "2020-11-29T14:01:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular capillary wall duplication with cellular interposition" ; rdfs:subClassOf obo:HP_0025006 . obo:HP_0033324 obo:IAO_0000115 "The concentration of homovanillic acid in the blood circulation is above the upper limit of normal." ; dc:date "2020-11-29T14:09:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Homovanillic acid is the main metabolite produced from dopamine degradation by the action of monoamine oxidase." ; rdfs:label "Elevated circulating homovanillic acid concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0033325 obo:IAO_0000115 "Increased concentration of sebacic acid in the blood circulation." ; dc:date "2020-11-29T14:11:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating sebacic acid concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0033326 obo:IAO_0000115 "An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation." ; dc:date "2020-11-29T14:16:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hydroxyphenyllactic acid or 4-hydroxyphenyllactate (the L-form) is a tyrosine metabolite. The level of L-hydroxyphenyllactic acid is elevated in patients with a deficiency of the enzyme p-hydroxyphenylpyruvate oxidase." ; rdfs:label "Elevated circulating hydroxyphenlyllactic acid concentration" ; rdfs:subClassOf obo:HP_0004354 . obo:HP_0033327 obo:IAO_0000115 "Psoriatic nail abnormality characterized by the presence of neutrophils in the nail bed epithelium, hyperkeratosis with parakeratosis, presence of exudates on the corneal epithelium, focal hypogranulosis and psoriasiform hyperplasia of the nail bed." ; dc:date "2020-11-29T14:25:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The prevalence of nail involvement in individuals with psoriasis is approximately 50%, with even higher prevalnce in individuals with psoriatic arthritis." ; rdfs:label "Nail psoriasis" ; rdfs:subClassOf obo:HP_0001597 . obo:HP_0033328 obo:IAO_0000115 "Increase in the number of type II pneumocytes." ; dc:date "2020-11-29T15:29:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Type II pneumocyte hyperplasia" ; rdfs:subClassOf obo:HP_0033245 . obo:HP_0033329 obo:IAO_0000115 "Anomaly of the physiological response to maintain the body's posture when movement and position is altered." ; dc:date "2020-11-29T16:11:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal postural reaction" ; a owl:Class ; rdfs:comment "The primitive reflexes and the postural reactions comprise one of the earliest, simplest, and most frequently used tools among child neurologists to assess the central nervous system integrity of infants and young children. Infants with cerebral palsy have been known to manifest persistence or delay in the disappearance of primitive reflexes and pathologic or absent postural reactions. Primitive reflexes develop prenatally, are present at birth in the full-term neonate. Postural reflexes emerge after birth and take up to three and a half years to be fully developed." ; rdfs:label "Abnormal postural reflex" ; rdfs:subClassOf obo:HP_0031826 . obo:HP_0033330 obo:IAO_0000115 "Abnormal neck-righting response, which is said to be a physiological response when a child is placed flat on his or her back and the head is turned 90 degrees to the right or the left. With a normal neck-righting response, there follows a reflected torsion of the vertebral column in the same direction as the induced rotation of the neck. That is, the whole body follows the direction in which the head was turned. The response is present from birth to the age of five years." ; dc:date "2020-11-29T16:23:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired neck-righting reflex" ; rdfs:subClassOf obo:HP_0033329 . obo:HP_0033331 obo:IAO_0000115 "Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing." ; dc:date "2020-11-29T16:35:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acute phase response" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0033332 obo:IAO_0000115 "An increased concentration of serum amyloid A in the blood circulation." ; dc:date "2020-11-29T16:37:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating amyloid A" ; rdfs:subClassOf obo:HP_0010876, obo:HP_0033331 . obo:HP_0033333 obo:IAO_0000115 "Limitation of motion of the jaw due to structural changes in a muscle such as the massseter responsible for jaw movement." ; dc:date "2020-11-29T16:42:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Jaw contracture" ; rdfs:subClassOf obo:HP_0001371, obo:HP_0030791 . obo:HP_0033334 obo:IAO_0000115 "An anomaly in the development of the embryo, that is, of the early developmental stage of development that follows the fertilization of an egg by sperm." ; dc:date "2020-11-29T17:48:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal embryonic development" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0033335 obo:IAO_0000115 "An anomaly in the development of the embryo in a stage prior to implantation." ; dc:date "2020-11-29T17:49:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Human embryo development begins in relative transcriptional silence with an oocyte to embryo transition that lasts for about 3 days and encompasses fusion of the egg and sperm, migration and fusion of the germ cell pronuclei, genetic and epigenetic reprogramming. The embryo subsequently undergoes compaction to form a morula that marks the first morphological indication of a break in radial symmetry. Subsequent cell divisions lead to the development of a blastocyst that comprises a fluid-filled blastocyst cavity and an inner cell mass, surrounded by trophectoderm cells. Implantation, which in humans occurs at approximately day 7 of development, is required for further development of the embryo proper." ; rdfs:label "Abnormal preimplantation embryonic development" ; rdfs:subClassOf obo:HP_0033334 . obo:HP_0033336 obo:IAO_0000115 "Failure of a fertilized oocyte to undergo the first round of cell division." ; dc:date "2020-11-29T17:54:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Failure of zygotic cell division" ; a owl:Class ; rdfs:comment "A zygote undergoes rapid cell divisions referred to as cleavage because they are not are not associated with significant growth of the embryo. The iniital round of cleavage forms a spherical ball of cells called the blastula, which then develops into a blastocyst." ; rdfs:label "Zygotic cleavage failure" ; rdfs:subClassOf obo:HP_0033335 . obo:HP_0033337 obo:IAO_0000115 "An anomaly in the process by a a haploid cell is formed from a diploid cells through meiosis. In males, diploid spermatogonia produce two haploid cells (secondary spermatocytes) in meiosis I and four haploid spermatids in meiosis II. In females, primordial germ cells under meiosis II before birth to form primary oocytes. Once puberty cell begins, these cells form secondary oocytes through meiosis II." ; dc:date "2020-11-29T18:23:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal gametogenesis" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0033338 obo:IAO_0000115 "Anomalous oocyte meiosis" ; dc:date "2020-11-29T18:29:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal female meiosis" ; rdfs:subClassOf obo:HP_0031515 . obo:HP_0033339 obo:IAO_0000115 "An increased concentration of inosine in the blood circulation." ; dc:date "2020-11-29T19:04:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond." ; rdfs:label "Increased circulating inosine concentration" ; rdfs:subClassOf obo:HP_0004368 . obo:HP_0033340 obo:IAO_0000115 "Increased concentration of guanosine in the blood circulation." ; dc:date "2020-11-29T19:06:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating guanosine concentration" ; rdfs:subClassOf obo:HP_0004368 . obo:HP_0033341 obo:IAO_0000115 "An increased concentration of beta-sitosterol in the blood circulation." ; dc:date "2020-11-30T12:46:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating beta-sitosterol concentration" ; a owl:Class ; rdfs:comment "Sitosterol (also known as beta-sitosterol) is a phytosterols with a chemical structure similar to that of cholesterol." ; rdfs:label "Elevated circulating sitosterol concentration" ; rdfs:subClassOf obo:HP_0003119 . obo:HP_0033342 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against aquaporin-4." ; dc:date "2020-11-30T12:48:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-AQP4 antibody positivity" ; a owl:Class ; rdfs:label "Anti-aquaporin 4 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033343 obo:IAO_0000115 "Passage of an increased number of stools containing mucus, a thick fluid substance secreted by mucous membranes." ; dc:date "2020-11-30T14:20:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mucous diarrhea", "Mucous diarrhoea" ; a owl:Class ; rdfs:label "Mucoid diarrhea" ; rdfs:subClassOf obo:HP_0002014 . obo:HP_0033344 obo:IAO_0000115 "A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura." ; dc:date "2020-11-30T17:44:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleural cobblestoning" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033345 obo:IAO_0000115 "Pain (An unpleasant sensory and emotional experience) along the course of a nerve." ; dc:date "2020-11-30T17:57:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neuralgia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0033346 obo:IAO_0000115 "Aura with affective, mnemonic or composite perceptual phenomena including illusory or composite hallucinatory events." ; dc:date "2020-11-30T21:09:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Psychic aura" ; a owl:Class ; rdfs:comment "Events may appear alone or in combination. Included are feelings of depersonalization. These phenomena have subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context." ; rdfs:label "Psychic epileptic aura" ; rdfs:subClassOf obo:HP_0033348 . obo:HP_0033347 obo:IAO_0000115 "A purely subjective manifestation of an epileptic seizure pertaining to altered cognition." ; dc:date "2020-11-30T21:47:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cognitive epileptic aura" ; rdfs:subClassOf obo:HP_0033346 . obo:HP_0033348 obo:IAO_0000115 "An epileptic aura is a purely subjective clinical manifestation of an epileptic seizure. If an epileptic aura is not followed by loss of awareness or propagation to a bilateral tonic-clonic seizure then it is a type of focal aware non-motor seizure." ; dc:date "2020-11-30T21:50:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Epileptic aura" ; rdfs:subClassOf obo:HP_0032679 . obo:HP_0033349 obo:IAO_0000115 "A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient." ; dc:date "2020-11-30T22:08:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acute repetitive seizures", "Crescendo seizures", "Cyclical seizures", "Recurrent seizures", "Seizure flurries", "Serial seizures" ; a owl:Class ; rdfs:comment "This term should be used with an HPO term for the appropriate type of seizure to denote clustered occurence of seizures. There is no consensus within the medical community regarding the definition of a seizure cluster, where limitations of current clinical definitions include poor sensitivity and specificity. The proposed definition is meant to serve as a placeholder until a more robust definition, likely facilitated by technological advances in seizure tracking devices and personalised cluster identification is agreed upon." ; rdfs:label "Seizure cluster" ; rdfs:subClassOf obo:HP_0031796 . obo:HP_0033350 obo:IAO_0000115 "An increase in the amount of air a person can forcefully expel in one second, compared to some standard or previous measure of same subject." ; dc:date "2020-11-30T22:24:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated FEV1" ; a owl:Class ; rdfs:label "Elevated forced expiratory volume in one second" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033351 obo:IAO_0000115 "Candida infections of the esophagus are considered opportunistic infections and are seen most commonly in immunosuppressed patients, the most common symptoms being dysphagia, odynophagia, and retrosternal pain." ; dc:date "2020-11-30T22:27:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Esophageal candidiasis" ; a owl:Class ; rdfs:label "Candida esophagitis" ; rdfs:subClassOf obo:HP_0032255 . obo:HP_0033352 obo:IAO_0000115 "Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output." ; dc:date "2020-11-30T22:31:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary arterial hypertension crisis" ; a owl:Class ; rdfs:label "Pulmonary hypertensive crisis" ; rdfs:subClassOf obo:HP_0004890 . obo:HP_0033353 obo:IAO_0000115 "Any structural anomaly of a blood vessel (artery, arteriole, capillary, venule, or vein)." ; dc:date "2020-12-01T11:42:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal blood vessel morphology" ; rdfs:subClassOf obo:HP_0025015 . obo:HP_0033354 obo:IAO_0000115 "Any deviation from the normal amount of a metabolite in urine." ; dc:date "2020-12-01T12:00:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "As water reabsorption in kidneys affect urinary solute concentrations, various methods are applied to normalize the measured concentration. Frequently, concentrations are reported as a ratio to urinary creatinine. The HPO terms in this subhierarchy therefore use the word 'level' to indicate that appropriate normalization has been performed before concluding that the amount of the indicated metabolite is abnormal." ; rdfs:label "Abnormal urine metabolite level" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0033355 obo:IAO_0000115 "An increased level of deoxypyridinoline in the urine. Deoxypyridinoline is a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, has been described as a marker of bone turnover." ; dc:date "2020-12-01T12:09:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urinary DPD" ; a owl:Class ; rdfs:label "Increased urine deoxypyridinoline level" ; rdfs:subClassOf obo:HP_0033384 . obo:HP_0033356 obo:IAO_0000115 "An abnormally increased level of o-phosphoserine in the blood circulation. o-phosphoserine is a derivative of serine." ; dc:date "2020-12-01T12:16:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating o-phosphoserine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0033357 obo:IAO_0000115 "Reduced range of motion turning the head side to side." ; dc:date "2020-12-01T12:37:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Limited head rotation" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0033358 obo:IAO_0000115 "A deviation from the normal range of concentration of particles in urine." ; dc:date "2020-12-01T12:44:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urine osmolality" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0033359 obo:IAO_0000115 "An abnormally high urinary specific gravity, i.e., increased concentration of solutes in the urine." ; dc:date "2020-12-01T12:45:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperosthenuria" ; rdfs:subClassOf obo:HP_0033358 . obo:HP_0033360 obo:IAO_0000115 "A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible." ; dc:date "2020-12-02T20:43:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired task shifting" ; a owl:Class ; rdfs:label "Impaired ability to shift attention" ; rdfs:subClassOf obo:HP_0033051 . obo:HP_0033361 obo:IAO_0000115 "An open sore of the nasal mucosa." ; dc:date "2020-12-02T21:00:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Nasal ulcers may occur due exogenous factors, such as trauma, pressure or inhalation of metals dust or aerosol. Nasal ulcers may also be a sign of an underlying disease, for example malignancies, infections (tuberculosis, leprosy, leishmaniasis), vasculitis (Wegener's granulomatosis, Churg-Strauss syndrome) or systemic lupus erythematosus." ; rdfs:label "Nasal ulcer" ; rdfs:subClassOf obo:HP_0000433 . obo:HP_0033362 obo:IAO_0000115 "Repeated occurrence of episodes of coughing, with each episode consisting of at least five minutes of continuous coughing." ; dc:date "2020-12-16T11:33:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent coughing spasms" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0033363 obo:IAO_0000115 """Hyaline membranes are homogeneous eosinophilic material composed of cellular debris, plasma proteins, and surfactant plastered against alveolar ducts and alveolar walls. The hyaline membranes are deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.""" ; dc:date "2020-12-16T11:36:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyaline membranes" ; rdfs:subClassOf obo:HP_0033137 . obo:HP_0033364 obo:IAO_0000115 "A specific form of lung inflammation that results from accumulation of lipids in the alveoli. Lipoid pneumonia can be either exogenous or endogenous in cause based on the source of the lipid." ; dc:date "2020-12-16T11:45:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lipoid pneumonia" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033365 obo:IAO_0000115 "A type of lipoid pneumonia in which the source of the lipids is the body itself. When an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace." ; dc:date "2020-12-16T11:45:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Endogenous lipoid pneumonia is a histopathologic diagnosis made on the basis of the characteristic appearance of the obstructive pneumonitis. Macroscopically, there is parenchymal consolidation that has a characteristic yellowish discoloration due to the accumulation of lipid in the alveoli. Histologically, there is an accumulation of lipid-filled macrophages and eosinophilic proteinaceous material derived from degenerating cells, including surfactant from type II pneumocytes, in the alveoli distal to the bronchial obstruction." ; rdfs:label "Endogenous lipoid pneumonia" ; rdfs:subClassOf obo:HP_0033364 . obo:HP_0033366 obo:IAO_0000115 "A type of lipoid pneumonia in which the source of the lipids is external to the body." ; dc:date "2020-12-16T11:50:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Endogenous lipoid pneumonia is a histopathologic diagnosis made on the basis of the characteristic appearance of the obstructive pneumonitis. Macroscopically, there is parenchymal consolidation that has a characteristic yellowish discoloration due to the accumulation of lipid in the alveoli. Histologically, there is an accumulation of lipid-filled macrophages and eosinophilic proteinaceous material derived from degenerating cells, including surfactant from type II pneumocytes, in the alveoli distal to the bronchial obstruction." ; rdfs:label "Exogenous lipoid pneumonia" ; rdfs:subClassOf obo:HP_0033364 . obo:HP_0033367 obo:IAO_0000115 "Low level of blood oxygen induced by changing from a recumbent to an upright position." ; dc:date "2020-12-16T11:53:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orthodeoxia" ; rdfs:subClassOf obo:HP_0012418 . obo:HP_0033368 obo:IAO_0000115 "A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position." ; dc:date "2020-12-16T11:55:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Platypnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0033369 obo:IAO_0000115 "A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity." ; dc:date "2020-12-16T12:10:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cavitating leukodystrophy" ; rdfs:subClassOf obo:HP_0002415 . obo:HP_0033370 obo:IAO_0000115 "Telangiectasias (small dilated blood vessels located near the surface of the skin or mucous membranes) located in the trachoebronchial system." ; dc:date "2020-12-16T12:36:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endobronchial telangiectasia" ; a owl:Class ; rdfs:comment "Endobronchial telangiectasia may lead to hemoptysis and pulmonary hemorrhage." ; rdfs:label "Bronchial telangiectasia" ; rdfs:subClassOf obo:HP_0004930, obo:HP_0100579 . obo:HP_0033371 obo:IAO_0000115 "Granulomatous inflammation that surrounds the bronchi and bronchioles, replacing bronchial walls and mucosa. In bronchocentric granulomatosis, the lumen of the airway contains necrotic debris, and palisaded histiocytes surround the lumen." ; dc:date "2020-12-16T12:59:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is shown in Figure 2 of PMID:26744680." ; rdfs:label "Bronchocentric granulomatosis" ; rdfs:subClassOf obo:HP_0030250 . obo:HP_0033372 obo:IAO_0000115 "Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O." ; dc:date "2020-12-23T12:36:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The carbon monoxide transfer coefficient (KCO is approximately kCO/barometric pressure in mL/minute/ mmHg/L) is often written as DLCO/VA. It is an index of the efficiency of alveolar transfer of carbon monoxide." ; rdfs:label "Abnormal KCO" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033373 obo:IAO_0000115 "Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index)." ; dc:date "2020-12-23T12:40:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased KCO" ; rdfs:subClassOf obo:HP_0033372 . obo:HP_0033374 obo:IAO_0000115 "Decreased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index)." ; dc:date "2020-12-23T12:41:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased KCO" ; rdfs:subClassOf obo:HP_0033372 . obo:HP_0033375 obo:IAO_0000115 "Anthracosis is the deposition of black carbon pigment. It is commonly seen in perihilar lymph nodes as well as within lung parenchyma. There can be prominent storiforming (i.e., spiral patterning) of histiocytes, to such an extent as to mimic a neoplastic lesion histologically. Anthracosis is a common finding in smokers and polluted city dwellers." ; dc:date "2020-12-23T12:44:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 15.11 in PMCID:PMC7262960." ; rdfs:label "Anthracosis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033376 obo:IAO_0000115 "Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology." ; dc:date "2020-12-23T13:39:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alveolar septal thickening" ; rdfs:subClassOf obo:HP_0033137 . obo:HP_0033377 obo:IAO_0000115 "Presence of increased numbers of bombesin-immuno-positive neuroendocrine cells (NECs) within distal airways. There are no formal criteria for an increase (which is also dependend on the sensitivity of the staining method), findings of neuroendocrine cells in at least 70% of bronchioles by lung biopsy and at least 10% NECs in an individual airway are consistent with the diagnosis of Neuroendocrine cell hyperplasia of infancy in the appropriate clinical setting. Increases are also seen in other clicnial settings. Neuroendocrine neoplasms of the lung encompass NE tumors (NETs), which split into typical and atypical carcinoids, and NE carcinomas (NECs)." ; dc:date "2020-12-23T14:03:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment """The bronchial mucosa also contains a small cluster of neuroendocrine cells, also known as Kulchitsky cells. They have neurosecretory type granules and can secrete several factors. This includes catecholamine and polypeptide hormones, such as serotonin, calcitonin, and gastrin-releasing factors (bombesin). Like brush cells, these neuroendocrine cells make up only a small portion of mucosal epithelium, around 3%. Pulmonary neuroendocrine cells (NECs), which produce bioactive products, including bombesin-like peptide and serotonin, are specialized epithelial cells scattered throughout the conducting airways and as innervated clusters (neuroepithelial bodies [NEBs]). In the fetus, NECs are most abundant in the distal airways where they promote branching morphogenesis, epithelial and mesenchymal cell proliferation, and surfactant secretion. Postnatally, NECs function as oxygen chemosensors and degranulate in response to hypoxia. Although NECs decline rapidly in number after the neonatal period, NEC hyperplasia has been described in a number of conditions or disorders, including bronchopulmonary dysplasia, sudden infant death syndrome, pulmonary hypertension, cystic fibrosis, and mechanical ventilation.""" ; rdfs:label "Increased airway neuroendocrine cells" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033378 obo:IAO_0000115 "Presence of increased numbers of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts." ; dc:date "2020-12-23T14:10:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased airway neuroepithelial bodies" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033379 obo:IAO_0000115 "The presence of a left and a right superior vena cava." ; dc:date "2020-12-23T14:20:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bilateral SVC" ; a owl:Class ; rdfs:comment "The thoracic embryonic venous system is composed of two large veins (the superior cardinal veins) which return blood from cranial aspect of embryo, and the inferior cardinal vein, which returns blood from the caudal aspect. Both pairs of veins join to form right and left common cardinal veins before entering the embryological heart. The left common cardinal vein persists to form coronary sinus and oblique vein of left atrium. During the 8th week of gestation, an anastomosis forms between right and left superior cardinal veins resulting in the innominate (or brachiocephalic) vein. The cephalic portion of superior cardinal veins form the internal jugular veins. The caudal portion of right superior vein forms the normal right-sided superior vena cava, while the portion of the left superior cardinal vein caudal to the innominate vein normally regresses to become the ligament of Marshall. If this normal regression of the left superior cardinal vein fails to occur, a persistent left-sided vascular structure that empties into the coronary sinus, results (Persistent left superior vena cava or PLSVC). The innominate vein may or may not degenerate in these cases leading to variations in anatomy. The most common subtype of PLSVC results in the presence of both left and right SVCs (Bilateral SVC). A bridging innominate vein may or may not be present." ; rdfs:label "Bilateral superior vena cava" ; rdfs:subClassOf obo:HP_0005301 . obo:HP_0033380 obo:IAO_0000115 "Inflammation of the cartilage of the nose." ; dc:date "2020-12-23T14:31:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Nose chondritis" ; a owl:Class ; rdfs:label "Nasal chondritis" ; rdfs:subClassOf obo:HP_0100662, obo:HP_3000034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003407 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033381 obo:IAO_0000115 "Abnormally increased concentration of O-stearoylcarnitine in the blood circulation." ; dc:date "2020-12-23T14:47:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Stearoylcarnitine (CHEBI:73074) is known by several names including O-stearoylcarnitine and stearoylcarnitine (C18)." ; rdfs:label "Elevated circulating stearoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0012071 . obo:HP_0033382 obo:IAO_0000115 "Abnormally increased concentration of palmitoylcarnitine in the blood circulation." ; dc:date "2020-12-23T15:05:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Palmitoylcarnitine (CHEBI:73067) is also known as O-palmitoylcarnitine and O-hexadecanoylcarnitine." ; rdfs:label "Elevated circulating palmitoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0012071 . obo:HP_0033383 obo:IAO_0000115 "Reduced level of the compound muscle action potential (CMAP), which is recorded following electrical stimulation of a nerve from surface electrodes overlying a muscle supplied by that nerve." ; dc:date "2021-01-02T12:41:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased CMAP amplitude" ; a owl:Class ; rdfs:comment "The CMAP is a summated voltage response from the individual muscle fibre action potentials. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV)." ; rdfs:label "Decreased compound muscle action potential amplitude" ; rdfs:subClassOf obo:HP_0030179 . obo:HP_0033384 obo:IAO_0000115 "Increased level in the urine of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease." ; dc:date "2021-01-02T13:26:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bone undergoes continuous remodeling because of the activity of osteoblasts (bone formation) and osteoclasts (bone resorption). Collagen degradation products may be considered as biochemical markers of bone resorption." ; rdfs:label "Elevated urinary collagen degradation products" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0033385 obo:IAO_0000115 "An increased amount of pyridinoline in the urine." ; dc:date "2021-01-02T13:31:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urine hydroxylysyl-pyridinoline level" ; a owl:Class ; rdfs:comment "The urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) and hydroxylysyl-pyridinoline (HP, or pyridinoline PYD) are biochemical markers of osteoclastic bone resorption and collagen degradation. Pyridinolines are formed during fibril formation of type I and type II collagen in the extracellular matrix. Some lysyl- and hydroxylysyl-residues in distinct positions in the collagen triple-helix and in the telopeptides of the tropocollagen are oxidised by lysyl oxidase. Subsequently three of these residues are covalently linked thereby interconnecting tropocollagen molecules and stabilizing the collagen matrix. When bone collagen is degraded, pyridinolines remain as stable degradation products and are secreted with the urine." ; rdfs:label "Elevated urine pyridinoline level" ; rdfs:subClassOf obo:HP_0033384 . obo:HP_0033386 obo:IAO_0000115 "Abnormal concentration in the blood circulation of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease." ; dc:date "2021-01-02T13:34:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating collagen degradation product concentration" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0033387 obo:IAO_0000115 "An increased concentration of hydroxylysyl-pyridinoline (pyridinoline) in the blood circulation." ; dc:date "2021-01-02T13:36:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) and hydroxylysyl-pyridinoline (HP, or pyridinoline PYD) are established biochemical markers of osteoclastic bone resorption and collagen degradation. Pyridinolines are formed during fibril formation of type I and type II collagen in the extracellular matrix. Some lysyl- and hydroxylysyl-residues in distinct positions in the collagen triple-helix and in the telopeptides of the tropocollagen are oxidised by lysyl oxidase. Subsequently three of these residues are covalently linked thereby interconnecting tropocollagen molecules and stabilizing the collagen matrix. When bone collagen is degraded, pyridinolines remain as stable degradation products and are secreted with the urine. Depending on whether or not these lysyl residues had been hydroxylated prior to crosslinking, lysyl-pyridinoline (LP) or hydroxylysyl-pyridinoline (HP) is generated." ; rdfs:label "Elevated circulating pyridinoline concentration" ; rdfs:subClassOf obo:HP_0033386 . obo:HP_0033388 obo:IAO_0000115 "Any structural abnormality of a bronchial artery." ; dc:date "2021-01-06T12:20:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The bronchial arteries originate from the systemic circulation and supply the lungs with oxygenated blood." ; rdfs:label "Abnormal bronchial artery morphology" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0033389 obo:IAO_0000115 "Abnormal arterial anastomosis (connection) between bronchial and pulmonary arteries." ; dc:date "2021-01-06T12:23:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchopulmonary anastomosis" ; rdfs:subClassOf obo:HP_0030966, obo:HP_0033388 . obo:HP_0033390 obo:IAO_0000115 "Increased caliber of a bronchial artery, which can be defined as a bronchial artery diameter that exceeds 2 mm." ; dc:date "2021-01-06T12:25:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bronchial artery enlargement", "Dilatation of a bronchial artery" ; a owl:Class ; rdfs:label "Bronchial artery dilatation" ; rdfs:subClassOf obo:HP_0033388 . obo:HP_0033391 obo:IAO_0000115 "Increase in the volume of bronchial artery wall due to the enlargement of its component cells." ; dc:date "2021-01-06T12:29:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The bronchial circulation and other collateral vessels (eg, the intercostal, internal mammary, and inferior phrenic arteries) respond to chronic pulmonary ischemia and decreased pulmonary blood flow through hypertrophy or enlargement in an effort to maintain blood flow to the affected lung and participate in gas exchange through systemic-pulmonary arterial anastomoses that develop beyond the pulmonary artery obstruction." ; rdfs:label "Bronchial artery hypertrophy" ; rdfs:subClassOf obo:HP_0033388 . obo:HP_0033392 obo:IAO_0000115 "Inflammatory cell infiltration surrounding precapillary pulmonary arteries (arterioles; 20-70 micrometer)." ; dc:date "2021-01-06T12:33:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Perivascular inflammation of arterioles in the pulmonary circulation", "Perivascular inflammation of pre-capillary pulmonary arteries" ; a owl:Class ; rdfs:label "Perivascular pre-capillary pulmonary artery inflammation" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0033393 obo:IAO_0000115 "Irregular or changing caliber (diameter) along the tail of the sperm." ; dc:date "2021-01-06T12:41:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sperm flagella with irregular caliber", "Sperm flagella with irregular calibre" ; a owl:Class ; rdfs:label "Irregularly shaped sperm tail" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0033394 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase II." ; dc:date "2021-01-06T12:53:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-carbonic anhydrase II antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033395 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against lactoferrin." ; dc:date "2021-01-06T12:57:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Antilactoferrin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033396 obo:IAO_0000115 "Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina." ; dc:date "2021-01-09T14:19:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Extracapillary fibrin can be associated with glomerular basement membrane (GBM) disruption. In this context, the word aextracapillary refers to abnormalities seen in Bowman's space outside of the GBM." ; rdfs:label "Glomerular extracapillary fibrin" ; rdfs:subClassOf obo:HP_0033312 . obo:HP_0033397 obo:IAO_0000115 "The presence of eosinophilic Periodic Acid Schiff (PAS)-positive cell free, protein-derived material occupying Bowman's space." ; dc:date "2021-01-09T14:24:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bowman-space proteinaceous debris" ; rdfs:subClassOf obo:HP_0033312 . obo:HP_0033398 obo:IAO_0000115 "Deposits of hyalinized collagen fibres in the parietal pleura (preferentially pleura adjacent to ribs, particularly the sixth through ninth ribs)." ; dc:date "2021-01-09T14:32:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pleural plaques are indicative of asbestos exposure. Grossly, the pleural plaque is characterized by hyalinized discrete elevated gray-white or pearly areas involving the parietal pleura. Despite varying sizes and shapes, the pattern of the plaques is repetitive. There is a flat or slightly uneven surface, with steep edges rising abruptly from the surrounding normal pleura, and here and there rounded mounds, with somewhat overhanging edges. The thick pleural plaques are typical in appearance, and the classic comparison is to frosting or sugar icing (Zuckerguss), as is seen on serous membranes." ; rdfs:label "Pleural plaque" ; rdfs:subClassOf obo:HP_0002103 . obo:HP_0033399 obo:IAO_0000115 "Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks." ; dc:date "2021-01-09T14:45:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In most patients with fever lasting 1 to 2 weeks, the etiology will be found or the fever will disappear. If fever persists beyond this point, a patient is said to have a said to have fever of undetermined origin. The distinction between 'fever of unknown origin' (FUO) and 'Persistent fever' is that FUO refers to a febrile disease whose cause is yet unknown, and persistent fever is a clinical manifestation of an FUO or of a disease of known etiology that is characterized by fever that last longer than 2-3 weeks." ; rdfs:label "Persistent fever" ; rdfs:subClassOf obo:HP_0001945 . obo:HP_0033400 obo:IAO_0000115 "A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction." ; dc:date "2021-01-09T14:55:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acute abdominal pain" ; a owl:Class ; rdfs:label "Acute abdomen" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0033401 obo:IAO_0000115 "Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion." ; dc:date "2021-01-09T15:02:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tissue ischemia" ; rdfs:subClassOf obo:HP_0025323 . obo:HP_0033402 obo:IAO_0000115 "Restriction of arterial blood supply to a digit (finger or toe) associated with insufficient oxygenation to support the metabolic requirements of the digit. Clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis." ; dc:date "2021-01-09T15:17:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Digital ischemia" ; rdfs:subClassOf obo:HP_0033401 . obo:HP_0033403 obo:IAO_0000115 "Restriction of arterial blood supply to a testis associated with insufficient oxygenation to support the metabolic requirements of the tissue. Clinical manifestations may include pain and swelling of the affected testis." ; dc:date "2021-01-09T15:21:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Testicular ischemia" ; rdfs:subClassOf obo:HP_0033401 . obo:HP_0033404 obo:IAO_0000115 "Restriction of arterial blood supply to the intestine associated with insufficient oxygenation to support the metabolic requirements of the tissue. Acute intestinal ischemia can involve the small or large intestine, and usually presents with sudden severe non-specific abdominal pain." ; dc:date "2021-01-09T15:23:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intestinal ischemia" ; rdfs:subClassOf obo:HP_0033401 . obo:HP_0033405 obo:IAO_0000115 "Any deviation from the normal concentration of an organic amino compound, defined as a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." ; dc:date "2021-01-09T15:46:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating organic amino compound concentration" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0033406 obo:IAO_0000115 "An increased concentration of o-phosphoethanolamine in the blood circulation." ; dc:date "2021-01-09T15:47:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating o-phosphoethanolamine concentration" ; rdfs:subClassOf obo:HP_0033405 . obo:HP_0033407 obo:IAO_0000115 "Elevated amount of acetoacetic acid in the urine." ; dc:date "2021-01-09T15:59:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine acetoacetic acid level" ; rdfs:subClassOf obo:HP_0002919 . obo:HP_0033408 obo:IAO_0000115 "An increased level of acetoacetic acid in the blood circulation. Acetoacetic acid is one of the predominant ketone bodies." ; dc:date "2021-01-09T16:10:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating acetoacetic acid concentration" ; rdfs:subClassOf obo:HP_0410175 . obo:HP_0033409 obo:IAO_0000115 "An increased amount of 2-hydroxybutyric acid in the urine." ; dc:date "2021-01-09T16:16:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary 2-hydroxybutyric acid" ; rdfs:subClassOf obo:HP_0033303 . obo:HP_0033410 obo:IAO_0000115 "An increased blood concentration of cartilage oligomeric matrix protein (COMP)." ; dc:date "2021-01-09T16:18:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cartilage oligomeric matrix protein (sCOMP) is physiologically located in the extracellular matrix (ECM) of cartilage tissue. It is assumed that sCOMP changes reflect the extrusion of COMP fragments of loaded cartilage tissue." ; rdfs:label "Elevated circulating cartilage oligomeric matrix protein concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033411 obo:IAO_0000115 "Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the lower extremities." ; dc:date "2021-01-09T16:29:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Akinesia of the lower extremities" ; rdfs:label "Lower extremity akinesia" ; rdfs:subClassOf obo:HP_0002304 . obo:HP_0033412 obo:IAO_0000115 "Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the upper extremities." ; dc:date "2021-01-09T16:29:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Akinesia of the upper extremities" ; a owl:Class ; rdfs:label "Upper extremity akinesia" ; rdfs:subClassOf obo:HP_0002304 . obo:HP_0033413 obo:IAO_0000115 "Abnormally diminished movement of the upper extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency." ; dc:date "2021-01-09T16:33:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypokinesia of the upper extremities" ; a owl:Class ; rdfs:label "Upper extremity hypokinesia" ; rdfs:subClassOf obo:HP_0002375 . obo:HP_0033414 obo:IAO_0000115 "Abnormally diminished movement of the lower extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency." ; dc:date "2021-01-09T16:33:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypokinesia of the lower extremities" ; a owl:Class ; rdfs:label "Lower extremity hypokinesia" ; rdfs:subClassOf obo:HP_0002375 . obo:HP_0033415 obo:IAO_0000115 "The accumulation of pericardial fluid with subsequent compression of all cardiac chambers which prevents cardiac filling." ; dc:date "2021-01-09T16:39:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The diagnosis of cardiac tamponade is a clinical diagnosis that requires prompt recognition and treatment to prevent cardiovascular collapse and cardiac arrest." ; rdfs:label "Cardiac tamponade" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0033416 obo:IAO_0000115 "Reduced ability to bring the leg toward the midline of the body." ; dc:date "2021-01-09T16:43:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hip adductor weakness" ; rdfs:subClassOf obo:HP_0003749 . obo:HP_0033417 obo:IAO_0000115 "An increased concentration in the blood circulation of a hydroxybutyric acid, that is, of a compound comprising a butyric acid core carrying at least one hydroxy substituent." ; dc:date "2021-01-09T17:19:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating hydroxybutyric acid concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0033418 obo:IAO_0000115 "Elevation of the 2-hydroxybutyric acid concentration in the blood above the normal range." ; dc:date "2021-01-09T17:22:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating 2-hydroxybutyric acid concentration" ; rdfs:subClassOf obo:HP_0033417 . obo:HP_0033419 obo:IAO_0000115 "Elevation of the 3-hydroxybutyric acid concentration in the blood above the normal range." ; dc:date "2021-01-09T17:23:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating 3-hydroxybutyric acid concentration" ; rdfs:subClassOf obo:HP_0033417 . obo:HP_0033420 obo:IAO_0000115 "Focal proliferation of pulmonary artery endothelial cells, leading to the formation of complex capillary-like channels." ; dc:date "2021-01-09T17:27:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary arterial plexiform lesion" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0033421 obo:IAO_0000115 "Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10%." ; dc:date "2021-01-09T17:29:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary artery intimal thickening" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0033422 obo:IAO_0000115 "Increased amount of collagen, proteoglycans, and other extracellular matrix proteins resulting in scarring and thickening in the adventia of the pulmonary arterial tree." ; dc:date "2021-01-09T17:30:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary artery adventitial fibrosis" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0033423 obo:IAO_0000115 "A form of pulmonary arterial hypertension in which there is a reduction of mean pulmonary artery pressure (mPAP) at leasy 10 mmHg to reach an absolute value of mPAP not more than 40 mmHg with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm." ; dc:date "2021-01-09T17:33:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary arterial hypertension with positive acute response to NO challenge" ; rdfs:subClassOf obo:HP_0002092 . obo:HP_0033424 obo:IAO_0000115 "A form of pulmonary arterial hypertension with lack of adequate hemodynamic response to NO challenge (adequate response is defined as a reduction of mean pulmonary artery pressure (mPAP) of at least 10 mmHg to reach an absolute value of mPAP 40 mmHg or less with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm)." ; dc:date "2021-01-09T17:34:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary arterial hypertension with lack of acute response to NO challenge" ; rdfs:subClassOf obo:HP_0002092 . obo:HP_0033425 obo:IAO_0000115 "Erythema (redness of the skin caused by hyperemia in superficial capillaries) in the region surrounding a fingernail or toe nail." ; dc:date "2021-01-09T17:39:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periungual erythema" ; rdfs:subClassOf obo:HP_0100803 . obo:HP_0033426 obo:IAO_0000115 "Venous air embolism is a consequence of air being introduced into the venous circulation, and subsequently to the right heart, and pulmonary circulation. When small amounts of air reach pulmonary circulation they can be removed by gas diffusion across the arteriolar wall into the alveoli, amounts of gas exceeding 50 ml can cause pulmonary outflow tract obstruction with or without concomitant arterial embolisation." ; dc:date "2021-01-09T17:42:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Venous air embolism" ; a owl:Class ; rdfs:label "Pulmonary air embolism" ; rdfs:subClassOf obo:HP_0002204 . obo:HP_0033427 obo:IAO_0000115 "Focal accumulation of dilated pulmonary capillaries." ; dc:date "2021-01-09T17:45:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary capillary angioectasia" ; rdfs:subClassOf obo:HP_0004930 . obo:HP_0033428 obo:IAO_0000115 "Dysregulation of the innate immune system characterized by systemic pathobiology, i.e., with symptoms that can affect the entire body." ; dc:date "2021-01-09T17:48:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The main cell types of the innate immune system are monocytes, macrophages, and neutrophils and organ damage is mediated by neutrophils and macrophages." ; rdfs:label "Systemic autoinflammation" ; rdfs:subClassOf obo:HP_0012649 . obo:HP_0033429 obo:IAO_0000115 "Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain." ; dc:date "2021-01-09T17:51:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neuroinflammation" ; rdfs:subClassOf obo:HP_0012649 . obo:HP_0033430 obo:IAO_0000115 "Inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused by disorders that are not infections or by drugs or vaccines." ; dc:date "2021-01-09T17:52:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Non-infectious meningitis" ; rdfs:subClassOf obo:HP_0033429 . obo:HP_0033431 obo:IAO_0000115 "A form of cytomegalovirus infection characterized by infection and inflammation of the colon." ; dc:date "2021-01-09T17:55:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CMV colitis" ; a owl:Class ; rdfs:comment "Patients with CMV colitis present with non-specific symptoms, including diarrhea, abdominal pain, fever, rectal bleeding, and weight loss. Hematochezia and diarrhea are the most frequently observed symptoms in these patients. Cytomegalovirus colitis occurs most commonly in immunocompromised hosts, including acquired immunodeficiency syndrome (AIDS), organ transplantation, hematological malignancy, cancer therapy, and corticosteroid therapy." ; rdfs:label "Cytomegalovirus colitis" ; rdfs:subClassOf obo:HP_0031692, obo:HP_0033432 . obo:HP_0033432 dc:date "2021-01-09T17:57:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An infection that is caused by a virus that would generally not be able to cause an infection in a host with a normal immune system. Such viruses take advantage of the opportunity, so to speak, that is provided by a weakened immune system." ; rdfs:label "Opportunistic viral infection" ; rdfs:subClassOf obo:HP_0031690 . obo:HP_0033433 obo:IAO_0000115 "An erosion of the mucous membrane in the region connecting the ileum and cecum." ; dc:date "2021-01-09T18:11:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ileo-cecal ulcer" ; a owl:Class ; rdfs:label "Ileocecal ulcer" ; rdfs:subClassOf obo:HP_0001549, obo:HP_0034274 . obo:HP_0033434 obo:IAO_0000115 "A full-thickness defect of the nasal septum." ; dc:date "2021-01-09T18:14:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Nasal-septum perforation", "Perforation of the nasal septum" ; a owl:Class ; rdfs:label "Nasal septum perforation" ; rdfs:subClassOf obo:HP_0000419 . obo:HP_0033435 obo:IAO_0000115 "A deviation from the normal concentration of a keto acid in the blood circulation. Keto acids or ketoacids are organic compounds that contain a carboxylic acid group and a ketone group." ; dc:date "2021-01-09T18:24:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating keto acid concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0033436 obo:IAO_0000115 "The concentration of 3-methyl-2-oxovaleric acidin the blood circulation is above the upper limit of normal." ; dc:date "2021-01-09T18:25:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating 3-methyl-2-oxovaleric acid concentration" ; rdfs:subClassOf obo:HP_0033435 . obo:HP_0033437 obo:IAO_0000115 "The concentration of 4-methyl-2-oxopentanoic acid in the blood circulation is above the upper limit of normal." ; dc:date "2021-01-09T18:28:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating alpha-ketoisocaproic acid concentration" ; a owl:Class ; rdfs:label "Elevated circulating 4-methyl-2-oxopentanoic acid concentration" ; rdfs:subClassOf obo:HP_0033435 . obo:HP_0033438 obo:IAO_0000115 "An increased blood concentration of myoglobin." ; dc:date "2021-01-09T18:30:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating myoglobin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033439 obo:IAO_0000115 "Increased concentration of decenoylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:40:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-decenoylcarnitine concentration", "Elevated plasma decenoylcarnitine, C10:1" ; a owl:Class ; rdfs:label "Elevated circulating decenoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033440 obo:IAO_0000115 "Increased concentration of octenoylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:42:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-octenoylcarnitine concentration", "Elevated plasma octenoylcarnitine, C8:1" ; a owl:Class ; rdfs:label "Elevated circulating octenoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033441 obo:IAO_0000115 "Increased concentration of hexanoylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:44:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-hexanoylcarnitine concentration", "Elevated plasma hexanoylcarnitine, C6:0" ; a owl:Class ; rdfs:label "Elevated circulating hexanoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033442 obo:IAO_0000115 "Increased concentration of glutarylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:45:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-glutarylcarnitine concentration", "Elevated plasma glutarylcarnitine, C5-DC" ; a owl:Class ; rdfs:label "Elevated circulating glutarylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033443 obo:IAO_0000115 "Increased concentration of propionylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:50:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating propionylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033444 obo:IAO_0000115 "Increased concentration of dodecanoylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:51:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-dodecanoylcarnitine concentration", "Elevated plasma dodecanoylcarnitine, C12:0" ; a owl:Class ; rdfs:label "Elevated circulating dodecanoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033445 obo:IAO_0000115 "An abnormally reduced concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine." ; dc:date "2021-01-09T18:53:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating acylcarnitine concentration" ; rdfs:subClassOf obo:HP_0012071 . obo:HP_0033446 obo:IAO_0000115 "Increased concentration of O-butyrylcarnitine in the blood circulation." ; dc:date "2021-01-09T18:58:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-butyrylcarnitine concentration" ; a owl:Class ; rdfs:label "Elevated circulating butyrylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033447 obo:IAO_0000115 "Increased concentration of O-isovalerylcarnitine in the blood circulation." ; dc:date "2021-01-09T19:03:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating O-isovalerylcarnitine concentration" ; a owl:Class ; rdfs:label "Elevated circulating isovalerylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033448 obo:IAO_0000115 "Elevation of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children." ; dc:date "2021-01-09T20:30:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased mid-arm muscle circumference" ; rdfs:subClassOf obo:HP_0001457 . obo:HP_0033449 obo:IAO_0000115 "Reduction of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children." ; dc:date "2021-01-09T20:38:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased mid-arm muscle circumference" ; rdfs:subClassOf obo:HP_0001457 . obo:HP_0033450 obo:IAO_0000115 "Any deviation from normal concentration of albumin in the blood circulation." ; dc:date "2021-01-09T20:43:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Prealbumin, a hepatic protein, is a marker for protein malnutrition." ; rdfs:label "Abnormal circulating prealbumin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033451 obo:IAO_0000115 "An elevation above the normal concentration of prealbumin in the blood circulation." ; dc:date "2021-01-09T20:45:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating prealbumin concentration" ; rdfs:subClassOf obo:HP_0033450 . obo:HP_0033452 obo:IAO_0000115 "A reduction from the normal concentration of prealbumin in the blood circulation." ; dc:date "2021-01-09T20:45:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating prealbumin concentration" ; rdfs:subClassOf obo:HP_0033450 . obo:HP_0033453 obo:IAO_0000115 "Reduced abilty to move the head back towards the ceiling so that one is looking upwards." ; dc:date "2021-01-09T21:40:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Limited neck extension" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0033454 obo:IAO_0000115 "Feeding problem necessitating food and nutrient delivery via a tube." ; dc:date "2021-01-09T21:48:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tube feeding" ; rdfs:subClassOf obo:HP_0011968 . obo:HP_0033455 obo:IAO_0100001 "HP:0003215" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Elevated urinary dicarboxylic acid level" ; owl:deprecated true . obo:HP_0033456 obo:IAO_0000115 "Increased amount of a keta acid in the urine." ; dc:date "2021-01-09T22:05:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A keta acid is a compound whose molecule contains both a carboxyl group (-COOH) and a ketone group (-CO-)." ; rdfs:label "Elevated urine keto acid level" ; rdfs:subClassOf obo:HP_0033303 . obo:HP_0033457 obo:IAO_0000115 "Increased amount of 3-methyl-2-oxovaleric acid in the urine." ; dc:date "2021-01-09T22:07:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine 3-methyl-2-oxovaleric acid level" ; rdfs:subClassOf obo:HP_0033456 . obo:HP_0033458 obo:IAO_0000115 "Increased amount of 4-methyl-2-oxopentanoic acid in the urine." ; dc:date "2021-01-09T22:08:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urine alpha-ketoisocaproic acid level" ; a owl:Class ; rdfs:label "Elevated urine 4-methyl-2-oxopentanoic acid level" ; rdfs:subClassOf obo:HP_0033456 . obo:HP_0033459 obo:IAO_0000115 "Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein)." ; dc:date "2021-01-09T22:14:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased apolipoprotein level" ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein concentration" ; rdfs:subClassOf obo:HP_0025201 . obo:HP_0033460 obo:IAO_0000115 "Elevated concentration in the blood circulation of a lipid-transport protein (apoliprotein)." ; dc:date "2021-01-09T22:18:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating apolipoprotein circulation" ; rdfs:subClassOf obo:HP_0025201 . obo:HP_0033461 obo:IAO_0000115 "Increased concentration of 3-hydroxylinoleylcarnitine in the blood circulation." ; dc:date "2021-01-09T22:23:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated plasma 3-OH-Linoleylcarnitine, C18:1-OH" ; a owl:Class ; rdfs:label "Elevated circulating 3-hydroxylinoleylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033462 obo:IAO_0000115 "Increased concentration of oleylcarnitine in the blood circulation." ; dc:date "2021-01-09T22:27:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated plasma oleylcarnitine, C18:1" ; a owl:Class ; rdfs:label "Elevated circulating oleylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033463 obo:IAO_0100001 "HP:0031544" ; dc:date "2021-01-09T22:30:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Elevated circulating palmitoleylcarnitine concentration" ; owl:deprecated true . obo:HP_0033464 obo:IAO_0000115 "Increased concentration of 3-hydroxypalmitoleylcarnitine in the blood circulation." ; dc:date "2021-01-09T22:32:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating 3-OH-palmitoleylcarnitine concentration", "Elevated plasma 3-OH-Palmitoleylcarnitine, C16:1-OH" ; a owl:Class ; rdfs:label "Elevated circulating 3-hydroxypalmitoleylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033465 obo:IAO_0000115 "Elevated circulating tetradecanoyl concentration." ; dc:date "2021-01-09T22:34:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating C14 carnitine concentration", "Elevated circulating myristoylcarnitine concentration" ; a owl:Class ; rdfs:label "Elevated circulating tetradecanoylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033466 obo:IAO_0000115 "Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand." ; dc:date "2021-01-09T22:40:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Weak grip" ; rdfs:subClassOf obo:HP_0030237 . obo:HP_0033467 obo:IAO_0000115 "A normal APGAR score can be coded as 'not Low 10-minute APGAR score'." ; dc:date "2021-01-09T22:45:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Low 10-minute APGAR score" ; rdfs:subClassOf obo:HP_0030917 . obo:HP_0033468 dc:date "2021-01-09T22:45:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 0" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033469 dc:date "2021-01-09T22:45:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 1" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033470 dc:date "2021-01-09T22:45:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 2" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033471 dc:date "2021-01-09T22:45:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 3" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033472 dc:date "2021-01-09T22:45:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 4" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033473 dc:date "2021-01-09T22:45:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 5" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033474 dc:date "2021-01-09T22:45:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "10-minute APGAR score of 6" ; rdfs:subClassOf obo:HP_0033467 . obo:HP_0033475 obo:IAO_0000115 "Decreased ability to move the arm away from the midline of the body." ; dc:date "2021-01-09T22:47:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Limited shoulder abduction" ; rdfs:subClassOf obo:HP_0006467 . obo:HP_0033476 obo:IAO_0000115 "The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution." ; dc:date "2021-01-09T22:51:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This is a group of autoantibodies against autoantigens that can be extracted from the cell nucleus with saline. The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70)." ; rdfs:label "Extractable nuclear antigen positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0033477 obo:IAO_0000115 "A deviation from the normal concentration of lipoprotein lipase in the blood circulation." ; dc:date "2021-01-09T22:55:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lipoprotein lipase (LPL) is an extracellular enzyme on the vascular endothelial surface that degrades circulating triglycerides in the bloodstream. These triglycerides are embedded in very low-density lipoproteins (VLDL) and in chylomicrons that travel through the bloodstream." ; rdfs:label "Abnormal circulating lipoprotein lipase concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0033478 obo:IAO_0000115 "Increased concentration of lipoprotein lipase in the blood circulation." ; dc:date "2021-01-09T22:56:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated lipoprotein lipase level" ; a owl:Class ; rdfs:label "Increased circulating lipoprotein lipase concentration" ; rdfs:subClassOf obo:HP_0033477 . obo:HP_0033479 dc:date "2021-01-09T23:02:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating bilirubin concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0033480 obo:IAO_0000115 "Concentration of bilirubin in the blood circulation below the lower limit of normal." ; dc:date "2021-01-09T23:03:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypobilirubinemia" ; rdfs:subClassOf obo:HP_0033479 . obo:HP_0033481 obo:IAO_0000115 "Reduced range of motion resulting in decreased ability to move the ear toward the top of the shoulder." ; dc:date "2021-01-09T23:05:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Limited lateral neck flexion" ; rdfs:subClassOf obo:HP_0005986 . obo:HP_0033482 obo:IAO_0000115 "A reduced ability to flex the shoulder. Shoulder flexion is the motion that moves the arms from a resting position by the side of the body to a position above the head." ; dc:date "2021-01-09T23:28:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Limited shoulder flexion" ; rdfs:subClassOf obo:HP_0006467 . obo:HP_0033483 obo:IAO_0000115 "Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM." ; dc:date "2021-01-10T12:12:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 3d of PMID:32393263 and Figures 1 and 2 of PMID:33276871 for examples." ; rdfs:label "Podocyte infolding" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033484 obo:IAO_0000115 "Increased concentration of linoleylcarnitine in the blood circulation." ; dc:date "2021-01-10T12:30:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated plasma linoleylcarnitine, C18:2" ; a owl:Class ; rdfs:label "Elevated circulating linoleylcarnitine concentration" ; rdfs:subClassOf obo:HP_0045045 . obo:HP_0033485 obo:IAO_0000115 "A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver." ; dc:date "2021-01-10T12:39:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Disruption of the glomerular basement membrane", "Glomerular basement membrane rupture" ; a owl:Class ; rdfs:comment "Disruption of the glomerular basement membrane (GBM) may occur in settings of inflammation (ANCA/antiGBM antibodies) or could be seen due to structural weakness of the GBM (Collagen IV disorders). This feature can be associated with extracapillary fibrin. The definition of this term intends to exclude glomeruli at the edge of the core where rupture could be iatrogenic or mechanical." ; rdfs:label "Glomerular basement membrane disruption" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033486 obo:IAO_0000115 "Anomalous appearance or structure of the surface of the glomerular basement membrane." ; dc:date "2021-01-10T12:45:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal glomerular basement membrane texture" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033487 obo:IAO_0000115 "Punctate electron-dense material typically in a band-like distribution along the lamina rara interna and within tubular basement membranes within the subendothelial aspect of the glomerular basement membrane." ; dc:date "2021-01-10T12:47:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glomerular basement membranes with powdery deposit" ; a owl:Class ; rdfs:label "Glomerular basement membranes powdery deposit" ; rdfs:subClassOf obo:HP_0033486 . obo:HP_0033488 obo:IAO_0000115 "Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries." ; dc:date "2021-01-10T12:54:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glomerular endocapillary hypercellularity consisting of leukocytes" ; a owl:Class ; rdfs:comment "The optimal demonstration of leukocytes may require immunohistochemistry." ; rdfs:label "Glomerular endocapillary leukocyte hypercellularity" ; rdfs:subClassOf obo:HP_0025363 . obo:HP_0033489 obo:IAO_0000115 "Increased number of neutrophils internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries." ; dc:date "2021-01-10T12:57:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular endocapillary neutrophil hypercellularity" ; rdfs:subClassOf obo:HP_0033488 . obo:HP_0033490 obo:IAO_0000115 "Presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in the glomerulus often occupying the endocapillary space." ; dc:date "2021-01-10T12:59:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular endocapillary foam-cell hypercellularity" ; rdfs:subClassOf obo:HP_0033488 . obo:HP_0033491 obo:IAO_0000115 "A generalized global (over 80%) increase of mesangial matrix that is present throughout the mesangial stalk (with or without associated mesangial hypercellularity)." ; dc:date "2021-01-10T13:02:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Glomerular changes can be focal (only in some glomeruli) or diffuse (in all or almost all the glomeruli), and segmental (only a part of the glomerulus) or global (the entire glomerulus)." ; rdfs:label "Global mesangial sclerosis" ; rdfs:subClassOf obo:HP_0033232 . obo:HP_0033492 obo:IAO_0000115 "Reorganization of podocyte cytoskeletal proteins at the glomerular basement membrane (GBM) aspect of the cell, with associated cytoplasmic electron density at the GBM aspect of the podocyte." ; dc:date "2021-01-10T13:12:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Podocyte cytoskeletal condensation" ; rdfs:subClassOf obo:HP_0031265 . obo:HP_0033493 obo:IAO_0000115 "Increased mesangial extracellular material with interspace width of over 2 mesangial cell nuclei, in one or more peripheral mesangial areas." ; dc:date "2021-01-10T13:15:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased glomerular mesangial matrix" ; a owl:Class ; rdfs:label "Mesangial matrix expansion" ; rdfs:subClassOf obo:HP_0033232 . obo:HP_0033494 obo:IAO_0000115 "Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains." ; dc:date "2021-01-10T13:18:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 3 of PMID:25852856." ; rdfs:label "Glomerular basement membrane amyloid spicule" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033495 obo:IAO_0000115 "Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule." ; dc:date "2021-01-10T13:21:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Glomerular changes can be focal (only in some glomeruli) or diffuse (in all or almost all the glomeruli), and segmental (only a part of the glomerulus) or global (the entire glomerulus)." ; rdfs:label "Segmental glomerulosclerosis" ; rdfs:subClassOf obo:HP_0000096 . obo:HP_0033496 obo:IAO_0000115 "Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration is present at the vascular pole, involving less than 50% of the tuft. It can be accompanied by other descriptors such as hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman's capsule." ; dc:date "2021-01-10T13:24:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Segmental glomerulosclerosis, perihilar pattern" ; a owl:Class ; rdfs:label "Perihilar segmental glomerulosclerosis" ; rdfs:subClassOf obo:HP_0033495 . obo:HP_0033497 obo:IAO_0000115 "Segmental solidification of the glomerular tuft characterized by an adhesion at the tip of the glomerular tuft abutting the proximal tubular taek-off can be accompanied by increased extracellular matrix, causing glomerular capillary obliteration at the glomerular tip. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed." ; dc:date "2021-01-10T13:27:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Segmental glomerulosclerosis, tip variant" ; a owl:Class ; rdfs:label "Tip variant segmental glomerulosclerosis" ; rdfs:subClassOf obo:HP_0033495 . obo:HP_0033498 obo:IAO_0000115 "Segmental solidification of the glomerular tuft characterized by increased extracellular matrix, causing glomerular capillary obliteration at neirhter the tubular or vascular poles. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed." ; dc:date "2021-01-10T13:29:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Segmental glomerulosclerosis away from the vascular and tubular poles" ; rdfs:subClassOf obo:HP_0033495 . obo:HP_0033499 obo:IAO_0000115 "Electron-dense deposits in the lamina densa with a ribbon or a sausage structure." ; dc:date "2021-01-10T13:35:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:33329990 for an example." ; rdfs:label "Glomerular basement membrane electron dense deposits" ; rdfs:subClassOf obo:HP_0033282 . obo:HP_0033500 obo:IAO_0000115 "Electron dense deposits in the glomerular basement membrane (GBM) subendothelial space associated with a prominent GBM reflecting an increase in thickness. This feature can be associated with GBM remodeling along the endothelial aspect." ; dc:date "2021-01-10T13:41:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The glomerular filtration barrier consists of two cells (podocytes and endothelial cells) and the glomerular basement membrane (GBM), a specialized extracellular matrix that lies between them." ; rdfs:label "Subendothelial glomerular basement membrane electron dense deposits" ; rdfs:subClassOf obo:HP_0033499 . obo:HP_0033501 obo:IAO_0000115 "Prominent glomerular basement membrane (GBM) reflecting a diffuse and relativly uniform increase in thickness (subjective estimate) with exogenous material deposited between the outer (epithelial) aspect of the GBM and the visceral epithelial cell, with varying degrees of incorporation into the GBM." ; dc:date "2021-01-10T14:16:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subepithelial glomerular basement membrane electron dense deposits" ; rdfs:subClassOf obo:HP_0033499 . obo:HP_0033502 obo:IAO_0000115 "Any deviation from the normal ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine." ; dc:date "2021-01-10T15:09:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Carnitine is a nutrient that is made from the amino acids methionine and lysine. Its primary role is to allow the transport of long-chain fatty acids into the mitochondrial matrix for beta-oxidation and energy production. Carnitine is stored in the skeletal muscle, heart, liver, brain, and kidney and within plasma. Carnitine is also found in the body in several different forms." ; rdfs:label "Abnormal esterified to free carnitine ratio" ; rdfs:subClassOf obo:HP_0012071 . obo:HP_0033503 obo:IAO_0000115 "An increased concentration of fumarate, an intermediate in the citric acid cycle, in the cebrebrospinal fluid." ; dc:date "2021-01-10T14:28:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated CSF fumarate concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0033504 obo:IAO_0000115 "An increased concentration of fumarate, an intermediate in the citric acid cycle, in the blood circulation." ; dc:date "2021-01-10T14:29:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating fumarate concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0033505 obo:IAO_0000115 "Livedo reticularis is characterized by the presence of a bluish purple, mottled or netlike pattern in unbroken circles on the skin. Exposure to cold environments usually intensifies the vascular pattern. Presumably, the condition results from slow or stagnant blood flow, vessel-wall pathology, and decreased oxygen tension." ; dc:date "2021-01-10T14:43:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The distinction to cutis marmorata is that the mottling does not resolve when the skin is warmed, and the discoloration is bluish purple rather than red. The Livedo reticularis lesion is more intense and is persistent." ; rdfs:label "Livedo reticularis" ; rdfs:subClassOf obo:HP_0033832 . obo:HP_0033506 obo:IAO_0000115 "An elevated ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine." ; dc:date "2021-01-10T15:13:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased esterified to free carnitine ratio" ; rdfs:subClassOf obo:HP_0033502 . obo:HP_0033507 obo:IAO_0000115 "A reduced ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine." ; dc:date "2021-01-10T15:13:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased esterified to free carnitine ratio" ; rdfs:subClassOf obo:HP_0033502 . obo:HP_0033508 obo:IAO_0000115 "Inflammation of the meninges related to infection by Epstein-Barr virus." ; dc:date "2021-01-10T17:16:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Epstein-Barr virus meningitis" ; a owl:Class ; rdfs:label "EBV meningitis" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0033509 obo:IAO_0000115 "Inflamation of the brain related to infection by Epstein-Barr virus." ; dc:date "2021-01-10T17:18:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Epstein-Barr virus encephalitis" ; a owl:Class ; rdfs:label "EBV encephalitis" ; rdfs:subClassOf obo:HP_0033993 . obo:HP_0033510 obo:IAO_0000115 "A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin." ; dc:date "2021-01-13T12:03:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cornu cutaneum" ; a owl:Class ; rdfs:label "Cutaneous horn" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0033511 obo:IAO_0000115 "Chronic compulsive drug seeking and continued use despite harmful consequences." ; dc:date "2021-01-13T12:11:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), drug addiction may be characterized by manifestations including: (1) The substance is often taken in larger amounts or over a longer period than was intended; (2) A persistent desire or unsuccessful effort to cut down or control use of the substance; (3) substantial time and effort spent to obtain the substance; (4) Craving; (5) Recurrent use of the substance resulting in a failure to fulfill major obligations; (6) Continued use of the substance despite interpersonal problems caused by substance use; (7) Important social, occupational, or recreational activities are given up (8) Recurrent use of the substance even in situations in which it is physically hazardous; (9) Use of the substance despite awareness of its problematic consequences; (10) Tolerance; and (11) Withdrawal symptoms." ; rdfs:label "Drug addiction" ; rdfs:subClassOf obo:HP_0030858 . obo:HP_0033512 obo:IAO_0000115 "Addiction to a stimulant drug, defined as a drug that typically increases alertness, attention and energy while also elevating blood pressure, heart rate and breathing." ; dc:date "2021-01-13T12:19:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Stimulant dependence" ; a owl:Class ; rdfs:label "Stimulant addiction" ; rdfs:subClassOf obo:HP_0033511 . obo:HP_0033513 obo:IAO_0000115 "Addiction to cocaine." ; dc:date "2021-01-13T12:21:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cocaine dependence" ; a owl:Class ; rdfs:label "Cocaine addiction" ; rdfs:subClassOf obo:HP_0033512 . obo:HP_0033514 obo:IAO_0000115 "Addiction to amphetamine or dextroamphetamine." ; dc:date "2021-01-13T12:23:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amphetamine dependence", "Dextroamphetamine addiction", "Dextroamphetamine dependence" ; a owl:Class ; rdfs:label "Amphetamine addiction" ; rdfs:subClassOf obo:HP_0033512 . obo:HP_0033515 obo:IAO_0000115 "Addiction to opioids." ; dc:date "2021-01-13T12:25:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Opioid dependence" ; a owl:Class ; rdfs:label "Opioid addiction" ; rdfs:subClassOf obo:HP_0033511 . obo:HP_0033516 obo:IAO_0000115 "Addiction to a benzodiazepine." ; dc:date "2021-01-13T12:30:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Benzodiazepine dependence" ; a owl:Class ; rdfs:label "Benzodiazepine addiction" ; rdfs:subClassOf obo:HP_0033511 . obo:HP_0033517 obo:IAO_0000115 "Addiction to heroin." ; dc:date "2021-01-13T12:32:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heroin dependence" ; a owl:Class ; rdfs:label "Heroin addiction" ; rdfs:subClassOf obo:HP_0033515 . obo:HP_0033518 obo:IAO_0000115 "Addiction to methylphenidate." ; dc:date "2021-01-13T12:33:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Methylphenidate dependence" ; a owl:Class ; rdfs:comment "Methylphenidate is used to treat attention deficit hyperactivity disorder." ; rdfs:label "Methylphenidate addiction" ; rdfs:subClassOf obo:HP_0033512 . obo:HP_0033519 obo:IAO_0000115 "Addiction to methamphetamine." ; dc:date "2021-01-13T12:36:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Methamphetamine dependence" ; a owl:Class ; rdfs:label "Methamphetamine addiction" ; rdfs:subClassOf obo:HP_0033512 . obo:HP_0033520 obo:IAO_0000115 "Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation." ; dc:date "2021-01-13T13:59:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Paradoxical embolism occurs most commonly through an intracardiac defect at the atrial level, but can also be due to another type of right-to-left-shunt, as for example in pulmonary arteriovenous malformations. Paradoxical embolism may lead to serious complications as ischemic stroke." ; rdfs:label "Paradoxical embolism" ; rdfs:subClassOf obo:HP_0001907 . obo:HP_0033521 obo:IAO_0000115 "A lack of humidification of the nasal mucosa." ; dc:date "2021-01-14T12:33:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A dry nose can be associated with multiple causes, for example an underlying disease, medication or age-related changes in nasal physiology and structure." ; rdfs:label "Nasal dryness" ; rdfs:subClassOf obo:HP_0000433 . obo:HP_0033522 obo:IAO_0000115 "A cerebral cavernous malformation (also known as cavernoma, cavernous angioma, cavernous hemangioma) is a collection of structurally abnormal slow-flow capillaries predominantly in the central nervous system. These are multiple mulberry-like distended caverns of dilated thin-walled capillaries without the normal intervening brain parenchymal architecture. Often, individual cavernomas are surrounded by hemosiderin representing remote oozing due to the abnormal capillaries." ; dc:date "2021-01-14T13:02:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cerebral cavernous malformation (CCMs) have been reported to be the second most common vascular malformation of the central nervous system after developmental venous anomalies (DVA). The majority of CCM cases comprises a single lesion with or without associated DVA. These are called sporadic CCMs and are often asymptomatic and nonhereditary. The other type, called hereditary or familial CCM (FCCM), is due to autosomal dominant inherited genetic mutation, associated with multiple lesions. CCM can be found at multiple locations in the central nervous system with supratentorial lesions being more common than the infratentorial lesions." ; rdfs:label "Cerebral cavernous malformation" ; rdfs:subClassOf obo:HP_0001048, obo:HP_0100659 . obo:HP_0033523 obo:IAO_0000115 "A structural anomaly of the part of the sperm flagellum that is distal to the sperm midpiece and mitochondrial sheath and which leads into the end piece." ; dc:date "2021-01-14T13:15:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal sperm principal piece morphology" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0033524 obo:IAO_0000115 "Abnormal structure of the sperm axonemal structure which consists of a ring of nine microtubular doublets and a central pair of microtubules, giving the classical 9+2 microtubular arrangement. The axoneme contains a central pair of microtubules (C1 and C2) that are connected by a bridge-like structure forming the central pair complex (CPC). Each of the nine outer doublets is composed of type A and B microtubules and connected by radial spokes to the CPC." ; dc:date "2021-01-14T13:25:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal sperm axoneme morphology" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0033525 obo:IAO_0000115 "Absense of the central pair of microtubules in the sperm axoneme, thereby forming a 9+0 pattern instead of the normal 9+2 pattern." ; dc:date "2021-01-14T13:30:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent central pair complex (9+0 pattern)" ; a owl:Class ; rdfs:label "Absent sperm axoneme central pair complex" ; rdfs:subClassOf obo:HP_0033524 . obo:HP_0033526 obo:IAO_0000115 "Reduced ability to move the foot up toward the shin." ; dc:date "2021-01-15T12:25:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heel cord tightness", "Tight heel cord" ; a owl:Class ; rdfs:label "Limited ankle dorsiflexion" ; rdfs:subClassOf obo:HP_0010505 . obo:HP_0033527 obo:IAO_0000115 "A reduced amount of testosterone relative in androstenedione in the blood circulation following administration of hCG (Human Chorionic Gonadotropin)." ; dc:date "2021-01-15T12:34:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased plasma testosterone-to-androstenedione ratio" ; a owl:Class ; rdfs:comment "Androstenedione is made in the adrenal glands as well as the testes and ovaries. In females, androstenedione is converted to provide around half of all testosterone and almost all estrone. In males, androstenedione is produced by the testes and rapidly converted to testosterone. A low testosterone:androstenedione ratio following hCG stimulation may be a useful method of diagnosing 17beta-hydroxysteroid dehydrogenase-3 (17 betaHSD3) deficiency." ; rdfs:label "Decreased gonadotropin-stimulated testosterone-to-androstenedione ratio" ; rdfs:subClassOf obo:HP_0030347 . obo:HP_0033528 obo:IAO_0000115 "A deviation from normal Cardiac output, which is defined as the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs." ; dc:date "2021-01-15T12:48:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiac output" ; rdfs:subClassOf obo:HP_0011028 . obo:HP_0033529 obo:IAO_0000115 "Any deviation from the normal value of the cardiac index, defined as cardiac output divided by body surface area." ; dc:date "2021-01-15T12:50:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cardiac output (CO) can be further broken down as the product of stroke volume (SV), which is the blood volume ejected by one heartbeat, and heart rate (HR), which is the number of heartbeats per minute. Therefore, the cardiac index can be defined as Cardiac Output / Body Surface Area = (Heart Rate * Stroke Volume) / Body Surface Area." ; rdfs:label "Abnormal cardiac index" ; rdfs:subClassOf obo:HP_0033528 . obo:HP_0033530 obo:IAO_0000115 "An elevated cardiac index, defined as cardiac output divided by body surface area." ; dc:date "2021-01-15T12:53:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased cardiac index" ; rdfs:subClassOf obo:HP_0033529 . obo:HP_0033531 obo:IAO_0000115 "A reduced cardiac index, defined as cardiac output divided by body surface area." ; dc:date "2021-01-15T12:55:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased cardiac index" ; rdfs:subClassOf obo:HP_0033529 . obo:HP_0033532 obo:IAO_0000115 "A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat." ; dc:date "2021-01-15T12:56:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased cardiac output" ; rdfs:subClassOf obo:HP_0033528 . obo:HP_0033533 obo:IAO_0000115 "An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat." ; dc:date "2021-01-15T12:57:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased cardiac output" ; rdfs:subClassOf obo:HP_0033528 . obo:HP_0033534 obo:IAO_0000115 "An increased concentration of brain natriuretic peptide in the blood circulation." ; dc:date "2021-01-15T12:59:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating BNP concentration", "Increased B-type natriuretic peptide", "Increased ventricular natriuretic peptide" ; a owl:Class ; rdfs:comment "BNP is a hormone secreted by ventricular cardiomyocytes in response to stretching caused by increased ventricular blood volume. BNP is synthesised as a prohormone (proBNP) comprising 108 amino acids. After the release into the circulation proBNP is cleaved in equimolar amounts into the biologically active BNP (32 amino acid), and the biologically inactive 76 amino acid N-terminal fragment (NT-proBNP). BNP has a number of physiological effects including natriuresis and diuresis, peripheral vasodilation, inhibition of renin angiotensin aldosterone system (RAAS) and the sympathetic nervous system (SNS)." ; rdfs:label "Increased circulating brain natriuretic peptide concentration" ; rdfs:subClassOf obo:HP_0031138 . obo:HP_0033535 obo:IAO_0000115 "Decreased number of platelet dense granules, a type of platelet organelle." ; dc:date "2021-01-15T13:04:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced platelet dense granules" ; rdfs:subClassOf obo:HP_0012530 . obo:HP_0033536 obo:IAO_0000115 "A reduced number of platelet alpha granules." ; dc:date "2021-01-15T13:05:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced platelet alpha granules" ; rdfs:subClassOf obo:HP_0012528 . obo:HP_0033537 obo:IAO_0000115 "Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging." ; dc:date "2021-01-15T15:29:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mosaic attenuation may result from occlusive vascular disease, obstructive small airways disease, pulmonary edema or pulmonary hemorrhage." ; rdfs:label "Mosaic pulmonary attenuation pattern" ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0033538 obo:IAO_0000115 "Pathological deposition of calcium salts in the aortic annulus, a fibrous ring-like structure found at the insertion point of the basal attachments of the aortic valve leaflets within the left ventricular outflow tract." ; dc:date "2021-01-20T12:07:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic annular calcification" ; a owl:Class ; rdfs:comment "Anatomically, the aortic annulus (AA) is a complex 3-dimensional (3D) crown-shape structure that is part of the fibrous skeleton of the heart. From a surgical stand point, the AA is generally located at the anatomic ventriculoaortic junction onto which a prosthetic valve can be sewn. Conversely, from an imaging perspective, the annulus corresponds to a virtual ring formed by linking the basal attachments of the 3 aortic leaflets." ; rdfs:label "Aortic annulus calcification" ; rdfs:subClassOf obo:HP_0004380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005991 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001512 ] ) ] ] . obo:HP_0033539 obo:IAO_0000115 "A reticular pattern of linear or lineonodular densities in apical portions of both the right and left lungs seen initially on high-resolution computed tomography and in case of progression also on standard chest x-ray." ; dc:date "2021-01-20T12:24:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bilateral apical fibrosis is a characteristic finding in ankylosing spondylitis." ; rdfs:label "Bilateral apical pulmonary fibrosis" ; rdfs:subClassOf obo:HP_0002206 . obo:HP_0033540 obo:IAO_0000115 "Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL." ; dc:date "2021-01-20T14:55:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reversible pulmonary obstruction" ; a owl:Class ; rdfs:label "Reversible airflow obstruction" ; rdfs:subClassOf obo:HP_0006536 . obo:HP_0033541 obo:IAO_0000115 "Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL." ; dc:date "2021-01-20T14:56:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Irreversible pulmonary obstruction" ; a owl:Class ; rdfs:label "Irreversible airflow obstruction" ; rdfs:subClassOf obo:HP_0006536 . obo:HP_0033542 obo:IAO_0000115 "Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density." ; dc:date "2021-01-21T12:32:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peribronchial cuffing", "Peribronchial thickening" ; a owl:Class ; rdfs:label "Bronchial wall thickening" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033543 obo:IAO_0000115 "Nicotine addition can be defined as chronic compulsive nicotine seeking and continued use despite harmful consequences." ; dc:date "2021-01-21T12:43:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Nicotine dependence" ; a owl:Class ; rdfs:label "Nicotine addiction" ; rdfs:subClassOf obo:HP_0033511 . obo:HP_0033544 obo:IAO_0000115 "Extracellular mesangial accumulation of slender proteinaceous fibers." ; dc:date "2021-01-21T13:33:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial fibril deposition" ; rdfs:subClassOf obo:HP_0001966 . obo:HP_0033545 obo:IAO_0000115 "Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material." ; dc:date "2021-01-21T13:36:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial fibrillary deposits" ; rdfs:subClassOf obo:HP_0033544 . obo:HP_0033546 obo:IAO_0000115 "Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins." ; dc:date "2021-01-21T13:38:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial microfibril deposition" ; rdfs:subClassOf obo:HP_0033544 . obo:HP_0033547 obo:IAO_0000115 "Extracellular mesangial aggregates composed of non-branching fibrils, focally parralel over 30 nM in diameter. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination." ; dc:date "2021-01-21T13:40:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial immunotactoid deposits" ; rdfs:subClassOf obo:HP_0033544 . obo:HP_0033548 obo:IAO_0000115 "Extracellular mesangial aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass." ; dc:date "2021-01-21T13:43:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mesangial amyloid deposition" ; rdfs:subClassOf obo:HP_0033544 . obo:HP_0033549 obo:IAO_0000115 "Lobular, round to oval mesangial lesions with an acellular hyaline/matrix core surrounded by compressed mesangial nuclei." ; dc:date "2021-01-21T13:46:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Nodular mesangiosclerosis is a pattern that can be observed together with mesangolysis but may also occur independently and so should be coded separately." ; rdfs:label "Nodular mesangiosclerosis" ; rdfs:subClassOf obo:HP_0033232 . obo:HP_0033550 obo:IAO_0000115 "A granuloma that is associated with necrotic changes. Caseation necrosis is defined as a region in granulomas with eosinophilic, granular and cheese-like cellular debris with necrosis. The word caseous itself means pertaining or related to cheese, and comes from the Latin word caseus, meaning cheese." ; dc:date "2021-01-22T12:12:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Caseating pulmonary granulomatosis" ; a owl:Class ; rdfs:comment "In hematoxylin and eosin stain staining, necrotizing pulmonary granulomatosis is characterized by acellular pink areas of necrosis surrounded by a granulomatous inflammatory process." ; rdfs:label "Necrotizing pulmonary granulomatosis" ; rdfs:subClassOf obo:HP_0030250 . obo:HP_0033551 obo:IAO_0000115 "A granuloma located in the lung that is not associated with necrotic changes." ; dc:date "2021-01-22T12:14:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Non-caseating pulmonary granulomatosis" ; a owl:Class ; rdfs:label "Non-necrotizing pulmonary granulomatosis" ; rdfs:subClassOf obo:HP_0030250 . obo:HP_0033552 obo:IAO_0000115 "Villitis of unknown etiology (synonymous with villitis of unknown aetiology) is a histologic diagnosis and, although it may have a variable distribution, evidence indicates that 3 parenchymal blocks will identify 62% of villitis, reaching an asymptote of 6 and 7 blocks identifying 85% of villitis. Villitis of unknown etiology by definition excludes those cases where an etiology is identified, such as viral or acute infections, and thus is preferred to the term nonspecific chronic villitis. It is usually lymphohistiocytic: although the presence of rare plasma cells does not exclude the diagnosis, thorough evaluation for an infectious etiology, such as cytomegalovirus, is required in a predominantly plasma cell villitis." ; dc:date "2021-01-22T12:38:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic villitis (non-infectious)", "Nonspecific chronic villitis", "Villitis of unknown aetiology", "Villitis of unknown etiology" ; a owl:Class ; rdfs:label "Chronic villitis" ; rdfs:subClassOf obo:HP_0011409 . obo:HP_0033553 obo:IAO_0000115 "Embolization of intravascular thrombus containing microorganisms into the distant tissues via arterial system." ; dc:date "2021-01-22T12:51:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Septic emboli" ; a owl:Class ; rdfs:label "Septic embolism" ; rdfs:subClassOf obo:HP_0001907 . obo:HP_0033554 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against the Mi-2 antigen." ; dc:date "2021-01-23T11:39:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The Mi-2 antigen is a nuclear antigen, component of the Nucleosome Remodelling-Deacetylase (NuRD) complex involved in transcription regulation. Autoantibodies targeting the Mi-2 nuclear antigen are a serologic hallmark of idiopathic inflammatory myopathies, with a diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. They are most strongly associated with dermatomyositis and correlate with HLA-DR7." ; rdfs:label "Anti-Mi2 antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0033555 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against Ro/SSA autoantigens." ; dc:date "2021-01-23T11:41:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ro/SSA antibody positivity" ; a owl:Class ; rdfs:comment "Anti-Ro/SS-A antibodies alone are found in 50-70% of Sjoegren syndrome and 30% of systemic lupus erythematosus (SLE) with cutaneous involvement." ; rdfs:label "Anti-Ro/SS-A antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0033556 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against nucleoporin 62." ; dc:date "2021-01-23T11:50:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-p62 antibody positivity" ; a owl:Class ; rdfs:comment "Anti-nucleoporin 62 antibody is an antibody directed against components of the nuclear membrane and is typically found in primary biliary cirrhosis." ; rdfs:label "Anti-nucleoporin 62 antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0033557 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against proteinase 3. Proteinase 3 (PR3) antigen is a 29-kD serine protease that exists as a protein triplet in human neutrophils" ; dc:date "2021-01-23T12:05:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PR3 antibody positivity" ; a owl:Class ; rdfs:comment "PR3 directed c-ANCA antibodies are present in 80-90% of granulomatosis with polyangiitis, 20-40% of microscopic polyangiitis, 20-40% of pauci-immune crescentic glomerulonephritis and 35% of eosinophilic granulomatosis with polyangiitis." ; rdfs:label "Anti-proteinase 3 antibody positivity" ; rdfs:subClassOf obo:HP_0032230 . obo:HP_0033558 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone antigens." ; dc:date "2021-01-23T12:10:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anti-histone antibodies are found in the serum of up to 75-95% of people with drug-induced lupus and 75% of idiopathic SLE and less frequently in scleroderma, rheumatoid arthritis and undifferentiated connective tissue disease." ; rdfs:label "Anti-histone antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0033559 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against myeloperoxidase." ; dc:date "2021-01-23T12:16:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-MPO antibody positivity" ; a owl:Class ; rdfs:label "Anti-myeloperoxidase antibody positivity" ; rdfs:subClassOf obo:HP_0032229 . obo:HP_0033560 obo:IAO_0000115 "Anti-PM-Scl antibodies target components of RNA-processing exosome complex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100, PM/Scl-75, hRrp4, hRrp42, hRrp46, hCs14, hRrp41, and hRrp40." ; dc:date "2021-01-23T12:21:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PM/Scl antibody positivity" ; a owl:Class ; rdfs:comment "Anti-PM-Scl antibodies are found in up to 50% of polymyositis/systemic sclerosis (PM/SSc) overlap syndrome. Around 80% of individuals with antibodies present in their blood serum will have the disorder. The presence of the antibodies is linked to limited cutaneous involvement of PM/SSc overlap syndrome." ; rdfs:label "Anti-PM-Scl antibody positivity" ; rdfs:subClassOf obo:HP_0003493 . obo:HP_0033561 obo:IAO_0000115 """The presence of autoantibodies in the blood circulation that react against bactericidal/permeability-increasing protein (BPI). BPI is an endotoxin-binding host protein with important antibacterial effects against Gram-negative bacteria, such as Pseudomonas aeruginosa. BPI is a 55 kDalton protein that is most abundant in the azurophilic granules of neutrophils. BPI also acts as a target antigen for antineutrophil cytoplasmic autoantibodies.""" ; dc:date "2021-01-23T12:25:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-BPI antibody positivity" ; a owl:Class ; rdfs:label "Anti-bactericidal/permeability-increasing protein antibody positivity" ; rdfs:subClassOf obo:HP_0032230 . obo:HP_0033562 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against glycoprotein-210." ; dc:date "2021-01-23T12:35:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-gp210 antibody positivity" ; a owl:Class ; rdfs:comment "Anti-glycoprotein-210 antibody is an antibody directed against components of the nuclear membrane and is found in primary biliary cirrhosis." ; rdfs:label "Anti-glycoprotein-210 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033563 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase." ; dc:date "2021-01-23T12:45:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-tTG antibody positivity" ; a owl:Class ; rdfs:label "Anti-tissue transglutaminase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033564 obo:IAO_0000115 "Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus." ; dc:date "2021-01-23T12:54:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Varicose eczema", "Venous eczema" ; a owl:Class ; rdfs:label "Stasis dermatitis" ; rdfs:subClassOf obo:HP_0000964 . obo:HP_0033565 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against epidermal transglutaminase." ; dc:date "2021-01-23T13:00:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-TG3 antibody", "Anti-eTG antibody positivity", "Anti-epidermal transglutaminase (anti-eTG) antibody", "Anti-keratinocyte transglutaminase" ; a owl:Class ; rdfs:label "Anti-epidermal transglutaminase antibody positivity" ; rdfs:subClassOf obo:HP_0033563 . obo:HP_0033566 obo:IAO_0000115 "Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization." ; dc:date "2021-01-24T13:37:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal QRS axis" ; a owl:Class ; rdfs:comment "The normal adult QRS axis is between -30 degrees and +90 degrees, which is directed downward and to the left." ; rdfs:label "Abnormal ventricular axis" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0033567 obo:IAO_0000115 "A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between +90 degrees and 180 degrees, or beyond +100 degrees if the adult range is used." ; dc:date "2021-01-24T13:39:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Electrical right axis deviation", "RAD" ; a owl:Class ; rdfs:label "Right axis deviation" ; rdfs:subClassOf obo:HP_0033566 . obo:HP_0033568 obo:IAO_0000115 "A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between -30 degrees and -90 degrees." ; dc:date "2021-01-24T13:42:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Electrical left axis deviation" ; a owl:Class ; rdfs:label "Left axis deviation" ; rdfs:subClassOf obo:HP_0033566 . obo:HP_0033569 obo:IAO_0000115 "A kind of abnormal ventricular axis in the EKG whereby the QRS axis fall sbetween -90 degrees and 180 degrees. In this case, the ventricular vector is directed upward and to the right." ; dc:date "2021-01-24T13:43:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extreme axis deviation" ; rdfs:subClassOf obo:HP_0033566 . obo:HP_0033570 obo:IAO_0000115 "A kind of abnormal ventricular axis in the EKG whereby the QRS complex is isoelectric or equiphasic in all leads with no dominant QRS deflection." ; dc:date "2021-01-24T13:44:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Indeterminate ventricular axis" ; rdfs:subClassOf obo:HP_0033566 . obo:HP_0033571 obo:IAO_0000115 "The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy." ; dc:date "2021-01-24T13:48:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peripheral lung neovascularity" ; rdfs:subClassOf obo:HP_0004930 . obo:HP_0033572 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone H1." ; dc:date "2021-01-24T13:51:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H1 antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033573 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone H4." ; dc:date "2021-01-24T13:56:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H4 antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033574 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone H3." ; dc:date "2021-01-24T13:56:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H3 antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033575 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone H2A." ; dc:date "2021-01-24T13:57:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H2A antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033576 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against histone H2B." ; dc:date "2021-01-24T13:58:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H2B antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033577 obo:IAO_0000115 "Localized thrombosis in pulmonary arteries frequently found in patients with idiopathic and hereditary pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease." ; dc:date "2021-01-24T14:06:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "In situ pulmonary artery thrombosis" ; rdfs:subClassOf obo:HP_0030966 . obo:HP_0033578 obo:IAO_0000115 "Pre-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary vascular resistance (PVR 3 Wood units or more) accompanied by normal pulmonary artery wedge pressure (PAWP not more than 15 mmHg)." ; dc:date "2021-01-24T14:20:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Precapillary pulmonary hypertension" ; a owl:Class ; rdfs:label "Pre-capillary pulmonary hypertension" ; rdfs:subClassOf obo:HP_0004890 . obo:HP_0033579 obo:IAO_0000115 "Insufficient growth hormone secretion following administration of growth hormone-releasing hormone." ; dc:date "2021-01-24T14:55:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired growth hormone secretory responses after growth hormone-releasing hormone challenge" ; a owl:Class ; rdfs:label "Decreased growth hormone responses to growth hormone-releasing hormone challenge" ; rdfs:subClassOf obo:HP_0000824 . obo:HP_0033580 obo:IAO_0000115 "An abnormal finding in a compound motor action potential measurement in EMG. Nerve conduction studies involve the application of a depolarising square wave electrical pulses to the skin over a peripheral nerve producing: (1) a propagated nerve action potential (NAP) recorded at a distant point over the same nerve: and (2) a compound muscle action potential (CMAP) arising from the activation of muscle fibres in a target muscle supplied by the nerve. In both cases these may be recorded with surface or needle electrodes. The CMAP is a summated voltage response from the individual muscle fibre action potentials. The shortest latency of the CMAP is the time from stimulus artefact to onset of the response and is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV)." ; dc:date "2021-01-24T16:18:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Compound motor action potential abnormality" ; rdfs:subClassOf obo:HP_0040131 . obo:HP_0033581 obo:IAO_0000115 "The absence of any palpable lymph nodes in the presence of symptoms suggesting infection in that drainage area should raise suspicion for immunodeficiency diseases." ; dc:date "2021-01-24T16:35:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent peripheral lymph nodes in presence of infection" ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0033582 obo:IAO_0000115 "Abnormal accumulation of lymphocytes in the interstitium of the lung." ; dc:date "2021-01-27T20:32:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary interstitial lymphocyte infiltration" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0033583 obo:IAO_0000115 "Follicular bronchiolitis is a polyclonal hyperplasia of bronchiolar associated lymphoid tissue characterized by the is characterized by the development of lymphoid follicles with germinal centers in walls of the small airways." ; dc:date "2021-01-27T20:37:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lymphocytic interstitial pneumonia (LIP) and follicular bronchiolitis (FB) are assumed to be pathological immunologic responses to different triggers and are particularly associated with autoimmune and infectious diseases as well as immunodeficiency. LIP can be defined as a dense, predominantly lymphocytic interstitial infiltrate that expands alveolar septa. In contrast, FB can be defined as a pattern of numerous lymphoid follicles associated with bronchioles and the immediate peribronchiolar interstitium. A grading system can be use to assess presence and extent of LIP and FB. Lymphocyte aggregates are defined as the aggregation of 50 or more lymphocytes per high-power field. Tissue was scored as grade 0 in the absence of lymphocyte aggregates, grade 1 with 0 to 1 aggregate/10 mm 2 , grade 2 with greater than 1 aggregate/10 mm 2 , grade 3 with greater than 1 aggregate/10 mm 2 and the presence of focal lymphoid interstitial pneumonia, and grade 4 with greater than 1 aggregate/10 mm 2 and the presence of diffuse LIP." ; rdfs:label "Follicular bronchiolitis" ; rdfs:subClassOf obo:HP_0033582 . obo:HP_0033584 obo:IAO_0000115 "Temporally uniform (all lesions are in the same stage of evolution) pattern of diffuse inflammatory interstitial process, mostly symmetric over the entire lung, involving mainly the alveolar septa." ; dc:date "2021-01-27T20:40:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "NSIP", "Nonspecific interstitial pneumonitis", "Temporally uniform pulmonary inflammation" ; a owl:Class ; rdfs:label "Nonspecific interstitial pneumonia" ; rdfs:subClassOf obo:HP_0006515 . obo:HP_0033585 obo:IAO_0000115 "A type of non-specific interstitial pneumonia in which interstitial thickening is due to uniform dense or loose fibrosis and mild chronic inflammation." ; dc:date "2021-01-27T20:44:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrotic non-specific interstitial pneumonia" ; rdfs:subClassOf obo:HP_0033584 . obo:HP_0033586 obo:IAO_0000115 "A type of non-specific interstitial pneumonia in which interstitial thickening is mainly due to infiltration of inflammatory cells and type II pneumocyte hyperplasia." ; dc:date "2021-01-27T20:46:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cellular non-specific interstitial pneumonia" ; rdfs:subClassOf obo:HP_0033584 . obo:HP_0033587 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the vulvar region." ; dc:date "2021-01-27T21:11:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vulvar abscess" ; rdfs:subClassOf obo:HP_0025615 . obo:HP_0033588 obo:IAO_0000115 "Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline." ; dc:date "2021-01-27T21:15:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Labial agglutination", "Synechia vulvae" ; a owl:Class ; rdfs:label "Labial adhesion" ; rdfs:subClassOf obo:HP_0012881 . obo:HP_0033589 obo:IAO_0000115 "Passage of excessive amounts of gas and the feeling of abdominal fullness and bloating." ; dc:date "2021-01-27T21:29:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Flatulence" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0033590 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the groin (inguinal region)." ; dc:date "2021-01-28T02:06:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Groin abscess" ; a owl:Class ; rdfs:label "Inguinal abscess" ; rdfs:subClassOf obo:HP_0025615 . obo:HP_0033591 obo:IAO_0000115 "Large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system." ; dc:date "2021-01-28T02:08:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Staghorn renal stone" ; a owl:Class ; rdfs:label "Staghorn calculus" ; rdfs:subClassOf obo:HP_0000787 . obo:HP_0033592 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against the H3-H4 histone dimer." ; dc:date "2021-01-28T02:13:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H3-H4 antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033593 obo:IAO_0000115 "The presence of autoantibodies in the blood circulation that react against the H2A-H2B histone dimer." ; dc:date "2021-01-28T02:15:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-H2A-H2B antibody positivity" ; rdfs:subClassOf obo:HP_0033558 . obo:HP_0033594 obo:IAO_0000115 "An abnormally increased amount of 7-biopterin in the urine." ; dc:date "2021-01-30T13:02:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Primapterinuria" ; a owl:Class ; rdfs:label "Elevated urinary 7-biopterin level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0033595 obo:IAO_0000115 "Increased concentration of globotriaosylceramide (Gb3) in the blood circulation. Globotriaosylceramide, also named ceramidetrihexoside, is the primary lipid storage in Fabry disease." ; dc:date "2021-01-30T13:16:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating ceramidetrihexoside concentration" ; a owl:Class ; rdfs:label "Elevated circulating globotriaosylceramide concentration" ; rdfs:subClassOf obo:HP_0004343 . obo:HP_0033596 obo:IAO_0000115 "An abnormally increased amount of 3-methylcrotonylglycine in the urine." ; dc:date "2021-01-30T13:24:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary 3-methylcrotonylglycine level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0033597 obo:IAO_0000115 "Reduced activity of the linked disaccharidase, sucrase-isomaltase, which is a glycoprotein localized to the brush border membrane of small intestinal villi." ; dc:date "2021-01-30T13:48:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sucrase-isomaltase has two subunits, sucrase and isomaltase. Isomaltase cleaves branched (1-6 linked) alpha-limit dextrins, while sucrase digests sucrose, maltose, short 1-4 linked glucose oligomers, and some branched starches into sugar monomers for intestinal absorption. Deficiency of this enzyme can lead to osmotic diarrhea, mild steatorrhea, chronic diarrhea, irritability, and vomiting after consuming sucrose." ; rdfs:label "Decreased mucosal sucrase-isomaltase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0033598 obo:IAO_0000115 "Fibrillar deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:16:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrillar glomerular subepithelial deposits" ; rdfs:subClassOf obo:HP_0033603 . obo:HP_0033599 obo:IAO_0000115 "A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:44:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular amyloid subepithelial deposits" ; rdfs:subClassOf obo:HP_0033598 . obo:HP_0033600 obo:IAO_0000115 "A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:47:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrillary glomerular subepithelial deposits" ; rdfs:subClassOf obo:HP_0033598 . obo:HP_0033601 obo:IAO_0000115 "A type of glomerular subepithelial deposit characterized by finely granular material deposited between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM and corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:51:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular subepithelial immune-complex deposits" ; rdfs:subClassOf obo:HP_0033603 . obo:HP_0033602 obo:IAO_0000115 "A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:54:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular hyaline subepithelial deposits" ; rdfs:subClassOf obo:HP_0033603 . obo:HP_0033603 obo:IAO_0000115 "Deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature may be associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." ; dc:date "2021-01-30T14:55:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular subepithelial deposits" ; rdfs:subClassOf obo:HP_0030949 . obo:HP_0033604 obo:IAO_0000115 "Glomerulus showing markedly and irregularly thickened capillary walls with massive fuchsinophilic subendothelial deposits, resulting in narrowing of capillary lumina. This feature is said to resemble a wire loop." ; dc:date "2021-01-30T16:24:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glomerular capillary wire loop deposits" ; rdfs:subClassOf obo:HP_0030949 . obo:HP_0033605 obo:IAO_0000115 "A rash composed of pustular lesions. A pustule is defined as a vesicle or bulla containing purulent material. It varies in size and may occur at different levels within the epidermis: subcorneal, intraepidermal, or basement membrane zones. The pustules may or may not be sterile and are normally filled with neutrophils." ; dc:date "2021-01-30T16:59:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Pustulosis" ; a owl:Class ; rdfs:label "Pustular rash" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0033606 obo:IAO_0000115 "Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow." ; dc:date "2021-01-30T21:26:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Haematopoietic maturation arrest", "Hematopoietic maturation arrest" ; a owl:Class ; rdfs:label "Bone marrow maturation arrest" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0033607 obo:IAO_0000115 "A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow." ; dc:date "2021-01-30T21:32:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bone marrow arrest at the promyelocytic stage" ; rdfs:subClassOf obo:HP_0033606 . obo:HP_0033608 obo:IAO_0000115 "Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging." ; dc:date "2021-01-30T22:05:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spot on the lung" ; a owl:Class ; rdfs:label "Pulmonary nodule" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033609 obo:IAO_0000115 "A type of pulmonary nodule whose density obscures the underlying parenchyma and thus has a \"solid\" appearance." ; dc:date "2021-01-30T22:14:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Solid pulmonary nodule" ; rdfs:subClassOf obo:HP_0033608 . obo:HP_0033610 obo:IAO_0000115 "Pulmonary subsolid nodules (SSNs) refer to pulmonary nodules with pure ground-glass nodules and part-solid ground-glass nodules. A ground-glass nodule (GGN) is the morphologic description of a pulmonary nodule category on thin-section chest computed tomography (CT). During the past decade, the natural history, management strategy and long-term prognosis in the case of GGNs have attracted attention." ; dc:date "2021-01-30T22:17:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subsolid pulmonary nodule" ; rdfs:subClassOf obo:HP_0033608 . obo:HP_0033611 obo:IAO_0000115 "Part-solid pulmonary nodules are nodules that present with both ground-glass and solid components in which the underlying lung architecture cannot be visualized." ; dc:date "2021-01-30T22:22:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Part-solid pulmonary nodule" ; rdfs:subClassOf obo:HP_0033610 . obo:HP_0033612 obo:IAO_0000115 "Pure ground-glass pulmonary nodules (GGNs) are defined as focal nodular areas of increased lung attenuation through which lung parenchymal structures, such as the pulmonary vessels or bronchial structures, can be observed." ; dc:date "2021-01-30T22:26:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pure ground-glass pulmonary nodule" ; rdfs:subClassOf obo:HP_0033610 . obo:HP_0033613 obo:IAO_0000115 "Solid, homogenous nodules characterised by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes." ; dc:date "2021-01-30T22:28:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perifissural pulmonary nodule" ; rdfs:subClassOf obo:HP_0033608 . obo:HP_0033614 obo:IAO_0000115 "Aberrant or accessory bronchus supplying the upper lobe originating from the lateral wall of the trachea. The tracheal bronchus is more commonly right-sided, has a variable length and may be blind-ended. Two common types of tracheal bronchus are: supernumerary and displaced." ; dc:date "2021-01-30T22:30:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tracheal bronchus" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033615 obo:IAO_0000115 "Accessory bronchus originating from trachea replacing one of the segmental branches of the anatomically normal upper lobe bronchus." ; dc:date "2021-01-30T22:31:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Displaced tracheal bronchus" ; rdfs:subClassOf obo:HP_0033614 . obo:HP_0033616 obo:IAO_0000115 "Accessory bronchus originating from the medial wall of the right or left ban bronchus or bronchus intermedius. A cardiac bronchus is usually blind-ended." ; dc:date "2021-01-30T22:33:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Accessory cardiac bronchus" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033617 obo:IAO_0000115 "Accessory bronchus which exits the trachea in addition to an anatomically normal branching upper lobe bronchus." ; dc:date "2021-01-30T22:34:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Supernumerary tracheal bronchus" ; rdfs:subClassOf obo:HP_0033614 . obo:HP_0033618 obo:IAO_0000115 "Accessory entire right upper lobe bronchial system originating from the trachea with absent anatomically normal upper lobe bronchus." ; dc:date "2021-01-30T22:35:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bronchus suis", "Pig bronchus" ; a owl:Class ; rdfs:label "Displaced lobar tracheal bronchus" ; rdfs:subClassOf obo:HP_0033614 . obo:HP_0033619 obo:IAO_0000115 "A perifissural nodule that has contact with the interlobar septum (and is therefore considered typical)." ; dc:date "2021-01-30T22:37:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Typical perifissural nodule" ; rdfs:subClassOf obo:HP_0033613 . obo:HP_0033620 obo:IAO_0000115 "A perifissural nodule that does not have contact with the interlobar septum (and is therefore considered atypical)." ; dc:date "2021-01-30T22:39:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atypical perifissural nodule" ; rdfs:subClassOf obo:HP_0033613 . obo:HP_0033621 obo:IAO_0000115 "Bronchial diverticula are blind-ended outpouchings arising from the bronchial tree. They are commonly pulsion diverticula acquired related to chronic cough. Subcarinal air cyst is thought to represent a small main bronchial diverticulum." ; dc:date "2021-01-30T22:43:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchial diverticula" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0033622 obo:IAO_0000115 "A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin." ; dc:date "2021-01-30T23:00:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Migratory erythematous plaque" ; rdfs:subClassOf obo:HP_0010783 . obo:HP_0033623 obo:IAO_0000115 "Information about the delivery and health status at birth typically elicited as a part of the past medical history." ; dc:date "2021-01-30T23:06:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Birth history" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0033624 obo:IAO_0000115 "A congenital cytomegalovirus (CMV) infection of the newborn can follow either a primary or recurrent maternal infection. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. Affected infants may develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits." ; dc:date "2021-01-30T23:08:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "History of congenital cytomegalovirus infection" ; a owl:Class ; rdfs:label "History of congenital CMV infection" ; rdfs:subClassOf obo:HP_0033623 . obo:HP_0033625 obo:IAO_0000115 "A feeling of general unease or nervousness that may be triggered by a sense of vulnerability or instability which is perceived as threatening." ; dc:date "2021-01-30T23:12:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "It is difficult to give a precise definition of emotional insecurity, but it has beed defined as deficits in emotional reactivity (inability to develop an attitude of resistance or vigiliance in the presence of potentially threatening situations), behavior regulation (inappropriate behavioral response to threatening situations characterized by either overinvolvement in the situation or by the avoidance of it) and inappropriate internal representations (exaggerated conscious or unconscious schemas of potential danger)." ; rdfs:label "Emotional insecurity" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0033626 obo:IAO_0000115 "Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol)." ; dc:date "2021-01-30T23:17:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated non-HDL cholesterol concentration" ; a owl:Class ; rdfs:label "Increased non-HDL cholesterol concentration" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0033627 obo:IAO_0000115 "Concentration of harderoporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2021-01-30T23:27:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urine harderoporphyrin level" ; rdfs:subClassOf obo:HP_0010473 . obo:HP_0033628 obo:IAO_0000115 "Intermittent abdominal pain with diarrhea and/or constipation." ; dc:date "2021-01-30T23:29:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bowel irritability" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0033629 obo:IAO_0000115 "The presence of an antibody of subclass IgG4 in the blood circulation that is directed against the organism's own cells or tissues." ; dc:date "2021-01-31T18:32:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "IgG4 autoimmune antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033630 obo:IAO_0000115 "Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is \"cloudy\". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously." ; dc:date "2021-01-31T18:36:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mental clouding", "Mental fatigue", "Mental fog" ; a owl:Class ; rdfs:comment "Brain fog has been reported in a range of diseases including myalgic encephalomyelitis/chronic fatigue syndrome, non-celiac gluten disease, postural tachycardia syndrome, lupus, and COVID-19." ; rdfs:label "Brain fog" ; rdfs:subClassOf obo:HP_0100543 . obo:HP_0033631 obo:IAO_0000115 "Inflammation of the vertebrae (vertebral bodies) or spine." ; dc:date "2021-02-01T13:12:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spondylitis" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_212 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033632 obo:IAO_0000115 "Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath manouver. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi*(Fi tracer/Fa tracer). In this equation, Vi = inspired volume of tracer gas, Fi tracer= inspired fraction of tracer gas, Fa tracer = alveolar (exhaled) fraction of tracer gas." ; dc:date "2021-02-01T13:14:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Only a portion of each tidal volume (Vt) reaches the alveoli and participates in gas exchange. This is referred to as the alveolar volume (Va). The remainder, the so-called dead space volume (Vd), consists of gas that fills the upper and lower airways (anatomic dead space) or reaches nonperfused or relatively poorly perfused alveoli (alveolar dead space)." ; rdfs:label "Abnormal alveolar volume" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033633 obo:IAO_0000115 "An abnormal reduction in alveolar volume." ; dc:date "2021-02-01T13:16:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased alveolar volume" ; rdfs:subClassOf obo:HP_0033632 . obo:HP_0033634 obo:IAO_0000115 "An abnormal elevation in alveolar volume." ; dc:date "2021-02-01T13:19:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased alveolar volume" ; rdfs:subClassOf obo:HP_0033632 . obo:HP_0033635 obo:IAO_0000115 "Post-capillary pulmonary hypertension is a hemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP greater than 20 mmHg) and pulmonary artery wedge pressure (PAWP greater than 15 mmHg) and pulmonary vascular resistance (PVR less than 3 Wood units)." ; dc:date "2021-02-01T13:21:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Postcapillary pulmonary hypertension" ; a owl:Class ; rdfs:comment "Post-capillary hypertension resulting from left heart disease causes backpressure and increases the hydrostatic pressure in the pulmonary veins which eventually results in increased pressure in pulmonary arteries." ; rdfs:label "Post-capillary pulmonary hypertension" ; rdfs:subClassOf obo:HP_0004890 . obo:HP_0033636 obo:IAO_0000115 "Combined pre- and post-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary artery wedge pressure (PAWP over 15 mmHg) and pulmonary vascular resistance (PVR at least 3 Wodd units)." ; dc:date "2021-02-01T14:58:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Combined pre- and post-capillary pulmonary hypertension" ; rdfs:subClassOf obo:HP_0004890 . obo:HP_0033637 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endomysial tissue transglutaminase 2 (tTG2)." ; dc:date "2021-02-03T13:26:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-transglutaminase 2 antibody positivity" ; a owl:Class ; rdfs:label "Anti-endomysial antibody positivity" ; rdfs:subClassOf obo:HP_0033563 . obo:HP_0033638 obo:IAO_0000115 "Intralobular septal thickening is a computed tomography finding of increased width of the walls (septa) within a pulmonary lobule. Secondary pulmonary lobules represent a cluster of up to 30 acini 9 supplied by a common distal pulmonary artery and bronchiole. These clustered acini are bounded by interstitial fibrous septa (interlobular septa) which outline an irregular polyhedron of varying size between 1 and 2.5 cm. Interlobular septal thickening is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases. In contrast, intralobular septal thickening are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened. When numerous, they may appear as a fine reticular pattern." ; dc:date "2021-02-03T13:28:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intralobular lines" ; a owl:Class ; rdfs:comment "Intralobular lines may be seen in various conditions, including interstitial fibrosis and alveolar proteinosis." ; rdfs:label "Intralobular septal thickening" ; rdfs:subClassOf obo:HP_0033711 . obo:HP_0033639 obo:IAO_0000115 "Embolization of intravascular thrombus containing microorganisms into the pulmonary parenchyma via arterial system. Septic pulmonary embolism (PE) can be associated with multiple additional clinical manifestations such as fever, tachypnea, and hemoptysis. This HPO term refers to the finding of the septic embolus in the lung, which can be inferred from radiological findings. Typical radiographic features of septic PE include patchy air space lesions simulating non-specific bronchopneumonia; multiple ill defined round or wedge shaped densities of varying sizes from approximately 0.5 to 3.5 cm located peripherally; lesions abutting the pleura and located at the end of vessels (feeding vessel sign) seen on chest CT scans. Other pulmonary features suggesting septic PE include bilateral, occasional unilateral, rapid progression of cavities or abscess formations." ; dc:date "2021-02-03T13:30:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Septic pulmonary emboli" ; a owl:Class ; rdfs:label "Septic pulmonary embolism" ; rdfs:subClassOf obo:HP_0033553 . obo:HP_0033640 obo:IAO_0000115 "Erosion (loss of substance) of the acetabular subchondral cortical bone. The acetabulum is the concave surface that meets with the head of the femur, forming the hip joint." ; dc:date "2021-02-24T12:37:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Acetabular erosions" ; rdfs:subClassOf obo:HP_0003170 . obo:HP_0033641 obo:IAO_0000115 "Deposition of calcium salts in the leaflets (cusps) of the aortic valve." ; dc:date "2021-02-03T13:39:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aortic cusp calcification", "Aortic valve cusp calcification" ; a owl:Class ; rdfs:label "Aortic valve leaflet calcification" ; rdfs:subClassOf obo:HP_0004380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033642 obo:IAO_0000115 "Deposition of calcium salts in the leaflets (cusps) of the mitral valve." ; dc:date "2021-02-03T13:41:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mitral valve leaflet calcification" ; rdfs:subClassOf obo:HP_0004382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007151 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0033643 obo:IAO_0000115 "Increased concentation of very long-chain fatty acids in the blood circulation. Very long-chain fatty acids are fatty acids (FAs) with a chain-length of 22 or more carbons." ; dc:date "2021-02-24T12:39:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased plasma levels of very long-chain fatty acid" ; a owl:Class ; rdfs:label "Increased circulating very long-chain fatty acid concentration" ; rdfs:subClassOf obo:HP_0004359 . obo:HP_0033644 obo:IAO_0000115 "Increased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production." ; dc:date "2021-02-24T12:41:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating erythropoietin" ; a owl:Class ; rdfs:label "Elevated circulating erythropoietin concentration" ; rdfs:subClassOf obo:HP_0034442 . obo:HP_0033645 obo:IAO_0000115 "A developmental defect characterized by an abnormal cleft (V-shaped indentation of the stalklike part of the brain consisting of the medulla oblongata, the midbrain, and the pons." ; dc:date "2021-02-24T12:43:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Midline brainstem cleft" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0033646 obo:IAO_0000115 "Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum." ; dc:date "2021-02-24T12:45:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Agenesis of the hippocampal commissure" ; a owl:Class ; rdfs:label "Absent hippocampal commissure" ; rdfs:subClassOf obo:HP_0025100 . obo:HP_0033647 obo:IAO_0000115 "The silhouette sign is the absence of depiction of an anatomic soft-tissue border. It is caused by consolidation and/or atelectasis of the adjacent lung, by a large mass, or by contiguous pleural fluid. The silhouette sign results from the juxtaposition of structures of similar radiographic attenuation. The sign actually refers to the absence of a silhouette." ; dc:date "2021-02-24T12:47:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The silhouette sign is not always indicative of disease (eg, unexplained absence of right border of heart is seen in association with pectus excavatum and sometimes in healthy individuals). See Figure 67 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Silhouette sign" ; rdfs:subClassOf obo:HP_0033775 . obo:HP_0033648 obo:IAO_0000115 "A pseudocavity appears as an oval or round area of low attenuation in lung nodules, masses, or areas of consolidation that represent spared parenchyma, normal or ectatic bronchi, or focal emphysema rather than cavitation. These pseudocavities usually measure less than 1 cm in diameter. They have been described in patients with adenocarcinoma, bronchioloalveolar carcinoma, and benign conditions such as infectious pneumonia." ; dc:date "2021-02-24T12:49:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 57 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary pseudocavity" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033649 obo:IAO_0000115 "Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae." ; dc:date "2021-02-24T12:52:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Distal acinar emphysema" ; a owl:Class ; rdfs:comment "See Figure 47 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Paraseptal emphysema" ; rdfs:subClassOf obo:HP_0002097 . obo:HP_0033650 obo:IAO_0000115 """A parenchymal band is a linear opacity, usually 1-3 mm thick and up to 5 cm long that usually extends to the visceral pleura (which is often thickened and may be retracted at the site of contact). It reflects pleuroparenchymal fibrosis and is usually associated with distortion of the lung architecture. Parenchymal bands are most frequently encountered in individuals who have been exposed to asbestos.""" ; dc:date "2021-02-24T12:54:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 48 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary parenchymal band" ; rdfs:subClassOf obo:HP_0031457 . obo:HP_0033651 obo:IAO_0000115 "A mycetoma is a discrete mass of intertwined hyphae, usually of an Aspergillus species, matted together by mucus, fibrin, and cellular debris colonizing a cavity, usually from prior fibrocavitary disease (eg, tuberculosis or sarcoidosis). A mycetoma may move to a dependent location when the patient changes position and may show an air crescent sign. CT scans may show a spongelike pattern and foci of calcification in the mycetoma." ; dc:date "2021-02-24T12:56:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lung fungus ball" ; a owl:Class ; rdfs:comment "See Figure 40 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary mycetoma" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033652 obo:IAO_0000115 "A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway, most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans. Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis" ; dc:date "2021-02-24T12:58:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 15 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Broncholith" ; rdfs:subClassOf obo:HP_0025426, obo:HP_0031983 . obo:HP_0033653 obo:IAO_0000115 "A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (eg, bronchial atresia) or acquired (eg, obstructing cancer). A bronchocele is a tubular or branching Y-or V-shaped structure that may resemble a gloved finger. The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (eg, high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion." ; dc:date "2021-02-24T13:34:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 13 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Bronchocele" ; rdfs:subClassOf obo:HP_0025426, obo:HP_0031983 . obo:HP_0033654 obo:IAO_0000115 "Irregular and nodular thickening of interlobular septa reminiscent of a row of beads." ; dc:date "2021-02-24T13:44:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The beaded septum sign is frequently seen in lymphangitic spread of cancer and less often in sarcoidosis. See Figure 10 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Beaded septum sign" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033655 obo:IAO_0000115 "A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick." ; dc:date "2021-02-24T13:46:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary cavern" ; a owl:Class ; rdfs:comment "A pulmonary cavity can be caused by microorganisms (bacteria including mycobacteria, funghi, viruses, parasites), malignant processes or autoimmune disorders." ; rdfs:label "Pulmonary cavity" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033656 obo:IAO_0000115 "A juxtaphrenic peak is a small triangular opacity based at the apex of the dome of a hemidiaphragm, associated with upper lobe volume loss of any cause (eg, postirradiation fibrosis or upper lobectomy). It is most readily appreciated on a frontal chest radiograph. The peak is caused by upward retraction of the inferior accessory fissure or an intrapulmonary septum associated with the pulmonary ligament." ; dc:date "2021-02-24T13:48:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 32 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Juxtaphrenic peak" ; rdfs:subClassOf obo:HP_0031457 . obo:HP_0033657 obo:IAO_0000115 "Linear atelectasis is a focal area of subsegmental atelectasis with a linear configuration, almost always extending to the pleura. It is commonly horizontal but sometimes oblique or vertical. The thickness of the atelectasis may range from a few millimeters to more than 1 cm." ; dc:date "2021-02-24T13:50:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Discoid atelectasis", "Platelike atelectasis" ; a owl:Class ; rdfs:comment "See Figure 33 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Linear atelectasis" ; rdfs:subClassOf obo:HP_0100750 . obo:HP_0033658 obo:IAO_0000115 "Rounded atelectasis is rounded collapsed lung associated with invaginated fibrotic pleura and thickened and fibrotic interlobular septa. Most frequently, it is the consequence of an asbestos-induced exudative pleural effusion with resultant pleural scarring, but it may occur with any cause of pleural fibrosis. On chest radiographs, rounded atelectasis appears as a mass abutting a pleural surface, usually in the posterior part of a lower lobe. Distorted vessels have a curvilinear disposition as they converge on the mass (the comet tail sign). The degree of lobar retraction depends on the volume of atelectatic lung. It is almost invariably associated with other signs of pleural fibrosis (eg, blunting of costophrenic angle). CT is more sensitive for the detection and display of the characteristic features of rounded atelectasis. An additional sign is homogeneous uptake of contrast medium in the atelectatic lung." ; dc:date "2021-02-24T13:51:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blesovsky syndrome", "Comet tail sign", "Folded lung syndrome", "Helical atelectasis", "Pleural pseudotumor", "Pleuroma" ; a owl:Class ; rdfs:comment "See Figure 65 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Rounded atelectasis" ; rdfs:subClassOf obo:HP_0100750 . obo:HP_0033659 obo:IAO_0100001 "HP:0025391" ; dc:date "2021-02-27T14:32:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Crazy-paving pattern" ; owl:deprecated true . obo:HP_0033660 obo:IAO_0000115 "Tingling (often refered to as a pins and needles feeling) and numbness in the hand." ; dc:date "2021-02-27T14:33:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hand tingling" ; a owl:Class ; rdfs:label "Hand paresthesia" ; rdfs:subClassOf obo:HP_0031006 . obo:HP_0033661 obo:IAO_0000115 "An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass. The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis. However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer." ; dc:date "2021-02-27T14:34:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 3 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Air crescent" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033662 obo:IAO_0000115 "An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung. The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (eg, pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (eg, lymphoma)." ; dc:date "2021-02-27T14:36:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 2 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Air bronchogram" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033663 obo:IAO_0000115 "Air trapping is retention of air in the lung distal to an obstruction (usually partial). Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse." ; dc:date "2021-02-27T14:37:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Differentiation from areas of decreased attenuation resulting from hypoperfusion as a consequence of an occlusive vascular disorder (eg, chronic thromboembolism) may be problematic, but other findings of airways versus vascular disease are usually present. See Figure 4 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Air trapping" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033664 obo:IAO_0000115 "Gangliogliomas are rare tumors of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumors consisting of both dysplastic neuronal and neoplastic glial cells." ; dc:date "2021-02-28T14:45:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3788" ; a owl:Class ; rdfs:comment "Gangliogliomas are commonly found in the temporal lobe and may be associated with temporal lobe epilepsy." ; rdfs:label "Ganglioglioma" ; rdfs:subClassOf obo:HP_0025170 . obo:HP_0033665 obo:IAO_0000115 "A reduction in an individual's subjective assessment of his or her sense of well-being and ability to perform social roles." ; dc:date "2021-02-28T14:48:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Diminished health-related quality of life" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033666 obo:IAO_0000115 "A reduction in the ability to perform activities of daily living as compared to previous abilities because of functional deficits due to illness. The 36-item Short Form (SF-36) health survey questionnaire is one of many methods used to measure patients' perceptions of diminished physical functioning." ; dc:date "2021-02-28T14:50:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decline in physical functional health", "Diminished physical health" ; a owl:Class ; rdfs:label "Diminished physical functioning" ; rdfs:subClassOf obo:HP_0033665 . obo:HP_0033667 obo:IAO_0000115 "A reduction in the subjective feeling of mental well being." ; dc:date "2021-02-28T14:50:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mental impairment", "Reduced mental health" ; a owl:Class ; rdfs:comment "The WHO defines mental health as a state of well-being in which the individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to his or her community. Thus, mental health is not a state of absence of mental illness. Mental health has been defined on the basis of three components of mental health: emotional well-being, psychological well-being and social well-being. Alternatively, mental health can be defined as a dynamic state of internal equilibrium which enables individuals to use their abilities in harmony with universal values of society. Attempts to measure mental health in as objective a fashion as possible may involve questionnaires such as the 36-item Short Form (SF-36) health survey questionnaire. Impaired mental health is characterized by a reduction in the mental component score (MCS)." ; rdfs:label "Diminished mental health" ; rdfs:subClassOf obo:HP_0033665 . obo:HP_0033668 obo:IAO_0000115 "A structural anomaly of the amygdala." ; dc:date "2021-02-28T14:53:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal morphology of the amygdala" ; a owl:Class ; rdfs:comment "The amygdala is a centrally located brain region that plays fundamental roles in human emotion, memory, and various homeostatic responses. Situated in the rostral part of the temporal lobe and abutting the basal forebrain, the human amygdala is closely connected with olfactory structures, the hippocampal formation, basal ganglia, basal forebrain components including ventral striatum and nucleus basalis, insula, claustrum, hypothalamus, and various thalamic nuclei. The amygdala contributes to white matter tracts that stream nearby, including the anterior commissure, inferior longitudinal fasciculus, stria terminalis, and uncinate fasciculus." ; rdfs:label "Abnormal amygdala morphology" ; rdfs:subClassOf obo:HP_0007343 . obo:HP_0033669 obo:IAO_0000115 "A increase in the volume (size) of the amygdyla." ; dc:date "2021-02-28T14:56:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amygdalar enlargement" ; a owl:Class ; rdfs:comment "Amygdalar enlargement is observed in a minority of people with intractable temporal lobe epilepsy." ; rdfs:label "Enlarged amygdala" ; rdfs:subClassOf obo:HP_0033668 . obo:HP_0033670 obo:IAO_0000115 "Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities." ; dc:date "2021-02-28T14:59:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 45 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Organizing pneumonia" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033671 obo:IAO_0000115 "Oligemia is a reduction in pulmonary blood volume. Most frequently, this reduction is regional, but occasionally it is generalized. Regional oligemia is usually associated with reduced blood flow in the oligemic area. Oligemia appears as a regional or widespread decrease in the size and number of identifiable pulmonary vessels, which is indicative of less than normal blood flow." ; dc:date "2021-02-28T15:00:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 44 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary oligemia" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033672 obo:IAO_0000115 "The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve." ; dc:date "2021-02-28T15:02:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Positive carpal Hoffmann Tinel sign" ; a owl:Class ; rdfs:comment "Carpal tunnel syndrome is the most common entrapment neuropathy. The pain and paresthesias characterizing carpal tunnel syndrome are typically along the distribution of the median nerve (i.e., thumb, index finger, and middle finger). At times, these symptoms may occur in all the fingers, but should not occur in the dorsum or palm of the hand." ; rdfs:label "Positive carpal Tinel sign" ; rdfs:subClassOf obo:HP_0032120 . obo:HP_0033673 obo:IAO_0000115 "The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger)." ; dc:date "2021-02-28T15:04:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phalen maneuver", "Phalen manoeuvre" ; a owl:Class ; rdfs:comment "See Figure 2 of PMID:31773104." ; rdfs:label "Positive Phalen test" ; rdfs:subClassOf obo:HP_0032120 . obo:HP_0033674 obo:IAO_0000115 "Pulmonary blood flow redistribution refers to any departure from the normal distribution of blood flow in the lungs that is caused by an increase in pulmonary vascular resistance elsewhere in the pulmonary vascular bed. Pulmonary blood flow redistribution is indicated by a decrease in the size and/or number of visible pulmonary vessels in one or more lung regions, with a corresponding increase in number and/or size of pulmonary vessels in other parts of the lung." ; dc:date "2021-02-28T15:06:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Upper lobe blood diversion in patients with mitral valve disease is the archetypal example of redistribution. See Figure 59 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Pulmonary blood flow redistribution" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033675 obo:IAO_0000115 "A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised." ; dc:date "2021-03-01T15:45:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There is no objective test for frailty. An operational definition recognizes frailty in an individual who has three out of the following five criteria: (i) low grip strength; (ii) low energy; (iii) slowed waking speed; (iv) low physical activity; and (v) unintentional weight loss." ; rdfs:label "Frailty" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033676 obo:IAO_0000115 "A behavioral or psychological symptom that typically occurs following exposure to one or more traumatic events. Posttraumatic stress disorder (PTSD) symptoms include intrusive recollections (re-experiencing the trauma in flashbacks, memories or nightmares); avoidant and numbing symptoms (including diminished emotions and avoidance of situations that are reminders of the traumatic event); and hyperarousal (including increased irritability, exaggerated startle reactions or difficulty sleeping or concentrating)." ; dc:date "2021-03-02T00:54:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "PTSD" ; a owl:Class ; rdfs:comment "This term is intended to be used if no additional information is available. If possible, more specific terms should be used." ; rdfs:label "Posttraumatic stress symptom" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0033677 obo:IAO_0000115 "Acute respiratory distress syndrome (ARDS) is defined as an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300." ; dc:date "2021-03-03T20:15:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ARDS" ; a owl:Class ; rdfs:comment "Acute respiratory distress syndrome (ARDS) is a life-threatening condition of seriously ill patients, characterized by poor oxygenation, pulmonary infiltrates, and acuity of onset. On a microscopic level, the disorder is associated with capillary endothelial injury and diffuse alveolar damage. Once ARDS develops, patients usually have varying degrees of pulmonary artery vasoconstriction and may subsequently develop pulmonary hypertension. ARDS carries a high mortality, and few effective therapeutic modalities exist to combat this condition. ARDS can be observed as a complication of many diseases including pulmonary infection or aspiration, sepsis, trauma, massive transfusion, drowning, drug overdose, fat embolism, inhalation of toxic fumes, and pancreatitis." ; rdfs:label "Acute respiratory distress syndrome" ; rdfs:subClassOf obo:HP_0004887 . obo:HP_0033678 obo:IAO_0000115 "The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI)." ; dc:date "2021-03-03T20:22:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A diagnosis of NSTEMI can be made when the ischemia is sufficiently severe to cause myocardial damage that results in the release of a biomarker of myocardial necrosis into the circulation (cardiac-specific troponins T or I, or muscle and brain fraction of creatine kinase [CK-MB]). In contrast, the patient is considered to have experienced UA if no such biomarker can be detected in the bloodstream hours after the initial onset of ischemic chest pain. Unstable angina exhibits 1 or more of 3 principal presentations: (1) rest angina (usually lasting >20 minutes), (2) new-onset (<2 months previously) severe angina, and (3) a crescendo pattern of occurrence (increasing in intensity, duration, frequency, or any combination of these factors)." ; rdfs:label "Acute coronary syndrome" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0033679 obo:IAO_0000115 "Any structural anomaly of the red nucleus, a part of the midbrain involved in control of movement." ; dc:date "2021-03-06T13:01:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal red nucleus morphology" ; rdfs:subClassOf obo:HP_0002418 . obo:HP_0033680 obo:IAO_0000115 "The most common form of astrocytoma (WHO Grade I) in childhood. These typically have MAPK signalling pathway abnormalities." ; dc:date "2021-03-06T13:07:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C4047" ; a owl:Class ; rdfs:label "Pilocytic astrocytoma" ; rdfs:subClassOf obo:HP_0009592 . obo:HP_0033681 obo:IAO_0000115 "Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG." ; dc:date "2021-03-06T13:09:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3288" ; a owl:Class ; rdfs:label "Oligodendroglioma" ; rdfs:subClassOf obo:HP_0009733 . obo:HP_0033682 obo:IAO_0000115 "Pleomorphic xanthoastrocytomas (PXA) are rare low-grade astrocytomas (WHO Grade II) typically found in the temporal lobe and classically presenting with epilepsy. PXA is an astrocytic neoplasm that most often presents in children or young adults but can also occur in adults. The diagnosis of anaplastic PXA is made based upon tumor histopathologic characteristics and requires increased proliferative activity (mitotic index at least 5 mitoses/10 HPF), which is associated with worse overall survival. In general, anaplastic PXAs acquire features of a more aggressive astrocytic neoplasm that can include increased proliferation, necrosis, microvascular proliferation, loss of pericellular reticulin, and increased infiltrative growth." ; dc:date "2021-03-06T13:14:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleomorphic xanthoastrocytoma" ; rdfs:subClassOf obo:HP_0009592 . obo:HP_0033683 obo:IAO_0000115 "Increased intensity of muscle tendon reflexes in jaw." ; dc:date "2021-03-06T13:25:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Brisk jaw jerk" ; a owl:Class ; rdfs:label "Jaw hyperreflexia" ; rdfs:subClassOf obo:HP_0001347 . obo:HP_0033684 obo:IAO_0000115 "Ay deviation from the normal distribution of fiber types in skeletal muscle. The skeletal muscle groups of the mammalian body are made up of bundles of muscle fibers. These fibers can be assigned to different Types, with characteristic movement rates, response to neural inputs, and metabolic styles. Skeletal muscle fibers are broadly classified as slow-twitch (type 1) and fast-twitch (type 2). Multiple fiber types are generally intermingled within a single muscle group, and different muscle groups have varying proportions of fiber types" ; dc:date "2021-03-07T22:37:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal muscle fiber-type distribution" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0033685 obo:IAO_0000115 "An abnormal distribution of muscle fiber types in muscle tissue. Human skeletal muscle contains at least two fiber types recognizable by histochemical techniques. In transverse sections of normal skeletal muscle, type 1 and type 2 fibers are distributed in a random fashion. Grouping of fibers of the same type can be seen in certain peripheral neuropathies, thought to be due to reinnervation of denervated muscle fibers by sprouting axons. With grouping, motor units enlarge. The fibers of a motor unit, which are normally scattered, come to lie adjacent to one another. Histochemical examination shows groups of muscle fibers of the same histochemical type." ; dc:date "2021-03-07T22:40:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fibre type grouping" ; a owl:Class ; rdfs:label "Fiber type grouping" ; rdfs:subClassOf obo:HP_0033684 . obo:HP_0033686 obo:IAO_0000115 "Enlargment of mitochondria. Mitochondrial hypertrophy is not discernible by light microscopy. By electron microscopy (EM), hypertrophic mitochondria have normal cristae and normal matrix density. In contrast, swollen mitochondria display swollen cristae and irregular matrix densities in EM." ; dc:date "2021-03-07T22:44:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Megamitochondria" ; a owl:Class ; rdfs:label "Mitochondrial hypertrophy" ; rdfs:subClassOf obo:HP_0012087 . obo:HP_0033687 obo:IAO_0000115 "A deficit in the retention of pieces of information (memory chunks) for a relatively short time (usually up to 30 seconds)." ; dc:date "2021-03-07T22:47:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Short term memory loss" ; a owl:Class ; rdfs:comment "The impairment of short term memory (STM) involves forgetting information to which the subject has been recently exposed. An individual with signs of losing STM, indeed, asks for the same questions repeatedly, forgets where he just put something, forgets recent events or something he saw or read recently. The loss of immediate memory is also termed as fixation amnesia. Practically, STM works as a kind of scratchpad for temporary recall of a limited number of data that come from the sensory register and are ready to be processed through attention and recognition. On the other side, information collected in the long term memory (LTM) storage consist of memories for the performance of actions or skills (i.e., procedural memories, knowing how) and memories of facts, rules, concepts, and events (i.e., declarative memories, knowing that)." ; rdfs:label "Short term memory impairment" ; rdfs:subClassOf obo:HP_0002354 . obo:HP_0033688 obo:IAO_0000115 "A deficit in the ability to retrieve information from long-term memory, which can be defined as a seemingly unlimited capacity to store memories can last years and relate to the performance of actions or skills (i.e., procedural memories, knowing how) and memories of facts, rules, concepts, and events (i.e., declarative memories, knowing that)." ; dc:date "2021-03-07T22:48:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Long term memory loss" ; a owl:Class ; rdfs:label "Long term memory impairment" ; rdfs:subClassOf obo:HP_0002354 . obo:HP_0033689 obo:IAO_0000115 "The impaired ability to establish new long-term memories." ; dc:date "2021-03-07T22:50:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anterograde amnesia" ; a owl:Class ; rdfs:label "Anterograde memory impairment" ; rdfs:subClassOf obo:HP_0033688 . obo:HP_0033690 obo:IAO_0000115 "Inability to retrieve information from the long-term memory that was acquired before the onset of amnesia." ; dc:date "2021-03-07T22:53:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Retrograde amnesia" ; a owl:Class ; rdfs:label "Retrograde memory impairment" ; rdfs:subClassOf obo:HP_0033688 . obo:HP_0033691 obo:IAO_0000115 "A reduction in the ability to retrieve information about how to perform activities, such as how to ride a bike or drive a car, how to perform activities of daily living, or how to play a musical instrument." ; dc:date "2021-03-07T22:55:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired procedural memory", "Procedural memory deficit" ; a owl:Class ; rdfs:label "Procedural memory loss" ; rdfs:subClassOf obo:HP_0033690 . obo:HP_0033692 obo:IAO_0000115 "Impaired ability to remember facts and events." ; dc:date "2021-03-07T22:56:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Impaired declarative memory" ; a owl:Class ; rdfs:label "Declarative memory loss" ; rdfs:subClassOf obo:HP_0033690 . obo:HP_0033693 obo:IAO_0000115 "Perception of an odor in the absence of any stimuli in the surrounding environment that could emit the odor." ; dc:date "2021-03-07T22:57:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Olfactory hallucination", "Phantom odor", "Phantom odour", "Phantom smell" ; a owl:Class ; rdfs:comment "Phantosmia has been documented in individuals with epileptic seizures, schizophrenia, depression, migraine, and otorhinolaryngology problems. Phantosmia occurs in a variety of clinical conditions, and its causes are yet unknown. Prior accounts have suggested that the phantosmic sensations originate either in the peripheral olfactory nervous system or in central brain regions, such as the amygdala and the orbital frontal cortex. Patients who experienced phantosmia following head trauma were characterized by left frontal atrophy, suggestive of a cortical origin. However, a patient study reported successfully resolving phantosmia in 7 out of 8 patients through excision of the olfactory epithelium, suggesting also peripheral olfactory system involvement." ; rdfs:label "Phantosmia" ; rdfs:subClassOf obo:HP_0004408 . obo:HP_0033694 obo:IAO_0000115 "The false perception of tactile sensory input that creates a hallucinatory sensation of physical contact with an imaginary object." ; dc:date "2021-03-07T23:00:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tactile hallucinations" ; a owl:Class ; rdfs:comment "There are many different types of tactile hallucination. A common one is formication, the sensation like insects crawling over the skin (derived from the Latin word for ant, formica)." ; rdfs:label "Tactile hallucination" ; rdfs:subClassOf obo:HP_0000738 . obo:HP_0033695 obo:IAO_0000115 "This is a general term that denotes a reduced ability to perform the work that one performed prior to an illness, and may be related to pain, cognitive dysfunction, fatigue or other physical disabilities." ; dc:date "2021-03-07T23:02:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term does not intend to include or exclude legal definitions of occupational disability. It is included in the HPO because inability to work is a frequent manifestation of disease comparable in some ways to impairment of activities of daily living." ; rdfs:label "Occupational disability" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033696 obo:IAO_0000115 "Acral areas of erythema with vesicles or pustules. The lesions resemble chilblains and have purpuric areas, affecting hands and feet." ; dc:date "2021-03-07T23:03:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chilblain-like lesion" ; a owl:Class ; rdfs:comment "This condition is termed pseudo-chilblain because of the similar appearance of these lesions to chilblains. Pseudochilblains may be observed in persons with COVID-19 without documented exposure to cold or other risk factors for chilblains." ; rdfs:label "Pseudo-chilblain" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0033697 obo:IAO_0000115 "A type of acute-onset skin rash characterized by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point. The fluid contained in a vesicle may be clear, serous, or hemorrhagic." ; dc:date "2021-03-07T23:06:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vesicular eruption" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0033698 obo:IAO_0000115 "A type of vesicular eruption in which the vesicles are at same stages." ; dc:date "2021-03-07T23:07:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Monomorphic vesicular eruptions should be differentiated from polymorphic vesicular eruptions such as those seem in chickenpox." ; rdfs:label "Monomorphic vesicular eruption" ; rdfs:subClassOf obo:HP_0033697 . obo:HP_0033699 obo:IAO_0000115 "A type of vesicular eruption in which the vesicles are at different stages." ; dc:date "2021-03-07T23:09:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be seen in many diseases including chickenpox." ; rdfs:label "Polymorphic vesicular eruption" ; rdfs:subClassOf obo:HP_0033697 . obo:HP_0033700 obo:IAO_0000115 "An acute onset rash characterized by by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevations with a diameter less than 10mm at the widest point, and by multiple papules, which are circumscribed, solid epidermal elevations with no visible fluid with a diameter less than 10mm at the widest point." ; dc:date "2021-03-07T23:10:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Papulo-vesicular eruption" ; a owl:Class ; rdfs:label "Papulovesicular eruption" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0033701 obo:IAO_0000115 "Increased density related to increased bone mass in the outermost layer (edge) of the iliac wing." ; dc:date "2021-03-12T12:07:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 3B of PMID:17404618." ; rdfs:label "Cortical sclerosis of the iliac wing" ; rdfs:subClassOf obo:HP_0011867 . obo:HP_0033702 obo:IAO_0000115 "This finding is a thin curvilinear opacity, 1-3 mm in thickness, lying less than 1 cm from and parallel to the pleural surface. It corresponds to atelectasis of normal lung if seen in the dependent posteroinferior portion of lung of a patient in the supine position and is subsequently shown to disappear on CT sections acquired with the patient prone. It may also be encountered in patients with pulmonary edema or fibrosis (other signs are usually present)." ; dc:date "2021-03-12T12:28:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Though described in the context of asbestosis, subpleural curvilinear line is not specific for asbestosis. See Figure 68 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Subpleural curvilinear line" ; rdfs:subClassOf obo:HP_0031457, obo:HP_0031630 . obo:HP_0033703 obo:IAO_0000115 "Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Lesions vary in size from 10 to 25 mm, although occasionally larger tumors of up to 70 mm have been reported. Grossly, tumors appear as well-defined, solitary nodular masses or poorly demarcated lesions. On the cut section, most tumors are cortically located and may extend into the underlying subcortical white matter in larger tumors. Multi-nodular appearance or cystic changes are commonly found" ; dc:date "2021-03-12T12:40:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "DNET", "DNT" ; a owl:Class ; rdfs:comment "They are commonly found in the temporal lobe and may be associated with temporal lobe epilepsy. DNETs are sometimes found in association with focal cortical dysplasia and have both neuronal and glial features." ; rdfs:label "Dysembryoplastic neuroepithelial tumor" ; rdfs:subClassOf obo:HP_0025170 . obo:HP_0033704 obo:IAO_0000115 "An increased amount of homogentisic acid in the urine." ; dc:date "2021-03-12T12:47:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This finding is characteristic for alkaptonuria." ; rdfs:label "Elevated urinary homogentisic acid" ; rdfs:subClassOf obo:HP_0033303 . obo:HP_0033705 obo:IAO_0000115 "A feeling of sadness characterized by crying episodes that can come on suddenly and are not under usual social control." ; dc:date "2021-03-12T13:20:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tearfulness" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0033706 obo:IAO_0000115 """This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in the upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis.""" ; dc:date "2021-03-31T10:46:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 56 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722." ; rdfs:label "Progressive massive fibrosis" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033707 obo:IAO_0000115 "Increased thickness of the stratum corneum (the outer layer of the skin) in the skin surrounding the mouth." ; dc:date "2021-03-31T11:24:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perioral hyperkeratosis" ; rdfs:subClassOf obo:HP_0034521 . obo:HP_0033708 dc:date "2021-03-31T11:32:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibodies", "Anti-HMGCR autoantibodies" ; a owl:Class ; rdfs:label "Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033709 obo:IAO_0000115 "An increase in the amount of airway mucus. This feature may be characterized by frequent or excessive throat clearing (exhalation through tightly constricted laryngopharyngeal tissues accompanied by vibration of the palatoglossal arch and the vocal folds serving to clear mucus from the airway)." ; dc:date "2021-03-31T12:40:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased phlegm" ; a owl:Class ; rdfs:comment "If excessive sputum production is manifested by frequent and often involuntary coughing, the HPO term Productive cough should be used." ; rdfs:label "Increased sputum production" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0033710 obo:IAO_0000115 "A perception of shortness of breath that occurs independently of exertion." ; dc:date "2021-04-05T14:49:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Breathlessness at rest", "Dyspnea at rest", "Dyspnoea at rest", "Shortness of breath at rest" ; a owl:Class ; rdfs:label "Rest dyspnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0033711 obo:IAO_0000115 "Pathological thickening of the pulmonary interstitium visualized radiographically and divided into interlobular and intralobular septal thickening." ; dc:date "2021-04-05T18:17:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary interstitial thickening" ; rdfs:subClassOf obo:HP_0025389 . obo:HP_0033712 obo:IAO_0000115 "Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles." ; dc:date "2021-04-07T11:40:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Recurrent implantation failure" ; a owl:Class ; rdfs:comment "Successful embryo implantation is a process which requires both a synchronous development and interaction between hatched blastocyst and endometrium. From the clinical point of view, implantation is considered to be successful when gestational sac is diagnosed by ultrasound." ; rdfs:label "Repeated implantation failure" ; rdfs:subClassOf obo:HP_0033335 . obo:HP_0033713 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against anti-signal recognition particle." ; dc:date "2021-04-07T11:44:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-SRP antibody positivity" ; a owl:Class ; rdfs:label "Anti-signal recognition particle antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0033714 obo:IAO_0000115 "The occurrence of multiple distinct meningiomas in the same individual." ; dc:date "2021-04-07T11:50:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multifocal meningiomata", "Multiple meningiomata" ; a owl:Class ; rdfs:label "Multiple meningiomas" ; rdfs:subClassOf obo:HP_0002858 . obo:HP_0033715 obo:IAO_0000115 "Hippocampal sclerosis is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus." ; dc:date "2021-04-07T12:37:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mesial temporal sclerosis" ; a owl:Class ; rdfs:comment "Hippocampal sclerosis is now recognized as one of the main causes of focal epilepsy and is present in approximately 10% of adults with new-onset focal epilepsy." ; rdfs:label "Hippocampal sclerosis" ; rdfs:subClassOf obo:HP_0002171, obo:HP_0025100 . obo:HP_0033716 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the frontal region." ; dc:date "2021-04-07T12:41:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with frontal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033717 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the temporal region." ; dc:date "2021-04-07T12:56:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with temporal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033718 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the central region." ; dc:date "2021-04-07T12:58:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with central epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033719 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the parietal region." ; dc:date "2021-04-07T12:59:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with parietal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033720 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the occipital region." ; dc:date "2021-04-07T13:02:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with occipital epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033721 obo:IAO_0000115 "Focal epileptiform EEG discharges recorded in the centrotemporal region." ; dc:date "2021-04-07T13:05:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "EEG with centrotemporal epileptiform discharges" ; rdfs:subClassOf obo:HP_0011185 . obo:HP_0033722 obo:IAO_0000115 "An autonomic epileptic aura is a purely subjective manifestation of an epileptic seizure pertaining to autonomic nervous system function. Autonomic auras include cardiorespiratory (e.g., palpitations and shortness of breath), gastrointestinal, genitourinary (genital sensations, urinary urge), and cutaneous (feeling of warmth or cold) sensations. Abdominal auras constitute the most common type of autonomic aura. These include sensations of nausea, pain, or indescribable discomfort in the abdominal or periumbilical area that can be static, rise to the chest and throat, or descend into the lower abdominal region." ; dc:date "2021-04-07T13:09:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Autonomic aura", "Autonomic auras", "Vegetative aura" ; a owl:Class ; rdfs:comment "As an aura, its manifestation is purely subjective, conversely the initial manifestation of a focal autonomic seizure (HP:0011154) may be objective (a physical sign) or subjective (a symptom). Consider the following additional more specific annotations: types of 'focal aware autonomic seizure' (HP:0032740) if the aura occurs as the sole manifestation of the seizure, types of 'focal impaired awareness autonomic seizure' (HP:0032755) if the seizure progresses with impairment of awareness, and 'bilateral tonic-clonic seizure with focal onset' (HP:0007334) if the seizure propagates into a bilateral tonic-clonic seizure." ; rdfs:label "Autonomic epileptic aura" ; rdfs:subClassOf obo:HP_0011154, obo:HP_0033348 . obo:HP_0033723 obo:IAO_0000115 "Abnormal structure of the venous sinuses that drain blood from the cerebral veins and cerebrospinal fluid (CSF) from the arachnoid granulations to the internal jugular veins." ; dc:date "2021-04-07T16:31:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal dural venous sinus morphology", "Abnormality of the cerebral venous sinuses" ; a owl:Class ; rdfs:label "Abnormal cerebral venous sinus morphology" ; rdfs:subClassOf obo:HP_0012480 . obo:HP_0033724 obo:IAO_0000115 "An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses." ; dc:date "2021-04-07T16:35:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cerebral venous sinus thrombosis" ; rdfs:subClassOf obo:HP_0004936, obo:HP_0033723 . obo:HP_0033725 obo:IAO_0000115 "An abnormally thin corpus callous, due to atrophy, hypoplasia or agenesis. This term is intended to be used in situations where it is not known if thinning of the corpus callosum (for instance, as visualized by magnetic resonance tomography) is due to abnormal development (e.g. a leukodystrophy) or atrophy following normal development (e.g. neurodegeneration)." ; dc:date "2021-04-07T16:39:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Small corpus callosum", "Thinning of the corpus callosum" ; a owl:Class ; rdfs:label "Thin corpus callosum" ; rdfs:subClassOf obo:HP_0001273 . obo:HP_0033726 obo:IAO_0000115 "Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management." ; dc:date "2021-04-16T13:23:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lupus nephritis" ; rdfs:subClassOf obo:HP_0000099 . obo:HP_0033727 obo:IAO_0000115 "A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations." ; dc:date "2021-04-16T13:34:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class IV lupus nephritis" ; a owl:Class ; rdfs:label "Diffuse lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033728 obo:IAO_0000115 "A subclass of lupus nephritis with purely mesangial hypercellularity of any degree or mesangial matrix expansion by lightmicroscopy, with mesangial immune deposits. A few isolated subepithelial or subendothelial deposits may be visible by immunoflourescence or electron microscopy, but not by light microscopy." ; dc:date "2021-04-16T13:36:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class II lupus nephritis" ; a owl:Class ; rdfs:label "Mesangial proliferative lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033729 obo:IAO_0000115 "A subclass of lupus nephritis with normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence." ; dc:date "2021-04-16T13:41:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class I lupus nephritis" ; a owl:Class ; rdfs:label "Minimal mesangial lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033730 obo:IAO_0000115 "A lupus nephritis subclass with global or segmental subepithelial immune deposits or their morphological sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. May occur in combination with class III or IV, in which case both classes are diagnosed. May show advanced sclerosis" ; dc:date "2021-04-16T13:42:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class V lupus nephritis" ; a owl:Class ; rdfs:label "Membranous lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033731 obo:IAO_0000115 "A subclass of lupus nephritis with active or inactive focal, segmental or global endocapillary or extracapillary glomerulonephritis involving less than 50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations" ; dc:date "2021-04-16T13:45:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class III lupus nephritis" ; a owl:Class ; rdfs:label "Focal lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033732 obo:IAO_0000115 "A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity." ; dc:date "2021-04-16T13:47:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Class VI lupus nephritis" ; a owl:Class ; rdfs:label "Advanced sclerotic lupus nephritis" ; rdfs:subClassOf obo:HP_0033726 . obo:HP_0033733 obo:IAO_0000115 "Vesicoureteral reflux without dilation of the renal calyces (Grade I-II)." ; dc:date "2021-04-16T13:55:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Low-grade vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0000076 . obo:HP_0033734 obo:IAO_0000115 "Vesicoureteral reflux with dilation of the renal calyces (Grade III - V)." ; dc:date "2021-04-16T13:56:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "High-grade vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0000076 . obo:HP_0033735 obo:IAO_0000115 "Vesicoureteral reflux into the ureter only." ; dc:date "2021-04-16T13:58:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade I VUR", "VUR I" ; a owl:Class ; rdfs:label "Grade I vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0033733 . obo:HP_0033736 obo:IAO_0000115 "Vesicoureteral reflux into a non-dilated pyelocalyceal system." ; dc:date "2021-04-16T14:00:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade II VUR", "VUR II" ; a owl:Class ; rdfs:label "Grade II vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0033733 . obo:HP_0033737 obo:IAO_0000115 "Vesicoureteral reflux with dilatation of the collecting system." ; dc:date "2021-04-16T14:04:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade III VUR", "VUR III" ; a owl:Class ; rdfs:label "Grade III vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0033734 . obo:HP_0033738 obo:IAO_0000115 "Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction." ; dc:date "2021-04-16T14:07:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term can be used together with a term to describe the grade of VUR." ; rdfs:label "Primary vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0000076 . obo:HP_0033739 obo:IAO_0000115 "Vesicoureteral reflux induced by increased bladder pressures in patients with voiding dysfunction e.g. in case of congenital posterior urethral valves or neurogenic bladder dysfunction." ; dc:date "2021-04-16T14:09:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term can be used together with a term to describe the grade of VUR." ; rdfs:label "Secondary vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0000076 . obo:HP_0033740 obo:IAO_0000115 "Vesicoureteral reflux with massive dilation of the collecting system and severe tortuosity of the ureter." ; dc:date "2021-04-16T14:12:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade V VUR", "VUR V" ; a owl:Class ; rdfs:label "Grade V vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0033734 . obo:HP_0033741 obo:IAO_0000115 "Vesicoureteral reflux with more-extensive dilation with blunting of the calyces and tortuosity of the ureter." ; dc:date "2021-04-16T14:15:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade IV VUR", "VUR IV" ; a owl:Class ; rdfs:label "Grade IV vesicoureteral reflux" ; rdfs:subClassOf obo:HP_0033734 . obo:HP_0033742 obo:IAO_0000115 "Severe vesicoureteral reflux reaching the kidney parenchyma." ; dc:date "2021-04-16T14:19:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intrarenal reflux" ; rdfs:subClassOf obo:HP_0033734 . obo:HP_0033743 obo:IAO_0000115 "A congenital defect characterized by lack of development of the macula." ; dc:date "2021-04-16T14:35:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Macular agenesis" ; rdfs:subClassOf obo:HP_0008059 . obo:HP_0033744 obo:IAO_0000115 "A type of cerebellar dysplasia that affects the entire cerebellum." ; dc:date "2021-04-16T21:54:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Global cerebellar dysplasia" ; rdfs:subClassOf obo:HP_0007033 . obo:HP_0033745 obo:IAO_0000115 "A type of cerebellar dysplasia that affects the upper part of the cerebellar vermis." ; dc:date "2021-04-16T21:56:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Dysplasia of the superior cerebellar vermis is generally seen in Joubert syndrome." ; rdfs:label "Dysplasia of the superior cerebellar vermis" ; rdfs:subClassOf obo:HP_0002334, obo:HP_0007033 . obo:HP_0033746 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the area between the shoulder blades." ; dc:date "2021-04-19T22:53:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pain between shoulder blades" ; a owl:Class ; rdfs:label "Intrascapular pain" ; rdfs:subClassOf obo:HP_0003418 . obo:HP_0033747 obo:IAO_0000115 "A type of somatic sensory dysfunction characterized by abnormality of superficial sensation that is mediated by receptors in skin and mucous membranes." ; dc:date "2021-04-21T10:58:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal exteroceptive sensation" ; rdfs:subClassOf obo:HP_0003474 . obo:HP_0033748 obo:IAO_0000115 "Decreased ability to perceive touch." ; dc:date "2021-04-21T11:10:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoaesthesia", "Numbness" ; a owl:Class ; rdfs:comment "In hte literature, hypoesthesia is not used specifically to denote loss of tactile sensation, but can be used to refer to losses of all types of sensation. Here, we use the term to refer to exteroceptive sensation." ; rdfs:label "Hypoesthesia" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0033749 obo:IAO_0000115 "A deviation from normal values for the functional residual capacity, which is defined as the volume remaining in the lungs after a normal, passive exhalation." ; dc:date "2021-04-21T15:47:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Functional residual capacity (FRC), is about 3L in a normal adult. FRC is the total amount of air in a person's lungs at the lowest point of their tidal volume (TV; the volume of air a person normally inspires and expires). The FRC is a lung capacity, consisting of the sum of two or more volumes. It also cannot be measured directly using spirometry and has to be calculated. This because FRC is a combination of the expiratory reserve volume (ERV) and the residual volume (RV). The residual volume is the amount of air remaining the lung after expelling as much air from the lungs as possible. The residual volume can never be exhaled; thus, it cannot be measured using spirometry and is the air causing the alveoli to remain open. The ERV is the reserve amount of air that can be exhaled forcefully, after passive exhalation. Therefore, the FRC can be represented as the equation: FRC=RV+ERV." ; rdfs:label "Abnormal functional residual capacity" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033750 obo:IAO_0000115 "An abnormal reduction in the volume remaining in the lungs after a normal, passive exhalation." ; dc:date "2021-04-21T15:49:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced functional residual capacity" ; rdfs:subClassOf obo:HP_0033749 . obo:HP_0033751 obo:IAO_0000115 "An abnormal increase in the volume remaining in the lungs after a normal, passive exhalation." ; dc:date "2021-04-21T15:49:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated functional residual capacity" ; rdfs:subClassOf obo:HP_0033749 . obo:HP_0033752 obo:IAO_0000115 "Any deviation from normal values of the residual volume, which is defined as the volume of air left in the lungs at the end of maximal expiration (ie. the volume of air which you cannot voluntarily exhale from your lungs)." ; dc:date "2021-04-21T16:09:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal residual volume" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033753 obo:IAO_0000115 "Abnormal decrease in the amount of air remaining in a person's lungs after full exhalation." ; dc:date "2021-04-21T16:11:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced residual volume" ; rdfs:subClassOf obo:HP_0033752 . obo:HP_0033754 obo:IAO_0000115 "Any deviation from the normal range of end-diastolic volume of the left ventricle, which is the volume of blood in the left ventricle at the end of diastole (just before systole)." ; dc:date "2021-04-22T19:06:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal left ventricular end-diastolic volume" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0033755 obo:IAO_0000115 "Abnormally high volume of blood in the left ventricle at the end of diastole (just before systole)." ; dc:date "2021-04-22T19:22:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased left ventricular end-diastolic volume" ; rdfs:subClassOf obo:HP_0033754 . obo:HP_0033756 obo:IAO_0000115 "Abnormally low volume of blood in the left ventricle at the end of diastole (just before systole)." ; dc:date "2021-04-22T19:23:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased left ventricular end-diastolic volume" ; rdfs:subClassOf obo:HP_0033754 . obo:HP_0033757 obo:IAO_0000115 "Fat infiltration in the pancreas." ; dc:date "2021-04-22T22:17:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fatty pancreas", "Non-alcoholic fatty pancreatic disease", "Pancreatic fatty infiltration", "Pancreatic fatty replacement", "Pancreatic lipomatosis", "Pancreatic lipomatous pseudohypertrophy" ; a owl:Class ; rdfs:comment "Pancreatic steatosis is the most common benign pathologic condition of the pancreas in adult and commonly related to obesity and associated insulin resistance." ; rdfs:label "Pancreatic steatosis" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0033758 obo:IAO_0000115 "A circumscribed area of pus or necrotic debris in the labia." ; dc:date "2021-04-28T13:04:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abscess of the labia" ; a owl:Class ; rdfs:label "Labial abscess" ; rdfs:subClassOf obo:HP_0033587 . obo:HP_0033759 obo:IAO_0000115 "Decreased renal tubular reabsorption of magnesium." ; dc:date "2021-04-28T13:05:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "96% of filtered magnesium is reabsorbed in the tubule. 10%-30% of the filtered magnesium is absorbed in the proximal tubule, the thick ascending limb absorbs 40%-70% of filtered magnesium." ; rdfs:label "Impaired renal tubular reabsorption of magnesium" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0033760 obo:IAO_0000115 "Maximum oxygen uptake (VO2max) is defined as the highest rate of oxygen uptake and utilization by the body during intense, maximal exercise, whereby further increases in work rate do not bring on additional rises in VO2 (i.e. plateau). VO2Max is typically measured with a treadmill anad ergometer and the participant exercises with increasing levels of intensity. VO2Max is the point at which oxygen uptake no longer increases despite an increase in workload." ; dc:date "2021-04-29T21:47:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased maximal oxygen uptake" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033761 obo:IAO_0000115 "Xanthogranulomatous pyelonephritis is a granulomatous inflammatory infiltrate composed of neutrophils, lymphocytes, plasma cells, xanthomatous histiocytes, and multinucleated giant cells." ; dc:date "2021-04-30T11:02:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Xanthogranulomatous pyelonephritis is an uncommon chronic destructive granulomatous process of renal parenchyma in association with long-term urinary tract obstruction and infection." ; rdfs:label "Xanthogranulomatous pyelonephritis" ; rdfs:subClassOf obo:HP_0012330 . obo:HP_0033762 obo:IAO_0000115 "Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain." ; dc:date "2021-04-30T11:06:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Middle cerebral artery stroke" ; rdfs:subClassOf obo:HP_0001297 . obo:HP_0033763 obo:IAO_0000115 "Cessation of life at the age of 16 years or later." ; dc:date "2021-04-30T11:20:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Death in adulthood" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0033764 obo:IAO_0000115 "Death between the age of 40 and 60 years." ; dc:date "2021-04-30T11:20:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Death in middle age" ; rdfs:subClassOf obo:HP_0033763 . obo:HP_0033765 obo:IAO_0000115 "Death at an age of at least 60 years." ; dc:date "2021-04-30T11:21:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Death in late adulthood" ; rdfs:subClassOf obo:HP_0033763 . obo:HP_0033766 obo:IAO_0000115 "Polymelia is a congenital anomaly, which is defined as the presence of accessory limbs attached to various body regions and could be classified as cephalomelia (extra-limb attached to the head), notomelia (extra-limb attached to the back bone), thoracomelia (extra-limb attached to the thorax), and pyromelia (extra-limb attached to the pelvis)." ; dc:date "2021-04-30T11:21:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Polymelia" ; rdfs:subClassOf obo:HP_0040064 . obo:HP_0033767 obo:IAO_0000115 "Abnormally high or low single motor unit action potential reading (-Pk Amps)." ; dc:date "2021-04-30T11:50:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal single motor unit action potential" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0033768 obo:IAO_0000115 "Overgrowth of candida albicans in the penis." ; dc:date "2021-04-30T11:53:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Penile candidiasis" ; a owl:Class ; rdfs:label "Penile thrush" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0033769 obo:IAO_0000115 "Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps." ; dc:date "2021-04-30T13:21:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fundic gland polyps", "Gastric polyposis", "Proximal polyposis of the stomach" ; a owl:Class ; rdfs:label "Fundic gland polyposis" ; rdfs:subClassOf obo:HP_0006753 . obo:HP_0033770 obo:IAO_0000115 "An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia." ; dc:date "2021-04-30T14:02:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Ninety percent of all tumors of the stomach are malignant, and gastric adenocarcinoma comprises 95% of the total number of malignancies." ; rdfs:label "Gastric adenocarcinoma" ; rdfs:subClassOf obo:HP_0006753 . obo:HP_0033771 obo:IAO_0000115 "Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling." ; dc:date "2021-05-01T15:26:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleuritic chest pain" ; rdfs:subClassOf obo:HP_0100749 . obo:HP_0033772 obo:IAO_0000115 "Any deviation from the normal ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography." ; dc:date "2021-05-01T15:42:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal RV/TLC ratio" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0033773 obo:IAO_0000115 "An abnormally low ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining after maximal expiration and TLC is the total amount of air in the lungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography." ; dc:date "2021-05-01T15:44:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased RV/TLC ratio" ; rdfs:subClassOf obo:HP_0033772 . obo:HP_0033774 obo:IAO_0000115 "Decreased renal tubular reabsorption of uric acid." ; dc:date "2021-05-04T14:21:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Uric acid excretion rate is the product of the filtered load (which can be approximated as plasma ultrafilterable urate multiplied by tge glomerular filtration rate) and fractional excretion of urate (FEUA), which represents the percentage of filtered urate that is excreted in the final urine." ; rdfs:label "Impaired renal tubular reabsorption of uric acid" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0033775 obo:IAO_0000115 "An abnormal pulmonary imaging finding defined by eponym or reference to signs, symbols, or naturalistic images." ; dc:date "2021-05-04T14:47:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary imaging sign" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033776 obo:IAO_0000115 "Small nodules of enamel on the root of a tooth." ; dc:date "2021-05-07T09:49:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Enamel pearls can typically not be seen on X-rays but need direct visualization. The pearls can be present on the surface of the dentine or cement of deciduous teeth, with a frequency of 33% or on the roots of maxillary molars, with a frequency of 1.2%." ; rdfs:label "Enamel pearls" ; rdfs:subClassOf obo:HP_0000682 . obo:HP_0033777 obo:IAO_0000115 "Additional cusps of a dental crown." ; dc:date "2021-05-07T09:52:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Additional cusp", "Extra cusp" ; a owl:Class ; rdfs:comment "The crown is the part of the tooth that is visible in the oral cavity. Supernumerary cusps can occur on any tooth with cusps. Canines possess a single cusp, premolars two (bicuspid), and molars three to five cusps. Supernumerary cusps are frequently seen in patients with other dental anomalies. Prevalence varies by geographical region. A tubercle on the lingual surface of the maxillary first permanent molar is sometimes referred to as a Carabelli cusp. A supernumerary cusp on the lingual or palatal side of anterior teeth is called Talon cusp, and an additional cusp on the occlusal surface of a premolar is called Leung cusp." ; rdfs:label "Supernumerary cusp" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0033778 obo:IAO_0000115 "An additional cusp located in the middle of the occlusal surface." ; dc:date "2021-05-07T09:59:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A Leung cusp is present on premolars only. In radiographs, a pulp extension may be seen inside the cusp." ; rdfs:label "Leung cusp" ; rdfs:subClassOf obo:HP_0033777 . obo:HP_0033779 obo:IAO_0000115 "A tooth crown with convex mesial and distal surfaces." ; dc:date "2021-05-07T10:08:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A barrel shape of a tooth occurs in incisors and canines only. The incisal edge is not pointed. Barrel-shaped teeth are frequently observed in association with hypodontia and oligodontia." ; rdfs:label "Barrel-shaped tooth" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0033780 obo:IAO_0000115 "A tooth crown with a marked cervical area constriction." ; dc:date "2021-05-07T10:09:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bulbous tooth" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0033781 obo:IAO_0000115 "A tooth with a crown that narrows from proximal toward the incisal edge. Tapering of teeth typically involves incisors." ; dc:date "2021-05-07T10:14:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tapered tooth" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0033782 obo:IAO_0000115 "An incisor with a half-moon shape incisal edge." ; dc:date "2021-05-07T10:21:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Crescent-shape tooth", "Hutchinson incisor", "Semicircular tooth", "Tooth, semilunar" ; a owl:Class ; rdfs:comment "If a notch occupies most of incisal edge, it has been indicated as semilunar teeth or crescent-shaped." ; rdfs:label "Semilunar tooth" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0033783 obo:IAO_0000115 "Molar incisor malfomation (MIM) is composed of normal crown with marked cervical constriction, thin, narrow short roots which is a combination of signs that occurs in deciduous and permanent molars." ; dc:date "2021-05-07T10:32:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "MIM affects one or more roots of deciduous second molars and permanent first molars. Permanent maxillary central incisors may also be affected. The diagnosis requires clinical and radiographic examinations." ; rdfs:label "Molar incisor malformation" ; rdfs:subClassOf obo:HP_0011070 . obo:HP_0033784 obo:IAO_0000115 "This is a bundled term as dentin dysplasia is composed of short roots with pointed ends and taurodontism and intrapulpal calcifications." ; dc:date "2021-05-07T10:38:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term designates a genetic condition, and an Element of Morphology rending its utilization sometimes confusing. The condition is characterized by multiple dental anomalies that affect both deciduous and permanent dentitions. It can exist in isolation or be associated with other signs and symptoms of various syndromes." ; rdfs:label "Dentin dysplasia" ; rdfs:subClassOf obo:HP_0010299 . obo:HP_0033785 obo:IAO_0000115 "Complete or almost complete absence of enamel." ; dc:date "2021-05-07T10:59:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Enamel agenesis can indicate a total absence of enamel or the presence of a very thin enamel layer that is difficult to visualize during clinical examination. It may need microscopic studies to determine whether any enamel is still present. It can be present isolated and as part of rare syndromic entities." ; rdfs:label "Enamel agenesis" ; rdfs:subClassOf obo:HP_0000682 . obo:HP_0033786 obo:IAO_0000115 "Enamel with a white or brown discoloration without hypoplasia." ; dc:date "2021-05-07T11:02:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Enamel opacity" ; a owl:Class ; rdfs:comment "Enamel maturation is a process through which enamel matrix proteins are removed to allow full growth of the enamel hydroxyapatite crystals. Hypomature enamel can be caused by genetic or environmental factors. It may occur in both deciduous and permanent dentitions, although more often in the permanent dentition. Hypomature enamel may concern a single tooth, several teeth, or the complete dentition and may affect part or the complete surface of the tooth. The enamel is usually hard, colored but not translucid. It is a qualitative defect of enamel." ; rdfs:label "Hypomature enamel" ; rdfs:subClassOf obo:HP_0000682 . obo:HP_0033787 obo:IAO_0000115 "The decrease or absence of cementum. The cementum anchors the periodontal ligament attachment fiber between the tooth root and the alveolar bone. Its absence leads to early loss of teeth." ; dc:date "2021-05-07T11:07:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cementum aplasia" ; a owl:Class ; rdfs:label "Cementum hypoplasia" ; rdfs:subClassOf obo:HP_0100717 . obo:HP_0033788 obo:IAO_0000115 "Excess of cementum on the tooth root surface." ; dc:date "2021-05-07T11:08:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cementation hyperplasia", "Cementum hypertrophy", "Cementum overdeveloped", "Drumstick-shaped root", "Hypercementosis" ; a owl:Class ; rdfs:comment "The excessive buildup of normal cementum (calcified tissue) on the roots of one or more teeth is an idiopathic, non-neoplastic condition. Cementum overgrowth may be either hyperplasia or hypertrophy of the cement; these terms can only be used if histological evidence of hypertrophy or hyperplasia have been established." ; rdfs:label "Cementum overgrowth" ; rdfs:subClassOf obo:HP_0100717 . obo:HP_0033789 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating cheese." ; dc:date "2021-05-07T11:11:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cheese contains tyramine, which is thought to be responsible for tachycardia and hypertension that can be tirggered by eating cheese in persons with Trimethylaminuria." ; rdfs:label "Triggered by cheese ingestion" ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0033790 obo:IAO_0000115 "A thistle tube shape of the pulp chamber, meaning an enlarged coronal pulp chamber with narrow pulp canals giving a radiographic appearance of the shape of a thistle tube or a flame. It may occur isolated or associated with other dental anomalies and rare diseases such as dentinogenesis imperfecta, which should be assessed and coded separately. The diagnosis thistle tube shape pulp requires clinical and radiographic examinations." ; dc:date "2021-05-07T11:14:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flame-shaped pulp" ; a owl:Class ; rdfs:label "Thistle tube shaped pulp" ; rdfs:subClassOf obo:HP_0006479 . obo:HP_0033791 obo:IAO_0000115 "Fusion of a tooth with alveolar bone." ; dc:date "2021-05-07T11:24:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Ankylosis is uncommon in the deciduous dentition and very rare in the permanent dentition. It may be observed after trauma. Ankylosis may occur at the crown or root level." ; rdfs:label "Tooth ankylosis" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0033792 obo:IAO_0000115 "Lingual occlusion of buccal cusps and/or incisal edge of maxillary teeth to the buccal cusps and/or incisal edge of mandibular teeth." ; dc:date "2021-05-07T11:30:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cross bite may occur unilaterally, bilaterally, or frontally. A total cross bite with buccal displacement of the maxillary posterior teeth, with or without contact between the lingual surface of the maxillary lingual cusp and the buccal surface of the buccal cusp of its mandibular antagonist, has been called scissor bite. If only a single tooth is affected, the term single cross bite can be used." ; rdfs:label "Cross bite" ; rdfs:subClassOf obo:HP_0000692 . obo:HP_0033793 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating a certain food." ; dc:date "2021-05-07T17:28:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by food ingestion" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0033794 obo:IAO_0000115 "Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargment, glove tightness, and hand enlargement." ; dc:date "2021-05-08T12:21:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acral enlargement", "Acral hypertrophy", "Acromegalic growth" ; oboInOwl:hasRelatedSynonym "Acromegaly" ; a owl:Class ; rdfs:comment "This term should be used to encode the overgrowth of hands and feet that can be seen in acromegaly, a rare disorder caused by excessive growth hormone production, most commonly from an adenoma of the anterior pituitary gland. The resulting production of insulin-like growth factor 1 causes the characteristic overgrowth of certain tissues resulting in coarsening of facial features, enlarging hands and feet, as well as effects on multiple systems throughout the body. The Figure in PMID:30853479 illustrates large hands with stubby fingers characteristic of acromegaly." ; rdfs:label "Acral overgrowth" ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0033795 dc:date "2021-05-09T11:28:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Growth hormone (GH) is essential for normal growth. However, cases of normal growth without GH may occur. The mechanism of growth without GH remains still unclear. However, regarding normal growth without GH arising after brain surgery, hypothalamic damage caused by the brain surgery is thought to induce obesity, and the resulting hyperinsulinemia and/or hyperprolactinemia are assumed to be important mechanisms of normal growth without GH in postsurgery patients. It is assumed that elevated insulin and/or prolactin concentration normalize IGF-1 levels even in GHD patients, restricts the increase in serum levels of IGFBP-3, and changes the distribution of circulating IGF-1. Thus, normal growth without GH continues because of the effects of IFG-I, which are independent of GH." ; rdfs:label "Growth without growth hormone" ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0033796 obo:IAO_0000115 "A functional abnormality of a white blood cell." ; dc:date "2021-05-08T13:50:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal leukocyte physiology" ; rdfs:subClassOf obo:HP_0001871, obo:HP_0010978 . obo:HP_0033797 obo:IAO_0000115 "Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization." ; dc:date "2021-05-08T13:51:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal leukocyte migration", "Defects of leukocyte migration" ; a owl:Class ; rdfs:label "Leukocyte migration defect" ; rdfs:subClassOf obo:HP_0033796 . obo:HP_0033798 obo:IAO_0000115 "During states of inflammation, white blood cells (leukocytes) play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. This term refers to a defect in the attachment of leukocytes to the blood vessel wall, which is a key step required before they can pass through gaps of the endothelial cells of the blood vessel wall to migrate to the site of inflammation." ; dc:date "2021-05-08T13:55:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired leukocyte adhesion" ; rdfs:subClassOf obo:HP_0033797 . obo:HP_0033799 obo:IAO_0000115 "Any deviation from the normal concentration of a sex hormone in the blood circulation" ; dc:date "2021-05-09T11:33:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating gonadal steroid concentration", "Abnormal circulating gonadocorticoid concentration", "Abnormal circulating sex steroid concentration" ; a owl:Class ; rdfs:comment "Sex hormones are steroid hormones that include the androgens, estrogens, and progestogens." ; rdfs:label "Abnormal circulating sex hormone concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0033800 obo:IAO_0000115 "Blistering (presence of multiple fluid filled blisters) categorized according to the body site where they occur." ; dc:date "2021-05-08T14:53:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blistering by anatomical location" ; rdfs:subClassOf obo:HP_0008066 . obo:HP_0033801 obo:IAO_0000115 "Blistering (presence of multiple fluid filled blisters) categorized according to the layer of the skin in which the blister originates. The skin is divided into three layers. The epidermis (outermost layer, which mainly consists of keratinocytes), the dermis, and a subcutaneous layer. The epidermis is divided into five layers: the basal lamina (innermost layer), the basal cell layer, the stratum spinosum, the stratum granulosum, and the stratum corneum (outermost layer). Cleavage in epidermolysis bullosa (EB) simplex occurs within the basal keratinocytes; in junctional EB, within the lamina lucida; and in dystrophic EB occurs in the sublamina densa, in the upper portion of the dermis (papillary dermis). In Kindler's EB, cleavage can occur in the basal keratinocytes, in the lamina lucida, or below the lamina densa." ; dc:date "2021-05-08T14:55:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blistering by histological location" ; rdfs:subClassOf obo:HP_0008066 . obo:HP_0033802 obo:IAO_0000115 "A type of blistering in which the lesions are located within the epidermis with loss of cell-cell adhesion of keratinocytes. In simplex EB, cleavage occurs in the basal layer, which is the innermost layer of the epidermis and consists of a single layer of basal germinative cells (mostly epidermal Keratinocytes) that proliferate and thereby produce new cells for other epidermal layers. As the cells move towards the upper layers of the epidermis they mature and eventually form cornified cells. The suprabasal cell layer lies directly above the basal layer and is composed of five to ten layers of cells." ; dc:date "2021-05-08T14:57:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intra-epidermal blistering" ; rdfs:subClassOf obo:HP_0033801 . obo:HP_0033803 obo:IAO_0000115 "A type of blistering in which the cleavage plane of blisters is located below the lamina densa." ; dc:date "2021-05-08T15:00:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blistering with sub-lamina densa plane of cleavage" ; a owl:Class ; rdfs:comment "Cleavage in the sublamina densa, in the upper portion of the dermis (papillary dermis), occurs in dystrophic epidermolysis bullosa." ; rdfs:label "Sub-lamina densa cleavage" ; rdfs:subClassOf obo:HP_0033804 . obo:HP_0033804 obo:IAO_0000115 "A type of blistering in which the lesions are located beneath the epidermis." ; dc:date "2021-05-08T15:09:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subepidermal blistering" ; rdfs:subClassOf obo:HP_0033801 . obo:HP_0033805 obo:IAO_0000115 "A granuloma which is not associated with necrotic changes." ; dc:date "2021-05-08T15:11:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Non-necrotizing granuloma" ; rdfs:subClassOf obo:HP_0032252 . obo:HP_0033806 obo:IAO_0000115 "An abnormal structure of the stratum granulosum, which is is a thin layer of cells in the epidermis lying above the stratum spinosum and below the stratum corneum." ; dc:date "2021-05-08T15:13:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal epidermis stratum granulosum morphology" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0033807 obo:IAO_0000115 "Lack of keratohyalin granules, which are normally present in the stratum granulosum of the epidermal layer of the skin." ; dc:date "2021-05-08T15:15:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Keratohyalin granules typically contain a mixture of keratin filament bundles, as well as the filament-associated proteins loricrin, filaggrin, and trichohyalin. These granules are insoluble in water and located within the cytoplasm where they promote dehydration of the cell. Their chief function seems to be cross-linking of keratin filaments which creates the tight barrier that is the epidermis, providing the body with an impermeable layer that protects from invasion by foreign particles. This process of cornification of the epidermis effected by KHG is known as keratinization." ; rdfs:label "Absent keratohyalin granules" ; rdfs:subClassOf obo:HP_0033806 . obo:HP_0033808 obo:IAO_0000115 "A cystic structure arising from the epididymis, rete testis or efferent ductuli. These structures are filled with spermatozoa containing fluid that may be milky. These cysts are usually outside the tunica vaginalis and, as with hydrocele, transluminate easily." ; dc:date "2021-05-08T15:33:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Spermatoceles are frequently seen on scrotal ultrasound as an incidental finding and may be present in up to 30% of patients." ; rdfs:label "Spermatocele" ; rdfs:subClassOf obo:HP_0009714 . obo:HP_0033809 obo:IAO_0000115 "Increased concentration of 17alpha-hydroxypregnenolone in the blood circulation. 17alpha-hydroxypregnenolone is a 21-carbon steroid that is converted from pregnenolone by steroid 17-alpha-hydroxylase, as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids." ; dc:date "2021-05-09T11:41:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Increased concentration of 17 hydroxypregnolone level can be observed in conditions including cytochrome P450 oxidoreductase deficiency." ; rdfs:label "Increased circulating 17 hydroxypregnenolone concentration" ; rdfs:subClassOf obo:HP_0031187 . obo:HP_0033810 obo:IAO_0000115 "A reduced concentration of dihydrotestosterone in the blood circulation." ; dc:date "2021-05-09T11:44:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating dihydrotestosterone concentration" ; rdfs:subClassOf obo:HP_0030349 . obo:HP_0033811 obo:IAO_0000115 "Any deviation from the normal concentration of androstenedione in the blood circulation." ; dc:date "2021-05-09T11:53:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating androstenedione concentration" ; rdfs:subClassOf obo:HP_0030347 . obo:HP_0033812 obo:IAO_0000115 "Reduced concentration of androstenedione in the blood circulation." ; dc:date "2021-05-09T11:56:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating androstenedione concentration" ; rdfs:subClassOf obo:HP_0033811 . obo:HP_0033813 obo:IAO_0000115 "Situated or occurring around a lobe of an organ." ; dc:date "2021-05-09T12:03:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perilobular" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033814 obo:IAO_0000115 "Characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa." ; dc:date "2021-05-09T12:08:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paraseptal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033815 obo:IAO_0000115 "Centered in bronchi or bronchioles." ; dc:date "2021-05-09T12:11:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bronchocentric" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033816 obo:IAO_0000115 "Located in the center of the secondary pulmonary lobules, which are the functional units of the lungs." ; dc:date "2021-05-09T12:12:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Centrilobular" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033817 obo:IAO_0000115 "Characterized by numerous small lesions said to resemble millet seed." ; dc:date "2021-05-09T12:13:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Miliary" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033818 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance resembles a net or network-like structure." ; dc:date "2021-05-09T12:18:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reticular" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033819 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance are located at or near lymphatic structures (node or vessel)." ; dc:date "2021-05-09T12:19:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perilymphatic" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033820 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance are located at the apex of an organ. For instance, apical refers to the superior portion of the lung." ; dc:date "2021-05-09T12:20:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Apical" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0033821 obo:IAO_0000115 "A mass in the lung seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics)." ; dc:date "2021-05-09T12:22:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary mass" ; rdfs:subClassOf obo:HP_0033822 . obo:HP_0033822 obo:IAO_0000115 """A mass is any pulmonary, pleural, or mediastinal lesion seen on chest radiographs as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics). Mass usually implies a solid or partly solid opacity. CT allows more exact evaluation of size, location, attenuation, and other features.""" ; dc:date "2021-05-09T12:24:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mass on thoracic imaging" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0033823 obo:IAO_0000115 "A mass in the mediastinum seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics)." ; dc:date "2021-05-09T12:25:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mediastinal mass" ; rdfs:subClassOf obo:HP_0033822 . obo:HP_0033824 obo:IAO_0000115 "A mass in the pleura seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics)." ; dc:date "2021-05-09T12:26:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pleural mass" ; rdfs:subClassOf obo:HP_0033822 . obo:HP_0033825 obo:IAO_0000115 "A type of mediastinal mass that is located above the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4)." ; dc:date "2021-05-09T12:26:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior mediastinal mass" ; rdfs:subClassOf obo:HP_0033823 . obo:HP_0033826 obo:IAO_0000115 "A type of mediastinal mass that is located below the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4)." ; dc:date "2021-05-09T12:28:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inferior mediastinal mass" ; rdfs:subClassOf obo:HP_0033823 . obo:HP_0033827 obo:IAO_0000115 "A type of inferior mediastinal mass that is located in front of the pericardium." ; dc:date "2021-05-09T12:29:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anterior mediastinal mass" ; rdfs:subClassOf obo:HP_0033826 . obo:HP_0033828 obo:IAO_0000115 "A type of inferior mediastinal mass that is located withinthe pericardium." ; dc:date "2021-05-09T12:29:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Middle mediastinal mass" ; rdfs:subClassOf obo:HP_0033826 . obo:HP_0033829 obo:IAO_0000115 "A type of inferior mediastinal mass that is located behind the pericardium." ; dc:date "2021-05-09T12:30:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Posterior mediastinal mass" ; rdfs:subClassOf obo:HP_0033826 . obo:HP_0033830 obo:IAO_0000115 "A type of pulmonary mass with high attenuation." ; dc:date "2021-05-09T12:32:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperdense pulmonary mass" ; rdfs:subClassOf obo:HP_0033821 . obo:HP_0033831 obo:IAO_0000115 "Thick-walled abnormal gas-filled interstitial mass within a lung with a diameter greater than 30 mm." ; dc:date "2021-05-09T12:33:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cavitating pulmonary mass" ; rdfs:subClassOf obo:HP_0033655, obo:HP_0033821 . obo:HP_0033832 obo:IAO_0000115 "A reddish-blue mottled condition of skin caused by inflammation of the cutaneous blood vessels." ; dc:date "2021-05-09T12:35:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Livedoid dermatitis" ; a owl:Class ; rdfs:label "Livedo" ; rdfs:subClassOf obo:HP_0011276 . obo:HP_0033833 obo:IAO_0000115 "Increased concentration of the interleukin-2 receptor alpha-chain (CD25) in the blood circulation. CD25 is shed upon immune activation. Increased levels of soluble CD25, therefore, are an indication of an on-going immune response." ; dc:date "2021-05-16T15:23:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating interleukin-2 receptor alpha-chain" ; a owl:Class ; rdfs:label "Elevated circulating soluble CD25 concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0033834 obo:IAO_0000115 "A feeling of general discomfort, weakness, or lack of health." ; dc:date "2021-05-16T15:40:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Malaise" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033835 obo:IAO_0000115 "Anomalous structure of a blood vessel in the kidney." ; dc:date "2021-05-16T17:27:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal vascular morphology" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0033836 obo:IAO_0000115 "An anomalous structure of an artery located in the kidney." ; dc:date "2021-05-16T17:29:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal kidney arterial blood vessel morphology" ; a owl:Class ; rdfs:label "Abnormal intrarenal artery morphology" ; rdfs:subClassOf obo:HP_0033835 . obo:HP_0033837 obo:IAO_0000115 "Anomalous structure of the arc-shaped arteries located at the border of the renal cortex and renal medulla." ; dc:date "2021-05-16T17:30:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormalities of arcuate arteries" ; a owl:Class ; rdfs:label "Abnormal arcuate artery morphology" ; rdfs:subClassOf obo:HP_0033836 . obo:HP_0033838 obo:IAO_0000115 "A state of feeling very unhappy, uneasy, or dissatisfied." ; dc:date "2021-05-21T17:48:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dysphoria" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0033839 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to one or both testes." ; dc:date "2021-05-30T15:33:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pain in testicles" ; a owl:Class ; rdfs:label "Testicular pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0033840 obo:IAO_0000115 "Uterine bleeding that occurs after at least one year of amenorrhea in a woman who is not receiving hormone therapy." ; dc:date "2021-05-30T15:51:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Postmenopausal bleeding" ; rdfs:subClassOf obo:HP_0030012 . obo:HP_0033841 obo:IAO_0000115 "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching in the region of the eye." ; dc:date "2021-05-30T16:32:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Itchy eyes", "Ocular itch" ; a owl:Class ; rdfs:label "Ocular pruritus" ; rdfs:subClassOf obo:HP_0000989 . obo:HP_0033842 obo:IAO_0000115 "The condition of being unable to eat a full meal because of a feeling of fullness (satiety), or or feeling very full after eating only a small amount of food." ; dc:date "2021-05-30T20:36:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Feeling full quickly when eating", "Not able to finish a normal-sized meal" ; a owl:Class ; rdfs:label "Early satiety" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0033843 obo:IAO_0000115 "Feeling excessively full after meals." ; dc:date "2021-05-30T20:40:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Postprandial fullness" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0033844 obo:IAO_0000115 "The sensation that thoughts are moving too quickly." ; dc:date "2021-05-30T21:10:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Racing thoughts" ; a owl:Class ; rdfs:label "Tachyphrenia" ; rdfs:subClassOf obo:HP_0100543 . obo:HP_0033845 obo:IAO_0000115 "A feeling that something life-threatening or tragic is about to occur." ; dc:date "2021-06-01T16:27:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sense of doom" ; a owl:Class ; rdfs:label "Sense of impending doom" ; rdfs:subClassOf obo:HP_0100852 . obo:HP_0033846 obo:IAO_0000115 "Reduced amount of myelin in the spinal cord resulting from defective myelinogenesis." ; dc:date "2021-06-01T16:29:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spinal hypomyelination" ; rdfs:subClassOf obo:HP_0003429 . obo:HP_0033847 obo:IAO_0000115 "A form of altered taste sensation in which the affected person perceives a taste, usually an unpleasant one, in the absence of a corresponding stimulus in the environment." ; dc:date "2021-06-01T16:48:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phantom taste" ; a owl:Class ; rdfs:comment "In contrast to parageusia, phantageusia is not triggered by an environmental stimulus." ; rdfs:label "Phantageusia" ; rdfs:subClassOf obo:HP_0000223 . obo:HP_0033848 obo:IAO_0000115 "A type of aphasia that is characterized by impaired language comprehension." ; dc:date "2021-06-01T16:53:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fluent aphasia", "Wernicke aphasia" ; a owl:Class ; rdfs:label "Receptive aphasia" ; rdfs:subClassOf obo:HP_0002381 . obo:HP_0033849 obo:IAO_0000115 "The term bilingual aphasia is used to refer to aphasia in persons who speak two or more languages. When a multilingual speaker has aphasia following a stroke, the languages spoken premorbidly may show comparable or differential patterns of impairment. Differential patterns may manifest as greater impairment in one language compared to another, or as differences in the characteristics of aphasia. Clinical reports of bilingual aphasia show dissociations in the processing of the language learned first (L1) and and second (L2), with one language more impaired than the other. Other cases show a pattern of differential recovery where L2 is recovered only after L1. Another pattern is alternating antagonism; i.e., patients access one language in spontaneous speech and inhibit the other language for alternating periods. This term should be used for a type of aphasia in a person who speaks multiple languages in which the impairment is different for different languages." ; dc:date "2021-06-01T18:43:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bilingual aphasia" ; rdfs:subClassOf obo:HP_0002381 . obo:HP_0033850 obo:IAO_0000115 "Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness." ; dc:date "2021-06-02T17:59:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cold skin temperature", "Cool skin", "Cool skin temperature", "Coolness to palpation" ; a owl:Class ; rdfs:comment "Coldness is a nonspecific finding, but can be a sing of peripheral vascular disease with a reduction in blood perfusion resulting in relative coldness of the affected body part (usually a hand or foot or an extremity)." ; rdfs:label "Coldness" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0033851 obo:IAO_0000115 "Elevation of the upper eyelid on attempted downward gaze or adduction, adduction of the eye on attempted upward or downward gaze, and constriction of the pupil on attempted adduction." ; dc:date "2021-06-02T18:07:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oculomotor synkinesis" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0033852 obo:IAO_0000115 "Abnormal structure of a vein located inside the kidney parenchyma." ; dc:date "2021-06-02T18:53:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal intrarenal vein morphology" ; rdfs:subClassOf obo:HP_0033835 . obo:HP_0033853 obo:IAO_0000115 "Any structural anomaly of the arcuate vein. The arcuate veins cross traverse along the corticomedullary junction (at the border of the kideny cortex and medulla)." ; dc:date "2021-06-02T18:55:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal arcuate vein morphology" ; rdfs:subClassOf obo:HP_0033852 . obo:HP_0033854 obo:IAO_0000115 "Any structural anomaly of the interlobular veins of the kidney. An interlobular vein is surrounded by the renal cortex and located between renal lobules (consisting of the nephrons surrounding a single medullary ray and draining into a single collecting duct)." ; dc:date "2021-06-02T18:58:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal interlobular vein morphology" ; rdfs:subClassOf obo:HP_0033852 . obo:HP_0033855 obo:IAO_0000115 "Any structural anomaly located in the the inside space of the interlobular veins of the kidney." ; dc:date "2021-06-02T19:00:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal morphology of the interlobular vein lumen" ; a owl:Class ; rdfs:label "Abnormal interlobular vein lumen morphology" ; rdfs:subClassOf obo:HP_0033854 . obo:HP_0033856 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of interlobular veins. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-02T19:03:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cholesterol emboli within interlobular vein lumen" ; rdfs:subClassOf obo:HP_0033855 . obo:HP_0033857 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen of the interlobular veins of the kidney." ; dc:date "2021-06-02T19:06:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intraluminal thrombi within interlobular veins" ; rdfs:subClassOf obo:HP_0033855 . obo:HP_0033858 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the interlobular veins of the kidney." ; dc:date "2021-06-02T19:07:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Organized thrombi within interlobular vein lumen" ; rdfs:subClassOf obo:HP_0033855 . obo:HP_0033859 obo:IAO_0000115 "Anomalous structure of the capillaries that are derived from the efferent arteriole, forming a capillary network that surrounds the distal portions of the nephron tubule," ; dc:date "2021-06-23T17:32:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal peritubular capillary morphology" ; rdfs:subClassOf obo:HP_0033835 . obo:HP_0033860 obo:IAO_0000115 "Anomalous structure of the peritubular capillaries located in the cortex of the kidney." ; dc:date "2021-06-23T17:35:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cortical peritubular capillary morphology" ; rdfs:subClassOf obo:HP_0033859 . obo:HP_0033861 obo:IAO_0000115 "Duplicated basement membranes of the peritubular capillaries located in the cortex of the kidney and arranged in multiple concentric layers." ; dc:date "2021-06-23T17:37:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multilamellation of basement membranes within cortical peritubular capillaries" ; a owl:Class ; rdfs:label "Multilamellation of cortical peritubular capillary basement membranes" ; rdfs:subClassOf obo:HP_0033860 . obo:HP_0033862 obo:IAO_0000115 "Inflammation of the peritubular capillaries in the cortex of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells." ; dc:date "2021-06-23T17:41:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical peritubular capillaritis" ; rdfs:subClassOf obo:HP_0033860 . obo:HP_0033863 obo:IAO_0000115 "Abnormal structural characteristics of the interior space of the peritubular capillary in the cortex of the kidney." ; dc:date "2021-06-23T17:44:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cortical peritubular capillary lumen morphology" ; rdfs:subClassOf obo:HP_0033860 . obo:HP_0033864 obo:IAO_0000115 "Anomalous structure of the peritubular capillaries located in the medulla of the kidney." ; dc:date "2021-06-23T17:46:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal medullary peritubular capillary morphology" ; rdfs:subClassOf obo:HP_0033859 . obo:HP_0033865 obo:IAO_0000115 "Inflammation of the peritubular capillaries in the medulla of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells." ; dc:date "2021-06-23T17:47:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medullary peritubular capillaritis" ; rdfs:subClassOf obo:HP_0033864 . obo:HP_0033866 obo:IAO_0000115 "Substantially increased numbers of red blood cells within capillaries surrounding tubules in the medulla of the kidney. This feature is assessed in histological images as the presence of numerous erythrocytes in a segment of the capillary such that the vessel appears to be congested (not open)." ; dc:date "2021-06-23T19:01:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medullary peritubular capillary erythrocyte congestion" ; rdfs:subClassOf obo:HP_0033864 . obo:HP_0033867 obo:IAO_0000115 "Duplicated basement membranes of the peritubular capillaries located in the medulla of the kidney and arranged in multiple concentric layers." ; dc:date "2021-06-23T19:02:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multilamellation of basement membranes within medullary peritubular capillaries" ; a owl:Class ; rdfs:label "Multilamellation of medullary peritubular capillary basement membranes" ; rdfs:subClassOf obo:HP_0033864 . obo:HP_0033868 obo:IAO_0000115 "Abnormal structural characteristics of the interior space of the peritubular capillary in the medulla of the kidney." ; dc:date "2021-06-23T19:04:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal medullary peritubular capillary lumen morphology" ; rdfs:subClassOf obo:HP_0033864 . obo:HP_0033869 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the medulla of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T19:09:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cholesterol emboli within the medullary peritubular capillary lumen" ; a owl:Class ; rdfs:label "Medullary peritubular capillary lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033868 . obo:HP_0033870 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the medulla of the kidney." ; dc:date "2021-06-23T19:10:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraluminal thrombi within medullary peritubular capillaries" ; a owl:Class ; rdfs:label "Medullary peritubular capillary intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033868 . obo:HP_0033871 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the medulla of the kidney." ; dc:date "2021-06-23T19:17:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Organised thrombi within the medullary peritubular capillary lumen", "Organized thrombi within the medullary peritubular capillary lumen" ; a owl:Class ; rdfs:label "Medullary peritubular capillary lumen organized thrombi" ; rdfs:subClassOf obo:HP_0033868 . obo:HP_0033872 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the cortex of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T19:22:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical peritubular capillary lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033863 . obo:HP_0033873 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the cortex of the kidney." ; dc:date "2021-06-23T19:23:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraluminal thrombi within cortical peritubular capillaries" ; a owl:Class ; rdfs:label "Cortical peritubular capillary intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033863 . obo:HP_0033874 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the cortex of the kidney." ; dc:date "2021-06-23T19:24:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical peritubular capillary lumen organized thrombi" ; rdfs:subClassOf obo:HP_0033863 . obo:HP_0033875 obo:IAO_0000115 "Abnormal structural characteristics of the interior space (lumen) of the arcuate vein of the kidney." ; dc:date "2021-06-23T19:25:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal arcuate vein lumen morphology" ; rdfs:subClassOf obo:HP_0033853 . obo:HP_0033876 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of arcuate veins of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T19:27:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cholesterol emboli within arcuate vein lumen" ; a owl:Class ; rdfs:label "Arcuate vein lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033875 . obo:HP_0033877 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate veins of the kidney." ; dc:date "2021-06-23T19:29:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraluminal thrombi within arcuate veins" ; a owl:Class ; rdfs:label "Arcuate vein intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033875 . obo:HP_0033878 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate veins of the kidney." ; dc:date "2021-06-23T19:31:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Organised thrombi within arcuate vein lumen", "Organized thrombi within arcuate vein lumen" ; a owl:Class ; rdfs:label "Arcuate vein lumen organized thrombi" ; rdfs:subClassOf obo:HP_0033875 . obo:HP_0033879 obo:IAO_0000115 "Any structural anomaly located in the inner or middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-23T19:33:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal arcuate vein intima/media morphology" ; rdfs:subClassOf obo:HP_0033853 . obo:HP_0033880 obo:IAO_0000115 "Accumulation of edematous extracellular matrix in the inner layer (intima) of arcuate veins of the kidney. The material resembles mucus and appears pale blue on hematoxylin and eosin staining." ; dc:date "2021-06-23T19:35:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intimal mucoid edema within arcuate veins", "Intimal mucoid oedema within arcuate veins" ; a owl:Class ; rdfs:label "Arcuate vein intimal mucoid edema" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033881 obo:IAO_0000115 "Accumulation of myxoid material (mucus-like material) within the inner or middle layer of the arcuate vein of the kidney." ; dc:date "2021-06-23T19:47:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myxomatous change within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate vein intimal/medial myxomatous degeneration" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033882 obo:IAO_0000115 "Amorphous extracellular substance in the inner or middle layer of the arcuate veins of the kidney. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy." ; dc:date "2021-06-23T19:48:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amyloidosis within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate vein intima/medial amyloidosis" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033883 obo:IAO_0000115 "Any structural anomaly of the radial arteries that branch off at right angles from the arcuate artery and carry blood toward the cortex of the kidney." ; dc:date "2021-06-23T19:58:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal interlobular artery morphology" ; a owl:Class ; rdfs:label "Abnormal cortical radial artery morphology" ; rdfs:subClassOf obo:HP_0033836 . obo:HP_0033884 obo:IAO_0000115 "Abnormal structural characteristics of the interior space of the cortical radial arteries of the kidney." ; dc:date "2021-06-23T20:01:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal interlobular arterial lumen morphology" ; a owl:Class ; rdfs:label "Abnormal cortical radial artery lumen morphology" ; rdfs:subClassOf obo:HP_0033883 . obo:HP_0033885 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of cortical radial arteries (interlobular arteries) of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T20:02:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical radial artery lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033884 . obo:HP_0033886 obo:IAO_0000115 "Anomalous structure of the inner or middle layer of the arc-shaped arteries located at the border of the renal cortex and renal medulla." ; dc:date "2021-06-23T20:15:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormalities of the arcuate arterial intima/media" ; a owl:Class ; rdfs:label "Abnormal arcuate artery intima/media morphology" ; rdfs:subClassOf obo:HP_0033837 . obo:HP_0033887 obo:IAO_0000115 "Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy" ; dc:date "2021-06-23T21:57:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amyloidosis within interlobular arterial intima/media", "Interlobular arterial intima/media amyloidosis" ; a owl:Class ; rdfs:label "Cortical radial artery intimal/medial amyloidosis" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033888 obo:IAO_0000115 "Any structural anomaly of the inner or middle layer of the cortical radial arteries (also known as interlobular arteries) of the kidney." ; dc:date "2021-06-23T22:00:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormalities of the interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Abnormal cortical radial artery intima/media morphology" ; rdfs:subClassOf obo:HP_0033883 . obo:HP_0033889 obo:IAO_0000115 "Any structural anomaly of the glomerular arterioles. The interlobar arteries of the kidney branch into arcuate arteries, cortical radiate arteries, and then into afferent arterioles. After passing through the renal corpuscle, the capillaries form the efferent arteriole. The afferent and efferent arterioles are difficult to distinguish histologically and are thus both included in this term and its descendents." ; dc:date "2021-06-23T22:04:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Renal blood flow originates at the hilum of the kidney through the renal artery. From the segmental artery to the interlobar artery, blood arrives parallel to the corticomedullary junction in the arcuate artery. This gives rise to the interlobular arteries that radiate toward the surface. Afferent arterioles branch off which ultimately leads into the glomerulus of Bowman's capsule. From here, efferent arterioles begin to form the venous system and subdivide into another set of capillaries known as the peritubular capillaries. Blood then leaves the kidney and enters the venous circulation. However, efferent arterioles that are located above the corticomedullary border travel downward into the medulla. They further divide into vasa recta which surround the Loop of Henle." ; rdfs:label "Abnormal renal arteriole morphology" ; rdfs:subClassOf obo:HP_0033835 . obo:HP_0033890 obo:IAO_0000115 "Abnormal structural characteristics of the interior space (lumen) of renal arterioles." ; dc:date "2021-06-23T22:09:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal arteriole lumen morphology" ; rdfs:subClassOf obo:HP_0033889 . obo:HP_0033891 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of arterioles of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T22:11:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cholesterol emboli within the arteriolar lumen" ; a owl:Class ; rdfs:label "Renal arteriolar lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033890 . obo:HP_0033892 obo:IAO_0000115 "Any structural anomaly located in the inner or middle layer of the arterioles of the kidney." ; dc:date "2021-06-23T22:13:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal arteriole intima/media morphology" ; rdfs:subClassOf obo:HP_0033889 . obo:HP_0033893 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arterioles of the kidney." ; dc:date "2021-06-23T22:15:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriolar lumen organized thrombi" ; rdfs:subClassOf obo:HP_0033890 . obo:HP_0033894 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arterioles of the kidney." ; dc:date "2021-06-23T22:16:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriolar intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033890 . obo:HP_0033895 obo:IAO_0000115 "Any structural anomaly of the lining (endothelium) of the arterioles of the kidney." ; dc:date "2021-06-23T22:17:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal renal arteriole endothelium morphology" ; rdfs:subClassOf obo:HP_0033889 . obo:HP_0033896 obo:IAO_0000115 "Abnormal structural characteristics of the interior space (lumen) of the arcuate artery of the kidney." ; dc:date "2021-06-23T22:21:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormalities of the arcuate arterial lumen" ; a owl:Class ; rdfs:label "Abnormal arcuate artery lumen morphology" ; rdfs:subClassOf obo:HP_0033837 . obo:HP_0033897 obo:IAO_0000115 "Needle-like or slit-like clefts within the interior space of arcuate arteries of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." ; dc:date "2021-06-23T22:23:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cholesterol emboli within arcuate arterial lumen" ; a owl:Class ; rdfs:label "Arcuate artery lumen cholesterol emboli" ; rdfs:subClassOf obo:HP_0033896 . obo:HP_0033898 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate arteries of the kidney." ; dc:date "2021-06-23T22:25:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraluminal thrombi within arcuate arterial lumen" ; a owl:Class ; rdfs:label "Arcuate artery intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033896 . obo:HP_0033899 obo:IAO_0000115 "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate arteries of the kidney." ; dc:date "2021-06-23T22:26:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Organised thrombi within arcuate arterial lumen", "Organized thrombi within arcuate arterial lumen" ; a owl:Class ; rdfs:label "Arcuate artery lumen organized thrombi" ; rdfs:subClassOf obo:HP_0033896 . obo:HP_0033900 obo:IAO_0000115 "Amorphous extracellular substance in the inner or middle layer of renal arterioles. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy." ; dc:date "2021-06-23T22:28:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amyloidosis within renal arteriolar intima/media" ; a owl:Class ; rdfs:label "Renal arteriole intima/media amyloidosis" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033901 obo:IAO_0000115 "Any structural anomaly of the lining (endothelium) of the arcuate arteries of the kidney." ; dc:date "2021-06-23T22:31:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal arcuate artery endothelium morphology" ; rdfs:subClassOf obo:HP_0033837 . obo:HP_0033902 obo:IAO_0000115 "Enlargement of endothelial cells of the arcuate arteries of the kidney because of cytoplasmic swelling." ; dc:date "2021-06-23T22:35:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endotheliosis within arcuate arteries" ; a owl:Class ; rdfs:label "Arcuate artery endotheliosis" ; rdfs:subClassOf obo:HP_0033901 . obo:HP_0033903 obo:IAO_0000115 "Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the arcuate arteries of the kidney." ; dc:date "2021-06-23T22:37:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arcuate artery" ; a owl:Class ; rdfs:label "Arcuate artery endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033901 . obo:HP_0033904 obo:IAO_0000115 "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material (hyalinosis) in the inner or middle layer of the renal arterioles. This feature may be accompanied by hypertrophy of the media and intima fibrosis." ; dc:date "2021-06-23T22:43:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole intima/media hyalinosis" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033905 obo:IAO_0000115 "Thickening of the intima of the arcuate arteries of the kidney with fibrosis and/or duplication of the elastic lamina." ; dc:date "2021-06-23T22:47:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Arteriosclerosis within arcuate arterial intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media arteriosclerosis" ; rdfs:subClassOf obo:HP_0033886 . obo:HP_0033906 obo:IAO_0000115 "Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural." ; dc:date "2021-06-23T22:50:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal intimal/medial arteriolitis" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033907 obo:IAO_0000115 "Thickening of the intima of renal arterioles with fibrosis and/or duplication of the elastic lamina." ; dc:date "2021-06-23T22:52:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole intima/media arteriolosclerosis" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033908 obo:IAO_0000115 "Atrophy (wasting, decreased thickness) of of the middle layer of the arterioles of the kidney." ; dc:date "2021-06-23T22:55:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole medial atrophy" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033909 obo:IAO_0000115 "Increased thickness of middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-23T23:00:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial hypertrophy within arcuate veins" ; a owl:Class ; rdfs:label "Arcuate vein medial hypertrophy" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033910 obo:IAO_0000115 "Atrophy (wasting, decreased thickness) of the middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-23T23:01:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial atrophy within arcuate veins" ; a owl:Class ; rdfs:label "Arcuate vein medial atrophy" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033911 obo:IAO_0000115 "Increased thickness of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney." ; dc:date "2021-06-23T23:07:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Interlobular artery medial hypertrophy", "Medial hypertrophy within interlobular arteries" ; a owl:Class ; rdfs:label "Cortical radial artery medial hypertrophy" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033912 obo:IAO_0000115 "Atrophy (wasting, decreased thickness) of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney." ; dc:date "2021-06-23T23:09:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Interlobular artery medial atrophy", "Medial atrophy within interlobular arteries" ; a owl:Class ; rdfs:label "Cortical radial artery medial atrophy" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033913 obo:IAO_0000115 "Inflammation of a the intima or the entire wall of cortical radial arteries (also known as the interlobular arteries) of the kidney." ; dc:date "2021-06-23T23:12:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Arteritis within interlobular arterial intima/media", "Interlobular artery medial/intimal arteriitis" ; a owl:Class ; rdfs:label "Cortical radial artery medial/intimal arteriitis" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033914 obo:IAO_0000115 "Amorphous extracellular substance in the inner or middle layer of the arcuate arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy." ; dc:date "2021-06-23T23:14:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amyloidosis within arcuate arterial intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media amyloidosis" ; rdfs:subClassOf obo:HP_0033886 . obo:HP_0033915 obo:IAO_0000115 "Accumulation of edematous extracellular matrix in intima resembling mucus. This feature appears pale blue on hematoxylin and eosin staining." ; dc:date "2021-06-23T23:16:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arcuate artery intimal mucoid edema" ; rdfs:subClassOf obo:HP_0033886 . obo:HP_0033916 obo:IAO_0000115 "Thickening of the intima with fibrosis and/or duplication of the elastic lamina in arcuate veins." ; dc:date "2021-06-23T23:19:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial/intimal arcuate venosclerosis" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033917 obo:IAO_0000115 "Inflammation of arcuate veins of the kidney, which may involve only the intima or can be transmural." ; dc:date "2021-06-23T23:29:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Venulitis within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate intimal/medial venulitis" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033918 obo:IAO_0000115 "Increased thickness of middle layer of the arterioles of the kidney." ; dc:date "2021-06-23T23:31:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial hypertrophy within arterioles" ; a owl:Class ; rdfs:label "Renal arteriole medial hypertrophy" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033919 obo:IAO_0000115 "Inflammation of the inner or middle layer of arcuate venules. This feature may involve only the intima or it can be transmural." ; dc:date "2021-06-24T00:52:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Medial/intimal arcuate venulitis" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033920 obo:IAO_0000115 "Deposition of storage material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arterioles of the kidney." ; dc:date "2021-06-24T00:55:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Accumulated storage material within arteriolar intima/media" ; a owl:Class ; rdfs:label "Renal arteriole intima/media storage material accumulation" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033921 obo:IAO_0000115 "Abnormal and excessive number of cells (hypercellularity) in the lining (endothelium) of the arterioles of the kidney." ; dc:date "2021-06-24T00:57:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arterioles" ; a owl:Class ; rdfs:label "Renal arteriole endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033895 . obo:HP_0033922 obo:IAO_0000115 "A type of renal arteriole endoarterial hypercellularity due to increased number of white blood cells (leukocytes)." ; dc:date "2021-06-24T01:00:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole leukocytic endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033921 . obo:HP_0033923 obo:IAO_0000115 "A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen." ; dc:date "2021-06-24T01:02:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arterioles consisting of foam cells" ; a owl:Class ; rdfs:label "Renal arteriole foam cell endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033922 . obo:HP_0033924 obo:IAO_0000115 "A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased numbers of neutrophils within the arteriolar lumen." ; dc:date "2021-06-24T01:04:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arterioles consisting of neutrophils" ; a owl:Class ; rdfs:label "Renal arteriole neutrophil endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033922 . obo:HP_0033925 obo:IAO_0000115 "A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased number of lymphocytes in the arteriolar lumen." ; dc:date "2021-06-24T01:06:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arterioles consisting of lymphocytes" ; a owl:Class ; rdfs:label "Renal arteriole lymphocyte endoarterial hypercellularity" ; rdfs:subClassOf obo:HP_0033922 . obo:HP_0033926 obo:IAO_0000115 "Myointimal hyperplasia arranged in multiple concentric layers in the inner or middle layer of the arterioles of the kidney." ; dc:date "2021-06-24T01:08:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multilamellation (onion skinning) within renal arteriole intima/media", "Renal arteriole intima/media multilamellation", "Renal arteriole intimal/medial onion skinning" ; a owl:Class ; rdfs:label "Renal arteriole intimal/medial multilamellation" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033927 obo:IAO_0000115 "Arcuate artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes)." ; dc:date "2021-06-24T01:12:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arcuate artery consisting of leukocytes" ; a owl:Class ; rdfs:label "Arcuate artery endoarterial leukocyte hypercellularity" ; rdfs:subClassOf obo:HP_0033903 . obo:HP_0033928 obo:IAO_0000115 "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen." ; dc:date "2021-06-24T01:13:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arcuate artery consisting of foam cells" ; a owl:Class ; rdfs:label "Arcuate artery endoarterial foam cell hypercellularity" ; rdfs:subClassOf obo:HP_0033927 . obo:HP_0033929 obo:IAO_0000115 "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils withinin the lumen of arcuate artery." ; dc:date "2021-06-24T01:14:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arcuate artery consisting of neutrophils" ; a owl:Class ; rdfs:label "Arcuate artery endoarterial neutrophil hypercellularity" ; rdfs:subClassOf obo:HP_0033927 . obo:HP_0033930 obo:IAO_0000115 "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of arcuate artery." ; dc:date "2021-06-24T01:16:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within arcuate artery consisting of lymphocytes" ; a owl:Class ; rdfs:label "Arcuate artery endoarterial lymphocyte hypercellularity" ; rdfs:subClassOf obo:HP_0033927 . obo:HP_0033931 obo:IAO_0000115 "Death of tissue in the inner or middle layer of the arcuate artery of the kidney." ; dc:date "2021-06-24T01:19:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arcuate artery intima/media necrosis" ; rdfs:subClassOf obo:HP_0033886 . obo:HP_0033932 obo:IAO_0000115 "A type of arcuate artery intima/media necrosis in which the necrotic tissue retains the outlines of the dead (necrotic) structures." ; dc:date "2021-06-24T01:20:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coagulative necrosis within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media coagulative necrosis" ; rdfs:subClassOf obo:HP_0033931 . obo:HP_0033933 obo:IAO_0000115 "A type of arcuate artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." ; dc:date "2021-06-24T01:22:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liquefactive necrosis of the arcuate artery intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media liquefactive necrosis" ; rdfs:subClassOf obo:HP_0033931 . obo:HP_0033934 obo:IAO_0000115 "Accumulation of material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-24T01:25:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multilamellation (onion skinning) within arteriolar intima/media", "Renal arteriole intima/media onion skinning" ; a owl:Class ; rdfs:label "Arcuate vein intimal/medial storage material accumulation" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033935 obo:IAO_0000115 "Cell death (necrosis) in the inner or middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney." ; dc:date "2021-06-24T01:36:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Necrosis within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Cortical radial artery intima/media necrosis" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033936 obo:IAO_0000115 "A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." ; dc:date "2021-06-24T01:39:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liquefactive necrosis within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Cortical radial artery intima/media liquefactive necrosis" ; rdfs:subClassOf obo:HP_0033935 . obo:HP_0033937 obo:IAO_0000115 "A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." ; dc:date "2021-06-24T01:41:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical radial artery intima/media coagulative necrosis" ; rdfs:subClassOf obo:HP_0033935 . obo:HP_0033938 obo:IAO_0000115 "Cell death (necrosis) in the inner or middle layer of the arterioles of the kidney." ; dc:date "2021-06-24T01:43:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole intima/media necrosis" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033939 obo:IAO_0000115 "A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." ; dc:date "2021-06-24T01:44:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liquefactive necrosis of the renal arteriolar intima/media" ; a owl:Class ; rdfs:label "Renal arteriole intima/media liquefactive necrosis" ; rdfs:subClassOf obo:HP_0033938 . obo:HP_0033940 obo:IAO_0000115 "A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." ; dc:date "2021-06-24T01:45:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal arteriole intima/media coagulative necrosis" ; rdfs:subClassOf obo:HP_0033938 . obo:HP_0033941 obo:IAO_0000115 "A type of renal intimal/medial arteriolitis characteriezed by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries." ; dc:date "2021-06-24T01:48:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Granulomatous arteriolitis within arteriolar intima/media" ; a owl:Class ; rdfs:label "Granulomatous arteriolitis of the arteriolar intima/media" ; rdfs:subClassOf obo:HP_0033906 . obo:HP_0033942 obo:IAO_0000115 "Cell death (necrosis) of the inner or middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-24T01:51:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Necrosis within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate vein medial/intimal necrosis" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033943 obo:IAO_0000115 "A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." ; dc:date "2021-06-24T01:52:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coagulative necrosis within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate vein medial/intimal coagulative necrosis" ; rdfs:subClassOf obo:HP_0033942 . obo:HP_0033944 obo:IAO_0000115 "A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." ; dc:date "2021-06-24T01:53:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liquefactive necrosis within arcuate vein intima/media" ; a owl:Class ; rdfs:label "Arcuate vein medial/intimal liquefactive necrosis" ; rdfs:subClassOf obo:HP_0033942 . obo:HP_0033945 obo:IAO_0000115 "A type of arcuate intimal/medial venulitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins." ; dc:date "2021-06-24T01:56:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arcuate intimal/medial granulomatous venulitis" ; rdfs:subClassOf obo:HP_0033917 . obo:HP_0033946 obo:IAO_0000115 "Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arcuate veins of the kidney." ; dc:date "2021-06-24T01:57:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arcuate vein intima/media crystal accumulation" ; rdfs:subClassOf obo:HP_0033879 . obo:HP_0033947 obo:IAO_0000115 "Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arterioles of the kidney." ; dc:date "2021-06-24T01:59:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Accumulated crystals within renal arteriolar intima/media" ; a owl:Class ; rdfs:label "Renal arteriole intima/media crystal accumulation" ; rdfs:subClassOf obo:HP_0033892 . obo:HP_0033948 obo:IAO_0000115 "Inflammation of the inner or middle layer of the arcuate arteries of the kidney." ; dc:date "2021-06-24T12:14:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Arteritis within arcuate arterial intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media arteriitis" ; rdfs:subClassOf obo:HP_0033886 . obo:HP_0033949 obo:IAO_0000115 "A type of arcuate artery intima/media granulomatous arteriitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries." ; dc:date "2021-06-24T12:16:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Granulomatous arteritis within arcuate arterial intima/media" ; a owl:Class ; rdfs:label "Arcuate artery intima/media granulomatous arteriitis" ; rdfs:subClassOf obo:HP_0033948 . obo:HP_0033950 obo:IAO_0000115 "Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen within the interior space of cortical radial arteries (interlobular arteries) of the kidney." ; dc:date "2021-06-24T12:18:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraluminal thrombi within interlobular arterial lumen" ; a owl:Class ; rdfs:label "Cortical radial artery intraluminal thrombi" ; rdfs:subClassOf obo:HP_0033884 . obo:HP_0033951 obo:IAO_0000115 "Thrombi containing fibrous tissue and capillary-like vascular channels within the interior space of cortical radial arteries (interlobular arteries) of the kidney." ; dc:date "2021-06-24T12:19:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Organised thrombi within interlobular arterial lumen", "Organized thrombi within interlobular arterial lumen" ; a owl:Class ; rdfs:label "Cortical radial artery intraluminal organized thrombi" ; rdfs:subClassOf obo:HP_0033950 . obo:HP_0033952 obo:IAO_0000115 "Abnormal structural characteristics of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney." ; dc:date "2021-06-24T12:21:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormalities of the interlobular arterial endothelium" ; a owl:Class ; rdfs:label "Abnormal cortical radial artery endothelium morphology" ; rdfs:subClassOf obo:HP_0033883 . obo:HP_0033953 obo:IAO_0000115 "Enlargement of endothelial cells of the cortical radial arteries (also known as the interlobular arteries) of the kidney because of cytoplasmic swelling." ; dc:date "2021-06-24T12:24:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endotheliosis within interlobular arteries" ; a owl:Class ; rdfs:label "Cortical radial artery endotheliosis" ; rdfs:subClassOf obo:HP_0033952 . obo:HP_0033954 obo:IAO_0000115 "Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney." ; dc:date "2021-06-24T12:26:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within interlobular artery" ; a owl:Class ; rdfs:label "Cortical radial artery hypercellularity" ; rdfs:subClassOf obo:HP_0033952 . obo:HP_0033955 obo:IAO_0000115 "A type of cortical radial artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes)." ; dc:date "2021-06-24T12:28:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within interlobular artery consisting of leukocytes" ; a owl:Class ; rdfs:label "Cortical radial artery leukocyte hypercellularity" ; rdfs:subClassOf obo:HP_0033954 . obo:HP_0033956 obo:IAO_0000115 "A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of cortical radial arteries." ; dc:date "2021-06-24T12:29:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endoarterial hypercellularity within interlobular artery consisting of lymphocytes" ; a owl:Class ; rdfs:label "Cortical radial artery lymphocyte hypercellularity" ; rdfs:subClassOf obo:HP_0033955 . obo:HP_0033957 obo:IAO_0000115 "A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils in the lumen of cortical radial arteries." ; dc:date "2021-06-24T12:30:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endocapillary hypercellularity within interlobular arterial endothelium consisting of neutrophils" ; a owl:Class ; rdfs:label "Cortical radial artery neutrophil hypercellularity" ; rdfs:subClassOf obo:HP_0033955 . obo:HP_0033958 obo:IAO_0000115 "A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often macrophages, with a vacuolated appearance in the lumen of cortical radial artery (also known as the interlobular artery) of the kidney." ; dc:date "2021-06-24T12:31:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Endocapillary hypercellularity within interlobular arterial endothelium consisting of foam cells" ; a owl:Class ; rdfs:label "Cortical radial artery foam cell hypercellularity" ; rdfs:subClassOf obo:HP_0033955 . obo:HP_0033959 obo:IAO_0000115 "Thickening of the intima of the cortical radial artery (also known as the interlobular artery) of the kidney characterized by fibrosis and/or duplication of the elastic lamina." ; dc:date "2021-06-24T12:33:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Arteriosclerosis within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Cortical radial artery intima/media arteriosclerosis" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033960 obo:IAO_0000115 "Accumulation of edematous extracellular matrix in the intima of the cortical radial artery (also known as the interlobular artery) of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining." ; dc:date "2021-06-24T12:35:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intimal mucoid edema within interlobular arterial intima/media", "Intimal mucoid oedema within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Cortical radial artery intimal mucoid edema" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033961 obo:IAO_0000115 "Myointimal hyperplasia of the inner and middle layer of the cortical radial artery (also known as the interlobular artery) of the kidney, arranged in multiple concentric layers." ; dc:date "2021-06-24T12:38:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cortical radial artery intima/media onion skinning", "Multilamellation (onion skinning) within interlobular arterial intima/media" ; a owl:Class ; rdfs:label "Cortical radial artery intima/media multilamellation" ; rdfs:subClassOf obo:HP_0033888 . obo:HP_0033962 obo:IAO_0000115 "A type of cortical radial artery medial/intimal arteriitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries." ; dc:date "2021-06-24T12:39:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cortical radial artery medial/intimal granulomatous arteriitis" ; rdfs:subClassOf obo:HP_0033913 . obo:HP_0033963 obo:IAO_0000115 "Any structural anomaly of the inner or middle layer of the interlobular veins of the kidney." ; dc:date "2021-06-24T12:45:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal interlobular vein intima/media morphology" ; rdfs:subClassOf obo:HP_0033854 . obo:HP_0033964 obo:IAO_0000115 "Thickening of the intima with fibrosis and/or duplication of the elastic lamina in interlobular veins of the kidney." ; dc:date "2021-06-24T12:46:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Venosclerosis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular intima/media venosclerosis" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033965 obo:IAO_0000115 "Accumulation of edematous extracellular matrix in the intima of the interlobular vein of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining." ; dc:date "2021-06-24T12:47:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intimal mucoid edema within interlobular veins", "Intimal mucoid oedema within interlobular veins" ; a owl:Class ; rdfs:label "Interlobular vein intimal mucoid edema" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033966 obo:IAO_0000115 "Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular veins of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy" ; dc:date "2021-06-24T12:49:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Amyloidosis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media amyloidosis" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033967 obo:IAO_0000115 "Inflammation of the interlobular veins of the kidney which may affect only the intima or may be transmural." ; dc:date "2021-06-24T12:51:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Venulitis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media venulitis" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033968 obo:IAO_0000115 "A type of interlobular vein intima/media venulitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins." ; dc:date "2021-06-24T12:52:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Granulomatous venulitis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media granulomatous venulitis" ; rdfs:subClassOf obo:HP_0033967 . obo:HP_0033969 obo:IAO_0000115 "Cell death (necrosis) in the inner or middle layer of the interlobular vein of the kidney." ; dc:date "2021-06-24T12:53:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Necrosis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media necrosis" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033970 obo:IAO_0000115 "A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." ; dc:date "2021-06-24T12:54:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liquefactive necrosis within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media liquefactive necrosis" ; rdfs:subClassOf obo:HP_0033969 . obo:HP_0033971 obo:IAO_0000115 "A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." ; dc:date "2021-06-24T12:56:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interlobular vein intima/media coagulative necrosis" ; rdfs:subClassOf obo:HP_0033969 . obo:HP_0033972 obo:IAO_0000115 "Atrophy (wasting, decreased thickness) of the medial layer pf the interlobular veins of the kidney." ; dc:date "2021-06-24T12:57:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial atrophy within interlobular veins" ; a owl:Class ; rdfs:label "Interlobular vein medial atrophy" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033973 obo:IAO_0000115 "Increased thickness of middle layer of the interlobular veins of the kidney." ; dc:date "2021-06-24T12:58:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial hypertrophy within interlobular veins" ; a owl:Class ; rdfs:label "Interlobular vein medial hypertrophy" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033974 obo:IAO_0000115 "Myointimal hyperplasia of the inner and middle layer of the interlobular veins of the kidney, arranged in multiple concentric layers." ; dc:date "2021-06-24T14:07:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Interlobular vein intima/media onion skinning", "Multilamellation (onion skinning) within interlobular vein intima/media" ; a owl:Class ; rdfs:label "Interlobular vein intima/media multilamellation" ; rdfs:subClassOf obo:HP_0033963 . obo:HP_0033975 obo:IAO_0000115 "Absence of the fingernail of the index (second) finger." ; dc:date "2021-06-25T13:58:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent second fingernail" ; rdfs:subClassOf obo:HP_0001817 . obo:HP_0033976 obo:IAO_0000115 "The presence of an extra nail on the palmar (volar, ventral) surface of the finger." ; dc:date "2021-06-25T14:01:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Palmar fingernail", "Ventral fingernail" ; a owl:Class ; rdfs:label "Volar fingernail" ; rdfs:subClassOf obo:HP_0001231 . obo:HP_0033977 obo:IAO_0000115 "Absent talus owing to a congenital defect." ; dc:date "2021-06-25T14:07:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent talus", "Talus aplasia" ; a owl:Class ; rdfs:label "Talar aplasia" ; rdfs:subClassOf obo:HP_0008365 . obo:HP_0033978 obo:IAO_0000115 "Diminished activity of the enzyme beta-hexosaminidase in the blood circulation." ; dc:date "2021-06-25T14:10:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hexosaminidase B low in blood" ; a owl:Class ; rdfs:label "Reduced beta-hexosaminidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0033979 obo:IAO_0000115 "Excessive anterior displacement of the tracheal and/or bronchial membranous wall." ; dc:date "2021-07-15T11:33:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Membranous tracheobronchomalacia" ; a owl:Class ; rdfs:label "Excessive dynamic airway collapse" ; rdfs:subClassOf obo:HP_0002786 . obo:HP_0033980 obo:IAO_0000115 "Recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness." ; dc:date "2021-07-15T11:36:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paroxysmal tonic upgaze" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0033981 obo:IAO_0000115 "Abnormal tortuous (i.e., twisted) form of the vertebral arteries." ; dc:date "2021-07-15T11:39:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tortuous vertebral arteries" ; a owl:Class ; rdfs:label "Vertebral artery tortuosity" ; rdfs:subClassOf obo:HP_0005116, obo:HP_0030321 . obo:HP_0033982 obo:IAO_0000115 "A separation (dissection) of the layers of the celiac artery wall." ; dc:date "2021-07-15T11:41:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Celiac artery dissection" ; rdfs:subClassOf obo:HP_0012326 . obo:HP_0033983 obo:IAO_0000115 "Reduced concentration of apolipoprotein C-II in the blood circulation." ; dc:date "2021-07-15T11:42:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased plasma apolipoprotein C-II" ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein C-II concentration" ; rdfs:subClassOf obo:HP_0033459 . obo:HP_0033984 obo:IAO_0000115 "An elevated amount of 8-oxo-7,8-dihydroguanosine in the urine." ; dc:date "2021-07-15T11:47:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urinary 8-oxo-7,8-dihydroguanosine", "Increased urinary 8-oxo-Gsn level", "Increased urine 8-oxo-7,8-dihydroguanosine", "Increased urine 8-oxo-GMP" ; a owl:Class ; rdfs:label "Increased urinary 8-oxo-7,8-dihydroguanosine level" ; rdfs:subClassOf obo:HP_0033161 . obo:HP_0033985 obo:IAO_0000115 "Increased length of the neck of the femur." ; dc:date "2021-07-15T11:54:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Long femoral neck" ; a owl:Class ; rdfs:label "Elongated femoral neck" ; rdfs:subClassOf obo:HP_0003367 . obo:HP_0033986 obo:IAO_0000115 "The presence of an increased number of twists and turns of lymphatic vessels." ; dc:date "2021-07-15T11:55:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tortuous lymphatics" ; a owl:Class ; rdfs:comment "This feature can be ascertained by near-infrared fluorescence lymphatic imaging." ; rdfs:label "Tortuous lymphatic vessels" ; rdfs:subClassOf obo:HP_0100766 . obo:HP_0033987 obo:IAO_0000115 "A rare, endocrine active tumor that causes severe renal phosphate wasting, which in turn can lead to critical osteomalacia. Phosphaturic mesenchymal tumors (PMTs) are typically small and mostly benign tumors producing fibroblast growth factor 23 (FGF-23). FGF-23 lowers the expression of sodium/phosphate cotransporters, which are the primary transport proteins responsible for phosphate reabsorption in the kidneys. The paraneoplastic overproduction of FGF-23 lowers reabsorption of phosphate and causes severe paraneoplastic renal phosphate wasting and hypophosphatemia. FGF-23 also affects vitamin D levels by lowering 25-hydroxyvitamin D 1-alpha-hydroxylase in the proximal renal tubules and by increasing the expression of vitamin D 24-hydroxylase, a mitochondrial enzyme responsible for inactivating vitamin D metabolites." ; dc:date "2021-07-15T12:04:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Phosphaturic mesenchymal tumor" ; rdfs:subClassOf obo:HP_0031459 . obo:HP_0033988 obo:IAO_0000115 "An infarct located in the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe that can only be observed microscopically." ; dc:date "2021-08-18T12:10:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Amygdala microinfarct" ; rdfs:subClassOf obo:HP_0033668 . obo:HP_0033989 obo:IAO_0000115 "An infarct located in the structure of the cerebrum involved with memory storage and spatial navigation that can only be observed microscopically." ; dc:date "2021-08-18T12:19:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hippocampal microinfarct" ; rdfs:subClassOf obo:HP_0025100 . obo:HP_0033990 obo:IAO_0000115 "Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness." ; dc:date "2021-08-18T12:24:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cartilaginous malacia" ; a owl:Class ; rdfs:comment "This term is to be distinguihsed from its sibling Excessive dynamic airway collapse, which refers to excessive anterior displacement of the membranous wall of the trachea." ; rdfs:label "Cartilaginous tracheobronchomalacia" ; rdfs:subClassOf obo:HP_0002786 . obo:HP_0033991 obo:IAO_0000115 "Vasa previa occurs when the membranes that contain the umbilical cord traverse the membranes overlying the internal os of the cervix. There is a high risk of fetal mortality if not identified perinatally." ; dc:date "2021-08-18T12:29:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This abnormality is problematic because of the location of the unprotected vessels. If the fetal head compresses these vessels, it can result in fetal hypoperfusion and acidemia. If the vessels rupture it can lead to fetal hemorrhage." ; rdfs:label "Vasa previa" ; rdfs:subClassOf obo:HP_0011418 . obo:HP_0033992 obo:IAO_0000115 "Inability of the heart to increase its rate commensurate with increased activity or demand." ; dc:date "2021-08-20T13:16:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Chronotropic incompetence is common in patients with cardiovascular disease, produces exercise intolerance that impairs quality of life, and is an independent predictor of major adverse cardiovascular events and overall mortality." ; rdfs:label "Chronotropic incompetence" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0033993 obo:IAO_0000115 "An inflammation of brain parenchyma due to infection with a virus. Viral encephalitis can occur as a rare complication of common infections (eg, herpes virus infections) or can occur as a characteristic presentation of rare viruses (eg, rabies virus infection). Encephalitis may be the only neurologic manifestation of infection, or may occur in association with meningitis, myelitis, radiculitis, or neuritis. Viral encephalitis is associated with neurological dysfunction." ; dc:date "2021-08-21T11:43:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Severe viral infections including viral encephalitis may occur in individuals with underlying mmunodeficiencies." ; rdfs:label "Viral encephalitis" ; rdfs:subClassOf obo:HP_0002383, obo:HP_0032169 . obo:HP_0033994 obo:IAO_0000115 "Inability to ingest sufficient quantities of nutrition by mouth or by tube-feeding with the corresponding requirement for intravenous administration of nutrition." ; dc:date "2021-08-21T12:07:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dependency on parenteral nutrition" ; rdfs:subClassOf obo:HP_0011968 . obo:HP_0033995 obo:IAO_0000115 "The presence of vacuoles bearing centripetal microvilli in small gut villus enterocytes." ; dc:date "2021-08-21T13:07:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See figure 1 of PMID:26830108." ; rdfs:label "Microvillus inclusions" ; rdfs:subClassOf obo:HP_0011472 . obo:HP_0033996 obo:IAO_0000115 "The presenceaccumulationof periodic acid-Schiff (PAS) granules in the subapical region of small intenstinal microvilli, appearing as different kinds of vesicular/tubular structures." ; dc:date "2021-08-21T13:12:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See figure 1 of PMID:26830108." ; rdfs:label "Microvillar PAS-positive secretory granules" ; rdfs:subClassOf obo:HP_0011472 . obo:HP_0033997 obo:IAO_0000115 "Formation of vacuoles, i.e., membrane-bound organelles, in the portion of the cytoplasm near the nucleus within myocytes of the heart." ; dc:date "2021-08-21T14:08:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perinuclear cardiomyocyte vacuolization" ; rdfs:subClassOf obo:HP_0031331 . obo:HP_0033998 obo:IAO_0000115 "A developmental defect of pulmonary lobation characterized by the presence of only one lobe of the right lung, which normally has three lobes." ; dc:date "2021-08-21T14:11:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Single-lobed right lung" ; rdfs:subClassOf obo:HP_0002101 . obo:HP_0033999 obo:IAO_0000115 "Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy." ; dc:date "2021-08-21T14:20:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bronchial bleeding" ; a owl:Class ; rdfs:label "Bronchial hemorrhage" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0034000 obo:IAO_0000115 "Tracheal hemorrhage is a focal bleeding within the trachea. It be diagnosed by tracheobronchoscopy." ; dc:date "2021-08-21T14:33:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tracheal bleeding" ; a owl:Class ; rdfs:label "Tracheal hemorrhage" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0034001 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against complement factor H." ; dc:date "2021-08-21T14:41:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CFH autoantibodies" ; a owl:Class ; rdfs:label "Anti-Complement factor H antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034002 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the phospholipase A2 receptor." ; dc:date "2021-08-21T14:45:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PLA2R antibody positivity" ; a owl:Class ; rdfs:label "Anti-phospholipase A2 receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034003 obo:IAO_0000115 "Regional increase in the width (height) of the middle portion of the eyebrow." ; dc:date "2021-08-22T12:13:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Medial broadening of eyebrows" ; a owl:Class ; rdfs:label "Broad medial eyebrow" ; rdfs:subClassOf obo:HP_0011229 . obo:HP_0034004 obo:IAO_0000115 "Misperception of existing odor, that is, distorted or altered olfactory perception in the presence of known stimuli." ; dc:date "2021-08-22T14:50:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Parosmia should be distinguished from anosmia (lack of sense of smell), hyposmia (reduced sense of smell), and phantosmia (olfactory perception without a stimulus)." ; rdfs:label "Parosmia" ; rdfs:subClassOf obo:HP_0004408 . obo:HP_0034005 obo:IAO_0000115 "An abnormal reduction in the amount of spines on a given dendrite." ; dc:date "2021-08-22T15:18:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A dendritic spine (or spine) is a small membranous protrusion from a neuron's dendrite that typically receives input from a single axon at the synapse. Dendrites are tree-like membrane-bound structures that project from neurons and receive inputs from other neurons." ; rdfs:label "Decreased dendritic spine number" ; rdfs:subClassOf obo:HP_0500032 . obo:HP_0034006 obo:IAO_0000115 "A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation." ; dc:date "2021-08-22T16:26:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0034007 obo:IAO_0000115 "The presence of atrophy (wasting) of the posterior portion of the corpus callosum." ; dc:date "2021-08-22T17:54:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Posterior atrophy of corpus callosum" ; rdfs:subClassOf obo:HP_0033725 . obo:HP_0034008 obo:IAO_0000115 "Wasting (atrophy) of the optic chiasm." ; dc:date "2021-08-22T17:57:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Opto-chiasmatic atrophy" ; rdfs:subClassOf obo:HP_0025163 . obo:HP_0034009 obo:IAO_0000115 "Overgrowth of fat in the perivesical and perirectal area." ; dc:date "2021-08-22T21:26:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pelvic lipomatosis" ; rdfs:subClassOf obo:HP_0001012 . obo:HP_0034010 obo:IAO_0000115 "Increased numbers of megakryocyte precursors (megakaryocyte colony forming units) in the bone marrow." ; dc:date "2021-08-27T18:00:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased megakaryocyte colony forming unit count" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0034011 obo:IAO_0000115 "A reduced proportion of sperm that move in a straight line or large circles; alternatively, an increaed proportion of sperm that move in tight circles or in some other non-linear fashion." ; dc:date "2021-09-04T11:47:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Non-progressive sperm motility" ; a owl:Class ; rdfs:label "Reduced progressive sperm motility" ; rdfs:subClassOf obo:HP_0012206 . obo:HP_0034012 obo:IAO_0000115 "Decreased sweating on the palms and soles." ; dc:date "2021-09-23T11:37:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palmoplantar hypohidrosis" ; rdfs:subClassOf obo:HP_0000966 . obo:HP_0034013 obo:IAO_0000115 "A type of pericallosal lipoma that is thin and curves around the posterior end of the splenium of the corpus callosum." ; dc:date "2021-09-04T14:49:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Curvilinear pericallosal lipoma" ; rdfs:subClassOf obo:HP_0006931 . obo:HP_0034014 obo:IAO_0000115 "A type of pericallosal lipoma with a rounded or lobular appearance and a diameter that is usually above 2 cm. They are anteriorly situated and are associated with extensive callosal and often fronto-facial anomalies. A tubulonodular pericallosal lipoma can extend into the choroid plexus or lateral ventricles." ; dc:date "2021-09-04T14:51:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tubulonodular pericallosal lipoma" ; rdfs:subClassOf obo:HP_0006931 . obo:HP_0034015 obo:IAO_0000115 "Thick-walled abnormal gas-filled interstitial nodule within a lung." ; dc:date "2021-09-04T14:54:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cavitating pulmonary nodule" ; rdfs:subClassOf obo:HP_0033655 . obo:HP_0034016 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen (HLA)." ; dc:date "2021-09-04T15:08:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-human leukocyte antigen antibody positivity" ; a owl:Class ; rdfs:comment "The human major histocompatibility complex is a family of genes that encodes HLAs, which have a crucial role in defence against foreign pathogens and immune surveillance of tumors. HLA molecules are highly polymorphic antigens; antibodies against these antigens can develop as a result of pregnancy, transplantation or blood transfusion." ; rdfs:label "Anti-HLA antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034017 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class I human leukocyte antigen (HLA). Class I HLA corresponds to MHC class I (A, B, and C)." ; dc:date "2021-09-04T15:17:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-class I HLA antibody positivity" ; rdfs:subClassOf obo:HP_0034016 . obo:HP_0034018 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class II human leukocyte antigen (HLA). Class I HLA corresponds to MHC class II (DP, DM, DO, DQ, and DR)." ; dc:date "2021-09-04T15:21:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-class II HLA antibody positivity" ; rdfs:subClassOf obo:HP_0034016 . obo:HP_0034019 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-A (HLA-A)." ; dc:date "2021-09-04T15:22:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-A antibody positivity" ; rdfs:subClassOf obo:HP_0034017 . obo:HP_0034020 obo:IAO_0000115 "The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A)." ; dc:date "2021-09-04T15:24:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-A IgG1 antibody positivity" ; rdfs:subClassOf obo:HP_0034019 . obo:HP_0034021 obo:IAO_0000115 "The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A)." ; dc:date "2021-09-04T15:25:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-A IgG3 antibody positivity" ; rdfs:subClassOf obo:HP_0034019 . obo:HP_0034022 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-B (HLA-B)." ; dc:date "2021-09-04T15:26:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-B antibody positivity" ; rdfs:subClassOf obo:HP_0034017 . obo:HP_0034023 obo:IAO_0000115 "The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B)." ; dc:date "2021-09-04T15:27:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-B IgG1 antibody positivity" ; rdfs:subClassOf obo:HP_0034022 . obo:HP_0034024 obo:IAO_0000115 "The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B)." ; dc:date "2021-09-04T15:27:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-HLA-B IgG3 antibody positivity" ; rdfs:subClassOf obo:HP_0034022 . obo:HP_0034025 obo:IAO_0000115 "Any deviation from the normal concentration of gamma-aminobutyric acid (GABA) in the blood circulation." ; dc:date "2021-09-04T15:32:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating GABA concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034026 obo:IAO_0000115 "An increased concentration of saccharopine in the blood circulation. L-saccharopine is the N(6)-(1,3-dicarboxypropan-1-yl) derivative of L-lysine." ; dc:date "2021-09-04T16:30:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating sacchoropine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034027 obo:IAO_0000115 "Any deviation from the normal amount in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." ; dc:date "2021-09-04T16:34:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary non-proteinogenic amino acid level" ; rdfs:subClassOf obo:HP_0003355 . obo:HP_0034028 obo:IAO_0000115 "Presence of saccharopine in the urine." ; dc:date "2021-09-04T16:35:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Saccharopinuria" ; rdfs:subClassOf obo:HP_0034027 . obo:HP_0034029 obo:IAO_0000115 "The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the liver." ; dc:date "2021-09-24T12:01:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hepatic foam cells" ; rdfs:subClassOf obo:HP_0003651 . obo:HP_0034030 obo:IAO_0000115 "Bluish discoloration of the lips." ; dc:date "2021-09-24T13:02:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bluish lips", "Cyanotic lips", "Labial cyanosis" ; a owl:Class ; rdfs:label "Lip cyanosis" ; rdfs:subClassOf obo:HP_0034031 . obo:HP_0034031 obo:IAO_0000115 "Bluish discoloration of one or more regions of the face." ; dc:date "2021-09-24T13:04:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bluish face", "Cyanotic face" ; a owl:Class ; rdfs:label "Facial cyanosis" ; rdfs:subClassOf obo:HP_0034033 . obo:HP_0034032 obo:IAO_0000115 "Generalized bluish discoloration of the body and the visible mucous membranes, which occurs due to inadequate oxygenation secondary to conditions that lead to an increase in deoxygenated hemoglobin or presence of abnormal hemoglobin." ; dc:date "2021-09-24T13:34:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Central cyanosis" ; rdfs:subClassOf obo:HP_0000961 . obo:HP_0034033 obo:IAO_0000115 "Bluish discoloration of the distal extremities (hands, fingertips, toes), and can sometimes involve circumoral and periorbital areas. Mucous membranes are generally not involved." ; dc:date "2021-09-24T13:36:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peripheral cyanosis" ; rdfs:subClassOf obo:HP_0000961 . obo:HP_0034034 obo:IAO_0000115 "Differential degree of bluish discoloration between the upper and lower extremities." ; dc:date "2021-09-24T13:37:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Differential cyanosis" ; rdfs:subClassOf obo:HP_0000961 . obo:HP_0034035 obo:IAO_0000115 "Fluid exuded from the posterior wall of the pharynx." ; dc:date "2021-09-24T13:44:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fluid from the pharynx", "Pharyngeal fluid" ; a owl:Class ; rdfs:label "Pharyngeal exudate" ; rdfs:subClassOf obo:HP_0033151 . obo:HP_0034036 obo:IAO_0000115 "Inflammatory chilblain-like nodules on the feet and/or toes." ; dc:date "2021-09-24T13:48:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "COVID toe", "Chilblain-like toe lesions", "Chilblain-like toes" ; a owl:Class ; rdfs:label "Pseudo-chilblains on toes" ; rdfs:subClassOf obo:HP_0033696 . obo:HP_0034037 obo:IAO_0000115 "Inflammatory chilblain-like nodules on the hands and/or fingers." ; dc:date "2021-09-24T13:50:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "COVID finger", "COVID fingers" ; a owl:Class ; rdfs:label "Pseudo-chilblains on fingers" ; rdfs:subClassOf obo:HP_0033696 . obo:HP_0034038 obo:IAO_0000115 "Abnormally low blood oxygen level without the presence of dyspnea." ; dc:date "2021-09-24T14:01:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Silent hypoxemia" ; rdfs:subClassOf obo:HP_0012418 . obo:HP_0034039 obo:IAO_0000115 "Two consecutive premature ventricular contractions (PVCs) with no intervening normal beats." ; dc:date "2021-09-25T11:58:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Doublet premature ventricular contractions" ; a owl:Class ; rdfs:label "Ventricular couplet" ; rdfs:subClassOf obo:HP_0034041 . obo:HP_0034040 obo:IAO_0000115 "Bidirectional ventricular tachycardia (BDVT) is a regular ventricular tachyarrhythmia (VT) with two different QRS morphologies alternating at a rate typically between 140 and 180 bpm." ; dc:date "2021-09-25T12:28:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bidirectional ventricular tachycardia" ; rdfs:subClassOf obo:HP_0004756 . obo:HP_0034041 obo:IAO_0000115 "Ventricular ectopics, also known as ventricular extrasystoles, premature ventricular contractions or complexes (PVC) and ventricular premature depolarisations (VPD) are beats arising from within the ventricles. When they occur in groupings such as bigeminy, trigeminy, couplets and triplets they are referred to as ventricular ectopy." ; dc:date "2021-09-25T12:29:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ventricular ectopy" ; rdfs:subClassOf obo:HP_0006682 . obo:HP_0034042 obo:IAO_0000115 "Abnormally increased hair growth in the lskin of the back." ; dc:date "2021-10-02T12:18:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dorsal hirsutism" ; rdfs:subClassOf obo:HP_0009889 . obo:HP_0034043 obo:IAO_0000115 "Elevated amount of bile acids in the feces." ; dc:date "2021-10-15T13:54:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bile acids are synthesized from cholesterol in the liver and have major roles in the absorption of lipids in the small intestine. After their involvement in micelle formation in the small intestine, they are usually effectively reabsorbed in the terminal ileum, and efficiently (over 95%) reabsorbed by the liver from the portal venous blood, and resecreted." ; rdfs:label "Increased fecal bile acid" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034044 obo:IAO_0000115 "Spurs at the medial and lateral acetabular margin and in the center of the acetabulum gives rise to shape resembling a three-pronged spear known as trident." ; dc:date "2021-10-15T14:26:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trident sign" ; a owl:Class ; rdfs:comment "This sign is seen in achondroplasia, Jeune's asphyxiating thoracic dystrophy, Ellis-van Creveld syndrome, and thanatophoric dysplasia. See Figures 2 and 4A in PMID:28744080." ; rdfs:label "Trident pelvis" ; rdfs:subClassOf obo:HP_0001384 . obo:HP_0034045 obo:IAO_0000115 "Normal muscle fibers are polygonal-shaped in cross section, are multinucleated, and have minimal amounts of endomysial connective tissue. In contrast, angulated (also known as angular) muscle fibers have long and narrow vertices (corners) with sharp edges and a pointed tip." ; dc:date "2021-10-19T16:38:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Angular muscle fibers", "Angular muscle fibres" ; a owl:Class ; rdfs:comment "Muscle fibers showing neurogenic atrophy are compressed by neighboring non-atrophic fibers and may show an angulated appearance on a transverse section. See Figure 3A in PMID:32529201." ; rdfs:label "Angulated muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0034046 obo:IAO_0000115 "Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to the mandible." ; dc:date "2021-10-19T16:42:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mandibular osteolysis" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0002797 . obo:HP_0034047 obo:IAO_0000115 "Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to a rib." ; dc:date "2021-10-19T16:45:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rib osteolysis" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0002797 . obo:HP_0034048 obo:IAO_0000115 "A reduced concentration of chenodeoxycholic acid in the blood circulation." ; dc:date "2021-10-19T16:49:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating chenodiol concentration" ; a owl:Class ; rdfs:comment "Chenodeoxycholic acid (chenodiol) is a primary bile acid, synthesized in the liver and present in high concentrations in bile." ; rdfs:label "Decreased circulating chenodeoxycholic acid concentration" ; rdfs:subClassOf obo:HP_0030985 . obo:HP_0034049 obo:IAO_0000115 "An increased amount of prostaglandin E2 in the urine." ; dc:date "2021-10-19T16:53:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urinary PGE2 level" ; a owl:Class ; rdfs:label "Elevated urinary prostaglandin E2 level" ; rdfs:subClassOf obo:HP_0003527 . obo:HP_0034050 obo:IAO_0000115 "An increased amount of prostaglandin E2 metabolite (PGE-M) in the urine." ; dc:date "2021-10-19T16:57:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In vivo, PGE2 is rapidly converted to its 13,14-dihydro-15-keto metabolite, with more than 90% of circulating PGE2 cleared by a single passage through the lungs. This metabolite is chemically unstable and undergoes a variable amount of degradation to prostaglandin A (PGA) products. Thus, plasma and urine samples from patients actually contain very little intact PGE2, and the PGE2 metabolites (PGEM) can be measured to provide a more reliable estimate of actual PGE2 production." ; rdfs:label "Elevated urinary prostaglandin E2 metabolite level" ; rdfs:subClassOf obo:HP_0003527 . obo:HP_0034051 obo:IAO_0000115 "Underdevelopment of the frontal part (anterior crus or anterior limb) of the internal capsule." ; dc:date "2021-10-19T17:09:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypoplastic anterior limbs of the internal capsule" ; rdfs:subClassOf obo:HP_0012502 . obo:HP_0034052 obo:IAO_0000115 "Difficulty or reduced ability to walk on toes. Toe-walking can be tested as a part of the neurological examination. Foot plantar flexion weakness leads to difficulties in walking on toes." ; dc:date "2021-10-19T17:13:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired toe-walking ability" ; rdfs:subClassOf obo:HP_0001288 . obo:HP_0034053 dc:date "2021-11-24T11:39:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Reduced activity of acid ceramidase (AC; alsoknown as N-acylsphingosine amidohydrolase; EC 3.5.1.23). The test is usually performed in cultured patient fibroblasts." ; rdfs:label "Decreased acid ceramidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034054 obo:IAO_0000115 "Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles." ; dc:date "2021-11-24T12:09:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The formation of Probst bundles is the most common structural anomaly associated with callosal dysgenesis." ; rdfs:label "Probst bundles" ; rdfs:subClassOf obo:HP_0001273 . obo:HP_0034055 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), which is encoded by CYP11A1 cytochrome P450 family 11 subfamily A member 1 (Gene ID:1583)." ; dc:date "2021-12-18T14:02:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-P450scc" ; a owl:Class ; rdfs:label "Anti-side-chain cleavage enzyme antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034056 obo:IAO_0000115 "An increased amount of calprotectin in the feces." ; dc:date "2021-11-27T14:02:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Calprotectin is a calcium- and zinc-binding protein of the S-100 protein family which is mainly found within neutrophils and throughout the human body. The presence of calprotectin in faeces is a consequence of neutrophil migration into the gastrointestinal tissue due to an inflammatory process. Faecal calprotectin concentrations demonstrate good correlation with intestinal inflammation and faecal calprotectin is used as a biomarker in gastrointestinal disorders." ; rdfs:label "Increased fecal calprotectin level" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034057 obo:IAO_0000115 "Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate." ; dc:date "2021-11-27T19:01:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal anomaly" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0034058 obo:IAO_0000115 "Any structural anomaly of the fetus." ; dc:date "2021-11-27T19:03:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Structural fetal anomaly", "Structural foetal anomaly" ; a owl:Class ; rdfs:label "Abnormal fetal morphology" ; rdfs:subClassOf obo:HP_0034057 . obo:HP_0034059 obo:IAO_0000115 "Any functional anomaly of the fetus." ; dc:date "2021-11-27T19:03:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Functional fetal anomaly", "Functional foetal anomaly" ; a owl:Class ; rdfs:label "Abnormal fetal physiology" ; rdfs:subClassOf obo:HP_0034057 . obo:HP_0034060 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by eating fava beans." ; dc:date "2021-11-27T19:36:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The fava bean plant (Vicia faba) was probably one of the first plants to be domesticated, V. faba contains high concentrations of two beta-glucosides (up to 2% in dry weight): vicine and convicine. On ingestion of fava beans, vicine and convicine undergo hydrolysis by glucosidases present both in the beans and in the gastrointestinal tract, releasing the respective aglycones: divicine (2,6-diamino-4,5-dihydroxypyrimidine) and isouramil (6-amino-2,4,5-trihydroxypyrimidine). These highly reactive redox compounds have antifungal and pesticide activity, which probably helps prevent fava beans from rotting, but the compounds are also capable of triggering a favism attack in persons with glucose-6-phosphate dehydrogenase (G6PD) deficiency." ; rdfs:label "Triggered by fava bean ingestion" ; rdfs:subClassOf obo:HP_0033793 . obo:HP_0034061 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against steroid 17alpha-hydroxylase." ; dc:date "2021-12-18T14:04:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-P450C17" ; a owl:Class ; rdfs:label "Anti-steroid 17alpha-hydroxylase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034062 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against insulin." ; dc:date "2021-12-18T14:09:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IAA positivity", "Insulin autoantibodies" ; a owl:Class ; rdfs:label "Anti-insulin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034063 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against tyrosine phosphatase IA-2." ; dc:date "2021-12-18T14:13:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-IA2 antibody positivity", "Anti-IA2A", "ICA512" ; a owl:Class ; rdfs:label "Anti-islet antigen-2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034064 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against salivary protein." ; dc:date "2021-12-18T14:18:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-SP1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-salivary protein antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034065 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against zinc transporter 8." ; dc:date "2021-12-18T14:20:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti ZnT8 autoantibodies" ; a owl:Class ; rdfs:label "Anti-Zinc transporter 8 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034066 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase VI." ; dc:date "2021-12-18T14:22:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CA6 antibody positivity" ; a owl:Class ; rdfs:label "Anti-carbonic anhydrase VI antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034067 obo:IAO_0000115 "Formation of lumps of tonofilaments, which are bundles of keratin filaments. In some but not all epithelia, keratin filaments are conspicuously bundled as tonofilaments. Inside the cell they braid the nucleus, span through the cytoplasm and are attached to the cytoplasmic plaques of the typical epithelial cell-cell junctions, the desmosomes." ; dc:date "2021-12-18T14:25:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clumping of the keratin tonofilaments" ; a owl:Class ; rdfs:label "Tonofilament clumping" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0034068 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against plasminogen binding peptide." ; dc:date "2021-12-18T14:30:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PBP antibody positivity" ; a owl:Class ; rdfs:label "Anti-plasminogen binding peptide antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034069 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against parotid secretory protein." ; dc:date "2021-12-18T14:33:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PSP antibody positivity" ; a owl:Class ; rdfs:label "Anti-parotid secretory protein antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034070 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against enterocytes." ; dc:date "2021-12-18T14:35:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "AEA" ; a owl:Class ; rdfs:label "Anti-enterocyte antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034071 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against 21-hydroxylase." ; dc:date "2021-12-18T14:39:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-P450c21" ; a owl:Class ; rdfs:label "Anti-21-hydroxylase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034072 obo:IAO_0000115 "Any deviation from the normal appearing echogenicity of the fetal bone. Echogenicity refers to the ability of tissue to reflect ultrasound waves back toward the transducer and produce an echo. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. The higher the echogenicity of tissues, the brighter they appear on ultrasound imaging." ; dc:date "2021-12-18T14:48:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hyperechoic structures are seen as brighter on the US image relative to surrounding structures due to higher reflectivity of the US beam. Isoechoic structures are seen as bright as surrounding structures on conventional US imaging due to similar reflectivity to the US beam. Hypoechoic structures are seen as darker relative to the surrounding structures on the US image due to the US beam being reflected to a lesser extent. Anechoic structures that lack internal reflectors fail to reflect the US beam to the transducer and are seen as homogeneously black on imaging." ; rdfs:label "Abnormal fetal long-bone echogenicity" ; rdfs:subClassOf obo:HP_0025662 . obo:HP_0034073 obo:IAO_0000115 "An abnormally decreased echogenicity of fetal long bones in a prenatal sonographic investigation. Ths finding is due to hypomineralization and can be seen in some disorders such as hypophosphatasia, osteogenesis imperfecta, and achondrogenesis." ; dc:date "2021-12-18T14:49:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced fetal long bone echogenicity" ; rdfs:subClassOf obo:HP_0034072 . obo:HP_0034074 obo:IAO_0000115 "An abnormally elevated echogenicity of fetal long bones in a prenatal sonographic investigation. This finding is due to hypermineralization." ; dc:date "2021-12-18T14:51:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased fetal long bone echogenicity" ; rdfs:subClassOf obo:HP_0034072 . obo:HP_0034075 obo:IAO_0000115 "Reduced circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100." ; dc:date "2021-12-18T14:54:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein B concentration" ; rdfs:subClassOf obo:HP_0033459 . obo:HP_0034076 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ribosome Po." ; dc:date "2021-12-19T02:20:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-ribosome Po antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034077 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against C1q." ; dc:date "2021-12-19T02:21:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-C1q antibody positivity" ; a owl:Class ; rdfs:label "Anti-complement component C1q antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034078 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-A." ; dc:date "2021-12-19T02:24:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CENP-A antibody positivity" ; a owl:Class ; rdfs:label "Anti-centromere protein A antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034079 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-B." ; dc:date "2021-12-19T02:26:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CENP-B antibody positivity" ; a owl:Class ; rdfs:label "Anti-centromere protein B antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034080 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U3 RNP." ; dc:date "2021-12-19T02:28:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-fibrillarin antibody positivity" ; a owl:Class ; rdfs:label "Anti-U3 RNP antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034081 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Th/To." ; dc:date "2021-12-19T02:30:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Th/To antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034082 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against bicaudal D2." ; dc:date "2021-12-19T02:31:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-BICD2 antibody positivity" ; a owl:Class ; rdfs:label "Anti-bicaudal D2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034083 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Nor90." ; dc:date "2021-12-19T02:32:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Nor90 antibody positivity" ; a owl:Class ; rdfs:label "Anti-nucleolus-organizing region antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034084 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl ethanolamine." ; dc:date "2021-12-19T02:34:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidyl ethanolamine antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034085 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl100." ; dc:date "2021-12-19T02:35:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-PM-Scl100 antibody positivity" ; rdfs:subClassOf obo:HP_0033560 . obo:HP_0034086 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl75." ; dc:date "2021-12-19T02:35:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-PM-Scl75 antibody positivity" ; rdfs:subClassOf obo:HP_0033560 . obo:HP_0034087 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U11/U12 RNP." ; dc:date "2021-12-19T02:36:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-U11/U12 RNP antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034088 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ku." ; dc:date "2021-12-19T02:37:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Ku antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034089 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against B23." ; dc:date "2021-12-19T02:38:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-B23 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034090 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against RuvBL1/2." ; dc:date "2021-12-19T02:39:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-RuvBL1/2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034091 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against platelet derived growth factor receptor." ; dc:date "2021-12-19T02:40:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PDGFR antibody positivity" ; a owl:Class ; rdfs:label "Anti-platelet derived growth factor receptor" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034092 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cyclic citrullinated peptide." ; dc:date "2021-12-19T02:42:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CCP antibody positivity" ; a owl:Class ; rdfs:label "Anti-cyclic citrullinated peptide antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034093 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro52/TRIM21." ; dc:date "2021-12-19T02:43:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ro52 antibody positivity" ; a owl:Class ; rdfs:label "Anti-Ro52/TRIM21 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034094 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin receptor type-1." ; dc:date "2021-12-19T02:44:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-AT1R antibody positivity" ; a owl:Class ; rdfs:label "Anti-angiotensin receptor type-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034095 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endothelin-1 type A receptor." ; dc:date "2021-12-19T02:46:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-ETAR antibody positivity" ; a owl:Class ; rdfs:label "Anti-endothelin-1 type A receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034096 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidic acid." ; dc:date "2021-12-19T02:50:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidic acid antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034097 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl choline." ; dc:date "2021-12-19T14:55:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidyl choline antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034098 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl glycerol." ; dc:date "2021-12-19T14:56:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidyl glycerol antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034099 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl inositol." ; dc:date "2021-12-19T14:57:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidyl inositol antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034100 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl serine." ; dc:date "2021-12-19T14:58:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-phosphatidyl serine antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034101 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against annexin-V." ; dc:date "2021-12-19T14:59:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-annexin-V antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034102 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against sphingolipids." ; dc:date "2021-12-19T15:00:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-sphingolipid antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034103 obo:IAO_0000115 "Ganglioside-monosialic acid (GM1) is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury" ; dc:date "2021-12-23T11:18:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-ganglioside-monosialic acid antibody positivity" ; a owl:Class ; rdfs:label "Anti-GM1 antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034104 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neutrophil elastase." ; dc:date "2021-12-19T15:02:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-neutrophil elastase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034105 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transcription intermediary factor-1gamma." ; dc:date "2021-12-19T15:06:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-TIF-1gamma antibody positivity", "Anti-TIF1-gamma antibody positivity" ; a owl:Class ; rdfs:label "Anti-transcription intermediary factor-1gamma antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034106 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Su antigen/argonaute 2." ; dc:date "2021-12-19T15:08:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ago2 antibody positivity", "Anti-Su antibody positivity" ; a owl:Class ; rdfs:label "Anti-Su antigen/argonaute 2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034107 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against p53." ; dc:date "2021-12-19T15:09:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-p53 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034108 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Y-box protein-1." ; dc:date "2021-12-19T15:10:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-YB 1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-Y-box protein-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034109 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GW182." ; dc:date "2021-12-19T15:12:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GW182 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034110 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ge-1." ; dc:date "2021-12-19T15:14:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ge-1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-Gerbich phenotype 1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034111 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against MIT3." ; dc:date "2021-12-19T15:15:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-MIT3 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034112 obo:IAO_0000115 "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GM1." ; dc:date "2021-12-23T11:22:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GM1 IgG antibody positivity" ; rdfs:subClassOf obo:HP_0034103 . obo:HP_0034113 obo:IAO_0000115 "The presence of type I liver-kidney microsomal autoantibodies (immunoglobulins) in the blood circulation." ; obo:IAO_0100001 "HP:0030908" ; dc:date "2021-12-19T15:18:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This term was merged with HP:0030908 Liver kidney microsome type 1 antibody positivity, as it was a duplicate." ; rdfs:label "obsolete Anti-type I liver-kidney microsomal antibody positivity" ; owl:deprecated true . obo:HP_0034114 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against hexokinase-1." ; dc:date "2021-12-19T15:21:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-HK-1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-hexokinase-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034115 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Kelch like protein 12." ; dc:date "2021-12-19T15:22:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-KLHL-12 antibody positivity" ; a owl:Class ; rdfs:label "Anti-Kelch like protein 12 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034116 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against thyrotropin receptor antibody." ; dc:date "2021-12-19T15:25:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-thyrotropin receptor antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034117 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin-converting enzyme 2." ; dc:date "2021-12-19T15:26:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-ACE2 antibody positivity" ; a owl:Class ; rdfs:label "Anti-angiotensin-converting enzyme 2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034118 obo:IAO_0000115 "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GM1." ; dc:date "2021-12-23T11:23:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GM1 IgM antibody positivity" ; rdfs:subClassOf obo:HP_0034103 . obo:HP_0034119 obo:IAO_0000115 "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a." ; dc:date "2021-12-23T11:27:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1a IgG antibody positivity" ; rdfs:subClassOf obo:HP_0034121 . obo:HP_0034120 obo:IAO_0000115 "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a." ; dc:date "2021-12-23T11:41:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1a IgM antibody positivity" ; rdfs:subClassOf obo:HP_0034121 . obo:HP_0034121 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a." ; dc:date "2021-12-23T11:42:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1a antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034122 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b." ; dc:date "2021-12-23T11:43:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GQ1b antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034123 obo:IAO_0000115 "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b." ; dc:date "2021-12-23T11:44:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GQ1b IgM antibody positivity" ; rdfs:subClassOf obo:HP_0034122 . obo:HP_0034124 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." ; dc:date "2021-12-23T11:46:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1b antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034125 obo:IAO_0000115 "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." ; dc:date "2021-12-23T11:47:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1b IgM antibody positivity" ; rdfs:subClassOf obo:HP_0034124 . obo:HP_0034126 obo:IAO_0000115 "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." ; dc:date "2021-12-23T11:48:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GD1b IgG antibody positivity" ; rdfs:subClassOf obo:HP_0034124 . obo:HP_0034127 obo:IAO_0000115 "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b." ; dc:date "2021-12-23T11:49:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GQ1b IgG antibody positivity" ; rdfs:subClassOf obo:HP_0034122 . obo:HP_0034128 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside." ; dc:date "2021-12-23T11:53:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GT1a antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034129 obo:IAO_0000115 "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside." ; dc:date "2021-12-23T11:53:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GT1a IgM antibody positivity" ; rdfs:subClassOf obo:HP_0034128 . obo:HP_0034130 obo:IAO_0000115 "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside." ; dc:date "2021-12-23T11:54:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GT1a IgG antibody positivity" ; rdfs:subClassOf obo:HP_0034128 . obo:HP_0034131 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1b ganglioside." ; dc:date "2021-12-23T11:56:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GT1b antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034132 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM2." ; dc:date "2021-12-23T11:58:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GM2 antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034133 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM3." ; dc:date "2021-12-23T11:58:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GM3 antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034134 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM4." ; dc:date "2021-12-23T12:00:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-GM4 antibody positivity" ; rdfs:subClassOf obo:HP_0031810 . obo:HP_0034135 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF155." ; dc:date "2021-12-23T12:54:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-NF155 antibody positivity" ; a owl:Class ; rdfs:label "Anti-neurofascin-155 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034136 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF186." ; dc:date "2021-12-23T12:56:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-NF186 antibody positivity" ; a owl:Class ; rdfs:label "Anti-neurofascin 186 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034137 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CNTN1." ; dc:date "2021-12-23T12:58:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CNTN1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-contactin-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034138 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-contactin-associated protein 1." ; dc:date "2021-12-23T13:00:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-CASPR1 antibody positivity" ; a owl:Class ; rdfs:label "Anti-contactin-associated protein 1 antibody positivity" ; rdfs:subClassOf obo:HP_0034137 . obo:HP_0034139 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE." ; dc:date "2021-12-23T13:30:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-SAE antibody positivity", "Anti-small ubiquitin-like modifier-1 activating enzyme antibody positivity" ; a owl:Class ; rdfs:label "Anti-SUMO-activating enzyme antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034140 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 1." ; dc:date "2021-12-23T13:33:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-SUMO-activating enzyme subunit 1 antibody positivity" ; rdfs:subClassOf obo:HP_0034139 . obo:HP_0034141 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 2." ; dc:date "2021-12-23T13:34:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-SAE 2 antibody positivity" ; a owl:Class ; rdfs:label "Anti-SUMO-activating enzyme subunit 2 antibody positivity" ; rdfs:subClassOf obo:HP_0034139 . obo:HP_0034142 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NXP-2." ; dc:date "2021-12-23T13:36:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-MJ/NXP-2 antibody positivity", "Anti-NXP-2 antibody positivity" ; a owl:Class ; rdfs:label "Anti-nuclear matrix protein-2 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034143 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against threonyl-tRNA synthetase." ; dc:date "2021-12-23T13:39:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PL-7 antibody positivity" ; a owl:Class ; rdfs:label "Anti-threonyl-tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034144 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro60." ; dc:date "2021-12-23T13:47:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ro60 antibody positivity" ; a owl:Class ; rdfs:label "Anti-hY-RNA complex antibody positivity" ; rdfs:subClassOf obo:HP_0033476 . obo:HP_0034145 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against alanyl-tRNA synthetase." ; dc:date "2021-12-23T13:53:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PL-12 antibody positivity" ; a owl:Class ; rdfs:label "Anti-alanyl-tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034146 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycyl tRNA-synthetase." ; dc:date "2021-12-23T13:55:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-EJ antibody positivity" ; a owl:Class ; rdfs:label "Anti-glycyl tRNA-synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034147 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a tRNA synthetase enzyme." ; dc:date "2021-12-23T13:56:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Antibodies reactive with aminoacyl-tRNA synthetases (ARS) can be detected in patients with polymyositis and dermatomyositis. Eight anti-ARS Abs have been described: anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-EJ), anti-isoleucyl (anti-OJ), anti-asparaginyl (anti-KS), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha) tRNAs." ; rdfs:label "Anti-aminoacyl-tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034148 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against isoleucyl tRNA-synthetase." ; dc:date "2021-12-23T13:59:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-OJ antibody positivity" ; a owl:Class ; rdfs:label "Anti-isoleucyl tRNA-synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034149 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phenylalanyl tRNA synthetase." ; dc:date "2021-12-23T14:02:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Zo alpha antibody positivity", "Anti-Zo antibody positivity", "Phenylanyl-t-RNA synthetase alpha antibody positivity" ; a owl:Class ; rdfs:label "Anti-phenylalanyl tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034150 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against tyrosyl-tRNA synthetase." ; dc:date "2021-12-23T14:03:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ha antibody positivity" ; a owl:Class ; rdfs:label "Anti-tyrosyl-tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034151 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against asparaginyl-tRNA synthetase." ; dc:date "2021-12-23T14:05:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-KS antibody positivity" ; a owl:Class ; rdfs:label "Anti-asparaginyl-tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034152 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase." ; dc:date "2021-12-23T14:07:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0033029" ; oboInOwl:hasExactSynonym "Anti-JO1 antibody positivity", "Anti-Jo-1 antibody positivity" ; a owl:Class ; rdfs:comment "Histidyl-tRNA synthetase (HRS = Jo-1) represents a key autoantibody target in the anti-synthetase syndrome that is marked by myositis as well as extra-muscular organ complications including interstitial lung disease (ILD)." ; rdfs:label "Anti-histidyl tRNA synthetase antibody positivity" ; rdfs:subClassOf obo:HP_0034147 . obo:HP_0034153 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cytosolic-5-nucleotidase-1A (cN1A)." ; dc:date "2021-12-23T14:09:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-cN1A antibody positivity" ; a owl:Class ; rdfs:label "Anti-cytosolic-5-nucleotidase-1A antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034154 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ki." ; dc:date "2021-12-23T14:11:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Ki antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034155 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against sp100. Autoantibodies causing the MND pattern are directed against sp100, sp140, promyelocytic leukemia nuclear body proteins (PML) or ubiquitin-like modifier (SUMO) proteins, while in the punctate nuclear envelope pattern, the target antigens are gp210, nucleoporin-62 or laminin B receptor proteins." ; dc:date "2021-12-23T14:19:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-sp100 antibody positivity" ; rdfs:subClassOf obo:HP_0025353 . obo:HP_0034156 obo:IAO_0000115 "Presence of IgG antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome." ; dc:date "2021-12-23T14:24:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-beta2GPI IgG antibody positivity" ; a owl:Class ; rdfs:label "Anti-beta-2-Glycoprotein I IgG antibody positivity" ; rdfs:subClassOf obo:HP_0032376 . obo:HP_0034157 obo:IAO_0000115 "Presence of IgM antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome." ; dc:date "2021-12-23T14:26:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-beta2GPI IgM antibody positivity" ; a owl:Class ; rdfs:label "Anti-beta-2-Glycoprotein I IgM antibody positivity" ; rdfs:subClassOf obo:HP_0032376 . obo:HP_0034158 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against the tyrosine phossphatase region of islet antigen 2A (this region is a specific part of IA-2). Usually IA-2A are measured using the intracellular portion of IA-2 (IA-2ic) made up of the protein tyrosine phosphatase (PTP) and juxtamembrane (JM) regions." ; dc:date "2021-12-23T15:56:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-PTPA antibody positivity" ; a owl:Class ; rdfs:label "Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity" ; rdfs:subClassOf obo:HP_0034063 . obo:HP_0034159 obo:IAO_0000115 "A localized disorder of bone remodeling. Increased numbers of larger than normal osteoclasts initiate the process at affected skeletal sites, and the increase in bone resorption is followed by an increase in new bone formation, altering bone architecture." ; dc:date "2022-02-19T11:36:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Paget disease is a feature of several Mendelian diseases including Paget disease of bone 3 (OMIM:167250)." ; rdfs:label "Paget disease of bone" ; rdfs:subClassOf obo:HP_0003330 . obo:HP_0034160 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 9 in the blood circulation." ; dc:date "2022-02-19T11:37:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 9 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034161 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 9 in the blood circulation." ; dc:date "2022-02-19T11:38:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 9 concentration" ; rdfs:subClassOf obo:HP_0034160 . obo:HP_0034162 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 10 in the blood circulation." ; dc:date "2022-02-19T11:38:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 10 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034163 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 10 in the blood circulation." ; dc:date "2022-02-19T11:39:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 10 concentration" ; rdfs:subClassOf obo:HP_0034162 . obo:HP_0034164 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 21 in the blood circulation." ; dc:date "2022-02-19T11:39:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 21 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034165 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 21 in the blood circulation." ; dc:date "2022-02-19T11:40:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 21 concentration" ; rdfs:subClassOf obo:HP_0034164 . obo:HP_0034166 obo:IAO_0000115 "An abnormally increased concentration of interleukin 21 in the blood circulation." ; dc:date "2022-02-19T11:40:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating interleukin 21 concentration" ; rdfs:subClassOf obo:HP_0034164 . obo:HP_0034167 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 22 in the blood circulation." ; dc:date "2022-02-19T11:41:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 22 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034168 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 22 in the blood circulation." ; dc:date "2022-02-19T11:41:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 22 concentration" ; rdfs:subClassOf obo:HP_0034167 . obo:HP_0034169 obo:IAO_0000115 "An abnormally increased concentration of interleukin 22 in the blood circulation." ; dc:date "2022-02-19T11:41:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating interleukin 22 concentration" ; rdfs:subClassOf obo:HP_0034167 . obo:HP_0034170 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 23 in the blood circulation." ; dc:date "2022-02-19T11:42:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 23 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034171 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 23 in the blood circulation." ; dc:date "2022-02-19T11:42:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 23 concentration" ; rdfs:subClassOf obo:HP_0034170 . obo:HP_0034172 obo:IAO_0000115 "An abnormally increased concentration of interleukin 23 in the blood circulation." ; dc:date "2022-02-19T11:43:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating interleukin 23 concentration" ; rdfs:subClassOf obo:HP_0034170 . obo:HP_0034173 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 27 in the blood circulation." ; dc:date "2022-02-19T11:43:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 27 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034174 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 27 in the blood circulation." ; dc:date "2022-02-19T11:44:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 27 concentration" ; rdfs:subClassOf obo:HP_0034173 . obo:HP_0034175 obo:IAO_0000115 "An abnormally increased concentration of interleukin 27 in the blood circulation." ; dc:date "2022-02-19T11:44:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating interleukin 27 concentration" ; rdfs:subClassOf obo:HP_0034173 . obo:HP_0034176 obo:IAO_0000115 "Any deviation from the normal range of the concentration of interleukin 17A in the blood circulation." ; dc:date "2022-02-19T11:45:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating interleukin 17A concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034177 obo:IAO_0000115 "An abnormally decreased concentration of interleukin 17A in the blood circulation." ; dc:date "2022-02-19T11:45:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating interleukin 17A concentration" ; rdfs:subClassOf obo:HP_0034176 . obo:HP_0034178 obo:IAO_0000115 "An abnormally increased concentration of interleukin 17A in the blood circulation." ; dc:date "2022-02-19T11:45:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating interleukin 17A concentration" ; rdfs:subClassOf obo:HP_0034176 . obo:HP_0034179 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of the vertebral artery ." ; dc:date "2022-02-19T11:49:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vertebral artery aneurysm" ; rdfs:subClassOf obo:HP_0030321 . obo:HP_0034180 obo:IAO_0000115 "Abnormal joined appearance of the caudate and putamen with an absence of the anterior limb of the internal capsule." ; dc:date "2022-02-19T12:29:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The putamen, combined with the globus pallidus, forms the lentiform nucleus; and with the caudate nucleus, it shapes the striatum, which is a subcortical structure that forms the basal ganglia." ; rdfs:label "Fusion of the caudate and putamen" ; rdfs:subClassOf obo:HP_0002339, obo:HP_0031982 . obo:HP_0034181 obo:IAO_0000115 "Absence or underdevelopment of the liver." ; dc:date "2022-02-20T12:02:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the liver" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0034182 obo:IAO_0000115 "Anatomically the liver is divided into right and left lobes based on the attachment of its peritoneal ligaments. This term refers to a developmental anomaly characterzied by the underdevelopment of one of the lobes of the liver. This is a rare and usually asymptomatic anomaly that can be detected incidentally on cross sectional imaging with computed tomography or magnetic resonance imaging." ; dc:date "2022-02-20T12:03:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Segmental hypoplasia of liver" ; rdfs:subClassOf obo:HP_0034181 . obo:HP_0034183 obo:IAO_0000115 "Spastic weakness found in both lower extremities and one upper extremity." ; dc:date "2022-02-20T12:44:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spastic triplegia" ; rdfs:subClassOf obo:HP_0034353, obo:HP_0100021 . obo:HP_0034184 obo:IAO_0000115 "An abnormally elevated concentration of insulin like growth factor binding protein acid labile subunit level in the blood circulation." ; dc:date "2022-02-20T12:50:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating IGFALS contration" ; a owl:Class ; rdfs:label "Increased insulin like growth factor binding protein acid labile subunit concentration" ; rdfs:subClassOf obo:HP_0031034 . obo:HP_0034185 obo:IAO_0000115 "A type of mild median cleft lip in which the central tubercle of the upper lip is replaced by a mucosal cleft in the midline." ; dc:date "2022-02-20T13:00:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:25535458." ; rdfs:label "Median pseudocleft lip" ; rdfs:subClassOf obo:HP_0000161 . obo:HP_0034186 obo:IAO_0000115 "Patella alta is a patella that rides abnormally high in relation to the femur, the femoral trochlea, or the tibia, with decreased bony stability requiring increased knee flexion angles to engage the trochlea." ; dc:date "2022-02-26T13:06:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An abnormally high patella may therefore insufficiently engage the proximal trochlea groove both in extension and in the early phase of knee flexion - making it one of the potential risk factors for patellar instability. Accordingly, patella alta is present in 30% of patients with recurrent patellar dislocation." ; rdfs:label "Patella alta" ; rdfs:subClassOf obo:HP_0003045 . obo:HP_0034187 obo:IAO_0000115 "A developmental defect in a the clavicule leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or false joint)." ; dc:date "2022-03-09T20:08:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Clavicular pseudarthrosis" ; rdfs:subClassOf obo:HP_0000889 . obo:HP_0034188 obo:IAO_0000115 "Position of the liver across the middle of the body instead of being in its normal position to the right of the stomach." ; dc:date "2022-03-09T20:11:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Midline liver" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0034189 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid-stimulating hormone." ; dc:date "2022-03-09T20:41:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-TSH receptor antibody positivity", "TRAbs" ; a owl:Class ; rdfs:label "Anti-thyroid-stimulating hormone receptor antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034190 obo:IAO_0000115 "Abnormal functionality of the fetal cardiovascular system." ; dc:date "2022-03-12T23:26:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal cardiovascular physiology" ; rdfs:subClassOf obo:HP_0011025, obo:HP_0034059 . obo:HP_0034191 obo:IAO_0000115 "Increased peak systolic velocity of the fetal middle cerebral artery (MCA) as evaluated by Doppler ultrasound." ; dc:date "2022-03-12T23:26:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The technique for MCA peak systolic velocity measurement involves an axial section through the fetal head that includes the thalami and cavum septum pellucidum is obtained and the circle of Willis visualized with color or power Doppler. The MCA is examined close to its origin from the internal carotid artery. The sample volume should be placed in the center of the vessel and the angle between the ultrasound beam and the direction of blood flow kept as close to 0 degrees as possible. Angle correction can be used if required. The highest peak systolic waveform is measured, in the absence of fetal breathing movements. An elevated MCA Doppler measurement indicates that the fetus is likely to be anemic, but this measurement is not perfectly sensitive or specific." ; rdfs:label "Elevated fetal middle cerebral artery peak systolic velocity" ; rdfs:subClassOf obo:HP_0034190 . obo:HP_0034192 obo:IAO_0000115 "Pulmonary embolism is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung." ; dc:date "2022-03-16T14:05:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pulmonary embolism (PE) is the most dangerous form of venous thromboembolism, and undiagnosed or untreated PE can be fatal. Acute PE is associated with right ventricular dysfunction, which can lead to arrhythmia, haemodynamic collapse and shock. Furthermore, individuals who survive PE can develop post-PE syndrome, which is characterized by chronic thrombotic remains in the pulmonary arteries, persistent right ventricular dysfunction, decreased quality of life and/or chronic functional limitations." ; rdfs:label "Pulmonary thromboembolism" ; rdfs:subClassOf obo:HP_0001907 . obo:HP_0034193 obo:IAO_0000115 "Cleavage within the epidermal keratinocytes, which is the innermost layer of the epidermis and consists of proliferating cells that give rise to the outer layers of the epidermis." ; dc:date "2022-03-16T14:18:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blistering with cleavage within basal keratinocytes", "Cleavage within the basal keratinocyte layer" ; a owl:Class ; rdfs:comment "Cleavage in epidermolysis bullosa simplex occurs within the basal keratinocytes." ; rdfs:label "Stratum basale cleavage" ; rdfs:subClassOf obo:HP_0033802 . obo:HP_0034194 obo:IAO_0000115 "Cleavage within the suprabasal cell layer of the epidermis, which lies directly above the basal layer and is composed of five to ten layers of cells." ; dc:date "2022-03-16T14:20:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blistering with suprabasal clefting" ; a owl:Class ; rdfs:label "Suprabasal cleavage" ; rdfs:subClassOf obo:HP_0033802 . obo:HP_0034195 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a muscle relaxant such as suxamethonium and mivacurium." ; dc:date "2022-04-07T13:21:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by muscle relaxant" ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0034196 obo:IAO_0000115 "A developmental defect characterized by lack of formation of the ductus venosus (a shunt that allows oxygenated blood in the umbilical vein to bypass the liver in the fetal circulation)." ; dc:date "2022-04-07T14:12:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Agenesis of the ductus venosus" ; a owl:Class ; rdfs:comment "The ductus venosus (DV) plays an essential role in the fetal circulation because it allows the oxygenated placental blood to bypass the liver and enables preferential flow via the right atrium and foramen ovale to the left atrium. Furthermore, normal umbilical flow via DV is involved in the normal development of the intrahepatic portal venous system. The lack of critical anastomoses between the portal and umbilical venous system and hepatic-systemic venous system results in agenesis of ductus venosus and shunting of umbilical blood through an aberrant vessel. Between 1 in 2532 to 1 in 556 fetuses are affected." ; rdfs:label "Ductus venosus agenesis" ; rdfs:subClassOf obo:HP_0010948 . obo:HP_0034197 obo:IAO_0000115 "This term refers to a phenotypic feature that was first observed prior to birth during the third trimester, which is defined as 28 weeks and zero days (28+0) of gestation and beyond." ; dc:date "2022-04-07T15:49:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Third trimester onset" ; rdfs:subClassOf obo:HP_0011461 . obo:HP_0034198 obo:IAO_0000115 "This term refers to a phenotypic feature that was first observed prior to birth during the second trimester, which comprises the range of gestational ages from 14 0/7 weeks to 27 6/7 (inclusive)." ; dc:date "2022-04-07T16:11:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Second trimester onset" ; rdfs:subClassOf obo:HP_0011461 . obo:HP_0034199 obo:IAO_0000115 "This term refers to a phenotypic feature that was first observed prior to birth in the first trimester during the early fetal period, which is defined as 11 0/7 to 13 6/7 weeks of gestation (inclusive)." ; dc:date "2022-04-07T16:13:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Early fetal onset", "Early foetal onset" ; a owl:Class ; rdfs:label "Late first trimester onset" ; rdfs:subClassOf obo:HP_0011461 . obo:HP_0034200 obo:IAO_0000115 "Any deviation from the normal concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine." ; dc:date "2022-04-10T10:30:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal CSF homovanillic acid concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034201 obo:IAO_0000115 "Elevated concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine." ; dc:date "2022-04-10T10:31:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased CSF homovanillic acid concentration" ; rdfs:subClassOf obo:HP_0034200 . obo:HP_0034202 dc:date "2022-04-10T10:45:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal iduronate sulfatase concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034203 obo:IAO_0000115 "An decreased level of iduronate-2-sulfatase activity in the blood circulation." ; dc:date "2022-04-10T10:46:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased iduronate sulfatase level" ; rdfs:subClassOf obo:HP_0034202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000008894 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034204 obo:IAO_0000115 "Decreased concentration of C1-esterase inhibitor (C1INH) in the blood circulation." ; dc:date "2022-04-10T10:49:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "C1-esterase inhibitor (C1INH) is an acute phase reactant and a serine protease inhibitor (serpin). Serpins inhibit the steps in the lectin complement pathway as well as kinin-producing pathways. While C1 inhibitor has many functions, its function in the kinin pathway leads to angioedema ctivated factor XII of the coagulation cascade and kallikrein catalyze the cleavage of kininogen, which produces bradykinin. C1 inhibitor usually limits this bradykinin production by inhibiting kallikrein and factor XIIa. Bradykinin is a potent vasodilator due to multifactorial downstream effects on the smooth muscle in blood vessels." ; rdfs:label "Decreased circulating C1-esterase inhibitor concentration" ; rdfs:subClassOf obo:HP_0005339 . obo:HP_0034205 obo:IAO_0000115 "Iniencephaly is a rare neural tube defect involving dysmorphic spine and abnormal fusion of the portion of the occipital skull with the back. It results in extreme fixed head retroflexion." ; dc:date "2022-04-10T10:56:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Iniencephaly" ; rdfs:subClassOf obo:HP_0034237 . obo:HP_0034206 obo:IAO_0000115 "An anomalous structural finding of the fetal central nervous system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dc:date "2022-04-10T11:09:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal fetal CNS morphology", "Abnormal foetal CNS morphology" ; a owl:Class ; rdfs:label "Abnormal fetal central nervous system morphology" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034207 obo:IAO_0000115 "An anomalous structural finding of the fetal gastrointestinal system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dc:date "2022-04-10T11:11:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal gastrointestinal system morphology" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034208 obo:IAO_0000115 "Abnormal bleeding inside the skull (cranium) of a fetus." ; dc:date "2022-04-10T11:12:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fetal intracranial hemorrhage occurs when a blood vessel within or adjacent to the brain ruptures or leaks, resulting in bleeding into the brain or surrounding area. Fetal intracranial hemorrhage can result in disruption of blood flow to the developing brain (ischemia). Addditionally, accumulation of blood can compress brain tissue." ; rdfs:label "Fetal intracranial hemorrhage" ; rdfs:subClassOf obo:HP_0002170, obo:HP_0034206 . obo:HP_0034209 obo:IAO_0000115 "A type of fetal intracranial hemorrhage located in the subependymal germinal matrix below the frontal horns of the lateral ventricles in the caudothalamic notch." ; dc:date "2022-04-10T11:31:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade I fetal intracranial hemorrhage", "Grade I foetal intracranial haemorrhage" ; a owl:Class ; rdfs:comment "Subependymal hemorrhage originates from the germinal matrix and appears on sonography as echogenic material located below the frontal horns in the floor of the lateral ventricle within the caudothalamic notch. Acute hemorrhage appears sonographically as echogenic and homogeneous; the hemorrhage changes over time to a more complex appearance with an echogenic external lining and internal sonolucent center and then eventually becomes cystic in nature." ; rdfs:label "Fetal subependymal hemorrhage" ; rdfs:subClassOf obo:HP_0034210 . obo:HP_0034210 obo:IAO_0000115 "A type of fetal intracranial hemorrhage with bleeding into the ventricular system of the brain." ; dc:date "2022-04-10T11:39:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The evolution of the ultrasonographic pattern of intraventricular hemorrhage (IVH) is that fresh blood clots appear as homogeneously echogenic areas, separate from the choroid plexus. Over the course of several weeks some blood clots develop a complex appearance, with an external echogenic lining and an internal sonolucent core." ; rdfs:label "Fetal intraventricular hemorrhage" ; rdfs:subClassOf obo:HP_0034208 . obo:HP_0034211 obo:IAO_0000115 "A type of fetal intracranial hemorrhage with bleeding into the parenchyma (tissue) of the brain." ; dc:date "2022-04-10T12:03:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal cerebral parenchymal hemorrhage" ; rdfs:subClassOf obo:HP_0034208 . obo:HP_0034212 obo:IAO_0000115 "A type of fetal intracranial hemorrhage with bleeding that occurs within the skull but outside of the brain tissue itself (into the epidural, subdural, or arachnoid space)." ; dc:date "2022-04-10T12:07:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal extra-axial hemorrhage" ; rdfs:subClassOf obo:HP_0034208 . obo:HP_0034213 obo:IAO_0000115 "A type of fetal intracranial hemorrhage that occurs in the posterior cranial fossa, which is the part of the cranial cavity that is located between the foramen magnum and tentorium cerebelli and contains the brainstem and cerebellum." ; dc:date "2022-04-10T12:12:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal posterior fossa hemorrhage" ; rdfs:subClassOf obo:HP_0034208 . obo:HP_0034214 obo:IAO_0000115 "A type of fetal intraventricular hemorrhage characterized by clear hemorrhage spillover to the ventricles filling less than 50% of the lateral ventricle and without ventriculomegaly of greater than 15 mm in the transverse diameter of the lateral ventricular atrium." ; dc:date "2022-04-10T12:15:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade II fetal intracranial hemorrhage", "Grade II foetal intracranial haemorrhage" ; a owl:Class ; rdfs:label "Fetal intraventricular hemorrhage without ventriculomegaly" ; rdfs:subClassOf obo:HP_0034210 . obo:HP_0034215 obo:IAO_0000115 "A type of fetal intracranial hemorrhage that occurs in the hemisphere of the cerebellum." ; dc:date "2022-04-10T12:17:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal cerebellar hemisphere hemorrhage" ; rdfs:subClassOf obo:HP_0034213 . obo:HP_0034216 obo:IAO_0000115 "A type of fetal intracranial hemorrhage that occurs in the vermis of the cerebellum." ; dc:date "2022-04-10T12:20:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal cerebellar vermis hemorrhage" ; rdfs:subClassOf obo:HP_0034213 . obo:HP_0034217 obo:IAO_0000115 "Inability to visualize the fetal bladder on targeted prenatal sonography examination. The fetal bladder can be visualized with sonography as a midline, fluid-filled structure in the pelvis as early as 10-12 weeks of gestation. The normal fetus voids at least once an hour but never completely empties the urinary bladder. The fetal bladdder should be consistently imaged after 13 weeks of gestation." ; dc:date "2022-04-10T12:22:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sonographic non-visualized fetal bladder" ; rdfs:subClassOf obo:HP_0034242 . obo:HP_0034218 obo:IAO_0000115 "A type of fetal intraventricular hemorrhage (IVH) characterized by spillover to ventricles with flooding of 50% or more of one or both lateral ventricles accrued accompanying ventriculomegaly, but with no apparent brain parenchymal injury. This type of IVH may be defined as a diameter exceeding 15 mm in the transverse diameter of the lateral ventricular atrium as visualiuzed by prenatal sonography." ; dc:date "2022-04-10T12:23:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade III fetal intracranial hemorrhage", "Grade III foetal intracranial haemorrhage" ; a owl:Class ; rdfs:label "Fetal intraventricular hemorrhage with ventriculomegaly" ; rdfs:subClassOf obo:HP_0034210 . obo:HP_0034219 obo:IAO_0000115 "A type of fetal intraventricular hemorrhage that additionally includes hemorrhage in a large part of the periventricular parenchyma." ; dc:date "2022-04-10T12:32:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Grade IV fetal intracranial hemorrhage", "Grade IV foetal intracranial haemorrhage" ; a owl:Class ; rdfs:label "Fetal intraventricular hemorrhage with periventricular hemorrhage" ; rdfs:subClassOf obo:HP_0034210 . obo:HP_0034220 obo:IAO_0000115 "Expansion of the temporal lobes of the brain along all axes, including rostrocaudal, superoinferior, and mediolateral, resulting in a globular appearance of the brain." ; dc:date "2022-04-10T13:08:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Temporal lobe megalencephaly" ; rdfs:subClassOf obo:HP_0001355, obo:HP_0034221 . obo:HP_0034221 obo:IAO_0000115 "An abnormal strcutural of the zone (lobe) of the cerebral cortex that is located inferior to the lateral fissure on other cerebral hemispheres." ; dc:date "2022-04-10T13:13:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal temporal lobe morphology" ; rdfs:subClassOf obo:HP_0002538 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001871 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034222 obo:IAO_0000115 "A developmental defect of the temporal lobe of the cerebral cortex that is characterized by prominent sulcations and radially directed gyrations." ; dc:date "2022-04-10T13:16:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Temporal lobe dysplasia" ; rdfs:subClassOf obo:HP_0034221 . obo:HP_0034223 obo:IAO_0000115 "Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth." ; dc:date "2022-04-10T13:39:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated umbilical artery Dopplers", "Increased umbilical artery pulsatility index" ; a owl:Class ; rdfs:label "Elevated umbilical artery pulsatility" ; rdfs:subClassOf obo:HP_0025715 . obo:HP_0034224 obo:IAO_0000115 "An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an absence of flow in the umbilical artery at the end of diastole." ; dc:date "2022-04-10T13:42:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Abnormal umbilical artery Doppler velocimetry is correlated with a pathologic lesion of the placenta characterized by obliteration of arterioles in the tertiary stem villi; the umbilical artery flow velocity waveform is primarily determined by placental villous vascular architecture. The increased placental vascular resistance is reflected as a decreased diastolic phase of the umbilical artery waveform" ; rdfs:label "Absent end-diastolic umbilical artery flow" ; rdfs:subClassOf obo:HP_0025715 . obo:HP_0034225 obo:IAO_0000115 "An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow)." ; dc:date "2022-04-10T13:46:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reversed end-diastolic umbilical artery flow" ; rdfs:subClassOf obo:HP_0025715 . obo:HP_0034226 obo:IAO_0000115 "Characteristic appearance of the chest and abdomen in the sagittal view on prenatal ultrasound when the chest is small and the abdomen protruding." ; dc:date "2022-04-10T13:51:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 4E of PMID:31173381 and Figure 1B of PMID:23408600." ; rdfs:label "Champagne cork sign" ; rdfs:subClassOf obo:HP_0025662 . obo:HP_0034227 obo:IAO_0000115 "A type of aortic arch hypoplasia whereby the isthmus (arch between the left subclavian and insertion of the patent ductus arteriosus/ligamentum arteriosum) has a diameter of less than 40% of the diameter of the ascending aorta." ; dc:date "2022-04-10T14:00:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aortic isthmus hypoplasia" ; rdfs:subClassOf obo:HP_0012304 . obo:HP_0034228 obo:IAO_0000115 "A type of aortic arch hypoplasia whereby the proximal aortic arch (arch proximal to the origin of the left subclavian artery) has a diameter of less than 60% of the diameter of the ascending aorta." ; dc:date "2022-04-10T14:03:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Proximal aortic arch hypoplasia" ; rdfs:subClassOf obo:HP_0012304 . obo:HP_0034229 obo:IAO_0000115 "A type of aortic arch hypoplasia whereby the distal aortic arch (arch distal to the ductus arteriosus) has a diameter of less than 60% of the diameter of the ascending aorta." ; dc:date "2022-04-10T14:04:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Distal aortic arch hypoplasia" ; rdfs:subClassOf obo:HP_0012304 . obo:HP_0034230 obo:IAO_0000115 "A type of cross fused renal ectopia characterized by fusion between the upper pole of the cross-fused ectopic kidney (located more inferiorly relative to the other kidney) and the lower pole of the other orthotopic kidney (located in a more superior position)." ; dc:date "2022-04-10T14:14:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Type A cross fused renal ectopia" ; a owl:Class ; rdfs:label "Inferior crossed fused renal ectopia" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034231 obo:IAO_0000115 "A type of cross fused renal ectopia where the normal side kidney is present superiorly and the direction of pelvic is medial, the kidney which crosses positioned inferiorly with direction of pelvic toward the lateral side. As kidneys fuse after complete rotation on the vertical axis, both renal pelves lie in correct orientation." ; dc:date "2022-04-10T14:17:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "S-shaped kidney", "Type B cross fused renal ectopia" ; a owl:Class ; rdfs:comment "See Figure 2b of PMID:23599575." ; rdfs:label "Sigmoid kidney" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034232 obo:IAO_0000115 "A type of cross fused renal ectopia where fusion occurs over a wide margin, both renal pelves anteriorly directed and placed more inferiorly." ; dc:date "2022-04-10T14:23:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Type C cross fused renal ectopia" ; a owl:Class ; rdfs:label "Unilateral lump kidney" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034233 obo:IAO_0000115 "A type of cross fused renal ectopia in which kidneys fuse along their medial borders." ; dc:date "2022-04-10T14:26:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Type D cross fused renal ectopia" ; a owl:Class ; rdfs:label "Disc kidney" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034234 obo:IAO_0000115 "A type of cross fused renal ectopia in which the crossed kidney lies inferiorly and transversely, fused with the lower pole of the normal kidney." ; dc:date "2022-04-10T14:28:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Tandem kidney", "Type E cross fused renal ectopia" ; a owl:Class ; rdfs:label "L-shaped kidney" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034235 obo:IAO_0000115 "A type of cross fused renal ectopia in which the ectopic kidney lies superiorly and its lower pole fuses with the upper pole of the normal kidney. The renal pelvis of both kidneys lies anteriorly." ; dc:date "2022-04-10T14:29:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior crossed-fused renal ectopia" ; rdfs:subClassOf obo:HP_0004736 . obo:HP_0034236 obo:IAO_0000115 "Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation." ; dc:date "2022-04-10T14:32:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "AOP" ; a owl:Class ; rdfs:label "Apnea of prematurity" ; rdfs:subClassOf obo:HP_0002104 . obo:HP_0034237 obo:IAO_0000115 "A type of neural tube defect that is not covered by skin." ; dc:date "2022-04-10T17:29:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Open neural tube defect" ; rdfs:subClassOf obo:HP_0045005 . obo:HP_0034238 obo:IAO_0000115 "A type of neural tube defect that is covered by skin." ; dc:date "2022-04-10T17:33:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Closed neural tube defect" ; rdfs:subClassOf obo:HP_0045005 . obo:HP_0034239 obo:IAO_0000115 "The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output." ; dc:date "2022-04-10T17:38:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Diagnosis can be made by magnetic resonance angiography, Doppler ultrasonography, or computed tomography angiography." ; rdfs:label "Renal vein thrombosis" ; rdfs:subClassOf obo:HP_0033835 . obo:HP_0034240 obo:IAO_0000115 "An abnormal growth (lump) of tissue in the neck region of a fetus. Masses may be simple cystic,, cystic with a few simple septations (fewer than three septations and less than 3-mm thick), cystic with multiple or thick septations (greater than three septations or septations 3-mm-thick or more), a mass that is than is less than 50% solid, and a mass that is 50% solid or more." ; dc:date "2022-04-10T17:41:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal neck mass" ; rdfs:subClassOf obo:HP_0025667 . obo:HP_0034241 obo:IAO_0000115 "Death of a fetus in the uterus." ; dc:date "2022-04-10T17:51:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Death before birth", "Intrauterine death" ; a owl:Class ; rdfs:label "Prenatal death" ; rdfs:subClassOf obo:HP_0011420 . obo:HP_0034242 obo:IAO_0000115 "An anomalous structural finding of the fetal genitourinary system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dc:date "2022-04-10T18:07:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal genitourinary system morphology" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034243 obo:IAO_0000115 "An anomalous structural finding of the fetal lungs. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; dc:date "2022-04-10T18:08:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal fetal pulmonary morphology" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034244 obo:IAO_0000115 "At US examination from the second trimester onward, the fetal stomach appears as a uniformly anechoic, sharply circumscribed round structure in the left upper quadrant. However, debris is commonly visualized in the stomach, forming a pseudomass." ; dc:date "2022-04-10T18:56:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The origin of echogenic masses within the gastric lumen is incompletely understood. As they are seen in multiple planes, technical issues are unlikely. They may be due to swallowed cells that aggregate because of the relatively poor peristaltic activity in the stomach early in the second trimester. When intraamniotic bleeding has occurred, these pseudomasses are commonly visualized. They inevitably disappear during follow-up examinations and are not associated with an adverse neonatal outcome." ; rdfs:label "Gastric pseudomass" ; rdfs:subClassOf obo:HP_0034207 . obo:HP_0034245 dc:date "2022-04-10T18:58:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A structural anomaly in the fetal head region. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." ; rdfs:label "Fetal head anomaly" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034246 obo:IAO_0000115 "An abnormal growth (lump) of tissue that projects from the fetal scalp." ; dc:date "2022-04-10T18:59:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal scalp mass" ; rdfs:subClassOf obo:HP_0034245 . obo:HP_0034247 obo:IAO_0000115 "An obstruction in the ureter leading to bladder outlet obstruction. Special criteria are used for lower urinary tract obstruction (LUTO) in the fetus. Prenatal LUTO has classically been suspected on the basis of three ultrasonographic findings: megacystis, dilated posterior urethra (known as the keyhole sign) and hydronephrosis." ; dc:date "2022-04-10T19:18:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal lower urinary tract obstruction" ; rdfs:subClassOf obo:HP_0034242 . obo:HP_0034248 obo:IAO_0000115 "Increased echogenicity (increased brightness in the gray-scale sonography image) of the lens of a fetus." ; dc:date "2022-04-10T19:22:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Both the normal fetal lens and vitreous appear hypoechoic by ultrasound. On endovaginal ultrasound, the fetal lens may be visualized as early as 14 weeks of gestational age. The outline of the lens may be visible as a thin, echogenic line in the anterior aspect of the globe; however, the lens may be difficult to see depending on the angle of the insonation beam relative to the lens position. Increased echogenicity of the fetal lens can be observed with some forms of developmental cataract." ; rdfs:label "Increased fetal lens echogenicity" ; rdfs:subClassOf obo:HP_0034058 . obo:HP_0034249 obo:IAO_0000115 "An unusually severe infection by an influenza virus." ; dc:date "2022-04-12T22:52:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe influenza infection" ; rdfs:subClassOf obo:HP_0031691 . obo:HP_0034250 obo:IAO_0000115 "Nuchal edema is considered present in a fetus at gestational week 14 or more if in the midsagittal plane of the neck, there is subcutaneous edema that produces a characteristic tremor on ballotment of the fetal head. This constitutes the severe end of the spectrum of increased nuchal fold thickness, which is defined as soft-tissue thickening of 6 mm or more, seen in the suboccipitobregmatic view of the fetal head. Nuchal edema may be confined to the neck or it may be generalized, as part of hydrops fetalis." ; dc:date "2022-04-12T22:57:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In the fetus fluid collects behind the neck, much like it does in dependent ankle oedema in later life. This occurs partly because of the tendency for the fetus to lie on its back and partly because of the laxity of the skin of the neck. As with ankle oedema this accumulation of fluid can represent the end point of several pathological processes, including heart failure. Fluid collecting behind the neck can be detected as nuchal translucency by ultrasound scanning, and it can be measured. The more fluid that has accumulated, the greater the risk of an abnormality being present." ; rdfs:label "Fetal nuchal edema" ; rdfs:subClassOf obo:HP_0025667 . obo:HP_0034251 obo:IAO_0000115 "An anomaly of the corneal reflex that normally induces involuntary blinking of the eyelids following contact of the cornea." ; dc:date "2022-04-23T11:42:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The corneal reflex can be tested by touching the cornea lightly with a cotton tip. The normal response to to blink (shut the eyelids) immediately. To evaluate the corneal reflex, the examiner uses a cotton-tipped applicator, the tip of which has been pulled into a thin strand. The examiner stabilizes the patient's head by placing a hand on the patient's eyebrow and head. The patient is asked to look to the left side as the cotton tip is brought in from the right side to touch the right cornea gently." ; rdfs:label "Abnormal corneal reflex" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0034252 obo:IAO_0000115 "Absence of the corneal blinking reflex, which normally induces involuntary blinking of the eyelids following contact of the cornea. The corneal blink reflex is caused by a loop between the trigeminal sensory nerves and the facial motor (VII) nerve innervation of the orbicularis oculi muscles." ; dc:date "2022-04-23T11:43:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent corneal reflex" ; rdfs:subClassOf obo:HP_0034251 . obo:HP_0034253 obo:IAO_0000115 "An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes." ; dc:date "2022-04-23T11:47:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Eosinophil nuclear hypersegmentation" ; rdfs:subClassOf obo:HP_0001879 . obo:HP_0034254 obo:IAO_0000115 "The face of the giant panda sign on T2-weighted MRI is characterized by preservation of normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, high signal in the tegmentum, and hypointensity of the superior colliculus. The findings are said to resemble the face of a giant panda." ; dc:date "2022-05-07T14:24:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Midbrain panda sign" ; a owl:Class ; rdfs:comment "See Figure b of PMID:14557570." ; rdfs:label "Face of the giant panda sign" ; rdfs:subClassOf obo:HP_0002418 . obo:HP_0034255 obo:IAO_0000115 "An aberrant, pathological communication between the colon and the bladder." ; dc:date "2022-05-07T14:27:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Colovesicular fistula", "Vesicocolic fistula" ; a owl:Class ; rdfs:comment "The most common cause of colovesicular fistulas is the sequelae of complicated diverticulitis and accounts for over two-thirds of cases. The second most common cause is a malignancy in 10% to 20% of cases and is usually adenocarcinoma of the colon. Crohn's colitis is the third most common cause (5% to 7% of cases) and usually is a result of long-standing disease." ; rdfs:label "Colovesical fistula" ; rdfs:subClassOf obo:HP_0004321, obo:HP_0100819 . obo:HP_0034256 obo:IAO_0000115 "Lack of demonstrable hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin." ; dc:date "2022-05-11T12:26:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent dermoepidermal hemidesmosomes" ; rdfs:subClassOf obo:HP_0032449 . obo:HP_0034257 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that recognize C4b2a, the C3 convertase of the classical pathway of complement." ; dc:date "2022-05-11T12:59:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "C4 nephritic factor positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_0034258 obo:IAO_0000115 "Absence or underdevelopment of the midbrain (mesencephalon)." ; dc:date "2022-05-21T15:34:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aplasia/Hypoplasia of the mesencephalon" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the midbrain" ; rdfs:subClassOf obo:HP_0002418 . obo:HP_0034259 obo:IAO_0000115 "A developmental defect characterized by underdevelopment of the mesencephalon." ; dc:date "2022-05-21T15:34:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoplasia of the mesencephalon", "Hypoplastic mesencephalon" ; a owl:Class ; rdfs:label "Hypoplasia of the midbrain" ; rdfs:subClassOf obo:HP_0034258 . obo:HP_0034260 obo:IAO_0000115 "Developmental defect characterized by the absence of the zygomatic arch." ; dc:date "2022-05-21T15:43:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplastic zygomatic arch" ; rdfs:subClassOf obo:HP_0005557 . obo:HP_0034261 obo:IAO_0000115 "A developmental defect characterized by absence or underdevelopment of one or more facial bone." ; dc:date "2022-05-21T15:47:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of facial bones" ; rdfs:subClassOf obo:HP_0011821 . obo:HP_0034262 obo:IAO_0000115 "Lack of development of lanugo, the fine, soft, unpigmented hair on the body of a fetus or newborn baby." ; dc:date "2022-05-21T15:48:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lanugo arises about three months into development and plays an essential role in binding the vernix caseosa to the skin of fetuses." ; rdfs:label "Absent lanugo" ; rdfs:subClassOf obo:HP_0025723 . obo:HP_0034263 obo:IAO_0000115 "Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal." ; dc:date "2022-05-21T15:50:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vaginal bleeding" ; rdfs:subClassOf obo:HP_0001892, obo:HP_0034268 . obo:HP_0034264 obo:IAO_0000115 "Postcoital bleeding (PCB) consists of spotting or bleeding after sexual intercourse that is not related to a person's menstrual cycle." ; dc:date "2022-05-21T15:51:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bleeding after sex" ; a owl:Class ; rdfs:label "Postcoital vaginal bleeding" ; rdfs:subClassOf obo:HP_0034263 . obo:HP_0034265 obo:IAO_0000115 "Pain in the breast." ; dc:date "2022-05-21T15:55:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Breast pain", "Painful breast" ; a owl:Class ; rdfs:label "Mastalgia" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0034266 obo:IAO_0000115 "Bleeding during sex." ; dc:date "2022-05-21T15:57:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vaginal bleeding during sex" ; rdfs:subClassOf obo:HP_0034263 . obo:HP_0034267 obo:IAO_0000115 "Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones." ; dc:date "2022-05-21T15:58:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pain in the pelvis" ; a owl:Class ; rdfs:label "Pelvic pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0034268 obo:IAO_0000115 "Any anomaly of vagina function." ; dc:date "2022-05-21T16:01:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vaginal physiology" ; rdfs:subClassOf obo:HP_0030012 . obo:HP_0034269 obo:IAO_0000115 "Anomalous amount, odor, or consistency of the fluid or mucus that comes from the vagina" ; dc:date "2022-05-21T16:04:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal vaginal discharge" ; rdfs:subClassOf obo:HP_0034268 . obo:HP_0034270 obo:IAO_0000115 "Incisor teeth with irregular edges said to resemble a saw." ; dc:date "2022-05-21T16:09:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Jagged incisors" ; a owl:Class ; rdfs:label "Serrated incisors" ; rdfs:subClassOf obo:HP_0011063 . obo:HP_0034271 obo:IAO_0000115 "Diffuse prominent gyral impressions on the inner table of skull vault said to resemble beaten copper." ; dc:date "2022-05-21T16:17:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Copper beaten skull" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0034272 obo:IAO_0000115 "Decreased amount of autofluorescence (emission of fluorescent light from ocular structures in the absence of sodium fluorescein) in the retina in the region surrounding the fovea." ; dc:date "2022-05-21T16:20:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fundus autofluorescence utilizes a scanning laser ophthalmoscope to stimulate intrinsically autofluorescent molecules of lipofuscin to visualize the retinal pigment epithelium." ; rdfs:label "Perifoveal hypoautofluorescence" ; rdfs:subClassOf obo:HP_0025159 . obo:HP_0034273 obo:IAO_0000115 "Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation." ; dc:date "2022-05-22T12:50:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Premature facial sagging" ; a owl:Class ; rdfs:label "Premature sagging cheeks" ; rdfs:subClassOf obo:HP_0004426 . obo:HP_0034274 obo:IAO_0000115 "A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae." ; dc:date "2022-05-22T14:16:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Gastrointestinal ulcers result from the tissue necrosis triggered by mucosal ischemia, ree radical formation and cessation of nutrient delivery, all caused by vascular and microvascular injury such as thrombi, constriction, or other occlusion." ; rdfs:label "Gastrointestinal ulcer" ; rdfs:subClassOf obo:HP_0012718 . obo:HP_0034275 obo:IAO_0000115 "A type of epidermal nevus (which represent Blaschkoid hamartomas of the skin that result from mosaic post-zygotic mutations) that appears as skin-colored-to-brown, sharply demarcated, papillomatous papules that coalesce into plaques. The majority of these nevi are either present at birth or occur within the first year of life." ; dc:date "2022-05-22T14:21:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Verrucous epidermal nevus" ; rdfs:subClassOf obo:HP_0010816 . obo:HP_0034276 obo:IAO_0000115 "Concentration of thymidine in the blood circulation above the normal range." ; dc:date "2022-05-28T21:37:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased serum thymidine" ; a owl:Class ; rdfs:label "Elevated circulating thymidine concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0034277 obo:IAO_0000115 "Concentration of 2-deoxyuridine in the blood circulation is above the normal range." ; dc:date "2022-05-28T21:43:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating deoxyuridine concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0034278 obo:IAO_0000115 "Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis." ; dc:date "2022-05-28T21:45:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone marrow: multinucleated erythroblasts", "Multinucleate erythroblast" ; oboInOwl:hasRelatedSynonym "Binucleated erythroblast", "Double-nucleated erythroblast" ; a owl:Class ; rdfs:label "Multinucleated erythroblast" ; rdfs:subClassOf obo:HP_0012130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001908 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000765 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034279 obo:IAO_0000115 "The presence of 2,8-dihydroxyadenine crystals in the urine. The crystals appear as round, yellow-brown crystals." ; dc:date "2022-05-28T21:54:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2,8-dihydroxyadenine urinary crystals" ; a owl:Class ; rdfs:label "2,8-dihydroxyadenine crystalluria" ; rdfs:subClassOf obo:HP_0020074 . obo:HP_0034280 obo:IAO_0000115 "Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target." ; dc:date "2022-05-28T21:56:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Codocytes" ; a owl:Class ; rdfs:label "Target cells" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0034281 obo:IAO_0000115 "Cone-shaped epiphyses of the phalanges of the hands or feet. Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery." ; dc:date "2022-05-28T22:15:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cone-shaped epiphyses of phalanges", "Cone-shaped phalangeal epiphyses" ; a owl:Class ; rdfs:label "Phalangeal cone-shaped epiphyses" ; rdfs:subClassOf obo:HP_0010579 . obo:HP_0034282 obo:IAO_0000115 "Formation of abnormal, extraskeletal bony tissue in the soft tissue beneath the skin. Subcutaneous ossifications may be observed by radiography or by palpation." ; dc:date "2022-06-04T14:41:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See the Figure in PMID:29059381." ; rdfs:label "Subcutaneous ossification" ; rdfs:subClassOf obo:HP_0011986 . obo:HP_0034283 obo:IAO_0000115 "Abnormally high concentration of protoporphyrin (derivative of porphyrin with propionic acid groups) in feces." ; dc:date "2022-06-04T14:44:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased fecal protoporphyrin concentration" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034284 obo:IAO_0000115 "Repeated occurrences of inflammatory condition of the gums (gingival tissue), most commonly caused by bacterial infection." ; dc:date "2022-06-04T14:47:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Recurrent gingivitis" ; rdfs:subClassOf obo:HP_0002719 . obo:HP_0034285 obo:IAO_0000115 "Inflamation of the brain related to infection by an enterovirus." ; dc:date "2022-06-04T14:49:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Enteroviral encephalitis" ; rdfs:subClassOf obo:HP_0033993 . obo:HP_0034286 obo:IAO_0000115 "Pneumocystis carinii pneumonia is an opportunistic infection that occurs in immunosuppressed populations." ; dc:date "2022-06-04T14:51:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pneumocystis carinii pneumonia" ; rdfs:subClassOf obo:HP_0032255 . obo:HP_0034287 obo:IAO_0000115 "Lack of detectable fibrinogen in the blood circulation." ; dc:date "2022-06-04T14:53:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Afibrinogenemia" ; rdfs:subClassOf obo:HP_0011898 . obo:HP_0034288 obo:IAO_0000115 "Abnormally increased concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation." ; dc:date "2022-06-26T21:04:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating reverse triiodothyronine concentration", "Elevated rT3" ; a owl:Class ; rdfs:comment "Reverse T3 is the third most abundant iodothyronine circulating in human blood and is produced by the inner ring deiodination of the pro-hormone thyroxine (T4). The number 4 in T4 means it has 4 iodine atoms. It can lose 1 of them, yielding either T3 or reverse T3, depending on which iodine atom it loses. Loss of iodine from the five-prime position on its outer ring yields T3, the most potent thyroid hormone. On the other hand, when T4 loses an iodine atom from the five position on its inner ring it yields reverse T3. Reverse T3 is inactive." ; rdfs:label "Elevated circulating reverse T3 concentration" ; rdfs:subClassOf obo:HP_0031508 . obo:HP_0034289 obo:IAO_0000115 "An abnormally increased ratio of the concentrations of reverse T3 to T3 in the blood circulation." ; dc:date "2022-06-26T21:08:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating rT3/T3 ratio" ; rdfs:subClassOf obo:HP_0031508 . obo:HP_0034290 obo:IAO_0000115 "Concentration of tiglylglycine in the blood circulation above the upper limit of normal." ; dc:date "2022-07-03T13:57:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating tiglylglycine concentration" ; rdfs:subClassOf obo:HP_0004354 . obo:HP_0034291 obo:IAO_0000115 "An elevation above the normal range of creatine in the blood circulation." ; dc:date "2022-06-26T21:42:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating creatine concentration" ; rdfs:subClassOf obo:HP_0012113 . obo:HP_0034292 obo:IAO_0000115 "An reduction below the normal range of creatine in the blood circulation." ; dc:date "2022-06-26T21:43:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating creatine concentration" ; rdfs:subClassOf obo:HP_0012113 . obo:HP_0034293 obo:IAO_0000115 "The presence of calcium deposition within the temporal lobe of the brain." ; dc:date "2022-06-26T21:44:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Temporal lobe calcification" ; rdfs:subClassOf obo:HP_0002514 . obo:HP_0034294 obo:IAO_0000115 "Bile thrombi that form an obstruction (plug) in a dilated bile duct." ; dc:date "2022-06-26T21:48:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ductal bile plugs" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0034295 obo:IAO_0000115 "An abnormally low volume of the white matter of the brain." ; dc:date "2022-07-03T14:04:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "White matter loss" ; a owl:Class ; rdfs:comment "This feature can be ascertained by modalities including segmented volumetric magnetic resonance imaging. Reduced white matter volume may manifest as sulcal deepening and widening, enlarged ventricles, and an increased ratio of cerebrospinal fluid to gray and white matter." ; rdfs:label "Reduced cerebral white matter volume" ; rdfs:subClassOf obo:HP_0002500 . obo:HP_0034296 obo:IAO_0000115 "Detection of 3,5,6-trichloro-2-pyridinol in the urine." ; dc:date "2022-07-03T14:10:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "3,5,6-trichloro-2-pyridinol is a metabolite produced following exposure to chlorpyrifos, an organophosphate insecticide." ; rdfs:label "Elevated urine 3,5,6-trichloro-2-pyridinol level" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0034297 obo:IAO_0000115 "Elevated concentration of tetracosanoic acid (a C24 straight-chain saturated fatty acid) in the blood circulation." ; dc:date "2022-07-03T14:21:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating tetracosanoic acid concentration" ; rdfs:subClassOf obo:HP_0010966 . obo:HP_0034298 obo:IAO_0000115 "Elevated concentration of hexacosanoic acid (a C26 straight-chain saturated fatty acid) in the blood circulation." ; dc:date "2022-07-03T14:22:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating cerotic acid concentration" ; a owl:Class ; rdfs:label "Elevated circulating hexacosanoic acid concentration" ; rdfs:subClassOf obo:HP_0010966 . obo:HP_0034299 obo:IAO_0000115 "A histological phenotype observed on testicular biopsy in which only Sertoli cells line the seminiferous tubules of the testis." ; dc:date "2022-07-03T14:24:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sertoli cells are found in the convoluted seminiferous tubules and form part of the blood-testis barrier in males. With Sertoli cell-only phenotype, spermatogenic cells, which are normally located in between the Seroli cells, are absent." ; rdfs:label "Sertoli cell-only phenotype" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0034300 obo:IAO_0000115 "Reduced activity of the enzyme acid sphingomyelinase activity in the blood circulation." ; dc:date "2022-07-03T14:30:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased acid sphingomyelinase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034301 obo:IAO_0000115 "A malformation of the colon in which a pouch-like dilatation of a varying degree of shortened colon is associated with an anorectal malformation. The pouch usually terminates in a fistulous communication with the genitourinary tract." ; dc:date "2022-07-03T14:33:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Congenital pouch colon" ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0034302 obo:IAO_0000115 "A congenitally anomalous enlarged optic disk (surface area greater than 2.50 square millimeters). It is considered to be a normal variant without physiological defects." ; dc:date "2022-07-03T14:38:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Megalopapilla" ; rdfs:subClassOf obo:HP_0012795 . obo:HP_0034303 obo:IAO_0000115 "A bifid T-wave with a notch duration between the 2 peaks at leasy 0.04 sec and an amplitude at least 0.05 mV." ; dc:date "2022-07-10T12:28:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Notched T-wave" ; a owl:Class ; rdfs:label "Notched T wave" ; rdfs:subClassOf obo:HP_0005135 . obo:HP_0034304 obo:IAO_0000115 "An electric signal of depolarization observed between the end of the QRS complex and the beginning of the T wave." ; dc:date "2022-07-10T12:29:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In arrhythmogenic cardiomyopathy, the epsilon wave is found in the right precordial leads, where the QRS complex is broader than in the left precordial leads with a difference of at least 25 milliseconds." ; rdfs:label "Epsilon wave" ; rdfs:subClassOf obo:HP_0003115 . obo:HP_0034305 obo:IAO_0000115 "A type of second-degree atrioventricular block in which every other P wave is not conducted through the AV node such that only every other P wave is followed by a QRS complex." ; dc:date "2022-07-10T12:32:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2:1 AV block" ; a owl:Class ; rdfs:label "2:1 atrioventricular block" ; rdfs:subClassOf obo:HP_0011706 . obo:HP_0034306 obo:IAO_0000115 "An electrocardiographic finding of a normal QRS followed by a premature ventricular contraction; a rhythmic pairing of normal and atypical beats originating in the ventricles in a 1-1 ratio such that an ectopic ventricular beat follows each regular heartbeat." ; dc:date "2022-07-10T12:36:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ventricular bigeminy" ; rdfs:subClassOf obo:HP_0004308 . obo:HP_0034307 obo:IAO_0000115 "The LV end-diastolic internal diameter was measured from two-dimensional (2D) images in the parasternal long-axis view, timed with mitral valve closure at the level of the mitral valve chordae." ; dc:date "2022-07-10T13:09:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated left ventricular end-diastolic diameter" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0034308 obo:IAO_0000115 "Abnormal increased in the duration of the P wave, which is a marker of delayed inter-atrial conduction." ; dc:date "2022-08-07T12:58:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Prolonged P wave duration has been associated with atrial fibrillation and with increased all-cause, cardiovascular disease and stroke mortality. Various cut off values have been suggested for prolonged P wave duration, generally between 110 ms or 120 ms." ; rdfs:label "Prolonged P wave" ; rdfs:subClassOf obo:HP_0031595 . obo:HP_0034309 obo:IAO_0000115 "Spermatozoa with multiple flagella attached to the sperm head." ; dc:date "2022-08-07T13:31:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multi-tailed spermatozoa" ; a owl:Class ; rdfs:label "Multiflagellar spermatozoa" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0034310 obo:IAO_0000115 "Infection with the yellow fever virus of the live-attenuated vaccine." ; dc:date "2022-08-07T13:33:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Postvaccination yellow fever" ; a owl:Class ; rdfs:label "Post-vaccination yellow fever" ; rdfs:subClassOf obo:HP_0020085 . obo:HP_0034311 obo:IAO_0000115 "Developmental defect characterized by undergrowth of the optic chiasm." ; dc:date "2022-08-07T13:35:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Optic chiasm hypoplasia" ; a owl:Class ; rdfs:label "Hypoplastic optic chiasm" ; rdfs:subClassOf obo:HP_0025163 . obo:HP_0034312 obo:IAO_0000115 "Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent." ; dc:date "2022-08-13T14:35:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sleep hypoxemia", "Sleep-related hypoxemia" ; a owl:Class ; rdfs:label "Nocturnal hypoxemia" ; rdfs:subClassOf obo:HP_0012418 . obo:HP_0034313 obo:IAO_0000115 "An abnoramlly increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent." ; dc:date "2022-08-13T14:39:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hyperdynamic left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0034314 . obo:HP_0034314 obo:IAO_0000115 "Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent." ; dc:date "2022-08-13T14:40:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal left ventricular ejection fraction" ; rdfs:subClassOf obo:HP_0005162 . obo:HP_0034315 obo:IAO_0000115 "A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children." ; dc:date "2022-08-13T15:01:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Chronic cough" ; rdfs:subClassOf obo:HP_0012735 . obo:HP_0034316 obo:IAO_0000115 "Reduced volume of pars compacta of the substantia nigra." ; dc:date "2022-08-14T10:22:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta." ; rdfs:label "Thinning of the substantia nigra pars compacta" ; rdfs:subClassOf obo:HP_0045007 . obo:HP_0034317 dc:date "2022-08-14T11:58:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An unusual virus infection that is regarded as a sign of a pathological susceptibility to infection by a virus." ; rdfs:label "Unusual viral infection" ; rdfs:subClassOf obo:HP_0032101 . obo:HP_0034318 obo:IAO_0000115 "Reactivation is the mechanism whereby a latent virus that has infected a host cell switches to a lytic stage, undergoing productive viral replication and allowing the virus to spread. This term refers to reactivation regarded as unusual because of frequency, intensity, location, or nature of the virus, in the sense that the reactivation would not be observed in an immunocompetent host." ; dc:date "2022-08-14T12:00:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Unusual virus reactivation" ; rdfs:subClassOf obo:HP_0034317 . obo:HP_0034319 obo:IAO_0000115 "A vasculopathy in the central nervous system (CNS) following reactivation of varicella-zoster virus due to a productive viral infection of both large and small cerebral arteries." ; dc:date "2022-08-14T12:07:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "CNS vasculitis with reactivation of varicella-zoster virus" ; rdfs:subClassOf obo:HP_0034318 . obo:HP_0034320 obo:IAO_0000115 "Intracytoplasmic inclusions in myofibers that reduce nitro-blue tetrazolium (NBT) and thus stain strongly with the menadione-NBT stain." ; dc:date "2022-08-17T14:26:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intracytoplasmic myofiber reducing inclusion bodies" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:18274675." ; rdfs:label "Muscle fiber intracytoplasmic reducing inclusion bodies" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0034321 obo:IAO_0000115 "Concentration of guanidinoacetic acid in the blood circulation is above the upper limit of normal." ; dc:date "2022-08-17T14:30:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating guanidinoacetic acid concentration" ; a owl:Class ; rdfs:label "Elevated circulating guanidinoacetic acid concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0034322 obo:IAO_0000115 "Diminished enzyme activity of galactocerebrosidase." ; dc:date "2022-08-17T14:32:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Reduced galactocerebrosidase activity is a feature of Krabbe disease." ; rdfs:label "Reduced galactocerebrosidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034323 obo:IAO_0000115 "Concentration of growth hormone in the blood circulation below normal limits." ; dc:date "2022-08-17T16:18:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating growth hormone concentration" ; rdfs:subClassOf obo:HP_0032367 . obo:HP_0034324 obo:IAO_0000115 "An abnormal widening (dilatation) of the brachiocephalic artery" ; dc:date "2022-08-17T17:31:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dilatated brachiocephalic artery", "Innominate artery aneurysm" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:33743755." ; rdfs:label "Brachiocephalic artery aneurysm" ; rdfs:subClassOf obo:HP_0002617 . obo:HP_0034325 obo:IAO_0000115 "An abnormal widening (dilatation) of the common carotid artery." ; dc:date "2022-08-17T17:35:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Common carotid artery aneurysm" ; rdfs:subClassOf obo:HP_0430021 . obo:HP_0034326 obo:IAO_0000115 "Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding." ; dc:date "2022-08-17T22:34:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Adenomyosis" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0034327 obo:IAO_0000115 "Thin, punctiform elements of various colors in the posterior stroma of the cornea, immediately anterior to Descemet membrane. The elements are visible to direct and indirect illumination." ; dc:date "2022-08-17T22:44:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Punctiform multicolored opacities in the posterior corneal stroma", "Punctiform multicoloured opacities in the posterior corneal stroma" ; a owl:Class ; rdfs:label "Posterior corneal stroma punctiform multicolored opacities" ; rdfs:subClassOf obo:HP_0011492 . obo:HP_0034328 obo:IAO_0000115 "A condition in which the lumen of a bile duct has been filled by fibrous scar material, in effect replacing the bile duct with a fibrous scar." ; dc:date "2022-08-17T23:05:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fibro-obliterative bile-duct scarring", "Fibro-obliterative loss of bile ducts" ; a owl:Class ; rdfs:comment "See Figure 3 in PMID:18701947." ; rdfs:label "Fibro-obliterative bile-duct lesion" ; rdfs:subClassOf obo:HP_0011040 . obo:HP_0034329 obo:IAO_0000115 "A congenital brain malformation characterized by marked overgrowth and dysplasia affecting one or both cerebral hemispheres, and, in some cases, subcortical brain regions as well. The presence of dysplasia in dysplastic megalencephaly distinguishes it from other forms of generalized megalencephaly." ; dc:date "2022-08-20T13:16:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bilateral hemimegalencephaly" ; a owl:Class ; rdfs:label "Dysplastic megalencephaly" ; rdfs:subClassOf obo:HP_0001355 . obo:HP_0034330 obo:IAO_0000115 "Decreased range of right ventricular motion in a portion of the right ventricle of the heart." ; dc:date "2022-08-20T13:37:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Regional right ventricular hypokinesis" ; rdfs:subClassOf obo:HP_0033118 . obo:HP_0034331 obo:IAO_0000115 "Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle." ; dc:date "2022-08-20T13:41:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A positive McConnell sign may be observed in patients with pulmonary embolism or right ventricular infarction." ; rdfs:label "McConnell sign" ; rdfs:subClassOf obo:HP_0034330 . obo:HP_0034332 obo:IAO_0000115 "Loss of cognitive developmental skills, as manifested by loss of developmental cognitive milestones." ; dc:date "2022-08-20T14:07:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cognitive regression" ; rdfs:subClassOf obo:HP_0002376 . obo:HP_0034333 obo:IAO_0000115 "Elevated concentration of hypoxanthine in the blood circulation." ; dc:date "2022-08-20T14:13:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoxanthine high in blood" ; a owl:Class ; rdfs:label "Increased circulating hypoxanthine concentration" ; rdfs:subClassOf obo:HP_0004368 . obo:HP_0034334 dc:date "2022-09-04T11:14:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "allelic_requirement" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . obo:HP_0034335 obo:IAO_0000115 "The terms in this hierarchy can be used to specificy the context in which inheritance of a disease is typically observed." ; dc:date "2022-09-04T11:54:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Inheritance modifier" ; a owl:Class ; rdfs:label "Inheritance qualifier" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0034336 obo:IAO_0000115 "Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion." ; dc:date "2022-09-04T12:24:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spleen infarct", "Spleen infarction", "Splenic infarct" ; a owl:Class ; rdfs:comment "Splenic infarction may be global or involve a segment of the spleen depending on which vessel is occluded. Typical presentation includes left sided abdominal pain in a person with an underlying hematologic disorder, hypercoagulable state, blood-borne malignancy, blunt abdominal trauma, or embolic illness." ; rdfs:label "Splenic infarction" ; rdfs:subClassOf obo:HP_0025408 . obo:HP_0034337 obo:IAO_0000115 "An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw." ; dc:date "2022-09-04T12:25:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anything that may lead to ulnar nerve palsy can cause claw hand. Ulnar nerve palsy can arise from a laceration anywhere along its course. Proximal injuries to the medial cord of the brachial plexus may also present with sensory loss distally. Ulnar nerve palsies can also be due to cubital tunnel syndrome and ulnar tunnel syndrome. These are compression neuropathies at the elbow and wrist. Another cause of ulnar nerve palsy may be a failure to splint the hand in an intrinsic-plus posture following a crush injury. There are a few systemic diseases that may also lead to ulnar nerve palsy. These include leprosy, syringomyelia, and Charcot-Marie-Tooth disease." ; rdfs:label "Claw hand deformity" ; rdfs:subClassOf obo:HP_0009473 . obo:HP_0034338 obo:IAO_0000115 "Requires that the abnormal allele be paternal or maternal in origin, depending on the disease-gene relationship. Imprinting refers to a normal developmental process in which either the paternal or maternal allele is inactivated, depending on the specific locus, thus leading to expression from only one copy of the gene. Disease typically manifests when a deleterious variant is inherited from a parent whose copy of the gene would normally be expressed, but not when a deleterious variant is inherited from a parent whose copy of the gene would normally be inactivated." ; dc:date "2022-09-04T13:13:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Imprinting disorders can be caused by a variety of mutational mechanisms (including copy number variants, nucleotide variants, and abnormal imprinting patterns) thus requiring some care when designing analytic pipelines." ; rdfs:label "Imprinted" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0034339 obo:IAO_0000115 "A pattern of inheritance observed for alleles in the X-Y identical regions is referred to as pseudoautosomal inheritance, because it resembles the pattern seen for alleles located on autosomes." ; dc:date "2022-09-04T13:22:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pseudoautosomal region inheritance" ; a owl:Class ; rdfs:comment "The pseudoautosomal regions (PAR1 and PAR2) are short regions of homology between the mammalian X and Y chromosomes. The PAR behave like an autosome and recombine during meiosis. Thus genes in this region are inherited in an autosomal rather than a strictly sex-linked fashion." ; rdfs:label "Pseudoautosomal inheritance" ; rdfs:subClassOf obo:HP_0034345 . obo:HP_0034340 obo:IAO_0000115 "A type of pseudoautosomal inheritance that is dominant and in which heterozygous males and females both manifest a disease phenotype." ; dc:date "2022-09-04T13:30:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "monoallelic_PAR" ; a owl:Class ; rdfs:label "Pseudoautosomal dominant inheritance" ; rdfs:subClassOf obo:HP_0034339 . obo:HP_0034341 obo:IAO_0000115 "A type of pseudoautosomal inheritance that is recessive and in which biallelic males and females both manifest a disease phenotype." ; dc:date "2022-09-04T13:36:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "biallelic_PAR" ; a owl:Class ; rdfs:label "Pseudoautosomal recessive inheritance" ; rdfs:subClassOf obo:HP_0034339 . obo:HP_0034342 obo:IAO_0000115 "A developmental defect characterized by lack of formation of the trapezius muscle, which is broad superficial muscle that extends from the posterior neck to the posterior part of the trunk (thorax)." ; dc:date "2022-09-04T13:46:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Trapezius muscle aplasia" ; rdfs:subClassOf obo:HP_0011006 . obo:HP_0034343 obo:IAO_0000115 "A rarely encountered phenomenon in which condition is most severe in the heterozygous state. Such disorders are rare and currently all are X-linked. Most X-linked recessive conditions manifest if hemizygous in males, or biallelic in females, though may have a mild phenotype in the heterozygous state in females." ; dc:date "2022-09-04T13:51:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Craniofrontonasal dysplasia due to EFNB1 and PCDH19-related epilepsy are both X-linked recessive and paradoxically more severe in females. Hemizygous males may be mildly affected but seldom manifest the full phenotype. Importantly the mutant allele can be inherited from a normal or very mildly affected father. The mechanism is currently accepted to be due to cellular interference whereby the two distinct cell populations (those with and without the variant) exhibit abnormal cellular interactions in the mosaic state - in women, who are functionally mosaic due to random X inactivation, or mosaic males. The same mechanism could theoretically be applicable to autosomal genes with a mosaic variant." ; rdfs:label "Requires heterozygosity" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0034344 obo:IAO_0000115 "Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the female sex." ; dc:date "2022-09-04T14:10:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Female-limited expression" ; rdfs:subClassOf obo:HP_0001470 . obo:HP_0034345 obo:IAO_0000115 "A mode of inheritance of diseases whose pathophysiology can be traced back to deleterious variants in a single gene. The inheritance patterns of these single-gene (monogenic) diseases are often referred to as Mendelian in honor of Gregor Mendel." ; dc:date "2022-09-04T14:25:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mendelian, or monogenic, inheritance of human diseases refers to patterns of transmission of recognizable disease entities. In many cases variability of clinical manifestations is observed and may be related to variation in other genes, environmental factors, or other unknown causes." ; rdfs:label "Mendelian inheritance" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0034346 obo:IAO_0000115 "An abnormality of pancreatic beta cells characterized by a proliferation of abnormal beta cells throughout the entire pancreas, with enlarged islet size and number (hypertrophic islets), increased periductular islets, enlarged beta-cell nuclei and abundant clear cytoplasm. Occasionally beta cells with pleomorphic nuclei, ductuloinsular complexes, and neoformation of islets from ducts are observed." ; dc:date "2022-09-04T14:58:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nesidioblastosis" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0034347 obo:IAO_0000115 "Increase in thickness of the great auricular nerve, a cutaneous nerve of the head. It originates from the cervical plexus, with branches of spinal nerves C2 and C3. Thickening may lead to the nerve being palpable or even visible in this region." ; dc:date "2022-09-04T15:00:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Palpable great auricular nerve" ; a owl:Class ; rdfs:label "Greater auricular nerve thickening" ; rdfs:subClassOf obo:HP_3000048 . obo:HP_0034348 obo:IAO_0000115 "A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately below the pulmonary valve." ; dc:date "2022-09-04T15:46:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Infundibular pulmonary stenosis", "Infundibular pulmonic stenosis", "Subvalvar pulmonary stenosis", "Subvalvar pulmonic stenosis", "Subvalvular pulmonary stenosis", "Subvalvular pulmonic stenosis" ; a owl:Class ; rdfs:label "Subpulmonary stenosis" ; rdfs:subClassOf obo:HP_0001642 . obo:HP_0034349 obo:IAO_0000115 "A cardiovascular malformation associated with narrowing at the level of the pulmonary sinotubular junction above the pulmonic valve." ; dc:date "2022-09-04T15:52:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Supravalvar pulmonnic stenosis", "Supravalvular pulmonary stenosis", "Supravalvular pulmonic stenosis" ; a owl:Class ; rdfs:label "Supravalvar pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001642 . obo:HP_0034350 obo:IAO_0000115 "A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately at the level of the pulmonary valve." ; dc:date "2022-09-04T15:53:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Valvular pulmonary stenosis" ; rdfs:subClassOf obo:HP_0001642 . obo:HP_0034351 obo:IAO_0000115 "Peripheral nerve hyperexcitability manifesting as spontaneous discharges originating from motor axons or their terminals, lead to overactivity of muscles, typically manifesting as twitches, cramps and stiffness." ; dc:date "2022-09-04T15:57:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peripheral nerve hyperexcitability" ; a owl:Class ; rdfs:label "Neuromyotonia" ; rdfs:subClassOf obo:HP_0032120 . obo:HP_0034352 obo:IAO_0000115 "An elevated growth from the the mucosa of the bile duct." ; dc:date "2022-09-04T18:28:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bile duct polyp" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0034353 obo:IAO_0000115 "A type of spasticity that affects one or more limbs (arms or legs)." ; dc:date "2022-09-04T18:49:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Appendicular spasticity" ; rdfs:subClassOf obo:HP_0001257 . obo:HP_0034354 obo:IAO_0000115 "Transverse fractures through the hair shafts (trichoschisis). Trichoschisis is characterized by a sharp transverse fracture of the hair shaft." ; dc:date "2022-09-04T19:03:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Hair from individuals with trichothiodistrophy (TTD) exhibits an alternating light and dark (so-called tiger tail) banding pattern with trichoschisis. See figure 2 of PMID:23180925." ; rdfs:label "Trichoschisis" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0034355 obo:IAO_0000115 "On computed tomography of the brain,the white (or dense) cerebellum sign is seen when the cerebellum appears dense with respect to the cerebral parenchyma. The increase in attenuation of cerebellum is in fact a relative hyperdensity caused by decreased attenutation of the brain. It represents anoxic-ischemic cerebral injury, and has a very poor prognosis." ; dc:date "2022-09-04T19:22:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See figure 30 in PMID:29089832." ; rdfs:label "White cerebellum sign" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0034356 obo:IAO_0000115 "Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption." ; dc:date "2022-09-04T19:41:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased low molecular weight protein excretion" ; a owl:Class ; rdfs:comment "Urinary proteins are reabsorbed by the renal tubule cells, and increased low molecular weight protein fractional excretion can be a sign of tubular proteinuria." ; rdfs:label "Impaired renal tubular reabsorption of low molecular weight protein" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0034357 obo:IAO_0000115 "Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption." ; dc:date "2022-09-04T19:42:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired renal tubular reabsorption of glucose" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0034358 obo:IAO_0000115 "Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption." ; dc:date "2022-09-04T19:45:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired renal tubular reabsorption of sodium" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0034359 obo:IAO_0000115 "Increased fractional excretion (FE) of glucose in the phosphate. The FE of glucose is the percentage of the phosphate filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine phosphate, rather than by the interpretation of urinary phosphate concentration alone, as urinary glucose concentrations can vary with water reabsorption." ; dc:date "2022-09-04T19:48:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired renal tubular reabsorption of phosphate" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_0034360 obo:IAO_0000115 "A type of myoclonus (arrhythmic muscular jerking) that is induced by voluntary movement. It is made worse by attempts at precise or coordinated movement (intention myoclonus) and may also be provoked by certain sensory stimuli." ; dc:date "2022-09-04T19:51:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Action myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0034361 obo:IAO_0000115 "Greater than normal amount of skin surrounding the umbilicus (belly button) with protrusion of the umbilicus above the plane of the abdomen." ; dc:date "2022-09-04T21:36:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 4c of PMID:8944018." ; rdfs:label "Redundant umbilical skin" ; rdfs:subClassOf obo:HP_0004298 . obo:HP_0034362 obo:IAO_0000115 "Reduced brigthness of the foveal reflex, which normally is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope." ; dc:date "2022-09-04T21:42:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased foveal light reflex", "Muted foveal light reflex", "Poor foveal light reflex" ; a owl:Class ; rdfs:comment "A dull foveal reflex is an unusual reflex of the foveal region on fundoscopy that may indicate hypoplasia of the fovea." ; rdfs:label "Dull foveal reflex" ; rdfs:subClassOf obo:HP_0000493 . obo:HP_0034363 obo:IAO_0000115 "Corneal pterygium is an ocular surface disease characterized mainly by a wing-shaped growth of limbal and conjunctival tissue over the adjacent cornea." ; dc:date "2022-09-04T21:55:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Surfer's eye", "Wing-shaped conjunctiva" ; a owl:Class ; rdfs:comment "In ophthalmological contexts, the word 'pterygium' is frequently used without further qualifiers to denote corneal pterygium." ; rdfs:label "Corneal pterygium" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0034364 obo:IAO_0000115 "Replacement of the myocardium of the right ventricular free wall by fat and fibrous tissue." ; dc:date "2022-09-04T22:33:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fibrofatty replacement of right ventricular myocardium" ; rdfs:subClassOf obo:HP_0001707 . obo:HP_0034365 obo:IAO_0000115 "Increased concentration of alpha-aminoadipic semialdehyde in the blood circulation." ; dc:date "2022-09-04T22:44:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating piperideine-6-carboxylic acid concentration" ; a owl:Class ; rdfs:label "Elevated circulating alpha-aminoadipic semialdehyde concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0034366 obo:IAO_0000115 "Fracture blister is a type of blister that forms following acute bone fractures, typically near the ankle, wrist elbow or foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn." ; dc:date "2022-09-05T00:14:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fracture blister" ; rdfs:subClassOf obo:HP_0033800 . obo:HP_0034367 obo:IAO_0000115 "Activity of the enzyme beta-mannosidase below the lower limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides." ; dc:date "2022-09-05T00:50:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased beta-mannosidase activity" ; rdfs:subClassOf obo:HP_0034725 . obo:HP_0034368 obo:IAO_0000115 "Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra." ; dc:date "2022-09-05T01:02:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Urolithiasis" ; rdfs:subClassOf obo:HP_0025633 . obo:HP_0034369 obo:IAO_0000115 "Reduced amount of coenzyme Q10,a naturally occurring quinone, in skeletal muscle tissue." ; dc:date "2022-09-05T10:57:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased level of coenzyme Q10 in skeletal muscle" ; rdfs:subClassOf obo:HP_0034370 . obo:HP_0034370 dc:date "2022-09-05T10:59:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal muscle tissue metabolite concentration" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0032243 . obo:HP_0034371 obo:IAO_0000115 "Reduced concentration of prekallikrein (PK; also known as Fletcher factor) in the blood circulation. PK is the precursor of plasma kallikrein, a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII." ; dc:date "2022-09-05T11:22:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Most cases of prekallikrein deficiency are asymptomatic." ; rdfs:label "Reduced circulating prekallikrein concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034372 dc:date "2022-09-05T11:27:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Internal tibial rotation" ; a owl:Class ; rdfs:comment "Internal twisting of the tibia resulting in the toes of each foot pointing inward (intoeing) ." ; rdfs:label "Internal tibial torsion" ; rdfs:subClassOf obo:HP_0100694 . obo:HP_0034373 obo:IAO_0000115 "External twisting of the tibia resulting in the toes of each foot pointing outward (outtoeing) ." ; dc:date "2022-09-05T11:27:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "External tibial rotation" ; a owl:Class ; rdfs:label "External tibial torsion" ; rdfs:subClassOf obo:HP_0100694 . obo:HP_0034374 obo:IAO_0000115 "Abnormal appearance of the acetabulum characterized by spurs at the medial and lateral acetabular margin and in the center of the acetabulum, giving rise to shape resembling a three-pronged spear sadi to resemble a trident." ; dc:date "2022-09-05T11:35:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trident acetabula" ; a owl:Class ; rdfs:comment "See figure 2 of PMID:28744080." ; rdfs:label "Trident acetabulum" ; rdfs:subClassOf obo:HP_0010454 . obo:HP_0034375 obo:IAO_0000115 "Spherophakia is a rare congenital condition that presents with weak zonules around a smaller and more spherical crystalline lens with an increased anteroposterior thickness of the lens, and highly myopic eye. The lens zonules are developmentally hypoplastic and abnormally weak and due to non-attachment of the posterior zonules to the equatorial zone of the lens, the lens changes its normal shape to spherical." ; dc:date "2022-09-05T11:42:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spherophakia" ; rdfs:subClassOf obo:HP_0011526 . obo:HP_0034376 obo:IAO_0000115 "Regurgitation of a heart valve that controls blood flow from a an atrium to a ventricle, including mitral, tricuspid, or, rarely, single atrioventicular valve." ; dc:date "2022-09-05T11:50:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atrioventricular valve regurgitation" ; rdfs:subClassOf obo:HP_0031650 . obo:HP_0034377 obo:IAO_0000115 "Regurgitation of the single atrioventricular valve regurgitation (AVVR) in the context of a congenital heart defect with a single ventricle. Roughly three quarters of patients following Fontan procedure display AVVR." ; dc:date "2022-09-05T11:55:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Single atrioventricular valve regurgitation" ; rdfs:subClassOf obo:HP_0034376 . obo:HP_0034378 obo:IAO_0000115 "Blockage of the flow of urine from the bladder into the urethra." ; dc:date "2022-09-05T13:18:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Urethrovesical occlusion" ; rdfs:subClassOf obo:HP_0000796 . obo:HP_0034379 obo:IAO_0000115 "Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide." ; obo:IAO_0100001 "HP:0003657" ; dc:date "2022-09-05T13:46:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Vascular granular osmiophilic material deposition" ; owl:deprecated true . obo:HP_0034380 obo:IAO_0000115 "Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia." ; dc:date "2022-09-05T13:51:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Juvenile type testicular granulosa cell tumor" ; rdfs:subClassOf obo:HP_0010788 . obo:HP_0034381 obo:IAO_0000115 "Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements." ; dc:date "2022-09-05T13:54:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CNS axonal spheroid" ; a owl:Class ; rdfs:label "Central nervous system axonal spheroid" ; rdfs:subClassOf obo:HP_0002011 . obo:HP_0034382 obo:IAO_0000115 "A decrease in or disappearance of signs and symptoms typically associated with a disease course." ; dc:date "2022-09-05T14:19:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Disease remission" ; rdfs:subClassOf obo:HP_0031797 . obo:HP_0034383 obo:IAO_0000115 "Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation." ; dc:date "2022-09-07T13:06:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating biliverdin concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0034384 obo:IAO_0000115 "Increased ratio of insulin to C-peptide in the blood circulation." ; dc:date "2022-09-07T13:34:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Insulin and C-peptide are secreted into portal vein in equimolar amounts, but the serum ratio is normally from 1:5 to 1:15 due to removal of approximately 50% of insulin from blood during initial passage through the liver." ; rdfs:label "Elevated circulating insulin:C-peptide ratio" ; rdfs:subClassOf obo:HP_0040214 . obo:HP_0034385 obo:IAO_0000115 "A deviation from the normal range of the left ventricular endsystolic diameter." ; dc:date "2022-09-07T13:37:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The measurement of the left ventricular endsystolic diameter is performed in the parasternal long-axis view, perpendicular to the long axis of the left ventricle at the tips of the mitral valve leaflets. It refers to the transverse (left-to-right) internal (luminal) distance, excluding thickness of walls. The normal range can be taken as 20-40 mm (total 2SD range 17.6-52.3 according to PMID:24451180)." ; rdfs:label "Abnormal left ventricular endsystolic diameter" ; rdfs:subClassOf obo:HP_0025169 . obo:HP_0034386 obo:IAO_0000115 "A lower than normal left ventricular endsystolic diameter." ; dc:date "2022-09-07T13:39:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced left ventricular endsystolic diameter" ; rdfs:subClassOf obo:HP_0034385 . obo:HP_0034387 obo:IAO_0000115 "Encephalitis caused by bacterial infection." ; dc:date "2022-09-07T13:43:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bacterial encephalitis" ; rdfs:subClassOf obo:HP_0002383 . obo:HP_0034388 obo:IAO_0000115 "Hilar lymphadenopathy is swelling or enlargement of lymph nodes localised in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral)." ; dc:date "2022-09-26T18:39:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hilar adenopathy", "Hilar lymphadenopathy" ; a owl:Class ; rdfs:label "Hilar lymph node enlargement" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0034389 obo:IAO_0000115 "Pulmonary vein varix (PVV), refers to a localised dilatation of a pulmonary vein. PVV is a rare condition and can be congenital or acquired. PVV typically occur at the confluence of the veins adjacent to the left atrium. PVVs are sometimes classified into three morphological types: saccular, tortuous and confluent." ; dc:date "2022-09-26T18:41:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pulmonary vein dilatation" ; a owl:Class ; rdfs:label "Pulmonary vein varix" ; rdfs:subClassOf obo:HP_0030968 . obo:HP_0034390 obo:IAO_0000115 "Abnormally decreased levels of glycine in cerebrospinal fluid." ; dc:date "2022-09-30T12:23:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glycine low in CSF" ; a owl:Class ; rdfs:label "Decreased CSF glycine concentration" ; rdfs:subClassOf obo:HP_0500229 . obo:HP_0034391 obo:IAO_0000115 "A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin." ; dc:date "2022-09-30T12:50:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elbow contracture" ; rdfs:subClassOf obo:HP_0100360 . obo:HP_0034392 obo:IAO_0000115 "A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part." ; dc:date "2022-09-30T12:53:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Contracture" ; a owl:Class ; rdfs:comment "To assess a joint contracture, the passive or active range of motion (ROM) of a joint with a contracture is assessed by moving the joint through its natural range with no active effort from the individual. The angular distance of the joint motion and the loss of ROM in a contracture is recorded through comparison with the contralateral joint or normative values. Conventionally, a joint contracture is named according to the joint involved and the direction opposite the lack of range. For example, inability to fully extend the knee is referred to as a knee flexion contracture, compared to inability to bend (flex) the knee, which is referred to as a knee extension contracture. Contractures in neuromuscular diseases develop due to intrinsic myotendinous structural changes and extrinsic factors. Known contributing extrinsic factors include decreased ability to actively move a limb through its full range of motion, immobility or static positioning for prolonged periods of time, and agonist antagonist muscle imbalance. Intrinsic muscle tissue alterations in dystrophic myopathies contribute to contracture formation. The most significant histologic changes are those of muscle fiber loss, abnormal residual dystrophic muscle fibers, segmental necrosis of muscle fibers, and increased amounts of adipose tissue, connective tissue, and fibrosis." ; rdfs:label "Joint contracture" ; rdfs:subClassOf obo:HP_0003549, obo:HP_0011729, obo:HP_0011805, obo:HP_0100261 . obo:HP_0034393 obo:IAO_0000115 "An elbow contracture that limits the ability of the elbow joint to flex (flexion of the the elbow joint refers to bending the elbow joint to bring the hand closer to the shoulder), meaning that the elbow is fixed in an extended (straight) position." ; dc:date "2022-09-30T12:57:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elbow extension contracture" ; rdfs:subClassOf obo:HP_0034391 . obo:HP_0034394 obo:IAO_0000115 "A contracture that limits the ability of the forearm to stabilize the hand in pronation (pronation refers to a rotation of the forearm that causes the palm and forearm to face downwards), meaning that the palm is fixed in a upward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between." ; dc:date "2022-09-30T13:01:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Supination contracture of the forearm" ; a owl:Class ; rdfs:label "Forearm supination contracture" ; rdfs:subClassOf obo:HP_0100360 . obo:HP_0034395 obo:IAO_0000115 "A contracture that limits the ability of the forearm to stabilize the hand in supiation (supination refers to a rotation of the forearm that causes the palm and forearm to face upwards), meaning that the palm is fixed in a downward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between." ; dc:date "2022-09-30T13:04:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pronation contracture of the forearm" ; a owl:Class ; rdfs:label "Forearm pronation contracture" ; rdfs:subClassOf obo:HP_0100360 . obo:HP_0034396 obo:IAO_0000115 "Hippocampal malrotation, also termed incomplete inversion of the hippocampus or hippocampal malformation, is an increasingly recognized neuroimaging finding of undetermined clinical significance. It is characterized by features including (i) Round or pyramidal shape instead of ovoid shape; (ii) Medial position of the hippocampus on the hippocampal sulcus; (iii) The collateral sulcus is excessively deep or verticalized; (iv) Fimbria located medial to the hippocampus; (v) Small or displaced fornix; (vi) Enlarged temporal horn and empty choroid fissure; (vii) Thickened subiculum; (viii) Reduced upper horizontal portion of the parahippocampal gyrus." ; dc:date "2022-11-05T13:15:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hippocampal malrotation" ; rdfs:subClassOf obo:HP_0025100 . obo:HP_0034397 obo:IAO_0000115 "Claw toes are characterized by hyperextension at the metatarsal-phalangeal joints and flexion of the interphalangeal joints." ; dc:date "2022-11-05T13:23:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Claw teo deformity is commonly seen in neuromuscular disorders." ; rdfs:label "Claw toe deformity" ; rdfs:subClassOf obo:HP_0034398 . obo:HP_0034398 obo:IAO_0000115 "Abnormal positioning of toe phalanges. Deformities of the lesser toes often occur gradually, though they can be brought on by trauma. The main adult sagittal plane deformities consist of claw toes, hammer toes and mallet toes. Axial plane deformities include crossover toes." ; dc:date "2022-11-05T13:26:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Toe deformity" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0034399 obo:IAO_0000115 "Increased duration of the central motor conduction time (CMCT). The CMCT estimates the conduction time of corticospinal fibers between motor cortex and spinal (or bulbar) motoneurons. It includes the times for excitation of cortical cells, conduction via the corticobulbar-corticospinal tract and excitation of the motoneuron sufficient to reach its firing threshold. CMCT is calculated by subtracting the peripheral conduction time from the MEP latency recorded after cortical stimulation." ; dc:date "2022-11-05T13:36:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The determination of central motor conduction time is a sensitive method to detect myelopathies, and abnormalities may be observed in the absence of radiological changes." ; rdfs:label "Prolonged central motor conduction time" ; rdfs:subClassOf obo:HP_0012079 . obo:HP_0034400 obo:IAO_0000115 "Ringed creases of the skin of the extremities related to folding of excess skin." ; dc:date "2022-11-05T13:58:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Circumferential skin creases on extremities" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0034401 obo:IAO_0000115 "An aggressive malignant embryonal neoplasm arising from the central nervous system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. Mutations of the SMARCB1 gene or very rarely SMARCA4 (BRG1) gene are present. The vast majority of cases occur in childhood. Symptoms include lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia." ; dc:date "2022-11-05T14:03:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atypical teratoid/rhabdoid tumor" ; rdfs:subClassOf obo:HP_0002898 . obo:HP_0034402 obo:IAO_0000115 "A highly aggressive, extremely rare neoplasm of the kidney that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers, and pathologic diagnosis requires familiarity with these microscopic features plus awareness that adult onset is possible. It can be associated with abnormalities of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm." ; dc:date "2022-11-05T14:04:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Malignant rhabdoid tumor of the kidney", "Malignant rhabdoid tumour of the kidney" ; a owl:Class ; rdfs:label "Rhabdoid tumor of the kidney" ; rdfs:subClassOf obo:HP_0009726, obo:HP_0034557 . obo:HP_0034403 obo:IAO_0000115 "A form of T-cell non-Hodgkin lymphoma in which cytotoxic CD8+ T cells infiltrate adipose tissue forming subcutaneous nodules." ; dc:date "2022-11-05T14:05:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Subcutaneous panniculitis-like T-cell lymphoma" ; rdfs:subClassOf obo:HP_0012190 . obo:HP_0034404 obo:IAO_0000115 "Presence of hyphae (long, branching, filamentous structures produced by fungi) in sputum." ; dc:date "2022-11-06T22:10:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fungal hyphae in sputum" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0034405 obo:IAO_0000115 "Increasaed size of the tectum, which is the region of the midbrain posterior to the cerebral aqueduct of Sylvius. The midbrain is the most superior portion of the brainstem." ; dc:date "2022-11-10T12:11:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thick tectum" ; a owl:Class ; rdfs:label "Enlarged tectum" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0034406 dc:date "2022-11-10T12:14:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Angiotensin-converting enzyme (ACE) high in CSF", "Angiotensin-converting enzyme high in CSF" ; a owl:Class ; rdfs:label "Elevated CSF angiotensin-converting enzyme concentration" ; rdfs:subClassOf obo:HP_0025456 . obo:HP_0034407 obo:IAO_0000115 "Decreased concentration of 3-ketoacyl-CoA thiolase in th blood circulation." ; dc:date "2022-11-10T12:26:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "3-ketoacyl-CoA thiolase (THIO) deficiency" ; a owl:Class ; rdfs:label "Reduced circulating 3-ketoacyl-CoA thiolase concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034408 obo:IAO_0000115 "A dark, keratotic papule about 2-10 mm in diameter, usually occuring on the lower extremeities. Usually the lesions begin as bright, soft, and nonkeratotic paules which grow larger and change to a firm, blue to black and keratotic stage." ; dc:date "2022-11-10T12:37:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Solitary angiokeratomas most commonly occur in the third or fourth decade of life but may occur in children." ; rdfs:label "Solitary angiokeratoma" ; rdfs:subClassOf obo:HP_0001014 . obo:HP_0034409 obo:IAO_0000115 "A type of angiokeratoma that most commonly occurs on the scrotum of patients who are 40 years old or older. The typical single lesion is a dark red to blue dome-shaped papule 2-4 mm in diameter with a very discrete keratotic surface. Typically, they are multiple and arranged in a line parallel to the raphe mediana of the scrotum. They also occur on the vulva and less commnly on the penis." ; dc:date "2022-11-10T12:41:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fordyce angiokeratoma" ; rdfs:subClassOf obo:HP_0001014 . obo:HP_0034410 obo:IAO_0000115 "A type of angiokeratoma that typically presents in childhood as a large, mostly linear and unilateral hyperkeratotic plaque which is composed of confluent keratotic papules. The size ranges from a few centimeters up to a major part of the body surface. Initially the lesions present asa multile reddish macules, clinically similar to a nevus flammeus. Within several years they develop into acanthokeratotic papules that agrregate into plaques which may have a hyperkeratotic surface." ; dc:date "2022-11-10T12:51:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Angiokeratoma circumscriptum naeviforme" ; rdfs:subClassOf obo:HP_0001014 . obo:HP_0034411 obo:IAO_0000115 "A type of angiokeratoma that typically presents in women on the dorsa of fingers and toes and multiple dark red papules with a slightly verrucous surface, each measuring about 3-5 mm in diameter." ; dc:date "2022-11-10T12:54:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Angiokeratoma of Mibelli" ; rdfs:subClassOf obo:HP_0001014 . obo:HP_0034412 obo:IAO_0000115 "A lump in the region of the larynx. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup. Laryngeal masses can be visualized by multiple methods include computed tomography." ; dc:date "2022-11-10T13:08:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Laryngeal mass" ; rdfs:subClassOf obo:HP_0025423 . obo:HP_0034413 obo:IAO_0000115 "A lump in the region of the palate. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup." ; dc:date "2022-11-10T13:18:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palate mass" ; rdfs:subClassOf obo:HP_0000174 . obo:HP_0034414 obo:IAO_0000115 "Increased thickness of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip." ; dc:date "2022-11-10T13:20:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "oral frenulum, thick" ; a owl:Class ; rdfs:label "Thick oral frenulum" ; rdfs:subClassOf obo:HP_0000190 . obo:HP_0034415 obo:IAO_0000115 "A type of dental trauma characterized by total dislocation of the tooth from its socket." ; dc:date "2022-11-10T13:22:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Avulsed tooth", "Teeth: avulsion" ; a owl:Class ; rdfs:label "Tooth avulsion" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0034416 obo:IAO_0000115 "Laceration or tear of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip." ; dc:date "2022-11-10T13:24:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Laceration of oral frenulum", "Oral frenulum, torn" ; a owl:Class ; rdfs:label "Torn oral frenulum" ; rdfs:subClassOf obo:HP_0000190 . obo:HP_0034417 obo:IAO_0000115 "A wound of the mucosa within the oral cavity covering lips, tongue, palate, gingiva, pharynx, or retropharynx." ; dc:date "2022-11-10T13:26:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intraoral lacerations" ; a owl:Class ; rdfs:label "Intraoral laceration" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0034418 obo:IAO_0000115 "An erythematous lesion of the oral mucosa may result from a variety of tissue alterations, including inflammation, erythrocyte extravasation, and atrophy or reduced keratinization of the surface epithelium." ; dc:date "2022-11-10T13:27:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Oral mucosa erythema" ; a owl:Class ; rdfs:label "Erythematous oral mucosa" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0034419 obo:IAO_0000115 "Breakage of the chordae tendinae of the mitral valve. This can lead to loss of tension of one of the mitral valve leaflets and mitral regurgitation." ; dc:date "2022-11-12T11:59:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The chordae provide the critical function of anchoring the mitral leaflets during systole, allowing for symmetric coaptation and preventing prolapse of the leaflets into the left atrium. The chordae are attached to the left ventricle via the papillary muscles." ; rdfs:label "Mitral chordae tendinae rupture" ; rdfs:subClassOf obo:HP_0025523 . obo:HP_0034420 obo:IAO_0000115 "Indicates that a cardiovascular procedure such as stenting, bypass, catherization was performed on a patient." ; dc:date "2022-11-12T12:05:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:0189573" ; a owl:Class ; rdfs:label "History of cardiovascular procedure" ; rdfs:subClassOf obo:HP_0032443 . obo:HP_0034421 obo:IAO_0000115 "A high-pitched sound that occurs at the moment of maximal opening of the aortic or pulmonary valves. They are heard just after the first heart sound. The sounds occur in the presence of a dilated aorta or pulmonary artery or in the presence of a bicuspid or flexible stenotic aortic or pulmonary valve. Ejection clicks may also be called ejection sounds." ; dc:date "2022-11-12T12:09:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "PMID:21250045" ; oboInOwl:hasExactSynonym "Cardiac click sound on auscultation" ; a owl:Class ; rdfs:label "Ejection click" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0034422 obo:IAO_0000115 "Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. consisting of fibrinogen, fibronectin, alpha1-antitrypsin and alpha2-macroglobulin." ; dc:date "2022-11-12T12:21:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cryofibrinogenemia (CF) can be detected in both healthy persons and patients with different disorders, including autoimmune diseases, cancer, infections, etc. Cryofibrinogen should be distinguished from cryoglobulin since, unlike the latter, it precipitates only in plasma and not in serum." ; rdfs:label "Cryofibrinogenemia" ; rdfs:subClassOf obo:HP_0011898 . obo:HP_0034423 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to allergens." ; dc:date "2022-11-12T12:27:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "triggered by allergens" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0034424 obo:IAO_0000115 "A type of tinnitus that presents as clicks, resembling the noise made by the snapping together of 2 fingers." ; dc:date "2022-11-12T12:34:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Clicking tinnitus may be caused by conditions including palatal myoclonus, which is characterised by a rhythmic contraction of the palatal muscles including the levator veli palatini and the tensor palatini muscles." ; rdfs:label "Clicking tinnitus" ; rdfs:subClassOf obo:HP_0000360 . obo:HP_0034425 obo:IAO_0000115 "Abnormally low amount of sulfur in hair." ; dc:date "2022-11-12T12:52:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hair sulfur content reduced", "Hair sulphur content reduced" ; a owl:Class ; rdfs:comment "Normal hair keratin is high in sulfur content." ; rdfs:label "Reduced hair sulfur content" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0034426 obo:IAO_0000115 "Secretion of colored sweat." ; dc:date "2022-11-23T23:13:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "While chromhidrosis is a clinical diagnosis, further studies may be needed to ascertain the type and cause of chromhidrosis if not apparent from the history and physical examination. A Wood's lamp will fluoresce green, blue, and yellow apocrine gland secretions yellow, while black and dark brown secretions usually do not fluoresce." ; rdfs:label "Chromhidrosis" ; rdfs:subClassOf obo:HP_0000971 . obo:HP_0034427 obo:IAO_0000115 "Secretion of pus-like (purulent) material from the eye, which may caused the eyelids to be matted together." ; dc:date "2022-11-23T23:18:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mucopurulent discharge from the eye" ; a owl:Class ; rdfs:label "Purulent eye discharge" ; rdfs:subClassOf obo:HP_0100533 . obo:HP_0034428 obo:IAO_0000115 "Disproportionately large eyelids" ; dc:date "2022-11-23T23:23:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Megaloblepharon" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0034429 obo:IAO_0000115 "Presence of bacteria in the cerebrospinal fluid, as manifested by visual inspection or bacterial culture results." ; dc:date "2022-11-24T00:12:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bacteria in CSF" ; a owl:Class ; rdfs:label "Bacteria in cerebrospinal fluid" ; rdfs:subClassOf obo:HP_0034747 . obo:HP_0034430 dc:date "2022-11-24T00:18:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal joint physiology" ; rdfs:subClassOf obo:HP_0011843 . obo:HP_0034431 obo:IAO_0000115 "A popping, clicking or crackling sound that accompaniees movement of a joint." ; dc:date "2022-11-24T00:18:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Joint crepitus" ; rdfs:subClassOf obo:HP_0034430 . obo:HP_0034432 obo:IAO_0000115 "Applies to the localization of a skin lesion involving any area of the body where two opposing skin surfaces can touch and rub or chaff." ; dc:date "2022-11-26T13:08:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Intertriginous distribution of skin lesions" ; a owl:Class ; rdfs:comment "The word intertrigo comes from the Latin inter (between) and terere (to rub) and reflects the rubbing together of skin against skin to create maceration and irritation, hence, friction dermatitis or chaffing." ; rdfs:label "Intertriginous distribution" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0034433 obo:IAO_0000115 "Applies to the localization of a skin lesion that correspond to skin tension lines, which are linear clefts in the skin that indicate the direction of orientation of the underlying collagen fibers. Skin tension lines are also known as Langer's lines or lines of cleavage." ; dc:date "2022-11-26T13:11:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Distributed along Langer's lines", "Lesions follow lines of cleavage" ; a owl:Class ; rdfs:label "Distributed along skin tension lines" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0034434 obo:IAO_0000115 "Presence of any form of communication (e.g., verbal or non-verbal) that does not align with cultural expectations or developmental level." ; dc:date "2022-11-26T13:19:28Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal communication" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0034435 obo:IAO_0000115 "Any abnormality of eye contact behavior. We define eye contact as a form of nonverbal communication between two individuals who are facing each other in which an individual directs the eyes towards the eyes or face of the other individual. Eye contact occurs frequently and voluntarily during face-to-face verbal communication. The duration and frequency of eye contact that is interpreted to be appropriate may follow social and situational norms." ; dc:date "2022-11-26T13:20:57Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal eye contact" ; rdfs:subClassOf obo:HP_0000758 . obo:HP_0034436 obo:IAO_0000115 "A deliberate avoidance of eye contact." ; dc:date "2022-11-26T13:30:07Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Gaze aversion" ; a owl:Class ; rdfs:label "Gaze avoidance" ; rdfs:subClassOf obo:HP_0034435 . obo:HP_0034437 obo:IAO_0000115 "Tendency to maintain sustained eye contact for an inappropriately long period of time." ; dc:date "2022-11-26T13:34:40Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Excessive eye contact" ; rdfs:subClassOf obo:HP_0034435 . obo:HP_0034438 obo:IAO_0000115 "Inflammation of glans penis" ; dc:date "2022-11-26T13:37:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Balanitis" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001299 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034439 obo:IAO_0000115 "Applies to an abnormality that is situated in the arched middle portion of the foot in front of the ankle joint (i.e., instep)." ; dc:date "2022-11-26T13:40:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Instep localization to skin abnormality" ; a owl:Class ; rdfs:label "Instep location" ; rdfs:subClassOf obo:HP_0012838 . obo:HP_0034440 obo:IAO_0000115 "Applies to a skin lesion that is improved or made more bearable by exposure to ultraviolet light (sunshine or phototherapy)." ; dc:date "2022-11-26T13:42:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ultraviolet exposure improves condition" ; a owl:Class ; rdfs:label "Ameliorated by ultraviolet light exposure" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034441 obo:IAO_0000115 "An reduced concentration of aspartic acid in the blood circulation." ; dc:date "2022-11-26T13:49:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aspartic acid low in blood" ; a owl:Class ; rdfs:label "Decreased circulating aspartic acid concentration" ; rdfs:subClassOf obo:HP_0500158 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17053 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034442 obo:IAO_0000115 "Any deviation from the normal concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production." ; dc:date "2022-11-26T14:00:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating erythropoietin concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034443 obo:IAO_0000115 "Decreased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production." ; dc:date "2022-11-26T14:01:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Erythropoietin low in blood" ; a owl:Class ; rdfs:label "Reduced circulating erythropoietin concentration" ; rdfs:subClassOf obo:HP_0034442 . obo:HP_0034444 obo:IAO_0000115 "Any deviation from the normal level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues." ; dc:date "2022-11-26T14:05:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "A common reference range for children an adults is between 0 and 30 international units per liter (IU/L)." ; rdfs:label "Abnormal gamma-glutamyltransferase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034445 obo:IAO_0000115 "Decreased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues." ; dc:date "2022-11-26T14:07:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gamma-glutamyl transferase low in blood" ; a owl:Class ; rdfs:label "Reduced gamma-glutamyltransferase level" ; rdfs:subClassOf obo:HP_0034444 . obo:HP_0034446 obo:IAO_0000115 "Increased concentration of histamine in the blood circulation." ; dc:date "2022-11-26T14:10:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Histamine high in blood" ; a owl:Class ; rdfs:comment "The blood histamine concentration is normally very low but may be increased if released from activated mast cells, for example in an allergic response." ; rdfs:label "Elevated circulating histamine concentration" ; rdfs:subClassOf obo:HP_0033405 . obo:HP_0034447 obo:IAO_0000115 "An increased concentration of interleukin-18 in the blood circulation." ; dc:date "2022-11-26T14:13:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-18 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 18 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034448 obo:IAO_0000115 "Any deviation from the normal ratio of blood phytanic acid concentration to pristanic acid concentration." ; dc:date "2022-11-26T14:18:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal phytanic acid to pristanic acid ratio", "Abnormal phytanic acid/pristanic acid ratio" ; a owl:Class ; rdfs:comment "The pristanic acid/phytanic acid ratio is of value for the differential diagnosis of Refsum disease, rhizomelic chondrodysplasia punctata, peroxisome deficiency disorders and isolated peroxisomal beta-oxidation defects." ; rdfs:label "Abnormal phytanic acid:pristanic acid ratio" ; rdfs:subClassOf obo:HP_0010964 . obo:HP_0034449 obo:IAO_0000115 "An elevation above the normal ratio of blood phytanic acid concentration to pristanic acid concentration." ; dc:date "2022-11-26T14:26:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phytanic acid to pristanic acid ratio high" ; a owl:Class ; rdfs:comment "This feature may be observed in diseases such as Alpha-methylacyl-CoA racemase deficiency." ; rdfs:label "Increased phytanic acid:pristanic acid ratio" ; rdfs:subClassOf obo:HP_0034448 . obo:HP_0034450 obo:IAO_0000115 "A reduction below the normal ratio of blood phytanic acid concentration to pristanic acid concentration." ; dc:date "2022-11-26T14:30:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phytanic acid to pristanic acid ratio low" ; a owl:Class ; rdfs:label "Decreased phytanic acid:pristanic acid ratio" ; rdfs:subClassOf obo:HP_0034448 . obo:HP_0034451 obo:IAO_0000115 "An aberrant, pathological communication between the rectum and the bladder." ; dc:date "2022-11-26T14:46:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vesicorectal fistula" ; a owl:Class ; rdfs:label "Rectovesical fistula" ; rdfs:subClassOf obo:HP_0004321, obo:HP_0100590 . obo:HP_0034452 obo:IAO_0000115 "An abnormal connection (fistula) between the rectum and the ureter." ; dc:date "2022-11-26T14:49:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rectoureteral fistula" ; rdfs:subClassOf obo:HP_0100590 . obo:HP_0034453 obo:IAO_0000115 "Underdevelopment of the umbilicus." ; dc:date "2022-11-26T14:50:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Umbilicus hypoplastic" ; a owl:Class ; rdfs:label "Hypoplastic umbilicus" ; rdfs:subClassOf obo:HP_0001551 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034454 obo:IAO_0000115 "Arachnoid granulations (AGs) are tufts of arachnoid membrane invaginated into the dural sinuses through which cerebrospinal fluid (CSF) enters the venous system. The lesions are primarily located in the parasagittal region along the superior sagittal sinus, which is occasionally seen at the transverse sinus. Normally dural venous sinus AGs typically range from 2 to 8 mm in size, but may grow enough to expand the dural sinuses, and even the inner table, diploic space and outer table of the skull." ; dc:date "2022-12-03T22:24:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Arachnoid granulation" ; rdfs:subClassOf obo:HP_0100700 . obo:HP_0034455 obo:IAO_0000115 "Increased concentration of taurine in the cerebrospinal fluid (CSF)." ; dc:date "2022-12-03T22:26:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Taurine high in CSF" ; a owl:Class ; rdfs:label "Increased CSF taurine concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034456 obo:IAO_0000115 "An abnormally increased level of glutathione in the blood circulation." ; dc:date "2022-12-03T22:30:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glutathione high in blood" ; a owl:Class ; rdfs:label "Elevated circulating glutathione concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034457 obo:IAO_0000115 "The concentration of hawkinsin in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2022-12-03T22:34:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hawkinsin high in urine" ; a owl:Class ; rdfs:comment "Hawkinsin is a cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group." ; rdfs:label "Hawkinsinuria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034458 obo:IAO_0000115 "An abnormally increased amount of phenylpyruvic acid in the urine." ; dc:date "2022-12-04T14:26:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phenylpyruvic acid high in urine" ; a owl:Class ; rdfs:label "Elevated urinary phenylpyruvic acid level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034459 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by lumbar puncture." ; dc:date "2022-12-03T23:21:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lumbar puncture relieves symptoms" ; a owl:Class ; rdfs:label "Ameliorated by lumbar puncture" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034460 obo:IAO_0000115 "An increased level of uracil in the cerebrospinal fluid." ; dc:date "2022-12-03T23:24:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased CSF uracil concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17568 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034461 obo:IAO_0000115 "An abnormally increased amount of kynurenine in the urine." ; dc:date "2022-12-04T14:30:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Kynurenine high in urine" ; a owl:Class ; rdfs:label "Elevated urine kynurenine level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034462 obo:IAO_0000115 "An abnormally increased concentration of L-alloisoleucine in the cerebrospinal fluid (CSF)." ; dc:date "2022-12-04T14:35:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "L-alloisoleucine high in CSF" ; a owl:Class ; rdfs:label "Increased CSF L-alloisoleucine concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034463 obo:IAO_0000115 "An increased concentration of hydroxylysine in the blood circulation. Hydroxylysine arises from a post-translational hydroxy modification of lysine and is unique to collagen and proteins containing collagen-like sequences. Elevated concentrations of hydroxylysine may indicate increased bone turnover." ; dc:date "2022-12-04T14:40:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hydroxylysine present in blood" ; a owl:Class ; rdfs:label "Hydroxylysinemia" ; rdfs:subClassOf obo:HP_0010908 . obo:HP_0034464 obo:IAO_0000115 "An increased amount of L-homocitrulline in the urine. L-homocitrulline is an L-lysine derivative that is L-lysine having a carbamoyl group at the N(6)-position. It is found in individuals with urea cycle disorders." ; dc:date "2022-12-04T14:49:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Homocitrulline present in urine" ; a owl:Class ; rdfs:label "Homocitrullinuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0034465 obo:IAO_0000115 "An increase in the level of 2-hydroxyadipic acid in the urine." ; dc:date "2022-12-04T14:57:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2-hydroxyadipic acid high in urine" ; a owl:Class ; rdfs:label "2-hydroxyadipic aciduria" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034466 obo:IAO_0000115 "An increased amount of homoarginine in the urine. Homoarginine is a nonproteinogenic alpha amino acid." ; dc:date "2022-12-04T14:59:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Homoarginine high in urine" ; a owl:Class ; rdfs:label "Homoargininuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0034467 obo:IAO_0000115 "An increased concentration of cysteine in the urine." ; dc:date "2022-12-04T15:05:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary cysteine level" ; rdfs:subClassOf obo:HP_0033095 . obo:HP_0034468 obo:IAO_0000115 "Gastric xanthomas (also known as xanthelasmas) are are plaque-like red lesions defined by the presence of histiocytic containing lipids." ; dc:date "2022-12-04T15:14:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gastric xanthomas", "Gastric xanthomata" ; a owl:Class ; rdfs:comment "Gastrix xanthoma is usually an incidental endoscopic finding of unclear clinical significance." ; rdfs:label "Gastric xanthoma" ; rdfs:subClassOf obo:HP_0002577 . obo:HP_0034469 obo:IAO_0000115 "Reduced amount of pancreatic elastase in the stool. This feature may be observed with pancreatic insufficiency." ; dc:date "2022-12-04T15:30:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elastase low in stool" ; a owl:Class ; rdfs:label "Decreased stool elastase level" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034470 obo:IAO_0000115 "Elevated amount of chloride in the stool." ; dc:date "2022-12-04T15:32:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chloride high in stool", "Elevations in faecal chloride concentration", "Elevations in fecal chloride concentration" ; a owl:Class ; rdfs:label "Elevated stool chloride content" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034471 obo:IAO_0000115 "Abnormal relative increase in the amount of fecal coproporphyrin III as compared to coproporphyrin I in the feces." ; dc:date "2022-12-04T15:35:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Coproporphyrin isomer III/I ratio high in stool", "Increased faecal CIII:CI ratio", "Increased fecal CIII:CI ratio" ; a owl:Class ; rdfs:label "Increased fecal coproporphyrin III:coproporphyrin I ratio" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034472 obo:IAO_0000115 "Abnormally high concentration of harderoporphyrin in feces." ; dc:date "2022-12-04T15:39:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Harderoporphyrin high in stool" ; a owl:Class ; rdfs:label "Increased fecal harderoporphyrin" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0034473 obo:IAO_0000115 "Abnormally high concentration of heptacarboxylporphyrin in feces." ; dc:date "2022-12-04T15:41:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Heptacarboxylporphyrin high in stool" ; a owl:Class ; rdfs:label "Increased fecal heptacarboxylporphyrin" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0034474 obo:IAO_0000115 "Abnormally high concentration of pentacarboxylporphyrin in feces." ; dc:date "2022-12-04T15:42:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pentacarboxylporphyrin high in stool" ; a owl:Class ; rdfs:label "Increased fecal pentacarboxylporphyrin" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0034475 obo:IAO_0000115 "Abnormally high concentration of isocoproporphyrin in feces." ; dc:date "2022-12-04T15:43:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Isocoproporphyrin high in stool" ; a owl:Class ; rdfs:label "Increased fecal isocoproporphyrin" ; rdfs:subClassOf obo:HP_0032999 . obo:HP_0034476 obo:IAO_0000115 "Identification of Clostridium botulinum toxin in the feces." ; dc:date "2022-12-04T15:45:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Clostridium botulinum toxin in stool" ; a owl:Class ; rdfs:label "Positive fecal Clostridium botulinum test" ; rdfs:subClassOf obo:HP_0034866 . obo:HP_0034477 obo:IAO_0000115 "Abnormal union of the membranous surfaces of the liver capsule and the parietal peritoneum due to inflammation or injury. Adhesions may be visualized by laparoscopy and may have a violin string appearance." ; dc:date "2022-12-04T17:20:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peri-hepatic adhesions" ; a owl:Class ; rdfs:label "Perihepatic adhesions" ; rdfs:subClassOf obo:HP_0002585 . obo:HP_0034478 obo:IAO_0000115 "Abnormal increase in diameter (expansion) of the vas deferens." ; dc:date "2022-12-04T18:05:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vas deferens dilated" ; a owl:Class ; rdfs:label "Dilated vas deferens" ; rdfs:subClassOf obo:HP_0012872 . obo:HP_0034479 obo:IAO_0000115 "Abnormal increase in the size of the epididymis." ; dc:date "2022-12-04T18:11:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Epididymis enlarged" ; a owl:Class ; rdfs:label "Enlarged epididymis" ; rdfs:subClassOf obo:HP_0009714 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001301 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034480 dc:date "2022-12-04T18:26:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent epididymides", "Epididymides absent" ; a owl:Class ; rdfs:label "Absent epididymidis" ; rdfs:subClassOf obo:HP_0009714 . obo:HP_0034481 obo:IAO_0000115 "Spontaneous production of communicative gestures that are perceived as odd or mechanical, or are poorly integrated with other means of communication. This may include inaccurate mimicry of typical gestures." ; dc:date "2022-12-10T12:24:11Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:comment "Gestures refer to movements of the arms, hand, shoulders, or head and do not include facial expressions." ; rdfs:label "Atypical gestures" ; rdfs:subClassOf obo:HP_4000090 . obo:HP_0034482 dc:date "2022-12-10T14:01:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal spinal cord physiology" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0034483 obo:IAO_0000115 "The presence of lymphocytes with multilple vacuoles (a membrane-bound cell organelle) in the bone marrow." ; dc:date "2022-12-10T14:10:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone marrow: vacuolated lymphocytes" ; a owl:Class ; rdfs:label "Bone marrow vacuolated lymphocytes" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0034484 obo:IAO_0000115 "The presence of calcium deposition in the spinal cord." ; dc:date "2022-12-10T14:21:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spinal cord calcifications" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0034485 obo:IAO_0000115 "A benign epithelial-lined cystic lesion that can occur anywhere in the neuraxis. Neuroepithelial cysts are ependymal or epithelial lined fluid collections of unknown etiology within the central nervous system parenchyma with no obvious ventricular or subarachnoid connection. Most cysts are asymptomatic, however, some present with seizures, mass effect, or rarely with movement disorders. On imaging, they present as CSF-like parenchymal cysts with smooth, rounded borders and minimal or no surrounding signal intensity abnormality." ; dc:date "2022-12-10T14:31:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glioependymal cyst", "Neuroglial cyst" ; a owl:Class ; rdfs:label "Neuroepithelial cyst" ; rdfs:subClassOf obo:HP_0030063, obo:HP_0100835 . obo:HP_0034486 obo:IAO_0000115 "A diminished concentration of interleukin-7 in the circulation." ; dc:date "2022-12-10T14:38:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-7 low in blood" ; a owl:Class ; rdfs:label "Reduced circulating interleukin 7 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034487 obo:IAO_0000115 "An increased concentration of interleukin-12 in the blood circulation." ; dc:date "2022-12-10T14:39:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-12 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 12 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034488 obo:IAO_0000115 "An increased concentration of interleukin-13 in the blood circulation." ; dc:date "2022-12-10T14:40:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-13 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 13 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034489 obo:IAO_0000115 "An increased concentration of interleukin-2 in the blood circulation." ; dc:date "2022-12-10T14:41:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-2 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 2 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034490 obo:IAO_0000115 "An increased concentration of interleukin-4 in the blood circulation." ; dc:date "2022-12-10T14:43:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-4 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 4 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034491 obo:IAO_0000115 "An increased concentration of interleukin-5 in the blood circulation." ; dc:date "2022-12-10T14:43:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "IL-5 high in blood" ; a owl:Class ; rdfs:label "Increased circulating interleukin 5 concentration" ; rdfs:subClassOf obo:HP_0030782 . obo:HP_0034492 obo:IAO_0000115 "An inflammation of the fallopian tube." ; dc:date "2022-12-10T17:20:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Salpingitis" ; rdfs:subClassOf obo:HP_0011027 . obo:HP_0034493 obo:IAO_0000115 "A tubo-ovarian abscess (TOA) is a complex infectious mass of the adnexa that forms as a sequela of pelvic inflammatory disease." ; dc:date "2022-12-10T17:22:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Classically, a TOA manifests with an adnexal mass, fever, elevated white blood cell count, lower abdominal-pelvic pain, and/or vaginal discharge." ; rdfs:label "Tubo-ovarian abscess" ; rdfs:subClassOf obo:HP_0100592 . obo:HP_0034494 obo:IAO_0000115 "White appearance (radio-opaqueness) of a paranasal sinus on radiography." ; dc:date "2022-12-10T17:24:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Paranasal sinuses opacification", "Paranasal sinuses opacified" ; a owl:Class ; rdfs:label "Opacified paranasal sinuses" ; rdfs:subClassOf obo:HP_0000245 . obo:HP_0034495 obo:IAO_0000115 "An increased in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2022-12-10T17:27:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated brain glutamine level by MRS" ; rdfs:subClassOf obo:HP_0034496 . obo:HP_0034496 obo:IAO_0000115 "A deviation from normal in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2022-12-10T17:27:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal brain glutamine level by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0034497 obo:IAO_0000115 "The concentration of hexanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2022-12-10T17:32:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urinary hexanoic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034498 obo:IAO_0000115 "Hepatic focal nodular hyperplasia (FNH) is a benign hepatic tumor. FNH develops within hepatic parenchymal tissue that is otherwise histologically normal. Macroscopically, the tumor is characterized by the presence of depressed, grayish-white scar, which is generally (but not always) located at the center of the lesion, with fibrous septa radiating outward, toward the periphery of the tumor. This stellate scar is found in only 50% of all FNH nodules, but its presence is regarded as pathognomonic. The lesion itself is usually lighter in color than the tissue that surrounds it, and it sometimes has a yellowish hue. FNH nodules are generally not capsulated; their margins are well defined, and they are sometimes lobulated." ; dc:date "2022-12-10T17:34:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal nodular hyperplasia" ; a owl:Class ; rdfs:comment "FNH is often an incidental finding" ; rdfs:label "Hepatic focal nodular hyperplasia" ; rdfs:subClassOf obo:HP_0002896 . obo:HP_0034499 obo:IAO_0000115 "An increased amount of iron in the bone marrow." ; dc:date "2022-12-10T17:37:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone marrow: iron stores increased" ; a owl:Class ; rdfs:comment "This feature can be assessed by methods including Prussian blue staining of bone marrow smears." ; rdfs:label "Increased bone marrow iron" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0034500 obo:IAO_0000115 "A fracture of the glenoid fossa, a relatively shallow dish is located on the lateral scapula and is the socket portion of the shoulder joint that meets to articulate the humeral head." ; dc:date "2022-12-10T17:40:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Glenoid fracture" ; rdfs:subClassOf obo:HP_0041245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034501 obo:IAO_0000115 "Abnormal increase in the width of the mediastinum, often defined as being greater than 6 to 8 cm." ; dc:date "2022-12-10T17:43:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mediastinal widening" ; a owl:Class ; rdfs:comment "This feature can be ascertained by plain chest radiography. A wide mediastinum has many causes which include thoracic aortic aneurysm of the ascending and proximal descending aorta, aortic dissection of ascending and proximal descending aorta, unfolding of the aorta, traumatic aortic rupture, hilar lymphadenopathy, mediastinal masses, mediastinitis, cardiac tamponade, and fractured ribs or thoracic vertebrae." ; rdfs:label "Widened mediastinum" ; rdfs:subClassOf obo:HP_0045026 . obo:HP_0034502 obo:IAO_0000115 "Abnormal decrease in the width of the mediastinum." ; dc:date "2022-12-10T17:53:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Narrow mediastinum" ; rdfs:subClassOf obo:HP_0045026 . obo:HP_0034503 obo:IAO_0000115 "Ovarian torsion is a twisting of the ligaments that support the adnexa, cutting off the blood flow to the ovary." ; dc:date "2022-12-10T17:59:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ovarian torsion" ; rdfs:subClassOf obo:HP_0031065 . obo:HP_0034504 obo:IAO_0000115 "Septate gallbladder is characterized by the presence of a septum that divides the gallbladder in two chambers. When the septum dividing the gallbladder lies longitudinally it is called bilobed gallbladder and when there is a transverse septum separating the fundus from the rest of the gallbladder it is called an hour-glass gallbladder." ; dc:date "2022-12-10T18:01:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Septate gallbladder" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0034505 obo:IAO_0000115 "Abnormal increased in the thickness of the wall of the gallbladder." ; dc:date "2022-12-10T18:04:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Gallbladder wall thickening is a common yet nonspecific finding that can occur in a wide range of gallbladder diseases and extracholecystic conditions." ; rdfs:label "Gallbladder wall thickening" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0034506 obo:IAO_0000115 "Abnormal increased in the thickness of the size of the gallbladder." ; dc:date "2022-12-10T18:07:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gallbladder enlarged" ; a owl:Class ; rdfs:label "Gallbladder enlargement" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0034507 obo:IAO_0000115 "An abnormal lesion or swelling seen on gallbladder imaging." ; dc:date "2022-12-10T18:08:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gallbladder mass" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0034508 obo:IAO_0000115 "Fingerprint bodies are inclusion bodies located at the periphery of the muscle fibers underneath the sarcolemma (subsarcolemmal), consisting of non-membrane-bound packed lamellae arranged in concentric patterns resembling fingerprints." ; dc:date "2022-12-11T14:04:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: fingerprint bodies at periphery of muscle fibers", "Muscle biopsy: fingerprint bodies at periphery of muscle fibres" ; a owl:Class ; rdfs:comment "See Figure 2 of PMID:32008911." ; rdfs:label "Fingerprint bodies" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0034509 obo:IAO_0000115 "An accumulation of myofilamentous material within individual muscle fibers, forming usually round but occasionally elongated bodies ranging from 2 to 15 pm in size. The so-called spheroid bodies stain green with the modified trichrome preparation and are mainly present in the periphery of type 1 muscle fibers, where they may occupy large sectors sharply demarcated from the remainder of the cross-sectioned muscle fiber." ; dc:date "2022-12-11T14:16:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 3 of PMID:571956." ; rdfs:label "Spheroid bodies" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0034510 obo:IAO_0000115 "Any deviation from the normal activity or histological staining of an enzyme in muscle tissue, usually measured in a muscle biopsy specimen." ; dc:date "2022-12-11T14:21:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal muscle tissue enzyme activity or level" ; rdfs:subClassOf obo:HP_0011805 . obo:HP_0034511 obo:IAO_0000115 "Diminished activity of the enzyne aconitase in muscle tissue." ; dc:date "2022-12-11T14:22:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: aconitase deficiency" ; a owl:Class ; rdfs:label "Reduced muscle aconitase activity" ; rdfs:subClassOf obo:HP_0034510 . obo:HP_0034512 obo:IAO_0000115 "A cancer of the ureter that most often arises in the distal third of the ureter and is often diagnosed during the sixth and seventh decades of life. The most common presentation is gross hematuria or flank pain." ; dc:date "2022-12-11T14:33:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transitional-cell carcinoma of the ureter" ; rdfs:subClassOf obo:HP_0100516 . obo:HP_0034513 obo:IAO_0000115 "An elevation in the concentration of interferon alpha measured in the blood circulation." ; dc:date "2022-12-14T13:26:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Interferon-alpha high in blood" ; a owl:Class ; rdfs:label "Increased circulating Interferon-alpha concentration" ; rdfs:subClassOf obo:HP_0030354 . obo:HP_0034514 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the liver." ; dc:date "2022-12-14T13:37:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Liver hamartoma" ; rdfs:subClassOf obo:HP_0002896, obo:HP_0010566 . obo:HP_0034515 obo:IAO_0000115 "Ameloblastoma is a benign odontogenic tumor generally present in the jaw bone. The tumor originates from the residual epithelium of the tooth germ, epithelium of odontogenic cysts stratified squamous epithelium and epithelium of the enamel organ." ; dc:date "2022-12-14T13:42:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameloblastoma" ; rdfs:subClassOf obo:HP_0100612 . obo:HP_0034516 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by following a ketogenic diet." ; dc:date "2022-12-14T13:53:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ketogenic diet improves symptoms" ; a owl:Class ; rdfs:comment "The ketogenic diet is a method of nutrition leading to the increased production of ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) in the organism and, thus, to a condition of ketosis. This effect comes about by obtaining the greatest energy share from fats and minimising the consumption of carbohydrates." ; rdfs:label "Ameliorated by ketogenic diet" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034517 obo:IAO_0000115 "Darkening of the area of skin that overlies the shin." ; dc:date "2022-12-21T12:34:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pretibial hyperpigmentation" ; rdfs:subClassOf obo:HP_0000953 . obo:HP_0034518 obo:IAO_0000115 "Gums that are easily damaged." ; dc:date "2022-12-21T12:36:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Gum fragility" ; a owl:Class ; rdfs:label "Gingival fragility" ; rdfs:subClassOf obo:HP_0000168 . obo:HP_0034519 obo:IAO_0000115 "The presence of inclusion bodies within the cytoplasm of muscle cells that react positively with acid fuchsin." ; dc:date "2022-12-21T12:48:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Muscle fiber fuchsinophilic inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0034520 obo:IAO_0000115 "Deterioration of the cells of the myenteric plexus (also known as the Auerbach plexus) located between the layers of the muscular propria of the esophagus." ; dc:date "2022-12-21T12:52:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophageal myenteric plexus degeneration" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0034521 obo:IAO_0000115 "Scaling and overgrowth of horny tissue of the skin surrounding body orifices (including peri-auricular, peri-oral, peri-anal areas." ; dc:date "2023-02-06T12:37:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periorificial hyperkeratosis" ; rdfs:subClassOf obo:HP_0000962 . obo:HP_0034522 obo:IAO_0000115 "Presence of an elevated number of eosinophils in a lymph node (usually as demonstrated by lymph node biopsy)." ; dc:date "2023-02-06T12:43:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Eosinophilic lymph node infiltration" ; rdfs:subClassOf obo:HP_0034582 . obo:HP_0034523 obo:IAO_0000115 "Detection of a parasitic organism in the blood stream. Blood parasites include malaria plasmodia, microfilaria species, trypanosomes (the causative agents of African sleeping sickness and South American Changas disease) and the causative agents of schistosomiasis of the bladder and the intestine." ; dc:date "2023-02-06T12:54:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood parasite" ; rdfs:subClassOf obo:HP_0031863 . obo:HP_0034524 obo:IAO_0000115 "Presence of trypomastigote parasites in the blood stream. This finding can be demonstrated by the identification of trypomastigote parasites on peripheral blood smear." ; dc:date "2023-02-06T12:58:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bloodstream trypomastigotes" ; rdfs:subClassOf obo:HP_0034523 . obo:HP_0034525 obo:IAO_0000115 "A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns." ; dc:date "2023-02-06T13:04:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Adamantinoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0034526 obo:IAO_0000115 "Deviation from the normal activity of an enzyme in muscle tissue." ; dc:date "2023-02-08T14:28:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal enzyme activity in muscle tissue" ; rdfs:subClassOf obo:HP_0034684 . obo:HP_0034527 obo:IAO_0000115 "Reduced activity of phosphoglycerate kinase (PGK) in muscle tissue. PGK is a glycolytic enzyme that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate." ; dc:date "2023-02-08T14:29:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced muscle phosphoglycerate kinase activity" ; rdfs:subClassOf obo:HP_0034526 . obo:HP_0034528 obo:IAO_0000115 "Diminished production of type III procollagen by cultured skin fibroblasts." ; dc:date "2023-02-08T15:18:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Type III procollagen synthesis by fibroblasts low" ; a owl:Class ; rdfs:label "Reduced fibroblast type III procollagen synthesis" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0034529 obo:IAO_0000115 "Diminished activity of the enzyme myoadenylate deaminase. Myoadenylate deaminase is the muscle isoform of adenosine monophosphate (AMP) deaminase and catalyzes the deamination of AMP to inosine monophosphate and ammonia." ; dc:date "2023-02-08T15:50:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: myoadenylate deaminase low" ; a owl:Class ; rdfs:label "Reduced muscle myoadenylate deaminase activity" ; rdfs:subClassOf obo:HP_0034526 . obo:HP_0034530 obo:IAO_0000115 "A developmental defect of a long bone, such as the femur or the humerus, characterized by a sharply curve deviation located in the metaphysis (shaft) of the bone." ; dc:date "2023-02-10T13:31:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bent long bone" ; rdfs:subClassOf obo:HP_0011314 . obo:HP_0034531 obo:IAO_0000115 "A break or tear in the trachea." ; dc:date "2023-02-10T13:37:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tracheal rupture" ; rdfs:subClassOf obo:HP_0002778 . obo:HP_0034532 obo:IAO_0000115 "Elevated amount of glycogen in the myocardium." ; dc:date "2023-02-10T13:40:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased glycogen in myocardium" ; a owl:Class ; rdfs:label "Increased myocardial glycogen content" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0034533 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a monoamine oxidase inhibitor." ; dc:date "2023-02-10T13:43:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "MAO inhibitors trigger attacks", "Triggered by MAO inhibitor" ; a owl:Class ; rdfs:label "Triggered by monoamine oxidase inhibitor" ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0034534 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a serotonin reuptake inhibitor." ; dc:date "2023-02-10T13:45:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Serotonin uptake inhibitors trigger attacks" ; a owl:Class ; rdfs:label "Triggered by serotonin reuptake inhibitor" ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0034535 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with acetazolamide." ; dc:date "2023-02-10T13:47:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Acetazolamide relieves attacks" ; a owl:Class ; rdfs:label "Ameliorated by acetazolamide" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034536 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with a medication. Terms in this subhierarchy are intended to be used for cases in which the fact that a manifestation of a disease responds to a specific treatment can be used in the differential diagnosis." ; dc:date "2023-02-10T13:49:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by exposure to medication" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034537 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with vitamin B12." ; dc:date "2023-02-10T13:51:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Vitamin B12 treatment produces improvement" ; a owl:Class ; rdfs:label "Ameliorated by vitamin B12" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034538 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with thiamine." ; dc:date "2023-02-10T13:52:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thiamine: positive response" ; a owl:Class ; rdfs:label "Ameliorated by thiamine" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034539 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with dantrolene." ; dc:date "2023-02-10T13:53:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dantrolene reduces symptoms" ; a owl:Class ; rdfs:label "Ameliorated by dantrolene" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034540 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with biotin." ; dc:date "2023-02-10T13:55:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Biotin supplementation produces improvement" ; a owl:Class ; rdfs:label "Ameliorated by biotin" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034541 obo:IAO_0000115 "Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems." ; dc:date "2023-02-10T13:57:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced bone-marrow megakaryocyte size" ; rdfs:subClassOf obo:HP_0012143 . obo:HP_0034542 obo:IAO_0000115 "Long narrow depressions running lengthwise in hairshafts. This feature can be appreciated by scanning electron microsopy." ; dc:date "2023-02-10T14:59:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:11234560." ; rdfs:label "Hairshafts with longitudinal grooves" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0034543 obo:IAO_0000115 "Presence of viable mycobacteria in the blood." ; dc:date "2023-02-17T16:39:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Mycobacterium present on blood culture" ; a owl:Class ; rdfs:label "Mycobacterium bacteremia" ; rdfs:subClassOf obo:HP_0031864 . obo:HP_0034544 obo:IAO_0000115 "Reduced activity of the enzyme delta-aminolevulinate dehydratase. The enzyme is active in erythrocytes." ; dc:date "2023-02-17T16:43:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Delta-aminolevulinate dehydratase activity low", "Delta-aminolevulinate dehydratase deficiency" ; a owl:Class ; rdfs:label "Decreased delta-aminolevulinate dehydratase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034545 obo:IAO_0000115 "Increased activity of the enzyme pancreatic secretory trypsin inhibitor in the blood circulation." ; dc:date "2023-02-17T18:28:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating SPINK1 activity", "Elevated circulating serine protease inhibitor Kazal type I" ; a owl:Class ; rdfs:comment "Pancreatic secretory trypsin inhibitor (PSTI), also known as serine protease inhibitor Kazal type I (SPINK1), binds rapidly to trypsin, inhibits its activity and is likely to protect the pancreas from prematurely activated trypsinogen. The blood concentration of PSTI may be increased in hepatocellular carcinoma and as a part of the acute phase reposnse response to infection, inflammation, tissue damage and other stressors." ; rdfs:label "Elevated circulating pancreatic secretory trypsin inhibitor activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034546 obo:IAO_0000115 "A developmental anomaly in which an individual with an X chromosome and a Y chromosome (usually 46,XY) has a uterus. The uterus and Fallopian tubes are derived from the Müllerian duct and thus this phenotype is generally also associated with the presence of Fallopian tubes." ; dc:date "2023-02-19T18:25:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Presence of uterus in 46,XY individual" ; rdfs:subClassOf obo:HP_0000812 . obo:HP_0034547 obo:IAO_0000115 "Deposition of calcium in meconium present in the internal cavity of the fetal bowel. This manifestation may be the result of any distal intestinal obstruction." ; dc:date "2023-02-19T18:26:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intraluminal meconium calcification" ; rdfs:subClassOf obo:HP_0034207 . obo:HP_0034548 obo:IAO_0000115 "A developmental defect characterized by underdevelopment of hte portal vein." ; dc:date "2023-02-19T18:35:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoplasia of the portal veins" ; a owl:Class ; rdfs:label "Portal vein hypoplasia" ; rdfs:subClassOf obo:HP_0031941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034549 obo:IAO_0000115 "Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries" ; dc:date "2023-02-19T18:52:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pheochromocytoma, Cortical Carcinoma, Adrenal leiomyoma present with heterogeneously enhancing masses on different imaging modalities but cannot be differentiated solely based on imaging." ; rdfs:label "Adrenal leiomyoma" ; rdfs:subClassOf obo:HP_0100631 . obo:HP_0034550 obo:IAO_0000115 "Infiltration of the wall of the small intestine by lymphocytes and mature plasma cells." ; dc:date "2023-02-19T19:04:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small intestinal lymphoplasmacytic infiltrate" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0034551 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to neuroleptic (also known as antipsychotic) medication." ; dc:date "2023-02-19T20:19:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Triggered by antipsychotic medication" ; a owl:Class ; rdfs:label "Triggered by neuroleptic medication" ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0034552 obo:IAO_0000115 "Structural anomaly of peroxisomes, which are small, membrane-enclosed metabolic organelles with roles in the metabolism of complex lipids and reactive ionic species." ; dc:date "2023-02-19T20:27:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal peroxisomal morphology" ; rdfs:subClassOf obo:HP_0025461 . obo:HP_0034553 obo:IAO_0000115 "Lack of observable peroxisomes. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy." ; dc:date "2023-02-19T20:40:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absence of peroxisomes" ; rdfs:subClassOf obo:HP_0034552 . obo:HP_0034554 obo:IAO_0000115 "Reduced number of observable peroxisomes per cell. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy." ; dc:date "2023-02-19T20:43:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paucity of peroxisomes" ; rdfs:subClassOf obo:HP_0034552 . obo:HP_0034555 obo:IAO_0000115 "Reduced activity of the enzyme sulfide:quinone oxidoreductase, which typically is measured in a biopsy specimen from liver or muscle." ; dc:date "2023-02-19T20:46:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced sulfide:quinone oxidoreductase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034556 obo:IAO_0000115 "Refers to distribution of neurological deficits that corresponds to a deficit of a specific spinal segment and all segments below it." ; dc:date "2023-02-19T20:49:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Deficit at segmental level" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0034557 obo:IAO_0000115 "Rhabdoid tumors are rare aggressive malignancies in infants and young children with a poor prognosis. The most common anatomic localizations are the central nervous system, the kidneys, and other soft tissues." ; dc:date "2023-02-19T21:17:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rhabdoid tumor" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0034558 obo:IAO_0000115 "A highly aggressive, extremely rare neoplasm of the ovary that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers." ; dc:date "2023-02-19T21:20:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Rhabdoid tumor of the ovary" ; rdfs:subClassOf obo:HP_0034557 . obo:HP_0034559 obo:IAO_0000115 "A rare and aggressive neoplasms developing mainly in the kidney but also in cerebral and extra-cerebral tissues and rarely in the heart. Histologically, rhabdoid renal and extrarenal tumors share common characteristics. The cells are polygonal, with eccentric, vesicular nuclei and prominent nucleoli, eosinophilic cytoplasmic inclusions. The tumors have an infiltrative growth pattern, necrosis, and high proliferative index. The immunohistochemistry tools of investigation facilitate differential diagnosis by showing loss of INI-1 expression, usually accompanied by germline mutations of the SMARCB1 gene. When INI-1 is still expressed in the affected tissues, a rhabdoid tumor with SMARCA4 mutations should be considered." ; dc:date "2023-02-19T21:23:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiac rhabdoid tumor" ; rdfs:subClassOf obo:HP_0034557 . obo:HP_0034560 obo:IAO_0000115 "A rhabdoid tumor (a rare aggressive malignancies in infants and young children with a poor prognosis) originating in the urinary bladder." ; dc:date "2023-02-19T21:27:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Malignant rhabdoid tumor of the bladder" ; rdfs:subClassOf obo:HP_0034557 . obo:HP_0034561 obo:IAO_0000115 "A malginant rhabdoid tumor (MRT) originating in the liver. MRT are best characterized by the presence of round or polygonal cells with abundant eosinophilic cytoplasm, typical eosinophilic perinuclear inclusions, vesicular nuclei and prominent nucleoli. Immunohistochemical expression of vimentin and epithelial markers and lack of staining for S-100, myoglobin and desmin are commonly found, but are non-specific." ; dc:date "2023-02-19T21:31:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Malignant rhabdoid tumor of liver" ; rdfs:subClassOf obo:HP_0034557 . obo:HP_0034562 obo:IAO_0000115 "A malginant rhabdoid tumor (MRT) originating in muscle tissue." ; dc:date "2023-02-19T21:38:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Malignant rhabdoid tumor of muscle" ; rdfs:subClassOf obo:HP_0034557 . obo:HP_0034563 obo:IAO_0000115 "A teratoma located in the neck." ; dc:date "2023-02-19T21:45:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neck teratoma" ; rdfs:subClassOf obo:HP_0009792 . obo:HP_0034564 obo:IAO_0000115 "A teratoma located in a kidney." ; dc:date "2023-02-19T21:47:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Kidney teratoma" ; rdfs:subClassOf obo:HP_0009792 . obo:HP_0034565 obo:IAO_0000115 "Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis." ; dc:date "2023-02-20T13:31:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level" ; rdfs:subClassOf obo:HP_0033161 . obo:HP_0034566 obo:IAO_0000115 "A developmental anomnaly characterized by the lack of development of the posterior communicating artery." ; dc:date "2023-02-20T13:33:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence of both posterior communicating arteries" ; a owl:Class ; rdfs:comment "The posterior communicating arteries connect the internal carotid artery just proximal to its bifurcation into the anterior cerebral artery and middle cerebral artery with the posterior cerebral artery. The posterior communicating artery is part of the circle of Willis." ; rdfs:label "Aplasia of posterior communicating artery" ; rdfs:subClassOf obo:HP_0031772 . obo:HP_0034567 obo:IAO_0000115 "A developmental anomaloy characterized by congenital excavation of the optic nerve head." ; dc:date "2023-02-20T13:36:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Optic disc pit", "Optic nerve pit" ; a owl:Class ; rdfs:label "Optic pit" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0034568 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with naloxone, an opioid antagonist." ; dc:date "2023-02-20T13:40:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by naloxone" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034569 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by ingestion of pyridoxal phosphate (activated vitamin B6)." ; dc:date "2023-02-20T13:46:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by pyridoxal phosphate" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034570 obo:IAO_0000115 "Increased width of the vascular wall of portal venules within the liver." ; dc:date "2023-02-20T13:53:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The portal vein (PV) is the main vessel of the portal venous system (PVS), which drains the blood from the gastrointestinal tract, gallbladder, pancreas, and spleen to the liver. Once in the liver, the PV ramifies and reaches the sinusoids, forming portal venules." ; rdfs:label "Thickened intrahepatic portal venules" ; rdfs:subClassOf obo:HP_0031941 . obo:HP_0034571 obo:IAO_0000115 "Excessive proliferation of fibroblasts and deposition of extracellular matrix within the ovary." ; dc:date "2023-02-20T13:57:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ovarian fibrosis" ; rdfs:subClassOf obo:HP_0000137 . obo:HP_0034572 obo:IAO_0000115 "A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation." ; dc:date "2023-02-20T14:51:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pigmentary incontinence in papillary dermis" ; a owl:Class ; rdfs:label "Pigment incontinence" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0034573 dc:date "2023-02-20T15:12:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal epidermal protein expression" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034574 obo:IAO_0000115 "Amount of keratin 10 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy." ; dc:date "2023-02-20T15:12:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be assessed antibody staining of a skin biopsy specimen." ; rdfs:label "Reduced epidermal keratin 10 protein expression" ; rdfs:subClassOf obo:HP_0035004 . obo:HP_0034575 dc:date "2023-02-20T15:16:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: collagen IV antibody staining abnormal or absent" ; a owl:Class ; rdfs:comment "Lower than normal amount of collagen IV in the epidermis." ; rdfs:label "Reduced epidermal collagen IV protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034576 obo:IAO_0000115 "Lower than normal amount of bullous pemphigoid antigen 1 (BP230) in the epidermis." ; dc:date "2023-02-20T15:19:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: BPAG1-e antibody staining abnormal or absent" ; a owl:Class ; rdfs:label "Reduced epidermal bullous pemphigoid antigen 1 protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034577 dc:date "2023-02-20T15:16:43Z"^^xsd:dateTime, "2023-02-20T15:23:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: collagen VII antibody staining abnormal or absent" ; a owl:Class ; rdfs:comment "Lower than normal amount of collagen VII in the epidermis." ; rdfs:label "Reduced epidermal collagen VII protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034578 dc:date "2023-02-20T15:16:43Z"^^xsd:dateTime, "2023-02-20T15:23:48Z"^^xsd:dateTime, "2023-02-20T15:24:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: collagen XVII antibody staining abnormal or absent" ; a owl:Class ; rdfs:comment "Lower than normal amount of collagen XVII in the epidermis." ; rdfs:label "Reduced epidermal collagen XVII protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034579 dc:date "2023-02-20T15:16:43Z"^^xsd:dateTime, "2023-02-20T15:23:48Z"^^xsd:dateTime, "2023-02-20T15:24:48Z"^^xsd:dateTime, "2023-02-20T15:26:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: integrin alpha6beta4 antibody staining abnormal or absent" ; a owl:Class ; rdfs:comment "Lower than normal amount of integrin alpha6beta4 in the epidermis." ; rdfs:label "Reduced epidermal integrin alpha6beta4 protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034580 dc:date "2023-02-20T15:16:43Z"^^xsd:dateTime, "2023-02-20T15:23:48Z"^^xsd:dateTime, "2023-02-20T15:24:48Z"^^xsd:dateTime, "2023-02-20T15:26:01Z"^^xsd:dateTime, "2023-02-20T15:28:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skin biopsy: plectin antibody staining abnormal or absent" ; a owl:Class ; rdfs:comment "Lower than normal amount of plectin in the epidermis." ; rdfs:label "Reduced epidermal plectin protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034581 obo:IAO_0000115 "Presence of Trypanosoma cruzi in the blood stream. Trypanosoma cruzii is the etiological agent of Chagas disease." ; dc:date "2023-02-20T15:31:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Trypanosoma cruzi present on peripheral blood smear" ; a owl:Class ; rdfs:label "Bloodstream Trypanosoma cruzi" ; rdfs:subClassOf obo:HP_0034523 . obo:HP_0034582 obo:IAO_0000115 "A deviation from the normal distribution of cell types or their relative proprotions in a lymph node." ; dc:date "2023-02-21T00:56:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal lymph node cell composition" ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0034583 obo:IAO_0000115 "Lymph node with increased numbers of macrophages heavily laden with lipids." ; dc:date "2023-02-21T00:57:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lipid-laden lymph node macrophages" ; rdfs:subClassOf obo:HP_0034582 . obo:HP_0034584 obo:IAO_0000115 "Structural anomal of pancreatic acinus." ; dc:date "2023-02-21T01:07:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The exocrine pancreas is structurally analogous to a bunch of grapes; this architecture contains microscopic, blind-ended tubules that are surrounded by polygonal acinar cells and these tubules are organized into lobules called acini. The primary function of the acini is to synthesize and secrete hydrolytic enzymes which empty into the duodenum for the digestion of our daily foodstuff. Each acinus consists of a small cluster of secretory epithelial cells that form a small central lumen, called intercellular canaliculi. Each acinar cell has a round pyramid-like shape." ; rdfs:label "Abnormal pancreatic acinus morphology" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0034585 obo:IAO_0000115 "A developmental defect characterized by underdevelopment of the cochlear nerve." ; dc:date "2023-03-12T13:28:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cochlear nerve hypoplasia" ; rdfs:subClassOf obo:HP_0011396 . obo:HP_0034586 obo:IAO_0000115 "Level of glutathione in the urine above the upper limit of normal." ; dc:date "2023-03-12T13:31:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Glutathione high in urine" ; a owl:Class ; rdfs:label "Glutathionuria" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0034587 obo:IAO_0000115 "Nevus psiloliparus is a rare fatty tissue nevus that is a marker for encephalocraniocutaneous lipomatosis, a neurocutaneous syndrome with ocular and central nervous system anomalies. Clinically, nevus psiloliparus is often described as a congenital alopecia and appears as an irregularly shaped, circumscribed area of alopecia on the scalp. Histopathology demonstrates a near-complete absence of mature hair follicles with preservation of arrector pili muscles and mature adipocytes within the dermis." ; dc:date "2023-03-12T13:48:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nevus psiloliparus" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0034588 obo:IAO_0000115 "Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodelling." ; dc:date "2023-03-12T13:52:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Crypt hyperplasia" ; rdfs:subClassOf obo:HP_0025129 . obo:HP_0034589 obo:IAO_0000115 "Concentration of dehydroepiandrosterone-sulfate in the blood circulation above the upper limit of normal." ; dc:date "2023-03-12T13:55:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Dehydroepiandrosterone (DHEA) is produced in the adrenal glands and to a lesser extent by the ovaries and testes. DHEA is metabolized into DHEA-S in the adrenal glands and liver. Dehydroepiandrosterone-sulfate is a precursor of testosterone and estrogen." ; rdfs:label "Increased circulating dehydroepiandrosterone-sulfate concentration" ; rdfs:subClassOf obo:HP_0500022 . obo:HP_0034590 obo:IAO_0000115 "Any deviation from the normal concentration of thyroxine-binding globulin (TBG) in the blood circulation." ; dc:date "2023-03-12T14:01:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating thyroxine-binding globulin concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034591 obo:IAO_0000115 "A reduction from the normal concentration of thyroxine-binding globulin (TBG) in the blood circulation." ; dc:date "2023-03-12T14:06:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thyroxine-binding globulin low in blood" ; a owl:Class ; rdfs:label "Decreased circulating thyroxine-binding globulin concentration" ; rdfs:subClassOf obo:HP_0034590 . obo:HP_0034592 obo:IAO_0000115 "An increased concentration of beta-aminoisobutyric acid in the blood circulation." ; dc:date "2023-03-12T14:17:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Beta-aminoisobutyric acid high in blood" ; a owl:Class ; rdfs:label "Elevated circulating beta-aminoisobutyric acid concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034593 obo:IAO_0000115 "An increased concentration of dihydrouracil in the blood circulation. Dihydrouracil is an intermediate in the catabolism of uracil that is also known as 5,6-dihydrouracil." ; dc:date "2023-03-12T14:21:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dihydrouracil high in blood", "Elevated circulating 5,6-dihydrouracil concentration" ; a owl:Class ; rdfs:label "Elevated circulating dihydrouracil concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0034594 obo:IAO_0000115 "An increased concentration of dihydrothymine in the blood circulation. Dihydrouracil is an intermediate in the catabolism of thymine." ; dc:date "2023-03-12T14:25:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dihydrothymine high in blood" ; a owl:Class ; rdfs:label "Elevated circulating dihydrothymine concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0034595 obo:IAO_0000115 "An increased concentrationof N-carbamyl-beta-alanine in the blood circulation." ; dc:date "2023-03-12T14:28:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "N-carbamyl-beta-aminoisobutyric acid high in blood" ; a owl:Class ; rdfs:label "Elevated circulating N-carbamyl-beta-alanine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034596 obo:IAO_0000115 "An increased concentration of 5-hydroxymethyluracil in the blood circulation." ; dc:date "2023-03-12T14:31:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "5-hydroxymethyluracil high in blood" ; a owl:Class ; rdfs:label "Elevated ciculating 5-hydroxymethyluracil concentration" ; rdfs:subClassOf obo:HP_0004353 . obo:HP_0034597 obo:IAO_0000115 "Concentration of creatinine in the cerebrrospinal fluid below the lower limit of normal." ; dc:date "2023-03-12T14:41:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased CSF creatinine concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034598 obo:IAO_0000115 "An increased amount of creatine in the urine." ; dc:date "2023-03-12T14:45:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Creatine high in urine" ; a owl:Class ; rdfs:label "Elevated urinary creatine level" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0034599 obo:IAO_0000115 "Concentration of biotin in the blood circulation below the lower limit of normal." ; dc:date "2023-03-12T14:48:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Biotin low in blood" ; a owl:Class ; rdfs:label "Decreased circulating biotin concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034600 obo:IAO_0000115 "Concentration of thrombopoietin in the blood circulation above the upper limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes." ; dc:date "2023-03-12T18:02:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Thrombopoietin high in blood" ; a owl:Class ; rdfs:label "Elevated circulating thrombopoietin concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034601 obo:IAO_0000115 "Concentration or activity of the C1q protein in the blood circulation below the lower limit of normal. C1q is the first component of the classical pathway and is composed of the C1qA chain, C1qB chain, and C1qC chain, which are encoded by C1qA, C1qB, and C1qC genes." ; dc:date "2023-03-12T18:06:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating C1q concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0034602 obo:IAO_0000115 "Concentration of apolipoprotein A-II below the lower limit of normal." ; dc:date "2023-03-12T18:21:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Apolipoprotein A-II low in blood" ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein A-II concentration" ; rdfs:subClassOf obo:HP_0033459 . obo:HP_0034603 obo:IAO_0000115 "Concentration of CA19-9 above the upper limit of normal." ; dc:date "2023-03-12T18:26:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating cancer antigen 19-9 concentration", "Elevated circulating carbohydrate antigen 19-9 concentration", "Elevated circulating sialylated Lewis a antigen concentration" ; a owl:Class ; rdfs:comment "CA19-9 (carbohydrate antigen 19-9, also called cancer antigen 19-9 or sialylated Lewis a antigen) is the most commonly used and best validated serum tumor marker for pancreatic cancer diagnosis in symptomatic patients and for monitoring therapy in patients with pancreatic adenocarcinoma." ; rdfs:label "Elevated circulating CA19-9 concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034604 obo:IAO_0000115 "Concentration of DOPA (3,4-dihydroxyphenylalanine) in the blood circulation above the upper limit of normal." ; dc:date "2023-03-12T18:33:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "DOPA high in blood", "Elevated circulating 3,4-dihydroxyphenylalanine concentration" ; a owl:Class ; rdfs:label "Elevated circulating DOPA concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0034605 obo:IAO_0000115 "Concentration of DOPA (3,4-dihydroxyphenylalanine) in the cerebrospinal fluid above the upper limit of normal." ; dc:date "2023-03-12T18:36:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF 3,4-dihydroxyphenylalanine concentration" ; a owl:Class ; rdfs:label "Elevated CSF DOPA concentration" ; rdfs:subClassOf obo:HP_0500183 . obo:HP_0034606 obo:IAO_0000115 "Concentration of porphyrins or of a specific porphryin above the upper limit of normal. The most commonly tested circulating porphyrins are coproporphyrin, protoporphyrin, and uroporphyrin. Normally protoporphyrin is present in the highest concentration." ; dc:date "2023-03-12T18:39:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Porphyrin high in blood" ; a owl:Class ; rdfs:label "Elevated circulating porphyrin concentration" ; rdfs:subClassOf obo:HP_0010472 . obo:HP_0034607 obo:IAO_0000115 "Concentration of 17-hydroxyprogesterone in the blood circulation below the lower limit of normal." ; dc:date "2023-03-12T18:43:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating 17-hydroxyprogesterone concentration" ; rdfs:subClassOf obo:HP_0008233 . obo:HP_0034608 obo:IAO_0000115 "Concentration of transcobalamin II in the blood circulation below the lower limit of normal." ; dc:date "2023-03-12T18:45:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Transcobalamin II low in blood" ; a owl:Class ; rdfs:label "Decreased circulating transcobalamin II concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034609 obo:IAO_0000115 "Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia." ; dc:date "2023-03-12T18:47:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Polychromasia on peripheral blood smear" ; a owl:Class ; rdfs:label "Polychromasia" ; rdfs:subClassOf obo:HP_0004312 . obo:HP_0034610 obo:IAO_0000115 "Concentration of myo-inositol in the blood circulation below the lower limit of normal." ; dc:date "2023-03-13T11:30:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myoinositol low in blood" ; a owl:Class ; rdfs:label "Decreased circulating myo-inositol concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0034611 obo:IAO_0000115 "Concentration of arabitol in the blood circulation above the upper limit of normal." ; dc:date "2023-03-13T11:35:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating D-arabinitol concentration" ; a owl:Class ; rdfs:label "Elevated circulating arabitol concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0034612 obo:IAO_0000115 "Amount of arabitol in the urine above the upper limit of normal." ; dc:date "2023-03-13T11:37:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Arabitol high in urine" ; a owl:Class ; rdfs:label "Elevated urine arabitol level" ; rdfs:subClassOf obo:HP_0031979 . obo:HP_0034613 obo:IAO_0000115 "Amount of erythritol in the urine above the upper limit of normal." ; dc:date "2023-03-13T11:40:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Erythritol high in urine" ; a owl:Class ; rdfs:label "Elevated urine erythritol level" ; rdfs:subClassOf obo:HP_0031979 . obo:HP_0034614 obo:IAO_0000115 "Concentration of erythritol in the blood circulation above the upper limit of normal." ; dc:date "2023-03-13T11:41:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Erythritol high in blood" ; a owl:Class ; rdfs:label "Elevated circulating erythritol concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0034615 obo:IAO_0000115 "Concentration of matrix metalloproteinase 2 in the blood circulation below the lower limit of normal." ; dc:date "2023-03-13T11:55:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced circulating matrix metalloproteinase 2 concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034616 obo:IAO_0000115 "Concentration of a coenzyme (an organic molecule that binds to the active sites of an enzyme to promote the catalysis of a reaction) is above or below the limits of normal." ; dc:date "2023-03-13T12:31:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating coenzyme concentration" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0034617 obo:IAO_0000115 "Concentration of S-adenosyl methionine (SAM) in the blood circulation above the upper limit of normal. SAM is a cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation." ; dc:date "2023-03-13T12:35:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "S-adenosylmethionine high in blood" ; a owl:Class ; rdfs:label "Elevated circulating S-adenosyl methionine concentration" ; rdfs:subClassOf obo:HP_0034616 . obo:HP_0034618 obo:IAO_0000115 "Concentration of membrane cofactor protein in the blood circulation outside the limits of normal. Membrane cofactor protein (MCP, CD46) is a cell surface complement regulatory protein which acts as a cofactor for the factor I-mediated cleavage of the activated complement components C3b/C4b." ; dc:date "2023-03-13T12:43:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating membrane cofactor protein concentration" ; rdfs:subClassOf obo:HP_0010876 . obo:HP_0034619 obo:IAO_0000115 "Concentration of membrane cofactor protein in the blood circulation below the lower limit of normal." ; dc:date "2023-03-13T12:44:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating CD46 concentration", "MCP (membrane cofactor protein) low in blood" ; a owl:Class ; rdfs:label "Decreased circulating membrane cofactor protein concentration" ; rdfs:subClassOf obo:HP_0034618 . obo:HP_0034620 obo:IAO_0000115 "Concentration of membrane cofactor protein in the blood circulation above the upper limit of normal." ; dc:date "2023-03-13T12:45:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating CD46 concentration" ; a owl:Class ; rdfs:label "Elevated circulating membrane cofactor protein concentration" ; rdfs:subClassOf obo:HP_0034618 . obo:HP_0034621 obo:IAO_0000115 "Lipid deposits localized within the liver. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T12:47:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hepatic xanthomas" ; a owl:Class ; rdfs:label "Hepatic xanthomatosis" ; rdfs:subClassOf obo:HP_0410042 . obo:HP_0034622 obo:IAO_0000115 "Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T12:51:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Adrenal xanthomas" ; a owl:Class ; rdfs:label "Adrenal xanthomatosis" ; rdfs:subClassOf obo:HP_0011732 . obo:HP_0034623 obo:IAO_0000115 "Lipid deposits localized within the spleen. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T12:53:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spleen xanthomas" ; a owl:Class ; rdfs:label "Splenic xanthomatosis" ; rdfs:subClassOf obo:HP_0025408 . obo:HP_0034624 obo:IAO_0000115 "Lipid deposits localized within the spinal cord. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T12:58:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spinal cord xanthomas" ; a owl:Class ; rdfs:label "Spinal cord xanthomatosis" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0034625 obo:IAO_0000115 "Lipid deposits localized within the brain. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T13:00:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Brain xanthomas", "Brain xanthomata" ; a owl:Class ; rdfs:label "Brain xanthomatosis" ; rdfs:subClassOf obo:HP_0012443 . obo:HP_0034626 obo:IAO_0000115 "Lipid deposits localized within the lung. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T13:02:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lung xanthoma", "Pulmonary xanthoma" ; a owl:Class ; rdfs:label "Pulmonary xanthomatosis" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_0034627 obo:IAO_0000115 "Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T13:05:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone marrow xanthomas" ; a owl:Class ; rdfs:label "Bone marrow xanthomatosis" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0034628 obo:IAO_0000115 "Lipid deposits localized within one or more lymph nodes. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." ; dc:date "2023-03-19T13:07:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lymph node xanthomas" ; a owl:Class ; rdfs:label "Lymph node xanthomatosis" ; rdfs:subClassOf obo:HP_0002733 . obo:HP_0034629 obo:IAO_0000115 "Xanthoma of bone is an exceedingly rare benign primary bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells." ; dc:date "2023-03-19T13:09:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone xanthoma" ; a owl:Class ; rdfs:comment "Because of the aggressive radiographic appearance of bone xanthoma, other primary bone tumors and metastatic lesions need to be ruled out." ; rdfs:label "Xanthoma of bone" ; rdfs:subClassOf obo:HP_0011842 . obo:HP_0034630 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with folinic acid." ; dc:date "2023-03-19T13:16:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ameliorated by leucovorin" ; a owl:Class ; rdfs:label "Ameliorated by folinic acid" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034631 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a succinylcholine anesthetic such as suxamethonium." ; dc:date "2023-03-19T13:19:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasNarrowSynonym "Triggered by suxamethonium" ; a owl:Class ; rdfs:label "Triggered by succinylcholine anesthetic" ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0034632 obo:IAO_0000115 "History of having been treated with an exogenous androgen medication." ; dc:date "2023-03-19T13:22:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Androgen exposure, exogenous" ; a owl:Class ; rdfs:label "Exogenous androgen exposure" ; rdfs:subClassOf obo:HP_4000112 . obo:HP_0034633 obo:IAO_0000115 "Diminished activity of the enzyme enolase in muscle tissue. The enzyme enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. In adult human muscle, over 90% of enolase activity is accounted for by the beta-enolase subunit, the protein product of the ENO3 gene." ; dc:date "2023-03-19T13:25:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: beta-enolase activity low" ; a owl:Class ; rdfs:label "Reduced muscle enolase activity" ; rdfs:subClassOf obo:HP_0034526 . obo:HP_0034634 obo:IAO_0000115 "History of having been treated with a dopamine antagonist including metaclopramide, phenothiazine; haloperidol, chlorpromazine, promethazine, prochlorperazine, ziprasidone, and quetiapine." ; dc:date "2023-03-19T13:29:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dopamine antagonist treatment history" ; a owl:Class ; rdfs:label "Dopamine antagonist exposure" ; rdfs:subClassOf obo:HP_4000112 . obo:HP_0034635 obo:IAO_0000115 "The presence of inclusion bodies within the cytoplasm of muscle cells that contain a mxiture of granules and filaments." ; dc:date "2023-03-19T14:14:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 7B of PMID:19181099." ; rdfs:label "Muscle fiber granulofilamentous inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0034636 obo:IAO_0000115 "Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow." ; dc:date "2023-03-19T14:18:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone marrow: myeloid vacuolization", "Vacuolization of bone marrow myeloid precursors" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:33690844." ; rdfs:label "Bone marrow myeloid vacuolization" ; rdfs:subClassOf obo:HP_0012130 . obo:HP_0034637 obo:IAO_0000115 "A cylindroma located in the lung. Cylindromas are well-circumscribed, smooth, pale pink nodular tumors, often with arborizing vessels visible. The tumors are slow growing and vary in size from a few millimeters to over 5 mm." ; dc:date "2023-03-19T14:23:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:29569226." ; rdfs:label "Pulmonary cylindroma" ; rdfs:subClassOf obo:HP_0100526 . obo:HP_0034638 obo:IAO_0000115 "Fluid visible on the colonic surface containing fibrin, inflammatory cells, and cellular debris." ; dc:date "2023-03-19T14:31:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Colonic fibrinopurulent exudate" ; rdfs:subClassOf obo:HP_0002250 . obo:HP_0034639 obo:IAO_0000115 "Presence of filaria in the blood stream. Filariasis is a common cause of elephantiasis in Coastal Districts of India. The initial manifestations are repeated episodes of fever with chills and rigor, lymphadenopathy which gradually progress to elephantiasis. In India filarial infestation is commonly caused by W. bancrofti and Brugia malayi, the former responsible for almost 98 percent of all cases." ; dc:date "2023-03-19T14:37:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Filariasis is an infectious parasitic disease caused by roundworms that belong to the family Filarioidea. These are spread by bloodfeeding insects such as black flies and mosquitoes. Eight known filarial nematodes use humans as their definitive hosts. See Figure 1 of PMID:32313484." ; rdfs:label "Bloodstream microfilaria" ; rdfs:subClassOf obo:HP_0034523 . obo:HP_0034640 obo:IAO_0000115 "The presence of an infectious agent in the skin." ; dc:date "2023-03-19T15:02:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Skin infectious agent" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0034641 obo:IAO_0000115 "Presence of filariae in the skin." ; dc:date "2023-03-19T15:03:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dermal microfilariae" ; a owl:Class ; rdfs:label "Dermal microfilaria" ; rdfs:subClassOf obo:HP_0034640 . obo:HP_0034642 obo:IAO_0000115 "Accumulation of immunoglobulin A (IgA) surrounding dermal papillae, which are specialized cells that support the hair follicle." ; dc:date "2023-03-19T15:12:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Granular IgA deposits at the dermal papillae" ; a owl:Class ; rdfs:label "Dermal papillary IgA deposition" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034643 obo:IAO_0000115 "Accumulation of antigen-bound antibody in the skin." ; dc:date "2023-03-19T15:26:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dermal immune complex deposition" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0034644 obo:IAO_0000115 "The concentration of a metabolite in the liver is above or below the limits of normal." ; dc:date "2023-03-19T15:38:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal liver metabolite concentration" ; rdfs:subClassOf obo:HP_0032243, obo:HP_0410042 . obo:HP_0034645 obo:IAO_0000115 "Intracellular accumulation of polyglucosan bodies-containing amylopectinlike polysaccharide-in the liver." ; dc:date "2023-03-19T15:40:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Accumulation of polyglucosan bodies in the liver" ; a owl:Class ; rdfs:label "Hepatic polyglucosan accumulation" ; rdfs:subClassOf obo:HP_0031137 . obo:HP_0034646 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) located in the urinary bladder." ; dc:date "2023-03-19T15:47:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bladder neurofibroma" ; a owl:Class ; rdfs:label "Urinary bladder neurofibroma" ; rdfs:subClassOf obo:HP_0009725 . obo:HP_0034647 obo:IAO_0000115 "An aggregation of macrophages (forming in response to chronic inflammation) localized in the lining of a joint (synovium)." ; dc:date "2023-03-19T15:52:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Synovial granuloma" ; rdfs:subClassOf obo:HP_0005262 . obo:HP_0034648 obo:IAO_0000115 "The concentration of fumaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-03-21T11:43:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urine fumarate level" ; a owl:Class ; rdfs:label "Elevated urine fumaric acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034649 obo:IAO_0000115 "Amoutn of N-acetylaspartate high in the urine above upper limit of normal." ; dc:date "2023-03-21T11:50:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "N-acetylaspartate high in urine" ; a owl:Class ; rdfs:label "Elevated urine N-acetylaspartic acid level" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0034650 obo:IAO_0000115 "Level of suberylglycine in urine above upper limit of normal." ; dc:date "2023-03-21T12:00:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Suberylglycine high in urine" ; a owl:Class ; rdfs:label "Elevated urine suberylglycine level" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0034651 obo:IAO_0000115 "Level of phenylpropionylglycine in urine above upper limit of normal." ; dc:date "2023-03-21T12:01:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Phenylpropionylglycine present in urine" ; a owl:Class ; rdfs:label "Elevated urine phenylpropionylglycine level" ; rdfs:subClassOf obo:HP_0031980 . obo:HP_0034652 obo:IAO_0000115 "The concentration of octenedioic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-03-21T12:05:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Octenedioic acid high in urine" ; a owl:Class ; rdfs:label "Elevated urine octenedioic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034653 obo:IAO_0000115 "Level of a monocarboxylic acid in the urine above the upper limit of normal. A monocarboxylic acid is an oxoacid containing one carboxy group." ; dc:date "2023-03-21T12:09:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Monocarboxylic aciduria" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034654 obo:IAO_0000115 "Amount of octanoic acid in the urine above the upper limit of normal." ; dc:date "2023-03-21T12:11:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine octanoic acid level" ; rdfs:subClassOf obo:HP_0034653 . obo:HP_0034655 obo:IAO_0000115 "The concentration of glutaconic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-03-21T12:13:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine glutaconic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034656 obo:IAO_0000115 "The concentration of 3-hydroxyglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-03-21T12:14:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "3-hydroxyglutaric acid high in urine" ; a owl:Class ; rdfs:label "Elevated urine 3-hydroxyglutaric level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034657 obo:IAO_0000115 "The concentration of malonic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-03-21T12:16:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Malonic acid present in urine" ; a owl:Class ; rdfs:label "Elevated urine malonic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034658 obo:IAO_0000115 "Amount of propionylglycine in the urine above the upper limit of normal." ; dc:date "2023-03-21T12:20:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine propionylglycine level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034659 obo:IAO_0000115 "Amount of tiglylglycine in the urine above upper limit of normal." ; dc:date "2023-03-21T12:21:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine tiglylglycine level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034660 obo:IAO_0000115 "Amount of 2-methylacetoacetic acid in the urine above upper limit of normal." ; dc:date "2023-03-21T12:23:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2-methylacetoacetic acid present in urine" ; a owl:Class ; rdfs:label "Elevated urine 2-methylacetoacetic acid level" ; rdfs:subClassOf obo:HP_0034653 . obo:HP_0034661 obo:IAO_0000115 "Amount of 3-hydroxypropionic acid in the urine above the upper limit of normal." ; dc:date "2023-03-21T12:24:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "3-hydroxypropionic acid high in urine" ; a owl:Class ; rdfs:label "Elevated urine 3-hydroxypropionic acid level" ; rdfs:subClassOf obo:HP_0034653 . obo:HP_0034662 obo:IAO_0000115 "Amount of 2-methylcitric acid in the urine above the upper limit of normal." ; dc:date "2023-03-21T12:26:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2-methylcitric acid high in urine", "Elevated urine 2-methylcitrate level" ; a owl:Class ; rdfs:label "Elevated urine 2-methylcitric acid level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034663 obo:IAO_0000115 "Amount of 4-hydroxyisovaleric acid in urine above upper limit of normal." ; dc:date "2023-03-21T12:28:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "4-hydroxyisovaleric acid present in urine" ; a owl:Class ; rdfs:label "Elevated urine 4-hydroxyisovaleric acid level" ; rdfs:subClassOf obo:HP_0034653 . obo:HP_0034664 obo:IAO_0000115 "Amount of 2-hydroxy-3-methylvaleric acid in the urine above the upper limit of normal. 2-Hydroxy-3-methylpentanoic acid or 2-hydroxy-3-methylvaleric acid (HMVA) is an organic acid generated by L-isoleucine metabolism." ; dc:date "2023-03-21T12:33:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "2-hydroxy-3-methylvaleric acid high in urine" ; a owl:Class ; rdfs:comment "2-hydroxy-3-methylvaleric acid is elevated in individuals with mapel syrup urine disease." ; rdfs:label "Elevated urine 2-hydroxy-3-methylvaleric acid level" ; rdfs:subClassOf obo:HP_0040156 . obo:HP_0034665 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the shoulder joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." ; dc:date "2023-03-25T12:27:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Shoulder contracture" ; rdfs:subClassOf obo:HP_0003043, obo:HP_0100360 . obo:HP_0034666 obo:IAO_0000115 "Lack of the full expected passive range of flexion of the shoulder joint (Shoulder flexion puts the arms from a resting position at one's sides to straight above the head; thus, with shoulder extension contracture it is not possible to raise the arms above the head fully)." ; dc:date "2023-03-25T12:35:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Shoulder extension contracture" ; rdfs:subClassOf obo:HP_0034665 . obo:HP_0034667 obo:IAO_0000115 "Movement in the sagittal plane that increases the angle of the thumb joint (straightens the joint); motion involving posterior bending of the vertebral column or returning to the upright position from a flexed position." ; dc:date "2023-03-25T13:02:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thumb extension contracture" ; rdfs:subClassOf obo:HP_0009600 . obo:HP_0034668 obo:IAO_0000115 "A myxoma (benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation) localized in the tongue." ; dc:date "2023-03-25T13:10:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tongue myxoma" ; rdfs:subClassOf obo:HP_0030809 . obo:HP_0034669 obo:IAO_0000115 "A structural abnormality of the knee joint or surrounding structures." ; dc:date "2023-03-25T13:22:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal knee morphology" ; rdfs:subClassOf obo:HP_0002815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034670 obo:IAO_0000115 "A functional anomaly of the knee joint." ; dc:date "2023-03-25T13:23:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal knee physiology" ; rdfs:subClassOf obo:HP_0002815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034671 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the knee joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." ; dc:date "2023-03-25T13:24:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Contracture of knee", "Contracture of the knees", "Knee contractures" ; a owl:Class ; rdfs:label "Knee contracture" ; rdfs:subClassOf obo:HP_0034669 . obo:HP_0034672 obo:IAO_0000115 "A type of knee joint contracture in which the knee lacks full expected flexion, such that the upper and lower leg cannot be brought together." ; dc:date "2023-03-25T13:25:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Knee extension contracture" ; rdfs:subClassOf obo:HP_0034671 . obo:HP_0034673 obo:IAO_0000115 "A structural anomaly of the ankle." ; dc:date "2023-03-25T13:30:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ankle morphology" ; rdfs:subClassOf obo:HP_0003028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034674 obo:IAO_0000115 "A functional anomaly of the ankle." ; dc:date "2023-03-25T13:31:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ankle physiology" ; rdfs:subClassOf obo:HP_0003028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034675 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a toe joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." ; dc:date "2023-03-26T15:48:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Toe joint contracture" ; rdfs:subClassOf obo:HP_0001780 . obo:HP_0034676 obo:IAO_0000115 "A type of toe joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together." ; dc:date "2023-03-26T15:49:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extension contracture of toe" ; rdfs:subClassOf obo:HP_0034675 . obo:HP_0034677 dc:date "2023-03-26T15:52:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ankle contracture" ; rdfs:subClassOf obo:HP_0008366, obo:HP_0034673 . obo:HP_0034678 dc:date "2023-03-26T15:53:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Forefoot pronation contracture" ; rdfs:subClassOf obo:HP_0034677 . obo:HP_0034679 dc:date "2023-03-26T15:53:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Forefoot supination contracture" ; rdfs:subClassOf obo:HP_0034677 . obo:HP_0034680 dc:date "2023-03-26T15:53:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Forefoot adduction contracture" ; rdfs:subClassOf obo:HP_0034677 . obo:HP_0034681 obo:IAO_0000115 "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a finger joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." ; dc:date "2023-03-26T16:07:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Finger joint contracture" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0009473 . obo:HP_0034682 obo:IAO_0000115 "A type of finger joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together." ; dc:date "2023-03-26T16:10:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extension contracture of finger" ; rdfs:subClassOf obo:HP_0034681 . obo:HP_0034683 obo:IAO_0000115 "Amount of telethonin protein expression in muscle tissue below lower limit of normal. Telethonin is a 19-kDa sarcomeric protein, localized to the Z-disc of skeletal and cardiac muscles." ; dc:date "2023-03-26T16:23:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: telethonin low or absent" ; a owl:Class ; rdfs:label "Reduced muscle telethonin level" ; rdfs:subClassOf obo:HP_0030089 . obo:HP_0034684 obo:IAO_0000115 "Concentration or activity of an enzyme is above or below the limits of normal." ; dc:date "2023-03-26T18:12:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal enzyme concentration or activity" ; rdfs:subClassOf obo:HP_0001939 . obo:HP_0034685 obo:IAO_0000115 "Concentration or activity of an enzyme is above or below the limits of normal in liver tissue." ; dc:date "2023-03-26T18:13:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal hepatic enzyme activity or concentration" ; a owl:Class ; rdfs:label "Abnormal liver enzyme activity or concentration" ; rdfs:subClassOf obo:HP_0034684 . obo:HP_0034686 obo:IAO_0000115 "Activity of urocanase in the liver below the lower limit of normal." ; dc:date "2023-03-26T18:13:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Liver biopsy: urocanase activity low" ; a owl:Class ; rdfs:label "Reduced hepatic urocanase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034687 obo:IAO_0000115 "Reduced hydrolysis (splitting of a bond and the addition of the hydrogen anion of water) of the sulfuric ester linkage in the molecule of cerebroside sulfate, possibly leading to accumuation of cerebroside sulfate." ; dc:date "2023-03-26T18:17:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be assayed by cerebroside sulfate loading tests of cultured dermal fibroblasts." ; rdfs:label "Impaired cerebroside sulfate hydrolysis" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0034688 obo:IAO_0000115 "Diminished enzyme activity of peroxisomal glutaryl-CoA oxidase, an enzyme that metabolizes glutaryl-CoA (a metabolite of L-lysine, L-hydroxy-lysine and L-tryptophan) by dehydrogenation to glutaconyl-CoA directly followed by decarboxylation of this to crotonyl-CoA." ; dc:date "2023-03-26T18:20:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced peroxisomal glutaryl-CoA oxidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034689 obo:IAO_0000115 "Diminished activity of the enzyme sterol 27-hydroxylase, which participates in the degradation of cholesterol to bile acid. Sterol 27-hydroxylase catalyzes the first step in the normal oxidation of the steroid side chain, converting cholesterol, as well as different 7a-hydroxylated cholesterol metabolites, to 27-oxygenated steroids." ; dc:date "2023-03-26T18:22:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced sterol 27-hydroxylase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034690 obo:IAO_0000115 "Diminished activbity of the enzyme Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid beta-oxidation that catalyses the first step in mitochondrial beta-oxidation of fatty acids." ; dc:date "2023-03-26T18:24:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced short-chain acyl-CoA dehydrogenase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034691 obo:IAO_0000115 "Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+." ; dc:date "2023-03-26T18:26:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced 3-phosphoglycerate dehydrogenase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034692 obo:IAO_0000115 "Increase in length of mitochondria." ; dc:date "2023-03-26T18:27:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Mitochondrial elongation can be initiated by a gradual merge of the outer mitochondrial membranes of two individual mitochondria." ; rdfs:label "Elongated mitochondria" ; rdfs:subClassOf obo:HP_0012087 . obo:HP_0034693 obo:IAO_0000115 "Activity of methionine adenosyltransferase in the liver below the lower limit of normal. Note that there are multiple methionine adenosyltransferase isoezymes." ; dc:date "2023-04-09T17:13:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic methionine adenosyltransferase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034694 obo:IAO_0000115 "Degeneration and loss of neruons in the substantia nigra of the brain." ; dc:date "2023-04-09T17:19:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Substantia nigra dopaminergic neuron loss" ; rdfs:subClassOf obo:HP_0045007 . obo:HP_0034696 obo:IAO_0000115 "A lipoma that is located within a muscle." ; dc:date "2023-04-15T11:17:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intramuscular lipoma" ; rdfs:subClassOf obo:HP_0012032, obo:HP_0031460 . obo:HP_0034697 obo:IAO_0000115 "Dilated blood vessels on the skin." ; dc:date "2023-04-15T11:19:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cutaneous telangiectasia" ; rdfs:subClassOf obo:HP_0001009 . obo:HP_0034698 obo:IAO_0000115 "Aromatase activity outside of the normal range." ; dc:date "2023-04-15T11:23:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone." ; rdfs:label "Abnormal aromatase activity" ; rdfs:subClassOf obo:HP_0034684 . obo:HP_0034699 obo:IAO_0000115 "Enzyme activity of aromatase above the upper limit of normal." ; dc:date "2023-04-15T11:47:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated aromatase activity" ; rdfs:subClassOf obo:HP_0034698 . obo:HP_0034700 obo:IAO_0000115 "Enzyme activity of aromatase below the lower limit of normal." ; dc:date "2023-04-15T11:49:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced aromatase activity" ; rdfs:subClassOf obo:HP_0034698 . obo:HP_0034701 obo:IAO_0000115 "A form of amyloidosis that is located in the cornea." ; dc:date "2023-04-15T11:50:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Corneal amyloidosis" ; rdfs:subClassOf obo:HP_0011034 . obo:HP_0034702 obo:IAO_0000115 "Any structural anomaly of the keratinocyte. The keratinocyte is the major cell type of the epidermis and is responsible for generating the protective barrier." ; dc:date "2023-04-15T12:02:18Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal keratinocyte morphology" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034703 obo:IAO_0000115 "Increased number of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in keratinocytes." ; dc:date "2023-04-15T12:09:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Keratinocyte vacuolation", "Vacuolated keratinocytes" ; a owl:Class ; rdfs:label "Keratinocyte vacuolization" ; rdfs:subClassOf obo:HP_0034702 . obo:HP_0034704 obo:IAO_0000115 "An adenocarcinoma that arises from the parotid gland." ; dc:date "2023-04-15T12:19:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Parotid gland adenocarcinoma" ; rdfs:subClassOf obo:HP_0012288 . obo:HP_0034705 obo:IAO_0000115 "Cellular inflammation, vessel destruction, and tissue necrosis of the blood vessels of the lung." ; dc:date "2023-04-15T12:25:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lung biopsy: vasculitis" ; a owl:Class ; rdfs:label "Pulmonary vasculitis" ; rdfs:subClassOf obo:HP_0034784 . obo:HP_0034706 obo:IAO_0000115 "Activity of D-glycerate kinase in the liver below the lower limit of normal." ; dc:date "2023-04-15T12:30:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic D-glycerate kinase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034707 obo:IAO_0000115 "Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages in a lymph node." ; dc:date "2023-04-15T19:21:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:16859547." ; rdfs:label "Lymph-node hemophagocytosis" ; rdfs:subClassOf obo:HP_0012156 . obo:HP_0034708 obo:IAO_0000115 "Underdevelopment of the upper branch of the pubis bone (inferior pubic ramus)." ; dc:date "2023-04-16T12:07:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Superior pubic ramus hypoplasia" ; rdfs:subClassOf obo:HP_0008830 . obo:HP_0034709 obo:IAO_0000115 "A rare benign mullerian mixed tumor of the uterus composed of benign epithelial and mesenchymal components." ; dc:date "2023-04-16T12:10:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine adenofibroma" ; rdfs:subClassOf obo:HP_0010784 . obo:HP_0034710 obo:IAO_0000115 "A benign malformation of the lung that includes an abnormal mixture of tissue components such as cartilage, epithelium, fat, or muscle which are common to the lung but without preservation of the organ architecture." ; dc:date "2023-04-16T12:16:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary hamartoma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100526 . obo:HP_0034711 obo:IAO_0000115 "An abnormal histological finding characterized by an increase in the cross-section area of peripheral nerve axons (up to 20-25 micrometers in diameter)." ; dc:date "2023-04-16T15:04:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In giant axonal neuropathy, distended axons are observed in conjunction with thin myelin sheaths. Distended axons may be filled with masses of neurofilaments. See Figures 4 and 5 of PMID:15897506." ; rdfs:label "Peripheral axonal distension" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0034712 obo:IAO_0000115 "Activity of the enzyme alpha-mannosidase below the lower limit of normal." ; dc:date "2023-04-16T15:07:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased alpha-mannosidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034713 obo:IAO_0000115 "A structural anomaly of the hepatocyte, which is the main cell type that makes up the liver perncyhma. Hepatocytes are usually binucleated and appear as sheets in the liver tissue." ; dc:date "2023-04-16T15:10:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal hepatocyte morphology" ; rdfs:subClassOf obo:HP_0030146 . obo:HP_0034714 obo:IAO_0000115 "Accumulation of dark, coarsely granular pigment localized in lysosomes of centrilobular hepatocytes." ; dc:date "2023-04-16T15:13:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hepatic melanin-like lysosomal pigmentation" ; rdfs:subClassOf obo:HP_0034713 . obo:HP_0034715 obo:IAO_0000115 "Activity of the enzyme uroporphyrinogen decarboxylase (UROD; EC 4.1.1.37) below the lower limit of normal." ; dc:date "2023-04-16T15:15:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Uroporphyrinogen decarboxylase low" ; rdfs:label "Reduced uroporphyrinogen decarboxylase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034716 obo:IAO_0000115 "Activity of the enzyme heme oxygenase below the lower limit of normal." ; dc:date "2023-04-16T15:20:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced heme oxygenase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034717 obo:IAO_0000115 "The presence of enlarged and swollen neurons that lack Nissl bodies (the rough endoplasmic reticulum-achromasia refers to neurons that lack Nissl bodies) in the cortex of the brain." ; dc:date "2023-04-16T15:22:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cerebral cortex Pick cells", "Cerebral cortex swollen achromatic neurons" ; a owl:Class ; rdfs:label "Swollen achromatic neurons in the cerebral cortex" ; rdfs:subClassOf obo:HP_0002538 . obo:HP_0034718 obo:IAO_0000115 "Presence of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in hepatocytes, which normally rarely contain vacuoles." ; dc:date "2023-04-16T15:29:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hepatocyte vacuolization" ; a owl:Class ; rdfs:label "Vacuolated hepatocytes" ; rdfs:subClassOf obo:HP_0034713 . obo:HP_0034719 obo:IAO_0000115 "An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination." ; dc:date "2023-04-16T15:46:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lack of oocyte pronucleus formation" ; rdfs:subClassOf obo:HP_0033338 . obo:HP_0034720 obo:IAO_0000115 "A type of skin tumor that initially presents as a reddish macule and subsequently becomes papular, enlarged, ulcerated and ultimately heals leaving pitted scars." ; dc:date "2023-04-16T15:54:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Individuals with pathogenic variants in TGFBR1 may present with multiple self-healing squamous epitheliomas. See Figure 1 of PMID:33256177." ; rdfs:label "Self-healing squamous epithelioma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0034721 obo:IAO_0000115 "Concentration of pristanic acid in the blood circulation above the upper limit of normal." ; dc:date "2023-04-21T20:13:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating pristanic acid concentration" ; rdfs:subClassOf obo:HP_0010964 . obo:HP_0034722 obo:IAO_0000115 "Rounded or oval structures that appeared brown on hematoxylin and eosin and red on the modified Gomori trichrome stain." ; dc:date "2023-04-21T20:15:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The sarcoplasm is the cytoplasm of a muscle cell." ; rdfs:label "Sarcoplasmic bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0034723 dc:date "2023-04-21T20:52:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Concentration of hydroxyproline in the cerebrospinal fluid (CSF) above the upper limit of normal." ; rdfs:label "Elevated CSF hydroxyproline concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034724 obo:IAO_0000115 "Concentration of cystine in the cerebrospinal fluid below the lower limit of normal. Cystine is sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond." ; dc:date "2023-04-21T21:24:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cystine low in CSF" ; a owl:Class ; rdfs:label "Reduced CSF cystine concentration" ; rdfs:subClassOf obo:HP_0500184 . obo:HP_0034725 obo:IAO_0000115 "Activity of the enzyme beta-mannosidase outside normal limits. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides." ; dc:date "2023-04-21T21:27:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal beta-mannosidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034726 obo:IAO_0000115 "Activity of the enzyme beta-mannosidase above the upper limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides." ; dc:date "2023-04-21T21:28:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Beta-mannosidase high in blood" ; a owl:Class ; rdfs:label "Elevated beta-mannosidase activity" ; rdfs:subClassOf obo:HP_0034725 . obo:HP_0034727 obo:IAO_0000115 "Activity of the enzyme alpha-L-fucosidase below the lower limit of normal." ; dc:date "2023-04-21T21:43:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced alpha-L-fucosidase activity" ; rdfs:subClassOf obo:HP_0034728 . obo:HP_0034728 obo:IAO_0000115 "Activity of the enzyme alpha-L-fucosidase outside the limits of normal." ; dc:date "2023-04-21T21:45:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal alpha-L-fucosidase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034729 obo:IAO_0000115 "Activity of the enzyme alpha-L-fucosidase above the upper limit of normal." ; dc:date "2023-04-21T21:46:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated alpha-L-fucosidase activity" ; rdfs:subClassOf obo:HP_0034728 . obo:HP_0034730 obo:IAO_0000115 "Increased concentration of S-adenosyl-L-homocysteine in the blood circulation." ; dc:date "2023-04-21T21:49:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated AdoHcy concentration" ; a owl:Class ; rdfs:label "Elevated circulating S-adenosyl-L-homocysteine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034731 obo:IAO_0000115 "Concentration S-adenosyl-L-methionine in the blood circulation above the upper limit of normal." ; dc:date "2023-04-21T21:50:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood AdoMet" ; a owl:Class ; rdfs:label "Elevated circulating S-adenosyl-L-methionine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034732 obo:IAO_0000115 "Malignant hyperthermia that is characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40 degrees C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure." ; dc:date "2023-05-07T17:32:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Exertional heat stroke", "Malignant hyperthermia due to exercise" ; a owl:Class ; rdfs:label "Exercise-triggered malignant hyperthermia" ; rdfs:subClassOf obo:HP_0002047 . obo:HP_0034733 obo:IAO_0000115 "Malignant hyperthermia that is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine." ; dc:date "2023-05-07T17:34:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Malignant hyperthermia with anaesthesia", "Malignant hyperthermia with anesthesia" ; a owl:Class ; rdfs:label "Anesthesic-triggered malignant hyperthermia" ; rdfs:subClassOf obo:HP_0002047 . obo:HP_0034734 obo:IAO_0000115 "Concentration of argininosuccinic acid in the cerebrospinal fluid (CSF) above the upper limit of normal." ; dc:date "2023-05-07T17:46:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Argininosuccinic acid high in CSF" ; a owl:Class ; rdfs:label "Elevated CSF argininosuccinic acid concentration" ; rdfs:subClassOf obo:HP_0500184 . obo:HP_0034735 obo:IAO_0000115 "Concentration of aspartylglucosamine in the cerebrospinal fluid (CSF) above the upper limit of normal." ; dc:date "2023-05-07T17:47:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Aspartylglucosamine high in CSF" ; a owl:Class ; rdfs:comment "Aspartylglucosamine is a derivative of aspartic acid." ; rdfs:label "Elevated CSF aspartylglucosamine concentration" ; rdfs:subClassOf obo:HP_0500184 . obo:HP_0034736 obo:IAO_0000115 "Concentration of alpha-oxoadipic acid in the blood above the upper limit of normal." ; dc:date "2023-05-07T17:53:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Alpha-oxoadipic acid high in blood" ; a owl:Class ; rdfs:label "Elevated circulating alpha-oxoadipic acid concentration" ; rdfs:subClassOf obo:HP_0010995 . obo:HP_0034737 obo:IAO_0000115 "A deviation from the normal range of a metabolite in red blood cells." ; dc:date "2023-05-07T17:56:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal erythrocyte metabolite concentration" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0034738 obo:IAO_0000115 "Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health." ; dc:date "2023-05-07T17:56:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced erythrocyte glutathione concentration" ; rdfs:subClassOf obo:HP_0034737 . obo:HP_0034739 obo:IAO_0000115 "Concentration of sarcosine in the cerebrospinal fluid (CSF) above the upper limit of normal." ; dc:date "2023-05-07T18:00:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Sarcosine high in CSF" ; a owl:Class ; rdfs:label "Elevated CSF sarcosine concentration" ; rdfs:subClassOf obo:HP_0500225 . obo:HP_0034740 obo:IAO_0000115 "Concentration of methionine in the cerebrospinal fluid below the lower limit of normal." ; dc:date "2023-05-07T18:01:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Methionine low in CSF" ; a owl:Class ; rdfs:label "Reduced CSF methionine concentration" ; rdfs:subClassOf obo:HP_0500209 . obo:HP_0034741 obo:IAO_0000115 "Concentration of homoarginine in the blood circulation above the upper limit of normal." ; dc:date "2023-05-07T18:04:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Homoarginine high in blood" ; a owl:Class ; rdfs:label "Elevated circulating homoarginine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034742 obo:IAO_0000115 "The concentration of formiminoglutamic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-05-07T18:10:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Formiminoglutamic acid high in urine" ; a owl:Class ; rdfs:label "Elevated urinary formiminoglutamic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034743 obo:IAO_0000115 "Concentration of proline in the cerebrospinal fluid (CSF) above the upper limit of normal." ; dc:date "2023-05-07T18:14:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated CSF proline concentration" ; rdfs:subClassOf obo:HP_0500184 . obo:HP_0034744 obo:IAO_0000115 "Level of S-sulfocysteine high in urine above the upper limit of normal." ; dc:date "2023-05-07T18:21:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "S-sulfocysteine high in urine" ; a owl:Class ; rdfs:label "Elevated urinary S-sulfocysteine level" ; rdfs:subClassOf obo:HP_0033098 . obo:HP_0034745 obo:IAO_0000115 "Concentration of S-sulfocysteine in the blood circulation above the upper limit of normal." ; dc:date "2023-05-07T18:24:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "S-sulfocysteine high in blood" ; a owl:Class ; rdfs:label "Elevated circulating S-sulfocysteine concentration" ; rdfs:subClassOf obo:HP_0033109 . obo:HP_0034746 obo:IAO_0000115 "Abnormal increase in the number of Sertoli cells in the testis." ; dc:date "2023-05-17T23:10:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sertoli cells are present in the seminiferous tubules of the testes, comprising one of the two types of cells in the germinal epithelium, the other being of spermatogonia lineage. Sertoli cells are one of the most important cells necessary for sperm production in males. They are often identifiable as big, tightly linked cells near the basolateral portion of the seminiferous tubule." ; rdfs:label "Sertoli cell hyperplasia" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0034747 obo:IAO_0000115 "The presence of an infectious agent in the cerebrospinal fluid (CSF)." ; dc:date "2023-05-18T11:58:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "CSF infectious agent" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0034748 obo:IAO_0000115 "Mycobacterium present in the cerebrospinal fluid (CSF). This feature can be ascertained by CSF microscopy." ; dc:date "2023-05-18T11:59:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "CSF mycobacteria" ; rdfs:subClassOf obo:HP_0034429 . obo:HP_0034749 obo:IAO_0000115 "Detection of a fungal organism (such as candida or coccidioides) in the blood stream." ; dc:date "2023-05-18T12:01:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fungi in blood" ; a owl:Class ; rdfs:label "Fungal bloodstream infection" ; rdfs:subClassOf obo:HP_0031863 . obo:HP_0034750 obo:IAO_0000115 "Enlarged lymph node located just above the clavicle (collarbone)." ; dc:date "2023-05-18T12:12:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Supraclavicular lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0034751 obo:IAO_0000115 "Enlarged lymph node located in the inguinal region (groin)." ; dc:date "2023-05-18T12:15:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Inguinal lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0034752 obo:IAO_0000115 "Enlarged lymph node located in the axillary region (armpit)." ; dc:date "2023-05-18T12:17:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Axillary lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716 . obo:HP_0034753 obo:IAO_0000115 "Murphy's sign is elicited in patients with acute cholecystitis by asking the patient to take in and hold a deep breath while palpating the subcostal region. In practice, Murphy's sign is performed by palpating the subcostal region during inspiration. If pain is elicited and the patient suddenly stops their inspiratory effort, a positive Murphy's sign has been elicited." ; dc:date "2023-05-18T12:25:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Murphy's sign", "Murphy's sign positive", "Sweeney's sign" ; a owl:Class ; rdfs:label "Positive Murphy sign" ; rdfs:subClassOf obo:HP_0011458 . obo:HP_0034754 obo:IAO_0000115 "Vomiting whereby the vomit has the color of bile, yellowish-green." ; dc:date "2023-05-18T12:27:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bilious emesis" ; rdfs:subClassOf obo:HP_0002013 . obo:HP_0034755 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with a nonsteroidal anti-inflammatory drug (NSAID)." ; dc:date "2023-05-20T14:16:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Ameliorated by nonsteroidal anti-inflammatory drug" ; a owl:Class ; rdfs:label "Ameliorated by NSAID" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034756 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to a medication or other substance." ; dc:date "2023-05-20T14:24:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fetal medication or drug exposure", "Maternal exposure history" ; a owl:Class ; rdfs:label "Fetal exposure history" ; rdfs:subClassOf obo:HP_0002686, obo:HP_4000110 . obo:HP_0034757 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to barbiturate medications such as phenobarbital. Barbiturates are used medically as anxiolytics, hypnotics, and anticonvulsants." ; dc:date "2023-05-20T14:25:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal barbiturate use" ; a owl:Class ; rdfs:label "Fetal barbiturate exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034758 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to narcotic medications such as morphine or codeine. Narcotics are used medically to treat moderate or severe pain." ; dc:date "2023-05-20T14:27:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal narcotic exposure" ; a owl:Class ; rdfs:label "Fetal narcotic exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034759 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by administration of ethosuximide. Ethosuximide is most often used to treat absence seizures." ; dc:date "2023-05-20T14:30:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by ethosuximide" ; rdfs:subClassOf obo:HP_0025254 . obo:HP_0034760 obo:IAO_0000115 "Lower than normal amount of extracellular matrix protein 1 (ECM1) in the epidermis." ; dc:date "2023-05-20T14:39:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced epidermal ECM1 protein expression" ; a owl:Class ; rdfs:label "Reduced epidermal extracellular matrix protein 1 protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0034761 obo:IAO_0000115 "Neurofibroma categorized according to the anatomical site of origin." ; dc:date "2023-05-20T14:57:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neurofibroma by anatomical location" ; rdfs:subClassOf obo:HP_0001067 . obo:HP_0034762 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the tongue." ; dc:date "2023-05-20T14:58:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Tongue neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0034763 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the heart." ; dc:date "2023-05-20T14:59:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiac neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0034764 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the stomach." ; dc:date "2023-05-20T15:00:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gastric neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0034765 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the kidney." ; dc:date "2023-05-20T15:01:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Renal neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0034766 obo:IAO_0000115 "Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in muscle fibers." ; dc:date "2023-05-20T15:11:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: polyglucosan accumulation" ; a owl:Class ; rdfs:label "Muscle fiber polyglucosan inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0034767 obo:IAO_0000115 """Abnormal structure of the rete ridges (also known as rete pegs), which are downward projections of epithelium surrounding the connective tissue papillae in between the dermal papillae.""" ; dc:date "2023-05-20T15:16:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal rete ridge morphology" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034768 obo:IAO_0000115 "Increased length of the rete rdiges of the epidermis." ; dc:date "2023-05-20T15:18:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elongation of rete ridges", "Rete ridges elongated" ; a owl:Class ; rdfs:label "Rete ridge elongation" ; rdfs:subClassOf obo:HP_0034767 . obo:HP_0034769 obo:IAO_0000115 "Accumulation of monoclonal CD1a-positive Langerhans cells in the bronchioles and alveolar interstitium that can cause damage to the lungs." ; dc:date "2023-05-20T15:32:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pulmonary Langerhans cell histiocytosis" ; rdfs:subClassOf obo:HP_0006530 . obo:HP_0034770 obo:IAO_0000115 "Flattening of a curve in the spine in the lumbar (lower back) region." ; dc:date "2023-06-04T11:01:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced lumbar lordosis" ; a owl:Class ; rdfs:label "Lumbar hypolordosis" ; rdfs:subClassOf obo:HP_0010674 . obo:HP_0034771 obo:IAO_0000115 "Battle sign is bruising over the mastoid process that is typically the result of head trauma. It is retroauricular or mastoid ecchymosis that is typically the result of head trauma. Battle sign typically requires significant head trauma and may indicate significant internal injury to the brain and not just the posterior cranial vault or mastoid." ; dc:date "2023-06-04T11:17:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Battle sign bruise", "Battle's sign" ; a owl:Class ; rdfs:label "Battle sign" ; rdfs:subClassOf obo:HP_0031364 . obo:HP_0034772 obo:IAO_0000115 "Reduced anterioposterior dimension of the skull base." ; dc:date "2023-06-04T11:21:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased cranial base length", "Short skull base" ; a owl:Class ; rdfs:label "Decreased skull base length" ; rdfs:subClassOf obo:HP_0002693 . obo:HP_0034773 obo:IAO_0000115 "A visual disturbance in which objects in the visual field appear to oscillate (jump, jiggle, vibrate)." ; dc:date "2023-06-04T11:24:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Oscillopsia most often results from abnormal eye movements or from impaired vestibulo-ocular reflex." ; rdfs:label "Oscillopsia" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0034774 obo:IAO_0000115 "The frequency with which the eye is blinked is below the lower limit of normal." ; dc:date "2023-06-04T11:27:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Blinking reduced" ; a owl:Class ; rdfs:comment "A reduced blink rate may be observed in Parkinson's disease." ; rdfs:label "Decreased blink rate" ; rdfs:subClassOf obo:HP_0034775 . obo:HP_0034775 obo:IAO_0000115 "A deviation from the normal frequency of blinking the eye." ; dc:date "2023-06-04T11:27:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal blink rate" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0034776 obo:IAO_0000115 "The frequecy with which the eye is blinked is above the upper limit of normal." ; dc:date "2023-06-04T11:28:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An increased blink rate in can be observed in schizophrenia, tardive dyskinesia, Tourette's syndrome and Meige's disease." ; rdfs:label "Elevated blink rate" ; rdfs:subClassOf obo:HP_0034775 . obo:HP_0034777 obo:IAO_0000115 "Sputum contains pus." ; dc:date "2023-06-04T11:31:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Purulent sputum" ; rdfs:subClassOf obo:HP_0032016 . obo:HP_0034778 obo:IAO_0000115 "The mother of a fetus or index patient has a history of hyperthyroidism during the corresponding pregnancy." ; dc:date "2023-06-04T11:35:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Maternal hyperthyroidism" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0034779 obo:IAO_0000115 "Applies to an abnormality that affects the perineum (the region of skin between the genitals and the anus)." ; dc:date "2023-06-04T11:37:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Perineal distribution to finding", "Perineal location" ; a owl:Class ; rdfs:label "Perineal" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0034780 obo:IAO_0000115 "History of exposure to gadolinium, a contrast medium often used for magnetic resonance imaging." ; dc:date "2023-06-04T11:40:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gadolinium exposure" ; rdfs:subClassOf obo:HP_4000110 . obo:HP_0034781 obo:IAO_0000115 "Excretion of pus (purulent discharge) from the opening of the parotid duct." ; dc:date "2023-06-04T11:43:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Purulent Stensen duct drainage" ; a owl:Class ; rdfs:comment "See Figure 2 of PMID:34952006." ; rdfs:label "Purulent parotid gland drainage" ; rdfs:subClassOf obo:HP_0000197 . obo:HP_0034782 obo:IAO_0000115 "Obstipation is the inability to pass either stool or flatus (gas)." ; dc:date "2023-06-12T12:48:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lack of flatulence", "No gas passage" ; oboInOwl:hasRelatedSynonym "Tympanic distended abdomen" ; a owl:Class ; rdfs:comment "Obstipation can be a sign of an acute obstruction of the GI tract, either of the small or large bowel." ; rdfs:label "Obstipation" ; rdfs:subClassOf obo:HP_0002019 . obo:HP_0034783 obo:IAO_0000115 "Vomiting following a coughing spell." ; dc:date "2023-06-12T12:55:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Individuals with gastroesophageal reflux disease (GERD) will frequently vomit when coughing for a non-GI reason. Vomiting occurs during these coughing spells because the intrabdominal pressure is high from the coughing and the propensity to reflux results in stomach contents emerging as vomit. This is a historical question that allows a parent to impart information suggesting GERD at an age when it is difficult to obtain a reliable GERD history from the child." ; rdfs:label "Posttussive emesis" ; rdfs:subClassOf obo:HP_0002013 . obo:HP_0034784 obo:IAO_0000115 "Vasculitis categorized according to the anatomical site where the finding is localized." ; dc:date "2023-06-12T12:58:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vasculitis by anatomical site" ; rdfs:subClassOf obo:HP_0002633 . obo:HP_0034785 obo:IAO_0000115 "Vasculitis categorized according to type of histological abnormality." ; dc:date "2023-06-12T12:59:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vasculitis by histology" ; rdfs:subClassOf obo:HP_0002633 . obo:HP_0034786 obo:IAO_0000115 "A type of vasculitis characterized by the presence of debris of neutrophils within the blood vessel walls." ; dc:date "2023-06-12T13:00:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Leukocytoclastic vasculitis" ; rdfs:subClassOf obo:HP_0034785 . obo:HP_0034787 dc:date "2023-06-12T13:14:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The finding can be observed by strong brown cytoplasmic peroxidase staining of enterozytes in a biopsy specimen. See Figure 2 of PMID: 2426307." ; rdfs:label "Accumulation of lipid droplets in small-bowel enterocytes" ; rdfs:subClassOf obo:HP_0025129 . obo:HP_0034788 obo:IAO_0000115 "A pericardial friction rub is a grating, to-and-fro sound that occurs in phase with the heart sounds." ; dc:date "2023-06-12T13:19:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cardiac rub" ; a owl:Class ; rdfs:comment "Pericardial friction rubs can be differentiated from pleural friction rubs because they occur independently of breathing. A pericardial rub is highly specific for acute pericarditis. It is generally heard over the left sternal border, it is often louder at inspiration but sometimes can be better heard on forced expiration while the patient bends forward. In most cases, the rub is triphasic (audible in atrial, ventricular systole, and ventricular diastole phases) and is of high frequency." ; rdfs:label "Pericardial friction rub" ; rdfs:subClassOf obo:HP_0031657 . obo:HP_0034789 dc:date "2023-06-12T13:30:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Skeletal muscle vasculitis" ; a owl:Class ; rdfs:label "Muscular vasculitis" ; rdfs:subClassOf obo:HP_0034784 . obo:HP_0034790 obo:IAO_0000115 "Any deviation from the normal amount of staining of succinate dehydrogenase in skeletal muscle tissue." ; dc:date "2023-06-12T13:36:22Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Succinate dehydrogenase (SDH) is a mitochondrial enzyme complex located in the inner mitochondrial membrane that has dual roles in the oxidation of succinate to fumarate in the Krebs cycle and in electron transport during oxidative phosphorylation." ; rdfs:label "Abnormal muscle succinate dehydrogenase staining" ; rdfs:subClassOf obo:HP_0034510 . obo:HP_0034791 dc:date "2023-06-12T13:39:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Staining of succinate dehydrogenase in skeletal muscle tissue above the upper limit of normal." ; rdfs:label "Increased muscle succinate dehydrogenase staining" ; rdfs:subClassOf obo:HP_0034790 . obo:HP_0034792 dc:date "2023-06-12T13:40:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Staining of succinate dehydrogenase in skeletal muscle tissue below the lower limit of normal." ; rdfs:label "Decreased muscle succinate dehydrogenase staining" ; rdfs:subClassOf obo:HP_0034790 . obo:HP_0034793 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the small intestine." ; dc:date "2023-06-12T13:42:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small intestinal hamartoma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100833 . obo:HP_0034794 obo:IAO_0000115 "Pyriform spermatozoa consist of a normally shaped acrosomal structure which can be normal in size or enlarged, while the post-acrosomal region shows severe elongation and an acute narrowing to the posterior end, ending in about the same thickness as the connecting mid-piece." ; dc:date "2023-06-18T23:46:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pyriform head" ; a owl:Class ; rdfs:label "Pyriform sperm head" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0034795 obo:IAO_0000115 "Excess residual cytoplasm is associated with abnormal spermatozoa produced from a defective spermiation process. This abnormal excess cytoplasm should not be confused with more physiological cytoplasmic residues that can be observed in direct microscopy of the ejaculate but not in dried, fixed and stained morphology smears." ; dc:date "2023-06-18T23:49:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Excess residual spermatozoal cytoplasm" ; rdfs:subClassOf obo:HP_0012864 . obo:HP_0034796 obo:IAO_0000115 "Subsarcolemmal, eosinophilic glass-like regions within the cytoplasm of cardiomyocytes." ; dc:date "2023-06-18T23:59:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiomyocyte hyaline bodies" ; rdfs:subClassOf obo:HP_0031334 . obo:HP_0034797 obo:IAO_0000115 "Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the liver." ; dc:date "2023-06-19T00:22:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hepatic hemophagocytosis" ; rdfs:subClassOf obo:HP_0012156 . obo:HP_0034798 obo:IAO_0000115 "Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the cerebrospinal fluid (CSF)." ; dc:date "2023-06-19T00:23:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hemophagocytosis in CSF" ; a owl:Class ; rdfs:label "CSF hemophagocytosis" ; rdfs:subClassOf obo:HP_0012156 . obo:HP_0034799 obo:IAO_0000115 "Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen." ; dc:date "2023-06-19T00:24:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Spleen hemophagocytosis" ; a owl:Class ; rdfs:label "Splenic hemophagocytosis" ; rdfs:subClassOf obo:HP_0012156 . obo:HP_0034800 obo:IAO_0000115 "The presence of multiple granulomas in the urinary bladder as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes." ; dc:date "2023-06-19T00:26:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Urinary bladder granulomas" ; a owl:Class ; rdfs:label "Urinary bladder granulomatosis" ; rdfs:subClassOf obo:HP_0002955 . obo:HP_0034801 obo:IAO_0000115 "Death of keratinocytes in the epidermis layer of the skin, which generally manifests as extensive exfoliation (separation of the epidermis from the underlying dermis)." ; dc:date "2023-06-19T00:29:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Epidermal necrosis" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034802 obo:IAO_0000115 "Applied to a sign or symptom that is aggravated by (or made more painful by) bending of a limb or joint." ; dc:date "2023-07-01T10:08:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by flexion" ; rdfs:subClassOf obo:HP_0025285 . obo:HP_0034803 obo:IAO_0000115 "The presence of blood in tears." ; dc:date "2023-07-01T10:11:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bloody epiphora", "Bloody tears", "Red tears" ; a owl:Class ; rdfs:label "Hemolacria" ; rdfs:subClassOf obo:HP_0000632 . obo:HP_0034804 obo:IAO_0000115 "A perception that an object is in contact with the eye." ; dc:date "2023-07-01T11:00:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Corneal foreign body sensation" ; rdfs:subClassOf obo:HP_0012373 . obo:HP_0034805 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the buttock (round fleshy area at the lower rear area of a human trunk)." ; dc:date "2023-07-01T11:04:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Buttock pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0034806 obo:IAO_0000115 "A perception that an object located in the vagina." ; dc:date "2023-07-01T11:06:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vaginal foreign body sensation" ; rdfs:subClassOf obo:HP_0034268 . obo:HP_0034807 obo:IAO_0000115 """Attacks of breathlessness that occur at night and may awaken the sleeping patient.""" ; dc:date "2023-07-01T11:11:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Paroxysmal nocturnal dyspnoea" ; a owl:Class ; rdfs:label "Paroxysmal nocturnal dyspnea" ; rdfs:subClassOf obo:HP_0002094 . obo:HP_0034808 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eyelid." ; dc:date "2023-07-01T11:16:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Eyelid pain" ; rdfs:subClassOf obo:HP_0012531, obo:HP_0031879 . obo:HP_0034809 obo:IAO_0000115 "Abnormality of a sperm function including protection of paternal DNA, traversing the female reproductive tract, oocyte localisation, penetration of the zona pellucida, oocyte activation and centriole deposition." ; dc:date "2023-07-01T11:30:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal sperm physiology" ; rdfs:subClassOf obo:HP_0000025 . obo:HP_0034810 obo:IAO_0000115 "Reduction in size of the acrosome below the lower limit of normal. The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus. According to the World Health Organization criteria, the acrosome must be clearly visible, comprising approximately 40-70 percent of the sperm head." ; dc:date "2023-07-01T11:43:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Small acrosomal area" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0034811 obo:IAO_0000115 "The proportion of sperm cells whose flagella is sharply curved or has a sharp angle is above normal limits." ; dc:date "2023-07-01T11:53:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bent sperm flagella" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0034812 obo:IAO_0000115 "Spermiation failure is indicated by apparently normal spermiogenesis, but the presence of retained Sd2 spermatids in stages III-V of human spermatogenesis, whereas maturation arrest is indicated by a lack of late Sd1 and Sd2 spermatids in the epithelium." ; dc:date "2023-07-01T12:16:07Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; a owl:Class ; rdfs:comment "It is important to note that multiple spermatogenic abnormalities often occur simultaneously in infertile men, and the helical nature of human spermatogenesis can make it difficult to readily discriminate multiple abnormalities of spermatid development and release." ; rdfs:label "Spermiation failure" ; rdfs:subClassOf obo:HP_0011961 . obo:HP_0034813 obo:IAO_0000115 "A morphological abnormality visible upon biopsy of the germinal epithelium of the testis in which the cellularity of the germinal epithelium is reduced in general, so that all stages of germ cells (spermatogonia, spermatocytes, and spermatids) are present but reduced in number. This term applies to biopsies with some tubules showing diminished amounts of qualitatively complete spermatogenesis in combination with a vast majority of tubules that lack germ cells." ; dc:date "2023-07-01T12:26:25Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; a owl:Class ; rdfs:label "Hypospermatogenesis" ; rdfs:subClassOf obo:HP_0008669 . obo:HP_0034814 obo:IAO_0000115 "Formation of a sheet of tissue by coagulum of exudate over the conjunctiva of the eye that if removed leaves behind a denuded bleeding surface." ; dc:date "2023-07-01T13:01:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Conjunctival membrane" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0034815 obo:IAO_0000115 "A type of oligozoospermia characterized by a total number of more than zero but less than 2 million sperm in the ejaculate or a concentration of more than zero but less than one million sperm per milliliter." ; dc:date "2023-07-01T13:05:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extreme oligozoospermia" ; rdfs:subClassOf obo:HP_0000798 . obo:HP_0034816 obo:IAO_0000115 "A type of oligozoospermia characterized by a total number of more than 30 but less than 39 million sperm in the ejaculate or a concentration of more than 10 but less than 15 million sperm per milliliter." ; dc:date "2023-07-01T13:06:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Mild oligozoospermia" ; rdfs:subClassOf obo:HP_0000798 . obo:HP_0034817 obo:IAO_0000115 "A type of oligozoospermia characterized by a total number of more than 10 but less than 29 million sperm in the ejaculate or a concentration of more than 5 but less than 10 million sperm per milliliter." ; dc:date "2023-07-01T13:07:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Moderate oligozoospermia" ; rdfs:subClassOf obo:HP_0000798 . obo:HP_0034818 obo:IAO_0000115 "A type of oligozoospermia characterized by a total number of more than 2 but less than 10 million sperm in the ejaculate or a concentration of more than 1 but less than 5 million sperm per milliliter." ; dc:date "2023-07-01T13:08:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Severe oligozoospermia" ; rdfs:subClassOf obo:HP_0000798 . obo:HP_0034819 obo:IAO_0000115 "The presence of a nodule (small rounded lump of tissue) in the iris." ; dc:date "2023-07-01T13:30:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Iris nodule" ; rdfs:subClassOf obo:HP_0000525 . obo:HP_0034820 obo:IAO_0000115 "A type of iris nodule consisting of inflammatory cell precipitates which lie at the pupillary margin." ; dc:date "2023-07-01T13:30:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Koeppe iris nodules", "Koeppe's nodules" ; a owl:Class ; rdfs:comment "Koeppe nodules can be observed in non-granulomaous and granulomatous uveitis." ; rdfs:label "Koeppe nodules" ; rdfs:subClassOf obo:HP_0034819 . obo:HP_0034821 obo:IAO_0000115 "A type of iris nodule consisting of inflammatory cell precipitates which lie on the iris surface." ; dc:date "2023-07-01T13:49:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bussace nodules are considered pathognomonic for granulomatous uveitis." ; rdfs:label "Bussaca nodules" ; rdfs:subClassOf obo:HP_0034819 . obo:HP_0034822 dc:date "2023-07-01T16:37:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal CSF ion concentration" ; rdfs:subClassOf obo:HP_0002921 . obo:HP_0034823 obo:IAO_0000115 "Concentration of copper in the cerebrospinal fluid (CSF) below the lower limit of normal." ; dc:date "2023-07-01T16:38:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Copper low in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF copper concentration" ; rdfs:subClassOf obo:HP_0034822 . obo:HP_0034824 obo:IAO_0000115 "Diffuse lymphoid hyperplasia (DLH) describes the pathological entity that lies between follicular bronchiolitis and lymphocytic interstitial pneumonia (LIP). It is pathologically characterized by a diffuse peribronchiolar proliferation of hyperplastic lymphoid follicles (BALT), extended along the lymphatics to involve the interlobular septa and pleura. Unlike LIP, DHL does not show uniform involvement of the alveolar septa." ; dc:date "2023-07-01T16:44:28Z"^^xsd:dateTime ; dcterms:contributor , ; dcterms:creator ; a owl:Class ; rdfs:label "Diffuse pulmonary lymphoid hyperplasia" ; rdfs:subClassOf obo:HP_0033582 . obo:HP_0034825 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by treatment with a steroid medication such as prednisone." ; dc:date "2023-07-01T17:08:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ameliorated by steroid medication" ; rdfs:subClassOf obo:HP_0034536 . obo:HP_0034826 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by administration of a medication." ; dc:date "2023-07-01T17:10:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by medication exposure" ; rdfs:subClassOf obo:HP_0025204 . obo:HP_0034827 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by administration of levothyroxin (thyroid hormone)." ; dc:date "2023-07-01T17:10:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Triggered by levothyroxin exposure" ; rdfs:subClassOf obo:HP_0034826 . obo:HP_0034828 obo:IAO_0000115 "A decreased amount of laminin alpha-2 chain in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue." ; dc:date "2023-07-01T18:08:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced muscle laminin alpha-2 chain staining" ; rdfs:subClassOf obo:HP_0034510 . obo:HP_0034829 obo:IAO_0000115 "Abnormal thickening of of the outer layer (cortex) of the adrenal gland due to fibrosis." ; dc:date "2023-07-01T18:18:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 4 of PMID:4014441." ; rdfs:label "Adrenal cortical sclerosis" ; rdfs:subClassOf obo:HP_0011732 . obo:HP_0034830 obo:IAO_0000115 "Concentration or activity of fructose 1,6-bisphosphate aldolase in liver tissue below the lower limit of normal." ; dc:date "2023-07-01T18:53:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic fructose-1,6-phosphate aldolase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034831 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the pancreas." ; dc:date "2023-07-01T19:06:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pancreatic hamartoma" ; rdfs:subClassOf obo:HP_0010566 . obo:HP_0034832 obo:IAO_0000115 "A benign liver neoplasm composed of fat, vascular, and smooth muscle elements." ; dc:date "2023-07-01T19:08:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hepatic angiomyolipoma" ; a owl:Class ; rdfs:label "Liver angiomyolipoma" ; rdfs:subClassOf obo:HP_0034514 . obo:HP_0034833 obo:IAO_0000115 "A lipoma that is located within a the heart." ; dc:date "2023-07-01T19:09:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiac lipoma" ; rdfs:subClassOf obo:HP_0012032 . obo:HP_0034834 obo:IAO_0000115 "Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in peripheral nerve fibers." ; dc:date "2023-07-01T19:11:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peripheral nerve polyglucosan inclusion bodies" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0034835 obo:IAO_0000115 "Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in myocardial tissue." ; dc:date "2023-07-01T19:32:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cardiac polyglucosan accumulation" ; rdfs:subClassOf obo:HP_0001637 . obo:HP_0034836 obo:IAO_0000115 "A benign cystic neoplasm of the kidney." ; dc:date "2023-07-01T19:34:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bbenign multilocular cystic nephroma", "Multicystic nephroma", "Multilocular cystic renal tumor", "Polycystic nephroblastoma" ; a owl:Class ; rdfs:comment "The pathogenesis of cystic nephroma is controversial and there is no generally accepted classification." ; rdfs:label "Cystic nephroma" ; rdfs:subClassOf obo:HP_0009726 . obo:HP_0034837 obo:IAO_0000115 "Elastic fibers not demonstrable in skin biopsy." ; dc:date "2023-07-01T19:38:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absent dermal elastic fibers" ; rdfs:subClassOf obo:HP_0025082 . obo:HP_0034838 obo:IAO_0000115 "Splitting of the skin (cell-cell adhesion of keratinocytes) localized to the interface betweem the stratum corneum and stratum granulosum layers of the epidermis." ; dc:date "2023-07-01T19:42:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cleavage at junction of stratum corneum and stratum granulosum" ; rdfs:subClassOf obo:HP_0033802 . obo:HP_0034839 obo:IAO_0000115 "An abnormal bone marrow finding characterized by many poorly circumscribed and occasionally confluent lymphoid nodules. The nodules contain small and uniform lymphocytes with rounded nuclei, clumped chromatin, and without prominent nucleoli." ; dc:date "2023-07-01T19:48:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The appearance of lymphoid hyperplasia may resemble that of malignant lymphoma, well-differentiated lymphocytic type." ; rdfs:label "Lymphoid hyperplasia" ; rdfs:subClassOf obo:HP_0005561 . obo:HP_0034840 obo:IAO_0000115 "Lack of lamellar bodies (LBs) inthe epidermis. LBs are specialized organelles that contain pro-barrier lipids imparting a fully lamellar internal structure, but also other cargoes such as enzymes (lipid metabolizing and proteolytic), enzyme inhibitors, and antimicrobial peptides." ; dc:date "2023-07-01T21:40:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Harlequin ichthyosis is characterized by absence of epidermial lamellar bodies." ; rdfs:label "Absence of epidermal lamellar bodies" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0034841 obo:IAO_0000115 "The presence of multiple granulomas in the gastrointestinal tract (Pylorus, esophagus, jejunum, ileum, cecum, rectum, perirectal area, esophagus) as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes." ; dc:date "2023-07-01T21:47:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gastrointestinal granulomatosis" ; rdfs:subClassOf obo:HP_0002955 . obo:HP_0034842 obo:IAO_0000115 "Increased size of sperm vacuoles, which are surface concavities typically located at the the tip or middle area of sperm heads. According to the WHO Laboratory Manual for the Examination and Processing of Human Semen, sperm head vacuoles are considered abnormal when exceeding 20% of the cross-sectional area of the head. Vacuoles are found in almost all samples with normal sperm morphology; this term applies if the proportion of sperm with abnormally large vacuoles is above the upper limit of normal." ; dc:date "2023-07-03T10:22:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Enlarged sperm head vacuole" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0034843 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the ureter." ; dc:date "2023-07-03T10:45:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ureteral hamartoma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100516 . obo:HP_0034844 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to methimazole." ; dc:date "2023-07-03T10:53:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal methimazole exposure", "Methimazole exposure during gestation" ; a owl:Class ; rdfs:label "Fetal methimazole exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034845 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to procarbazine." ; dc:date "2023-07-03T10:55:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal procarbazine exposure", "Procarbazine exposure during gestation" ; a owl:Class ; rdfs:label "Fetal procarbazine exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034846 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to fluorouracil." ; dc:date "2023-07-03T10:57:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fluorouracil exposure during gestation", "Maternal fluorouracil exposure" ; a owl:Class ; rdfs:label "Fetal fluorouracil exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034847 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to cytarabine." ; dc:date "2023-07-03T10:59:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cytarabine exposure during gestation", "Maternal cytarabine exposure" ; a owl:Class ; rdfs:label "Fetal cytarabine exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034848 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to tetracycline." ; dc:date "2023-07-03T11:00:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal tetracycline exposure", "Tetracycline exposure during gestation" ; a owl:Class ; rdfs:label "Fetal tetracycline exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034849 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to quinine." ; dc:date "2023-07-03T11:01:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal quinine exposure", "Quinine exposure during gestation" ; a owl:Class ; rdfs:label "Fetal quinine exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034850 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to cyclophosphamide." ; dc:date "2023-07-03T11:04:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cyclophosphamide exposure during gestation", "Maternal cyclophosphamide exposure" ; a owl:Class ; rdfs:label "Fetal cyclophosphamide exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034851 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to metronidazole." ; dc:date "2023-07-03T11:06:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal metronidazole exposure", "Metronidazole exposure during gestation" ; a owl:Class ; rdfs:label "Fetal metronidazole exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034852 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to phenobarbital." ; dc:date "2023-07-03T11:07:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal phenobarbital exposure", "Phenobarbital exposure during gestation" ; a owl:Class ; rdfs:label "Fetal phenobarbital exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034853 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to phenytoin." ; dc:date "2023-07-03T11:08:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Maternal phenytoin exposure", "Phenytoin exposure during gestation" ; a owl:Class ; rdfs:label "Fetal phenytoin exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034854 obo:IAO_0000115 "Applies to an abnormality whose distribution and appearance are located at or near the umbilicus (belly button)." ; dc:date "2023-07-03T11:15:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Periumbilical" ; rdfs:subClassOf obo:HP_0012836 . obo:HP_0034855 obo:IAO_0000115 "A history of obesity, which can be defined as a body mass index of 30 or greater, in the mother of a fetus or index patient." ; dc:date "2023-07-03T11:51:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Maternal obesity during pregnancy" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0034856 obo:IAO_0000115 "A history of amniocentesis having been performed in the mother of a fetus or index patient." ; dc:date "2023-07-03T11:54:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Complications of amniocentesis are rare but include fetal loss, amniotic fluid leak, fetal lung hypoplasia, and fetal injuries like bleeding from the cord, ocular injuries, and postural deformities like talipes equinovarus (clubfoot)." ; rdfs:label "Maternal amniocentesis" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0034857 obo:IAO_0000115 "Description of conditions in which age of onset is highly variable even in family members who share the same disease-associated variant or variants." ; dc:date "2023-07-06T17:23:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Typified by highly variable age of onset" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0034858 obo:IAO_0000115 "Concentration or activity of an enzyme as measured in leukocytes is above or below the limits of normal in the blood circulation." ; dc:date "2023-07-08T15:40:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal leukocyte enzyme concentration or activity" ; rdfs:subClassOf obo:HP_0034684 . obo:HP_0034859 obo:IAO_0000115 "Concentration or activity of an beta-glucuronidase as measured in leukocytes is below the limits of normal in the blood circulation." ; dc:date "2023-07-08T15:41:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Beta-glucuronidase low in leukocytes" ; a owl:Class ; rdfs:label "Reduced leukocyte beta-glucuronidase activity" ; rdfs:subClassOf obo:HP_0034858 . obo:HP_0034860 obo:IAO_0000115 "Concentration or activity of an alpha-L-fucosidase as measured in leukocytes is below the limits of normal in the blood circulation." ; dc:date "2023-07-08T16:06:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature is characteristic of fucosidosis." ; rdfs:label "Reduced leukocyte alpha-L-fucosidase activity" ; rdfs:subClassOf obo:HP_0034858 . obo:HP_0034861 obo:IAO_0000115 "Concentration or activity of an arylsulfatase B as measured in leukocytes is below the limits of normal in the blood circulation." ; dc:date "2023-07-08T16:26:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This finding is characteristic of mucopolysaccharidosis type VI (MPS6). Reduced arylsulfatase activity can also be measured in cultured fibroblasts." ; rdfs:label "Reduced leukocyte arylsulfatase B activity" ; rdfs:subClassOf obo:HP_0034858 . obo:HP_0034862 obo:IAO_0000115 "Concentration or activity of an arylsulfatase C as measured in leukocytes is below the limits of normal in the blood circulation." ; dc:date "2023-07-08T16:31:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced leukocyte arylsulfatase C activity" ; a owl:Class ; rdfs:comment "Reduced activity of steroid sulfatase, also called arylsulfatase C, is characteristic of X-linked ichthyosis." ; rdfs:label "Reduced leukocyte steroid sulfatase activity" ; rdfs:subClassOf obo:HP_0034858 . obo:HP_0034863 obo:IAO_0000115 "Concentration or activity of an arylsulfatase A as measured in leukocytes is below the limits of normal in the blood circulation." ; dc:date "2023-07-08T16:36:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This finding is characteristic of metachromatic leukodystrophy. Reduced activity can also be measured in cultured fibroblasts." ; rdfs:label "Reduced leukocyte arylsulfatase A activity" ; rdfs:subClassOf obo:HP_0034858 . obo:HP_0034864 obo:IAO_0000115 "Activity of the enzyme alpha-galactosidase outsidebelow the lower limit of normal." ; dc:date "2023-07-08T16:52:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fabry disease is a lysosomal storage disorder caused by pathogenic variants in the X-linked GLA (alpha Galactosidase A) gene (Xq22.1)." ; rdfs:label "Decreased alpha-galactosidase A activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034865 obo:IAO_0000115 "Demonstration of parasite in stool specimen, e.g., Parasites present on wet mount of stool.e" ; dc:date "2023-07-08T17:07:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Positive stool parasite test" ; a owl:Class ; rdfs:label "Positive fecal parasite test" ; rdfs:subClassOf obo:HP_0034866 . obo:HP_0034866 obo:IAO_0000115 "Any kind of test for an infectious agent in stool positive." ; dc:date "2023-07-08T17:10:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive stool infectious agent test" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0034867 obo:IAO_0000115 "Test for giardia antigen in stool such as immune assay or DFA positive." ; dc:date "2023-07-08T17:11:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive stool giardia antigen" ; rdfs:subClassOf obo:HP_0034866 . obo:HP_0034868 obo:IAO_0000115 "Demonstration of antibody directed against Entamoeba histolytica in stool." ; dc:date "2023-07-08T17:12:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Entamoeba histolytica antibody positive in stool" ; rdfs:subClassOf obo:HP_0034866 . obo:HP_0034869 obo:IAO_0000115 "Concentration of porphyrin in erythrocytes below the lower limit of normal." ; dc:date "2023-07-08T17:18:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced erythrocyte free porphyrin concentration" ; rdfs:subClassOf obo:HP_0010472 . obo:HP_0034870 obo:IAO_0000115 "The concentration of urocanic acid in the blood circulation is below the lower limit of normal." ; dc:date "2023-07-08T17:21:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Urocanic acid low in blood" ; a owl:Class ; rdfs:label "Reduced circulating urocanic acid concentration" ; rdfs:subClassOf obo:HP_0010996 . obo:HP_0034871 obo:IAO_0000115 "The concentration of epinephrine in the urine, normalized for urine concentration, is below the lower limit of normal." ; dc:date "2023-07-08T17:31:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary epinephrine level" ; rdfs:subClassOf obo:HP_0045012 . obo:HP_0034872 obo:IAO_0000115 "Concentration of epinephrine in the cerebrospinal fluid below the lower limit of normal." ; dc:date "2023-07-08T17:37:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased CSF epinephrine concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034873 obo:IAO_0000115 "Concentration of epinephrin in the blood circulation below the lower limit of normal." ; dc:date "2023-07-08T17:39:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating epinephrine concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034874 obo:IAO_0000115 "Concentration of norepinephrin in the blood circulation below the lower limit of normal." ; dc:date "2023-07-08T17:40:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating norepinephrine concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034875 obo:IAO_0000115 "The concentration of norepinephrine in the urine, normalized for urine concentration, is below the lower limit of normal." ; dc:date "2023-07-08T17:42:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary norepinephrine level" ; rdfs:subClassOf obo:HP_0045012 . obo:HP_0034876 obo:IAO_0000115 "The concentration of metanephrine in the urine, normalized for urine concentration, is below the lower limit of normal." ; dc:date "2023-07-08T17:43:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary metaepinephrine level" ; rdfs:subClassOf obo:HP_0045012 . obo:HP_0034877 obo:IAO_0000115 "Concentration of metanephrine in the cerebrospinal fluid below the lower limit of normal." ; dc:date "2023-07-08T17:44:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased CSF metanephrine concentration" ; rdfs:subClassOf obo:HP_0025454 . obo:HP_0034878 obo:IAO_0000115 "Concentration of metanephrin in the blood circulation below the lower limit of normal." ; dc:date "2023-07-08T17:44:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating metanephrine concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034879 obo:IAO_0000115 "A swelling or enlargment localized to the ovary. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-08T17:47:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An ovarian mass may be initially found upon ultrasound, CT, or MRI investigation." ; rdfs:label "Ovarian mass" ; rdfs:subClassOf obo:HP_0031065 . obo:HP_0034880 obo:IAO_0000115 "A swelling or enlargment localized to the adrenal gland. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-08T17:53:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Adrenal mass" ; rdfs:subClassOf obo:HP_0011732 . obo:HP_0034881 obo:IAO_0000115 "A swelling or enlargment localized to the uterus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-08T17:54:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine mass" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0034882 obo:IAO_0000115 "Calcium deposits in the prostate gland." ; dc:date "2023-07-08T18:38:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Prostatic calcul" ; a owl:Class ; rdfs:comment "Most cases of prostatic calculi are not accompanied by symptoms. Therefore, most cases are found incidentally during the diagnosis of BPH using transrectal ultrasonography." ; rdfs:label "Prostatic calculus" ; rdfs:subClassOf obo:HP_0008775 . obo:HP_0034883 obo:IAO_0000115 "A reduction in the velocity of portal venous flow, generally measured by Doppler ultrasound. Portal venous flow is normally towards the liver with peak systolic velocities in the range of 20-40 cm/s." ; dc:date "2023-07-08T18:47:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced portal venous flow" ; a owl:Class ; rdfs:label "Decreased portal vein velocity" ; rdfs:subClassOf obo:HP_0031865 . obo:HP_0034884 obo:IAO_0000115 "A swelling or enlargment localized to the cervis of the uterus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-08T18:50:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine cervix mass" ; rdfs:subClassOf obo:HP_0012888 . obo:HP_0034885 obo:IAO_0000115 "The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for usine concentration, is outside the limits of normal." ; dc:date "2023-07-08T19:03:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary uromodulin level" ; rdfs:subClassOf obo:HP_0020129 . obo:HP_0034886 obo:IAO_0000115 "The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is below the lower limit of normal." ; dc:date "2023-07-08T19:05:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Uromodulin low in urine" ; a owl:Class ; rdfs:label "Decreased urinary uromodulin level" ; rdfs:subClassOf obo:HP_0034885 . obo:HP_0034887 obo:IAO_0000115 "The concentration of phenylacetylglutamine in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-07-08T20:56:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased urine phenylacetylglutamine level" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0034888 obo:IAO_0000115 "The concentration of guanidinoacetic acid in the urine, normalized for urine concentration, is below the lower limit of normal." ; dc:date "2023-07-08T21:00:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urine guanidinoacetic acid level" ; rdfs:subClassOf obo:HP_0033097 . obo:HP_0034889 obo:IAO_0000115 "Detection of DNA and RNA originating from an infectious agent (bacteria, viruses, parasites and fungi) in the urine." ; dc:date "2023-07-08T21:05:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive urine infectious agent nucleid acid test" ; rdfs:subClassOf obo:HP_0003110 . obo:HP_0034890 obo:IAO_0000115 "Detection of Cytomegalovirus (CMV) nucleic acid in the urine by a method such as polymerase chain reaction." ; dc:date "2023-07-08T21:07:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cytomegalovirus (CMV) PCR in urine positive", "Positive cytomegalovirus urine nucleic acid test" ; a owl:Class ; rdfs:label "Positive CMV urine nucleic acid test" ; rdfs:subClassOf obo:HP_0034889 . obo:HP_0034891 obo:IAO_0000115 "Detection of Neisseria gonorrhoeae nucleic acid in the urine by a method such as polymerase chain reaction." ; dc:date "2023-07-08T21:09:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Neisseria gonorrhoeae PCR positive in urine" ; a owl:Class ; rdfs:label "Positive Neisseria gonorrhoeae urine nucleic acid test" ; rdfs:subClassOf obo:HP_0034889 . obo:HP_0034892 obo:IAO_0000115 "Detection of enterovirus nucleic acid in the urine by a method such as polymerase chain reaction." ; dc:date "2023-07-08T21:11:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Enterovirus RT-PCR in urine" ; a owl:Class ; rdfs:label "Positive enterovirus urine nucleic acid test" ; rdfs:subClassOf obo:HP_0034889 . obo:HP_0034893 obo:IAO_0000115 "An increase in the level of glycine in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2023-07-08T21:17:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated brain glycine level by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0034894 obo:IAO_0000115 "An increase in the level of polyol compounds in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2023-07-08T21:20:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated brain polyol compounds by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0034895 obo:IAO_0000115 "An increase in the level of gamma-aminobutyric acid (GABA) in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2023-07-08T21:22:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated brain GABA by MRS" ; a owl:Class ; rdfs:label "Elevated brain gamma-aminobutyric acid by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0034896 obo:IAO_0000115 "Medical history of ingestion of anticoagulants prior to presentation." ; dc:date "2023-07-08T21:24:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "History of recent anticoagulant ingestion" ; rdfs:subClassOf obo:HP_4000144 . obo:HP_0034897 obo:IAO_0000115 "Concentration of antidiuretic hormone, also known as vasopressin, is below the lower limit of normal in the blood circulation." ; dc:date "2023-07-08T23:11:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating antidiuretic hormone concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034898 obo:IAO_0000115 "Concentration of growth hormone-releasing hormone above the upper limit of normal in the blood circulation." ; dc:date "2023-07-08T23:14:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating growth hormone-releasing hormone concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034899 obo:IAO_0000115 "Any deviation of the concentration of a protein in the amniotic fluid from normal limits" ; dc:date "2023-07-08T23:17:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal amniotic fluid protein concentration" ; rdfs:subClassOf obo:HP_0001560 . obo:HP_0034900 obo:IAO_0000115 "Concentration of alpha-fetoprotein in the amniotic fluid below lower limit of normal." ; dc:date "2023-07-08T23:18:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased amniotic fluid alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0034899 . obo:HP_0034901 obo:IAO_0000115 "Concentration of vitamin E in the blood circulation above the upper limit of normal." ; dc:date "2023-07-08T23:21:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating vitamin E concentration" ; rdfs:subClassOf obo:HP_0100514 . obo:HP_0034902 obo:IAO_0000115 "Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation outside of normal limits." ; dc:date "2023-07-08T23:22:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating calcitonin concentration" ; rdfs:subClassOf obo:HP_0100530 . obo:HP_0034903 obo:IAO_0000115 "Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation below the lower limit of normal." ; dc:date "2023-07-08T23:24:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Calcitonin low in blood" ; a owl:Class ; rdfs:label "Decreased circulating calcitonin concentration" ; rdfs:subClassOf obo:HP_0034902 . obo:HP_0034904 obo:IAO_0000115 "Concentration of thyrotropin releasing hormone below the lower limit of normal in the blood circulation." ; dc:date "2023-07-08T23:27:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating TRH concentration", "Thyrotropin releasing hormone (TRH) low in blood" ; a owl:Class ; rdfs:label "Decreased circulating thyrotropin releasing hormone concentration" ; rdfs:subClassOf obo:HP_0003117 . obo:HP_0034905 obo:IAO_0000115 "Concentration of uroporphyrin in the blood circulation above the upper limit of normal." ; dc:date "2023-07-08T23:30:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating uroporphyrin concentration" ; rdfs:subClassOf obo:HP_0034606 . obo:HP_0034906 obo:IAO_0000115 "Concentration of pentacarboxylporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-07-08T23:37:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Pentacarboxylporphyrin high in urine" ; a owl:Class ; rdfs:label "Increased urine pentacarboxylporphyrin level" ; rdfs:subClassOf obo:HP_0010473 . obo:HP_0034907 obo:IAO_0000115 "Concentration of hexacarboxylporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-07-08T23:38:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hexacarboxylporphyrin high in urine" ; a owl:Class ; rdfs:label "Increased urine hexacarboxylporphyrin level" ; rdfs:subClassOf obo:HP_0010473 . obo:HP_0034908 obo:IAO_0000115 "Concentration of dehydroepiandrosterone in the blood circulation above the upper limit of normal." ; dc:date "2023-07-08T23:41:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Dehydroepiandrosterone high in blood" ; a owl:Class ; rdfs:label "Increased circulating dehydroepiandrosterone concentration" ; rdfs:subClassOf obo:HP_0500022 . obo:HP_0034909 obo:IAO_0000115 "Concentration of coproporphyrin in erythrocytes above the upper limit of normal." ; dc:date "2023-07-08T23:44:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased erythrocyte coproporphyrin concentration" ; rdfs:subClassOf obo:HP_0034606 . obo:HP_0034910 obo:IAO_0000115 "Concentration of uroproporphyrin in erythrocytes above the upper limit of normal." ; dc:date "2023-07-08T23:45:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Uroporphyrin high in erythrocytes" ; a owl:Class ; rdfs:label "Increased erythrocyte uroproporphyrin concentration" ; rdfs:subClassOf obo:HP_0034606 . obo:HP_0034911 obo:IAO_0000115 "Concentration of apolipoprotein E below the lower limit of normal." ; dc:date "2023-07-08T23:47:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating apolipoprotein E concentration" ; rdfs:subClassOf obo:HP_0033459 . obo:HP_0034912 obo:IAO_0000115 "Concentration of apolipoprotein E above the upper limit of normal." ; dc:date "2023-07-08T23:49:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating apolipoprotein E concentration" ; rdfs:subClassOf obo:HP_0033460 . obo:HP_0034913 obo:IAO_0000115 "Reduction in the size of the acrosome of the head of spermatozoa." ; dc:date "2023-07-09T12:25:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus that is highly conserved throughout evolution. This acidic vacuole contains a number of hydrolytic enzymes that, when secreted, help the sperm penetrate the egg's coats. See Figure 23 of PMID:3311822." ; rdfs:label "Acrosomal hypoplasia" ; rdfs:subClassOf obo:HP_0012865 . obo:HP_0034914 obo:IAO_0000115 "Oocyte maturation arrest (OMA) can manifest as failed in vitro fetilization/intracytoplasmic sperm injection (IVF/ICSI) attempts using affected oocytes." ; dc:date "2023-07-09T12:27:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Oocyte maturation occurs through a series of molecular and morphological changes. Oocytes are initially arrested at the diplotene stage of prophase I, at which point they are referred to as germinal vesicle (GV) oocytes. Upon a surge in luteinizing hormone, GV oocytes exit prophase I and resume meiosis, and this is followed by chromatin condensation and breakdown of the nuclear envelope. Coupled with spindle formation and chromosome alignment, oocytes enter into meiosis I (when they are referred to as MI oocytes). MI is completed by extrusion of the first polar body. Oocytes then enter into meiosis II (when they are referred to as MII oocytes) but arrest at metaphase of MII until fertilization. In clinical in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), first polar body (PB1) oocytes are regarded as indicative of MII oocytes, which can be used for fertilization. Oocyte maturation arrest occurs at different stages, including the GV stage and MI, leading to female infertility." ; rdfs:label "Oocyte maturation arrest" ; rdfs:subClassOf obo:HP_0033338 . obo:HP_0034915 obo:IAO_0000115 "A structural anomaly of the anus." ; dc:date "2023-07-09T12:37:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal anus morphology" ; rdfs:subClassOf obo:HP_0004378, obo:HP_0025033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034916 obo:IAO_0000115 "A functional anomaly of the anus." ; dc:date "2023-07-09T12:39:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal anus physiology" ; rdfs:subClassOf obo:HP_0004378, obo:HP_0025032 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001245 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0034917 obo:IAO_0000115 "Reduced muscle tone of the sphincter of the anus." ; dc:date "2023-07-09T12:41:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Weak anal sphincter tone" ; rdfs:subClassOf obo:HP_0034916 . obo:HP_0034918 obo:IAO_0000115 "Diminished activity of the enzyme 2,4-dienoyl-CoA reductase in muscle tissue." ; dc:date "2023-07-09T12:48:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: 2,4-dienoyl-CoA reductase activity low" ; a owl:Class ; rdfs:label "Reduced muscle 2,4-dienoyl-CoA reductase activity" ; rdfs:subClassOf obo:HP_0034526 . obo:HP_0034919 obo:IAO_0000115 "Diminished activity of the enzyme 2,4-dienoyl-CoA reductase in liver tissue." ; dc:date "2023-07-09T12:58:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced liver 2,4-dienoyl-CoA reductase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034920 obo:IAO_0000115 "Inflammation of blood vessels in the mucosa of the nasal cavity." ; dc:date "2023-07-09T13:02:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasal mucosa vasculitis" ; rdfs:subClassOf obo:HP_0000433 . obo:HP_0034921 obo:IAO_0000115 "Pituitary blastoma is a distinctive anterior hypophyseal tumor of infants" ; dc:date "2023-07-09T13:05:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Pituitary blastoma presents in infants younger than 24 months, most frequently with Cushing syndrome and elevated adrenocorticotropin (ACTH) and occasionally with ophthalmoplegia, signs of increased intracranial pressure, diabetes insipidus, and thyrotropin deficit. An often large solid or cystic/solid mass arises from the sella with extension into the hypothalamus and may encompass the optic chiasm and/or cavernous sinuses. Pathologically, the tumors exhibit arrested pituitary development and uncontrolled proliferation and are composed of Rathke epithelium, folliculostellate cells, small primitive cells, and secretory cells with ACTH or, less often, growth hormone immunoexpression." ; rdfs:label "Pituitary blastoma" ; rdfs:subClassOf obo:HP_0011750 . obo:HP_0034922 obo:IAO_0000115 "Axonal spheroids are bubble-like biological features that form on most degenerating axons." ; dc:date "2023-07-09T13:09:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "They often contain cytoskeletal elements and organelles, and, depending on the pathological insult, can colocalize with disease-related proteins such as amyloid precursor protein (APP), ubiquitin, and motor proteins. Initial formation of axonal spheroids depends on the disruption of axonal and membrane tension governed by cytoskeleton structure and calcium levels. Shortly after spheroid formation, the engulfment signal, phosphatidylserine (PS), is exposed on the outer leaflet of spheroid plasma membrane, suggesting an important role for axonal spheroids in phagocytosis and debris clearance during degeneration." ; rdfs:label "Peripheral axon spheroid formation" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0034923 obo:IAO_0000115 "Activity of the enzyme carboxylesterase 1 in liver tissue below the lower limit of normal." ; dc:date "2023-07-09T13:14:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced liver carboxylesterase 1 activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034924 obo:IAO_0000115 "A structural anomaly of the dermis, the layer of skin that lies beneath the epidermis and above the subcutaneous layer." ; dc:date "2023-07-09T13:20:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal dermis morphology" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0034925 obo:IAO_0000115 "Deposition of a largely amorphous hyaline (transparent and homogeneous) substance around blood vessels in the dermis layer of the skin." ; dc:date "2023-07-09T13:21:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 4 of PMID:11298373" ; rdfs:label "Perivascular dermis hyaline deposition" ; rdfs:subClassOf obo:HP_0034924 . obo:HP_0034926 obo:IAO_0000115 "Deposition of a largely amorphous hyaline (transparent and homogeneous) substance around blood vessels in the wall of the small intestine." ; dc:date "2023-07-09T13:30:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Perivascular small intestinal hyaline deposition" ; rdfs:subClassOf obo:HP_0002244 . obo:HP_0034927 obo:IAO_0000115 "Abnormally large keratohyalin granules (KHG). KHG are typically present in the stratum granulosum of the epidermal layer of the skin (and epithelium of the mucosae). KHG are protein structures found in the keratinocytes of the stratum granulosum." ; dc:date "2023-07-09T14:05:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The chief function of keratohyaline granules seems to be cross-linking of keratin filaments which creates the tight barrier that is the epidermis." ; rdfs:label "Large keratohyaline granules" ; rdfs:subClassOf obo:HP_0033806, obo:HP_0034702 . obo:HP_0034928 obo:IAO_0000115 "Reduced amount of lipoic acid in muscle tissue." ; dc:date "2023-07-09T14:16:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Muscle biopsy: lipoic acid low" ; a owl:Class ; rdfs:label "Decreased muscle lipoic acid content" ; rdfs:subClassOf obo:HP_0034370 . obo:HP_0034929 obo:IAO_0000115 "Activity of cystathionine gamma-lyase in the liver below the lower limit of normal." ; dc:date "2023-07-09T14:17:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced hepatic cystathionase activity" ; a owl:Class ; rdfs:label "Reduced hepatic cystathionine gamma-lyase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034930 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the digestive system." ; dc:date "2023-07-09T14:37:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Digestive system neoplasm" ; rdfs:subClassOf obo:HP_0025031 . obo:HP_0034931 obo:IAO_0000115 "Arthrosis, i.e., of degenerative joint disease, affecting the lumbar vertebral column." ; dc:date "2023-07-09T21:14:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lumbar spine osteoarthritis" ; a owl:Class ; rdfs:comment "When osteoarthritis affects the spine, it is known as spondylosis." ; rdfs:label "Lumbar spondylosis" ; rdfs:subClassOf obo:HP_0100712 . obo:HP_0034932 obo:IAO_0000115 "Activity of the enzyme acid maltase (also known as alpha-1,4-glucosidase) below the lower limit of normal." ; dc:date "2023-07-09T21:19:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased alpha-1,4-glucosidase activity" ; a owl:Class ; rdfs:comment "This finding is characteristic of Glycogen storage disease II (Pompe disease)." ; rdfs:label "Decreased circulating acid maltase activity" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0034933 obo:IAO_0000115 "The concentration of ribitol in the blood circulation is above the upper limit of normal." ; dc:date "2023-07-09T21:27:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased circulating ribitol concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0034934 obo:IAO_0000115 "Concentration of 7-dehydrocholesterol in the blood circulation outside the limits of normal." ; dc:date "2023-07-09T21:28:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating 7-dehydrocholesterol concentration" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0034935 obo:IAO_0000115 "Concentration of 7-dehydrocholesterol in the blood circulation below the lower limit of normal." ; dc:date "2023-07-09T21:31:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating 7-dehydrocholesterol concentration" ; rdfs:subClassOf obo:HP_0034934 . obo:HP_0034936 obo:IAO_0000115 "Concentration of lathosterol in the blood circulation above the upper limit of normal." ; dc:date "2023-07-09T21:33:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Lathosterol is an intermeditate in the synthesis of cholesterol." ; rdfs:label "Elevated circulating lathosterol concentration" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0034937 obo:IAO_0000115 "Concentration of desmosterol in the blood circulation above the upper limit of normal." ; dc:date "2023-07-09T21:38:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating desmosterol concentration" ; rdfs:subClassOf obo:HP_0003107 . obo:HP_0034938 obo:IAO_0000115 "Concentration of sialic acid in the blood circulation below the lower limit of normal." ; dc:date "2023-07-09T21:43:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased circulating sialic acid concentration" ; rdfs:subClassOf obo:HP_0011013 . obo:HP_0034939 obo:IAO_0000115 "The synovial fluid (also known as synovia, i.e., the fluid found in the cavities of synovial joints) contains increased quantities of white blood cells." ; dc:date "2023-07-10T10:13:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Purulent synovial fluid" ; rdfs:subClassOf obo:HP_0001367 . obo:HP_0034940 obo:IAO_0000115 "The presence of inclusion bodies within the cytoplasm of muscle cells that demonstrate immunoreactivity for calsequestrin 1." ; dc:date "2023-07-10T10:38:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Muscle fiber calsequestrin 1-containing inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0034941 obo:IAO_0000115 "A myxoma (A benign tumor composed of myxomatous tissue composed of loosely-arranged spindle, polygonal, and stellate cells) localized to the palate. Clinically, such tumors may present as a sessile nodule on the hard palate." ; dc:date "2023-07-10T10:43:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Palatine myxoma" ; rdfs:subClassOf obo:HP_0031366 . obo:HP_0034942 obo:IAO_0000115 "A myxoma (tumor of primitive connective tissue) localized in the vagina." ; dc:date "2023-07-10T11:02:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vaginal myxoma" ; rdfs:subClassOf obo:HP_0100650 . obo:HP_0034943 obo:IAO_0000115 "Abnormally reduced amount of collagen fibers in the dermis." ; dc:date "2023-07-10T11:07:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 4C of PMID:29606302." ; rdfs:label "Decreased dermal collagen" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0034944 obo:IAO_0000115 "Abnormal shape of keratohyaline granules in dermal keratinocytes." ; dc:date "2023-07-10T11:18:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Normal keratohyaline granules demonstrate a stellate and angulated shape See Figure S2 (Electron microscopy of the granular layer) of PMID:29758285." ; rdfs:label "Irregularly shaped keratohyaline granules" ; rdfs:subClassOf obo:HP_0033806 . obo:HP_0034945 obo:IAO_0000115 "Tubular shadows are characterised by a complete absence of cells in the testicular tubules, meaning that germ cells as well as somatic Sertoli cells are absent. The cells have been replaced by hyalinization." ; dc:date "2023-07-10T11:23:34Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; a owl:Class ; rdfs:label "Tubular shadows" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0034946 obo:IAO_0000115 "Presence of many apocrine hidrocystoma (cysts) on the margins of the eyelids." ; dc:date "2023-07-10T11:27:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Multiple eyelid-margin apocrine hidrocystomas" ; a owl:Class ; rdfs:label "Multiple eyelid margin cysts" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0034947 obo:IAO_0000115 "The fibrous sheath is a structure in the midpiece of the sperm flagellum surrounding the outer dense fibers. It comprises two longitudinal columns and tranverse ribs. In case of altered location of the longitudinal column in the fibrous sheath the symmetrical structure is lost, most commonly with the columns not being opposite to each other, which can be visualised by electron microscopy." ; dc:date "2023-07-10T11:39:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Altered location of the longitudinal column in the fibrous sheath" ; rdfs:subClassOf obo:HP_0012868 . obo:HP_0034948 obo:IAO_0000115 "A myxoma (tumor of primitive connective tissue) localized to the uterus." ; dc:date "2023-07-10T11:49:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine myxoma" ; rdfs:subClassOf obo:HP_0010784 . obo:HP_0034949 obo:IAO_0000115 "A myxoma (tumor of primitive connective tissue) localized to the the cervix of the uterus." ; dc:date "2023-07-10T11:51:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine cervix myxoma" ; rdfs:subClassOf obo:HP_0010784 . obo:HP_0034950 obo:IAO_0000115 "Penetrance describes the proportion of genotype positive individuals that develop disease given a lifespan of 80 years. For example, penetrance of Neurofibromatosis type 1 is close to 100%." ; dc:date "2023-07-15T10:51:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Description of conditions in which all individuals with a given genotype exhibit the disease within a lifespan of 80 years." ; rdfs:label "Typified by complete penetrance" ; rdfs:subClassOf obo:HP_0034335 . obo:HP_0034951 obo:IAO_0000115 "A rare benign chondroid and osteoid matrix-producing neoplasm of bone characterized by extensive myxoid changes. OMX originate from bony cortices and have been observed in the nasal region, as well as the tibia and radius." ; dc:date "2023-07-15T10:53:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Osteochondromyxoma is a rare manifestation of Carney complex." ; rdfs:label "Osteochondromyxoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0034952 obo:IAO_0000115 "A low-grade central nervous system tumor composed of dysplastic ganglion cells, usually presenting in children or young adults and located in the cerebral hemispheres." ; dc:date "2023-07-15T11:01:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gangliocytoma" ; rdfs:subClassOf obo:HP_0030693 . obo:HP_0034953 obo:IAO_0000115 "A gastrinoma, a neuroendocrine tumors characterized by the secretion of gastrin with resultant excessive gastric acid production, that is localized to the duodenum." ; dc:date "2023-07-15T11:03:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Duodenal gastrinoma" ; rdfs:subClassOf obo:HP_0100833 . obo:HP_0034954 obo:IAO_0000115 "A primary thymic neuroendocrine tumor." ; dc:date "2023-07-15T11:05:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thymic carcinoid tumor" ; rdfs:subClassOf obo:HP_0100521 . obo:HP_0034955 obo:IAO_0000115 "Count of eosinophils in the bone marrow above the upper limit of normal." ; dc:date "2023-07-15T11:07:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophils increased in bone marrow" ; a owl:Class ; rdfs:comment "See Figure 1E of PMID:27684977." ; rdfs:label "Bone marrow eosinophilia" ; rdfs:subClassOf obo:HP_0012135 . obo:HP_0034956 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by treatment with lithium." ; dc:date "2023-07-15T11:11:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by lithium exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0034957 obo:IAO_0000115 "Activity of glycogen debrancher enzyme (also known as amylo-1,6-glucosydase, 4-alpha-glucantransferase) in liver tissue below the lower limit of normal." ; dc:date "2023-07-15T11:12:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Glycogen debrancher enzyme degrades glycogen branches and thereby releases glucose in a two step reaction. Debranching enzyme activity can be measured in either blood cells (leukocytes or erythrocytes), skin fibroblasts, or liver or muscle biopsy." ; rdfs:label "Reduced hepatic glycogen debrancher enzyme activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034958 obo:IAO_0000115 "Insertion of the neck and midpiece into the head of a spermatozoon on an axis that diverges from the midline axis of the spermatozoon head. This term applies if the proportion of spermatozoa with this defect is above the upper limit of normal." ; dc:date "2023-07-15T11:53:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Asymmetrical insertion of sperm neck" ; a owl:Class ; rdfs:label "Asymmetrical insertion of the midpiece into the head" ; rdfs:subClassOf obo:HP_0012867 . obo:HP_0034959 obo:IAO_0000115 "Sharply angled insertion of the neck and midpiece into the head of a spermatozoon. This term applies if the proportion of spermatozoa with this feature is above the upper limit of normal." ; dc:date "2023-07-15T12:04:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bent sperm neck" ; rdfs:subClassOf obo:HP_0012866 . obo:HP_0034960 obo:IAO_0000115 "The concentration of 3,6-epoxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2023-07-15T12:57:48Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated urine 3,6-epoxydicarboxylic acid level" ; rdfs:subClassOf obo:HP_0003215 . obo:HP_0034961 obo:IAO_0000115 "Presence of biliary sludge (a mixture of particulate solids that have precipitated from bile) in the gallbladder. Such sediment consists of cholesterol crystals, calcium bilirubinate pigment, and other calcium salts. Sludge is usually detected on transabdominal ultrasonography." ; dc:date "2023-07-15T13:12:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gallbladder biliary sludging" ; rdfs:subClassOf obo:HP_0012437 . obo:HP_0034962 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by treatment with amiodarone." ; dc:date "2023-07-15T13:14:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exacerbated by amiodarone exposure" ; rdfs:subClassOf obo:HP_4000176 . obo:HP_0034963 obo:IAO_0000115 "A swelling or enlargment localized to the ureter. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-15T20:40:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Ureteral mass" ; rdfs:subClassOf obo:HP_0025633 . obo:HP_0034964 obo:IAO_0000115 "Width of the cavum septum pellucidum above the upper limit of normal, which is defined as a separation of greater than one cm of the leaves of the cavum septum pellucidum." ; dc:date "2023-07-15T20:41:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Wide cavum septum pellucidum" ; rdfs:subClassOf obo:HP_0007375 . obo:HP_0034965 obo:IAO_0000115 "Underdevelopment of the trochlear nerve, which is the fourth cranial nerve and one of the ocular motor nerves that controls eye movement." ; dc:date "2023-07-15T20:50:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypoplastia of cranial nerve IV" ; a owl:Class ; rdfs:label "Hypoplastic trochlear nerve" ; rdfs:subClassOf obo:HP_0001291 . obo:HP_0034966 obo:IAO_0000115 "A closed sac of tissue (cyst) located in the thymus. Thymic cysts are a rare, benign anomaly, are usually asymptomatic, and mostly occur in the anterior mediastinum ." ; dc:date "2023-07-15T20:54:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thymic cyst" ; rdfs:subClassOf obo:HP_0000777 . obo:HP_0034967 obo:IAO_0000115 "A closed sack of tissue (cyst) located in the uterus." ; dc:date "2023-07-15T20:59:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Uterine cyst" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0034968 obo:IAO_0000115 "A swelling or enlargment localized to the urinary bladder. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-15T21:00:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Urinary bladder mass" ; rdfs:subClassOf obo:HP_0025487 . obo:HP_0034969 obo:IAO_0000115 "A series of indentations or erosions on a normally smooth margin of the inner layer of the cortex (i.e. the endosteum) of bones." ; dc:date "2023-07-15T22:00:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Endosteal scalloping" ; rdfs:subClassOf obo:HP_0000940 . obo:HP_0034970 obo:IAO_0000115 "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the urinary bladder." ; dc:date "2023-07-15T22:01:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Urinary bladder hamartoma" ; rdfs:subClassOf obo:HP_0009725, obo:HP_0010566 . obo:HP_0034971 obo:IAO_0000115 "A swelling or enlargment localized to the peritoneal cavity. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-15T22:07:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peritoneal mass" ; rdfs:subClassOf obo:HP_0002585 . obo:HP_0034972 obo:IAO_0000115 "A swelling or enlargment localized to the Fallopian tube. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined." ; dc:date "2023-07-15T22:08:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fallopian tube mass" ; rdfs:subClassOf obo:HP_0011027 . obo:HP_0034973 obo:IAO_0000115 "Congenital absence of the pyramids, that is, of the paired structures located at the medial aspect of the ventral medulla that flank the anterior median fissure." ; dc:date "2023-07-15T22:11:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia of the pyramids of the medulla oblongata" ; rdfs:subClassOf obo:HP_0011441 . obo:HP_0034974 obo:IAO_0000115 "A deformity of the posterior skull with bulging of the midportion of the occipital bone that is often associated with a benign variant of the mendosal suture." ; dc:date "2023-07-15T22:37:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Bathrocephaly" ; rdfs:subClassOf obo:HP_0002683 . obo:HP_0034975 obo:IAO_0000115 "Downward pointing exostoses of the occipital bone situated in the tendinous insertions of the sternocleidomastoid and trapezius muscles." ; dc:date "2023-07-15T22:41:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 2 of PMID:31336972." ; rdfs:label "Occipital horn" ; rdfs:subClassOf obo:HP_0012294 . obo:HP_0034976 obo:IAO_0000115 "A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." ; dc:date "2023-07-16T12:39:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 1 and 2 of PMID:25250085." ; rdfs:label "Absent pituitary stalk" ; rdfs:subClassOf obo:HP_0034977 . obo:HP_0034977 obo:IAO_0000115 "A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." ; dc:date "2023-07-16T12:45:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pituitary stalk morphology" ; rdfs:subClassOf obo:HP_0000864 . obo:HP_0034978 obo:IAO_0000115 "A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." ; dc:date "2023-07-16T12:45:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interrupted pituitary stalk" ; rdfs:subClassOf obo:HP_0034977 . obo:HP_0034979 obo:IAO_0000115 "Unintentional movement in one area of the face produced during intentional movement of another area of the face." ; dc:date "2023-07-16T12:50:35Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; a owl:Class ; rdfs:comment "For instance, facial synkinesis may manifest as hypertonic contractures and synkinetic movements such as eye closure with volitional movement of the mouth or midfacial movement during volitional or reflexive eye closure." ; rdfs:label "Facial synkinesis" ; rdfs:subClassOf obo:HP_0034980 . obo:HP_0034980 obo:IAO_0000115 "Unintentional movement in one area of the body produced during intentional movement of another area of the body." ; dc:date "2023-07-16T12:53:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Synkinesis" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0034981 obo:IAO_0000115 "History of exposure to birds." ; dc:date "2023-07-16T12:58:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exposure to birds" ; rdfs:subClassOf obo:HP_4000110 . obo:HP_0034982 obo:IAO_0000115 "Loss of sensation to the area of buttocks, perianal space and thighs." ; dc:date "2023-07-16T13:02:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature may be observed with cauda equina syndrome as a collection of acute symptoms mostly occurring secondary to a large disc herniations leading to neuropathy of multiple lumbar and sacral nerve roots, or with spinal epidural abscess." ; rdfs:label "Perianal anethesia" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0034983 obo:IAO_0000115 "Instillation of 2.5% phenylephrine drops into the eye does not induce blanching of eye redness. Failure to blanch suggests redness caused by scleral vessel engorgement (e.g., scleritis) or extravascular cause (e.g., hemorrhage), not episcleritis or conjunctivitis." ; dc:date "2023-07-16T13:05:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Phenylephrine does not induce blanching of eye redness" ; rdfs:subClassOf obo:HP_0100533 . obo:HP_0034984 obo:IAO_0000115 "A history of exposure during pregnancy of the mother of a fetus or child to ethanol (alcohol)." ; dc:date "2023-07-16T13:18:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fetal alcohol exposure" ; rdfs:subClassOf obo:HP_0034756 . obo:HP_0034985 obo:IAO_0000115 "Diminished ability of cells to transport cobalamine from the extracellular space to the cytoplasm." ; dc:date "2023-07-16T15:45:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cobalamin (Cbl. also known as vitamin B12) plays a role in the recycling of folate for single carbon exchange reactions, purine and pyrimidine synthesis, and methylation of homocysteine for the production of S-adenosylmethionine. The absorption, blood transport and cellular uptake of Cbl are complex processes involving multiple proteins and receptors. Transcobalamine binds to Cbl to protect it from acid degradation in the stomach." ; rdfs:label "Reduced cellular cobalamin uptake" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_0034986 obo:IAO_0000115 "A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the brainstem." ; dc:date "2023-07-16T15:59:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal necrotic brainstem lesion" ; rdfs:subClassOf obo:HP_0002363 . obo:HP_0034987 obo:IAO_0000115 "A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the optic nerve." ; dc:date "2023-07-16T16:02:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal necrotic optic nerve lesion" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0034988 obo:IAO_0000115 "A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the thalamus." ; dc:date "2023-07-16T16:03:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Focal necrotic thalamus lesion" ; rdfs:subClassOf obo:HP_0010663 . obo:HP_0034989 obo:IAO_0000115 "Accumulation of fluid in the interstitial spaces of the skin. This finding can be appreciated my microscopic examination of a skin biopsy." ; dc:date "2023-07-16T16:06:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Interstitial dermal edema" ; rdfs:subClassOf obo:HP_0034924 . obo:HP_0034990 dc:date "2023-07-18T17:29:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abduction contracture of the shoulder" ; a owl:Class ; rdfs:comment "A type of shoulder contracture characterized by decreased adduction movement of shoulder, that is, by a by a chronic reduction in active and passive ability to move the arm via the shoulder joint away from the median plane of the body." ; rdfs:label "Shoulder abduction contracture" ; rdfs:subClassOf obo:HP_0034665 . obo:HP_0034991 obo:IAO_0000115 "A type of shoulder contracture characterized by decreased internal rotation of shoulder, that is, by a chronic reduction in active and passive ability to internally rotate the humerus at the shoulder joint (if the arm is flexed at the elbow, Internal rotation of the shoulder rotates the forearm towards the center of the body)." ; dc:date "2023-07-18T17:32:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "External rotation contracture of the shoulder joint" ; a owl:Class ; rdfs:label "Shoulder external rotation contracture" ; rdfs:subClassOf obo:HP_0034665 . obo:HP_0034992 obo:IAO_0000115 "A type of thumb contracture characterized by a chronic reduction in active and passive ability of the metacarpal-phalangeal and/or interphalangeal joints of the thumb to bring from medial side to neutral position, where the neutral position for the thumb is when the distal and proximal segments of the thumb joint are in linear alignment." ; dc:date "2023-07-18T17:41:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Thumb adduction contracture" ; rdfs:subClassOf obo:HP_0009600 . obo:HP_0034993 dc:date "2023-07-18T17:59:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hip internal rotation contracture" ; rdfs:subClassOf obo:HP_0003273 . obo:HP_0034994 dc:date "2023-07-19T11:20:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated circulating saccharopine concentration" ; rdfs:subClassOf obo:HP_0033108 . obo:HP_0034995 obo:IAO_0000115 "Activity of fructose-1,6-bisphosphatase (EC 3.1.3.11) in the liver below the lower limit of normal." ; dc:date "2023-07-19T11:29:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic fructose-1,6-bisphosphatase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034996 obo:IAO_0000115 "Activity of carbamoylphosphate synthetase in the liver below the lower limit of normal." ; dc:date "2023-07-19T11:33:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic carbamoylphosphate synthetase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0034997 obo:IAO_0000115 "Reduced number of small nerve fibers in the skin." ; dc:date "2023-07-19T11:40:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Small fibers travel too slowly, and their conduction responses cannot be captured by a nerve conduction study, which is a routine test performed to evaluate large sensory and motor nerve fibers. Therefore, a skin biopsy is often used to assess small sensory nerve fibers in the skin. Skin biopsy is a minimally invasive procedure that may also be used to evaluate intraepidermal nerve fiber density. Skin specimens are typically obtained by a 3 mm punch biopsy at the distal leg and thigh and are then sent for laboratory analysis. Small fiber neuropathy may be diagnosed if the intraepidermal nerve fiber density is less than normal." ; rdfs:label "Reduced intraepidermal small nerve fiber density" ; rdfs:subClassOf obo:HP_0000759 . obo:HP_0034998 obo:IAO_0000115 "A developmental defect characterized by the presence of a supernumerary femoral artery." ; dc:date "2023-07-19T11:42:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Femoral artery duplication" ; rdfs:subClassOf obo:HP_0035012 . obo:HP_0034999 obo:IAO_0000115 "Collagen VII is the major molecular constituent of anchoring fibrils in the skin. Collagen VII is synthesized as three identical pro-alpha1(VII) polypeptide chains, which are hydroxylated and glycosylated in a coordinated manner and then fold into triple-helical procollagen VII in the endoplasmic reticulum (ER). Mature collagen VII undergoes a multistep fibril polymerization process to form the anchoring fibrils. Mutant pro-alpha1(VII) polypeptide chains or procollagen VII molecules do not pass the ER quality control and are retained in the ER or designated for ubiquitin-proteasome degradation resulting in reduced amounts of collagen VII in the skin." ; dc:date "2023-07-19T11:51:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 2B of PMID:8288900." ; rdfs:label "Intracellular accumulation of collagen VII" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0035000 obo:IAO_0000115 "Diminished amount of the anchoring fibrils in the basement membrane zone that normally attach the epithelium to the basement membrane." ; dc:date "2023-07-19T12:03:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced reticular lamina anchoring fibril density" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0035001 obo:IAO_0000115 "Diminished amount of the anchoring filaments that normally bridge the lamina lucida and insert into the lamina densa in the cutaneous basement membrane zone." ; dc:date "2023-07-19T12:06:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced lamina lucida anchoring filament density" ; rdfs:subClassOf obo:HP_0031512 . obo:HP_0035002 obo:IAO_0000115 "Amount of keratin 5 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy." ; dc:date "2023-07-19T12:12:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced epidermal keratin 5 protein expression" ; rdfs:subClassOf obo:HP_0035004 . obo:HP_0035003 obo:IAO_0000115 "Amount of keratin 14 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy." ; dc:date "2023-07-19T12:12:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced epidermal keratin 14 protein expression" ; rdfs:subClassOf obo:HP_0035004 . obo:HP_0035004 obo:IAO_0000115 "Amount of one or more keratins in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy." ; dc:date "2023-07-19T12:12:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced epidermal keratin protein expression" ; rdfs:subClassOf obo:HP_0034573 . obo:HP_0035005 obo:IAO_0000115 "Activity of alanine-glyoxylate aminotransferase in the liver below the lower limit of normal." ; dc:date "2023-07-19T12:23:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced hepatic alanine-glyoxylate aminotransferase activity" ; rdfs:subClassOf obo:HP_0034685 . obo:HP_0035006 obo:IAO_0000115 "Presence of an increased amount of blood in the hepatic capillaries." ; dc:date "2023-07-19T12:26:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Sinusoidal dilatation and congestion (SDC) in liver biopsy is often the result of venous outflow impairment. This impairment can occur at the level of the small hepatic veins (veno-occlusive disease), large hepatic veins (Budd-Chiari syndrome), or the heart (right-sided heart failure, tricuspid valve disease, constrictive pericarditis). See Figure in PMID:15270610" ; rdfs:label "Hepatic sinusoidal dilatation" ; rdfs:subClassOf obo:HP_0030146 . obo:HP_0035007 obo:IAO_0000115 "The cross-sectional size (diameter) of the midpiece of the spermatozoon is below the lower limit of normal. This term applies if the proportion of spermatozoa with this defect is above the upper limit of normal." ; dc:date "2023-07-19T21:14:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Thin spermatozoon neck" ; a owl:Class ; rdfs:label "Thin spermatozoon midpiece" ; rdfs:subClassOf obo:HP_0012867 . obo:HP_0035008 obo:IAO_0000115 "Increased width of the midpiece of the spermatozoon. The midpiece is the structure that is located between the head and the flagella (tail) of the spermatozoon. This term applies if the width of the midpiece increases progressively from the flagella to the head and if the proportion of individual spermatozoa with this anomaly is above the upper limit of normal." ; dc:date "2023-07-19T21:18:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "See Figure 2.10i of the WHO laboratory manual for the examination and processing of human semen, Sixth edition (2021)." ; rdfs:label "Thick spermatozoon midpiece insertion" ; rdfs:subClassOf obo:HP_0012867 . obo:HP_0035009 obo:IAO_0000115 "A type of shoulder contracture characterized by a chronic reduction in the active and passive ability to abduct the shoulder. This results in the shoulders being closer to midline. The affected individual is not able to position the shoulders away from the body." ; dc:date "2023-07-19T21:25:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Adduction contracture of the shoulder" ; a owl:Class ; rdfs:label "Shoulder adduction contracture" ; rdfs:subClassOf obo:HP_0034665 . obo:HP_0035010 obo:IAO_0000115 "Exposure to a substance that results from the performance of an employee's duties." ; dc:date "2023-07-19T21:37:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Occupational exposure history" ; rdfs:subClassOf obo:HP_4000110 . obo:HP_0035011 obo:IAO_0000115 "A history of exposure to silver that has occured in relation to performance of job duties." ; dc:date "2023-07-19T21:38:37Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Occupational silver exposure" ; rdfs:subClassOf obo:HP_0035010 . obo:HP_0035012 obo:IAO_0000115 "Any structural abnormality of the femoral artey, a large blood vessel that provides oxygenated blood to lower extremity structures and in part to the lower anterior abdominal wall." ; dc:date "2023-07-20T20:50:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal femoral artery morphology" ; rdfs:subClassOf obo:HP_0011004 . obo:HP_0035013 dc:date "2023-07-20T20:55:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal extrahepatic bile duct morphology" ; rdfs:subClassOf obo:HP_0012440 . obo:HP_0035014 obo:IAO_0000115 "Accumulation of fibrous connective tissue (collagen) in the extrahepatic bile ducts." ; dc:date "2023-07-20T21:02:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Extrahepatic bile duct fibrosis" ; rdfs:subClassOf obo:HP_0035013 . obo:HP_0040004 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022500" ; a owl:Class ; rdfs:label "Abnormality of corneal shape" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040006 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022499" ; a owl:Class ; rdfs:label "Mortality/Aging" ; rdfs:subClassOf obo:HP_0031797 . obo:HP_0040007 obo:IAO_0000115 "Lack of skin pigmentation (coloring) of the chest." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022498" ; oboInOwl:hasExactSynonym "Lack of skin coloring on chest", "Lack of skin colouring on chest" ; a owl:Class ; rdfs:label "Absent pigmentation of chest" ; rdfs:subClassOf obo:HP_0200098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001868 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040008 dcterms:creator ; oboInOwl:hasBroadSynonym "Failure of development of facial skeleton" ; oboInOwl:hasDbXref "UMLS:C1385254", "UMLS:C4022497", "UMLS:C4280300", "UMLS:C4280301" ; oboInOwl:hasExactSynonym "Absence of facial bones", "Agenesis of facial bones", "Aplasia of facial skeleton", "Failure of development of facial bones" ; oboInOwl:hasNarrowSynonym "Missing facial bones" ; a owl:Class ; rdfs:label "Aplasia of facial bones" ; rdfs:subClassOf obo:HP_0034261 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003462 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040009 obo:IAO_0000115 "Abnormal keratinization of the epidermal stratum coreum (horny layer) with increased keratin formation, preservation of the nuclei in the superficial cells, and absence of the stratum granulosum." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:125554003", "UMLS:C1265968" ; a owl:Class ; rdfs:label "Hyperparakeratosis" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0001036 . obo:HP_0040010 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022496" ; a owl:Class ; rdfs:label "Small posterior fossa" ; rdfs:subClassOf obo:HP_0000932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008788 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040011 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022495" ; a owl:Class ; rdfs:label "Flat posterior fossa" ; rdfs:subClassOf obo:HP_0000932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008788 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040012 obo:IAO_0000115 "Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D019457", "UMLS:C0376628" ; oboInOwl:hasExactSynonym "High frequency of chromosome breaks in lymphocytes", "Increased chromosomal breakage", "Increased chromosomal breakage rate", "Multiple chromosomal breaks", "Tendency to chromosomal breakage" ; a owl:Class ; rdfs:label "Chromosome breakage" ; rdfs:subClassOf obo:HP_0003220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0031052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040013 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022493" ; a owl:Class ; rdfs:label "Decreased mitochondrial number" ; rdfs:subClassOf obo:HP_0012102 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040014 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022492" ; a owl:Class ; rdfs:label "Increased mitochondrial number" ; rdfs:subClassOf obo:HP_0012102 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005739 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040015 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022491" ; a owl:Class ; rdfs:label "Increased activity of mitochondrial respiratory chain" ; rdfs:subClassOf obo:HP_0011922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0005746 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040016 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022490" ; oboInOwl:hasExactSynonym "Prominent tailbone" ; a owl:Class ; rdfs:label "Prominent coccyx" ; rdfs:subClassOf obo:HP_0008519 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040017 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022489" ; oboInOwl:hasExactSynonym "Protruding tailbone" ; a owl:Class ; rdfs:label "Protruding coccyx" ; rdfs:subClassOf obo:HP_0008519 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001598 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040018 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of big toe" ; oboInOwl:hasDbXref "UMLS:C4022488", "UMLS:C4280299" ; a owl:Class ; rdfs:label "Clinodactyly of hallux" ; rdfs:subClassOf obo:HP_0001863, obo:HP_0010051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003631 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040019 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of finger" ; oboInOwl:hasDbXref "SNOMEDCT_US:17268007", "UMLS:C0265610", "UMLS:C4280298" ; a owl:Class ; rdfs:label "Finger clinodactyly" ; rdfs:subClassOf obo:HP_0004097, obo:HP_0030084 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040020 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022487" ; a owl:Class ; rdfs:label "Radial deviation of the 5th finger" ; rdfs:subClassOf obo:HP_0009179, obo:HP_0009466 . obo:HP_0040021 obo:IAO_0100001 "HP:0001234" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Radial deviation of the thumb" ; owl:deprecated true . obo:HP_0040022 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of index finger" ; oboInOwl:hasDbXref "UMLS:C4022486" ; oboInOwl:hasExactSynonym "Second finger clinodactyly" ; a owl:Class ; rdfs:label "Clinodactyly of the 2nd finger" ; rdfs:subClassOf obo:HP_0009468, obo:HP_0040019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040023 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of thumb" ; oboInOwl:hasDbXref "UMLS:C1856888", "UMLS:C4280297" ; a owl:Class ; rdfs:label "Clinodactyly of the thumb" ; rdfs:subClassOf obo:HP_0009603, obo:HP_0040019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001463 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040024 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of middle finger" ; oboInOwl:hasDbXref "UMLS:C4022485", "UMLS:C4280296" ; a owl:Class ; rdfs:label "Clinodactyly of the 3rd finger" ; rdfs:subClassOf obo:HP_0009317, obo:HP_0040019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040025 dcterms:creator ; oboInOwl:hasBroadSynonym "Curvature of ring finger" ; oboInOwl:hasDbXref "UMLS:C4022484", "UMLS:C4280295" ; a owl:Class ; rdfs:label "Clinodactyly of the 4th finger" ; rdfs:subClassOf obo:HP_0009273, obo:HP_0040019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002177 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003624 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040030 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022483" ; a owl:Class ; rdfs:label "Chorioretinal hypopigmentation" ; rdfs:subClassOf obo:HP_0007661 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0040031 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022482" ; a owl:Class ; rdfs:label "Chorioretinal hyperpigmentation" ; rdfs:subClassOf obo:HP_0007661 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0040032 dcterms:creator ; oboInOwl:hasBroadSynonym "Small upper eyelid" ; oboInOwl:hasDbXref "UMLS:C4022481" ; oboInOwl:hasExactSynonym "Decreased size of upper eyelid", "Underdevelopment of upper eyelid" ; oboInOwl:hasNarrowSynonym "Short upper eyelid" ; oboInOwl:hasRelatedSynonym "Hypotrophic upper eyelid" ; a owl:Class ; rdfs:label "Hypoplasia of the upper eyelids" ; rdfs:subClassOf obo:HP_0430009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001712 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040033 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022480" ; oboInOwl:hasExactSynonym "Absent/small 5th long bone of foot", "Absent/underdeveloped 5th long bone of foot" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the fifth metatarsal bone" ; rdfs:subClassOf obo:HP_0001964, obo:HP_0008089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003654 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040034 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022479" ; oboInOwl:hasExactSynonym "Abnormality of the 2nd long bone of foot" ; a owl:Class ; rdfs:label "Abnormality of the second metatarsal bone" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003651 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040035 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022478" ; oboInOwl:hasExactSynonym "Abnormality of the 4th long bone of foot" ; a owl:Class ; rdfs:label "Abnormality of the fourth metatarsal bone" ; rdfs:subClassOf obo:HP_0001832 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003653 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040036 obo:IAO_0000115 "Thickened fingernails." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022477" ; oboInOwl:hasExactSynonym "Overgrowth and curving of fingernail" ; a owl:Class ; rdfs:label "Onychogryposis of fingernail" ; rdfs:subClassOf obo:HP_0001805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000591 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040037 obo:IAO_0100001 "HP:0012742" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Thin fingernail (obsolete)" ; owl:deprecated true . obo:HP_0040038 obo:IAO_0100001 "HP:0012746" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Thin toenail" ; owl:deprecated true . obo:HP_0040039 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C3553044" ; oboInOwl:hasExactSynonym "Detachment of fingernails", "Onycholysis of fingernail" ; a owl:Class ; rdfs:label "Onycholysis of fingernails" ; rdfs:subClassOf obo:HP_0001231, obo:HP_0001806 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001453 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0009565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040040 obo:IAO_0000115 "Painless and spontaneous separation of a toenail from the nail bed." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022476" ; oboInOwl:hasExactSynonym "Detachment of toenails", "Onycholysis of toenails" ; a owl:Class ; rdfs:label "Toenail onycholysis" ; rdfs:subClassOf obo:HP_0001806, obo:HP_0008388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001453 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040042 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022475" ; oboInOwl:hasExactSynonym "Absent eccrine sweat glands" ; a owl:Class ; rdfs:label "Aplasia of the eccrine sweat glands" ; rdfs:subClassOf obo:HP_0007592, obo:HP_0011136 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040043 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022474" ; oboInOwl:hasExactSynonym "Underdeveloped major sweat glands" ; a owl:Class ; rdfs:label "Hypoplasia of the eccrine sweat glands" ; rdfs:subClassOf obo:HP_0007387, obo:HP_0007592 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040044 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022473" ; oboInOwl:hasExactSynonym "Underdeveloped diaphragm" ; a owl:Class ; rdfs:label "Hypoplasia of the diaphragm" ; rdfs:subClassOf obo:HP_0010315 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040045 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022472" ; oboInOwl:hasExactSynonym "Abnormality of the hemidiaphragms" ; a owl:Class ; rdfs:label "Abnormal hemidiaphragm morphology" ; rdfs:subClassOf obo:HP_0000775 . obo:HP_0040046 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022471" ; oboInOwl:hasExactSynonym "Abnormality of the left hemidiaphragm" ; a owl:Class ; rdfs:label "Abnormal left hemidiaphragm morphology" ; rdfs:subClassOf obo:HP_0040045 . obo:HP_0040047 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022470" ; oboInOwl:hasExactSynonym "Abnormality of the right hemidiaphragm" ; a owl:Class ; rdfs:label "Abnormal right hemidiaphragm morphology" ; rdfs:subClassOf obo:HP_0040045 . obo:HP_0040048 obo:IAO_0100001 "HP:0009112" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Aplasia of the left hemidiaphragm" ; owl:deprecated true . obo:HP_0040049 obo:IAO_0000115 "Thickening of the retina that takes place due to accumulation of fluid in the macula as a nonspecific response to blood-retinal barrier breakdown. Macular edema is a common pathological response to a wide variety of ocular insults, most commonly after intraocular (e.g. cataract) surgery or in association with retinal vascular (e.g. diabetic eye disease, retinal vein occlusion) or inflammatory (e.g. uveitis) disease." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D008269", "SNOMEDCT_US:37231002", "UMLS:C0271051" ; oboInOwl:hasExactSynonym "Macular oedema" ; a owl:Class ; rdfs:label "Macular edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0030498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000053 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040050 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022468" ; oboInOwl:hasExactSynonym "Hypotrichosis of upper eyelashes", "Partial absence of upper eyelashes", "Sparse upper eyelashes" ; a owl:Class ; rdfs:label "Sparse upper eyelashes" ; rdfs:subClassOf obo:HP_0000653, obo:HP_0040051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040051 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022467" ; oboInOwl:hasExactSynonym "Abnormality of upper eyelashes" ; a owl:Class ; rdfs:label "Abnormality of upper eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0019254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040052 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022466" ; oboInOwl:hasExactSynonym "Abnormality of lower eyelashes" ; a owl:Class ; rdfs:label "Abnormality of lower eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0019255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040053 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022465" ; oboInOwl:hasExactSynonym "Ciliary trichomegaly of lower eyelashes", "Increased length of lower eyelashes", "Long lower eyelashes" ; a owl:Class ; rdfs:label "Long lower eyelashes" ; rdfs:subClassOf obo:HP_0000527, obo:HP_0040052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040054 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022464" ; oboInOwl:hasExactSynonym "Decreased length of upper eyelashes", "Short upper eyelashes" ; a owl:Class ; rdfs:label "Short upper eyelashes" ; rdfs:subClassOf obo:HP_0010764, obo:HP_0040051 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040055 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022463" ; oboInOwl:hasExactSynonym "Decreased length of lower eyelashes", "Short lower eyelashes" ; a owl:Class ; rdfs:label "Short lower eyelashes" ; rdfs:subClassOf obo:HP_0010764, obo:HP_0040052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040056 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022462", "UMLS:C4280255", "UMLS:C4280294" ; oboInOwl:hasExactSynonym "Absent upper eyelashes", "Atrichia of upper eyelashes", "Failure of development of upper eyelashes" ; oboInOwl:hasNarrowSynonym "Agenesis of upper eyelashes", "Aplasia of upper eyelashes" ; a owl:Class ; rdfs:label "Absent upper eyelashes" ; rdfs:subClassOf obo:HP_0000561 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0019254 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040057 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021858" ; oboInOwl:hasExactSynonym "Abnormality of nasal hair", "Abnormality of nose hair" ; a owl:Class ; rdfs:label "Abnormality of nasal hair" ; rdfs:subClassOf obo:HP_0000366 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040059 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022461" ; a owl:Class ; rdfs:label "Calcification of ribs" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040061 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022460" ; a owl:Class ; rdfs:label "Osteosclerosis of the radius" ; rdfs:subClassOf obo:HP_0002818, obo:HP_0003967 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040062 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1968813" ; a owl:Class ; rdfs:label "Slender radius" ; rdfs:subClassOf obo:HP_0003100, obo:HP_0003969, obo:HP_0045008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002212 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040063 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022459" ; oboInOwl:hasExactSynonym "Decreased fat tissue" ; a owl:Class ; rdfs:label "Decreased adipose tissue" ; rdfs:subClassOf obo:HP_0009124 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001013 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040064 dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:445144002", "UMLS:C0239337", "UMLS:C4073131" ; oboInOwl:hasExactSynonym "Abnormal limbs", "Abnormality of limbs", "Limb anomaly" ; oboInOwl:hasRelatedSynonym "Dysmelia" ; a owl:Class ; rdfs:label "Abnormality of limbs" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002101 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040065 obo:IAO_0100001 "HP:0040070" ; a owl:Class ; rdfs:label "obsolete Abnormal morphology of bones of the upper limbs" ; owl:deprecated true . obo:HP_0040066 obo:IAO_0100001 "HP:0040069" ; a owl:Class ; rdfs:label "obsolete Abnormal morphology of bones of the lower limbs" ; owl:deprecated true . obo:HP_0040068 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022456" ; oboInOwl:hasExactSynonym "Abnormality of limb bone" ; a owl:Class ; rdfs:label "Abnormality of limb bone" ; rdfs:subClassOf obo:HP_0000924, obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002428 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040069 dcterms:creator ; oboInOwl:hasAlternativeId "HP:0040066" ; oboInOwl:hasDbXref "UMLS:C4022455", "UMLS:C4022457" ; oboInOwl:hasExactSynonym "Abnormal morphology of bones of the lower limbs", "Abnormal shape of bones of the lower limbs", "Abnormality of lower limb bone" ; a owl:Class ; rdfs:label "Abnormal lower limb bone morphology" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010742 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040070 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022454", "UMLS:C4022458" ; oboInOwl:hasExactSynonym "Abnormal morphology of bones of the upper limbs", "Abnormal shape of bones of the upper limbs", "Abnormality of upper limb bone" ; a owl:Class ; rdfs:label "Abnormal upper limb bone morphology" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0002817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010741 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040071 obo:IAO_0000115 "Any structural anomaly of the ulna, a bone of the forearm the extends from the elbow to the little finger." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0002997" ; oboInOwl:hasDbXref "UMLS:C4022453" ; a owl:Class ; rdfs:label "Abnormal morphology of ulna" ; rdfs:subClassOf obo:HP_0011314, obo:HP_0040072 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040072 dcterms:creator ; oboInOwl:hasAlternativeId "HP:0040073" ; oboInOwl:hasDbXref "UMLS:C4022452" ; oboInOwl:hasExactSynonym "Abnormality of forearm bone" ; a owl:Class ; rdfs:label "Abnormal forearm bone morphology" ; rdfs:subClassOf obo:HP_0002973, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040073 obo:IAO_0100001 "HP:0040072" ; dcterms:creator ; a owl:Class ; rdfs:label "Obsolete Abnormal forearm bone morphology" ; owl:deprecated true . obo:HP_0040075 dcterms:creator ; oboInOwl:hasDbXref "MSH:D007018", "SNOMEDCT_US:74728003", "UMLS:C0020635" ; a owl:Class ; rdfs:label "Hypopituitarism" ; rdfs:subClassOf obo:HP_0011747 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0046903 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040077 obo:IAO_0100001 "HP:0004363" ; a owl:Class ; rdfs:label "obsolete Abnormal concentration of calcium in blood" ; owl:deprecated true . obo:HP_0040078 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1837496" ; a owl:Class ; rdfs:label "Axonal degeneration" ; rdfs:subClassOf obo:HP_0000764 . obo:HP_0040079 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1856765" ; oboInOwl:hasExactSynonym "Irregular teeth" ; a owl:Class ; rdfs:label "Irregular dentition" ; rdfs:subClassOf obo:HP_0006482 . obo:HP_0040080 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1857055" ; a owl:Class ; rdfs:label "Anteverted ears" ; rdfs:subClassOf obo:HP_0000357 . obo:HP_0040081 obo:IAO_0000115 "Any deviation from the normal circulating creatine kinase concentration." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022449" ; oboInOwl:hasExactSynonym "Abnormal circulating CK concentration", "Abnormal circulating CPK concentration", "Abnormal circulation phospho-CK concentration", "Abnormal levels of creatine kinase in blood" ; a owl:Class ; rdfs:label "Abnormal circulating creatine kinase concentration" ; rdfs:subClassOf obo:HP_0011021 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0002185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040082 obo:IAO_0000115 "A conspicuously happy disposition with frequent smiling and laughing that may be context-inappropriate or unrelated to context." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1856115" ; oboInOwl:hasExactSynonym "Happy demeanor", "Happy demeanour" ; a owl:Class ; rdfs:label "Happy demeanor" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0040083 obo:IAO_0000115 "Toe walking is a pattern of walking in which a person walks on balls of his or her feet, with no contact between the heels and ground. Toe-walking is common in children who are learning to walk, but most children outgrow it around the age of two years. This term refers to the persistance of toe-walking beyond the usual age." ; obo:IAO_0100001 "HP:0030051" ; a owl:Class ; rdfs:label "obsolete Toe walking" ; owl:deprecated true . obo:HP_0040084 obo:IAO_0000115 "A deviation from the normal concentration of renin in the blood, a central hormone in the control of blood pressure and various other physiological functions." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021038" ; oboInOwl:hasExactSynonym "Abnormal circulating renin", "Abnormal plasma renin" ; a owl:Class ; rdfs:label "Abnormal circulating renin" ; rdfs:subClassOf obo:HP_0000847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000013883 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040085 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C0857898" ; oboInOwl:hasExactSynonym "Abnormal circulating aldosterone", "Abnormal plasma aldosterone" ; a owl:Class ; rdfs:label "Abnormal circulating aldosterone" ; rdfs:subClassOf obo:HP_0000847 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040086 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022448" ; oboInOwl:hasExactSynonym "Abnormal prolactin level" ; a owl:Class ; rdfs:label "Abnormal prolactin level" ; rdfs:subClassOf obo:HP_0000830 . obo:HP_0040087 obo:IAO_0000115 "Any deviation from the normal concentration of folate in the blood circulation." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021037" ; oboInOwl:hasExactSynonym "Abnormal serum folate", "Abnormality of folate in blood" ; a owl:Class ; rdfs:comment "Folate is an essential water-soluble vitamin (vitamin B9) that is found in green leafy vegetables, cereals, legumes, and fruit. As a major methyl group donor, it plays an important role in one-carbon metabolism and is involved in DNA, RNA, and protein synthesis, in addition to its significant role in energy production and normal cell division. Low blood folate concentration is associated with an increased risk for neural tube defects during pregnancy." ; rdfs:label "Abnormal blood folate concentration" ; rdfs:subClassOf obo:HP_0012335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040088 obo:IAO_0000115 "Any abnormality in the total number of lymphocytes in the blood." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:165534000", "UMLS:C0580550" ; oboInOwl:hasExactSynonym "Abnormal lymphocyte count", "Abnormal lymphocyte counts", "Abnormal number of lymphocytes", "Abnormal numbers of lymphocytes", "Abnormality of lymphocyte number" ; a owl:Class ; rdfs:label "Abnormal lymphocyte count" ; rdfs:subClassOf obo:HP_0004332, obo:HP_0011893 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000542 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040089 obo:IAO_0000115 "Any deviation from the normal overall count of natural killer (NK) cells in the circulation or a deviation from the normal distribution of NK cell subtypes." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021036" ; oboInOwl:hasExactSynonym "Abnormal NK cell count", "Abnormal number of natural killer cells", "Abnormality of natural killer cell count" ; a owl:Class ; rdfs:comment "In human peripheral blood, five NK cell subpopulations can be defined on the basis of the relative expression of the markers CD16 and CD56: (1) CD56bright CD16- (50-70% of CD56bright), (2) CD56bright CD16dim (30-50% of CD56bright), (3) CD56dim CD16-, (4) CD56dim CD16bright, and (5) CD56- CD16bright. In healthy individuals, populations (3) and (5) are numerically in the minority." ; rdfs:label "Abnormal natural killer cell count" ; rdfs:subClassOf obo:HP_0012176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040090 obo:IAO_0000115 "An abnormality of the tympanic membrane" ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022447" ; oboInOwl:hasExactSynonym "Abnormality of the eardrum" ; a owl:Class ; rdfs:comment "The tympanic membrane is considered to be the border of middle and outer ear." ; rdfs:label "Abnormality of the tympanic membrane" ; rdfs:subClassOf obo:HP_0000356, obo:HP_0000370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002364 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040091 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022446" ; oboInOwl:hasExactSynonym "Asymmetry of the size of ears" ; a owl:Class ; rdfs:label "Asymmetry of the size of ears" ; rdfs:subClassOf obo:HP_0010722 . obo:HP_0040092 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022445" ; oboInOwl:hasExactSynonym "Asymmetry of the shape of the ears" ; a owl:Class ; rdfs:label "Asymmetry of the shape of the ears" ; rdfs:subClassOf obo:HP_0010722 . obo:HP_0040093 dcterms:creator ; oboInOwl:hasBroadSynonym "Uneven ears" ; oboInOwl:hasDbXref "UMLS:C4022444" ; a owl:Class ; rdfs:label "Asymmetry of the position of the ears" ; rdfs:subClassOf obo:HP_0010722 . obo:HP_0040095 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the outer ear." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4022443" ; oboInOwl:hasExactSynonym "Outer ear tumor", "Outer ear tumour" ; a owl:Class ; rdfs:label "Neoplasm of the outer ear" ; rdfs:subClassOf obo:HP_0000356, obo:HP_0012780 . obo:HP_0040096 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the inner ear." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C1512779" ; oboInOwl:hasExactSynonym "Inner ear tumor", "Inner ear tumour" ; a owl:Class ; rdfs:label "Neoplasm of the inner ear" ; rdfs:subClassOf obo:HP_0000359, obo:HP_0012780 . obo:HP_0040097 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the ceruminal gland." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:403945001", "SNOMEDCT_US:52707009", "UMLS:C0334352" ; oboInOwl:hasExactSynonym "Adenoma of the ceruminous gland", "Ceruminoma", "Ceruminous adenoma" ; a owl:Class ; rdfs:label "Neoplasm of the ceruminal gland" ; rdfs:subClassOf obo:HP_0040095 . obo:HP_0040098 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022442" ; a owl:Class ; rdfs:label "Basalioma of the outer ear" ; rdfs:subClassOf obo:HP_0002671, obo:HP_0040095 . obo:HP_0040099 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022441" ; a owl:Class ; rdfs:label "Abnormality of the round window" ; rdfs:subClassOf obo:HP_0000359, obo:HP_0000370 . obo:HP_0040100 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021035" ; oboInOwl:hasExactSynonym "Abnormality of the oval window" ; a owl:Class ; rdfs:label "Abnormality of the vestibular window" ; rdfs:subClassOf obo:HP_0000359, obo:HP_0000370 . obo:HP_0040101 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022440" ; a owl:Class ; rdfs:label "Cutaneous atresia of the external auditory canal" ; rdfs:subClassOf obo:HP_0000413 . obo:HP_0040102 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022439" ; a owl:Class ; rdfs:label "Osseous atresia of the external auditory canal" ; rdfs:subClassOf obo:HP_0000413 . obo:HP_0040103 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022438" ; a owl:Class ; rdfs:label "Cutaneous stenosis of the external auditory canal" ; rdfs:subClassOf obo:HP_0000402 . obo:HP_0040104 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022437" ; a owl:Class ; rdfs:label "Osseous stenosis of the external auditory canal" ; rdfs:subClassOf obo:HP_0000402 . obo:HP_0040106 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021034" ; oboInOwl:hasExactSynonym "Morphological abnormality of the horizontal semicircular canal" ; a owl:Class ; rdfs:label "Morphological abnormality of the lateral semicircular canal" ; rdfs:subClassOf obo:HP_0011380 . obo:HP_0040107 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022436" ; a owl:Class ; rdfs:label "Morphological abnormality of the posterior semicircular canal" ; rdfs:subClassOf obo:HP_0011380 . obo:HP_0040108 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022435" ; a owl:Class ; rdfs:label "Morphological abnormality of the anterior semicircular canal" ; rdfs:subClassOf obo:HP_0011380 . obo:HP_0040109 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022434" ; a owl:Class ; rdfs:label "Morphological abnormality of the utricle" ; rdfs:subClassOf obo:HP_0011380 . obo:HP_0040110 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022433" ; a owl:Class ; rdfs:label "Morphological abnormality of the saccule" ; rdfs:subClassOf obo:HP_0011380 . obo:HP_0040111 obo:IAO_0100001 "HP:0000377" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Bilateral external ear deformity" ; owl:deprecated true . obo:HP_0040112 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022431" ; a owl:Class ; rdfs:label "Abnormal number of tubercles" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0040113 dcterms:creator ; oboInOwl:hasDbXref "MSH:D011304", "SNOMEDCT_US:49526009", "UMLS:C0033074" ; oboInOwl:hasExactSynonym "Presbycusis" ; a owl:Class ; rdfs:label "Old-aged sensorineural hearing impairment" ; rdfs:subClassOf obo:HP_0000407 . obo:HP_0040114 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022430" ; a owl:Class ; rdfs:label "Absence of the reflex of the tensor tympani muscle" ; rdfs:subClassOf obo:HP_0040120 . obo:HP_0040115 obo:IAO_0000115 "A structural anomaly of the Eustachian tube (ET). The ET is a biomechanical valve between the nasopharynx and the middle ear. Physiologically, it controls the passive adaptation of the middle ear air pressure to the ambient air pressure primarily via direct muscular actions of the soft palate. In the closed state it protects the middle ear. Inadequate function of the ET causes middle ear ventilation disorders." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0040124" ; oboInOwl:hasDbXref "SNOMEDCT_US:204250005", "UMLS:C0262475" ; oboInOwl:hasExactSynonym "Abnormality of the Eustachian tube" ; a owl:Class ; rdfs:label "Abnormal Eustachian tube morphology" ; rdfs:subClassOf obo:HP_0000370 . obo:HP_0040116 dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:75231006", "UMLS:C0266616" ; oboInOwl:hasExactSynonym "Absent eustachian tube" ; a owl:Class ; rdfs:label "Aplasia of the Eustachian tube" ; rdfs:subClassOf obo:HP_0040115 . obo:HP_0040117 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1388953" ; a owl:Class ; rdfs:label "Atresia of the Eustachian tube" ; rdfs:subClassOf obo:HP_0040115 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002393 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040118 dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:80101003", "UMLS:C0271469" ; a owl:Class ; rdfs:label "Stenosis of the Eustachian tube" ; rdfs:subClassOf obo:HP_0040115 . obo:HP_0040119 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022428" ; a owl:Class ; rdfs:label "Unilateral conductive hearing impairment" ; rdfs:subClassOf obo:HP_0000405 . obo:HP_0040120 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022427" ; a owl:Class ; rdfs:label "Abnormality of the reflex of the tensor tympani muscle" ; rdfs:subClassOf obo:HP_0004454 . obo:HP_0040121 obo:IAO_0000115 "An abnormality in the reflexive contraction of the middle-ear muscles in response to sound stimulation." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022426" ; oboInOwl:hasExactSynonym "Abnormal auditory reflex", "Abnormal middle-ear-muscles (MEM) reflex", "Abnormality of stapedial reflex" ; a owl:Class ; rdfs:label "Abnormality of the acoustic reflex" ; rdfs:subClassOf obo:HP_0004454 . obo:HP_0040122 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022425" ; a owl:Class ; rdfs:label "Impairment of the the acoustic reflex" ; rdfs:subClassOf obo:HP_0040121 . obo:HP_0040123 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022424" ; a owl:Class ; rdfs:label "Impairment of the reflex of the tensor tympani muscle" ; rdfs:subClassOf obo:HP_0040120 . obo:HP_0040124 obo:IAO_0100001 "HP:0040115" ; a owl:Class ; rdfs:label "obsolete Patent tuba eustachii" ; owl:deprecated true . obo:HP_0040126 obo:IAO_0000115 "A deviation from the normal concentration of cobalamin (vitamin B12) in the blood. Vitamin B12 is one of the eight B vitamins." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021032" ; oboInOwl:hasExactSynonym "Abnormal serum cobalamin level" ; a owl:Class ; rdfs:label "Abnormal vitamin B12 level" ; rdfs:subClassOf obo:HP_0004341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_30411 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040127 obo:IAO_0000115 "An abnormality of the composition of sweat or the levels of its components." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022423" ; a owl:Class ; rdfs:label "Abnormal sweat homeostasis" ; rdfs:subClassOf obo:HP_0012337 . obo:HP_0040128 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022422" ; a owl:Class ; rdfs:label "Abnormal sweat electrolytes" ; rdfs:subClassOf obo:HP_0040127 . obo:HP_0040129 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1866772" ; oboInOwl:hasExactSynonym "Abnormal nerve conduction", "Abnormal nerve conduction velocities", "Nerve conduction abnormalities" ; a owl:Class ; rdfs:label "Abnormal nerve conduction velocity" ; rdfs:subClassOf obo:HP_0003134 . obo:HP_0040130 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C0235760" ; a owl:Class ; rdfs:label "Abnormal serum iron concentration" ; rdfs:subClassOf obo:HP_0011031 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040131 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021031" ; a owl:Class ; rdfs:label "Abnormal motor nerve conduction velocity" ; rdfs:subClassOf obo:HP_0040129 . obo:HP_0040132 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022421" ; a owl:Class ; rdfs:label "Abnormal sensory nerve conduction velocity" ; rdfs:subClassOf obo:HP_0040129 . obo:HP_0040133 obo:IAO_0000115 "A deviation from the normal circulating concentration of ferritin. Ferritin concentration can be measured in serum or plasma." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C0853228" ; oboInOwl:hasExactSynonym "Abnormal plasma ferritin", "Abnormal serum ferritin" ; a owl:Class ; rdfs:comment "Ferritin is an iron storage protein present in all cells of the organism. A small amount is found in plasma and serum, which is a reflection of iron stores in healthy individuals. A low serum ferritin concentration is usually regarded as an indicator of iron depletion, although the interpretation of normal or high serum ferritin values is challenging in the presence of acute or chronic inflammatory processes, as ferritin is increased in iron overload states and inflammation." ; rdfs:label "Abnormal circulating ferritin concentration" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0070288 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040134 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022420" ; oboInOwl:hasExactSynonym "Abnormal liver iron concentration", "Abnormal liver iron level" ; a owl:Class ; rdfs:label "Abnormal hepatic iron concentration" ; rdfs:subClassOf obo:HP_0034644, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040135 obo:IAO_0000115 "Any abnormality in the serum transferrin saturation, which is calculated by dividing the serum iron level by total iron-binding capacity." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022419" ; a owl:Class ; rdfs:label "Abnormal transferrin saturation" ; rdfs:subClassOf obo:HP_0011031 . obo:HP_0040137 obo:IAO_0000115 "A type of acne in which open and closed comedones comprise the majority of the lesions, with substantially fewer papules and pustules." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022418" ; oboInOwl:hasRelatedSynonym "Comedogenic acne" ; a owl:Class ; rdfs:label "Comedonal acne" ; rdfs:subClassOf obo:HP_0001061 . obo:HP_0040138 obo:IAO_0000115 "Multiple subcutaneous non-fragile and skin-coloured papules characterized by interstitial infiltrate of spindle and epithelioid histiocytes, and mucin. There are well circumscribed aggregates of epithelioid histiocytes and mucin in the upper and middle dermis,with the histiocytes arranged between collagen bundles and separated from the epidermis by a Grenz zone." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:87412005", "UMLS:C0334126" ; oboInOwl:hasExactSynonym "Histiocytosis, mucinous" ; a owl:Class ; rdfs:label "Mucinous histiocytosis" ; rdfs:subClassOf obo:HP_0100727 . obo:HP_0040139 obo:IAO_0000115 "Yellow nodules of lipoid material are deposited in the skin and mucosae. This gives rise to granulomatous reactions." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:189099001", "SNOMEDCT_US:36279001", "SNOMEDCT_US:416439000", "UMLS:C1704214" ; a owl:Class ; rdfs:comment "Usually caused by a faulty lipid metabolism" ; rdfs:label "Lipogranulomatosis" ; rdfs:subClassOf obo:HP_0002955, obo:HP_0004356 . obo:HP_0040140 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022417" ; a owl:Class ; rdfs:label "Degeneration of the striatum" ; rdfs:subClassOf obo:HP_0002180, obo:HP_0010994 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040141 dcterms:creator ; oboInOwl:hasDbXref "MSH:D000071057", "UMLS:C0686347" ; a owl:Class ; rdfs:comment "the involuntary movements are tardive, meaning they have a slow or belated onset" ; rdfs:label "Tardive dyskinesia" ; rdfs:subClassOf obo:HP_0100660 . obo:HP_0040142 obo:IAO_0000115 "Decreased level of the reaction 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:C535322", "SNOMEDCT_US:26132002", "UMLS:C0268525" ; oboInOwl:hasExactSynonym "5-oxoprolinase deficiency" ; a owl:Class ; rdfs:label "Reduced 5-oxoprolinase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_O14841 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040143 obo:IAO_0000115 "Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process. With orthotopic os odontoideum, the ossicle moves with the anterior arch of the atlas, while the dystopic type consists of an ossicle near the basion, or one that is fused with the clivus" ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C3552843" ; a owl:Class ; rdfs:label "Dystopic os odontoideum" ; rdfs:subClassOf obo:HP_0005667 . obo:HP_0040144 obo:IAO_0000115 "An increase in the level of L-2-hydroxyglutaric acid in the urine." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:237961001", "UMLS:C1855995" ; a owl:Class ; rdfs:label "L-2-hydroxyglutaric aciduria" ; rdfs:subClassOf obo:HP_0032278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_32797 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040145 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022416" ; a owl:Class ; rdfs:label "Dicarboxylic acidemia" ; rdfs:subClassOf obo:HP_0010995, obo:HP_0032368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_35692 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040146 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022415" ; a owl:Class ; rdfs:label "D-2-hydroxyglutaric acidemia" ; rdfs:subClassOf obo:HP_0040145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_32796 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040147 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C3888081" ; a owl:Class ; rdfs:label "L-2-hydroxyglutaric acidemia" ; rdfs:subClassOf obo:HP_0040145 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CHEBI_32797 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040148 obo:IAO_0000115 "Cortical myoclonus mainly affects the distal upper limbs and face, which reflects the largest cortical representations of these body areas. It is often focal, but may be multifocal, bilateral or generalized, as a consequence of intracortical and transcallosal spreading of abnormal activity. It typically occurs on voluntary action and may affect speech and gait. Cortical myoclonic jerks are stimulus sensitive, typically to touch, but sensitivity to visual stimuli is also described. Most patients with cortical myoclonus have both positive myoclonus and NM, occurring either independently or together as a complex of the two kinds of myoclonus. If cortical myoclonus is prolonged and lasts for hours, days or weeks, it is called epilepsia partials continua and is considered to be a rare form of focal epileptic status. Focal cortical myoclonus almost always points to an underlining lesion of the sensori-motor cortex, which produces hyperexcitability (e.g. vascular, inflammatory or neoplastic)." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:698835006", "UMLS:C3698239" ; a owl:Class ; rdfs:label "Cortical myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0040149 obo:IAO_0000115 "The presence of woolly hair on the scalp. The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." ; dcterms:creator ; oboInOwl:hasBroadSynonym "Nappy scalp hair texture" ; oboInOwl:hasDbXref "UMLS:C4015203", "UMLS:C4280291", "UMLS:C4280292", "UMLS:C4280293" ; oboInOwl:hasExactSynonym "Wooly scalp hair" ; oboInOwl:hasRelatedSynonym "Afro-textured scalp hair", "Kinky scalp hair texture" ; a owl:Class ; rdfs:label "Woolly scalp hair" ; rdfs:subClassOf obo:HP_0002224 . obo:HP_0040150 dcterms:creator ; oboInOwl:hasDbXref "MSH:C565051", "UMLS:C1851582" ; a owl:Class ; rdfs:label "Epiblepharon of upper lid" ; rdfs:subClassOf obo:HP_0011225 . obo:HP_0040151 dcterms:creator ; oboInOwl:hasDbXref "MSH:C565051", "UMLS:C1851583" ; a owl:Class ; rdfs:label "Epiblepharon of lower lid" ; rdfs:subClassOf obo:HP_0011225 . obo:HP_0040154 obo:IAO_0000115 "A chronic skin condition involving the inflammation of the apocrine sweat glands, forming pimple-like bumps known as abscesses." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D017497", "SNOMEDCT_US:59393003", "UMLS:C0162836" ; oboInOwl:hasExactSynonym "Hidradenitis suppurativa", "Pyoderma fistulans significa", "Smoker's boils", "Verneuil's disease" ; a owl:Class ; rdfs:label "Acne inversa" ; rdfs:subClassOf obo:HP_0001061 . obo:HP_0040155 obo:IAO_0000115 "An increased amount of 3-hydroxybutyric acid in the urine." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022414" ; a owl:Class ; rdfs:label "Elevated urinary 3-hydroxybutyric acid" ; rdfs:subClassOf obo:HP_0033303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_20067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040156 obo:IAO_0000115 "An increased amount of carboxylic acid in the urine." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022413" ; a owl:Class ; rdfs:label "Elevated urinary carboxylic acid" ; rdfs:subClassOf obo:HP_0001992, obo:HP_0031980 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33575 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040157 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022412" ; a owl:Class ; rdfs:label "Abnormal intermamillary distance" ; rdfs:subClassOf obo:HP_0004404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040158 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022411" ; a owl:Class ; rdfs:label "Short intermamillary distance" ; rdfs:subClassOf obo:HP_0040157 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0013771 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040159 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022410" ; oboInOwl:hasExactSynonym "Abnormal spaced incisors", "Abnormality of spacing of front teeth", "Abnormality of spacing of incisors" ; a owl:Class ; rdfs:label "Abnormal spaced incisors" ; rdfs:subClassOf obo:HP_0011062 . obo:HP_0040160 oboInOwl:hasAlternativeId "HP:0005744" ; oboInOwl:hasDbXref "MSH:D010024", "SNOMEDCT_US:64859006", "UMLS:C0029456", "UMLS:C3805887" ; oboInOwl:hasExactSynonym "Generalised osteoporosis" ; oboInOwl:hasRelatedSynonym "Generalised osteoporosis with pathologic fractures", "Generalized osteoporosis with pathologic fractures" ; a owl:Class ; rdfs:label "Generalized osteoporosis" ; rdfs:subClassOf obo:HP_0000939 . obo:HP_0040161 oboInOwl:hasDbXref "UMLS:C1398367" ; oboInOwl:hasExactSynonym "Localised osteoporosis" ; a owl:Class ; rdfs:label "Localized osteoporosis" ; rdfs:subClassOf obo:HP_0000939 . obo:HP_0040162 obo:IAO_0000115 "Formation of an anuclear keratin layer" ; oboInOwl:hasDbXref "SNOMEDCT_US:708474007", "UMLS:C1843359" ; a owl:Class ; rdfs:label "Orthokeratosis" ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0040163 oboInOwl:hasDbXref "UMLS:C4073132" ; oboInOwl:hasExactSynonym "Abnormal shape of pelvis bone" ; a owl:Class ; rdfs:label "Abnormal pelvis bone morphology" ; rdfs:subClassOf obo:HP_0002644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007830 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040164 obo:IAO_0000115 "Fatty tumors on the eyelids." ; oboInOwl:hasDbXref "UMLS:C4073133" ; oboInOwl:hasExactSynonym "Fatty tumors on the eyelids", "Fatty tumours on the eyelids" ; a owl:Class ; rdfs:comment "Eyelid lipomas" ; rdfs:label "Lipomas of eyelids" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0012032 . obo:HP_0040165 obo:IAO_0000115 "Inflammation of the periosteum" ; oboInOwl:hasDbXref "MSH:D010522", "SNOMEDCT_US:41910004", "UMLS:C0031111" ; oboInOwl:hasExactSynonym "Periostalgia" ; a owl:Class ; rdfs:label "Periostitis" ; rdfs:subClassOf obo:HP_0030313 ; owl:equivalentClass _:genid95540 . obo:HP_0040166 obo:IAO_0100001 "HP:0030313" ; a owl:Class ; rdfs:label "obsolete Abnormality of the periosteum" ; owl:deprecated true . obo:HP_0040167 oboInOwl:hasDbXref "SNOMEDCT_US:240533004", "UMLS:C0343643" ; oboInOwl:hasExactSynonym "Facial verruca", "Facial wart" ; a owl:Class ; rdfs:comment "A very specific feature of Costello Syndrome" ; rdfs:label "Facial papilloma" ; rdfs:subClassOf obo:HP_0011799, obo:HP_0012740 . obo:HP_0040168 obo:IAO_0100001 "HP:0007359" ; a owl:Class ; rdfs:label "obsolete Focal seizures, afebril" ; owl:deprecated true . obo:HP_0040169 oboInOwl:hasDbXref "UMLS:C3554793" ; a owl:Class ; rdfs:label "Loose anagen hair" ; rdfs:subClassOf obo:HP_0040170 . obo:HP_0040170 oboInOwl:hasDbXref "UMLS:C4073136" ; a owl:Class ; rdfs:label "Abnormality of hair growth" ; rdfs:subClassOf obo:HP_0001595 . obo:HP_0040171 dcterms:creator ; oboInOwl:hasAlternativeId "HP:0008230" ; oboInOwl:hasBroadSynonym "Decreased testosterone" ; oboInOwl:hasDbXref "SNOMEDCT_US:131078003", "UMLS:C1295654", "UMLS:C4073137" ; oboInOwl:hasExactSynonym "Decreased serum testosterone level", "Decreased serum testosterone levels", "Low serum testosterone level", "Low serum testosterone levels" ; a owl:Class ; rdfs:label "Decreased serum testosterone concentration" ; rdfs:subClassOf obo:HP_0030087, obo:HP_0030349 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17347 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040172 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073138" ; a owl:Class ; rdfs:label "Abnormality of occipitofrontalis muscle" ; rdfs:subClassOf obo:HP_0003011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010946 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040173 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073139" ; oboInOwl:hasExactSynonym "Abnormality of lingual muscle", "Abnormality of the tongue muscle" ; a owl:Class ; rdfs:label "Abnormality of the tongue muscle" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000378 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040174 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073140" ; oboInOwl:hasExactSynonym "Abnormality of extrinsic lingual muscle" ; a owl:Class ; rdfs:label "Abnormality of extrinsic muscle of tongue" ; rdfs:subClassOf obo:HP_0040173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001575 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040175 obo:IAO_0000115 "Reduced level of platelet-activating factor acetylhydrolase." ; oboInOwl:hasDbXref "MSH:C566640", "UMLS:C3280315" ; a owl:Class ; rdfs:label "Platelet-activating factor acetylhydrolase deficiency" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0040176 obo:IAO_0000115 "Any deviation from the normal concentration of a phospholipid in the blood circulation." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073141" ; oboInOwl:hasExactSynonym "Abnormal level of phospholipids" ; a owl:Class ; rdfs:label "Abnormal circulating phospholipid concentration" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16247 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040177 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073142" ; oboInOwl:hasExactSynonym "Abnormal level of PAF" ; a owl:Class ; rdfs:label "Abnormal level of platelet-activating factor" ; rdfs:subClassOf obo:HP_0040176 . obo:HP_0040178 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073143" ; oboInOwl:hasExactSynonym "Increased level of PAF" ; a owl:Class ; rdfs:label "Increased level of platelet-activating factor" ; rdfs:subClassOf obo:HP_0040177 . obo:HP_0040179 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073144" ; oboInOwl:hasExactSynonym "Decreased level of PAF" ; a owl:Class ; rdfs:label "Decreased level of platelet-activating factor" ; rdfs:subClassOf obo:HP_0040177 . obo:HP_0040180 obo:IAO_0100001 "HP:0032152" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Hyperkeratosis pilaris" ; owl:deprecated true . obo:HP_0040181 obo:IAO_0000115 "Cracking, fissuring, and peeling of the skin of the lips." ; oboInOwl:hasDbXref "MSH:D019557", "SNOMEDCT_US:16459000", "SNOMEDCT_US:238751002", "SNOMEDCT_US:248182008", "SNOMEDCT_US:402294001", "UMLS:C0263449", "UMLS:C0424489" ; oboInOwl:hasExactSynonym "Chapped lip", "Chapped lips", "Cheilitis simplex", "Common cheilitis", "Dry lips" ; oboInOwl:hasRelatedSynonym "Perioral dermatitis" ; a owl:Class ; rdfs:label "Chapped lip" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0040182 obo:IAO_0000115 "Inappropriate sinus tachycardia is a nonparoxysmal tachyarrhythmia characterized by an increased resting heart rate (HR) and/or an exaggerated HR response to minimal exertion or a change in body posture. HR is constantly above the physiological range with no appropriate relation to metabolic or physiological demands." ; oboInOwl:hasDbXref "SNOMEDCT_US:425582007", "UMLS:C1881170" ; a owl:Class ; rdfs:label "Inappropriate sinus tachycardia" ; rdfs:subClassOf obo:HP_0011703 . obo:HP_0040183 oboInOwl:hasDbXref "SNOMEDCT_US:302690004", "UMLS:C2945606" ; oboInOwl:hasExactSynonym "Stool holding", "Stool soiling" ; a owl:Class ; rdfs:label "Encopresis" ; rdfs:subClassOf obo:HP_0002607 . obo:HP_0040184 oboInOwl:hasDbXref "MSH:D006472", "SNOMEDCT_US:22490002", "UMLS:C0029163" ; oboInOwl:hasExactSynonym "Oral bleeding", "Oral haemorrhage", "Oral hemorrhage" ; a owl:Class ; rdfs:label "Oral bleeding" ; rdfs:subClassOf obo:HP_0031815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000167 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040185 oboInOwl:hasDbXref "UMLS:C2751260" ; oboInOwl:hasExactSynonym "Macrothrombozytopenia" ; a owl:Class ; rdfs:label "Macrothrombocytopenia" ; rdfs:subClassOf obo:HP_0001873, obo:HP_0011877 . obo:HP_0040186 obo:IAO_0000115 "A skin rash that is characterized by diffuse cutaneous erythema with areas of skin elevation. It may evolve to vesicles or papules as part of a more severe clinical entity. Different degrees of angioedema with involvement of subcutaneous tissue may also appear." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:247471006", "SNOMEDCT_US:47725002", "UMLS:C0423791" ; a owl:Class ; rdfs:label "Maculopapular exanthema" ; rdfs:subClassOf obo:HP_4000054 . obo:HP_0040187 obo:IAO_0000115 "Systemic inflammatory response to infection in newborn babies." ; oboInOwl:hasDbXref "MSH:D000071074", "SNOMEDCT_US:206376005", "UMLS:C0456103" ; a owl:Class ; rdfs:label "Neonatal sepsis" ; rdfs:subClassOf obo:HP_0100806 . obo:HP_0040188 obo:IAO_0000115 "Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D055034", "SNOMEDCT_US:19579005", "UMLS:C0029429" ; a owl:Class ; rdfs:label "Osteochondrosis" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0100323 . obo:HP_0040189 obo:IAO_0000115 "Refers to the loss of the outer layer of the epidermis in large, scale-like flakes." ; oboInOwl:hasDbXref "SNOMEDCT_US:14411002", "SNOMEDCT_US:271767006", "UMLS:C0237849" ; oboInOwl:hasExactSynonym "Desquamation", "Scaling skin", "Scaly skin", "flaking skin", "peeling skin" ; a owl:Class ; rdfs:label "Scaling skin" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0040190 oboInOwl:hasDbXref "UMLS:C4073146" ; oboInOwl:hasExactSynonym "White scaling skin", "White scaly skin" ; a owl:Class ; rdfs:label "White scaling skin" ; rdfs:subClassOf obo:HP_0040189 . obo:HP_0040191 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C2083352" ; oboInOwl:hasExactSynonym "Atrophy of the rectus femoris muscles" ; a owl:Class ; rdfs:label "Rectus femoris muscle atrophy" ; rdfs:subClassOf obo:HP_0009050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001378 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040192 obo:IAO_0000115 "An endocrine tumor arising from an APUD cell." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D001079", "SNOMEDCT_US:253008000", "SNOMEDCT_US:74926005", "UMLS:C0003650" ; oboInOwl:hasExactSynonym "amine precursor uptake and decarboxylation tumours" ; a owl:Class ; rdfs:label "APUdoma" ; rdfs:subClassOf obo:HP_0100568 . obo:HP_0040193 obo:IAO_0100001 "HP:0030408" ; a owl:Class ; rdfs:label "obsolete Pinealoblastoma" ; owl:deprecated true . obo:HP_0040194 obo:IAO_0000115 "An abnormally increased head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart." ; oboInOwl:hasDbXref "UMLS:C4083076" ; oboInOwl:hasExactSynonym "Increased head circumference" ; a owl:Class ; rdfs:label "Increased head circumference" ; rdfs:subClassOf obo:HP_0000240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040195 obo:IAO_0000115 "An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean." ; oboInOwl:hasDbXref "SNOMEDCT_US:271611007", "UMLS:C0424688" ; oboInOwl:hasExactSynonym "Decreased head circumference" ; a owl:Class ; rdfs:comment "Although HC measures skull size, it typically also reflects overall brain volume and has been described as a widely used proxy of neural growth and brain size. Brain size outside of normal values is an important risk factor for cognitive and motor delay. Microcephaly at birth has been termed primary microcephaly and that acquired after birth is secondary microcephaly." ; rdfs:label "Decreased head circumference" ; rdfs:subClassOf obo:HP_0000240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001899 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040196 obo:IAO_0000115 "Decreased occipito-frontal (head) circumference (OFC). For the microcephaly OFC must be between -3 SD and -2 SD compared to appropriate, age matched, normal standards (i.e. -3 SD <= OFC < -2 SD)." ; oboInOwl:hasDbXref "UMLS:C1836806" ; a owl:Class ; rdfs:label "Mild microcephaly" ; rdfs:subClassOf obo:HP_0040195 . obo:HP_0040197 obo:IAO_0000115 "Encephalomalacia is the softening or loss of brain tissue after cerebral infarction, cerebral ischemia, infection, craniocerebral trauma, or other injury." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D004678", "SNOMEDCT_US:58762006", "UMLS:C0014068" ; oboInOwl:hasExactSynonym "Cerebral softening" ; a owl:Class ; rdfs:label "Encephalomalacia" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0040198 oboInOwl:hasDbXref "MSH:C536915", "UMLS:C3501843" ; oboInOwl:hasExactSynonym "Nonmedullary thyroid carcinoma", "Thyroid cancer, nonmedullary" ; a owl:Class ; rdfs:label "Non-medullary thyroid carcinoma" ; rdfs:subClassOf obo:HP_0002890 . obo:HP_0040199 obo:IAO_0100001 "HP:0011800" ; a owl:Class ; rdfs:label "obsolete Flat midface" ; owl:deprecated true . obo:HP_0040200 obo:IAO_0000115 "The inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073148" ; oboInOwl:hasExactSynonym "Negative chorea" ; a owl:Class ; rdfs:comment "Damage to premotor and prefrontal regions results in motor-intentional disorders that disrupt initiation, maintenance, and termination of volitional movements. Motor impersistence (i.e., failure to maintain movement) more frequently develops following right than left hemisphere lesions." ; rdfs:label "Motor impersistence" ; rdfs:subClassOf obo:HP_0011443 . obo:HP_0040201 obo:IAO_0000115 "A subset of motor impersistence, defined as the inability to perform more than two of the simple voluntary acts simultaneously, such as closing the eyes and protruding the tongue." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073149" ; a owl:Class ; rdfs:label "Simultanapraxia" ; rdfs:subClassOf obo:HP_0040200 . obo:HP_0040202 obo:IAO_0000115 "Abnormal and compulsive consumption of food, liquid, or objects that could have negative consequences for the individual." ; dcterms:contributor , , , , ; oboInOwl:hasDbXref "UMLS:C4073150" ; oboInOwl:hasExactSynonym "Abnormal consumption behaviour" ; a owl:Class ; rdfs:label "Abnormal consumption behavior" ; rdfs:subClassOf obo:HP_5200045 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0001845 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040203 obo:IAO_0000115 "Abnormal concentration of neopterin in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073151" ; oboInOwl:hasExactSynonym "Abnormal CSF neopterin level" ; a owl:Class ; rdfs:label "Abnormal CSF neopterin concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040204 obo:IAO_0000115 "Increased concentration of neopterin in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073152" ; a owl:Class ; rdfs:label "Elevated CSF neopterin level" ; rdfs:subClassOf obo:HP_0040203 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040205 obo:IAO_0000115 "Decreased concentration of neopterin in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073153" ; a owl:Class ; rdfs:label "Decreased CSF neopterin level" ; rdfs:subClassOf obo:HP_0040203 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040206 obo:IAO_0000115 "Any deviation from the normal concentration of neopterin in the blood circulation." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073154" ; a owl:Class ; rdfs:comment "Neopterin can be found to have abnormal level in blood, CSF, or urine." ; rdfs:label "Abnormal circulating neopterin concentration" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25500 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040207 obo:IAO_0000115 "Abnormal concentration of biopterin in the cerebrospinal fluid (CSF)." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073155" ; oboInOwl:hasExactSynonym "Abnormal CSF biopterin level", "Abnormal cerebrospinal fluid biopterin level" ; a owl:Class ; rdfs:label "Abnormal CSF biopterin concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040208 obo:IAO_0000115 "Concentration of biopterin in the cerebrospinal fluid (CSF) above the upper limit of normal." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073156" ; a owl:Class ; rdfs:label "Elevated CSF biopterin level" ; rdfs:subClassOf obo:HP_0040207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040209 obo:IAO_0000115 "Concentration of biopterin in the cerebrospinal fluid (CSF) below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073157" ; oboInOwl:hasExactSynonym "Decreased cerebrospinal fluid biopterin level" ; a owl:Class ; rdfs:label "Decreased CSF biopterin level" ; rdfs:subClassOf obo:HP_0040207 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040210 obo:IAO_0000115 "A deviation from the normal concentration of biopterin in the blood circulation." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073158" ; a owl:Class ; rdfs:label "Abnormal circulating biopterin concentration" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040211 obo:IAO_0000115 "An abnormality of the skin of the palm, that is, the skin of the front of the hand." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073159" ; a owl:Class ; rdfs:label "Abnormal skin morphology of the palm" ; rdfs:subClassOf obo:HP_0011356, obo:HP_0100871 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002097 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008878 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040212 obo:IAO_0000115 "Fixed sarcastic grimace and anxious expression. Caused by spasms of the masseter and other facial muscles." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:64314006", "UMLS:C0343494" ; oboInOwl:hasExactSynonym "Rictus grin" ; a owl:Class ; rdfs:comment "Accompanied by rigidity of neck and trunk muscles and arching of back. Often observed as a sign of tetanus." ; rdfs:label "Risus sardonicus" ; rdfs:subClassOf obo:HP_0005324 . obo:HP_0040213 obo:IAO_0000115 "Hypopnea is referring to breathing that is abnormally shallow." ; oboInOwl:hasDbXref "SNOMEDCT_US:386614005", "UMLS:C0235546" ; oboInOwl:hasExactSynonym "Shallow breathing" ; a owl:Class ; rdfs:comment "Not to be confused with Hypoventilation. Hypopnea is distinct from apnea in which there is no breathing." ; rdfs:label "Hypopnea" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0040214 obo:IAO_0000115 "An abnormal concentration of insulin in the body." ; oboInOwl:hasAlternativeId "HP:0040215" ; oboInOwl:hasDbXref "UMLS:C4073160" ; oboInOwl:hasExactSynonym "Abnormal insulin level" ; a owl:Class ; rdfs:label "Abnormal circulating insulin concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009054 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040215 obo:IAO_0100001 "HP:0040214" ; a owl:Class ; rdfs:label "obsolete Abnormal circulating insulin level" ; owl:deprecated true . obo:HP_0040216 obo:IAO_0000115 "A decreased concentration of insulin in the blood." ; oboInOwl:hasDbXref "UMLS:C2748055" ; a owl:Class ; rdfs:label "Hypoinsulinemia" ; rdfs:subClassOf obo:HP_0040214 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000009054 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040217 obo:IAO_0000115 "An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements." ; oboInOwl:hasDbXref "UMLS:C4073162" ; oboInOwl:hasExactSynonym "Elevated HbA1c", "Elevated glycated haemoglobin", "Elevated glycated hemoglobin", "Elevated glycosylated haemoglobin", "Elevated glycosylated hemoglobin", "Elevated haemoglobin A1c", "Increased HbA1c levels" ; a owl:Class ; rdfs:label "Elevated hemoglobin A1c" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0040218 obo:IAO_0000115 "Less than normal number of natural killer cells, a type of lymphocyte in the innate immune system with an ability to mediate cytotoxicity and produce cytokines after the ligation of a germline-encoded activation receptor." ; oboInOwl:hasDbXref "UMLS:C1855767" ; oboInOwl:hasExactSynonym "Reduced NK cell number", "Reduced natural killer cell number" ; a owl:Class ; rdfs:label "Reduced natural killer cell count" ; rdfs:subClassOf obo:HP_0040089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040219 obo:IAO_0000115 "Lack of natural killer cells, a type of lymphocyte in the innate immune system that contains cytoplasmic granzymes, i.e., small granules with perforin and proteases that allow natural killer cells to form pores in the cell membrane of the target cell through which the granzymes and associated molecules can enter, inducing apoptosis." ; oboInOwl:hasDbXref "UMLS:C4073163" ; oboInOwl:hasExactSynonym "Absent NK cells" ; a owl:Class ; rdfs:label "Absent natural killer cells" ; rdfs:subClassOf obo:HP_0500033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040220 oboInOwl:hasDbXref "UMLS:C4280723" ; a owl:Class ; rdfs:label "Abnormal size of the dental root" ; rdfs:subClassOf obo:HP_0006486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040221 oboInOwl:hasDbXref "UMLS:C4280722" ; a owl:Class ; rdfs:label "Hypoplasia of the dental root" ; rdfs:subClassOf obo:HP_0040220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040222 obo:IAO_0000115 "An increased tendency towards thrombosis in the mother during a pregnancy." ; oboInOwl:hasDbXref "UMLS:C4280721" ; a owl:Class ; rdfs:comment "Maternal thrombophilia has been linked to an increased incidence of placental abruption, as well as other adverse pregnancy outcomes. It is believed that the increased obstetrical risk is mediated through placental vascular dysfunction. Placental thrombosis can then result in subsequent ischemic complications, such as fetal loss, preeclampsia, and fetal growth restriction. Placental abruption has been identified as being part of the spectrum of ischemic placental disease and is postulated to be a chronic disease process (PMID:25401392)." ; rdfs:label "Maternal thrombophilia" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0040223 obo:IAO_0000115 "Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease." ; oboInOwl:hasDbXref "UMLS:C4280720" ; oboInOwl:hasExactSynonym "Intrapulmonary haemorrhage", "Intrapulmonary hemorrhage", "Pulmonary haemorrhage" ; a owl:Class ; rdfs:label "Pulmonary hemorrhage" ; rdfs:subClassOf obo:HP_0002088, obo:HP_0011029 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001561 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040224 obo:IAO_0000115 "Clincial phenotype characterized by delayed bleeding accelerated break down of blood clot (fibrinolysis)" ; oboInOwl:hasDbXref "UMLS:C4280719" ; oboInOwl:hasExactSynonym "Abnormality of the fibrinolytic system" ; a owl:Class ; rdfs:comment "requested and created by members of the BRIDGE consortium" ; rdfs:label "Abnormality of fibrinolysis" ; rdfs:subClassOf obo:HP_0001928 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0042730 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040225 obo:IAO_0000115 "A decrease in high molecular weight von Willebrand factor multimers." ; oboInOwl:hasDbXref "UMLS:C4280718" ; oboInOwl:hasExactSynonym "Decrease in HMW VWF multimers" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium." ; rdfs:label "Decrease in high molecular weight von Willebrand factor Multimers" ; rdfs:subClassOf obo:HP_0030131 . obo:HP_0040226 obo:IAO_0000115 "An abnormality of coagulation related to a decreased concentration of heparin co-factor II" ; oboInOwl:hasDbXref "UMLS:C4280717" ; oboInOwl:hasExactSynonym "Heparin co-factor II deficiency" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium" ; rdfs:label "Decreased level of heparin co-factor II" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040227 obo:IAO_0000115 "Decrease of these levels result in increased inhibition of fibrinolysis and reduced inhibition of coagulation" ; oboInOwl:hasDbXref "UMLS:C4280716" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium" ; rdfs:label "Decreased level of histidine-rich glycoprotein" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040228 obo:IAO_0000115 "A decreased level of Plasminogen" ; oboInOwl:hasDbXref "UMLS:C4280715" ; oboInOwl:hasExactSynonym "Hypoplasminogenemia" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium" ; rdfs:label "Decreased level of plasminogen" ; rdfs:subClassOf obo:HP_0010990, obo:HP_0032312 . obo:HP_0040229 obo:IAO_0000115 "Thrombomodulin is a cofactor in the thrombin induced activation of Protein C. In the case of deficiency there will be less Protein C and tendency to clot" ; oboInOwl:hasDbXref "UMLS:C4255334" ; oboInOwl:hasRelatedSynonym "BDCA-3" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium" ; rdfs:label "Decreased level of thrombomodulin" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040230 obo:IAO_0000115 "The tPA protein catalyzes the conversion of plasiminogen to plasmin, and thus break down of clots. When there is a deficiency there will be an increase of thrombosis" ; oboInOwl:hasDbXref "UMLS:C4280714" ; oboInOwl:hasExactSynonym "Decreased level of tPA" ; a owl:Class ; rdfs:comment "Requested and created by members of the BRIDGE consortium" ; rdfs:label "Decreased level of tissue plasminogen activator" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040231 oboInOwl:hasDbXref "UMLS:C4280713" ; a owl:Class ; rdfs:label "Abnormal onset of bleeding" ; rdfs:subClassOf obo:HP_0001892 . obo:HP_0040232 obo:IAO_0000115 "Abnormal bleeding related to a procedure or trauma which does not start at the time of the initial insult, but after delay by at least 24 hours." ; oboInOwl:hasDbXref "UMLS:C4280712" ; a owl:Class ; rdfs:label "Delayed onset bleeding" ; rdfs:subClassOf obo:HP_0040231 . obo:HP_0040233 obo:IAO_0000115 "Deficiency of factor XIII subunit A, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot." ; oboInOwl:hasDbXref "MSH:C567691", "UMLS:C2750514" ; oboInOwl:hasExactSynonym "Reduced factor XIII, subunit A" ; a owl:Class ; rdfs:comment "Measurement of subunit A or B can be performed by Elisa kits. Adding the more granular term would facilitate mutation analysis as both subunits are encoded by different genes. This is not always performed in the diagnostic workup so 'Reduced factor XIII activity' would sufice. This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Factor XIII subunit A deficiency" ; rdfs:subClassOf obo:HP_0008357 . obo:HP_0040234 obo:IAO_0000115 "Deficiency of factor XIII subunit B, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot." ; oboInOwl:hasDbXref "MSH:C567688", "UMLS:C2750481" ; oboInOwl:hasExactSynonym "Reduced factor XIII, subunit B" ; a owl:Class ; rdfs:comment "Measurement of subunit A or B can be performed by Elisa kits. Adding the more granular term would facilitate mutation analysis as both subunits are encoded by different genes. This is not always performed in the diagnostic workup so 'Reduced factor XIII activity' would sufice. This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Factor XIII subunit B deficiency" ; rdfs:subClassOf obo:HP_0008357 . obo:HP_0040235 obo:IAO_0000115 "The presence of intraceullar inclusion bodies (aggregates of stainable substances, usually proteins) in leukocytes." ; oboInOwl:hasDbXref "UMLS:C4280711" ; oboInOwl:hasExactSynonym "Dohle-like leukocyte inclusion bodies", "Inclusion bodies in leukocytes" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Leukocyte inclusion bodies" ; rdfs:subClassOf obo:HP_0008264 . obo:HP_0040236 obo:IAO_0000115 "Increased degradation of fibrin, associated with clot instability and bleeding" ; oboInOwl:hasDbXref "UMLS:C3805089" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Hyperfibrinolysis" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0040237 obo:IAO_0000115 "Impaired binding of factor VIII to von Willebrand Factor. This is determined using a modified ELISA assay." ; oboInOwl:hasDbXref "UMLS:C4280710" ; oboInOwl:hasExactSynonym "von Willebrand Disease Type II Normandy" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Impaired binding of factor VIII to VWF" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0040238 obo:IAO_0000115 "An impairment of the migration of neutrophils towards chemoattractants as part of the innate immune response" ; oboInOwl:hasDbXref "UMLS:C4280709" ; oboInOwl:hasExactSynonym "Neutrophil migratory defect" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Impaired neutrophil chemotaxis" ; rdfs:subClassOf obo:HP_0005400 . obo:HP_0040239 obo:IAO_0000115 "Increased plasma vitamin K epoxide after vitamin K supplementation is present in VKCFD (vitamin K-dependent clotting factor deficiency) type 2, but not in VKCFD type 1." ; oboInOwl:hasDbXref "UMLS:C4280708" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Increased plasma vitamin K epoxide after vitamin K supplementation" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040240 obo:IAO_0000115 "An increased VWF propeptide to VWF antigen indicates that deficiency of VWF is not due to impaired synthesis but due to rapid clearance. The VWF propeptide is measured by ELISA." ; oboInOwl:hasDbXref "UMLS:C4280707" ; a owl:Class ; rdfs:comment "Some forms of von Willebrand Disease Type I (particularly those previously classified as type IC) and Acquired von Willebrand Disease. This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Increased ratio of VWF propeptide to VWF antigen" ; rdfs:subClassOf obo:HP_0012146 . obo:HP_0040241 obo:IAO_0000115 "Increased platelet agglutination in response to low-dose ristocetin" ; oboInOwl:hasDbXref "UMLS:C4280706" ; a owl:Class ; rdfs:comment "Characteristic of type 2B von Willebrand Disease or platelet-type (pseudo) VWD. (NB: this is not the same as enhanced ristocetin coafactor assay activity) This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Increased RIPA" ; rdfs:subClassOf obo:HP_0030402 . obo:HP_0040242 obo:IAO_0000115 "Bleeding occuring within a muscle" ; oboInOwl:hasDbXref "SNOMEDCT_US:95422003", "UMLS:C0151702" ; oboInOwl:hasExactSynonym "Muscle haemorrhage" ; a owl:Class ; rdfs:label "Muscle hemorrhage" ; rdfs:subClassOf obo:HP_0011029, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_119 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040243 obo:IAO_0000115 "Abnormally increased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored." ; oboInOwl:hasDbXref "UMLS:C4280705" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Prolonged euglobulin clot lysis time" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0040244 obo:IAO_0000115 "Increased time to coagulation in the Russell's viper venom assay" ; oboInOwl:hasDbXref "UMLS:C4280704" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Prolonged Russell's viper venom time" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040245 obo:IAO_0000115 "Reduced activity of alpha-2-antiplasmin. This protein inactivates the protease plasmin that drives fibrinolysis." ; oboInOwl:hasDbXref "UMLS:C4280703" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced alpha-2-antiplasmin activity" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040246 obo:IAO_0000115 "Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation." ; oboInOwl:hasDbXref "UMLS:C4280702" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced antithrombin antigen" ; rdfs:subClassOf obo:HP_0010990 . obo:HP_0040247 obo:IAO_0000115 "Abnormally decreased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored." ; oboInOwl:hasDbXref "UMLS:C4280701" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced euglobulin clot lysis time" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0040248 obo:IAO_0000115 "Reduced activity of plasminogen activator inhibitor 1. This protein down-regulates fibrinolysis in the circulation by inhibiting the two major plasminogen activators: tissue-plasminogen activator and urokinase-plasminogen activator." ; oboInOwl:hasDbXref "UMLS:C4280700" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced plasminogen activator inhibitor 1 activity" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0040249 obo:IAO_0000115 "Reduced level of plasminogen activator inhibitor 1 antigen." ; oboInOwl:hasDbXref "UMLS:C4280699" ; a owl:Class ; rdfs:comment "Added the antigen level as diagnosis with only activity levels is very difficult due to assay problems. Activity levels of control patients also include 0 within the normal limit. This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced plasminogen activator inhibitor 1 antigen" ; rdfs:subClassOf obo:HP_0040224 . obo:HP_0040250 obo:IAO_0000115 "Reduced prothrombin antigen as measured by ELISA assay. Prothrombin is a vitamin K-dependent coagulation factor that is proteolytically cleaved to form thrombin." ; oboInOwl:hasDbXref "UMLS:C4280698" ; a owl:Class ; rdfs:comment "This term has been requested and created by members of the BRIDGE consortium" ; rdfs:label "Reduced prothrombin antigen" ; rdfs:subClassOf obo:HP_0012200 . obo:HP_0040251 obo:IAO_0000115 "A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the hand." ; oboInOwl:hasDbXref "UMLS:C4280697" ; oboInOwl:hasExactSynonym "Hand dimples" ; a owl:Class ; rdfs:comment "Use case: PMC4498842" ; rdfs:label "Hand dimple" ; rdfs:subClassOf obo:HP_0010781 . obo:HP_0040252 oboInOwl:hasDbXref "UMLS:C4280696" ; a owl:Class ; rdfs:label "Abnormal size of the clitoris" ; rdfs:subClassOf obo:HP_0000056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040253 oboInOwl:hasDbXref "UMLS:C4280695" ; a owl:Class ; rdfs:label "Increased size of the clitoris" ; rdfs:subClassOf obo:HP_0040252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040254 oboInOwl:hasDbXref "UMLS:C4280694" ; a owl:Class ; rdfs:label "Decreased size of the clitoris" ; rdfs:subClassOf obo:HP_0040252 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040255 oboInOwl:hasDbXref "UMLS:C4280693" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the clitoris" ; rdfs:subClassOf obo:HP_0000056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040256 obo:IAO_0000115 "Absence or underdevelopment of the nasopharyngeal adenoids." ; oboInOwl:hasDbXref "UMLS:C4280290" ; oboInOwl:hasRelatedSynonym "Adenoids small or absent" ; a owl:Class ; rdfs:label "Aplastic/Hypoplastic nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_3000033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040257 obo:IAO_0000115 "A deviation in the size of nasopharyngeal adenoids." ; oboInOwl:hasDbXref "UMLS:C4280692" ; a owl:Class ; rdfs:label "Abnormal size of nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_3000033 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040258 obo:IAO_0000115 "Underdevelopment of the nasopharyngeal adenoids." ; oboInOwl:hasDbXref "UMLS:C4280691" ; oboInOwl:hasExactSynonym "Underdeveloped nasopharyngeal adenoids" ; a owl:Class ; rdfs:label "Hypoplastic nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_0040256, obo:HP_0040260 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040259 obo:IAO_0000115 "Absence of the nasopharyngeal adenoids as a developmental defect." ; oboInOwl:hasDbXref "UMLS:C4280690" ; a owl:Class ; rdfs:label "Aplastic nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_0040256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040260 obo:IAO_0000115 "An abnormal decrease in the size of nasopharyngeal adenoids." ; oboInOwl:hasDbXref "UMLS:C4280689" ; a owl:Class ; rdfs:label "Decreased size of nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_0040257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040261 obo:IAO_0000115 "An abnormal increase in the size of nasopharyngeal adenoids." ; oboInOwl:hasDbXref "SNOMEDCT_US:111591002", "SNOMEDCT_US:276442006", "UMLS:C0149825", "UMLS:C0455938" ; oboInOwl:hasRelatedSynonym "Adenoid hypertrophy", "Adenoids large" ; a owl:Class ; rdfs:label "Increased size of nasopharyngeal adenoids" ; rdfs:subClassOf obo:HP_0040257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040262 obo:IAO_0000115 "Middle ear is filled with glue-like fluid instead of air." ; oboInOwl:hasDbXref "MSH:D010034", "SNOMEDCT_US:78868004", "UMLS:C0029883" ; a owl:Class ; rdfs:comment "http://patient.info/health/glue-ear-leaflet" ; rdfs:label "Glue ear" ; rdfs:subClassOf obo:HP_0000370 . obo:HP_0040263 oboInOwl:hasBroadSynonym "Difficulty opening mouth" ; oboInOwl:hasDbXref "SNOMEDCT_US:285466001", "UMLS:C0563350", "UMLS:C4280688" ; a owl:Class ; rdfs:label "Jaw ankylosis" ; rdfs:subClassOf obo:HP_0000277 . obo:HP_0040264 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw." ; oboInOwl:hasDbXref "SNOMEDCT_US:274667000", "UMLS:C0236000" ; oboInOwl:hasExactSynonym "Jaw pain" ; a owl:Class ; rdfs:label "Jaw pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0040265 obo:IAO_0000115 "Abnormal increase in muscle size and mass of one or both arms not due to training." ; oboInOwl:hasDbXref "UMLS:C4280687" ; a owl:Class ; rdfs:label "Upper limb muscle hypertrophy" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0003712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004481 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040266 oboInOwl:hasDbXref "UMLS:C4280686" ; a owl:Class ; rdfs:label "Proximal upper limb muscle hypertrophy" ; rdfs:subClassOf obo:HP_0040265 . obo:HP_0040267 oboInOwl:hasDbXref "UMLS:C4280685" ; a owl:Class ; rdfs:label "Distal upper limb muscle hypertrophy" ; rdfs:subClassOf obo:HP_0040265 . obo:HP_0040268 obo:IAO_0000115 "Increased susceptibility to middle ear infections, as manifested by recurrent episodes of middle ear infections" ; oboInOwl:hasDbXref "UMLS:C0747085" ; a owl:Class ; rdfs:label "Recurrent infections of the middle ear" ; rdfs:subClassOf obo:HP_0000370, obo:HP_0002719 . obo:HP_0040269 oboInOwl:hasDbXref "SNOMEDCT_US:48145001", "UMLS:C0149508" ; oboInOwl:hasExactSynonym "Obstruction of Eustachian tube" ; a owl:Class ; rdfs:label "Blocked Eustachian tube" ; rdfs:subClassOf obo:HP_0040115 . obo:HP_0040270 obo:IAO_0000115 "An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose." ; oboInOwl:hasDbXref "MP:0005291", "UMLS:C0151671" ; oboInOwl:hasExactSynonym "Decreased glucose tolerance", "Glucose tolerance decreased" ; a owl:Class ; rdfs:label "Impaired glucose tolerance" ; rdfs:subClassOf obo:HP_0001952 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000911 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0046323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040272 obo:IAO_0000115 "A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord." ; oboInOwl:hasDbXref "UMLS:C4280684" ; a owl:Class ; rdfs:comment "Seen in a wide-ranging variety of spinal cord processes including; simple MR artefacts, congenital anomalies etc. Characterization of the abnormal areas of T2 signal as well as their appearance on other MR imaging sequences, when combined with clinical context and laboratory investigations, will often allow a unique diagnosis, or at least aid in narrowing the differential diagnosis." ; rdfs:label "Hyperintensity of MRI T2 signal of the spinal cord" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0040273 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the intestines." ; oboInOwl:hasDbXref "NCIT:C2852", "UMLS:C4280683" ; a owl:Class ; rdfs:label "Adenocarcinoma of the intestines" ; rdfs:subClassOf obo:HP_0002672 . obo:HP_0040274 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the small intestine." ; oboInOwl:hasDbXref "NCIT:C2852", "SNOMEDCT_US:424440001", "UMLS:C0278803" ; a owl:Class ; rdfs:label "Adenocarcinoma of the small intestine" ; rdfs:subClassOf obo:HP_0040273, obo:HP_0100833 . obo:HP_0040275 obo:IAO_0000115 "A malignant epithelial tumor with a glandular organization that originates in the large intestine." ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C2852", "SNOMEDCT_US:408645001", "UMLS:C1319315" ; a owl:Class ; rdfs:label "Adenocarcinoma of the large intestine" ; rdfs:subClassOf obo:HP_0040273, obo:HP_0100834 . obo:HP_0040276 dcterms:creator ; oboInOwl:hasDbXref "NCIT:C2852", "UMLS:C0338106" ; a owl:Class ; rdfs:label "Adenocarcinoma of the colon" ; rdfs:subClassOf obo:HP_0040275, obo:HP_0100273 . obo:HP_0040277 oboInOwl:hasDbXref "NCIT:C3262" ; a owl:Class ; rdfs:label "Neoplasm of the pituitary gland" ; rdfs:subClassOf obo:HP_0012503, obo:HP_0100568 . obo:HP_0040278 obo:IAO_0000115 "A benign tumor (adenoma) of the pituitary gland" ; a owl:Class ; rdfs:comment "Associated with increased prolactin in the blood (hyperprolactinemia)" ; rdfs:label "Prolactinoma" ; rdfs:subClassOf obo:HP_0012503 . obo:HP_0040279 obo:IAO_0000115 "Class to represent frequency of phenotypic abnormalities within a patient cohort." ; dcterms:creator ; a owl:Class ; rdfs:comment "Aligned with Orphanet" ; rdfs:label "Frequency" ; rdfs:subClassOf obo:HP_0000001 . obo:HP_0040280 obo:IAO_0000115 "Always present, i.e. in 100% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453310" ; oboInOwl:hasExactSynonym "Obligate (100%)" ; a owl:Class ; rdfs:label "Obligate" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040281 obo:IAO_0000115 "Present in 80% to 99% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453311" ; oboInOwl:hasExactSynonym "Very frequent (99-80%)" ; a owl:Class ; rdfs:label "Very frequent" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040282 obo:IAO_0000115 "Present in 30% to 79% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453312" ; oboInOwl:hasExactSynonym "Frequent (79-30%)" ; a owl:Class ; rdfs:label "Frequent" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040283 obo:IAO_0000115 "Present in 5% to 29% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453313" ; oboInOwl:hasExactSynonym "Occasional (29-5%)" ; a owl:Class ; rdfs:label "Occasional" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040284 obo:IAO_0000115 "Present in 1% to 4% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453314" ; oboInOwl:hasExactSynonym "Very rare (<4-1%)", "Very rare (<4-1%)" ; a owl:Class ; rdfs:label "Very rare" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040285 obo:IAO_0000115 "Present in 0% of the cases." ; dcterms:creator ; oboInOwl:hasDbXref "ORPHA:453315" ; oboInOwl:hasExactSynonym "Excluded (0%)" ; a owl:Class ; rdfs:label "Excluded" ; rdfs:subClassOf obo:HP_0040279 . obo:HP_0040286 obo:IAO_0000115 "A structural anomaly of the muscles of the trunk and head." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of axial muscles" ; a owl:Class ; rdfs:label "Abnormal axial muscle morphology" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003897 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040287 dcterms:creator ; a owl:Class ; rdfs:label "Axial muscle atrophy" ; rdfs:subClassOf obo:HP_0040286 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003897 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040288 obo:IAO_0000115 "The condition of inability to eat normally treated by placement of a thin tube through the nose into the stomach that is then used to carry food." ; a owl:Class ; rdfs:label "Nasogastric tube feeding" ; rdfs:subClassOf obo:HP_0033454 . obo:HP_0040289 obo:IAO_0000115 "Recurrent episodes of abnormally low levels of neutrophils in the body (neutropenia)." ; oboInOwl:hasExactSynonym "CyN" ; a owl:Class ; rdfs:label "Cyclic neutropenia" ; rdfs:subClassOf obo:HP_0001875 . obo:HP_0040290 a owl:Class ; rdfs:label "obsolete Abnormality of skeletal muscles" ; owl:deprecated true . obo:HP_0040291 oboInOwl:hasExactSynonym "Steatosis of skeletal muscle", "Steatosis of skeletal muscles" ; a owl:Class ; rdfs:label "Skeletal muscle steatosis" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_622 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0018254 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040292 oboInOwl:hasExactSynonym "Hemiplegia (left)" ; a owl:Class ; rdfs:label "Left hemiplegia" ; rdfs:subClassOf obo:HP_0002301 . obo:HP_0040293 oboInOwl:hasExactSynonym "Hemiplegia (right)" ; a owl:Class ; rdfs:label "Right hemiplegia" ; rdfs:subClassOf obo:HP_0002301 . obo:HP_0040294 oboInOwl:hasExactSynonym "Duplication of tongue", "Tongue duplicated", "Tongue duplication" ; a owl:Class ; rdfs:label "Duplicated tongue" ; rdfs:subClassOf obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040295 oboInOwl:hasExactSynonym "Double upper lip" ; a owl:Class ; rdfs:label "Duplication of the upper lip" ; rdfs:subClassOf obo:HP_0000177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040296 obo:IAO_0000115 "Anomalous anatomical placement of the eyebrow." ; oboInOwl:hasExactSynonym "Abnormal location of eyebrows", "Abnormally placed eyebrows" ; a owl:Class ; rdfs:label "Abnormal location of the eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040297 obo:IAO_0000115 "Preauricular sinus is an occasional finding and most frequently appears as a small pit close to the anterior margin of the ascending portion of the helix. The opening has also been reported along the postero superior margin of the helix, the tragus or the lobule. Preauricular sinus may lead to the formation of a subcutaneous cyst that is intimately related to the tragal cartilage and the anterior crus of the helix." ; a owl:Class ; rdfs:label "Preauricular cyst" ; rdfs:subClassOf obo:HP_0000383 . obo:HP_0040298 oboInOwl:hasExactSynonym "Hyperplastic endometrium" ; a owl:Class ; rdfs:label "Hyperplasia of the endometrium" ; rdfs:subClassOf obo:HP_0030126 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001295 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040299 dcterms:creator ; oboInOwl:hasExactSynonym "Low fatty acids level" ; a owl:Class ; rdfs:label "Decreased circulating free fatty acid level" ; rdfs:subClassOf obo:HP_0040300 . obo:HP_0040300 obo:IAO_0000115 "Any deviation from the normal concentration of a free fatty acid in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating free fatty acid level" ; a owl:Class ; rdfs:label "Abnormal circulating free fatty acid concentration" ; rdfs:subClassOf obo:HP_0004359 . obo:HP_0040301 obo:IAO_0000115 "An increased concentration of glycerol in the urine." ; a owl:Class ; rdfs:label "Increased urinary glycerol" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040302 obo:IAO_0000115 "Increased concentration of glycerol in the blood." ; oboInOwl:hasRelatedSynonym "Pseudohypertriglyceridemia" ; a owl:Class ; rdfs:comment "In glycerol kinase deficiency, the increased glycerol concentration has been noted to cause false-positive results of hypertriglyceridemia, a phenomenon called pseudohypertriglyceridemia." ; rdfs:label "Hyperglycerolemia" ; rdfs:subClassOf obo:HP_0031795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040303 oboInOwl:hasExactSynonym "Low serum iron" ; a owl:Class ; rdfs:label "Decreased serum iron" ; rdfs:subClassOf obo:HP_0040130 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18248 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040304 oboInOwl:hasExactSynonym "Duplicate sella turcica", "Duplicated sella turcica" ; a owl:Class ; rdfs:label "Duplication of the sella turcica" ; rdfs:subClassOf obo:HP_0002679 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040305 obo:IAO_0000115 "Increased desire for sexual activity on the part of a male." ; a owl:Class ; rdfs:label "Increased male libido" ; rdfs:subClassOf obo:HP_0040307, obo:HP_0046503 . obo:HP_0040306 obo:IAO_0000115 "Reduced desire for sexual activity on the part of a male." ; a owl:Class ; rdfs:label "Decreased male libido" ; rdfs:subClassOf obo:HP_0040307, obo:HP_0046504 . obo:HP_0040307 obo:IAO_0000115 "A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity" ; a owl:Class ; rdfs:label "Male sexual dysfunction" ; rdfs:subClassOf obo:HP_0012874 . obo:HP_0040308 obo:IAO_0000115 "Inability of a male to reach orgasm." ; a owl:Class ; rdfs:label "Male anorgasmia" ; rdfs:subClassOf obo:HP_0040307, obo:HP_0046502 . obo:HP_0040309 oboInOwl:hasExactSynonym "Large jaw" ; a owl:Class ; rdfs:label "Increased size of the mandible" ; rdfs:subClassOf obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040310 obo:IAO_0000115 "An inflammatory arthritis characterized by purulent synovial fluid with neutrophil accumulation, but with negative cultures." ; dcterms:creator ; a owl:Class ; rdfs:comment "This form of arthritis is termed 'sterile' because bacetriology returns negative results even though the clinical presentation resembles that of infectious arthritis." ; rdfs:label "Sterile arthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0040311 obo:IAO_0000115 "Polyarthritis refers to a joint disease that involves at least five joints. One or more signs of inflammation, including pain, movement restriction, swelling, warmth, and redness, are seen in the joints involved. Polyarthritis is defined as symmetric if at least half of the joints involved are affected in a symmetric (i.e., both right and the left) fashion." ; dcterms:creator ; a owl:Class ; rdfs:comment "In the event that pain is the only symptom, it is difficult to differentiate polyarthritis from the causes of polyarticular joint pain, such as fibromyalgia or osteoarthritis." ; rdfs:label "Symmetric polyarthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0040312 oboInOwl:hasExactSynonym "Arthritis of temporomandibular joint" ; a owl:Class ; rdfs:label "Temporomandibular arthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0040313 obo:IAO_0000115 "A type of arthritis that affects up to four joints in the first six months of disease." ; a owl:Class ; rdfs:label "Oligoarthritis" ; rdfs:subClassOf obo:HP_0001369 . obo:HP_0040314 obo:IAO_0000115 "The vagina ends in a blind pouch or sac rather than being connected to the internal genitalia." ; oboInOwl:hasExactSynonym "Blind-ended vagina" ; a owl:Class ; rdfs:label "Blind vagina" ; rdfs:subClassOf obo:HP_0000142 . obo:HP_0040315 obo:IAO_0000115 "An abnormal accumulation of fluid and swelling in the tongue." ; oboInOwl:hasExactSynonym "Tongue oedema" ; a owl:Class ; rdfs:label "Tongue edema" ; rdfs:subClassOf obo:HP_0000157, obo:HP_0000969 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040316 obo:IAO_0100001 "HP:0030261" ; a owl:Class ; rdfs:label "obsolete Aplasia of the penis" ; owl:deprecated true . obo:HP_0040317 obo:IAO_0000115 "An abnormal blue color of the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "Blue or green urine coloration may be observed due to certain dyes used for tests of kidney and bladder function, some medications, and disorders including familial benign hypercalcemia and urinary tract infections caused by pseudomonas bacteria." ; rdfs:label "Blue urine" ; rdfs:subClassOf obo:HP_0012086 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000318 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040318 obo:IAO_0000115 "An abnormal red color of the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "http://www.health.harvard.edu/newsletter_article/red-brown-green-urine-colors-and-what-they-might-mean" ; rdfs:label "Red urine" ; rdfs:subClassOf obo:HP_0012086 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000322 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001088 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040319 obo:IAO_0000115 "An abnormal dark color of the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "http://www.health.harvard.edu/newsletter_article/red-brown-green-urine-colors-and-what-they-might-mean" ; rdfs:label "Dark urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0040320 obo:IAO_0000115 "An abnormal red-brown color of the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "red brown urine" ; a owl:Class ; rdfs:comment "http://www.health.harvard.edu/newsletter_article/red-brown-green-urine-colors-and-what-they-might-mean" ; rdfs:label "Red-brown urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0040321 obo:IAO_0000115 "An abnormal dark-yellow color of the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "http://www.health.harvard.edu/newsletter_article/red-brown-green-urine-colors-and-what-they-might-mean" ; rdfs:label "Dark yellow urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0040322 obo:IAO_0000115 "An abnormal purple color of the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "http://www.health.harvard.edu/newsletter_article/red-brown-green-urine-colors-and-what-they-might-mean" ; rdfs:label "Purple urine" ; rdfs:subClassOf obo:HP_0012086 . obo:HP_0040323 obo:IAO_0000115 "Redness of the skin of the eyelids, caused by hyperemia of the capillaries in the lower layers of the skin." ; oboInOwl:hasExactSynonym "Erythema of eyelid", "Erythema of the eyelids", "Eyelid erythema", "Red eyelid" ; a owl:Class ; rdfs:label "Eyelid erythema" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0010783 . obo:HP_0040324 obo:IAO_0000115 "In a heliotrope rash, the color of the skin turns to violet, which is the color of the heliotrope flower." ; dcterms:creator ; oboInOwl:hasExactSynonym "Heliotrope erythema" ; a owl:Class ; rdfs:comment "Heliotrope rash occurs during the initial phase of the idiopathic inflammatory myositis (particularly dermatomyositis). Heliotrope rash is a characteristic symptom of Dermatomyositis." ; rdfs:label "Heliotrope rash" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0040325 obo:IAO_0000115 "A cutaneous eruption that consists of multiple (at least two) concentric erythematous rings." ; dcterms:creator ; a owl:Class ; rdfs:label "Bull's eye rash" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_0040326 obo:IAO_0000115 "Underdevelopment of the olfactory bulb." ; oboInOwl:hasExactSynonym "Hypoplasia of olfactory bulb", "Hypoplastic olfactory bulb" ; a owl:Class ; rdfs:label "Hypoplasia of the olfactory bulb" ; rdfs:subClassOf obo:HP_0002977, obo:HP_0040327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040327 obo:IAO_0000115 "An abnormal morphology of the olfactory bulb (bulbus olfactorius), which is involved in olfaction, i.e. the sense of smell." ; a owl:Class ; rdfs:label "Abnormal morphology of the olfactory bulb" ; rdfs:subClassOf obo:HP_0100547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0040328 obo:IAO_0000115 "An abnormal area of increased brightness (hyperintensity) that is limited to one particular area." ; dcterms:creator ; a owl:Class ; rdfs:label "Focal hyperintensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007042, obo:HP_0030890 . obo:HP_0040329 obo:IAO_0000115 "An abnormal area of increased brightness (hyperintensity) that occurs in several distinct areas." ; dcterms:creator ; a owl:Class ; rdfs:label "Multifocal hyperintensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007052, obo:HP_0030890 . obo:HP_0040330 obo:IAO_0000115 "Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together." ; dcterms:creator ; a owl:Class ; rdfs:label "Confluent hyperintensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007204, obo:HP_0030890 . obo:HP_0040331 dcterms:creator ; a owl:Class ; rdfs:label "Focal hypointensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007042, obo:HP_0007103 . obo:HP_0040332 dcterms:creator ; a owl:Class ; rdfs:label "Multifocal hypointensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007052, obo:HP_0007103 . obo:HP_0040333 dcterms:creator ; a owl:Class ; rdfs:label "Confluent hypointensity of cerebral white matter on MRI" ; rdfs:subClassOf obo:HP_0007103, obo:HP_0007204 . obo:HP_0040334 obo:IAO_0000115 "Chronic rhinitis accompanied by pus formation." ; dcterms:creator ; a owl:Class ; rdfs:comment "An infection of the nasal mucosa associated with pus formation. (Often secondary to a systemic infection, such as measles)" ; rdfs:label "Purulent rhinitis" ; rdfs:subClassOf obo:HP_0002257 . obo:HP_0041042 obo:IAO_0000115 "The absence of lactoferrin in neutrophil granules, which could be caused by either an isolated failure of synthesis of this protein (or the production of an antigenically unrecognizable form of lactoferrin) or a complete deficiency of specific granule production." ; dcterms:creator ; a owl:Class ; rdfs:label "Absent neutrophil lactoferrin" ; rdfs:subClassOf obo:HP_0012551 . obo:HP_0041043 obo:IAO_0000115 "An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation." ; dcterms:creator ; a owl:Class ; rdfs:label "Neutrophil nuclear clefts" ; rdfs:subClassOf obo:HP_0410310 . obo:HP_0041044 obo:IAO_0000115 "An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme." ; dcterms:creator ; a owl:Class ; rdfs:label "Low neutrophil alkaline phosphatase" ; rdfs:subClassOf obo:HP_0003282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_36080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000775 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004035 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041045 obo:IAO_0000115 "An increased number of mitochondria detected in neutrophils." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased neutrophil mitochondria" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0041046 obo:IAO_0000115 "An increased number of ribosomes detected in neutrophils." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased neutrophil ribosomes" ; rdfs:subClassOf obo:HP_0011992 . obo:HP_0041047 obo:IAO_0000115 "A compression or resistance upon the bladder outflow channel at any location from the bladder neck to urethral meatus, which usually causes lower urinary tract symptoms (LUTS)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Obstruction of bladder outlet" ; a owl:Class ; rdfs:label "Bladder outlet obstruction" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0041048 obo:IAO_0000115 "A decrease in the protein expression of GPI-anchor proteins, such as CD55 and CD59, at the cell surface, which suggests a defect in GPI-anchor biosynthesis." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased expression of GPI-anchored proteins on the cell surface" ; rdfs:subClassOf obo:HP_0031551 . obo:HP_0041049 obo:IAO_0000115 "An inability to digest starch." ; dcterms:creator ; oboInOwl:hasExactSynonym "Amylose-amylopectin intolerance", "Starch intolerance" ; a owl:Class ; rdfs:label "Starch intolerance" ; rdfs:subClassOf obo:HP_0002024 . obo:HP_0041050 obo:IAO_0000115 "Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Renal tubule cyst" ; a owl:Class ; rdfs:label "Renal tubular cyst" ; rdfs:subClassOf obo:HP_0000091, obo:HP_0000107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009773 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041051 obo:IAO_0000115 "A rare condition that is characterized by a complete loss of taste function of the tongue." ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent sense of taste", "Impaired taste sensation", "Lost taste" ; a owl:Class ; rdfs:label "Ageusia" ; rdfs:subClassOf obo:HP_0000223 . obo:HP_0041052 obo:IAO_0000115 "A developmental defect characterized by the absence of the putamen owing to its failure to develop." ; dcterms:creator ; a owl:Class ; rdfs:comment "The basal ganglia are symmetrical subcortical grey nuclei at the core of the extrapyramidal system, composed by the striatum (which comprises the putamen, caudate nucleus, olfactory tubercle, and nucleus accumbens), the pallidum, the substantia nigra, and the subthalamic nucleus. Congenital malformations of the basal ganglia deriving from defects of embryogenesis are very rare. The basal ganglia embryologically derive from the prosencephalon (or forebrain), the most rostral of the three vesicles originating from early patterning of the neural tube along the anterior-posterior axis." ; rdfs:label "Agenesis of putamen" ; rdfs:subClassOf obo:HP_0031982 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001874 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041053 obo:IAO_0100001 obo:HP_0041082 ; a owl:Class ; rdfs:label "obsolete Fractured head" ; owl:deprecated true . obo:HP_0041054 oboInOwl:consider "HP:0020110" ; a owl:Class ; rdfs:label "obsolete Fractured thoracic segment of trunk" ; owl:deprecated true . obo:HP_0041055 obo:IAO_0000115 "A partial or complete breakage of the humerus." ; oboInOwl:hasExactSynonym "Broken humerus", "Fracture of the humerus", "Humeral fracture", "Humerus fracture", "bone humerus" ; a owl:Class ; rdfs:label "Fractured humerus" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0031095, obo:HP_0041245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041056 obo:IAO_0000115 "A cruciform-shaped hyperintensity within the pons found on T2-weighted magnetic resonance imaging (MRI)." ; dcterms:creator ; a owl:Class ; rdfs:comment "It is commonly associated with atrophy of the pons, cerebellum, and putamen in multiple system atrophy (MSA). See figure 15 in PMID:29089832." ; rdfs:label "Hot cross bun sign" ; rdfs:subClassOf obo:HP_0007361 . obo:HP_0041057 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin G4 (IgG4) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgG4 in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgG4" ; rdfs:subClassOf obo:HP_0032138 . obo:HP_0041058 obo:IAO_0000115 "A lasting decrease of immunoglobulin G4 (IgG4) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgG4 in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating IgG4" ; rdfs:subClassOf obo:HP_0032138 . obo:HP_0041059 obo:IAO_0000115 "A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgG4 in blood" ; a owl:Class ; rdfs:label "Chronic (near) absent circulating IgG4" ; rdfs:subClassOf obo:HP_0041058 . obo:HP_0041060 obo:IAO_0000115 "A lasting limited decrease of immunoglobulin G4 (IgG4) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic partially decreased IgG4 in blood" ; a owl:Class ; rdfs:label "Chronic partially decreased circulating IgG4" ; rdfs:subClassOf obo:HP_0041058 . obo:HP_0041061 obo:IAO_0000115 "A partial or complete breakage of the calcaneus." ; oboInOwl:hasExactSynonym "bone calcaneus" ; a owl:Class ; rdfs:label "Fractured calcaneus" ; rdfs:subClassOf obo:HP_0008364, obo:HP_0041247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041062 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin G2 (IgG2) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgG2 in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgG2" ; rdfs:subClassOf obo:HP_0008348 . obo:HP_0041063 obo:IAO_0000115 "A lasting decrease of immunoglobulin G2 (IgG2) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgG2 in blood" ; a owl:Class ; rdfs:label "Chronic decreased cirulating IgG2" ; rdfs:subClassOf obo:HP_0008348 . obo:HP_0041064 obo:IAO_0000115 "A partial or complete breakage of the knee." ; oboInOwl:hasExactSynonym "bone knee" ; a owl:Class ; rdfs:label "Fractured knee" ; rdfs:subClassOf obo:HP_0034669, obo:HP_0041117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041065 obo:IAO_0000115 "A lasting absence of immunoglobulin G2 (IgG2) in the blood, whereby at most trace quantities of IgG2 can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgG2 in blood" ; a owl:Class ; rdfs:label "Chronic (near) absent circulating IgG2" ; rdfs:subClassOf obo:HP_0041063 . obo:HP_0041066 obo:IAO_0000115 "A lasting limited decrease of immunoglobulin G2 (IgG2) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic partially decreased IgG2 in blood" ; a owl:Class ; rdfs:label "Chronic partially decreased circulating IgG2" ; rdfs:subClassOf obo:HP_0041063 . obo:HP_0041067 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin G1 (IgG1) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgG1 in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgG1" ; rdfs:subClassOf obo:HP_0032136 . obo:HP_0041068 obo:IAO_0000115 "A lasting decrease of immunoglobulin G1 (IgG1) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgG1 in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating IgG1" ; rdfs:subClassOf obo:HP_0032136 . obo:HP_0041069 obo:IAO_0000115 "A lasting absence of immunoglobulin G1 (IgG1) in the blood, whereby at most trace quantities of IgG1 can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgG1 in blood" ; a owl:Class ; rdfs:label "Chronic (near) absent circulating IgG1" ; rdfs:subClassOf obo:HP_0041068 . obo:HP_0041070 obo:IAO_0000115 "A lasting limited decrease of immunoglobulin G1 (IgG1) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic partially decreased IgG1 in blood" ; a owl:Class ; rdfs:label "Chronic partially decreased circulating IgG1" ; rdfs:subClassOf obo:HP_0041068 . obo:HP_0041071 obo:IAO_0000115 "A temporary reduction beneath the normal level of total immunoglobulin G3 (IgG3) in the blood circulation." ; dcterms:creator ; oboInOwl:hasExactSynonym "Transient decreased IgG3 in blood" ; a owl:Class ; rdfs:label "Transient decreased circulating IgG3" ; rdfs:subClassOf obo:HP_0032137 . obo:HP_0041072 obo:IAO_0000115 "A lasting decrease of immunoglobulin G3 (IgG3) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic decreased IgG3 in blood" ; a owl:Class ; rdfs:label "Chronic decreased circulating IgG3" ; rdfs:subClassOf obo:HP_0032137 . obo:HP_0041073 obo:IAO_0000115 "A partial or complete breakage of the thoracic vertebra." ; oboInOwl:hasExactSynonym "bone thoracic vertebra" ; a owl:Class ; rdfs:label "Fractured thoracic vertebra" ; rdfs:subClassOf obo:HP_0041166, obo:HP_0100711 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041074 obo:IAO_0000115 "A lasting absence of immunoglobulin G3 (IgG3) in the blood, whereby at most trace quantities of IgG3 can be measured." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic (near) absent IgG3 in blood" ; a owl:Class ; rdfs:label "Chronic (near) absent circulating IgG3" ; rdfs:subClassOf obo:HP_0041072 . obo:HP_0041075 obo:IAO_0000115 "A lasting limited decrease of immunoglobulin G3 (IgG3) in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Chronic partially decreased IgG3 in blood" ; a owl:Class ; rdfs:label "Chronic partially decreased circulating IgG3" ; rdfs:subClassOf obo:HP_0041072 . obo:HP_0041076 obo:IAO_0000115 "An abnormal deviation from normal levels of immunoglobulins in body fluids, such as mucous." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal immunoglobulin level in body fluid" ; rdfs:subClassOf obo:HP_0005372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041077 obo:IAO_0000115 "An elevation from normal levels of immunoglobulins in body fluids, such as mucous." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased immunoglobulin level in body fluid" ; rdfs:subClassOf obo:HP_0041076 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041078 obo:IAO_0000115 "An reduction from normal levels of immunoglobulins in body fluids, such as mucous." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased immunoglobulin level in body fluid" ; rdfs:subClassOf obo:HP_0041076 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019814 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041079 obo:IAO_0000115 "The percentage of fat as a part of total body weight below the norm, usually defined as less than 14% for females and less than 8% for males." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased adipose tissue percentage" ; a owl:Class ; rdfs:label "Decreased body fat percentage" ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0041080 obo:IAO_0000115 "A deviation from the normal proportion of exhausted T cell relative to T cell in the blood." ; a owl:Class ; rdfs:comment "T cell exhaustion is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumors." ; rdfs:label "Abnormal proportion of exhausted T cells" ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0011025 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041081 obo:IAO_0000115 "Bone fracture anywhere in the tibia, fibula, or ankle." ; dcterms:creator ; oboInOwl:hasExactSynonym "Fracture of the lower leg", "Lower extremity fracture", "Lower limb fracture" ; a owl:Class ; rdfs:label "Fractured lower leg" ; rdfs:subClassOf obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004251 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041082 obo:IAO_0000115 "A partial or complete breakage of the skull." ; oboInOwl:hasAlternativeId "HP:0041053" ; a owl:Class ; rdfs:label "Fractured skull" ; rdfs:subClassOf obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041083 obo:IAO_0000115 "A partial or complete breakage of the phalanx." ; oboInOwl:hasExactSynonym "bone phalanx" ; a owl:Class ; rdfs:label "Fractured phalanx" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0011297, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003221 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041084 obo:IAO_0000115 "A fracture of the thoracic vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." ; dcterms:creator ; oboInOwl:hasExactSynonym "Compression fractured thoracic vertebra", "Wedge fractured thoracic vertebra" ; a owl:Class ; rdfs:label "Compression-fractured thoracic vertebra" ; rdfs:subClassOf obo:HP_0041073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040040 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002347 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041085 obo:IAO_0000115 "A fracture of the vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." ; dcterms:creator ; oboInOwl:hasExactSynonym "Compression fractured vertebra", "Wedge fractured vertebra" ; a owl:Class ; rdfs:label "Compression-fractured vertebra" ; rdfs:subClassOf obo:HP_0041166 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040040 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041086 obo:IAO_0000115 "A fracture of the cervical vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." ; dcterms:creator ; oboInOwl:hasExactSynonym "Compression fractured cervical vertebra", "Wedge fractured cervical vertebra" ; a owl:Class ; rdfs:label "Compression-fractured cervical vertebra" ; rdfs:subClassOf obo:HP_0041167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040040 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041087 obo:IAO_0000115 "A fracture of the lumbar vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." ; dcterms:creator ; oboInOwl:hasExactSynonym "Compression fractured lumbar vertebra", "Wedge fractured lumbar vertebra" ; a owl:Class ; rdfs:label "Compression-fractured lumbar vertebra" ; rdfs:subClassOf obo:HP_0041168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040040 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041088 obo:IAO_0000115 "A fractured in which a fragment of the humerus tears away from the main mass of bone as a result of physical trauma." ; dcterms:creator ; a owl:Class ; rdfs:label "Avulsion fractured humerus" ; rdfs:subClassOf obo:HP_0041055 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040041 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041089 obo:IAO_0000115 "A fractured in which a fragment of the tibia tears away from the main mass of bone as a result of physical trauma." ; dcterms:creator ; a owl:Class ; rdfs:label "Avulsion fractured tibia" ; rdfs:subClassOf obo:HP_0041143 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040041 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041090 dcterms:creator ; a owl:Class ; rdfs:label "obsolete Avulsion fractured pelvic region of trunk" ; owl:deprecated true . obo:HP_0041091 obo:IAO_0000115 "A fractured in which the fragment of the epiphysis of femur bone tears away from the main mass of bone as a result of physical trauma." ; dcterms:creator ; a owl:Class ; rdfs:label "Avulsion fractured epiphysis of femur" ; rdfs:subClassOf obo:HP_0041189 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040041 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041092 obo:IAO_0000115 "Heightened emotional reactivity to environmental stimuli, including emotions of others." ; dcterms:creator ; oboInOwl:hasExactSynonym "Highly sensitive", "Hypersensitivity", "Overly sensitive" ; a owl:Class ; rdfs:label "Emotional hypersensitivity" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0041093 obo:IAO_0000115 "A nail dystrophy that is preseents as grooved lines that run from side to side on the fingernail or the toenail that may look like indentations or ridges on the nail plate. They are caused by temporary disruption in the growth of proximal nail matrix. Trauma is usually the initiating factor such as infections, severe medical illnesses, major surgery/anesthesia, medication side effects, and autoimmune disease." ; dcterms:creator ; oboInOwl:hasExactSynonym "Beau lines", "Ladder nail", "Ladder nail sign" ; a owl:Class ; rdfs:label "Beau's lines" ; rdfs:subClassOf obo:HP_0008404 . obo:HP_0041094 obo:IAO_0000115 "Continuous or nearly continuous configuration of the cartilaginous tracheal ring." ; dcterms:creator ; oboInOwl:hasExactSynonym "CTRD", "Complete tracheal ring deformity", "Complete tracheal rings" ; a owl:Class ; rdfs:comment "The trachea is surrounded by 16-20 rings of hyaline cartilage; these rings are incomplete and horseshoe-shaped (C-shaped). In complete tracheal rings, the rings encircle the entire trachea (O-shaped) or nearly the entire trachea. Pulmonary artery sling is a vascular anomaly often seen in CTRD in which the left pulmonary artery (LPA) originates from the right pulmonary artery (RPA) and encircles the distal trachea and right primary bronchus before entering the hilum of the left lung. Pumonary artery sling should be coded separately (HP:0004961)." ; rdfs:label "Complete tracheal ring" ; rdfs:subClassOf obo:HP_0004468 . obo:HP_0041095 obo:IAO_0000115 "Abnormally reduced blood flow pulsatility in in the middle cerebral artery (MCA). The pulsatility index (PI) is calculated using the following equation PI = (peak systolic velocity-end-diastolic velocity)/mean velocity." ; dcterms:creator ; a owl:Class ; rdfs:comment "Arterial blood flow pulsatility, as assessed by Doppler, is influenced by many factors, including the differences in resistance between vascular beds upstream and downstream of the artery assessed, intrinsic properties of the artery, fetal heart rate and cardiac output. In the presence of structural heart disease, reduced cerebral oxygen content, abnormal cardiac output, anatomical substrate that impedes cerebral blood flow and differences in systemic and placental vascular resistance may all potentially contribute to changes in middle cerebral artery pulsatility index (MCA-PI). Fetuses with severe left heart obstruction, including hypoplastic left heart syndrome and isolated coarctation associated with retrograde distal arch flow, have altered cerebral blood flow with reduced MCA-PI. These changes in cerebral blood flow potentially contribute to the neurodevelopmental abnormalities frequently observed in affected infants and children." ; rdfs:label "Decreased middle cerebral artery pulsatility index" ; rdfs:subClassOf obo:HP_0034190 . obo:HP_0041114 obo:IAO_0000115 "A partial or complete breakage of the metaphysis of femur." ; oboInOwl:hasExactSynonym "bone metaphysis of femur" ; a owl:Class ; rdfs:label "Fractured metaphysis of femur" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0006489 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041115 obo:IAO_0000115 "A partial or complete breakage of the right clavicle." ; oboInOwl:hasExactSynonym "bone right clavicle" ; a owl:Class ; rdfs:label "Fractured right clavicle" ; rdfs:subClassOf obo:HP_0041144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008255 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041116 obo:IAO_0000115 "A partial or complete breakage of the left clavicle." ; oboInOwl:hasExactSynonym "bone left clavicle" ; a owl:Class ; rdfs:label "Fractured left clavicle" ; rdfs:subClassOf obo:HP_0041144 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008256 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041117 obo:IAO_0000115 "A partial or complete breakage of the lower limb segment." ; oboInOwl:hasExactSynonym "bone lower limb segment" ; a owl:Class ; rdfs:label "Fractured lower limb segment" ; rdfs:subClassOf obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008784 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041118 obo:IAO_0000115 "A partial or complete breakage of the upper limb segment." ; oboInOwl:hasExactSynonym "bone upper limb segment" ; a owl:Class ; rdfs:label "Fractured upper limb segment" ; rdfs:subClassOf obo:HP_0040064 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008785 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041119 obo:IAO_0000115 "A partial or complete breakage of the metacarpus skeleton." ; oboInOwl:hasExactSynonym "bone metacarpus skeleton" ; a owl:Class ; rdfs:label "Fractured metacarpus skeleton" ; rdfs:subClassOf obo:HP_0004277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010544 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041121 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of fifth metacarpal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of fifth metacarpal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of fifth metacarpal bone" ; rdfs:subClassOf obo:HP_0009189, obo:HP_0010226, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011104 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041143 obo:IAO_0000115 "A partial or complete breakage of the tibia." ; oboInOwl:hasExactSynonym "Broken tibia", "Fracture of the tibia", "Tibial fracture", "bone tibia" ; a owl:Class ; rdfs:label "Fractured tibia" ; rdfs:subClassOf obo:HP_0002992, obo:HP_0003084, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041144 obo:IAO_0000115 "A partial or complete breakage of the clavicle bone." ; oboInOwl:hasExactSynonym "bone clavicle bone" ; a owl:Class ; rdfs:label "Fractured clavicle bone" ; rdfs:subClassOf obo:HP_0000889, obo:HP_0003084, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041145 obo:IAO_0000115 "A partial or complete breakage of the acetabular part of hip bone." ; oboInOwl:hasExactSynonym "bone acetabular part of hip bone" ; a owl:Class ; rdfs:label "Fractured acetabular part of hip bone" ; rdfs:subClassOf obo:HP_0003170, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001269 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041146 obo:IAO_0000115 "A partial or complete breakage of the coccyx." ; oboInOwl:hasExactSynonym "bone coccyx" ; a owl:Class ; rdfs:label "Fractured coccyx" ; rdfs:subClassOf obo:HP_0008519, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041147 obo:IAO_0000115 "A partial or complete breakage of the epiphysis." ; oboInOwl:hasExactSynonym "bone epiphysis" ; a owl:Class ; rdfs:label "Fractured epiphysis" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0100168 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041149 obo:IAO_0000115 "A partial or complete breakage of the navicular bone of pes." ; oboInOwl:hasExactSynonym "bone navicular bone of pes" ; a owl:Class ; rdfs:label "Fractured navicular bone of pes" ; rdfs:subClassOf obo:HP_0041247, obo:HP_0100339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041150 obo:IAO_0000115 "A partial or complete breakage of the cuboid bone." ; oboInOwl:hasExactSynonym "bone cuboid bone" ; a owl:Class ; rdfs:label "Fractured cuboid bone" ; rdfs:subClassOf obo:HP_0041226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001455 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041152 obo:IAO_0000115 "A partial or complete breakage of the sternoclavicular joint." ; oboInOwl:hasExactSynonym "bone sternoclavicular joint" ; a owl:Class ; rdfs:label "Fractured sternoclavicular joint" ; rdfs:subClassOf obo:HP_0009810 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001469 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041153 obo:IAO_0000115 "A fracture or multiple fractures of one or more of three bones in the ankle joint: the tibia (shinbone), the fibula (outer ankle bone), and the talus (which is the bone that connects your leg to your foot)." ; oboInOwl:hasExactSynonym "bone ankle joint" ; a owl:Class ; rdfs:label "Fractured ankle" ; rdfs:subClassOf obo:HP_0020110, obo:HP_0034673 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001488 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041154 obo:IAO_0000115 "A partial or complete breakage of the elbow joint." ; oboInOwl:hasExactSynonym "bone elbow joint" ; a owl:Class ; rdfs:label "Fractured elbow joint" ; rdfs:subClassOf obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041155 obo:IAO_0000115 "A partial or complete breakage of the mandible." ; oboInOwl:hasExactSynonym "bone mandible" ; a owl:Class ; rdfs:label "Fractured mandible" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0041234 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041156 obo:IAO_0000115 "A partial or complete breakage of the orbit of skull." ; oboInOwl:hasExactSynonym "bone orbit of skull" ; a owl:Class ; rdfs:label "Fractured orbit of skull" ; rdfs:subClassOf obo:HP_3000030 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041157 obo:IAO_0000115 "A partial or complete breakage of the larynx." ; oboInOwl:hasExactSynonym "bone larynx" ; a owl:Class ; rdfs:label "Fractured larynx" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041158 oboInOwl:consider "HP:0020110" ; a owl:Class ; rdfs:label "obsolete Fractured trunk" ; owl:deprecated true . obo:HP_0041159 obo:IAO_0000115 "A partial or complete breakage of the rib." ; oboInOwl:hasExactSynonym "bone rib" ; a owl:Class ; rdfs:label "Fractured rib" ; rdfs:subClassOf obo:HP_0000772, obo:HP_0003084, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041161 oboInOwl:consider "HP:0020110" ; a owl:Class ; rdfs:label "obsolete Fractured pelvic region of trunk" ; owl:deprecated true . obo:HP_0041162 obo:IAO_0000115 "A partial or complete breakage of a metatarsal bone." ; oboInOwl:hasExactSynonym "Broken metatarsal", "Broken metatarsal bone" ; oboInOwl:hasNarrowSynonym "Metatarsal fracture" ; a owl:Class ; rdfs:label "Metatarsal fracture" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0020110, obo:HP_0041117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041163 obo:IAO_0000115 "A partial or complete breakage of the manual digit." ; oboInOwl:hasExactSynonym "bone manual digit" ; a owl:Class ; rdfs:label "Fractured manual digit" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0005922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041164 obo:IAO_0000115 "A partial or complete breakage of the talus." ; oboInOwl:hasExactSynonym "bone talus" ; a owl:Class ; rdfs:label "Fractured talus" ; rdfs:subClassOf obo:HP_0008365, obo:HP_0041247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041165 obo:IAO_0000115 "A partial or complete breakage of the maxilla." ; oboInOwl:hasExactSynonym "bone maxilla" ; a owl:Class ; rdfs:label "Fractured maxilla" ; rdfs:subClassOf obo:HP_0000326, obo:HP_0041234 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041166 obo:IAO_0000115 "A partial or complete breakage of the vertebra." ; oboInOwl:hasExactSynonym "bone vertebra" ; a owl:Class ; rdfs:label "Fractured vertebra" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002412 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041167 obo:IAO_0000115 "A partial or complete breakage of the cervical vertebra." ; oboInOwl:hasExactSynonym "bone cervical vertebra" ; a owl:Class ; rdfs:label "Fractured cervical vertebra" ; rdfs:subClassOf obo:HP_0041166, obo:HP_0046508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041168 obo:IAO_0000115 "A partial or complete breakage of the lumbar vertebra." ; oboInOwl:hasExactSynonym "bone lumbar vertebra" ; a owl:Class ; rdfs:label "Fractured lumbar vertebra" ; rdfs:subClassOf obo:HP_0041166, obo:HP_0100712 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002414 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041172 obo:IAO_0000115 "A partial or complete breakage of the fused sacrum." ; oboInOwl:hasExactSynonym "bone fused sacrum" ; a owl:Class ; rdfs:label "Fractured fused sacrum" ; rdfs:subClassOf obo:HP_0005107, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041173 obo:IAO_0000115 "A partial or complete breakage of the metacarpophalangeal joint." ; oboInOwl:hasExactSynonym "bone metacarpophalangeal joint" ; a owl:Class ; rdfs:label "Fractured metacarpophalangeal joint" ; rdfs:subClassOf obo:HP_0005922, obo:HP_0009810, obo:HP_0011911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003695 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041174 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of manus." ; oboInOwl:hasExactSynonym "bone distal phalanx of manus" ; a owl:Class ; rdfs:label "Fractured distal phalanx of manus" ; rdfs:subClassOf obo:HP_0009832, obo:HP_0041218, obo:HP_0041241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003865 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041175 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of pes." ; oboInOwl:hasExactSynonym "bone middle phalanx of pes" ; a owl:Class ; rdfs:label "Fractured middle phalanx of pes" ; rdfs:subClassOf obo:HP_0010183, obo:HP_0041240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041176 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of manual digit 2." ; oboInOwl:hasExactSynonym "bone distal phalanx of manual digit 2" ; a owl:Class ; rdfs:label "Fractured distal phalanx of manual digit 2" ; rdfs:subClassOf obo:HP_0009542, obo:HP_0041174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004311 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041177 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of manual digit 3." ; oboInOwl:hasExactSynonym "bone distal phalanx of manual digit 3" ; a owl:Class ; rdfs:label "Fractured distal phalanx of manual digit 3" ; rdfs:subClassOf obo:HP_0009357, obo:HP_0041174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004312 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041178 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of manual digit 4." ; oboInOwl:hasExactSynonym "bone distal phalanx of manual digit 4" ; a owl:Class ; rdfs:label "Fractured distal phalanx of manual digit 4" ; rdfs:subClassOf obo:HP_0009282, obo:HP_0041174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004313 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041179 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of manual digit 5." ; oboInOwl:hasExactSynonym "bone distal phalanx of manual digit 5" ; a owl:Class ; rdfs:label "Fractured distal phalanx of manual digit 5" ; rdfs:subClassOf obo:HP_0004225, obo:HP_0041174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004314 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041180 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of pedal digit 1." ; oboInOwl:hasExactSynonym "bone distal phalanx of pedal digit 1" ; a owl:Class ; rdfs:label "Fractured distal phalanx of pedal digit 1" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0041218, obo:HP_0041240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004315 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041181 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx of pedal digit 3." ; oboInOwl:hasExactSynonym "bone distal phalanx of pedal digit 3" ; a owl:Class ; rdfs:label "Fractured distal phalanx of pedal digit 3" ; rdfs:subClassOf obo:HP_0010368, obo:HP_0041218, obo:HP_0041240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041182 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of manual digit 2." ; oboInOwl:hasExactSynonym "bone middle phalanx of manual digit 2" ; a owl:Class ; rdfs:label "Fractured middle phalanx of manual digit 2" ; rdfs:subClassOf obo:HP_0009543, obo:HP_0041236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041183 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of manual digit 3." ; oboInOwl:hasExactSynonym "bone middle phalanx of manual digit 3" ; a owl:Class ; rdfs:label "Fractured middle phalanx of manual digit 3" ; rdfs:subClassOf obo:HP_0004172, obo:HP_0041236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004321 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041184 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of manual digit 4." ; oboInOwl:hasExactSynonym "bone middle phalanx of manual digit 4" ; a owl:Class ; rdfs:label "Fractured middle phalanx of manual digit 4" ; rdfs:subClassOf obo:HP_0009283, obo:HP_0041236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041185 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of manual digit 5." ; oboInOwl:hasExactSynonym "bone middle phalanx of manual digit 5" ; a owl:Class ; rdfs:label "Fractured middle phalanx of manual digit 5" ; rdfs:subClassOf obo:HP_0004219, obo:HP_0041236 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041186 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of pedal digit 3." ; oboInOwl:hasExactSynonym "bone middle phalanx of pedal digit 3" ; a owl:Class ; rdfs:label "Fractured middle phalanx of pedal digit 3" ; rdfs:subClassOf obo:HP_0010369, obo:HP_0041175 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041187 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of pedal digit 1." ; oboInOwl:hasExactSynonym "bone proximal phalanx of pedal digit 1" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of pedal digit 1" ; rdfs:subClassOf obo:HP_0010052, obo:HP_0041240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041188 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of manual digit 1." ; oboInOwl:hasExactSynonym "bone proximal phalanx of manual digit 1" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of manual digit 1" ; rdfs:subClassOf obo:HP_0041239, obo:HP_0041243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041189 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of femur." ; oboInOwl:hasExactSynonym "bone epiphysis of femur" ; a owl:Class ; rdfs:label "Fractured epiphysis of femur" ; rdfs:subClassOf obo:HP_0006499, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041190 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of second metacarpal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of second metacarpal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of second metacarpal bone" ; rdfs:subClassOf obo:HP_0009189, obo:HP_0010220, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004392 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041191 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of third metacarpal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of third metacarpal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of third metacarpal bone" ; rdfs:subClassOf obo:HP_0009189, obo:HP_0010222, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004393 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041192 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of fourth metacarpal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of fourth metacarpal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of fourth metacarpal bone" ; rdfs:subClassOf obo:HP_0009189, obo:HP_0010224, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004394 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041193 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of first metatarsal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of first metatarsal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of first metatarsal bone" ; rdfs:subClassOf obo:HP_0010153, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004395 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041194 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of second metatarsal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of second metatarsal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of second metatarsal bone" ; rdfs:subClassOf obo:HP_0010630, obo:HP_0040034, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041195 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of third metatarsal bone." ; oboInOwl:hasExactSynonym "bone epiphysis of third metatarsal bone" ; a owl:Class ; rdfs:label "Fractured epiphysis of third metatarsal bone" ; rdfs:subClassOf obo:HP_0010630, obo:HP_0010672, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041196 obo:IAO_0000115 "A partial or complete breakage of the distal epiphysis of radius." ; oboInOwl:hasExactSynonym "bone distal epiphysis of radius" ; a owl:Class ; rdfs:label "Fractured distal epiphysis of radius" ; rdfs:subClassOf obo:HP_0003841, obo:HP_0010597, obo:HP_0040072, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041197 obo:IAO_0000115 "A partial or complete breakage of the proximal epiphysis of first metacarpal bone." ; oboInOwl:hasExactSynonym "bone proximal epiphysis of first metacarpal bone" ; a owl:Class ; rdfs:label "Fractured proximal epiphysis of first metacarpal bone" ; rdfs:subClassOf obo:HP_0010019, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004422 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041198 obo:IAO_0000115 "A partial or complete breakage of the proximal epiphysis of middle phalanx of manual digit 3." ; oboInOwl:hasExactSynonym "bone proximal epiphysis of middle phalanx of manual digit 3" ; a owl:Class ; rdfs:label "Fractured proximal epiphysis of middle phalanx of manual digit 3" ; rdfs:subClassOf obo:HP_0009325, obo:HP_0041209 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041199 obo:IAO_0000115 "A partial or complete breakage of the interphalangeal joint." ; oboInOwl:hasExactSynonym "bone interphalangeal joint" ; a owl:Class ; rdfs:label "Fractured interphalangeal joint" ; rdfs:subClassOf obo:HP_0011297 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006658 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041200 obo:IAO_0000115 "A partial or complete breakage of the sternal end of clavicle." ; oboInOwl:hasExactSynonym "bone sternal end of clavicle" ; a owl:Class ; rdfs:label "Fractured sternal end of clavicle" ; rdfs:subClassOf obo:HP_0000889, obo:HP_0003084, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006805 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041209 obo:IAO_0000115 "A partial or complete breakage of the epiphysis of middle phalanx of manus." ; oboInOwl:hasExactSynonym "bone epiphysis of middle phalanx of manus" ; a owl:Class ; rdfs:label "Fractured epiphysis of middle phalanx of manus" ; rdfs:subClassOf obo:HP_0010261, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041210 obo:IAO_0000115 "A partial or complete breakage of the lateral malleolus of fibula." ; oboInOwl:hasExactSynonym "bone lateral malleolus of fibula" ; a owl:Class ; rdfs:label "Fractured lateral malleolus of fibula" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0010595, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012291 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041211 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of digit 2." ; oboInOwl:hasExactSynonym "bone proximal phalanx of digit 2" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of digit 2" ; rdfs:subClassOf obo:HP_0041083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041212 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of digit 3." ; oboInOwl:hasExactSynonym "bone proximal phalanx of digit 3" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of digit 3" ; rdfs:subClassOf obo:HP_0041083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014503 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041213 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of digit 4." ; oboInOwl:hasExactSynonym "bone proximal phalanx of digit 4" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of digit 4" ; rdfs:subClassOf obo:HP_0041083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014504 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041214 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of digit 5." ; oboInOwl:hasExactSynonym "bone proximal phalanx of digit 5" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of digit 5" ; rdfs:subClassOf obo:HP_0041083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014505 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041215 obo:IAO_0000115 "A partial or complete breakage of the fused metatarsal bones 2-4." ; oboInOwl:hasExactSynonym "bone fused metatarsal bones 2-4" ; a owl:Class ; rdfs:label "Fractured fused metatarsal bones 2-4" ; rdfs:subClassOf obo:HP_0001832, obo:HP_0003084, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014763 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041216 obo:IAO_0000115 "A partial or complete breakage of the distal epiphysis of distal phalanx of manual digit 1." ; oboInOwl:hasExactSynonym "bone distal epiphysis of distal phalanx of manual digit 1" ; a owl:Class ; rdfs:label "Fractured distal epiphysis of distal phalanx of manual digit 1" ; rdfs:subClassOf obo:HP_0009679, obo:HP_0041147 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0014881 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041217 obo:IAO_0000115 "A fracture or multiple fractures of the humerus (ball) or the glenoid (socket) of the shoulder joint." ; oboInOwl:hasExactSynonym "bone shoulder joint" ; a owl:Class ; rdfs:label "Fractured shoulder" ; rdfs:subClassOf obo:HP_0003043, obo:HP_0009810, obo:HP_0020110 . obo:HP_0041218 obo:IAO_0000115 "A partial or complete breakage of the distal phalanx." ; oboInOwl:hasExactSynonym "bone distal phalanx" ; a owl:Class ; rdfs:label "Fractured distal phalanx" ; rdfs:subClassOf obo:HP_0041083 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041219 obo:IAO_0000115 "A partial or complete breakage of the elbow." ; oboInOwl:hasExactSynonym "bone elbow" ; a owl:Class ; rdfs:label "Fractured elbow" ; rdfs:subClassOf obo:HP_0009811, obo:HP_0041118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001461 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041220 obo:IAO_0000115 "A partial or complete breakage of the facial bone." ; oboInOwl:hasExactSynonym "bone facial bone" ; a owl:Class ; rdfs:label "Fractured facial bone" ; rdfs:subClassOf obo:HP_0011821, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003462 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041221 obo:IAO_0000115 "A partial or complete breakage of the head of femur." ; oboInOwl:hasExactSynonym "bone head of femur" ; a owl:Class ; rdfs:label "Fractured head of femur" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0003368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041222 obo:IAO_0000115 "A partial or complete breakage of the fibula." ; oboInOwl:hasExactSynonym "Broken fibula", "Fibula fracture", "Fracture of the fibula", "bone fibula" ; a owl:Class ; rdfs:label "Fractured fibula" ; rdfs:subClassOf obo:HP_0002991, obo:HP_0003084, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041223 obo:IAO_0000115 "A partial or complete breakage of the metatarsal bone of digit 5." ; oboInOwl:hasExactSynonym "bone metatarsal bone of digit 5" ; a owl:Class ; rdfs:label "Fractured metatarsal bone of digit 5" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0008089, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003654 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041224 obo:IAO_0000115 "A partial or complete breakage of the manual digit bone." ; oboInOwl:hasExactSynonym "bone manual digit bone" ; a owl:Class ; rdfs:label "Fractured manual digit bone" ; rdfs:subClassOf obo:HP_0004277, obo:HP_0011297, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004249 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041225 obo:IAO_0000115 "A partial or complete breakage of the metacarpal bone of digit 1." ; oboInOwl:hasExactSynonym "bone metacarpal bone of digit 1" ; a owl:Class ; rdfs:label "Fractured metacarpal bone of digit 1" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0004277, obo:HP_0005916, obo:HP_0010009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003645 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041226 obo:IAO_0000115 "A partial or complete breakage of the distal tarsal bone." ; oboInOwl:hasExactSynonym "bone distal tarsal bone" ; a owl:Class ; rdfs:label "Fractured distal tarsal bone" ; rdfs:subClassOf obo:HP_0041247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041227 obo:IAO_0000115 "A partial or complete breakage of the distal tarsal bone 2." ; oboInOwl:hasExactSynonym "bone distal tarsal bone 2" ; a owl:Class ; rdfs:label "Fractured distal tarsal bone 2" ; rdfs:subClassOf obo:HP_0041226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041228 obo:IAO_0000115 "A partial or complete breakage of the distal tarsal bone 3." ; oboInOwl:hasExactSynonym "bone distal tarsal bone 3" ; a owl:Class ; rdfs:label "Fractured distal tarsal bone 3" ; rdfs:subClassOf obo:HP_0041226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001454 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041230 obo:IAO_0000115 "A partial or complete breakage of the metatarsal bone of digit 4." ; oboInOwl:hasExactSynonym "bone metatarsal bone of digit 4" ; a owl:Class ; rdfs:label "Fractured metatarsal bone of digit 4" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0040035, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003653 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041231 obo:IAO_0000115 "A partial or complete breakage of the metatarsal bone of digit 1." ; oboInOwl:hasExactSynonym "bone metatarsal bone of digit 1" ; a owl:Class ; rdfs:label "Fractured metatarsal bone of digit 1" ; rdfs:subClassOf obo:HP_0003084, obo:HP_0010054, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041232 obo:IAO_0100001 "HP:0004277" ; a owl:Class ; rdfs:label "obsolete Fractured skeleton of manual acropodium" ; owl:deprecated true . obo:HP_0041233 obo:IAO_0000115 "A partial or complete breakage of the ilium." ; oboInOwl:hasExactSynonym "bone ilium" ; a owl:Class ; rdfs:label "Fractured ilium" ; rdfs:subClassOf obo:HP_0002867, obo:HP_0020110, obo:HP_0040163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041234 obo:IAO_0000115 "A partial or complete breakage of the bone of jaw." ; oboInOwl:hasExactSynonym "bone bone of jaw" ; a owl:Class ; rdfs:label "Fractured bone of jaw" ; rdfs:subClassOf obo:HP_0031816, obo:HP_0041220 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012360 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041235 obo:IAO_0000115 "A partial or complete breakage of the hindlimb bone." ; oboInOwl:hasExactSynonym "bone hindlimb bone" ; a owl:Class ; rdfs:label "Fractured hindlimb bone" ; rdfs:subClassOf obo:HP_0020110, obo:HP_0040069 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003464 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041236 obo:IAO_0000115 "A partial or complete breakage of the middle phalanx of manus." ; oboInOwl:hasExactSynonym "bone middle phalanx of manus" ; a owl:Class ; rdfs:label "Fractured middle phalanx of manus" ; rdfs:subClassOf obo:HP_0009833, obo:HP_0041241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041237 obo:IAO_0000115 "A partial or complete breakage of the patella." ; oboInOwl:hasExactSynonym "bone patella" ; a owl:Class ; rdfs:label "Fractured patella" ; rdfs:subClassOf obo:HP_0003045, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041239 obo:IAO_0000115 "A partial or complete breakage of the manual digit 1 phalanx." ; oboInOwl:hasExactSynonym "bone manual digit 1 phalanx" ; a owl:Class ; rdfs:label "Fractured manual digit 1 phalanx" ; rdfs:subClassOf obo:HP_0001172, obo:HP_0041241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041240 obo:IAO_0000115 "A partial or complete breakage of the phalanx of pes." ; oboInOwl:hasExactSynonym "bone phalanx of pes" ; a owl:Class ; rdfs:label "Fractured phalanx of pes" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0041083, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001449 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041241 obo:IAO_0000115 "A partial or complete breakage of the phalanx of manus." ; oboInOwl:hasExactSynonym "bone phalanx of manus" ; a owl:Class ; rdfs:label "Fractured phalanx of manus" ; rdfs:subClassOf obo:HP_0005918, obo:HP_0041083, obo:HP_0041224 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001436 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041243 obo:IAO_0000115 "A partial or complete breakage of the proximal phalanx of manus." ; oboInOwl:hasExactSynonym "bone proximal phalanx of manus" ; a owl:Class ; rdfs:label "Fractured proximal phalanx of manus" ; rdfs:subClassOf obo:HP_0009834, obo:HP_0041241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041244 obo:IAO_0000115 "A partial or complete breakage of the scapula." ; oboInOwl:hasExactSynonym "bone scapula" ; a owl:Class ; rdfs:label "Fractured scapula" ; rdfs:subClassOf obo:HP_0000782, obo:HP_0020110 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006849 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041245 obo:IAO_0000115 "A partial or complete breakage of a shoulder bone." ; oboInOwl:hasExactSynonym "bone shoulder bone" ; a owl:Class ; rdfs:comment "The shoulder is made up of three bones: the scapula, clavicle, and humerus." ; rdfs:label "Fractured shoulder bone" ; rdfs:subClassOf obo:HP_0020110, obo:HP_0040070 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003461 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041246 obo:IAO_0000115 "A partial or complete breakage of the sternum." ; oboInOwl:hasExactSynonym "bone sternum" ; a owl:Class ; rdfs:label "Fractured sternum" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041247 obo:IAO_0000115 "A partial or complete breakage of the tarsal bone." ; oboInOwl:hasExactSynonym "bone tarsal bone" ; a owl:Class ; rdfs:label "Fractured tarsal bone" ; rdfs:subClassOf obo:HP_0001850, obo:HP_0041235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041248 obo:IAO_0000115 "A partial or complete breakage of the carpal bone." ; oboInOwl:hasExactSynonym "Broken wrist", "Carpal bone fracture", "Fractured wrist", "Wrist fracture", "bone carpal bone" ; a owl:Class ; rdfs:label "Fractured carpal bone" ; rdfs:subClassOf obo:HP_0001191, obo:HP_0004277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0041249 obo:IAO_0000115 "A partial or complete breakage of the nose." ; oboInOwl:hasExactSynonym "bone nose" ; a owl:Class ; rdfs:label "Fractured nose" ; rdfs:subClassOf obo:HP_0005105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040034 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045001 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022409" ; a owl:Class ; rdfs:label "Abnormal ossification of the trapezium" ; rdfs:subClassOf obo:HP_0004252, obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001430 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045002 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022408" ; a owl:Class ; rdfs:label "Absent ossification of the trapezium" ; rdfs:subClassOf obo:HP_0045001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001430 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045003 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022407" ; a owl:Class ; rdfs:label "Abnormal ossification of the scaphoid" ; rdfs:subClassOf obo:HP_0004243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001427 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045004 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022406" ; a owl:Class ; rdfs:label "Abnormal ossification of the trapezoid bone" ; rdfs:subClassOf obo:HP_0004256, obo:HP_0006257 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001431 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045005 obo:IAO_0000115 "A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:D009436", "SNOMEDCT_US:253098009", "UMLS:C0027794" ; oboInOwl:hasExactSynonym "Abnormality of neural tube closure" ; a owl:Class ; rdfs:label "Neural tube defect" ; rdfs:subClassOf obo:HP_0410043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0001843 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045006 obo:IAO_0000115 "Aplasia (absence) of the lymphatic vessels." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022404" ; oboInOwl:hasExactSynonym "Absent lymphatic vessels" ; a owl:Class ; rdfs:label "Aplasia of lymphatic vessels" ; rdfs:subClassOf obo:HP_0100766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045007 obo:IAO_0000115 "A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022403" ; oboInOwl:hasExactSynonym "Abnormality of the substantia nigra" ; a owl:Class ; rdfs:label "Abnormal substantia nigra morphology" ; rdfs:subClassOf obo:HP_0002134, obo:HP_0002418 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002038 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045008 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022402" ; a owl:Class ; rdfs:label "Abnormal shape of the radius" ; rdfs:subClassOf obo:HP_0002818 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045009 obo:IAO_0100001 "HP:0002818" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Abnormal morphology of the radius" ; owl:deprecated true . obo:HP_0045010 obo:IAO_0000115 "Abnormal morphology of a specific peripheral nerve" ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022400" ; a owl:Class ; rdfs:label "Abnormal peripheral nerve morphology by anatomical site" ; rdfs:subClassOf obo:HP_0000759 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001021 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045011 obo:IAO_0000115 "Abnormally decreased concentration of hydrogencarbonate in the urine." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022399" ; oboInOwl:hasExactSynonym "Decreased urine HCO3 concentration" ; a owl:Class ; rdfs:label "Decreased urine bicarbonate concentration" ; rdfs:subClassOf obo:HP_0011279 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045012 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022398" ; a owl:Class ; rdfs:label "Decreased urinary catecholamine concentration" ; rdfs:subClassOf obo:HP_0011281 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33567 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045013 a owl:Class ; rdfs:label "obsolete Decreased urinary glucose concentration" ; owl:deprecated true . obo:HP_0045014 dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:238090007", "UMLS:C0342892" ; a owl:Class ; rdfs:label "Hypolipidemia" ; rdfs:subClassOf obo:HP_0003119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18059 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045016 obo:IAO_0100001 "HP:0003455" ; oboInOwl:hasExactSynonym "Increased serum long-chain fatty acids" ; a owl:Class ; rdfs:label "obsolete Elevated serum long-chain fatty acids" ; owl:deprecated true . obo:HP_0045017 obo:IAO_0000115 "Defect or defects of the morphogenesis of the left heart identifiable at birth." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022397" ; a owl:Class ; rdfs:label "Congenital malformation of the left heart" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_0045018 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022396" ; oboInOwl:hasExactSynonym "Partial double eyebrow", "Partial duplication of eyebrows" ; a owl:Class ; rdfs:label "Partial duplication of eyebrows" ; rdfs:subClassOf obo:HP_0010730 . obo:HP_0045025 obo:IAO_0000115 "Reduction in the vertical distance between the upper and lower eyelids." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C1837464", "UMLS:C2675021" ; oboInOwl:hasExactSynonym "Narrow palpebral fissures", "Small opening between the eyelids", "Small palpebral fissures" ; oboInOwl:hasNarrowSynonym "Decreased size of palpebral fissure" ; oboInOwl:hasRelatedSynonym "Narrow eyelid opening" ; a owl:Class ; rdfs:label "Narrow palpebral fissure" ; rdfs:subClassOf obo:HP_0200007 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000599 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045026 obo:IAO_0000115 "Any structural anomaly of the central compartment of the thoracic cavity." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0100722" ; oboInOwl:hasDbXref "UMLS:C4022395" ; oboInOwl:hasExactSynonym "Abnormality of the mediastinum" ; a owl:Class ; rdfs:label "Abnormal mediastinum morphology" ; rdfs:subClassOf obo:HP_0045027 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003728 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045027 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022394" ; a owl:Class ; rdfs:label "Abnormality of the thoracic cavity" ; rdfs:subClassOf obo:HP_0000118 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002224 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045028 obo:IAO_0000115 "Severe microcephaly and lissencephaly with granular surfaces with immature cortical plate, reduced in thickness, with focal polymicrogyria and immature small neurons with rare processes, intermingled with a considerable number of glial elements." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021030" ; oboInOwl:hasExactSynonym "Lissencephaly type III", "Type 3 lissencephaly", "Type III lissencephaly" ; a owl:Class ; rdfs:comment "This is a severe phenotype that can be diagnosed at the fetopathological level, by which a diagnosis of lissencephaly can be made by the examination of the 6 layers of the cortex. Examination may show 3 layers or an extremely thin cortical plate consistent with the diagnosis of lissencephaly." ; rdfs:label "Microlissencephaly" ; rdfs:subClassOf obo:HP_0001339 . obo:HP_0045029 obo:IAO_0000115 "Inflammation and thickening (localized fibrosis) of the fascia, the tissue under the skin and over the muscle, typically associated with a build up of eosinophils in the muscles and tissues." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:C562487", "SNOMEDCT_US:24129002", "UMLS:C0264005" ; a owl:Class ; rdfs:label "Eosinophilic fasciitis" ; rdfs:subClassOf obo:HP_0100537 . obo:HP_0045034 obo:IAO_0000115 "An increased amount of 3-aminoisobutyric acid in the urine." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4022393" ; a owl:Class ; rdfs:label "Elevated urinary aminoisobutyric acid" ; rdfs:subClassOf obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27389 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045035 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073164" ; oboInOwl:hasExactSynonym "Decreased urinary copper concentration" ; a owl:Class ; rdfs:label "Decreased urinary copper concentration" ; rdfs:subClassOf obo:HP_0045036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045036 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073165" ; oboInOwl:hasExactSynonym "Abnormal urinary copper concentration" ; a owl:Class ; rdfs:label "Abnormal urinary copper concentration" ; rdfs:subClassOf obo:HP_0025640 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28694 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045037 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073166" ; oboInOwl:hasExactSynonym "Abnormality of jaw muscles" ; a owl:Class ; rdfs:label "Abnormality of jaw muscles" ; rdfs:subClassOf obo:HP_0000301 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011648 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045038 obo:IAO_0000115 "Lymphoma that originates in the stomach itself." ; dcterms:creator ; oboInOwl:hasDbXref "MSH:C535648", "SNOMEDCT_US:276811008", "UMLS:C0349532" ; oboInOwl:hasExactSynonym "Primary gastric lymphoma" ; a owl:Class ; rdfs:comment "An uncommon condition, that accounts for less than 15% of gastric malignancies and about 2% of all lymphomas." ; rdfs:label "Gastric lymphoma" ; rdfs:subClassOf obo:HP_0002665, obo:HP_0006753 . obo:HP_0045039 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073167" ; a owl:Class ; rdfs:label "Osteolysis involving bones of the upper limbs" ; rdfs:subClassOf obo:HP_0002797, obo:HP_0040070 . obo:HP_0045040 obo:IAO_0000115 "A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate." ; oboInOwl:hasDbXref "UMLS:C4073168" ; a owl:Class ; rdfs:label "Abnormal lactate dehydrogenase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0045041 obo:IAO_0000115 "A decreased or reduced level of the enzyme lactate dehydrogenase in serum." ; oboInOwl:hasDbXref "MSH:C563641", "UMLS:C3279904" ; a owl:Class ; rdfs:comment "Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate. The B subunit of that enzyme is encoded by LDHB." ; rdfs:label "Reduced lactate dehydrogenase B level" ; rdfs:subClassOf obo:HP_0045040 . obo:HP_0045042 obo:IAO_0000115 "Concentration of the complement component C4 in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073169" ; oboInOwl:hasExactSynonym "Decreased serum complement C4", "Decreased serum complement C4 level" ; a owl:Class ; rdfs:label "Decreased circulating complement C4 concentration" ; rdfs:subClassOf obo:HP_0004431 . obo:HP_0045043 obo:IAO_0000115 "Concentration of the complement component C4a in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073170" ; oboInOwl:hasExactSynonym "C4a deficiency", "Complement component 4A deficiency", "Decreased serum complement C4a" ; a owl:Class ; rdfs:label "Decreased circulating complement C4a concentration" ; rdfs:subClassOf obo:HP_0045042 . obo:HP_0045044 obo:IAO_0000115 "Concentration of the complement component C4b in the blood circulation below the lower limit of normal." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C3280641" ; oboInOwl:hasExactSynonym "C4b deficiency", "Complement component 4B deficiency" ; a owl:Class ; rdfs:label "Decreased circulating complement C4b concentration" ; rdfs:subClassOf obo:HP_0045042 . obo:HP_0045045 obo:IAO_0000115 "An abnormally increased concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073171" ; oboInOwl:hasExactSynonym "Elevated plasma acylcarnitine levels" ; a owl:Class ; rdfs:label "Elevated circulating acylcarnitine concentration" ; rdfs:subClassOf obo:HP_0012071 . obo:HP_0045046 obo:IAO_0000115 "An abnormally decreased concentration of insulin like growth factor binding protein acid labile subunit level in the blood circulation." ; oboInOwl:hasDbXref "UMLS:C3900122" ; oboInOwl:hasExactSynonym "Acid-labile subunit deficiency", "Decreased levels of acid labile subunit", "Reduced insulin like growth factor binding protein acid labile subunit level" ; a owl:Class ; rdfs:comment "Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene." ; rdfs:label "Reduced insulin like growth factor binding protein acid labile subunit concentration" ; rdfs:subClassOf obo:HP_0031034 . obo:HP_0045047 obo:IAO_0000115 "Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography." ; oboInOwl:hasDbXref "MSH:D006451", "SNOMEDCT_US:50095005", "UMLS:C0019043" ; oboInOwl:hasExactSynonym "HbS haemoglobin" ; a owl:Class ; rdfs:label "HbS hemoglobin" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0045048 obo:IAO_0000115 "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia." ; oboInOwl:hasDbXref "UMLS:C4073172" ; oboInOwl:hasExactSynonym "Increased HbA2 haemoglobin", "Increased haemoglobin A2", "Increased hemoglobin A2" ; a owl:Class ; rdfs:label "Increased HbA2 hemoglobin" ; rdfs:subClassOf obo:HP_0011902 . obo:HP_0045049 obo:IAO_0000115 "An abnormal amount of oxygen passes into the blood from the lungs and/or an abnormal amount of carbon dioxide passes from the blood into the lungs." ; oboInOwl:hasDbXref "UMLS:C4073173" ; oboInOwl:hasExactSynonym "Abnormal TLCO", "Abnormal diffusing capacity", "Abnormal transfer factor of the lung for carbon monoxide" ; a owl:Class ; rdfs:comment "Inhaled CO is used for this test due to its high affinity for hemoglobin (200-250 times that of oxygen). During a ten-second breath-hold, DLCO measures uptake of CO per unit time per mm of driving pressure of CO (cc of CO/sec/mm of Hg)." ; rdfs:label "Abnormal DLCO" ; rdfs:subClassOf obo:HP_0030878 . obo:HP_0045050 obo:IAO_0000115 "Increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test." ; oboInOwl:hasDbXref "UMLS:C4073174" ; oboInOwl:hasExactSynonym "Increased diffusing capacity" ; a owl:Class ; rdfs:comment "Factors that can increase the DLCO include polycythaemia, asthma (can also have normal DLCO) and increased pulmonary blood volume as occurs in exercise. Other factors are left to right intracardiac shunting, and alveolar hemorrhage." ; rdfs:label "Increased DLCO" ; rdfs:subClassOf obo:HP_0045049 . obo:HP_0045051 obo:IAO_0000115 "Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test." ; oboInOwl:hasDbXref "UMLS:C4073175" ; oboInOwl:hasExactSynonym "Decreased diffusing capacity" ; a owl:Class ; rdfs:comment "DLCO is decreased in any condition which affects the effective alveolar surface area" ; rdfs:label "Decreased DLCO" ; rdfs:subClassOf obo:HP_0045049 . obo:HP_0045052 obo:IAO_0000115 "Any abnormality of the brachial nerve plexus." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073176" ; a owl:Class ; rdfs:label "Abnormality of the brachial nerve plexus" ; rdfs:subClassOf obo:HP_0410010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001814 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045053 obo:IAO_0000115 "Any abnormality of the lumbosacral nerve plexus." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4073177" ; a owl:Class ; rdfs:label "Abnormality of the lumbosacral nerve plexus" ; rdfs:subClassOf obo:HP_0410010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001815 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045054 dcterms:creator ; oboInOwl:hasDbXref "MSH:D020516", "SNOMEDCT_US:3548001", "UMLS:C0700251" ; a owl:Class ; rdfs:comment "Related to ticket: https://github.com/obophenotype/human-phenotype-ontology/issues/484" ; rdfs:label "Brachial plexus neuropathy" ; rdfs:subClassOf obo:HP_0045052 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001167 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001814 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045055 obo:IAO_0000115 "An abnormal appearance of hair under polarizing microscopy (using crossed polarizers), whereby hair shafts show striking alternating bright and dark bands, often referred to as tiger tail banding." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032461" ; oboInOwl:hasDbXref "UMLS:C4073178" ; oboInOwl:hasExactSynonym "Tiger tail banding", "Tiger-tail banding" ; a owl:Class ; rdfs:label "Tiger tail banding" ; rdfs:subClassOf obo:HP_0003328 . obo:HP_0045056 obo:IAO_0000115 "Concentration of alpha-fetoprotein in the blood circulation outside normal limits." ; oboInOwl:hasDbXref "UMLS:C4073179" ; a owl:Class ; rdfs:label "Abnormal circulating alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003809 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045057 obo:IAO_0000115 "Concentration of alpha-fetoprotein in the blood circulation below the lower limit of normal." ; oboInOwl:hasDbXref "UMLS:C4073295" ; a owl:Class ; rdfs:label "Decreased circulating alpha-fetoprotein concentration" ; rdfs:subClassOf obo:HP_0045056 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003809 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045058 obo:IAO_0000115 "An anomaly of the size of the testicle (the male gonad)." ; oboInOwl:hasDbXref "UMLS:C4073180" ; a owl:Class ; rdfs:label "Abnormality of the testis size" ; rdfs:subClassOf obo:HP_0000035 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045059 obo:IAO_0000115 "A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point that is composed of localized hyperkeratosis (the latter may be demonstrated histopathologically)." ; oboInOwl:hasDbXref "UMLS:C2047516" ; a owl:Class ; rdfs:label "Hyperkeratotic papule" ; rdfs:subClassOf obo:HP_0000962, obo:HP_0200034 . obo:HP_0045060 oboInOwl:hasDbXref "UMLS:C4073181" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia involving bones of the extremities" ; rdfs:subClassOf obo:HP_0002813, obo:HP_0009815 . obo:HP_0045061 oboInOwl:hasDbXref "UMLS:C4073182" ; a owl:Class ; rdfs:label "Decreased carnitine level in liver" ; rdfs:subClassOf obo:HP_0032243, obo:HP_0034644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045063 obo:IAO_0000115 "Des-gamma carboxyprothrombin (DCP) or pro-thrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of patients with HCC. Generation of DCP is thought to be a result of an acquired defect in the post- translational carboxylation of the prothrombin precursor in malignant cells." ; oboInOwl:hasDbXref "UMLS:C1112467" ; oboInOwl:hasExactSynonym "Increased prothrombin induced by vitamin K absence-II" ; a owl:Class ; rdfs:comment "PIVKA-II can be measured by enzyme-linked immunosorbent assay (ELISA)." ; rdfs:label "Increased PIVKA-II" ; rdfs:subClassOf obo:HP_0100831 . obo:HP_0045073 obo:IAO_0000115 "Inflammation in any serous cavity." ; a owl:Class ; rdfs:label "Serositis" ; rdfs:subClassOf obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000042 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045074 obo:IAO_0000115 "Decreased diameter of eyebrow hairs." ; dcterms:creator ; oboInOwl:hasExactSynonym "Thin eyebrow", "Thin eyebrows" ; a owl:Class ; rdfs:label "Thin eyebrow" ; rdfs:subClassOf obo:HP_0100840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045075 obo:IAO_0000115 "Decreased density/number of eyebrow hairs." ; oboInOwl:hasAlternativeId "HP:0000535", "HP:0002222", "HP:0002554", "HP:0004520", "HP:0004551" ; oboInOwl:hasExactSynonym "Hypotrichosis of eyebrow", "Sparse eyebrow", "Sparse eyebrows" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Sparseness can be regional (medial, central, lateral) or total." ; rdfs:label "Sparse eyebrow" ; rdfs:subClassOf obo:HP_0100840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045079 obo:IAO_0000115 "Irregularity of the normally smooth surface of the distal metaphysis of the femur." ; dcterms:creator ; oboInOwl:hasExactSynonym "Irregular distal femoral metaphyses" ; a owl:Class ; rdfs:label "Distal femoral metaphyseal irregularity" ; rdfs:subClassOf obo:HP_0030291 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006864 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045080 obo:IAO_0000115 "Any abnormality in the proportion of CD3-positive T cells relative to the total number of T cells." ; oboInOwl:hasAlternativeId "HP:0045072" ; oboInOwl:hasExactSynonym "Decreased proportion of CD3+ T cells" ; a owl:Class ; rdfs:label "Decreased proportion of CD3-positive T cells" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0045081 obo:IAO_0000115 "Anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages." ; oboInOwl:hasExactSynonym "Abnormal BMI", "Abnormal body mass index" ; a owl:Class ; rdfs:label "Abnormality of body mass index" ; rdfs:subClassOf obo:HP_0004323 . obo:HP_0045082 obo:IAO_0000115 "Abnormally decreased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of underweight compared to averages." ; oboInOwl:hasExactSynonym "Decreased BMI" ; a owl:Class ; rdfs:label "Decreased body mass index" ; rdfs:subClassOf obo:HP_0004325, obo:HP_0045081 . obo:HP_0045083 oboInOwl:consider "HP:0004324" ; a owl:Class ; rdfs:label "obsolete Increased body mass index" ; owl:deprecated true . obo:HP_0045084 oboInOwl:hasExactSynonym "Myoclonus of limbs" ; a owl:Class ; rdfs:comment "Limb myoclonus was noted in Early myoclonic encephalopathy. See PMID:27789573" ; rdfs:label "Limb myoclonus" ; rdfs:subClassOf obo:HP_0001336 . obo:HP_0045085 oboInOwl:hasExactSynonym "Atrophied masseter muscle", "Masseter muscle atrophy" ; a owl:Class ; rdfs:label "Atrophy of masseter muscle" ; rdfs:subClassOf obo:HP_3000005 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045086 obo:IAO_0000115 "The ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees)." ; oboInOwl:hasExactSynonym "Knee joint over-flexibility" ; a owl:Class ; rdfs:label "Knee joint hypermobility" ; rdfs:subClassOf obo:HP_0001382, obo:HP_0010500 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001485 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045087 a owl:Class ; rdfs:label "Hip joint hypermobility" ; rdfs:subClassOf obo:HP_0001382, obo:HP_0001384 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002282 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001486 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0045088 obo:IAO_0000115 "Subontology for annotating phenotypic features as distinctive or minor findings in patients. The subontology is intended to be used to annotate subjective clinical impressions of whether a certain finding is important for the differential diagnosis." ; dcterms:creator ; a owl:Class ; rdfs:label "Clinical relevance" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0045089 obo:IAO_0000115 "In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is likely to have high utility in distinguishing the correct diagnosis from other candidates in the differential." ; dcterms:creator ; a owl:Class ; rdfs:label "Distinctive finding" ; rdfs:subClassOf obo:HP_0045088 . obo:HP_0045090 obo:IAO_0000115 "In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is unlikely to help distinguish the correct diagnosis from other candidates in the differential." ; dcterms:creator ; a owl:Class ; rdfs:label "Minor finding" ; rdfs:subClassOf obo:HP_0045088 . obo:HP_0046502 obo:IAO_0000115 "Inability of individual to reach orgasm." ; dcterms:creator ; a owl:Class ; rdfs:label "Anorgasmia" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0046503 obo:IAO_0000115 "Elevated sexual desire." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased libido" ; rdfs:subClassOf obo:HP_0031845 . obo:HP_0046504 obo:IAO_0000115 "Decreased sexual desire." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased libido" ; rdfs:subClassOf obo:HP_0031845 . obo:HP_0046505 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort localized to the hand." ; dcterms:creator ; a owl:Class ; rdfs:label "Hand pain" ; rdfs:subClassOf obo:HP_0012513 . obo:HP_0046506 dcterms:creator ; a owl:Class ; rdfs:label "Pain in head and neck region" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0046507 obo:IAO_0000115 "Bradypnea is referring to breathing that is abnormally slow." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMED_CT:86684002" ; a owl:Class ; rdfs:label "Bradypnea" ; rdfs:subClassOf obo:HP_0002793 . obo:HP_0046508 obo:IAO_0000115 "Any morphological abnormality of the cervical vertebral column." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMED_CT:298391004" ; a owl:Class ; rdfs:label "Abnormal cervical spine morphology" ; rdfs:subClassOf obo:HP_0003319, obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100000 obo:IAO_0000115 "An early onset of puberty, in this case early does not refer to precocious." ; dcterms:creator ; oboInOwl:creation_date "2010-05-04T10:35:02Z" ; oboInOwl:hasDbXref "UMLS:C4022392" ; oboInOwl:hasExactSynonym "Early onset of sexual maturation" ; oboInOwl:id "HP:0100000" ; a owl:Class ; rdfs:label "Early onset of sexual maturation" ; rdfs:subClassOf obo:HP_0008373 . obo:HP_0100001 obo:IAO_0000115 "Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer." ; dcterms:creator ; oboInOwl:creation_date "2010-05-11T04:10:29Z" ; oboInOwl:hasDbXref "MSH:C562839", "SNOMEDCT_US:62064005", "UMLS:C0345967" ; oboInOwl:id "HP:0100001" ; a owl:Class ; rdfs:label "Malignant mesothelioma" ; rdfs:subClassOf obo:HP_0011793 . obo:HP_0100002 obo:IAO_0000115 "A malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma." ; dcterms:creator ; oboInOwl:creation_date "2010-05-11T04:16:23Z" ; oboInOwl:hasDbXref "NCIT:C3234", "SNOMEDCT_US:254645002", "UMLS:C0812413" ; oboInOwl:id "HP:0100002" ; a owl:Class ; rdfs:label "Pleural mesothelioma" ; rdfs:subClassOf obo:HP_0100001, obo:HP_0100527 . obo:HP_0100003 obo:IAO_0000115 "A Malignant mesothelioma originating from cells of the peritoneum (the thin layer of mesothelium lining the abdomen). Peritoneal mesothelioma is the second most common form of mesothelioma after pleural mesothelioma." ; dcterms:creator ; oboInOwl:creation_date "2010-05-11T04:16:23Z" ; oboInOwl:hasDbXref "NCIT:C3234", "SNOMEDCT_US:109853004", "UMLS:C0346109" ; oboInOwl:id "HP:0100003" ; a owl:Class ; rdfs:label "Peritoneal mesothelioma" ; rdfs:subClassOf obo:HP_0002585, obo:HP_0100001, obo:HP_0100016 . obo:HP_0100004 obo:IAO_0000115 "A Malignant mesothelioma originating from cells of the pericardium (the thin layer of mesothelium lining the heart)." ; dcterms:creator ; oboInOwl:creation_date "2010-05-11T04:16:23Z" ; oboInOwl:hasDbXref "NCIT:C3234", "UMLS:C1335381" ; oboInOwl:id "HP:0100004" ; a owl:Class ; rdfs:label "Pericardial mesothelioma" ; rdfs:subClassOf obo:HP_0001697, obo:HP_0100001 . obo:HP_0100005 obo:IAO_0000115 "A Malignant mesothelioma of the testis." ; dcterms:creator ; oboInOwl:creation_date "2010-05-11T04:16:23Z" ; oboInOwl:hasDbXref "NCIT:C3234", "UMLS:C4022391" ; oboInOwl:id "HP:0100005" ; a owl:Class ; rdfs:comment "Testicular mesothelioma originates from cells of the tunica vaginalis (the thin layer of mesothelium surrounding the testicles). Testicular mesothelioma is the rarest form of mesothelioma." ; rdfs:label "Testicular mesothelioma" ; rdfs:subClassOf obo:HP_0010788, obo:HP_0100001 . obo:HP_0100006 obo:IAO_0000115 "A neoplasm of the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:11:53Z" ; oboInOwl:hasDbXref "MSH:D016543", "NCIT:C3262", "SNOMEDCT_US:126951006", "UMLS:C0085136" ; oboInOwl:hasExactSynonym "Neoplasm of the CNS", "Tumors of the central nervous system", "Tumours of the central nervous system" ; oboInOwl:hasRelatedSynonym "Neoplasia of the central nervous system" ; oboInOwl:id "HP:0100006" ; a owl:Class ; rdfs:label "Neoplasm of the central nervous system" ; rdfs:subClassOf obo:HP_0002011, obo:HP_0004375 . obo:HP_0100007 obo:IAO_0000115 "A benign or malignant neoplasm (tumor) of the peripheral nervous system." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:11:53Z" ; oboInOwl:hasDbXref "MSH:D010524", "NCIT:C3262", "SNOMEDCT_US:126980002", "UMLS:C0031118" ; oboInOwl:hasExactSynonym "Tumor of the peripheral nervous system", "Tumour of the peripheral nervous system" ; oboInOwl:id "HP:0100007" ; a owl:Class ; rdfs:label "Neoplasm of the peripheral nervous system" ; rdfs:subClassOf obo:HP_0000759, obo:HP_0004375 . obo:HP_0100008 obo:IAO_0000115 "A benign nerve sheath tumor composed of Schwann cells." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:13:07Z" ; oboInOwl:hasDbXref "MSH:D009442", "SNOMEDCT_US:404022001", "SNOMEDCT_US:985004", "UMLS:C0027809" ; oboInOwl:hasExactSynonym "Neurilemmoma", "Neurinoma", "Neurolemmoma", "Schwann cell tumor", "Schwann cell tumour" ; oboInOwl:hasRelatedSynonym "Schwannomas" ; oboInOwl:id "HP:0100008" ; a owl:Class ; rdfs:comment "Glial cells are cells that support nerve cells. Schwann cells wrap around the axon to form the myelin sheath. Schwann cells are involved in many important aspects of peripheral nerve biology; the conduction of nervous impulses along axons, nerve development and regeneration, trophic support for neurons, production of the nerve extracellular matrix and presentation of antigens to T-lymphocytes. Charcot-Marie-Tooth disease (CMT), Guillain-Barre syndrome (GBS), schwannomatosis and chronic inflammatory demyelinating polyneuropathy (CIDP) are all neuropathies involving Schwann cells." ; rdfs:label "Schwannoma" ; rdfs:subClassOf obo:HP_0100007 . obo:HP_0100009 dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:29:27Z" ; oboInOwl:hasDbXref "MSH:D008579", "SNOMEDCT_US:302820008", "UMLS:C0349604" ; oboInOwl:id "HP:0100009" ; a owl:Class ; rdfs:label "Intracranial meningioma" ; rdfs:subClassOf obo:HP_0002858 . obo:HP_0100010 dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:29:27Z" ; oboInOwl:hasDbXref "MSH:D008579", "NCIT:C3230", "SNOMEDCT_US:189167009", "UMLS:C0347515" ; oboInOwl:id "HP:0100010" ; a owl:Class ; rdfs:label "Spinal meningioma" ; rdfs:subClassOf obo:HP_0002858 . obo:HP_0100011 dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:41:55Z" ; oboInOwl:hasDbXref "NCIT:C3269", "UMLS:C4022390" ; oboInOwl:id "HP:0100011" ; a owl:Class ; rdfs:label "Scleral schwannoma" ; rdfs:subClassOf obo:HP_0000591, obo:HP_0100008, obo:HP_0100012 . obo:HP_0100012 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the eye." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:43:34Z" ; oboInOwl:hasDbXref "MSH:D005134", "NCIT:C3262", "SNOMEDCT_US:371486001", "UMLS:C0015414" ; oboInOwl:hasExactSynonym "Eye tumor", "Eye tumour" ; oboInOwl:hasRelatedSynonym "Neoplasia of the eye" ; oboInOwl:id "HP:0100012" ; a owl:Class ; rdfs:label "Neoplasm of the eye" ; rdfs:subClassOf obo:HP_0011793, obo:HP_0012372 . obo:HP_0100013 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the breast." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:45:09Z" ; oboInOwl:hasAlternativeId "HP:0010623" ; oboInOwl:hasDbXref "MSH:D001943", "NCIT:C3262", "SNOMEDCT_US:126926005", "UMLS:C1458155" ; oboInOwl:hasExactSynonym "Breast tumor", "Breast tumour", "Tumours of the breast" ; oboInOwl:hasRelatedSynonym "Neoplasia of the breast" ; oboInOwl:id "HP:0100013" ; a owl:Class ; rdfs:label "Neoplasm of the breast" ; rdfs:subClassOf obo:HP_0011793, obo:HP_0031093 . obo:HP_0100014 obo:IAO_0000115 "An epiretinal membrane is a thin sheet of fibrous tissue that can develop on the surface of the macular area of the retina and cause a disturbance in vision. An epiretinal membrane area can develop on the thin macular area of the retin. An epiretinal membrane is also sometimes called a macular pucker, premacular fibrosis, surface wrinkling retinopathy or cellophane maculopathy." ; dcterms:creator ; oboInOwl:creation_date "2010-05-14T09:53:27Z" ; oboInOwl:hasDbXref "MSH:D019773", "SNOMEDCT_US:133853005", "SNOMEDCT_US:367649002", "UMLS:C0339543" ; oboInOwl:hasExactSynonym "Macular pucker", "Premacular fibrosis" ; oboInOwl:hasRelatedSynonym "Epiretinal membranes" ; oboInOwl:id "HP:0100014" ; a owl:Class ; rdfs:label "Epiretinal membrane" ; rdfs:subClassOf obo:HP_0030498 . obo:HP_0100015 obo:IAO_0000115 "The presence of a supernumerary, i.e. third, crus of the helix in the helix, arising at or above the normal bifurcation of the antihelix." ; dcterms:creator ; oboInOwl:creation_date "2010-05-25T10:30:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253252004", "UMLS:C1862689" ; oboInOwl:hasExactSynonym "Additional crus", "Third crus" ; oboInOwl:id "HP:0100015" ; a owl:Class ; rdfs:comment "The helix is often poorly formed. Four types have been recognized in the surgical literature [Yamada and Fukuda, 1980]." ; rdfs:label "Stahl ear" ; rdfs:subClassOf obo:HP_0011235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004106 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002488 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100016 obo:IAO_0000115 "Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium)." ; dcterms:creator ; oboInOwl:creation_date "2010-05-25T11:20:36Z" ; oboInOwl:hasDbXref "UMLS:C4022389" ; oboInOwl:hasRelatedSynonym "Abnormality of the mesentery" ; oboInOwl:id "HP:0100016" ; a owl:Class ; rdfs:label "Abnormality of mesentery morphology" ; rdfs:subClassOf obo:HP_0002012 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002095 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100017 obo:IAO_0000115 "A cataract that affects the capsule of the lens." ; dcterms:creator ; oboInOwl:creation_date "2010-05-27T06:01:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204125003", "UMLS:C0339352" ; oboInOwl:id "HP:0100017" ; a owl:Class ; rdfs:label "Capsular cataract" ; rdfs:subClassOf obo:HP_0000518 . obo:HP_0100018 obo:IAO_0000115 "A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T11:34:45Z" ; oboInOwl:hasAlternativeId "HP:0007672", "HP:0007781", "HP:0008024" ; oboInOwl:hasDbXref "SNOMEDCT_US:53889007", "UMLS:C0392557" ; oboInOwl:hasExactSynonym "Yellowish cloudy center of lens", "Yellowish cloudy centre of lens" ; oboInOwl:id "HP:0100018" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Nuclear cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0100019 obo:IAO_0000115 "A cataract which affects the layer of the lens surrounding the nucleus, i.e., the lens cortex. It is identified by its unique wedge or spoke appearance." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T11:35:33Z" ; oboInOwl:hasAlternativeId "HP:0007876" ; oboInOwl:hasDbXref "SNOMEDCT_US:193576003", "UMLS:C0271160" ; oboInOwl:id "HP:0100019" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Cortical cataract" ; rdfs:subClassOf obo:HP_0010920 . obo:HP_0100020 obo:IAO_0000115 "A cataract which is found in the back outer layer of the lens. This type often develops more rapidly." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T11:36:49Z" ; oboInOwl:hasDbXref "UMLS:C4022388" ; oboInOwl:id "HP:0100020" ; a owl:Class ; rdfs:label "Posterior capsular cataract" ; rdfs:subClassOf obo:HP_0100017 . obo:HP_0100021 obo:IAO_0000115 "Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behaviour, by epilepsy, and by secondary musculoskeletal problems." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T11:46:16Z" ; oboInOwl:hasDbXref "MSH:D002547", "SNOMEDCT_US:128188000", "UMLS:C0007789" ; oboInOwl:hasExactSynonym "CP", "Cerebral paralysis" ; oboInOwl:id "HP:0100021" ; a owl:Class ; rdfs:label "Cerebral palsy" ; rdfs:subClassOf obo:HP_0011442, obo:HP_0100022 . obo:HP_0100022 obo:IAO_0000115 "An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T11:48:50Z" ; oboInOwl:hasAlternativeId "HP:0001294" ; oboInOwl:hasDbXref "MSH:D009069", "SNOMEDCT_US:60342002", "UMLS:C0026650" ; oboInOwl:hasExactSynonym "Abnormality of movement", "Movement disorder", "Unusual movement" ; oboInOwl:id "HP:0100022" ; a owl:Class ; rdfs:comment "Movement disorders are characterized by the phenotypic abnormalities including abnormal involuntary movements, akathisia, akinesia, athetosis, ataxia, ballismus, bradykinesia, chorea, dyskinesia, dystonia, and myoclonus tics, tremor, spasms, and stereotypy." ; rdfs:label "Abnormality of movement" ; rdfs:subClassOf obo:HP_0012638 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100023 obo:IAO_0000115 "A type of repetitive behavior in which the affected individual repeatedly waves the hands and/or arms rhythmically." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T12:10:09Z" ; oboInOwl:hasDbXref "UMLS:C4022387" ; oboInOwl:id "HP:0100023" ; a owl:Class ; rdfs:label "Recurrent hand flapping" ; rdfs:subClassOf obo:HP_5200018 . obo:HP_0100024 obo:IAO_0000115 "An unusually happy aspect over time which can also may be observed during inappropriate situations that should be causing for example distress, fear or anger." ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T05:32:35Z" ; oboInOwl:hasDbXref "UMLS:C4021029" ; oboInOwl:hasExactSynonym "Conspicious happy aspect", "Happy aspect" ; oboInOwl:id "HP:0100024" ; a owl:Class ; rdfs:label "Conspicuously happy disposition" ; rdfs:subClassOf obo:HP_0100851 . obo:HP_0100025 obo:IAO_0000115 "A form of hypersociability that presents as mostly inappropriate people-orientation and friendliness towards others on an inadequate level which might go as far as being dangerous considering for example young children following strangers without restriction." ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:creation_date "2010-05-28T05:42:06Z" ; oboInOwl:hasDbXref "UMLS:C4022386" ; oboInOwl:id "HP:0100025" ; a owl:Class ; rdfs:label "Overfriendliness" ; rdfs:subClassOf obo:HP_5200029 . obo:HP_0100026 obo:IAO_0000115 "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries." ; dcterms:creator ; oboInOwl:creation_date "2010-05-31T05:32:31Z" ; oboInOwl:hasDbXref "MSH:D001165", "SNOMEDCT_US:234141001", "SNOMEDCT_US:24551003", "UMLS:C0003857" ; oboInOwl:id "HP:0100026" ; a owl:Class ; rdfs:label "Arteriovenous malformation" ; rdfs:subClassOf obo:HP_0033353 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001638 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:MPATH_70 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100027 obo:IAO_0000115 "A recurrent form of pancreatitis." ; dcterms:creator ; oboInOwl:creation_date "2010-06-01T01:45:23Z" ; oboInOwl:hasDbXref "MSH:D050500", "SNOMEDCT_US:233870001", "SNOMEDCT_US:234689009", "SNOMEDCT_US:235494005", "UMLS:C0149521" ; oboInOwl:hasExactSynonym "Recurring pancreas inflammation", "Recurring pancreatitis" ; oboInOwl:id "HP:0100027" ; a owl:Class ; rdfs:label "Recurrent pancreatitis" ; rdfs:subClassOf obo:HP_0001733 . obo:HP_0100028 obo:IAO_0000115 "Mislocalised thyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T10:16:37Z" ; oboInOwl:hasDbXref "MSH:D050033", "SNOMEDCT_US:214660000", "UMLS:C0266283" ; oboInOwl:hasExactSynonym "Aberrant thyroid", "Aberrant thyroid gland", "Abnormal thryoid location", "Ectopic thyroid gland", "Heteropic thyroid gland" ; oboInOwl:id "HP:0100028" ; a owl:Class ; rdfs:comment "An aberrant or ectopic thyroid gland may occur anywhere along the path of initial descent of the thyroid. A total failure to descend contrasts with the incomplete descent of the thyroid, in which case the resulting final resting point of the gland may be high in the neck or just below the hyoid bone. Appart from an abnormal descent, accessory thyroid tissue can also occur, arising from remnants of the thyroglossal duct anywhere along the path of the thyroglossal duct tract." ; rdfs:label "Ectopic thyroid" ; rdfs:subClassOf obo:HP_0008188 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100029 obo:IAO_0000115 "An aberrant thyroid gland or Ectopic thyroid located at the base of the tongue, just posterior to the foramen cecum as a result of a failure of the thyroid to descend." ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T10:20:31Z" ; oboInOwl:hasDbXref "MSH:D046151", "SNOMEDCT_US:129123002", "SNOMEDCT_US:21279007", "UMLS:C0266284" ; oboInOwl:id "HP:0100029" ; a owl:Class ; rdfs:comment "A lingual thyroid is the most common form of an aberrant thyroid gland." ; rdfs:label "Lingual thyroid" ; rdfs:subClassOf obo:HP_0100028 . obo:HP_0100030 obo:IAO_0000115 "Accessory ectopic thyroid tissue arising from remnants of the thyroglossal duct anywhere along the path of the thyroglossal duct tract." ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T10:25:46Z" ; oboInOwl:hasDbXref "UMLS:C4022385" ; oboInOwl:id "HP:0100030" ; a owl:Class ; rdfs:comment "While the accessory thyroid tissue may be functional, it is generally insufficient for normal function if the main thyroid gland is entirely removed." ; rdfs:label "Accessory ectopic thyroid tissue" ; rdfs:subClassOf obo:HP_0100028 . obo:HP_0100031 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the thyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T10:30:24Z" ; oboInOwl:hasDbXref "MSH:D013964", "NCIT:C3262", "SNOMEDCT_US:127018007", "UMLS:C0040136" ; oboInOwl:hasRelatedSynonym "Neoplasia of the thyroid gland" ; oboInOwl:id "HP:0100031" ; a owl:Class ; rdfs:label "Neoplasm of the thyroid gland" ; rdfs:subClassOf obo:HP_0011772, obo:HP_0100568 . obo:HP_0100033 obo:IAO_0000115 "Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppressible and are usually associated with awareness of an urge to perform the movement." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T12:10:29Z" ; oboInOwl:hasDbXref "UMLS:C2169806" ; oboInOwl:hasExactSynonym "Tic disorder" ; oboInOwl:id "HP:0100033" ; a owl:Class ; rdfs:comment "Tics can be invisible to the observer, such as abdominal tensing or toe crunching. Common motor and phonic tics are, respectively, eye blinking and throat clearing. Movements of other movement disorders (for example, chorea, dystonia, myoclonus) must be distinguished from tics. Other conditions, such as autism and stereotypic movement disorder, also include movements which may be confused with tics. Tics must also be distinguished from the compulsions of OCD and from seizure activity. Tics may increase as a result of stress, fatigue, boredom, or high-energy emotions, which can include negative emotions, such as anxiety, but positive emotions as well, such as excitement or anticipation. Relaxation may result in a tic increase (for instance, watching television or using a computer), while concentration on an absorbing activity often leads to a decrease in tics." ; rdfs:label "Tics" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_0100034 obo:IAO_0000115 "Movement-based tics affecting discrete muscle groups." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T12:13:57Z" ; oboInOwl:hasDbXref "MSH:D020323", "UMLS:C0751900" ; oboInOwl:id "HP:0100034" ; a owl:Class ; rdfs:label "Motor tics" ; rdfs:subClassOf obo:HP_0100033 . obo:HP_0100035 obo:IAO_0000115 "Involuntary sounds produced by moving air through the nose, mouth, or throat. The vocal cords are not involved in all tics that produce sound." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T12:13:57Z" ; oboInOwl:hasDbXref "MSH:D020323", "UMLS:C0751901" ; oboInOwl:hasExactSynonym "Verbal tics", "Vocal tics" ; oboInOwl:id "HP:0100035" ; a owl:Class ; rdfs:label "Phonic tics" ; rdfs:subClassOf obo:HP_0100033 . obo:HP_0100036 obo:IAO_0000115 "A band of bone material of decreased density forming alongside the surface of the cortical bone with thickening of the periosteum. Callus formation in the affected area is common and gives the appearance of a false fracture." ; dcterms:creator ; oboInOwl:creation_date "2010-06-14T05:25:53Z" ; oboInOwl:hasDbXref "UMLS:C4021028" ; oboInOwl:hasExactSynonym "Looser zones" ; oboInOwl:id "HP:0100036" ; a owl:Class ; rdfs:comment "Typical sites of involvement are the axillary margins of the scapula, ribs, pubic rami, proximal ends of the femur and ulna. On x-rays pseudo-fractures appear as a lucent line about 1 -2 cm wide, vertical to the cortex and are pathognomonic of osteomalacia, seen on the concave side and are also seen in Paget disease on the convex side of the bone." ; rdfs:label "Pseudo-fractures" ; rdfs:subClassOf obo:HP_0003103 . obo:HP_0100037 obo:IAO_0000115 "An abnormality of the hair of head." ; dcterms:creator ; oboInOwl:creation_date "2010-06-22T05:29:31Z" ; oboInOwl:hasDbXref "UMLS:C4022384" ; oboInOwl:hasExactSynonym "Abnormality of the scalp hair" ; oboInOwl:id "HP:0100037" ; a owl:Class ; rdfs:label "Abnormality of the scalp hair" ; rdfs:subClassOf obo:HP_0001595, obo:HP_0001965 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016446 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100038 obo:IAO_0000115 "Scalp hair whose growth is slower than normal." ; dcterms:creator ; oboInOwl:creation_date "2010-06-22T05:46:59Z" ; oboInOwl:hasAlternativeId "HP:0004553" ; oboInOwl:hasDbXref "UMLS:C4022383" ; oboInOwl:hasExactSynonym "Slow-growing scalp hair" ; oboInOwl:id "HP:0100038" ; a owl:Class ; rdfs:label "Slow-growing scalp hair" ; rdfs:subClassOf obo:HP_0002217, obo:HP_0100037 . obo:HP_0100039 obo:IAO_0000115 "An Abnormality of cortical bone leading to an abnormal thickness of the cortex of affected bones." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:39:01Z" ; oboInOwl:hasDbXref "UMLS:C4022382" ; oboInOwl:id "HP:0100039" ; a owl:Class ; rdfs:label "Thickened cortex of bones" ; rdfs:subClassOf obo:HP_0003103 . obo:HP_0100040 obo:IAO_0000115 "A broad appearance of the second toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:52:57Z" ; oboInOwl:hasDbXref "UMLS:C4022381" ; oboInOwl:hasExactSynonym "Wide 2nd toe" ; oboInOwl:id "HP:0100040" ; a owl:Class ; rdfs:comment "Note that an apparent broad appearance might be due to a hidden duplication." ; rdfs:label "Broad 2nd toe" ; rdfs:subClassOf obo:HP_0001837, obo:HP_0010319 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100041 obo:IAO_0000115 "A broad appearance of the third toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:54:55Z" ; oboInOwl:hasDbXref "UMLS:C4022380" ; oboInOwl:hasExactSynonym "Broad 3rd toe", "Wide 3rd toe" ; oboInOwl:id "HP:0100041" ; a owl:Class ; rdfs:label "Broad 3rd toe" ; rdfs:subClassOf obo:HP_0001837, obo:HP_0010320 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100042 obo:IAO_0000115 "A broad appearance of the fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:55:43Z" ; oboInOwl:hasDbXref "UMLS:C4022379" ; oboInOwl:hasExactSynonym "Broad 4th toe", "Wide 4th toe" ; oboInOwl:id "HP:0100042" ; a owl:Class ; rdfs:label "Broad 4th toe" ; rdfs:subClassOf obo:HP_0001837, obo:HP_0010321 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100043 obo:IAO_0000115 "A broad appearance of the fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:56:25Z" ; oboInOwl:hasDbXref "UMLS:C4022378" ; oboInOwl:hasExactSynonym "Broad 5th toe", "Broad little toe", "Broad pinkie toe", "Broad pinky toe" ; oboInOwl:id "HP:0100043" ; a owl:Class ; rdfs:label "Broad 5th toe" ; rdfs:subClassOf obo:HP_0001837, obo:HP_0010322 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100044 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022377" ; oboInOwl:hasExactSynonym "Absent end part of the 2nd toe bone" ; oboInOwl:id "HP:0100044" ; a owl:Class ; rdfs:label "Absent epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010162, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100045 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022376" ; oboInOwl:hasExactSynonym "Bracket shaped end part of 2nd toe bone" ; oboInOwl:id "HP:0100045" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010163, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100046 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022375" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the 2nd toe bone" ; oboInOwl:id "HP:0100046" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010164, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100047 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022374" ; oboInOwl:hasExactSynonym "Enlarged end part of the 2nd toe bone" ; oboInOwl:id "HP:0100047" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010165, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100048 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022373" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the 2nd toe bone" ; oboInOwl:id "HP:0100048" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010166, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100049 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022372" ; oboInOwl:hasExactSynonym "Irregular end part of the 2nd toe bone" ; oboInOwl:id "HP:0100049" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010167, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100050 obo:IAO_0000115 "Epiphyses of the 2nd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022371" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the 2nd toe" ; oboInOwl:id "HP:0100050" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010168, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100051 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022370" ; oboInOwl:id "HP:0100051" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010169, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100052 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022369" ; oboInOwl:hasExactSynonym "Small end part of the 2nd toe bone" ; oboInOwl:id "HP:0100052" ; a owl:Class ; rdfs:label "Small epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010170, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100053 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022368" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the 2nd toe bone" ; oboInOwl:id "HP:0100053" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010171, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100054 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:18Z" ; oboInOwl:hasDbXref "UMLS:C4022367" ; oboInOwl:hasExactSynonym "Triangular end part of the 2nd toe bone" ; oboInOwl:id "HP:0100054" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 2nd toe" ; rdfs:subClassOf obo:HP_0010172, obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100055 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022366" ; oboInOwl:hasExactSynonym "Absent end part of the 3rd toe" ; oboInOwl:id "HP:0100055" ; a owl:Class ; rdfs:label "Absent epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010162, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100056 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022365" ; oboInOwl:hasExactSynonym "Bracket shaped end part of 3rd toe bone" ; oboInOwl:id "HP:0100056" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010163, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100057 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022364" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the 3rd toe bone" ; oboInOwl:id "HP:0100057" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010164, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100058 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022363" ; oboInOwl:hasExactSynonym "Enlarged end part of the 3rd toe bone" ; oboInOwl:id "HP:0100058" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010165, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100059 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022362" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the 3rd toe bone" ; oboInOwl:id "HP:0100059" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010166, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100060 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022361" ; oboInOwl:hasExactSynonym "Irregular end part of the 3rd toe bone" ; oboInOwl:id "HP:0100060" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010167, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100061 obo:IAO_0000115 "Epiphyses of the 3rd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022360" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the 3rd toe bone" ; oboInOwl:id "HP:0100061" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010168, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100062 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022359" ; oboInOwl:id "HP:0100062" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010169, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100063 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022358" ; oboInOwl:hasExactSynonym "Small end part of the 3rd toe bone" ; oboInOwl:id "HP:0100063" ; a owl:Class ; rdfs:label "Small epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010170, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100064 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022357" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the 3rd toe bone" ; oboInOwl:id "HP:0100064" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010171, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100065 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:58:55Z" ; oboInOwl:hasDbXref "UMLS:C4022356" ; oboInOwl:hasExactSynonym "Triangular end part of the 3rd toe bone" ; oboInOwl:id "HP:0100065" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 3rd toe" ; rdfs:subClassOf obo:HP_0010172, obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100066 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022355" ; oboInOwl:hasExactSynonym "Absent end part of the 4th toe bone" ; oboInOwl:id "HP:0100066" ; a owl:Class ; rdfs:label "Absent epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010162, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100067 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022354" ; oboInOwl:hasExactSynonym "Bracket shaped end part of 4th toe bone" ; oboInOwl:id "HP:0100067" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010163, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100068 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022353" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the 4th toe bone" ; oboInOwl:id "HP:0100068" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010164, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100069 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022352" ; oboInOwl:hasExactSynonym "Enlarged end part of the 4th toe bone" ; oboInOwl:id "HP:0100069" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010165, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100070 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022351" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the 4th toe bone" ; oboInOwl:id "HP:0100070" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010166, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100071 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022350" ; oboInOwl:hasExactSynonym "Irregular end part of the 4th toe bone" ; oboInOwl:id "HP:0100071" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010167, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100072 obo:IAO_0000115 "Epiphyses of the 4th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022349" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the 4th toe bone" ; oboInOwl:id "HP:0100072" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010168, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100073 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022348" ; oboInOwl:id "HP:0100073" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010169, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100074 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022347" ; oboInOwl:hasExactSynonym "Small end part of the 4th toe bone" ; oboInOwl:id "HP:0100074" ; a owl:Class ; rdfs:label "Small epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010170, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100075 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022346" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the 4th toe bone" ; oboInOwl:id "HP:0100075" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010171, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100076 dcterms:creator ; oboInOwl:creation_date "2010-06-24T09:59:30Z" ; oboInOwl:hasDbXref "UMLS:C4022345" ; oboInOwl:hasExactSynonym "Triangular end part of the 4th toe bone" ; oboInOwl:id "HP:0100076" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 4th toe" ; rdfs:subClassOf obo:HP_0010172, obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100077 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022344" ; oboInOwl:hasExactSynonym "Absent end part of the little toe bone", "Absent end part of the pinkie toe bone", "Absent end part of the pinky toe bone" ; oboInOwl:id "HP:0100077" ; a owl:Class ; rdfs:label "Absent epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010162, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100078 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022343" ; oboInOwl:hasExactSynonym "Bracket shaped end part of little toe bone", "Bracket shaped end part of pinkie toe bone", "Bracket shaped end part of pinky toe bone" ; oboInOwl:id "HP:0100078" ; a owl:Class ; rdfs:label "Bracket epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010163, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100079 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022342" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the little toe bone", "Cone-shaped end part of the pinkie toe bone", "Cone-shaped end part of the pinky toe bone" ; oboInOwl:id "HP:0100079" ; a owl:Class ; rdfs:label "Cone-shaped epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010164, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100080 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022341" ; oboInOwl:hasExactSynonym "Enlarged end part of the little toe bone", "Enlarged end part of the pinkie toe bone", "Enlarged end part of the pinky toe bone" ; oboInOwl:id "HP:0100080" ; a owl:Class ; rdfs:label "Enlarged epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010165, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100081 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022340" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the little toe bone", "Fragmentation of the end part of the pinkie toe bone", "Fragmentation of the end part of the pinky toe bone" ; oboInOwl:id "HP:0100081" ; a owl:Class ; rdfs:label "Fragmentation of the epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010166, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100082 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022339" ; oboInOwl:hasExactSynonym "Irregular end part of the little toe bone", "Irregular end part of the pinkie toe bone", "Irregular end part of the pinky toe bone" ; oboInOwl:id "HP:0100082" ; a owl:Class ; rdfs:label "Irregular epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010167, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100083 obo:IAO_0000115 "Epiphyses of the 5th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022338" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the little toe bone", "Increased bone density of end part of the pinkie toe bone", "Increased bone density of end part of the pinky toe bone" ; oboInOwl:id "HP:0100083" ; a owl:Class ; rdfs:label "Ivory epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010168, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100084 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022337" ; oboInOwl:id "HP:0100084" ; a owl:Class ; rdfs:label "Pseudoepiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010169, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100085 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022336" ; oboInOwl:hasExactSynonym "Small end part of the little toe bone", "Small end part of the pinkie toe bone", "Small end part of the pinky toe bone" ; oboInOwl:id "HP:0100085" ; a owl:Class ; rdfs:label "Small epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010170, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100086 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022335" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the little toe bone", "Speckled calcifications in the end part of the pinkie toe bone", "Speckled calcifications in the end part of the pinky toe bone" ; oboInOwl:id "HP:0100086" ; a owl:Class ; rdfs:label "Stippling of the epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010171, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100087 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:00:02Z" ; oboInOwl:hasDbXref "UMLS:C4022334" ; oboInOwl:hasExactSynonym "Triangular end part of the little toe bone", "Triangular end part of the pinkie toe bone", "Triangular end part of the pinky toe bone" ; oboInOwl:id "HP:0100087" ; a owl:Class ; rdfs:label "Triangular epiphyses of the 5th toe" ; rdfs:subClassOf obo:HP_0010172, obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100088 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:01:42Z" ; oboInOwl:hasDbXref "UMLS:C4022333" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100088" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100089 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:01:42Z" ; oboInOwl:hasDbXref "UMLS:C4022332" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100089" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100090 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:01:42Z" ; oboInOwl:hasDbXref "UMLS:C4022331" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100090" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010323 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100091 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:07Z" ; oboInOwl:hasDbXref "UMLS:C4022330" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100091" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100092 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:07Z" ; oboInOwl:hasDbXref "UMLS:C4022329" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100092" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100093 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:07Z" ; oboInOwl:hasDbXref "UMLS:C4022328" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100093" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010329 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100094 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:24Z" ; oboInOwl:hasDbXref "UMLS:C4022327" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100094" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100095 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:24Z" ; oboInOwl:hasDbXref "UMLS:C4022326" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100095" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100096 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:24Z" ; oboInOwl:hasDbXref "UMLS:C4022325" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100096" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100097 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:41Z" ; oboInOwl:hasDbXref "UMLS:C4022324" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the outermost bone of the little toe", "Abnormality of the end part of the outermost bone of the pinkie toe", "Abnormality of the end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100097" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100098 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:41Z" ; oboInOwl:hasDbXref "UMLS:C4022323" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the middle bone of the little toe", "Abnormality of the end part of the middle bone of the pinkie toe", "Abnormality of the end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100098" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100099 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:02:41Z" ; oboInOwl:hasDbXref "UMLS:C4022322" ; oboInOwl:hasExactSynonym "Abnormality of the end part of the innermost bone of the little toe", "Abnormality of the end part of the innermost bone of the pinkie toe", "Abnormality of the end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100099" ; a owl:Class ; rdfs:label "Abnormality of the epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100100 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022321" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100100" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100044, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100101 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022320" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100101" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100045, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100102 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022319" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100102" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100046, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100103 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022318" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100103" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100047, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100104 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022317" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100104" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100048, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100105 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022316" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100105" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100049, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100106 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022315" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100106" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100050, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100107 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022314" ; oboInOwl:id "HP:0100107" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100051, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004316 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100108 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022313" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100108" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100052, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100109 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022312" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100109" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100053, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100110 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:04:20Z" ; oboInOwl:hasDbXref "UMLS:C4022311" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100110" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100054, obo:HP_0100088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100111 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022310" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100111" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100044, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100112 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022309" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100112" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100045, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100113 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022308" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100113" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100046, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100114 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022307" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100114" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100047, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100115 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022306" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100115" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100048, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100116 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022305" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100116" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100049, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100117 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022304" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100117" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100050, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100118 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the second toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022303" ; oboInOwl:id "HP:0100118" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100051, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100119 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022302" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100119" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100052, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100120 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022301" ; oboInOwl:hasExactSynonym "Speckled calcifications in of the end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100120" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100053, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100121 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:05:37Z" ; oboInOwl:hasDbXref "UMLS:C4022300" ; oboInOwl:hasExactSynonym "Triangular end part of the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100121" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100054, obo:HP_0100089 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100122 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022299" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100122" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100044, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100123 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022298" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100123" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100045, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100124 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022297" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100124" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100046, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100125 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022296" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100125" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100047, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100126 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022295" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100126" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100048, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100127 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022294" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100127" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100049, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100128 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022293" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100128" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100050, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100129 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the second toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022292" ; oboInOwl:id "HP:0100129" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100051, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100130 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022291" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100130" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100052, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100131 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022290" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100131" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100053, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100132 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:06:29Z" ; oboInOwl:hasDbXref "UMLS:C4022289" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100132" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100054, obo:HP_0100090 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100133 obo:IAO_0000115 "Abnormality of the growth of the pubic hair. Pubic hair is part of the secondary sexual hair, which normally ensues during puberty." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:15:30Z" ; oboInOwl:hasDbXref "UMLS:C4022288" ; oboInOwl:hasExactSynonym "Abnormality of the pubic hair" ; oboInOwl:id "HP:0100133" ; a owl:Class ; rdfs:label "Abnormality of the pubic hair" ; rdfs:subClassOf obo:HP_0009888 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013698 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100134 obo:IAO_0000115 "Abnormality of the growth of the axillary hair. Axillary hair is part of the secondary sexual hair, which normally ensues during puberty." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:17:00Z" ; oboInOwl:hasDbXref "UMLS:C4022287" ; oboInOwl:id "HP:0100134" ; a owl:Class ; rdfs:label "Abnormality of the axillary hair" ; rdfs:subClassOf obo:HP_0009888 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013699 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100135 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022286" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100135" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100055, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100136 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022285" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100136" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100056, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100137 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022284" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100137" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100057, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100138 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022283" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100138" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100058, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100139 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022282" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100139" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100059, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100140 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022281" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100140" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100060, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100141 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022280" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100141" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100061, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100142 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022279" ; oboInOwl:id "HP:0100142" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100062, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100143 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022278" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100143" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100063, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100144 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 3rd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022277" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100144" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100064, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100145 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:23:44Z" ; oboInOwl:hasDbXref "UMLS:C4022276" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100145" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100065, obo:HP_0100091 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100146 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022275" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100146" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100055, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100147 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022274" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of 3rd toe" ; oboInOwl:id "HP:0100147" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100056, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100148 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022273" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100148" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100057, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100149 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022272" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100149" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100058, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100150 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022271" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100150" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100059, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100151 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022270" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100151" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100060, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100152 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022269" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100152" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100061, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100153 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022268" ; oboInOwl:id "HP:0100153" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100062, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100154 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022267" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100154" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100063, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100155 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 3rd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022266" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100155" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100064, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100156 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:13Z" ; oboInOwl:hasDbXref "UMLS:C4022265" ; oboInOwl:hasExactSynonym "Triangular end part of the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100156" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100065, obo:HP_0100092 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100157 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022264" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100157" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100055, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100158 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022263" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of 3rd toe" ; oboInOwl:id "HP:0100158" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100056, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100159 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022262" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100159" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100057, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100160 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022261" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100160" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100058, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100161 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022260" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100161" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100059, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100162 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022259" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100162" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100060, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100163 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022258" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100163" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100061, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100164 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the third toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022257" ; oboInOwl:id "HP:0100164" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100062, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100165 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022256" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100165" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100063, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100166 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 3rd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022255" ; oboInOwl:hasExactSynonym "Speckled calcifications in of the end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100166" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100064, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100167 dcterms:creator ; oboInOwl:creation_date "2010-06-24T10:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4022254" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100167" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100065, obo:HP_0100093 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100168 obo:IAO_0000115 "Fragmented appearance of the epiphyses." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T11:07:51Z" ; oboInOwl:hasDbXref "UMLS:C4022253" ; oboInOwl:hasExactSynonym "Fragmented end part of bone" ; oboInOwl:id "HP:0100168" ; a owl:Class ; rdfs:label "Fragmented epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040047 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100169 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022252" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100169" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100066, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100170 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022251" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100170" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100067, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100171 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022250" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100171" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100068, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100172 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022249" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100172" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100069, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100173 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022248" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100173" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100070, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100174 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022247" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100174" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100071, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100175 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022246" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100175" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100072, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100176 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022245" ; oboInOwl:id "HP:0100176" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100073, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100177 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022244" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100177" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100074, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100178 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 4th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022243" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100178" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100075, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100179 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:53:36Z" ; oboInOwl:hasDbXref "UMLS:C4022242" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100179" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100076, obo:HP_0100094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100180 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022241" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100180" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100066, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100181 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022240" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100181" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100067, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100182 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022239" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100182" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100068, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100183 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022238" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100183" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100069, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100184 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022237" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100184" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100070, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100185 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022236" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100185" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100071, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100186 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022235" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100186" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100072, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100187 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022234" ; oboInOwl:id "HP:0100187" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100073, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100188 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022233" ; oboInOwl:hasExactSynonym "Small end part of middle long bone of 4th toe" ; oboInOwl:id "HP:0100188" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100074, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100189 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 4th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022232" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100189" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100075, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100190 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:13Z" ; oboInOwl:hasDbXref "UMLS:C4022231" ; oboInOwl:hasExactSynonym "Triangular end part of the middle bone of the 4th toe" ; oboInOwl:id "HP:0100190" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100076, obo:HP_0100095 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100191 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022230" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100191" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100066, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100192 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022229" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of 4th toe" ; oboInOwl:id "HP:0100192" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100067, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100193 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022228" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100193" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100068, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100194 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022227" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100194" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100069, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100195 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022226" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100195" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100070, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100196 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022225" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100196" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100071, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100197 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022224" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100197" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100072, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100198 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fourth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022223" ; oboInOwl:id "HP:0100198" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100073, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100199 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022222" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100199" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100074, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100200 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 4th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022221" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100200" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100075, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100201 dcterms:creator ; oboInOwl:creation_date "2010-06-24T04:54:59Z" ; oboInOwl:hasDbXref "UMLS:C4022220" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100201" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100076, obo:HP_0100096 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100202 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022219" ; oboInOwl:hasExactSynonym "Absent end part of the outermost bone of the little toe", "Absent end part of the outermost bone of the pinkie toe", "Absent end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100202" ; a owl:Class ; rdfs:label "Absent epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100077, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100203 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022218" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the outermost bone of the little toe", "Bracket shaped end part of the outermost bone of the pinkie toe", "Bracket shaped end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100203" ; a owl:Class ; rdfs:label "Bracket epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100078, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100204 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022217" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the outermost bone of the little toe", "Cone-shaped end part of the outermost bone of the pinkie toe", "Cone-shaped end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100204" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100079, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100205 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022216" ; oboInOwl:hasExactSynonym "Enlarged end part of the outermost bone of the little toe", "Enlarged end part of the outermost bone of the pinkie toe", "Enlarged end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100205" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100080, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100206 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022215" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the outermost bone of the little toe", "Fragmentation of the end part of the outermost bone of the pinkie toe", "Fragmentation of the end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100206" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100081, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100207 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022214" ; oboInOwl:hasExactSynonym "Irregular end part of the outermost bone of the little toe", "Irregular end part of the outermost bone of the pinkie toe", "Irregular end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100207" ; a owl:Class ; rdfs:label "Irregular epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100082, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100208 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022213" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the outermost bone of the little toe", "Increased bone density of end part of the outermost bone of the pinkie toe", "Increased bone density of end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100208" ; a owl:Class ; rdfs:label "Ivory epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100083, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100209 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022212" ; oboInOwl:id "HP:0100209" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100084, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100210 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022211" ; oboInOwl:hasExactSynonym "Small end part of the outermost bone of the little toe", "Small end part of the outermost bone of the pinkie toe", "Small end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100210" ; a owl:Class ; rdfs:label "Small epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100085, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100211 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 5th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022210" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the outermost bone of the little toe", "Speckled calcifications in the end part of the outermost bone of the pinkie toe", "Speckled calcifications in the end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100211" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100086, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100212 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:03:31Z" ; oboInOwl:hasDbXref "UMLS:C4022209" ; oboInOwl:hasExactSynonym "Triangular end part of the outermost bone of the little toe", "Triangular end part of the outermost bone of the pinkie toe", "Triangular end part of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100212" ; a owl:Class ; rdfs:label "Triangular epiphysis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100087, obo:HP_0100097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100213 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022208" ; oboInOwl:hasExactSynonym "Absent end part of the middle bone of the little toe", "Absent end part of the middle bone of the pinkie toe", "Absent end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100213" ; a owl:Class ; rdfs:label "Absent epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100077, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100214 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022207" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the middle bone of the little toe", "Bracket shaped end part of the middle bone of the pinkie toe", "Bracket shaped end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100214" ; a owl:Class ; rdfs:label "Bracket epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100078, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100215 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022206" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the middle bone of the little toe", "Cone-shaped end part of the middle bone of the pinkie toe", "Cone-shaped end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100215" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100079, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100216 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022205" ; oboInOwl:hasExactSynonym "Enlarged end part of the middle bone of the little toe", "Enlarged end part of the middle bone of the pinkie toe", "Enlarged end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100216" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100080, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100217 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022204" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the middle bone of the little toe", "Fragmentation of the end part of the middle bone of the pinkie toe", "Fragmentation of the end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100217" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100081, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100218 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022203" ; oboInOwl:hasExactSynonym "Irregular end part of the middle bone of the little toe", "Irregular end part of the middle bone of the pinkie toe", "Irregular end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100218" ; a owl:Class ; rdfs:label "Irregular epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100082, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100219 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022202" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the middle bone of the little toe", "Increased bone density of end part of the middle bone of the pinkie toe", "Increased bone density of end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100219" ; a owl:Class ; rdfs:label "Ivory epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100083, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100220 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022201" ; oboInOwl:id "HP:0100220" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100084, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100221 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022200" ; oboInOwl:hasExactSynonym "Small end part of the middle bone of the little toe", "Small end part of the middle bone of the pinkie toe", "Small end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100221" ; a owl:Class ; rdfs:label "Small epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100085, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100222 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 5th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022199" ; oboInOwl:hasExactSynonym "Speckled calcifications in end part of the innermost bone of the pinkie toe", "Speckled calcifications in middle part of the innermost bone of the little toe", "Speckled calcifications in middle part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100222" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100086, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100223 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:00Z" ; oboInOwl:hasDbXref "UMLS:C4022198" ; oboInOwl:hasExactSynonym "Triangular end part of the middle bone of the little toe", "Triangular end part of the middle bone of the pinkie toe", "Triangular end part of the middle bone of the pinky toe" ; oboInOwl:id "HP:0100223" ; a owl:Class ; rdfs:label "Triangular epiphysis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100087, obo:HP_0100098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100224 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022197" ; oboInOwl:hasExactSynonym "Absent end part of the innermost bone of the little toe", "Absent end part of the innermost bone of the pinkie toe", "Absent end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100224" ; a owl:Class ; rdfs:label "Absent epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100077, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100225 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022196" ; oboInOwl:hasExactSynonym "Bracket shaped end part of the innermost bone of the little toe", "Bracket shaped end part of the innermost bone of the pinkie toe", "Bracket shaped end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100225" ; a owl:Class ; rdfs:label "Bracket epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100078, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002142 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100226 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022195" ; oboInOwl:hasExactSynonym "Cone-shaped end part of the innermost bone of the little toe", "Cone-shaped end part of the innermost bone of the pinkie toe", "Cone-shaped end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100226" ; a owl:Class ; rdfs:label "Cone-shaped epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100079, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002021 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100227 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022194" ; oboInOwl:hasExactSynonym "Enlarged end part of the innermost bone of the little toe", "Enlarged end part of the innermost bone of the pinkie toe", "Enlarged end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100227" ; a owl:Class ; rdfs:label "Enlarged epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100080, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100228 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022193" ; oboInOwl:hasExactSynonym "Fragmentation of the end part of the innermost bone of the little toe", "Fragmentation of the end part of the innermost bone of the pinkie toe", "Fragmentation of the end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100228" ; a owl:Class ; rdfs:label "Fragmentation of the epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100081, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001444 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100229 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022192" ; oboInOwl:hasExactSynonym "Irregular end part of the innermost bone of the little toe", "Irregular end part of the innermost bone of the pinkie toe", "Irregular end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100229" ; a owl:Class ; rdfs:label "Irregular epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100082, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002141 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100230 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022191" ; oboInOwl:hasExactSynonym "Increased bone density of end part of the innermost bone of the little toe", "Increased bone density of end part of the innermost bone of the pinkie toe", "Increased bone density of end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100230" ; a owl:Class ; rdfs:label "Ivory epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100083, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002149 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100231 obo:IAO_0000115 "A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022190" ; oboInOwl:id "HP:0100231" ; a owl:Class ; rdfs:label "Pseudoepiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100084, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0010584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100232 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022189" ; oboInOwl:hasExactSynonym "Small end part of the innermost bone of the little toe", "Small end part of the innermost bone of the pinkie toe", "Small end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100232" ; a owl:Class ; rdfs:label "Small epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100085, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100233 obo:IAO_0000115 "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 5th toe." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022188" ; oboInOwl:hasExactSynonym "Speckled calcifications in the end part of the innermost bone of the little toe", "Speckled calcifications in the end part of the innermost bone of the pinkie toe", "Speckled calcifications in the end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100233" ; a owl:Class ; rdfs:label "Stippling of the epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100086, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001512 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100234 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4022187" ; oboInOwl:hasExactSynonym "Triangular end part of the innermost bone of the little toe", "Triangular end part of the innermost bone of the pinkie toe", "Triangular end part of the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100234" ; a owl:Class ; rdfs:label "Triangular epiphysis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100087, obo:HP_0100099 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001875 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100235 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:26:38Z" ; oboInOwl:hasDbXref "UMLS:C4022186" ; oboInOwl:hasExactSynonym "Fusion involving bones of the toes" ; oboInOwl:id "HP:0100235" ; a owl:Class ; rdfs:label "Synostosis involving bones of the toes" ; rdfs:subClassOf obo:HP_0009140, obo:HP_0100262 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004248 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004248 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100237 dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:37:18Z" ; oboInOwl:hasDbXref "UMLS:C4022185" ; oboInOwl:id "HP:0100237" ; a owl:Class ; rdfs:label "Proximal foot symphalangism" ; rdfs:subClassOf obo:HP_0010179, obo:HP_0100235, obo:HP_0100264 . obo:HP_0100238 obo:IAO_0000115 "An abnormal union between bones or parts of bones of the upper limbs." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T05:49:08Z" ; oboInOwl:hasDbXref "UMLS:C4022184" ; oboInOwl:hasExactSynonym "Fusion involving bones of the upper limbs" ; oboInOwl:id "HP:0100238" ; a owl:Class ; rdfs:label "Synostosis involving bones of the upper limbs" ; rdfs:subClassOf obo:HP_0009810, obo:HP_0100240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0012475 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100240 obo:IAO_0000115 "The abnormal fusion of neighboring bones across a joint." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T06:04:02Z" ; oboInOwl:hasDbXref "UMLS:C4022183" ; oboInOwl:hasExactSynonym "Bony ankylosis", "Fusion of joints" ; oboInOwl:id "HP:0100240" ; a owl:Class ; rdfs:comment "Note that contracture refers to a reduction of joint mobility due to permanent shortening of the soft parts around a joint, muscles, tendons, ligaments, fasciae, or skin. Ankylosis and contracture can occur together or alone. Fibrous ankylosis refers to adhesions between the opposing surface of a joint. Cartilaginous ankylosis implies the fusion of two apposed cartilaginous surfaces. Bony ankylosis or synostosis refers to an osseous union between articulating surfaces." ; rdfs:label "Synostosis of joints" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0011729 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0000982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100241 obo:IAO_0000115 "Ectopic respiratory epithelium presenting as a superficial lesion in the skin usually localised unilateral in the skin of the forearm and associated with ipsilateral hand malformations." ; dcterms:creator ; oboInOwl:creation_date "2010-06-29T11:18:12Z" ; oboInOwl:hasDbXref "UMLS:C4022182" ; oboInOwl:id "HP:0100241" ; a owl:Class ; rdfs:comment "Ectopic respiratory mucosa is a very rare finding and has been associated with unilateral skeletal malformation, most commonly with preaxial polydactyly which may be mirror-image like." ; rdfs:label "Ectopic respiratory mucosa" ; rdfs:subClassOf obo:HP_0002973, obo:HP_0012253 . obo:HP_0100242 obo:IAO_0000115 "A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T10:43:57Z" ; oboInOwl:hasDbXref "MSH:D012509", "NCIT:C9118", "SNOMEDCT_US:2424003", "SNOMEDCT_US:269469005", "SNOMEDCT_US:424413001", "SNOMEDCT_US:424952003", "UMLS:C1261473" ; oboInOwl:hasExactSynonym "Cancer of connective tissue", "Malignant connective tissue tumor", "Malignant connective tissue tumour" ; oboInOwl:id "HP:0100242" ; a owl:Class ; rdfs:comment "A sarcoma (from the Greek sarx meaning flesh) is a general term describing a malignant neoplasm, or cancer, that arises from transformed connective tissue cells such as bone, cartilage and fat cells, which originate from embryonic mesoderm. This is in contrast to carcinomas, which are of epithelial origin (breast, colon, pancreas, and others). However, due to an evolving understanding of tissue origin, the term sarcoma is sometimes applied to tumors now known to arise from epithelial tissue. The term soft tissue sarcoma is used to describe tumors of soft tissue, which includes elements that are in connective tissue, but not derived from it (such as muscles and blood vessels)." ; rdfs:label "Sarcoma" ; rdfs:subClassOf obo:HP_0011792 . obo:HP_0100243 obo:IAO_0000115 "A smooth muscle connective tissue tumor, which is rare type of cancer that is a malignant neoplasm of smooth muscle. When such a neoplasm is benign, it is called a leiomyoma." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T10:49:35Z" ; oboInOwl:hasDbXref "MSH:D007890", "NCIT:C3158", "SNOMEDCT_US:443719001", "SNOMEDCT_US:51549004", "UMLS:C0023269" ; oboInOwl:id "HP:0100243" ; a owl:Class ; rdfs:label "Leiomyosarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0100244 obo:IAO_0000115 "A fibroblastic sarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T10:55:40Z" ; oboInOwl:hasDbXref "MSH:D005354", "NCIT:C6605", "SNOMEDCT_US:443250000", "SNOMEDCT_US:53654007", "UMLS:C0016057" ; oboInOwl:id "HP:0100244" ; a owl:Class ; rdfs:label "Fibrosarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0100245 obo:IAO_0000115 "Benign, slow-growing tumors without any metastatic potential. Despite their benign nature, they can damage nearby structures causing organ dysfunction. Histologically they resemble low-grade fibrosarcomas, but they are very locally aggressive and tend to recur even after complete resection. There is a tendency for recurrence in the setting of prior surgery and the most common localisation of these tumors is intraabdominal from smooth muscle cells of the instestine." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T10:57:06Z" ; oboInOwl:hasDbXref "MSH:D018222", "NCIT:C3042", "SNOMEDCT_US:399994005", "SNOMEDCT_US:400055004", "SNOMEDCT_US:47284001", "UMLS:C0079218" ; oboInOwl:hasExactSynonym "Desmoid tumours" ; oboInOwl:id "HP:0100245" ; a owl:Class ; rdfs:comment """Most cases are sporadic, but some are associated with familial adenomatous polyposis (FAP). Approximately 10% of individuals with Gardner's syndrome, a type of FAP with extracolonic features, have desmoid tumors. Risk factors for desmoid disease amongst FAP patients include female gender, a 3' APC mutation, a positive family history and a history of previous abdominal surgery.""" ; rdfs:label "Desmoid tumors" ; rdfs:subClassOf obo:HP_0007378, obo:HP_0010614, obo:HP_0100244 . obo:HP_0100246 obo:IAO_0000115 "Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T11:38:30Z" ; oboInOwl:hasDbXref "MSH:D010016", "NCIT:C3296", "SNOMEDCT_US:302858007", "SNOMEDCT_US:83612000", "UMLS:C0029440" ; oboInOwl:id "HP:0100246" ; a owl:Class ; rdfs:label "Osteoma" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0100247 obo:IAO_0000115 "A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc." ; dcterms:creator ; oboInOwl:creation_date "2010-07-08T05:28:00Z" ; oboInOwl:hasDbXref "MSH:D006606", "SNOMEDCT_US:65958008", "UMLS:C0019521", "UMLS:C0744897" ; oboInOwl:hasExactSynonym "Recurrent hiccough", "Recurrent hiccup", "Recurrent synchronous diaphragmatic flutter" ; oboInOwl:hasRelatedSynonym "Hiccup", "Hiccups" ; oboInOwl:id "HP:0100247" ; a owl:Class ; rdfs:comment "A bout of hiccups, in general, resolves itself without intervention, although many home remedies claim to shorten the duration, and medical treatment is occasionally necessary in cases of chronic hiccups. Hiccups are caused by many central and peripheral nervous system disorders, all from injury or irritation to the phrenic and vagus nerves, as well as toxic or metabolic disorders affecting the aforementioned systems. Hiccups often occur after consuming carbonated beverages, alcohol, dry breads, or spicy foods. Prolonged laughter or eating too fast are also known to cause hiccups. Persistent or intractable hiccups may be caused by any condition which irritates or damages the relevant nerves." ; rdfs:label "Recurrent singultus" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0100248 obo:IAO_0000115 "Hemiballismus is a rare movement disorder that is caused primarily by damage to various areas in the basal ganglia. Hemiballismus is usually characterized by involuntary flinging motions of the extremities. The movements are often violent and have wide amplitudes of motion. They are continuous and random and can involve proximal and/or distal muscles on one side of the body, while some cases even include the facial muscles. The more a patient is active, the more the movements increase. With relaxation comes a decrease in movements." ; dcterms:creator ; oboInOwl:creation_date "2010-07-09T12:21:41Z" ; oboInOwl:hasDbXref "MSH:D020820", "SNOMEDCT_US:66637005", "UMLS:C0221169" ; oboInOwl:hasRelatedSynonym "Ballismus" ; oboInOwl:id "HP:0100248" ; a owl:Class ; rdfs:comment "Hemiballismus is a very rare movement disorder. It is five hundred times rarer than Parkinson disease. Its effects can sometimes be severe enough to prevent patients from being able to perform daily functions. It is usually associated with structural brain lesions but can occur with metabolic abnormalities. The symptoms can also decrease while the patient is asleep, unlike some movement disorders. Ballism refers to very large-amplitude choreic movements of the proximal parts of the limbs, causing flinging and flailing limb movements. Ballism is most frequently unilateral, in which case it is referred to as hemiballism" ; rdfs:label "Hemiballismus" ; rdfs:subClassOf obo:HP_0002134, obo:HP_0004305, obo:HP_0011442 . obo:HP_0100249 obo:IAO_0000115 "Deposition of calcium salts in muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2010-07-09T12:32:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:446993003", "UMLS:C2960760" ; oboInOwl:hasExactSynonym "Skeletal muscle calcinosis" ; oboInOwl:id "HP:0100249" ; a owl:Class ; rdfs:label "Calcification of muscles" ; rdfs:subClassOf obo:HP_0010766, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001015 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100250 obo:IAO_0000115 "Calcium deposition affecting the Meninges." ; dcterms:creator ; oboInOwl:creation_date "2010-07-14T03:41:34Z" ; oboInOwl:hasDbXref "UMLS:C4022181" ; oboInOwl:id "HP:0100250" ; a owl:Class ; rdfs:comment "In general, meningeal calcifications are plaque-like and bilateral as seen on CT-scans." ; rdfs:label "Meningeal calcification" ; rdfs:subClassOf obo:HP_0002514, obo:HP_0010651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010743 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100251 obo:IAO_0000115 "The presence of multiple lipomas located in the central nervous system." ; dcterms:creator ; oboInOwl:creation_date "2010-07-14T03:55:50Z" ; oboInOwl:hasDbXref "NCIT:C3192", "UMLS:C4022180" ; oboInOwl:hasExactSynonym "Lipomas of the central nervous system" ; oboInOwl:id "HP:0100251" ; a owl:Class ; rdfs:label "Multiple central nervous system lipomas" ; rdfs:subClassOf obo:HP_0001012, obo:HP_0100835 . obo:HP_0100252 dcterms:creator ; oboInOwl:creation_date "2010-07-14T05:01:38Z" ; oboInOwl:hasDbXref "MSH:D003966", "SNOMEDCT_US:318761000119105", "SNOMEDCT_US:34643004", "UMLS:C0011989" ; oboInOwl:id "HP:0100252" ; a owl:Class ; rdfs:label "Diaphyseal dysplasia" ; rdfs:subClassOf obo:HP_0000940, obo:HP_0002652 . obo:HP_0100253 obo:IAO_0000115 "An abnormality of the medullary cavity (medulla, innermost part), which is the central cavity of bone shafts where red bone marrow and/or yellow bone marrow (adipose tissue) is stored." ; dcterms:creator ; oboInOwl:creation_date "2010-07-14T05:09:21Z" ; oboInOwl:hasDbXref "UMLS:C4021027" ; oboInOwl:hasExactSynonym "Abnormality of the marrow cavity of the long bones" ; oboInOwl:id "HP:0100253" ; a owl:Class ; rdfs:label "Abnormality of the medullary cavity of the long bones" ; rdfs:subClassOf obo:HP_0000940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0016413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100254 dcterms:creator ; oboInOwl:creation_date "2010-07-14T05:13:39Z" ; oboInOwl:hasDbXref "UMLS:C4022179" ; oboInOwl:id "HP:0100254" ; a owl:Class ; rdfs:label "Stenosis of the medullary cavity of the long bones" ; rdfs:subClassOf obo:HP_0100253 . obo:HP_0100255 obo:IAO_0000115 "The presence of dysplastic regions in metaphyseal regions." ; dcterms:creator ; oboInOwl:creation_date "2010-07-14T05:15:56Z" ; oboInOwl:hasAlternativeId "HP:0000948", "HP:0005002", "HP:0005636", "HP:0005704", "HP:0005899", "HP:0006427" ; oboInOwl:hasDbXref "MSH:C536252", "SNOMEDCT_US:27837003", "UMLS:C0265294" ; oboInOwl:id "HP:0100255" ; a owl:Class ; rdfs:label "Metaphyseal dysplasia" ; rdfs:subClassOf obo:HP_0000944, obo:HP_0002652 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001438 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100256 obo:IAO_0000115 "Senile plaques are extracellular deposits of amyloid in the gray matter of the brain." ; dcterms:creator ; oboInOwl:creation_date "2010-07-15T02:43:44Z" ; oboInOwl:hasDbXref "MSH:D058225", "SNOMEDCT_US:38551001", "UMLS:C0333463" ; oboInOwl:hasExactSynonym "Braindruse", "Neuritic plaques", "Senile druse" ; oboInOwl:id "HP:0100256" ; a owl:Class ; rdfs:comment "Senile plaques can be found in human and animal brains. From an age of 60 years (10%) to an age of 80 years (60%) the proportion of people with plaques increases approximately linearly. A small number of plaques can be due to the physiological process of aging. Women are slightly more likely to have plaques than males. The plaques occur commonly in the amygdoid nucleus and the sulci of the cortex of brain. The deposits are associated with degenerative neural structures and an abundance of microglia and astrocytes. Large numbers of senile plaques and neurofibrillary tangles are characteristic features of Alzheimers disease, and some of the abnormal neurites in senile plaques are composed primarily of paired helical filaments, a component of neurofibrillary tangles. In Alzheimer's disease they are primarily composed of amyloid beta peptides. These polypeptides tend to aggregate and are believed to be neurotoxic." ; rdfs:label "Senile plaques" ; rdfs:subClassOf obo:HP_0007367 . obo:HP_0100257 obo:IAO_0000115 "A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet." ; dcterms:creator ; oboInOwl:creation_date "2010-07-15T03:56:58Z" ; oboInOwl:hasDbXref "MSH:C574275", "SNOMEDCT_US:13624003", "SNOMEDCT_US:81208006", "UMLS:C0265554" ; oboInOwl:hasExactSynonym "Cleft hand", "Lobster claw hand" ; oboInOwl:id "HP:0100257" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Hands and feet in one individual might be similarly affected or very diverse and the phenotype is very variable even within families. Penetrance is reduced and some idnividuals have been observed presenting only with unilateral smaller 2nd toe which may be overlooked till a much more severly affected family member is seen." ; rdfs:label "Ectrodactyly" ; rdfs:subClassOf obo:HP_0002813 . obo:HP_0100258 obo:IAO_0000115 "A form of polydactyly in which the extra digit or digits are localized on the side of the thumb or great toe." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T11:00:32Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:205135003", "UMLS:C0345354" ; oboInOwl:hasExactSynonym "Polydactyly, preaxial" ; oboInOwl:id "HP:0100258" ; a owl:Class ; rdfs:label "Preaxial polydactyly" ; rdfs:subClassOf obo:HP_0010442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0001177 obo:HP_0001841 ) ] ] . obo:HP_0100259 obo:IAO_0000115 "A form of polydactyly in which the extra digit or digits are localized on the side of the fifth finger or fifth toe." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T11:00:32Z" ; oboInOwl:hasAlternativeId "HP:0005808" ; oboInOwl:hasDbXref "MSH:C562429", "UMLS:C0220697" ; oboInOwl:hasExactSynonym "Polydactyly, postaxial", "Postaxial hexadactyly" ; oboInOwl:id "HP:0100259" ; a owl:Class ; rdfs:label "Postaxial polydactyly" ; rdfs:subClassOf obo:HP_0010442 . obo:HP_0100260 obo:IAO_0000115 "The presence of a supernumerary finger or toe (not a thumb or hallux) involving the third or fourth metacarpal/tarsal with associated osseous syndactyly." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T11:00:32Z" ; oboInOwl:hasDbXref "UMLS:C1848595", "UMLS:C4020689" ; oboInOwl:hasExactSynonym "Central polydactyly", "Intercalary polydactyly" ; oboInOwl:hasRelatedSynonym "Insertional polydactyly" ; oboInOwl:id "HP:0100260" ; a owl:Class ; rdfs:label "Mesoaxial polydactyly" ; rdfs:subClassOf obo:HP_0010442 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0019222 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100261 obo:IAO_0000115 "An abnormality of the structure or form of the tendons, also often called sinews." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T01:20:19Z" ; oboInOwl:hasDbXref "UMLS:C4021026" ; oboInOwl:hasExactSynonym "Abnormal shape of tendon", "Abnormality of the sinew" ; oboInOwl:id "HP:0100261" ; a owl:Class ; rdfs:comment "A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. Tendons are similar to ligaments and fascia as they are all made of collagen except that ligaments join one bone to another bone, and fascia connect muscles to other muscles. Tendons and muscles work together and can only exert a pulling force." ; rdfs:label "Abnormal tendon morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100262 dcterms:creator ; oboInOwl:creation_date "2010-07-20T02:58:46Z" ; oboInOwl:hasDbXref "UMLS:C4022178" ; oboInOwl:hasExactSynonym "Fusion involving digits" ; oboInOwl:id "HP:0100262" ; a owl:Class ; rdfs:label "Synostosis involving digits" ; rdfs:subClassOf obo:HP_0100240 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100263 dcterms:creator ; oboInOwl:creation_date "2010-07-20T03:00:19Z" ; oboInOwl:hasDbXref "MSH:C566099", "UMLS:C1861401" ; oboInOwl:hasExactSynonym "Symphalangism, distal" ; oboInOwl:id "HP:0100263" ; a owl:Class ; rdfs:label "Distal symphalangism" ; rdfs:subClassOf obo:HP_0100262 . obo:HP_0100264 dcterms:creator ; oboInOwl:creation_date "2010-07-20T03:00:19Z" ; oboInOwl:hasDbXref "MSH:C536223", "UMLS:C1861385" ; oboInOwl:hasExactSynonym "Cushing's symphalangism" ; oboInOwl:id "HP:0100264" ; a owl:Class ; rdfs:label "Proximal symphalangism" ; rdfs:subClassOf obo:HP_0100262 . obo:HP_0100265 dcterms:creator ; oboInOwl:creation_date "2010-07-20T03:02:10Z" ; oboInOwl:hasDbXref "UMLS:C4022177" ; oboInOwl:hasExactSynonym "Fusion of long bones of hand/long bones of foot" ; oboInOwl:id "HP:0100265" ; a owl:Class ; rdfs:label "Synostosis of metacarpals/metatarsals" ; rdfs:subClassOf obo:HP_0100240 . obo:HP_0100266 obo:IAO_0000115 "The carpus consists of the scaphoid, lunate, triquetal, pisiform, captitate, hamate, trapezoid, and trapezium bones. The tarsus consists of the talus, calcaneus, cuboid, cuneiform, and navicular bones. This term applies if there is any fusion among the bones of the carpus or tarsus." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T03:02:14Z" ; oboInOwl:hasAlternativeId "HP:0005666", "HP:0005675", "HP:0005823" ; oboInOwl:hasDbXref "UMLS:C4021025" ; oboInOwl:hasExactSynonym "Carpal and tarsal fusions", "Coalescence of carpal and tarsal bones", "Fusion of carpal and tarsal bones", "Wrist bone/ankle bone fusions" ; oboInOwl:id "HP:0100266" ; a owl:Class ; rdfs:label "Synostosis of carpals/tarsals" ; rdfs:subClassOf obo:HP_0100240 . obo:HP_0100267 obo:IAO_0000115 "A depression located on a lip." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T04:06:32Z" ; oboInOwl:hasDbXref "UMLS:C0341059" ; oboInOwl:id "HP:0100267" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lip pit" ; rdfs:subClassOf obo:HP_0000159, obo:HP_0100276 . obo:HP_0100268 obo:IAO_0000115 "Depression located on the vermilion of the upper lip, usually paramedian." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T04:06:52Z" ; oboInOwl:hasDbXref "UMLS:C4022176" ; oboInOwl:id "HP:0100268" ; a owl:Class ; rdfs:comment "A lip pit may be connected by a fistula to mucous minor salivary glands in the upper lip. In addition, a lip pit may on occasion be seen with a surrounding tissue elevation (mound). Pits located at the labial commisure (cheilon) are distinct from lip pits (see Commissural pit)." ; rdfs:label "Upper lip pit" ; rdfs:subClassOf obo:HP_0000177, obo:HP_0100269 . obo:HP_0100269 obo:IAO_0000115 "Depression located paramedially on the vermilion of a lip." ; dcterms:creator ; oboInOwl:creation_date "2010-07-20T04:13:41Z" ; oboInOwl:hasDbXref "UMLS:C4022175" ; oboInOwl:hasExactSynonym "Paramedian labial pits" ; oboInOwl:id "HP:0100269" ; a owl:Class ; rdfs:comment "A lip pit may be connected by a fistula to mucous minor salivary glands in the upper or lower lip. In addition, a lip pit may on occasion be seen with a surrounding tissue elevation (mound). Pits located at the labial commisure (cheilon) are distinct from lip pits (see Commissural pit)." ; rdfs:label "Paramedian lip pit" ; rdfs:subClassOf obo:HP_0100267 . obo:HP_0100270 obo:IAO_0000115 "An abnormality resulting from a defect or disruption of dorsoventral patterning that normally happens during early development of the limbs. A disruption of the normal development of the dorsoventral axis may lead to a variable spectrum of different phenotypic abnormalities that may affect the nails and or palmar and dorsal side of the hands and/or feet, ultimately changing the normal dorsoventral appearance of the affected limbs." ; dcterms:creator ; oboInOwl:creation_date "2010-07-22T05:02:27Z" ; oboInOwl:hasDbXref "UMLS:C4022174" ; oboInOwl:id "HP:0100270" ; a owl:Class ; rdfs:label "Abnormality of dorsoventral patterning of the limbs" ; rdfs:subClassOf obo:HP_0001155, obo:HP_0001760 . obo:HP_0100271 obo:IAO_0000115 "Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion." ; dcterms:creator ; oboInOwl:creation_date "2010-07-27T09:57:48Z" ; oboInOwl:hasDbXref "UMLS:C4022173" ; oboInOwl:id "HP:0100271" ; a owl:Class ; rdfs:label "Hyponasal speech" ; rdfs:subClassOf obo:HP_0001608 . obo:HP_0100272 obo:IAO_0000115 "A congenital branchial sinus is a remnant of the embryonic branchial arches and their intervening clefts and pouches that has failed to regress completely. Sinuses typically have their external orifice inferior to the ramus of the mandible. They may traverse the parotid gland, and run in close vicinity to the facial nerve in the external auditory canal." ; dcterms:creator ; oboInOwl:creation_date "2010-07-27T10:10:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253259008", "UMLS:C0266624" ; oboInOwl:hasExactSynonym "Branchial cleft sinus" ; oboInOwl:id "HP:0100272" ; a owl:Class ; rdfs:comment "Branchial sinuses have to be distinguished from the preauricular cysts and sinuses, which are ectodermal remnants from an aberrant development of the auditory tubercles, tend to be bilateral, and are localized anterior to the tragus of the ear." ; rdfs:label "Branchial sinus" ; rdfs:subClassOf obo:HP_0009794 . obo:HP_0100273 dcterms:creator ; oboInOwl:creation_date "2010-07-28T05:37:31Z" ; oboInOwl:hasDbXref "MSH:D003110", "NCIT:C3262", "SNOMEDCT_US:126838000", "UMLS:C0009375" ; oboInOwl:hasExactSynonym "Colon tumor", "Colon tumour" ; oboInOwl:id "HP:0100273" ; a owl:Class ; rdfs:label "Neoplasm of the colon" ; rdfs:subClassOf obo:HP_0100834 . obo:HP_0100274 obo:IAO_0000115 "Gustatory lacrimation results from an aberrant innervation of fibres from the seventh cranial nerve to the pterygopalatine ganglion which are destined originally for the submandibular ganglion. This aberrant innervation leads to uncontrollable tearing while eating or in anticipation of a meal." ; dcterms:creator ; oboInOwl:creation_date "2010-07-29T11:59:06Z" ; oboInOwl:hasDbXref "UMLS:C1862052" ; oboInOwl:id "HP:0100274" ; a owl:Class ; rdfs:comment "The aberrant innervation leading to this phenomenon may be seen for example as a hereditary trait in some patients with Branchio-oto-renal (BOR) syndrome in which case it may occur unilateral or bilateral, but it may also result from a secondary aberrant reinnervation following a peripheral facial palsy, in which case it is associated with uncontrollable ipsilateral tearing. In the past gustatory lacrimation was considered to be a very rare non-hereditary type of anomalous, cranial nerve-end organ innervation but rare occurences in patients with Branchio-oto-renal (BOR) syndrome have shown, that this feature may also appear as a hereditary condition." ; rdfs:label "Gustatory lacrimation" ; rdfs:subClassOf obo:HP_0000632, obo:HP_0031910 . obo:HP_0100275 obo:IAO_0000115 "Diffuse unlocalised atrophy affecting the cerebellum." ; dcterms:creator ; oboInOwl:creation_date "2010-08-02T01:22:19Z" ; oboInOwl:hasAlternativeId "HP:0006928" ; oboInOwl:hasDbXref "UMLS:C1854699" ; oboInOwl:id "HP:0100275" ; a owl:Class ; rdfs:label "Diffuse cerebellar atrophy" ; rdfs:subClassOf obo:HP_0001272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001272 [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000635 ] ) ] ] . obo:HP_0100276 obo:IAO_0000115 "A small, skin-lined tract that leads from the surface to deep within the tissues." ; dcterms:creator ; oboInOwl:creation_date "2010-08-05T10:51:32Z" ; oboInOwl:hasDbXref "UMLS:C4020712", "UMLS:C4022172" ; oboInOwl:hasExactSynonym "Skin pit" ; oboInOwl:hasRelatedSynonym "Skin pits" ; oboInOwl:id "HP:0100276" ; a owl:Class ; rdfs:label "Skin pit" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0100277 obo:IAO_0000115 "Benign congenital lesions of the periauricular soft tissue consisting of a blind-ending narrow tube or pit." ; dcterms:creator ; oboInOwl:creation_date "2010-08-05T10:54:32Z" ; oboInOwl:hasDbXref "UMLS:C4022171" ; oboInOwl:hasExactSynonym "Periauricular earpits", "Periauricular fistulas", "Periauricular pits", "Periauricular sinus", "Pits around the ear" ; oboInOwl:id "HP:0100277" ; a owl:Class ; rdfs:label "Periauricular skin pits" ; rdfs:subClassOf obo:HP_0000383, obo:HP_0100276 . obo:HP_0100279 obo:IAO_0000115 "A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T09:25:44Z" ; oboInOwl:hasDbXref "MSH:D003093", "SNOMEDCT_US:64766004", "UMLS:C0009324" ; oboInOwl:hasExactSynonym "Colitis ulcerosa" ; oboInOwl:id "HP:0100279" ; a owl:Class ; rdfs:label "Ulcerative colitis" ; rdfs:subClassOf obo:HP_0100281 . obo:HP_0100280 obo:IAO_0000115 "A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T09:26:05Z" ; oboInOwl:hasDbXref "MSH:D003424", "SNOMEDCT_US:34000006", "UMLS:C0010346" ; oboInOwl:hasExactSynonym "Granulomatous enteritis and colitis", "Morbus Crohn" ; oboInOwl:id "HP:0100280" ; a owl:Class ; rdfs:label "Crohn's disease" ; rdfs:subClassOf obo:HP_0004386 . obo:HP_0100281 obo:IAO_0000115 "A chronic inflammatory disease of the large intestine (colon, cecum and rectum)." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T09:26:33Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:54597004", "UMLS:C0267375" ; oboInOwl:id "HP:0100281" ; a owl:Class ; rdfs:label "Chronic colitis" ; rdfs:subClassOf obo:HP_0002583 . obo:HP_0100282 obo:IAO_0000115 "An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum)." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T09:26:33Z" ; oboInOwl:hasDbXref "UMLS:C2118460" ; oboInOwl:id "HP:0100282" ; a owl:Class ; rdfs:label "Acute colitis" ; rdfs:subClassOf obo:HP_0002583 . obo:HP_0100283 obo:IAO_0000115 "Continuous electromyographic activity of motor units at rest, i.e., without voluntary movement of the muscles." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T12:59:19Z" ; oboInOwl:hasDbXref "UMLS:C4022170" ; oboInOwl:id "HP:0100283" ; a owl:Class ; rdfs:comment "The motor unit contains an anterior horn cell, its axon, and all of the muscle fibers that it innervates via the neuromuscular junction. Note that a healthy relaxed muscle does not show significant EMG activity at rest." ; rdfs:label "EMG: continuous motor unit activity at rest" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0100284 obo:IAO_0000115 "High frequency discharges in electromyography (EMG) that vary in amplitude and frequency, waxing and waning continuously with firing frequencies ranging from 150/second down to 20/second and producing a sound that has been referred to as a dive bomber sound." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:02:13Z" ; oboInOwl:hasDbXref "UMLS:C4022169" ; oboInOwl:id "HP:0100284" ; a owl:Class ; rdfs:label "EMG: myotonic discharges" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0100285 obo:IAO_0000115 "An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP)." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:02:59Z" ; oboInOwl:hasDbXref "UMLS:C4022168" ; oboInOwl:id "HP:0100285" ; a owl:Class ; rdfs:label "EMG: impaired neuromuscular transmission" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0100287 obo:IAO_0000115 "The presence of reduced conduction velocity of motor nerves on electromyography." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:11:48Z" ; oboInOwl:hasDbXref "UMLS:C4022167" ; oboInOwl:id "HP:0100287" ; a owl:Class ; rdfs:label "EMG: slow motor conduction" ; rdfs:subClassOf obo:HP_0003457 . obo:HP_0100288 obo:IAO_0000115 "The presence of spontaneous bursts of rapidly firing potentials that recur at regular intervals of 2-10 per second and are unaffected by voluntary effort. This is an electromyographic (EMG) finding." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:12:27Z" ; oboInOwl:hasDbXref "UMLS:C4022166" ; oboInOwl:id "HP:0100288" ; a owl:Class ; rdfs:label "EMG: myokymic discharges" ; rdfs:subClassOf obo:HP_0002411, obo:HP_0003457 . obo:HP_0100289 dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:20:56Z" ; oboInOwl:hasDbXref "UMLS:C4022165" ; oboInOwl:hasExactSynonym "Abnormality of pattern reversal VEP" ; oboInOwl:id "HP:0100289" ; a owl:Class ; rdfs:label "Abnormality of pattern reversal visual evoked potentials" ; rdfs:subClassOf obo:HP_0030455 . obo:HP_0100290 dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:31:37Z" ; oboInOwl:hasDbXref "UMLS:C4022164" ; oboInOwl:id "HP:0100290" ; a owl:Class ; rdfs:label "Abnormality of peripheral somatosensory evoked potentials" ; rdfs:subClassOf obo:HP_0007377 . obo:HP_0100291 dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:31:37Z" ; oboInOwl:hasDbXref "UMLS:C4022163" ; oboInOwl:id "HP:0100291" ; a owl:Class ; rdfs:label "Abnormality of central somatosensory evoked potentials" ; rdfs:subClassOf obo:HP_0007377 . obo:HP_0100292 obo:IAO_0000115 "The presence of amyloid deposition in the nerves of the peripheral nervous system." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:46:51Z" ; oboInOwl:hasDbXref "UMLS:C4022162" ; oboInOwl:id "HP:0100292" ; a owl:Class ; rdfs:label "Amyloidosis of peripheral nerves" ; rdfs:subClassOf obo:HP_0000759, obo:HP_0011034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_34 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001021 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100293 obo:IAO_0000115 "The presence of an increased amount of muscle fibers with an increased diameter. This feature can be ascertained by microscopic examination of a muscle biopsy sample. Together with fiber size variation and atrophied muscle fibers, and hypertrophied muscle fibers are commonly found in myopathies." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:57:00Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:42091004", "UMLS:C0333759" ; oboInOwl:hasExactSynonym "Muscle fiber hypertrophy", "Muscle fibre hypertrophy" ; oboInOwl:id "HP:0100293" ; a owl:Class ; rdfs:comment "Muscle hypertrophy can be assessed at the whole-muscle level (macroscopic methods) or the muscle fiber level (microscopic methods). This term refers to hypertrophy assessed at the microscopic level." ; rdfs:label "Hypertrophied muscle fibers" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000188 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100295 dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:58:24Z" ; oboInOwl:hasAlternativeId "HP:0100294" ; oboInOwl:hasDbXref "SNOMEDCT_US:67867005", "UMLS:C0333751" ; oboInOwl:hasExactSynonym "Muscle fiber degeneration", "Muscle fibre atrophy", "Muscle fibre degeneration" ; oboInOwl:id "HP:0100295" ; a owl:Class ; rdfs:label "Muscle fiber atrophy" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000188 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100296 dcterms:creator ; oboInOwl:creation_date "2010-08-10T01:59:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:87196003", "UMLS:C0333757" ; oboInOwl:hasExactSynonym "Perifascicular muscle fibre atrophy" ; oboInOwl:id "HP:0100296" ; a owl:Class ; rdfs:label "Perifascicular muscle fiber atrophy" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0100297 obo:IAO_0000115 "An increased volume of the endomysium, which is a connective tissue sheath that surrounds each muscule fiber. Together, bundles of muscle fibers form a fasciculus, surrounded by another layer of connective tissue called the perimysium." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:06:32Z" ; oboInOwl:hasDbXref "UMLS:C4022161" ; oboInOwl:hasExactSynonym "Endomysial fibrosis" ; oboInOwl:id "HP:0100297" ; a owl:Class ; rdfs:label "Increased endomysial connective tissue" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0100298 dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:19:26Z" ; oboInOwl:hasDbXref "UMLS:C4022160" ; oboInOwl:hasExactSynonym "Motheaten muscle fibres" ; oboInOwl:id "HP:0100298" ; a owl:Class ; rdfs:label "Motheaten muscle fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0100299 dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:21:34Z" ; oboInOwl:hasDbXref "UMLS:C4022159" ; oboInOwl:hasExactSynonym "Muscle fibre inclusion bodies" ; oboInOwl:id "HP:0100299" ; a owl:Class ; rdfs:comment "This should have logical def changed to reference a generic muscle fiber but this is not yet in CL." ; rdfs:label "Muscle fiber inclusion bodies" ; rdfs:subClassOf obo:HP_0004303 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002002 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0016234 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000187 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100300 dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:28:49Z" ; oboInOwl:hasDbXref "UMLS:C4022158" ; oboInOwl:id "HP:0100300" ; a owl:Class ; rdfs:label "Desmin bodies" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0100301 obo:IAO_0000115 "Unusual regions of densely packed membranous tubules known as tubular aggregates which present as membranous inclusions, derived from membranes of sarcoplasmic reticulum and mitochondria, containing miscellaneous proteins with a variety of enzymatic activities." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:31:27Z" ; oboInOwl:hasDbXref "UMLS:C4021024" ; oboInOwl:hasExactSynonym "Muscle fiber tubular aggregates", "Muscle fibre tubular aggregates", "Muscle fibre tubular inclusions" ; oboInOwl:id "HP:0100301" ; a owl:Class ; rdfs:label "Muscle fiber tubular inclusions" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0100302 dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:36:48Z" ; oboInOwl:hasDbXref "UMLS:C4021023" ; oboInOwl:hasExactSynonym "Muscle fiber tubuloreticular aggregates", "Muscle fibre tubuloreticular aggregates", "Muscle fibre tubuloreticular inclusions" ; oboInOwl:id "HP:0100302" ; a owl:Class ; rdfs:label "Muscle fiber tubuloreticular inclusions" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0100303 obo:IAO_0000115 "The presence of inclusion bodies within the cytoplasm of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:39:22Z" ; oboInOwl:hasAlternativeId "HP:0003790" ; oboInOwl:hasDbXref "UMLS:C4022157" ; oboInOwl:hasExactSynonym "Muscle fiber cytoplasmic bodies", "Muscle fibre cytoplasmatic inclusion bodies", "Muscle fibre cytoplasmic bodies" ; oboInOwl:id "HP:0100303" ; a owl:Class ; rdfs:label "Muscle fiber cytoplasmatic inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0100304 obo:IAO_0000115 "The presence of inclusion bodies within the nucleus of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:39:22Z" ; oboInOwl:hasDbXref "UMLS:C4022156" ; oboInOwl:hasExactSynonym "Muscle fibre intranuclear inclusion bodies" ; oboInOwl:id "HP:0100304" ; a owl:Class ; rdfs:label "Muscle fiber intranuclear inclusion bodies" ; rdfs:subClassOf obo:HP_0100299 . obo:HP_0100305 obo:IAO_0000115 "Ring fibers are formed by a bundle of peripheral myofibrils which are circumferentially oriented such that they encircle the internal portion of the sarcoplasm which is normal in structure and orientation." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:41:11Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:47913008", "UMLS:C0333770" ; oboInOwl:hasExactSynonym "Ring fibres" ; oboInOwl:id "HP:0100305" ; a owl:Class ; rdfs:label "Ring fibers" ; rdfs:subClassOf obo:HP_0004303 . obo:HP_0100306 obo:IAO_0000115 "Subsarcolemmal, eosinophilic glass-like regions in the cytoplasm of muscle fibers. Hyaline bodies show significant reactivity to myofibrillar ATPase after acid pre-incubation and with immunohistochemistry, show intense reactivity with only slow myosin heavy chain. Electron microscopy of the affected areas show a lack of myofibrils and a uniform, finely granular matrix, sometimes suggesting a filamentous nature, containing few scattered nuclei and mitochondria." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:49:13Z" ; oboInOwl:hasDbXref "UMLS:C4022155" ; oboInOwl:hasExactSynonym "Muscle fibre hyaline bodies" ; oboInOwl:id "HP:0100306" ; a owl:Class ; rdfs:label "Muscle fiber hyaline bodies" ; rdfs:subClassOf obo:HP_0100303 . obo:HP_0100307 dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:51:21Z" ; oboInOwl:hasDbXref "UMLS:C4022154" ; oboInOwl:id "HP:0100307" ; a owl:Class ; rdfs:label "Cerebellar hemisphere hypoplasia" ; rdfs:subClassOf obo:HP_0001321 . obo:HP_0100308 obo:IAO_0000115 "Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T02:52:37Z" ; oboInOwl:hasDbXref "UMLS:C4022153" ; oboInOwl:id "HP:0100308" ; a owl:Class ; rdfs:label "Cerebral cortical hemiatrophy" ; rdfs:subClassOf obo:HP_0002120 . obo:HP_0100309 obo:IAO_0000115 "Hemorrhage occurring between the dura mater and the arachnoid mater." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:01:08Z" ; oboInOwl:hasDbXref "MSH:D006408", "SNOMEDCT_US:35486000", "SNOMEDCT_US:95453001", "UMLS:C0018946" ; oboInOwl:hasExactSynonym "Subdural haematoma", "Subdural haemorrhage", "Subdural hematoma" ; oboInOwl:id "HP:0100309" ; a owl:Class ; rdfs:comment "Usually resulting from tears in veins that cross the subdural space, subdural hemorrhage may cause an increase in intracranial pressure, which can cause compression of and damage to delicate brain tissue. Subdural hematomas are often life-threatening when acute, but chronic subdural hematomas are usually not deadly if treated." ; rdfs:label "Subdural hemorrhage" ; rdfs:subClassOf obo:HP_0002170 . obo:HP_0100310 obo:IAO_0000115 "Hemorrhage occurring between the dura mater and the skull." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:05:35Z" ; oboInOwl:hasDbXref "MSH:D006407", "SNOMEDCT_US:428268007", "SNOMEDCT_US:82999001", "UMLS:C0238154" ; oboInOwl:hasExactSynonym "Epidural haematoma", "Epidural haemorrhage", "Epidural hematoma", "Extradural haematoma", "Extradural hematoma" ; oboInOwl:id "HP:0100310" ; a owl:Class ; rdfs:comment "Intracranial bleeding occuring between the dura mater (the tough outer membrane of the central nervous system) and the skull. The dura mater also covers the spine, so epidural bleeds may also occur in the spinal column." ; rdfs:label "Epidural hemorrhage" ; rdfs:subClassOf obo:HP_0002170 . obo:HP_0100311 obo:IAO_0000115 "Bands of scar-like tisssue that hve formed within a cerebral ventricle." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:10:06Z" ; oboInOwl:hasDbXref "UMLS:C4022152" ; oboInOwl:id "HP:0100311" ; a owl:Class ; rdfs:label "Cerebral ventricular adhesions" ; rdfs:subClassOf obo:HP_0002118 . obo:HP_0100312 obo:IAO_0000115 "The presence of a germ cell tumor of the cerebrum." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:17:16Z" ; oboInOwl:hasDbXref "NCIT:C3708", "UMLS:C4022151" ; oboInOwl:id "HP:0100312" ; a owl:Class ; rdfs:label "Cerebral germinoma" ; rdfs:subClassOf obo:HP_0100620, obo:HP_0100835, obo:HP_0100836 . obo:HP_0100313 obo:IAO_0000115 "Cerebral inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:19:05Z" ; oboInOwl:hasDbXref "UMLS:C4022150" ; oboInOwl:id "HP:0100313" ; a owl:Class ; rdfs:comment "A granuloma is a compact (organized) collection of mature mononuclear phagocytes (macrophages and/or epithelioid cells) which may or may not be accompanied by accessory features such as necrosis or the infiltration of other inflammatory leukocytes (Adams DO. The granulomatous inflammatory response. Am J Pathol 1976:84:163-192)." ; rdfs:label "Cerebral granulomatosis" ; rdfs:subClassOf obo:HP_0002060, obo:HP_0002955 . obo:HP_0100314 obo:IAO_0000115 "Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:31:18Z" ; oboInOwl:hasDbXref "UMLS:C4022149" ; oboInOwl:id "HP:0100314" ; a owl:Class ; rdfs:comment "Inclusion bodies are usually derived from proteins." ; rdfs:label "Cerebral inclusion bodies" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0100315 dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:32:14Z" ; oboInOwl:hasDbXref "MSH:D016631", "MSH:D020961", "SNOMEDCT_US:312991009", "SNOMEDCT_US:43127003", "SNOMEDCT_US:80098002", "UMLS:C0085200", "UMLS:C0752347" ; oboInOwl:hasRelatedSynonym "Lewy body disease" ; oboInOwl:id "HP:0100315" ; a owl:Class ; rdfs:label "Lewy bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100316 obo:IAO_0000115 "Intracellular aggregates of actin and actin-associated proteins within nerve cells." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:32:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:57458003", "UMLS:C0521178" ; oboInOwl:id "HP:0100316" ; a owl:Class ; rdfs:label "Hirano bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100317 obo:IAO_0000115 "Presence of abundant argyrophilic grains and coiled bodies on microscopic examination of brain tissue." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:35:26Z" ; oboInOwl:hasDbXref "UMLS:C4021022" ; oboInOwl:hasExactSynonym "Agyrophilic inclusion bodies", "Pick inclusion bodies" ; oboInOwl:id "HP:0100317" ; a owl:Class ; rdfs:label "Argyrophilic inclusion bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100318 obo:IAO_0000115 "An intraneuronal inclusion body composed of acid mucopolysaccharides." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:37:06Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:87554006", "UMLS:C0333749" ; oboInOwl:id "HP:0100318" ; a owl:Class ; rdfs:label "Lafora bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100319 obo:IAO_0000115 "Cerebral eosinophilic, discrete, intracytoplasmatic inclusions of unknown significance." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:39:19Z" ; oboInOwl:hasDbXref "UMLS:C4021021" ; oboInOwl:hasExactSynonym "Cerebral colloid bodies" ; oboInOwl:id "HP:0100319" ; a owl:Class ; rdfs:label "Cerebral hyaline bodies" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100320 obo:IAO_0000115 "Thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:46:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:84605001", "UMLS:C0333731" ; oboInOwl:hasExactSynonym "Rosenthal fibres" ; oboInOwl:id "HP:0100320" ; a owl:Class ; rdfs:label "Rosenthal fibers" ; rdfs:subClassOf obo:HP_0100314 . obo:HP_0100321 obo:IAO_0000115 "An abnormality of the dentate nucleus." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T03:56:48Z" ; oboInOwl:hasDbXref "UMLS:C4022148" ; oboInOwl:hasExactSynonym "Abnormality of the dentate nucleus" ; oboInOwl:id "HP:0100321" ; a owl:Class ; rdfs:label "Abnormal dentate nucleus morphology" ; rdfs:subClassOf obo:HP_0001317 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002132 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100322 dcterms:creator ; oboInOwl:creation_date "2010-08-10T04:00:24Z" ; oboInOwl:hasDbXref "UMLS:C4022147" ; oboInOwl:hasExactSynonym "Absent pyramidal tract" ; oboInOwl:id "HP:0100322" ; a owl:Class ; rdfs:label "Aplasia of the pyramidal tract" ; rdfs:subClassOf obo:HP_0007363 . obo:HP_0100323 obo:IAO_0000115 "Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T04:02:42Z" ; oboInOwl:hasDbXref "UMLS:C4020710", "UMLS:C4022146" ; oboInOwl:hasRelatedSynonym "Aseptic epiphyseal necrosis" ; oboInOwl:id "HP:0100323" ; a owl:Class ; rdfs:comment "Causes may be rapid growth, heredity, trauma or overuse and anatomic conformation." ; rdfs:label "Juvenile aseptic necrosis" ; rdfs:subClassOf obo:HP_0010885 . obo:HP_0100324 obo:IAO_0000115 "A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin." ; dcterms:creator ; oboInOwl:creation_date "2010-08-10T04:14:42Z" ; oboInOwl:hasAlternativeId "HP:0001594", "HP:0007426" ; oboInOwl:hasDbXref "MSH:D012594", "SNOMEDCT_US:403524003", "SNOMEDCT_US:89155008", "UMLS:C0011644", "UMLS:C1274865" ; oboInOwl:hasExactSynonym "Progressive systemic scleroderma", "Pseudoscleroderma" ; oboInOwl:id "HP:0100324" ; a owl:Class ; rdfs:comment "A chronic autoimmune disease characterized by fibrosis (or hardening), vascular alterations, and autoantibodies. Sclerosis of the skin occurs in association with disorders as diverse as dermatomyositis, Werner's syndrome, porphyria, muscle glycogenesis, primary systemic amyloidosis, melorheostosis, and malignancy including the carcinoid syndrome. This term is intended to represent the phenotypic feature scleroderma rather than a particular disease." ; rdfs:label "Scleroderma" ; rdfs:subClassOf obo:HP_0001072 . obo:HP_0100326 obo:IAO_0000115 "Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens." ; dcterms:creator ; oboInOwl:creation_date "2010-09-16T06:00:43Z" ; oboInOwl:hasDbXref "UMLS:C0237653" ; oboInOwl:id "HP:0100326" ; a owl:Class ; rdfs:label "Immunologic hypersensitivity" ; rdfs:subClassOf obo:HP_0010978 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100327 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against cow milk protein." ; dcterms:creator ; oboInOwl:creation_date "2010-09-16T06:03:58Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:15911003", "UMLS:C0266815" ; oboInOwl:hasExactSynonym "Cow milk allergy", "IgE-mediated cow milk allergy", "Immunoglobulin E-mediated cow milk allergy", "Milk allergy" ; oboInOwl:id "HP:0100327" ; a owl:Class ; rdfs:label "Cow milk allergy" ; rdfs:subClassOf obo:HP_0410327 . obo:HP_0100328 obo:IAO_0000115 "Fusion involving carpal and metacarpal bones." ; dcterms:creator ; oboInOwl:creation_date "2010-10-08T03:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4022145" ; oboInOwl:hasExactSynonym "Fused wrist bones and long bones of hand" ; oboInOwl:id "HP:0100328" ; a owl:Class ; rdfs:label "Carpometacarpal synostosis" ; rdfs:subClassOf obo:HP_0009701, obo:HP_0009702 . obo:HP_0100329 dcterms:creator ; oboInOwl:creation_date "2010-10-08T03:53:06Z" ; oboInOwl:hasDbXref "UMLS:C4022144" ; oboInOwl:hasExactSynonym "Fused bones of the midfoot" ; oboInOwl:id "HP:0100329" ; a owl:Class ; rdfs:label "Tarsometatarsal synostosis" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0008368 . obo:HP_0100333 obo:IAO_0000115 "A non-midline cleft of the upper lip on one side only." ; dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:11:32Z" ; oboInOwl:hasAlternativeId "HP:0100331" ; oboInOwl:hasDbXref "SNOMEDCT_US:304067009", "UMLS:C0392006" ; oboInOwl:hasExactSynonym "One sided cleft upper lip", "Unilateral cheiloschisis", "Unilateral cleft upper lip" ; oboInOwl:id "HP:0100333" ; a owl:Class ; rdfs:label "Unilateral cleft lip" ; rdfs:subClassOf obo:HP_0100335 . obo:HP_0100334 dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:16:12Z" ; oboInOwl:hasDbXref "UMLS:C4022143" ; oboInOwl:hasExactSynonym "One sided cleft palate", "Unilateral palatoschisis" ; oboInOwl:id "HP:0100334" ; a owl:Class ; rdfs:label "Unilateral cleft palate" ; rdfs:subClassOf obo:HP_0100338 . obo:HP_0100335 obo:IAO_0000115 "Clefting of the upper lip affecting the lateral portions of the upper lip rather than the midline/median region." ; dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:12:24Z" ; oboInOwl:hasAlternativeId "HP:0010283", "HP:0100332" ; oboInOwl:hasDbXref "UMLS:C4021020" ; oboInOwl:hasExactSynonym "Non-midline cleft of the upper lip", "Paramedian cleft of the upper lip" ; oboInOwl:id "HP:0100335" ; a owl:Class ; rdfs:label "Non-midline cleft lip" ; rdfs:subClassOf obo:HP_0000204 . obo:HP_0100336 obo:IAO_0000115 "A non-midline cleft of the upper lip on the left and right sides." ; dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:13:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:304068004", "UMLS:C0392005" ; oboInOwl:hasExactSynonym "Bilateral cheiloschisis", "Both sided cleft lip", "Right and left cleft lip" ; oboInOwl:id "HP:0100336" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bilateral cleft lip" ; rdfs:subClassOf obo:HP_0100335 . obo:HP_0100337 obo:IAO_0000115 "Nonmidline cleft palate on the left and right sides." ; dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:16:32Z" ; oboInOwl:hasDbXref "UMLS:C3553084" ; oboInOwl:hasExactSynonym "Bilateral palatoschisis", "Right and left cleft palate" ; oboInOwl:id "HP:0100337" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Bilateral cleft palate" ; rdfs:subClassOf obo:HP_0100338 . obo:HP_0100338 dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:16:40Z" ; oboInOwl:hasDbXref "UMLS:C4022142" ; oboInOwl:hasExactSynonym "Paramedian cleft palate" ; oboInOwl:id "HP:0100338" ; a owl:Class ; rdfs:label "Non-midline cleft palate" ; rdfs:subClassOf obo:HP_0000175 . obo:HP_0100339 dcterms:creator ; oboInOwl:creation_date "2010-10-13T04:46:42Z" ; oboInOwl:hasDbXref "UMLS:C4022141" ; oboInOwl:id "HP:0100339" ; a owl:Class ; rdfs:label "Abnormality of the os naviculare pedis" ; rdfs:subClassOf obo:HP_0001850 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100340 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:41:54Z" ; oboInOwl:hasDbXref "UMLS:C4022140" ; oboInOwl:id "HP:0100340" ; a owl:Class ; rdfs:label "Fibular deviation of the 4th toe" ; rdfs:subClassOf obo:HP_0010338 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003634 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100341 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:41:54Z" ; oboInOwl:hasDbXref "UMLS:C4022139" ; oboInOwl:id "HP:0100341" ; a owl:Class ; rdfs:label "Tibial deviation of the 4th toe" ; rdfs:subClassOf obo:HP_0010338 . obo:HP_0100342 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4022138" ; oboInOwl:id "HP:0100342" ; a owl:Class ; rdfs:label "Fibular deviation of the 3rd toe" ; rdfs:subClassOf obo:HP_0010332 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003633 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100343 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:43:52Z" ; oboInOwl:hasDbXref "UMLS:C4022137" ; oboInOwl:id "HP:0100343" ; a owl:Class ; rdfs:label "Tibial deviation of the 3rd toe" ; rdfs:subClassOf obo:HP_0010332 . obo:HP_0100344 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:44:07Z" ; oboInOwl:hasDbXref "UMLS:C4022136" ; oboInOwl:id "HP:0100344" ; a owl:Class ; rdfs:label "Fibular deviation of the 2nd toe" ; rdfs:subClassOf obo:HP_0010326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003632 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100345 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:44:07Z" ; oboInOwl:hasDbXref "UMLS:C4022135" ; oboInOwl:id "HP:0100345" ; a owl:Class ; rdfs:label "Tibial deviation of the 2nd toe" ; rdfs:subClassOf obo:HP_0010326 . obo:HP_0100346 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:44:27Z" ; oboInOwl:hasDbXref "UMLS:C4022134" ; oboInOwl:id "HP:0100346" ; a owl:Class ; rdfs:label "Fibular deviation of the 5th toe" ; rdfs:subClassOf obo:HP_0010344 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003635 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100347 dcterms:creator ; oboInOwl:creation_date "2010-11-11T03:44:27Z" ; oboInOwl:hasDbXref "UMLS:C4022133" ; oboInOwl:id "HP:0100347" ; a owl:Class ; rdfs:label "Tibial deviation of the 5th toe" ; rdfs:subClassOf obo:HP_0010344 . obo:HP_0100348 obo:IAO_0000115 "The proximal interphalangeal joint of the 2nd toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4021019" ; oboInOwl:hasExactSynonym "Camptodactyly of the 2nd toe", "Camptodactyly of the second toe" ; oboInOwl:id "HP:0100348" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 2nd toe" ; rdfs:subClassOf obo:HP_0001836, obo:HP_0010327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100349 obo:IAO_0000115 "The proximal interphalangeal joint of the 3rd toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4021018" ; oboInOwl:hasExactSynonym "Camptodactyly of the 3rd toe" ; oboInOwl:id "HP:0100349" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 3rd toe" ; rdfs:subClassOf obo:HP_0001836, obo:HP_0010333 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100350 obo:IAO_0000115 "The proximal interphalangeal joint of the 4th toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4021017" ; oboInOwl:hasExactSynonym "Camptodactyly of the 4th toe", "Camptodactyly of the fourth toe", "Contracture of the innermost hinge joint of the 4th toe" ; oboInOwl:id "HP:0100350" ; a owl:Class ; rdfs:label "Contracture of the proximal interphalangeal joint of the 4th toe" ; rdfs:subClassOf obo:HP_0001836, obo:HP_0010339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100351 obo:IAO_0000115 "The proximal interphalangeal joint of the fifth toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4021016" ; oboInOwl:hasExactSynonym "Camptodactyly of the 5th toe", "Camptodactyly of the fifth toe" ; oboInOwl:id "HP:0100351" ; a owl:Class ; rdfs:label "Contractures of the proximal interphalangeal joint of the 5th toe" ; rdfs:subClassOf obo:HP_0001836, obo:HP_0010345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001371 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100352 obo:IAO_0000115 "The distal interphalangeal joint of the 2nd toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4021015" ; oboInOwl:hasExactSynonym "Contracture of the distal interphalangeal joint of the second toe" ; oboInOwl:id "HP:0100352" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 2nd toe" ; rdfs:subClassOf obo:HP_0010327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014672 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100353 obo:IAO_0000115 "The distal interphalangeal joint of the 3rd toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022132" ; oboInOwl:id "HP:0100353" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 3rd toe" ; rdfs:subClassOf obo:HP_0010333 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014507 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100354 obo:IAO_0000115 "The distal interphalangeal joint of the 4th toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022131" ; oboInOwl:id "HP:0100354" ; a owl:Class ; rdfs:label "Contracture of the distal interphalangeal joint of the 4th toe" ; rdfs:subClassOf obo:HP_0010339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014674 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100355 obo:IAO_0000115 "The distal interphalangeal joint of the 5th toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022130" ; oboInOwl:hasExactSynonym "Contracture of the outermost hinge joint of the 5th toe" ; oboInOwl:id "HP:0100355" ; a owl:Class ; rdfs:label "Contractures of the distal interphalangeal joint of the 5th toe" ; rdfs:subClassOf obo:HP_0010345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014675 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100356 obo:IAO_0000115 "The joint between the second metatarsal and the proximal phalanx of the 2nd toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022129" ; oboInOwl:id "HP:0100356" ; a owl:Class ; rdfs:label "Contracture of the metatarsophalangeal joint of the 2nd toe" ; rdfs:subClassOf obo:HP_0010327 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007753 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100357 obo:IAO_0000115 "The joint between the third metatarsal and the proximal phalanx of the third toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022128" ; oboInOwl:id "HP:0100357" ; a owl:Class ; rdfs:label "Contracture of the metatarsophalangeal joint of the 3rd toe" ; rdfs:subClassOf obo:HP_0010333 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007756 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100358 obo:IAO_0000115 "The joint between the fourth metatarsal and the proximal phalanx of the fourth toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022127" ; oboInOwl:id "HP:0100358" ; a owl:Class ; rdfs:label "Contracture of the metatarsophalangeal joint of the 4th toe" ; rdfs:subClassOf obo:HP_0010339 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007759 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100359 obo:IAO_0000115 "The joint between the fifth metatarsal and the proximal phalanx of the fifth toe cannot be straightened actively or passively." ; oboInOwl:hasDbXref "UMLS:C4022126" ; oboInOwl:id "HP:0100359" ; a owl:Class ; rdfs:label "Contracture of the metatarsophalangeal joint of the 5th toe" ; rdfs:subClassOf obo:HP_0010345 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0007762 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100360 obo:IAO_0000115 "A limitation in the passive range of motion of a joint of the upper limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin." ; dcterms:creator ; oboInOwl:creation_date "2010-11-11T04:18:29Z" ; oboInOwl:hasDbXref "UMLS:C2750635" ; oboInOwl:hasExactSynonym "Contractures of the joints of the upper limbs" ; oboInOwl:id "HP:0100360" ; a owl:Class ; rdfs:label "Upper-limb joint contracture" ; rdfs:subClassOf obo:HP_0003121 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003839 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100362 oboInOwl:hasDbXref "UMLS:C4022125" ; oboInOwl:hasExactSynonym "Absent digital bone of the 3rd toe" ; oboInOwl:id "HP:0100362" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the 3rd toe" ; rdfs:subClassOf obo:HP_0010331, obo:HP_0010359, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100363 oboInOwl:hasDbXref "UMLS:C4022124" ; oboInOwl:hasExactSynonym "Absent bones of the 4th toe" ; oboInOwl:id "HP:0100363" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the 4th toe" ; rdfs:subClassOf obo:HP_0010337, obo:HP_0010371, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100364 oboInOwl:hasDbXref "UMLS:C4022123" ; oboInOwl:hasExactSynonym "Absent little toe bones", "Absent pinkie toe bones", "Absent pinky toe bones" ; oboInOwl:id "HP:0100364" ; a owl:Class ; rdfs:label "Aplasia of the phalanges of the 5th toe" ; rdfs:subClassOf obo:HP_0010343, obo:HP_0010383, obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100366 obo:IAO_0000115 "Developmental hypoplasia of the phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021014" ; oboInOwl:hasExactSynonym "Hypoplastic/small phalanges of the 3rd toe", "Short 3rd toe bone", "Short phalanx of the third toe" ; oboInOwl:id "HP:0100366" ; a owl:Class ; rdfs:label "Short phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010331, obo:HP_0010359, obo:HP_0010746 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003642 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100367 obo:IAO_0000115 "Developmental hypoplasia of one or more phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4021013" ; oboInOwl:hasExactSynonym "Hypoplastic/small phalanges of the 4th toe", "Short 4th toe bone", "Short phalanx of the fourth toe" ; oboInOwl:id "HP:0100367" ; a owl:Class ; rdfs:label "Short phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010337, obo:HP_0010371, obo:HP_0010746 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003862 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100368 obo:IAO_0000115 "Developmental hypoplasia of one or more phalanx of little toe." ; oboInOwl:hasDbXref "UMLS:C4021012" ; oboInOwl:hasExactSynonym "Hypoplastic/small phalanges of the 5th toe", "Short little toe bone", "Short phalanx of the fifth toe", "Short pinkie toe bone", "Short pinky toe bone" ; oboInOwl:id "HP:0100368" ; a owl:Class ; rdfs:label "Short phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010343, obo:HP_0010383, obo:HP_0010746 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003863 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100369 oboInOwl:hasDbXref "UMLS:C4022122" ; oboInOwl:hasExactSynonym "Absent/small outermost 3rd toe bone", "Absent/underdeveloped outermost 3rd toe bone" ; oboInOwl:id "HP:0100369" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010185, obo:HP_0010331, obo:HP_0010359, obo:HP_0010368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100370 oboInOwl:hasDbXref "UMLS:C4022121" ; oboInOwl:hasExactSynonym "Absent/small outermost bone of 4th toe", "Absent/underdeveloped outermost bone of 4th toe" ; oboInOwl:id "HP:0100370" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010185, obo:HP_0010337, obo:HP_0010371, obo:HP_0010380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100371 oboInOwl:hasDbXref "UMLS:C4022120" ; oboInOwl:hasExactSynonym "Absent/small outermost little toe bone", "Absent/small outermost pinkie toe bone", "Absent/small outermost pinky toe bone", "Absent/underdeveloped outermost pinky toe bone" ; oboInOwl:id "HP:0100371" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010185, obo:HP_0010343, obo:HP_0010383, obo:HP_0010392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100372 oboInOwl:hasDbXref "UMLS:C4022119" ; oboInOwl:hasExactSynonym "Absent/small middle 3rd toe bone", "Absent/underdeveloped middle 3rd toe bone" ; oboInOwl:id "HP:0100372" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010194, obo:HP_0010331, obo:HP_0010359, obo:HP_0010369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100373 oboInOwl:hasDbXref "UMLS:C4022118" ; oboInOwl:hasExactSynonym "Absent/small middle bone of the 4th toe", "Absent/underdeveloped middle bone of the 4th toe" ; oboInOwl:id "HP:0100373" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010194, obo:HP_0010337, obo:HP_0010371, obo:HP_0010381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100374 oboInOwl:hasDbXref "UMLS:C4022117" ; oboInOwl:hasExactSynonym "Absent/small middle 5th toe bone", "Absent/underdeveloped middle bone of little toe", "Absent/underdeveloped middle bone of pinkie toe", "Absent/underdeveloped middle bone of pinky toe" ; oboInOwl:id "HP:0100374" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010194, obo:HP_0010343, obo:HP_0010383, obo:HP_0010393 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100375 obo:IAO_0000115 "Absence (agenesis) or underdevelopment of the proximal phalanx of the 3rd toe." ; oboInOwl:hasDbXref "UMLS:C4022116" ; oboInOwl:hasExactSynonym "Absent/small innermost bone of 3rd toe", "Absent/underdeveloped innermost bone of 3rd toe" ; oboInOwl:id "HP:0100375" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010203, obo:HP_0010331, obo:HP_0010359, obo:HP_0010370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100376 obo:IAO_0000115 "Absence (agenesis) or underdevelopment of the proximal phalanx of the 4th toe." ; oboInOwl:hasDbXref "UMLS:C4022115" ; oboInOwl:hasExactSynonym "Absent/small innermost 4th toe bone", "Absent/underdeveloped innermost 4th toe bone" ; oboInOwl:id "HP:0100376" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010203, obo:HP_0010337, obo:HP_0010371, obo:HP_0010382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100377 obo:IAO_0000115 "Absence (agenesis) or underdevelopment of the proximal phalanx of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4022114" ; oboInOwl:hasExactSynonym "Absent/small innermost little toe bone", "Absent/small innermost pinkie toe bone", "Absent/small innermost pinky toe bone", "Absent/underdeveloped innermost 5th toe bone" ; oboInOwl:id "HP:0100377" ; a owl:Class ; rdfs:label "Aplasia/hypoplasia of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010203, obo:HP_0010343, obo:HP_0010383, obo:HP_0010394 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100378 obo:IAO_0000115 "Developmental aplasia of the distal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021011" ; oboInOwl:hasExactSynonym "Absent distal phalanx of the third toe", "Absent outermost bone of the 3rd toe", "Aplasia of the distal phalanx of the 3rd toe" ; oboInOwl:id "HP:0100378" ; a owl:Class ; rdfs:label "Absent distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010645, obo:HP_0100362, obo:HP_0100369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100379 oboInOwl:hasDbXref "UMLS:C4022113" ; oboInOwl:hasExactSynonym "Absent distal phalanx of the 4th toe", "Absent outermost bone of the 4th toe" ; oboInOwl:id "HP:0100379" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010645, obo:HP_0100363, obo:HP_0100370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100380 oboInOwl:hasDbXref "UMLS:C4022112" ; oboInOwl:hasExactSynonym "Absent outermost bone of the little toe", "Absent outermost bone of the pinkie toe", "Absent outermost bone of the pinky toe" ; oboInOwl:id "HP:0100380" ; a owl:Class ; rdfs:label "Aplasia of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010645, obo:HP_0100364, obo:HP_0100371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100381 obo:IAO_0000115 "Developmental aplasia of the middle phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021010" ; oboInOwl:hasExactSynonym "Absent middle bone of the 3rd toe", "Absent middle phalanx of the third toe", "Aplasia of the middle phalanx of the 3rd toe" ; oboInOwl:id "HP:0100381" ; a owl:Class ; rdfs:label "Absent middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100362, obo:HP_0100372, obo:HP_0100387 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100382 oboInOwl:hasDbXref "UMLS:C4022111" ; oboInOwl:hasExactSynonym "Absent middle bone of 4th toe" ; oboInOwl:id "HP:0100382" ; a owl:Class ; rdfs:label "Aplasia of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100363, obo:HP_0100373, obo:HP_0100387 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100383 oboInOwl:hasDbXref "UMLS:C4022110" ; oboInOwl:hasExactSynonym "Absent middle bone of little toe", "Absent middle bone of pinkie toe", "Absent middle bone of pinky toe" ; oboInOwl:id "HP:0100383" ; a owl:Class ; rdfs:label "Aplasia of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100364, obo:HP_0100374, obo:HP_0100387 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100384 obo:IAO_0000115 "Absence of proximal phalanx of third toe, owing to a congenital defect of development." ; oboInOwl:hasDbXref "UMLS:C4021009" ; oboInOwl:hasExactSynonym "Absent innermost bone of the 3rd toe", "Aplasia of the proximal phalanx of the 3rd toe" ; oboInOwl:id "HP:0100384" ; a owl:Class ; rdfs:label "Absent proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100362, obo:HP_0100375, obo:HP_0100388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100385 oboInOwl:hasDbXref "UMLS:C4022109" ; oboInOwl:hasExactSynonym "Absent innermost bone of the 4th toe" ; oboInOwl:id "HP:0100385" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100363, obo:HP_0100376, obo:HP_0100388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100386 oboInOwl:hasDbXref "UMLS:C4022108" ; oboInOwl:hasExactSynonym "Absent innermost bone of the little toe", "Absent innermost bone of the pinkie toe", "Absent innermost bone of the pinky toe" ; oboInOwl:id "HP:0100386" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100364, obo:HP_0100377, obo:HP_0100388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100387 dcterms:creator ; oboInOwl:creation_date "2010-11-11T04:55:30Z" ; oboInOwl:hasDbXref "UMLS:C4022107" ; oboInOwl:hasExactSynonym "Absent middle toe bones" ; oboInOwl:id "HP:0100387" ; a owl:Class ; rdfs:label "Aplasia of the middle phalanges of the toes" ; rdfs:subClassOf obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003866 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100388 dcterms:creator ; oboInOwl:creation_date "2010-11-11T04:55:30Z" ; oboInOwl:hasDbXref "UMLS:C4022106" ; oboInOwl:hasExactSynonym "Absent innermost toe bones" ; oboInOwl:id "HP:0100388" ; a owl:Class ; rdfs:label "Aplasia of the proximal phalanges of the toes" ; rdfs:subClassOf obo:HP_0010745 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003868 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100389 obo:IAO_0000115 "Developmental hypoplasia of the distal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021008" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 3rd toe", "Short distal phalanx of the third toe", "Short outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100389" ; a owl:Class ; rdfs:label "Short distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100366, obo:HP_0100369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100390 obo:IAO_0000115 "Developmental hypoplasia of the distal phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4021007" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 4th toe", "Short distal phalanx of the fourth toe", "Short outermost bone of the 4th toe" ; oboInOwl:id "HP:0100390" ; a owl:Class ; rdfs:label "Short distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100367, obo:HP_0100370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100391 obo:IAO_0000115 "Developmental hypoplasia of the distal phalanx of little toe." ; oboInOwl:hasDbXref "UMLS:C4021006" ; oboInOwl:hasExactSynonym "Hypoplastic/small distal phalanx of the 5th toe", "Short distal phalanx of the fifth toe", "Short outermost bone of the little toe", "Short outermost bone of the pinkie toe", "Short outermost bone of the pinky toe" ; oboInOwl:id "HP:0100391" ; a owl:Class ; rdfs:label "Short distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100368, obo:HP_0100371 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100392 obo:IAO_0000115 "Developmental hypoplasia of the middle phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021005" ; oboInOwl:hasExactSynonym "Hypoplastic/small middle phalanx of the 3rd toe", "Short middle phalanx of the third toe" ; oboInOwl:id "HP:0100392" ; a owl:Class ; rdfs:label "Short middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100366, obo:HP_0100372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100393 obo:IAO_0000115 "Developmental hypoplasia of the middle phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4021004" ; oboInOwl:hasExactSynonym "Hypoplastic/small middle phalanx of the 4th toe", "Short middle bone of 4th toe", "Short middle phalanx of the fourth toe" ; oboInOwl:id "HP:0100393" ; a owl:Class ; rdfs:label "Short middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100367, obo:HP_0100373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100394 obo:IAO_0000115 "Developmental hypoplasia of the middle phalanx of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4021003" ; oboInOwl:hasExactSynonym "Hypoplastic/small middle phalanx of the 5th toe", "Short middle bone of little toe", "Short middle bone of pinkie toe", "Short middle bone of pinky toe", "Short middle phalanx of the fifth toe" ; oboInOwl:id "HP:0100394" ; a owl:Class ; rdfs:label "Short middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100368, obo:HP_0100374 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100395 obo:IAO_0000115 "Abnormal reduction in length of proximal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4021002" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 3rd toe", "Short proximal phalanx of the third toe" ; oboInOwl:id "HP:0100395" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100366, obo:HP_0100375 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100396 obo:IAO_0000115 "Developmental hypoplasia of the proximal phalanx of fourth toe." ; oboInOwl:hasAlternativeId "HP:0005628" ; oboInOwl:hasDbXref "UMLS:C4021001" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 4th toe", "Short fourth toe proximal phalanx", "Short proximal phalanx of the fourth toe" ; oboInOwl:id "HP:0100396" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100367, obo:HP_0100376 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100397 obo:IAO_0000115 "Developmental hypoplasia of the proximal phalanx of fifth toe." ; oboInOwl:hasDbXref "UMLS:C4021000" ; oboInOwl:hasExactSynonym "Hypoplastic/small proximal phalanx of the 5th toe", "Short innermost bone of little toe", "Short innermost bone of pinkie toe", "Short innermost bone of pinky toe", "Short proximal phalanx of the fifth toe" ; oboInOwl:id "HP:0100397" ; a owl:Class ; rdfs:label "Short proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100368, obo:HP_0100377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100398 obo:IAO_0000115 "Partial or complete duplication of distal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020999" ; oboInOwl:hasExactSynonym "Duplication of the distal phalanx of the third toe", "Duplication of the outermost bone of the 3rd toe", "Partial/complete duplication of the distal phalanx of the 3rd toe" ; oboInOwl:id "HP:0100398" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010367, obo:HP_0010368 . obo:HP_0100399 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020998" ; oboInOwl:hasExactSynonym "Duplication of the distal phalanx of the fourth toe", "Duplication of the outermost bone of the 4th toe", "Partial/complete duplication of the distal phalanx of the 4th toe" ; oboInOwl:id "HP:0100399" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010379, obo:HP_0010380 . obo:HP_0100400 obo:IAO_0000115 "Partial or complete duplication of the distal phalanx of little toe." ; oboInOwl:hasDbXref "UMLS:C4020997" ; oboInOwl:hasExactSynonym "Duplication of the distal phalanx of the fifth toe", "Duplication of the outermost bone of the fifth toe", "Duplication of the outermost bone of the little toe", "Duplication of the outermost bone of the pinkie toe", "Duplication of the outermost bone of the pinky toe", "Partial/complete duplication of the distal phalanx of the 5th toe" ; oboInOwl:id "HP:0100400" ; a owl:Class ; rdfs:label "Duplication of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010391, obo:HP_0010392 . obo:HP_0100401 obo:IAO_0000115 "Partial or complete duplication of middle phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020996" ; oboInOwl:hasExactSynonym "Duplication of the middle bone of the 3rd toe", "Duplication of the middle phalanx of the third toe", "Partial/complete duplication of the middle phalanx of the 3rd toe" ; oboInOwl:id "HP:0100401" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010202, obo:HP_0010367, obo:HP_0010369 . obo:HP_0100402 obo:IAO_0000115 "Partial or complete duplication of middle phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020995" ; oboInOwl:hasExactSynonym "Duplication of the middle bone of the 4th toe", "Duplication of the middle phalanx of the fourth toe", "Partial/complete duplication of the middle phalanx of the 4th toe" ; oboInOwl:id "HP:0100402" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010379, obo:HP_0010381 . obo:HP_0100403 obo:IAO_0000115 "Partial or complete duplication of the middle phalanx of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4020994" ; oboInOwl:hasExactSynonym "Duplication of the middle bone of the little toe", "Duplication of the middle bone of the pinkie toe", "Duplication of the middle bone of the pinky toe", "Duplication of the middle phalanx of the fifth toe", "Partial/complete duplication of the middle phalanx of the 5th toe" ; oboInOwl:id "HP:0100403" ; a owl:Class ; rdfs:label "Duplication of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010202, obo:HP_0010391, obo:HP_0010393 . obo:HP_0100404 obo:IAO_0000115 "Partial or complete duplication of proximal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020993" ; oboInOwl:hasExactSynonym "Duplication of the innermost 3rd toe bone", "Duplication of the proximal phalanx of the third toe", "Partial/complete duplication of the proximal phalanx of the 3rd toe" ; oboInOwl:id "HP:0100404" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010211, obo:HP_0010367, obo:HP_0010370 . obo:HP_0100405 obo:IAO_0000115 "Partial or complete duplication of the proximal phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020992" ; oboInOwl:hasExactSynonym "Duplication of the innermost 4th toe bone", "Duplication of the proximal phalanx of the fourth toe", "Partial/complete duplication of the proximal phalanx of the 4th toe" ; oboInOwl:id "HP:0100405" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010211, obo:HP_0010379, obo:HP_0010382 . obo:HP_0100406 obo:IAO_0000115 "Partial or complete duplication of the proximal phalanx of fifth toe." ; oboInOwl:hasDbXref "UMLS:C4020991" ; oboInOwl:hasExactSynonym "Duplication of the innermost bone of the little toe", "Duplication of the innermost bone of the pinkie toe", "Duplication of the innermost bone of the pinky toe", "Duplication of the proximal phalanx of the fifth toe", "Partial/complete duplication of the proximal phalanx of the 5th toe" ; oboInOwl:id "HP:0100406" ; a owl:Class ; rdfs:label "Duplication of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010391, obo:HP_0010394 . obo:HP_0100407 obo:IAO_0000115 "Complete duplication of distal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020990" ; oboInOwl:hasExactSynonym "Complete duplication of the distal phalanx of the third toe", "Complete duplication of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100407" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100398 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100408 obo:IAO_0000115 "Complete duplication of the distal phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020989" ; oboInOwl:hasExactSynonym "Complete duplication of the distal phalanx of the fourth toe", "Complete duplication of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100408" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100399 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100409 obo:IAO_0000115 "Complete duplication of the distal phalanx of little toe." ; oboInOwl:hasDbXref "UMLS:C4020988" ; oboInOwl:hasExactSynonym "Complete duplication of the distal phalanx of the fifth toe", "Complete duplication of the outermost bone of the little toe", "Complete duplication of the outermost bone of the pinkie toe", "Complete duplication of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100409" ; a owl:Class ; rdfs:label "Complete duplication of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100400 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100410 obo:IAO_0000115 "Complete duplication of middle phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020987" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the 3rd toe", "Complete duplication of the middle phalanx of the third toe" ; oboInOwl:id "HP:0100410" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100401 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100411 obo:IAO_0000115 "Complete duplication of middle phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020986" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the 4th toe", "Complete duplication of the middle phalanx of the fourth toe" ; oboInOwl:id "HP:0100411" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100402 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100412 obo:IAO_0000115 "Complete duplication of the middle phalanx of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4020985" ; oboInOwl:hasExactSynonym "Complete duplication of the middle bone of the little toe", "Complete duplication of the middle bone of the pinkie toe", "Complete duplication of the middle bone of the pinky toe", "Complete duplication of the middle phalanx of the fifth toe" ; oboInOwl:id "HP:0100412" ; a owl:Class ; rdfs:label "Complete duplication of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100403 . obo:HP_0100413 obo:IAO_0000115 "Complete duplication of proximal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4022105" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost 3rd toe bone" ; oboInOwl:id "HP:0100413" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100404 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100414 oboInOwl:hasDbXref "UMLS:C4022104" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost 4th toe bone" ; oboInOwl:id "HP:0100414" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100405 . obo:HP_0100415 obo:IAO_0000115 "Complete duplication of the proximal phalanx of fifth toe." ; oboInOwl:hasDbXref "UMLS:C4020984" ; oboInOwl:hasExactSynonym "Complete duplication of the innermost bone of the little toe", "Complete duplication of the innermost bone of the pinkie toe", "Complete duplication of the innermost bone of the pinky toe", "Complete duplication of the proximal phalanx of the fifth toe" ; oboInOwl:id "HP:0100415" ; a owl:Class ; rdfs:label "Complete duplication of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100406 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100416 obo:IAO_0000115 "Partial duplication of distal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020983" ; oboInOwl:hasExactSynonym "Partial duplication of the distal phalanx of the third toe", "Partial duplication of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100416" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100398 . obo:HP_0100417 obo:IAO_0000115 "Partial duplication of the distal phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020982" ; oboInOwl:hasExactSynonym "Partial duplication of the distal phalanx of the fourth toe", "Partial duplication of the outermost bone of the fourth toe" ; oboInOwl:id "HP:0100417" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100399 . obo:HP_0100418 obo:IAO_0000115 "Partial duplication of the distal phalanx of little toe." ; oboInOwl:hasDbXref "UMLS:C4020981" ; oboInOwl:hasExactSynonym "Partial duplication of the distal phalanx of the fifth toe", "Partial duplication of the outermost bone of the fifth toe", "Partial duplication of the outermost bone of the little toe", "Partial duplication of the outermost bone of the pinkie toe", "Partial duplication of the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100418" ; a owl:Class ; rdfs:label "Partial duplication of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100400 . obo:HP_0100419 obo:IAO_0000115 "Partial duplication of middle phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020980" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of 3rd toe", "Partial duplication of the middle phalanx of the third toe" ; oboInOwl:id "HP:0100419" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100401 . obo:HP_0100420 obo:IAO_0000115 "Partial duplication of middle phalanx of fourth toe." ; oboInOwl:hasDbXref "UMLS:C4020979" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the 4th toe", "Partial duplication of the middle phalanx of the fourth toe" ; oboInOwl:id "HP:0100420" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100402 . obo:HP_0100421 obo:IAO_0000115 "Partial duplication of the middle phalanx of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4020978" ; oboInOwl:hasExactSynonym "Partial duplication of the middle bone of the little toe", "Partial duplication of the middle bone of the pinkie toe", "Partial duplication of the middle bone of the pinky toe", "Partial duplication of the middle phalanx of the fifth toe" ; oboInOwl:id "HP:0100421" ; a owl:Class ; rdfs:label "Partial duplication of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100403 . obo:HP_0100422 obo:IAO_0000115 "Partial duplication of proximal phalanx of third toe." ; oboInOwl:hasDbXref "UMLS:C4020977" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bone of 3rd toe", "Partial duplication of the proximal phalanx of the third toe" ; oboInOwl:id "HP:0100422" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100404 . obo:HP_0100423 oboInOwl:hasDbXref "UMLS:C4022103" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bone of 4th toe" ; oboInOwl:id "HP:0100423" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100405 . obo:HP_0100424 obo:IAO_0000115 "Partial duplication of the proximal phalanx of fifth toe." ; oboInOwl:hasDbXref "UMLS:C4020976" ; oboInOwl:hasExactSynonym "Partial duplication of the innermost bone of the little toe", "Partial duplication of the innermost bone of the pinkie toe", "Partial duplication of the innermost bone of the pinky toe", "Partial duplication of the proximal phalanx of the fifth toe" ; oboInOwl:id "HP:0100424" ; a owl:Class ; rdfs:label "Partial duplication of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100406 . obo:HP_0100425 oboInOwl:hasDbXref "UMLS:C4022102" ; oboInOwl:hasExactSynonym "Broad middle 3rd toe bone" ; oboInOwl:id "HP:0100425" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010195, obo:HP_0010360, obo:HP_0010369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100426 oboInOwl:hasDbXref "UMLS:C4022101" ; oboInOwl:hasExactSynonym "Broad middle 4th toe bone" ; oboInOwl:id "HP:0100426" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010195, obo:HP_0010372, obo:HP_0010381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100427 oboInOwl:hasDbXref "UMLS:C4022100" ; oboInOwl:hasExactSynonym "Broad middle bone of the little toe", "Broad middle bone of the pinkie toe", "Broad middle bone of the pinky toe" ; oboInOwl:id "HP:0100427" ; a owl:Class ; rdfs:label "Broad middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010195, obo:HP_0010384, obo:HP_0010393 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100428 oboInOwl:hasDbXref "UMLS:C4022099" ; oboInOwl:hasExactSynonym "Wide innermost bone of 3rd toe" ; oboInOwl:id "HP:0100428" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010204, obo:HP_0010360, obo:HP_0010370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100429 oboInOwl:hasDbXref "UMLS:C4022098" ; oboInOwl:hasExactSynonym "Wide innermost bone of 4th toe" ; oboInOwl:id "HP:0100429" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010204, obo:HP_0010372, obo:HP_0010382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100430 oboInOwl:hasDbXref "UMLS:C4022097" ; oboInOwl:hasExactSynonym "Broad innermost bone of the little toe", "Broad innermost bone of the pinkie toe", "Broad innermost bone of the pinky toe" ; oboInOwl:id "HP:0100430" ; a owl:Class ; rdfs:label "Broad proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010204, obo:HP_0010384, obo:HP_0010394 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100431 oboInOwl:hasDbXref "UMLS:C4022096" ; oboInOwl:hasExactSynonym "Broad outermost bone of the 3rd toe", "Wide outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100431" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010186, obo:HP_0010360, obo:HP_0010368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100432 oboInOwl:hasDbXref "UMLS:C4022095" ; oboInOwl:hasExactSynonym "Broad outermost bone of the 4th toe", "Wide outermost bone of the 4th toe" ; oboInOwl:id "HP:0100432" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010186, obo:HP_0010372, obo:HP_0010380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100433 oboInOwl:hasDbXref "UMLS:C4022094" ; oboInOwl:hasExactSynonym "Broad outermost bone of the 5th toe", "Wide outermost bone of the little toe", "Wide outermost bone of the pinkie toe", "Wide outermost bone of the pinky toe" ; oboInOwl:id "HP:0100433" ; a owl:Class ; rdfs:label "Broad distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010186, obo:HP_0010384, obo:HP_0010392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100434 obo:IAO_0000115 "An abnormal morphology of the middle phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022093" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of the 3rd toe" ; oboInOwl:id "HP:0100434" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010361 . obo:HP_0100435 obo:IAO_0000115 "An abnormal morphology of the middle phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022092" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of the 4th toe" ; oboInOwl:id "HP:0100435" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010373 . obo:HP_0100436 obo:IAO_0000115 "An abnormal morphology of the middle phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022091" ; oboInOwl:hasExactSynonym "Bullet-shaped middle bone of the little toe", "Bullet-shaped middle bone of the pinkie toe", "Bullet-shaped middle bone of the pinky toe" ; oboInOwl:id "HP:0100436" ; a owl:Class ; rdfs:label "Bullet-shaped middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010385 . obo:HP_0100437 obo:IAO_0000115 "An abnormal morphology of the proximal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022090" ; oboInOwl:hasExactSynonym "Bullet-shaped proximal bone of the 3rd toe" ; oboInOwl:id "HP:0100437" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010205, obo:HP_0010361 . obo:HP_0100438 obo:IAO_0000115 "An abnormal morphology of the proximal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022089" ; oboInOwl:hasExactSynonym "Bullet-shaped proximal bone of the 4th toe" ; oboInOwl:id "HP:0100438" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010205, obo:HP_0010373 . obo:HP_0100439 obo:IAO_0000115 "An abnormal morphology of the proximal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022088" ; oboInOwl:hasExactSynonym "Bullet-shaped innermost bone of little toe", "Bullet-shaped innermost bone of pinkie toe", "Bullet-shaped innermost bone of pinky toe" ; oboInOwl:id "HP:0100439" ; a owl:Class ; rdfs:label "Bullet-shaped proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010205, obo:HP_0010385 . obo:HP_0100440 obo:IAO_0000115 "An abnormal morphology of the distal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022087" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100440" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010361 . obo:HP_0100441 obo:IAO_0000115 "An abnormal morphology of the distal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022086" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the 4th toe" ; oboInOwl:id "HP:0100441" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010373 . obo:HP_0100442 obo:IAO_0000115 "An abnormal morphology of the distal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." ; oboInOwl:hasDbXref "UMLS:C4022085" ; oboInOwl:hasExactSynonym "Bullet-shaped outermost bone of the little toe", "Bullet-shaped outermost bone of the pinkie toe", "Bullet-shaped outermost bone of the pinky toe" ; oboInOwl:id "HP:0100442" ; a owl:Class ; rdfs:label "Bullet-shaped distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010385 . obo:HP_0100443 obo:IAO_0000115 "A deviation from the normal straight form of the middle phalanx of the third toe." ; oboInOwl:hasDbXref "UMLS:C4022084" ; oboInOwl:hasExactSynonym "Curved middle bone of 3rd toe" ; oboInOwl:id "HP:0100443" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010197, obo:HP_0010362, obo:HP_0010369 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100444 obo:IAO_0000115 "A deviation from the normal straight form of the middle phalanx of the fourth toe." ; oboInOwl:hasDbXref "UMLS:C4022083" ; oboInOwl:hasExactSynonym "Curved middle bone of 4th toe" ; oboInOwl:id "HP:0100444" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010197, obo:HP_0010374, obo:HP_0010381 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004326 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100445 obo:IAO_0000115 "A deviation from the normal straight form of the middle phalanx of the fifth toe." ; oboInOwl:hasDbXref "UMLS:C4022082" ; oboInOwl:hasExactSynonym "Curved middle bone of little toe", "Curved middle bone of pinkie toe", "Curved middle bone of pinky toe" ; oboInOwl:id "HP:0100445" ; a owl:Class ; rdfs:label "Curved middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010197, obo:HP_0010386, obo:HP_0010393 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004327 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100446 obo:IAO_0000115 "A deviation from the normal straight form of the proximal phalanx of the third toe." ; oboInOwl:hasDbXref "UMLS:C4022081" ; oboInOwl:hasExactSynonym "Curved innermost bone of 3rd toe" ; oboInOwl:id "HP:0100446" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010206, obo:HP_0010362, obo:HP_0010370 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004334 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100447 obo:IAO_0000115 "A deviation from the normal straight form of the proximal phalanx of the fourth toe." ; oboInOwl:hasDbXref "UMLS:C4022080" ; oboInOwl:hasExactSynonym "Curved innermost bone of the 4th toe" ; oboInOwl:id "HP:0100447" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010206, obo:HP_0010374, obo:HP_0010382 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004335 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100448 obo:IAO_0000115 "A deviation from the normal straight form of the proximal phalanx of the fifth toe." ; oboInOwl:hasDbXref "UMLS:C4022079" ; oboInOwl:hasExactSynonym "Curved innermost little toe bone", "Curved innermost pinkie toe bone", "Curved innermost pinky toe bone" ; oboInOwl:id "HP:0100448" ; a owl:Class ; rdfs:label "Curved proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010206, obo:HP_0010386, obo:HP_0010394 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100449 obo:IAO_0000115 "A deviation from the normal straight form of the distal phalanx of the third toe." ; oboInOwl:hasDbXref "UMLS:C4022078" ; oboInOwl:hasExactSynonym "Curved outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100449" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010188, obo:HP_0010362, obo:HP_0010368 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004317 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100450 obo:IAO_0000115 "A deviation from the normal straight form of the distal phalanx of the fourth toe." ; oboInOwl:hasDbXref "UMLS:C4022077" ; oboInOwl:hasExactSynonym "Curved outermost bone of the 4th toe" ; oboInOwl:id "HP:0100450" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010188, obo:HP_0010374, obo:HP_0010380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100451 obo:IAO_0000115 "A deviation from the normal straight form of the distal phalanx of the fifth toe." ; oboInOwl:hasDbXref "UMLS:C4022076" ; oboInOwl:hasExactSynonym "Curved outermost bone of the little toe", "Curved outermost bone of the pinkie toe", "Curved outermost bone of the pinky toe" ; oboInOwl:id "HP:0100451" ; a owl:Class ; rdfs:label "Curved distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010188, obo:HP_0010386, obo:HP_0010392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004319 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100452 oboInOwl:hasDbXref "UMLS:C4022075" ; oboInOwl:id "HP:0100452" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010363 . obo:HP_0100453 oboInOwl:hasDbXref "UMLS:C4022074" ; oboInOwl:id "HP:0100453" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010375 . obo:HP_0100454 oboInOwl:hasDbXref "UMLS:C4022073" ; oboInOwl:id "HP:0100454" ; a owl:Class ; rdfs:label "Osteolytic defects of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010387 . obo:HP_0100455 oboInOwl:hasDbXref "UMLS:C4022072" ; oboInOwl:id "HP:0100455" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010363 . obo:HP_0100456 oboInOwl:hasDbXref "UMLS:C4022071" ; oboInOwl:id "HP:0100456" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010375 . obo:HP_0100457 oboInOwl:hasDbXref "UMLS:C4022070" ; oboInOwl:id "HP:0100457" ; a owl:Class ; rdfs:label "Osteolytic defects of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010387 . obo:HP_0100458 oboInOwl:hasDbXref "UMLS:C4022069" ; oboInOwl:hasExactSynonym "Osteolytic defects of the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100458" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010363 . obo:HP_0100459 oboInOwl:hasDbXref "UMLS:C4022068" ; oboInOwl:hasExactSynonym "Osteolytic defects of the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100459" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010375 . obo:HP_0100460 oboInOwl:hasDbXref "UMLS:C4022067" ; oboInOwl:hasExactSynonym "Osteolytic defects of the outermost bone of the 5th toe" ; oboInOwl:id "HP:0100460" ; a owl:Class ; rdfs:label "Osteolytic defects of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010387 . obo:HP_0100461 oboInOwl:hasDbXref "UMLS:C4022066" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100461" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010199, obo:HP_0010364, obo:HP_0100936 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100462 obo:IAO_0000115 "Uneven increase in bone density of the middle phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022065" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in middle bone of the 4th toe" ; oboInOwl:id "HP:0100462" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010199, obo:HP_0010376, obo:HP_0100937 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100463 obo:IAO_0000115 "Uneven increase in bone density of the middle phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022064" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the middle bone of the little toe", "Uneven increase in bone density in the middle bone of the pinkie toe", "Uneven increase in bone density in the middle bone of the pinky toe" ; oboInOwl:id "HP:0100463" ; a owl:Class ; rdfs:label "Patchy sclerosis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010199, obo:HP_0010388, obo:HP_0100938 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100464 oboInOwl:hasDbXref "UMLS:C4022063" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100464" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010208, obo:HP_0010364, obo:HP_0100932 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100465 obo:IAO_0000115 "Uneven increase in bone density of the proximal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022062" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100465" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010208, obo:HP_0010376, obo:HP_0100933 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100466 obo:IAO_0000115 "Uneven increase in bone density of the proximal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022061" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the innermost bone of the little toe", "Uneven increase in bone density in the innermost bone of the pinkie toe", "Uneven increase in bone density in the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100466" ; a owl:Class ; rdfs:label "Patchy sclerosis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010208, obo:HP_0010388, obo:HP_0100934 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100467 oboInOwl:hasDbXref "UMLS:C4022060" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100467" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010190, obo:HP_0010364, obo:HP_0100940 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100468 obo:IAO_0000115 "Uneven increase in bone density of the distal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022059" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100468" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010190, obo:HP_0010376, obo:HP_0100941 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100469 obo:IAO_0000115 "Patchy (irregular) increase in bone density of the distal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." ; oboInOwl:hasDbXref "UMLS:C4022058" ; oboInOwl:hasExactSynonym "Uneven increase in bone density in the outermost little toe bone", "Uneven increase in bone density in the outermost pinkie toe bone", "Uneven increase in bone density in the outermost pinky toe bone" ; oboInOwl:id "HP:0100469" ; a owl:Class ; rdfs:label "Patchy sclerosis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010190, obo:HP_0010388, obo:HP_0100942 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0001608 ] ) ] ] . obo:HP_0100470 oboInOwl:hasDbXref "UMLS:C4022057" ; oboInOwl:hasExactSynonym "Fused middle bones of 3rd toe" ; oboInOwl:id "HP:0100470" ; a owl:Class ; rdfs:label "Symphalangism affecting the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010365 . obo:HP_0100471 oboInOwl:hasDbXref "UMLS:C4022056" ; oboInOwl:hasExactSynonym "Fused middle bones of 4th toe" ; oboInOwl:id "HP:0100471" ; a owl:Class ; rdfs:label "Symphalangism affecting the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010377 . obo:HP_0100472 oboInOwl:hasDbXref "UMLS:C4022055" ; oboInOwl:hasExactSynonym "Fused middle bones of 5th toe" ; oboInOwl:id "HP:0100472" ; a owl:Class ; rdfs:label "Symphalangism affecting the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010389 . obo:HP_0100473 oboInOwl:hasDbXref "UMLS:C4022054" ; oboInOwl:hasExactSynonym "Fused innermost bone of 3rd toe" ; oboInOwl:id "HP:0100473" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0010365 . obo:HP_0100474 oboInOwl:hasDbXref "UMLS:C4022053" ; oboInOwl:hasExactSynonym "Fused innermost bones of 4th toe" ; oboInOwl:id "HP:0100474" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0010377 . obo:HP_0100475 oboInOwl:hasDbXref "UMLS:C4022052" ; oboInOwl:hasExactSynonym "Fused innermost bone of little toe", "Fused innermost bone of pinkie toe", "Fused innermost bone of pinky toe" ; oboInOwl:id "HP:0100475" ; a owl:Class ; rdfs:label "Symphalangism affecting the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010389 . obo:HP_0100476 oboInOwl:hasDbXref "UMLS:C4022051" ; oboInOwl:hasExactSynonym "Fused outermost bone of 3rd toe" ; oboInOwl:id "HP:0100476" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0001859, obo:HP_0100470 . obo:HP_0100477 oboInOwl:hasDbXref "UMLS:C4022050" ; oboInOwl:hasExactSynonym "Fused outermost bone of the 4th toe" ; oboInOwl:id "HP:0100477" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0001859, obo:HP_0100471 . obo:HP_0100478 oboInOwl:hasDbXref "UMLS:C4022049" ; oboInOwl:hasExactSynonym "Fused outermost bones of the little toe", "Fused outermost bones of the pinkie toe", "Fused outermost bones of the pinky toe" ; oboInOwl:id "HP:0100478" ; a owl:Class ; rdfs:label "Symphalangism affecting the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0001859, obo:HP_0100472 . obo:HP_0100480 obo:IAO_0000115 "Bony fusion of the middle and proximal phalanges of the 3rd toe." ; oboInOwl:hasDbXref "UMLS:C4020975" ; oboInOwl:hasExactSynonym "Fused innermost and middle bones of 3rd toe", "Symphalangism of the middle and proximal phalanges of the 3rd toe" ; oboInOwl:id "HP:0100480" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 3rd toe" ; rdfs:subClassOf obo:HP_0010378, obo:HP_0100237, obo:HP_0100470, obo:HP_0100473 . obo:HP_0100481 obo:IAO_0000115 "Bony fusion of the middle and proximal phalanges of the 4th toe." ; oboInOwl:hasDbXref "UMLS:C4020974" ; oboInOwl:hasExactSynonym "Fused innermost and middle bones of 4th toe", "Symphalangism of the middle and proximal phalanges of the 4th toe" ; oboInOwl:id "HP:0100481" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 4th toe" ; rdfs:subClassOf obo:HP_0010390, obo:HP_0100237, obo:HP_0100471, obo:HP_0100474 . obo:HP_0100482 obo:IAO_0000115 "Bony fusion of the middle and proximal phalanges of the 5th toe." ; oboInOwl:hasDbXref "UMLS:C4020973" ; oboInOwl:hasExactSynonym "Fused innermost and middle little toe bones", "Fused innermost and middle pinkie toe bones", "Fused innermost and middle pinky toe bones", "Symphalangism of the middle and proximal phalanges of the 5th toe" ; oboInOwl:id "HP:0100482" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 5th toe" ; rdfs:subClassOf obo:HP_0010366, obo:HP_0100237, obo:HP_0100472, obo:HP_0100475 . obo:HP_0100483 oboInOwl:hasDbXref "UMLS:C4022048" ; oboInOwl:hasExactSynonym "Fused innermost bone of 2nd toe with the 2nd long bone of foot" ; oboInOwl:id "HP:0100483" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 2nd toe with the 2nd metatarsal" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0010378, obo:HP_0010401 . obo:HP_0100484 oboInOwl:hasDbXref "UMLS:C4022047" ; oboInOwl:hasExactSynonym "Fused innermost bones of third toe with 3rd long bone of foot" ; oboInOwl:id "HP:0100484" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 3rd toe with the 3rd metatarsal" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0010390, obo:HP_0100473 . obo:HP_0100485 oboInOwl:hasDbXref "UMLS:C4022046" ; oboInOwl:hasExactSynonym "Fused innermost bone of the 4th toe with 4th long bone of foot" ; oboInOwl:id "HP:0100485" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 4th toe with the 4th metatarsal" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0010366, obo:HP_0100474 . obo:HP_0100486 oboInOwl:hasDbXref "UMLS:C4022045" ; oboInOwl:hasExactSynonym "Fused innermost pinky toe bone with the 5th long bone of foot" ; oboInOwl:id "HP:0100486" ; a owl:Class ; rdfs:label "Symphalangism of the proximal phalanx of the 5th toe with the 5th metatarsal" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0010378, obo:HP_0100475 . obo:HP_0100487 oboInOwl:hasDbXref "UMLS:C4022044" ; oboInOwl:hasExactSynonym "Triangular shaped outermost bone of the little toe", "Triangular shaped outermost bone of the pinkie toe", "Triangular shaped outermost bone of the pinky toe" ; oboInOwl:id "HP:0100487" ; a owl:Class ; rdfs:label "Triangular shaped distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0010390 . obo:HP_0100488 dcterms:creator ; oboInOwl:creation_date "2010-11-18T06:24:21Z" ; oboInOwl:hasDbXref "UMLS:C4022043" ; oboInOwl:hasExactSynonym "Fusion of the innermost big toe bone with the 1st long bone of foot" ; oboInOwl:id "HP:0100488" ; a owl:Class ; rdfs:label "Synostosis of the proximal phalanx of the hallux with the 1st metatarsal" ; rdfs:subClassOf obo:HP_0001440, obo:HP_0010073, obo:HP_0010091, obo:HP_0010209, obo:HP_0100237 . obo:HP_0100489 obo:IAO_0000115 "Bony fusion of the middle and proximal phalanges of the 2nd toe." ; dcterms:creator ; oboInOwl:creation_date "2010-11-18T06:49:16Z" ; oboInOwl:hasAlternativeId "HP:0100479" ; oboInOwl:hasDbXref "UMLS:C4020972" ; oboInOwl:hasExactSynonym "Fused middle and innermost bones of 2nd toe", "Symphalangism of the middle and proximal phalanges of the 2nd toe" ; oboInOwl:id "HP:0100489" ; a owl:Class ; rdfs:label "Proximal/middle symphalangism of 2nd toe" ; rdfs:subClassOf obo:HP_0010366, obo:HP_0010401, obo:HP_0010410, obo:HP_0100237 . obo:HP_0100490 obo:IAO_0000115 "The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers cannot be extended to 180 degrees by either active or passive extension." ; dcterms:creator ; oboInOwl:creation_date "2010-12-14T10:46:57Z" ; oboInOwl:hasAlternativeId "HP:0005651", "HP:0005662", "HP:0005713", "HP:0005801", "HP:0005821", "HP:0006195", "HP:0006218", "HP:0006240", "HP:0009698" ; oboInOwl:hasDbXref "SNOMEDCT_US:202281000", "UMLS:C0409348" ; oboInOwl:hasExactSynonym "Camptodactyly of hands", "Camptodactyly of proximal interphalangeal joint", "Contractures of the proximal interphalangeal joints of the fingers", "Flexion contractures of proximal interphalangeal joints", "Permanent flexion of the finger", "Proximal interphalangeal finger joint contractures" ; oboInOwl:id "HP:0100490" ; a owl:Class ; rdfs:comment "Note that some restrict the use of the term to inability to extend the proximal interphalangeal joint of the fifth finger. We do not restrict the term in this way. This term should not be used if the patient has Clenched hand. A similar effect can be created by radial angulation within the distal phalanx with thickening of the epiphysis, which is called Kirner deformity or dystelephalangy. The affected digits should be specified." ; rdfs:label "Camptodactyly of finger" ; rdfs:subClassOf obo:HP_0001220, obo:HP_0006261, obo:HP_0012385 . obo:HP_0100491 dcterms:creator ; oboInOwl:creation_date "2010-12-14T10:58:11Z" ; oboInOwl:hasAlternativeId "HP:0100239" ; oboInOwl:hasDbXref "UMLS:C4020971" ; oboInOwl:hasExactSynonym "Abnormality of lower limb joint", "Abnormality of the joints of the lower limbs" ; oboInOwl:id "HP:0100491" ; a owl:Class ; rdfs:label "Abnormality of lower limb joint" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0002814 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100492 obo:IAO_0100001 "HP:0008366" ; oboInOwl:id "HP:0100492" ; a owl:Class ; rdfs:label "obsolete Joint contractures involving the joints of the feet" ; owl:deprecated true . obo:HP_0100493 obo:IAO_0000115 "A decreased concentration of ammonia in the blood." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T03:54:51Z" ; oboInOwl:hasDbXref "UMLS:C4022041" ; oboInOwl:id "HP:0100493" ; a owl:Class ; rdfs:label "Hypoammonemia" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100494 obo:IAO_0000115 "Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:02:08Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:397017008", "UMLS:C1301149" ; oboInOwl:hasExactSynonym "Abnormality of mast cells", "Abnormality of mastocytes" ; oboInOwl:id "HP:0100494" ; a owl:Class ; rdfs:comment "Mast cells (or mastocytes) can be found in several types of tissues and contain many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens. Mast cells possess a non-lobed nucleus and can work with basophils in the immune defense against worms. Their cell membrane is covered with Fc recepros that may be attached to class E antibodies." ; rdfs:label "Abnormal mast cell morphology" ; rdfs:subClassOf obo:HP_0001911 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100495 obo:IAO_0000115 "The presence of an increased number of mast cells and CD34+ mast cell precursors in the body." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:06:36Z" ; oboInOwl:hasDbXref "MSH:D008415", "SNOMEDCT_US:125541005", "SNOMEDCT_US:397007003", "UMLS:C0024899" ; oboInOwl:id "HP:0100495" ; a owl:Class ; rdfs:label "Mastocytosis" ; rdfs:subClassOf obo:HP_0100494 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100496 dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:13:00Z" ; oboInOwl:hasDbXref "UMLS:C4022040" ; oboInOwl:hasExactSynonym "Abnormality of the vitamin B3 metabolism" ; oboInOwl:id "HP:0100496" ; a owl:Class ; rdfs:comment "Vitamin B3 is also known as nicotinic acid, vitamin PP or Niacin and is one of the forty to eighty essential human nutrients." ; rdfs:label "Abnormality of the vitamin B3 metabolism" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0100497 dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:14:51Z" ; oboInOwl:hasDbXref "MSH:D010383", "SNOMEDCT_US:418186002", "SNOMEDCT_US:418279001", "UMLS:C0030783" ; oboInOwl:hasExactSynonym "Vitamin B3 deficiency" ; oboInOwl:id "HP:0100497" ; a owl:Class ; rdfs:label "Vitamin B3 deficiency" ; rdfs:subClassOf obo:HP_0100496 . obo:HP_0100498 dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:25:31Z" ; oboInOwl:hasDbXref "UMLS:C4022039" ; oboInOwl:id "HP:0100498" ; a owl:Class ; rdfs:label "Deviation of toes" ; rdfs:subClassOf obo:HP_0001780 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002175 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100499 dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:25:59Z" ; oboInOwl:hasDbXref "UMLS:C3806533" ; oboInOwl:hasExactSynonym "Medial deviation of toes" ; oboInOwl:id "HP:0100499" ; a owl:Class ; rdfs:label "Tibial deviation of toes" ; rdfs:subClassOf obo:HP_0100498 . obo:HP_0100500 dcterms:creator ; oboInOwl:creation_date "2010-12-17T04:26:14Z" ; oboInOwl:hasDbXref "UMLS:C4020970" ; oboInOwl:hasExactSynonym "Lateral deviation of toes" ; oboInOwl:id "HP:0100500" ; a owl:Class ; rdfs:label "Fibular deviation of toes" ; rdfs:subClassOf obo:HP_0100498 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002176 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001466 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100501 obo:IAO_0000115 "An increased susceptibility to bronchiolitis as manifested by a history of recurrent bronchiolitis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T05:58:08Z" ; oboInOwl:hasDbXref "UMLS:C4015136" ; oboInOwl:id "HP:0100501" ; a owl:Class ; rdfs:label "Recurrent bronchiolitis" ; rdfs:subClassOf obo:HP_0002837 . obo:HP_0100502 dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:00:43Z" ; oboInOwl:hasDbXref "MSH:D014806", "SNOMEDCT_US:190634004", "UMLS:C0042847" ; oboInOwl:hasExactSynonym "Vitamin B12 deficiency" ; oboInOwl:id "HP:0100502" ; a owl:Class ; rdfs:label "Vitamin B12 deficiency" ; rdfs:subClassOf obo:HP_0040126 . obo:HP_0100503 obo:IAO_0000115 "A reduced concentration of vitamin B1." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:13:04Z" ; oboInOwl:hasDbXref "MSH:D013832", "SNOMEDCT_US:399357009", "UMLS:C0039841" ; oboInOwl:hasExactSynonym "Reduced blood thiamine level", "Vitamin B1 deficiency" ; oboInOwl:id "HP:0100503" ; a owl:Class ; rdfs:label "Low levels of vitamin B1" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0100504 obo:IAO_0000115 "A reduced concentration of vitamin B2." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:13:04Z" ; oboInOwl:hasDbXref "MSH:D012257", "SNOMEDCT_US:20307000", "UMLS:C0035528" ; oboInOwl:hasExactSynonym "Riboflavin deficiency", "Vitamin B2 deficiency" ; oboInOwl:id "HP:0100504" ; a owl:Class ; rdfs:label "Low levels of vitamin B2" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0100505 obo:IAO_0000115 "A reduced concentration of vitamin B5." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:13:04Z" ; oboInOwl:hasDbXref "UMLS:C4022038" ; oboInOwl:hasExactSynonym "Vitamin B5 deficiency" ; oboInOwl:id "HP:0100505" ; a owl:Class ; rdfs:label "Low levels of vitamin B5" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0100506 obo:IAO_0000115 "A reduced concentration of vitamin B8." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:13:04Z" ; oboInOwl:hasDbXref "UMLS:C4022037" ; oboInOwl:hasExactSynonym "Vitamin B8 deficiency" ; oboInOwl:id "HP:0100506" ; a owl:Class ; rdfs:label "Low levels of vitamin B8" ; rdfs:subClassOf obo:HP_0004340 . obo:HP_0100507 obo:IAO_0000115 "A reduced circulating concentration of folic acid, which is also known as vitamin B9." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:13:04Z" ; oboInOwl:hasDbXref "MSH:D005494", "SNOMEDCT_US:190633005", "UMLS:C0016412" ; oboInOwl:hasExactSynonym "Folate deficiency", "Vitamin B9 deficiency" ; oboInOwl:id "HP:0100507" ; a owl:Class ; rdfs:label "Reduced blood folate concentration" ; rdfs:subClassOf obo:HP_0040087 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100508 obo:IAO_0000115 "An anomaly in the metabolism of a vitamin." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:17:22Z" ; oboInOwl:hasDbXref "UMLS:C4022036" ; oboInOwl:hasExactSynonym "Abnormality of vitamin metabolism" ; oboInOwl:id "HP:0100508" ; a owl:Class ; rdfs:comment "Vitamins are organic substances that are essential in minute quantities and not produced within the body, instead being present in natural foodstuffs. Vitamins act as coenzymes or precursors of coenzymes in the regulation of metabolic processes." ; rdfs:label "Abnormality of vitamin metabolism" ; rdfs:subClassOf obo:HP_0032245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0006766 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100509 dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:18:32Z" ; oboInOwl:hasDbXref "UMLS:C4021863" ; oboInOwl:hasExactSynonym "Abnormality of vitamin C metabolism" ; oboInOwl:id "HP:0100509" ; a owl:Class ; rdfs:label "Abnormality of vitamin C metabolism" ; rdfs:subClassOf obo:HP_0100508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0019852 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100510 obo:IAO_0000115 "A reduced concentration of Vitamin C." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:18:50Z" ; oboInOwl:hasDbXref "MSH:D001206", "SNOMEDCT_US:76169001", "UMLS:C0003969" ; oboInOwl:hasExactSynonym "Vitamin C deficiency" ; oboInOwl:id "HP:0100510" ; a owl:Class ; rdfs:label "Low levels of vitamin C" ; rdfs:subClassOf obo:HP_0100509 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_21241 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100511 dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:19:15Z" ; oboInOwl:hasDbXref "UMLS:C4022035" ; oboInOwl:hasExactSynonym "Abnormality of vitamin D metabolism" ; oboInOwl:id "HP:0100511" ; a owl:Class ; rdfs:label "Abnormality of vitamin D metabolism" ; rdfs:subClassOf obo:HP_0100508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042359 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100512 obo:IAO_0000115 "A reduced concentration of Vitamin D." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:19:35Z" ; oboInOwl:hasDbXref "MSH:D014808", "SNOMEDCT_US:34713006", "UMLS:C0042870" ; oboInOwl:hasExactSynonym "Deficient in vitamin D", "Vitamin D deficiency" ; oboInOwl:id "HP:0100512" ; a owl:Class ; rdfs:label "Low levels of vitamin D" ; rdfs:subClassOf obo:HP_0100511 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_27300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100513 obo:IAO_0000115 "A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:20:12Z" ; oboInOwl:hasDbXref "MSH:D014811", "SNOMEDCT_US:54137008", "UMLS:C0042875" ; oboInOwl:hasExactSynonym "Alpha-tocopherol deficiency", "Low levels of vitamin E", "Vitamin E deficiency" ; oboInOwl:id "HP:0100513" ; a owl:Class ; rdfs:label "Decreased circulating vitamin E concentration" ; rdfs:subClassOf obo:HP_0100514 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_33234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100514 obo:IAO_0000115 "Concentration of vitamin E in the blood circulation outside of normal limits." ; dcterms:creator ; oboInOwl:creation_date "2010-12-17T06:20:30Z" ; oboInOwl:hasDbXref "UMLS:C4022034" ; oboInOwl:id "HP:0100514" ; a owl:Class ; rdfs:label "Abnormal circulating vitamin E concentration" ; rdfs:subClassOf obo:HP_0100508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042360 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100515 obo:IAO_0000115 "Increased frequency of urination." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:34:28Z" ; oboInOwl:hasBroadSynonym "Constant urination" ; oboInOwl:hasDbXref "SNOMEDCT_US:162116003", "SNOMEDCT_US:300471006", "UMLS:C0042023" ; oboInOwl:hasExactSynonym "Frequent urination" ; oboInOwl:id "HP:0100515" ; a owl:Class ; rdfs:label "Pollakisuria" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0100516 obo:IAO_0000115 "The presence of a neoplasm of the ureter." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:35:11Z" ; oboInOwl:hasDbXref "MSH:D014516", "NCIT:C3262", "SNOMEDCT_US:126882009", "SNOMEDCT_US:363458004", "UMLS:C0041955", "UMLS:C0153619" ; oboInOwl:hasRelatedSynonym "Neoplasia of the ureters", "ureter, cancer of" ; oboInOwl:id "HP:0100516" ; a owl:Class ; rdfs:label "Neoplasm of the ureter" ; rdfs:subClassOf obo:HP_0000069, obo:HP_0010786 . obo:HP_0100517 obo:IAO_0000115 "The presence of a neoplasm of the urethra." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:36:17Z" ; oboInOwl:hasDbXref "MSH:D014523", "NCIT:C2974", "SNOMEDCT_US:126883004", "UMLS:C0041971" ; oboInOwl:hasRelatedSynonym "Neoplasia of the urethra" ; oboInOwl:id "HP:0100517" ; a owl:Class ; rdfs:label "Neoplasm of the urethra" ; rdfs:subClassOf obo:HP_0000795, obo:HP_0010786 . obo:HP_0100518 obo:IAO_0000115 "Painful or difficult urination." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:40:36Z" ; oboInOwl:hasDbXref "MSH:D053159", "SNOMEDCT_US:49650001", "UMLS:C0013428" ; oboInOwl:hasExactSynonym "Painful or difficult urination" ; oboInOwl:hasRelatedSynonym "Dull burning sensation with urination" ; oboInOwl:id "HP:0100518" ; a owl:Class ; rdfs:label "Dysuria" ; rdfs:subClassOf obo:HP_0000009 . obo:HP_0100519 obo:IAO_0000115 "Absence of urine, clinically classified as below 50ml/day." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:41:00Z" ; oboInOwl:hasDbXref "MSH:D001002", "SNOMEDCT_US:2472002", "UMLS:C0003460" ; oboInOwl:hasExactSynonym "Absent urine output" ; oboInOwl:id "HP:0100519" ; a owl:Class ; rdfs:label "Anuria" ; rdfs:subClassOf obo:HP_0011037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0060073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100520 obo:IAO_0000115 "Low output of urine, clinically classified as an output below 300-500ml/day." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T10:42:40Z" ; oboInOwl:hasDbXref "MSH:D009846", "SNOMEDCT_US:718403007", "SNOMEDCT_US:83128009", "UMLS:C0028961" ; oboInOwl:id "HP:0100520" ; a owl:Class ; rdfs:comment "The decreased output of urine may be a sign of dehydration, renal failure, hypovolemic shock, multiple organ dysfunction syndrome, or urinary obstruction/urinary retention." ; rdfs:label "Oliguria" ; rdfs:subClassOf obo:HP_0011037 . obo:HP_0100521 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the thymus." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:02:03Z" ; oboInOwl:hasDbXref "MSH:D013953", "NCIT:C3262", "SNOMEDCT_US:127231009", "UMLS:C3714644" ; oboInOwl:id "HP:0100521" ; a owl:Class ; rdfs:label "Neoplasm of the thymus" ; rdfs:subClassOf obo:HP_0000777, obo:HP_0011793 . obo:HP_0100522 obo:IAO_0000115 "A tumor originating from the epithelial cells of the thymus." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:02:22Z" ; oboInOwl:hasDbXref "MSH:D013945", "NCIT:C3411", "SNOMEDCT_US:128856005", "SNOMEDCT_US:444231005", "UMLS:C0040100" ; oboInOwl:id "HP:0100522" ; a owl:Class ; rdfs:comment "Malignant lymphomas that involve the thymus, such as lymphoblastic lymphoma and Hodgkin lymphoma (erroneously termed \"granulomatous thymoma\" in the past), should not be regarded as thymomas. Thymoma is an uncommon tumor, best known for its association with the neuromuscular disorder myasthenia gravis. Thymoma is found in 15% of patients with myasthenia gravis." ; rdfs:label "Thymoma" ; rdfs:subClassOf obo:HP_0100521 . obo:HP_0100523 obo:IAO_0000115 "The presence of an abscess of the liver." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:13:14Z" ; oboInOwl:hasAlternativeId "HP:0001400" ; oboInOwl:hasDbXref "MSH:D008100", "SNOMEDCT_US:27916005", "UMLS:C0023885" ; oboInOwl:hasExactSynonym "Hepatic abscess", "Liver abscess" ; oboInOwl:id "HP:0100523" ; a owl:Class ; rdfs:label "Liver abscess" ; rdfs:subClassOf obo:HP_0025615, obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100524 obo:IAO_0000115 "Congenital duplication of all or part of a limb." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:32:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:34488005", "UMLS:C0265551" ; oboInOwl:hasExactSynonym "Dimelia", "Limb duplication" ; oboInOwl:id "HP:0100524" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Limb duplication" ; rdfs:subClassOf obo:HP_0002813 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100525 obo:IAO_0000115 "Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:40:58Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:398320008", "SNOMEDCT_US:50986000", "UMLS:C0345344" ; oboInOwl:id "HP:0100525" ; a owl:Class ; rdfs:label "Urachus fistula" ; rdfs:subClassOf obo:HP_0010478 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002068 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100526 obo:IAO_0000115 "Tumor of the lung." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:47:12Z" ; oboInOwl:hasBroadSynonym "Lung cancer" ; oboInOwl:hasDbXref "MSH:D008175", "NCIT:C3262", "SNOMEDCT_US:126713003", "UMLS:C0024121" ; oboInOwl:hasExactSynonym "Lung tumor", "Lung tumour" ; oboInOwl:id "HP:0100526" ; a owl:Class ; rdfs:label "Neoplasm of the lung" ; rdfs:subClassOf obo:HP_0002088, obo:HP_0100606 . obo:HP_0100527 dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:47:33Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4022033" ; oboInOwl:id "HP:0100527" ; a owl:Class ; rdfs:label "Neoplasia of the pleura" ; rdfs:subClassOf obo:HP_0002103, obo:HP_0100606 . obo:HP_0100528 obo:IAO_0000115 "A rare cancer originating in the lung or pleural cavity that occurs most often in infants and young children but also has been reported in adults. Pleuropulmonary blastoma is regarded as malignant." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:48:57Z" ; oboInOwl:hasDbXref "MSH:C537516", "NCIT:C3732", "SNOMEDCT_US:128763002", "SNOMEDCT_US:707670009", "UMLS:C1266144" ; oboInOwl:id "HP:0100528" ; a owl:Class ; rdfs:label "Pleuropulmonary blastoma" ; rdfs:subClassOf obo:HP_0100527, obo:HP_0100552 . obo:HP_0100529 obo:IAO_0000115 "An abnormality of phosphate homeostasis or concentration in the body." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T11:58:32Z" ; oboInOwl:hasDbXref "UMLS:C4022032" ; oboInOwl:hasExactSynonym "Abnormality of phosphate homeostasis" ; oboInOwl:id "HP:0100529" ; a owl:Class ; rdfs:label "Abnormal blood phosphate concentration" ; rdfs:subClassOf obo:HP_0003111 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0055062 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100530 obo:IAO_0000115 "Any deviation from the normal concentration in the blood circulation of a hormone that is involved in the regulation of phosphate and calcium." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T12:00:26Z" ; oboInOwl:hasDbXref "UMLS:C4022031" ; oboInOwl:hasExactSynonym "Abnormal Ca-PHOS regulating hormone level", "Abnormal Ca2+ PO4 regulating hormone level" ; oboInOwl:id "HP:0100530" ; a owl:Class ; rdfs:label "Abnormal circulating calcium-phosphate regulating hormone concentration" ; rdfs:subClassOf obo:HP_0003117, obo:HP_0033331 . obo:HP_0100531 obo:IAO_0000115 "The appearance of abnormal valgus deformity in one knee in association with varus deformity in the other." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T12:43:09Z" ; oboInOwl:hasDbXref "UMLS:C4022030" ; oboInOwl:hasExactSynonym "Wind-swept deformity of the knees" ; oboInOwl:id "HP:0100531" ; a owl:Class ; rdfs:label "Wind-swept deformity of the knees" ; rdfs:subClassOf obo:HP_0002857, obo:HP_0002970 . obo:HP_0100532 obo:IAO_0000115 "Inflammation of the sclera." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T03:50:04Z" ; oboInOwl:hasBroadSynonym "Inflammation of the outer white part of the eye" ; oboInOwl:hasDbXref "MSH:D015423", "SNOMEDCT_US:78370002", "UMLS:C0036416" ; oboInOwl:id "HP:0100532" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Scleritis may be accompanied by blurred vision, eye pain, redness of the (normally white) sclera, photophobia, and tearing." ; rdfs:label "Scleritis" ; rdfs:subClassOf obo:HP_0000591, obo:HP_0100533 . obo:HP_0100533 obo:IAO_0000115 "Inflammation of the eye, parts of the eye or the periorbital region." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T03:53:42Z" ; oboInOwl:hasAlternativeId "HP:0007891" ; oboInOwl:hasDbXref "UMLS:C4020969" ; oboInOwl:hasExactSynonym "Inflammatory abnormality of the eye", "Ocular inflammation" ; oboInOwl:id "HP:0100533" ; a owl:Class ; rdfs:label "Inflammatory abnormality of the eye" ; rdfs:subClassOf obo:HP_0012373, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0010230 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100534 obo:IAO_0000115 "Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T05:48:22Z" ; oboInOwl:hasDbXref "MSH:D015423", "SNOMEDCT_US:815008", "UMLS:C0014583" ; oboInOwl:hasExactSynonym "Inflammation of the thin layer on top of the white part of eye" ; oboInOwl:id "HP:0100534" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In contrast to conjunctivitis, with episcleritis the inflammation is generally limited to isolated parts of the sclera and is not diffuse.One can observe dilated episcleral blood vessels between regions of white sclera." ; rdfs:label "Episcleritis" ; rdfs:subClassOf obo:HP_0000591, obo:HP_0100533 . obo:HP_0100535 dcterms:creator ; oboInOwl:creation_date "2010-12-20T05:53:38Z" ; oboInOwl:hasDbXref "UMLS:C4022029" ; oboInOwl:id "HP:0100535" ; a owl:Class ; rdfs:label "Tibiofibular diastasis" ; rdfs:subClassOf obo:HP_0002991, obo:HP_0002992 . obo:HP_0100536 obo:IAO_0000115 "An abnormality of fascia." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T05:58:56Z" ; oboInOwl:hasDbXref "UMLS:C4022028" ; oboInOwl:id "HP:0100536" ; a owl:Class ; rdfs:label "Abnormality of the fascia" ; rdfs:subClassOf obo:HP_0003549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008982 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100537 obo:IAO_0000115 "Inflammation of fascia, the tissue under the skin and over the muscle." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T05:59:18Z" ; oboInOwl:hasDbXref "MSH:D005208", "SNOMEDCT_US:36948007", "UMLS:C0015645" ; oboInOwl:hasExactSynonym "Inflammation of the fascia" ; oboInOwl:id "HP:0100537" ; a owl:Class ; rdfs:label "Fasciitis" ; rdfs:subClassOf obo:HP_0012649, obo:HP_0100536 ; owl:equivalentClass _:genid101287 . obo:HP_0100538 obo:IAO_0000115 "An anomaly of the supraorbital portion of the frontal bones." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:05:56Z" ; oboInOwl:hasDbXref "UMLS:C4022027" ; oboInOwl:hasExactSynonym "Abnormality of the brow of the face" ; oboInOwl:hasNarrowSynonym "Deformity of the supraorbital margins", "Deformity of the supraorbital ridges", "Malformation of the supraorbital margins", "Malformation of the supraorbital ridges" ; oboInOwl:id "HP:0100538" ; a owl:Class ; rdfs:label "Abnormality of the supraorbital ridges" ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0100539 obo:IAO_0000115 "Edema affecting the region situated around the orbit of the eye." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:09:04Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:109245003", "SNOMEDCT_US:267041004", "SNOMEDCT_US:49563000", "UMLS:C0149754", "UMLS:C0151205", "UMLS:C0424810" ; oboInOwl:hasExactSynonym "Periorbital cellulitis", "Periorbital oedema" ; oboInOwl:id "HP:0100539" ; a owl:Class ; rdfs:label "Periorbital edema" ; rdfs:subClassOf obo:HP_0000282, obo:HP_0000606 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004090 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100540 obo:IAO_0000115 "Edema in the region of the eyelids." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:09:32Z" ; oboInOwl:hasAlternativeId "HP:0000626" ; oboInOwl:hasDbXref "SNOMEDCT_US:89091004", "UMLS:C0162285" ; oboInOwl:hasExactSynonym "Edema of the eyelids", "Eyelid edema", "Eyelid oedema", "Fullness of eyelids", "Oedema of the eyelids", "Palpebral oedema", "Puffy eyelids", "Puffy lids", "Swelling of eyelids" ; oboInOwl:id "HP:0100540" ; a owl:Class ; rdfs:label "Palpebral edema" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0100539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100541 obo:IAO_0000115 "A hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:16:40Z" ; oboInOwl:hasDbXref "MEDDRA:10016434", "MSH:D006550", "SNOMEDCT_US:50063009", "UMLS:C0019288" ; oboInOwl:hasExactSynonym "Crural hernia" ; oboInOwl:id "HP:0100541" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Femoral hernias are a relatively uncommon type, accounting for only 3% of all hernias. Femoral hernia appears as a bulge in the upper thigh." ; rdfs:label "Femoral hernia" ; rdfs:subClassOf obo:HP_0004299 . obo:HP_0100542 obo:IAO_0000115 "An abnormal site of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:43:50Z" ; oboInOwl:hasDbXref "UMLS:C4020968" ; oboInOwl:hasExactSynonym "Abnormal localisation of kidneys" ; oboInOwl:id "HP:0100542" ; a owl:Class ; rdfs:label "Abnormal localization of kidney" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100543 obo:IAO_0000115 "Abnormal cognition with deficits in thinking, reasoning, or remembering." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T06:50:32Z" ; oboInOwl:hasAlternativeId "HP:0002128", "HP:0002129", "HP:0002302", "HP:0002337", "HP:0002441", "HP:0006972", "HP:0006998", "HP:0007211" ; oboInOwl:hasDbXref "MSH:D060825", "SNOMEDCT_US:386806002", "UMLS:C0338656", "UMLS:C0683322" ; oboInOwl:hasExactSynonym "Abnormality of cognition", "Cognitive abnormality", "Cognitive defects", "Cognitive deficits", "Cognitive impairment", "Intellectual impairment" ; oboInOwl:id "HP:0100543" ; a owl:Class ; rdfs:comment "An individual with cognitive impairment may have trouble remembering, learning new things, concentrating, or making decisions." ; rdfs:label "Cognitive impairment" ; rdfs:subClassOf obo:HP_0011446 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:GO_0050890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100544 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the heart." ; dcterms:creator ; oboInOwl:creation_date "2010-12-20T07:00:31Z" ; oboInOwl:hasDbXref "MSH:D006338", "NCIT:C3262", "SNOMEDCT_US:387842002", "UMLS:C0018809" ; oboInOwl:hasExactSynonym "Cardiac neoplasm", "Heart tumor", "Heart tumour" ; oboInOwl:hasRelatedSynonym "Cardiac neoplasia" ; oboInOwl:id "HP:0100544" ; a owl:Class ; rdfs:label "Neoplasm of the heart" ; rdfs:subClassOf obo:HP_0001627, obo:HP_0011793 . obo:HP_0100545 obo:IAO_0000115 "Narrowing or constriction of the inner surface (lumen) of an artery." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T01:30:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:68109007", "UMLS:C0038449" ; oboInOwl:hasExactSynonym "Narrowing of an artery" ; oboInOwl:id "HP:0100545" ; a owl:Class ; rdfs:label "Arterial stenosis" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100546 obo:IAO_0000115 "Narrowing of the carotid arteries." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T01:31:46Z" ; oboInOwl:hasDbXref "MSH:D016893", "SNOMEDCT_US:64586002", "UMLS:C0007282" ; oboInOwl:hasExactSynonym "Carotid stenosis", "Narrowing of carotid artery" ; oboInOwl:id "HP:0100546" ; a owl:Class ; rdfs:comment "Carotid artery stenosis is usually caused by caused by atherosclerosis." ; rdfs:label "Carotid artery stenosis" ; rdfs:subClassOf obo:HP_0005344, obo:HP_0100545 . obo:HP_0100547 obo:IAO_0000115 "An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T02:12:53Z" ; oboInOwl:hasDbXref "UMLS:C4020967" ; oboInOwl:hasExactSynonym "Abnormal shape of forebrain", "Abnormality of forebrain morphology", "Abnormality of the forebrain" ; oboInOwl:id "HP:0100547" ; a owl:Class ; rdfs:label "Abnormal forebrain morphology" ; rdfs:subClassOf obo:HP_0012443 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100548 obo:IAO_0000115 "Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T02:20:01Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:110407002", "UMLS:C0015338" ; oboInOwl:id "HP:0100548" ; a owl:Class ; rdfs:label "Exstrophy" ; rdfs:subClassOf obo:HP_0004298 . obo:HP_0100550 obo:IAO_0000115 "Breakage (tear) of a tendon." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T02:58:13Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:415749005", "UMLS:C0151937" ; oboInOwl:hasExactSynonym "Rupture of tendons", "Ruptured tendon", "Tendon rupture", "Tendon/muscle rupture" ; oboInOwl:id "HP:0100550" ; a owl:Class ; rdfs:comment "Tendon rupture is usually painful,and accompanied by swelling, inability to move, and bunching up of the muscle normally attached to the tendon." ; rdfs:label "Tendon rupture" ; rdfs:subClassOf obo:HP_0100261 . obo:HP_0100551 obo:IAO_0000115 "A neoplasm of the trachea." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T03:44:37Z" ; oboInOwl:hasAlternativeId "HP:0012291" ; oboInOwl:hasDbXref "MSH:D014134", "NCIT:C3262", "SNOMEDCT_US:126703006", "UMLS:C0040582" ; oboInOwl:hasExactSynonym "Tracheal neoplasm" ; oboInOwl:id "HP:0100551" ; a owl:Class ; rdfs:label "Neoplasm of the trachea" ; rdfs:subClassOf obo:HP_0002778, obo:HP_0100552 . obo:HP_0100552 dcterms:creator ; oboInOwl:creation_date "2010-12-21T03:46:30Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4022026" ; oboInOwl:id "HP:0100552" ; a owl:Class ; rdfs:label "Neoplasm of the tracheobronchial system" ; rdfs:subClassOf obo:HP_0005607, obo:HP_0100526 . obo:HP_0100553 obo:IAO_0000115 "Overgrowth of only one leg." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T03:58:40Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:205369009", "UMLS:C0431928" ; oboInOwl:hasExactSynonym "Overgrowth of one leg" ; oboInOwl:id "HP:0100553" ; a owl:Class ; rdfs:label "Hemihypertrophy of lower limb" ; rdfs:subClassOf obo:HP_0001528, obo:HP_0010496, obo:HP_0100559 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0100554 obo:IAO_0000115 "Overgrowth of only one arm." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T03:58:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253920006", "UMLS:C0431810" ; oboInOwl:hasExactSynonym "Overgrowth of one arm" ; oboInOwl:id "HP:0100554" ; a owl:Class ; rdfs:label "Hemihypertrophy of upper limb" ; rdfs:subClassOf obo:HP_0001528, obo:HP_0010484, obo:HP_0100560 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0100555 obo:IAO_0000115 "A growth pattern that displays an abnormal difference between the left and the right side." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:00:12Z" ; oboInOwl:hasDbXref "UMLS:C4022025" ; oboInOwl:hasExactSynonym "Uneven or disproportionate growth of one body part compared to another" ; oboInOwl:id "HP:0100555" ; a owl:Class ; rdfs:label "Asymmetric growth" ; rdfs:subClassOf obo:HP_0001507 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0040007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100556 obo:IAO_0000115 "Undergrowth of the limbs that affects only one side." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:01:10Z" ; oboInOwl:hasAlternativeId "HP:0005091", "HP:0200051" ; oboInOwl:hasDbXref "SNOMEDCT_US:34087007", "UMLS:C0333662" ; oboInOwl:hasExactSynonym "Asymmetric limb shortening", "Hemiatrophy of the body" ; oboInOwl:id "HP:0100556" ; a owl:Class ; rdfs:label "Hemiatrophy" ; rdfs:subClassOf obo:HP_0009826, obo:HP_0100555 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0100557 obo:IAO_0000115 "Unilateral atrophy (reduction in size) of a leg." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:01:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:709411004", "UMLS:C0431934" ; oboInOwl:hasExactSynonym "Asymmetric lower limb shortening" ; oboInOwl:id "HP:0100557" ; a owl:Class ; rdfs:label "Hemiatrophy of lower limb" ; rdfs:subClassOf obo:HP_0100556, obo:HP_0100559 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0100558 obo:IAO_0000115 "Unilateral atrophy (reduction in size) of an arm." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:01:48Z" ; oboInOwl:hasAlternativeId "HP:0200052" ; oboInOwl:hasDbXref "SNOMEDCT_US:253921005", "UMLS:C0431814" ; oboInOwl:hasExactSynonym "Asymmetric upper limb shortening", "Hemihypotrophy of upper limb" ; oboInOwl:id "HP:0100558" ; a owl:Class ; rdfs:label "Hemiatrophy of upper limb" ; rdfs:subClassOf obo:HP_0100556, obo:HP_0100560 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0100559 obo:IAO_0000115 "A difference in length or diameter between the left and right leg." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:04:27Z" ; oboInOwl:hasDbXref "MSH:D007870", "SNOMEDCT_US:45939007", "UMLS:C0023221" ; oboInOwl:hasExactSynonym "Left and right leg differ in length or width" ; oboInOwl:hasRelatedSynonym "Leg length discrepancy" ; oboInOwl:id "HP:0100559" ; a owl:Class ; rdfs:label "Lower limb asymmetry" ; rdfs:subClassOf obo:HP_0002814, obo:HP_0100555 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010709 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100560 obo:IAO_0000115 "Difference in length or size between the right and left arm." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:04:56Z" ; oboInOwl:hasDbXref "UMLS:C4022024" ; oboInOwl:hasExactSynonym "Unequal size of arms" ; oboInOwl:id "HP:0100560" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Upper limb asymmetry" ; rdfs:subClassOf obo:HP_0002817, obo:HP_0100555 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010708 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100561 dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:34:03Z" ; oboInOwl:hasDbXref "UMLS:C0241224" ; oboInOwl:id "HP:0100561" ; a owl:Class ; rdfs:label "Spinal cord lesion" ; rdfs:subClassOf obo:HP_0002143 . obo:HP_0100562 obo:IAO_0000115 "Duplication of the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:35:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:360527003", "UMLS:C1260890" ; oboInOwl:hasExactSynonym "Duplication of spinal cord" ; oboInOwl:id "HP:0100562" ; a owl:Class ; rdfs:label "Diplomyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0100563 obo:IAO_0000115 "Coexistence of two hemicords, at variable levels, causing splaying of the posterior vertebral elements. Results in neurological deficits in lower limb or perineum." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:35:22Z" ; oboInOwl:hasDbXref "UMLS:C4022023" ; oboInOwl:id "HP:0100563" ; a owl:Class ; rdfs:label "Diastomatomyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0100564 obo:IAO_0000115 "Triplication of the spinal cord - extremely rare." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:35:22Z" ; oboInOwl:hasDbXref "UMLS:C4022022" ; oboInOwl:hasExactSynonym "Triplication of spinal cord" ; oboInOwl:id "HP:0100564" ; a owl:Class ; rdfs:label "Triplomyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0100565 obo:IAO_0000115 "Dilation of central canal from incomplete fusion of the posterior columns or persistence of the primitive large canal of the embryo." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:35:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:11197005", "SNOMEDCT_US:74740003", "UMLS:C0152444" ; oboInOwl:id "HP:0100565" ; a owl:Class ; rdfs:label "Hydromyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0100566 obo:IAO_0000115 "Congenital absence of the spinal cord." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:41:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:78784005", "UMLS:C0266510" ; oboInOwl:hasExactSynonym "Absent spinal cord" ; oboInOwl:id "HP:0100566" ; a owl:Class ; rdfs:label "Amyelia" ; rdfs:subClassOf obo:HP_0100561 . obo:HP_0100568 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the endocrine system." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:55:15Z" ; oboInOwl:hasDbXref "MSH:D004701", "NCIT:C3262", "SNOMEDCT_US:387922007", "SNOMEDCT_US:387927001", "UMLS:C0014132" ; oboInOwl:hasExactSynonym "Endocrine neoplasia" ; oboInOwl:id "HP:0100568" ; a owl:Class ; rdfs:label "Neoplasm of the endocrine system" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0011793 . obo:HP_0100569 obo:IAO_0000115 "An abnormality of the formation and mineralization of one or more vertebrae." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:50:43Z" ; oboInOwl:hasDbXref "UMLS:C4020966" ; oboInOwl:hasExactSynonym "Abnormal bone maturation of vertebra", "Abnormal vertebral ossification", "Abnormality of ossification/mineralisation of vertebrae" ; oboInOwl:id "HP:0100569" ; a owl:Class ; rdfs:label "Abnormally ossified vertebrae" ; rdfs:subClassOf obo:HP_0003336, obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100570 obo:IAO_0000115 "A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T04:57:15Z" ; oboInOwl:hasDbXref "MSH:D002276", "SNOMEDCT_US:189607006", "SNOMEDCT_US:443492008", "UMLS:C0007095" ; oboInOwl:hasExactSynonym "Carcinoid", "Carcinoid tumour" ; oboInOwl:hasRelatedSynonym "Carcinoid tumors", "Carcinoid tumours" ; oboInOwl:id "HP:0100570" ; a owl:Class ; rdfs:label "Carcinoid tumor" ; rdfs:subClassOf obo:HP_0100634 . obo:HP_0100571 obo:IAO_0000115 "A cardiac diverticulum is a rare congenital malformation which is either fibrous or muscular." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T05:11:26Z" ; oboInOwl:hasDbXref "UMLS:C4020965" ; oboInOwl:hasExactSynonym "Ventricular diverticulum" ; oboInOwl:id "HP:0100571" ; a owl:Class ; rdfs:label "Cardiac diverticulum" ; rdfs:subClassOf obo:HP_0001713 . obo:HP_0100572 obo:IAO_0000115 "A fibrous cardiac diverticulum refers to an aneurysm and usually appears as an isolated congenital anomaly." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T05:14:00Z" ; oboInOwl:hasDbXref "UMLS:C4020964" ; oboInOwl:hasExactSynonym "Congenital ventricular aneurysm" ; oboInOwl:id "HP:0100572" ; a owl:Class ; rdfs:label "Fibrous cardiac diverticulum" ; rdfs:subClassOf obo:HP_0006698, obo:HP_0100571 . obo:HP_0100573 dcterms:creator ; oboInOwl:creation_date "2010-12-21T05:14:00Z" ; oboInOwl:hasDbXref "UMLS:C4022021" ; oboInOwl:id "HP:0100573" ; a owl:Class ; rdfs:label "Muscular cardiac diverticulum" ; rdfs:subClassOf obo:HP_0100571 . obo:HP_0100574 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the biliary system." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T05:18:27Z" ; oboInOwl:hasAlternativeId "HP:0030152" ; oboInOwl:hasDbXref "MSH:D001661", "NCIT:C3262", "SNOMEDCT_US:126853008", "UMLS:C0005426", "UMLS:C4020709" ; oboInOwl:hasRelatedSynonym "Neoplasia of the biliary tract" ; oboInOwl:id "HP:0100574" ; a owl:Class ; rdfs:label "Biliary tract neoplasm" ; rdfs:subClassOf obo:HP_0007378, obo:HP_0012440 . obo:HP_0100575 obo:IAO_0000115 "The presence of a neoplasm of the gallbladder." ; dcterms:creator ; oboInOwl:creation_date "2010-12-21T05:18:44Z" ; oboInOwl:hasDbXref "MSH:D005706", "NCIT:C3262", "SNOMEDCT_US:126854002", "UMLS:C0016978", "UMLS:C4020708" ; oboInOwl:hasRelatedSynonym "Neoplasia of the gallbladder" ; oboInOwl:id "HP:0100575" ; a owl:Class ; rdfs:label "Neoplasm of the gallbladder" ; rdfs:subClassOf obo:HP_0012437, obo:HP_0100574 . obo:HP_0100576 obo:IAO_0000115 "A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T12:42:59Z" ; oboInOwl:hasDbXref "MSH:D020757", "SNOMEDCT_US:88032003", "UMLS:C0149793" ; oboInOwl:id "HP:0100576" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Amaurosis fugax" ; rdfs:subClassOf obo:HP_0000504 . obo:HP_0100577 obo:IAO_0000115 "Inflammation of the urinary bladder." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T12:49:16Z" ; oboInOwl:hasDbXref "MSH:D003556", "SNOMEDCT_US:38822007", "UMLS:C0010692" ; oboInOwl:hasExactSynonym "Cystitis of the urinary bladder", "Urinary bladder inflammation" ; oboInOwl:id "HP:0100577" ; a owl:Class ; rdfs:label "Urinary bladder inflammation" ; rdfs:subClassOf obo:HP_0012649, obo:HP_0025487 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100578 obo:IAO_0000115 "Localized loss of fat tissue." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T12:55:33Z" ; oboInOwl:hasDbXref "MEDDRA:10024604", "SNOMEDCT_US:248315005", "UMLS:C1280433" ; oboInOwl:hasExactSynonym "Atrophy of fat", "Loss of fat tissue in localised area", "Loss of fat tissue in localized area" ; oboInOwl:id "HP:0100578" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This may occur as a result of subcutanous injections of insulin in the treatment of diabetes, from the use of human growth hormone or from subcutanous injections of Copaxone used for the treatment of multiple sclerosis. In the latter case, an injection may produce a small dent at the injection site. Lipoatrophy is also an adverse drug reaction that is associated with some antiretroviral drugs." ; rdfs:label "Lipoatrophy" ; rdfs:subClassOf obo:HP_0009125 . obo:HP_0100579 obo:IAO_0000115 "Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T01:04:18Z" ; oboInOwl:hasDbXref "UMLS:C4022020" ; oboInOwl:id "HP:0100579" ; a owl:Class ; rdfs:label "Mucosal telangiectasiae" ; rdfs:subClassOf obo:HP_0001009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000344 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100580 obo:IAO_0000115 "An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T01:33:00Z" ; oboInOwl:hasDbXref "MSH:D001471", "SNOMEDCT_US:302914006", "UMLS:C0004763" ; oboInOwl:hasExactSynonym "Barret syndrome", "Barrett oesophagus", "Barrett's esophagus", "Barrett's oesophagus", "Endobrachyesophagus" ; oboInOwl:id "HP:0100580" ; a owl:Class ; rdfs:comment "The medical significance of Barrett esophagus is its strong association with esophageal adenocarcinoma, a particularly lethal cancer." ; rdfs:label "Barrett esophagus" ; rdfs:subClassOf obo:HP_0100751 . obo:HP_0100581 obo:IAO_0000115 "An abnormal enlargement of the renal calices, the system of ducts of the kidney that collect urine." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T02:44:04Z" ; oboInOwl:hasDbXref "UMLS:C4022019" ; oboInOwl:hasExactSynonym "Caliceal dilatation", "Caliectasis" ; oboInOwl:hasRelatedSynonym "Megacalicosis" ; oboInOwl:id "HP:0100581" ; a owl:Class ; rdfs:label "Dilatation of renal calices" ; rdfs:subClassOf obo:HP_0011130 . obo:HP_0100582 obo:IAO_0000115 "Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T02:47:15Z" ; oboInOwl:hasAlternativeId "HP:0000462" ; oboInOwl:hasDbXref "MSH:D009298", "SNOMEDCT_US:52756005", "UMLS:C0027430" ; oboInOwl:hasExactSynonym "Nasal polyps", "Polyposis nasi", "Polyps of nose" ; oboInOwl:id "HP:0100582" ; a owl:Class ; rdfs:comment "Nasal polyps (NP) are benign lesions arising from the mucosa of the nasal sinuses (commonly at the outflow tract of one or more of the sinuses) or from the mucosa of the nasal cavity. The main presenting symptom of NP is nasal obstruction which is constant but can vary depending on the site and size of the polyps. Sufferers will also frequently complain of watery rhinorrhea and postnasal drip. Anosmia or hyposmia with an ensuing alteration in taste are also characteristic symptoms of NP." ; rdfs:label "Nasal polyposis" ; rdfs:subClassOf obo:HP_0000433 . obo:HP_0100583 obo:IAO_0000115 "A rupture of the cornea through which a portion of the iris protrudes." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T02:52:19Z" ; oboInOwl:hasAlternativeId "HP:0100793" ; oboInOwl:hasDbXref "MSH:D057112", "SNOMEDCT_US:74895004", "UMLS:C0339293", "UMLS:C0948060" ; oboInOwl:hasExactSynonym "Iridocele" ; oboInOwl:id "HP:0100583" ; a owl:Class ; rdfs:label "Corneal perforation" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002112 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100584 obo:IAO_0000115 "An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T02:57:48Z" ; oboInOwl:hasDbXref "MSH:D004696", "SNOMEDCT_US:56819008", "UMLS:C0014118" ; oboInOwl:id "HP:0100584" ; a owl:Class ; rdfs:label "Endocarditis" ; rdfs:subClassOf obo:HP_0004306, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002165 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100585 obo:IAO_0000115 "Presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T03:06:35Z" ; oboInOwl:hasAlternativeId "HP:0007561" ; oboInOwl:hasDbXref "UMLS:C4022018" ; oboInOwl:hasExactSynonym "Teleangiectasia of the skin" ; oboInOwl:id "HP:0100585" ; a owl:Class ; rdfs:label "Telangiectasia of the skin" ; rdfs:subClassOf obo:HP_0001009 . obo:HP_0100586 obo:IAO_0000115 "Patients who routinely have greater than 20 leukocytes per microliter, but have abacterial urine, are said to have sterile pyuria." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T03:09:12Z" ; oboInOwl:hasDbXref "UMLS:C4022017" ; oboInOwl:hasExactSynonym "Aseptic leukocyturia" ; oboInOwl:id "HP:0100586" ; a owl:Class ; rdfs:label "Sterile pyuria" ; rdfs:subClassOf obo:HP_0012085 . obo:HP_0100587 obo:IAO_0000115 "An abnormality of the retractable fold of skin that covers the tip of the penis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T03:13:07Z" ; oboInOwl:hasDbXref "UMLS:C4022016" ; oboInOwl:hasExactSynonym "Abnormality of the preputium" ; oboInOwl:id "HP:0100587" ; a owl:Class ; rdfs:label "Abnormal preputium morphology" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100588 obo:IAO_0000115 "The foreskin becomes trapped behind the glans penis, and cannot be pulled back to its normal flaccid position covering the glans penis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T03:13:30Z" ; oboInOwl:hasDbXref "MSH:D010263", "SNOMEDCT_US:13758004", "UMLS:C0030483" ; oboInOwl:id "HP:0100588" ; a owl:Class ; rdfs:label "Paraphimosis" ; rdfs:subClassOf obo:HP_0100587 . obo:HP_0100589 obo:IAO_0000115 "The presence of a fistula affecting the genitourinary system." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:09:23Z" ; oboInOwl:hasDbXref "UMLS:C0853877" ; oboInOwl:id "HP:0100589" ; a owl:Class ; rdfs:label "Urogenital fistula" ; rdfs:subClassOf obo:HP_0000119 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004122 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100590 obo:IAO_0000115 "The presence of a fistula affecting the rectum." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:11:26Z" ; oboInOwl:hasDbXref "MSH:D012003", "SNOMEDCT_US:80736008", "UMLS:C0034884" ; oboInOwl:id "HP:0100590" ; a owl:Class ; rdfs:label "Rectal fistula" ; rdfs:subClassOf obo:HP_0002034, obo:HP_0100589, obo:HP_0100819 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100592 obo:IAO_0000115 "The presence of an abscess of the peritoneum." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:30:53Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:73962000", "UMLS:C0267756" ; oboInOwl:id "HP:0100592" ; a owl:Class ; rdfs:label "Peritoneal abscess" ; rdfs:subClassOf obo:HP_0002585, obo:HP_0025615 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_608 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100593 obo:IAO_0000115 "The presence of calcium deposition in cartilage." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:35:28Z" ; oboInOwl:hasDbXref "UMLS:C4022015" ; oboInOwl:id "HP:0100593" ; a owl:Class ; rdfs:label "Calcification of cartilage" ; rdfs:subClassOf obo:HP_0002763, obo:HP_0010766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100594 obo:IAO_0000115 "Thin (2-3mm) membranes of normal esophageal tissue consisting of mucosa and submucosa that can be congenital or acquired. Congenital webs commonly appear in the middle and inferior third of the esophagus, and they are more likely to be circumferential with a central or eccentric orifice. Acquired webs are much more common than congenital webs and typically appear in the cervical area (postcricoid). Clinical symptoms of this condition are selective (solid more than liquids) dysphagia, thoracic pain, nasopharyngeal reflux, aspiration, perforation and food impaction (the last two are very rare)." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:51:07Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19216006", "SNOMEDCT_US:22395006", "UMLS:C0267080" ; oboInOwl:id "HP:0100594" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Esophageal web" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0100595 obo:IAO_0000115 "An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T04:55:11Z" ; oboInOwl:hasDbXref "MSH:C537968", "SNOMEDCT_US:13534001", "UMLS:C0264162" ; oboInOwl:id "HP:0100595" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Camptocormia" ; rdfs:subClassOf obo:HP_0010674 . obo:HP_0100596 obo:IAO_0000115 "The nostrils (the paired channels of the nose) are not present." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:07:16Z" ; oboInOwl:hasAlternativeId "HP:0100597" ; oboInOwl:hasDbXref "UMLS:C4020707", "UMLS:C4020963" ; oboInOwl:hasExactSynonym "Abouphalia", "Aplasia of the nares", "Missing nostrils" ; oboInOwl:hasRelatedSynonym "Aplasia/Hypoplasia of the nares" ; oboInOwl:id "HP:0100596" ; a owl:Class ; rdfs:label "Absent nares" ; rdfs:subClassOf obo:HP_0005288 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005928 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100598 obo:IAO_0000115 "Fluid accumulation in the lungs." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:10:09Z" ; oboInOwl:hasDbXref "MSH:D011654", "SNOMEDCT_US:19242006", "UMLS:C0034063" ; oboInOwl:hasExactSynonym "Excess fluid in lungs", "Lung edema", "Lung oedema", "Pulmonary oedema", "Wet lung" ; oboInOwl:id "HP:0100598" ; a owl:Class ; rdfs:label "Pulmonary edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0002088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100599 obo:IAO_0000115 "Two penile structures, separated from the tip to the base of the shaft." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:17:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253851000", "UMLS:C0345322" ; oboInOwl:hasExactSynonym "Diphallia", "Penile duplication" ; oboInOwl:id "HP:0100599" ; a owl:Class ; rdfs:comment "In individuals with complete duplication often one will find Hypospadias, Epispadias, Bladder exstrophy, or Bifid scrotum, which should be coded separately, as well as urinary tract duplications, renal anomalies, and gastrointestinal duplications. The terms indicate the presence of (part of) two penises, but do not indicate whether they are caused by splitting or double formation." ; rdfs:label "Bifid penis" ; rdfs:subClassOf obo:HP_0000036 . obo:HP_0100600 obo:IAO_0000115 "A partial or complete positional exchange between the penis and the scrotum, with positioning of the scrotum superior to the penis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:19:57Z" ; oboInOwl:hasDbXref "MSH:C536650", "SNOMEDCT_US:312005008", "UMLS:C1868854" ; oboInOwl:hasExactSynonym "Prepenile scrotum" ; oboInOwl:id "HP:0100600" ; a owl:Class ; rdfs:label "Penoscrotal transposition" ; rdfs:subClassOf obo:HP_0000036, obo:HP_0000045 . obo:HP_0100601 obo:IAO_0000115 "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:26:33Z" ; oboInOwl:hasDbXref "MSH:D004461", "SNOMEDCT_US:15938005", "UMLS:C0013537" ; oboInOwl:id "HP:0100601" ; a owl:Class ; rdfs:label "Eclampsia" ; rdfs:subClassOf obo:HP_0100603 . obo:HP_0100602 obo:IAO_0000115 "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:26:57Z" ; oboInOwl:hasDbXref "MSH:D011225", "SNOMEDCT_US:15394000", "SNOMEDCT_US:398254007", "UMLS:C0032914" ; oboInOwl:hasExactSynonym "Pre-eclampsia" ; oboInOwl:id "HP:0100602" ; a owl:Class ; rdfs:label "Preeclampsia" ; rdfs:subClassOf obo:HP_0100603 . obo:HP_0100603 obo:IAO_0000115 "Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:27:41Z" ; oboInOwl:hasDbXref "MSH:D011225", "SNOMEDCT_US:15394000", "SNOMEDCT_US:398254007", "UMLS:C0032914" ; oboInOwl:hasExactSynonym "Hypertensive disorder of pregnancy", "Toxaemia of pregnancy" ; oboInOwl:id "HP:0100603" ; a owl:Class ; rdfs:label "Toxemia of pregnancy" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0100604 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the lip." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T05:46:46Z" ; oboInOwl:hasDbXref "MSH:D008048", "NCIT:C3262", "SNOMEDCT_US:126770008", "UMLS:C0023761", "UMLS:C4020706" ; oboInOwl:hasExactSynonym "Lip tumor", "Lip tumour" ; oboInOwl:hasRelatedSynonym "Neoplasia of the lip", "Tumor of the lip", "Tumour of the lip" ; oboInOwl:id "HP:0100604" ; a owl:Class ; rdfs:label "Neoplasm of the lip" ; rdfs:subClassOf obo:HP_0000159, obo:HP_0011793 . obo:HP_0100605 dcterms:creator ; oboInOwl:creation_date "2010-12-27T06:07:16Z" ; oboInOwl:hasDbXref "MSH:D007822", "NCIT:C3262", "SNOMEDCT_US:126692004", "UMLS:C0023055" ; oboInOwl:id "HP:0100605" ; a owl:Class ; rdfs:label "Neoplasm of the larynx" ; rdfs:subClassOf obo:HP_0001600, obo:HP_0100606 . obo:HP_0100606 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the respiratory system." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T06:08:41Z" ; oboInOwl:hasDbXref "MSH:D012142", "NCIT:C3262", "SNOMEDCT_US:126667002", "SNOMEDCT_US:448708002", "UMLS:C0035244" ; oboInOwl:hasExactSynonym "Respiratory system tumor", "Respiratory system tumour" ; oboInOwl:id "HP:0100606" ; a owl:Class ; rdfs:label "Neoplasm of the respiratory system" ; rdfs:subClassOf obo:HP_0002086, obo:HP_0011793 . obo:HP_0100607 obo:IAO_0000115 "Pain during menstruation that interferes with daily activities." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T06:13:30Z" ; oboInOwl:hasDbXref "MSH:D004412", "SNOMEDCT_US:266599000", "SNOMEDCT_US:289900009", "SNOMEDCT_US:431416001", "UMLS:C0013390" ; oboInOwl:hasExactSynonym "Painful menstruation" ; oboInOwl:id "HP:0100607" ; a owl:Class ; rdfs:label "Dysmenorrhea" ; rdfs:subClassOf obo:HP_0000858 . obo:HP_0100608 obo:IAO_0000115 "Bleeding at irregular intervals." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T06:14:01Z" ; oboInOwl:hasDbXref "MSH:D008796", "SNOMEDCT_US:19155002", "SNOMEDCT_US:237130006", "SNOMEDCT_US:64996003", "UMLS:C0025874" ; oboInOwl:hasExactSynonym "Abnormal uterus bleeding", "Intermenstrual bleeding", "Menstrual spotting" ; oboInOwl:id "HP:0100608" ; a owl:Class ; rdfs:label "Metrorrhagia" ; rdfs:subClassOf obo:HP_0000140 . obo:HP_0100609 obo:IAO_0100001 "HP:0000132" ; oboInOwl:id "HP:0100609" ; a owl:Class ; rdfs:label "obsolete Hypermenorrhea" ; owl:deprecated true . obo:HP_0100610 obo:IAO_0000115 "A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy." ; dcterms:creator ; oboInOwl:creation_date "2010-12-27T06:17:13Z" ; oboInOwl:hasDbXref "UMLS:C4022014" ; oboInOwl:hasExactSynonym "High blood phenylalanine level in mother" ; oboInOwl:id "HP:0100610" ; a owl:Class ; rdfs:label "Maternal hyperphenylalaninemia" ; rdfs:subClassOf obo:HP_0002686, obo:HP_0010893 . obo:HP_0100611 obo:IAO_0000115 "The presence of many cysts in the glomerulus of the kidney related to dilatation of the Bowman's capsule." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T10:23:07Z" ; oboInOwl:hasDbXref "UMLS:C4020705", "UMLS:C4022013" ; oboInOwl:hasRelatedSynonym "Glomerulocystic kidney disease" ; oboInOwl:id "HP:0100611" ; a owl:Class ; rdfs:comment "Glomerular cysts, defined as Bowman space dilatation greater than 2 to 3 times normal size, are found in disorders of diverse etiology and with a spectrum of clinical manifestations. The term glomerulocystic kidney refers to a kidney with greater than 5% cystic glomeruli." ; rdfs:label "Multiple glomerular cysts" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0100612 obo:IAO_0000115 "Neoplasm involving odontogenic cells, an odontogenic tumor." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:03:36Z" ; oboInOwl:hasDbXref "MSH:D009808", "NCIT:C3286", "SNOMEDCT_US:127578009", "SNOMEDCT_US:3833004", "UMLS:C0028880" ; oboInOwl:hasExactSynonym "Odontogenic tumor", "Odontogenic tumour" ; oboInOwl:id "HP:0100612" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "Examples for odontogenic neoplasia are Adenomatoid odontogenic tumors, Ameloblastomas, Calcifying epithelial odontogenic tumors, Calcifying odontogenic cysts, Dentigerous cysts, Odontogenic keratocysts, Dontogenic myxomas, Odontomas." ; rdfs:label "Odontogenic neoplasm" ; rdfs:subClassOf obo:HP_0000164, obo:HP_0100649 . obo:HP_0100613 obo:IAO_0000115 "Death between the age of 16 and 40 years." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:12:21Z" ; oboInOwl:hasDbXref "UMLS:C4022012" ; oboInOwl:hasExactSynonym "Death in early adulthood" ; oboInOwl:id "HP:0100613" ; a owl:Class ; rdfs:label "Death in early adulthood" ; rdfs:subClassOf obo:HP_0033763 . obo:HP_0100614 obo:IAO_0000115 "A general term for inflammation of the muscles without respect to the underlying cause." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:14:59Z" ; oboInOwl:hasDbXref "MSH:D009220", "SNOMEDCT_US:128496001", "SNOMEDCT_US:26889001", "UMLS:C0027121" ; oboInOwl:hasExactSynonym "Muscle inflammation" ; oboInOwl:id "HP:0100614" ; a owl:Class ; rdfs:comment "Many such conditions are considered likely to be caused by autoimmune conditions, rather than directly due to infection, although autoimmune conditions can be activated or exacerbated by infections. It is also a documented side effect of the lipid-lowering drugs such as statins and fibrates. Elevation of creatine kinase in blood is indicative of myositis." ; rdfs:label "Myositis" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001015 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100615 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the ovary." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:37:01Z" ; oboInOwl:hasBroadSynonym "Ovarian cancer" ; oboInOwl:hasDbXref "MSH:D010051", "NCIT:C3262", "SNOMEDCT_US:123843001", "UMLS:C0919267" ; oboInOwl:hasExactSynonym "Neoplasm of the ovaries", "Neoplasm of the ovary", "Ovarian tumor", "Ovarian tumour" ; oboInOwl:hasRelatedSynonym "Ovarian neoplasia" ; oboInOwl:id "HP:0100615" ; a owl:Class ; rdfs:label "Ovarian neoplasm" ; rdfs:subClassOf obo:HP_0000137, obo:HP_0010785 . obo:HP_0100616 obo:IAO_0000115 "The presence of a teratoma of the testis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:42:18Z" ; oboInOwl:hasDbXref "MSH:C562472", "NCIT:C3403", "UMLS:C0238451" ; oboInOwl:id "HP:0100616" ; a owl:Class ; rdfs:comment "An encapsulated tumor of the testis with tissue or organ components resembling normal derivatives of all three germ layers." ; rdfs:label "Testicular teratoma" ; rdfs:subClassOf obo:HP_0009792, obo:HP_0010788 . obo:HP_0100617 obo:IAO_0000115 "The presence of a seminoma, an undifferentiated germ cell tumor of the testis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:42:18Z" ; oboInOwl:hasDbXref "MSH:D018239", "NCIT:C9309", "SNOMEDCT_US:255107005", "SNOMEDCT_US:36741007", "SNOMEDCT_US:443675005", "UMLS:C0036631" ; oboInOwl:id "HP:0100617" ; a owl:Class ; rdfs:label "Testicular seminoma" ; rdfs:subClassOf obo:HP_0010788, obo:HP_0100620 . obo:HP_0100618 obo:IAO_0000115 "The presence of a neoplasm of the testis with origin in a Leydig cell." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:42:18Z" ; oboInOwl:hasDbXref "NCIT:C3188", "UMLS:C4022011" ; oboInOwl:id "HP:0100618" ; a owl:Class ; rdfs:label "Leydig cell neoplasia" ; rdfs:subClassOf obo:HP_0010788, obo:HP_0010789 . obo:HP_0100619 obo:IAO_0000115 "The presence of a neoplasm of the testis with origin in a Sertoli cell." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:42:18Z" ; oboInOwl:hasDbXref "NCIT:C39976", "UMLS:C4020704" ; oboInOwl:hasRelatedSynonym "Sertoli cell neoplasia" ; oboInOwl:id "HP:0100619" ; a owl:Class ; rdfs:label "Sertoli cell neoplasm" ; rdfs:subClassOf obo:HP_0010788 . obo:HP_0100620 obo:IAO_0000115 "A type of undifferentiated germ cell tumor that may be benign or malignant." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:45:44Z" ; oboInOwl:hasDbXref "MSH:D018237", "SNOMEDCT_US:28307001", "UMLS:C0206660" ; oboInOwl:id "HP:0100620" ; a owl:Class ; rdfs:label "Germinoma" ; rdfs:subClassOf obo:HP_0100728 . obo:HP_0100621 obo:IAO_0000115 "The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T11:47:47Z" ; oboInOwl:hasDbXref "MSH:D004407", "NCIT:C2996", "SNOMEDCT_US:60718004", "UMLS:C0013377" ; oboInOwl:id "HP:0100621" ; a owl:Class ; rdfs:label "Dysgerminoma" ; rdfs:subClassOf obo:HP_0100615, obo:HP_0100620 . obo:HP_0100622 obo:IAO_0000115 "A seizure during pregnancy." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T12:03:21Z" ; oboInOwl:hasDbXref "UMLS:C4022010" ; oboInOwl:hasExactSynonym "Maternal seizures" ; oboInOwl:id "HP:0100622" ; a owl:Class ; rdfs:label "Maternal seizure" ; rdfs:subClassOf obo:HP_0001250, obo:HP_0002686 . obo:HP_0100623 obo:IAO_0000115 "A structural anomaly of the corpus cavernosum, the erectile tissue of the penis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T12:47:15Z" ; oboInOwl:hasDbXref "UMLS:C4022009" ; oboInOwl:hasExactSynonym "Abnormality of corpus cavernosum" ; oboInOwl:id "HP:0100623" ; a owl:Class ; rdfs:label "Abnormal corpus cavernosum morphology" ; rdfs:subClassOf obo:HP_0000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100624 dcterms:creator ; oboInOwl:creation_date "2010-12-28T12:47:33Z" ; oboInOwl:hasDbXref "UMLS:C4022008" ; oboInOwl:id "HP:0100624" ; a owl:Class ; rdfs:label "Corpus cavernosum sclerosis" ; rdfs:subClassOf obo:HP_0100623 . obo:HP_0100625 dcterms:creator ; oboInOwl:creation_date "2010-12-28T04:14:55Z" ; oboInOwl:hasDbXref "UMLS:C4020962" ; oboInOwl:hasExactSynonym "Wide rib cage", "Wide thorax" ; oboInOwl:id "HP:0100625" ; a owl:Class ; rdfs:label "Enlarged thorax" ; rdfs:subClassOf obo:HP_0001547 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100626 dcterms:creator ; oboInOwl:creation_date "2010-12-28T04:59:16Z" ; oboInOwl:hasDbXref "MSH:D058625", "SNOMEDCT_US:235886005", "UMLS:C2936476" ; oboInOwl:hasExactSynonym "Chronic liver failure" ; oboInOwl:id "HP:0100626" ; a owl:Class ; rdfs:label "Chronic hepatic failure" ; rdfs:subClassOf obo:HP_0001399 . obo:HP_0100627 obo:IAO_0000115 "A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina)." ; dcterms:creator ; oboInOwl:creation_date "2010-12-28T05:02:59Z" ; oboInOwl:hasDbXref "UMLS:C4020961" ; oboInOwl:hasExactSynonym "Displacement of the external urethral orifice", "Displacement of the male external urethral orifice" ; oboInOwl:id "HP:0100627" ; a owl:Class ; rdfs:comment "Congenital misplacement of the urethral orifice is called hypospadias when it is located in the underside (ventral aspect) of the penis, and epispadias when located in the dorsum (upper aspect)." ; rdfs:label "Displacement of the urethral meatus" ; rdfs:subClassOf obo:HP_0000795, obo:HP_0032076 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002181 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0012240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100628 obo:IAO_0000115 "The presence of a diverticulum of the esophagus." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T02:22:08Z" ; oboInOwl:hasDbXref "MSH:D004936", "SNOMEDCT_US:204667006", "SNOMEDCT_US:414133009", "UMLS:C0014854" ; oboInOwl:hasExactSynonym "Esophageal pouch" ; oboInOwl:id "HP:0100628" ; a owl:Class ; rdfs:comment "A diverticulum is a blind ended outpouching through the wall of a tubular organ or bounded cavity." ; rdfs:label "Esophageal diverticulum" ; rdfs:subClassOf obo:HP_0002031 . obo:HP_0100629 obo:IAO_0000115 "A congenital malformation with a cleft (gap or opening) in the midline of the face." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T02:23:01Z" ; oboInOwl:hasDbXref "UMLS:C4022007" ; oboInOwl:hasExactSynonym "Midline facial cleft" ; oboInOwl:id "HP:0100629" ; a owl:Class ; rdfs:comment "Midline facial clefts correspond to Tessier number 0,14, and 30." ; rdfs:label "Midline facial cleft" ; rdfs:subClassOf obo:HP_0002006 . obo:HP_0100630 dcterms:creator ; oboInOwl:creation_date "2010-12-29T02:23:48Z" ; oboInOwl:hasDbXref "MSH:D009303", "NCIT:C3262", "SNOMEDCT_US:126680004", "UMLS:C0027439" ; oboInOwl:hasExactSynonym "Nasopharyngeal neoplasm", "Neoplasm of the nasopharynx" ; oboInOwl:hasNarrowSynonym "Tumor of the nasopharynx", "Tumour of the nasopharynx" ; oboInOwl:id "HP:0100630" ; a owl:Class ; rdfs:label "Neoplasia of the nasopharynx" ; rdfs:subClassOf obo:HP_0001739, obo:HP_0100606 . obo:HP_0100631 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the adrenal gland." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T02:27:47Z" ; oboInOwl:hasDbXref "MSH:D000310", "NCIT:C3262", "SNOMEDCT_US:127021009", "UMLS:C0001624" ; oboInOwl:hasExactSynonym "Adrenal neoplasia" ; oboInOwl:id "HP:0100631" ; a owl:Class ; rdfs:label "Neoplasm of the adrenal gland" ; rdfs:subClassOf obo:HP_0011732, obo:HP_0100568 . obo:HP_0100632 obo:IAO_0000115 "The presence of a piece lung tissue which is not attached to the pulmonary blood supply and does not communicate with the other lung tissue (not connected to the standard bronchial airways and not performing a function in respiration)." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:05:08Z" ; oboInOwl:hasDbXref "MSH:D001998", "SNOMEDCT_US:18620009", "UMLS:C0006288", "UMLS:C4020703" ; oboInOwl:hasRelatedSynonym "Cystic lung lesion" ; oboInOwl:id "HP:0100632" ; a owl:Class ; rdfs:label "Pulmonary sequestration" ; rdfs:subClassOf obo:HP_4000059 . obo:HP_0100633 obo:IAO_0000115 "Inflammation of the esophagus." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:09:23Z" ; oboInOwl:hasDbXref "MEDDRA:10030216", "MSH:D004941", "SNOMEDCT_US:16761005", "UMLS:C0014868" ; oboInOwl:hasExactSynonym "Inflammation of the esophagus", "Inflammation of the oesophagus", "Oesophagitis" ; oboInOwl:id "HP:0100633" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Esophagitis" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0004386 . obo:HP_0100634 obo:IAO_0000115 "A tumor that originates from a neuroendocrine cell." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:12:37Z" ; oboInOwl:hasDbXref "MSH:D018358", "SNOMEDCT_US:128928004", "SNOMEDCT_US:255046005", "UMLS:C0206754" ; oboInOwl:hasExactSynonym "Neuroendocrine neoplasia" ; oboInOwl:id "HP:0100634" ; a owl:Class ; rdfs:comment "Neuroendocrine tumors are often diagnosed incidentally or when patients present with symptoms related to hormone production and/or tumor burden." ; rdfs:label "Neuroendocrine neoplasm" ; rdfs:subClassOf obo:HP_0100007, obo:HP_0100568 . obo:HP_0100635 obo:IAO_0000115 "A paraganglioma (a neuroendocrine neoplasm) originating in a carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:20:58Z" ; oboInOwl:hasDbXref "UMLS:C4022005" ; oboInOwl:id "HP:0100635" ; a owl:Class ; rdfs:label "Carotid paraganglioma" ; rdfs:subClassOf obo:HP_0002864, obo:HP_0005344 . obo:HP_0100636 obo:IAO_0000115 "A rare paranglioma of the lung, tumors that arise from extra-adrenal chromaffin cells." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:23:34Z" ; oboInOwl:hasDbXref "UMLS:C4022004" ; oboInOwl:id "HP:0100636" ; a owl:Class ; rdfs:label "Pulmonary paraglioma" ; rdfs:subClassOf obo:HP_0002668, obo:HP_0100526 . obo:HP_0100637 obo:IAO_0100001 "HP:0012720" ; oboInOwl:id "HP:0100637" ; a owl:Class ; rdfs:label "obsolete Neoplasia of the nose" ; owl:deprecated true . obo:HP_0100638 obo:IAO_0000115 "A neoplasm originating in the pharynx." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:31:55Z" ; oboInOwl:hasAlternativeId "HP:0030073" ; oboInOwl:hasDbXref "MSH:D010610", "NCIT:C3262", "SNOMEDCT_US:126685009", "UMLS:C0031347" ; oboInOwl:hasExactSynonym "Neoplasia of the pharynx", "Pharyngeal neoplasm" ; oboInOwl:hasNarrowSynonym "Tumor of the pharynx", "Tumour of the pharynx" ; oboInOwl:id "HP:0100638" ; a owl:Class ; rdfs:comment "Tumors of pharynx may present with nonspecific findings such as otalgia or unilateral otitis media." ; rdfs:label "Neoplasm of the pharynx" ; rdfs:subClassOf obo:HP_0100630 . obo:HP_0100639 obo:IAO_0000115 "A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:45:28Z" ; oboInOwl:hasExactSynonym "Abnormal erection", "Erectile abnormalities" ; oboInOwl:id "HP:0100639" ; a owl:Class ; rdfs:label "Erectile dysfunction" ; rdfs:subClassOf obo:HP_0040307 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0043084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100640 obo:IAO_0000115 "Presence of a cyst (sac-like structure) located in the larynx." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:48:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:195867000", "UMLS:C0339880" ; oboInOwl:id "HP:0100640" ; a owl:Class ; rdfs:label "Laryngeal cyst" ; rdfs:subClassOf obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100641 obo:IAO_0000115 "The presence of a neoplasm of the adrenal cortex." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:53:58Z" ; oboInOwl:hasDbXref "MSH:D000306", "NCIT:C3262", "SNOMEDCT_US:127022002", "SNOMEDCT_US:18365006", "UMLS:C0001618" ; oboInOwl:hasExactSynonym "Cortical adrenal neoplasia" ; oboInOwl:id "HP:0100641" ; a owl:Class ; rdfs:label "Neoplasm of the adrenal cortex" ; rdfs:subClassOf obo:HP_0100631 . obo:HP_0100642 obo:IAO_0000115 "The presence of a neoplasm of the adrenal medulla." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:54:15Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:127023007", "UMLS:C0596046" ; oboInOwl:hasExactSynonym "Medullar adrenal neoplasia" ; oboInOwl:id "HP:0100642" ; a owl:Class ; rdfs:label "Neoplasm of the adrenal medulla" ; rdfs:subClassOf obo:HP_0100631 . obo:HP_0100643 obo:IAO_0000115 "An anomaly of the color of the nail." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T05:59:15Z" ; oboInOwl:hasDbXref "UMLS:C4020960" ; oboInOwl:hasExactSynonym "Abnormality of nail color", "Abnormality of nail colour", "Nail dyschromia" ; oboInOwl:id "HP:0100643" ; a owl:Class ; rdfs:label "Abnormality of nail color" ; rdfs:subClassOf obo:HP_0001597 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000014 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001705 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100644 obo:IAO_0000115 "Brown or black discoloration of the nails." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:00:12Z" ; oboInOwl:hasDbXref "MEDDRA:10058330", "SNOMEDCT_US:402633003", "UMLS:C1142305" ; oboInOwl:id "HP:0100644" ; a owl:Class ; rdfs:label "Melanonychia" ; rdfs:subClassOf obo:HP_0100643 . obo:HP_0100645 obo:IAO_0000115 "Anterior vaginal wall prolapse with bulging of the bladder into the vagina." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:05:01Z" ; oboInOwl:hasDbXref "ICD-9:618.00", "SNOMEDCT_US:252005008", "UMLS:C1394494" ; oboInOwl:hasExactSynonym "Bladder hernia", "Bladder prolapse", "Dropped bladder", "Prolapsed bladder" ; oboInOwl:id "HP:0100645" ; a owl:Class ; rdfs:comment "Cystocele occurs owing to weakening and stretching of the suppoortive tissue between the bladder and the vaginal wall." ; rdfs:label "Cystocele" ; rdfs:subClassOf obo:HP_0025487, obo:HP_0031607, obo:HP_0100672 . obo:HP_0100646 obo:IAO_0000115 "Inflammation of the thyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:08:32Z" ; oboInOwl:hasDbXref "MSH:D013966", "SNOMEDCT_US:82119001", "UMLS:C0040147" ; oboInOwl:hasExactSynonym "Thyroid gland inflammation" ; oboInOwl:id "HP:0100646" ; a owl:Class ; rdfs:label "Thyroiditis" ; rdfs:subClassOf obo:HP_0011772, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100647 obo:IAO_0000115 "An autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis). This is caused by autoantibodies to the TSH-receptor (TSHR-Ab) that activate that TSH-receptor (TSHR), thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter). The resulting state of hyperthyroidism can cause a dramatic constellation of neuropsychological and physical signs and symptoms, which can severely compromise the patients." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:08:53Z" ; oboInOwl:hasDbXref "MSH:D006111", "SNOMEDCT_US:353295004", "SNOMEDCT_US:55807009", "UMLS:C0018213" ; oboInOwl:hasExactSynonym "Morbus Basedow" ; oboInOwl:id "HP:0100647" ; a owl:Class ; rdfs:label "Graves disease" ; rdfs:subClassOf obo:HP_0011784 . obo:HP_0100648 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the tongue." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:14:32Z" ; oboInOwl:hasDbXref "MSH:D014062", "NCIT:C3262", "SNOMEDCT_US:126778001", "UMLS:C0040411" ; oboInOwl:id "HP:0100648" ; a owl:Class ; rdfs:label "Neoplasm of the tongue" ; rdfs:subClassOf obo:HP_0000157, obo:HP_0100649 . obo:HP_0100649 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the oral cavity." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:15:14Z" ; oboInOwl:hasAlternativeId "HP:0012290" ; oboInOwl:hasBroadSynonym "Lesion of oral cavity" ; oboInOwl:hasDbXref "MSH:D009062", "NCIT:C3262", "SNOMEDCT_US:1071000119107", "SNOMEDCT_US:126797001", "SNOMEDCT_US:235075007", "UMLS:C0026640", "UMLS:C0149744", "UMLS:C4280289" ; oboInOwl:hasExactSynonym "Mouth neoplasm", "Mouth tumor", "Mouth tumour", "Neoplasm of the mouth" ; oboInOwl:hasNarrowSynonym "Tumor of oral cavity", "Tumour of oral cavity" ; oboInOwl:id "HP:0100649" ; a owl:Class ; rdfs:label "Neoplasm of the oral cavity" ; rdfs:subClassOf obo:HP_0000163, obo:HP_0011793 . obo:HP_0100650 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the vagina." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:34:41Z" ; oboInOwl:hasDbXref "MSH:D014625", "NCIT:C3262", "SNOMEDCT_US:126921000", "UMLS:C0042258", "UMLS:C0750081" ; oboInOwl:hasExactSynonym "Vaginal tumor", "Vaginal tumour" ; oboInOwl:hasRelatedSynonym "Vaginal neoplasia" ; oboInOwl:id "HP:0100650" ; a owl:Class ; rdfs:label "Vaginal neoplasm" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0033020 . obo:HP_0100651 obo:IAO_0000115 "A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin." ; dcterms:creator ; oboInOwl:creation_date "2010-12-29T06:37:55Z" ; oboInOwl:hasDbXref "MSH:D003922", "SNOMEDCT_US:46635009", "UMLS:C0011854" ; oboInOwl:hasExactSynonym "Diabetes mellitus Type I", "Juvenile diabetes mellitus", "Type 1 diabetes", "Type I diabetes" ; oboInOwl:hasRelatedSynonym "Insulin-dependent diabetes mellitus" ; oboInOwl:id "HP:0100651" ; a owl:Class ; rdfs:comment "The onset of type 1 diabetes is typically during adolescence, but it can develop at any age." ; rdfs:label "Type I diabetes mellitus" ; rdfs:subClassOf obo:HP_0000819 . obo:HP_0100653 obo:IAO_0000115 "Inflammation of the optic nerve." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T09:56:38Z" ; oboInOwl:hasDbXref "MSH:D009902", "SNOMEDCT_US:66760008", "UMLS:C0029134" ; oboInOwl:id "HP:0100653" ; a owl:Class ; rdfs:comment "Optic neuritis can cause loss of vision because of swelling and destruction of the myelin sheath covering the optic nerve and/or direct axonal damage." ; rdfs:label "Optic neuritis" ; rdfs:subClassOf obo:HP_0000587, obo:HP_0033429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000941 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100654 obo:IAO_0000115 "Optic neuritis that occurs in the section of the optic nerve located behind the eyeball." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T09:57:09Z" ; oboInOwl:hasDbXref "MSH:D009902", "SNOMEDCT_US:230507009", "UMLS:C0085582" ; oboInOwl:hasExactSynonym "Retrobulbar neuritis" ; oboInOwl:id "HP:0100654" ; a owl:Class ; rdfs:label "Retrobulbar optic neuritis" ; rdfs:subClassOf obo:HP_0100653 . obo:HP_0100656 obo:IAO_0000115 "Failure to close of the chest and abdominal wall likely caused by the failure of the ventral wall to close during week 4 of development." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T10:04:18Z" ; oboInOwl:hasDbXref "UMLS:C4022002" ; oboInOwl:hasExactSynonym "Thoracoabdominal schisis" ; oboInOwl:id "HP:0100656" ; a owl:Class ; rdfs:comment "May be accompanied by thoracic ectopia cordis and gastroschisis." ; rdfs:label "Thoracoabdominal wall defect" ; rdfs:subClassOf obo:HP_0000765, obo:HP_0010866 . obo:HP_0100657 obo:IAO_0000115 "Congenital protrusion of the abdominal or thoracic viscera, usually with a defect of the sternum and ribs as well as of the abdominal walls." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T10:07:54Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:44518003", "UMLS:C0266682" ; oboInOwl:hasExactSynonym "Celosomia", "Kelosomia" ; oboInOwl:id "HP:0100657" ; a owl:Class ; rdfs:label "Thoracoabdominal eventration" ; rdfs:subClassOf obo:HP_0100656 . obo:HP_0100658 obo:IAO_0000115 "A bacterial infection and inflammation of the skin und subcutaneous tissues." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T10:11:51Z" ; oboInOwl:hasAlternativeId "HP:0003553" ; oboInOwl:hasDbXref "MSH:D002481", "MSH:D017192", "SNOMEDCT_US:128045006", "SNOMEDCT_US:128936008", "SNOMEDCT_US:385627004", "UMLS:C0007642", "UMLS:C0162627" ; oboInOwl:hasExactSynonym "Bacterial infection of skin", "Skin infection" ; oboInOwl:hasRelatedSynonym "Skin infections" ; oboInOwl:id "HP:0100658" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "In contrast to impetigo, which is a very superficial skin infection, cellulitis involves both the dermis and the underlying subcutaneous tissue." ; rdfs:label "Cellulitis" ; rdfs:subClassOf obo:HP_0003549 . obo:HP_0100659 obo:IAO_0000115 "An anomaly of the cerebral blood vessels." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T11:39:15Z" ; oboInOwl:hasDbXref "UMLS:C4022001" ; oboInOwl:hasExactSynonym "Abnormality of the cerebral blood vessels", "Abnormality of the cerebral vasculature" ; oboInOwl:id "HP:0100659" ; a owl:Class ; rdfs:label "Abnormal cerebral vascular morphology" ; rdfs:subClassOf obo:HP_0012443, obo:HP_0025015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100660 obo:IAO_0000115 "A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T11:46:50Z" ; oboInOwl:hasDbXref "MSH:D020820", "SNOMEDCT_US:9748009", "UMLS:C0013384" ; oboInOwl:hasExactSynonym "Disorder of involuntary muscle movements", "Dyskinesis" ; oboInOwl:hasRelatedSynonym "Dyskinesias" ; oboInOwl:id "HP:0100660" ; a owl:Class ; rdfs:label "Dyskinesia" ; rdfs:subClassOf obo:HP_0100022 . obo:HP_0100661 obo:IAO_0000115 "A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T11:53:47Z" ; oboInOwl:hasDbXref "MSH:D014277", "SNOMEDCT_US:31681005", "UMLS:C0040997" ; oboInOwl:hasExactSynonym "Tic douloureux" ; oboInOwl:id "HP:0100661" ; a owl:Class ; rdfs:label "Trigeminal neuralgia" ; rdfs:subClassOf obo:HP_0031911, obo:HP_0033345 . obo:HP_0100662 obo:IAO_0000115 "Inflammation of cartilage." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T12:57:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46176001", "UMLS:C0008439" ; oboInOwl:hasExactSynonym "Cartilage inflammation" ; oboInOwl:id "HP:0100662" ; a owl:Class ; rdfs:label "Chondritis" ; rdfs:subClassOf obo:HP_0002763, obo:HP_0012649 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0007844 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100663 obo:IAO_0000115 "A congenital malformation characterized by the union or approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:00:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77471004", "UMLS:C0266677" ; oboInOwl:id "HP:0100663" ; a owl:Class ; rdfs:label "Synotia" ; rdfs:subClassOf obo:HP_0000357 . obo:HP_0100665 obo:IAO_0000115 "Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:09:59Z" ; oboInOwl:hasAlternativeId "HP:0100666" ; oboInOwl:hasDbXref "MSH:D000799", "SNOMEDCT_US:400075008", "SNOMEDCT_US:41291007", "UMLS:C0002994" ; oboInOwl:hasExactSynonym "Angioneurotic oedema", "Angiooedema", "Quincke edema", "Quincke oedema" ; oboInOwl:id "HP:0100665" ; a owl:Class ; rdfs:comment "Apart from the common form, mediated by allergy, it has been reported as a side effect of some medications, in particular ACE inhibitors. Additionally, there are three autosomal dominant inherited forms known, due to mutations in the genes that control the clotting cascade, including the SERPING1 gene, which results in deficiency of the blood protein C1-inhibitor (type I HAE) and the F12 gene, which controls Factor XII (type III HAE). There is an additional type in which C1 levels are normal but C1 function is decreased (type II HAE). All three forms are called hereditary angioedema (HAE) or occasionally by the outdated term 'hereditary angioneurotic edema' (HANE). In all forms of HAE, swelling may also occur in the digestive tract and other organs. It is life-threatening when it involves the larynx due to the potential for asphyxiation." ; rdfs:label "Angioedema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0011276 . obo:HP_0100668 obo:IAO_0000115 "A developmental disorder in which there is a duplication the entire intestine or of a portion of the intestine." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:23:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:3845008", "UMLS:C0266166", "UMLS:C4020702" ; oboInOwl:hasExactSynonym "Bowel duplication" ; oboInOwl:hasRelatedSynonym "Gut duplication" ; oboInOwl:id "HP:0100668" ; a owl:Class ; rdfs:label "Intestinal duplication" ; rdfs:subClassOf obo:HP_0002242, obo:HP_0011140 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000160 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100669 obo:IAO_0000115 "An abnormality of the pigmentation of the mucosa of the mouth." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:25:45Z" ; oboInOwl:hasBroadSynonym "Abnormal color of the oral mucosa", "Abnormal colour of the oral mucosa" ; oboInOwl:hasDbXref "UMLS:C4020959" ; oboInOwl:hasExactSynonym "Abnormal pigmentation of oral cavity", "Abnormal pigmentation of oral mucous membrane", "Abnormal pigmentation of the oral mucosa/gingivae" ; oboInOwl:id "HP:0100669" ; a owl:Class ; rdfs:label "Abnormal pigmentation of the oral mucosa" ; rdfs:subClassOf obo:HP_0011830 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003729 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100670 obo:IAO_0000115 "Coarse appearance of the components of the network of osseous tissue that makes up the cancellous structure of a bone, i.e., thickening of the (usually fine) white lines that are produced by trabeculae in radiograms." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:29:46Z" ; oboInOwl:hasDbXref "UMLS:C4020958" ; oboInOwl:hasExactSynonym "Coarse trabeculation at metaphyses", "Rough bone trabeculation", "Rough trabeculation of bone" ; oboInOwl:id "HP:0100670" ; a owl:Class ; rdfs:label "Coarse metaphyseal trabecularization" ; rdfs:subClassOf obo:HP_0005089, obo:HP_0100671 . obo:HP_0100671 obo:IAO_0000115 "Abnormal structure or form of trabecular bone." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:30:05Z" ; oboInOwl:hasDbXref "UMLS:C4020957" ; oboInOwl:hasExactSynonym "Abnormal shape of spongy bone", "Abnormality of bone trabeculation" ; oboInOwl:id "HP:0100671" ; a owl:Class ; rdfs:label "Abnormal trabecular bone morphology" ; rdfs:subClassOf obo:HP_0003330 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100672 obo:IAO_0000115 "The presence of a hernia of the vagina." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:35:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:397786004", "UMLS:C1442998" ; oboInOwl:id "HP:0100672" ; a owl:Class ; rdfs:label "Vaginal hernia" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0100823 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000643 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000996 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100673 obo:IAO_0000115 "A type of hydrocele testis in which the processus vaginalis remains patent only around the testes, and, as fluid accumulates, it renders the testes impalpable." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:36:39Z" ; oboInOwl:hasDbXref "MSH:D006848", "SNOMEDCT_US:26614003", "SNOMEDCT_US:386152007", "SNOMEDCT_US:55434001", "UMLS:C1720771" ; oboInOwl:id "HP:0100673" ; a owl:Class ; rdfs:comment "\"vaginal\" refers to the tunica vaginalis of the testis, not to the vagina." ; rdfs:label "Vaginal hydrocele" ; rdfs:subClassOf obo:HP_0000034 . obo:HP_0100674 dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:36:39Z" ; oboInOwl:hasDbXref "UMLS:C1456401" ; oboInOwl:id "HP:0100674" ; a owl:Class ; rdfs:comment "\"vaginal\" refers to the tunica vaginalis of the testis, not to the vagina." ; rdfs:label "Vaginal hematocele" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0100675 dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:36:39Z" ; oboInOwl:hasDbXref "UMLS:C4022000" ; oboInOwl:id "HP:0100675" ; a owl:Class ; rdfs:comment "\"vaginal\" refers to the tunica vaginalis of the testis, not to the vagina." ; rdfs:label "Vaginal pyocele" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0100676 dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:36:39Z" ; oboInOwl:hasDbXref "UMLS:C4021999" ; oboInOwl:id "HP:0100676" ; a owl:Class ; rdfs:comment "\"vaginal\" refers to the tunica vaginalis of the testis, not to the vagina." ; rdfs:label "Vaginal lymphocele" ; rdfs:subClassOf obo:HP_0000045 . obo:HP_0100677 obo:IAO_0000115 "Varicosity of veins in the vulval region." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:36:39Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:48868008", "UMLS:C0155796" ; oboInOwl:id "HP:0100677" ; a owl:Class ; rdfs:label "Vulval varicose vein" ; rdfs:subClassOf obo:HP_0000055, obo:HP_0002619 . obo:HP_0100678 obo:IAO_0000115 "The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:43:36Z" ; oboInOwl:hasAlternativeId "HP:0200074" ; oboInOwl:hasDbXref "MEDDRA:10040954", "MSH:D015595", "SNOMEDCT_US:247434009", "UMLS:C0037301" ; oboInOwl:hasExactSynonym "Premature skin wrinkling" ; oboInOwl:hasRelatedSynonym "Wrinkled skin" ; oboInOwl:id "HP:0100678" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Premature skin wrinkling" ; rdfs:subClassOf obo:HP_0007495 . obo:HP_0100679 dcterms:creator ; oboInOwl:creation_date "2010-12-30T01:48:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:297957009", "UMLS:C0558242", "UMLS:C4021998" ; oboInOwl:hasRelatedSynonym "Tight skin" ; oboInOwl:id "HP:0100679" ; a owl:Class ; rdfs:label "Lack of skin elasticity" ; rdfs:subClassOf obo:HP_0010647 . obo:HP_0100681 obo:IAO_0000115 "A developmental disorder in which there is a duplication of a portion of the muscle and submucosa of the esophagus without epithelial duplication." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:08:38Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:66865009", "UMLS:C0266135" ; oboInOwl:id "HP:0100681" ; a owl:Class ; rdfs:comment "Esophageal duplication is a rare cause of mediastinal mass. An esophageal duplication may be a simple epithelial cyst or duplication that contains muscle and submucosa but not epithelium. In most cases, the duplication is located in the lower thrid of the esophagus, and the most common associated symptom is difficulty in swallowing. Esophageal duplication occurs because of maldevelopment of the posterior division of embryonic foregut." ; rdfs:label "Esophageal duplication" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0011140 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001043 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100682 obo:IAO_0000115 "A congenital absence or considerable underdevelopment of the trachea such that communication between the larynx proximally and the alveoli of the lungs distally is lacking." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:09:37Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:53189005", "UMLS:C0265766" ; oboInOwl:id "HP:0100682" ; a owl:Class ; rdfs:comment """Diagnosis can be made if the neonate presents with respiratory distress at birth, unable to produce an audible cry in spite of an obvious physical effort, and cannot be intubated but shows some improvement when ventilated by bag and mask.""" ; rdfs:label "Tracheal atresia" ; rdfs:subClassOf obo:HP_0002777 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001819 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100684 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of a salivary gland." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:20:38Z" ; oboInOwl:hasDbXref "MSH:D012468", "NCIT:C3262", "SNOMEDCT_US:235132004", "SNOMEDCT_US:255072001", "UMLS:C0036095", "UMLS:C0220636" ; oboInOwl:hasExactSynonym "Salivary gland neoplasia" ; oboInOwl:hasNarrowSynonym "Tumor of salivary gland", "Tumour of salivary gland" ; oboInOwl:hasRelatedSynonym "Cancer of salivary gland" ; oboInOwl:id "HP:0100684" ; a owl:Class ; rdfs:label "Salivary gland neoplasm" ; rdfs:subClassOf obo:HP_0010286, obo:HP_0100649 . obo:HP_0100685 obo:IAO_0000115 "An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibres connecting periosteum to bone." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:25:32Z" ; oboInOwl:hasDbXref "UMLS:C4020701", "UMLS:C4021997" ; oboInOwl:hasExactSynonym "Abnormal Sharpey fibre morphology", "Abnormality of Sharpey fibers", "Abnormality of Sharpey fibres" ; oboInOwl:hasRelatedSynonym "Enthesis abnormality" ; oboInOwl:id "HP:0100685" ; a owl:Class ; rdfs:label "Abnormal Sharpey fiber morphology" ; rdfs:subClassOf obo:HP_0003549 . obo:HP_0100686 dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:27:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:359643005", "UMLS:C1282952" ; oboInOwl:hasExactSynonym "Inflammation of sharpey fibers", "Inflammation of sharpey fibres" ; oboInOwl:id "HP:0100686" ; a owl:Class ; rdfs:label "Enthesitis" ; rdfs:subClassOf obo:HP_0100685 . obo:HP_0100687 obo:IAO_0000115 "The presence of an extra auricle on one or both sides of the head." ; dcterms:creator ; oboInOwl:creation_date "2010-12-30T02:30:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:35547002", "UMLS:C0266611" ; oboInOwl:id "HP:0100687" ; a owl:Class ; rdfs:label "Polyotia" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0100689 obo:IAO_0000115 "A decreased anteroposterior thickness of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2011-02-18T04:40:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:423459005", "UMLS:C1096274" ; oboInOwl:hasExactSynonym "Thin cornea" ; oboInOwl:id "HP:0100689" ; a owl:Class ; rdfs:label "Decreased corneal thickness" ; rdfs:subClassOf obo:HP_0011486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000592 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100690 dcterms:creator ; oboInOwl:creation_date "2011-02-18T04:52:59Z" ; oboInOwl:hasDbXref "UMLS:C4021996" ; oboInOwl:id "HP:0100690" ; a owl:Class ; rdfs:label "Mosaic central corneal dystrophy" ; rdfs:subClassOf obo:HP_0007836, obo:HP_0007881 . obo:HP_0100691 dcterms:creator ; oboInOwl:creation_date "2011-02-18T04:58:48Z" ; oboInOwl:hasDbXref "UMLS:C4021995" ; oboInOwl:id "HP:0100691" ; a owl:Class ; rdfs:label "Abnormality of the curvature of the cornea" ; rdfs:subClassOf obo:HP_0000481 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001591 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100692 obo:IAO_0000115 "An increase in the degree of curvature of the cornea compared to normal." ; dcterms:creator ; oboInOwl:creation_date "2011-02-18T05:01:31Z" ; oboInOwl:hasDbXref "UMLS:C4020956" ; oboInOwl:hasExactSynonym "Steep corneal curvature" ; oboInOwl:id "HP:0100692" ; a owl:Class ; rdfs:label "Increased corneal curvature" ; rdfs:subClassOf obo:HP_0100691 . obo:HP_0100693 obo:IAO_0000115 "Tremulousness of the iris on movement of the eye, occurring in subluxation of the lens." ; dcterms:creator ; oboInOwl:creation_date "2011-02-18T05:11:16Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:118166004", "UMLS:C0423320" ; oboInOwl:id "HP:0100693" ; a owl:Class ; rdfs:label "Iridodonesis" ; rdfs:subClassOf obo:HP_0000525 . obo:HP_0100694 obo:IAO_0000115 "Twisted position of the tibia (shin bone) associated with pathological rotation of the leg." ; dcterms:creator ; oboInOwl:creation_date "2011-03-28T05:04:08Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:249785006", "UMLS:C0426900" ; oboInOwl:id "HP:0100694" ; a owl:Class ; rdfs:comment "Normally, lateral rotation of the tibia increases from approximately 5 degrees at birth to approximately 15 degrees at maturity. Tibial torsion is the most common cause of intoeing. In a study by Mullaji et al to determine tibial torsion norms, individuals in India were found to have less tibial torsion than Caucasians but about the same amount as the Japanese population. The differences in normal tibial torsion values are expected to be caused by the different lifestyles and postures of the different populations, such as cross-legged sitting positions." ; rdfs:label "Tibial torsion" ; rdfs:subClassOf obo:HP_0002992 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002155 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100695 obo:IAO_0000115 "Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise ." ; dcterms:creator ; oboInOwl:creation_date "2011-03-28T04:43:32Z" ; oboInOwl:hasDbXref "MSH:D065134", "SNOMEDCT_US:234102003", "UMLS:C0398370" ; oboInOwl:id "HP:0100695" ; a owl:Class ; rdfs:comment "The pattern of fat deposition is most often bilateral, symmetrical and usually from the waist to a distinct line just above the ankles." ; rdfs:label "Lipedema" ; rdfs:subClassOf obo:HP_0009126 . obo:HP_0100697 obo:IAO_0000115 "A form of malignant cancer of the connective tissue surrounding nerves. Given its origin and behavior, it is classified as a sarcoma." ; dcterms:creator ; oboInOwl:creation_date "2011-03-29T11:40:44Z" ; oboInOwl:hasDbXref "MSH:D009442", "MSH:D018319", "NCIT:C3798", "SNOMEDCT_US:19897006", "SNOMEDCT_US:404037002", "SNOMEDCT_US:77418004", "UMLS:C0206729", "UMLS:C0751690" ; oboInOwl:hasExactSynonym "Malignant peripheral nerve sheath tumor", "Malignant peripheral nerve sheath tumour", "Malignant schwannoma", "Neurosarcoma" ; oboInOwl:id "HP:0100697" ; a owl:Class ; rdfs:comment "About half the cases are diagnosed in people with neurofibromatosis." ; rdfs:label "Neurofibrosarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0100698 obo:IAO_0000115 "A neurofibroma (benign peripheral nerve sheath tumor) localized in the subcutis (subcutaneous region)." ; dcterms:creator ; oboInOwl:creation_date "2011-03-29T12:03:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:425327002", "UMLS:C1827970" ; oboInOwl:id "HP:0100698" ; a owl:Class ; rdfs:label "Subcutaneous neurofibroma" ; rdfs:subClassOf obo:HP_0034761 . obo:HP_0100699 obo:IAO_0000115 "A scar refers to a lesion in which wound, burn, or sore has not healed completely and fibrous connective tissue has developed." ; dcterms:creator ; oboInOwl:creation_date "2011-03-29T06:39:56Z" ; oboInOwl:hasDbXref "MSH:D002921", "SNOMEDCT_US:48677004", "UMLS:C0008767" ; oboInOwl:hasExactSynonym "Scarring" ; oboInOwl:hasRelatedSynonym "Scar tissue" ; oboInOwl:id "HP:0100699" ; a owl:Class ; rdfs:label "Scarring" ; rdfs:subClassOf obo:HP_0003549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001850 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100700 obo:IAO_0000115 "An abnormality of the Arachnoid mater." ; dcterms:creator ; oboInOwl:creation_date "2011-03-31T12:43:27Z" ; oboInOwl:hasDbXref "UMLS:C4020955" ; oboInOwl:hasExactSynonym "Abnormality of the arachnoid mater", "Abnormality of the arachnoidea" ; oboInOwl:id "HP:0100700" ; a owl:Class ; rdfs:label "Abnormal arachnoid mater morphology" ; rdfs:subClassOf obo:HP_0010651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002362 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100701 obo:IAO_0000115 "An abnormality of the pia mater." ; dcterms:creator ; oboInOwl:creation_date "2011-03-31T12:44:41Z" ; oboInOwl:hasDbXref "UMLS:C4021994" ; oboInOwl:hasExactSynonym "Abnormality of the pia mater" ; oboInOwl:id "HP:0100701" ; a owl:Class ; rdfs:label "Abnormal pia mater" ; rdfs:subClassOf obo:HP_0010651 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002361 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100702 obo:IAO_0000115 "An extra-parenchymal and intra-arachnoidal collection of fluid with a composition similar to that of cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2011-03-31T12:46:59Z" ; oboInOwl:hasDbXref "MSH:D016080", "SNOMEDCT_US:33595009", "UMLS:C0078981" ; oboInOwl:hasExactSynonym "Fluid-filled sac located in membrane surrounding brain or spinal cord" ; oboInOwl:hasRelatedSynonym "Arachnoid cysts" ; oboInOwl:id "HP:0100702" ; a owl:Class ; rdfs:comment "Arachnoid cysts can be found on the brain, or on the spine. Intracranial arachnoid cysts usually occur adjacent to the arachnoidal cistern. Spinal arachnoid cysts may be extradural, intradural, or perineural." ; rdfs:label "Arachnoid cyst" ; rdfs:subClassOf obo:HP_0100700 . obo:HP_0100703 obo:IAO_0000115 "Pressing forward of the tongue in the mouth, a retained motoric habit from infantile swallowing patterns" ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2011-03-31T12:54:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:110343009", "SNOMEDCT_US:424583005", "UMLS:C1829460" ; oboInOwl:id "HP:0100703" ; a owl:Class ; rdfs:label "Tongue thrusting" ; rdfs:subClassOf obo:HP_5200017 . obo:HP_0100704 obo:IAO_0000115 "A form of loss of vision caused by damage to the visual cortex rather than a defect in the eye." ; dcterms:creator ; oboInOwl:creation_date "2011-03-31T01:03:21Z" ; oboInOwl:hasAlternativeId "HP:0000595" ; oboInOwl:hasDbXref "MSH:D019575", "SNOMEDCT_US:413924001", "SNOMEDCT_US:68574006", "UMLS:C0155320", "UMLS:C4048268" ; oboInOwl:hasExactSynonym "CVI", "Cortical blindness", "Cortical visual impairment", "Cortical/cerebral visual impairment" ; oboInOwl:id "HP:0100704" ; a owl:Class ; rdfs:comment "The term cortical/cerebral visual impairment (CVI) was coined to describe damage to visual pathways and structures occurring during early perinatal development. The term cortical visual impairment was originally proposed to describe visual dysfunction in pediatric populations of non-ocular cause, and its presumed association with damage to early visual cortical areas. However, as further characterization of this condition progressed, it became evident that CVI was often associated with damage to sites beyond early visual cortex including subcortical structures, white matter pathways, as well as higher-order associative processing areas of the cortex. Thus, the word cortical has been viewed as somewhat of a misnomer, and there has been the suggestion that the term cerebral would be a more encompassing and appropriate term. Although there is still a debate in the community about the most appropriate nomenclature, the HPO will regard these terms as synonymous. It is recommended that more specific terms be used as appropriate for annotation." ; rdfs:label "Cerebral visual impairment" ; rdfs:subClassOf obo:HP_0000505 . obo:HP_0100705 obo:IAO_0000115 "An abnormality of the glia cell." ; dcterms:creator ; oboInOwl:creation_date "2011-04-03T02:33:49Z" ; oboInOwl:hasDbXref "UMLS:C4021993" ; oboInOwl:hasExactSynonym "Abnormality of the glial cells" ; oboInOwl:id "HP:0100705" ; a owl:Class ; rdfs:comment "Glia are nonneuronal cells of the nervous system that provide physical support, respond to injury, regulate the composition of the extracellular milieu, guide neuronal migration during development, and exchange metabolites with neurons." ; rdfs:label "Abnormal glial cell morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000125 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100706 obo:IAO_0000115 "One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers." ; dcterms:creator ; oboInOwl:creation_date "2011-04-03T02:34:15Z" ; oboInOwl:hasDbXref "UMLS:C4021992" ; oboInOwl:hasExactSynonym "Abnormality of the oligodendroglia" ; oboInOwl:id "HP:0100706" ; a owl:Class ; rdfs:label "Abnormal oligodendroglia morphology" ; rdfs:subClassOf obo:HP_0100705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100707 obo:IAO_0000115 "An abnormality of astrocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-04-03T02:36:46Z" ; oboInOwl:hasDbXref "UMLS:C4021991" ; oboInOwl:hasExactSynonym "Abnormality of the astrocytes" ; oboInOwl:id "HP:0100707" ; a owl:Class ; rdfs:comment "Astrocytes represent a class of large neuroglial (macroglial) cells in the central nervous system." ; rdfs:label "Abnormal astrocyte morphology" ; rdfs:subClassOf obo:HP_0100705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000127 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100708 obo:IAO_0000115 "An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells." ; dcterms:creator ; oboInOwl:creation_date "2011-04-03T02:37:09Z" ; oboInOwl:hasDbXref "UMLS:C4021990" ; oboInOwl:hasExactSynonym "Abnormality of the microglia" ; oboInOwl:id "HP:0100708" ; a owl:Class ; rdfs:comment "Microglial cells represent a central nervous system macrophage found in the parenchyma of the central nervous system." ; rdfs:label "Abnormal microglia morphology" ; rdfs:subClassOf obo:HP_0100705 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:CL_0000129 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100709 dcterms:creator ; oboInOwl:creation_date "2011-04-03T02:39:50Z" ; oboInOwl:hasDbXref "UMLS:C4021852" ; oboInOwl:id "HP:0100709" ; a owl:Class ; rdfs:label "Reduction of oligodendroglia" ; rdfs:subClassOf obo:HP_0100706 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000128 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100710 obo:IAO_0000115 "Acting on the spur of the moment in response to immediate stimuli; acting on a momentary basis without a plan or consideration of outcomes; difficulty establishing or following plans; a sense of urgency and self-harming behavior under emotional distress." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:creation_date "2011-04-07T05:36:16Z" ; oboInOwl:hasDbXref "MSH:D007175", "UMLS:C0021125" ; oboInOwl:hasExactSynonym "Impulsive", "Impulsivity" ; oboInOwl:id "HP:0100710" ; a owl:Class ; rdfs:label "Impulsivity" ; rdfs:subClassOf obo:HP_0000734 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100711 obo:IAO_0000115 "An abnormality of the thoracic vertebral column." ; dcterms:creator ; oboInOwl:creation_date "2011-05-05T09:37:17Z" ; oboInOwl:hasDbXref "UMLS:C4021989" ; oboInOwl:hasExactSynonym "Abnormality of the thoracic spine" ; oboInOwl:id "HP:0100711" ; a owl:Class ; rdfs:label "Abnormal thoracic spine morphology" ; rdfs:subClassOf obo:HP_0000765, obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006073 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100712 obo:IAO_0000115 "Any structural abnormality of the lumbar vertebral column." ; dcterms:creator ; oboInOwl:creation_date "2011-05-05T09:37:33Z" ; oboInOwl:hasDbXref "UMLS:C4021988" ; oboInOwl:hasExactSynonym "Abnormality of the lumbar spine" ; oboInOwl:id "HP:0100712" ; a owl:Class ; rdfs:label "Abnormal lumbar spine morphology" ; rdfs:subClassOf obo:HP_0000925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006074 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100716 obo:IAO_0000115 "Aggression towards oneself." ; dcterms:creator ; oboInOwl:creation_date "2011-05-16T06:47:54Z" ; oboInOwl:hasDbXref "MSH:D016728", "SNOMEDCT_US:248062006", "UMLS:C0085271" ; oboInOwl:hasExactSynonym "Autoagression", "Self injury", "Self-harm", "Self-injurious behavior", "Self-injurious behaviour" ; oboInOwl:hasRelatedSynonym "Self-injurious behaviors", "Self-injurious behaviours" ; oboInOwl:id "HP:0100716" ; a owl:Class ; rdfs:label "Self-injurious behavior" ; rdfs:subClassOf obo:HP_0006919 . obo:HP_0100717 obo:IAO_0000115 "Any structural anomaly of the cementum, which is the mineralized connective tissue covering the dental root. The cementum allows anchoring of the fibers of the periodontal ligament. Cementum is secreted by cementoblasts, which may be, later on, embedded in the cementum. Cementum can be acellular (along the two third coronal portion of the root) and cellular (in the apical and interradicular part of the root)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T01:33:28Z" ; oboInOwl:hasDbXref "UMLS:C4021987" ; oboInOwl:hasExactSynonym "Abnormality of the cementum" ; oboInOwl:id "HP:0100717" ; a owl:Class ; rdfs:label "Abnormal cementum morphology" ; rdfs:subClassOf obo:HP_0011061, obo:HP_3000050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001753 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100718 dcterms:creator ; oboInOwl:creation_date "2011-06-06T01:49:29Z" ; oboInOwl:hasDbXref "MSH:D014597", "SNOMEDCT_US:34430009", "UMLS:C0042143" ; oboInOwl:id "HP:0100718" ; a owl:Class ; rdfs:label "Uterine rupture" ; rdfs:subClassOf obo:HP_0031105 . obo:HP_0100719 obo:IAO_0000115 "A sectoral indentation of the crystalline lens, usually due to zonular weakness or absence." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T02:16:53Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:204134008", "UMLS:C0344516" ; oboInOwl:id "HP:0100719" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Lens coloboma" ; rdfs:subClassOf obo:HP_0000589, obo:HP_0008063 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100720 dcterms:creator ; oboInOwl:creation_date "2011-06-06T02:17:54Z" ; oboInOwl:hasDbXref "UMLS:C4021986" ; oboInOwl:hasExactSynonym "Underdeveloped ear cartilage" ; oboInOwl:id "HP:0100720" ; a owl:Class ; rdfs:label "Hypoplasia of the ear cartilage" ; rdfs:subClassOf obo:HP_0008772 . obo:HP_0100721 obo:IAO_0000115 "Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T02:26:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:52324001", "UMLS:C0520743" ; oboInOwl:hasExactSynonym "Swollen lymph nodes in center of chest", "Swollen lymph nodes in centre of chest" ; oboInOwl:id "HP:0100721" ; a owl:Class ; rdfs:label "Mediastinal lymphadenopathy" ; rdfs:subClassOf obo:HP_0002716, obo:HP_0045026 . obo:HP_0100723 dcterms:creator ; oboInOwl:creation_date "2011-06-06T02:49:58Z" ; oboInOwl:hasDbXref "MSH:D046152", "SNOMEDCT_US:128755003", "SNOMEDCT_US:420120006", "UMLS:C0238198" ; oboInOwl:hasExactSynonym "GI stroma tumor", "GI stroma tumour", "GIST", "Gastrointestinal stroma tumour", "Gastrointestinal stromal tumor", "Gastrointestinal stromal tumour" ; oboInOwl:hasRelatedSynonym "Gastrointestinal stromal tumors", "Gastrointestinal stromal tumours" ; oboInOwl:id "HP:0100723" ; a owl:Class ; rdfs:label "Gastrointestinal stroma tumor" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0100724 obo:IAO_0000115 "An abnormality of coagulation associated with an increased risk of thrombosis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:04:38Z" ; oboInOwl:hasDbXref "MSH:D019851", "SNOMEDCT_US:234467004", "SNOMEDCT_US:76612001", "UMLS:C0398623" ; oboInOwl:hasExactSynonym "Blood hyperviscosity", "Thrombophilia" ; oboInOwl:id "HP:0100724" ; a owl:Class ; rdfs:label "Hypercoagulability" ; rdfs:subClassOf obo:HP_0001928 . obo:HP_0100725 obo:IAO_0000115 "Thickening and hardening of the epidermis seen with exaggeration of normal skin lines." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:18:53Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:19940005", "SNOMEDCT_US:402237006", "UMLS:C0023653" ; oboInOwl:id "HP:0100725" ; a owl:Class ; rdfs:label "Lichenification" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0100726 obo:IAO_0000115 "A systemic disease which can present with cutaneous lesions with or without internal involvement. Tumors are caused by Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:33:09Z" ; oboInOwl:hasDbXref "MSH:D012514", "SNOMEDCT_US:109385007", "SNOMEDCT_US:49937004", "UMLS:C0036220" ; oboInOwl:id "HP:0100726" ; a owl:Class ; rdfs:label "Kaposi's sarcoma" ; rdfs:subClassOf obo:HP_0008069 . obo:HP_0100727 obo:IAO_0000115 "An excessive number of histiocytes (tissue macrophages)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:43:05Z" ; oboInOwl:hasDbXref "MSH:D015614", "SNOMEDCT_US:60657004", "SNOMEDCT_US:65396000", "UMLS:C0019618" ; oboInOwl:id "HP:0100727" ; a owl:Class ; rdfs:label "Histiocytosis" ; rdfs:subClassOf obo:HP_0004311 . obo:HP_0100728 dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:46:36Z" ; oboInOwl:hasDbXref "NCIT:C3708", "UMLS:C4021985" ; oboInOwl:id "HP:0100728" ; a owl:Class ; rdfs:label "Germ cell neoplasia" ; rdfs:subClassOf obo:HP_0010785 . obo:HP_0100729 dcterms:creator ; oboInOwl:creation_date "2011-06-06T04:50:47Z" ; oboInOwl:hasDbXref "UMLS:C2748652" ; oboInOwl:hasExactSynonym "Big face", "Large face", "Large facies" ; oboInOwl:id "HP:0100729" ; a owl:Class ; rdfs:label "Large face" ; rdfs:subClassOf obo:HP_0001999 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100730 obo:IAO_0000115 "A rare congenital cystic lesion of the lungs in the mediastinum." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:01:27Z" ; oboInOwl:hasDbXref "MSH:D001994", "SNOMEDCT_US:268194008", "SNOMEDCT_US:9550003", "UMLS:C0006281" ; oboInOwl:id "HP:0100730" ; a owl:Class ; rdfs:comment "Bronchogenic cysts (BCs) are congenital lesions thought to result from abnormal budding of the embryonic foregut. The most frequent symptoms are pain, cough, fever, respiratory distress, or dyspnea. Intrapulmonary bronchogenic cysts are usually sharply defined, solitary, non-calcified, round, or oval opacities confined to a single lobe. These can present as a homogeneous water density, an air- filled cyst, or with an air-fluid level. The cyst can rupture into the trachea, pericardial cavity, or pleural cavity. Infection of the cyst may lead to surrounding acinar shadow. An air-filled cyst or one with an air-fluid level may be present if a complicating tracheo-bronchial connection develops." ; rdfs:label "Bronchogenic cyst" ; rdfs:subClassOf obo:HP_0032445 . obo:HP_0100731 obo:IAO_0000115 "A horizontal cleft of the face, varying from slight widening of the mouth, to a cleft extending to the ear." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:03:42Z" ; oboInOwl:hasDbXref "UMLS:C4020954" ; oboInOwl:hasExactSynonym "Lateral facial cleft" ; oboInOwl:id "HP:0100731" ; a owl:Class ; rdfs:comment "Usually, these clefts are unilateral and do not extend beyond the anterior border of the masseter. Transverse clefts are thought to develop either due to failure of the maxillary and mandibular processes to fuse or a disruption in the processes after fusing." ; rdfs:label "Transverse facial cleft" ; rdfs:subClassOf obo:HP_0002006, obo:HP_0011338 . obo:HP_0100732 dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:06:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:25942009", "UMLS:C0267952" ; oboInOwl:id "HP:0100732" ; a owl:Class ; rdfs:label "Pancreatic fibrosis" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0100733 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the parathyroid gland." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:09:38Z" ; oboInOwl:hasDbXref "MSH:D010282", "NCIT:C3262", "SNOMEDCT_US:127020005", "UMLS:C0030521" ; oboInOwl:hasExactSynonym "Parathyroid neoplasia" ; oboInOwl:id "HP:0100733" ; a owl:Class ; rdfs:label "Neoplasm of the parathyroid gland" ; rdfs:subClassOf obo:HP_0011766, obo:HP_0100568 . obo:HP_0100734 obo:IAO_0000115 "An anomaly of one or more epiphyses of one or more vertebrae." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:13:08Z" ; oboInOwl:hasDbXref "UMLS:C4020953" ; oboInOwl:hasExactSynonym "Abnormal shape of the end part of the vertebra bone", "Abnormality of the vertebral epiphyses" ; oboInOwl:id "HP:0100734" ; a owl:Class ; rdfs:label "Abnormality of vertebral epiphysis morphology" ; rdfs:subClassOf obo:HP_0003468, obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100735 dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:38:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:706882009", "UMLS:C0020546" ; oboInOwl:id "HP:0100735" ; a owl:Class ; rdfs:label "Hypertensive crisis" ; rdfs:subClassOf obo:HP_0000822 . obo:HP_0100736 obo:IAO_0000115 "An abnormality of the soft palate." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:41:48Z" ; oboInOwl:hasDbXref "UMLS:C4021984" ; oboInOwl:hasExactSynonym "Abnormality of the muscular palate", "Abnormality of the soft palate", "Abnormality of the velum", "Abnormality of the velum palatinum" ; oboInOwl:id "HP:0100736" ; a owl:Class ; rdfs:label "Abnormal soft palate morphology" ; rdfs:subClassOf obo:HP_0000174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001733 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100737 dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:42:10Z" ; oboInOwl:hasBroadSynonym "Abnormality of the secondary palate" ; oboInOwl:hasDbXref "UMLS:C4021983" ; oboInOwl:hasExactSynonym "Abnormality of the hard palate" ; oboInOwl:id "HP:0100737" ; a owl:Class ; rdfs:label "Abnormal hard palate morphology" ; rdfs:subClassOf obo:HP_0000174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003216 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100738 obo:IAO_0000115 "Abnormal eating habit with excessive or insufficient consumption of food or any other abnormal pattern of food consumption." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:54:51Z" ; oboInOwl:hasDbXref "UMLS:C4021982" ; oboInOwl:hasExactSynonym "Abnormal eating behavior", "Abnormal eating behaviour" ; oboInOwl:id "HP:0100738" ; a owl:Class ; rdfs:comment "Note that this HPO term refers to an abnormal eating habit but does not directly refer to an eating disorder, which is a psychological disorder that is characterized by one or more abnormal eating behaviors." ; rdfs:label "Abnormal eating behavior" ; rdfs:subClassOf obo:HP_0040202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042755 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100739 obo:IAO_0000115 "A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T05:55:43Z" ; oboInOwl:hasDbXref "MSH:D002032", "SNOMEDCT_US:78004001", "UMLS:C0006370" ; oboInOwl:hasExactSynonym "Binge and purge" ; oboInOwl:id "HP:0100739" ; a owl:Class ; rdfs:label "Bulimia" ; rdfs:subClassOf obo:HP_0100738 . obo:HP_0100742 obo:IAO_0000115 "A benign or malignant neoplasm (tumor) originating in the vascular system." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:08:26Z" ; oboInOwl:hasDbXref "MSH:D009383", "MSH:D019043", "NCIT:C3262", "SNOMEDCT_US:115235003", "SNOMEDCT_US:126736007", "SNOMEDCT_US:699605009", "UMLS:C0027668", "UMLS:C0282607" ; oboInOwl:hasExactSynonym "Blood vessel tumor", "Blood vessel tumour" ; oboInOwl:id "HP:0100742" ; a owl:Class ; rdfs:label "Vascular neoplasm" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0011793 . obo:HP_0100743 dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:20:18Z" ; oboInOwl:hasDbXref "MSH:D012004", "NCIT:C3262", "SNOMEDCT_US:126847008", "UMLS:C0034885" ; oboInOwl:hasExactSynonym "Rectal tumor", "Rectal tumour" ; oboInOwl:id "HP:0100743" ; a owl:Class ; rdfs:label "Neoplasm of the rectum" ; rdfs:subClassOf obo:HP_0002034, obo:HP_0100834 . obo:HP_0100744 dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:24:45Z" ; oboInOwl:hasDbXref "UMLS:C4021981" ; oboInOwl:id "HP:0100744" ; a owl:Class ; rdfs:label "Abnormality of the humeroradial joint" ; rdfs:subClassOf obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011111 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100745 obo:IAO_0000115 "An anomaly of the joint between the trochlear notch of ulna and the trochlea of humerus, which is part of the elbow joint." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:25:05Z" ; oboInOwl:hasDbXref "UMLS:C4021980" ; oboInOwl:id "HP:0100745" ; a owl:Class ; rdfs:label "Abnormality of the humeroulnar joint" ; rdfs:subClassOf obo:HP_0009811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0011110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100746 obo:IAO_0000115 "A type of Macrodactyly affecting one or several fingers." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:29:55Z" ; oboInOwl:hasDbXref "MSH:C537720", "SNOMEDCT_US:297195000", "UMLS:C0574044" ; oboInOwl:hasExactSynonym "Macrodactyly of hands" ; oboInOwl:id "HP:0100746" ; a owl:Class ; rdfs:label "Macrodactyly of finger" ; rdfs:subClassOf obo:HP_0001167, obo:HP_0004099 . obo:HP_0100747 obo:IAO_0000115 "A type of Macrodactyly affecting one or several toes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:29:55Z" ; oboInOwl:hasDbXref "MSH:C537719", "UMLS:C2931596" ; oboInOwl:hasExactSynonym "Foot macrodactyly" ; oboInOwl:id "HP:0100747" ; a owl:Class ; rdfs:label "Macrodactyly of toe" ; rdfs:subClassOf obo:HP_0001780, obo:HP_0004099 . obo:HP_0100748 dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:31:20Z" ; oboInOwl:hasDbXref "UMLS:C4021979" ; oboInOwl:hasExactSynonym "Muscular oedema" ; oboInOwl:id "HP:0100748" ; a owl:Class ; rdfs:label "Muscular edema" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001450 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100749 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:36:48Z" ; oboInOwl:hasDbXref "MSH:D002637", "SNOMEDCT_US:29857009", "UMLS:C0008031" ; oboInOwl:hasExactSynonym "Chest pain", "Thoracic pain" ; oboInOwl:hasRelatedSynonym "Chest discomfort" ; oboInOwl:id "HP:0100749" ; a owl:Class ; rdfs:label "Chest pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0100750 obo:IAO_0000115 "Collapse of part of a lung associated with absence of inflation (air) of that part." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:38:53Z" ; oboInOwl:hasDbXref "MSH:D001261", "SNOMEDCT_US:46621007", "UMLS:C0004144" ; oboInOwl:hasExactSynonym "Partial or complete collapse of part or entire lung", "Pulmonary atelectasis" ; oboInOwl:id "HP:0100750" ; a owl:Class ; rdfs:label "Atelectasis" ; rdfs:subClassOf obo:HP_0031983 . obo:HP_0100751 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the esophagus." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:44:54Z" ; oboInOwl:hasDbXref "MSH:D004938", "NCIT:C3262", "SNOMEDCT_US:126817006", "UMLS:C0014859" ; oboInOwl:hasExactSynonym "Esophageal tumor", "Esophageal tumour" ; oboInOwl:id "HP:0100751" ; a owl:Class ; rdfs:label "Esophageal neoplasm" ; rdfs:subClassOf obo:HP_0002031, obo:HP_0007378, obo:HP_0012288 . obo:HP_0100752 obo:IAO_0000115 "Formation of abnormal lobules (small masses of tissue) in the liver." ; dcterms:creator ; oboInOwl:creation_date "2011-06-06T06:47:05Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:253811003", "UMLS:C0345286" ; oboInOwl:hasExactSynonym "Anomalous liver lobulation", "Hepatic anomalous lobulation", "Liver lobation abnormal" ; oboInOwl:id "HP:0100752" ; a owl:Class ; rdfs:label "Abnormal liver lobulation" ; rdfs:subClassOf obo:HP_0030146 . obo:HP_0100753 obo:IAO_0000115 "A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T09:53:08Z" ; oboInOwl:hasDbXref "MSH:D012559", "SNOMEDCT_US:191526005", "SNOMEDCT_US:58214004", "UMLS:C0036341" ; oboInOwl:id "HP:0100753" ; a owl:Class ; rdfs:comment "Positive symptoms, such as delusions and hallucinations (especially of voices), are common, and any Schneiderian first-rank symptoms are particularly indicative of the illness. Negative symptoms include social withdrawal, impairment of ego boundaries, and loss of energy and initiative. Schizophrenia is diagnosed only if symptoms persist for at least one month. The illness can spontaneously remit, run a course with infrequent or frequent relapses, or become chronic. The prognosis has improved with antipsychotic drugs and with vigorous psychological and social management and rehabilitation. The many causes include genetic factors, environmental stress, and various triggering factors." ; rdfs:label "Schizophrenia" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0100754 obo:IAO_0000115 "A state of abnormally elevated or irritable mood, arousal, and or energy levels." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T09:54:05Z" ; oboInOwl:hasDbXref "MSH:D001714", "SNOMEDCT_US:231494001", "UMLS:C0338831" ; oboInOwl:hasExactSynonym "Manic" ; oboInOwl:id "HP:0100754" ; a owl:Class ; rdfs:label "Mania" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0100755 dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:01:04Z" ; oboInOwl:hasDbXref "UMLS:C4021978" ; oboInOwl:hasExactSynonym "Abnormal spit", "Abnormality of salivation" ; oboInOwl:id "HP:0100755" ; a owl:Class ; rdfs:label "Abnormality of salivation" ; rdfs:subClassOf obo:HP_0031815 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0046541 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100757 obo:IAO_0000115 "A rare pediatric carcinoma of the pancreas." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:05:52Z" ; oboInOwl:hasDbXref "MSH:C537162", "SNOMEDCT_US:53618008", "UMLS:C0334489" ; oboInOwl:id "HP:0100757" ; a owl:Class ; rdfs:label "Pancreatoblastoma" ; rdfs:subClassOf obo:HP_0002894 . obo:HP_0100758 obo:IAO_0000115 "A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:19:11Z" ; oboInOwl:hasDbXref "MSH:D005734", "SNOMEDCT_US:36024000", "SNOMEDCT_US:372070002", "UMLS:C0017086" ; oboInOwl:hasExactSynonym "Death of body tissue due to lack of blood flow or infection" ; oboInOwl:id "HP:0100758" ; a owl:Class ; rdfs:comment "This may occur after an injury or infection, or in people suffering from any chronic health problem affecting blood circulation. The prime cause of gangrene is reduced blood supply to the affected tissues, which results in cell death. Diabetes and long-term smoking increase the risk of suffering from gangrene. There are different types of gangrene with different symptoms, such as dry gangrene, wet gangrene, gas gangrene, internal gangrene and necrotising fasciitis. Treatment options include debridement (or, in severe cases, amputation) of the affected body parts, antibiotics, vascular surgery, maggot therapy or hyperbaric oxygen therapy." ; rdfs:label "Gangrene" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0100759 obo:IAO_0000115 "Terminal broadening of the fingers (distal phalanges of the fingers)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:25:26Z" ; oboInOwl:hasDbXref "MEDDRA:10016680", "MSH:D010005", "SNOMEDCT_US:30760008", "UMLS:C0009080" ; oboInOwl:hasExactSynonym "Clubbed fingers", "Clubbing (hands)", "Clubbing of fingers", "Finger clubbing" ; oboInOwl:id "HP:0100759" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Clubbing of fingers" ; rdfs:subClassOf obo:HP_0001211, obo:HP_0001217 . obo:HP_0100760 obo:IAO_0000115 "Terminal broadening of the toes (distal phalanges of the toes)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:25:26Z" ; oboInOwl:hasDbXref "MSH:D003025", "SNOMEDCT_US:249808002", "SNOMEDCT_US:397932003", "SNOMEDCT_US:53148007", "UMLS:C0009081", "UMLS:C3887489" ; oboInOwl:hasRelatedSynonym "Clubbed toes" ; oboInOwl:id "HP:0100760" ; a owl:Class ; rdfs:label "Clubbing of toes" ; rdfs:subClassOf obo:HP_0001217, obo:HP_0010161 . obo:HP_0100761 dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:33:09Z" ; oboInOwl:hasDbXref "UMLS:C4021977" ; oboInOwl:id "HP:0100761" ; a owl:Class ; rdfs:label "Visceral angiomatosis" ; rdfs:subClassOf obo:HP_0007461 . obo:HP_0100762 obo:IAO_0000115 "Bleeding into the biliary tree." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:36:09Z" ; oboInOwl:hasDbXref "MSH:D006431", "SNOMEDCT_US:66556007", "UMLS:C0018994" ; oboInOwl:hasExactSynonym "Haemobilia" ; oboInOwl:id "HP:0100762" ; a owl:Class ; rdfs:label "Hemobilia" ; rdfs:subClassOf obo:HP_0012439 . obo:HP_0100763 obo:IAO_0000115 "An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:40:36Z" ; oboInOwl:hasAlternativeId "HP:0003012" ; oboInOwl:hasDbXref "MSH:D008206", "SNOMEDCT_US:111590001", "SNOMEDCT_US:234087005", "SNOMEDCT_US:3305006", "SNOMEDCT_US:362971004", "UMLS:C0024228", "UMLS:C4021976" ; oboInOwl:hasRelatedSynonym "Lymphatic disease" ; oboInOwl:id "HP:0100763" ; a owl:Class ; rdfs:label "Abnormality of the lymphatic system" ; rdfs:subClassOf obo:HP_0002597, obo:HP_0002715 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006558 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100764 obo:IAO_0000115 "Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:41:13Z" ; oboInOwl:hasDbXref "MSH:D008202", "NCIT:C8965", "SNOMEDCT_US:253057002", "SNOMEDCT_US:254836000", "SNOMEDCT_US:400178008", "SNOMEDCT_US:69044001", "UMLS:C0024221" ; oboInOwl:id "HP:0100764" ; a owl:Class ; rdfs:label "Lymphangioma" ; rdfs:subClassOf obo:HP_0100763 . obo:HP_0100765 obo:IAO_0000115 "An abnormality of the tonsils." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:43:35Z" ; oboInOwl:hasDbXref "UMLS:C4021975" ; oboInOwl:id "HP:0100765" ; a owl:Class ; rdfs:label "Abnormality of the tonsils" ; rdfs:subClassOf obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002372 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100766 obo:IAO_0000115 "A structural anomaly of the vessel that contains or conveys lymph fluid." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T10:44:54Z" ; oboInOwl:hasDbXref "UMLS:C4021974" ; oboInOwl:hasExactSynonym "Abnormality of the lymphatic vessels" ; oboInOwl:id "HP:0100766" ; a owl:Class ; rdfs:label "Abnormal lymphatic vessel morphology" ; rdfs:subClassOf obo:HP_0025015, obo:HP_0100763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100767 obo:IAO_0000115 "An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:03:03Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:169957005", "SNOMEDCT_US:33552005", "UMLS:C1306893" ; oboInOwl:hasExactSynonym "Abnormality of the placenta", "Placental issue" ; oboInOwl:id "HP:0100767" ; a owl:Class ; rdfs:comment "The placenta is a fetomaternal organ. The fetal portion of the placenta is the villous chorion and the maternal portion is the decidua basalis. The two portions are connected by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." ; rdfs:label "Abnormal placenta morphology" ; rdfs:subClassOf obo:HP_0001194 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001987 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100768 obo:IAO_0000115 "A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:05:40Z" ; oboInOwl:hasDbXref "MSH:D002822", "SNOMEDCT_US:188188009", "SNOMEDCT_US:44769000", "UMLS:C0008497" ; oboInOwl:id "HP:0100768" ; a owl:Class ; rdfs:label "Choriocarcinoma" ; rdfs:subClassOf obo:HP_0031502, obo:HP_0100767 . obo:HP_0100769 dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:45:59Z" ; oboInOwl:hasDbXref "MSH:D013585", "SNOMEDCT_US:416209007", "UMLS:C0039103" ; oboInOwl:id "HP:0100769" ; a owl:Class ; rdfs:label "Synovitis" ; rdfs:subClassOf obo:HP_0005262 . obo:HP_0100770 obo:IAO_0000115 "Excessively active peristalsis (wave of contraction of the tubular organs of the gastrointestinal tract) marked by excessive rapidity of the passage of food through the stomach and intestine." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:53:08Z" ; oboInOwl:hasBroadSynonym "Stomach churning" ; oboInOwl:hasDbXref "SNOMEDCT_US:271838002", "SNOMEDCT_US:80306002", "UMLS:C0232474", "UMLS:C0857071" ; oboInOwl:id "HP:0100770" ; a owl:Class ; rdfs:label "Hyperperistalsis" ; rdfs:subClassOf obo:HP_0030914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002304 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030432 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100771 obo:IAO_0000115 "Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T11:53:08Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77853002", "UMLS:C0232475", "UMLS:C4020700" ; oboInOwl:hasRelatedSynonym "Intestinal hypoperistalsis" ; oboInOwl:id "HP:0100771" ; a owl:Class ; rdfs:label "Hypoperistalsis" ; rdfs:subClassOf obo:HP_0030914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030432 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100773 dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:13:50Z" ; oboInOwl:hasDbXref "UMLS:C4021973" ; oboInOwl:hasExactSynonym "Cartilage destruction" ; oboInOwl:id "HP:0100773" ; a owl:Class ; rdfs:label "Cartilage destruction" ; rdfs:subClassOf obo:HP_0002763 . obo:HP_0100774 obo:IAO_0000115 "Excessive growth or abnormal thickening of bone tissue." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:17:19Z" ; oboInOwl:hasDbXref "MSH:D015576", "SNOMEDCT_US:13814009", "SNOMEDCT_US:203514008", "UMLS:C0020492" ; oboInOwl:hasExactSynonym "Bone Hypertrophy", "Bone overgrowth" ; oboInOwl:id "HP:0100774" ; a owl:Class ; rdfs:comment "Hyperostosis refers to a localized bone overgrowth process (as opposed to sclerosis, which refers to a generalized disturbance with increased bone density)." ; rdfs:label "Hyperostosis" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000584 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100775 obo:IAO_0000115 "A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:22:13Z" ; oboInOwl:hasDbXref "UMLS:C1851712" ; oboInOwl:id "HP:0100775" ; a owl:Class ; rdfs:comment "Dural ectasia is one of the major manifestations of Marfan syndrome. It may cause low back pain, headaches and neurological signs such as weakness and loss of bowel and bladder function, but in many patients it is asymptomatic. It is also a cause of posterior vertebral scalloping present in radiographs in patients who are diagnosed with Neurofibromatosis. Dural ectasia may also manifest in Ehlers-Danlos Syndrome, cauda equina syndrome and in ankylosing spondylitis." ; rdfs:label "Dural ectasia" ; rdfs:subClassOf obo:HP_0010303 . obo:HP_0100776 obo:IAO_0000115 "An increased susceptibility to pharyngitis as manifested by a history of recurrent pharyngitis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:28:27Z" ; oboInOwl:hasDbXref "UMLS:C0747556" ; oboInOwl:hasExactSynonym "Pharyngitis, recurrent", "Recurrent sore throat" ; oboInOwl:id "HP:0100776" ; a owl:Class ; rdfs:label "Recurrent pharyngitis" ; rdfs:subClassOf obo:HP_0002788, obo:HP_0025439 . obo:HP_0100777 obo:IAO_0000115 "An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:34:49Z" ; oboInOwl:hasDbXref "MSH:D005096", "SNOMEDCT_US:416189003", "SNOMEDCT_US:80400009", "UMLS:C1442903" ; oboInOwl:hasExactSynonym "Formation of new noncancerous bone on top of existing bone" ; oboInOwl:id "HP:0100777" ; a owl:Class ; rdfs:label "Exostoses" ; rdfs:subClassOf obo:HP_0010622 . obo:HP_0100778 obo:IAO_0000115 "Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:42:38Z" ; oboInOwl:hasDbXref "MSH:D003449", "SNOMEDCT_US:30911005", "UMLS:C0010403" ; oboInOwl:hasExactSynonym "Cryoprecipitable immune complexes" ; oboInOwl:id "HP:0100778" ; a owl:Class ; rdfs:label "Cryoglobulinemia" ; rdfs:subClassOf obo:HP_0005368 . obo:HP_0100779 obo:IAO_0000115 "A rare birth defect in women where the urethra and vagina both open into a common channel." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:45:10Z" ; oboInOwl:hasDbXref "UMLS:C4021972" ; oboInOwl:id "HP:0100779" ; a owl:Class ; rdfs:label "Urogenital sinus anomaly" ; rdfs:subClassOf obo:HP_0000142, obo:HP_0000795 . obo:HP_0100780 obo:IAO_0000115 "A hamartoma (disordered proliferation of mature tissues) of the conjunctiva." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:50:21Z" ; oboInOwl:hasDbXref "UMLS:C4021849" ; oboInOwl:id "HP:0100780" ; a owl:Class ; rdfs:label "Conjunctival hamartoma" ; rdfs:subClassOf obo:HP_0000502, obo:HP_0010568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_74 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100781 obo:IAO_0000115 "An anomaly of the sacroiliac joint, which connects the base of the spine (sacrum) to the ilium (a hip bone)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T05:52:24Z" ; oboInOwl:hasDbXref "UMLS:C0262621" ; oboInOwl:hasExactSynonym "Abnormality of the sacroiliac joint" ; oboInOwl:id "HP:0100781" ; a owl:Class ; rdfs:comment "The sacroiliac joint (SIJ) is a true diarthrodial joint: matching articular surfaces separated by a joint space containing synovial fluid and enveloped by a fibrous capsule. It does, however, have unique characteristics not typically found in other diarthrodial joints. The SIJ has fibrocartilage in addition to hyaline cartilage. There is discontinuity of the posterior capsule. Rather than being smooth, the articular surfaces have many ridges and depressions that minimize movement and enhance stability. Primary stability, however, is attributed to the many adjacent ligaments." ; rdfs:label "Abnormal sacroiliac joint morphology" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0002867, obo:HP_0005107 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001365 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100783 obo:IAO_0000115 "Failure to develop and congenital absence of the breast." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T06:02:34Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:111324004", "UMLS:C0266009" ; oboInOwl:hasExactSynonym "Absent breast", "Congenital absence of breast", "Mammary gland aplasia" ; oboInOwl:id "HP:0100783" ; a owl:Class ; rdfs:label "Breast aplasia" ; rdfs:subClassOf obo:HP_0010311 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000310 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100784 dcterms:creator ; oboInOwl:creation_date "2011-06-07T06:03:29Z" ; oboInOwl:hasDbXref "UMLS:C4021971" ; oboInOwl:id "HP:0100784" ; a owl:Class ; rdfs:label "Peripheral arteriovenous fistula" ; rdfs:subClassOf obo:HP_0004947 . obo:HP_0100785 obo:IAO_0000115 "Persistent difficulty initiating or maintaining sleep." ; dcterms:creator ; oboInOwl:creation_date "2011-06-07T06:14:22Z" ; oboInOwl:hasDbXref "MSH:D007319", "SNOMEDCT_US:193462001", "UMLS:C0917801" ; oboInOwl:hasExactSynonym "Difficulty staying or falling asleep" ; oboInOwl:hasNarrowSynonym "Fragmented sleep" ; oboInOwl:id "HP:0100785" ; a owl:Class ; rdfs:label "Insomnia" ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0100786 dcterms:creator ; oboInOwl:creation_date "2011-06-07T06:15:07Z" ; oboInOwl:hasDbXref "MSH:D006970", "SNOMEDCT_US:77692006", "UMLS:C0917799" ; oboInOwl:hasExactSynonym "Excessive sleepiness" ; oboInOwl:id "HP:0100786" ; a owl:Class ; rdfs:label "Hypersomnia" ; rdfs:subClassOf obo:HP_0002360 . obo:HP_0100787 dcterms:creator ; oboInOwl:creation_date "2011-06-07T06:29:49Z" ; oboInOwl:hasDbXref "MSH:D011471", "SNOMEDCT_US:126906006", "UMLS:C0033578" ; oboInOwl:id "HP:0100787" ; a owl:Class ; rdfs:label "Prostate neoplasm" ; rdfs:subClassOf obo:HP_0008775, obo:HP_0033019 . obo:HP_0100788 obo:IAO_0000115 "Lack of separation of the upper and lower lips." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T02:16:16Z" ; oboInOwl:hasDbXref "UMLS:C4021970" ; oboInOwl:hasExactSynonym "Adhesion of upper and lower lips", "Fused lips", "Fusion of upper and lower lips" ; oboInOwl:id "HP:0100788" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Fused lips" ; rdfs:subClassOf obo:HP_0000159 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100789 obo:IAO_0000115 "A bony protrusion present on the midline of the hard palate." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T02:28:48Z" ; oboInOwl:hasBroadSynonym "Maxillary torus" ; oboInOwl:hasDbXref "SNOMEDCT_US:244683008", "SNOMEDCT_US:46752004", "SNOMEDCT_US:697945009", "UMLS:C0266981", "UMLS:C0447996", "UMLS:C1840236" ; oboInOwl:hasExactSynonym "Palatal tori", "Palatal torus", "Palate exostoses" ; oboInOwl:hasRelatedSynonym "Prominent midpalatal ridge" ; oboInOwl:id "HP:0100789" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Torus palatinus" ; rdfs:subClassOf obo:HP_0100737 . obo:HP_0100790 dcterms:creator ; oboInOwl:creation_date "2011-06-08T02:33:37Z" ; oboInOwl:hasDbXref "MSH:D006547", "SNOMEDCT_US:414403008", "SNOMEDCT_US:52515009", "UMLS:C0019270" ; oboInOwl:hasRelatedSynonym "Hernias" ; oboInOwl:id "HP:0100790" ; a owl:Class ; rdfs:label "Hernia" ; rdfs:subClassOf obo:HP_0003549 . obo:HP_0100792 obo:IAO_0000115 "The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T03:22:24Z" ; oboInOwl:hasDbXref "MSH:D000051", "SNOMEDCT_US:43327007", "SNOMEDCT_US:441837004", "UMLS:C0000887", "UMLS:C0241128" ; oboInOwl:hasRelatedSynonym "Nikolsky's sign" ; oboInOwl:id "HP:0100792" ; a owl:Class ; rdfs:comment "Acantolysis results in a positive Nikolsky's sign in which slight rubbing of the skin results in exfoliation of the outermost layer." ; rdfs:label "Acantholysis" ; rdfs:subClassOf obo:HP_0011124 . obo:HP_0100795 obo:IAO_0000115 "The absence of the normal curvature of the vertebral column." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T03:52:57Z" ; oboInOwl:hasDbXref "UMLS:C4021969" ; oboInOwl:hasExactSynonym "Abnormally straight spine" ; oboInOwl:id "HP:0100795" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormally straight spine" ; rdfs:subClassOf obo:HP_0010674 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002180 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001130 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100796 obo:IAO_0000115 "Testicular inflammation." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T04:18:06Z" ; oboInOwl:hasDbXref "MSH:D009920", "SNOMEDCT_US:274718005", "UMLS:C0029191" ; oboInOwl:hasExactSynonym "Inflammation of testicles" ; oboInOwl:id "HP:0100796" ; a owl:Class ; rdfs:label "Orchitis" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0100797 obo:IAO_0000115 "An abnormality of the development of the toenails." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T04:23:37Z" ; oboInOwl:hasDbXref "UMLS:C3276623" ; oboInOwl:hasExactSynonym "Abnormal toenail development", "Dysplastic toenails" ; oboInOwl:id "HP:0100797" ; a owl:Class ; rdfs:label "Toenail dysplasia" ; rdfs:subClassOf obo:HP_0002164, obo:HP_0008388 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000640 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0009567 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100798 obo:IAO_0000115 "An abnormality of the development of the fingernails." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T04:23:53Z" ; oboInOwl:hasDbXref "UMLS:C4020952" ; oboInOwl:hasExactSynonym "Abnormal fingernail development", "Dysplastic fingernails" ; oboInOwl:id "HP:0100798" ; a owl:Class ; rdfs:comment "If possible, a more precise term should be chosen for annotation." ; rdfs:label "Fingernail dysplasia" ; rdfs:subClassOf obo:HP_0001231, obo:HP_0002164 . obo:HP_0100799 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the middle ear." ; dcterms:creator ; oboInOwl:creation_date "2011-06-08T04:25:43Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:127006003", "UMLS:C0345617" ; oboInOwl:hasExactSynonym "Middle ear tumor", "Middle ear tumour", "Neoplasia of the middle ear" ; oboInOwl:id "HP:0100799" ; a owl:Class ; rdfs:label "Neoplasm of the middle ear" ; rdfs:subClassOf obo:HP_0000370, obo:HP_0012780 . obo:HP_0100800 obo:IAO_0000115 "A congenital underdevelopment (aplasia or hypoplasia) of the pancreas." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T11:45:58Z" ; oboInOwl:hasDbXref "UMLS:C4021968" ; oboInOwl:hasExactSynonym "Absent/small pancreas", "Absent/underdeveloped pancreas" ; oboInOwl:id "HP:0100800" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the pancreas" ; rdfs:subClassOf obo:HP_0012094 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100801 obo:IAO_0000115 "Aplasia of the pancreas." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T11:46:59Z" ; oboInOwl:hasDbXref "UMLS:C4021967" ; oboInOwl:hasExactSynonym "Absent pancreas" ; oboInOwl:id "HP:0100801" ; a owl:Class ; rdfs:label "Pancreatic aplasia" ; rdfs:subClassOf obo:HP_0100800 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100802 obo:IAO_0000115 "Abnormal anatomical location of the stomach. This feature may be due to intestinal malrotation." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T11:52:49Z" ; oboInOwl:hasDbXref "UMLS:C1402983" ; oboInOwl:hasExactSynonym "Abnormal stomach location", "Gastric ectopia", "Gastric malposition" ; oboInOwl:id "HP:0100802" ; a owl:Class ; rdfs:label "Malposition of the stomach" ; rdfs:subClassOf obo:HP_0002577 . obo:HP_0100803 obo:IAO_0000115 "An abnormality of the region around the nails of the fingers or toes." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T11:59:15Z" ; oboInOwl:hasDbXref "UMLS:C4021966" ; oboInOwl:id "HP:0100803" ; a owl:Class ; rdfs:label "Abnormality of the periungual region" ; rdfs:subClassOf obo:HP_0001597, obo:HP_0011356 . obo:HP_0100804 obo:IAO_0000115 "Flesh-colored papule in or around the nail bed. Ungual fibromas may be periungual (arising under the proximal nail fold) or subungual (originating under the nail plate)." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T11:59:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:264561009", "UMLS:C0442880" ; oboInOwl:hasExactSynonym "Koenen tumor", "Koenen tumour", "Koenen's tumor", "Koenen's tumour", "Parungual fibromas", "Periungual fibroma" ; oboInOwl:id "HP:0100804" ; a owl:Class ; rdfs:comment "Ungual fibromas are characteristic of tuberous sclerosis." ; rdfs:label "Ungual fibroma" ; rdfs:subClassOf obo:HP_0010614, obo:HP_0100803, obo:HP_0100826 . obo:HP_0100805 oboInOwl:id "HP:0100805" ; a owl:Class ; rdfs:label "obsolete Precocious menopause" ; owl:deprecated true . obo:HP_0100806 obo:IAO_0000115 "Systemic inflammatory response to infection." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:05:51Z" ; oboInOwl:hasDbXref "MSH:D018805", "UMLS:C0036690" ; oboInOwl:hasExactSynonym "Infection in blood stream" ; oboInOwl:id "HP:0100806" ; a owl:Class ; rdfs:label "Sepsis" ; rdfs:subClassOf obo:HP_0010978 . obo:HP_0100807 obo:IAO_0000115 "The middle finger is more than 2 SD above the mean for newborns 27 to 41 weeks EGA or above the 97th centile for children from birth to 16 years of age AND the five digits retain their normal length proportions relative to each other (i.e., it is not the case that the middle finger is the only lengthened digit), or, Fingers that appear disproportionately long compared to the palm of the hand." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:13:15Z" ; oboInOwl:hasAlternativeId "HP:0006010" ; oboInOwl:hasDbXref "UMLS:C1858091" ; oboInOwl:hasExactSynonym "Long fingers" ; oboInOwl:id "HP:0100807" ; a owl:Class ; rdfs:label "Long fingers" ; rdfs:subClassOf obo:HP_0001167 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002389 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100808 obo:IAO_0000115 "An outpouching of the gastric wall." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:43:31Z" ; oboInOwl:hasDbXref "MSH:D013273", "SNOMEDCT_US:75198005", "UMLS:C0038355" ; oboInOwl:hasExactSynonym "Stomach diverticulum" ; oboInOwl:id "HP:0100808" ; a owl:Class ; rdfs:comment "Gastric diverticulum may be asymptomatic or may present with a vague sensation of fullness or discomfort in the upper abdomen, or with acute upper gastrointestinal bleed or perforation." ; rdfs:label "Gastric diverticulum" ; rdfs:subClassOf obo:HP_0002577 . obo:HP_0100809 obo:IAO_0000115 "Pain or discomfort of the scalp elicited by palpation." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:46:12Z" ; oboInOwl:hasBroadSynonym "Scalp pain" ; oboInOwl:hasDbXref "MEDDRA:10039521", "SNOMEDCT_US:75851004", "UMLS:C0151206", "UMLS:C0240940", "UMLS:C4073183" ; oboInOwl:hasExactSynonym "Scalp hypersensitivity", "Scalp tenderness" ; oboInOwl:hasNarrowSynonym "Allodynia of scalp" ; oboInOwl:id "HP:0100809" ; a owl:Class ; rdfs:label "Scalp tenderness" ; rdfs:subClassOf obo:HP_0001965 . obo:HP_0100810 dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:51:46Z" ; oboInOwl:hasBroadSynonym "Pointed ear" ; oboInOwl:hasDbXref "UMLS:C4020951" ; oboInOwl:hasExactSynonym "Elfin ear", "Spock ear", "Spock's ear", "Vulcan ear" ; oboInOwl:id "HP:0100810" ; a owl:Class ; rdfs:label "Pointed helix" ; rdfs:subClassOf obo:HP_0011039 . obo:HP_0100811 obo:IAO_0000115 "Congenital absence or underdevelopment of the colon." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T01:54:57Z" ; oboInOwl:hasDbXref "UMLS:C4021964" ; oboInOwl:hasExactSynonym "Absent/small colon", "Absent/underdeveloped colon" ; oboInOwl:id "HP:0100811" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the colon" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0005245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100812 obo:IAO_0000115 "Noticeably unpleasant odors exhaled in breathing." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T02:00:42Z" ; oboInOwl:hasDbXref "MEDDRA:10006326", "MSH:D006209", "SNOMEDCT_US:79879001", "UMLS:C0018520" ; oboInOwl:hasExactSynonym "Bad breath", "Foetor ex ore" ; oboInOwl:id "HP:0100812" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Halitosis" ; rdfs:subClassOf obo:HP_0025142, obo:HP_0031815 . obo:HP_0100813 obo:IAO_0000115 "Testicular torsion is when the spermatic cord to a testicle twists, cutting off the blood supply. The most common symptom is acute testicular pain." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T02:03:12Z" ; oboInOwl:hasDbXref "MSH:D013086", "SNOMEDCT_US:49198006", "SNOMEDCT_US:81996005", "UMLS:C0037856" ; oboInOwl:hasExactSynonym "Spermatic cord torsion" ; oboInOwl:id "HP:0100813" ; a owl:Class ; rdfs:comment "Many of the symptoms of testicular torsion are similar to the infection epididymitis." ; rdfs:label "Testicular torsion" ; rdfs:subClassOf obo:HP_0000035 . obo:HP_0100814 dcterms:creator ; oboInOwl:creation_date "2011-06-09T02:15:28Z" ; oboInOwl:hasDbXref "MSH:D049328", "SNOMEDCT_US:40467008", "UMLS:C0265985", "UMLS:C4020699" ; oboInOwl:hasExactSynonym "Mongolian spot" ; oboInOwl:hasRelatedSynonym "Congenital dermal melanocytosis" ; oboInOwl:id "HP:0100814" ; a owl:Class ; rdfs:label "Blue nevus" ; rdfs:subClassOf obo:HP_0003764 . obo:HP_0100816 dcterms:creator ; oboInOwl:creation_date "2011-06-09T02:18:39Z" ; oboInOwl:hasDbXref "UMLS:C4021963" ; oboInOwl:hasExactSynonym "Darkening of skin of the lips", "Hyperpigmentation of lip vermillion", "Increased pigmentation on the lips" ; oboInOwl:id "HP:0100816" ; a owl:Class ; rdfs:label "Lip hyperpigmentation" ; rdfs:subClassOf obo:HP_0007400, obo:HP_0032453 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100817 obo:IAO_0000115 "The presence of hypertension related to stenosis of the renal artery." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T04:48:35Z" ; oboInOwl:hasAlternativeId "HP:0008741" ; oboInOwl:hasDbXref "MSH:D006978", "SNOMEDCT_US:123799005", "UMLS:C0020545" ; oboInOwl:hasExactSynonym "Hypertension due to renal artery hyperplasia" ; oboInOwl:id "HP:0100817" ; a owl:Class ; rdfs:comment "Renal artery stenosis can lead to hypertension and chronic kidney disease (due to chronic renal ischemia). The hypertension is caused by activation of the renin-angiotensin-aldosterone system." ; rdfs:label "Renovascular hypertension" ; rdfs:subClassOf obo:HP_0000822, obo:HP_0012211 . obo:HP_0100818 obo:IAO_0000115 "Increased inferior to superior extent of the thorax." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T04:51:15Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:298710001", "UMLS:C0575484" ; oboInOwl:hasExactSynonym "Long rib cage" ; oboInOwl:id "HP:0100818" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Long thorax" ; rdfs:subClassOf obo:HP_0100625 . obo:HP_0100819 obo:IAO_0000115 "An abnormal connection between the gut and another hollow organ, such as the bladder, urethra, vagina, or other regions of the gastrointestinal tract." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T04:57:15Z" ; oboInOwl:hasDbXref "MEDDRA:10022647", "MSH:D007412", "SNOMEDCT_US:38851006", "UMLS:C0021833" ; oboInOwl:id "HP:0100819" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Intestinal fistula" ; rdfs:subClassOf obo:HP_0002242 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_70 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100820 obo:IAO_0000115 "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T04:59:55Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:197679002", "UMLS:C0268731" ; oboInOwl:hasExactSynonym "Diseased glomeruli" ; oboInOwl:id "HP:0100820" ; a owl:Class ; rdfs:label "Glomerulopathy" ; rdfs:subClassOf obo:HP_0000095 . obo:HP_0100821 obo:IAO_0000115 "The prolapse of the female urethra into the vagina." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:06:51Z" ; oboInOwl:hasDbXref "ICD-9:618.03", "SNOMEDCT_US:12068006", "UMLS:C0238502" ; oboInOwl:id "HP:0100821" ; a owl:Class ; rdfs:label "Urethrocele" ; rdfs:subClassOf obo:HP_0000795, obo:HP_0100672 . obo:HP_0100822 obo:IAO_0000115 "A Rectocele results from a tear in the rectovaginal septum (which is normally a tough, fibrous, sheet-like divider between the rectum and vagina). Rectal tissue bulges through this tear and into the vagina as a hernia. There are two main causes of this tear: childbirth, and hysterectomy." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:07:41Z" ; oboInOwl:hasDbXref "ICD-9:618.04", "MSH:D020047", "SNOMEDCT_US:447072005", "SNOMEDCT_US:62730001", "UMLS:C0149771" ; oboInOwl:id "HP:0100822" ; a owl:Class ; rdfs:label "Rectocele" ; rdfs:subClassOf obo:HP_0002035, obo:HP_0100672 . obo:HP_0100823 dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:11:49Z" ; oboInOwl:hasDbXref "UMLS:C4021962" ; oboInOwl:id "HP:0100823" ; a owl:Class ; rdfs:label "Genital hernia" ; rdfs:subClassOf obo:HP_0100790 . obo:HP_0100825 obo:IAO_0000115 "Inflammation of the lip." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:18:41Z" ; oboInOwl:hasDbXref "MSH:D002613", "SNOMEDCT_US:7847004", "UMLS:C0007971", "UMLS:C4280288" ; oboInOwl:hasExactSynonym "Inflammation of the lips" ; oboInOwl:hasRelatedSynonym "Red and sore lips" ; oboInOwl:id "HP:0100825" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "It is associated with many conditions, including megaloblastic anemia from vitamin B12 deficiency, iron deficiency anemia (which in severe cases can lead to Plummer-Vinson syndrome) and oral candidiasis. It can also be a symptom of allergies, such as allergy to Balsam of Peru. Cheilitis can also be caused by taking the (retinoid) drug Isotretinoin. It may also be a pre-malignant lesion for squamous cell carcinoma." ; rdfs:label "Cheilitis" ; rdfs:subClassOf obo:HP_0000159 . obo:HP_0100826 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the nail." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:31:21Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4021961" ; oboInOwl:hasExactSynonym "Nail tumor", "Nail tumour" ; oboInOwl:id "HP:0100826" ; a owl:Class ; rdfs:label "Neoplasm of the nail" ; rdfs:subClassOf obo:HP_0001597, obo:HP_0011793 . obo:HP_0100827 obo:IAO_0000115 "Increase in the number or proportion of lymphocytes in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:32:57Z" ; oboInOwl:hasAlternativeId "HP:0012141" ; oboInOwl:hasDbXref "MSH:D008218", "SNOMEDCT_US:67023009", "UMLS:C0024282" ; oboInOwl:hasExactSynonym "High lymphocyte count" ; oboInOwl:id "HP:0100827" ; a owl:Class ; rdfs:label "Lymphocytosis" ; rdfs:subClassOf obo:HP_0001974, obo:HP_0040088 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000542 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100828 obo:IAO_0000115 "An abnormal increase in the total number of T cells detected in the blood." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:34:46Z" ; oboInOwl:hasDbXref "UMLS:C4021960" ; oboInOwl:hasExactSynonym "Increase in T cell count", "Increase in T cell number" ; oboInOwl:id "HP:0100828" ; a owl:Class ; rdfs:label "Increased T cell count" ; rdfs:subClassOf obo:HP_0011839, obo:HP_0100827 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100829 obo:IAO_0000115 "Spontaneous flow of milk from the breast, unassociated with childbirth or nursing." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:39:15Z" ; oboInOwl:hasDbXref "MSH:D005687", "UMLS:C3665358" ; oboInOwl:hasExactSynonym "Galactorrhoea", "Spontaneous milk flow from breast" ; oboInOwl:id "HP:0100829" ; a owl:Class ; rdfs:label "Galactorrhea" ; rdfs:subClassOf obo:HP_0031094 . obo:HP_0100830 dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:41:29Z" ; oboInOwl:hasDbXref "UMLS:C4021959" ; oboInOwl:hasExactSynonym "Round ear" ; oboInOwl:id "HP:0100830" ; a owl:Class ; rdfs:label "Round ear" ; rdfs:subClassOf obo:HP_0000377 . obo:HP_0100831 obo:IAO_0000115 "Vitamin K is a fat-soluble vitamin with a role in promoting the coagulation cascade." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:46:50Z" ; oboInOwl:hasDbXref "UMLS:C4021958" ; oboInOwl:hasExactSynonym "Abnormality of vitamin K metabolism" ; oboInOwl:id "HP:0100831" ; a owl:Class ; rdfs:label "Abnormality of vitamin K metabolism" ; rdfs:subClassOf obo:HP_0100508 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042373 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100832 obo:IAO_0000115 "Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T05:58:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:15013002", "SNOMEDCT_US:162278001", "SNOMEDCT_US:420999000", "UMLS:C0016242", "UMLS:C1720491" ; oboInOwl:hasExactSynonym "Eye floaters", "Flitting flies", "Mouches volantes", "Myodeopsia", "Myodesopsia", "Spots in front of eyes", "Vitreous condensations", "Vitreous debris", "Vitreous opacities", "Vitreous veils" ; oboInOwl:id "HP:0100832" ; a owl:Class ; rdfs:comment "Vitreous floaters are described as vitreous condensations (or vitreous debris or vitreous opacities) as a finding upon ophthalmological examination. Floaters can take many forms from little dots, circles, lines, to clouds or cobwebs. The floaters are created by a shadow of the floating vitreal debris that is projected onto the retina, which is described as a veil." ; rdfs:label "Vitreous floaters" ; rdfs:subClassOf obo:HP_0000504, obo:HP_0004327 . obo:HP_0100833 obo:IAO_0000115 "The presence of a neoplasm of the small intestine." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:03:02Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:126832004", "UMLS:C0345832" ; oboInOwl:hasExactSynonym "Small intestine tumor", "Small intestine tumour" ; oboInOwl:id "HP:0100833" ; a owl:Class ; rdfs:comment "An estimated 40% of small bowel cancers are adenocarcinomas, 40% are carcinoids, 15% are sarcomas (GI stromal tumors), and less than 5% are lymphomas." ; rdfs:label "Neoplasm of the small intestine" ; rdfs:subClassOf obo:HP_0007378 . obo:HP_0100834 obo:IAO_0000115 "The presence of a neoplasm of the large intestine." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:03:45Z" ; oboInOwl:hasDbXref "MSH:D015179", "NCIT:C3262", "SNOMEDCT_US:126837005", "UMLS:C0009404" ; oboInOwl:hasExactSynonym "Large intestine tumor", "Large intestine tumour" ; oboInOwl:id "HP:0100834" ; a owl:Class ; rdfs:label "Neoplasm of the large intestine" ; rdfs:subClassOf obo:HP_0002250, obo:HP_0007378 . obo:HP_0100835 dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:08:47Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:92048008", "UMLS:C0347509" ; oboInOwl:hasExactSynonym "Benign neoplasm of the CNS" ; oboInOwl:id "HP:0100835" ; a owl:Class ; rdfs:label "Benign neoplasm of the central nervous system" ; rdfs:subClassOf obo:HP_0100006 . obo:HP_0100836 obo:IAO_0000115 "A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:09:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:372062007", "UMLS:C0348374" ; oboInOwl:hasExactSynonym "Malignant neoplasm of the CNS" ; oboInOwl:id "HP:0100836" ; a owl:Class ; rdfs:label "Malignant neoplasm of the central nervous system" ; rdfs:subClassOf obo:HP_0100006 . obo:HP_0100837 obo:IAO_0000115 "Symmetrical vermiform facial atrophy that affects mainly the forehead, the chin, the ear lobes and helices. Atrophodermia vermiculata is characterized by erythema and follicular plugs on the cheeks, developing into painless reticular impressions." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:20:04Z" ; oboInOwl:hasDbXref "MSH:C537412", "SNOMEDCT_US:400059005", "SNOMEDCT_US:400126005", "UMLS:C0263428" ; oboInOwl:hasExactSynonym "Vermiculata atrophoderma" ; oboInOwl:id "HP:0100837" ; a owl:Class ; rdfs:comment "The onset of atrophodermia vermiculata is usually between the ages of 5 and 12 years." ; rdfs:label "Atrophodermia vermiculata" ; rdfs:subClassOf obo:HP_0000987, obo:HP_0011799 . obo:HP_0100838 obo:IAO_0000115 "An increased susceptibility to cutaneous abscess formation, as manifested by a medical history of recurrent cutaneous abscesses." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:35:07Z" ; oboInOwl:hasDbXref "UMLS:C4021957" ; oboInOwl:id "HP:0100838" ; a owl:Class ; rdfs:label "Recurrent cutaneous abscess formation" ; rdfs:subClassOf obo:HP_0002722, obo:HP_0005406, obo:HP_0031292 . obo:HP_0100839 obo:IAO_0000115 "Absence of the liver owing to a failure of the liver to develop." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:37:25Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:3650004", "UMLS:C0266258" ; oboInOwl:hasExactSynonym "Failed liver development", "Liver agenesis" ; oboInOwl:id "HP:0100839" ; a owl:Class ; rdfs:label "Hepatic agenesis" ; rdfs:subClassOf obo:HP_0034181 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100840 obo:IAO_0000115 "Absence or underdevelopment of the eyebrow." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:40:51Z" ; oboInOwl:hasDbXref "UMLS:C1848765", "UMLS:C2266639", "UMLS:C3551430", "UMLS:C4021956" ; oboInOwl:hasExactSynonym "Absence of eyebrow", "Agenesis of eyebrow", "Hypotrophic eyebrow", "Lack of eyebrow", "Missing eyebrow" ; oboInOwl:hasRelatedSynonym "Sparse or absent eyebrows", "Sparse to absent eyebrows", "Sparse/absent eyebrows" ; oboInOwl:id "HP:0100840" ; a owl:Class ; rdfs:label "Aplasia/Hypoplasia of the eyebrow" ; rdfs:subClassOf obo:HP_0000534 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010163 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100841 obo:IAO_0000115 "A developmental anomaly wtih a small tubular or saccular midline stomach." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:42:10Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:83714006", "UMLS:C0266150" ; oboInOwl:id "HP:0100841" ; a owl:Class ; rdfs:comment "Patients with microgastria usually have poor growth, inadequate food consumption, or a complication of the small gastric cavity and gastroesophageal reflux, including frequent vomiting or pneumonia." ; rdfs:label "Microgastria" ; rdfs:subClassOf obo:HP_0002577 . obo:HP_0100842 obo:IAO_0000115 "Underdevelopment of the optic nerve and absence of the septum pellucidum." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:44:12Z" ; oboInOwl:hasDbXref "MSH:D025962", "SNOMEDCT_US:7611002", "UMLS:C0338503" ; oboInOwl:hasExactSynonym "De Morsier syndrome" ; oboInOwl:id "HP:0100842" ; a owl:Class ; rdfs:label "Septo-optic dysplasia" ; rdfs:subClassOf obo:HP_0000609, obo:HP_0001331 . obo:HP_0100843 obo:IAO_0100001 "HP:0012174" ; oboInOwl:creation_date "2011-06-09T06:47:23Z" ; oboInOwl:id "HP:0100843" ; a owl:Class ; rdfs:label "obsolete Glioblastoma" ; owl:deprecated true . obo:HP_0100844 dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:50:10Z" ; oboInOwl:hasDbXref "MSH:D010185", "SNOMEDCT_US:25803005", "UMLS:C0030290" ; oboInOwl:id "HP:0100844" ; a owl:Class ; rdfs:label "Pancreatic fistula" ; rdfs:subClassOf obo:HP_0012090 . obo:HP_0100845 obo:IAO_0000115 "An acute hypersensitivity reaction due to exposure to a previously encountered antigen." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T06:54:40Z" ; oboInOwl:hasDbXref "MSH:D000707", "SNOMEDCT_US:39579001", "UMLS:C0002792" ; oboInOwl:hasExactSynonym "Anaphylaxis" ; oboInOwl:id "HP:0100845" ; a owl:Class ; rdfs:comment "Anaphylaxis may lead to rapidly progressing urticaria, respiratory distress, vascular collapse, systemic shock, and death if untreated." ; rdfs:label "Anaphylactic shock" ; rdfs:subClassOf obo:HP_0100326 . obo:HP_0100847 obo:IAO_0000115 "A chronic, relapsing, pustular eruption that is localized to the palms and soles." ; dcterms:creator ; oboInOwl:creation_date "2011-06-09T07:07:06Z" ; oboInOwl:hasDbXref "MEDDRA:10050185", "MSH:D011565", "SNOMEDCT_US:27520001", "UMLS:C0030246" ; oboInOwl:hasExactSynonym "Palmoplantar pustules", "Pustulosis of palms and soles", "Pustulosis palmaris et plantaris" ; oboInOwl:id "HP:0100847" ; a owl:Class ; rdfs:comment "There are recurrent and painful eruptions of pustules on the palms and the soles of feet that may resolve with red-brown discoloration." ; rdfs:label "Palmoplantar pustulosis" ; rdfs:subClassOf obo:HP_0011356, obo:HP_0200039 . obo:HP_0100848 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the male external genitalia." ; dcterms:creator ; oboInOwl:creation_date "2011-06-17T01:33:06Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4020950" ; oboInOwl:hasExactSynonym "Neoplasia of the male external genitalia" ; oboInOwl:id "HP:0100848" ; a owl:Class ; rdfs:label "Neoplasm of the male external genitalia" ; rdfs:subClassOf obo:HP_0000032, obo:HP_0033019 . obo:HP_0100849 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the scrotum." ; dcterms:creator ; oboInOwl:creation_date "2011-06-17T01:37:49Z" ; oboInOwl:hasDbXref "NCIT:C3262", "SNOMEDCT_US:126905005", "UMLS:C0341790" ; oboInOwl:hasExactSynonym "Neoplasia of the scrotum", "Scrotum tumor", "Scrotum tumour" ; oboInOwl:id "HP:0100849" ; a owl:Class ; rdfs:label "Neoplasm of the scrotum" ; rdfs:subClassOf obo:HP_0000045, obo:HP_0100848 . obo:HP_0100850 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of the penis." ; dcterms:creator ; oboInOwl:creation_date "2011-06-17T01:38:16Z" ; oboInOwl:hasDbXref "MSH:D010412", "NCIT:C3262", "SNOMEDCT_US:126896003", "UMLS:C0030849" ; oboInOwl:hasExactSynonym "Neoplasia of the penis", "Penis tumor", "Penis tumour" ; oboInOwl:id "HP:0100850" ; a owl:Class ; rdfs:label "Neoplasm of the penis" ; rdfs:subClassOf obo:HP_0000036, obo:HP_0100848 . obo:HP_0100851 obo:IAO_0000115 "An abnormality of emotional behaviour." ; dcterms:creator ; oboInOwl:creation_date "2011-06-23T11:07:13Z" ; oboInOwl:hasDbXref "UMLS:C4020949" ; oboInOwl:hasExactSynonym "Abnormal emotion/affect behaviour" ; oboInOwl:id "HP:0100851" ; a owl:Class ; rdfs:label "Abnormal emotion/affect behavior" ; rdfs:subClassOf obo:HP_0000708 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100852 obo:IAO_0000115 "An abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response." ; dcterms:creator ; oboInOwl:creation_date "2011-06-23T11:13:16Z" ; oboInOwl:hasAlternativeId "HP:0001296" ; oboInOwl:hasDbXref "UMLS:C4018849" ; oboInOwl:hasExactSynonym "Abnormal fear/anxiety-related behaviour" ; oboInOwl:id "HP:0100852" ; a owl:Class ; rdfs:label "Abnormal fear/anxiety-related behavior" ; rdfs:subClassOf obo:HP_0031466 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:NBO_0000018 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100853 obo:IAO_0000115 "Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T09:41:44Z" ; oboInOwl:hasAlternativeId "HP:0006609" ; oboInOwl:hasDbXref "UMLS:C3276032" ; oboInOwl:hasExactSynonym "Hypoplastic areolae" ; oboInOwl:id "HP:0100853" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Hypoplastic areola" ; rdfs:subClassOf obo:HP_0032314 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002032 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100854 obo:IAO_0000115 "Absence of the musculature." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T09:51:08Z" ; oboInOwl:hasDbXref "UMLS:C4021955" ; oboInOwl:hasExactSynonym "Absent musculature" ; oboInOwl:id "HP:0100854" ; a owl:Class ; rdfs:label "Aplasia of the musculature" ; rdfs:subClassOf obo:HP_0001460 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001630 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100855 obo:IAO_0000115 "Hypoplasia of the triceps muscle." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T09:56:14Z" ; oboInOwl:hasDbXref "UMLS:C4021954" ; oboInOwl:hasExactSynonym "Small triceps", "Underdeveloped triceps" ; oboInOwl:id "HP:0100855" ; a owl:Class ; rdfs:label "Triceps hypoplasia" ; rdfs:subClassOf obo:HP_0009784, obo:HP_0030239 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001509 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100856 obo:IAO_0000115 "Decreased ossification of the vertebral bodies." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T09:59:32Z" ; oboInOwl:hasDbXref "UMLS:C4021953" ; oboInOwl:id "HP:0100856" ; a owl:Class ; rdfs:label "Poorly ossified vertebrae" ; rdfs:subClassOf obo:HP_0004599 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002302 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100857 obo:IAO_0000115 "An abnormally flat sella turcica." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:02:07Z" ; oboInOwl:hasDbXref "UMLS:C4021952" ; oboInOwl:id "HP:0100857" ; a owl:Class ; rdfs:label "Flat sella turcica" ; rdfs:subClassOf obo:HP_0002681 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000407 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100858 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of the celiac artery." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:07:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:111290000", "UMLS:C0264969" ; oboInOwl:hasExactSynonym "Dilatation of coeliac artery" ; oboInOwl:hasNarrowSynonym "Celiac artery aneurysm", "Coeliac artery aneurysm" ; oboInOwl:id "HP:0100858" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of celiac artery" ; rdfs:subClassOf obo:HP_0002636 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002093 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001640 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100859 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of the superior mesenteric artery ." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:07:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:65498003", "UMLS:C0264974" ; oboInOwl:hasNarrowSynonym "Superior mesenteric artery aneurysm" ; oboInOwl:id "HP:0100859" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of superior mesenteric artery" ; rdfs:subClassOf obo:HP_0011934 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002093 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001182 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100860 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery ." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:07:35Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:195289005", "UMLS:C0340625" ; oboInOwl:hasNarrowSynonym "Inferior mesenteric artery aneurysm" ; oboInOwl:id "HP:0100860" ; a owl:Class ; rdfs:comment "Aneurysm is considered a severe form of dilatation." ; rdfs:label "Dilatation of Inferior mesenteric artery" ; rdfs:subClassOf obo:HP_0011934 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002093 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001183 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100861 obo:IAO_0000115 "Increase in bone density of the vertebral body." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:12:34Z" ; oboInOwl:hasAlternativeId "HP:0004578" ; oboInOwl:hasDbXref "UMLS:C4021951" ; oboInOwl:hasExactSynonym "Vertebral body sclerosis" ; oboInOwl:id "HP:0100861" ; a owl:Class ; rdfs:label "Sclerotic vertebral body" ; rdfs:subClassOf obo:HP_0003468 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001075 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100862 dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:47:46Z" ; oboInOwl:hasDbXref "UMLS:C4021950" ; oboInOwl:hasExactSynonym "Absent femoral head" ; oboInOwl:id "HP:0100862" ; a owl:Class ; rdfs:label "Aplasia of the femoral head" ; rdfs:subClassOf obo:HP_0009108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100863 dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:48:08Z" ; oboInOwl:hasDbXref "UMLS:C4021949" ; oboInOwl:hasExactSynonym "Absent neck of thighbone" ; oboInOwl:id "HP:0100863" ; a owl:Class ; rdfs:label "Aplasia of the femoral neck" ; rdfs:subClassOf obo:HP_0009108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100864 obo:IAO_0000115 "An abnormally short femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T10:48:34Z" ; oboInOwl:hasAlternativeId "HP:0003032", "HP:0008779", "HP:0008793" ; oboInOwl:hasDbXref "UMLS:C1836184" ; oboInOwl:hasExactSynonym "Hypoplasia of the femoral neck", "Hypoplastic femoral neck", "Short femoral necks", "Short neck of thighbone" ; oboInOwl:id "HP:0100864" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Short femoral neck" ; rdfs:subClassOf obo:HP_0003367, obo:HP_0009108 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007119 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100865 obo:IAO_0000115 "Increased width of the ischium, which forms the lower and back part of the hip bone." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:09:10Z" ; oboInOwl:hasAlternativeId "HP:0008814" ; oboInOwl:hasDbXref "UMLS:C1836868" ; oboInOwl:id "HP:0100865" ; a owl:Class ; rdfs:label "Broad ischia" ; rdfs:subClassOf obo:HP_0003174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001274 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100866 obo:IAO_0000115 "Underdevelopment of the iliac bones." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:11:24Z" ; oboInOwl:hasDbXref "UMLS:C1849063" ; oboInOwl:hasExactSynonym "Short pelvis bones" ; oboInOwl:id "HP:0100866" ; a owl:Class ; rdfs:label "Short iliac bones" ; rdfs:subClassOf obo:HP_0000946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000569 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100867 obo:IAO_0000115 "The narrowing or partial blockage of a portion of the duodenum." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:13:27Z" ; oboInOwl:hasAlternativeId "HP:0005205", "HP:0010449" ; oboInOwl:hasDbXref "MEDDRA:10050094", "MSH:C535720", "SNOMEDCT_US:73120006", "UMLS:C0238093", "UMLS:C1860791" ; oboInOwl:hasExactSynonym "Duodenal stenosis/atresia" ; oboInOwl:id "HP:0100867" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Duodenal stenosis" ; rdfs:subClassOf obo:HP_0002246, obo:HP_0012848 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100869 obo:IAO_0000115 "The presence of telangiectases on the skin of palm of hand." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:19:45Z" ; oboInOwl:hasAlternativeId "HP:0007399" ; oboInOwl:hasDbXref "UMLS:C4020948" ; oboInOwl:hasExactSynonym "Telangiectases of palms and soles", "Teleangiectases of palms" ; oboInOwl:id "HP:0100869" ; a owl:Class ; rdfs:label "Palmar telangiectasia" ; rdfs:subClassOf obo:HP_0040211, obo:HP_0100585 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013777 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100870 obo:IAO_0000115 "Telangiectases (small dilated blood vessels) located on the skin of sole of foot." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:19:59Z" ; oboInOwl:hasDbXref "UMLS:C4020947" ; oboInOwl:hasExactSynonym "Plantar teleangiectasia", "Telangiectases of soles", "Teleangiectases of soles" ; oboInOwl:id "HP:0100870" ; a owl:Class ; rdfs:label "Plantar telangiectasia" ; rdfs:subClassOf obo:HP_0100585, obo:HP_0100872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013778 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100871 obo:IAO_0000115 "An abnormality of the palm, that is, of the front of the hand." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:21:16Z" ; oboInOwl:hasDbXref "UMLS:C4021948" ; oboInOwl:hasExactSynonym "Abnormality of the palm" ; oboInOwl:id "HP:0100871" ; a owl:Class ; rdfs:label "Abnormal palm morphology" ; rdfs:subClassOf obo:HP_0001155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008878 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100872 obo:IAO_0000115 "An abnormality of the plantar part of foot, that is of the soles of the feet." ; dcterms:creator ; oboInOwl:creation_date "2011-11-30T11:23:05Z" ; oboInOwl:hasAlternativeId "HP:0010613" ; oboInOwl:hasDbXref "UMLS:C4020946" ; oboInOwl:hasExactSynonym "Minor feet anomalies" ; oboInOwl:id "HP:0100872" ; a owl:Class ; rdfs:label "Abnormality of the plantar skin of foot" ; rdfs:subClassOf obo:HP_0001760, obo:HP_0011356 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100874 obo:IAO_0000115 "Increased density of hairs, i.e., and elevated number of hairs per unit area." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:13:58Z" ; oboInOwl:hasDbXref "UMLS:C4073184" ; oboInOwl:hasExactSynonym "Increased follicular density", "Increased hair density", "Thick hair" ; oboInOwl:id "HP:0100874" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Thick hair" ; rdfs:subClassOf obo:HP_0011362 . obo:HP_0100875 obo:IAO_0000115 "Increased length and width of one half of the tounge." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:15:01Z" ; oboInOwl:hasBroadSynonym "Hemiglossal hyperplasia", "Hyperplasia of half of the tongue" ; oboInOwl:hasDbXref "UMLS:C4021947", "UMLS:C4280287" ; oboInOwl:hasExactSynonym "Hemiglossal hypertrophy", "Hypertrophy of half of the tongue", "Increased size of half of the tongue", "Large half of tongue" ; oboInOwl:id "HP:0100875" ; a owl:Class ; rdfs:label "Hemimacroglossia" ; rdfs:subClassOf obo:HP_0000158 . obo:HP_0100876 obo:IAO_0000115 "Skin crease extending from below the inner canthus laterally along the malar process of the maxilla and zygoma." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:21:22Z" ; oboInOwl:hasAlternativeId "HP:0007796" ; oboInOwl:hasDbXref "UMLS:C1857280" ; oboInOwl:hasExactSynonym "Crease in skin under the eye", "Groove in skin under the eye", "Infraorbital crease", "Infraorbital creases", "Underorbital skin creases" ; oboInOwl:id "HP:0100876" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:comment "This feature is often found in the presence of hypoplasia of the malar process of the maxilla or zygoma, but should be coded separately." ; rdfs:label "Infra-orbital crease" ; rdfs:subClassOf obo:HP_0000606 . obo:HP_0100877 obo:IAO_0000115 "Cystic, urine-containing intrarenal cavities lined with transitional cell epithelium that communicate through a narrow channel with the collecting system." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:29:09Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:433036004", "UMLS:C2315541" ; oboInOwl:hasExactSynonym "Caliceal diverticulum", "Pelvic diverticulum", "Renal pelvic diverticulum" ; oboInOwl:id "HP:0100877" ; a owl:Class ; rdfs:label "Renal diverticulum" ; rdfs:subClassOf obo:HP_0000107, obo:HP_0004742 . obo:HP_0100878 dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:32:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:198319004", "UMLS:C0151994" ; oboInOwl:hasExactSynonym "Enlarged uterus" ; oboInOwl:id "HP:0100878" ; a owl:Class ; rdfs:label "Enlarged uterus" ; rdfs:subClassOf obo:HP_0031105 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100879 dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:33:12Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:66998000", "UMLS:C0392039" ; oboInOwl:hasExactSynonym "Enlarged ovaries" ; oboInOwl:id "HP:0100879" ; a owl:Class ; rdfs:label "Enlarged ovaries" ; rdfs:subClassOf obo:HP_0031065 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000992 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100880 obo:IAO_0000115 "Abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:41:34Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:405933007", "UMLS:C1320468" ; oboInOwl:id "HP:0100880" ; a owl:Class ; rdfs:comment "Though NR are best known as precursors of Wilms tumor (WT), many alternative fates are observed, and most rests are destined for eventual atresia. Nephroblastomatosis refers to the presence of multifocal or diffuse nephrogenic rests." ; rdfs:label "Nephrogenic rest" ; rdfs:subClassOf obo:HP_0012210 . obo:HP_0100881 obo:IAO_0000115 "Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:44:52Z" ; oboInOwl:hasDbXref "MSH:D018201", "UMLS:C1332965" ; oboInOwl:id "HP:0100881" ; a owl:Class ; rdfs:comment "Congenital mesoblastic nephroma is more common in males." ; rdfs:label "Congenital mesoblastic nephroma" ; rdfs:subClassOf obo:HP_0003549, obo:HP_0011794 . obo:HP_0100882 obo:IAO_0000115 "A rare, benign soft tissue tumor that typically occurs within the first two years of life." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:48:30Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:22257004", "SNOMEDCT_US:56364004", "UMLS:C0265979" ; oboInOwl:hasExactSynonym "Fibrous hamartoma of infancy" ; oboInOwl:id "HP:0100882" ; a owl:Class ; rdfs:label "Fibrous hamartoma" ; rdfs:subClassOf obo:HP_0010566 . obo:HP_0100883 obo:IAO_0000115 "Hamartoma-like growth in the placenta consisting of blood vessels." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:50:56Z" ; oboInOwl:hasDbXref "MSH:D006391", "SNOMEDCT_US:2099007", "SNOMEDCT_US:237268002", "SNOMEDCT_US:699948001", "UMLS:C0677608" ; oboInOwl:hasExactSynonym "Placental hamartoma" ; oboInOwl:id "HP:0100883" ; a owl:Class ; rdfs:comment "Chorioangiomas (also known as placental hemangiomas) are benign hamartomatous growth of the placenta comprising vascular tissue. The classification is controversial due to its pathologic features and clinical implications. Some authors call placental hemangiomas as true nontrophoblastic neoplastic tissues. As this abnormal vascular growth seems like the native placental tissue and it does not metastasize, some authors call it just as placental hamartoma. The general incidence is approximately 0.6 percent. Giant chorioangiomas with a diameter over 5 cm are very rare, with an incidence of one in 16-50 thousand pregnancies. Small tumors do not cause any adverse outcomes and they are asymptomatic. In contrast, tumors larger than 5 cm may lead to several complications." ; rdfs:label "Chorangioma" ; rdfs:subClassOf obo:HP_0010566, obo:HP_0100767 . obo:HP_0100884 obo:IAO_0000115 "A scoliosis which is the results of a difference in leg length (which might be due to hemihypertrophy or hemihypotrophy of a leg) and the resulting tilting of the pelvis. If untreated this will lead to the development of scoliosis over time." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T02:56:41Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:203645000", "UMLS:C0343292" ; oboInOwl:id "HP:0100884" ; a owl:Class ; rdfs:label "Compensatory scoliosis" ; rdfs:subClassOf obo:HP_0002650 . obo:HP_0100885 obo:IAO_0000115 "Persistence of the embryonic dorsal or sciatic vein system that normally should have involuted around the tenth to twelfth week of intrauterine life." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T03:16:02Z" ; oboInOwl:hasDbXref "UMLS:C4020945" ; oboInOwl:hasExactSynonym "Klippel-Trenaunay vein", "Lateral marginal vein of Servelle", "Vein of Servelle" ; oboInOwl:id "HP:0100885" ; a owl:Class ; rdfs:comment """Embryonic leg veins usually regress before birth, but in Klippel-Trenaunay syndrome (KTS) a persistent embryonic vein (PEV) may be located on the lateral aspect of the affected leg. Known PEVs of the leg are the lateral marginal vein (LMV) and the persistent sciatic vein (PSV). The nomenclature can be confusing because various terms are used to indicate the same aberrant leg vein in KTS (e.g. vein of Servelle, Klippel-Trenaunay vein, lateral marginal vein).""" ; rdfs:label "Lateral venous anomaly" ; rdfs:subClassOf obo:HP_0001015 . obo:HP_0100886 obo:IAO_0000115 "An abnormality in the placement of the ocular globe (eyeball)." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T04:25:29Z" ; oboInOwl:hasDbXref "UMLS:C4021946" ; oboInOwl:hasExactSynonym "Abnormality of eyeball location", "Abnormality of eyeball position", "Abnormality of globe position" ; oboInOwl:id "HP:0100886" ; a owl:Class ; rdfs:label "Abnormality of globe location" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100887 obo:IAO_0000115 "An abnormality in the size of the ocular globe (eyeball)." ; dcterms:creator ; oboInOwl:creation_date "2011-12-13T04:25:29Z" ; oboInOwl:hasAlternativeId "HP:0010725" ; oboInOwl:hasDbXref "UMLS:C4021945" ; oboInOwl:hasExactSynonym "Abnormality of eyeball size", "Eye size difference" ; oboInOwl:id "HP:0100887" ; a owl:Class ; rdfs:label "Abnormality of globe size" ; rdfs:subClassOf obo:HP_0012372 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100888 dcterms:creator ; oboInOwl:creation_date "2011-12-01T04:50:01Z" ; oboInOwl:hasDbXref "UMLS:C4021944" ; oboInOwl:id "HP:0100888" ; a owl:Class ; rdfs:label "Interdigital loops" ; rdfs:subClassOf obo:HP_0007477 . obo:HP_0100889 obo:IAO_0000115 "An abnormality of the Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract, formed by the union of the Common hepatic duct and the Cystic duct from the gall bladder." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T04:52:13Z" ; oboInOwl:hasDbXref "UMLS:C4020944" ; oboInOwl:hasExactSynonym "Abnormality of the common bile duct", "Abnormality of the ductus choledochus" ; oboInOwl:id "HP:0100889" ; a owl:Class ; rdfs:label "Abnormal ductus choledochus morphology" ; rdfs:subClassOf obo:HP_0012440 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001174 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100890 dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:02:35Z" ; oboInOwl:hasDbXref "MSH:D015529", "SNOMEDCT_US:397868007", "SNOMEDCT_US:398197009", "SNOMEDCT_US:440471007", "UMLS:C0008340" ; oboInOwl:hasExactSynonym "Choledochal cyst" ; oboInOwl:id "HP:0100890" ; a owl:Class ; rdfs:label "Cyst of the ductus choledochus" ; rdfs:subClassOf obo:HP_0100889 . obo:HP_0100891 obo:IAO_0000115 "A cleft of the xiphoid process of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:07:17Z" ; oboInOwl:hasDbXref "UMLS:C4020943" ; oboInOwl:hasExactSynonym "Bifid xiphisternum" ; oboInOwl:id "HP:0100891" ; a owl:Class ; rdfs:label "Bifid xiphoid process" ; rdfs:subClassOf obo:HP_0100892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100892 obo:IAO_0000115 "An abnormality of the xiphoid process of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:09:03Z" ; oboInOwl:hasDbXref "UMLS:C4021943" ; oboInOwl:id "HP:0100892" ; a owl:Class ; rdfs:label "Abnormality of the xiphoid process" ; rdfs:subClassOf obo:HP_0000766 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100893 obo:IAO_0000115 "Increased prominence of the xiphoid process of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:10:05Z" ; oboInOwl:hasDbXref "UMLS:C4020942" ; oboInOwl:hasExactSynonym "Prominent xiphisternum" ; oboInOwl:id "HP:0100893" ; a owl:Class ; rdfs:label "Prominent xiphoid process" ; rdfs:subClassOf obo:HP_0100892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001482 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100894 obo:IAO_0000115 "Increased side-to-side width of the xiphoid process of the sternum." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:10:27Z" ; oboInOwl:hasDbXref "UMLS:C4020901" ; oboInOwl:hasExactSynonym "Broad xiphisternum" ; oboInOwl:id "HP:0100894" ; a owl:Class ; rdfs:label "Broad xiphoid process" ; rdfs:subClassOf obo:HP_0100892 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000600 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002207 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100896 obo:IAO_0000115 "The presence of multiple rectal hyperplastic/adenomatous polyps." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:33:49Z" ; oboInOwl:hasAlternativeId "HP:0100897" ; oboInOwl:hasDbXref "SNOMEDCT_US:39772007", "UMLS:C0034887" ; oboInOwl:hasExactSynonym "Multiple rectal polyps", "Rectal polyps" ; oboInOwl:id "HP:0100896" ; a owl:Class ; rdfs:label "Rectal polyposis" ; rdfs:subClassOf obo:HP_0030255, obo:HP_0100743 . obo:HP_0100898 obo:IAO_0000115 "Connective tissue nevi are hamartomas in which one or several components of the dermis is altered." ; dcterms:creator ; oboInOwl:creation_date "2011-12-01T05:39:30Z" ; oboInOwl:hasDbXref "MSH:C562737", "SNOMEDCT_US:22858003", "SNOMEDCT_US:400091006", "UMLS:C0334083" ; oboInOwl:id "HP:0100898" ; a owl:Class ; rdfs:comment "Lesions in which collagen predominates are called collagenomas; lesions in which elastin predominates are called elastomas. A nevus mucinosis is a lesion in which an alteration in the amount of dermal glycosaminoglycan is present. The name nevus mucinosis is also used for lesions in which an alteration in more than one dermal component is present. Connective tissue nevi may be solitary or multiple, sporadic or inherited. They may occur as isolated skin lesions, or they may be associated with a number of syndromes." ; rdfs:label "Connective tissue nevi" ; rdfs:subClassOf obo:HP_0003549, obo:HP_0003764 . obo:HP_0100899 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T09:34:05Z" ; oboInOwl:hasDbXref "UMLS:C4020941" ; oboInOwl:hasExactSynonym "Increased bone density in the finger bone", "Sclerosis of the phalanges of the hand" ; oboInOwl:id "HP:0100899" ; a owl:Class ; rdfs:label "Sclerosis of finger phalanx" ; rdfs:subClassOf obo:HP_0004054, obo:HP_0005918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100900 oboInOwl:hasDbXref "UMLS:C4021942" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the index finger" ; oboInOwl:id "HP:0100900" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0100915, obo:HP_0100918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100901 oboInOwl:hasDbXref "UMLS:C4021941" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the middle finger" ; oboInOwl:id "HP:0100901" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0100915, obo:HP_0100919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100902 oboInOwl:hasDbXref "UMLS:C4021940" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the ring finger" ; oboInOwl:id "HP:0100902" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0100915, obo:HP_0100920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100903 oboInOwl:hasDbXref "UMLS:C4021939" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost little finger bone", "Increased bone density in the outermost pinkie finger bone", "Increased bone density in the outermost pinky finger bone" ; oboInOwl:id "HP:0100903" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0100915, obo:HP_0100921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100904 oboInOwl:hasDbXref "UMLS:C4021938" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the index finger" ; oboInOwl:id "HP:0100904" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0100916, obo:HP_0100918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100905 oboInOwl:hasDbXref "UMLS:C4021937" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the middle finger" ; oboInOwl:id "HP:0100905" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0100916, obo:HP_0100919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100906 oboInOwl:hasDbXref "UMLS:C4021936" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the ring finger" ; oboInOwl:id "HP:0100906" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0100916, obo:HP_0100920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100907 oboInOwl:hasDbXref "UMLS:C4021935" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the little finger", "Increased bone density in the middle bone of the pinkie finger", "Increased bone density in the middle bone of the pinky finger" ; oboInOwl:id "HP:0100907" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0100916, obo:HP_0100921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100908 oboInOwl:hasDbXref "UMLS:C4021934" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the index finger" ; oboInOwl:id "HP:0100908" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 2nd finger" ; rdfs:subClassOf obo:HP_0100917, obo:HP_0100918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100909 oboInOwl:hasDbXref "UMLS:C4021933" ; oboInOwl:hasExactSynonym "Increased bone density in innermost bone of the middle finger" ; oboInOwl:id "HP:0100909" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 3rd finger" ; rdfs:subClassOf obo:HP_0100917, obo:HP_0100919 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100910 oboInOwl:hasDbXref "UMLS:C4021932" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the ring finger" ; oboInOwl:id "HP:0100910" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 4th finger" ; rdfs:subClassOf obo:HP_0100917, obo:HP_0100920 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100911 oboInOwl:hasDbXref "UMLS:C4021931" ; oboInOwl:hasExactSynonym "Increased bone density in innermost little finger bone", "Increased bone density in innermost pinkie finger bone", "Increased bone density in innermost pinky finger bone" ; oboInOwl:id "HP:0100911" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 5th finger" ; rdfs:subClassOf obo:HP_0100917, obo:HP_0100921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100912 obo:IAO_0000115 "An elevation of bone density in the distal phalanx of the thumb." ; oboInOwl:hasDbXref "UMLS:C4021930" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the thumb" ; oboInOwl:id "HP:0100912" ; a owl:Class ; rdfs:comment "Sclerosis can be identified on a radiograph as an area of increased opacity." ; rdfs:label "Sclerosis of the distal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0100915, obo:HP_0100922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100913 obo:IAO_0000115 "An elevation of bone density in the proximal phalanx of the thumb." ; oboInOwl:hasDbXref "UMLS:C4021929" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the thumb" ; oboInOwl:id "HP:0100913" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the thumb" ; rdfs:subClassOf obo:HP_0100916, obo:HP_0100922 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100914 oboInOwl:hasDbXref "UMLS:C4021928" ; oboInOwl:hasExactSynonym "Increased bone density in 1st long bone of hand" ; oboInOwl:id "HP:0100914" ; a owl:Class ; rdfs:label "Sclerosis of the 1st metacarpal" ; rdfs:subClassOf obo:HP_0100917 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100915 obo:IAO_0000115 "An elevation in bone density in one or more distal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020940" ; oboInOwl:hasExactSynonym "Increased bone density in outermost finger bone", "Sclerosis of the distal phalanges of the hand" ; oboInOwl:id "HP:0100915" ; a owl:Class ; rdfs:label "Sclerosis of distal finger phalanx" ; rdfs:subClassOf obo:HP_0009832, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100916 obo:IAO_0000115 "An elevation in bone density in one or more middle phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020939" ; oboInOwl:hasExactSynonym "Increased bone density in middle finger bone of hand", "Sclerosis of the middle phalanges of the hand" ; oboInOwl:id "HP:0100916" ; a owl:Class ; rdfs:label "Sclerosis of middle finger phalanx" ; rdfs:subClassOf obo:HP_0009833, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003864 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100917 obo:IAO_0000115 "An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020938" ; oboInOwl:hasExactSynonym "Increased bone density in innermost finger bone", "Sclerosis of the proximal phalanges of the hand" ; oboInOwl:id "HP:0100917" ; a owl:Class ; rdfs:label "Sclerosis of proximal finger phalanx" ; rdfs:subClassOf obo:HP_0009834, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100918 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the second finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020937" ; oboInOwl:hasExactSynonym "Increased bone density in 2nd finger bone", "Sclerosis of the phalanges of the 2nd finger" ; oboInOwl:id "HP:0100918" ; a owl:Class ; rdfs:label "Sclerosis of 2nd finger phalanx" ; rdfs:subClassOf obo:HP_0009541, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100919 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the third finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020936" ; oboInOwl:hasExactSynonym "Increased bone density in middle finger bone", "Sclerosis of the phalanges of the 3rd finger" ; oboInOwl:id "HP:0100919" ; a owl:Class ; rdfs:label "Sclerosis of 3rd finger phalanx" ; rdfs:subClassOf obo:HP_0009316, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100920 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the fourth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020935" ; oboInOwl:hasExactSynonym "Increased bone density in ring finger bone", "Sclerosis of the phalanges of the 4th finger" ; oboInOwl:id "HP:0100920" ; a owl:Class ; rdfs:label "Sclerosis of 4th finger phalanx" ; rdfs:subClassOf obo:HP_0009172, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100921 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the fifth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020934" ; oboInOwl:hasExactSynonym "Increased bone density in little finger bone", "Increased bone density in pinkie finger bone", "Increased bone density in pinky finger bone", "Sclerosis of the phalanges of the 5th finger" ; oboInOwl:id "HP:0100921" ; a owl:Class ; rdfs:label "Sclerosis of 5th finger phalanx" ; rdfs:subClassOf obo:HP_0004213, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100922 oboInOwl:hasDbXref "UMLS:C4020933" ; oboInOwl:hasExactSynonym "Increased bone density in thumb bone", "Sclerosis of the phalanges of the thumb" ; oboInOwl:id "HP:0100922" ; a owl:Class ; rdfs:label "Sclerosis of thumb phalanx" ; rdfs:subClassOf obo:HP_0009602, obo:HP_0100899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100923 obo:IAO_0000115 "An increase in bone density within the clavicle." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T10:28:41Z" ; oboInOwl:hasAlternativeId "HP:0006648" ; oboInOwl:hasDbXref "UMLS:C3554669" ; oboInOwl:hasExactSynonym "Increased bone density in collarbone", "Osteosclerosis of the clavicle" ; oboInOwl:hasRelatedSynonym "Osteosclerosis of the clavicles" ; oboInOwl:id "HP:0100923" ; a owl:Class ; rdfs:label "Clavicular sclerosis" ; rdfs:subClassOf obo:HP_0000889, obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100924 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T11:08:43Z" ; oboInOwl:hasDbXref "UMLS:C4020932" ; oboInOwl:hasExactSynonym "Increased bone density in the toe bone", "Sclerosis of the phalanges of the toes" ; oboInOwl:id "HP:0100924" ; a owl:Class ; rdfs:label "Sclerosis of toe phalanx" ; rdfs:subClassOf obo:HP_0010161, obo:HP_0100925 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100925 obo:IAO_0000115 "An elevation in bone density in one or more foot bones. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T11:12:32Z" ; oboInOwl:hasDbXref "UMLS:C4020931" ; oboInOwl:hasExactSynonym "Increased bone density in foot bone", "Sclerosis of bones of the feet" ; oboInOwl:id "HP:0100925" ; a owl:Class ; rdfs:label "Sclerosis of foot bone" ; rdfs:subClassOf obo:HP_0011001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001445 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100926 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020930" ; oboInOwl:hasExactSynonym "Increased bone density in 2nd toe bone", "Sclerosis of the phalanges of the 2nd toe" ; oboInOwl:id "HP:0100926" ; a owl:Class ; rdfs:label "Sclerosis of 2nd toe phalanx" ; rdfs:subClassOf obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003641 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100927 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020929" ; oboInOwl:hasExactSynonym "Increased bone density in 3rd toe bone", "Sclerosis of the phalanges of the 3rd toe" ; oboInOwl:id "HP:0100927" ; a owl:Class ; rdfs:label "Sclerosis of 3rd toe phalanx" ; rdfs:subClassOf obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003642 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100928 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the fourth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020928" ; oboInOwl:hasExactSynonym "Increased bone density in 4th toe bone", "Sclerosis of the phalanges of the 4th toe" ; oboInOwl:id "HP:0100928" ; a owl:Class ; rdfs:label "Sclerosis of 4th toe phalanx" ; rdfs:subClassOf obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003862 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100929 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the fifth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020927" ; oboInOwl:hasExactSynonym "Increased bone density in little toe bone", "Increased bone density in pinkie toe bone", "Increased bone density in pinky toe bone", "Sclerosis of the phalanges of the 5th toe" ; oboInOwl:id "HP:0100929" ; a owl:Class ; rdfs:label "Sclerosis of 5th toe phalanx" ; rdfs:subClassOf obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003863 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100930 obo:IAO_0000115 "An elevation in bone density in one or more phalanges of the big toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020926" ; oboInOwl:hasExactSynonym "Increased bone density in big toe bone", "Sclerosis of the phalanges of the hallux" ; oboInOwl:id "HP:0100930" ; a owl:Class ; rdfs:label "Sclerosis of hallux phalanx" ; rdfs:subClassOf obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003640 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100931 obo:IAO_0000115 "An elevation in bone density in the proximal phalanx of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4021927" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the 2nd toe" ; oboInOwl:id "HP:0100931" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100926, obo:HP_0100946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004333 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100932 obo:IAO_0000115 "An elevation in bone density in the proximal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4021926" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the 3rd toe" ; oboInOwl:id "HP:0100932" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100927, obo:HP_0100946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004334 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100933 oboInOwl:hasDbXref "UMLS:C4021925" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the 4th toe" ; oboInOwl:id "HP:0100933" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100928, obo:HP_0100946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004335 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100934 oboInOwl:hasDbXref "UMLS:C4021924" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the little toe", "Increased bone density in the innermost bone of the pinkie toe", "Increased bone density in the innermost bone of the pinky toe" ; oboInOwl:id "HP:0100934" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100929, obo:HP_0100946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004336 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100935 oboInOwl:hasDbXref "UMLS:C4021923" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the 2nd toe" ; oboInOwl:id "HP:0100935" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0100926, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004324 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100936 obo:IAO_0000115 "An elevation in bone density in the middle phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4021922" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the 3rd toe" ; oboInOwl:id "HP:0100936" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100927, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004325 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100937 oboInOwl:hasDbXref "UMLS:C4021921" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the 4th toe" ; oboInOwl:id "HP:0100937" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100928, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004326 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100938 oboInOwl:hasDbXref "UMLS:C4021920" ; oboInOwl:hasExactSynonym "Increased bone density in the middle bone of the little toe", "Increased bone density in the middle bone of the pinkie toe", "Increased bone density in the middle bone of the pinky toe" ; oboInOwl:id "HP:0100938" ; a owl:Class ; rdfs:label "Sclerosis of the middle phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100929, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004327 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100939 oboInOwl:hasDbXref "UMLS:C4021919" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the 2nd toe" ; oboInOwl:id "HP:0100939" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 2nd toe" ; rdfs:subClassOf obo:HP_0010356, obo:HP_0100926, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100940 obo:IAO_0000115 "An elevation in bone density in the distal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4021918" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the 3rd toe" ; oboInOwl:id "HP:0100940" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 3rd toe" ; rdfs:subClassOf obo:HP_0100927, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100941 oboInOwl:hasDbXref "UMLS:C4021917" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the 4th toe" ; oboInOwl:id "HP:0100941" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 4th toe" ; rdfs:subClassOf obo:HP_0100928, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100942 oboInOwl:hasDbXref "UMLS:C4021916" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the little toe", "Increased bone density in the outermost bone of the pinkie toe", "Increased bone density in the outermost bone of the pinky toe" ; oboInOwl:id "HP:0100942" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the 5th toe" ; rdfs:subClassOf obo:HP_0100929, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100943 oboInOwl:hasDbXref "UMLS:C4021915" ; oboInOwl:hasExactSynonym "Increased bone density in the innermost bone of the big toe" ; oboInOwl:id "HP:0100943" ; a owl:Class ; rdfs:label "Sclerosis of the proximal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0100930, obo:HP_0100947 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004332 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100944 oboInOwl:hasDbXref "UMLS:C4021914" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the big toe" ; oboInOwl:id "HP:0100944" ; a owl:Class ; rdfs:label "Sclerosis of the distal phalanx of the hallux" ; rdfs:subClassOf obo:HP_0010053, obo:HP_0100930, obo:HP_0100948 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100945 oboInOwl:hasDbXref "UMLS:C4021913" ; oboInOwl:hasExactSynonym "Increased bone density in the 1st long bone of foot" ; oboInOwl:id "HP:0100945" ; a owl:Class ; rdfs:label "Sclerosis of the 1st metatarsal" ; rdfs:subClassOf obo:HP_0100930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003650 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100946 obo:IAO_0000115 "An elevation in bone density in one or more proximal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020925" ; oboInOwl:hasExactSynonym "Increased bone density in innermost toe bone", "Sclerosis of the proximal phalanges of the toes" ; oboInOwl:id "HP:0100946" ; a owl:Class ; rdfs:label "Sclerosis of proximal toe phalanx" ; rdfs:subClassOf obo:HP_0010184, obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003868 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100947 obo:IAO_0000115 "An elevation in bone density in one or more middle phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020924" ; oboInOwl:hasExactSynonym "Increased bone density in middle toe bone", "Sclerosis of the middle phalanges of the toes" ; oboInOwl:id "HP:0100947" ; a owl:Class ; rdfs:label "Sclerosis of middle toe phalanx" ; rdfs:subClassOf obo:HP_0010183, obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003866 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100948 obo:IAO_0000115 "An elevation in bone density in one or more distal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." ; oboInOwl:hasDbXref "UMLS:C4020923" ; oboInOwl:hasExactSynonym "Increased bone density in the outermost bone of the toes", "Sclerosis of the distal phalanges of the toes" ; oboInOwl:id "HP:0100948" ; a owl:Class ; rdfs:label "Sclerosis of distal toe phalanx" ; rdfs:subClassOf obo:HP_0010182, obo:HP_0100924 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003867 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100950 dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:33:23Z" ; oboInOwl:hasDbXref "MSH:C566945", "SNOMEDCT_US:237999008", "UMLS:C1969443" ; oboInOwl:hasRelatedSynonym "Long chain 3 hydroxyacyl coA dehydrogenase deficiency", "Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency", "Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency" ; oboInOwl:id "HP:0100950" ; a owl:Class ; rdfs:comment "Previously, 3-alpha-hydroxyacyl-CoA dehydrogenase was referred to as short-chain 3-alpha-hydroxyacyl-CoA dehydrogenase as well as medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase." ; rdfs:label "Decreased 3-hydroxyacyl-CoA dehydrogenase level" ; rdfs:subClassOf obo:HP_0003287, obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003857 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100951 dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:45:02Z" ; oboInOwl:hasAlternativeId "HP:0002420" ; oboInOwl:hasDbXref "UMLS:C4020922" ; oboInOwl:hasExactSynonym "Enlarged basal cistern", "Enlarged interpeduncular cistern" ; oboInOwl:id "HP:0100951" ; a owl:Class ; rdfs:label "Enlarged fossa interpeduncularis" ; rdfs:subClassOf obo:HP_0002119 . obo:HP_0100952 obo:IAO_0000115 "An increase in size of the subarachnoid space associated with the lateral cerebral sulcus (Sylvian fissure)." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:47:51Z" ; oboInOwl:hasDbXref "UMLS:C4020921" ; oboInOwl:hasExactSynonym "Enlarged lateral fissure", "Enlarged lateral sulcus", "Enlarged sylvian fissure" ; oboInOwl:id "HP:0100952" ; a owl:Class ; rdfs:label "Enlarged sylvian cistern" ; rdfs:subClassOf obo:HP_0002119 . obo:HP_0100953 dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:49:49Z" ; oboInOwl:hasDbXref "UMLS:C4020920" ; oboInOwl:hasExactSynonym "Enlarged great longitudinal fissure", "Enlarged longitudinal cerebral fissure", "Enlarged longitudinal fissure" ; oboInOwl:id "HP:0100953" ; a owl:Class ; rdfs:label "Enlarged interhemispheric fissure" ; rdfs:subClassOf obo:HP_0012703 . obo:HP_0100954 obo:IAO_0000115 "Underdevelopment of the operculum." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:55:20Z" ; oboInOwl:hasDbXref "UMLS:C2675973" ; oboInOwl:id "HP:0100954" ; a owl:Class ; rdfs:label "Open operculum" ; rdfs:subClassOf obo:HP_0002538, obo:HP_0006872 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010262 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100955 dcterms:creator ; oboInOwl:creation_date "2011-12-02T04:57:10Z" ; oboInOwl:hasDbXref "UMLS:C4021912" ; oboInOwl:id "HP:0100955" ; a owl:Class ; rdfs:label "Giant cell granuloma of mandible" ; rdfs:subClassOf obo:HP_0000277 . obo:HP_0100957 obo:IAO_0000115 "Any structural abnormality of the medulla of the kidney." ; dcterms:creator ; oboInOwl:creation_date "2011-12-12T10:02:15Z" ; oboInOwl:hasAlternativeId "HP:0005582" ; oboInOwl:hasDbXref "UMLS:C4021911" ; oboInOwl:hasExactSynonym "Abnormality of the renal medulla" ; oboInOwl:id "HP:0100957" ; a owl:Class ; rdfs:comment "The renal pyramids of the adult kidney resemble a cone with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla. The adult renal medulla is made up of 10-18 pyramids. A pyramid consists of the medullary collecting ducts, loops of Henle, vasa recta (straight capillaries) and the interstitium. The main function of the medulla is to regulate concentration of the urine. The urine flows from the collecting ducts into the renal calyces and pelvis." ; rdfs:label "Abnormal renal medulla morphology" ; rdfs:subClassOf obo:HP_0012210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000362 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100958 obo:IAO_0000115 "Decreased width of the foramen obturatorium. The foramen obturatorium (also known as the obturator foramen) is a hole located between the ischium and pubis bones of the pelvis." ; dcterms:creator ; oboInOwl:creation_date "2012-01-18T05:17:14Z" ; oboInOwl:hasDbXref "UMLS:C4021910" ; oboInOwl:id "HP:0100958" ; a owl:Class ; rdfs:label "Narrow foramen obturatorium" ; rdfs:subClassOf obo:HP_0003172, obo:HP_0003174 . obo:HP_0100959 obo:IAO_0000115 "Dense radiopaque bands of bone which are thicker than the adjacent diaphyseal cortex and may form at the metaphysis of growing bones. They appear on radiographs as bone that is more radiopaque that the adjacent diaphyseal cortex." ; dcterms:creator ; oboInOwl:creation_date "2012-01-18T05:25:57Z" ; oboInOwl:hasDbXref "UMLS:C4020919" ; oboInOwl:hasExactSynonym "Dense metaphyseal band sign", "Dense metaphyseal lines", "Lead lines in metaphyses of bones", "Transverse metaphyseal bands" ; oboInOwl:id "HP:0100959" ; a owl:Class ; rdfs:label "Dense metaphyseal bands" ; rdfs:subClassOf obo:HP_0000944 . obo:HP_0100960 obo:IAO_0000115 "Abnormal difference in size between the left and right lateral cerebral ventricles." ; dcterms:creator ; oboInOwl:creation_date "2012-01-18T05:47:26Z" ; oboInOwl:hasDbXref "UMLS:C4021909" ; oboInOwl:hasExactSynonym "Asymmetric lateral ventricles", "Asymmetric ventricles", "Cerebral lateral ventricular asymmetry" ; oboInOwl:id "HP:0100960" ; a owl:Class ; rdfs:label "Lateral ventricular asymmetry" ; rdfs:subClassOf obo:HP_0002118 . obo:HP_0100961 obo:IAO_0000115 "Increase in size of the hippocampus." ; dcterms:creator ; oboInOwl:creation_date "2012-01-18T06:05:24Z" ; oboInOwl:hasDbXref "UMLS:C4021908" ; oboInOwl:id "HP:0100961" ; a owl:Class ; rdfs:comment "The hippocampus is part of the limbic system and plays a role in long- and short-term memory." ; rdfs:label "Enlarged hippocampus" ; rdfs:subClassOf obo:HP_0025100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000586 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0100962 dcterms:creator ; oboInOwl:creation_date "2012-01-18T06:06:28Z" ; oboInOwl:hasDbXref "MSH:D012792", "UMLS:C0037020" ; oboInOwl:hasExactSynonym "Shyness" ; oboInOwl:id "HP:0100962" ; a owl:Class ; rdfs:label "Shyness" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_0100963 obo:IAO_0000115 "Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain." ; dcterms:creator ; oboInOwl:creation_date "2012-01-18T06:11:19Z" ; oboInOwl:hasDbXref "MSH:D006941", "SNOMEDCT_US:14151009", "UMLS:C0020453" ; oboInOwl:hasExactSynonym "Hyperaesthesia" ; oboInOwl:id "HP:0100963" ; a owl:Class ; rdfs:comment "Hyperesthesia is a common symptom of neuropathic pain. Neuropathic pain is defined by the International Association for the Study of Pain as pain caused by a lesion or disease of the somatosensory system. The neuropathic pain phenotype contains a spectrum of symptoms that can be roughly categorized into positive and negative symptoms. Hyperesthesia is a positive symptom of neuropathic pain. Positive symptoms are categorized as stimulus-dependent pain, stimulus-independent pain, and paresthesias." ; rdfs:label "Hyperesthesia" ; rdfs:subClassOf obo:HP_0033747 . obo:HP_0200000 obo:IAO_0000115 "Different levels of maturation of different bones." ; dcterms:creator ; oboInOwl:creation_date "2010-05-31T01:16:51Z" ; oboInOwl:hasDbXref "UMLS:C4020918" ; oboInOwl:hasExactSynonym "Dysharmonic skeletal maturation" ; oboInOwl:id "HP:0200000" ; a owl:Class ; rdfs:comment """Bone age is usually determined by using a radiograph of the left hand to compare with images in the Greulich-Pyle atlas and approximating the closest skeletal age. If the skeletal ages of individuals bones are different, i.e., different bones have (clearly) different levels of maturation, then it is referred to as dysharmonic skeletal maturation.""" ; rdfs:label "Dysharmonic bone age" ; rdfs:subClassOf obo:HP_0000927 . obo:HP_0200001 obo:IAO_0000115 "A type of dysharmonic skeletal maturation in which there is an acceleration in skeletal maturation whose degree differs markedly in different bones." ; dcterms:creator ; oboInOwl:creation_date "2010-05-31T01:20:58Z" ; oboInOwl:hasDbXref "UMLS:C4021907" ; oboInOwl:id "HP:0200001" ; a owl:Class ; rdfs:label "Dysharmonic accelerated bone age" ; rdfs:subClassOf obo:HP_0005616, obo:HP_0200000 . obo:HP_0200003 obo:IAO_0000115 "Flaring (widening) of the epiphysis." ; dcterms:creator ; oboInOwl:creation_date "2010-05-31T02:19:45Z" ; oboInOwl:hasAlternativeId "HP:0004978" ; oboInOwl:hasDbXref "UMLS:C4021906" ; oboInOwl:hasExactSynonym "Splayed end part of bone" ; oboInOwl:id "HP:0200003" ; a owl:Class ; rdfs:label "Splayed epiphyses" ; rdfs:subClassOf obo:HP_0005930 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200005 obo:IAO_0000115 "The presence of an abnormal shape of the palpebral fissure." ; dcterms:creator ; oboInOwl:creation_date "2010-06-09T07:56:37Z" ; oboInOwl:hasDbXref "UMLS:C4021905" ; oboInOwl:hasExactSynonym "Abnormal morphology of the palpebral fissure", "Abnormal shape of the opening between the eyelids" ; oboInOwl:id "HP:0200005" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Abnormal shape of the palpebral fissure" ; rdfs:subClassOf obo:HP_0008050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000052 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200006 dcterms:creator ; oboInOwl:creation_date "2010-06-09T07:57:10Z" ; oboInOwl:hasDbXref "UMLS:C2748932" ; oboInOwl:hasExactSynonym "Slanting of the opening between the eyelids" ; oboInOwl:id "HP:0200006" ; a owl:Class ; rdfs:label "Slanting of the palpebral fissure" ; rdfs:subClassOf obo:HP_0008050 . obo:HP_0200007 obo:IAO_0000115 "An abnormal size of the palpebral fissures for example unusually long or short palpebral fissures." ; dcterms:creator ; oboInOwl:creation_date "2010-06-09T08:18:52Z" ; oboInOwl:hasDbXref "UMLS:C4021904", "UMLS:C4280286" ; oboInOwl:hasExactSynonym "Abnormal size of the opening between the eyelids" ; oboInOwl:hasRelatedSynonym "Abnormal size of the eyes" ; oboInOwl:id "HP:0200007" ; a owl:Class ; rdfs:label "Abnormal size of the palpebral fissures" ; rdfs:subClassOf obo:HP_0008050 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200008 obo:IAO_0000115 "The presence of multiple polyps in the intestine." ; dcterms:creator ; oboInOwl:creation_date "2010-06-09T11:38:54Z" ; oboInOwl:hasBroadSynonym "Growths in inner lining of intestine" ; oboInOwl:hasDbXref "MSH:D044483", "UMLS:C0744333", "UMLS:C1257915" ; oboInOwl:hasExactSynonym "Multiple intestinal polyps" ; oboInOwl:hasRelatedSynonym "Gastrointestinal polyps" ; oboInOwl:id "HP:0200008" ; a owl:Class ; rdfs:label "Intestinal polyposis" ; rdfs:subClassOf obo:HP_0005266 . obo:HP_0200011 dcterms:creator ; oboInOwl:creation_date "2010-06-09T11:52:00Z" ; oboInOwl:hasDbXref "UMLS:C4021903" ; oboInOwl:id "HP:0200011" ; a owl:Class ; rdfs:label "Abnormal length of corpus callosum" ; rdfs:subClassOf obo:HP_0001273 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200012 dcterms:creator ; oboInOwl:creation_date "2010-06-09T11:52:21Z" ; oboInOwl:hasDbXref "UMLS:C4021902" ; oboInOwl:id "HP:0200012" ; a owl:Class ; rdfs:label "Short corpus callosum" ; rdfs:subClassOf obo:HP_0200011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002336 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200013 obo:IAO_0000115 "A tumor (abnormal growth of tissue) of adipose tissue." ; dcterms:creator ; oboInOwl:creation_date "2010-06-10T09:37:17Z" ; oboInOwl:hasDbXref "NCIT:C3262", "UMLS:C4021901" ; oboInOwl:hasExactSynonym "Tumor of fatty tissue", "Tumour of fatty tissue" ; oboInOwl:id "HP:0200013" ; a owl:Class ; rdfs:label "Neoplasm of fatty tissue" ; rdfs:subClassOf obo:HP_0009124, obo:HP_0011793 . obo:HP_0200015 dcterms:creator ; oboInOwl:creation_date "2010-06-16T11:57:43Z" ; oboInOwl:hasDbXref "UMLS:C4021900" ; oboInOwl:id "HP:0200015" ; a owl:Class ; rdfs:label "Symmetric great toe depigmentation" ; rdfs:subClassOf obo:HP_0001000 . obo:HP_0200016 obo:IAO_0000115 "Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T12:18:42Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:46629009", "UMLS:C0001202" ; oboInOwl:hasExactSynonym "Acral keratosis" ; oboInOwl:id "HP:0200016" ; a owl:Class ; rdfs:label "Acrokeratosis" ; rdfs:subClassOf obo:HP_0011368, obo:HP_0200036 . obo:HP_0200017 obo:IAO_0000115 "Congenital defect with failure of the development of the cerebral white matter." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T12:37:37Z" ; oboInOwl:hasDbXref "UMLS:C1859969" ; oboInOwl:hasExactSynonym "Agenesis of the cerebral white matter", "White matter agenesis" ; oboInOwl:id "HP:0200017" ; a owl:Class ; rdfs:label "Cerebral white matter agenesis" ; rdfs:subClassOf obo:HP_0012429 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002437 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200018 obo:IAO_0000115 "A type of anomalous trichromacy associated with defective long-wavelength-sensitive (L) cones, causing the sensitivity spectrum to be shifted toward medium wavelengths. This leads to difficulties especially in distinguishing red and green." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T12:55:24Z" ; oboInOwl:hasAlternativeId "HP:0200019" ; oboInOwl:hasDbXref "MSH:D003117", "SNOMEDCT_US:51445007", "UMLS:C0155015", "UMLS:C3887980" ; oboInOwl:hasExactSynonym "Colorblindness, partial, protan series", "Red-weak" ; oboInOwl:id "HP:0200018" ; a owl:Class ; rdfs:comment "Note that protanomaly and deuteranomaly are both associated with difficulties distinguishing red and green." ; rdfs:label "Protanomaly" ; rdfs:subClassOf obo:HP_0000642, obo:HP_0011519 . obo:HP_0200020 obo:IAO_0000115 "An erosion or abrasion of the cornea's outermost layer of epithelial cells." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T01:50:48Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:50792001", "UMLS:C0392163" ; oboInOwl:hasExactSynonym "Damage to outer layer of the cornea of the eye" ; oboInOwl:id "HP:0200020" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Corneal erosion" ; rdfs:subClassOf obo:HP_0011495 . obo:HP_0200021 obo:IAO_0000115 "Low set, steeply sloping shoulders." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T02:15:20Z" ; oboInOwl:hasAlternativeId "HP:0001556", "HP:0006663" ; oboInOwl:hasDbXref "UMLS:C1856872" ; oboInOwl:hasExactSynonym "Down-sloping shoulders", "Rounded shoulders", "Rounded, sloping shoulders", "Sloping shoulders" ; oboInOwl:id "HP:0200021" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Down-sloping shoulders" ; rdfs:subClassOf obo:HP_0003043 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002143 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200022 obo:IAO_0000115 "Choroid plexus papilloma is a histologically benign neoplasm located in the ventricular system of the choroid plexus." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T04:01:24Z" ; oboInOwl:hasDbXref "MSH:D020288", "NCIT:C3698", "SNOMEDCT_US:18021007", "UMLS:C0205770" ; oboInOwl:id "HP:0200022" ; a owl:Class ; rdfs:label "Choroid plexus papilloma" ; rdfs:subClassOf obo:HP_0007376, obo:HP_0012740, obo:HP_0100835 . obo:HP_0200023 obo:IAO_0000115 "A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T05:00:44Z" ; oboInOwl:hasDbXref "MSH:D011317", "SNOMEDCT_US:6273006", "UMLS:C0033117" ; oboInOwl:hasExactSynonym "hulseyism" ; oboInOwl:id "HP:0200023" ; a owl:Class ; rdfs:label "Priapism" ; rdfs:subClassOf obo:HP_0100639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000498 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0043084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200024 obo:IAO_0000115 "The presence of premature sister chromatid segregation." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T05:13:30Z" ; oboInOwl:hasDbXref "UMLS:C4021899" ; oboInOwl:id "HP:0200024" ; a owl:Class ; rdfs:label "Premature chromatid separation" ; rdfs:subClassOf obo:HP_0002916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000694 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0000819 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200025 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T07:33:14Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:274667000", "UMLS:C0236000" ; oboInOwl:hasExactSynonym "Lower jaw pain" ; oboInOwl:id "HP:0200025" ; a owl:Class ; rdfs:label "Mandibular pain" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0012531 . obo:HP_0200026 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye." ; dcterms:creator ; oboInOwl:creation_date "2010-06-16T07:39:04Z" ; oboInOwl:hasDbXref "MSH:D058447", "SNOMEDCT_US:41652007", "UMLS:C0151827" ; oboInOwl:hasExactSynonym "Eye pain" ; oboInOwl:id "HP:0200026" ; a owl:Class ; rdfs:label "Ocular pain" ; rdfs:subClassOf obo:HP_0012373, obo:HP_0046506 . obo:HP_0200028 obo:IAO_0000115 "A diffuse, non-pitting edema and thickening of the skin usually on the anterior aspect of the lower legs spreading to the dorsum of the feet." ; dcterms:creator ; oboInOwl:creation_date "2010-06-17T02:32:36Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:237825005", "SNOMEDCT_US:78146007", "UMLS:C0033103", "UMLS:C0342554" ; oboInOwl:hasExactSynonym "Graves dermopathy" ; oboInOwl:id "HP:0200028" ; a owl:Class ; rdfs:label "Pretibial myxedema" ; rdfs:subClassOf obo:HP_0011356 . obo:HP_0200029 obo:IAO_0000115 "A type of vasculitis (inflammation of blood vessel walls) that affects skeletal muscle tissue." ; dcterms:creator ; oboInOwl:creation_date "2010-06-17T02:55:19Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:53312001", "UMLS:C0262988" ; oboInOwl:hasExactSynonym "Cutaneous vasculitis" ; oboInOwl:id "HP:0200029" ; a owl:Class ; rdfs:label "Vasculitis in the skin" ; rdfs:subClassOf obo:HP_0011276, obo:HP_0034784 . obo:HP_0200030 dcterms:creator ; oboInOwl:creation_date "2010-06-17T02:55:38Z" ; oboInOwl:hasDbXref "UMLS:C3277693" ; oboInOwl:id "HP:0200030" ; a owl:Class ; rdfs:label "Punctate vasculitis skin lesions" ; rdfs:subClassOf obo:HP_0200029 . obo:HP_0200032 obo:IAO_0000115 "Grey-green or brownish-pigmented ring in the deep epithelial layers at the outer border of the cornea." ; dcterms:creator ; oboInOwl:creation_date "2010-06-24T12:30:24Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:77103006", "UMLS:C0152457" ; oboInOwl:hasExactSynonym "Fleischer's ring", "Fleischer-Kayser ring", "Fleischer-Struempell ring" ; oboInOwl:id "HP:0200032" ; a owl:Class ; rdfs:label "Kayser-Fleischer ring" ; rdfs:subClassOf obo:HP_0007957 . obo:HP_0200034 obo:IAO_0000115 "A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T01:38:03Z" ; oboInOwl:hasDbXref "MEDDRA:10033733", "SNOMEDCT_US:25694009", "SNOMEDCT_US:443871003", "UMLS:C0332563" ; oboInOwl:hasExactSynonym "Papules" ; oboInOwl:hasRelatedSynonym "Skin papules" ; oboInOwl:id "HP:0200034" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Papule" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200035 obo:IAO_0000115 "A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T01:39:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:128177006", "SNOMEDCT_US:276322001", "UMLS:C0241148" ; oboInOwl:id "HP:0200035" ; a owl:Class ; rdfs:label "Skin plaque" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200036 obo:IAO_0000115 "Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T01:48:50Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:95319004", "UMLS:C0037287" ; oboInOwl:hasExactSynonym "Growth of abnormal tissue on or under the skin" ; oboInOwl:id "HP:0200036" ; a owl:Class ; rdfs:comment "A nodule is a palpable, solid, round lesion in the deep skin or subcuteaneous tissues that is larger and deeper than a papule. Nodules are solid circumscribed masses. A common definition is that a skin nodule has a diameter of more than 5 mm in infants and more than 10 mm in older children." ; rdfs:label "Skin nodule" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200037 obo:IAO_0000115 "A circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T01:58:15Z" ; oboInOwl:hasDbXref "UMLS:C3814530" ; oboInOwl:id "HP:0200037" ; a owl:Class ; rdfs:label "Skin vesicle" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200039 obo:IAO_0000115 "A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T02:03:24Z" ; oboInOwl:hasDbXref "MEDDRA:10037578", "SNOMEDCT_US:103605005", "SNOMEDCT_US:271760008", "SNOMEDCT_US:285305004", "SNOMEDCT_US:47002008", "UMLS:C0241157", "UMLS:C0542346" ; oboInOwl:hasExactSynonym "Pimple", "Pustula", "Pustular lesion", "Pustules", "Skin pustule", "Skin pustules" ; oboInOwl:id "HP:0200039" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Pustule" ; rdfs:subClassOf obo:HP_0011123 . obo:HP_0200040 obo:IAO_0000115 "Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T02:08:02Z" ; oboInOwl:hasDbXref "MSH:D004814", "SNOMEDCT_US:399999000", "SNOMEDCT_US:417992006", "SNOMEDCT_US:418323001", "SNOMEDCT_US:418630001", "SNOMEDCT_US:419603000", "SNOMEDCT_US:419670003", "SNOMEDCT_US:419893006", "UMLS:C0014511" ; oboInOwl:hasExactSynonym "Epidermal cyst", "Epidermal inclusion cyst", "Infundibular cyst", "Keratin cyst", "Skin cyst" ; oboInOwl:hasRelatedSynonym "Epidermoid cysts", "Sebaceous cyst" ; oboInOwl:id "HP:0200040" ; a owl:Class ; rdfs:comment "A cyst is a cavity containing liquid, semisolid, or solid material. An epidermoid cyst is a benign cyst that develops out of ectodermal tissue and consists of a thin layer of squamous epithelium. An epidermal cyst may or may not be painful or release pus, and are usually noticed as a bump on the skin. Epidermal cysts and trichilemmal cysts are clinically indistinguishable. The wall of the epidermal cyst conserves the epidermal layers, but the wall of the trichilemmal cysts, which arise from the external root sheath, shows palisading of unlayered epithelial cells. Homogeneous horny material that is further degraded to fat and cholesterol forms within both types of cysts." ; rdfs:label "Epidermoid cyst" ; rdfs:subClassOf obo:HP_0025245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_62 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200041 obo:IAO_0000115 "A discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T02:15:51Z" ; oboInOwl:hasDbXref "MEDDRA:10040840", "SNOMEDCT_US:93448009", "UMLS:C3887524" ; oboInOwl:id "HP:0200041" ; a owl:Class ; rdfs:label "Skin erosion" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200042 obo:IAO_0000115 "A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T02:17:00Z" ; oboInOwl:hasDbXref "MEDDRA:10040943", "MSH:D012883", "SNOMEDCT_US:46742003", "UMLS:C0037299" ; oboInOwl:hasExactSynonym "Open skin sore" ; oboInOwl:id "HP:0200042" ; oboInOwl:inSubset hp:hposlim_core ; a owl:Class ; rdfs:label "Skin ulcer" ; rdfs:subClassOf obo:HP_0011355 . obo:HP_0200043 obo:IAO_0000115 "Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T11:35:25Z" ; oboInOwl:hasDbXref "MSH:D014860", "SNOMEDCT_US:30285000", "SNOMEDCT_US:57019003", "UMLS:C3665596" ; oboInOwl:hasExactSynonym "Warts" ; oboInOwl:id "HP:0200043" ; a owl:Class ; rdfs:comment "Cause is a virus called HPV (human papilloma virus), which infects the skin and causes the abnormal growth. There are many different varieties of the virus, which usually depends on the location of the lesion." ; rdfs:label "Verrucae" ; rdfs:subClassOf obo:HP_0012740 . obo:HP_0200044 obo:IAO_0000115 "A clonal disorder of keratinization with one or multiple atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella." ; dcterms:creator ; oboInOwl:creation_date "2010-06-18T11:57:47Z" ; oboInOwl:hasDbXref "MSH:D017499", "SNOMEDCT_US:80432009", "UMLS:C0949506" ; oboInOwl:id "HP:0200044" ; a owl:Class ; rdfs:label "Porokeratosis" ; rdfs:subClassOf obo:HP_0011368 . obo:HP_0200046 obo:IAO_0000115 "The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten." ; dcterms:creator ; oboInOwl:creation_date "2011-02-02T01:56:20Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:42712003", "UMLS:C0234861" ; oboInOwl:hasExactSynonym "Cat cry", "cat-like cry" ; oboInOwl:hasRelatedSynonym "cri de chat-associated cry" ; oboInOwl:id "HP:0200046" ; a owl:Class ; rdfs:comment "This unusual cry is characteristic of the cri du chat syndrome which results from a deletion on the p arm of chromosome 5. It is thought to be due to laryngeal hypoplasia, floppy epiglottis, small larynx, and asymmetric vocal cords, but is probably also related to dysfunction of the central nervous system. This sign occurs in infants and disappears with age." ; rdfs:label "Cat cry" ; rdfs:subClassOf obo:HP_0025429 . obo:HP_0200047 obo:IAO_0000115 "Inflammation of the cartilage of the external ear." ; dcterms:creator ; oboInOwl:creation_date "2011-02-02T02:02:10Z" ; oboInOwl:hasDbXref "UMLS:C0741305" ; oboInOwl:hasExactSynonym "Inflammation of cartilage of pinna" ; oboInOwl:id "HP:0200047" ; a owl:Class ; rdfs:label "Chondritis of pinna" ; rdfs:subClassOf obo:HP_0000377, obo:HP_0100662 . obo:HP_0200048 dcterms:creator ; oboInOwl:creation_date "2011-02-02T02:03:18Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:301795004", "UMLS:C0578475" ; oboInOwl:id "HP:0200048" ; a owl:Class ; rdfs:label "Cyanotic episode" ; rdfs:subClassOf obo:HP_0000961 . obo:HP_0200049 obo:IAO_0000115 "Increased muscle tone observed in the arms of the affected person." ; dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021898" ; oboInOwl:id "HP:0200049" ; a owl:Class ; rdfs:label "Upper limb hypertonia" ; rdfs:subClassOf obo:HP_0001446, obo:HP_0002509 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001618 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001499 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200050 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C4021897" ; oboInOwl:hasExactSynonym "Bracket shaped end part of long bone of hand" ; oboInOwl:id "HP:0200050" ; a owl:Class ; rdfs:label "Bracket metacarpal epiphyses" ; rdfs:subClassOf obo:HP_0005913 . obo:HP_0200053 obo:IAO_0000115 "Shortening of a leg affecting only one side." ; dcterms:creator ; oboInOwl:creation_date "2011-12-02T03:41:26Z" ; oboInOwl:hasAlternativeId "HP:0005618" ; oboInOwl:hasDbXref "UMLS:C1844734" ; oboInOwl:hasExactSynonym "Asymmetric leg shortening", "Asymmetric lower limb shortness" ; oboInOwl:id "HP:0200053" ; a owl:Class ; rdfs:label "Hemihypotrophy of lower limb" ; rdfs:subClassOf obo:HP_0100556 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000978 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000616 ] ) ] ] . obo:HP_0200054 dcterms:creator ; oboInOwl:creation_date "2011-11-22T09:56:55Z" ; oboInOwl:hasDbXref "UMLS:C4021896" ; oboInOwl:id "HP:0200054" ; a owl:Class ; rdfs:label "Foot monodactyly" ; rdfs:subClassOf obo:HP_0001849 . obo:HP_0200055 obo:IAO_0000115 "Disproportionately small hand." ; dcterms:creator ; oboInOwl:hasDbXref "SNOMEDCT_US:299032009", "UMLS:C0575802" ; oboInOwl:hasExactSynonym "Disproportionately small hands", "Small hand" ; oboInOwl:hasRelatedSynonym "Small hands" ; oboInOwl:id "HP:0200055" ; a owl:Class ; rdfs:label "Small hand" ; rdfs:subClassOf obo:HP_0005927 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000587 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200056 obo:IAO_0000115 "Scar tissue in the macula." ; dcterms:creator ; oboInOwl:creation_date "2012-11-18T11:09:09Z" ; oboInOwl:hasAlternativeId "HP:0007949" ; oboInOwl:hasDbXref "SNOMEDCT_US:18410006", "UMLS:C0423428" ; oboInOwl:hasExactSynonym "Macular scarring" ; oboInOwl:id "HP:0200056" ; a owl:Class ; rdfs:label "Macular scar" ; rdfs:subClassOf obo:HP_0007401, obo:HP_0100699 . obo:HP_0200057 obo:IAO_0000115 "An aberrant pupillary response characterized by (i) Constriction of pupils of both eyes when the light stimulus is applied to the normal eye, and (ii) Dilatation of pupils of both eyes when the light stimulus is rapidly transferred from the normal eye (after brief light exposure to the normal eye) to the affected eye." ; dcterms:creator ; oboInOwl:creation_date "2012-11-18T12:14:22Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:232122003", "SNOMEDCT_US:247015002", "UMLS:C0549122" ; oboInOwl:hasExactSynonym "Relative afferent pupil defect", "Relative afferent pupillary defect" ; oboInOwl:id "HP:0200057" ; a owl:Class ; rdfs:label "Marcus Gunn pupil" ; rdfs:subClassOf obo:HP_0000587 . obo:HP_0200058 dcterms:creator ; oboInOwl:hasDbXref "MSH:D006394", "SNOMEDCT_US:33176006", "SNOMEDCT_US:39000009", "SNOMEDCT_US:403977003", "UMLS:C0018923" ; oboInOwl:id "HP:0200058" ; a owl:Class ; rdfs:label "Angiosarcoma" ; rdfs:subClassOf obo:HP_0030448 . obo:HP_0200059 dcterms:creator ; oboInOwl:hasDbXref "UMLS:C0854892" ; oboInOwl:id "HP:0200059" ; a owl:Class ; rdfs:label "Metastatic angiosarcoma" ; rdfs:subClassOf obo:HP_0200058 . obo:HP_0200063 obo:IAO_0000115 "Multiple abnormal growths that arise from the lining of the large intestine (colon or rectum) and protrude into the intestinal lumen." ; dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:19:31Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:399505005", "UMLS:C0949059" ; oboInOwl:hasExactSynonym "Colorectal polyps" ; oboInOwl:id "HP:0200063" ; a owl:Class ; rdfs:label "Colorectal polyposis" ; rdfs:subClassOf obo:HP_0030255, obo:HP_0100743 . obo:HP_0200064 obo:IAO_0000115 "Asymmetry between the two irides or asymmetry between different parts of one iris." ; dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:27:41Z" ; oboInOwl:hasDbXref "MSH:C538115", "SNOMEDCT_US:247033008", "UMLS:C0423318" ; oboInOwl:id "HP:0200064" ; a owl:Class ; rdfs:label "Asymmetry of iris pigmentation" ; rdfs:subClassOf obo:HP_0008034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200065 dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:29:16Z" ; oboInOwl:hasAlternativeId "HP:0007912", "HP:0007945" ; oboInOwl:hasDbXref "SNOMEDCT_US:247177004", "UMLS:C0521683" ; oboInOwl:id "HP:0200065" ; a owl:Class ; rdfs:label "Chorioretinal degeneration" ; rdfs:subClassOf obo:HP_0000532 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf ([ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000966 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001776 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] ) ] . obo:HP_0200066 dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:31:04Z" ; oboInOwl:hasDbXref "UMLS:C4021894" ; oboInOwl:id "HP:0200066" ; a owl:Class ; rdfs:label "Ribbonlike corneal degeneration" ; rdfs:subClassOf obo:HP_0007705 . obo:HP_0200067 obo:IAO_0000115 "Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference." ; dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:33:01Z" ; oboInOwl:hasDbXref "UMLS:C3279439" ; oboInOwl:hasRelatedSynonym "Spontaneous abortion, recurrent" ; oboInOwl:id "HP:0200067" ; a owl:Class ; rdfs:label "Recurrent spontaneous abortion" ; rdfs:subClassOf obo:HP_0002686 . obo:HP_0200068 dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:36:51Z" ; oboInOwl:hasDbXref "UMLS:C3553696", "UMLS:C4021893" ; oboInOwl:hasRelatedSynonym "Decreased visual acuity, nonprogressive" ; oboInOwl:id "HP:0200068" ; a owl:Class ; rdfs:label "Nonprogressive visual loss" ; rdfs:subClassOf obo:HP_0000572 . obo:HP_0200070 dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:48:09Z" ; oboInOwl:hasDbXref "UMLS:C3553016" ; oboInOwl:hasExactSynonym "Wasting of the outer part of the retina" ; oboInOwl:id "HP:0200070" ; a owl:Class ; rdfs:label "Peripheral retinal atrophy" ; rdfs:subClassOf obo:HP_0001105 . obo:HP_0200071 obo:IAO_0000115 "A type of vitreoretinal degeneration with manifestations that are concentrated at the periphery of the retina." ; dcterms:creator ; oboInOwl:creation_date "2013-05-31T01:49:02Z" ; oboInOwl:hasDbXref "UMLS:C3280349" ; oboInOwl:id "HP:0200071" ; a owl:Class ; rdfs:label "Peripheral vitreoretinal degeneration" ; rdfs:subClassOf obo:HP_0007773 . obo:HP_0200072 obo:IAO_0000115 "Intermittent episodes of paralysis of all four limbs." ; dcterms:creator ; oboInOwl:creation_date "2013-05-31T04:27:32Z" ; oboInOwl:hasDbXref "UMLS:C1863062" ; oboInOwl:hasRelatedSynonym "Quadriplegia, episodic" ; oboInOwl:id "HP:0200072" ; a owl:Class ; rdfs:label "Episodic quadriplegia" ; rdfs:subClassOf obo:HP_0002445 . obo:HP_0200073 dcterms:creator ; oboInOwl:creation_date "2013-05-31T04:31:32Z" ; oboInOwl:hasDbXref "UMLS:C3552099" ; oboInOwl:id "HP:0200073" ; a owl:Class ; rdfs:label "Respiratory insufficiency due to defective ciliary clearance" ; rdfs:subClassOf obo:HP_0002093, obo:HP_0012261 . obo:HP_0200083 dcterms:creator ; oboInOwl:creation_date "2013-06-03T04:14:07Z" ; oboInOwl:hasDbXref "UMLS:C1835446" ; oboInOwl:hasExactSynonym "Severe limb shortening" ; oboInOwl:id "HP:0200083" ; a owl:Class ; rdfs:label "Severe limb shortening" ; rdfs:subClassOf obo:HP_0002983 . obo:HP_0200084 obo:IAO_0000115 "Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver." ; dcterms:creator ; oboInOwl:creation_date "2013-06-04T02:32:26Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:69800000", "UMLS:C0027613", "UMLS:C2673820", "UMLS:C2675624", "UMLS:C4020697" ; oboInOwl:hasRelatedSynonym "Giant cell hepatitis on biopsy", "Giant cell hepatitis on liver biopsy", "Giant cell hepatitis shown on biopsy" ; oboInOwl:id "HP:0200084" ; a owl:Class ; rdfs:label "Giant cell hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0200085 dcterms:creator ; oboInOwl:creation_date "2013-06-04T02:39:15Z" ; oboInOwl:hasDbXref "MSH:D014202", "UMLS:C0235081" ; oboInOwl:hasExactSynonym "Involuntary shaking of limb", "Limb tremor" ; oboInOwl:hasRelatedSynonym "Tremor of limbs" ; oboInOwl:id "HP:0200085" ; a owl:Class ; rdfs:label "Limb tremor" ; rdfs:subClassOf obo:HP_0030188 . obo:HP_0200094 dcterms:creator ; oboInOwl:creation_date "2013-06-04T03:04:44Z" ; oboInOwl:hasDbXref "UMLS:C1857012" ; oboInOwl:id "HP:0200094" ; a owl:Class ; rdfs:label "Frontal open bite" ; rdfs:subClassOf obo:HP_0010807 . obo:HP_0200095 obo:IAO_0100001 "HP:0009102" ; dcterms:creator ; oboInOwl:creation_date "2013-06-04T03:04:56Z" ; oboInOwl:id "HP:0200095" ; a owl:Class ; rdfs:label "obsolete Anterior open bite" ; owl:deprecated true . obo:HP_0200096 obo:IAO_0000115 "A facial appearance characterized by a permanently or nearly permanently opened mouth, in which the upper lip is tented in a way that the opened mouth has the appearance of a triangle." ; dcterms:creator ; oboInOwl:creation_date "2013-06-04T03:06:03Z" ; oboInOwl:hasDbXref "UMLS:C1859292" ; oboInOwl:hasExactSynonym "Triangular-shaped open mouth" ; oboInOwl:id "HP:0200096" ; a owl:Class ; rdfs:label "Triangular-shaped open mouth" ; rdfs:subClassOf obo:HP_0000194, obo:HP_0000207 . obo:HP_0200097 obo:IAO_0000115 "Blisters arising in the mouth." ; dcterms:creator ; oboInOwl:creation_date "2013-06-05T09:59:58Z" ; oboInOwl:hasDbXref "UMLS:C0853945" ; oboInOwl:hasExactSynonym "Blebs of oral mucosa", "Blisters of mouth", "Bullae of oral mucosa", "Oral blistering", "Oral mucosal blisters" ; oboInOwl:hasRelatedSynonym "Oral mucosa blisters" ; oboInOwl:id "HP:0200097" ; a owl:Class ; rdfs:label "Oral mucosal blisters" ; rdfs:subClassOf obo:HP_0011830, obo:HP_0033800 . obo:HP_0200098 obo:IAO_0000115 "Lack of skin pigmentation (coloring)." ; dcterms:creator ; oboInOwl:creation_date "2013-06-05T10:22:18Z" ; oboInOwl:hasDbXref "UMLS:C2673954" ; oboInOwl:hasExactSynonym "Absent skin pigmentation", "Lack of skin coloration" ; oboInOwl:id "HP:0200098" ; a owl:Class ; rdfs:label "Absent skin pigmentation" ; rdfs:subClassOf obo:HP_0001010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200099 dcterms:creator ; oboInOwl:consider "HP:0007703" ; oboInOwl:creation_date "2013-06-05T10:24:46Z" ; oboInOwl:id "HP:0200099" ; a owl:Class ; rdfs:label "obsolete Peripheral retinal pigmentation abnormalities" ; owl:deprecated true . obo:HP_0200101 dcterms:creator ; oboInOwl:creation_date "2013-06-05T11:58:29Z" ; oboInOwl:hasDbXref "UMLS:C1850816" ; oboInOwl:hasExactSynonym "Decreased/absent ankle reflexes" ; oboInOwl:hasRelatedSynonym "Decreased or absent ankle reflexes" ; oboInOwl:id "HP:0200101" ; a owl:Class ; rdfs:label "Decreased/absent ankle reflexes" ; rdfs:subClassOf obo:HP_0002522 . obo:HP_0200102 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:03:01Z" ; oboInOwl:hasDbXref "UMLS:C1835157", "UMLS:C1862855", "UMLS:C3551431" ; oboInOwl:hasExactSynonym "Sparse or absent eyelashes" ; oboInOwl:hasRelatedSynonym "Partial to total absence of eyelashes", "Sparse to absent eyelashes" ; oboInOwl:id "HP:0200102" ; a owl:Class ; rdfs:label "Sparse or absent eyelashes" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:HP_0000561 obo:HP_0000653 ) ] ] . obo:HP_0200104 obo:IAO_0000115 "Absence of nail of little finger." ; dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:11:16Z" ; oboInOwl:hasAlternativeId "HP:0011366" ; oboInOwl:hasDbXref "UMLS:C4020917" ; oboInOwl:hasExactSynonym "Absent fifth fingernail", "Absent nail of fifth finger" ; oboInOwl:id "HP:0200104" ; a owl:Class ; rdfs:label "Absent fifth fingernail" ; rdfs:subClassOf obo:HP_0001817 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200105 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:11:38Z" ; oboInOwl:hasDbXref "UMLS:C4021892" ; oboInOwl:hasExactSynonym "Absent fifth toenail", "Missing fifth toenail" ; oboInOwl:id "HP:0200105" ; a owl:Class ; rdfs:label "Absent fifth toenail" ; rdfs:subClassOf obo:HP_0001802 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0011282 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200106 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:14:18Z" ; oboInOwl:hasDbXref "UMLS:C4021891" ; oboInOwl:id "HP:0200106" ; a owl:Class ; rdfs:label "Absent/shortened dynein arms" ; rdfs:subClassOf obo:HP_0012255 . obo:HP_0200107 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:14:49Z" ; oboInOwl:hasDbXref "UMLS:C4021890" ; oboInOwl:id "HP:0200107" ; a owl:Class ; rdfs:label "Shortened inner dynein arms" ; rdfs:subClassOf obo:HP_0200106 . obo:HP_0200108 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:15:10Z" ; oboInOwl:hasDbXref "UMLS:C4021889" ; oboInOwl:id "HP:0200108" ; a owl:Class ; rdfs:label "Shortened outer dynein arms" ; rdfs:subClassOf obo:HP_0200106 . obo:HP_0200109 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:17:14Z" ; oboInOwl:hasDbXref "UMLS:C2750161" ; oboInOwl:hasRelatedSynonym "Respiratory cilia have shortened or absent outer dynein arms" ; oboInOwl:id "HP:0200109" ; a owl:Class ; rdfs:label "Absent/shortened outer dynein arms" ; rdfs:subClassOf obo:HP_0200106 . obo:HP_0200111 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:21:37Z" ; oboInOwl:hasDbXref "UMLS:C4021888" ; oboInOwl:id "HP:0200111" ; a owl:Class ; rdfs:label "Absent stapes head" ; rdfs:subClassOf obo:HP_0008628 . obo:HP_0200113 dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:27:09Z" ; oboInOwl:hasDbXref "UMLS:C4021887" ; oboInOwl:hasRelatedSynonym "Aphalangy, hands and feet" ; oboInOwl:id "HP:0200113" ; a owl:Class ; rdfs:label "Aphalangy of hands and feet" ; rdfs:subClassOf obo:HP_0005886, obo:HP_0009776, obo:HP_0010745 . obo:HP_0200114 obo:IAO_0000115 "Metabolic alkalosis is defined as a disease state where the pH is elevated to greater than 7.45 secondary to some metabolic process." ; dcterms:creator ; oboInOwl:creation_date "2013-06-05T12:33:28Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:1388004", "UMLS:C0220983" ; oboInOwl:id "HP:0200114" ; a owl:Class ; rdfs:label "Metabolic alkalosis" ; rdfs:subClassOf obo:HP_0001948 . obo:HP_0200116 dcterms:creator ; oboInOwl:creation_date "2013-06-06T04:14:39Z" ; oboInOwl:hasDbXref "UMLS:C3279409" ; oboInOwl:id "HP:0200116" ; a owl:Class ; rdfs:label "Distal ileal atresia" ; rdfs:subClassOf obo:HP_0011102 . obo:HP_0200117 obo:IAO_0000115 "Increased susceptibility to upper and lower respiratory tract infections, as manifested by recurrent episodes of upper and lower respiratory tract infections." ; dcterms:creator ; oboInOwl:creation_date "2013-06-07T01:34:02Z" ; oboInOwl:hasDbXref "UMLS:C1842777" ; oboInOwl:id "HP:0200117" ; a owl:Class ; rdfs:label "Recurrent upper and lower respiratory tract infections" ; rdfs:subClassOf obo:HP_0002783, obo:HP_0002788 . obo:HP_0200118 dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:04:49Z" ; oboInOwl:hasDbXref "UMLS:C0750292", "UMLS:C1850013" ; oboInOwl:hasRelatedSynonym "Malabsorption of cyanocobalamin", "Vitamin B12 deficiency caused by intestinal malabsorption" ; oboInOwl:id "HP:0200118" ; a owl:Class ; rdfs:label "Malabsorption of Vitamin B12" ; rdfs:subClassOf obo:HP_0004341 . obo:HP_0200119 obo:IAO_0000115 "Acute hepatic injury resulting from inflammation typically accompanied by increased serum alanine transaminase activity. Etiologies include viral hepatitis, drugs, toxins, and autoimmune disorders." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:15:57Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:37871000", "UMLS:C0267797" ; oboInOwl:hasExactSynonym "Acute liver inflammation" ; oboInOwl:id "HP:0200119" ; a owl:Class ; rdfs:label "Acute hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0200120 obo:IAO_0000115 "Chronic hepatitis associated with recurrent clinical exacerbations, extrahepatic manifestations, and progression to cirrhosis." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:17:25Z" ; oboInOwl:hasDbXref "MSH:D006521", "SNOMEDCT_US:197284004", "UMLS:C0520463" ; oboInOwl:hasRelatedSynonym "Hepatitis, chronic active" ; oboInOwl:id "HP:0200120" ; a owl:Class ; rdfs:label "Chronic active hepatitis" ; rdfs:subClassOf obo:HP_0200123 . obo:HP_0200122 dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:20:29Z" ; oboInOwl:hasDbXref "UMLS:C1848456" ; oboInOwl:hasExactSynonym "Atypical or prolonged liver inflammation" ; oboInOwl:id "HP:0200122" ; a owl:Class ; rdfs:label "Atypical or prolonged hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0200123 obo:IAO_0000115 "Hepatitis that lasts for more than six months." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:20:53Z" ; oboInOwl:hasDbXref "MSH:D006521", "SNOMEDCT_US:76783007", "UMLS:C0019189" ; oboInOwl:hasExactSynonym "Chronic liver inflammation" ; oboInOwl:id "HP:0200123" ; a owl:Class ; rdfs:label "Chronic hepatitis" ; rdfs:subClassOf obo:HP_0012115 . obo:HP_0200124 obo:IAO_0000115 "Chronic hepatitis associated with infection by cryptosporidia, as demonstrated (for example) by immunohistochemistry of liver tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:21:21Z" ; oboInOwl:hasDbXref "UMLS:C3808820" ; oboInOwl:hasRelatedSynonym "Hepatitis, chronic, due to cryptosporidium infection" ; oboInOwl:id "HP:0200124" ; a owl:Class ; rdfs:label "Chronic hepatitis due to cryptosporidium infection" ; rdfs:subClassOf obo:HP_0200123 . obo:HP_0200125 dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:22:52Z" ; oboInOwl:hasDbXref "UMLS:C2751582" ; oboInOwl:id "HP:0200125" ; a owl:Class ; rdfs:label "Mitochondrial respiratory chain defects" ; rdfs:subClassOf obo:HP_0003287 . obo:HP_0200126 obo:IAO_0100001 "HP:0030843" ; oboInOwl:id "HP:0200126" ; a owl:Class ; rdfs:label "obsolete Amyloid cardiomyopathy" ; owl:deprecated true . obo:HP_0200127 obo:IAO_0000115 "Any complex of structural, architectural, contractile or electrophysiological changes affecting the atria with the potential to produce clinically relevant manifestations." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:27:27Z" ; oboInOwl:hasDbXref "UMLS:C4021885" ; oboInOwl:id "HP:0200127" ; a owl:Class ; rdfs:label "Atrial cardiomyopathy" ; rdfs:subClassOf obo:HP_0001638 . obo:HP_0200128 obo:IAO_0000115 "Thickening of the heart walls in both ventricles." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T11:28:46Z" ; oboInOwl:hasDbXref "UMLS:C0281788" ; oboInOwl:id "HP:0200128" ; a owl:Class ; rdfs:label "Biventricular hypertrophy" ; rdfs:subClassOf obo:HP_0001714 . obo:HP_0200129 oboInOwl:consider "HP:0001718" ; oboInOwl:id "HP:0200129" ; a owl:Class ; rdfs:label "obsolete Calcific mitral stenosis" ; owl:deprecated true . obo:HP_0200133 dcterms:creator ; oboInOwl:creation_date "2013-06-11T03:59:35Z" ; oboInOwl:hasDbXref "UMLS:C2675557" ; oboInOwl:id "HP:0200133" ; a owl:Class ; rdfs:label "Lumbosacral meningocele" ; rdfs:subClassOf obo:HP_0100712 . obo:HP_0200134 obo:IAO_0000115 "A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death." ; dcterms:creator ; oboInOwl:creation_date "2013-06-11T04:02:30Z" ; oboInOwl:hasDbXref "UMLS:C0543888" ; oboInOwl:hasExactSynonym "Convulsive encephalopathy" ; oboInOwl:id "HP:0200134" ; a owl:Class ; rdfs:comment "Seizures alone without any underlying neurologic or medical illness can be the sole cause of encephalopathy. Patients with seizures as a cause or consequence of encephalopathy present with a wide variety of neurologic symptoms from mild reduction or alteration of consciousness to coma. Findings on neurologic exam are often nonfocal, nonspecific, and not predictive of the presence of seizures. Patients may or may not have subtle motor findings accompanying the presentation of encephalopathy. Signs range from very focal findings, such as nystagmus, eye flutter, blinking, and eye deviation to more widespread signs, such as myoclonus, tremulousness, and autonomic instability." ; rdfs:label "Epileptic encephalopathy" ; rdfs:subClassOf obo:HP_0001298 . obo:HP_0200135 oboInOwl:consider "HP:0000256" ; oboInOwl:id "HP:0200135" ; a owl:Class ; rdfs:label "obsolete Macrocephaly due to hydrocephalus" ; owl:deprecated true . obo:HP_0200136 dcterms:creator ; oboInOwl:creation_date "2013-06-12T11:05:35Z" ; oboInOwl:hasDbXref "MSH:D003680", "SNOMEDCT_US:71457002", "UMLS:C0267071" ; oboInOwl:hasExactSynonym "Oral pharyngeal dysphagia", "Oropharyngeal dysphagia" ; oboInOwl:id "HP:0200136" ; a owl:Class ; rdfs:label "Oral-pharyngeal dysphagia" ; rdfs:subClassOf obo:HP_0002015 . obo:HP_0200138 dcterms:creator ; oboInOwl:creation_date "2013-06-12T11:08:52Z" ; oboInOwl:hasDbXref "UMLS:C4021884" ; oboInOwl:id "HP:0200138" ; a owl:Class ; rdfs:label "Bilateral choanal atresia/stenosis" ; rdfs:subClassOf obo:HP_0000452, obo:HP_0004502 . obo:HP_0200141 dcterms:creator ; oboInOwl:creation_date "2013-06-13T11:59:54Z" ; oboInOwl:hasDbXref "UMLS:C1851883", "UMLS:C4280284", "UMLS:C4280285" ; oboInOwl:hasExactSynonym "Conical microdontia", "Small, cone shaped teeth" ; oboInOwl:hasRelatedSynonym "Small, peg shaped teeth", "Small, pointed teeth" ; oboInOwl:id "HP:0200141" ; a owl:Class ; rdfs:label "Small, conical teeth" ; rdfs:subClassOf obo:HP_0000691, obo:HP_0000698 . obo:HP_0200143 dcterms:creator ; oboInOwl:creation_date "2013-06-13T12:44:34Z" ; oboInOwl:hasDbXref "UMLS:C1334688", "UMLS:C1850020" ; oboInOwl:hasRelatedSynonym "Bone marrow biopsy shows megaloblastic erythroid hyperplasia" ; oboInOwl:id "HP:0200143" ; a owl:Class ; rdfs:label "Megaloblastic erythroid hyperplasia" ; rdfs:subClassOf obo:HP_0012132 . obo:HP_0200144 oboInOwl:consider "HP:0000979" ; oboInOwl:id "HP:0200144" ; a owl:Class ; rdfs:label "obsolete Anaphylactoid purpura" ; owl:deprecated true . obo:HP_0200146 obo:IAO_0000115 "An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.)." ; dcterms:creator ; oboInOwl:creation_date "2013-06-13T12:55:22Z" ; oboInOwl:hasDbXref "MSH:C536230", "SNOMEDCT_US:234021009", "SNOMEDCT_US:42182000", "SNOMEDCT_US:45894003", "UMLS:C0392775" ; oboInOwl:hasExactSynonym "Cystic medial necrosis of the aorta", "MEMA" ; oboInOwl:id "HP:0200146" ; a owl:Class ; rdfs:comment "MEMA replaces a variety of terms used in the past such as cystic medial necrosis, cystonecrosis, cystic degeneration, mucoid degeneration which, while generally understood by pathologists, are inaccurate. This histopathology can be subclassified and graded according to distribution, severity, and/or whether it crosses over multiple lamellar units as described. The grading should be reported as mild/moderate/severe and the distribution should be reported as focal, multifocal, or extensive." ; rdfs:label "Mucoid extracellular matrix accumulation" ; rdfs:subClassOf obo:HP_0012180, obo:HP_0032079 . obo:HP_0200147 obo:IAO_0000115 "A reduction in the number of nerve cells in the basal ganglia." ; dcterms:creator ; oboInOwl:creation_date "2013-06-13T12:59:06Z" ; oboInOwl:hasDbXref "UMLS:C2750913" ; oboInOwl:id "HP:0200147" ; a owl:Class ; rdfs:comment "See Fig. 11 in PMID:13729575." ; rdfs:label "Neuronal loss in basal ganglia" ; rdfs:subClassOf obo:HP_0002134 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002420 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200148 dcterms:creator ; oboInOwl:creation_date "2013-06-13T01:01:21Z" ; oboInOwl:hasDbXref "UMLS:C2750654", "UMLS:C4021883" ; oboInOwl:hasExactSynonym "Abnormal liver function tests during pregnancy" ; oboInOwl:hasRelatedSynonym "Abnormal liver function tests during pregnancy, resolves postpartum" ; oboInOwl:id "HP:0200148" ; a owl:Class ; rdfs:label "Abnormal liver function tests during pregnancy" ; rdfs:subClassOf obo:HP_0002910 . obo:HP_0200149 obo:IAO_0000115 "An increased lymphocyte count in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:creation_date "2013-06-13T01:03:23Z" ; oboInOwl:hasDbXref "SNOMEDCT_US:167719009", "UMLS:C0427877" ; oboInOwl:hasExactSynonym "CSF lymphocytosis" ; oboInOwl:id "HP:0200149" ; a owl:Class ; rdfs:label "CSF lymphocytic pleiocytosis" ; rdfs:subClassOf obo:HP_0012229 . obo:HP_0200150 dcterms:creator ; oboInOwl:creation_date "2013-06-13T01:05:40Z" ; oboInOwl:hasDbXref "UMLS:C4020695", "UMLS:C4021882" ; oboInOwl:hasRelatedSynonym "Increased serum bile acid concentration during pregnancy, resolves" ; oboInOwl:id "HP:0200150" ; a owl:Class ; rdfs:label "Increased serum bile acid concentration during pregnancy" ; rdfs:subClassOf obo:HP_0012202 . obo:HP_0200151 obo:IAO_0000115 "Multifocal dense infiltrates of mast cells in cutaneous tissue." ; dcterms:creator ; oboInOwl:creation_date "2013-06-14T09:22:02Z" ; oboInOwl:hasDbXref "MSH:D034701", "SNOMEDCT_US:397012002", "SNOMEDCT_US:703827008", "UMLS:C1136033" ; oboInOwl:id "HP:0200151" ; a owl:Class ; rdfs:label "Cutaneous mastocytosis" ; rdfs:subClassOf obo:HP_0008069, obo:HP_0100495 . obo:HP_0200153 oboInOwl:hasDbXref "UMLS:C4021881", "UMLS:C4227831" ; oboInOwl:hasExactSynonym "Failure of development of lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of lateral incisor", "Missing lateral incisor" ; a owl:Class ; rdfs:label "Agenesis of lateral incisor" ; rdfs:subClassOf obo:HP_0006485 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018552 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200154 oboInOwl:hasDbXref "UMLS:C4021880", "UMLS:C4280283" ; oboInOwl:hasExactSynonym "Failure of development of mandibular lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of lower lateral incisor", "Absence of mandibular lateral incisor", "Missing lower lateral incisor", "Missing mandibular lateral incisor" ; a owl:Class ; rdfs:label "Agenesis of mandibular lateral incisor" ; rdfs:subClassOf obo:HP_0200153, obo:HP_0200161 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018602 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200158 oboInOwl:hasDbXref "UMLS:C4021879", "UMLS:C4280282" ; oboInOwl:hasExactSynonym "Failure of development of permanent mandibular lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of adult mandibular lateral incisor", "Absence of permanent mandibular lateral incisor", "Missing adult lower lateral incisor", "Missing permanent mandibular lateral incisor" ; a owl:Class ; rdfs:label "Agenesis of permanent mandibular lateral incisor" ; rdfs:subClassOf obo:HP_0200154 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018570 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200159 oboInOwl:hasDbXref "UMLS:C4021878", "UMLS:C4280280", "UMLS:C4280281" ; oboInOwl:hasExactSynonym "Agenesis of deciduous mandibular lateral incisor", "Failure of development of deciduous mandibular lateral incisor", "Failure of development of primary mandibular lateral incisor" ; oboInOwl:hasRelatedSynonym "Absence of deciduous mandibular lateral incisor", "Absence of lower front baby tooth", "Absence of primary mandibular lateral incisor", "Missing deciduous mandibular lateral incisor", "Missing primary mandibular lateral incisor" ; a owl:Class ; rdfs:label "Agenesis of primary mandibular lateral incisor" ; rdfs:subClassOf obo:HP_0200154 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0018596 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200160 oboInOwl:hasDbXref "UMLS:C4021877", "UMLS:C4280278", "UMLS:C4280279" ; oboInOwl:hasExactSynonym "Failure of development of maxillary incisor", "Failure of development of upper incisor" ; oboInOwl:hasNarrowSynonym "Absence of upper front tooth" ; oboInOwl:hasRelatedSynonym "Absence of maxillary incisor", "Missing upper front tooth", "Missing upper incisor" ; a owl:Class ; rdfs:label "Agenesis of maxillary incisor" ; rdfs:subClassOf obo:HP_0006485 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0200161 oboInOwl:hasDbXref "UMLS:C3150012", "UMLS:C4021876", "UMLS:C4280277" ; oboInOwl:hasExactSynonym "Agenesis of lower incisor", "Failure of development of mandibular incisor" ; oboInOwl:hasNarrowSynonym "Absence of lower front tooth" ; oboInOwl:hasRelatedSynonym "Absence of lower incisor", "Absence of mandibular incisor", "Missing lower front tooth", "Missing lower incisor" ; a owl:Class ; rdfs:label "Agenesis of mandibular incisor" ; rdfs:subClassOf obo:HP_0006485 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002291 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0400000 obo:IAO_0000115 "Increased vertical distance from the vermillion border of the lower lip to the inferior-most point of the chin." ; oboInOwl:hasDbXref "SNOMEDCT_US:471397004", "UMLS:C3532221", "UMLS:C4021875" ; oboInOwl:hasExactSynonym "Increased height of chin", "Increased height of menton region", "Long chin", "Tall chin", "Vertical excess of chin", "Vertical hyperplasia of chin" ; oboInOwl:hasRelatedSynonym "Long lower third of face" ; a owl:Class ; rdfs:label "Tall chin" ; rdfs:subClassOf obo:HP_0000306 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0400001 obo:IAO_0000115 "Vertical crease fold situated below the vermilion border of the lower lip and above the fatty pad of the chin with the face at rest." ; oboInOwl:hasDbXref "UMLS:C4020916" ; oboInOwl:hasExactSynonym "Chin with vertical crease", "Chin with vertical furrow", "Chin with vertical groove", "Chin with vertical sulcus", "Chin, vertical crease", "Cleft chin", "Vertical chin skin cleft", "Vertical menton crease" ; a owl:Class ; rdfs:comment "The vertical shape must be distinguished from H-shaped crease of the chin." ; rdfs:label "Chin with vertical crease" ; rdfs:subClassOf obo:HP_0000306 . obo:HP_0400002 obo:IAO_0000115 "Folds or ridges within the concha that are distinct from the crus helix." ; oboInOwl:hasDbXref "UMLS:C4020915" ; oboInOwl:hasExactSynonym "Concha, Extra Fold" ; a owl:Class ; rdfs:label "Extra concha fold" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001910 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006203 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0400003 obo:IAO_0000115 "Absence of a localized portion of the ear that cannot be described by a more precise term (e.g., absent ear lobe)." ; oboInOwl:hasDbXref "UMLS:C4021874" ; a owl:Class ; rdfs:label "Focal absence of the external ear" ; rdfs:subClassOf obo:HP_0008772 . obo:HP_0400004 obo:IAO_0000115 "Median longitudinal ear length greater than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear." ; oboInOwl:hasDbXref "UMLS:C1848657" ; oboInOwl:hasExactSynonym "Long ear", "Long ears" ; a owl:Class ; rdfs:comment "The commonly used term Macrotia is a bundled term comprising increased length and width (surface area)." ; rdfs:label "Long ear" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000573 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0400005 obo:IAO_0000115 "Median longitudinal ear length less than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear." ; oboInOwl:hasDbXref "UMLS:C3551041" ; oboInOwl:hasExactSynonym "Short ear", "Short ears" ; a owl:Class ; rdfs:comment "The commonly used term Microtia is a bundled term comprising decreased length and width (surface area)." ; rdfs:label "Short ear" ; rdfs:subClassOf obo:HP_0000377 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000574 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0400007 obo:IAO_0000115 "Frequent menses; menstrual cycles lasting less than 21 days." ; oboInOwl:hasDbXref "MSH:D008599", "SNOMEDCT_US:52754008", "UMLS:C0032519" ; a owl:Class ; rdfs:label "Polymenorrhea" ; rdfs:subClassOf obo:HP_0000140 . obo:HP_0400008 obo:IAO_0000115 "Prolonged/excessive menses and bleeding at irregular intervals." ; oboInOwl:hasDbXref "SNOMEDCT_US:314631008", "SNOMEDCT_US:351814001", "UMLS:C0232943" ; a owl:Class ; rdfs:label "Menometrorrhagia" ; rdfs:subClassOf obo:HP_0000140 . obo:HP_0410000 obo:IAO_0000115 "An abnormality of the vomer." ; oboInOwl:hasDbXref "UMLS:C4020914" ; oboInOwl:hasExactSynonym "Abnormality of vomer", "Abnormality of vomer bone", "Defect of vomer" ; a owl:Class ; rdfs:label "Abnormal vomer morphology" ; rdfs:subClassOf obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410003 obo:IAO_0100001 "HP:0010289" ; a owl:Class ; rdfs:label "obsolete Cleft maxillary alveolus" ; owl:deprecated true . obo:HP_0410004 obo:IAO_0100001 "HP:0000175" ; a owl:Class ; rdfs:label "obsolete Cleft secondary palate" ; owl:deprecated true . obo:HP_0410005 oboInOwl:hasDbXref "SNOMEDCT_US:448915004", "UMLS:C0432090" ; oboInOwl:hasExactSynonym "Cleft bony palate", "Cleft of hard palate" ; a owl:Class ; rdfs:label "Cleft hard palate" ; rdfs:subClassOf obo:HP_0000175, obo:HP_0100737 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003216 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410006 obo:IAO_0000115 "Abnormality of the first branch of the internal carotid artery." ; oboInOwl:hasDbXref "UMLS:C4073185" ; oboInOwl:hasExactSynonym "Ophthalmic artery anomaly" ; a owl:Class ; rdfs:comment "The ophthalmic artery (OA) is the first branch of the internal carotid artery distal to the cavernous sinus. Branches of the OA supply all the structures in the orbit as well as some structures in the nose, face and meninges." ; rdfs:label "Abnormality of ophthalmic artery" ; rdfs:subClassOf obo:HP_3000062 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001619 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410007 obo:IAO_0100001 "HP:0002763" ; a owl:Class ; rdfs:label "obsolete Abnormality of cartilage morphology" ; owl:deprecated true . obo:HP_0410008 obo:IAO_0000115 "Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord." ; oboInOwl:hasDbXref "UMLS:C4073187" ; oboInOwl:hasExactSynonym "Abnormality of the peripheral nervous system" ; a owl:Class ; rdfs:label "Abnormality of the peripheral nervous system" ; rdfs:subClassOf obo:HP_0000707 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000010 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410009 obo:IAO_0000115 "Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements." ; oboInOwl:hasDbXref "UMLS:C4073188" ; a owl:Class ; rdfs:comment "The SoNS consists of afferent and efferent nerves. Afferent nerves are responsible for relaying sensation to the central nervous system; efferent nerves are responsible for stimulating muscle contraction, including all the non-sensory neurons connected with skeletal muscles and skin." ; rdfs:label "Abnormality of the somatic nervous system" ; rdfs:subClassOf obo:HP_0410008 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410010 obo:IAO_0000115 "Any abnormality of the somatic nerve plexus." ; oboInOwl:hasDbXref "UMLS:C4073189" ; a owl:Class ; rdfs:label "Abnormality of somatic nerve plexus" ; rdfs:subClassOf obo:HP_0410009 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001813 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410011 obo:IAO_0000115 "Any abnormality of the masticatory muscle." ; oboInOwl:hasDbXref "UMLS:C4073190" ; oboInOwl:hasExactSynonym "Abnormality of muscles of mastication" ; a owl:Class ; rdfs:label "Abnormality of masticatory muscle" ; rdfs:subClassOf obo:HP_0045037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410012 obo:IAO_0000115 "Any abnormality of the mouth floor." ; oboInOwl:hasDbXref "UMLS:C4073191" ; oboInOwl:hasExactSynonym "Abnormality of the floor of mouth", "Abnormality of the mouth floor" ; a owl:Class ; rdfs:label "Abnormal mouth floor morphology" ; rdfs:subClassOf obo:HP_0000163 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410013 obo:IAO_0000115 "Any abnormality of the submandibular region, the region between the mandible and the hyoid bone contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery." ; oboInOwl:hasDbXref "UMLS:C4073192" ; a owl:Class ; rdfs:label "Abnormality of the submandibular region" ; rdfs:subClassOf obo:HP_0000271 . obo:HP_0410014 obo:IAO_0000115 "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system." ; oboInOwl:hasDbXref "UMLS:C4073193" ; oboInOwl:hasExactSynonym "Abnormality of ganglion" ; a owl:Class ; rdfs:label "Abnormal ganglion morphology" ; rdfs:subClassOf obo:HP_0012639 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000045 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410015 obo:IAO_0000115 "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system." ; oboInOwl:hasDbXref "UMLS:C4073194" ; oboInOwl:hasExactSynonym "Abnormality of ganglion of peripheral nervous system" ; a owl:Class ; rdfs:label "Abnormal peripheral nervous system ganglion morphology" ; rdfs:subClassOf obo:HP_0410014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003338 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410016 obo:IAO_0000115 "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium." ; oboInOwl:hasDbXref "UMLS:C4073195" ; oboInOwl:hasExactSynonym "Abnormality of cranial ganglion" ; a owl:Class ; rdfs:label "Abnormal cranial ganglion morphology" ; rdfs:subClassOf obo:HP_0410014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410017 obo:IAO_0000115 "Inflammation or infection of the external auditory canal (EAC), the auricle, or both." ; oboInOwl:hasExactSynonym "Swimmer's ear" ; a owl:Class ; rdfs:label "Otitis externa" ; rdfs:subClassOf obo:HP_0000372 . obo:HP_0410018 obo:IAO_0000115 "Increased susceptibility to ear infections, as manifested by recurrent episodes of ear infections." ; oboInOwl:hasExactSynonym "Frequent ear infections", "Recurrent ear infections" ; a owl:Class ; rdfs:label "Recurrent ear infections" ; rdfs:subClassOf obo:HP_0002719 . obo:HP_0410019 obo:IAO_0000115 "Pain that is localized to the region of the upper abdomen immediately below the ribs." ; oboInOwl:hasExactSynonym "Epigastrium pain" ; a owl:Class ; rdfs:label "Epigastric pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0410020 obo:IAO_0000115 "Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylamine (TMA) in the urine, sweat, and breath of affected individuals." ; oboInOwl:hasExactSynonym "Fish odour", "Fishy body odor", "Fishy body odour", "Fishy odor", "Fishy odour" ; a owl:Class ; rdfs:label "Fish odor" ; rdfs:subClassOf obo:HP_0500001 . obo:HP_0410021 obo:IAO_0000115 "Pungent body odor." ; oboInOwl:hasExactSynonym "Musty odor", "Musty odour" ; a owl:Class ; rdfs:label "Musty odor" ; rdfs:subClassOf obo:HP_0500001 . obo:HP_0410022 obo:IAO_0000115 "A fish odor in the vaginal area, that is characteristic of bacterial vaginosis (BV), and is due to trimethylamine (TMA)." ; oboInOwl:hasExactSynonym "Vaginal fish odor", "Vaginal fish odour" ; a owl:Class ; rdfs:label "Vaginal fish odor" ; rdfs:subClassOf obo:HP_0410020 . obo:HP_0410023 obo:IAO_0000115 "An anomalous amount or location of cell junction proteins such as plakoglobin or Cx43." ; dcterms:creator ; a owl:Class ; rdfs:comment "Buccal mucosal cells are harvested from the oral mucosa in the region of the cheek, and can be used as a surrogate tissue to measure cell junction proteins because it is difficult to obtain cells from a tissue of interest such as the myocardium. Cell junction proteins, such as plakoglobin and the major cardiac gap junction protein Cx43 may have an abnormal distribution in diseases such as arrhythmogenic cardiomyopathy." ; rdfs:label "Abnormal distribution of cell junction proteins in buccal mucosal cells" ; rdfs:subClassOf obo:HP_0031476, obo:HP_3000019 . obo:HP_0410026 obo:IAO_0000115 "Any abnormality of the periodontium." ; dc:date "2017-06-20T21:40:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of the periodontium" ; a owl:Class ; rdfs:label "Abnormal periodontium morphology" ; rdfs:subClassOf obo:HP_0000164 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001758 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410027 obo:IAO_0000115 "A decrease in the amount of alveolar bone around the root of a tooth." ; dc:date "2017-06-20T21:41:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bone loss around teeth" ; a owl:Class ; rdfs:label "Alveolar bone loss around teeth" ; rdfs:subClassOf obo:HP_0410026 . obo:HP_0410028 obo:IAO_0000115 "Recurrent episodes of oral herpes, typically characterized by blisters or ulcers on the gums, lips and/or tongue caused by herpes virus." ; dc:date "2017-06-20T21:46:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Recurrent herpes labialis" ; a owl:Class ; rdfs:label "Recurrent oral herpes" ; rdfs:subClassOf obo:HP_0005353 . obo:HP_0410030 obo:IAO_0000115 "A gap in the lip or lips." ; dc:date "2017-06-20T22:17:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cleft lip", "Cleft of the lip" ; a owl:Class ; rdfs:label "Cleft lip" ; rdfs:subClassOf obo:HP_0000202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000609 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410031 obo:IAO_0000115 "Soft and hard-palate submucous clefts are characterized by bony defects in the midline of the soft and hard palate that are covered by the lining (ie mucous membrane) of the roof of the mouth." ; dc:date "2017-06-20T23:09:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Submucous cleft of soft and hard palate" ; rdfs:subClassOf obo:HP_0000175 . obo:HP_0410032 obo:IAO_0100001 "HP:0000193" ; a owl:Class ; rdfs:label "obsolete Cleft of uvula" ; owl:deprecated true . obo:HP_0410033 obo:IAO_0000115 "One sided alveolar cleft of the maxilla." ; dc:date "2017-06-20T23:37:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Consider adding additional annotations to specify the completeness of the cleft using 'Incomplete cleft maxillary alveolar ridge' (HP:5201007) or 'Complete cleft maxillary alveolar ridge' (HP:5201008)." ; rdfs:label "Unilateral alveolar cleft of maxilla" ; rdfs:subClassOf obo:HP_0010289 . obo:HP_0410034 obo:IAO_0000115 "Nonmidline alveolar cleft of the maxilla." ; dc:date "2017-06-20T23:37:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Consider adding additional annotations to specify the completeness of the cleft using 'Incomplete cleft maxillary alveolar ridge' (HP:5201007) or 'Complete cleft maxillary alveolar ridge' (HP:5201008)." ; rdfs:label "Bilateral alveolar cleft of maxilla" ; rdfs:subClassOf obo:HP_0010289 . obo:HP_0410035 obo:IAO_0000115 "Any abnormality in the activation of T cells, i.e. the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ; dc:date "2017-06-22T19:07:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal T lymphocyte activation", "Abnormal T-cell activation", "Abnormal T-lymphocyte activation" ; a owl:Class ; rdfs:label "Abnormal T cell activation" ; rdfs:subClassOf obo:HP_0011840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0042110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410042 obo:IAO_0000115 "Any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage." ; dc:date "2017-09-20T00:22:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:4447" ; a owl:Class ; rdfs:label "Abnormal liver morphology" ; rdfs:subClassOf obo:HP_0001392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410043 obo:IAO_0000115 "Any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)." ; dc:date "2017-09-20T00:25:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "Fyler:4339" ; a owl:Class ; rdfs:label "Abnormal neural tube morphology" ; rdfs:subClassOf obo:HP_0002011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001049 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410049 dc:date "2017-10-16T20:21:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of radial ray", "Deformity of radial ray", "Radial ray abnormality", "Radial ray anomaly", "Radial ray deformity" ; a owl:Class ; rdfs:comment "An abnormality of the radial ray; the thumb bones and 1st meta carpel." ; rdfs:label "Abnormal radial ray morphology" ; rdfs:subClassOf obo:HP_0002813 . obo:HP_0410050 obo:IAO_0000115 "A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues." ; dc:date "2018-01-27T00:26:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased level of 1,5-AG in serum", "Decreased level of 1,5-anhydro-D-glucitol in serum", "Decreased level of 1,5-anhydroglucitol in serum" ; a owl:Class ; rdfs:label "Decreased level of 1,5 anhydroglucitol in serum" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16070 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410051 obo:IAO_0000115 "The concentration of 3-hydroxy-3-methylglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2018-01-27T01:26:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased level of 3-hydroxy-3-methylglutaric acid in urine" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16831 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410052 obo:IAO_0000115 "An increase in the level of allantoin in the serum." ; dc:date "2018-01-27T01:42:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased level of allantoin in serum" ; rdfs:subClassOf obo:HP_0004364 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15676 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410053 obo:IAO_0000115 "An increase in the level of Gamma-aminobutyric acid (GABA) in the blood circulation." ; dc:date "2018-01-27T01:56:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032529" ; oboInOwl:hasExactSynonym "Increased circulating GABA concentration", "Increased level of GABA in serum", "Increased level of gamma-aminobutyric acid in serum" ; a owl:Class ; rdfs:comment "Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate." ; rdfs:label "Elevated circulating gamma-aminobutyric acid concentration" ; rdfs:subClassOf obo:HP_0034025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410054 obo:IAO_0000115 "A decrease in the level of GABA in the serum." ; dc:date "2018-01-27T01:56:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating gamma-aminobutyric acid concentration", "Decreased level of gamma-aminobutyric acid in serum" ; a owl:Class ; rdfs:label "Decreased circulating GABA concentration" ; rdfs:subClassOf obo:HP_0034025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410055 obo:IAO_0000115 "A decrease in the level of erythritol in the urine." ; dc:date "2018-01-27T02:15:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased level of erythritol in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17113 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410056 obo:IAO_0000115 "Concentration of erythritol in the cerebrospinal fluid below the lower limit of normal." ; dc:date "2018-01-27T02:15:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased level of erythritol in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF erythritol concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17113 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410057 obo:IAO_0000115 "An increase in the level of D-threitol in the plasma." ; dc:date "2018-01-27T02:34:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "D-threitol, a C4-polyol, is the main end product of D-xylose metabolism in humans." ; rdfs:label "Increased level of D-threitol in plasma" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_48300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410058 obo:IAO_0000115 "An increase in the level of D-threitol in the cerebrospinal fluid." ; dc:date "2018-01-27T02:34:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of D-threitol in cerebrospinal fluid" ; a owl:Class ; rdfs:comment "D-threitol, a C4-polyol, is the main end product of D-xylose metabolism in humans." ; rdfs:label "Increased level of D-threitol in CSF" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_48300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410059 obo:IAO_0000115 "An increase in the level of D-threitol in the urine." ; dc:date "2018-01-27T02:34:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "D-threitol, a C4-polyol, is the main end product of D-xylose metabolism in humans." ; rdfs:label "Increased level of D-threitol in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_48300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410060 obo:IAO_0000115 "A decrease in the level of D-mannose in the urine." ; dc:date "2018-01-29T22:01:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "D-Mannose is the 2-epimer of glucose." ; rdfs:label "Decreased level of D-mannose in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410061 obo:IAO_0000115 "An increase in the level of galactitol in the plasma." ; dc:date "2018-01-29T22:37:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased level of galactitol in plasma" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410062 obo:IAO_0000115 "An increase in the level of galactitol in the urine." ; dc:date "2018-01-29T22:38:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Galactitol is the reduction product of galactose." ; rdfs:label "Increased level of galactitol in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410063 obo:IAO_0000115 "An increase in the level of galactonate in the red blood cells." ; dc:date "2018-01-29T22:39:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of galactonate in RBCs", "Increased level of galactonate in erythrocytes" ; a owl:Class ; rdfs:label "Increased level of galactonate in red blood cells" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410064 obo:IAO_0000115 "An increase in the level of galactitol in the red blood cells." ; dc:date "2018-01-29T22:40:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of galactitol in erythrocytes" ; a owl:Class ; rdfs:label "Increased level of galactitol in red blood cells" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410065 obo:IAO_0000115 "An increase in the level of hippuric acid in the blood." ; dc:date "2018-01-29T22:41:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of N-benzoylglycine in blood" ; a owl:Class ; rdfs:label "Increased level of hippuric acid in blood" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18089 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410066 obo:IAO_0000115 "An increase in the level of hippuric acid in the urine." ; dc:date "2018-01-29T22:42:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of N-benzoylglycine in urine" ; a owl:Class ; rdfs:label "Increased level of hippuric acid in urine" ; rdfs:subClassOf obo:HP_0031980 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18089 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410067 obo:IAO_0000115 "An increase in the level of L-fucose in the urine." ; dc:date "2018-01-29T22:55:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Fucose is a hexose deoxy sugar with the chemical formula C6H12O5." ; rdfs:label "Increased level of L-fucose in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18287 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410068 obo:IAO_0100001 "HP:0500149" ; dc:date "2018-01-29T22:56:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Increased level of L-glutamic acid in blood" ; owl:deprecated true . obo:HP_0410069 obo:IAO_0000115 "An increase in the level of propylene glycol in the blood." ; dc:date "2018-01-29T22:57:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of propane-1,2-diol in blood" ; a owl:Class ; rdfs:label "Increased level of propylene glycol in blood" ; rdfs:subClassOf obo:HP_0032180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16997 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410070 obo:IAO_0000115 "An increase in the level of ribitol in the urine. Ribotol is a crystalline pentose alcohol (C5H12O5) and is a metabolic end product formed by the reduction of ribose." ; dc:date "2018-01-29T22:58:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased level of ribitol in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15963 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410071 obo:IAO_0000115 "An increase in the level of ribitol in the cerebral spinal fluid." ; dc:date "2018-01-29T22:59:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of ribitol in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased level of ribitol in CSF" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15963 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410072 obo:IAO_0000115 "An increase in the level of ribose in the urine." ; dc:date "2018-01-30T00:47:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Ribose is a pentose monosaccharide." ; rdfs:label "Increased level of ribose in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33942 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410073 obo:IAO_0000115 "An increase in the level of ribose in the cerebrospinal fluid." ; dc:date "2018-01-30T00:47:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of ribose in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased level of ribose in CSF" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33942 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410074 obo:IAO_0000115 "An increase in the level of xylitol in the urine." ; dc:date "2018-01-30T00:49:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased level of xylitol in urine" ; rdfs:subClassOf obo:HP_0031979 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410075 obo:IAO_0000115 "An increase in the level of xylitol in the cerebrospinal fluid." ; dc:date "2018-01-30T00:50:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of xylitol in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased level of xylitol in CSF" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17151 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410132 obo:IAO_0000115 "An increase in the level of L-pyroglutamic acid in the urine." ; dc:date "2018-02-22T18:07:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urine 5-oxoproline", "Increased level of 5-oxo-L-proline in urine" ; a owl:Class ; rdfs:label "Increased level of L-pyroglutamic acid in urine" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18183 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410133 obo:IAO_0000115 "Urticaria characterized by spontaneously recurring hives for 6 weeks or longer." ; dc:date "2018-03-02T19:33:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CIU", "CSU", "Chronic spontaneous urticaria" ; a owl:Class ; rdfs:label "Chronic idiopathic urticaria" ; rdfs:subClassOf obo:HP_0001025 . obo:HP_0410134 obo:IAO_0000115 "Urticaria caused by physical agents, such as heat, cold, light, friction." ; dc:date "2018-03-02T19:37:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Physical urticaria" ; rdfs:subClassOf obo:HP_0001025 . obo:HP_0410135 obo:IAO_0000115 "Urticaria may be caused by cold temperatures." ; dc:date "2018-03-02T19:45:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cold urticaria" ; rdfs:subClassOf obo:HP_0410134 . obo:HP_0410136 obo:IAO_0000115 "A form of physical urticaria, in which contact with water, regardless of its temperature and source, evokes pruritic follicular wheals on the skin." ; dc:date "2018-03-02T19:52:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aquagenic urticaria" ; rdfs:subClassOf obo:HP_0410134 . obo:HP_0410137 obo:IAO_0000115 "Urticaria in response to exposure to ultraviolet-A (UVA), ultraviolet-B (UVB), visible and rarely infrared light." ; dc:date "2018-03-02T20:07:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Solar urticaria" ; rdfs:subClassOf obo:HP_0000992, obo:HP_0410134 . obo:HP_0410138 obo:IAO_0000115 "Urticaria in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum." ; dc:date "2018-03-02T20:14:35Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vibratory urticaria" ; rdfs:subClassOf obo:HP_0410134 . obo:HP_0410139 obo:IAO_0000115 "Anaphylaxis after physical activity." ; dc:date "2018-03-02T20:22:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Exercise induced anaphylaxis" ; rdfs:subClassOf obo:HP_0100845 . obo:HP_0410144 obo:IAO_0000115 "An abnormality in the biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." ; dc:date "2018-03-12T20:12:17Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal biotinidase level" ; a owl:Class ; rdfs:label "Abnormal circulating biotinidase concentration" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0410145 obo:IAO_0000115 "Concentration of biotinidase in the blood circulation below the lower limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." ; dc:date "2018-03-12T20:14:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased biotinidase level" ; a owl:Class ; rdfs:label "Decreased circulating biotinidase concentration" ; rdfs:subClassOf obo:HP_0410144 . obo:HP_0410146 obo:IAO_0000115 "Concentration of biotinidase in the blood circulation above the upper limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." ; dc:date "2018-03-12T20:15:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased biotinidase level" ; a owl:Class ; rdfs:label "Elevated circulating biotinidase concentration" ; rdfs:subClassOf obo:HP_0410144 . obo:HP_0410147 obo:IAO_0000115 "Infiltration of eosinophils in the stomach mucosa, that is diagnosed by an upper endoscopy and microscopy that shows more than 20 eosinophils per high-power field in association with peripheral eosinophilia and the absence of secondary cause of eosinophilia." ; dc:date "2018-03-12T20:54:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic gastritis" ; a owl:Class ; rdfs:label "Eosinophilic infiltration in the stomach mucosa" ; rdfs:subClassOf obo:HP_0005263, obo:HP_0032064 . obo:HP_0410148 obo:IAO_0000115 "A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment." ; dc:date "2018-03-12T21:12:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Idiopathic anaphylaxis" ; rdfs:subClassOf obo:HP_0100845 . obo:HP_0410149 obo:IAO_0000115 "A form of anaphylaxis that is triggered by intake of drugs or medications." ; dc:date "2018-03-12T21:33:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Drug induced anaphylaxis" ; a owl:Class ; rdfs:label "Drug-induced anaphylaxis" ; rdfs:subClassOf obo:HP_0100845 . obo:HP_0410151 obo:IAO_0000115 "Infiltration of numerous eosinophils (usually greater than 15 per high power field) into the squamous epithelium of the esophagus, and layering of eosinophils on the surface layer of the esophagus." ; dc:date "2018-03-13T04:36:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic esophagitis", "Eosinophilic infiltration of the oesophagus" ; a owl:Class ; rdfs:label "Eosinophilic infiltration of the esophagus" ; rdfs:subClassOf obo:HP_0032064, obo:HP_0100633 . obo:HP_0410152 obo:IAO_0000115 "The formation of small localized collection of eosinophiles (an eosinophilic microabscess) in the esophagus. Usually clusters of greater than or equal to 4 eosinophils are seen, that appear as exudates or white spots or white plaques." ; dc:date "2018-03-13T04:43:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Eosinophilic micro-abscess formation in the esophagus", "Eosinophilic micro-abscess formation in the oesophagus", "Eosinophilic microabscess formation in the oesophagus" ; a owl:Class ; rdfs:label "Eosinophilic microabscess formation in the esophagus" ; rdfs:subClassOf obo:HP_0100633 . obo:HP_0410153 obo:IAO_0000115 "The concentration of methylsuccinic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dc:date "2018-03-27T21:49:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of pyrotartaric acid in urine" ; a owl:Class ; rdfs:label "Increased level of methylsuccinic acid in urine" ; rdfs:subClassOf obo:HP_0003215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_89843 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410154 obo:IAO_0000115 "An increase in the level of myristic acid in the serum." ; dc:date "2018-03-27T21:58:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of tetradecanoic acid in serum" ; a owl:Class ; rdfs:label "Increased level of myristic acid in serum" ; rdfs:subClassOf obo:HP_0010996 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28875 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001977 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410156 obo:IAO_0000115 "An increase in the level of N-acetylneuraminic acid in the urine." ; dc:date "2018-03-28T00:27:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of NANA in urine", "Increased level of Neu5Ac in urine" ; a owl:Class ; rdfs:label "Increased level of N-acetylneuraminic acid in urine" ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17012 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410157 obo:IAO_0000115 "An increase in the level of N-acetylneuraminic acid in cultured fibroblasts." ; dc:date "2018-03-28T19:40:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of NANA in fibroblasts", "Increased level of Neu5Ac in fibroblasts", "Increased level of sialic acid in fibroblasts" ; a owl:Class ; rdfs:label "Increased level of N-acetylneuraminic acid in fibroblasts" ; rdfs:subClassOf obo:HP_0032243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17012 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000057 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410158 obo:IAO_0100001 "HP:0003239" ; dc:date "2018-03-28T19:43:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of O-phosphoethanolamine in urine" ; a owl:Class ; rdfs:label "obsolete Increased urine O-phosphoethanolamine level" ; owl:deprecated true . obo:HP_0410166 obo:IAO_0000115 "A defect in the of the process of interstrand cross-link repair: removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." ; dc:date "2018-05-01T17:32:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Defective interstrand cross-link repair" ; rdfs:subClassOf obo:HP_0003254 . obo:HP_0410167 obo:IAO_0000115 "Any abnormality of the chest muscles." ; dc:date "2018-05-01T17:37:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Muscle issues in the chest" ; oboInOwl:hasExactSynonym "Abnormality of the chest musculature" ; a owl:Class ; rdfs:label "Abnormal morphology of the chest musculature" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002426 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410168 obo:IAO_0000115 "Any abnormality of the back muscles." ; dc:date "2018-05-01T17:38:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Muscle issues in the back" ; a owl:Class ; rdfs:label "Abnormality of the back musculature" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002324 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410169 obo:IAO_0000115 "Any abnormality of the shoulder muscles." ; dc:date "2018-05-01T17:39:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of the shoulder musculature", "Muscle issues in the shoulder" ; a owl:Class ; rdfs:label "Abnormal morphology of the shoulder musculature" ; rdfs:subClassOf obo:HP_0011805 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410170 obo:IAO_0000115 "Partial or complete wasting (loss) of hippocampus tissue that was once present." ; dc:date "2018-05-07T18:29:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atrophy of the hippocampus", "Degeneration of the hippocampus" ; a owl:Class ; rdfs:comment "The hippocampus is part of the temporal cortex (albeit allocortex rather than neocortex)." ; rdfs:label "Hippocampal atrophy" ; rdfs:subClassOf obo:HP_0007112, obo:HP_0025100 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410171 obo:IAO_0000115 "Increased concentration of cotinine in urine." ; dc:date "2018-05-18T17:47:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cotinine is the main metabolite of nicotine and accumulates in the body as a result of tobacco exposure. In humans, cotinine is excreted in the urine, mainly as trans-3[prime]-hydroxycotinine and glucuronide. This is used as a measure for exposure to tobacco smoke." ; rdfs:label "Increased cotinine level" ; rdfs:subClassOf obo:HP_0031840 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_68641 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410172 obo:IAO_0000115 "The presence of a xenobiotic in blood." ; dc:date "2018-05-18T18:31:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Blood xenobiotic" ; rdfs:subClassOf obo:HP_0031838 . obo:HP_0410173 obo:IAO_0000115 "An increased concentration of tropnin I in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction." ; dc:date "2018-05-18T20:20:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased troponin I level in blood" ; a owl:Class ; rdfs:label "Increased circulating troponin I concentration" ; rdfs:subClassOf obo:HP_0500020 . obo:HP_0410174 obo:IAO_0000115 "An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction." ; dc:date "2018-05-18T20:21:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased troponin T level in blood" ; a owl:Class ; rdfs:label "Increased circulating troponin T concentration" ; rdfs:subClassOf obo:HP_0500020 . obo:HP_0410175 obo:IAO_0000115 "An increase in the level of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the blood." ; dc:date "2018-05-21T17:36:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating ketone body concentration", "Increased level of ketone bodies in blood", "Ketonemia" ; a owl:Class ; rdfs:label "Hyperketonemia" ; rdfs:subClassOf obo:HP_0001946 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410176 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase." ; dc:date "2018-05-21T17:49:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level", "Abnormal glucose-6-phosphate dehydrogenase level" ; a owl:Class ; rdfs:label "Abnormal circulating glucose-6-phosphate dehydrogenase concentration" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000007749 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410177 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase in the blood." ; dc:date "2018-05-21T17:54:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level in blood" ; a owl:Class ; rdfs:label "Abnormal glucose-6-phosphate dehydrogenase level in blood" ; rdfs:subClassOf obo:HP_0410176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410178 obo:IAO_0000115 "An increase in the level of glucose-6-phosphate dehydrogenase in the blood." ; dc:date "2018-05-21T17:55:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased G6PD level in blood" ; a owl:Class ; rdfs:label "Increased glucose-6-phosphate dehydrogenase level in blood" ; rdfs:subClassOf obo:HP_0410177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410179 obo:IAO_0000115 "A decrease in the level of glucose-6-phosphate dehydrogenase in the blood." ; dc:date "2018-05-21T17:55:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased G6PD level in blood" ; a owl:Class ; rdfs:label "Decreased glucose-6-phosphate dehydrogenase level in blood" ; rdfs:subClassOf obo:HP_0410177 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410180 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." ; dc:date "2018-05-21T17:57:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level in dried blood spot", "Abnormal glucose-6-phosphate dehydrogenase level in DBS" ; a owl:Class ; rdfs:label "Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot" ; rdfs:subClassOf obo:HP_0410176 . obo:HP_0410181 obo:IAO_0000115 "An increase in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." ; dc:date "2018-05-21T17:58:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased G6PD level in dried blood spot", "Increased glucose-6-phosphate dehydrogenase level in DBS" ; a owl:Class ; rdfs:label "Increased glucose-6-phosphate dehydrogenase level in dried blood spot" ; rdfs:subClassOf obo:HP_0410180 . obo:HP_0410182 obo:IAO_0000115 "A decrease in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." ; dc:date "2018-05-21T17:58:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased G6PD level in dried blood spot", "Decreased glucose-6-phosphate dehydrogenase level in DBS" ; a owl:Class ; rdfs:label "Decreased glucose-6-phosphate dehydrogenase level in dried blood spot" ; rdfs:subClassOf obo:HP_0410180 . obo:HP_0410183 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase in leukocytes." ; dc:date "2018-05-21T18:00:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level in leukocytes" ; a owl:Class ; rdfs:label "Abnormal glucose-6-phosphate dehydrogenase level in leukocytes" ; rdfs:subClassOf obo:HP_0410176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410184 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase in red blood cells." ; dc:date "2018-05-21T18:01:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level in RBCs", "Abnormal G6PD level in red blood cells" ; a owl:Class ; rdfs:label "Abnormal glucose-6-phosphate dehydrogenase level in red blood cells" ; rdfs:subClassOf obo:HP_0410176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410185 obo:IAO_0000115 "An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue." ; dc:date "2018-05-21T18:01:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal G6PD level in tissue" ; a owl:Class ; rdfs:label "Abnormal glucose-6-phosphate dehydrogenase level in tissue" ; rdfs:subClassOf obo:HP_0410176 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410186 obo:IAO_0000115 "An increase in the level of glucose-6-phosphate dehydrogenase in tissue." ; dc:date "2018-05-21T18:03:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased G6PD level in tissue" ; a owl:Class ; rdfs:label "Increased glucose-6-phosphate dehydrogenase level in tissue" ; rdfs:subClassOf obo:HP_0410185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410187 obo:IAO_0000115 "A decrease in the level of glucose-6-phosphate dehydrogenase in tissue." ; dc:date "2018-05-21T18:03:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased G6PD level in tissue" ; a owl:Class ; rdfs:label "Decreased glucose-6-phosphate dehydrogenase level in tissue" ; rdfs:subClassOf obo:HP_0410185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410188 obo:IAO_0000115 "A decrease in the level of glucose-6-phosphate dehydrogenase in red blood cells." ; dc:date "2018-05-21T18:03:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased G6PD level in RBCs", "Decreased G6PD level in red blood cells" ; a owl:Class ; rdfs:label "Decreased glucose-6-phosphate dehydrogenase level in red blood cells" ; rdfs:subClassOf obo:HP_0410184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410189 obo:IAO_0000115 "An increase in the level of glucose-6-phosphate dehydrogenase in red blood cells." ; dc:date "2018-05-21T18:03:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased G6PD level in RBCs", "Increased G6PD level in red blood cells" ; a owl:Class ; rdfs:label "Increased glucose-6-phosphate dehydrogenase level in red blood cells" ; rdfs:subClassOf obo:HP_0410184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410190 obo:IAO_0000115 "A decrease in the level of glucose-6-phosphate dehydrogenase in leukocytes." ; dc:date "2018-05-21T18:04:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased G6PD level in leukocytes" ; a owl:Class ; rdfs:label "Decreased glucose-6-phosphate dehydrogenase level in leukocytes" ; rdfs:subClassOf obo:HP_0410183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410191 obo:IAO_0000115 "An increase in the level of glucose-6-phosphate dehydrogenase in leukocytes." ; dc:date "2018-05-21T18:04:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased G6PD level in leukocytes" ; a owl:Class ; rdfs:label "Increased glucose-6-phosphate dehydrogenase level in leukocytes" ; rdfs:subClassOf obo:HP_0410183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007749 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000738 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410192 obo:IAO_0000115 "An abnormality in uridine diphosphate glucose-4-epimerase level, an enzyme that catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:22:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal UDP-glucose 4-epimerase level" ; a owl:Class ; rdfs:label "Abnormal uridine diphosphate glucose-4-epimerase level" ; rdfs:subClassOf obo:HP_0012379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:PR_000007812 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410193 obo:IAO_0000115 "An abnormality in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:23:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal UDP-glucose 4-epimerase activity level in plasma" ; a owl:Class ; rdfs:label "Abnormal uridine diphosphate glucose-4-epimerase level in plasma" ; rdfs:subClassOf obo:HP_0410192 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410194 obo:IAO_0000115 "An increase in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:23:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased UDP-glucose 4-epimerase level in plasma" ; a owl:Class ; rdfs:label "Increased uridine diphosphate glucose-4-epimerase level in plasma" ; rdfs:subClassOf obo:HP_0410193 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410195 obo:IAO_0000115 "A decrease in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:23:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased UDP-glucose 4-epimerase level in plasma" ; a owl:Class ; rdfs:label "Decreased uridine diphosphate glucose-4-epimerase level in plasma" ; rdfs:subClassOf obo:HP_0410193 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410196 obo:IAO_0000115 "An abnormality in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:24:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal UDP-glucose 4-epimerase level in RBCs", "Abnormal UDP-glucose 4-epimerase level in red blood cells" ; a owl:Class ; rdfs:label "Abnormal uridine diphosphate glucose-4-epimerase level in red blood cells" ; rdfs:subClassOf obo:HP_0410192 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410197 obo:IAO_0000115 "An increase in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:24:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased UDP-glucose 4-epimerase level in RBCs", "Increased UDP-glucose 4-epimerase level in red blood cells" ; a owl:Class ; rdfs:label "Increased uridine diphosphate glucose-4-epimerase level in red blood cells" ; rdfs:subClassOf obo:HP_0410196 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410198 obo:IAO_0000115 "A decrease in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose." ; dc:date "2018-05-21T18:24:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased UDP-glucose 4-epimerase level in RBCs", "Decreased UDP-glucose 4-epimerase level in red blood cells" ; a owl:Class ; rdfs:label "Decreased uridine diphosphate glucose-4-epimerase level in red blood cells" ; rdfs:subClassOf obo:HP_0410196 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007812 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000232 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410199 obo:IAO_0000115 "Increased concentration of urate in the cerebrospinal fluid." ; dc:date "2018-07-20T22:56:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated CSF urate concentration", "Increased cerebrospinal fluid urate" ; a owl:Class ; rdfs:label "Increased CSF urate concentration" ; rdfs:subClassOf obo:HP_0500117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_46819 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410200 obo:IAO_0000115 "Detection of barbiturate metabolites such as phenobarbital in meconium." ; dc:date "2018-07-20T23:02:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive meconium barbiturate test" ; rdfs:subClassOf obo:HP_0500098 . obo:HP_0410201 obo:IAO_0000115 "Detection of barbiturate metabolites such as phenobarbital in the hair." ; dc:date "2018-07-20T23:03:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive hair barbiturate test" ; rdfs:subClassOf obo:HP_0500099 . obo:HP_0410202 obo:IAO_0000115 "Detection of barbiturate metabolites such as phenobarbital in the stool." ; dc:date "2018-07-20T23:04:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive stool barbiturate test" ; rdfs:subClassOf obo:HP_0500097 . obo:HP_0410203 obo:IAO_0000115 "Detection of barbiturate metabolites such as phenobarbital in the gastric fluid." ; dc:date "2018-07-20T23:04:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive gastric fluid barbiturate test" ; rdfs:subClassOf obo:HP_0500101 . obo:HP_0410204 obo:IAO_0000115 "An increase in the length of time required for food to pass through the intestines." ; dc:date "2018-08-15T02:19:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased intestinal transit time" ; rdfs:subClassOf obo:HP_0030896 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000498 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0120054 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410205 obo:IAO_0000115 "Any deviation from the normal concentration of nicotinurate in the blood." ; dc:date "2018-09-11T23:40:08Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating N-nicotinoylglycine level", "Abnormal circulating nicotinurate level" ; a owl:Class ; rdfs:comment "Nicotinuric acid is an acyl glycine, which are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Nicotinuric acid is the major detoxification product of nicotinic acid. It may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid." ; rdfs:label "Abnormal circulating nicotinurate concentration" ; rdfs:subClassOf obo:HP_0004364 . obo:HP_0410206 obo:IAO_0000115 "An increased amount of nicotinurate in the blood." ; dc:date "2018-09-11T23:40:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating N-nicotinoylglycine level" ; a owl:Class ; rdfs:label "Increased circulating nicotinurate level" ; rdfs:subClassOf obo:HP_0410205 . obo:HP_0410207 obo:IAO_0000115 "Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in plasma or serum." ; dc:date "2018-09-11T23:47:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Methadone is an opioid drug that is used to treat severe pain or in the treatment of individiuals with opioid dependency." ; rdfs:label "Positive methadone plasma/serum test" ; rdfs:subClassOf obo:HP_0500100 . obo:HP_0410208 obo:IAO_0000115 "Detection of cotinine, an alkaloid found in tobacco and the predominant metabolite of nicotine, in plasma or serum." ; dc:date "2018-09-11T23:57:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cotinine is used as a biomarker for exposure to tobacco smoke." ; rdfs:label "Positive plasma/serum cotinine test" ; rdfs:subClassOf obo:HP_0500100 . obo:HP_0410209 obo:IAO_0000115 "A reduced concentration of folic acid, which is also known as vitamin B9 in the cerebrospinal fluid." ; dc:date "2018-09-12T00:12:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Folate deficiency in cerebrospinal fluid" ; a owl:Class ; rdfs:comment "Cerebral folate deficiency is usually measured as low levels of folate in the CSF, in the presence of normal folate metabolism outside the nervous system." ; rdfs:label "Folate deficiency in CSF" ; rdfs:subClassOf obo:HP_0012335 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410210 obo:IAO_0000115 "An abnormality in any umbilical cord measurement performed after birth, such as the blood gas level." ; dc:date "2018-09-12T00:35:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cord blood measurement" ; rdfs:subClassOf obo:HP_0010881 . obo:HP_0410211 dc:date "2018-09-12T00:44:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal blood gas level in cord blood" ; rdfs:subClassOf obo:HP_0410210 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_138675 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410212 obo:IAO_0000115 "An abnormally high level of blood oxygen in the cord blood." ; dc:date "2018-09-12T00:44:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High cord blood oxygen level" ; a owl:Class ; rdfs:label "Hyperoxemia in cord blood" ; rdfs:subClassOf obo:HP_0500259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410213 obo:IAO_0000115 "An abnormally low level of blood oxygen in the cord blood." ; dc:date "2018-09-12T00:44:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low cord blood oxygen level" ; a owl:Class ; rdfs:label "Hypoxemia in cord blood" ; rdfs:subClassOf obo:HP_0500259 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410214 obo:IAO_0000115 "Abnormally elevated blood carbon dioxide (CO2) level in the cord blood." ; dc:date "2018-09-12T00:44:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High cord blood carbon dioxide level" ; a owl:Class ; rdfs:label "Hypercapnia in cord blood" ; rdfs:subClassOf obo:HP_0500258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410215 obo:IAO_0000115 "Abnormally decreased blood carbon dioxide (CO2) level in the cord blood." ; dc:date "2018-09-12T00:44:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low cord blood carbon dioxide level" ; a owl:Class ; rdfs:label "Hypocapnia in cord blood" ; rdfs:subClassOf obo:HP_0500258 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410216 obo:IAO_0000115 "An abnormal concentration of 5-methyltetrahydrofolate in the blood." ; dc:date "2018-09-12T00:50:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serum methylfolate Level" ; a owl:Class ; rdfs:label "Abnormal blood 5-methyltetrahydrofolate level" ; rdfs:subClassOf obo:HP_0012335 . obo:HP_0410217 obo:IAO_0000115 "A decreased concentration of 5-methyltetrahydrofolate in the blood." ; dc:date "2018-09-12T00:51:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced serum methylfolate Level" ; a owl:Class ; rdfs:label "Reduced blood 5-methyltetrahydrofolate level" ; rdfs:subClassOf obo:HP_0410216 . obo:HP_0410218 obo:IAO_0000115 "Abnormally small dimension of the maxilla (upper jaw) relative to the mandible (lower jaw)." ; dc:date "2018-09-25T00:46:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Disorder of maxillary and mandibular dental arch relationship" ; a owl:Class ; rdfs:label "Hypoplasia of maxilla relative to mandible" ; rdfs:subClassOf obo:HP_0000327 . obo:HP_0410219 obo:IAO_0000115 "Abnormally small dimension of the mandible (lower jaw) relative to the maxilla (upper jaw)." ; dc:date "2018-09-25T00:54:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Disorder of mandibular and maxillary dental arch relationship" ; a owl:Class ; rdfs:label "Hypoplasia of mandible relative to maxilla" ; rdfs:subClassOf obo:HP_0000347 . obo:HP_0410220 obo:IAO_0000115 "Increased level of IgE antibody against dairy proteins, including casein, alpha-lactalbumin, beta-lactoglobulin or bovine serum albumin contained in cow, sheep or goat milk and milk products." ; dc:date "2018-10-03T16:47:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasRelatedSynonym "Increased anti-dairy IgE antibody level" ; a owl:Class ; rdfs:label "Increased anti-dairy protein IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410221 obo:IAO_0000115 "Increased level of IgE antibody against animal proteins, such as albumins that are present in animal hair, dander, shed skin, saliva and urine." ; dc:date "2018-10-03T16:51:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-animal protein IgE antibody" ; a owl:Class ; rdfs:comment "For animal dander annotations, there is a more specific subclass of this term." ; rdfs:label "Increased anti-animal protein IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410222 obo:IAO_0000115 "Increased level of IgE antibody against seafood, including fish, shrimp, lobster, crab, squid and abalone." ; dc:date "2018-10-03T16:51:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-seafood IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-seafood IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410223 obo:IAO_0000115 "Increased level of IgE antibody against dust mites, such as house dust mites." ; dc:date "2018-10-03T16:52:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-dust mite IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-dust mite IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410224 obo:IAO_0000115 "Increased level of IgE antibody against bacteria." ; dc:date "2018-10-03T16:52:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-bacteria IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-bacteria IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410225 obo:IAO_0000115 "Increased level of IgE antibody against a drug or class of drugs, such as antibiotics." ; dc:date "2018-10-03T18:09:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-drug IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-drug IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410226 obo:IAO_0000115 "Increased level of IgE antibody against feathers, which could be indicative of an allergy against feathers themselves, or mite allergens present in feathers." ; dc:date "2018-10-03T18:40:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-feather IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410227 obo:IAO_0000115 "Increased level of IgE antibody against proteins found in foods, such as milk, egg, soy, wheat, peanut, treenut, fish, and shellfish." ; dc:date "2018-10-03T21:27:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-food allergen IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-food allergen IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410228 obo:IAO_0000115 "Increased level of IgE antibody against a plant based food allergen, including vegetables and fruits." ; dc:date "2018-10-03T21:28:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-plant based food allergen IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-plant based food allergen IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410229 obo:IAO_0000115 "Increased level of IgE antibody against gluten, a protein found in wheat, barley, and rye." ; dc:date "2018-10-03T21:29:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-gluten IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-gluten IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410230 obo:IAO_0000115 "Increased level of IgE antibody against nut food products such as peanuts or tree nuts, such as hazelnuts, walnuts, cashews, and almonds." ; dc:date "2018-10-03T21:34:16Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-nut food product IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410231 obo:IAO_0000115 "Increased level of IgE antibody against eggs, including egg whites, egg yolks, and egg proteins such as ovoalbumin and ovomucoid." ; dc:date "2018-10-03T21:39:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-egg IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410232 obo:IAO_0000115 "Increased level of IgE antibody against fungus, such as molds like zygomycota, ascomycota and deuteromycota." ; dc:date "2018-10-03T21:57:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased anti-fungal IgE antibody level", "Increased anti-fungus IgE antibody level" ; a owl:Class ; rdfs:label "Increased anti-fungi IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410233 obo:IAO_0000115 "Increased level of IgE antibody against meat, such as mammalian meat, including beef or pork, or poultry, like duck or chicken." ; dc:date "2018-10-03T22:02:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-meat allergen IgE antibody level" ; rdfs:subClassOf obo:HP_0410227 . obo:HP_0410234 obo:IAO_0000115 "Increased level of IgE antibody against parasites, such as helminths (parasitic worms, such as Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenalis, Necator americanus, Strongyloides stercoralis) or parasites such as Toxoplasma gondii." ; dc:date "2018-10-03T22:42:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-parasite IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410235 obo:IAO_0000115 "Increased level of IgE antibody against antigens from insects such as moths, mosquitos, or cockroaches." ; dc:date "2018-10-03T22:38:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-insect IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410236 obo:IAO_0000115 "Increased level of IgE antibody against venom from insects such as bees, wasps, hornets, yellowjackets." ; dc:date "2018-10-03T22:40:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-venom IgE antibody level" ; rdfs:subClassOf obo:HP_0410235 . obo:HP_0410238 obo:IAO_0000115 "Increased level of IgE antibody against antigens from plants and products derived from plants, such as wood or pollen." ; dc:date "2018-10-03T23:09:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Increased anti-plant product IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410239 obo:IAO_0000115 "Detection of norcotinine, a metabolite of nicotine, in urine." ; dc:date "2018-10-09T23:11:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive urine norcotinine test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0410240 obo:IAO_0000115 "An abnormal deviation from normal levels of IgA immunoglobulin in blood." ; dc:date "2018-10-12T20:32:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal IgA level in blood" ; a owl:Class ; rdfs:label "Abnormal circulating IgA level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071746 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410241 obo:IAO_0000115 "An abnormal deviation from normal levels of IgE immunoglobulin in blood." ; dc:date "2018-10-12T20:32:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal IgE level in blood" ; a owl:Class ; rdfs:label "Abnormal circulating IgE level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071743 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410242 obo:IAO_0000115 "An abnormal deviation from normal levels of IgG immunoglobulin in blood." ; dc:date "2018-10-12T20:32:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal IgG level in blood" ; a owl:Class ; rdfs:label "Abnormal circulating IgG level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071736 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410243 obo:IAO_0000115 "An abnormal deviation from normal levels of IgM immunoglobulin in blood." ; dc:date "2018-10-12T20:32:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal IgM level in blood" ; a owl:Class ; rdfs:label "Abnormal circulating IgM level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410244 obo:IAO_0000115 "An abnormal deviation from normal levels of IgD immunoglobulin in blood." ; dc:date "2018-10-12T20:42:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal IgD level in blood" ; a owl:Class ; rdfs:label "Abnormal circulating IgD level" ; rdfs:subClassOf obo:HP_0010701 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071739 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410245 obo:IAO_0000115 "An abnormally decreased level of immunoglobulin D (IgD) in blood." ; dc:date "2018-10-12T20:43:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased IgD", "Decreased IgD in blood", "IgD deficiency" ; a owl:Class ; rdfs:label "Decreased circulating IgD" ; rdfs:subClassOf obo:HP_0004313, obo:HP_0410244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071739 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410246 obo:IAO_0000115 "An abnormally increased level of immunoglobulin D in blood." ; dc:date "2018-10-12T20:43:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated IgD", "Elevated serum IgD", "IgD hypergammaglobulinemia", "Increased IgD level", "Increased levels of IgD", "Increased serum IgD" ; a owl:Class ; rdfs:label "Increased circulating IgD level" ; rdfs:subClassOf obo:HP_0010702, obo:HP_0410244 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0071739 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410247 obo:IAO_0000115 "Increased level of IgE antibody against animal dander, tiny scales shed from animal skin or hair, such as from pet dogs or cats." ; dc:date "2018-10-12T20:49:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased level of anti-dander IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-animal dander IgE antibody level" ; rdfs:subClassOf obo:HP_0410221 . obo:HP_0410248 obo:IAO_0000115 "Increased level of IgE antibody against house dust mites, a common allergen." ; dc:date "2018-10-12T20:56:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased anti-house dust IgE antibody level", "Increased level of anti-house dust IgE antibody" ; a owl:Class ; rdfs:label "Increased anti-house dust mite IgE antibody level" ; rdfs:subClassOf obo:HP_0410223 . obo:HP_0410249 obo:IAO_0000115 "Increased level of IgE antibody against galactose-alpha-1, 3 galactose (alpha-gal), a carbohydrate found in mammalian meat." ; dc:date "2018-10-15T17:54:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased anti-galactose-alpha-1, 3 galactose IgE antibody level" ; a owl:Class ; rdfs:label "Increased anti-alpha-gal IgE antibody level" ; rdfs:subClassOf obo:HP_0032336 . obo:HP_0410251 obo:IAO_0000115 "An abnormality in the cleavage of L-selectin during the process of guiding neutrophils to the site of infection. Proteolytic cleavage of L-selectin results in rapid shedding from the cell surface, which has a role in neutrophil rolling and accumulation at the site of infection." ; dc:date "2018-10-19T17:56:39Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal L-selectin shedding" ; rdfs:subClassOf obo:HP_0011990 . obo:HP_0410252 obo:IAO_0000115 "Neutropenia with an absolute neutrophil count (ANC) less than 1,500,000,000/L lasting for more than 3 months." ; dc:date "2018-10-19T18:25:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Chronic neutropenia" ; rdfs:subClassOf obo:HP_0001875 . obo:HP_0410253 obo:IAO_0000115 "Chornic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow." ; dc:date "2018-10-19T18:41:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Myeloid maturation arrest in bone marrow" ; a owl:Class ; rdfs:label "Myeloid maturation arrest" ; rdfs:subClassOf obo:HP_0033606 . obo:HP_0410254 obo:IAO_0000115 "Cyclic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow." ; dc:date "2018-10-19T18:52:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Cyclic neutropenia in myeloid maturation arrest in bone marrow" ; rdfs:subClassOf obo:HP_0040289 . obo:HP_0410255 obo:IAO_0000115 "A transient reduction in the number of neutrophils in the peripheral blood. Transient neutropenia is most commonly associated with viral infections, but other causes include drugs and autoimmunity." ; dc:date "2018-10-19T18:57:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transient neutropenia" ; rdfs:subClassOf obo:HP_0001875 . obo:HP_0410256 obo:IAO_0000115 "Transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan." ; dc:date "2018-10-19T19:13:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Infection associated neutropenia" ; rdfs:subClassOf obo:HP_0410255 . obo:HP_0410257 obo:IAO_0000115 "An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus." ; dc:date "2018-10-19T19:22:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neutrophilia in presence of infection" ; rdfs:subClassOf obo:HP_0011897 . obo:HP_0410258 obo:IAO_0000115 "An increased number of neutrophils circulating in the blood in the absence of an infection. Factors contributing to neutrophilia could include inflammation or congenital disorders." ; dc:date "2018-10-19T19:23:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Neutrophilia in absence of infection" ; rdfs:subClassOf obo:HP_0011897 . obo:HP_0410259 obo:IAO_0000115 "Fusion of the liver with the lung." ; dc:date "2018-10-19T21:35:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Hepatic pulmonary fusion" ; a owl:Class ; rdfs:label "Hepatopulmonary fusion" ; rdfs:subClassOf obo:HP_0410042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000642 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410260 obo:IAO_0000115 "The presence of an asymmetrical gluteal crease, the horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg." ; dc:date "2018-10-19T21:42:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Asymmetrical buttock crease", "Asymmetrical gluteal sulcus", "Asymmetrical horizontal gluteal crease" ; a owl:Class ; rdfs:label "Asymmetrical gluteal crease" ; rdfs:subClassOf obo:HP_0001437 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000616 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0036014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410261 obo:IAO_0000115 "A widely spaced gap between the fourth toe and the fifth (pinky) toe." ; dc:date "2018-10-19T22:00:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Wide space between the 4th and 5th toe" ; a owl:Class ; rdfs:label "Wide space between 4th and 5th toe" ; rdfs:subClassOf obo:HP_0010321 . obo:HP_0410262 obo:IAO_0000115 "A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves." ; dc:date "2018-10-19T22:03:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal lower cranial nerve function" ; a owl:Class ; rdfs:label "Lower cranial nerve dysfunction" ; rdfs:subClassOf obo:HP_0031910 . obo:HP_0410263 obo:IAO_0000115 "An anomaly of metabolism or structure of the brain identified by imaging." ; dc:date "2018-10-19T22:17:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal brain imaging" ; a owl:Class ; rdfs:label "Brain imaging abnormality" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0410264 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, located in the airway, typically below the vocal chords, that can cause severe obstruction of the airway." ; dc:date "2018-10-30T01:47:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Airway hemangioma" ; a owl:Class ; rdfs:label "Subglottic hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410265 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, located in the upper part of the larynx (voice box) including the epiglottis; the area above the vocal cords." ; dc:date "2018-10-30T01:49:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Supraglottic hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410266 obo:IAO_0000115 "A hemangioma arising from within visceral structures, the internal organs of the body." ; dc:date "2018-10-30T01:56:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Visceral hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410267 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, located in the intestines, which includes the bowel." ; dc:date "2018-10-30T01:56:39Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bowel hemangioma", "Intestinal hemangiomas" ; a owl:Class ; rdfs:label "Intestinal hemangioma" ; rdfs:subClassOf obo:HP_0410266 . obo:HP_0410268 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the spleen." ; dc:date "2018-10-30T01:57:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Splenic hemangioma" ; a owl:Class ; rdfs:label "Spleen hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410269 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the upper lip." ; dc:date "2018-10-30T02:07:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Labial hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410270 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the esophagus." ; dc:date "2018-10-30T02:10:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Esophageal hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410271 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the glottic or supraglottic regions." ; dc:date "2018-10-30T02:15:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Throat hemangioma" ; a owl:Class ; rdfs:label "Laryngeal hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410272 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the vulva." ; dc:date "2018-10-30T02:17:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Vulvar hemangioma" ; rdfs:subClassOf obo:HP_0001028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001028 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005056 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410273 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the retropharyngeal space, the portion of the peripharyngeal space that is located posterior to the pharynx." ; dc:date "2018-10-30T02:17:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasDbXref "NCIT:C3085" ; a owl:Class ; rdfs:label "Retropharyngeal hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410274 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the paraspinal muscular region, the muscles next to the spine." ; dc:date "2018-10-30T02:21:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paraspinal hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410275 obo:IAO_0000115 "A spinal cord hemangioma located in the lumbosacral spine region." ; dc:date "2018-10-30T02:21:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lumbar/sacral hemangioma" ; a owl:Class ; rdfs:label "Lumbosacral hemangioma" ; rdfs:subClassOf obo:HP_0001028 . obo:HP_0410276 obo:IAO_0000115 "An abnormality of the sternum that presents at birth as a ventral sternal non-union defect, due to an abnormality of the fusion of the layers of the skin. It presents as a scar-like line that extends upward from the umbilicus (belly button)." ; dc:date "2018-10-30T18:16:55Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Midline supraumbilical raphe" ; a owl:Class ; rdfs:label "Supraumbilical raphe" ; rdfs:subClassOf obo:HP_0000766 . obo:HP_0410277 obo:IAO_0000115 "A sternal pit is a small indentation or dimple in the skin overlying the sternum of the chest. In some cases, the skin defect can be linear, extending several inches over the sternum." ; dc:date "2018-10-30T18:23:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Sternal pit" ; rdfs:subClassOf obo:HP_0000766 . obo:HP_0410278 obo:IAO_0000115 "A fluid-filled sacs that develop on or near the pituitary gland." ; dc:date "2018-10-30T19:49:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cyst of the pituitary gland" ; a owl:Class ; rdfs:label "Pituitary gland cyst" ; rdfs:subClassOf obo:HP_0010576 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001673 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410279 obo:IAO_0000115 "Partial or complete wasting (loss) of the pituitary gland." ; dc:date "2018-10-30T19:54:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Atrophic pituitary", "Pituitary gland atrophy" ; a owl:Class ; rdfs:label "Atrophic pituitary gland" ; rdfs:subClassOf obo:HP_0012506 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001623 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000007 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410280 obo:IAO_0000115 "Onset of disease manifestations before adulthood, defined here as before the age of 16 years, but excluding neonatal or congenital onset." ; dc:date "2018-11-01T15:27:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Onset before adulthood", "Paediatric onset" ; a owl:Class ; rdfs:label "Pediatric onset" ; rdfs:subClassOf obo:HP_0003674 . obo:HP_0410281 obo:IAO_0000115 "A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur." ; dc:date "2018-11-06T23:08:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Indigestion" ; a owl:Class ; rdfs:label "Dyspepsia" ; rdfs:subClassOf obo:HP_0002027 . obo:HP_0410282 obo:IAO_0000115 "A deviation from the normal concentration of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands." ; dc:date "2018-12-04T01:35:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating amylase level" ; a owl:Class ; rdfs:label "Abnormal circulating amylase concentration" ; rdfs:subClassOf obo:HP_0010876 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000049996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410283 obo:IAO_0000115 "Detection of acetaminophen in the blood." ; dc:date "2018-12-04T01:44:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Positive blood Tylenol test", "Positive blood paracetamol test" ; a owl:Class ; rdfs:label "Positive blood acetaminophen test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0410284 obo:IAO_0000115 "Detection of norpropoxyphene in the blood, a major metabolite of the opioid analgesic drug dextropropoxyphene." ; dc:date "2018-12-04T02:17:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive norpropoxyphene blood test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0410285 obo:IAO_0000115 "Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in meconium." ; dc:date "2018-12-04T02:02:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive meconium methadone test" ; rdfs:subClassOf obo:HP_0500098 . obo:HP_0410286 obo:IAO_0000115 "Detection of molindone in the blood, an antipyschotic used for treatment of schizophrenia." ; dc:date "2018-12-04T02:07:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Positive blood Moban test" ; a owl:Class ; rdfs:label "Positive blood molindone test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0410287 obo:IAO_0000115 "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the intrathoracic or chest region." ; dc:date "2019-01-09T20:07:18Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Chest hemangioma" ; a owl:Class ; rdfs:label "Intrathoracic hemangioma" ; rdfs:subClassOf obo:HP_0001028 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:HP_0001028 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001443 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410288 obo:IAO_0000115 "Increased level of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands." ; dc:date "2019-01-28T20:07:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased circulating amylase level" ; a owl:Class ; rdfs:label "Hyperamylasemia" ; rdfs:subClassOf obo:HP_0410282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000049996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410289 obo:IAO_0000115 "Decreased level of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands." ; dc:date "2019-01-28T20:07:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating amylase level" ; a owl:Class ; rdfs:label "Hypoamylasemia" ; rdfs:subClassOf obo:HP_0410282 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000049996 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410290 obo:IAO_0000115 "Detection of norpropoxyphene in urine." ; dc:date "2019-01-28T20:20:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive urine norpropoxyphene test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0410291 obo:IAO_0000115 "Opposing or not responding to instructions or external stimuli." ; dc:date "2019-01-28T20:32:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Negativism" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0410292 obo:IAO_0000115 "An abnormal level of isohemagglutinin in the blood. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." ; dc:date "2019-01-28T21:28:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal level of natural antibody to blood group agents", "Abnormal natural antibody level to blood group antigens in blood (isohemagglutinin)" ; a owl:Class ; rdfs:label "Abnormal isohemagglutinin level" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0410293 obo:IAO_0000115 "Absent or undetectable level of isohemagglutinin. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." ; dc:date "2019-01-28T21:29:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent natural antibody to blood group agents", "Complete or near-complete absence of isohemagglutinins" ; a owl:Class ; rdfs:label "Absent isohemagglutinin level" ; rdfs:subClassOf obo:HP_0410292 . obo:HP_0410294 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against proteins in vaccines, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:02:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased specific antibody response to protein vaccine" ; rdfs:subClassOf obo:HP_0032140 . obo:HP_0410295 obo:IAO_0000115 "The inability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:02:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Complete or near-complete absence of specific antibody response to tetanus vaccine" ; rdfs:subClassOf obo:HP_0410294 . obo:HP_0410296 obo:IAO_0000115 "The inability to synthesize postvaccination antibodies against a hepatisis B antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:02:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Complete or near-complete absence of specific antibody response to hepatitis B vaccine" ; rdfs:subClassOf obo:HP_0410294 . obo:HP_0410297 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:02:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Partial absence of specific antibody response to tetanus vaccine" ; rdfs:subClassOf obo:HP_0410294 . obo:HP_0410298 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against a hepatitis B antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:02:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Partial absence of specific antibody response to hepatitis B vaccine" ; rdfs:subClassOf obo:HP_0410294 . obo:HP_0410299 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against polysaccharides in vaccines, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:03:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased specific antibody response to polysaccharide vaccine" ; rdfs:subClassOf obo:HP_0032140 . obo:HP_0410300 obo:IAO_0000115 "The inability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:03:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine" ; rdfs:subClassOf obo:HP_0410299 . obo:HP_0410301 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:03:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Partial absence of specific antibody response to unconjugated pneumococcus vaccine" ; rdfs:subClassOf obo:HP_0410299 . obo:HP_0410302 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against protein-conjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:04:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased specific antibody response to protein-conjugated polysaccharide vaccine" ; rdfs:subClassOf obo:HP_0032140 . obo:HP_0410303 obo:IAO_0000115 "The inability to synthesize postvaccination antibodies against a Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:04:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Complete or near-complete absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine" ; rdfs:subClassOf obo:HP_0410302 . obo:HP_0410304 obo:IAO_0000115 "The inability to synthesize postvaccination antibodies against a meningococcus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:04:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Complete or near-complete absence of specific antibody response to meningococcus vaccine" ; rdfs:subClassOf obo:HP_0410302 . obo:HP_0410305 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against a Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:04:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine" ; rdfs:subClassOf obo:HP_0410302 . obo:HP_0410306 obo:IAO_0000115 "A reduced ability to synthesize postvaccination antibodies against a meningococcus antigen, as measured by antibody titer determination following vaccination." ; dc:date "2019-01-28T22:04:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Partial absence of specific antibody response to meningococcus vaccine" ; rdfs:subClassOf obo:HP_0410302 . obo:HP_0410307 obo:IAO_0000115 "Detection of methadone and its metabolites in the stool." ; dc:date "2019-01-28T23:27:34Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive stool methadone test" ; rdfs:subClassOf obo:HP_0500097 . obo:HP_0410308 obo:IAO_0000115 "A reduced ability to synthesize antibodies against antigens from an infectious agent or pathogen (such as bacteria, viruses, parasites, etc.), as measured by antibody titer determination following infection." ; dc:date "2019-01-30T19:50:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased specific antibody response to infection" ; rdfs:subClassOf obo:HP_0012475 . obo:HP_0410309 obo:IAO_0000115 "The concentration of alpha-aminoadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal." ; dcterms:creator ; oboInOwl:hasExactSynonym "2-aminoadipic aciduria" ; a owl:Class ; rdfs:label "Alpha-aminoadipic aciduria" ; rdfs:subClassOf obo:HP_0003215, obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_37024 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410310 obo:IAO_0000115 "An abnormal form or size of neutrophils in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of neutrophil morphology in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormality of neutrophil morphology in CSF" ; rdfs:subClassOf obo:HP_0002921 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410311 obo:IAO_0000115 "Hyposegmented (hypolobulated) or bilobed neutrophil nuclei in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Hyposegmentation of neutrophil nuclei in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Hyposegmentation of neutrophil nuclei in CSF" ; rdfs:subClassOf obo:HP_0410310 . obo:HP_0410312 obo:IAO_0000115 "An excessive division of the lobes of the nucleus of a neutrophil in the cerebrospinal fluid." ; dcterms:creator ; oboInOwl:hasExactSynonym "Hypersegmentation of neutrophil nuclei in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Hypersegmentation of neutrophil nuclei in CSF" ; rdfs:subClassOf obo:HP_0410310 . obo:HP_0410313 obo:IAO_0000115 "Abnormal concentration of 1-methylhistidine in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal urinary 1-methylhistidine concentration" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410314 obo:IAO_0000115 "Decreased concentration of 1-methylhistidine in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary 1-methylhistidine" ; rdfs:subClassOf obo:HP_0410313 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410315 obo:IAO_0000115 "Increased concentration of 1-methylhistidine in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "1-Methylhistidinuria" ; a owl:Class ; rdfs:label "Increased urinary 1-methylhistidine" ; rdfs:subClassOf obo:HP_0410313 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410316 obo:IAO_0000115 "Abnormal amount of 3-methylhistidine in the urine." ; dcterms:creator ; a owl:Class ; rdfs:comment "3-Methylhistidine is an analog of histidine found mainly in skeletal muscle. The rate of myofibrillar protein breakdown may be estimated from the urinary excretion of 3-methylhistidine. This amino acid is formed by the methylation of peptide-bound histidine in actin and myosin, is excreted in the urine when these proteins are broken down, and is not reused for protein synthesis." ; rdfs:label "Abnormal urinary 3-methylhistidine level" ; rdfs:subClassOf obo:HP_0033097 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70959 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410317 obo:IAO_0000115 "Increased concentration of 3-methylhistidine in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "3-Methylhistidinuria" ; a owl:Class ; rdfs:label "Increased urinary 3-methylhistidine" ; rdfs:subClassOf obo:HP_0410316 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70959 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410318 obo:IAO_0000115 "Decreased concentration of 3-methylhistidine in the urine." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased urinary 3-methylhistidine" ; rdfs:subClassOf obo:HP_0410316 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70959 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410319 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against alpha-gal." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to alpha-gal", "Alpha-gal allergy", "IgE-mediated alpha-gal allergy", "Immunoglobulin E-mediated alpha-gal allergy" ; a owl:Class ; rdfs:label "Alpha-gal allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410320 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against animal proteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to animal proteins", "Animal protein allergy", "IgE-mediated animal protein allergy", "Immunoglobulin E-mediated animal protein allergy" ; a owl:Class ; rdfs:label "Animal protein allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410321 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against animal dander." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to animal dander", "Animal dander allergy", "IgE-mediated animal dander allergy", "Immunoglobulin E-mediated animal dander allergy" ; a owl:Class ; rdfs:label "Animal dander allergy" ; rdfs:subClassOf obo:HP_0410320 . obo:HP_0410322 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against bacteria." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to bacteria", "Bacteria allergy", "IgE-mediated bacteria allergy", "Immunoglobulin E-mediated bacteria allergy" ; a owl:Class ; rdfs:label "Bacteria allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410323 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against drugs." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to drugs", "Drug allergy", "IgE-mediated drug allergy", "Immunoglobulin E-mediated drug allergy" ; a owl:Class ; rdfs:label "Drug allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410324 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against dust mites." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0410325" ; oboInOwl:hasExactSynonym "Allergy to dust mites", "Dust mite allergy", "House dust mite allergy", "IgE-mediated dust mite allergy", "Immunoglobulin E-mediated dust mite allergy" ; a owl:Class ; rdfs:label "Dust mite allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410325 obo:IAO_0100001 "HP:0410324" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete House dust mite allergy" ; owl:deprecated true . obo:HP_0410326 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against feathers." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to feathers", "Feather allergy", "IgE-mediated feather allergy", "Immunoglobulin E-mediated feather allergy" ; a owl:Class ; rdfs:label "Feather allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410327 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against dairy." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to dairy", "Dairy allergy", "IgE-mediated dairy allergy", "Immunoglobulin E-mediated dairy allergy" ; a owl:Class ; rdfs:label "Dairy allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410328 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against eggs." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to eggs", "Egg allergy", "IgE-mediated egg allergy", "Immunoglobulin E-mediated egg allergy" ; a owl:Class ; rdfs:label "Egg allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410329 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against gluten." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to gluten", "Gluten allergy", "IgE-mediated gluten allergy", "Immunoglobulin E-mediated gluten allergy" ; a owl:Class ; rdfs:comment "A gluten allergy is usually distinct from gluten sensitivity or Celiac disease." ; rdfs:label "Gluten allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410330 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against allergens contained in meat products." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to meat allergens", "IgE-mediated meat allergen allergy", "Immunoglobulin E-mediated meat allergen allergy", "Meat allergen allergy", "Meat allergy" ; a owl:Class ; rdfs:label "Meat allergen allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410331 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against nut food products." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to nut food products", "IgE-mediated nut food product allergy", "Immunoglobulin E-mediated nut food product allergy", "Nut allergy", "Nut food product allergy" ; a owl:Class ; rdfs:label "Nut food product allergy" ; rdfs:subClassOf obo:HP_0410332 . obo:HP_0410332 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against plant based food allergens." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to plant based food allergens", "IgE-mediated plant based food allergen allergy", "Immunoglobulin E-mediated plant based food allergen allergy", "Plant based food allergy" ; a owl:Class ; rdfs:label "Plant based food allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410333 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against seafood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to seafood", "IgE-mediated seafood allergy", "Immunoglobulin E-mediated seafood allergy", "Seafood allergy" ; a owl:Class ; rdfs:label "Seafood allergy" ; rdfs:subClassOf obo:HP_0500093 . obo:HP_0410334 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against fungus." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to fungi", "Fungal allergy", "Fungi allergy", "Fungus allergy", "IgE-mediated fungi allergy", "Immunoglobulin E-mediated fungi allergy" ; a owl:Class ; rdfs:label "Fungi allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410335 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against insects." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to insects", "IgE-mediated insect allergy", "Immunoglobulin E-mediated insect allergy", "Insect allergy" ; a owl:Class ; rdfs:label "Insect allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410336 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against insect venom." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to venom", "IgE-mediated venom allergy", "Immunoglobulin E-mediated venom allergy", "Venom allergy" ; a owl:Class ; rdfs:label "Venom allergy" ; rdfs:subClassOf obo:HP_0410335 . obo:HP_0410337 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against parasites." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to parasites", "IgE-mediated parasite allergy", "Immunoglobulin E-mediated parasite allergy", "Parasite allergy" ; a owl:Class ; rdfs:label "Parasite allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410338 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against plant products." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to plant products", "IgE-mediated plant product allergy", "Immunoglobulin E-mediated plant product allergy", "Plant product allergy" ; a owl:Class ; rdfs:label "Plant product allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0410339 obo:IAO_0000115 "Hypersensitivity in form of an adverse immune reaction against insect bites." ; dcterms:creator ; oboInOwl:hasExactSynonym "Allergy to insect bites", "IgE-mediated insect bite allergy", "Immunoglobulin E-mediated insect bite allergy", "Insect bite allergy" ; a owl:Class ; rdfs:label "Insect bite allergy" ; rdfs:subClassOf obo:HP_0410335 . obo:HP_0410340 obo:IAO_0000115 "The occurrence of multiple or unique whitish or normal in color small papules or nodules in oral cavity, especially on labial and buccal mucosa, lower lip and tongue, and less often on the upper lip, gingiva and palate." ; dcterms:creator ; oboInOwl:hasExactSynonym "Focal epithelial hyperplasia of the lining of mouth", "Oral mucosa epithelial hyperplasia" ; a owl:Class ; rdfs:label "Focal epithelial hyperplasia of oral mucosa" ; rdfs:subClassOf obo:HP_0011830 . obo:HP_0410341 obo:IAO_0000115 "An abnormal level of heparan sulfate in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating heparan sulphate level", "Abnormality of the concentration of heparan sulfate in the blood", "Abnormality of the concentration of heparan sulphate in the blood" ; a owl:Class ; rdfs:label "Abnormal circulating heparan sulfate level" ; rdfs:subClassOf obo:HP_0011013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28815 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410342 obo:IAO_0000115 "An abnormal increase in the concentration of heparan sulfate in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased blood heparan sulfate concentration", "Increased blood heparan sulphate concentration", "Increased circulating heparan sulphate level" ; a owl:Class ; rdfs:label "Increased circulating heparan sulfate level" ; rdfs:subClassOf obo:HP_0410341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28815 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410343 obo:IAO_0000115 "An abnormal decrease in the concentration of heparan sulfate in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood heparan sulfate concentration", "Decreased blood heparan sulphate concentration", "Decreased circulating heparan sulphate level" ; a owl:Class ; rdfs:label "Decreased circulating heparan sulfate level" ; rdfs:subClassOf obo:HP_0410341 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28815 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410344 obo:IAO_0000115 "Decreased length of O-fucosylated glycans present on properdin." ; dcterms:creator ; oboInOwl:hasExactSynonym "Presence of terminal O-fucose glycans on properdin" ; a owl:Class ; rdfs:label "Shortened O-fucosylated glycan on properdin" ; rdfs:subClassOf obo:HP_0012359 . obo:HP_0410345 obo:IAO_0000115 "An abnormal increase in the concentration of polyhexose in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased polyhexose concentration in urine" ; a owl:Class ; rdfs:label "Increased urinary polyhexose" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0410346 obo:IAO_0000115 "An abnormal increase in the concentration of galactosylated oligosaccharides in urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased concentration of galactosylated oligosaccharides in urine" ; a owl:Class ; rdfs:label "Increased urinary galactosylated oligosaccharide" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0410347 obo:IAO_0000115 "An abnormal increase in the concentration of high-mannose-type oligosaccharides in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased concentration of high-mannose-type oligosaccharides in urine" ; a owl:Class ; rdfs:label "Increased urinary high-mannose-type oligosaccharide" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0410348 obo:IAO_0000115 "An abnormal increase in the concentration of multiantennary sialylated oligosaccharides in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increase concentration of multiantennary sialylated oligosaccharides in urine" ; a owl:Class ; rdfs:label "Increased urinary multiantennary sialylated oligosaccharide" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0410349 obo:IAO_0000115 "An abnormal decrease in glycosyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase enzymatic level." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased glycosyltransferase O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0410350 obo:IAO_0000115 "An abnormal increase in the concentrationl of small fucosylated oligosaccharides in the urine." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased concentration of fucosylated oligosaccharides in urine" ; a owl:Class ; rdfs:label "Increased urinary fucosylated oligosaccharide" ; rdfs:subClassOf obo:HP_0010471 . obo:HP_0410351 obo:IAO_0000115 "An abnormal concentration of complex N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal concentration of complex N-glycans on glycoproteins" ; a owl:Class ; rdfs:label "Abnormal complex N-glycan level" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0410352 obo:IAO_0000115 "An abnormal increase in the concentration of complex N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased concentration of complex N-glycans on glycoproteins" ; a owl:Class ; rdfs:label "Increased complex N-glycan level" ; rdfs:subClassOf obo:HP_0410351 . obo:HP_0410353 obo:IAO_0000115 "An abnormal decrease in the concentration of complex N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased truncated complex N-glycans on glycoproteins" ; a owl:Class ; rdfs:label "Decreased complex N-glycan level" ; rdfs:subClassOf obo:HP_0410351 . obo:HP_0410354 obo:IAO_0000115 "An abnormal increase in the concentration of sialylated N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased concentration of sialylated N-glycans on glycoproteins" ; a owl:Class ; rdfs:label "Increased sialylated N-glycan level" ; rdfs:subClassOf obo:HP_0012349 . obo:HP_0410355 obo:IAO_0000115 "An abnormal decrease in the concentration of sialylated N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased concentration of sialylated N-glycans on glycoproteins" ; a owl:Class ; rdfs:label "Decreased sialylated N-glycan level" ; rdfs:subClassOf obo:HP_0012349 . obo:HP_0410356 obo:IAO_0000115 "An abnormal concentration of high-mannose N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal high-mannose N-glycans on glycoprotein concentration" ; a owl:Class ; rdfs:label "Abnormal high-mannose N-glycan level" ; rdfs:subClassOf obo:HP_0012347 . obo:HP_0410357 obo:IAO_0000115 "An abnormal increase in the concentration of high-mannose N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased high-mannose N-glycans on glycoprotein concentration" ; a owl:Class ; rdfs:label "Increased high-mannose N-glycan level" ; rdfs:subClassOf obo:HP_0410356 . obo:HP_0410358 obo:IAO_0000115 "An abnormal decrease in the concentration of high-mannose N-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased high-mannose N-glycans on glycoprotein concentration" ; a owl:Class ; rdfs:label "Decreased high-mannose N-glycan level" ; rdfs:subClassOf obo:HP_0410356 . obo:HP_0410359 obo:IAO_0000115 "An abnormal in the concentration of core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal concentration of T-antigen" ; a owl:Class ; rdfs:label "Abnormal core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0012358 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_546807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410360 obo:IAO_0000115 "An abnormal increase in the concentration of core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased T-antigen concentration" ; a owl:Class ; rdfs:label "Increased core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0410359 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_546807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410361 obo:IAO_0000115 "An abnormal decrease in the concentration of core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased T-antigen concentration" ; a owl:Class ; rdfs:label "Decreased core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0410359 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_546807 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410362 obo:IAO_0000115 "Hypoglycosylation of alpha-dystroglycan with O-mannosyl glycans. Alpha-dystroglycan is a functional target of O-mannosyl glycosylation and functional glycosylation of alpha-DG is essential in its interaction with the extracellular matrix." ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced O-mannosyl glycans on alpha-dystroglycan" ; a owl:Class ; rdfs:label "Decreased O-mannosyl glycans on alpha-dystroglycan" ; rdfs:subClassOf obo:HP_0012358 . obo:HP_0410363 obo:IAO_0000115 "An abnormal increase in the concentration of monosialylated core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased sialyl T-antigen concentration" ; a owl:Class ; rdfs:label "Increased monosialylated core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0012362 . obo:HP_0410364 obo:IAO_0000115 "An abnormal decrease in the concentration of monosialylated core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased sialyl T-antigen concentration" ; a owl:Class ; rdfs:label "Decreased monosialylated core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0012362 . obo:HP_0410365 obo:IAO_0000115 "An abnormal increase in the concentration of disialylated core 1 O-glycans on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased disialyl T-antigen concentration" ; a owl:Class ; rdfs:label "Increased disialylated core 1 O-glycan level" ; rdfs:subClassOf obo:HP_0012362 . obo:HP_0410366 obo:IAO_0000115 "An abnormal increase in the concentration of globoside Gb4." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased globoside Gb4 concentration" ; a owl:Class ; rdfs:label "Increased globoside Gb4 level" ; rdfs:subClassOf obo:HP_0004343 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_84125 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410367 obo:IAO_0000115 "An abnormally increased level of immunoglobulin against hepatitis A virus in the blood." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased hepatitis A virus antibody level" ; rdfs:subClassOf obo:HP_0010702 . obo:HP_0410368 obo:IAO_0000115 "An abnormal increase in the concentration of glycolipid globoside Gb3." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased globoside Gb3 concentration" ; a owl:Class ; rdfs:label "Increased globoside Gb3 level" ; rdfs:subClassOf obo:HP_0004343 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_84690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410369 obo:IAO_0000115 "An abnormally increased level of immunoglobulin against hepatitis B virus in the blood." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased hepatitis B virus antibody level" ; rdfs:subClassOf obo:HP_0010702 . obo:HP_0410370 obo:IAO_0000115 "The absence of ganglioside GM3." ; dcterms:creator ; a owl:Class ; rdfs:label "Absence of ganglioside GM3" ; rdfs:subClassOf obo:HP_0004343 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CHEBI_84118 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410371 obo:IAO_0000115 "An abnormally increased level of immunoglobulin against hepatitis C virus in the blood." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased hepatitis C virus antibody level" ; rdfs:subClassOf obo:HP_0010702 . obo:HP_0410372 obo:IAO_0000115 "An abnormal increase in the concentration of Tn antigen on glycoproteins." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased O-GalNac on glycoprotein concentration" ; a owl:Class ; rdfs:label "Increased Tn-antigen level" ; rdfs:subClassOf obo:HP_0012358 . obo:HP_0410373 obo:IAO_0000115 "Any abnormality in the proportion of naive CD4 T cells relative to the total number of T cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of CD4+CD45RA+ cells", "Abnormal proportion of naive thymus-derived CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Abnormal proportion of naive CD4 T cells" ; rdfs:subClassOf obo:HP_0031392, obo:HP_0031396 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000895 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410374 obo:IAO_0000115 "Any abnormality in the proportion of naive CD8 T cells relative to the total number of T cells." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of naive CD8 T cells" ; rdfs:subClassOf obo:HP_0031396 . obo:HP_0410375 dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of naive CD4 T cells", "Increased proportion of CD4+CD45RA+ cells", "Increased proportion of naive thymus-derived CD4-positive, alpha-beta T cells" ; a owl:Class ; rdfs:comment "An abnormally increased proportion of naive CD4 T cells relative to the total number of T cells." ; rdfs:label "Increased proportion of naive CD4 T cells" ; rdfs:subClassOf obo:HP_0031398, obo:HP_0032219, obo:HP_0410373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000895 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410376 obo:IAO_0000115 "An abnormally increased proportion of naive CD8 T cells relative to the total number of T cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of naive CD8 T cells", "Elevated proportion of naive thymus-derived CD8-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Increased proportion of naive CD8 T cells" ; rdfs:subClassOf obo:HP_0031398 . obo:HP_0410377 obo:IAO_0000115 "An abnormally reduced proportion of naive CD8 T cells relative to the total number of T cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Reduced proportion of naive CD8 T cells", "Reduced proportion of naive thymus-derived CD8-positive, alpha-beta T cells" ; a owl:Class ; rdfs:label "Decreased proportion of naive CD8 T cells" ; rdfs:subClassOf obo:HP_0031397 . obo:HP_0410378 obo:IAO_0000115 "An abnormally reduced proportion of naive CD4 T cells relative to the total number of T cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+CD45RA+ cells", "Decreased proportion of naive thymus-derived CD4-positive, alpha-beta T cells", "Reduced proportion of naive CD4 T cells" ; a owl:Class ; rdfs:label "Decreased proportion of naive CD4 T cells" ; rdfs:subClassOf obo:HP_0410373 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000895 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410379 obo:IAO_0000115 "An abnormal proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of CD4-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0031392, obo:HP_0032182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410380 obo:IAO_0000115 "An abnormal proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:comment "Human CD8+T cells are commonly classified into four subsets based on the surface expression of the leukocyte common antigen isoform CD45RA and the lymph node addressin CCR7. Thereby, naive TN cells (CD45RA+/CCR7+) are separated from central memory TCM (CD45RA-/CCR7+), effector memory TEM (CD45RA-/CCR7-) and TEMRA (CD45RA+/CCR7-) T cells." ; rdfs:label "Abnormal proportion of CD8-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0031393, obo:HP_0032182 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410381 obo:IAO_0000115 "An abnormal proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of central memory CD4-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410379 . obo:HP_0410382 obo:IAO_0100001 obo:HP_0025623 ; a owl:Class ; rdfs:comment "This term was a duplicate, hence it was obsoleted. https://github.com/obophenotype/human-phenotype-ontology/issues/5696" ; rdfs:label "obsolete Abnormal proportion of effector memory CD4-positive, alpha-beta T cells" ; owl:deprecated true . obo:HP_0410383 obo:IAO_0000115 "An abnormal proportion of effector memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of effector memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410384 obo:IAO_0000115 "An abnormal proportion of central memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of central memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000907 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410385 obo:IAO_0000115 "Decreased proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased proportion of CD8-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0032183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410386 obo:IAO_0000115 "Decresaed proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased proportion of CD4-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0032183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410387 obo:IAO_0100001 "HP:0025624" ; a owl:Class ; rdfs:comment "This term was a duplicate, hence it was obsoleted. https://github.com/obophenotype/human-phenotype-ontology/issues/5696" ; rdfs:label "obsolete Decreased proportion of effector memory CD4-positive, alpha-beta T cells" ; owl:deprecated true . obo:HP_0410388 obo:IAO_0000115 "A reduced proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0025622" ; oboInOwl:hasExactSynonym "Decreased proportion of CD4+ central memory cells", "Decreased proportion of CD4-positive central memory cells", "Decreased proportion of central memory CD4+, alpha-beta T cell", "Reduced proportion of CD4+ central memory cells" ; a owl:Class ; rdfs:comment "An abnormally decreased proportion of central memory CD4+ T cells. These are memory cells that are located in the secondary lymphoid organs. These cells may have a CD3/CD4/CD62L+/CD45RA- phenotype." ; rdfs:label "Decreased proportion of central memory CD4-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410386 . obo:HP_0410389 obo:IAO_0000115 "A reduced proportion of CD8-positive, alpha-beta central memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased proportion of central memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410384, obo:HP_0410385 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000907 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410390 obo:IAO_0000115 "A reduced proportion of CD8-positive, alpha-beta effector memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased proportion of effector memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410383, obo:HP_0410385 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410391 obo:IAO_0000115 "An abnormally elevated proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of CD4-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0032184, obo:HP_0032219, obo:HP_0410379 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410392 obo:IAO_0000115 "An abnormally elevated proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of CD8-positive, alpha-beta memory T cells" ; rdfs:subClassOf obo:HP_0032184, obo:HP_0410380 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410393 obo:IAO_0000115 "An abnormally elevated proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0025621" ; oboInOwl:hasExactSynonym "Elevated proportion central memory CD4-positive, alpha-beta T cells", "Elevated proportion of CD4+ central memory cells", "Increased proportion of CD4+ central memory cells", "Increased proportion of central memory CD4+, alpha-beta T cell" ; a owl:Class ; rdfs:comment "These are memory cells that are located in the secondary lymphoid organs. These cells may have a CD3/CD4/CD62L+/CD45RA- phenotype." ; rdfs:label "Increased proportion of central memory CD4-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410391 . obo:HP_0410394 obo:IAO_0000115 "An abnormally elevated proportion of effector memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of effector memory CD4-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410391 . obo:HP_0410395 obo:IAO_0000115 "An increased proportion of effector memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of effector memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410396 obo:IAO_0000115 "An increased proportion of central memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." ; dcterms:creator ; a owl:Class ; rdfs:label "Increased proportion of central memory CD8-positive, alpha-beta T cells" ; rdfs:subClassOf obo:HP_0410384, obo:HP_0410392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000907 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410397 obo:IAO_0000115 "Saccular dilatation of the terminal bronchioles." ; dcterms:creator ; oboInOwl:hasExactSynonym "Bronchiolectasia" ; a owl:Class ; rdfs:label "Bronchiolectasis" ; rdfs:subClassOf obo:HP_0025426 . obo:HP_0410399 obo:IAO_0000115 "Detection of lead in the blood." ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased blood lead level" ; a owl:Class ; rdfs:label "Positive blood lead test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0410400 obo:IAO_0000115 "Absence of the sebaceous gland, the holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts." ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence of sebaceous glands" ; a owl:Class ; rdfs:label "Absent sebaceous glands" ; rdfs:subClassOf obo:HP_0032226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001821 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0410401 obo:IAO_0000115 "Applies to a sign or symptom that is exacerbated in the evening as compared to the day." ; dcterms:creator ; a owl:Class ; rdfs:label "Worse in evening" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_0430000 obo:IAO_0000115 "An abnormality of the frontal bone." ; oboInOwl:hasDbXref "UMLS:C4021873" ; oboInOwl:hasExactSynonym "Abnormality of the bone of the forehead", "Abnormality of the frontal bone" ; oboInOwl:hasNarrowSynonym "Abnormal morphology of frontal bone", "Anomaly of the frontal bone", "Deformity of the frontal bone", "Malformation of the frontal bone" ; a owl:Class ; rdfs:label "Abnormal frontal bone morphology" ; rdfs:subClassOf obo:HP_0002683 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430002 obo:IAO_0000115 "An abnormality of the lacrimal bone." ; oboInOwl:hasDbXref "UMLS:C4021872" ; oboInOwl:hasNarrowSynonym "Anomaly of the lacrimal bone", "Deformity of the lacrimal bone", "Malformation of the lacrimal bone" ; a owl:Class ; rdfs:label "Abnormal lacrimal bone morphology" ; rdfs:subClassOf obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001680 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430003 obo:IAO_0000115 "An abnormality of the palatine bone." ; oboInOwl:hasDbXref "UMLS:C4021871" ; oboInOwl:hasExactSynonym "Abnormality of the palatine bone" ; oboInOwl:hasNarrowSynonym "Anomaly of the palatine bone", "Deformity of the palatine bone", "Malformation of the palatine bone" ; a owl:Class ; rdfs:label "Abnormal palatine bone morphology" ; rdfs:subClassOf obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001682 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430004 oboInOwl:hasDbXref "UMLS:C4021870" ; a owl:Class ; rdfs:label "Frontomalar faciosynostosis" ; rdfs:subClassOf obo:HP_0011821 . obo:HP_0430005 obo:IAO_0000115 "An abnormality of the ethmoid bone" ; oboInOwl:hasDbXref "UMLS:C4021869" ; oboInOwl:hasExactSynonym "Abnormality of ethmoid bone" ; oboInOwl:hasNarrowSynonym "Anomaly of the ethmoid bone", "Deformity of the ethmoid bone", "Malformation of the ethmoid bone" ; a owl:Class ; rdfs:label "Abnormal ethmoid bone morphology" ; rdfs:subClassOf obo:HP_0011821 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430006 obo:IAO_0000115 "An eyelash that emerges from the underside (conjunctiva) of the upper or lower eyelid." ; oboInOwl:hasDbXref "SNOMEDCT_US:95504004", "UMLS:C0521574" ; a owl:Class ; rdfs:label "Ectopic cilia of eyelid" ; rdfs:subClassOf obo:HP_0000499 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000628 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001702 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430007 obo:IAO_0000115 "A partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball." ; oboInOwl:hasDbXref "SNOMEDCT_US:90216006", "UMLS:C0152454" ; oboInOwl:hasExactSynonym "Eyelid adhesion to globe of eye", "Eyelid stuck to eyeball" ; a owl:Class ; rdfs:label "Symblepharon" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0430008 obo:IAO_0000115 "The presence of more than the normal number of eyelids." ; oboInOwl:hasDbXref "SNOMEDCT_US:24606006", "UMLS:C0266576", "UMLS:C4280275" ; oboInOwl:hasExactSynonym "Extra eyelid" ; oboInOwl:hasNarrowSynonym "Double eyelid" ; a owl:Class ; rdfs:label "Accessory eyelid" ; rdfs:subClassOf obo:HP_0000492 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430009 obo:IAO_0000115 "Developmental hypoplasia of the eyelid." ; oboInOwl:hasBroadSynonym "Small eyelid" ; oboInOwl:hasDbXref "SNOMEDCT_US:204203001", "UMLS:C0344499", "UMLS:C4280274" ; oboInOwl:hasExactSynonym "Decreased size of eyelid", "Hypoplasia of the eyelid", "Hypoplastic eyelid", "Underdevelopment of eyelid" ; oboInOwl:hasNarrowSynonym "Short eyelid" ; a owl:Class ; rdfs:label "Hypoplasia of eyelid" ; rdfs:subClassOf obo:HP_0011226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430010 obo:IAO_0000115 "Abnormal shortness of the vertical dimensions of the eyelids." ; oboInOwl:hasDbXref "SNOMEDCT_US:94684003", "UMLS:C0685873" ; oboInOwl:hasExactSynonym "Abnormally small eyelid" ; a owl:Class ; rdfs:label "Microblepharia" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0430011 obo:IAO_0000115 "An abnormality of the palpebral conjunctiva." ; oboInOwl:hasDbXref "UMLS:C4021868" ; a owl:Class ; rdfs:label "Defect of palpebral conjunctiva" ; rdfs:subClassOf obo:HP_0000502 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001812 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430012 obo:IAO_0000115 "Failure to complete ossification (maturation and calcification) of the palatine bone." ; oboInOwl:hasDbXref "SNOMEDCT_US:93595006", "UMLS:C0685213" ; oboInOwl:hasNarrowSynonym "Incomplete calcification of palatine bone", "Incomplete mineralization of palatine bone" ; oboInOwl:hasRelatedSynonym "Incomplete formation of palatine bone" ; a owl:Class ; rdfs:label "Incomplete ossification of palatine bone" ; rdfs:subClassOf obo:HP_0430003 . obo:HP_0430013 obo:IAO_0000115 "Lack of formation of the palatine bone." ; oboInOwl:hasDbXref "UMLS:C4021867" ; oboInOwl:hasNarrowSynonym "Absence of palatine bone calcification", "Absence of palatine bone mineralization" ; oboInOwl:hasRelatedSynonym "Absence of palatine bone formation" ; a owl:Class ; rdfs:label "Absent palatine bone ossification" ; rdfs:subClassOf obo:HP_0430003 ; owl:equivalentClass _:genid105653 . obo:HP_0430014 obo:IAO_0000115 "An abnormality of one or more of the five muscles of the soft palate." ; oboInOwl:hasDbXref "UMLS:C4073196" ; oboInOwl:hasExactSynonym "Abnormality of soft palate muscles" ; a owl:Class ; rdfs:label "Abnormality of musculature of soft palate" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0100736 . obo:HP_0430015 obo:IAO_0000115 "An abnormality of any of the muscles of the pharynx." ; oboInOwl:hasDbXref "UMLS:C4073197" ; oboInOwl:hasExactSynonym "Abnormality of muscles of the pharynx", "Abnormality of musculature of pharynx", "Abnormality of pharyngeal musculature", "Abnormality of pharynx musculature" ; a owl:Class ; rdfs:label "Abnormal morphology of musculature of pharynx" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430016 obo:IAO_0000115 "An abnormality of the tensor veli palatini muscle" ; oboInOwl:hasDbXref "UMLS:C4073198" ; a owl:Class ; rdfs:label "Abnormality of tensor veli palatini muscle" ; rdfs:subClassOf obo:HP_0430014 . obo:HP_0430017 obo:IAO_0000115 "An abnormality of the uvular muscle" ; oboInOwl:hasDbXref "UMLS:C4073199" ; oboInOwl:hasExactSynonym "Abnormality of musculus uvulae" ; a owl:Class ; rdfs:label "Abnormality of uvular muscle" ; rdfs:subClassOf obo:HP_0000172, obo:HP_0430014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010235 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430018 obo:IAO_0000115 "An abnormality of the muscles of the structure of the nose." ; oboInOwl:hasDbXref "UMLS:C4073200" ; oboInOwl:hasExactSynonym "Abnormality of muscle of nose", "Abnormality of musculature of the nose", "Abnormality of nasal musculature" ; a owl:Class ; rdfs:label "Abnormality of nasal musculature" ; rdfs:subClassOf obo:HP_0000301 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008522 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430019 obo:IAO_0000115 "An abnormality of any of the muscles of facial expression, which are innervated by the seventh (VII) cranial nerve and control facial expression." ; oboInOwl:hasDbXref "UMLS:C4073201" ; oboInOwl:hasExactSynonym "Abnormality of muscle of facial expression", "Abnormality of musculature of facial expression" ; a owl:Class ; rdfs:label "Abnormality of muscle of facial expression" ; rdfs:subClassOf obo:HP_0000301 . obo:HP_0430020 obo:IAO_0000115 "An abnormality of the levator labii superioris alaeque nasi muscle." ; oboInOwl:hasDbXref "UMLS:C4073202" ; a owl:Class ; rdfs:label "Abnormality of levator labii superioris alaeque nasi muscle" ; rdfs:subClassOf obo:HP_0430019 . obo:HP_0430021 obo:IAO_0000115 "An abnormality of the common carotid arteries, which provide the arterial supply to the head and neck and give rise to the internal carotid artery and the external carotid artery." ; oboInOwl:hasDbXref "UMLS:C4073203" ; oboInOwl:hasExactSynonym "Abnormality of the common carotid artery" ; a owl:Class ; rdfs:label "Abnormal common carotid artery morphology" ; rdfs:subClassOf obo:HP_0005344 . obo:HP_0430022 obo:IAO_0000115 "An abnormality of the sphenoid sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The sphenoid sinus is located within the sphenoid bone." ; oboInOwl:hasDbXref "UMLS:C4073204" ; oboInOwl:hasExactSynonym "Abnormality of the sphenoidal sinus" ; a owl:Class ; rdfs:label "Abnormality of the sphenoid sinus" ; rdfs:subClassOf obo:HP_0000245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001724 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430023 obo:IAO_0000115 "An abnormality of the maxillary sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The maxillary sinus is located within the skeleton of the midface, lateral to the nasal cavity." ; oboInOwl:hasDbXref "UMLS:C4073205" ; oboInOwl:hasExactSynonym "Abnormality of the antrum of Highmore", "Abnormality of the maxillary antrum", "Abnormality of the upper jaw sinus" ; a owl:Class ; rdfs:label "Abnormality of the maxillary sinus" ; rdfs:subClassOf obo:HP_0000245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001764 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430024 obo:IAO_0000115 "An abnormality of an external jugular vein of the neck." ; oboInOwl:hasDbXref "UMLS:C4073206" ; a owl:Class ; rdfs:label "Abnormality of external jugular vein" ; rdfs:subClassOf obo:HP_3000042 . obo:HP_0430025 obo:IAO_0000115 "Two-sided or bilateral weakness of the muscles of facial expression and eye closure." ; oboInOwl:hasDbXref "UMLS:C4073207" ; oboInOwl:hasExactSynonym "Bilateral facial muscle paralysis", "Bilateral facial muscle weakness", "Bilateral facial paralysis", "Paralysis of both sides of the face", "Weakness of both sides of the face" ; a owl:Class ; rdfs:label "Bilateral facial palsy" ; rdfs:subClassOf obo:HP_0010628 . obo:HP_0430026 obo:IAO_0100001 "HP:0000309" ; a owl:Class ; rdfs:label "obsolete Abnormality of the shape of the midface" ; owl:deprecated true . obo:HP_0430028 obo:IAO_0000115 "Abnormally increased dimension of the maxilla, especially relative to the mandible, resulting in a malocclusion or malalignment between the upper and lower teeth or in anterior positioning of the nasal base, increased convexity of the face, increased nasolabial angle, or increased width (transverse dimension of the maxilla." ; oboInOwl:hasDbXref "SNOMEDCT_US:28070007", "UMLS:C0266081", "UMLS:C2227090", "UMLS:C4073209", "UMLS:C4280272", "UMLS:C4280273" ; oboInOwl:hasExactSynonym "Big maxilla", "Big upper jaw", "Hyperplasia of upper jaw", "Increased size of maxilla", "Increased size of upper jaw", "Large maxilla", "Large upper jaw", "Maxillary excess", "Maxillary hyperplasia", "Maxillary macrognathia", "Maxillary prominence", "Prominent maxilla", "Prominent upper jaw", "Upper jaw bone excess", "Upper jaw excess" ; oboInOwl:hasNarrowSynonym "Increased projection of maxilla", "Increased projection of upper jaw" ; oboInOwl:hasRelatedSynonym "Hypertrophy of maxilla", "Hypertrophy of upper jaw", "Maxillary prognathia", "Prognathia of the upper jaw" ; a owl:Class ; rdfs:label "Hyperplasia of the maxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0430029 obo:IAO_0000115 "An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively large in size compared to the other parts of the maxilla or other facial structures." ; oboInOwl:hasDbXref "UMLS:C4073210" ; oboInOwl:hasExactSynonym "Hyperplasia of the intermaxillary bone", "Hyperplasia of the primary palate bone", "Increased size of premaxilla", "Increased size of the primary palate bone", "Large premaxilla", "Large primary palate bone", "Premaxillary excess", "Primary palate bone excess" ; a owl:Class ; rdfs:label "Hyperplasia of the premaxilla" ; rdfs:subClassOf obo:HP_0010758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000644 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500001 obo:IAO_0000115 "A perceived unpleasant smell given off by the body." ; oboInOwl:hasExactSynonym "BO", "Body odor", "Body odour", "Bromhidrosis", "Bromidrosis", "Osmidrosis" ; a owl:Class ; rdfs:label "Body odor" ; rdfs:subClassOf obo:HP_0025142 . obo:HP_0500005 obo:IAO_0000115 "Pain in and around the anus or rectum (perianal region)." ; oboInOwl:hasExactSynonym "Anal pain", "Rectal pain" ; a owl:Class ; rdfs:label "Anal pain" ; rdfs:subClassOf obo:HP_0012531 . obo:HP_0500006 obo:IAO_0000115 "Inflammation of the urethra." ; a owl:Class ; rdfs:comment "Urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be asymptomatic. Common etiologies include gonococcal urethritis as well as infection by chlamydia trachomatis, mycoplasma genitalium, ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus, and adenovirus." ; rdfs:label "Urethritis" ; rdfs:subClassOf obo:HP_0000795 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500007 obo:IAO_0000115 "Multiple cysts along the pupillary margin that appear as spherical or tear-drop-shaped pigmented lesions or wrinkled masses emerging from the pupillary border of the iris." ; a owl:Class ; rdfs:comment "Iris flocculi cause little, if any, visual impairment in most cases. However, they are occasionally associated with dissecting aortic aneurysm due to a shared mutation in smooth muscle that affects both the iris and the aorta." ; rdfs:label "Iris flocculi" ; rdfs:subClassOf obo:HP_0000525 . obo:HP_0500008 obo:IAO_0000115 "Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea." ; oboInOwl:hasExactSynonym "Vortex keratopathy" ; a owl:Class ; rdfs:comment "Cornea verticillata can be a feature of Fabry disease and can occur as an adverse effect of mediciations including amiodarone." ; rdfs:label "Cornea verticillata" ; rdfs:subClassOf obo:HP_0000481 . obo:HP_0500009 obo:IAO_0000115 "It is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum." ; oboInOwl:hasRelatedSynonym "LDD", "Lhermitte-Duclos disease" ; a owl:Class ; rdfs:comment "Often associated with Cowden syndrome." ; rdfs:label "Dysplastic gangliocytoma of the cerebellum" ; rdfs:subClassOf obo:HP_0001317 . obo:HP_0500010 obo:IAO_0100001 "HP:0031211" ; a owl:Class ; rdfs:label "obsolete Increased cholesterol esters" ; owl:deprecated true . obo:HP_0500011 obo:IAO_0000115 "A rounded, puffy face with fat deposits in the temporal fossa and cheeks, a double chin." ; oboInOwl:hasExactSynonym "Moon face", "Puffy face", "Puffy facies" ; a owl:Class ; rdfs:comment "Moon facies can occur in persons treated with high-dose corticosteroids or with Cushing disease." ; rdfs:label "Moon facies" ; rdfs:subClassOf obo:HP_0001999 . obo:HP_0500012 obo:IAO_0000115 "A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone (GnRH). Intermittent GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH)." ; oboInOwl:hasExactSynonym "Abnormality of GnRH level", "Abnormality of gonadotropin-releasing hormone level" ; a owl:Class ; rdfs:label "Abnormal gonadotropin-releasing hormone concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_5520 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500013 obo:IAO_0000115 "Secretion of gonadotropin-releasing hormone that does not occur in a pulsatile fashion." ; oboInOwl:hasExactSynonym "Absence of GnRH pulsatility" ; a owl:Class ; rdfs:comment "The decapeptide gonadotropin-releasing hormone (GnRH) is the master hormone regulating reproduction. GnRH is released from some 1000 neurons within the hypothalamus in a pulsatile manner. Hypothalamic GnRH gene expression occurs intermittently (in a pulsatile fashion). The primary target of hypothalamic GnRH is the anterior pituitary gonadotrope, which responds to stimulation by increasing the synthesis and secretion of the gonadotropins luteinzing hormone (LH) and follicle stimulating hormone (FSH), which in turn regulate gonadal development and function." ; rdfs:label "Lack of gonadotropin-releasing hormone pulsatility" ; rdfs:subClassOf obo:HP_0500012 . obo:HP_0500014 oboInOwl:consider "HP:0000118" ; a owl:Class ; rdfs:label "obsolete Abnormal test result" ; owl:deprecated true . obo:HP_0500015 obo:IAO_0000115 "Abnormal test result of cardiovascular physiology." ; dc:date "2017-05-12T16:23:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiac test" ; rdfs:subClassOf obo:HP_0001626 . obo:HP_0500016 obo:IAO_0000115 "Abnormal results of a MRI for the heart." ; dc:date "2017-05-12T16:33:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cardiac magnetic resonance imaging", "Abnormal heart MRI" ; a owl:Class ; rdfs:label "Abnormal cardiac MRI" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0500017 obo:IAO_0000115 "Abnormal results from the diagnostic tests resulting from cardiac catheterization." ; dc:date "2017-05-12T16:36:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal cardiac cath" ; a owl:Class ; rdfs:label "Abnormal cardiac catheterization" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0500018 obo:IAO_0000115 "Abnormal results of exercise on heart function." ; dc:date "2017-05-12T16:41:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasBroadSynonym "Abnormal exercise test" ; oboInOwl:hasExactSynonym "Abnormal cardiac exercise test", "Abnormal treadmill test" ; a owl:Class ; rdfs:label "Abnormal cardiac exercise stress test" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0500019 obo:IAO_0000115 "Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2)." ; dc:date "2017-05-12T16:49:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal metabolic cart test" ; a owl:Class ; rdfs:label "Abnormal resting energy expenditure from metabolic cart test" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0500020 obo:IAO_0000115 "Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes." ; dc:date "2017-05-12T16:54:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiac biomarker test" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0500021 obo:IAO_0000115 "An decreased level of gamma-aminobutyric acid in the brain identified by magnetic resonance spectroscopy (MRS)." ; dc:date "2017-05-18T19:29:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced brain gamma-aminobutyric acid level by MRS" ; rdfs:subClassOf obo:HP_0012705 . obo:HP_0500022 obo:IAO_0000115 "A deviation from the normal concentration of dehydroepiandrosterone in the circulation." ; dc:date "2017-05-18T19:38:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serum DHEA", "Abnormal serum androstenolone level", "Abnormal serum dehydroepiandrosterone level" ; a owl:Class ; rdfs:comment "Dehydroepiandrosterone (DHEA), which is produced in the adrenal glands and the gonads, represents the most abundant circulating steroid hormone. It is a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids." ; rdfs:label "Abnormal circulating dehydroepiandrosterone concentration" ; rdfs:subClassOf obo:HP_0030347 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28689 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500023 obo:IAO_0000115 "Absence of shoulder muscles." ; dc:date "2017-05-25T16:40:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absent shoulder muscle" ; a owl:Class ; rdfs:label "Shoulder muscle aplasia" ; rdfs:subClassOf obo:HP_0001464 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004476 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500024 obo:IAO_0000115 "Absence of the musculature of the pelvis." ; dc:date "2017-05-25T16:51:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Aplasia of the musculature of the pelvis" ; rdfs:subClassOf obo:HP_0001471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500026 obo:IAO_0000115 "Underdevelopment of the musculature of the pelvis." ; dc:date "2017-05-25T16:53:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hypoplasia of the musculature of the pelvis" ; rdfs:subClassOf obo:HP_0001471 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000645 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001325 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500027 obo:IAO_0000115 "Congenital absence of the colon" ; dc:date "2017-05-29T17:10:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Absence of the colon", "Aplasia of the colon" ; a owl:Class ; rdfs:label "Aplastic colon" ; rdfs:subClassOf obo:HP_0100811 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001483 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001155 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500028 obo:IAO_0000115 "Deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes." ; dc:date "2017-05-30T18:52:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "CWPs" ; a owl:Class ; rdfs:label "Cotton wool plaques" ; rdfs:subClassOf obo:HP_0100256 . obo:HP_0500030 obo:IAO_0000115 "Change in normal glycogen storage content." ; dc:date "2017-06-01T16:35:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal hepatic glycogen storage" ; rdfs:subClassOf obo:HP_0031137 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28087 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500031 obo:IAO_0000115 "An elevation in bone density in one or more carpal bones of the hand." ; dc:date "2017-06-01T16:54:00Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; a owl:Class ; rdfs:label "Sclerosis of the carpal bones" ; rdfs:subClassOf obo:HP_0004054 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:MPATH_184 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500032 obo:IAO_0000115 "Abnormality of the structure and branching of the dendrites of a neuron." ; dc:date "2017-06-07T17:35:08Z"^^xsd:dateTime ; dcterms:contributor ; dcterms:creator ; oboInOwl:hasExactSynonym "Aberrant neuronal branching", "Abnormal neuronal branching" ; a owl:Class ; rdfs:label "Abnormal neuron branching" ; rdfs:subClassOf obo:HP_0012757 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:GO_0044307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500033 obo:IAO_0000115 "Any abnormality in the proportion natural killer subsets relative to the total number of natural killer cells." ; dc:date "2018-01-08T19:18:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal natural killer subset distribution" ; rdfs:subClassOf obo:HP_0040089 . obo:HP_0500034 obo:IAO_0000115 "Blockage of the nasolacrimal sac." ; dc:date "2018-01-31T16:35:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasolacrimal sac obstruction" ; rdfs:subClassOf obo:HP_3000066 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000648 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001351 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500035 obo:IAO_0000115 "A mass of granulation tissue in response to chronic dacryocystitis as polypoid formations or they follow accidental injury, from probing and as a reaction to retained foreign bodies in the sac." ; dc:date "2018-01-31T16:48:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasolacrimal sac granuloma" ; rdfs:subClassOf obo:HP_0500034 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001847 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001351 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500036 obo:IAO_0000115 "Benign tumor of the nasolacrimal sac." ; dc:date "2018-01-31T16:58:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasolacrimal sac papilloma" ; rdfs:subClassOf obo:HP_0500035 . obo:HP_0500037 obo:IAO_0000115 "The malignant epithelial neoplasm with papillary growths in the nasolacrimal sac." ; dc:date "2018-01-31T17:14:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasolacrimal sac epithelial papillary carcinoma" ; rdfs:subClassOf obo:HP_3000066 . obo:HP_0500039 obo:IAO_0000115 "An abnormality of the conjuctiva and ocular surface caused by conjunctival inflammation and associated with scarring." ; dc:date "2018-02-02T14:47:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Cicatricial conjunctivitis", "Cicatrizating conjunctivitis", "Conjunctival cicatricial conjunctivitis" ; a owl:Class ; rdfs:label "Conjunctival cicatrization" ; rdfs:subClassOf obo:HP_0030947 . obo:HP_0500040 obo:IAO_0000115 "A benign tumor composed of adipose tissue and dense connective tissue usually located near the temporal fornix." ; dc:date "2018-02-02T15:28:59Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Conjunctival lipodermoid" ; a owl:Class ; rdfs:label "Dermolipoma of the conjunctiva" ; rdfs:subClassOf obo:HP_0500039 . obo:HP_0500041 obo:IAO_0000115 "A condition where one or both of the two principal meridians focus in the front of the retina when the eye is at rest." ; dc:date "2018-02-02T15:53:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Myopic astigmatism" ; rdfs:subClassOf obo:HP_0000483 . obo:HP_0500042 obo:IAO_0000115 "A term to describe when farsightedness is masked when the accommodative muscles are used to increase the focusing power of the eye." ; dc:date "2018-02-02T18:41:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Latent hyperopia" ; a owl:Class ; rdfs:label "Latent hypermetropia" ; rdfs:subClassOf obo:HP_0008499 . obo:HP_0500043 obo:IAO_0000115 "With the eyes in primary position, the sclera is visible above the superior corneal limbus." ; dc:date "2018-02-05T16:22:49Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Eyelid retraction" ; rdfs:subClassOf obo:HP_0000492 . obo:HP_0500044 obo:IAO_0000115 "An elevation of the eyelid above the normal level in the primary position." ; dc:date "2018-02-05T16:39:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Upper eyelid retraction" ; rdfs:subClassOf obo:HP_0500043 . obo:HP_0500045 obo:IAO_0000115 "A unilateral or bilateral eyelid retraction due to midbrain lesions." ; dc:date "2018-02-05T16:48:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Collier's sign" ; rdfs:subClassOf obo:HP_0500044 . obo:HP_0500046 obo:IAO_0000115 "Inflammation of the eyelid due to overactivity of the sebaceous gland." ; dc:date "2018-02-05T17:03:04Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "There is some suggestion that yeast bacterial strain called Malassezia furfur may cause seborrhoeic dermatitis. This yeast bacterial strain thrives in the oil of human skin especially in adults." ; rdfs:label "Seborrhoeic blepharitis" ; rdfs:subClassOf obo:HP_0025610 . obo:HP_0500047 obo:IAO_0000115 "A type of lymphoma that involves the nasolacrimal sac." ; dc:date "2018-02-12T18:31:38Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Nasolacrimal sac lymphoma" ; rdfs:subClassOf obo:HP_3000066 . obo:HP_0500048 obo:IAO_0000115 "A very common condition in which the extreme end of the nasolacrimal duct underneath the inferior turbinate fails to complete its canalization in the newborn period." ; dc:date "2018-02-19T15:38:47Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Delayed canalization of nasolacrimal duct" ; rdfs:subClassOf obo:HP_0000579 . obo:HP_0500049 obo:IAO_0000115 "An avascular or abnormally vascularized retina that occurs in premature infants and can lead to blindness." ; dc:date "2018-02-19T18:14:43Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Retinopathy of prematurity" ; rdfs:subClassOf obo:HP_0000488 . obo:HP_0500050 obo:IAO_0000115 "The retinal vessels stop and then a linear flat white line is present that usually runs the circumference of the vascular retina." ; dc:date "2018-02-19T18:27:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 1" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 1" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500051 obo:IAO_0000115 "The accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous." ; dc:date "2018-02-19T18:30:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 2" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 2" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500052 obo:IAO_0000115 "The neovascularization accumulates at the edge of the vascularized retina and extends into the vitreous (also called extra retinal fibrosis proliferation). In cases of Zone 2 and Zone 3, this may be sausage shaped. In more posterior Zone 1 disease, the stage 3 can appear as a direct extension of the normal retinal vessels but extending tangentially over the avascular retina." ; dc:date "2018-02-19T18:43:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 3" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 3" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500053 obo:IAO_0000115 "Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment." ; dc:date "2018-02-19T18:51:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 4" ; a owl:Class ; rdfs:comment "Stage 4 can occur after treatment (unlike stages 1-3) and may be accelerated by the absence of vascular endothelial growth factor posttreatment leading to an accelerated cicatricial phase." ; rdfs:label "Retinopathy of prematurity stage 4" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500054 obo:IAO_0000115 "A detachment that involves the peripheral retina that does not extend into the macula." ; dc:date "2018-02-19T18:56:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 4a" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 4a" ; rdfs:subClassOf obo:HP_0500053 . obo:HP_0500055 obo:IAO_0000115 "A detachment that involves the peripheral retina that involves the macula itself. The detachment usually starts in the temporal periphery although can also involve the nasal retina as well." ; dc:date "2018-02-19T18:56:48Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP 4b" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 4b" ; rdfs:subClassOf obo:HP_0500053 . obo:HP_0500056 obo:IAO_0000115 "Funnel detachment from the retina with generally traction in all four quadrants." ; dc:date "2018-02-19T19:11:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 5" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 5" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500057 obo:IAO_0000115 "An open funnel detachment of the retina with generally traction in all four quadrants." ; dc:date "2018-02-19T19:16:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 5a" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 5a" ; rdfs:subClassOf obo:HP_0500056 . obo:HP_0500058 obo:IAO_0000115 "A closed funnel detachment of the retina with generally traction in all four quadrants." ; dc:date "2018-02-19T19:16:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP stage 5b" ; a owl:Class ; rdfs:label "Retinopathy of prematurity stage 5b" ; rdfs:subClassOf obo:HP_0500056 . obo:HP_0500059 obo:IAO_0000115 "Retinopathy which extends from the center of the optic disc to twice the distance from the center of the optic disc to the center of the macula." ; dc:date "2018-02-19T19:24:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP zone 1" ; a owl:Class ; rdfs:label "Retinopathy of prematurity zone I" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500060 obo:IAO_0000115 "Retinopathy which extends centrifugally from the edge of zone I to the nasal ora serrata." ; dc:date "2018-02-19T19:52:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP zone II" ; a owl:Class ; rdfs:label "Retinopathy of prematurity zone II" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500061 obo:IAO_0000115 "Retinopathy which is a residual crescent of retina anterior to zone II." ; dc:date "2018-02-19T19:53:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP zone III" ; a owl:Class ; rdfs:label "Retinopathy of prematurity zone III" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500062 obo:IAO_0000115 "Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye." ; dc:date "2018-02-19T20:17:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP plus" ; a owl:Class ; rdfs:label "Retinopathy of prematurity plus" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500063 obo:IAO_0000115 "As vascular abnormalities of the posterior pole that are insufficient for the diagnosis of plus disease but that demonstrate more arterial tortuosity and more venous dilatation than normal." ; dc:date "2018-02-19T20:18:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP pre-plus" ; a owl:Class ; rdfs:comment "Over time, the vessel abnormalities of pre-plus may progress to frank plus disease as the vessels dilate and become more tortuous." ; rdfs:label "Retinopathy of prematurity pre-plus" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500064 obo:IAO_0000115 "A retinopathy with a 50% likelihood of progressing to retinal detachment. Threshold disease is considered to be present when stage 3 retinopathy of prematurity (ROP) is present in either zone I or zone II, with at least 5 continuous or 8 total clock hours of disease, and the presence of plus disease." ; dc:date "2018-02-19T20:26:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP threshold" ; a owl:Class ; rdfs:label "Retinopathy of prematurity threshold" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500065 obo:IAO_0000115 "High risk patients who were in Zone 1 (no Plus or stage 3) or Zone 2 with Plus or stage 3 but not both." ; dc:date "2018-02-19T20:26:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "ROP prethreshold" ; a owl:Class ; rdfs:label "Retinopathy of prematurity prethreshold" ; rdfs:subClassOf obo:HP_0500049 . obo:HP_0500066 obo:IAO_0000115 "The difference between total and manifest myopia." ; dc:date "2018-02-26T17:14:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Latent myopia" ; rdfs:subClassOf obo:HP_0000545 . obo:HP_0500069 obo:IAO_0000115 "A type of ectropion associated with orbicularis muscle weakness caused by cranial nerve VII palsy." ; dc:date "2018-02-26T17:37:32Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Paralytic ectropion" ; rdfs:subClassOf obo:HP_0000656 . obo:HP_0500070 obo:IAO_0000115 "A conjuctival lesion composed of adipose tissue and dense connective tissue. Such choristomas of dermal elements are normally found at the outer canthus, and have a gelatinous appearance. Classically, there is an indistinct posterior border (with the lesion frequently extending into the orbit) and a well-demarcated anterior border several millimetres posterior to the limbus." ; dc:date "2018-02-26T17:48:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Conjunctival dermolipoma" ; rdfs:subClassOf obo:HP_0000502 . obo:HP_0500072 obo:IAO_0000115 "Eccentric fixation in which the angle of eccentricity equals the objective angle of deviation." ; dc:date "2018-02-26T18:22:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Absolute eccentric fixation" ; rdfs:subClassOf obo:HP_0025549 . obo:HP_0500073 obo:IAO_0000115 "Any deviation from the normal ocular alignment." ; dc:date "2018-02-26T18:50:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal ocular alignment" ; rdfs:subClassOf obo:HP_0000496 . obo:HP_0500074 obo:IAO_0000115 "An incomitant tendency for an occluded eye to elevate and extort which resolves on uncovering." ; dc:date "2018-02-26T18:53:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Dissociated vertical deviation (DVD) occurs when the level of illumination received by either eye is reduced sufficiently and as a result eye deviates progressively upwards, but reverts to its original position when the level of illumination returns to normally acceptable levels. It may sometimes be so asymmetrical as to be virtually unilateral and is associated with heterotropia usually of early onset." ; rdfs:label "Dissociated vertical deviation" ; rdfs:subClassOf obo:HP_0500073 . obo:HP_0500075 obo:IAO_0000115 "A change in horizontal ocular alignment, unrelated to accommodation, that is brought about solely by a change in the balance of visual input from the two eyes." ; dc:date "2018-02-26T18:53:28Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Dissociated horizontal deviation" ; rdfs:subClassOf obo:HP_0500073 . obo:HP_0500076 obo:IAO_0000115 "A type of vertical tropia in which, when one eye is fixing, the other eye is deviated upwards." ; dc:date "2018-02-26T19:13:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alternating hypertropia" ; rdfs:subClassOf obo:HP_0025586 . obo:HP_0500077 obo:IAO_0000115 "A type of vertical phoria in which, in dissociation, the occluded eye deviates upwards." ; dc:date "2018-02-26T19:15:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alternating hyperphoria" ; rdfs:subClassOf obo:HP_0025585 . obo:HP_0500078 obo:IAO_0000115 "A type of vertical tropia in which, when one eye is fixing, the other eye is deviated downwards." ; dc:date "2018-02-26T19:22:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alternating hypotropia" ; rdfs:subClassOf obo:HP_0025584 . obo:HP_0500079 obo:IAO_0000115 "A type of vertical phoria in which, in dissociation, the occluded eye deviates downwards." ; dc:date "2018-02-26T19:24:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Alternating hypophoria" ; rdfs:subClassOf obo:HP_0031725 . obo:HP_0500081 obo:IAO_0000115 "The term pseudophakia refers to having an artificial lens implanted after the natural eye lens has been removed. During cataract surgery the natural cloudy lens is replaced by an pseudophakia intraocular lens (IOL)." ; dc:date "2018-02-26T20:00:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Pseudophakia" ; rdfs:subClassOf obo:HP_0000517 . obo:HP_0500086 obo:IAO_0000115 "Having a characteristic appearance of a slate gray area of pigmentation within the disc margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas." ; dc:date "2018-03-20T19:55:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Optic nerve grey crescent", "Temporal gray pigmentary crescent", "Temporal grey pigmentary crescent" ; a owl:Class ; rdfs:comment "This type of disc rim pigmentation can create the impression of neuroretinal rim thinning, and thus lead to the misdiagnosis of glaucoma or \"glaucoma suspect\" with attendant implications for overtreatment or unnecessary close monitoring of such patients." ; rdfs:label "Optic nerve gray crescent" ; rdfs:subClassOf obo:HP_0012511 . obo:HP_0500087 obo:IAO_0000115 "Thinning in the layers of the retina and retinal pigment epithelium around the optic nerve." ; dc:date "2018-03-20T20:01:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Peripapillary atrophy" ; rdfs:subClassOf obo:HP_0012512 . obo:HP_0500088 obo:IAO_0000115 "Loss of pigment in the fovea centralis." ; dc:date "2018-03-20T20:30:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Foveal depigmentation" ; rdfs:subClassOf obo:HP_0012643 . obo:HP_0500089 obo:IAO_0000115 "A benign tumor of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2." ; dc:date "2018-03-20T20:36:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Optic nerve sheath meningioma" ; rdfs:subClassOf obo:HP_0002858 . obo:HP_0500090 obo:IAO_0000115 "A capillary hemangioma surrounding the eyeball but within the orbit." ; dc:date "2018-03-27T14:45:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Peri-ocular capillary hemangioma" ; a owl:Class ; rdfs:label "Periocular capillary hemangioma" ; rdfs:subClassOf obo:HP_0005306 . obo:HP_0500091 obo:IAO_0000115 "A hamartoma of lymph vessels that usually presents in childhood. It tends to increase in size with head-down posture and with the Valsalva manoeuvre. Superficial lesions are visible as transilluminable cystic spaces of the lid or conjunctiva that may also contain blood. Deep lesions may cause gradual proptosis or present acutely with orbital pain and reduced vision due to haemorrhage." ; dc:date "2018-03-27T14:55:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Lymphangioma of the orbit" ; rdfs:subClassOf obo:HP_0030670, obo:HP_0100764 . obo:HP_0500092 obo:IAO_0000115 "A mesenchymal tumor that is considered to be the commonest primary orbital malignancy in children. Histologically, it may be differentiated into embryonal, alveolar, and pleomorphic types. It is usually intraconal or within the superior orbit." ; dc:date "2018-03-27T15:11:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Orbital rhabdomyosarcoma" ; rdfs:subClassOf obo:HP_0002859 . obo:HP_0500093 obo:IAO_0000115 "Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods." ; dc:date "2018-04-27T19:35:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Food allergy", "IgE-mediated food allergy", "Immunoglobulin E-mediated food allergy" ; a owl:Class ; rdfs:label "Food allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0500094 obo:IAO_0000115 "Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis." ; dc:date "2018-04-27T19:47:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Latex allergy" ; rdfs:subClassOf obo:HP_0012393 . obo:HP_0500095 obo:IAO_0000115 "Food-induced anaphylaxis is a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing food." ; dc:date "2018-04-27T19:55:30Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Food-induced anaphylaxis" ; rdfs:subClassOf obo:HP_0100845 . obo:HP_0500096 obo:IAO_0000115 "A form of anaphylaxis that is triggered by exposure to venom." ; dc:date "2018-04-27T20:09:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Venom-induced anaphylaxis" ; rdfs:subClassOf obo:HP_0100845 . obo:HP_0500097 obo:IAO_0000115 "Presence of xenobiotic in stool." ; dc:date "2018-05-21T13:42:31Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Stool xenobiotic" ; rdfs:subClassOf obo:HP_0031838 . obo:HP_0500098 obo:IAO_0000115 "Presence of a xenobiotic in meconium." ; dc:date "2018-05-21T13:43:07Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Meconium xenobiotic" ; rdfs:subClassOf obo:HP_0500097 . obo:HP_0500099 obo:IAO_0000115 "Presence of xenobiotic in hair." ; dc:date "2018-05-21T13:44:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Hair xenobiotic" ; rdfs:subClassOf obo:HP_0031838 . obo:HP_0500100 obo:IAO_0000115 "Presence of a xenobiotic in plasma and/or serum." ; dc:date "2018-05-21T13:45:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Plasma/serum xenobiotic" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0500101 obo:IAO_0000115 "Presence of a xenobiotic in gastric fluid." ; dc:date "2018-05-21T13:46:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Gastric fluid xenobiotic" ; rdfs:subClassOf obo:HP_0031838 . obo:HP_0500104 obo:IAO_0000115 "Abnormal decrease in diastolic blood pressure." ; dc:date "2018-06-22T13:58:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased diastolic BP", "Reduced diastolic blood pressure" ; a owl:Class ; rdfs:label "Decreased diastolic blood pressure" ; rdfs:subClassOf obo:HP_0002615 . obo:HP_0500105 obo:IAO_0000115 "Abnormal decrease in systolic blood pressure." ; dc:date "2018-06-22T14:02:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased systolic BP", "Reduced systolic blood pressure" ; a owl:Class ; rdfs:label "Decreased systolic blood pressure" ; rdfs:subClassOf obo:HP_0002615 . obo:HP_0500106 obo:IAO_0000115 "Elevated systolic blood pressure without an elevated blood pressure." ; dc:date "2018-06-22T14:04:14Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Isolated systolic hypertension or an elevated systolic blood pressure without an elevated diastolic blood pressure is a known risk factor for incident heart failure in older adults." ; rdfs:label "Isolated systolic hypertension" ; rdfs:subClassOf obo:HP_0004421 . obo:HP_0500107 obo:IAO_0000115 "A decrease in diastolic blood pressure (<60 mmHg) without a decrease in systolic blood pressure (> or = to 100 mmHg)." ; dc:date "2018-06-22T14:06:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Isolated diastolic hypotension is a risk factor for incident heart failure." ; rdfs:label "Isolated diastolic hypotension" ; rdfs:subClassOf obo:HP_0500104 . obo:HP_0500108 obo:IAO_0000115 "Detection of cocaine or its major metabolite, benzoylecgonine, in urine." ; dc:date "2018-06-25T15:07:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Cocaine is an illicit stimulant that has a high potential for abuse and addiction." ; rdfs:label "Positive urine cocaine test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500109 obo:IAO_0000115 "Detection of barbiturate metabolites such as Phenobarbital in urine." ; dc:date "2018-06-25T15:19:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Barbiturates are central nervous depressants. They can reduce heart rate, breathing, and blood pressure." ; rdfs:label "Positive urine barbiturate test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500110 obo:IAO_0000115 "Detection of delta-9-tetrahydrocannabinol (THC) or other cannabinoid metabolites in urine." ; dc:date "2018-06-25T15:40:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Positive urine marijuana test", "Postive urine pot test" ; a owl:Class ; rdfs:comment "Cannabis (marijuana, hashish) is the most widely used illegal drug in the world. The primary psychoactive component in cannabis is delta9-tetrahydrocannabinol (THC), which is rapidly metabolized to equipotent 11-hydroxy-THC (11-OH-THC) and non-psychoactive 11-nor-9-carboxy- delta9-tetrahydrocannabinol (THCCOOH)." ; rdfs:label "Positive urine cannabinoid test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500111 obo:IAO_0000115 "Detection of benzodiazepine metabolites, primarily nordiazepam, oxazepam, and temazepam, in urine." ; dc:date "2018-06-25T16:04:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive urine benzodiazepines test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500112 obo:IAO_0000115 "Detection of amphetamine or its metabolites in urine." ; dc:date "2018-06-25T16:49:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive urine amphetamine test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500113 obo:IAO_0000115 "Detection of opioids or opioid metabolites in urine." ; dc:date "2018-06-25T17:20:19Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Opiates are the natural or synthetic drugs that have a morphine-like pharmacological action. Medically, opiates are used primarily for relief of pain. Opiates include morphine and drugs structurally similar to morphine (eg, codeine, hydrocodone, hydromorphone, oxycodone)." ; rdfs:label "Positive urine opioid test" ; rdfs:subClassOf obo:HP_0031840 . obo:HP_0500114 obo:IAO_0000115 "Abnormal concentration of urobilinogen present in the stool." ; dc:date "2018-07-20T14:59:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal stool urobilinogen concentration" ; rdfs:subClassOf obo:HP_0031685 . obo:HP_0500115 obo:IAO_0000115 "An increased amount of urobilinogen present in the stool." ; dc:date "2018-07-20T15:00:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Urobilinogen is formed from the reduction of bilirubin. An increased amount of urobilinogen in the urine may be indicative of liver disease." ; rdfs:label "Increased stool urobilinogen concentration" ; rdfs:subClassOf obo:HP_0500114 . obo:HP_0500116 obo:IAO_0000115 "Detection of barbiturate metabolites such as Phenobarbital in blood." ; dc:date "2018-07-20T15:10:44Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Positive blood barbiturate test" ; rdfs:subClassOf obo:HP_0410172 . obo:HP_0500117 obo:IAO_0000115 "Abnormal concentration of urate in the cerebrospinal fluid (CSF)." ; dc:date "2018-07-20T15:35:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Urate is largely excluded from the brain under non-inflammatory conditions but increases in particular conditions such as Guillain-Barre Syndrome and bacterial meningitis." ; rdfs:label "Abnormal CSF urate concentration" ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_46819 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500132 obo:IAO_0000115 "A decreased amount of valine in the blood." ; dc:date "2018-10-01T14:47:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low blood valine concentration" ; a owl:Class ; rdfs:label "Hypovalinemia" ; rdfs:subClassOf obo:HP_0010914 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27266 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500133 obo:IAO_0000115 "An decreased concentration of tyrosine in the blood." ; dc:date "2018-10-01T15:01:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased tyrosine in blood", "Low blood tyrosine concentration" ; a owl:Class ; rdfs:label "Hypotyrosinemia" ; rdfs:subClassOf obo:HP_0010917 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500134 obo:IAO_0000115 "An increased amount of tryptophan in the blood." ; dc:date "2018-10-01T15:09:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood tryptophan concentration", "Increased tryptophan in blood" ; a owl:Class ; rdfs:label "Hypertryptophanemia" ; rdfs:subClassOf obo:HP_0004365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500135 obo:IAO_0000115 "A decreased amount of tryptophan in the blood." ; dc:date "2018-10-01T15:10:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased tryptophan in blood", "Low blood tryptophan concentration" ; a owl:Class ; rdfs:label "Hypotryptophanemia" ; rdfs:subClassOf obo:HP_0004365 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500136 obo:IAO_0000115 "A decreased amount of threonine in the blood." ; dc:date "2018-10-01T16:07:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating threonine levels", "Decreased threonine blood levels", "Low blood threonine concentration" ; a owl:Class ; rdfs:label "Hypothreoninemia" ; rdfs:subClassOf obo:HP_0010900 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500138 obo:IAO_0000115 "An increased amount of serine in the blood." ; dc:date "2018-10-01T16:54:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated circulating serine levels", "High blood serine levels", "Increased serine blood concentration" ; a owl:Class ; rdfs:label "Hyperserinemia" ; rdfs:subClassOf obo:HP_0012278 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17822 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500139 obo:IAO_0000115 "A decreased amount of proline in the blood." ; dc:date "2018-10-03T19:35:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood proline levels", "Low blood proline concentration" ; a owl:Class ; rdfs:label "Hypoprolinemia" ; rdfs:subClassOf obo:HP_0010907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26271 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500140 obo:IAO_0000115 "A decreased amount of hydroxyproline in the blood." ; dc:date "2018-10-03T19:43:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased hydroxyproline in the blood", "Low level of hydroxyproline in the blood" ; a owl:Class ; rdfs:label "Decreased circulating hydroxyproline concentration" ; rdfs:subClassOf obo:HP_0010907 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500141 obo:IAO_0000115 "A decreased amount of phenylalanine in the blood." ; dc:date "2018-10-03T19:58:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood phenylalanine", "Low blood phenylalanine" ; a owl:Class ; rdfs:label "Hypophenylalaninemia" ; rdfs:subClassOf obo:HP_0010893 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500142 obo:IAO_0000115 "A decreased amount of lysine in the blood." ; dc:date "2018-10-03T20:04:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood lysine", "Low blood lysine levels" ; a owl:Class ; rdfs:label "Hypolysinemia" ; rdfs:subClassOf obo:HP_0010908 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500143 obo:IAO_0000115 "Decreased amount of leucine in the blood." ; dc:date "2018-10-04T13:17:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood concentration of leucine", "Low blood leucine levels" ; a owl:Class ; rdfs:label "Hypoleucinemia" ; rdfs:subClassOf obo:HP_0004357 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500144 obo:IAO_0000115 "A decreased amount of isoleucine in the blood." ; dc:date "2018-10-04T13:22:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood isoleucine concentration", "Low blood isoleucine levels" ; a owl:Class ; rdfs:label "Hypoisoleucinemia" ; rdfs:subClassOf obo:HP_0010912 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500145 obo:IAO_0000115 "A decreased amount of histidine in the blood." ; dc:date "2018-10-04T13:28:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood histidine concentration", "Low blood histidine levels" ; a owl:Class ; rdfs:label "Hypohistidinemia" ; rdfs:subClassOf obo:HP_0010904 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500147 obo:IAO_0000115 "Decreased amount of glutamine in the blood." ; dc:date "2018-10-04T14:11:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood glutamine concentration", "Low blood glutamine level" ; a owl:Class ; rdfs:label "Hypoglutaminemia" ; rdfs:subClassOf obo:HP_0010903 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500148 obo:IAO_0000115 "Any deviation from the normal concentration of glutamate in the blood circulation." ; dc:date "2018-10-04T14:22:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of glutamate metabolism" ; a owl:Class ; rdfs:label "Abnormal circulating glutamate concentration" ; rdfs:subClassOf obo:HP_0010902 . obo:HP_0500149 obo:IAO_0000115 "Concentration of glutamate in the blood circulation above the upper limit of normal." ; dc:date "2018-10-04T14:29:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0410068" ; oboInOwl:hasExactSynonym "High blood glutamate levels", "Increased blood glutamate concentration", "Increased level of L-glutamic acid in blood" ; a owl:Class ; rdfs:comment "Under normal circumstances, plasma glutamate concentration is 5-100 microM/L, the whole blood concentration is 150-300 microM/L while in the brain's ECF it is only 0.3-2 microM/L." ; rdfs:label "Hyperglutamatemia" ; rdfs:subClassOf obo:HP_0500148 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500150 obo:IAO_0000115 "A decreased amount of glutamate in the blood." ; dc:date "2018-10-04T14:29:47Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood glutamate concentrations", "Low blood glutamate levels" ; a owl:Class ; rdfs:comment "Under normal circumstances, plasma glutamate concentration is 5-100 microM/L, the whole blood concentration is 150-300 microM/L while in the brain's ECF it is only 0.3-2 microM/L." ; rdfs:label "Hypoglutamatemia" ; rdfs:subClassOf obo:HP_0500148 . obo:HP_0500151 obo:IAO_0000115 "An increased amount of cystine in the blood." ; dc:date "2018-10-04T14:59:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood cystine levels", "Increased blood cystine concentraions" ; a owl:Class ; rdfs:label "Hypercystinemia" ; rdfs:subClassOf obo:HP_0010918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500152 obo:IAO_0000115 "A decreased amount of cystine in the blood." ; dc:date "2018-10-04T14:59:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood cystine concentration", "Low blood cystine levels" ; a owl:Class ; rdfs:label "Hypocystinemia" ; rdfs:subClassOf obo:HP_0010918 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500153 obo:IAO_0000115 "An increased amount of arginine levels in the blood." ; dc:date "2018-10-05T14:45:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood arginine levels", "Increased blood arginine concentration" ; a owl:Class ; rdfs:label "Hyperargininemia" ; rdfs:subClassOf obo:HP_0010909 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500154 obo:IAO_0000115 "A decreased amount of alanine in the blood." ; dc:date "2018-10-05T14:55:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood alanine concentration", "Low blood alanine levels" ; a owl:Class ; rdfs:label "Hypoalaninemia" ; rdfs:subClassOf obo:HP_0010916 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500155 obo:IAO_0000115 "Any deviation from the normal concentration of asparagine in the blood circulation." ; dc:date "2018-10-05T15:06:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of asparagine metabolism" ; a owl:Class ; rdfs:comment "Asparagine is a polar, aliphatic amino acid." ; rdfs:label "Abnormal circulating asparagine concentration" ; rdfs:subClassOf obo:HP_0010899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17196 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500156 obo:IAO_0000115 "An increased amount of asparagine in the blood." ; dc:date "2018-10-05T15:12:27Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood asaparagine levels", "Increased blood asparagine concentration" ; a owl:Class ; rdfs:label "Hyperasparaginemia" ; rdfs:subClassOf obo:HP_0500155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17196 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500157 obo:IAO_0000115 "A decreased amount of asparagine in the blood." ; dc:date "2018-10-05T15:12:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood asparagine concentration", "Low blood asparagine levels" ; a owl:Class ; rdfs:label "Hypoasparaginemia" ; rdfs:subClassOf obo:HP_0500155 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17196 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500158 obo:IAO_0000115 "Any deviation from the normal concentration of aspartate in the blood circulation." ; dc:date "2018-10-05T15:26:40Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating aspartate concentration" ; a owl:Class ; rdfs:comment "Aspartate is classified as an acidic amino acid." ; rdfs:label "Abnormal circulating aspartic acid concentration" ; rdfs:subClassOf obo:HP_0010899 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17053 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500159 obo:IAO_0000115 "An increased concentration of aspartic acid in the blood circulation." ; dc:date "2018-10-05T15:38:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood aspartic acid levels", "Increased blood aspartic acid", "Increased level of circulating aspartic acid" ; a owl:Class ; rdfs:label "Increased circulating aspartic acid concentration" ; rdfs:subClassOf obo:HP_0500158 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17053 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500160 obo:IAO_0000115 "Any deviation from the normal concentration of carnosine in the blood circulation." ; dc:date "2018-10-05T15:52:07Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormality of carnosine metabolism" ; a owl:Class ; rdfs:comment "Carnosine is a neuroprotective dipeptide consisting of beta-alanine and L-histidine." ; rdfs:label "Abnormal circulating carnosine concentration" ; rdfs:subClassOf obo:HP_0004354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500161 obo:IAO_0000115 "An increased amount of carnosine in the blood." ; dc:date "2018-10-05T16:07:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High blood carnosine levels", "Increased blood carnosine concenrtation" ; a owl:Class ; rdfs:label "Increased level of carnosine in blood" ; rdfs:subClassOf obo:HP_0500160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500162 obo:IAO_0000115 "A decreased amount of carnosine in bood." ; dc:date "2018-10-05T16:11:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood carnosine concentration", "Low blood carnosine levels" ; a owl:Class ; rdfs:label "Decreased level of carnosine in blood" ; rdfs:subClassOf obo:HP_0500160 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500163 obo:IAO_0000115 "An abnormal decrease in ornithine in the blood." ; dc:date "2018-10-12T13:25:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased blood ornithine concentrations", "Low blood ornithine levels" ; a owl:Class ; rdfs:label "Hypoornithinemia" ; rdfs:subClassOf obo:HP_0012025 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500164 obo:IAO_0000115 "An abnormality of carbon dioxide (CO2) in the arterial blood." ; dc:date "2018-10-17T15:09:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CO2 levels in blood", "Abnormal blood carbon dioxide level" ; a owl:Class ; rdfs:label "Abnormal blood carbon dioxide level" ; rdfs:subClassOf obo:HP_0012415 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500165 obo:IAO_0000115 "An abnormality of the partial pressure of oxygen in the arterial blood." ; dc:date "2018-10-17T15:14:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal O2 blood concentration", "Abnormal blood O2 level", "Abnormal blood oxygen levels" ; a owl:Class ; rdfs:label "Abnormal blood oxygen level" ; rdfs:subClassOf obo:HP_0012415 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500166 obo:IAO_0000115 "An abnormal concentration of gastrin in the blood." ; dc:date "2018-11-05T18:46:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal circulating gastrin level" ; a owl:Class ; rdfs:label "Abnormal circulating gastrin concentration" ; rdfs:subClassOf obo:HP_0003117 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500167 obo:IAO_0000115 "An elevated amount of gastrin in the blood." ; dc:date "2018-11-05T18:51:20Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated gastrin in the blood", "Increased blood gastrin" ; a owl:Class ; rdfs:label "Hypergastrinemia" ; rdfs:subClassOf obo:HP_0500166 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000007856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500170 obo:IAO_0000115 "An abnormal amount of acylcarnitine in the urine." ; dc:date "2018-11-05T19:19:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Combined, the total daily bile and urine production of acylcarnitine is <200 micromol." ; rdfs:label "Abnormal concentration of acylcarnitine in the urine" ; rdfs:subClassOf obo:HP_0033354 . obo:HP_0500173 obo:IAO_0000115 "A loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure." ; dc:date "2018-11-20T13:57:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Reflex anoxic seizure", "Reflex anoxic seizures" ; a owl:Class ; rdfs:label "Reflex asystolic syncope"@en ; rdfs:subClassOf obo:HP_0001279 . obo:HP_0500180 dc:date "2019-02-22T17:26:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal circulating amino sulfonic acid concentration"@en ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0500181 obo:IAO_0000115 "An increased amount of taurine in the blood." ; dc:date "2019-02-22T17:28:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated serum taurine levels", "Increased circulating taurine levels in the blood" ; a owl:Class ; rdfs:label "Hypertaurinemia"@en ; rdfs:subClassOf obo:HP_0500180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500182 obo:IAO_0000115 "A decreased amount of taurine in the blood." ; dc:date "2019-02-22T17:29:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased circulating taurine levels", "Lower blood levels of taurine", "Reduced taurine levels in the blood" ; a owl:Class ; rdfs:label "Hypotaurinemia"@en ; rdfs:subClassOf obo:HP_0500180 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500183 obo:IAO_0000115 "Any deviation from the normal concentration of a carboxylic acid in the cerebrospinal fluid." ; dc:date "2019-02-25T15:15:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal CSF carboxylic acid concentration"@en ; rdfs:subClassOf obo:HP_0025454 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33575 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500184 obo:IAO_0000115 "Any deviation from the normal concentration of amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T15:20:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:0032364" ; oboInOwl:hasExactSynonym "Abnormal CSF amino acid level", "Abnormal amino acid levels in cerebrospinal fluid", "Abnormal cerebrospinal fluid amino acid level" ; a owl:Class ; rdfs:label "Abnormal CSF amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500183 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33709 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500185 obo:IAO_0000115 "Any deviation from the normal concentration of branched-chain amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T15:24:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal branched-chain amino acid levels in cerbrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF branched chain amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500186 obo:IAO_0000115 "Any deviation from the normal concentration of valine in the cerebrospinal fluid." ; dc:date "2019-02-25T15:28:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal valine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF valine concentration"@en ; rdfs:subClassOf obo:HP_0500185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27266 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500187 obo:IAO_0000115 "Any increased amount from normal of valine in the cerebrospinal fluid." ; dc:date "2019-02-25T15:37:57Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High valine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF valine concentration"@en ; rdfs:subClassOf obo:HP_0500186 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33575 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500188 obo:IAO_0000115 "Any decreased amount from normal of valine in the cerebrospinal fluid." ; dc:date "2019-02-25T15:40:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low valine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF valine concentration"@en ; rdfs:subClassOf obo:HP_0500186 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33575 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500189 obo:IAO_0000115 "Any deviation from the normal concentration of leucine in the cerebrospinal fluid." ; dc:date "2019-02-25T15:52:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal leucine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF leucine concentration"@en ; rdfs:subClassOf obo:HP_0500185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500190 obo:IAO_0000115 "Abnormally decreased levels of leucine in the cerebrospinal fluid." ; dc:date "2019-02-25T15:52:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low leucine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF leucine concentration"@en ; rdfs:subClassOf obo:HP_0500189 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500191 obo:IAO_0000115 "Abnormally increased levels of leucine in cerebrospinal fluid." ; dc:date "2019-02-25T15:53:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High leucine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF leucine concentration"@en ; rdfs:subClassOf obo:HP_0500189 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25017 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500192 obo:IAO_0000115 "Any deviation from the normal concentration of isoleucine in the cerebrospinal fluid." ; dc:date "2019-02-25T16:24:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal isoleucine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF isoleucine concentration"@en ; rdfs:subClassOf obo:HP_0500185 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500193 obo:IAO_0000115 "Abnormally increased levels of isoleucine in cerebrospinal fluid." ; dc:date "2019-02-25T16:25:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High levels of isoleucine in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF isoleucine concentration"@en ; rdfs:subClassOf obo:HP_0500192 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500194 obo:IAO_0000115 "Abnormally decreased levels of isoleucine in cerebrospinal fluid." ; dc:date "2019-02-25T16:25:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low levels of isoleucine in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF isoleucine concentration"@en ; rdfs:subClassOf obo:HP_0500192 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24898 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500195 obo:IAO_0000115 "Any deviation from the normal concentration of glutamine-family amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T16:41:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal glutamine family amino acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF glutamine family amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_24318 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500196 obo:IAO_0000115 "Any deviation from the normal concentration of glutamine amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T16:42:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal glutamine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF glutamine concentration"@en ; rdfs:subClassOf obo:HP_0500195 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500197 obo:IAO_0000115 "Abnormally increased levels of glutamine in cerebrospinal fluid." ; dc:date "2019-02-25T16:43:02Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High glutamine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF glutamine concentration"@en ; rdfs:subClassOf obo:HP_0500196 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500198 obo:IAO_0000115 "Abnormally decreased levels of glutamine in cerebrospinal fluid." ; dc:date "2019-02-25T16:43:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low glutamine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF glutamine concentration"@en ; rdfs:subClassOf obo:HP_0500196 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500199 obo:IAO_0000115 "Any deviation from the normal concentration of glutamic acid in the cerebrospinal fluid." ; dc:date "2019-02-25T16:56:56Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal glutamic acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF glutamate concentration"@en ; rdfs:subClassOf obo:HP_0500195 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500200 obo:IAO_0000115 "Abnormally increased levels of glutamic acid in cerebrospinal fluid." ; dc:date "2019-02-25T16:57:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High glutamic acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF glutamate concentration"@en ; rdfs:subClassOf obo:HP_0500199 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500201 obo:IAO_0000115 "Abnormally decreased levels of glutamic acid in cerebrospinal fluid." ; dc:date "2019-02-25T16:57:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low glutamic acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF glutamate concentration"@en ; rdfs:subClassOf obo:HP_0500199 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18237 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500202 obo:IAO_0000115 "Any deviation from the normal concentration of arginine in the cerebrospinal fluid." ; dc:date "2019-02-25T17:12:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal arginine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF arginine concentration"@en ; rdfs:subClassOf obo:HP_0500195 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500203 obo:IAO_0000115 "Abnormally increased levels of arginine in cerebrospinal fluid." ; dc:date "2019-02-25T17:12:38Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High arginine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF arginine concentration"@en ; rdfs:subClassOf obo:HP_0500202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500204 obo:IAO_0000115 "Abnormally decreased levels of arginine in cerebrospinal fluid." ; dc:date "2019-02-25T17:12:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low arginine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF arginine concentration"@en ; rdfs:subClassOf obo:HP_0500202 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_29016 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500205 obo:IAO_0000115 "Any deviation from the normal concentration of aspartate-family amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T18:30:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal aspartate-family amino acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF aspartate family amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_22658 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500206 obo:IAO_0000115 "Any deviation from the normal concentration of lysine in the cerebrospinal fluid." ; dc:date "2019-02-25T18:31:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal lysine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF lysine concentration"@en ; rdfs:subClassOf obo:HP_0500205 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500207 obo:IAO_0000115 "Abnormally decreased levels of lysine in cerebrospinal fluid." ; dc:date "2019-02-25T18:31:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low lysine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF lysine concentration"@en ; rdfs:subClassOf obo:HP_0500206 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500208 obo:IAO_0000115 "Abnormally increased levels of lysine in cerebrospinal fluid." ; dc:date "2019-02-25T18:32:16Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High lysine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF lysine concentration"@en ; rdfs:subClassOf obo:HP_0500206 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_25094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500209 obo:IAO_0000115 "Any deviation from the normal concentration of methionine in the cerebrospinal fluid." ; dc:date "2019-02-25T18:58:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal methionine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF methionine concentration"@en ; rdfs:subClassOf obo:HP_0500205 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16811 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500210 obo:IAO_0000115 "Concentration of methionine in the cerebrospinal fluid above the upper limit of normal." ; dc:date "2019-02-25T18:58:44Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High methionine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF methionine concentration"@en ; rdfs:subClassOf obo:HP_0500209 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16811 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500211 obo:IAO_0000115 "Any deviation from the normal concentration of threonine in the cerebrospinal fluid." ; dc:date "2019-02-25T19:08:53Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal threonine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF threonine concentration"@en ; rdfs:subClassOf obo:HP_0500205 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500212 obo:IAO_0000115 "Abnormally increased levels of threonine in cerebrospinal fluid." ; dc:date "2019-02-25T19:09:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High threonine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF threonine concentration"@en ; rdfs:subClassOf obo:HP_0500211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500213 obo:IAO_0000115 "Abnormally decreased levels of threonine in cerebrospinal fluid." ; dc:date "2019-02-25T19:10:14Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low threonine levels in the cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF threonine concentration"@en ; rdfs:subClassOf obo:HP_0500211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500214 obo:IAO_0000115 "Any deviation from the normal concentration of aromatic amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T19:28:05Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal aromatic amino acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF aromatic amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_33856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500215 obo:IAO_0000115 "Any deviation from the normal concentration of phenylalanine in the cerebrospinal fluid." ; dc:date "2019-02-25T19:28:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal phenylalanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF phenylalanine concentration"@en ; rdfs:subClassOf obo:HP_0500214 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500216 obo:IAO_0000115 "Any deviation from the normal concentration of aspartic acid in the cerebrospinal fluid." ; dc:date "2019-02-25T19:31:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CSF aspartic acid concentration", "Abnormal aspartic acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF aspartate concentration"@en ; rdfs:subClassOf obo:HP_0500205 . obo:HP_0500217 obo:IAO_0000115 "Abnormally increased levels of aspartic acid in cerebrospinal fluid." ; dc:date "2019-02-25T19:32:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High aspartic acid levels in cerebrospinal fluid", "Increased CSF aspartic acid concentration" ; a owl:Class ; rdfs:label "Increased CSF aspartate concentration"@en ; rdfs:subClassOf obo:HP_0500216 . obo:HP_0500218 obo:IAO_0000115 "Any deviation from the normal concentration of tryptophan in the cerebrospinal fluid." ; dc:date "2019-02-25T19:44:06Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal tryptophan levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF tryptophan concentration"@en ; rdfs:subClassOf obo:HP_0500214 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500219 obo:IAO_0000115 "Any deviation from the normal concentration of tyrosine in the cerebrospinal fluid." ; dc:date "2019-02-25T19:48:03Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal tyrosine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF tyrosine concentration"@en ; rdfs:subClassOf obo:HP_0500214 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500220 obo:IAO_0000115 "Abnormally increased levels of tyrosine in cerebrospinal fluid." ; dc:date "2019-02-25T19:53:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High tyrosine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF tyrosine concentration"@en ; rdfs:subClassOf obo:HP_0500219 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500221 obo:IAO_0000115 "Abnormally decreased levels of tyrosine in cerebrospinal fluid." ; dc:date "2019-02-25T19:53:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low tyrosine levels in the cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF tyrosine concentration"@en ; rdfs:subClassOf obo:HP_0500219 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500222 obo:IAO_0000115 "Abnormally increased levels of tryptophan in cerebrospinal fluid." ; dc:date "2019-02-25T20:07:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High tryptophan levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF tryptophan concentration"@en ; rdfs:subClassOf obo:HP_0500218 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27897 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500223 obo:IAO_0000115 "Abnormally increased levels of phenylalanine in cerebrospinal fluid." ; dc:date "2019-02-25T20:13:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High phenylalanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF phenylalanine concentration"@en ; rdfs:subClassOf obo:HP_0500215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500224 obo:IAO_0000115 "Abnormally decreased levels of phenylalanine in cerebrospinal fluid." ; dc:date "2019-02-25T20:13:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low phenylalanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF phenylalanine concentration"@en ; rdfs:subClassOf obo:HP_0500215 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500225 obo:IAO_0000115 "Any deviation from the normal concentration of serine-family amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T20:27:34Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serine-family amino acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF serine family amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26650 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500226 obo:IAO_0000115 "Any deviation from the normal concentration of serine in the cerebrospinal fluid." ; dc:date "2019-02-25T20:30:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal serine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF serine concentration"@en ; rdfs:subClassOf obo:HP_0500225 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17822 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500227 obo:IAO_0000115 "Abnormally increased levels of serine in cerebrospinal fluid." ; dc:date "2019-02-25T20:32:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High serine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF serine concentration"@en ; rdfs:subClassOf obo:HP_0500226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17822 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500228 obo:IAO_0000115 "Abnormally decreased levels of serine in cerebrospinal fluid." ; dc:date "2019-02-25T20:32:46Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low serine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF serine concentration"@en ; rdfs:subClassOf obo:HP_0500226 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_17822 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500229 obo:IAO_0000115 "Any deviation from the normal concentration of glycine in the cerebrospinal fluid." ; dc:date "2019-02-25T20:40:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal glycine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF glycine concentration"@en ; rdfs:subClassOf obo:HP_0500225 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15428 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500230 obo:IAO_0000115 "Abnormally increased levels of glycine in cerebrospinal fluid." ; dc:date "2019-02-25T20:40:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High glycine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF glycine concentration"@en ; rdfs:subClassOf obo:HP_0500229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15428 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500231 obo:IAO_0000115 "Any deviation from the normal concentration of pyruvate-family amino acids in the cerebrospinal fluid." ; dc:date "2019-02-25T20:53:35Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal pyruvate-family amino acid levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF pyruvate family amino acid concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_26463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500232 obo:IAO_0000115 "Any deviation from the normal concentration of alanine in the cerebrospinal fluid." ; dc:date "2019-02-25T20:53:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal alanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF alanine concentration"@en ; rdfs:subClassOf obo:HP_0500231 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500233 obo:IAO_0000115 "Abnormally increased levels of alanine in cerebrospinal fluid." ; dc:date "2019-02-25T20:55:23Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High alanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF alanine concentration"@en ; rdfs:subClassOf obo:HP_0500232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500234 obo:IAO_0000115 "Abnormally decreased levels of alanine in cerebrospinal fluid." ; dc:date "2019-02-25T20:55:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low alanine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF alanine concentration"@en ; rdfs:subClassOf obo:HP_0500232 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16449 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500235 obo:IAO_0000115 "Any deviation from the normal concentration of histidine in the cerebrospinal fluid." ; dc:date "2019-02-25T21:07:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal histidine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF histidine concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500236 obo:IAO_0000115 "Abnormally increased levels of histidine in cerebrospinal fluid." ; dc:date "2019-02-25T21:08:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High histidine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF histidine concentration"@en ; rdfs:subClassOf obo:HP_0500235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500237 obo:IAO_0000115 "Abnormally decreased levels of histidine in cerebrospinal fluid." ; dc:date "2019-02-25T21:08:33Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Low histidine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Decreased CSF histidine concentration"@en ; rdfs:subClassOf obo:HP_0500235 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_27570 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500238 obo:IAO_0000115 "Any deviation from the normal concentration of albumin in the cerebrospinal fluid." ; dc:date "2019-02-26T15:00:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal albumin levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF albumin concentration"@en ; rdfs:subClassOf obo:HP_0025456 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500239 dc:date "2019-02-26T15:00:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High albumin levels in cerebrospinal fluid" ; a owl:Class ; rdfs:comment "Abnormally increased levels of albumin in cerebrospinal fluid." ; rdfs:label "Increased CSF albumin concentration"@en ; rdfs:subClassOf obo:HP_0500238 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500240 obo:IAO_0000115 "Any deviation from the normal concentration of carnosine in the cerebrospinal fluid." ; dc:date "2019-02-26T15:25:43Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal carnosine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF carnosine concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500241 obo:IAO_0000115 "Any deviation from the normal concentration of homocarnosine in the cerebrospinal fluid." ; dc:date "2019-02-26T15:26:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal homocarnosine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF homocarnosine concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500242 obo:IAO_0000115 "Abnormally increased levels of homocarnosine in cerebrospinal fluid." ; dc:date "2019-02-26T15:26:24Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High homocarnosine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF homocarnosine concentration"@en ; rdfs:subClassOf obo:HP_0500241 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_28050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500243 obo:IAO_0000115 "Any deviation from the normal concentration of ornithine in the cerebrospinal fluid." ; dc:date "2019-02-26T15:36:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal ornithine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF ornithine concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500244 obo:IAO_0000115 "Abnormally increased levels of ornithine in cerebrospinal fluid." ; dc:date "2019-02-26T15:36:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High ornithine levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF ornithine concentration"@en ; rdfs:subClassOf obo:HP_0500243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500245 obo:IAO_0000115 "Any deviation from the normal concentration of citrulline in the cerebrospinal fluid." ; dc:date "2019-02-26T15:48:42Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal citrulline levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF citrulline concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500246 obo:IAO_0000115 "Abnormally increased levels of citrulline in cerebrospinal fluid." ; dc:date "2019-02-26T15:49:01Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High citrulline levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF citrulline concentration"@en ; rdfs:subClassOf obo:HP_0500245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_18211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500247 obo:IAO_0000115 "Any deviation from the normal concentration of alpha-aminobutyrate in the cerebrospinal fluid." ; dc:date "2019-02-26T15:59:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal alpha-aminobutyrate levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Abnormal CSF alpha-aminobutyrate concentration"@en ; rdfs:subClassOf obo:HP_0500184 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_86508 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500248 obo:IAO_0000115 "Concentration of alpha-aminobutyrate in the cerebrospinal fluid above the upper limit of normal." ; dc:date "2019-02-26T15:59:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High alpha-aminobutyrate levels in cerebrospinal fluid" ; a owl:Class ; rdfs:label "Increased CSF alpha-aminobutyrate concentration"@en ; rdfs:subClassOf obo:HP_0500247 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_86508 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001359 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500249 obo:IAO_0000115 "Any deviation from the normal concentration of ethanolamine in circulation." ; dc:date "2019-02-26T16:08:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal ethanolamine levels in the blood" ; a owl:Class ; rdfs:label "Abnormal circulating ethanolamine concentration"@en ; rdfs:subClassOf obo:HP_0033405 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500250 obo:IAO_0000115 "Abnormally increased levels of ethanolamine in circulation." ; dc:date "2019-02-26T16:09:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High ethanolamine levels in the blood" ; a owl:Class ; rdfs:label "Increased circulating ethanolamine concentration"@en ; rdfs:subClassOf obo:HP_0500249 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_23981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500251 obo:IAO_0000115 "Abnormal concentration of sebacic acid in the urine." ; dc:date "2019-03-08T19:58:13Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal urine decanedioic acid concentration" ; a owl:Class ; rdfs:label "Abnormal urine sebacic acid concentration"@en ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_41865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500252 obo:IAO_0000115 "Elevated concentration of sebacic acid in the urine." ; dc:date "2019-03-08T20:03:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urine decanedioic acid concentration" ; a owl:Class ; rdfs:label "Increased urine sebacic acid concentration"@en ; rdfs:subClassOf obo:HP_0500251 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_41865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500253 obo:IAO_0000115 "Elevated concentration of gamma-aminobutyric acid in the urine." ; dc:date "2019-03-08T20:23:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased urinary excretion of gamma-aminobutyric acid (GABA)" ; a owl:Class ; rdfs:label "Increased level of gamma-aminobutyric acid in urine"@en ; rdfs:subClassOf obo:HP_0033098 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16865 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500254 obo:IAO_0000115 "Abnormal concentration of hexanoylglycine in the urine." ; dc:date "2019-03-08T20:56:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal urinary N-hexanoylglycine levels" ; a owl:Class ; rdfs:label "Abnormal urine hexanoylglycine concentration"@en ; rdfs:subClassOf obo:HP_0033354 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_64390 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500255 obo:IAO_0000115 "Elevated concentration of hexanoylglycine in the urine." ; dc:date "2019-03-08T21:01:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated urinary N-hexanoylglycine concentration" ; a owl:Class ; rdfs:label "Increased level of hexanoylglycine in urine"@en ; rdfs:subClassOf obo:HP_0500254 . obo:HP_0500256 obo:IAO_0000115 "Abnormal concentration of isobutyrylglycine in the urine." ; dc:date "2019-03-08T21:14:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal urinary isobutyrylglycine levels" ; a owl:Class ; rdfs:label "Abnormal urine isobutyrylglycine concentration"@en ; rdfs:subClassOf obo:HP_0012073 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500257 obo:IAO_0000115 "Elevated concentration of isobutyrylglycine in the urine." ; dc:date "2019-03-08T21:15:36Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "High urinary isobutyrylglycine levels" ; a owl:Class ; rdfs:label "Increased urine isobutyrylglycine concentration"@en ; rdfs:subClassOf obo:HP_0500256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_70979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001088 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500258 obo:IAO_0000115 "Abnormal amount of carbon dioxide in umbilical cord blood" ; dc:date "2019-04-23T17:10:09Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal CO2 level in cord blood", "Abnormal umbilical cord blood levels of carbon dioxide" ; a owl:Class ; rdfs:label "Abnormal carbon dioxide level in cord blood"@en ; rdfs:subClassOf obo:HP_0410211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_16526 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500259 obo:IAO_0000115 "An abnormal level of blood oxygen in the cord blood." ; dc:date "2019-04-23T17:11:51Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal O2 level in cord blood", "Abnormal cord blood oxygen levels", "Abnormal oxygen amount in umbilical cord blood" ; a owl:Class ; rdfs:label "Abnormal oxygen level in cord blood"@en ; rdfs:subClassOf obo:HP_0410211 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CHEBI_15379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012168 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500260 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a head trauma." ; dc:date "2019-04-30T14:17:10Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Head trauma triggered symptoms" ; a owl:Class ; rdfs:label "Triggered by head trauma"@en ; rdfs:subClassOf obo:HP_0031135 . obo:HP_0500261 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to anesthetics." ; dc:date "2019-04-30T14:21:26Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anaesthetics trigger episodes", "Anaesthetics triggered symptoms", "Anesthetics trigger episodes", "Anesthetics triggered symptoms", "Triggered by anaesthetics" ; a owl:Class ; rdfs:comment "Symptoms that are provoked by anesthetics adminstration, including halothane, sevoflurane, desflurane, enflurane, isoflurane, propofol, or etomidate." ; rdfs:label "Triggered by anesthetics"@en ; rdfs:subClassOf obo:HP_4000101 . obo:HP_0500262 obo:IAO_0000115 "The most dramatic and severe form of hair loss characterized by an absence of hair follicles." ; dc:date "2019-08-21T15:12:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Atrichia"@en ; rdfs:subClassOf obo:HP_0011362 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001997 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:CL_0002559 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500263 obo:IAO_0000115 "Abnormal proportion of helper T cells relative to the total number of T cells." ; dc:date "2020-05-15T19:15:28Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of circulating T-helper cells" ; a owl:Class ; rdfs:label "Abnormal helper T cell proportion"@en ; rdfs:subClassOf obo:HP_0025540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500264 obo:IAO_0000115 "Increased proportion of helper T cells relative to the total number of T cells." ; dc:date "2020-05-15T19:19:04Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated helper T cell proportion", "Increased proportion T-helper cells" ; a owl:Class ; rdfs:label "Increased helper T cell proportion"@en ; rdfs:subClassOf obo:HP_0500263 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500265 obo:IAO_0000115 "An increased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; dc:date "2020-05-15T19:32:37Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Increased proportion of effector memory CD8-positive, alpha-beta T cells, terminally differentiated" ; a owl:Class ; rdfs:label "Increased proportion of CD8-positive, alpha-beta TEMRA T cells"@en ; rdfs:subClassOf obo:HP_0020177, obo:HP_0410392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500266 obo:IAO_0000115 "An decreased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." ; dc:date "2020-05-15T19:36:00Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion effector memory CD8-positive, alpha-beta T cells, terminally differentiated" ; a owl:Class ; rdfs:label "Decreased proportion of CD8-positive, alpha-beta TEMRA T cells"@en ; rdfs:subClassOf obo:HP_0020177, obo:HP_0410385 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0001062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500267 obo:IAO_0000115 "An abnormal proportion of circulating CD4-positive helper T cells relative to total T cell count." ; dc:date "2020-05-15T20:12:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal proportion of CD4-positive helper T cells"@en ; rdfs:subClassOf obo:HP_0025540, obo:HP_0031392 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000492 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500269 obo:IAO_0000115 "Abnormal proportion of gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T14:55:58Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of gamma-delta T-lymphocytes", "Abnormal proportion of gammadelta T cells", "Abnormal proprotion of gamma-delta T lymphocytes" ; a owl:Class ; rdfs:label "Abnormal proportion of gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0500270 obo:IAO_0000115 "Increased proportion of gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T15:10:25Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of gamma-delta T cells", "Increased proportion of gamma-delta T lymphocytes", "Increased proportion of gamma-delta T-cells", "Increased proportion of gamma-delta T-lymphocytes", "Increased proportion of gammadelta T cells" ; a owl:Class ; rdfs:label "Increased proportion of gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0500269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500271 obo:IAO_0000115 "Decreased proportion of gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T15:10:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of gamma-delta T lymphocytes", "Decreased proportion of gamma-delta T-cells", "Decreased proportion of gamma-delta T-lymphocytes", "Decreased proportion of gammadelta T cells", "Reduced proportion of gamma-delta T cells" ; a owl:Class ; rdfs:label "Decreased proportion of gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0500269 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000798 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500272 obo:IAO_0000115 "Abnormal proportion of immature gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T15:39:19Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Abnormal proportion of immature gamma-delta T lymphocytes", "Abnormal proportion of immature gamma-delta T-cells", "Abnormal proportion of immature gamma-delta T-lymphocytes" ; a owl:Class ; rdfs:label "Abnormal proportion of immature gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0025540 . obo:HP_0500273 obo:IAO_0000115 "Increased proportion of immature gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T15:39:31Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Elevated proportion of immature gamma-delta T cells", "Increased proportion of immature gamma-delat T lymphocytes", "Increased proportion of immature gamma-delta T-cells", "Increased proportion of immature gamma-delta T-lymphocytes" ; a owl:Class ; rdfs:label "Increased proportion of immature gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0500270, obo:HP_0500272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040043 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0500274 obo:IAO_0000115 "Decreased proportion of immature gamma-delta T cells relative to the total number of T cells." ; dc:date "2020-05-19T15:39:41Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Decreased proportion of immature gamma-delta T lymphocytes", "Decreased proportion of immature gamma-delta T-cells", "Decreased proportion of immature gamma-delta T-lymphocytes", "Reduced proportion of immature gamma-delta T cells" ; a owl:Class ; rdfs:label "Decreased proportion of immature gamma-delta T cells"@en ; rdfs:subClassOf obo:HP_0500271, obo:HP_0500272 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0040042 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:CL_0000799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:CL_0000084 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_0550003 obo:IAO_0000115 "Symmetrical thickening, tightening and induration of the skin of the fingers and the skin proximal to the metacarpophalangeal or metatarsophalangeal joints. These changes can involve the entire limb, face, neck and trunk." ; dc:date "2017-08-02T22:02:40Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Proximal scleroderma" ; rdfs:subClassOf obo:HP_0100324 . obo:HP_0550004 obo:IAO_0000115 "Slightly raised wart 2-5 mm in diameter often associated with viral infections, commonly persistent in immunodeficient individuals." ; dc:date "2017-08-03T19:50:21Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Flat wart" ; a owl:Class ; rdfs:label "Verruca plana" ; rdfs:subClassOf obo:HP_0200043 . obo:HP_0550005 obo:IAO_0000115 "It is a bilateral reticular pattern of linear or lineonodular densities that are most pronounced in basilar portions of the lungs on standard chest x-ray. It is the third minor criterion for scleroderma diagnosis." ; dc:date "2017-08-03T19:57:54Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Lung disease with systemic sclerosis", "Scleroderma lung disease", "Scleroderma of lung" ; a owl:Class ; rdfs:label "Bilateral basilar pulmonary fibrosis" ; rdfs:subClassOf obo:HP_0002206 . obo:HP_3000001 obo:IAO_0100001 "HP:0001627" ; oboInOwl:id "HP:3000001" ; a owl:Class ; rdfs:label "obsolete Abnormal heart morphology" ; owl:deprecated true . obo:HP_3000002 obo:IAO_0000115 "Any structural anomaly of an inner ear epithelium." ; dcterms:creator ; oboInOwl:creation_date "2014-07-15T23:41:38Z" ; oboInOwl:hasDbXref "UMLS:C4073211" ; oboInOwl:id "HP:3000002" ; a owl:Class ; rdfs:label "Abnormal inner ear epithelium morphology" ; rdfs:subClassOf obo:HP_0011390 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006937 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000003 obo:IAO_0000115 "An abnormality of a mandibular ramus." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:38:57Z" ; oboInOwl:hasDbXref "UMLS:C4073212" ; oboInOwl:hasExactSynonym "Abnormality of mandibular ramus" ; oboInOwl:id "HP:3000003" ; a owl:Class ; rdfs:label "Abnormal mandibular ramus morphology" ; rdfs:subClassOf obo:HP_0000163, obo:HP_0000277 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0000401 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000004 obo:IAO_0000115 "An abnormality of a frontalis muscle belly." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:42:54Z" ; oboInOwl:hasDbXref "UMLS:C4073213" ; oboInOwl:id "HP:3000004" ; a owl:Class ; rdfs:label "Abnormality of frontalis muscle belly" ; rdfs:subClassOf obo:HP_0000290, obo:HP_0040172 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010952 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000005 obo:IAO_0000115 "An abnormality of a masseter muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:43:00Z" ; oboInOwl:hasDbXref "UMLS:C4073214" ; oboInOwl:id "HP:3000005" ; a owl:Class ; rdfs:label "Abnormality of masseter muscle" ; rdfs:subClassOf obo:HP_0410011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000006 obo:IAO_0000115 "An abnormality of a medial pterygoid muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:43:06Z" ; oboInOwl:hasDbXref "UMLS:C4073215" ; oboInOwl:id "HP:3000006" ; a owl:Class ; rdfs:label "Abnormality of medial pterygoid muscle" ; rdfs:subClassOf obo:HP_0410011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006718 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000007 obo:IAO_0000115 "An abnormality of a mentalis muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:43:12Z" ; oboInOwl:hasDbXref "UMLS:C4073216" ; oboInOwl:id "HP:3000007" ; a owl:Class ; rdfs:label "Abnormality of mentalis muscle" ; rdfs:subClassOf obo:HP_0000306, obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008596 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000008 obo:IAO_0000115 "An abnormality of a mylohyoid muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:43:17Z" ; oboInOwl:hasDbXref "UMLS:C4073217" ; oboInOwl:id "HP:3000008" ; a owl:Class ; rdfs:label "Abnormality of mylohyoid muscle" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0410012, obo:HP_0410013 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001564 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000009 obo:IAO_0000115 "An abnormality of a nasalis muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:55:52Z" ; oboInOwl:hasDbXref "UMLS:C4073218" ; oboInOwl:id "HP:3000009" ; a owl:Class ; rdfs:label "Abnormality of nasalis muscle" ; rdfs:subClassOf obo:HP_0000366, obo:HP_0430018 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010953 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000010 obo:IAO_0000115 "An abnormality of an orbicularis oris muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:55:58Z" ; oboInOwl:hasDbXref "UMLS:C4073219" ; oboInOwl:id "HP:3000010" ; a owl:Class ; rdfs:label "Abnormality of orbicularis oris muscle" ; rdfs:subClassOf obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010933 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000011 obo:IAO_0000115 "An abnormality of a palatoglossus muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:56:03Z" ; oboInOwl:hasDbXref "UMLS:C4073220" ; oboInOwl:id "HP:3000011" ; a owl:Class ; rdfs:label "Abnormality of palatoglossus muscle" ; rdfs:subClassOf obo:HP_0040174, obo:HP_0430014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001574 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000012 obo:IAO_0000115 "An abnormality of a palatopharyngeus muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:56:09Z" ; oboInOwl:hasDbXref "UMLS:C4073221" ; oboInOwl:id "HP:3000012" ; a owl:Class ; rdfs:label "Abnormality of palatopharyngeus muscle" ; rdfs:subClassOf obo:HP_0430014, obo:HP_0430015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000013 obo:IAO_0000115 "An abnormality of the platysma muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:56:14Z" ; oboInOwl:hasDbXref "UMLS:C4073222" ; oboInOwl:hasExactSynonym "Abnormality of platysma", "Abnormality of the platysma muscle" ; oboInOwl:id "HP:3000013" ; a owl:Class ; rdfs:label "Abnormal platysma muscle morphology" ; rdfs:subClassOf obo:HP_0000301, obo:HP_0001574, obo:HP_0011006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0005467 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000014 obo:IAO_0000115 "An abnormality of a procerus." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:58:45Z" ; oboInOwl:hasDbXref "UMLS:C4073223" ; oboInOwl:id "HP:3000014" ; a owl:Class ; rdfs:label "Abnormality of procerus muscle" ; rdfs:subClassOf obo:HP_0000366, obo:HP_0430018 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008588 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000015 obo:IAO_0000115 "An abnormality of a risorius muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:58:51Z" ; oboInOwl:hasDbXref "UMLS:C4073224" ; oboInOwl:id "HP:3000015" ; a owl:Class ; rdfs:label "Abnormality of risorius muscle" ; rdfs:subClassOf obo:HP_0004426, obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008598 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000016 obo:IAO_0000115 "An abnormality of the styloglossus muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:58:56Z" ; oboInOwl:hasDbXref "UMLS:C4073225" ; oboInOwl:id "HP:3000016" ; a owl:Class ; rdfs:label "Abnormality of styloglossus muscle" ; rdfs:subClassOf obo:HP_0040174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000017 obo:IAO_0000115 "An abnormality of a temporalis muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:59:01Z" ; oboInOwl:hasDbXref "UMLS:C4073226" ; oboInOwl:id "HP:3000017" ; a owl:Class ; rdfs:label "Abnormality of temporalis muscle" ; rdfs:subClassOf obo:HP_0410011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001598 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000018 obo:IAO_0000115 "An abnormality of a zygomaticus major muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-02-26T03:59:07Z" ; oboInOwl:hasDbXref "UMLS:C4073227" ; oboInOwl:id "HP:3000018" ; a owl:Class ; rdfs:label "Abnormality of zygomaticus major muscle" ; rdfs:subClassOf obo:HP_0004426, obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008593 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000019 obo:IAO_0000115 "An abnormality of a buccal mucosa." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:13:17Z" ; oboInOwl:hasDbXref "UMLS:C4073228" ; oboInOwl:hasExactSynonym "Abnormality of buccal mucosa", "Abnormality of cheek mucosa", "Abnormality of inside lining of cheek" ; oboInOwl:id "HP:3000019" ; a owl:Class ; rdfs:label "Abnormal buccal mucosa morphology" ; rdfs:subClassOf obo:HP_0004426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003729 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006956 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000020 obo:IAO_0000115 "An abnormality of a zygomaticus minor muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:15:45Z" ; oboInOwl:hasDbXref "UMLS:C4073229" ; oboInOwl:id "HP:3000020" ; a owl:Class ; rdfs:label "Abnormality of zygomaticus minor muscle" ; rdfs:subClassOf obo:HP_0004426, obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008594 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000021 obo:IAO_0000115 "An abnormality of a buccal fat pad." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:15:49Z" ; oboInOwl:hasDbXref "UMLS:C4073230" ; oboInOwl:hasExactSynonym "Abnormality of buccal fat pad" ; oboInOwl:id "HP:3000021" ; a owl:Class ; rdfs:label "Abnormal buccal fat pad morphology" ; rdfs:subClassOf obo:HP_0004426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012167 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000022 obo:IAO_0000115 "An abnormality of a cartilage of external ear." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:15:54Z" ; oboInOwl:hasDbXref "UMLS:C4073231" ; oboInOwl:id "HP:3000022" ; a owl:Class ; rdfs:label "Abnormality of cartilage of external ear" ; rdfs:subClassOf obo:HP_0000377, obo:HP_0002763 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001867 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000023 obo:IAO_0000115 "An abnormality of the angular artery, the terminal branch of the facial artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:15:58Z" ; oboInOwl:hasDbXref "UMLS:C4073232" ; oboInOwl:id "HP:3000023" ; a owl:Class ; rdfs:label "Abnormality of angular artery" ; rdfs:subClassOf obo:HP_3000024 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000024 obo:IAO_0000115 "Any structural abnormality of a facial artery, one of the branches of the external carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:16:03Z" ; oboInOwl:hasDbXref "UMLS:C4073233" ; oboInOwl:hasExactSynonym "Abnormality of facial artery" ; oboInOwl:id "HP:3000024" ; a owl:Class ; rdfs:label "Abnormal facial artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001612 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000025 obo:IAO_0000115 "An abnormality of a ciliary ganglion." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:16:07Z" ; oboInOwl:hasDbXref "UMLS:C4073234" ; oboInOwl:id "HP:3000025" ; a owl:Class ; rdfs:label "Abnormality of ciliary ganglion" ; rdfs:subClassOf obo:HP_0410016 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002058 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000026 oboInOwl:consider "HP:0430021" ; oboInOwl:id "HP:3000026" ; a owl:Class ; rdfs:label "obsolete Abnormality of common carotid artery plus branches" ; owl:deprecated true . obo:HP_3000027 obo:IAO_0000115 "An abnormality of a buccinator muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:16:16Z" ; oboInOwl:hasDbXref "UMLS:C4073236" ; oboInOwl:id "HP:3000027" ; a owl:Class ; rdfs:label "Abnormality of buccinator muscle" ; rdfs:subClassOf obo:HP_0004426 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000028 obo:IAO_0000115 "An abnormality of a depressor anguli oris muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:16:20Z" ; oboInOwl:hasDbXref "UMLS:C4073237" ; oboInOwl:id "HP:3000028" ; a owl:Class ; rdfs:label "Abnormality of depressor anguli oris muscle" ; rdfs:subClassOf obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000029 obo:IAO_0000115 "An abnormality of a depressor labii inferioris." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:16:25Z" ; oboInOwl:hasDbXref "UMLS:C4073238" ; oboInOwl:hasExactSynonym "Abnormality of depressor labii inferioris muscle" ; oboInOwl:id "HP:3000029" ; a owl:Class ; rdfs:label "Abnormality of depressor labii inferioris" ; rdfs:subClassOf obo:HP_0000306, obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001581 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000030 obo:IAO_0000115 "An abnormality of an orbit of skull." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:27:07Z" ; oboInOwl:hasDbXref "UMLS:C4073239" ; oboInOwl:hasExactSynonym "Abnormality of bones of the orbit of the skull", "Abnormality of bony orbit of skull", "Abnormality of the bony eye socket", "Abnormality of the orbital bones of skull" ; oboInOwl:id "HP:3000030" ; a owl:Class ; rdfs:label "Abnormal morphology of bony orbit of skull" ; rdfs:subClassOf obo:HP_0000315, obo:HP_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001697 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000031 obo:IAO_0000115 "An abnormality of an anterior ethmoidal artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:27:12Z" ; oboInOwl:hasDbXref "UMLS:C4073287" ; oboInOwl:id "HP:3000031" ; a owl:Class ; rdfs:label "Abnormality of anterior ethmoidal artery" ; rdfs:subClassOf obo:HP_0410006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0012318 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000032 obo:IAO_0000115 "An abnormality of a central retinal artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:27:17Z" ; oboInOwl:hasDbXref "UMLS:C4073240" ; oboInOwl:id "HP:3000032" ; a owl:Class ; rdfs:comment "The central retinal artery is a small branch of the ophthalmic artery that extends forward a short distance before entering the meningeal sheath of the nerve about 10 to 12 mm behind the globe of the eye." ; rdfs:label "Abnormality of central retinal artery" ; rdfs:subClassOf obo:HP_0410006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001620 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000033 obo:IAO_0000115 "Any abnormality of nasopharyngeal adenoids." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:27:21Z" ; oboInOwl:hasDbXref "UMLS:C4073241" ; oboInOwl:hasExactSynonym "Abnormality of adenoids", "Abnormality of nasopharyngeal adenoids", "Abnormality of nasopharyngeal tonsil", "Abnormality of pharyngeal tonsil" ; oboInOwl:id "HP:3000033" ; a owl:Class ; rdfs:comment "The adenoid, a mass of lymphatic tissue situated posterior to the nasal cavity, in the roof of the nasopharynx, where the nose blends into the throat." ; rdfs:label "Abnormal nasopharyngeal adenoid morphology" ; rdfs:subClassOf obo:HP_0001739, obo:HP_0100765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001732 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000034 obo:IAO_0000115 "An abnormality of a cartilage of nasal septum." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:27:26Z" ; oboInOwl:hasDbXref "UMLS:C4073242" ; oboInOwl:hasExactSynonym "Abnormality of cartilage of nasal septum", "Abnormality of cartilage of septum of nose", "Anomaly of cartilage of nasal septum" ; oboInOwl:hasNarrowSynonym "Deformity of cartilage of nasal septum", "Malformation of cartilage of nasal septum" ; oboInOwl:id "HP:3000034" ; a owl:Class ; rdfs:label "Abnormality nasal septum cartilage morphology" ; rdfs:subClassOf obo:HP_0000419, obo:HP_0002763, obo:HP_0010937 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003407 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000035 obo:IAO_0000115 "Abnormality of the plexus of the ventral rami of the first four cervical spinal nerves which are located from C1 to C4 cervical segment in the neck." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:35:58Z" ; oboInOwl:hasDbXref "UMLS:C4073243" ; oboInOwl:id "HP:3000035" ; a owl:Class ; rdfs:label "Abnormality of cervical plexus" ; rdfs:subClassOf obo:HP_0410010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003725 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000036 obo:IAO_0000115 "An abnormality of a blood vessel of the head, including branches of the arterial and venous systems of the head." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:02Z" ; oboInOwl:hasDbXref "UMLS:C4073244" ; oboInOwl:hasExactSynonym "Abnormality of blood vessel of head", "Abnormality of head blood vessel", "Abnormality of vasculature of head" ; oboInOwl:id "HP:3000036" ; a owl:Class ; rdfs:label "Abnormal head blood vessel morphology" ; rdfs:subClassOf obo:HP_0000234, obo:HP_0025015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003496 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000037 obo:IAO_0000115 "An abnormality of a blood vessel of the neck, including branches of the arterial and venous systems of the neck." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:06Z" ; oboInOwl:hasDbXref "UMLS:C4073245" ; oboInOwl:hasExactSynonym "Abnormality of blood vessel of neck", "Abnormality of neck blood vessel", "Abnormality of the cervical blood vessels", "Abnormality of the cervical vasculature", "Abnormality of the vasculature of the neck" ; oboInOwl:id "HP:3000037" ; a owl:Class ; rdfs:label "Abnormal neck blood vessel morphology" ; rdfs:subClassOf obo:HP_0025015, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003502 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000038 obo:IAO_0000115 "Any structural abnormality of a cricoid cartilage, that is, of the ring-shaped cartilage of the larynx." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:11Z" ; oboInOwl:hasDbXref "UMLS:C4073246" ; oboInOwl:hasExactSynonym "Abnormality of cricoid cartilage" ; oboInOwl:id "HP:3000038" ; a owl:Class ; rdfs:label "Abnormal cricoid cartilage morphology" ; rdfs:subClassOf obo:HP_0002763, obo:HP_0025423 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0002375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000039 obo:IAO_0000115 "An abnormality of a dorsal nasal artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:15Z" ; oboInOwl:hasDbXref "UMLS:C4073247" ; oboInOwl:id "HP:3000039" ; a owl:Class ; rdfs:label "Abnormality of dorsal nasal artery" ; rdfs:subClassOf obo:HP_0410006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001623 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000040 obo:IAO_0000115 "An abnormality of an ethmoid sinus." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:19Z" ; oboInOwl:hasDbXref "UMLS:C4073248" ; oboInOwl:hasExactSynonym "Abnormality of ethmoidal air cells" ; oboInOwl:id "HP:3000040" ; a owl:Class ; rdfs:label "Abnormality of ethmoid sinus" ; rdfs:subClassOf obo:HP_0000245 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0002453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000041 obo:IAO_0000115 "An abnormality of an external carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T00:36:24Z" ; oboInOwl:hasBroadSynonym "Abnormality of carotid artery", "Disorder of carotid artery" ; oboInOwl:hasDbXref "UMLS:C4073249" ; oboInOwl:id "HP:3000041" ; a owl:Class ; rdfs:label "Abnormality of external carotid artery" ; rdfs:subClassOf obo:HP_0005344 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001070 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000042 obo:IAO_0000115 "Any structural abnormality of a jugular vein." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:04:39Z" ; oboInOwl:hasDbXref "UMLS:C4073250" ; oboInOwl:hasExactSynonym "Abnormality of jugular vein" ; oboInOwl:id "HP:3000042" ; a owl:Class ; rdfs:label "Abnormal jugular vein morphology" ; rdfs:subClassOf obo:HP_0002624, obo:HP_3000037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000043 obo:IAO_0000115 "An abnormality of a facial vein." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:04:44Z" ; oboInOwl:hasDbXref "UMLS:C4073251" ; oboInOwl:hasExactSynonym "Abnormal vein of face", "Abnormality of facial vein" ; oboInOwl:id "HP:3000043" ; a owl:Class ; rdfs:label "Abnormal facial vein morphology" ; rdfs:subClassOf obo:HP_0002624, obo:HP_3000036, obo:HP_3000037 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001653 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000044 obo:IAO_0000115 "An abnormality of a frontal process of the maxilla bone." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:04:49Z" ; oboInOwl:hasDbXref "UMLS:C4073252" ; oboInOwl:id "HP:3000044" ; a owl:Class ; rdfs:label "Abnormality of frontal process of maxilla" ; rdfs:subClassOf obo:HP_0000326 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0013767 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000045 obo:IAO_0000115 "An abnormality of a genioglossus muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:04:53Z" ; oboInOwl:hasDbXref "UMLS:C4073253" ; oboInOwl:id "HP:3000045" ; a owl:Class ; rdfs:label "Abnormality of genioglossus muscle" ; rdfs:subClassOf obo:HP_0040174 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001571 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000046 obo:IAO_0000115 "An abnormality of a geniohyoid muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:04:58Z" ; oboInOwl:hasDbXref "UMLS:C4073254" ; oboInOwl:id "HP:3000046" ; a owl:Class ; rdfs:label "Abnormal geniohyoid muscle morphology" ; rdfs:subClassOf obo:HP_0011006 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001565 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000047 obo:IAO_0000115 "Any structural anomaly of the glossopharyngeal nerve, the ninth paired cranial nerve (CN IX)." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:08:41Z" ; oboInOwl:hasDbXref "UMLS:C4073255" ; oboInOwl:hasExactSynonym "Abnormality of glossopharyngeal nerve" ; oboInOwl:id "HP:3000047" ; a owl:Class ; rdfs:comment "The glossopharyngeal nerve originates in the medulla oblongata. It Innervates the oropharynx, carotid body and sinus, as well as the posterior third of the tongue (where it mediates taste sensation), the middle ear cavity and the Eustachian tube. Additionally, it innervates the stylopharyngeus muscle of the pharynx." ; rdfs:label "Abnormal glossopharyngeal nerve morphology" ; rdfs:subClassOf obo:HP_0001291, obo:HP_0045010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001649 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000048 obo:IAO_0000115 "Any structural anomaly of a great auricular nerve." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:08:45Z" ; oboInOwl:hasDbXref "UMLS:C4073256" ; oboInOwl:id "HP:3000048" ; a owl:Class ; rdfs:comment "The great auricular nerve originates from the cervical plexus and ascends to the posterior inferior region of the parotid gland, where it divides into several small branches. The nerve supplies sensation for an extensive area of the face including the skin over the parotid gland and the mastoid process and the surface of the external ear. The great auricular nerve winds around the posterior aspect of the sternocleidomastoid muscle. After perforating the deep fascia, it ascends upon the sternocleidomastoid muscle beneath the platysma to the parotid gland, where it divides into an anterior and a posterior branch. The anterior branch provides sensory innervation to the skin overlying the parotid gland and communicates with the facial nerve in the substance of the gland. The posterior branch innervates the skin over the mastoid and the posterior surface of the auricle except at its upper part." ; rdfs:label "Abnormal great auricular nerve morphology" ; rdfs:subClassOf obo:HP_0045010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008833 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000049 obo:IAO_0000115 "An abnormality of a greater palatine artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:08:50Z" ; oboInOwl:hasDbXref "UMLS:C4073257" ; oboInOwl:hasExactSynonym "Abnormality of greater palatine artery" ; oboInOwl:id "HP:3000049" ; a owl:Class ; rdfs:comment "The greater palatine artery is a terminal branch of the maxillary artery that supplies blood to the hard palate and nasal septum." ; rdfs:label "Abnormal greater palatine artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006664 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000050 obo:IAO_0000115 "An abnormality of an odontoid tissue." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:08:54Z" ; oboInOwl:hasDbXref "UMLS:C4073258" ; oboInOwl:hasExactSynonym "Abnormality of hard tissues of teeth", "Abnormality of odontoid tissue", "Abnormality of tooth hard tissue" ; oboInOwl:id "HP:3000050" ; a owl:Class ; rdfs:label "Abnormal odontoid tissue morphology" ; rdfs:subClassOf obo:HP_0000924, obo:HP_0003549 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0010365 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000051 obo:IAO_0000115 "An abnormality of a hyoglossus muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:08:58Z" ; oboInOwl:hasDbXref "UMLS:C4073259" ; oboInOwl:hasExactSynonym "Abnormality of hyoglossus muscle" ; oboInOwl:id "HP:3000051" ; a owl:Class ; rdfs:label "Abnormal hyoglossus muscle morphology" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0030809 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001572 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000052 obo:IAO_0000115 "Any structural abnormality of the hyoid bone (hyoid), a small U-shaped (horseshoe-shaped) solitary bone, situated in the midline of the neck anteriorly at the base of the mandible and posteriorly at the fourth cervical vertebra." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:09:03Z" ; oboInOwl:hasDbXref "UMLS:C4073260" ; oboInOwl:hasExactSynonym "Abnormality of hyoid bone" ; oboInOwl:id "HP:3000052" ; a owl:Class ; rdfs:label "Abnormal hyoid bone morphology" ; rdfs:subClassOf obo:HP_0011842 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001685 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000053 obo:IAO_0000115 "A structural anomaly of the hypopharyx, which is the most inferior portion of the pharynx. The hypopharynx continues from the oropharynx at the pharyngoepiglottic fold superiorly and extends inferiorly to the level of the inferior aspect of the cricoid cartilage, which marks the beginning of the cervical esophagus." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:09:07Z" ; oboInOwl:hasDbXref "UMLS:C4073261" ; oboInOwl:hasExactSynonym "Abnormality of hypopharynx", "Abnormality of lower pharynx" ; oboInOwl:id "HP:3000053" ; a owl:Class ; rdfs:label "Abnormal hypopharynx morphology" ; rdfs:subClassOf obo:HP_0033151 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001051 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000054 obo:IAO_0000115 "An abnormality of an inferior alveolar artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:09:11Z" ; oboInOwl:hasDbXref "UMLS:C4073262" ; oboInOwl:id "HP:3000054" ; a owl:Class ; rdfs:label "Abnormal inferior alveolar artery morphology" ; rdfs:subClassOf obo:HP_0031816, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0014693 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000055 obo:IAO_0000115 "An abnormality of an inferior alveolar nerve." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T01:10:08Z" ; oboInOwl:hasDbXref "UMLS:C4073263" ; oboInOwl:id "HP:3000055" ; a owl:Class ; rdfs:comment "The inferior alveolar nerve is a branch of the mandibular nerve, which is itself the third branch of the trigeminal nerve." ; rdfs:label "Abnormality of inferior alveolar nerve" ; rdfs:subClassOf obo:HP_0001291, obo:HP_0045010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0018405 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000056 obo:IAO_0000115 "An abnormality of an artery of lower lip." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:34Z" ; oboInOwl:hasDbXref "UMLS:C4073264" ; oboInOwl:hasExactSynonym "Abnormality of the inferior labial artery" ; oboInOwl:id "HP:3000056" ; a owl:Class ; rdfs:label "Abnormality of artery of lower lip" ; rdfs:subClassOf obo:HP_3000024 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0003471 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000057 obo:IAO_0000115 "An abnormality of an inferior oblique extraocular muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:39Z" ; oboInOwl:hasDbXref "UMLS:C4073265" ; oboInOwl:hasExactSynonym "Abnormality of the inferior oblique muscle" ; oboInOwl:id "HP:3000057" ; a owl:Class ; rdfs:label "Abnormality of inferior oblique extraocular muscle" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006320 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000058 obo:IAO_0000115 "An abnormality of an inferior rectus extraocular muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:44Z" ; oboInOwl:hasDbXref "UMLS:C4073266" ; oboInOwl:id "HP:3000058" ; a owl:Class ; rdfs:label "Abnormality of inferior rectus extraocular muscle" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000059 obo:IAO_0000115 "An abnormality of an inferior thyroid vein." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:48Z" ; oboInOwl:hasDbXref "UMLS:C4073267" ; oboInOwl:hasExactSynonym "Abnormality of inferior thyroid vein" ; oboInOwl:id "HP:3000059" ; a owl:Class ; rdfs:label "Abnormal inferior thyroid vein morphology" ; rdfs:subClassOf obo:HP_0002624 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0007156 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000060 obo:IAO_0000115 "An abnormality of an infraorbital artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:53Z" ; oboInOwl:hasDbXref "UMLS:C4073268" ; oboInOwl:hasExactSynonym "Abnormality of infraorbital artery" ; oboInOwl:id "HP:3000060" ; a owl:Class ; rdfs:label "Abnormal infraorbital artery morphology" ; rdfs:subClassOf obo:HP_0025015 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0004646 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000061 obo:IAO_0000115 "A structural abnormality of an infra-orbital nerve. The infraorbital nerve arises from the maxillary branch of the trigeminal nerve and normally traverses the orbital floor in the infraorbital canal." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:18:57Z" ; oboInOwl:hasDbXref "UMLS:C4073269" ; oboInOwl:hasExactSynonym "Abnormality of the infraorbital nerve" ; oboInOwl:id "HP:3000061" ; a owl:Class ; rdfs:label "Abnormality of infra-orbital nerve" ; rdfs:subClassOf obo:HP_0010824 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0018408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000062 obo:IAO_0000115 "An abnormality of an internal carotid artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:19:02Z" ; oboInOwl:hasDbXref "UMLS:C1860488" ; oboInOwl:hasExactSynonym "Abnormality of internal carotid artery" ; oboInOwl:id "HP:3000062" ; a owl:Class ; rdfs:label "Abnormal internal carotid artery morphology" ; rdfs:subClassOf obo:HP_0005344, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001532 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000063 obo:IAO_0000115 "An abnormality of an internal jugular vein." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:19:06Z" ; oboInOwl:hasDbXref "UMLS:C4073270" ; oboInOwl:id "HP:3000063" ; a owl:Class ; rdfs:label "Abnormality of internal jugular vein" ; rdfs:subClassOf obo:HP_3000042 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001586 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000064 obo:IAO_0000115 "An abnormality of an intrinsic muscle of tongue." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:19:10Z" ; oboInOwl:hasDbXref "UMLS:C4073271" ; oboInOwl:hasExactSynonym "Abnormality of intrinsic lingual muscle" ; oboInOwl:id "HP:3000064" ; a owl:Class ; rdfs:label "Abnormality of intrinsic muscle of tongue" ; rdfs:subClassOf obo:HP_0040173 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001576 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000065 obo:IAO_0000115 "An abnormality of a lacrimal artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:25Z" ; oboInOwl:hasDbXref "UMLS:C4073272" ; oboInOwl:hasExactSynonym "Abnormality of lacrimal artery" ; oboInOwl:id "HP:3000065" ; a owl:Class ; rdfs:label "Abnormal lacrimal artery morphology" ; rdfs:subClassOf obo:HP_0011004, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001622 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000066 obo:IAO_0000115 "An abnormality of a lacrimal sac." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:31Z" ; oboInOwl:hasDbXref "UMLS:C4073273" ; oboInOwl:hasExactSynonym "Abnormality of lacrimal sac" ; oboInOwl:id "HP:3000066" ; a owl:Class ; rdfs:label "Abnormal lacrimal sac morphology" ; rdfs:subClassOf obo:HP_0000614 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001351 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000067 obo:IAO_0000115 "Any structural abnormality of a lateral crico-arytenoid muscle, which extends from the lateral cricoid cartilage to the muscular process of the arytenoid cartilage, and can adduct the vocal cords, which closes the rima glottidis and thereby protects the airway." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:35Z" ; oboInOwl:hasDbXref "UMLS:C4073274" ; oboInOwl:hasExactSynonym "Abnormal anterior cricoarytenoid muscle morphology", "Abnormality of lateral crico-arytenoid", "Abnormality of lateral cricoarytenoid muscle" ; oboInOwl:id "HP:3000067" ; a owl:Class ; rdfs:label "Abnormal lateral cricoarytenoid muscle morphology" ; rdfs:subClassOf obo:HP_0011805, obo:HP_0025423, obo:HP_0025668 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0008573 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000068 obo:IAO_0000115 "An abnormality of a lateral pterygoid muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:40Z" ; oboInOwl:hasDbXref "UMLS:C4073275" ; oboInOwl:id "HP:3000068" ; a owl:Class ; rdfs:label "Abnormality of lateral pterygoid muscle" ; rdfs:subClassOf obo:HP_0410011 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0006719 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000069 obo:IAO_0000115 "An abnormality of a lateral rectus extra-ocular muscle." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:44Z" ; oboInOwl:hasDbXref "UMLS:C4073276" ; oboInOwl:id "HP:3000069" ; a owl:Class ; rdfs:label "Abnormality of lateral rectus extra-ocular muscle" ; rdfs:subClassOf obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001603 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000070 obo:IAO_0000115 "An abnormality of a levator anguli oris." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:48Z" ; oboInOwl:hasDbXref "UMLS:C4073277" ; oboInOwl:id "HP:3000070" ; a owl:Class ; rdfs:label "Abnormality of levator anguli oris" ; rdfs:subClassOf obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008595 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000071 obo:IAO_0000115 "An abnormality of a levator labii superioris." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:52Z" ; oboInOwl:hasDbXref "UMLS:C4073278" ; oboInOwl:id "HP:3000071" ; a owl:Class ; rdfs:label "Abnormality of levator labii superioris" ; rdfs:subClassOf obo:HP_0430019 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0001580 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000072 obo:IAO_0000115 "An abnormality of a levator palpebrae superioris." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:38:57Z" ; oboInOwl:hasDbXref "UMLS:C4073279" ; oboInOwl:id "HP:3000072" ; a owl:Class ; rdfs:label "Abnormal levator palpebrae superioris morphology" ; rdfs:subClassOf obo:HP_0000492, obo:HP_0008049 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001604 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000073 obo:IAO_0000115 "An abnormality of a levator veli palatini." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:01Z" ; oboInOwl:hasDbXref "UMLS:C4073280" ; oboInOwl:id "HP:3000073" ; a owl:Class ; rdfs:label "Abnormality of levator veli palatini muscle" ; rdfs:subClassOf obo:HP_0430014 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0008585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000074 obo:IAO_0000115 "Any structural abnormality of a lingual artery." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:06Z" ; oboInOwl:hasDbXref "UMLS:C4073281" ; oboInOwl:hasExactSynonym "Abnormality of lingual artery" ; oboInOwl:id "HP:3000074" ; a owl:Class ; rdfs:label "Abnormal lingual artery morphology" ; rdfs:subClassOf obo:HP_0011004, obo:HP_0030809, obo:HP_3000036 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0001610 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000075 obo:IAO_0000115 "Any structural anomaly of a lingual nerve." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:10Z" ; oboInOwl:hasDbXref "UMLS:C4073282" ; oboInOwl:hasExactSynonym "Abnormality of lingual nerve" ; oboInOwl:id "HP:3000075" ; a owl:Class ; rdfs:comment "The lingual nerve (LN) is one of the two terminal branches of the posterior division of the mandibular nerve. It supplies the general sensation to the mucosa of the anterior two-thirds of the tongue, the sublingual mucosa, the mandibular lingual gingiva and the floor of the mouth.The chorda tympani nerve, a branch of the facial nerve joins this nerve carrying taste fibers from the anterior two third of the tongue and parasympathetic fibers to the submandibular ganglion." ; rdfs:label "Abnormal lingual nerve morphology" ; rdfs:subClassOf obo:HP_0045010 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000076 obo:IAO_0000115 "An abnormality of a lingual tonsil." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:15Z" ; oboInOwl:hasDbXref "UMLS:C4073283" ; oboInOwl:id "HP:3000076" ; a owl:Class ; rdfs:label "Abnormality of lingual tonsil" ; rdfs:subClassOf obo:HP_0030809, obo:HP_0100765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002314 ; owl:someValuesFrom obo:UBERON_0007250 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000077 obo:IAO_0000115 "An abnormality of a mandible condylar process." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:19Z" ; oboInOwl:hasDbXref "UMLS:C4073284" ; oboInOwl:hasExactSynonym "Abnormality of mandible condylar process" ; oboInOwl:id "HP:3000077" ; a owl:Class ; rdfs:label "Abnormal mandible condylar process morphology" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0031816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004657 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000078 obo:IAO_0000115 "An abnormality of a mandible coronoid process." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:24Z" ; oboInOwl:hasDbXref "UMLS:C4073285" ; oboInOwl:hasExactSynonym "Abnormality of mandible coronoid process" ; oboInOwl:id "HP:3000078" ; a owl:Class ; rdfs:label "Abnormal mandible coronoid process morphology" ; rdfs:subClassOf obo:HP_0000277, obo:HP_0031816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0004660 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_3000079 obo:IAO_0000115 "A structural abnormality of a mandibular symphysis." ; dcterms:creator ; oboInOwl:creation_date "2015-08-07T03:39:28Z" ; oboInOwl:hasDbXref "UMLS:C4073286" ; oboInOwl:hasExactSynonym "Abnormality of mandible symphysis" ; oboInOwl:id "HP:3000079" ; a owl:Class ; rdfs:label "Abnormal mandibular symphysis morphology" ; rdfs:subClassOf obo:HP_0001367, obo:HP_0011842, obo:HP_0031816 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0006606 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_4000001 obo:IAO_0000115 "Abnormal finding by magnetic resonance imaging (MRI), which uses non-ionizing radiation via a strong magnetic field and radio frequency energy to generate three dimensional images. This term comprises findings that are specific to MRI. Findings such as ventricular spetum defect that can be detected by multiple modalities should be coded separately." ; dc:date "2021-04-24T14:23:59Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal cardiac magnetic resonance imaging finding" ; rdfs:subClassOf obo:HP_0001627 . obo:HP_4000003 obo:IAO_0000115 "Increased duration of myocardial T2 time without gadolinium contrast. Elevated T2, which can detect myocardial edema." ; dc:date "2021-04-24T14:32:56Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Elevated myocardial native T2" ; rdfs:subClassOf obo:HP_4000001 . obo:HP_4000004 obo:IAO_0000115 "Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium." ; dc:date "2021-04-24T14:43:32Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Delayed myocardial gadolinium enhancement" ; a owl:Class ; rdfs:comment "LGE can be detected in post-infarct scars, inflammation, as well as non-ischemic CMP, cardiac neoplasm and storage diseases such as amyloidosis." ; rdfs:label "Myocardial late gadolinium enhancement" ; rdfs:subClassOf obo:HP_4000001 . obo:HP_4000005 obo:IAO_0000115 "Areas of high signal intensity in magnetic resonance imaging of the pericardium appearing around 10 minutes after injection of the intercellular contrast agent gadolinium." ; dc:date "2021-04-24T14:54:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Late gadolinium enhancement in the pericardium may be observed with pericardial inflammation." ; rdfs:label "Pericardial late gadolinium enhancement" ; rdfs:subClassOf obo:HP_0001697 . obo:HP_4000006 obo:IAO_0000115 "Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity." ; dc:date "2021-04-24T16:47:52Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Prolonged myocardial native T1" ; a owl:Class ; rdfs:label "Elevated myocardial native T1" ; rdfs:subClassOf obo:HP_4000001 . obo:HP_4000007 obo:IAO_0000115 "Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath." ; dc:date "2021-04-25T23:21:45Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Bronchial constriction", "Constriction of the bronchi" ; a owl:Class ; rdfs:label "Bronchoconstriction" ; rdfs:subClassOf obo:HP_0025427 . obo:HP_4000008 obo:IAO_0000115 "Pronuclei formation is a critical process during fertilisation. Normally, there are two pronuclei (2PN), including the paternal pronucleus and the maternal pronucleus, in the zygote after fertilisation. It is generally accepted that multiple pronuclei (MPN) formation is due to the abnormal extrusion of the second polar body or to abnormal fertilisation with multiple sperm. The MPN therefore can cause infertility and recurrent failure of IVF/ICSI." ; dc:date "2021-04-25T23:27:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Three pro-nuclei (3PN) prevalence among all pregnancies has been estimated to be approximately 1% to 3%, whereas it accounts for 15% to 18% of cytogenetically abnormal cases among spontaneous abortions." ; rdfs:label "Formation of multiple pronuclei during fertilization" ; rdfs:subClassOf obo:HP_0033335 . obo:HP_4000009 obo:IAO_0000115 "An excessive, irrational and debilitating fear to carry out a physical movement, due to a feeling of vulnerability to a painful injury or reinjury." ; dc:date "2021-04-25T23:41:10Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Kinesiophobia" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_4000010 obo:IAO_0000115 "Decreased renal tubular reabsorption of bicarbonate." ; dc:date "2021-04-29T17:27:57Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Impaired renal tubular reabsorption of bicarbonate" ; rdfs:subClassOf obo:HP_0011038 . obo:HP_4000011 obo:IAO_0000115 "A congenital human papillomavirus (HPV) infection of the newborn. Congential HPV infection can manifest as condyloma cuminata in the newborn." ; dc:date "2021-05-02T12:58:58Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "History of congenital HPV infection" ; rdfs:subClassOf obo:HP_0033623 . obo:HP_4000012 dc:date "2021-05-02T13:10:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Necrotizing ileitis" ; rdfs:subClassOf obo:HP_0032564 . obo:HP_4000013 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-1, a dermal cell adhesion molecule." ; dc:date "2021-05-02T14:18:54Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-desmoglein-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000014 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-3, a dermal cell adhesion molecule." ; dc:date "2021-05-02T14:22:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-desmoglein-3 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000015 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against envoplakin, a cytoskeletal linker protein that links intermediate filaments to cellular junctions." ; dc:date "2021-05-02T14:23:11Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-envoplakin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000016 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against periplakin." ; dc:date "2021-05-02T14:25:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-periplakin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000017 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-1." ; dc:date "2021-05-02T14:26:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-desmoplakin I antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000018 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-II." ; dc:date "2021-05-02T14:27:21Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-desmoplakin II antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000019 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against BP230." ; dc:date "2021-05-02T14:28:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen." ; rdfs:label "Anti-BP230 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000020 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against BP180." ; dc:date "2021-05-02T14:29:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen." ; rdfs:label "Anti-BP180 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000021 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-332." ; dc:date "2021-05-02T14:31:15Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-laminin 5 antibody positivity" ; a owl:Class ; rdfs:comment "Anti-laminin gamma1 pemphigoid (ALG1P) is an autoimmune subepidermal bullous disease characterized by autoantibodies to a 200-kDa acidic noncollagenous glycoprotein of the lower lamina lucida. In contrast, anti-laminin-332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies to various subunits of laminin-332 of the basement membrane." ; rdfs:label "Anti-laminin 332 antibody positivity" ; rdfs:subClassOf obo:HP_4000024 . obo:HP_4000022 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-6." ; dc:date "2021-05-02T14:31:25Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-laminin 6 antibody positivity" ; rdfs:subClassOf obo:HP_4000024 . obo:HP_4000023 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against laminin gamma-1." ; dc:date "2021-05-02T14:34:05Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anti-laminin gamma1 pemphigoid (ALG1P) is an autoimmune subepidermal bullous disease characterized by autoantibodies to a 200-kDa acidic noncollagenous glycoprotein of the lower lamina lucida. In contrast, anti-laminin-332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies to various subunits of laminin-332 of the basement membrane." ; rdfs:label "Anti-laminin gamma1 antibody positivity" ; rdfs:subClassOf obo:HP_4000024 . obo:HP_4000024 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against a laminin. Laminins are major components of the basement membrane." ; dc:date "2021-05-02T14:38:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-laminin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000025 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against an integrin. Integrins are a family of cell adhesion molecules with 24 known integrin heterodimers. Integrins transduce mechanical and biochemical signals from fibrotic extracellular matrix into the cell, activate latent TGFbeta, and subsequently modulate fibroblast adhesion, migration, and growth." ; dc:date "2021-05-02T14:41:03Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-integrin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000026 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transglutaminase 6." ; dc:date "2021-05-02T14:46:46Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-transglutaminase 6 antibody" ; rdfs:subClassOf obo:HP_0033563 . obo:HP_4000027 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against LAD-1, which is the soluble 120 kDa ectodomain of BP180." ; dc:date "2021-05-02T14:48:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by an autoimmune response to type XVII collagen (BP180). The generation of anti-BP180-NC16A IgG autoantibodies is considered to be central to the pathogenesis of BP, in part due to the close correlation between serum concentration and disease activity. However, about 60% of BP patients also generate IgG autoantibodies against LAD-1." ; rdfs:label "anti-LAD-1 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000028 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against LABD97, which is structurally identical to a portion of the extracellular domain of BPAg2. BPAg2, a 180 kDa bullous pemphigoid antigen, is a transmembrane protein important for basement membrane cohesion." ; dc:date "2021-05-02T14:52:23Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-LABD97 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000029 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against gliadin." ; dc:date "2021-05-02T14:57:22Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "AGA autoantibodies" ; a owl:Class ; rdfs:label "Antigliadin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000030 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against reticulin." ; dc:date "2021-05-02T15:01:52Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-reticulin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000031 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against collagen type VII." ; dc:date "2021-05-02T15:04:26Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Anti-type VII collagen may be detected in bullous pemphigoid patients at time of relapse." ; rdfs:label "Anti-type VII collagen antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000032 obo:IAO_0000115 "A perception that one's body is moving or swaying despite lack of motion of the body." ; dc:date "2021-05-02T15:07:55Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "False perception of self-motion" ; rdfs:subClassOf obo:HP_0001751 . obo:HP_4000033 obo:IAO_0000115 "A perception of unsteadiness of dizziness that is not characterized bythe spinning sensation of classic vertigo, but rather by an oscillatory perception (rocking, bobbing, or swaying despite the fact that the subject is not moving)." ; dc:date "2021-05-02T15:11:06Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "This feature can be observed in mal de debarquement syndrome and in vestibular paroxysmia." ; rdfs:label "Non-spinning vertigo" ; rdfs:subClassOf obo:HP_0001751 . obo:HP_4000034 obo:IAO_0000115 "Decreased lymphocyte count during infections." ; dc:date "2021-05-02T15:19:12Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Infection-associated lymphocytopenia" ; a owl:Class ; rdfs:label "Infection-associated lymphopenia" ; rdfs:subClassOf obo:HP_0040088 . obo:HP_4000035 obo:IAO_0000115 "Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction." ; dc:date "2021-05-02T19:57:12Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Primary obstructive megaureter" ; rdfs:subClassOf obo:HP_0000072 . obo:HP_4000036 obo:IAO_0000115 "A type of hydrocele testis in which both the proximal and distal portions of processus vaginalis get obliterated while the central portion remains patent and fluid accumulates within it." ; dc:date "2021-05-02T20:07:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Encysted hydrocele of the cord" ; rdfs:subClassOf obo:HP_0000034 . obo:HP_4000037 obo:IAO_0000115 "Congenital hydrocele occurs when processus vaginalis is patent and communicates with the peritoneal cavity. This communication allows the movement of peritoneal fluid but is too small to allow the intra-abdominal contents to herniate through." ; dc:date "2021-05-02T20:11:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Congenital hydrocele" ; rdfs:subClassOf obo:HP_0000034 . obo:HP_4000038 obo:IAO_0000115 "Infantile Hydrocele is a type pf hydrocele in which the processus vaginalis gets obliterated at the level of the deep inguinal ring. However, the portion distal to it remains patent and allows fluid accumulation." ; dc:date "2021-05-02T20:11:45Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Infantile hydrocele" ; rdfs:subClassOf obo:HP_0000034 . obo:HP_4000039 obo:IAO_0000115 "A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count." ; dc:date "2021-05-02T20:28:29Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Flow cytometry may identify MAIT cells as CD3+Valpha7+CD161hi or Tet-MR1+CD161hi." ; rdfs:label "Reduced proportion of mucosal-associated invariant T cells" ; rdfs:subClassOf obo:HP_0025540 . obo:HP_4000040 obo:IAO_0000115 "Onset of a phenotypic abnormality or a disease during childbirth or in the period immediately following." ; dc:date "2021-05-02T20:36:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Puerpural onset" ; rdfs:subClassOf obo:HP_0003674 . obo:HP_4000041 obo:IAO_0000115 "Extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein, a hepatic acute phase reactant." ; dc:date "2021-05-02T20:38:51Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "AA amyloidosis" ; rdfs:subClassOf obo:HP_0011034 . obo:HP_4000042 obo:IAO_0000115 "Category of fracture. Terms from this subontology can be used together with terms in the subontology that descends from Bone fracture (HP:0020110)." ; dc:date "2021-05-02T20:47:02Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Fracture type" ; rdfs:subClassOf obo:HP_0012823 . obo:HP_4000043 obo:IAO_0000115 "A type of fracture in which the broken bone is not completely separated." ; dc:date "2021-05-02T20:49:30Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Incomplete fracture" ; a owl:Class ; rdfs:label "Greenstick fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000044 obo:IAO_0000115 "A type of fracture in which the break is in a straight line across the bone." ; dc:date "2021-05-02T20:50:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Transverse fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000045 obo:IAO_0000115 "A type of fracture in which the break spirals around the bone." ; dc:date "2021-05-02T20:50:42Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Spiral fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000046 obo:IAO_0000115 "A type of fracture in which there is a diagonal break across the bone." ; dc:date "2021-05-02T20:51:13Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Oblique fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000047 obo:IAO_0000115 "A type of fracture in which the bone is crushed, causing the broken bone to be wider or flatter in appearance." ; dc:date "2021-05-02T20:51:49Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Wedge fracture" ; a owl:Class ; rdfs:label "Compression fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000048 obo:IAO_0000115 "A type of fracture in which the break is in three or more pieces and fragments are present at the fracture site." ; dc:date "2021-05-02T20:52:20Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Comminuted fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000049 obo:IAO_0000115 "A type of fracture in which the same bone is fractured in two places, so there is a floating segment of bone." ; dc:date "2021-05-02T20:52:50Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Segmental fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000050 obo:IAO_0000115 "A type of fracture in which there is an open wound or break in the skin near the site of the broken bone." ; dc:date "2021-05-02T20:54:29Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Compound fracture" ; a owl:Class ; rdfs:label "Open fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000051 obo:IAO_0000115 "A type of fracture in which the broken bone that does not penetrate the skin." ; dc:date "2021-05-02T20:55:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Closed fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000052 obo:IAO_0000115 "A type of fracture that is localied near to a a tendon or ligament and a small fragment of bone is separated from the main mass of bone as a result of physical trauma." ; dc:date "2021-05-02T20:56:24Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Avulsion fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000053 obo:IAO_0000115 "A type of fracture in which the ends of the fractured bone are no longer aligned." ; dc:date "2021-05-02T20:58:15Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Displaced fracture" ; rdfs:subClassOf obo:HP_4000042 . obo:HP_4000054 obo:IAO_0000115 "A widespread rash." ; dc:date "2021-05-02T21:41:36Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "An exanthem may be caused by an infection or represent a reaction to a toxin or an immune response and may be accompanied by symptoms such as fever, malaise and headache." ; rdfs:label "Exanthem" ; rdfs:subClassOf obo:HP_0000988 . obo:HP_4000055 obo:IAO_0000115 "A reaction characterizeds by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling localized to the in the intestinal tract." ; dc:date "2021-05-02T21:44:53Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Intestinal inflammation" ; rdfs:subClassOf obo:HP_0004386 . obo:HP_4000056 obo:IAO_0000115 "Any abnormality of programmed cell death (apoptosis), which is defined as the orchestrated collapse of a cell characterised by membrane blebbing, cell shrinkage, condensation of chromatin, and fragmentation of DNA followed by rapid engulfment of the corpse by neighbouring cells. Apoptosis is distinguished from death by necrosis by the absence of an associated inflammatory response." ; dc:date "2021-05-02T21:53:27Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal apoptosis" ; rdfs:subClassOf obo:HP_0011017 . obo:HP_4000057 obo:IAO_0000115 "A reduced amount of programmed cell death upon stimulation of the FAS receptor, which normally induces caspase-8 dependent apoptosis." ; dc:date "2021-05-02T21:55:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Decreased FasL-mediated apoptosis" ; rdfs:subClassOf obo:HP_4000056 . obo:HP_4000058 obo:IAO_0000115 """A type of proteinuria characterized by increased permeability of the glomerular capillary wall to macromolecules (particularly albumin), whereby protein excretion can reach 20 g/24 h and consists mainly of albumin. PMID: 19634399""" ; dc:date "2021-05-02T22:02:41Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "In contrast to glomerular proteinuria, tubular proteinuria is generally less than 1-2 g/24 h. In tubular proteinuria, although albumin remains a significant component, there is a relatively much greater increase in proteins of smaller than 60 000 Da" ; rdfs:label "Glomerular proteinuria" ; rdfs:subClassOf obo:HP_0000093 . obo:HP_4000059 obo:IAO_0000115 "A structural defect associated with abnormal development of the lung." ; dc:date "2021-06-09T12:13:11Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Developmental pulmonary anomaly" ; a owl:Class ; rdfs:label "Abnormal lung development" ; rdfs:subClassOf obo:HP_0002088 . obo:HP_4000060 dc:date "2021-06-09T12:17:33Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal pulmonary alveolar system development" ; rdfs:subClassOf obo:HP_0033137, obo:HP_4000059 . obo:HP_4000061 obo:IAO_0000115 "A diffuse and specific increase in the number of alpha-cells." ; dc:date "2021-06-23T16:27:00Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "Alpha cells are glucagon-secreting endocrine cells in the pancreatic islets of the pancreas." ; rdfs:label "Pancreatic alpha-cell hyperplasia" ; rdfs:subClassOf obo:HP_0004510 . obo:HP_4000062 obo:IAO_0000115 "A congenital hand malformation characterized by the coalescence of the coalescence of third and fourth metacarpals (i.e., those corresponding to the middle and ring fingers)." ; dc:date "2021-09-08T21:33:50Z"^^xsd:dateTime ; dcterms:creator ; oboInOwl:hasExactSynonym "Fused third and fourth metacarpals", "Middle and ring finger metacarpal synostosis", "Synostosis of third and the fourth metacarpal bones" ; a owl:Class ; rdfs:comment "Metacarpal synostosis is best described as a failure of differentiation causing a union between 2 adjacent metacarpals." ; rdfs:label "3-4 metacarpal synostosis" ; rdfs:subClassOf obo:HP_0009706, obo:HP_0009707 . obo:HP_4000066 obo:IAO_0000115 "Any structural anomaly of the iliac artery." ; dc:date "2021-11-24T01:28:09Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:comment "The common iliac artery originates from the aorta and divides into the internal and external iliac arteries, supplying oxygenated blood to the lower extremities (via the external iliac artery), the pelvis and its viscera (via internal iliac artery) as well as the peritoneum, psoas major muscle, ureter, and surrounding tissues." ; rdfs:label "Abnormal iliac artery morphology" ; rdfs:subClassOf obo:HP_0011004 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000051 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0005609 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_4000067 obo:IAO_0000115 "Abnormal outpouching or sac-like dilatation in the iliac artery." ; dc:date "2021-11-24T01:34:01Z"^^xsd:dateTime ; dcterms:creator ; a owl:Class ; rdfs:label "Iliac artery aneurysm" ; rdfs:subClassOf obo:HP_4000066 . obo:HP_4000068 obo:IAO_0000115 "Any deviation from normal intensity or subject of a person's interests, which can be defined as a state of giving selective attention to something." ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal interest" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_4000069 obo:IAO_0000115 "A type of abnormal interest characterized by a persistent and intense focus on parts of a toy/object. For example, affected individuals may spin the wheels on a toy car rather than drive the toy car." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Fixated interest in unusual objects", "Fixated interest with parts of objects", "Fixation with parts of objects" ; a owl:Class ; rdfs:label "Persistent preoccupation with parts of objects" ; rdfs:subClassOf obo:HP_5200108 . obo:HP_4000070 obo:IAO_0000115 "Highly restricted, fixated interests that are abnormal in intensity or focus (e.g., strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests)." ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Circumscribed interests", "Restricted interests" ; a owl:Class ; rdfs:label "Fixated interests" ; rdfs:subClassOf obo:HP_0031432 . obo:HP_4000072 obo:IAO_0000115 "The presence of any atypical form of expressive language." ; dc:date "2022-03-02T16:12:30Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Abnormal language feature" ; rdfs:subClassOf obo:HP_0034434 . obo:HP_4000073 obo:IAO_0000115 "Atypical language features characterized by first vs. second or third person pronoun errors such as using 'you' or 'he/she' in place of 'I'." ; dc:date "2022-03-02T16:13:45Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:comment "These errors are attested in normal toddlers' spontaneous speech, albeit at varying rates; pronouns typically emerge around 1.5 years of age and reversals are most common before 2.5 years. A higher rate of pronoun reversal may be expected of people with autism spectrum disorder." ; rdfs:label "Pronoun reversal" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_4000074 obo:IAO_0000115 "Consistent use of an unusual way of referring to something that is idiosyncratic to the individual." ; dc:date "2022-03-02T16:17:03Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Idiosyncratic language" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_4000075 obo:IAO_0000115 "The number of times facial expressions are produced in a given period is lower than expected given the social and cultural context." ; dc:date "2022-03-02T16:22:09Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced frequency of facial expressions" ; rdfs:subClassOf obo:HP_4000087 . obo:HP_4000076 obo:IAO_0000115 "Moving another person's hand, body part, or body to communicate a desire, e.g. pushing or pulling someone toward a desired object or placing someone's hand on something." ; dc:date "2022-03-02T16:24:26Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Hand-leading gesture", "Hand-taking gestures" ; a owl:Class ; rdfs:label "Use of another person's body to communicate" ; rdfs:subClassOf obo:HP_0000758 . obo:HP_4000077 obo:IAO_0000115 "A fixated interest in a specific topic that is atypical for the social context of the individual, such as topics of a non-social nature like fossils or vacuum cleaners." ; dc:date "2022-03-02T16:27:05Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; oboInOwl:hasExactSynonym "Unusual preoccupations" ; a owl:Class ; rdfs:label "Fixated interest with abnormal focus" ; rdfs:subClassOf obo:HP_4000070 . obo:HP_4000078 obo:IAO_0000115 "An abnormally intense interest in a topic or object that is not atypical for the social context of the affected person." ; dc:date "2022-03-02T16:37:04Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:comment "Typical examples of fixated interests with abnormal intensity include flipping the flag on a mailbox up and down repeatedly for long periods of time, taking a fork or other such objects everywhere, repeatedly lining up toys in the same order, or repeatedly reading information about a favorite topic such as a sports team." ; rdfs:label "Fixated interest with abnormal intensity" ; rdfs:subClassOf obo:HP_4000070 . obo:HP_4000079 obo:IAO_0000115 "Unusual interest in sensory aspects of the environment." ; dc:date "2022-03-02T16:43:23Z"^^xsd:dateTime ; dcterms:contributor , , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Sensory seeking" ; rdfs:subClassOf obo:HP_5200046 . obo:HP_4000080 obo:IAO_0100001 "HP:5200027" ; a owl:Class ; owl:deprecated true . obo:HP_4000081 obo:IAO_0000115 "Diminished use of typical non-verbal conversational gestures such as shaking the head to indicate no or nodding the head to indicate yes." ; dc:date "2022-03-02T16:49:23Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced production of gestures" ; rdfs:subClassOf obo:HP_4000090 . obo:HP_4000082 obo:IAO_0000115 "Impairment in a child's ability to be able to play in a way that involves peer collaboration. Collaborative play involves things such as verbal and non-verbal communication (e.g., self-initiated interactions), turn-taking, sharing, reciprocity, and collaborative problem-solving. It is often contrasted to parallel play, which involves a form of social play in which two children do similar activities near each other and often mimic each other. Typically developing children develop collaborative play between the ages of 4 and 5." ; dc:date "2022-03-02T16:54:46Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced collaborative play" ; rdfs:subClassOf obo:HP_5200104, obo:HP_5200136 . obo:HP_4000083 obo:IAO_0000115 "Lack of interest of an individual in peers of comparable age and social groups. For example, a child who is only interested in social interactions with adults rather than children their age." ; dc:date "2022-03-02T16:55:59Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Ignores peers" ; rdfs:subClassOf obo:HP_5200004, obo:HP_5200136 . obo:HP_4000084 obo:IAO_0000115 "Decreased sharing of interests with others appropriate to culture and developmental level." ; dc:date "2022-03-02T16:57:29Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced sharing of interests" ; rdfs:subClassOf obo:HP_5200027 . obo:HP_4000085 obo:IAO_0000115 "An absence or reduction in object sharing. Object sharing is an early emerging social skill in which a child will share objects with parents or peers during object play. Object sharing typically develops within the first two years of life." ; dc:date "2022-03-02T16:59:59Z"^^xsd:dateTime ; dcterms:contributor , , , ; dcterms:creator ; a owl:Class ; rdfs:label "Reduced object sharing" ; rdfs:subClassOf obo:HP_5200027 . obo:HP_4000087 obo:IAO_0000115 "Abnormal expressions (movements or position of muscles of the face that convey the emotional state of an individual to observers during social interactions) comprising abnormalities of quantity, range, context-appropriateness, and quality." ; dc:date "2022-08-18T12:34:20Z"^^xsd:dateTime ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Abnormal facial expression use" ; a owl:Class ; rdfs:comment "This term describes the way facial expressions are used for communicating to other people (social communication). This term does not comprise abnormal facial expressions related to motoric neurological deficits such as hypomimic facies observed in individuals with Parkinson syndrome." ; rdfs:label "Abnormal communicative facial expressions" ; rdfs:subClassOf obo:HP_0000758 . obo:HP_4000088 obo:IAO_0000115 "Production of facial expressions that are misaligned with the social context." ; dc:date "2022-08-18T12:41:20Z"^^xsd:dateTime ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Facial expressions that do not match the context" ; rdfs:subClassOf obo:HP_4000087 . obo:HP_4000089 obo:IAO_0000115 "Spontaneous production of communicative facial expressions that have poor quality or are exaggerated or muted." ; dc:date "2022-08-18T12:41:42Z"^^xsd:dateTime ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Atypical facial expressions" ; a owl:Class ; rdfs:comment "This feature does not include facial motor tics." ; rdfs:label "Abnormal quality of facial expression" ; rdfs:subClassOf obo:HP_4000087 . obo:HP_4000090 obo:IAO_0000115 "Abnormality in the use of gestures defined as hand, shoulder, and head movements that convey a shared meaning within a culture that replace or supplement verbal communication." ; dc:date "2022-08-18T13:17:50Z"^^xsd:dateTime ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Abnormal communicative gesture use", "Abnormal communicative gestures", "Abnormal gestures" ; a owl:Class ; rdfs:comment "Gestures refer to movements of the arms, hand, shoulders, or head and do not include facial expressions." ; rdfs:label "Abnormal gesture use" ; rdfs:subClassOf obo:HP_0000758 . obo:HP_4000092 obo:IAO_0000115 "Reduced ability to conduct a reciprocal (back and forth) conversation, as expected for language level. May be characterized by deficits in the ability to make comments about discussion topics of others, failure to ask questions, and not building a conversation on comments of others. Affected persons may not know what to say next in a conversation, may not notice if others are bored with a given topic, may conduct a one-sided conversation (talking but not listening), or may veer off topic more than is socially acceptable." ; dc:date "2022-08-29T13:04:27Z"^^xsd:dateTime ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Failure of normal back-and-forth conversation" ; a owl:Class ; rdfs:label "Poor conversational reciprocity" ; rdfs:subClassOf obo:HP_5200128, obo:HP_5200136 . obo:HP_4000093 obo:IAO_0000115 "A condition in which the permanent teeth, because of deficiency of growth in the jaw or segment of jaw, assume a path of eruption that intercepts a primary tooth, causes its premature loss and produces a consequent malposition of the permanent tooth." ; dc:date "2023-01-16T07:30:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Ectopic tooth eruption"@en ; rdfs:subClassOf obo:HP_0006292 . obo:HP_4000094 obo:IAO_0000115 "A developmental anomaly characterized by undergrowth of the corpus cavernosum." ; dc:date "2023-01-16T07:43:02Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Corpus cavernosum hypoplasia"@en ; rdfs:subClassOf obo:HP_0100623 . obo:HP_4000095 obo:IAO_0000115 "Concentration of the nucleobase thymine in the blood circulation above the normal range." ; dc:date "2023-01-16T07:48:07Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Elevated circulating thymine concentration"@en ; rdfs:subClassOf obo:HP_0004353 . obo:HP_4000100 obo:IAO_0000115 "Elevated hydrogen gas level in exhaled breath following oral administration of lactose. In individuals with lactose intolerance, undigested lactose in the colon will be metabolized by colonic bacteria, releasing hydrogen gas." ; dc:date "2023-01-16T09:09:11Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The enzyme lactase phlorizin hydrolase, located at the intestinal brush border, is necessary for the hydrolysis of lactose, the main sugar in milk. Due to the genetically programmed decrease in intestinal lactase activity that occurs post-weaning (lactase non-persistence), a large proportion of the human population loses, in adult age, the possibility to digest and absorb lactose." ; rdfs:label "Positive lactose hydrogen breath test"@en ; rdfs:subClassOf obo:HP_0012379 . obo:HP_4000101 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to a medication." ; dc:date "2023-01-16T09:10:52Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Triggered by exposure to medication"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_4000102 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to allopurinol." ; dc:date "2023-01-16T09:11:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Allopurinol exposure" ; a owl:Class ; rdfs:label "Triggered by allopurinol"@en ; rdfs:subClassOf obo:HP_4000101 . obo:HP_4000103 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by oral zinc supplementation." ; dc:date "2023-01-16T09:12:44Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Zinc oral supplementation produces improvement" ; a owl:Class ; rdfs:label "Ameliorated by oral zinc supplementation"@en ; rdfs:subClassOf obo:HP_0034536 . obo:HP_4000104 obo:IAO_0000115 "A root of a tooth that is more rounded than normal." ; dc:date "2023-01-16T09:27:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Dental roots curved" ; a owl:Class ; rdfs:label "Curved dental root"@en ; rdfs:subClassOf obo:HP_0006486 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0003677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] ] . obo:HP_4000105 obo:IAO_0000115 "The four-chamber (4Ch) view of the fetal heart is the most widely used screening examination for the detection of structural cardiac abnormalities during routine fetal ultrasonography. In the healthy normal fetus, the apical 4Ch view demonstrates four well-developed chambers, a concordant atrioventricular (AV) connection, unobstructed AV valves (mitral and tricuspid valves), the foramen ovale flap opening into left atrium (LA), and an intact interventricular septum. Additionally, the pulmonary venous opening can be visualized at the LA wall. Any structural deviations from normal anatomy may lead to congenital heart disease that can be determined by the 4Ch view of the fetal heart's ultrasound imaging." ; dc:date "2023-01-16T17:36:32Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Abnormal four chamber view" ; a owl:Class ; rdfs:label "Abnormal four chamber view of the fetal heart"@en ; rdfs:subClassOf obo:HP_0010948 . obo:HP_4000106 obo:IAO_0000115 "A hamartomatous lesion (benign focal lesions composed of disorganized tissue elements) localized in the spleen." ; dc:date "2023-01-16T17:40:36Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Spleen hamartoma"@en ; rdfs:subClassOf obo:HP_0010566 . obo:HP_4000107 obo:IAO_0000115 "Deposits of immunoglobulins and complement components along the dermoepidermal junction." ; dc:date "2023-01-16T17:42:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Lupus band test positive" ; a owl:Class ; rdfs:label "Positive lupus band test"@en ; rdfs:subClassOf obo:HP_0031538 . obo:HP_4000108 obo:IAO_0000115 "Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of erythroid precursors in the bone marrow." ; dc:date "2023-01-16T17:51:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Bone marrow: erythroid vacuolization" ; a owl:Class ; rdfs:comment "See Figure 1 of PMID:29716882." ; rdfs:label "Bone marrow erythroid vacuolization"@en ; rdfs:subClassOf obo:HP_0012130 . obo:HP_4000109 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to an electromagnetic field." ; dc:date "2023-01-17T08:44:37Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Electromagnetic field triggers symptoms" ; a owl:Class ; rdfs:label "Triggered by electromagnetic field"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_4000110 obo:IAO_0000115 "Information about current and past exposure to metals, dust, fibers, fumes, chemicals, biologic hazards, radiation, noise, and/or vibration at work or home." ; dc:date "2023-01-17T08:46:14Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Exposure history"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000111 obo:IAO_0000115 "History of exposure to asbestos, a fibrous mineral with physical and chemical properties that make it resistant to heat and degradation." ; dc:date "2023-01-17T08:48:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Mesothelioma is an occupational disease occurring as a result of asbestos exposure in the workplace." ; rdfs:label "Asbestos exposure"@en ; rdfs:subClassOf obo:HP_4000110 . obo:HP_4000112 obo:IAO_0000115 "Information about current or past medications taken by an individual." ; dc:date "2023-01-17T09:25:01Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Medication history"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000113 obo:IAO_0000115 "History of having taken aminoglycoside antibiotics." ; dc:date "2023-01-17T09:26:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "Aminoglycosides include gentamycin, tobramycin, amikacin, kanamycin, and streptomycin, and may be associated with ototoxicity." ; rdfs:label "Aminoglycoside exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000114 obo:IAO_0000115 "History of having taken statins, also known as HMG-CoA reductase inhibitors." ; dc:date "2023-01-17T09:28:37Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "HMG-CoA reductase inhibitors, or statins, are widely used for hyperlipidemia and cardiovascular disease." ; rdfs:label "Statin exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000115 obo:IAO_0000115 "History of having taken a potassium-sparing diuretic exposure such as amiloride, eplerenone, spironolactone, and triamterene." ; dc:date "2023-01-17T09:31:24Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Potassium-sparing diuretic exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000116 obo:IAO_0000115 "History of having taken carbamazepine." ; dc:date "2023-01-17T09:32:24Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Carbamazepine exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000117 obo:IAO_0000115 "History of having taken valproate (valproic acid)." ; dc:date "2023-01-17T09:33:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Valproate exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000118 obo:IAO_0000115 "History of having taken hydralazine." ; dc:date "2023-01-17T09:34:05Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Hydralazine exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000119 obo:IAO_0000115 "History of having taken a calcium channel blocker such as amlodipine, nicardipine, nifedipine, verapamil, or diltiazem." ; dc:date "2023-01-17T09:34:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Calcium channel blocking drug use" ; a owl:Class ; rdfs:label "Calcium channel blocker exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000120 dc:date "2023-01-18T07:19:42Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Contact with nickel" ; a owl:Class ; rdfs:comment "Applies to a sign or symptom that is provoked or brought about by exposure (cutaneous contact) to nickel." ; rdfs:label "Triggered by nickel"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_4000121 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure (cutaneous contact) to poison ivy, poison oak, and poison sumac. These three plants each contain urushiol. Contact with these plants is the most common causes of clinically diagnosed allergic contact dermatitis." ; dc:date "2023-01-18T07:23:05Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Contact with poison ivy, poison oak, or sumac" ; a owl:Class ; rdfs:label "Triggered by poison ivy, poson oak, or sumac"@en ; rdfs:subClassOf obo:HP_0025204 . obo:HP_4000122 obo:IAO_0000115 "A past medical history of having been fed exclusively by breast feeding." ; dc:date "2023-01-18T07:27:25Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Breast feeding, exclusive" ; a owl:Class ; rdfs:label "History of exclusive breast feeding"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000123 obo:IAO_0000115 "A part of the past medical history consisting of information about the typical food intake of an individual." ; dc:date "2023-01-18T07:37:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Nutrition history"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000124 obo:IAO_0000115 "A history of ingestion of a relatively high amount of foods containing high levels of oxalate, such as green-leaf vegetables, tea, nuts, chocolate and rhubarb." ; dc:date "2023-01-18T07:39:57Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Foods high in oxalate, high intake" ; a owl:Class ; rdfs:comment "An increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries." ; rdfs:label "High dietary oxalate intake"@en ; rdfs:subClassOf obo:HP_4000123 . obo:HP_4000125 obo:IAO_0000115 "A history of ingestion of honey in recent weeks." ; dc:date "2023-01-18T07:43:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Honey ingestion in recent weeks" ; a owl:Class ; rdfs:label "Recent honey ingestion"@en ; rdfs:subClassOf obo:HP_4000123 . obo:HP_4000126 obo:IAO_0000115 "A history of eating raw egg whites." ; dc:date "2023-01-18T07:45:03Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Raw egg-white ingestion"@en ; rdfs:subClassOf obo:HP_4000123 . obo:HP_4000127 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by administration of sodium channel blocking agents such as phenytoin, carbamazepine, oxcarbazepine, lamotrigine, topiramate, and zonisamide." ; dc:date "2023-01-18T07:46:52Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Sodium channel blocking drugs aggravate findings" ; a owl:Class ; rdfs:label "Exacerbated by sodium channel blocking agent exposure"@en ; rdfs:subClassOf obo:HP_4000176 . obo:HP_4000128 obo:IAO_0000115 "Addiction to inhaled nitrous oxide gas (N2O)." ; dc:date "2023-01-18T07:48:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Nitrous oxide abuse" ; a owl:Class ; rdfs:label "Nitric oxide addiction"@en ; rdfs:subClassOf obo:HP_0033511 . obo:HP_4000129 obo:IAO_0000115 "A past medical history of a recent blood transfusion." ; dc:date "2023-01-18T07:50:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Blood transfusion, recent" ; a owl:Class ; rdfs:label "Recent blood transfusion"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000130 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by administration of colchizine." ; dc:date "2023-01-18T07:54:01Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Colchicine ameliorates symptoms" ; a owl:Class ; rdfs:label "Ameliorated by colchicine"@en ; rdfs:subClassOf obo:HP_0034536 . obo:HP_4000131 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by administration of vitamin D." ; dc:date "2023-01-18T07:55:18Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vitamin D reduces manifestations" ; a owl:Class ; rdfs:label "Ameliorated by vitamin D"@en ; rdfs:subClassOf obo:HP_0034536 . obo:HP_4000132 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by administration of phenytoin." ; dc:date "2023-01-18T07:56:19Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Phenytoin produces worsening" ; a owl:Class ; rdfs:label "Exacerbated by phenytoin exposure"@en ; rdfs:subClassOf obo:HP_4000176 . obo:HP_4000133 obo:IAO_0000115 "Applies to a sign or symptom that is provoked or brought about by exposure to anngiotensin-converting enzyme inhibitor such as benazepril, captopril, enalapril, fosinopril, and lisinopril." ; dc:date "2023-01-18T07:57:47Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "ACE inhibitors trigger attacks" ; a owl:Class ; rdfs:label "Triggered by angiotensin-converting enzyme inhibitor"@en ; rdfs:subClassOf obo:HP_4000101 . obo:HP_4000134 obo:IAO_0000115 "History of having been treateed with prostaglandin E1." ; dc:date "2023-01-18T08:00:25Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Prostaglandin E1 exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000135 obo:IAO_0000115 "History of having been treated with 5-fluorouracil." ; dc:date "2023-01-18T08:02:17Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "5-fluorouracil exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000136 obo:IAO_0000115 "History of having been treateed with 6-mercaptopurine." ; dc:date "2023-01-18T08:03:10Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "6-mercaptopurine exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000137 obo:IAO_0000115 "History of having been treateed with isoniazid." ; dc:date "2023-01-18T08:04:02Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Isoniazid exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000138 obo:IAO_0000115 "The cavum septum pellucidum (CSP) is an important fetal midline forebrain landmark that is normally visible by prenatal sonography. This term refers to the lack of visiblity of the CSP on prenatal sonography. The CSP normally can be visualized between 18 and 37 weeks of gestation. Lack of visualization of the CSP in this time period generally requires follow up and may indicate the presence of underlying malformations such as malformations of the corpus callosum. The lack of CSP before 18 weeks or after 37 weeks of gestation (or postnatally) is considered a normal finding." ; dc:date "2023-01-18T19:01:30Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Absent cavum septum pellucidum"@en ; rdfs:subClassOf obo:HP_0007375, obo:HP_0034206 . obo:HP_4000139 obo:IAO_0000115 "Fetal abdominal cysts are usually detected during the second trimester anomaly scan or discovered incidentally at later gestations. However, a definitive diagnosis is often not made until postnatal life. The most common etiologies of fetal abdominal cysts are: ovarian, gastrointestinal cystic duplication, liver and choledochal, meconium pseudocysts, mesenteric and adrenal. Following identification of a cyst, careful morphological assessment allows the prediction of their natural history and importantly, the likelihood of surgical intervention being required postnatally." ; dc:date "2023-01-19T07:02:08Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Fetal cystic abdominal mass", "Foetal abdominal cyst", "Foetal cystic abdominal mass" ; a owl:Class ; rdfs:comment "Fetal ultrasound cannot always distinguish the origin of a cystic lesion in the abdominal region." ; rdfs:label "Fetal abdominal cyst"@en ; rdfs:subClassOf obo:HP_0034207 . obo:HP_4000140 obo:IAO_0000115 "Fetal bowel dilatation is characterized by fluid-filled intestinal loops which measure at least fifteen millimeters long or seven millimeters in diameter. Ultrasonographic image of dilated fetal bowel is a sign of intestinal mechanical or functional obstruction and its prevalence will depend on the underlying condition: bowel atresia or stenosis, malrotation with volvulus, meconium ileus, total colonic aganglionosis, and meconium plug syndrome. The etiology of fetal bowel dilatation is a difficult prenatal diagnosis since ultrasound has limited accuracy for bowel evaluation." ; dc:date "2023-01-19T07:12:40Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Foetal bowel dilatation", "Prenatal ultrasound: bowel loops dilated" ; a owl:Class ; rdfs:label "Fetal bowel dilatation"@en ; rdfs:subClassOf obo:HP_0034207 . obo:HP_4000141 obo:IAO_0000115 "Enlargement of the chamber of the left heart ventricle." ; dc:date "2023-01-19T07:23:27Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Dilated left heart ventricle" ; a owl:Class ; rdfs:label "Left ventricular dilatation"@en ; rdfs:subClassOf obo:HP_0001711 . obo:HP_4000142 obo:IAO_0000115 "A fetal ultrasound finding defined by flattening of the occiput with pointing of the frontal bones and brachycephaly with an increased cephalic index. It is characterized by keel shaped deformity of forehead with midline ridge, bilateral fronto temporal constriction with compensatory biparietal expansion, supra orbital and lateral orbital retrusion and hypotelorism. This finding is said to resemble a strawberry." ; dc:date "2023-01-19T07:27:53Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Foetal trigonocephaly", "Strawberry sign", "Strawberry skull", "Strawberry-shaped skull" ; a owl:Class ; rdfs:comment "Fetal trigonocephaly can be seen in trisomy 18 (or other chromosomal abnormalities) and monogenic syndromes, particularly also in craniosynostosis syndromes and some skeletal dysplasias." ; rdfs:label "Fetal trigonocephaly"@en ; rdfs:subClassOf obo:HP_0025662 . obo:HP_4000143 obo:IAO_0000115 "A prenatal anomaly of the outflow tract. Fetal ultrasound may not always be able to easily and accurately describe the outflow anomaly, but can detect abnormal anatomy. Often, follow up with a fetal echo is recommended, but fetal ultrasound is limited." ; dc:date "2023-01-19T07:38:07Z"^^xsd:dateTime ; a owl:Class ; rdfs:comment "The left ventricular outflow tract is the anatomic structure through which the left ventricular stroke volume passes towards the aorta. The right ventricular outflow tract is the structure through which the right ventricular stroke volume passes to the pulmonary artery." ; rdfs:label "Abnormal fetal heart outflow tract"@en ; rdfs:subClassOf obo:HP_0010948 . obo:HP_4000144 obo:IAO_0000115 "History of events that precede the current presenting condition and are thought to be of potential relevance, having occured in the hours, days, or weeks before the current condition." ; dc:date "2023-01-22T11:26:04Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Recent past medical history"@en ; rdfs:subClassOf obo:HP_0032443 . obo:HP_4000145 obo:IAO_0000115 "Medical history of a viral illness in recent weeks." ; dc:date "2023-01-22T11:27:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Antecedent viral illness" ; a owl:Class ; rdfs:label "History of recent viral illness"@en ; rdfs:subClassOf obo:HP_4000144 . obo:HP_4000146 obo:IAO_0000115 "Medical history of a dental procedure in recent weeks." ; dc:date "2023-01-22T12:02:34Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "History of recent dental procedure"@en ; rdfs:subClassOf obo:HP_4000144 . obo:HP_4000147 obo:IAO_0000115 "Any structural anomaly of the portal artery." ; dc:date "2023-01-22T12:05:38Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal portal artery morphology"@en ; rdfs:subClassOf obo:HP_0006707 . obo:HP_4000148 obo:IAO_0000115 "Abnormal increase in size of the portal arteries of the liver." ; dc:date "2023-01-22T12:07:40Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Portal artery hyperplasia"@en ; rdfs:subClassOf obo:HP_4000147 . obo:HP_4000149 obo:IAO_0000115 "Areas of necrotic tissue within a lymph node." ; dc:date "2023-01-22T12:20:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Necrosis in lymph node" ; a owl:Class ; rdfs:label "Lymph node necrosis"@en ; rdfs:subClassOf obo:HP_0002733 . obo:HP_4000150 obo:IAO_0000115 "Neurons that contain more than one nucleus." ; dc:date "2023-01-22T12:27:43Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Multinucleated neuron"@en ; rdfs:subClassOf obo:HP_0012757 . obo:HP_4000151 obo:IAO_0000115 "A history of an injury that occurred several hours, days, or weeks before the current presenting complaint and is located on the other side of the body relative to the current presenting complaint." ; dc:date "2023-01-25T10:09:12Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "History of recent cotralateral injury"@en ; rdfs:subClassOf obo:HP_4000144 . obo:HP_4000152 obo:IAO_0000115 "Occuring on the left and right in succession. This term can refer to alternating sides of the body (e.g., Alternating hemiplegia) or alternative sides of the visual field (e.g., some migraine auras)." ; dc:date "2023-01-25T10:17:39Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Alternating sides of the body" ; a owl:Class ; rdfs:label "Alternating laterality"@en ; rdfs:subClassOf obo:HP_0012831 . obo:HP_4000153 obo:IAO_0000115 "A benign tumor arising from the epithelial surface of the cervix and usually caused by Human Papillomavirus infection." ; dc:date "2023-01-25T10:25:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Cervix squamous papilloma" ; a owl:Class ; rdfs:label "Cervical squamous cell papilloma"@en ; rdfs:subClassOf obo:HP_0032241 . obo:HP_4000154 obo:IAO_0000115 "A benign smooth muscle neoplasm that arises in the liver." ; dc:date "2023-01-25T10:31:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Hepatic leiomyoma" ; a owl:Class ; rdfs:label "Liver leiomyoma"@en ; rdfs:subClassOf obo:HP_0002896 . obo:HP_4000158 obo:IAO_0000115 "Description of conditions in which only an incomplete but relatively high proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for incomplete, but high penetrance, but we suggest that this term be applied if at least 80 percent but less than 100 percent of individuals with the given genotype would manifest the disease with a full lifespan." ; dc:date "2023-01-26T17:14:28Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Typified by high penetrance"@en ; rdfs:subClassOf obo:HP_0003829 . obo:HP_4000159 obo:IAO_0000115 "Description of conditions in which only a moderate proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for moderate penetrance, but we suggest that this term be applied if at least 20 percent but less than 80 percent of individuals with the given genotype would manifest the disease with a full lifespan." ; dc:date "2023-01-26T17:18:16Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Typified by moderate penetrance"@en ; rdfs:subClassOf obo:HP_0003829 . obo:HP_4000160 obo:IAO_0000115 "Description of conditions in which only a low proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for low penetrance, but we suggest that this term be applied if at least some but less than 20 percent of carriers would manifest the disease with a full lifespan." ; dc:date "2023-01-26T17:19:09Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Typified by low penetrance"@en ; rdfs:subClassOf obo:HP_0003829 . obo:HP_4000162 obo:IAO_0000115 "Decreased activity of the enzyme succinyl-CoA 3-ketoacid CoA transferase." ; dc:date "2023-02-17T21:00:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "SCOT activity low in fibroblasts" ; a owl:Class ; rdfs:comment "Succinyl-CoA: 3-ketoacid CoA transferase (SCOT; EC 2.8.3.5, gene symbol OXCT1) is a mitochondrial homodimer essential for ketone body utilization." ; rdfs:label "Decreased Succinyl-CoA 3-ketoacid CoA transferase activity"@en ; rdfs:subClassOf obo:HP_0012379 . obo:HP_4000163 obo:IAO_0000115 "Reduced activity of the enzyme phytanoyl-CoA hydroxylase, which plays a role in the catabolism of phytanic acid, a branched-chain fatty acid that is a normal constituent of the human diet." ; dc:date "2023-02-17T21:07:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "PhyH activity low in fibroblasts" ; a owl:Class ; rdfs:label "Decreased phytanoyl-CoA hydroxylase activity"@en ; rdfs:subClassOf obo:HP_0012379 . obo:HP_4000164 obo:IAO_0000115 "Diminished activity of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4), also known as D-bifunctional protein (DBP), a peroxisomal enzyme that catalyzes multiple steps of beta-oxidation of very long chain fatty acids." ; dc:date "2023-02-17T21:09:29Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Reduced 17-beta-hydroxysteroid dehydrogenase 4 activity" ; a owl:Class ; rdfs:label "Reduced bifunctional protein activity"@en ; rdfs:subClassOf obo:HP_0012379 . obo:HP_4000165 obo:IAO_0000115 "Reduced plasmalogen concentration in the blood circulation." ; dc:date "2023-02-17T21:35:55Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Reduced circulating plasmalogen concentration" ; a owl:Class ; rdfs:comment "Plasmalogens are a class of membrane glycerophospholipids that contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position." ; rdfs:label "Decreased circulating plasmalogen concentration"@en ; rdfs:subClassOf obo:HP_0040176 . obo:HP_4000166 obo:IAO_0000115 "Infection with live, attenuated varicella-zoster virus following vaccination. This is an extreemely rare event that may indicate immunocompromise." ; dc:date "2023-02-17T21:40:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Varicella zoster virus infection after vaccination" ; a owl:Class ; rdfs:label "Post-vaccination varicella zoster virus infection"@en ; rdfs:subClassOf obo:HP_0020085 . obo:HP_4000167 obo:IAO_0000115 "History of having been treated with corticosteroid medications in recent weeks." ; dc:date "2023-02-17T22:08:45Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "History of recent steroid use" ; a owl:Class ; rdfs:label "Recent steroid exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000168 obo:IAO_0000115 "Eruption of permanent teeth behind deciduous (baby) teeth before they have fallen out, resulting in a double row of teeth. This phenomen is typically observed between the ages of 5 to 7 years." ; dc:date "2023-02-17T22:12:00Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Cauliflower teeth", "Double-parked teeth", "Teeth: double row" ; a owl:Class ; rdfs:label "Shark teeth"@en ; rdfs:subClassOf obo:HP_0006292 . obo:HP_4000169 obo:IAO_0000115 "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the pons." ; dc:date "2023-02-17T22:18:17Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Pontine T2 hypointensity"@en ; rdfs:subClassOf obo:HP_0007361 . obo:HP_4000170 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against antigens present on the surface of thrombocytes such as the glycoproteins GPIIb/IIIa, GPIb/IX, and GPIa/IIa." ; dc:date "2023-02-17T22:32:33Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Antiplatelet antibodies present" ; a owl:Class ; rdfs:label "Anti-platelet antigen antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000171 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the serum that react against a voltage-gated potassium channel." ; dc:date "2023-02-17T22:35:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Voltage gated potassium channel antibodies in blood" ; a owl:Class ; rdfs:comment "Voltage-gated potassium channels represent a family of transmembrane channels responsible for returning the depolarized cell to a resting state after each nerve impulse." ; rdfs:label "Anti-voltage-gated potassium channel antibody positivity"@en ; rdfs:subClassOf obo:HP_0030057 . obo:HP_4000172 obo:IAO_0000115 "A history of following a vegan diet characterized by avoidance of food sourced from animals including meet, fish, and dairy products." ; dc:date "2023-02-17T23:02:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Vegan diet"@en ; rdfs:subClassOf obo:HP_4000123 . obo:HP_4000173 obo:IAO_0000115 "One or more previous pregnancies in which the fetus developed hydrops fetalis." ; dc:date "2023-02-17T23:04:51Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "History of hydrops fetalis in newborn offspring" ; a owl:Class ; rdfs:label "History of previous pregnancy with hydrops fetalis"@en ; rdfs:subClassOf obo:HP_0032467 . obo:HP_4000174 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by ingesting a potassium supplement." ; dc:date "2023-02-19T16:19:21Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Potassium supplements alleviate attacks" ; a owl:Class ; rdfs:label "Ameliorated by potassium supplements"@en ; rdfs:subClassOf obo:HP_0025254 . obo:HP_4000175 obo:IAO_0000115 "Applies to a sign or symptom that is improved or made more bearable by ingesting niacin (vitamin B3)." ; dc:date "2023-02-19T16:20:58Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Ameliorated by vitamin B3", "Niacin reverses symptoms" ; a owl:Class ; rdfs:label "Ameliorated by niacin"@en ; rdfs:subClassOf obo:HP_0025254 . obo:HP_4000176 obo:IAO_0000115 "Applied to a sign or symptom that is worsened by treatment with a medication." ; dc:date "2023-02-19T16:22:53Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Aggravated by exposure to medication"@en ; rdfs:subClassOf obo:HP_0025285 . obo:HP_4000177 obo:IAO_0000115 "Applies to bleeding that is significantly reduced by treatment with vitamin K." ; dc:date "2023-02-19T16:25:49Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Vitamin K treatment reduces bleeding significantly" ; a owl:Class ; rdfs:label "Bleeding ameliorated by vitamin K"@en ; rdfs:subClassOf obo:HP_0034536 . obo:HP_4000178 obo:IAO_0000115 "History of having been treated with an antiretroviral agent." ; dc:date "2023-02-19T16:28:42Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Anti-retroviral therapy exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000179 obo:IAO_0000115 "History of having been treated with a potassium-wasting diuretic such as thiazide (chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide, metolazone) and loop (bumetanide, ethacrynic acid, furosemide, torsemide) diuretics." ; dc:date "2023-02-19T16:30:55Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Potassium-wasting diuretic exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000180 obo:IAO_0000115 "History of having been treated with a tricyclic antidepressant medication." ; dc:date "2023-02-19T16:33:59Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Tricyclic antidepressant use" ; a owl:Class ; rdfs:label "Tricyclic antidepressant exposure"@en ; rdfs:subClassOf obo:HP_4000112 . obo:HP_4000181 obo:IAO_0000115 "A higher than expected amount of attrition of teeth, as menifested by loss of tooth characteristics including rounding or sharpening of incisal edges, loss of cusps, and fracturing of teeth, to an extent that is deemed more than would be expected at a given age." ; dc:date "2023-02-19T16:40:36Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Excessive tooth attrition", "Excessive wear and tear on teeth" ; a owl:Class ; rdfs:label "Excessive dental attrition"@en ; rdfs:subClassOf obo:HP_0006482 . obo:HP_4000182 obo:IAO_0000115 "Pain improves or worsens with changes in body position." ; dc:date "2023-02-19T16:44:38Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Positional nature to pain" ; a owl:Class ; rdfs:label "Positionally dependent pain"@en ; rdfs:subClassOf obo:HP_0025280 . obo:HP_4000183 obo:IAO_0000115 "Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) outside of the normal range." ; dc:date "2023-05-05T02:19:21Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Abnormal erythrocyte adenosine triphosphate concentration"@en ; rdfs:subClassOf obo:HP_0001877 . obo:HP_4000184 obo:IAO_0000115 "Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) below the lower limit of normal." ; dc:date "2023-05-05T02:20:54Z"^^xsd:dateTime ; a owl:Class ; rdfs:label "Reduced erythrocyte adenosine triphosphate concentration"@en ; rdfs:subClassOf obo:HP_4000183 . obo:HP_4000186 obo:IAO_0000115 "Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) above the upper limit of normal." ; dc:date "2023-05-05T04:39:34Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "Adenosine triphosphate (ATP) high in erythrocytes" ; a owl:Class ; rdfs:label "Elevated erythrocyte adenosine triphosphate concentration"@en ; rdfs:subClassOf obo:HP_4000183 . obo:HP_5000000 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-adenylate kinase 5 (AK5)." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-AK5 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000001 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody" ; a owl:Class ; rdfs:label "Anti-AMPAR antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000002 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Amphiphysin." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Amphiphysin antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000003 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Rho GTPase-activating protein 26 (ARHGAP26)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ca antibody", "Anti-RhoGTPase-activating protein 26 antibody" ; a owl:Class ; rdfs:label "Anti-ARHGAP26 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000004 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Carbonic anhydrase-related protein VIII (CARPVIII)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti CARPVIII antibody", "Anti-carbonic anhydrase-related protein VIII antibody" ; a owl:Class ; rdfs:label "Anti-CARP VIII antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000005 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against contactin-associated protein-like 2 (CASPR2)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Caspr2 antibody", "Anti-contactin-associated protein-like 2 antibody" ; a owl:Class ; rdfs:label "Anti-CASPR2" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000006 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CV2/CRMP5. Anti-CV2/CRMP5 autoantibody is the most commonly detected anti-neuronal autoantibody. Patients with typical paraneoplastic chorea show fully developed chorea in the course of weeks to months with acute inflammation in the striatum." ; dcterms:creator ; oboInOwl:hasAlternativeId "HP:5000041" ; oboInOwl:hasExactSynonym "Anti-CV2 antibody", "Anti-CV2/collapsin response mediator protein (CRMP)5 antibody", "Anti-collapsin response-mediated protein 5 antibody" ; a owl:Class ; rdfs:label "Anti-CV2/CRMP5 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000007 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dipeptidyl-peptidase-like protein 6 (DPPX)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-dipeptidyl-peptidase-like protein 6 antibody" ; a owl:Class ; rdfs:label "Anti-DPPX antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000008 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against FGFR3." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-fibroblast growth factor receptor 3 antibody" ; a owl:Class ; rdfs:label "Anti-FGFR3 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000009 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid A receptor, i.e., GABA(A)R." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-GABAA R antibody", "Anti-gamma amino butyric acid type A receptors antibody" ; a owl:Class ; rdfs:label "Anti-GABA(A)R antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000010 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid B receptor, i.e., GABA(B)R." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-gamma-aminobutyric acid B receptor antibody" ; a owl:Class ; rdfs:label "Anti-GABA(B)R antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000011 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamic acid decarboxylase 65 (GAD65)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-glutamic acid decarboxylase 65 antibody" ; a owl:Class ; rdfs:label "Anti-GAD65 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000012 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Gephyrin." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Gephyrin antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000013 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glial fibrillary acidic protein (GFAP)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-glial fibrillary acidic protein antibody" ; a owl:Class ; rdfs:label "Anti-GFAP antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000014 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Glycine receptor (GlyR)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-glycine receptor antibody" ; a owl:Class ; rdfs:label "Anti-GlyR antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000015 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Homer-3." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Homer protein homolog 3 antibody" ; a owl:Class ; rdfs:label "Anti-Homer-3 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000016 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Hu." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-ANNA-1 antibody", "Anti-Neuronal Nuclear Antibody type-1 antibody" ; a owl:Class ; rdfs:label "Anti-Hu antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000017 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against immunoglobulin-like cell adhesion molecule 5 (IgLON5)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-immunoglobulin-like cell adhesion molecule 5 antibody" ; a owl:Class ; rdfs:label "Anti-Iglon5 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000018 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against inositol 1,4,5-trisphosphate receptor 1 (ITPR1)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-inositol 1,4,5-trisphosphate receptor type 1 antibody" ; a owl:Class ; rdfs:label "Anti-ITPR1 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000019 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against kelch-like protein 11 (KLHL11)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-KLHL11 antibody" ; a owl:Class ; rdfs:label "Anti-Kelch like protein 11 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000020 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against leucine-rich glioma-inactivated 1 (LGI1)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Anti-leucine-rich glioma-inactivated 1 antibody" ; a owl:Class ; rdfs:label "Anti-LGI1 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000021 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Ma antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000022 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma2." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Ta antibody" ; a owl:Class ; rdfs:label "Anti-Ma2 antibody positivity" ; rdfs:subClassOf obo:HP_5000021 . obo:HP_5000023 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma1." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Ma1 antibody positivity" ; rdfs:subClassOf obo:HP_5000021 . obo:HP_5000024 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 1 (mGluR1)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-metabotropic glutamate receptor 1 antibody" ; a owl:Class ; rdfs:label "Anti-mGluR1 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000025 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 5 (mGluR5)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Metabotropic Glutamate Receptor Type 5 antibody" ; a owl:Class ; rdfs:label "Anti-mGluR5 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000026 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neurexin-3alpha." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-neurexin-3alpha antibody" ; a owl:Class ; rdfs:label "Anti-neurexin-3alpha antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000027 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against P/Q-type voltage-gated calcium channels (VGCCs)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-P/Q-type voltage-gated calcium-channel antibody" ; a owl:Class ; rdfs:label "Anti-P/Q-type VGCC antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000028 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against microtubule-associated protein 1B (MAP1B)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Purkinje cell cytoplasmic type-2 antibody", "Anti-microtubule-associated protein 1B antibody" ; a owl:Class ; rdfs:label "Anti-MAP1B antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000029 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against protein kinase Cgamma." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Protein kinase C gamma antibody" ; a owl:Class ; rdfs:label "Anti-PKCgamma antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000030 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ri, an antineuronal antibody." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-ANNA-2 antibody" ; a owl:Class ; rdfs:label "Anti-Ri antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000031 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Septin-5." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Septin-5 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000032 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against seizure-related 6 homolog like 2 (SEZ6L2)." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-SEZ6L2 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000033 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SOX1. Anti-SOX1 antibodies, also known as antiglial nuclear antibody (AGNA), are specifically found in paraneoplastic neurological disorders. Since SOX1 is expressed in neuronal precursor cells in the developing central nervous system, it has been used as an early marker of neural stem cells." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Sry-like high mobility group box (SOX) 1 antibody" ; a owl:Class ; rdfs:label "Anti-SOX1 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000034 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Tr/DNER. Anti-Tr antibodies are directed against cerebellar Purkinje cells (termed anti-Tr or PCA-Tr). Anti-Tr autoantibodies are frequently associated with Hodgkin lymphoma (HL). Anti-Tr antibodies are defined by a specific staining pattern in cerebellar tissue that is characterized by punctate immunoreactivity in both the dendritic tree and soma of Purkinje cells but not in their axons. This characteristic pattern is indicative of the presence of anti-Tr antibodies. The Delta/Notch-like epidermal growth factor-related receptor (DNER) was identified as the target antigen of anti-Tr." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-delta/notch-like epidermal growth factor-related receptor antibody", "PCA-Tr" ; a owl:Class ; rdfs:label "Anti-Tr/DNER antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000035 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the axon initial segment protein tripartite motif 46 (TRIM46)." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-TRIM46 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000036 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against TRIM9/TRIM67." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-TRIM9/TRIM67 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000037 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Yo." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Purkinje cell cytoplasmic antibody 1" ; a owl:Class ; rdfs:label "Anti-Yo antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000038 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against titin." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-titin antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000039 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Zic family member 4 (ZIC4)." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Zic4 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000041 obo:IAO_0100001 "HP:5000006" ; a owl:Class ; rdfs:label "obsolete Anti-CRMP5 antibody positivity" ; owl:deprecated true . obo:HP_5000042 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Sj/inositol 1,4,5-trisphosphate receptor." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-Sj/inositol 1,4,5-trisphosphate receptor antibody" ; a owl:Class ; rdfs:label "Anti-Sj/ITPR1 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000043 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dopamine-2 receptor." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-dopamine-2 receptors (D2R) antibody" ; a owl:Class ; rdfs:label "Anti-D2 R antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000044 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamate kainate receptor subunit 2 (GluK2)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-glutamate kainate receptor subunit 2 antibody" ; a owl:Class ; rdfs:label "Anti-GluK2 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000045 obo:IAO_0100001 "HP:0030210" ; dcterms:creator ; a owl:Class ; rdfs:label "obsolete Anti-MuSK antibody positivity" ; owl:deprecated true . obo:HP_5000046 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against low-density lipoprotein receptor (Lrp4)." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-low-density lipoprotein receptor-related protein 4 antibody" ; a owl:Class ; rdfs:label "Anti-Lrp4 antibody positivity" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000047 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ryanodine receptor." ; dcterms:creator ; oboInOwl:hasExactSynonym "Anti-RyR antibody" ; a owl:Class ; rdfs:label "Anti-ryanodine receptor antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5000048 obo:IAO_0000115 "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the voltage-gated potassium channel Kv1.4." ; dcterms:creator ; a owl:Class ; rdfs:label "Anti-Kv1.4 antibody" ; rdfs:subClassOf obo:HP_0030057 . obo:HP_5200001 obo:IAO_0000115 "Voluntary failure to use spoken language (at whatever level attained) in selective social contexts over a period of time." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Selective mutism" ; rdfs:subClassOf obo:HP_0034434 . obo:HP_5200002 obo:IAO_0000115 "An abnormally limited range of facial expressions demonstrated by a lack of nuance of facial expression to match specific social situations or an inability to demonstrate a normal range of emotions with one's face." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Reduced range of facial expressions" ; a owl:Class ; rdfs:label "Limited repertoire of facial expression" ; rdfs:subClassOf obo:HP_4000087 . obo:HP_5200003 obo:IAO_0000115 "An unusually strong interest in others in general or tendency to develop a strong interest in certain individuals." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Excessive interest in others" ; rdfs:subClassOf obo:HP_5200020 . obo:HP_5200004 obo:IAO_0000115 "A reduced interest in all people including both peers and non-peers." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Ignores others" ; a owl:Class ; rdfs:label "Reduced response to another's attempt to get direct attention" ; rdfs:subClassOf obo:HP_0012760 . obo:HP_5200005 obo:IAO_0000115 "Abnormally high or low-pitched vocalization or speech." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal pitch" ; rdfs:subClassOf obo:HP_5200010 . obo:HP_5200006 obo:IAO_0000115 "Speech characterized by weak (e.g. tangential/circumstantial) or absent (e.g. word salad) connections between ideas." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Loose association" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_5200007 obo:IAO_0000115 "Consistent use of an invented word that is unique to an individual." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Neologism" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_5200008 obo:IAO_0000115 "Use of language that is overly formal, precise, detailed, or pedantic for the social context." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Overly formal/pedantic language" ; rdfs:subClassOf obo:HP_4000072 . obo:HP_5200009 obo:IAO_0000115 "Hand stereotypies within the medial plane of the body." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Midline hand movements" ; rdfs:subClassOf obo:HP_5200018 . obo:HP_5200010 obo:IAO_0000115 "Abnormal rise and fall of the voice in speech and vocalization." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal Intonation" ; rdfs:subClassOf obo:HP_0031434 . obo:HP_5200011 obo:IAO_0000115 "Speech that is abnormally fast or slow" ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal speech rate" ; rdfs:subClassOf obo:HP_0031434 . obo:HP_5200012 obo:IAO_0000115 "Speech with abnormal rhythm or pattern" ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal speech rhythm" ; rdfs:subClassOf obo:HP_0031434 . obo:HP_5200013 obo:IAO_0000115 "Spontaneous production of communicative facial expressions that have poor quality or are perceived as odd or mechanical. This may include inaccurate mimicry of typical facial expressions. These expressions may be difficult to interpret for someone who is not familiar with the individual making the expression." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Ambiguous facial expression" ; rdfs:subClassOf obo:HP_4000089 . obo:HP_5200014 obo:IAO_0000115 "A tendency to make facial expressions that are exaggerated and a failure to make subtle facial expressions in a social context when a subtle expression is more appropriate." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Exaggerated facial expression" ; rdfs:subClassOf obo:HP_4000089 . obo:HP_5200015 obo:IAO_0000115 "A tendency to produce facial expressions with decreased intensity or expressivity which appear muted or flat." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Flat facial expression" ; a owl:Class ; rdfs:label "Muted facial expression" ; rdfs:subClassOf obo:HP_4000089 . obo:HP_5200016 obo:IAO_0000115 "The state of having abnormal relationships with others. This does not describe specific aspects of one's social aptitudes but rather a state which may come about from these aptitudes, such as lacking peer relationships or lacking close friends." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal peer relationships" ; rdfs:subClassOf obo:HP_5200024 . obo:HP_5200017 obo:IAO_0000115 "Abnormal movements of face and head." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Abnormal movements of face and head" ; rdfs:subClassOf obo:HP_0000733 . obo:HP_5200018 obo:IAO_0000115 "Abnormal movements of the upper extremities." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Abnormal movements of the upper extremities" ; rdfs:subClassOf obo:HP_0000733 . obo:HP_5200019 obo:IAO_0000115 "Abnormal movements of the whole body." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Abnormal movements of the whole body" ; rdfs:subClassOf obo:HP_0000733 . obo:HP_5200020 obo:IAO_0000115 "A social interest in others that is abnormal given the social context. This can include an increased interest with another person or an abnormal lack of interest in other people." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal interest in others" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_5200021 obo:IAO_0000115 "A lack of awareness or failure to apply social rules in multiple social settings which are simple or intuitive to others in the same social setting." ; dcterms:contributor , , , ; oboInOwl:hasAlternativeId "HP:5200025" ; oboInOwl:hasExactSynonym "Abnormal social awareness", "Abnormal social understanding" ; a owl:Class ; rdfs:label "Reduced social insight" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_5200022 obo:IAO_0000115 "Reduced awareness of expected conventions which are normal and expected for particular social settings or interactions." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Reduced awareness of convention" ; rdfs:subClassOf obo:HP_5200021, obo:HP_5200123 . obo:HP_5200024 obo:IAO_0000115 "The state of having abnormal relationships with others. This does not describe specific aspects of one's social aptitudes but rather a state which may come about from these aptitudes, such as lacking peer relationships, lacking close friends, or having a relational network that is abnormal given one's cultural context." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal relationship" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_5200025 obo:IAO_0100001 "HP:5200021" ; a owl:Class ; rdfs:label "obsolete Abnormal social awareness" ; owl:deprecated true . obo:HP_5200026 obo:IAO_0000115 "A reduced ability to imitate a task or the movements of others." ; dcterms:contributor , , , ; oboInOwl:hasAlternativeId "HP:5200032" ; oboInOwl:hasNarrowSynonym "Deferred imitation of others", "Reduced immediate imitation of others" ; a owl:Class ; rdfs:comment "The ability to imitate others is common in children during early cognitive development (4-5 years old) and can be abnormal in children with autism." ; rdfs:label "Abnormal social imitation" ; rdfs:subClassOf obo:HP_0012760 . obo:HP_5200027 obo:IAO_0000115 "An abnormality in one's tendency to initiate social interactions." ; dcterms:contributor , , , , ; oboInOwl:hasAlternativeId "HP:4000080" ; oboInOwl:hasNarrowSynonym "Reduced social initiation" ; a owl:Class ; rdfs:comment "This can be seen in patients with long-standing social deficits as is seen in autism and can be seen in episodic disorders such as a severe depressive episode." ; rdfs:label "Reduced attempt to get or direct another's attention" ; rdfs:subClassOf obo:HP_0012760 . obo:HP_5200028 obo:IAO_0000115 "Abnormality in the way one responds to social cues such as a verbal cue (which should cause one to shift attention) or someone sharing their emotions (which should elicit a sympathetic response)." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Reduced response to social cues" ; rdfs:subClassOf obo:HP_5200103 . obo:HP_5200029 dcterms:contributor , , , ; a owl:Class ; rdfs:label "Social disinhibition" ; rdfs:subClassOf obo:HP_0000734, obo:HP_5200123 . obo:HP_5200030 obo:IAO_0000115 "A communicative abnormality where one's nonverbal and verbal communication are poorly integrated. This may occur when verbal and nonverbal communication are intact alone but are abnormal when used together, or an abnormality in the use of typically integrated communication such as the use of beat gestures during speech." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Diminished integration of verbal and non-verbal communicative behavior" ; rdfs:subClassOf obo:HP_0034434 . obo:HP_5200031 obo:IAO_0100001 "HP:5200026" ; a owl:Class ; rdfs:label "obsolete Deferred imitation of others" ; owl:deprecated true . obo:HP_5200032 obo:IAO_0100001 "HP:5200026" ; a owl:Class ; rdfs:label "obsolete Reduced immediate imitation of others" ; owl:deprecated true . obo:HP_5200035 obo:IAO_0000115 "Failure of a child to integrate with peers in imaginative play." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Reduced collaborative imaginative play" ; rdfs:subClassOf obo:HP_5200105, obo:HP_5200136 . obo:HP_5200036 obo:IAO_0000115 "A consistent failure to make any response to verbal cues." ; dcterms:contributor , , , ; a owl:Class ; rdfs:comment "This term describes a behavioral abnormality and does not apply to those who do not respond to cues due to hearing impairment." ; rdfs:label "Lack of response to verbal cues" ; rdfs:subClassOf obo:HP_0012760 . obo:HP_5200037 obo:IAO_0000115 "A reduction in showing sympathy to others, such as providing comfort when someone is sad or crying." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Reduced sympathetic expression" ; rdfs:subClassOf obo:HP_0012760, obo:HP_5200120 . obo:HP_5200038 obo:IAO_0000115 "Slow speech." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Bradylogia" ; a owl:Class ; rdfs:label "Bradylalia" ; rdfs:subClassOf obo:HP_5200011 . obo:HP_5200039 obo:IAO_0000115 "Speech which is abnormally loud that is not due to a structural or muscular abnormality." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Speech too loud for context" ; a owl:Class ; rdfs:label "Excessively loud speech" ; rdfs:subClassOf obo:HP_5200043 . obo:HP_5200040 obo:IAO_0000115 "Speech which is abnormally quiet or inappropriate whispering that is not due to a structural or muscular abnormality." ; dcterms:contributor , , , ; oboInOwl:hasExactSynonym "Excessively soft voice", "Speech to soft for context" ; a owl:Class ; rdfs:label "Excessively quiet voice" ; rdfs:subClassOf obo:HP_5200043 . obo:HP_5200043 obo:IAO_0000115 "Speech that is abnormally loud or quiet for the social context in which it is spoken." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Abnormal speech volume" ; rdfs:subClassOf obo:HP_0002167 . obo:HP_5200044 obo:IAO_0000115 "Abnormality in one's ability to control their attention toward a specific subject or task. This could include the inability to change attention or hold attention." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Reduced attention regulation" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_5200045 obo:IAO_0000115 "Reduced ability to control, or a failure to resist a temptation, urge, or impulse." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Impaired self-restraint", "Impulse control disorders" ; a owl:Class ; rdfs:label "Reduced impulse control" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_5200046 obo:IAO_0000115 "Abnormal sensory behavior, including avoiding or seeking sensory input or difficulty modulating sensory stimuli." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Sensory behavioral abnormality" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_5200047 obo:IAO_0000115 "When one uses gestures that are unique to them and have no apparent meaning to others." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Idiosyncratic gesture" ; rdfs:subClassOf obo:HP_0034481 . obo:HP_5200049 obo:IAO_0000115 "Atypical focus on arranging, balancing, or positioning objects; may be atypical in focus or intensity." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Arranging", "Ordering" ; a owl:Class ; rdfs:label "Atypical sorting" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_5200050 obo:IAO_0000115 "Checking behavior that is excessive for the situational context." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Checking behaviors", "Checking behaviours" ; a owl:Class ; rdfs:label "Excessive checking" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_5200051 obo:IAO_0000115 "Hand washing behavior that is excessive for the situational context." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Excessive hand washing" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_5200052 obo:IAO_0000115 "Distress in response to minor changes in one's environmental expectations." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:comment "Typical examples of resistance to trivial environmental changes include distress when receiving the wrong color cup or when furniture is moved." ; rdfs:label "Resistance to trivial environmental changes" ; rdfs:subClassOf obo:HP_5200130 . obo:HP_5200053 obo:IAO_0000115 "A consistent failure to nonverbally respond to verbal cues such as a failure to shift attention or look at the source of the cue." ; dcterms:contributor , , , ; a owl:Class ; rdfs:comment "This term describes a behavioral abnormality and does not apply to those who do not respond to cues due to hearing impairment." ; rdfs:label "Lack of nonverbal response to verbal cues" ; rdfs:subClassOf obo:HP_5200036 . obo:HP_5200054 obo:IAO_0000115 "A consistent failure to verbally respond to verbal cues which are intended to elicit a verbal response." ; dcterms:contributor , , , ; a owl:Class ; rdfs:comment "This term describes a behavioral abnormality and does not apply to those who do not respond to cues due to hearing or language impairment." ; rdfs:label "Lack of verbal response to verbal cues" ; rdfs:subClassOf obo:HP_5200036 . obo:HP_5200055 obo:IAO_0000115 "Reduced use of speech-integrated gestures such as the use of beat gestures." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Reduced co-speech gestures" ; rdfs:subClassOf obo:HP_4000081, obo:HP_5200030 . obo:HP_5200056 obo:IAO_0000115 "Absence or reduction in the use of head nodding to indicate \"yes\" or head shaking to indicate \"no\"." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Limited head nodding or shaking" ; rdfs:subClassOf obo:HP_4000081 . obo:HP_5200057 obo:IAO_0000115 "Absence or reduction in the use of pointing to request or direct another's attention." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Limited pointing" ; rdfs:subClassOf obo:HP_4000081 . obo:HP_5200058 obo:IAO_0000115 "A decreased tolerance to sensory stimuli that triggers emotional and/or physical distress." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Sensory hypersensitivity" ; rdfs:subClassOf obo:HP_5200046 . obo:HP_5200059 obo:IAO_0000115 "Increased tolerance to sensory stimuli due to diminished sensory ability." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Sensory hyposensitivity unexplained by sensory deficit" ; rdfs:subClassOf obo:HP_5200046 . obo:HP_5200060 obo:IAO_0000115 "Hyperresponsive to sound that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Loudness intolerance", "Sensitivity to noise" ; a owl:Class ; rdfs:label "Auditory hypersensitivity" ; rdfs:subClassOf obo:HP_5200058 . obo:HP_5200061 obo:IAO_0000115 "A decreased tolerance to physical touch." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Tactile hypersensitivity" ; rdfs:subClassOf obo:HP_5200058 . obo:HP_5200062 obo:IAO_0000115 "Pursuit of specific sounds or noises that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Auditory sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200063 obo:IAO_0000115 "Pursuit of a particular taste that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Gustatory sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200064 obo:IAO_0000115 "Pursuit of specific scents, smells, or fragrances that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Smell seeking" ; a owl:Class ; rdfs:label "Olfactory sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200065 obo:IAO_0000115 "Pursuit of a specific texture that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Tactile sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200066 obo:IAO_0000115 "Pursuit of vestibular stimulation that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Vestibular sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200067 obo:IAO_0000115 "Pursuit visual stimulation by looking at specific sights, images, and/or colors that is abnormal in intensity and/or frequency." ; dcterms:contributor , , , , ; a owl:Class ; rdfs:label "Visual sensory seeking" ; rdfs:subClassOf obo:HP_4000079 . obo:HP_5200068 obo:IAO_0000115 "A tendency to ask questions that are overly personal or otherwise inappropriate in the social situation in which they are asked." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Socially innappropriate questioning" ; rdfs:subClassOf obo:HP_5200029 . obo:HP_5200069 obo:IAO_0000115 "An excessive frequency of spinning one's body." ; dcterms:contributor , , , , ; oboInOwl:hasExactSynonym "Twirling" ; a owl:Class ; rdfs:label "Spinning" ; rdfs:subClassOf obo:HP_5200019, obo:HP_5200066 . obo:HP_5200071 obo:IAO_0000115 "Repetition of borrowed words or phrases outside of the context in which they were originally heard. E.g., scripting from TV shows or movies." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Delayed Echolalia" ; rdfs:subClassOf obo:HP_0010529 . obo:HP_5200072 obo:IAO_0000115 "Immediate repetition of another person's speech." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Immediate Echolalia" ; rdfs:subClassOf obo:HP_0010529 . obo:HP_5200073 obo:IAO_0000115 "Excessive cleaning of surfaces, living space, or environment that is excessive for the situational context." ; dcterms:contributor , , , ; a owl:Class ; rdfs:label "Excessive cleaning" ; rdfs:subClassOf obo:HP_0000722 . obo:HP_5200100 a owl:Class ; rdfs:label "Facial expressions not directed to others" ; rdfs:subClassOf obo:HP_4000087 . obo:HP_5200101 a owl:Class ; rdfs:label "Limited Repertoire of gestures" ; rdfs:subClassOf obo:HP_4000090 . obo:HP_5200102 a owl:Class ; rdfs:label "Reduced social smiling" ; rdfs:subClassOf obo:HP_0012760, obo:HP_4000075 . obo:HP_5200103 a owl:Class ; rdfs:label "Reduced social responsiveness" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_5200104 obo:IAO_0000115 "An abnormality in a child's ability play." ; a owl:Class ; rdfs:comment "Does not apply to the presence of abnormal play. The presence of abnormal play should be specified under atypical repetitive behaviors." ; rdfs:label "Abnormal play" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_5200105 obo:IAO_0000115 "Reduced or lack of pretending in play (does not assign abstract properties to objects, use invisible objects, or use objects in nonliteral ways other than their intended purpose in play)." ; a owl:Class ; rdfs:label "Reduced imaginative play skills" ; rdfs:subClassOf obo:HP_5200104 . obo:HP_5200108 obo:IAO_0000115 "Use of objects in atypical, unimaginitive ways other than for which they are intended (banging, throwing, shaking, sorting, lining up, spinning)." ; a owl:Class ; rdfs:label "Nonfunctional or atypical use of objects in play" ; rdfs:subClassOf obo:HP_0031432 . obo:HP_5200110 a owl:Class ; rdfs:label "Preferes being alone" ; rdfs:subClassOf obo:HP_5200020 . obo:HP_5200111 a owl:Class ; rdfs:label "Avoids emotional intimacy" ; rdfs:subClassOf obo:HP_5200020, obo:HP_5200024, obo:HP_5200120 . obo:HP_5200113 a owl:Class ; rdfs:label "Offers information" ; rdfs:subClassOf obo:HP_5200027 . obo:HP_5200116 a owl:Class ; rdfs:label "Difficulty understanding nonliteral meaning of conversation" ; rdfs:subClassOf obo:HP_5200021 . obo:HP_5200117 a owl:Class ; rdfs:label "Poor recognition of injustice" ; rdfs:subClassOf obo:HP_5200021 . obo:HP_5200118 a owl:Class ; rdfs:label "Difficulty recognizing another's emotions" ; rdfs:subClassOf obo:HP_5200021, obo:HP_5200120 . obo:HP_5200119 a owl:Class ; rdfs:label "Difficulty understanding humor" ; rdfs:subClassOf obo:HP_5200021 . obo:HP_5200120 a owl:Class ; rdfs:label "Abnormality in emotional social interactions" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_5200121 a owl:Class ; rdfs:label "Treats people like objects" ; rdfs:subClassOf obo:HP_5200120 . obo:HP_5200122 a owl:Class ; rdfs:label "Difficulty communicating ones emotions" ; rdfs:subClassOf obo:HP_5200120, obo:HP_5200128 . obo:HP_5200123 a owl:Class ; rdfs:label "Abnormal response to social norms" ; rdfs:subClassOf obo:HP_0012433 . obo:HP_5200124 a owl:Class ; rdfs:label "Indifference to social norms" ; rdfs:subClassOf obo:HP_5200123 . obo:HP_5200125 a owl:Class ; rdfs:label "Aggression toward others" ; rdfs:subClassOf obo:HP_0000718 . obo:HP_5200126 a owl:Class ; rdfs:label "Aggression toward cargivers" ; rdfs:subClassOf obo:HP_5200125 . obo:HP_5200127 a owl:Class ; rdfs:label "Aggression toward non caregivers" ; rdfs:subClassOf obo:HP_5200125 . obo:HP_5200128 a owl:Class ; rdfs:label "Deficit applying language skills across context" ; rdfs:subClassOf obo:HP_0012433, obo:HP_0034434 . obo:HP_5200129 obo:IAO_0000115 "Insistence on rituals which are self-imposed on a person's environment including directing the behavior of those around them." ; a owl:Class ; rdfs:label "Abnormal rituals" ; rdfs:subClassOf obo:HP_5200130 . obo:HP_5200130 a owl:Class ; rdfs:label "Insistence on sameness" ; rdfs:subClassOf obo:HP_5200045 . obo:HP_5200131 a owl:Class ; rdfs:label "Reduced use of language for social purposes" ; rdfs:subClassOf obo:HP_5200128 . obo:HP_5200132 a owl:Class ; rdfs:label "Atypical sensory examination of objects" ; rdfs:subClassOf obo:HP_4000079, obo:HP_5200108 . obo:HP_5200133 a owl:Class ; rdfs:label "Intense attachment to unusual objects" ; rdfs:subClassOf obo:HP_5200108 . obo:HP_5200134 obo:IAO_0000115 "An excessive frequency of jumping in place." ; oboInOwl:hasExactSynonym "Bouncing", "Hopping", "Pogo-ing" ; a owl:Class ; rdfs:label "Jumping" ; rdfs:subClassOf obo:HP_5200019, obo:HP_5200066 . obo:HP_5200135 a owl:Class ; rdfs:label "Delay in the acquisition of play skills" ; rdfs:subClassOf obo:HP_0012434 . obo:HP_5200136 a owl:Class ; rdfs:label "Reduced social reciprocity with peers" ; rdfs:subClassOf obo:HP_0012760 . obo:HP_5200137 a owl:Class ; rdfs:label "Reduced attempt to get or direct attention of peers" ; rdfs:subClassOf obo:HP_5200136 . obo:HP_5201000 obo:IAO_0000115 "Unilateral cleft lip cleft that starts from the bottom of the upper lip but does not reach the nasal cavity." ; dcterms:creator ; a owl:Class ; rdfs:comment "Please use this term only when the cleft lip is unilateral, ie occuring only on one side." ; rdfs:label "Incomplete unilateral cleft lip" ; rdfs:subClassOf obo:HP_0011340, obo:HP_0100333 . obo:HP_5201001 obo:IAO_0000115 "Unilateral cleft lip cleft that starts from the bottom of the upper lip and reaches the nasal cavity." ; dcterms:creator ; a owl:Class ; rdfs:comment "Please use this term only when the cleft lip is unilateral, ie occuring only on one side." ; rdfs:label "Complete unilateral cleft lip" ; rdfs:subClassOf obo:HP_0100333, obo:HP_5201009 . obo:HP_5201002 obo:IAO_0000115 "Notch, groove, or scar of the upper lip without noticeable rupture of the lip. Microforms are sometimes associated with disruption of the continuity of the orbicularis oris muscle." ; dcterms:creator ; a owl:Class ; rdfs:comment "Please use this term only when the cleft lip is unilateral, ie occuring only on one side." ; rdfs:label "Microform unilateral cleft lip" ; rdfs:subClassOf obo:HP_0100333, obo:HP_5201010 . obo:HP_5201003 obo:IAO_0000115 "Cleft hard palate in which the cleft goes through the entire length of the hard palate." ; dcterms:creator ; a owl:Class ; rdfs:label "Complete cleft hard palate" ; rdfs:subClassOf obo:HP_0410005 . obo:HP_5201004 obo:IAO_0000115 "Cleft hard palate in which the cleft doe not goes through the entire length of the hard palate." ; dcterms:creator ; a owl:Class ; rdfs:label "Incomplete cleft hard palate" ; rdfs:subClassOf obo:HP_0410005 . obo:HP_5201005 obo:IAO_0000115 "Cleft soft palate in which the cleft goes through the entire length of the soft palate." ; dcterms:creator ; a owl:Class ; rdfs:label "Complete cleft soft palate" ; rdfs:subClassOf obo:HP_0000185 . obo:HP_5201006 obo:IAO_0000115 "Cleft soft palate in which the cleft doe not goes through the entire length of the soft palate." ; dcterms:creator ; a owl:Class ; rdfs:label "Incomplete cleft soft palate" ; rdfs:subClassOf obo:HP_0000185 . obo:HP_5201007 obo:IAO_0000115 "Cleft maxillary alveolar ridge in which the cleft does not go through the entire length of the maxillary alveolar ridge." ; dcterms:creator ; a owl:Class ; rdfs:label "Incomplete cleft maxillary alveolar ridge" ; rdfs:subClassOf obo:HP_0010289 . obo:HP_5201008 obo:IAO_0000115 "Cleft maxillary alveolar ridge in which the cleft goes through the entire length of the maxillary alveolar ridge." ; dcterms:creator ; a owl:Class ; rdfs:label "Complete cleft maxillary alveolar ridge" ; rdfs:subClassOf obo:HP_0010289 . obo:HP_5201009 obo:IAO_0000115 "Cleft of the upper lip that starts from the bottom of the upper lip and reaches the nasal cavity." ; dcterms:creator ; a owl:Class ; rdfs:comment "If the cleft lip is on only one side, use 'Complete unilateral cleft lip' (HP:5201001)" ; rdfs:label "Complete cleft of the upper lip" ; rdfs:subClassOf obo:HP_0000204 . obo:HP_5201010 obo:IAO_0000115 "Notch, groove, or scar of the upper lip without noticeable rupture of the lip." ; dcterms:creator ; a owl:Class ; rdfs:comment "If the cleft lip is on only one side, use 'Microform unilateral cleft lip' (HP:5201002)." ; rdfs:label "Microform cleft of the upper lip" ; rdfs:subClassOf obo:HP_0000204 . obo:HP_5201011 obo:IAO_0000115 "Bilateral cleft lip in which the cleft lip on both sides is complete, i.e. start from the bottom of the upper lip and reach the nasal cavity." ; dcterms:creator ; a owl:Class ; rdfs:label "Complete bilateral cleft lip" ; rdfs:subClassOf obo:HP_0100336 . obo:HP_5201012 obo:IAO_0000115 "Bilateral cleft lip in which the cleft lip on both sides are incomplete (i.e. start from the bottom of the upper lip but do not reach the nasal cavity), or the cleft lip on one is incomplete and a microform on the other side." ; dcterms:creator ; a owl:Class ; rdfs:label "Incomplete bilateral cleft lip" ; rdfs:subClassOf obo:HP_0100336 . obo:HP_5201013 obo:IAO_0000115 "Bilateral cleft lip in which the cleft lip on both sides are microform, i.e. a notch, groove, or scar without noticeable rupture of the lip." ; dcterms:creator ; a owl:Class ; rdfs:label "Microform bilateral cleft lip" ; rdfs:subClassOf obo:HP_0100336 . obo:HP_5201014 obo:IAO_0000115 "Bilateral cleft lip in which the cleft lip on one side is complete (i.e. starts from the bottom of the upper lip and reaches the nasal cavity), and the one on the other side is incomplete (i.e. starts from the bottom of the upper lip but does not reach the nasal cavity) or microform (i.e. a notch, groove, or scar without noticeable rupture of the lip)." ; dcterms:creator ; a owl:Class ; rdfs:comment "Consider making additional annotations to specify the type of cleft lip on each side using 'Complete cleft of the upper lip' (HP:5201009), 'Incomplete cleft of the upper lip' (HP:0011340), and/or 'Microform cleft of the upper lip' (HP:5201010)." ; rdfs:label "Asymmetric bilateral cleft lip" ; rdfs:subClassOf obo:HP_0100336 . obo:HsapDv_0000000 obo:IAO_0000115 "A spatiotemporal region encompassing some part of the life cycle of an organism." ; oboInOwl:hasDbXref "UBERON:0000105" ; oboInOwl:hasExactSynonym "developmental stage" ; oboInOwl:hasNarrowSynonym "stage" ; oboInOwl:hasOBONamespace "human_stages_ontology" ; oboInOwl:id "HsapDv:0000000" ; a owl:Class ; rdfs:label "human life cycle stage" . obo:HsapDv_0000001 obo:IAO_0000115 "Temporal interval that defines human life from the prenatal stage until late adulthood." ; hsapdv:start_dpf "0.0"^^xsd:float ; oboInOwl:hasDbXref "UBERON:0000104" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000001" ; a owl:Class ; rdfs:label "human life cycle" ; rdfs:subClassOf obo:HsapDv_0000000 . obo:HsapDv_0000002 obo:IAO_0000115 "Prenatal stage that starts with fertilization and ends with a fully formed embryo, before undergoing last development during the fetal stage." ; hsapdv:end_dpf "56.0"^^xsd:float ; hsapdv:start_dpf "0.0"^^xsd:float ; oboInOwl:hasDbXref "EV:0300001", "FMA:72652" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "embryo stage", "first trimester" ; oboInOwl:id "HsapDv:0000002" ; a owl:Class ; rdfs:comment "By embryo we mean in the sense of up to the 8th week postfertilization (over 7 and under 8 weeks), we treat fetus as a separate stage." ; rdfs:label "embryonic human stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000045 ] . obo:HsapDv_0000037 obo:IAO_0000115 "Prenatal stage that starts with the fully formed embryo and ends at birth." ; hsapdv:end_dpf "266.0"^^xsd:float ; hsapdv:start_dpf "56.0"^^xsd:float ; oboInOwl:hasDbXref "EV:0300011", "UBERON:0007220" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "fetus stage", "foetus stage", "second and third trimester" ; oboInOwl:id "HsapDv:0000037" ; a owl:Class ; rdfs:comment "Prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus. The use of the term \"fetus\" generally implies that a mammalian embryo has developed to the point of being recognizable as belonging to its own species, though the point at which this occurs is subjective. [Wikipedia:Fetus]" ; rdfs:label "fetal stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000045 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:HsapDv_0000002 ] . obo:HsapDv_0000045 obo:IAO_0000115 "Prenatal stage that starts with fertilization and ends at birth." ; hsapdv:end_dpf "266.0"^^xsd:float ; hsapdv:end_ypb "0.0"^^xsd:float ; hsapdv:start_dpf "0.0"^^xsd:float ; oboInOwl:hasDbXref "UBERON:0000068" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000045" ; a owl:Class ; rdfs:label "prenatal stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000001 ] . obo:HsapDv_0000080 obo:IAO_0000115 "Human developmental stage that covers the period from birth until 12 years old." ; hsapdv:end_ypb "13.0"^^xsd:float ; hsapdv:start_ypb "0.0"^^xsd:float ; oboInOwl:hasDbXref "UBERON:0000112" ; oboInOwl:hasExactSynonym "0-12 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "child" ; oboInOwl:id "HsapDv:0000080" ; a owl:Class ; rdfs:label "immature stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000001 ] . obo:HsapDv_0000081 obo:IAO_0000115 "Immature stage that refers to child who is over 2 and under 13 years old." ; hsapdv:end_ypb "13.0"^^xsd:float ; hsapdv:start_ypb "2.0"^^xsd:float ; oboInOwl:hasExactSynonym "2-12 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000081" ; a owl:Class ; rdfs:label "child stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000080 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:HsapDv_0000083 ] . obo:HsapDv_0000082 obo:IAO_0000115 "Immature stage that refers to a newborn who is under 32 days old." ; hsapdv:end_mpb "1.0"^^xsd:float ; hsapdv:end_ypb "0.083"^^xsd:float ; hsapdv:start_mpb "0.0"^^xsd:float ; hsapdv:start_ypb "0.0"^^xsd:float ; oboInOwl:hasExactSynonym "0-1 month" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "neonatal stage", "neonate" ; oboInOwl:id "HsapDv:0000082" ; a owl:Class ; rdfs:label "newborn human stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000080 ] . obo:HsapDv_0000083 obo:IAO_0000115 "Immature stage that refers to an infant who is over 31 days and is under 24 months old." ; hsapdv:end_mpb "24.0"^^xsd:float ; hsapdv:end_ypb "2.0"^^xsd:float ; hsapdv:start_mpb "1.0"^^xsd:float ; hsapdv:start_ypb "0.083"^^xsd:float ; oboInOwl:hasExactSynonym "1-23 months", "infantile stage" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000083" ; a owl:Class ; rdfs:label "infant stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000080 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:HsapDv_0000082 ] . obo:HsapDv_0000086 obo:IAO_0000115 "Mature stage that refers to an adolescent who is over 13 and under 19 years old." ; hsapdv:end_ypb "19.0"^^xsd:float ; hsapdv:start_ypb "13.0"^^xsd:float ; oboInOwl:hasExactSynonym "13-18 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "teen", "teenager" ; oboInOwl:id "HsapDv:0000086" ; a owl:Class ; rdfs:label "adolescent stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000204 ] . obo:HsapDv_0000087 obo:IAO_0000115 "Human developmental stage that refers to an adult who is over 19." ; hsapdv:start_ypb "19.0"^^xsd:float ; oboInOwl:hasExactSynonym "19+ years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000087" ; a owl:Class ; rdfs:label "human adult stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000204 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:HsapDv_0000086 ] . obo:HsapDv_0000088 obo:IAO_0000115 "Adult stage that refers to an adult who is under 45." ; hsapdv:end_ypb "45.0"^^xsd:float ; hsapdv:start_ypb "19.0"^^xsd:float ; oboInOwl:hasExactSynonym "19-44 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000088" ; a owl:Class ; rdfs:label "human early adulthood stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000087 ] . obo:HsapDv_0000089 obo:IAO_0000115 "Early adulthood that refers to an adult who is under 25." ; hsapdv:end_ypb "25.0"^^xsd:float ; hsapdv:start_ypb "19.0"^^xsd:float ; oboInOwl:hasExactSynonym "19-24 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000089" ; a owl:Class ; rdfs:label "young adult stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000088 ] . obo:HsapDv_0000091 obo:IAO_0000115 "Adult stage that refers to an adult who is over 45." ; hsapdv:start_ypb "45.0"^^xsd:float ; oboInOwl:hasExactSynonym "45+ years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:hasRelatedSynonym "Middle Aged + Aged" ; oboInOwl:id "HsapDv:0000091" ; a owl:Class ; rdfs:label "human late adulthood stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000087 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:HsapDv_0000088 ] . obo:HsapDv_0000092 obo:IAO_0000115 "Late adulthood that refers to an adult who is over 45 and under 65." ; hsapdv:end_ypb "65.0"^^xsd:float ; hsapdv:start_ypb "45.0"^^xsd:float ; oboInOwl:hasExactSynonym "45-64 years" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000092" ; a owl:Class ; rdfs:label "human middle aged stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000091 ] . obo:HsapDv_0000204 obo:IAO_0000115 "Human developmental stage that refers to a sexually mature human." ; hsapdv:start_ypb "13.0"^^xsd:float ; oboInOwl:hasDbXref "UBERON:0000113" ; oboInOwl:hasOBONamespace "human_developmental_stage" ; oboInOwl:id "HsapDv:0000204" ; a owl:Class ; rdfs:label "mature stage" ; rdfs:subClassOf obo:HsapDv_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:HsapDv_0000001 ] . obo:IAO_0000111 a owl:AnnotationProperty . obo:IAO_0000112 a owl:AnnotationProperty . obo:IAO_0000114 a owl:AnnotationProperty . obo:IAO_0000115 a owl:AnnotationProperty ; rdfs:label "definition" . obo:IAO_0000116 oboInOwl:hasDbXref "IAO:0000116" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "editor_note" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "editor_note" ; a owl:AnnotationProperty ; rdfs:label "editor note" . obo:IAO_0000117 a owl:AnnotationProperty . obo:IAO_0000118 a owl:AnnotationProperty . obo:IAO_0000119 a owl:AnnotationProperty . obo:IAO_0000231 a owl:AnnotationProperty . obo:IAO_0000232 a owl:AnnotationProperty . obo:IAO_0000233 a owl:AnnotationProperty . obo:IAO_0000424 a owl:AnnotationProperty . obo:IAO_0000589 a owl:AnnotationProperty . obo:IAO_0000600 a owl:AnnotationProperty . obo:IAO_0000700 oboInOwl:hasDbXref "IAO:0000700" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_ontology_root_term" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "has_ontology_root_term" ; a owl:AnnotationProperty ; rdfs:label "has ontology root term", "preferred_root" . obo:IAO_0006012 a owl:AnnotationProperty . obo:IAO_0100001 a owl:AnnotationProperty ; rdfs:label "term replaced by" . obo:MPATH_0 obo:IAO_0000115 "Pathological structure or process" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:0" ; a owl:Class ; rdfs:label "pathological entity" ; rdfs:subClassOf obo:MPATH_1000 . obo:MPATH_1 obo:IAO_0000115 "The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:1" ; a owl:Class ; rdfs:label "cell and tissue damage" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_1000 obo:IAO_0000115 "Phenotypic observation of the presence or absence of a pathological entity." ; oboInOwl:created_by "Luke Slater" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:1000" ; a owl:Class ; rdfs:label "pathological phenotype observation" . obo:MPATH_105 obo:IAO_0000115 "Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:105" ; a owl:Class ; rdfs:label "circulatory disorder" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_119 obo:IAO_0000115 "Abnormal release of whole blood or the cellular component from the circulation." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:119" ; a owl:Class ; rdfs:label "hemorrhage and non-specified extravasation" ; rdfs:subClassOf obo:MPATH_105 . obo:MPATH_120 obo:IAO_0000115 "A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:120" ; a owl:Class ; rdfs:comment "May also be used for any organ, although more generally used with respect to the skin." ; rdfs:label "ecchymosis" ; rdfs:subClassOf obo:MPATH_119 . obo:MPATH_124 obo:IAO_0000115 "An area of necrosis resulting from a sudden cessation of arterial or venous blood supply." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:124" ; a owl:Class ; rdfs:label "infarct" ; rdfs:subClassOf obo:MPATH_105 . obo:MPATH_126 obo:IAO_0000115 "Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:126" ; a owl:Class ; rdfs:label "growth and differentiation defect" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_14 obo:IAO_0000115 "A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:14" ; a owl:Class ; rdfs:label "process of degenerative change" ; rdfs:subClassOf obo:MPATH_597 . obo:MPATH_149 obo:IAO_0000115 "Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia)." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "epidermal hyperplasia.", "squamous cell hyperplasia" ; oboInOwl:id "MPATH:149" ; a owl:Class ; rdfs:label "squamous hyperplasia" ; rdfs:subClassOf obo:MPATH_602 . obo:MPATH_154 obo:IAO_0000115 "Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "cornification", "hyperorthokeratosis", "hyperparakeratosis" ; oboInOwl:id "MPATH:154" ; a owl:Class ; rdfs:label "hyperkeratosis" ; rdfs:subClassOf obo:MPATH_149 . obo:MPATH_156 obo:IAO_0000115 "Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:156" ; a owl:Class ; rdfs:label "parakeratosis" ; rdfs:subClassOf obo:MPATH_154 . obo:MPATH_175 obo:IAO_0000115 "The process, normal or abnormal, of damage repair or wound closure." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:175" ; a owl:Class ; rdfs:label "healing and repair process" ; rdfs:subClassOf obo:MPATH_596 . obo:MPATH_176 obo:IAO_0000115 "Replacement of connective tissue by fibro-fatty deposits and scar tissue." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:176" ; a owl:Class ; rdfs:label "connective tissue replacement" ; rdfs:subClassOf obo:MPATH_175 . obo:MPATH_184 obo:IAO_0000115 "Any pathological thickening or hardening of a tissue." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "Induration" ; oboInOwl:id "MPATH:184" ; a owl:Class ; rdfs:label "sclerosis" ; rdfs:subClassOf obo:MPATH_176 . obo:MPATH_188 obo:IAO_0000115 "Inappropriate or aberrant activation or suppression of the immune or inflammatory response." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:188" ; a owl:Class ; rdfs:label "immunopathological process" ; rdfs:subClassOf obo:MPATH_596 . obo:MPATH_194 obo:IAO_0000115 "Tissue response to inappropriate immune/inflammatory process." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:194" ; a owl:Class ; rdfs:label "immune mediated disease" ; rdfs:subClassOf obo:MPATH_188 . obo:MPATH_196 obo:IAO_0000115 "Inflammation of the skin." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:196" ; a owl:Class ; rdfs:label "dermatitis" ; rdfs:subClassOf obo:MPATH_212 . obo:MPATH_197 obo:IAO_0000115 "Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:197" ; a owl:Class ; rdfs:label "glomerulonephritis" ; rdfs:subClassOf obo:MPATH_212 . obo:MPATH_198 obo:IAO_0000115 "An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:198" ; a owl:Class ; rdfs:label "immune mediated hemolytic anaemia" ; rdfs:subClassOf obo:MPATH_212 . obo:MPATH_201 obo:IAO_0000115 "Inflammation of a blood vessel." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "angiitis", "arteritis", "lymphangiitis", "phlebitis" ; oboInOwl:id "MPATH:201" ; a owl:Class ; rdfs:label "vasculitis" ; rdfs:subClassOf obo:MPATH_212 . obo:MPATH_212 obo:IAO_0000115 "A tissue reaction to an internal or external injury." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:212" ; a owl:Class ; rdfs:label "inflammation" ; rdfs:subClassOf obo:MPATH_194 . obo:MPATH_218 obo:IAO_0000115 "A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:218" ; a owl:Class ; rdfs:label "neoplasm" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_25 obo:IAO_0000115 "Degenerative process characteristic of a particular tissue." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:25" ; a owl:Class ; rdfs:label "tissue specific degenerative process" ; rdfs:subClassOf obo:MPATH_14 . obo:MPATH_254 obo:IAO_0000115 "Tumors showing multiple histological componants/differentiation." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:254" ; a owl:Class ; rdfs:label "complex tumor" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_267 obo:IAO_0000115 "Neoplasms derived from glandular epithelial cells." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:267" ; a owl:Class ; rdfs:label "glandular tumor" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_27 obo:IAO_0000115 "Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "Degenerative joint disease", "osteoarthrosis" ; oboInOwl:id "MPATH:27" ; a owl:Class ; rdfs:label "arthrosis" ; rdfs:subClassOf obo:MPATH_25 . obo:MPATH_270 obo:IAO_0000115 "A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:270" ; a owl:Class ; rdfs:label "adenoma" ; rdfs:subClassOf obo:MPATH_267, obo:MPATH_556 . obo:MPATH_28 obo:IAO_0000115 "Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:28" ; a owl:Class ; rdfs:comment "Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima." ; rdfs:label "atherosclerosis" ; rdfs:subClassOf obo:MPATH_25 . obo:MPATH_287 obo:IAO_0000115 "Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0)." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "Adenoma, endocrine pancreas", "adenomatosis", "islet (pancreatic) cell tumor benign" ; oboInOwl:id "MPATH:287" ; a owl:Class ; rdfs:label "islet cell adenoma" ; rdfs:subClassOf obo:MPATH_270 . obo:MPATH_309 obo:IAO_0000115 "Germ cell and non-germ cell tumors of the testis and ovary." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:309" ; a owl:Class ; rdfs:label "gonadal tumor" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_31 obo:IAO_0000115 "Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:31" ; a owl:Class ; rdfs:label "emphysema" ; rdfs:subClassOf obo:MPATH_25 . obo:MPATH_310 obo:IAO_0000115 "Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:310" ; a owl:Class ; rdfs:label "germ cell tumor" ; rdfs:subClassOf obo:MPATH_309 . obo:MPATH_322 obo:IAO_0000115 "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1)." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:322" ; a owl:Class ; rdfs:label "teratoma" ; rdfs:subClassOf obo:MPATH_254, obo:MPATH_310 . obo:MPATH_33 obo:IAO_0000115 "Accumulation of substances within, on the surface of or between cells." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:33" ; a owl:Class ; rdfs:label "intracellular and extracellular accumulation" ; rdfs:subClassOf obo:MPATH_1 . obo:MPATH_335 obo:IAO_0000115 "Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:335" ; a owl:Class ; rdfs:label "hematopoietic/lymphoid malignancies/disorder" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_34 obo:IAO_0000115 "Extracellular deposition of amyloid protein." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "Amyloidosis" ; oboInOwl:id "MPATH:34" ; a owl:Class ; rdfs:comment "Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope." ; rdfs:label "amyloid deposition" ; rdfs:subClassOf obo:MPATH_33 . obo:MPATH_342 obo:IAO_0000115 "Leukaemias of the myeloid lineage." ; oboInOwl:hasDbXref "URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "granulocytic leukaemia" ; oboInOwl:id "MPATH:342" ; a owl:Class ; rdfs:label "myeloid leukaemia" ; rdfs:subClassOf obo:MPATH_496 . obo:MPATH_346 oboInOwl:created_by "George Gkoutos" ; oboInOwl:creation_date "2011-03-22T01:12:01Z" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:346" ; a owl:Class ; rdfs:label "autoimmune mediated disease" ; rdfs:subClassOf obo:MPATH_194 . obo:MPATH_36 obo:IAO_0000115 "Intra or extracellular deposition of calcium usually as calcium phosphate." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:36" ; a owl:Class ; rdfs:label "calcium deposition" ; rdfs:subClassOf obo:MPATH_555 . obo:MPATH_379 obo:IAO_0000115 "Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) ." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:379" ; a owl:Class ; rdfs:label "odontogenic tumor" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_387 obo:IAO_0000115 "Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0)." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:387" ; a owl:Class ; rdfs:label "odontoma" ; rdfs:subClassOf obo:MPATH_254, obo:MPATH_379, obo:MPATH_74 . obo:MPATH_404 obo:IAO_0000115 "Neoplasms of the soft and connective tissues." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:404" ; a owl:Class ; rdfs:label "soft tissue tumor" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_429 obo:IAO_0000115 "Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:429" ; a owl:Class ; rdfs:label "myxomatous tumor" ; rdfs:subClassOf obo:MPATH_404 . obo:MPATH_474 obo:IAO_0000115 "Dilation of a tubular structure." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:474" ; a owl:Class ; rdfs:comment "Often associated with an obstruction." ; rdfs:label "ectasia" ; rdfs:subClassOf obo:MPATH_66 . obo:MPATH_476 obo:IAO_0000115 "A lesion formed by a dilated capillary or terminal artery." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:476" ; a owl:Class ; rdfs:label "telangiectasia" ; rdfs:subClassOf obo:MPATH_474 . obo:MPATH_496 obo:IAO_0000115 "Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition." ; oboInOwl:hasDbXref "URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:496" ; a owl:Class ; rdfs:label "Non-Lymphoid leukaemias" ; rdfs:subClassOf obo:MPATH_515 . obo:MPATH_502 obo:IAO_0000115 "Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts." ; oboInOwl:hasDbXref "URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:502" ; a owl:Class ; rdfs:label "monocytic leukaemia" ; rdfs:subClassOf obo:MPATH_342 . obo:MPATH_515 obo:IAO_0000115 "Hematological neoplasias of non-lymphoid origin." ; oboInOwl:hasDbXref "URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:515" ; a owl:Class ; rdfs:label "non-Lymphoid neoplasias" ; rdfs:subClassOf obo:MPATH_335 . obo:MPATH_55 obo:IAO_0000115 "Developmental and structural abnormalities occurring during embryonic development or during adult life." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:55" ; a owl:Class ; rdfs:label "developmental and structural abnormality" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_555 obo:IAO_0000115 "Deposition of any homogeneous inorganic material." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:555" ; a owl:Class ; rdfs:label "mineralisation" ; rdfs:subClassOf obo:MPATH_33 . obo:MPATH_556 obo:IAO_0000115 "Lesions which in some cases have the potential to become progressively growing malignant tumors." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:556" ; a owl:Class ; rdfs:label "potentially cancerous lesions" ; rdfs:subClassOf obo:MPATH_218 . obo:MPATH_56 obo:IAO_0000115 "Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:56" ; a owl:Class ; rdfs:label "developmental or adult structural defect" ; rdfs:subClassOf obo:MPATH_55 . obo:MPATH_574 obo:IAO_0000115 "Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:574" ; a owl:Class ; rdfs:label "nephroblastomatosis" ; rdfs:subClassOf obo:MPATH_64 . obo:MPATH_579 obo:IAO_0000115 "Loss of epithelium and the basement membrane (full thickness). Cf Erosion." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:579" ; a owl:Class ; rdfs:label "ulcer" ; rdfs:subClassOf obo:MPATH_1 . obo:MPATH_596 obo:IAO_0000115 "The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:596" ; a owl:Class ; rdfs:label "pathological process" ; rdfs:subClassOf obo:MPATH_0 . obo:MPATH_597 obo:IAO_0000115 "Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:597" ; a owl:Class ; rdfs:label "cell and tissue damage process" ; rdfs:subClassOf obo:MPATH_596 . obo:MPATH_599 obo:IAO_0000115 "developmental process abnormalities" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:599" ; a owl:Class ; rdfs:label "developmental process abnormalities" ; rdfs:subClassOf obo:MPATH_596 . obo:MPATH_602 obo:IAO_0000115 "An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:602" ; a owl:Class ; rdfs:label "hyperplastic tissue" ; rdfs:subClassOf obo:MPATH_126 . obo:MPATH_603 obo:IAO_0000115 "Anatomically located instance of pathological response or entity." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:603" ; a owl:Class ; rdfs:label "pathological anatomical entity" ; rdfs:subClassOf obo:MPATH_0 . obo:MPATH_607 obo:IAO_0000115 "Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:607" ; a owl:Class ; rdfs:label "healing and repair structure" ; rdfs:subClassOf obo:MPATH_603 . obo:MPATH_608 obo:IAO_0000115 "A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:608" ; a owl:Class ; rdfs:comment "Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material." ; rdfs:label "abscess" ; rdfs:subClassOf obo:MPATH_607 . obo:MPATH_62 obo:IAO_0000115 "Formation of an epithelium bounded cavity not associated with neoplasia." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:62" ; a owl:Class ; rdfs:label "cyst" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_622 obo:IAO_0000115 "Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells." ; oboInOwl:hasExactSynonym "lipidosis" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "adipose degeneration", "fatty change", "fatty degeneration" ; oboInOwl:id "MPATH:622" ; a owl:Class ; rdfs:comment "Most commonly associated with degenerative change in the liver." ; rdfs:label "steatosis" ; rdfs:subClassOf obo:MPATH_33 . obo:MPATH_64 obo:IAO_0000115 "Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:64" ; a owl:Class ; rdfs:comment "The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term." ; rdfs:label "developmental dysplasia" ; rdfs:subClassOf obo:MPATH_599 . obo:MPATH_66 obo:IAO_0000115 "Increase in the diameter of an orifice or tubular structure beyond its normal dimensions." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:66" ; a owl:Class ; rdfs:label "dilatation" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_675 oboInOwl:created_by "George Gkoutos" ; oboInOwl:creation_date "2011-02-19T04:09:12Z" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:675" ; a owl:Class ; rdfs:label "psoriasiform dermatitis" ; rdfs:subClassOf obo:MPATH_196 . obo:MPATH_68 obo:IAO_0000115 "A blind ended outpouching through the wall of a tubular organ or bounded cavity." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:68" ; a owl:Class ; rdfs:label "diverticulum" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_70 obo:IAO_0000115 "An abnormal passage between two internal organs or leading from a cavity to the body surface." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:70" ; a owl:Class ; rdfs:label "fistula" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_718 obo:IAO_0000115 "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine." ; oboInOwl:created_by "Paul" ; oboInOwl:creation_date "2011-06-06T03:39:01Z" ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:718" ; a owl:Class ; rdfs:label "pre-sacral teratoma" ; rdfs:subClassOf obo:MPATH_322 . obo:MPATH_74 obo:IAO_0000115 "A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:74" ; a owl:Class ; rdfs:label "hamartoma" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_86 obo:IAO_0000115 "Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:86" ; a owl:Class ; rdfs:label "organ specific developmental defect" ; rdfs:subClassOf obo:MPATH_55 . obo:MPATH_89 obo:IAO_0000115 "Abnormal development of the heart or vascular tissue resulting in morphological abnormality." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:89" ; a owl:Class ; rdfs:label "cardiovascular developmental defect" ; rdfs:subClassOf obo:MPATH_86 . obo:MPATH_90 obo:IAO_0000115 "Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:id "MPATH:90" ; a owl:Class ; rdfs:label "aneurysm" ; rdfs:subClassOf obo:MPATH_56 . obo:MPATH_98 obo:IAO_0000115 "A stretching and widening of the lymphatic vessels." ; oboInOwl:hasOBONamespace "mouse_pathology.ontology" ; oboInOwl:hasRelatedSynonym "Lymphectasia", "telangiectasia lymphatica" ; oboInOwl:id "MPATH:98" ; a owl:Class ; rdfs:label "lymphangiectasis" ; rdfs:subClassOf obo:MPATH_474, obo:MPATH_89 . obo:NBO_0000001 obo:IAO_0000115 "A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]" ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "stationary movement" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "body part movement" ; rdfs:subClassOf obo:NBO_0000338 . obo:NBO_0000003 obo:IAO_0000115 "Behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "affective behaviour", "mood" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "emotional behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000006 obo:IAO_0000115 "Behavior related to the acquisition and processing of information and/or the storage and retrieval of this information over time." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "learning and/or memory behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0007611" ; a owl:Class ; rdfs:label "learning and/or memory behavior" ; rdfs:subClassOf obo:NBO_0000607 . obo:NBO_0000007 obo:IAO_0000115 "The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]" ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasNarrowSynonym "mouth part movement", "other moved mouth parts" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "mouth movement" ; rdfs:subClassOf obo:NBO_0000001 . obo:NBO_0000008 dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0007622" ; a owl:Class ; rdfs:label "rhythmic behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000009 obo:IAO_0000115 "Observable characteristic of behavior associated with the specific movement from place to place of an organism." ; dc:date "2011-04-14T12:58:40Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "pathological locomotory behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "locomotory behavior phenotype" ; rdfs:subClassOf obo:NBO_0000644 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0007626 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000010 obo:IAO_0000115 "Behavior directly related to the production of offspring [NBO:AC]" ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "reproduction"@en, "reproductive behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0019098" ; a owl:Class ; rdfs:label "reproductive behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000011 obo:IAO_0000115 "\"A behavior that occurs predominantly or only, in individuals that are part of a group.\" [Wikipedia:Social_behavior]" ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "social behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0035176" ; a owl:Class ; rdfs:label "social behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000015 obo:IAO_0000115 "A behavioral interaction between organisms in which one organism has the intention of inflicting damage on another individual using physical or verbal means." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "aggression", "aggressive behaviour", "agonism" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0002118" ; a owl:Class ; rdfs:label "aggressive behavior" ; rdfs:subClassOf obo:NBO_0000003 . obo:NBO_0000018 obo:IAO_0000115 "Emotional behavior related to fear or anxiety." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "fear/anxiety related behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "fear/anxiety related behavior" ; rdfs:subClassOf obo:NBO_0000003, obo:NBO_0000469 . obo:NBO_0000024 obo:IAO_0000115 "Behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0030431" ; a owl:Class ; rdfs:label "sleeping behavior" ; rdfs:subClassOf obo:GO_0030431, obo:NBO_0000008 . obo:NBO_0000030 obo:IAO_0000115 "A kinesthetic behavior which relatively increased." ; dc:date "2011-04-14T01:09:28Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000752", "MP:0001399" ; a owl:Class ; rdfs:label "hyperactivity" ; rdfs:subClassOf obo:NBO_0000644 . obo:NBO_0000032 obo:IAO_0000115 "\"Loss of power of voluntary movement in a muscle through injury or disease of its nerve supply.\" [JAX:]" ; dc:date "2011-04-14T01:18:37Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0003470", "MP:0000753" ; a owl:Class ; rdfs:label "paralysis" ; rdfs:subClassOf obo:NBO_0000009 . obo:NBO_0000034 obo:IAO_0000115 "Behaviour related to the activity which primary purpose is the sexual reproduction." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:hasRelatedSynonym "sexual actions" ; a owl:Class ; rdfs:label "sexual activity" ; rdfs:subClassOf obo:NBO_0000010 . obo:NBO_0000043 obo:IAO_0000115 "A behavior that occurs between two individuals, such as parent and child, and involves an emotional attachment that implies a special and focused relationship." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "forming of peer relationship" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "bonding behavior" ; rdfs:subClassOf obo:NBO_0000280 . obo:NBO_0000054 obo:IAO_0000115 "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." ; dc:date "2011-04-14T01:03:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000046" ; oboInOwl:hasExactSynonym "nursing behaviour", "suckling behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0001967" ; a owl:Class ; rdfs:label "suckling behavior" ; rdfs:subClassOf obo:NBO_0000079 . obo:NBO_0000063 obo:IAO_0000115 "A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of food." ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "eating behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0042755" ; a owl:Class ; rdfs:label "regulation of eating behavior" ; rdfs:subClassOf obo:NBO_0002436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0000134 ] . obo:NBO_0000064 obo:IAO_0000115 "A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of liquids." ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "drinking behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0042756" ; a owl:Class ; rdfs:label "regulation of drinking behavior" ; rdfs:subClassOf obo:NBO_0002436 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0000130 ] . obo:NBO_0000073 obo:IAO_0000115 "The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]" ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "chew"@en, "gnaw"@en, "mastication" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "chewing" ; rdfs:subClassOf obo:NBO_0000747 . obo:NBO_0000075 obo:IAO_0000115 "A very broad category including the partial or complete performance of adult functional behaviors in non-functional contexts, as well as interactive behaviors peculiar to immature animals [NBO:AC]" ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "play"@en ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "playing behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000079 obo:IAO_0000115 "The act of bringing an object or substance into the body by swallowing, surrounding or absorbing it [NBO:SMAC]" ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "feeding behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0007631" ; a owl:Class ; rdfs:label "feeding behavior" ; rdfs:subClassOf obo:NBO_0001845 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0001845 [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:CHEBI_33290 ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001548 ] ) ] ) ] . obo:NBO_0000085 obo:IAO_0000115 "Emotional behavior related to a state of low mood and aversion to activity." ; dc:date "2011-04-14T01:20:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "depression related behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "depression behavior" ; rdfs:subClassOf obo:NBO_0000003 . obo:NBO_0000092 obo:IAO_0000115 "An emotional behavior related to a feeling of uneasiness or nervousness triggered by an identifiable triggering stimulus." ; dc:date "2011-03-31T10:01:25Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "anxiety-related behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "anxiety-related behavior" ; rdfs:subClassOf obo:NBO_0000018 . obo:NBO_0000096 obo:IAO_0000115 "A phobia characterised by fear of open spaces." ; dc:date "2011-03-31T10:18:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000756" ; a owl:Class ; rdfs:label "agoraphobia behavior" ; rdfs:subClassOf obo:NBO_0000246 . obo:NBO_0000119 obo:IAO_0000115 "A behavior that occur quickly without control, planning, or consideration of the consequences of that behavior." ; dc:date "2011-03-31T11:08:55Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "impulsive behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000120 obo:IAO_0000115 "An aggressive behavior that aims to inflicting damage on another entity using physical means." ; dc:date "2011-03-31T11:14:04Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "physical aggression behaviour", "violent behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "physical aggression behavior" ; rdfs:subClassOf obo:NBO_0000741 . obo:NBO_0000121 dc:date "2011-03-31T11:42:15Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "agonism"@en ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "agonistic behavior" ; rdfs:subClassOf obo:NBO_0000003, obo:NBO_0000011 . obo:NBO_0000128 obo:IAO_0000115 "Behavior characterized by a quick excitability to annoyance, impatience, or anger." ; dc:date "2011-03-31T12:16:00Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "irritability behavior" ; rdfs:subClassOf obo:NBO_0000121 . obo:NBO_0000129 obo:IAO_0000115 "Emotional behavior related to excitement or restlessness." ; dc:date "2011-03-31T12:22:11Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "agitation behavior" ; rdfs:subClassOf obo:NBO_0000003 . obo:NBO_0000130 obo:IAO_0000115 "A behavior associated with the intake of liquid." ; dc:date "2011-03-31T12:40:37Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "liquid consumption" ; rdfs:subClassOf obo:NBO_0000079, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001548 ] . obo:NBO_0000133 dc:date "2011-03-31T12:41:50Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "liquid preference/aversion" ; rdfs:subClassOf obo:NBO_0000540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] ) ] ] ) ] ] . obo:NBO_0000134 obo:IAO_0000115 "A feeding behavior associated with the intake of food." ; dc:date "2011-03-31T12:42:46Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "food consumption" ; rdfs:subClassOf obo:NBO_0000079, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:CHEBI_33290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000079 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:CHEBI_33290 ] ) ] . obo:NBO_0000135 dc:date "2011-03-31T12:43:07Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "food preference/aversion" ; rdfs:subClassOf obo:NBO_0000539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060259 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000161 ] ) ] ] . obo:NBO_0000141 dc:date "2011-03-31T12:58:43Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "food preference" ; rdfs:subClassOf obo:NBO_0000135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060259 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000912 ] ) ] ] . obo:NBO_0000142 dc:date "2011-03-31T12:59:08Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "food aversion" ; rdfs:subClassOf obo:NBO_0000135 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0060259 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000911 ] ) ] ] . obo:NBO_0000144 dc:date "2011-03-31T02:16:59Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "mating frequency" ; rdfs:subClassOf obo:NBO_0000756 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0007617 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000044 ] ) ] ] . obo:NBO_0000160 dc:date "2011-03-31T03:09:27Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "sleep duration" ; rdfs:subClassOf obo:NBO_0000419 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0030431 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001309 ] ) ] ] . obo:NBO_0000162 obo:IAO_0000115 "Duration of REM sleep." ; dc:date "2011-03-31T03:15:38Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "REM duration" ; rdfs:subClassOf obo:NBO_0000754 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042747 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001309 ] ) ] ] . obo:NBO_0000163 dc:date "2011-03-31T03:15:49Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "REM frequency" ; rdfs:subClassOf obo:NBO_0000754 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042747 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000044 ] ) ] ] . obo:NBO_0000170 obo:IAO_0000115 "Behavior related with the ability of an organism's ability to store, retain, and recall information and experiences." ; dc:date "2011-04-01T01:49:03Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "memory behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0007613" ; a owl:Class ; rdfs:label "memory behavior" ; rdfs:subClassOf obo:NBO_0000006 . obo:NBO_0000229 obo:IAO_0000115 "Observable characteristic of behavior related to the awareness of body balance and movement." ; dc:date "2011-04-04T06:34:21Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "pathological vestibular behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "vestibular behavior phenotype" ; rdfs:subClassOf obo:NBO_0000656 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000317 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000233 obo:IAO_0000115 "Behavior related to the tendency of an organism to maintain internal equilibrium." ; dc:date "2011-04-04T08:29:40Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000050" ; oboInOwl:hasExactSynonym "behavioral homeostasis", "maintenance behaviour", "perception of need" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "motivation behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000243 obo:IAO_0000115 "An observable characteristic of the behavior of an organism." ; dc:date "2011-04-04T08:51:24Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000708" ; a owl:Class ; rdfs:label "behavioral phenotype" . obo:NBO_0000244 dc:date "2011-04-04T08:51:52Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "hysteria", "pathological anxiety disorder" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "pathological anxiety" ; rdfs:subClassOf obo:NBO_0000601 . obo:NBO_0000246 obo:IAO_0000115 "A pathological anxiety characterized by fear or anxiety triggered by a specific stimulus or situation." ; dc:date "2011-04-04T08:52:18Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "phobic disorder" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "phobia" ; rdfs:subClassOf obo:NBO_0000244 . obo:NBO_0000248 obo:IAO_0000115 "\"A pathological anxiety primarily characterized by repetitive obsessions (distressing, persistent, and intrusive thoughts or images) and compulsions (urges to perform specific acts or rituals).\" [wikipedia:Obsessive%E2%80%93compulsive_disorder]" ; dc:date "2011-04-04T08:52:42Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "OCD" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000722" ; a owl:Class ; rdfs:label "obsessive-compulsive disorder" ; rdfs:subClassOf obo:NBO_0000244 . obo:NBO_0000256 dc:date "2011-04-04T08:55:19Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "mood disorder" ; rdfs:subClassOf obo:NBO_0000243 . obo:NBO_0000258 obo:IAO_0000115 "\"A mood disorder formerly characterised by alternating periods of mania and depression (and in some cases rapid cycling, mixed states, and psychotic symptoms).\" [wikipedia:Bipolar_disorder]" ; dc:date "2011-04-04T08:55:45Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "BD", "bipolar affective disorder", "manic depression" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "NBO:0000258" ; a owl:Class ; rdfs:label "bipolar disorder" ; rdfs:subClassOf obo:NBO_0000256 . obo:NBO_0000259 dc:date "2011-04-04T08:56:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000709" ; a owl:Class ; rdfs:label "psychotic disorder" ; rdfs:subClassOf obo:NBO_0000243 . obo:NBO_0000265 dc:date "2011-04-04T08:59:01Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000751" ; a owl:Class ; rdfs:comment "(http://www.cliffsnotes.com/study_guide/Classifying-Psychological-Disorders.topicArticleId-25438,articleId-25396.html)." ; rdfs:label "personality disorder" ; rdfs:subClassOf obo:NBO_0000243 . obo:NBO_0000266 obo:IAO_0000115 "Observable characteristic of behaviour related to cognitive processes." ; dc:date "2011-04-04T09:01:18Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "cognitive behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243, obo:PATO_0000001 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000607 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000268 dc:date "2011-04-04T09:01:50Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000726" ; a owl:Class ; rdfs:label "dementia" ; rdfs:subClassOf obo:NBO_0000266 . obo:NBO_0000270 obo:IAO_0000115 "Observable characteristic of behavior associated with the intake of food or liquids." ; dc:date "2011-04-04T09:02:16Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "feeding behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000079 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000280 dc:date "2011-04-04T09:16:35Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "attraction-related behavior" ; rdfs:subClassOf obo:NBO_0000011 . obo:NBO_0000304 obo:IAO_0000115 "Behavior related with the gradual loss of information and experiences stored in the memory of an organism." ; dc:date "2011-04-04T09:49:14Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "forgetting" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "memory loss behavior" ; rdfs:subClassOf obo:NBO_0000170 . obo:NBO_0000308 obo:IAO_0000115 "Cognitive perception of a sensation by any of the five senses -- vision, touch, smell, taste, and hearing." ; dc:date "2011-04-04T10:00:45Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000454" ; oboInOwl:hasExactSynonym "behavior involving perception", "perception behavior" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:comment "Example: moving head to watch passing object." ; rdfs:label "sensation behavior" ; rdfs:subClassOf obo:NBO_0000607 . obo:NBO_0000313 obo:IAO_0000115 "\"The action, reaction, or performance of an organism in response to external or internal stimuli.\" [GO:GO\\:0007610]" ; dc:date "2011-04-05T09:53:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000000" ; oboInOwl:hasExactSynonym "behavior", "behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0007610" ; a owl:Class ; rdfs:label "behavior process" ; rdfs:subClassOf obo:GO_0007610 . obo:NBO_0000314 obo:IAO_0000115 "\"Behavior related to the actions or reactions of an organism in response to a visual stimulus.\" [GO:0007632]" ; dc:date "2011-04-05T10:36:24Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "behavioral response to visual stimulus", "behavioural response to visual stimulus", "visual behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "visual behavior" ; rdfs:subClassOf obo:NBO_0000308, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0007601 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000308 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0007601 ] ) ] . obo:NBO_0000316 obo:IAO_0000115 "\"Behavior related to the actions or reactions of an organism in response to a sound.\" [GO:0031223]" ; dc:date "2011-04-05T10:38:17Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "hearing behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "GO:0031223" ; a owl:Class ; rdfs:label "auditory behavior" ; rdfs:subClassOf obo:NBO_0000308, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002105 ], [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0007605 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000308 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0007605 ] ) ] . obo:NBO_0000317 obo:IAO_0000115 "Behavior related to the awareness of body balance and movement." ; dc:date "2011-04-05T10:40:36Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "proprioception" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "vestibular behavior" ; rdfs:subClassOf obo:NBO_0000327 . obo:NBO_0000327 obo:IAO_0000115 "Behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." ; dc:date "2011-04-05T11:01:08Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:comment "Sensations arising from the internal organs (the viscera), such as pain or the sense of fullness of the stomach or bladder, may therefore be included, although they are usually considered separately as visceral sensations. Pain arising from the viscera is often felt as though it comes from some part of the body surface or underlying tissue." ; rdfs:label "somatic sensation related behavior" ; rdfs:subClassOf obo:NBO_0000751 . obo:NBO_0000338 obo:IAO_0000115 "\"Movement behavior of the body or its parts.\"" ; dc:date "2011-04-05T02:08:47Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "kinesthetic behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000339 obo:IAO_0000115 "\"The coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions.\" [wikipedia:Motor_coordination]" ; dc:date "2011-04-05T03:32:44Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000340" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "motor coordination" ; rdfs:subClassOf obo:NBO_0000317 . obo:NBO_0000347 obo:IAO_0000115 "The coordination of large muscle groups and whole body movement." ; dc:date "2011-04-05T04:10:52Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "large muscle coordination", "whole body coordination" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "gross motor coordination" ; rdfs:subClassOf obo:NBO_0000339 . obo:NBO_0000355 obo:IAO_0000115 "Intentionally or habitually assumed arrangement of the body and its limbs." ; dc:date "2011-04-06T09:30:15Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "posture" ; rdfs:subClassOf obo:NBO_0000317 . obo:NBO_0000356 obo:IAO_0000115 "Intentionally or habitually assumed arrangement of the body." ; dc:date "2011-04-06T09:30:45Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "body posture" ; rdfs:subClassOf obo:NBO_0000355, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0000309 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000355 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0000309 ] ) ] . obo:NBO_0000357 obo:IAO_0000115 "Intentionally or habitually assumed arrangement of the limbs." ; dc:date "2011-04-06T09:31:06Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "limb posture" ; rdfs:subClassOf obo:NBO_0000355, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000355 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:NBO_0000388 obo:IAO_0000115 "Behavior related to movements that occur independent of planning." ; dc:date "2011-04-06T02:35:38Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:comment "Movevents listed here are involuntary, but may be also generated by free will, like blinking of the eyelids and respiratory movements." ; rdfs:label "involuntary movement behavior" ; rdfs:subClassOf obo:NBO_0000001 ; owl:disjointWith obo:NBO_0000403 . obo:NBO_0000389 obo:IAO_0000115 "Behavior related to involuntary movement in response to a stimulus." ; dc:date "2011-04-06T02:36:55Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000004" ; oboInOwl:hasExactSynonym "reflex behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "reflexive behavior" ; rdfs:subClassOf obo:NBO_0000388, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0060004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000388 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:GO_0060004 ] ) ] . obo:NBO_0000403 obo:IAO_0000115 "Behavior related to movements executed with intent." ; dc:date "2011-04-06T03:32:28Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "voluntary movement behavior" ; rdfs:subClassOf obo:GO_0050882, obo:NBO_0000001 . obo:NBO_0000411 obo:IAO_0000115 "A reflex that involves cranial nerves." ; dc:date "2011-04-06T04:28:27Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "cranial nerve related reflex" ; rdfs:subClassOf obo:NBO_0000389 . obo:NBO_0000416 obo:IAO_0000115 "\"A reflex eye movement that stabilizes images on the retina during head movement by producing an eye movement in the direction opposite to head movement, thus preserving the image on the center of the visual field.\" [wikipedia:Vestibulo-ocular_reflex]" ; dc:date "2011-04-06T06:11:09Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "VOR", "oculovestibular reflex", "vestibuloocular reflex" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "vestibulo-ocular reflex" ; rdfs:subClassOf obo:NBO_0000411 . obo:NBO_0000417 obo:IAO_0000115 "\"A form of involuntary eye movement that is part of the vestibulo-ocular reflex (VOR). It is characterized by alternating smooth pursuit in one direction and saccadic movement in the other direction.\" [wikipedia:Physiologic_nystagmus]" ; dc:date "2011-04-06T06:16:20Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "physiologic nystagmus" ; rdfs:subClassOf obo:NBO_0000416 . obo:NBO_0000419 obo:IAO_0000115 "Observable characteristic of behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." ; dc:date "2011-04-07T01:19:38Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "sleeping behavior phenotype" ; rdfs:subClassOf obo:NBO_0000473 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000024 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000420 obo:IAO_0000115 "A NREM parasomnia characterised by Involuntarily grinding of teeth while sleeping." ; dc:date "2011-04-07T01:20:00Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "", "teeth grinding" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0003763" ; a owl:Class ; rdfs:label "bruxism" ; rdfs:subClassOf obo:NBO_0000499 . obo:NBO_0000444 dc:date "2011-04-08T12:22:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "eye movement" ; rdfs:subClassOf obo:NBO_0000001 . obo:NBO_0000446 obo:IAO_0000115 "Selective tracking that follows a moving object by eye." ; dc:contributor ; dc:date "2011-04-08T12:25:53Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:comment "Original definition: Selectively track a moving object (Source: NBO:GVG)." ; rdfs:label "visual pursuit" ; rdfs:subClassOf obo:GO_0007601, obo:NBO_0000314 . obo:NBO_0000455 obo:IAO_0000115 "The sustained focus of cognitive resources on information while filtering or ignoring extraneous information. Intended to encompass only attention to perceptual stimuli. " ; dc:date "2011-04-08T01:02:16Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "attention behavior" ; rdfs:subClassOf obo:NBO_0000308 . obo:NBO_0000469 obo:IAO_0000115 "\"Behavior related to how the body reacts to a stressor ( a stimulus that causes stress), real or imagined.\" [wikipedia:Stress_(biological)]" ; dc:date "2011-04-08T01:52:36Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:comment "It refers to the consequence of the failure of an organism to respond adequately to mental, emotional or physical demands, whether actual or imagined." ; rdfs:label "stress related behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000473 dc:date "2011-04-08T02:18:40Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "rhythmic behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000008 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000474 dc:date "2011-04-08T02:19:42Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "pathological circadian behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "circadian behavior phenotype" ; rdfs:subClassOf obo:NBO_0000473 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0048512 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000493 obo:IAO_0000115 "A sleeping behavior phenotype that involve abnormal and unnatural movements, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep." ; dc:date "2011-04-08T03:20:06Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "parasomnia" ; rdfs:subClassOf obo:NBO_0000419 . obo:NBO_0000499 obo:IAO_0000115 "A type of parasomnia that occurs during NREM sleep." ; dc:date "2011-04-08T03:37:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "NREM parasomnia" ; rdfs:subClassOf obo:NBO_0000493 . obo:NBO_0000515 dc:date "2011-04-09T12:28:31Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasAlternativeId "NBO:0000523" ; oboInOwl:hasExactSynonym "DD-NOS", "depressive disorder not otherwise specified" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000716" ; a owl:Class ; rdfs:label "depressive disorder" ; rdfs:subClassOf obo:NBO_0000256 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002361 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000085 ] ) ] ] . obo:NBO_0000539 obo:IAO_0000115 "Observable characteristic of feeding behavior that relates to eating." ; dc:date "2011-04-10T10:39:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "eating disorder" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "eating behavior phenotype" ; rdfs:subClassOf obo:NBO_0000270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042755 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000540 obo:IAO_0000115 "Observable characteristic of feeding behavior that relates to drinking." ; dc:date "2011-04-10T10:40:49Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "drinking disorder", "pathological drinking behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "drinking behavior phenotype" ; rdfs:subClassOf obo:NBO_0000270 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042756 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000541 obo:IAO_0000115 "A pathological drinking behavior characterised by an excessive desire to drink." ; dc:date "2011-04-10T10:41:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:note """'participates in' some ('regulation of drinking behavior' and (has_quality some ('increased frequency' and towards some 'liquid consumption' and owl:qualifier some chronic)))""" ; oboInOwl:xref "MP:0002119" ; a owl:Class ; rdfs:label "dipsosis" ; rdfs:subClassOf obo:NBO_0000961 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000380 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] ) ] ] . obo:NBO_0000542 obo:IAO_0000115 "A pathological drinking behavior characterised by large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged." ; dc:date "2011-04-10T10:41:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:note """'participates in' some ( 'regulation of drinking behavior' and regulates some ('liquid consumption' and has-input some ('liquid substance' and has_quality some 'increased mass')) and owl:qualifier some 'temporally extended')""" ; oboInOwl:xref "HP:0001959", "MP:0001426" ; a owl:Class ; rdfs:label "polydipsia" ; rdfs:subClassOf obo:NBO_0000540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf ([ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0000130 ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001548 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001563 ] ) ] ] ) ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001333 ] ) ] ] . obo:NBO_0000543 obo:IAO_0000115 "A pathological drinking behavior characterised by an excessive relative temporal desire to drink." ; dc:date "2011-04-10T10:41:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:note """'participates in' some ('regulation of drinking behavior' and (has_quality some ('increased frequency' and (towards some 'liquid consumption') and (owl:qualifier some 'temporally extended'))))""" ; oboInOwl:xref "MP:0005111" ; a owl:Class ; rdfs:label "hyperdipsia" ; rdfs:subClassOf obo:NBO_0000961 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000380 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001333 ] ) ] ] ) ] ] . obo:NBO_0000544 obo:IAO_0000115 "A pathological feeding behavior characterised by failure to eat." ; dc:date "2011-04-10T10:41:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "MP:0001438" ; a owl:Class ; rdfs:label "aphagia" ; rdfs:subClassOf obo:NBO_0000539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:GO_0042755 ] ) ] ] . obo:NBO_0000546 obo:IAO_0000115 "A pathological eating behavior characterised by an abnormally large intake of food by mouth, usually due to excessive hunger that is relatively prolonged." ; dc:date "2011-04-10T10:41:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "hyperphagia" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000724", "MP:0001433" ; a owl:Class ; rdfs:label "polyphagia" ; rdfs:subClassOf obo:NBO_0000539 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000134 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000912 ] ) ] ] . obo:NBO_0000564 obo:IAO_0000115 "Observable characteristic of behavior that occurs predominantly or only, in individuals that are part of a group." ; dc:date "2011-04-14T08:24:37Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "pathological social behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "social behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0035176 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000567 obo:IAO_0000115 "A pathological behavior associated with repetitive or ritualistic movement, posture, or utterance." ; dc:date "2011-04-14T08:28:29Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "stereotypic behaviour", "stereotypy" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000733", "MP:0001408" ; a owl:Class ; rdfs:label "stereotypic behavior" ; rdfs:subClassOf obo:NBO_0000644 . obo:NBO_0000568 obo:IAO_0000115 "Observable characteristic of behavior related to the movement of the body's muscles, tendons, and joints." ; dc:date "2011-04-14T08:31:34Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "kinesthetic behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000338 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000586 obo:IAO_0000115 "A form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward." ; dc:date "2011-04-14T11:08:01Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0002179", "MP:0002880" ; a owl:Class ; rdfs:label "opisthotonus" ; rdfs:subClassOf obo:NBO_0000587 . obo:NBO_0000587 obo:IAO_0000115 "A sudden, involuntary contraction of a muscle or group of muscles associated with strychnine poisoning and tetanus." ; dc:date "2011-04-14T11:09:10Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "tetanic spasm" ; rdfs:subClassOf obo:NBO_0000588 . obo:NBO_0000588 obo:IAO_0000115 "A sudden, involuntary contraction of a muscle or group of muscles." ; dc:date "2011-04-14T11:10:55Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "spasm" ; rdfs:subClassOf obo:NBO_0000643 . obo:NBO_0000589 obo:IAO_0000115 "An involuntary rhythmical, oscillatory movement of a body part." ; dc:date "2011-04-14T11:13:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "quivering", "shivering", "trembling" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0001337", "MP:0000745" ; a owl:Class ; rdfs:label "tremor" ; rdfs:subClassOf obo:NBO_0000643 . obo:NBO_0000591 obo:IAO_0000115 "Observable characteristic of behavior related to the coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions." ; dc:date "2011-04-14T11:32:30Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "motor coordination phenotype" ; rdfs:subClassOf obo:NBO_0000229 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000339 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000598 obo:IAO_0000115 "A locomotory disorder in which sustained muscle contractions cause twisting and repetitive movements or abnormal postures." ; dc:date "2011-04-14T01:24:20Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0001332", "MP:0005323" ; a owl:Class ; rdfs:label "dystonia" ; rdfs:subClassOf obo:NBO_0000009 . obo:NBO_0000601 obo:IAO_0000115 "Observable characteristic of behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." ; dc:date "2011-04-14T03:07:16Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "emotional behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000602 obo:IAO_0000115 "\"Exhibiting indifference, or suppression of emotions such as concern, excitement, motivation and passion.\" [wikipedia:Indifference_(emotion)]" ; dc:date "2011-04-14T03:07:51Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "impassivity", "perfunctoriness" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000741" ; a owl:Class ; rdfs:label "apathy" ; rdfs:subClassOf obo:NBO_0000601 . obo:NBO_0000603 obo:IAO_0000115 "A belief that is either mistaken or not substantiated that is held with vehemence." ; dc:date "2011-04-14T03:20:48Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000746" ; a owl:Class ; rdfs:label "delusion" ; rdfs:subClassOf obo:NBO_0000266 . obo:NBO_0000604 obo:IAO_0000115 "\"A social behavior characterised by conscious or unconscious constraint of a behavior that might be considered objectionable in a social setting.\" [wikipedia:Social_inhibition]" ; dc:date "2011-04-14T03:33:25Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "social inhibition" ; rdfs:subClassOf obo:NBO_0000011 . obo:NBO_0000605 obo:IAO_0000115 "\"A social behavior characterised by conscious or unconscious constraint or curtailment of behavior relating to specific sexual matters or practices.\" [wikipedia:Sexual_inhibition]" ; dc:date "2011-04-14T03:34:29Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "sexual inhibition" ; rdfs:subClassOf obo:NBO_0000011 . obo:NBO_0000606 obo:IAO_0000115 "Loss of information already encoded and stored in an individual's long term memory." ; dc:date "2011-04-14T03:42:46Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "pathological forgetting", "retention loss" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000747" ; a owl:Class ; rdfs:label "forgetfulness" ; rdfs:subClassOf obo:NBO_0000266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0002361 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000304 ] ) ] ] . obo:NBO_0000607 obo:IAO_0000115 "Behaviour related to cognitive processes." ; dc:date "2011-04-14T03:51:13Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "cognitive behavior" ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0000608 obo:IAO_0000115 "Perception in the absence of a stimulus." ; dc:date "2011-04-14T03:52:31Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0000738" ; a owl:Class ; rdfs:label "hallucination" ; rdfs:subClassOf obo:NBO_0000308 . obo:NBO_0000609 obo:IAO_0000115 "A form of hallucination that involves perceiving images without visual stimulus." ; dc:date "2011-04-14T03:54:02Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "paracusia" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0008765" ; a owl:Class ; rdfs:label "visual hallucination" ; rdfs:subClassOf obo:NBO_0000608, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000608 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002104 ] ) ] . obo:NBO_0000610 obo:IAO_0000115 "\"A form of hallucination that involves perceiving sounds without auditory stimulus.\" [wikipedia:Auditory_hallucination]" ; dc:date "2011-04-14T03:56:24Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0002367" ; a owl:Class ; rdfs:label "auditory hallucination" ; rdfs:subClassOf obo:NBO_0000608, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000608 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0002105 ] ) ] . obo:NBO_0000611 obo:IAO_0000115 "A form of hallucination that involves perceiving odors without odor stimulus." ; dc:date "2011-04-14T03:58:15Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "phantosmia" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "olfactory hallucination" ; rdfs:subClassOf obo:NBO_0000608, [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0005725 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:NBO_0000608 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:UBERON_0005725 ] ) ] . obo:NBO_0000612 obo:IAO_0000115 "A social behavior related to the activity of conveying information." ; dc:date "2011-04-14T04:39:42Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "communicating" ; oboInOwl:hasNarrowSynonym "signal exchange" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "communication behavior" ; rdfs:subClassOf obo:NBO_0000011 . obo:NBO_0000613 obo:IAO_0000115 "\"Communication behavior related to the process of conveying meaning in the form of non-word messages through for example gesture, body language or posture; facial expression and eye contact etc.\" [wikipedia:.wikipedia.org/wiki/Nonverbal_communication]" ; dc:date "2011-04-14T04:40:59Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasExactSynonym "non-verbal communication behaviour", "nonverbal communication behaviour" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "nonverbal communication behavior" ; rdfs:subClassOf obo:NBO_0000612 . obo:NBO_0000616 obo:IAO_0000115 "\"A nonverbal communication behavior that is characterised by the meeting the eyes between two individuals.\" [wikipedia:Eye_contact]" ; dc:date "2011-04-14T04:46:09Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "eye contact" ; rdfs:subClassOf obo:NBO_0000613 . obo:NBO_0000617 dc:date "2011-04-14T04:51:05Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "laughing behavior" ; rdfs:subClassOf obo:NBO_0000003 . obo:NBO_0000620 obo:IAO_0000115 "An emotional behavior that arises from the perceived resistance to the fulfillment of individual will." ; dc:date "2011-04-14T05:00:59Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "frustration behavior" ; rdfs:subClassOf obo:NBO_0000003 . obo:NBO_0000621 obo:IAO_0000115 "\"A communication disorder in which a person, most often a child, who is normally capable of speech is unable to speak in given situations, or to specific people.\" [wikipedia:Selective_mutism]" ; dc:date "2011-04-14T05:06:03Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0002300" ; a owl:Class ; rdfs:label "selective mutism" ; rdfs:subClassOf obo:NBO_0000564 . obo:NBO_0000623 obo:IAO_0000115 "Stereotypic behavior characterised by a tendency to repeat vocalizations." ; dc:date "2011-04-14T05:20:29Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; oboInOwl:xref "HP:0010529" ; a owl:Class ; rdfs:label "echolalia" ; rdfs:subClassOf obo:NBO_0000567 . obo:NBO_0000643 obo:IAO_0000115 "Observable characteristic of behavior related to movements that occur independent of planning." ; dc:date "2011-05-27T11:56:52Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "involuntary movement behavior phenotype" ; rdfs:subClassOf obo:NBO_0000568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000388 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000644 obo:IAO_0000115 "Observable characteristic of behavior related to movements executed with intent." ; dc:date "2011-05-27T11:57:12Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "voluntary movement behavior phenotype" ; rdfs:subClassOf obo:NBO_0000568 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000403 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000655 obo:IAO_0000115 "Observable characteristic of behavior related any of the five senses -- vision, touch, smell, taste, and hearing." ; dc:date "2011-05-27T03:06:17Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "sensation behavior phenotype" ; rdfs:subClassOf obo:NBO_0000266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000308 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000656 obo:IAO_0000115 "A phenotype manifested by a behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." ; dc:date "2011-05-27T03:20:39Z" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "somatic sensation related behavior phenotype" ; rdfs:subClassOf obo:NBO_0000655 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000327 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000741 dc:date "2012-02-16T01:16:31Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "aggressive behavior by means" ; rdfs:subClassOf obo:NBO_0000015 . obo:NBO_0000747 dc:date "2012-03-17T09:51:17Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "jaw movement" ; rdfs:subClassOf obo:NBO_0000007 . obo:NBO_0000751 dc:date "2012-03-16T05:23:06Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "perception behavior by means" ; rdfs:subClassOf obo:NBO_0000308 . obo:NBO_0000754 obo:IAO_0000115 "Observable characteristic of behavior related to the stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." ; dc:date "2012-03-19T11:08:01Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "rapid eye movement sleep phenotype" ; rdfs:subClassOf obo:NBO_0000419, obo:NBO_0000474 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042747 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000755 obo:IAO_0000115 "Observable characteristic of behavior related to the actions or interactions of an organism that are associated with reproduction." ; dc:date "2012-03-19T02:08:56Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "reproductive behavior phenotype" ; rdfs:subClassOf obo:NBO_0000243 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0019098 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000756 obo:IAO_0000115 "Observable characteristic of behavior related to the interactions between organisms for the purpose of mating." ; dc:date "2012-03-19T02:10:16Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "mating behavior phenotype" ; rdfs:subClassOf obo:NBO_0000755 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0007617 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000758 obo:IAO_0000115 "Observable characteristic of behavior related to the activity which primary purpose is the sexual reproduction." ; dc:date "2012-03-19T02:10:54Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "sexual activity phenotype" ; rdfs:subClassOf obo:NBO_0000755 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000034 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000762 obo:IAO_0000115 "Observable characteristic of behavior related to the act of sexual union between male and female, involving the transfer of sperm." ; dc:date "2012-03-19T02:22:41Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "copulation phenotype" ; rdfs:subClassOf obo:NBO_0000758 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0007620 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000765 obo:IAO_0000115 "Observable characteristic of behaviour related to the acquisition and processing of information and/or the storage and retrieval of this information over time." ; dc:date "2012-03-19T02:33:56Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "learning and/or memory behavior phenotype" ; rdfs:subClassOf obo:NBO_0000266 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000006 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000767 obo:IAO_0000115 "Observable characteristic of behaviour related to the ability of an organism's ability to store, retain, and recall information and experiences." ; dc:date "2012-03-19T02:34:26Z" ; oboInOwl:created_by "gkoutos" ; oboInOwl:hasOBONamespace "behavior_ontology" ; a owl:Class ; rdfs:label "memory behavior phenotype" ; rdfs:subClassOf obo:NBO_0000765 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000170 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000001 ] ) ] ] . obo:NBO_0000851 a owl:Class ; rdfs:label "increased amount of liquid in a single drinking act"@en ; rdfs:subClassOf obo:NBO_0000540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0042756 [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001548 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001563 ] ) ] ] ) ] ] . obo:NBO_0000886 a owl:Class ; rdfs:label "increased amount of liquid in drinking regulation"@en ; rdfs:subClassOf obo:NBO_0000540 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001548 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001563 ] ) ] ] ] ) ] ] . obo:NBO_0000929 oboInOwl:note """'participates in' some ('regulation of drinking behavior' and (has_quality some (frequency and (towards some 'liquid consumption'))))""" ; a owl:Class ; rdfs:label "frequency of drinking"@en ; rdfs:subClassOf obo:NBO_0000133 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000044 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] ) ] ] ) ] ] . obo:NBO_0000961 a owl:Class ; rdfs:label "increased frequency of drinking"@en ; rdfs:subClassOf obo:NBO_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000380 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] ) ] ] ) ] ] . obo:NBO_0000993 a owl:Class ; rdfs:label "decreased frequency of drinking"@en ; rdfs:subClassOf obo:NBO_0000929 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000381 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] ) ] ] ) ] ] . obo:NBO_0001786 obo:IAO_0000115 "\"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.\" [GO:0050795]" ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:xref "GO:0050795" ; a owl:Class ; rdfs:label "regulation of behavior"@en ; rdfs:subClassOf obo:NBO_0000313 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0000313 ] . obo:NBO_0001845 obo:IAO_0000115 "Behavior related to the intake of substances." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:hasBroadSynonym "ingest" ; a owl:Class ; rdfs:label "consumption behavior"@en ; rdfs:subClassOf obo:NBO_0000313 . obo:NBO_0002169 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of consumption behavior, the specific actions or reactions of an organism in response to external or internal stimuli." ; oboInOwl:created_by "George Gkoutos" ; a owl:Class ; rdfs:label "regulation of consumption behavior"@en ; rdfs:subClassOf obo:NBO_0001786 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0001845 ] . obo:NBO_0002436 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of consumption of food or liquid" ; oboInOwl:created_by "George Gkoutos" ; a owl:Class ; rdfs:label "regulation of feeding behavior"@en ; rdfs:subClassOf obo:NBO_0002169 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom [ a owl:Class ; owl:unionOf (obo:NBO_0000130 obo:NBO_0000134 ) ] ] . obo:NBO_0002519 obo:IAO_0000115 "A pathological drinking behavior characterised by a lack of desire to drink." ; oboInOwl:created_by "George Gkoutos" ; oboInOwl:xref "MP:0001428" ; a owl:Class ; rdfs:label "adipsia"@en ; rdfs:subClassOf obo:NBO_0000993 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:BFO_0000056 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:NBO_0000064 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000381 [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:NBO_0000130 ] [ a owl:Restriction ; owl:onProperty ; owl:someValuesFrom obo:PATO_0001863 ] ) ] ] ) ] ] . obo:NBO_0002603 obo:IAO_0000115 "Any process that modulates the frequency, rate or extent of sexual activity, the specific actions or reactions of an organism in response to external or internal stimuli." ; oboInOwl:created_by "George Gkoutos" ; a owl:Class ; rdfs:label "regulation of sexual activity"@en ; rdfs:subClassOf obo:NBO_0001786 ; owl:equivalentClass [ a owl:Restriction ; owl:onProperty obo:RO_0002211 ; owl:someValuesFrom obo:NBO_0000034 ] . obo:PATO_0000001 obo:IAO_0000115 "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" ; oboInOwl:hasAlternativeId "PATO:0000072" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000001" ; a owl:Class ; rdfs:label "quality" . obo:PATO_0000004 obo:IAO_0000115 "A quality of inhering in a bearer by virtue of the bearer's disposition to move freely." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000004" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "Should be defined using translocation." ; rdfs:label "mobility" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000014 obo:IAO_0000115 "A composite chromatic quality composed of hue, saturation and intensity parts." ; oboInOwl:hasAlternativeId "PATO:0000020" ; oboInOwl:hasExactSynonym "colour", "relative color" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000014" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "color" ; rdfs:subClassOf obo:PATO_0000051, obo:PATO_0001300 . obo:PATO_0000016 obo:IAO_0000115 "A scalar optical property that is the intensity, value or amount of perceived light." ; oboInOwl:hasExactSynonym "color intensity", "color lightness", "color value" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000016" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "Color brightness refers to the intensity, lightness or value of the light present. Think of this as a dimmer switch." ; rdfs:label "color brightness" ; rdfs:subClassOf obo:PATO_0001300 . obo:PATO_0000017 obo:IAO_0000115 "A scalar chromatic property that is the degree of purity of perceived light." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000017" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "Color saturation refers to the amount of white light or gray paint mixed in with the hue (single wavelength) and is a measure of color purity." ; rdfs:label "color saturation" ; rdfs:subClassOf obo:PATO_0001301 . obo:PATO_0000025 obo:IAO_0000115 "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." ; oboInOwl:hasAlternativeId "PATO:0002015" ; oboInOwl:hasExactSynonym "composed of", "compositionality", "content", "structure, composition" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000025" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood)." ; rdfs:label "composition" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000033 obo:IAO_0000115 "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." ; oboInOwl:hasExactSynonym "concentration" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000033" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "concentration of" ; rdfs:subClassOf obo:PATO_0002182 . obo:PATO_0000044 obo:IAO_0000115 "A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000044" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "frequency" ; rdfs:subClassOf obo:PATO_0050000 . obo:PATO_0000047 obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000047" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "biological sex" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000048 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "impenetrability", "toughness" ; oboInOwl:id "PATO:0000048" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim ; a owl:Class ; rdfs:label "hardness" ; rdfs:subClassOf obo:PATO_0001546 . obo:PATO_0000049 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000049" ; oboInOwl:inSubset pato:attribute_slim, pato:hpo_slim ; a owl:Class ; rdfs:label "intensity" ; rdfs:subClassOf obo:PATO_0000068 . obo:PATO_0000050 obo:IAO_0000115 "A time quality inhering in a bearer by virtue of the bearer's expected maximum age." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000050" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "life span" ; rdfs:subClassOf obo:PATO_0000165 . obo:PATO_0000051 obo:IAO_0000115 "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000051" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "morphology" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0000052 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." ; oboInOwl:hasAlternativeId "PATO:0001647" ; oboInOwl:hasExactSynonym "relational shape quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000052" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects." ; rdfs:label "shape" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000057 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." ; oboInOwl:hasAlternativeId "PATO:0000156", "PATO:0000158" ; oboInOwl:hasBroadSynonym "temporal" ; oboInOwl:hasExactSynonym "incidence" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000057" ; oboInOwl:inSubset pato:attribute_slim, pato:hpo_slim ; a owl:Class ; rdfs:label "occurrence" ; rdfs:subClassOf obo:PATO_0002323 . obo:PATO_0000060 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts." ; oboInOwl:hasAlternativeId "PATO:0000132", "PATO:0001565" ; oboInOwl:hasExactSynonym "distribution" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "pattern" ; oboInOwl:id "PATO:0000060" ; oboInOwl:inSubset pato:attribute_slim, pato:hpo_slim ; a owl:Class ; rdfs:label "spatial pattern" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000068 oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000068" ; a owl:Class ; rdfs:comment "TODO: define this or obsolete it and move children somewhere else." ; rdfs:label "qualitative" ; rdfs:subClassOf obo:PATO_0000001 . obo:PATO_0000069 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000069" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "deviation (from_normal)" ; rdfs:subClassOf obo:PATO_0000068 . obo:PATO_0000070 obo:IAO_0000115 "The number of entities of this type that are part of the whole organism." ; oboInOwl:hasAlternativeId "PATO:0000053", "PATO:0000071", "PATO:0001169", "PATO:0001226" ; oboInOwl:hasExactSynonym "presence or absence in organism", "quantitative" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "count in organism", "number", "presence" ; oboInOwl:id "PATO:0000070" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "This term was originally named \"presence\". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10." ; rdfs:label "amount" ; rdfs:subClassOf obo:PATO_0000068, [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0001555 ] . obo:PATO_0000078 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's movement or variation characterized by the regular recurrence or alternation of different quantities or conditions." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000078" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "rhythm quality" ; rdfs:subClassOf obo:PATO_0002323 . obo:PATO_0000082 obo:IAO_0000115 "A rhythm quality inhering in a bearer by virtue of the repetitiveness of bearer's rhythm." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000082" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "persistence" ; rdfs:subClassOf obo:PATO_0000078 . obo:PATO_0000085 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation." ; oboInOwl:hasExactSynonym "sensitivity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000085" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim ; a owl:Class ; rdfs:label "sensitivity toward" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000117 obo:IAO_0000115 "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000117" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "size" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000119 obo:IAO_0000115 "A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000119" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "height" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0000122 obo:IAO_0000115 "A 1-D extent quality which is equal to the distance between two points." ; pato:seeAlso "https://github.com/pato-ontology/pato/issues/337" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000122" ; oboInOwl:inSubset pato:attribute_slim, pato:mpath_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion." ; rdfs:label "length" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0000125 obo:IAO_0000115 "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000125" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ; rdfs:label "mass" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000133 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object." ; oboInOwl:hasAlternativeId "PATO:0000137" ; oboInOwl:hasExactSynonym "angular placement" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "amount of rotation", "angle", "angular magnitude", "plane angle" ; oboInOwl:id "PATO:0000133" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "orientation" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0000136 obo:IAO_0000115 "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000136" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "closure" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000140 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." ; oboInOwl:hasAlternativeId "PATO:0001032", "PATO:0001631" ; oboInOwl:hasExactSynonym "location", "placement", "relational spatial quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000140" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "position" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000141 obo:IAO_0000115 "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." ; oboInOwl:hasAlternativeId "PATO:0001452" ; oboInOwl:hasBroadSynonym "conformation" ; oboInOwl:hasExactSynonym "relational structural quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000141" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "structure" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000150 obo:IAO_0000115 "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000150" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "texture" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0000161 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000161" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "rate" ; rdfs:subClassOf obo:PATO_0002062 . obo:PATO_0000165 obo:IAO_0000115 "A quality in which events occur in sequence." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000165" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "time" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0000186 obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation." ; oboInOwl:hasAlternativeId "PATO:0001722" ; oboInOwl:hasExactSynonym "behavioural quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000186" ; a owl:Class ; rdfs:label "behavioral quality" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000188 obo:IAO_0000115 "A behavioral quality inhering in a bearer by virtue of the bearer's having or lacking skillful and effective interaction of movement." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000188" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "coordination" ; rdfs:subClassOf obo:PATO_0000186 . obo:PATO_0000261 obo:IAO_0000115 "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000261" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "maturity" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0000274 obo:IAO_0000115 "A reproductive quality inhering in a bearer by virtue of the bearer's initiating, sustaining, or supporting reproduction." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000274" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim ; a owl:Class ; rdfs:label "fertility" ; rdfs:subClassOf obo:PATO_0001434 . obo:PATO_0000297 obo:IAO_0000115 "A quality of a process which ends earlier than the natural end time or reference process." ; oboInOwl:hasAlternativeId "PATO:0001508" ; oboInOwl:hasExactSynonym "abolished" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "incomplete" ; oboInOwl:id "PATO:0000297" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:comment "TODO: the definition is incorrect. See absent." ; rdfs:label "arrested" ; rdfs:subClassOf obo:PATO_0002052, obo:PATO_0002324, [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] . obo:PATO_0000299 obo:IAO_0000115 "A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely." ; obo:RO_0002604 obo:PATO_0000300 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000299" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "mobile" ; rdfs:subClassOf obo:PATO_0000004 . obo:PATO_0000318 obo:IAO_0000115 "A color hue with low wavelength of that portion of the visible spectrum lying between green and indigo, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 490 nanometers." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000318" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "blue" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000319 obo:IAO_0000115 "A color consisting of green and blue hue." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000319" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "cyan" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000320 obo:IAO_0000115 "A color hue with medium-low wavelength of that portion of the visible spectrum lying between yellow and blue, evoked in the human observer by radiant energy with wavelengths of approximately 490 to 570 nanometers." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000320" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "green" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000322 obo:IAO_0000115 "A color hue with high wavelength of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately 630 to 750 nanometers." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000322" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "red" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000323 obo:IAO_0000115 "An achromatic color of maximum brightness; the color of objects that reflect nearly all light of all visible wavelengths." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "whitish" ; oboInOwl:id "PATO:0000323" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "white" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000328 obo:IAO_0000115 "A color saturation which is of low purity." ; obo:RO_0002604 obo:PATO_0001229 ; oboInOwl:hasExactSynonym "pale" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "dull" ; oboInOwl:id "PATO:0000328" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "low saturation" ; rdfs:subClassOf obo:PATO_0000017 . obo:PATO_0000330 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency." ; obo:RO_0002604 obo:PATO_0000440 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000330" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "irregular spatial pattern" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000380 obo:IAO_0000115 "A frequency which is relatively high." ; obo:RO_0002604 obo:PATO_0000381 ; oboInOwl:hasExactSynonym "high frequency" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "frequent" ; oboInOwl:id "PATO:0000380" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased frequency" ; rdfs:subClassOf obo:PATO_0000044, obo:PATO_0000912 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000044 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000381 obo:IAO_0000115 "A frequency which is relatively low." ; obo:RO_0002604 obo:PATO_0000380 ; oboInOwl:hasExactSynonym "low frequency" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "infrequent" ; oboInOwl:id "PATO:0000381" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased frequency" ; rdfs:subClassOf obo:PATO_0000044, obo:PATO_0000911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000044 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000386 obo:IAO_0000115 "A hardness quality of being rigid and resistant to pressure." ; obo:RO_0002604 obo:PATO_0000387 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "firm", "impenetrable", "tough" ; oboInOwl:id "PATO:0000386" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "hard" ; rdfs:subClassOf obo:PATO_0000048, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000048 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000387 obo:IAO_0000115 "A hardness quality of giving little resistance to pressure." ; obo:RO_0002604 obo:PATO_0000386 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000387" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "soft" ; rdfs:subClassOf obo:PATO_0000048, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000048 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000389 obo:IAO_0000115 "A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course." ; obo:RO_0002604 obo:PATO_0001863 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000389" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "acute" ; rdfs:subClassOf obo:PATO_0001309 . obo:PATO_0000394 obo:IAO_0000115 "An intensity which is less than moderate in type or degree or effect or force." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000394" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "mild intensity" ; rdfs:subClassOf obo:PATO_0000049 . obo:PATO_0000395 obo:IAO_0000115 "An intensity which is less than extreme in type or degree or effect or force." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000395" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "moderate intensity" ; rdfs:subClassOf obo:PATO_0000049 . obo:PATO_0000396 obo:IAO_0000115 "An intensity which is extremely bad or unpleasant in type or degree or effect or force." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000396" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "severe intensity" ; rdfs:subClassOf obo:PATO_0000049 . obo:PATO_0000402 obo:IAO_0000115 "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." ; obo:RO_0002604 obo:PATO_0000414 ; oboInOwl:hasExactSynonym "ramified", "ramiform" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000402" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "branched" ; rdfs:subClassOf obo:PATO_0002009 . obo:PATO_0000403 obo:IAO_0000115 "A concave quality inhering in a bearer by virtue of the bearer's resembling a groove or fissure." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000403" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "cleft" ; rdfs:subClassOf obo:PATO_0001857 . obo:PATO_0000404 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals)." ; obo:RO_0002604 obo:PATO_0000415 ; oboInOwl:hasAlternativeId "PATO:0001363" ; oboInOwl:hasExactSynonym "spiral" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "helical", "helicoid", "helicoidal", "helix-shaped" ; oboInOwl:id "PATO:0000404" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "coiled" ; rdfs:subClassOf obo:PATO_0001794 . obo:PATO_0000405 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000405" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "curled" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0000406 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend." ; oboInOwl:hasNarrowSynonym "bowing" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "curled" ; oboInOwl:id "PATO:0000406" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "curved" ; rdfs:subClassOf obo:PATO_0001591 . obo:PATO_0000407 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "plate-like" ; oboInOwl:id "PATO:0000407" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "flat" ; rdfs:subClassOf obo:PATO_0002254 . obo:PATO_0000411 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "round", "rounded" ; oboInOwl:id "PATO:0000411" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "circular" ; rdfs:subClassOf obo:PATO_0000947 . obo:PATO_0000413 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000413" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "square" ; rdfs:subClassOf obo:PATO_0002317 . obo:PATO_0000427 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's occurring or appearing again or repeatedly." ; obo:RO_0002604 obo:PATO_0000428 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000427" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "recurrent" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0000440 obo:IAO_0000115 "A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement." ; obo:RO_0002604 obo:PATO_0000330 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000440" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "regular spatial pattern" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000460 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." ; obo:RO_0002604 obo:PATO_0000461 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "aberrant", "atypia", "atypical", "defective" ; oboInOwl:id "PATO:0000460" ; oboInOwl:inSubset pato:abnormal_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "abnormal" ; rdfs:subClassOf obo:PATO_0000069 . obo:PATO_0000461 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." ; obo:RO_0002604 obo:PATO_0000460 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "average" ; oboInOwl:id "PATO:0000461" ; oboInOwl:inSubset pato:abnormal_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal" ; rdfs:subClassOf obo:PATO_0000068 . obo:PATO_0000462 obo:IAO_0000115 "A quality denoting the lack of an entity." ; obo:RO_0002604 obo:PATO_0000467 ; oboInOwl:hasAlternativeId "PATO:0001996" ; oboInOwl:hasExactSynonym "absence", "absent from organism" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000462" ; oboInOwl:inSubset pato:absent_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment """We recommend using the new absent terms (physical absence, absent anatomical entity, or absent process) instead of this class. This is a legacy term and will ultimately be obsoleted. See https://github.com/pato-ontology/pato/issues/331.""" ; rdfs:label "absent" ; rdfs:subClassOf obo:PATO_0000070, [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0001558 ], [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0002000 ] ; owl:disjointWith obo:PATO_0000467 . obo:PATO_0000467 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's existence." ; obo:RO_0002604 obo:PATO_0000462 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "present in organism" ; oboInOwl:id "PATO:0000467" ; oboInOwl:inSubset pato:absent_slim, pato:value_slim ; a owl:Class ; rdfs:label "present" ; rdfs:subClassOf obo:PATO_0000070 . obo:PATO_0000470 obo:IAO_0000115 "An amount which is relatively high." ; obo:RO_0002604 obo:PATO_0001997 ; oboInOwl:hasAlternativeId "PATO:0000420", "PATO:0000650" ; oboInOwl:hasExactSynonym "increased number", "present in greater numbers in organism", "supernumerary" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "accessory", "increased" ; oboInOwl:id "PATO:0000470" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased amount" ; rdfs:subClassOf obo:PATO_0000467, obo:PATO_0002300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000498 obo:IAO_0000115 "A duration quality of a process which is relatively high." ; obo:RO_0002604 obo:PATO_0000499 ; oboInOwl:hasAlternativeId "PATO:0000715" ; oboInOwl:hasExactSynonym "high time", "increased period", "increased time" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "chronic", "prolonged period", "slow time" ; oboInOwl:id "PATO:0000498" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased duration" ; rdfs:subClassOf obo:PATO_0001309, obo:PATO_0002304 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001309 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000499 obo:IAO_0000115 "A duration quality of a process which is relatively low." ; obo:RO_0002604 obo:PATO_0000498 ; oboInOwl:hasAlternativeId "PATO:0000716" ; oboInOwl:hasExactSynonym "decreased period", "decreased time", "low period", "shortened period" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "fast time" ; oboInOwl:id "PATO:0000499" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased duration" ; rdfs:subClassOf obo:PATO_0001309, obo:PATO_0002302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001309 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000502 obo:IAO_0000115 "A quality of a process which starts later than the natural start time or the reference process." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "late" ; oboInOwl:id "PATO:0000502" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "delayed" ; rdfs:subClassOf obo:PATO_0002325 . obo:PATO_0000516 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus." ; obo:RO_0002604 obo:PATO_0000513 ; oboInOwl:hasExactSynonym "sensitive" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000516" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "sensitive toward" ; rdfs:subClassOf obo:PATO_0000085 . obo:PATO_0000547 obo:IAO_0000115 "A photosensitivity quality inhering in a bearer by virtue of the bearer's exhibiting photosensitivity." ; obo:RO_0002604 obo:PATO_0000546 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000547" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "photosensitive" ; rdfs:subClassOf obo:PATO_0000927 . obo:PATO_0000569 obo:IAO_0000115 "A height which is relatively low." ; obo:RO_0002604 obo:PATO_0000570 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "short" ; oboInOwl:id "PATO:0000569" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased height" ; rdfs:subClassOf obo:PATO_0000119, obo:PATO_0000587 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000570 obo:IAO_0000115 "A height which is relatively high." ; obo:RO_0002604 obo:PATO_0000569 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "tall" ; oboInOwl:id "PATO:0000570" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased height" ; rdfs:subClassOf obo:PATO_0000119, obo:PATO_0000586 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000573 obo:IAO_0000115 "A length quality which is relatively large." ; obo:RO_0002604 obo:PATO_0000574 ; oboInOwl:hasExactSynonym "long" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000573" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased length" ; rdfs:subClassOf obo:PATO_0000122, obo:PATO_0000586 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000574 obo:IAO_0000115 "A length quality which is relatively small." ; obo:RO_0002604 obo:PATO_0000573 ; oboInOwl:hasExactSynonym "short" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "shortened", "stubby" ; oboInOwl:id "PATO:0000574" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased length" ; rdfs:subClassOf obo:PATO_0000122, obo:PATO_0000587 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000584 obo:IAO_0000115 "An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ)." ; obo:RO_0002604 obo:PATO_0000585 ; oboInOwl:hasNarrowSynonym "hypertrophy" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000584" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "hypertrophic" ; rdfs:subClassOf obo:PATO_0000595 . obo:PATO_0000585 obo:IAO_0000115 "A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ)." ; obo:RO_0002604 obo:PATO_0000584 ; oboInOwl:hasAlternativeId "PATO:0000412" ; oboInOwl:hasExactSynonym "shrunken" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000585" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "hypotrophic" ; rdfs:subClassOf obo:PATO_0000596 . obo:PATO_0000586 obo:IAO_0000115 "A size quality which is relatively high." ; obo:RO_0002604 obo:PATO_0000587 ; oboInOwl:hasAlternativeId "PATO:0001202" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "big", "enlarged", "expanded", "great", "large" ; oboInOwl:id "PATO:0000586" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased size" ; rdfs:subClassOf obo:PATO_0000117, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000587 obo:IAO_0000115 "A size quality which is relatively low." ; obo:RO_0002604 obo:PATO_0000586 ; oboInOwl:hasNarrowSynonym "hypoplasia", "underdeveloped" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "reduced", "small", "tiny" ; oboInOwl:id "PATO:0000587" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased size" ; rdfs:subClassOf obo:PATO_0000117, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000591 obo:IAO_0000115 "A thickness which is relatively high." ; obo:RO_0002604 obo:PATO_0000592 ; oboInOwl:hasExactSynonym "high thickness", "stout", "thickened" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "thick" ; oboInOwl:id "PATO:0000591" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased thickness" ; rdfs:subClassOf obo:PATO_0000586, obo:PATO_0000915 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000915 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000592 obo:IAO_0000115 "A thickness which is relatively low." ; obo:RO_0002604 obo:PATO_0000591 ; oboInOwl:hasExactSynonym "low thickness" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "slender", "thin" ; oboInOwl:id "PATO:0000592" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased thickness" ; rdfs:subClassOf obo:PATO_0000587, obo:PATO_0000915 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000915 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000595 obo:IAO_0000115 "A volume which is relatively high." ; obo:RO_0002604 obo:PATO_0000596 ; oboInOwl:hasExactSynonym "high volume" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "large volume" ; oboInOwl:id "PATO:0000595" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased volume" ; rdfs:subClassOf obo:PATO_0000586, obo:PATO_0000918 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000918 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000596 obo:IAO_0000115 "A volume which is relatively low." ; obo:RO_0002604 obo:PATO_0000595 ; oboInOwl:hasExactSynonym "low volume" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "small volume" ; oboInOwl:id "PATO:0000596" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased volume" ; rdfs:subClassOf obo:PATO_0000587, obo:PATO_0000918 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000918 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000599 obo:IAO_0000115 "A width which is relatively small." ; obo:RO_0002604 obo:PATO_0000600 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "narrow" ; oboInOwl:id "PATO:0000599" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased width" ; rdfs:subClassOf obo:PATO_0000587, obo:PATO_0000921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000600 obo:IAO_0000115 "A width which is relatively large." ; obo:RO_0002604 obo:PATO_0000599 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "broad", "wide", "wide/broad" ; oboInOwl:id "PATO:0000600" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased width" ; rdfs:subClassOf obo:PATO_0000586, obo:PATO_0000921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000608 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." ; obo:RO_0002604 obo:PATO_0000610 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "blocked" ; oboInOwl:id "PATO:0000608" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "closed" ; rdfs:subClassOf obo:PATO_0000136 ; owl:disjointWith obo:PATO_0000610 . obo:PATO_0000609 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's affording not completed blocked passage or view." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000609" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "closure incomplete" ; rdfs:subClassOf obo:PATO_0000610 . obo:PATO_0000610 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view." ; obo:RO_0002604 obo:PATO_0000608 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000610" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "open" ; rdfs:subClassOf obo:PATO_0000136 . obo:PATO_0000614 obo:IAO_0000115 "A pattern where all the repeated elements are oriented in the same direction." ; obo:RO_0002604 obo:PATO_0000613 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000614" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "oriented" ; rdfs:subClassOf obo:PATO_0000440 . obo:PATO_0000616 obo:IAO_0000115 "A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry." ; oboInOwl:hasExactSynonym "asymmetric", "asymmetry" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000616" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "asymmetrical" ; rdfs:subClassOf obo:PATO_0000965 . obo:PATO_0000617 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length." ; oboInOwl:hasExactSynonym "angled", "flexed" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000617" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "bent" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0000618 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000618" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "bilateral" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0000619 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being overfilled." ; obo:RO_0002604 obo:PATO_0000633 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000619" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "crowded" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0000623 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's protruding or projecting from the body." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "prolapse", "prolapsed" ; oboInOwl:id "PATO:0000623" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "exserted" ; rdfs:subClassOf obo:PATO_0001598 . obo:PATO_0000625 obo:IAO_0000115 "An oriented quality inhering in a bearer by virtue of the bearer's being reversed in position, order, or condition." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "backward", "reversed" ; oboInOwl:id "PATO:0000625" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "inverted" ; rdfs:subClassOf obo:PATO_0000614 . obo:PATO_0000627 obo:IAO_0000115 "A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location." ; oboInOwl:hasExactSynonym "focal", "localised" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000627" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "localized" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000628 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position." ; oboInOwl:hasAlternativeId "PATO:0000621" ; oboInOwl:hasExactSynonym "ectopic", "mislocalized" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000628" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "mislocalised" ; rdfs:subClassOf obo:PATO_0002181 . obo:PATO_0000632 obo:IAO_0000115 "A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division by a longitudinal plane into similar halves." ; oboInOwl:hasExactSynonym "symmetric" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000632" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment "similar pattern in both halves" ; rdfs:label "symmetrical" ; rdfs:subClassOf obo:PATO_0000440, obo:PATO_0000965 . obo:PATO_0000634 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's involvement of only one part or side." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000634" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "unilateral" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000635 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's not being confined or restricted to a particular location." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000635" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "unlocalised" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000639 obo:IAO_0000115 "A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process." ; obo:RO_0002604 obo:PATO_0002038 ; oboInOwl:hasNarrowSynonym "degeneration" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000639" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "degenerate" ; rdfs:subClassOf obo:PATO_0002037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PATO_0000585 ] ; owl:disjointWith obo:PATO_0001623 . obo:PATO_0000640 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's exhibiting an alteration in size, shape or organization of its constituent cells." ; oboInOwl:hasNarrowSynonym "dysplasia" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000640" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dysplastic" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000642 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity." ; obo:RO_0002604 obo:PATO_0000651 ; oboInOwl:hasExactSynonym "fused", "fused to" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "coalesced", "joined with", "merged with" ; oboInOwl:id "PATO:0000642" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "fused with" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000643 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000643" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "herniated" ; rdfs:subClassOf obo:PATO_0001598 . obo:PATO_0000644 obo:IAO_0000115 "A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting an increased number of cells, typically associated with an increase in size." ; obo:RO_0002604 obo:PATO_0000645 ; oboInOwl:hasAlternativeId "PATO:0000943" ; oboInOwl:hasExactSynonym "hyperplasia" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "overdeveloped" ; oboInOwl:id "PATO:0000644" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "hyperplastic" ; rdfs:subClassOf obo:PATO_0002305 . obo:PATO_0000645 obo:IAO_0000115 "A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting a decreased number of cells, typically associated with a decrease in size." ; obo:RO_0002604 obo:PATO_0000644 ; oboInOwl:hasAlternativeId "PATO:0000942" ; oboInOwl:hasExactSynonym "hypoplasia" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "underdeveloped" ; oboInOwl:id "PATO:0000645" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "hypoplastic" ; rdfs:subClassOf obo:PATO_0002290, obo:PATO_0002303 . obo:PATO_0000646 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation." ; oboInOwl:hasNarrowSynonym "malformation" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000646" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "malformed" ; rdfs:subClassOf obo:PATO_0001617 . obo:PATO_0000647 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's undergoing unprogrammed cell death." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000647" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "necrotic" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000648 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's being blocked or filled with obstacles or an obstacle." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000648" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "obstructed" ; rdfs:subClassOf obo:PATO_0000608 . obo:PATO_0000651 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's being no longer merged with another entity." ; obo:RO_0002604 obo:PATO_0000642 ; oboInOwl:hasExactSynonym "unfused" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000651" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "unfused from" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0000665 obo:IAO_0000115 "A color brightness which is relatively high." ; obo:RO_0002604 obo:PATO_0000327 ; oboInOwl:hasExactSynonym "light" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000665" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "high brightness" ; rdfs:subClassOf obo:PATO_0000016 . obo:PATO_0000688 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's not occurring or existing at the same time or having the same period or phase." ; obo:RO_0002604 obo:PATO_0000695 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000688" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "asynchronous" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0000689 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent." ; obo:RO_0002604 obo:PATO_0000690 ; oboInOwl:hasAlternativeId "PATO:0000429" ; oboInOwl:hasExactSynonym "uninterrupted" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000689" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "continuous" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0000692 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's origin or development at an unusual time or out of the regular sequence." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000692" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "heterochronic" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0000694 obo:IAO_0000115 "A quality of a process which starts earlier than the natural start time or the reference process." ; oboInOwl:hasAlternativeId "PATO:0000691", "PATO:0002086" ; oboInOwl:hasExactSynonym "advanced" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "early", "precocious" ; oboInOwl:id "PATO:0000694" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "premature" ; rdfs:subClassOf obo:PATO_0002325 . obo:PATO_0000700 obo:IAO_0000115 "A texture quality inhering in a bearer by virtue of the bearer's irregular surface." ; obo:RO_0002604 obo:PATO_0000701 ; oboInOwl:hasAlternativeId "PATO:0001616" ; oboInOwl:hasExactSynonym "coarse" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000700" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "rough" ; rdfs:subClassOf obo:PATO_0000150 . obo:PATO_0000701 obo:IAO_0000115 "A texture quality inhering in a bearer by virtue of the bearer's processing a surface free of roughness or irregularities." ; obo:RO_0002604 obo:PATO_0000700 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000701" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "smooth" ; rdfs:subClassOf obo:PATO_0000150 . obo:PATO_0000760 obo:IAO_0000115 "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting increased activity." ; obo:RO_0002604 obo:PATO_0000761 ; oboInOwl:hasExactSynonym "hyperactive" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000760" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased behavioural activity" ; rdfs:subClassOf obo:PATO_0001707, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001707 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000761 obo:IAO_0000115 "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting reduced activity." ; obo:RO_0002604 obo:PATO_0000760 ; oboInOwl:hasExactSynonym "hypoactive" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000761" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased behavioural activity" ; rdfs:subClassOf obo:PATO_0001707, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001707 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000763 obo:IAO_0000115 "A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part." ; oboInOwl:hasNarrowSynonym "palsy" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000763" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "paralysed" ; rdfs:subClassOf obo:PATO_0002076 . obo:PATO_0000890 obo:IAO_0000115 "A male fertility quality inhering in a male by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." ; obo:RO_0002604 obo:PATO_0000891 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "male infertile" ; oboInOwl:id "PATO:0000890" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "male sterile" ; rdfs:subClassOf obo:PATO_0000956 . obo:PATO_0000892 obo:IAO_0000115 "A female fertility quality inhering in a female by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." ; obo:RO_0002604 obo:PATO_0000888 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "female infertile" ; oboInOwl:id "PATO:0000892" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "female sterile" ; rdfs:subClassOf obo:PATO_0000956 . obo:PATO_0000911 obo:IAO_0000115 "A rate which is relatively low." ; obo:RO_0002604 obo:PATO_0000912 ; oboInOwl:hasExactSynonym "slow rate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000911" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased rate" ; rdfs:subClassOf obo:PATO_0000161, obo:PATO_0002302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000912 obo:IAO_0000115 "A rate which is relatively high." ; obo:RO_0002604 obo:PATO_0000911 ; oboInOwl:hasExactSynonym "fast rate", "high rate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000912" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased rate" ; rdfs:subClassOf obo:PATO_0000161, obo:PATO_0002304 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0000915 obo:IAO_0000115 "A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width." ; pato:seeAlso "https://github.com/pato-ontology/pato/issues/337" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000915" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "Thickness often refers to the smallest 1-D extent compared to the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion." ; rdfs:label "thickness" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0000918 obo:IAO_0000115 "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000918" ; oboInOwl:inSubset pato:attribute_slim, pato:mpath_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "volume" ; rdfs:subClassOf obo:PATO_0001710 . obo:PATO_0000921 obo:IAO_0000115 "A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite." ; pato:seeAlso "https://github.com/pato-ontology/pato/issues/337" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "breadth" ; oboInOwl:id "PATO:0000921" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "Width often refers to the dimension that is greater than the extent in only one of the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion." ; rdfs:label "width" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0000927 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000927" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "photosensitivity" ; rdfs:subClassOf obo:PATO_0000085 . obo:PATO_0000941 obo:IAO_0000115 "A structural quality inhering in a cytoplasm that contains fluid filled cavities." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000941" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "vacuolated" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0000944 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point." ; oboInOwl:hasExactSynonym "apiculate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000944" ; oboInOwl:inSubset pato:attribute_slim, pato:cell_quality ; a owl:Class ; rdfs:label "sharpness" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0000946 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having a somewhat elongated form with approximately parallel sides." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000946" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "oblong" ; rdfs:subClassOf obo:PATO_0002006 . obo:PATO_0000947 obo:IAO_0000115 "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." ; oboInOwl:hasExactSynonym "ellipse-shaped", "ellipsoid", "elliptical" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "oval", "ovoid" ; oboInOwl:id "PATO:0000947" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "elliptic" ; rdfs:subClassOf obo:PATO_0002318 . obo:PATO_0000950 obo:IAO_0000115 "A color between white and black colors." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "plumbeous" ; oboInOwl:id "PATO:0000950" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "grey" ; rdfs:subClassOf obo:PATO_0000014 . obo:PATO_0000956 obo:IAO_0000115 "A fertility quality inhering in a bearer by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." ; obo:RO_0002604 obo:PATO_0000955 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000956" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "sterile" ; rdfs:subClassOf obo:PATO_0000274 . obo:PATO_0000957 obo:IAO_0000115 "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000957" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "opacity" ; rdfs:subClassOf obo:PATO_0001300 . obo:PATO_0000963 obo:IAO_0000115 "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." ; obo:RO_0002604 obo:PATO_0000964 ; oboInOwl:hasExactSynonym "non-transparent" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "clouding", "cloudy" ; oboInOwl:id "PATO:0000963" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "opaque" ; rdfs:subClassOf obo:PATO_0000957 . obo:PATO_0000964 obo:IAO_0000115 "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." ; obo:RO_0002604 obo:PATO_0000963 ; oboInOwl:hasExactSynonym "clear", "hyaline" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000964" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "transparent" ; rdfs:subClassOf obo:PATO_0000957 . obo:PATO_0000965 obo:IAO_0000115 "A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000965" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "symmetry" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0000967 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having a sinuate margin and rippled surface." ; oboInOwl:hasAlternativeId "PATO:0001610", "PATO:0001939" ; oboInOwl:hasExactSynonym "undulated", "undulating", "waved", "wavy" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "rippled", "sinuate" ; oboInOwl:id "PATO:0000967" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "undulate" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0000969 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of the bearer's being abnormally small." ; oboInOwl:hasExactSynonym "dwarfed" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000969" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "dwarf-like" ; rdfs:subClassOf obo:PATO_0000587 . obo:PATO_0000992 obo:IAO_0000115 "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000992" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim ; a owl:Class ; rdfs:label "viscosity" ; rdfs:subClassOf obo:PATO_0001548 . obo:PATO_0000998 obo:IAO_0000115 "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0000998" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "viscous" ; rdfs:subClassOf obo:PATO_0000992 . obo:PATO_0001018 obo:IAO_0000115 "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." ; oboInOwl:hasAlternativeId "PATO:0002079" ; oboInOwl:hasDbXref "Wikipedia:Physical_property" ; oboInOwl:hasExactSynonym "relational physical quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001018" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "physical quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001019 obo:IAO_0000115 "A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "density" ; oboInOwl:id "PATO:0001019" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "mass density" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001020 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001020" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "damage" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001025 obo:IAO_0000115 "A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001025" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "pressure" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001031 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001031" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "elasticity" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001043 obo:IAO_0000115 "A quality inhering in an entity by virtue of the bearer's propensity to resist an external stimulus." ; obo:RO_0002604 obo:PATO_0001046 ; oboInOwl:hasExactSynonym "susceptibility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001043" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim ; a owl:Class ; rdfs:label "susceptibility toward" ; rdfs:subClassOf obo:PATO_0000085 . obo:PATO_0001046 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus." ; obo:RO_0002604 obo:PATO_0001043 ; oboInOwl:hasExactSynonym "resistance" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001046" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "resistance to" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0001152 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's having susceptibilty toward an external stimulus." ; obo:RO_0002604 obo:PATO_0001153 ; oboInOwl:hasExactSynonym "susceptible" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001152" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "susceptible toward" ; rdfs:subClassOf obo:PATO_0001043 . obo:PATO_0001154 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width." ; obo:RO_0002604 obo:PATO_0002364 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001154" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "elongated" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001159 obo:IAO_0000115 "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001159" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "concentrated" ; rdfs:subClassOf obo:PATO_0000033 . obo:PATO_0001162 obo:IAO_0000115 "A concentration which is higher relative to the normal or average." ; obo:RO_0002604 obo:PATO_0001163 ; oboInOwl:hasExactSynonym "high concentration" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001162" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased concentration" ; rdfs:subClassOf obo:PATO_0001159, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001159 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001163 obo:IAO_0000115 "A concentration which is lower relative to the normal or average." ; obo:RO_0002604 obo:PATO_0001162 ; oboInOwl:hasExactSynonym "low concentration" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001163" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased concentration" ; rdfs:subClassOf obo:PATO_0001159, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001159 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001164 obo:IAO_0000115 "A physical quality which inheres in a bearer by virtue of the bearer's exhibiting density." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001164" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dense" ; rdfs:subClassOf obo:PATO_0001019 . obo:PATO_0001167 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired." ; obo:RO_0002604 obo:PATO_0001168 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001167" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "damaged" ; rdfs:subClassOf obo:PATO_0001020 . obo:PATO_0001171 obo:IAO_0000115 "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." ; obo:RO_0002604 obo:PATO_0001172 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001171" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "elastic" ; rdfs:subClassOf obo:PATO_0001031 . obo:PATO_0001178 obo:IAO_0000115 "A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus." ; oboInOwl:hasExactSynonym "resistant" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001178" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "resistant to" ; rdfs:subClassOf obo:PATO_0001046 . obo:PATO_0001190 obo:IAO_0000115 "A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001190" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "juvenile" ; rdfs:subClassOf obo:PATO_0000261 . obo:PATO_0001195 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001195" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "proximal to" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001201 obo:IAO_0000115 "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter Y." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001201" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "Y-shaped" ; rdfs:subClassOf obo:PATO_0001890 . obo:PATO_0001230 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's power or force." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001230" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "strength" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001236 obo:IAO_0000115 "A quality which inheres in an process." ; oboInOwl:hasAlternativeId "PATO:0001239", "PATO:0001240" ; oboInOwl:hasExactSynonym "quality of a process", "quality of occurrent", "quality of process", "relational quality of occurrent" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001236" ; a owl:Class ; rdfs:comment "See comments of relational quality of a physical entity." ; rdfs:label "process quality" ; rdfs:subClassOf obo:PATO_0000001 ; owl:disjointWith obo:PATO_0001241 . obo:PATO_0001241 obo:IAO_0000115 "A quality which inheres in a continuant." ; oboInOwl:hasAlternativeId "PATO:0001237", "PATO:0001238" ; oboInOwl:hasDbXref "snap:Quality" ; oboInOwl:hasExactSynonym "monadic quality of a continuant", "multiply inhering quality of a physical entity", "quality of a continuant", "quality of a single physical entity", "quality of an object", "quality of continuant" ; oboInOwl:hasNarrowSynonym "monadic quality of an object", "monadic quality of continuant" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001241" ; a owl:Class ; rdfs:comment "Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles." ; rdfs:label "physical object quality" ; rdfs:subClassOf obo:PATO_0000001 . obo:PATO_0001292 obo:IAO_0000115 "An EM radiation quality that is independent of the EM wavelength range." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001292" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "full-spectrum EM radiation quality" ; rdfs:subClassOf obo:PATO_0070060 . obo:PATO_0001294 obo:IAO_0000115 "A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001294" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "radiation reflective quality" ; rdfs:subClassOf obo:PATO_0001292 . obo:PATO_0001297 obo:IAO_0000115 "A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001297" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "reflectivity" ; rdfs:subClassOf obo:PATO_0001294 . obo:PATO_0001300 obo:IAO_0000115 "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001300" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "optical quality" ; rdfs:subClassOf obo:PATO_0070060 . obo:PATO_0001301 obo:IAO_0000115 "An optical quality that is the mixture, purity or pattern of wavelengths of light perceived by the observer." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001301" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "chromatic property" ; rdfs:subClassOf obo:PATO_0001300 . obo:PATO_0001303 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "variability of a physical quality" ; oboInOwl:id "PATO:0001303" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "variability" ; rdfs:subClassOf obo:PATO_0000001 . obo:PATO_0001309 obo:IAO_0000115 "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." ; oboInOwl:hasAlternativeId "PATO:0000081" ; oboInOwl:hasExactSynonym "period" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "time" ; oboInOwl:id "PATO:0001309" ; oboInOwl:inSubset pato:attribute_slim, pato:hpo_slim ; a owl:Class ; rdfs:label "duration" ; rdfs:subClassOf obo:PATO_0002062 . obo:PATO_0001333 obo:IAO_0000115 "A quality of a process which ends later than the natural end time." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001333" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "temporally extended" ; rdfs:subClassOf obo:PATO_0002304, obo:PATO_0002324, [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] . obo:PATO_0001334 obo:IAO_0000115 "A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001334" ; oboInOwl:inSubset pato:attribute_slim, pato:mpath_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "diameter" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0001354 obo:IAO_0000115 "A optical quality inhering in a bearer by virtue of the bearer's exhibiting low opacity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001354" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "translucent" ; rdfs:subClassOf obo:PATO_0000957 . obo:PATO_0001355 obo:IAO_0000115 "A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere." ; obo:RO_0002604 obo:PATO_0001857 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001355" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "convex" ; rdfs:subClassOf obo:PATO_0002005 . obo:PATO_0001362 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's disposition to being easily damaged or destroyed." ; obo:RO_0002604 obo:PATO_0001716 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001362" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "fragile" ; rdfs:subClassOf obo:PATO_0001662 . obo:PATO_0001374 obo:IAO_0000115 "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001374" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "ploidy" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001375 obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001375" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "haploid" ; rdfs:subClassOf obo:PATO_0001393 . obo:PATO_0001393 obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001393" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "euploid" ; rdfs:subClassOf obo:PATO_0001374 . obo:PATO_0001394 obo:IAO_0000115 "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001394" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:comment "The exact number may be one or two different from the 2n number and still be classified as diploidy (although with aneuploidy). Nearly all mammals are diploid organisms, although all individuals have some small fraction of cells that are polyploidy." ; rdfs:label "diploid" ; rdfs:subClassOf obo:PATO_0001393 . obo:PATO_0001396 obo:IAO_0000115 "A monadic quality of continuant that exists at the cellular level of organisation." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001396" ; a owl:Class ; rdfs:label "cellular quality" ; rdfs:subClassOf obo:PATO_0070044 . obo:PATO_0001397 obo:IAO_0000115 "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001397" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim ; a owl:Class ; rdfs:label "cellular potency" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001400 obo:IAO_0000115 "A cellular potency that is the capacity to produce only one differentiated cell type." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001400" ; oboInOwl:inSubset pato:cell_quality, pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:comment "Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells." ; rdfs:label "unipotent" ; rdfs:subClassOf obo:PATO_0001397 . obo:PATO_0001401 obo:IAO_0000115 "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001401" ; oboInOwl:inSubset pato:cell_quality, pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:comment "Less potent than multipotent, often thought of as precursor or progenitor cell status." ; rdfs:label "oligopotent" ; rdfs:subClassOf obo:PATO_0001397 . obo:PATO_0001402 obo:IAO_0000115 "A cellular potency that is the capacity to form multiple differentiated cell types." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001402" ; oboInOwl:inSubset pato:cell_quality, pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "multipotent" ; rdfs:subClassOf obo:PATO_0001397 . obo:PATO_0001404 obo:IAO_0000115 "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001404" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "nucleate quality" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001405 obo:IAO_0000115 "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001405" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "anucleate" ; rdfs:subClassOf obo:PATO_0001404 . obo:PATO_0001406 obo:IAO_0000115 "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001406" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "binucleate" ; rdfs:subClassOf obo:PATO_0001908 . obo:PATO_0001407 obo:IAO_0000115 "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001407" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "mononucleate" ; rdfs:subClassOf obo:PATO_0002505 . obo:PATO_0001408 obo:IAO_0000115 "A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001408" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "ciliatedness" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001409 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's resembling a long tapered rod." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001409" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "spindle-shaped" ; rdfs:subClassOf obo:PATO_0002007 . obo:PATO_0001410 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001410" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "striated" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001419 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001419" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "sharp" ; rdfs:subClassOf obo:PATO_0000944 . obo:PATO_0001434 obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's ability to produce new life or offspring." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001434" ; a owl:Class ; rdfs:label "reproductive quality" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0001435 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001435" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "attachment quality" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001439 obo:IAO_0000115 "A contractile quality inhering in a bearer by virtue of the bearer's elastic tension that facilitate response to stimuli." ; oboInOwl:hasAlternativeId "PATO:0001498" ; oboInOwl:hasExactSynonym "tone" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001439" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "TODO: we need a clearer differentium between this and contractility - or merge?" ; rdfs:label "tonicity" ; rdfs:subClassOf obo:PATO_0001579 . obo:PATO_0001442 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of whether the bearer includes all its components." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001442" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "wholeness" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001444 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's components no longer being in a single contiguous unit." ; oboInOwl:hasAlternativeId "PATO:0001443", "PATO:0001820" ; oboInOwl:hasExactSynonym "fragmented" ; oboInOwl:hasNarrowSynonym "fractured" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "cracked", "hemorrhaged", "split", "torn" ; oboInOwl:id "PATO:0001444" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "broken" ; rdfs:subClassOf obo:PATO_0001442 . obo:PATO_0001447 obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the bearer's being encrusted or impregnated with calcium carbonate (CHEBI:3311)." ; oboInOwl:hasExactSynonym "calcareous" ; oboInOwl:hasNarrowSynonym "calcification" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001447" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "calcified" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0001449 obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the bearer's cartilage quantities." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001449" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment "Cartilage is a type of dense connective tissue. It is composed of specialized cells called chondrocytes (CL:0000138) that produce a large amount of extracellular matrix composed of collagen fibers, abundant ground substance rich in proteoglycan, and elastin fibers." ; rdfs:label "cartilaginous" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0001450 obo:IAO_0000115 "A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid." ; oboInOwl:hasExactSynonym "edemic", "oedematous", "oedemic" ; oboInOwl:hasNarrowSynonym "edema", "oedema" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001450" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "edematous" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0001453 obo:IAO_0000115 "An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity." ; oboInOwl:hasExactSynonym "detached" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001453" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "detached from" ; rdfs:subClassOf obo:PATO_0001435 . obo:PATO_0001457 obo:IAO_0000115 "A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation." ; oboInOwl:hasExactSynonym "sensitivity of occurrent" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001457" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim ; a owl:Class ; rdfs:label "sensitivity of a process" ; rdfs:subClassOf obo:PATO_0002062 . obo:PATO_0001468 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the back or upper surface of an organism." ; oboInOwl:hasExactSynonym "curved posterior (human torso)", "curved superior (human head)" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001468" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "curved dorsal" ; rdfs:subClassOf obo:PATO_0000406 . obo:PATO_0001469 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the abdomen of an organism." ; oboInOwl:hasExactSynonym "curved anterior (human torso)", "curved inferior (human head)" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001469" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "curved ventral" ; rdfs:subClassOf obo:PATO_0000406 . obo:PATO_0001470 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's magnitude in respect to a related entity." ; oboInOwl:hasExactSynonym "proportion", "proportionality", "quotient", "ratio" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "rate" ; oboInOwl:id "PATO:0001470" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:comment "Examples: height to weight; brain size to body size. These could all be children of proportionality. Proportions can be measured as ratios. Some measures may be dimensionless. Not all ratios measure proportionality, eg m/s measures velocity which is not a proportion in the sense defined above, it is a quality in its own right." ; rdfs:label "proportionality to" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001472 obo:IAO_0000115 "A depth which is relatively low." ; obo:RO_0002604 obo:PATO_0001596 ; oboInOwl:hasAlternativeId "PATO:0001692" ; oboInOwl:hasExactSynonym "low depth", "shallow" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001472" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased depth" ; rdfs:subClassOf obo:PATO_0000587, obo:PATO_0001595 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001595 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001473 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's being present in two copies." ; oboInOwl:hasExactSynonym "doubled" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001473" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "duplicated" ; rdfs:subClassOf obo:PATO_0000470 . obo:PATO_0001474 obo:IAO_0000115 "An oriented quality inhering in a bearer by virtue of the bearer's axis being positioned forward." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001474" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "anteverted" ; rdfs:subClassOf obo:PATO_0000614 . obo:PATO_0001475 obo:IAO_0000115 "A position which is relatively high." ; obo:RO_0002604 obo:PATO_0001476 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "high position" ; oboInOwl:id "PATO:0001475" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased position" ; rdfs:subClassOf obo:PATO_0000140, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001476 obo:IAO_0000115 "A positional which is relatively low." ; obo:RO_0002604 obo:PATO_0001475 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "low position" ; oboInOwl:id "PATO:0001476" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased position" ; rdfs:subClassOf obo:PATO_0000140, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001477 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being drawn in or pulled back from any given point." ; oboInOwl:hasBroadSynonym "moved" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "retruded" ; oboInOwl:id "PATO:0001477" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "retracted" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001481 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001481" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "sloped" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001482 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's standing out or projecting beyond a surface or line." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001482" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "prominent" ; rdfs:subClassOf obo:PATO_0001598, obo:PATO_0015007 . obo:PATO_0001483 obo:IAO_0000115 "Absence of an organ, tissue or cell due to failure to develop from a primordium or precursor cell." ; oboInOwl:hasExactSynonym "aplasia", "undeveloped" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001483" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment "With aplasia, the primordium or precursor develops, but does not proceed in its development to a mature structure" ; rdfs:label "aplastic" ; rdfs:subClassOf obo:PATO_0002290, obo:PATO_0002291 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002290 obo:PATO_0002291 ) ] . obo:PATO_0001488 obo:IAO_0000115 "A cellular quality inhering in a cell by virtue of whether the bearer exhibits the ability to move spontaneously." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001488" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:comment "Term should be obsoleted and the GO term cellular motility should be used instead." ; rdfs:label "cellular motility" ; rdfs:subClassOf obo:PATO_0001396 . obo:PATO_0001495 obo:IAO_0000115 "A concave quality inhering in a bearer by virtue of the bearer's shape being a V-shaped cut." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "indented" ; oboInOwl:id "PATO:0001495" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "notched" ; rdfs:subClassOf obo:PATO_0001857 . obo:PATO_0001499 obo:IAO_0000115 "A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter)." ; oboInOwl:hasAlternativeId "PATO:0000408" ; oboInOwl:hasExactSynonym "globular" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "rotund" ; oboInOwl:id "PATO:0001499" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "spherical" ; rdfs:subClassOf obo:PATO_0001865, [ a owl:Restriction ; owl:onProperty obo:RO_0015011 ; owl:someValuesFrom obo:PATO_0000411 ] . obo:PATO_0001500 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end." ; oboInOwl:hasExactSynonym "taper" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001500" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "tapered" ; rdfs:subClassOf obo:PATO_0001419 . obo:PATO_0001501 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development." ; obo:RO_0002604 obo:PATO_0001701 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "underdeveloped" ; oboInOwl:id "PATO:0001501" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "immature" ; rdfs:subClassOf obo:PATO_0000261 . obo:PATO_0001505 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "discontiguous", "divided_from", "splitted from" ; oboInOwl:id "PATO:0001505" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "separated from" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001507 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001507" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "disrupted" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0001509 obo:IAO_0000115 "A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s)." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001509" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "functionality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001510 obo:IAO_0000115 "A functionality quality held by the bearer when the latter is able to perform a regular function(s)." ; obo:RO_0002604 obo:PATO_0001511 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001510" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "functional" ; rdfs:subClassOf obo:PATO_0001509 . obo:PATO_0001511 obo:IAO_0000115 "A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s)." ; obo:RO_0002604 obo:PATO_0001510 ; oboInOwl:hasAlternativeId "PATO:0001640" ; oboInOwl:hasExactSynonym "disfunctional", "functional failure" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "defective", "failure" ; oboInOwl:id "PATO:0001511" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "non-functional" ; rdfs:subClassOf obo:PATO_0001509 . obo:PATO_0001512 obo:IAO_0000115 "A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "dotted", "spotted", "stippled" ; oboInOwl:id "PATO:0001512" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "punctate" ; rdfs:subClassOf obo:PATO_0000330 . obo:PATO_0001543 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001543" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim ; a owl:Class ; rdfs:label "flexibility" ; rdfs:subClassOf obo:PATO_0001546 . obo:PATO_0001544 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking." ; obo:RO_0002604 obo:PATO_0001545 ; oboInOwl:hasExactSynonym "bendy" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001544" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "flexible" ; rdfs:subClassOf obo:PATO_0001543 . obo:PATO_0001545 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking." ; obo:RO_0002604 obo:PATO_0001544 ; oboInOwl:hasExactSynonym "stiff" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "stiffness" ; oboInOwl:id "PATO:0001545" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "inflexible" ; rdfs:subClassOf obo:PATO_0001543 . obo:PATO_0001546 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." ; oboInOwl:hasExactSynonym "solidity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001546" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "quality of a solid" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001547 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." ; oboInOwl:hasExactSynonym "gaseous" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001547" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "quality of a gas" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001548 obo:IAO_0000115 "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." ; oboInOwl:hasExactSynonym "liquidity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001548" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "quality of a liquid" ; rdfs:subClassOf obo:PATO_0002198 . obo:PATO_0001549 obo:IAO_0000115 "A sensitivity toward an external stimulus which is higher than normal/average." ; obo:RO_0002604 obo:PATO_0001550 ; oboInOwl:hasExactSynonym "high sensitivity toward", "increased sensitivity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001549" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased sensitivity toward" ; rdfs:subClassOf obo:PATO_0000516, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000516 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001550 obo:IAO_0000115 "A sensitivity toward an external stimulus which is lower than normal/average." ; obo:RO_0002604 obo:PATO_0001549 ; oboInOwl:hasExactSynonym "decreased sensitivity", "low sensitivity toward" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001550" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased sensitivity toward" ; rdfs:subClassOf obo:PATO_0000516, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000516 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001551 obo:IAO_0000115 "A sensitivity of a process which is higher than normal or average." ; obo:RO_0002604 obo:PATO_0001552 ; oboInOwl:hasExactSynonym "high sensitivity of occurrent", "increased sensitivity of occurrent" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001551" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased sensitivity of a process" ; rdfs:subClassOf obo:PATO_0001457, obo:PATO_0002304 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001457 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001552 obo:IAO_0000115 "A sensitivity of a process which is lower than normal or average." ; obo:RO_0002604 obo:PATO_0001551 ; oboInOwl:hasExactSynonym "decreased sensitivity of occurrent", "low sensitivity of occurrent" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001552" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased sensitivity of a process" ; rdfs:subClassOf obo:PATO_0001457, obo:PATO_0002302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001457 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001555 obo:IAO_0000115 "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." ; oboInOwl:hasDbXref "OBO_REL:has_part" ; oboInOwl:hasExactSynonym "extra or missing physical or functional parts", "has or lacks parts of type", "mereological quality", "number of" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "cardinality", "number" ; oboInOwl:id "PATO:0001555" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "has number of" ; rdfs:subClassOf obo:PATO_0001241, [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0000070 ] . obo:PATO_0001558 obo:IAO_0000115 "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001558" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "lacking processual parts" ; rdfs:subClassOf obo:PATO_0001564, [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0000462 ] . obo:PATO_0001559 obo:IAO_0000115 "A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s)." ; oboInOwl:hasExactSynonym "having supernumerary functions" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001559" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "having extra function" ; rdfs:subClassOf obo:PATO_0001509, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001509 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001561 obo:IAO_0000115 "A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts." ; oboInOwl:hasExactSynonym "having supernumerary processual parts" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001561" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "having extra processual parts" ; rdfs:subClassOf obo:PATO_0001564 . obo:PATO_0001562 obo:IAO_0000115 "A mass which is lower than normal or average." ; obo:RO_0002604 obo:PATO_0001563 ; oboInOwl:hasAlternativeId "PATO:0000579" ; oboInOwl:hasExactSynonym "low mass", "small mass" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001562" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased mass" ; rdfs:subClassOf obo:PATO_0000125, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001563 obo:IAO_0000115 "A mass which is higher than normal or average." ; obo:RO_0002604 obo:PATO_0001562 ; oboInOwl:hasAlternativeId "PATO:0000578" ; oboInOwl:hasExactSynonym "high mass", "large mass" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001563" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased mass" ; rdfs:subClassOf obo:PATO_0000125, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001564 obo:IAO_0000115 "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001564" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:label "extra or missing processual parts" ; rdfs:subClassOf obo:PATO_0001236 . obo:PATO_0001571 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001571" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dilated" ; rdfs:subClassOf obo:PATO_0000586 . obo:PATO_0001575 obo:IAO_0000115 "A pressure which is relatively low." ; obo:RO_0002604 obo:PATO_0001576 ; oboInOwl:hasExactSynonym "low pressure" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001575" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased pressure" ; rdfs:subClassOf obo:PATO_0001025, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001025 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001576 obo:IAO_0000115 "A pressure which is relatively high." ; obo:RO_0002604 obo:PATO_0001575 ; oboInOwl:hasExactSynonym "high pressure" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001576" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased pressure" ; rdfs:subClassOf obo:PATO_0001025, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001025 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001579 obo:IAO_0000115 "A physical quality that is the ability to contract or shrink." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001579" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "contractility" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001580 obo:IAO_0000115 "A contractility which is relatively high." ; obo:RO_0002604 obo:PATO_0001581 ; oboInOwl:hasExactSynonym "high contractility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001580" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased contractility" ; rdfs:subClassOf obo:PATO_0001690, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001690 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001581 obo:IAO_0000115 "A contractility which is relatively low." ; obo:RO_0002604 obo:PATO_0001580 ; oboInOwl:hasExactSynonym "low contractility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001581" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased contractility" ; rdfs:subClassOf obo:PATO_0001690, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001690 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001590 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's coinciding spatially, partially or wholly with another entity." ; oboInOwl:hasExactSynonym "overlap" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001590" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "overlap with" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001591 obo:IAO_0000115 "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001591" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "curvature" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001592 obo:IAO_0000115 "A curvature which is relatively high." ; obo:RO_0002604 obo:PATO_0001593 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001592" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased curvature" ; rdfs:subClassOf obo:PATO_0000406, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001593 obo:IAO_0000115 "A curvature which is relatively low." ; obo:RO_0002604 obo:PATO_0001592 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001593" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased curvature" ; rdfs:subClassOf obo:PATO_0000406, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001594 obo:IAO_0000115 "A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001594" ; oboInOwl:inSubset pato:cell_quality ; a owl:Class ; rdfs:label "arched" ; rdfs:subClassOf obo:PATO_0001857 . obo:PATO_0001595 obo:IAO_0000115 "A 1-D extent quality inhering in a bearer by virtue of the bearer's downward or backward or inward dimension." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001595" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "depth" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0001596 obo:IAO_0000115 "A depth quality which is relatively high." ; obo:RO_0002604 obo:PATO_0001472 ; oboInOwl:hasAlternativeId "PATO:0001666" ; oboInOwl:hasExactSynonym "deep" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001596" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased depth" ; rdfs:subClassOf obo:PATO_0000586, obo:PATO_0001595 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001595 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001597 obo:IAO_0000115 "An oriented quality inhering in a bearer by virtue of the bearer's being turned outward in placement." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001597" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "everted" ; rdfs:subClassOf obo:PATO_0000614 . obo:PATO_0001598 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary." ; oboInOwl:hasAlternativeId "PATO:0001644" ; oboInOwl:hasExactSynonym "protruding", "relational protruding quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001598" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "protruding" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001599 obo:IAO_0000115 "An oriented quality inhering in a bearer by virtue of the bearer's being relocated around an axis." ; oboInOwl:hasExactSynonym "rotation" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001599" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "rotated" ; rdfs:subClassOf obo:PATO_0000614 . obo:PATO_0001600 obo:IAO_0000115 "A rotation quality inhering in a bearer by virtue of being rotated towards the rear of organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001600" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "posteriorly rotated" ; rdfs:subClassOf obo:PATO_0001599 . obo:PATO_0001602 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "expanded" ; oboInOwl:id "PATO:0001602" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "distended" ; rdfs:subClassOf obo:PATO_0000586 . obo:PATO_0001603 obo:IAO_0000115 "A life span which is relatively high." ; obo:RO_0002604 obo:PATO_0001604 ; oboInOwl:hasExactSynonym "high life span" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001603" ; a owl:Class ; rdfs:label "increased life span" ; rdfs:subClassOf obo:PATO_0000050, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000050 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001604 obo:IAO_0000115 "A life span which is relatively low." ; obo:RO_0002604 obo:PATO_0001603 ; oboInOwl:hasExactSynonym "low life span" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001604" ; a owl:Class ; rdfs:label "decreased life span" ; rdfs:subClassOf obo:PATO_0000050, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000050 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001608 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's being marked by, consisting of, or diversified with patches." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001608" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "patchy" ; rdfs:subClassOf obo:PATO_0000330 . obo:PATO_0001609 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's being scattered; spread irregularly, and at a distance from each other." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001609" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "sparse" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0001617 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "disfigured", "distorted" ; oboInOwl:id "PATO:0001617" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "deformed" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0001618 obo:IAO_0000115 "A tonicity which is relatively high." ; obo:RO_0002604 obo:PATO_0001619 ; oboInOwl:hasExactSynonym "high tonicity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001618" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased tonicity" ; rdfs:subClassOf obo:PATO_0001439, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001439 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001619 obo:IAO_0000115 "A tonicity which is relatively low." ; obo:RO_0002604 obo:PATO_0001618 ; oboInOwl:hasExactSynonym "low tonicity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001619" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased tonicity" ; rdfs:subClassOf obo:PATO_0001439, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001439 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001623 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of a part or parts of the bearer's being decreased in size due to reduction in tissue mass through wasting." ; oboInOwl:hasExactSynonym "atrophic" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001623" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "atrophied" ; rdfs:subClassOf obo:PATO_0000587 . obo:PATO_0001624 obo:IAO_0000115 "A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s)." ; obo:RO_0002604 obo:PATO_0001625 ; oboInOwl:hasAlternativeId "PATO:0001556", "PATO:0001568", "PATO:0001641", "PATO:0001642" ; oboInOwl:hasBroadSynonym "dysfunction", "dysfunctional" ; oboInOwl:hasExactSynonym "having decreased function", "lacks function of type", "low functionality", "partial functionality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "impaired" ; oboInOwl:id "PATO:0001624" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased functionality" ; rdfs:subClassOf obo:PATO_0001510, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001510 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001625 obo:IAO_0000115 "A functional quality held by the bearer when the latter exhibits increased ability to perform a regular function(s)." ; obo:RO_0002604 obo:PATO_0001624 ; oboInOwl:hasExactSynonym "high functionality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001625" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased functionality" ; rdfs:subClassOf obo:PATO_0001510, obo:PATO_0001559 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001510 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001626 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of whether the bearer has enough functionality." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "adequacy" ; oboInOwl:id "PATO:0001626" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "This term and children should probably be obsoleted." ; rdfs:label "sufficiency" ; rdfs:subClassOf obo:PATO_0001509 . obo:PATO_0001628 obo:IAO_0000115 "A wholeness quality inhering in a bearer by virtue of the bearer's lacks enough functionality." ; obo:RO_0002604 obo:PATO_0001627 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "inadequate" ; oboInOwl:id "PATO:0001628" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "insufficient" ; rdfs:subClassOf obo:PATO_0001626 . obo:PATO_0001645 obo:IAO_0000115 "A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary into the surface or boundary of another entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001645" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "protruding into" ; rdfs:subClassOf obo:PATO_0001598 . obo:PATO_0001646 obo:IAO_0000115 "A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary and outwards in relation to the physical space occupied by another entity." ; oboInOwl:hasExactSynonym "extruding from" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "exits through", "exposed" ; oboInOwl:id "PATO:0001646" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "protruding out of" ; rdfs:subClassOf obo:PATO_0001598 . obo:PATO_0001648 obo:IAO_0000115 "An 1-D extent quality which is equal to the length of the closed curve of a circle." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001648" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "circumference" ; rdfs:subClassOf obo:PATO_0001711 . obo:PATO_0001649 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the side." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001649" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "curved lateral" ; rdfs:subClassOf obo:PATO_0000406 . obo:PATO_0001650 obo:IAO_0000115 "A resistance to a stimulus which is relatively high." ; obo:RO_0002604 obo:PATO_0001651 ; oboInOwl:hasExactSynonym "high resistance to", "increased resistance" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001650" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased resistance to" ; rdfs:subClassOf obo:PATO_0001178, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001178 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001651 obo:IAO_0000115 "A resistance to a stimulus which is relatively low." ; obo:RO_0002604 obo:PATO_0001650 ; oboInOwl:hasExactSynonym "decreased resistance", "low resistance to" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001651" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased resistance to" ; rdfs:subClassOf obo:PATO_0001178, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001178 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001652 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001652" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "alignment" ; rdfs:subClassOf obo:PATO_0000140, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PATO_0000133 ] . obo:PATO_0001654 obo:IAO_0000115 "An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning with respect to an additional entity." ; obo:RO_0002604 obo:PATO_0001653 ; oboInOwl:hasExactSynonym "misaligned", "unaligned with" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001654" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "misaligned with" ; rdfs:subClassOf obo:PATO_0001652 . obo:PATO_0001662 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's disposition to being damaged or destroyed." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001662" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "fragility" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001669 obo:IAO_0000115 "A susceptibility toward an external stimulus which is higher than normal/average." ; obo:RO_0002604 obo:PATO_0001670 ; oboInOwl:hasExactSynonym "high susceptibility toward", "increased susceptibility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001669" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased susceptibility toward" ; rdfs:subClassOf obo:PATO_0001152, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001152 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001670 obo:IAO_0000115 "A susceptibility toward an external stimulus which is lower than normal/average." ; obo:RO_0002604 obo:PATO_0001669 ; oboInOwl:hasExactSynonym "decreased susceptibility", "low susceptibility toward" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001670" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased susceptibility toward" ; rdfs:subClassOf obo:PATO_0001152, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001152 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001673 obo:IAO_0000115 "Structure quality that is the presence of at least one sac-like closed membranous structure containing one or more liquid or solid organism substances." ; oboInOwl:hasNarrowSynonym "cysts" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001673" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:comment "Cystic is an abnormal condition." ; rdfs:label "cystic" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0001690 obo:IAO_0000115 "A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted." ; obo:RO_0002604 obo:PATO_0001691 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001690" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:comment "This refers to the disposition of the bearer." ; rdfs:label "contractile" ; rdfs:subClassOf obo:PATO_0001579 . obo:PATO_0001693 obo:IAO_0000115 "A viscosity which relatively high." ; obo:RO_0002604 obo:PATO_0001694 ; oboInOwl:hasExactSynonym "high viscosity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001693" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased viscosity" ; rdfs:subClassOf obo:PATO_0000998, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000998 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001694 obo:IAO_0000115 "A viscosity which relatively low." ; obo:RO_0002604 obo:PATO_0001693 ; oboInOwl:hasExactSynonym "low viscosity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001694" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased viscosity" ; rdfs:subClassOf obo:PATO_0000998, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000998 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001697 obo:IAO_0000115 "A photosensitivity which is relatively low." ; obo:RO_0002604 obo:PATO_0001698 ; oboInOwl:hasExactSynonym "low photosensitivity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001697" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased photosensitivity" ; rdfs:subClassOf obo:PATO_0000547, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000547 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001698 obo:IAO_0000115 "A photosensitivity which is relatively high." ; obo:RO_0002604 obo:PATO_0001697 ; oboInOwl:hasExactSynonym "high photosensitivity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001698" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased photosensitivity" ; rdfs:subClassOf obo:PATO_0000547, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000547 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001707 obo:IAO_0000115 "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting marked activity." ; obo:RO_0002604 obo:PATO_0001706 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001707" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "behavioural active" ; rdfs:subClassOf obo:PATO_0002265 . obo:PATO_0001708 obo:IAO_0000115 "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." ; oboInOwl:hasExactSynonym "1-D size" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001708" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "1-D extent" ; rdfs:subClassOf obo:PATO_0000117 . obo:PATO_0001710 obo:IAO_0000115 "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." ; oboInOwl:hasExactSynonym "3D size" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001710" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "3-D extent" ; rdfs:subClassOf obo:PATO_0000117 . obo:PATO_0001711 obo:IAO_0000115 "An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001711" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "perimeter" ; rdfs:subClassOf obo:PATO_0001708 . obo:PATO_0001712 obo:IAO_0000115 "A perimeter which is relatively high." ; obo:RO_0002604 obo:PATO_0001713 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001712" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased perimeter" ; rdfs:subClassOf obo:PATO_0000573, obo:PATO_0001711 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001711 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001713 obo:IAO_0000115 "A perimeter which is relatively low." ; obo:RO_0002604 obo:PATO_0001712 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001713" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased perimeter" ; rdfs:subClassOf obo:PATO_0000574, obo:PATO_0001711 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001711 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001714 obo:IAO_0000115 "A diameter which is relatively large." ; obo:RO_0002604 obo:PATO_0001715 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001714" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased diameter" ; rdfs:subClassOf obo:PATO_0001334 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001334 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001715 obo:IAO_0000115 "A diameter which is relatively small." ; obo:RO_0002604 obo:PATO_0001714 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001715" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased diameter" ; rdfs:subClassOf obo:PATO_0001334 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001334 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001727 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's prevailing tendency, mood, or inclination." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "tendency" ; oboInOwl:id "PATO:0001727" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim ; a owl:Class ; rdfs:label "disposition" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001735 obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids." ; oboInOwl:hasExactSynonym "liquid" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001735" ; a owl:Class ; rdfs:label "liquid configuration" ; rdfs:subClassOf obo:PATO_0001548 . obo:PATO_0001748 obo:IAO_0000115 "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001748" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "invaginated" ; rdfs:subClassOf obo:PATO_0001857 . obo:PATO_0001776 obo:IAO_0000115 "A flexibility which is relatively high." ; obo:RO_0002604 obo:PATO_0001777 ; oboInOwl:hasExactSynonym "high flexibility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001776" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased flexibility" ; rdfs:subClassOf obo:PATO_0001544, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001544 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001777 obo:IAO_0000115 "A flexibility which is relatively low." ; obo:RO_0002604 obo:PATO_0001776 ; oboInOwl:hasExactSynonym "low flexibility" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001777" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased flexibility" ; rdfs:subClassOf obo:PATO_0001544, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001544 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001778 obo:IAO_0000115 "A strength which is relatively high." ; obo:RO_0002604 obo:PATO_0001779 ; oboInOwl:hasExactSynonym "high strength" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001778" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased strength" ; rdfs:subClassOf obo:PATO_0001230, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001230 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001779 obo:IAO_0000115 "A strength which is relatively low." ; obo:RO_0002604 obo:PATO_0001778 ; oboInOwl:hasExactSynonym "weak" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001779" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased strength" ; rdfs:subClassOf obo:PATO_0001230, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001230 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001780 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of the bearer's being abnormally developed, usually due to malnutrition." ; oboInOwl:hasExactSynonym "dystrophied" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "dystrophy" ; oboInOwl:id "PATO:0001780" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dystrophic" ; rdfs:subClassOf obo:PATO_0000587 . obo:PATO_0001782 obo:IAO_0000115 "An intensity which is relatively high." ; obo:RO_0002604 obo:PATO_0001783 ; oboInOwl:hasExactSynonym "high intensity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001782" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased intensity" ; rdfs:subClassOf obo:PATO_0000049, obo:PATO_0002300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000049 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001783 obo:IAO_0000115 "An intensity which is relatively low." ; obo:RO_0002604 obo:PATO_0001782 ; oboInOwl:hasExactSynonym "low intensity" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001783" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased intensity" ; rdfs:subClassOf obo:PATO_0000049, obo:PATO_0002301 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000049 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001784 obo:IAO_0000115 "A branched quality inhering in a bearer by virtue of the bearer's being divided into two branches." ; oboInOwl:hasAlternativeId "PATO:0001572" ; oboInOwl:hasExactSynonym "bifid" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "forked" ; oboInOwl:id "PATO:0001784" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "bifurcated" ; rdfs:subClassOf obo:PATO_0000402, obo:PATO_0001786 . obo:PATO_0001785 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved outward." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001785" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:comment "TODO: obsolete, definition too ambiguous." ; rdfs:label "splayed" ; rdfs:subClassOf obo:PATO_0000406 . obo:PATO_0001786 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions." ; oboInOwl:hasExactSynonym "clefted" ; oboInOwl:hasNarrowSynonym "septate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "divided", "forked", "subdivided" ; oboInOwl:id "PATO:0001786" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "split" ; rdfs:subClassOf obo:PATO_0000052 ; owl:disjointWith obo:PATO_0002034 . obo:PATO_0001787 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001787" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "rotational curvature" ; rdfs:subClassOf obo:PATO_0001591 . obo:PATO_0001788 obo:IAO_0000115 "A density which is higher relative to the normal or average." ; obo:RO_0002604 obo:PATO_0001790 ; oboInOwl:hasExactSynonym "high density" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001788" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased mass density" ; rdfs:subClassOf obo:PATO_0001164, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001164 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001790 obo:IAO_0000115 "A density which is lower relative to the normal or average." ; obo:RO_0002604 obo:PATO_0001788 ; oboInOwl:hasExactSynonym "low density" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001790" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased mass density" ; rdfs:subClassOf obo:PATO_0001164, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001164 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001793 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001793" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "right side of" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001794 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001794" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "coiling" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001795 obo:IAO_0000115 "A coiling which is relatively high." ; obo:RO_0002604 obo:PATO_0001796 ; oboInOwl:hasExactSynonym "high coiling" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001795" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "increased coiling" ; rdfs:subClassOf obo:PATO_0000404, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000404 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001796 obo:IAO_0000115 "A coiling which is relatively low." ; obo:RO_0002604 obo:PATO_0001795 ; oboInOwl:hasExactSynonym "low coiling" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001796" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "decreased coiling" ; rdfs:subClassOf obo:PATO_0000404, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000404 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001800 obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the quantities or relative ratios of water of the inhering entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001800" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "water composition" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0001801 obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the reduction in amount of water the bearer contains." ; oboInOwl:hasExactSynonym "dehydrated" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "dry" ; oboInOwl:id "PATO:0001801" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased water composition" ; rdfs:subClassOf obo:PATO_0001800, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001800 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001802 obo:IAO_0000115 "A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001802" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "loose" ; rdfs:subClassOf obo:PATO_0000330 . obo:PATO_0001810 obo:IAO_0000115 "A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by one or more creases in a normally smooth surface." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001810" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "wrinkled" ; rdfs:subClassOf obo:PATO_0002255 . obo:PATO_0001815 obo:IAO_0000115 "A strength quality inhering in a bearer by virtue of the bearer's disposition to lose strength." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001815" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "fatigability" ; rdfs:subClassOf obo:PATO_0001230 . obo:PATO_0001816 obo:IAO_0000115 "A fatigability which is relatively high." ; obo:RO_0002604 obo:PATO_0001817 ; oboInOwl:hasExactSynonym "high fatigability" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001816" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased fatigability" ; rdfs:subClassOf obo:PATO_0001779, obo:PATO_0001815 . obo:PATO_0001818 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time." ; obo:RO_0002604 obo:PATO_0002026 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001818" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "progressive" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0001819 obo:IAO_0000115 "A morphological quality inhering in a bearer by virtue of the bearer's absence or closure of a normal body orifice or tubular passage." ; oboInOwl:hasExactSynonym "atresia" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001819" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "atretic" ; rdfs:subClassOf obo:PATO_0000608 . obo:PATO_0001821 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's having no opening." ; obo:RO_0002604 obo:PATO_0002112 ; oboInOwl:hasExactSynonym "unperforated" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001821" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "imperforate" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0001822 obo:IAO_0000115 "A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001822" ; oboInOwl:inSubset pato:attribute_slim, pato:mpath_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "wetness" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0001824 obo:IAO_0000115 "A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid." ; obo:RO_0002604 obo:PATO_0001823 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001824" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dry" ; rdfs:subClassOf obo:PATO_0001822 . obo:PATO_0001827 obo:IAO_0000115 "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001827" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "pseudohermaphrodite" ; rdfs:subClassOf obo:PATO_0001894 . obo:PATO_0001828 obo:IAO_0000115 "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001828" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "male pseudohermaphrodite" ; rdfs:subClassOf obo:PATO_0001827 . obo:PATO_0001829 obo:IAO_0000115 "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001829" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "female pseudohermaphrodite" ; rdfs:subClassOf obo:PATO_0001827 . obo:PATO_0001845 obo:IAO_0000115 "A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm lacking pattern." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001845" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "irregular rhythm" ; rdfs:subClassOf obo:PATO_0000078 . obo:PATO_0001847 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically." ; oboInOwl:hasAlternativeId "PATO:0001837" ; oboInOwl:hasExactSynonym "stenosis", "stenotic", "stricture" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001847" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "constricted" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001848 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved asymmetrically." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001848" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "asymmetrically curved" ; rdfs:subClassOf obo:PATO_0000406 . obo:PATO_0001850 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's being fibrous tissue that replaces normal tissue destroyed by injury or disease." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001850" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "scarred" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0001851 obo:IAO_0000115 "A structure quality inhering in a bearer by virtue of the bearer's exhibiting transient abnormal enlargement, not due to cell proliferation." ; oboInOwl:hasNarrowSynonym "swelling" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001851" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "swollen" ; rdfs:subClassOf obo:PATO_0000141, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PATO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PATO_0001598 ] . obo:PATO_0001852 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position." ; oboInOwl:hasAlternativeId "PATO:0001479", "PATO:0002158", "PATO:0002159" ; oboInOwl:hasExactSynonym "dislocation", "luxated", "luxation", "relational dislocated quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001852" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "dislocated" ; rdfs:subClassOf obo:PATO_0002181 . obo:PATO_0001854 obo:IAO_0000115 "A spatial pattern inhering in a bearer by virtue of the bearer's being situated at right angles to the horizon." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001854" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "vertical" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0001855 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being in the plane of the horizon." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001855" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "horizontal" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0001857 obo:IAO_0000115 "A shape quality in a bearer by virtue of the bearer's curving inward." ; obo:RO_0002604 obo:PATO_0001355 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001857" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "concave" ; rdfs:subClassOf obo:PATO_0002005 . obo:PATO_0001863 obo:IAO_0000115 "A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration." ; obo:RO_0002604 obo:PATO_0000389 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001863" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "chronic" ; rdfs:subClassOf obo:PATO_0001309 . obo:PATO_0001865 obo:IAO_0000115 "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids." ; oboInOwl:hasAlternativeId "PATO:0001864" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "sphericality" ; oboInOwl:id "PATO:0001865" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "spheroid" ; rdfs:subClassOf obo:PATO_0002007 . obo:PATO_0001869 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001869" ; oboInOwl:inSubset pato:abnormal_slim, pato:value_slim ; a owl:Class ; rdfs:label "pathological" ; rdfs:subClassOf obo:PATO_0000460 . obo:PATO_0001872 obo:IAO_0000115 "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section)." ; oboInOwl:hasExactSynonym "cuboidal" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "block-like" ; oboInOwl:id "PATO:0001872" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "cuboid" ; rdfs:subClassOf obo:PATO_0002007, [ a owl:Restriction ; owl:onProperty obo:RO_0015011 ; owl:someValuesFrom obo:PATO_0000413 ] . obo:PATO_0001873 obo:IAO_0000115 "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." ; oboInOwl:hasAlternativeId "PATO:0001203" ; oboInOwl:hasExactSynonym "rod-like", "rod-shaped" ; oboInOwl:hasNarrowSynonym "tubulate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001873" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "cylindrical" ; rdfs:subClassOf obo:PATO_0002007, [ a owl:Restriction ; owl:onProperty obo:RO_0015011 ; owl:someValuesFrom obo:PATO_0000411 ] . obo:PATO_0001874 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter." ; oboInOwl:hasExactSynonym "disc-shaped", "disk-shaped" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001874" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "discoid" ; rdfs:subClassOf obo:PATO_0001873 . obo:PATO_0001875 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having three angles." ; oboInOwl:hasExactSynonym "deltoid" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "delta shaped", "triangle", "triangle-shaped" ; oboInOwl:id "PATO:0001875" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "triangular" ; rdfs:subClassOf obo:PATO_0002006 . obo:PATO_0001876 obo:IAO_0000115 "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two parts, roughly spherical and of equal size, connected by a bar." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001876" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "dumbbell-shaped" ; rdfs:subClassOf obo:PATO_0002008 . obo:PATO_0001878 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped." ; oboInOwl:hasExactSynonym "S-shaped", "sigmoidal" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001878" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "sigmoid" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001879 obo:IAO_0000115 "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter U." ; oboInOwl:hasExactSynonym "horseshoe shaped" ; oboInOwl:hasNarrowSynonym "horseshoe" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001879" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "U-shaped" ; rdfs:subClassOf obo:PATO_0002008 . obo:PATO_0001883 obo:IAO_0000115 "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's gradually becoming thicker towards the end." ; oboInOwl:hasAlternativeId "PATO:0001797" ; oboInOwl:hasExactSynonym "club-like", "club-shaped", "clubbed" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001883" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "clavate" ; rdfs:subClassOf obo:PATO_0002008 . obo:PATO_0001890 obo:IAO_0000115 "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being divided into three branches." ; oboInOwl:hasExactSynonym "trifurcate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001890" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "tripartite" ; rdfs:subClassOf obo:PATO_0000402, obo:PATO_0002008 . obo:PATO_0001891 obo:IAO_0000115 "A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; egg-shaped." ; oboInOwl:hasExactSynonym "egg-shaped", "oval", "ovoid" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "eccentric" ; oboInOwl:id "PATO:0001891" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "ovate" ; rdfs:subClassOf obo:PATO_0001865, [ a owl:Restriction ; owl:onProperty obo:RO_0015011 ; owl:someValuesFrom obo:PATO_0000946 ] . obo:PATO_0001894 obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001894" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "phenotypic sex" ; rdfs:subClassOf obo:PATO_0000047 . obo:PATO_0001898 obo:IAO_0000115 "A circumference which is relatively high." ; obo:RO_0002604 obo:PATO_0001899 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001898" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased circumference" ; rdfs:subClassOf obo:PATO_0001648, obo:PATO_0001712 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001648 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001899 obo:IAO_0000115 "A circumference which is relatively low." ; obo:RO_0002604 obo:PATO_0001898 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001899" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased circumference" ; rdfs:subClassOf obo:PATO_0001648, obo:PATO_0001713 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001648 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001908 obo:IAO_0000115 "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001908" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "multinucleate" ; rdfs:subClassOf obo:PATO_0002505 . obo:PATO_0001910 obo:IAO_0000115 "A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001910" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "folded" ; rdfs:subClassOf obo:PATO_0001925 . obo:PATO_0001919 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the back or upper surface of an organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001919" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mislocalised dorsally" ; rdfs:subClassOf obo:PATO_0000628 . obo:PATO_0001921 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the front of an organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001921" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mislocalised anteriorly" ; rdfs:subClassOf obo:PATO_0000628 . obo:PATO_0001922 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the rear of an organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001922" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mislocalised posteriorly" ; rdfs:subClassOf obo:PATO_0000628 . obo:PATO_0001923 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the side of an organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001923" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mislocalised laterally" ; rdfs:subClassOf obo:PATO_0000628 . obo:PATO_0001925 obo:IAO_0000115 "A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001925" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved." ; rdfs:label "surface feature shape" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001928 obo:IAO_0000115 "A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer." ; oboInOwl:hasNarrowSynonym "blistering" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001928" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "blistered" ; rdfs:subClassOf obo:PATO_0000150 . obo:PATO_0001937 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being oblong, with the lower end very much attenuated." ; oboInOwl:hasExactSynonym "spathulate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001937" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "spatulate" ; rdfs:subClassOf obo:PATO_0000946 . obo:PATO_0001938 obo:IAO_0000115 "A spheroid quality inhering in a bearer by virtue of the bearer's being oval and a little angular in the middle." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001938" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "rhomboid" ; rdfs:subClassOf obo:PATO_0002317 . obo:PATO_0001940 obo:IAO_0000115 "A size quality inhering in a bearer by virtue of the bearer's being many folds greater relative to the normal average." ; oboInOwl:hasExactSynonym "giant" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001940" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "gigantic" ; rdfs:subClassOf obo:PATO_0000586 . obo:PATO_0001948 obo:IAO_0000115 "A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by two or more parallel channels." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "fluted" ; oboInOwl:id "PATO:0001948" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "furrowed" ; rdfs:subClassOf obo:PATO_0002255 . obo:PATO_0001955 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base." ; oboInOwl:hasExactSynonym "wedge-shaped" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001955" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "cuneate" ; rdfs:subClassOf obo:PATO_0001875 . obo:PATO_0001956 obo:IAO_0000115 "A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001956" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "variability of size" ; rdfs:subClassOf obo:PATO_0001303, [ a owl:Restriction ; owl:onProperty obo:RO_0002503 ; owl:someValuesFrom obo:PATO_0000117 ] . obo:PATO_0001957 obo:IAO_0000115 "A variability of size which is relatively low." ; obo:RO_0002604 obo:PATO_0001958 ; oboInOwl:hasExactSynonym "low variability of size" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001957" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased variability of size" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001956 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001958 obo:IAO_0000115 "A variability of size which is relatively high." ; obo:RO_0002604 obo:PATO_0001957 ; oboInOwl:hasExactSynonym "high variability of size" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001958" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased variability of size" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001956 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001973 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being tapering gradually into a rigid point." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001973" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "cuspidate" ; rdfs:subClassOf obo:PATO_0001500 . obo:PATO_0001977 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having at least one salient angle on the margin." ; oboInOwl:hasExactSynonym "angulate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001977" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "angular" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0001987 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." ; oboInOwl:hasExactSynonym "sacular" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001987" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "saccular" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0001988 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001988" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "quadrangular" ; rdfs:subClassOf obo:PATO_0002006 . obo:PATO_0001992 obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001992" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "cellularity" ; rdfs:subClassOf obo:PATO_0001995 . obo:PATO_0001993 obo:IAO_0000115 "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001993" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "multicellular" ; rdfs:subClassOf obo:PATO_0001992 . obo:PATO_0001995 obo:IAO_0000115 "A quality that inheres in an entire organism or part of an organism." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001995" ; a owl:Class ; rdfs:label "organismal quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0001997 obo:IAO_0000115 "An amount which is relatively low." ; obo:RO_0002604 obo:PATO_0000470 ; oboInOwl:hasAlternativeId "PATO:0000419", "PATO:0000468" ; oboInOwl:hasExactSynonym "decreased number", "present in fewer numbers in organism" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "decreased", "reduced", "subnumerary" ; oboInOwl:id "PATO:0001997" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased amount" ; rdfs:subClassOf obo:PATO_0000467, obo:PATO_0002301 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000070 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0001999 obo:IAO_0000115 "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." ; oboInOwl:hasExactSynonym "loss of" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0001999" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:label "lacks parts or has fewer parts of type" ; rdfs:subClassOf obo:PATO_0002083 . obo:PATO_0002000 obo:IAO_0000115 "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." ; oboInOwl:hasAlternativeId "PATO:0001557" ; oboInOwl:hasDbXref "OBO_REL:lacks_part" ; oboInOwl:hasExactSynonym "lacks all physical parts of type" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002000" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:comment "Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2." ; rdfs:label "lacks all parts of type" ; rdfs:subClassOf obo:PATO_0001999, [ a owl:Restriction ; owl:onProperty obo:RO_0015012 ; owl:someValuesFrom obo:PATO_0000462 ] . obo:PATO_0002001 obo:IAO_0000115 "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." ; obo:RO_0002604 obo:PATO_0002002 ; oboInOwl:hasAlternativeId "PATO:0001569" ; oboInOwl:hasExactSynonym "decreased number of", "has decreased number of", "has fewer physical parts of type" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002001" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:comment "Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type." ; rdfs:label "has fewer parts of type" ; rdfs:subClassOf obo:PATO_0001999, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001999 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002002 obo:IAO_0000115 "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." ; obo:RO_0002604 obo:PATO_0002001 ; oboInOwl:hasAlternativeId "PATO:0001560" ; oboInOwl:hasExactSynonym "has extra parts of", "has increased number of", "having extra physical parts", "having supernumerary physical parts", "increased number of" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002002" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:comment "In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q= E2=finger." ; rdfs:label "has extra parts of type" ; rdfs:subClassOf obo:PATO_0002083, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002083 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002005 obo:IAO_0000115 "Surface shape that refers to the inward or outward curvature of the surface." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002005" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "concavity" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002006 obo:IAO_0000115 "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "2-D projection", "cross-sectional" ; oboInOwl:id "PATO:0002006" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "2-D shape" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002007 obo:IAO_0000115 "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." ; obo:RO_0002604 obo:PATO_0002008 ; oboInOwl:hasDbXref "Image:http://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002007" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:comment "Use this term or an is_a child of this term when the entire shape of the object is known." ; rdfs:label "convex 3-D shape" ; rdfs:subClassOf obo:PATO_0002266, [ a owl:Restriction ; owl:onProperty obo:RO_0015011 ; owl:someValuesFrom obo:PATO_0002006 ] . obo:PATO_0002008 obo:IAO_0000115 "A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave." ; obo:RO_0002604 obo:PATO_0002007 ; oboInOwl:hasDbXref "Image:http://en.wikipedia.org/wiki/Image:Convex_polygon_illustration2.png" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002008" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "concave 3-D shape" ; rdfs:subClassOf obo:PATO_0002266, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PATO_0001857 ] . obo:PATO_0002009 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002009" ; oboInOwl:inSubset pato:attribute_slim, pato:cell_quality ; a owl:Class ; rdfs:label "branchiness" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002011 obo:IAO_0000115 "A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells." ; oboInOwl:hasExactSynonym "tumorous" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002011" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "neoplastic" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002014 obo:IAO_0000115 "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002014" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "structure, cavities" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002021 obo:IAO_0000115 "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers)." ; oboInOwl:hasDbXref "Image:http://upload.wikimedia.org/wikipedia/commons/d/d2/Cone_3d.png" ; oboInOwl:hasExactSynonym "cone-shaped" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002021" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "conical" ; rdfs:subClassOf obo:PATO_0002007 . obo:PATO_0002026 obo:IAO_0000115 "A quality of a single process inhering in a bearer by virtue of the bearer's not increasing over time." ; obo:RO_0002604 obo:PATO_0001818 ; dcterms:contributor ; oboInOwl:creation_date "2008-12-18T12:49:19Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002026" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "non-progressive" ; rdfs:subClassOf obo:PATO_0000057 . obo:PATO_0002034 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being unseparated into parts or divisions." ; dcterms:contributor ; oboInOwl:creation_date "2009-01-27T11:53:46Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "unseparated" ; oboInOwl:id "PATO:0002034" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "undivided" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002037 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure." ; dcterms:contributor ; oboInOwl:creation_date "2009-02-03T11:13:19Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002037" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "degeneration" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002039 obo:IAO_0000115 "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." ; obo:RO_0002604 obo:PATO_0002040 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002039" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "biconcave" ; rdfs:subClassOf obo:PATO_0001857 . obo:PATO_0002040 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being convex on both sides or surface." ; obo:RO_0002604 obo:PATO_0002039 ; oboInOwl:hasDbXref "Image:http://www.thefreedictionary.com/_/viewer.aspx?path=hm&name=A4bicovx" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002040" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "biconvex" ; rdfs:subClassOf obo:PATO_0001355 . obo:PATO_0002041 obo:IAO_0000115 "A diameter that is along the anterior-posterior axis." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002041" ; oboInOwl:inSubset pato:attribute_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "anterior-posterior diameter" ; rdfs:subClassOf obo:PATO_0001334 . obo:PATO_0002042 obo:IAO_0000115 "An anterior-posterior diameter quality which is relatively small." ; obo:RO_0002604 obo:PATO_0002043 ; oboInOwl:hasExactSynonym "low anterior-posterior diameter" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002042" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased anterior-posterior diameter" ; rdfs:subClassOf obo:PATO_0001715, obo:PATO_0002041 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002041 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002043 obo:IAO_0000115 "An anterior-posterior diameter quality which is relatively large." ; obo:RO_0002604 obo:PATO_0002042 ; oboInOwl:hasExactSynonym "high anterior-posterior diameter" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002043" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased anterior-posterior diameter" ; rdfs:subClassOf obo:PATO_0001714, obo:PATO_0002041 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002041 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002044 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being a quadrilateral with two parallel sides." ; oboInOwl:hasExactSynonym "trapezoidal" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002044" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "trapezoid" ; rdfs:subClassOf obo:PATO_0001988 . obo:PATO_0002045 obo:IAO_0000115 "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." ; dcterms:contributor ; oboInOwl:creation_date "2009-02-15T08:11:41Z" ; oboInOwl:hasExactSynonym "dendriform", "dendroid", "dendroidal" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002045" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "dendritic" ; rdfs:subClassOf obo:PATO_0000402 . obo:PATO_0002049 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis and towards the side." ; dcterms:contributor ; oboInOwl:creation_date "2009-03-13T12:36:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002049" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "lateral and rotional curvature" ; rdfs:subClassOf obo:PATO_0001787 . obo:PATO_0002051 obo:IAO_0000115 "An occurrence which is relatively high." ; obo:RO_0002604 obo:PATO_0002052 ; dcterms:contributor ; oboInOwl:creation_date "2009-03-26T11:10:11Z" ; oboInOwl:hasExactSynonym "increased incidence" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002051" ; a owl:Class ; rdfs:label "increased occurrence" ; rdfs:subClassOf obo:PATO_0000057, obo:PATO_0002304 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000057 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002052 obo:IAO_0000115 "An occurrence which is relatively low." ; obo:RO_0002604 obo:PATO_0002051 ; dcterms:contributor ; oboInOwl:creation_date "2009-03-26T11:12:35Z" ; oboInOwl:hasExactSynonym "decreased incidence" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002052" ; a owl:Class ; rdfs:label "decreased occurrence" ; rdfs:subClassOf obo:PATO_0000057, obo:PATO_0002302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000057 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002055 obo:IAO_0000115 "A fragility which is relatively high." ; obo:RO_0002604 obo:PATO_0002056 ; dcterms:contributor ; oboInOwl:creation_date "2009-03-26T04:01:37Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002055" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased fragility" ; rdfs:subClassOf obo:PATO_0001362, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001362 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002056 obo:IAO_0000115 "A fragility which is relatively low." ; obo:RO_0002604 obo:PATO_0002055 ; dcterms:contributor ; oboInOwl:creation_date "2009-03-26T04:02:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002056" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased fragility" ; rdfs:subClassOf obo:PATO_0001362, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001362 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002062 dcterms:contributor ; oboInOwl:creation_date "2009-06-05T09:16:46Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002062" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "physical quality of a process" ; rdfs:subClassOf obo:PATO_0001236 . obo:PATO_0002076 obo:IAO_0000115 "A behavioral quality inhering in a bearer by virtue of the bearer's movement." ; dcterms:contributor ; oboInOwl:creation_date "2009-09-18T02:04:48Z" ; oboInOwl:hasExactSynonym "movement behavioural quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002076" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "movement behavioral quality" ; rdfs:subClassOf obo:PATO_0000186 . obo:PATO_0002078 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." ; dcterms:contributor ; oboInOwl:creation_date "2009-09-18T02:19:20Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002078" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "hollow" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0002083 obo:IAO_0000115 "Having extra or fewer parts." ; dcterms:contributor ; oboInOwl:creation_date "2009-09-21T10:41:58Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002083" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "altered number of" ; rdfs:subClassOf obo:PATO_0000051, obo:PATO_0001555 . obo:PATO_0002087 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's being short and wide and tapered distally." ; dcterms:contributor ; oboInOwl:creation_date "2009-09-30T09:53:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002087" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "bullet-shaped" ; rdfs:subClassOf obo:PATO_0002007 . obo:PATO_0002089 obo:IAO_0000115 "A structure quality inhering in a bearer by virtue of the bearer's body containing more than one cyst - formations of sac-like closed membranous structures not associated with neoplasia." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-01T03:02:54Z" ; oboInOwl:hasExactSynonym "multicystic" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002089" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "polycystic" ; rdfs:subClassOf obo:PATO_0001673 . obo:PATO_0002093 obo:IAO_0000115 "A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-05T12:01:13Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002093" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "ballooning" ; rdfs:subClassOf obo:PATO_0000595 . obo:PATO_0002094 obo:IAO_0000115 "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-05T12:05:23Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002094" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "basophilic" ; rdfs:subClassOf obo:PATO_0070045 . obo:PATO_0002096 obo:IAO_0000115 "A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-05T12:47:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "benign" ; oboInOwl:id "PATO:0002096" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "neoplastic, non-malignant" ; rdfs:subClassOf obo:PATO_0002011 ; owl:disjointWith obo:PATO_0002097 . obo:PATO_0002097 obo:IAO_0000115 "A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-05T12:50:22Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002097" ; oboInOwl:inSubset pato:disposition_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "neoplastic, malignant" ; rdfs:subClassOf obo:PATO_0002011 . obo:PATO_0002112 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes." ; obo:RO_0002604 obo:PATO_0001821 ; dcterms:contributor ; oboInOwl:creation_date "2009-10-05T03:37:05Z" ; oboInOwl:hasAlternativeId "PATO:0000649" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "permeable", "pierced" ; oboInOwl:id "PATO:0002112" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "perforate" ; rdfs:subClassOf obo:PATO_0002014 . obo:PATO_0002118 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's being present in more than two copies." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-06T03:28:38Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002118" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "multiple" ; rdfs:subClassOf obo:PATO_0000470 . obo:PATO_0002124 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-06T04:37:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002124" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "laminar" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002135 obo:IAO_0000115 "A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-26T01:03:17Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002135" ; a owl:Class ; rdfs:label "delayed closure" ; rdfs:subClassOf obo:PATO_0000502 . obo:PATO_0002141 obo:IAO_0000115 "A density quality which lacks pattern." ; dcterms:contributor ; oboInOwl:creation_date "2009-10-28T01:57:53Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002141" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "irregular density" ; rdfs:subClassOf obo:PATO_0001019 . obo:PATO_0002142 dcterms:contributor ; oboInOwl:creation_date "2009-10-28T03:14:54Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002142" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "bracket" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002143 dcterms:contributor ; oboInOwl:creation_date "2009-10-30T02:18:39Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002143" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "sloped downward" ; rdfs:subClassOf obo:PATO_0001481 . obo:PATO_0002149 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer exhibiting increased density resulting in exhibiting increased degree of radiopacity (in X-rays)." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-03T02:59:08Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002149" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "ivory" ; rdfs:subClassOf obo:PATO_0001788 . obo:PATO_0002154 obo:IAO_0000115 "A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the abdomen of an organism." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-06T01:14:42Z" ; oboInOwl:hasExactSynonym "splayed anterior (human torso)", "splayed inferior (human head)" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002154" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "splayed ventral" ; rdfs:subClassOf obo:PATO_0001785 . obo:PATO_0002155 obo:IAO_0000115 "A rotation quality inhering in a bearer by virtue of being rotated towards the middle of an organism." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-06T02:23:28Z" ; oboInOwl:hasExactSynonym "internally rotated" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002155" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "medially rotated" ; rdfs:subClassOf obo:PATO_0001599 . obo:PATO_0002156 obo:IAO_0000115 "A rotation quality inhering in a bearer by virtue of being rotated towards the side of an organism." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-06T02:25:10Z" ; oboInOwl:hasExactSynonym "externally rotated" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002156" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "laterally rotated" ; rdfs:subClassOf obo:PATO_0001599 . obo:PATO_0002157 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being slightly out of its usual or proper place, or position." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-06T03:34:15Z" ; oboInOwl:hasAlternativeId "PATO:0002160" ; oboInOwl:hasExactSynonym "partial dislocated towards", "subluxation", "suluxated towards" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002157" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "partially dislocated" ; rdfs:subClassOf obo:PATO_0001852 . obo:PATO_0002161 obo:IAO_0000115 "Having two horns or horn-shaped branches." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-11T02:37:52Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002161" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "bicornuate" ; rdfs:subClassOf obo:PATO_0002008 . obo:PATO_0002162 obo:IAO_0000115 "A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-26T02:34:06Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002162" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "high-arched" ; rdfs:subClassOf obo:PATO_0001594, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001594 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002163 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it into the surface or boundary of another entity." ; dcterms:contributor ; oboInOwl:creation_date "2009-11-26T04:50:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002163" ; oboInOwl:inSubset pato:mpath_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "herniated into" ; rdfs:subClassOf obo:PATO_0001645 . obo:PATO_0002165 obo:IAO_0000115 "To bent or hang downwards." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-02T03:32:55Z" ; oboInOwl:hasExactSynonym "sagging" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002165" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "drooping" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002166 obo:IAO_0000115 "A duration quality of a process inhering in a bearer by virtue of the bearer's premature completion of the closure of the opening of an anatomical entity." ; dcterms:contributor ; oboInOwl:creation_date "2009-12-02T04:10:10Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002166" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "premature closure" ; rdfs:subClassOf obo:PATO_0000694 . obo:PATO_0002169 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being split along the median axis." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-03T04:37:15Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002169" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "split medially" ; rdfs:subClassOf obo:PATO_0001786 . obo:PATO_0002175 obo:IAO_0000115 "A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-25T09:14:42Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002175" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "spatial deviation" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0002176 obo:IAO_0000115 "A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the side." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-25T09:16:04Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002176" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "deviation towards the lateral side" ; rdfs:subClassOf obo:PATO_0002175 . obo:PATO_0002177 obo:IAO_0000115 "A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the middle." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-25T09:16:56Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002177" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "deviation towards the medial side" ; rdfs:subClassOf obo:PATO_0002175 . obo:PATO_0002179 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards to point of attachment or origin." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-25T12:34:48Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002179" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mislocalised proximally" ; rdfs:subClassOf obo:PATO_0000628 . obo:PATO_0002180 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being free of curves, bends, or angles." ; dcterms:contributor ; oboInOwl:creation_date "2010-02-28T08:54:59Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002180" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "straight" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002181 obo:IAO_0000115 "A positional quality inhering in a bearer by virtue the bearer's being changed in position." ; dcterms:contributor ; oboInOwl:creation_date "2010-03-01T02:56:33Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002181" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "displaced" ; rdfs:subClassOf obo:PATO_0000140 . obo:PATO_0002182 obo:IAO_0000115 "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." ; dcterms:contributor ; oboInOwl:creation_date "2010-03-10T03:18:15Z" ; oboInOwl:hasAlternativeId "PATO:0002061" ; oboInOwl:hasExactSynonym "relational molecular quality" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002182" ; a owl:Class ; rdfs:label "molecular quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0002198 obo:IAO_0000115 "A quality inhering in a bearer by virtue of its constitution." ; dcterms:contributor ; oboInOwl:creation_date "2010-03-15T04:35:27Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002198" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "quality of a substance" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0002212 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being small or narrow in circumference or width in proportion to length or height." ; dcterms:contributor ; oboInOwl:creation_date "2010-07-08T01:32:26Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "gracile" ; oboInOwl:id "PATO:0002212" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "slender" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002254 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." ; dcterms:contributor ; oboInOwl:creation_date "2010-08-16T03:59:34Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "compressed" ; oboInOwl:id "PATO:0002254" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:comment "Becoming flat but not necessarily completely flat." ; rdfs:label "flattened" ; rdfs:subClassOf obo:PATO_0001591 . obo:PATO_0002255 obo:IAO_0000115 "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-01T10:27:48Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "channeled", "creased" ; oboInOwl:id "PATO:0002255" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "grooved" ; rdfs:subClassOf obo:PATO_0000150 . obo:PATO_0002257 obo:IAO_0000115 "A cuscpidate quality inhering in a bearer by virtue of the bearer possessing more than one cusp." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-08T02:23:22Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002257" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "multicuspidate" ; rdfs:subClassOf obo:PATO_0001973 . obo:PATO_0002265 obo:IAO_0000115 "A behavioral quality of a process inhering in a bearer by virtue of the bearer's disposition to exhibit marked activity." ; dcterms:contributor ; oboInOwl:creation_date "2010-09-21T06:56:58Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002265" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "behavioural activity" ; rdfs:subClassOf obo:PATO_0000186 . obo:PATO_0002266 obo:IAO_0000115 "A shape that inheres in a 3 dimensional entity." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-05T12:31:16Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002266" ; a owl:Class ; rdfs:label "3-D shape" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002269 obo:IAO_0000115 "A structural quality of the collection or massing of one physical object within another physical object." ; dcterms:contributor ; oboInOwl:creation_date "2010-10-26T01:57:02Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "pooled" ; oboInOwl:id "PATO:0002269" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim, pato:scalar_slim ; a owl:Class ; rdfs:label "accumulation" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002270 obo:IAO_0000115 "An increased number of physical objects that are accumulated within another physical object usually as a result of a failure to break down or remove objects in a timely manner." ; obo:RO_0002604 obo:PATO_0002271 ; dcterms:contributor ; oboInOwl:creation_date "2010-10-26T02:00:20Z" ; oboInOwl:hasExactSynonym "accumulated" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002270" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased accumulation" ; rdfs:subClassOf obo:PATO_0002269 . obo:PATO_0002281 obo:IAO_0000115 "A cuscpidate quality inhering in a bearer by virtue of the bearer possessing two cusps." ; dcterms:contributor ; oboInOwl:creation_date "2011-02-07T03:13:18Z" ; oboInOwl:hasExactSynonym "bicuspid" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002281" ; a owl:Class ; rdfs:label "biscupidate" ; rdfs:subClassOf obo:PATO_0002257 . obo:PATO_0002282 obo:IAO_0000115 "A mobility which is relative high." ; obo:RO_0002604 obo:PATO_0002283 ; dcterms:contributor ; oboInOwl:creation_date "2011-03-09T09:16:03Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002282" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased mobility" ; rdfs:subClassOf obo:PATO_0000299, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000299 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002283 obo:IAO_0000115 "A mobility which is relative low." ; obo:RO_0002604 obo:PATO_0002282 ; dcterms:contributor ; oboInOwl:creation_date "2011-03-09T09:16:47Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002283" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased mobility" ; rdfs:subClassOf obo:PATO_0000299, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000299 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002287 obo:IAO_0000115 "An elasticity which is relatively high." ; obo:RO_0002604 obo:PATO_0002288 ; dcterms:contributor ; oboInOwl:creation_date "2011-03-30T11:50:21Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002287" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased elasticity" ; rdfs:subClassOf obo:PATO_0001171, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001171 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002288 obo:IAO_0000115 "An elasticity which is relatively low." ; obo:RO_0002604 obo:PATO_0002287 ; dcterms:contributor ; oboInOwl:creation_date "2011-03-30T11:50:39Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002288" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased elasticity" ; rdfs:subClassOf obo:PATO_0001171, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001171 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002290 dcterms:contributor ; oboInOwl:creation_date "2011-04-18T05:11:33Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002290" ; a owl:Class ; rdfs:label "aplastic/hypoplastic" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0002291 obo:IAO_0000115 "Absence of a tissue or organ due to failure to develop." ; dcterms:contributor ; oboInOwl:creation_date "2011-04-18T05:17:34Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002291" ; a owl:Class ; rdfs:label "agenesis" ; rdfs:subClassOf obo:PATO_0040060 . obo:PATO_0002297 obo:IAO_0000115 "A cellular motility which is lower relative to the normal or average." ; obo:RO_0002604 obo:PATO_0002298 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002297" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased cellular motility" ; rdfs:subClassOf obo:PATO_0001488, obo:PATO_0002303 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001488 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002298 obo:IAO_0000115 "A cellular motility which is higher relative to the normal or average." ; obo:RO_0002604 obo:PATO_0002297 ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002298" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "increased cellular motility" ; rdfs:subClassOf obo:PATO_0001488, obo:PATO_0002305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001488 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002299 obo:IAO_0000115 "A cylindrical shape that is hollow." ; dcterms:contributor ; oboInOwl:creation_date "2011-06-08T06:33:50Z" ; oboInOwl:hasExactSynonym "tube like", "tube-shaped", "tubulate" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002299" ; a owl:Class ; rdfs:label "tubular" ; rdfs:subClassOf obo:PATO_0001873, obo:PATO_0002078 . obo:PATO_0002300 obo:IAO_0000115 "A quality that has a value that is increased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002301 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:39:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002300" ; a owl:Class ; rdfs:label "increased quality" ; rdfs:subClassOf obo:PATO_0000069 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002301 obo:IAO_0000115 "A quality that has a value that is decreased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002300 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:40:15Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002301" ; a owl:Class ; rdfs:label "decreased quality" ; rdfs:subClassOf obo:PATO_0000069 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000001 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002302 obo:IAO_0000115 "A quality of a process that has a value that is decreased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002304 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:50:59Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002302" ; a owl:Class ; rdfs:label "decreased process quality" ; rdfs:subClassOf obo:PATO_0001236, obo:PATO_0002301 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002303 obo:IAO_0000115 "A quality of an object that has a value that is decreased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002305 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:51:54Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002303" ; a owl:Class ; rdfs:label "decreased object quality" ; rdfs:subClassOf obo:PATO_0001241, obo:PATO_0002301 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001241 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002304 obo:IAO_0000115 "A quality of a process that has a value that is increased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002302 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:53:08Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002304" ; a owl:Class ; rdfs:label "increased process quality" ; rdfs:subClassOf obo:PATO_0001236, obo:PATO_0002300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002305 obo:IAO_0000115 "A quality of an object that has a value that is increased compared to normal or average." ; obo:RO_0002604 obo:PATO_0002303 ; dcterms:contributor ; oboInOwl:creation_date "2011-06-16T06:54:01Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002305" ; a owl:Class ; rdfs:label "increased object quality" ; rdfs:subClassOf obo:PATO_0001241, obo:PATO_0002300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001241 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002317 obo:IAO_0000115 """A convex quadrilateral is a parallelogram if and only if any one of the following statements are true: 1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation. 2. The opposite sides are congruent in pairs. 3. The diagonals bisect each other. 4. The opposite angles are congruent in pairs. 5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law) 6.It possesses rotational symmetry. 7.One pair of opposite sides are parallel and congruent. 8.Two pairs of adjacent angles are supplementary.""" ; dcterms:contributor ; oboInOwl:creation_date "2011-10-12T12:33:07Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002317" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "parallelogram" ; rdfs:subClassOf obo:PATO_0001988 . obo:PATO_0002318 obo:IAO_0000115 "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" ; dcterms:contributor ; oboInOwl:creation_date "2011-10-12T12:45:16Z" ; oboInOwl:hasExactSynonym "Lamé curve" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002318" ; a owl:Class ; rdfs:label "superelliptic" ; rdfs:subClassOf obo:PATO_0002006 . obo:PATO_0002323 obo:IAO_0000115 "A temporal distribution pattern of process occurrences within a regulation/reference process." ; dcterms:contributor ; oboInOwl:creation_date "2011-11-22T01:12:28Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002323" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "temporal distribution quality" ; rdfs:subClassOf obo:PATO_0002062 . obo:PATO_0002324 obo:IAO_0000115 "The temporal relation between the end of the process with respect to a reference process." ; dcterms:contributor ; oboInOwl:creation_date "2011-11-23T11:46:00Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "completeness", "extent" ; oboInOwl:id "PATO:0002324" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "offset quality" ; rdfs:subClassOf obo:PATO_0002323 . obo:PATO_0002325 obo:IAO_0000115 "The temporal relation between the start of the process with respect to a reference process." ; dcterms:contributor ; oboInOwl:creation_date "2011-11-23T11:47:34Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:hasRelatedSynonym "initiation" ; oboInOwl:id "PATO:0002325" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "onset quality" ; rdfs:subClassOf obo:PATO_0002323 . obo:PATO_0002326 obo:IAO_0000115 "An orientation inhering in a bearer by virtue of the bearer's placement at an angle." ; dcterms:contributor ; oboInOwl:creation_date "2011-11-23T12:06:09Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002326" ; oboInOwl:inSubset pato:attribute_slim, pato:relational_slim ; a owl:Class ; rdfs:label "angle" ; rdfs:subClassOf obo:PATO_0000133 . obo:PATO_0002327 obo:IAO_0000115 "An angle which is relatively high." ; obo:RO_0002604 obo:PATO_0002328 ; dcterms:contributor ; oboInOwl:creation_date "2011-11-23T12:06:38Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002327" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased angle to" ; rdfs:subClassOf obo:PATO_0001475, obo:PATO_0002326 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002326 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002328 obo:IAO_0000115 "An angle which is relatively low." ; obo:RO_0002604 obo:PATO_0002327 ; dcterms:contributor ; oboInOwl:creation_date "2011-11-23T12:06:54Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002328" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased angle to" ; rdfs:subClassOf obo:PATO_0001476, obo:PATO_0002326 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002326 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002358 obo:IAO_0000115 "An elongated raised margin or border." ; dcterms:contributor ; oboInOwl:creation_date "2012-02-21T12:27:39Z" ; oboInOwl:hasExactSynonym "ridge-like" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002358" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "ridged" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002359 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's width being notably higher than its length." ; dcterms:contributor ; oboInOwl:creation_date "2012-03-13T06:04:00Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002359" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "broad" ; rdfs:subClassOf obo:PATO_0000052 . obo:PATO_0002360 obo:IAO_0000115 "A disposition that can be compared on a linear scale - that is that it can be increased or decreased." ; dcterms:contributor ; oboInOwl:creation_date "2012-03-16T06:31:50Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002360" ; oboInOwl:inSubset pato:attribute_slim, pato:disposition_slim, pato:relational_slim ; a owl:Class ; rdfs:label "tendency" ; rdfs:subClassOf obo:PATO_0001727 . obo:PATO_0002361 obo:IAO_0000115 "A tendency which is relatively high." ; obo:RO_0002604 obo:PATO_0002362 ; dcterms:contributor ; oboInOwl:creation_date "2012-03-16T06:31:57Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002361" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "increased tendency" ; rdfs:subClassOf obo:PATO_0002305, obo:PATO_0002360 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002360 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002362 obo:IAO_0000115 "A tendency which is relatively low." ; obo:RO_0002604 obo:PATO_0002361 ; dcterms:contributor ; oboInOwl:creation_date "2012-03-16T06:32:57Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002362" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "decreased tendency" ; rdfs:subClassOf obo:PATO_0002303, obo:PATO_0002360 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002360 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0002400 obo:IAO_0000115 "Having a spindle-like shape that is wide in the middle and tapers at both ends." ; dcterms:contributor ; oboInOwl:creation_date "2012-12-07T05:43:25Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002400" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "fusiform" ; rdfs:subClassOf obo:PATO_0001409 . obo:PATO_0002403 obo:IAO_0000115 "Affecting all regions without specificity of distribution." ; dcterms:contributor ; oboInOwl:creation_date "2012-12-17T10:41:37Z" ; oboInOwl:hasExactSynonym "generalised" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002403" ; oboInOwl:inSubset pato:hpo_slim, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "generalized" ; rdfs:subClassOf obo:PATO_0000060 . obo:PATO_0002418 obo:IAO_0000115 "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." ; dcterms:contributor ; oboInOwl:creation_date "2012-12-17T03:01:19Z" ; oboInOwl:hasExactSynonym "eosinophilic" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002418" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment "Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic." ; rdfs:label "acidophilic" ; rdfs:subClassOf obo:PATO_0070045 . obo:PATO_0002422 obo:IAO_0000115 "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." ; dcterms:contributor ; oboInOwl:creation_date "2012-12-17T03:11:10Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002422" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:comment "Acinus is Latin for berry." ; rdfs:label "acinar" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0002444 obo:IAO_0000115 "A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material." ; dcterms:contributor ; oboInOwl:creation_date "2013-01-29T11:03:49Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002444" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "mineralized" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0002462 obo:IAO_0000115 "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." ; dcterms:contributor ; oboInOwl:creation_date "2013-09-15T11:34:15Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002462" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "collagenous" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0002468 obo:IAO_0000115 "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." ; dcterms:contributor ; oboInOwl:creation_date "2013-09-15T11:48:26Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002468" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "distensible" ; rdfs:subClassOf obo:PATO_0015008 . obo:PATO_0002478 obo:IAO_0000115 "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." ; dcterms:contributor ; oboInOwl:creation_date "2013-09-15T12:29:15Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002478" ; oboInOwl:inSubset pato:cell_quality, pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "transversely striated" ; rdfs:subClassOf obo:PATO_0001410 . obo:PATO_0002505 obo:IAO_0000115 "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." ; dcterms:contributor ; oboInOwl:creation_date "2013-10-21T05:44:34Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002505" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "nucleated" ; rdfs:subClassOf obo:PATO_0001404 . obo:PATO_0002507 obo:IAO_0000115 "A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin." ; dcterms:contributor ; oboInOwl:creation_date "2014-02-04T12:38:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002507" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "keratinous" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0002519 obo:IAO_0000115 "A structural quality inhering in a bearer by virtue of the bearer's having an open, latticed, or porous structure; used especially of bone." ; dcterms:contributor ; oboInOwl:creation_date "2014-02-10T01:33:14Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0002519" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "cancellous" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0005021 obo:IAO_0000115 "Cuspidate quality inhering in a bearer by virtue of the bearer's possessing a single cusp." ; dcterms:contributor ; oboInOwl:creation_date "2014-10-17T14:14:04Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0005021" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "unicuspidate" ; rdfs:subClassOf obo:PATO_0001973 . obo:PATO_0010001 obo:IAO_0000115 "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." ; dcterms:contributor ; oboInOwl:creation_date "2014-12-12T08:43:17Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0010001" ; a owl:Class ; rdfs:label "disconnected" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0010006 obo:IAO_0000115 "A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure." ; dcterms:contributor ; oboInOwl:creation_date "2021-01-23T11:31:53Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0010006" ; a owl:Class ; rdfs:comment "Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts." ; rdfs:label "cell morphology" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0015001 obo:IAO_0000115 "Absence due to a degenerative process." ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0015001" ; oboInOwl:inSubset pato:absent_slim, pato:value_slim ; a owl:Class ; rdfs:label "absence due to degeneration" ; rdfs:subClassOf obo:PATO_0000639, obo:PATO_0040060 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000639 obo:PATO_0040060 ) ] . obo:PATO_0015007 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the degree to which the bearers stands out or projects beyond a surface or line." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0015007" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "prominence" ; rdfs:subClassOf obo:PATO_0001018 . obo:PATO_0015008 obo:IAO_0000115 "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0015008" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "distensibility" ; rdfs:subClassOf obo:PATO_0000141 . obo:PATO_0040019 obo:IAO_0000115 "Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process." ; dc:date "2018-11-12T23:16:17Z"^^xsd:dateTime ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040019" ; a owl:Class ; rdfs:label "fibrotic" ; rdfs:subClassOf obo:PATO_0000025 . obo:PATO_0040030 obo:IAO_0000115 "A width and length quality which is relatively small, where both width and length are decreased." ; obo:RO_0002604 obo:PATO_0040031 ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040030" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "decreased width and length" ; rdfs:subClassOf obo:PATO_0000574, obo:PATO_0000599 . obo:PATO_0040034 obo:IAO_0000115 "A broken quality where an entity is cracked or broken, usually a bone." ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040034" ; a owl:Class ; rdfs:label "fractured" ; rdfs:subClassOf obo:PATO_0001444 . obo:PATO_0040040 obo:IAO_0000115 "A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." ; dcterms:contributor ; oboInOwl:hasExactSynonym "compression fractured", "fractured, compression", "fractured, wedge", "wedge fractured" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040040" ; a owl:Class ; rdfs:label "compression-fractured" ; rdfs:subClassOf obo:PATO_0040034 . obo:PATO_0040041 obo:IAO_0000115 "A fractured quality in which the fragment of bone tears away from the main mass of bone as a result of physical trauma." ; dcterms:contributor ; oboInOwl:hasExactSynonym "fractured, avulsion" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040041" ; a owl:Class ; rdfs:label "avulsion fractured" ; rdfs:subClassOf obo:PATO_0040034 . obo:PATO_0040042 obo:IAO_0000115 "A proportionality quality inhering in a bearer by virtue of the bearer's decreased magnitude in respect to a related entity." ; dcterms:contributor ; oboInOwl:hasExactSynonym "decreased proportion", "decreased proportionality", "decreased quotient", "decreased ratio" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040042" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:comment "Example: decreased proportion of CD4 T cells relative to total T cells." ; rdfs:label "decreased proportionality to" ; rdfs:subClassOf obo:PATO_0001470 . obo:PATO_0040043 obo:IAO_0000115 "A proportionality quality inhering in a bearer by virtue of the bearer's increased magnitude in respect to a related entity." ; dcterms:contributor ; oboInOwl:hasExactSynonym "increased proportion", "increased proportionality", "increased quotient", "increased ratio" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040043" ; oboInOwl:inSubset pato:relational_slim ; a owl:Class ; rdfs:comment "Example: increased proportion of CD4 T cells relative to total T cells." ; rdfs:label "increased proportionality to" ; rdfs:subClassOf obo:PATO_0001470 . obo:PATO_0040047 obo:IAO_0000115 "Existing or functioning as though broken into separate parts; disorganized; disunified." ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040047" ; a owl:Class ; rdfs:comment "Moved to a child of wholeness because broken implies a trauma and fragmented could be caused by a developmental process. See HP:0100168 Fragmented epiphyses as an example." ; rdfs:label "fragmented" ; rdfs:subClassOf obo:PATO_0001442 . obo:PATO_0040048 obo:IAO_0000115 "Red due to increase blood circulation in a defined area." ; dcterms:contributor ; oboInOwl:hasExactSynonym "erythema", "skin redness" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040048" ; a owl:Class ; rdfs:label "erythematous" ; rdfs:subClassOf obo:PATO_0000051 . obo:PATO_0040058 obo:IAO_0000115 "A quality denoting the lack of a physical entity or object, such as a chemical." ; oboInOwl:created_by "http://orcid.org/0000-0001-5208-3432" ; oboInOwl:hasExactSynonym "physical absence" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040058" ; oboInOwl:inSubset pato:absent_slim ; a owl:Class ; rdfs:label "absence of physical object" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0040060 obo:IAO_0000115 "A quality denoting the lack of an anatomical entity or cellular component." ; oboInOwl:created_by "http://orcid.org/0000-0001-5208-3432" ; oboInOwl:hasExactSynonym "anatomical entity absence" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0040060" ; oboInOwl:inSubset pato:absent_slim ; a owl:Class ; rdfs:comment "Absence of anatomical entity should only be used when all of the entity is absent. For example, absent teeth would mean all teeth are absent not some teeth are absent." ; rdfs:label "absence of anatomical entity" ; rdfs:subClassOf obo:PATO_0000051, obo:PATO_0040058 . obo:PATO_0045000 obo:IAO_0000115 "A rate which is relatively normal." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045000" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal rate" ; rdfs:subClassOf obo:PATO_0000161, obo:PATO_0045073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000161 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045001 obo:IAO_0000115 "A quality of an object that has a value that is normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-21T14:11:01Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045001" ; a owl:Class ; rdfs:label "normal object quality" ; rdfs:subClassOf obo:PATO_0001241 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001241 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045007 obo:IAO_0000115 "A behavioural quality of a process inhering in a bearer by virtue of the bearer's exhibiting normal or average activity." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045007" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal behavioural activity" ; rdfs:subClassOf obo:PATO_0001707, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001707 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045008 obo:IAO_0000115 "A cellular motility which is normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045008" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal cellular motility" ; rdfs:subClassOf obo:PATO_0001488, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001488 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045009 obo:IAO_0000115 "A coiling which is normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045009" ; oboInOwl:inSubset pato:cell_quality, pato:value_slim ; a owl:Class ; rdfs:label "normal coiling" ; rdfs:subClassOf obo:PATO_0000404, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000404 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045010 obo:IAO_0000115 "A concentration which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045010" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal concentration" ; rdfs:subClassOf obo:PATO_0001159, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001159 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045011 obo:IAO_0000115 "A contractility which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045011" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal contractility" ; rdfs:subClassOf obo:PATO_0001690, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001690 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045013 obo:IAO_0000115 "A curvature which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045013" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal curvature" ; rdfs:subClassOf obo:PATO_0000406, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000406 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045016 obo:IAO_0000115 "An elasticity which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045016" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal elasticity" ; rdfs:subClassOf obo:PATO_0001171, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001171 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045021 obo:IAO_0000115 "A flexibility which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045021" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal flexibility" ; rdfs:subClassOf obo:PATO_0001544, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001544 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045025 obo:IAO_0000115 "A fragility which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045025" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal fragility" ; rdfs:subClassOf obo:PATO_0001362, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001362 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045026 obo:IAO_0000115 "A life span which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045026" ; a owl:Class ; rdfs:label "normal life span" ; rdfs:subClassOf obo:PATO_0000050, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000050 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045030 obo:IAO_0000115 "A mass which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045030" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal mass" ; rdfs:subClassOf obo:PATO_0000125, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045031 obo:IAO_0000115 "A density which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045031" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal mass density" ; rdfs:subClassOf obo:PATO_0001164, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001164 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045032 obo:IAO_0000115 "A mobility which is relatively normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045032" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal mobility" ; rdfs:subClassOf obo:PATO_0000299, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000299 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045038 obo:IAO_0000115 "A photosensitivity which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045038" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal photosensitivity" ; rdfs:subClassOf obo:PATO_0000547, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000547 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045040 obo:IAO_0000115 "A position which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045040" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal position" ; rdfs:subClassOf obo:PATO_0000140, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000140 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045041 obo:IAO_0000115 "An angle which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045041" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal angle to" ; rdfs:subClassOf obo:PATO_0002326, obo:PATO_0045040 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002326 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045044 obo:IAO_0000115 "A pressure which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045044" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal pressure" ; rdfs:subClassOf obo:PATO_0001025, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001025 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045047 obo:IAO_0000115 "A resistance to a stimulus which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045047" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal resistance to" ; rdfs:subClassOf obo:PATO_0001178, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001178 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045049 obo:IAO_0000115 "A sensitivity toward an external stimulus which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045049" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal sensitivity toward" ; rdfs:subClassOf obo:PATO_0000516, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000516 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045050 obo:IAO_0000115 "A size quality which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045050" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal size" ; rdfs:subClassOf obo:PATO_0000117, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000117 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045052 obo:IAO_0000115 "A depth quality which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045052" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal depth" ; rdfs:subClassOf obo:PATO_0001595, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001595 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045053 obo:IAO_0000115 "A height which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045053" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal height" ; rdfs:subClassOf obo:PATO_0000119, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045054 obo:IAO_0000115 "A length quality which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045054" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal length" ; rdfs:subClassOf obo:PATO_0000122, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000122 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045055 obo:IAO_0000115 "A diameter which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045055" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal diameter" ; rdfs:subClassOf obo:PATO_0001334 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001334 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045056 obo:IAO_0000115 "An anterior-posterior diameter which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045056" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal anterior-posterior diameter" ; rdfs:subClassOf obo:PATO_0002041, obo:PATO_0045055 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002041 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045057 obo:IAO_0000115 "A perimeter which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045057" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal perimeter" ; rdfs:subClassOf obo:PATO_0001711, obo:PATO_0045054 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001711 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045058 obo:IAO_0000115 "A circumference which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045058" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal circumference" ; rdfs:subClassOf obo:PATO_0001648, obo:PATO_0045057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001648 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045059 obo:IAO_0000115 "A thickness which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045059" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal thickness" ; rdfs:subClassOf obo:PATO_0000915, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000915 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045060 obo:IAO_0000115 "A volume which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045060" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal volume" ; rdfs:subClassOf obo:PATO_0000918, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000918 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045061 obo:IAO_0000115 "A width which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045061" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal width" ; rdfs:subClassOf obo:PATO_0000921, obo:PATO_0045050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000921 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045064 obo:IAO_0000115 "A strength which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045064" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal strength" ; rdfs:subClassOf obo:PATO_0001230, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001230 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045065 obo:IAO_0000115 "A fatigability which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045065" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal fatigability" ; rdfs:subClassOf obo:PATO_0001815, obo:PATO_0045064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001815 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045066 obo:IAO_0000115 "A susceptibility toward an external stimulus which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045066" ; oboInOwl:inSubset pato:disposition_slim, pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal susceptibility toward" ; rdfs:subClassOf obo:PATO_0001152, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001152 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045068 obo:IAO_0000115 "A tendency which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045068" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal tendency" ; rdfs:subClassOf obo:PATO_0002360, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0002360 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045071 obo:IAO_0000115 "A tonicity which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045071" ; oboInOwl:inSubset pato:disposition_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal tonicity" ; rdfs:subClassOf obo:PATO_0001439, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001439 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045073 obo:IAO_0000115 "A quality of a process that has a value that is normal or average." ; dcterms:contributor ; oboInOwl:creation_date "2017-12-21T14:11:01Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045073" ; a owl:Class ; rdfs:label "normal process quality" ; rdfs:subClassOf obo:PATO_0001236 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001236 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045077 obo:IAO_0000115 "A variability of size which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045077" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal variability of size" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001956 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045081 obo:IAO_0000115 "A viscosity which is relatively normal or average" ; dcterms:contributor ; oboInOwl:creation_date "2017-12-22T14:16:43Z" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045081" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal viscosity" ; rdfs:subClassOf obo:PATO_0000998, obo:PATO_0045001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000998 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045084 obo:IAO_0000115 "A duration quality of a process which is relatively normal." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045084" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal duration" ; rdfs:subClassOf obo:PATO_0001309, obo:PATO_0045073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001309 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045086 obo:IAO_0000115 "An occurrence which is relatively normal." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045086" ; oboInOwl:inSubset pato:value_slim ; a owl:Class ; rdfs:label "normal occurrence" ; rdfs:subClassOf obo:PATO_0000057, obo:PATO_0045073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000057 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045087 obo:IAO_0000115 "A frequency which is relatively normal." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045087" ; oboInOwl:inSubset pato:mpath_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal frequency" ; rdfs:subClassOf obo:PATO_0000044, obo:PATO_0045000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0000044 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0045088 obo:IAO_0000115 "A sensitivity of a process which is relatively normal." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0045088" ; oboInOwl:inSubset pato:relational_slim, pato:value_slim ; a owl:Class ; rdfs:label "normal sensitivity of a process" ; rdfs:subClassOf obo:PATO_0001457, obo:PATO_0045073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0001457 [ a owl:Restriction ; owl:onProperty obo:RO_0015010 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0050000 obo:IAO_0000115 "The number of repeated events per unit time, occurring in a repeating series. (e.g. the number of heart beats occurring over 1 minute)" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0050000" ; a owl:Class ; rdfs:label "rate of occurence" ; rdfs:subClassOf obo:PATO_0000161 . obo:PATO_0055003 obo:IAO_0000115 "A rate of occurrence that is relatively high." ; dc:date "2020-08-19T09:23:19Z"^^xsd:dateTime ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0055003" ; a owl:Class ; rdfs:label "increased rate of occurrence" ; rdfs:subClassOf obo:PATO_0050000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0050000 [ a owl:Restriction ; owl:onProperty obo:RO_0015007 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0055004 obo:IAO_0000115 "A rate of occurrence that is relatively low." ; dc:date "2020-08-19T09:24:35Z"^^xsd:dateTime ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0055004" ; a owl:Class ; rdfs:label "decreased rate of occurrence" ; rdfs:subClassOf obo:PATO_0050000 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PATO_0050000 [ a owl:Restriction ; owl:onProperty obo:RO_0015008 ; owl:someValuesFrom obo:PATO_0000461 ] ) ] . obo:PATO_0070006 obo:IAO_0000115 "A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." ; dcterms:contributor ; oboInOwl:hasDbXref "ILX:0101312", "ilxtr:BipolarPhenotype", "nifext:2" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070006" ; a owl:Class ; rdfs:comment "This is specific to cortical bipolar cells and are distinguished from retinal bipolar cell morphology which has an axon and dendrite emerging from opposite ends of the soma." ; rdfs:label "cortical bipolar morphology" ; rdfs:subClassOf obo:PATO_0070027 . obo:PATO_0070027 obo:IAO_0000115 "A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions." ; dcterms:contributor ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070027" ; a owl:Class ; rdfs:comment "This morphology type is distinct from bitufted cell morphology in that it refers to bitufted dendrite morphology rather than bitufted cell morphology." ; rdfs:label "bitufted dendrite cell morphology" ; rdfs:subClassOf obo:PATO_0010006 . obo:PATO_0070044 obo:IAO_0000115 "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." ; oboInOwl:created_by "http://orcid.org/0000-0001-7258-9596" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070044" ; a owl:Class ; rdfs:label "anatomical structure quality" ; rdfs:subClassOf obo:PATO_0001241 . obo:PATO_0070045 obo:IAO_0000115 "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." ; oboInOwl:created_by "http://orcid.org/0000-0001-7258-9596" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070045" ; a owl:Class ; rdfs:label "anatomical histological quality" ; rdfs:subClassOf obo:PATO_0070044 . obo:PATO_0070046 obo:IAO_0000115 "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." ; oboInOwl:created_by "http://orcid.org/0000-0001-7258-9596" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070046" ; a owl:Class ; rdfs:label "neutrophillic" ; rdfs:subClassOf obo:PATO_0070045 . obo:PATO_0070047 obo:IAO_0000115 "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." ; oboInOwl:created_by "http://orcid.org/0000-0001-7258-9596" ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070047" ; a owl:Class ; rdfs:label "polychromatophilic" ; rdfs:subClassOf obo:PATO_0070045 . obo:PATO_0070060 obo:IAO_0000115 "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." ; oboInOwl:hasOBONamespace "quality" ; oboInOwl:id "PATO:0070060" ; oboInOwl:inSubset pato:attribute_slim ; a owl:Class ; rdfs:label "quality of interaction of a substance with electromagnetic radiation" ; rdfs:subClassOf obo:PATO_0002198 . obo:PR_000000001 obo:IAO_0000115 "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ; oboInOwl:hasExactSynonym "natural protein" ; oboInOwl:hasNarrowSynonym "native protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000000001" ; a owl:Class ; rdfs:comment "The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]." ; rdfs:label "protein" ; rdfs:subClassOf obo:PR_000018263, obo:PR_000050567, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0006412 ] . obo:PR_000001002 obo:IAO_0000115 "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." ; oboInOwl:hasDbXref "IUPHARobj:2764", "PIRSF:PIRSF016630" ; oboInOwl:hasExactSynonym "B-lymphocyte surface antigen B4", "CD19", "T-cell surface antigen Leu-12", "differentiation antigen CD19" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001002" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD19 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001003 obo:IAO_0000115 "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." ; oboInOwl:hasDbXref "PIRSF:PIRSF028749" ; oboInOwl:hasExactSynonym "CD34", "hematopoietic progenitor cell antigen CD34" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001003" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD34 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001004 obo:IAO_0000115 "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." ; oboInOwl:hasDbXref "PIRSF:PIRSF001977" ; oboInOwl:hasExactSynonym "CD4", "T-cell differentiation antigen L3T4", "T-cell surface antigen T4/Leu-3", "T-cell surface glycoprotein CD4" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001004" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD4 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001005 obo:IAO_0000115 "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." ; oboInOwl:hasDbXref "PIRSF:PIRSF002497" ; oboInOwl:hasExactSynonym "integrin alpha with I domain" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001005" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "integrin alpha with A domain" ; rdfs:subClassOf obo:PR_000025796 . obo:PR_000001006 obo:IAO_0000115 "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." ; oboInOwl:hasBroadSynonym "T200" ; oboInOwl:hasDbXref "IUPHARobj:1852", "PIRSF:PIRSF002004" ; oboInOwl:hasExactSynonym "L-CA", "PTPRC", "leukocyte common antigen", "ly-5", "lymphocyte antigen 5" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD45" ; oboInOwl:id "PR:000001006" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "receptor-type tyrosine-protein phosphatase C" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P08575 . obo:PR_000001012 obo:IAO_0000115 "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." ; oboInOwl:hasDbXref "IUPHARobj:2452" ; oboInOwl:hasExactSynonym "CD11 antigen-like family member B", "CD11b", "CR-3 alpha chain", "ITGAM", "cell surface glycoprotein MAC-1 subunit alpha", "leukocyte adhesion receptor MO1", "neutrophil adherence receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD11B", "CR3A" ; oboInOwl:id "PR:000001012" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "integrin alpha-M" ; rdfs:subClassOf obo:PR_000001005 ; vocab:crossSpeciesExactMatch obo:PR_P11215 . obo:PR_000001013 obo:IAO_0000115 "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." ; oboInOwl:hasDbXref "IUPHARobj:2454" ; oboInOwl:hasExactSynonym "CD11 antigen-like family member C", "CD11c", "ITGAX", "Leu M5", "leukocyte adhesion glycoprotein p150,95 alpha chain", "leukocyte adhesion receptor p150,95" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD11C" ; oboInOwl:id "PR:000001013" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "integrin alpha-X" ; rdfs:subClassOf obo:PR_000001005 ; vocab:crossSpeciesExactMatch obo:PR_P20702 . obo:PR_000001014 obo:IAO_0000115 "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD45RABC", "PTPRC/iso:CD45RABC" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "B220", "CD45R" ; oboInOwl:id "PR:000001014" ; a owl:Class ; rdfs:comment "Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exons 4(A), 5(B), and 6(C)." ; rdfs:label "receptor-type tyrosine-protein phosphatase C isoform CD45RABC" ; rdfs:subClassOf obo:PR_000001006 ; vocab:crossSpeciesExactMatch obo:PR_P08575-3 . obo:PR_000001015 obo:IAO_0000115 "A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD45RA", "PTPRC/iso:CD45RA" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001015" ; a owl:Class ; rdfs:comment "Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C)." ; rdfs:label "receptor-type tyrosine-protein phosphatase C isoform CD45RA" ; rdfs:subClassOf obo:PR_000050216 ; vocab:crossSpeciesExactMatch obo:PR_P08575-8 . obo:PR_000001018 obo:IAO_0000115 "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." ; oboInOwl:hasDbXref "PIRSF:PIRSF001993" ; oboInOwl:hasExactSynonym "CD3 subunit with Ig-like domain" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001018" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "CD3 subunit with immunoglobulin domain" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001020 obo:IAO_0000115 "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2742" ; oboInOwl:hasExactSynonym "CD3E", "CD3e", "T-cell surface antigen T3/Leu-4 epsilon chain" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "T3E" ; oboInOwl:id "PR:000001020" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD3 epsilon" ; rdfs:subClassOf obo:PR_000001018 . obo:PR_000001022 obo:IAO_0000115 "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." ; oboInOwl:hasDbXref "PIRSF:PIRSF002507" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001022" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "neural cell adhesion molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001023 obo:IAO_0000115 "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." ; oboInOwl:hasDbXref "PIRSF:PIRSF501037" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001023" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "neural cell adhesion molecule NCAM" ; rdfs:subClassOf obo:PR_000001022 . obo:PR_000001024 obo:IAO_0000115 "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2769" ; oboInOwl:hasExactSynonym "CD56", "N-CAM-1", "NCAM-1", "NCAM1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "NCAM" ; oboInOwl:id "PR:000001024" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "neural cell adhesion molecule 1" ; rdfs:subClassOf obo:PR_000001023 ; vocab:crossSpeciesExactMatch obo:PR_P13591 . obo:PR_000001083 obo:IAO_0000115 "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2600", "PIRSF:PIRSF001984" ; oboInOwl:hasExactSynonym "CD2", "LFA-2", "LFA-3 receptor", "T-cell surface antigen CD2", "T-cell surface antigen T11/Leu-5", "T-cell surface glycoprotein CD2", "erythrocyte receptor", "ly-37", "lymphocyte antigen 37", "rosette receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SRBC" ; oboInOwl:id "PR:000001083" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD2 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001084 obo:IAO_0000115 "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." ; oboInOwl:hasExactSynonym "CD8A", "CD8a", "T-cell surface glycoprotein Lyt-2", "T-lymphocyte differentiation antigen T8/Leu-2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Lyt-2", "Lyt2", "MAL" ; oboInOwl:id "PR:000001084" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "T-cell surface glycoprotein CD8 alpha chain" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P01732 . obo:PR_000001085 obo:IAO_0000115 "A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." ; oboInOwl:hasDbXref "PIRSF:PIRSF002020" ; oboInOwl:hasExactSynonym "CD8B", "T-cell membrane glycoprotein Ly-3", "T-cell surface glycoprotein Lyt-3", "lymphocyte antigen 3" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD8B1", "Ly-3", "Lyt-3", "Lyt3" ; oboInOwl:id "PR:000001085" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "T-cell surface glycoprotein CD8 beta chain" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P10966 . obo:PR_000001087 obo:IAO_0000115 "A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs." ; oboInOwl:hasDbXref "IUPHAR:GPCRListForward?class=adhesion", "IUPHARfam:17" ; oboInOwl:hasExactSynonym "adhesion class GPCR", "fam:adhesion", "subfamily B2 G-protein coupled receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "secretin receptor-like G-protein coupled receptor" ; oboInOwl:id "PR:000001087" ; a owl:Class ; rdfs:comment "Category=family. Classification based on GRAFS system. [PMID:12761335]" ; rdfs:label "adhesion G-protein coupled receptor" ; rdfs:subClassOf obo:PR_000030035 . obo:PR_000001094 obo:IAO_0000115 "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." ; oboInOwl:hasDbXref "IUPHAR:GPCRListForward?class=A", "PIRSF:PIRSF800006" ; oboInOwl:hasExactSynonym "class 1 G-protein coupled receptor", "class A G-protein coupled receptor", "fam:rhodopsin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001094" ; a owl:Class ; rdfs:comment "Category=family. Classification based on GRAFS system. [PMID:12761335]" ; rdfs:label "rhodopsin-like G-protein coupled receptor" ; rdfs:subClassOf obo:PR_000030035 . obo:PR_000001128 obo:IAO_0000115 "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines." ; oboInOwl:hasDbXref "IUPHARfam:14", "PIRSF:PIRSF038545" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001128" ; a owl:Class ; rdfs:comment "Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list." ; rdfs:label "chemokine receptor" ; rdfs:subClassOf obo:PR_000001094 . obo:PR_000001197 obo:IAO_0000115 "A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF501024" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001197" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "chemokine receptor CCR1/3/1L" ; rdfs:subClassOf obo:PR_000001128 . obo:PR_000001199 obo:IAO_0000115 "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." ; oboInOwl:hasDbXref "IUPHARobj:59" ; oboInOwl:hasExactSynonym "C-C CKR-2", "CC-CKR-2", "CCR-2", "CCR2", "CD192", "JE/FIC receptor", "MCP-1 receptor", "MCP-1-R", "chemokine receptor CCR2", "monocyte chemoattractant protein 1 receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CMKBR2" ; oboInOwl:id "PR:000001199" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "C-C chemokine receptor type 2" ; rdfs:subClassOf obo:PR_000001128 ; vocab:crossSpeciesExactMatch obo:PR_P41597 . obo:PR_000001203 obo:IAO_0000115 "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." ; oboInOwl:hasDbXref "IUPHARobj:64" ; oboInOwl:hasExactSynonym "BLR2", "C-C CKR-7", "CC-CKR-7", "CCR-7", "CCR7", "CD197", "CDw197", "EBV-induced G-protein coupled receptor 1", "MIP-3 beta receptor", "chemokine receptor CCR7", "epstein-Barr virus-induced G-protein coupled receptor 1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CMKBR7", "EBI1", "EVI1", "Ebi1h" ; oboInOwl:id "PR:000001203" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "C-C chemokine receptor type 7" ; rdfs:subClassOf obo:PR_000001128 ; vocab:crossSpeciesExactMatch obo:PR_P32248 . obo:PR_000001206 obo:IAO_0000115 "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." ; oboInOwl:hasDbXref "IUPHARobj:74", "PIRSF:PIRSF501025" ; oboInOwl:hasExactSynonym "C-X3-C CKR-1", "CMK-BRL-1", "CMK-BRL1", "CX3CR1", "G-protein coupled receptor 13", "V28", "beta chemokine receptor-like 1", "chemokine receptor CX3CR1", "fractalkine receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CMKBRL1", "GPR13" ; oboInOwl:id "PR:000001206" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CX3C chemokine receptor 1" ; rdfs:subClassOf obo:PR_000001128 ; vocab:crossSpeciesExactMatch obo:PR_P49238 . obo:PR_000001254 obo:IAO_0000115 "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:58" ; oboInOwl:hasExactSynonym "C-C CKR-1", "CC-CKR-1", "CCR-1", "CCR1", "CD191", "HM145", "LD78 receptor", "MIP-1alpha-R", "RANTES-R", "chemokine receptor CCR1", "macrophage inflammatory protein 1-alpha receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CMKBR1", "CMKR1", "SCYAR1" ; oboInOwl:id "PR:000001254" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "C-C chemokine receptor type 1" ; rdfs:subClassOf obo:PR_000001197 ; vocab:crossSpeciesExactMatch obo:PR_P32246 . obo:PR_000001255 obo:IAO_0000115 "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:60" ; oboInOwl:hasExactSynonym "C-C CKR-3", "CC-CKR-3", "CCR-3", "CCR3", "CD193", "CKR3", "MIP-1 alpha RL2", "chemokine receptor CCR3", "eosinophil eotaxin receptor", "macrophage inflammatory protein 1-alpha receptor-like 2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CMKBR3", "Cmkbr1l2" ; oboInOwl:id "PR:000001255" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "C-C chemokine receptor type 3" ; rdfs:subClassOf obo:PR_000001197 ; vocab:crossSpeciesExactMatch obo:PR_P51677 . obo:PR_000001281 obo:IAO_0000115 "A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267)." ; oboInOwl:hasDbXref "PIRSF:PIRSF005736" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001281" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "ADP-ribosyl cyclase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001289 obo:IAO_0000115 "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2628", "PIRSF:PIRSF001995" ; oboInOwl:hasExactSynonym "B-cell differentiation antigen Ly-44", "B-cell surface antigen CD20", "B-lymphocyte antigen CD20", "B-lymphocyte surface antigen B1", "Bp35", "MS4A1", "leukocyte surface antigen Leu-16", "lymphocyte antigen 44" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD20", "Ly-44", "Ms4a2" ; oboInOwl:id "PR:000001289" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "membrane-spanning 4-domains subfamily A member 1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001293 obo:IAO_0000115 "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD207", "langerin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CLEC4K" ; oboInOwl:id "PR:000001293" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "C-type lectin domain family 4 member K" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q9UJ71 . obo:PR_000001307 obo:IAO_0000115 "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD44", "CD44 antigen", "CDw44", "ECMR-III", "GP90 lymphocyte homing/adhesion receptor", "HUTCH-I", "PGP-1", "epican", "extracellular matrix receptor III", "heparan sulfate proteoglycan", "hermes antigen", "hyaluronate receptor", "ly-24", "lymphocyte antigen 24", "phagocytic glycoprotein 1", "phagocytic glycoprotein I" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "LHR", "MDU2", "MDU3", "MIC4", "PGP-I" ; oboInOwl:id "PR:000001307" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD44 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001308 obo:IAO_0000115 "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF001973" ; oboInOwl:hasExactSynonym "B-lymphocyte activation marker BLAST-1", "BCM1 surface antigen", "BLAST-1", "CD48", "CD48 antigen", "HM48-1", "MRC OX-45 surface antigen", "SLAM family member 2", "SLAMF2", "TCT.1", "leukocyte antigen MEM-102", "sgp-60", "signaling lymphocytic activation molecule 2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "BCM1", "BLAST1", "Bcm-1" ; oboInOwl:id "PR:000001308" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD48 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001318 obo:IAO_0000115 "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." ; oboInOwl:hasDbXref "PIRSF:PIRSF002421" ; oboInOwl:hasExactSynonym "CD62 antigen-like family member L", "CD62L", "LAM-1", "LECAM1", "SELL", "TQ1", "gp90-MEL", "leukocyte adhesion molecule 1", "leukocyte surface antigen Leu-8", "leukocyte-endothelial cell adhesion molecule 1", "ly-22", "lymph node homing receptor", "lymphocyte antigen 22", "lymphocyte surface MEL-14 antigen" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "LNHR", "LYAM1", "Ly22" ; oboInOwl:id "PR:000001318" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "L-selectin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P14151 . obo:PR_000001327 obo:IAO_0000115 "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." ; oboInOwl:hasDbXref "PIRSF:PIRSF002504" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001327" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "cadherin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001332 obo:IAO_0000115 "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD66b", "CD67 antigen", "CEACAM8", "carcinoembryonic antigen CGM6", "non-specific cross-reacting antigen NCA-95" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CGM6" ; oboInOwl:id "PR:000001332" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "carcinoembryonic antigen-related cell adhesion molecule 8" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P31997 . obo:PR_000001338 obo:IAO_0000115 "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF002484" ; oboInOwl:hasExactSynonym "CD21", "CR2", "Cr2", "EBV receptor", "complement C3d receptor", "epstein-Barr virus receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "C3DR" ; oboInOwl:id "PR:000001338" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "complement receptor type 2" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P20023 . obo:PR_000001343 obo:IAO_0000115 "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." ; oboInOwl:hasExactSynonym "AIM", "BL-AC/P26", "C-type lectin domain family 2 member C", "CD69", "EA1", "GP32/28", "MLR-3", "activation inducer molecule", "early T-cell activation antigen p60", "early activation antigen CD69", "leukocyte surface antigen Leu-23" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CLEC2C" ; oboInOwl:id "PR:000001343" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD69 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001344 obo:IAO_0000115 "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD203c", "E-NPP 3", "ENPP3", "PD-Ibeta", "ectonucleotide pyrophosphatase/phosphodiesterase 3", "phosphodiesterase I beta", "phosphodiesterase I/nucleotide pyrophosphatase 3" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "PDNP3" ; oboInOwl:id "PR:000001344" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "ectonucleotide pyrophosphatase/phosphodiesterase family member 3" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_O14638 . obo:PR_000001345 obo:IAO_0000115 "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2895", "PIRSF:PIRSF038746" ; oboInOwl:hasExactSynonym "CD105", "ENG", "cell surface MJ7/18 antigen" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "END", "Edg" ; oboInOwl:id "PR:000001345" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "endoglin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P17813 . obo:PR_000001352 obo:IAO_0000115 "A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." ; oboInOwl:hasDbXref "PIRSF:PIRSF002466" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001352" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "glycophorin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001355 obo:IAO_0000115 "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." ; oboInOwl:hasDbXref "PIRSF:PIRSF001980" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001355" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "immunoglobulin gamma Fc receptor II/III/IV" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001380 obo:IAO_0000115 "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "p55" ; oboInOwl:hasDbXref "IUPHARobj:1695", "PIRSF:PIRSF001954" ; oboInOwl:hasExactSynonym "CD25", "IL-2 receptor subunit alpha", "IL-2-RA", "IL-2R subunit alpha", "IL2-RA", "IL2RA", "TAC antigen" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Il2r" ; oboInOwl:id "PR:000001380" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "interleukin-2 receptor subunit alpha" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P01589 . obo:PR_000001381 obo:IAO_0000115 "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "p75" ; oboInOwl:hasDbXref "IUPHARobj:1696" ; oboInOwl:hasExactSynonym "CD122", "IL-2 receptor subunit beta", "IL-2R subunit beta", "IL-2RB", "IL2RB", "high affinity IL-2 receptor subunit beta", "p70-75" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IL15RB" ; oboInOwl:id "PR:000001381" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "interleukin-2 receptor subunit beta" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P14784 . obo:PR_000001403 obo:IAO_0000115 "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif." ; oboInOwl:hasDbXref "PIRSF:PIRSF002419" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001403" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "tetraspanin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001408 obo:IAO_0000115 "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2766" ; oboInOwl:hasExactSynonym "2'-phospho-ADP-ribosyl cyclase", "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase", "2'-phospho-cyclic-ADP-ribose transferase", "ADP-ribosyl cyclase 1", "ADPRC 1", "CD38", "I-19", "NIM-R5 antigen", "T10", "cADPr hydrolase 1", "cyclic ADP-ribose hydrolase 1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001408" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1" ; rdfs:subClassOf obo:PR_000001281 ; vocab:crossSpeciesExactMatch obo:PR_P28907 . obo:PR_000001444 obo:IAO_0000115 "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "7B4 antigen", "CD144", "CDH5", "VE-cadherin", "vascular endothelial cadherin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001444" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "cadherin-5" ; rdfs:subClassOf obo:PR_000001327 ; vocab:crossSpeciesExactMatch obo:PR_P33151 . obo:PR_000001460 obo:IAO_0000115 "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." ; oboInOwl:hasExactSynonym "CD235a", "GYPA", "MN sialoglycoprotein", "PAS-2", "sialoglycoprotein alpha" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GPA" ; oboInOwl:id "PR:000001460" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "glycophorin-A" ; rdfs:subClassOf obo:PR_000001352 ; vocab:crossSpeciesExactMatch obo:PR_P02724 . obo:PR_000001479 obo:IAO_0000115 "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "CD32" ; oboInOwl:hasExactSynonym "Fc gamma receptor IIB", "Fc-gamma RII", "Fc-gamma-RIIB", "FcRII", "Fcgr2", "IgG Fc receptor II beta", "ly-17", "lymphocyte antigen 17" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Fcgr2b" ; oboInOwl:id "PR:000001479" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "low affinity immunoglobulin gamma Fc region receptor II" ; rdfs:subClassOf obo:PR_000001355 . obo:PR_000001481 obo:IAO_0000115 "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "CD32", "CDw32" ; oboInOwl:hasExactSynonym "FCGR2B", "Fc-gamma RII-b", "Fc-gamma-RIIb", "FcRII-b", "IgG Fc receptor II-b" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "FCG2", "IGFR2" ; oboInOwl:id "PR:000001481" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "low affinity immunoglobulin gamma Fc region receptor II-b" ; rdfs:subClassOf obo:PR_000001355 ; vocab:crossSpeciesExactMatch obo:PR_P31994 . obo:PR_000001483 obo:IAO_0000115 "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD16", "Fc-gamma RIII", "FcRIII", "Fcgr3", "IgG Fc receptor III" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001483" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "low affinity immunoglobulin gamma Fc region receptor III" ; rdfs:subClassOf obo:PR_000001355 . obo:PR_000001785 obo:IAO_0000115 "A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." ; oboInOwl:hasDbXref "PANTHER:PTHR22730", "PIRSF:PIRSF017831" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001785" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "prominin" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001786 obo:IAO_0000115 "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD133", "PROM1", "antigen AC133", "antigen AC133 homolog", "prominin-like protein 1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "MSTP061", "PROML1", "Prom" ; oboInOwl:id "PR:000001786" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "prominin-1" ; rdfs:subClassOf obo:PR_000001785 ; vocab:crossSpeciesExactMatch obo:PR_O43490 . obo:PR_000001809 obo:IAO_0000115 "A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF038782" ; oboInOwl:hasExactSynonym "CD59-like" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001809" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues." ; rdfs:label "CD59-like glycoprotein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001810 obo:IAO_0000115 "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." ; oboInOwl:hasDbXref "PIRSF:PIRSF000615" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001810" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "CSF-1/PDGF receptor-type tyrosine-protein kinase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001813 obo:IAO_0000115 "An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:182", "PIRSF:PIRSF038685" ; oboInOwl:hasExactSynonym "ADGRE1", "EGF-like module receptor 1", "EGF-like module-containing mucin-like hormone receptor-like 1", "EMR1 hormone receptor", "cell surface glycoprotein F4/80" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "EMR1", "Gpf480", "TM7LN3" ; oboInOwl:id "PR:000001813" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "adhesion G protein-coupled receptor E1" ; rdfs:subClassOf obo:PR_000001087 ; vocab:crossSpeciesExactMatch obo:PR_Q14246 . obo:PR_000001832 obo:IAO_0000115 "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region." ; oboInOwl:hasDbXref "PIRSF:PIRSF038063" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001832" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "SIRP/SHPS-1 family protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001833 obo:IAO_0000115 "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD150", "CDw150", "IPO-3", "SLAMF1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SLAM" ; oboInOwl:id "PR:000001833" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "SLAM family member 1" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001836 obo:IAO_0000115 "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF038791" ; oboInOwl:hasExactSynonym "CD7", "GP40", "T-cell antigen CD7", "T-cell leukemia antigen", "T-cell surface antigen Leu-9", "TP41" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001836" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD7 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001839 obo:IAO_0000115 "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD5", "Lyt-1", "ly-1", "lymphocyte antigen 1", "lymphocyte antigen T1/Leu-1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "LEU1" ; oboInOwl:id "PR:000001839" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "T-cell surface glycoprotein CD5" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P06127 . obo:PR_000001843 obo:IAO_0000115 "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF038777" ; oboInOwl:hasExactSynonym "CD90", "CDw90", "THY1", "Thy-1 antigen" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Thy-1" ; oboInOwl:id "PR:000001843" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "Thy-1 membrane glycoprotein" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P04216 . obo:PR_000001858 obo:IAO_0000115 "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." ; oboInOwl:hasDbXref "PIRSF:PIRSF038787" ; oboInOwl:hasExactSynonym "CD179 antigen-like family member A", "CD179a", "V(pre)B protein", "VPREB1", "VpreB protein", "protein VPreB1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "VPREB" ; oboInOwl:id "PR:000001858" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "immunoglobulin iota chain" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P12018 . obo:PR_000001859 obo:IAO_0000115 "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD179 antigen-like family member B", "CD179b", "IGLL1", "Ig lambda-5", "immunoglobulin omega polypeptide", "immunoglobulin-related protein 14.1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IGL1", "Igl-5" ; oboInOwl:id "PR:000001859" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "immunoglobulin lambda-like polypeptide 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P15814 . obo:PR_000001861 obo:IAO_0000115 "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725)." ; oboInOwl:hasDbXref "PIRSF:PIRSF002512" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001861" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "integrin beta" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001865 obo:IAO_0000115 "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1705" ; oboInOwl:hasExactSynonym "CD123", "IL-3 receptor subunit alpha", "IL-3R subunit alpha", "IL-3R-alpha", "IL-3RA", "IL3RA", "interleukin-3 receptor class II alpha chain" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IL3R", "Sut-1" ; oboInOwl:id "PR:000001865" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "interleukin-3 receptor class 2 alpha chain" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001867 obo:IAO_0000115 "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1706", "PIRSF:PIRSF018419" ; oboInOwl:hasExactSynonym "CD125", "CDw125", "IL-5 receptor subunit alpha", "IL-5R subunit alpha", "IL-5R-alpha", "IL-5RA", "IL5RA" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IL5R" ; oboInOwl:id "PR:000001867" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "interleukin-5 receptor subunit alpha" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q01344 . obo:PR_000001869 obo:IAO_0000115 "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1698", "PIRSF:PIRSF001960" ; oboInOwl:hasExactSynonym "CD127", "CDw127", "IL-7 receptor subunit alpha", "IL-7R subunit alpha", "IL-7R-alpha", "IL-7RA", "IL7R" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001869" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "interleukin-7 receptor subunit alpha" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P16871 . obo:PR_000001874 obo:IAO_0000115 "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." ; oboInOwl:hasDbXref "PIRSF:PIRSF038804" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001874" ; a owl:Class ; rdfs:comment "Category=family. Requested by=CL." ; rdfs:label "KLRB1-like protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001879 obo:IAO_0000115 "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF001994" ; oboInOwl:hasExactSynonym "B-cell differentiation antigen LP-3", "GALGP", "SPN", "galactoglycoprotein", "leukocyte sialoglycoprotein", "ly-48", "lymphocyte antigen 48", "sialophorin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD43" ; oboInOwl:id "PR:000001879" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "leukosialin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P16150 . obo:PR_000001880 obo:IAO_0000115 "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2935", "PIRSF:PIRSF002426" ; oboInOwl:hasExactSynonym "BLAST-2", "C-type lectin domain family 4 member J", "CD23", "FCER2", "Fc-epsilon-RII", "immunoglobulin E-binding factor", "lymphocyte IgE receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD23A", "CLEC4J", "FCE2", "Fcer2a", "IGEBF" ; oboInOwl:id "PR:000001880" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "low affinity immunoglobulin epsilon Fc receptor" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P06734 . obo:PR_000001883 obo:IAO_0000115 "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." ; oboInOwl:hasDbXref "PIRSF:PIRSF002462" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001883" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "lysosome-associated membrane protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001888 obo:IAO_0000115 "A protein with core architecture consisting of a Peptidase family M1 domain (Pfam:PF01433)." ; oboInOwl:hasDbXref "PIRSF:PIRSF005502" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001888" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "membrane alanyl aminopeptidase-like metallopeptidase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001889 obo:IAO_0000115 "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF002017" ; oboInOwl:hasExactSynonym "CD14", "monocyte differentiation antigen CD14", "myeloid cell-specific leucine-rich glycoprotein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001889" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD14 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001892 obo:IAO_0000115 "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2601" ; oboInOwl:hasExactSynonym "CD33", "gp67", "myeloid cell surface antigen CD33", "sialic acid-binding Ig-like lectin 3", "siglec-3" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SIGLEC3" ; oboInOwl:id "PR:000001892" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD33 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001896 obo:IAO_0000115 "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD244", "NAIL", "NK cell activation-inducing ligand", "NK cell type I receptor protein 2B4", "NKR2B4", "SLAM family member 4", "SLAMF4", "non-MHC restricted killing associated", "signaling lymphocytic activation molecule 4" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "2B4", "Nmrk" ; oboInOwl:id "PR:000001896" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "natural killer cell receptor 2B4" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q9BZW8 . obo:PR_000001898 obo:IAO_0000115 "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1611", "PIRSF:PIRSF501074" ; oboInOwl:hasExactSynonym "CALLA", "CD10", "MME", "NEP", "SFE", "atriopeptidase", "common acute lymphocytic leukemia antigen", "enkephalinase", "neutral endopeptidase", "neutral endopeptidase 24.11", "skin fibroblast elastase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "EPN" ; oboInOwl:id "PR:000001898" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "neprilysin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P08473 . obo:PR_000001903 obo:IAO_0000115 "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "B-cell-specific transcription factor", "BSAP", "PAX5" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Pax-5" ; oboInOwl:id "PR:000001903" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "paired box protein PAX-5" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q02548 . obo:PR_000001919 obo:IAO_0000115 "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2760", "PIRSF:PIRSF018380" ; oboInOwl:hasExactSynonym "CD279", "PD-1", "PDCD1", "protein PD-1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "PD1" ; oboInOwl:id "PR:000001919" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "programmed cell death protein 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q15116 . obo:PR_000001925 obo:IAO_0000115 "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD163", "hemoglobin scavenger receptor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "M130" ; oboInOwl:id "PR:000001925" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "scavenger receptor cysteine-rich type 1 protein M130" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q86VB7 . obo:PR_000001932 obo:IAO_0000115 "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD24", "HSA", "M1/69-J11D heat stable antigen", "R13-Ag", "X62 heat stable antigen", "ly-52", "lymphocyte antigen 52", "nectadrin", "small cell lung carcinoma cluster 4 antigen" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD24A" ; oboInOwl:id "PR:000001932" ; a owl:Class ; rdfs:comment "Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL." ; rdfs:label "signal transducer CD24" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P25063 . obo:PR_000001935 obo:IAO_0000115 "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF015854" ; oboInOwl:hasExactSynonym "CD138", "SDC1", "SYND1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SDC", "Synd-1" ; oboInOwl:id "PR:000001935" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "syndecan-1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P18827 . obo:PR_000001938 obo:IAO_0000115 "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." ; oboInOwl:hasDbXref "PIRSF:PIRSF001775" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001938" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "thrombomodulin-like receptor" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001944 obo:IAO_0000115 "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "31 kDa-transforming protein", "SFFV proviral integration 1 protein", "SPI1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Sfpi-1", "Sfpi1" ; oboInOwl:id "PR:000001944" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "transcription factor PU.1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P17947 . obo:PR_000001945 obo:IAO_0000115 "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "p90" ; oboInOwl:hasExactSynonym "CD71", "T9", "TFRC", "TfR", "TfR1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "TR", "Trfr" ; oboInOwl:id "PR:000001945" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "transferrin receptor protein 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P02786 . obo:PR_000001950 obo:IAO_0000115 "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "TRAP" ; oboInOwl:hasDbXref "PIRSF:PIRSF016527" ; oboInOwl:hasExactSynonym "CD154", "CD40-L", "CD40LG", "T-cell antigen Gp39", "TNF-related activation protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD40L", "TNFSF5" ; oboInOwl:id "PR:000001950" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "tumor necrosis factor ligand superfamily member 5" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001963 obo:IAO_0000115 "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1876", "PIRSF:PIRSF001966" ; oboInOwl:hasExactSynonym "CD27", "CD27L receptor", "T-cell activation antigen CD27", "tumor necrosis factor receptor superfamily member 7" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "T14", "TNFRSF7" ; oboInOwl:id "PR:000001963" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD27 molecule" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000001968 obo:IAO_0000115 "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "p84" ; oboInOwl:hasDbXref "IUPHARobj:2942" ; oboInOwl:hasExactSynonym "Bit", "CD172 antigen-like family member A", "CD172a", "MyD-1 antigen", "SHP substrate 1", "SHPS-1", "SIRPA", "Sirp-alpha-1", "Sirp-alpha-2", "Sirp-alpha-3", "brain Ig-like molecule with tyrosine-based activation motifs", "inhibitory receptor SHPS-1", "macrophage fusion receptor", "signal-regulatory protein alpha-1", "signal-regulatory protein alpha-2", "signal-regulatory protein alpha-3" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "BIT", "MFR", "MYD1", "PTPNS1", "SHPS1", "SIRP" ; oboInOwl:id "PR:000001968" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "tyrosine-protein phosphatase non-receptor type substrate 1" ; rdfs:subClassOf obo:PR_000001832 ; vocab:crossSpeciesExactMatch obo:PR_P78324 . obo:PR_000001969 obo:IAO_0000115 "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "PIRSF:PIRSF002022" ; oboInOwl:hasExactSynonym "CD87", "PLAUR", "U-PAR", "monocyte activation antigen Mo3", "uPAR" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "MO3", "UPAR" ; oboInOwl:id "PR:000001969" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "urokinase plasminogen activator surface receptor" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q03405 . obo:PR_000001971 obo:IAO_0000115 "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." ; oboInOwl:hasDbXref "PIRSF:PIRSF038502" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000001971" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "vascular endothelial growth factor receptor" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000002001 obo:IAO_0000115 "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1807", "PIRSF:PIRSF500949" ; oboInOwl:hasExactSynonym "FL cytokine receptor", "FLK-2", "FLT-3", "FLT3", "Fms-like tyrosine kinase 3", "fetal liver kinase 2", "stem cell tyrosine kinase 1", "tyrosine-protein kinase FLT3", "tyrosine-protein kinase receptor FLT3", "tyrosine-protein kinase receptor flk-2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CD135", "FLK2", "STK-1", "STK1" ; oboInOwl:id "PR:000002001" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "receptor-type tyrosine-protein kinase FLT3" ; rdfs:subClassOf obo:PR_000001810 ; vocab:crossSpeciesExactMatch obo:PR_P36888 . obo:PR_000002037 obo:IAO_0000115 "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "C1q/MBL/SPA receptor", "C1qR", "C1qR(p)", "C1qRp", "CD93", "CDw93", "Ly-68", "cell surface antigen AA4", "complement component 1 q subcomponent receptor 1", "lymphocyte antigen 68", "matrix-remodeling-associated protein 4" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Aa4", "C1QR1", "Ly68", "MXRA4" ; oboInOwl:id "PR:000002037" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "complement component C1q receptor" ; rdfs:subClassOf obo:PR_000001938 ; vocab:crossSpeciesExactMatch obo:PR_Q9NPY3 . obo:PR_000002039 obo:IAO_0000115 "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1568" ; oboInOwl:hasExactSynonym "AP-A", "BP-1/6C3 antigen", "CD249", "ENPEP", "aminopeptidase A", "differentiation antigen gp160" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "EAP" ; oboInOwl:id "PR:000002039" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "glutamyl aminopeptidase" ; rdfs:subClassOf obo:PR_000001888 ; vocab:crossSpeciesExactMatch obo:PR_Q07075 . obo:PR_000002062 obo:IAO_0000115 "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1806", "PIRSF:PIRSF500947" ; oboInOwl:hasExactSynonym "CD115", "CSF-1 receptor", "CSF-1-R", "CSF-1R", "CSF1R", "M-CSF-R", "proto-oncogene c-Fms" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Csfmr", "FMS" ; oboInOwl:id "PR:000002062" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "macrophage colony-stimulating factor 1 receptor" ; rdfs:subClassOf obo:PR_000001810 ; vocab:crossSpeciesExactMatch obo:PR_P07333 . obo:PR_000002064 obo:IAO_0000115 "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD68" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "gp110" ; oboInOwl:id "PR:000002064" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "macrosialin" ; rdfs:subClassOf obo:PR_000001883 ; vocab:crossSpeciesExactMatch obo:PR_P34810 . obo:PR_000002065 obo:IAO_0000115 "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1805", "PIRSF:PIRSF500951" ; oboInOwl:hasExactSynonym "CD117", "KIT", "proto-oncogene c-Kit", "tyrosine-protein kinase Kit" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SCFR", "Sl" ; oboInOwl:id "PR:000002065" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "mast/stem cell growth factor receptor" ; rdfs:subClassOf obo:PR_000001810 . obo:PR_000002112 obo:IAO_0000115 "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1813" ; oboInOwl:hasExactSynonym "CD309", "FLK-1", "KDR", "VEGFR-2", "fetal liver kinase 1", "kinase NYK", "kinase insert domain receptor", "protein-tyrosine kinase receptor flk-1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "FLK1", "VEGFR2" ; oboInOwl:id "PR:000002112" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "vascular endothelial growth factor receptor 2" ; rdfs:subClassOf obo:PR_000001971 ; vocab:crossSpeciesExactMatch obo:PR_P35968 . obo:PR_000002976 obo:IAO_0000115 "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." ; oboInOwl:hasDbXref "PIRSF:PIRSF002021" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000002976" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "Ly-6-like protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000002977 obo:IAO_0000115 "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD161 antigen-like family member C", "CD161c", "Klrb1c", "NK1.1", "NKR-P1 40", "NKR-P1.9", "NKR-P1C", "ly-55c", "lymphocyte antigen 55c", "natural killer cell surface protein P1-40" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Ly55c", "Nkrp1c" ; oboInOwl:id "PR:000002977" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "killer cell lectin-like receptor subfamily B member 1C" ; rdfs:subClassOf obo:PR_000001874 . obo:PR_000002978 obo:IAO_0000115 "An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "Ly-6G", "Ly-6G.1", "Ly6g" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000002978" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "lymphocyte antigen 6G" ; rdfs:subClassOf obo:PR_000002976 . obo:PR_000002979 obo:IAO_0000115 "An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "Ly-6A.2/Ly-6E.1", "Ly6a", "T-cell-activating protein", "stem cell antigen 1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Ly6", "SCA-1", "TAP" ; oboInOwl:id "PR:000002979" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "lymphocyte antigen 6A-2/6E-1" ; rdfs:subClassOf obo:PR_000002976 . obo:PR_000002980 obo:IAO_0000115 "An Ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "Ly-6C2", "Ly6c2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Ly6c" ; oboInOwl:id "PR:000002980" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "lymphocyte antigen 6C2" ; rdfs:subClassOf obo:PR_000002976 . obo:PR_000002981 obo:IAO_0000115 "A protein that is a translation product of the Ly76 gene in mouse." ; oboInOwl:hasExactSynonym "mLy76", "ter-119", "ter119" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000002981" ; a owl:Class ; rdfs:comment "Category=organism-gene. Requested by=CL." ; rdfs:label "lymphocyte antigen 76 (mouse)" ; rdfs:subClassOf obo:PR_000029032 . obo:PR_000003457 obo:IAO_0000115 "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "RAG-1", "RAG1", "RING finger protein 74" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "RNF74" ; oboInOwl:id "PR:000003457" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "V(D)J recombination-activating protein 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P15918 . obo:PR_000003460 obo:IAO_0000115 "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "RAG-2", "RAG2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000003460" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "V(D)J recombination-activating protein 2" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P55895 . obo:PR_000003516 obo:IAO_0000115 "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "alpha-1,4-N-acetylglucosaminyltransferase" ; oboInOwl:hasExactSynonym "A4GALT", "CD77 synthase", "Gb3 synthase", "P1/Pk synthase", "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase", "alpha-1,4-galactosyltransferase", "alpha4Gal-T1", "globotriaosylceramide synthase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "A14GALT", "A4GALT1" ; oboInOwl:id "PR:000003516" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "lactosylceramide 4-alpha-galactosyltransferase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q9NPC4 . obo:PR_000003777 obo:IAO_0000115 "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "30 kDa adipocyte complement-related protein", "ADIPOQ", "adipocyte complement-related 30 kDa protein", "adipocyte, C1q and collagen domain-containing protein", "adipocyte-specific protein AdipoQ", "adipose most abundant gene transcript 1 protein", "apM-1", "gelatin-binding protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "ACDC", "ACRP30", "APM1", "GBP28" ; oboInOwl:id "PR:000003777" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "adiponectin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q15848 . obo:PR_000003809 obo:IAO_0000115 "A protein that is a translation product of the human AFP gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "AFP", "alpha-1-fetoprotein", "alpha-fetoglobulin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "HPAFP" ; oboInOwl:id "PR:000003809" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "alpha-fetoprotein" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P02771 . obo:PR_000003918 obo:IAO_0000115 "A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "ALB", "serum albumin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Alb-1", "Alb1", "GIG20", "GIG42", "PRO0903", "PRO1708", "PRO2044", "PRO2619", "PRO2675", "UNQ696/PRO1341" ; oboInOwl:id "PR:000003918" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "albumin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P02768 . obo:PR_000003964 obo:IAO_0000115 "A protein that is a translation product of the human ALPI gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "ALPI" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IAP" ; oboInOwl:id "PR:000003964" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "intestinal alkaline phosphatase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000003968 obo:IAO_0000115 "A protein that is a translation product of the human ALPL gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "ALPL", "AP-TNAP", "TNSALP", "alkaline phosphatase 2", "alkaline phosphatase liver/bone/kidney isozyme", "phosphoamidase", "phosphocreatine phosphatase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Akp-2", "Akp2" ; oboInOwl:id "PR:000003968" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "alkaline phosphatase, tissue-nonspecific isozyme" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P05186 . obo:PR_000003969 obo:IAO_0000115 "A protein that is a translation product of the human ALPP gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "ALPP", "PLAP-1", "alkaline phosphatase Regan isozyme", "placental alkaline phosphatase 1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "PLAP" ; oboInOwl:id "PR:000003969" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "alkaline phosphatase, placental type" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P05187 . obo:PR_000004089 obo:IAO_0000115 "A protein that is a translation product of the human AOX1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "AOX1", "retinal oxidase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "AO", "Ro" ; oboInOwl:id "PR:000004089" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "aldehyde oxidase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q06278 . obo:PR_000005061 obo:IAO_0000115 "A protein that is a translation product of the human CAT gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CAT" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Cas-1", "Cas1" ; oboInOwl:id "PR:000005061" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "catalase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P04040 . obo:PR_000005178 obo:IAO_0000115 "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "p24" ; oboInOwl:hasExactSynonym "5H9 antigen", "CD9", "CD9 antigen", "MRP-1", "cell growth-inhibiting gene 2 protein", "leukocyte antigen MIC3", "motility-related protein", "tetraspanin-29", "tspan-29" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GIG2", "MIC3", "TSPAN29" ; oboInOwl:id "PR:000005178" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CD9 molecule" ; rdfs:subClassOf obo:PR_000001403 . obo:PR_000005307 obo:IAO_0000115 "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "C/EBP alpha", "CEBPA" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CEBP" ; oboInOwl:id "PR:000005307" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "CCAAT/enhancer-binding protein alpha" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P49715 . obo:PR_000005794 obo:IAO_0000115 "A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CP", "ferroxidase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000005794" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "ceruloplasmin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P00450 . obo:PR_000006169 obo:IAO_0000115 "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD200 cell surface glycoprotein receptor-like 3", "CD200 cell surface glycoprotein receptor-like b", "CD200 receptor-like 3", "CD200RLb", "Cd200r3", "cell surface glycoprotein OX2 receptor 3" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000006169" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "cell surface glycoprotein CD200 receptor 3" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000006611 obo:IAO_0000115 "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "DNTT", "terminal addition enzyme", "terminal deoxynucleotidyltransferase", "terminal transferase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "TDT" ; oboInOwl:id "PR:000006611" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "DNA nucleotidylexotransferase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P04053 . obo:PR_000006678 obo:IAO_0000115 "A protein that is a translation product of the human DPYD gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "DPD", "dihydrothymine dehydrogenase", "dihydrouracil dehydrogenase" ; oboInOwl:hasExactSynonym "DHPDHase", "DPYD" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000006678" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "dihydropyrimidine dehydrogenase [NADP(+)]" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q12882 . obo:PR_000007431 obo:IAO_0000115 "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2933" ; oboInOwl:hasExactSynonym "FCER1A", "Fc-epsilon RI-alpha", "IgE Fc receptor subunit alpha" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "FCE1A", "FcERI" ; oboInOwl:id "PR:000007431" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "high affinity immunoglobulin epsilon receptor subunit alpha" ; rdfs:subClassOf obo:PR_000001355 ; vocab:crossSpeciesExactMatch obo:PR_P12319 . obo:PR_000007499 obo:IAO_0000115 "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "FGF-8", "FGF8", "androgen-induced growth factor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "AIGF", "HBGF-8", "heparin-binding growth factor 8" ; oboInOwl:id "PR:000007499" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "fibroblast growth factor 8" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P55075 . obo:PR_000007636 obo:IAO_0000115 "A protein that is a translation product of the human FOXN1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2958" ; oboInOwl:hasExactSynonym "FOXN1", "HNF-3/forkhead homolog 11", "winged-helix transcription factor nude" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Fkh19", "HFH-11", "Hfh11", "RONU", "WHN", "hepatocyte nuclear factor 3 forkhead homolog 11" ; oboInOwl:id "PR:000007636" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "forkhead box protein N1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_O15353 . obo:PR_000007749 obo:IAO_0000115 "A glucose-6-phosphate dehydrogenase that is a translation product of the human G6PD gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "G6PD", "glucose-6-phosphate 1-dehydrogenase X" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "G6pd-1", "G6pdx" ; oboInOwl:id "PR:000007749" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "glucose-6-phosphate 1-dehydrogenase" ; rdfs:subClassOf obo:PR_000050060 ; vocab:crossSpeciesExactMatch obo:PR_P11413 . obo:PR_000007812 obo:IAO_0000115 "A protein that is a translation product of the human GALE gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GALE", "UDP-GalNAc 4-epimerase", "UDP-GlcNAc 4-epimerase", "UDP-N-acetylglucosamine 4-epimerase", "galactowaldenase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "UDP-galactose 4-epimerase" ; oboInOwl:id "PR:000007812" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "UDP-glucose 4-epimerase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q14376 . obo:PR_000007856 obo:IAO_0000115 "A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GAST" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GAS" ; oboInOwl:id "PR:000007856" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "gastrin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P01350 . obo:PR_000007857 obo:IAO_0000115 "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "Eryf1", "GATA-1", "GATA-binding factor 1", "GATA1", "NF-E1 DNA-binding protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "ERYF1", "GF-1", "GF1" ; oboInOwl:id "PR:000007857" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "erythroid transcription factor" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P15976 . obo:PR_000007858 obo:IAO_0000115 "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GATA-binding protein 2", "GATA2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000007858" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "endothelial transcription factor GATA-2" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P23769 . obo:PR_000007891 obo:IAO_0000115 "A protein that is a translation product of the human GCG gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GCG" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000007891" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "pro-glucagon" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P01275 . obo:PR_000007939 obo:IAO_0000115 "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GFAP" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000007939" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "glial fibrillary acidic protein" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P14136 . obo:PR_000007975 obo:IAO_0000115 "A protein that is a translation product of the human CBLIF gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CBLIF", "IF", "INF", "gastric intrinsic factor", "intrinsic factor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GIF", "IFMH" ; oboInOwl:id "PR:000007975" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "cobalamin binding intrinsic factor" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P27352 . obo:PR_000008175 obo:IAO_0000115 "A protein that is a translation product of the human GPI gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "NLK" ; oboInOwl:hasExactSynonym "AMF", "GPI", "PGI", "PHI", "SA-36", "autocrine motility factor", "neuroleukin", "phosphoglucose isomerase", "phosphohexose isomerase", "sperm antigen 36" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Gpi1" ; oboInOwl:id "PR:000008175" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "glucose-6-phosphate isomerase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P06744 . obo:PR_000008730 obo:IAO_0000115 "A protein that is a translation product of the human HPD gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2621" ; oboInOwl:hasExactSynonym "4-hydroxyphenylpyruvic acid oxidase", "4HPPD", "F Alloantigen", "F protein", "HPD", "HPPDase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "PPD" ; oboInOwl:id "PR:000008730" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "4-hydroxyphenylpyruvate dioxygenase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P32754 . obo:PR_000008894 obo:IAO_0000115 "A protein that is a translation product of the human IDS gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "IDS", "alpha-L-iduronate sulfate sulfatase", "idursulfase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "SIDS" ; oboInOwl:id "PR:000008894" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "iduronate 2-sulfatase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P22304 . obo:PR_000009054 obo:IAO_0000115 "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." ; oboInOwl:hasBroadSynonym "insulin" ; oboInOwl:hasExactSynonym "INS" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000009054" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "insulin gene translation product" ; rdfs:subClassOf obo:PR_000045358 ; vocab:crossSpeciesExactMatch obo:PR_P01308 . obo:PR_000009127 obo:IAO_0000115 "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2441" ; oboInOwl:hasExactSynonym "CD41", "GPIIb", "GPalpha IIb", "ITGA2B", "platelet membrane glycoprotein IIb" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GP2B", "ITGAB" ; oboInOwl:id "PR:000009127" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "integrin alpha-IIb" ; rdfs:subClassOf obo:PR_000025797 ; vocab:crossSpeciesExactMatch obo:PR_P08514 . obo:PR_000009143 obo:IAO_0000115 "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2461" ; oboInOwl:hasExactSynonym "Gut homing receptor beta subunit", "ITGB7", "M290 IEL antigen", "integrin beta-P" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000009143" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "integrin beta-7" ; rdfs:subClassOf obo:PR_000001861 ; vocab:crossSpeciesExactMatch obo:PR_P26010 . obo:PR_000009758 obo:IAO_0000115 "A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "LEP", "obese protein", "obesity factor" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "OB", "OBS" ; oboInOwl:id "PR:000009758" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "leptin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P41159 . obo:PR_000009771 obo:IAO_0000115 "A protein that is a translation product of the human LGALS3 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "35 kDa lectin", "CBP 35", "GALBP", "IgE-binding protein", "L-31", "L-34 galactoside-binding lectin", "LGALS3", "Mac-2 antigen", "carbohydrate-binding protein 35", "gal-3", "galactose-specific lectin 3", "galactoside-binding protein", "laminin-binding protein", "lectin L-29" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "MAC2" ; oboInOwl:id "PR:000009771" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "galectin-3" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P17931 . obo:PR_000009978 obo:IAO_0000115 "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "LTF", "lactoferrin", "talalactoferrin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "GIG12", "LF" ; oboInOwl:id "PR:000009978" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "lactotransferrin" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P02788 . obo:PR_000010379 obo:IAO_0000115 "A protein that is a translation product of the human MGAT2 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "GNT-II", "GlcNAc-T II", "MGAT2", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II", "beta-1,2-N-acetylglucosaminyltransferase II", "mannoside acetylglucosaminyltransferase 2" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000010379" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q10469 . obo:PR_000011649 obo:IAO_0000115 "A protein that is a translation product of the human OPLAH gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "5-OPase", "5-oxo-L-prolinase", "OPLAH", "pyroglutamase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000011649" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "5-oxoprolinase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_O14841 . obo:PR_000012234 obo:IAO_0000115 "A protein that is a translation product of the human PAH gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:1240" ; oboInOwl:hasExactSynonym "PAH", "Phe-4-monooxygenase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000012234" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "phenylalanine-4-hydroxylase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P00439 . obo:PR_000013246 obo:IAO_0000115 "A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "PRL" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000013246" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "prolactin" ; rdfs:subClassOf obo:PR_000029968 ; vocab:crossSpeciesExactMatch obo:PR_P01236 . obo:PR_000013429 obo:IAO_0000115 "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "PTH", "parathormone", "parathyrin" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000013429" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "parathyroid hormone" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P01270 . obo:PR_000013883 obo:IAO_0000115 "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2413" ; oboInOwl:hasExactSynonym "REN" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "angiotensinogenase" ; oboInOwl:id "PR:000013883" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "renin" ; rdfs:subClassOf obo:PR_000050025 ; vocab:crossSpeciesExactMatch obo:PR_P00797 . obo:PR_000014841 obo:IAO_0000115 "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "HHG-1", "SHH", "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains", "ShhNC" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "Hhg1" ; oboInOwl:id "PR:000014841" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "sonic hedgehog protein" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q15465 . obo:PR_000016043 obo:IAO_0000115 "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "T-cell leukemia/lymphoma protein 5", "TAL-1", "TAL1", "bHLHa17", "class A basic helix-loop-helix protein 17", "stem cell protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "BHLHA17", "SCL", "TCL5" ; oboInOwl:id "PR:000016043" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "T-cell acute lymphocytic leukemia protein 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P17542 . obo:PR_000016401 obo:IAO_0000115 "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "TMED1", "interleukin-1 receptor-like 1 ligand", "p24 family protein gamma-1", "p24gamma1", "putative T1/ST2 receptor-binding protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "IL1RL1L", "IL1RL1LG" ; oboInOwl:id "PR:000016401" ; a owl:Class ; rdfs:comment "Category=gene. Requested by=CL." ; rdfs:label "transmembrane emp24 domain-containing protein 1" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_Q13445 . obo:PR_000017364 obo:IAO_0000115 "A protein that is a translation product of the human VWF gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "VWF", "vWF" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "F8VWF" ; oboInOwl:id "PR:000017364" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "von Willebrand factor" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P04275 . obo:PR_000017477 obo:IAO_0000115 "A protein that is a translation product of the human XDH gene or a 1:1 ortholog thereof." ; oboInOwl:hasDbXref "IUPHARobj:2646" ; oboInOwl:hasExactSynonym "XDH" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "XDHA" ; oboInOwl:id "PR:000017477" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "xanthine dehydrogenase/oxidase" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_P47989 . obo:PR_000018263 obo:IAO_0000115 "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." ; oboInOwl:hasNarrowSynonym "peptide", "polypeptide" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018263" ; a owl:Class ; rdfs:comment "Category=polymer." ; rdfs:label "amino acid chain" ; rdfs:subClassOf obo:CHEBI_50047, [ a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:CHEBI_33708 ; owl:onProperty pr:has_constituent_monomer ] . obo:PR_000018264 obo:IAO_0000115 "A protein that is produced as the result of proteolytic processing of a longer protein." ; oboInOwl:hasExactSynonym "ClvPrd" ; oboInOwl:hasNarrowSynonym "peptide", "polypeptide" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018264" ; a owl:Class ; rdfs:label "proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000000001, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018335 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." ; oboInOwl:hasExactSynonym "CD8A/SigPep-" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018335" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form" ; rdfs:subClassOf obo:PR_000001084 . obo:PR_000018337 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed." ; oboInOwl:hasExactSynonym "CD8B/SigPep-" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018337" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 beta chain, signal peptide removed form" ; rdfs:subClassOf obo:PR_000001085 . obo:PR_000018381 obo:IAO_0000115 "A CD48 molecule that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "CD48/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018381" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "CD48 molecule proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001308, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001308 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018390 obo:IAO_0000115 "An L-selectin that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "SELL/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018390" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "L-selectin proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001318, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001318 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018406 obo:IAO_0000115 "A carcinoembryonic antigen-related cell adhesion molecule 8 that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "CEACAM8/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018406" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "carcinoembryonic antigen-related cell adhesion molecule 8 proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001332, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001332 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018546 obo:IAO_0000115 "A Thy-1 membrane glycoprotein that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "THY1/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018546" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "Thy-1 membrane glycoprotein proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001843, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001843 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018568 obo:IAO_0000115 "A low affinity immunoglobulin epsilon Fc receptor that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "FCER2/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018568" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "low affinity immunoglobulin epsilon Fc receptor proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001880, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001880 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018594 obo:IAO_0000115 "A scavenger receptor cysteine-rich type 1 protein M130 that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "CD163/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018594" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "scavenger receptor cysteine-rich type 1 protein M130 proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001925, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001925 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018603 obo:IAO_0000115 "A transferrin receptor protein 1 that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "TFRC/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018603" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "transferrin receptor protein 1 proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001945, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001945 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018606 obo:IAO_0000115 "A tumor necrosis factor ligand superfamily member 5 that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "CD40LG/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018606" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "tumor necrosis factor ligand superfamily member 5 proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001950, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001950 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018950 obo:IAO_0000115 "An albumin that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "ALB/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018950" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "albumin proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000003918, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000003918 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000018969 obo:IAO_0000115 "An alkaline phosphatase, placental type that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "ALPP/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000018969" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "alkaline phosphatase, placental type proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000003969, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000003969 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000019705 obo:IAO_0000115 "A dihydropyrimidine dehydrogenase [NADP(+)] that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "DPYD/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000019705" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "dihydropyrimidine dehydrogenase [NADP(+)] proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000006678, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000006678 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000019973 obo:IAO_0000115 "A gastrin that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "GAST/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000019973" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "gastrin proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000007856, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000007856 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000019980 obo:IAO_0000115 "A pro-glucagon that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "GCG/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000019980" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "pro-glucagon proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000007891, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000007891 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000020230 obo:IAO_0000115 "An iduronate 2-sulfatase that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "IDS/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000020230" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "iduronate 2-sulfatase proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000008894, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000008894 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000020329 obo:IAO_0000115 "An integrin alpha-IIb that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "ITGA2B/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000020329" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "integrin alpha-IIb proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000009127, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000009127 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000020497 obo:IAO_0000115 "A lactotransferrin that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "LTF/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000020497" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "lactotransferrin proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000009978, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000009978 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000021170 obo:IAO_0000115 "A parathyroid hormone that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "PTH/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000021170" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "parathyroid hormone proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000013429, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000013429 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000021468 obo:IAO_0000115 "A sonic hedgehog protein that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "SHH/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000021468" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "sonic hedgehog protein proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000014841, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000014841 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000021841 obo:IAO_0000115 "A von Willebrand factor that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "VWF/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000021841" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "von Willebrand factor proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000017364, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000017364 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000023661 obo:IAO_0000115 "A protein that is a translation product of the Escherichia coli K-12 pyrF gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "OMP decarboxylase", "OMPDCase", "OMPdecase", "pyrF" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000023661" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "orotidine 5'-phosphate decarboxylase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025402 obo:IAO_0000115 "A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." ; oboInOwl:hasExactSynonym "CD8alphabeta", "TCR co-receptor CD8" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025402" ; a owl:Class ; rdfs:comment "Category=complex. Requested by=CL." ; rdfs:label "T cell receptor co-receptor CD8" ; rdfs:subClassOf obo:GO_0032991, [ a owl:Restriction ; owl:onProperty obo:RO_0002180 ; owl:someValuesFrom obo:PR_000025408 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002180 ; owl:someValuesFrom obo:PR_000025409 ] . obo:PR_000025403 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." ; oboInOwl:hasExactSynonym "CD8A/iso:1", "mCD8alpha" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025403" ; a owl:Class ; rdfs:comment "Category=sequence. Requested by=CL." ; rdfs:label "T-cell surface glycoprotein CD8 alpha chain isoform 1" ; rdfs:subClassOf obo:PR_000001084 ; vocab:crossSpeciesExactMatch obo:PR_P01732-1 . obo:PR_000025405 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CD8B/iso:1", "CD8beta isoform M-1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025405" ; a owl:Class ; rdfs:comment "Category=sequence." ; rdfs:label "T-cell surface glycoprotein CD8 beta chain isoform 1" ; rdfs:subClassOf obo:PR_000001085 . obo:PR_000025406 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." ; oboInOwl:hasExactSynonym "CD8A/iso:1/SigPep-" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025406" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form" ; rdfs:subClassOf obo:PR_000018335, obo:PR_000025403 . obo:PR_000025407 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form." ; oboInOwl:hasExactSynonym "CD8B/iso:1/SigPep-" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025407" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form" ; rdfs:subClassOf obo:PR_000018337, obo:PR_000025405 . obo:PR_000025408 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." ; oboInOwl:hasExactSynonym "CD8A/iso:1/SigPep-/GlycoRes+" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025408" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form" ; rdfs:subClassOf obo:PR_000025406, obo:PR_000037069 . obo:PR_000025409 obo:IAO_0000115 "A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." ; oboInOwl:hasExactSynonym "CD8B/iso:1/SigPep-/GlycoRes+" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025409" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form" ; rdfs:subClassOf obo:PR_000025407, obo:PR_000037069 . obo:PR_000025455 obo:IAO_0000115 "A CD2 molecule that has been processed by proteolytic cleavage." ; oboInOwl:hasExactSynonym "CD2/ClvPrd" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025455" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "CD2 molecule proteolytic cleavage product" ; rdfs:subClassOf obo:PR_000001083, obo:PR_000018264, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000001083 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0016485 ] ) ] . obo:PR_000025796 obo:IAO_0000115 "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025796" ; a owl:Class ; rdfs:comment "Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]." ; rdfs:label "integrin alpha" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000025797 obo:IAO_0000115 "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." ; oboInOwl:hasDbXref "PIRSF:PIRSF005666" ; oboInOwl:hasExactSynonym "fam:ITGAsansA" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000025797" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "integrin alpha lacking A domain" ; rdfs:subClassOf obo:PR_000025796 . obo:PR_000027222 obo:IAO_0000115 "A protein that is a translation product of the human CALCA gene or a 1:1 ortholog thereof." ; oboInOwl:hasExactSynonym "CALCA" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CALC" ; oboInOwl:id "PR:000027222" ; a owl:Class ; rdfs:comment "Category=gene." ; rdfs:label "CALCA gene translation product" ; rdfs:subClassOf obo:PR_000000001 ; vocab:crossSpeciesExactMatch obo:PR_000030026 . obo:PR_000028527 obo:IAO_0000115 "A proteolytic cleavage product that is derived from any of the casein milk proteins." ; oboInOwl:hasExactSynonym "CN (f)" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000028527" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "casein derived peptide" ; rdfs:subClassOf obo:PR_000018264 . obo:PR_000029032 obo:IAO_0000115 "A protein that is encoded in the genome of Mus musculus." ; oboInOwl:hasExactSynonym "mouse protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000029032" ; a owl:Class ; rdfs:label "Mus musculus protein" ; rdfs:subClassOf obo:PR_000036194 . obo:PR_000029067 obo:IAO_0000115 "A protein that is encoded in the genome of Homo sapiens." ; oboInOwl:hasExactSynonym "human protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000029067" ; a owl:Class ; rdfs:label "Homo sapiens protein" ; rdfs:subClassOf obo:PR_000036194 . obo:PR_000029968 obo:IAO_0000115 "A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide." ; oboInOwl:hasExactSynonym "fam:GH1" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000029968" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "somatotropin hormone family member" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000030035 obo:IAO_0000115 "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." ; oboInOwl:hasBroadSynonym "7TM receptor", "seven-transmembrane receptor" ; oboInOwl:hasDbXref "IUPHARfam:694" ; oboInOwl:hasExactSynonym "fam:GPCR" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000030035" ; a owl:Class ; rdfs:comment "Category=family. Classification based on GRAFS system. [PMID:12761335]" ; rdfs:label "G-protein coupled receptor" ; rdfs:subClassOf obo:PR_000000001, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004930 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004930 ] ) ] . obo:PR_000036194 obo:IAO_0000115 "A protein that is encoded in the genome of some Eukaryota." ; oboInOwl:hasExactSynonym "Eukaryota protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000036194" ; a owl:Class ; rdfs:label "eukaryotic protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000037069 obo:IAO_0000115 "A protein that includes at least one glycosylated residue." ; oboInOwl:hasExactSynonym "Prot/GlycoRes+", "glycated protein", "glycosylated protein" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000037069" ; a owl:Class ; rdfs:comment "Category=modification." ; rdfs:label "glycoprotein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000045358 obo:IAO_0000115 "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." ; oboInOwl:hasExactSynonym "fam:INS" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000045358" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "insulin family protein" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000049995 obo:IAO_0000115 "A protein that has alpha-amylase activity." ; oboInOwl:hasExactSynonym "fam:AMY" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000049995" ; a owl:Class ; rdfs:comment "Category=family. Note: The enzymatic activity corresponds to EC 3.2.1.1. This class refers only to functional enzymes; that is, those with measurable activity." ; rdfs:label "active alpha-amylase isozyme" ; rdfs:subClassOf obo:PR_000000001, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:PR_000000001 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0004556 ] ) ] ; vocab:crossSpeciesExactMatch obo:PR_000049996 . obo:PR_000049996 obo:IAO_0000115 "An active alpha-amylase isozyme that is encoded in the genome of human." ; oboInOwl:hasExactSynonym "fam:hAMY" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000049996" ; a owl:Class ; rdfs:comment "Category=organism-family. Requested by=HPO. Note: The enzymatic activity corresponds to EC 3.2.1.1. This class refers only to functional enzymes; that is, those with measurable activity. The isozymes are produced by the salivary glands (the identical AMY1A, AMY1B, and AMY1C genes) and the pancreas (AMY2A and AMY2B genes)." ; rdfs:label "active alpha-amylase isozyme (human)" ; rdfs:subClassOf obo:PR_000029067, obo:PR_000049995 . obo:PR_000050025 obo:IAO_0000115 "A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." ; oboInOwl:hasExactSynonym "fam:angiotensinogenase" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000050025" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "angiotensinogenase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050060 obo:IAO_0000115 "A protein that contains a single copy of the Glucose-6-phosphate dehydrogenase, NAD binding domain (Pfam:PF00479) at or near the N terminus, a single copy of the Glucose-6-phosphate dehydrogenase, C-terminal domain (Pfam:PF02781) at or near the C terminus, and no other domains." ; oboInOwl:hasExactSynonym "fam:G6PD" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000050060" ; a owl:Class ; rdfs:comment "Category=family." ; rdfs:label "glucose-6-phosphate dehydrogenase" ; rdfs:subClassOf obo:PR_000000001 . obo:PR_000050216 obo:IAO_0000115 "A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A)." ; oboInOwl:hasExactSynonym "CD45R", "PTPRC/iso:CD45R" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000050216" ; a owl:Class ; rdfs:comment "Category=seqgroup. Requested by=CL." ; rdfs:label "receptor-type tyrosine-protein phosphatase C isoform CD45R" ; rdfs:subClassOf obo:PR_000001006 . obo:PR_000050567 obo:IAO_0000115 "A material entity that minimally consists of a protein." ; oboInOwl:hasNarrowSynonym "protein", "protein aggregate", "protein complex", "protein-containing complex" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:id "PR:000050567" ; a owl:Class ; rdfs:comment "Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566)." ; rdfs:label "protein-containing material entity" ; rdfs:subClassOf obo:BFO_0000040, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000000001 ] ) ] . obo:PR_O14841 obo:IAO_0000115 "A 5-oxoprolinase that is encoded in the genome of human." ; oboInOwl:hasDbXref "Reactome:R-HSA-1247948", "UniProtKB:O14841" ; oboInOwl:hasExactSynonym "5-OPase (human)", "5-oxo-L-prolinase (human)", "hOPLAH", "pyroglutamase (human)" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "OPLAH" ; oboInOwl:id "PR:O14841" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "5-oxoprolinase (human)" ; rdfs:subClassOf obo:PR_000011649, obo:PR_000029067 . obo:PR_P00450 obo:IAO_0000115 "A ceruloplasmin that is encoded in the genome of human." ; oboInOwl:hasDbXref "UniProtKB:P00450" ; oboInOwl:hasExactSynonym "ferroxidase (human)", "hCP" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "CP" ; oboInOwl:id "PR:P00450" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "ceruloplasmin (human)" ; rdfs:subClassOf obo:PR_000005794, obo:PR_000029067 . obo:PR_P32754 obo:IAO_0000115 "A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human." ; oboInOwl:hasDbXref "UniProtKB:P32754" ; oboInOwl:hasExactSynonym "4-hydroxyphenylpyruvic acid oxidase (human)", "4HPPD (human)", "HPPDase (human)", "hHPD" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "HPD", "PPD" ; oboInOwl:id "PR:P32754" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "4-hydroxyphenylpyruvate dioxygenase (human)" ; rdfs:subClassOf obo:PR_000008730, obo:PR_000029067 . obo:PR_P47989 obo:IAO_0000115 "A xanthine dehydrogenase/oxidase that is encoded in the genome of human." ; oboInOwl:hasDbXref "UniProtKB:P47989" ; oboInOwl:hasExactSynonym "hXDH" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "XDH", "XDHA" ; oboInOwl:id "PR:P47989" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "xanthine dehydrogenase/oxidase (human)" ; rdfs:subClassOf obo:PR_000017477, obo:PR_000029067 . obo:PR_Q10469 obo:IAO_0000115 "An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human." ; oboInOwl:hasDbXref "Reactome:R-HSA-975830", "UniProtKB:Q10469" ; oboInOwl:hasExactSynonym "GNT-II (human)", "GlcNAc-T II (human)", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II (human)", "beta-1,2-N-acetylglucosaminyltransferase II (human)", "hMGAT2", "mannoside acetylglucosaminyltransferase 2 (human)" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "MGAT2" ; oboInOwl:id "PR:Q10469" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (human)" ; rdfs:subClassOf obo:PR_000010379, obo:PR_000029067 . obo:PR_Q12882 obo:IAO_0000115 "A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human." ; oboInOwl:hasDbXref "UniProtKB:Q12882" ; oboInOwl:hasExactSynonym "DHPDHase (human)", "DPD (human)", "dihydrothymine dehydrogenase (human)", "dihydrouracil dehydrogenase (human)", "hDPYD" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "DPYD" ; oboInOwl:id "PR:Q12882" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "dihydropyrimidine dehydrogenase [NADP(+)] (human)" ; rdfs:subClassOf obo:PR_000006678, obo:PR_000029067 . obo:PR_Q15848 obo:IAO_0000115 "An adiponectin that is encoded in the genome of human." ; oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasExactSynonym "30 kDa adipocyte complement-related protein (human)", "adipocyte complement-related 30 kDa protein (human)", "adipocyte, C1q and collagen domain-containing protein (human)", "adipose most abundant gene transcript 1 protein (human)", "apM-1 (human)", "gelatin-binding protein (human)", "hADIPOQ" ; oboInOwl:hasOBONamespace "protein" ; oboInOwl:hasRelatedSynonym "ACDC", "ACRP30", "ADIPOQ", "APM1", "GBP28" ; oboInOwl:id "PR:Q15848" ; a owl:Class ; rdfs:comment "Category=organism-gene." ; rdfs:label "adiponectin (human)" ; rdfs:subClassOf obo:PR_000003777, obo:PR_000029067 . obo:RO_0000052 obo:IAO_0000111 "inheres in"@en ; obo:IAO_0000112 "this fragility is a characteristic of this vase"@en, "this red color is a characteristic of this apple"@en ; obo:IAO_0000115 "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence."@en ; obo:IAO_0000118 "inheres_in"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0000052" ; oboInOwl:id "inheres_in" ; oboInOwl:shorthand "inheres_in" ; a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:comment "Note that this relation was previously called \"inheres in\", but was changed to be called \"characteristic of\" because BFO2 uses \"inheres in\" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing." ; rdfs:label "characteristic of"@en, "inheres in" ; rdfs:subPropertyOf obo:RO_0002314 ; owl:inverseOf obo:RO_0000053 . obo:RO_0000053 obo:IAO_0000111 "bearer of"@en ; obo:IAO_0000112 "this apple is bearer of this red color"@en, "this vase is bearer of this fragility"@en ; obo:IAO_0000115 "Inverse of characteristic_of"@en ; obo:IAO_0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist."@en ; obo:IAO_0000118 "bearer_of"@en, "is bearer of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:InverseFunctionalProperty, owl:ObjectProperty ; rdfs:label "has characteristic"@en ; rdfs:range obo:BFO_0000020 . obo:RO_0000056 obo:IAO_0000111 "participates in"@en ; obo:IAO_0000112 "this blood clot participates in this blood coagulation"@en, "this input material (or this output material) participates in this process"@en, "this investigator participates in this investigation"@en ; obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ; obo:IAO_0000118 "participates_in"@en ; oboInOwl:hasDbXref "RO:0000056" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "participates_in" ; oboInOwl:shorthand "participates_in" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "participates in", "participates in"@en ; rdfs:range obo:BFO_0000003 ; owl:inverseOf obo:RO_0000057 . obo:RO_0000057 obo:IAO_0000111 "has participant"@en ; obo:IAO_0000112 "this blood coagulation has participant this blood clot"@en, "this investigation has participant this investigator"@en, "this process has participant this input material (or this output material)"@en ; obo:IAO_0000115 "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ; obo:IAO_0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time."@en ; obo:IAO_0000118 "has_participant"@en ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "has participant"@en ; rdfs:range obo:BFO_0000002 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0000057 ) . obo:RO_0000079 obo:IAO_0000112 "this catalysis function is a function of this enzyme"@en ; obo:IAO_0000115 "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists."@en ; obo:IAO_0000118 "function_of"@en, "is function of"@en ; a owl:ObjectProperty ; rdfs:comment "This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020." ; rdfs:domain obo:BFO_0000034 ; rdfs:label "function of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000085 . obo:RO_0000080 obo:IAO_0000112 "this red color is a quality of this apple"@en ; obo:IAO_0000115 "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A quality inheres in its bearer at all times for which the quality exists."@en ; obo:IAO_0000118 "is quality of"@en, "quality_of"@en ; a owl:ObjectProperty ; rdfs:comment "This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020." ; rdfs:label "quality of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000086 . obo:RO_0000081 obo:IAO_0000112 "this investigator role is a role of this person"@en ; obo:IAO_0000115 "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists."@en ; obo:IAO_0000118 "is role of"@en, "role_of"@en ; a owl:ObjectProperty ; rdfs:comment "This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020." ; rdfs:label "role of"@en ; rdfs:subPropertyOf obo:RO_0000052 ; owl:inverseOf obo:RO_0000087 . obo:RO_0000085 obo:IAO_0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists."@en ; obo:IAO_0000118 "has_function"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has function"@en ; rdfs:range obo:BFO_0000034 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000086 obo:IAO_0000112 "this apple has quality this red color"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist."@en ; obo:IAO_0000118 "has_quality"@en ; oboInOwl:hasDbXref "RO:0000086" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_quality" ; oboInOwl:shorthand "has_quality" ; a owl:ObjectProperty ; rdfs:label "has quality", "has quality"@en ; rdfs:range obo:BFO_0000019 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000087 obo:IAO_0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)"@en ; obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ; obo:IAO_0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists."@en ; obo:IAO_0000118 "has_role"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has role"@en ; rdfs:range obo:BFO_0000023 ; rdfs:subPropertyOf obo:RO_0000053 . obo:RO_0000091 obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "has disposition"@en ; rdfs:range obo:BFO_0000016 ; rdfs:subPropertyOf obo:RO_0000053 ; owl:inverseOf obo:RO_0000092 . obo:RO_0000092 obo:IAO_0000115 "inverse of has disposition" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:comment "This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020." ; rdfs:label "disposition of"@en ; rdfs:subPropertyOf obo:RO_0000052 . obo:RO_0001015 obo:IAO_0000111 "is location of"@en ; obo:IAO_0000112 "my head is the location of my brain"@en, "this cage is the location of this rat"@en ; obo:IAO_0000115 "a relation between two independent continuants, the location and the target, in which the target is entirely within the location"@en ; obo:IAO_0000116 "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/"@en ; obo:IAO_0000118 "location_of"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0001015" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "location_of" ; oboInOwl:shorthand "location_of" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "location of", "location of"@en ; owl:inverseOf obo:RO_0001025 . obo:RO_0001018 obo:IAO_0000111 "contained in"@en ; obo:IAO_0000116 "Containment is location not involving parthood, and arises only where some immaterial continuant is involved.", "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):"@en, """Intended meaning: domain: material entity range: spatial region or site (immaterial continuant) """@en ; obo:IAO_0000118 "contained_in"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "contained in"@en ; rdfs:range obo:BFO_0000004 ; owl:inverseOf obo:RO_0001019 ; owl:propertyChainAxiom (obo:RO_0001025 obo:BFO_0000050 ) . obo:RO_0001019 obo:IAO_0000111 "contains"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0001019" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "contains" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "contains" ; a owl:ObjectProperty ; rdfs:label "contains", "contains"@en . obo:RO_0001025 obo:IAO_0000111 "located in"@en ; obo:IAO_0000112 "my brain is located in my head"@en, "this rat is located in this cage"@en ; obo:IAO_0000115 "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ; obo:IAO_0000116 "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus"@en, "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/"@en ; obo:IAO_0000118 "located_in"@en ; obo:RO_0001900 obo:RO_0001901 ; dc:source "http://www.obofoundry.org/ro/#OBO_REL:located_in" ; oboInOwl:hasDbXref "RO:0001025" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "located_in" ; oboInOwl:inSubset obo:valid_for_go_gp2term ; oboInOwl:shorthand "located_in" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000004, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000004 [ a owl:Class ; owl:complementOf obo:BFO_0000006 ] ) ] ; rdfs:label "located in", "located in"@en ; rdfs:range obo:BFO_0000004, [ a owl:Class ; owl:intersectionOf (obo:BFO_0000004 [ a owl:Class ; owl:complementOf obo:BFO_0000006 ] ) ] ; rdfs:seeAlso "https://wiki.geneontology.org/Located_in"^^xsd:anyURI ; owl:propertyChainAxiom (obo:RO_0001025 obo:BFO_0000050 ) . obo:RO_0001900 a owl:AnnotationProperty . obo:RO_0002000 obo:IAO_0000112 "the surface of my skin is a 2D boundary of my body"@en ; obo:IAO_0000115 "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity"@en ; obo:IAO_0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts."@en, "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape."@en ; obo:IAO_0000118 "2D_boundary_of"@en, "boundary of"@en, "is 2D boundary of"@en, "is boundary of"@en, "surface of"@en ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "2D boundary of"@en ; rdfs:subPropertyOf obo:RO_0002323 ; owl:inverseOf obo:RO_0002002 . obo:RO_0002002 obo:IAO_0000112 "my body has 2D boundary the surface of my skin"@en ; obo:IAO_0000115 "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity"@en ; obo:IAO_0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts."@en, "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape."@en ; obo:IAO_0000117 ; obo:IAO_0000118 "has boundary"@en, "has_2D_boundary"@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_boundary" ; oboInOwl:shorthand "has_boundary" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "has 2D boundary", "has 2D boundary"@en ; rdfs:range obo:BFO_0000141 ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002005 obo:IAO_0000117 ; cito:citesAsAuthority "http://www.ncbi.nlm.nih.gov/pubmed/22402613"^^xsd:anyURI ; oboInOwl:hasDbXref "RO:0002005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "innervated_by" ; oboInOwl:shorthand "innervated_by" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "innervated_by", "innervated_by"@en ; rdfs:range obo:UBERON_0000122 ; owl:inverseOf obo:RO_0002134 ; owl:propertyChainAxiom (obo:RO_0002005 obo:RO_0002380 ) . obo:RO_0002007 obo:IAO_0000115 """X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000""" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "bounding_layer_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "bounding_layer_of" ; a owl:ObjectProperty ; rdfs:comment "A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane." ; rdfs:domain [ a owl:Class ; owl:intersectionOf (obo:BFO_0000040 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0002124 ] ) ] ; rdfs:label "bounding layer of", "bounding layer of"@en ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002013 obo:IAO_0000115 "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-05-24T09:30:46Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "has regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002334 . obo:RO_0002014 obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-05-24T09:31:01Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'." ; rdfs:label "has negative regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002335 . obo:RO_0002015 obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-05-24T09:31:17Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'." ; rdfs:label "has positive regulatory component activity" ; rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002336 . obo:RO_0002017 oboInOwl:created_by ; oboInOwl:creation_date "2017-05-24T09:44:33Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ; rdfs:label "has component activity" ; rdfs:subPropertyOf obo:RO_0002018 . obo:RO_0002018 obo:IAO_0000115 "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-05-24T09:49:21Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has component process" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002180 . obo:RO_0002022 oboInOwl:created_by ; oboInOwl:creation_date "2017-09-17T13:52:24Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:comment "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ; rdfs:label "directly regulated by" ; rdfs:subPropertyOf obo:RO_0002334 ; owl:inverseOf obo:RO_0002578 . obo:RO_0002023 obo:IAO_0000115 "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-09-17T13:52:38Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "directly negatively regulated by" ; rdfs:subPropertyOf obo:RO_0002022 ; owl:inverseOf obo:RO_0002630 . obo:RO_0002024 obo:IAO_0000115 "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-09-17T13:52:47Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "directly positively regulated by" ; rdfs:subPropertyOf obo:RO_0002022 ; owl:inverseOf obo:RO_0002629 . obo:RO_0002025 obo:IAO_0000115 "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." ; oboInOwl:created_by ; oboInOwl:creation_date "2017-09-22T14:14:36Z"^^xsd:dateTime ; a owl:FunctionalProperty, owl:ObjectProperty ; rdfs:comment "This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations." ; rdfs:label "has effector activity" ; rdfs:subPropertyOf obo:RO_0002017 . obo:RO_0002081 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "<="@en ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "Primitive instance level timing relation between events" ; rdfs:label "before or simultaneous with"@en ; rdfs:subPropertyOf obo:RO_0002222 . obo:RO_0002082 obo:IAO_0000115 "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." ; obo:IAO_0000117 , "David Osumi-Sutherland" ; oboInOwl:hasDbXref "RO:0002082" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "simultaneous_with" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "simultaneous_with" ; a owl:ObjectProperty, owl:SymmetricProperty, owl:TransitiveProperty ; rdfs:comment "t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)"@en ; rdfs:label "simultaneous with", "simultaneous with"@en ; rdfs:subPropertyOf obo:RO_0002081 . obo:RO_0002086 obo:IAO_0000117 "David Osumi-Sutherland" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)"@en ; rdfs:label "ends after"@en ; rdfs:subPropertyOf obo:RO_0002222 . obo:RO_0002087 obo:IAO_0000117 "David Osumi-Sutherland" ; obo:IAO_0000118 "starts_at_end_of" ; oboInOwl:hasDbXref "RO:0002087" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "immediately_preceded_by" ; oboInOwl:shorthand "immediately_preceded_by" ; a owl:ObjectProperty ; rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"@en ; rdfs:label "immediately preceded by", "immediately preceded by"@en ; rdfs:subPropertyOf obo:BFO_0000062 ; owl:inverseOf obo:RO_0002090 ; owl:propertyChainAxiom (obo:RO_0002224 obo:RO_0002230 ) . obo:RO_0002090 obo:IAO_0000117 , "David Osumi-Sutherland" ; obo:IAO_0000118 "ends_at_start_of", "meets" ; obo:RO_0002575 obo:BFO_0000063 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ; rdfs:label "immediately precedes"@en ; rdfs:subPropertyOf obo:BFO_0000063 ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002224 ) . obo:RO_0002100 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between a neuron and a material anatomical entity that its soma is part of."@en ; obo:IAO_0000117 ; obo:IAO_0000424 """ some ( and some ?Y)""" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000540 ; rdfs:label "has soma location"@en ; rdfs:range obo:UBERON_0000465 ; rdfs:subPropertyOf obo:RO_0002131 ; owl:propertyChainAxiom (obo:RO_0002100 obo:BFO_0000050 ) . obo:RO_0002103 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "@en ; obo:IAO_0000117 , ; obo:IAO_0000424 " some ( that part_of some ( that has_part some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; oboInOwl:hasDbXref "RO:0002103" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "synapsed_by" ; oboInOwl:shorthand "synapsed_by" ; a owl:ObjectProperty ; rdfs:label "synapsed by", "synapsed by"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ; rdfs:subPropertyOf obo:RO_0002485 ; owl:inverseOf obo:RO_0002120 . obo:RO_0002104 obo:IAO_0000112 "Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]"@en ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ; obo:IAO_0000117 , , ; obo:IAO_0000119 ; obo:IAO_0000424 " some ( and some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000465 ; rdfs:label "has plasma membrane part"@en ; rdfs:range obo:UBERON_0000465 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002120 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """ Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to. """@en ; obo:IAO_0000117 , ; obo:IAO_0000424 " some ( that part_of some ( that some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; a owl:ObjectProperty ; rdfs:comment """N1 synapsed_to some N2 Expands to: N1 SubclassOf ( has_part some ( ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( ‘synapse ; GO:0045202’ that has_part some ( ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))""" ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:CL_0000540 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:CL_0000540 ] ) ] ; rdfs:label "synapsed to"@en ; rdfs:subPropertyOf obo:RO_0002486 . obo:RO_0002131 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x overlaps y if and only if there exists some z such that x has part z and z part of y" ; obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002131" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "overlaps" ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; oboInOwl:shorthand "overlaps" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "overlaps", "overlaps"@en ; rdfs:subPropertyOf obo:RO_0002323 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:BFO_0000050 ), (obo:BFO_0000051 obo:BFO_0000050 ), (obo:BFO_0000051 obo:RO_0002131 ), (obo:RO_0002131 obo:BFO_0000050 ) . obo:RO_0002134 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 """Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R."""@en ; obo:IAO_0000117 ; obo:IAO_0000424 " some ( that ( some ( that some Y?)))" ; obo:RO_0001900 obo:RO_0001901 ; cito:citesAsAuthority ; oboInOwl:hasDbXref "RO:0002134" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "innervates" ; oboInOwl:shorthand "innervates" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000122 ; rdfs:label "innervates", "innervates"@en ; owl:propertyChainAxiom (obo:RO_0002134 obo:BFO_0000050 ) . obo:RO_0002150 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "X continuous_with Y if and only if X and Y share a fiat boundary." ; obo:IAO_0000117 ; obo:IAO_0000118 "connected to" ; obo:IAO_0000232 "The label for this relation was previously connected to. I relabeled this to \"continuous with\". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint)" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002150" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "continuous_with" ; oboInOwl:shorthand "continuous_with" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "continuous with", "continuous with"@en ; rdfs:range obo:BFO_0000004 ; rdfs:seeAlso "FMA:85972" ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002156 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." ; obo:IAO_0000118 "ancestral_stucture_of", "evolutionarily_descended_from" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "derived by descent from" ; rdfs:subPropertyOf obo:RO_0002320 ; owl:inverseOf obo:RO_0002157 . obo:RO_0002157 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of derived by descent from" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has derived by descendant" ; rdfs:subPropertyOf obo:RO_0002320 . obo:RO_0002158 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." ; obo:IAO_0000232 "Consider obsoleting and merging with child relation, 'in homology relationship with'" ; oboInOwl:hasDbXref "RO:0002158" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "homologous_to" ; oboInOwl:shorthand "homologous_to" ; a owl:ObjectProperty, owl:SymmetricProperty, owl:TransitiveProperty ; rdfs:comment "VBO calls this homologous_to" ; rdfs:label "shares ancestor with" ; rdfs:subPropertyOf obo:RO_0002320 ; owl:propertyChainAxiom (obo:RO_0002156 obo:RO_0002157 ) . obo:RO_0002159 obo:IAO_0000114 obo:IAO_0000125 ; oboInOwl:hasDbXref "RO:0002159" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "serially_homologous_to" ; oboInOwl:shorthand "serially_homologous_to" ; a owl:ObjectProperty, owl:SymmetricProperty, owl:TransitiveProperty ; rdfs:label "serially homologous to" ; rdfs:subPropertyOf obo:RO_0002320 . obo:RO_0002161 a owl:AnnotationProperty . obo:RO_0002163 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "A is spatially_disjoint_from B if and only if they have no parts in common" ; obo:IAO_0000116 "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. "@en ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000232 "Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy" ; obo:IAO_0000424 "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:label "spatially disjoint from" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002170 obo:IAO_0000112 "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ; obo:IAO_0000115 "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002170" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "connected_to" ; oboInOwl:shorthand "connected_to" ; a owl:ObjectProperty ; rdfs:domain [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:label "connected to", "connected to"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI, "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 ; owl:propertyChainAxiom ([ owl:inverseOf obo:RO_0002176 ] obo:RO_0002176 ) . obo:RO_0002171 a owl:AnnotationProperty . obo:RO_0002174 a owl:AnnotationProperty . obo:RO_0002175 a owl:AnnotationProperty . obo:RO_0002176 obo:IAO_0000112 "The M8 connects Glasgow and Edinburgh", "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ; obo:IAO_0000115 "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002176" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "connects" ; oboInOwl:shorthand "connects" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "connects", "connects"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:RO_0002577 ] ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI, "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002177 obo:IAO_0000115 "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." ; obo:IAO_0000589 "attached to part of (anatomical structure to anatomical structure)" ; oboInOwl:hasDbXref "RO:0002177" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "attaches_to_part_of" ; oboInOwl:shorthand "attaches_to_part_of" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "attached to part of", "attached to part of"@en ; rdfs:range obo:UBERON_0000061 ; rdfs:subPropertyOf obo:RO_0002323, obo:RO_0002567 ; owl:propertyChainAxiom (obo:RO_0002371 obo:BFO_0000050 ) . obo:RO_0002178 obo:IAO_0000115 "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." ; obo:IAO_0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure" ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002178" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "supplies" ; oboInOwl:shorthand "supplies" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0001637 ; rdfs:label "supplies", "supplies"@en ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002179 obo:IAO_0000115 "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." ; obo:IAO_0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure" ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002179" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "drains" ; oboInOwl:shorthand "drains" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0001638 ; rdfs:label "drains", "drains"@en ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002180 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ; obo:IAO_0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." ; obo:IAO_0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit."@en ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002180" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_component" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "has_component" ; a owl:ObjectProperty ; rdfs:label "has component", "has component"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002202 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" ; obo:IAO_0000117 , , , ; oboInOwl:hasDbXref "RO:0002202" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "develops_from" ; oboInOwl:shorthand "develops_from" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:comment "This is the transitive form of the develops from relation" ; rdfs:domain obo:BFO_0000004 ; rdfs:label "develops from", "develops from"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002254, obo:RO_0002258 ; owl:inverseOf obo:RO_0002203 . obo:RO_0002203 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of develops from" ; obo:IAO_0000117 , , ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "develops into"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002387, obo:RO_0002388 . obo:RO_0002206 obo:IAO_0000112 "'neural crest cell' SubClassOf expresses some 'Wnt1 gene'" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002, [ a owl:Class ; owl:unionOf (obo:BFO_0000031 obo:BFO_0000040 ) ] ; rdfs:label "expressed in"@en ; rdfs:range obo:UBERON_0000465 ; rdfs:subPropertyOf obo:RO_0002330 ; owl:inverseOf obo:RO_0002292 ; owl:propertyChainAxiom (obo:RO_0002206 obo:BFO_0000050 ) . obo:RO_0002207 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." ; obo:IAO_0000117 , ; obo:IAO_0000119 "FBbt" ; obo:RO_0002575 obo:RO_0002202 ; oboInOwl:hasDbXref "RO:0002207" ; oboInOwl:hasExactSynonym "has developmental precursor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "directly_develops_from" ; oboInOwl:shorthand "directly_develops_from" ; a owl:ObjectProperty ; rdfs:comment "TODO - add child relations from DOS" ; rdfs:domain [ a owl:Class ; owl:unionOf (obo:CL_0000000 obo:UBERON_0010000 ) ] ; rdfs:label "directly develops from", "directly develops from"@en ; rdfs:range [ a owl:Class ; owl:unionOf (obo:CL_0000000 obo:UBERON_0010000 ) ] ; rdfs:subPropertyOf obo:RO_0002202 ; owl:inverseOf obo:RO_0002210 . obo:RO_0002210 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of directly develops from" ; obo:IAO_0000118 "developmental precursor of" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "directly develops into"@en ; rdfs:subPropertyOf obo:RO_0002203 . obo:RO_0002211 obo:IAO_0000115 "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." ; obo:IAO_0000117 , , ; obo:IAO_0000119 , "GO" ; obo:IAO_0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." ; obo:IAO_0000589 "regulates (processual)" ; obo:IAO_0000600 false ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulates"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002411 ; owl:inverseOf obo:RO_0002334 ; owl:propertyChainAxiom (obo:RO_0002211 obo:RO_0002025 ), (obo:RO_0002230 obo:RO_0002211 ), (obo:RO_0002578 obo:RO_0002578 ) . obo:RO_0002212 obo:IAO_0000115 "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000589 "negatively regulates (process to process)" ; obo:RO_0004050 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "negatively regulates"@en ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002305 ; owl:inverseOf obo:RO_0002335 ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002212 ) . obo:RO_0002213 obo:IAO_0000115 "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000589 "positively regulates (process to process)" ; obo:RO_0004049 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "positively regulates"@en ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002304 ; owl:inverseOf obo:RO_0002336 ; owl:propertyChainAxiom (obo:RO_0002212 obo:RO_0002212 ), (obo:RO_0002230 obo:RO_0002213 ) . obo:RO_0002215 obo:IAO_0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)", "osteoclast SubClassOf 'capable of' some 'bone resorption'" ; obo:IAO_0000115 "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ; obo:IAO_0000117 ; obo:IAO_0000118 "has function realized in" ; obo:IAO_0000119 , ; obo:IAO_0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." ; oboInOwl:hasDbXref "RO:0002215" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "capable_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "capable_of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "capable of", "capable of"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002216 . obo:RO_0002216 obo:IAO_0000115 "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ; obo:IAO_0000117 ; obo:IAO_0000118 "has function in" ; oboInOwl:hasDbXref "RO:0002216" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "capable_of_part_of" ; oboInOwl:shorthand "capable_of_part_of" ; a owl:ObjectProperty ; rdfs:label "capable of part of", "capable of part of"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002215 obo:BFO_0000050 ) . obo:RO_0002219 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" ; obo:IAO_0000117 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002219" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "surrounded_by" ; oboInOwl:shorthand "surrounded_by" ; a owl:ObjectProperty ; rdfs:label "surrounded by", "surrounded by"@en ; rdfs:subPropertyOf obo:RO_0002220 ; owl:inverseOf obo:RO_0002221 . obo:RO_0002220 obo:IAO_0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.", "The epidermis layer of a vertebrate is adjacent to the dermis.", "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.", "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x adjacent to y if and only if x and y share a boundary." ; obo:IAO_0000116 "This relation acts as a join point with BSPO" ; obo:IAO_0000117 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002220" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "adjacent_to" ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; oboInOwl:shorthand "adjacent_to" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "adjacent to", "adjacent to"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002163 . obo:RO_0002221 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of surrounded by" ; obo:IAO_0000117 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002221" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "surrounds" ; oboInOwl:inSubset obo:RO_0002259 ; oboInOwl:shorthand "surrounds" ; a owl:ObjectProperty ; rdfs:label "surrounds", "surrounds"@en ; rdfs:subPropertyOf obo:RO_0002220 . obo:RO_0002222 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." ; dcterms:source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1"^^xsd:anyURI ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ; rdfs:domain obo:BFO_0000003 ; rdfs:label "temporally related to"@en ; rdfs:range obo:BFO_0000003 . obo:RO_0002223 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of starts with" ; obo:IAO_0000117 , "Chris Mungall" ; obo:IAO_0000119 "Allen" ; oboInOwl:hasDbXref "RO:0002223" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "starts" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "starts" ; a owl:ObjectProperty ; rdfs:label "starts", "starts"@en ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002222 ; owl:inverseOf obo:RO_0002224 . obo:RO_0002224 obo:IAO_0000112 "Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ; obo:IAO_0000117 , "Chris Mungall" ; obo:IAO_0000118 "started by" ; oboInOwl:hasDbXref "RO:0002224" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "starts_with" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "starts_with" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "starts with", "starts with"@en ; rdfs:subPropertyOf obo:BFO_0000051, obo:RO_0002222 . obo:RO_0002225 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002225" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "develops_from_part_of" ; oboInOwl:shorthand "develops_from_part_of" ; a owl:ObjectProperty ; rdfs:label "develops from part of", "develops from part of"@en ; rdfs:subPropertyOf obo:RO_0002202 ; owl:propertyChainAxiom (obo:RO_0002207 obo:BFO_0000050 ) . obo:RO_0002226 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x develops_in y if x is located in y whilst x is developing" ; obo:IAO_0000117 ; obo:IAO_0000119 "EHDAA2", "Jonathan Bard, EHDAA2" ; oboInOwl:hasDbXref "RO:0002226" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "develops_in" ; oboInOwl:shorthand "develops_in" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0001062 ; rdfs:label "develops in", "develops in"@en ; rdfs:subPropertyOf obo:RO_0002258 ; owl:propertyChainAxiom (obo:RO_0002207 obo:RO_0001025 ) . obo:RO_0002229 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of ends with" ; obo:IAO_0000117 , "Chris Mungall" ; oboInOwl:hasDbXref "RO:0002229" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "ends" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "ends" ; a owl:ObjectProperty ; rdfs:label "ends", "ends"@en ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002222 ; owl:inverseOf obo:RO_0002230 . obo:RO_0002230 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ; obo:IAO_0000117 , "Chris Mungall" ; obo:IAO_0000118 "finished by" ; oboInOwl:hasDbXref "RO:0002230" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "ends_with" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "ends_with" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "ends with", "ends with"@en ; rdfs:subPropertyOf obo:BFO_0000051, obo:RO_0002222 . obo:RO_0002231 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" ; obo:IAO_0000117 ; obo:IAO_0000118 "starts with process that occurs in" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has start location"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002479 ; owl:propertyChainAxiom (obo:RO_0002224 obo:BFO_0000066 ) . obo:RO_0002232 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" ; obo:IAO_0000117 ; obo:IAO_0000118 "ends with process that occurs in" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has end location"@en ; rdfs:range obo:BFO_0000004 ; rdfs:subPropertyOf obo:RO_0002479 ; owl:propertyChainAxiom (obo:RO_0002230 obo:BFO_0000066 ) . obo:RO_0002233 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ; obo:IAO_0000117 ; obo:IAO_0000118 "consumes" ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "has input"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Has_input"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0000057 ; owl:inverseOf obo:RO_0002352 ; owl:propertyChainAxiom (obo:RO_0002224 obo:RO_0002233 ) . obo:RO_0002234 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." ; obo:IAO_0000117 ; obo:IAO_0000118 "produces" ; oboInOwl:inSubset subsets:ro-eco, obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "has output"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Has_output"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0000057 ; owl:inverseOf obo:RO_0002353 ; owl:propertyChainAxiom (obo:RO_0002230 obo:RO_0002234 ) . obo:RO_0002254 obo:IAO_0000112 "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x has developmental contribution from y iff x has some part z such that z develops from y"@en ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002254" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_developmental_contribution_from" ; oboInOwl:shorthand "has_developmental_contribution_from" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0001062 ; rdfs:label "has developmental contribution from", "has developmental contribution from"@en ; rdfs:range obo:UBERON_0001062 ; rdfs:subPropertyOf obo:RO_0002258 ; owl:inverseOf obo:RO_0002255 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0002202 ) . obo:RO_0002255 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "inverse of has developmental contribution from" ; obo:IAO_0000117 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "developmentally contributes to"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002385 ; owl:propertyChainAxiom (obo:RO_0002203 obo:BFO_0000050 ) . obo:RO_0002256 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T" ; obo:IAO_0000117 , , ; obo:IAO_0000118 "induced by" ; obo:IAO_0000119 , " Developmental Biology, Gilbert, 8th edition, figure 6.5(F)", "GO:0001759" ; obo:IAO_0000232 "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" ; oboInOwl:hasDbXref "RO:0002256" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "developmentally_induced_by" ; oboInOwl:shorthand "developmentally_induced_by" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000465 ; rdfs:label "developmentally induced by", "developmentally induced by"@en ; rdfs:range obo:UBERON_0000465 ; rdfs:subPropertyOf obo:RO_0002258 ; owl:inverseOf obo:RO_0002257 . obo:RO_0002257 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Inverse of developmentally induced by"@en ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "developmentally induces"@en ; rdfs:subPropertyOf obo:RO_0002286, obo:RO_0002386 . obo:RO_0002258 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" ; obo:IAO_0000116 false ; obo:IAO_0000117 ; obo:IAO_0000232 "In general you should not use this relation to make assertions - use one of the more specific relations below this one" ; a owl:ObjectProperty ; rdfs:comment "This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from" ; rdfs:domain obo:BFO_0000002 ; rdfs:label "developmentally preceded by"@en ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002324 ; owl:inverseOf obo:RO_0002286 . obo:RO_0002259 a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:RO_0002263 obo:IAO_0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." ; obo:IAO_0000115 "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002411 ) . obo:RO_0002264 obo:IAO_0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." ; obo:IAO_0000115 "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ; oboInOwl:hasRelatedSynonym "affects" ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within" ; rdfs:seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002418 ) . obo:RO_0002285 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" ; obo:IAO_0000116 "This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage" ; obo:IAO_0000117 ; obo:IAO_0000118 "replaces" ; oboInOwl:hasDbXref "RO:0002285" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "developmentally_replaces" ; oboInOwl:shorthand "developmentally_replaces" ; a owl:ObjectProperty ; rdfs:label "developmentally replaces", "developmentally replaces"@en ; rdfs:subPropertyOf obo:RO_0002258 . obo:RO_0002286 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "Inverse of developmentally preceded by" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "developmentally succeeded by"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002287 obo:IAO_0000112 "'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue" ; obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "part of developmental precursor of"@en ; rdfs:subPropertyOf obo:RO_0002286 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002210 ) . obo:RO_0002292 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "expresses"@en ; rdfs:subPropertyOf obo:RO_0002330 . obo:RO_0002304 obo:IAO_0000115 "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." ; obo:RO_0004049 obo:RO_0002411 ; dcterms:creator ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:comment "holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y" ; rdfs:label "causally upstream of, positive effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004047 . obo:RO_0002305 obo:IAO_0000115 "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." ; obo:RO_0004050 obo:RO_0002411 ; dcterms:creator ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "causally upstream of, negative effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004046 . obo:RO_0002314 obo:IAO_0000115 "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." ; obo:IAO_0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" ; obo:IAO_0000117 ; obo:IAO_0000118 "inheres in part of" ; obo:IAO_0000119 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002314" ; oboInOwl:id "inheres_in_part_of" ; oboInOwl:shorthand "inheres_in_part_of" ; a owl:ObjectProperty ; rdfs:label "characteristic of part of"@en, "inheres in part of" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002502 ; owl:propertyChainAxiom (obo:RO_0000052 obo:BFO_0000050 ), (obo:RO_0000052 obo:BFO_0000050 ), (obo:RO_0002314 obo:BFO_0000050 ) . obo:RO_0002320 obo:IAO_0000115 "A relationship that holds via some environmental process" ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." ; a owl:ObjectProperty ; rdfs:label "evolutionarily related to"@en . obo:RO_0002323 obo:IAO_0000115 "A mereological relationship or a topological relationship" ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "mereotopologically related to"@en . obo:RO_0002324 obo:IAO_0000115 "A relationship that holds between entities participating in some developmental process (GO:0032502)" ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" ; a owl:ObjectProperty ; rdfs:label "developmentally related to"@en . obo:RO_0002327 obo:IAO_0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" ; obo:IAO_0000115 "c enables p iff c is capable of p and c acts to execute p." ; obo:IAO_0000117 ; obo:IAO_0000118 "catalyzes", "executes", "has", "is catalyzing", "is executing" ; obo:IAO_0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "enables"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Enables"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002215 ; owl:inverseOf obo:RO_0002333 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000051 ), (obo:RO_0002327 obo:RO_0002017 ) . obo:RO_0002328 obo:IAO_0000115 "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ; obo:IAO_0000117 ; obo:IAO_0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" ; oboInOwl:hasDbXref "RO:0002328" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "functionally_related_to" ; oboInOwl:shorthand "functionally_related_to" ; a owl:ObjectProperty ; rdfs:label "functionally related to", "functionally related to"@en . obo:RO_0002329 obo:IAO_0000115 "this relation holds between c and p when c is part of some c', and c' is capable of p." ; obo:IAO_0000117 ; obo:IAO_0000118 false ; a owl:ObjectProperty ; rdfs:label "part of structure that is capable of"@en ; rdfs:subPropertyOf obo:RO_0002328 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002215 ) . obo:RO_0002330 obo:IAO_0000115 "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "genomically related to"@en ; rdfs:range obo:BFO_0000002 . obo:RO_0002331 obo:IAO_0000115 "c involved_in p if and only if c enables some process p', and p' is part of p" ; obo:IAO_0000117 ; obo:IAO_0000118 "actively involved in", "enables part of" ; a owl:ObjectProperty ; rdfs:label "involved in"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Involved_in"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002431 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000050 ), (obo:RO_0002331 obo:BFO_0000050 ) . obo:RO_0002333 obo:IAO_0000115 "inverse of enables" ; obo:IAO_0000117 ; oboInOwl:inSubset obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "enabled by"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Enabled_by"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0000057, obo:RO_0002328 . obo:RO_0002334 obo:IAO_0000115 "inverse of regulates" ; obo:IAO_0000117 ; obo:IAO_0000589 "regulated by (processual)" ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulated by"@en ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002427 . obo:RO_0002335 obo:IAO_0000115 "inverse of negatively regulates" ; obo:IAO_0000117 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "negatively regulated by"@en ; rdfs:subPropertyOf obo:RO_0002334 . obo:RO_0002336 obo:IAO_0000115 "inverse of positively regulates" ; obo:IAO_0000117 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty ; rdfs:label "positively regulated by"@en ; rdfs:subPropertyOf obo:RO_0002334 . obo:RO_0002337 obo:IAO_0000115 "A relationship that holds via some process of localization" ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is a grouping relation." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "related via localization to"@en ; rdfs:range obo:BFO_0000002 . obo:RO_0002339 obo:IAO_0000115 "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." ; obo:IAO_0000117 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "has target end location"@en ; rdfs:subPropertyOf obo:RO_0002344 ; owl:propertyChainAxiom (obo:RO_0002339 obo:BFO_0000050 ) . obo:RO_0002344 obo:IAO_0000112 "'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739)" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "results in transport to from or in"@en ; rdfs:subPropertyOf obo:RO_0002337 . obo:RO_0002350 obo:IAO_0000112 "An organism that is a member of a population of organisms" ; obo:IAO_0000115 "is member of is a mereological relation between a item and a collection." ; obo:IAO_0000118 "is member of", "member part of" ; obo:IAO_0000119 "SIO" ; obo:RO_0001900 obo:RO_0001901 ; a owl:ObjectProperty ; rdfs:label "member of"@en ; rdfs:subPropertyOf obo:BFO_0000050 ; owl:inverseOf obo:RO_0002351 . obo:RO_0002351 obo:IAO_0000115 "has member is a mereological relation between a collection and an item." ; obo:IAO_0000119 "SIO" ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002351" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_member" ; oboInOwl:shorthand "has_member" ; a owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:label "has member", "has member"@en ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002352 obo:IAO_0000115 "inverse of has input" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002352" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "input_of" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; oboInOwl:shorthand "input_of" ; a owl:ObjectProperty ; rdfs:label "input of", "input of"@en ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002328 . obo:RO_0002353 obo:IAO_0000115 "inverse of has output" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002353" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "output_of" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; oboInOwl:shorthand "output_of" ; a owl:ObjectProperty ; rdfs:label "output of", "output of"@en ; rdfs:subPropertyOf obo:RO_0000056, obo:RO_0002328 . obo:RO_0002371 obo:IAO_0000115 "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" ; obo:IAO_0000117 ; obo:IAO_0000589 "attached to (anatomical structure to anatomical structure)" ; oboInOwl:hasDbXref "RO:0002371" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "attaches_to" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "attaches_to" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "attached to", "attached to"@en ; rdfs:subPropertyOf obo:RO_0002170, obo:RO_0002177 . obo:RO_0002372 obo:IAO_0000115 "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to."@en ; obo:IAO_0000117 ; obo:IAO_0000119 "Wikipedia:Insertion_(anatomy)"@en ; oboInOwl:hasDbXref "RO:0002372" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_muscle_origin" ; oboInOwl:shorthand "has_muscle_origin" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "has muscle origin", "has muscle origin"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002371, obo:RO_0002567 . obo:RO_0002373 obo:IAO_0000115 "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone."@en ; obo:IAO_0000117 ; obo:IAO_0000119 "Wikipedia:Insertion_(anatomy)"@en ; oboInOwl:hasDbXref "RO:0002373" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_muscle_insertion" ; oboInOwl:shorthand "has_muscle_insertion" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "has muscle insertion", "has muscle insertion"@en ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002371, obo:RO_0002567 . obo:RO_0002374 obo:IAO_0000112 false ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat"@en ; obo:IAO_0000117 ; obo:IAO_0000119 ; oboInOwl:hasBroadSynonym "has fused element" ; oboInOwl:hasDbXref "RO:0002374" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_fused_element" ; oboInOwl:shorthand "has_fused_element" ; a owl:ObjectProperty ; rdfs:comment "A has_fused_element B does not imply that A has_part some B: rather than A has_part some B', where B' that has some evolutionary relationship to B."@en ; rdfs:label "derived from ancestral fusion of", "derived from ancestral fusion of"@en ; rdfs:subPropertyOf obo:RO_0002156 . obo:RO_0002375 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships", "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)" ; obo:RO_0004036 obo:BFO_0000050 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "in branching relationship with"@en ; rdfs:range obo:BFO_0000040 ; rdfs:seeAlso , "https://github.com/obophenotype/uberon/issues/170"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002323 . obo:RO_0002376 obo:IAO_0000112 "Deschutes River tributary_of Columbia River", "inferior epigastric vein tributary_of external iliac vein" ; obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." ; obo:IAO_0000117 ; obo:IAO_0000118 "drains into", "drains to", "tributary channel of" ; obo:IAO_0000119 "http://en.wikipedia.org/wiki/Tributary", "http://www.medindia.net/glossary/venous_tributary.htm" ; obo:IAO_0000232 "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries)"^^xsd:anyURI ; oboInOwl:hasDbXref "RO:0002376" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "tributary_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "tributary_of" ; a owl:ObjectProperty ; rdfs:label "tributary of", "tributary of"@en ; rdfs:seeAlso , "http://en.wikipedia.org/wiki/Tributary"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002170, obo:RO_0002375 . obo:RO_0002379 obo:IAO_0000112 "A lump of clay and a statue" ; obo:IAO_0000115 "x spatially_coextensive_with y if and inly if x and y have the same location" ; obo:IAO_0000117 ; obo:IAO_0000232 "This relation is added for formal completeness. It is unlikely to be used in many practical scenarios" ; a owl:ObjectProperty ; rdfs:label "spatially coextensive with"@en ; rdfs:subPropertyOf obo:RO_0002131 ; owl:propertyChainAxiom (obo:RO_0001025 [ owl:inverseOf obo:RO_0001025 ] ) . obo:RO_0002380 obo:IAO_0000112 "In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is a (direct) branching part of T. B1-1, B1-2, and B1-3 are also branching parts of T, but these are considered indirect branching parts as they do not directly connect to the main stem S" ; obo:IAO_0000115 "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002380" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "branching_part_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "branching_part_of" ; a owl:ObjectProperty ; rdfs:label "branching part of", "branching part of"@en ; rdfs:range [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0000402 ] ; rdfs:seeAlso , "FMA:85994" ; rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002375 ; owl:inverseOf obo:RO_0002569 . obo:RO_0002384 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)."@en ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0001062 ; rdfs:label "has developmental potential involving"@en ; rdfs:range obo:UBERON_0001062 ; rdfs:subPropertyOf obo:RO_0002324 . obo:RO_0002385 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y"@en ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002385" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_potential_to_developmentally_contribute_to" ; oboInOwl:shorthand "has_potential_to_developmentally_contribute_to" ; a owl:ObjectProperty ; rdfs:label "has potential to developmentally contribute to", "has potential to developmentally contribute to"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002386 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y"@en ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "has potential to developmentally induce"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002387 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has the potential to develop into y iff x develops into y or if x is capable of developing into y"@en ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002387" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_potential_to_develop_into" ; oboInOwl:shorthand "has_potential_to_develop_into" ; a owl:ObjectProperty ; rdfs:label "has potential to develop into", "has potential to develop into"@en ; rdfs:subPropertyOf obo:RO_0002384 . obo:RO_0002388 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y"@en ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "has potential to directly develop into"@en ; rdfs:subPropertyOf obo:RO_0002387 . obo:RO_0002404 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000115 "inverse of upstream of" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "causally downstream of"@en ; rdfs:subPropertyOf obo:BFO_0000062, obo:RO_0002427 ; owl:inverseOf obo:RO_0002411 . obo:RO_0002405 obo:IAO_0000114 obo:IAO_0000428 ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "immediately causally downstream of"@en ; rdfs:subPropertyOf obo:RO_0002087, obo:RO_0002404 ; owl:inverseOf obo:RO_0002412 . obo:RO_0002407 obo:IAO_0000115 "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." ; obo:IAO_0000117 ; obo:IAO_0000118 "indirectly activates" ; obo:RO_0002579 obo:RO_0002213 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "indirectly positively regulates"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002213, obo:RO_0012012 ; owl:propertyChainAxiom (obo:RO_0002407 obo:RO_0002629 ), (obo:RO_0002409 obo:RO_0002409 ), (obo:RO_0002629 obo:RO_0002407 ), (obo:RO_0002629 obo:RO_0002629 ) . obo:RO_0002409 obo:IAO_0000115 "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." ; obo:IAO_0000117 ; obo:IAO_0000118 "indirectly inhibits" ; obo:RO_0002579 obo:RO_0002212 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "indirectly negatively regulates"@en ; rdfs:seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002212, obo:RO_0012012 ; owl:propertyChainAxiom (obo:RO_0002409 obo:RO_0002630 ), (obo:RO_0002630 obo:RO_0002409 ), (obo:RO_0002630 obo:RO_0002630 ) . obo:RO_0002410 obo:IAO_0000115 "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." ; obo:IAO_0000116 """This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative? The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types.""" ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:label "causally related to"@en . obo:RO_0002411 obo:IAO_0000115 "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." ; obo:IAO_0000117 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_gocam ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally upstream of"@en ; rdfs:subPropertyOf obo:BFO_0000063, obo:RO_0002418 . obo:RO_0002412 obo:IAO_0000115 "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." ; obo:IAO_0000117 ; obo:RO_0002575 obo:RO_0002411 ; a owl:ObjectProperty ; rdfs:label "immediately causally upstream of"@en ; rdfs:subPropertyOf obo:RO_0002090, obo:RO_0002411 . obo:RO_0002418 obo:IAO_0000115 "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." ; obo:IAO_0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" ; obo:IAO_0000117 ; obo:IAO_0000118 "influences (processual)" ; oboInOwl:hasRelatedSynonym "affects" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally upstream of or within" ; rdfs:subPropertyOf obo:RO_0002501 ; owl:inverseOf obo:RO_0002427 . obo:RO_0002427 obo:IAO_0000115 "inverse of causally upstream of or within" ; obo:IAO_0000117 ; obo:IAO_0000119 ; oboInOwl:inSubset obo:RO_0002259 ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "causally downstream of or within" ; rdfs:subPropertyOf obo:RO_0002501 . obo:RO_0002428 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' regulates some p" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "involved in regulation of" ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0002431 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002211 ), (obo:RO_0002331 obo:RO_0002211 ) . obo:RO_0002429 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ; obo:IAO_0000117 ; obo:RO_0004049 obo:RO_0002428 ; a owl:ObjectProperty ; rdfs:label "involved in positive regulation of" ; rdfs:subPropertyOf obo:RO_0002428 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002213 ), (obo:RO_0002331 obo:RO_0002213 ) . obo:RO_0002430 obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ; obo:IAO_0000117 ; obo:RO_0004050 obo:RO_0002428 ; a owl:ObjectProperty ; rdfs:label "involved in negative regulation of" ; rdfs:subPropertyOf obo:RO_0002428 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002212 ), (obo:RO_0002331 obo:RO_0002212 ) . obo:RO_0002431 obo:IAO_0000115 "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ; obo:IAO_0000116 "OWL does not allow defining object properties via a Union" ; obo:IAO_0000117 ; obo:IAO_0000118 "involved in or reguates" ; a owl:ObjectProperty ; rdfs:label "involved in or involved in regulation of" ; rdfs:subPropertyOf obo:RO_0002264, obo:RO_0002328, obo:RO_0002500 . obo:RO_0002432 obo:IAO_0000112 "A protein that enables activity in a cytosol." ; obo:IAO_0000115 "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." ; obo:IAO_0000117 ; obo:IAO_0000118 "executes activity in" ; oboInOwl:hasExactSynonym "enables activity in" ; a owl:ObjectProperty ; rdfs:comment "" ; rdfs:label "is active in" ; rdfs:seeAlso "https://wiki.geneontology.org/Is_active_in"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002131, obo:RO_0002328 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000066 ) . obo:RO_0002433 obo:IAO_0000115 "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002433" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "contributes_to_morphology_of" ; oboInOwl:shorthand "contributes_to_morphology_of" ; a owl:ObjectProperty ; rdfs:label "contributes to morphology of" ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002434 obo:IAO_0000115 "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ; obo:IAO_0000116 "Considering relabeling as 'pairwise interacts with'"^^xsd:anyURI, "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." ; obo:IAO_0000117 ; obo:IAO_0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." ; oboInOwl:hasExactSynonym "in pairwise interaction with" ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "interacts with" ; rdfs:range obo:BFO_0000040 ; rdfs:seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; skos:closeMatch "http://purl.obolibrary.org/obo/MI_0914"^^xsd:anyURI . obo:RO_0002436 obo:IAO_0000115 "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ; obo:IAO_0000117 ; obo:IAO_0000118 "binds", "molecularly binds with" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "molecularly interacts with" ; rdfs:seeAlso obo:ECO_0000353 ; rdfs:subPropertyOf obo:RO_0002434 ; skos:closeMatch "http://purl.obolibrary.org/obo/MI_0915"^^xsd:anyURI . obo:RO_0002447 obo:IAO_0000116 "Axiomatization to GO to be added later" ; obo:IAO_0000117 ; obo:IAO_0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." ; a owl:ObjectProperty ; rdfs:label "phosphorylates" ; rdfs:subPropertyOf obo:RO_0002436 . obo:RO_0002448 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.""" ; obo:IAO_0000117 , ; oboInOwl:hasExactSynonym "molecularly controls" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002436, obo:RO_0011002 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002211 obo:RO_0002333 ) . obo:RO_0002449 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.""" ; obo:IAO_0000117 , ; obo:IAO_0000118 "directly inhibits" ; oboInOwl:hasExactSynonym "molecularly decreases activity of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly negatively regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002448 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002630 obo:RO_0002333 ) . obo:RO_0002450 obo:IAO_0000115 """The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.""" ; obo:IAO_0000117 , ; obo:IAO_0000118 "directly activates" ; oboInOwl:hasExactSynonym "molecularly increases activity of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "directly positively regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002448 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002629 obo:RO_0002333 ) . obo:RO_0002464 obo:IAO_0000117 ; obo:IAO_0000232 "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." ; a owl:ObjectProperty ; rdfs:label "helper property (not for use in curation)" . obo:RO_0002473 obo:IAO_0000112 "'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'" ; obo:IAO_0000115 "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:RO_0001900 obo:RO_0001901 ; oboInOwl:hasDbXref "RO:0002473" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "composed_primarily_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "composed_primarily_of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "composed primarily of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000051 . obo:RO_0002475 a owl:AnnotationProperty . obo:RO_0002479 obo:IAO_0000115 "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." ; obo:IAO_0000117 ; oboInOwl:inSubset subsets:ro-eco ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "has part that occurs in" ; rdfs:range obo:BFO_0000004 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:BFO_0000066 ) . obo:RO_0002481 obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "is kinase activity" ; rdfs:subPropertyOf obo:RO_0002564 . obo:RO_0002485 obo:IAO_0000116 "See notes for inverse relation" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "receives input from" ; rdfs:subPropertyOf obo:RO_0002170 ; owl:inverseOf obo:RO_0002486 . obo:RO_0002486 obo:IAO_0000116 "This is an exploratory relation. The label is taken from the FMA. It needs aligned with the neuron-specific relations such as has postsynaptic terminal in." ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "sends output to" ; rdfs:subPropertyOf obo:RO_0002170 . obo:RO_0002487 obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000004 ; rdfs:label "relation between physical entity and a process or stage" ; rdfs:range obo:BFO_0000003 . obo:RO_0002488 obo:IAO_0000115 "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002488" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_starts_during" ; oboInOwl:shorthand "existence_starts_during" ; a owl:ObjectProperty ; rdfs:label "existence starts during" ; rdfs:subPropertyOf obo:RO_0002490, obo:RO_0002496 ; owl:propertyChainAxiom (obo:RO_0002488 obo:BFO_0000050 ) . obo:RO_0002489 obo:IAO_0000115 "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002489" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_starts_with" ; oboInOwl:shorthand "existence_starts_with" ; a owl:ObjectProperty ; rdfs:label "existence starts with" ; rdfs:subPropertyOf obo:RO_0002488 . obo:RO_0002490 obo:IAO_0000115 "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence overlaps" ; rdfs:subPropertyOf obo:RO_0002487 . obo:RO_0002491 obo:IAO_0000115 "x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002491" ; oboInOwl:hasExactSynonym "exists during" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_starts_and_ends_during" ; oboInOwl:shorthand "existence_starts_and_ends_during" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence starts and ends during" ; rdfs:subPropertyOf obo:RO_0002488, obo:RO_0002492 . obo:RO_0002492 obo:IAO_0000115 "Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.", "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002492" ; oboInOwl:hasExactSynonym "ceases_to_exist_during" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_ends_during" ; oboInOwl:shorthand "existence_ends_during" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends during" ; rdfs:subPropertyOf obo:RO_0002490, obo:RO_0002497 ; owl:propertyChainAxiom (obo:RO_0002492 obo:BFO_0000050 ) . obo:RO_0002493 obo:IAO_0000115 "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002493" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_ends_with" ; oboInOwl:shorthand "existence_ends_with" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends with" ; rdfs:subPropertyOf obo:RO_0002492 . obo:RO_0002494 obo:IAO_0000115 "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002494" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "transformation_of" ; oboInOwl:shorthand "transformation_of" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "transformation of" ; rdfs:subPropertyOf obo:RO_0002202 . obo:RO_0002495 obo:IAO_0000115 "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" ; obo:IAO_0000117 ; obo:RO_0002575 obo:RO_0002494 ; oboInOwl:hasDbXref "RO:0002495" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "immediate_transformation_of" ; oboInOwl:shorthand "immediate_transformation_of" ; a owl:ObjectProperty ; rdfs:label "immediate transformation of" ; rdfs:subPropertyOf obo:RO_0002207, obo:RO_0002494 . obo:RO_0002496 obo:IAO_0000115 "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002496" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_starts_during_or_after" ; oboInOwl:shorthand "existence_starts_during_or_after" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence starts during or after" ; rdfs:subPropertyOf obo:RO_0002487 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002496 ), (obo:RO_0002258 obo:RO_0002496 ), (obo:RO_0002496 obo:BFO_0000050 ), (obo:RO_0002496 obo:BFO_0000062 ), (obo:RO_0002496 obo:RO_0002082 ) . obo:RO_0002497 obo:IAO_0000115 "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002497" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "existence_ends_during_or_before" ; oboInOwl:shorthand "existence_ends_during_or_before" ; a owl:ObjectProperty ; rdfs:comment "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ; rdfs:label "existence ends during or before" ; rdfs:subPropertyOf obo:RO_0002487 ; owl:propertyChainAxiom (obo:BFO_0000050 obo:RO_0002497 ), (obo:RO_0002286 obo:RO_0002497 ), (obo:RO_0002497 obo:BFO_0000050 ), (obo:RO_0002497 obo:BFO_0000063 ), (obo:RO_0002497 obo:RO_0002082 ) . obo:RO_0002500 obo:IAO_0000115 "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "causal agent in process" ; rdfs:subPropertyOf obo:RO_0002595 ; owl:inverseOf obo:RO_0002608 . obo:RO_0002501 obo:IAO_0000115 "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000003 ; rdfs:label "causal relation between processes" ; rdfs:range obo:BFO_0000003 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002502 obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "depends on" ; rdfs:seeAlso obo:BFO_0000169 . obo:RO_0002503 obo:IAO_0000115 "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" ; obo:IAO_0000116 "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." ; obo:IAO_0000117 ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002503" ; oboInOwl:id "towards" ; oboInOwl:shorthand "towards" ; a owl:ObjectProperty ; rdfs:label "towards" ; rdfs:subPropertyOf obo:RO_0002502 . obo:RO_0002506 obo:IAO_0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "causal relation between entities" ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002551 obo:IAO_0000112 "Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'" ; obo:IAO_0000115 "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." ; obo:IAO_0000117 ; obo:IAO_0000118 "has supporting framework" ; obo:IAO_0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." ; oboInOwl:hasDbXref "RO:0002551" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_skeleton" ; oboInOwl:shorthand "has_skeleton" ; a owl:AsymmetricProperty, owl:IrreflexiveProperty, owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061, obo:UBERON_0000475 ; rdfs:label "has skeleton" ; rdfs:range obo:UBERON_0000465, obo:UBERON_0010912 ; rdfs:subPropertyOf obo:BFO_0000051 ; owl:inverseOf obo:RO_0002576 . obo:RO_0002559 obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000589 "causally influenced by (entity-centric)" ; a owl:ObjectProperty ; rdfs:label "causally influenced by" ; rdfs:subPropertyOf obo:RO_0002506 ; owl:inverseOf obo:RO_0002566 . obo:RO_0002563 obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "interaction relation helper property" ; rdfs:seeAlso , "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002464 . obo:RO_0002564 obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "molecular interaction relation helper property" ; rdfs:subPropertyOf obo:RO_0002563 . obo:RO_0002566 obo:IAO_0000115 "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." ; obo:IAO_0000117 , ; obo:IAO_0000119 ; obo:IAO_0000589 "causally influences (entity-centric)" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000002 ; rdfs:label "causally influences" ; rdfs:range obo:BFO_0000002 ; rdfs:subPropertyOf obo:RO_0002506 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002411 obo:RO_0002233 ), (obo:RO_0002327 obo:RO_0002411 obo:RO_0002333 ) . obo:RO_0002567 obo:IAO_0000115 "A relation that holds between elements of a musculoskeletal system or its analogs." ; obo:IAO_0000117 ; obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "biomechanically related to" ; rdfs:range obo:UBERON_0000061 ; rdfs:subPropertyOf obo:RO_0002328 . obo:RO_0002568 obo:IAO_0000115 "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." ; obo:IAO_0000117 ; obo:IAO_0000119 "Wikipedia:Antagonist_(muscle)" ; oboInOwl:hasDbXref "RO:0002568" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_muscle_antagonist" ; oboInOwl:shorthand "has_muscle_antagonist" ; a owl:ObjectProperty ; rdfs:label "has muscle antagonist" ; rdfs:subPropertyOf obo:RO_0002567 . obo:RO_0002569 obo:IAO_0000115 "inverse of branching part of" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002569" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "has_branching_part" ; oboInOwl:inSubset obo:RO_0002259, subsets:ro-eco ; oboInOwl:shorthand "has_branching_part" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "has branching part" ; rdfs:subPropertyOf obo:BFO_0000051, obo:RO_0002375 . obo:RO_0002570 obo:IAO_0000115 "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." ; obo:IAO_0000117 ; obo:IAO_0000119 "UBERON:cjm" ; obo:IAO_0000232 "This relation holds between a thing with a 'conduit' (e.g. a bone foramen) and a 'conduee' (for example, a nerve) such that at the time the relationship holds, the conduee has two ends sticking out either end of the conduit. It should therefore note be used for objects that move through the conduit but whose spatial extent does not span the passage. For example, it would not be used for a mountain that contains a long tunnel through which trains pass. Nor would we use it for a digestive tract and objects such as food that pass through." ; oboInOwl:hasDbXref "RO:0002570" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "conduit_for" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "conduit_for" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "conduit for" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002131 . obo:RO_0002571 obo:IAO_0000115 "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." ; obo:IAO_0000117 ; obo:IAO_0000119 ; oboInOwl:hasDbXref "RO:0002571" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "lumen_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "lumen_of" ; a owl:ObjectProperty ; rdfs:label "lumen of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002572 obo:IAO_0000115 "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002572" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "luminal_space_of" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "luminal_space_of" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000141 ; rdfs:label "luminal space of" ; rdfs:subPropertyOf obo:RO_0002571 . obo:RO_0002573 obo:IAO_0000115 "A relation that holds between an attribute or a qualifier and another attribute." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000232 "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." ; oboInOwl:hasDbXref "RO:0002180" ; oboInOwl:id "qualifier" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "qualifier" ; a owl:ObjectProperty ; rdfs:comment "placeholder relation to indicate normality/abnormality." ; rdfs:domain obo:BFO_0000020 ; rdfs:label "has modifier" ; rdfs:range obo:BFO_0000020 . obo:RO_0002575 a owl:AnnotationProperty . obo:RO_0002576 obo:IAO_0000115 "inverse of has skeleton" ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0002576" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "skeleton_of" ; oboInOwl:inSubset obo:RO_0002259 ; oboInOwl:shorthand "skeleton_of" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0000061 ; rdfs:label "skeleton of" ; rdfs:range obo:UBERON_0000061 ; rdfs:subPropertyOf obo:BFO_0000050 . obo:RO_0002577 obo:IAO_0000115 "A material entity consisting of multiple components that are causally integrated." ; obo:IAO_0000116 "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" ; obo:IAO_0000117 ; obo:IAO_0000119 "http://www.jbiomedsem.com/content/4/1/43" ; a owl:Class ; rdfs:label "system" ; rdfs:subClassOf obo:BFO_0000040 . obo:RO_0002578 obo:IAO_0000115 "p directly regulates q iff p is immediately causally upstream of q and p regulates q." ; obo:IAO_0000117 ; obo:IAO_0000119 ; obo:IAO_0000589 "directly regulates (processual)" ; obo:RO_0002575 obo:RO_0002211 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly regulates" ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002412 . obo:RO_0002579 a owl:AnnotationProperty . obo:RO_0002581 obo:IAO_0000115 "If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL" ; a owl:AnnotationProperty ; rdfs:label "is a defining property chain axiom" . obo:RO_0002582 obo:IAO_0000115 "If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R." ; a owl:AnnotationProperty ; rdfs:label "is a defining property chain axiom where second argument is reflexive" . obo:RO_0002584 obo:IAO_0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" ; obo:IAO_0000115 "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:label "has part structure that is capable of" ; rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002595 ; owl:propertyChainAxiom (obo:BFO_0000051 obo:RO_0002215 ) . obo:RO_0002595 obo:IAO_0000115 "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ; obo:IAO_0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ; obo:IAO_0000117 ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "causal relation between material entity and a process" ; rdfs:range obo:BFO_0000015 ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002596 obo:IAO_0000112 "pyrethroid -> growth" ; obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of regulating" ; rdfs:subPropertyOf obo:RO_0002500 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002211 ) . obo:RO_0002597 obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of negatively regulating" ; rdfs:subPropertyOf obo:RO_0002596 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002212 ) . obo:RO_0002598 obo:IAO_0000112 "renin -> arteriolar smooth muscle contraction" ; obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "capable of positively regulating" ; rdfs:subPropertyOf obo:RO_0002596 ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002213 ) . obo:RO_0002604 a owl:AnnotationProperty . obo:RO_0002608 obo:IAO_0000115 "Inverse of 'causal agent in process'" ; obo:IAO_0000119 ; a owl:ObjectProperty ; rdfs:label "process has causal agent" ; rdfs:subPropertyOf obo:RO_0002410 . obo:RO_0002610 obo:IAO_0000115 "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ; obo:IAO_0000232 "Groups both positive and negative correlation" ; a owl:ObjectProperty ; rdfs:label "correlated with" . obo:RO_0002629 obo:IAO_0000115 "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." ; obo:IAO_0000119 ; obo:IAO_0000589 "directly positively regulates (process to process)" ; obo:RO_0004049 obo:RO_0002578 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly positively regulates" ; rdfs:seeAlso "https://wiki.geneontology.org/Directly_positively_regulates"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002213, obo:RO_0002578 . obo:RO_0002630 obo:IAO_0000115 "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." ; obo:IAO_0000119 ; obo:IAO_0000589 "directly negatively regulates (process to process)" ; obo:RO_0004050 obo:RO_0002578 ; oboInOwl:inSubset obo:valid_for_go_annotation_extension, obo:valid_for_go_ontology, obo:valid_for_gocam ; a owl:ObjectProperty ; rdfs:label "directly negatively regulates" ; rdfs:seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002212, obo:RO_0002578 . obo:RO_0003000 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0003000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "produces" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "produces" ; a owl:ObjectProperty ; rdfs:comment "Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue." ; rdfs:domain obo:BFO_0000040 ; rdfs:label "produces", "produces"@en ; rdfs:range obo:BFO_0000040 ; owl:inverseOf obo:RO_0003001 ; owl:propertyChainAxiom ([ owl:inverseOf obo:BFO_0000066 ] obo:RO_0002234 ) . obo:RO_0003001 obo:IAO_0000114 obo:IAO_0000125 ; obo:IAO_0000115 "a produced_by b iff some process that occurs_in b has_output a." ; obo:IAO_0000117 ; oboInOwl:hasDbXref "RO:0003001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "produced_by" ; oboInOwl:inSubset subsets:ro-eco ; oboInOwl:shorthand "produced_by" ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "produced by", "produced by"@en ; rdfs:range obo:BFO_0000040 . obo:RO_0004031 obo:IAO_0000115 "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ; oboInOwl:created_by ; oboInOwl:creation_date "2018-01-25T23:20:13Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "enables subfunction" ; rdfs:subPropertyOf obo:RO_0002328 ; owl:propertyChainAxiom (obo:RO_0002327 obo:BFO_0000051 ) . obo:RO_0004032 obo:RO_0004049 obo:RO_0002264 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-01-26T23:49:30Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within, positive effect" ; rdfs:seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0004047 ) . obo:RO_0004033 obo:RO_0004050 obo:RO_0002264 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-01-26T23:49:51Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of or within, negative effect" ; rdfs:seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002264 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0004046 ) . obo:RO_0004034 obo:IAO_0000115 "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ; obo:RO_0004049 obo:RO_0002263 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-01-26T23:53:14Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of, positive effect" ; rdfs:seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004032 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002304 ) . obo:RO_0004035 obo:IAO_0000115 "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ; obo:RO_0004050 obo:RO_0002263 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-01-26T23:53:22Z"^^xsd:dateTime ; oboInOwl:inSubset obo:valid_for_go_gp2term ; a owl:ObjectProperty ; rdfs:label "acts upstream of, negative effect" ; rdfs:seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004033 ; owl:propertyChainAxiom (obo:RO_0002327 obo:RO_0002305 ) . obo:RO_0004036 a owl:AnnotationProperty . obo:RO_0004046 obo:RO_0004050 obo:RO_0002418 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-03-13T23:55:05Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "causally upstream of or within, negative effect" ; rdfs:seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect"^^xsd:anyURI ; rdfs:subPropertyOf obo:RO_0002418 . obo:RO_0004047 obo:RO_0004049 obo:RO_0002418 ; oboInOwl:created_by ; oboInOwl:creation_date "2018-03-13T23:55:19Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "causally upstream of or within, positive effect" ; rdfs:seeAlso ; rdfs:subPropertyOf obo:RO_0002418 . obo:RO_0004049 a owl:AnnotationProperty . obo:RO_0004050 a owl:AnnotationProperty . obo:RO_0011002 obo:IAO_0000115 "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." ; obo:IAO_0000117 ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000040 ; rdfs:label "regulates activity of" ; rdfs:range obo:BFO_0000040 ; rdfs:subPropertyOf obo:RO_0002566 . obo:RO_0012011 obo:IAO_0000115 "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." ; oboInOwl:created_by ; oboInOwl:creation_date "2022-09-26T06:07:17Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "indirectly causally upstream of"@en ; rdfs:subPropertyOf obo:RO_0002411 . obo:RO_0012012 obo:IAO_0000115 "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." ; oboInOwl:created_by ; oboInOwl:creation_date "2022-09-26T06:08:01Z"^^xsd:dateTime ; a owl:ObjectProperty ; rdfs:label "indirectly regulates"@en ; rdfs:subPropertyOf obo:RO_0002211, obo:RO_0012011 . obo:RO_0015006 obo:IAO_0000115 "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ; a owl:ObjectProperty ; rdfs:domain obo:PATO_0000001 ; rdfs:label "different in magnitude relative to" ; rdfs:range obo:PATO_0000001 . obo:RO_0015007 obo:IAO_0000115 "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ; a owl:ObjectProperty ; rdfs:comment "This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'." ; rdfs:domain obo:PATO_0000001 ; rdfs:label "increased in magnitude relative to" ; rdfs:range obo:PATO_0000001 ; rdfs:subPropertyOf obo:RO_0015006 . obo:RO_0015008 obo:IAO_0000115 "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ; a owl:ObjectProperty ; rdfs:comment "This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'." ; rdfs:domain obo:PATO_0000001 ; rdfs:label "decreased in magnitude relative to" ; rdfs:range obo:PATO_0000001 ; rdfs:subPropertyOf obo:RO_0015006 . obo:RO_0015010 a owl:ObjectProperty ; rdfs:label "has relative magnitude" . obo:RO_0015011 obo:IAO_0000115 "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." ; a owl:ObjectProperty ; rdfs:comment "Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round." ; rdfs:label "has cross section" . obo:RO_0015012 obo:IAO_0000115 "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." ; a owl:ObjectProperty ; rdfs:comment "There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality." ; rdfs:label "reciprocal of" . obo:RO_0015015 obo:IAO_0000112 "'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')" ; obo:IAO_0000115 "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." ; dcterms:contributor , ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000000 ; rdfs:label "has high plasma membrane amount" ; rdfs:subPropertyOf obo:RO_0002104 . obo:RO_0015016 obo:IAO_0000112 "'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')" ; obo:IAO_0000115 "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." ; dcterms:contributor , ; a owl:ObjectProperty ; rdfs:domain obo:CL_0000000 ; rdfs:label "has low plasma membrane amount" ; rdfs:subPropertyOf obo:RO_0002104 . obo:RO_0017001 obo:IAO_0000112 "A diagnostic testing device utilizes a specimen." ; obo:IAO_0000115 "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." ; obo:IAO_0000117 , ; obo:IAO_0000232 "A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input.", "See github ticket https://github.com/oborel/obo-relations/issues/497" ; oboInOwl:creation_date "2021-11-08T12:00:00Z" ; oboInOwl:hasBroadSynonym "utilizes" ; a owl:ObjectProperty ; rdfs:label "device utilizes material"@en ; owl:propertyChainAxiom (obo:RO_0002215 obo:RO_0002233 ) . obo:RO_0017003 obo:IAO_0000115 "A relation between entities in which one increases or decreases as the other does the same."@en ; obo:IAO_0000118 "directly correlated with"@en ; dcterms:contributor ; a owl:ObjectProperty, owl:ReflexiveProperty, owl:SymmetricProperty ; rdfs:label "positively correlated with"@en ; rdfs:subPropertyOf obo:RO_0002610 . obo:RO_0019000 obo:IAO_0000115 "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." ; dcterms:contributor ; a owl:ObjectProperty ; rdfs:domain obo:BFO_0000015 ; rdfs:label "regulates characteristic" ; rdfs:range obo:PATO_0000001 ; rdfs:subPropertyOf obo:RO_0002410 ; owl:propertyChainAxiom (obo:RO_0002211 obo:RO_0019000 ) . obo:RO_0019001 obo:IAO_0000115 "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." ; dcterms:contributor ; a owl:ObjectProperty ; rdfs:label "positively regulates characteristic" ; rdfs:subPropertyOf obo:RO_0019000 ; owl:propertyChainAxiom (obo:RO_0002213 obo:RO_0019001 ) . obo:RO_0019002 obo:IAO_0000115 "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." ; dcterms:contributor ; a owl:ObjectProperty ; rdfs:label "negatively regulates characteristic" ; rdfs:subPropertyOf obo:RO_0019000 ; owl:propertyChainAxiom (obo:RO_0002212 obo:RO_0019001 ), (obo:RO_0002213 obo:RO_0019002 ) . obo:RO_0040042 a owl:AnnotationProperty . obo:UBERON_0000000 obo:IAO_0000115 "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000000" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "processual entity" ; owl:disjointWith obo:UBERON_0001062 . obo:UBERON_0000002 obo:IAO_0000115 "Lower, narrow portion of the uterus where it joins with the top end of the vagina." ; obo:UBPROP_0000001 "The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG]" ; obo:UBPROP_0000003 "The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG]" ; obo:UBPROP_0000007 "cervical" ; oboInOwl:hasBroadSynonym "cervix" ; oboInOwl:hasDbXref "BTO:0001421", "BTO:0002249", "CALOHA:TS-0134", "EFO:0000979", "EMAPA:29927", "EV:0100114", "FMA:17740", "GAID:376", "MA:0000392", "MAT:0000292", "MESH:D002584", "NCIT:C12311", "SCTID:181453009", "UMLS:C0007874", "VHOG:0001359", "Wikipedia:Cervix", "galen:CervixUteri" ; oboInOwl:hasExactSynonym "canalis cervicis uteri", "caudal segment of uterus", "cervical canal of uterus", "cervix uteri", "neck of uterus", "uterine cervix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervical canal", "cervix of uterus" ; oboInOwl:id "UBERON:0000002" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "uterine cervix" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0000003 obo:IAO_0000115 "Orifice of the olfactory system. The naris is the route by which odorants enter the olfactory system[MAH]." ; obo:UBPROP_0000001 "One of paired external openings of the nasal chamber.[AAO]" ; obo:UBPROP_0000003 "Naris refer to the external and interior naris (choana) of tetrapods, and to anterior and posterior naris of zebrafish. It seems now accepted that the structure is homologous: The choana, a unique 'internal nostril' opening from the nasal sac into the roof of the mouth, is a key part of the tetrapod (land vertebrate) respiratory system. It was the first component of the tetrapod body plan to evolve, well before the origin of limbs, and is therefore crucial to our understanding of the beginning of the fish-tetrapod transition. (...) Here we present new material of Kenichthys, a 395-million-year-old fossil fish from China, that provides direct evidence for the origin of the choana and establishes its homology: it is indeed a displaced posterior external nostril that, during a brief transitional stage illustrated by Kenichthys, separated the maxilla from the premaxilla.[well established][VHOG]" ; obo:UBPROP_0000008 "in actinopterygians, both pairs of nares are external. In tetrapods, the exhalant empties into the buccal cavity" ; obo:UBPROP_0000012 "we have classified this as an orifice, according to FMA. Note that in FMA, orifices are immaterial entities, but in ZFA this is a surface structure" ; oboInOwl:hasDbXref "AAO:0000311", "EHDAA2:0001225", "EHDAA:9083", "EMAPA:17847", "MA:0000282", "SCTID:272650008", "VHOG:0000663", "galen:Naris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000003" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "naris" ; rdfs:subClassOf _:genid110827 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005725 ] _:genid110827 ) ] . obo:UBERON_0000004 obo:IAO_0000115 "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity." ; obo:UBPROP_0000001 "Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047].", "a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose].", "the organ that is specialized for smell and is part of the respiratory system" ; obo:UBPROP_0000008 "the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359]" ; oboInOwl:hasDbXref "BTO:0000840", "CALOHA:TS-2037", "EHDAA2:0001274", "EHDAA:1502", "EMAPA:16542", "EV:0100037", "EV:0100370", "FMA:46472", "GAID:77", "MA:0000281", "MAT:0000139", "MESH:D009666", "MIAA:0000139", "NCIT:C12756", "SCTID:181195007", "TAO:0000047", "UMLS:C0028429", "Wikipedia:Nose", "ZFA:0000047", "galen:Nose" ; oboInOwl:hasExactSynonym "nasal sac", "nose", "peripheral olfactory organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasus", "olfactory apparatus", "proboscis" ; oboInOwl:id "UBERON:0000004" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nose" ; rdfs:subClassOf obo:UBERON_0002268, _:genid110833, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007608 ], _:genid110835, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0006813 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg"^^xsd:anyURI . obo:UBERON_0000005 oboInOwl:hasDbXref "FBbt:00005157" ; oboInOwl:hasExactSynonym "chemosensory sensory organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000005" ; oboInOwl:inSubset core:functional_classification, core:uberon_slim ; a owl:Class ; rdfs:label "chemosensory organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005726 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000020 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007606 ] ) ] . obo:UBERON_0000006 obo:IAO_0000115 "The clusters of hormone-producing cells that are scattered throughout the pancreas." ; obo:UBPROP_0000001 "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" ; obo:UBPROP_0000003 "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" ; obo:UBPROP_0000008 "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" ; obo:UBPROP_0000202 obo:FMA_76489 ; oboInOwl:hasDbXref "AAO:0010406", "BTO:0000991", "CALOHA:TS-0741", "EFO:0000856", "EMAPA:32927", "EV:0100130", "FMA:16016", "GAID:324", "MA:0000127", "MAT:0000076", "MESH:D007515", "MIAA:0000076", "NCIT:C12608", "UMLS:C0022131", "VHOG:0000646", "Wikipedia:Islets_of_Langerhans", "XAO:0000159" ; oboInOwl:hasExactSynonym "pancreatic insula", "pancreatic islet" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "island of Langerhans", "island of pancreas", "islets of Langerhans" ; oboInOwl:id "UBERON:0000006" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "islet of Langerhans" ; rdfs:subClassOf obo:UBERON_0034922, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000016 ], _:genid110859, _:genid110861, _:genid110863 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png"^^xsd:anyURI . obo:UBERON_0000007 obo:IAO_0000115 "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." ; obo:UBPROP_0000001 "An endocrine gland derived from infundibulum of the floor of the diencephalon and an ectodermal dorsal protrusion from the buccal cavity which controls the secretion of many hormones influencing the function of various organs of the body.[AAO]", "An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin.[TAO]" ; obo:UBPROP_0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" ; obo:UBPROP_0000008 "The lamprey possesses a distinct pituitary organ and hormones, the ascidian does not show distinct evidence of them [Sower S, Freamat M, Kavanaugh S. The origins of the vertebrate hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-thyroid (HPT) endocrine systems: new insights from lampreys. Gen Comp Endocrinol 2009;161:20-9]" ; oboInOwl:hasBroadSynonym "Hp" ; oboInOwl:hasDbXref "AAO:0010536", "BAMS:PIT", "BAMS:Pit", "BIRNLEX:1353", "BM:Die-Hy-HY", "BTO:0001073", "CALOHA:TS-0798", "DHBA:10505", "EFO:0000857", "EHDAA2:0001471", "EHDAA:2183", "EHDAA:4477", "EMAPA:35998", "EV:0100132", "FMA:13889", "GAID:457", "HBA:4634", "MA:0000176", "MAT:0000077", "MESH:D010902", "MIAA:0000077", "NCIT:C12399", "SCTID:181125003", "TAO:0000118", "UMLS:C0032005", "VHOG:0000143", "Wikipedia:Pituitary_gland", "XAO:0000017", "ZFA:0000118", "neuronames:399" ; oboInOwl:hasExactSynonym "glandula pituitaria", "pituitary", "pituitary body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hypophysis", "hypophysis cerebri" ; oboInOwl:id "UBERON:0000007" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Terminology note: hypophysis and pituitary gland are often used informally as synonyms, but the hypophysis also includes the small infundibular or pituitary stalk[Neumann 2020]" ; rdfs:label "pituitary gland" ; rdfs:subClassOf obo:UBERON_0002368, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002196 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002198 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007276 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001894 ], _:genid110874, _:genid110876, _:genid110878, _:genid110884 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png"^^xsd:anyURI . obo:UBERON_0000009 obo:IAO_0000115 "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." ; obo:UBPROP_0000007 "submucosal" ; oboInOwl:hasDbXref "BTO:0002107", "FMA:85391", "FMA:85392", "NCIT:C13167", "SCTID:68439008", "UMLS:C0225344", "Wikipedia:Submucosa" ; oboInOwl:hasExactSynonym "organ submucosa", "region of submucosa", "submucosa of organ", "submucosa of region of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer", "tela submucosa", "tunica submucosa" ; oboInOwl:id "UBERON:0000009" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "submucosa" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0000344 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png"^^xsd:anyURI . obo:UBERON_0000010 obo:IAO_0000115 "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." ; obo:UBPROP_0000001 "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]", "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]", "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" ; obo:UBPROP_0000003 "(...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "PNS" ; oboInOwl:hasDbXref "AAO:0000429", "BAMS:PNS", "BILA:0000081", "BIRNLEX:1111", "BTO:0001028", "CALOHA:TS-0808", "EFO:0000891", "EHDAA2:0001445", "EHDAA:2893", "EMAPA:16665", "EV:0100335", "FBbt:00005098", "FMA:9903", "GAID:715", "MA:0000218", "MAT:0000338", "MESH:D017933", "MIAA:0000338", "NCIT:C12465", "SCTID:362292005", "TAO:0000142", "UMLS:C0206417", "UMLS:C1305921", "VHOG:0000399", "Wikipedia:Peripheral_nervous_system", "XAO:0000178", "ZFA:0000142", "neuronames:3232" ; oboInOwl:hasExactSynonym "pars peripherica", "systema nervosum periphericum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000010" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "peripheral nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png"^^xsd:anyURI . obo:UBERON_0000011 obo:IAO_0000115 "The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO]." ; obo:UBPROP_0000001 "Part of the autonomic nervous system which has opposing physiological effects of the sympathetic nervous system. Examples include decreasing the heart rate or dilating the blood vessels.[AAO]" ; obo:UBPROP_0000003 "In mammals, the autonomic nervous system is divided into two contrasting, antagonistic systems of control over visceral activity: the sympathetic system and the parasympathetic system (reference 1); In general, the teleosts may be considered phylogenetically the first class of vertebrates in which the heart is regulated by both sympathetic and parasympathetic neural pathways (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010488", "BIRNLEX:2517", "BTO:0001833", "CALOHA:TS-2094", "EFO:0000894", "EHDA:10096", "EHDAA2:0001402", "EHDAA:4655", "EMAPA:17270", "FMA:9907", "GAID:708", "MA:0000223", "MAT:0000101", "MESH:D010275", "MIAA:0000101", "NCIT:C12764", "SCTID:362496006", "TAO:0001575", "UMLS:C0030510", "UMLS:C1305770", "VHOG:0000755", "Wikipedia:Parasympathetic_nervous_system", "ZFA:0001575" ; oboInOwl:hasExactSynonym "PNS - parasympathetic", "parasympathetic part of autonomic division of nervous system", "pars parasympathica divisionis autonomici systematis nervosi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pars parasympathica divisionis autonomici systematis nervosi" ; oboInOwl:id "UBERON:0000011" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "parasympathetic nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002410 ], _:genid110921, _:genid110923 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png"^^xsd:anyURI . obo:UBERON_0000012 obo:IAO_0000115 "Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors." ; oboInOwl:hasDbXref "EFO:0000892", "FMA:9904", "MA:0002850", "MAT:0000099", "MIAA:0000099", "NLXANAT:100301", "Wikipedia:Somatic_nervous_system" ; oboInOwl:hasExactSynonym "PNS - somatic", "somatic nervous system, somatic division", "somatic part of peripheral nervous system", "somatic peripheral nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000012" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "somatic nervous system" ; rdfs:subClassOf obo:UBERON_0011216, _:genid110923, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0000013 obo:IAO_0000115 "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." ; obo:UBPROP_0000001 "Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO]", "The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG]" ; obo:UBPROP_0000011 "has developmental contribution from NC in verteberates (https://github.com/obophenotype/uberon/wiki/The-neural-crest)" ; oboInOwl:hasDbXref "AAO:0010487", "BIRNLEX:2516", "BTO:0001832", "CALOHA:TS-2050", "EFO:0000893", "EHDAA2:0001971", "EHDAA:3769", "EMAPA:16985", "FMA:9906", "GAID:710", "MA:0000225", "MESH:D013564", "MIAA:0000100", "NCIT:C12795", "SCTID:362484004", "TAO:0001576", "UMLS:C0039044", "UMLS:C1269646", "VHOG:0000384", "Wikipedia:Sympathetic_nervous_system", "ZFA:0001576" ; oboInOwl:hasExactSynonym "pars sympathica divisionis autonomici systematis nervosi", "sympathetic nervous system", "sympathetic part of autonomic division of nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pars sympathica divisionis autonomici systematis nervosi" ; oboInOwl:id "UBERON:0000013" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "sympathetic nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002410 ], _:genid110941 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png"^^xsd:anyURI . obo:UBERON_0000014 obo:IAO_0000115 "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." ; obo:IAO_0000232 "Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee" ; obo:UBPROP_0000003 "(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]" ; obo:UBPROP_0000012 "we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive" ; oboInOwl:hasDbXref "EHDAA2:0001844", "EHDAA:6530", "EMAPA:17525", "EV:0100152", "FMA:86166", "GAID:933", "MA:0000151", "MAT:0000284", "MESH:D012867", "MIAA:0000284", "SCTID:20795001", "VHOG:0000860", "Wikipedia:Skin" ; oboInOwl:hasExactSynonym "portion of skin", "region of skin", "skin", "skin region", "skin zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000014" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "zone of skin" ; rdfs:subClassOf obo:UBERON_0034944, _:genid110941, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002067 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg"^^xsd:anyURI . obo:UBERON_0000015 obo:IAO_0000115 "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AEO:0000192", "CARO:0000010", "FMA:50705" ; oboInOwl:hasExactSynonym "anatomical boundary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000015" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:comment "Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms." ; rdfs:label "non-material anatomical boundary" ; rdfs:subClassOf obo:UBERON_0000466 . obo:UBERON_0000016 obo:IAO_0000115 "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." ; obo:IAO_0000116 "create a separate class for distributed pancreas, eg cyclostomes?" ; obo:UBPROP_0000001 "The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]", "The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]" ; obo:UBPROP_0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" ; obo:UBPROP_0000008 "endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys" ; oboInOwl:hasDbXref "BTO:0000650", "CALOHA:TS-1302", "EFO:0002542", "EMAPA:35305", "EV:0100129", "FMA:16018", "MA:0001582", "NCIT:C32509", "SCTID:361339003", "TAO:0001260", "VHOG:0000049", "Wikipedia:Islets_of_Langerhans", "ZFA:0001260" ; oboInOwl:hasExactSynonym "endocrine pancreas", "pars endocrina pancreatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "endocrine part of pancreas", "islets of Langerhans part of pancreas" ; oboInOwl:id "UBERON:0000016" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endocrine pancreas" ; rdfs:subClassOf obo:UBERON_0000471, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001264 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000006 ], _:genid110963, _:genid110967, _:genid110969, _:genid110971 . obo:UBERON_0000017 obo:IAO_0000115 "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." ; obo:UBPROP_0000001 "The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]", "The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG]" ; obo:UBPROP_0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010407", "BTO:0000434", "CALOHA:TS-1241", "EMAPA:35328", "EV:0100093", "FMA:16017", "MA:0002415", "MESH:D046790", "NCIT:C32546", "SCTID:248202004", "TAO:0001249", "UMLS:C0553695", "VHOG:0000048", "Wikipedia:Exocrine_component_of_pancreas", "XAO:0000137", "ZFA:0001249" ; oboInOwl:hasExactSynonym "exocrine pancreas", "pars exocrina pancreatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "exocrine component of pancreas", "exocrine part of pancreas" ; oboInOwl:id "UBERON:0000017" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "exocrine pancreas" ; rdfs:subClassOf obo:UBERON_0000409, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ], _:genid110967, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001263 ], _:genid110969, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003924 ], _:genid110971, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001264 ] . obo:UBERON_0000019 obo:IAO_0000115 "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." ; obo:UBPROP_0000001 "A cavitated compound organ that transduces light waves into neural signals.[TAO]" ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; obo:UBPROP_0000012 "FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this" ; oboInOwl:hasBroadSynonym "eye" ; oboInOwl:hasDbXref "AAO:0010340", "BIRNLEX:1169", "BTO:0004688", "EHDAA2:0000484", "EHDAA:936", "EMAPA:16198", "FMA:54448", "MA:0000261", "NCIT:C12401", "SCTID:181143004", "TAO:0000107", "UMLS:C0015392", "UMLS:C1280202", "VHOG:0000275", "XAO:0000179", "ZFA:0000107" ; oboInOwl:hasExactSynonym "regio orbitalis" ; oboInOwl:hasNarrowSynonym "vertebrate eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "camera-type eye plus associated structures", "eyes", "orbital part of face", "orbital region" ; oboInOwl:id "UBERON:0000019" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "camera-type eye" ; rdfs:subClassOf obo:UBERON_0000047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000965 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid110998, _:genid111000 . obo:UBERON_0000020 obo:IAO_0000115 "An organ that is capable of transducing sensory stimulus to the nervous system." ; oboInOwl:hasDbXref "AEO:0000094", "BSA:0000121", "BTO:0000202", "CALOHA:TS-2043", "EHDAA2:0001824", "EHDAA:500", "EMAPA:35955", "FBbt:00005155", "GAID:63", "HAO:0000930", "MA:0000017", "MESH:D012679", "NCIT:C33224", "SCTID:244485009", "UMLS:C0935626", "VHOG:0001407", "WBbt:0006929" ; oboInOwl:hasExactSynonym "organ of sense organ system", "organ of sensory organ system", "organ of sensory system", "sense organ system organ", "sensory organ", "sensory organ system organ", "sensory system organ" ; oboInOwl:hasNarrowSynonym "sensillum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Sinnesorgan", "sensor" ; oboInOwl:id "UBERON:0000020" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "sense organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001032 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid110998 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png"^^xsd:anyURI . obo:UBERON_0000021 obo:IAO_0000115 "Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales." ; obo:IAO_0000116 "Mammary glands develop by similar mechanisms, and there is an argument for including them here (e.g. http://www.ncbi.nlm.nih.gov/pubmed/20484386), but these structures do not fit the current definition (lactiferous glands are part of the integumentary system in FMA). Note the FMA class is a subdivision of epidermis, which may be too restrictive for our purposes here." ; oboInOwl:hasDbXref "CALOHA:TS-0051", "FMA:71012", "SCTID:276160000" ; oboInOwl:hasExactSynonym "skin appendage" ; oboInOwl:hasNarrowSynonym "epidermal appendage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epidermal growth" ; oboInOwl:id "UBERON:0000021" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "cutaneous appendage" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002097 ] . obo:UBERON_0000025 obo:IAO_0000115 "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." ; obo:IAO_0000232 "not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)" ; obo:UBPROP_0000007 "tubular" ; oboInOwl:hasDbXref "galen:Tube" ; oboInOwl:hasExactSynonym "anatomical tube" ; oboInOwl:hasNarrowSynonym "duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000025" ; a owl:Class ; rdfs:label "tube" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0013522 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 ] ) ] . obo:UBERON_0000026 obo:IAO_0000115 "Major subdivision of an organism that protrudes from the body[DOS, CARO]." ; obo:UBPROP_0000001 "An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018].", "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]." ; obo:UBPROP_0000007 "appendicular" ; obo:UBPROP_0000008 "this is currently a subtype of organism subdivision - which would exclude feathers" ; oboInOwl:hasDbXref "AEO:0000193", "BILA:0000018", "BTO:0001492", "CARO:0010003", "EFO:0000799", "EHDAA2:0003193", "EMAPA:37283", "EV:0100155", "FBbt:00007000", "HAO:0000144", "MAT:0000023", "MESH:D005121", "MIAA:0000023", "NCIT:C61460", "UMLS:C0598782", "VSAO:0000075", "Wikipedia:Appendage", "XAO:0000218" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "appendages", "extremitaet", "extremity", "limbs/digits/tail" ; oboInOwl:id "UBERON:0000026" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "appendage" ; rdfs:subClassOf obo:UBERON_0000475 . obo:UBERON_0000029 obo:IAO_0000115 "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." ; obo:UBPROP_0000003 "Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0000784", "CALOHA:TS-0579", "EFO:0000872", "EMAPA:35523", "EV:0100050", "FMA:5034", "GAID:947", "MA:0000139", "MAT:0000442", "MESH:D008198", "NCIT:C12745", "NCIT:C33027", "SCTID:181756000", "TAO_RETIRED:0005318", "UMLS:C0024204", "VHOG:0001273", "Wikipedia:Lymph_node", "ZFA_RETIRED:0005318", "galen:Lymphnode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph gland", "nodus lymphaticus" ; oboInOwl:id "UBERON:0000029" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lymph node" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/650"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002465 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002006 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002007 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002194 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002391 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0034953 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001744 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png"^^xsd:anyURI . obo:UBERON_0000030 obo:IAO_0000115 "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." ; oboInOwl:hasDbXref "BTO:0002330", "FMA:62517", "NCIT:C32918", "SCTID:298225002", "UMLS:C1179187", "Wikipedia:Lamina_propria" ; oboInOwl:hasExactSynonym "lamina propria mucosa", "lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tunica propria" ; oboInOwl:id "UBERON:0000030" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "lamina propria" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000344 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0000483 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011825 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg"^^xsd:anyURI . obo:UBERON_0000031 obo:IAO_0000115 "A lamina propria that is part of a respiratory airway." ; oboInOwl:hasDbXref "EMAPA:35877", "FMA:265157", "MA:0001858", "NCIT:C49305", "UMLS:C1710457" ; oboInOwl:hasExactSynonym "lamina propria mucosa of trachea", "lamina propria mucosa of windpipe", "lamina propria mucosae of trachea", "lamina propria mucosae of windpipe", "lamina propria of windpipe", "trachea lamina propria", "trachea lamina propria mucosa", "trachea lamina propria mucosae", "tracheal lamina propria", "windpipe lamina propria", "windpipe lamina propria mucosa", "windpipe lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000031" ; a owl:Class ; rdfs:label "lamina propria of trachea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001005 ], _:genid111074 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001005 ] ) ] . obo:UBERON_0000033 obo:IAO_0000115 "The head is the anterior-most division of the body [GO]." ; obo:RO_0002171 obo:UBERON_0000948 ; obo:UBPROP_0000001 "Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]", "Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]" ; obo:UBPROP_0000003 "Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010335", "AEO:0000106", "BILA:0000115", "BIRNLEX:1230", "BTO:0000282", "CALOHA:TS-0436", "EFO:0000964", "EHDAA2:0003106", "EMAPA:31858", "FBbt:00000004", "FMA:7154", "GAID:61", "HAO:0000397", "MA:0000023", "MAT:0000294", "MESH:D006257", "MIAA:0000294", "NCIT:C12419", "SCTID:302548004", "SPD:0000016", "TAO:0001114", "TGMA:0000002", "UMLS:C0018670", "VHOG:0001644", "WBbt:0005739", "Wikipedia:Head", "XAO:0003024", "ZFA:0001114", "galen:Head" ; oboInOwl:hasExactSynonym "head (volume)" ; oboInOwl:hasNarrowSynonym "adult head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cephalic area" ; oboInOwl:id "UBERON:0000033" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "head" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] . obo:UBERON_0000042 obo:IAO_0000115 "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." ; obo:UBPROP_0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]", "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" ; obo:UBPROP_0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." ; oboInOwl:hasDbXref "FMA:9581", "GAID:19", "MESH:D012704", "NCIT:C13169", "SCTID:362878009", "TAO:0005425", "UMLS:C0036760", "Wikipedia:Serous_membrane", "ZFA:0005425" ; oboInOwl:hasExactSynonym "tunica serosa", "wall of serous sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "serosa" ; oboInOwl:id "UBERON:0000042" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "serous membrane" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000060 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001136 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ], _:genid111101 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png"^^xsd:anyURI . obo:UBERON_0000043 obo:IAO_0000115 "Dense regular connective tissue that connects muscle to bone[VSAO]." ; obo:UBPROP_0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" ; obo:UBPROP_0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" ; obo:UBPROP_0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" ; oboInOwl:hasDbXref "AEO:0000091", "BTO:0001356", "CALOHA:TS-1021", "EHDAA2:0003091", "EMAPA:35854", "EV:0100149", "FMA:9721", "GAID:276", "MA:0000115", "MESH:D013710", "NCIT:C13045", "SCTID:256667004", "UMLS:C0039508", "VHOG:0001286", "VSAO:0000073", "Wikipedia:Tendon", "XAO:0000173", "ZFA:0005647", "galen:Tendon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinew", "tendo" ; oboInOwl:id "UBERON:0000043" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tendon" ; rdfs:subClassOf obo:UBERON_0007846, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001630 ], _:genid111112, _:genid111114, _:genid111116 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg"^^xsd:anyURI . obo:UBERON_0000045 obo:IAO_0000115 "A biological tissue mass, most commonly a mass of nerve cell bodies." ; obo:IAO_0000116 "TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system." ; obo:UBPROP_0000001 "A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures", "Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]", "Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]", "Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302]." ; obo:UBPROP_0000003 "Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "ganglionic" ; oboInOwl:hasDbXref "AAO:0010426", "AEO:0000135", "BAMS:G", "BTO:0000497", "CALOHA:TS-0397", "EFO:0000899", "EHDAA2:0003135", "EHDAA:2897", "EHDAA:4662", "EHDAA:5621", "EHDAA:918", "EMAPA:32846", "EV:0100372", "FMA:5884", "MA:0002406", "MAT:0000207", "MAT:0000343", "MESH:D005724", "MIAA:0000207", "MIAA:0000343", "NCIT:C12719", "NLXANAT:100302", "TAO:0000190", "TGMA:0001016", "UMLS:C0017067", "VHOG:0000156", "WBbt:0005189", "Wikipedia:Ganglion", "XAO:0000209", "ZFA:0000190" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglia", "neural ganglion" ; oboInOwl:id "UBERON:0000045" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ganglion" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ], _:genid111129, _:genid111131 ; owl:disjointWith obo:UBERON_0002420 . obo:UBERON_0000047 obo:IAO_0000115 "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." ; oboInOwl:hasDbXref "TGMA:0000729", "Wikipedia:Eye#Simple_eyes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000047" ; oboInOwl:inSubset core:grouping_class, core:uberon_slim ; a owl:Class ; rdfs:label "simple eye" ; rdfs:subClassOf obo:UBERON_0000970 . obo:UBERON_0000053 obo:IAO_0000115 "An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)." ; oboInOwl:hasDbXref "BIRNLEX:2540", "BTO:0003015", "EMAPA:36516", "EV:0100349", "FMA:58637", "GAID:909", "MA:0001306", "MESH:D008266", "NCIT:C26464", "NCIT:C33044", "SCTID:362517001", "UMLS:C0450295", "UMLS:C1284755", "Wikipedia:Macula_of_retina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "macula", "macula flava retinae", "macula retinae", "maculae" ; oboInOwl:id "UBERON:0000053" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "macula lutea" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ; owl:disjointWith obo:UBERON_0000054 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png"^^xsd:anyURI . obo:UBERON_0000054 obo:IAO_0000115 "Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified]." ; obo:IAO_0000232 "this refers to the inner ear structure, not the macula of the retina. We follow ZFA in including a grouping class for the macula of utricle and sacule" ; obo:UBPROP_0000001 "Patches of thickened, pseudostratified epithelium of the inner ear, consisting of regular arrays of sensory hair cells interspersed with supporting cells. Each patch has its own charcteristic shape and polarity pattern. (See Anatomical Atlas entry for sensory patches of the ear by T. Whitfield.)[TAO]" ; obo:UBPROP_0000007 "macular" ; oboInOwl:hasDbXref "GAID:777", "MESH:D008267", "TAO:0000386", "ZFA:0000386" ; oboInOwl:hasExactSynonym "macula", "maculae", "sensory macula", "sensory patch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acoustic macula", "acoustic maculae" ; oboInOwl:id "UBERON:0000054" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "macula" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0070451 ] . obo:UBERON_0000055 obo:IAO_0000115 "A tubular structure that contains, conveys body fluid, such as blood or lymph." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000055" ; oboInOwl:inSubset core:grouping_class, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "vessel" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0006314 ] . obo:UBERON_0000056 obo:IAO_0000115 "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." ; obo:UBPROP_0000001 "Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]", "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" ; obo:UBPROP_0000007 "ureteral", "ureteric" ; obo:UBPROP_0000010 "in humans, consists of adventitial, muscular and mucoa layers" ; oboInOwl:hasDbXref "AAO:0010254", "BTO:0001409", "CALOHA:TS-1084", "EFO:0000930", "EHDAA2:0002139", "EHDAA:9341", "EMAPA:17950", "EV:0100097", "FMA:9704", "GAID:438", "MA:0000378", "MAT:0000120", "MESH:D014513", "MIAA:0000120", "NCIT:C12416", "SCTID:302511008", "UMLS:C0041951", "VHOG:0000605", "Wikipedia:Ureter", "XAO:0000144", "galen:Ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metanephric duct" ; oboInOwl:id "UBERON:0000056" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ureter" ; rdfs:subClassOf obo:UBERON_0000025, obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036295 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001088 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001224 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001255 ], _:genid111160, _:genid111162, _:genid111166 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg"^^xsd:anyURI . obo:UBERON_0000057 obo:IAO_0000115 "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." ; obo:UBPROP_0000007 "urethral" ; obo:UBPROP_0000008 "In human males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening." ; oboInOwl:hasDbXref "BTO:0001426", "CALOHA:TS-1132", "EFO:0000931", "EMAPA:30901", "EV:0100099", "FMA:19667", "GAID:390", "MA:0000379", "MAT:0000121", "MESH:D014521", "MIAA:0000121", "NCIT:C12417", "SCTID:302513006", "UMLS:C0041967", "VHOG:0001264", "Wikipedia:Urethra", "XAO:0000153", "galen:Urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000057" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "urethra" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001255 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0060073 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001088 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001255 ], _:genid111179, _:genid111181 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png"^^xsd:anyURI . obo:UBERON_0000058 obo:IAO_0000115 "A tubular structure that transports secreted or excreted substances." ; obo:UBPROP_0000001 "A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]." ; obo:UBPROP_0000012 "Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here." ; oboInOwl:hasDbXref "AAO:0011123", "FBbt:00100314", "FMA:30320", "NCIT:C12948", "SCTID:91726008", "TAO:0005171", "UMLS:C0687028", "Wikipedia:Duct_(anatomy)", "XAO:0004000", "ZFA:0005171", "galen:Duct" ; oboInOwl:hasExactSynonym "anatomical duct" ; oboInOwl:hasNarrowSynonym "exocrine duct", "exocrine gland duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ducts" ; oboInOwl:id "UBERON:0000058" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "duct" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0013686 ], _:genid111160, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 ], _:genid111162 . obo:UBERON_0000059 obo:IAO_0000115 "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." ; obo:UBPROP_0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010396", "BTO:0000706", "CALOHA:TS-1306", "EFO:0000840", "EMAPA:19252", "EV:0100077", "FMA:7201", "GAID:306", "MA:0000333", "MESH:D007420", "MIAA:0000046", "NCIT:C12379", "SCTID:181254001", "UMLS:C0021851", "VHOG:0000054", "Wikipedia:Large_intestine_(anatomy)", "XAO:0000131", "galen:LargeIntestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinum crassum" ; oboInOwl:id "UBERON:0000059" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "large intestine" ; rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004907 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000160 ] . obo:UBERON_0000060 obo:IAO_0000115 "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." ; obo:UBPROP_0000012 "in FMA, serosa is a wall" ; oboInOwl:hasAlternativeId "UBERON:0009915" ; oboInOwl:hasBroadSynonym "wall" ; oboInOwl:hasDbXref "EMAPA:25036", "FMA:82482", "galen:Wall" ; oboInOwl:hasExactSynonym "wall of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organ wall" ; oboInOwl:id "UBERON:0000060" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "anatomical wall" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004923 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002553 ] . obo:UBERON_0000061 obo:IAO_0000115 "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010825", "AEO:0000003", "BILA:0000003", "CARO:0000003", "EHDAA2:0003003", "EMAPA:0", "FBbt:00007001", "FMA:305751", "FMA:67135", "GAID:781", "HAO:0000003", "MA:0003000", "MESH:D000825", "SCTID:362889002", "TAO:0000037", "TGMA:0001823", "VHOG:0001759", "XAO:0003000", "ZFA:0000037", "http://dbpedia.org/ontology/AnatomicalStructure" ; oboInOwl:hasExactSynonym "biological structure", "connected biological structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000061" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical structure" ; rdfs:subClassOf obo:UBERON_0000465, _:genid111181 . obo:UBERON_0000062 obo:IAO_0000115 "Anatomical structure that performs a specific function or group of functions [WP]." ; obo:RO_0002161 obo:NCBITaxon_110815 ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000001 "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." ; obo:UBPROP_0000012 "CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4" ; oboInOwl:hasDbXref "BIRNLEX:4", "CARO:0020004", "EFO:0000634", "EMAPA:35949", "ENVO:01000162", "FMA:67498", "MA:0003001", "NCIT:C13018", "SCTID:272625005", "UMLS:C0178784", "WBbt:0003760", "Wikipedia:Organ_(anatomy)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomical unit", "body organ", "element" ; oboInOwl:id "UBERON:0000062" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "organ" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000467 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002002 ; owl:someValuesFrom obo:UBERON_0006984 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008150 ] ; owl:disjointWith obo:UBERON_0002095, obo:UBERON_0034921 . obo:UBERON_0000063 obo:IAO_0000115 "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." ; obo:IAO_0000116 "FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction" ; obo:UBPROP_0000001 "Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball.", "Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal." ; oboInOwl:hasDbXref "FMA:86140" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organ region with fixed fiat boundary", "organ segment", "segment of organ" ; oboInOwl:id "UBERON:0000063" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "organ subunit" ; rdfs:subClassOf obo:UBERON_0000064 . obo:UBERON_0000064 obo:IAO_0000115 "A multicellular structure that is a part of an organ." ; obo:IAO_0000232 "currently defined in a very broad sense, may be replaced by more specific classes in the future" ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0011124", "BIRNLEX:16", "EFO:0000635", "FMA:82472", "SCTID:113343008", "SCTID:91717005" ; oboInOwl:hasExactSynonym "cardinal organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "regional part of organ" ; oboInOwl:id "UBERON:0000064" ; oboInOwl:inSubset core:common_anatomy, core:efo_slim, core:non_informative, core:upper_level ; a owl:Class ; rdfs:label "organ part" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000062 ] . obo:UBERON_0000065 obo:IAO_0000115 "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." ; oboInOwl:hasDbXref "EHDAA2:0001606", "EHDAA:1568", "EHDAA:2219", "EMAPA:16737", "FMA:265130", "SCTID:361110005", "VHOG:0000393" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000065" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory tract" ; rdfs:subClassOf obo:UBERON_0001005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008947 ], _:genid111233 . obo:UBERON_0000066 obo:IAO_0000115 "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." ; oboInOwl:hasBroadSynonym "adult stage" ; oboInOwl:hasDbXref "BTO:0001043", "BilaDO:0000004", "EFO:0001272", "FBdv:00005369", "WBls:0000041", "XtroDO:0000084" ; oboInOwl:hasExactSynonym "fully formed animal stage", "juvenile-adult stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000066" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "fully formed stage" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/566"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000092 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000111 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000063 ; owl:someValuesFrom obo:UBERON_0000071 ] . obo:UBERON_0000068 obo:IAO_0000115 "A life cycle stage that starts with fertilization and ends with the fully formed embryo." ; oboInOwl:hasDbXref "BilaDO:0000002", "EV:0300001", "FBdv:00005289", "FMA:72652", "HsapDv:0000002", "MmusDv:0000002", "OGES:000000", "OGES:000022", "SCTID:296280003", "WBls:0000003", "WBls:0000092", "WBls:0000102", "XAO:1000012" ; oboInOwl:hasExactSynonym "embryonic stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryogenesis" ; oboInOwl:id "UBERON:0000068" ; a owl:Class ; rdfs:label "embryo stage" ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000104 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000063 ; owl:someValuesFrom obo:UBERON_0000066 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000063 ; owl:someValuesFrom obo:UBERON_0000092 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0009790 ] ; owl:disjointWith obo:UBERON_0000092 . obo:UBERON_0000071 obo:IAO_0000115 "End of the life of an organism." ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000012 "ncit:Death is an outcome" ; oboInOwl:hasDbXref "XAO:0000437", "XtroDO:0000085" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "death" ; oboInOwl:id "UBERON:0000071" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "death stage" ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000104 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002229 ; owl:someValuesFrom obo:UBERON_0000104 ] . obo:UBERON_0000072 obo:IAO_0000115 "An section of a respiratory tract." ; obo:UBPROP_0000012 "MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole" ; oboInOwl:hasDbXref "EMAPA:16737", "FMA:45660", "MA:0000434" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "respiratory tract", "subdivision of respiratory tract" ; oboInOwl:id "UBERON:0000072" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "proximo-distal subdivision of respiratory tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:UBERON_0000073 obo:IAO_0000115 "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." ; dcterms:contributor ; oboInOwl:creation_date "2009-06-18T09:00:04Z" ; oboInOwl:hasDbXref "BIRNLEX:1157", "NCIT:C13040", "SCTID:25087005", "UMLS:C1518256" ; oboInOwl:hasExactSynonym "part of nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000073" ; oboInOwl:inSubset core:non_informative, core:upper_level ; a owl:Class ; rdfs:label "regional part of nervous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0000074 obo:IAO_0000115 "A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]." ; obo:UBPROP_0000012 "ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule?" ; dcterms:contributor ; oboInOwl:creation_date "2009-06-18T09:26:37Z" ; oboInOwl:hasBroadSynonym "glomerulus" ; oboInOwl:hasDbXref "BTO:0000530", "CALOHA:TS-0862", "EFO:0003667", "EMAPA:28329", "EV:0100386", "FMA:15624", "MA:0001657", "MESH:D007678", "NCIT:C13250", "SCTID:362217000", "TAO:0001288", "UMLS:C0022663", "Wikipedia:Glomerulus", "ZFA:0001288" ; oboInOwl:hasExactSynonym "renal glomeruli" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Malphigian glomerulus", "Malpighian glomerulus", "Malpighian tuft", "glomerular capillary tuft", "glomerular tuft", "glomerulus renis", "renal corpuscle" ; oboInOwl:id "UBERON:0000074" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "renal glomerulus" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005749 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0001230 ], _:genid111264 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg"^^xsd:anyURI . obo:UBERON_0000075 obo:IAO_0000115 "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." ; oboInOwl:hasAlternativeId "UBERON:0010322" ; oboInOwl:hasDbXref "FMA:85544", "NCIT:C34076", "SCTID:118966000", "UMLS:C1519343", "galen:ComplexSkeletalStructure" ; oboInOwl:hasExactSynonym "skeletal system subdivision" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal system part" ; oboInOwl:id "UBERON:0000075" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of skeletal system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0004765 ] . obo:UBERON_0000076 obo:IAO_0000115 "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." ; obo:IAO_0000116 "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" ; obo:RO_0002171 obo:UBERON_0002346 ; obo:UBPROP_0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" ; oboInOwl:hasDbXref "EHDAA2:0001968", "EHDAA:1494", "EHDAA:350", "EHDAA:4784", "EHDAA:4790", "EHDAA:4796", "EHDAA:7860", "EMAPA:16096", "FMA:87656", "NCIT:C34309", "UMLS:C1515087", "Wikipedia:External_ectoderm" ; oboInOwl:hasExactSynonym "surface (external) ectoderm", "surface ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000076" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "external ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid111287 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png"^^xsd:anyURI . obo:UBERON_0000077 obo:IAO_0000115 "An anatomical structure that develops from the endoderm and the mesoderm." ; obo:IAO_0000232 "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000077" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "mixed endoderm/mesoderm-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] _:genid111264 ) ] . obo:UBERON_0000078 obo:IAO_0000115 "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." ; obo:IAO_0000232 "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000078" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "mixed ectoderm/mesoderm/endoderm-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ] . obo:UBERON_0000079 obo:IAO_0000115 "The organs associated with producing offspring in the gender that produces spermatozoa." ; obo:UBPROP_0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0000082", "CALOHA:TS-1310", "EFO:0000970", "EHDAA2:0001054", "EHDAA:8136", "EMAPA:17968", "EV:0100101", "FBbt:00004927", "FMA:45664", "GAID:386", "HAO:0000505", "MA:0000396", "MESH:D005837", "NCIT:C12722", "SCTID:361340001", "TGMA:0000634", "UMLS:C0017422", "UMLS:C1963704", "VHOG:0000725", "Wikipedia:Male_reproductive_system_(human)", "XAO:0000155" ; oboInOwl:hasExactSynonym "genitalia of male organism", "male genital system", "male genitalia", "male genitals", "male organism genitalia", "male organism reproductive system", "reproductive system of male organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male genital organ", "male genital tract", "male reproductive tract", "systema genitale masculinum" ; oboInOwl:id "UBERON:0000079" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "male reproductive system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ; owl:disjointWith obo:UBERON_0000474 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] . obo:UBERON_0000080 obo:IAO_0000115 "The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." ; obo:UBPROP_0000001 "A kidney formed of nephric tubules arising in the middle region of the nephric ridge; a transient embryonic stage that replaces the pronephros, but is itself replaced by the adult metanephros [in mammals; in fishes and amphibians it is the adult kidney]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]", "Organ that is the definitive adult kidney. It replaces the earlier pronephros, which degenerates as the mesonephros becomes functional in feeding stage tadpoles.[AAO]" ; obo:UBPROP_0000003 "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates. (...) In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" ; obo:UBPROP_0000007 "mesonephric" ; obo:UBPROP_0000008 "In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In fish and amphibians, the mesonephros will form the mature kidney" ; obo:UBPROP_0000009 "By contrast to the pronephros, the histological features of the mammalian mesonephros, with its primitive glomeruli, suggest that it probably functions as a primitive kidney, and is involved in the production of much of the amniotic fluid. Within the two mesonephroi, one located on either side of the dorsal mesentery of the hindgut, a substantial number (in the region of about 40 or more) of cranio-caudally segmented mesonephric tubules are formed. It has, however, been suggested that only the most rostrally located 4-6 pairs of mesonephric tubules drain into the mesonephric portion of the nephric duct. This is now seen to extend along the length of the mesonephroi, being located towards their lateral sides. The mesonephros is also retained over a considerably longer period than the pronephros, but gradually undergoes regression in a cranio-caudal direction. While the rostral part displays clear evidence of regression its more caudal part appears to display evidence of functional activity. Within the medial part of the mesonephros, vesicles are formed, although no glomeruli are formed there in this species. It is, however, difficult to believe that the relatively enormous mesonephroi do not have an excretory role in the mouse, only serving as a base for gonadal differentiation. In the human embryo, the medial part of the mesonephric tubules enlarges, become invaginated by capillaries, and form glomeruli. These then take on an excretory role. In the mouse, the mesonephric ducts appear to be patent throughout their length[GUDMAP, modified]" ; oboInOwl:hasDbXref "AAO:0010384", "BTO:0001542", "CALOHA:TS-0624", "EFO:0000928", "EHDAA2:0001130", "EHDAA:1581", "EHDAA:5903", "EMAPA:16744", "FMA:72171", "GAID:1308", "MESH:D001755", "NCIT:C26467", "SCTID:308799002", "TAO:0000529", "UMLS:C0025492", "VHOG:0000038", "Wikipedia:Mesonephros", "XAO:0000141", "ZFA:0000529" ; oboInOwl:hasExactSynonym "Wolffian body", "mesonephric kidney", "mesonephroi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "amphibian adult kidney", "corpus Wolffi", "middle kidney", "opisthonephros", "opisto nephros", "opistonephros" ; oboInOwl:id "UBERON:0000080" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesonephros" ; rdfs:subClassOf obo:UBERON_0002113, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002120 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray986.png"^^xsd:anyURI . obo:UBERON_0000081 obo:IAO_0000115 "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]." ; obo:IAO_0000116 "TODO check developmental relationships" ; obo:UBPROP_0000001 "A kidney formed of nephric tubules arising in the posterior region of the nephric ridge and drained by a ureter; replaces the embryonic pronephros and mesonephros [in mammals]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" ; obo:UBPROP_0000003 "The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes.[well established][VHOG]" ; obo:UBPROP_0000007 "metanephric" ; obo:UBPROP_0000011 "During the fifth week of gestation, the mesonephric duct develops an outpouching, the ureteric bud, near its attachment to the cloaca. This bud, also called the metanephrogenic diverticulum, grows posteriorly and towards the head of the embryo. The elongated stalk of the ureteric bud, the metanephric duct, later forms the ureter. As the cranial end of the bud extends into the intermediate mesoderm, it undergoes a series of branchings to form the collecting duct system of the kidney. It also forms the major and minor calyces and the renal pelvis" ; oboInOwl:hasDbXref "BTO:0001543", "EHDAA2:0001137", "EHDAA:3089", "EHDAA:5911", "EMAPA:17373", "EMAPA_RETIRED:17207", "FMA:72172", "NCIT:C34209", "SCTID:308797000", "UMLS:C0231049", "VHOG:0000039", "Wikipedia:Metanephros#Metanephros" ; oboInOwl:hasExactSynonym "metanephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "definite kidney", "definitive kidney", "hind kidney", "metanephric kidney" ; oboInOwl:id "UBERON:0000081" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "metanephros" ; rdfs:subClassOf obo:UBERON_0002113, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid111339, _:genid111341, _:genid111344 . obo:UBERON_0000083 obo:IAO_0000115 "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." ; obo:IAO_0000116 "TODO check" ; obo:UBPROP_0000001 "Any of the renal tubules composing the mesonephros. In mammals they function as excretory structures during the early embryonic development but are later incorporated into the reproductive system. [TFD][VHOG]" ; obo:UBPROP_0000003 "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010389", "EHDAA2:0001134", "EMAPA:16747", "VHOG:0000500", "Wikipedia:Mesonephric_tubules", "XAO:0000148" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renal tubules", "tubuli mesonephrici" ; oboInOwl:id "UBERON:0000083" ; a owl:Class ; rdfs:label "mesonephric tubule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0000084 obo:IAO_0000115 "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]." ; obo:UBPROP_0000001 "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts. [Embryology, See_Dudek_RW_and_Fix_JD, Third_Edition_(2004)_Philadelphia:_Lippincott_William_and_Wilkins, p.137][VHOG]", "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts[VHOG:0000541]." ; obo:UBPROP_0000003 "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001646", "EHDAA2:0002140", "EHDAA:3091", "EHDAA:5917", "EMAPA:17209", "NCIT:C34207", "SCTID:361528000", "UMLS:C1284058", "VHOG:0000541", "Wikipedia:Ureteric_bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diverticulum", "diverticulum metanephricum", "gemma ureterica", "metanephric bud", "metanephric diverticulum", "ureteric ampulla", "ureteric diverticulum" ; oboInOwl:id "UBERON:0000084" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ureteric bud" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003074 ], _:genid111367, _:genid111369 . obo:UBERON_0000085 obo:IAO_0000115 "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." ; obo:UBPROP_0000012 "EHDAA2 has embryo starting later" ; oboInOwl:hasDbXref "BTO:0001508", "EHDAA2:0000005", "FMA:292334", "GAID:1295", "MESH:D009028", "NCIT:C34212", "SCTID:361474003", "UMLS:C0026573", "Wikipedia:Morula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "morula (2-16 cells)" ; oboInOwl:id "UBERON:0000085" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "morula" ; rdfs:subClassOf obo:UBERON_0000922, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000353 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000086 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000107 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000107 ], _:genid111382 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png"^^xsd:anyURI . obo:UBERON_0000086 obo:IAO_0000115 "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." ; obo:UBPROP_0000003 "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "zona pellucida - vitelline membrane" ; oboInOwl:hasDbXref "BTO:0003135", "EHDAA2:0002220", "EHDAA:31", "EHDAA:62", "EMAPA:16035", "FMA:18674", "GAID:410", "MA:0001715", "MESH:D015044", "NCIT:C33896", "TAO:0001111", "UMLS:C0043519", "VHOG:0000720", "Wikipedia:Zona_pellucida", "ZFA:0001111" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oolemma", "pellucid zone", "striated membrane", "vitelline envelope", "vitelline membrane", "zona radiata", "zona striata" ; oboInOwl:id "UBERON:0000086" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "zona pellucida" ; rdfs:subClassOf obo:UBERON_0000476, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_17089 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:CL_0000023 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png"^^xsd:anyURI . obo:UBERON_0000087 obo:IAO_0000115 "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." ; obo:UBPROP_0000001 "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" ; obo:UBPROP_0000003 "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" ; obo:UBPROP_0000011 "This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass]" ; oboInOwl:hasDbXref "EFO:0000547", "EHDAA2:0000830", "EHDAA:40", "EMAPA:16041", "FMA:86557", "NCIT:C13740", "SCTID:361456007", "UMLS:C1283994", "VHOG:0000742", "Wikipedia:Inner_cell_mass" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ICM", "early embryoblast", "embryoblast", "embryoblastus; massa cellularis interna; pluriblastus senior", "pluriblast" ; oboInOwl:id "UBERON:0000087" ; oboInOwl:inSubset core:early_development, core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "inner cell mass" ; rdfs:subClassOf obo:UBERON_0002050, _:genid111404, _:genid111406, _:genid111408, _:genid111410 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg"^^xsd:anyURI . obo:UBERON_0000088 obo:IAO_0000115 "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." ; obo:UBPROP_0000001 "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" ; obo:UBPROP_0000007 "trophoblastic" ; obo:UBPROP_0000011 "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" ; oboInOwl:hasDbXref "BTO:0001079", "CALOHA:TS-1070", "EV:0100120", "FMA:83029", "GAID:1152", "MESH:D014327", "NCIT:C93292", "SCTID:362839005", "UMLS:C0041178", "Wikipedia:Trophoblast" ; oboInOwl:hasExactSynonym "trophoblast layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "massa cellularis externa", "trophoblastus", "trophoderm" ; oboInOwl:id "UBERON:0000088" ; oboInOwl:inSubset core:early_development, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]" ; rdfs:label "trophoblast" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000358 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000351 ], _:genid111420 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg"^^xsd:anyURI . obo:UBERON_0000091 obo:IAO_0000115 "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." ; oboInOwl:hasBroadSynonym "embryonic disc", "embryonic shield", "germinal disc", "germinal disk" ; oboInOwl:hasDbXref "FMA:293863", "NCIT:C34112", "UMLS:C1283997", "Wikipedia:Bilaminar_disc" ; oboInOwl:hasExactSynonym "bilaminary embryonic disc", "bilaminary germ disc" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bilaminar disk" ; oboInOwl:id "UBERON:0000091" ; oboInOwl:inSubset core:early_development, core:pheno_slim ; a owl:Class ; rdfs:label "bilaminar disc" ; rdfs:subClassOf obo:UBERON_0002050, _:genid111431 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png"^^xsd:anyURI . obo:UBERON_0000092 obo:IAO_0000115 "Stage succeeding embryo, including mature structure." ; obo:UBPROP_0000008 "In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)" ; oboInOwl:hasDbXref "BilaDO:0000003", "OGES:000010", "OGES:000014", "OGES:000024", "WBls:0000022", "WBls:0000093", "WBls:0000103" ; oboInOwl:hasExactSynonym "postembryonic stage" ; oboInOwl:hasNarrowSynonym "post-hatching stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "postembryonic" ; oboInOwl:id "UBERON:0000092" ; a owl:Class ; rdfs:label "post-embryonic stage" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/344"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000104 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0009791 ] . obo:UBERON_0000093 obo:IAO_0000115 "A depression or fissure in the surface of an organ." ; dcterms:contributor ; oboInOwl:creation_date "2009-04-09T06:23:22Z" ; oboInOwl:hasDbXref "Wikipedia:Sulcus_(anatomy)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000093" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:label "sulcus" ; rdfs:subClassOf obo:UBERON_0000464 . obo:UBERON_0000094 obo:IAO_0000115 "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." ; dcterms:contributor ; oboInOwl:creation_date "2009-07-30T05:19:13Z" ; oboInOwl:hasBroadSynonym "membrane" ; oboInOwl:hasDbXref "FMA:7145" ; oboInOwl:hasExactSynonym "membrane of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000094" ; a owl:Class ; rdfs:label "membrane organ" ; rdfs:subClassOf obo:UBERON_0000062, _:genid111446 . obo:UBERON_0000095 obo:IAO_0000115 "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." ; obo:UBPROP_0000001 "A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]." ; obo:UBPROP_0000012 "ZFA treats this as a subtype of NC." ; dcterms:contributor ; oboInOwl:creation_date "2009-07-30T07:57:38Z" ; oboInOwl:hasDbXref "TAO:0002173", "Wikipedia:Cardiac_neural_crest", "XAO:0004190", "ZFA:0001648" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac neural crest complex", "complexus cristae neuralis cardiacus" ; oboInOwl:id "UBERON:0000095" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "cardiac neural crest" ; rdfs:subClassOf obo:UBERON_0000479, _:genid111404, _:genid111450 . obo:UBERON_0000102 obo:IAO_0000115 "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." ; oboInOwl:hasDbXref "FMA:73750" ; oboInOwl:hasExactSynonym "lung vascular network", "pulmonary vasculature", "vascular network of lung", "vasculature of lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000102" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lung vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0000104 obo:IAO_0000115 "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FBdv:00000000", "HsapDv:0000001", "MmusDv:0000001", "OGES:000011", "ncithesaurus:Life" ; oboInOwl:hasExactSynonym "entire life cycle", "entire lifespan", "life", "lifespan" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000104" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "life cycle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/532"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000000, _:genid111420, [ a owl:Restriction ; owl:onProperty obo:RO_0002230 ; owl:someValuesFrom obo:UBERON_0000071 ] . obo:UBERON_0000105 obo:IAO_0000115 "A spatiotemporal region encompassing some part of the life cycle of an organism." ; obo:IAO_0000116 "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000012 "the WBls class 'all stages' belongs here as it is the superclass of other WBls stages", "we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage" ; oboInOwl:hasDbXref "BILS:0000105", "EFO:0000399", "FBdv:00007012", "FMA:24120", "HsapDv:0000000", "MESH:D008018", "MmusDv:0000000", "OlatDv:0000010", "PdumDv:0000090", "WBls:0000002", "XAO:1000000", "ZFS:0000000", "ZFS:0100000", "ncithesaurus:Developmental_Stage" ; oboInOwl:hasNarrowSynonym "developmental stage", "stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000105" ; oboInOwl:inSubset core:common_anatomy, core:efo_slim, core:upper_level ; a owl:Class ; rdfs:label "life cycle stage" ; rdfs:subClassOf obo:UBERON_0000000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000104 ] . obo:UBERON_0000106 obo:IAO_0000115 "A stage at which the organism is a single cell produced by means of sexual reproduction." ; obo:UBPROP_0000003 "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" ; oboInOwl:hasDbXref "BILS:0000106", "BilaDO:0000005", "EFO:0001322", "EHDAA:27", "FBdv:00005288", "NCIT:C12601", "PdumDv:0000100", "VHOG:0000745", "Wikipedia:Zygote", "XAO:1000001", "ZFS:0000001" ; oboInOwl:hasExactSynonym "1-cell stage", "fertilized egg stage", "one cell stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fertilized egg stage", "one-cell stage", "zygote", "zygotum" ; oboInOwl:id "UBERON:0000106" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "zygote stage" ; rdfs:seeAlso obo:EMAPA_16033 ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002223 ; owl:someValuesFrom obo:UBERON_0000104 ] . obo:UBERON_0000107 obo:IAO_0000115 "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." ; oboInOwl:hasDbXref "BILS:0000107", "BilaDO:0000006", "EFO:0001290", "FBdv:00000054", "MESH:D002970", "MmusDv:0000004", "OGES:000015", "OGES:000020", "PdumDv:0000200", "Wikipedia:Cleavage_(embryo)", "XAO:1000004", "ZFS:0000046" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000107" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "cleavage stage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002087 ; owl:someValuesFrom obo:UBERON_0000106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000105 [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0040016 ] ) ] . obo:UBERON_0000108 obo:IAO_0000115 "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." ; obo:IAO_0000116 "consider adding a preceding stage 'morula stage' as part of cleavage" ; oboInOwl:hasDbXref "BILS:0000108", "BilaDO:0000007", "EFO:0001282", "HsapDv:0000006", "MmusDv:0000007", "OGES:000003", "OGES:000016", "OGES:000021", "WBls:0000005", "Wikipedia:Blastula", "XAO:1000003", "ZFS:0000045" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000108" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "blastula stage" ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000107 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png"^^xsd:anyURI . obo:UBERON_0000109 obo:IAO_0000115 "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." ; oboInOwl:hasDbXref "BILS:0000109", "BilaDO:0000008", "EFO:0001296", "FBdv:00005317", "HsapDv:0000010", "MmusDv:0000013", "OGES:000004", "OGES:000019", "WBls:0000010", "XAO:1000005", "ZFS:0000047" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blastocystis trilaminaris stage", "trilaminar blastocyst stage", "trilaminar blastoderm stage", "trilaminar disk stage", "trilaminar germ stage", "trilaminar stage" ; oboInOwl:id "UBERON:0000109" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "gastrula stage" ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0007369 ], _:genid111490 . obo:UBERON_0000110 obo:IAO_0000115 "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." ; obo:UBPROP_0000008 "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." ; oboInOwl:hasDbXref "BILS:0000110", "BilaDO:0000009", "HsapDv:0000012", "MmusDv:0000017", "XAO:1000006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000110" ; a owl:Class ; rdfs:label "neurula stage" ; rdfs:seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^xsd:anyURI, "https://github.com/obophenotype/uberon/issues/343"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000109 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0001841 ] . obo:UBERON_0000111 obo:IAO_0000115 "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." ; oboInOwl:hasDbXref "BILS:0000111", "BilaDO:0000010", "HsapDv:0000015", "MmusDv:0000018", "OGES:000005", "OGES:000032", "Wikipedia:Organogenesis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "segmentation stage" ; oboInOwl:id "UBERON:0000111" ; a owl:Class ; rdfs:label "organogenesis stage" ; rdfs:seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^xsd:anyURI, "https://github.com/obophenotype/uberon/issues/533"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002082 ; owl:someValuesFrom obo:GO_0048513 ] . obo:UBERON_0000112 obo:UBPROP_0000001 "The stage of being a sexually immature adult animal[XAO:1000010]." ; obo:UBPROP_0000008 "In mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother)" ; oboInOwl:hasDbXref "BILS:0000112", "BTO:0002168", "EFO:0001300", "EV:0300051", "MmusDv:0000043", "OGES:000009", "XAO:1000010", "XtroDO:0000083", "ZFS:0000051" ; oboInOwl:hasExactSynonym "immature stage" ; oboInOwl:hasNarrowSynonym "juvenile stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subadult stage" ; oboInOwl:id "UBERON:0000112" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "sexually immature stage" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/427"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000066 ] . obo:UBERON_0000113 obo:IAO_0000115 "The stage of being a sexually mature adult animal." ; oboInOwl:hasBroadSynonym "adult stage" ; oboInOwl:hasDbXref "BILS:0000113", "EV:0300064", "EV:0300070", "MIAA:0000403", "MmusDv:0000110", "OGES:000026", "OGES:000027", "XAO:1000093", "ZFS:0000044" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000113" ; a owl:Class ; rdfs:label "post-juvenile adult stage" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/345"^^xsd:anyURI, "https://github.com/obophenotype/uberon/issues/499"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000066 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000112 ] . obo:UBERON_0000114 obo:IAO_0000115 "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." ; obo:UBPROP_0000009 "it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" ; oboInOwl:hasDbXref "EMAPA:35521", "FMA:27533", "MA:0001782", "SCTID:201609008" ; oboInOwl:hasExactSynonym "connective tissue of lung", "pulmonary interstitium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lung interstitial tissue", "lung interstitium", "pulmonary connective tissue", "pulmonary interstitial tissue" ; oboInOwl:id "UBERON:0000114" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lung connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002048 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0004883 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0000115 obo:IAO_0000115 "The epithelial layer of the lung." ; obo:UBPROP_0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" ; oboInOwl:hasDbXref "BTO:0001653", "EMAPA:32860", "MA:0001783" ; oboInOwl:hasExactSynonym "epithelial tissue of lung", "epithelium of lung", "lung epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pulmonary epithelium" ; oboInOwl:id "UBERON:0000115" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lung epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0000117 obo:IAO_0000115 "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." ; obo:UBPROP_0000012 "in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class)" ; oboInOwl:hasDbXref "EMAPA:37946", "FMA:12224" ; oboInOwl:hasExactSynonym "segment of tracheobronchial tree" ; oboInOwl:hasNarrowSynonym "respiratory conducting tube", "segment of tracheobronchial tree", "tracheobronchial tree segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "airway" ; oboInOwl:id "UBERON:0000117" ; a owl:Class ; rdfs:label "respiratory tube" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000483 ] ; owl:equivalentClass _:genid111490 . obo:UBERON_0000118 obo:IAO_0000115 "Structure derived from foregut that becomes a lung[GO]." ; obo:IAO_0000116 "clarify successors - include bronchi?" ; oboInOwl:hasDbXref "BTO:0001643", "EHDAA2:0004089", "NCIT:C34260", "NCIT:C34282", "SCTID:361427007", "UMLS:C1514420", "UMLS:C1514897", "Wikipedia:Respiratory_bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gemma pulmonalis", "gemma respiratoria", "lung bud", "primary lung bud", "respiratory diverticulum" ; oboInOwl:id "UBERON:0000118" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lung bud" ; rdfs:subClassOf obo:UBERON_0005153, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005597 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004872 ], _:genid111551 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png"^^xsd:anyURI . obo:UBERON_0000119 obo:IAO_0000115 "Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium." ; obo:IAO_0000116 "consider adding to caro" ; oboInOwl:hasBroadSynonym "layer" ; oboInOwl:hasDbXref "NCIT:C66831" ; oboInOwl:hasExactSynonym "layer of cells" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cell sheath", "sheath of cells" ; oboInOwl:id "UBERON:0000119" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "cell layer" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002124 ] . obo:UBERON_0000122 obo:IAO_0000115 "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." ; oboInOwl:hasAlternativeId "UBERON:0005163" ; oboInOwl:hasDbXref "CARO:0001001", "FBbt:00005099", "NLX:147821" ; oboInOwl:hasExactSynonym "funiculus", "nerve fiber bundle", "neural fiber bundle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000122" ; a owl:Class ; rdfs:label "neuron projection bundle" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043005 ] . obo:UBERON_0000125 obo:IAO_0000115 "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." ; obo:UBPROP_0000001 "Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]." ; obo:UBPROP_0000012 "Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate." ; oboInOwl:hasBroadSynonym "nucleus" ; oboInOwl:hasDbXref "AEO:0000136", "FMA:83686", "NCIT:C13197", "NLX:28443", "Wikipedia:Nucleus_(neuroanatomy)" ; oboInOwl:hasExactSynonym "nervous system nucleus", "neuraxis nucleus", "neuronal nucleus", "nucleus of CNS" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus of neuraxis" ; oboInOwl:id "UBERON:0000125" ; oboInOwl:inSubset core:cumbo ; a owl:Class ; rdfs:label "neural nucleus" ; rdfs:subClassOf obo:UBERON_0011215, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002020 ], _:genid111569 . obo:UBERON_0000126 obo:IAO_0000115 "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." ; oboInOwl:hasDbXref "EMAPA:37066", "FMA:54501", "NLX:28532", "SCTID:280160003", "Wikipedia:Cranial_nerve_nucleus" ; oboInOwl:hasExactSynonym "cranial neural nucleus", "nucleus of cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus nervi cranialis" ; oboInOwl:id "UBERON:0000126" ; a owl:Class ; rdfs:label "cranial nerve nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001785 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png"^^xsd:anyURI . obo:UBERON_0000127 obo:IAO_0000115 "The group of motor neurons residing in the pons that innervate the muscles of facial expression." ; obo:UBPROP_0000012 "FMA has 3 subclasses - left, right and motor nucleus of facial nerve, but no defs. It's not clear how facial nucleus is distinct from facial motor nucleus." ; oboInOwl:hasDbXref "BAMS:7", "BAMS:7N", "BAMS:VII", "BM:Pons-VII", "DHBA:12420", "EHDAA2:0004638", "EMAPA:35338", "EV:0100267", "FMA:54572", "MA:0001014", "MESH:D065828", "NCIT:C12898", "SCTID:280166009", "UMLS:C0228740", "VHOG:0001412" ; oboInOwl:hasExactSynonym "facial VII nucleus", "facial nerve nucleus", "nucleus of facial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial VII motor nucleus" ; oboInOwl:id "UBERON:0000127" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "facial nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000988 ], _:genid111591 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000126 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001647 ] ) ] . obo:UBERON_0000128 obo:IAO_0000115 "Prominent oval structure in the medulla oblongata, present in pairs, the lower portion of the brainstem. They contain the olivary nuclei." ; oboInOwl:hasDbXref "BTO:0002299", "SCTID:279293003", "Wikipedia:Olivary_body" ; oboInOwl:hasExactSynonym "olive body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oliva", "olivary nucleus", "olive" ; oboInOwl:id "UBERON:0000128" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "olivary body" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray679.png"^^xsd:anyURI . obo:UBERON_0000153 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000153" ; a owl:Class ; rdfs:label "anterior region of body" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0000154 ] ; owl:disjointWith obo:UBERON_0000154 . obo:UBERON_0000154 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000154" ; a owl:Class ; rdfs:label "posterior region of body" ; rdfs:subClassOf obo:UBERON_0000475 . obo:UBERON_0000158 obo:UBPROP_0000001 "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures." ; oboInOwl:hasBroadSynonym "membrane" ; oboInOwl:hasDbXref "FMA:30322", "FMA:82500", "MESH:D008566", "NCIT:C12749" ; oboInOwl:hasExactSynonym "membranous organ component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000158" ; a owl:Class ; rdfs:label "membranous layer" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000064 ] . obo:UBERON_0000159 obo:IAO_0000115 "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." ; obo:IAO_0000116 "requires alignment with EHDAA2 and complete developmental relationships" ; oboInOwl:hasDbXref "BTO:0001978", "CALOHA:TS-2160", "EMAPA:18256", "FMA:15703", "MA:0000330", "MESH:D001003", "NCIT:C12375", "SCTID:245438008", "UMLS:C0227411", "Wikipedia:Anal_canal", "galen:AnalCanal" ; oboInOwl:hasExactSynonym "anal canal", "anal canal viewed anatomically", "anatomical anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anal pad", "anus", "canalis analis", "cloaca", "cloacal chamber", "mesenteron", "pars analis recti" ; oboInOwl:id "UBERON:0000159" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "anal canal" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001052 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001245 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001988 ], _:genid111612 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png"^^xsd:anyURI . obo:UBERON_0000160 obo:IAO_0000115 "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." ; obo:IAO_0000116 "This class is probably too inclusive" ; obo:UBPROP_0000001 "Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]", "The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000007 "intestinal" ; obo:UBPROP_0000008 "In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type." ; oboInOwl:hasDbXref "AAO:0000246", "ANISEED:1235303", "BSA:0000093", "BTO:0000648", "CALOHA:TS-0490", "EFO:0000834", "EMAPA:32874", "EV:0100071", "FMA:7199", "GAID:295", "MA:0000328", "MA:0001524", "MESH:D007422", "MIAA:0000043", "NCIT:C12736", "SCTID:256876008", "TAO:0001338", "UMLS:C0021853", "VHOG:0000056", "WBbt:0005772", "Wikipedia:Intestine", "XAO:0000129", "ZFA:0001338", "galen:Intestine" ; oboInOwl:hasExactSynonym "bowel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal tract" ; oboInOwl:id "UBERON:0000160" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intestine" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ], _:genid111569 . obo:UBERON_0000161 obo:IAO_0000115 "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." ; obo:UBPROP_0000012 "in FMA, this is an anatomical conduit *space*, rather than anatomical conduit" ; oboInOwl:hasBroadSynonym "anatomical ostium", "ostium" ; oboInOwl:hasDbXref "FMA:3724", "SCTID:91837002" ; oboInOwl:hasExactSynonym "anatomical orifice" ; oboInOwl:hasNarrowSynonym "hilum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000161" ; a owl:Class ; rdfs:label "orifice" ; rdfs:subClassOf obo:UBERON_0004111 . obo:UBERON_0000162 obo:IAO_0000115 "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." ; obo:IAO_0000116 "adding df link to embryonic cloaca leads to a cycle in uberon-simple, as cloaca is a suberclass of embryonic cloaca" ; obo:RO_0002175 obo:NCBITaxon_9369 ; obo:UBPROP_0000001 "A common passage for fecal, urinary, and reproductive discharge in most lower vertebrates as well as the terminal end of the hindgut before division into rectum, bladder, and genital primordia in mammalian embryos. [TFD][VHOG]", "Anatomical structure which is the common receptacle for the alimentary canal, Wolffian ducts, oviducts, and the bladder.[AAO]" ; obo:UBPROP_0000003 "A cloaca is apparently a primitive vertebrate feature because it occurs in most primitive gnathostomes and persists in the embryos of almost all vertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "cloacal" ; obo:UBPROP_0000008 "Human beings only have an embryonic cloaca, which is split up into separate tracts during the development of the urinary and reproductive organs" ; obo:UBPROP_0000011 "hindgut endoderm and proctodeal ectoderm." ; oboInOwl:hasDbXref "AAO:0000095", "GAID:1206", "MESH:D002988", "NCIT:C34127", "SCTID:362857006", "SCTID:370631000", "UMLS:C0008987", "VHOG:0001186", "Wikipedia:Cloaca", "XAO:0000244", "ZFA:0005781" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cloacal chamber", "vent" ; oboInOwl:id "UBERON:0000162" ; a owl:Class ; rdfs:label "cloaca" ; rdfs:subClassOf obo:UBERON_0013522, _:genid111630, _:genid111632 . obo:UBERON_0000163 obo:IAO_0000115 "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." ; obo:IAO_0000232 "this class represents the embryonic form of the cloaca, as found in both mammals and non-mammals." ; oboInOwl:hasDbXref "EHDAA2:0000256", "EHDAA:4895", "EMAPA:27573", "Wikipedia:Cloaca_(embryology)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cloaca" ; oboInOwl:id "UBERON:0000163" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "embryonic cloaca" ; rdfs:subClassOf obo:UBERON_0000162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid111591, _:genid111644, _:genid111646 . obo:UBERON_0000164 obo:IAO_0000115 "The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females." ; obo:UBPROP_0000001 "The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG]" ; obo:UBPROP_0000003 "In mammals the lowly monotremes still have a cloaca. Higher types have done away with this structure and have a separate anal outlet for the rectum. The monotreme cloaca shows the initiation of this subdivision. The cloaca has such includes only the distal part, roughly comparable to the proctodeum. The more proximal part is divided into (1) a large dorsal passage into which the intestine opens, the coprodeum, and (2) a ventral portion, the urodeum with which the bladder connects. (...) the development of the placental mammals recapitulates in many respects the phylogenetic story. In the sexually indifferent stage of placental mammal there is a cloaca. While the indifferent stage still persists, a septum develops, and extends out to the closing membrane. This divides the cloaca into two chambers: a coprodeum continuous with the gut above, and a urodeum or urogenital sinus below.[well established][VHOG]" ; obo:UBPROP_0000013 "the term 'urogenital sinus' may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal" ; oboInOwl:hasBroadSynonym "urogenital sinus" ; oboInOwl:hasDbXref "EHDAA2:0004060", "EHDAA:5029", "EHDAA:5919", "EMAPA:17379", "NCIT:C34322", "SCTID:50961009", "UMLS:C0231057", "VHOG:0000414", "Wikipedia:Definitive_urogenital_sinus" ; oboInOwl:hasExactSynonym "UGS", "fetal UGS", "sinus urogenitalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000164" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "primitive urogenital sinus" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000163 ], _:genid111651, _:genid111653 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png"^^xsd:anyURI . obo:UBERON_0000165 obo:IAO_0000115 "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." ; obo:UBPROP_0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" ; obo:UBPROP_0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" ; obo:UBPROP_0000007 "oral" ; obo:UBPROP_0000011 "some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives" ; obo:UBPROP_0000012 "in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips" ; oboInOwl:hasDbXref "AAO:0010355", "BTO:0001090", "BTO:0004698", "CALOHA:TS-1315", "EFO:0000825", "EHDAA2:0001326", "EHDAA:542", "EMAPA:16262", "FBbt:00003126", "FMA:49184", "GAID:75", "MA:0000341", "MA:0002474", "MAT:0000038", "MESH:D009055", "MIAA:0000038", "SCTID:21082005", "TADS:0000040", "TAO:0000547", "TAO:0000590", "TGMA:0000131", "VHOG:0000280", "VHOG:0000812", "Wikipedia:Mouth", "XAO:0003029", "ZFA:0000547", "ZFA:0000590", "galen:Mouth", "http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg" ; oboInOwl:hasExactSynonym "regio oralis" ; oboInOwl:hasNarrowSynonym "adult mouth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavital oralis", "cavitas oris", "cavum oris", "mouth cavity", "oral region", "oral vestibule", "rima oris", "stoma", "stomatodaeum", "trophic apparatus", "vestibule of mouth", "vestibulum oris" ; oboInOwl:id "UBERON:0000165" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mouth" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/661"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0035804 ], _:genid111672 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004921 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg"^^xsd:anyURI . obo:UBERON_0000166 obo:IAO_0000115 "The orifice that connects the mouth to the exterior of the body." ; obo:UBPROP_0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" ; oboInOwl:hasDbXref "FMA:59806" ; oboInOwl:hasExactSynonym "oral fissure", "oral orifice" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mouth", "oral part of face" ; oboInOwl:id "UBERON:0000166" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "oral opening" ; rdfs:subClassOf obo:UBERON_0000161, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] . obo:UBERON_0000167 obo:IAO_0000115 "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." ; obo:UBPROP_0000001 "Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO]", "The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG]" ; obo:UBPROP_0000003 "Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000053", "AAO:0000960", "BSA:0000107", "CALOHA:TS-1315", "EFO:0001975", "EHDAA2:0001324", "EHDAA:6970", "EMAPA:17411", "EMAPA:18399", "EV:0100057", "FMA:20292", "HAO:0000669", "NCIT:C12421", "SCTID:181220002", "TAO:0001027", "TGMA:0000102", "UMLS:C0226896", "VHOG:0000188", "WBbt:0005255", "XAO:0000126", "ZFA:0001027" ; oboInOwl:hasExactSynonym "buccal cavity", "cavity of mouth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bucca" ; oboInOwl:id "UBERON:0000167" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "oral cavity" ; rdfs:subClassOf obo:UBERON_0002553, _:genid111644, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000165 ] ) ] . obo:UBERON_0000168 obo:IAO_0000115 "A section dividing a colon along a proximal-distal axis." ; oboInOwl:hasDbXref "FMA:222905" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "segment of colon" ; oboInOwl:id "UBERON:0000168" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "proximal-distal subdivision of colon" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid111653 ] . obo:UBERON_0000170 obo:IAO_0000115 "The pair of anatomical structures comprised of a left lung and right lung." ; oboInOwl:hasDbXref "FMA:68877" ; oboInOwl:hasExactSynonym "lungs", "lungs pair", "pulmones", "set of lungs" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000170" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pair of lungs" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0002167 ; owl:onProperty obo:RO_0002351 ; owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ], [ a owl:Restriction ; owl:onClass obo:UBERON_0002168 ; owl:onProperty obo:RO_0002351 ; owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ], _:genid111724 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034925 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0002167 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0000171 obo:IAO_0000115 "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." ; oboInOwl:hasDbXref "EMAPA:17607", "SCTID:272626006", "SPD:0000428", "TGMA:0001247" ; oboInOwl:hasExactSynonym "apparatus respiratorius organ", "breathing organ", "organ of apparatus respiratorius", "organ of respiratory system", "respiratory organ", "respiratory system organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gas exchange organ" ; oboInOwl:id "UBERON:0000171" ; oboInOwl:inSubset core:functional_classification, core:organ_slim ; a owl:Class ; rdfs:label "respiration organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ; owl:equivalentClass _:genid111672 . obo:UBERON_0000173 obo:IAO_0000115 "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." ; oboInOwl:hasDbXref "BTO:0000068", "CALOHA:TS-0034", "EMAPA:36771", "ENVO:02000021", "EV:0100123", "FMA:305905", "GAID:1155", "MA:0002893", "MESH:D000653", "NCIT:C13188", "UMLS:C0002638", "VHOG:0001267" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acqua amnii", "liquor amnii" ; oboInOwl:id "UBERON:0000173" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "amniotic fluid" ; rdfs:subClassOf obo:UBERON_0000463, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000305 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002328 ; owl:someValuesFrom obo:GO_0001701 ] . obo:UBERON_0000174 obo:IAO_0000115 "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." ; oboInOwl:hasAlternativeId "UBERON:0000324", "UBERON:0007550" ; oboInOwl:hasDbXref "AEO:0000184", "BTO:0000491", "EHDAA2_RETIRED:0003184", "ENVO:02000022", "FMA:9674", "galen:Excretion" ; oboInOwl:hasExactSynonym "excreted substance", "portion of excreted substance", "waste substance" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "excretion" ; oboInOwl:id "UBERON:0000174" ; a owl:Class ; rdfs:label "excreta" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0007588 ] ) ] . obo:UBERON_0000178 obo:IAO_0000115 "A fluid that is composed of blood plasma and erythrocytes." ; obo:IAO_0000232 "This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid." ; obo:UBPROP_0000001 "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]", "Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" ; obo:UBPROP_0000003 "Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000046", "BTO:0000089", "CALOHA:TS-0079", "EFO:0000296", "EHDAA2:0000176", "EHDAA:418", "EMAPA:16332", "ENVO:02000027", "EV:0100047", "FMA:9670", "GAID:965", "MA:0000059", "MESH:D001769", "MIAA:0000315", "NCIT:C12434", "TAO:0000007", "UMLS:C0005767", "VHOG:0000224", "Wikipedia:Blood", "XAO:0000124", "ZFA:0000007", "galen:Blood" ; oboInOwl:hasExactSynonym "portion of blood", "vertebrate blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "whole blood" ; oboInOwl:id "UBERON:0000178" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "blood" ; rdfs:subClassOf obo:UBERON_0000179, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002390 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001969 ], _:genid111757, _:genid111760, _:genid111762 . obo:UBERON_0000179 obo:IAO_0000115 "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." ; dcterms:contributor ; oboInOwl:creation_date "2009-04-08T04:38:19Z" ; oboInOwl:hasDbXref "CARO:0000081" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blood or blood analog", "circulating fluid" ; oboInOwl:id "UBERON:0000179" ; a owl:Class ; rdfs:label "haemolymphatic fluid" ; rdfs:subClassOf obo:UBERON_0006314 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002193 ] ) ] . obo:UBERON_0000199 obo:IAO_0000115 "The narrow part of the shaft of the radius just below the head." ; oboInOwl:hasDbXref "FMA:23479", "SCTID:181942005", "galen:NeckOfRadius" ; oboInOwl:hasExactSynonym "collum radii", "radial neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000199" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neck of radius" ; rdfs:subClassOf _:genid111780 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0000200 obo:IAO_0000115 "A ridge on the cerebral cortex. It is generally surrounded by one or more sulci ." ; obo:UBPROP_0000202 obo:FMA_72015 ; oboInOwl:hasDbXref "BTO:0002495", "FMA:83874", "NCIT:C32290", "SCTID:279165009", "UMLS:C0458308", "Wikipedia:Gyrus", "neuronames:1211" ; oboInOwl:hasExactSynonym "cerebral gyrus", "gyrus of neuraxis", "neuraxis gyrus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "folia", "folium", "folium of brain", "gyri", "gyri of cerebrum", "gyrus of cerebral hemisphere", "gyrus of cerebrum" ; oboInOwl:id "UBERON:0000200" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gyrus" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/573"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0034768, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ], _:genid111724 . obo:UBERON_0000203 obo:IAO_0000115 "Dorsal part (roof region) of the telencephalon[GO]." ; obo:UBPROP_0000003 "In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume." ; obo:UBPROP_0000008 "In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus" ; dcterms:contributor ; oboInOwl:creation_date "2009-04-18T12:03:09Z" ; oboInOwl:hasAlternativeId "UBERON:0007333" ; oboInOwl:hasDbXref "BTO:0003399", "DMBA:15903", "EFO:0003534", "SCTID:369224000", "TAO:0000505", "TAO:0007007", "Wikipedia:Avian_pallium", "Wikipedia:Pallium_(neuroanatomy)", "ZFA:0000505", "neuronames:3240" ; oboInOwl:hasExactSynonym "area dorsalis telencephali", "dorsal part of telencephalon", "dorsal telencephalic area", "dorsal telencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000203" ; oboInOwl:inSubset core:developmental_classification, core:efo_slim ; a owl:Class ; rdfs:label "pallium" ; rdfs:seeAlso "https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/87"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] . obo:UBERON_0000204 obo:IAO_0000115 "Ventral part (base region) of the telencephalon." ; obo:UBPROP_0000012 "BTO term refers specifically to the avian structure" ; dcterms:contributor ; oboInOwl:creation_date "2009-04-18T12:12:27Z" ; oboInOwl:hasDbXref "BTO:0003401", "DMBA:15751", "EFO:0003522", "TAO:0000304", "ZFA:0000304" ; oboInOwl:hasExactSynonym "area ventralis telencephali", "subpallium", "ventral telencephalon" ; oboInOwl:hasNarrowSynonym "subpallium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000204" ; oboInOwl:inSubset core:developmental_classification, core:efo_slim ; a owl:Class ; rdfs:label "ventral part of telencephalon" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ], _:genid111808 . obo:UBERON_0000209 obo:IAO_0000115 "The bone forming the forehead and roof of the eye orbit." ; obo:UBPROP_0000008 "fused in humans, paired in other animals" ; obo:UBPROP_0000011 "In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993)." ; oboInOwl:hasDbXref "AAO:0000206", "EMAPA:19016", "FMA:52734", "GAID:226", "MA:0001466", "MESH:D005624", "NCIT:C32635", "SCTID:181793006", "UMLS:C0016732", "VHOG:0001324", "VSAO:0000208", "Wikipedia:Frontal_bone" ; oboInOwl:hasNarrowSynonym "frontal", "frontal bone", "os frontal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os frontale" ; oboInOwl:id "UBERON:0000209" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "tetrapod frontal bone" ; rdfs:subClassOf obo:UBERON_0002514, obo:UBERON_0010428, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001697 ], _:genid111818 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png"^^xsd:anyURI . obo:UBERON_0000210 obo:IAO_0000115 "In humans: bone forming side and roof of cranium. Each bone is irregularly quadrilateral in form, and has two surfaces, four borders, and four angles." ; obo:UBPROP_0000003 "The homologization of cranial bones of actinopterygians with those of sarcopterygians based on the bone names established in human anatomy is favored in order to permit the building of phylogenetic relationship schemes beyond the taxonomic boundaries of osteichthyans (including tetrapods). (...) In actinopterygians, the terms parietal and postparietal bones have to replace the commonly used terms 'frontal' and 'parietal' bones for the two paired bones on the skull roof.[well established][VHOG]" ; obo:UBPROP_0000008 "The frontal bone in teleost fish is the homolog of the parietal bone in tetrapods[various]. In many non-mammalian tetrapods, they are bordered to the rear by a pair of postparietal bones that may be solely in the roof of the skull, or slope downwards to contribute to the back of the skull, depending on the species. In the living tuatara, and many fossil species, a small opening, the parietal foramen, lies between the two parietal bones. This opening is the location of a third eye in the midline of the skull, which is much smaller than the two main eyes" ; oboInOwl:hasDbXref "AAO:0000390", "EMAPA:18715", "FMA:9613", "GAID:229", "MA:0001469", "MESH:D010294", "NCIT:C12766", "SCTID:181794000", "UMLS:C0030558", "VHOG:0001324", "VHOG:0001326", "Wikipedia:Parietal_bone" ; oboInOwl:hasNarrowSynonym "actinopterygian frontal bone", "frontal bone", "parietal", "parietal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os parietale" ; oboInOwl:id "UBERON:0000210" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "tetrapod parietal bone" ; rdfs:subClassOf obo:UBERON_0002514, obo:UBERON_0010428, _:genid111762, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004339 ], _:genid111829 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/21/Gray132.png"^^xsd:anyURI . obo:UBERON_0000211 obo:IAO_0000115 "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." ; obo:UBPROP_0000001 "Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496].", "Portion of connective tissue that connects bone or cartilage.[TAO]" ; obo:UBPROP_0000003 "Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]" ; obo:UBPROP_0000012 "this groups both skeletal and non-skeletal ligaments. What is called a 'ligament' in many AOs is actually a skeletal ligament" ; oboInOwl:hasDbXref "CALOHA:TS-2145", "EFO:0001966", "EMAPA:35493", "FMA:21496", "FMA:30319", "MA:0000113", "MESH:D008022", "NCIT:C13046", "SCTID:182358004", "TAO:0001682", "UMLS:C0023685", "VHOG:0001272", "Wikipedia:Ligament", "XAO:0004031", "ZFA:0001675", "galen:Ligament" ; oboInOwl:hasExactSynonym "ligament organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000211" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ligament" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg"^^xsd:anyURI . obo:UBERON_0000218 obo:IAO_0000115 "A neural arch that is part of a vertebral bone 2." ; oboInOwl:hasDbXref "FMA:24053" ; oboInOwl:hasExactSynonym "vertebral foramen of cervical vertebra 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000218" ; a owl:Class ; rdfs:label "vertebral arch of axis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001093 ] ) ] . obo:UBERON_0000219 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "FMA:24293", "SCTID:281228008", "Wikipedia:Atlas_(anatomy)#Vertebral_foramen" ; oboInOwl:hasExactSynonym "vertebral foramen of cervical vertebra 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000219" ; a owl:Class ; rdfs:label "vertebral foramen of atlas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001092 ] ) ] . obo:UBERON_0000220 obo:IAO_0000115 "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." ; oboInOwl:hasDbXref "FMA:24939", "MESH:D001269", "NCIT:C32158", "SCTID:361831006", "UMLS:C0004169", "Wikipedia:Atlanto-occipital_joint", "ncithesaurus:Atlanto-occipital_Joint-Atlanto" ; oboInOwl:hasExactSynonym "articulatio atlanto-occipitalis", "atlanto occipital joint", "atlantooccipital joint", "craniovertebral joint", "occipito atlantal joint", "occipito-atlantal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio atlantooccipitalis" ; oboInOwl:id "UBERON:0000220" ; a owl:Class ; rdfs:label "atlanto-occipital joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011138 ], _:genid111865 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001676 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png"^^xsd:anyURI . obo:UBERON_0000303 obo:IAO_0000115 "An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized]." ; obo:UBPROP_0000001 "Originates on the iliac portion of the ventral iliac rim and inserts on the lateral surface of the M. adductor magnus.[AAO]" ; obo:UBPROP_0000012 "definition generalized to accommodate AAO class - 'Originates on the iliac portion of the ventral iliac rim and inserts on the lateral surface of the M. adductor magnus.' [AAO:0010034]" ; oboInOwl:hasDbXref "AAO:0010034", "BTO:0000029", "EMAPA:36220", "FMA:22441", "SCTID:181686003", "Wikipedia:Adductor_longus_muscle" ; oboInOwl:hasExactSynonym "adductor longus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "long adductor muscle", "musculus adductor longus" ; oboInOwl:id "UBERON:0000303" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "adductor longus" ; rdfs:subClassOf obo:UBERON_0011144, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ], _:genid111874, _:genid111876 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e2/Anterior_Hip_Muscles_2.PNG"^^xsd:anyURI . obo:UBERON_0000304 obo:IAO_0000115 "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." ; obo:IAO_0000116 "TODO - add layer relations. 'tendon sheath' GAT in FMA." ; oboInOwl:hasDbXref "BTO:0000051", "FMA:45087", "FMA:76715", "NCIT:C96299", "SCTID:361885006", "UMLS:C0224856", "Wikipedia:Tendon_sheath" ; oboInOwl:hasExactSynonym "synovial tendon sheath" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vagina tendinis" ; oboInOwl:id "UBERON:0000304" ; a owl:Class ; rdfs:label "tendon sheath" ; rdfs:subClassOf _:genid111818, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0011234 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000043 ] ) ] . obo:UBERON_0000305 obo:IAO_0000115 "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." ; obo:UBPROP_0000001 "A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG]" ; obo:UBPROP_0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" ; obo:UBPROP_0000007 "amniotic" ; oboInOwl:hasDbXref "BTO:0000065", "CALOHA:TS-0033", "EHDAA2:0000116", "EHDAA:136", "EMAPA:16109", "EV:0100122", "FMA:80223", "GAID:1298", "MESH:D000650", "NCIT:C12365", "SCTID:181457005", "UMLS:C0002630", "VHOG:0000721", "Wikipedia:Amnion" ; oboInOwl:hasExactSynonym "amnios" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000305" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "amnion" ; rdfs:subClassOf obo:UBERON_0005631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003254 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid111895, _:genid111898, _:genid111900 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png"^^xsd:anyURI . obo:UBERON_0000307 obo:IAO_0000115 "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." ; obo:IAO_0000116 "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" ; oboInOwl:hasAlternativeId "UBERON:0007011" ; oboInOwl:hasDbXref "BILA:0000059", "BTO:0000128", "GAID:1294", "MESH:D036703", "OGEM:000006", "Wikipedia:Blastula" ; oboInOwl:hasExactSynonym "blastula embryo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blastosphere" ; oboInOwl:id "UBERON:0000307" ; oboInOwl:inSubset core:inconsistent_with_fma ; a owl:Class ; rdfs:label "blastula" ; rdfs:subClassOf obo:UBERON_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000108 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png"^^xsd:anyURI . obo:UBERON_0000309 obo:IAO_0000115 "The external portion of an animal body derived from ectoderm and mesoderm layers that encloses the body cavity." ; obo:UBPROP_0000008 "defined generically to encompass both vertebrates and invertebrates" ; obo:UBPROP_0000012 "the BTO class refers to earthworms." ; oboInOwl:hasDbXref "BTO:0000139", "EMAPA:32761", "FMA:10427", "SCTID:281483004", "galen:BodyWall" ; oboInOwl:hasExactSynonym "wall fo trunk" ; oboInOwl:hasNarrowSynonym "trunk wall", "wall of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000309" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "body wall" ; rdfs:subClassOf obo:UBERON_0000475 . obo:UBERON_0000310 obo:IAO_0000115 "The upper ventral region of the torso of an organism." ; obo:UBPROP_0000008 "The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's." ; oboInOwl:hasDbXref "BTO:0000149", "CALOHA:TS-2083", "EV:0100124", "FMA:9601", "GAID:33", "MESH:D001940", "NCIT:C12971", "SCTID:181131000", "UMLS:C0006141", "Wikipedia:Breast", "galen:Breast" ; oboInOwl:hasExactSynonym "mammary part of chest", "mammary region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mamma" ; oboInOwl:id "UBERON:0000310" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "breast" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Closeup_of_female_breast.jpg"^^xsd:anyURI . obo:UBERON_0000311 obo:IAO_0000115 "A skeletal muscle whose contraction extends or stretches a body part." ; oboInOwl:hasDbXref "BTO:0000151", "FMA:75000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extensor" ; oboInOwl:id "UBERON:0000311" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Any of the muscles that increase the angle between segments of a limb, E.g. straightening the elbow or knee or bending the wrist or spine backward. The movement is usually directed backward, with the notable exception of the knee joint. In humans, certain muscles of the hand and foot are named for this function. In the hand these include the extensor carpi radialis brevis, extensor carpi radialis longus, and extensor carpi ulnaris, which run from the humerus along the back of the forearm to the metacarpal bones at the back of the hand. [http://www.britannica.com/EBchecked/topic/198909/extensor-muscle]" ; rdfs:label "extensor muscle" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010962 ] . obo:UBERON_0000313 obo:IAO_0000115 "Cartilage pertaining to the tibia." ; obo:IAO_0000232 "This class represents a portion of cartilage tissue located in the tibia, *not* the cartilaginous condensation of an emrbyonic tibia" ; oboInOwl:hasDbXref "BTO:0000207", "FMA:33923" ; oboInOwl:hasExactSynonym "tibial cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilage of tibia" ; oboInOwl:id "UBERON:0000313" ; a owl:Class ; rdfs:label "portion of cartilage tissue in tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0000315 obo:IAO_0000115 "The space between the arachnoid and pia mater." ; oboInOwl:hasDbXref "BTO:0000230", "EMAPA:32666", "FMA:83716", "GAID:689", "MESH:D013346", "SCTID:362311001", "Wikipedia:Subarachnoid_space" ; oboInOwl:hasExactSynonym "subarachnoid space of CNS", "subarachnoid space of central nervous system", "subarachnoid space of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas subarachnoidea", "cavum subarachnoideale", "spatium leptomeningeum", "spatium subarachnoideum", "subarachnoid cavity" ; oboInOwl:id "UBERON:0000315" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "subarachnoid space" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010743 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001019 ; owl:someValuesFrom obo:UBERON_0001359 ], _:genid111944 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid111865 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray769-en.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray769.png"^^xsd:anyURI . obo:UBERON_0000316 obo:IAO_0000115 "A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus." ; oboInOwl:hasDbXref "BTO:0000242", "FMA:83689", "MESH:D002582", "Wikipedia:Mucus#Reproductive_system" ; oboInOwl:hasExactSynonym "cervix mucus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000316" ; a owl:Class ; rdfs:label "cervical mucus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0000317 obo:IAO_0000115 "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." ; oboInOwl:hasAlternativeId "UBERON:0003347", "UBERON:0004981" ; oboInOwl:hasDbXref "BTO:0000271", "CALOHA:TS-0164", "EFO:0003038", "EMAPA:27375", "FMA:14984", "FMA:85388", "MA:0003194", "SCTID:362157008" ; oboInOwl:hasExactSynonym "colon mucosa", "colon mucous membrane", "colonic mucosa", "colonic mucous membrane", "large bowel mucosa", "mucosa of colon", "mucosa of large bowel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000317" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "colonic mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0000320 obo:IAO_0000115 "A mucosa that is part of a duodenum [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003348" ; oboInOwl:hasDbXref "BTO:0000367", "CALOHA:TS-0213", "EMAPA:27235", "FMA:14942", "MA:0003207", "SCTID:362146003" ; oboInOwl:hasExactSynonym "doudenal mucosa", "duodenal mucous membrane", "mucosa of duodenum", "mucous membrane of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "duodenum mucosa" ; oboInOwl:id "UBERON:0000320" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodenal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid111898 ] . obo:UBERON_0000323 obo:IAO_0000115 "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." ; obo:IAO_0000116 "TODO - check fetus/embryo. WP: An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus." ; obo:UBPROP_0000001 "Fetal structure, which is a developmental form of a vertebrate animal at any given time point from 8 weeks of gestation to birth (or hatching). Examples: There is only one fetus[FMA:63919]." ; oboInOwl:hasDbXref "BTO:0000449", "CALOHA:TS-0360", "EFO:0001323", "FBbt:00005333", "FMA:63919", "GAID:552", "MESH:D005333", "NCIT:C13235", "SCTID:83418008", "UMLS:C0015965" ; oboInOwl:hasNarrowSynonym "fetus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryo late growth stage", "embryo late stage" ; oboInOwl:id "UBERON:0000323" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "late embryo" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000922 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0007220 ] ) ] . obo:UBERON_0000325 obo:IAO_0000115 "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." ; oboInOwl:hasDbXref "BTO:0000503", "EMAPA:27181", "FMA:14919" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000325" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "gastric gland" ; rdfs:subClassOf obo:UBERON_0002365, _:genid111991 . obo:UBERON_0000326 obo:IAO_0000115 "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." ; oboInOwl:hasDbXref "BTO:0000504", "CALOHA:TS-2235", "FMA:62973", "GAID:1166", "MESH:D010189" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreatic fluid", "pancreatic secretion", "succus pancreaticus" ; oboInOwl:id "UBERON:0000326" ; a owl:Class ; rdfs:label "pancreatic juice" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0000328 obo:IAO_0000115 "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." ; obo:IAO_0000232 "We model the digestive tract as consisting of two parts: the wall and the lumen." ; oboInOwl:hasDbXref "BTO:0000547", "FMA:45653" ; oboInOwl:hasExactSynonym "digestive tract wall", "wall of digestive tract", "wall of gut" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "wall of alimentary tract" ; oboInOwl:id "UBERON:0000328" ; a owl:Class ; rdfs:label "gut wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0000331 obo:IAO_0000115 "A mucosa that is part of a ileum [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0000619", "CALOHA:TS-0470", "EMAPA:35424", "FMA:14956", "MA:0003216", "SCTID:85458007" ; oboInOwl:hasExactSynonym "ileal mucous membrane", "ileum mucosa", "ileum mucosa of organ", "ileum mucous membrane", "ileum organ mucosa", "mucosa of ileum", "mucosa of organ of ileum", "mucous membrane of ileum", "organ mucosa of ileum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000331" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ileal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0000332 obo:IAO_0000115 "Bone marrow in which the fat cells predominate in the meshes of the reticular network." ; oboInOwl:hasDbXref "BTO:0000635", "FMA:74596", "SCTID:328639002", "SCTID:5023006" ; oboInOwl:hasExactSynonym "medulla ossium flava", "yellow marrow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fat marrow" ; oboInOwl:id "UBERON:0000332" ; a owl:Class ; rdfs:label "yellow bone marrow" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007195 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002371 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000136 ] ) ] . obo:UBERON_0000333 obo:IAO_0000115 "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." ; obo:UBPROP_0000012 "Note that some sources treat 'intestinal gland' as synonymous with crypts" ; oboInOwl:hasDbXref "BTO:0000640", "FMA:15052", "SCTID:266297002" ; oboInOwl:hasExactSynonym "bowel mucosa gland", "bowel mucosa of organ gland", "bowel mucous membrane gland", "bowel organ mucosa gland", "gland of bowel mucosa", "gland of bowel mucosa of organ", "gland of bowel mucous membrane", "gland of bowel organ mucosa", "gland of intestinal mucosa", "gland of intestine mucosa", "gland of intestine mucosa of organ", "gland of intestine mucous membrane", "gland of intestine organ mucosa", "gland of mucosa of bowel", "gland of mucosa of intestine", "gland of mucosa of organ of bowel", "gland of mucosa of organ of intestine", "gland of mucous membrane of bowel", "gland of mucous membrane of intestine", "gland of organ mucosa of bowel", "gland of organ mucosa of intestine", "glandula intestinalis", "intestinal mucosa gland", "intestine mucosa gland", "intestine mucosa of organ gland", "intestine mucous membrane gland", "intestine organ mucosa gland", "mucosa of bowel gland", "mucosa of intestine gland", "mucosa of organ of bowel gland", "mucosa of organ of intestine gland", "mucous membrane of bowel gland", "mucous membrane of intestine gland", "organ mucosa of bowel gland", "organ mucosa of intestine gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandulae intestinales" ; oboInOwl:id "UBERON:0000333" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "intestinal gland" ; rdfs:subClassOf obo:UBERON_0002530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ] ) ] . obo:UBERON_0000344 obo:IAO_0000115 "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." ; obo:RO_0002171 obo:UBERON_0000009 ; obo:UBPROP_0000007 "mucosal" ; obo:UBPROP_0000012 "FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately" ; oboInOwl:hasDbXref "AEO:0000199", "BTO:0000886", "CALOHA:TS-2031", "EHDAA2_RETIRED:0003234", "EV:0100382", "FMA:85355", "FMA:85358", "GAID:297", "MESH:D009092", "NCIT:C13166", "SCTID:361693009", "UMLS:C0026724", "Wikipedia:Mucous_membrane", "galen:Mucosa" ; oboInOwl:hasExactSynonym "mucosa of organ", "mucosa of organ part", "mucosal region", "mucous membrane", "organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "region of mucosa", "tunica mucosa" ; oboInOwl:id "UBERON:0000344" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mucosa" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000483 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png"^^xsd:anyURI . obo:UBERON_0000345 obo:IAO_0000115 "A dielectric (electrically insulating) material consisting of protein and fat that forms a layer, the myelin sheath, usually around only the axon of a neuron. Myelin is about 40 % water; the dry mass of myelin is about 70 - 85 % lipids and about 15 - 30 % proteins. Some of the proteins that make up myelin are myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The primary lipid of myelin is a glycolipid called galactocerebroside (GalC). The intertwining hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath." ; obo:IAO_0000116 "cede to other ontology. Retired in ncit" ; obo:RO_0002175 obo:NCBITaxon_6681 ; oboInOwl:hasDbXref "BTO:0000894", "FMA:62977", "Wikipedia:Myelin", "ncithesaurus:Myelin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000345" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "myelin" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0000347 obo:IAO_0000115 "The insulating envelope that surrounds nerve fibers or axons." ; obo:IAO_0000116 "do not cede to GO until GO includes has_part link to myelin" ; oboInOwl:hasDbXref "BTO:0000900", "CALOHA:TS-2363", "FMA:62983", "GAID:731", "GO:0043209", "MESH:D009186", "NCIT:C13261", "UMLS:C0026973" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medullary sheath" ; oboInOwl:id "UBERON:0000347" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "entire myelin sheath" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000345 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0043209 ] . obo:UBERON_0000348 obo:IAO_0000115 "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead." ; obo:UBPROP_0000001 "Sensory medial ramus of the trigeminal nerve.[AAO]" ; obo:UBPROP_0000003 "The profundus nerve is a distinct nerve only in fishes. (...) In mammals, the profundus nerve is the same as the most rostral (ophthalmic) branch of the trigeminal nerve.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010648", "BTO:0000926", "EHDAA2:0002088", "EHDAA:3744", "EMAPA:17800", "FMA:52621", "GAID:837", "MA:0001104", "MESH:D009882", "NCIT:C33215", "SCTID:280210000", "UMLS:C0029082", "VHOG:0001349", "Wikipedia:Ophthalmic_nerve" ; oboInOwl:hasExactSynonym "cranial nerve V, branch V1", "first branch of fifth cranial nerve", "first division of fifth cranial nerve", "first division of trigeminal nerve", "nervus ophthalmicus (V1)", "nervus ophthalmicus (Va)", "nervus ophthalmicus [v1]", "nervus ophthalmicus [va]", "ophthalmic division [V1]", "ophthalmic division [Va]", "ophthalmic division of fifth cranial nerve", "ophthalmic division of trigeminal nerve (V1)", "ophthalmic division of trigeminal nerve (Va)", "ophthalmic nerve [V1]", "ophthalmic nerve [Va]", "opthalmic nerve", "ramus opthalmicus profundus (ramus V1)", "rostral branch of trigeminal nerve", "trigeminal V nerve ophthalmic division" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ciliary nerve", "ethmoidal nerve", "ophthalmic division", "profundal nerve", "profundus", "profundus nerve", "trigeminal nerve ophthalmic division" ; oboInOwl:id "UBERON:0000348" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "Terminology notes. This nerve is known by a ridiculous number of names[http://palaeos.com/vertebrates/glossary/glossaryPo.html]" ; rdfs:label "ophthalmic nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_1000021 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0035597 ], _:genid112092 . obo:UBERON_0000349 obo:IAO_0000115 "A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]." ; obo:IAO_0000116 "obsoletion proposes. The current part_of children were chosen as the intersection of what is stated in wikipedia and in the FMA. NIF: We are including Limbic System because it is still used by neuroscientists and others, but as a data annotation term, it is very poor because it is not a clearly defined entity." ; oboInOwl:hasDbXref "BTO:0000928", "CALOHA:TS-1307", "FMA:242000", "GAID:615", "MESH:D008032", "NCIT:C94541", "SCTID:361342009", "UMLS:C0023715", "Wikipedia:Limbic_system", "neuronames:2055" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "visceral brain" ; oboInOwl:id "UBERON:0000349" ; oboInOwl:inSubset core:non_informative, core:pheno_slim ; a owl:Class ; rdfs:comment "includes the hippocampus, amygdala, anterior thalamic nuclei, and limbic cortex, which support a variety of functions including emotion, behavior, long term memory, and olfaction [Wikipedia]" ; rdfs:label "limbic system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg"^^xsd:anyURI . obo:UBERON_0000351 obo:IAO_0000115 "A fibrous membrane, which, in the neck, represents the supraspinal ligaments of the upper vertebrae." ; obo:RO_0002161 obo:NCBITaxon_9596 ; obo:RO_0002175 obo:NCBITaxon_9608, obo:NCBITaxon_9895 ; obo:UBPROP_0000008 "In humans it is a tendon-like structure that has developed independently in humans and other animals well adapted for running. In some four legged animals, particularly ungulates, the nuchal ligament serves to sustain the weight of the head" ; obo:UBPROP_0000009 "As it is required for running, not all animals have a nuchal ligament" ; oboInOwl:hasDbXref "BTO:0000952", "EMAPA:19207", "FMA:13427", "SCTID:166962007", "Wikipedia:Nuchal_ligament" ; oboInOwl:hasExactSynonym "ligament of neck", "ligamentum nuchae" ; oboInOwl:hasNarrowSynonym "paddywhack" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "paxwax" ; oboInOwl:id "UBERON:0000351" ; a owl:Class ; rdfs:label "nuchal ligament" ; rdfs:subClassOf obo:UBERON_0008846, [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001676 ], _:genid112128, _:genid112131 . obo:UBERON_0000353 obo:IAO_0000115 "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." ; obo:UBPROP_0000007 "parenchymal" ; obo:UBPROP_0000011 "Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin" ; obo:UBPROP_0000012 "the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated" ; oboInOwl:hasDbXref "EHDAA:3015", "EHDAA:3905", "EHDAA:3999", "EHDAA:4005", "EHDAA:6899", "EHDAA:6903", "EHDAA:6994", "EHDAA:8086", "EHDAA:9182", "EHDAA:9190", "EHDAA:9196", "EHDAA:9202", "FMA:45732", "NCIT:C74601", "UMLS:C0933845", "Wikipedia:Parenchyma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000353" ; a owl:Class ; rdfs:label "parenchyma" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032501 ] ; owl:disjointWith obo:UBERON_0003891 . obo:UBERON_0000355 obo:IAO_0000115 "A mucosa that is part of a pharynx [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003344" ; oboInOwl:hasDbXref "BTO:0001047", "EMAPA:26957", "FMA:55031", "MA:0003143", "SCTID:362121003" ; oboInOwl:hasExactSynonym "mucosa of organ of pharynx", "mucosa of pharynx", "mucous membrane of pharynx", "organ mucosa of pharynx", "pharynx mucosa", "pharynx mucosa of organ", "pharynx mucous membrane", "pharynx organ mucosa", "tunica mucosa pharyngea", "tunica mucosa pharyngis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mucous membrane of the pharynx" ; oboInOwl:id "UBERON:0000355" ; a owl:Class ; rdfs:label "pharyngeal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0000358 obo:IAO_0000115 "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." ; obo:IAO_0000116 "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" ; oboInOwl:hasDbXref "BTO:0001099", "CALOHA:TS-0076", "EFO:0000295", "EMAPA:36035", "EV:0100394", "FMA:83041", "GAID:1153", "MESH:D001755", "NCIT:C13739", "SCTID:308837009", "UMLS:C1281743", "Wikipedia:Blastocyst" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blastocystis", "blastula" ; oboInOwl:id "UBERON:0000358" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "blastocyst" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000307 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000087 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000088 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000085 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000108 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg"^^xsd:anyURI . obo:UBERON_0000361 obo:IAO_0000115 "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." ; oboInOwl:hasDbXref "BTO:0001160", "FMA:74595", "SCTID:328538003", "SCTID:75330005" ; oboInOwl:hasExactSynonym "medulla ossium rubra", "parenchymal red marrow", "red marrow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parenchyma of none marrow marrow" ; oboInOwl:id "UBERON:0000361" ; a owl:Class ; rdfs:label "red bone marrow" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012429 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002371 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000988 ] ) ] . obo:UBERON_0000362 obo:IAO_0000115 "The inner portion of the kidney consisting of the renal pyramids." ; obo:UBPROP_0000010 "The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the arcuate arterioles. The arcuate arterioles each in turn branch into interlobular arterioles, which finally reach the glomeruli. At the glomerulus the blood reaches a highly disfavourable pressure gradient and a large exchange surface area, which forces the serum portion of the blood out of the vessel into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, and finally leaves the kidney by means of the collecting duct, leading to the renal ureter. The renal medulla contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. The renal medulla is hypertonic to the filtrate in the nephron and aids in the reabsorption of water" ; oboInOwl:hasDbXref "BTO:0001167", "CALOHA:TS-1157", "EMAPA:19279", "GAID:425", "MA:0000373", "MESH:D007679", "NCIT:C12740", "SCTID:30737000", "UMLS:C0022664", "Wikipedia:Renal_medulla", "galen:MedullaOfKidney" ; oboInOwl:hasExactSynonym "kidney medulla", "medulla of kidney", "medulla renalis", "pyramides renales", "renal medullae", "renal medullae set", "renal pyramids", "renal pyramids set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medullary pyramids", "renal marrow" ; oboInOwl:id "UBERON:0000362" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "Note that 'renal medulla' is not synonymous with 'medullary region of kidney'. The former is composed of kidney pyramids only, while the latter covers kidney pyramids and renal columns, which are histologically different." ; rdfs:label "renal medulla" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004200 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0070295 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg"^^xsd:anyURI . obo:UBERON_0000366 obo:IAO_0000115 "A skeletal muscle whose contraction bends a joint." ; obo:UBPROP_0000001 "A muscle that decreases the angle of a joint.[TAO]" ; oboInOwl:hasDbXref "BTO:0001257", "FMA:74559", "FMA:74999", "TAO:0005271", "ZFA:0005271" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "flexor" ; oboInOwl:id "UBERON:0000366" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "flexor muscle" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010977 ] . obo:UBERON_0000369 obo:IAO_0000115 "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." ; obo:UBPROP_0000003 "Thus, certain telencephalic characters - such as the presence of a pallium divided into lateral, dorsal, and medial formations and a subpallium divided into striatum and septum - appear to characterize all vertebrates. They are primitive characters and are homologous among all vertebrates.[well established][VHOG]" ; obo:UBPROP_0000013 "The term has been used in a few different ways: * It is a pair of nuclear masses which form the basal ganglia, along with the subthalamic nucleus and the substantia nigra. * It may also refer to both the basal ganglia and internal capsule collectively.[2]" ; oboInOwl:hasAlternativeId "UBERON:0010082" ; oboInOwl:hasDbXref "BAMS:CSTR", "BTO:0001311", "CALOHA:TS-0183", "EFO:0000381", "EHDAA2:0000596", "EMAPA:17549", "EV:0100184", "FMA:77616", "GAID:667", "MESH:D003342", "NCIT:C12448", "SCTID:279318005", "UMLS:C0010097", "VHOG:0001175", "Wikipedia:Corpus_striatum", "neuronames:2339" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "striate body", "striated body" ; oboInOwl:id "UBERON:0000369" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "* According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (also known as the lenticular nucleus) and the caudate nucleus * According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum" ; rdfs:label "corpus striatum" ; rdfs:subClassOf obo:UBERON_0002616, _:genid112199 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray656.png"^^xsd:anyURI . obo:UBERON_0000375 obo:IAO_0000115 "The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini." ; oboInOwl:hasDbXref "AAO:0010688", "AAO:0010703", "BTO:0001375", "EHDAA2:0002086", "EMAPA:17798", "FMA:52996", "GAID:834", "MA:0001101", "MESH:D008340", "NCIT:C32779", "SCTID:280212008", "UMLS:C0024695", "VHOG:0001345", "Wikipedia:Mandibular_nerve" ; oboInOwl:hasExactSynonym "inferior maxillary nerve", "mandibular division [V3]", "mandibular division [Vc]", "mandibular division of fifth cranial nerve", "mandibular division of trigeminal nerve [Vc; V3]", "mandibular nerve [V3]", "mandibular nerve [Vc]", "nervus mandibularis [Vc; V3]", "nervus mandibularis [v3]", "nervus mandibularis [vc]", "ramus mandibularis (ramus V3)", "third division of fifth cranial nerve", "third division of trigeminal nerve", "trigeminal V nerve mandibular division" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "n. mandibularis", "nervus mandibularis", "trigeminal nerve mandibular division" ; oboInOwl:id "UBERON:0000375" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mandibular nerve" ; rdfs:subClassOf obo:UBERON_0001021, _:genid112128 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png"^^xsd:anyURI . obo:UBERON_0000376 obo:IAO_0000115 "The part of the hindlimb between pelvis and the knee, corresponding to the femur." ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group." ; oboInOwl:hasDbXref "BTO:0001376", "CALOHA:TS-2039", "EFO:0001943", "EHDAA2:0002130", "EHDAA:5171", "EHDAA:6200", "EMAPA:17499", "FMA:24967", "GAID:50", "MA:0000052", "MESH:D013848", "NCIT:C33763", "SCTID:302544002", "UMLS:C0039866", "VHOG:0000349", "Wikipedia:Thigh", "galen:Thigh" ; oboInOwl:hasExactSynonym "hind limb stylopod", "hind limb stylopodium", "hind propodium", "hindlimb propodium", "hindlimb stylopod", "hindlimb stylopodium", "proximal segment of free lower limb", "stylopod of hind limb", "stylopod of hindlimb", "stylopod of lower limb", "thigh", "upper leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "femur" ; oboInOwl:id "UBERON:0000376" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "hindlimb stylopod" ; rdfs:subClassOf obo:UBERON_0002472, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0015052 ], _:genid112230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002472 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4b/Gray1238.png"^^xsd:anyURI . obo:UBERON_0000377 obo:IAO_0000115 "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." ; obo:UBPROP_0000001 "Medial ramus (sensory) of the trigeminal nerve.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" ; oboInOwl:hasDbXref "AAO:0010670", "BTO:0001378", "EHDAA2:0002087", "EMAPA:17799", "FMA:52724", "GAID:836", "MA:0001103", "MESH:D008442", "SCTID:280211001", "VHOG:0001346", "Wikipedia:Maxillary_nerve" ; oboInOwl:hasExactSynonym "maxillary division [V2]", "maxillary division [Vb]", "maxillary division of fifth cranial nerve", "maxillary division of trigeminal nerve (Vb; V2)", "maxillary nerve [V2]", "maxillary nerve [Vb]", "nervus maxillaris (Vb; V2)", "nervus maxillaris [v2]", "nervus maxillaris [vb]", "ramus maxillaris (ramus V2)", "second division of fifth cranial nerve", "second division of trigeminal nerve", "trigeminal V nerve maxillary division" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "n. maxillaris", "nervus maxillaris", "trigeminal nerve maxillary division" ; oboInOwl:id "UBERON:0000377" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "maxillary nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001645 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png"^^xsd:anyURI . obo:UBERON_0000378 obo:IAO_0000115 "The muscular portion of the tongue." ; obo:UBPROP_0000003 "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001386", "EHDAA2:0002065", "EHDAA:9146", "EMAPA:17883", "FMA:46689", "MA:0001596", "NCIT:C49301", "NCIT:C52707", "SCTID:244781004", "UMLS:C0448325", "UMLS:C1710437", "VHOG:0001390", "Wikipedia:Muscles_of_tongue" ; oboInOwl:hasExactSynonym "muscle of tongue", "muscle organ of tongue", "skeletal muscle tissue of tongue", "tongue skeletal muscle", "tongue skeletal muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculi linguae" ; oboInOwl:id "UBERON:0000378" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tongue muscle" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001723 ], _:genid112278 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002177 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001575 obo:UBERON_0001576 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Gray1019.png"^^xsd:anyURI . obo:UBERON_0000379 obo:IAO_0000115 "A mucosa that is part of a respiratory airway." ; oboInOwl:hasDbXref "BTO:0001390", "FMA:7471", "SCTID:660006" ; oboInOwl:hasExactSynonym "mucosa of organ of trachea", "mucosa of organ of windpipe", "mucosa of trachea", "mucosa of windpipe", "mucous membrane of trachea", "mucous membrane of windpipe", "organ mucosa of trachea", "organ mucosa of windpipe", "trachea mucosa", "trachea mucosa of organ", "trachea mucous membrane", "trachea organ mucosa", "tracheal mucous membrane", "tunica mucosa (tracheae)", "tunica mucosa tracheae", "windpipe mucosa", "windpipe mucosa of organ", "windpipe mucous membrane", "windpipe organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000379" ; a owl:Class ; rdfs:label "tracheal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001005 ] ) ] . obo:UBERON_0000382 obo:IAO_0000115 "Apocrine sweat glands are sweat glands composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. The ducts of apocrine glands open into the canals of hair follicles. The stimulus for the secretion of apocrine sweat glands is adrenaline, which is a hormone carried in the blood[WP]." ; obo:RO_0002161 obo:NCBITaxon_9822 ; obo:UBPROP_0000008 "In humans, apocrine sweat glands are found only in certain locations of the body: the axillae (armpits), the areola of the nipples, and the genitoanal region." ; oboInOwl:hasDbXref "BTO:0001458", "EMAPA:37426", "FMA:59155", "MESH:D001050", "NCIT:C32132", "SCTID:399916008", "UMLS:C0930083", "Wikipedia:Apocrine_sweat_gland" ; oboInOwl:hasExactSynonym "glandula sudorifera apocrina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000382" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "apocrine sweat gland" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/2111" ; rdfs:subClassOf obo:UBERON_0001820, obo:UBERON_0008974, _:genid112316 ; owl:disjointWith obo:UBERON_0000423 . obo:UBERON_0000383 obo:IAO_0000115 "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." ; obo:IAO_0000116 "consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77" ; obo:RO_0002161 obo:NCBITaxon_6040 ; obo:UBPROP_0000001 "Anatomical system that consists of the muscles of the body.[VSAO]" ; obo:UBPROP_0000012 "we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA" ; oboInOwl:hasDbXref "AAO:0000307", "BILA:0000088", "BTO:0001369", "BTO:0001485", "EFO:0000801", "EMAPA:35578", "FMA:72954", "MA:0002888", "MAT:0000025", "MIAA:0000025", "VSAO:0000033", "XAO:0004042" ; oboInOwl:hasExactSynonym "muscle system", "muscle system of body", "muscular system", "musculature system", "set of all muscles", "set of muscles of body", "vertebrate muscular system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muskelsystem" ; oboInOwl:id "UBERON:0000383" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "musculature of body" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003012 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011216 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001015 ] ) ] . obo:UBERON_0000388 obo:IAO_0000115 "A part of the pharynx that consists of a flap of elastic cartilage tissue plus a mucous membrane covering, attached to the entrance of the larynx. The epiglottis is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink[MP,modified]." ; obo:UBPROP_0000007 "epiglottal" ; oboInOwl:hasDbXref "BTO:0001628", "EHDAA2:0004081", "EMAPA:18289", "FMA:55130", "GAID:111", "MESH:D004825", "NCIT:C12709", "SCTID:245502004", "UMLS:C0014540", "Wikipedia:Epiglottis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000388" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiglottis" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002180 ; owl:someValuesFrom obo:UBERON_0001742 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002180 ; owl:someValuesFrom obo:UBERON_0004982 ], _:genid112340 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e2/Gray958.png"^^xsd:anyURI . obo:UBERON_0000389 obo:IAO_0000115 "Tissue that surrounds the lens nucleus." ; oboInOwl:hasDbXref "BTO:0001632", "CALOHA:TS-0542", "FMA:58970", "MESH:D007904", "SCTID:280626006" ; oboInOwl:hasExactSynonym "cortex of lens" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000389" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lens cortex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005614 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000390 ] ) ] . obo:UBERON_0000390 obo:IAO_0000115 "The core of the crystalline lens, surrounded by the cortex." ; oboInOwl:hasDbXref "BTO:0001633", "FMA:58971", "MESH:D007907", "SCTID:280628007" ; oboInOwl:hasExactSynonym "nucleus of lens" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000390" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lens nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005614 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000389 ] ) ] . obo:UBERON_0000391 obo:IAO_0000115 "Pia mater or arachnoid mater." ; obo:IAO_0000116 "check relationship to secondary meninx" ; obo:UBPROP_0000012 "in FMA/NIF this is a superclass of PM/AM - in BTO it is the mereological sum. We go with superclass here, as we are naming the class in the singular" ; oboInOwl:hasDbXref "BTO:0001634", "CALOHA:TS-0546", "FMA:231515", "NCIT:C32979", "NLXANAT:090207", "SCTID:362303006", "UMLS:C0228126", "Wikipedia:Leptomeninges", "neuronames:2347" ; oboInOwl:hasExactSynonym "leptomeninges" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arachnoid mater and pia mater", "arachnoidea mater et pia mater", "pia-arachnoid", "pia-arachnoid of neuraxis" ; oboInOwl:id "UBERON:0000391" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "leptomeninx" ; rdfs:subClassOf obo:UBERON_0002360, _:genid112278 . obo:UBERON_0000395 obo:IAO_0000115 "The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus." ; obo:IAO_0000116 "in BTO this is part of the cochlear modiolus, but this leads to the CG being in both the nervous and skeletal systems" ; oboInOwl:hasDbXref "BAMS:GcVIII", "BTO:0001688", "EHDAA2:0002198", "EMAPA:17572", "FMA:53445", "GAID:722", "MA:0001085", "MESH:D013136", "SCTID:368955007", "VHOG:0001183", "Wikipedia:Spiral_ganglion", "neuronames:1405" ; oboInOwl:hasExactSynonym "Corti's ganglion", "cochlear part of vestibulocochlear ganglion", "ganglion of Corti", "spiral ganglion", "vestibulocochlear VIII ganglion cochlear component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglion cochlearis", "ganglion spirale", "ganglion spirale cochleae", "spiral ganglion of cochlea", "vestibulocochlear ganglion cochlear component" ; oboInOwl:id "UBERON:0000395" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cochlear ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002827 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016490 ], _:genid112375 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0004727 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray903.png"^^xsd:anyURI . obo:UBERON_0000397 obo:IAO_0000115 "An epithelium that is part of a colon [Automatically generated definition]." ; obo:UBPROP_0000001 "Intestinal epithelium which lines the lumen of the posterior intestine.[TAO]" ; oboInOwl:hasDbXref "BTO:0001709", "CALOHA:TS-0163", "EMAPA:18941", "FMA:17302", "MA:0003195", "SCTID:42978003", "TAO:0005128", "ZFA:0005128" ; oboInOwl:hasExactSynonym "colon epithelial tissue", "colon epithelium", "epithelial tissue of colon", "epithelial tissue of large bowel", "epithelium of colon", "epithelium of large bowel", "large bowel epithelial tissue", "large bowel epithelium", "posterior intestine epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000397" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "colonic epithelium" ; rdfs:subClassOf obo:UBERON_0000483 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0000398 obo:IAO_0000115 "Any portion of cartilage tissue that is part of the sternum." ; oboInOwl:hasDbXref "FMA:32567" ; oboInOwl:hasExactSynonym "cartilage of sternum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000398" ; a owl:Class ; rdfs:comment "Examples: cartilage of manubrium, cartilage of xiphoid process" ; rdfs:label "cartilage tissue of sternum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] . obo:UBERON_0000399 obo:IAO_0000115 "A mucosa that is part of a jejunum [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001742", "CALOHA:TS-0495", "EMAPA:27109", "FMA:14949", "MA:0003214", "SCTID:362151009" ; oboInOwl:hasExactSynonym "jejunal mucous membrane", "jejunum mucosa", "jejunum mucosa of organ", "jejunum mucous membrane", "jejunum organ mucosa", "mucosa of jejunum", "mucosa of organ of jejunum", "mucous membrane of jejunum", "organ mucosa of jejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000399" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0000400 obo:IAO_0000115 "An epithelium that is part of a jejunum." ; oboInOwl:hasDbXref "BTO:0001743", "CALOHA:TS-0494", "EMAPA:18668", "FMA:17232", "MA:0003215", "SCTID:57300004" ; oboInOwl:hasExactSynonym "epithelium of jejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000400" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal epithelium" ; rdfs:subClassOf obo:UBERON_0001902, _:genid112428 ; owl:equivalentClass _:genid112340 . obo:UBERON_0000401 obo:IAO_0000115 "The upturned perpendicular extremity of the mandible." ; oboInOwl:hasDbXref "BTO:0001751", "EMAPA:25100", "FMA:52828", "MA:0002815", "SCTID:361739000", "Wikipedia:Ramus_of_the_mandible" ; oboInOwl:hasExactSynonym "mandible ramus", "ramus of mandible" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower ramus", "rami mandibulae", "ramus mandibulae" ; oboInOwl:id "UBERON:0000401" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mandibular ramus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001684 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png"^^xsd:anyURI . obo:UBERON_0000402 obo:IAO_0000115 "The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0001761", "CALOHA:TS-0660", "FMA:59644", "SCTID:278940000", "Wikipedia:Nasal_vestibule" ; oboInOwl:hasExactSynonym "vestibular part of nasal cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vestibulum nasale", "vestibulum nasi" ; oboInOwl:id "UBERON:0000402" ; a owl:Class ; rdfs:label "nasal vestibule" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001707 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray994.png"^^xsd:anyURI . obo:UBERON_0000403 obo:IAO_0000115 "The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL)." ; oboInOwl:hasDbXref "BTO:0001809", "CALOHA:TS-0896", "EMAPA:37949", "FMA:46494", "GAID:80", "MESH:D012535", "NCIT:C89807", "SCTID:181480002", "UMLS:C0036270", "Wikipedia:Scalp", "galen:Scalp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "scalpus" ; oboInOwl:id "UBERON:0000403" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "scalp" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000014 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0006661 ], _:genid112444 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Layers_of_the_scalp_and_meninges.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/e/eb/Double_cowlick.jpg"^^xsd:anyURI . obo:UBERON_0000409 obo:IAO_0000115 "A gland in which the principal secretory cells are serous secreting cells." ; obo:UBPROP_0000001 "glands that secrete watery albuminous material that often contains enzymes[MP:0008052]." ; oboInOwl:hasDbXref "BTO:0001837", "EMAPA:37950", "FMA:62889", "Wikipedia:Serous_gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000409" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "serous gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0013232 ], _:genid112375 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000313 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png"^^xsd:anyURI . obo:UBERON_0000410 obo:IAO_0000115 "A mucosa that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001846", "FMA:62652", "SCTID:30802009" ; oboInOwl:hasExactSynonym "bronchi mucosa", "bronchi mucosa of organ", "bronchi mucous membrane", "bronchi organ mucosa", "bronchial trunk mucosa", "bronchial trunk mucosa of organ", "bronchial trunk mucous membrane", "bronchial trunk organ mucosa", "bronchus mucosa", "bronchus mucosa of organ", "bronchus mucous membrane", "bronchus organ mucosa", "mucosa of bronchi", "mucosa of bronchial trunk", "mucosa of bronchus", "mucosa of organ of bronchi", "mucosa of organ of bronchial trunk", "mucosa of organ of bronchus", "mucous membrane of bronchi", "mucous membrane of bronchial trunk", "mucous membrane of bronchus", "organ mucosa of bronchi", "organ mucosa of bronchial trunk", "organ mucosa of bronchus", "tunica mucosa bronchi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000410" ; a owl:Class ; rdfs:label "bronchial mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0000414 obo:IAO_0000115 "A gland in which the principal secretory cells are mucus secreting cells." ; obo:UBPROP_0000008 "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" ; oboInOwl:hasDbXref "AAO:0010601", "BTO:0001979", "EMAPA:37913", "FMA:62888", "Wikipedia:Mucous_gland" ; oboInOwl:hasExactSynonym "glandula mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muciparous gland", "mucous secreting gland", "mucus gland", "mucus-secreting gland" ; oboInOwl:id "UBERON:0000414" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "mucous gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070254 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0000912 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000319 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png"^^xsd:anyURI . obo:UBERON_0000415 obo:IAO_0000115 "An anatomical wall that is part of an artery [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0002009", "FMA:14155", "galen:ArterialWall" ; oboInOwl:hasExactSynonym "arterial wall", "wall of artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000415" ; a owl:Class ; rdfs:label "artery wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0000423 obo:IAO_0000115 "A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion." ; obo:UBPROP_0000008 "in mice, found only on footpads; in humans, entire body including soles and palms" ; oboInOwl:hasDbXref "BTO:0002323", "FMA:59154", "GAID:945", "MA:0003039", "MESH:D004439", "NCIT:C32490", "SCTID:361699008", "UMLS:C0013492", "Wikipedia:Eccrine_sweat_gland" ; oboInOwl:hasExactSynonym "glandula sudorifera eccrina", "glandula sudorifera merocrina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eccrine gland", "merocrine sweat gland" ; oboInOwl:id "UBERON:0000423" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "eccrine sweat gland" ; rdfs:subClassOf obo:UBERON_0001820, obo:UBERON_0010243, _:genid112514 . obo:UBERON_0000428 obo:IAO_0000115 "The prostate epithelium." ; obo:IAO_0000116 "TODO - check 2 FMA IDs" ; oboInOwl:hasAlternativeId "UBERON:0002452" ; oboInOwl:hasDbXref "BTO:0002397", "CALOHA:TS-2065", "EMAPA:35711", "FMA:66812", "FMA:79643", "MA:0001737", "NCIT:C13103", "UMLS:C1179826" ; oboInOwl:hasExactSynonym "epithelial tissue of prostate", "epithelial tissue of prostate gland", "epithelium of prostate", "epithelium of prostate gland", "epithelium of prostatic gland", "prostate epithelial tissue", "prostate gland epithelial tissue", "prostate gland epithelium", "prostatic epithelium", "prostatic gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000428" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "prostate epithelium" ; rdfs:subClassOf obo:UBERON_0000485, obo:UBERON_0005911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0000429 obo:IAO_0000115 "A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies." ; oboInOwl:hasAlternativeId "UBERON:0012372" ; oboInOwl:hasDbXref "BTO:0002437", "EMAPA:35446", "FMA:77597", "MA:0001147" ; oboInOwl:hasExactSynonym "enteric nerve plexus", "intrinsic nerve plexus", "plexus entericus", "plexus nervosus entericus", "sympathetic enteric nerve plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000429" ; a owl:Class ; rdfs:label "enteric plexus" ; rdfs:subClassOf obo:UBERON_0001816 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001810 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:UBERON_0000439 obo:IAO_0000115 "The arachnoid trabeculae are delicate strands of connective tissue that loosely connect the two innermost layers of the meninges -- the arachnoid mater and the pia mater. They are found within the subarachnoid space where cerebrospinal fluid is also found. Embryologically, the trabeculae are the remnants of the common precursor that forms both the arachnoid and pial layers of the meninges." ; oboInOwl:hasDbXref "BTO:0002500", "FMA:83979", "Wikipedia:Arachnoid_trabeculae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arachnoid trabeculae", "trabecula arachnoideum" ; oboInOwl:id "UBERON:0000439" ; a owl:Class ; rdfs:label "arachnoid trabecula" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005581 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002362 ] ) ] . obo:UBERON_0000440 obo:IAO_0000115 "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." ; obo:UBPROP_0000007 "trabecular" ; oboInOwl:hasDbXref "BTO:0002501", "FMA:85273", "Wikipedia:Trabecula" ; oboInOwl:hasExactSynonym "trabeculae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000440" ; oboInOwl:inSubset core:grouping_class, core:pheno_slim ; a owl:Class ; rdfs:label "trabecula" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001873 ] . obo:UBERON_0000442 obo:IAO_0000115 "A vein that drains the left pampiniform plexus and empties into the left renal vein." ; oboInOwl:hasDbXref "BTO:0002679", "EMAPA:37383", "FMA:14341", "MA:0002220", "NCIT:C52697", "SCTID:53500001" ; oboInOwl:hasExactSynonym "right spermatic vein", "vena testicularis (adrenalis) dextra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena testicularis dextra", "vena testicularis sinistra" ; oboInOwl:id "UBERON:0000442" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right testicular vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001142 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001144 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0004534 ] ) ] . obo:UBERON_0000443 obo:IAO_0000115 "A vein that drains the right pampiniform plexus and empties into the inferior vena cava." ; oboInOwl:hasDbXref "BTO:0002680", "EMAPA:37167", "FMA:14345", "MA:0002219", "NCIT:C52696", "SCTID:90988008" ; oboInOwl:hasExactSynonym "left spermatic vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena testicularis dextra", "vena testicularis sinistra" ; oboInOwl:id "UBERON:0000443" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left testicular vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001142 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001144 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0004533 ] ) ] . obo:UBERON_0000444 obo:IAO_0000115 "." ; obo:IAO_0000116 "introducing part_of to 'cortex of lymph node' as in issue 7 introduces equivalencies; the part_of has instead been added to 'lymph node follicle'" ; oboInOwl:hasDbXref "BTO:0002684", "FMA:55222", "NCIT:C33040", "SCTID:64626006", "UMLS:C0229654" ; oboInOwl:hasExactSynonym "nodular lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "folliculus lymphaticus", "lymphatic follicle", "lymphatic nodule", "lymphoid nodule", "nodulus lymphaticus", "nodulus lymphoideus" ; oboInOwl:id "UBERON:0000444" ; a owl:Class ; rdfs:label "lymphoid follicle" ; rdfs:subClassOf obo:UBERON_0001744 . obo:UBERON_0000446 obo:IAO_0000115 "Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996)." ; obo:UBPROP_0000001 "Subdivision of the telencephalon on the midline between the lateral ventricles which contains the septum pellucidum and the septal nuclei[FMA][FMA:61842]." ; oboInOwl:hasBroadSynonym "Se", "septum" ; oboInOwl:hasDbXref "BAMS:SA", "BAMS:SEP", "BAMS:Sep", "BAMS:Spt", "BIRNLEX:963", "BM:Tel-Spt", "BTO:0002705", "EMAPA:32837", "FMA:61842", "MA:0000924", "UMLS:C0752060", "neuronames:255" ; oboInOwl:hasExactSynonym "area septalis", "septal area", "septum (NN)", "telencephalon septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "massa praecommissuralis", "septal region", "septum pellucidum (BNA,PNA)", "septum telencephali" ; oboInOwl:id "UBERON:0000446" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "septum of telencephalon" ; rdfs:subClassOf obo:UBERON_0002020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] . obo:UBERON_0000454 obo:IAO_0000115 "The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain." ; oboInOwl:hasDbXref "BTO:0002858", "FMA:242188", "NCIT:C98712", "UMLS:C0815008" ; oboInOwl:hasExactSynonym "cerebral medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subcortex" ; oboInOwl:id "UBERON:0000454" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebral subcortex" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:UBERON_0000456 obo:IAO_0000115 "A portion of organism substance that is produced by exocrine glands." ; obo:UBPROP_0000012 "BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions" ; oboInOwl:hasAlternativeId "UBERON:0006540" ; oboInOwl:hasBroadSynonym "secretion" ; oboInOwl:hasDbXref "AEO:0001005", "BTO:0002977", "BTO:0002979", "EMAPA:36535", "FMA:9675", "MA:0002504", "MESH:D012634", "NCIT:C34062", "UMLS:C1516992", "galen:Secretion" ; oboInOwl:hasExactSynonym "bodily secretion", "exocrine gland fluid/secretion", "secreted substance" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "exocrine gland fluid", "exocrine gland fluid or secretion", "exocrine gland secretion", "external secretion" ; oboInOwl:id "UBERON:0000456" ; a owl:Class ; rdfs:label "secretion of exocrine gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002365 ] ) ] . obo:UBERON_0000457 obo:IAO_0000115 "Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses." ; oboInOwl:hasDbXref "BTO:0002996", "FMA:70527" ; oboInOwl:hasExactSynonym "cavernous branch of cavernous part of internal carotid artery", "ramus sinus cavernosi (pars cavernosa) (arteria carotis interna)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000457" ; a owl:Class ; rdfs:label "cavernous artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001675 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001532 ] ) ] . obo:UBERON_0000458 obo:IAO_0000115 "The region of the opening of the uterine cervix into the uterine cavity." ; oboInOwl:hasDbXref "BTO:0003002", "FMA:86485", "NCIT:C12309", "SCTID:264460007", "UMLS:C0227837" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000458" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endocervix" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000064 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0000459 obo:IAO_0000115 "An anatomical wall that is part of a uterus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0003083", "FMA:17560", "SCTID:245485002" ; oboInOwl:hasExactSynonym "anatomical wall of uterus", "uterus anatomical wall", "uterus wall", "wall of uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000459" ; a owl:Class ; rdfs:label "uterine wall" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:UBERON_0000463 obo:IAO_0000115 "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010839", "AEO:0000004", "BILA:0000004", "CALOHA:TS-2101", "CARO:0000004", "EHDAA2:0003004", "EMAPA:35178", "FBbt:00007019", "FMA:9669", "HAO:0000004", "MA:0002450", "NCIT:C13236", "SPD:0000008", "TAO:0001487", "TGMA:0001824", "VHOG:0001726", "XAO:0004001", "ZFA:0001487", "galen:BodySubstance" ; oboInOwl:hasExactSynonym "body fluid or substance", "body substance", "organism substance", "portion of body substance", "portion of organism substance" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000463" ; oboInOwl:inSubset core:common_anatomy, core:pheno_slim, core:upper_level ; a owl:Class ; rdfs:label "organism substance" ; rdfs:subClassOf obo:UBERON_0000465, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002198 ], _:genid112647 . obo:UBERON_0000464 obo:IAO_0000115 "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasBroadSynonym "lumen", "space" ; oboInOwl:hasDbXref "AAO:0010110", "AEO:0000005", "BILA:0000005", "CARO:0000005", "EHDAA2:0003005", "FBbt:00007017", "FMA:5897", "HAO:0000005", "NCIT:C94478", "TAO:0001668", "TGMA:0001825", "UMLS:C0524461", "VHOG:0001728", "XAO:0003190", "ZFA:0001643" ; oboInOwl:hasExactSynonym "lumen space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomical spaces" ; oboInOwl:id "UBERON:0000464" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical space" ; rdfs:subClassOf obo:UBERON_0000466, [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000061 ] ; owl:disjointWith obo:UBERON_0006800 . obo:UBERON_0000465 obo:IAO_0000115 "Anatomical entity that has mass." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010264", "AEO:0000006", "BILA:0000006", "CARO:0000006", "EHDAA2:0003006", "FBbt:00007016", "FMA:67165", "HAO:0000006", "TAO:0001836", "TGMA:0001826", "VHOG:0001721" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000465" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "material anatomical entity" ; rdfs:subClassOf obo:BFO_0000040, obo:UBERON_0001062 ; owl:disjointWith obo:UBERON_0000466 . obo:UBERON_0000466 obo:IAO_0000115 "Anatomical entity that has no mass." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010265", "AEO:0000007", "BILA:0000007", "CARO:0000007", "EHDAA2:0003007", "FBbt:00007015", "FMA:67112", "HAO:0000007", "TAO:0001835", "TGMA:0001827", "VHOG:0001727" ; oboInOwl:hasExactSynonym "immaterial physical anatomical entity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000466" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "immaterial anatomical entity" ; rdfs:subClassOf obo:BFO_0000141, obo:UBERON_0001062 . obo:UBERON_0000467 obo:IAO_0000115 "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasBroadSynonym "system" ; oboInOwl:hasDbXref "AAO:0000007", "AEO:0000011", "BILA:0000011", "BIRNLEX:14", "BSA:0000049", "CALOHA:TS-2088", "CARO:0000011", "EHDAA2:0003011", "EHDAA:392", "EMAPA:16103", "EV:0100000", "FBbt:00004856", "FMA:7149", "HAO:0000011", "MA:0000003", "NCIT:C12919", "SCTID:278195005", "TAO:0001439", "TGMA:0001831", "UMLS:C0460002", "VHOG:0001725", "WBbt:0005746", "WBbt:0005763", "Wikipedia:Organ_system", "XAO:0003002", "ZFA:0001439", "galen:AnatomicalSystem" ; oboInOwl:hasExactSynonym "body system", "connected anatomical system", "organ system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomical systems" ; oboInOwl:id "UBERON:0000467" ; oboInOwl:inSubset core:common_anatomy, core:pheno_slim, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "anatomical system" ; rdfs:seeAlso obo:EHDAA2_0001330 ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000062 ] . obo:UBERON_0000468 obo:IAO_0000115 "Anatomical structure that is an individual member of a species and consists of more than one cell." ; obo:IAO_0000116 "TODO - split body and mc organism? body continues after death stage" ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000007 "organismal" ; oboInOwl:hasBroadSynonym "organism" ; oboInOwl:hasDbXref "AAO:0010026", "AEO:0000191", "BILA:0000012", "BIRNLEX:18", "BSA:0000038", "BTO:0000042", "CARO:0000012", "EFO:0002906", "EHDAA2:0003103", "EHDAA2:0003191", "EHDAA:1", "EMAPA:25765", "EV:0100016", "FBbt:00000001", "FMA:256135", "HAO:0000012", "NCIT:C13041", "SCTID:243928005", "TADS:0000001", "TAO:0001094", "TGMA:0001832", "VHOG:0000671", "WBbt:0007833", "Wikipedia:Multi-cellular_organism", "XAO:0003004", "ZFA:0001094", "galen:Organism", "ncithesaurus:Whole_Organism" ; oboInOwl:hasExactSynonym "multi-cellular organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Koerper", "body", "whole body", "whole organism" ; oboInOwl:id "UBERON:0000468" ; oboInOwl:inSubset core:common_anatomy, core:efo_slim, core:pheno_slim, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "multicellular organism" ; rdfs:subClassOf obo:UBERON_0010000 . obo:UBERON_0000471 obo:IAO_0000115 "Multi-tissue structure that is part of a compound organ." ; obo:IAO_0000232 "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" ; oboInOwl:hasDbXref "AAO:0010017", "AEO:0000019", "BILA:0000019", "CARO:0000019", "EHDAA2:0003019", "HAO:0000019", "TAO:0001489", "TGMA:0001835", "XAO:0003039", "ZFA:0001489" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "compound organ components" ; oboInOwl:id "UBERON:0000471" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "compound organ component" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003103 ] . obo:UBERON_0000473 obo:IAO_0000115 "A gonad of a male animal. A gonad produces and releases sperm." ; obo:UBPROP_0000001 "Male reproductive organ.[TAO]" ; obo:UBPROP_0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" ; obo:UBPROP_0000007 "testicular" ; obo:UBPROP_0000008 "The testes are descended in metatherian and eutherian mammals, first transabdominally, then inguinoscrotally" ; oboInOwl:hasAlternativeId "UBERON:0002117" ; oboInOwl:hasDbXref "AAO:0000606", "BILA:0000124", "BSA:0000085", "BTO:0001363", "CALOHA:TS-1030", "EFO:0000984", "EHDAA2:0002007", "EHDAA:8146", "EMAPA:17972", "EV:0100102", "FBbt:00004928", "FMA:7210", "GAID:396", "HAO:0001007", "MA:0000411", "MAT:0000132", "MESH:D013737", "MIAA:0000132", "NCIT:C12412", "SCTID:181431007", "TAO:0000598", "UMLS:C0039597", "VHOG:0000252", "WBbt:0006794", "Wikipedia:Testis", "XAO:0000157", "ZFA:0000598", "galen:Testis" ; oboInOwl:hasExactSynonym "gonad of male genitalia", "gonad of male reproductive system", "male gonad", "testicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "orchis", "testes", "testiculus" ; oboInOwl:id "UBERON:0000473" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "testis" ; rdfs:subClassOf obo:UBERON_0000991, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009117 ] ; owl:disjointWith obo:UBERON_0000992, obo:UBERON_0009117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png"^^xsd:anyURI . obo:UBERON_0000474 obo:IAO_0000115 "The organs and associated structures associated with bearing offspring in a female animal." ; obo:UBPROP_0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0000083", "CALOHA:TS-1303", "EFO:0000969", "EHDAA2:0000506", "EHDAA:8116", "EMAPA:17959", "EV:0100110", "FBbt:00004864", "FMA:45663", "GAID:364", "HAO:0000324", "MA:0000381", "MESH:D005836", "MIAA:0000028", "NCIT:C12402", "SCTID:361386004", "TGMA:0000635", "UMLS:C0700038", "VHOG:0000726", "Wikipedia:Female_genitalia", "WikipediaCategory:Female_reproductive_system", "XAO:0000156" ; oboInOwl:hasExactSynonym "female organism genitalia", "female organism reproductive system", "genitalia of female organism", "reproductive system of female organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "female genital system", "female genital tract", "female genitalia", "female genitals", "female reproductive tract", "gynaecological tissue", "systema genitale femininum" ; oboInOwl:id "UBERON:0000474" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "female reproductive system" ; rdfs:subClassOf obo:UBERON_0000990, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000990 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg"^^xsd:anyURI . obo:UBERON_0000475 obo:IAO_0000115 "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." ; obo:IAO_0000116 "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010053", "AEO:0000032", "BILA:0000032", "BIRNLEX:7", "CALOHA:TS-2084", "CARO:0000032", "EFO:0000808", "EHDAA2:0003032", "EMAPA:36031", "FBbt:00007009", "FMA:7153", "HAO:0000032", "MA:0002433", "MAT:0000293", "MESH:D001829", "MIAA:0000293", "NCIT:C32221", "TAO:0001308", "TGMA:0001840", "UMLS:C0229962", "VHOG:0001758", "Wikipedia:Body_part", "XAO:0003013", "ZFA:0001308", "galen:BodyPart" ; oboInOwl:hasExactSynonym "anatomic region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body part", "body region", "cardinal body part" ; oboInOwl:id "UBERON:0000475" ; oboInOwl:inSubset core:common_anatomy, core:efo_slim, core:pheno_slim, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "organism subdivision" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] . obo:UBERON_0000476 obo:IAO_0000115 "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010268", "AEO:0000040", "BILA:0000040", "CARO:0000040", "EHDAA2:0003040", "FBbt:00007013", "FMA:63863", "HAO:0000040", "TAO:0000382", "TGMA:0001841", "XAO:0003162", "ZFA:0000382" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acellular anatomical structures" ; oboInOwl:id "UBERON:0000476" ; oboInOwl:inSubset core:common_anatomy, core:vertebrate_core ; a owl:Class ; rdfs:label "acellular anatomical structure" ; rdfs:subClassOf obo:UBERON_0000061 ; owl:disjointWith obo:UBERON_0010000 . obo:UBERON_0000477 obo:IAO_0000115 "Anatomical group whose component anatomical structures lie in close proximity to each other." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FBbt:00007277", "VHOG:0001737" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000477" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical cluster" ; rdfs:subClassOf obo:UBERON_0034923 . obo:UBERON_0000478 obo:IAO_0000115 "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." ; oboInOwl:hasDbXref "AAO:0010020", "AEO:0000042", "BILA:0000042", "CALOHA:TS-2119", "CARO:0000042", "EHDAA2:0003042", "EHDAA:46", "FBbt:00005835", "FMA:85537", "HAO:0000042", "NCIT:C34055", "SCTID:314908006", "TAO:0000020", "TGMA:0001843", "UMLS:C1282438", "VHOG:0000292", "XAO:0004005", "ZFA:0000020" ; oboInOwl:hasExactSynonym "extra-embryonic structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extraembryonic structures", "extraembryonic tissue" ; oboInOwl:id "UBERON:0000478" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "see also conceptus extraembryonic component in EHDAA2." ; rdfs:label "extraembryonic structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] ) ] . obo:UBERON_0000479 obo:IAO_0000115 "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." ; obo:IAO_0000116 "changed label and definition to reflect CARO2" ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0000607", "AAO:0010054", "AEO:0000043", "BILA:0000043", "BIRNLEX:19", "CALOHA:TS-2090", "CARO:0000043", "EHDAA2:0003043", "EMAPA:35868", "FBbt:00007003", "FMA:9637", "HAO:0000043", "MA:0003002", "MESH:D014024", "NCIT:C12801", "TAO:0001477", "TGMA:0001844", "UMLS:C0040300", "VHOG:0001757", "WBbt:0005729", "XAO:0003040", "ZFA:0001477", "galen:Tissue" ; oboInOwl:hasExactSynonym "portion of tissue", "tissue portion" ; oboInOwl:hasNarrowSynonym "simple tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000479" ; oboInOwl:inSubset core:common_anatomy, core:pheno_slim, core:upper_level ; a owl:Class ; rdfs:label "tissue" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031012 ] . obo:UBERON_0000481 obo:IAO_0000115 "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010048", "AEO:0000055", "BILA:0000055", "CARO:0000055", "EHDAA2:0003055", "FBbt:00007010", "HAO:0000055", "TAO:0001488", "TGMA:0001847", "VHOG:0001762", "XAO:0003037", "ZFA:0001488" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "multi-tissue structures" ; oboInOwl:id "UBERON:0000481" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "multi-tissue structure" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000479 ] . obo:UBERON_0000483 obo:IAO_0000115 "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." ; obo:UBPROP_0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" ; obo:UBPROP_0000007 "epithelial" ; oboInOwl:hasDbXref "AAO:0000144", "AAO:0010055", "AEO:0000066", "BILA:0000066", "BTO:0000416", "CALOHA:TS-0288", "CARO:0000066", "EHDAA2:0003066", "EMAPA:32738", "FBbt:00007005", "FMA:9639", "GAID:402", "HAO:0000066", "MA:0003060", "MESH:D004848", "NCIT:C12710", "SCTID:31610004", "TAO:0001486", "UMLS:C0014609", "VHOG:0000387", "Wikipedia:Epithelium", "XAO:0003045", "ZFA:0001486" ; oboInOwl:hasExactSynonym "epithelial tissue", "portion of epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000483" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?" ; rdfs:label "epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005911 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005769 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000066 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0000486 obo:UBERON_0000490 ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg"^^xsd:anyURI . obo:UBERON_0000484 obo:IAO_0000115 "Unilaminar epithelium that consists of a single layer of cuboidal cells." ; obo:IAO_0000116 "needs to be synchronized with CL - there is no distinct cuboidal cell in CL" ; oboInOwl:hasDbXref "AAO:0010064", "AEO:0000067", "BILA:0000067", "CARO:0000067", "EHDAA2:0003067", "FMA:45566", "HAO:0000067", "NCIT:C33553", "TAO:0001497", "UMLS:C0836134", "Wikipedia:Simple_cuboidal_epithelium", "XAO:0004009", "ZFA:0001497" ; oboInOwl:hasExactSynonym "epithelium simplex cuboideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "simple cuboidal epithelia" ; oboInOwl:id "UBERON:0000484" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "simple cuboidal epithelium" ; rdfs:subClassOf obo:UBERON_0000490, obo:UBERON_0010077 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png"^^xsd:anyURI . obo:UBERON_0000485 obo:IAO_0000115 "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." ; oboInOwl:hasBroadSynonym "columnar epithelium", "columnar epithlium" ; oboInOwl:hasDbXref "AAO:0010063", "AEO:0000068", "BILA:0000068", "CARO:0000068", "EHDAA2_RETIRED:0003068", "FBbt:00007027", "FMA:45567", "HAO:0000068", "NCIT:C33552", "SCTID:32210007", "TAO:0001496", "UMLS:C0836135", "Wikipedia:Simple_columnar_epithelium", "XAO:0004008", "ZFA:0001496" ; oboInOwl:hasExactSynonym "epithelium simplex columnare", "simple columnar epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "simple columnar epithelia" ; oboInOwl:id "UBERON:0000485" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "simple columnar epithelium" ; rdfs:subClassOf obo:UBERON_0000490, obo:UBERON_0012274 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png"^^xsd:anyURI . obo:UBERON_0000486 obo:IAO_0000115 "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." ; obo:UBPROP_0000001 "Epithelium that consists of more than one layer of epithelial cells.[CARO]" ; oboInOwl:hasDbXref "AAO:0010059", "AEO:0000069", "BILA:0000069", "BTO:0002074", "CARO:0000069", "EHDAA2:0003069", "FMA:45562", "HAO:0000069", "NCIT:C33622", "SCTID:309044005", "TAO:0001494", "UMLS:C0682575", "Wikipedia:Stratified_epithelium", "XAO:0004006", "ZFA:0001494" ; oboInOwl:hasExactSynonym "stratified epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laminated epithelium" ; oboInOwl:id "UBERON:0000486" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "multilaminar epithelium" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0000487 obo:IAO_0000115 "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." ; obo:UBPROP_0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" ; oboInOwl:hasDbXref "AAO:0010066", "AEO:0000070", "BILA:0000070", "BTO:0002073", "CARO:0000070", "EHDAA2:0003070", "FMA:45565", "HAO:0000070", "NCIT:C13178", "TAO:0001498", "UMLS:C0836133", "Wikipedia:Simple_squamous_epithelium", "XAO:0004010", "ZFA:0001498" ; oboInOwl:hasExactSynonym "epithelium simplex squamosum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "simple squamous epithelia" ; oboInOwl:id "UBERON:0000487" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "simple squamous epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000076 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg"^^xsd:anyURI . obo:UBERON_0000488 obo:IAO_0000115 "Epithelium that consists of epithelial cells not arranged in one ore more layers." ; oboInOwl:hasDbXref "AAO:0010057", "AEO:0000071", "BILA:0000071", "CARO:0000071", "EHDAA2:0003071", "FMA:61741", "HAO:0000071", "TAO:0001493", "XAO:0004004", "ZFA:0001493" ; oboInOwl:hasExactSynonym "heterogenous epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atypical epithelia" ; oboInOwl:id "UBERON:0000488" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "atypical epithelium" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0000489 obo:IAO_0000115 "Compound organ that contains one or more macroscopic anatomical spaces." ; obo:IAO_0000232 "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" ; oboInOwl:hasDbXref "AAO:0010016", "AEO:0000072", "BILA:0000072", "CARO:0000072", "EHDAA2:0003072", "FMA:55671", "HAO:0000072", "TAO:0001490", "TGMA:0001857", "VHOG:0001730", "XAO:0003165", "ZFA:0001490" ; oboInOwl:hasExactSynonym "cavitated organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitated compound organs" ; oboInOwl:id "UBERON:0000489" ; oboInOwl:inSubset core:organ_slim, core:upper_level ; a owl:Class ; rdfs:label "cavitated compound organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003103 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002553 ] ) ] . obo:UBERON_0000490 obo:IAO_0000115 "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." ; obo:IAO_0000116 "consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable" ; obo:UBPROP_0000001 "Epithelium that consists of a single layer of epithelial cells.[CARO]" ; oboInOwl:hasDbXref "AAO:0010062", "AEO:0000073", "BILA:0000073", "BTO:0002073", "CARO:0000073", "EHDAA2:0003073", "FMA:45561", "HAO:0000073", "NCIT:C33554", "SCTID:309043004", "TAO:0001495", "UMLS:C0682574", "XAO:0004007", "ZFA:0001495" ; oboInOwl:hasExactSynonym "simple epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "unilaminar epithelia" ; oboInOwl:id "UBERON:0000490" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "unilaminar epithelium" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0000642 obo:IAO_0000115 "A thin muscle connecting the junction between the duodenum, jejunum, and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery." ; oboInOwl:hasDbXref "FMA:20509", "SCTID:279979000", "Wikipedia:Suspensory_muscle_of_duodenum" ; oboInOwl:hasExactSynonym "ligament of Treitz", "muscle of Treitz", "musculus suspensorius duodeni", "suspensory muscle of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus suspensorius duodeni" ; oboInOwl:id "UBERON:0000642" ; a owl:Class ; rdfs:label "suspensory ligament of duodenum" ; rdfs:subClassOf obo:UBERON_0008841, _:genid112795, _:genid112797 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008841 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Gray1042.png"^^xsd:anyURI . obo:UBERON_0000912 obo:IAO_0000115 "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." ; obo:UBPROP_0000007 "mucoid", "mucous" ; oboInOwl:hasDbXref "CALOHA:TS-2144", "ENVO:02000040", "FMA:66938", "GAID:1164", "MESH:D009093", "NCIT:C13259", "UMLS:C0026727", "Wikipedia:Mucus", "galen:Mucus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000912" ; a owl:Class ; rdfs:label "mucus" ; rdfs:subClassOf obo:UBERON_0000456, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_37395 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000998 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000344 ] . obo:UBERON_0000913 obo:IAO_0000115 "Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid." ; obo:RO_0002171 obo:UBERON_0001969 ; oboInOwl:hasDbXref "ENVO:02000042", "FMA:9673", "NCIT:C120839", "Wikipedia:Interstitial_fluid" ; oboInOwl:hasExactSynonym "intercellular fluid", "tissue fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000913" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interstitial fluid" ; rdfs:subClassOf obo:UBERON_0000463, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000479 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:CL_0000000 ] . obo:UBERON_0000915 obo:IAO_0000115 "Subdivision of trunk that lies between the head and the abdomen." ; obo:IAO_0000232 "note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest" ; obo:RO_0002171 obo:UBERON_0000026, obo:UBERON_0000033, obo:UBERON_0002417 ; oboInOwl:hasDbXref "EMAPA:35862", "FMA:259209", "MA:0000022", "SCTID:302551006", "Wikipedia:Thorax" ; oboInOwl:hasExactSynonym "thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior subdivision of trunk", "upper body", "upper trunk" ; oboInOwl:id "UBERON:0000915" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "thoracic segment of trunk" ; rdfs:subClassOf obo:UBERON_0009569 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011676 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0014477 ] ) ] . obo:UBERON_0000916 obo:IAO_0000115 "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." ; obo:IAO_0000116 "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" ; obo:UBPROP_0000007 "abdominal", "celiac" ; oboInOwl:hasDbXref "BTO:0000020", "CALOHA:TS-0001", "EFO:0000968", "EMAPA:35102", "EV:0100011", "FMA:9577", "GAID:16", "MA:0000029", "MAT:0000298", "MESH:D000005", "MIAA:0000298", "SCTID:302553009", "Wikipedia:Abdomen", "galen:Abdomen" ; oboInOwl:hasExactSynonym "abdominopelvic region", "abdominopelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adult abdomen", "belly", "celiac region" ; oboInOwl:id "UBERON:0000916" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "abdomen" ; rdfs:subClassOf obo:UBERON_0009569, _:genid112823 . obo:UBERON_0000922 obo:IAO_0000115 "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." ; obo:UBPROP_0000007 "embryonic" ; obo:UBPROP_0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" ; oboInOwl:hasDbXref "AAO:0011035", "AEO:0000169", "BILA:0000056", "BSA:0000039", "BTO:0000379", "CALOHA:TS-0229", "EFO:0001367", "EHDAA2:0000002", "EHDAA2_RETIRED:0003236", "EHDAA:38", "EMAPA:16039", "FBbt:00000052", "FMA:69068", "GAID:963", "MAT:0000226", "MESH:D004622", "MIAA:0000019", "NCIT:C28147", "OGEM:000001", "SCTID:57991002", "UMLS:C0013935", "VHOG:0001766", "Wikipedia:Embryo", "XAO:0000113", "ZFA:0000103", "http://neurolex.org/wiki/Category:Embryonic_organism" ; oboInOwl:hasExactSynonym "embryonic organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "developing organism", "developmental tissue" ; oboInOwl:id "UBERON:0000922" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "embryo" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/503"^^xsd:anyURI ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002493 ; owl:someValuesFrom obo:UBERON_0000068 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg"^^xsd:anyURI . obo:UBERON_0000923 obo:IAO_0000115 "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." ; obo:UBPROP_0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "embryonic tissue" ; oboInOwl:hasDbXref "AAO:0000480", "BILA:0000035", "BTO:0000556", "EMAPA:36033", "FBbt:00000110", "FMA:69069", "GAID:1303", "MESH:D005855", "NCIT:C12950", "NCIT:C54105", "TAO:0001122", "UMLS:C0920502", "UMLS:C1708239", "VHOG:0001223", "Wikipedia:Germ_layer", "XAO:0003011", "ZFA:0001122" ; oboInOwl:hasExactSynonym "germinal layer" ; oboInOwl:hasNarrowSynonym "primary germ layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic germ layer", "embryonic germ layers" ; oboInOwl:id "UBERON:0000923" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]" ; rdfs:label "germ layer" ; rdfs:subClassOf obo:UBERON_0010316, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002532 ] . obo:UBERON_0000924 obo:IAO_0000115 "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." ; obo:UBPROP_0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" ; obo:UBPROP_0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" ; obo:UBPROP_0000007 "ectodermal" ; oboInOwl:hasDbXref "AAO:0000137", "BILA:0000036", "BTO:0000315", "CALOHA:TS-0216", "EFO:0000414", "EHDAA2:0000428", "EMAPA:16069", "EV:0100003", "FBbt:00000111", "FMA:69070", "GAID:1304", "MAT:0000155", "MAT:0000173", "MESH:D004475", "MIAA:0000173", "NCIT:C12703", "SCTID:362851007", "TAO:0000016", "UMLS:C0013574", "VHOG:0000153", "Wikipedia:Ectoderm", "XAO:0000001", "ZFA:0000016" ; oboInOwl:hasExactSynonym "embryonic ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000924" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ectoderm" ; rdfs:subClassOf obo:UBERON_0000923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000221 ], _:genid112849 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png"^^xsd:anyURI . obo:UBERON_0000925 obo:IAO_0000115 "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." ; obo:UBPROP_0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" ; obo:UBPROP_0000007 "endodermal" ; oboInOwl:hasDbXref "AAO:0000139", "BILA:0000038", "BTO:0000800", "CALOHA:TS-0273", "EFO:0002545", "EHDAA2:0000436", "EMAPA:16062", "EV:0100005", "FBbt:00000125", "FMA:69071", "GAID:1305", "MAT:0000175", "MESH:D004707", "MIAA:0000175", "NCIT:C12706", "SCTID:362855003", "TAO:0000017", "UMLS:C0014144", "VHOG:0000154", "Wikipedia:Endoderm", "XAO:0000090", "ZFA:0000017" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "entoderm" ; oboInOwl:id "UBERON:0000925" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endoderm" ; rdfs:subClassOf obo:UBERON_0000923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000223 ], _:genid112857 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png"^^xsd:anyURI . obo:UBERON_0000926 obo:IAO_0000115 "The middle germ layer of the embryo, between the endoderm and ectoderm." ; obo:RO_0002161 obo:NCBITaxon_6040 ; obo:UBPROP_0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" ; obo:UBPROP_0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" ; obo:UBPROP_0000007 "mesodermal" ; obo:UBPROP_0000008 "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" ; oboInOwl:hasAlternativeId "UBERON:0003263" ; oboInOwl:hasDbXref "AAO:0000304", "BILA:0000037", "BTO:0000839", "CALOHA:TS-0623", "EFO:0001981", "EHDAA2:0001128", "EHDAA:124", "EHDAA:160", "EHDAA:183", "EMAPA:16083", "EV:0100006", "FBbt:00000126", "FMA:69072", "GAID:522", "MAT:0000174", "MESH:D008648", "MIAA:0000174", "NCIT:C12750", "SCTID:362854004", "TAO:0000041", "UMLS:C0025485", "VHOG:0000152", "Wikipedia:Mesoderm", "XAO:0000050", "ZFA:0000041" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic mesoderm", "entire mesoderm", "mesodermal mantle" ; oboInOwl:id "UBERON:0000926" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesoderm" ; rdfs:subClassOf obo:UBERON_0000923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000222 ], _:genid112865 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png"^^xsd:anyURI . obo:UBERON_0000929 obo:IAO_0000115 "Motor nerve of the pharynx, arises from the upper part of the ganglion nodosum, and consists principally of filaments from the cranial portion of the accessory nerve." ; oboInOwl:hasDbXref "FMA:6234", "SCTID:280298006", "Wikipedia:Pharyngeal_part_of_vagus_nerve" ; oboInOwl:hasExactSynonym "pharyngeal branch", "pharyngeal branch of inferior vagal ganglion", "pharyngeal branch of vagus", "ramus pharyngealis nervi vagalis", "ramus pharyngeus", "tenth cranial nerve pharyngeal branch", "vagal pharyngeal branch", "vagus nerve pharyngeal branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ramus pharyngeus nervi vagi" ; oboInOwl:id "UBERON:0000929" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "pharyngeal branch of vagus nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001005 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001759 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0005363 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png"^^xsd:anyURI . obo:UBERON_0000930 obo:IAO_0000115 "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." ; obo:IAO_0000116 "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" ; obo:UBPROP_0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]", "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" ; obo:UBPROP_0000007 "stomodeal" ; obo:UBPROP_0000008 "This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity." ; oboInOwl:hasBroadSynonym "stomodeal-hypophyseal primordium" ; oboInOwl:hasDbXref "BTO:0004224", "EHDAA2:0001929", "EMAPA:16263", "FBbt:00000439", "FMA:295846", "NCIT:C34306", "TAO:0001290", "TGMA:0000135", "UMLS:C1514977", "Wikipedia:Stomodeum", "XAO:0000269", "ZFA:0001290" ; oboInOwl:hasExactSynonym "mouth primordium", "primitive oral cavity", "stomatodeum", "stomodaeum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mouth pit", "oral ectoderm", "oral pit" ; oboInOwl:id "UBERON:0000930" ; oboInOwl:inSubset core:grouping_class, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "stomodeum" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ], _:genid112795 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png"^^xsd:anyURI . obo:UBERON_0000931 obo:IAO_0000115 "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." ; obo:IAO_0000116 "removed WBbt:0006795 'proctodeum' - junction between the alimentary and genital tracts in the male." ; obo:UBPROP_0000001 "An inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[TAO]", "Inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[AAO]" ; obo:UBPROP_0000007 "proctodeal" ; oboInOwl:hasDbXref "AAO:0011087", "EHDAA2:0000121", "EMAPA:25038", "FBbt:00000123", "NCIT:C34278", "TAO:0000066", "UMLS:C0231054", "VHOG:0000139", "Wikipedia:Proctodeum", "XAO:0001019", "ZFA:0000066" ; oboInOwl:hasExactSynonym "embryonic proctodaeum", "proctodaeum" ; oboInOwl:hasNarrowSynonym "amnioproctodeal invagination" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anal pit", "anus porus" ; oboInOwl:id "UBERON:0000931" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "proctodeum" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/685"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0016566, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001353 ], _:genid112902 . obo:UBERON_0000933 obo:IAO_0000115 "A muscle that acts on the pharynx[WP, vetted]." ; obo:UBPROP_0000001 "A pharyngeal muscle is any muscle that forms part of the pharynx[GO]." ; obo:UBPROP_0000202 obo:FMA_67169 ; oboInOwl:hasDbXref "BTO:0001048", "EFO:0003504", "EMAPA:18963", "FMA:46619", "GAID:154", "MA:0001797", "MESH:D010609", "NCIT:C13075", "SCTID:244798004", "TAO:0000172", "UMLS:C0031346", "Wikipedia:Pharyngeal_muscles", "ZFA:0000172" ; oboInOwl:hasExactSynonym "branchial muscle", "muscle of pharynx", "muscle organ of pharynx", "pharyngeal muscle", "pharynx muscle", "pharynx muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial muscles", "musculi pharyngis", "musculus pharyngis", "tunica muscularis pharyngis" ; oboInOwl:id "UBERON:0000933" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "Innervation notes: They are innervated by the pharyngeal branch of the Vagus nerve (CN X) with the exception of the stylopharyngeus muscle which is innervated by the glossopharyngeal nerve (CN IX).[WP]" ; rdfs:label "chordate pharyngeal muscle" ; rdfs:subClassOf _:genid112823 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004467 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray1030.png"^^xsd:anyURI . obo:UBERON_0000935 obo:IAO_0000115 "A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris)." ; obo:UBPROP_0000003 "In all vertebrates the thin structure that connects the two halves of the telencephalon shows a ridge-like thickening at the basal side known as the anterior commissure.[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:AC", "BAMS:AG", "BAMS:Ac", "BAMS:ac", "BIRNLEX:1557", "BM:Tel-AC", "BTO:0002169", "DHBA:10559", "DMBA:17751", "EMAPA:19038", "FMA:61961", "HBA:9221", "MA:0002722", "NCIT:C32086", "NLX:144088", "SCTID:279313001", "SCTID:369119009", "TAO:0001108", "UMLS:C0152335", "VHOG:0001558", "Wikipedia:Anterior_commissure", "ZFA:0001108", "neuronames:205" ; oboInOwl:hasExactSynonym "anterior cerebral commissure", "commissura anterior cerebri", "commissura rostralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "AC", "anterior commissural nucleus", "commissura anterior", "commissura rostral", "paleocortical commissure", "precommisure", "rostral commissure" ; oboInOwl:id "UBERON:0000935" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "anterior commissure" ; rdfs:subClassOf obo:UBERON_0002473, obo:UBERON_0005341 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray744.png"^^xsd:anyURI . obo:UBERON_0000941 obo:IAO_0000115 "Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]." ; obo:IAO_0000116 "Do not classify under 'cranial nerve', as this is not a true nerve - should be classified as evaginated sensory afferent[ISBN:0471888893]" ; obo:UBPROP_0000001 "A collection of nerve cells that project visual information from the eyes to the brain. (Source: BioGlossary, www.Biology-Text.com)[TAO]", "Fibrous, somatic sensory element covered by a fibrous connective-tissue sheath and is continuous with the layer of nerve cells on the inner surface of the eye.[AAO]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup (reference 1); The (optic) stalk persists as the optic nerve (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "(relaion to eye): MA, XAO, AAO and BTO consider this part of the eye. This is in contrast to GO, FMA, EHDAA2 (FMA has a class 'intra-ocular part of optic nerve' which represents the region of overlap). Relation to brain: part of diencephalon in EHDAA2, ZFA. In NIF, has the optic nerve root as part, which is a feature part of the diencphalon" ; oboInOwl:hasBroadSynonym "2n", "optic nerve" ; oboInOwl:hasDbXref "AAO:0010345", "BAMS:2n", "BAMS:IIn", "BAMS:nII", "BIRNLEX:1640", "CALOHA:TS-0713", "DHBA:15544", "EFO:0004258", "EHDAA2:0001313", "EHDAA:6788", "EMAPA:17575", "FMA:50863", "GAID:831", "HBA:9307", "MA:0001097", "MBA:848", "MESH:D009900", "NCIT:C12761", "SCTID:180938001", "TAO:0000435", "UMLS:C0029130", "VHOG:0000543", "Wikipedia:Optic_nerve", "XAO:0000188", "ZFA:0000435", "neuronames:289" ; oboInOwl:hasExactSynonym "02 optic nerve", "cranial II", "nervus opticus", "nervus opticus [II]", "optic II", "optic II nerve", "optic nerve [II]", "second cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-II", "nerve II", "optic" ; oboInOwl:id "UBERON:0000941" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cranial nerve II" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002104 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0003098 ], _:genid112949 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034713 _:genid112849 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000959 ] ) ] . obo:UBERON_0000945 obo:IAO_0000115 "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." ; obo:RO_0002161 obo:NCBITaxon_7878, obo:NCBITaxon_9259 ; obo:UBPROP_0000001 "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]" ; obo:UBPROP_0000003 "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]" ; obo:UBPROP_0000008 "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa" ; oboInOwl:hasDbXref "AAO:0000579", "ANISEED:1235297", "BTO:0001307", "CALOHA:TS-0980", "EFO:0000837", "EHDAA2:0001915", "EHDAA:2993", "EMAPA:17021", "EV:0100070", "FMA:7148", "GAID:293", "MA:0000353", "MAT:0000051", "MESH:D013270", "MIAA:0000051", "NCIT:C12391", "SCTID:181246003", "TAO:0002121", "UMLS:C0038351", "VHOG:0000408", "Wikipedia:Stomach", "XAO:0000128", "galen:Stomach" ; oboInOwl:hasNarrowSynonym "stomach chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior intestine", "gaster", "mesenteron", "ventriculus" ; oboInOwl:id "UBERON:0000945" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "stomach" ; rdfs:subClassOf obo:UBERON_0004921, obo:UBERON_0010039, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001007 ], _:genid112972 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg"^^xsd:anyURI . obo:UBERON_0000946 obo:IAO_0000115 "A membranous fold of the heart that prevents reflux of fluid." ; obo:UBPROP_0000001 "One of the four structures within the heart that prevent backflow of blood by opening and closing with each heartbeat. The valves include two semilunar valves, the aortic and pulmonary; the mitral or bicuspid valve; and the tricuspid valve. The valves permit blood flow in only one direction. [TFD][VHOG]" ; obo:UBPROP_0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" ; obo:UBPROP_0000013 "Rector et al: One might be tempted to define 'heart valve' equivalently to 'valve in the heart', and 'valve' as a 'structure which functions as a valve'. But this combination results in the 'foramen ovale' being classified as a kind of 'heart valve', since it is undoubtedly located in the heart and functions as a valve" ; oboInOwl:hasDbXref "BTO:0000564", "EMAPA:17869", "EV:0100024", "FMA:7110", "GAID:176", "MA:0000086", "MESH:D006351", "NCIT:C12729", "SCTID:181285005", "TAO:0005065", "UMLS:C0018826", "VHOG:0000818", "Wikipedia:Cardiac_valve", "XAO:0004126", "ZFA:0005065", "galen:HeartValve" ; oboInOwl:hasExactSynonym "heart valve", "valve of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "heart valve", "heart valves", "stomodaeal valve", "valvule" ; oboInOwl:id "UBERON:0000946" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cardiac valve" ; rdfs:subClassOf obo:UBERON_0003978, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], _:genid112985 . obo:UBERON_0000947 obo:IAO_0000115 "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." ; obo:IAO_0000116 "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." ; obo:UBPROP_0000001 "The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]" ; obo:UBPROP_0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" ; obo:UBPROP_0000007 "aortic" ; obo:UBPROP_0000008 "All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches" ; oboInOwl:hasDbXref "AAO:0010213", "BTO:0000135", "CALOHA:TS-0046", "EFO:0000265", "EMAPA:18601", "EV:0100027", "FMA:3734", "GAID:469", "MA:0000062", "MAT:0000035", "MESH:D001011", "MIAA:0000035", "NCIT:C12669", "SCTID:181298001", "UMLS:C0003483", "VHOG:0001523", "Wikipedia:Aorta", "XAO:0003010", "galen:Aorta" ; oboInOwl:hasExactSynonym "trunk of aortic tree", "trunk of systemic arterial tree" ; oboInOwl:hasNarrowSynonym "dorsal aorta" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria maxima" ; oboInOwl:id "UBERON:0000947" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "aorta" ; rdfs:subClassOf obo:UBERON_0003509, obo:UBERON_0013768, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002084 ], _:genid112993, _:genid112995 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg"^^xsd:anyURI . obo:UBERON_0000948 obo:IAO_0000115 "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." ; obo:UBPROP_0000001 "Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]", "Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" ; obo:UBPROP_0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]" ; obo:UBPROP_0000007 "cardiac" ; oboInOwl:hasDbXref "AAO:0010210", "BILA:0000020", "BTO:0000562", "CALOHA:TS-0445", "EFO:0000815", "EHDAA2:0000738", "EHDAA:420", "EMAPA:16105", "EV:0100018", "FMA:7088", "GAID:174", "MA:0000072", "MAT:0000036", "MESH:D006321", "MIAA:0000036", "NCIT:C12727", "SCTID:302509004", "TAO:0000114", "UMLS:C0018787", "VHOG:0000276", "Wikipedia:Heart", "XAO:0000064", "ZFA:0000114", "galen:Heart" ; oboInOwl:hasExactSynonym "chambered heart", "vertebrate heart" ; oboInOwl:hasNarrowSynonym "branchial heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardium" ; oboInOwl:id "UBERON:0000948" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Taxon notes:\" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)\" DOI:10.1101/gad.1485706" ; rdfs:label "heart" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004141 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004535 ], _:genid113009, _:genid113012 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007100 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004151 ] ) ] . obo:UBERON_0000949 obo:IAO_0000115 "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." ; obo:UBPROP_0000001 "Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]" ; obo:UBPROP_0000003 "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" ; obo:UBPROP_0000007 "endocrine" ; oboInOwl:hasDbXref "AAO:0010279", "CALOHA:TS-1301", "EFO:0002969", "EHDAA2:0002224", "EMAPA:35306", "EV:0100128", "FBbt:00005068", "FMA:9668", "GAID:439", "MA:0000012", "MESH:D004703", "NCIT:C12705", "SCTID:278876000", "TAO:0001158", "UMLS:C0014136", "VHOG:0000098", "Wikipedia:Endocrine_system", "XAO:0000158", "ZFA:0001158" ; oboInOwl:hasExactSynonym "endocrine glandular system", "endocrine system", "systema endocrinum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000949" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endocrine system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002368 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0000990, obo:UBERON_0001004, obo:UBERON_0001007, obo:UBERON_0001009, obo:UBERON_0001016, obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015203 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050886 ] ) ] . obo:UBERON_0000951 obo:IAO_0000115 "Any of a number of short transversospinal muscles chiefly developed in cervical, lumbar, and thoracic regions, arising from the transverse process of one vertebra and inserted into the root of the spinous process of the next two or three vertebrae above, with nerve supply from the dorsal branches of the spinal nerve, and whose actions rotate the vertebral column." ; oboInOwl:hasBroadSynonym "rotator muscle" ; oboInOwl:hasDbXref "FMA:23081", "SCTID:244872002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000951" ; a owl:Class ; rdfs:label "rotator muscle of the vertebral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001077 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001076 ] ) ] . obo:UBERON_0000955 obo:IAO_0000115 "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." ; obo:IAO_0000116 "requires review for applicability to invertebrate structures, e.g. synganglion" ; obo:UBPROP_0000001 "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]", "Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]", "The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010478", "ABA:Brain", "BAMS:Br", "BAMS:Brain", "BILA:0000135", "BIRNLEX:796", "BTO:0000142", "CALOHA:TS-0095", "DHBA:10155", "EFO:0000302", "EHDAA2:0000183", "EHDAA:2641", "EHDAA:6485", "EMAPA:16894", "EV:0100164", "FBbt:00005095", "FMA:50801", "GAID:571", "HBA:4005", "MA:0000168", "MAT:0000098", "MBA:8", "MBA:997", "MESH:D001921", "MIAA:0000098", "NCIT:C12439", "PBA:3999", "SCTID:258335003", "TAO:0000008", "UMLS:C0006104", "UMLS:C1269537", "VHOG:0000157", "Wikipedia:Brain", "XAO:0000010", "ZFA:0000008", "galen:Brain", "neuronames:21" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "encephalon", "suprasegmental levels of nervous system", "suprasegmental structures", "synganglion", "the brain" ; oboInOwl:id "UBERON:0000955" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:human_reference_atlas, core:major_organ, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "brain" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid113046, _:genid113052 . obo:UBERON_0000956 obo:IAO_0000115 "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." ; obo:IAO_0000232 "We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus)." ; obo:UBPROP_0000001 "The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]." ; obo:UBPROP_0000003 "Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]" ; obo:UBPROP_0000008 "hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743]" ; oboInOwl:hasDbXref "BAMS:C", "BAMS:CTX", "BAMS:Cerebral_cortex", "BAMS:Cx", "BIRNLEX:1494", "BM:Tel-Cx", "BTO:0000233", "CALOHA:TS-0091", "DHBA:10159", "EFO:0000328", "EHDAA2:0000234", "EHDAA:5464", "EMAPA:17544", "EV:0100166", "FMA:61830", "GAID:629", "HBA:4008", "MA:0000185", "MAT:0000108", "MBA:688", "MESH:D002540", "MIAA:0000108", "NCIT:C12443", "PBA:128011354", "SCTID:362880003", "UMLS:C0007776", "VHOG:0000722", "Wikipedia:Cerebral_cortex", "neuronames:39" ; oboInOwl:hasExactSynonym "cortex of cerebral hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain cortex", "cortex cerebralis", "cortex cerebri", "cortical plate (CTXpl)", "cortical plate (areas)", "pallium of the brain" ; oboInOwl:id "UBERON:0000956" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cerebral cortex" ; rdfs:subClassOf obo:UBERON_0016548, [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0004035 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001893 ], _:genid113067, _:genid113069, _:genid113071 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg"^^xsd:anyURI . obo:UBERON_0000957 obo:IAO_0000115 "Any thin layer or plate." ; obo:IAO_0000116 "TODO - merge with cell layer?" ; obo:UBPROP_0000007 "laminar" ; oboInOwl:hasDbXref "Wikipedia:Lamina_of_the_vertebral_arch" ; oboInOwl:hasExactSynonym "laminar tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000957" ; oboInOwl:inSubset core:non_informative, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "lamina" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002124 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png"^^xsd:anyURI . obo:UBERON_0000958 obo:IAO_0000115 "Middle part of an organ, surrounded by the cortex." ; obo:IAO_0000232 "this class is used in a very general sense" ; obo:UBPROP_0000007 "medullary" ; oboInOwl:hasDbXref "FMA:61108", "galen:Medulla" ; oboInOwl:hasExactSynonym "medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000958" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "medulla of organ" ; rdfs:subClassOf obo:UBERON_0000471, [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0001851 ] . obo:UBERON_0000959 obo:IAO_0000115 "A decussation of the diencephalon where the fibers of the optic nerve cross." ; obo:UBPROP_0000001 "The point at which fibers of the optic nerves cross.[AAO]" ; obo:UBPROP_0000003 "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" ; oboInOwl:hasDbXref "AAO:0010622", "BAMS:DC", "BAMS:OC", "BAMS:och", "BAMS:ox", "BIRNLEX:1416", "BM:Tel-OCX", "DHBA:10644", "DMBA:17783", "EHDAA2:0001302", "EHDAA:10227", "EMAPA:17603", "FMA:62045", "GAID:832", "HBA:9310", "MA:0001098", "MBA:117", "MESH:D009897", "NCIT:C90609", "SCTID:244453006", "TAO:0000556", "UMLS:C0029126", "VHOG:0000190", "Wikipedia:Optic_chiasm", "XAO:0004071", "ZFA:0000556", "neuronames:459" ; oboInOwl:hasExactSynonym "chiasma opticum", "decussation of optic nerve fibers", "optic chiasm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chiasma", "chiasma nervorum opticorum", "optic chiasm (Rufus of Ephesus)" ; oboInOwl:id "UBERON:0000959" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "optic chiasma" ; rdfs:subClassOf obo:UBERON_0007418 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000941 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001908 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg"^^xsd:anyURI . obo:UBERON_0000962 obo:IAO_0000115 "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." ; oboInOwl:hasDbXref "BAMS:cern", "FMA:5859", "NCIT:C32299", "NLXANAT:20090207", "SCTID:360497008", "UMLS:C0228815", "Wikipedia:Cervical_nerves", "neuronames:2351" ; oboInOwl:hasExactSynonym "cervical nerve", "cervical nerve tree", "cervical spinal nerve", "nervus cervicalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000962" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]" ; rdfs:label "nerve of cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001780 _:genid113012 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png"^^xsd:anyURI . obo:UBERON_0000964 obo:IAO_0000115 "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." ; obo:UBPROP_0000007 "corneal" ; obo:UBPROP_0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" ; oboInOwl:hasDbXref "AAO:0010344", "BTO:0000286", "CALOHA:TS-0171", "EFO:0000377", "EHDAA2:0000316", "EHDAA:10199", "EMAPA:17161", "EV:0100341", "FMA:58238", "GAID:892", "MA:0000266", "MESH:D003315", "NCIT:C12342", "SCTID:181162001", "TAO:0000640", "UMLS:C0010031", "VHOG:0000164", "Wikipedia:Cornea", "XAO:0000180", "ZFA:0000640" ; oboInOwl:hasExactSynonym "cornea of camera-type eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corneas", "tunica cornea" ; oboInOwl:id "UBERON:0000964" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cornea" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001772 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000964 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001773 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005427 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0005426 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001801 ], _:genid113124, _:genid113126, _:genid113128, _:genid113134 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0000965 obo:IAO_0000115 "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." ; obo:RO_0002171 obo:UBERON_0002049 ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; obo:UBPROP_0000008 "This class excludes compound eye corneal lenses." ; oboInOwl:hasDbXref "AAO:0010348", "BTO:0000723", "CALOHA:TS-0545", "EHDAA:9057", "EMAPA:17838", "EV:0100343", "FMA:58241", "MA:0000275", "MAT:0000141", "MESH:D007908", "MIAA:0000141", "NCIT:C12743", "RETIRED_EHDAA2:0000975", "SCTID:181169005", "TAO:0000035", "UMLS:C0023317", "VHOG:0000169", "Wikipedia:Lens_(anatomy)", "XAO:0000008", "ZFA:0000035" ; oboInOwl:hasExactSynonym "camera-type eye lens", "eye lens", "lens", "lens crystallina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crystalline lens", "lenses", "ocular lens" ; oboInOwl:id "UBERON:0000965" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "The lens is avascular and nourished by diffusion from the aqueous and vitreous humors." ; rdfs:label "lens of camera-type eye" ; rdfs:subClassOf obo:UBERON_0005389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003073 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005426 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001801 ] . obo:UBERON_0000966 obo:IAO_0000115 "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." ; obo:UBPROP_0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; obo:UBPROP_0000007 "retinal" ; oboInOwl:hasDbXref "AAO:0010352", "BAMS:R", "BIRNLEX:1153", "BTO:0001175", "CALOHA:TS-0865", "EFO:0000832", "EHDAA2:0001627", "EHDAA:4757", "EMAPA:17168", "EV:0100348", "FMA:58301", "GAID:755", "MA:0000276", "MAT:0000142", "MBA:304325711", "MESH:D012160", "MIAA:0000142", "NCIT:C12343", "NIFSTD_RETIRED:birnlex_1156", "SCTID:181171005", "TAO:0000152", "UMLS:C0035298", "UMLS:C1278894", "VHOG:0000229", "Wikipedia:Retina", "XAO:0000009", "ZFA:0000152", "neuronames:1862" ; oboInOwl:hasExactSynonym "inner layer of eyeball", "retina of camera-type eye", "tunica interna of eyeball" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Netzhaut", "retinas" ; oboInOwl:id "UBERON:0000966" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods" ; rdfs:label "retina" ; rdfs:subClassOf obo:UBERON_0005388, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001802 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0019207 ], _:genid113160, _:genid113162, _:genid113164, _:genid113166 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png"^^xsd:anyURI . obo:UBERON_0000970 obo:IAO_0000115 "An organ that detects light." ; obo:IAO_0000232 "This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)" ; obo:UBPROP_0000007 "ocular", "optic" ; obo:UBPROP_0000010 "Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva," ; oboInOwl:hasDbXref "BILA:0000017", "BTO:0000439", "CALOHA:TS-0309", "EFO:0000827", "EV:0100336", "FBbt:00005162", "GAID:69", "MAT:0000140", "MESH:D005123", "MIAA:0000140", "Wikipedia:Eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "light-detecting organ", "visual apparatus" ; oboInOwl:id "UBERON:0000970" ; oboInOwl:inSubset core:efo_slim, core:functional_classification, core:human_reference_atlas, core:major_organ, core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:label "eye" ; rdfs:subClassOf obo:UBERON_0000020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002104 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0009584 ], _:genid113177, _:genid113179 . obo:UBERON_0000974 obo:IAO_0000115 "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." ; obo:IAO_0000232 "true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck." ; obo:UBPROP_0000007 "cervical" ; oboInOwl:hasDbXref "AEO:0000108", "BTO:0000420", "CALOHA:TS-2045", "EFO:0000967", "EHDAA2:0003108", "EMAPA:35587", "FMA:7155", "GAID:86", "MA:0000024", "MAT:0000297", "MESH:D009333", "MIAA:0000297", "NCIT:C13063", "SCTID:302550007", "UMLS:C0027530", "Wikipedia:Neck", "galen:Neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "collum", "neck (volume)" ; oboInOwl:id "UBERON:0000974" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "neck" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], _:genid113069, [ a owl:Restriction ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid113071 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg"^^xsd:anyURI . obo:UBERON_0000975 obo:IAO_0000115 "A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad]." ; obo:IAO_0000116 "in EMAPA and EHDAA2 this is part of the skeleton of pectoral girdle; the classic def of pectoral girdle (see WP) excludes the rib cage and sternum" ; obo:UBPROP_0000001 "Single element that constitutes the postzonal area of the pectoral girdle.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of postzonal element (AAO:0000938)[AAO]" ; obo:UBPROP_0000003 "Fishes lack a sternum. (...) A sternum is absent in the first fossil tetrapods, but it is present in modern amphibians. (...) Thus, a sternum occurs in some modern amphibians, birds, mammals and archosaurs. However, its absence in the common ancestors to these groups means that it has arisen independently several times within the field of the midventral connective tissue.[well established][VHOG]" ; obo:UBPROP_0000007 "sternal" ; obo:UBPROP_0000008 "It probably first evolved in early tetrapods as an extension of the pectoral girdle; it is not found in fish. In amphibians and reptiles it is typically a shield-shaped structure, often composed entirely of cartilage. It is absent in both turtles and snakes. In birds it is a relatively large bone and typically bears an enormous projecting keel to which the flight muscles are attached. Only in mammals does the sternum take on the elongated, segmented form seen in humans. In some mammals, such as opossums, the individual segments never fuse and remain separated by cartilagenous plates throughout life", "in birds, either ratite (no keel or carina) or carinate (keel and carina present)" ; obo:UBPROP_0000011 "While its developmental origins are similar to the ribs (from the myospetum and septum of the trunk region), it is often associated with the pectoral skeleton, due to both function and physical connections (i.e. the coracoid of archosaurs). It may be a single element or a series of smaller structure (sternebrae). Based on Kardong 2012. [PHENOSCAPE:ad]." ; oboInOwl:hasDbXref "AAO:0000765", "BTO:0001302", "CALOHA:TS-0972", "EHDAA2:0001914", "EHDAA:9561", "EMAPA:18344", "FMA:7485", "GAID:246", "MA:0001331", "MESH:D013249", "NCIT:C12793", "SCTID:302522007", "UMLS:C0038293", "VHOG:0000856", "Wikipedia:Sternum", "galen:Sternum" ; oboInOwl:hasExactSynonym "vertebrate sternum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "breastbone" ; oboInOwl:id "UBERON:0000975" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sternum" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002228 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0007831 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003252 ], _:genid113194 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg"^^xsd:anyURI . obo:UBERON_0000976 obo:IAO_0000115 "Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah]." ; obo:UBPROP_0000001 "Paired, elongate, cylindrical bones of endochondral origin that extend from the pectoral girdle to the elbows.[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000007 "humeral" ; oboInOwl:hasDbXref "AAO:0000679", "CALOHA:TS-2202", "EFO:0001398", "EMAPA:19106", "FMA:13303", "GAID:183", "MA:0001356", "MESH:D006811", "NCIT:C12731", "SCTID:181923006", "UMLS:C0020164", "VHOG:0001158", "Wikipedia:Humerus", "XAO:0003210", "galen:Humerus" ; oboInOwl:hasExactSynonym "humeri", "humerus bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesomere 1 of pectoral appendage", "proximal metapterygial mesomere of pectoral appendage", "proximal metapterygial mesomere of pectoral fin" ; oboInOwl:id "UBERON:0000976" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "humerus" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001470 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0007831 ], _:genid113211, _:genid113213, _:genid113216 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015053 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg"^^xsd:anyURI . obo:UBERON_0000977 obo:IAO_0000115 "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." ; obo:UBPROP_0000001 "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" ; obo:UBPROP_0000007 "pleural" ; obo:UBPROP_0000012 "In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86" ; oboInOwl:hasDbXref "BTO:0001791", "CALOHA:TS-2081", "EFO:0001980", "EMAPA:16775", "EV:0100044", "FMA:9583", "GAID:360", "MA:0000433", "MESH:D010994", "NCIT:C12469", "SCTID:181609007", "UMLS:C0032225", "VHOG:0000394", "Wikipedia:Pleura" ; oboInOwl:hasExactSynonym "wall of pleural sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pleura", "pleural tissue" ; oboInOwl:id "UBERON:0000977" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pleura" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001748 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ], _:genid113236 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009778 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002400 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002401 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png"^^xsd:anyURI . obo:UBERON_0000978 obo:IAO_0000115 "The portion of the hindlimb that contains both the stylopod and zeugopod." ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000013 "The term leg can mean: [1] an appendage on which an animal walks [2] the entire hindlimb of a tetrapod [3] the segment of a human leg between knee and ankle (cf FMA) [4] the region of a hindlimb include the stylopod and zeugopod, but excluding the autopod. We define this class as [4], and thus 'leg' is compltely analagous to 'arm'. For [1], see the class 'locomotive weight-bearing appendage'. For [2] we use 'hindlimb'. For" ; oboInOwl:hasDbXref "BTO:0000721", "CALOHA:TS-2206", "EFO:0001411", "EHDAA2:0000972", "EHDAA:5151", "EHDAA:6176", "EHDAA:8289", "EMAPA:17489", "GAID:49", "MA:0000047", "MESH:D035002", "VHOG:0000345", "Wikipedia:Leg#Limb" ; oboInOwl:hasExactSynonym "tetrapod leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower extremity" ; oboInOwl:id "UBERON:0000978" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "we use the less open to misinterpretation 'hindlimb zeugopod'. Editor note: currently declared as overlapping foot, as AOs disagree over whether some ankle parts are in the leg or foot" ; rdfs:label "leg" ; rdfs:subClassOf obo:UBERON_0006058, _:genid113124, [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0002387 ], _:genid113126 . obo:UBERON_0000979 obo:IAO_0000115 "The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]." ; obo:UBPROP_0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a straight, simple bone whose section is more or less rectangular at the ends and circular at its central portion.[AAO]" ; oboInOwl:hasDbXref "AAO:0000890", "BTO:0001252", "CALOHA:TS-1048", "EFO:0003054", "EMAPA:19142", "FMA:24476", "GAID:204", "MA:0001361", "MESH:D013977", "NCIT:C12800", "SCTID:182061009", "UMLS:C0040184", "Wikipedia:Tibia", "galen:Tibia" ; oboInOwl:hasExactSynonym "shankbone", "shinbone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000979" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tibia" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0010720 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010849 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015004 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray260.png"^^xsd:anyURI . obo:UBERON_0000980 obo:IAO_0000115 "A bony prominence near the extremity of the femur that normally serves as attachment points for hip and thigh muscles[MP,modified]." ; obo:UBPROP_0000001 "Process on the ventral surface of the shaft of the femur.[AAO]" ; obo:UBPROP_0000008 "there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third)" ; oboInOwl:hasDbXref "AAO:0000897", "FMA:82513", "MA:0002821", "NCIT:C33814", "SCTID:182047004", "UMLS:C0162370", "Wikipedia:Trochanter" ; oboInOwl:hasExactSynonym "femoral trochanter", "trochanter of femur" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000980" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "trochanter" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000981 ], _:genid113266 . obo:UBERON_0000981 obo:IAO_0000115 "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified]." ; obo:UBPROP_0000001 "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium.[VSAO]", "Paired, elongate, cylindrical bones of endochondral origin that form the thighs, extending from the pelvic girdles to the knees.[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000007 "femoral" ; oboInOwl:hasDbXref "AAO:0000887", "AAO:0000889", "BTO:0001284", "CALOHA:TS-0322", "EFO:0001396", "EMAPA:19143", "FMA:9611", "GAID:199", "MA:0001359", "MESH:D005269", "NCIT:C12717", "SCTID:182046008", "UMLS:C0015811", "VHOG:0001159", "VSAO:0000186", "Wikipedia:Femur", "XAO:0003214", "galen:Femur" ; oboInOwl:hasExactSynonym "thigh bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "femoral bone", "mesomere 1 of pevlic appendage", "os femorale", "os femoris", "os longissimum", "proximal metapterygial mesomere of pelvic appendage", "proximal metapterygial mesomere of pelvic fin" ; oboInOwl:id "UBERON:0000981" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "femur" ; rdfs:subClassOf obo:UBERON_0002495, obo:UBERON_0008202, [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0007832 ], _:genid113279, _:genid113281, _:genid113283 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015052 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/73/Gray252.png"^^xsd:anyURI . obo:UBERON_0000982 obo:IAO_0000115 "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." ; obo:UBPROP_0000001 "Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]", "Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]" ; oboInOwl:hasBroadSynonym "articulation", "joint" ; oboInOwl:hasDbXref "AEO:0000182", "BTO:0001686", "CALOHA:TS-2023", "EFO:0000948", "EMAPA:35456", "FMA:7490", "GAID:102", "MA:0000319", "MAT:0000188", "MESH:D007596", "MIAA:0000188", "NCIT:C13044", "RETIRED_EHDAA2:0003182", "SCTID:302536002", "TAO:0000367", "UMLS:C0022417", "VHOG:0001276", "VSAO:0000101", "Wikipedia:Joint", "XAO:0000171", "ZFA:0001596", "galen:Joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articular joint", "joints" ; oboInOwl:id "UBERON:0000982" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "skeletal joint" ; rdfs:subClassOf obo:UBERON_0004905, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004770 ], _:genid113177, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001434 ] ; owl:disjointWith obo:UBERON_0001474 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0002217 obo:UBERON_0011134 ) ] . obo:UBERON_0000983 obo:IAO_0000115 "A metapodium region that is part of a pes." ; obo:UBPROP_0000012 "mammalian and non-mammalian AOs differ in whether they consider this a part of the skeleton" ; oboInOwl:hasDbXref "CALOHA:TS-2221", "FMA:24997", "MA:0000049", "SCTID:280711000", "SCTID:370639003" ; oboInOwl:hasExactSynonym "hind metapodium", "metatarsal part of foot", "metatarsal region", "regio metatarsalis" ; oboInOwl:hasNarrowSynonym "hindlimb cannon region", "hindlimb equine cannon region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsus" ; oboInOwl:id "UBERON:0000983" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "metatarsus region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010545 ], _:genid113316 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009877 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0000985 obo:IAO_0000115 "Vein that drains the axilla." ; obo:UBPROP_0000008 "In human anatomy, the axillary vein is a large blood vessel that conveys blood from the lateral aspect of the thorax, axilla (armpit) and upper limb toward the heart. There is one axillary vein on each side of the body. Its origin is at the lower margin of the teres major muscle and a continuation of the brachial vein. Its tributaries include the basilic vein and cephalic vein, which are both superficial veins. It terminates at the lateral margin of the first rib, at which it becomes the subclavian vein. It is accompanied along its course by a similarly named artery, the axillary artery" ; oboInOwl:hasDbXref "EMAPA:18758", "FMA:13329", "GAID:527", "MA:0002084", "MESH:D001367", "NCIT:C32171", "SCTID:181389002", "UMLS:C0004456", "Wikipedia:Axillary_vein", "galen:AxillaryVein" ; oboInOwl:hasExactSynonym "vena axillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subcostal vein" ; oboInOwl:id "UBERON:0000985" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "axillary vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001587 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray576.png"^^xsd:anyURI . obo:UBERON_0000988 obo:IAO_0000115 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." ; obo:IAO_0000116 "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" ; obo:UBPROP_0000001 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" ; obo:UBPROP_0000003 "During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:PONS", "BAMS:Pons", "BIRNLEX:733", "BM:Pons", "BTO:0001101", "CALOHA:TS-0813", "DHBA:10661", "EFO:0001394", "EHDAA2:0004394", "EMAPA:17563", "EV:0100253", "FMA:67943", "GAID:578", "HBA:9131", "MA:0000204", "MAT:0000115", "MBA:771", "MESH:D011149", "MIAA:0000115", "NCIT:C12511", "SCTID:279103004", "UMLS:C0032639", "UMLS:C1280999", "VHOG:0001176", "Wikipedia:Pons", "neuronames:547" ; oboInOwl:hasExactSynonym "pons Varolii", "pons of Varolius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pons cerebri" ; oboInOwl:id "UBERON:0000988" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pons" ; rdfs:subClassOf obo:UBERON_0002616, _:genid113211, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001895 ], _:genid113213, _:genid113337 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png"^^xsd:anyURI . obo:UBERON_0000989 obo:IAO_0000115 "An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination." ; obo:UBPROP_0000007 "penile", "phallic" ; obo:UBPROP_0000008 "Most male birds (e.g., roosters and turkeys) have a cloaca (also present on the female), but not a penis. Among bird species with a penis are paleognathes (tinamous and ratites), Anatidae (ducks, geese and swans), and a very few other species (such as flamingoes). A bird penis is different in structure from mammal penises, being an erectile expansion of the cloacal wall and being erected by lymph, not blood. It is usually partially feathered and in some species features spines and brush-like filaments, and in flaccid state curls up inside the cloaca" ; oboInOwl:hasDbXref "BTO:0000405", "CALOHA:TS-0758", "EFO:0000987", "EHDAA2:0001433", "EHDAA:9380", "EMAPA:18682", "EMAPA_RETIRED:18996", "EV:0100107", "FMA:9707", "GAID:389", "MA:0000408", "MAT:0000186", "MESH:D010413", "MIAA:0000186", "NCIT:C12409", "SCTID:265793009", "UMLS:C0030851", "VHOG:0000727", "Wikipedia:Penis", "galen:Penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "penes", "phallus" ; oboInOwl:id "UBERON:0000989" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "penis" ; rdfs:subClassOf obo:UBERON_0008811, _:genid113351, _:genid113353 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/87/Labelled_flaccid_penis.jpg"^^xsd:anyURI . obo:UBERON_0000990 obo:IAO_0000115 "Anatomical system that has as its parts the organs concerned with reproduction." ; obo:IAO_0000116 "consider splitting genitalia from reproductive system" ; obo:UBPROP_0000001 "Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO]" ; obo:UBPROP_0000003 "Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG]" ; obo:UBPROP_0000202 obo:FMA_75572 ; dcterms:date "2022-06-10T18:22:34Z"^^xsd:dateTime ; oboInOwl:hasDbXref "AAO:0010258", "BILA:0000103", "BTO:0000081", "CALOHA:TS-1318", "EFO:0000809", "EHDAA2:0001603", "EHDAA:5923", "EMAPA:17381", "EV:0100100", "FBbt:00004857", "FMA:7160", "GAID:363", "HAO:0000374", "HAO:0000895", "MA:0000326", "MIAA:0000305", "NCIT:C12841", "SCTID:278875001", "TAO:0000632", "UMLS:C1261210", "VHOG:0000182", "WBbt:0005747", "Wikipedia:Reproductive_system", "XAO:0000142", "ZFA:0000632" ; oboInOwl:hasNarrowSynonym "genital system", "genitalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Geschlechtsorgan", "animal reproductive system", "genital tract", "organa genitalia", "reproductive tissue", "reproductive tract", "systemata genitalia" ; oboInOwl:id "UBERON:0000990" ; oboInOwl:inSubset core:efo_slim, core:functional_classification, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "reproductive system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000991 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001004, obo:UBERON_0001007, obo:UBERON_0001009, obo:UBERON_0001016, obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0000003 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg"^^xsd:anyURI . obo:UBERON_0000991 obo:IAO_0000115 "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." ; obo:UBPROP_0000001 "Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO]", "The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO]" ; obo:UBPROP_0000003 "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" ; obo:UBPROP_0000007 "gonadal" ; obo:UBPROP_0000012 "FMA xref is a 'general anatomical term'" ; oboInOwl:hasDbXref "AAO:0000213", "BILA:0000123", "BSA:0000079", "BTO:0000534", "EMAPA:17383", "FBbt:00004858", "FMA:18250", "GAID:368", "HAO:0000379", "MA:0002420", "MESH:D006066", "NCIT:C12725", "SCTID:304623008", "TAO:0000413", "UMLS:C0018067", "VHOG:0000397", "WBbt:0005175", "Wikipedia:Gonad", "XAO:0003146", "ZFA:0000413" ; oboInOwl:hasExactSynonym "gonada" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gonads" ; oboInOwl:id "UBERON:0000991" ; oboInOwl:inSubset core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "gonad" ; rdfs:subClassOf obo:UBERON_0003133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0007276 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005564 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000586 ] ) ] . obo:UBERON_0000992 obo:IAO_0000115 "The gonad of a female organism which contains germ cells." ; obo:UBPROP_0000001 "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]", "Female reproductive organ.[TAO]" ; obo:UBPROP_0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" ; obo:UBPROP_0000007 "ovarian" ; obo:UBPROP_0000008 "Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" ; oboInOwl:hasDbXref "AAO:0000371", "BILA:0000125", "BSA:0000080", "BTO:0000975", "CALOHA:TS-0730", "EFO:0000973", "EHDAA2:0001360", "EHDAA:8124", "EMAPA:17962", "EV:0100111", "FBbt:00004865", "FMA:7209", "GAID:367", "MA:0000384", "MESH:D010053", "MIAA:0000125", "NCIT:C12404", "SCTID:181464007", "TAO:0000403", "UMLS:C0029939", "VHOG:0000251", "Wikipedia:Ovary", "XAO:0000258", "ZFA:0000403" ; oboInOwl:hasExactSynonym "animal ovary", "female gonad", "female organism genitalia gonad", "female organism genitalia gonada", "female organism reproductive system gonad", "female organism reproductive system gonada", "female reproductive system gonad", "female reproductive system gonada", "genitalia of female organism gonad", "genitalia of female organism gonada", "gonad of female organism genitalia", "gonad of female organism reproductive system", "gonad of female reproductive system", "gonad of genitalia of female organism", "gonad of reproductive system of female organism", "gonada of female organism genitalia", "gonada of female organism reproductive system", "gonada of female reproductive system", "gonada of genitalia of female organism", "gonada of reproductive system of female organism", "ovum-producing ovary", "reproductive system of female organism gonad", "reproductive system of female organism gonada" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ovaries", "ovarium" ; oboInOwl:id "UBERON:0000992" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ovary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009117 ] ; owl:disjointWith obo:UBERON_0009117 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000991 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png"^^xsd:anyURI . obo:UBERON_0000993 obo:IAO_0000115 "A tube or collection of tubes in an animal from the ovaries to the outside of the body." ; obo:IAO_0000232 "sometimes oviduct is used interchangeably with follaopian tube. Here they are different - the oviduct connects the gonad to the outside in a variety of animals. The mammal-class fallopian tube is derived from the mullerian duct and connects the gonads/infubdibulum to the uterus" ; obo:UBPROP_0000001 "A passage through which ova leave the maternal body or pass to an organ communicating with the exterior of the body. [TFD][VHOG]" ; obo:UBPROP_0000003 "In all remaining vertebrates (i.e., coelacanths, lungfishes, amphibians, reptiles, birds, and mammals), the oviduct arises in ontogeny as a longitudinal, groovelike invagination of the coelomic epithelium on the lateral surface of the mesonephros.[well established][VHOG]" ; obo:UBPROP_0000008 "The only female vertebrates to lack oviducts are the jawless fishes. In these species, the single fused ovary releases eggs directly into the body cavity. The fish eventually extrudes the eggs through small genital pores towards the rear of the body[WP]", "in birds divided into infundibulum, magnum, isthmus, uterus, and vagina" ; oboInOwl:hasDbXref "AAO:0010533", "BSA:0000083", "BTO:0000980", "EFO:0000974", "EMAPA:18984", "GAID:366", "MAT:0000126", "MESH:D010057", "MIAA:0000126", "NCIT:C77957", "TAO:0000560", "UMLS:C0029954", "VHOG:0001136", "Wikipedia:Oviduct", "XAO:0003052", "ZFA:0000560" ; oboInOwl:hasExactSynonym "ovarian duct", "ovarian tube", "uterine tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "female reproductive tracts", "oviducts", "tuba uterina", "tuba uterinae", "tubular parts of female reproductive system" ; oboInOwl:id "UBERON:0000993" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "oviduct" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000992 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013514 ] . obo:UBERON_0000995 obo:IAO_0000115 "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." ; obo:UBPROP_0000001 "The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]" ; obo:UBPROP_0000003 "An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]" ; obo:UBPROP_0000007 "uterine" ; obo:UBPROP_0000008 "Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle 'vagina' which functions as the birth canal. Marsupial embryos form a choriovitelline 'placenta' (which can be thought of as something between a monotreme egg and a 'true' placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream." ; obo:UBPROP_0000011 "Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused [Wikipedia:Uterus]" ; oboInOwl:hasDbXref "BTO:0001424", "CALOHA:TS-1102", "EFO:0000975", "EMAPA:29915", "EV:0100113", "FMA:17558", "GAID:172", "MA:0000389", "MAT:0000127", "MESH:D014599", "MIAA:0000127", "NCIT:C12405", "SCTID:181452004", "UMLS:C0042149", "VHOG:0001137", "Wikipedia:Uterus", "galen:Uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0000995" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "uterus" ; rdfs:subClassOf obo:UBERON_0013515, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004175 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0005795 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png"^^xsd:anyURI . obo:UBERON_0000996 obo:IAO_0000115 "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." ; obo:UBPROP_0000001 "Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina.[FMA]", "The genital canal in the female, leading from the opening of the vulva to the cervix of the uterus. [TFD][VHOG]" ; obo:UBPROP_0000003 "The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.[well established][VHOG]" ; obo:UBPROP_0000007 "vaginal" ; obo:UBPROP_0000011 "'The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.' Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective, Third Edition (2001) Orlando Fla.: Harcourt College Publishers, p.688" ; oboInOwl:hasDbXref "BTO:0000243", "CALOHA:TS-1103", "EFO:0000976", "EMAPA:18986", "EV:0100117", "FMA:19949", "GAID:381", "MA:0000394", "MAT:0000128", "MESH:D014621", "MIAA:0000128", "NCIT:C12407", "SCTID:181441005", "UMLS:C0042232", "VHOG:0001138", "Wikipedia:Vagina", "galen:Vagina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal oviductal region", "distal portion of oviduct", "vaginae" ; oboInOwl:id "UBERON:0000996" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "vagina" ; rdfs:subClassOf obo:UBERON_0013515, _:genid113316, _:genid113446, _:genid113448 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Illu_repdt_female.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/a/a4/Vaginal_opening_-_english_description.jpg"^^xsd:anyURI . obo:UBERON_0000997 obo:IAO_0000115 "External genital organs of the female mammal[WP]." ; obo:UBPROP_0000001 "The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]" ; obo:UBPROP_0000007 "vulval" ; oboInOwl:hasDbXref "BTO:0003101", "CALOHA:TS-1168", "EFO:0000978", "EMAPA:36631", "EV:0100118", "FMA:20462", "GAID:383", "MA:0000395", "MAT:0000169", "MESH:D014844", "MIAA:0000169", "NCIT:C12408", "SCTID:265796001", "UMLS:C0042993", "VHOG:0001458", "Wikipedia:Vulva", "galen:Vulva" ; oboInOwl:hasExactSynonym "female pudendum", "mammalian vulva", "puboperineal region", "pudendum femininum", "vulva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pudendum", "pudendum femininum", "pudendum muliebre" ; oboInOwl:id "UBERON:0000997" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mammalian vulva" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005056 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg"^^xsd:anyURI . obo:UBERON_0000998 obo:IAO_0000115 "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." ; obo:UBPROP_0000001 "Either of a pair of pouchlike glands situated on each side of the male urinary bladder that secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra. [TFD][VHOG]" ; obo:UBPROP_0000003 "(In mammalian testis) Along the way (the sperm travel), three accessory sex glands, the seminal vesicle, prostate, and bulbourethral (Cowper's) gland, respectively, add their secretions as sperm move from the testes to the urethra.[well established][VHOG]" ; obo:UBPROP_0000009 "The seminal vesicles secrete a significant proportion of the fluid that ultimately becomes semen. Lipofuscin granules from dead epithelial cells give the secretion its yellowish color. About 50-70% of the seminal fluid in humans originates from the seminal vesicles, but is not expelled in the first ejaculate fractions which are dominated by spermatozoa and zinc-rich prostatic fluid." ; oboInOwl:hasBroadSynonym "seminal gland" ; oboInOwl:hasDbXref "AAO:0010788", "BTO:0001234", "CALOHA:TS-0919", "EFO:0000986", "EMAPA:19180", "EV:0100106", "FMA:19386", "GAID:394", "MA:0000410", "MAT:0000171", "MESH:D012669", "MIAA:0000171", "NCIT:C12787", "SCTID:181434004", "UMLS:C0036628", "VHOG:0001379", "Wikipedia:Seminal_vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula seminalis", "glandula vesiculosa", "gonecyst", "vas efferens", "vesicula seminalis", "vesiculae seminales", "vesicular gland", "vesicular glands", "vesicular seminalis", "vesiculæ seminales" ; oboInOwl:id "UBERON:0000998" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "seminal vesicle" ; rdfs:subClassOf obo:UBERON_0006868, _:genid113337, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000080 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004054 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0010143 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg"^^xsd:anyURI . obo:UBERON_0000999 obo:IAO_0000115 "The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0001580", "CALOHA:TS-0211", "EFO:0000985", "EMAPA:19088", "FMA:19325", "GAID:388", "MA:0003247", "MAT:0000170", "MESH:D004543", "MIAA:0000170", "NCIT:C32493", "SCTID:279665005", "UMLS:C0013747", "Wikipedia:Ejaculatory_duct" ; oboInOwl:hasExactSynonym "ductus ejaculatorii", "ductus ejaculatorius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus ejaculatorii" ; oboInOwl:id "UBERON:0000999" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ejaculatory duct" ; rdfs:subClassOf obo:UBERON_0000058, _:genid113353, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000079 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0042713 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001968 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0010143 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0000998 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001000 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0000057 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png"^^xsd:anyURI . obo:UBERON_0001000 obo:IAO_0000115 "A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct." ; obo:UBPROP_0000003 "The continuation of the archinephric duct, now called the deferent duct, extends caudally to the cloaca or to the part of the mammalian urethra that is derived from the cloaca.[well established][VHOG]" ; obo:UBPROP_0000008 "Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm is carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans. In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species. In amniotes, however, the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm. The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall." ; oboInOwl:hasDbXref "BTO:0001427", "CALOHA:TS-1105", "EFO:0000981", "EMAPA:18681", "EV:0100105", "FMA:19234", "GAID:404", "MA:0000413", "MESH:D014649", "MIAA:0000129", "NCIT:C12813", "SCTID:245467009", "UMLS:C0042360", "VHOG:0001135", "Wikipedia:Vas_deferens", "galen:VasDeferens" ; oboInOwl:hasExactSynonym "deferent duct", "ductus deferens", "vas deferen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sperm duct", "vasa deferentia" ; oboInOwl:id "UBERON:0001000" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vas deferens" ; rdfs:subClassOf obo:UBERON_0000058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006947 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004054 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001968 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001301 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0000999 ], _:genid113497 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg"^^xsd:anyURI . obo:UBERON_0001003 obo:IAO_0000115 "The outer epithelial layer of the skin that is superficial to the dermis." ; obo:UBPROP_0000001 "A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]", "The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass external integument structures (AAO:0000961)[AAO]" ; obo:UBPROP_0000003 "(...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]" ; obo:UBPROP_0000007 "epidermal" ; obo:UBPROP_0000008 "Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes)." ; oboInOwl:hasBroadSynonym "epidermis", "skin" ; oboInOwl:hasDbXref "AAO:0000143", "BTO:0000404", "CALOHA:TS-0283", "EFO:0000954", "EMAPA:17528", "EV:0100153", "FMA:70596", "GAID:932", "MA:0000153", "MAT:0000154", "MESH:D004817", "MIAA:0000154", "NCIT:C12708", "SCTID:361694003", "TAO:0000105", "UMLS:C0014520", "VHOG:0000077", "Wikipedia:Epidermis_(skin)", "XAO:0000028", "ZFA:0000105" ; oboInOwl:hasExactSynonym "vertebrate epidermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001003" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "skin epidermis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002067 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0003055 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] . obo:UBERON_0001004 obo:IAO_0000115 "Functional system which consists of structures involved in respiration." ; obo:RO_0002161 obo:NCBITaxon_147099 ; obo:UBPROP_0000001 "The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]" ; obo:UBPROP_0000003 "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000541", "BTO:0000203", "CALOHA:TS-1319", "EFO:0000804", "EHDAA2:0001604", "EHDAA:2203", "EMAPA:16727", "EV:0100036", "FMA:7158", "GAID:78", "MA:0000327", "MAT:0000030", "MESH:D012137", "MIAA:0000030", "NCIT:C12779", "SCTID:278197002", "TAO:0000272", "UMLS:C0035237", "VHOG:0000202", "Wikipedia:Respiratory_system", "XAO:0000117", "ZFA:0000272" ; oboInOwl:hasExactSynonym "apparatus respiratorius", "respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Atmungssystem", "apparatus respiratorius", "systema respiratorium" ; oboInOwl:id "UBERON:0001004" ; oboInOwl:inSubset core:efo_slim, core:functional_classification, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "respiratory system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001007, obo:UBERON_0001009, obo:UBERON_0001016, obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007585 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg"^^xsd:anyURI . obo:UBERON_0001005 obo:IAO_0000115 "An airway through which respiratory air passes in organisms." ; obo:IAO_0000232 "This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends" ; oboInOwl:hasBroadSynonym "airway", "airways" ; oboInOwl:hasDbXref "FMA:265130", "SCTID:361380005", "Wikipedia:Trachea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001005" ; oboInOwl:inSubset core:grouping_class, core:uberon_slim ; a owl:Class ; rdfs:label "respiratory airway" ; rdfs:subClassOf obo:UBERON_0003103, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0034874 ] . obo:UBERON_0001007 obo:IAO_0000115 "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." ; obo:UBPROP_0000001 "An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]" ; obo:UBPROP_0000007 "digestive" ; obo:UBPROP_0000012 "many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class" ; oboInOwl:hasDbXref "AAO:0000129", "BILA:0000082", "BTO:0000058", "CALOHA:TS-1293", "EFO:0000793", "EV:0100056", "FBbt:00005055", "FMA:7152", "GAID:278", "MA:0002431", "MAT:0000018", "MESH:D004064", "MIAA:0000018", "SCTID:278859004", "TADS:0000170", "TAO:0000339", "WBbt:0005748", "Wikipedia:Digestive_system", "XAO:0000125", "ZFA:0000339", "galen:DigestiveSystem", "ncithesaurus:Digestive_System" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alimentary system", "alimentary tract", "gastrointestinal system", "gut" ; oboInOwl:id "UBERON:0001007" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "digestive system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001009, obo:UBERON_0001016, obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0022600 ] ) ] . obo:UBERON_0001008 obo:IAO_0000115 "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." ; obo:IAO_0000116 "In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here" ; obo:RO_0002161 obo:NCBITaxon_110815, obo:NCBITaxon_147099 ; obo:UBPROP_0000001 "An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO]" ; obo:UBPROP_0000003 "Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels", "This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans" ; oboInOwl:hasBroadSynonym "excretory system" ; oboInOwl:hasDbXref "AAO:0010257", "BILA:0000015", "BTO:0001244", "BTO:0003092", "CALOHA:TS-1323", "EFO:0000803", "EHDAA2:0001601", "EHDAA:5901", "EMAPA:17366", "EV:0100095", "FBbt:00005056", "FMA:7159", "GAID:391", "MA:0000325", "MAT:0000027", "MESH:D014551", "MIAA:0000027", "NCIT:C12413", "SCTID:362204003", "TADS:0000162", "TAO:0000163", "UMLS:C1508753", "VHOG:0000723", "WBbt:0005736", "Wikipedia:Excretory_system", "XAO:0000143", "ZFA:0000163", "galen:UrinaryTract" ; oboInOwl:hasExactSynonym "systema urinaria", "systema urinarium", "urinary system", "urinary tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renal or urinary system", "renal/urinary system" ; oboInOwl:id "UBERON:0001008" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "renal system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_8450002 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0097254 ] ) ] . obo:UBERON_0001009 obo:IAO_0000115 "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." ; obo:IAO_0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" ; obo:RO_0002161 obo:NCBITaxon_147099 ; obo:UBPROP_0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" ; obo:UBPROP_0000003 "We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000959", "CALOHA:TS-2103", "VHOG:0001248", "Wikipedia:Circulatory_system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "systema cardiovasculare" ; oboInOwl:id "UBERON:0001009" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "circulatory system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001016, obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg"^^xsd:anyURI . obo:UBERON_0001010 obo:IAO_0000115 "The body of the ulna at its upper part is prismatic in form, and curved so as to be convex behind and lateralward; its central part is straight; its lower part is rounded, smooth, and bent a little lateralward. It tapers gradually from above downward, and has three borders and three surfaces." ; oboInOwl:hasDbXref "FMA:33760", "NCIT:C120676", "SCTID:302520004", "Wikipedia:Body_of_ulna" ; oboInOwl:hasExactSynonym "body of ulna", "corpus ulnae", "shaft of ulna", "ulnar diaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "shaft of ulna", "supinator crest" ; oboInOwl:id "UBERON:0001010" ; a owl:Class ; rdfs:label "diaphysis of ulna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0001012 obo:IAO_0000115 "The head of the radius has a cylindrical form, and on its upper surface is a shallow cup or fovea for articulation with the capitulum (or capitellum) of the humerus. The circumference of the head is smooth; it is broad medially where it articulates with the radial notch of the ulna, narrow in the rest of its extent, which is embraced by the annular ligament. The deepest point in the fovea is not axi-symmetric with the long axis of the radius, creating a cam effect during pronation and supination[WP]." ; oboInOwl:hasDbXref "FMA:33773", "SCTID:181941003", "Wikipedia:Head_of_radius", "galen:HeadOfRadius" ; oboInOwl:hasExactSynonym "radial head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caput radii" ; oboInOwl:id "UBERON:0001012" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "head of radius" ; rdfs:subClassOf obo:UBERON_0005913, _:genid113583, _:genid113585 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/47/Gray214.png"^^xsd:anyURI . obo:UBERON_0001013 obo:IAO_0000115 "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." ; obo:UBPROP_0000001 "Connective tissue in which fat is stored.[TAO]", "Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" ; obo:UBPROP_0000003 "Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]" ; obo:UBPROP_0000007 "adipose" ; obo:UBPROP_0000008 "In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen." ; obo:UBPROP_0000012 "in FMA this is dense irregular connective tissue" ; oboInOwl:hasDbXref "AAO:0000001", "AEO:000020", "BTO:0001487", "CALOHA:TS-0013", "EFO:0000790", "EHDAA2:0003120", "EMAPA:35112", "EV:0100381", "FMA:20110", "GAID:920", "MA:0000009", "MAT:0000015", "MESH:D000273", "MIAA:0000015", "NCIT:C12472", "SCTID:55603005", "TAO:0002134", "UMLS:C0001527", "VHOG:0001284", "Wikipedia:Adipose_tissue", "XAO:0003049", "ZFA:0005345", "galen:FattyTissue" ; oboInOwl:hasExactSynonym "fat", "fat tissue", "fatty tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adipose", "bodyfat", "fatty depot" ; oboInOwl:id "UBERON:0001013" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "adipose tissue" ; rdfs:subClassOf obo:UBERON_0011822 ; owl:disjointWith obo:UBERON_0003714 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000136 ] ) ] . obo:UBERON_0001015 obo:IAO_0000115 "A subdivision of the muscular system corresponding to a subdisivision of an organism." ; obo:RO_0002171 obo:UBERON_0001474 ; obo:UBPROP_0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." ; oboInOwl:hasDbXref "AAO:0011066", "BTO:0000887", "EFO:0001949", "EMAPA:32715", "EMAPA:35577", "FMA:32558", "MA:0000165", "NCIT:C13056", "TAO:0000548", "UMLS:C0026845", "VSAO:0005038", "WBbt:0005737", "Wikipedia:Muscular_system", "ZFA:0000548" ; oboInOwl:hasExactSynonym "muscle group", "muscles set", "musculature", "musculi", "set of muscles", "set of skeletal muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle system", "muscles", "musculature system" ; oboInOwl:id "UBERON:0001015" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "musculature" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000383 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001630 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png"^^xsd:anyURI . obo:UBERON_0001016 obo:IAO_0000115 "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." ; obo:RO_0002161 obo:NCBITaxon_6040 ; obo:UBPROP_0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]", "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" ; obo:UBPROP_0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" ; obo:UBPROP_0000007 "nervous", "neural" ; oboInOwl:hasDbXref "AAO:0000324", "BILA:0000079", "BIRNLEX:844", "BTO:0001484", "CALOHA:TS-1313", "EFO:0000802", "EHDAA2:0001246", "EHDAA:826", "EMAPA:16469", "EV:0100162", "FBbt:00005093", "FMA:7157", "GAID:466", "MA:0000016", "MAT:0000026", "MESH:D009420", "MIAA:0000026", "NCIT:C12755", "SCTID:278196006", "TAO:0000396", "UMLS:C0027763", "VHOG:0000402", "WBbt:0005735", "Wikipedia:Nervous_system", "XAO:0000177", "ZFA:0000396", "neuronames:3236" ; oboInOwl:hasExactSynonym "neurological system" ; oboInOwl:hasNarrowSynonym "nerve net" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "systema nervosum" ; oboInOwl:id "UBERON:0001016" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nervous system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000540 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050877 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid113617 ; owl:disjointWith obo:UBERON_0001033, obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png"^^xsd:anyURI . obo:UBERON_0001017 obo:IAO_0000115 "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." ; obo:RO_0002161 obo:NCBITaxon_147099 ; obo:UBPROP_0000001 "Part of the nervous system which includes the brain and spinal cord.[AAO]", "The brain and spinal cord. Kimmel et al, 1995.[TAO]", "The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO)." ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000090", "BAMS:CNS", "BILA:0000080", "BIRNLEX:1099", "BTO:0000227", "CALOHA:TS-0150", "EFO:0000908", "EHDAA2:0000225", "EHDAA:828", "EMAPA:16470", "EMAPA:16754", "EV:0100163", "FBbt:00005094", "FMA:55675", "GAID:570", "MA:0000167", "MAT:0000457", "MESH:D002490", "NCIT:C12438", "SCTID:278199004", "TAO:0000012", "UMLS:C0927232", "VHOG:0000293", "Wikipedia:Central_nervous_system", "XAO:0000215", "ZFA:0000012", "neuronames:854" ; oboInOwl:hasExactSynonym "CNS", "systema nervosum centrale" ; oboInOwl:hasNarrowSynonym "cerebrospinal axis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neuraxis" ; oboInOwl:id "UBERON:0001017" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "central nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ], _:genid113629 . obo:UBERON_0001018 obo:IAO_0000115 "A group of axons linking two or more neuropils and having a common origin, termination[FBbt]." ; obo:UBPROP_0000001 "White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. (CUMBO)" ; oboInOwl:hasDbXref "BIRNLEX:1649", "EV:0100304", "FBbt:00005100", "FMA:83847", "NLX:147822" ; oboInOwl:hasExactSynonym "axonal tract", "neuraxis tract", "tract of neuraxis" ; oboInOwl:hasNarrowSynonym "nerve tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nerve tract", "tract" ; oboInOwl:id "UBERON:0001018" ; oboInOwl:inSubset core:cumbo, core:pheno_slim ; a owl:Class ; rdfs:comment "WP says this is the analog of peripheral nerves in CNS." ; rdfs:label "axon tract" ; rdfs:subClassOf obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] . obo:UBERON_0001019 obo:IAO_0000115 "A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed)." ; obo:IAO_0000116 "note FBbt class not disjoint from tract. Consider merging with 'neuron projection bundle'" ; oboInOwl:hasBroadSynonym "fascicle" ; oboInOwl:hasDbXref "BIRNLEX:872", "BTO:0002191", "EMAPA:36605", "FMA:12235", "NCIT:C32586", "TGMA:0000088", "UMLS:C1185741", "Wikipedia:Nervous_system_fascicle" ; oboInOwl:hasExactSynonym "fasciculus", "nerve bundle", "nerve fasciculus", "neural fasciculus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nerve fiber tract" ; oboInOwl:id "UBERON:0001019" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "nerve fasciculus" ; rdfs:subClassOf obo:UBERON_0000122 . obo:UBERON_0001020 obo:IAO_0000115 "Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt]." ; obo:UBPROP_0000001 "White matter fiber bundle that crosses the midline of the brain or spinal cord, that connects similar structures on both sides. (CUMBO; Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)" ; obo:UBPROP_0000007 "commissural" ; oboInOwl:hasBroadSynonym "commissure" ; oboInOwl:hasDbXref "FMA:83906", "NCIT:C32349", "NLX:110", "NLXANAT:20090513", "TADS:0000201", "UMLS:C1185742", "Wikipedia:Commissure" ; oboInOwl:hasExactSynonym "commissure of neuraxis", "neuraxis commissure" ; oboInOwl:hasNarrowSynonym "white matter commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001020" ; oboInOwl:inSubset core:cumbo, core:uberon_slim ; a owl:Class ; rdfs:comment "*not* the same as FMA:76741 Commissure" ; rdfs:label "nervous system commissure" ; rdfs:subClassOf obo:UBERON_0001018, [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0001021 obo:IAO_0000115 "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." ; obo:UBPROP_0000001 "A portion of tissue which is a fasiculated group of axons.[TAO]" ; obo:UBPROP_0000007 "nervous" ; oboInOwl:hasDbXref "AAO:0011070", "AEO:0000137", "BAMS:n", "BIRNLEX:1615", "BSA:0000098", "BTO:0000925", "BTO:0001027", "CALOHA:TS-0772", "EHDAA2:0003137", "EHDAA:2851", "EHDAA:3776", "EHDAA:4657", "EMAPA:32808", "EMAPA:32815", "EV:0100371", "FBbt:00005105", "FMA:65132", "FMA:65239", "GAID:747", "GAID:758", "MA:0000217", "MA:0000228", "MESH:D010525", "NCIT:C12466", "NCIT:C12768", "NLX:147826", "SCTID:244457007", "SCTID:256864008", "TAO:0007009", "UMLS:C0027740", "UMLS:C0031119", "VHOG:0000901", "Wikipedia:Nervous_system", "XAO:0000204", "XAO:0003047", "ZFA:0007009", "galen:Nerve" ; oboInOwl:hasExactSynonym "nerves", "peripheral nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural subtree" ; oboInOwl:id "UBERON:0001021" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nerve" ; rdfs:subClassOf obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002045 ] . obo:UBERON_0001027 obo:IAO_0000115 "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." ; oboInOwl:hasDbXref "AEO:0000201", "EHDAA2:0003200", "FBbt:00005136", "FMA:5868", "Wikipedia:Sensory_nerve" ; oboInOwl:hasExactSynonym "nervus sensorius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "afferent nerve" ; oboInOwl:id "UBERON:0001027" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sensory nerve" ; rdfs:subClassOf obo:UBERON_0001021, _:genid113673 . obo:UBERON_0001028 obo:IAO_0000115 "A diaphysis that is part of a radius bone[Automatically generated definition]." ; obo:UBPROP_0000001 "The body of the radius (or shaft of radius) is prismoid in form, narrower above than below, and slightly curved, so as to be convex lateralward. It presents three borders and three surfaces[Wikipedia:Body_of_radius]." ; oboInOwl:hasDbXref "FMA:33782", "NCIT:C120674", "SCTID:302518002", "Wikipedia:Body_of_radius" ; oboInOwl:hasExactSynonym "body of radius", "corpus radii", "radial diaphysis", "shaft of radius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "radial shaft", "shaft of radius" ; oboInOwl:id "UBERON:0001028" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "diaphysis of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0001032 obo:IAO_0000115 "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." ; obo:UBPROP_0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" ; obo:UBPROP_0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" ; oboInOwl:hasDbXref "AAO:0000555", "BAMS:SEN", "BILA:0000099", "EFO:0000805", "EHDAA2:0003094", "EMAPA:16192", "FBbt:00007692", "FMA:75259", "MA:0002442", "MAT:0000031", "MIAA:0000031", "NLXANAT:090816", "TAO:0000282", "VHOG:0001674", "Wikipedia:Sensory_system", "XAO:0003194", "ZFA:0000282" ; oboInOwl:hasExactSynonym "organa sensuum", "sense organ subsystem", "sense organs", "sense organs set", "sensory subsystem", "sensory systems" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organa sensuum", "sensory organ system", "set of sense organs" ; oboInOwl:id "UBERON:0001032" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "sensory system" ; rdfs:subClassOf obo:UBERON_0015203, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007600 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png"^^xsd:anyURI . obo:UBERON_0001033 obo:IAO_0000115 "The sensory system for the sense of taste." ; obo:UBPROP_0000001 "The sensory system for the sense of taste[NLXANAT:090803].", "The sensory system used for the sense of taste.[AAO]" ; obo:UBPROP_0000007 "gustatory" ; obo:UBPROP_0000012 "in ZFA and MA this is a subtype of sensory system. we should change sensory system to disambiguate parts and wholes" ; oboInOwl:hasDbXref "AAO:0010577", "BILA:0000143", "EFO:0000830", "FMA:7194", "MA:0002446", "MAT:0000275", "MIAA:0000275", "NLXANAT:090803", "SCTID:423940004", "TAO:0001101", "Wikipedia:Gustatory_system", "XAO:0003197", "ZFA:0001101", "neuronames:2889" ; oboInOwl:hasExactSynonym "gustatory organ system", "taste system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001033" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "gustatory system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001434, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0050912 ] ) ] . obo:UBERON_0001037 obo:IAO_0000115 "A filament, mostly protein, that grows from follicles found in the dermis[WP]." ; obo:IAO_0000116 "TODO for now we treat vibrissa/whisker as a syonym, but these have different follicles. We could introduce subclasses (see also: Pangolin scales)" ; obo:IAO_0000232 "this class defines an individual hair" ; oboInOwl:hasDbXref "BTO:0001501", "CALOHA:TS-0430", "EFO:0000958", "EMAPA:18769", "EV:0100157", "FMA:53667", "GAID:71", "MA:0000155", "MAT:0000160", "MESH:D006197", "MIAA:0000160", "NCIT:C32705", "SCTID:361702001", "UMLS:C0018494", "VHOG:0001191", "Wikipedia:Hair" ; oboInOwl:hasExactSynonym "hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coat hair", "coat/ hair", "fur", "microchaeta", "quill", "setulae", "vibrissa", "whisker" ; oboInOwl:id "UBERON:0001037" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "strand of hair" ; rdfs:subClassOf obo:UBERON_0000021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0045095 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002073 ], _:genid113710, _:genid113712 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Gray945.png"^^xsd:anyURI . obo:UBERON_0001040 obo:IAO_0000115 "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." ; obo:IAO_0000116 "consider splitting class" ; obo:UBPROP_0000001 "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]", "the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" ; obo:UBPROP_0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" ; obo:UBPROP_0000008 "In therians, a structure homologous to the yolk sac is is present, but contains no yolk platelets. Instead it is filled with fluid [ISBN:0073040584 (Vertebrates, Kardong)]" ; oboInOwl:hasDbXref "BTO:0001471", "CALOHA:TS-1130", "EFO:0003078", "EHDAA2:0002212", "EHDAA:164", "EMAPA:16085", "FMA:87180", "GAID:1301", "MESH:D015017", "NCIT:C14128", "SCTID:362845002", "UMLS:C0043425", "VHOG:0000830", "Wikipedia:Yolk_sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "saccus vitellinus", "vesicula umbilicalis" ; oboInOwl:id "UBERON:0001040" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "yolk sac" ; rdfs:subClassOf obo:UBERON_0005631, obo:UBERON_0007499, _:genid113723, _:genid113725 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png"^^xsd:anyURI . obo:UBERON_0001041 obo:IAO_0000115 "Anterior subdivision of a digestive tract." ; obo:IAO_0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure" ; obo:UBPROP_0000001 "The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder." ; obo:UBPROP_0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011042", "BILA:0000085", "BTO:0000507", "EHDAA2:0000557", "EHDAA:520", "EMAPA:16548", "FBbt:00005379", "FMA:45616", "MA:0001526", "NCIT:C34180", "SCTID:361409009", "TGMA:0001014", "UMLS:C0231051", "VHOG:0000285", "Wikipedia:Foregut", "XAO:0000232" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "praeenteron", "proenteron" ; oboInOwl:id "UBERON:0001041" ; oboInOwl:inSubset core:developmental_classification, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "foregut" ; rdfs:subClassOf obo:UBERON_0004921 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png"^^xsd:anyURI . obo:UBERON_0001042 obo:IAO_0000115 "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." ; obo:UBPROP_0000001 "A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867].", "Anatomical cavity bounded by the derivatives of the branchial arches.[AAO]", "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO]", "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576].", "The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000002 "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO]", "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO]" ; obo:UBPROP_0000003 "(...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG]" ; obo:UBPROP_0000012 "MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme" ; oboInOwl:hasBroadSynonym "pharynx" ; oboInOwl:hasDbXref "AAO:0000967", "BTO:0001049", "CALOHA:TS-0785", "EFO:0000836", "EHDAA2:0001458", "EHDAA:2947", "EMAPA:16706", "EV:0100065", "FMA:46688", "GAID:155", "MA:0000432", "MESH:D010614", "NCIT:C12425", "SCTID:181211006", "TAO:0000056", "UMLS:C0031354", "VHOG:0000462", "Wikipedia:Pharynx", "XAO:0003227", "ZFA:0000056", "galen:Pharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001042" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Consider generalizing to deuterostome pharynx" ; rdfs:label "chordate pharynx" ; rdfs:subClassOf obo:UBERON_0006562, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], _:genid113741 . obo:UBERON_0001043 obo:IAO_0000115 "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." ; obo:UBPROP_0000001 "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" ; obo:UBPROP_0000003 "The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]" ; obo:UBPROP_0000007 "esophageal" ; obo:UBPROP_0000012 "esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)" ; oboInOwl:hasDbXref "AAO:0000145", "ANISEED:1235301", "BTO:0000959", "CALOHA:TS-0700", "EFO:0000835", "EHDAA2:0001285", "EHDAA:2937", "EMAPA:16833", "EV:0100069", "FMA:7131", "GAID:291", "MA:0000352", "MAT:0000048", "MESH:D004947", "MIAA:0000048", "NCIT:C12389", "SCTID:181245004", "TAO:0000204", "UMLS:C0014876", "VHOG:0000450", "Wikipedia:Esophagus", "XAO:0000127", "ZFA:0000204", "galen:Esophagus" ; oboInOwl:hasExactSynonym "gullet", "oesophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001043" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "esophagus" ; rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004908 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001042 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg"^^xsd:anyURI . obo:UBERON_0001044 obo:IAO_0000115 "Saliva-secreting exocrine glands of the oral cavity[GO]." ; obo:IAO_0000232 "currently we define saliva and salivary glands very generally in functional terms but it may be more appropriate to split this class. From WP: In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals." ; obo:UBPROP_0000001 "A gland that produces the saliva. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "In air-feeding animals, the lack of water column to lubricate the food has been compensated for by the evolution of the salivary glands. These glands are present only in amniotes and are controlled by the parasympathetic system.[well established][VHOG]" ; obo:UBPROP_0000008 "The salivary glands in mammals are exocrine glands, glands with ducts, that produce saliva. They also secrete amylase, an enzyme that breaks down starch into maltose. In other organisms such as insects, salivary glands are often used to produce biologically important proteins like silk or glues, and fly salivary glands contain polytene chromosomes that have been useful in genetic research. The salivary glands of some species are modified to produce enzymes; salivary amylase is found in many, but by no means all, bird and mammal species (including humans, as noted above). Furthermore, the venom glands of poisonous snakes, Gila monsters, and some shrews, are modified salivary glands" ; oboInOwl:hasDbXref "BTO:0001203", "CALOHA:TS-0892", "EFO:0000859", "EHDAA2:0001775", "EHDAA:7987", "EMAPA:17751", "EV:0100059", "FBbt:00005382", "FMA:9597", "GAID:937", "MA:0000346", "MAT:0000079", "MESH:D012469", "MIAA:0000079", "NCIT:C12426", "SCTID:181236000", "UMLS:C0036098", "VHOG:0000376", "Wikipedia:Salivary_gland", "galen:SalivaryGland" ; oboInOwl:hasExactSynonym "salivary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandulae salivariae" ; oboInOwl:id "UBERON:0001044" ; oboInOwl:inSubset core:efo_slim, core:functional_classification, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "saliva-secreting gland" ; rdfs:subClassOf obo:UBERON_0010047, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000167 ], _:genid113629, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001836 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg"^^xsd:anyURI . obo:UBERON_0001045 obo:IAO_0000115 "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." ; obo:IAO_0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. We may explicitly make this a developmental class" ; obo:UBPROP_0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" ; obo:UBPROP_0000008 "In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon" ; obo:UBPROP_0000012 "in FMA this represents an embryonic region." ; oboInOwl:hasDbXref "BILA:0000086", "BTO:0000863", "EFO:0001950", "EHDAA2:0001185", "EHDAA:983", "EMAPA:16255", "FBbt:00005383", "FMA:45617", "MA:0001564", "NCIT:C34210", "SCTID:361410004", "TGMA:0001036", "UMLS:C0231052", "VHOG:0000290", "Wikipedia:Midgut", "XAO:0000103" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesenteron" ; oboInOwl:id "UBERON:0001045" ; oboInOwl:inSubset core:developmental_classification, core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "midgut" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001041 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg"^^xsd:anyURI . obo:UBERON_0001046 obo:IAO_0000115 "The caudalmost subdivision of a digestive tract." ; obo:IAO_0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future (vertebrates have some contribution from NC - https://github.com/obophenotype/uberon/wiki/The-neural-crest). We may explicitly make this a developmental class" ; obo:UBPROP_0000001 "the caudal portion of the primitive digestive tube of the embryo" ; obo:UBPROP_0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "in FMA this class has no children. In MA it has a single child hindgut epithelium" ; oboInOwl:hasDbXref "AAO:0011052", "BILA:0000087", "BTO:0000510", "EHDAA2:0000779", "EHDAA:975", "EMAPA:16715", "FBbt:00005384", "FMA:45618", "MA:0001527", "NCIT:C34188", "SCTID:362856002", "TGMA:0001020", "UMLS:C0231053", "VHOG:0000459", "Wikipedia:Hindgut", "XAO:0000104" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metenteron" ; oboInOwl:id "UBERON:0001046" ; oboInOwl:inSubset core:developmental_classification, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hindgut" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001045 ], _:genid113787 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png"^^xsd:anyURI . obo:UBERON_0001048 obo:IAO_0000115 "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." ; oboInOwl:hasDbXref "AEO:0000171", "BTO:0001886", "EFO:0001652", "EHDAA2:0003171", "FBbt:00005495", "FMA:86589", "MAT:0000482", "NCIT:C34275", "UMLS:C0678727", "Wikipedia:Primordium", "XAO:0003043" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bud", "future organ", "placode", "primordia", "rudiment" ; oboInOwl:id "UBERON:0001048" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "primordium" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] . obo:UBERON_0001049 obo:IAO_0000115 "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." ; obo:UBPROP_0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]", "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; obo:UBPROP_0000011 "The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium" ; oboInOwl:hasDbXref "AAO:0010617", "BTO:0001057", "CALOHA:TS-2371", "DHBA:10154", "EHDAA2:0001254", "EHDAA:2869", "EHDAA:908", "EMAPA:16164", "EMAPA:16757", "FMA:293882", "MAT:0000069", "MESH:D054259", "MIAA:0000069", "NCIT:C34226", "SCTID:362852000", "TAO:0001135", "UMLS:C0231024", "VHOG:0000307", "Wikipedia:Neural_tube", "XAO:0003204", "ZFA:0001135", "neuronames:1365" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural primordium", "presumptive central nervous system", "tubus neuralis" ; oboInOwl:id "UBERON:0001049" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neural tube" ; rdfs:subClassOf obo:UBERON_0003914, obo:UBERON_0016879, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005068 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0001051 obo:IAO_0000115 "Bottom part of the pharynx that connects to the esophagus." ; obo:UBPROP_0000001 "The inferior portion of the pharynx, between the epiglottis and the larynx. [TFD][VHOG]" ; obo:UBPROP_0000007 "hypopharyngeal" ; oboInOwl:hasDbXref "BTO:0001740", "CALOHA:TS-2020", "EFO:0001388", "EHDAA2:0004574", "EV:0100068", "FMA:54880", "GAID:338", "MA:0001796", "MESH:D007013", "NCIT:C12246", "SCTID:281490009", "UMLS:C0020629", "VHOG:0000445", "Wikipedia:Hypopharynx" ; oboInOwl:hasExactSynonym "laryngeal pharynx", "laryngopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pars laryngea pharyngis" ; oboInOwl:id "UBERON:0001051" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hypopharynx" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0013472 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001042 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg"^^xsd:anyURI . obo:UBERON_0001052 obo:IAO_0000115 "The terminal portion of the intestinal tube, terminating with the anus." ; obo:UBPROP_0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000007 "rectal" ; obo:UBPROP_0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" ; oboInOwl:hasDbXref "AAO:0010401", "BTO:0001158", "CALOHA:TS-1180", "EFO:0000848", "EHDAA2:0001592", "EHDAA:5836", "EMAPA:17896", "EV:0100081", "FMA:14544", "GAID:311", "MA:0000336", "MAT:0000050", "MESH:D012007", "MIAA:0000050", "NCIT:C12390", "SCTID:181261002", "UMLS:C0034896", "VHOG:0001751", "Wikipedia:Rectum", "XAO:0000238", "galen:Rectum" ; oboInOwl:hasExactSynonym "terminal portion of intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinum rectum", "rectal sac", "terminal portion of large intestine" ; oboInOwl:id "UBERON:0001052" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "rectum" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006866 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001159 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000059 ], _:genid113821, _:genid113824, _:genid113826 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif"^^xsd:anyURI . obo:UBERON_0001062 obo:IAO_0000115 "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010841", "AEO:0000000", "BILA:0000000", "BIRNLEX:6", "CARO:0000000", "EHDAA2:0002229", "FBbt:10000000", "FMA:62955", "HAO:0000000", "MA:0000001", "NCIT:C12219", "TAO:0100000", "TGMA:0001822", "UMLS:C1515976", "WBbt:0000100", "XAO:0000000", "ZFA:0100000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001062" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical entity" . obo:UBERON_0001064 obo:IAO_0000115 "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." ; obo:IAO_0000116 "in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue" ; obo:UBPROP_0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" ; obo:UBPROP_0000011 "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." ; oboInOwl:hasAlternativeId "UBERON:0005627" ; oboInOwl:hasBroadSynonym "pancreatic duct" ; oboInOwl:hasDbXref "BTO:0002362", "EHDAA2:0001396", "EHDAA:6905", "EMAPA:17510", "FMA:16003", "GAID:337", "MA:0000126", "MESH:D010183", "NCIT:C12272", "RETIRED_EHDAA2:0002177", "SCTID:245385001", "UMLS:C0030288", "VHOG:0000256", "Wikipedia:Pancreatic_duct" ; oboInOwl:hasExactSynonym "chief pancreatic duct", "duct of Wirsung", "main pancreatic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canal of Wirsung", "ductus pancreatis ventralis", "hepaticopancreatic duct" ; oboInOwl:id "UBERON:0001064" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "ventral pancreatic duct" ; rdfs:subClassOf obo:UBERON_0007329, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001174 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001970 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0004913 ], _:genid113839 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png"^^xsd:anyURI . obo:UBERON_0001066 obo:IAO_0000115 "A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." ; obo:UBPROP_0000008 "strictly speaking the term intervertebral disk [applies to intervertebral cartilage]" ; oboInOwl:hasDbXref "BTO:0003625", "EFO:0001370", "EMAPA:32739", "FMA:10446", "GAID:105", "MA:0000110", "MESH:D007403", "NCIT:C49571", "SCTID:244570000", "UMLS:C0021815", "Wikipedia:Intervertebral_disk" ; oboInOwl:hasExactSynonym "discus intervertebralis", "intervertebral disc", "spinal disc" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intervertebral fibrocartilage", "spinal disk" ; oboInOwl:id "UBERON:0001066" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "whose gel-like core is nucleus puloposus, by this definition only in mammals" ; rdfs:label "intervertebral disk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002242 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray301.png"^^xsd:anyURI . obo:UBERON_0001067 obo:IAO_0000115 "A synovial joint between the prezygapophysis of one vertebra and the postzygapophysis of the vertebra directly above it. There are two facet joints in each spinal motion segment[WP]." ; oboInOwl:hasDbXref "FMA:10447", "GAID:275", "MA:0001513", "MESH:D021801", "NCIT:C32577", "SCTID:89836005", "UMLS:C0224521", "Wikipedia:Zygapophysial_joint" ; oboInOwl:hasExactSynonym "facet joint", "joint of vertebral arch", "joint of vertebral articular process", "spinal facet joint", "zygapophyseal joint", "zygapophysial joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulationes zygapophysiales" ; oboInOwl:id "UBERON:0001067" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "vertebral arch joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003861 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001080 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png"^^xsd:anyURI . obo:UBERON_0001068 obo:IAO_0000115 "A zone of skin that is part of a back [Automatically generated definition]." ; obo:IAO_0000116 "TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ; oboInOwl:hasDbXref "EMAPA:36392", "FMA:10462", "FMA:22985", "MA:0000498", "SCTID:181492002" ; oboInOwl:hasExactSynonym "back skin", "back zone of skin", "skin, dorsal region", "zone of skin of back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001068" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of back" ; rdfs:subClassOf obo:UBERON_0001085, _:genid113879 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0001070 obo:IAO_0000115 "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." ; obo:UBPROP_0000008 "not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO" ; oboInOwl:hasDbXref "AAO:0010218", "AAO:0010416", "BTO:0004696", "EFO:0001953", "EHDAA2:0000461", "EMAPA:18611", "FMA:10635", "GAID:480", "MA:0001929", "MESH:D002342", "NCIT:C32551", "SCTID:362044002", "UMLS:C0007275", "VHOG:0000265", "Wikipedia:External_carotid_artery", "XAO:0000345" ; oboInOwl:hasExactSynonym "external carotid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria carotis externa" ; oboInOwl:id "UBERON:0001070" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "external carotid artery" ; rdfs:seeAlso "https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0005396, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004363 ], _:genid113886, _:genid113888, _:genid113891 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif"^^xsd:anyURI . obo:UBERON_0001071 obo:IAO_0000115 "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." ; oboInOwl:hasDbXref "EMAPA:37117", "FMA:10665", "MA:0002052", "NCIT:C53005", "SCTID:161746006", "UMLS:C0226271", "Wikipedia:Superficial_part_of_transverse_cervical_artery" ; oboInOwl:hasExactSynonym "superficial branch of transverse cervical artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001071" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]" ; rdfs:label "superficial cervical artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0012324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035549 ] ) ] . obo:UBERON_0001072 obo:IAO_0000115 "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." ; obo:UBPROP_0000001 "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." ; obo:UBPROP_0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011083", "BTO:0002682", "EHDAA2:0000611", "EMAPA:18416", "FMA:10951", "GAID:548", "MA:0000480", "MESH:D014682", "NCIT:C12815", "SCTID:181369003", "UMLS:C0042458", "VHOG:0001194", "Wikipedia:Inferior_vena_cava", "XAO:0000388", "galen:InferiorVenaCava" ; oboInOwl:hasExactSynonym "inferior caval vein", "inferior vena cava", "posterior vena cava" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudal vena cava", "postcava", "vena cava inferior" ; oboInOwl:id "UBERON:0001072" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "posterior vena cava" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002078 ] ; owl:disjointWith obo:UBERON_0001585 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004087 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000154 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png"^^xsd:anyURI . obo:UBERON_0001073 obo:IAO_0000115 "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." ; oboInOwl:hasDbXref "EMAPA:37601", "FMA:11338", "MA:0000332", "SCTID:264021000" ; oboInOwl:hasExactSynonym "ileocaecal junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001073" ; a owl:Class ; rdfs:label "ileocecal junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000059 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001074 obo:IAO_0000115 "A potential space between the visceral and parietal layers of the pericardium." ; obo:RO_0002175 obo:NCBITaxon_7718 ; obo:UBPROP_0000001 "Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO]" ; obo:UBPROP_0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" ; obo:UBPROP_0000012 "check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal)" ; oboInOwl:hasDbXref "BSA:0000091", "EHDAA2:0001434", "EMAPA:16131", "EMAPA:16132", "FMA:11350", "MA:0000053", "NCIT:C38662", "SCTID:362027001", "TAO:0002220", "UMLS:C0225972", "VHOG:0000556", "Wikipedia:Pericardial_cavity", "ZFA:0001655", "galen:PericardialSpace" ; oboInOwl:hasExactSynonym "cavity of pericardial sac", "pericardial space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas pericardiaca" ; oboInOwl:id "UBERON:0001074" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pericardial cavity" ; rdfs:subClassOf obo:UBERON_0002323, [ a owl:Restriction ; owl:onProperty obo:RO_0001019 ; owl:someValuesFrom obo:UBERON_0002409 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0002357 ], _:genid113935, _:genid113938 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002406 ] ) ] . obo:UBERON_0001075 obo:IAO_0000115 "Ossified form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." ; obo:UBPROP_0000001 "Centra are represented by mineralized, calcified, or ossified portions that surround the notochord. The autocentrum, present in Danio and all other living teleosts, is formed by direct ossification outside the elastica externa of the notochord (Arratia, 1999).[TAO]", "Cylindrical body of bone, round or oval in cross section, which functionally replaces the notochord.[AAO]", "The body is the largest part of a vertebra, and is more or less cylindrical in shape. Its upper and lower surfaces are flattened and rough, and give attachment to the intervertebral fibrocartilages, and each presents a rim around its circumference. In front, the body is convex from side to side and concave from above downward. Behind, it is flat from above downward and slightly concave from side to side. Its anterior surface presents a few small apertures, for the passage of nutrient vessels. On the posterior surface is a single large, irregular aperture, or occasionally more than one, for the exit of the basi-vertebral veins from the body of the vertebra. [WP,unvetted][Wikipedia:Body_of_vertebra]." ; obo:UBPROP_0000005 "The vertebral centrum may be cartilaginous, develop as cartilage but be replaced by bone or mineralized, or form directly through intramembranous ossification.[VSAO]" ; obo:UBPROP_0000012 "VSAO definition states it surrounds notochord but not applicable to post-natal." ; oboInOwl:hasDbXref "AAO:0000697", "EMAPA:36588", "FMA:11945", "MA:0001457", "NCIT:C12852", "SCTID:361745008", "SCTID:362867001", "TAO:0000126", "UMLS:C0223084", "Wikipedia:Body_of_vertebra", "ZFA:0000126" ; oboInOwl:hasExactSynonym "body of vertebra", "corpus vertebra", "corpus vertebrae (vertebrale)", "vertebral body" ; oboInOwl:hasNarrowSynonym "arcocentrum", "autocentrum", "holocentrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "centra", "corpus vertebrae", "vertebral centra", "vertebral centrum" ; oboInOwl:id "UBERON:0001075" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "bony vertebral centrum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016491 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/63/Corpusvertebrae.png"^^xsd:anyURI . obo:UBERON_0001076 obo:IAO_0000115 "An extension of a neural arches dorsal to the neural canal[TAO,modified]." ; obo:UBPROP_0000001 "Elaboration of the mid-dorsal keel into a posterior or posterolateral process.[AAO]", "Neural spines are extensions of neural arches dorsal to the neural canal in the median skeletogenous septum. Neural spines are typically unpaired median structures but can be paired in some instances, e.g., in the abdominal region of basal teleosts such as Leptolepis, Elops, Megalops, and Hiodon).[TAO]", "Small, posteriorly directed process at the posterior margin of each neural arch lamina; it is not a neural spine.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of mid-dorsal keel (AAO:0000735)[AAO]" ; obo:UBPROP_0000008 "The spinous process of a vertebra is directed backward and downward from the junction of the laminae (in humans), and serves for the attachment of muscles and ligaments. In animals without an erect stance, the process points upward and may slant forward or backward. Spinous processes are exaggerated in some animals, such as the extinct Dimetrodon and Spinosaurus, where they form a sail- or finback. [Wikipedia:Spinous_process]" ; oboInOwl:hasBroadSynonym "spinous process" ; oboInOwl:hasDbXref "AAO:0000705", "EMAPA:25107", "FMA:11948", "MA:0001455", "NCIT:C116112", "SCTID:264259004", "TAO:0001336", "Wikipedia:Spinous_process", "ZFA:0001336" ; oboInOwl:hasExactSynonym "processus spinosus", "processus spinosus vertebrae", "spinous process of vertebra", "vertebra spinous process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural spine", "neural spines", "spine of verterba" ; oboInOwl:id "UBERON:0001076" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neural spine" ; rdfs:subClassOf obo:UBERON_0006061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003861 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Processusspinosusvertebrae.png"^^xsd:anyURI . obo:UBERON_0001077 obo:IAO_0000115 "The transverse or costal processes of a vertebra, two in number, project one at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes. They serve for the attachment of muscles and ligaments. [WP,unvetted]." ; obo:UBPROP_0000001 "Projections on each side of the vertebra from the point where the neural arch lamina joins the pedicel for the articulation with the head of a single-headed rib or the upper head of a double-headed rib. Also called diapophyses. They provide surfaces for the attachment of muscles. In anurans, the term transverse process is used in reference to the processes associated with the presacral and postsacral vertebrae." ; oboInOwl:hasDbXref "AAO:0000698", "FMA:11949", "MA:0001456", "SCTID:264238006", "Wikipedia:Transverse_process", "XAO:0003102" ; oboInOwl:hasExactSynonym "processus transversus", "processus transversus vertebrae", "transverse process", "vertebra transverse process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diapophyses", "diapophysis" ; oboInOwl:id "UBERON:0001077" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "transverse process of vertebra" ; rdfs:subClassOf obo:UBERON_0006061 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Processustransversusvertebrae.PNG"^^xsd:anyURI . obo:UBERON_0001078 obo:IAO_0000115 "The two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae." ; oboInOwl:hasBroadSynonym "pedicle" ; oboInOwl:hasDbXref "FMA:11950", "MA:0001458", "NCIT:C96274", "SCTID:277422007", "UMLS:C0223080", "Wikipedia:Pedicle_of_vertebral_arch" ; oboInOwl:hasExactSynonym "pedicle of vertebral arch", "pediculus arcus vertebrae", "vertebra pedicle", "vertebral pedicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pediculus arcus vertebrae", "radix arcus vertebrae" ; oboInOwl:id "UBERON:0001078" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pedicle of vertebra" ; rdfs:subClassOf obo:UBERON_0006061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003861 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Pediculusarcusvertebrae.png"^^xsd:anyURI . obo:UBERON_0001079 obo:IAO_0000115 "Paired processes at the cephalic end of the neural arch. The articular facets of the prezygapophyses face dorsomedially and articulate with the lateroventrally facing facets of the postzygapophyses of the preceding vertebra." ; obo:IAO_0000116 "TODO - add distinct classes for hemal vs neural?" ; obo:UBPROP_0000001 "Paired, anteromedially directed processes from the neural arches, ligamentously joined to the postzygapophyses of the preceding vertebra.[TAO]" ; oboInOwl:hasDbXref "AAO:0000703", "EMAPA:37802", "FMA:11953", "MA:0001452", "SCTID:42424006", "TAO:0001325", "ZFA:0001325", "http://www.informatics.jax.org/cookbook/figures/figure20.shtml" ; oboInOwl:hasExactSynonym "cranial articular process of vertebra", "prezygapophysis", "processus articularis superior", "processus articularis superior vertebrae", "superior articular process of vertebra", "vertebra cranial articular process", "zygapophysis superior" ; oboInOwl:hasNarrowSynonym "neural prezygapophysis", "neural prezygopophyses" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural prezygapophyses" ; oboInOwl:id "UBERON:0001079" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "prezygapophysis" ; rdfs:subClassOf obo:UBERON_0006062 . obo:UBERON_0001080 obo:IAO_0000115 "Paired processes at the caudal end of the neural arch. The articular facets of the postzygapophyses face lateroventrally and articulate with the dorsomedially facing facets of the prezygapophyses of the succeeding vertebra." ; obo:UBPROP_0000001 "Paired, dorsomedially directed processes on the posterior ends of the centra, ligamentously joined to the neural prezygapophyses of the immediately posterior vertebra.[TAO]" ; oboInOwl:hasDbXref "AAO:0000702", "EMAPA:35918", "FMA:11954", "MA:0001451", "SCTID:30079000", "TAO:0000681", "ZFA:0000681" ; oboInOwl:hasExactSynonym "caudal articular process of vertebra", "inferior articular process of vertebra", "neural postzygopophysis", "postzygapophysis", "processus articularis inferior", "processus articularis inferior vertebrae", "vertebra caudal articular process", "zygapophysis inferior" ; oboInOwl:hasNarrowSynonym "neural postzygapophysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural postzygapophyses", "neural postzygopophyses", "processus obliquus posterior" ; oboInOwl:id "UBERON:0001080" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Posteriorly projecting processes allowing de facto contact between consecutive vertebrae (some soft tissues are also present) via articular facets. [PHENOSCAPE:NI]" ; rdfs:label "postzygapophysis" ; rdfs:subClassOf obo:UBERON_0006062 . obo:UBERON_0001081 obo:IAO_0000115 "Endocardium that is part of the cardiac ventricle." ; oboInOwl:hasDbXref "EMAPA:32747", "FMA:12148", "MA:0000079", "SCTID:192172004", "TAO:0002247", "VHOG:0000607", "ZFA:0001615" ; oboInOwl:hasExactSynonym "cardiac ventricle endocardium", "endocardium of cardiac ventricle", "endocardium of heart ventricle", "endocardium of lower chamber of heart", "endocardium of ventricle of heart", "heart ventricle endocardium", "lower chamber of heart endocardium", "ventricle endocardium", "ventricle of heart endocardium", "ventricular endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventricle endocardial tissue" ; oboInOwl:id "UBERON:0001081" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endocardium of ventricle" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002082 ], _:genid114016 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0001082 obo:IAO_0000115 "An epicardial layer that lines a cardiac ventricle." ; obo:UBPROP_0000001 "The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO]" ; oboInOwl:hasDbXref "FMA:12150", "TAO:0005058", "ZFA:0005058" ; oboInOwl:hasExactSynonym "cardiac ventricle epicardium", "ventricular epicardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001082" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "epicardium of ventricle" ; rdfs:subClassOf obo:UBERON_0002348, _:genid113879 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002348 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0001083 obo:IAO_0000115 "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." ; obo:UBPROP_0000001 "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO]" ; obo:UBPROP_0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EFO:0003088", "EMAPA:32748", "FMA:12151", "MA:0000082", "SCTID:192084000", "TAO:0005061", "VHOG:0000604", "ZFA:0005061" ; oboInOwl:hasExactSynonym "ventricle myocardium", "ventricular myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventricle cardiac muscle" ; oboInOwl:id "UBERON:0001083" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "myocardium of ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ], _:genid113888, _:genid114042 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0001084 obo:IAO_0000115 "A zone of skin that is part of a head [Automatically generated definition]." ; obo:IAO_0000116 "TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ; oboInOwl:hasDbXref "FMA:12166", "FMA:24756", "MA:0000582", "NCIT:C52757", "SCTID:181484006", "UMLS:C0205029" ; oboInOwl:hasExactSynonym "adult head zone of skin", "head skin", "head zone of skin", "zone of skin of adult head", "zone of skin of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001084" ; a owl:Class ; rdfs:label "skin of head" ; rdfs:subClassOf obo:UBERON_0000014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0001085 obo:IAO_0000115 "A zone of skin that is part of a trunk [Automatically generated definition]." ; obo:IAO_0000116 "TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ; oboInOwl:hasDbXref "EMAPA:37278", "FMA:12167", "FMA:23093", "MA:0000517", "NCIT:C12295", "SCTID:181489001", "UMLS:C0205031" ; oboInOwl:hasExactSynonym "torso zone of skin", "trunk skin", "trunk zone of skin", "zone of skin of torso", "zone of skin of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001085" ; a owl:Class ; rdfs:label "skin of trunk" ; rdfs:subClassOf obo:UBERON_0000014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0001087 obo:IAO_0000115 "Transudate contained in the pleural cavity." ; oboInOwl:hasDbXref "BTO:0003080", "FMA:12273", "MA:0002532", "MAT:0000500", "Wikipedia:Pleural_fluid", "ncithesaurus:Pleural_Fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001087" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "pleural fluid" ; rdfs:subClassOf obo:UBERON_0036244 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007779 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002402 ] ) ] . obo:UBERON_0001088 obo:IAO_0000115 "Excretion that is the output of a kidney." ; obo:UBPROP_0000008 "kidney excreta from some taxa (e.g. in aves) may not be liquid" ; oboInOwl:hasDbXref "BTO:0001419", "CALOHA:TS-1092", "EFO:0001939", "EMAPA:36554", "ENVO:00002047", "FMA:12274", "GAID:1189", "MA:0002545", "MAT:0000058", "MESH:D014556", "MIAA:0000058", "NCIT:C13283", "UMLS:C0042036", "Wikipedia:Urine", "galen:Urine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001088" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "urine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000174 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0001089 obo:IAO_0000115 "Secretion produced by a sweat gland." ; oboInOwl:hasDbXref "BTO:0001254", "ENVO:02000025", "FMA:12275", "GAID:1172", "MA:0002539", "MESH:D013542", "NCIT:C13280", "UMLS:C0038984", "Wikipedia:Sweat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin exudate" ; oboInOwl:id "UBERON:0001089" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sweat" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001820 ] ) ] . obo:UBERON_0001090 obo:IAO_0000115 "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." ; obo:UBPROP_0000001 "Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO]" ; obo:UBPROP_0000009 "It provides nutrients and lubrication for articular cartilage" ; obo:UBPROP_0000010 "The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma" ; oboInOwl:hasDbXref "BTO:0001339", "CALOHA:TS-0996", "ENVO:02000039", "FMA:12277", "GAID:265", "MA:0002544", "MESH:D013582", "NCIT:C33718", "TAO:0005154", "UMLS:C0039097", "Wikipedia:Synovial_fluid", "ZFA:0005154", "galen:SynovialFluid" ; oboInOwl:hasExactSynonym "joint fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001090" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "synovial fluid" ; rdfs:subClassOf obo:UBERON_0007794, _:genid113938, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0007617 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid113935 ] . obo:UBERON_0001091 obo:IAO_0000115 "Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food." ; obo:IAO_0000116 "we place ZFA ctb 5 tooth here for now. Consider changing name from calcaeeous tooth. Note that sea cucumbers develop calcareous tooth-like structures" ; obo:RO_0002161 obo:NCBITaxon_189497 ; obo:UBPROP_0000003 "The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes.[well established][VHOG]" ; obo:UBPROP_0000007 "dental" ; obo:UBPROP_0000008 "absent in living platypus, present in toothed Miocene platypus Obduron dicksoni" ; oboInOwl:hasDbXref "AEO:0000220", "BTO:0000397", "CALOHA:TS-1055", "EFO:0000839", "EHDAA2:0004605", "EMAPA:32906", "EV:0100063", "FMA:12516", "GAID:1260", "MA:0000348", "MAT:0000041", "MESH:D014070", "MIAA:0000041", "NCIT:C12506", "SCTID:302214001", "TAO:0001625", "UMLS:C0040426", "VHOG:0001733", "Wikipedia:Tooth", "XAO:0000431", "ZFA:0000694" ; oboInOwl:hasExactSynonym "dental element", "dentine containing tooth", "tooth", "vertebrate tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001091" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "calcareous tooth" ; rdfs:subClassOf obo:UBERON_0003913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001751 ], _:genid114101, _:genid114103, _:genid114105 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg"^^xsd:anyURI . obo:UBERON_0001092 obo:IAO_0000115 "The first vertebral bone in the vertebral column." ; obo:UBPROP_0000001 "First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO]", "Vertebra that is posteriorly adjacent to the neurocranium.[TAO]" ; obo:UBPROP_0000107 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasBroadSynonym "C1" ; oboInOwl:hasDbXref "AAO:0000709", "EHDAA:10606", "EMAPA:19431", "FMA:12519", "GAID:236", "MA:0001421", "MESH:D001270", "NCIT:C32239", "SCTID:181818007", "TAO:0001167", "UMLS:C0004170", "Wikipedia:Atlas_(anatomy)", "ZFA:0001167" ; oboInOwl:hasExactSynonym "C1 vertebra", "atlas", "atlas (CI)", "atlas [C I]", "atlas vertebra", "cervical atlas", "cervical vertebra 1", "first cervical vertebra", "vertebra 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001092" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vertebral bone 1" ; rdfs:subClassOf obo:UBERON_0002412, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0001093 ] . obo:UBERON_0001093 obo:IAO_0000115 "The second vertebral bone in the vertebral column." ; obo:UBPROP_0000001 "Vertebra that is posteriorly adjacent to vertebra 1.[TAO]" ; obo:UBPROP_0000013 "not the same as ZFA term 'axis'" ; obo:UBPROP_0000107 "2"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EHDAA:10608", "EMAPA:19432", "FMA:12520", "GAID:237", "MA:0001422", "MESH:D001368", "NCIT:C32240", "SCTID:181819004", "TAO:0001168", "UMLS:C0004457", "Wikipedia:Axis_(anatomy)", "ZFA:0001168" ; oboInOwl:hasExactSynonym "axis (CII)", "axis [C II]", "axis vertebra", "cervical axis", "vertebra 2" ; oboInOwl:hasNarrowSynonym "C2 vertebra", "cervical vertebra 2", "second cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "C2", "axis" ; oboInOwl:id "UBERON:0001093" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vertebral bone 2" ; rdfs:subClassOf obo:UBERON_0002412, _:genid114122 . obo:UBERON_0001094 obo:IAO_0000115 "A vertebra bone that is part of the sacral region of the vertebral column." ; obo:IAO_0000116 "todo - AAO placement to be confirmed by AAO curators (the AAO class may also include modified ribs)" ; obo:UBPROP_0000001 "Enlarged vertebra with transverse processes (diapophyses), and ocassionally ribs, that are modified and elaborated for support of the pelvic girdle.[AAO]" ; oboInOwl:hasDbXref "AAO:0000552", "EMAPA:18336", "FMA:12526", "MA:0000313", "NCIT:C12853", "SCTID:361773005", "UMLS:C1261045", "Wikipedia:Sacrum", "XAO:0003078", "galen:SacralVertebra", "neuronames:1706" ; oboInOwl:hasExactSynonym "sacral segment", "segment of sacrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001094" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sacral vertebra" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010745 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015010 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001095 obo:IAO_0000115 "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." ; obo:UBPROP_0000001 "Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO]" ; obo:UBPROP_0000012 "we deliberately merge the MA classes as we believe them equivalent" ; oboInOwl:hasAlternativeId "UBERON:0006070" ; oboInOwl:hasBroadSynonym "caudal vertebra" ; oboInOwl:hasDbXref "EMAPA:18374", "FMA:12527", "MA:0000310", "MA:0001420", "NCIT:C32334", "SCTID:361774004", "TAO:0000326", "UMLS:C0223616", "Wikipedia:Caudal_vertebra", "XAO:0003079", "ZFA:0000326", "galen:CoccygealVertebra" ; oboInOwl:hasExactSynonym "caudal vertebrae", "caudal vertebral bone", "caudal vertebral bone element", "coccygeal segment", "coccygeal vertebra", "fused tail vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coccygea", "tail vertebra" ; oboInOwl:id "UBERON:0001095" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae" ; rdfs:label "caudal vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018142 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001096 obo:IAO_0000115 "An anatomical wall that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35326", "FMA:12611", "MA:0002691" ; oboInOwl:hasExactSynonym "anatomical wall of esophagus", "anatomical wall of gullet", "anatomical wall of oesophagus", "esophageal wall", "esophagus anatomical wall", "esophagus wall", "gullet anatomical wall", "gullet wall", "oesophagus anatomical wall", "oesophagus wall", "wall of gullet", "wall of oesophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001096" ; a owl:Class ; rdfs:label "wall of esophagus" ; rdfs:subClassOf obo:UBERON_0000060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0001098 obo:IAO_0000115 "Incisors are the first kind of tooth in heterodont mammals. They are located in the premaxilla above and mandible below. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0001741", "EHDAA:8011", "EHDAA:8047", "EMAPA:32889", "FMA:12823", "GAID:1263", "MA:0000349", "MESH:D007180", "NCIT:C32769", "SCTID:420856006", "UMLS:C0021156", "Wikipedia:Incisor_tooth" ; oboInOwl:hasExactSynonym "incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001098" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Humans normally have eight (8) incisors; Among other animals, some other primates, cats and horses have twelve. Rodents have four, while Foxes have nine. Rabbits and hares (lagomorphs) were once considered rodents, but are distinguished by having eight - one small pair, called 'peg teeth', is located directly behind the most anterior pair. Incisors are used to bite off tough foods, such as red meat" ; rdfs:label "incisor tooth" ; rdfs:subClassOf obo:UBERON_0001091, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003672 ] ; owl:disjointWith obo:UBERON_0003655, obo:UBERON_0003674, obo:UBERON_0007120 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Gray997.png"^^xsd:anyURI . obo:UBERON_0001100 obo:IAO_0000115 "The Pectoralis minor is a thin, triangular muscle, situated at the upper part of the chest, beneath the Pectoralis major. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0001425", "EHDAA:8313", "EMAPA:18180", "FMA:13109", "MA:0002355", "NCIT:C33285", "SCTID:181625002", "UMLS:C0224347", "VHOG:0000902", "Wikipedia:Pectoralis_minor_muscle" ; oboInOwl:hasExactSynonym "pectoralis minor muscle" ; oboInOwl:hasNarrowSynonym "supracoracoideus", "supracoracoideus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus pectoralis minor" ; oboInOwl:id "UBERON:0001100" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pectoralis minor" ; rdfs:subClassOf obo:UBERON_0001495, _:genid114175, _:genid114177 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png"^^xsd:anyURI . obo:UBERON_0001103 obo:IAO_0000115 "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." ; obo:UBPROP_0000001 "The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs[GO]." ; obo:UBPROP_0000003 "The mammals are characterized by a diaphragm, which separates the thoracic portion of the body cavity from the abdominal region and assists in drawing air into the lungs and forcing it out. Modern reptiles lack a muscular diaphragm and it is reasonable to suppose that the diaphragm developed as a new device that made possible a large degree of oxygen intake for active animals. The change may have taken place during the transition from reptile to mammal (...).[well established][VHOG]" ; obo:UBPROP_0000007 "phrenic" ; obo:UBPROP_0000008 "The existence of some membrane separating the pharynx from the stomach can be traced widely among the chordates. Thus amphioxus possesses an atrium by which water exits the pharynx, which has been argued (and disputed) to be homologous to structures in ascidians and hagfishes.[3]", "The urochordate epicardium separates digestive organs from the pharynx and heart, but the anus returns to the upper compartment to discharge wastes through an outgoing siphon (Thoracic_diaphragm#Comparative_anatomy_and_evolution)" ; obo:UBPROP_0000009 "barrier between thoracic and abdominal cavities; stop gastric contents from refluxing into the oesophagus", "breathing control" ; obo:UBPROP_0000011 "originate from the cervical somites, likely C3-C5[PMID:23586979]" ; oboInOwl:hasDbXref "BTO:0000341", "CALOHA:TS-0198", "EFO:0000937", "EHDAA2:0003495", "EMAPA:17701", "EV:0100376", "FMA:13295", "GAID:158", "MA:0001904", "MAT:0000502", "MESH:D003964", "NCIT:C12702", "SCTID:181614006", "UMLS:C0011980", "VHOG:0000713", "Wikipedia:Thoracid_diaphragm" ; oboInOwl:hasExactSynonym "diaphragm muscle", "diaphragm of thorax", "thoracic diaphragm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "midriff", "phren" ; oboInOwl:id "UBERON:0001103" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "diaphragm" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001884 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001134 ], _:genid114188 . obo:UBERON_0001105 obo:IAO_0000115 "A paired dermal or endochondral bone that is part of the pectoral girdle. The clavicle may be in contact with the interclavicle or coracoid and forms an attachment site for pectoral musculature. [PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "Slender, paired bones of intramembranous origin that invest the anterior margins of the procoracoids.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of zonal element (AAO:0000936)[AAO]" ; obo:UBPROP_0000003 "In early tetrapods, the connecting skull bone, the posttemporal, and adjoining shoulder bones, supracleithrum and postcleithrum (=anocleithrum), are absent, leaving a dermal shoulder girdle composed of the remaining ventral elements: the paired cleithrum and clavicle, and an unpaired midventral interclavicle that joins both halves of the girdle across the midline. (...) Several dermal elements of the shoulder persist in early synapsids. The clavicle and interclavicle are present in therapsids and monotremes, but in marsupials and placentals, the interclavicle is absent, the clavicle often is reduced in size, and the scapula becomes the predominant shoulder element.[well established][VHOG]" ; obo:UBPROP_0000007 "clavicular" ; obo:UBPROP_0000008 "The clavicle first appears as part of the skeleton in primitive bony fish, where it is associated with the pectoral fin; they also have a bone called the cleithrum. In such fish, the paired clavicles run behind and below the gills on each side, and are joined by a solid symphysis on the fish's underside. They are, however, absent in cartilagenous fish and in the vast majority of living bony fish, including all of the teleosts[ISBN 0-03-910284-X]." ; obo:UBPROP_0000011 "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." ; obo:UBPROP_0000012 "FMA and MA differ in whether they consider this part of the shoulder" ; oboInOwl:hasDbXref "AAO:0000761", "EMAPA:18721", "FMA:13321", "GAID:182", "MA:0001329", "MESH:D002968", "MFMO:0000047", "NCIT:C12695", "SCTID:181910004", "UMLS:C0008913", "VHOG:0000849", "VSAO:0005031", "Wikipedia:Clavicle", "galen:Clavicle" ; oboInOwl:hasExactSynonym "clavicle", "clavicula", "collar bone", "collarbone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001105" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "clavicle bone" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002091 ], _:genid114198, _:genid114201, _:genid114203 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg"^^xsd:anyURI . obo:UBERON_0001111 obo:IAO_0000115 "The respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib." ; obo:UBPROP_0000003 "Inspiration by active expansion of the thorax evolved later, in the ancestor of reptiles, birds, and mammals. This was powered originally by the intercostal muscles (as in lizards or crocodilians) and later (in mammals only) by a muscular diaphragm.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0005281", "EFO:0001368", "EHDAA2:0000841", "EHDAA:5988", "EMAPA:18521", "FMA:13354", "GAID:159", "MA:0002324", "MA:0003165", "MESH:D007366", "NCIT:C32824", "SCTID:181746004", "UMLS:C0021724", "VHOG:0000903", "Wikipedia:Intercostal_muscle" ; oboInOwl:hasExactSynonym "musculus intercostalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intercostales", "respiratory muscle", "rib muscle" ; oboInOwl:id "UBERON:0001111" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "intercostal muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ], _:genid114223, _:genid114225, _:genid114227, _:genid114229 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0012198 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002228 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002228 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray411.png"^^xsd:anyURI . obo:UBERON_0001112 obo:IAO_0000115 "The latissimus dorsi is the larger, flat, dorso-lateral muscle on the trunk, posterior to the arm, and partly covered by the trapezius on its median dorsal region. [WP,unvetted]." ; obo:UBPROP_0000008 "In humans it inserts along a roughened line deep in the groove. In other mammals (most, I believe) it is an actual projection, the latissimus dorsi process [FEED:rd] [https://github.com/obophenotype/uberon/issues/1192]" ; oboInOwl:hasDbXref "EFO:0003067", "EHDAA2:0000932", "EHDAA:8307", "EMAPA:18178", "FMA:13357", "MA:0002331", "NCIT:C33150", "SCTID:181747008", "UMLS:C0224362", "VHOG:0000930", "Wikipedia:Latissimus_dorsi_muscle" ; oboInOwl:hasExactSynonym "dorsal latissimus muscle", "latissimi dorsi", "latissimus dorsi", "musculus latissimus dorsi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus latissimus dorsi" ; oboInOwl:id "UBERON:0001112" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Dorsal group[Kardong]" ; rdfs:label "latissimus dorsi muscle" ; rdfs:subClassOf obo:UBERON_0001482, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006849 ], _:genid114235, _:genid114237, _:genid114240, _:genid114242, _:genid114244, _:genid114246 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png"^^xsd:anyURI . obo:UBERON_0001113 obo:IAO_0000115 "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." ; obo:IAO_0000116 "some work needs to be done to ensure the child terms of this class have correct isa/partof placement. in MA they are subclasses, in FMA they are parts" ; oboInOwl:hasDbXref "EMAPA:18306", "FMA:13361", "MA:0000360", "NCIT:C49579", "SCTID:245378000", "UMLS:C0447541", "Wikipedia:Liver#Lobes" ; oboInOwl:hasExactSynonym "hepatic lobe", "liver lobe", "lobus hepatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001113" ; a owl:Class ; rdfs:label "lobe of liver" ; rdfs:subClassOf obo:UBERON_0009912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] . obo:UBERON_0001114 obo:IAO_0000115 "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." ; obo:UBPROP_0000001 "Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO]" ; oboInOwl:hasDbXref "EHDAA2:0001008", "EHDAA:4001", "EMAPA:18311", "FMA:13362", "MA:0000363", "NCIT:C33481", "SCTID:362182008", "TAO:0005173", "UMLS:C0227481", "VHOG:0001424", "Wikipedia:Right_lobe_of_liver", "ZFA:0005173" ; oboInOwl:hasExactSynonym "liver right lobe", "lobus hepaticus dexter", "right liver lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd lobe", "gall bladder lobe", "lobus hepatis dexter", "right hepatic lobe", "second lobe" ; oboInOwl:id "UBERON:0001114" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "right lobe of liver" ; rdfs:subClassOf obo:UBERON_0001113 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png"^^xsd:anyURI . obo:UBERON_0001115 obo:IAO_0000115 "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." ; obo:UBPROP_0000001 "Portion of the liver which develops on the fish's left side.[TAO]" ; oboInOwl:hasDbXref "EHDAA2:0001000", "EHDAA:3995", "EMAPA:18307", "FMA:13363", "MA:0000361", "NCIT:C32965", "SCTID:362183003", "TAO:0005172", "UMLS:C0227486", "VHOG:0001423", "Wikipedia:Left_lobe_of_liver", "ZFA:0005172" ; oboInOwl:hasExactSynonym "left liver lobe", "liver left lobe", "lobus hepaticus sinister" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "left hepatic lobe", "lobus hepatis sinister" ; oboInOwl:id "UBERON:0001115" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "left lobe of liver" ; rdfs:subClassOf obo:UBERON_0001113 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png"^^xsd:anyURI . obo:UBERON_0001118 obo:IAO_0000115 "A lobe of tissue that is part of a thyroid gland." ; obo:UBPROP_0000003 "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0002032", "EMAPA:18196", "FMA:13367", "MA:0000131", "NCIT:C33784", "SCTID:245537001", "UMLS:C0447647", "VHOG:0000732", "Wikipedia:Lobes_of_thyroid_gland" ; oboInOwl:hasExactSynonym "lobus (glandula thyroidea)", "lobus glandulae thyroideae", "thyroid gland lobe", "thyroid lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobuli glandulae thyroideae" ; oboInOwl:id "UBERON:0001118" ; a owl:Class ; rdfs:comment "The lobes of the thyroid gland are conical in shape, the apex of each being directed upward and lateralward as far as the junction of the middle with the lower third of the thyroid cartilage; the base looks downward, and is on a level with the fifth or sixth tracheal ring. Each lobe is about 5 cm. long; its greatest width is about 3 cm. , and its thickness about 2 cm. The lateral or superficial surface is convex, and covered by the skin, the superficial and deep fasciæ, the Sternocleidomastoideus, the superior belly of the Omohyoideus, the Sternohyoideus and Sternothyreoideus, and beneath the last muscle by the pretracheal layer of the deep fascia, which forms a capsule for the gland. The deep or medial surface is moulded over the underlying structures, viz. , the thyroid and cricoid cartilages, the trachea, the Constrictor pharyngis inferior and posterior part of the Cricothyreoideus, the esophagus (particularly on the left side of the neck), the superior and inferior thyroid arteries, and the recurrent nerves. The anterior border is thin, and inclines obliquely from above downward toward the middle line of the neck, while the posterior border is thick and overlaps the common carotid artery, and, as a rule, the parathyroids" ; rdfs:label "lobe of thyroid gland" ; rdfs:subClassOf _:genid114276 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png"^^xsd:anyURI . obo:UBERON_0001119 obo:IAO_0000115 "A lobe of thyroid gland that is in the right side of a thyroid gland." ; obo:UBPROP_0000003 "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0001759", "EMAPA:18198", "FMA:13368", "MA:0000729", "NCIT:C33491", "SCTID:170482008", "UMLS:C0229581", "VHOG:0000733" ; oboInOwl:hasExactSynonym "lobus dexter (glandula thyroidea)", "right thyroid lobe", "thyroid gland right lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001119" ; a owl:Class ; rdfs:label "right lobe of thyroid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001118 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0001120 obo:IAO_0000115 "A lobe of thyroid gland that is in the left side of a thyroid gland." ; obo:UBPROP_0000003 "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0000965", "EMAPA:18197", "FMA:13369", "MA:0000728", "NCIT:C32973", "SCTID:170784008", "UMLS:C0229582", "VHOG:0000734" ; oboInOwl:hasExactSynonym "left thyroid lobe", "lobus sinister (glandula thyroidea)", "thyroid gland left lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001120" ; a owl:Class ; rdfs:label "left lobe of thyroid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001118 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0001125 obo:IAO_0000115 "The serratus ventralis is a muscle that originates on the surface of the upper eight or nine ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0001832", "EHDAA:9463", "EMAPA:18525", "FMA:13397", "MA:0002378", "NCIT:C53014", "SCTID:181748003", "UMLS:C1710059", "VHOG:0000679", "Wikipedia:Serratus_anterior_muscle" ; oboInOwl:hasExactSynonym "Boxer's muscle", "serratus anterior", "serratus anterior muscle", "serratus ventralis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus serratus anterior", "serratus lateralis" ; oboInOwl:id "UBERON:0001125" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "serratus ventralis" ; rdfs:subClassOf obo:UBERON_0001482, _:genid114297, _:genid114299, _:genid114301, _:genid114303, _:genid114305 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png"^^xsd:anyURI . obo:UBERON_0001130 obo:IAO_0000115 "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." ; obo:IAO_0000116 "Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton" ; obo:UBPROP_0000001 "Anatomical cluster that consists of all the vertebra in the body.[VSAO]", "The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "spine" ; oboInOwl:hasDbXref "AAO:0000699", "AAO:0000734", "BTO:0000818", "EFO:0001369", "EHDA:10119", "EMAPA:35919", "FMA:13478", "GAID:106", "MA:0002416", "MESH:D013131", "NCIT:C12998", "NCIT:C33588", "NIF_Subcellular:sao1145756102", "SCTID:44300000", "TAO:0001559", "UMLS:C0037949", "UMLS:C1519455", "VHOG:0001142", "VSAO:0000185", "Wikipedia:Vertebral_column", "XAO:0003074", "ZFA:0001559", "galen:SpinalColumn" ; oboInOwl:hasNarrowSynonym "backbone", "vertebral column skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columna vertebralis", "dorsal spine", "spinal column", "vertebral region" ; oboInOwl:id "UBERON:0001130" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vertebral column" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0002240 ], _:genid114316 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000075 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0010913 ] ) ] . obo:UBERON_0001131 obo:IAO_0000115 "A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch." ; obo:UBPROP_0000001 "Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO]" ; oboInOwl:hasDbXref "AAO:0000729", "EMAPA:37803", "FMA:13479", "MA:0001454", "SCTID:280734009", "Wikipedia:Vertebral_foramen" ; oboInOwl:hasExactSynonym "vertebra neural canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramen vertebrale" ; oboInOwl:id "UBERON:0001131" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "vertebral foramen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006692 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0002240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002571 ; owl:someValuesFrom obo:UBERON_0010913 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png"^^xsd:anyURI . obo:UBERON_0001132 obo:IAO_0000115 "The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism." ; obo:UBPROP_0000001 "Any one of several small structures, usually four, attached to the dorsal surfaces of the lateral lobes of the thyroid gland. [TFD][VHOG]", "Either of the two pairs of small, spherical, encapsulated glands which develop from ventral growths of the third and fourth pharyngeal pouches and are closely associated with the external jugular veins. Calcitonin and parathyroid hormone are secreted by these glands.[AAO]" ; obo:UBPROP_0000003 "The evolution of the tetrapods, and the shift from an aquatic to a terrestrial environment, was believed to have required new controls for regulating calcium homeostasis, and thus the evolution of parathyroid glands (...) both the tetrapod parathyroid and the gills of fish contribute to the regulation of extracellular calcium levels. It is therefore reasonable to suggest that the parathyroid gland evolved as a result of the transformation of the gills into the parathyroid glands of tetrapods and the transition from an aquatic to a terrestrial environment. This interpretation would also explain the positioning of the parathyroid gland within the pharynx in the tetrapod body. Were the parathyroid gland to have emerged de novo with the evolution of the tetrapods it could, as an endocrine organ, have been placed anywhere in the body and still exert its effect.[well established][VHOG]" ; obo:UBPROP_0000008 "Parathyroid glands are found in all adult tetrapods, although they vary in their number, and in their exact position. Mammals typically have four parathyroids, while other groups typically have six. Fish do not possess parathyroid glands, although the ultimobranchial glands, which are found close to the oesophagus, may have a similar function and could even be homologous with the tetrapod parathyroids. Even these glands are absent in the most primitive vertebrates, the jawless fish, but as these species have no bone in their skeletons, only cartilage, it may be that they have less need to regulate calcium metabolism. The conserved homology of genes and calcium-sensing receptors in fish gills with those in the parathryroid glands of birds and mammals is recognized by evolutionary developmental biology as evolution-using genes and gene networks in novel ways to generate new structures with some similar functions and novel functions[WP]" ; obo:UBPROP_0000011 "In humans and chick it emerges from pouches 3 and 4, but in mice it is exclusively generated by the third pouch", "table 13.1 of Kardong is used to create the taxon-specific developmental relationships here, although some omissions are made for simplicity." ; oboInOwl:hasDbXref "AAO:0010545", "BTO:0000997", "CALOHA:TS-0745", "EFO:0000862", "EMAPA:32812", "EV:0100134", "FMA:13890", "GAID:452", "MA:0000128", "MAT:0000082", "MESH:D010280", "MIAA:0000082", "NCIT:C12765", "SCTID:181121007", "UMLS:C0030518", "VHOG:0001188", "Wikipedia:Parathyroid_gland", "XAO:0000167" ; oboInOwl:hasExactSynonym "parathyroid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelial body", "parathyroid secreting cell" ; oboInOwl:id "UBERON:0001132" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "parathyroid gland" ; rdfs:subClassOf obo:UBERON_0002530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035898 ], _:genid114345 . obo:UBERON_0001133 obo:IAO_0000115 "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." ; obo:IAO_0000116 "check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit" ; oboInOwl:hasAlternativeId "UBERON:0007096" ; oboInOwl:hasDbXref "AAO:0010245", "AEO:0000142", "BILA:0000134", "BTO:0000199", "CALOHA:TS-0440", "EHDAA2:0003142", "EMAPA:32688", "FMA:14068", "TAO:0005280", "Wikipedia:Cardiac_muscle", "ZFA:0005280", "galen:CardiacMuscle", "galen:CardiacMuscleTissue", "ncithesaurus:Heart_Muscle" ; oboInOwl:hasExactSynonym "cardiac muscle", "cardiac muscle muscle tissue", "cardiac muscle textus muscularis", "heart muscle muscle tissue", "heart muscle textus muscularis", "heart myocardium muscle tissue", "heart myocardium textus muscularis", "muscle of heart muscle tissue", "muscle of heart textus muscularis", "muscle tissue of cardiac muscle", "muscle tissue of heart muscle", "muscle tissue of heart myocardium", "muscle tissue of muscle of heart", "muscle tissue of myocardium", "myocardium muscle tissue", "myocardium textus muscularis", "textus muscularis of cardiac muscle", "textus muscularis of heart muscle", "textus muscularis of heart myocardium", "textus muscularis of muscle of heart", "textus muscularis of myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac musculature" ; oboInOwl:id "UBERON:0001133" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cardiac muscle tissue" ; rdfs:subClassOf obo:UBERON_8600006, _:genid114175, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000746 ] ; owl:disjointWith obo:UBERON_0001134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000746 ] ) ] . obo:UBERON_0001134 obo:IAO_0000115 "Muscle tissue that consists primarily of skeletal muscle fibers." ; obo:IAO_0000116 "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." ; obo:UBPROP_0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]", "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" ; obo:UBPROP_0000003 "This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "skeletal muscle" ; oboInOwl:hasDbXref "EMAPA:32716", "FMA:14069", "MA:0002439", "NCIT:C13050", "SCTID:426215008", "UMLS:C0242692", "Wikipedia:Skeletal_striated_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle system", "somatic muscle" ; oboInOwl:id "UBERON:0001134" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "skeletal muscle tissue" ; rdfs:subClassOf _:genid114203, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 _:genid114201 ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg"^^xsd:anyURI . obo:UBERON_0001135 obo:IAO_0000115 "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." ; obo:UBPROP_0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]", "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" ; obo:UBPROP_0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" ; obo:UBPROP_0000013 "GO uses visceral and smooth interchangeably. However visceral can also be used in the sense of the viscera. Many fly annotations to smooth muscle terms. If we want to be inclusive of insects have to have a general definition of tissue that includes cells." ; oboInOwl:hasDbXref "AAO:0010244", "AEO:0000141", "BTO:0001260", "CALOHA:TS-0943", "EFO:0000889", "EHDAA2:0003141", "EMAPA:32717", "EV:0100378", "FMA:14070", "GAID:167", "MA:0000166", "MAT:0000303", "MESH:D009130", "MIAA:0000303", "NCIT:C12437", "TAO:0005274", "UMLS:C1267092", "VHOG:0001246", "WBbt:0005781", "Wikipedia:Smooth_muscle_tissue", "XAO:0000175", "ZFA:0005274", "galen:SmoothMuscle", "galen:SmoothMuscleTissue" ; oboInOwl:hasExactSynonym "involuntary muscle", "non-striated muscle", "smooth muscle", "textus muscularis nonstriatus" ; oboInOwl:hasNarrowSynonym "visceral muscle", "visceral muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "textus muscularis levis; textus muscularis nonstriatus" ; oboInOwl:id "UBERON:0001135" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "smooth muscle tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000192 ] ; owl:disjointWith obo:UBERON_0002036 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000192 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg"^^xsd:anyURI . obo:UBERON_0001136 obo:IAO_0000115 "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." ; oboInOwl:hasDbXref "AEO:0000111", "BTO:0002422", "CALOHA:TS-1183", "EHDAA2_RETIRED:0003111", "EHDAA:2331", "EHDAA:2349", "EHDAA:295", "EHDAA:6073", "EHDAA:640", "EHDAA:646", "EMAPA:32856", "FMA:14074", "MA:0000565", "NCIT:C33105", "SCTID:361918002", "UMLS:C0086610", "Wikipedia:Mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001136" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "mesothelium" ; rdfs:subClassOf _:genid114416 ; owl:equivalentClass _:genid114227 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg"^^xsd:anyURI . obo:UBERON_0001137 obo:IAO_0000115 "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." ; obo:UBPROP_0000007 "dorsal" ; obo:UBPROP_0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" ; oboInOwl:hasDbXref "BTO:0001713", "CALOHA:TS-2223", "EFO:0001405", "FMA:14181", "GAID:30", "MESH:D001415", "NCIT:C13062", "SCTID:123961009", "UMLS:C0004600", "Wikipedia:Dorsum_(anatomy)", "galen:Back" ; oboInOwl:hasExactSynonym "back", "back of body proper", "dorsal part of organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001137" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "dorsum" ; rdfs:subClassOf obo:UBERON_0000475 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG"^^xsd:anyURI . obo:UBERON_0001138 obo:IAO_0000115 "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0002783", "EHDAA2:0001951", "EHDAA:5414", "EMAPA:18643", "FMA:14332", "MA:0002179", "NCIT:C33687", "SCTID:278031001", "UMLS:C0226742", "VHOG:0000552", "Wikipedia:Superior_mesenteric_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper mesenteric vein", "vena mesenterica superior" ; oboInOwl:id "UBERON:0001138" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "superior mesenteric vein" ; rdfs:subClassOf _:genid114244, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001639 ], _:genid114430 ; owl:equivalentClass _:genid114240 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png"^^xsd:anyURI . obo:UBERON_0001139 obo:IAO_0000115 "A vein that drains the pelvis and lower limbs into the inferior vena cava." ; obo:UBPROP_0000008 "In human anatomy, the common iliac veins are formed by the external iliac veins and internal iliac veins and together, in the abdomen at the level of the fifth lumbar vertebrae, form the inferior vena cava. They drain blood from the pelvis and lower limbs. Both common iliac veins are accompanied along their course by common iliac arteries." ; oboInOwl:hasDbXref "EMAPA:17874", "FMA:14333", "MA:0002143", "NCIT:C32359", "SCTID:181398004", "UMLS:C0226758", "Wikipedia:Common_iliac_vein", "galen:CommonIliacVein" ; oboInOwl:hasExactSynonym "common iliac venous tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena iliaca communis" ; oboInOwl:id "UBERON:0001139" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "common iliac vein" ; rdfs:subClassOf obo:UBERON_0005610, [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0010708 ], _:genid114437 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif"^^xsd:anyURI . obo:UBERON_0001140 obo:IAO_0000115 "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." ; obo:UBPROP_0000001 "The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]." ; obo:UBPROP_0000012 "in EHDAA2, the renal vein is part of the kidney" ; oboInOwl:hasDbXref "BTO:0002681", "EHDAA2:0001602", "EHDAA:8722", "EMAPA:28376", "FMA:14334", "GAID:544", "MA:0002210", "MESH:D012082", "NCIT:C33462", "SCTID:116358006", "UMLS:C0035092", "Wikipedia:Renal_vein", "galen:RenalVein" ; oboInOwl:hasExactSynonym "kidney vein", "renal venous tree", "vein of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae renales" ; oboInOwl:id "UBERON:0001140" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "renal vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png"^^xsd:anyURI . obo:UBERON_0001141 obo:IAO_0000115 "A renal vein that drains the right kidney." ; obo:UBPROP_0000001 "A vein that drains blood from the right kidney into the inferior vena cava[ncithesaurus]." ; oboInOwl:hasDbXref "EMAPA:37381", "FMA:14335", "MA:0002212", "NCIT:C52695", "SCTID:116357001", "UMLS:C0508000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001141" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "right renal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001140 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0004539 ] ) ] . obo:UBERON_0001142 obo:IAO_0000115 "A renal vein that drains the left kidney." ; obo:UBPROP_0000001 "A vein that drains blood from the left kidney into the inferior vena cava[ncithesaurus]." ; oboInOwl:hasDbXref "EMAPA:37166", "FMA:14336", "MA:0002211", "NCIT:C52693", "SCTID:116356005", "UMLS:C0508001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001142" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "left renal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001140 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0004538 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png"^^xsd:anyURI . obo:UBERON_0001143 obo:IAO_0000115 "Vein that carries blood away from the liver[ZFA]." ; obo:IAO_0000116 "todo - add developmental relationships for other taxa" ; oboInOwl:hasDbXref "AAO:0010216", "EMAPA:19221", "FMA:14337", "GAID:534", "MA:0003015", "MESH:D006503", "NCIT:C32736", "SCTID:278191001", "TAO:0000670", "UMLS:C0019155", "Wikipedia:Hepatic_vein", "XAO:0000387", "ZFA:0000670", "galen:HepaticVein" ; oboInOwl:hasExactSynonym "liver vein", "vein of liver", "vena hepatica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic veins", "venae hepaticae" ; oboInOwl:id "UBERON:0001143" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatic vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006877 ], _:genid114477 ; owl:disjointWith obo:UBERON_0001639 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png"^^xsd:anyURI . obo:UBERON_0001144 obo:IAO_0000115 "A vein that carries deoxygenated blood from a single male gonad. It is the male equivalent of the ovarian vein, and is the venous counterpart of the testicular artery. It is a paired vein, with one supplying each testis." ; obo:IAO_0000116 "TODO - check testicular vs spermatic vein (MA:0002218)" ; obo:UBPROP_0000008 "In humans, the right testicular vein generally joins the inferior vena cava; the left testicular vein, unlike the right, often joins the left renal vein instead of the inferior vena cava. The veins emerge from the back of the testis, and receive tributaries from the epididymis; they unite and form a convoluted plexus, called the pampiniform plexus, which constitutes the greater mass of the spermatic cord; the vessels composing this plexus are very numerous, and ascend along the cord, in front of the ductus deferens. Below the subcutaneous inguinal ring, they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins, which ascend on the Psoas major, behind the peritoneum, lying one on either side of the internal spermatic artery. These unite to form a single vein, which opens, on the right side, into the inferior vena cava (at an acute angle), on the left side into the left renal vein (at a right angle). The spermatic veins are provided with valves. The left spermatic vein passes behind the iliac colon and is thus exposed to pressure from the contents of that part of the bowel" ; oboInOwl:hasDbXref "BTO:0002678", "EMAPA:18647", "FMA:14344", "MA:0002218", "MA:0002234", "NCIT:C53050", "SCTID:264496006", "UMLS:C0226718", "Wikipedia:Testicular_vein" ; oboInOwl:hasExactSynonym "male gonadal vein", "spermatic vein", "testicle vein", "testicular venous tree", "vein of testicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena tesicularis", "vena testicularis dextra", "vena testicularis sinistra", "venae spermaticae" ; oboInOwl:id "UBERON:0001144" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "testicular vein" ; rdfs:subClassOf obo:UBERON_0001638, _:genid114303, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001072 ], _:genid114305, [ a owl:Restriction ; owl:onProperty core:sexually_homologous_to ; owl:someValuesFrom obo:UBERON_0001145 ] ; owl:equivalentClass _:genid114299 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray590.png"^^xsd:anyURI . obo:UBERON_0001145 obo:IAO_0000115 "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." ; oboInOwl:hasDbXref "EMAPA:18644", "FMA:14346", "MA:0002186", "NCIT:C53058", "SCTID:278193003", "UMLS:C0226720", "Wikipedia:Ovarian_vein" ; oboInOwl:hasExactSynonym "female reproductive system gonad vein", "female reproductive system gonada vein", "gonad of female reproductive system vein", "gonada of female reproductive system vein", "ovary vein", "vein of female reproductive system gonad", "vein of female reproductive system gonada", "vein of gonad of female reproductive system", "vein of gonada of female reproductive system", "vein of ovary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena ovarica dextra", "vena ovarica sinistra" ; oboInOwl:id "UBERON:0001145" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "ovarian vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg"^^xsd:anyURI . obo:UBERON_0001146 obo:IAO_0000115 "A vein that drains the adrenal gland." ; oboInOwl:hasDbXref "EHDAA2:0001966", "EHDAA:8731", "FMA:14348", "MA:0002081", "MA:0002229", "NCIT:C53129", "SCTID:278194009", "UMLS:C0226717", "Wikipedia:Suprarenal_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal vein" ; oboInOwl:id "UBERON:0001146" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "suprarenal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png"^^xsd:anyURI . obo:UBERON_0001148 obo:IAO_0000115 "A nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery. It originates from the brachial plexus with roots from C5, C6, C7, C8 & T1." ; oboInOwl:hasDbXref "EHDAA2:0001086", "EHDAA:5648", "EMAPA:17277", "FMA:14385", "GAID:843", "MA:0001168", "MESH:D008475", "NCIT:C52815", "SCTID:181010001", "UMLS:C0025058", "Wikipedia:Median_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus medianus" ; oboInOwl:id "UBERON:0001148" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "The median nerve is the only nerve that passes through the carpal tunnel, where it may be compressed to cause carpal tunnel syndrome. [WP]" ; rdfs:label "median nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ], _:genid114345 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Nerves_of_the_left_upper_extremity.gif"^^xsd:anyURI . obo:UBERON_0001152 obo:IAO_0000115 "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." ; obo:UBPROP_0000001 "Duct that connects the gall bladder and the common bile duct.[TAO]", "The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000333", "EHDAA:3045", "EMAPA:16841", "FMA:14539", "GAID:290", "MA:0000355", "MESH:D003549", "NCIT:C32421", "SCTID:245398005", "TAO:0005166", "UMLS:C0010672", "VHOG:0000213", "Wikipedia:Cystic_duct", "ZFA:0005166", "galen:CysticDuct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus cysticus" ; oboInOwl:id "UBERON:0001152" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cystic duct" ; rdfs:subClassOf obo:UBERON_0003703, [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001970 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001174 ], _:genid114543, _:genid114545 ; owl:disjointWith obo:UBERON_0005171 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001174 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png"^^xsd:anyURI . obo:UBERON_0001155 obo:IAO_0000115 "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." ; obo:IAO_0000116 "Some references do not consider the caecum to be part of the colon.", "TODO - abstract this such that it legitimately covers all vertebrates" ; obo:UBPROP_0000001 "The last portion of the digestive system, it extracts water and salt from solid wastes before they are eliminated from the body.[AAO]", "The posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates. Wallace et al, 2005.[TAO]" ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; obo:UBPROP_0000007 "colonic" ; obo:UBPROP_0000008 "In mammals, the colon consists of four sections: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon[WP]", "In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN]" ; obo:UBPROP_0000009 "it extracts water and salt from solid wastes before they are eliminated from the body[WP]" ; oboInOwl:hasDbXref "AAO:0010400", "BTO:0000269", "CALOHA:TS-0158", "EFO:0000361", "EMAPA:18939", "EV:0100079", "FMA:14543", "GAID:309", "MA:0000335", "MAP:0000001", "MAT:0000526", "MESH:D003106", "NCIT:C12382", "SCTID:302508007", "TAO:0000706", "UMLS:C0009368", "VHOG:0000648", "Wikipedia:Colon_(anatomy)", "XAO:0000243", "ZFA:0000706", "galen:Colon" ; oboInOwl:hasExactSynonym "large bowel" ; oboInOwl:hasNarrowSynonym "posterior intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindgut" ; oboInOwl:id "UBERON:0001155" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "colon" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000059 ], _:genid114555 . obo:UBERON_0001158 obo:IAO_0000115 "The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon." ; oboInOwl:hasDbXref "BTO:0000641", "CALOHA:TS-2010", "EFO:0000845", "EMAPA:35285", "FMA:14547", "MA:0001542", "MAT:0000313", "MESH:D044683", "MIAA:0000313", "NCIT:C12268", "SCTID:362165006", "UMLS:C0227389", "Wikipedia:Descending_colon", "galen:DescendingColon" ; oboInOwl:hasExactSynonym "colon descendens" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001158" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "descending colon" ; rdfs:subClassOf obo:UBERON_0000168, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001159 ], _:genid114566 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray1223.png"^^xsd:anyURI . obo:UBERON_0001159 obo:IAO_0000115 "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." ; oboInOwl:hasDbXref "BTO:0000645", "CALOHA:TS-2044", "EFO:0000846", "EMAPA:36391", "FMA:14548", "MAT:0000314", "MESH:D012809", "MIAA:0000314", "NCIT:C12384", "NCIT:C33550", "SCTID:362166007", "UMLS:C0227391", "UMLS:C0682612", "Wikipedia:Sigmoid_colon", "galen:SigmoidColon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "colon sigmoideum", "pelvic colon", "sigmoid colon", "sigmoid flexure" ; oboInOwl:id "UBERON:0001159" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "sigmoid colon" ; rdfs:subClassOf obo:UBERON_0000168, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001052 ], _:genid114573 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg"^^xsd:anyURI . obo:UBERON_0001161 obo:IAO_0000115 "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." ; obo:IAO_0000116 "we include this as zone of stomach even though it is not distinguished by gland type" ; oboInOwl:hasDbXref "BTO:0000505", "EMAPA:35810", "FMA:14560", "MA:0002559", "NCIT:C12258", "SCTID:362140009", "UMLS:C0227230", "Wikipedia:Body_of_stomach", "galen:GastricCorpus" ; oboInOwl:hasExactSynonym "corpus gastricum (ventriculare)", "gastric body", "stomach body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpus gastricum", "corpus ventriculare", "corpus ventriculi", "gastric corpus" ; oboInOwl:id "UBERON:0001161" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "body of stomach" ; rdfs:subClassOf obo:UBERON_0009870 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg"^^xsd:anyURI . obo:UBERON_0001165 obo:IAO_0000115 "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." ; oboInOwl:hasBroadSynonym "antrum" ; oboInOwl:hasDbXref "BTO:0001732", "EFO:0002555", "EMAPA:17891", "FMA:14579", "GAID:332", "MA:0001624", "MESH:D011706", "NCIT:C12259", "SCTID:362142001", "UMLS:C0034193", "Wikipedia:Pyloric_antrum", "galen:PyloricAntrum" ; oboInOwl:hasExactSynonym "antrum of stomach", "stomach pyloric antrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "antrum of Willis", "antrum pylori", "antrum pyloricum", "gastric antrum", "stomach antrum" ; oboInOwl:id "UBERON:0001165" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pyloric antrum" ; rdfs:subClassOf obo:UBERON_0009870, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000502 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001161 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001166 ], _:genid114586 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg"^^xsd:anyURI . obo:UBERON_0001166 obo:IAO_0000115 "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." ; obo:IAO_0000116 "We follow Kardong in defining stomach regions by glands" ; obo:UBPROP_0000001 "The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; obo:UBPROP_0000007 "pyloric" ; oboInOwl:hasDbXref "BTO:0001146", "EHDAA2:0001580", "EHDAA:4860", "EMAPA:17631", "FMA:14581", "GAID:333", "MA:0002560", "MESH:D011708", "NCIT:C12260", "SCTID:362143006", "UMLS:C0034196", "VHOG:0000420", "Wikipedia:Pylorus", "galen:Pylorus" ; oboInOwl:hasExactSynonym "pars pylorica", "pars pylorica gastricae", "pyloric part of stomach", "pyloric region", "stomach pyloric region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "valvula pylori" ; oboInOwl:id "UBERON:0001166" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pylorus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009870 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001165 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0008858 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0008861 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg"^^xsd:anyURI . obo:UBERON_0001167 obo:IAO_0000115 "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." ; oboInOwl:hasDbXref "EMAPA:35826", "FMA:14582", "MA:0002692", "SCTID:279995000", "galen:WallOfStomach" ; oboInOwl:hasExactSynonym "anatomical wall of stomach", "anatomical wall of ventriculus", "gastric wall", "stomach anatomical wall", "stomach wall", "ventriculus anatomical wall", "ventriculus wall", "wall of ventriculus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001167" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "wall of stomach" ; rdfs:subClassOf obo:UBERON_0000060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0001168 obo:IAO_0000115 "An anatomical wall that is part of a small intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35785", "FMA:14615", "MA:0002696", "NCIT:C33573", "UMLS:C1519375" ; oboInOwl:hasExactSynonym "anatomical wall of small bowel", "anatomical wall of small intestine", "small bowel anatomical wall", "small bowel wall", "small intestinal wall", "small intestine anatomical wall", "small intestine wall", "wall of small bowel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001168" ; a owl:Class ; rdfs:label "wall of small intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 _:genid114437 ) ] . obo:UBERON_0001169 obo:IAO_0000115 "An anatomical wall that is part of a large intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35470", "FMA:14619", "MA:0002695" ; oboInOwl:hasExactSynonym "anatomical wall of large intestine", "large intestinal wall", "large intestine anatomical wall", "large intestine wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001169" ; a owl:Class ; rdfs:label "wall of large intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0001170 obo:IAO_0000115 "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." ; oboInOwl:hasDbXref "EMAPA:37745", "FMA:14643", "MA:0001555", "SCTID:245456008", "Wikipedia:Mesentery#Mesentery_.28proper.29" ; oboInOwl:hasExactSynonym "mesentery (proper)", "mesentery proper", "small intestinal mesentery", "small intestine mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001170" ; a owl:Class ; rdfs:label "mesentery of small intestine" ; rdfs:subClassOf obo:UBERON_0007826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001171 obo:IAO_0000115 "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." ; oboInOwl:hasDbXref "FMA:14653", "MA:0002498", "NCIT:C33341", "UMLS:C0682620" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001171" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "portal lobule" ; rdfs:subClassOf obo:UBERON_0009911, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001280 ], _:genid114659 . obo:UBERON_0001172 obo:IAO_0000115 "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." ; oboInOwl:hasDbXref "EMAPA:35497", "FMA:14654", "MA:0002496", "NCIT:C32992", "SCTID:272214009", "UMLS:C0227519" ; oboInOwl:hasExactSynonym "liver acinus", "portal acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001172" ; a owl:Class ; rdfs:label "hepatic acinus" ; rdfs:subClassOf obo:UBERON_0009842, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001171 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0004647 ], _:genid114665 . obo:UBERON_0001173 obo:IAO_0000115 "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." ; obo:RO_0002171 obo:UBERON_0002110 ; obo:UBPROP_0000001 "Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO]" ; oboInOwl:hasDbXref "AAO:0011020", "EMAPA:35172", "FMA:14665", "SCTID:181267003", "UMLS:C0005423", "Wikipedia:Biliary_tract", "XAO:0000455" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary tract" ; oboInOwl:id "UBERON:0001173" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP]" ; rdfs:label "biliary tree" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001246 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001282 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004912 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002423 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid114477 ] . obo:UBERON_0001174 obo:IAO_0000115 "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." ; obo:UBPROP_0000001 "Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO]", "The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000303", "EHDAA:3981", "EMAPA:17201", "FMA:14667", "GAID:282", "MA:0001631", "MESH:D003135", "NCIT:C12698", "SCTID:362199009", "TAO:0005165", "UMLS:C0009437", "VHOG:0000214", "Wikipedia:Common_bile_duct", "ZFA:0005165", "galen:CommonBileDuct" ; oboInOwl:hasExactSynonym "ductus choledochus (biliaris)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus choledochus" ; oboInOwl:id "UBERON:0001174" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "common bile duct" ; rdfs:subClassOf obo:UBERON_0003703, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001152 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001175 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001970 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001064 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png"^^xsd:anyURI . obo:UBERON_0001175 obo:IAO_0000115 "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." ; obo:IAO_0000116 "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part" ; obo:UBPROP_0000001 "The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; oboInOwl:hasDbXref "EMAPA:19101", "FMA:14668", "GAID:286", "MA:0002660", "MESH:D006500", "NCIT:C32356", "SCTID:245403006", "UMLS:C0019149", "VHOG:0000220", "Wikipedia:Common_hepatic_duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus hepaticus communis", "hepatic duct" ; oboInOwl:id "UBERON:0001175" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "common hepatic duct" ; rdfs:subClassOf obo:UBERON_0003703, [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001970 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001174 ], _:genid114697, _:genid114699, _:genid114701, _:genid114703 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg"^^xsd:anyURI . obo:UBERON_0001176 obo:IAO_0000115 "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." ; obo:UBPROP_0000001 "The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001727", "EHDAA:3992", "EMAPA:32797", "FMA:14669", "MA:0001639", "NCIT:C33476", "SCTID:245401008", "UMLS:C0227557", "VHOG:0000217" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus hepaticus dexter" ; oboInOwl:id "UBERON:0001176" ; a owl:Class ; rdfs:label "right hepatic duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005171 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003703 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001114 ] ) ] . obo:UBERON_0001177 obo:IAO_0000115 "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." ; obo:UBPROP_0000001 "The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000941", "EHDAA:3990", "EMAPA:32795", "FMA:14670", "MA:0001638", "NCIT:C32960", "SCTID:245400009", "UMLS:C0227560", "VHOG:0000218" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus hepaticus sinister" ; oboInOwl:id "UBERON:0001177" ; a owl:Class ; rdfs:label "left hepatic duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005171 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003703 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001115 ] ) ] . obo:UBERON_0001178 obo:IAO_0000115 "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." ; oboInOwl:hasDbXref "EMAPA:16592", "FMA:14703", "SCTID:362702003", "TAO:0005132", "VHOG:0001528", "Wikipedia:Visceral_peritoneum", "ZFA:0005132" ; oboInOwl:hasExactSynonym "visceral serous membrane of peritoneum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001178" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "visceral peritoneum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022350 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png"^^xsd:anyURI . obo:UBERON_0001179 obo:IAO_0000115 "Anatomical cavity bounded by visceral and parietal peritoneum." ; obo:UBPROP_0000001 "The potential space between the parietal and visceral layers of the peritoneum, which are normally in contact. The peritoneal cavity is divided into the greater and lesser sac. The greater sac is the peritoneal cavity, and the lesser sac is the omental bursa. [TFD][VHOG]" ; obo:UBPROP_0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001782", "EHDAA2:0001446", "EMAPA:16138", "FMA:14704", "GAID:24", "MA:0000054", "MESH:D010529", "NCIT:C12769", "SCTID:181616008", "UMLS:C1704247", "VHOG:0000852", "Wikipedia:Peritoneal_cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas peritonealis", "saccus serosus peritonei" ; oboInOwl:id "UBERON:0001179" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "peritoneal cavity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035820 ], _:genid114744 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001178 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001366 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0035820 ] ) ] . obo:UBERON_0001182 obo:IAO_0000115 "Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra." ; obo:UBPROP_0000010 "Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon" ; oboInOwl:hasDbXref "BTO:0002303", "EHDAA2:0001949", "EHDAA:3358", "EHDAA:5313", "EMAPA:18619", "FMA:14749", "GAID:502", "MA:0002005", "MESH:D017538", "NCIT:C33685", "SCTID:362048004", "UMLS:C0162861", "VHOG:0000754", "Wikipedia:Superior_mesenteric_artery", "galen:SuperiorMesentericArtery" ; oboInOwl:hasExactSynonym "superior mesenteric arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria mesenterica superior" ; oboInOwl:id "UBERON:0001182" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "superior mesenteric artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005616 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray1099.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c0/Superior_mesenteric_a.gif"^^xsd:anyURI . obo:UBERON_0001183 obo:IAO_0000115 "Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "IMA" ; oboInOwl:hasDbXref "BTO:0002302", "EHDAA2:0000817", "EHDAA:4345", "EMAPA:18618", "FMA:14750", "GAID:501", "MA:0002004", "MESH:D017537", "NCIT:C32780", "SCTID:181341006", "UMLS:C0162860", "VHOG:0001116", "Wikipedia:Inferior_mesenteric_artery", "galen:InferiorMesentericArtery" ; oboInOwl:hasExactSynonym "inferior mesenteric arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria mesenterica inferior" ; oboInOwl:id "UBERON:0001183" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "inferior mesenteric artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005616 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001052 ] _:genid114566 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e4/Gray538.png"^^xsd:anyURI . obo:UBERON_0001184 obo:IAO_0000115 "One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates." ; obo:IAO_0000116 "renal arteries vary widely even in humans. Sub-structures should be checked for taxon variability." ; obo:UBPROP_0000001 "Artery which supplies blood via branches to the gonads, oviducts, and kidneys.[AAO]", "The renal arteries normally arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood. Each is directed across the crus of the diaphragm, so as to form nearly a right angle with the aorta. The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys. The arterial supply of the kidneys is variable and there may be one or more renal arteries supplying each kidney. It is located above the renal vein. It has a radius of approximately 0.25cm, 0.26 cm at the root. The measured mean diameter can differ depending on the imaging method used. For example, the diameter was found to be 5.04 ± 0.74 mm using ultrasound, but 5.68 ± 1.19 mm using angiography. [WP,unvetted].[Wikipedia]" ; oboInOwl:hasDbXref "AAO:0010223", "BTO:0001165", "EFO:0002552", "EHDAA2:0004100", "EHDAA:5321", "EHDAA:8594", "EMAPA:28373", "FMA:14751", "GAID:507", "MA:0002035", "MESH:D012077", "NCIT:C12778", "RETIRED_EHDAA2:0001600", "SCTID:181339005", "TAO:0000420", "UMLS:C0035065", "Wikipedia:Renal_artery", "ZFA:0000420", "galen:RenalArtery" ; oboInOwl:hasExactSynonym "renal arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria renalis", "renal arteries" ; oboInOwl:id "UBERON:0001184" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "renal artery" ; rdfs:subClassOf obo:UBERON_0004573, _:genid114778 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png"^^xsd:anyURI . obo:UBERON_0001185 obo:IAO_0000115 "Renal artery that supplies the right kidney." ; oboInOwl:hasDbXref "EMAPA:37380", "FMA:14752", "MA:0002037", "NCIT:C52740", "SCTID:36800007", "UMLS:C0226332" ; oboInOwl:hasExactSynonym "right renal arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001185" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The right [renal artery] passes behind the inferior vena cava, the right renal vein, the head of the pancreas, and the descending part of the duodenum[WP]" ; rdfs:label "right renal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid114586 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png"^^xsd:anyURI . obo:UBERON_0001186 obo:IAO_0000115 "Renal artery that supplies the left kidney." ; oboInOwl:hasDbXref "EMAPA:37098", "FMA:14753", "MA:0002036", "NCIT:C52741", "SCTID:19215005", "UMLS:C0226333" ; oboInOwl:hasExactSynonym "left renal arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001186" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "The left [renal artery] is somewhat higher than the right; it lies behind the left renal vein, the body of the pancreas and the splenic vein, and is crossed by the inferior mesenteric vein[WP]" ; rdfs:label "left renal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001184 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004538 ] ) ] . obo:UBERON_0001187 obo:IAO_0000115 "One of a pair of arteries that is a branch of the abdominal aorta that supplies blood to a male gonad." ; oboInOwl:hasDbXref "EMAPA:18621", "FMA:14758", "MA:0002063", "SCTID:244281003", "Wikipedia:Testicular_artery" ; oboInOwl:hasExactSynonym "testicular arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria testicularis", "internal spermatic", "internal spermatic arteries", "internal spermatic artery", "internal spermatic vessels", "spermatic arteries", "spermatic artery", "spermatic vessels", "testicular arteries" ; oboInOwl:id "UBERON:0001187" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "testicular artery" ; rdfs:subClassOf _:genid114804 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png"^^xsd:anyURI . obo:UBERON_0001188 obo:IAO_0000115 "A testicular artery that supplies a right testicle." ; oboInOwl:hasDbXref "EMAPA:37382", "FMA:14759", "MA:0002042", "NCIT:C52738", "UMLS:C0734076" ; oboInOwl:hasExactSynonym "right spermatic artery", "trunk of right testicular arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001188" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right testicular artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001222 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001187 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004534 ] ) ] . obo:UBERON_0001189 obo:IAO_0000115 "A testicular artery that supplies a left testicle." ; oboInOwl:hasDbXref "EMAPA:37099", "FMA:14760", "MA:0002041", "NCIT:C52739", "UMLS:C0734077" ; oboInOwl:hasExactSynonym "left spermatic artery", "trunk of left testicular arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001189" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left testicular artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001223 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001187 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004533 ] ) ] . obo:UBERON_0001190 obo:IAO_0000115 "An artery that supplies an ovary." ; obo:UBPROP_0000001 "In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]." ; oboInOwl:hasDbXref "EMAPA:18620", "FMA:14761", "MA:0002012", "NCIT:C33242", "SCTID:244280002", "UMLS:C0226411", "Wikipedia:Ovarian_artery" ; oboInOwl:hasExactSynonym "ovarian arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria ovarica" ; oboInOwl:id "UBERON:0001190" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "ovarian artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001516 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png"^^xsd:anyURI . obo:UBERON_0001191 obo:IAO_0000115 "The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0000311", "EHDAA:2553", "EMAPA:17310", "FMA:14764", "MA:0001972", "NCIT:C32357", "SCTID:362050007", "UMLS:C1261084", "Wikipedia:Common_iliac_artery" ; oboInOwl:hasExactSynonym "common iliac arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria iliaca communis" ; oboInOwl:id "UBERON:0001191" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "See notes for parent class" ; rdfs:label "common iliac artery" ; rdfs:subClassOf obo:UBERON_0005609, _:genid114842 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Iliac_artery_bifurcation_and_aorta.PNG"^^xsd:anyURI . obo:UBERON_0001193 obo:IAO_0000115 "An artery that supplies the liver." ; obo:IAO_0000232 "currently defined in a generic fashion." ; obo:UBPROP_0000001 "Artery that supplies blood to the liver.[TAO]" ; oboInOwl:hasDbXref "BTO:0004307", "EMAPA:17859", "FMA:14769", "GAID:496", "MA:0001963", "MESH:D006499", "NCIT:C32729", "SCTID:76015000", "TAO:0005161", "UMLS:C0019145", "ZFA:0005161", "galen:HepaticArtery" ; oboInOwl:hasExactSynonym "arteria hepatica propria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria hepatica" ; oboInOwl:id "UBERON:0001193" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatic artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png"^^xsd:anyURI . obo:UBERON_0001194 obo:IAO_0000115 "An artery that supplies the spleen." ; oboInOwl:hasDbXref "EMAPA:19216", "FMA:14773", "GAID:510", "MA:0001991", "MA:0003177", "MESH:D013157", "NCIT:C33597", "SCTID:244266009", "UMLS:C0037996", "Wikipedia:Splenic_artery", "galen:SplenicArtery" ; oboInOwl:hasExactSynonym "arteria splenica", "lienal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria lienalis" ; oboInOwl:id "UBERON:0001194" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "splenic artery" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/268"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001640 ] ; owl:disjointWith obo:UBERON_0001640 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png"^^xsd:anyURI . obo:UBERON_0001199 obo:IAO_0000115 "The mucosal layer that lines the stomach." ; obo:UBPROP_0000001 "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]." ; oboInOwl:hasDbXref "BTO:0001308", "CALOHA:TS-0404", "EMAPA:35817", "FMA:14907", "GAID:321", "MA:0002683", "MESH:D005753", "NCIT:C32656", "SCTID:362131005", "UMLS:C0017136", "Wikipedia:Gastric_mucosa", "galen:GastricMucosa" ; oboInOwl:hasExactSynonym "gastric mucosa", "gastric mucous membrane", "mucosa of organ of stomach", "mucosa of organ of ventriculus", "mucosa of ventriculus", "mucous membrane of stomach", "mucous membrane of ventriculus", "organ mucosa of stomach", "organ mucosa of ventriculus", "stomach mucosa", "stomach mucosa of organ", "stomach mucous membrane", "stomach organ mucosa", "tunica mucosa (gaster)", "tunica mucosa gastricae", "ventriculus mucosa", "ventriculus mucosa of organ", "ventriculus mucous membrane", "ventriculus organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Magenschleimhaut", "tunica mucosa gastris" ; oboInOwl:id "UBERON:0001199" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mucosa of stomach" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001696 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001167 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 _:genid114665 ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg"^^xsd:anyURI . obo:UBERON_0001200 obo:IAO_0000115 "The fibrous connective tissue layer beneath the stomach mucosa." ; oboInOwl:hasDbXref "BTO:0002110", "EMAPA:35825", "FMA:14908", "MA:0002685", "NCIT:C32663", "SCTID:52459002", "UMLS:C0227211" ; oboInOwl:hasExactSynonym "gastric submucosa", "stomach submucosa", "submucosa of ventriculus", "tela submucosa (gaster)", "tela submucosa gastricae", "ventriculus submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of stomach", "tela submucosa ventriculi" ; oboInOwl:id "UBERON:0001200" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "submucosa of stomach" ; rdfs:subClassOf obo:UBERON_0000009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001167 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0001201 obo:IAO_0000115 "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." ; obo:IAO_0000116 "TODO - check serosa/peritoneum" ; oboInOwl:hasDbXref "EMAPA:35822", "FMA:14914", "MA:0001626", "NCIT:C32662", "SCTID:1353004", "UMLS:C1517453" ; oboInOwl:hasExactSynonym "anatomical wall of stomach serosa", "anatomical wall of stomach serous membrane", "anatomical wall of ventriculus serosa", "anatomical wall of ventriculus serous membrane", "gastric wall serosa", "gastric wall serous membrane", "serosa of anatomical wall of stomach", "serosa of anatomical wall of ventriculus", "serosa of gastric wall", "serosa of stomach anatomical wall", "serosa of stomach wall", "serosa of ventriculus anatomical wall", "serosa of ventriculus wall", "serosa of wall of stomach", "serosa of wall of ventriculus", "serous coat of stomach", "serous membrane of anatomical wall of stomach", "serous membrane of anatomical wall of ventriculus", "serous membrane of gastric wall", "serous membrane of stomach anatomical wall", "serous membrane of stomach wall", "serous membrane of ventriculus anatomical wall", "serous membrane of ventriculus wall", "serous membrane of wall of stomach", "serous membrane of wall of ventriculus", "stomach anatomical wall serosa", "stomach anatomical wall serous membrane", "stomach serosa", "stomach wall serosa", "stomach wall serous membrane", "tunica serosa (gaster)", "tunica serosa gastricae", "ventriculus anatomical wall serosa", "ventriculus anatomical wall serous membrane", "ventriculus wall serosa", "ventriculus wall serous membrane", "visceral peritoneum of stomach", "wall of stomach serosa", "wall of stomach serous membrane", "wall of ventriculus serosa", "wall of ventriculus serous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric serosa" ; oboInOwl:id "UBERON:0001201" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "serosa of stomach" ; rdfs:subClassOf obo:UBERON_0000042, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001167 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid114703 ] . obo:UBERON_0001202 obo:IAO_0000115 "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." ; obo:RO_0002161 obo:NCBITaxon_8355 ; obo:UBPROP_0000003 "(...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG]" ; oboInOwl:hasDbXref "AAO:0011093", "EMAPA:19251", "FMA:14916", "MA:0002952", "NCIT:C33433", "SCTID:268073008", "UMLS:C0227238", "VHOG:0001466", "XAO:0000457" ; oboInOwl:hasExactSynonym "pyloric valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001202" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pyloric sphincter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0008858 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002114 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001166 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001166 ] ) ] . obo:UBERON_0001204 obo:IAO_0000115 "A mucosa that is part of a small intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001259", "CALOHA:TS-0941", "EMAPA:35780", "FMA:14933", "MA:0002686", "NCIT:C33568", "SCTID:362144000", "UMLS:C0227261" ; oboInOwl:hasExactSynonym "mucosa of organ of small bowel", "mucosa of organ of small intestine", "mucosa of small bowel", "mucous membrane of small bowel", "mucous membrane of small intestine", "organ mucosa of small bowel", "organ mucosa of small intestine", "small bowel mucosa", "small bowel mucosa of organ", "small bowel mucous membrane", "small bowel organ mucosa", "small intestinal mucosa", "small intestine mucosa", "small intestine mucosa of organ", "small intestine mucous membrane", "small intestine organ mucosa", "tunica mucosa (intestinum tenue)", "tunica mucosa intestini tenuis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001204" ; a owl:Class ; rdfs:label "mucosa of small intestine" ; rdfs:subClassOf obo:UBERON_0001242, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001205 obo:IAO_0000115 "Submucosal tissue in the small intestines." ; oboInOwl:hasDbXref "BTO:0002112", "EMAPA:37564", "FMA:14934", "MA:0001562", "NCIT:C33572", "SCTID:691000", "UMLS:C0227268", "Wikipedia:Small_intestinal_submucosa" ; oboInOwl:hasExactSynonym "small bowel submucosa", "small intestinal submucosa", "small intestine submucosa", "submucosa of small bowel", "tela submucosa (intestinum tenue)", "tela submucosa intestini tenuis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001205" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "submucosa of small intestine" ; rdfs:subClassOf obo:UBERON_0000009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001206 obo:IAO_0000115 "A serous membrane that is part of a small intestine [Automatically generated definition]." ; obo:UBPROP_0000010 "duodenum, 1st part serosa, 2nd - 4th adventitia" ; oboInOwl:hasDbXref "EMAPA:37561", "FMA:14938", "MA:0001558", "SCTID:8266009" ; oboInOwl:hasExactSynonym "serosa of small bowel", "serous coat of small intestine", "serous membrane of small bowel", "serous membrane of small intestine", "small bowel serosa", "small bowel serous membrane", "small intestinal serosa", "small intestine serosa", "small intestine serous membrane", "tunica serosa (intestinum tenue)", "tunica serosa intestini tenuis", "visceral peritoneum of small intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001206" ; a owl:Class ; rdfs:label "serosa of small intestine" ; rdfs:subClassOf obo:UBERON_0001243, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001207 obo:IAO_0000115 "A mucosa that is part of a large intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-2106", "EMAPA:35467", "FMA:14969", "MA:0002688", "NCIT:C32926", "UMLS:C0734203" ; oboInOwl:hasExactSynonym "large intestinal mucosa", "large intestine mucosa", "large intestine mucosa of organ", "large intestine mucous membrane", "large intestine organ mucosa", "mucosa of organ of large intestine", "mucous membrane of large intestine", "organ mucosa of large intestine", "tunica mucosa intestini crassi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001207" ; a owl:Class ; rdfs:label "mucosa of large intestine" ; rdfs:subClassOf obo:UBERON_0001242, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001169 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0001208 obo:IAO_0000115 "A submucosa that is part of a large intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0002111", "EMAPA:37560", "FMA:14970", "MA:0002690", "NCIT:C32930", "UMLS:C0734204" ; oboInOwl:hasExactSynonym "large intestinal submucosa", "large intestine submucosa", "tela submucosa intestini crassi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of large intestine" ; oboInOwl:id "UBERON:0001208" ; a owl:Class ; rdfs:label "submucosa of large intestine" ; rdfs:subClassOf obo:UBERON_0000009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001169 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0001209 obo:IAO_0000115 "A serous membrane that is part of a large intestine [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check serosa/peritoneum" ; oboInOwl:hasDbXref "EMAPA:37557", "FMA:14975", "MA:0001546", "NCIT:C32929", "UMLS:C1517727" ; oboInOwl:hasExactSynonym "large intestinal serosa", "large intestine serosa", "large intestine serous membrane", "serous coat of large intestine", "serous membrane of large intestine", "tunica serosa intestini crassi", "visceral peritoneum of large intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001209" ; a owl:Class ; rdfs:label "serosa of large intestine" ; rdfs:subClassOf obo:UBERON_0001243, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001169 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001243 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0001212 obo:IAO_0000115 "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." ; obo:IAO_0000116 "currently defined as equivalent to any submucosal gland in the duodenum." ; obo:UBPROP_0000008 "Said to be absent outside mammlian (Andrew 1959) but Ziswiler and Farner (1972) noted similar glands at the gastroduodenal junction of some birds" ; oboInOwl:hasDbXref "BTO:0002376", "EMAPA:36522", "FMA:15060", "GAID:314", "MA:0001551", "MESH:D002011", "NCIT:C13010", "SCTID:41298001", "UMLS:C0006323", "Wikipedia:Brunner's_glands" ; oboInOwl:hasExactSynonym "Brunner's gland", "gland of Brunner", "submucosal gland of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula duodenales", "glandula duodenales Brunneri" ; oboInOwl:id "UBERON:0001212" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "duodenal gland" ; rdfs:subClassOf obo:UBERON_0000414, obo:UBERON_0011148, [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0000912 ], _:genid115050, _:genid115052 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid114842 ] . obo:UBERON_0001213 obo:IAO_0000115 "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." ; obo:IAO_0000116 "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine" ; obo:UBPROP_0000001 "The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO]" ; obo:UBPROP_0000012 "the BTO class refers to a generic villous" ; oboInOwl:hasAlternativeId "UBERON:0007607" ; oboInOwl:hasDbXref "BTO:0003121", "EMAPA:35784", "FMA:15072", "MA:0001563", "NCIT:C33874", "SCTID:23230007", "TAO:0005125", "UMLS:C1519988", "Wikipedia:Intestinal_villus", "ZFA:0005125" ; oboInOwl:hasExactSynonym "enteric villi", "enteric villous", "enteric villus", "intestinal villi", "villi intestinales", "villus", "villus intestinalis (intestinum tenue)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal villus layer", "small intestine villus", "villi intestinales" ; oboInOwl:id "UBERON:0001213" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intestinal villus" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000066 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001981 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0012425 ], _:genid115063 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg"^^xsd:anyURI . obo:UBERON_0001215 obo:IAO_0000115 "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0002782", "EHDAA2:0000819", "EHDAA:8712", "EMAPA:18642", "FMA:15391", "MA:0002178", "NCIT:C32782", "SCTID:281055007", "UMLS:C0226754", "VHOG:0001118", "Wikipedia:Inferior_mesenteric_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower mesenteric vein", "vena mesenterica inferior" ; oboInOwl:id "UBERON:0001215" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "inferior mesenteric vein" ; rdfs:subClassOf _:genid115085 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005617 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png"^^xsd:anyURI . obo:UBERON_0001216 obo:IAO_0000115 "A tributary of the superior mesenteric vein that drains the jejunum." ; oboInOwl:hasDbXref "EMAPA:37160", "FMA:15402", "MA:0002153", "Wikipedia:Jejunal_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae jejunales" ; oboInOwl:id "UBERON:0001216" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal vein" ; rdfs:subClassOf obo:UBERON_0002017, _:genid115096 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png"^^xsd:anyURI . obo:UBERON_0001217 obo:IAO_0000115 "The veins that drain blood from the ileum into the superior mesenteric vein." ; oboInOwl:hasDbXref "EMAPA:37149", "FMA:15405", "MA:0002140", "NCIT:C53046", "UMLS:C1301431", "Wikipedia:Ileal_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001217" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ileal vein" ; rdfs:subClassOf obo:UBERON_0002017, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001138 ], _:genid115106 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0001221 obo:IAO_0000115 "The lateral abdominal wall muscle that is deep to the internal oblique." ; obo:UBPROP_0000001 "One of a pair of transverse abdominal muscles that is the anterolateral muscle of the abdomen, lying immediately under the internal abdominal oblique. [TFD][VHOG]" ; obo:UBPROP_0000003 "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0002078", "EHDAA:8254", "EMAPA:18165", "FMA:15570", "MA:0002396", "NCIT:C53179", "SCTID:244949003", "UMLS:C0224378", "VHOG:0000845", "Wikipedia:Transversus_abdominis_muscle" ; oboInOwl:hasExactSynonym "musculus transversus abdominis", "transverse abdominal", "transversis abdominus", "transversus abdominis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "transversalis", "transversalis muscle", "transverse abdominal", "transverse abdominal muscle", "transverse abdominis", "transverse abdominus", "transversus", "transversus abdominis", "transversus abdominus", "transversus abdominus muscle" ; oboInOwl:id "UBERON:0001221" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:label "transversus abdominis muscle" ; rdfs:subClassOf obo:UBERON_0002461, _:genid115118 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0005454 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/32/Illu_trunk_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001222 obo:IAO_0000115 "An ureter that is part of a right side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37373", "FMA:15571", "MA:0001685", "NCIT:C49327", "SCTID:276251000", "UMLS:C0227682" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001222" ; a owl:Class ; rdfs:label "right ureter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000056 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0001223 obo:IAO_0000115 "An ureter that is part of a left side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37372", "FMA:15572", "MA:0001684", "NCIT:C49324", "SCTID:276340002", "UMLS:C0227683" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001223" ; a owl:Class ; rdfs:label "left ureter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000056 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0001224 obo:IAO_0000115 "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." ; oboInOwl:hasDbXref "CALOHA:TS-2230", "EMAPA:17948", "FMA:15575", "GAID:426", "MA:0000374", "MESH:D007682", "NCIT:C12887", "SCTID:362221007", "UMLS:C0227666", "Wikipedia:Renal_pelvis", "galen:RenalPelvis" ; oboInOwl:hasExactSynonym "kidney pelvis", "pelvis of ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "p. renallis", "pyelum" ; oboInOwl:id "UBERON:0001224" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "In this ontology, the renal pelvis is represented as the area of part-overlap between the kidney and the ureter" ; rdfs:label "renal pelvis" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036295 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000056 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001088 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0002113 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0000056 ], _:genid115152, _:genid115155 ; owl:disjointWith obo:UBERON_0002355 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg"^^xsd:anyURI . obo:UBERON_0001225 obo:IAO_0000115 "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." ; obo:UBPROP_0000010 "In the adult metanephros, it forms a continuous smooth outer zone with a number of projections that extend down between the pyramids. It contains the renal corpuscles and the renal tubules except for parts of the loop of Henle which descend into the renal medulla. It also contains blood vessels and cortical collecting ducts. The renal cortex is the part of the kidney where ultrafiltration occurs.[WP]" ; oboInOwl:hasDbXref "BTO:0001166", "CALOHA:TS-0503", "EMAPA:17952", "FMA:15581", "GAID:424", "MA:0000372", "MESH:D007672", "NCIT:C12739", "SCTID:362211004", "UMLS:C0022655", "Wikipedia:Renal_cortex", "galen:CortexOfKidney" ; oboInOwl:hasExactSynonym "cortex renalis", "kidney cortex", "renal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001225" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cortex of kidney" ; rdfs:subClassOf obo:UBERON_0001851, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid115169 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg"^^xsd:anyURI . obo:UBERON_0001228 obo:IAO_0000115 "Tip of renal pyramid projecting into a minor calyx." ; oboInOwl:hasDbXref "BTO:0003925", "EMAPA:35727", "FMA:15622", "MA:0002730", "MESH:D007679", "NCIT:C33460", "SCTID:362214007", "UMLS:C0022666", "Wikipedia:Renal_papilla", "galen:RenalPapilla" ; oboInOwl:hasExactSynonym "kidney papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001228" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "renal papilla" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001224 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png"^^xsd:anyURI . obo:UBERON_0001229 obo:IAO_0000115 "The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron." ; obo:UBPROP_0000001 "A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney[BTO]", "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated. Paired highly vascularized structures of the pronephros, responsible for blood filtration.[XAO]", "The part of the nephron that filters blood.[TAO]" ; oboInOwl:hasDbXref "BTO:0000333", "CALOHA:TS-1317", "EMAPA:28236", "EMAPA:35726", "EV:0100385", "FMA:15625", "MA:0000376", "NCIT:C33456", "SCTID:361329009", "TAO:0005281", "UMLS:C0227635", "VHOG:0001262", "Wikipedia:Renal_corpuscle", "ZFA:0005281" ; oboInOwl:hasExactSynonym "Malphigian corpuscle", "Malpighian corpuscle", "corpusculum renale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpusculum renis", "cortical renal corpuscle", "kidney corpuscle" ; oboInOwl:id "UBERON:0001229" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Together, the Bowmans capsule and the glomerulus comprise the definitive renal corpuscle. http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; rdfs:label "renal corpuscle" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001285 ], _:genid115182, _:genid115184 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg"^^xsd:anyURI . obo:UBERON_0001230 obo:IAO_0000115 "A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus." ; obo:UBPROP_0000001 "Anatomical structure found in the kidney consisting of an expanded end of a kidney tubule surrounding a glomerulus and is the major site of filtration.[AAO]" ; obo:UBPROP_0000009 "Fluids from blood in the glomerulus are collected in the Bowman's capsule and further processed along the nephron to form urine. This process is known as ultrafiltration[WP]." ; obo:UBPROP_0000011 "One fold of the S-shaped body gives rise to Bowman's capsule[GUDMAP]" ; oboInOwl:hasDbXref "AAO:0010526", "BTO:0002297", "EMAPA:27973", "EMAPA:28257", "FMA:15626", "KUPO:0001001", "MA:0001660", "NCIT:C32225", "SCTID:361331000", "TAO:0005254", "TAO:0005310", "UMLS:C0524448", "Wikipedia:Bowman%27s_capsule", "ZFA:0005254", "ZFA:0005310" ; oboInOwl:hasExactSynonym "Bowman's capsule", "Bowmans capsule", "capsula glomerularis", "renal glomerular capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Bowman's capsule", "Malphigian capsule", "Malpighian capsule", "Mueller capsule", "Muellerian capsule", "capsula glomeruli", "pronephric glomerular capsule" ; oboInOwl:id "UBERON:0001230" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "glomerular capsule" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004199 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001229 ], _:genid115201 ; owl:disjointWith obo:UBERON_0002015 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg"^^xsd:anyURI . obo:UBERON_0001231 obo:IAO_0000115 "An epithelial tube that is part of the nephron, the functional part of the kidney." ; obo:UBPROP_0000012 "note that in ISBN:0073040584 (Vertebrates, Kardong), the uriniferous tubule contains the nephron, so we have a separate class, rather than using a synonym, as in MA" ; oboInOwl:hasAlternativeId "UBERON:0004210" ; oboInOwl:hasBroadSynonym "renal tubule" ; oboInOwl:hasDbXref "BTO:0000343", "CALOHA:TS-1262", "EFO:0003666", "EMAPA:27782", "EV:0100387", "FMA:15627", "GAID:433", "MA:0000377", "MESH:D007684", "NCIT:C49274", "SCTID:361332007", "TAO:0001287", "UMLS:C0022674", "Wikipedia:Renal_tubule", "ZFA:0001287" ; oboInOwl:hasExactSynonym "kidney tubule", "tubulus renalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "uriniferous tubule" ; oboInOwl:id "UBERON:0001231" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nephron tubule" ; rdfs:subClassOf obo:UBERON_0009773, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001285 ], _:genid115224, _:genid115226 ; owl:equivalentClass _:genid115218 . obo:UBERON_0001232 obo:IAO_0000115 "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient." ; obo:UBPROP_0000001 "Renal duct that collects the output from renal tubules.[TAO]" ; obo:UBPROP_0000012 "in ISBN:0073040584 (Vertebrates, Kardong), the nephron is adjacent to the collecting tubule, consistent with FMA, but not GO. Wikipedia says: Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron" ; oboInOwl:hasDbXref "BTO:0000761", "CALOHA:TS-0860", "EMAPA:28407", "EV:0100391", "FMA:15628", "GAID:434", "MA:0000371", "MESH:D007685", "SCTID:28202009", "TAO:0005294", "Wikipedia:Collecting_tubule", "ZFA:0005294" ; oboInOwl:hasExactSynonym "collecting duct", "kidney collecting duct", "renal collecting tubule", "tubulus renalis arcuatus", "tubulus renalis colligens" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcuate renal tubule", "collecting duct system", "collecting tubule", "junctional tube", "kidney collecting tubule", "ureteric tree" ; oboInOwl:id "UBERON:0001232" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "collecting duct of renal tubule" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004100 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid115234, _:genid115237 . obo:UBERON_0001233 obo:IAO_0000115 "An adrenal gland that is in the right side of the abdomen." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In humans, the right adrenal gland is triangular shaped" ; oboInOwl:hasDbXref "EMAPA:37357", "FMA:15629", "MA:0000719", "NCIT:C49325", "SCTID:281625001", "UMLS:C0229559" ; oboInOwl:hasExactSynonym "glandula suprarenalis dexter", "right suprarenal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001233" ; a owl:Class ; rdfs:label "right adrenal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002369 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0001234 obo:IAO_0000115 "An adrenal gland that is in the left side of the abdomen." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In humans, the left adrenal gland is semilunar shaped" ; oboInOwl:hasDbXref "EMAPA:37356", "FMA:15630", "MA:0000718", "NCIT:C49322", "SCTID:281626000", "UMLS:C0229560" ; oboInOwl:hasExactSynonym "glandula suprarenalis sinister", "left suprarenal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001234" ; a owl:Class ; rdfs:label "left adrenal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002369 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0001235 obo:IAO_0000115 "The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone." ; obo:UBPROP_0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" ; obo:UBPROP_0000008 "Kardong states that mammals are the first to have distinct cortext and medulla, but this contradicts XAO" ; oboInOwl:hasDbXref "AAO:0011009", "BTO:0000045", "CALOHA:TS-0015", "EFO:0000237", "EMAPA:18427", "EV:0100136", "FMA:15632", "GAID:447", "MA:0000118", "MAT:0000494", "MESH:D000302", "NCIT:C12396", "SCTID:362584002", "UMLS:C0001613", "VHOG:0001481", "Wikipedia:Adrenal_cortex", "XAO:0000165" ; oboInOwl:hasExactSynonym "adrenal gland cortex", "cortex (glandula suprarenalis)", "cortex of adrenal gland", "cortex of suprarenal gland", "suprarenal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortex glandulae suprarenalis", "suprarenal" ; oboInOwl:id "UBERON:0001235" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "adrenal cortex" ; rdfs:subClassOf obo:UBERON_0001851, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ], _:genid115052, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006705 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002369 ], _:genid115273 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png"^^xsd:anyURI . obo:UBERON_0001236 obo:IAO_0000115 "The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine." ; obo:UBPROP_0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011010", "BTO:0000049", "CALOHA:TS-0018", "EFO:0000852", "EMAPA:18428", "EV:0100137", "FMA:15633", "GAID:451", "MA:0000119", "MAT:0000495", "MESH:D019439", "NCIT:C12397", "SCTID:362585001", "UMLS:C0001629", "VHOG:0001378", "Wikipedia:Adrenal_medulla", "XAO:0000166" ; oboInOwl:hasExactSynonym "adrenal gland medulla", "medulla (glandula suprarenalis)", "medulla glandulae suprarenalis", "medulla of adrenal gland", "medulla of suprarenal gland", "suprarenal medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal central medulla", "chromaffin cells", "medulla of glandula suprarenalis" ; oboInOwl:id "UBERON:0001236" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "adrenal medulla" ; rdfs:subClassOf obo:UBERON_0000958, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000426 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002369 ], _:genid115287, _:genid115289, _:genid115292, _:genid115294 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 _:genid115063 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png"^^xsd:anyURI . obo:UBERON_0001238 obo:IAO_0000115 "Lamina propria that is part_of the small intestine." ; oboInOwl:hasDbXref "EMAPA:35779", "FMA:15651", "MA:0001554", "NCIT:C49297", "SCTID:63588008", "UMLS:C1711325" ; oboInOwl:hasExactSynonym "lamina propria mucosa of small bowel", "lamina propria mucosa of small intestine", "lamina propria mucosae of small bowel", "lamina propria mucosae of small intestine", "lamina propria of mucosa of small intestine", "lamina propria of small bowel", "small bowel lamina propria", "small bowel lamina propria mucosa", "small bowel lamina propria mucosae", "small intestine lamina propria", "small intestine lamina propria mucosa", "small intestine lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001238" ; a owl:Class ; rdfs:label "lamina propria of small intestine" ; rdfs:subClassOf obo:UBERON_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001204 ], _:genid115307 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001242 obo:IAO_0000115 "Mucosal layer that lines the intestine." ; oboInOwl:hasDbXref "BTO:0000642", "EMAPA:35440", "FMA:15695", "GAID:296", "MA:0001537", "MESH:D007413", "NCIT:C49241", "SCTID:362080002", "UMLS:C0021839" ; oboInOwl:hasExactSynonym "bowel mucosa", "bowel mucosa of organ", "bowel mucous membrane", "bowel organ mucosa", "intestine mucosa", "intestine mucosa of organ", "intestine mucous membrane", "intestine organ mucosa", "mucosa of bowel", "mucosa of intestine", "mucosa of organ of bowel", "mucosa of organ of intestine", "mucous membrane of bowel", "mucous membrane of intestine", "organ mucosa of bowel", "organ mucosa of intestine", "tunica mucosa intestini" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001242" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "intestinal mucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001262 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 _:genid115096 ) ] . obo:UBERON_0001243 obo:IAO_0000115 "A serous membrane that is part of a wall of intestine [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check serosa/peritoneum" ; oboInOwl:hasDbXref "EMAPA:37619", "FMA:15701", "MA:0001538" ; oboInOwl:hasExactSynonym "anatomical wall of bowel serosa", "anatomical wall of bowel serous membrane", "anatomical wall of intestine serosa", "anatomical wall of intestine serous membrane", "bowel anatomical wall serosa", "bowel anatomical wall serous membrane", "bowel wall serosa", "bowel wall serous membrane", "intestinal serosa", "intestinal wall serosa", "intestinal wall serous membrane", "intestine anatomical wall serosa", "intestine anatomical wall serous membrane", "intestine serosa", "intestine wall serosa", "intestine wall serous membrane", "serosa of anatomical wall of bowel", "serosa of anatomical wall of intestine", "serosa of bowel anatomical wall", "serosa of bowel wall", "serosa of intestinal wall", "serosa of intestine anatomical wall", "serosa of intestine wall", "serosa of wall of bowel", "serosa of wall of intestine", "serous membrane of anatomical wall of bowel", "serous membrane of anatomical wall of intestine", "serous membrane of bowel anatomical wall", "serous membrane of bowel wall", "serous membrane of intestinal wall", "serous membrane of intestine anatomical wall", "serous membrane of intestine wall", "serous membrane of wall of bowel", "serous membrane of wall of intestine", "visceral peritoneum of intestine", "wall of bowel serosa", "wall of bowel serous membrane", "wall of intestine serosa", "wall of intestine serous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001243" ; a owl:Class ; rdfs:label "serosa of intestine" ; rdfs:subClassOf obo:UBERON_0000042, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001262 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0001245 obo:IAO_0000115 "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." ; obo:UBPROP_0000007 "anal" ; obo:UBPROP_0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" ; oboInOwl:hasDbXref "BTO:0001680", "CALOHA:TS-2005", "EV:0100082", "FBbt:00047153", "FMA:15711", "GAID:312", "MA:0000331", "NCIT:C43362", "SCTID:181262009", "TADS:0000066", "TGMA:0001279", "UMLS:C0003461", "WBbt:0005364", "Wikipedia:Anus", "galen:Anus" ; oboInOwl:hasExactSynonym "anal opening", "anal orifice", "opening of terminal part of digestive tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proctodeum" ; oboInOwl:id "UBERON:0001245" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "anus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000931 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001108 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif"^^xsd:anyURI . obo:UBERON_0001246 obo:IAO_0000115 "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." ; oboInOwl:hasDbXref "FMA:15767", "MA:0002668", "NCIT:C32827", "SCTID:83488001", "UMLS:C0227515", "Wikipedia:Interlobular_bile_ducts" ; oboInOwl:hasExactSynonym "interlobular ductule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001246" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interlobular bile duct" ; rdfs:subClassOf obo:UBERON_0003704, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004058 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0014719 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001279 ], _:genid115394 . obo:UBERON_0001247 obo:IAO_0000115 "A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP]." ; obo:UBPROP_0000012 "in FMA this is a subclass of mesentery. In MA it is a subclass of ligament, we infer and assert this is a nonskeletal ligament" ; oboInOwl:hasDbXref "EHDAA2:0000499", "EHDAA:4856", "EMAPA:18288", "FMA:15823", "MA:0001622", "NCIT:C32582", "SCTID:362705001", "UMLS:C0230240", "VHOG:0000355", "Wikipedia:Falciform_ligament" ; oboInOwl:hasExactSynonym "falciform ligament of liver", "ligamentum falciforme (hepatis)", "ligamentum falciforme hepatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001247" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "falciform ligament" ; rdfs:subClassOf obo:UBERON_0013139, _:genid115408, _:genid115410 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008845 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000309 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0001249 obo:IAO_0000115 "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur." ; oboInOwl:hasAlternativeId "UBERON:0003969" ; oboInOwl:hasDbXref "EMAPA:35804", "MA:0002672", "NCIT:C33602", "SCTID:35845000", "UMLS:C1519475" ; oboInOwl:hasExactSynonym "Malpighian body", "lymphatic follicle of spleen", "lymphoid follicle of spleen", "lymphoid nodule of spleen", "spleen B cell follicle", "spleen lymphoid follicle", "splenic B cell follicle", "splenic lymphatic follicle", "splenic lymphoid follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spleen lymphoid nodule" ; oboInOwl:id "UBERON:0001249" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spleen lymphoid follicle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0002319 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001959 ], _:genid115420, _:genid115422, _:genid115424 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000444 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0001250 obo:IAO_0000115 "The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation." ; oboInOwl:hasDbXref "CALOHA:TS-1263", "EMAPA:35806", "FMA:15844", "MA:0000756", "NCIT:C12992", "SCTID:27579002", "UMLS:C0229687", "Wikipedia:Red_pulp" ; oboInOwl:hasExactSynonym "pulpa rubra", "red pulp", "spleen red pulp", "splenic red pulp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pulpa splenica" ; oboInOwl:id "UBERON:0001250" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "red pulp of spleen" ; rdfs:subClassOf obo:UBERON_1000023, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002106 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000542 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png"^^xsd:anyURI . obo:UBERON_0001251 obo:IAO_0000115 "The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens." ; obo:UBPROP_0000012 "WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line." ; oboInOwl:hasBroadSynonym "marginal zone" ; oboInOwl:hasDbXref "CALOHA:TS-2395", "EMAPA:36650", "FMA:15852", "MA:0000755", "NCIT:C49767", "UMLS:C1711368", "Wikipedia:Marginal_zone" ; oboInOwl:hasExactSynonym "junctional zone of spleen", "spleen marginal zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001251" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "marginal zone of spleen" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001250 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001959 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png"^^xsd:anyURI . obo:UBERON_0001252 obo:IAO_0000115 "An adventitia that is part of a ureter." ; oboInOwl:hasDbXref "EMAPA:28114", "FMA:15892", "MA:0002652", "SCTID:392273001", "SCTID:47879001" ; oboInOwl:hasExactSynonym "external adventitia of ureter", "tunica adventitia (ureter)", "tunica adventitia ureteris", "ureter adventitia", "ureteral adventitia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001252" ; a owl:Class ; rdfs:label "adventitia of ureter" ; rdfs:subClassOf _:genid115457 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0001253 obo:IAO_0000115 "A lamina propria that is part of a ureter [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:28841", "FMA:15896", "MA:0002653", "SCTID:2771005" ; oboInOwl:hasExactSynonym "lamina propria mucosa of ureter", "lamina propria mucosae of ureter", "ureter lamina propria", "ureter lamina propria mucosa", "ureter lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001253" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lamina propria of ureter" ; rdfs:subClassOf obo:UBERON_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ], _:genid115467, _:genid115469 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0001255 obo:IAO_0000115 "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." ; obo:UBPROP_0000001 "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]", "Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]" ; obo:UBPROP_0000003 "In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]" ; obo:UBPROP_0000007 "vesical" ; obo:UBPROP_0000008 "The urinary bladder evolved in tetrapods. Birds to not possess a true urinary bladder, although Palaeognathae have an undifferentiated cloacal outpocketing that serves a similar function[https://github.com/obophenotype/uberon/issues/454]" ; oboInOwl:hasBroadSynonym "bladder" ; oboInOwl:hasDbXref "AAO:0000623", "BTO:0001418", "CALOHA:TS-1090", "EFO:0000290", "EHDAA2:0000174", "EHDAA:9328", "EMAPA:18321", "EV:0100098", "FMA:15900", "GAID:0000004", "MA:0000380", "MAT:0000122", "MESH:D001743", "MIAA:0000122", "NCIT:C12414", "SCTID:302512001", "UMLS:C0005682", "VHOG:0000740", "Wikipedia:Urinary_bladder", "XAO:0000154", "galen:UrinaryBladder" ; oboInOwl:hasExactSynonym "vesica urinaria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urocyst", "vesica" ; oboInOwl:id "UBERON:0001255" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "urinary bladder" ; rdfs:subClassOf obo:UBERON_0018707, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ], _:genid115477, _:genid115480 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg"^^xsd:anyURI . obo:UBERON_0001256 obo:IAO_0000115 "An anatomical wall that lines the insider of a urinary bladder." ; oboInOwl:hasDbXref "BTO:0001462", "EMAPA:35175", "FMA:15902", "MA:0002493", "NCIT:C48941", "SCTID:362225003", "UMLS:C0458421" ; oboInOwl:hasExactSynonym "anatomical wall of bladder", "anatomical wall of urinary bladder", "bladder anatomical wall", "bladder wall", "urinary bladder anatomical wall", "urinary bladder wall", "wall of bladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001256" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "wall of urinary bladder" ; rdfs:subClassOf obo:UBERON_0000060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0001258 obo:IAO_0000115 "The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP]." ; oboInOwl:hasDbXref "EMAPA:36078", "FMA:15912", "MA:0002491", "NCIT:C12336", "SCTID:362227006", "UMLS:C0227716", "Wikipedia:Neck_of_urinary_bladder", "galen:UrinaryBladderNeck" ; oboInOwl:hasExactSynonym "bladder neck", "cervix vesicae", "collum vesicae", "neck of bladder", "urinary bladder neck", "vesical neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervix vesicae urinariae" ; oboInOwl:id "UBERON:0001258" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "neck of urinary bladder" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png"^^xsd:anyURI . obo:UBERON_0001259 obo:IAO_0000115 "The mucous membrane lining the urinary bladder." ; oboInOwl:hasDbXref "EFO:0000293", "EMAPA:35897", "FMA:15928", "MA:0001692", "NCIT:C32205", "SCTID:362224004", "UMLS:C0227691", "galen:MucousMembraneOfUrinaryBladder" ; oboInOwl:hasExactSynonym "bladder mucosa", "bladder mucous membrane", "bladder organ mucosa", "mucosa of bladder", "mucous membrane of bladder", "mucous membrane of urinary bladder", "tunica mucosa (vesica urinaria)", "tunica mucosa vesicae", "tunica mucosa vesicae urinariae", "urinary bladder mucosa", "urinary bladder mucous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001259" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mucosa of urinary bladder" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0001260 obo:IAO_0000115 "A serous membrane that is part of a urinary bladder [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check serosa/peritoneum" ; oboInOwl:hasDbXref "EMAPA:28661", "FMA:15932", "MA:0001696", "SCTID:5868002" ; oboInOwl:hasExactSynonym "bladder serosa", "bladder serous membrane", "serosa of bladder", "serous coat of bladder", "serous coat of urinary bladder", "serous membrane of bladder", "serous membrane of urinary bladder", "tunica serosa (vesica urinaria)", "tunica serosa vesicae", "urinary bladder serosa", "urinary bladder serous membrane", "visceral peritoneum of urinary bladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001260" ; a owl:Class ; rdfs:label "serosa of urinary bladder" ; rdfs:subClassOf obo:UBERON_0000042, _:genid115533 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid115292 ] . obo:UBERON_0001261 obo:IAO_0000115 "A lamina propria that is part of a urinary bladder [Automatically generated definition]." ; obo:UBPROP_0000010 "Contains loose to dense connective tissue, variably sized blood vessels that may be close to epithelium, lymphatics, variable adipose tissue" ; oboInOwl:hasDbXref "EMAPA:30088", "FMA:15935", "MA:0001695", "NCIT:C48940", "UMLS:C1706967" ; oboInOwl:hasExactSynonym "bladder lamina propria", "bladder lamina propria mucosa", "bladder lamina propria mucosae", "lamina propria mucosa of bladder", "lamina propria mucosa of urinary bladder", "lamina propria mucosae of bladder", "lamina propria mucosae of urinary bladder", "lamina propria of bladder", "urinary bladder lamina propria", "urinary bladder lamina propria mucosa", "urinary bladder lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001261" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lamina propria of urinary bladder" ; rdfs:subClassOf obo:UBERON_0000030, _:genid115307, _:genid115546 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0001262 obo:IAO_0000115 "An anatomical wall that is part of a intestine [Automatically generated definition]." ; obo:IAO_0000116 "we place two MA classes here due to the official ncit2ma mapping to intestinal wall tissue; not clear how bowel and intestine are different" ; oboInOwl:hasDbXref "BTO:0000647", "EMAPA:35444", "FMA:15949", "MA:0001525", "MA:0002693", "NCIT:C49478", "UMLS:C1708548" ; oboInOwl:hasExactSynonym "anatomical wall of bowel", "anatomical wall of intestine", "bowel anatomical wall", "bowel wall", "intestinal wall", "intestine anatomical wall", "intestine wall", "wall of bowel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bowel wall" ; oboInOwl:id "UBERON:0001262" ; a owl:Class ; rdfs:label "wall of intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0001263 obo:IAO_0000115 "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." ; oboInOwl:hasDbXref "EMAPA:35651", "FMA:16011", "MA:0002417", "NCIT:C49268", "SCTID:247604006", "UMLS:C0227578" ; oboInOwl:hasExactSynonym "acinus pancreaticus", "pancreas acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreatic acinar", "pancreatic acini" ; oboInOwl:id "UBERON:0001263" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "pancreatic acinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002064 ], _:genid115578 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:UBERON_0001264 obo:IAO_0000115 "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." ; obo:UBPROP_0000001 "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" ; obo:UBPROP_0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" ; obo:UBPROP_0000007 "pancreatic" ; obo:UBPROP_0000008 "As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)", "The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm" ; obo:UBPROP_0000009 "The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans" ; oboInOwl:hasDbXref "AAO:0010112", "BTO:0000988", "CALOHA:TS-0736", "EFO:0000855", "EHDAA2:0001367", "EHDAA:6893", "EMAPA:17503", "EV:0100092", "FMA:7198", "GAID:334", "MA:0000120", "MAT:0000075", "MESH:D010179", "MIAA:0000075", "NCIT:C12393", "SCTID:181277001", "TAO:0000140", "UMLS:C0030274", "VHOG:0000050", "Wikipedia:Pancreas", "XAO:0000136", "ZFA:0000140", "galen:Pancreas" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001264" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pancreas" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003922 ], _:genid115589, _:genid115591 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png"^^xsd:anyURI . obo:UBERON_0001265 obo:IAO_0000115 "A trabecula that is part of a spleen." ; oboInOwl:hasDbXref "EMAPA:35808", "FMA:16027", "MA:0000758", "NCIT:C33607", "SCTID:61987002", "UMLS:C0229688", "Wikipedia:Trabeculae_of_spleen" ; oboInOwl:hasExactSynonym "spleen trabeculum", "splenic trabecula", "trabeculae of spleen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001265" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "trabecula of spleen" ; rdfs:subClassOf _:genid115603 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0001267 obo:IAO_0000115 "The femoral nerve, the largest branch of the lumbar plexus, arises from the ventral divisions of the second, third, and fourth lumbar nerves. It descends through the fibers of the Psoas major, emerging from the muscle at the lower part of its lateral border, and passes down between it and the Iliacus, behind the iliac fascia; it then runs beneath the inguinal ligament, into the thigh, and splits into an anterior and a posterior division. Under the inguinal ligament, it is separated from the femoral artery by a portion of the Psoas major. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0000507", "EHDAA:5655", "EMAPA:35343", "FMA:16486", "GAID:850", "MA:0001167", "MESH:D005267", "NCIT:C52816", "SCTID:181051004", "UMLS:C0015808", "VHOG:0001411", "Wikipedia:Femoral_nerve" ; oboInOwl:hasExactSynonym "anterior crural nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus femoralis" ; oboInOwl:id "UBERON:0001267" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "femoral nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004482 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray823.png"^^xsd:anyURI . obo:UBERON_0001268 obo:IAO_0000115 "Transudate contained in the peritoneal cavity." ; oboInOwl:hasDbXref "BTO:0001031", "EMAPA:35683", "FMA:16515", "MA:0002531", "Wikipedia:Peritoneal_fluid", "ncithesaurus:Peritoneal_Fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001268" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "peritoneal fluid" ; rdfs:subClassOf obo:UBERON_0007794 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007779 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ] ) ] . obo:UBERON_0001269 obo:IAO_0000115 "The acetabulum is a concave surface of the pelvis. The head of the femur meets with the pelvis at the acetabulum, forming the hip joint. There are three bones of the os coxae (hip bone) that come together to form the acetabulum. Contributing a little more than two-fifths of the structure is the ischium, which provides lower and side boundaries to the acetabulum. The ilium forms the upper boundary, providing a little less than two-fifths of the structure of the acetabulum. The rest is formed by the pubis, near the midline. It is bounded by a prominent uneven rim, which is thick and strong above, and serves for the attachment of the acetabular labrum, which reduces its opening, and deepens the surface for formation of the hip joint. At the lower part of the acetabulum is the acetabular notch, which is continuous with a circular depression, the acetabular fossa, at the bottom of the cavity of the acetabulum. The rest of the acetabulum is formed by a curved, crescent-moon shaped surface, the lunate surface, where the joint is made with the head of the femur. Its counterpart in the pectoral girdle is the glenoid fossa.[WP,unvetted]." ; obo:UBPROP_0000001 "Cavity for the articulation of the proximal bone of the hind limb.[AAO]" ; obo:UBPROP_0000003 "During the transformation from the osteolepiform fins to tetrapod limbs, the appendages and girdles underwent a number of radical changes. The pelvic girdle became a weight-bearing structure by evolution of an ischium, a full mesio-ventral contact between the two sides of the girdle, an ilium, and a contact between the vertebral column and the girdle through a sacral rib. Fore- and hindlimbs shifted laterally by reorientation of the glenoid and the acetabulum.[well established][VHOG]" ; obo:UBPROP_0000008 "In reptiles and in birds, the acetabula are deep sockets." ; obo:UBPROP_0000012 "whilst WP defines this as a surface, MA treats it as a bone. There are other FMA classes that may be better suited to representing the surface." ; oboInOwl:hasDbXref "AAO:0000770", "EHDAA:10661", "EMAPA:18346", "FMA:16579", "GAID:206", "MA:0001335", "MESH:D000077", "NCIT:C32042", "RETIRED_EHDAA2:0001427", "SCTID:182027007", "UMLS:C0000962", "VHOG:0000974", "Wikipedia:Acetabulum" ; oboInOwl:hasExactSynonym "acetabular region", "acetabulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001269" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "acetabular part of hip bone" ; rdfs:subClassOf obo:UBERON_0005913, _:genid115620, _:genid115622 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg"^^xsd:anyURI . obo:UBERON_0001270 obo:IAO_0000115 "A ring of bone formed by the sacrum and the first few coccygeal vertebrae as the roof, the pubis and ischia as the floor and the ilia and the acetabular part of the ischia as the walls." ; obo:IAO_0000116 "TODO add taxon-specific part of relations connecting sub-structures to this." ; obo:UBPROP_0000012 "in FMA, this is part of the axial skeletal system" ; oboInOwl:hasDbXref "FMA:16580", "SCTID:46633002" ; oboInOwl:hasExactSynonym "pelvis ossea", "skeletal system of pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001270" ; a owl:Class ; rdfs:label "bony pelvis" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001274 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001275 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003690 ] ; owl:disjointWith obo:UBERON_0002355 . obo:UBERON_0001271 obo:IAO_0000115 "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions." ; obo:IAO_0000232 "this class describes the subdivision of the limb/fin, NOT the skeleton within. See also: skeleton of pectoral girdle (UBERON:0007831). See also comments on obo-anatomy mail list. Note that even though the class includes soft tissue it is more restrictive than 'pelvis' which also includes structures in cavities etc. TODO this needs to be better documented" ; obo:UBPROP_0000001 "Subdivision of lower limb or fin which links the limb/fin to the body[FMA,modified]. There is only one instance of the pelvic girdle region per organism.[VSAO]" ; oboInOwl:hasDbXref "EMAPA:37862", "FMA:16581", "NCIT:C33291", "SCTID:360010001", "UMLS:C0684083", "VSAO:0000304" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "girdle - pelvic", "pelvic girdle" ; oboInOwl:id "UBERON:0001271" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pelvic girdle region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0007832 ] ; owl:disjointWith obo:UBERON_0007832 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid115394 ] . obo:UBERON_0001272 obo:IAO_0000115 "A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]." ; obo:IAO_0000116 "currently this class is restricted to exclude the teleost bone as the definition mentions ilium, ischium and pubis. In future we may add a grouping class for girdle bones that supports the appendage" ; obo:UBPROP_0000008 "The hip/pelvic bone/basipterygium first appears in fishes, where it consists of a simple, usually triangular bone, to which the pelvic fin articulates. The hip bones on each side usually connect with each other at the forward end, and are even solidly fused in lungfishes and sharks, but they never attach to the vertebral column" ; obo:UBPROP_0000012 "in FMA this is a paired structure. NCITA has 'pelvic bone' but this is the *superclass* of ilium/ischium/pubis. The MA class 'pelvis bone' is actually a superclass of 'pelvic girdle bone' and caudal/sacral vertebra." ; oboInOwl:hasBroadSynonym "bone of pelvic girdle", "innominate" ; oboInOwl:hasDbXref "FMA:16585", "GAID:205", "SCTID:361776002", "Wikipedia:Hip_bone" ; oboInOwl:hasExactSynonym "coxal bone", "hip bone", "innominate bone", "os coxa", "os coxae", "pelvic bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basipterygium", "os innominatum" ; oboInOwl:id "UBERON:0001272" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "innominate bone" ; rdfs:subClassOf obo:UBERON_0010428, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0007832 ], _:genid115652 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png"^^xsd:anyURI . obo:UBERON_0001273 obo:IAO_0000115 "Paired endochondral bone that is the dorsal-most of the pelvic bones, offering attachment areas for gluteal muscles on its main surface [PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "Paired, rodlike endochondral bones that constitute the anterior pelvic girdle.[AAO]" ; obo:UBPROP_0000007 "iliac" ; obo:UBPROP_0000008 "All reptiles have an ilium except snakes, although some snake species have a tiny bone which is considered to be an ilium" ; obo:UBPROP_0000012 "this is_a hip bone in MA." ; oboInOwl:hasDbXref "AAO:0000772", "CALOHA:TS-2200", "EFO:0003049", "EMAPA:18726", "FMA:16589", "GAID:207", "MA:0001336", "MESH:D007085", "NCIT:C32765", "SCTID:182029005", "UMLS:C0020889", "Wikipedia:Ilium_(bone)", "galen:Ilium" ; oboInOwl:hasExactSynonym "iliac bone", "ilium bone", "os iliacum", "os ilii", "os ilium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "illium" ; oboInOwl:id "UBERON:0001273" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ilium" ; rdfs:subClassOf _:genid115424, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0007830 ], _:genid115671, _:genid115673, _:genid115676 ; owl:equivalentClass _:genid115420 . obo:UBERON_0001274 obo:IAO_0000115 "Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium." ; obo:UBPROP_0000001 "Paired bones of endochondral origin that constitute the posterior elements of the pelvic girdle. They are synostotically fused to each other and form the posterior part of the acetabulum.[AAO]" ; obo:UBPROP_0000007 "ischial" ; obo:UBPROP_0000012 "this is_a hip bone in MA; in FMA it is a zone of bone organ." ; oboInOwl:hasDbXref "AAO:0000860", "EMAPA:18727", "FMA:16592", "GAID:208", "MA:0001337", "MESH:D007512", "NCIT:C32884", "SCTID:182025004", "UMLS:C0022122", "VSAO:0005006", "Wikipedia:Ischium", "galen:Ischium" ; oboInOwl:hasExactSynonym "ischial bone", "ischium bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os ischii" ; oboInOwl:id "UBERON:0001274" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ischium" ; rdfs:subClassOf obo:UBERON_0002513, obo:UBERON_0007830, obo:UBERON_0008202, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001272 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0007832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0007830 ], _:genid115694, _:genid115697 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015056 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg"^^xsd:anyURI . obo:UBERON_0001275 obo:IAO_0000115 "A paired endochondral bone making up the anteroventral region of the tripartite pelvic girdle forming part of the ventral edge of the acetabulum. The origin site of many proximal hindlimb muscles. [PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "Paired, cartilaginous (ocassionally calcified) elements that form the ventral portion of the pelvic girdle. Each is located ventral to the acetabulum between the anteroventral margin of the ischium and the posteroventral margin of the illium. When the element calcifies or ossifies, its articulation with adjacent elements is difficult to distinguish. Both pubes are synchondrotically fused to one another.[AAO]" ; obo:UBPROP_0000012 "isa bone zone in FMA" ; oboInOwl:hasDbXref "AAO:0000861", "EMAPA:18728", "FMA:16595", "MA:0001338", "MESH:D011630", "NCIT:C33423", "SCTID:182035005", "UMLS:C0034014", "Wikipedia:Pubis_(bone)", "galen:Pubis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os pubis", "pubic bone", "pubis bone" ; oboInOwl:id "UBERON:0001275" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pubis" ; rdfs:subClassOf obo:UBERON_0002513, obo:UBERON_0007830, obo:UBERON_0008202, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0007832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010718 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0007830 ], _:genid115713, _:genid115715 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015055 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001276 obo:IAO_0000115 "The epithelial layer of the stomach ." ; obo:UBPROP_0000012 "in FMA this is classified as simple columnar, MA divides this into squamous and glandular" ; oboInOwl:hasDbXref "BTO:0000500", "CALOHA:TS-2068", "EHDAA2:0001918", "EMAPA:17023", "FMA:17091", "MA:0001610", "SCTID:64977002", "VHOG:0001433" ; oboInOwl:hasExactSynonym "epithelial tissue of stomach", "epithelial tissue of ventriculus", "epithelium of ventriculus", "stomach epithelial tissue", "stomach epithelium", "ventriculus epithelial tissue", "ventriculus epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric epithelium" ; oboInOwl:id "UBERON:0001276" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of stomach" ; rdfs:subClassOf obo:UBERON_0000485, _:genid115477, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0001277 obo:IAO_0000115 "Epithelial layer that lines the intestine." ; obo:UBPROP_0000001 "Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO]" ; oboInOwl:hasDbXref "BTO:0000781", "EMAPA:32873", "FMA:17229", "MA:0001536", "NCIT:C49240", "SCTID:266135004", "TAO:0005124", "UMLS:C0226890", "Wikipedia:Intestinal_epithelium", "ZFA:0005124" ; oboInOwl:hasExactSynonym "bowel epithelial tissue", "bowel epithelium", "epithelial tissue of bowel", "epithelial tissue of intestine", "epithelium of bowel", "epithelium of intestine", "intestine epithelial tissue" ; oboInOwl:hasNarrowSynonym "villous epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestine epithelium" ; oboInOwl:id "UBERON:0001277" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intestinal epithelium" ; rdfs:subClassOf obo:UBERON_0000485, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001242 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000160 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0001278 obo:IAO_0000115 "An epithelium that is part of a large intestine [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-2105", "EMAPA:35466", "FMA:17301", "MA:0001545" ; oboInOwl:hasExactSynonym "epithelial tissue of large intestine", "large intestinal epithelium", "large intestine epithelial tissue", "large intestine epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001278" ; a owl:Class ; rdfs:label "epithelium of large intestine" ; rdfs:subClassOf obo:UBERON_0001277, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001207 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0001279 obo:IAO_0000115 "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." ; obo:UBPROP_0000013 "The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver." ; oboInOwl:hasDbXref "FMA:17523", "MA:0002499", "NCIT:C33342", "SCTID:362192000", "UMLS:C0227514", "Wikipedia:Portal_triad" ; oboInOwl:hasExactSynonym "trias hepatica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trias hepatica" ; oboInOwl:id "UBERON:0001279" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "portal triad" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001172 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001193 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002017 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003704 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001171 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG"^^xsd:anyURI . obo:UBERON_0001280 obo:IAO_0000115 "The functional units of the liver including the lobules." ; obo:UBPROP_0000003 "the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0003223" ; oboInOwl:hasDbXref "AAO:0010405", "EHDAA2:0001004", "EHDAA:2201", "EMAPA:17203", "FMA:17540", "MA:0000366", "NCIT:C32735", "SCTID:363535004", "UMLS:C0736268", "VHOG:0000539", "XAO:0000454" ; oboInOwl:hasExactSynonym "hepatic parenchyma", "liver parenchyme", "parenchyma of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic parenchyme" ; oboInOwl:id "UBERON:0001280" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "liver parenchyma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002107 ], _:genid115780 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0001281 obo:IAO_0000115 "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." ; obo:UBPROP_0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0003275" ; oboInOwl:hasDbXref "EHDAA2:0000999", "EMAPA:17365", "FMA:17543", "MA:0000367", "NCIT:C32733", "SCTID:67435004", "TAO:0005091", "UMLS:C0227523", "VHOG:0000708", "Wikipedia:Hepatic_sinusoid", "ZFA:0005091" ; oboInOwl:hasExactSynonym "liver hepatic sinusoids", "liver sinusoid", "liver sinusoidal blood vessel", "sinusoid of liver", "sinusoidal blood vessel of liver", "vas capillare sinusoideum", "vas sinusoideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic sinusoids" ; oboInOwl:id "UBERON:0001281" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatic sinusoid" ; rdfs:subClassOf obo:UBERON_0003909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004647 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0006841 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002226 ; owl:someValuesFrom obo:UBERON_0001113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004647 ], _:genid115794 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0001282 obo:IAO_0000115 "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." ; obo:IAO_0000116 "Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct)" ; oboInOwl:hasDbXref "FMA:17545", "MA:0002669", "NCIT:C32255", "SCTID:227002", "SCTID:269922006", "UMLS:C0227517", "Wikipedia:Canals_of_Hering" ; oboInOwl:hasExactSynonym "canal of Herring", "cholangiole", "ductus interlobularis bilifer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canal of Hering", "canals of Hering", "duct of Herring", "intrahepatic bile ductule" ; oboInOwl:id "UBERON:0001282" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "intralobular bile duct" ; rdfs:subClassOf obo:UBERON_0003704, obo:UBERON_0014716, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000182 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000488 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004647 ], _:genid115808, _:genid115810 . obo:UBERON_0001285 obo:IAO_0000115 "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]." ; obo:IAO_0000116 "kidney terms require review for cross-vertebrate compatibility and developmental relationships." ; obo:UBPROP_0000001 "Functional unit of the kidney that filters waste.[TAO]" ; obo:UBPROP_0000008 "In the avian kidney, three types of nephron are identified: mammalian-type nephrons with long and short loops of Henle, and reptilian type nephrons (Gambaryan, 1992)" ; oboInOwl:hasDbXref "BTO:0000924", "CALOHA:TS-1312", "EMAPA:28491", "EMAPA:35592", "EV:0100384", "FMA:17640", "GAID:428", "MA:0000375", "MESH:D009399", "NCIT:C13048", "SCTID:361337001", "TAO:0002153", "UMLS:C0027713", "Wikipedia:Nephron", "ZFA:0005282" ; oboInOwl:hasNarrowSynonym "mature nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nephroneum", "tubulus renalis" ; oboInOwl:id "UBERON:0001285" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nephron" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid115823, _:genid115825, _:genid115828 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png"^^xsd:anyURI . obo:UBERON_0001294 obo:IAO_0000115 "Innermost region of the mammalian kidney." ; obo:UBPROP_0000008 "unique to mammals" ; oboInOwl:hasDbXref "BTO:0001745", "CALOHA:TS-0506", "EMAPA:28349", "FMA:17734", "MA:0001652" ; oboInOwl:hasExactSynonym "inner renal medulla", "inner zone of medulla of kidney", "inner zone of renal medulla", "renal inner medulla", "set of inner region of renal pyramids", "zona interna (medullaris renalis)", "zona interna medullae renalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney inner medulla" ; oboInOwl:id "UBERON:0001294" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "inner medulla of kidney" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid115578 . obo:UBERON_0001295 obo:IAO_0000115 "The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy." ; obo:UBPROP_0000001 "The mucous membrane lining the uterus. [TFD][VHOG]" ; obo:UBPROP_0000003 "The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG]" ; obo:UBPROP_0000007 "endometrial" ; obo:UBPROP_0000008 "Animals that have estrous cycles reabsorb the endometrium if conception does not occur during that cycle. Animals that have menstrual cycles shed the endometrium through menstruation instead" ; obo:UBPROP_0000012 "in FMA this is subdivided into basal and outer" ; oboInOwl:hasDbXref "BTO:0001422", "CALOHA:TS-0276", "EFO:0000980", "EMAPA:29917", "EV:0100115", "FMA:17742", "GAID:377", "MA:0000390", "MAT:0000319", "MESH:D004717", "MIAA:0000319", "NCIT:C12313", "SCTID:278867007", "UMLS:C0014180", "VHOG:0001285", "Wikipedia:Endometrium" ; oboInOwl:hasExactSynonym "tunica mucosa (endometrium)", "tunica mucosa uteri", "uterine endometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "uterine mucosa", "uterine mucous membrane" ; oboInOwl:id "UBERON:0001295" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "endometrium" ; rdfs:subClassOf _:genid115589, _:genid115850 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg"^^xsd:anyURI . obo:UBERON_0001297 obo:IAO_0000115 "Outer serosa layer of the uterus." ; obo:IAO_0000116 "TODO - check for parallel structure with peritoneum" ; oboInOwl:hasDbXref "EMAPA:37792", "FMA:17744", "MA:0001729", "NCIT:C33298", "SCTID:253705006", "UMLS:C0227824", "Wikipedia:Perimetrium" ; oboInOwl:hasExactSynonym "perimetrium", "serous coat of uterus", "serous membrane of uterus", "tunica serosa (perimetrium)", "tunica serosa uteri", "uterine serosa", "uterus serosa", "uterus serous membrane", "visceral peritoneum of uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001297" ; a owl:Class ; rdfs:label "serosa of uterus" ; rdfs:subClassOf _:genid115866 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg"^^xsd:anyURI . obo:UBERON_0001299 obo:IAO_0000115 "The conic expansion of the corpus spongiosum that forms the head of the penis." ; oboInOwl:hasBroadSynonym "glans" ; oboInOwl:hasDbXref "BTO:0003118", "EMAPA:18988", "EV:0100108", "FMA:18247", "GAID:0000012", "MA:0002726", "NCIT:C12324", "SCTID:263378009", "UMLS:C0227948", "VHOG:0001475", "Wikipedia:Glans_penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "balanus", "coronal sulcus" ; oboInOwl:id "UBERON:0001299" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "glans penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000989 ], [ a owl:Restriction ; owl:onProperty core:sexually_homologous_to ; owl:someValuesFrom obo:UBERON_0006653 ], _:genid115881 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035651 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png"^^xsd:anyURI . obo:UBERON_0001300 obo:IAO_0000115 "The external sac of skin that encloses the testes. It is an extension of the abdomen, and in placentals is located between the penis and anus." ; obo:UBPROP_0000007 "scrotal" ; obo:UBPROP_0000008 "In elephants the testes remain in the abdomen", "In hedgehogs the testes remain in the inguinal canal", "In humans and some other mammals, the base of the scrotum becomes covered with pubic hair at puberty", "In marsupials, the scrotum is not homologous to the eutherian scrotum, and development is under the control of X-linked genes, not androgens", "In marsupials, the scrotum is positioned in the caudal area of the abdomen, in the same position as the pouch in females. It has been suggested that the pouch and marsupial scrotum are sexual homologs, but it is more likely they arise from different primordia in the same morphogenetic field", "The scrotum of marsupials is not homologous with the scrotum of mammals[ISBN:113945742X]" ; oboInOwl:hasDbXref "BTO:0003098", "CALOHA:TS-2341", "EMAPA:19296", "FMA:18252", "GAID:393", "MA:0000409", "MESH:D012611", "NCIT:C12785", "SCTID:265794003", "UMLS:C0036471", "Wikipedia:Scrotum", "galen:Scrotum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001300" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "scrotum" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004053 ], _:genid115890 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Scrotum_warm_and_cold.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/3/3e/HairedHumanScrotum.png/200px-HairedHumanScrotum.png"^^xsd:anyURI . obo:UBERON_0001301 obo:IAO_0000115 "The elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens." ; obo:IAO_0000116 "Kardong has epididymis in elasmobranch" ; obo:UBPROP_0000007 "epididymal" ; obo:UBPROP_0000008 "A similar, but probably non-homologous, structure is found in cartilaginous fishes" ; obo:UBPROP_0000010 "Typically divided into three main regions. In reptiles, there is an additional canal between the testis and the head of the epididymis, which receives the various efferent ducts. This is, however, absent in all birds and mammals. The epididymis is covered by a two layered pseudostratified epithelium. The epithelium is separated by a basement membrane from the connective tissue wall which has smooth muscle cells." ; oboInOwl:hasDbXref "BTO:0000408", "CALOHA:TS-0285", "EFO:0000982", "EMAPA:19290", "EV:0100103", "FMA:18255", "GAID:397", "MA:0000397", "MAT:0000130", "MESH:D004822", "MIAA:0000130", "NCIT:C12328", "SCTID:181432000", "UMLS:C0014533", "VHOG:0001265", "Wikipedia:Epididymis", "galen:Epididymis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001301" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "epididymis" ; rdfs:subClassOf obo:UBERON_0000058, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004054 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:CL_0000019 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0006946 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001000 ], _:genid115899, _:genid115901 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_testis_surface.jpg"^^xsd:anyURI . obo:UBERON_0001302 obo:IAO_0000115 "A fallopian tube that is part of a right side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "non-functional in monotremes[ISBN:978-0226870137]" ; oboInOwl:hasDbXref "EMAPA:37369", "FMA:18483", "MA:0001717", "NCIT:C33475", "SCTID:280106006", "UMLS:C0227900" ; oboInOwl:hasExactSynonym "right fallopian tube", "right oviduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001302" ; a owl:Class ; rdfs:label "right uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003889 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0001303 obo:IAO_0000115 "A fallopian tube that is part of a left side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37368", "FMA:18484", "MA:0001716", "NCIT:C32959", "SCTID:280107002", "UMLS:C0227902" ; oboInOwl:hasExactSynonym "left fallopian tube", "left oviduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001303" ; a owl:Class ; rdfs:label "left uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003889 _:genid115652 ) ] . obo:UBERON_0001304 obo:IAO_0000115 "Layer of simple cuboidal cells covering surface of ovary[WP]." ; oboInOwl:hasDbXref "BTO:0004483", "EHDAA:8126", "EMAPA:17963", "FMA:18629", "MA:0001711", "NCIT:C61518", "RETIRED_EHDAA2:0001361", "SCTID:258308007", "UMLS:C0227875", "VHOG:0000630", "Wikipedia:Germinal_epithelium_(female)" ; oboInOwl:hasExactSynonym "epithelium superficiale (ovarium)", "germinal epithelium (female)", "ovarian surface epithelium", "ovary germinal epithelium", "surface epithelium of ovary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "female coelomic epithelium", "ovary surface epithelium" ; oboInOwl:id "UBERON:0001304" ; a owl:Class ; rdfs:comment "Controversial - see article. Requires expert input. Also check BTO placement" ; rdfs:label "germinal epithelium of ovary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000484 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001307 ] ) ] . obo:UBERON_0001307 obo:IAO_0000115 "A capsule that surrounds a female gonad." ; oboInOwl:hasDbXref "EMAPA:35626", "FMA:18662", "MA:0001706", "NCIT:C49265", "SCTID:258491008", "UMLS:C0227877" ; oboInOwl:hasExactSynonym "ovarian capsule", "ovary capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001307" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "capsule of ovary" ; rdfs:subClassOf obo:UBERON_0003893 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0001308 obo:IAO_0000115 "The external iliac artery is a large artery in the pelvic region that carries blood to the lower limb. The external iliac artery is a paired artery, meaning there is one on each side of the body: a right external iliac artery and left external iliac artery. The external iliac artery is accompanied by the external iliac vein, which is located posterior to the artery. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0004666", "EHDAA2:0000463", "EHDAA:4337", "EMAPA:17614", "FMA:18805", "MA:0001973", "NCIT:C32558", "SCTID:181352000", "UMLS:C0226398", "Wikipedia:External_iliac_artery", "galen:ExternalIliacArtery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria iliaca externa" ; oboInOwl:id "UBERON:0001308" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "external iliac artery" ; rdfs:subClassOf obo:UBERON_0005609, _:genid115673 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray539.png"^^xsd:anyURI . obo:UBERON_0001309 obo:IAO_0000115 "The internal iliac artery (formerly known as the hypogastric artery) is the main artery of the pelvis. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0004667", "EMAPA:17860", "FMA:18808", "MA:0001974", "NCIT:C32845", "SCTID:181346001", "UMLS:C0226364", "Wikipedia:Internal_iliac_artery", "galen:InternalIliacArtery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria iliaca interna", "hypogastric artery" ; oboInOwl:id "UBERON:0001309" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "internal iliac artery" ; rdfs:subClassOf obo:UBERON_0005609, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001191 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d3/Iliac_artery_bifurcation.PNG"^^xsd:anyURI . obo:UBERON_0001310 obo:IAO_0000115 "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." ; obo:IAO_0000116 "todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships" ; oboInOwl:hasDbXref "BTO:0000841", "CALOHA:TS-1077", "EHDAA:1026", "EHDAA:410", "EMAPA:16331", "EMAPA:16372", "FMA:18820", "GAID:516", "MA:0002072", "MESH:D014469", "NCIT:C33827", "RETIRED_EHDAA2:0002106", "SCTID:261404000", "UMLS:C0041632", "Wikipedia:Umbilical_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "a. umbilicalis" ; oboInOwl:id "UBERON:0001310" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "umbilical artery" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/328"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0001637, _:genid115951 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png"^^xsd:anyURI . obo:UBERON_0001312 obo:IAO_0000115 "An artery that supplies blood to the upper urinary bladder." ; obo:UBPROP_0000011 "The first part of the superior vesical artery represents the terminal section of the previous portion of the umbilical artery (fetal hypogastric artery)[WP]" ; oboInOwl:hasDbXref "EMAPA:37123", "FMA:18839", "MA:0002080", "NCIT:C52686", "SCTID:113268007", "UMLS:C0226376", "Wikipedia:Superior_vesical_artery" ; oboInOwl:hasExactSynonym "arteria vesicali superior", "arteria vesicalis superior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriae vesicales superiores" ; oboInOwl:id "UBERON:0001312" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "superior vesical artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009027 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/02/Internal_iliac_branches.PNG"^^xsd:anyURI . obo:UBERON_0001316 obo:IAO_0000115 "A large vein that connects the femoral vein to the common iliac vein. Their origin is at the inferior margin of the inguinal ligaments and they terminate when they join the internal iliac veins (to form the common iliac veins). Both external iliac veins are accompanied along their course by external iliac arteries. [WP,modified]." ; oboInOwl:hasDbXref "EHDAA2:0000464", "EMAPA:37144", "FMA:18883", "MA:0002144", "NCIT:C32560", "SCTID:181400000", "UMLS:C0226761", "Wikipedia:External_iliac_vein", "galen:ExternalIliacVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena iliaca externa" ; oboInOwl:id "UBERON:0001316" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "external iliac vein" ; rdfs:subClassOf obo:UBERON_0005610, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001139 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002103 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif"^^xsd:anyURI . obo:UBERON_0001317 obo:IAO_0000115 "A vein that begins near the upper part of the greater sciatic foramen, passes upward behind and slightly medial to the hypogastric artery and, at the brim of the pelvis, joins with the external iliac to form the common iliac vein. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0000874", "EMAPA:37148", "FMA:18884", "MA:0002139", "MA:0002145", "NCIT:C32847", "SCTID:181399007", "UMLS:C0226764", "VHOG:0000749", "Wikipedia:Internal_iliac_vein", "galen:InternalIliacVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hypogastric vein", "v. hypogastrica", "v. iliaca interna" ; oboInOwl:id "UBERON:0001317" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "internal iliac vein" ; rdfs:subClassOf obo:UBERON_0005610, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001139 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0005179 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Internaliliacv.png"^^xsd:anyURI . obo:UBERON_0001319 obo:IAO_0000115 "One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified]." ; oboInOwl:hasDbXref "EMAPA:37796", "FMA:18899", "MA:0002251", "SCTID:424336009" ; oboInOwl:hasExactSynonym "vagina vein", "vein of vagina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001319" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "vaginal vein" ; rdfs:subClassOf obo:UBERON_0001638, _:genid115987 ; owl:equivalentClass _:genid115715 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png"^^xsd:anyURI . obo:UBERON_0001322 obo:IAO_0000115 "A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb." ; obo:UBPROP_0000008 "mouse sciatic nerve origins predominantly from the third lumbar (L3) and L4 spinal nerves, unlike the L4 and L5 in rats - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700063/" ; oboInOwl:hasDbXref "BIRNLEX:1133", "BTO:0001221", "CALOHA:TS-0899", "EFO:0001417", "EHDAA2:0001779", "EHDAA:5659", "EMAPA:18577", "FMA:19034", "GAID:852", "MA:0001172", "MESH:D012584", "NCIT:C52810", "SCTID:181050003", "UMLS:C0036394", "VHOG:0000894", "Wikipedia:Sciatic_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ischiadic nerve", "ischiatic nerve", "nervus ischiadicus", "nervus sciaticus" ; oboInOwl:id "UBERON:0001322" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sciatic nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001815 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000978 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001511 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png"^^xsd:anyURI . obo:UBERON_0001323 obo:IAO_0000115 "The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:36512", "FMA:19035", "GAID:854", "MA:0001173", "MESH:D013979", "NCIT:C52809", "SCTID:181078002", "UMLS:C0040186", "Wikipedia:Tibial_nerve" ; oboInOwl:hasExactSynonym "medial popliteal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "n. tibialis" ; oboInOwl:id "UBERON:0001323" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "tibial nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ], _:genid116003 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1a/Gray828.png"^^xsd:anyURI . obo:UBERON_0001325 obo:IAO_0000115 "Muscle (organ) which is a part of the pelvis. Examples: levator ani,." ; oboInOwl:hasDbXref "EMAPA:18184", "EMAPA:37481", "FMA:19086", "MA:0000534" ; oboInOwl:hasExactSynonym "muscle organ of pelvis", "pelvic muscle", "pelvis muscle", "pelvis muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001325" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "muscle of pelvis" ; rdfs:subClassOf obo:UBERON_0003833 ; owl:equivalentClass _:genid116008 . obo:UBERON_0001328 obo:IAO_0000115 "A portion of a prostate that forms a lobe." ; obo:UBPROP_0000008 "Anatomically, the human prostate gland is located between the base of the bladder and the rectum, and it completely surrounds the proximal urethra (Fig. 1A). It is a single alobular structure with central (CZ), peripheral (PZ) and transitional (TZ) zones. In contrast, the mouse prostate is not merged into one compact anatomical structure. It comprises four paired lobes situated circumferentially around the urethra, immediately caudal to the urinary bladder-namely, anterior (AP), dorsal (DP), lateral (LP), and ventral (VP) prostate (Fig. 1B). Often, the dorsal and the lateral lobes are thought of in combination and referred to as the dorsolateral (DLP) lobe as they share a ductal system. The mouse AP is considered analogous to the human CZ, which is rarely a site of neoplastic transformation in humans. The mouse DLP is considered most similar to the human PZ, which is the zone in which most carcinomas arise (Xue et al. 1997). These analogies, however, are limited as they are based solely on descriptive data and need to be re-evaluated using molecular techniques before the relationship between specific mouse prostate lobes and the human prostate zones is definitively asserted (Abate-Shen & Shen 2000). The mouse VP does not have a human homologue, and the human TZ does not have a murine homologue" ; oboInOwl:hasDbXref "BTO:0000548", "EMAPA:35712", "FMA:19570", "MA:0001738", "NCIT:C52726", "SCTID:279692004", "UMLS:C0227970" ; oboInOwl:hasExactSynonym "lobe of prostate gland", "prostate gland lobe", "prostatic lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001328" ; a owl:Class ; rdfs:label "lobe of prostate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0001330 obo:IAO_0000115 "The pampiniform plexus is a network of many small veins found in the male spermatic cord. It is formed by the union of multiple spermatic veins from the back of the testis and tributaries from the epididymis. The veins of the plexus ascend along the cord in front of the ductus deferens. Below the subcutaneous inguinal ring they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins. These again unite to form a single vein, the testicular vein, which opens on the right side into the inferior vena cava, at an acute angle, and on the left side into the left renal vein, at a right angle. The pampinoform plexus forms the chief mass of the cord. In addition to its function in venous return from the testes, the pampiniform plexus also plays a role in the temperature regulation of the testes. It acts as a heat exchanger, cooling blood in adjacent arteries. An abnormal enlargement of the pampiniform plexus is a medical condition called varicocele. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37385", "FMA:19607", "MA:0001866", "SCTID:279661001", "Wikipedia:Pampiniform_venous_plexus" ; oboInOwl:hasExactSynonym "pampiniform venous plexus", "plexus of veins of fascia of prostate", "plexus venosus pampiniformis", "venous plexus of fascia of prostate", "venous plexus of fascia of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001330" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "pampiniform plexus" ; rdfs:subClassOf obo:UBERON_0001593, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005352 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000442 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray1147.png"^^xsd:anyURI . obo:UBERON_0001331 obo:IAO_0000115 "A zone of skin that is part of a penis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35675", "FMA:19638", "MA:0002727", "SCTID:35900000" ; oboInOwl:hasExactSynonym "penile skin", "penis skin", "penis zone of skin", "zone of skin of penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001331" ; a owl:Class ; rdfs:label "skin of penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001085 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0001332 obo:IAO_0000115 "A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect." ; oboInOwl:hasBroadSynonym "prepuce", "preputium" ; oboInOwl:hasDbXref "BTO:0001113", "CALOHA:TS-0383", "EFO:0001664", "EMAPA:18989", "EV:0100109", "FMA:19639", "MA:0000407", "NCIT:C33049", "SCTID:181426005", "UMLS:C0227952", "Wikipedia:Foreskin" ; oboInOwl:hasExactSynonym "penile prepuce", "prepuce of male", "preputium penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foreskin", "praeputium", "prepucium" ; oboInOwl:id "UBERON:0001332" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "prepuce of penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001299 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0035005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011374 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg"^^xsd:anyURI . obo:UBERON_0001333 obo:IAO_0000115 "A urethra that is part of a male reproductive system." ; oboInOwl:hasDbXref "BTO:0004089", "EMAPA:18692", "FMA:19668", "MA:0002640", "NCIT:C33050", "SCTID:264085007", "UMLS:C0458452", "Wikipedia:Male_urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001333" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "male urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png"^^xsd:anyURI . obo:UBERON_0001334 obo:IAO_0000115 "A urethra that is part of a female reproductive system." ; oboInOwl:hasDbXref "BTO:0004088", "EMAPA:28747", "FMA:19669", "MA:0002637", "NCIT:C32591", "SCTID:264469008", "UMLS:C0458485", "Wikipedia:Female_urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethra feminina", "urethra muliebris" ; oboInOwl:id "UBERON:0001334" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "female urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000057 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png"^^xsd:anyURI . obo:UBERON_0001338 obo:IAO_0000115 "Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine." ; obo:UBPROP_0000012 "NCIT:C12339 paraurethral gland belongs here" ; oboInOwl:hasDbXref "EMAPA:37784", "FMA:19683", "MA:0001688", "SCTID:279477005" ; oboInOwl:hasExactSynonym "gland of urethra", "urethra gland", "urethra gland (male or female)", "urethral mucuous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001338" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "urethral gland" ; rdfs:subClassOf obo:UBERON_0000414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000057 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0001343 obo:IAO_0000115 "The tubules in the testes where spermatogenesis occurs." ; obo:UBPROP_0000001 "Any of the coiled tubules located in the testes in which spermatozoa are produced.[AAO]", "One of two or three twisted curved tubules in each lobule of the testis in which spermatogenesis occurs. [TFD][VHOG]" ; obo:UBPROP_0000003 "Frogs among amphibians and the amniotes have males with testes that are composed of seminiferous tubules, which differ from ampullae in being long, highly convoluted ductules.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010399", "BTO:0001235", "CALOHA:TS-1239", "EFO:0001404", "EMAPA:18685", "EMAPA:31476", "EV:0100380", "FMA:19825", "GAID:400", "MA:0000412", "MAT:0000503", "MESH:D012671", "NCIT:C13047", "NCIT:C34293", "SCTID:279614002", "UMLS:C0036630", "UMLS:C1519236", "VHOG:0001363", "Wikipedia:Seminiferous_tubule", "XAO:0003088" ; oboInOwl:hasExactSynonym "seminiferous cord", "seminiferous tubule", "testis - seminiferous tubule", "tubuli seminiferi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tubuli seminiferi" ; oboInOwl:id "UBERON:0001343" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "seminiferous tubule of testis" ; rdfs:subClassOf obo:UBERON_0000058, _:genid115810, [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0007283 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:CL_0000019 ], _:genid116083 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/Seminiferous_tubule_and_sperm_low_mag.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/6/6a/Gray1145.png"^^xsd:anyURI . obo:UBERON_0001344 obo:IAO_0000115 "The epithelial layer of the vagina." ; obo:UBPROP_0000012 "FMA: nonkeratinizing stratified squamous epithelium; BTO: Vaginal epithelium is stratified squamous epithelium having a thickness of 15-200 microns; MA has single subclass (squamous)" ; oboInOwl:hasDbXref "BTO:0000422", "CALOHA:TS-1325", "EMAPA:30991", "FMA:19978", "MA:0001730", "NCIT:C49313", "UMLS:C0920840" ; oboInOwl:hasExactSynonym "epithelial tissue of vagina", "vagina epithelial tissue", "vagina epithelium", "vaginal epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium, vaginal" ; oboInOwl:id "UBERON:0001344" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of vagina" ; rdfs:subClassOf obo:UBERON_0000486, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid115823 ] . obo:UBERON_0001350 obo:IAO_0000115 "A collection of caudal vertebrae in the coccygeal region that are fused and part of the bony pelvis." ; obo:UBPROP_0000001 "Small, bony element consisting of several fused, rudimentary caudal vertebrae; near metamorphosis the hypochord fuses to the coccyx, thereby forming the urostyle.[AAO]" ; obo:UBPROP_0000007 "coccygeal" ; obo:UBPROP_0000008 "In humans: The coccyx, commonly referred to as the tailbone, is the final segment of the human vertebral column. Comprising three to five separate or fused vertebrae (the coccygeal vertebrae) below the sacrum, it is attached to the sacrum by a fibrocartilaginous joint, the sacrococcygeal symphysis, which permits limited movement between the sacrum and the coccyx." ; oboInOwl:hasDbXref "AAO:0000731", "EHDAA2:0000259", "FMA:20229", "GAID:239", "MESH:D003050", "NCIT:C12696", "SCTID:182028002", "UMLS:C0009194", "Wikipedia:Coccyx", "galen:Coccyx" ; oboInOwl:hasExactSynonym "coccygeal skeleton", "coccygeal vertebrae I-IV", "coccyx [coccygeal vertebrae I-IV]", "coccyx [vertebrae coccygeae I-IV]", "fused caudal vertebrae", "fused caudal vertebral column", "os coccygis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os coccygis", "tailbone" ; oboInOwl:id "UBERON:0001350" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "coccyx" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007144 ], _:genid116113 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001270 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001095 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Gray100.png"^^xsd:anyURI . obo:UBERON_0001351 obo:IAO_0000115 "The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue." ; oboInOwl:hasDbXref "FMA:20289", "MA:0001298", "NCIT:C32909", "SCTID:362534009", "UMLS:C0229289", "Wikipedia:Lacrimal_sac" ; oboInOwl:hasExactSynonym "lachrymal sac", "lacrymal sac", "saccus lacrimalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001351" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lacrimal sac" ; rdfs:subClassOf obo:UBERON_0034944, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002392 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png"^^xsd:anyURI . obo:UBERON_0001352 obo:IAO_0000115 "A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter." ; obo:IAO_0000116 "consider revisiting superclass after refinement of CARO/EAO, conduit may not be quite correct." ; obo:UBPROP_0000011 "tympanic ring, which serves as support for the tympanic membrane, directs invagination of the first pharingeal cleft ectoderm to form the external acoustic meatus (EAM), which provides the outer layer of the membrane[PMID 11237469]" ; obo:UBPROP_0000012 "subdivision of head in FMA." ; oboInOwl:hasDbXref "EHDAA2:0000460", "EHDAA:8975", "EMAPA:17588", "EV:0100356", "FMA:61734", "GAID:864", "MA:0000260", "MESH:D004424", "NCIT:C12498", "SCTID:181178004", "UMLS:C0013444", "VHOG:0000977", "Wikipedia:External_acoustic_meatus", "galen:ExternalAuditoryMeatus" ; oboInOwl:hasExactSynonym "auditory canal", "ear canal", "external acoustic tube", "external auditory canal", "external auditory tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory meatus", "external auditory meatus" ; oboInOwl:id "UBERON:0001352" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "external acoustic meatus" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0055127 ], _:genid116133, _:genid116135, _:genid116138 . obo:UBERON_0001353 obo:IAO_0000115 "The anus and surrounding regions. Encompasses both internal and external regions, where present." ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EFO:0000847", "EHDAA2:0000122", "EHDAA:2931", "EMAPA:16831", "MA:0000329", "MAT:0000042", "MIAA:0000042", "NCIT:C32069", "SCTID:362680001", "UMLS:C0230120", "VHOG:0000395", "WBbt:0006919" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior", "posterior end of organism" ; oboInOwl:id "UBERON:0001353" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "anal region" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/507"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0006866 ], _:genid116148 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png"^^xsd:anyURI . obo:UBERON_0001355 obo:IAO_0000115 "The profunda femoris artery (also known as the deep femoral artery, or the deep artery of the thigh) is a branch of the femoral artery that, as its name suggests, travels more deeply (posteriorly) than the rest of the femoral artery. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37216", "FMA:20741", "MA:0002027", "NCIT:C32436", "SCTID:181348000", "UMLS:C0226455", "Wikipedia:Deep_femoral_artery" ; oboInOwl:hasExactSynonym "arteria profunda femoris", "profunda femoris artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001355" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "deep femoral artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002060 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray548.png"^^xsd:anyURI . obo:UBERON_0001356 obo:IAO_0000115 "The medial circumflex femoral artery (internal circumflex artery, medial femoral circumflex artery) is an artery in the upper thigh that helps supply blood to the neck of the femur. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37670", "FMA:20799", "MA:0001996", "SCTID:244326008", "Wikipedia:Medial_circumflex_femoral_artery" ; oboInOwl:hasExactSynonym "medial femoral circumflex artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria circumflexa femoris medialis" ; oboInOwl:id "UBERON:0001356" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "medial circumflex femoral artery" ; rdfs:subClassOf _:genid116166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0007119 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c5/Circumflex_femoral_arteries.png"^^xsd:anyURI . obo:UBERON_0001359 obo:IAO_0000115 "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." ; obo:IAO_0000116 "many sources state the CP as sole producer of CSF, but this is disputed [DOI:10.1007/s11064-015-1581-6]" ; obo:UBPROP_0000001 "Portion of organism substance that is a clear fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.[TAO]" ; obo:UBPROP_0000003 "In vertebrates, at early stages of Central Nervous System (CNS) development, the architecture of the brain primordium reveals the presence of the cavity of brain vesicles, which is filled by Embryonic Cerebro-Spinal Fluid (E-CSF). (...) Rat and chick E-CSF proteomes are similar, although rat is more complex in certain groups of proteins, e.g., apolipoproteins, which may be involved in the control of neural diversity, and has soluble enzymes present, just like adult human CSF, but unlike chick E-CSF, revealing phylogenetic brain differences between these groups of vertebrates.[uncertain][VHOG]" ; obo:UBPROP_0000012 "EHDAA2 models this as developing from CP, which is wrong", "the FMA def states that this is subarachnoid spaces only. ZFA def states subarachnoid spaces and brain ventricles, but not SC (and has part_of to brain). Circulation: It circulates from the lateral ventricles to the foramen of Monro (Interventricular foramen), third ventricle, aqueduct of Sylvius (Cerebral aqueduct), fourth ventricle, foramen of Magendie (Median aperture) and foramina of Luschka (Lateral apertures), subarachnoid space over brain and spinal cord. It should be noted that the CSF moves in a pulsatile manner throughout the CSF system with nearly zero net flow. CSF is reabsorbed into venous sinus blood via arachnoid granulations." ; oboInOwl:hasDbXref "BIRNLEX:1798", "BTO:0000237", "CALOHA:TS-0130", "EFO:0000329", "EHDAA2:0004441", "ENVO:02000029", "EV:0100311", "FMA:20935", "GAID:1181", "MA:0002503", "MAT:0000499", "MESH:D002555", "NCIT:C12692", "TAO:0002184", "UMLS:C0007806", "VHOG:0001278", "Wikipedia:Cerebrospinal_fluid", "ZFA:0001626" ; oboInOwl:hasExactSynonym "CSF", "cerebral spinal fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "liquor cerebrospinalis", "spinal fluid" ; oboInOwl:id "UBERON:0001359" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cerebrospinal fluid" ; rdfs:subClassOf obo:UBERON_0007779, [ a owl:Restriction ; owl:onProperty core:filtered_through ; owl:someValuesFrom obo:UBERON_0001886 ], _:genid116172, _:genid116174 . obo:UBERON_0001361 obo:IAO_0000115 "In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor canal (also known as Hunter's canal) and is a continuation of the popliteal vein. It ends at the inferior margin of the inguinal ligament, where it becomes the external iliac vein. [WP,unvetted]." ; obo:UBPROP_0000001 "Either of the primary veins in the hindlimbs which collect blood from the hindlimb region.[AAO]" ; oboInOwl:hasDbXref "AAO:0010237", "EMAPA:17876", "FMA:21185", "GAID:533", "MA:0002118", "MESH:D005268", "NCIT:C12716", "SCTID:362071002", "UMLS:C0015809", "Wikipedia:Femoral_vein", "galen:FemoralVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena femoralis" ; oboInOwl:id "UBERON:0001361" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "femoral vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001316 ] . obo:UBERON_0001363 obo:IAO_0000115 "The great saphenous vein (GSV), also greater saphenous vein, is the large (subcutaneous) superficial vein of the leg and thigh. The terms 'safaina' (Greek) and 'el safin' (Arabic) have both been claimed as the origin for the word 'saphenous'. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0003271", "EMAPA:37147", "FMA:21376", "MA:0002216", "NCIT:C33004", "SCTID:181402008", "UMLS:C0392907", "Wikipedia:Great_saphenous_vein", "galen:GreatSaphenousVein", "galen:GreaterSaphenousVein" ; oboInOwl:hasExactSynonym "greater saphenous vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "large saphenous vein", "long saphenous vein", "vena saphena magna" ; oboInOwl:id "UBERON:0001363" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "great saphenous vein" ; rdfs:subClassOf obo:UBERON_0007318, _:genid116192 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Great_saphenous_vein.png"^^xsd:anyURI . obo:UBERON_0001365 obo:IAO_0000115 "The joint in the bony pelvis between the sacrum and the ilium of the pelvis, which are joined by strong ligaments." ; obo:UBPROP_0000008 "In humans, the sacrum supports the spine and is supported in turn by an ilium on each side" ; oboInOwl:hasDbXref "EMAPA:19300", "FMA:21440", "GAID:268", "MA:0001506", "MESH:D012446", "NCIT:C33507", "SCTID:182199004", "UMLS:C0036036", "Wikipedia:Sacroiliac_joint" ; oboInOwl:hasExactSynonym "articulatio sacro-iliaca", "sacroiliac joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001365" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sacro-iliac joint" ; rdfs:subClassOf obo:UBERON_0011107, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001270 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003690 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray319.png"^^xsd:anyURI . obo:UBERON_0001366 obo:IAO_0000115 "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." ; obo:UBPROP_0000001 "Peritoneum attached to the abdominal wall.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0004459" ; oboInOwl:hasDbXref "AAO:0010816", "EMAPA:16591", "FMA:21451", "SCTID:362700006", "TAO:0005131", "VHOG:0001527", "Wikipedia:Parietal_peritoneum", "ZFA:0005131" ; oboInOwl:hasExactSynonym "parietal serous membrane of peritoneum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "peritoneal cavity lining" ; oboInOwl:id "UBERON:0001366" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "parietal peritoneum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003697 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png"^^xsd:anyURI . obo:UBERON_0001377 obo:IAO_0000115 "One of the muscles belong to the group consisting of the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius)." ; obo:UBPROP_0000001 "The quadriceps is a collective term for the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius). [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.391][VHOG]" ; oboInOwl:hasDbXref "BTO:0001149", "EFO:0001938", "EHDAA2:0001583", "EHDAA:8299", "EMAPA:19146", "FMA:22428", "MA:0002363", "NCIT:C33441", "SCTID:181669009", "UMLS:C0224440", "VHOG:0000828", "Wikipedia:Quadriceps_femoris_muscle", "galen:QuadricepsFemoris" ; oboInOwl:hasExactSynonym "quadriceps", "quadriceps femoris muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus quadriceps femoris", "quadricep muscle", "quadriceps muscle", "quadriceps muscle of the thigh", "quadriceps muscle of thigh" ; oboInOwl:id "UBERON:0001377" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "quadriceps femoris" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ], _:genid116224, _:genid116226, _:genid116228 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001378 obo:UBERON_0001379 obo:UBERON_0001380 obo:UBERON_0014847 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/57/Illu_lower_extremity_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001378 obo:IAO_0000115 "The Rectus femoris muscle is one of the four quadriceps muscles of the human body. (The others are the vastus medialis, the vastus intermedius, and the vastus lateralis. All four combine to form the quadriceps tendon, which inserts into the patella and continues as the patellar ligament. ) The Rectus femoris is situated in the middle of the front of the thigh; it is fusiform in shape, and its superficial fibers are arranged in a bipenniform manner, the deep fibers running straight down to the deep aponeurosis. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0001564", "EMAPA:36266", "FMA:22430", "MA:0002365", "NCIT:C53175", "SCTID:181679006", "UMLS:C0584894", "Wikipedia:Rectus_femoris_muscle" ; oboInOwl:hasExactSynonym "musculus rectos femoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001378" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "rectus femoris" ; rdfs:subClassOf obo:UBERON_0001630, _:genid116238, _:genid116240, _:genid116242, _:genid116244 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/1/14/Rectus_femoris.png"^^xsd:anyURI . obo:UBERON_0001379 obo:IAO_0000115 "The Vastus lateralis (Vastus externus) is the largest part of the Quadriceps femoris. It arises by a broad aponeurosis, which is attached to the upper part of the intertrochanteric line, to the anterior and inferior borders of the greater trochanter, to the lateral lip of the gluteal tuberosity, and to the upper half of the lateral lip of the linea aspera; this aponeurosis covers the upper three-fourths of the muscle, and from its deep surface many fibers take origin. A few additional fibers arise from the tendon of the Glutæus maximus, and from the lateral intermuscular septum between the Vastus lateralis and short head of the Biceps femoris. The fibers form a large fleshy mass, which is attached to a strong aponeurosis, placed on the deep surface of the lower part of the muscle: this aponeurosis becomes contracted and thickened into a flat tendon inserted into the lateral border of the patella, blending with the Quadriceps femoris tendon, and giving an expansion to the capsule of the knee-joint. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "lateralis" ; oboInOwl:hasDbXref "BTO:0001563", "EFO:0001937", "EMAPA:36244", "FMA:22431", "MA:0002402", "NCIT:C53073", "UMLS:C0224444", "Wikipedia:Vastus_lateralis", "galen:VastusLateralis" ; oboInOwl:hasExactSynonym "vastus lateralis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vastus externus" ; oboInOwl:id "UBERON:0001379" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "vastus lateralis" ; rdfs:subClassOf obo:UBERON_0001630, _:genid116248 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/57/Illu_lower_extremity_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001380 obo:IAO_0000115 "The vastus medialis, often called the 'teardrop' muscle, is a medially located muscle of the quadriceps. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "medialis" ; oboInOwl:hasDbXref "BTO:0004913", "EMAPA:36245", "FMA:22432", "MA:0002403", "NCIT:C117736", "Wikipedia:Vastus_medialis", "galen:VastusMedialis" ; oboInOwl:hasExactSynonym "vastus medialis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vastus internus" ; oboInOwl:id "UBERON:0001380" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "vastus medialis" ; rdfs:subClassOf obo:UBERON_0001630, _:genid116253, _:genid116255, _:genid116257, _:genid116259 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/05/Illu_lower_extremity_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001383 obo:IAO_0000115 "A muscle that is part of the region of the hindlimb between the pelvis and ankle." ; obo:UBPROP_0000013 "see notes on UBERON:0000978 for possible confusion over the term 'leg'." ; oboInOwl:hasAlternativeId "UBERON:0003270" ; oboInOwl:hasDbXref "BTO:0000722", "EHDAA:8291", "EMAPA:19144", "EMAPA:19318", "MA:0000672", "RETIRED_EHDAA2:0000974", "Wikipedia:Leg_muscle" ; oboInOwl:hasExactSynonym "leg muscle", "leg muscle organ", "leg skeletal muscle", "leg skeletal muscle tissue", "muscle of hindlimb zeugopod or stylopod", "muscle of thigh or crus", "muscle of upper or lower hindlimb segment", "muscle of upper/lower leg", "muscle organ of leg", "skeletal muscle of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001383" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "muscle of leg" ; rdfs:subClassOf _:genid116267 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0001384 obo:IAO_0000115 "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html." ; obo:IAO_0000116 "TODO - in MA this is asserted to be part_of BOTH frontal and parietal cortex. in ABA these are disjoint. FMA makes no commitment beyond cerebral cortex. Wikipedia says frontal lobe. Check if species difference or difference in definition. Removed relationship: part_of UBERON:0001872 parietal lobe" ; obo:UBPROP_0000001 "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html", "the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP]" ; oboInOwl:hasDbXref "BAMS:M1", "BAMS:MO", "BAMS:MOp", "BM:Tel-Cx-M1", "BTO:0004348", "DHBA:10162", "EFO:0002472", "EMAPA:35704", "FMA:224854", "MA:0000907", "MBA:985", "MESH:D009044", "NCIT:C97339", "NLX:143555", "SCTID:11931008", "UMLS:C0026607", "Wikipedia:Primary_motor_cortex", "neuronames:1910" ; oboInOwl:hasExactSynonym "motor cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Rolando's area", "excitable area", "gyrus precentralis", "motor area", "prefrontal gyrus", "primary motor area", "somatic motor areas", "somatomotor areas" ; oboInOwl:id "UBERON:0001384" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "primary motor cortex" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000956 ], _:genid115987, _:genid116279 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png"^^xsd:anyURI . obo:UBERON_0001385 obo:IAO_0000115 "A muscle that originates in the upper two-thirds of the lateral surface of the tibia and inserts into the medial cuneiform and first metatarsal bones of the foot. Its acts to invert the foot. It is situated on the lateral side of the tibia; it is thick and fleshy above, tendinous below. This muscle overlaps the anterior tibial vessels and deep peroneal nerve in the upper part of the leg. [WP,unvetted]. The M. tibialis cranialis is a muscle that flexes the tarsometatarsus. It originates on the craniodistal aspect of the femur and proximal tibiotarsus and inserts on the cranial surface of the tarsometarsus[EvoWiki]." ; oboInOwl:hasDbXref "BTO:0001382", "EFO:0001385", "EMAPA:35866", "FMA:22532", "MA:0002395", "NCIT:C53079", "SCTID:181696007", "UMLS:C1710423", "Wikipedia:Tibialis_anterior_muscle", "galen:TibialisAnterior" ; oboInOwl:hasExactSynonym "tibialis anterior muscle", "tibialis cranialis", "tibilais cranialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior tibialis", "ibialis anticus", "musculus tibialis anterior" ; oboInOwl:id "UBERON:0001385" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tibialis anterior" ; rdfs:subClassOf obo:UBERON_0008230, _:genid116297, _:genid116299, _:genid116301, _:genid116303, _:genid116305 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray1240.png"^^xsd:anyURI . obo:UBERON_0001388 obo:IAO_0000115 "The most superficial muscle of the triceps surae group, in the posterior portion of the lower hindleg." ; obo:UBPROP_0000001 "The most superficial calf muscle in the posterior part of the leg. [TFD][VHOG]" ; obo:UBPROP_0000003 "The most prominent ventral muscle of the shank is the gastrocnemius, the 'calf' muscle. In mammals, it has two heads, resulting from the fusion of two different phylogenetic predecessors.[well established][VHOG]" ; obo:UBPROP_0000008 "In mammals this muscle has two heads[ISBN:0073040584]" ; obo:UBPROP_0000009 "involved in standing, walking, running and jumping" ; oboInOwl:hasDbXref "BTO:0000506", "EFO:0001413", "EHDAA2:0000701", "EHDAA:8293", "EMAPA:35375", "FMA:22541", "MA:0002306", "NCIT:C32666", "SCTID:181700004", "UMLS:C0242691", "VHOG:0001193", "Wikipedia:Gastrocnemius_muscle", "galen:Gastrocnemius" ; oboInOwl:hasExactSynonym "gastrocnemius muscle", "m. gastrocnemius", "m.gastrocnemius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus gastrocnemius" ; oboInOwl:id "UBERON:0001388" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gastrocnemius" ; rdfs:subClassOf obo:UBERON_0001383, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0040011 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003661 ], _:genid116314, _:genid116317, _:genid116320, _:genid116322, _:genid116324, _:genid116327 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gastrocnemius.png"^^xsd:anyURI . obo:UBERON_0001389 obo:IAO_0000115 "A deep muscle of the triceps surae group, in the superficial posterior compartment of the leg." ; obo:RO_0002161 obo:NCBITaxon_9611 ; obo:UBPROP_0000007 "soleal" ; obo:UBPROP_0000009 "responsible for plantar flexion of the foot" ; oboInOwl:hasDbXref "BTO:0001265", "EFO:0001946", "EMAPA:35786", "FMA:22542", "MA:0002424", "NCIT:C53075", "SCTID:181702007", "UMLS:C0242694", "Wikipedia:Soleus_muscle", "galen:Soleus" ; oboInOwl:hasExactSynonym "soleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001389" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "soleus muscle" ; rdfs:subClassOf obo:UBERON_0001383, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003661 ], _:genid116335, _:genid116337, _:genid116339, _:genid116341, _:genid116344 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/57/Illu_lower_extremity_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001394 obo:IAO_0000115 "Artery that supplies the axilla." ; obo:UBPROP_0000008 "In human anatomy, the axillary artery is a large blood vessel that conveys oxygenated blood to the lateral aspect of the thorax, the axilla (armpit) and the upper limb. Its origin is at the lateral margin of the first rib, before which it is called the subclavian artery. After passing the lower margin of teres major it becomes the brachial artery." ; oboInOwl:hasDbXref "EMAPA:18749", "FMA:22654", "GAID:473", "MA:0002573", "MESH:D001366", "NCIT:C32169", "SCTID:181321001", "UMLS:C0004455", "Wikipedia:Axillary_artery", "galen:AxillaryArtery" ; oboInOwl:hasExactSynonym "arteria axillaris", "axillary part of subclavian artery", "axillary part of trunk of subclavian artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001394" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "axillary artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001533 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/88/Axillary_limits.PNG"^^xsd:anyURI . obo:UBERON_0001397 obo:IAO_0000115 "The subscapular artery, the largest branch of the axillary artery, arises at the lower border of the Subscapularis, which it follows to the inferior angle of the scapula, where it anastomoses with the lateral thoracic and intercostal arteries and with the descending branch of the transverse cervical, and ends in the neighboring muscles. About 4 cm. from its origin it gives off two branches, first the scapular circumflex artery and then the thoracodorsal artery. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37116", "FMA:22677", "MA:0002050", "NCIT:C33650", "SCTID:244311006", "UMLS:C0226422", "Wikipedia:Subscapular_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria subscapularis" ; oboInOwl:id "UBERON:0001397" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "subscapular artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001394 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Axillary_branches.PNG"^^xsd:anyURI . obo:UBERON_0001415 obo:IAO_0000115 "A zone of skin that is part of a pelvis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37282", "FMA:22984", "MA:0000546", "SCTID:181517009" ; oboInOwl:hasExactSynonym "pelvic skin", "pelvis skin", "pelvis zone of skin", "zone of skin of pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001415" ; a owl:Class ; rdfs:label "skin of pelvis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0001416 obo:IAO_0000115 "A zone of skin that is part of an abdomen [Automatically generated definition]." ; oboInOwl:hasDbXref "EFO:0000214", "FMA:22988", "FMA:23000", "MA:0000523", "NCIT:C52758", "SCTID:361707007", "UMLS:C0222166" ; oboInOwl:hasExactSynonym "abdomen skin", "abdomen zone of skin", "abdominal skin", "skin of abdomen proper", "zone of skin of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001416" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "skin of abdomen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0001417 obo:IAO_0000115 "A zone of skin that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37277", "FMA:23021", "FMA:23022", "MA:0000590", "NCIT:C52756", "SCTID:361705004", "UMLS:C0205030" ; oboInOwl:hasExactSynonym "neck (volume) zone of skin", "neck skin", "neck zone of skin", "zone of skin of neck", "zone of skin of neck (volume)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001417" ; a owl:Class ; rdfs:label "skin of neck" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0001418 obo:IAO_0000115 "A zone of skin that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37765", "FMA:23028", "FMA:23029", "MA:0000564", "SCTID:281723000" ; oboInOwl:hasExactSynonym "thoracic skin", "thorax skin", "thorax zone of skin", "zone of skin of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body skin" ; oboInOwl:id "UBERON:0001418" ; a owl:Class ; rdfs:label "skin of thorax" ; owl:equivalentClass _:genid116083 . obo:UBERON_0001419 obo:IAO_0000115 "A zone of skin that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32726", "FMA:23100", "MA:0000694", "NCIT:C53276", "SCTID:314403009", "UMLS:C1282135" ; oboInOwl:hasExactSynonym "limb skin", "limb zone of skin", "zone of skin of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001419" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0001421 obo:IAO_0000115 "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." ; obo:IAO_0000232 "this class describes the organism subdivision, NOT the skeleton within. See also: skeleton of pectoral girdle (UBERON:0007831)." ; obo:RO_0002171 obo:UBERON_0001271 ; obo:UBPROP_0000001 "An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO]" ; obo:UBPROP_0000005 "Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO]" ; oboInOwl:hasDbXref "EMAPA:37856", "FMA:23217", "SCTID:229759004", "VSAO:0000305", "galen:ShoulderGirdle" ; oboInOwl:hasExactSynonym "cingulum membri superioris", "girdle - pectoral" ; oboInOwl:hasNarrowSynonym "cingulum membri superioris", "shoulder girdle", "upper limb girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pectoral girdle", "pectoral region" ; oboInOwl:id "UBERON:0001421" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pectoral girdle region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0007831 ] ; owl:disjointWith obo:UBERON_0007831 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007823 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_0001422 obo:IAO_0000115 "A lymphatic vessel that is part of a face [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:233946", "TAO:0005108", "ZFA:0005108" ; oboInOwl:hasExactSynonym "buccal lymphatic vessel", "face lymph vessel", "face lymphatic vessel", "lymph vessel of face", "lymphatic vessel of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "FL" ; oboInOwl:id "UBERON:0001422" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "facial lymphatic vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011363 ] ; owl:equivalentClass _:genid116113 . obo:UBERON_0001423 obo:IAO_0000115 "The major preaxial endochondral bone in the anterior zeugopod[Phenoscape]." ; obo:UBPROP_0000001 "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the lateral side of the ulna. Its upper end articulates with both the humerus and the ulna, whereas the lower articulates with the carpals.[AAO]" ; oboInOwl:hasDbXref "AAO:0000788", "CALOHA:TS-2199", "EMAPA:19103", "FMA:23463", "GAID:185", "MA:0001357", "MESH:D011884", "NCIT:C12777", "SCTID:181940002", "UMLS:C0034627", "VSAO:0005012", "Wikipedia:Radius_(bone)", "galen:Radius" ; oboInOwl:hasExactSynonym "radius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001423" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Due to the presence of the radius in Tetrpodomorph fish this element is not inherently linked to the presence of digits or flexor musculature. The corresponding bone in the posterior fin/limb is the tibia.[Phenoscape]. In four-legged animals, the radius is the main load-bearing bone of the lower forelimb. Its structure is similar in most terrestrial tetrapods, but it may be fused with the ulna in some mammals (such as horses) and reduced or modified in animals with flippers or vestigial forelimbs [ISBN:0-03-910284-X]" ; rdfs:label "radius bone" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0010703 ], _:genid116438, _:genid116441 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015001 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001424 obo:IAO_0000115 "The major postaxial endochondral bone in the anterior zeugopod[Phenoscape]." ; obo:UBPROP_0000001 "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the medial (inner) side of the radius. The upper end of the ulna articulates with the lower end of the humerus forming a strong hinge joint with the carpals, whereas the lower articulates with the carpals.[AAO]" ; obo:UBPROP_0000007 "ulnar" ; oboInOwl:hasDbXref "AAO:0000789", "EMAPA:19104", "FMA:23466", "GAID:188", "MA:0001358", "MESH:D014457", "NCIT:C12809", "SCTID:181948009", "UMLS:C0041600", "VSAO:0005013", "Wikipedia:Ulna", "galen:Ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001424" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The corresponding bone in the posterior fin/limb is the fibula." ; rdfs:label "ulna" ; rdfs:subClassOf obo:UBERON_0002495, _:genid116138, _:genid116451, _:genid116454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid116135 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg"^^xsd:anyURI . obo:UBERON_0001425 oboInOwl:hasDbXref "FMA:234865", "TAO:0005107", "ZFA:0005107" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PL" ; oboInOwl:id "UBERON:0001425" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "pectoral lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_0001427 obo:IAO_0000115 "Endochondral proximal carpal bone articulating with the radius." ; obo:IAO_0000116 "TODO - check AAO placement; in rodents this is fused with the lunate to make the scapholunate" ; obo:UBPROP_0000001 "One of two element that constitute the basal row of carpals. It articulates proximally with the radius, mesially with the ulnare (or pars intermedia of the ulnare when the ulnare is fused to the intermedium) and distally with the centrale (also recognized by some authors as element Y). This element originates from one or two condensation centers. Occasionally it may fuse to carpal 5(4), the ulnare, or other elements.[AAO]", "the bone of the hand located at the radial side of the carpus and which articulates with the radius, trapezium, trapezoideum, capitate, and lunate bones" ; obo:UBPROP_0000013 "In reptiles, birds, and amphibians, this bone is instead commonly referred to as the radiale, because of its articulation with the radius[WP]" ; oboInOwl:hasDbXref "AAO:0000790", "EMAPA:37660", "FMA:23709", "GAID:180", "MA:0002555", "MESH:D021361", "NCIT:C12854", "SCTID:181958008", "UMLS:C0223724", "Wikipedia:Scaphoid", "galen:Scaphoid" ; oboInOwl:hasExactSynonym "navicular bone of hand", "navicular bone of manus", "navicular of manus", "os carpi radiale", "os naviculare manus", "os scaphoideum", "radial carpal bone", "scaphoid", "scaphoid bone", "scaphoideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "navicular of hand" ; oboInOwl:id "UBERON:0001427" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "radiale" ; rdfs:subClassOf obo:UBERON_0001480 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Carpus.png"^^xsd:anyURI . obo:UBERON_0001428 obo:IAO_0000115 "Endochondral carpal bone articulating with the ulnare and the radiale." ; obo:UBPROP_0000008 "articulating with the ulnare and the radiale[VSAO]. human articulations: radius proximally capitate and hamate distally scaphoid laterally triangular medially" ; oboInOwl:hasBroadSynonym "intermedium" ; oboInOwl:hasDbXref "EMAPA:37659", "FMA:23712", "GAID:181", "MA:0002556", "MESH:D012667", "NCIT:C12786", "SCTID:181959000", "UMLS:C0036624", "VSAO:0005040", "Wikipedia:Lunate_bone", "galen:Lunate" ; oboInOwl:hasExactSynonym "lunar", "lunate", "lunate bone", "os carpi intermedium", "os lunatum", "semilunar bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intermediate carpal bone", "os lunatum", "semilunar", "semilunate" ; oboInOwl:id "UBERON:0001428" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "intermedium" ; rdfs:subClassOf obo:UBERON_0001480, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001427 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002445 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Carpus.png"^^xsd:anyURI . obo:UBERON_0001430 obo:IAO_0000115 "." ; obo:UBPROP_0000008 "located between radiale and first metacarpal[VSAO]. in humans - The capitate articulates with 1st metacarpal distally, scaphoid proximally, trapezoid medially, 2nd metacarpal medially" ; oboInOwl:hasDbXref "AAO:0010634", "EMAPA:36173", "FMA:23721", "MA:0001340", "NCIT:C12857", "SCTID:361780007", "UMLS:C0223736", "VSAO:0005043", "Wikipedia:Trapezium_(bone)", "galen:Trapezium" ; oboInOwl:hasExactSynonym "distal carpal 1", "greater multangular bone", "os trapezium", "trapezial bone", "trapezium", "trapezium bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal 1", "greater multangular", "greater multiangular", "hand distal carpal bone 1", "manus distal carpal bone 1" ; oboInOwl:id "UBERON:0001430" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "distal carpal bone 1" ; rdfs:subClassOf obo:UBERON_0001481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], _:genid116174 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015084 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001431 obo:IAO_0000115 "." ; obo:UBPROP_0000001 "Small element that articulates with the prepollex, metacarpal II(I) and metacarpal III(II). It may be fused to element Y or carpal 3(2).[AAO]", "The trapezoid bone (lesser multangular bone) is a carpal bone in tetrapods, including humans. It is the smallest bone in the distal row. It may be known by its wedge-shaped form, the broad end of the wedge constituting the dorsal, the narrow end the palmar surface; and by its having four articular facets touching each other, and separated by sharp edges. It is homologous with the 'second distal carpal' of reptiles and amphibians. The etymology derives from the Greek trapezion which means 'irregular quadrilateral,' from tra- 'four' and peza 'foot' or 'edge. ' Literally, 'a little table' from trapeza meaning 'table' and -oeides 'shaped.[Wikipedia:Trapezoid_bone]" ; obo:UBPROP_0000008 "located in the distal part of the carpus and articulating with the second metacarpal, the distal carpals 1 and 2 and the radiale.[VSAO] in humans - The capitate articulates with 2nd metacarpal distally, scaphoid proximally, trapezium medially, capitate medially[WP] Amphibians: Small element that articulates with the prepollex, metacarpal II(I) and metacarpal III(II). It may be fused to element Y or carpal 3(2)" ; oboInOwl:hasDbXref "AAO:0000848", "EMAPA:36174", "FMA:23724", "MA:0001341", "NCIT:C12859", "SCTID:361781006", "UMLS:C0223741", "VSAO:0005044", "Wikipedia:Trapezoid_bone", "galen:Trapezoid" ; oboInOwl:hasExactSynonym "distal carpal 2", "lesser multangular bone", "os trapezoideum", "trapezoid", "trapezoid bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal 2", "hand distal carpal bone 2", "lesser multangular", "lesser multiangular", "manus distal carpal bone 2" ; oboInOwl:id "UBERON:0001431" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "distal carpal bone 2" ; rdfs:subClassOf obo:UBERON_0001481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], _:genid116192 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015087 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001432 obo:IAO_0000115 "." ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metacarpal III(II). It may be fused to carpals 2(1), 4(3), 5(4), or other elements.[AAO]" ; obo:UBPROP_0000008 "medially located and articulates with metacarpals 2-4, distal carpal 5 and the intermedium[VSAO] In the human hand, the capitate bone is the largest of the carpal bones, and occupies the center of the wrist - The capitate articulates with seven bones: the scaphoid and lunate proximally, the second metacarpal, third metacarpal, and fourth metacarpal distally, the lesser multangular on the radial side, and the hamate on the ulnar side" ; oboInOwl:hasDbXref "AAO:0000849", "EMAPA:36169", "FMA:23727", "MA:0001342", "NCIT:C12856", "SCTID:181964001", "UMLS:C0223733", "VSAO:0005045", "Wikipedia:Capitate_bone", "galen:Capitate" ; oboInOwl:hasExactSynonym "capitate", "capitate bone", "distal carpal 3", "os magnum (carpus)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal 3", "hand distal carpal bone 3", "magnum", "os capitatum", "os magnum" ; oboInOwl:id "UBERON:0001432" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "distal carpal bone 3" ; rdfs:subClassOf obo:UBERON_0001481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015090 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Carpus.png"^^xsd:anyURI . obo:UBERON_0001433 obo:IAO_0000115 "." ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metacarpal IV(III). It may be fused to carpal 3(2), 5(4), or other elements.[AAO]" ; obo:UBPROP_0000008 "articulates with the lunar, distal carpal 3, the ulnare as well as metacarpals 4 and 5.[VSAO]. In the human hand the lunate proximally the fourth and fifth metacarpals distally the triangular medially the capitate laterally[WP] Amphibians: Small element that articulates anteriorly with metacarpal IV(III). It may be fused to carpal 3(2), 5(4), or other elements" ; oboInOwl:hasDbXref "AAO:0000850", "EMAPA:36172", "FMA:23730", "MA:0001343", "NCIT:C12860", "SCTID:181967008", "UMLS:C0560737", "VSAO:0005046", "Wikipedia:Hamate_bone", "galen:Hamate" ; oboInOwl:hasExactSynonym "distal carpal 4", "hamate", "hamate bone", "unciform bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal 4", "hand distal carpal bone 4", "os hamatum", "unciform", "uncinate" ; oboInOwl:id "UBERON:0001433" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "distal carpal bone 4" ; rdfs:subClassOf obo:UBERON_0001481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid116226 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Carpus.png"^^xsd:anyURI . obo:UBERON_0001434 obo:IAO_0000115 "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." ; obo:RO_0002171 obo:UBERON_0001016 ; obo:UBPROP_0000001 "Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]", "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]", "System that provides physical support to the organism.[AAO]" ; obo:UBPROP_0000003 "By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG]" ; obo:UBPROP_0000007 "skeletal" ; obo:UBPROP_0000012 "GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates" ; oboInOwl:hasDbXref "AAO:0000566", "BTO:0001486", "CALOHA:TS-1320", "EFO:0000806", "EHDAA2:0003168", "EMAPA:35773", "FMA:23881", "MA:0000018", "NCIT:C12788", "TAO:0000434", "UMLS:C0037253", "VHOG:0001254", "VSAO:0000027", "XAO:0003060", "ZFA:0000434" ; oboInOwl:hasExactSynonym "skeleton system" ; oboInOwl:hasNarrowSynonym "set of all bones and joints" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Skelettsystem" ; oboInOwl:id "UBERON:0001434" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "skeletal system" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/The-skeletal-system"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002204 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0001474, obo:UBERON_0002204, obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004288 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004770 ] ) ] . obo:UBERON_0001435 obo:IAO_0000115 "A bone that is part of the carpal skeleton. Examples: scaphoid, lunate, capitate[cjm]." ; obo:UBPROP_0000008 "In tetrapods, the carpals is the sole cluster of the bones in the wrist between the radius and ulna and the metacarpus. The bones of the carpus do not belong to individual fingers (or toes in quadrupeds), whereas those of the metacarpus do. The corresponding part of the foot is the tarsus. The carpal bones allow the wrist to move and rotate vertically, horizontally and laterally. In human anatomy, the main role of the carpus is to facilitate effective positioning of the hand and powerful use of the extensors and flexors of the forearm, but the mobility of individual carpal bones increase the freedom of movements at the wrist." ; oboInOwl:hasDbXref "EMAPA:25056", "FMA:23889", "GAID:179", "MA:0000296", "MESH:D002348", "NCIT:C12688", "SCTID:83936004", "UMLS:C0007285", "Wikipedia:Carpus", "galen:CarpalBone" ; oboInOwl:hasExactSynonym "bone of carpus", "carpal", "carpal skeleton bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpus bone" ; oboInOwl:id "UBERON:0001435" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "carpal bone" ; rdfs:subClassOf obo:UBERON_0003656, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], _:genid116267 ; owl:disjointWith obo:UBERON_0012358 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg"^^xsd:anyURI . obo:UBERON_0001436 obo:IAO_0000115 "A phalanx that is part of a forelimb autopod[Automatically generated definition]." ; obo:UBPROP_0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the four digits of the manus. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the manus, in a medial to lateral sequence, is 2-2-3-3.[AAO]" ; oboInOwl:hasDbXref "AAO:0000947", "EMAPA:32650", "FMA:23914", "MA:0000306", "NCIT:C52771", "SCTID:181976001", "SCTID:361100001", "UMLS:C0223792", "Wikipedia:Phalanges_of_the_hand", "http://mbe.oxfordjournals.org/content/26/3/613/F1.large.jpg" ; oboInOwl:hasExactSynonym "digitus manus phalanx", "finger phalanx", "hand digit phalanx", "hand phalanx", "manual phalanx", "phalanx of digit of hand", "phalanx of digitus manus", "phalanx of finger", "phalanx of fore digit", "phalanx of hand", "phalanx of hand digit", "phalanx of manual digit" ; oboInOwl:hasNarrowSynonym "digital bone of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of finger", "phalanges of fore digit" ; oboInOwl:id "UBERON:0001436" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "phalanx of manus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010688 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ], _:genid116279 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0001437 obo:IAO_0000115 "The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified]." ; obo:UBPROP_0000001 "Cartilaginous expansion at the distal end of an anterior rib or transverse process that serves for the attachment of muscles suspending the pectoral girdle to the vertebral column.[AAO]", "Subdivision of long bone which forms its expanded proximal or distal articular end; together with other the subdivisions of long bone, it constitutes the long bone. Examples: proximal epiphysis of humerus, distal epiphysis of femur." ; obo:UBPROP_0000007 "epiphyseal", "epiphysial" ; oboInOwl:hasDbXref "AAO:0000742", "BTO:0000413", "EMAPA:35508", "FMA:24012", "MA:0001362", "MESH:D004838", "NCIT:C32529", "NCIT:C52722", "SCTID:244701002", "UMLS:C1708734", "Wikipedia:Epiphysis" ; oboInOwl:hasExactSynonym "bone epiphysis", "end of long bone", "epiphyses", "long bone epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001437" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "epiphysis" ; rdfs:seeAlso obo:UBERON_0006776 ; rdfs:subClassOf obo:UBERON_0005055, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002495 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg"^^xsd:anyURI . obo:UBERON_0001438 obo:IAO_0000115 "Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]." ; obo:IAO_0000116 "todo - decide - adjacent to or containing epiphyseal plate? AO Notes: FMA the metaphysis is part of the diaphysis, but not in MA." ; obo:UBPROP_0000001 "Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]" ; oboInOwl:hasDbXref "EMAPA:35509", "FMA:24014", "MA:0001363", "NCIT:C52723", "SCTID:304581004", "UMLS:C0222671", "Wikipedia:Metaphysis" ; oboInOwl:hasExactSynonym "diaphyseal end of long bone", "long bone metaphysis", "metaphyses" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001438" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "metaphysis" ; rdfs:subClassOf obo:UBERON_0005055, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004769 ], _:genid116301, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002495 ] . obo:UBERON_0001439 obo:IAO_0000115 "The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae." ; oboInOwl:hasDbXref "EMAPA:35250", "FMA:24018", "MA:0001461", "NCIT:C52714", "SCTID:361728003", "UMLS:C0222661", "Wikipedia:Compact_bone", "galen:CorticalBone" ; oboInOwl:hasExactSynonym "bony cortex", "compact bone", "compact bone tissue", "cortical bone", "cortical bone tissue", "cortical region of bone", "substantia compacta", "substantia compacta (pars ossea)", "substantia corticalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001439" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "MP distinguishes compact/cortical bone. in other AOs they are syns" ; rdfs:label "compact bone tissue" ; rdfs:subClassOf obo:UBERON_0002481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002482 ] ; owl:disjointWith obo:UBERON_0002483 . obo:UBERON_0001440 obo:IAO_0000115 "The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle." ; obo:IAO_0000116 "TODO - find a home for: FMA:24139 ! skeleton of upper limb" ; obo:RO_0002475 obo:UBERON_0001441 ; obo:UBPROP_0000001 "Skeletal structure of the paired, anterior appendages.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000202", "EHDAA2:0002222", "EMAPA:32623", "FMA:24142", "VHOG:0001256", "VSAO:0000151", "XAO:0003061" ; oboInOwl:hasExactSynonym "bones of upper limb", "fore limb skeleton", "forelimb skeleton", "free upper limb skeleton", "ossa membri superioris", "pectoral limb skeleton", "set of bones of upper limb", "skeleton of forelimb", "skeleton of free upper limb", "skeleton of pectoral limb", "skeleton of upper limb", "upper limb skeleton" ; oboInOwl:hasNarrowSynonym "wing skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001440" ; a owl:Class ; rdfs:label "forelimb skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012475 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0007831 ], _:genid116633 ; owl:equivalentClass _:genid116314 . obo:UBERON_0001441 obo:IAO_0000115 "Subdivision of skeleton consisting of all skeletal elements in an hindlimb region." ; obo:UBPROP_0000001 "Skeletal structure of the paired, posterior appendages.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000217", "EHDAA2:0002226", "EMAPA:32633", "FMA:24144", "VHOG:0001255", "VSAO:0000152", "XAO:0003062" ; oboInOwl:hasExactSynonym "bones of lower limb", "free lower limb skeleton", "hind limb skeleton", "hind-limb skeleton", "hindlimb skeleton", "lower limb skeleton", "ossa membri inferioris", "set of bones of lower limb", "skeleton of free lower limb", "skeleton of lower limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001441" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "TOOD - find a home for: FMA:24140" ; rdfs:label "hindlimb skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012476 ], _:genid116337, _:genid116652 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0001442 obo:IAO_0000115 "Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0002227", "EMAPA:32643", "FMA:24159", "VSAO:0005020" ; oboInOwl:hasExactSynonym "anterior autopodium skeleton", "bones of hand", "fore autopod skeleton", "forelimb autopod skeleton", "hand region skeleton", "hand skeleton", "manual skeleton", "manus skeleton", "ossa manus", "set of bones of hand", "skeleton of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior autopodium", "manus" ; oboInOwl:id "UBERON:0001442" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "here 'manus' includes both the wrist region, metatarsal region and acropodial region" ; rdfs:label "skeleton of manus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ], _:genid116671 ; owl:disjointWith obo:UBERON_0001445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0001443 obo:IAO_0000115 "Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]." ; obo:IAO_0000116 "FMA:24216 present in FMA1, but gone in subsequent versions" ; obo:RO_0002171 obo:UBERON_0000916 ; obo:UBPROP_0000007 "pectoral", "thoracic" ; oboInOwl:hasDbXref "BTO:0001368", "CALOHA:TS-1039", "EFO:0000965", "EMAPA:37232", "EV:0100010", "FMA:9576", "GAID:91", "MA:0000031", "MAT:0000295", "MESH:D013909", "MIAA:0000295", "NCIT:C12799", "NCIT:C25389", "UMLS:C0817096", "UMLS:C1527391", "Wikipedia:Chest", "galen:Chest", "galen:Thorax" ; oboInOwl:hasExactSynonym "anterolateral part of thorax", "front of thorax", "pectus", "ventral part of thoracic region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thoracic body wall", "thorax" ; oboInOwl:id "UBERON:0001443" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "chest" ; rdfs:subClassOf obo:UBERON_0009569, _:genid116685 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Chest.jpg"^^xsd:anyURI . obo:UBERON_0001444 oboInOwl:hasDbXref "FMA:24218", "SCTID:123852005", "XAO:0000040" ; oboInOwl:hasExactSynonym "head subdivision" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "head region", "region of head" ; oboInOwl:id "UBERON:0001444" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of head" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] . obo:UBERON_0001445 obo:IAO_0000115 "Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0002228", "FMA:24222", "VSAO:0005021" ; oboInOwl:hasExactSynonym "foot region skeleton", "foot skeleton", "pedal skeleton", "pes skeleton", "posterior autopodium skeleton", "set of bones of foot", "skeleton of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pes", "posterior autopodium" ; oboInOwl:id "UBERON:0001445" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "here 'pes' includes both the ankle region, metatarsals and acropodial region" ; rdfs:label "skeleton of pes" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ], _:genid116699 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0001446 obo:IAO_0000115 "The major postaxial endochondral bone in the posterior zeugopod[Phenoscape]." ; obo:UBPROP_0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a rather more slender bone than the tibia but of about the same length.[AAO]" ; obo:UBPROP_0000007 "fibular" ; oboInOwl:hasDbXref "AAO:0000891", "BTO:0002346", "CALOHA:TS-2203", "EFO:0003052", "EMAPA:19141", "FMA:24479", "GAID:202", "MA:0001360", "MESH:D005360", "NCIT:C12718", "SCTID:302529003", "UMLS:C0016068", "Wikipedia:Fibula", "galen:Fibula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001446" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "fibula" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001115 ; owl:someValuesFrom obo:UBERON_0010720 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015013 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Illu_lower_extremity.jpg"^^xsd:anyURI . obo:UBERON_0001447 obo:IAO_0000115 "A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia." ; obo:UBPROP_0000008 "In primitive tetrapods, such as Trematops, the tarsus consists of three rows of bones. There are three proximal tarsals, the tibiale, intermedium, and fibulare, named for their points of articulation with the bones of the lower limb. These are followed by a second row of four bones, referred to as the centralia (singular: centrale), and then a row of five distal tarsals, each articulating with a single metatarsal. In the great majority of tetrapods, including all of those alive today, this simple pattern is modified by the loss and fusion of various of the bones.[3] In reptiles and mammals, there are normally just two proximal tarsals, the calcaneus (equivalent to the amphibian fibulare) and the talus (probably derived from a fusion of multiple bones). In mammals, including humans, the talus forms a hinge joint with the tibia, a feature especially well developed in the artiodactyls. The calcaneus is also modified, forming a heel for the attachment of the Achilles tendon. Neither of these adaptations is found in reptiles, which have a relatively simple structure to both bones.[3] The fifth distal tarsal disappears relatively early in evolution, with the remainder becoming the cuneiform and cuboid bones. Reptiles usually retain two centralia, while mammals typically have only one (the navicular).[3] In birds, the tarsus has disappeared, with the proximal tarsals having fused with the tibia, the centralia having disappeared, and the distal bones having fused with the metatarsals to form a single tarsometatarsus bone, effectively giving the leg a third segment" ; oboInOwl:hasDbXref "BTO:0002343", "EMAPA:25072", "FMA:24491", "GAID:194", "MA:0000297", "MESH:D013639", "NCIT:C12796", "SCTID:108372004", "UMLS:C0039316", "galen:TarsalBone" ; oboInOwl:hasExactSynonym "ankle bone", "bone of ankle", "bone of tarsal skeleton", "bone of tarsus", "ossa tarsalia", "ossa tarsi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bony tarsus", "hind mesopodium", "tarsal", "tarsus osseus" ; oboInOwl:id "UBERON:0001447" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tarsal bone" ; rdfs:subClassOf obo:UBERON_0003656, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010541 ] ; owl:disjointWith obo:UBERON_0012359 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg"^^xsd:anyURI . obo:UBERON_0001448 obo:IAO_0000115 "The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes. Lacking individual names, the metatarsal bones are numbered from the medial side (side of big toe): the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the manus. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0002347", "EMAPA:32940", "EMAPA:36159", "FMA:24492", "GAID:193", "MA:0000303", "MESH:D008682", "NCIT:C12752", "SCTID:302532000", "UMLS:C0025584", "Wikipedia:Metatarsal_bone", "galen:Metatarsal" ; oboInOwl:hasExactSynonym "metatarsal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ossa metatarsalia", "ossa metatarsi" ; oboInOwl:id "UBERON:0001448" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "metatarsal bone" ; rdfs:subClassOf obo:UBERON_0003821, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010545 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001447 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000983 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png"^^xsd:anyURI . obo:UBERON_0001449 obo:IAO_0000115 "A phalanx that is part of a hindlimb autopod[Automatically generated definition]." ; obo:UBPROP_0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the five digits of the pes. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the pes, in a medial to lateral sequence, is 2(1)-2-3-4(3)-3(2).[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0004272" ; oboInOwl:hasBroadSynonym "digital bone of pes" ; oboInOwl:hasDbXref "AAO:0000930", "EMAPA:32941", "FMA:24493", "MA:0000305", "NCIT:C52772", "SCTID:302533005", "UMLS:C0584876", "Wikipedia:Phalanges_of_the_foot", "ncithesaurus:Phalanx_of_the_Foot" ; oboInOwl:hasExactSynonym "digitus pedis phalanx", "foot digit phalanx", "foot phalanx", "pedal phalanx", "phalanx of digit of foot", "phalanx of digitus pedis", "phalanx of foot digit", "phalanx of hind digit", "phalanx of pes", "phalanx of toe", "toe phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of toe", "phalanges of hind digit" ; oboInOwl:id "UBERON:0001449" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "phalanx of pes" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010696 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101466 ], _:genid116438 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0001450 obo:IAO_0000115 "The postaxial bone of the proximal tarsals series[Phenoscape]." ; obo:UBPROP_0000007 "calcaneal" ; obo:UBPROP_0000008 "synonymous with the fibulare of basal tetrapods." ; oboInOwl:hasDbXref "BTO:0002355", "EMAPA:19134", "FMA:24496", "MA:0001348", "MESH:D002111", "NCIT:C32250", "SCTID:182099002", "UMLS:C0006655", "VSAO:0005016", "Wikipedia:Calcaneus", "galen:Calcaneum" ; oboInOwl:hasExactSynonym "calcaneal bone", "calcaneum", "calcaneus bone", "os calcis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calcanei", "fibulare", "heel bone", "os tarsi fibulare" ; oboInOwl:id "UBERON:0001450" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "calcaneus" ; rdfs:subClassOf obo:UBERON_0011679, [ a owl:Restriction ; owl:onProperty obo:BSPO_0001115 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010842 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid116454 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG"^^xsd:anyURI . obo:UBERON_0001451 obo:IAO_0000115 "The oval-shaped tarsal bone found between the talus and the 3 cuneiform bones." ; obo:UBPROP_0000001 "Oval tarsal element that is located on the center of the mesopodium. It articulates with all other elements of the tarsus except tarsal 5.[AAO]" ; obo:UBPROP_0000008 "connections vary depending on species. AAO: Oval tarsal element that is located on the center of the mesopodium. It articulates with all other elements of the tarsus except tarsal 5. In humans: there is a cuboid instead of distal tarsal 4 and 5 - may articulate laterally with the cuboid" ; oboInOwl:hasBroadSynonym "centrale" ; oboInOwl:hasDbXref "AAO:0000924", "BTO:0002356", "EMAPA:36180", "FMA:24499", "MA:0001349", "NCIT:C33162", "SCTID:182100005", "UMLS:C0223947", "Wikipedia:Navicular_bone", "galen:Navicular" ; oboInOwl:hasExactSynonym "centrale (hind)", "navicular", "navicular bone of foot", "navicular of foot", "navicular of pes", "os naviculare", "os naviculare pedis", "os tarsi centrale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "central tarsal bone", "os naviculare" ; oboInOwl:id "UBERON:0001451" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "navicular bone of pes" ; rdfs:subClassOf obo:UBERON_0001447, obo:UBERON_0012131, [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0002395 ], _:genid116789 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray276.png"^^xsd:anyURI . obo:UBERON_0001452 obo:IAO_0000115 "Endochondral tarsal bone articulating with centralia and metatarsal 1." ; obo:UBPROP_0000001 "Small element that articulates with the prehallux, metatarsal I and element Y. It may be fused to tarsal 2.[AAO]" ; oboInOwl:hasDbXref "AAO:0000918", "BTO:0002360", "EMAPA:36176", "FMA:24518", "MA:0001352", "NCIT:C32840", "SCTID:182116007", "UMLS:C1512869", "VSAO:0005052", "Wikipedia:Medial_cuneiform_bone", "galen:MedialCuneiform", "http://palaeos.com/vertebrates/glossary/images/450x218xEctocuneiform.gif.pagespeed.ic.kaiuLYQELL.png" ; oboInOwl:hasExactSynonym "cuneiforme 1", "distal tarsal 1 bone", "entocuneiforme", "first cuneiform", "first cuneiform bone", "medial cuneiform", "medial cuneiform bone", "os cuneiforme mediale", "os tarsale I", "tarsal 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "1st cuneiform", "distal tarsal 1", "foot distal carpal bone 1", "os cuneiform primum", "os cuneiforme mediale", "os cuneiforme primum", "ossa cuneiforme mediale" ; oboInOwl:id "UBERON:0001452" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "distal tarsal bone 1" ; rdfs:subClassOf obo:UBERON_0010721, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015103 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003650 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001451 ] ; owl:disjointWith obo:UBERON_0001454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015102 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray290.png"^^xsd:anyURI . obo:UBERON_0001453 obo:IAO_0000115 "Endochondral tarsal bone articulating with centralia and metatarsal 2." ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metatarsal II. It may be fused to tarsal 1 or to tarsal 3.[AAO]" ; oboInOwl:hasDbXref "AAO:0000919", "BTO:0002359", "EMAPA:36177", "FMA:24519", "MA:0001353", "NCIT:C33116", "SCTID:179512006", "UMLS:C1513292", "VSAO:0005053", "Wikipedia:Intermediate_cuneiform_bone", "galen:IntermediateCuneiform" ; oboInOwl:hasExactSynonym "cuneiforme 2", "distal tarsal 2 bone", "intermediate cuneiform", "mesocuneiforme", "middle cuneiform", "middle cuneiform bone of foot", "os cuneiforme intermedium", "os tarsale II", "second cuneiform bone", "second cuneiform bone of foot", "tarsal 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd cuneiform", "distal tarsal 2", "foot distal carpal bone 2", "intermediate cuneiform bone", "os cuneiforme intermedium", "os cuneiforme secundum" ; oboInOwl:id "UBERON:0001453" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "The intermediate cuneiform (also known as second cuneiform / middle cuneiform) is shaped like a wedge, the thin end pointing downwards. It is situated between the other two cuneiforms (the medial and lateral cuneiforms), and articulates with the navicular posteriorly, the second metatarsal anteriorly and with the other cuneiforms on either side. [WP,unvetted]" ; rdfs:label "distal tarsal bone 2" ; rdfs:subClassOf obo:UBERON_0010721, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015106 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003651 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015105 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png"^^xsd:anyURI . obo:UBERON_0001454 obo:IAO_0000115 "Endochondral tarsal bone articulating with centralia and metatarsal 3." ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metatarsal III. It may be fused to tarsal 2.[AAO]" ; obo:UBPROP_0000005 "In some types, the cuneiform is found as two or three bones, in which case the more anterior ('dorsal' in dorsal/plantar terminology) is the ectocuneiform, while the more posterior or plantar bones are the mesocuneiform and entocuneiform.[Palaeos]" ; oboInOwl:hasDbXref "AAO:0000920", "BTO:0002358", "EMAPA:36178", "FMA:24520", "MA:0001354", "NCIT:C32554", "SCTID:182117003", "UMLS:C1517036", "VSAO:0005054", "Wikipedia:Lateral_cuneiform_bone", "galen:LateralCuneiform" ; oboInOwl:hasExactSynonym "cuneiforme 3", "distal tarsal 3 bone", "ectocuneiforme", "external cuneiform", "external cuneiform bone of foot", "lateral cuneiform", "lateral cuneiform bone", "os cuneiforme laterale", "os tarsale III", "tarsal 3", "third cuneiform bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd cuneiform", "distal tarsal 3", "foor distal carpal bone 3", "os cuneiforme laterale", "os cuneiforme tertium", "ossa cuneiforme laterale" ; oboInOwl:id "UBERON:0001454" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "The lateral cuneiform (also known as third cuneiform / external cuneiform) intermediate in size between the other two cuneiform bones, is also wedge-shaped, the base being uppermost. It occupies the center of the front row of the tarsal bones, between the second cuneiform medially, the cuboid laterally, the navicular posteriorly and the third metatarsal in front. [WP,unvetted]" ; rdfs:label "distal tarsal bone 3" ; rdfs:subClassOf obo:UBERON_0010721, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015109 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003652 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015108 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png"^^xsd:anyURI . obo:UBERON_0001455 obo:IAO_0000115 "A tarsal bone that is formed from distal tarsals 4 and 5. [WP,modified]." ; obo:UBPROP_0000013 "NominaAnatomicaVeterinaria uses os cuboideum as an official synonym for distal tarsal IV, but some sources also use this as the label for the human cuboid bone which is regarded to be formed from tarsals IV and V. We therefore decline to use exact syns in either case." ; oboInOwl:hasDbXref "BTO:0002357", "EMAPA:36175", "FMA:24527", "MA:0001355", "NCIT:C32414", "SCTID:182101009", "UMLS:C0376381", "Wikipedia:Cuboid_bone", "galen:Cuboid" ; oboInOwl:hasExactSynonym "cuboid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cuboideum", "distal tarsal bones 4 and 5", "foot distal tarsal bone 4 and 5", "os cuboideum", "os tarsale IV et V" ; oboInOwl:id "UBERON:0001455" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "cuboid bone" ; rdfs:subClassOf obo:UBERON_0010721 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010721 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0010737 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0010738 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/18/Gray274.png"^^xsd:anyURI . obo:UBERON_0001456 obo:IAO_0000115 "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." ; obo:UBPROP_0000001 "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face.", "The area that extends from the median ocellus to the oral foramen[HAO]." ; obo:UBPROP_0000007 "facial" ; obo:UBPROP_0000011 "The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence)" ; oboInOwl:hasDbXref "BTO:0003369", "CALOHA:TS-2216", "EMAPA:32763", "FMA:24728", "GAID:64", "HAO:0000316", "MA:0002473", "MESH:D005145", "NCIT:C13071", "SCTID:302549007", "UMLS:C0015450", "Wikipedia:Face", "galen:Face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facia/facies", "visage" ; oboInOwl:id "UBERON:0001456" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "face" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000033 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg"^^xsd:anyURI . obo:UBERON_0001457 obo:IAO_0000115 "A zone of skin that is part of a eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37536", "FMA:24760", "MA:0001256", "NCIT:C52718", "SCTID:245947005", "UMLS:C0222088" ; oboInOwl:hasExactSynonym "blepharon zone of skin", "eyelid skin", "eyelid zone of skin", "zone of skin of blepharon", "zone of skin of eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001457" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of eyelid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0001458 obo:IAO_0000115 "A zone of skin that is part of a lip [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37643", "FMA:24764", "MA:0001579", "NCIT:C12291", "SCTID:244092005", "UMLS:C0222101" ; oboInOwl:hasExactSynonym "lip skin", "lip zone of skin", "zone of skin of lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin of lips" ; oboInOwl:id "UBERON:0001458" ; a owl:Class ; rdfs:label "skin of lip" ; rdfs:subClassOf obo:UBERON_0000014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0001459 obo:IAO_0000115 "A zone of skin that is part of a external ear [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35301", "FMA:24775", "MA:0001233", "NCIT:C49481", "SCTID:244073008", "UMLS:C0222110" ; oboInOwl:hasExactSynonym "auricular region of head zone of skin", "auricular region zone of skin", "ear skin", "external ear skin", "external ear zone of skin", "outer ear zone of skin", "zone of skin of auricular region", "zone of skin of auricular region of head", "zone of skin of external ear", "zone of skin of outer ear" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001459" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of external ear" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_0001460 obo:IAO_0000115 "The part of the forelimb extending from the shoulder to the autopod[cjm]." ; obo:IAO_0000116 "currently declared as overlapping hand, as AOs disagree over whether some wrist parts are in the arm or hand" ; obo:IAO_0000232 "this class refers to the combination of the stylopod and zeugopod of a forelimb. Sometimes (cf FMA), 'arm' denotes the stylopod only; sometimes (cf MA), 'arm' denotes the part of the forelimb covering both (i.e. shoulder to hand). Also note distinction between arm and forelimb: hand is part of forelimb, but not part of arm" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001435", "CALOHA:TS-2204", "EFO:0001410", "EHDAA2:0000140", "EHDAA:4164", "EHDAA:6210", "EHDAA:8275", "EMAPA:17413", "GAID:52", "MA:0000033", "MESH:D001132", "VHOG:0000339", "Wikipedia:Arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brachium", "upper extremity" ; oboInOwl:id "UBERON:0001460" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "arm" ; rdfs:subClassOf obo:UBERON_0006058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0002398 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001467 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Upperarm.jpg"^^xsd:anyURI . obo:UBERON_0001461 obo:IAO_0000115 "The elbow is the region surrounding the elbow-joint-the ginglymus or hinge joint in the middle of the arm. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna, and the inner aspect of the elbow is called the antecubital fossa. [WP,unvetted,human-specific]." ; obo:UBPROP_0000007 "cubital" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group" ; oboInOwl:hasDbXref "CALOHA:TS-2222", "EFO:0003069", "EHDAA2:0000429", "EHDAA:4166", "EHDAA:6212", "EMAPA:17414", "FMA:24901", "GAID:54", "MA:0000036", "MESH:D004550", "SCTID:76248009", "VHOG:0000340", "Wikipedia:Elbow", "galen:Elbow" ; oboInOwl:hasExactSynonym "cubital region", "elbow limb segment", "elbow region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio cubiti" ; oboInOwl:id "UBERON:0001461" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "elbow" ; rdfs:subClassOf obo:UBERON_0002529, _:genid116941 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG"^^xsd:anyURI . obo:UBERON_0001463 obo:IAO_0000115 "1st (preaxial) digit of the manus[Wikipedia]." ; obo:UBPROP_0000008 "Not present in Anurans (Phenotype RCN Oct 2012)", "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." ; oboInOwl:hasBroadSynonym "digitus 1", "digitus I", "digitus primus", "digitus primus [I]" ; oboInOwl:hasDbXref "AAO:0010639", "EHDAA2:0000511", "EMAPA:17429", "FMA:24938", "GAID:58", "MA:0000454", "MESH:D013933", "NCIT:C52834", "SCTID:302540006", "SCTID:69603001", "UMLS:C0040067", "Wikipedia:Thumb" ; oboInOwl:hasExactSynonym "digit 1 of fore-paw", "digit 1 of manus", "finger 1", "first digit of hand", "fore digit I", "fore limb digit 1", "hand digit 1", "manual digit 1", "manual digit I", "pollex" ; oboInOwl:hasNarrowSynonym "alula", "forelimb dewclaw", "hand digit 1", "thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "first finger" ; oboInOwl:id "UBERON:0001463" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "manual digit 1" ; rdfs:subClassOf obo:UBERON_0002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5001463 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0002398 ], _:genid116949 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Thumb-up.jpg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/2/2c/Thumbs_up.jpg"^^xsd:anyURI . obo:UBERON_0001464 obo:IAO_0000115 "The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified]." ; obo:UBPROP_0000003 "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" ; obo:UBPROP_0000007 "coxal" ; obo:UBPROP_0000012 "See notes for shoulder. in BTO this is part of the abdomen - this creates an inconsistency if limb and abdomen are spatially disjoint" ; oboInOwl:hasDbXref "BTO:0001457", "CALOHA:TS-2226", "EFO:0001929", "EHDAA2:0000783", "EHDAA:5153", "EHDAA:6178", "EMAPA:17490", "FMA:24964", "GAID:47", "MA:0000045", "MESH:D006615", "NCIT:C64193", "SCTID:302543008", "UMLS:C0019552", "VHOG:0000346", "Wikipedia:Hip", "galen:Hip" ; oboInOwl:hasExactSynonym "hip region", "regio coxae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coxa" ; oboInOwl:id "UBERON:0001464" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hip" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ], _:genid116971 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Hip.jpg"^^xsd:anyURI . obo:UBERON_0001465 obo:IAO_0000115 "A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod." ; oboInOwl:hasDbXref "BTO:0003595", "CALOHA:TS-2220", "EHDAA2:0000895", "EHDAA:5159", "EHDAA:6184", "EMAPA:17493", "FMA:24974", "GAID:48", "MA:0000046", "MESH:D007717", "SCTID:361291001", "VHOG:0000347", "galen:Knee" ; oboInOwl:hasExactSynonym "knee region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001465" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "knee" ; rdfs:subClassOf obo:UBERON_0002529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Male_Knee_by_David_Shankbone.jpg"^^xsd:anyURI . obo:UBERON_0001466 obo:IAO_0000115 "A digit that is part of a pes (foot)." ; oboInOwl:hasAlternativeId "UBERON:0000027" ; oboInOwl:hasDbXref "AAO:0000888", "BTO:0002348", "EMAPA:32649", "FMA:25046", "GAID:44", "MA:0000048", "NCIT:C33788", "SCTID:116667001", "UMLS:C0040357", "Wikipedia:Toe", "XAO:0003035", "galen:Toe" ; oboInOwl:hasExactSynonym "digit of foot", "digit of terminal segment of lower limb", "digiti pedis", "digitus pedis", "foot digit", "hind digit", "hind_digit", "hindlimb digit", "pedal digit (phalangeal portion) plus soft tissue", "pes digit", "toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digiti pedis", "digitipedis" ; oboInOwl:id "UBERON:0001466" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pedal digit" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5001466 ], _:genid116986 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Toes.jpg"^^xsd:anyURI . obo:UBERON_0001467 obo:IAO_0000115 "A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle)." ; obo:UBPROP_0000003 "(...) endochondral elements of the early tetrapod shoulder develop from two centers of ossification, giving rise to a scapula and a 'coracoid'.[well established][VHOG]" ; obo:UBPROP_0000012 "In FMA, the shoulder is part of the pectoral girdle region. in MA, shoulder structures like shoulder joints, bones, nerves etc are part of the shoulder and the forelimb. E.g. humerus is a shoulder bone" ; oboInOwl:hasDbXref "CALOHA:TS-2229", "EFO:0003068", "EHDAA2:0001834", "EHDAA:4180", "EHDAA:6228", "EMAPA:17421", "FMA:25202", "GAID:60", "MA:0000038", "MESH:D012782", "NCIT:C25203", "SCTID:361103004", "UMLS:C0037004", "VHOG:0000342", "Wikipedia:Shoulder", "galen:Shoulder" ; oboInOwl:hasExactSynonym "shoulder region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio humeri" ; oboInOwl:id "UBERON:0001467" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "shoulder" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0016884 ], _:genid117002 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/90/Shoulderjoint.PNG"^^xsd:anyURI . obo:UBERON_0001468 obo:IAO_0000115 "The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments." ; obo:UBPROP_0000012 "FMA has 'intervertebral joint' as a GAT, and has two distinct classes 'intervertebral symphysis' and 'intervertebral syndesmosis', but note that the latter do not connect the centra" ; oboInOwl:hasBroadSynonym "vertebral joint" ; oboInOwl:hasDbXref "EMAPA:37622", "FMA:25511", "MA:0001514", "NCIT:C49577", "SCTID:244512000", "UMLS:C1182940" ; oboInOwl:hasExactSynonym "inter-centrum joint", "inter-vertebral joint", "intervertebral symphysis", "joint of vertebral body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001468" ; a owl:Class ; rdfs:label "intervertebral joint" ; rdfs:subClassOf obo:UBERON_0002216, _:genid117014, _:genid117016 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 _:genid116685 ) ] . obo:UBERON_0001469 obo:IAO_0000115 "The sternoclavicular articulation is a double arthrodial joint composed of two portions separated by an articular disc. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib, visible from the outside as the suprasternal notch. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, which is considerably thicker than that on the latter bone. The ligaments of this joint are: Articular capsule Anterior sternoclavicular ligament Posterior sternoclavicular ligament Interclavicular ligament Costoclavicular ligament Articular disk [WP,unvetted]." ; oboInOwl:hasBroadSynonym "sternoclavicular" ; oboInOwl:hasDbXref "EMAPA:19203", "FMA:25883", "GAID:270", "MA:0001507", "MESH:D013247", "NCIT:C33615", "SCTID:182165002", "UMLS:C0038291", "Wikipedia:Sternoclavicular_articulation" ; oboInOwl:hasExactSynonym "sterno clavicular joint", "sternoclavicular articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio sternoclavicularis" ; oboInOwl:id "UBERON:0001469" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "sternoclavicular joint" ; rdfs:subClassOf obo:UBERON_0011108, _:genid117031, _:genid117033 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray325.png"^^xsd:anyURI . obo:UBERON_0001470 obo:IAO_0000115 "The glenohumeral joint, commonly known as the shoulder joint, is a multiaxial synovial ball and socket joint and involves articulation between the glenoid fossa of the scapula (shoulder blade) and the head of the humerus (upper arm bone). [WP,unvetted]." ; obo:IAO_0000116 "note that in this ontology 'glenoid fossa' is a cavity (consistent with FMA) - consider adding a class for the surface of the scapula that is adjacent to this cavity, and making a more explicit connects relationship" ; obo:UBPROP_0000012 "in FMA, this is part of the bony pectoral girdle, alongside the skeleton of pectoral girdle" ; oboInOwl:hasBroadSynonym "joint of shoulder", "shoulder joint" ; oboInOwl:hasDbXref "EMAPA:19105", "FMA:25912", "GAID:269", "MA:0000459", "MESH:D012785", "NCIT:C33548", "SCTID:182168000", "UMLS:C0037009", "VHOG:0001002", "Wikipedia:Glenohumeral_joint", "galen:ShoulderJoint" ; oboInOwl:hasExactSynonym "articulatio humeri", "humeral joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "humeroscapular joint" ; oboInOwl:id "UBERON:0001470" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "glenohumeral joint" ; rdfs:subClassOf obo:UBERON_0011139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004753 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006657 ], _:genid117047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray327.png"^^xsd:anyURI . obo:UBERON_0001471 obo:IAO_0000115 "The loose fold of skin that covers the penis." ; oboInOwl:hasDbXref "EV:0100109", "FMA:27648", "MA:0001744", "SCTID:39059001", "VHOG:0001342" ; oboInOwl:hasExactSynonym "foreskin of penis", "penis foreskin", "preputial skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001471" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of prepuce of penis" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000989 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:UBERON_0001472 obo:IAO_0000115 "The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37801", "FMA:29713", "MA:0002257", "SCTID:294653003", "Wikipedia:Vaginal_venous_plexus" ; oboInOwl:hasExactSynonym "venous vaginal plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus venosus vaginalis" ; oboInOwl:id "UBERON:0001472" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "vaginal venous plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png"^^xsd:anyURI . obo:UBERON_0001473 obo:IAO_0000115 "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." ; obo:UBPROP_0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]", "A vessel that contains or conveys lymph.[AAO]" ; obo:UBPROP_0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011005", "BTO:0000752", "CALOHA:TS-2102", "EFO:0000873", "EMAPA:35532", "FMA:30315", "MA:0000138", "MAT:0000443", "MESH:D042601", "NCIT:C33038", "SCTID:279089004", "TAO:0005105", "UMLS:C0229889", "VHOG:0001249", "Wikipedia:Lymphatic_vessel", "XAO:0000375" ; oboInOwl:hasExactSynonym "lymph vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vas lymphaticum" ; oboInOwl:id "UBERON:0001473" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lymphatic vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006558 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002391 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002405 ] ; owl:disjointWith obo:UBERON_0001981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000055 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004536 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg"^^xsd:anyURI . obo:UBERON_0001474 obo:IAO_0000115 "Skeletal element that is composed of bone tissue." ; obo:RO_0002171 obo:UBERON_0001015, obo:UBERON_0001630, obo:UBERON_0002385 ; obo:UBPROP_0000001 "Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]", "Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]", "Skeletal element that is composed of bone tissue.[VSAO]" ; obo:UBPROP_0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" ; obo:UBPROP_0000003 "The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]" ; oboInOwl:hasDbXref "AAO:0000047", "AEO:0000082", "BTO:0000140", "CALOHA:TS-0088", "EFO:0000298", "EHDAA2:0003082", "EMAPA:32782", "ENVO:00002039", "EV:0100140", "FMA:30317", "FMA:5018", "GAID:92", "MA:0001459", "MAT:0000299", "MIAA:0000299", "NCIT:C12366", "SCTID:90780006", "TAO:0001514", "UMLS:C0262950", "VHOG:0001190", "VSAO:0000057", "Wikipedia:Bone", "XAO:0000169", "ZFA:0001514", "galen:Bone" ; oboInOwl:hasExactSynonym "bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone", "bones" ; oboInOwl:id "UBERON:0001474" ; oboInOwl:inSubset core:efo_slim, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "bone element" ; rdfs:subClassOf obo:UBERON_0004765, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 ], _:genid117090 ; owl:disjointWith obo:UBERON_0001630, obo:UBERON_0005090, obo:UBERON_0010538 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004765 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001476 obo:IAO_0000115 "A muscle of shoulder which attaches to the scapula, clavicle and humerus.[FMA,generalized]." ; obo:UBPROP_0000001 "Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus.[AAO]" ; oboInOwl:hasDbXref "AAO:0010716", "EFO:0001412", "EHDAA2:0000339", "EMAPA:18177", "FMA:32521", "MA:0002286", "NCIT:C32446", "SCTID:181620007", "UMLS:C0224234", "VHOG:0000846", "Wikipedia:Deltoid_muscle" ; oboInOwl:hasExactSynonym "deltoid muscle", "m. deltoideus", "musculus deltoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "common shoulder muscle", "deltoideus", "deltoideus muscle", "musculus deltoideus" ; oboInOwl:id "UBERON:0001476" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "We use a generic definition that includes the deltoideus as represented in AAO: 'Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus'. Kardong: Dorsal group" ; rdfs:label "deltoid" ; rdfs:subClassOf obo:UBERON_0001482, _:genid117111, _:genid117113, _:genid117115, _:genid117117, _:genid117119, _:genid117121, _:genid117123, _:genid117125, _:genid117127, _:genid117129 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Deltoideus.png"^^xsd:anyURI . obo:UBERON_0001479 obo:IAO_0000115 "A sesamoid element that is composed of bone tissue." ; oboInOwl:hasBroadSynonym "sesamoid" ; oboInOwl:hasDbXref "AEO:0000086", "EHDAA2:0003086", "EMAPA:36620", "FMA:32672", "GAID:210", "MA:0001375", "MESH:D012716", "NCIT:C33541", "SCTID:362914002", "UMLS:C0036846", "Wikipedia:Sesamoid_bone", "galen:SessamoidBone" ; oboInOwl:hasExactSynonym "ossa sesamoidea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001479" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage.[VSAO]" ; rdfs:label "sesamoid bone" ; rdfs:subClassOf obo:UBERON_0013630 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013631 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray350.png"^^xsd:anyURI . obo:UBERON_0001480 obo:IAO_0000115 "A carpal bone that proximally_connected_to a forelimb zeugopod skeleton." ; oboInOwl:hasDbXref "EMAPA:36164", "FMA:33302", "MA:0002557", "SCTID:306715004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001480" ; a owl:Class ; rdfs:label "proximal carpal bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015078 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001481 obo:IAO_0000115 "A distal carpal endochondral element that is composed primarily of a bone tissue." ; obo:UBPROP_0000001 "Series of elements that articulate with the metacarpals.[AAO]" ; obo:UBPROP_0000008 "Primitively, each of the distal bones appears to have articulated with a single metacarpal" ; oboInOwl:hasDbXref "AAO:0000847", "EMAPA:36168", "FMA:33303", "MA:0002558", "SCTID:306716003" ; oboInOwl:hasExactSynonym "distal carpal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001481" ; a owl:Class ; rdfs:label "distal carpal bone" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015069 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0002374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015068 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0001482 obo:IAO_0000115 "Any muscle organ that is part of a shoulder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36154", "FMA:33531", "MA:0000633" ; oboInOwl:hasExactSynonym "muscle organ of shoulder", "shoulder muscle", "shoulder muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001482" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle of shoulder" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001467 ], _:genid117172 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003461 ] ) ] . obo:UBERON_0001483 obo:IAO_0000115 "A zone of skin that is part of a shoulder region." ; obo:UBPROP_0000012 "in MA this is a subclass of forelimb skin, but this violates part-disjointness in Uberon" ; oboInOwl:hasDbXref "EMAPA:18059", "FMA:34830", "MA:0000635", "SCTID:244131002" ; oboInOwl:hasExactSynonym "shoulder skin", "shoulder zone of skin", "zone of skin of shoulder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001483" ; a owl:Class ; rdfs:label "skin of shoulder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0001484 obo:IAO_0000115 "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." ; obo:UBPROP_0000012 "check ncita" ; oboInOwl:hasDbXref "EMAPA:37621", "FMA:34836", "GAID:263", "MA:0001519", "MESH:D017746", "NCIT:C32259", "NCIT:C84388", "SCTID:182238002", "UMLS:C0206207", "Wikipedia:Articular_capsule", "galen:JointCapsule" ; oboInOwl:hasExactSynonym "capsula articularis", "fibrous capsule of joint", "joint capsule", "joint fibrous capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "capsulae articulares" ; oboInOwl:id "UBERON:0001484" ; oboInOwl:inSubset core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:label "articular capsule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000094 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0002217 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png"^^xsd:anyURI . obo:UBERON_0001485 obo:IAO_0000115 "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." ; oboInOwl:hasDbXref "EFO:0001957", "EMAPA:19137", "FMA:35175", "GAID:114", "MA:0000471", "MESH:D007719", "NCIT:C32898", "SCTID:182204005", "UMLS:C0022745", "VHOG:0001003", "Wikipedia:Knee", "galen:KneeJoint" ; oboInOwl:hasExactSynonym "joint of knee" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio genus" ; oboInOwl:id "UBERON:0001485" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "knee joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ], _:genid117207 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Knee.agr.jpg"^^xsd:anyURI . obo:UBERON_0001486 obo:IAO_0000115 "A synovial joint that connects the femur to the acetbulum of the innominate bone." ; oboInOwl:hasDbXref "BTO:0001502", "EMAPA:19136", "FMA:35178", "GAID:262", "MA:0000470", "MESH:D006621", "NCIT:C32742", "SCTID:182201002", "UMLS:C0019558", "VHOG:0001001", "Wikipedia:Hip#Articulation", "galen:HipJoint" ; oboInOwl:hasExactSynonym "articulatio coxofemoralis", "femoro-iliac joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coxal articulation" ; oboInOwl:id "UBERON:0001486" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hip joint" ; rdfs:subClassOf obo:UBERON_0011107, _:genid117220, _:genid117222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001269 ] ) ] . obo:UBERON_0001487 obo:IAO_0000115 "A skeletal joint that is part of a pes [Automatically generated definition]." ; obo:IAO_0000116 "TODO check FMA - use the set class for now" ; obo:UBPROP_0000202 obo:FMA_71349 ; oboInOwl:hasDbXref "EMAPA:32949", "FMA:35194", "GAID:256", "MA:0000464", "MESH:D033023", "SCTID:244555001", "Wikipedia:Joints_of_foot" ; oboInOwl:hasExactSynonym "articulationes pedis", "foot joint", "hind limb autopod joint", "joint of pes", "joint of terminal segment of free lower limb", "joints of foot", "pedal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001487" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pes joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0001488 obo:IAO_0000115 "A joint that connects the hindlimb autopod and zeugopod skeletons." ; obo:UBPROP_0000008 "todo - accurately represent different types of ankle joint" ; oboInOwl:hasDbXref "BTO:0004706", "EMAPA:35126", "FMA:35195", "GAID:257", "MA:0000463", "MESH:D000843", "NCIT:C32078", "SCTID:182212002", "UMLS:C0003087", "Wikipedia:Ankle", "galen:AnkleJoint" ; oboInOwl:hasNarrowSynonym "gambrel", "hock", "hock joint", "talotibial joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mortise joint", "talocrural articulation", "talocrural joint" ; oboInOwl:id "UBERON:0001488" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ankle joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001445 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010720 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg"^^xsd:anyURI . obo:UBERON_0001489 obo:IAO_0000115 "A skeletal joint that is part of a manus (hand) [Automatically generated definition]." ; obo:IAO_0000116 "TODO check FMA - use the set class for now" ; obo:UBPROP_0000202 obo:FMA_71345 ; oboInOwl:hasDbXref "EMAPA:32641", "MA:0000452", "SCTID:244546004", "Wikipedia:Joints_of_hand" ; oboInOwl:hasExactSynonym "articulationes manus", "hand joint", "joint of hand", "joint of manus", "joint of terminal segment of free upper limb", "manual joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001489" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manus joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0001490 obo:IAO_0000115 "A joint that connects the forelimb zeugopod and stylopod skeletons[Obol]." ; obo:UBPROP_0000008 "In human anatomy, the elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis" ; oboInOwl:hasDbXref "EMAPA:19102", "FMA:35289", "GAID:253", "MA:0000451", "MESH:D004551", "NCIT:C32497", "SCTID:182169008", "UMLS:C0013770", "VHOG:0000997", "Wikipedia:Elbow", "galen:ElbowJoint" ; oboInOwl:hasExactSynonym "articulatio cubiti", "cubital region joint", "joint of cubital region", "joint of elbow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001490" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "elbow joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ], _:genid117271 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010703 ] ) ] . obo:UBERON_0001491 obo:IAO_0000115 "A joint connecting the forelimb zeugopod skeleton with the carpal skeleton." ; obo:UBPROP_0000012 "in FMA this includes radio-carpal and radio-ulnar *ligaments*" ; oboInOwl:hasDbXref "EMAPA:19205", "FMA:321842", "GAID:274", "MA:0000460", "MESH:D014955", "NCIT:C33894", "SCTID:182178002", "UMLS:C1322271", "Wikipedia:Wrist", "galen:WristJoint" ; oboInOwl:hasExactSynonym "carpal region joint", "joint of carpal region", "joint of wrist" ; oboInOwl:hasNarrowSynonym "radiocarpal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001491" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "wrist joint" ; rdfs:subClassOf obo:UBERON_0001489, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0009880 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010703 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png"^^xsd:anyURI . obo:UBERON_0001492 obo:IAO_0000115 "A nerve that supplies the upper limb, including the triceps brachii muscle of the arm, as well as all 12 muscles in the posterior osteofascial compartment of the forearm, as well as the associated joints and overlying skin." ; oboInOwl:hasDbXref "EHDAA2:0001584", "EHDAA:5650", "EMAPA:17278", "FMA:37069", "GAID:845", "MA:0001171", "MESH:D011826", "NCIT:C52812", "SCTID:181011002", "UMLS:C0034518", "VHOG:0000896", "Wikipedia:Radial_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus radialis" ; oboInOwl:id "UBERON:0001492" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "radial nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001509 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0003403 ], _:genid116949, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001814 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e2/Gray818.png"^^xsd:anyURI . obo:UBERON_0001493 obo:IAO_0000115 "The axillary nerve is a nerve of the human body, that comes off the posterior cord of the brachial plexus at the level of the axilla (armpit) and carries nerve fibers from C5 and C6. The axillary nerve travels through the quadrangular space with the posterior circumflex humeral artery and vein. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:18802", "FMA:37072", "MA:0001166", "NCIT:C52817", "SCTID:181009006", "UMLS:C0228885", "Wikipedia:Axillary_nerve" ; oboInOwl:hasExactSynonym "circumflex humeral nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auxillery nerve", "circumflex nerve", "nervus axillaris" ; oboInOwl:id "UBERON:0001493" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "axillary nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0009472 ], _:genid117301, _:genid117303 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ea/Brachial_plexus_2.svg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/d/d4/Brachial_plexus.jpg"^^xsd:anyURI . obo:UBERON_0001495 obo:IAO_0000115 "Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs." ; obo:UBPROP_0000001 "Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus.[AAO]" ; oboInOwl:hasDbXref "AAO:0010727", "BTO:0000023", "CALOHA:TS-0751", "EMAPA:35670", "FMA:37349", "GAID:153", "MA:0002423", "MESH:D010369", "NCIT:C33286", "SCTID:181621006", "UMLS:C0030747" ; oboInOwl:hasExactSynonym "M. pectoralis", "muscle of pectoral part of chest", "muscle of pectoral region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "breast muscle", "pectoralis", "pectoralis group muscle", "pectoralis muscle" ; oboInOwl:id "UBERON:0001495" ; oboInOwl:inSubset core:grouping_class, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "This currently groups the major and minor muscles (which have different attachment sites) as well as the AAO structure: Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus" ; rdfs:label "pectoral muscle" ; rdfs:subClassOf obo:UBERON_0008196, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010984 ], _:genid117312 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png"^^xsd:anyURI . obo:UBERON_0001496 obo:IAO_0000115 "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." ; oboInOwl:hasDbXref "EHDAA2:0000147", "EHDAA:9828", "EMAPA:17014", "FMA:3736", "MA:0002570", "NCIT:C32150", "SCTID:181299009", "UMLS:C0003956", "Wikipedia:Ascending_aorta" ; oboInOwl:hasExactSynonym "ascending thoracic aorta", "pars ascendens aortae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aorta ascendens", "pars ascendens aortae" ; oboInOwl:id "UBERON:0001496" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ascending aorta" ; rdfs:subClassOf obo:UBERON_0005800, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002061 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005432 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001515 ], _:genid117324 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001497 obo:IAO_0000115 "Any muscle organ that is part of a pelvic girdle [Automatically generated definition]." ; obo:UBPROP_0000012 "Note that in MA, this is a subclass of pelvis muscle; in FMA this is a hindlimb muscle, but recall in FMA hindlimb includes the girdle." ; oboInOwl:hasAlternativeId "UBERON:0003271" ; oboInOwl:hasDbXref "EHDAA:8326", "EMAPA:18184", "EMAPA:18185", "FMA:37367", "MA:0000537", "RETIRED_EHDAA2:0001430" ; oboInOwl:hasExactSynonym "girdle-pelvic muscle organ", "muscle organ of girdle-pelvic", "muscle organ of pelvic girdle", "muscle organ of pelvic girdle bone", "pelvic girdle muscle", "pelvic girdle muscle organ", "pelvic girdle skeletal muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001497" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "muscle of pelvic girdle" ; rdfs:subClassOf _:genid117338 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001271 ] ) ] . obo:UBERON_0001498 obo:IAO_0000115 "Any muscle organ that is part of a pes [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0000477", "EMAPA:36160", "FMA:37369", "MA:0000652", "SCTID:67240005" ; oboInOwl:hasExactSynonym "foot muscle", "foot muscle organ", "muscle of foot", "muscle organ of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001498" ; a owl:Class ; rdfs:label "muscle of pes" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ], _:genid117353 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0001499 obo:IAO_0000115 "A muscle organ that is part of an arm [Automatically generated definition]." ; obo:UBPROP_0000013 "See notes on UBERON:0001460 for possible terminological confusion over term 'arm'. MA uses this consistent with uberon (forelimb muscle is subdivided into shoulder, arm and hand)" ; oboInOwl:hasAlternativeId "UBERON:0003272" ; oboInOwl:hasDbXref "EHDAA:8277", "EMAPA:36053", "MA:0000594", "RETIRED_EHDAA2:0000142" ; oboInOwl:hasExactSynonym "arm muscle", "arm skeletal muscle", "arm skeletal muscle tissue", "muscle of upper arm or lower arm", "upper arm / lower arm muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm muscle system" ; oboInOwl:id "UBERON:0001499" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "muscle of arm" ; rdfs:subClassOf _:genid117363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0001500 obo:IAO_0000115 "Any muscle organ that is part of a manus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32644", "FMA:37372", "MA:0000628", "SCTID:110540008" ; oboInOwl:hasExactSynonym "hand muscle", "manus muscle", "manus muscle organ", "muscle of hand", "muscle organ of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001500" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle of manus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ], _:genid117377 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0001502 obo:IAO_0000115 "Any of the interosseous muscles of the manus (hand). This includes the dorsal and plantar interossei." ; obo:UBPROP_0000001 "The interosseous muscles are flexor muscles of the manus that help support and flex the metacarpophalangeal joints. In some species the muscles are known as the suspensory ligaments. The muscles are found under the deep digital flexor tendon and originate from the base of each metacarpal bone. From its origin each muscle runs a short way down until it divides into two tendons that continue down and insert onto the base of its corresponding proximal phalanx. Each tendon has a sesamoid imbedded within it, that lie over the metacarpophalangeal joint. A small tendon, sometimes known as an extensor branch, continues to proceed from the base of each proximal phalanx and connects to the common extensor tendon. It has a small role to play in the extension of each phalanx. The main innervation of this muscle is via a branch of the ulnaris nerve[MURDOCH:1022]." ; oboInOwl:hasDbXref "EMAPA:36216", "FMA:37417", "MA:0002313", "NCIT:C53173", "SCTID:265804003", "UMLS:C0224295" ; oboInOwl:hasExactSynonym "hand interosseous muscle", "interosseous muscle of hand", "manus interosseous muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001502" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interosseous muscle of manus" ; rdfs:subClassOf obo:UBERON_0014375, _:genid117033, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002234 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006508 _:genid117031 ) ] . obo:UBERON_0001503 obo:IAO_0000115 "The dorsal interossei of the hand are muscles that occupy the space between the metacarpals. There are four dorsal interossei in each hand. They are specified as 'dorsal' to contrast them with the palmar interossei, which are located on the anterior side of the metacarpals. The dorsal interosseous muscles are bipennate, with each muscle arising by two heads from the adjacent sides of the metacarpal bones, but more extensively from the metacarpal bone of the finger into which the muscle is inserted. They are inserted into the bases of the proximal phalanges and into the extensor expansion of the corresponding extensor digitorum tendon. The middle digit has two dorsal interossei insert onto it while the first digit (thumb) and the fifth digit (little finger) have none[WP]." ; oboInOwl:hasDbXref "EMAPA:37519", "FMA:37418", "MA:0002314", "NCIT:C52703", "SCTID:245002007", "UMLS:C1744530", "Wikipedia:Dorsal_interossei_muscles_(hand)" ; oboInOwl:hasExactSynonym "dorsal hand interosseus muscle", "dorsal interosseous of hand", "dorsal manus interosseous muscle", "musculi interossei dorsales manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal interosseous muscle of hand" ; oboInOwl:id "UBERON:0001503" ; a owl:Class ; rdfs:comment "Action: abducts medial digits" ; rdfs:label "dorsal interosseous of manus" ; rdfs:subClassOf obo:UBERON_0001502, _:genid117396, _:genid117398 . obo:UBERON_0001507 obo:IAO_0000115 "A muscle in the forelimb stylopod which in humans has several functions, the most important being to rotate the forearm and to flex the elbow. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "biceps" ; oboInOwl:hasDbXref "BTO:0003419", "EHDAA2:0000167", "EHDAA:8279", "EMAPA:19108", "FMA:37670", "MA:0002269", "NCIT:C32200", "SCTID:265802004", "UMLS:C0559499", "VHOG:0000861", "Wikipedia:Biceps_brachii_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biceps brachii %26 brachialis muscles", "biceps brachii muscle", "biceps cubiti", "biceps muscle", "musculus biceps brachii" ; oboInOwl:id "UBERON:0001507" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "biceps brachii" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ], _:genid117407, _:genid117409, _:genid117411, _:genid117413, _:genid117415 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5d/Biceps_brachii_muscle06.png"^^xsd:anyURI . obo:UBERON_0001508 obo:IAO_0000115 "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." ; obo:IAO_0000232 "Do not confuse with aortic arch" ; obo:UBPROP_0000001 "The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG]" ; obo:UBPROP_0000003 "The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG]" ; obo:UBPROP_0000008 "birds have right aortic arch, mammals left." ; oboInOwl:hasDbXref "BTO:0000157", "EFO:0002526", "EHDAA2:0000132", "EMAPA:17613", "FMA:3768", "GAID:471", "MA:0000475", "SCTID:181300001", "VHOG:0001196", "Wikipedia:Arch_of_aorta" ; oboInOwl:hasExactSynonym "arcus aortae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aortic arch", "thoracic aorta" ; oboInOwl:id "UBERON:0001508" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "arch of aorta" ; rdfs:subClassOf obo:UBERON_0005800, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001496 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005432 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005613 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001515 ], _:genid117427 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001509 obo:IAO_0000115 "The triceps brachii muscle (Latin for 'three-headed' muscle of the arm, it is called a three headed muscle because there are three bundles of muscle, each of different origin, joining together at the elbow) is the large muscle on the back of the human upper limb. It is the muscle principally responsible for extension of the elbow joint (i.e. straightening of the arm). Though a similarly-named muscle, the triceps surae, is found on the lower leg, the triceps brachii is commonly called simply the 'triceps'. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0002080", "EHDAA:8287", "EMAPA:19111", "FMA:37688", "MA:0002399", "NCIT:C33812", "NCIT:C90604", "SCTID:181623009", "UMLS:C0559502", "VHOG:0000851", "Wikipedia:Triceps_brachii_muscle" ; oboInOwl:hasExactSynonym "triceps", "triceps brachii muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus triceps brachii", "triceps muscle" ; oboInOwl:id "UBERON:0001509" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Dorsal group derivative that acts on the forearm[Kardong]" ; rdfs:label "triceps brachii" ; rdfs:subClassOf obo:UBERON_0014892, _:genid117438, _:genid117440, _:genid117442, _:genid117444, _:genid117446, _:genid117448, _:genid117450 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/83/Triceps_brachii.png"^^xsd:anyURI . obo:UBERON_0001510 obo:IAO_0000115 "A zone of skin that is part of a knee [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18151", "FMA:37800", "MA:0000668", "NCIT:C64859", "SCTID:181552001", "UMLS:C0222275" ; oboInOwl:hasExactSynonym "knee skin", "knee zone of skin", "zone of skin of knee" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001510" ; a owl:Class ; rdfs:label "skin of knee" ; rdfs:subClassOf obo:UBERON_0001419, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 _:genid117090 ) ] . obo:UBERON_0001511 obo:IAO_0000115 "A zone of skin that is part of a leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18156", "EMAPA:18159", "EMAPA:37352", "FMA:37828", "MA:0000674", "NCIT:C52749", "UMLS:C0222279" ; oboInOwl:hasExactSynonym "leg skin", "leg zone of skin", "zone of skin of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001511" ; a owl:Class ; rdfs:label "skin of leg" ; rdfs:subClassOf obo:UBERON_0001419 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0001512 obo:IAO_0000115 "A zone of skin that is part of an ankle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37353", "FMA:37831", "MA:0000641", "NCIT:C52751", "SCTID:181560000", "UMLS:C0222286" ; oboInOwl:hasExactSynonym "ankle skin", "ankle zone of skin", "tarsal region skin", "zone of skin of ankle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001512" ; a owl:Class ; rdfs:label "skin of ankle" ; rdfs:subClassOf obo:UBERON_0001419, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] . obo:UBERON_0001513 obo:IAO_0000115 "A zone of skin that is part of a pes [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18504", "FMA:37834", "MA:0000654", "NCIT:C52750", "SCTID:181529000", "UMLS:C0222289" ; oboInOwl:hasExactSynonym "foot skin", "skin of foot" ; oboInOwl:hasNarrowSynonym "skin of hind-paw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001513" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of pes" ; rdfs:subClassOf obo:UBERON_0003532, _:genid117121 ; owl:equivalentClass _:genid117117 . obo:UBERON_0001514 obo:IAO_0000115 "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." ; obo:UBPROP_0000011 "results from fusion of left and right dorsal aortae" ; oboInOwl:hasDbXref "EMAPA:18606", "FMA:3784", "MA:0002571", "NCIT:C32455", "SCTID:261399002", "UMLS:C0011666", "Wikipedia:Descending_aorta" ; oboInOwl:hasExactSynonym "pars descendens aortae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aorta descendens", "pars descendens aortae" ; oboInOwl:id "UBERON:0001514" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "descending aorta" ; rdfs:subClassOf obo:UBERON_0005800, _:genid117127, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ], _:genid117129, [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005622 ], _:genid117498, _:genid117502 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001515 obo:IAO_0000115 "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." ; oboInOwl:hasDbXref "BTO:0000157", "EFO:0002525", "EMAPA:18603", "FMA:3786", "GAID:471", "MA:0002569", "MESH:D001013", "NCIT:C33766", "SCTID:302510009", "UMLS:C1522460", "Wikipedia:Thoracic_aorta", "galen:ThoracicAorta" ; oboInOwl:hasExactSynonym "aorta thoracica", "thoracic part of aorta" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aorta thoracalis", "pars thoracica aortae" ; oboInOwl:id "UBERON:0001515" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "thoracic aorta" ; rdfs:subClassOf obo:UBERON_0005800, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000947 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005800 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png"^^xsd:anyURI . obo:UBERON_0001516 obo:IAO_0000115 "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." ; obo:IAO_0000116 "Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates" ; oboInOwl:hasDbXref "BTO:0002976", "EFO:0002524", "EMAPA:17856", "FMA:3789", "GAID:470", "MA:0000474", "MESH:D001012", "NCIT:C32038", "SCTID:244231007", "UMLS:C0003484", "Wikipedia:Abdominal_aorta", "galen:AbdominalAorta" ; oboInOwl:hasExactSynonym "abdominal part of aorta", "descending abdominal aorta", "pars abdominalis aortae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal part of aorta", "aorta abdominalis", "pars abdominalis aortae" ; oboInOwl:id "UBERON:0001516" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "abdominal aorta" ; rdfs:subClassOf obo:UBERON_0005800, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002345 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001514 ], _:genid117522 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png"^^xsd:anyURI . obo:UBERON_0001517 obo:IAO_0000115 "A zone of skin that is part of a elbow [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003399" ; oboInOwl:hasDbXref "EMAPA:18051", "FMA:38250", "MA:0000610", "NCIT:C52755", "SCTID:181534001", "UMLS:C0222213" ; oboInOwl:hasExactSynonym "cubital region zone of skin", "elbow skin", "elbow zone of skin", "zone of skin of cubital region", "zone of skin of elbow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001517" ; a owl:Class ; rdfs:label "skin of elbow" ; rdfs:subClassOf obo:UBERON_0002427, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] . obo:UBERON_0001518 obo:IAO_0000115 "A zone of skin that is part of a wrist [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37351", "FMA:38280", "MA:0000638", "NCIT:C52752", "SCTID:181540008", "UMLS:C0222223" ; oboInOwl:hasExactSynonym "carpal region zone of skin", "wrist skin", "wrist zone of skin", "zone of skin of carpal region", "zone of skin of wrist" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001518" ; a owl:Class ; rdfs:label "skin of wrist" ; rdfs:subClassOf obo:UBERON_0001419, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] . obo:UBERON_0001519 obo:IAO_0000115 "A zone of skin that is part of a manus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18486", "FMA:38295", "MA:0000630", "NCIT:C52753", "SCTID:181527003", "UMLS:C0222224" ; oboInOwl:hasExactSynonym "hand skin", "manus skin", "skin of hand" ; oboInOwl:hasNarrowSynonym "skin of fore-paw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001519" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of manus" ; rdfs:subClassOf obo:UBERON_0001419 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0001528 obo:IAO_0000115 "A joint that connects the radius and the ulna. Examples: proximal and distal radio-ulnar joints." ; oboInOwl:hasDbXref "EMAPA:19206", "FMA:38863", "MA:0003145", "SCTID:264167003" ; oboInOwl:hasExactSynonym "articulation of the radus and ulna", "radioulnar joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "radioulnar articulation" ; oboInOwl:id "UBERON:0001528" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "radio-ulnar joint" ; rdfs:subClassOf obo:UBERON_0011139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png"^^xsd:anyURI . obo:UBERON_0001529 obo:IAO_0000115 "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." ; oboInOwl:hasBroadSynonym "innominate" ; oboInOwl:hasDbXref "EFO:0002550", "EHDAA2:0000835", "EMAPA:17615", "FMA:3932", "GAID:476", "MA:0001922", "MESH:D016122", "NCIT:C32814", "SCTID:244244002", "UMLS:C0006094", "Wikipedia:Brachiocephalic_artery", "galen:BrachioCephalicArtery" ; oboInOwl:hasExactSynonym "brachiocephalic trunk", "innominate artery", "truncus brachiocephalicus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "truncus brachiocephalicus" ; oboInOwl:id "UBERON:0001529" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "brachiocephalic artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007204 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ], _:genid117207 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001530 obo:IAO_0000115 "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." ; obo:IAO_0000116 "we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery'" ; obo:IAO_0000232 "This class represents the adult and developing structures'" ; obo:UBPROP_0000011 "in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae" ; oboInOwl:hasBroadSynonym "carotid artery" ; oboInOwl:hasDbXref "CALOHA:TS-0116", "EHDAA2:0000217", "EHDAA:7331", "EMAPA:17855", "FMA:3939", "GAID:479", "MA:0001926", "MESH:D017536", "NCIT:C32352", "SCTID:362041005", "UMLS:C0162859", "VHOG:0000272", "Wikipedia:Common_carotid_artery" ; oboInOwl:hasExactSynonym "carotid artery system", "common carotid artery", "trunk of common carotid tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "a. carotis communis" ; oboInOwl:id "UBERON:0001530" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "common carotid artery plus branches" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000068 ], _:genid117590 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001531 obo:IAO_0000115 "The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk." ; obo:UBPROP_0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" ; oboInOwl:hasDbXref "EMAPA:35749", "FMA:3941", "MA:0001928", "NCIT:C33473", "SCTID:362042003", "UMLS:C0226086", "Wikipedia:Right_common_carotid_artery" ; oboInOwl:hasExactSynonym "right common carotid artery", "trunk of right common carotid tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right common carotid artery" ; oboInOwl:id "UBERON:0001531" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "right common carotid artery plus branches" ; rdfs:subClassOf obo:UBERON_0001530, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001529 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001532 obo:IAO_0000115 "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." ; obo:UBPROP_0000001 "Each of two arteries starting at the bifurcation of the common carotid arteries through which blood circulates to many structures and organs in the head. [TFD][VHOG]", "One of the major arteries of the head, it is the as the cranial continuation of the aortic arches and the dorsal aorta. It curves ventrally before resuming a dorsal course as it enters the head proper, and it lies ventral to the internal jugular vein. The internal carotid artery gives off palatine, ophthalmic, and cerebral branches by stage NF stage 41.[AAO]" ; oboInOwl:hasDbXref "AAO:0010219", "AAO:0011054", "BTO:0004697", "EFO:0001952", "EHDAA2:0000873", "EHDAA:408", "EHDAA:6389", "EMAPA:16328", "FMA:3947", "GAID:481", "MA:0001930", "MESH:D002343", "NCIT:C32836", "SCTID:362045001", "TAO:0005081", "UMLS:C0007276", "VHOG:0000267", "Wikipedia:Internal_carotid_artery", "XAO:0000366", "ZFA:0005081" ; oboInOwl:hasExactSynonym "cranial carotid artery", "internal carotid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ICA", "arteria carotis interna" ; oboInOwl:id "UBERON:0001532" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "internal carotid artery" ; rdfs:subClassOf obo:UBERON_0005396, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000970 ], _:genid117611, _:genid117613, _:genid117615 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray513.png"^^xsd:anyURI . obo:UBERON_0001533 obo:IAO_0000115 "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." ; obo:IAO_0000116 "Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO)" ; obo:UBPROP_0000001 "Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO]", "In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP]", "The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO]" ; oboInOwl:hasDbXref "AAO:0010232", "EHDAA2:0001933", "EHDAA:4357", "EMAPA:17617", "FMA:3951", "GAID:511", "MA:0002045", "MESH:D013348", "NCIT:C33643", "SCTID:265790007", "TAO:0005086", "UMLS:C0038530", "Wikipedia:Subclavian_artery", "XAO:0000365", "ZFA:0005086" ; oboInOwl:hasExactSynonym "arteria subclavia", "arterial tree of upper limb", "pectoral artery", "subclavian arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PA", "arteria subclavia" ; oboInOwl:id "UBERON:0001533" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:unverified_taxonomic_grouping, core:vertebrate_core ; a owl:Class ; rdfs:label "subclavian artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000915 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004710 ], _:genid117628, _:genid117630 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001534 obo:IAO_0000115 "The subclavian artery that supplies the right pectoral appendage." ; obo:UBPROP_0000008 "in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery" ; obo:UBPROP_0000011 "proximal part arises from right 4th aortic arch in humans" ; oboInOwl:hasDbXref "EHDAA2:0004514", "EMAPA:37384", "FMA:3953", "MA:0002047", "NCIT:C33490", "SCTID:244246000", "UMLS:C0226261", "Wikipedia:Subclavian_artery" ; oboInOwl:hasExactSynonym "arteria subclavia dextra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001534" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "right subclavian artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001529 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001533 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001535 obo:IAO_0000115 "The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck." ; oboInOwl:hasDbXref "EHDAA2:0002192", "EHDAA:5328", "EMAPA:17314", "FMA:3956", "GAID:518", "MA:0002077", "MESH:D014711", "NCIT:C12819", "SCTID:181323003", "TAO:0005033", "UMLS:C0042559", "VHOG:0000263", "Wikipedia:Vertebral_artery", "ZFA:0005033" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria vertebralis", "vertebral arteries" ; oboInOwl:id "UBERON:0001535" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "The two vertebral arteries and the basilar artery are sometimes together called the vertebrobasilar system, which supplies blood to the posterior part of circle of Willis and anastomoses with blood supplied to the anterior part of the circle of Willis from the carotid arteries. [WP,unvetted]" ; rdfs:label "vertebral artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002240 ], _:genid117271 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/ff/Vertebral_artery.png"^^xsd:anyURI . obo:UBERON_0001536 obo:IAO_0000115 "The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax." ; obo:UBPROP_0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" ; oboInOwl:hasDbXref "EMAPA:35491", "FMA:4058", "MA:0001927", "NCIT:C32956", "SCTID:362043008", "UMLS:C0226087", "Wikipedia:Left_common_carotid_artery" ; oboInOwl:hasExactSynonym "left common carotid artery", "trunk of left common carotid tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "left common carotid artery" ; oboInOwl:id "UBERON:0001536" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "left common carotid artery plus branches" ; rdfs:subClassOf obo:UBERON_0001530, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001543 obo:IAO_0000115 "The lymph nodes which drain the legs; contained in the popliteal fossa." ; obo:UBPROP_0000001 "In the popliteal fossa between biceps femoris m. and semitendinosus m.." ; oboInOwl:hasDbXref "FMA:44227", "MA:0000738", "NCIT:C53146", "SCTID:279156002", "UMLS:C0588057", "Wikipedia:Popliteal_lymph_node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "popliteal glands", "popliteal lymph glands", "popliteal lymph node" ; oboInOwl:id "UBERON:0001543" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "popliteal lymph node" ; rdfs:subClassOf obo:UBERON_0003968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001485 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0016400 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png"^^xsd:anyURI . obo:UBERON_0001544 obo:IAO_0000115 "The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37181", "FMA:44327", "GAID:537", "MA:0002197", "MESH:D011152", "NCIT:C33339", "SCTID:281065001", "UMLS:C0032652", "Wikipedia:Popliteal_vein", "galen:PoplitealVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena poplitea" ; oboInOwl:id "UBERON:0001544" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "popliteal vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001465 ], _:genid117676 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png"^^xsd:anyURI . obo:UBERON_0001545 obo:IAO_0000115 "A vein of the lower limb that carries blood from the anterior compartment of the leg to the popliteal vein which is forms when it joins with the posterior tibial vein. Like most deep veins, the anterior tibial vein is accompanied by an artery of the same name, the anterior tibial artery, along its course. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37135", "FMA:44331", "MA:0002244", "NCIT:C32115", "SCTID:281066000", "UMLS:C0226833", "Wikipedia:Anterior_tibial_vein", "galen:AnteriorTibialVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae tibiales anteriores" ; oboInOwl:id "UBERON:0001545" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "anterior tibial vein" ; rdfs:subClassOf obo:UBERON_0010370, _:genid117683, _:genid117685 ; owl:disjointWith obo:UBERON_0001546 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4e/Gray440_color.png"^^xsd:anyURI . obo:UBERON_0001546 obo:IAO_0000115 "A vein of the lower limb carries blood from the posterior compartment and plantar surface of the foot to the popliteal vein which it forms when it joins with the anterior tibial vein. Like most deep veins, the posterior tibial vein is accompanied by an artery of the same name, the posterior tibial artery, along its course. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37183", "FMA:44332", "MA:0002245", "NCIT:C33386", "SCTID:281067009", "UMLS:C0226832", "Wikipedia:Posterior_tibial_vein", "galen:PosteriorTibialVein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae tibiales posteriores" ; oboInOwl:id "UBERON:0001546" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "posterior tibial vein" ; rdfs:subClassOf obo:UBERON_0010370, _:genid117693, _:genid117695 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray583.png"^^xsd:anyURI . obo:UBERON_0001547 obo:IAO_0000115 "The small saphenous vein (also lesser saphenous vein), is a relatively large vein of the superficial posterior leg. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0003272", "EMAPA:37187", "FMA:44333", "MA:0002217", "NCIT:C33546", "SCTID:181404009", "UMLS:C0226827", "Wikipedia:Small_saphenous_vein", "galen:LesserSaphenousVein" ; oboInOwl:hasExactSynonym "lesser saphenous vein", "short saphenous vein", "vena saphena parva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001547" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "small saphenous vein" ; rdfs:subClassOf obo:UBERON_0007318, _:genid117701 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/62/Gray582.png"^^xsd:anyURI . obo:UBERON_0001549 obo:IAO_0000115 "The dorsal metatarsal veins are veins which drain the metatarsus of the foot. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37143", "FMA:44377", "MA:0002105", "NCIT:C52689", "UMLS:C0835053", "Wikipedia:Dorsal_metatarsal_veins" ; oboInOwl:hasExactSynonym "metatarsal vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae metatarsales dorsales" ; oboInOwl:id "UBERON:0001549" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "dorsal metatarsal vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0008783 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 _:genid117324 ) ] . obo:UBERON_0001550 obo:IAO_0000115 "A continuation of the Dorsal venous arch of the foot and is the origin of the long saphenous vein." ; oboInOwl:hasDbXref "EMAPA:37170", "FMA:44420", "MA:0002171", "Wikipedia:Medial_marginal_vein" ; oboInOwl:hasExactSynonym "medial marginal vein of foot", "vena marginalis medialis", "vena marginalis medialis pedis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001550" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medial marginal vein" ; rdfs:subClassOf obo:UBERON_0001638, _:genid117716 . obo:UBERON_0001551 obo:UBPROP_0000013 "The term 'sural veins' is not sufficient to appropriately designate the complex venous system of the calf. This should be designated as soleal veins (venae solealis), the veins of the soleus muscle and gastrocnemius veins (venae gastrocnemii)" ; oboInOwl:hasDbXref "EMAPA:37231", "FMA:44561", "MA:0002231" ; oboInOwl:hasExactSynonym "sural vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001551" ; a owl:Class ; rdfs:label "vein of hindlimb zeugopod" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001665 ], _:genid117723 . obo:UBERON_0001552 obo:IAO_0000115 "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." ; oboInOwl:hasBroadSynonym "arcuate artery" ; oboInOwl:hasDbXref "EMAPA:28215", "FMA:70497", "MA:0002583", "Wikipedia:Arcuate_arteries_of_the_kidney" ; oboInOwl:hasExactSynonym "renal arcuate artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001552" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "kidney arcuate artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0009885 ], _:genid117728 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg"^^xsd:anyURI . obo:UBERON_0001554 obo:IAO_0000115 "A zone of skin that is part of a hip region." ; obo:UBPROP_0000012 "in MA this isa hindlimb skin" ; oboInOwl:hasDbXref "EMAPA:18148", "FMA:45282", "MA:0000658", "SCTID:181518004" ; oboInOwl:hasExactSynonym "hip region zone of skin", "hip skin", "hip zone of skin", "regio coxae zone of skin", "zone of skin of hip", "zone of skin of hip region", "zone of skin of regio coxae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001554" ; a owl:Class ; rdfs:label "skin of hip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] . obo:UBERON_0001555 obo:IAO_0000115 "A tube extending from the mouth to the anus." ; obo:RO_0002161 obo:NCBITaxon_147099, obo:NCBITaxon_41324 ; obo:UBPROP_0000001 "The alimentary or digestive tract, and associated organs.[TAO]" ; obo:UBPROP_0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "FMA also has a term 'gastrointestinal tract', but this includes the liver.", "we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509" ; obo:UBPROP_0000013 "we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this" ; oboInOwl:hasBroadSynonym "gut" ; oboInOwl:hasDbXref "AAO:0010023", "BILA:0000083", "BTO:0000511", "BTO:0000545", "EHDAA2:0000726", "EHDAA:518", "EMAPA:16247", "FBbt:00003125", "FMA:45615", "MA:0000917", "NCIT:C34082", "TAO:0000112", "TGMA:0001819", "UMLS:C0017189", "VHOG:0000309", "WBbt:0005743", "ZFA:0000112", "galen:AlimentaryTract" ; oboInOwl:hasExactSynonym "digestive tube", "enteric tract" ; oboInOwl:hasNarrowSynonym "alimentary canal", "alimentary tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digestive canal", "gut tube" ; oboInOwl:id "UBERON:0001555" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "digestive tract" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000165 ], _:genid117748 . obo:UBERON_0001556 obo:IAO_0000115 "Subdivision of urinary system which consists of the urinary bladder and the urethra." ; oboInOwl:hasDbXref "FMA:45659", "MA:0002636", "SCTID:181420004", "galen:LowerUrinaryTract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001556" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lower urinary tract" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000057 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001255 ] . obo:UBERON_0001557 obo:IAO_0000115 "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." ; obo:RO_0002171 obo:UBERON_0001558 ; obo:UBPROP_0000012 "Some specify that the glottis (vocal cords) is the defining line between the upper and lower respiratory tracts;[2] yet even others make the line at the cricoid cartilage. The FMA includes nose, nasopharynx, oropharynx and larynx[WP]" ; oboInOwl:hasDbXref "EHDAA2:0002136", "EMAPA:17669", "FMA:45661", "MA:0000442", "SCTID:361381009", "VHOG:0000406", "Wikipedia:Upper_respiratory_tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001557" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "upper respiratory tract" ; rdfs:subClassOf obo:UBERON_0000072, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000004 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg"^^xsd:anyURI . obo:UBERON_0001558 obo:IAO_0000115 "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." ; oboInOwl:hasDbXref "EHDAA2:0001036", "EMAPA:16738", "FMA:45662", "MA:0000435", "SCTID:281488008", "VHOG:0000382", "Wikipedia:Lower_respiratory_tract" ; oboInOwl:hasExactSynonym "lower respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001558" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lower respiratory tract" ; rdfs:subClassOf obo:UBERON_0000072, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000170 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg"^^xsd:anyURI . obo:UBERON_0001560 oboInOwl:hasDbXref "FMA:45733" ; oboInOwl:hasExactSynonym "organ neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001560" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "neck of organ" ; rdfs:subClassOf obo:UBERON_0034944 . obo:UBERON_0001562 obo:IAO_0000115 "A group of muscles (or in some classifications, muscle bellies) that are located under the jaw and attach to the base of the cranium and typically attaches to the hyoid apparatus via a common tendon." ; obo:IAO_0000232 "this class refers to the mereological sum of digastric muscles in an organism (typically two)." ; obo:UBPROP_0000001 "The digastric muscle (also digastricus) (named digastric as it has two bellies) is a small muscle located under the jaw. It lies below the body of the mandible, and extends, in a curved form, from the mastoid process to the symphysis menti. It belongs to the suprahyoid muscles group. A broad aponeurotic layer is given off from the tendon of the digastricus on either side, to be attached to body and greater cornu of the hyoid bone; this is termed the suprahyoid aponeurosis. Wikipedia:Digastric_muscle]." ; obo:UBPROP_0000008 "In most mammals there is a common tendon between the ant. and post. muscles, which also makes a connection to the hyoid apparatus, and then the other attachment is to the base of the cranium" ; oboInOwl:hasDbXref "EMAPA:25134", "FMA:46291", "MA:0002288", "NCIT:C32462", "SCTID:244825002", "UMLS:C0224155", "Wikipedia:Digastric_muscle" ; oboInOwl:hasExactSynonym "digastric", "musculus digastricus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digastric", "digastric muscle", "digastricus", "musculus digastricus" ; oboInOwl:id "UBERON:0001562" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "digastric muscle group" ; rdfs:subClassOf obo:UBERON_0008571, _:genid117771, _:genid117773 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/26/Digastricus.png"^^xsd:anyURI . obo:UBERON_0001564 obo:IAO_0000115 "The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking right and left mylohyoid and the mandible." ; obo:UBPROP_0000001 "The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking R and L mylohyoid and the mandible.[FEED]" ; oboInOwl:hasDbXref "EMAPA:25136", "FMA:46320", "MA:0002344", "MFMO:0000084", "NCIT:C52962", "SCTID:244827005", "UMLS:C0224159", "Wikipedia:Mylohyoid_muscle" ; oboInOwl:hasExactSynonym "musculus mylohyoideus", "mylohyoid", "mylohyoideus", "mylohyoideus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus mylohyoideus" ; oboInOwl:id "UBERON:0001564" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "Taxon motes: mylohyoideus and digastricus anterior of rats derived from intermandibularis posterior, see e.g. Jarvik [53] http://www.biomedcentral.com/1471-213X/8/24/table/T3" ; rdfs:label "mylohyoid muscle" ; rdfs:subClassOf obo:UBERON_0008571, _:genid117786, _:genid117788, _:genid117790 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/92/Mylohyoid_muscle.PNG"^^xsd:anyURI . obo:UBERON_0001565 obo:IAO_0000115 "The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by the first cervical nerve (C1)." ; obo:UBPROP_0000001 "The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by C1.[FEED]" ; obo:UBPROP_0000014 "draws hyoid cranially" ; oboInOwl:hasDbXref "EMAPA:36626", "FMA:46325", "MA:0002308", "NCIT:C52930", "SCTID:244828000", "UMLS:C0224160", "Wikipedia:Geniohyoid_muscle" ; oboInOwl:hasExactSynonym "genio-hyoideus", "genio-hyoideus muscle", "geniohyoid", "geniohyoideus", "geniohyoideus muscle", "m. geniohyoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus geniohyoideus" ; oboInOwl:id "UBERON:0001565" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "geniohyoid muscle" ; rdfs:subClassOf obo:UBERON_0008571, obo:UBERON_0011151, _:genid117801, _:genid117803, _:genid117805, _:genid117807 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2c/Geniohyoid_muscle.PNG"^^xsd:anyURI . obo:UBERON_0001566 obo:IAO_0000115 "Intrinsic muscle of the larynx, innervated by the external division of the laryngeal nerve, a branch of the vagus nerve. It attaches to the anterolateral surface of the cricoid cartilage and the external surface of the thyroid cartilage." ; oboInOwl:hasDbXref "EMAPA:19270", "FMA:46417", "MA:0002284", "MFMO:0000324", "NCIT:C32404", "SCTID:244809007", "UMLS:C0224178", "Wikipedia:Cricothyroid_muscle" ; oboInOwl:hasExactSynonym "M. cricothyroideus", "cricothyroid", "cricothyroideus", "musculus cricothyroideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001566" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "cricothyroid muscle" ; rdfs:subClassOf obo:UBERON_0006328, _:genid117824, _:genid117826, _:genid117828 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001759 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Musculuscricothyreoideus.png"^^xsd:anyURI . obo:UBERON_0001567 obo:IAO_0000115 "A fleshy subdivision of one side of the face bounded by an eye, ear and the nose." ; obo:UBPROP_0000001 "Surface structure that includes the scales, skin, and muscles that are located ventral and posterior to the eye.[TAO]" ; obo:UBPROP_0000007 "buccal" ; obo:UBPROP_0000008 "In many animals the inside of the cheek is lined with mucous membrane covered with stratified squamous epithelium and supplied with secretions from buccal glands." ; oboInOwl:hasDbXref "BTO:0001754", "EMAPA:37451", "FMA:46476", "GAID:65", "MA:0002475", "MESH:D002610", "NCIT:C13070", "SCTID:182325008", "TAO:0002113", "UMLS:C0007966", "Wikipedia:Cheek", "galen:Cheek" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "buccae", "jowl" ; oboInOwl:id "UBERON:0001567" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cheek" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004089 ], _:genid117836 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a9/Chica_cachetona.jpg"^^xsd:anyURI . obo:UBERON_0001568 obo:IAO_0000115 "The muscles associated with the larynx." ; oboInOwl:hasDbXref "BTO:0001626", "EMAPA:35473", "FMA:46562", "GAID:144", "MA:0001768", "MESH:D007821", "NCIT:C32934", "SCTID:181744001", "UMLS:C0023054", "Wikipedia:Muscles_of_larynx" ; oboInOwl:hasExactSynonym "laryngeal muscle", "larynx muscle", "larynx muscle organ", "muscle organ of larynx", "musculi laryngeales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001568" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "muscle of larynx" ; rdfs:subClassOf obo:UBERON_0002377, _:genid117446, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001015 ], _:genid117448, _:genid117849 ; owl:equivalentClass _:genid117442 . obo:UBERON_0001571 obo:IAO_0000115 "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue." ; obo:UBPROP_0000001 "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue. [TFD][VHOG]", "Makes up bulk of tongue in frogs and salamanders; makes up entire tongue in caecilians.[AAO]", "see Intrinsic Tongue.[FEED]" ; obo:UBPROP_0000002 "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" ; obo:UBPROP_0000003 "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" ; obo:UBPROP_0000008 "Makes up bulk of tongue in frogs and salamanders; makes up entire tongue in caecilians." ; oboInOwl:hasDbXref "AAO:0010660", "EHDAA2:0000704", "EHDAA:9150", "EMAPA:18276", "FMA:46690", "MA:0002307", "NCIT:C52928", "SCTID:244784007", "UMLS:C0224194", "VHOG:0000847", "Wikipedia:Genioglossus_muscle" ; oboInOwl:hasExactSynonym "genioglossus", "m. genioglossus", "musculus genioglossus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001571" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "genioglossus muscle" ; rdfs:subClassOf obo:UBERON_0001575, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006606 ], _:genid117858, _:genid117860, _:genid117863 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Genioglossus.png"^^xsd:anyURI . obo:UBERON_0001572 obo:IAO_0000115 "A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII." ; obo:UBPROP_0000001 "Makes up part of the tongue in frogs and salamanders.[AAO]", "The hyoglossus is a muscle that attaches to the hyoid and tongue and is innervated by Cranial Nerve XII.[FEED]" ; obo:UBPROP_0000002 "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" ; oboInOwl:hasDbXref "AAO:0010663", "EMAPA:18277", "FMA:46691", "MA:0002317", "MFMO:0000064", "NCIT:C53161", "SCTID:244785008", "UMLS:C0224196", "Wikipedia:Hyoglossus_muscle" ; oboInOwl:hasExactSynonym "hyoglossus", "m. hyoglossus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001572" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "hyoglossus muscle" ; rdfs:subClassOf obo:UBERON_0001575, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001723 ], _:genid117882 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001685 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Hyoglossus.png"^^xsd:anyURI . obo:UBERON_0001573 obo:IAO_0000115 "The Styloglossus, the shortest and smallest of the three styloid muscles, arises from the anterior and lateral surfaces of the styloid process, near its apex, and from the stylomandibular ligament. Passing downward and forward between the internal and external carotid arteries, it divides upon the side of the tongue near its dorsal surface, blending with the fibers of the Longitudinalis inferior in front of the Hyoglossus; the other, oblique, overlaps the Hyoglossus and decussates with its fibers. [WP,unvetted]." ; obo:UBPROP_0000001 "Styloglossus is a muscle that attaches to the tongue and stylohyal and is innervated by Cranial Nerve XII.[FEED]" ; oboInOwl:hasDbXref "EMAPA:18279", "FMA:46692", "MA:0002387", "NCIT:C53071", "UMLS:C0224195", "Wikipedia:Styloglossus" ; oboInOwl:hasExactSynonym "syloglossus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus styloglossus" ; oboInOwl:id "UBERON:0001573" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "styloglossus" ; rdfs:subClassOf obo:UBERON_0001575, _:genid117892, _:genid117894, _:genid117896 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Styloglossus.png"^^xsd:anyURI . obo:UBERON_0001574 obo:IAO_0000115 "The palatoglossus, glossopalatinus, or palatoglossal muscle is a small fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the glossopalatine arch. It arises from the anterior surface of the soft palate, where it is continuous with the muscle of the opposite side, and passing downward, forward, and lateralward in front of the palatine tonsil, is inserted into the side of the tongue, some of its fibers spreading over the dorsum, and others passing deeply into the substance of the organ to intermingle with the Transversus linguæ. [WP,unvetted]." ; obo:UBPROP_0000001 "Palatoglossus is a muscle that attaches to the soft palate and the tongue and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" ; oboInOwl:hasDbXref "EMAPA:18278", "FMA:46697", "MA:0002351", "NCIT:C53170", "SCTID:244783001", "UMLS:C1704249", "Wikipedia:Palatoglossus_muscle" ; oboInOwl:hasExactSynonym "palatoglossal", "palatoglossal muscle", "palatoglossus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus palatoglossus" ; oboInOwl:id "UBERON:0001574" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "palatoglossus muscle" ; rdfs:subClassOf obo:UBERON_0003682, _:genid117902, _:genid117904, _:genid117906 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Gray1014.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray1028.png"^^xsd:anyURI . obo:UBERON_0001575 obo:IAO_0000115 "A muscle organ that attaches the tongue to some other structure." ; obo:UBPROP_0000003 "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" ; obo:UBPROP_0000009 "main functions are altering the tongue's position allowing for protrusion, retraction, and side-to-side movement" ; obo:UBPROP_0000010 "All intrinsic and extrinsic muscles of the tongue are supplied by the hypoglossal nerve (CN XII), except for one of the extrinsic muscles, palatoglossus, which is innervated by the Vagus nerve CN X of the pharyngeal plexus." ; oboInOwl:hasDbXref "EHDAA2:0002063", "EHDAA:9148", "EMAPA:18275", "FMA:46699", "MA:0002296", "SCTID:244782006", "VHOG:0000825" ; oboInOwl:hasExactSynonym "extrinsic lingual muscle", "extrinsic tongue muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001575" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "extrinsic muscle of tongue" ; rdfs:subClassOf obo:UBERON_0000378, [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0011332 ], _:genid117921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002177 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004765 ] ) ] . obo:UBERON_0001576 obo:IAO_0000115 "The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII." ; obo:UBPROP_0000001 "The intrinsic tongue muscles are an integral part of the tongue that are innervated by Cranial Nerve XII.[FEED]" ; obo:UBPROP_0000003 "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" ; obo:UBPROP_0000009 "The main function of the intrinsic muscles is to provide shape. They are not involved with changing the position of the tongue and are not attached to bone" ; oboInOwl:hasDbXref "EHDAA2:0002064", "EHDAA:9152", "EMAPA:18280", "FMA:46701", "MA:0002327", "SCTID:244788005", "VHOG:0000748" ; oboInOwl:hasExactSynonym "intrinsic lingual muscle", "intrinsic tongue muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001576" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "intrinsic muscle of tongue" ; rdfs:subClassOf obo:UBERON_0000378, _:genid117937, _:genid117939 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002177 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0001577 obo:IAO_0000115 "A muscle innervated by a facial nerve." ; oboInOwl:hasDbXref "FMA:46751", "GAID:143", "MA:0003160", "MESH:D005152", "MFMO:0000005", "NCIT:C13073", "SCTID:25903009", "UMLS:C0015460", "Wikipedia:Facial_muscles", "XAO:0001013" ; oboInOwl:hasExactSynonym "face muscle", "face muscle organ", "facial muscle", "facial muscle proper", "facial nerve innervated muscle", "facial nerve muscle", "muscle of face", "muscle organ of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial-facial muscle", "cranio-facial muscle", "craniofacial muscle", "mimetic muscles", "muscle of facil expression", "muscles of facial expression", "musculi faciei" ; oboInOwl:id "UBERON:0001577" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "facial muscle" ; rdfs:subClassOf obo:UBERON_0015789, _:genid117949 ; owl:disjointWith obo:UBERON_0003681 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png"^^xsd:anyURI . obo:UBERON_0001578 obo:IAO_0000115 "A circumorbital muscle in the face that closes the eyelid[HP]." ; oboInOwl:hasDbXref "EMAPA:35619", "FMA:46779", "MA:0001254", "NCIT:C52886", "SCTID:244726006", "UMLS:C0224122", "Wikipedia:Orbicularis_oculi_muscle" ; oboInOwl:hasExactSynonym "orbicularis oculi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus orbicularis oculi", "tensor tarsi" ; oboInOwl:id "UBERON:0001578" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "It arises from the nasal part of the frontal bone, from the frontal process of the maxilla in front of the lacrimal groove, and from the anterior surface and borders of a short fibrous band, the medial palpebral ligament. From this origin, the fibers are directed lateralward, forming a broad and thin layer, which occupies the eyelids or palpebræ, surrounds the circumference of the orbit, and spreads over the temple, and downward on the cheek. The palpebral portion of the muscle is thin and pale; it arises from the bifurcation of the medial palpebral ligament, forms a series of concentric curves, and is inserted into the lateral palpebral raphé. The orbital portion is thicker and of a reddish color; its fibers form a complete ellipse without interruption at the lateral palpebral commissure; the upper fibers of this portion blend with the Frontalis and Corrugator. The lacrimal part (Tensor tarsi) is a small, thin muscle, about 6 mm. in breadth and 12 mm. in length, situated behind the medial palpebral ligament and lacrimal sac. It arises from the posterior crest and adjacent part of the orbital surface of the lacrimal bone, and passing behind the lacrimal sac, divides into two slips, upper and lower, which are inserted into the superior and inferior tarsi medial to the puncta lacrimalia; occasionally it is very indistinct. [WP,unvetted]. [Wikipedia:Orbicularis_oculi_muscle]" ; rdfs:label "orbicularis oculi muscle" ; rdfs:subClassOf obo:UBERON_0003660, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0004772 ], _:genid117967, _:genid117969, _:genid117971, _:genid117973, _:genid117975 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e2/Gray379.png"^^xsd:anyURI . obo:UBERON_0001580 obo:IAO_0000115 "The levator labii superioris (or quadratus labii superioris) is a broad sheet, the origin of which extends from the side of the nose to the zygomatic bone. Its medial fibers form the angular head, which arises by a pointed extremity from the upper part of the frontal process of the maxilla and passing obliquely downward and lateralward divides into two slips. One of these is inserted into the greater alar cartilage and skin of the nose; the other is prolonged into the lateral part of the upper lip, blending with the infraorbital head and with the Orbicularis oris. The intermediate portion or infraorbital head arises from the lower margin of the orbit immediately above the infraorbital foramen, some of its fibers being attached to the maxilla, others to the zygomatic bone. Its fibers converge, to be inserted into the muscular substance of the upper lip between the angular head and the Caninus. The lateral fibers, forming the zygomatic head, arise from the malar surface of the zygomatic bone immediately behind the zygomaticomaxillary suture and pass downward and medialward to the upper lip. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37503", "FMA:46805", "MA:0002333", "MFMO:0000136", "NCIT:C53164", "UMLS:C1704248", "Wikipedia:Levator_labii_superioris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus levator labii superioris" ; oboInOwl:id "UBERON:0001580" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "levator labii superioris" ; rdfs:subClassOf obo:UBERON_0001577, _:genid117984, _:genid117986, _:genid117988 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8f/Levator_labii_superioris.png"^^xsd:anyURI . obo:UBERON_0001581 obo:IAO_0000115 "A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip, orbicularis oris muscle, and mandible, and superficial and lateral to the mentalis muscle. See Diogo et al., 2009; Burrows et al., 2011)." ; oboInOwl:hasDbXref "EMAPA:37516", "FMA:46816", "MA:0002287", "MFMO:0000123", "NCIT:C53152", "UMLS:C0224119", "Wikipedia:Depressor_labii_inferioris_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001581" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "depressor labii inferioris" ; rdfs:subClassOf obo:UBERON_0001577, _:genid117995, _:genid117997, _:genid117999, _:genid118001, _:genid118003 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Depressor_labii_inferioris.png"^^xsd:anyURI . obo:UBERON_0001582 obo:IAO_0000115 "The buccinator is a muscle that is attached to the mandible, skin, pterygomandibular raphe and maxilla, and is innervated by Cranial Nerve VII and participates in oropharyngeal behavior." ; obo:IAO_0000116 "logical definition provided by FEED" ; oboInOwl:hasDbXref "EMAPA:37453", "FMA:46834", "MA:0002272", "MFMO:0000002", "NCIT:C53150", "SCTID:244747005", "UMLS:C0224121", "Wikipedia:Buccinator_muscle" ; oboInOwl:hasExactSynonym "buccinator", "musculus buccinator" ; oboInOwl:hasNarrowSynonym "trumpeters muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "buccinatorius", "musculus buccinator" ; oboInOwl:id "UBERON:0001582" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "buccinator muscle" ; rdfs:subClassOf _:genid118020, _:genid118022, _:genid118024 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011349 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011386 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Buccinator.jpg"^^xsd:anyURI . obo:UBERON_0001584 obo:IAO_0000115 "The subclavian artery that supplies the left pectoral appendage." ; obo:UBPROP_0000008 "in humans, branches off the arch of aorta" ; obo:UBPROP_0000011 "arises from left intersegmental 6th artery in the region of the 6th -7th cervical segment in humans" ; oboInOwl:hasDbXref "EMAPA:37100", "FMA:4694", "MA:0002046", "NCIT:C32972", "SCTID:244245001", "UMLS:C0226262", "Wikipedia:Subclavian_artery" ; oboInOwl:hasExactSynonym "arteria subclavia (sinistra)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001584" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "left subclavian artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001508 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001508 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001533 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg"^^xsd:anyURI . obo:UBERON_0001585 obo:IAO_0000115 "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." ; obo:UBPROP_0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" ; obo:UBPROP_0000008 "The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green)." ; oboInOwl:hasDbXref "BTO:0002683", "EHDAA2:0001962", "EHDAA:8726", "EMAPA:18417", "FMA:4720", "GAID:549", "MA:0000481", "MESH:D014683", "NCIT:C12816", "SCTID:181368006", "UMLS:C0042459", "VHOG:0001195", "Wikipedia:Superior_vena_cava", "galen:SuperiorVenaCava" ; oboInOwl:hasExactSynonym "superior caval vein", "superior vena cava" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial vena cava", "precava", "vena cava superior", "vena maxima" ; oboInOwl:id "UBERON:0001585" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "anterior vena cava" ; rdfs:subClassOf _:genid117613 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004087 _:genid117611 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png"^^xsd:anyURI . obo:UBERON_0001586 obo:IAO_0000115 "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." ; obo:UBPROP_0000001 "Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO]" ; oboInOwl:hasDbXref "AAO:0010236", "EHDAA2:0000877", "EHDAA:5407", "EMAPA:17620", "FMA:4724", "MA:0002157", "NCIT:C32849", "RETIRED_EHDAA2:0000878", "SCTID:181372005", "UMLS:C0226550", "Wikipedia:Internal_jugular_vein", "XAO:0000382", "galen:InternalJugularVein" ; oboInOwl:hasExactSynonym "internal jugular", "internal jugular venous tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena jugularis interna" ; oboInOwl:id "UBERON:0001586" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "internal jugular vein" ; rdfs:subClassOf obo:UBERON_0004711, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0003711 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001456 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png"^^xsd:anyURI . obo:UBERON_0001587 obo:IAO_0000115 "The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger." ; obo:UBPROP_0000001 "Vein which collects blood from the forelimb via the brachial veins and from the muscles and skin of the trunk via the anterior epigastric and lateral veins.[AAO]" ; oboInOwl:hasDbXref "AAO:0010510", "EHDAA2:0001934", "EHDAA:4455", "EMAPA:17621", "FMA:4725", "GAID:546", "MA:0002221", "MESH:D013350", "NCIT:C12794", "SCTID:181388005", "UMLS:C0038532", "Wikipedia:Subclavian_vein", "galen:SubclavianVein" ; oboInOwl:hasExactSynonym "subclavian venous tree", "vena subclavia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001587" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "subclavian vein" ; rdfs:subClassOf obo:UBERON_0001638, _:genid117630, [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0004710 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png"^^xsd:anyURI . obo:UBERON_0001591 obo:IAO_0000115 "A vein that drains blood from the thymus." ; oboInOwl:hasDbXref "EMAPA:36325", "FMA:4747", "MA:0002246", "NCIT:C53143", "SCTID:303432009", "UMLS:C0226698", "Wikipedia:Thymic_veins" ; oboInOwl:hasExactSynonym "thymic tributary of brachiocephalic vein", "vena thymica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae thymicae" ; oboInOwl:id "UBERON:0001591" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thymic vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0003711 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0001592 obo:IAO_0000115 "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:36284", "FMA:4749", "MA:0002088", "NCIT:C53031", "SCTID:198293000", "UMLS:C0226650", "Wikipedia:Bronchial_veins" ; oboInOwl:hasExactSynonym "bronchial venous tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001592" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "bronchial vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0001593 obo:IAO_0000115 "A congregation of multiple veins." ; oboInOwl:hasDbXref "EMAPA:36327", "FMA:4767", "MA:0000069", "SCTID:322151008", "Wikipedia:Venous_plexus" ; oboInOwl:hasExactSynonym "venous network" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus venosus", "rete venosum" ; oboInOwl:id "UBERON:0001593" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "venous plexus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005629 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png"^^xsd:anyURI . obo:UBERON_0001597 obo:IAO_0000115 "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch." ; obo:UBPROP_0000003 "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" ; obo:UBPROP_0000008 "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati)", "The masseter is a jaw muscle of therapsids derived from the m. adductor mandibulae externus, which originates in the adductor chamber (in the temporal fenestra) and inserts on the coronoid process and internal surface of the lower jaw.[Palaeos]" ; oboInOwl:hasDbXref "BTO:0001755", "EFO:0001424", "EHDAA2:0001067", "EHDAA:10561", "EMAPA:25135", "FMA:48996", "MA:0002343", "MESH:D008406", "MFMO:0000075", "NCIT:C13074", "SCTID:181738000", "UMLS:C0024876", "VHOG:0000823", "Wikipedia:Masseter_muscle" ; oboInOwl:hasExactSynonym "masseter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus masseter" ; oboInOwl:id "UBERON:0001597" ; oboInOwl:inSubset core:efo_slim, core:feed_aligned, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "masseter muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/540"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0003681, [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0011321 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071626 ], _:genid118099, _:genid118103, _:genid118105, _:genid118107 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018544 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002500 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011344 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/78/Illu_head_neck_muscle.jpg"^^xsd:anyURI . obo:UBERON_0001598 obo:IAO_0000115 "Pharyngeal arch 1 muscle that is innervated by the deep temporal branches of the trigeminal nerve and attaches to the wall of the braincase (including the cranial vault) and mandible." ; obo:UBPROP_0000001 "Pharyngeal arch 1 muscle that is innervated by the deep temporal nerves and attaches to the wall of the braincase and mandible.[FEED]", "the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible" ; obo:UBPROP_0000003 "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "jaw adductor muscle" ; oboInOwl:hasDbXref "EHDAA2:0002001", "EHDAA:10565", "EMAPA:25138", "FMA:49006", "GAID:148", "MA:0002390", "MESH:D013703", "NCIT:C33743", "SCTID:181739008", "UMLS:C0039487", "VHOG:0000929", "Wikipedia:Temporal_muscle" ; oboInOwl:hasExactSynonym "musculus temporalis", "temporal muscle", "temporalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus temporalis" ; oboInOwl:id "UBERON:0001598" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "temporalis muscle" ; rdfs:subClassOf obo:UBERON_0003681, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071626 ], _:genid118116, _:genid118119, _:genid118121 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d3/Gray382.png"^^xsd:anyURI . obo:UBERON_0001599 obo:IAO_0000115 "The muscle that stabilizes the stapes bone. The stapedius emerges from a pinpoint foramen in the apex of the pyramidal eminence (a hollow, cone-shaped prominence in the posterior wall of the tympanic cavity), and inserts into the neck of the stapes. [WP,unvetted]." ; obo:UBPROP_0000003 "The depressor mandibulae of tetrapods, which opens the jaws, is the homologue of the levator operculi and epihyoidean. In mammals, the depressor mandibulae evolves into the stapedius (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA:9029", "EMAPA:18586", "FMA:49027", "GAID:164", "MA:0001220", "MESH:D013198", "NCIT:C33611", "SCTID:244780003", "UMLS:C0038151", "VHOG:0000813", "Wikipedia:Stapedius_muscle" ; oboInOwl:hasExactSynonym "stapedius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus stapedius" ; oboInOwl:id "UBERON:0001599" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "stapedius muscle" ; rdfs:subClassOf _:genid117695, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010929 ], _:genid118136, _:genid118139 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004113 _:genid117693 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Musculusstapedius.png"^^xsd:anyURI . obo:UBERON_0001600 obo:IAO_0000115 "The larger of the two muscles of the tympanic cavity, is contained in the bony canal above the osseous portion of the auditory tube. Its role is to dampen sounds produced from chewing. It arises from the cartilaginous portion of the auditory tube and the adjoining part of the great wing of the sphenoid, as well as from the osseous canal in which it is contained. Passing backward through the canal, it ends in a slender tendon which enters the tympanic cavity, makes a sharp bend around the extremity of the septum, known as the processus cochleariformis[1], and is inserted into the manubrium of the malleus, near its root[WP]." ; obo:UBPROP_0000003 "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0005238" ; oboInOwl:hasDbXref "EHDAA2:0002002", "EHDAA:10167", "EHDAA:10191", "EMAPA:18587", "FMA:49028", "GAID:166", "MA:0001221", "MESH:D013719", "NCIT:C33748", "SCTID:244779001", "UMLS:C0039529", "VHOG:0000698", "Wikipedia:Tensor_tympani_muscle" ; oboInOwl:hasExactSynonym "eustachian muscle", "tensor tympani muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "M. tensor tympani", "musculus tensor tympani", "tympanic muscle" ; oboInOwl:id "UBERON:0001600" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "tensor tympani" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004114 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010935 ], _:genid118150, _:genid118153, _:genid118156, _:genid118158 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004113 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001689 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/82/Gray912.png"^^xsd:anyURI . obo:UBERON_0001601 obo:IAO_0000115 "Skeletal muscle derived from cranial mesoderm and controls eye movements." ; obo:IAO_0000116 "todo - resolve discrepancies in which muscles are considered extra-ocular" ; obo:UBPROP_0000001 "Any of the six small muscles that control movement of the eyeball within the socket. [TFD][VHOG]", "Muscles surrounding the eye (bulbus oculi) and having an effect on eye movements.[AAO]" ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these (extrinsic ocular) muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; obo:UBPROP_0000007 "extraocular" ; obo:UBPROP_0000008 "Mammals have 7 extra-ocular muscles, but humans lack the M. retractor bulbi." ; obo:UBPROP_0000011 "Myofibers in extraocular muscles are derived from mesoderm, whereas muscle connective tissue cells arise from neural crest.[PMID:16638982]" ; obo:UBPROP_0000012 "BTO and MA consider this part of the eye; we follow them here (inferred from skeletal muscle). Not clear if omission from FMA is deliberate." ; oboInOwl:hasAlternativeId "UBERON:0006229" ; oboInOwl:hasDbXref "AAO:0010028", "BTO:0001579", "CALOHA:TS-0305", "EFO:0001921", "EHDAA2:0000482", "EHDAA:5729", "EMAPA:18234", "FMA:49033", "MA:0001271", "SCTID:181150000", "TAO:0000511", "VHOG:0000549", "Wikipedia:Extraocular_muscles", "ZFA:0000511" ; oboInOwl:hasExactSynonym "extra-ocular skeletal muscle", "extraocular muscle", "extraocular musculature", "extraocular skeletal muscle", "extrinsic eye muscle", "extrinsic muscle of eyeball", "extrinsic ocular muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculi externi bulbi oculi" ; oboInOwl:id "UBERON:0001601" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "extra-ocular muscle" ; rdfs:subClassOf obo:UBERON_0014892, _:genid118167, _:genid118169, _:genid118171, _:genid118173 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/61/MRI_of_human_eye.jpg"^^xsd:anyURI . obo:UBERON_0001602 obo:IAO_0000115 "The medial rectus muscle is a muscle in the orbit. As with most of the muscles of the orbit, it is innervated by the inferior division of the oculomotor nerve (Cranial Nerve III). This muscle shares an origin with several other extrinsic eye muscles, the anulus tendineus, or common tendon. It is the largest of the extraocular muscles and its only action is adduction of the eyeball. [WP,unvetted]." ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0004836" ; oboInOwl:hasDbXref "AAO:0010113", "FMA:49037", "MA:0001281", "NCIT:C33068", "SCTID:181151001", "TAO:0000301", "UMLS:C0582820", "VHOG:0001127", "Wikipedia:Medial_rectus_muscle", "ZFA:0000301" ; oboInOwl:hasExactSynonym "m. rectus medialis", "medial rectus", "medial rectus extraocular muscle", "medial rectus muscle", "musculus rectus medialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial recti", "musculus rectus medialis bulbi" ; oboInOwl:id "UBERON:0001602" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Taxon notes (from VHOG): \"The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.\" Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective, Third Edition (2001) Orlando Fla.: Harcourt College Publishers, p.331 [VHOG:0001127]" ; rdfs:label "medial rectus extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006533, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002376 ], _:genid118189 ; owl:disjointWith obo:UBERON_0001603 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0001603 obo:IAO_0000115 "The lateral rectus muscle is a muscle in the orbit. It is one of six extraocular muscles that control the movements of the eye (abduction in this case) and the only muscle innervated by the abducens nerve, cranial nerve VI. [WP,unvetted]." ; obo:UBPROP_0000001 "Cranial nerve VI innervated; lateral in the rectus group.[AAO]" ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0004837" ; oboInOwl:hasDbXref "AAO:0010107", "FMA:49038", "MA:0001280", "NCIT:C32945", "SCTID:181152008", "TAO:0000383", "UMLS:C0582821", "VHOG:0001129", "Wikipedia:Lateral_rectus_muscle", "ZFA:0000383" ; oboInOwl:hasExactSynonym "M. rectus lateralis", "lateral rectus", "lateral rectus extraocular muscle", "lateral rectus muscle", "musculus rectus lateralis", "posterior rectus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral extraocular muscle", "lateral recti", "musculus rectus lateralis bulbi" ; oboInOwl:id "UBERON:0001603" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lateral rectus extra-ocular muscle" ; rdfs:subClassOf obo:UBERON_0006533, _:genid118201 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0001604 obo:IAO_0000115 "The levator palpebrae superioris (or levator muscle of upper eyelid) is the muscle in the orbit that elevates the superior (upper) eyelid. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:36652", "FMA:49041", "MA:0001272", "NCIT:C52802", "SCTID:244774006", "UMLS:C0224134", "Wikipedia:Levator_palpebrae_superioris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001604" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "levator palpebrae superioris" ; rdfs:subClassOf obo:UBERON_0001601, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001677 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0004772 ], _:genid118214 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0001605 obo:IAO_0000115 "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0000654", "EMAPA:35240", "FMA:49151", "MA:0001269", "NCIT:C32315", "SCTID:280862009", "UMLS:C0559230", "Wikipedia:Ciliary_muscle" ; oboInOwl:hasExactSynonym "musculus ciliarus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Bowman`s muscles", "ciliaris", "musculus ciliaris" ; oboInOwl:id "UBERON:0001605" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ciliary muscle" ; rdfs:subClassOf obo:UBERON_0003386, obo:UBERON_0011222, [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 ], _:genid118222 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png"^^xsd:anyURI . obo:UBERON_0001606 obo:IAO_0000115 "." ; obo:IAO_0000116 "revisit this, see issue #331" ; obo:UBPROP_0000008 "The muscle cells of the iris are smooth muscle in mammals and amphibians, but are striated muscle in birds and reptiles. Many fish have neither, and, as a result, their irides are unable to dilate and contract, so that the pupil always remains of a fixed size[Romer, via WP]", "in aves, stromal mesenchymal cells may migrate to the iris and become skeletal" ; oboInOwl:hasDbXref "EMAPA:35448", "FMA:49154", "MA:0001287", "SCTID:280888007", "Wikipedia:Iris_muscle" ; oboInOwl:hasExactSynonym "iris muscle", "iris muscle organ", "muscle organ of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001606" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "muscle of iris" ; rdfs:subClassOf obo:UBERON_0011222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] . obo:UBERON_0001607 obo:IAO_0000115 "A sphincter muscle that is part of the iris." ; obo:UBPROP_0000008 "In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted]", "WP says: It is found in vertebrates and some cephalopods; this class refers to the vertebrate structure" ; obo:UBPROP_0000009 "constricts iris" ; oboInOwl:hasDbXref "BTO:0000656", "EMAPA:35788", "FMA:49157", "MA:0001289", "NCIT:C33586", "SCTID:280889004", "UMLS:C0229189", "Wikipedia:Iris_sphincter_muscle" ; oboInOwl:hasExactSynonym "M. sphincter pupillae", "iris sphincter muscle", "musculus sphincter pupillae", "sphincter muscle of pupil" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "circular fibers", "constrictor pupillae", "iris constrictor", "iris constrictor muscle", "iris sphincter", "m. sphincter pupillae", "pupillary constrictor muscle", "pupillary sphincter", "pupillary sphincter muscle", "sphincter pupillae", "sphincter pupillae muscle", "spincter pupillae" ; oboInOwl:id "UBERON:0001607" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "sphincter pupillae" ; rdfs:subClassOf obo:UBERON_0004234, _:genid118244, _:genid118246, _:genid118248, _:genid118250 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid117786 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png"^^xsd:anyURI . obo:UBERON_0001608 obo:IAO_0000115 "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." ; obo:UBPROP_0000009 "It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on alpha1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina" ; oboInOwl:hasDbXref "BTO:0001371", "EMAPA:35286", "FMA:49158", "MA:0001288", "NCIT:C32463", "SCTID:280890008", "UMLS:C0229190", "Wikipedia:Iris_dilator_muscle" ; oboInOwl:hasExactSynonym "dilator muscle of pupil", "dilator of pupil", "dilator pupillae", "dilator pupillae muscle", "iris dilator muscle", "musculus dilatator pupillae", "pupillary dilator muscle", "radial muscle of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dilator pupillae muscle", "iris dilator", "musculus dilatator pupillae", "musculus dilator pupillae", "pupil dilator", "pupil dilator muscle", "pupillary dilator", "pupillary muscle", "radial muscle", "radiating fibers" ; oboInOwl:id "UBERON:0001608" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "dilatator pupillae" ; rdfs:subClassOf obo:UBERON_0004234, _:genid118269, _:genid118271, _:genid118273, _:genid118275 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png"^^xsd:anyURI . obo:UBERON_0001610 obo:IAO_0000115 "The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP]." ; obo:UBPROP_0000001 "Part of the external carotid which supplies blood to the tongue.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of external carotid (AAO:0010218)[AAO]" ; oboInOwl:hasDbXref "AAO:0010492", "EMAPA:36324", "FMA:49526", "MA:0001992", "NCIT:C52961", "SCTID:181327002", "UMLS:C0226104", "Wikipedia:Lingual_artery" ; oboInOwl:hasExactSynonym "lingual branch of external carotid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria lingualis" ; oboInOwl:id "UBERON:0001610" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "lingual artery" ; rdfs:subClassOf _:genid118298, _:genid118300 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG"^^xsd:anyURI . obo:UBERON_0001611 obo:IAO_0000115 "A branch of the lingual artery that supplies the sublingual gland." ; obo:IAO_0000116 "Check grouping with amphibian structure of the same name" ; obo:UBPROP_0000001 "Part of the external carotid which supplies blood to the tip of the snout where branches go to the tongue and the m. geniohyoideus.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of external carotid (AAO:0010218)[AAO]" ; oboInOwl:hasDbXref "AAO:0010491", "EMAPA:37115", "FMA:49543", "MA:0002049", "NCIT:C53002", "SCTID:368706006", "UMLS:C0226106", "Wikipedia:Sublingual_artery" ; oboInOwl:hasExactSynonym "sublingual branch of lingual artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria sublingualis" ; oboInOwl:id "UBERON:0001611" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "sublingual artery" ; rdfs:subClassOf _:genid118311 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001832 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7a/Gray559.png"^^xsd:anyURI . obo:UBERON_0001612 obo:IAO_0000115 "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:19213", "FMA:49549", "MA:0001950", "NCIT:C32578", "SCTID:181328007", "UMLS:C0226109", "Wikipedia:Facial_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria maxillaris externa", "external maxillary artery" ; oboInOwl:id "UBERON:0001612" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "facial artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001456 ] _:genid117858 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png"^^xsd:anyURI . obo:UBERON_0001613 obo:IAO_0000115 "The occipital artery arises opposite the facial artery, its path is below the posterior belly of digastric to the occipital region. This artery supplies blood to the back of the scalp and sterno-mastoid muscles. Other muscles it supplies are deep muscles in the back and neck. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37672", "FMA:49586", "MA:0002009", "NCIT:C33194", "SCTID:244219005", "UMLS:C0226117", "Wikipedia:Occipital_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria occipitalis" ; oboInOwl:id "UBERON:0001613" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "occipital artery" ; owl:equivalentClass _:genid117863 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png"^^xsd:anyURI . obo:UBERON_0001616 obo:IAO_0000115 "An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]." ; obo:UBPROP_0000011 "...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries" ; oboInOwl:hasDbXref "EHDAA2:0001069", "EHDAA:7357", "EMAPA:17311", "FMA:49675", "GAID:498", "MA:0001919", "MESH:D008438", "NCIT:C34205", "SCTID:181326006", "UMLS:C0024949", "Wikipedia:Maxillary_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria maxillaris", "internal maxillary artery" ; oboInOwl:id "UBERON:0001616" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "maxillary artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001070 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002207 ; owl:someValuesFrom obo:UBERON_0003118 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png"^^xsd:anyURI . obo:UBERON_0001617 obo:IAO_0000115 "The mental branch of inferior alveolar artery escapes with the nerve at the mental foramen, supplies the chin, and anastomoses with the submental and inferior labial arteries. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37105", "FMA:49701", "MA:0002002", "NCIT:C52973", "SCTID:147561008", "UMLS:C0226144", "Wikipedia:Mental_part_of_inferior_alveolar_artery" ; oboInOwl:hasExactSynonym "mental branch of inferior alveolar artery", "ramus mentalis (arteria alveolaris inferior)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001617" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "mental artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0008199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0014693 ] ) ] . obo:UBERON_0001618 obo:IAO_0000115 "The buccal artery (buccinator artery) is small and runs obliquely forward, between the Pterygoideus internus and the insertion of the Temporalis, to the outer surface of the Buccinator, to which it is distributed, anastomosing with branches of the external maxillary and with the infraorbital. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37073", "FMA:49754", "MA:0001924", "NCIT:C52847", "SCTID:148066005", "UMLS:C0226151", "Wikipedia:Buccal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria buccalis", "arteria buccinatoria" ; oboInOwl:id "UBERON:0001618" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "buccal artery" ; owl:equivalentClass _:genid117894 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png"^^xsd:anyURI . obo:UBERON_0001619 obo:IAO_0000115 "The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified]." ; obo:UBPROP_0000001 "Part of internal carotid which carries blood via branches to the eye, the eye muscles, and eyelids.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of internal carotid (AAO:0010219)[AAO]" ; oboInOwl:hasDbXref "AAO:0010497", "EHDAA2:0001300", "EHDAA:7363", "EMAPA:17007", "FMA:49868", "GAID:503", "MA:0002011", "MESH:D009880", "NCIT:C33216", "SCTID:181310005", "UMLS:C0029078", "Wikipedia:Ophthalmic_artery", "XAO:0000368" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria ophthalmica", "opthalmic artery" ; oboInOwl:id "UBERON:0001619" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "ophthalmic artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001532 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png"^^xsd:anyURI . obo:UBERON_0001620 obo:IAO_0000115 "The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37113", "FMA:49879", "GAID:508", "MA:0002038", "MESH:D012161", "NCIT:C52997", "SCTID:277771001", "UMLS:C0035301", "Wikipedia:Central_retinal_artery" ; oboInOwl:hasExactSynonym "Zinn's artery", "central artery of retina", "retinal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria centralis retinae", "central artery of the retina" ; oboInOwl:id "UBERON:0001620" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "central retinal artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004864 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000966 ], _:genid118381, _:genid118383 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/59/Gray514_updated.png"^^xsd:anyURI . obo:UBERON_0001621 obo:IAO_0000115 "An artery that supplies the myocardium." ; oboInOwl:hasDbXref "BTO:0000290", "CALOHA:TS-0176", "EFO:0002551", "EMAPA:19160", "EV:0100383", "FMA:49893", "MA:0002453", "NCIT:C12843", "SCTID:181294004", "UMLS:C0205042", "VHOG:0001557", "Wikipedia:Coronary_circulation#Coronary_anatomy", "ZFA:0005812", "galen:CoronaryArtery" ; oboInOwl:hasExactSynonym "coronary arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coronary vessel" ; oboInOwl:id "UBERON:0001621" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "coronary artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002349 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png"^^xsd:anyURI . obo:UBERON_0001622 obo:IAO_0000115 "The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37094", "FMA:49927", "MA:0001988", "NCIT:C52948", "SCTID:369324002", "UMLS:C0226171", "Wikipedia:Lacrimal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "a. lacrimalis" ; oboInOwl:id "UBERON:0001622" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "lacrimal artery" ; rdfs:subClassOf _:genid118399 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001817 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png"^^xsd:anyURI . obo:UBERON_0001623 obo:IAO_0000115 "The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:35292", "FMA:50000", "MA:0001945", "NCIT:C52983", "SCTID:369333000", "UMLS:C0226194", "Wikipedia:Dorsal_nasal_artery" ; oboInOwl:hasExactSynonym "dorsal nasal branch of ophthalmic artery", "external nasal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria dorsalis nasi" ; oboInOwl:id "UBERON:0001623" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "dorsal nasal artery" ; rdfs:subClassOf obo:UBERON_0015156 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray515.png"^^xsd:anyURI . obo:UBERON_0001627 obo:IAO_0000115 "The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it then branches and projects to many parts of the lateral cerebral cortex. It also supplies blood to the anterior temporal lobes and the insular cortices. The left and right MCAs rise from trifurcations of the internal carotid arteries and thus are connected to the anterior cerebral arteries and the posterior communicating arteries, which connect to the posterior cerebral arteries. The MCAs are not considered a part of the Circle of Willis. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0005206", "EHDAA2:0001179", "EHDAA:5298", "EMAPA:18239", "FMA:50079", "GAID:487", "MA:0001935", "MESH:D020768", "NCIT:C12830", "SCTID:181312002", "UMLS:C0149566", "Wikipedia:Middle_cerebral_artery" ; oboInOwl:hasExactSynonym "Sylvian artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria cerebri media" ; oboInOwl:id "UBERON:0001627" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "middle cerebral artery" ; rdfs:subClassOf obo:UBERON_0004449, _:genid118411 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg"^^xsd:anyURI . obo:UBERON_0001628 obo:IAO_0000115 "One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery." ; obo:UBPROP_0000001 "An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery. Isogai et al. 2001.[TAO]" ; obo:UBPROP_0000008 "todo - verify ZFA link: An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery" ; oboInOwl:hasDbXref "EHDAA2:0004518", "EHDAA:3352", "EMAPA:18600", "FMA:50084", "MA:0002023", "NCIT:C33357", "RETIRED_EHDAA2:0001487", "SCTID:181314001", "TAO:0005001", "UMLS:C0149559", "Wikipedia:Posterior_communicating_artery", "ZFA:0005001" ; oboInOwl:hasExactSynonym "caudal communicating segment", "posterior communicating segment of the basilar artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PCA", "PCS", "arteria cerebri communicans posterior" ; oboInOwl:id "UBERON:0001628" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "posterior communicating artery" ; rdfs:subClassOf _:genid118422, _:genid118424 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006347 _:genid117949 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001532 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg"^^xsd:anyURI . obo:UBERON_0001630 obo:IAO_0000115 "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." ; obo:UBPROP_0000001 "Portion of tissue composed of contractile fibers.[TAO]" ; obo:UBPROP_0000003 "It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG]" ; obo:UBPROP_0000007 "muscular" ; oboInOwl:hasBroadSynonym "muscle" ; oboInOwl:hasDbXref "AAO:0011066", "EMAPA:32715", "EMAPA:37474", "EV:0100146", "FMA:5022", "GAID:131", "MA:0000015", "SCTID:71616004", "TAO:0005145", "VHOG:0001245", "XAO:0000172", "ZFA:0005145", "galen:Muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001630" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "muscle organ" ; rdfs:subClassOf obo:UBERON_0005090, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002385 ] ) ] . obo:UBERON_0001631 obo:IAO_0000115 "A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins." ; obo:IAO_0000116 "placement of the ZFA class here is dubious" ; obo:UBPROP_0000001 "Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein.", "The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein." ; oboInOwl:hasDbXref "EHDAA2:0004501", "EMAPA:19310", "FMA:5031", "GAID:1290", "MA:0002801", "MESH:D013897", "NCIT:C33768", "SCTID:362600004", "TAO:0005110", "UMLS:C0039979", "Wikipedia:Thoracic_duct", "ZFA:0005110" ; oboInOwl:hasExactSynonym "trunk of thoracic duct tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus thoracicus" ; oboInOwl:id "UBERON:0001631" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "thoracic duct" ; rdfs:subClassOf obo:UBERON_0001473, _:genid118442, _:genid118444 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray599.png"^^xsd:anyURI . obo:UBERON_0001633 obo:IAO_0000115 "A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain." ; obo:UBPROP_0000001 "Artery that runs along the ventral keel of the hindbrain. It lies between the primordial hindbrain channels(PHBC). It irrigates the hindbrain and is connected, through the hindbrain, to the PHBC by the central arteries.", "The unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear[MP]." ; obo:UBPROP_0000003 "The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000163", "EHDAA:5285", "EMAPA:17307", "FMA:50542", "GAID:474", "MA:0001920", "MESH:D001488", "NCIT:C12676", "SCTID:244215004", "TAO:0005002", "UMLS:C0004811", "VHOG:0000237", "Wikipedia:Basilar_artery", "ZFA:0005002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "BA" ; oboInOwl:id "UBERON:0001633" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:unverified_taxonomic_grouping, core:vertebrate_core ; a owl:Class ; rdfs:label "basilar artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002200 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002028 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001535 ], _:genid118454 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg"^^xsd:anyURI . obo:UBERON_0001635 obo:IAO_0000115 "The superior cerebellar artery (SCA) arises near the termination of the basilar artery. It passes lateralward, immediately below the oculomotor nerve, which separates it from the posterior cerebral artery, winds around the cerebral peduncle, close to the trochlear nerve, and, arriving at the upper surface of the cerebellum, divides into branches which ramify in the pia mater and anastomose with those of the inferior cerebellar arteries. Several branches are given to the pineal body, the anterior medullary velum, and the tela chorioidea of the third ventricle. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0000681", "EMAPA:19309", "FMA:50573", "MA:0001934", "NCIT:C33669", "SCTID:244214000", "UMLS:C0149575", "Wikipedia:Superior_cerebellar_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria superior cerebelli" ; oboInOwl:id "UBERON:0001635" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "superior cerebellar artery" ; owl:equivalentClass _:genid117988 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/CerebellumArteries.jpg"^^xsd:anyURI . obo:UBERON_0001637 obo:IAO_0000115 "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." ; obo:IAO_0000116 "Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme." ; obo:UBPROP_0000001 "Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO]" ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; obo:UBPROP_0000007 "arterial" ; obo:UBPROP_0000012 "Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system." ; obo:UBPROP_0000202 obo:FMA_63812 ; oboInOwl:hasDbXref "AAO:0010211", "AEO:0000208", "BTO:0000573", "CALOHA:TS-0054", "EFO:0000814", "EHDAA2:0000143", "EHDAA2:0003253", "EMAPA:35147", "EV:0100026", "FMA:50720", "GAID:468", "MA:0000064", "MAT:0000034", "MESH:D001158", "MIAA:0000034", "NCIT:C12372", "SCTID:362877004", "TAO:0000005", "UMLS:C0003842", "VHOG:0001251", "Wikipedia:Artery", "XAO:0000114", "ZFA:0000005", "galen:Artery" ; oboInOwl:hasExactSynonym "arterial subtree", "arterial tree organ part", "arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arterial system", "arterial vessel" ; oboInOwl:id "UBERON:0001637" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "artery" ; rdfs:subClassOf obo:UBERON_0001981, _:genid118001, [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0000948 ] . obo:UBERON_0001638 obo:IAO_0000115 "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." ; obo:IAO_0000116 "TODO - check with MA - vein vs venous blood vessel" ; obo:UBPROP_0000001 "Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]" ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; obo:UBPROP_0000007 "venous" ; obo:UBPROP_0000202 obo:FMA_63814 ; oboInOwl:hasBroadSynonym "venous subtree", "venous vessel" ; oboInOwl:hasDbXref "AAO:0010212", "AEO:0000209", "BTO:0000234", "CALOHA:TS-1108", "EFO:0000816", "EHDAA2:0003254", "EMAPA:35906", "EV:0100031", "FMA:50723", "GAID:492", "MA:0000067", "MAT:0000037", "MESH:D014680", "MIAA:0000037", "NCIT:C12814", "SCTID:181367001", "TAO:0000082", "UMLS:C0042449", "VHOG:0001743", "Wikipedia:Vein", "XAO:0000115", "ZFA:0000082", "galen:Vein" ; oboInOwl:hasExactSynonym "venous tree organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vascular element", "vena", "venae" ; oboInOwl:id "UBERON:0001638" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001982 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003920 [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0013756 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg"^^xsd:anyURI . obo:UBERON_0001639 obo:IAO_0000115 "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." ; obo:UBPROP_0000003 "Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans A vein in the abdominal cavity that drains blood from the gastrointestinal tract and spleen. It is usually formed by the confluence of the superior mesenteric and splenic veins, and also receives blood from the inferior mesenteric, gastric, and cystic veins. The hepatic portal vein is a major component of the hepatic portal system, one of the main portal venous systems in the body. Conditions involving the hepatic portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the hepatic portal vein. This condition, called portal hypertension, is a major complication of cirrhosis worldwide. [WP,unvetted]" ; oboInOwl:hasDbXref "AAO:0010214", "FMA:50735", "MA:0002132", "TAO:0005090", "VHOG:0000642", "Wikipedia:Hepatic_portal_vein", "ZFA:0005090" ; oboInOwl:hasExactSynonym "hepatic portal tree", "liver portal vein", "portal vein of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "HPV", "portal vein", "primary hepatic portal vein", "primary hepatic portal veins", "vena portae hepatis" ; oboInOwl:id "UBERON:0001639" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatic portal vein" ; rdfs:subClassOf obo:UBERON_0002017, _:genid118020, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002107 ], _:genid118022 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png"^^xsd:anyURI . obo:UBERON_0001640 obo:IAO_0000115 "The first major branch of the abdominal aorta." ; oboInOwl:hasDbXref "EHDAA2:0004519", "EMAPA:35202", "FMA:50737", "GAID:483", "MA:0001931", "MESH:D002445", "NCIT:C52846", "SCTID:181340007", "UMLS:C0007569", "Wikipedia:Celiac_artery" ; oboInOwl:hasExactSynonym "celiac tree", "coeliac artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria coeliaca", "arteria cœliaca", "celiac trunk", "coeliac axis", "coeliac trunck", "coeliac trunk", "truncus coeliacus", "truncus cœliacus" ; oboInOwl:id "UBERON:0001640" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "dorsal aorta in Kardong" ; rdfs:label "celiac artery" ; rdfs:subClassOf obo:UBERON_0004573, _:genid118506, _:genid118508, _:genid118510, _:genid118512, _:genid118514 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png"^^xsd:anyURI . obo:UBERON_0001641 obo:IAO_0000115 "One of the dural venous sinuses and drains the superior sagittal sinus the occipital sinus and the straight sinus, and empties into the sigmoid sinus which in turn reaches the jugular bulb." ; obo:IAO_0000116 "TODO - check subclasses" ; oboInOwl:hasDbXref "EMAPA:18637", "FMA:50763", "MA:0001868", "SCTID:279262004", "Wikipedia:Transverse_sinuses", "ncithesaurus:Transverse_Sinus" ; oboInOwl:hasExactSynonym "sinus transversus durae matris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "groove for right and left transverse sinuses", "lateral sinus", "sinus transversus", "transverse sinus", "transverse sinus vein" ; oboInOwl:id "UBERON:0001641" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "transverse sinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017635 [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0005475 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif"^^xsd:anyURI . obo:UBERON_0001643 obo:IAO_0000115 "Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles." ; obo:UBPROP_0000001 "Somatic efferent fibers which innervate four eye muscles.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "3n" ; oboInOwl:hasDbXref "AAO:0010468", "BAMS:3n", "BAMS:IIIn", "BIRNLEX:1646", "BM:MB-IIIN", "EHDAA2:0001284", "EHDAA:3736", "EMAPA:17574", "FMA:50864", "GAID:829", "HBA:9316", "MA:0001095", "MBA:832", "MESH:D009802", "NCIT:C12758", "SCTID:362456009", "TAO:0000405", "UMLS:C0028864", "VHOG:0000692", "Wikipedia:Oculomotor_nerve", "XAO:0003090", "ZFA:0000405", "neuronames:488" ; oboInOwl:hasExactSynonym "nervus oculomotorius", "nervus oculomotorius [III]", "oculomotor III", "oculomotor III nerve", "oculomotor nerve [III]", "oculomotor nerve tree", "third cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-III", "cranial nerve III", "nerve III", "occulomotor", "oculomotor nerve or its root" ; oboInOwl:id "UBERON:0001643" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "oculomotor nerve" ; rdfs:subClassOf _:genid118547 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0011222 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001715 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png"^^xsd:anyURI . obo:UBERON_0001644 obo:IAO_0000115 "A cranial nerve that runs to the eye muscles." ; obo:UBPROP_0000001 "Somatic efferent nerve which supplies a single eye muscle, the m. obliquus superior.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; obo:UBPROP_0000008 "Homologous trochlear nerves are found in all jawed vertebrates" ; obo:UBPROP_0000011 "The human trochlear nerve is derived from the basal plate of the embryonic midbrain." ; oboInOwl:hasBroadSynonym "4n" ; oboInOwl:hasDbXref "AAO:0010469", "BAMS:4n", "BAMS:IVn", "BAMS:nIV", "BIRNLEX:1654", "BM:IVN", "EHDAA2:0002090", "EMAPA:18218", "FMA:50865", "GAID:838", "HBA:9319", "MA:0001105", "MBA:911", "MESH:D014321", "NCIT:C12808", "SCTID:180939009", "TAO:0000600", "UMLS:C0041159", "VHOG:0000705", "Wikipedia:Trochlear_nerve", "XAO:0003091", "ZFA:0000600", "neuronames:466" ; oboInOwl:hasExactSynonym "cranial nerve IV", "fourth cranial nerve", "nervus trochlearis [IV]", "superior oblique nerve", "trochlear IV nerve", "trochlear nerve [IV]", "trochlear nerve tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-IV", "nerve IV", "nervus trochlearis", "pathetic nerve", "trochlear", "trochlear nerve or its root", "trochlear nerve/root" ; oboInOwl:id "UBERON:0001644" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trochlear nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006321 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002722 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/33/Trochlear_nerve.png"^^xsd:anyURI . obo:UBERON_0001645 obo:IAO_0000115 "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." ; obo:UBPROP_0000001 "Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; obo:UBPROP_0000008 "the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls" ; oboInOwl:hasBroadSynonym "5n" ; oboInOwl:hasDbXref "AAO:0010470", "BAMS:5n", "BAMS:Vn", "BAMS:nV", "BIRNLEX:869", "BM:VN", "BTO:0001072", "EFO:0001402", "EHDAA2:0002084", "EHDAA:3738", "EMAPA:17576", "FMA:50866", "GAID:726", "HBA:9322", "MA:0001100", "MBA:901", "MESH:D014276", "MFMO:0000093", "NCIT:C12806", "SCTID:362459002", "TAO:0000697", "UMLS:C0040996", "VHOG:0000704", "Wikipedia:Trigeminal_nerve", "XAO:0003092", "ZFA:0000697", "neuronames:549" ; oboInOwl:hasExactSynonym "fifth cranial nerve", "nervus trigeminus", "nervus trigeminus [v]", "trigeminal V", "trigeminal nerve [V]", "trigeminal nerve tree", "trigeminal v nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-V", "cranial nerve V", "nerve V", "nervus trigeminus", "trigeminus" ; oboInOwl:id "UBERON:0001645" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trigeminal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003099 ], _:genid118592 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 _:genid118103 _:genid118105 _:genid118107 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002925 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png"^^xsd:anyURI . obo:UBERON_0001646 obo:IAO_0000115 "Cranial nerve that runs to the eye muscles." ; obo:UBPROP_0000001 "Somatic motor nerve which bifurcates innervating m. rectus lateralis and m. retractor bulbi (eye muscles).[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; obo:UBPROP_0000008 "Homologous abducens nerves are found in all vertebrates except lampreys and hagfishes.[WP] It controls the movement of a single muscle, the lateral rectus muscle of the eye, in humans. In most other mammals it also innervates the musculus retractor bulbi, which can retract the eye for protection" ; oboInOwl:hasBroadSynonym "6n" ; oboInOwl:hasDbXref "AAO:0010471", "BAMS:VIn", "BIRNLEX:876", "BM:Pons-VIN", "EHDAA2:0000103", "EMAPA:18216", "FMA:50867", "GAID:824", "HBA:9325", "MA:0001087", "MBA:710", "MESH:D000010", "NCIT:C12665", "SCTID:180941005", "TAO:0000310", "UMLS:C0000741", "VHOG:0000697", "Wikipedia:Abducens_nerve", "XAO:0003093", "ZFA:0000310", "neuronames:550" ; oboInOwl:hasExactSynonym "abducens VI nerve", "abducens nerve [VI]", "abducens nerve tree", "abducent nerve [VI]", "lateral rectus nerve", "nervus abducens", "nervus abducens [VI]", "sixth cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-VI", "abducens nerve/root", "abducent nerve", "abducents VI nerve", "cranial nerve VI", "nerve VI", "nervus abducens" ; oboInOwl:id "UBERON:0001646" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "abducens nerve" ; rdfs:subClassOf _:genid118613 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001601 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002682 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/29/Abducens_nerve1.png"^^xsd:anyURI . obo:UBERON_0001647 obo:IAO_0000115 "Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches)." ; obo:UBPROP_0000001 "Slender nerve composed of branchiomotor and visceral efferent fibers innervating the mouth and various muscles within the jaw. Sensory components innervate the bucccal roof and somatomotor components innervate the depressor musculature and muscle interhyoideus.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "7n" ; oboInOwl:hasDbXref "AAO:0010472", "BAMS:7n", "BAMS:VIIn", "BAMS:Viin", "BAMS:nVII", "BIRNLEX:827", "BM:Pons-VIIN", "EHDAA2:0000489", "EHDAA:3729", "EMAPA:17796", "FMA:50868", "GAID:719", "HBA:9328", "MA:0001091", "MBA:798", "MESH:D005154", "NCIT:C12714", "SCTID:362460007", "TAO:0000664", "UMLS:C0015462", "VHOG:0000706", "Wikipedia:Facial_nerve", "XAO:0003094", "ZFA:0000664", "neuronames:551" ; oboInOwl:hasExactSynonym "branchiomeric cranial nerve", "face nerve", "facial VII", "facial VII nerve", "facial nerve [VII]", "facial nerve tree", "nerve of face", "nervus facialis", "nervus facialis [vii]", "seventh cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-VII", "cranial nerve VII", "facial nerve or its root", "facial nerve/root", "nerve VII", "nervus facialis" ; oboInOwl:id "UBERON:0001647" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "facial nerve" ; rdfs:subClassOf obo:UBERON_0001785, _:genid118633, _:genid118635, _:genid118637, _:genid118639 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001577 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000127 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Cranial_nerve_VII.svg"^^xsd:anyURI . obo:UBERON_0001648 obo:IAO_0000115 "Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain." ; obo:UBPROP_0000001 "Nerve primarily composed of special somatic afferent fibers innervating the inner ear, and is involved in balance, position, and hearing.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "8n" ; oboInOwl:hasDbXref "AAO:0010473", "BAMS:8n", "BAMS:VIIIn", "BAMS:nVIII", "BIRNLEX:890", "BTO:0003490", "EHDAA2:0002194", "EMAPA:17801", "FMA:50869", "GAID:839", "HBA:9331", "MA:0001109", "MBA:933", "MESH:D000159", "NCIT:C12996", "SCTID:180945001", "TAO:0000247", "UMLS:C0001162", "UMLS:C1278835", "VHOG:0000695", "Wikipedia:Vestibulocochlear_nerve", "XAO:0003095", "ZFA:0000247", "neuronames:553" ; oboInOwl:hasExactSynonym "CN-VIII", "VIII nerve", "VIIIth cranial nerve", "acoustic VIII nerve", "acoustic nerve", "acoustic nerve (Crosby)", "cochlear-vestibular nerve", "cochleovestibular nerve", "cranial nerve VIII", "eighth cranial nerve", "nervus vestibulocochlearis [viii]", "stato-acoustic nerve", "vestibulocochlear VIII nerve", "vestibulocochlear nerve [VIII]", "vestibulocochlear nerve tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus octavus", "nervus statoacusticus", "nervus vestibulocochlearis", "octaval nerve", "statoacoustic nerve" ; oboInOwl:id "UBERON:0001648" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vestibulocochlear nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002105 ], _:genid118663 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid118171 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png"^^xsd:anyURI . obo:UBERON_0001649 obo:IAO_0000115 "Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult)." ; obo:UBPROP_0000001 "Small nerve consisting of branchiomotor and visceral efferent and afferent fibers which innervate the m. subarculais rectus I, dorsal buccal mucosa, and the tongue.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "9n" ; oboInOwl:hasDbXref "AAO:0010474", "BAMS:9n", "BAMS:IXn", "BIRNLEX:899", "BTO:0004979", "EHDAA2:0000709", "EHDAA:3733", "EMAPA:17268", "FMA:50870", "GAID:827", "HBA:9334", "MA:0001093", "MBA:808", "MESH:D005930", "NCIT:C12723", "SCTID:362465002", "TAO:0000668", "UMLS:C0017679", "UMLS:C1305752", "VHOG:0000701", "Wikipedia:Glossopharyngeal_nerve", "XAO:0003096", "ZFA:0000668", "neuronames:701" ; oboInOwl:hasExactSynonym "glossopharyngeal IX", "glossopharyngeal IX nerve", "glossopharyngeal nerve [IX]", "glossopharyngeal nerve tree", "nervus glossopharyngeus", "nervus glossopharyngeus [ix]", "ninth cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-IX", "cranial nerve IX", "nerve IX", "nervus glossopharyngeus" ; oboInOwl:id "UBERON:0001649" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "glossopharyngeal nerve" ; rdfs:subClassOf obo:UBERON_0001785, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001727 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006562 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001896 ], _:genid118680, _:genid118682 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png"^^xsd:anyURI . obo:UBERON_0001650 obo:IAO_0000115 "Cranial nerve that innervates the muscles of the tongue." ; obo:UBPROP_0000001 "Cranial nerve that innervates muscles in the tongue. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-14, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]", "In amphibians, represents the hypoglossal nerve in amniotes. Innverates mm. geniohyoideus, genioglossus, hyoglossus, rectus cervicis", "Nerve which innervates the muscles associated with the tongue including mm geniohyoideus, genioglossus, hyoglossus and rectus cervicis.[AAO]" ; obo:UBPROP_0000003 "Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG]" ; obo:UBPROP_0000012 "we use a broad definition of this cranial nerve that encompasses the amphibian predecessor of true amniote hypoglossal nerves" ; oboInOwl:hasBroadSynonym "12n" ; oboInOwl:hasDbXref "AAO:0010477", "BAMS:12n", "BAMS:XIIn", "BAMS:nXII", "BIRNLEX:820", "BTO:0003386", "EHDAA2:0000798", "EHDAA:2859", "EMAPA:17269", "FMA:50871", "GAID:828", "HBA:9343", "MA:0001094", "MBA:813", "MESH:D007002", "NCIT:C12732", "SCTID:362471008", "UMLS:C0020614", "VHOG:0000693", "Wikipedia:Hypoglossal_nerve", "XAO:0004215", "neuronames:704" ; oboInOwl:hasExactSynonym "cranial nerve XII", "hypoglossal XII", "hypoglossal XII nerve", "hypoglossal nerve [XII]", "hypoglossal nerve tree", "nervus hypoglossus [xii]", "twelfth cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-XII", "hypoglossal nerve/ root", "nerve XII", "nervi hypoglossalis", "nervus hypoglossus" ; oboInOwl:id "UBERON:0001650" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hypoglossal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001571 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001572 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000378 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002871 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray794.png"^^xsd:anyURI . obo:UBERON_0001651 obo:IAO_0000115 "The pulmonary artery that supplies the right lung." ; obo:IAO_0000116 "TODO - add class 'pulmonary artery tree organ'" ; oboInOwl:hasDbXref "EMAPA:37378", "FMA:50872", "MA:0002500", "NCIT:C33489", "SCTID:244235003", "UMLS:C0923924", "Wikipedia:Right_pulmonary_artery", "galen:RightPulmonaryArtery" ; oboInOwl:hasExactSynonym "right main pulmonary artery", "right pulmonary arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria pulmonalis dextra" ; oboInOwl:id "UBERON:0001651" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "right pulmonary artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0001652 obo:IAO_0000115 "The pulmonary artery that supplies the left lung." ; obo:IAO_0000116 "TODO - add class 'pulmonary artery tree organ'" ; oboInOwl:hasDbXref "EMAPA:37097", "FMA:50873", "MA:0002032", "NCIT:C32971", "SCTID:244234004", "UMLS:C0923925", "Wikipedia:Left_pulmonary_artery", "galen:LeftPulmonaryArtery" ; oboInOwl:hasExactSynonym "left main pulmonary artery", "left pulmonary arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria pulmonalis sinistra" ; oboInOwl:id "UBERON:0001652" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "left pulmonary artery" ; rdfs:subClassOf _:genid118246 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 _:genid118244 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0001653 obo:IAO_0000115 "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." ; obo:UBPROP_0000001 "Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO]" ; obo:UBPROP_0000012 "MA and NCITA also has 'anterior facial vein'" ; oboInOwl:hasDbXref "AAO:0010513", "EMAPA:19220", "FMA:50874", "MA:0002115", "NCIT:C32579", "SCTID:181374006", "UMLS:C0226532", "Wikipedia:Facial_vein" ; oboInOwl:hasExactSynonym "face vein", "vein of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior facial vein", "vena facialis anterior" ; oboInOwl:id "UBERON:0001653" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "facial vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], _:genid118741 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png"^^xsd:anyURI . obo:UBERON_0001663 obo:IAO_0000115 "The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted]." ; obo:UBPROP_0000202 obo:FMA_70861 ; oboInOwl:hasDbXref "EMAPA:37140", "FMA:50981", "GAID:530", "MA:0002096", "MESH:D002550", "NCIT:C53037", "SCTID:244392000", "UMLS:C0007797", "Wikipedia:Cerebral_veins", "XAO:0004160" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae cerebri", "venae encephali" ; oboInOwl:id "UBERON:0001663" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebral vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Gray568.png"^^xsd:anyURI . obo:UBERON_0001665 obo:IAO_0000115 "The triceps surae is a pair of muscles located at the calf - the gastrocnemius and the soleus. These muscles both insert into the calcaneus, the bone of the heel of the human foot, and form the major part of the muscle of the back part of the lower leg, commonly known as the calf muscle. The triceps surae is connected to the foot through the Achilles tendon, and has 3 heads deriving from the 2 major masses of muscle. The superficial portion (the gastrocnemius) gives off 2 heads attaching to the base of the femur directly above the knee. The deep (profundis) mass of muscle (the soleus) forms the remaining head which attaches to the superior posterior area of the tibia. The triceps surae is innervated by the tibial nerve, specifically, nerve roots L5-S2. [WP,unvetted]." ; obo:UBPROP_0000012 "A set of muscles in FMA, a single organ in MA" ; oboInOwl:hasDbXref "EMAPA:36267", "FMA:51062", "MA:0002400", "NCIT:C53181", "UMLS:C0224458", "Wikipedia:Triceps_surae_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calf muscle", "gastrosoleus", "gastrosoleus complex", "musculus triceps surae", "sural triceps" ; oboInOwl:id "UBERON:0001665" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "triceps surae" ; rdfs:subClassOf obo:UBERON_0014892, _:genid118271, _:genid118762, _:genid118764, _:genid118766 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/57/Illu_lower_extremity_muscles.jpg"^^xsd:anyURI . obo:UBERON_0001667 obo:IAO_0000115 "The Tibialis posterior is the most central of all the leg muscles, and is located in the posterior compartment of the leg. It is the key stabilizing muscle of the lower leg. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0000867", "EMAPA:36255", "FMA:51099", "MA:0002394", "NCIT:C53078", "SCTID:361824007", "UMLS:C1711425", "Wikipedia:Tibialis_posterior_muscle" ; oboInOwl:hasExactSynonym "tibialis caudalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ibialis posticus", "musculus tibialis posterior", "posterior tibialis", "tibialis posterior muscle" ; oboInOwl:id "UBERON:0001667" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "tibialis posterior" ; rdfs:subClassOf obo:UBERON_0008230, _:genid118775, _:genid118777, _:genid118779, _:genid118781, _:genid118783, _:genid118785 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray442.png"^^xsd:anyURI . obo:UBERON_0001668 obo:IAO_0000115 "A vein that drains the cerebellum." ; oboInOwl:hasDbXref "EMAPA:37139", "FMA:51227", "MA:0002093", "NCIT:C53032", "SCTID:40693009", "UMLS:C0226601", "Wikipedia:Cerebellar_veins" ; oboInOwl:hasExactSynonym "cerebellum vein", "epencephalon-1 vein", "vein of cerebellum", "vein of epencephalon-1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001668" ; a owl:Class ; rdfs:label "cerebellar vein" ; rdfs:subClassOf obo:UBERON_0001638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0001674 obo:IAO_0000115 "A plexiform vein accompanying the masseteric artery that empty into the pterygoid venous plexus." ; oboInOwl:hasDbXref "EMAPA:37168", "FMA:52519", "MA:0002167", "NCIT:C53051", "UMLS:C0925179" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "masseteric veins" ; oboInOwl:id "UBERON:0001674" ; a owl:Class ; rdfs:label "masseteric vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0001675 obo:IAO_0000115 "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." ; obo:IAO_0000116 "consider renaming this 'trigeminal ganglion complex'. The complex may be fused (amniotes) partially fused (xenopus) or separate (sharks)" ; obo:UBPROP_0000001 "A prominent collection of touch-sensory neurons of the trigeminal or fifth cranial nerve, positioned beside the brain between the eye and the ear. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000008 "In Xenopus, the profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." ; oboInOwl:hasDbXref "AAO:0011107", "BAMS:5Gn", "BAMS:GV", "BTO:0001231", "EFO:0000903", "EHDAA2:0002085", "EHDAA:2113", "EMAPA:16797", "FMA:52618", "GAID:725", "MA:0001080", "MAT:0000511", "MESH:D012668", "NCIT:C62642", "SCTID:244449009", "TAO:0000295", "UMLS:C0040995", "VHOG:0000694", "Wikipedia:Trigeminal_ganglion", "XAO:0000427", "XAO:0000428", "ZFA:0000295", "neuronames:1402" ; oboInOwl:hasExactSynonym "5th ganglion", "Gasserian ganglion", "fifth ganglion", "ganglion of trigeminal complex", "semilunar ganglion", "trigeminal V ganglion" ; oboInOwl:hasNarrowSynonym "fused trigeminal ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Gasser's ganglion", "Gasserian ganglia", "gV", "ganglion of trigeminal nerve", "ganglion semilunare", "ganglion trigeminale", "trigeminal ganglia", "trigeminus ganglion" ; oboInOwl:id "UBERON:0001675" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trigeminal ganglion" ; rdfs:subClassOf obo:UBERON_0001800, _:genid118817 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001645 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png"^^xsd:anyURI . obo:UBERON_0001676 obo:IAO_0000115 "The bone at the lower, posterior part of the skull." ; obo:UBPROP_0000008 "formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII", "fusion of basi-, exo- and supra-occipitals (and maybe tabular)" ; oboInOwl:hasDbXref "EMAPA:25112", "FMA:52735", "GAID:227", "MA:0001468", "MESH:D009777", "NCIT:C12757", "SCTID:181796003", "UMLS:C0028784", "Wikipedia:Occipital_bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "occipital complex", "occipital squama", "os occipitale" ; oboInOwl:id "UBERON:0001676" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "occipital bone" ; rdfs:subClassOf obo:UBERON_0010428, [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0003687 ], _:genid118837, _:genid118839, _:genid118841, _:genid118843, _:genid118845 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png"^^xsd:anyURI . obo:UBERON_0001677 obo:IAO_0000115 "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." ; obo:UBPROP_0000012 "part of viscerocranium (facial skeleton) in FMA" ; oboInOwl:hasDbXref "CALOHA:TS-2343", "EMAPA:18340", "FMA:52736", "GAID:230", "MA:0001472", "MESH:D013100", "NCIT:C12790", "SCTID:272676008", "UMLS:C0037884", "Wikipedia:Sphenoid_bone" ; oboInOwl:hasExactSynonym "os sphenoidale", "sphenoid", "sphenoidal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "butterfly bone", "os sphenoidale", "os sphenoidum", "sphenoid complex" ; oboInOwl:id "UBERON:0001677" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sphenoid bone" ; rdfs:subClassOf obo:UBERON_0008193, _:genid118859, _:genid118861, _:genid118863, _:genid118865, _:genid118867 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015060 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg"^^xsd:anyURI . obo:UBERON_0001678 obo:IAO_0000115 "The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous." ; obo:UBPROP_0000008 "In many mammals, as in humans, the petrosal, ectotympanic and squamosal bones synostose to form the temporal bone + styloid process", "fusion of squamosal + angular (tympanic annulus) [derm.] + petrosal (prootic + opisthotic)" ; obo:UBPROP_0000010 "The temporal bone consists of four parts: * Squama temporalis * Mastoid portion * Petrous portion (Petrosal ridge) * Tympanic part[WP]." ; obo:UBPROP_0000012 "Note the Temporal bone is not explicitly categorized to a part of the cranium in FMA" ; oboInOwl:hasDbXref "EHDAA:6035", "EMAPA:17682", "FMA:52737", "GAID:232", "MA:0001476", "MESH:D013701", "NCIT:C12797", "SCTID:181795004", "UMLS:C0039484", "VHOG:0000800", "Wikipedia:Temporal_bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os temporale" ; oboInOwl:id "UBERON:0001678" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "temporal bone" ; rdfs:subClassOf obo:UBERON_0008193, _:genid118877, _:genid118879, _:genid118881 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg"^^xsd:anyURI . obo:UBERON_0001679 obo:IAO_0000115 "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." ; obo:UBPROP_0000001 "A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG]" ; obo:UBPROP_0000003 "The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG]" ; obo:UBPROP_0000007 "ethmoidal" ; obo:UBPROP_0000008 "todo - homology e.g. mesethmoid of teleost" ; obo:UBPROP_0000012 "Note the WP states the Neurocranium contains the ethmoid bone, both MA and FMA place the ethmoid as part of the viscerocranium. FMA also has it in neurocranium (via basicranium). Ideally we would have non-overlapping divisions of the skull, but for now we follow FMA" ; oboInOwl:hasDbXref "BTO:0004140", "EMAPA:19018", "FMA:52740", "GAID:212", "MA:0001483", "MESH:D005004", "NCIT:C12711", "SCTID:272674006", "UMLS:C0015027", "VHOG:0001317", "Wikipedia:Ethmoid_bone" ; oboInOwl:hasExactSynonym "ethmoid", "ethmoidal bone", "os ethmoidale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001679" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ethmoid bone" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011241 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid118893 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg"^^xsd:anyURI . obo:UBERON_0001680 obo:IAO_0000115 "The irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla." ; obo:UBPROP_0000003 "The infraorbital bone 1 of actinopterygians is homologous with the lacrimal bone (...).[well established][VHOG]" ; obo:UBPROP_0000008 "In early lobe-finned fishes and ancestral tetrapods, the lacrimal bone is a relatively large and robust bone, running from the orbit to the nostrils. It forms part of the side of the face, between the nasal bones and the maxilla. In primitive forms, it is often accompanied by a much smaller septomaxilla bone, lying immediately behind the nasal opening, but this is lost in most modern species. The lacrimal bone is often smaller in living vertebrates, and is no longer always directly associated with the nasal opening, although it retains its connection with the orbit. The bone is entirely absent in living amphibians, as well as some reptilian species[ISBN 0-03-910284-X]" ; oboInOwl:hasBroadSynonym "lacrimal" ; oboInOwl:hasDbXref "FMA:52741", "MA:0001486", "NCIT:C32906", "SCTID:272675007", "UMLS:C0222733", "VHOG:0001149", "Wikipedia:Lacrimal_bone" ; oboInOwl:hasExactSynonym "lachrymal bone", "lacrymal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "infraorbital 1", "lachrymal bone - infraorbital 1", "lacrimal - infraorbital 1", "lacrymal bone - infraorbital 1", "os lacrimale" ; oboInOwl:id "UBERON:0001680" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lacrimal bone" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_7500102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid118905, _:genid118909, _:genid118911 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png"^^xsd:anyURI . obo:UBERON_0001681 obo:IAO_0000115 "One of two small oblong bones, varying in size and form in different individuals; they are placed side by side at the middle and upper part of the face, and form, by their junction, 'the bridge' of the nose[WP]. Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish[ZFA]." ; obo:UBPROP_0000001 "Paired bone of intramembranous origin that roofs the olfactory capsule.[AAO]", "Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish Cubbage and Mabee, 1996.[TAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps mesethmoid-nasal joint (TAO:0001677)[TAO]", "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]" ; obo:UBPROP_0000005 "Synonym adnasal used in Weitzman 1960, and synonym discussed in Vari 1995.[TAO]" ; obo:UBPROP_0000008 "In primitive bony fish and tetrapods, the nasal bones are the most anterior of a set of four paired bones forming the roof of the skull, being followed in sequence by the frontals, the parietals, and the postparietals. Their form in living species is highly variable, depending on the shape of the head, but they generally form the roof of the snout or beak, running from the nostrils to a position short of the orbits. In most animals, they are generally therefore proportionally larger than in humans or great apes, because of the shortened faces of the latter. Turtles, unusually, lack nasal bones, with the prefrontal bones of the orbit reaching all the way to the nostrils (ISBN 0-03-910284-X)" ; oboInOwl:hasDbXref "AAO:0000312", "EMAPA:19202", "FMA:52745", "GAID:222", "MA:0001494", "MESH:D009295", "NCIT:C33157", "SCTID:181801008", "TAO:0000365", "UMLS:C0027422", "VHOG:0001370", "Wikipedia:Nasal_bone", "ZFA:0000365" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal bones", "nasals", "os nasale" ; oboInOwl:id "UBERON:0001681" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nasal bone" ; rdfs:subClassOf obo:UBERON_0002514, obo:UBERON_0010428, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid118924, _:genid118927 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg"^^xsd:anyURI . obo:UBERON_0001682 obo:IAO_0000115 "A paired dermal bone situated in the mid-palate that helps form the hard palate [Palaeos]." ; obo:RO_0002161 obo:NCBITaxon_32519 ; obo:UBPROP_0000001 "Dermal bone that forms the antero-lateral region of the palate and is located ventral to the autopalatine. The dermopalatine is bilaterally paired and usually bears teeth.[TAO]" ; obo:UBPROP_0000005 "Dermopalatine: same as palatine. The prefix is used by fish people because the palatine is a dermal replacement bone for a section of the autopalatine section of the palatoquadrate. In that context, palatine is potentially ambiguous.[Palaeos]", "In ostariophysans, the dermopalatine is absent.[TAO]" ; obo:UBPROP_0000008 "Fusion of dermopalatine+autopalatine." ; oboInOwl:hasDbXref "EMAPA:36619", "FMA:52746", "MA:0001495", "NCIT:C52745", "SCTID:244654005", "TAO:0000015", "UMLS:C0222734", "Wikipedia:Palatine_bone", "http://palaeos.com/vertebrates/bones/dermal/images/289x311xPalatine1.gif.pagespeed.ic.tglmNBrF4D.png" ; oboInOwl:hasExactSynonym "palatine" ; oboInOwl:hasNarrowSynonym "dermopalatine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os palatinum", "palate bone", "palatum" ; oboInOwl:id "UBERON:0001682" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "palatine bone" ; rdfs:subClassOf obo:UBERON_0008001, obo:UBERON_0008907, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011085 ], _:genid118422, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002397 ], _:genid118424, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid118944, _:genid118946, _:genid118948 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/44/Gray996.png"^^xsd:anyURI . obo:UBERON_0001683 obo:IAO_0000115 "The quadrilateral bone that forms the prominence of the cheek." ; obo:UBPROP_0000001 "The jugal is a skull bone found in most reptiles, amphibians, and birds. In mammals, the jugal is often called the malar or Zygomatic. It is connected to the quadratojugal and maxilla, as well as other bones, which may vary by species. This bone is considered key in the determination of general traits of the skull, in the case of creatures, as with dinosaurs in paleontology, whose entire skull has not been found[Wikipedia:Jugal_bone].", "The zygomatic bone is a paired dermal bone which articulates with the maxilla. In humans it also articulates with the temporal bone, the sphenoid bone and the frontal bone. The zygomatic is homologous to the jugal bone of other tetrapods. It is situated at the upper and lateral part of the face and forms the prominence of the cheek, part of the lateral wall and floor of the orbit, and parts of the temporal and infratemporal fossae. It presents a malar and a temporal surface; four processes, the frontosphenoidal, orbital, maxillary, and temporal; and four borders[WP,modified][Wikipedia:Zygomatic_bone]." ; obo:UBPROP_0000003 "(...) and the infraorbital bone 3 of advanced actinopterygians (is homologous) with the jugal bone of sarcopterygians.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans it also articulates with the temporal bone, the sphenoid bone and the frontal bone. The zygomatic is homologous to the jugal bone of other tetrapods. It is situated at the upper and lateral part of the face and forms the prominence of the cheek, part of the lateral wall and floor of the orbit, and parts of the temporal and infratemporal fossae. It presents a malar and a temporal surface; four processes, the frontosphenoidal, orbital, maxillary, and temporal; and four borders [Wikipedia:Zygomatic_bone, Wikipedia:Jugal_bone]", "vHOG says is homologous to infraorbital 3." ; oboInOwl:hasDbXref "EMAPA:25111", "FMA:52747", "GAID:225", "MA:0001497", "MFMO:0000146", "SCTID:272683001", "VHOG:0001638", "Wikipedia:Jugal_bone" ; oboInOwl:hasExactSynonym "cheek bone", "malar bone", "orbital bone", "os zygomaticum", "zygomatic bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "jugal", "jugal bone", "jugale", "os zygomaticum", "os zygomaticus", "zygoma", "zygomatic" ; oboInOwl:id "UBERON:0001683" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "jugal bone" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ], _:genid118442, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_7500102 ], _:genid118444, _:genid118965, _:genid118969, _:genid118971 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png"^^xsd:anyURI . obo:UBERON_0001684 obo:IAO_0000115 "A dentary bone that is the only bone in one of the lateral halves of the lower jaw skeleton." ; obo:IAO_0000116 "consider merging with dentary - for now we make it a mammal-specific subclass." ; obo:UBPROP_0000007 "mandibular" ; obo:UBPROP_0000012 "Note in ZFA 'mandible' is a syn for the ventral mandibular arch, which is a portion of the 1st pharyngeal arch; however the term 'mandibular symphysis' refers to the dentary" ; obo:UBPROP_0000013 "'mandible' also refers to either the upper OR lower part of the beak in birds" ; oboInOwl:hasBroadSynonym "lower jaw", "lower jaw bone" ; oboInOwl:hasDbXref "BTO:0001748", "CALOHA:TS-2225", "EFO:0001965", "EHDAA2:0001059", "EHDAA:8007", "EMAPA:18290", "FMA:52748", "GAID:68", "MA:0001487", "MESH:D008334", "NCIT:C12290", "SCTID:181812008", "UMLS:C0024687", "Wikipedia:Human_mandible", "galen:Mandible" ; oboInOwl:hasExactSynonym "inferior maxillary bone", "mammaliam mandible", "mandibulla" ; oboInOwl:hasNarrowSynonym "lower mandibula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibula", "mandibular series" ; oboInOwl:id "UBERON:0001684" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mandible" ; rdfs:subClassOf obo:UBERON_0002514, obo:UBERON_0004742, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001708 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png"^^xsd:anyURI . obo:UBERON_0001685 obo:IAO_0000115 "A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified]." ; obo:UBPROP_0000001 "Paired processes that extend posterolaterally from the posterior margin of the hyoid plate. These processes are the ossified posteromedial processes and invest the laryngeal apparatus.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of hyoid plate (AAO:0000664)[AAO]" ; obo:UBPROP_0000008 "The hyoid bone is derived from the lower half of the second gill arch in fish, which separates the first gill slit from the spiracle. In many animals, it also incorporates elements of other gill arches, and has a correspondingly greater number of cornua. Amphibians and reptiles may have many cornua, while mammals (including humans) have two pairs, and birds only one. In birds, and some reptiles, the body of the hyoid is greatly extended forward, creating a solid bony support for the tongue. The howler monkey Alouatta has a pneumatized hyoid bone, one of the few cases of postcranial pneumatization of bones outside Saurischia." ; oboInOwl:hasDbXref "AAO:0000684", "EMAPA:18650", "FMA:52749", "GAID:197", "MA:0001484", "MESH:D006928", "NCIT:C32752", "SCTID:263352000", "UMLS:C0020417", "VHOG:0001325", "Wikipedia:Hyoid_bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hyoid", "hyoid bone", "hyoideum", "lingual bone", "os hyoideum" ; oboInOwl:id "UBERON:0001685" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hyoid bone" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010272 ], _:genid119000, _:genid119002 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Gray186.png"^^xsd:anyURI . obo:UBERON_0001686 obo:IAO_0000115 "One of 3 small bones contained within the middle ear space and serve to transmit sounds from the air to the fluid-filled labyrinth. The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term 'ossicles' literally means 'tiny bones' and commonly refers to the auditory ossicles, though the term may refer to any small bone throughout the body. [WP,unvetted]." ; obo:IAO_0000116 "This should probably be restricted to mammals - the AAO/XAO structures may group non-homologous structures [Wikipedia:Evolution_of_mammalian_auditory_ossicles] see https://github.com/seger/aao/issues/5." ; obo:UBPROP_0000001 "The small bones of the middle ear: incus, malleus, and stapes. [TFD][VHOG]" ; obo:UBPROP_0000003 "Additional structural analysis within a phylogenetic context has led to the remarkable discovery that in synapsids, thought to be ancestral to mammals, both the quadrate and articular have become reduced and less firmly articulated with their surrounding bones, reducing their jaw-joint-bearing role. This trend culminated with the incorporation of the quadrate, the columella (which remains articulated with the quadrate), and the articular into the expanded middle ear in mammals.[well established][VHOG]" ; obo:UBPROP_0000011 "Studies have shown that ear bones in mammal embryos are attached to the dentary, which is part of the jaw. These are ossified portions of cartilage -- called Meckel's cartilage -- that are attached to the jaw. As the embryo develops, the cartilage hardens to form bone. Later in development, the bone structure breaks loose from the jaw and migrates to the inner ear area. The structure is known as the middle ear, and is made up of the incus, stapes, malleus, and tympanic membrane. These correspond to the quadrate, prearticular, articular, and angular structures in the reptile jaw. For this reason, researchers believe the similarity of the results shows that mammals and reptiles have a common ancestry." ; oboInOwl:hasBroadSynonym "ossicle" ; oboInOwl:hasDbXref "AAO:0011015", "EHDAA2:0001183", "EHDAA:5697", "EMAPA:17824", "EV:0100360", "FMA:52750", "MA:0000254", "NCIT:C32164", "SCTID:181184001", "UMLS:C0013450", "VHOG:0000461", "Wikipedia:Auditory_ossicle", "XAO:0000214" ; oboInOwl:hasExactSynonym "auditory bone", "middle ear ossicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory ossicle", "ear bone", "ear ossicle", "ear ossicles", "middle ear bone", "ossicle of ear", "ossicle of inner ear", "ossicular chain" ; oboInOwl:id "UBERON:0001686" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "auditory ossicle bone" ; rdfs:subClassOf _:genid119018, _:genid119020, _:genid119022 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035130 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b0/Illu_auditory_ossicles.jpg"^^xsd:anyURI . obo:UBERON_0001687 obo:IAO_0000115 "The stapes or stirrup is the stirrup-shaped small bone or ossicle in the middle ear which is attached to the incus laterally and to the fenestra ovalis, the 'oval window' medially. The oval window is adjacent to the vestibule of the inner ear. The stapes is the smallest and lightest bone in the human body. The stapes transmits the sound vibrations from the incus to the membrane of the inner ear inside the fenestra ovalis. The stapes is also stabilized by the stapedius muscle, which is innervated by the facial nerve. In non-mammalian vertebrates, the bone homologous to the stapes is usually called the columella; however, in reptiles, either term may be used[WP,unvetted]." ; obo:UBPROP_0000003 "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" ; obo:UBPROP_0000008 "'This structure [the hyomandibular], on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.' Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948) 62:339-357?[VHOG]." ; obo:UBPROP_0000011 "As the stapes first develops embryologically from the 6th to 8th week of life, it surrounds the stapedial artery, which supplies the majority of the vasculature of the embryonic head. After that period, the external carotid artery is generated and takes over for the stapedial artery, which subsequently involutes, leaving the stapes with a windowframe-like structure[WP] The stapes develops at the cranial end of the second branchial arch through an independent anlage of the cartilage of this arch. Between the stapedial anlage and the cranial end of the Reichert's cartilage there is a formation called the interhyale, the internal segment of which gives rise to the tendon of the stapedial muscle. The stapedial anlage is a unique formation with two distinct parts: the superior part that will comprise the base and the inferior part that will be crossed by the stapedial artery during embryonic development and will constitute the limbs and the head of the stapes. According to the results, the otic capsule is not involved in formation of the base of the stapes." ; oboInOwl:hasDbXref "EMAPA:18585", "FMA:52751", "GAID:868", "MA:0001217", "MESH:D013199", "NCIT:C33612", "SCTID:264199009", "UMLS:C0038152", "VHOG:0000688", "Wikipedia:Stapes" ; oboInOwl:hasExactSynonym "stirrup" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columella", "columella auris", "columellare", "interstapediale", "mediostapediale", "mesostapediale", "os columellare", "os intermedium", "stapellos", "stapes", "stelidium", "stilus columellare" ; oboInOwl:id "UBERON:0001687" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "stapes bone" ; rdfs:subClassOf _:genid119039, _:genid119041 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid118506 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c1/Gray918.png"^^xsd:anyURI . obo:UBERON_0001688 obo:IAO_0000115 "The incus or anvil is the anvil-shaped small bone or ossicle in the middle ear. It connects the malleus to the stapes. It was first described by Alessandro Achillin of Bologna. The incus transmits sound vibrations from the malleus to the stapes. The incus only exists in mammals, and is derived from a reptilian upper jaw bone, the quadrate bone. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted]." ; obo:UBPROP_0000003 "According to this theory (Reichert-Gaupp theory), the mammalian stapes is derived from the reptilian columella, the incus from the quadrate and the malleus from the articular (...).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "quadrate - incus" ; oboInOwl:hasDbXref "EMAPA:18583", "FMA:52752", "GAID:866", "MA:0001215", "MESH:D007188", "NCIT:C32770", "SCTID:272649008", "UMLS:C0021181", "VHOG:0000689", "Wikipedia:Incus" ; oboInOwl:hasExactSynonym "incus", "incus bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001688" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "incus bone" ; rdfs:subClassOf _:genid119063 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015017 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray917.png"^^xsd:anyURI . obo:UBERON_0001689 obo:IAO_0000115 "The malleus or hammer is a hammer-shaped small bone or ossicle of the middle ear which connects with the incus and is attached to the inner surface of the eardrum. The word is Latin for hammer. It transmits the sound vibrations from the eardrum to the incus. The malleus is unique to mammals, and evolved from a lower jaw bone in basal amniotes called the articular, which still forms part of the jaw joint in reptiles. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted]." ; obo:UBPROP_0000003 "According to this theory (Reichert-Gaupp theory), the mammalian stapes is derived from the reptilian columella, the incus from the quadrate and the malleus from the articular (...).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "anguloarticular - malleus", "malleus" ; oboInOwl:hasDbXref "EMAPA:18584", "FMA:52753", "GAID:867", "MA:0001216", "MESH:D008307", "NCIT:C33051", "SCTID:264090005", "UMLS:C0024631", "VHOG:0000690", "Wikipedia:Malleus" ; oboInOwl:hasExactSynonym "malleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001689" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "malleus bone" ; rdfs:subClassOf _:genid119074, _:genid119076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015018 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray916.png"^^xsd:anyURI . obo:UBERON_0001690 obo:IAO_0000115 "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." ; obo:UBPROP_0000001 "The organ of hearing and of equilibrium. [TFD][VHOG]" ; obo:UBPROP_0000003 "Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG]" ; obo:UBPROP_0000007 "auricular" ; oboInOwl:hasDbXref "AAO:0011014", "BIRNLEX:1062", "BTO:0000368", "CALOHA:TS-1165", "EFO:0000826", "EHDAA2:0000423", "EHDAA:502", "EMAPA:16193", "EV:0100353", "FMA:52780", "GAID:62", "MA:0000236", "MAT:0000138", "MESH:D004423", "MIAA:0000138", "NCIT:C12394", "SCTID:1910005", "UMLS:C0013443", "UMLS:C0521421", "VHOG:0000330", "Wikipedia:Ear", "XAO:0000189", "galen:Ear" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory apparatus", "auris" ; oboInOwl:id "UBERON:0001690" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ear" ; rdfs:subClassOf obo:UBERON_0000020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050910 ], _:genid119087 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Ear.jpg"^^xsd:anyURI . obo:UBERON_0001691 obo:IAO_0000115 "Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO]." ; obo:RO_0002161 obo:NCBITaxon_9709 ; obo:UBPROP_0000001 "The external part of the organ, which consists of an outer portion (external auditory meatus) which leads to the tympanum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "Some species, like Amolops tormotus (Feng et al. 2006), have a cavity in front of the tympanic membrane which is considered to be an ear canal and thus an outer ear. (...) The ancestral lineage of amphibians separated from the mammalian lineage, approximately 350 million years ago, in the paleozoic era. Many of the important developments in the auditory systems emerged after the ancestral paths separated (Manley and Clack 2003). This implies that shared features, like the tympanic middle ear, developed independently in different vertebrate lineages.[uncertain][VHOG]" ; obo:UBPROP_0000012 "in XAO this includes and is only the tympanum" ; oboInOwl:hasBroadSynonym "auricular region" ; oboInOwl:hasDbXref "AAO:0011037", "BIRNLEX:1705", "BTO:0002100", "EFO:0004221", "EHDAA2:0000462", "EHDAA:3786", "EMAPA:16991", "EV:0100354", "FMA:52781", "GAID:104", "MA:0000258", "MAT:0000147", "MESH:D004431", "MIAA:0000147", "NCIT:C12292", "SCTID:420893000", "UMLS:C0013453", "UMLS:C1269548", "VHOG:0000311", "Wikipedia:External_ear", "XAO:0000190" ; oboInOwl:hasExactSynonym "auricular region of head", "outer ear" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auris externa" ; oboInOwl:id "UBERON:0001691" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "external ear" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001690 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray907.png"^^xsd:anyURI . obo:UBERON_0001694 obo:IAO_0000115 "The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted]." ; obo:UBPROP_0000001 "The petrosal bone arises from the two otic bones on the lateral wall of the chondrocranium and encases the inner ear of mammals. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.258, see_Liem_KF][VHOG]" ; obo:UBPROP_0000008 "derivative of prootic and opisthotic" ; oboInOwl:hasBroadSynonym "petrosal" ; oboInOwl:hasDbXref "EHDAA2:0001452", "EMAPA:17683", "FMA:52871", "GAID:234", "MA:0001477", "MESH:D010579", "NCIT:C32316", "SCTID:361733004", "UMLS:C1261761", "VHOG:0001553", "Wikipedia:Petrous_part_of_the_temporal_bone" ; oboInOwl:hasExactSynonym "pars petrosa (os temporale)", "pars petrosa ossis temporalis", "petromastoid part of temporal bone", "temporal bone petrous part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "petrosal bone", "petrous bone" ; oboInOwl:id "UBERON:0001694" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "petrous part of temporal bone" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 ], _:genid119109 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray137.png"^^xsd:anyURI . obo:UBERON_0001695 obo:IAO_0000115 "A bone which is fused with the temporal bone in many mammals and forms part of the cheek region articulating with quadrate and pterygoid in other vertebrates." ; obo:IAO_0000116 "consider separate class for squamosal OR making squamosal the primary label" ; obo:UBPROP_0000001 "Paired, intramembranous bones that lie at the posterolateral margins of the skull. Lateral and dorsal to the quadrate.[AAO]", "The squamosal bone is part of the dermatocranium in early tetrapods and becomes part of the mammalian occipital and temporal bones. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.246, see_Liem_KF][VHOG]" ; obo:UBPROP_0000008 "The squamosal bone, which is homologous with the squama, and forms the side of the cranium in many bony fish and tetrapods. Primitively, it is a flattened plate-like bone, but in many animals it is narrower in form, for example, where it forms the boundary between the two temporal fenestrae of diapsid reptiles" ; oboInOwl:hasDbXref "AAO:0000574", "EMAPA:18021", "FMA:52883", "MA:0001473", "SCTID:138672006", "VHOG:0001561", "Wikipedia:Squamosal_bone" ; oboInOwl:hasExactSynonym "os squamosum", "pars squamosa (os temporale)", "pars squamosa ossis temporalis", "squama temporalis", "squamosal", "squamosal bone", "squamosum", "squamous bone", "temporal bone squamous part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "squama" ; oboInOwl:id "UBERON:0001695" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "squamous part of temporal bone" ; rdfs:subClassOf obo:UBERON_0002514, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010751 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001678 ], _:genid119120, _:genid119122, _:genid119124 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Skull_synapsida_1.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/f/fd/Gray144.png"^^xsd:anyURI . obo:UBERON_0001697 obo:IAO_0000115 "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." ; obo:UBPROP_0000001 "Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO]" ; obo:UBPROP_0000012 "in FMA, this overlaps with bones such as the maxilla and sphenoid; in ZFA, individual bones are part of the orbit" ; oboInOwl:hasDbXref "BTO:0004687", "FMA:53074", "GAID:223", "MA:0002482", "MESH:D009915", "NCIT:C12347", "TAO:0001410", "UMLS:C0029180", "Wikipedia:Orbit_(anatomy)", "XAO:0003171", "ZFA:0001410", "galen:Orbit" ; oboInOwl:hasExactSynonym "bony orbit", "eye socket", "orbit of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "orbit" ; oboInOwl:id "UBERON:0001697" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "orbit of skull" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid119140 . obo:UBERON_0001700 obo:IAO_0000115 "The group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)." ; obo:IAO_0000116 "resolve facial VII vs geniculate (see EHDAA2)" ; obo:UBPROP_0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "geniculate" ; oboInOwl:hasDbXref "BAMS:GgVII", "EFO:0003669", "EHDAA2:0000491", "EHDAA2:0004623", "EHDAA:5567", "EHDAA:6644", "EMAPA:17569", "FMA:53414", "GAID:718", "MA:0001076", "MESH:D005830", "NCIT:C12721", "SCTID:279076005", "TAO:0001291", "UMLS:C0017406", "VHOG:0000707", "Wikipedia:Geniculate_ganglion", "ZFA:0001291", "neuronames:1535" ; oboInOwl:hasExactSynonym "facial VII ganglion", "gVII", "ganglion genicularum", "genicular ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial ganglion", "ganglion geniculi", "ganglion geniculi nervi facialis", "geniculate ganglion", "internal genu" ; oboInOwl:id "UBERON:0001700" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "geniculate ganglion" ; rdfs:subClassOf obo:UBERON_0001800, _:genid119154, _:genid119156, _:genid119158, _:genid119160 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001647 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png"^^xsd:anyURI . obo:UBERON_0001701 obo:IAO_0000115 "The group of neuron cell bodies associated with the ninth cranial nerve." ; obo:UBPROP_0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000710", "EHDAA:2838", "EMAPA:16795", "FMA:53471", "MA:0001077", "SCTID:244451008", "TAO:0001301", "VHOG:0000702", "ZFA:0001301" ; oboInOwl:hasExactSynonym "ganglion of glossopharyngeal nerve", "ganglion of glosspharyngeal nerve", "glossopharyngeal IX ganglion" ; oboInOwl:hasNarrowSynonym "petrosal ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gIX" ; oboInOwl:id "UBERON:0001701" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "glossopharyngeal ganglion" ; rdfs:subClassOf obo:UBERON_0009127, _:genid119180, _:genid119182 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001649 ] ) ] . obo:UBERON_0001702 obo:IAO_0000115 "Any of the hairs that grow at the edge of the upper or lower eyelid." ; obo:UBPROP_0000009 "eyelashes protect the eye from debris and are sensitive to touch, thus providing a warning that an object is near the eye (which is then closed reflexively)" ; obo:UBPROP_0000202 obo:FMA_70742 ; oboInOwl:hasDbXref "FMA:53669", "GAID:73", "MA:0002702", "MESH:D005140", "NCIT:C32576", "SCTID:244201001", "UMLS:C0015422", "Wikipedia:Eyelash" ; oboInOwl:hasExactSynonym "eyelid cilium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blepharis", "cilia", "cilium", "eyelid cilia", "hair of eyelid" ; oboInOwl:id "UBERON:0001702" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "eyelash" ; rdfs:subClassOf obo:UBERON_0001037, [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001711 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/N2_Human_eye.jpg"^^xsd:anyURI . obo:UBERON_0001703 obo:IAO_0000115 "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." ; obo:UBPROP_0000001 "Anatomical cluster that consists of the cartilages and bones that surround the brain.[TAO]" ; obo:UBPROP_0000007 "neurocranial" ; obo:UBPROP_0000010 "It includes the following bones: Ethmoid bone, Frontal bone, Occipital bone, Parietal bone, Sphenoid bone, Temporal bone. The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton" ; obo:UBPROP_0000011 "The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]." ; obo:UBPROP_0000012 "It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ..." ; oboInOwl:hasDbXref "AAO:0010153", "EHDAA2:0000243", "EMAPA:17681", "FMA:53672", "MA:0000317", "SCTID:361731002", "TAO:0001580", "Wikipedia:Neuroranium", "XAO:0003170", "ZFA:0001580" ; oboInOwl:hasExactSynonym "brain box" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain case", "brain pan", "braincase" ; oboInOwl:id "UBERON:0001703" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neurocranium" ; rdfs:subClassOf obo:UBERON_0011158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004761 ], [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:UBERON_0001705 obo:IAO_0000115 "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]." ; obo:IAO_0000232 "Use this class for both the nails of primates and the homologous claws of mammals such as mouse." ; obo:UBPROP_0000008 "A primate's nail consists of the unguis alone; the subunguis has disappeared" ; oboInOwl:hasDbXref "BTO:0001719", "CALOHA:TS-2034", "EFO:0000956", "EMAPA:35580", "EV:0100159", "FMA:54326", "GAID:1320", "MA:0002703", "MAT:0000158", "MESH:D009262", "MIAA:0000158", "NCIT:C33156", "SCTID:72651009", "UMLS:C0027342", "VHOG:0001361", "Wikipedia:Nail_(anatomy)", "galen:Nail" ; oboInOwl:hasExactSynonym "nail/claw" ; oboInOwl:hasNarrowSynonym "claw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "talon" ; oboInOwl:id "UBERON:0001705" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226]" ; rdfs:label "nail" ; rdfs:subClassOf obo:UBERON_0009564, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0045095 ], _:genid119207, _:genid119209 . obo:UBERON_0001706 obo:IAO_0000115 "The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted]." ; obo:IAO_0000116 "We follow AAO in making this part of the nasal skeleton" ; obo:UBPROP_0000001 "A median dividing wall, sagittally directed, which divides the nasal cavity into the right and the left nasal fossae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]", "Medial vertical wall between nasal capsules.[AAO]", "Medial, vertical plate that separates the nasal capsules.[AAO]" ; obo:UBPROP_0000003 "Whatever the common ancestor of the lamprey and gnathostomes may have looked like, it most likely possessed a neural-crest-derived premandibular ectomesenchyme closely associated with the NHP. Invention of the jaw subsequently required a space for the nasal septum and maxillary process to develop, which might have been provided by subdivision of the NHP into the nasal placode and the hypophysis (diplorhiny, the state of bilaterally separated nasal openings, would also have been a prerequisite for this).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000559", "AAO:0010135", "EHDAA2:0001234", "EHDAA2:0004104", "EHDAA:6809", "EMAPA:17608", "FMA:54375", "GAID:115", "MA:0000285", "MESH:D009300", "NCIT:C33160", "SCTID:181197004", "UMLS:C0027432", "VHOG:0000017", "Wikipedia:Nasal_septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "septal cartilage", "septum mobile nasi", "septum nasi", "septum of the nose" ; oboInOwl:id "UBERON:0001706" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "nasal septum" ; rdfs:subClassOf obo:UBERON_0003037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000004 ], _:genid119217, _:genid119219, _:genid119221 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray854.png"^^xsd:anyURI . obo:UBERON_0001707 obo:IAO_0000115 "An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." ; obo:IAO_0000116 "define the boundaries of this cavity for a variety of species and check that parthood relations are not too strong." ; obo:UBPROP_0000001 "Saclike space internal to the nasal capsule lined by respiratory and sensory epithelium and glandular tissue.[AAO]", "a large air filled space above and behind the nose in the middle of the face[WP][Wikipedia:Nasal_cavity]." ; obo:UBPROP_0000003 "Despite significant modification to the nasal cavity within Archosauria and its extreme hypertrophy and supraorbital development in Lambeosaurinae, the neural olfactory system and the olfactory region of the nasal cavity proper retain their plesiomorphic positions and associations, suggesting that this system is highly conserved in vertebrate evolution.[well established][VHOG]" ; obo:UBPROP_0000008 "in humans, the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures" ; oboInOwl:hasDbXref "AAO:0000314", "BTO:0002096", "EHDAA2:0001226", "EHDAA:6801", "EMAPA:17604", "FMA:54378", "GAID:350", "MA:0000284", "MESH:D009296", "NCIT:C12424", "SCTID:263481003", "TAO:0000130", "UMLS:C0027423", "VHOG:0000271", "Wikipedia:Nasal_cavity", "ZFA:0000130" ; oboInOwl:hasExactSynonym "cavity of nose", "cavity of olfactory apparatus", "nasal canal", "nasal conduit space", "nasal fossa", "olfactory chamber cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas nasalis", "cavitas nasi", "cavum nasi", "nasal pit", "olfactory cavity", "olfactory chamber", "olfactory pit" ; oboInOwl:id "UBERON:0001707" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nasal cavity" ; rdfs:subClassOf obo:UBERON_0002553, _:genid118682, _:genid119234 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg"^^xsd:anyURI . obo:UBERON_0001708 obo:IAO_0000115 "Subdivision of skeleton which includes upper and lower jaw skeletons." ; obo:IAO_0000116 "TODO - move ZFA:0001227 (it is the entire jaw skeleton)." ; obo:UBPROP_0000001 "Skeletal and cartilage elements of the first pharyngeal arch.[TAO]" ; obo:UBPROP_0000011 "There are cellular contributions from all three embryonic germ layers: pharyngeal mesoderm, endoderm and neural crest that migrates out of the ectoderm (Noden, 1983)." ; obo:UBPROP_0000012 "in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates" ; oboInOwl:hasDbXref "AAO:0000988", "BTO:0001749", "EMAPA:35455", "FMA:54396", "GAID:214", "MA:0001905", "MESH:D007568", "NCIT:C48821", "SCTID:181811001", "TAO:0001227", "UMLS:C0022359", "Wikipedia:Jaw", "ZFA:0001227", "galen:Jaw" ; oboInOwl:hasExactSynonym "jaw", "jaw cartilage", "mandibular arch skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior splanchnocranium", "jaws", "mandibular arch", "oral jaw skeleton", "pharyngeal arch 1 skeleton", "visceral arch 1" ; oboInOwl:id "UBERON:0001708" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "jaw skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0008895 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:NBO_0000073 ], _:genid119257, _:genid119262 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0011595 ] ) ] . obo:UBERON_0001709 obo:IAO_0000115 "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." ; obo:RO_0002171 obo:UBERON_0001710 ; obo:UBPROP_0000001 "Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO]" ; obo:UBPROP_0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" ; obo:UBPROP_0000012 "Note isa/partof difference MA/FMA" ; oboInOwl:hasDbXref "AAO:0000620", "EHDAA2:0002118", "EHDAA2:0004607", "EHDAA:8025", "EMAPA:17924", "FMA:59399", "SCTID:362636001", "VHOG:0000454", "Wikipedia:Upper_jaw", "ncithesaurus:Upper_Jaw" ; oboInOwl:hasExactSynonym "maxillary part of mouth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alveolodental arch of bimaxilla", "dorsal mandibular arch", "dorsal pharyngeal arch 1", "maxillary part of mouth proper", "palatoquadrate arch", "upper pharyngeal jaws" ; oboInOwl:id "UBERON:0001709" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "See notes for jaw w.r.t skeletal element vs subdivision of head." ; rdfs:label "upper jaw region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004089 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ] ; owl:disjointWith obo:UBERON_0001710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0003277 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png"^^xsd:anyURI . obo:UBERON_0001710 obo:IAO_0000115 "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." ; obo:RO_0002171 obo:UBERON_0001709 ; obo:UBPROP_0000001 "Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO]" ; obo:UBPROP_0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" ; obo:UBPROP_0000012 "Note isa/partof difference MA/FMA" ; oboInOwl:hasDbXref "AAO:0000272", "EFO:0003660", "EHDAA2:0001018", "EHDAA:7995", "EMAPA:17906", "FMA:59398", "MESH:D008334", "SCTID:362637005", "VHOG:0000453", "Wikipedia:Lower_jaw", "ncithesaurus:Lower_Jaw" ; oboInOwl:hasExactSynonym "mandibular part of mouth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower part of mouth", "mandibular series" ; oboInOwl:id "UBERON:0001710" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "See notes for jaw w.r.t skeletal element vs subdivision of head" ; rdfs:label "lower jaw region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ], _:genid119292 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0003278 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png"^^xsd:anyURI . obo:UBERON_0001711 obo:IAO_0000115 "A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane." ; obo:UBPROP_0000007 "blepharic", "palpebral" ; obo:UBPROP_0000008 "In humans the upper and lower eyelid consists of the following layers, starting anteriorly: (1) skin, (2) a layer of subcutaneous connective tissue, (3) a layer of striated muscle fibres of the orbicularis muscle, (4) a layer of submuscular connective tissue, (5) a fibrous layer, including the tarsal plates, (6) a layer of smooth muscle, (7) the palpebral conjunctiva." ; obo:UBPROP_0000012 "Consider adding 'eye surface', like MA", "FMA divides this into skin, fascia, conjunctiva" ; obo:UBPROP_0000202 obo:FMA_75178 ; oboInOwl:hasDbXref "BTO:0002241", "EHDAA2:0000487", "EHDAA:9037", "EMAPA:17829", "EV:0100338", "FMA:54437", "GAID:72", "MA:0000268", "MESH:D005143", "NCIT:C12713", "SCTID:265782007", "UMLS:C0015426", "VHOG:0000016", "Wikipedia:Eyelid" ; oboInOwl:hasExactSynonym "blepharon", "eye lid", "palpebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blephara", "palpebrae" ; oboInOwl:id "UBERON:0001711" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "eyelid" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0060082 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0010409 ], _:genid119299 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg"^^xsd:anyURI . obo:UBERON_0001712 obo:UBPROP_0000003 "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0002115", "EHDAA:9047", "EMAPA:17834", "FMA:54439", "MA:0001267", "NCIT:C49581", "SCTID:244499008", "UMLS:C0585636", "VHOG:0000389" ; oboInOwl:hasExactSynonym "palpebra superior", "superior eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001712" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "upper eyelid" ; rdfs:subClassOf obo:UBERON_0001711 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg"^^xsd:anyURI . obo:UBERON_0001713 obo:UBPROP_0000003 "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010349", "EHDAA2:0001015", "EHDAA:9041", "EMAPA:17831", "FMA:54442", "MA:0001263", "NCIT:C49580", "SCTID:362528002", "UMLS:C0229258", "VHOG:0000388", "XAO:0000007" ; oboInOwl:hasExactSynonym "inferior eyelid", "palpebra inferior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001713" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lower eyelid" ; rdfs:subClassOf obo:UBERON_0001711 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg"^^xsd:anyURI . obo:UBERON_0001714 obo:IAO_0000115 "The groups of nerve cell bodies associated with the twelve cranial nerves." ; obo:UBPROP_0000001 "Ganglion which is located in the head.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0003213", "UBERON:0026601" ; oboInOwl:hasDbXref "BIRNLEX:2597", "BTO:0000106", "EFO:0000902", "EMAPA:16659", "FMA:54502", "MA:0000213", "MA:0000214", "MAT:0000200", "MIAA:0000200", "SCTID:244448001", "TAO:0000013", "VHOG:0000076", "Wikipedia:Cranial_nerve_ganglion", "XAO:0000027", "ZFA:0000013" ; oboInOwl:hasExactSynonym "cranial ganglion", "cranial ganglion part of peripheral nervous system", "cranial ganglion/nerve", "cranial nerve ganglion", "cranial neural ganglion", "cranial neural tree organ ganglion", "ganglion of cranial nerve", "ganglion of cranial neural tree organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial ganglia", "head ganglion", "presumptive cranial ganglia" ; oboInOwl:id "UBERON:0001714" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cranial ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0034713 ] ) ] . obo:UBERON_0001715 obo:IAO_0000115 "Nuclear complex containing subnuclei that give rise to the axons of the occulomotor nerve, both motor and parasympathetic fibers, situated at the midline at the level of the superior colliculus in the midbrain tegmentum (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533-534)." ; obo:RO_0002171 obo:UBERON_0001944, obo:UBERON_0001947, obo:UBERON_0001966, obo:UBERON_0002141, obo:UBERON_0002438, obo:UBERON_0002691, obo:UBERON_0002696, obo:UBERON_0002722, obo:UBERON_0002995, obo:UBERON_0003040 ; obo:UBPROP_0000001 "The nucleus of the oculomotor nerve (cranial nerve III)[XAO:0004389]." ; obo:UBPROP_0000202 obo:FMA_84019 ; oboInOwl:hasDbXref "BAMS:3", "BAMS:III", "BIRNLEX:1240", "BM:MB-III", "DHBA:12198", "EFO:0002468", "EHDAA2:0004211", "EMAPA:35605", "EV:0100250", "FMA:54510", "HBA:9030", "MA:0001073", "MBA:35", "MESH:D065838", "NCIT:C12897", "SCTID:362457000", "TAO:0000553", "UMLS:C0228686", "VHOG:0001389", "Wikipedia:Nucleus_of_oculomotor_nerve", "XAO:0004389", "ZFA:0000553", "neuronames:492" ; oboInOwl:hasExactSynonym "OM", "nucleus nervi oculomotorii", "nucleus of oculomotor nerve", "nucleus of oculomotor nuclear complex", "nucleus of third cranial nerve", "oculomotor III nuclear complex", "oculomotor III nucleus", "oculomotor nucleus", "third cranial nerve nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "motor nucleus III", "nIII", "nucleus oculomotorius", "oculomotor motornucleus" ; oboInOwl:id "UBERON:0001715" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "oculomotor nuclear complex" ; rdfs:subClassOf obo:UBERON_0007245, _:genid119329 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Cn3nucleus.png"^^xsd:anyURI . obo:UBERON_0001716 obo:IAO_0000115 "The part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences." ; obo:UBPROP_0000007 "palatal" ; obo:UBPROP_0000008 "present in mammals and some reptiles. A similar structure is found in crocodilians, but, in most other tetrapods, the oral and nasal cavities are not truly separate. The secondary palate is formed by bilateral medial extensions of maxillary processes. The extensions (palatine processes) meet at the midline, merging dorsally with nasal septum and rostrally with primary palate. The secondary palate (hard palate) separates nasal and oral cavities. Caudal extension of the secondary palate into the pharynx, forms a soft palate which divides the rostral pharynx into dorsal (nasopharynx) and ventral (oropharynx) chamber." ; obo:UBPROP_0000009 "separates respiratory and oral passages" ; oboInOwl:hasBroadSynonym "palate", "palatum" ; oboInOwl:hasDbXref "BTO:0001779", "EMAPA:18948", "FMA:54549", "GAID:152", "MA:0002476", "MESH:D010159", "NCIT:C12229", "NCIT:C34292", "SCTID:181227004", "UMLS:C0700374", "UMLS:C1519217", "Wikipedia:Secondary_palate", "galen:Palate" ; oboInOwl:hasExactSynonym "definitive palate", "oral roof", "palatum definitivum", "palatum secundarium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palatum", "roof of mouth" ; oboInOwl:id "UBERON:0001716" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "secondary palate" ; rdfs:subClassOf obo:UBERON_0007375, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001707 ], _:genid119355, _:genid119357, _:genid119359 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Pig_snout_sagittal_cut.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg"^^xsd:anyURI . obo:UBERON_0001720 obo:IAO_0000115 "Any of the nuclei of the cochlear nuclear complex." ; oboInOwl:hasDbXref "EMAPA:35248", "FMA:54603", "GAID:601", "MA:0001012", "MESH:D017626", "NCIT:C12837", "SCTID:362463009", "TAO:0002243", "Wikipedia:Cochlear_nucleus", "ZFA:0001638" ; oboInOwl:hasExactSynonym "cochlear VIII nucleus", "cochlear nucleus of acoustic nerve", "cochlear nucleus of eighth cranial nerve", "nucleus of cochlear nerve", "statoacoustic (VIII) nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vestibulocochlear nucleus" ; oboInOwl:id "UBERON:0001720" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cochlear nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002298 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0004727 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002610 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png"^^xsd:anyURI . obo:UBERON_0001723 obo:IAO_0000115 "A muscular organ in the floor of the mouth." ; obo:IAO_0000116 "in MA the tongue is part of the oral region, which in uberon is treated as the oral opening. consider revising oral opening - oral region equivalence." ; obo:UBPROP_0000001 "A mobile mass of muscular tissue that is covered with mucous membrane, occupies much of the cavity of the mouth, forms part of its floor, bears the organ of taste, and assists in chewing and swallowing. [TFD][VHOG]", "Muscular organ in the floor of the mouth.[FEED]", "The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech[GO][GO:0043586]." ; obo:UBPROP_0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" ; obo:UBPROP_0000007 "glossal", "lingual" ; obo:UBPROP_0000008 "Many species of fish have small folds at the base of their mouths that might informally be called tongues, but they lack a muscular structure like the true tongues found in most tetrapods" ; obo:UBPROP_0000011 "The tongue has contributions from all pharyngeal arches which changes with time. The tongue initially begins as swelling rostral to foramen cecum, the median tongue bud.. tongue muscles derive from the somites - http://php.med.unsw.edu.au/embryology/index.php?title=Tongue_Development#Pharyngeal_Arch_Contributions" ; oboInOwl:hasDbXref "AAO:0010360", "BTO:0001385", "CALOHA:TS-1050", "EFO:0000833", "EHDAA2:0002062", "EHDAA:9144", "EMAPA:17185", "EV:0100058", "FMA:54640", "GAID:816", "MA:0000347", "MAT:0000040", "MESH:D014059", "MIAA:0000040", "NCIT:C12422", "SCTID:181226008", "TAO:0005333", "UMLS:C0040408", "VHOG:0000419", "Wikipedia:Tongue", "XAO:0000446", "ZFA:0005333" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glossus" ; oboInOwl:id "UBERON:0001723" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "tongue" ; rdfs:subClassOf obo:UBERON_0000020, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008814 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000166 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001007 ], _:genid119380, _:genid119382, _:genid119386, _:genid119388, _:genid119390, _:genid119393 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Tongue.agr.jpg"^^xsd:anyURI . obo:UBERON_0001724 obo:IAO_0000115 "One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side[MESH]. The sphenoidal sinuses (or sphenoid) contained within the body of the sphenoid vary in size and shape; owing to the lateral displacement of the intervening septum they are rarely symmetrical. The following are their average measurements: vertical height, 2.2 cm. ; transverse breadth, 2 cm. ; antero-posterior depth, 2.2 cm. [WP,unvetted]." ; oboInOwl:hasDbXref "FMA:54683", "GAID:359", "MA:0001795", "MESH:D013101", "NCIT:C12278", "SCTID:181207000", "UMLS:C0037885", "Wikipedia:Sphenoidal_sinus" ; oboInOwl:hasExactSynonym "sphenoid sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinus sphenoidalis" ; oboInOwl:id "UBERON:0001724" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sphenoidal sinus" ; rdfs:subClassOf _:genid118839, _:genid119407 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001825 _:genid118837 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray856.png"^^xsd:anyURI . obo:UBERON_0001725 obo:IAO_0000115 "The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis." ; oboInOwl:hasDbXref "EMAPA:35264", "FMA:54816", "MA:0001502", "SCTID:314228003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001725" ; a owl:Class ; rdfs:label "cranial synchondrosis" ; rdfs:subClassOf obo:UBERON_0002215 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid118845 ] . obo:UBERON_0001726 oboInOwl:hasDbXref "BIRNLEX:4102", "EMAPA:32777", "FMA:54819", "MA:0001593", "NCIT:C33258", "SCTID:368728006", "UMLS:C0226964", "UMLS:C1289183" ; oboInOwl:hasExactSynonym "lingual papilla", "tongue papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001726" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "papilla of tongue" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005020 ], _:genid119419 . obo:UBERON_0001727 obo:IAO_0000115 "A specialized receptor organ that is a collection of cells spanning the gustatory epithelium." ; obo:RO_0002171 obo:UBERON_0002467 ; obo:UBPROP_0000001 "A chemoreceptive organ.[AAO]", "One of a number of receptor cell nests located in the epithelium of the papillae of the tongue and in the soft palate, epiglottis, and pharynx that mediate the sense of taste. [TFD][VHOG]" ; obo:UBPROP_0000003 "Experients in amphibia have shown that an intrinsic feature of the pharyngeal endoderm is its ability to generate taste buds and this capacity must have been acquired by the endoderm at the origin of the vertebrates.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans, saste buds may be found on the tongue, soft palatte, epiglottis and upper pharynx. In other species they may be found in more unusual places, such as the trunk, or on the barbels or fins of fish." ; obo:UBPROP_0000011 "arise by inductive interactions between epithelial cells and invading gustatory cells from chorda tympani (facial), glossophrayngeal and vagues nerves ISBN:1607950324 (todo - request cell terms from CL)" ; oboInOwl:hasDbXref "AAO:0010573", "BIRNLEX:4101", "BTO:0000989", "CALOHA:TS-1015", "EMAPA:35850", "FMA:54825", "GAID:815", "MA:0001591", "MESH:D013650", "NCIT:C96518", "SCTID:362099006", "TAO:0001074", "UMLS:C0039337", "VHOG:0000130", "Wikipedia:Taste_bud", "XAO:0000445", "ZFA:0001074", "http://uri.neuinfo.org/nif/nifstd/nifext_14" ; oboInOwl:hasExactSynonym "tastebud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caliculus gustatorius", "taste buds", "taste-bud", "tastebuds" ; oboInOwl:id "UBERON:0001727" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "taste bud" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050912 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001033 ], _:genid119424, _:genid119426, _:genid119428, _:genid119430 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5a/Gray1018.png"^^xsd:anyURI . obo:UBERON_0001728 obo:IAO_0000115 "The section of the pharynx that lies above the soft palate." ; obo:UBPROP_0000001 "The uppermost of the three regions of the throat (pharynx), situated behind the nasal cavity and extending from the posterior nares to the level above the soft palate. [TFD][VHOG]" ; obo:UBPROP_0000007 "nasopharyngeal" ; obo:UBPROP_0000008 "In humans - in front it communicates through the choanae with the nasal cavities. On its lateral wall is the pharyngeal ostium of the auditory tube, somewhat triangular in shape, and bounded behind by a firm prominence, the torus tubarius or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane" ; oboInOwl:hasDbXref "BTO:0000662", "CALOHA:TS-0663", "EHDAA2:0001239", "EHDAA:7086", "EMAPA:17670", "EV:0100066", "FMA:54878", "GAID:339", "MA:0000443", "MAT:0000447", "MESH:D009305", "NCIT:C12423", "SCTID:181200003", "UMLS:C0027442", "VHOG:0000375", "Wikipedia:Nasopharynx" ; oboInOwl:hasExactSynonym "nasal part of pharynx", "rhinopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Nasenrachenraum", "epipharynx", "pars nasalis pharyngis" ; oboInOwl:id "UBERON:0001728" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "nasopharynx" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001042 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg"^^xsd:anyURI . obo:UBERON_0001730 oboInOwl:hasDbXref "EMAPA:37627", "FMA:54921", "MA:0001756", "SCTID:279550004" ; oboInOwl:hasExactSynonym "laryngeal extrinsic ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001730" ; a owl:Class ; rdfs:label "extrinsic ligament of larynx" ; rdfs:subClassOf obo:UBERON_0001743 . obo:UBERON_0001731 obo:IAO_0000115 "An anatomical space that is enclosed by a pharynx." ; obo:UBPROP_0000008 "See notes for pharynx - as a grouping class this is probably too bad. We exclude WBbt:0005790 (pharyngeal lumen) because of the developmental relationship" ; obo:UBPROP_0000011 "TOODO check" ; oboInOwl:hasDbXref "AAO:0010435", "BSA:0000113", "BTO:0002097", "EMAPA:18381", "FMA:54935", "SCTID:180543003", "XAO:0000105" ; oboInOwl:hasExactSynonym "lumen of pharynx", "pharyngeal cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas pharyngealis", "cavitas pharyngis" ; oboInOwl:id "UBERON:0001731" ; a owl:Class ; rdfs:label "cavity of pharynx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006562 ], _:genid119459, _:genid119462 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0006562 ] ) ] . obo:UBERON_0001732 obo:IAO_0000115 "The lymph tissue in the roof and posterior wall of the nasopharynx." ; oboInOwl:hasDbXref "BTO:0000777", "EV:0100054", "FMA:54970", "GAID:1288", "MA:0000774", "MESH:D000234", "NCIT:C33318", "SCTID:181199001", "UMLS:C0001428", "Wikipedia:Pharyngeal_tonsil" ; oboInOwl:hasExactSynonym "adenoid", "nasopharyngeal tonsil", "tonsil of Luschka", "tonsilla pharyngealis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Rachenmandel", "tonsilla pharyngea" ; oboInOwl:id "UBERON:0001732" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pharyngeal tonsil" ; rdfs:subClassOf obo:UBERON_0002372, obo:UBERON_0012330, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ], _:genid118893 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/be/Gray994-adenoid.png"^^xsd:anyURI . obo:UBERON_0001733 obo:IAO_0000115 "The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate." ; obo:UBPROP_0000001 "A muscular arch-shaped structure that is composed of the musculus uvuli and parts of tensor veli palatini, levator veli palatini, palatoglossus and palatopharyngeus and attaches to the hard palate and modulates the connections between the oral cavity and pharynx soft tissue arch .[FEED]" ; obo:UBPROP_0000007 "velar" ; oboInOwl:hasDbXref "BTO:0005405", "EMAPA:18949", "FMA:55021", "GAID:1284", "MA:0002412", "MAT:0000039", "MESH:D010160", "MIAA:0000039", "NCIT:C12231", "SCTID:245784004", "UMLS:C0030219", "Wikipedia:Soft_palate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular palate", "palatum molle", "velum", "velum palatinum" ; oboInOwl:id "UBERON:0001733" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "soft palate" ; rdfs:subClassOf obo:UBERON_0034921, _:genid119476, _:genid119478 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg"^^xsd:anyURI . obo:UBERON_0001734 obo:IAO_0000115 "Conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers." ; obo:UBPROP_0000008 "In a study of eight mammals a small underdeveloped uvula was found only in baboons" ; oboInOwl:hasDbXref "BTO:0002204", "EFO:0001386", "FMA:55022", "GAID:1285", "MESH:D014609", "NCIT:C12232", "SCTID:362082005", "UMLS:C0042173", "Wikipedia:Palatine_uvula" ; oboInOwl:hasExactSynonym "palatine uvula", "uvula", "uvula of palate", "uvula palatina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "uvula palatina" ; oboInOwl:id "UBERON:0001734" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "seeAlso - bifid uvula and cleft palate" ; rdfs:label "palatine uvula" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ], _:genid118911 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg"^^xsd:anyURI . obo:UBERON_0001735 obo:IAO_0000115 "The circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils." ; oboInOwl:hasDbXref "FMA:55070", "MA:0000752", "NCIT:C73468", "SCTID:56411004", "UMLS:C0459892", "Wikipedia:Waldeyer's_ring" ; oboInOwl:hasExactSynonym "Waldeyer's ring", "Waldeyer's tonsillar ring", "anulus lymphoideus pharyngis", "oropharyngeal lymphoid tissue", "pharyngeal lymphatic ring", "pharyngeal lymphoid ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001735" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tonsillar ring" ; rdfs:seeAlso obo:FMA_79771 ; rdfs:subClassOf obo:UBERON_0001961, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] . obo:UBERON_0001736 obo:IAO_0000115 "Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible." ; obo:UBPROP_0000001 "Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG]" ; obo:UBPROP_0000003 "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans, they account for 70% of the salivary volume and weigh about 15 grams. [WP,unvetted]", "In mouse, multilobed and lobulated, on the ventral midline of the neck", "in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty[MGI:anna]" ; obo:UBPROP_0000011 "The submandibular is the first major salivary gland to develop in the embryo, followed by the neighbouring sublingual and then the parotid.[PMID:17336109]" ; obo:UBPROP_0000013 "The term submandibular as used in humans, is incorrect due the difference in topography of these structures[http://www.avdc.org]" ; oboInOwl:hasDbXref "BTO:0001316", "CALOHA:TS-0988", "EFO:0001387", "EMAPA:18812", "EV:0100061", "FMA:55093", "GAID:942", "MA:0001589", "MESH:D013363", "NCIT:C12233", "SCTID:181235001", "UMLS:C0038556", "VHOG:0000364", "Wikipedia:Submandibular_gland" ; oboInOwl:hasExactSynonym "mandibular gland", "mandibular salivary gland", "submandibular salivary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula submandibularis", "maxillary gland", "submaxillary gland" ; oboInOwl:id "UBERON:0001736" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "lobular, sexually dimorphic in mouse" ; rdfs:label "submandibular gland" ; rdfs:subClassOf obo:UBERON_0001829, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000165 ], _:genid118924, _:genid119501 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg"^^xsd:anyURI . obo:UBERON_0001737 obo:IAO_0000115 "A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." ; obo:UBPROP_0000001 "An anatomical cluster consisting of the epiglottus, the arytenoid cartilages, the thyroid cartilage, the cricoid cartilage and the muscles, membranes, and ligaments connecting them, and also of the mucosal covering these structures.[FEED]", "Anatomical structure consisting of a narrowly triangular chamber supported by a series of semicircular cartilages in which part of the sound-production system is located.[AAO]" ; obo:UBPROP_0000003 "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" ; obo:UBPROP_0000007 "laryngeal" ; oboInOwl:hasDbXref "AAO:0000268", "BTO:0001208", "CALOHA:TS-0532", "EFO:0000838", "EHDAA2:0004063", "EMAPA:18333", "EV:0100039", "FMA:55097", "GAID:108", "MA:0000414", "MAT:0000187", "MESH:D007830", "MIAA:0000187", "NCIT:C12420", "SCTID:181212004", "UMLS:C0023078", "VHOG:0001279", "Wikipedia:Larynx", "XAO:0003081", "galen:Larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001737" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "larynx" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003716 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ], _:genid119514 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg"^^xsd:anyURI . obo:UBERON_0001738 obo:IAO_0000115 "The largest of the laryngeal cartilages." ; obo:UBPROP_0000001 "The largest cartilage of the larynx, having two broad processes that join anteriorly to form the Adam's apple. [TFD][VHOG]" ; obo:UBPROP_0000003 "[In anura] a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) [In mammals] Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0003655", "EHDAA2:0002030", "EHDAA:9395", "EMAPA:18698", "FMA:55099", "GAID:112", "MA:0001764", "MESH:D013957", "NCIT:C33780", "SCTID:263483000", "UMLS:C0040126", "VHOG:0001365", "Wikipedia:Thyroid_cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilago thyroidea", "laryngeal prominence", "pomus", "pomus adamus" ; oboInOwl:id "UBERON:0001738" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "thyroid cartilage" ; rdfs:subClassOf obo:UBERON_0001739, _:genid119522, _:genid119524 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg"^^xsd:anyURI . obo:UBERON_0001739 obo:IAO_0000115 "The cartilaginous structures that support the larynx." ; obo:UBPROP_0000003 "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" ; obo:UBPROP_0000202 obo:FMA_64159 ; oboInOwl:hasDbXref "BTO:0003660", "EHDAA:8157", "EMAPA:18697", "FMA:55108", "GAID:107", "MA:0001758", "MESH:D007817", "NCIT:C12281", "SCTID:263482005", "UMLS:C0023050", "VHOG:0001550" ; oboInOwl:hasExactSynonym "cartilage of larynx", "cartilagines laryngeales", "larynx cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001739" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "laryngeal cartilage" ; rdfs:subClassOf obo:UBERON_0007844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010212 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010213 ], _:genid119539 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0001740 obo:IAO_0000115 "The paired triangular laryngeal cartilages located postlaterally at the level of the thyroid cartilage." ; obo:UBPROP_0000001 "Paired, anteroposteriorly elongated cartilages that are associated with the vocal cords. These cartilages are medially separated and hemispherical, and their concave side faces ventromedially.[AAO]" ; oboInOwl:hasDbXref "AAO:0000674", "EMAPA:17977", "EMAPA:18695", "FMA:55109", "GAID:109", "MA:0001759", "MESH:D001193", "NCIT:C32148", "SCTID:264446005", "UMLS:C0003943", "Wikipedia:Arytenoid_cartilage" ; oboInOwl:hasExactSynonym "arytenoid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arytenoids", "cartilagines arytenoidea", "cartilago arytaenoidea", "cartilago arytenoidea" ; oboInOwl:id "UBERON:0001740" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "arytenoid cartilage" ; rdfs:subClassOf obo:UBERON_0001739, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001737 ], _:genid119550 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray950.png"^^xsd:anyURI . obo:UBERON_0001742 obo:IAO_0000115 "The most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing." ; obo:UBPROP_0000012 "laryngeal cartilage in MP" ; oboInOwl:hasDbXref "EMAPA:37522", "FMA:55112", "MA:0001763", "NCIT:C32526", "SCTID:278990001", "UMLS:C0458526" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001742" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "epiglottic cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001739 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000388 ] ) ] . obo:UBERON_0001743 obo:IAO_0000115 "A ligament that is part of a larynx and connexts the cartilages of the larynx." ; oboInOwl:hasDbXref "EMAPA:37626", "FMA:55131", "MA:0001755", "NCIT:C32933", "SCTID:279508004", "UMLS:C0458519" ; oboInOwl:hasExactSynonym "laryngeal ligament", "larynx ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001743" ; a owl:Class ; rdfs:label "ligament of larynx" ; rdfs:subClassOf obo:UBERON_0008845 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0001744 obo:IAO_0000115 "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." ; oboInOwl:hasDbXref "BTO:0000753", "CALOHA:TS-0584", "FMA:55220", "GAID:342", "MA:0002436", "MESH:D008221", "NCIT:C13049", "SCTID:181768009", "UMLS:C0024296", "Wikipedia:Lymphoid_tissue", "galen:LymphoidTissue" ; oboInOwl:hasExactSynonym "lymphatic tissue", "lymphocytic tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001744" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lymphoid tissue" ; rdfs:subClassOf obo:UBERON_0034769, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002193 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002465 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000542 ] . obo:UBERON_0001745 obo:IAO_0000115 "A lymphoid follicle that contains a germinal center." ; oboInOwl:hasDbXref "FMA:55224", "GAID:946" ; oboInOwl:hasExactSynonym "peripheral lymphoid tissue", "secondary lymphoid nodule", "secondary lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001745" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "secondary nodular lymphoid tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0042100 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010422 ] ; owl:equivalentClass _:genid119000 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg"^^xsd:anyURI . obo:UBERON_0001746 oboInOwl:hasDbXref "EMAPA:37767", "FMA:55513", "MA:0002675", "NCIT:C33781", "SCTID:176859009", "UMLS:C0229575" ; oboInOwl:hasExactSynonym "capsula fibrosa glandulae thyroideae", "fibrous capsule of thyroid gland", "thyroid capsule", "thyroid gland capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001746" ; a owl:Class ; rdfs:label "capsule of thyroid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0001747 obo:IAO_0000115 "A parenchyma that is part of a thyroid follicle [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004579", "EMAPA:37769", "FMA:55515", "MA:0000730", "SCTID:371402001" ; oboInOwl:hasExactSynonym "parenchyma of thyroid", "parenchyma of thyroid follicle", "parenchyma of thyroid gland follicle", "thyroid follicle parenchyma", "thyroid gland follicle parenchyma", "thyroid gland parenchyma", "thyroid parenchyma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parenchyma glandulae thyroideae" ; oboInOwl:id "UBERON:0001747" ; a owl:Class ; rdfs:label "parenchyma of thyroid gland" ; rdfs:subClassOf _:genid119020, _:genid119604, _:genid119606 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 _:genid119018 ) ] . obo:UBERON_0001748 obo:IAO_0000115 "The dense and irregular connective tissue capsule surrounding a parathyroid gland." ; oboInOwl:hasDbXref "EMAPA:35663", "FMA:55566", "MA:0002676", "NCIT:C33265", "UMLS:C0927176" ; oboInOwl:hasExactSynonym "parathyroid gland capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001748" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "capsule of parathyroid gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011822 ], _:genid119621 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:UBERON_0001749 obo:IAO_0000115 "A parenchyma that is part of a parathyroid gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35664", "FMA:55569", "MA:0002677" ; oboInOwl:hasExactSynonym "parathyroid gland parenchyma", "parathyroid parenchyma", "parenchyma of parathyroid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001749" ; a owl:Class ; rdfs:label "parenchyma of parathyroid gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ], _:genid119631, _:genid119633 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid119041 ] . obo:UBERON_0001750 obo:IAO_0000115 "A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta." ; obo:IAO_0000116 "TODO - resolve canaliculus vs tear duct vs lacrimal vs nasolacrimal" ; obo:UBPROP_0000012 "this is an eye appendage in ncit, along with eyelid and eyebrow. in MA, part of eye surface part_of eye" ; oboInOwl:hasDbXref "EMAPA:35462", "FMA:55605", "GAID:901", "MA:0000274", "MESH:D007765", "NCIT:C32905", "UMLS:C0022903", "Wikipedia:Lacrimal_apparatus" ; oboInOwl:hasExactSynonym "apparatus lacrimalis", "lacrymal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lacrimal drainage system", "nasolacrimal drainage system", "nasolacrimal system" ; oboInOwl:id "UBERON:0001750" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lacrimal apparatus" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid119638, _:genid119640, _:genid119642, _:genid119644 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png"^^xsd:anyURI . obo:UBERON_0001751 obo:IAO_0000115 "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." ; obo:UBPROP_0000001 "Mineralized collagen containing substance that forms the tooth structure.[TAO]" ; obo:UBPROP_0000003 "Dentine is a bona fide vertebrate novelty, and dentine-secreting odontoblasts represent a cell type that is exclusively derived from the neural crest.[well established][VHOG]" ; obo:UBPROP_0000007 "dentinal" ; obo:UBPROP_0000008 "Dentine is found in the fossil record as early as the late Cambrian, in fish, where it may have had a role in electrochemical sensing of the environment as well as assisting in defense[WP]" ; oboInOwl:hasDbXref "BTO:0003453", "EMAPA:35281", "FMA:55628", "GAID:1272", "MA:0002542", "MESH:D003804", "NCIT:C32453", "SCTID:362112004", "TAO:0005143", "UMLS:C0011429", "VHOG:0001589", "VSAO:0000069", "Wikipedia:Dentin", "XAO:0004051", "ZFA:0005143" ; oboInOwl:hasExactSynonym "dentin", "dentine of tooth" ; oboInOwl:hasNarrowSynonym "predentin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001751" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "." ; rdfs:label "dentine" ; rdfs:subClassOf obo:UBERON_0010365, _:genid119063, _:genid119657 . obo:UBERON_0001752 obo:IAO_0000115 "A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP]." ; obo:IAO_0000116 "current classification under substance of tooth may be turned into taxon GCI (e.g. sharks have enamel in dermal denticles)" ; obo:RO_0002161 obo:NCBITaxon_9359, obo:NCBITaxon_9816 ; obo:UBPROP_0000001 "Skeletal tissue that consists of an avascular, noncollagenous, hypermineralized matrix that is deposited by ameloblasts that are excluded from the matrix. Enamel develops from organic pre-enamel tissue that is replaced by a largely inorganic matrix.[VSAO]" ; obo:UBPROP_0000012 "part_of tooth enamel organ in MA" ; oboInOwl:hasDbXref "BTO:0001844", "CALOHA:TS-1057", "EMAPA:35303", "FMA:55629", "MA:0002543", "MESH:D003743", "NCIT:C32505", "SCTID:362113009", "UMLS:C0011350", "VSAO:0000065", "Wikipedia:Enamel_organ", "XAO:0004198" ; oboInOwl:hasExactSynonym "enamel of tooth", "enamel tissue", "tooth enamel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "enameloid" ; oboInOwl:id "UBERON:0001752" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "enamel" ; rdfs:subClassOf obo:UBERON_0010365, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002444 ], _:genid119667, _:genid119669 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Enamelorgan11-17-05.jpg"^^xsd:anyURI . obo:UBERON_0001753 obo:IAO_0000115 "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." ; obo:UBPROP_0000001 "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.[VSAO]", "Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth[FMA:55630]." ; obo:UBPROP_0000008 "Cementum, the supporting tissue that anchors mammalian and crocodylian teeth into their sockets, differs among species and can have features of dentine, of bone, and of calcified cartilage, as well as unique features. Cementum is deposited by cementoblasts onto existing dentine. As in bone and dentine, cementoblasts produce an organic matrix, the main constituent of which is collagen type I (Bosshardt, 2005), but cementum, dentine, and bone also share a number of important noncollagenous matrix components such as osteopontin, osteocalcin, bone sialoprotein, a2-HS- glycoprotein, dentine matrix protein, dentine sialoprotein, and den- tine phosphoprotein (McKee et al., 1996; Bosshardt, 2005). it has been argued that in all rodents and ruminants, cementum is a form of calcified cartilage[H&W]" ; oboInOwl:hasDbXref "BTO:0002525", "CALOHA:TS-2163", "EMAPA:35203", "FMA:55630", "MA:0002541", "MESH:D003739", "NCIT:C32276", "SCTID:362114003", "UMLS:C0011343", "VSAO:0000062", "Wikipedia:Cementum", "XAO:0004196" ; oboInOwl:hasExactSynonym "cement", "cement of tooth", "cementum", "cementum of tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of attachment" ; oboInOwl:id "UBERON:0001753" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cementum" ; rdfs:subClassOf obo:UBERON_0010365, _:genid119679 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg"^^xsd:anyURI . obo:UBERON_0001754 obo:IAO_0000115 "The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP]." ; obo:UBPROP_0000001 "Material in the center of the dentine of the mature tooth. In secondary teeth the pulp contains blood vessels and odontoblast.[TAO]" ; obo:UBPROP_0000003 "The oral cavity of vertebrates is generally thought to arise as an ectodermal invagination. Consistent with this, oral teeth are proposed to arise exclusively from ectoderm, contributing to tooth enamel epithelium, and from neural crest derived mesenchyme, contributing to dentin and pulp (reference 1); Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin (reference 2).[uncertain][VHOG]" ; oboInOwl:hasDbXref "BTO:0000339", "CALOHA:TS-0195", "EMAPA:35274", "FMA:55631", "GAID:1270", "MA:0001599", "MESH:D003782", "NCIT:C32451", "SCTID:362110007", "TAO:0005141", "UMLS:C0011399", "VHOG:0001469", "Wikipedia:Dental_pulp", "ZFA:0005141" ; oboInOwl:hasExactSynonym "pulp of tooth", "tooth pulp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dental pulp cell" ; oboInOwl:id "UBERON:0001754" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dental pulp" ; rdfs:subClassOf obo:UBERON_0011825, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001091 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000060 ], _:genid119690 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg"^^xsd:anyURI . obo:UBERON_0001756 obo:IAO_0000115 "The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO]." ; obo:UBPROP_0000001 "The intermediate portion of the ear which consists of a small air-filled and membrane-lined chamber. It is lodged in the temporal bone and continues with the nasopharynx through the Eustachian tube. It is separated from the external ear by the tympanic membrane and from the inner ear by the fenestrae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[uncertain][VHOG]" ; oboInOwl:hasDbXref "AAO:0011065", "BIRNLEX:1695", "BTO:0002099", "CALOHA:TS-2233", "EHDAA2:0001181", "EHDAA:5693", "EMAPA:17000", "EV:0100357", "FMA:56513", "GAID:165", "MA:0000253", "MAT:0000146", "MESH:D004432", "MIAA:0000146", "NCIT:C12274", "SCTID:181185000", "UMLS:C0013455", "UMLS:C1268972", "VHOG:0000312", "Wikipedia:Middle_ear", "XAO:0000191" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auris media" ; oboInOwl:id "UBERON:0001756" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "middle ear" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001690 ] . obo:UBERON_0001757 obo:IAO_0000115 "The part of the ear that projects from the head, connecting to the external acoustic meatus." ; obo:UBPROP_0000001 "The external expanded part of the ear characterized by a funnel-shaped structure through which the sound vibrations are received. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "Mammals have a third type of tympanic ear. An external flap, the auricle or pinna, helps funnel sound waves down the external acoustic meatus to the tympanic membrane.[well established][VHOG]" ; obo:UBPROP_0000008 "In various species, the pinna can also signal mood and radiate heat" ; obo:UBPROP_0000009 "The purpose of the pinna is to collect sound. It does so by acting as a funnel, amplifying the sound and directing it to the ear canal. While reflecting from the pinna, sound also goes through a filtering process which adds directional information to the sound (see sound localization, head-related transfer function, pinna notch)." ; oboInOwl:hasDbXref "EHDAA2:0001467", "EMAPA:17589", "EV:0100355", "FMA:56580", "MA:0000259", "NCIT:C32165", "SCTID:421159007", "UMLS:C0928075", "VHOG:0000460", "Wikipedia:Pinna_(anatomy)", "galen:Auricle" ; oboInOwl:hasExactSynonym "auricle", "auricle of ear", "auricle of external ear", "auricula", "auricula (auris externa)", "pinna of ear" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pinnae" ; oboInOwl:id "UBERON:0001757" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pinna" ; rdfs:subClassOf obo:UBERON_0001444, _:genid119109, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001297 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001352 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006208 ] . obo:UBERON_0001758 obo:IAO_0000115 "The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO]." ; obo:UBPROP_0000012 "FMA treats periodontium and periodontal ligament as the same" ; oboInOwl:hasDbXref "BTO:0001021", "CALOHA:TS-2380", "GAID:216", "MESH:D010519", "NCIT:C33304", "UMLS:C0031093", "Wikipedia:Periodontium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "paradentium", "periodontal ligament", "periodontal membrane", "tooth supporting structure" ; oboInOwl:id "UBERON:0001758" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "periodontium" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001091 ], _:genid119717, _:genid119719 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg"^^xsd:anyURI . obo:UBERON_0001759 obo:IAO_0000115 "Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart)." ; obo:UBPROP_0000001 "Nerve consisting of branchiomotor and visceral efferent fibers which branch and innervate the smooth muscles and glands of the heart, lungs, esophagus, and stomach as well as some throat muscles. Sensory fibers supply mucosa of the mouth and pharynx.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "10n" ; oboInOwl:hasDbXref "AAO:0010475", "BAMS:10n", "BAMS:Xn", "BIRNLEX:801", "BTO:0003472", "EFO:0002549", "EMAPA:37797", "FMA:5731", "GAID:721", "HBA:9337", "MA:0001106", "MBA:917", "MESH:D014630", "NCIT:C12812", "SCTID:362466001", "TAO:0000453", "UMLS:C0042276", "UMLS:C1305910", "VHOG:0000737", "Wikipedia:Vagus_nerve", "XAO:0003097", "ZFA:0000453", "galen:VagusNerve", "neuronames:702" ; oboInOwl:hasExactSynonym "nervus vagus [x]", "tenth cranial nerve", "vagus", "vagus X nerve", "vagus nerve [X]", "vagus nerve tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-X", "cranial nerve X", "nerve X", "nervus vagus", "pneuomgastric nerve", "vagal nerve", "vagus nerve or its root" ; oboInOwl:id "UBERON:0001759" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vagus nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002075 ], _:genid119734, _:genid119736 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0011775 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png"^^xsd:anyURI . obo:UBERON_0001760 obo:IAO_0000115 "The frontal sinus occupies the dorsal part of the skull medial to the orbit. It overlaps cranial and nasal cavities and is often referred to as the conchofrontal sinus." ; obo:UBPROP_0000008 "A unique feature in the horse is that the frontal sinus communicates with the caudal maxillary sinus via the frontomaxillary opening" ; oboInOwl:hasDbXref "FMA:57417", "GAID:357", "MA:0001793", "MESH:D005626", "NCIT:C12277", "SCTID:181205008", "UMLS:C0016734", "Wikipedia:Frontal_sinus" ; oboInOwl:hasExactSynonym "cavity of frontal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinus frontales" ; oboInOwl:id "UBERON:0001760" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "frontal sinus" ; rdfs:subClassOf obo:UBERON_0001825 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg"^^xsd:anyURI . obo:UBERON_0001763 obo:IAO_0000115 "A condensation of odontoblasts that forms the part of a tooth germ that gives rise to dentin and pulp in the mature tooth. It lies below a cellular aggregation known as the enamel organ." ; obo:UBPROP_0000001 "Cell condensation that is a well-defined population of densely organized mesenchymal cells that aggregates adjacent to an epithelium.[VSAO]", "Tissue of the developing tooth. It is composed of pre-odontoblast and undiffentiated mesnchyme cells and connects to the basal lamina.[TAO]" ; obo:UBPROP_0000003 "Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin.[uncertain][VHOG]" ; obo:UBPROP_0000011 "In humans, the dental papilla appears after 8-10 weeks intra uteral life" ; oboInOwl:hasDbXref "BTO:0001839", "EMAPA:32892", "FMA:57662", "GAID:1277", "MA:0001598", "MESH:D003771", "TAO:0005140", "VHOG:0001465", "VSAO:0000025", "Wikipedia:Dental_papilla", "XAO:0004045", "ZFA:0005140" ; oboInOwl:hasExactSynonym "odontogenic condensation" ; oboInOwl:hasNarrowSynonym "pharyngeal tooth mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dental papilla", "dentinal papilla", "dermal papilla", "papilla dentis", "tooth mesenchyme" ; oboInOwl:id "UBERON:0001763" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "odontogenic papilla" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0005176 ], _:genid119766 ; owl:equivalentClass _:genid119158 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray1011.png"^^xsd:anyURI . obo:UBERON_0001764 obo:IAO_0000115 "One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity." ; oboInOwl:hasDbXref "CALOHA:TS-2231", "FMA:57715", "GAID:358", "MA:0001794", "MESH:D008443", "NCIT:C12275", "SCTID:181204007", "UMLS:C0024957", "Wikipedia:Maxillary_sinus" ; oboInOwl:hasExactSynonym "antrum of Highmore", "sinus maxilliaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Highmore antrum", "maxillary antrum" ; oboInOwl:id "UBERON:0001764" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "maxillary sinus" ; rdfs:subClassOf obo:UBERON_0001825, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002397 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000033 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray1199.png"^^xsd:anyURI . obo:UBERON_0001765 obo:IAO_0000115 "Epithelial tube that transports milk[GO]." ; oboInOwl:hasDbXref "BTO:0002845", "CALOHA:TS-2385", "EMAPA:35538", "FMA:58006", "MA:0000791", "NCIT:C32910", "SCTID:361719004", "UMLS:C0222613", "Wikipedia:Lactiferous_duct" ; oboInOwl:hasExactSynonym "lactiferous duct", "lactiferous gland duct", "mammary gland duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus lactiferi", "galactophorous duct", "galactophorous tubule", "lactiferous tubule", "mammilary duct" ; oboInOwl:id "UBERON:0001765" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "This structure regresses in most males" ; rdfs:label "mammary duct" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001911 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001913 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0002030 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg"^^xsd:anyURI . obo:UBERON_0001766 obo:IAO_0000115 "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." ; obo:UBPROP_0000001 "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" ; obo:UBPROP_0000012 "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" ; oboInOwl:hasDbXref "BTO:0002084", "EHDAA2:0000129", "EHDAA:9033", "EMAPA:18231", "FMA:58078", "GAID:889", "MA:0000262", "MESH:D000867", "NCIT:C12667", "SCTID:181160009", "UMLS:C0003151", "VHOG:0001431", "Wikipedia:Anterior_chamber_of_eyeball" ; oboInOwl:hasExactSynonym "anterior chamber", "anterior chamber of eye", "camera anterior", "eye anterior chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "camera anterior bulbi", "camera anterior bulbi oculi", "camera oculi anterior" ; oboInOwl:id "UBERON:0001766" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anterior chamber of eyeball" ; rdfs:subClassOf obo:UBERON_0006311, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001801 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001768 obo:IAO_0000115 "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." ; obo:IAO_0000116 "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" ; obo:UBPROP_0000007 "uveal" ; oboInOwl:hasDbXref "CALOHA:TS-2228", "EMAPA:35901", "FMA:58103", "GAID:912", "MA:0002480", "MESH:D014602", "NCIT:C12811", "SCTID:280648000", "UMLS:C0042160", "Wikipedia:Uvea" ; oboInOwl:hasExactSynonym "tunica vasculosa of eyeball", "uvea", "uveal tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pars iridica retinae", "tunica vasculatis oculi", "tunica vasculosa bulbi", "vascular layer of eyeball" ; oboInOwl:id "UBERON:0001768" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "uvea" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001769 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001775 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001776 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png"^^xsd:anyURI . obo:UBERON_0001769 obo:IAO_0000115 "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." ; obo:UBPROP_0000001 "The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; obo:UBPROP_0000007 "iridial" ; obo:UBPROP_0000008 "The avian iris and ciliary body undergoes a transition from smooth-to-striated muscle during embryonic development [DOI:dx.doi.org/10.1006/dbio.1998.9019]" ; oboInOwl:hasDbXref "AAO:0010347", "BTO:0000653", "CALOHA:TS-0491", "EFO:0004245", "EMAPA:19154", "EV:0100345", "FMA:58235", "GAID:917", "MA:0000273", "MESH:D007498", "NCIT:C12737", "SCTID:181164000", "TAO:0001238", "UMLS:C0022077", "VHOG:0000101", "Wikipedia:Iris_(anatomy)", "XAO:0000185", "ZFA:0001238" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior uvea", "irides", "irises" ; oboInOwl:id "UBERON:0001769" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "iris" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011892 ], _:genid119830 . obo:UBERON_0001771 obo:IAO_0000115 "The central circular aperture of the iris through which light rays enter the eye." ; obo:UBPROP_0000001 "The circular orifice in the centre of the iris, through which light enters into the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010351", "FMA:58252", "GAID:918", "MA:0001292", "MESH:D011680", "NCIT:C33429", "SCTID:35146001", "TAO:0001283", "UMLS:C0034121", "VHOG:0000116", "Wikipedia:Pupil", "XAO:0000283", "ZFA:0001283" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pupils" ; oboInOwl:id "UBERON:0001771" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pupil" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001769 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/65/Eye_iris.jpg"^^xsd:anyURI . obo:UBERON_0001772 obo:IAO_0000115 "The smooth stratified squamous epithelium that covers the outer surface of the cornea." ; obo:UBPROP_0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" ; obo:UBPROP_0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei", "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" ; oboInOwl:hasDbXref "BTO:0000287", "CALOHA:TS-0173", "EFO:0001917", "EHDAA2:0000319", "EMAPA:17162", "FMA:58263", "GAID:895", "MA:0001243", "MESH:D019573", "NCIT:C12928", "SCTID:368825001", "TAO:0002187", "UMLS:C0459875", "Wikipedia:Corneal_epithelium", "ZFA:0001683" ; oboInOwl:hasExactSynonym "anterior corneal epithelium", "cornea epithelial tissue", "cornea epithelium", "epithelial tissue of cornea", "epithelium anterius (cornea)", "epithelium anterius corneae", "epithelium corneæ anterior layer", "epithelium of cornea", "external epithelium of cornea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior endothelium of cornea", "e. anterius corneae", "endothelium anterius corneae", "endothelium camerae anterioris bulbi", "endothelium corneale", "epithelium posterius corneae" ; oboInOwl:id "UBERON:0001772" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "corneal epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000964 ], _:genid119851 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000964 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png"^^xsd:anyURI . obo:UBERON_0001773 obo:IAO_0000115 "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." ; obo:UBPROP_0000001 "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera].", "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" ; obo:UBPROP_0000007 "scleral" ; obo:UBPROP_0000008 "in fish, reptiles and monotremes the connective tissue of the sclera is skeletal" ; obo:UBPROP_0000010 "continuous with the dura mater and the cornea; The sclera forms the posterior five-sixths of the connective tissue coat of the globe." ; obo:UBPROP_0000011 "Majority derives from NC that surrounds optic cup of neurectoderm; a small temporal portion develops from the mesoderm that contributes to striated extra-ocular muscles and vascular endothelia[Rada&Johnson].", "Seko et al demonstrate chondrogenic potential and identify this as connective tissue[DOI:10.1371/journal.pone.0003709]." ; oboInOwl:hasDbXref "AAO:0010354", "BTO:0001606", "EMAPA:19027", "EV:0100342", "FMA:58269", "GAID:911", "MA:0000280", "MESH:D012590", "NCIT:C12784", "SCTID:181163006", "UMLS:C0036410", "VHOG:0001274", "Wikipedia:Sclera", "XAO:0000183", "ZFA:0005563" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "scleral capsule" ; oboInOwl:id "UBERON:0001773" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Disease notes: implicated in rheumatoid arthritis." ; rdfs:label "sclera" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000963 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid119867, _:genid119869, _:genid119872, _:genid119874 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001774 obo:IAO_0000115 "A skeletal muscle organ that is part of the trunk region." ; obo:IAO_0000116 "Note that this class excludes smooth muscle elements in the trunk region, such as the internal anal sphincter. This appears to be consistent with other ontologies such as FMA and ZFA which appear to only include skeletal muscles here. In fact the MA class 'trunk muscle' is classified as a 'set of skeletal muscles'." ; obo:UBPROP_0000012 "Many ontologies do not appear to have a coherent distinction between an individual muscle and the musculature (i.e. the set of muscles in a region), so we group all together here." ; oboInOwl:hasDbXref "AAO:0000611", "EMAPA:35888", "FMA:58274", "MA:0000514", "TAO:0000473", "XAO:0003230", "ZFA:0000473" ; oboInOwl:hasExactSynonym "body musculature", "muscle of trunk", "muscle organ of torso", "muscle organ of trunk", "torso muscle organ", "trunk muscle", "trunk muscle organ", "trunk musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001774" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "skeletal muscle of trunk" ; rdfs:subClassOf _:genid119885 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0001775 obo:IAO_0000115 "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." ; obo:UBPROP_0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010341", "BTO:0000260", "CALOHA:TS-0694", "EMAPA:19065", "EV:0100346", "FMA:58295", "GAID:916", "MA:0000264", "MESH:D002924", "NCIT:C12345", "SCTID:263340007", "UMLS:C0008779", "VHOG:0000102", "Wikipedia:Ciliary_body", "XAO:0000186", "neuronames:1571" ; oboInOwl:hasExactSynonym "ocular ciliary body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior uvea", "ciliary bodies", "corpus ciliare" ; oboInOwl:id "UBERON:0001775" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ciliary body" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011892 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001605 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010427 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011892 ], _:genid119897 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001776 obo:IAO_0000115 "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." ; obo:IAO_0000116 "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" ; obo:UBPROP_0000007 "choroidal" ; obo:UBPROP_0000012 "MP treats posterior uvea and optic choroid as distinct" ; oboInOwl:hasDbXref "BTO:0001829", "CALOHA:TS-2054", "EMAPA:19077", "EV:0100347", "FMA:58298", "GAID:913", "MA:0000263", "MESH:D002829", "NCIT:C12344", "SCTID:181172003", "TAO:0005229", "UMLS:C0008520", "VHOG:0001568", "Wikipedia:Choroid", "ZFA:0005229" ; oboInOwl:hasExactSynonym "choroid", "choroid coat", "choroidea", "eye choroid", "posterior uvea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chorioid", "choroidea", "optic choroid" ; oboInOwl:id "UBERON:0001776" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "optic choroid" ; rdfs:subClassOf obo:UBERON_0002049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0019207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001773 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0011892 ], _:genid119299, _:genid119905, _:genid119908 ; owl:disjointWith obo:UBERON_0011892 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001777 obo:IAO_0000115 "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." ; obo:UBPROP_0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" ; obo:UBPROP_0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]", "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" ; oboInOwl:hasBroadSynonym "substantia propria" ; oboInOwl:hasDbXref "CALOHA:TS-1138", "EFO:0002514", "EMAPA:17602", "FMA:58306", "GAID:893", "MA:0001245", "MESH:D003319", "NCIT:C12699", "SCTID:362511000", "TAO:0002189", "UMLS:C0010040", "Wikipedia:Corneal_stroma", "ZFA:0001685" ; oboInOwl:hasExactSynonym "corneal stroma", "stroma of cornea", "substantia propria corneae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001777" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "substantia propria of cornea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004367 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004370 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000964 ], _:genid119930 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png"^^xsd:anyURI . obo:UBERON_0001778 obo:IAO_0000115 "A double layer covering the ciliary body that produces aqueous humor." ; oboInOwl:hasDbXref "BTO:0001770", "CALOHA:TS-0695", "EMAPA:35239", "FMA:58464", "MA:0001238", "NCIT:C32314", "SCTID:280870004", "UMLS:C0459736", "Wikipedia:Ciliary_body#Ciliary_epithelium" ; oboInOwl:hasExactSynonym "ciliary body epithelium", "epithelium of ciliary body", "ocular ciliary epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001778" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ciliary epithelium" ; rdfs:subClassOf obo:UBERON_0000488, _:genid119947, _:genid119949, _:genid119951 ; owl:equivalentClass _:genid119329 . obo:UBERON_0001779 obo:IAO_0000115 "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." ; oboInOwl:hasDbXref "EMAPA:35451", "FMA:58526", "MA:0002777", "SCTID:280882008", "Wikipedia:Iris_stroma", "ZFA:0005569" ; oboInOwl:hasExactSynonym "iridial stroma", "stroma of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001779" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "iris stroma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001769 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png"^^xsd:anyURI . obo:UBERON_0001780 obo:IAO_0000115 "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." ; obo:UBPROP_0000001 "Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG]" ; oboInOwl:hasDbXref "AAO:0011101", "BAMS:spin", "BTO:0000870", "EHDAA2:0001898", "EMAPA:16989", "FMA:5858", "GAID:841", "MA:0000233", "MESH:D013127", "NCIT:C12792", "SCTID:361099009", "UMLS:C0037941", "VHOG:0000824", "Wikipedia:Spinal_nerve", "XAO:0003101", "neuronames:1228" ; oboInOwl:hasExactSynonym "backbone nerve", "nerve of backbone", "nerve of spinal column", "nerve of spine", "nerve of vertebral column", "spinal column nerve", "spinal nerve tree", "spine nerve", "vertebral column nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi spinales", "spinal nerves" ; oboInOwl:id "UBERON:0001780" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "spinal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg"^^xsd:anyURI . obo:UBERON_0001781 obo:IAO_0000115 "Any of the layers that make up the retina[MP]." ; obo:UBPROP_0000012 "MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers" ; oboInOwl:hasDbXref "AAO:0010353", "EMAPA:35742", "FMA:58617", "MA:0001319", "NCIT:C49328", "SCTID:280657006", "UMLS:C0459649", "XAO:0000266" ; oboInOwl:hasExactSynonym "retina layer", "retina neuronal layer", "retinal layer", "retinal neuronal layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001781" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "layer of retina" ; rdfs:subClassOf obo:UBERON_0022303, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:UBERON_0001782 obo:IAO_0000115 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." ; obo:UBPROP_0000001 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]", "The monolayer of pigmented epithelium covering the neural retina.[AAO]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011096", "BTO:0001177", "CALOHA:TS-0869", "EHDAA2:0001465", "EHDAA:4765", "EMAPA:17172", "EMAPA:35738", "FMA:58627", "MA:0000279", "MA:0003173", "NCIT:C33470", "SCTID:280662007", "TAO:0000144", "UMLS:C0035322", "VHOG:0000536", "Wikipedia:Retinal_pigment_epithelium", "XAO:0003217", "ZFA:0000144" ; oboInOwl:hasExactSynonym "outer pigmented layer of retina", "pigment epithelium of retina", "pigmented retina epithelium", "pigmented retinal epithelium", "retinal pigment epithelium", "retinal pigmented epithelium", "stratum pigmentosum (retina)", "stratum pigmentosum retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PRE", "RPE", "epithelium, retinal pigment", "p. pigmentosa retinae", "pigmented epithelium", "pigmented retina", "retinal pigment layer", "stratum pigmentosa retinae" ; oboInOwl:id "UBERON:0001782" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pigmented layer of retina" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0048770 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003902 ], _:genid119993 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001781 [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0005424 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png"^^xsd:anyURI . obo:UBERON_0001783 obo:IAO_0000115 "The optic disc or optic nerve head is the location where ganglion cell axons exit the eye to form the optic nerve. There are no light sensitive rods or cones to respond to a light stimulus at this point. This causes a break in the visual field called 'the blind spot' or the 'physiological blind spot'. The optic nerve head in a normal human eye carries from 1 to 1.2 million neurons from the eye towards the brain. [WP,unvetted]." ; obo:UBPROP_0000001 "The small blind spot on the surface of the retina. It is the point where the fibers of the retina leave the eye and become part of the optic nerve. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "CALOHA:TS-2153", "EFO:0001974", "EHDAA2:0001307", "EHDAA:9077", "EMAPA:18238", "FMA:58634", "MA:0000278", "MESH:D009898", "NCIT:C12760", "SCTID:362518006", "UMLS:C0029127", "VHOG:0000551", "Wikipedia:Optic_disc" ; oboInOwl:hasExactSynonym "optic disk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "optic disk", "optic nerve disc", "optic nerve head", "optic papilla", "physiologic blind spot", "physiologic blind spot of mariotte" ; oboInOwl:id "UBERON:0001783" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "optic disc" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000941 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Gray879.png"^^xsd:anyURI . obo:UBERON_0001785 obo:IAO_0000115 "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." ; obo:IAO_0000116 "classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN." ; obo:UBPROP_0000001 "Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG]" ; obo:UBPROP_0000012 "See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6" ; oboInOwl:hasDbXref "AAO:0000108", "BAMS:cran", "BIRNLEX:1623", "BTO:0001104", "EHDAA2:0000323", "EMAPA:17264", "FMA:5865", "GAID:802", "HBA:9299", "MA:0000215", "MBA:967", "MESH:D003391", "NCIT:C12700", "SCTID:244447006", "TAO:0000641", "UMLS:C0010268", "UMLS:C1269897", "VHOG:0000279", "Wikipedia:Cranial_nerve", "XAO:0000429", "XAO:0003089", "ZFA:0000641", "neuronames:1227" ; oboInOwl:hasExactSynonym "cranial neural tree organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial nerves", "nervus cranialis" ; oboInOwl:id "UBERON:0001785" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cranial nerve" ; rdfs:subClassOf obo:UBERON_0034713, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003099 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0001780 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg"^^xsd:anyURI . obo:UBERON_0001786 obo:IAO_0000115 "A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity." ; obo:UBPROP_0000001 "A small pit in the center of the macula lutea, the area of clearest vision, where the retinal layers are spread aside, and light falls directly on the cones. [TFD][VHOG]" ; obo:UBPROP_0000003 "Definition of fovea centralis should be considered here as 'an area centralis at the visual axis' (reference 1). There is an uncertaincy of the relation, because: 1.-The fovea first appeared in evolution in the temporal retina of fishes. Then, in birds, the nasal fovea and bifoveal system with nasal and temporal foveas developed. The fovea disappeared in primitive mammals, and reappeared in primates. A residue of the fovea is conserved in the visual streak, and the disappearance and reappearance of the fovea, in primitive mammals and primates respectively, correlates with degeneration and restoration of cone pigment genes in photoreceptors (reference 2). 2.-Many retinal features (foveas, trichromacy, midget pathways and associated cell types) appear specific to primates. This has led to investigations in parallel with other mammalian models such as cat or rabbit. Correlation of the results often proves to be difficult, since an evolutionary scenario with transitions between the mammalian models is largely lacking (reference 3).[uncertain][VHOG]" ; obo:UBPROP_0000007 "foveal" ; obo:UBPROP_0000008 "The fovea is also a pit in the surface of the retinas of many types of fish, reptiles, and birds. Among mammals, it is found only in simian primates. The retinal fovea takes slightly different forms in different types of animals. For example, in primates, cone photoreceptors line the base of the foveal pit, the cells that elsewhere in the retina form more superficial layers having been displaced away from the foveal region during late fetal and early postnatal life. Other foveae may show only a reduced thickness in the inner cell layers, rather than an almost complete absence" ; obo:UBPROP_0000009 "high acuity vision" ; oboInOwl:hasBroadSynonym "fovea" ; oboInOwl:hasDbXref "BIRNLEX:2543", "CALOHA:TS-2055", "EMAPA:37589", "EV:0100350", "FMA:58658", "GAID:910", "MA:0001307", "MESH:D005584", "NCIT:C26463", "SCTID:264479005", "UMLS:C0016622", "UMLS:C0450290", "VHOG:0001572", "Wikipedia:Fovea_centralis_in_macula" ; oboInOwl:hasExactSynonym "centre of macula", "fovea centralis in macula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "centre of fovea" ; oboInOwl:id "UBERON:0001786" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "fovea centralis" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000053 ], _:genid119419, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_28838 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000573 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001787 obo:IAO_0000115 "The layer within the retina where the photoreceptor cell receptor segments reside." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; obo:UBPROP_0000012 "we follow MA and ZFA in subdividing this into inner and outer segments" ; oboInOwl:hasDbXref "EMAPA:35686", "FMA:58680", "MA:0001308", "NCIT:C32954", "TAO:0000143", "UMLS:C0229206", "VHOG:0001165", "Wikipedia:Layer_of_rods_and_cones", "XAO:0003215", "ZFA:0000143" ; oboInOwl:hasExactSynonym "retina photoreceptor layer", "retinal photoreceptor layer", "stratum segmentorum externorum et internorum (retina)", "stratum segmentorum externorum et internorum retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "layer of rods and cones", "retinal photoreceptor layers" ; oboInOwl:id "UBERON:0001787" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "photoreceptor layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001788 ], _:genid120049 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png"^^xsd:anyURI . obo:UBERON_0001788 obo:IAO_0000115 "The row of jucntional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier[MP]." ; oboInOwl:hasDbXref "EMAPA:36518", "FMA:58683", "MA:0001309", "NCIT:C33235", "SCTID:280676008", "TAO:0001331", "UMLS:C1518685", "Wikipedia:External_limiting_membrane", "XAO:0003224", "ZFA:0001331" ; oboInOwl:hasExactSynonym "external limiting lamina of retina", "external limiting membrane", "external limiting membrane of retina", "outer limiting membrane", "outer limiting membrane of retina", "retina external limiting lamina", "retina outer limiting membrane", "stratum limitans externum (retina)", "stratum limitans externum retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "BRB", "blood retina barrier", "outer limiting membranes" ; oboInOwl:id "UBERON:0001788" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "outer limiting layer of retina" ; rdfs:subClassOf obo:UBERON_0007619, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001789 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:UBERON_0001789 obo:IAO_0000115 "The layer within the retina where the photoreceptor cell bodies reside." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "outer nuclear layer" ; oboInOwl:hasDbXref "BAMS:Ronl", "BTO:0005600", "EMAPA:19157", "FMA:58684", "MA:0001315", "NCIT:C33236", "SCTID:280678009", "TAO:0001464", "UMLS:C0229210", "VHOG:0001170", "Wikipedia:Outer_nuclear_layer", "XAO:0003219", "ZFA:0001464" ; oboInOwl:hasExactSynonym "neural retina outer nuclear layer", "retina outer nuclear layer", "retinal outer nuclear layer", "stratum nucleare externum (retina)", "stratum nucleare externum retinae" ; oboInOwl:hasNarrowSynonym "ONL" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external nuclear layer", "layer of outer granules", "retina, outer nuclear layer", "retinal outer nuclear layers" ; oboInOwl:id "UBERON:0001789" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "outer nuclear layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001790 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ], _:genid120072 . obo:UBERON_0001790 obo:IAO_0000115 "The layer within the retina where the bipolar cells synapse with the photoreceptor cells[ZFA]. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells[GO]." ; obo:UBPROP_0000001 "The layer within the retina where the bipolar cells synapse with the photoreceptor cells.[TAO]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "external plexiform layer" ; oboInOwl:hasDbXref "BAMS:Ropl", "BTO:0003174", "EMAPA:35744", "FMA:58685", "MA:0001316", "NCIT:C33237", "SCTID:280684007", "TAO:0001330", "UMLS:C0229217", "VHOG:0001171", "Wikipedia:Outer_plexiform_layer", "XAO:0003218", "ZFA:0001330" ; oboInOwl:hasExactSynonym "outer plexiform layer", "retina outer plexiform layer", "retinal outer plexiform layer", "stratum plexiforme externum", "stratum plexiforme externum retinae" ; oboInOwl:hasNarrowSynonym "OPL" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "retina, outer plexiform layer", "retinal outer plexiform layers" ; oboInOwl:id "UBERON:0001790" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "outer plexiform layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001791 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ] . obo:UBERON_0001791 obo:IAO_0000115 "Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia)." ; obo:UBPROP_0000001 "The layer of the retina composed of the cell bodies of bipolar cells, horizontal cells, and some of the cell bodies of amacrine cells[BTO:0003176]." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:Rinl", "BTO:0003176", "EMAPA:19155", "FMA:58686", "MA:0001311", "NCIT:C32808", "NLX:93816", "NLXANAT:1005031", "SCTID:362520009", "TAO:0000119", "UMLS:C0229211", "VHOG:0001167", "Wikipedia:Inner_nuclear_layer", "XAO:0003221", "ZFA:0000119" ; oboInOwl:hasExactSynonym "inner nuclear layer", "intermediate cell layer", "neural retina inner nuclear layer", "retina inner nuclear layer", "retinal inner nuclear layer", "stratum nucleare internum", "stratum nucleare internum retinae" ; oboInOwl:hasNarrowSynonym "INL" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "layer of inner granules", "retina, inner nuclear layer" ; oboInOwl:id "UBERON:0001791" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "AO notes NLXANAT:1005031 appears to be retired" ; rdfs:label "inner nuclear layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000561 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000745 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000748 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001795 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ] . obo:UBERON_0001792 obo:IAO_0000115 "Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer." ; obo:UBPROP_0000001 "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; obo:UBPROP_0000012 "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" ; oboInOwl:hasBroadSynonym "ganglion cell layer" ; oboInOwl:hasDbXref "BAMS:Rgcl", "BTO:0003398", "CALOHA:TS-0867", "EMAPA:35739", "FMA:58687", "MA:0001310", "NCIT:C32652", "NLX:36500", "NLXANAT:1005030", "SCTID:280670002", "TAO:0000024", "VHOG:0001166", "Wikipedia:Ganglion_cell_layer", "XAO:0003223", "ZFA:0000024" ; oboInOwl:hasExactSynonym "GCL layer", "RGC layer", "ganglionic cell layer of retina", "retina ganglion cell layer", "retina ganglion layer", "retinal ganglion cell layer", "retinal ganglion layer", "stratum ganglionicum (retina)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "retina, ganglion cell layer", "stratum ganglionicum retinae" ; oboInOwl:id "UBERON:0001792" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ganglionic layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001793 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000740 ], _:genid120114 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png"^^xsd:anyURI . obo:UBERON_0001793 obo:IAO_0000115 "Layer of the retina formed by expansion of the fibers of the optic nerve." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0005888" ; oboInOwl:hasBroadSynonym "nerve fiber layer" ; oboInOwl:hasDbXref "DMBA:15652", "EMAPA:18591", "FMA:58688", "MA:0001314", "SCTID:280671003", "TAO:0002212", "VHOG:0001169", "Wikipedia:Nervous_system_fiber_layer", "XAO:0003220", "ZFA:0001619" ; oboInOwl:hasExactSynonym "layer of nerve fibers of retina", "layer of nerve fibres of retina", "optic fiber layer", "retina nerve fiber layer", "stratum neurofibrarum (retina)", "stratum neurofibrarum retinae", "stratum opticum of retina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural retina nerve fibre layer", "optic fiber layer", "optic fiber layers", "stratum neurofibrum retinae" ; oboInOwl:id "UBERON:0001793" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "nerve fiber layer of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000941 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001794 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0030424 ], _:genid120129 . obo:UBERON_0001794 obo:IAO_0000115 "The row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous[MP]." ; obo:IAO_0000116 "TODO - check frog/fish" ; obo:UBPROP_0000001 "Membrane on the apical surface of the retina. The retinal vasculature becomes adhered to the apical surface of the ILM by 30dpf[ZFIN:ZDB-PUB-071023-7, ZFIN:ZDB-PUB-120529-3]." ; oboInOwl:hasBroadSynonym "ILM" ; oboInOwl:hasDbXref "EMAPA:36519", "FMA:58689", "MA:0001313", "NCIT:C32807", "SCTID:280677004", "TAO:0001029", "UMLS:C1512783", "Wikipedia:Inner_limiting_membrane", "XAO:0003222", "ZFA:0001029" ; oboInOwl:hasExactSynonym "inner limiting membrane", "inner limiting membrane of retina", "internal limiting lamina of retina", "internal limiting membrane of retina", "retina inner limiting membrane", "retina internal limiting lamina", "stratum limitans internum retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inner limiting membranes" ; oboInOwl:id "UBERON:0001794" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "inner limiting layer of retina" ; rdfs:subClassOf obo:UBERON_0007619, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000127 ], _:genid119524, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:CL_0000636 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001797 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000966 ] . obo:UBERON_0001795 obo:IAO_0000115 "Cytoarchitectural layer of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer (adapted from Wikipedia)." ; obo:UBPROP_0000001 "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842].", "The layer within the retina where the bipolar cells synapse with the dendrites of the ganglion cells.[TAO]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; obo:UBPROP_0000012 "http://neurolex.org/wiki/Nlx_anat_1005032 appears to be retired" ; oboInOwl:hasDbXref "BAMS:Ripl", "BTO:0003175", "EMAPA:35741", "FMA:58704", "MA:0001312", "NCIT:C32809", "NLX:20558", "NLXANAT:1005032", "SCTID:280682006", "TAO:0001329", "UMLS:C0229221", "VHOG:0001168", "Wikipedia:Inner_plexiform_layer", "XAO:0003225", "ZFA:0001329" ; oboInOwl:hasExactSynonym "retina inner plexiform layer", "retinal inner plexiform layer", "stratum plexiforme internum" ; oboInOwl:hasNarrowSynonym "IPL" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inner plexiform layer", "internal plexiform layer of retina", "retina, inner plexiform layer", "retinal internal plexiform layer", "stratum plexifome internum", "stratum plexiforme internum retinae" ; oboInOwl:id "UBERON:0001795" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "inner plexiform layer of retina" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030425 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:CL_0000740 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:CL_0000748 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003902 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001781 _:genid119539 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001792 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png"^^xsd:anyURI . obo:UBERON_0001796 obo:IAO_0000115 "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." ; obo:UBPROP_0000001 "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." ; oboInOwl:hasDbXref "EHDAA2:0000139", "EHDAA:10196", "EMAPA:18232", "ENVO:02000024", "FMA:58819", "GAID:890", "MA:0001236", "MESH:D001082", "NCIT:C13190", "SCTID:280587006", "UMLS:C0003662", "VHOG:0000548", "Wikipedia:Aqueous_humor", "ZFA:0005564" ; oboInOwl:hasExactSynonym "aqueous humor", "aqueous humour", "humor aquosus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001796" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "aqueous humor of eyeball" ; rdfs:subClassOf obo:UBERON_0006312, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001766 ], _:genid120182 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001797 obo:IAO_0000115 "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." ; oboInOwl:hasBroadSynonym "portion of vitreous humor" ; oboInOwl:hasDbXref "BTO:0001451", "CALOHA:TS-0308", "EMAPA:17837", "ENVO:02000032", "EV:0100344", "FMA:58822", "MA:0001286", "NCIT:C13323", "UMLS:C0229096", "VHOG:0000795", "Wikipedia:Vitreous_humour", "ZFA:0005561" ; oboInOwl:hasExactSynonym "humor vitreous", "humor vitreus", "vitreous", "whole portion of vitreous humor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "humoral fluid", "ocular fluid", "vitreous fluid", "vitreous humour" ; oboInOwl:id "UBERON:0001797" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vitreous humor" ; rdfs:subClassOf obo:UBERON_0006312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001798 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000964 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005606 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001798 obo:IAO_0000115 "Gelatinous mucoid tissue that is composed of vitreous humor and fills the cavity behind the crystalline lens of the eye and in front of the retina[MP,modified]." ; obo:IAO_0000116 "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" ; oboInOwl:hasDbXref "CALOHA:TS-0308", "FMA:58827", "GAID:919", "MA:0002462", "MESH:D014822", "NCIT:C33884", "SCTID:181170006", "UMLS:C0042905" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001798" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "vitreous body" ; rdfs:subClassOf obo:UBERON_0011825, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001799 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001797 ], _:genid120207 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001799 obo:IAO_0000115 "The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball[BTO,modified]." ; oboInOwl:hasDbXref "BTO:0002087", "EMAPA:37805", "FMA:58848", "MA:0002461", "NCIT:C33885", "UMLS:C0229095", "Wikipedia:Vitreous_chamber" ; oboInOwl:hasExactSynonym "camera postrema", "camera postrema bulbi oculi", "camera vitrea", "camera vitrea bulbi", "postremal chamber", "postremal chamber of eyeball", "vitreous chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001799" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "vitreous chamber of eyeball" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001802 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006311 [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0001798 ] ) ] . obo:UBERON_0001800 obo:IAO_0000115 "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." ; oboInOwl:hasDbXref "AEO:0001000", "BTO:0005630", "EMAPA:36596", "FMA:5885", "MA:0002566", "MESH:D017950", "NCIT:C13060", "UMLS:C0206429" ; oboInOwl:hasExactSynonym "ganglion sensorium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001800" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sensory ganglion" ; owl:equivalentClass _:genid119604 . obo:UBERON_0001801 obo:IAO_0000115 "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." ; obo:RO_0002171 obo:UBERON_0001802 ; oboInOwl:hasDbXref "EMAPA:36594", "FMA:58865", "MA:0002484", "MESH:D000869", "NCIT:C12668", "SCTID:280658001", "UMLS:C0003153", "Wikipedia:Anterior_segment_of_eyeball", "ZFA:0005566" ; oboInOwl:hasExactSynonym "anterior eye segment", "anterior segment eye", "anterior segment of eye", "anterior segment of the eye", "eye anterior segment", "segmentum anterius (bulbus oculi)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "segmentum anterius bulbi oculi" ; oboInOwl:id "UBERON:0001801" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "anterior segment of eyeball" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid120234, _:genid120236 ; owl:disjointWith obo:UBERON_0001802 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png"^^xsd:anyURI . obo:UBERON_0001802 obo:IAO_0000115 "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." ; oboInOwl:hasDbXref "EMAPA:36595", "FMA:58868", "MA:0002485", "NCIT:C12906", "SCTID:280659009", "UMLS:C0278450", "Wikipedia:Posterior_segment_of_eyeball", "ZFA:0005567" ; oboInOwl:hasExactSynonym "eye posterior segment", "posterior eye segment", "posterior segment eye", "posterior segment of eye", "posterior segment of the eye", "segmentum posterius (bulbus oculi)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "segmentum posterius bulbi oculi" ; oboInOwl:id "UBERON:0001802" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "posterior segment of eyeball" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid120245, _:genid120247 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0001803 obo:IAO_0000115 "A layer of epithelial cells that is part of the eye." ; obo:IAO_0000232 "this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former" ; oboInOwl:hasDbXref "BTO:0001873", "CALOHA:TS-0543", "EMAPA:32871", "FMA:58871", "MA:0001301", "SCTID:362523006", "TAO:0001326", "Wikipedia:Lens_(anatomy)#Lens_Epithelium", "XAO:0004094", "ZFA:0001326" ; oboInOwl:hasExactSynonym "epithelial tissue of eye lens", "epithelial tissue of lens", "epithelium lentis", "epithelium of eye lens", "eye lens epithelial tissue", "eye lens epithelium", "lens epithelial tissue", "lens epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001803" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "epithelium of lens" ; rdfs:subClassOf obo:UBERON_0000484, _:genid119631, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000965 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ] ) ] . obo:UBERON_0001804 obo:IAO_0000115 "The elastic, clear, membrane-like structure, that is outer most layer of the lens." ; obo:UBPROP_0000001 "The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" ; obo:UBPROP_0000010 "synthesized by the lens epithelium and its main components are Type IV collagen and sulfated glycosaminoglycans (GAGs). [Wikipedia:Capsule_of_lens" ; obo:UBPROP_0000012 "FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular" ; oboInOwl:hasDbXref "EHDAA2:0000977", "EMAPA:18237", "FMA:58881", "MA:0001300", "NCIT:C32975", "SCTID:244500004", "UMLS:C0229232", "VHOG:0000550", "Wikipedia:Lens_(anatomy)#Lens_capsule", "ZFA:0005574" ; oboInOwl:hasExactSynonym "capsula lentis", "lens capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001804" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "capsule of lens" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_35722 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005587 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000964 ], _:genid120275, _:genid120277 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid119642 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png"^^xsd:anyURI . obo:UBERON_0001805 obo:IAO_0000115 "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." ; oboInOwl:hasDbXref "AEO:0001001", "CALOHA:TS-2340", "EMAPA:17157", "EMAPA:18221", "FMA:5889", "MA:0000220", "MESH:D005725", "NCIT:C12720", "UMLS:C0017068", "Wikipedia:Autonomic_ganglion" ; oboInOwl:hasExactSynonym "autonomic nervous system ganglion", "ganglion of autonomic nervous system", "ganglion of visceral nervous system", "visceral nervous system ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglion autonomicum" ; oboInOwl:id "UBERON:0001805" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "autonomic ganglion" ; rdfs:subClassOf obo:UBERON_0000045, [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0034728 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid119657 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png"^^xsd:anyURI . obo:UBERON_0001806 obo:IAO_0000115 "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." ; oboInOwl:hasDbXref "AAO:0010773", "BTO:0001333", "CALOHA:TS-0994", "EHDAA2:0001969", "EMAPA:17157", "FMA:5890", "MA:0000226", "MESH:D005728", "NCIT:C12467", "SCTID:362485003", "UMLS:C0017071", "Wikipedia:Sympathetic_ganglion" ; oboInOwl:hasExactSynonym "ganglion of sympathetic nervous system", "ganglion of sympathetic part of autonomic division of nervous system", "ganglion sympatheticum", "sympathetic nervous system ganglion", "sympathetic part of autonomic division of nervous system ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglion sympathicum" ; oboInOwl:id "UBERON:0001806" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sympathetic ganglion" ; rdfs:subClassOf obo:UBERON_0001805, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000013 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0034729 ], _:genid120301 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid119669 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png"^^xsd:anyURI . obo:UBERON_0001808 obo:IAO_0000115 "Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands." ; oboInOwl:hasDbXref "BTO:0001256", "EHDAA2:0001400", "EMAPA:32813", "FMA:5894", "MA:0002469", "MESH:D005726", "NCIT:C52557", "NLXANAT:100303", "SCTID:279284004", "UMLS:C0017069", "Wikipedia:Parasympathetic_ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglion parasympathicum" ; oboInOwl:id "UBERON:0001808" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "parasympathetic ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000011 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0004293 ], _:genid120316 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001805 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000011 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png"^^xsd:anyURI . obo:UBERON_0001809 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "EMAPA:35312", "FMA:5896", "MA:0001144", "NCIT:C52709", "UMLS:C0501399", "Wikipedia:Enteric_ganglia" ; oboInOwl:hasExactSynonym "intramural ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001809" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "enteric ganglion" ; rdfs:subClassOf obo:UBERON_0001808, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001808 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:UBERON_0001810 obo:IAO_0000115 "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." ; obo:UBPROP_0000012 "Made to be a subtype of junction rather than tissue to be consistent with FMA" ; oboInOwl:hasBroadSynonym "plexus" ; oboInOwl:hasDbXref "AEO:0000138", "BTO:0000205", "EHDAA2:0003138", "EHDAA:3780", "EMAPA:37683", "FMA:5901", "MA:0002407", "NCIT:C12929", "SCTID:122455009", "UMLS:C0501403", "Wikipedia:Nervous_system_plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001810" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "nerve plexus" ; rdfs:subClassOf obo:UBERON_0007651, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ], _:genid120333, _:genid120335 . obo:UBERON_0001811 obo:IAO_0000115 "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." ; obo:UBPROP_0000007 "conjunctival" ; oboInOwl:hasDbXref "AAO:0010343", "BTO:0003415", "CALOHA:TS-2232", "EFO:0000374", "EMAPA:18233", "EV:0100340", "FMA:59011", "GAID:898", "MA:0000265", "MESH:D003228", "NCIT:C12341", "SCTID:181161008", "UMLS:C0009758", "Wikipedia:Conjunctiva", "XAO:0000182" ; oboInOwl:hasExactSynonym "conjunctivae", "conjunctivas", "tunica conjunctiva", "wall of conjunctival sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001811" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "conjunctiva" ; rdfs:subClassOf obo:UBERON_0000060, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001711 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001773 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001801 ], _:genid120342, _:genid120344, _:genid120346 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png"^^xsd:anyURI . obo:UBERON_0001812 obo:IAO_0000115 "A thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies." ; oboInOwl:hasDbXref "FMA:59025", "MA:0001265", "NCIT:C12901", "SCTID:280666005", "UMLS:C0229274" ; oboInOwl:hasExactSynonym "conjunctival layer of eyelids", "tarsal conjunctiva", "tunica conjunctiva palpebrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eyelid conjunctiva" ; oboInOwl:id "UBERON:0001812" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "lines the eyeballs" ; rdfs:label "palpebral conjunctiva" ; rdfs:subClassOf obo:UBERON_0010305, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0010306 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001711 ], _:genid120358 . obo:UBERON_0001813 obo:IAO_0000115 "An intermingling of fiber fascicles from adjacent spinal nerves to form a network." ; obo:UBPROP_0000003 "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001899", "EMAPA:16987", "FMA:5903", "MA:0000235", "NCIT:C49601", "SCTID:42280003", "UMLS:C0228603", "VHOG:0000925" ; oboInOwl:hasExactSynonym "plexus nervorum spinalium", "plexus of spinal nerves", "somatic nerve plexus", "spinal nerve plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001813" ; a owl:Class ; rdfs:label "spinal nerve plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001810 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001780 ] ) ] . obo:UBERON_0001814 obo:IAO_0000115 "An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]." ; obo:IAO_0000116 "check superclass - nerve vs collection of fibers vs junction; note that FMA also has 'brachial autonomic nerve plexus'" ; obo:UBPROP_0000001 "A nerve plexus originating from the anterior branches of the last four cervical and the first thoracic spinal nerves, giving off many of the principal nerves of the shoulder, chest, and arms. [TFD][VHOG]" ; obo:UBPROP_0000003 "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000180", "EHDAA:3782", "EMAPA:16988", "FMA:5906", "GAID:842", "MA:0001180", "MESH:D001917", "NCIT:C12682", "SCTID:181002002", "UMLS:C0006090", "VHOG:0000372", "Wikipedia:Brachial_plexus" ; oboInOwl:hasExactSynonym "brachial plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus brachialis" ; oboInOwl:id "UBERON:0001814" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "brachial nerve plexus" ; rdfs:subClassOf obo:UBERON_0001813, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002102 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c9/Brachial_plexus_color.svg"^^xsd:anyURI . obo:UBERON_0001815 obo:IAO_0000115 "An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle." ; oboInOwl:hasDbXref "BAMS:lsp", "EHDAA2:0001040", "EHDAA:4673", "EMAPA:17587", "FMA:5907", "GAID:849", "MA:0001181", "MESH:D008160", "NCIT:C52805", "SCTID:181049003", "UMLS:C0024093", "VHOG:0000926", "Wikipedia:Lumbosacral_plexus" ; oboInOwl:hasExactSynonym "lumbosacral plexus", "plexus lumbosacralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus lumbosacralis" ; oboInOwl:id "UBERON:0001815" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "lumbosacral nerve plexus" ; rdfs:subClassOf obo:UBERON_0001813, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002103 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png"^^xsd:anyURI . obo:UBERON_0001816 obo:IAO_0000115 "A nerve plexus that is part of an autonomic nervous system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18224", "FMA:5910", "MA:0000221", "SCTID:362482000" ; oboInOwl:hasExactSynonym "autonomic plexus", "plexus autonomicus", "plexus nervosus visceralis", "plexus visceralis", "visceral nerve plexus", "visceral plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001816" ; a owl:Class ; rdfs:label "autonomic nerve plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001810 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002410 ] ) ] . obo:UBERON_0001817 obo:IAO_0000115 "The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP]." ; obo:UBPROP_0000001 "Lobular organ the parenchyma of which consists of glandular acini which communicate the lacrimal sac. Examples: There only two instances, right lacrimal and left lacrimal glands.", "The preorbital gland is a paired exocrine gland found in many species of hoofed animals, which is homologous to the lacrimal gland found in humans. These glands are trenchlike slits of dark blue to black, nearly bare skin extending from the medial canthus of each eye. They are lined by a combination of sebaceous and sudoriferous glands, and they produce secretions which contain pheromones and other semiochemical compounds. Ungulates frequently deposit these secretions on twigs and grass as a means of communication with other animals. The preorbital gland serves different roles in different species. Pheromone-containing secretions from the preorbital gland may serve to establish an animal's dominance (especially in preparation for breeding), mark its territory, or simply to produce a pleasurable sensation to the animal. Because of its critical role in scent marking, the preorbital gland is usually considered as a type of scent gland. A further function of these glands may be to produce antimicrobial compounds against skin pathogens. Antimicrobial compounds found in these glands may be biosynthesized by the animal itself, or by microorganisms that live in these glands[Wikipedia:Preorbital_gland]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In humans, they are situated in the upper, outer portion of each orbit", "Innervation is highly complex and species-specific" ; oboInOwl:hasDbXref "BTO:0000044", "CALOHA:TS-0512", "EFO:0001389", "EMAPA:35463", "EV:0100339", "FMA:59101", "MA:0001296", "NCIT:C12346", "SCTID:181147003", "UMLS:C0022907", "VHOG:0001476", "Wikipedia:Lacrimal_gland", "Wikipedia:Preorbital_gland" ; oboInOwl:hasExactSynonym "glandula lacrimalis", "lacrimal-preorbital gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula praeorbitalis", "preorbital gland", "tear gland" ; oboInOwl:id "UBERON:0001817" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lacrimal gland" ; rdfs:subClassOf obo:UBERON_0015154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0022284 ], _:genid119766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001750 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png"^^xsd:anyURI . obo:UBERON_0001818 obo:IAO_0000115 "A modified lobulated sebaceous gland at the rim of an eyelid, responsible for the supply of meibum." ; obo:UBPROP_0000011 "in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening[PMID:20664693]" ; oboInOwl:hasDbXref "BTO:0004165", "FMA:59104", "GAID:899", "MA:0001249", "MESH:D008537", "NCIT:C33075", "SCTID:280585003", "UMLS:C0025181", "Wikipedia:Meibomian_gland" ; oboInOwl:hasExactSynonym "Meibomian gland", "gland of Meibom", "glandula tarsales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palpebral gland", "tarsoconjunctival gland" ; oboInOwl:id "UBERON:0001818" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tarsal gland" ; rdfs:subClassOf obo:UBERON_0015251, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001711 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004772 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray1205.png"^^xsd:anyURI . obo:UBERON_0001819 obo:IAO_0000115 "Orifice separating upper and lower eyelids. In the human adult this measures about 10mm vertically and 30 mm horizontally. It can be reduced in size in fetal alcohol syndrome. In Trisomy 9 the palpebral fissures can be upslanting. [WP,modified]." ; oboInOwl:hasDbXref "FMA:59110", "MA:0001266", "SCTID:280576003", "Wikipedia:Palpebral_fissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rima palpebrarum" ; oboInOwl:id "UBERON:0001819" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "palpebral fissure" ; rdfs:subClassOf obo:UBERON_0000161, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005611 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0006726 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001712 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001713 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray892.png"^^xsd:anyURI . obo:UBERON_0001820 obo:IAO_0000115 "Any of the coil glands of the skin that secrete sweat." ; obo:IAO_0000116 "TODO - check if all sweat glands are epidermal - see EMAPA:29743" ; obo:UBPROP_0000001 "A gland that secretes sweat, found in the dermis or subcutaneous tissue, opening by a duct on the body surface. [TFD][VHOG]" ; obo:UBPROP_0000003 "Sweat glands (also called sudoriferous glands) are unique to mammals.[well established][VHOG]" ; obo:UBPROP_0000008 "In humans a system of apocrine - and merocrine sweat glands is the main method of cooling. Many other mammals rely on panting or other means as a primary source of cooling, but still use sweat glands to aid in body temperature regulation" ; oboInOwl:hasDbXref "BTO:0001331", "CALOHA:TS-0993", "EMAPA:35844", "EV:0100160", "FMA:59152", "GAID:943", "MA:0000150", "MESH:D013545", "NCIT:C33712", "SCTID:361700009", "UMLS:C0038989", "VHOG:0001467", "Wikipedia:Sweat_gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula sudorifera", "sudoriferous gland", "sudoriparous gland" ; oboInOwl:id "UBERON:0001820" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sweat gland" ; rdfs:subClassOf obo:UBERON_0002365, _:genid120437, _:genid120439, _:genid120441 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001089 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg"^^xsd:anyURI . obo:UBERON_0001821 obo:IAO_0000115 "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." ; obo:IAO_0000232 "sebaceous glands are also found in glabrous areas of eyelids, nose, penis, labia minora and nipples, and do not always secrete into hair follices. This causes some confusion in classification. In addition some structures, such as preputial glands are sometimes called 'modified' sebaceous glands, implying a non-subclass relationship. we follow MP and MA in keeping this class generic and creating a distinct subclass for sebaceuous glands of the skin. The FMA class may be better placed under this subclass." ; obo:UBPROP_0000001 "Any of the numerous holocrine glands in the dermis that empty into a hair follicle and produce and secrete sebum. [TFD][VHOG]" ; obo:UBPROP_0000003 "Sebaceous glands are also limited to mammals.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001980", "CALOHA:TS-2384", "EMAPA:35754", "EV:0100161", "FMA:59160", "GAID:900", "MA:0002565", "MESH:D012627", "NCIT:C33519", "SCTID:361697005", "UMLS:C0036505", "VHOG:0001468", "Wikipedia:Sebaceous_gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula sebacea", "glandula sebaceae", "sebaceous follicle" ; oboInOwl:id "UBERON:0001821" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sebaceous gland" ; rdfs:subClassOf obo:UBERON_0012344, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011932 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001866 ], _:genid120451, _:genid120455 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/HairFollicle.png"^^xsd:anyURI . obo:UBERON_0001823 obo:IAO_0000115 "One of the cartilage structures in the nose that provide form and support[WP]." ; oboInOwl:hasDbXref "CALOHA:TS-0655", "EMAPA:37681", "FMA:59502", "MA:0001883", "MESH:D055171", "NCIT:C49593", "SCTID:278941001", "UMLS:C0225415", "Wikipedia:Nasal_cartilage" ; oboInOwl:hasExactSynonym "cartilage of nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001823" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "nasal cartilage" ; rdfs:subClassOf obo:UBERON_0002418, [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000402 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png"^^xsd:anyURI . obo:UBERON_0001824 obo:IAO_0000115 "The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx." ; oboInOwl:hasDbXref "EMAPA:18334", "FMA:59662", "GAID:301", "MA:0001766", "MESH:D007820", "NCIT:C49246", "SCTID:361940006", "UMLS:C0023053" ; oboInOwl:hasExactSynonym "laryngeal mucosa", "larynx mucosa", "larynx mucosa of organ", "larynx mucous membrane", "larynx organ mucosa", "mucosa of organ of larynx", "mucous membrane of larynx", "organ mucosa of larynx", "tunica mucosa laryngis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laryngeal mucous membrane" ; oboInOwl:id "UBERON:0001824" ; a owl:Class ; rdfs:label "mucosa of larynx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0001825 obo:IAO_0000115 "The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity." ; obo:UBPROP_0000011 "Arise as epithelial lined diverticula of the lining of the nasal cavity. The extent of sinus development varies with species, most of the development occurs postnatally" ; obo:UBPROP_0000202 obo:FMA_76587 ; oboInOwl:hasBroadSynonym "sinus" ; oboInOwl:hasDbXref "CALOHA:TS-2082", "EHDAA:6489", "EMAPA:35662", "EV:0100038", "FMA:59679", "GAID:355", "MA:0000431", "MESH:D010256", "NCIT:C12763", "SCTID:181203001", "UMLS:C0030471", "Wikipedia:Paranasal_sinuses" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal sinus" ; oboInOwl:id "UBERON:0001825" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "paranasal sinus" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg"^^xsd:anyURI . obo:UBERON_0001826 obo:IAO_0000115 "The mucous membrane that lines the nasal cavity[MP]." ; obo:IAO_0000116 "TODO - check lining vs part of. split olfactory and nasal mucosa?" ; oboInOwl:hasDbXref "BTO:0000912", "CALOHA:TS-0657", "EMAPA:36026", "FMA:59684", "GAID:302", "SCTID:310211009", "Wikipedia:Mucous_membrane_of_nose" ; oboInOwl:hasExactSynonym "mucosa of nose", "mucous membrane of nose", "tunica mucosa nasalis", "tunica mucosa nasi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal mucosa" ; oboInOwl:id "UBERON:0001826" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasal cavity mucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0015788 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015788 ] ) ] . obo:UBERON_0001827 obo:IAO_0000115 "Aqueous substance secreted by the lacrimal gland." ; oboInOwl:hasDbXref "BTO:0001499", "CALOHA:TS-1016", "EMAPA:36537", "ENVO:02000034", "FMA:59756", "GAID:1173", "MA:0002508", "MESH:D013666", "NCIT:C33739", "UMLS:C0039409", "Wikipedia:Tear", "galen:Tear", "galen:Tears" ; oboInOwl:hasExactSynonym "lacrimal fluid", "lacrimal gland secretion", "lacrimal secretion", "tear", "tears" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tear fluid" ; oboInOwl:id "UBERON:0001827" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "secretion of lacrimal gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000009978 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001817 ] ) ] . obo:UBERON_0001828 obo:IAO_0000115 "The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001]." ; obo:IAO_0000116 "FMA has a 3-level breakdown of jaws into: region, jaw (skeleton+gums), skeleton." ; obo:UBPROP_0000007 "gingival" ; oboInOwl:hasDbXref "BTO:0000519", "CALOHA:TS-2074", "EFO:0001925", "EMAPA:35945", "EV:0100064", "FMA:59762", "GAID:1257", "MA:0000342", "MESH:D005881", "NCIT:C32677", "SCTID:181224006", "UMLS:C0017562", "VHOG:0001269", "Wikipedia:Gingiva", "galen:Gingiva" ; oboInOwl:hasExactSynonym "gum", "gum tissue", "gums" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gingival mucosa" ; oboInOwl:id "UBERON:0001828" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gingiva" ; rdfs:subClassOf obo:UBERON_0000344, _:genid119872, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004103 ], _:genid119874, _:genid120514, _:genid120517 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg"^^xsd:anyURI . obo:UBERON_0001829 obo:IAO_0000115 "One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands." ; obo:UBPROP_0000008 "There are 3 pairs of major salivary glands in human and mouse" ; oboInOwl:hasDbXref "FMA:59788", "MA:0002478", "NCIT:C12999", "SCTID:303049006", "UMLS:C0930553", "galen:MajorSalivaryGland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001829" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "major salivary gland" ; rdfs:subClassOf obo:UBERON_0001044, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000165 ] . obo:UBERON_0001831 obo:IAO_0000115 "The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted]." ; obo:UBPROP_0000001 "A mammalian salivary gland located caudal to the ear. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-22, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010095", "BTO:0001004", "CALOHA:TS-0748", "EFO:0002558", "EMAPA:18537", "EV:0100060", "FMA:59790", "GAID:938", "MA:0001585", "MESH:D010306", "NCIT:C12427", "SCTID:181234002", "UMLS:C0030580", "VHOG:0000308", "Wikipedia:Parotid_gland", "galen:ParotidGland" ; oboInOwl:hasExactSynonym "parotid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula parotidea" ; oboInOwl:id "UBERON:0001831" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The mouse parotid, exorbital lacrimal gland and exocrine pancreas have similar histological appearances[ISBN:0123813611]" ; rdfs:label "parotid gland" ; rdfs:subClassOf obo:UBERON_0000409, obo:UBERON_0001829, _:genid119885, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008801 ], _:genid120530 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg"^^xsd:anyURI . obo:UBERON_0001832 obo:IAO_0000115 "The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland." ; obo:UBPROP_0000001 "One of a pair of small salivary glands situated under the mucous membrane of the floor of the mouth, beneath the tongue. [TFD][VHOG]" ; obo:UBPROP_0000003 "Most mammals have well-developed parotid, mandibular, and sublingual glands.[well established][VHOG]" ; obo:UBPROP_0000008 "Single lobed in mouse; largest acini of the 3 rodent salivary glands. In human and mouse, secretions are predominantly mucinous" ; oboInOwl:hasDbXref "BTO:0001315", "CALOHA:TS-0987", "EMAPA:18809", "EV:0100062", "FMA:59791", "GAID:941", "MA:0001588", "MESH:D013361", "NCIT:C12234", "SCTID:362176005", "UMLS:C0038553", "VHOG:0000363", "Wikipedia:Sublingual_gland" ; oboInOwl:hasExactSynonym "Rivinus' gland", "ductus sublingualis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Rivinus gland", "glandula sublingualis", "sublingual salivary gland", "submaxillary gland" ; oboInOwl:id "UBERON:0001832" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sublingual gland" ; rdfs:subClassOf obo:UBERON_0001829, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006297 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png"^^xsd:anyURI . obo:UBERON_0001833 obo:IAO_0000115 "One of the two fleshy folds which surround the opening of the mouth." ; obo:UBPROP_0000001 "Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO]" ; obo:UBPROP_0000007 "labial" ; oboInOwl:hasDbXref "BTO:0001647", "CALOHA:TS-0558", "EMAPA:32839", "FMA:59816", "GAID:76", "MA:0000343", "MESH:D008046", "NCIT:C12220", "SCTID:181221003", "TAO:0007006", "UMLS:C0023759", "VHOG:0000677", "Wikipedia:Lip", "ZFA:0007006", "galen:Lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labia oris", "lips" ; oboInOwl:id "UBERON:0001833" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lip" ; rdfs:subClassOf obo:UBERON_0003102, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000165 ], _:genid120549, _:genid120551 ; owl:disjointWith obo:UBERON_0004084 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg"^^xsd:anyURI . obo:UBERON_0001834 obo:IAO_0000115 "Lip that covers the upper portion of the mouth.[TAO]." ; obo:UBPROP_0000001 "Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG]", "Lip that covers the upper portion of the mouth.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0003391" ; oboInOwl:hasDbXref "EMAPA:17925", "FMA:59817", "MA:0000919", "SCTID:245776003", "TAO:0001970", "VHOG:0001750", "Wikipedia:Upper_lip", "ZFA:0005226" ; oboInOwl:hasExactSynonym "upper jaw lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labium superius oris" ; oboInOwl:id "UBERON:0001834" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "upper lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0011592 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001833 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg"^^xsd:anyURI . obo:UBERON_0001835 obo:IAO_0000115 "Lip that covers the lower portion of the mouth.[TAO]." ; obo:UBPROP_0000001 "Lip that covers the lower portion of the mouth.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0003392" ; oboInOwl:hasDbXref "EHDAA2:0001020", "EMAPA:17909", "FMA:59818", "MA:0000921", "NCIT:C94572", "SCTID:245777007", "TAO:0002060", "UMLS:C0458583", "Wikipedia:Lower_lip", "ZFA:0005225" ; oboInOwl:hasExactSynonym "lower jaw lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labium inferius oris" ; oboInOwl:id "UBERON:0001835" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lower lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011596 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001833 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg"^^xsd:anyURI . obo:UBERON_0001836 obo:IAO_0000115 "A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions." ; obo:UBPROP_0000007 "salivary" ; obo:UBPROP_0000008 "We classify a wide variety of not necessarily homologous fluids here. In humans, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin" ; oboInOwl:hasDbXref "BTO:0001202", "CALOHA:TS-0891", "EMAPA:36536", "ENVO:02000036", "FMA:59862", "GAID:1167", "MA:0002507", "MAT:0000444", "MESH:D012463", "NCIT:C13275", "UMLS:C0036087", "Wikipedia:Saliva", "galen:Saliva" ; oboInOwl:hasExactSynonym "salivary gland secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sailva normalis", "saliva atomaris", "saliva molecularis" ; oboInOwl:id "UBERON:0001836" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "saliva" ; rdfs:subClassOf obo:UBERON_0000456, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007586 ] . obo:UBERON_0001837 obo:IAO_0000115 "The duct of a salivary gland." ; oboInOwl:hasDbXref "BTO:0005115", "EMAPA:35750", "FMA:59908", "GAID:939", "MA:0001586", "MESH:D018987", "NCIT:C32486", "SCTID:181238004", "Wikipedia:Salivary_duct" ; oboInOwl:hasExactSynonym "salivary duct", "salivary gland duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "secretory duct" ; oboInOwl:id "UBERON:0001837" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "duct of salivary gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001044 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001836 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001044 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0001838 obo:IAO_0000115 "A duct of a sublingual gland." ; oboInOwl:hasDbXref "BTO:0004558", "EMAPA:36564", "FMA:59983", "MA:0002699", "SCTID:281000009", "Wikipedia:Sublingual_duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001838" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sublingual duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001832 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001832 ] ; owl:equivalentClass _:genid119949 . obo:UBERON_0001839 obo:IAO_0000115 "A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." ; oboInOwl:hasDbXref "AAO:0011078", "BTO:0004685", "CALOHA:TS-2080", "EMAPA:36580", "EV:0100362", "FMA:60179", "MA:0000238", "NCIT:C33227", "SCTID:279727008", "UMLS:C0458699", "VHOG:0001219", "Wikipedia:Bony_labyrinth", "XAO:0000193" ; oboInOwl:hasExactSynonym "osseous labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labyrinthus osseus", "osseus labyrinth" ; oboInOwl:id "UBERON:0001839" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Ideally we would place a spatially disjoint from relationship to membranous labyrinth, but there are many parts in common. this should be resolved." ; rdfs:label "bony labyrinth" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004681 ], _:genid120603, _:genid120605 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray920.png"^^xsd:anyURI . obo:UBERON_0001840 obo:IAO_0000115 "One of three half-circular, interconnected tubes located inside each ear[WP]." ; obo:UBPROP_0000001 "Fluid-filled toroidal spaces, arranged orthogonally to each other in the ear, that detect angular accelerations. (See Anatomical Atlas entry for semicircular canals by T. Whitfield.)[TAO]" ; obo:UBPROP_0000003 "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. These ducts are sometimes called canals, but technically the term semicircular canal applies to the spaces in the osseus labyrinth in which the semicircular ducts lie.[uncertain][VHOG]" ; obo:UBPROP_0000009 "detects angular acceleration" ; obo:UBPROP_0000012 "MA divides this into osseous and duct. In FMA, this is systemically part of the bony labyrinth. Note this is an anatomical space in ZFA. The MA treatment has advantages for representing the neuroepithelium, which should not be part of bone. Also check duct vs canal" ; oboInOwl:hasDbXref "AAO:0011098", "BTO:0003383", "CALOHA:TS-2164", "EMAPA:32832", "EV:0100365", "FMA:60186", "GAID:776", "MA:0000249", "MESH:D012665", "NCIT:C33527", "SCTID:279757004", "TAO:0000431", "UMLS:C0036622", "VHOG:0001144", "Wikipedia:Semicircular_canal", "XAO:0000198", "ZFA:0000431" ; oboInOwl:hasExactSynonym "semicircular canals" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis semicircularis", "ductus semicirculares", "scc", "semicircular ducts" ; oboInOwl:id "UBERON:0001840" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "semicircular canal" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003051 ], _:genid120612, _:genid120614 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Balance_Disorder_Illustration_A.png"^^xsd:anyURI . obo:UBERON_0001844 obo:IAO_0000115 "The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified]." ; obo:UBPROP_0000001 "A spiral-shaped cavity in the petrous portion of the temporal bone of the inner ear, containing the nerve endings essential for hearing and forming one of the divisions of the labyrinth. [TFD][VHOG]" ; obo:UBPROP_0000003 "Because achieving high sensitivity is generally advantageous for auditory organs, it is not surprising that evidence for cochlear amplification is also seen in nonmammals. Spontaneous otoacoustic emissions (SOAEs) are narrow-band sound signals emitted from the inner ear, and it is generally assumed that their energy derives from the hair-cell molecular motors underlying cochlear amplification. However, all terrestrial vertebrates studied so far (including amphibians) show very similar SOAEs. The most parsimonious explanation for the universality of this phenomena is that some kind of amplifying mechanism is at least as old as land vertebrates themselves.[well established][VHOG]" ; obo:UBPROP_0000007 "cochlear" ; obo:UBPROP_0000008 "The association with 'lagena' in frog and fish comes from HOG, although HOG is inconsistent here, associating lagena with XAO cochlea and ZFA cochlear duct. NBK53175 says: 'In contrast, the ventrally located auditory chambers have undergone more extensive evolutionary modifications. The saccule and lagena are prominent auditory organs in fish but the saccule has a vestibular role in mammals and birds, and the lagena is absent in mammals. The primary au- ditory organ in mammals and birds is the cochlea, which has no known counterpart in amphibians and fish (Riley and Phillips, 2003)'", "the cochlea is coiled in most mammals, monotremes being the exceptions." ; obo:UBPROP_0000012 "sources vary in connection to bony labyrinth" ; oboInOwl:hasDbXref "AAO:0000253", "BIRNLEX:1190", "BTO:0000267", "CALOHA:TS-0151", "EFO:0000357", "EMAPA:17597", "EV:0100363", "FMA:60201", "GAID:724", "MA:0000240", "MAT:0000144", "MESH:D003051", "MIAA:0000144", "NCIT:C12395", "NIFSTD_RETIRED:birnlex_883", "SCTID:181187008", "TAO:0000374", "UMLS:C0009195", "UMLS:C1278895", "VHOG:0000691", "Wikipedia:Cochlea", "XAO:0000197", "ZFA:0000374" ; oboInOwl:hasExactSynonym "cochlear part of bony labyrinth", "lagena" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cochleae", "cochlear duct", "cochlear organ", "lagenas" ; oboInOwl:id "UBERON:0001844" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cochlea" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001846 ], _:genid120627 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg"^^xsd:anyURI . obo:UBERON_0001846 obo:IAO_0000115 "Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation." ; obo:UBPROP_0000001 "The auditory (hearing) and vestibular (balance) organ of the fish, equivalent to the inner ear of amniotes. (See Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" ; obo:UBPROP_0000003 "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000238", "BIRNLEX:1196", "BTO:0000630", "CALOHA:TS-0478", "EFO:0001363", "EHDAA2:0000831", "EHDAA:504", "EMAPA:16194", "EV:0100361", "FMA:60909", "GAID:871", "MA:0000237", "MAT:0000145", "MESH:D007758", "MIAA:0000145", "NCIT:C12499", "SCTID:181189006", "SCTID:304982002", "TAO:0000217", "UMLS:C0022889", "UMLS:C1268973", "VHOG:0000284", "Wikipedia:Internal_ear", "XAO:0000192", "ZFA:0000217", "galen:InnerEar" ; oboInOwl:hasExactSynonym "inner ear" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auris interna", "labyrinth", "otocyst" ; oboInOwl:id "UBERON:0001846" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "internal ear" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ], _:genid120641 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png"^^xsd:anyURI . obo:UBERON_0001847 obo:IAO_0000115 "The soft lower part of the external ear, projecting below the antitragus." ; obo:UBPROP_0000010 "The earlobe is composed of tough areolar and adipose (fatty) connective tissues, lacking the firmness and elasticity of the rest of the pinna. Since the earlobe does not contain cartilage the earlobe has a large blood supply and may help to warm the ears and maintain balance but generally earlobes are not considered to have any major biological function." ; oboInOwl:hasDbXref "FMA:60984", "MA:0002468", "NCIT:C32999", "SCTID:362544006", "UMLS:C0229315", "Wikipedia:Ear_lobe" ; oboInOwl:hasExactSynonym "auricular lobule", "ear lobe", "earlobe", "lobe of ear", "lobule of auricle of ear", "lobulus auriculae", "pinna lobule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ear lobule", "lobule of auricle" ; oboInOwl:id "UBERON:0001847" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lobule of pinna" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001013 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006815 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001691 ] . obo:UBERON_0001848 obo:IAO_0000115 "Cartilage of the pinna and much of the external ear canal." ; oboInOwl:hasDbXref "EMAPA:35158", "FMA:61013", "MA:0001227", "SCTID:279627003" ; oboInOwl:hasExactSynonym "cartilage of pinna", "pinna cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001848" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "auricular cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001867 ] ) ] . obo:UBERON_0001849 obo:IAO_0000115 "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP]." ; obo:UBPROP_0000001 "A system of communicating epithelial sacs and ducts within the bony labyrinth, containing the endolymph. [TFD][VHOG]" ; obo:UBPROP_0000003 "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" ; obo:UBPROP_0000012 "inner ear has parts membranous and osseuous/bony labyrinth. it's not clear where the EMAPA term 'labyrinth' belong, we place them here for now" ; oboInOwl:hasAlternativeId "UBERON:0010113" ; oboInOwl:hasDbXref "AAO:0011060", "EHDAA2:0000899", "EHDAA:4698", "EMAPA:17815", "EV:0100367", "FMA:61022", "MA:0000242", "NCIT:C33090", "SCTID:263790009", "UMLS:C0458700", "VHOG:0000729", "Wikipedia:Membranous_labyrinth", "XAO:0000194" ; oboInOwl:hasExactSynonym "labyrinthus membranaceus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001849" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "membranous labyrinth" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004637 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003051 ], _:genid120665 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray924.png"^^xsd:anyURI . obo:UBERON_0001850 obo:IAO_0000115 "A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct." ; obo:IAO_0000116 "TODO - resolve lacrimal canaliculus vs larcimal duct" ; obo:UBPROP_0000008 "chelonians lack a lacrimal duct, and lacrimal/harderian secretions remain in or spill from the conjunctival sac[PMID:7559104]" ; oboInOwl:hasDbXref "EMAPA:19245", "FMA:61063", "MA:0001295", "SCTID:280426002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lacrimal duct", "tear duct" ; oboInOwl:id "UBERON:0001850" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lacrimal drainage system" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010284 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001827 ], _:genid120676 . obo:UBERON_0001851 obo:IAO_0000115 "Outermost layer of an organ[WP]." ; obo:UBPROP_0000007 "cortical" ; obo:UBPROP_0000012 "this class is used more generically than in FMA, and includes e.g. cortex of hair" ; oboInOwl:hasDbXref "EFO:0000383", "EHDAA:9344", "FMA:61109", "Wikipedia:Cortex_(anatomy)", "galen:Cortex" ; oboInOwl:hasExactSynonym "cortex", "cortex of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001851" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "cortex" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000062 ] . obo:UBERON_0001855 obo:IAO_0000115 "An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." ; obo:IAO_0000116 "TODO - check cochlear duct vs cochlear aqueduct vs scala media" ; obo:UBPROP_0000001 "The coiled portion of the membranous labyrinth located inside the cochlea. It contains endolymph. [TFD][VHOG]" ; obo:UBPROP_0000003 "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. (...) In all gnathostomes, the utriculus connects ventrally with a larger sac, called the sacculus (...) In most groups of gnathostomes, the caudoventral evagination of the sacculus forms a small lagena, and in some diapsids and mammals the lagena develops into a longer duct. The lagena becomes greatly elongated in therians and coils to form the cochlear duct.[well established][VHOG]" ; oboInOwl:hasDbXref "BIRNLEX:2562", "BTO:0001692", "CALOHA:TS-0152", "EHDAA2:0000262", "EHDAA:4718", "EMAPA:17598", "FMA:61119", "GAID:874", "MA:0000243", "MESH:D003053", "NCIT:C32335", "SCTID:279849006", "UMLS:C1281166", "UMLS:C1323110", "VHOG:0000507", "Wikipedia:Cochlear_duct" ; oboInOwl:hasExactSynonym "Reissner's canal", "Reissners canal", "cochlea duct", "cochlear duct", "scala medias" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cochlear aqueduct", "ductus cochlearis", "membranous cochlea", "scala media", "scala of Loewenberg" ; oboInOwl:id "UBERON:0001855" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cochlear duct of membranous labyrinth" ; rdfs:subClassOf obo:UBERON_0000025, _:genid120688 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png"^^xsd:anyURI . obo:UBERON_0001862 obo:IAO_0000115 "The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals." ; oboInOwl:hasBroadSynonym "vestibular component" ; oboInOwl:hasDbXref "BTO:0001856", "CALOHA:TS-0479", "EHDAA2:0000832", "EHDAA:4706", "EMAPA:17286", "EMAPA:17815", "FMA:61255", "MA:0000245", "MESH:D014722", "NCIT:C33871", "SCTID:181188003", "UMLS:C0042606", "Wikipedia:Inner_ear", "XAO:0004145" ; oboInOwl:hasExactSynonym "inner ear vestibular component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labyrinthus vestibularis", "vestibular apparatus" ; oboInOwl:id "UBERON:0001862" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vestibular labyrinth" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001849 ] . obo:UBERON_0001866 obo:IAO_0000115 "Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP]." ; obo:UBPROP_0000008 "The composition of sebum varies across species. In humans, the lipid content is as follows: 25% wax monoesters, 41% triglycerides, 16% free fatty acids, 12% squalene; Sapienic acid is a sebum fatty acid that is unique to humans." ; obo:UBPROP_0000009 "waterproofs skin" ; oboInOwl:hasDbXref "BTO:0001981", "ENVO:02000037", "FMA:61304", "GAID:1168", "MA:0002538", "MESH:D012629", "NCIT:C13276", "UMLS:C0036511", "Wikipedia:Sebaceous_glands#Sebum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001866" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "sebum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_15440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:UBERON_0001867 obo:IAO_0000115 "A cartilage that is part of a external ear [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37706", "FMA:61339", "GAID:103", "MA:0001886", "MESH:D004425", "NCIT:C49225", "UMLS:C0013445" ; oboInOwl:hasExactSynonym "external ear cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001867" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cartilage of external ear" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_0001868 obo:IAO_0000115 "A zone of skin that is part of a chest [Automatically generated definition]." ; obo:IAO_0000116 "check FMA:61415" ; oboInOwl:hasDbXref "EMAPA:37279", "FMA:61416", "MA:0000553", "SCTID:181496004" ; oboInOwl:hasExactSynonym "anterior thoracic region zone of skin", "anterolateral part of thorax zone of skin", "chest skin", "chest zone of skin", "front of thorax zone of skin", "zone of skin of anterior chest", "zone of skin of anterior part of thorax", "zone of skin of anterior thoracic region", "zone of skin of anterolateral part of thorax", "zone of skin of chest", "zone of skin of front of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "zone of skin of pectoral part of chest" ; oboInOwl:id "UBERON:0001868" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of chest" ; rdfs:subClassOf obo:UBERON_0001418, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0001869 obo:IAO_0000115 "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]." ; obo:UBPROP_0000001 "Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO]" ; obo:UBPROP_0000003 "The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010480", "BAMS:HEM", "BIRNLEX:1042", "BTO:0000231", "CALOHA:TS-2007", "DMBA:15739", "EFO:0002521", "EMAPA:16653", "FMA:61817", "MA:0000133", "MBA:403", "NCIT:C12351", "SCTID:278251007", "UMLS:C0228174", "UMLS:C0242202", "VHOG:0001639", "Wikipedia:Cerebral_hemisphere", "galen:CerebralHemisphere", "neuronames:241" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebrum", "hemisphere", "hemispheric regions", "hemispherium cerebri", "medial amygdalar nucleus", "nucleus amygdaloideus medialis", "nucleus medialis amygdalae" ; oboInOwl:id "UBERON:0001869" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cerebral hemisphere" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000955 ], _:genid120743 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png"^^xsd:anyURI . obo:UBERON_0001870 obo:IAO_0000115 "Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified]." ; obo:UBPROP_0000001 "Anterior portion of the frontal cortex, lying anterior to the central sulcus. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally." ; oboInOwl:hasDbXref "BTO:0000484", "DHBA:10161", "DMBA:16002", "EMAPA:35357", "FMA:242199", "GAID:674", "MA:0000905", "NLXANAT:20090601", "Wikipedia:Frontal_lobe" ; oboInOwl:hasExactSynonym "cortex of frontal lobe", "frontal lobe cortex", "gray matter of frontal lobe", "grey matter of frontal lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "frontal neocortex" ; oboInOwl:id "UBERON:0001870" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "frontal cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016525 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray729.png"^^xsd:anyURI . obo:UBERON_0001871 obo:IAO_0000115 "Lower lateral part of the cerebral hemisphere. (MSH)." ; oboInOwl:hasDbXref "BAMS:TL", "BAMS:Temporal_lobe", "BIRNLEX:1160", "BTO:0001355", "CALOHA:TS-1020", "DHBA:12139", "EFO:0000917", "EMAPA:18797", "EV:0100169", "FMA:61825", "GAID:635", "HBA:4132", "MAT:0000508", "MESH:D013702", "NCIT:C12353", "SCTID:180921000", "UMLS:C0039485", "UMLS:C1268978", "Wikipedia:Temporal_lobe", "neuronames:125" ; oboInOwl:hasExactSynonym "lobus temporalis" ; oboInOwl:hasNarrowSynonym "temporal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001871" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Boundary notes: It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. [Wikipedia:Temporal_lobe]" ; rdfs:label "temporal lobe" ; rdfs:subClassOf obo:UBERON_0016526, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001893 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Gray730.png"^^xsd:anyURI . obo:UBERON_0001872 obo:IAO_0000115 "Upper central part of the cerebral hemisphere. (MSH)." ; oboInOwl:hasBroadSynonym "parietal region" ; oboInOwl:hasDbXref "BAMS:Parietal_lobe", "BIRNLEX:1148", "BTO:0001001", "CALOHA:TS-0747", "DHBA:12131", "EFO:0000914", "EV:0100168", "FMA:61826", "GAID:680", "HBA:4084", "MAT:0000506", "MESH:D010296", "NCIT:C12354", "SCTID:180922007", "UMLS:C0030560", "Wikipedia:Parietal_lobe", "neuronames:95" ; oboInOwl:hasExactSynonym "regio parietalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobus parietalis" ; oboInOwl:id "UBERON:0001872" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "parietal lobe" ; rdfs:subClassOf obo:UBERON_0016526, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001871 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001893 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray726_parietal_lobe.png"^^xsd:anyURI . obo:UBERON_0001873 obo:IAO_0000115 "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species." ; obo:UBPROP_0000001 "Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833]." ; oboInOwl:hasAlternativeId "UBERON:0010122" ; oboInOwl:hasDbXref "BAMS:CA", "BAMS:Cd", "BIRNLEX:1373", "BM:Tel-CA", "BTO:0000211", "CALOHA:TS-0121", "DHBA:10334", "DMBA:15855", "EFO:0000907", "EHDAA2:0004461", "EMAPA:18207", "EV:0100185", "FMA:61833", "GAID:670", "HBA:4278", "MA:0000894", "MAT:0000513", "MESH:D002421", "NCIT:C12451", "PBA:10082", "SCTID:279297002", "UMLS:C0007461", "Wikipedia:Caudate_nucleus", "neuronames:226" ; oboInOwl:hasExactSynonym "caudatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Ammon horn fields", "caudatum", "nucleus caudatus" ; oboInOwl:id "UBERON:0001873" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "caudate nucleus" ; rdfs:subClassOf obo:UBERON_0000125, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005383 ], _:genid120783, _:genid120785, _:genid120787, _:genid120789 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg"^^xsd:anyURI . obo:UBERON_0001874 obo:IAO_0000115 "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." ; obo:IAO_0000116 "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)" ; obo:UBPROP_0000001 "Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]." ; obo:UBPROP_0000003 "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:PU", "BAMS:Pu", "BIRNLEX:809", "BM:Tel-Pu", "CALOHA:TS-2041", "DHBA:10338", "DMBA:15857", "EMAPA:35719", "EV:0100187", "FMA:61834", "GAID:671", "HBA:4287", "MA:0000895", "MESH:D011699", "NCIT:C12452", "PBA:10086", "SCTID:281512002", "UMLS:C0034169", "VHOG:0001456", "Wikipedia:Putamen", "neuronames:230" ; oboInOwl:hasExactSynonym "nucleus putamen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001874" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "putamen" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002435 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005383 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005383 ], _:genid120800 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg"^^xsd:anyURI . obo:UBERON_0001875 obo:IAO_0000115 "Subcortical nucleus, functionally part of the basal ganglia, which consists of two segments the external (or lateral) and internal (or medial) separated by the medial medullary lamina in primates. In rodents, The globus pallidus lateral is separated from the medial segment by the fibers of the internal capsule/cerebral peduncle." ; obo:UBPROP_0000001 "Nucleus of brain which is located medially to the putamen and laterally to the internal capsule[FMA][FMA:61835]." ; obo:UBPROP_0000007 "pallidal" ; oboInOwl:hasDbXref "BAMS:GP", "BIRNLEX:1234", "BTO:0002246", "CALOHA:TS-2013", "DHBA:10342", "EFO:0000905", "EMAPA:35380", "EV:0100188", "FMA:61835", "GAID:668", "HBA:4293", "MA:0000890", "MAT:0000510", "MESH:D005917", "NCIT:C12449", "PBA:10097", "SCTID:362361005", "UMLS:C0017651", "Wikipedia:Globus_pallidus", "neuronames:231" ; oboInOwl:hasExactSynonym "pale body", "paleostriatum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "globus pallidus (Burdach)", "nucleus pallidus", "pallidium", "pallidum" ; oboInOwl:id "UBERON:0001875" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "BTO and MA are inconsistent w.r.t striatum and pallidum being non-overlapping as in ABA. Note that we have pallidum as part_of basal gangion, so we can make the direct link to basal ganglion. ISBN:1588900649 says: ... a derivative of the diencephalon, seperates as a result of growing fibers of theinternal capsule and is finally displaced into telencephalon. only a small medial remnannt remains, the entopeduncular nucleus. The globus pallidus should be regarded as part of the subthalamus" ; rdfs:label "globus pallidus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0010011 ], _:genid120811, _:genid120813, _:genid120815, _:genid120817 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif"^^xsd:anyURI . obo:UBERON_0001884 obo:IAO_0000115 "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." ; obo:UBPROP_0000001 "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG]" ; oboInOwl:hasDbXref "BAMS:phn", "BTO:0001063", "EHDAA:4677", "EMAPA:17813", "FMA:6191", "GAID:848", "MA:0001170", "MESH:D010791", "NCIT:C52813", "SCTID:280344009", "UMLS:C0031774", "VHOG:0000728", "Wikipedia:Phrenic_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diaphragmatic nerve", "nervus phrenicus", "phrenic" ; oboInOwl:id "UBERON:0001884" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "phrenic nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000962 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png"^^xsd:anyURI . obo:UBERON_0001886 obo:IAO_0000115 "A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces." ; obo:IAO_0000116 "TODO - check relationship to ventricle. Check subclass - ZFA says vasculature. Note that FMA:61934 (choroid plexus of cerebral hemisphere) has exact synonym 'choroid plexus' but it is not clear that this belongs here, as the fourth ventricle is not in the cerebral hemisphere" ; obo:UBPROP_0000001 "A tuft of capillaries that project into the ventricles of the brain and secretes cerebral spinal fluid. The choroid plexus is covered by a cuboidal epithelium which maintains the integrity of the blood-brain barrier.[TAO]", "Fringe of the tela choroidea of the brain ventricles[MP]" ; obo:UBPROP_0000007 "choroidal" ; oboInOwl:hasBroadSynonym "CP" ; oboInOwl:hasDbXref "BAMS:CHP", "BAMS:GHP", "BAMS:chp", "BAMS:chpl", "BTO:0000258", "CALOHA:TS-0145", "EFO:0001915", "EMAPA:32741", "FMA:61934", "GAID:607", "MA:0000823", "MBA:108", "MESH:D002831", "NCIT:C12694", "SCTID:264450003", "TAO:0001443", "UMLS:C0008524", "VHOG:0001377", "Wikipedia:Choroid_plexus", "ZFA:0001443", "neuronames:1377" ; oboInOwl:hasExactSynonym "chorioid plexus", "plexus choroideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "choroid plexus of cerebral hemisphere", "plexus choroideus", "ventricular choroid plexus" ; oboInOwl:id "UBERON:0001886" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "choroid plexus" ; rdfs:subClassOf obo:UBERON_0005629, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004086 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005283 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003947 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray708.svg"^^xsd:anyURI . obo:UBERON_0001887 obo:IAO_0000115 "White matter regional part of brain which is flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem and spinal cord. It consists of three distinct parts: an anterior limb, posterior limb, and genu. (Adapted from MSH by Maryann Martone)." ; oboInOwl:hasBroadSynonym "internal capsule" ; oboInOwl:hasDbXref "BAMS:ic", "BAMS:int", "BIRNLEX:1659", "BM:IC", "DHBA:10581", "DMBA:17770", "EMAPA:18206", "EMAPA:35437", "FMA:61950", "GAID:685", "HBA:9263", "MA:0002748", "MBA:6", "MESH:D020772", "NCIT:C13082", "PBA:10102", "SCTID:85637007", "UMLS:C0152341", "Wikipedia:Internal_capsule" ; oboInOwl:hasExactSynonym "brain internal capsule", "internal capsule radiations" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "capsula interna" ; oboInOwl:id "UBERON:0001887" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "internal capsule of telencephalon" ; rdfs:subClassOf obo:UBERON_0002316, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg"^^xsd:anyURI . obo:UBERON_0001889 oboInOwl:hasDbXref "EHDAA2:0001463", "EMAPA:37718", "FMA:6198", "MA:0001177" ; oboInOwl:hasExactSynonym "phrenic nerve trunk", "phrenic neural trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001889" ; a owl:Class ; rdfs:label "trunk of phrenic nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001884 ] ) ] . obo:UBERON_0001890 obo:IAO_0000115 "The most anterior region of the brain including both the telencephalon and diencephalon." ; obo:UBPROP_0000001 "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]", "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" ; obo:UBPROP_0000003 "In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG]" ; obo:UBPROP_0000007 "prosencephalic" ; oboInOwl:hasBroadSynonym "FB" ; oboInOwl:hasDbXref "AAO:0010147", "BAMS:FB", "BAMS:Forebrain", "BIRNLEX:1509", "BTO:0000478", "CALOHA:TS-0380", "DHBA:10156", "DMBA:15566", "EFO:0000909", "EHDAA2:0000556", "EHDAA:3470", "EMAPA:16895", "FMA:61992", "MA:0000170", "MAT:0000105", "MESH:D016548", "MIAA:0000105", "NCIT:C40185", "SCTID:362291003", "TAO:0000109", "UMLS:C0085140", "VHOG:0000383", "Wikipedia:Forebrain", "XAO:0000011", "ZFA:0000109", "neuronames:27" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prosencephalon" ; oboInOwl:id "UBERON:0001890" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "forebrain" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003080 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ], _:genid120868 ; owl:disjointWith obo:UBERON_0002298 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg"^^xsd:anyURI . obo:UBERON_0001891 obo:IAO_0000115 "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." ; obo:IAO_0000116 "developmental relationships need revised" ; obo:RO_0002171 obo:UBERON_0001894, obo:UBERON_0002028 ; obo:UBPROP_0000001 "Middle part of the brain composed of the optic tectum and penducular region.[AAO]", "The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" ; obo:UBPROP_0000007 "mesencephalic" ; obo:UBPROP_0000012 "part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships" ; oboInOwl:hasBroadSynonym "MB" ; oboInOwl:hasDbXref "AAO:0010149", "BAMS:MES", "BIRNLEX:1667", "BM:MB", "BTO:0000138", "CALOHA:TS-0630", "DHBA:10648", "DMBA:16649", "EFO:0000919", "EHDAA2:0001162", "EHDAA:3694", "EMAPA:16974", "EV:0100242", "FMA:61993", "HBA:9001", "MA:0000207", "MAT:0000106", "MBA:313", "MESH:D008636", "MIAA:0000106", "NCIT:C12510", "RETIRED_EHDAA2:0001104", "SCTID:279099009", "TAO:0000128", "UMLS:C0025462", "VHOG:0000069", "Wikipedia:Midbrain", "XAO:0000014", "ZFA:0000128", "neuronames:462" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalon" ; oboInOwl:id "UBERON:0001891" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "midbrain" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ], _:genid120879, _:genid120882 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG"^^xsd:anyURI . obo:UBERON_0001892 obo:IAO_0000115 "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." ; obo:UBPROP_0000001 "A segment of the developing hindbrain. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG]" ; obo:UBPROP_0000008 "In human embryonic development, the rhombomeres are present by day 29" ; obo:UBPROP_0000012 "DHBA divides this into A(1-3),B(4),C(5-7) and D(8)" ; oboInOwl:hasBroadSynonym "hindbrain segment", "segment of hindbrain" ; oboInOwl:hasDbXref "DHBA:12664", "EFO:0003617", "EMAPA:16148", "FMA:295666", "MAT:0000272", "MIAA:0000272", "RETIRED_EHDAA2:0000669", "TAO:0001064", "VHOG:0000672", "Wikipedia:Rhombomere", "XAO:0004079", "ZFA:0001064" ; oboInOwl:hasExactSynonym "hindbrain neuromere", "hindbrain neuromeres", "rhombomere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future rhombencephalon", "rhombomeres" ; oboInOwl:id "UBERON:0001892" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "rhombomere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007277 ] ) ] . obo:UBERON_0001893 obo:IAO_0000115 "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." ; obo:RO_0002171 obo:UBERON_0002037 ; obo:UBPROP_0000001 "Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000].", "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO]", "The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO]" ; obo:UBPROP_0000003 "From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG]" ; obo:UBPROP_0000007 "cerebral", "telencephalic", "telenencephalic" ; obo:UBPROP_0000008 "In mammals the cortex covers almost the whole of the cerebral hemispheres.", "In ray-finned fishes and most pronounced in teleosts the roof plate of the embryonic telencephalon extends laterally with the effect that the paired alar plates forming the hemispheric walls roll out lateroventrally in a process called eversion. This is unlike the development in other vertebrate groups. [ZFA:0000079, ISBN:3764351209]", "In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles.", "In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum.", "In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb.", "The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure.", "dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight." ; oboInOwl:hasBroadSynonym "supratentorial region" ; oboInOwl:hasDbXref "AAO:0010479", "BAMS:CB", "BAMS:CH", "BAMS:IV", "BAMS:Tel", "BIRNLEX:1115", "BM:Tel", "BTO:0000239", "CALOHA:TS-1018", "DHBA:10158", "EFO:0000912", "EHDAA2:0001982", "EMAPA:16910", "EV:0100165", "FMA:62000", "GAID:621", "HBA:4007", "MA:0000183", "MAT:0000421", "MBA:567", "MESH:D013687", "MIAA:0000421", "PBA:128011350", "SCTID:263353005", "TAO:0000079", "UMLS:C0039452", "VHOG:0000283", "Wikipedia:Telencephalon", "XAO:0000012", "ZFA:0000079", "neuronames:31" ; oboInOwl:hasExactSynonym "cerebrum", "endbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001893" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "telencephalon" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ], _:genid120908 . obo:UBERON_0001894 obo:IAO_0000115 "The division of the forebrain that develops from the foremost primary cerebral vesicle." ; obo:RO_0002171 obo:UBERON_0001891, obo:UBERON_0002028 ; obo:UBPROP_0000001 "The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]", "Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO]" ; obo:UBPROP_0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" ; obo:UBPROP_0000007 "diencephalic" ; obo:UBPROP_0000012 "in ABA, this is part of the brain stem" ; oboInOwl:hasBroadSynonym "DiE" ; oboInOwl:hasDbXref "AAO:0010481", "BAMS:DI", "BAMS:Di", "BAMS:DiE", "BAMS:IB", "BAMS:Zh.", "BIRNLEX:1503", "BM:Die", "BTO:0000342", "CALOHA:TS-0199", "DHBA:10389", "DMBA:16308", "EFO:0000911", "EHDAA2:0000385", "EHDAA:1969", "EHDAA:2645", "EHDAA:3472", "EMAPA:16896", "EV:0100194", "FMA:62001", "GAID:618", "HBA:4391", "MA:0000171", "MAT:0000420", "MBA:1129", "MESH:D004027", "MIAA:0000420", "NCIT:C12456", "PBA:128013010", "SCTID:279328001", "TAO:0000101", "UMLS:C0012144", "VHOG:0000318", "Wikipedia:Diencephalon", "XAO:0000013", "ZFA:0000101", "neuronames:288" ; oboInOwl:hasExactSynonym "between brain", "interbrain", "mature diencephalon", "thalamencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "betweenbrain", "diencephalon" ; oboInOwl:id "UBERON:0001894" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "diencephalon" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001890 ], _:genid120929, _:genid120932 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg"^^xsd:anyURI . obo:UBERON_0001895 obo:IAO_0000115 "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." ; obo:UBPROP_0000001 "Anterior part of the hindbrain ventral to the cerebellum[BIRNLEX:965].", "The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG]" ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasBroadSynonym "epencephalon" ; oboInOwl:hasDbXref "BAMS:Met", "BIRNLEX:965", "BTO:0000673", "CALOHA:TS-2029", "DHBA:10655", "EHDAA2:0001149", "EHDAA:5498", "EMAPA:17071", "FMA:62003", "GAID:594", "HBA:4833", "MA:0000197", "MESH:D020540", "NCIT:C32741", "UMLS:C0376353", "UMLS:C1516904", "VHOG:0000741", "Wikipedia:Metencephalon", "neuronames:543" ; oboInOwl:hasExactSynonym "epencephalon-2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001895" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]." ; rdfs:label "metencephalon" ; rdfs:subClassOf obo:UBERON_0000063, _:genid120277, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002028 ], _:genid120951 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg"^^xsd:anyURI . obo:UBERON_0001896 obo:IAO_0000115 "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." ; obo:UBPROP_0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]", "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "bulb", "medulla" ; oboInOwl:hasDbXref "AAO:0010486", "BAMS:MY", "BAMS:Md", "BIRNLEX:957", "BM:Me", "BTO:0000041", "CALOHA:TS-0607", "DMBA:17352", "EFO:0000924", "EHDAA2:0001088", "EHDAA:7588", "EMAPA:17550", "EV:0100275", "FMA:62004", "GAID:590", "MA:0000206", "MAT:0000111", "MAT:0000367", "MBA:354", "MESH:D008526", "MIAA:0000111", "NCIT:C12442", "SCTID:279104005", "TAO:0000545", "UMLS:C0025148", "UMLS:C1269575", "VHOG:0000181", "Wikipedia:Bone_marrow_of_ovary_oblongata", "XAO:0003100", "ZFA:0000545", "neuronames:698" ; oboInOwl:hasExactSynonym "bulbus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medulla oblonzata", "metepencephalon" ; oboInOwl:id "UBERON:0001896" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "medulla oblongata" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005290 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0043576 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0044058 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg"^^xsd:anyURI . obo:UBERON_0001897 obo:IAO_0000115 "Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87)." ; obo:RO_0002171 obo:UBERON_0001898 ; obo:UBPROP_0000001 "One of a pair of large oval nervous structures made of gray matter and forming most of the lateral walls of the third ventricle of the brain and part of the diencephalon. [TFD][VHOG]", "Part of the diencephalon consisting of a mass of connecting fibers which relay sensory information to the cerebral cortex.[AAO]" ; obo:UBPROP_0000003 "(...) the brain regions of tetrapods, the structures they contain, and their basic organizational features are the same as in fishes.[well established][VHOG]" ; obo:UBPROP_0000007 "thalamic" ; oboInOwl:hasBroadSynonym "Th", "thalamus" ; oboInOwl:hasDbXref "AAO:0010483", "BAMS:TH", "BAMS:Th", "BIRNLEX:954", "BTO:0001365", "CALOHA:TS-1031", "DHBA:10390", "DMBA:16376", "EFO:0000910", "EMAPA:17540", "EV:0100195", "GAID:656", "HBA:4392", "MA:0000179", "MAT:0000109", "MBA:549", "MIAA:0000109", "NCIT:C12459", "PBA:128013014", "SCTID:244433007", "TAO:0001215", "UMLS:C0039729", "VHOG:0000657", "Wikipedia:Thalamus", "ZFA:0001215", "galen:Thalamus", "neuronames:300" ; oboInOwl:hasExactSynonym "wider thalamus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thalamencephalon", "thalami", "thalamus opticus" ; oboInOwl:id "UBERON:0001897" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal plus ventral thalamus" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010225 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001894 ], _:genid120980 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Brain_chrischan_thalamus.jpg"^^xsd:anyURI . obo:UBERON_0001898 obo:IAO_0000115 "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." ; obo:RO_0002171 obo:UBERON_0001897 ; obo:UBPROP_0000001 "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. Kimmel et al, 1995.[TAO]", "Part of the diencephalon ventral to the thalamus consisting of connecting fibers and is a center for control of the autonomous nervous system.[AAO]" ; obo:UBPROP_0000003 "For instance, the vertebrate ventral diencephalon generates the hypothalamus which functions as a major endocrine center in cooperation with the hypophysis, the anterior part of the pituitary gland, located just ventral to the hypothalamus. In the amphioxus brain, the presence of a hypothalamus-like structure has been reported associated with the ventrally located Hatschek's pit, the hypothetical hypophysial homologue. It is thus conceivable that a hypothalamus-like structure originally involved in endocrine functions may have already been present before the establishment of vertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "hypothalamic" ; obo:UBPROP_0000008 "all vertebrates contain a hypothalamus" ; oboInOwl:hasBroadSynonym "Hy" ; oboInOwl:hasDbXref "AAO:0010484", "BAMS:HY", "BAMS:Hy", "BIRNLEX:734", "BM:Die-Hy", "BTO:0000614", "CALOHA:TS-0469", "DHBA:10467", "EFO:0000107", "EHDAA2:0000802", "EHDAA:5446", "EMAPA:17536", "EV:0100225", "FMA:62008", "GAID:460", "HBA:4540", "MA:0000173", "MAT:0000112", "MBA:1097", "MESH:D007031", "MIAA:0000112", "NCIT:C12458", "SCTID:264483005", "TAO:0000032", "UMLS:C0020663", "VHOG:0000179", "Wikipedia:Hypothalamus", "XAO:0004070", "ZFA:0000032", "galen:Hypothalamus", "neuronames:292" ; oboInOwl:hasExactSynonym "preoptico-hypothalamic area", "preoptico-hypothalamic region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hypothalamus" ; oboInOwl:id "UBERON:0001898" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hypothalamus" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000349 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001894 ], _:genid120997, _:genid120999 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/LocationOfHypothalamus.jpg"^^xsd:anyURI . obo:UBERON_0001899 obo:IAO_0000115 "Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346." ; obo:RO_0002171 obo:UBERON_0001903, obo:UBERON_0002733, obo:UBERON_0002736 ; obo:UBPROP_0000001 "Dorsal segment of the diencephalon containing the habenular ganglia, a choroid plexus, and the pineal organ.[AAO]", "The roof of the diencephalon lying above the thalamus. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-11, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "The epithalamus has been historically conceived as a distinct neuroanatomical moiety within the diencephalon of all vertebrates. (...) The evolutionary origins of epithalamic structures are uncertain but asymmetry in this region is likely to have existed at the origin of the vertebrate, perhaps even the chordate, lineage.[well established][VHOG]" ; obo:UBPROP_0000007 "epithalamic" ; oboInOwl:hasBroadSynonym "ETh" ; oboInOwl:hasDbXref "AAO:0010482", "BAMS:EPI", "BAMS:ETh", "BAMS:EpT", "BAMS:Epi", "BIRNLEX:1710", "BM:Die-Epi", "BTO:0000175", "CALOHA:TS-2060", "DHBA:10451", "EFO:0000918", "EHDAA2:0000448", "EHDAA:5433", "EMAPA:17532", "EV:0100220", "FMA:62009", "GAID:455", "HBA:4520", "MA:0000172", "MAT:0000422", "MBA:958", "MESH:D019261", "MIAA:0000422", "NCIT:C12457", "PBA:128013147", "SCTID:281487003", "TAO:0000509", "UMLS:C0152361", "VHOG:0000178", "Wikipedia:Epithalamus", "ZFA:0000509", "neuronames:292" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithalamus" ; oboInOwl:id "UBERON:0001899" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "epithalamus" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001897 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001894 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Epithalamus.png"^^xsd:anyURI . obo:UBERON_0001901 obo:IAO_0000115 "The epithelial lining of the trachea which contains numerous ciliated cells." ; oboInOwl:hasAlternativeId "UBERON:0003227" ; oboInOwl:hasDbXref "BTO:0001389", "CALOHA:TS-1061", "EHDAA2:0002069", "EHDAA:5007", "EMAPA:16855", "EMAPA:18409", "FMA:62015", "MA:0001862", "NCIT:C33797", "UMLS:C1179002", "VHOG:0001045" ; oboInOwl:hasExactSynonym "epithelial tissue of trachea", "epithelial tissue of windpipe", "epithelium of windpipe", "trachea epithelial tissue", "trachea epithelium", "tracheal epithelium", "windpipe epithelial tissue", "windpipe epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001901" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of trachea" ; rdfs:subClassOf obo:UBERON_0000485, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003258 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003126 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0001902 obo:IAO_0000115 "An epithelium that is part of a small intestine [Automatically generated definition]." ; obo:UBPROP_0000001 "Intestinal epithelium which lines the lumen of the mid intestine.[TAO]" ; oboInOwl:hasDbXref "BTO:0001258", "CALOHA:TS-2104", "EMAPA:35778", "FMA:62017", "MA:0001553", "SCTID:45480009", "TAO:0005127", "ZFA:0005127" ; oboInOwl:hasExactSynonym "epithelial tissue of small bowel", "epithelial tissue of small intestine", "epithelium of small bowel", "mid intestine epithelium", "small bowel epithelial tissue", "small bowel epithelium", "small intestinal epithelium", "small intestine epithelial tissue", "small intestine epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001902" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "epithelium of small intestine" ; rdfs:subClassOf obo:UBERON_0001277, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001204 ], _:genid121044 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0001905 obo:IAO_0000115 "A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399)." ; obo:RO_0002171 obo:UBERON_0001941, obo:UBERON_0001942 ; obo:UBPROP_0000001 "A circumscribed swelling, includes the pineal primordium that appears late in the segmentation period in the dorsal midline of the diencephalon. Kimmel et al, 1995.[TAO]", "Anatomical structure which is a medial outgrowth of the thalamus on the dorsal surface of the brain. This structure is light sensitive and secretes melatonin when exposed to prolonged darkness.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of pineal complex (TAO:0001359)[TAO]" ; obo:UBPROP_0000003 "The pineal gland has evolved from a part of the epiphyseal complex of anamniotes, which includes a median light-receptive pineal eye, parietal eye, or both.[well established][VHOG]" ; obo:UBPROP_0000007 "epiphyseal", "epiphysial" ; obo:UBPROP_0000008 "lobulated in humans, homogeneous in mouse. Calcifies with age in humans." ; oboInOwl:hasBroadSynonym "Pi" ; oboInOwl:hasDbXref "AAO:0010549", "BAMS:PIN", "BAMS:Pi", "BIRNLEX:1184", "BM:P", "BTO:0001067", "CALOHA:TS-0789", "DHBA:10460", "EFO:0000865", "EHDAA2:0001466", "EHDAA:7523", "EMAPA:18778", "EV:0100131", "EV:0100221", "FMA:62033", "GAID:453", "HBA:4532", "MA:0000175", "MAT:0000448", "MBA:953", "MESH:D010870", "NCIT:C12398", "NLXANAT:1010009", "SCTID:181126002", "TAO:0000019", "UMLS:C0031939", "VHOG:0000051", "Wikipedia:Pineal_gland", "XAO:0000160", "ZFA:0000019", "galen:PinealGland", "neuronames:297" ; oboInOwl:hasExactSynonym "corpus pineale", "glandula pinealis", "pineal gland", "pineal organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "conarium", "epiphysis", "epiphysis cerebri", "frontal organ", "pineal", "pineal gland (Galen)", "stirnorgan" ; oboInOwl:id "UBERON:0001905" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pineal body" ; rdfs:subClassOf obo:UBERON_0010134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000652 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002220 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001899 ], _:genid121056, _:genid121060 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg"^^xsd:anyURI . obo:UBERON_0001908 obo:IAO_0000115 "Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF]." ; obo:IAO_0000116 "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" ; oboInOwl:hasDbXref "BAMS:opt", "BIRNLEX:1684", "BM:Tel-OT", "DHBA:10589", "DMBA:17785", "EMAPA:16678", "EMAPA:35617", "FMA:62046", "GAID:735", "HBA:9309", "MA:0001099", "MBA:125", "MESH:D014795", "NCIT:C33218", "SCTID:280952003", "TAO:0000252", "UMLS:C0152405", "VHOG:0001164", "Wikipedia:Optic_tract", "XAO:0004101", "ZFA:0000252", "neuronames:460" ; oboInOwl:hasExactSynonym "optic lemniscus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "optic tracts", "tractus optici", "tractus opticus", "visual pathway" ; oboInOwl:id "UBERON:0001908" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "optic tract" ; rdfs:subClassOf obo:UBERON_0001018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002104 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003931 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003544 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000941 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000959 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png"^^xsd:anyURI . obo:UBERON_0001911 obo:IAO_0000115 "A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males." ; obo:IAO_0000116 "Originally this was classified as a female reproductive structure, as it was in the MP in 2011" ; obo:UBPROP_0000001 "Any of the milk-producing apocrine glands typically occurring in pairs in female mammals and consisting of lobes containing clusters of alveoli with a system of ducts to convey the milk to an external nipple or teat. [TFD][VHOG]" ; obo:UBPROP_0000003 "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" ; obo:UBPROP_0000007 "mammary" ; obo:UBPROP_0000008 "A mouse mammary gland contains a single duct or sinus, forming 5-10 secondary ducts", "The male Dayak fruit bat has lactating mammary glands", "The mammary glands of humans are in the thoracid/breast region. In other mammals they may be located elsewhere on the mammary ridges." ; obo:UBPROP_0000012 "The BTO class represents the combination of nipple plus lobe", "The FMA class represents an individule lobe. The nipple is not a part", "The MA class represents a composite structure, including the nipple, fat, connective tissue, smooth muscle as parts" ; oboInOwl:hasDbXref "BTO:0000817", "CALOHA:TS-0595", "EFO:0000854", "EMAPA:17759", "EV:0100125", "FMA:286452", "MA:0000145", "MAT:0000073", "MESH:D008321", "MIAA:0000073", "NCIT:C12367", "SCTID:361720005", "UMLS:C0929301", "VHOG:0000398", "Wikipedia:Mammary_gland" ; oboInOwl:hasExactSynonym "glandula mammaria", "lactiferous gland" ; oboInOwl:hasNarrowSynonym "lobe of breast", "milk patch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Brustdruese", "dug", "glandula mammaria", "lobe of mammary gland", "mamma", "mammae" ; oboInOwl:id "UBERON:0001911" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mammary gland" ; rdfs:subClassOf obo:UBERON_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005333 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001913 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007595 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg"^^xsd:anyURI . obo:UBERON_0001912 obo:IAO_0000115 "Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA]." ; obo:IAO_0000116 "TODO - ensure correct terminology for lobes/lobules. In mouse there are no distinct lobes (ISBN:0123813611), here lobule appears to be synonymous with acinus" ; oboInOwl:hasDbXref "EMAPA:36634", "FMA:62090", "MA:0000793" ; oboInOwl:hasExactSynonym "acinus of mammary gland", "lactiferous acinus", "lactiferous gland lobule", "lactiferous lobule", "lobule of lactiferous gland", "lobule of mammary gland", "mammary acinus", "mammary gland lobule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001912" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lobule of mammary gland" ; rdfs:subClassOf obo:UBERON_0009911, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ], _:genid120439 . obo:UBERON_0001913 obo:IAO_0000115 "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." ; obo:IAO_0000116 "to axiomatize the different forms of mammary gland secretion an ontology of the phases of pregnancy/lactation is required. Using the existing GO def of lactation is circular." ; obo:UBPROP_0000003 "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" ; obo:UBPROP_0000012 "ncit:Milk refers specifically to cow milk" ; oboInOwl:hasDbXref "BTO:0000868", "CALOHA:TS-0636", "EMAPA:36540", "ENVO:02000031", "EV:0100126", "FMA:62100", "GAID:1230", "MA:0002552", "MAT:0000056", "MESH:D008892", "MIAA:0000056", "NCIT:C13401", "UMLS:C1511310", "VHOG:0001263", "Wikipedia:Breast_milk", "galen:Milk" ; oboInOwl:hasExactSynonym "mammary gland milk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001913" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "milk" ; rdfs:subClassOf obo:UBERON_0000456, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_18059 ], _:genid120451, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0007595 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001911 ] . obo:UBERON_0001915 obo:IAO_0000115 "An endothelium that is part of a capillary [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004954", "CALOHA:TS-0112", "EMAPA:36292", "FMA:62114", "MA:0000711", "NCIT:C49215", "UMLS:C0006904" ; oboInOwl:hasExactSynonym "blood capillary endothelium", "capillary endothelium", "capillary vessel endothelium", "endothelium of blood capillary", "endothelium of capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001915" ; a owl:Class ; rdfs:label "endothelium of capillary" ; rdfs:subClassOf obo:UBERON_0001986, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001982 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001982 ] ) ] . obo:UBERON_0001916 obo:IAO_0000115 "An endothelium that is part of an arteriole [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36286", "FMA:62115", "MA:0000705", "NCIT:C49192", "UMLS:C1179024" ; oboInOwl:hasExactSynonym "arteriole endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001916" ; a owl:Class ; rdfs:label "endothelium of arteriole" ; rdfs:subClassOf obo:UBERON_0001986, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ) ] . obo:UBERON_0001917 obo:IAO_0000115 "An endothelium that is part of an artery [Automatically generated definition]." ; obo:UBPROP_0000001 "The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO]" ; obo:UBPROP_0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011013", "BTO:0004757", "EMAPA:35148", "FMA:62116", "MA:0000707", "NCIT:C49194", "UMLS:C1179025", "VHOG:0001215", "XAO:0000357" ; oboInOwl:hasExactSynonym "arterial endothelium", "artery endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001917" ; a owl:Class ; rdfs:label "endothelium of artery" ; rdfs:subClassOf obo:UBERON_0003915 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0001918 obo:IAO_0000115 "An endothelium that is part of a venule [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36290", "FMA:62117", "MA:0000716", "NCIT:C49319", "UMLS:C1179026" ; oboInOwl:hasExactSynonym "venule endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001918" ; a owl:Class ; rdfs:label "endothelium of venule" ; rdfs:subClassOf obo:UBERON_0001986, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001979 ] ) ] . obo:UBERON_0001919 obo:IAO_0000115 "An endothelium that is part of a vein [Automatically generated definition]." ; obo:UBPROP_0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011110", "BTO:0004756", "EMAPA:36288", "FMA:62118", "MA:0000712", "NCIT:C49317", "UMLS:C1179027", "VHOG:0001216", "XAO:0000358" ; oboInOwl:hasExactSynonym "vein endothelium", "venous endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "veinous endothelium" ; oboInOwl:id "UBERON:0001919" ; a owl:Class ; rdfs:label "endothelium of vein" ; rdfs:subClassOf obo:UBERON_0001986 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0001943 obo:IAO_0000115 "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." ; obo:UBPROP_0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "MTg", "tegmentum" ; oboInOwl:hasDbXref "BAMS:MTg", "BIRNLEX:1200", "BTO:0003388", "DHBA:12195", "EFO:0000921", "EHDAA2:0004475", "EMAPA:18215", "FMA:62393", "HBA:9002", "MA:0000212", "MAT:0000452", "SCTID:362392007", "TAO:0000160", "UMLS:C0039441", "VHOG:0001367", "Wikipedia:Midbrain_tegmentum", "XAO:0004271", "ZFA:0000160", "neuronames:491" ; oboInOwl:hasExactSynonym "tegmentum mesencephali", "tegmentum of midbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalic tegmentum", "tegmentum mesencephalicum" ; oboInOwl:id "UBERON:0001943" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum" ; rdfs:label "midbrain tegmentum" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ], _:genid121181 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png"^^xsd:anyURI . obo:UBERON_0001948 obo:IAO_0000115 "A multi-tissue structure that is part of a spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1496", "NCIT:C33969", "SCTID:244437008", "UMLS:C1268166" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spinal cord part" ; oboInOwl:id "UBERON:0001948" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "regional part of spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 _:genid120514 ) ] . obo:UBERON_0001949 obo:IAO_0000115 "A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO]." ; obo:UBPROP_0000008 "In humans: 15% orthokeratinized, 75% parakeratinized, 10% non-keratinized; diurnal; decreased keratinization with age. Note that in FMA this is classified as keratinized squamous - this perhaps refers to the epithelium of the attached or free gingiva" ; oboInOwl:hasDbXref "BTO:0004998", "FMA:62423", "MA:0001576", "NCIT:C49239", "UMLS:C1179154" ; oboInOwl:hasExactSynonym "epithelial tissue of gingiva", "epithelium of gingiva", "gingiva epithelial tissue", "gingiva epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001949" ; a owl:Class ; rdfs:label "gingival epithelium" ; rdfs:subClassOf obo:UBERON_0006915 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] . obo:UBERON_0001950 obo:IAO_0000115 "An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN)." ; obo:RO_0002171 obo:UBERON_0002264 ; obo:UBPROP_0000003 "The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils" ; oboInOwl:hasDbXref "BAMS:ISO", "BAMS:Iso-cortex", "BAMS:NCX", "BIRNLEX:2547", "BTO:0000920", "DHBA:10160", "EHDAA2:0004662", "EMAPA:32842", "EMAPA:35589", "FMA:62429", "GAID:677", "MA:0002754", "MBA:315", "MESH:D019579", "PBA:294021746", "UMLS:C0175173", "Wikipedia:Neocortex", "neuronames:757" ; oboInOwl:hasExactSynonym "cerebral neocortex", "homogenetic cortex", "homotypical cortex", "isocortex (sensu lato)", "neocortex (isocortex)", "neopallial cortex", "neopallium" ; oboInOwl:hasNarrowSynonym "isocortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "iso-cortex", "nonolfactory cortex", "nucleus hypoglossalis" ; oboInOwl:id "UBERON:0001950" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "neocortex" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000956 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Neocortex.jpg"^^xsd:anyURI . obo:UBERON_0001951 obo:IAO_0000115 "An epithelium that is part of a nasopharynx [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003237" ; oboInOwl:hasDbXref "BTO:0004480", "CALOHA:TS-0662", "EHDAA2:0001241", "EHDAA:7090", "EMAPA:17672", "FMA:62452", "MA:0001865", "NCIT:C49263", "UMLS:C1179157", "VHOG:0001038" ; oboInOwl:hasExactSynonym "epithelial tissue of nasal part of pharynx", "epithelial tissue of nasopharynx", "epithelial tissue of rhinopharynx", "epithelium of nasal part of pharynx", "epithelium of rhinopharynx", "nasal part of pharynx epithelial tissue", "nasal part of pharynx epithelium", "nasopharynx epithelial tissue", "nasopharynx epithelium", "rhinopharynx epithelial tissue", "rhinopharynx epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasopharyngeal epithelium" ; oboInOwl:id "UBERON:0001951" ; a owl:Class ; rdfs:label "epithelium of nasopharynx" ; rdfs:subClassOf obo:UBERON_0000485, _:genid121226 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0001954 obo:IAO_0000115 "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." ; obo:RO_0002171 obo:UBERON_0001885, obo:UBERON_0002601 ; obo:UBPROP_0000007 "hippocampal" ; obo:UBPROP_0000012 "Non-mammalian species do not have a brain structure that looks like the mammalian hippocampus, but they have one that is considered homologous to it. The hippocampus, as pointed out above, is essentially the medial edge of the cortex. Only mammals have a fully developed cortex, but the structure it evolved from, called the pallium, is present in all vertebrates, even the most primitive ones such as the lamprey or hagfish. The pallium is usually divided into three zones: medial, lateral, and dorsal. The medial pallium forms the precursor of the hippocampus. It does not resemble the hippocampus visually, because the layers are not warped into an S shape or enwrapped by the dentate gyrus, but the homology is indicated by strong chemical and functional affinities. There is now evidence that these hippocampal-like structures are involved in spatial cognition in birds, reptiles, and fish. In birds, the correspondence is sufficiently well established that most anatomists refer to the medial pallial zone as the 'avian hippocampus'. The story for fish is more complex. In teleost fish (which make up the great majority of existing species), the forebrain is distorted in comparison to other types of vertebrates: most neuroanatomists believe that the teleost forebrain is essentially everted, like a sock turned inside-out, so that structures that lie in the interior, next to the ventricles, for most vertebrates, are found on the outside in teleost fish, and vice versa. One of the consequences of this is that the medial pallium ('hippocampal' zone) of a typical vertebrate is thought to correspond to the lateral pallium of a typical fish. Several types of fish (particularly goldfish) have been shown experimentally to have strong spatial memory abilities, even forming 'cognitive maps' of the areas they inhabit.[WP]" ; oboInOwl:hasAlternativeId "UBERON:0003940", "UBERON:0004165" ; oboInOwl:hasDbXref "BAMS:CA", "BIRNLEX:721", "BM:Tel-CAM", "BTO:0003705", "CALOHA:TS-0460", "DHBA:10296", "DMBA:16124", "EFO:0000530", "EHDAA2:0004443", "EMAPA:32772", "EMAPA:32845", "EV:0100180", "FMA:62493", "GAID:623", "MA:0000191", "MAT:0000114", "MBA:375", "MESH:D006624", "MIAA:0000114", "NCIT:C12444", "NCIT:C32374", "PBA:128012244", "SCTID:361561007", "UMLS:C0019564", "VHOG:0001177", "Wikipedia:Hippocampus", "http://scalablebrainatlas.incf.org/services/thumbnail.php?template=ABA07&size=L&dim=2d3d&format=png®ion=CA", "neuronames:3157" ; oboInOwl:hasExactSynonym "Ammon's horn", "ammon gyrus", "ammon horn", "hippocampus major", "hippocampus proper", "hippocampus proprius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Ammon horn fields", "Ammons horn", "cornu ammonis", "hippocampus" ; oboInOwl:id "UBERON:0001954" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "Ammon's horn" ; rdfs:subClassOf obo:UBERON_0002616, _:genid121241, _:genid121243, _:genid121245, _:genid121247 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray739-emphasizing-hippocampus.png"^^xsd:anyURI . obo:UBERON_0001956 obo:IAO_0000115 "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." ; oboInOwl:hasDbXref "EMAPA:35192", "FMA:62649", "MA:0001835", "NCIT:C49209", "SCTID:278980009", "UMLS:C0225604" ; oboInOwl:hasExactSynonym "bronchi cartilage", "bronchial cartilage", "bronchial cartilage ring", "bronchial trunk cartilage", "bronchus cartilage", "cartilage of bronchi", "cartilage of bronchial trunk", "cartilagines bronchiales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001956" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "cartilage of bronchus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002185 ], _:genid121267 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0001957 obo:IAO_0000115 "A submucosa that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0002108", "EMAPA:37449", "FMA:62653", "MA:0001837", "NCIT:C49214", "SCTID:85546005", "UMLS:C0225601" ; oboInOwl:hasExactSynonym "bronchi submucosa", "bronchial submucosa", "bronchial trunk submucosa", "bronchus submucosa", "submucosa of bronchi", "submucosa of bronchial trunk", "tela submucosa bronchi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of bronchi" ; oboInOwl:id "UBERON:0001957" ; a owl:Class ; rdfs:label "submucosa of bronchus" ; rdfs:subClassOf obo:UBERON_0000009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0001958 obo:IAO_0000115 "An epithelium that lines a terminal bronchiole." ; obo:UBPROP_0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" ; oboInOwl:hasDbXref "EMAPA:36283", "FMA:62794", "MA:0001774", "NCIT:C33755", "UMLS:C1179400" ; oboInOwl:hasExactSynonym "bronchiolus terminalis epithelial tissue", "bronchiolus terminalis epithelium", "epithelial tissue of bronchiolus terminalis", "epithelial tissue of terminal bronchiole", "epithelium of bronchiolus terminalis", "epithelium of terminal bronchiole", "terminal bronchiole epithelial tissue", "terminal bronchiole epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001958" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "terminal bronchiole epithelium" ; rdfs:subClassOf _:genid121295 ; owl:equivalentClass _:genid120605 . obo:UBERON_0001959 obo:IAO_0000115 "The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies." ; obo:UBPROP_0000009 "The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located. [Wikipedia:White_pulp]" ; oboInOwl:hasDbXref "CALOHA:TS-1264", "EMAPA:35809", "FMA:62805", "MA:0000762", "NCIT:C12993", "UMLS:C0229686", "Wikipedia:White_pulp" ; oboInOwl:hasExactSynonym "pulpa alba", "spleen white pulp", "splenic white pulp", "white pulp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "noduli lymphoidei splenici" ; oboInOwl:id "UBERON:0001959" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "white pulp of spleen" ; rdfs:subClassOf obo:UBERON_1000023, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002106 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000542 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png"^^xsd:anyURI . obo:UBERON_0001961 obo:IAO_0000115 "Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." ; obo:IAO_0000116 "todo - add part relationships to specific layers" ; oboInOwl:hasDbXref "FMA:62819", "MA:0000140", "NCIT:C12910", "UMLS:C0599921", "Wikipedia:Mucosa-associated_lymphoid_tissue" ; oboInOwl:hasExactSynonym "MALT", "epithelio-lymphoid tissue", "mucosa associated lymphatic tissue", "mucosa associated lymphoid tissue", "mucosa-associated lymphoid tissue", "mucosal-associated lymphatic tissue", "mucosal-associated lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001961" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mucosa-associated lymphoid tissue" ; rdfs:subClassOf obo:UBERON_0012069, [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0046649 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000344 ] . obo:UBERON_0001962 obo:IAO_0000115 "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." ; obo:IAO_0000116 "phylogenetic relationships to be added" ; obo:UBPROP_0000008 "guts of jawless fish contains cells with lymphocyte-like morphology (Mayer 2002)." ; oboInOwl:hasDbXref "FMA:62820", "MA:0000136", "NCIT:C12936", "UMLS:C0596638", "Wikipedia:Gut-associated_lymphoid_tissue" ; oboInOwl:hasExactSynonym "gut associated lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "GALT" ; oboInOwl:id "UBERON:0001962" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gut-associated lymphoid tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0001963 obo:IAO_0000115 "A diffuse collection of lymphpoid cells that participate in airway immune responses." ; oboInOwl:hasDbXref "FMA:62821", "MA:0000135", "NCIT:C32234", "UMLS:C1179418" ; oboInOwl:hasExactSynonym "bronchus associated lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "BALT" ; oboInOwl:id "UBERON:0001963" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Lymphoid tissue associated with airways in mice has functional similarities to human BALT[ISBN:0123813611] Notes: FMA classifies this as organized, not diffuse" ; rdfs:label "bronchial-associated lymphoid tissue" ; rdfs:subClassOf _:genid121331 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid120641 ] . obo:UBERON_0001968 obo:IAO_0000115 "Organism substance that is composed of sperm cells suspended in seminal fluid." ; obo:UBPROP_0000007 "seminal" ; obo:UBPROP_0000008 "Note that in this ontology, semen is defined as the sum of sperm and seminal fluid, where seminal fluid is defined in taxonomically generic way (see comments for UBERON:0006530)." ; oboInOwl:hasDbXref "BTO:0001230", "CALOHA:TS-0917", "EMAPA:31488", "FMA:62966", "GAID:1169", "MA:0002522", "MESH:D012661", "NCIT:C13277", "NCIT:C13713", "UMLS:C1518159", "UMLS:C2756969", "Wikipedia:Semen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ejaculate", "sperm" ; oboInOwl:id "UBERON:0001968" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "semen" ; rdfs:subClassOf obo:UBERON_0000463, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000019 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006530 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0042713 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/40/Human_semen_in_petri_dish2.jpg"^^xsd:anyURI . obo:UBERON_0001969 obo:IAO_0000115 "The liquid component of blood, in which erythrocytes are suspended." ; oboInOwl:hasBroadSynonym "plasma", "portion of plasma" ; oboInOwl:hasDbXref "BTO:0000131", "CALOHA:TS-0800", "EFO:0001905", "EMAPA:35690", "FMA:62970", "GAID:1178", "MA:0002501", "MAT:0000052", "MESH:D010949", "MIAA:0000052", "NCIT:C13356", "UMLS:C0032105", "Wikipedia:Blood_plasma" ; oboInOwl:hasExactSynonym "blood plasm", "portion of blood plasma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001969" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "blood plasma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000178 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005577 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:CL_0000232 ] ) ] . obo:UBERON_0001970 obo:IAO_0000115 "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." ; obo:UBPROP_0000008 "In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum." ; obo:UBPROP_0000009 "aids the process of digestion of lipids in the small intestine", "bile salts function to emulsify dietary fats and facilitate their intestinal absorption", "elimination of cholesterol", "major excretory route for potentially harmful exogenous lipophilic substances", "many hormones and pheromones are excreted in bile, and contribute to growth and development of the intestine in some species and provide attractants for the weaning of non-human vertebrates", "protects the organism from enteric infections by excreting immune globulin A (IgA), inflammatory cytokines, and stimulating the innate immune system in the intestine" ; oboInOwl:hasDbXref "BTO:0000121", "CALOHA:TS-1172", "ENVO:02000023", "FMA:62971", "GAID:1157", "MA:0002513", "MESH:D001646", "NCIT:C13192", "UMLS:C0005388", "Wikipedia:Bile", "ZFA:0005857", "galen:Bile" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fel", "gall" ; oboInOwl:id "UBERON:0001970" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "bile" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_22868 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_36277 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001735 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007586 ], _:genid121360 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0001971 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "BTO:0000501", "FMA:62972", "GAID:1160", "MA:0002519", "MESH:D005750", "NCIT:C32661", "UMLS:C0017133", "Wikipedia:Gastric_juice", "galen:GastricJuice" ; oboInOwl:hasExactSynonym "stomach secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "succus gastricus" ; oboInOwl:id "UBERON:0001971" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gastric juice" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0011953 ] ) ] . obo:UBERON_0001972 obo:IAO_0000115 "A submucosa that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0002109", "EMAPA:35325", "FMA:62997", "MA:0002724", "SCTID:362128009" ; oboInOwl:hasExactSynonym "esophageal submucosa", "esophagus submucosa", "gullet submucosa", "oesophagus submucosa", "submucosa of esophagus", "submucosa of gullet", "submucosa of oesophagus", "tela submucosa (oesophagus)", "tela submucosa esophagi", "tela submucosa oesophageae", "tela submucosa of esophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of esophagus", "tela submucosa oesophagi" ; oboInOwl:id "UBERON:0001972" ; a owl:Class ; rdfs:label "submucosa of esophagus" ; rdfs:subClassOf obo:UBERON_0000009, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001096 ] ; owl:equivalentClass _:genid120688 . obo:UBERON_0001974 obo:IAO_0000115 "A lamina propria that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:26987", "FMA:63050", "MA:0001568", "NCIT:C49223", "UMLS:C1707949" ; oboInOwl:hasExactSynonym "esophagus lamina propria", "esophagus lamina propria mucosa", "esophagus lamina propria mucosae", "gullet lamina propria", "gullet lamina propria mucosa", "gullet lamina propria mucosae", "lamina propria mucosa of esophagus", "lamina propria mucosa of gullet", "lamina propria mucosa of oesophagus", "lamina propria mucosae of esophagus", "lamina propria mucosae of gullet", "lamina propria mucosae of oesophagus", "lamina propria of gullet", "lamina propria of oesophagus", "oesophagus lamina propria mucosa", "oesophagus lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "esophageal lamina propria", "oesophagus lamina propria" ; oboInOwl:id "UBERON:0001974" ; a owl:Class ; rdfs:label "lamina propria of esophagus" ; rdfs:subClassOf obo:UBERON_0000030, _:genid121396 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0001975 obo:IAO_0000115 "A serous membrane that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35322", "FMA:63057", "MA:0001571" ; oboInOwl:hasExactSynonym "esophagus serosa", "esophagus serous membrane", "gullet serosa", "gullet serous membrane", "oesophagus serous membrane", "serosa of abdominal part of esophagus", "serosa of gullet", "serosa of oesophagus", "serous coat of oesophagus", "serous membrane of esophagus", "serous membrane of gullet", "serous membrane of oesophagus", "tunica serosa oesophageae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oesophagus serosa" ; oboInOwl:id "UBERON:0001975" ; a owl:Class ; rdfs:label "serosa of esophagus" ; rdfs:subClassOf obo:UBERON_0000042, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001096 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0001976 obo:IAO_0000115 "The epithelial layer that lines the luminal space of the esophagus." ; obo:IAO_0000116 "TODO check epithelium types: in FMA: Nonkeratinizing stratified squamous epithelium; mouse has basal and squamous subtypes; in ZFA it is columnar" ; obo:UBPROP_0000001 "Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO]" ; oboInOwl:hasDbXref "BTO:0001578", "CALOHA:TS-0698", "EFO:0003041", "EHDAA2:0001287", "EMAPA:16835", "FMA:63063", "MA:0001565", "NCIT:C49221", "TAO:0001499", "UMLS:C1179544", "ZFA:0001499" ; oboInOwl:hasExactSynonym "epithelial tissue of esophagus", "epithelial tissue of gullet", "epithelial tissue of oesophagus", "epithelium of gullet", "epithelium of oesophagus", "esophageal epithelium", "esophagus epithelial tissue", "esophagus epithelium", "gullet epithelial tissue", "gullet epithelium", "oesophagus epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oesophagus epithelium" ; oboInOwl:id "UBERON:0001976" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "epithelium of esophagus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001043 ], _:genid121434 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0001977 obo:IAO_0000115 "The portion of blood plasma that excludes clotting factors." ; oboInOwl:hasDbXref "BTO:0000133", "BTO:0001239", "CALOHA:TS-0923", "EHDAA2:0004728", "EMAPA:35770", "FMA:63083", "MA:0002502", "MESH:D044967", "NCIT:C13325", "UMLS:C0229671", "Wikipedia:Serum_(blood)" ; oboInOwl:hasExactSynonym "serum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001977" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "blood serum" ; rdfs:subClassOf obo:UBERON_0000463, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001969 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ] . obo:UBERON_0001978 oboInOwl:hasDbXref "EMAPA:32925", "FMA:63120", "MA:0000724", "SCTID:371401008", "VHOG:0001430" ; oboInOwl:hasExactSynonym "pancreas parenchyma", "pancreatic parenchyma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001978" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "parenchyma of pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0001979 obo:IAO_0000115 "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." ; obo:UBPROP_0000001 "Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO]" ; oboInOwl:hasDbXref "BTO:0002626", "EMAPA:35917", "FMA:63130", "MA:0000071", "MESH:D014699", "NCIT:C12818", "SCTID:341687009", "TAO:0005315", "UMLS:C0042520", "VHOG:0001765", "Wikipedia:Venule", "ZFA:0005315" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venula" ; oboInOwl:id "UBERON:0001979" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "venule" ; rdfs:subClassOf obo:UBERON_0003920, obo:UBERON_8410081, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001638 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001982 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg"^^xsd:anyURI . obo:UBERON_0001980 obo:IAO_0000115 "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." ; obo:UBPROP_0000001 "Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO]", "Small, terminal branch of an artery which generally connects to capillaries.[AAO]" ; oboInOwl:hasDbXref "AAO:0010253", "BTO:0001997", "EMAPA:35146", "FMA:63182", "MA:0000063", "MESH:D001160", "NCIT:C12672", "SCTID:337724002", "TAO:0002138", "UMLS:C0003847", "VHOG:0001763", "Wikipedia:Arteriole", "ZFA:0005255" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriola" ; oboInOwl:id "UBERON:0001980" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "arteriole" ; rdfs:subClassOf obo:UBERON_0003509, obo:UBERON_8410081, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001637 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001637 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001982 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg"^^xsd:anyURI . obo:UBERON_0001981 obo:IAO_0000115 "A vessel through which blood circulates in the body." ; obo:IAO_0000116 "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" ; obo:UBPROP_0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]", "Any of the vessels through which blood circulates in the body.[AAO]" ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; obo:UBPROP_0000008 "annelids have blood vessels, but this class is not applicable to annelids." ; obo:UBPROP_0000012 "FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX" ; oboInOwl:hasBroadSynonym "vascular element" ; oboInOwl:hasDbXref "AAO:0011004", "AEO:0000207", "BTO:0001102", "CALOHA:TS-0080", "EFO:0000817", "EHDAA2:0003252", "EHDAA:240", "EMAPA:32743", "EMAPA:35993", "FMA:50722", "FMA:63183", "GAID:169", "MA:0000060", "MAT:0000393", "MESH:D001808", "NCIT:C12679", "NLXANAT:090901", "SCTID:361097006", "TAO:0002137", "UMLS:C0005847", "VHOG:0001250", "Wikipedia:Blood_vessel", "XAO:0001011", "ZFA:0005314" ; oboInOwl:hasExactSynonym "region of vascular tree organ", "vascular tree organ region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vas sanguineum" ; oboInOwl:id "UBERON:0001981" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "blood vessel" ; rdfs:subClassOf obo:UBERON_0000055, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004537 ], _:genid120787, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004872 ], _:genid120789, [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0000178 ], _:genid121478, _:genid121480, _:genid121484 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg"^^xsd:anyURI . obo:UBERON_0001982 obo:IAO_0000115 "Any of the smallest blood vessels connecting arterioles with venules." ; obo:IAO_0000116 "not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element" ; obo:UBPROP_0000001 "Any of the tiny blood vessels connecting the arterioles to the venules.[AAO]" ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; obo:UBPROP_0000010 "capillaries lack tunica media and tunica adventitia; only the endothelial wall of the tunica intima belongs" ; oboInOwl:hasDbXref "AAO:0010252", "BTO:0002045", "CALOHA:TS-2006", "EFO:0001906", "EMAPA:35198", "EV:0100035", "FMA:63194", "MA:0000065", "MESH:D002196", "NCIT:C12685", "NLXANAT:090902", "TAO:0005250", "UMLS:C0935624", "VHOG:0001253", "Wikipedia:Capillary", "XAO:0000116", "ZFA:0005250" ; oboInOwl:hasExactSynonym "blood capillary", "capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001982" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "capillary" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/2186" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_8410081 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001980 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg"^^xsd:anyURI . obo:UBERON_0001985 obo:IAO_0000115 "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." ; oboInOwl:hasDbXref "CALOHA:TS-0172", "EMAPA:35935", "FMA:63882", "GAID:891", "MA:0001242", "MESH:D004728", "NCIT:C12707", "SCTID:368827009", "TAO:0002186", "UMLS:C0014259", "Wikipedia:Corneal_endothelium", "ZFA:0001687" ; oboInOwl:hasExactSynonym "cornea endothelium", "endothelium of cornea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium posterius corneae" ; oboInOwl:id "UBERON:0001985" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "corneal endothelium" ; rdfs:subClassOf obo:UBERON_0001986, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001766 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000964 ], _:genid121512 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid120815 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png"^^xsd:anyURI . obo:UBERON_0001986 obo:IAO_0000115 "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." ; obo:UBPROP_0000007 "endothelial" ; oboInOwl:hasDbXref "BTO:0000393", "CALOHA:TS-0278", "EFO:0002548", "FMA:63916", "GAID:520", "MESH:D004727", "NCIT:C12481", "SCTID:27168002", "UMLS:C0014257", "galen:Endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001986" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)" ; rdfs:label "endothelium" ; rdfs:subClassOf obo:UBERON_0000487, _:genid121526 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000115 ] ) ] . obo:UBERON_0001987 obo:IAO_0000115 "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." ; obo:UBPROP_0000003 "Phylogenetic analyses of the concatenated data set using maximum parsimony, maximum likelihood and distance based (neighbour joining) methods all converged on a nearly identical, well supported topology defining four principal eutherian lineages. The results affirm monophyly of traditional placental orders (except Artiodactyla and Insectivora), and also support some previously proposed, as well as new, superordinal clades.[well established][VHOG]" ; obo:UBPROP_0000007 "placental" ; obo:UBPROP_0000008 "Eutherians: In eutherians, the chorioallantoic membrane of the fetus establishes intimate contact with the adjacent vascular wall of the mother's uterus to produce the placenta, a composite structure formed in part from tissues of the fetus and in part from tissues of the mother [ISBN:0073040584 (Vertebrates, Kardong)]. TODO - is taxon restriction too strict, even if we restrict def to allantoic placenta? - WP says: also found in some snakes and lizards with varying levels of development up to mammalian levels. Pough et al. 1992. Herpetology: Third Edition. Pearson Prentice Hall:Pearson Education, Inc., 2002. // See also: DOI:10.1002/jmor.11011" ; oboInOwl:hasDbXref "BTO:0001078", "CALOHA:TS-0799", "EFO:0001407", "EMAPA:35689", "EV:0100119", "FMA:63934", "GAID:379", "MA:0000386", "MAT:0000279", "MESH:D010920", "MIAA:0000279", "NCIT:C13272", "SCTID:181455002", "UMLS:C0032043", "VHOG:0001266", "Wikipedia:Placenta" ; oboInOwl:hasExactSynonym "allantoic placenta", "eutherian placenta" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001987" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Marsupials possess only a rudimentary yolk-type placenta, with reduced nutrient and oxygen exchanging capabilities." ; rdfs:label "placenta" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ], _:genid121532, _:genid121534, _:genid121536 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Placenta.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/f/f1/Placenta.svg"^^xsd:anyURI . obo:UBERON_0001988 obo:IAO_0000115 "Portion of semisolid bodily waste discharged through the anus[MW,modified]." ; obo:UBPROP_0000001 "Excretion in semisolid state processed by the intestine.[FMA]" ; obo:UBPROP_0000007 "fecal" ; oboInOwl:hasBroadSynonym "excreta" ; oboInOwl:hasDbXref "BTO:0000440", "CALOHA:TS-2345", "ENVO:00002003", "FMA:64183", "GAID:1199", "MA:0002509", "MAT:0000053", "MESH:D005243", "MIAA:0000053", "NCIT:C13234", "UMLS:C0015733", "Wikipedia:Feces", "galen:Feces" ; oboInOwl:hasExactSynonym "faeces", "fecal material", "fecal matter", "piece of shit", "portion of excrement", "portion of faeces", "portion of fecal material", "portion of fecal matter", "portion of feces", "portionem cacas", "stool" ; oboInOwl:hasNarrowSynonym "cow dung", "cow pat", "dung", "fewmet", "frass", "guano", "portion of dung", "portion of guano", "portion of scat", "scat", "spraint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "droppings", "excrement", "ordure", "spoor" ; oboInOwl:id "UBERON:0001988" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "feces" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000174 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0030421 ] ) ] . obo:UBERON_0001994 obo:IAO_0000115 "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." ; obo:UBPROP_0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783].", "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.[VSAO]" ; oboInOwl:hasDbXref "EMAPA:35414", "FMA:64783", "MA:0000109", "NCIT:C32746", "SCTID:39298000", "UMLS:C0225362", "VSAO:0000094", "Wikipedia:Hyaline_cartilage", "XAO:0004029" ; oboInOwl:hasExactSynonym "hyaline cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chondroid cartilage" ; oboInOwl:id "UBERON:0001994" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hyaline cartilage tissue" ; rdfs:subClassOf obo:UBERON_0002418, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000138 ], _:genid121560 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray292.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg"^^xsd:anyURI . obo:UBERON_0001995 obo:IAO_0000115 "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." ; obo:UBPROP_0000001 "A mixture of white fibrous tissue and cartilaginous tissue in various proportions. It owes its flexibility and toughness to the former of these constituents, and its elasticity to the latter. It is the only type of cartilage that contains type I collagen in addition to the normal type I[Wikipedia:Fibrocartilage]I", "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel without a well-defined perichondrium[FMA:64784].", "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns.[VSAO]" ; obo:UBPROP_0000007 "fibrocartilaginous" ; oboInOwl:hasDbXref "FMA:64784", "MA:0000108", "MESH:D051445", "NCIT:C32599", "SCTID:91685003", "UMLS:C0684077", "VSAO:0000103", "Wikipedia:Fibrocartilage", "XAO:0004028", "galen:Fibrocartilage" ; oboInOwl:hasExactSynonym "fibrocartilage tissue", "stratified cartilage tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0001995" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The white fibrocartilages admit of arrangement into four groups-interarticular, connecting, circumferential, and stratiform -- WP. EDITOR NOTE: TODO add mineralized" ; rdfs:label "fibrocartilage" ; rdfs:subClassOf obo:UBERON_0002418, _:genid120868, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005584 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray295.png"^^xsd:anyURI . obo:UBERON_0001996 obo:IAO_0000115 "Cartilage tissue that is flexible and contains abundant elastic fibers." ; obo:UBPROP_0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which consists of elastic fibers[FMA:64785].", "Cartilage tissue that is flexible and contains abundant elastic fibers.[VSAO]" ; obo:UBPROP_0000012 "MA has a distinct class for yellow" ; oboInOwl:hasDbXref "FMA:64785", "MA:0000107", "MA:0000485", "NCIT:C32494", "UMLS:C0682559", "VSAO:0000091", "Wikipedia:Elastic_cartilage", "XAO:0004197" ; oboInOwl:hasExactSynonym "elastic cartilage", "elastic cartilage tissue", "yellow elastic cartilage", "yellow elastic cartilage tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "reticular cartilage", "yellow cartilage" ; oboInOwl:id "UBERON:0001996" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "elastic cartilage tissue" ; rdfs:subClassOf obo:UBERON_0011589, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001544 ], _:genid121578, _:genid121581 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray904.png"^^xsd:anyURI . obo:UBERON_0002000 obo:IAO_0000115 "On of the muscles that make up the buttocks: the gluteus maximus muscle, gluteus medius muscle and gluteus minimus muscle." ; obo:UBPROP_0000007 "gluteal" ; obo:UBPROP_0000012 "FMA includes tensor fasciae latae and other buttock muscles. BTO def: Any one of three large skeletal muscles that form the buttock and move the thigh." ; oboInOwl:hasDbXref "BTO:0000531", "EHDAA2:0000715", "EMAPA:18186", "FMA:64922", "MA:0000535", "NCIT:C78205", "UMLS:C1744702", "VHOG:0001316", "Wikipedia:Gluteal_muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gluteus", "gluteus muscle" ; oboInOwl:id "UBERON:0002000" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gluteal muscle" ; rdfs:subClassOf _:genid121597 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001497 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013691 ] ) ] . obo:UBERON_0002001 obo:IAO_0000115 "Any joint that connects a rib to another structure (or another rib). Examples: costochondral, costovertebral, interchondral, sternocostal joints." ; oboInOwl:hasDbXref "FMA_RETIRED:64994", "MA:0001508", "NCIT:C49575", "SCTID:263314001", "UMLS:C1261194" ; oboInOwl:hasExactSynonym "rib joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002001" ; a owl:Class ; rdfs:label "joint of rib" ; rdfs:subClassOf obo:UBERON_0000982, _:genid121607 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002228 ] ) ] . obo:UBERON_0002004 oboInOwl:hasDbXref "EMAPA:18577", "FMA:65507", "MA:0001178" ; oboInOwl:hasExactSynonym "sciatic nerve trunk", "sciatic neural trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002004" ; a owl:Class ; rdfs:label "trunk of sciatic nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid120908 ] . obo:UBERON_0002005 obo:IAO_0000115 "The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO]." ; obo:UBPROP_0000012 "most sources classify this as autonomic, but in FMA it is placed directly under nervous system." ; oboInOwl:hasDbXref "BAMS:ENS", "BIRNLEX:1166", "BTO:0002506", "CALOHA:TS-2093", "EFO:0000895", "EHDAA2:0004202", "EMAPA:26922", "FMA:66070", "GAID:799", "MA:0000222", "MAT:0000102", "MESH:D017615", "MIAA:0000102", "TAO:0001155", "UMLS:C0206111", "Wikipedia:Enteric_nervous_system", "ZFA:0001155" ; oboInOwl:hasExactSynonym "PNS - enteric", "enteric PNS" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002005" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "enteric nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002410 ], _:genid121616, _:genid121618 . obo:UBERON_0002006 obo:IAO_0000115 "Peripheral portion of the lymph node, underneath the capsule[WP]." ; oboInOwl:hasDbXref "EMAPA:35525", "FMA:66253", "MA:0000740", "NCIT:C33029", "UMLS:C0933402", "Wikipedia:Cortex_of_lymph_node" ; oboInOwl:hasExactSynonym "lymph node cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortex nodi lymphoidei" ; oboInOwl:id "UBERON:0002006" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cortex of lymph node" ; rdfs:subClassOf obo:UBERON_0001851, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png"^^xsd:anyURI . obo:UBERON_0002007 obo:IAO_0000115 "The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." ; oboInOwl:hasDbXref "EMAPA:35529", "FMA:66254", "MA:0000745" ; oboInOwl:hasExactSynonym "lymph node medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medulla nodi lymphoidei" ; oboInOwl:id "UBERON:0002007" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "medulla of lymph node" ; rdfs:subClassOf _:genid120932, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0009745 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid120929 ] . obo:UBERON_0002008 obo:IAO_0000115 "A plexus of nerves situated at the base of the heart that innervate the heart." ; oboInOwl:hasDbXref "EMAPA:37460", "FMA:6628", "MA:0001138", "NCIT:C52833", "SCTID:280511002", "UMLS:C0459528", "Wikipedia:Cardiac_plexus" ; oboInOwl:hasExactSynonym "autonomic nerve plexus of heart", "autonomic plexus of heart", "cardiac plexus", "heart autonomic nerve plexus", "heart autonomic plexus", "plexus cardiacus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002008" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "cardiac nerve plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001816 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png"^^xsd:anyURI . obo:UBERON_0002011 obo:IAO_0000115 "The thoracodorsal artery is a branch of the subscapular artery. It travels inferiorly with the thoracodorsal nerve and supplies the latissimus dorsi. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37129", "FMA:66320", "MA:0002065", "NCIT:C53018", "UMLS:C0933449", "Wikipedia:Thoracodorsal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria thoracodorsalis" ; oboInOwl:id "UBERON:0002011" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "thoracodorsal artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001112 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png"^^xsd:anyURI . obo:UBERON_0002012 obo:IAO_0000115 "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." ; obo:UBPROP_0000001 "Major artery which supplies blood to the lungs.[AAO]", "One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG]" ; obo:UBPROP_0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" ; obo:UBPROP_0000008 "In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung[WP]" ; oboInOwl:hasDbXref "AAO:0010221", "BTO:0000778", "CALOHA:TS-0839", "EFO:0001399", "EHDAA2:0001575", "EHDAA:4351", "EMAPA:17008", "FMA:66326", "GAID:505", "MA:0002031", "MESH:D011651", "NCIT:C12774", "SCTID:181380003", "UMLS:C0034052", "VHOG:0000982", "Wikipedia:Pulmonary_artery", "XAO:0004162", "galen:PulmonaryArtery" ; oboInOwl:hasExactSynonym "pulmonary arterial tree", "pulmonary arterial tree organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria pulmonalis", "pulmonary arterial subtree", "truncus pulmonalis" ; oboInOwl:id "UBERON:0002012" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pulmonary artery" ; rdfs:subClassOf obo:UBERON_0013768, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002333 ], _:genid121670, _:genid121672, _:genid121674 ; owl:disjointWith obo:UBERON_0004573 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008886 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0002015 obo:IAO_0000115 "The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage." ; obo:UBPROP_0000009 "provides some protection from trauma and damage." ; obo:UBPROP_0000010 "The renal capsule relates to the other layers in the following order (moving from innermost to outermost): renal medulla renal cortex renal capsule perinephric fat (or 'perirenal fat') renal fascia paranephric fat (or 'pararenal fat') peritoneum (anteriorly), and transversalis fascia (posteriorly).[Wikipedia:Kidney_capsule]" ; oboInOwl:hasDbXref "EMAPA:18679", "FMA:66610", "MA:0000370", "NCIT:C12885", "SCTID:243657006", "UMLS:C0227637", "Wikipedia:Kidney_capsule", "galen:CapsuleOfKidney" ; oboInOwl:hasExactSynonym "capsula fibrosa renis", "capsule of kidney", "fibrous capsule of kidney", "renal capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002015" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "kidney capsule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011824 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg"^^xsd:anyURI . obo:UBERON_0002016 obo:IAO_0000115 "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." ; obo:UBPROP_0000001 "Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO]", "One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG]", "the veins that return oxygenated blood from the lungs to the left atrium of the heart" ; obo:UBPROP_0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" ; obo:UBPROP_0000202 obo:FMA_70827 ; oboInOwl:hasDbXref "AAO:0010521", "BTO:0001799", "CALOHA:TS-0840", "EHDAA2:0001579", "EHDAA:2629", "EMAPA:18645", "FMA:66643", "GAID:543", "MA:0002206", "MESH:D011667", "NCIT:C12776", "SCTID:430160002", "UMLS:C0034090", "VHOG:0001133", "Wikipedia:Pulmonary_vein", "XAO:0000394", "galen:PulmonaryVein" ; oboInOwl:hasExactSynonym "pulmonary venous tree organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae pulmonales" ; oboInOwl:id "UBERON:0002016" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pulmonary vein" ; rdfs:subClassOf obo:UBERON_0013768, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008886 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002079 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002061 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0002017 obo:IAO_0000115 "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." ; oboInOwl:hasDbXref "BTO:0001792", "CALOHA:TS-0814", "EHDAA2:0001485", "EHDAA:6510", "EMAPA:17349", "FMA:66645", "GAID:540", "MA:0002198", "MESH:D011169", "NCIT:C33343", "SCTID:362064007", "UMLS:C0032718", "VHOG:0000656", "XAO:0000392", "galen:PortalVein" ; oboInOwl:hasExactSynonym "portal venous tree organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002017" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "portal vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005806 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png"^^xsd:anyURI . obo:UBERON_0002019 obo:IAO_0000115 "A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord." ; obo:UBPROP_0000001 "A small motor nerve which emerges from the lateral wall of the medulla with the roots of the vagus nerve, and innervates a single pectoral suspensory muscle, the m.cucullaris.", "Cranial nerve that innervates the sternocleidomastoid and trapezius complex of muscles. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-1, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]", "Small motor nerve which innervates a single pectoral suspensory muscle, the m. cucullaris.[AAO]" ; obo:UBPROP_0000003 "Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG]" ; obo:UBPROP_0000008 "In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve" ; obo:UBPROP_0000012 "FMA has distinct cranial and spinal parts - WP says 'Traditional descriptions of the accessory nerve divide it into two parts: a spinal part and a cranial part.[1] However, because the cranial component rapidly joins the vagus nerve, becoming an integral part of said nerve, modern descriptions often consider the cranial component to be part of the vagus nerve and not part of the accessory nerve proper.[2]" ; oboInOwl:hasDbXref "AAO:0010476", "BAMS:11n", "BAMS:XIn", "BIRNLEX:812", "EHDAA2:0000106", "EHDAA:2855", "EMAPA:17265", "FMA:6720", "FMA:80284", "GAID:825", "HBA:9340", "MA:0001088", "MBA:717", "MESH:D000055", "NCIT:C32041", "SCTID:362469008", "UMLS:C0000905", "UMLS:C1305777", "VHOG:0000699", "Wikipedia:Spinal_accessory_nerve", "XAO:0004214", "neuronames:2085" ; oboInOwl:hasExactSynonym "Willis' nerve", "accessory XI", "accessory XI nerve", "accessory nerve", "accessory nerve [XI]", "cervical accessory nerve", "cranial nerve XI", "eleventh cranial nerve", "nervus accessorius [XI]", "pars spinalis nervus accessorius", "radix spinalis nervus accessorius", "spinal accessory nerve", "spinal accessory nerve tree", "spinal part of accessory nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CN-XI", "accessory spinal nerve" ; oboInOwl:id "UBERON:0002019" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "accessory XI nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001737 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0020358 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png"^^xsd:anyURI . obo:UBERON_0002020 obo:IAO_0000115 "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." ; obo:UBPROP_0000001 "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" ; oboInOwl:hasDbXref "AEO:0001012", "EHDAA2:0003136", "EHDAA2_RETIRED:0004658", "EMAPA:37596", "FMA:67242", "HBA:4006", "MA:0001112", "MESH:D066128", "NCIT:C32695", "TAO:0002197", "UMLS:C0018220", "VHOG:0001768", "Wikipedia:Gray_matter", "ZFA:0001681", "neuronames:2869" ; oboInOwl:hasExactSynonym "gray matter", "gray matter of neuraxis", "grey matter", "grey matter of neuraxis", "grey substance", "neuronal grey matter", "substantia grisea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gray mater", "grisea" ; oboInOwl:id "UBERON:0002020" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "gray matter" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0043025 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg"^^xsd:anyURI . obo:UBERON_0002025 obo:IAO_0000115 "The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells." ; obo:UBPROP_0000009 "replaces damaged cells on outside of body" ; obo:UBPROP_0000010 "consisting of non-keratinized, viable cells, in contrast to the outer (upper) layer of epidermis made up of keratinized, anucleated, non-viable cells" ; oboInOwl:hasBroadSynonym "Malpighian layer", "rete Malphighii", "rete Malpighii", "stratum Malpighi", "stratum basale", "stratum germinosum" ; oboInOwl:hasDbXref "AAO:0010598", "BTO:0000438", "EMAPA:32779", "FMA:67540", "MA:0000803", "NCIT:C33466", "NCIT:C33623", "SCTID:419481005", "TAO:0001180", "UMLS:C0221925", "Wikipedia:Stratum_germinativum", "XAO:0000041", "ZFA:0001180" ; oboInOwl:hasExactSynonym "basal cell layer of epidermis", "basal epidermal layer", "epidermal basal stratum", "epidermis stratum basale", "stratum basalis of epidermis", "stratum germinativum", "stratum germinosum of epidermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal cell layer of skin", "basal layer of epidermis", "epidermis basal layer", "epidermis sensorial layer", "epidermis stratum germinativum" ; oboInOwl:id "UBERON:0002025" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "stratum basale of epidermis" ; rdfs:subClassOf _:genid121044, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000148 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000242 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013754 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002187 ] ) ] . obo:UBERON_0002026 obo:IAO_0000115 "The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance." ; obo:UBPROP_0000009 "Has cells that produce and secrete bipolar lipids which prevent evaporation, helping to 'water-proof' the skin. Keratinization begins in the stratum spinosum. [Wikipedia:Stratum_spinosum]" ; oboInOwl:hasBroadSynonym "Malpighian layer", "stratum Malpighii" ; oboInOwl:hasDbXref "BTO:0000435", "EMAPA:32785", "FMA:67542", "MA:0000807", "NCIT:C12850", "SCTID:420086000", "UMLS:C0221924", "Wikipedia:Stratum_spinosum" ; oboInOwl:hasExactSynonym "epidermis stratum spinosum", "prickle cell layer of epidermis", "squamous cell layer of epidermis", "stratum spinosum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epidermis prickle cell layer", "prickle cell layer" ; oboInOwl:id "UBERON:0002026" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "stratum spinosum of epidermis" ; rdfs:subClassOf _:genid121060, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000453 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002025 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002069 ] ; owl:equivalentClass _:genid121056 . obo:UBERON_0002027 obo:IAO_0000115 "The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells." ; obo:UBPROP_0000001 "The keratinized outermost layer of the epidermis, which is periodically shed.[AAO]" ; obo:UBPROP_0000010 "some oral epitehlium also has cornified layer / stratum corneum" ; oboInOwl:hasBroadSynonym "horny layer", "keratinized squame layer", "stratum corneum" ; oboInOwl:hasDbXref "AAO:0010597", "BTO:0000344", "CALOHA:TS-0981", "EMAPA:32787", "FMA:67545", "MA:0000804", "NCIT:C33625", "SCTID:361695002", "UMLS:C0221921", "Wikipedia:Stratum_corneum" ; oboInOwl:hasExactSynonym "cornified layer", "epidermis stratum corneum", "horny layer of epidermis", "keratinized squame layer of epidermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "stratum corneum epidermidis" ; oboInOwl:id "UBERON:0002027" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "stratum corneum of epidermis" ; rdfs:subClassOf obo:UBERON_0003055, obo:UBERON_0013754, [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0031424 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0002069 ], _:genid121779 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Skinlayers.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/e/e4/Epidermal_layers.png"^^xsd:anyURI . obo:UBERON_0002028 obo:IAO_0000115 "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." ; obo:RO_0002171 obo:UBERON_0001891, obo:UBERON_0001894 ; obo:UBPROP_0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]", "The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO]" ; obo:UBPROP_0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" ; obo:UBPROP_0000007 "rhombencephalic" ; obo:UBPROP_0000012 "in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps" ; oboInOwl:hasDbXref "AAO:0010150", "BAMS:HB", "BIRNLEX:942", "BTO:0000672", "CALOHA:TS-0457", "DHBA:10653", "DMBA:16808", "EFO:0000923", "EHDAA2:0000746", "EHDAA:3514", "EHDAA:6487", "EMAPA:16916", "FMA:67687", "MA:0000195", "MAT:0000107", "MBA:1065", "MESH:D012249", "MIAA:0000107", "NCIT:C40336", "SCTID:303456008", "TAO:0000029", "UMLS:C0035507", "UMLS:C1522180", "VHOG:0000070", "Wikipedia:Rhombencephalon", "XAO:0000015", "ZFA:0000029", "neuronames:540" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombencephalon" ; oboInOwl:id "UBERON:0002028" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hindbrain" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ], _:genid121789, _:genid121791, _:genid121794 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg"^^xsd:anyURI . obo:UBERON_0002029 obo:IAO_0000115 "The simple columnar epithelial lining of the gall bladder." ; oboInOwl:hasDbXref "BTO:0001449", "CALOHA:TS-1304", "EMAPA:35370", "FMA:67711", "MA:0001632", "NCIT:C49227", "UMLS:C1180206" ; oboInOwl:hasExactSynonym "epithelial tissue of gall bladder", "epithelial tissue of gallbladder", "epithelium of gallbladder", "gall bladder epithelial tissue", "gall bladder epithelium", "gallbladder epithelial tissue", "gallbladder epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary epithelium" ; oboInOwl:id "UBERON:0002029" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of gall bladder" ; rdfs:subClassOf obo:UBERON_0000485, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0002030 obo:IAO_0000115 "Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip." ; obo:UBPROP_0000008 "a male mouse has no nipples - mammary tissue regresses during embryonic development" ; obo:UBPROP_0000012 "FMA makes this part of the breast, whereas in MA it is part of the mammary gland -" ; oboInOwl:hasDbXref "BTO:0000821", "CALOHA:TS-2234", "EMAPA:36508", "FMA:67771", "GAID:35", "MA:0000796", "MESH:D009558", "NCIT:C12299", "SCTID:265780004", "UMLS:C0028109", "Wikipedia:Nipple", "galen:Nipple" ; oboInOwl:hasExactSynonym "papilla mammae", "papilla of breast", "thele", "thelium" ; oboInOwl:hasNarrowSynonym "papillary part of breast", "teat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "papilla mammaria" ; oboInOwl:id "UBERON:0002030" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Nipple being part_of mammary gland is due to a practical modelling in uberon that treats mammary gland as including adnexa. A GCI asserts that nipple is part of the breast in humans. For discussion of this, please refer to https://github.com/obophenotype/uberon/issues/1873." ; rdfs:label "nipple" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/1873" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ], _:genid121822 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/59/Female_nipple_profile.jpg"^^xsd:anyURI . obo:UBERON_0002031 obo:IAO_0000115 "An epithelium that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001845", "CALOHA:TS-1240", "EFO:0000307", "EMAPA:32691", "FMA:67782", "MA:0001839", "NCIT:C32231", "UMLS:C0599333" ; oboInOwl:hasExactSynonym "bronchi epithelial tissue", "bronchi epithelium", "bronchial epithelium", "bronchial trunk epithelial tissue", "bronchial trunk epithelium", "bronchus epithelial tissue", "bronchus epithelium", "epithelial tissue of bronchi", "epithelial tissue of bronchial trunk", "epithelial tissue of bronchus", "epithelium of bronchi", "epithelium of bronchial trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002031" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of bronchus" ; rdfs:subClassOf obo:UBERON_0000485, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002185 ], _:genid121836 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0002032 obo:IAO_0000115 "Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple." ; obo:UBPROP_0000007 "areolar" ; oboInOwl:hasDbXref "FMA:67796", "MA:0000788", "NCIT:C12368", "UMLS:C0222608", "Wikipedia:Areola" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "areola mammae", "areolae" ; oboInOwl:id "UBERON:0002032" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "areola" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001911 ], _:genid121851 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Brustwarze.JPG"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/a/ad/Female_Areola.jpg"^^xsd:anyURI . obo:UBERON_0002033 obo:IAO_0000115 "A tiny smooth muscle that connects the hair follicle with the dermis." ; obo:UBPROP_0000009 "When contracted the arrector pili causes the raising of the hair" ; oboInOwl:hasDbXref "BTO:0005132", "EMAPA:26775", "FMA:67821", "MA:0000778", "SCTID:319910005", "Wikipedia:Arrector_pili_muscle" ; oboInOwl:hasExactSynonym "arrector pili", "arrector pili muscle", "arrector pili smooth muscle", "arrector pilli", "arrector pilli muscle", "arrector pilorum", "arrector pilorum muscle of hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arectores pilorum", "erector pili", "erectores pilorum", "pilomotor muscle" ; oboInOwl:id "UBERON:0002033" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "arrector muscle of hair" ; rdfs:subClassOf obo:UBERON_0001135, [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002073 ], _:genid121859 . obo:UBERON_0002036 obo:IAO_0000115 "Muscle tissue that contains fibers that are divided by transverse bands into striations." ; obo:UBPROP_0000001 "Voluntary muscle tissue arranged in bundles of fibers.[AAO]" ; oboInOwl:hasDbXref "AAO:0010762", "AEO:0000140", "CALOHA:TS-2047", "EHDAA2:0003140", "EMAPA:36390", "FMA:67905", "MA:0002438", "NCIT:C12436", "UMLS:C1331262", "WBbt:0005779", "Wikipedia:Striated_muscle", "galen:StriatedMuscle" ; oboInOwl:hasExactSynonym "striated muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002036" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "striated muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000737 ] ) ] . obo:UBERON_0002037 obo:IAO_0000115 "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." ; obo:RO_0002161 obo:NCBITaxon_117565 ; obo:RO_0002171 obo:UBERON_0001893, obo:UBERON_0002298 ; obo:UBPROP_0000001 "Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO]", "Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG]" ; obo:UBPROP_0000007 "cerebellar" ; obo:UBPROP_0000008 "The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full]" ; obo:UBPROP_0000012 "almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem" ; oboInOwl:hasBroadSynonym "infratentorial region" ; oboInOwl:hasDbXref "AAO:0010485", "BAMS:CB", "BAMS:Cb", "BIRNLEX:1489", "BM:CB", "BTO:0000232", "CALOHA:TS-0125", "DHBA:10656", "EFO:0000327", "EHDAA2:0000232", "EMAPA:17787", "EV:0100293", "FMA:67944", "GAID:595", "HBA:4696", "MA:0000198", "MAT:0000110", "MBA:512", "MESH:D002531", "MIAA:0000110", "NCIT:C12445", "SCTID:180924008", "TAO:0000100", "UMLS:C0007765", "UMLS:C1268981", "VHOG:0000024", "Wikipedia:Cerebellum", "XAO:0003098", "ZFA:0000100", "neuronames:643" ; oboInOwl:hasExactSynonym "epencephalon-1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpus cerebelli", "parencephalon" ; oboInOwl:id "UBERON:0002037" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cerebellum" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:NBO_0000347 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001895 ], _:genid121881, _:genid121883, _:genid121885 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png"^^xsd:anyURI . obo:UBERON_0002038 obo:IAO_0000115 "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." ; obo:IAO_0000116 "TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA" ; obo:UBPROP_0000001 "Subdivision of the midbrain anterior to the midbrain tegmentum which contains darkly pigmented neurons[FMA][FMA:67947]." ; obo:UBPROP_0000003 "(...) the substantia nigra first appears in reptiles and is best developed in primates.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "SN" ; oboInOwl:hasDbXref "BAMS:SN", "BIRNLEX:789", "BTO:0000143", "CALOHA:TS-0990", "DHBA:12251", "EFO:0000922", "EHDAA2:0004711", "EMAPA:35835", "EV:0100247", "FMA:67947", "GAID:581", "HBA:9072", "MA:0000210", "MAT:0000504", "MESH:D013378", "NCIT:C12453", "SCTID:279286002", "UMLS:C0038590", "UMLS:C1269578", "VHOG:0001573", "Wikipedia:Substantia_nigra", "neuronames:536" ; oboInOwl:hasExactSynonym "Soemmering's substance", "nucleus of basis pedunculi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus pigmentosus subthalamo-peduncularis", "substancia nigra", "substantia nigra (Soemmerringi)" ; oboInOwl:id "UBERON:0002038" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "substantia nigra" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001891 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0010011 ], _:genid121904, _:genid121906, _:genid121908 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Midbraincrosssection.png"^^xsd:anyURI . obo:UBERON_0002040 obo:IAO_0000115 "A systemic artery that supplies the lung with with oxygenated blood." ; oboInOwl:hasDbXref "EMAPA:18608", "FMA:68109", "GAID:477", "MA:0001923", "MESH:D001981", "NCIT:C32230", "SCTID:244247009", "UMLS:C0006257", "Wikipedia:Bronchial_artery" ; oboInOwl:hasExactSynonym "bronchial arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriae bronchiales", "rami bronchiales partis thoracicae aortae" ; oboInOwl:id "UBERON:0002040" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:comment "Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung." ; rdfs:label "bronchial artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004848 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0012416 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004573 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004571 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png"^^xsd:anyURI . obo:UBERON_0002042 obo:IAO_0000115 "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." ; obo:UBPROP_0000001 "The vascular endothelium that lines the lymph vessels.[TAO]" ; oboInOwl:hasDbXref "BTO:0004303", "CALOHA:TS-2156", "EMAPA:35533", "FMA:68444", "MA:0000750", "MESH:D004729", "NCIT:C49258", "TAO:0005258", "UMLS:C1180786", "ZFA:0005258" ; oboInOwl:hasExactSynonym "endothelium of lymph vessel", "endothelium of lymphatic vessel", "lymph vessel endothelium", "lymphatic endothelium", "lymphatic vessel endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002042" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lymphatic vessel endothelium" ; rdfs:subClassOf obo:UBERON_0001986, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001473 ], _:genid121939 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:UBERON_0002046 obo:IAO_0000115 "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." ; obo:UBPROP_0000001 "Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]" ; obo:UBPROP_0000008 "In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes", "In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine)", "In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species" ; oboInOwl:hasDbXref "AAO:0010544", "BTO:0001379", "CALOHA:TS-1047", "EFO:0000861", "EHDAA2:0002028", "EHDAA:2148", "EHDAA:2975", "EMAPA:17068", "EV:0100133", "FMA:9603", "GAID:465", "MA:0000129", "MAT:0000081", "MESH:D013961", "MIAA:0000081", "NCIT:C12400", "SCTID:181117000", "UMLS:C0040132", "VHOG:0000418", "Wikipedia:Thyroid", "XAO:0000162", "galen:ThyroidGland" ; oboInOwl:hasExactSynonym "thyroid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandula thyroidea" ; oboInOwl:id "UBERON:0002046" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "thyroid gland" ; rdfs:subClassOf obo:UBERON_0002530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ], _:genid121226, [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0007689 ], _:genid121951, _:genid121953, _:genid121955 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg"^^xsd:anyURI . obo:UBERON_0002047 obo:IAO_0000115 "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." ; obo:RO_0002171 obo:UBERON_0002148, obo:UBERON_0002267, obo:UBERON_0002587, obo:UBERON_0003004 ; oboInOwl:hasDbXref "BAMS:PnR", "BAMS:RA-PONS", "BAMS:RPn", "BIRNLEX:1110", "DHBA:12471", "DHBA:12475", "FMA:68875", "HBA:9159", "MA:0001022", "MBA:238", "UMLS:C0175423", "Wikipedia:Pontine_raphe_nucleus", "neuronames:589" ; oboInOwl:hasExactSynonym "raphe of pons", "raphe pontis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus raphe pontis", "nucleus raphes pontis", "raphe (mediana pontina)", "raphe pontis nucleus" ; oboInOwl:id "UBERON:0002047" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pontine raphe nucleus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 ], _:genid121967 . obo:UBERON_0002048 obo:IAO_0000115 "Respiration organ that develops as an outpocketing of the esophagus." ; obo:UBPROP_0000001 "Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]" ; obo:UBPROP_0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]" ; obo:UBPROP_0000007 "pulmonary" ; obo:UBPROP_0000008 "respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi" ; oboInOwl:hasDbXref "AAO:0000275", "AAO:0010567", "BTO:0000763", "CALOHA:TS-0568", "EFO:0000934", "EHDAA2:0001042", "EHDAA:1554", "EHDAA:2205", "EMAPA:16728", "EV:0100042", "FMA:7195", "GAID:345", "MA:0000415", "MAT:0000135", "MESH:D008168", "MIAA:0000135", "NCIT:C12468", "SCTID:181216001", "UMLS:C0024109", "VHOG:0000310", "Wikipedia:Lung", "XAO:0000119", "galen:Lung" ; oboInOwl:hasExactSynonym "pulmo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002048" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]" ; rdfs:label "lung" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/701"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000171, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000170 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000118 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ], _:genid121980 . obo:UBERON_0002049 obo:IAO_0000115 "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." ; obo:IAO_0000116 "see also: vascular system. Consider merging?" ; obo:UBPROP_0000007 "vascular" ; oboInOwl:hasDbXref "BTO:0003718", "FMA:69050", "TAO:0005249", "ZFA:0005249" ; oboInOwl:hasExactSynonym "vascular network" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002049" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vasculature" ; rdfs:subClassOf obo:UBERON_0000477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007798 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000179 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000055 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg"^^xsd:anyURI . obo:UBERON_0002050 obo:IAO_0000115 "Anatomical structure that is part of an embryo." ; obo:UBPROP_0000001 "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO]", "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO]", "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO]" ; obo:UBPROP_0000012 "in FMA embryo is_a embryonic structure" ; oboInOwl:hasDbXref "AAO:0000138", "BILA:0000034", "BTO:0000174", "CALOHA:TS-2110", "EFO:0000461", "FBbt:00004208", "FMA:69067", "GAID:407", "MESH:D004628", "NCIT:C13229", "RETIRED_EHDAA2:0003169", "SCTID:667009", "TAO:0001105", "UMLS:C0013948", "VSAO:0000178", "XAO:0003042", "ZFA:0001105" ; oboInOwl:hasExactSynonym "developing embryonic structure", "embryonic anatomical structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "developing structure", "embryonale Struktur", "embryonic structures" ; oboInOwl:id "UBERON:0002050" ; oboInOwl:inSubset core:efo_slim, core:inconsistent_with_fma, core:vertebrate_core ; a owl:Class ; rdfs:label "embryonic structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:UBERON_0002051 obo:IAO_0000115 "An epithelium that is part of a bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001866", "CALOHA:TS-0570", "EMAPA:32693", "FMA:69077", "MA:0001772", "NCIT:C48942", "UMLS:C1181296" ; oboInOwl:hasExactSynonym "bronchiolar epithelium", "bronchiole epithelial tissue", "bronchiole epithelium", "epithelial tissue of bronchiole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002051" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of bronchiole" ; rdfs:subClassOf obo:UBERON_0000485, obo:UBERON_0004802, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005039 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002186 ], _:genid122017 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:UBERON_0002052 obo:IAO_0000115 "The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex." ; oboInOwl:hasDbXref "FMA:69087", "MA:0000117", "NCIT:C32050", "UMLS:C1181304" ; oboInOwl:hasExactSynonym "capsule of adrenal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal capsule" ; oboInOwl:id "UBERON:0002052" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "adrenal gland capsule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001235 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011822 ] ; owl:equivalentClass _:genid121295 . obo:UBERON_0002056 obo:IAO_0000115 "Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37088", "FMA:69264", "MA:0002056", "NCIT:C52737", "SCTID:303426004", "UMLS:C0226334", "Wikipedia:Inferior_suprarenal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria suprarenalis inferior" ; oboInOwl:id "UBERON:0002056" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "inferior suprarenal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005624 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001184 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png"^^xsd:anyURI . obo:UBERON_0002057 obo:IAO_0000115 "An artery that supplies the diaphragm." ; obo:UBPROP_0000008 "In humans this includes the superior and inferior phrenic arteries" ; oboInOwl:hasDbXref "EMAPA:37108", "FMA:69330", "MA:0002019", "NCIT:C33320", "UMLS:C1181536" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002057" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "phrenic artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004573 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] . obo:UBERON_0002058 obo:IAO_0000115 "A parasympathetic ganglion located in the posterior orbit that contains preganglionic nerves and postganglionic neurons of the oculomotor nerve, connects to the Edinger-Westphal nucleus via the oculomotor nerve and the eye muscles via the short ciliary nerve." ; obo:IAO_0000232 "the main ciliary ganglion (typically just called the ciliary ganglion) is differentiated from the accessory by connection to the oculomotor nerve." ; obo:UBPROP_0000001 "The ciliary ganglion is a parasympathetic ganglion located in the posterior orbit. It measures 1-2 millimeters in diameter and contains approximately 2,500 neurons. Preganglionic axons from the Edinger-Westphal nucleus form synapses with these cells. The postganglionic axons run in the short ciliary nerves and innervate two eye muscles: the sphincter pupillae constricts the pupil, known as Miosis. The opposite, Mydriasis, is the dilation of the pupil. the ciliaris muscle contracts, releasing tension on the Zonular Fibers, making the lens more convex, also known as accommodation. Both of these muscles are involuntary - they are controlled by the autonomic nervous system. It is one of four parasympathetic ganglia of the head and neck.. [WP,unvetted][Wikipedia:Ciliary_ganglion]." ; obo:UBPROP_0000003 "Little is known about the development of parasympathetic neurons apart from the ciliary ganglion in chicks. Although there are considerable gaps in our knowledge, some of the mechanisms controlling sympathetic and enteric neuron development appear to be conserved between mammals, avians and zebrafish.[uncertain][VHOG]" ; oboInOwl:hasDbXref "BAMS:GcIII", "EFO:0002559", "EHDAA2:0000251", "EHDAA:5623", "EMAPA:18222", "FMA:6964", "MA:0001136", "NLXANAT:100304", "SCTID:279281007", "VHOG:0000805", "Wikipedia:Ciliary_ganglion" ; oboInOwl:hasExactSynonym "ciliary ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ganglion ciliare" ; oboInOwl:id "UBERON:0002058" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "main ciliary ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ], _:genid122056 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001808 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001643 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0022302 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Augennerven.jpg"^^xsd:anyURI . obo:UBERON_0002059 obo:IAO_0000115 "The ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands." ; oboInOwl:hasDbXref "BTO:0001318", "EHDAA2:0001942", "EHDAA:6710", "EMAPA:36276", "FMA:6966", "MA:0002470", "NCIT:C52558", "SCTID:279282000", "UMLS:C0229063", "Wikipedia:Submandibular_ganglion" ; oboInOwl:hasExactSynonym "mandibular ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Blandin`s ganglion", "ganglion submandibulare", "lingual ganglion", "maxillary ganglion", "submaxillary ganglion" ; oboInOwl:id "UBERON:0002059" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "submandibular ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0003721 ], _:genid122067 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001736 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/83/Gray778.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/8/83/Gray778.png/200px-Gray778.png"^^xsd:anyURI . obo:UBERON_0002060 obo:IAO_0000115 "The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted]." ; obo:UBPROP_0000001 "Artery which supplies blood via branches to the hindlimbs.[AAO]" ; oboInOwl:hasDbXref "AAO:0010222", "BTO:0001624", "CALOHA:TS-0321", "EMAPA:35342", "FMA:70248", "GAID:494", "MA:0001951", "MESH:D005263", "NCIT:C12715", "SCTID:244332003", "UMLS:C0015801", "Wikipedia:Femoral_artery", "galen:FemoralArtery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria femoralis" ; oboInOwl:id "UBERON:0002060" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "femoral artery" ; rdfs:subClassOf obo:UBERON_0001637, _:genid122078 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray546.png"^^xsd:anyURI . obo:UBERON_0002061 obo:IAO_0000115 "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." ; obo:UBPROP_0000012 "assume spelling error for ncit" ; oboInOwl:hasDbXref "EHDAA2:0004143", "EMAPA:35887", "FMA:70301", "GAID:554", "MA:0000103", "MESH:D014338", "NCIT:C34317", "SCTID:308828009", "UMLS:C1519589", "Wikipedia:Truncus_arteriosus_(embryology)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002061" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "truncus arteriosus" ; rdfs:subClassOf obo:UBERON_0001637, obo:UBERON_0002050, _:genid122086, _:genid122088, _:genid122090 . obo:UBERON_0002062 obo:IAO_0000115 "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." ; obo:UBPROP_0000001 "Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]" ; obo:UBPROP_0000003 "(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000434", "EHDAA2:0004028", "EHDAA:2586", "EMAPA:16696", "FMA:70302", "MA:0000078", "MESH:D054089", "TAO:0001317", "VHOG:0000932", "Wikipedia:Atrioventricular_cushions", "XAO:0004189", "ZFA:0001317" ; oboInOwl:hasExactSynonym "AV cushion", "atrioventricular cushion", "cardiac cushion", "endocardial cushion tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrioventricular canal cushion", "endocardial cushions" ; oboInOwl:id "UBERON:0002062" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form" ; rdfs:label "endocardial cushion" ; rdfs:subClassOf obo:UBERON_0003104, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid122097, _:genid122099, _:genid122101 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png"^^xsd:anyURI . obo:UBERON_0002063 obo:IAO_0000115 "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." ; obo:UBPROP_0000001 "Heart region collecting blood from the paired common cardinal veins and delivering to the atrium. One of four components of the heart. The sinus venosus also acts as a pacemaker and is the first to contract. Kimmel et al, 1995.[TAO]", "Part of the circulatory system which receives blood from the systemic veins and contracts to pump the blood into the atrium of the heart.[AAO]" ; obo:UBPROP_0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" ; obo:UBPROP_0000008 "In fish, receives venous blood from the systemic circulation through paired hepatic veins, anterior jugular veins and Cuvierian ducts[PMID:20735616]", "In humans, it exists distinctly only in the embryonic heart, where it is found between the two venae cavae. In the adult, it is incorporated into the wall of the right atrium to form a smooth part called the sinus venarum, also known as the venarum sinus, which is separated from the rest of the atrium by a ridge of fibres called the crista terminalis. The sinus venosus also forms the SA node and the coronary sinus. In the embryo, the thin walls of the sinus venosus are connected below with the right ventricle, and medially with the left atrium, but are free in the rest of their extent. It receives blood from the vitelline vein, umbilical vein and common cardinal vein. It originally starts as a paired structure but shifts towards associating only with the right atrium as the embryonic heart develops. The left portion shrinks in size and eventually forms the coronary sinus and oblique vein of the left atrium, whereas the right part becomes incorporated into the right atrium to form the sinus venarmu", "In zebrafish, the sinus venosus also acts as a pacemaker and is the first to contract" ; oboInOwl:hasBroadSynonym "inflow tract" ; oboInOwl:hasDbXref "AAO:0010505", "EHDAA2:0001839", "EHDAA:480", "EMAPA:16237", "FMA:70303", "NCIT:C34299", "NCIT:C34300", "TAO:0000154", "UMLS:C0225857", "UMLS:C0231084", "VHOG:0000177", "Wikipedia:Sinus_venosus", "ZFA:0000154" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinus venarum", "sinus venosus cordis", "venarum", "venarum sinus", "venosus" ; oboInOwl:id "UBERON:0002063" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "sinus venosus" ; rdfs:subClassOf obo:UBERON_0004151, _:genid122112, _:genid122114 ; owl:disjointWith obo:UBERON_0006615 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png"^^xsd:anyURI . obo:UBERON_0002065 obo:IAO_0000115 "One of two paired cardinal veins that return blood from the body of the embryo[Kardong]." ; obo:UBPROP_0000001 "Continuation of the caudal vein cranial to the anal pore. The cardinal vein splits into a pair of vessels in the cranial trunk, just caudal to the radix of the aorta. The posterior cardinals each empty into the common cardinal vein. [TAO]", "Either of two veins which receive blood as an alternate route from the kidneys.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of axial vasculature (TAO:0001073)[TAO]", "relationship loss: part_of cardinal system (TAO:0000096)[TAO]" ; obo:UBPROP_0000003 "In primitive vertebrates, the basic early embryonic pattern is retained, and blood from anterior and posterior systemic tissues is returned in anterior and posterior cardinal veins, both pairs of veins uniting in common cardinal veins near the heart. In derived vertebrates, the cardinals appear but usually persist only in the embryo, being functionally replaced by alternative adult vessels, the precava and postcava (anterior and posterior venae cavae).[well established][VHOG]" ; obo:UBPROP_0000011 "join with the corresponding right and left cardinal veins to form the left common cardinal veins, which empty in the sinus venosus. Most of the posterior cardinal veins regress, what remains of them forms the renal segment of the inferior vena cava and the common iliac veins. Later in the development stages, the posterior cardinal veins are replaced by the subcardinal and supracardinal veins. The subcardinal veins form part of the inferior vena cava, renal veins and gonadal veins. The supracardinal veins form part of the inferior vena cava, the intercostal veins, hemiazygos vein and azygos vein" ; oboInOwl:hasDbXref "AAO:0010511", "BTO:0004386", "EHDAA2:0001486", "EHDAA:1316", "EMAPA:16357", "FMA:70314", "NCIT:C34257", "SCTID:308781005", "TAO:0000477", "UMLS:C0231087", "VHOG:0000111", "Wikipedia:Posterior_cardinal_vein", "XAO:0000241", "ZFA:0000477" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PCV", "axial vein", "caudal cardinal veins", "inferior cardinal vein", "postcardinal vein" ; oboInOwl:id "UBERON:0002065" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "posterior cardinal vein" ; rdfs:subClassOf obo:UBERON_0004344, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002201 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0002201 ] . obo:UBERON_0002067 obo:IAO_0000115 "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." ; obo:IAO_0000116 "Consider adding a layer-of-skin grouping class for all skin layers" ; obo:UBPROP_0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" ; obo:UBPROP_0000003 "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" ; obo:UBPROP_0000007 "dermal" ; oboInOwl:hasDbXref "AAO:0000128", "BTO:0000294", "CALOHA:TS-2076", "EFO:0000953", "EMAPA:17527", "EV:0100154", "FMA:70323", "GAID:1321", "MA:0000152", "MAT:0000153", "MESH:D020405", "MIAA:0000153", "NCIT:C12701", "SCTID:361696001", "TAO:0001119", "UMLS:C0011646", "VHOG:0000108", "Wikipedia:Dermis", "XAO:0000217", "ZFA:0001119" ; oboInOwl:hasExactSynonym "vertebrate dermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corium", "cutis" ; oboInOwl:id "UBERON:0002067" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dermis" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0011860 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000107 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0002072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ], _:genid122142, _:genid122148, _:genid122151 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg"^^xsd:anyURI . obo:UBERON_0002068 obo:IAO_0000115 "A fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies[MP]." ; obo:UBPROP_0000001 "A fetal canal connecting the bladder with the allantois, persisting throughout life as a cord (median umbilical ligament). [TFD][VHOG]" ; obo:UBPROP_0000007 "urachal" ; oboInOwl:hasDbXref "EHDAA2:0002137", "EHDAA:7016", "EHDAA:9332", "EMAPA:18323", "FMA:70343", "GAID:1313", "MA:0001701", "MESH:D014497", "NCIT:C12338", "RETIRED_EHDAA2:0002138", "SCTID:276858000", "UMLS:C0041916", "VHOG:0000735", "Wikipedia:Urachus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002068" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "urachus" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0007118 ], _:genid122160, _:genid122163 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png"^^xsd:anyURI . obo:UBERON_0002069 obo:IAO_0000115 "The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis." ; oboInOwl:hasDbXref "BTO:0000361", "EMAPA:32786", "FMA:70344", "MA:0000805", "NCIT:C33627", "SCTID:418563001", "UMLS:C0221923", "Wikipedia:Stratum_granulosum" ; oboInOwl:hasExactSynonym "epidermis stratum granulosum", "granular layer of epidermis", "stratum granulosum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epidermis granular layer" ; oboInOwl:id "UBERON:0002069" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "stratum granulosum of epidermis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0015014 ; owl:someValuesFrom obo:UBERON_0002026 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013754 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000712 ] ) ] . obo:UBERON_0002072 obo:IAO_0000115 "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." ; obo:UBPROP_0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]", "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]." ; obo:UBPROP_0000007 "hypodermal", "subcutaneous", "subcutaneus" ; obo:UBPROP_0000012 "BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument." ; oboInOwl:hasDbXref "BTO:0001314", "CALOHA:TS-2366", "EMAPA:37505", "FMA:70544", "NCIT:C33645", "TAO:0001136", "UMLS:C0278403", "Wikipedia:Hypodermis", "ZFA:0001136" ; oboInOwl:hasExactSynonym "hypoderm", "vertebrate hypodermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sub-tegumental tissue", "subcutaneous tissue", "subcutis", "subtegumental tissue", "superficial fascia", "tela subcutanea" ; oboInOwl:id "UBERON:0002072" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hypodermis" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000107 ; owl:someValuesFrom obo:UBERON_0002067 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0001015 ], _:genid121434, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001013 ], _:genid122179, _:genid122185 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg"^^xsd:anyURI . obo:UBERON_0002073 obo:IAO_0000115 "A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." ; obo:UBPROP_0000003 "The earliest reliable record of hair is found in a fossil of the Paleocene period, in which the structure of hair cuticles is preserved. Its appearance suggests that the complicated structure of the hair follicle, closely similar to that of present-day mammals, had already appeared at this time.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0000554", "CALOHA:TS-0432", "EFO:0002464", "EMAPA:18771", "EMAPA:29741", "EV:0100156", "FMA:70660", "GAID:934", "MA:0000154", "MESH:D018859", "NCIT:C13317", "SCTID:280830006", "UMLS:C0221971", "VHOG:0001268", "Wikipedia:Hair_follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "folliculus pili" ; oboInOwl:id "UBERON:0002073" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Development notes:Formation largely takes place during fetal and perinatal skin development. However, after skin wounding de novo hair follicle formation may also occur in adult mouse and rabbit skin[DOI:10.1016/j.cub.2008.12.005]." ; rdfs:label "hair follicle" ; rdfs:subClassOf obo:UBERON_0036150, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005086 ], _:genid122198, _:genid122200 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg"^^xsd:anyURI . obo:UBERON_0002074 obo:IAO_0000115 "The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla." ; obo:IAO_0000116 "TODO - add distinct subclasses for coat hair vs vibrissa hair", "TODO - check definition of trichocyte in CL" ; oboInOwl:hasDbXref "BTO:0004672", "EMAPA:36498", "FMA:70728", "MA:0000159", "NCIT:C33543", "SCTID:361359004", "UMLS:C0221961" ; oboInOwl:hasExactSynonym "shaft of hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "scapus pili" ; oboInOwl:id "UBERON:0002074" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hair shaft" ; rdfs:subClassOf obo:UBERON_0000021, _:genid122208 . obo:UBERON_0002075 obo:IAO_0000115 "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." ; obo:UBPROP_0000001 "An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO]" ; obo:UBPROP_0000012 "general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs." ; oboInOwl:hasDbXref "AAO:0010386", "BTO:0001491", "EHDAA:512", "EMAPA:16245", "FMA:7085", "MA:0000019", "MESH:D014781", "NCIT:C28287", "RETIRED_EHDAA2:0002201", "SCTID:118760003", "UMLS:C0042779", "Wikipedia:Viscus", "XAO:0003034" ; oboInOwl:hasExactSynonym "visceral organ", "visceral organ system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "splanchnic tissue", "viscera", "visceral tissue" ; oboInOwl:id "UBERON:0002075" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim, core:upper_level ; a owl:Class ; rdfs:label "viscus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ] ) ] . obo:UBERON_0002076 obo:IAO_0000115 "Smooth and glossy outer protective cell layer of hair shaft." ; oboInOwl:hasDbXref "EMAPA:35388", "FMA:70933", "MA:0000157" ; oboInOwl:hasExactSynonym "hair cuticle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002076" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cuticle of hair" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002074 ] ) ] . obo:UBERON_0002077 obo:IAO_0000115 "A cortex that is part of a hair [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35387", "FMA:70934", "MA:0000156", "SCTID:318832008" ; oboInOwl:hasExactSynonym "coat hair cortex", "coat/hair cortex", "cortex of coat hair", "cortex of coat/hair", "hair cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002077" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cortex of hair" ; rdfs:subClassOf obo:UBERON_0001851, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] . obo:UBERON_0002078 obo:IAO_0000115 "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." ; obo:UBPROP_0000001 "Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA]" ; obo:UBPROP_0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "AAO:0010248", "BTO:0001703", "EHDAA2:0000290", "EMAPA:17321", "FMA:7096", "MA:0000075", "NCIT:C12868", "SCTID:244383003", "UMLS:C0225844", "VHOG:0000328", "Wikipedia:Right_atrium", "XAO:0003192", "galen:RightAtrium" ; oboInOwl:hasExactSynonym "cardiac right atrium", "heart right atrium", "right atrium", "right atrium of heart", "right cardiac atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrium dextrum" ; oboInOwl:id "UBERON:0002078" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "right cardiac atrium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0004537 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002081 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002079 obo:IAO_0000115 "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." ; obo:UBPROP_0000001 "Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA]", "The chamber of the heart that receives blood from the lungs[XAO:EJS]." ; obo:UBPROP_0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "AAO:0010247", "BTO:0001702", "EHDAA2:0000275", "EMAPA:17315", "FMA:7097", "MA:0000074", "NCIT:C12869", "SCTID:244387002", "UMLS:C0225860", "VHOG:0000369", "Wikipedia:Left_atrium", "XAO:0003191", "galen:LeftAtrium" ; oboInOwl:hasExactSynonym "atrium sinistrum", "cardiac left atrium", "heart left atrium", "left atrium", "left atrium of heart", "left cardiac atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002079" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "left cardiac atrium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0004537 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002081 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002080 obo:IAO_0000115 "A cardiac ventricle that is in the right side of the heart." ; obo:UBPROP_0000001 "The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In mammals continuous with the pulmonary arteries" ; oboInOwl:hasDbXref "BTO:0001630", "CALOHA:TS-0443", "EHDAA2:0000196", "EMAPA:17340", "FMA:7098", "MA:0000093", "NCIT:C12870", "SCTID:244384009", "UMLS:C0225883", "VHOG:0000717", "Wikipedia:Right_ventricle", "galen:RightVentricle" ; oboInOwl:hasExactSynonym "cardiac right ventricle", "right ventricle", "right ventricle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right cardiac ventricle", "ventriculus dexter" ; oboInOwl:id "UBERON:0002080" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "heart right ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0004537 ], _:genid122272, _:genid122274 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002082 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002081 obo:IAO_0000115 "Cardiac chamber in which blood enters the heart." ; obo:UBPROP_0000001 "One of four heart chambers.[TAO]", "One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO]" ; obo:UBPROP_0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010246", "BTO:0000903", "CALOHA:TS-0437", "EFO:0000277", "EHDAA2:0000154", "EHDAA:1265", "EMAPA:16688", "EV:0100019", "FMA:7099", "GAID:555", "MA:0000073", "MAT:0000496", "MESH:D006325", "NCIT:C12728", "SCTID:261405004", "TAO:0000471", "UMLS:C0018792", "VHOG:0000175", "Wikipedia:Heart_atrium", "ZFA:0000471", "galen:Atrium" ; oboInOwl:hasExactSynonym "atria", "atrium", "atrium of heart", "cardiac atria", "heart atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrial tissue" ; oboInOwl:id "UBERON:0002081" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cardiac atrium" ; rdfs:subClassOf obo:UBERON_0004151, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010227 ] . obo:UBERON_0002082 obo:IAO_0000115 "Cardiac chamber through which blood leaves the heart." ; obo:UBPROP_0000001 "A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO]", "One of four heart chambers.[TAO]" ; obo:UBPROP_0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG]" ; oboInOwl:hasBroadSynonym "ventricle" ; oboInOwl:hasDbXref "AAO:0010249", "BTO:0000862", "CALOHA:TS-0444", "EFO:0000317", "EHDAA2:0004164", "EHDAA:1912", "EMAPA:17331", "EV:0100020", "FMA:7100", "GAID:568", "MA:0000091", "MAT:0000497", "MESH:D006352", "NCIT:C12730", "SCTID:277699000", "TAO:0000009", "UMLS:C0018827", "VHOG:0000435", "Wikipedia:Ventricle_(heart)", "XAO:0003193", "ZFA:0000009", "galen:Ventricle" ; oboInOwl:hasExactSynonym "heart ventricle", "lower chamber of heart", "ventricle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002082" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cardiac ventricle" ; rdfs:subClassOf obo:UBERON_0004151, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ], _:genid122294 . obo:UBERON_0002084 obo:IAO_0000115 "A cardiac ventricle that is in the left side of the heart." ; obo:UBPROP_0000001 "Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In mammals continuous with aorta" ; oboInOwl:hasDbXref "BTO:0001629", "CALOHA:TS-0439", "EHDAA2:0002178", "EMAPA:17337", "FMA:7101", "MA:0000092", "NCIT:C12871", "SCTID:244385005", "UMLS:C0225897", "VHOG:0000718", "Wikipedia:Left_ventricle", "galen:LeftVentricle" ; oboInOwl:hasExactSynonym "cardiac left ventricle", "left cardiac ventricle", "left ventricle", "left ventricle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventriculus sinister cordis" ; oboInOwl:id "UBERON:0002084" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "heart left ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000947 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0004537 ], _:genid122307 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002082 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002085 obo:IAO_0000115 "A cardiac septum that divides the left and right atria of the heart." ; obo:UBPROP_0000001 "The partition separating the right and left atria of the heart. [TFD][VHOG]" ; obo:UBPROP_0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000838", "EHDAA:1896", "EMAPA:17011", "FMA:7108", "MA:0000084", "NCIT:C32818", "SCTID:362016003", "UMLS:C0225836", "VHOG:0000385", "Wikipedia:Interatrial_septum", "galen:InteratrialSeptum" ; oboInOwl:hasExactSynonym "atrial septum", "atrium septum", "interatrial septal wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002085" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "interatrial septum" ; owl:equivalentClass _:genid121560 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png"^^xsd:anyURI . obo:UBERON_0002087 obo:IAO_0000115 "The part of the heart connecting the atrium to the cardiac ventricle[ZFA]. In the developing heart, the constriction between the atrium and ventricle constitutes the atrial canal, and indicates the site of the future atrioventricular valves[WP]." ; obo:UBPROP_0000001 "The canal connecting the primitive atrium and ventricle in fishes and amniotes embryo. [TFD][VHOG]" ; obo:UBPROP_0000003 "The heart is the first organ to form and function in a vertebrate. (...) Septation of the AV canal is initiated with the formation of inferior and superior endocardial cushions in response to signaling from the overlying myocardium. (...) Analysis of zebrafish mutants with cardiovascular defects uncovered a previously unexpected level of conservation between zebrafish and human cardiovascular physiology.[uncertain][VHOG]" ; obo:UBPROP_0000009 "In the embryo, the atrioventricular canal delays the impulse from atrium to ventricle[PMID:22984480]" ; obo:UBPROP_0000011 "The right side of the AVC becomes the tricuspid valve whereas the left side of the AVC will become the bicuspid valve" ; obo:UBPROP_0000012 "this is a lumen in EHDAA2" ; oboInOwl:hasDbXref "EHDAA:764", "EMAPA:16546", "FMA:71121", "SCTID:341079007", "TAO:0001315", "VHOG:0001473", "Wikipedia:Atrioventricular_canal", "XAO:0004123", "ZFA:0001315" ; oboInOwl:hasExactSynonym "AV canal", "AVC", "atrial canal", "atrio-ventricular canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis atrioventricularis", "ependymal canal" ; oboInOwl:id "UBERON:0002087" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "atrioventricular canal" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002082 ], _:genid122325, _:genid122329 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d8/Gray464.png"^^xsd:anyURI . obo:UBERON_0002089 obo:IAO_0000115 "Companion vein of the thoracodorsal artery, draining the apical part of the latissimus dorsi and merging with the circumflex scapular vein to form a subscapular vein." ; oboInOwl:hasDbXref "EMAPA:37198", "FMA:71213", "MA:0002238" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002089" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracodorsal vein" ; rdfs:subClassOf _:genid122344 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001112 ] ) ] . obo:UBERON_0002090 obo:IAO_0000115 "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." ; obo:UBPROP_0000001 "Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO]", "The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO]", "The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO]" ; obo:UBPROP_0000003 "The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "axial skeleton" ; oboInOwl:hasDbXref "AAO:0000034", "EFO:0000942", "EHDAA2:0000161", "EHDAA:5049", "EMAPA:17214", "EMAPA:37721", "FMA:71221", "MA:0002986", "MAT:0000148", "MIAA:0000148", "TAO:0000317", "VHOG:0000317", "VSAO:0000093", "XAO:0003073", "ZFA:0000317" ; oboInOwl:hasExactSynonym "post-cranial axial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002090" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed." ; rdfs:label "postcranial axial skeleton" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005944 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011138 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 ] . obo:UBERON_0002091 obo:IAO_0000115 "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." ; obo:UBPROP_0000001 "Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO]", "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]", "The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO]" ; obo:UBPROP_0000012 "ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved." ; oboInOwl:hasDbXref "AAO:0000747", "EFO:0000951", "EMAPA:32729", "FMA:71222", "MA:0000290", "MAT:0000278", "MIAA:0000278", "NCIT:C49477", "SCTID:322050006", "UMLS:C0222646", "VHOG:0001666", "VSAO:0000076", "Wikipedia:Appendicular_skeleton", "XAO:0003166" ; oboInOwl:hasExactSynonym "appendicular skeleton", "entire appendicular skeleton" ; oboInOwl:hasNarrowSynonym "paired fin skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeleton appendiculare" ; oboInOwl:id "UBERON:0002091" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "appendicular skeleton" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011249 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000026 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001434 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg"^^xsd:anyURI . obo:UBERON_0002092 obo:IAO_0000115 "The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer." ; obo:UBPROP_0000001 "The outermost and densest membrane of the three mammalian meninges covering the brain and spinal cord. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:32668", "EV:0100313", "FMA:71236", "MA:0000815", "NCIT:C49332", "SCTID:309321003", "UMLS:C0459393", "VHOG:0000270" ; oboInOwl:hasExactSynonym "cranial dura mater", "dura mater cranialis", "dura mater encephali", "dura mater of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002092" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain dura mater" ; rdfs:subClassOf obo:UBERON_0002363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0002093 obo:IAO_0000115 "A dura mater that is part of a spinal cord [Automatically generated definition]." ; obo:UBPROP_0000001 "The outermost and densest membrane of the three mammalian meninges covering the brain and spinal cord. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17806", "FMA:71237", "MA:0001132", "NCIT:C49799", "SCTID:362302001", "UMLS:C0228124", "VHOG:0000411" ; oboInOwl:hasExactSynonym "dura mater of neuraxis of spinal cord", "dura mater of spinal cord", "spinal cord dura mater", "spinal cord dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002093" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "spinal dura mater" ; rdfs:subClassOf obo:UBERON_0002363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0002094 obo:IAO_0000115 "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." ; obo:UBPROP_0000001 "The partition separating the right and left ventricles of the heart. [TFD][VHOG]" ; obo:UBPROP_0000003 "The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG]" ; obo:UBPROP_0000011 "involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999)" ; oboInOwl:hasDbXref "BTO:0002483", "EFO:0001956", "EHDAA:2603", "EMAPA:17333", "FMA:7133", "MA:0000085", "NCIT:C32874", "SCTID:362019005", "UMLS:C0225870", "VHOG:0000386", "Wikipedia:Interventricular_septum", "galen:InterventricularSeptum" ; oboInOwl:hasExactSynonym "heart interventricular septum", "heart ventricular septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interventricular septum of heart", "interventriculare cordis", "intraventricular septum", "s. interventriculare cordis", "septum inferius", "septum membranaceum", "ventricle septum", "ventricular septum" ; oboInOwl:id "UBERON:0002094" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "interventricular septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002099 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002080 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png"^^xsd:anyURI . obo:UBERON_0002095 obo:IAO_0000115 "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." ; obo:UBPROP_0000007 "mesenteric" ; obo:UBPROP_0000012 "in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery." ; oboInOwl:hasDbXref "AAO:0011061", "BTO:0001380", "EV:0100083", "FMA:7144", "GAID:21", "MESH:D008643", "NCIT:C33103", "SCTID:362707009", "UMLS:C0025474", "Wikipedia:Mesentery#Mesentery_.28general.29", "galen:Mesentery" ; oboInOwl:hasExactSynonym "generic mesentery", "mesentery (generic)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002095" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesentery" ; rdfs:subClassOf obo:UBERON_0000042 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png"^^xsd:anyURI . obo:UBERON_0002097 obo:IAO_0000115 "The organ covering the body that consists of the dermis and epidermis." ; obo:IAO_0000232 "consider 'integumentary system' for invertebrates" ; obo:UBPROP_0000012 "MA uses the term skin to refer to what is called here: zone of skin" ; oboInOwl:hasDbXref "BTO:0001253", "CALOHA:TS-0934", "EFO:0000962", "EHDAA2:0001844", "EMAPA:17525", "FMA:7163", "MESH:D012867", "MFMO:0000099", "NCIT:C12470", "SCTID:181469002", "UMLS:C1123023", "Wikipedia:Skin", "XAO:0000023", "galen:Skin" ; oboInOwl:hasExactSynonym "entire skin", "skin organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "entire integument", "integument", "integumental organ", "pelt", "skin" ; oboInOwl:id "UBERON:0002097" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "skin of body" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000014 ], _:genid122416 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg"^^xsd:anyURI . obo:UBERON_0002099 obo:IAO_0000115 "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." ; obo:UBPROP_0000008 "'Terrestrial vertebrates have divided hearts in which septae separate the oxygenated and deoxygenated blood within the pulmonary and systemic circulations'" ; obo:UBPROP_0000012 "in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this" ; oboInOwl:hasDbXref "EMAPA:35400", "FMA:7180", "GAID:562", "MA:0000083", "MESH:D006346", "NCIT:C49485", "SCTID:362014000", "UMLS:C0018819" ; oboInOwl:hasExactSynonym "cardiac septa", "heart septa", "heart septum", "septum of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spiral septa" ; oboInOwl:id "UBERON:0002099" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cardiac septum" ; rdfs:subClassOf obo:UBERON_0003037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004151 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0002100 obo:IAO_0000115 "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." ; obo:RO_0002171 obo:UBERON_0000026, obo:UBERON_0000033 ; obo:UBPROP_0000001 "Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]", "Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]" ; oboInOwl:hasDbXref "AAO:0010339", "BILA:0000116", "BTO:0001493", "CALOHA:TS-1071", "EFO:0000966", "EMAPA:31857", "FMA:7181", "MA:0000004", "MAT:0000296", "MIAA:0000296", "NCIT:C33816", "SCTID:262225004", "TAO:0001115", "UMLS:C0460005", "Wikipedia:Torso", "XAO:0000054", "XAO:0003025", "ZFA:0001115", "galen:Trunk" ; oboInOwl:hasExactSynonym "thoracolumbar region", "torso", "trunk region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Rumpf" ; oboInOwl:id "UBERON:0002100" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trunk" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013702 ] ; owl:disjointWith obo:UBERON_0002464 . obo:UBERON_0002101 obo:IAO_0000115 "A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts." ; obo:UBPROP_0000001 "Organism subdivision that has as its parts the jointed appendages used for locomotion and manipulation.[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010336", "AEO:0000172", "CALOHA:TS-0552", "EFO:0000876", "EHDAA2:0003172", "EHDAA:1697", "EHDAA:8273", "EMAPA:16405", "FMA:24875", "GAID:36", "MA:0000007", "MAT:0000090", "MIAA:0000090", "NCIT:C12429", "SCTID:243996003", "UMLS:C0015385", "VHOG:0000336", "VSAO:0000121", "Wikipedia:Limb", "XAO:0003027", "galen:Extremity" ; oboInOwl:hasExactSynonym "free limb", "limb sensu Vertebrata", "pentadactyl limb", "tetrapod limb" ; oboInOwl:hasNarrowSynonym "flipper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extremities", "extremity" ; oboInOwl:id "UBERON:0002101" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "limb" ; rdfs:subClassOf obo:UBERON_0004708, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004347 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0004381 ] ) ] . obo:UBERON_0002102 obo:IAO_0000115 "A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." ; obo:IAO_0000232 "Note distinction between arm and forelimb. hand is part of forelimb, but not part of arm" ; obo:RO_0002171 obo:UBERON_0002103 ; obo:UBPROP_0000001 "Upper limb, which connects the manus with the pectoral girdle.[AAO]" ; obo:UBPROP_0000012 "note that this corresponds to FMA:'free upper limb' (a limb segment), NOT FMA:'upper limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb" ; oboInOwl:hasDbXref "AAO:0000205", "BTO:0001729", "CALOHA:TS-2214", "EFO:0000882", "EHDAA2:0002133", "EHDAA:6208", "EMAPA:17412", "EV:0100014", "FMA:24878", "GAID:1215", "GAID:51", "MA:0000025", "MAT:0000394", "MESH:D005552", "MIAA:0000394", "NCIT:C12671", "SCTID:182245002", "UMLS:C1140618", "VHOG:0000338", "VSAO:0000148", "Wikipedia:Forelimb", "XAO:0003030", "galen:UpperExtremity" ; oboInOwl:hasExactSynonym "anteriormost limb", "fore limb", "forelimb", "free part of upper limb", "free upper limb", "membrum superius", "pectoral limb", "superior member", "upper extremity", "upper limb" ; oboInOwl:hasNarrowSynonym "pectoral flipper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foreleg" ; oboInOwl:id "UBERON:0002102" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "forelimb" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001421 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005417 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_0002103 obo:IAO_0000115 "A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts." ; obo:UBPROP_0000001 "Lower limb, which connects the pes with the pelvic girdle.[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000007 "crural" ; obo:UBPROP_0000012 "note that this corresponds to FMA:'free lower limb' (a limb segment), NOT 'lower limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb. Note that AAO class probably refers to skeleton" ; oboInOwl:hasDbXref "AAO:0000219", "BTO:0002345", "CALOHA:TS-2215", "EFO:0000883", "EHDAA2:0001033", "EHDAA:6094", "EMAPA:17458", "EV:0100015", "FMA:24879", "GAID:1221", "GAID:38", "MA:0000026", "MAT:0000395", "MESH:D006614", "MIAA:0000395", "NCIT:C12742", "NCIT:C77625", "SCTID:182281004", "UMLS:C0023216", "UMLS:C1522391", "VHOG:0000337", "VSAO:0000150", "Wikipedia:Hindlimb", "XAO:0003031", "galen:LowerExtremity" ; oboInOwl:hasExactSynonym "free lower limb", "hind limb", "hind-limb", "hindlimb", "inferior member", "lower limb", "membrum inferius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "free part of lower limb", "lower extremity", "membrum inferius", "pelvic appendage" ; oboInOwl:id "UBERON:0002103" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hindlimb" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000154 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001271 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005418 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002101 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray1239.png"^^xsd:anyURI . obo:UBERON_0002104 obo:IAO_0000115 "The sensory system subserving the sense of vision." ; obo:UBPROP_0000001 "The sensory system used for sight.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0007036" ; oboInOwl:hasDbXref "AAO:0000632", "BILA:0000140", "EMAPA:36003", "FMA:7191", "MA:0002444", "NCIT:C12888", "SCTID:281831001", "TAO:0001127", "UMLS:C0587900", "Wikipedia:Visual_system", "XAO:0003198", "ZFA:0001127", "http://uri.neuinfo.org/nif/nifstd/FMAID_7191" ; oboInOwl:hasExactSynonym "photosensory system", "visual organ system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002104" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "visual system" ; rdfs:subClassOf obo:UBERON_0001032, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007601 ] . obo:UBERON_0002105 obo:IAO_0000115 "Sensory system responsible for the perception of spatial orientation and auditory stimuli." ; obo:UBPROP_0000001 "The sensory system used for balance and hearing.[AAO]" ; oboInOwl:hasDbXref "AAO:0000631", "EMAPA:36002", "EMAPA:37985", "FMA:78500", "TAO:0001138", "XAO:0003195", "ZFA:0001138" ; oboInOwl:hasExactSynonym "auditory organ system", "vestibuloauditory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory system", "auditory/vestibular system", "vestibuloauditory system" ; oboInOwl:id "UBERON:0002105" ; oboInOwl:inSubset core:functional_classification, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vestibulo-auditory system" ; rdfs:subClassOf obo:UBERON_0001032, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007605 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg"^^xsd:anyURI . obo:UBERON_0002106 obo:IAO_0000115 "The organ that functions to filter blood and to store red corpuscles and platelets." ; obo:UBPROP_0000001 "An organ involved in red blood cell filtration and immune response.[AAO]" ; obo:UBPROP_0000003 "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "lienal", "splenic" ; obo:UBPROP_0000008 "In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron", "Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)" ; obo:UBPROP_0000009 "It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells" ; oboInOwl:hasDbXref "AAO:0010395", "BTO:0001281", "CALOHA:TS-0956", "EFO:0000869", "EMAPA:18767", "EV:0100055", "FMA:7196", "GAID:1289", "MA:0000141", "MAT:0000085", "MESH:D013154", "MIAA:0000085", "NCIT:C12432", "SCTID:181279003", "TAO:0000436", "UMLS:C0037993", "VHOG:0000120", "Wikipedia:Spleen", "XAO:0000328", "ZFA:0000436", "galen:Spleen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lien" ; oboInOwl:id "UBERON:0002106" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "spleen" ; rdfs:subClassOf obo:UBERON_0002075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006293 ], _:genid122505 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg"^^xsd:anyURI . obo:UBERON_0002107 obo:IAO_0000115 "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." ; obo:UBPROP_0000001 "Organ which secretes bile and participates in formation of certain blood proteins.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" ; obo:UBPROP_0000003 "All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]" ; obo:UBPROP_0000007 "hepatic" ; obo:UBPROP_0000008 "An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).", "The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates." ; obo:UBPROP_0000009 "secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." ; obo:UBPROP_0000012 "Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function." ; oboInOwl:hasDbXref "AAO:0010111", "BTO:0000759", "CALOHA:TS-0564", "EFO:0000887", "EHDAA2:0000997", "EHDAA:2197", "EMAPA:16846", "EV:0100089", "FMA:7197", "GAID:288", "MA:0000358", "MAT:0000097", "MESH:D008099", "MIAA:0000097", "NCIT:C12392", "SCTID:181268008", "TAO:0000123", "UMLS:C0023884", "VHOG:0000257", "Wikipedia:Liver", "XAO:0000133", "ZFA:0000123", "galen:Liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "iecur", "jecur" ; oboInOwl:id "UBERON:0002107" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "liver" ; rdfs:subClassOf obo:UBERON_0002365, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004647 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002423 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001970 ], [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0002384 ], [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0005978 ], [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0005980 ], _:genid122517, _:genid122519, _:genid122521, _:genid122523, _:genid122525, _:genid122528, _:genid122530, _:genid122532, _:genid122534 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg"^^xsd:anyURI . obo:UBERON_0002108 obo:IAO_0000115 "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." ; obo:UBPROP_0000001 "The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]" ; obo:UBPROP_0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010397", "BTO:0000651", "CALOHA:TS-0942", "EFO:0000841", "EMAPA:32834", "EV:0100072", "FMA:7200", "GAID:313", "MA:0000337", "MAT:0000047", "MESH:D007421", "MIAA:0000047", "NCIT:C12386", "SCTID:181250005", "TAO:0001323", "UMLS:C0021852", "VHOG:0000055", "Wikipedia:Small_intestine", "XAO:0000130", "ZFA:0001323", "galen:SmallIntestine" ; oboInOwl:hasExactSynonym "small bowel", "small intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior intestine", "intestinum tenue", "mid intestine" ; oboInOwl:id "UBERON:0002108" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "small intestine" ; rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000160 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg"^^xsd:anyURI . obo:UBERON_0002109 obo:IAO_0000115 "Pair of nostrils." ; obo:UBPROP_0000012 "this is a 'set of anatomical planes' in FMA" ; oboInOwl:hasDbXref "FMA:72005", "Wikipedia:Nares" ; oboInOwl:hasExactSynonym "nares set", "nostrils", "pair of nostrils" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nares", "set of nares" ; oboInOwl:id "UBERON:0002109" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "pair of nares" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000003 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid121789 ] . obo:UBERON_0002110 obo:IAO_0000115 "An organ that aids digestion and stores bile produced by the liver[WP]." ; obo:RO_0002161 obo:NCBITaxon_8801, obo:NCBITaxon_8930 ; obo:UBPROP_0000001 "Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]", "Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" ; obo:UBPROP_0000003 "The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010114", "BTO:0000493", "CALOHA:TS-0394", "EFO:0000853", "EHDAA2:0000699", "EHDAA:8062", "EMAPA:17202", "EV:0100090", "FMA:7202", "MA:0000356", "MAT:0000072", "MESH:D005704", "MIAA:0000072", "NCIT:C12377", "SCTID:181269000", "TAO:0000208", "UMLS:C0016976", "VHOG:0000221", "Wikipedia:Gallbladder", "XAO:0000135", "ZFA:0000208", "galen:Gallbladder" ; oboInOwl:hasExactSynonym "cholecyst", "gall bladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vesica biliaris", "vesica fellea" ; oboInOwl:id "UBERON:0002110" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)" ; rdfs:label "gallbladder" ; rdfs:subClassOf obo:UBERON_0018707, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004912 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001173 ], _:genid122569, _:genid122573 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg"^^xsd:anyURI . obo:UBERON_0002111 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0000087", "CALOHA:TS-1198", "EMAPA:36285", "FMA:72024", "MA:0000708", "NCIT:C49195", "UMLS:C1706851" ; oboInOwl:hasExactSynonym "arterial smooth muscle", "artery smooth muscle", "artery smooth muscle tissue", "smooth muscle of artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arterial smooth muscle cell" ; oboInOwl:id "UBERON:0002111" ; a owl:Class ; rdfs:label "artery smooth muscle tissue" ; rdfs:subClassOf obo:UBERON_0001135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0002112 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35323", "FMA:72025", "MA:0001573" ; oboInOwl:hasExactSynonym "esophageal smooth muscle", "esophagus involuntary muscle", "esophagus non-striated muscle", "esophagus smooth muscle", "esophagus smooth muscle tissue", "gullet involuntary muscle", "gullet non-striated muscle", "gullet smooth muscle", "gullet smooth muscle tissue", "involuntary muscle of esophagus", "involuntary muscle of gullet", "involuntary muscle of oesophagus", "non-striated muscle of esophagus", "non-striated muscle of gullet", "non-striated muscle of oesophagus", "oesophagus involuntary muscle", "oesophagus non-striated muscle", "oesophagus smooth muscle tissue", "smooth muscle of gullet", "smooth muscle of oesophagus", "smooth muscle tissue of esophagus", "smooth muscle tissue of gullet", "smooth muscle tissue of oesophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oesophagus smooth muscle" ; oboInOwl:id "UBERON:0002112" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "smooth muscle of esophagus" ; rdfs:subClassOf obo:UBERON_0001135, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0002113 obo:IAO_0000115 "A paired organ of the urinary tract which has the production of urine as its primary function." ; obo:RO_0002171 obo:UBERON_0000160 ; obo:UBPROP_0000001 "One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO]" ; obo:UBPROP_0000007 "renal" ; obo:UBPROP_0000202 obo:FMA_264815 ; oboInOwl:hasDbXref "AAO:0000250", "BTO:0000671", "CALOHA:TS-0510", "EFO:0000929", "EMAPA:17373", "EV:0100096", "FMA:7203", "GAID:423", "MA:0000368", "MAT:0000119", "MESH:D007668", "MIAA:0000119", "NCIT:C12415", "SCTID:181414000", "UMLS:C0022646", "Wikipedia:Kidney", "XAO:0003267", "galen:Kidney" ; oboInOwl:hasNarrowSynonym "reniculate kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002113" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "kidney" ; rdfs:subClassOf obo:UBERON_0000489, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005095 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001008 ], _:genid122626, _:genid122629 . obo:UBERON_0002114 obo:IAO_0000115 "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." ; obo:UBPROP_0000001 "The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000007 "duodenal" ; obo:UBPROP_0000008 "In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum.", "In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz." ; oboInOwl:hasDbXref "AAO:0010402", "BTO:0000365", "CALOHA:TS-0214", "EFO:0000851", "EMAPA:18852", "EV:0100073", "FMA:7206", "GAID:284", "MA:0000338", "MAT:0000044", "MESH:D004386", "MIAA:0000044", "NCIT:C12263", "SCTID:181247007", "UMLS:C0013303", "VHOG:0000052", "Wikipedia:Duodenum", "XAO:0000236", "galen:Duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal intestine", "upper intestine" ; oboInOwl:id "UBERON:0002114" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "duodenum" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0002108 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001166 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002108 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg"^^xsd:anyURI . obo:UBERON_0002115 obo:IAO_0000115 "The portion of the small intestine that extends from the duodenum to the ileum." ; obo:IAO_0000116 "TODO consider ZFA:0001323 mid intestine, see also small intestine" ; obo:UBPROP_0000001 "The first two fifth of the small intestine beyond the duodenum. It extends from the end of the duodenum to the ileum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000007 "jejunal" ; obo:UBPROP_0000008 "The jejunum is the middle section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms middle intestine or mid-gut may be used instead of jejunum.[Wikipedia:Jejunum]" ; oboInOwl:hasDbXref "BTO:0000657", "CALOHA:TS-0496", "EFO:0001333", "EMAPA:18666", "EV:0100074", "FMA:7207", "GAID:318", "MA:0000340", "MAT:0000045", "MESH:D007583", "MIAA:0000045", "NCIT:C12388", "SCTID:181248002", "UMLS:C0022378", "VHOG:0000053", "Wikipedia:Jejunum", "galen:Jejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinum jejunum", "mid-intestine", "middle intestine" ; oboInOwl:id "UBERON:0002115" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "jejunum" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002108 ], _:genid122651 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg"^^xsd:anyURI . obo:UBERON_0002116 obo:IAO_0000115 "The portion of the small intestine that extends from the jejunum to the colon." ; obo:IAO_0000116 "TODO consider ZFA:0000706 posterior intestine, see also colon" ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; obo:UBPROP_0000007 "ileal" ; obo:UBPROP_0000008 "The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may be used instead of ileum.[Wikipedia:Ileum]" ; oboInOwl:hasDbXref "AAO:0010403", "BTO:0000620", "CALOHA:TS-0472", "EFO:0001334", "EMAPA:32764", "EV:0100075", "FMA:7208", "GAID:315", "MA:0000339", "MAT:0000282", "MESH:D007082", "MIAA:0000282", "NCIT:C12387", "SCTID:181249005", "UMLS:C0020885", "VHOG:0000647", "Wikipedia:Ileum", "XAO:0000237", "galen:Ileum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal intestine", "intestinum ileum", "lower intestine", "posterior intestine" ; oboInOwl:id "UBERON:0002116" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ileum" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002108 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg"^^xsd:anyURI . obo:UBERON_0002118 obo:IAO_0000115 "An ovary that is part of a right side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37367", "FMA:7213", "MA:0001705", "NCIT:C33487", "SCTID:280123002", "UMLS:C0227873" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002118" ; a owl:Class ; rdfs:label "right ovary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000992 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0002119 obo:IAO_0000115 "An ovary that is part of a left side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000008 "In some elasmobranchs, the left ovary does not mature, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" ; oboInOwl:hasDbXref "EMAPA:37366", "FMA:7214", "MA:0001704", "NCIT:C32969", "SCTID:280124008", "UMLS:C0227874" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002119" ; a owl:Class ; rdfs:label "left ovary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid121904 ] . obo:UBERON_0002120 obo:IAO_0000115 "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]." ; obo:UBPROP_0000001 "A kidney formed of nephric tubules arising in the anterior region of the nephric ridge; forms only as a transient embryonic structure. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.748][VHOG]", "Organ that serves as a transient kidney, providing osmoregulation during early developmental stages and then degenerating during metamorphosis.[AAO]", "The embryonic kidney, present at the level of the third somite, is composed of two glomeruli fused at the midline, two pronephric tubules, and paired bilateral pronephric ducts that modify the composition of the blood filtrate before delivering it to the cloaca for excretion.Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" ; obo:UBPROP_0000007 "pronephric" ; oboInOwl:hasAlternativeId "UBERON:0005794" ; oboInOwl:hasDbXref "AAO:0011089", "BTO:0001541", "EFO:0000927", "EHDAA2:0001570", "EHDAA:1017", "EMAPA:16579", "FMA:72170", "MAT:0000117", "MESH:D060910", "MIAA:0000117", "NCIT:C34280", "SCTID:308804007", "TAO:0000151", "UMLS:C0231048", "VHOG:0000037", "Wikipedia:Pronephros", "XAO:0002000", "ZFA:0000151" ; oboInOwl:hasExactSynonym "pronephric kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "archinephron", "embryonic kidney", "pronephron" ; oboInOwl:id "UBERON:0002120" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Once the more complex mesonephros forms the pronephros undergoes apoptosis in amphibians. In fishes the nephron degenerates but the organ remains and becomes a component of the immune system[Wikipedia:Pronephros]. // TODO - check developmental relationships. Note that we previously include the ZFA/XAO terms under the more specific 'pronephric kidney', but these are now merged. TODO GCI: relationship: capable_of GO:0030104" ; rdfs:label "pronephros" ; rdfs:subClassOf obo:UBERON_0002113, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005754 ], _:genid122686, _:genid122688, _:genid122690 . obo:UBERON_0002122 obo:IAO_0000115 "The fibrous connective tissue surrounding the thymus." ; oboInOwl:hasDbXref "EMAPA:19306", "FMA:72204", "MA:0000766", "NCIT:C33770", "SCTID:188181003", "UMLS:C0229945" ; oboInOwl:hasExactSynonym "thymic capsule", "thymus capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002122" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "capsule of thymus" ; rdfs:subClassOf obo:UBERON_0003893 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0002123 obo:IAO_0000115 "The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes." ; obo:UBPROP_0000010 "Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin[WP]" ; oboInOwl:hasDbXref "BTO:0002934", "EMAPA:35863", "FMA:72205", "MA:0000767", "NCIT:C33774", "SCTID:188262003", "UMLS:C0229948", "Wikipedia:Thymus#Cortex" ; oboInOwl:hasExactSynonym "thymic cortex", "thymus cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002123" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "cortex of thymus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000542 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002293 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0045058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0002124 obo:IAO_0000115 "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." ; oboInOwl:hasDbXref "BTO:0004560", "EFO:0001969", "EMAPA:19305", "FMA:72206", "MA:0000771", "NCIT:C33775", "SCTID:188344009", "UMLS:C0229949", "Wikipedia:Thymus#Medulla" ; oboInOwl:hasExactSynonym "medulla of thymus gland", "thymus gland medulla", "thymus medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002124" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "medulla of thymus" ; rdfs:subClassOf obo:UBERON_0000958, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0002125 obo:IAO_0000115 "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." ; obo:UBPROP_0000008 "in the mouse, the lobes of the thymus are not subdivided into lobules but only in the central medulla and a peripheral cortex (i.e. there is no distinct sublobulation). In humans, the two thymus lobes are composed of many lobules of various sizes which contain follicles, each comprising a medulla and a cortex. in the rat, the thymus is partially subdivided into lobules separated by thin bands of connective tissue which are continuous with the thin connective tissue capsule.[MP]" ; obo:UBPROP_0000010 "Lymphocytes, reticular cells and macrophages are found in the lobules" ; oboInOwl:hasDbXref "FMA:72215", "MA:0000770", "NCIT:C33772", "SCTID:187882006", "UMLS:C1522462" ; oboInOwl:hasExactSynonym "lobule of thymus", "thymic lobule", "thymus lobule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002125" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thymus lobule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005483 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000235 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000432 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000542 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002370 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid121953 ] . obo:UBERON_0002128 obo:IAO_0000115 "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." ; obo:RO_0002171 obo:UBERON_0002597, obo:UBERON_0006840, obo:UBERON_0007634 ; obo:UBPROP_0000008 "In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound[GO:0021718]", "The SOC displays a significant interspecies variation, being largest in bats and rodents and smaller in primates." ; oboInOwl:hasDbXref "BAMS:SOC", "BIRNLEX:1307", "DHBA:12462", "EMAPA:35840", "EV:0100263", "FMA:72247", "HBA:9177", "MA:0001026", "MBA:398", "MESH:D065832", "UMLS:C0175427", "VHOG:0001381", "Wikipedia:Superior_olivary_complex", "neuronames:569" ; oboInOwl:hasExactSynonym "nucleus olivaris superior", "superior olivary nuclei" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "regio olivaris superioris", "superior olivary nucleus", "superior olivary nucleus (Barr & Kiernan)", "superior olive" ; oboInOwl:id "UBERON:0002128" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "superior olivary complex" ; rdfs:subClassOf obo:UBERON_0007245, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016490 ], _:genid122742 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png"^^xsd:anyURI . obo:UBERON_0002129 obo:IAO_0000115 "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." ; obo:RO_0002171 obo:UBERON_0002130 ; obo:UBPROP_0000001 "The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function[GO][GO:0021695]." ; oboInOwl:hasDbXref "BAMS:CB", "BAMS:CBX", "BAMS:CbCx", "BIRNLEX:1566", "BM:CB-Cbx", "BTO:0000043", "CALOHA:TS-2000", "DHBA:10657", "DMBA:16939", "EMAPA:35211", "EV:0100294", "FMA:72248", "GAID:596", "HBA:4697", "MA:0000199", "MBA:528", "MESH:D002525", "NCIT:C49216", "SCTID:361593004", "UMLS:C0007759", "UMLS:C1284087", "VHOG:0001597", "Wikipedia:Cerebellar_cortex", "neuronames:647" ; oboInOwl:hasExactSynonym "cortex of cerebellar hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortex cerebellaris", "cortex cerebelli" ; oboInOwl:id "UBERON:0002129" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The circuits in the cerebellar cortex look similar across all classes of vertebrates, including fish, reptiles, birds, and mammals (e.g., Fig. 2). This has been taken as evidence that the cerebellum performs functions important to all vertebrate species. (Wikipedia)" ; rdfs:label "cerebellar cortex" ; rdfs:subClassOf obo:UBERON_0002020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ], _:genid121980, _:genid122758 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png"^^xsd:anyURI . obo:UBERON_0002130 obo:IAO_0000115 "The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP]." ; obo:RO_0002171 obo:UBERON_0002129 ; oboInOwl:hasAlternativeId "UBERON:0004007" ; oboInOwl:hasDbXref "BAMS:CBN", "BAMS:CBn", "BAMS:DCb", "BAMS:DNC", "BIRNLEX:1568", "DHBA:10660", "EV:0100299", "FMA:72249", "GAID:599", "HBA:4780", "MBA:519", "MESH:D002529", "UMLS:C0007763", "Wikipedia:Deep_cerebellar_nuclei", "neuronames:682" ; oboInOwl:hasExactSynonym "central nuclei", "cerebellar nuclei", "deep cerebellar nuclear complex", "deep cerebellar nuclei", "intracerebellar nuclei", "intrinsic nuclei of cerebellum", "nuclei cerebelli", "roof nuclei-2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei cerebellares", "nuclei cerebellaris", "nuclei cerebelli" ; oboInOwl:id "UBERON:0002130" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "cerebellar nuclear complex" ; rdfs:subClassOf obo:UBERON_0007245, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/23/Gray707.png"^^xsd:anyURI . obo:UBERON_0002132 obo:IAO_0000115 "The largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers." ; obo:RO_0002171 obo:UBERON_0002153 ; obo:UBPROP_0000003 "One or more deep cerebellar nuclei appear in agnathans, sharks, ropefishes, lungfishes, Latimeria, and amphibians. Reptiles have two nuclei (a medial and a lateral), and birds and mammals have three nuclei (a medial, a lateral, and an interposed nucleus). The medial nucleus of mammals is known as the fastigial nucleus, and the lateral nucleus is known as the dentate nucleus.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0008996" ; oboInOwl:hasDbXref "BAMS:DN", "BAMS:Dt", "BIRNLEX:1171", "BM:CB-CBL", "BTO:0003836", "EV:0100300", "FMA:72260", "HBA:12946", "MA:0001008", "MBA:846", "SCTID:279221005", "UMLS:C0086120", "VHOG:0001700", "Wikipedia:Dentate_nucleus", "neuronames:683" ; oboInOwl:hasExactSynonym "dentate cerebellar nucleus", "lateral cerebellar nucleus", "lateral nucleus of cerebellum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dentate nucleus", "dentate nucleus (Vicq d'Azyr)", "dentatothalamocortical fibers", "nucleus dentatus", "nucleus dentatus cerebelli", "nucleus lateralis cerebelli" ; oboInOwl:id "UBERON:0002132" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "dentate nucleus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002130 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/23/Gray707.png"^^xsd:anyURI . obo:UBERON_0002133 obo:IAO_0000115 "A cardial valve in the atrioventricular region that separates the atrium from the ventricle and prevent backflow from the ventricles into the atria during systole." ; obo:UBPROP_0000001 "The atrioventricular valve has four distinct leaflets oriented anterior, posterior, left, and right of the atrioventricular orifice. Hu et al. 2001.[TAO]", "Valve in the heart through which blood flows from the atria to the ventricles. [TFD][VHOG]" ; obo:UBPROP_0000003 "The conus arteriosus is the most distal part of the primitive fish heart and forms the connection between the ventricle and the ventral aorta. At the sinoatrial, the atrioventricular, and the ventriculoconal junctions, valves developed to prevent backflow of blood during relaxation of the preceding compartment.[uncertain][VHOG]" ; obo:UBPROP_0000012 "in ZFA this is part of both atrium and ventricle, but we use a connecting relationship here; see also notes for left and right." ; oboInOwl:hasDbXref "EHDAA2:0000153", "EHDAA:7421", "EMAPA:35154", "FMA:7233", "MA:0002789", "SCTID:11124005", "TAO:0005064", "VHOG:0001472", "Wikipedia:Heart_valve#Atrioventricular_valves", "ZFA:0005064", "galen:AtrioventricularValve" ; oboInOwl:hasExactSynonym "AV valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrio-ventricular valve" ; oboInOwl:id "UBERON:0002133" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "atrioventricular valve" ; rdfs:subClassOf obo:UBERON_0000946, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005994 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002082 ], _:genid122793, _:genid122798, _:genid122800 . obo:UBERON_0002134 obo:IAO_0000115 "An atrioventricular valve that is part of the outflow part of the right atrium." ; obo:UBPROP_0000001 "The three-segmented valve of the heart that keeps blood in the right ventricle from flowing back into the right atrium. [TFD][VHOG]" ; obo:UBPROP_0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" ; obo:UBPROP_0000012 "FMA part_ofs changed to connects" ; oboInOwl:hasDbXref "EHDAA2:0004029", "EHDAA:7427", "EMAPA:17873", "FMA:7234", "GAID:567", "MA:0000090", "MESH:D014261", "NCIT:C12805", "RETIRED_EHDAA2:0002081", "SCTID:181288007", "UMLS:C0040960", "VHOG:0000816", "Wikipedia:Tricuspid_valve", "galen:TricuspidValve" ; oboInOwl:hasExactSynonym "right atrioventricular valve", "valva atrioventricularis dextra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "valvula tricuspidalis" ; oboInOwl:id "UBERON:0002134" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tricuspid valve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002078 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005965 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002135 obo:IAO_0000115 "An atrioventricular valve that is part of the outflow part of the left atrium." ; obo:UBPROP_0000001 "A valve of the heart, composed of two triangular flaps, that is located between the left atrium and left ventricle and regulates blood flow between these chambers. [TFD][VHOG]" ; obo:UBPROP_0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" ; obo:UBPROP_0000012 "FMA part_ofs changed to connects" ; oboInOwl:hasDbXref "EFO:0003933", "EHDAA2:0000168", "EMAPA:17871", "FMA:7235", "GAID:565", "MA:0000088", "MESH:D008943", "NCIT:C12753", "SCTID:181286006", "UMLS:C0026264", "VHOG:0000817", "Wikipedia:Mitral_valve", "galen:MitralValve" ; oboInOwl:hasExactSynonym "left atrioventricular valve", "valva atrioventricularis sinistra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bicuspid valve", "valva mitralis" ; oboInOwl:id "UBERON:0002135" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mitral valve" ; rdfs:subClassOf _:genid122826, _:genid122828, _:genid122830 ; owl:disjointWith obo:UBERON_0007120 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005966 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002137 obo:IAO_0000115 "Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA]." ; obo:UBPROP_0000001 "The valve between the left ventricle of the heart and the ascending aorta, consisting of three semilunar cusps. [TFD][VHOG]" ; oboInOwl:hasDbXref "BTO:0004628", "EFO:0003879", "EHDAA2:0000134", "EHDAA:4410", "EMAPA:17870", "FMA:7236", "GAID:563", "MA:0000087", "MESH:D001021", "NCIT:C12670", "SCTID:181287002", "UMLS:C0003501", "VHOG:0000815", "Wikipedia:Aortic_valve", "galen:AorticValve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "valva aortae" ; oboInOwl:id "UBERON:0002137" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Human variation: It is normally tricuspid (with three leaflets), although in 1% of the population it is found to be congenitally bicuspid (two leaflets)" ; rdfs:label "aortic valve" ; rdfs:subClassOf obo:UBERON_0005623, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005956 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002146 obo:IAO_0000115 "The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery." ; obo:UBPROP_0000001 "The valve with semilunar cusps at the entrance to the pulmonary trunk from the right ventricle of the heart. [TFD][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001577", "EHDAA:4412", "EMAPA:17872", "FMA:7246", "GAID:566", "MA:0000089", "MESH:D011664", "NCIT:C12775", "SCTID:181289004", "UMLS:C0034086", "VHOG:0000814", "Wikipedia:Pulmonary_valve", "galen:PulmonaryValve" ; oboInOwl:hasExactSynonym "pulmonic valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "valva trunci pulmonalis" ; oboInOwl:id "UBERON:0002146" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pulmonary valve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005623 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002012 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg"^^xsd:anyURI . obo:UBERON_0002148 obo:IAO_0000115 "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." ; obo:IAO_0000116 "TODO - check ZFA/pons. also GO says part of dorsorostral pons" ; obo:RO_0002171 obo:UBERON_0002047, obo:UBERON_0002267, obo:UBERON_0002587, obo:UBERON_0003004 ; oboInOwl:hasDbXref "BAMS:CAE", "BAMS:LC", "BIRNLEX:905", "BM:Pons-LC", "BTO:0001408", "DHBA:12819", "DMBA:16972", "EFO:0001963", "EMAPA:35502", "FMA:72478", "GAID:577", "HBA:9148", "MA:0001017", "MBA:147", "MESH:D008125", "NCIT:C97333", "SCTID:369016004", "TAO:0000539", "UMLS:C0023951", "Wikipedia:Locus_ceruleus", "ZFA:0000539", "neuronames:583" ; oboInOwl:hasExactSynonym "Noradrenergic cell group A6", "blue nucleus", "caerulean nucleus", "locus caeruleus", "locus coeruleu", "locus coeruleus", "nucleus caeruleus", "nucleus of locus caeruleus", "nucleus pigmentosus pontis", "substantia ferruginea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "loci coeruleus", "locus cinereus", "locus coeruleus (Vicq d'Azyr)", "nucleus loci caerulei" ; oboInOwl:id "UBERON:0002148" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "locus ceruleus" ; rdfs:subClassOf obo:UBERON_0002308, obo:UBERON_8440015, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048243 ], _:genid122855 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png"^^xsd:anyURI . obo:UBERON_0002149 obo:IAO_0000115 "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." ; obo:RO_0002171 obo:UBERON_0002143, obo:UBERON_0002147, obo:UBERON_0002151, obo:UBERON_0002633, obo:UBERON_0002682, obo:UBERON_0002963, obo:UBERON_0002968, obo:UBERON_0003011, obo:UBERON_0007632 ; oboInOwl:hasDbXref "BAMS:SSN", "BAMS:SuS", "BIRNLEX:1131", "DHBA:12435", "EHDAA2:0004646", "EMAPA:37756", "FMA:72482", "HBA:9194", "MA:0001027", "MBA:462", "SCTID:369028007", "UMLS:C0175447", "Wikipedia:Superior_salivatory_nucleus", "neuronames:590" ; oboInOwl:hasExactSynonym "superior salivary nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus salivarius superior", "nucleus salivatorius cranialis", "nucleus salivatorius rostralis", "nucleus salivatorius superior" ; oboInOwl:id "UBERON:0002149" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "superior salivatory nucleus" ; rdfs:subClassOf obo:UBERON_0000126, obo:UBERON_0004133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 ], _:genid122875, _:genid122878 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png"^^xsd:anyURI . obo:UBERON_0002150 obo:IAO_0000115 "A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)." ; obo:IAO_0000116 "we follow NIF in dividing this into 3 parts. This allows for consistency with ABA" ; obo:UBPROP_0000012 "we make the TAO class disjoint for now as it's not clear if this is the analagous structure" ; oboInOwl:hasDbXref "BAMS:5", "BAMS:scp", "BIRNLEX:1711", "BM:BC", "DHBA:12354", "DMBA:17793", "HBA:9297", "MA:0002746", "MBA:326", "SCTID:279218008", "UMLS:C0152391", "Wikipedia:Superior_cerebellar_peduncle", "neuronames:1736" ; oboInOwl:hasExactSynonym "brachium conjunctivum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crus cerebello-cerebrale", "pedunculus cerebellaris cranialis", "pedunculus cerebellaris rostralis", "pedunculus cerebellaris superior", "scp", "superior cerebelar peduncles", "superior cerebellar peduncle (Galen, Stilling)", "superior cerebellar peduncle (brachium conjuctivum)", "superior cerebellar peduncle (brachium conjunctivum)", "superior peduncle", "tractus cerebello-rubralis", "tractus cerebello-tegmentalis mesencephali" ; oboInOwl:id "UBERON:0002150" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "superior cerebellar peduncle" ; rdfs:subClassOf obo:UBERON_0007416 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray704.png"^^xsd:anyURI . obo:UBERON_0002152 obo:IAO_0000115 "Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM)." ; oboInOwl:hasDbXref "BAMS:BP", "BAMS:bp", "BAMS:mcp", "BIRNLEX:1529", "BM:Pons-BP", "DHBA:12768", "FMA:72515", "HBA:9294", "MA:0002745", "MBA:78", "MESH:D065837", "NIFSTD_RETIRED:birnlex_1699", "SCTID:279219000", "UMLS:C0152392", "Wikipedia:Middle_cerebellar_peduncle", "neuronames:620" ; oboInOwl:hasExactSynonym "brachium pontis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brachium pontis (stem of middle cerebellar peduncle)", "crus cerebelli ad pontem", "crus ponto-cerebellare", "mid-cerebellar peduncle", "pedunculus cerebellaris medialis", "pedunculus cerebellaris medius", "pedunculus cerebellaris pontinus" ; oboInOwl:id "UBERON:0002152" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "middle cerebellar peduncle" ; rdfs:subClassOf obo:UBERON_0007416, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ], _:genid122916 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray705.png"^^xsd:anyURI . obo:UBERON_0002165 obo:IAO_0000115 "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." ; obo:UBPROP_0000001 "Layer that lines the lumen of the heart.[TAO]", "Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO]", "Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber." ; oboInOwl:hasAlternativeId "UBERON:0006225" ; oboInOwl:hasDbXref "AAO:0010408", "BTO:0000387", "CALOHA:TS-2075", "EFO:0000821", "EHDAA2:0004153", "EMAPA:17868", "EMAPA:32686", "EV:0100021", "FMA:7280", "GAID:550", "MA:0000076", "MAT:0000455", "MESH:D004699", "NCIT:C13004", "SCTID:362013006", "TAO:0001320", "UMLS:C0014124", "VHOG:0000084", "Wikipedia:Endocardium", "XAO:0000066", "ZFA:0001320", "galen:Endocardium" ; oboInOwl:hasExactSynonym "endocardial lining", "endocardial tissue", "heart endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "heart endocardial tissue" ; oboInOwl:id "UBERON:0002165" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "fixed in GO to reflect FMA. See email to David/Varsha June 18 2010" ; rdfs:label "endocardium" ; rdfs:subClassOf obo:UBERON_0002523, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005316 ], _:genid122931 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png"^^xsd:anyURI . obo:UBERON_0002166 obo:IAO_0000115 "Endocardium that is part of the atrium." ; oboInOwl:hasDbXref "EMAPA:32745", "FMA:7284", "MA:0000077", "SCTID:192001005", "TAO:0002169", "VHOG:0000606", "ZFA:0001614" ; oboInOwl:hasExactSynonym "Cardiac atria endocardium", "atrial endocardium", "atrium endocardium", "atrium of heart endocardium", "cardiac atrium endocardium", "endocardium of Cardiac atria", "endocardium of atrium of heart", "endocardium of cardiac atrium", "endocardium of heart atrium", "heart atrium endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrium endocardial tissue" ; oboInOwl:id "UBERON:0002166" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endocardium of atrium" ; rdfs:subClassOf obo:UBERON_0002165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002081 ] ; owl:equivalentClass _:genid122151 . obo:UBERON_0002167 obo:IAO_0000115 "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." ; obo:UBPROP_0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0001730", "EHDAA:4969", "EMAPA:17661", "FMA:7309", "MA:0000426", "NCIT:C33483", "SCTID:361967000", "UMLS:C0225706", "VHOG:0000301", "Wikipedia:Right_lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002167" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "right lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002048 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000170 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png"^^xsd:anyURI . obo:UBERON_0002168 obo:IAO_0000115 "Lung which consists of the left upper lobe and left lower lobe.[FMA]." ; obo:UBPROP_0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0000943", "EHDAA:4947", "EMAPA:17653", "FMA:7310", "MA:0000425", "NCIT:C32967", "SCTID:361982005", "UMLS:C0225730", "VHOG:0000618", "Wikipedia:Left_lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002168" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "left lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002048 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000170 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png"^^xsd:anyURI . obo:UBERON_0002169 obo:IAO_0000115 "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters." ; oboInOwl:hasAlternativeId "UBERON:0008871" ; oboInOwl:hasDbXref "BTO:0000061", "EMAPA:35119", "FMA:7317", "MA:0000418", "NCIT:C32057", "SCTID:361964007", "UMLS:C0225691", "Wikipedia:Alveolar_sac" ; oboInOwl:hasExactSynonym "pulmonary alveolar sac", "sacculus alveolaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "air sac" ; oboInOwl:id "UBERON:0002169" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "alveolar sac" ; rdfs:subClassOf _:genid122185, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0008874 ], _:genid122975, _:genid122977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008874 ] ) ] . obo:UBERON_0002180 obo:IAO_0000115 "The white substance of the spinal cord lying on either side between the ventral median fissure and the ventral roots of the spinal nerves." ; oboInOwl:hasDbXref "FMA:74003", "NLX:379", "SCTID:362429007", "TAO:0000605", "Wikipedia:Ventral_funiculus", "ZFA:0000605", "neuronames:1304" ; oboInOwl:hasExactSynonym "anterior funiculus", "anterior funiculus of spinal cord", "anterior white column of spinal cord", "funiculus anterior medullae spinalis", "ventral funiculus", "ventral funiculus of spinal cord", "ventral white column of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventral funiculi" ; oboInOwl:id "UBERON:0002180" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ventral funiculus of spinal cord" ; rdfs:subClassOf obo:UBERON_0006127, _:genid122986 ; owl:disjointWith obo:UBERON_0002258 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg"^^xsd:anyURI . obo:UBERON_0002185 obo:IAO_0000115 "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." ; obo:RO_0002161 obo:NCBITaxon_8507 ; obo:UBPROP_0000001 "Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000007 "bronchial" ; obo:UBPROP_0000008 "In humans, the main bronchus is histologically identical to trachea; 2ary and 3ary bronchi are not; epithelium becomes simple columnar, goblet cell number decreases, elastic fibers in lamina propria increases, distribution more uniform. Muscular layer between mucosa and submucosa appears. cartilage rings become discontinuous plates connected by fibrous connective tissue" ; oboInOwl:hasDbXref "BTO:0001340", "CALOHA:TS-1229", "EFO:0000932", "EMAPA:32689", "EV:0100041", "FMA:7409", "GAID:346", "MA:0000436", "MAT:0000133", "MESH:D001980", "MIAA:0000133", "NCIT:C12683", "SCTID:181215002", "UMLS:C0006255", "VHOG:0000262", "Wikipedia:Bronchus", "XAO:0000121" ; oboInOwl:hasExactSynonym "bronchi", "bronchial trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchial tissue" ; oboInOwl:id "UBERON:0002185" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "bronchus" ; rdfs:subClassOf obo:UBERON_0000117, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg"^^xsd:anyURI . obo:UBERON_0002186 obo:IAO_0000115 "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching." ; obo:UBPROP_0000007 "bronchiolar" ; obo:UBPROP_0000010 "lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer" ; obo:UBPROP_0000012 "In FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however, there are two distinct terms for the corresponding epithelium." ; oboInOwl:hasDbXref "BTO:0002375", "CALOHA:TS-2003", "EHDAA:8171", "EHDAA:8183", "EHDAA:8199", "EHDAA:8221", "EMAPA:32697", "FMA:7410", "MA:0000422", "MESH:D055745", "NCIT:C12684", "SCTID:278982001", "UMLS:C0006270", "VHOG:0000675", "Wikipedia:Bronchiole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchioli", "bronchiolus" ; oboInOwl:id "UBERON:0002186" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole." ; rdfs:label "bronchiole" ; rdfs:subClassOf obo:UBERON_0000117, _:genid123004, _:genid123006, _:genid123008 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0002187 obo:IAO_0000115 "The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls." ; oboInOwl:hasDbXref "BTO:0003223", "EMAPA:36282", "FMA:7411", "MA:0000424", "NCIT:C33754", "SCTID:278981008", "UMLS:C0225666", "Wikipedia:Terminal_bronchiole" ; oboInOwl:hasExactSynonym "bronchiolus terminalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchioli terminalis", "terminal bronchiole tube" ; oboInOwl:id "UBERON:0002187" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "terminal bronchiole" ; rdfs:subClassOf obo:UBERON_0002186 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0002190 obo:IAO_0000115 "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." ; obo:UBPROP_0000001 "the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156]" ; oboInOwl:hasAlternativeId "UBERON:0008875" ; oboInOwl:hasBroadSynonym "panniculus adiposus" ; oboInOwl:hasDbXref "BTO:0004042", "EMAPA:35829", "FMA:74315", "MA:0000473" ; oboInOwl:hasExactSynonym "fatty layer of subcutaneous tissue", "hypodermis fat layer", "panniculus adiposus (tela subcutanea)", "panniculus adiposus telae subcutaneae", "subcutaneous fat layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fatty layer of superficial fascia", "subcutaneous fat" ; oboInOwl:id "UBERON:0002190" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "subcutaneous adipose tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0002193 obo:IAO_0000115 "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." ; oboInOwl:hasDbXref "CALOHA:TS-2018", "EHDAA2:0004615", "EMAPA:18765", "FMA:74562", "MA:0000013" ; oboInOwl:hasExactSynonym "hematolymphoid system", "lymphomyeloid complex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "haemolymphoid system" ; oboInOwl:id "UBERON:0002193" ; a owl:Class ; rdfs:label "hemolymphoid system" ; rdfs:subClassOf obo:UBERON_0000467 . obo:UBERON_0002194 obo:IAO_0000115 "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers." ; obo:UBPROP_0000008 "from its internal surface are given off a number of membranous processes or trabeculae, consisting, in man, of connective tissue, with a small admixture of plain muscle fibers; but in many of the lower animals composed almost entirely of involuntary muscle[WP]" ; oboInOwl:hasDbXref "EMAPA:35524", "FMA:74604", "MA:0000739", "NCIT:C33028", "SCTID:327532004", "UMLS:C0229699", "Wikipedia:Lymph_node_capsule" ; oboInOwl:hasExactSynonym "capsula nodi lymphoidei", "lymph node capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002194" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "capsule of lymph node" ; rdfs:subClassOf obo:UBERON_0003893, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/92/Lymphknoten_(Schwein).jpg"^^xsd:anyURI . obo:UBERON_0002195 obo:IAO_0000115 "Membranous process coming from capsule of lymph node[WP]." ; oboInOwl:hasDbXref "FMA:74605", "MA:0000746", "NCIT:C33035", "UMLS:C1184179", "Wikipedia:Lymph_node_trabeculae" ; oboInOwl:hasExactSynonym "lymph node trabecula", "lymph node trabeculae", "lymph node trabeculum", "trabeculae of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002195" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "trabecula of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png"^^xsd:anyURI . obo:UBERON_0002196 obo:IAO_0000115 "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]." ; obo:UBPROP_0000001 "Region of the pituitary gland derived from the buccal protrusion consisting of three regions.[AAO]", "The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin. In contrast to mamalian vertebrates, the adenohypophysis remains in a subepithelial position and there exists no equivalent of Rathke's pouch in zebrafish. Herzog et al, 2004.[TAO]" ; obo:UBPROP_0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" ; obo:UBPROP_0000008 "In contrast to mammalian vertebrates, the adenohypophysis remains in a subepithelial position and there exists no equivalent of Rathke's pouch in zebrafish", "While in most basal fish and tetrapods the adenohypophyseal anlagen invaginates to form Rathke's pouch, in teleost fish the adenohypophyseal placode does not invaginate but rather maintains its initial organization forming a solid structure in the head[NCBIBook:NBK53175]." ; oboInOwl:hasBroadSynonym "AHP" ; oboInOwl:hasDbXref "AAO:0010540", "BAMS:AHY", "BAMS:AL", "BAMS:APit", "BIRNLEX:1581", "BM:AHy", "BTO:0000040", "CALOHA:TS-0794", "EFO:0000230", "EHDAA2:0000109", "EMAPA:17514", "FMA:74627", "MA:0000177", "MESH:D010903", "NCIT:C12772", "SCTID:245532007", "TAO:0001282", "UMLS:C0032008", "UMLS:C1280369", "VHOG:0000141", "Wikipedia:Adenohypophysis", "ZFA:0001282", "neuronames:407" ; oboInOwl:hasExactSynonym "anterior hypophysis", "anterior lobe (hypophysis)", "anterior lobe of hypophysis", "anterior lobe of pituitary", "anterior lobe of pituitary gland", "anterior pituitary", "lobus anterior (glandula pituitaria)", "lobus anterior hypophysis", "pituitary gland, anterior lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior lobe of the pituitary", "anterior pituitary gland", "cranial lobe", "lobus anterior", "pituitary anterior lobe", "pituitary glandanterior lobe", "rostral lobe" ; oboInOwl:id "UBERON:0002196" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "adenohypophysis" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000438 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002312 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000007 ], _:genid123055, _:genid123058, _:genid123060, _:genid123063 ; owl:disjointWith obo:UBERON_0002198 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray1181.png"^^xsd:anyURI . obo:UBERON_0002198 obo:IAO_0000115 "The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon." ; obo:IAO_0000116 "request magnocellular cell from CL. Request oxytocin secretion from GO. Notes: 'The hypophysis or pituitary gland is derived, in part from an ectodermal outpocketing of the stomodeum (Rathke's Pouch) and in part from the floor of the diencephalon'" ; obo:UBPROP_0000001 "The infundibular part of the pituitary gland consisting of two regions.[AAO]" ; obo:UBPROP_0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" ; obo:UBPROP_0000012 "todo - resolve EMAPA and EHDAA2 models, include future neurohypophysis (TS15-19)? relationship to infundibular recess of 3rd ventricle (TS15-19)" ; oboInOwl:hasBroadSynonym "NHP" ; oboInOwl:hasDbXref "AAO:0010537", "BAMS:NHP", "BAMS:NHY", "BAMS:NL", "BAMS:PPit", "BIRNLEX:1586", "BM:NY", "BTO:0000937", "CALOHA:TS-0815", "DMBA:15691", "EHDAA2:0001271", "EHDAA:7536", "EMAPA:17519", "FMA:74628", "MA:0000178", "MESH:D010904", "NCIT:C12773", "SCTID:245527006", "TAO:0001271", "UMLS:C0032009", "UMLS:C1280368", "VHOG:0000142", "Wikipedia:Neurohypophysis", "ZFA:0001271", "neuronames:401" ; oboInOwl:hasExactSynonym "infundibular process", "lobus nervosus neurohypophysis", "lobus posterior (glandula pituitaria)", "lobus posterior hypophysis", "neural lobe", "neural lobe of pituitary", "neural lobe of pituitary gland", "neuro hypophysis", "neurohypophysis", "pituitary gland, posterior lobe", "posterior lobe of pituitary", "posterior lobe of pituitary gland", "posterior pituitary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobus nervosus", "lobus posterior", "pituitary gland neural lobe", "pituitary gland, neural lobe", "posterior lobe of hypophysis", "posterior pituitary gland" ; oboInOwl:id "UBERON:0002198" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neurohypophysis" ; rdfs:subClassOf obo:UBERON_0010134, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 ], _:genid123087, _:genid123090, _:genid123092 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG"^^xsd:anyURI . obo:UBERON_0002199 obo:IAO_0000115 "The dermis, epidermis and hypodermis." ; obo:IAO_0000232 "in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition." ; obo:UBPROP_0000001 "Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO]", "Surface structure that is the outer protective covering of the body.[VSAO]", "The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO]" ; obo:UBPROP_0000007 "integumental", "integumentary" ; oboInOwl:hasDbXref "AAO:0000239", "BTO:0000634", "EMAPA:37504", "FMA:74657", "TAO:0000368", "VSAO:0000029", "Wikipedia:Integument", "ZFA:0000368", "galen:Integument" ; oboInOwl:hasExactSynonym "dermis plus epidermis plus hypodermis", "integumentum commune", "skin and subcutaneous tissue", "skin plus hypodermis", "the integument" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermal system", "dermoid system", "skin", "tegument", "vertebrate integument" ; oboInOwl:id "UBERON:0002199" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "integument" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002072 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002097 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000468 ], _:genid123118 . obo:UBERON_0002200 obo:IAO_0000115 "Vasculature that is part of a head [Automatically generated definition]." ; oboInOwl:hasDbXref "EFO:0003656", "FMA:74710", "TAO:0001267", "XAO:0004152", "ZFA:0001267" ; oboInOwl:hasExactSynonym "adult head vascular network", "adult head vasculature", "cranial vasculature", "head vascular network", "vascular network of adult head", "vascular network of head", "vasculature of adult head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "head vasculature" ; oboInOwl:id "UBERON:0002200" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vasculature of head" ; rdfs:subClassOf obo:UBERON_0002049 ; owl:equivalentClass _:genid122329 . obo:UBERON_0002201 obo:IAO_0000115 "A vasculature that is part of a trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:74712", "TAO:0005024", "ZFA:0005024" ; oboInOwl:hasExactSynonym "torso vascular network", "torso vasculature", "trunk vascular network", "trunk vasculature", "vascular network of torso", "vascular network of trunk", "vasculature of torso" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002201" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "vasculature of trunk" ; rdfs:subClassOf obo:UBERON_0002049 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0002202 obo:IAO_0000115 "A submucosa that is part of a trachea." ; oboInOwl:hasDbXref "BTO:0002115", "EMAPA:35879", "FMA:7472", "MA:0001860", "NCIT:C49307", "SCTID:4419000", "UMLS:C0225586" ; oboInOwl:hasExactSynonym "submucosa of windpipe", "trachea submucosa", "tracheal submucosa", "windpipe submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of trachea" ; oboInOwl:id "UBERON:0002202" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "submucosa of trachea" ; rdfs:subClassOf obo:UBERON_0000009 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0002203 obo:IAO_0000115 "Vasculature that is part of the eye region." ; obo:UBPROP_0000012 "not part of the eye in ZFA. Note this changed to a blood vessel in ZFA" ; oboInOwl:hasDbXref "FMA:74743", "SCTID:123846009", "TAO:0007057", "ZFA:0007057" ; oboInOwl:hasExactSynonym "eye vascular network", "ocular blood vessel", "ocular vasculature", "vascular network of eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye vasculature", "optic vasculature" ; oboInOwl:id "UBERON:0002203" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vasculature of eye" ; rdfs:subClassOf obo:UBERON_0002200, _:genid123168 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0002204 obo:IAO_0000115 "Anatomical system that consists of the muscular and skeletal systems." ; obo:UBPROP_0000001 "Anatomical system that provides locomotion and physical support to the organism.[AAO]" ; obo:UBPROP_0000003 "There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG]" ; obo:UBPROP_0000007 "musculoskeletal" ; oboInOwl:hasDbXref "AAO:0010546", "CALOHA:TS-1311", "EMAPA:32714", "EV:0100139", "FMA:7482", "GAID:98", "MA:0002418", "MESH:D009141", "NCIT:C12754", "SCTID:278858007", "UMLS:C0026860", "VHOG:0001275", "VSAO:0000031", "Wikipedia:Musculoskeletal_system", "XAO:0000168" ; oboInOwl:hasExactSynonym "musculo-skeletal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002204" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "musculoskeletal system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000383 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001434 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0040011 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid123178 ; owl:disjointWith obo:UBERON_0002294, obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002207 obo:IAO_0000115 "A cartilaginous extension to the distal part of the sternum." ; obo:IAO_0000232 "this class may represent a mixed bony-cartilage element, or it may be the superclass of either purely cartilage or purely ossified elements" ; obo:UBPROP_0000008 "usually ossified in the adult human. By age 15 to 29, the xiphoid usually fuses to the body of the sternum with a fibrous joint. Unlike the synovial articulation of major joints, this is non-movable. Much the way the first seven ribs articulate with the sternum, the cartilage in the celiac plexus joins on the xiphoid process, reinforcing it, and indirectly attaches the costal cartilage to the sternum." ; oboInOwl:hasDbXref "EMAPA:18725", "FMA:7488", "MA:0001334", "NCIT:C33895", "SCTID:272711000", "UMLS:C0043356", "Wikipedia:Xiphoid_process" ; oboInOwl:hasExactSynonym "xiphisternum", "xiphoid process", "xiphoid process of sternum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metasternum", "processus xiphoideus", "xiphoid", "xiphoid process", "xiphoideus", "xiphosternal junction", "xyphoid" ; oboInOwl:id "UBERON:0002207" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "xiphoid process" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ], _:genid123186 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray117.png"^^xsd:anyURI . obo:UBERON_0002208 obo:IAO_0000115 "One of the bony segments of the sternum[TFD]." ; oboInOwl:hasDbXref "EMAPA:18724", "FMA:7489", "MA:0001333", "SCTID:95955004", "Wikipedia:Sternebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sternebral bone" ; oboInOwl:id "UBERON:0002208" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Note that some definitions state that this a segment of the primordial sternum." ; rdfs:label "sternebra" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006295 ], _:genid123200 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg"^^xsd:anyURI . obo:UBERON_0002209 obo:IAO_0000115 "Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA]." ; obo:UBPROP_0000001 "A joint where fibrous tissue such as ligament connects two calcified tissues.[TAO]" ; oboInOwl:hasDbXref "AEO:0000178", "EHDAA2:0003178", "EMAPA:35344", "FMA:7492", "MA:0000321", "SCTID:37772004", "TAO:0005156", "Wikipedia:Fibrous_joint", "ZFA:0005156" ; oboInOwl:hasExactSynonym "articulatio fibrosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "junctura fibrosa" ; oboInOwl:id "UBERON:0002209" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "fibrous joint" ; rdfs:subClassOf obo:UBERON_0011134, _:genid123206 . obo:UBERON_0002210 obo:IAO_0000115 "Fibrous joint in which the articulating bones or cartilages of the vertebral column and the limbs as well as articulating ossicles, are connected by skeletal ligaments or membranes. Examples: Intervertebral syndesmosis, inferior tibiofibular joint.[FMA]." ; oboInOwl:hasDbXref "EMAPA:37465", "FMA:7494", "MA:0001500", "SCTID:89358004", "Wikipedia:Syndesmosis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002210" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "syndesmosis" ; rdfs:subClassOf obo:UBERON_0002209, obo:UBERON_0002213 . obo:UBERON_0002213 obo:IAO_0000115 "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." ; oboInOwl:hasDbXref "EMAPA:36581", "FMA:7496", "MA:0000320", "SCTID:58442004", "TAO:0005155", "Wikipedia:Cartilaginous_joint", "ZFA:0005155" ; oboInOwl:hasExactSynonym "articulatio cartilaginea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "junctura cartilaginea" ; oboInOwl:id "UBERON:0002213" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cartilaginous joint" ; rdfs:subClassOf obo:UBERON_0011134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011134 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0002215 obo:IAO_0000115 "Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA]." ; obo:IAO_0000116 "WP considers epiphyseal plates as subtypes of this", "consider adding link to hyaline cartilage" ; oboInOwl:hasDbXref "EMAPA:35846", "FMA:7497", "MA:0001501", "SCTID:42903008", "Wikipedia:Synchondrosis" ; oboInOwl:hasExactSynonym "cartilago epiphysialis", "primary cartilaginous joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epiphysial cartilage" ; oboInOwl:id "UBERON:0002215" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "synchondrosis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002209 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001994 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray297.png"^^xsd:anyURI . obo:UBERON_0002216 obo:IAO_0000115 "Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA]." ; obo:IAO_0000116 "consider adding fibrocartilage class" ; oboInOwl:hasDbXref "EMAPA:37758", "FMA:7498", "MA:0001504", "SCTID:1584001", "Wikipedia:Symphysis" ; oboInOwl:hasExactSynonym "secondary cartilaginous joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002216" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "symphysis" ; rdfs:subClassOf obo:UBERON_0002209, obo:UBERON_0002213 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray298.png"^^xsd:anyURI . obo:UBERON_0002217 obo:IAO_0000115 "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." ; obo:UBPROP_0000001 "Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]" ; oboInOwl:hasDbXref "AEO:0000183", "CALOHA:TS-2138", "EHDAA2:0003183", "FMA:7501", "MA:0000322", "NCIT:C32461", "SCTID:113234001", "TAO:0005153", "Wikipedia:Synovial_joint", "ZFA:0005153", "galen:SynovialJoint" ; oboInOwl:hasExactSynonym "articulatio synoviale", "diarthroses", "diarthrosis", "diarthrosis joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diarthrodial joints" ; oboInOwl:id "UBERON:0002217" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "synovial joint" ; owl:disjointWith obo:UBERON_0011134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0001484 ] ) ] . obo:UBERON_0002221 obo:IAO_0000115 "Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]." ; obo:UBPROP_0000001 "Anatomical structure that is a membranous gap between bones of the skull.[TAO]" ; oboInOwl:hasDbXref "FMA:75438", "MA:0001465", "NCIT:C32621", "SCTID:272681004", "TAO:0001738", "UMLS:C0224548", "Wikipedia:Fontanelle", "ZFA:0005536" ; oboInOwl:hasExactSynonym "fontanel", "fontanelles", "fontanels" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fonticuli cranii" ; oboInOwl:id "UBERON:0002221" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "fontanelle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/1795" ; rdfs:subClassOf obo:UBERON_0002209, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003685 ], _:genid123242 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png"^^xsd:anyURI . obo:UBERON_0002224 obo:IAO_0000115 "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." ; obo:UBPROP_0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" ; oboInOwl:hasDbXref "EMAPA:36497", "FMA:7565", "GAID:93", "MA:0000032", "MESH:D035423", "NCIT:C12905", "SCTID:243949006", "UMLS:C0230139", "Wikipedia:Thoracic_cavity" ; oboInOwl:hasExactSynonym "cavitas thoracis", "cavity of chest", "cavity of thorax", "chest cavity", "pectoral cavity", "space of thoracic compartment", "thoracic lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002224" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "thoracic cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg"^^xsd:anyURI . obo:UBERON_0002228 obo:IAO_0000115 "An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses." ; obo:UBPROP_0000001 "Endochondral bone that is intersegmental and rod-shaped, forming in the peritoneal membrane and attached to the vertebral parapophyses. Ribs protect and support internal organs.[TAO]", "Endochondral, rodlike element that articulates with the transverse process and parapophysis (double-headed rib), or with the transverse process only (single-headed rib); it extends into the body wall and provides a site for muscle attachment.[AAO]" ; obo:UBPROP_0000007 "costal" ; obo:UBPROP_0000008 "In most vertebrates, ribs surround the chest. In some species, especially snakes, ribs may provide support and protection for the entire body" ; obo:UBPROP_0000009 "They protect and support internal organs and enable lungs to expand by expanding the chest." ; oboInOwl:hasDbXref "AAO:0000545", "CALOHA:TS-2209", "EFO:0003066", "EMAPA:18010", "FMA:7574", "GAID:245", "MA:0000315", "MESH:D012272", "NCIT:C12782", "SCTID:302523002", "TAO:0000538", "UMLS:C0035561", "VHOG:0001154", "Wikipedia:Rib", "ZFA:0000538", "galen:Rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal rib", "pleural rib", "ribs" ; oboInOwl:id "UBERON:0002228" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "rib" ; rdfs:subClassOf _:genid123265 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015019 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0002231 oboInOwl:hasDbXref "EMAPA:36014", "FMA:7577", "MA:0001416", "NCIT:C52728", "SCTID:263361000", "UMLS:C0448161" ; oboInOwl:hasExactSynonym "corpus costae", "rib body", "rib shaft", "shaft of rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002231" ; a owl:Class ; rdfs:label "body of rib" ; rdfs:subClassOf obo:UBERON_0005913, _:genid123272 . obo:UBERON_0002234 obo:IAO_0000115 "A proximal phalanx that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37307", "FMA:75816", "MA:0001395", "NCIT:C52786", "SCTID:181986000", "SCTID:361325003", "UMLS:C0730117" ; oboInOwl:hasExactSynonym "hand proximal phalanx", "phalanx proximalis manus", "proximal manual phalanx", "proximal phalanx of finger", "proximal phalanx of fore digit", "proximal phalanx of hand", "proximal phalanx of manual digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002234" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manus" ; rdfs:subClassOf obo:UBERON_0001436, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0002374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0002235 obo:IAO_0000115 "The tubercle of a rib is an eminence on the posterior surface, at the junction of the neck and body of the rib, and nearer the lower than the upper border. It consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs[WP]." ; oboInOwl:hasDbXref "EMAPA:37736", "FMA:7583", "MA:0001417", "NCIT:C52729", "SCTID:361104005", "UMLS:C0222809", "Wikipedia:Tubercle_(rib)" ; oboInOwl:hasExactSynonym "rib tubercle", "tuberculum costae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002235" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tubercle of rib" ; rdfs:subClassOf _:genid123292, _:genid123294 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002231 ] ) ] . obo:UBERON_0002236 obo:IAO_0000115 "The nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it." ; obo:IAO_0000116 "we currently model this as part of the rib, is this correct?" ; oboInOwl:hasDbXref "BTO:0001721", "EMAPA:35262", "FMA:7591", "MA:0000106", "MESH:D066186", "NCIT:C32391", "SCTID:244703004", "UMLS:C0222787", "Wikipedia:Costal_cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilagines costales", "cartilago costalis", "sternal cartilage" ; oboInOwl:id "UBERON:0002236" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "costal cartilage" ; rdfs:subClassOf obo:UBERON_0007844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002228 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cc/Gray315.png"^^xsd:anyURI . obo:UBERON_0002237 obo:IAO_0000115 "A rib that is ventrally connected to the sternum." ; oboInOwl:hasDbXref "EMAPA:37774", "FMA:7592", "MA:0001419", "SCTID:368044009", "Wikipedia:True_ribs" ; oboInOwl:hasExactSynonym "costa vera" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "costae verae" ; oboInOwl:id "UBERON:0002237" ; a owl:Class ; rdfs:label "true rib" ; owl:disjointWith obo:UBERON_0002238 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002228 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray115.png"^^xsd:anyURI . obo:UBERON_0002238 obo:IAO_0000115 "A rib that is not directly ventrally connected to the sternum." ; oboInOwl:hasDbXref "EMAPA:37493", "FMA:7594", "MA:0001398", "SCTID:368045005", "Wikipedia:False_rib" ; oboInOwl:hasExactSynonym "costa spuria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "asternal ribs", "costae spuriae" ; oboInOwl:id "UBERON:0002238" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "false rib" ; rdfs:subClassOf obo:UBERON_0002228 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray115.png"^^xsd:anyURI . obo:UBERON_0002239 obo:IAO_0000115 "A rib that is not connected to sternum or sternal cartilage." ; obo:UBPROP_0000013 "We synonymize 'free rib' with 'floating rib' - this case it referes to caudal ribs, but you can have free ribs (i.e. non-attached ventrally) in other places . Should we just synonymize this with 'floating rib'? see Primate Anatomy: An Introduction by Friderun Ankel-Simons pg. 275" ; oboInOwl:hasDbXref "EMAPA:37494", "FMA:7595", "MA:0001399", "SCTID:368046006", "Wikipedia:Floating_rib" ; oboInOwl:hasExactSynonym "costa fluitante", "free rib", "vertebral rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "costae fluctuantes", "costae fluitantes" ; oboInOwl:id "UBERON:0002239" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "floating rib" ; rdfs:subClassOf obo:UBERON_0002238 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Skeleton_woman_back.png"^^xsd:anyURI . obo:UBERON_0002240 obo:IAO_0000115 "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." ; obo:IAO_0000116 "TODO - add superclass to unify with VNC?" ; obo:RO_0002171 obo:UBERON_0000955 ; obo:UBPROP_0000001 "Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010151", "BAMS:SP", "BAMS:Spinal", "BIRNLEX:1709", "BM:SpC", "BTO:0001279", "CALOHA:TS-0953", "DHBA:12890", "DMBA:17651", "EFO:0000110", "EHDAA2:0001255", "EHDAA:2863", "EMAPA:17577", "EV:0100316", "FMA:7647", "GAID:695", "MA:0000216", "MAT:0000183", "MESH:D013116", "MIAA:0000183", "NCIT:C12464", "SCTID:180959008", "TAO:0000075", "UMLS:C0037925", "VHOG:0000601", "Wikipedia:Spinal_cord", "XAO:0000020", "ZFA:0000075", "neuronames:22" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "SpC", "cerebro-cerebellar fissure", "cerebrocerebellar fissure", "fissura cerebro-cerebellaris", "fissura cerebrocerebellaris", "medulla spinalis", "spinal cord structure", "spinal medulla" ; oboInOwl:id "UBERON:0002240" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "spinal cord" ; rdfs:subClassOf obo:UBERON_0000489, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003076 ], _:genid123325, _:genid123328, _:genid123330 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg"^^xsd:anyURI . obo:UBERON_0002241 obo:IAO_0000115 "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." ; obo:IAO_0000116 "we follow the standard evolutionary classification and treat this as endoskeletal. This means what MA calls 'chondrocranium' must in fact be neurocranium, as it includes parts of the dermatocranium (e.g. frontal, parietal)" ; obo:UBPROP_0000001 "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[AAO]", "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[TAO]" ; obo:UBPROP_0000007 "chondrocranial" ; obo:UBPROP_0000008 "covers the brain dorsally in chondrichthyans" ; oboInOwl:hasDbXref "AAO:0010169", "EHDAA2:0000243", "EMAPA:17681", "TAO:0001424", "VHOG:0000288", "Wikipedia:Chondrocranium", "ZFA:0001424" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calvarium", "neurocranium" ; oboInOwl:id "UBERON:0002241" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "chondrocranium" ; rdfs:subClassOf obo:UBERON_0011159, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001703 ] . obo:UBERON_0002242 obo:IAO_0000115 "The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord." ; obo:UBPROP_0000010 "The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[Wikipedia:Nucleus_pulposus]" ; obo:UBPROP_0000012 "we group two FMA classes together" ; oboInOwl:hasDbXref "BTO:0003626", "EMAPA:18008", "FMA:13550", "FMA:76703", "MA:0000112", "MESH:D000070614", "SCTID:316586000", "Wikipedia:Nucleus_pulposus" ; oboInOwl:hasExactSynonym "nucleus pulposus (diskus intervertebralis)", "pulpy nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus propulsus", "nucleus propulsus of intervertebral disk", "nucleus pulposus of intervertebral disk" ; oboInOwl:id "UBERON:0002242" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Function noyes: It functions to distribute hydraulic pressure in all directions within each disc under compressive loads." ; rdfs:label "nucleus pulposus" ; rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0002384, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001066 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_37397 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_60924 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000138 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0011860 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001066 ], _:genid123357 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png"^^xsd:anyURI . obo:UBERON_0002244 obo:IAO_0000115 "One of the bones of the upper jaw situated between and in front of the maxillae[VHOG]." ; obo:IAO_0000116 "requires checking embryonic vs adult; isa fetal organ part in FMA; adult bone of upper jaw in AAO and ZFA; split. Note that we have loops if we add develops_from UBERON:0005620 primary palate" ; obo:RO_0002161 obo:NCBITaxon_7901 ; obo:UBPROP_0000001 "Dermal bone that forms the anteriormost element of the upper jaw. It articulates with the maxilla posterodorsally and its antimere medially. The premaxilla is paired.[TAO]", "One of the bones of the upper jaw situated between and in front of the maxillae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]", "Paired, intramembranous bones located at the anterior end of the skull; they form the anterior-most segment of the maxillary arch.[AAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps inter-premaxillary joint (TAO:0001950)[TAO]", "relationship loss: overlaps mesethmoid-premaxillary joint (TAO:0001676)[TAO]", "relationship loss: overlaps premaxillary-maxillary joint (TAO:0002260)[TAO]" ; obo:UBPROP_0000003 "(...) in all higher vertebrates a premaxilla is present (...) (reference 1); Although the presence of a tooth-bearing outer buccal arcade (premaxilla, maxilla, dentary) is cited as a common character of Osteichthyes, dipnoans lack all three bones (...) (reference 2).[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0002253" ; oboInOwl:hasDbXref "AAO:0000461", "EHDAA:6962", "EHDAA:8033", "EMAPA:17641", "FMA:76869", "FMA:77231", "MA:0001493", "SCTID:308884009", "TAO:0000567", "VHOG:0000426", "Wikipedia:Incisive_bone", "ZFA:0000567" ; oboInOwl:hasExactSynonym "premaxillae", "premaxillary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "incisive bone", "os incisivum", "premaxilla bone", "premaxillary bone" ; oboInOwl:id "UBERON:0002244" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "premaxilla" ; rdfs:subClassOf obo:UBERON_0002514, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid123366, _:genid123368, _:genid123371 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray160.png"^^xsd:anyURI . obo:UBERON_0002245 obo:IAO_0000115 "A paired regions of the cerebellum that lie outside and lateral to the central vermis[MP]. The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres. The lateral hemisphere is considered the portion of the cerebellum to develop most recently. [WP,unvetted]." ; oboInOwl:hasDbXref "BAMS:CH", "BIRNLEX:1575", "DHBA:10659", "DMBA:16920", "EMAPA:35218", "FMA:76925", "HBA:12930", "MA:0000200", "MBA:1073", "NCIT:C32726", "SCTID:362411002", "UMLS:C0228465", "Wikipedia:Cerebellar_hemisphere", "neuronames:1214" ; oboInOwl:hasExactSynonym "cerebellar hemisphere", "cerebellum hemisphere", "hemisphere of cerebellum", "hemisphere of cerebellum [H II - H X]", "hemispherium cerebelli [H II - H X]", "hemispherium cerebelli [hII-hX]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellar hemispheres", "hemispherium cerebelli" ; oboInOwl:id "UBERON:0002245" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cerebellar hemisphere" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002129 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002037 ], _:genid122569 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png"^^xsd:anyURI . obo:UBERON_0002250 obo:IAO_0000115 "The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries." ; oboInOwl:hasDbXref "EMAPA:37109", "FMA:77155", "GAID:504", "MA:0002021", "MESH:D011150", "NCIT:C33337", "SCTID:181350008", "UMLS:C0032649", "Wikipedia:Popliteal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria poplitea" ; oboInOwl:id "UBERON:0002250" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "popliteal artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002060 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a2/Popliteal_artery.png"^^xsd:anyURI . obo:UBERON_0002257 obo:IAO_0000115 "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." ; obo:UBPROP_0000001 "The anterior horn of the spinal cord (or anterior cornu, or anterior column, or ventral horn) is the ventral (front) grey matter section of the spinal cord. The anterior horn contains motor neurons that affect the axial muscles while the posterior horn receives information regarding touch and sensation. The anterior horn is where the cell bodies of alpha motorneurons are located[Wikipedia:Anterior_horn_of_spinal_cord]." ; oboInOwl:hasDbXref "BAMS:VH", "BIRNLEX:2668", "BTO:0005151", "EMAPA:18575", "EMAPA:35794", "FMA:256541", "MA:0001134", "NCIT:C33859", "SCTID:279443000", "TAO:0000702", "UMLS:C0228569", "UMLS:C0228590", "VHOG:0001288", "Wikipedia:Anterior_horn_of_spinal_cord", "ZFA:0000702", "neuronames:1751" ; oboInOwl:hasExactSynonym "anterior gray column of spinal cord", "anterior gray horn of spinal cord", "anterior grey column of spinal cord", "anterior horn", "columna grisea anterior medullae spinalis", "spinal cord anterior horn", "spinal cord ventral horn", "ventral gray column of spinal cord", "ventral gray matter of spinal cord", "ventral grey column of spinal cord", "ventral grey horn", "ventral horn spinal cord", "ventral region of spinal cord", "ventral spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior column", "anterior column of the spinal cord", "anterior horn (spinal cord)", "cornu anterius medullae spinalis", "ventral horn of the spinal cord", "ventral horns spinal cord" ; oboInOwl:id "UBERON:0002257" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ventral horn of spinal cord" ; rdfs:subClassOf obo:UBERON_0016550, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002315 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000100 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002315 ], _:genid123405 . obo:UBERON_0002258 obo:IAO_0000115 "The white substance of the spinal cord lying on either side between the posterior median sulcus and the dorsal root." ; obo:IAO_0000116 "ZFA class is undefined. We currently do not place this as part of the DCML pathway as this would lead to taxon constraint violations." ; oboInOwl:hasDbXref "FMA:77461", "SCTID:362432005", "TAO:0000501", "Wikipedia:Dorsal_funiculus", "ZFA:0000501", "neuronames:1692" ; oboInOwl:hasExactSynonym "dorsal funiculus", "dorsal funiculus of spinal cord", "dorsal white column of spinal cord", "funiculus dorsalis", "funiculus posterior medullae spinalis", "posterior funiculus", "posterior funiculus of spinal cord", "posterior white column of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002258" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal funiculus of spinal cord" ; rdfs:subClassOf obo:UBERON_0006127, _:genid123427 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg"^^xsd:anyURI . obo:UBERON_0002263 obo:IAO_0000115 "The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule. [WP,unvetted]." ; obo:IAO_0000116 "TODO - add parts" ; obo:UBPROP_0000012 "the EMAPA class is unclear" ; oboInOwl:hasDbXref "BTO:0002250", "EMAPA:18208", "EMAPA:19147", "EV:0100186", "FMA:77615", "MA:0000896", "NCIT:C32977", "SCTID:279319002", "UMLS:C0162342", "Wikipedia:Lentiform_nucleus", "neuronames:1234" ; oboInOwl:hasExactSynonym "nucleus lenticularis", "nucleus lentiformis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lenticular nucleus", "nucleus lentiformis" ; oboInOwl:id "UBERON:0002263" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "lentiform nucleus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001874 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001875 ], _:genid123436, _:genid123438 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fc/Gray741.png"^^xsd:anyURI . obo:UBERON_0002264 obo:IAO_0000115 "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]." ; obo:RO_0002171 obo:UBERON_0001950, obo:UBERON_0002421 ; obo:UBPROP_0000001 "Part of the rostral part of the cerebrum where axons of olfactory cells from the nasal mucosa terminate. Projects onto olfactory parts of pallium via olfactory tracts", "Part of the telencephalon comprised of anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits.[AAO]", "Segment of neural tree organ which is continuous with a set of olfactory nerves and an olfactory tract[FMA:77624].", "The part of the forebrain in which the olfactory nerves end and the olfactory tracts originate. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]" ; obo:UBPROP_0000008 "In most vertebrates, the olfactory bulb is the most rostral (forward) part of the brain. In humans, however, the olfactory bulb is on the inferior (bottom) side of the brain. The olfactory bulb is supported and protected by the cribriform plate which in mammals, separates it from the olfactory epithelium, and which is perforated by olfactory nerve axons. The bulb is divided into two distinct structures, the main olfactory bulb, and the accessory olfactory bulb", "Note that in uberon 'main olfactory bulb' is a separate class, but some ontologies may treat this as partially synonymous. The distinction may only make sense in tetrapods with a vomeronasal organ (olfactory nerves terminate in OB in fishes and in main OB in tetrapods - Butler and Hodos)" ; obo:UBPROP_0000011 "the olfactory bulbs develop as bilateral evaginations from a region of the prosencephalic neural plate intercalated between the septal and the cortical anlagen (Cobos et al. 2001b, Rubenstein et al. 1998). Comparing the structure of the olfactory bulb among vertebrate species, such as the leopard frog and the lab mouse, reveals that they all share the same fundamental layout(WP)." ; oboInOwl:hasDbXref "AAO:0010165", "BAMS:DLB", "BAMS:OB", "BAMS:Olf", "BIRNLEX:1137", "BM:Tel-OB", "BTO:0000961", "CALOHA:TS-0702", "DHBA:10307", "EHDAA2:0004705", "EMAPA:32809", "EV:0100173", "FMA:77624", "GAID:633", "HBA:9303", "MA:0000194", "MESH:D009830", "NCIT:C28401", "SCTID:279394006", "TAO:0000402", "UMLS:C0028936", "VHOG:0000033", "Wikipedia:Olfactory_bulb", "XAO:0004180", "ZFA:0000402", "neuronames:279" ; oboInOwl:hasExactSynonym "bulbus olfactorius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bulbus olfactorius", "bulbus olfactorius (Morgagni)", "olfactory lobe", "olfactory lobe (Barr & Kiernan)" ; oboInOwl:id "UBERON:0002264" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "olfactory bulb" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005366 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007608 ], _:genid122626, _:genid123450, _:genid123452 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/1543%2CVesalius%27OlfactoryBulbs.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/f/f9/1543,Vesalius%27OlfactoryBulbs.jpg"^^xsd:anyURI . obo:UBERON_0002265 obo:IAO_0000115 "White matter tract that contains projections from the olfactory bulb to other parts of the brain." ; obo:UBPROP_0000001 "A nervelike, white band composed primarily of nerve fibres originating from the mitral cells and tufted cells of the olfactory bulb but also containing the scattered cells of the anterior olfactory nucleus[BTO:0003647].", "The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. It lies in the olfactory sulcus on the inferior surface of the frontal lobe, and divides posteriorly into two striæ, a medial olfactory stria and a lateral olfactory stria.[Wikipedia].", "Tract of brain which is continuous with olfactory bulb and the cerebral cortex.[FMA]", "White matter tract that contains projections from the olfactory bulb to the olfactory cortex (Maryann Martone)" ; obo:UBPROP_0000008 "in animals with a long snout, the olfactory tract is long, whereas it is short in short-snouted animals such as primates. In some birds the tract per se does not exist as the bulb is connected directly to the cerebral hemisphere.[ISBN:0471888893]" ; obo:UBPROP_0000012 "The definition was adapted from the NIFSTD class which has been retired. It has been generalized so it is applicable to various different kinds of olfactory tracts found in different taxa." ; oboInOwl:hasDbXref "BAMS:olf", "BIRNLEX:1663", "BTO:0003647", "DHBA:12073", "DHBA:12074", "EMAPA:35615", "FMA:77626", "HBA:9302", "MA:0000975", "NCIT:C33207", "SCTID:362356008", "UMLS:C0162435", "Wikipedia:Olfactory_tract", "neuronames:283" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "olfactory peduncle", "olfactory stalk", "pedunclulus olfactorius", "tractus olfactorium", "tractus olfactorius" ; oboInOwl:id "UBERON:0002265" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "olfactory tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011299 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007702 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png"^^xsd:anyURI . obo:UBERON_0002268 obo:IAO_0000115 "An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ." ; obo:IAO_0000116 "An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint" ; obo:UBPROP_0000012 "fma general anatomical term. xao has no subtypes (but Johnstons organ develops from this). An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint" ; oboInOwl:hasDbXref "AAO:0010180", "BTO:0001772", "FBbt:00005158", "FMA:77659", "VHOG:0000287", "XAO:0000273" ; oboInOwl:hasExactSynonym "olfactory organ", "olfactory sense organ", "olfactory sensory organ" ; oboInOwl:hasNarrowSynonym "main olfactory organ", "primary olfactory organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "olfactory neuroepithelium", "organ olfactus", "organum olfactorium" ; oboInOwl:id "UBERON:0002268" ; oboInOwl:inSubset core:functional_classification ; a owl:Class ; rdfs:label "olfactory organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000207 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005725 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000020 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050911 ] ) ] . obo:UBERON_0002270 obo:IAO_0000115 "An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens." ; obo:UBPROP_0000001 "Artery that is internal to the eye. Isogai et al. 2001.[TAO]" ; obo:UBPROP_0000008 "In humans, Usually fully regressed before birth, its purpose is to supply nutrient to the developing lens in the growing fetus. During the tenth week of development the lens grows independent of a blood supply and the hyaloid artery usually regresses. Its proximal portion remains as the central artery of the retina. Regression of the hyaloid artery leaves a clear central zone through the vitreous called the hyaloid canal or Cloquet's canal. Occasionally the artery may not fully regress, resulting in the condition persistent hyaloid artery. More commonly, small remnants of the artery may remain. Free remnants can sometimes be seen as 'floaters'. An anterior remnant of the hyaloid artery can be seen in some people as Mittendorf's dot, a small pinpoint-like scar on the posterior surface of the lens. A posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister's papilla" ; oboInOwl:hasDbXref "EHDAA2:0004072", "EMAPA:19242", "FMA:77670", "SCTID:308790003", "TAO:0005045", "VHOG:0001478", "Wikipedia:Hyaloid_artery", "XAO:0004155", "ZFA:0005045" ; oboInOwl:hasExactSynonym "arteria hyaloidea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Cloquet's canal", "Cloquets canal", "central artery of retina", "hyaloid arteries" ; oboInOwl:id "UBERON:0002270" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hyaloid artery" ; rdfs:subClassOf obo:UBERON_0001637, obo:UBERON_0005492, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001619 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000965 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0006010 ], _:genid123503, _:genid123505, _:genid123507, _:genid123509, _:genid123513 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0002275 obo:IAO_0000115 "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." ; obo:IAO_0000232 "this class denotes the generic structure, and not a specific one such as medullary or pontine reticular formation." ; obo:UBPROP_0000008 "It is essential for governing some of the basic functions of higher organisms, and is one of the phylogenetically oldest portions of the brain." ; obo:UBPROP_0000012 "FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure" ; oboInOwl:hasDbXref "BAMS:RET", "EMAPA:35188", "FMA:77719", "MA:0003185", "MESH:D012154", "NLX:143558", "SCTID:361552007", "Wikipedia:Reticular_formation", "neuronames:1223" ; oboInOwl:hasExactSynonym "brain stem reticular formation", "brainstem reticular formation", "reticular formation (classical)", "reticular formation of the brainstem" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002275" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "reticular formation" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png"^^xsd:anyURI . obo:UBERON_0002279 obo:IAO_0000115 "At the hinder part of the medial wall of the vestibule is the orifice of the vestibular aqueduct, which extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein, and contains a tubular prolongation of the membranous labyrinth, the ductus endolymphaticus, which ends in a cul-de-sac between the layers of the dura mater within the cranial cavity. [WP,unvetted]." ; oboInOwl:hasDbXref "FMA:77821", "GAID:885", "MA:0001186", "MESH:D014723", "Wikipedia:Vestibular_aqueduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aqueductus vestibuli" ; oboInOwl:id "UBERON:0002279" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "vestibular aqueduct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005236 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0036074 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png"^^xsd:anyURI . obo:UBERON_0002285 obo:IAO_0000115 "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere." ; obo:UBPROP_0000001 "The lateral ventricles are part of the ventricular system of the brain. Classified as part of the telencephalon, they are the largest of the ventricles. The lateral ventricles connect to the central third ventricle through the interventricular foramina of Monro[WP].", "The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle[GO]." ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:LV", "BAMS:Tel-V", "BIRNLEX:1263", "BM:Tel-LV", "BTO:0000879", "CALOHA:TS-1230", "DHBA:10596", "DMBA:126651562", "EFO:0001961", "EHDAA2:0001984", "EHDAA:3502", "EHDAA:6576", "EV:0100307", "FMA:78448", "GAID:611", "HBA:9419", "MA:0000192", "MBA:81", "MESH:D020547", "NCIT:C12834", "SCTID:180930008", "TAO:0000696", "UMLS:C0152279", "VHOG:0000643", "Wikipedia:Lateral_ventricle", "ZFA:0000696", "neuronames:209" ; oboInOwl:hasExactSynonym "lateral ventricle", "lateral ventricles", "telencephalic ventricle", "telencephalon lateral ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forebrain ventricle", "lateral ventricle of brain", "tectal ventricle", "telencephalic ventricles", "telencephalic vesicle" ; oboInOwl:id "UBERON:0002285" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "modeled as space in EHDAA2" ; rdfs:label "telencephalic ventricle" ; rdfs:subClassOf _:genid123541 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004086 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png"^^xsd:anyURI . obo:UBERON_0002286 obo:IAO_0000115 "Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone)." ; obo:IAO_0000116 "consider adding class for secondary vesicle precursor" ; obo:UBPROP_0000001 "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from forebrain ventricle (TAO:0001259)[TAO]" ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:3V", "BAMS:V3", "BIRNLEX:714", "BM:Die-3V", "CALOHA:TS-2058", "DHBA:10602", "EHDAA2:0000084", "EMAPA:16900", "EV:0100308", "FMA:78454", "GAID:614", "HBA:9420", "MA:0000182", "MBA:129", "MESH:D020542", "NCIT:C12827", "SCTID:180931007", "TAO:0000161", "UMLS:C0149555", "VHOG:0000007", "Wikipedia:Third_ventricle", "ZFA:0000161", "neuronames:446" ; oboInOwl:hasExactSynonym "3rd ventricle", "ventriculus diencephali" ; oboInOwl:hasNarrowSynonym "diencephalic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diencephalic ventricle", "ventriculus tertius cerebri" ; oboInOwl:id "UBERON:0002286" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "third ventricle" ; rdfs:subClassOf obo:UBERON_0004086, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001894 ], _:genid123556 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png"^^xsd:anyURI . obo:UBERON_0002288 obo:IAO_0000115 "Part of choroid plexus contained in the third ventricle." ; oboInOwl:hasDbXref "BAMS:chp3", "BAMS:cp3v", "EMAPA:18543", "FMA:78462", "HBA:9709", "MA:0000879", "NCIT:C49782", "NLX:18606", "SCTID:61576002", "TAO:0001444", "UMLS:C0152291", "VHOG:0001374", "ZFA:0001444", "neuronames:452" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere of third ventricle", "chorioid plexus of third ventricle", "choroid plexus third ventricle", "diencephalic choroid plexus", "third ventricle chorioid plexus of cerebral hemisphere", "third ventricle choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd ventricle choroid plexus" ; oboInOwl:id "UBERON:0002288" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "choroid plexus of third ventricle" ; rdfs:subClassOf obo:UBERON_0001886, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001886 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ) ] . obo:UBERON_0002289 obo:IAO_0000115 "Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone)." ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "Two distinct classes in ncit. We classify this as a brain ventricle even though it is not classifically regarded as one (3rd = diencephalon, 4th = hindbrains)" ; oboInOwl:hasAlternativeId "UBERON:0005684" ; oboInOwl:hasDbXref "BAMS:AQ", "BAMS:Aq", "BIRNLEX:1261", "BM:MB-AQ", "DHBA:10651", "DHBA:12369", "DMBA:126651722", "EFO:0003501", "EHDAA2:0001163", "EHDAA:3696", "EMAPA:17795", "EV:0100309", "FMA:78467", "GAID:583", "HBA:265505702", "MA:0000208", "MBA:140", "MESH:D002535", "NCIT:C32135", "SCTID:279249003", "TAO:0000159", "UMLS:C0007769", "VHOG:0000832", "Wikipedia:Cerebral_aqueduct", "ZFA:0000159", "ncithesaurus:Cerebral_Aqueduct", "neuronames:509" ; oboInOwl:hasExactSynonym "Sylvian aqueduct", "aqueduct (Sylvius)", "aqueduct of Sylvius", "aqueduct of midbrain", "aqueductus mesencephali", "cerebral aquaduct", "cerebral aqueduct", "cerebral aqueduct of Sylvius", "medial tectal ventricle", "mesencephalic duct", "mesencephalic ventricle", "midbrain cerebral aqueduct", "midbrain ventricle", "tectal ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aqueduct", "aqueduct of Sylvius", "aqueductus mesencephali", "cerebral aqueduct proper", "mesencephalic vesicle" ; oboInOwl:id "UBERON:0002289" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "midbrain cerebral aqueduct" ; rdfs:subClassOf obo:UBERON_0004086, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ], _:genid123578 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Cn3nucleus.png"^^xsd:anyURI . obo:UBERON_0002290 obo:IAO_0000115 "Choroid plexus of the fourth ventricle." ; oboInOwl:hasDbXref "BAMS:chp4", "BAMS:cp4v", "DHBA:12808", "EMAPA:32742", "FMA:78492", "HBA:9710", "MA:0000983", "NCIT:C32308", "NLX:27388", "SCTID:42214001", "TAO:0001446", "UMLS:C0152293", "VHOG:0001375", "ZFA:0001446", "neuronames:638" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere of fourth ventricle", "chorioid plexus of fourth ventricle", "choroid plexus fourth ventricle", "fourth ventricle chorioid plexus of cerebral hemisphere", "fourth ventricle choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "4th ventricle choroid plexus" ; oboInOwl:id "UBERON:0002290" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "choroid plexus of fourth ventricle" ; rdfs:subClassOf obo:UBERON_0001886, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001886 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) ] . obo:UBERON_0002291 obo:IAO_0000115 "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." ; oboInOwl:hasAlternativeId "UBERON:0002220" ; oboInOwl:hasDbXref "BAMS:C", "BAMS:CC", "BIRNLEX:1409", "DHBA:146035108", "DMBA:126652042", "EHDAA2:0004361", "EMAPA:35789", "FMA:78497", "HBA:9422", "MA:0001117", "MBA:164", "NCIT:C12891", "SCTID:279447004", "TAO:0000938", "UMLS:C0459414", "Wikipedia:Central_canal_of_spinal_cord", "ZFA:0000938", "neuronames:1733" ; oboInOwl:hasExactSynonym "canalis centralis", "central canal", "central canal of spinal cord", "spinal cord central canal", "ventricle of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "central canal, spinal cord/medulla" ; oboInOwl:id "UBERON:0002291" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "previously mapped to FMA:75364. Note some ontologies (NIF, SNOMED) subdivide this into lumbar, thoracic, etc. Note we follow FMA in distinguishing between the canal and the lumen" ; rdfs:label "central canal of spinal cord" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001359 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002240 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001359 ], _:genid123610, _:genid123612 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg"^^xsd:anyURI . obo:UBERON_0002293 obo:IAO_0000115 "A bars of hyaline cartilage located between the distal part of a rib and a costal cartilage, connecting the ribs to the sternum ." ; obo:UBPROP_0000008 "In humans, Joints between costal cartilages of ribs 6-9 are plane synovial joints. Articulation between costal cartilage of rib 9 and rib 10 is fibrous" ; oboInOwl:hasDbXref "EMAPA:36490", "FMA:7956", "MA:0001509", "NCIT:C32392", "SCTID:282413008", "UMLS:C0224683", "Wikipedia:Costochondral_joint" ; oboInOwl:hasExactSynonym "articulatio costochondralis", "chondrocostal synchondrosis", "costochondral junction", "costochondral synchondrosis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulationes costochondrales" ; oboInOwl:id "UBERON:0002293" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "costochondral joint" ; rdfs:subClassOf obo:UBERON_0002001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002215 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002236 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010424 ] ) ] . obo:UBERON_0002294 obo:IAO_0000115 "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." ; obo:RO_0002171 obo:UBERON_0016478 ; oboInOwl:hasDbXref "FMA:79646", "GAID:279", "MA:0001273", "MESH:D001659", "NCIT:C12678", "SCTID:361354009", "Wikipedia:Biliary_system" ; oboInOwl:hasExactSynonym "biliary apparatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary tract" ; oboInOwl:id "UBERON:0002294" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "biliary system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002423 ] ; owl:disjointWith obo:UBERON_0002330, obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001173 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006699 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0015721 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png"^^xsd:anyURI . obo:UBERON_0002296 obo:IAO_0000115 "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." ; obo:UBPROP_0000001 "The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO]" ; oboInOwl:hasDbXref "EHDAA2:0004560", "EHDAA:3019", "EHDAA:3033", "EHDAA:3921", "EHDAA:3934", "EHDAA:3957", "EHDAA:3971", "FMA:79795", "SCTID:308823000", "TAO:0005130", "Wikipedia:Mesentery#Development", "ZFA:0005130" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal mesogastrium", "mesenterium dorsale commune" ; oboInOwl:id "UBERON:0002296" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal mesentery" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002095 ], _:genid123651 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png"^^xsd:anyURI . obo:UBERON_0002298 obo:IAO_0000115 "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." ; obo:RO_0002171 obo:UBERON_0001890, obo:UBERON_0002037, obo:UBERON_0002314 ; obo:UBPROP_0000001 "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO]", "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707].", "the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP]" ; oboInOwl:hasDbXref "BAMS:BS", "BIRNLEX:1565", "BTO:0000146", "CALOHA:TS-0093", "EFO:0001962", "EMAPA:32678", "EV:0100241", "FMA:79876", "MA:0000169", "MBA:343", "MESH:D001933", "NCIT:C12441", "SCTID:180925009", "TAO:0002156", "UMLS:C0006121", "VHOG:0001457", "Wikipedia:Brainstem", "ZFA:0001707", "neuronames:236" ; oboInOwl:hasExactSynonym "brain stem", "truncus encephali" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "accessory medullary lamina of pallidum", "lamella pallidi incompleta", "lamina medullaris accessoria", "lamina medullaris incompleta pallidi", "lamina pallidi incompleta", "truncus encephalicus" ; oboInOwl:id "UBERON:0002298" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions)." ; rdfs:label "brainstem" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001896 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001943 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002240 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png"^^xsd:anyURI . obo:UBERON_0002299 obo:IAO_0000115 "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." ; oboInOwl:hasBroadSynonym "alveolus" ; oboInOwl:hasDbXref "BTO:0000060", "CALOHA:TS-0031", "EFO:0001985", "EMAPA:32682", "EV:0100043", "FMA:7318", "GAID:349", "MA:0000420", "MESH:D011650", "SCTID:361364000", "VHOG:0001445", "Wikipedia:Pulmonary_alveolus" ; oboInOwl:hasExactSynonym "alveolus pulmonis", "lung alveolus", "pulmonary alveolus", "respiratory alveolus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alveoli", "alveolus pulmonis", "respiratory alveoli" ; oboInOwl:id "UBERON:0002299" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "alveolus of lung" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008874 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0007585 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0008874 ], _:genid123685 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg"^^xsd:anyURI . obo:UBERON_0002301 obo:IAO_0000115 "One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets." ; oboInOwl:hasBroadSynonym "cortical layer" ; oboInOwl:hasDbXref "ABA:CTX1-6b", "EMAPA:35588", "FMA:83138", "MA:0000186" ; oboInOwl:hasExactSynonym "layer of neocortex", "neocortex layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebral cortex layer", "lamina of neocortex" ; oboInOwl:id "UBERON:0002301" ; a owl:Class ; rdfs:label "layer of neocortex" ; rdfs:subClassOf obo:UBERON_8440004 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] ) ] . obo:UBERON_0002302 obo:IAO_0000115 "The atrial part of middle layer of the heart, comprised of involuntary muscle." ; obo:UBPROP_0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EFO:0003087", "EMAPA:32746", "FMA:83509", "MA:0000081", "SCTID:191910002", "TAO:0001374", "VHOG:0000602", "ZFA:0001374" ; oboInOwl:hasExactSynonym "atrial myocardium", "atrium myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrium cardiac muscle" ; oboInOwl:id "UBERON:0002302" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "myocardium of atrium" ; rdfs:subClassOf obo:UBERON_0002349, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:UBERON_0002305 obo:IAO_0000115 "The layers of the laminar structure of the hippocampus." ; obo:IAO_0000116 "TODO - check NIF xref" ; oboInOwl:hasDbXref "BIRNLEX:1192", "EMAPA:35407", "FMA:277842", "FMA:83679", "MA:0002427", "Wikipedia:Hippocampus_anatomy#Hippocampal_Cells_and_Layers" ; oboInOwl:hasExactSynonym "cytoarchitectural fields of hippocampal formation", "hippocampus layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hippocampus proper layer", "layer of cornu ammonis" ; oboInOwl:id "UBERON:0002305" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "layer of hippocampus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002421 ] ; owl:equivalentClass _:genid122875 . obo:UBERON_0002307 obo:IAO_0000115 "Part of choroid plexus contained in the lateral ventricle." ; oboInOwl:hasDbXref "BAMS:cplv", "DHBA:10601", "EHDAA2:0004449", "EMAPA:17769", "FMA:83711", "HBA:9708", "MA:0000961", "NCIT:C32309", "NLX:32548", "SCTID:70064002", "TAO:0001447", "UMLS:C0152289", "VHOG:0001376", "ZFA:0001447", "neuronames:218" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere of lateral ventricle", "chorioid plexus of lateral ventricle", "choroid plexus telencephalic ventricle", "lateral ventricle chorioid plexus of cerebral hemisphere", "lateral ventricle choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002307" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "choroid plexus of lateral ventricle" ; rdfs:subClassOf obo:UBERON_0001886, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001886 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:UBERON_0002308 obo:IAO_0000115 "A neural nucleus that is part of the brain." ; oboInOwl:hasDbXref "EMAPA:35185", "FMA:83840", "MA:0000811", "NCIT:C49346", "SCTID:426465002", "UMLS:C1706993", "ZFA:0005575" ; oboInOwl:hasExactSynonym "brain nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain nuclei" ; oboInOwl:id "UBERON:0002308" ; a owl:Class ; rdfs:label "nucleus of brain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003528 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0002315 obo:IAO_0000115 "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." ; oboInOwl:hasDbXref "BAMS:Scgrey", "DHBA:146035048", "EMAPA:35792", "FMA:256580", "MA:0000002", "NCIT:C32696", "NLXANAT:100204", "SCTID:279441003", "UMLS:C0475853", "neuronames:2619" ; oboInOwl:hasExactSynonym "gray matter of spinal cord", "gray substance of spinal cord", "grey matter of spinal cord", "grey substance of spinal cord", "spinal cord gray matter", "spinal cord grey matter", "spinal cord grey substance", "substantia grisea medullae spinalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002315" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gray matter of spinal cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0002316 obo:IAO_0000115 "Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system." ; obo:UBPROP_0000001 "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929].", "Multi-tissue structure comprised largely of myelinated axons.[TAO]" ; obo:UBPROP_0000003 "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" ; obo:UBPROP_0000012 "nlx_anat_101177 seems to have been lost in the transition from NIFGA to Neurolex" ; oboInOwl:hasDbXref "AEO:0000139", "AEO:0001011", "EMAPA:35927", "FMA:83929", "HBA:9218", "MA:0001135", "MESH:D066127", "NCIT:C33892", "NLX:412", "NLXANAT:101177", "PBA:294022044", "TAO:0000145", "TAO:0002142", "TAO:0002143", "UMLS:C0682708", "VHOG:0001764", "Wikipedia:White_matter", "ZFA:0001682", "neuronames:2870" ; oboInOwl:hasExactSynonym "CNS tract/commissure", "neuronal white matter", "white matter of neuraxis", "white substance" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CNS tracts and commissures", "CNS white matter", "substantia alba", "white mater" ; oboInOwl:id "UBERON:0002316" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "white matter" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0006135 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg"^^xsd:anyURI . obo:UBERON_0002317 obo:IAO_0000115 "Regional part of cerebellum consisting of the myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles." ; obo:UBPROP_0000001 "CNS white matter that is part of the cerebellum.[TAO]" ; obo:UBPROP_0000012 "in NIF this is a composite structure; in MA and FMA it is explicitly part of cerebellum. This leads to consistency problems with strict parcellation schemes like ABA, see cerebellar peduncles. In NIF this is a composite structure, this is followed partially here in weakening the relationship to overlaps" ; oboInOwl:hasDbXref "BAMS:CB-white", "BAMS:cbw", "BIRNLEX:1562", "DMBA:16926", "EMAPA:35235", "FMA:83943", "HBA:9288", "MA:0002430", "NCIT:C49217", "SCTID:362412009", "TAO:0002183", "UMLS:C0152381", "ZFA:0001708", "neuronames:691" ; oboInOwl:hasExactSynonym "cerebellar white matter", "cerebellum white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellar tracts/commissures", "medullary substance of cerebellum", "substantia centralis medullaris cerebelli", "substantia medullaris cerebelli" ; oboInOwl:id "UBERON:0002317" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "white matter of cerebellum" ; rdfs:subClassOf obo:UBERON_0002316, _:genid123768 . obo:UBERON_0002318 obo:IAO_0000115 "The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." ; oboInOwl:hasDbXref "BAMS:SCwhite", "DHBA:146035088", "EMAPA:35795", "FMA:83945", "MA:0000910", "NCIT:C33893", "SCTID:279436006", "UMLS:C0458457" ; oboInOwl:hasExactSynonym "spinal cord white matter", "spinal cord white matter of neuraxis", "spinal cord white substance", "substantia alba medullae spinalis", "white matter of neuraxis of spinal cord", "white substance of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002318" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "white matter of spinal cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0002319 obo:IAO_0000115 "The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." ; obo:UBPROP_0000007 "mesangial" ; obo:UBPROP_0000012 "WP considers this the same as glomerular mesangium. In MA, glomerular and extraglomerular are distingsuished. FMA class has no definition and is a type of stroma, which is inconsistent with our classification of this here." ; oboInOwl:hasDbXref "BTO:0002494", "EMAPA:28248", "EMAPA:36561", "FMA:84139", "MA:0002617", "NCIT:C33101", "UMLS:C0017655", "Wikipedia:Mesangium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002319" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "mesangium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005215 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0004212 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000119 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000650 ] ) ] . obo:UBERON_0002323 obo:IAO_0000115 "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." ; obo:IAO_0000116 "check the FMA placement here; ncit placement of body cavity here probably not correct" ; obo:UBPROP_0000001 "Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA].", "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]." ; obo:UBPROP_0000008 "In mammals it forms the peritoneal, pleural, and pericardial cavities" ; oboInOwl:hasAlternativeId "UBERON:0000169" ; oboInOwl:hasBroadSynonym "body cavity" ; oboInOwl:hasDbXref "AEO:0000186", "BTO:0001707", "EHDAA2:0000267", "FBbt:00005060", "FMA:85006", "NCIT:C25444", "RETIRED_EHDAA2:0003186", "SCTID:361348008", "TAO:0001438", "UMLS:C0333343", "ZFA:0001438", "galen:BodyCavity" ; oboInOwl:hasExactSynonym "coelomic cavity", "coelomic cavity lumen", "main body cavity", "space of body compartment" ; oboInOwl:hasNarrowSynonym "ventral body cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "celom", "coelom", "coelome", "hemocoel" ; oboInOwl:id "UBERON:0002323" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "coelemic cavity lumen" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0011997 ], _:genid123804 . obo:UBERON_0002324 obo:IAO_0000115 "Any muscle organ that is part of a back [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35161", "FMA:85216", "MA:0000496" ; oboInOwl:hasExactSynonym "back muscle", "back muscle organ", "muscle organ of back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002324" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle of back" ; rdfs:subClassOf obo:UBERON_0001774, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], _:genid123824 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0002325 obo:IAO_0000115 "The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.." ; oboInOwl:hasDbXref "EMAPA:31518", "FMA:85275", "MA:0001686", "NCIT:C49309", "UMLS:C1710584" ; oboInOwl:hasExactSynonym "epithelial tissue of urethra", "urethra epithelial tissue", "urethra epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethral epithelium", "urethral plate", "urethral seam" ; oboInOwl:id "UBERON:0002325" ; a owl:Class ; rdfs:label "epithelium of urethra" ; rdfs:subClassOf obo:UBERON_0003914, obo:UBERON_0005911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0002326 obo:IAO_0000115 "A lamina propria that is part of a urethra [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37785", "FMA:85276", "MA:0001689" ; oboInOwl:hasExactSynonym "lamina propria mucosa of urethra", "lamina propria mucosae of urethra", "urethra lamina propria", "urethra lamina propria mucosa", "urethra lamina propria mucosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethral lamina propria" ; oboInOwl:id "UBERON:0002326" ; a owl:Class ; rdfs:label "lamina propria of urethra" ; rdfs:subClassOf obo:UBERON_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0002327 oboInOwl:hasDbXref "EMAPA:18227", "EMAPA:37720", "FMA:85315", "MA:0001176" ; oboInOwl:hasExactSynonym "intercostal nerve trunk", "intercostal neural trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002327" ; a owl:Class ; rdfs:label "trunk of intercostal nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003727 ] ) ] . obo:UBERON_0002328 obo:IAO_0000115 "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." ; obo:UBPROP_0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]", "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]", "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG]" ; obo:UBPROP_0000007 "notochordal" ; obo:UBPROP_0000011 "In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord." ; oboInOwl:hasDbXref "AAO:0000327", "BTO:0001768", "CALOHA:TS-0690", "EHDAA2:0001277", "EHDAA:1241", "EHDAA:6021", "EMAPA:16191", "EV:0100002", "FMA:85521", "GAID:1311", "MAT:0000281", "MESH:D009672", "NCIT:C12463", "SCTID:308820002", "TAO:0000135", "UMLS:C0028439", "VHOG:0000199", "VSAO:0000032", "Wikipedia:Notochord", "XAO:0000055", "ZFA:0000135", "http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg" ; oboInOwl:hasExactSynonym "embryonic notocord", "notocord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "notochorda" ; oboInOwl:id "UBERON:0002328" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]" ; rdfs:label "notochord" ; rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011137 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000102 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:PR_000014841 ], _:genid123861, _:genid123863 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0002329 obo:IAO_0000115 "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." ; obo:IAO_0000116 "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" ; obo:UBPROP_0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]", "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO]", "relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO]", "relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO]" ; obo:UBPROP_0000003 "(...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG]" ; obo:UBPROP_0000007 "somitic" ; oboInOwl:hasBroadSynonym "mesodermal cluster" ; oboInOwl:hasDbXref "AAO:0010569", "AEO:0001015", "BTO:0001558", "EHDAA2:0003436", "EHDAA:366", "EHDAA:699", "EMAPA:31169", "FMA:85522", "GAID:1306", "MAT:0000068", "MESH:D019170", "MIAA:0000068", "NCIT:C34302", "TAO:0000155", "UMLS:C0376449", "VHOG:0000191", "Wikipedia:Somite", "XAO:0000058", "ZFA:0000155" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epimere", "epimere mesoderm", "epithelial somite", "somites", "somitic mesoderm", "somitus" ; oboInOwl:id "UBERON:0002329" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]" ; rdfs:label "somite" ; rdfs:subClassOf obo:UBERON_0005423, obo:UBERON_0007503, _:genid123877 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0002330 obo:IAO_0000115 "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." ; oboInOwl:hasDbXref "CALOHA:TS-2057", "EHDAA2:0002225", "EMAPA:35329", "FMA:85539", "MA:0002411", "NCIT:C12957", "UMLS:C1516995", "Wikipedia:Exocrine_gland", "WikipediaCategory:Exocrine_system" ; oboInOwl:hasExactSynonym "exocrine glandular system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002330" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "exocrine system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002365 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0002390, obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002331 obo:IAO_0000115 "The connecting cord from the developing embryo to the placenta." ; obo:UBPROP_0000001 "The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP]." ; obo:UBPROP_0000007 "umbilical" ; oboInOwl:hasDbXref "BTO:0001415", "CALOHA:TS-1078", "EFO:0001415", "EHDAA2:0000312", "EHDAA:158", "EMAPA:26115", "EV:0100127", "FMA:85541", "GAID:517", "MAT:0000280", "MESH:D014470", "MIAA:0000280", "NCIT:C34320", "SCTID:280644003", "UMLS:C0041633", "Wikipedia:Umbilical_cord" ; oboInOwl:hasExactSynonym "chorda umbilicalis", "funiculus umbilicalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "birth cord", "connecting stalk", "funiculus umbilicalis", "yolk stalk" ; oboInOwl:id "UBERON:0002331" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "See notes for connecting stalk" ; rdfs:label "umbilical cord" ; rdfs:subClassOf obo:UBERON_0000478, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001987 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007806 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Umbilicalcord.jpg"^^xsd:anyURI . obo:UBERON_0002333 obo:IAO_0000115 "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." ; obo:UBPROP_0000001 "An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG]" ; obo:UBPROP_0000003 "As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001576", "EHDAA:9831", "EMAPA:17015", "FMA:8612", "MA:0002033", "NCIT:C116918", "VHOG:0001134", "galen:PulmonaryTrunk" ; oboInOwl:hasExactSynonym "pulmonary artery (trunk)", "trunk of pulmonary arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "main pulmonary artery" ; oboInOwl:id "UBERON:0002333" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pulmonary trunk" ; rdfs:subClassOf obo:UBERON_0001637, _:genid123063, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002080 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png"^^xsd:anyURI . obo:UBERON_0002334 obo:IAO_0000115 "The duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue." ; obo:UBPROP_0000012 "FMA also has 'main submandibular duct' (FMA:59899)" ; oboInOwl:hasDbXref "BTO:0004556", "EMAPA:35833", "FMA:86266", "MA:0002698", "NCIT:C33649", "SCTID:181237009", "UMLS:C0227472", "Wikipedia:Submandibular_duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Wharton's duct", "ductus submandibularis", "ductus submaxillaris", "submandibular salivary duct", "submaxillar gland duct", "submaxillary duct" ; oboInOwl:id "UBERON:0002334" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "submandibular duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001736 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001736 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001837 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001736 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png"^^xsd:anyURI . obo:UBERON_0002336 obo:IAO_0000115 "White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres.it is subdivided into a genu, a rostrum, a body, and a splenium. (MM)." ; obo:UBPROP_0000001 "The largest commissure of the brain connecting the cerebral hemispheres. [TFD][VHOG]" ; obo:UBPROP_0000003 "In addition to the anterior commissure, placental mammals have a phylogenetically new forebrain commissure, the corpus callosum, which primarily interconnects the neocortex of the cerebral hemispheres.[well established][VHOG]" ; obo:UBPROP_0000008 "The corpus callosum is found only in placental mammals. other groups do have other brain structures that allow for communication between the two hemispheres, such as the anterior commissure, which serves as the primary mode of interhemispheric communication in marsupials." ; oboInOwl:hasDbXref "BAMS:CC", "BAMS:cc", "BIRNLEX:1087", "BM:Tel-CC", "BTO:0000615", "CALOHA:TS-0180", "DHBA:10561", "EFO:0001390", "EMAPA:35253", "EV:0100305", "FMA:86464", "GAID:683", "HBA:9222", "MA:0000188", "MAT:0000286", "MBA:776", "MESH:D003337", "MIAA:0000286", "NCIT:C12446", "SCTID:362354006", "UMLS:C0010090", "VHOG:0001608", "Wikipedia:Corpus_callosum", "neuronames:191" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002336" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "corpus callosum" ; rdfs:subClassOf obo:UBERON_0002473, obo:UBERON_0005340, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001893 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray733.png"^^xsd:anyURI . obo:UBERON_0002337 obo:IAO_0000115 "The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle." ; oboInOwl:hasDbXref "CALOHA:TS-1266", "EMAPA:35310", "FMA:86487", "MA:0002734", "NCIT:C32516", "SCTID:254115004", "UMLS:C0227849" ; oboInOwl:hasExactSynonym "endometrium stroma", "stroma of endometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002337" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endometrial stroma" ; owl:equivalentClass _:genid123092 . obo:UBERON_0002338 obo:IAO_0000115 "A lamina propria that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35194", "FMA:86619", "MA:0001836", "NCIT:C49212", "UMLS:C1707054" ; oboInOwl:hasExactSynonym "bronchi lamina propria", "bronchi lamina propria mucosa", "bronchi lamina propria mucosae", "bronchial trunk lamina propria", "bronchial trunk lamina propria mucosa", "bronchial trunk lamina propria mucosae", "bronchus lamina propria", "bronchus lamina propria mucosa", "bronchus lamina propria mucosae", "lamina propria mucosa of bronchi", "lamina propria mucosa of bronchial trunk", "lamina propria mucosa of bronchus", "lamina propria mucosae of bronchi", "lamina propria mucosae of bronchial trunk", "lamina propria mucosae of bronchus", "lamina propria of bronchi", "lamina propria of bronchial trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchial lamina propria" ; oboInOwl:id "UBERON:0002338" ; a owl:Class ; rdfs:label "lamina propria of bronchus" ; rdfs:subClassOf obo:UBERON_0000030, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ], _:genid123947 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0002342 obo:IAO_0000115 "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." ; obo:IAO_0000116 "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." ; obo:RO_0002174 obo:NCBITaxon_117565 ; obo:UBPROP_0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]", "Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO]" ; obo:UBPROP_0000003 "A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831]", "We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010578", "BTO:0001764", "CALOHA:TS-0676", "EHDAA2:0004419", "EMAPA:32737", "FMA:86666", "GAID:1310", "MAT:0000066", "MESH:D009432", "MIAA:0000066", "NCIT:C34222", "SCTID:361462002", "TAO:0000045", "UMLS:C0027789", "VHOG:0000057", "Wikipedia:Neural_crest", "XAO:0000048", "ZFA:0000045", "neuronames:1366" ; oboInOwl:hasExactSynonym "NC" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crista neuralis", "neural crest material" ; oboInOwl:id "UBERON:0002342" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells." ; rdfs:label "neural crest" ; rdfs:subClassOf obo:UBERON_0010316, _:genid123969, _:genid123971, _:genid123973, _:genid123975, _:genid123977 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png"^^xsd:anyURI . obo:UBERON_0002343 obo:IAO_0000115 "Set of all muscles in abdomen." ; obo:IAO_0000232 "distinction between abdomen muscle and abdomen musculature" ; oboInOwl:hasDbXref "FMA:71294", "FMA:86917", "TAO:0001327", "ZFA:0001327" ; oboInOwl:hasExactSynonym "abdominal musculature", "muscle group of abdomen", "muscles of abdomen", "musculature of abdomen", "musculature of abdominal wall", "set of muscles of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002343" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "abdomen musculature" ; rdfs:subClassOf obo:UBERON_0001015 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0002345 obo:IAO_0000115 "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." ; oboInOwl:hasDbXref "EFO:0002527", "EMAPA:18605", "FMA:87217", "MA:0002572", "SCTID:181301002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002345" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "descending thoracic aorta" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001514 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001514 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001515 ] . obo:UBERON_0002346 obo:IAO_0000115 "Embryonic ectoderm that gives rise to nervous tissue." ; obo:UBPROP_0000003 "(...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG]" ; obo:UBPROP_0000007 "neurectodermal" ; obo:UBPROP_0000013 "we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here" ; oboInOwl:hasDbXref "AAO:0011074", "BILA:0000039", "CALOHA:TS-1212", "EHDAA2:0001248", "EHDAA:1498", "EHDAA:255", "EMAPA:16073", "EV:0100004", "FBbt:00001057", "FMA:87657", "MAT:0000176", "MIAA:0000176", "NCIT:C34228", "TAO:0001120", "UMLS:C1518271", "VHOG:0000150", "Wikipedia:Neuroectoderm", "XAO:0000042", "ZFA:0001120" ; oboInOwl:hasExactSynonym "neural ectoderm", "neuroectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium tubi neuralis; neuroectoderma", "neuaral ectoderm", "presumptive central nervous system", "ventral neurogenic region" ; oboInOwl:id "UBERON:0002346" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neurectoderm" ; rdfs:subClassOf obo:UBERON_0000923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000133 ], _:genid124004 . obo:UBERON_0002347 obo:IAO_0000115 "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." ; obo:UBPROP_0000008 "Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, they are distinguished by the presence of facets on the sides of the bodies for articulation with the heads of the ribs, and facets on the transverse processes of all, except the eleventh and twelfth, for articulation with the tubercles of the ribs" ; oboInOwl:hasDbXref "EMAPA:18011", "FMA:9139", "GAID:244", "MA:0000314", "MESH:D013904", "NCIT:C12798", "SCTID:181821009", "UMLS:C0039987", "Wikipedia:Thoracic_vertebrae" ; oboInOwl:hasExactSynonym "dorsal vertebra", "thorax vertebra", "vertebra of thorax", "vertebra thoracica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002347" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "thoracic vertebra" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013507 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015008 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png"^^xsd:anyURI . obo:UBERON_0002348 obo:IAO_0000115 "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." ; obo:IAO_0000116 "TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer." ; obo:UBPROP_0000001 "External layer of the heart.[TAO]", "The inner layer of the pericardium that is in contact with the surface of the heart.[AAO]" ; obo:UBPROP_0000009 "The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium]" ; oboInOwl:hasDbXref "AAO:0010409", "EHDAA2:0002202", "FMA:9461", "NCIT:C13164", "TAO:0005057", "UMLS:C0225968", "VHOG:0000119", "Wikipedia:Epicardium", "XAO:0000316", "ZFA:0005057", "galen:Epicardium" ; oboInOwl:hasExactSynonym "heart epicardium", "visceral serous pericardium of heart", "visceral serous pericardium proper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pericardium visceral mesothelium" ; oboInOwl:id "UBERON:0002348" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "epicardium" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004160 ], _:genid124021, _:genid124023, _:genid124026 . obo:UBERON_0002349 obo:IAO_0000115 "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." ; obo:IAO_0000116 "TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium" ; obo:UBPROP_0000001 "Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]", "The middle layer of the heart, consisting of cardiac muscle.[AAO]" ; obo:UBPROP_0000007 "myocardial" ; oboInOwl:hasDbXref "AAO:0010410", "BSA:0000089", "BTO:0000901", "CALOHA:TS-0440", "EFO:0000819", "EHDAA2:0004150", "EMAPA:32688", "EV:0100022", "FMA:9462", "GAID:173", "MA:0000164", "MAT:0000453", "MESH:D009206", "NCIT:C12371", "RETIRED_EHDAA2:0001220", "SCTID:362012001", "TAO:0001319", "UMLS:C0027061", "VHOG:0000083", "Wikipedia:Myocardium", "XAO:0000065", "ZFA:0001319", "galen:Myocardium" ; oboInOwl:hasExactSynonym "heart myocardium", "muscle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac muscle", "heart muscle" ; oboInOwl:id "UBERON:0002349" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "myocardium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000383 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], _:genid123186 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005983 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001133 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg"^^xsd:anyURI . obo:UBERON_0002350 obo:IAO_0000115 "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." ; obo:IAO_0000116 "EHDAA2 divides the system from the tissue" ; obo:UBPROP_0000003 "The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EFO:0003909", "EHDAA2:0004185", "EMAPA:35428", "EV:0100025", "FMA:9476", "MA:0000094", "MESH:D006329", "SCTID:281489000", "TAO:0005063", "VHOG:0001271", "ZFA:0005063" ; oboInOwl:hasExactSynonym "cardiac conducting system", "cardiac conduction system", "cardiac impulse conducting system", "cardionector", "complexus stimulans cordis", "heart conduction system", "impulse conducting system", "systema conducente cordis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "central conduction system" ; oboInOwl:id "UBERON:0002350" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "conducting system of heart" ; rdfs:subClassOf obo:UBERON_0010131, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ], _:genid124050, _:genid124052, _:genid124054, _:genid124056, _:genid124058, _:genid124060 . obo:UBERON_0002351 obo:IAO_0000115 "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." ; oboInOwl:hasDbXref "BTO:0004358", "EHDAA2:0004184", "EMAPA:35772", "FMA:9477", "GAID:561", "MA:0000097", "MESH:D012849", "NCIT:C33555", "SCTID:277687007", "TAO:0005069", "UMLS:C0037189", "Wikipedia:Sinoatrial_node", "ZFA:0005069" ; oboInOwl:hasExactSynonym "Koch's node", "SA nodal muscle tissue", "SA node", "cardiac pacemaker", "node of Keith-Flack", "nodus sinuatrialis", "sinoatrial node", "sinu-atrial node", "sinuatrial nodal muscle tissue", "sinuatrial node", "sinus node", "sinus node of Keith and Flack" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nodus sinuatrialis" ; oboInOwl:id "UBERON:0002351" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "WP:Heart states: \"The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.\". Note however that ZFA has SA node." ; rdfs:label "sinoatrial node" ; rdfs:subClassOf obo:UBERON_0010131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002027 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0060048 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002350 ], _:genid124073 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg"^^xsd:anyURI . obo:UBERON_0002352 obo:IAO_0000115 "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." ; obo:UBPROP_0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG]" ; oboInOwl:hasDbXref "BTO:0005689", "EFO:0000276", "EHDAA2:0004183", "EMAPA:35153", "FMA:9478", "GAID:558", "MA:0000095", "MAT:0000498", "MESH:D001283", "NCIT:C32161", "SCTID:277688002", "TAO:0005070", "UMLS:C0004247", "VHOG:0001474", "Wikipedia:Atrioventricular_node", "ZFA:0005070" ; oboInOwl:hasExactSynonym "AV nodal muscle tissue", "AV node", "Aschoff-Tawara node", "atrioventricular nodal muscle tissue", "node of Tawara", "nodus atrioventricularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "A-V node", "atrio-ventricular node", "atriovetricular node", "downstream pacemaker", "nodus atrioventricularis" ; oboInOwl:id "UBERON:0002352" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "atrioventricular node" ; rdfs:subClassOf obo:UBERON_0010131, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002085 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002350 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002085 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0005979 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002350 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png"^^xsd:anyURI . obo:UBERON_0002355 obo:IAO_0000115 "The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs." ; obo:UBPROP_0000007 "pelvic" ; obo:UBPROP_0000012 "MA and FMA differ in what they consider to be parts of the pelvis. MA includes ureter, urethra, urinary bladder, reproductive organs" ; oboInOwl:hasDbXref "BTO:0001006", "CALOHA:TS-2227", "EFO:0002805", "EMAPA:35931", "EV:0100012", "FMA:9578", "GAID:87", "MA:0000030", "MESH:D010388", "NCIT:C12767", "SCTID:229765004", "UMLS:C0030797", "Wikipedia:Pelvis", "galen:Pelvis" ; oboInOwl:hasExactSynonym "lesser pelvis", "pelvic region", "pelvis", "pelvis region", "true pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002355" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pelvic region of trunk" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007832 ] . obo:UBERON_0002356 obo:IAO_0000115 "Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, abdomen, and pelvis, it constitutes the trunk[FMA]." ; obo:UBPROP_0000007 "perianal" ; obo:UBPROP_0000012 "FMA has class anal part of perineum, which may be the same as what EHDAA2 calls perineum" ; oboInOwl:hasDbXref "EFO:0004141", "EHDAA2:0004015", "EMAPA:36628", "EV:0100013", "FMA:9579", "GAID:90", "MA:0002466", "MESH:D010502", "NCIT:C33301", "SCTID:243990009", "UMLS:C0031066", "Wikipedia:Perineum", "galen:Perineum" ; oboInOwl:hasExactSynonym "perineal region", "regio perinealis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002356" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "perineum" ; rdfs:subClassOf obo:UBERON_0009569, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ], _:genid124123 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray406.png"^^xsd:anyURI . obo:UBERON_0002357 obo:IAO_0000115 "Serous membrane which is divided into parietal and visceral serous pericardium." ; oboInOwl:hasDbXref "EMAPA:19030", "FMA:9582", "MA:0002739", "SCTID:243954002", "Wikipedia:Serous_pericardium" ; oboInOwl:hasExactSynonym "serous portion of pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pericardium serosum" ; oboInOwl:id "UBERON:0002357" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "serous pericardium" ; rdfs:subClassOf obo:UBERON_0000042, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002408 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002425 ], _:genid124129, _:genid124133 . obo:UBERON_0002358 obo:IAO_0000115 "A serous membrane that lines the peritoneal cavity[VHOG,modified]." ; obo:IAO_0000116 "TODO - in ZFA is_a epithelium" ; obo:UBPROP_0000001 "An epithelium that lines the peritoneal cavity.[TAO]", "Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]" ; obo:UBPROP_0000007 "peritoneal" ; obo:UBPROP_0000012 "todo: check MA/EMAPA." ; oboInOwl:hasDbXref "AAO:0010814", "BTO:0001472", "CALOHA:TS-2072", "EV:0100087", "FMA:9584", "GAID:18", "MA:0000449", "MESH:D010537", "NCIT:C12770", "TAO:0005120", "UMLS:C0031153", "VHOG:0001257", "Wikipedia:Peritoneum", "XAO:0000139", "ZFA:0005120", "galen:Peritoneum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "peritonaeum" ; oboInOwl:id "UBERON:0002358" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "peritoneum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ], _:genid124142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035820 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png"^^xsd:anyURI . obo:UBERON_0002359 obo:IAO_0000115 "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." ; obo:UBPROP_0000010 "most superficial part of pericardium; continuous with the outer adventitial layer of the neighboring great blood vessels. [Wikipedia:Pericardium]" ; oboInOwl:hasDbXref "EMAPA:19029", "FMA:9586", "MA:0002738", "SCTID:243953008", "Wikipedia:Fibrous_pericardium" ; oboInOwl:hasExactSynonym "fibrous portion of pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pericardium fibrosum" ; oboInOwl:id "UBERON:0002359" ; oboInOwl:inSubset core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:label "fibrous pericardium" ; rdfs:subClassOf obo:UBERON_0000094, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002408 ], _:genid124152, _:genid124155 . obo:UBERON_0002360 obo:IAO_0000115 "Membrane organ that surrounds the brain and the spinal cord." ; obo:UBPROP_0000001 "Membrane covering the brain and spinal cord. It is represented by a single layer in fishes, two in amphibians, reptiles and birds and three in mammals (named dura mater, arachnoid and pia mater). [TFD][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; obo:UBPROP_0000007 "meningeal" ; obo:UBPROP_0000008 "Whereas cyclostomes and fishes only have a single envelope called the primitive meninx, amphibians have two layers, consisting of an outer dura mater which is extremely dense and protective, and a pia-arachnoid or secondary meninx which is more delicate and vascular. Mammals have three meninges: pia mater (which follows all the convolutions of the brain and is the most interior), the arachnoid layer (which is delicate and sends strands to the pia mater), and the dura mater (the outer, more protective meninx)." ; obo:UBPROP_0000012 "Not consider part of the CNS/neuraxis in FMA" ; obo:UBPROP_0000202 obo:FMA_76821 ; oboInOwl:hasDbXref "BTO:0000144", "CALOHA:TS-1177", "EFO:0000867", "EMAPA:32660", "EV:0100312", "FMA:9589", "GAID:687", "MA:0001113", "MAT:0000113", "MESH:D008578", "NCIT:C12348", "NLXANAT:090204", "TAO:0001355", "UMLS:C0025285", "VHOG:0001295", "Wikipedia:Meninx", "ZFA:0001355" ; oboInOwl:hasExactSynonym "layer of meninges", "meningeal layer" ; oboInOwl:hasNarrowSynonym "meninx primitiva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002360" ; oboInOwl:inSubset core:efo_slim, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "meninx" ; rdfs:subClassOf obo:UBERON_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010743 ], _:genid123292, _:genid124162 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg"^^xsd:anyURI . obo:UBERON_0002361 obo:IAO_0000115 "The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals." ; obo:IAO_0000116 "consider adding adjacency relationship to neuraxis (brain+spinal cord); however note that at this time the meninges may be considered part of the nervous system" ; obo:UBPROP_0000001 "delicate innermost layer of the meninges-the membranes surrounding the brain and spinal cord. The thin, mesh-like pia mater closely envelops the entire surface of the brain, running down into the fissures of the cortex. It joins with the ependyma which lines the ventricles to form choroid plexuses that produce cerebrospinal fluid. In the spinal cord, the pia mater attaches to the dura mater by the denticular ligaments through the arachnoid membrane. The pia mater is a neural crest derivative[Wikipedia:Pia_mater]." ; oboInOwl:hasDbXref "BTO:0001635", "EHDAA2:0004318", "EHDAA:1367", "EHDAA:1961", "EHDAA:2001", "EHDAA:2099", "EHDAA:2685", "EHDAA:2833", "EHDAA:2867", "EHDAA:3692", "EHDAA:3710", "EHDAA:6566", "EHDAA:6583", "EMAPA:32663", "EV:0100315", "FMA:9590", "GAID:693", "MA:0001116", "MESH:D010841", "NCIT:C33321", "NLXANAT:090209", "RETIRED_EHDAA2:0001464", "SCTID:362305004", "UMLS:C0031869", "Wikipedia:Pia_mater", "neuronames:1463" ; oboInOwl:hasExactSynonym "pia mater of neuraxis", "pial membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pia" ; oboInOwl:id "UBERON:0002361" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pia mater" ; rdfs:subClassOf obo:UBERON_0000391, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011825 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray770-en.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray770.png"^^xsd:anyURI . obo:UBERON_0002362 obo:IAO_0000115 "A think avascular meningeal layer, between the pia mater and the dural mater. It is separated from the pia mater by the subarachnoid space." ; obo:RO_0002171 obo:UBERON_0002049 ; oboInOwl:hasDbXref "BTO:0001636", "CALOHA:TS-0052", "EMAPA:32659", "EV:0100314", "FMA:9591", "GAID:688", "MA:0001114", "MESH:D001099", "NCIT:C32136", "NLXANAT:090208", "SCTID:362304000", "UMLS:C1510935", "Wikipedia:Arachnoid_mater", "neuronames:1464" ; oboInOwl:hasExactSynonym "arachnoid", "arachnoid mater of neuraxis", "arachnoid membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arachnoidea mater" ; oboInOwl:id "UBERON:0002362" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "arachnoid mater" ; rdfs:subClassOf obo:UBERON_0000391, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0071953 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a0/Gray767.png"^^xsd:anyURI . obo:UBERON_0002363 obo:IAO_0000115 "Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections." ; obo:UBPROP_0000001 "the outermost of the three layers of the meninges surrounding the brain and spinal cord. The other two meningeal layers are the pia mater and the arachnoid mater. The dura surrounds the brain and the spinal cord and is responsible for keeping in the cerebrospinal fluid[Wikipedia:Dura_mater]." ; obo:UBPROP_0000009 "capable of inducing chondrogenesis - requires contact with an epithelium - http://www.ncbi.nlm.nih.gov/pubmed/16496288" ; obo:UBPROP_0000012 "some ontologies consider dura mater part of the CNS, others dispute this and claim it surrounds it (e.g. DOI:10.1111/joa.12381)[https://github.com/obophenotype/uberon/issues/1261]" ; oboInOwl:hasDbXref "BTO:0001637", "CALOHA:TS-2008", "EMAPA:32664", "EV:0100313", "FMA:9592", "GAID:691", "MA:0001115", "MESH:D004388", "NCIT:C32488", "NLXANAT:090206", "SCTID:362301008", "UMLS:C0013313", "Wikipedia:Dura_mater", "neuronames:1462" ; oboInOwl:hasExactSynonym "dura mater of neuraxis", "pachymeninges" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dura" ; oboInOwl:id "UBERON:0002363" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "dura mater" ; rdfs:subClassOf obo:UBERON_0002360, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011823 ], _:genid124182, _:genid124185 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Meninges-en.svg"^^xsd:anyURI . obo:UBERON_0002364 obo:IAO_0000115 "A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted]." ; obo:UBPROP_0000001 "The thin membrane which closes externally the cavity of the middle ear and is deeply sited at the bottom of the external auditory meatus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "In particular, a tympanic membrane was not present in the earliest tetrapods (...). An ear utilizing a tympanic membrane evolved independently at least three times in tetrapods: (1) in the lineage that leads to anurans (frogs), (2) in the line of evolution to turtles and diapsids, and (3) in the late synapsid lineage that gave rise to mammals.[well established][VHOG]" ; obo:UBPROP_0000011 "The tympanic membrane (TM) has three layers, two epithelia provided by the external acoustic meatus (EAM) and the MEC, derived respectively from the first pharyngeal cleft and pouch, and a mesenchymally derived fibrous stratum" ; obo:UBPROP_0000012 "most AOs consider this part of the middle ear, so we go with this and place it in the middle ear as a border to the external, although it could be considered to overlap the external ear in that it has an EAM layer as part - for this reason we do not consider middle and external ear to be spatially disjoint." ; oboInOwl:hasDbXref "EMAPA:19062", "FMA:9595", "GAID:870", "MA:0000257", "MESH:D014432", "NCIT:C12502", "SCTID:181180005", "UMLS:C0041445", "VHOG:0001146", "Wikipedia:Tympanic_membrane", "XAO:0000212" ; oboInOwl:hasExactSynonym "Rivinus' membrane", "ear drum", "eardrum", "lateral wall of tympanic cavity", "membranous wall of tympanic cavity", "myrinx", "paries membranaceus cavi tympani" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tympanum" ; oboInOwl:id "UBERON:0002364" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tympanic membrane" ; rdfs:subClassOf obo:UBERON_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005042 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010069 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010070 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001352 ], _:genid123325, _:genid124193, _:genid124199, _:genid124201, _:genid124203 . obo:UBERON_0002365 obo:IAO_0000115 "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." ; obo:IAO_0000116 "Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses" ; oboInOwl:hasDbXref "AEO:0000097", "BTO:0000765", "CALOHA:TS-2012", "EHDAA2:0003097", "EMAPA:35327", "FMA:9596", "GAID:34", "MA:0002564", "MESH:D005088", "NCIT:C12712", "SCTID:115976003", "UMLS:C0015282", "Wikipedia:Exocrine_gland" ; oboInOwl:hasExactSynonym "ducted gland", "glandula exocrina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002365" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "exocrine gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000058 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ] ) ] . obo:UBERON_0002367 obo:IAO_0000115 "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." ; obo:IAO_0000116 "TODO - FMA treats the gland as part of the prostate - see also FMA:74119." ; obo:UBPROP_0000007 "prostatic" ; oboInOwl:hasDbXref "BTO:0001129", "CALOHA:TS-0828", "EFO:0000858", "EMAPA:19287", "EV:0100104", "FMA:9600", "GAID:392", "MA:0000404", "MAT:0000078", "MESH:D011467", "MIAA:0000078", "NCIT:C12410", "SCTID:181422007", "UMLS:C0033572", "VHOG:0001261", "Wikipedia:Prostate", "galen:ProstateGland" ; oboInOwl:hasExactSynonym "male prostate", "prostate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prostata" ; oboInOwl:id "UBERON:0002367" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "prostate gland" ; rdfs:subClassOf obo:UBERON_0010147, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003820 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg"^^xsd:anyURI . obo:UBERON_0002368 obo:IAO_0000115 "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." ; oboInOwl:hasDbXref "AEO:0000098", "BTO:0001488", "CALOHA:TS-1300", "EHDAA2:0003098", "EMAPA:35999", "FMA:9602", "GAID:335", "MA:0002563", "MESH:D004702", "NCIT:C12704", "SCTID:40818001", "UMLS:C0014133", "Wikipedia:Endocrine_gland" ; oboInOwl:hasExactSynonym "ductless gland", "glandula endocrina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductless gland", "glandulae endocrinae" ; oboInOwl:id "UBERON:0002368" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "endocrine gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png"^^xsd:anyURI . obo:UBERON_0002369 obo:IAO_0000115 "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." ; obo:UBPROP_0000001 "Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]" ; obo:UBPROP_0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" ; obo:UBPROP_0000008 "The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole" ; obo:UBPROP_0000009 "suprarenal cortex manufactures corticosteroids; suprarenal medulla manufactures epinephrine and norepinephrine; suprarenal medulla receives preganglionic sympathetic innervation from the greater thoracic splanchnic n." ; oboInOwl:hasDbXref "AAO:0010551", "BTO:0000047", "CALOHA:TS-0016", "EFO:0000238", "EMAPA:18426", "EV:0100135", "FMA:9604", "GAID:446", "MA:0000116", "MAT:0000071", "MESH:D000311", "MIAA:0000071", "NCIT:C12666", "SCTID:181127006", "UMLS:C0001625", "VHOG:0001141", "Wikipedia:Adrenal_gland", "XAO:0000164", "galen:AdrenalGland" ; oboInOwl:hasExactSynonym "glandula adrenalis", "glandula suprarenalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal", "adrenal capsule", "adrenal medulla cell", "atrabiliary capsule", "epinephric gland", "epinephros", "glandula suprarenalis", "interrenal gland", "suprarenal capsule", "suprarenal gland" ; oboInOwl:id "UBERON:0002369" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "adrenal gland" ; rdfs:subClassOf obo:UBERON_0006858, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ], _:genid124239, _:genid124241, _:genid124243 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg"^^xsd:anyURI . obo:UBERON_0002370 obo:IAO_0000115 "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." ; obo:IAO_0000116 "check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland." ; obo:UBPROP_0000001 "Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO]" ; obo:UBPROP_0000003 "A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG]" ; obo:UBPROP_0000007 "thymic" ; oboInOwl:hasDbXref "AAO:0010548", "BTO:0001374", "CALOHA:TS-1043", "EFO:0000860", "EHDAA2:0002017", "EHDAA:9119", "EMAPA:18768", "EV:0100138", "FMA:9607", "GAID:464", "MA:0000142", "MAT:0000080", "MESH:D013950", "MIAA:0000080", "NCIT:C12433", "SCTID:118507000", "TAO:0001078", "UMLS:C0040113", "VHOG:0000253", "Wikipedia:Thymus", "XAO:0000163", "ZFA:0001078" ; oboInOwl:hasExactSynonym "thymus gland", "thymus organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002370" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:organ_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "thymus" ; rdfs:subClassOf obo:UBERON_0002368, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003483 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003846 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0030217 ], _:genid124262, _:genid124264, _:genid124266, _:genid124271 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg"^^xsd:anyURI . obo:UBERON_0002371 obo:IAO_0000115 "The soft tissue that fills the cavities of bones." ; obo:IAO_0000116 "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs", "consider placement of NCIT:C53466 medullary bone" ; obo:UBPROP_0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" ; obo:UBPROP_0000009 "In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow]" ; oboInOwl:hasDbXref "AAO:0011007", "BTO:0000141", "BTO:0000829", "CALOHA:TS-0087", "EFO:0000868", "EMAPA:32760", "EV:0100046", "FMA:9608", "GAID:1287", "MA:0000134", "MAT:0000084", "MESH:D001853", "MIAA:0000084", "NCIT:C12431", "SCTID:421320006", "UMLS:C0005953", "VHOG:0001218", "Wikipedia:Bone_marrow", "XAO:0000123", "galen:BoneMarrow" ; oboInOwl:hasExactSynonym "medulla ossea", "medulla ossium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medulla of bone", "medullary bone" ; oboInOwl:id "UBERON:0002371" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "bone marrow" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002092 ], _:genid124283 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0012429 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg"^^xsd:anyURI . obo:UBERON_0002372 obo:IAO_0000115 "Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx." ; obo:IAO_0000232 "the term 'tonsil' can be ambiguous, sometimes refering specifically to the palatine tonsil, sometimes generically to include the cecal tonsils of avians. This class represents lymphoid tissue that is part of the tonsillar ring, in the mouth/throat region" ; oboInOwl:hasDbXref "BTO:0001387", "CALOHA:TS-1053", "EFO:0001401", "EMAPA:35871", "EV:0100052", "FMA:9609", "GAID:341", "MA:0000143", "MESH:D014066", "NCIT:C12802", "UMLS:C0836921", "UMLS:C1519547", "UMLS:C1519548", "VHOG:0001139", "Wikipedia:Tonsil", "neuronames:671" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Mandel" ; oboInOwl:id "UBERON:0002372" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tonsil" ; rdfs:subClassOf obo:UBERON_0001961, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001735 ], _:genid124294 . obo:UBERON_0002374 obo:IAO_0000115 "A bone that is part of the metacarpal skeleton." ; oboInOwl:hasDbXref "EFO:0003886", "EMAPA:36158", "FMA:9612", "MA:0000302", "NCIT:C12751", "SCTID:181977005", "SCTID:425761003", "UMLS:C0025526", "Wikipedia:Metacarpal_bone", "galen:Metacarpal" ; oboInOwl:hasExactSynonym "metacarpal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002374" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "metacarpal bone" ; rdfs:subClassOf obo:UBERON_0003821, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010544 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001435 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001436 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004453 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg"^^xsd:anyURI . obo:UBERON_0002375 obo:IAO_0000115 "A cartilaginous ring that provides support for the arytenoid cartilages and forms the caudal part of the larynx." ; obo:UBPROP_0000001 "Cartilaginous ring that provides support for the arytenoid cartilages. Its ventral part is bent posteriorly to form a V.[AAO]", "The ringlike cartilage forming the caudal part of the larynx. [TFD][VHOG]" ; obo:UBPROP_0000003 "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000675", "EHDAA2:0000326", "EHDAA:9393", "EMAPA:18696", "FMA:9615", "GAID:110", "MA:0001762", "MESH:D003413", "NCIT:C32400", "SCTID:263484006", "UMLS:C0010323", "VHOG:0001308", "Wikipedia:Cricoid_cartilage" ; oboInOwl:hasExactSynonym "cartilago cricoidea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilaginis cricoideae", "cartilago cricoidea", "cartilago cricotrachealis", "cricoid", "cricoidea", "innominate cartilage", "krykoid cartilage" ; oboInOwl:id "UBERON:0002375" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cricoid cartilage" ; rdfs:subClassOf obo:UBERON_0001739, _:genid124314, _:genid124316 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/Gray1194.png"^^xsd:anyURI . obo:UBERON_0002376 obo:IAO_0000115 "Any skeletal muscle that is part of the head region." ; oboInOwl:hasAlternativeId "UBERON:0003899" ; oboInOwl:hasDbXref "AAO:0000107", "BTO:0000021", "EFO:0003524", "EHDAA2:0000322", "EMAPA:18172", "FMA:9616", "MA:0000578", "SCTID:244718003", "ZFA:0001652" ; oboInOwl:hasExactSynonym "cephalic muscle", "cephalic musculature", "head muscle", "head muscle organ", "muscle of head", "muscle organ of adult head", "muscle organ of head", "musculus caput" ; oboInOwl:hasNarrowSynonym "adult head muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial muscle", "head muscles" ; oboInOwl:id "UBERON:0002376" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984)" ; rdfs:label "cranial muscle" ; rdfs:subClassOf obo:UBERON_0010959, _:genid124337, _:genid124339 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:UBERON_0002377 obo:IAO_0000115 "Any muscle that is part of the cervical (neck) region." ; oboInOwl:hasDbXref "EMAPA:36050", "FMA:9617", "GAID:149", "MA:0000587", "MESH:D009334", "NCIT:C33163", "UMLS:C0027532" ; oboInOwl:hasExactSynonym "muscle organ of neck", "muscle organ of neck (volume)", "neck (volume) muscle organ", "neck muscle", "neck muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002377" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "muscle of neck" ; rdfs:subClassOf obo:UBERON_0010959, _:genid124354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0002378 obo:IAO_0000115 "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." ; oboInOwl:hasDbXref "BTO:0001261", "EMAPA:35103", "FMA:9620", "GAID:89", "MA:0000520", "MESH:D000009", "NCIT:C32040", "SCTID:361352008", "UMLS:C0000739", "Wikipedia:Abdominal_muscle" ; oboInOwl:hasExactSynonym "abdomen muscle", "abdomen muscle organ", "abdominal muscle", "abdominal wall muscle", "muscle organ of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal wall musculature" ; oboInOwl:id "UBERON:0002378" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "muscle of abdomen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 ], _:genid124366 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0002379 obo:IAO_0000115 "Any muscle organ that is part of a perineum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36629", "FMA:9623", "MA:0000538", "NCIT:C33300", "UMLS:C0224382" ; oboInOwl:hasExactSynonym "muscle of perineum", "muscle organ of perineal region", "muscle organ of perineum", "perineal region muscle organ", "perineum muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002379" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "perineal muscle" ; rdfs:subClassOf obo:UBERON_0001325, _:genid124378 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002356 ] ) ] . obo:UBERON_0002380 obo:IAO_0000115 "A large superficial muscle that extends longitudinally from the occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula (shoulder blade). Its functions are to move the scapulae and support the arm. The trapezius has three functional regions: the superior region (descending part), which supports the weight of the arm; the intermediate region (transverse part), which retracts the scapulae; and the inferior region (ascending part), which medially rotates and depresses the scapulae. [WP,unvetted]." ; obo:UBPROP_0000003 "The sternomastoid and the three parts of the trapezius are branchiomeric muscles that have secondarily acquired an attachment to the pectoral girdle. They evolved from the fish cucullaris.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18183", "FMA:9626", "MA:0002398", "NCIT:C33809", "SCTID:181740005", "UMLS:C0224361", "VHOG:0000834", "Wikipedia:Trapezius_muscle" ; oboInOwl:hasExactSynonym "trapezius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus trapezius", "spinotrapezius" ; oboInOwl:id "UBERON:0002380" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "trapezius muscle" ; rdfs:subClassOf obo:UBERON_0001482, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010955 ], _:genid124387, _:genid124389, _:genid124391, _:genid124393, _:genid124395, _:genid124397 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/60/Trapezius.png"^^xsd:anyURI . obo:UBERON_0002381 obo:IAO_0000115 "The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0001424", "EHDAA:8311", "EMAPA:18179", "FMA:9627", "MA:0002354", "NCIT:C33284", "SCTID:181624003", "UMLS:C0585574", "VHOG:0000895", "Wikipedia:Pectoralis_major_muscle" ; oboInOwl:hasExactSynonym "pectoralis major muscle", "pectoralis major muscle structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus pectoralis major" ; oboInOwl:id "UBERON:0002381" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pectoralis major" ; rdfs:subClassOf obo:UBERON_0001495, _:genid123507, _:genid124406, _:genid124408, _:genid124410, _:genid124412 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png"^^xsd:anyURI . obo:UBERON_0002382 obo:IAO_0000115 "The rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall of the abdomen. There are two parallel sets of muscles, separated by a midline band of connective tissue called the linea alba (white line). It extends from the pubic symphysis/pubic crest inferiorly to the xiphisternum/xiphoid process and lower costal cartilages (5-7) superiorly. It is contained in the Rectus sheath. The rectus is usually crossed by three fibrous bands licked by the tendinous inscriptions. [WP,modified]." ; obo:UBPROP_0000008 "While the 'sixpack' is by far the most common configuration of the muscle bellies of the rectus, there exist rare anatomic variations which result in the appearance of eight ('eightpack'), ten, or-even rarer-asymmetrically arranged segments. All these variations are functionally equivalent" ; oboInOwl:hasDbXref "AAO:0010789", "EHDAA2:0001595", "EHDAA:8252", "EMAPA:18164", "FMA:9628", "GAID:142", "MA:0002364", "MESH:D017568", "NCIT:C33449", "SCTID:256672008", "UMLS:C0206066", "VHOG:0000863", "Wikipedia:Rectus_abdominis_muscle", "XAO:0004128" ; oboInOwl:hasExactSynonym "m. rectus abdominis", "musculus rectus abdominis", "rectus abdominis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002382" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "rectus abdominis muscle" ; rdfs:subClassOf obo:UBERON_0002378, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0007832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000975 ], _:genid124417, _:genid124419 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/95/Rectus_abdominis.png"^^xsd:anyURI . obo:UBERON_0002384 obo:IAO_0000115 "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." ; obo:UBPROP_0000001 "One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]", "Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]", "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]" ; obo:UBPROP_0000012 "MA also has set of connective tissues" ; oboInOwl:hasDbXref "AAO:0000098", "BTO:0000421", "CALOHA:TS-2009", "EFO:0000952", "EMAPA:35251", "FMA:9640", "GAID:100", "MA:0000011", "MAT:0000301", "MESH:D003238", "MIAA:0000301", "NCIT:C12374", "SCTID:361919005", "TAO:0001641", "UMLS:C0009780", "VSAO:0000017", "XAO:0001017", "ZFA:0001632", "galen:ConnectiveTissue" ; oboInOwl:hasExactSynonym "portion of connective tissue", "textus connectivus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Bindegewebe" ; oboInOwl:id "UBERON:0002384" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "connective tissue" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0031012 ] . obo:UBERON_0002385 obo:IAO_0000115 "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." ; obo:RO_0002171 obo:UBERON_0003714 ; obo:UBPROP_0000001 "One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]" ; oboInOwl:hasDbXref "AAO:0000306", "AEO:0000122", "CALOHA:TS-0642", "EHDAA2:0003122", "EMAPA:32715", "FMA:9641", "MA:0002437", "MESH:D009132", "NCIT:C12435", "SCTID:91727004", "UMLS:C2328219", "Wikipedia:Muscle_tissue", "galen:MuscleTissue" ; oboInOwl:hasExactSynonym "muscular tissue", "portion of muscle tissue", "textus muscularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002385" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach." ; rdfs:label "muscle tissue" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006936 ] ; owl:disjointWith obo:UBERON_0003714 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000187 ] ) ] . obo:UBERON_0002386 obo:IAO_0000115 "The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants." ; obo:UBPROP_0000001 "The middle forelimb region. [Evolution, Fourth_Edition_(2006)_Boston_etc.:_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.321, see_Kardong_KV][VHOG]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group. TODO - add distinct term for skeleton and place AAO class here" ; oboInOwl:hasDbXref "BTO:0001447", "CALOHA:TS-2205", "EFO:0003053", "EHDAA2:0000553", "EHDAA:4172", "EHDAA:6218", "EMAPA:17417", "FMA:9663", "GAID:55", "MA:0000034", "MESH:D005542", "NCIT:C32628", "SCTID:362741001", "UMLS:C0016536", "VHOG:0000341", "VSAO:0005058", "Wikipedia:Forearm", "galen:Forearm" ; oboInOwl:hasExactSynonym "antebrachial region", "antebrachium", "antibrachium", "arm middle limb segment", "arm zeugopod", "brachial region middle limb segment", "brachial region zeugopod", "forearm", "forelimb epipodium", "forelimb zeugopodium", "forelimb zygopod", "intermediate segment of free upper limb", "lower arm", "lower segment of arm", "middle limb segment of arm", "middle limb segment of brachial region", "middle limb segment of forelimb", "middle limb segment of proximal segment of free upper limb", "regio antebrachialis", "zeugopod of arm", "zeugopod of brachial region", "zeugopod of forelimb", "zeugopod of proximal segment of free upper limb" ; oboInOwl:hasNarrowSynonym "wing zeugopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "antebrachium", "fore epipodium" ; oboInOwl:id "UBERON:0002386" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "forelimb zeugopod" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010703 ], _:genid124453 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002471 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png"^^xsd:anyURI . obo:UBERON_0002387 obo:IAO_0000115 "Distal portion of the hind limb, including tarsal region, metatarsal region and digits." ; obo:UBPROP_0000007 "pedal" ; oboInOwl:hasDbXref "BTO:0000476", "CALOHA:TS-0377", "EFO:0003065", "EHDAA2:0000546", "EMAPA:17459", "FMA:9664", "GAID:40", "MA:0000044", "MESH:D005528", "NCIT:C32622", "SCTID:302545001", "UMLS:C0016504", "VHOG:0000350", "Wikipedia:Pes_(anatomy)", "galen:Foot" ; oboInOwl:hasExactSynonym "foot", "hindlimb autopod", "hindlimb autopodium", "hindlimb distal free limb segment", "pes", "terminal segment of free lower limb" ; oboInOwl:hasNarrowSynonym "hind foot", "hind paw", "hind-paw", "hindfeet", "hindfoot", "hindfoot of quadruped", "hindpaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hind limb autopodium" ; oboInOwl:id "UBERON:0002387" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pes" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006871 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001445 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Male_Right_Foot_1.jpg"^^xsd:anyURI . obo:UBERON_0002389 obo:IAO_0000115 "A digit that is part of a manus (hand)." ; obo:UBPROP_0000001 "One of the fingers of the manus.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0000028" ; oboInOwl:hasDbXref "AAO:0000857", "BTO:0004669", "EHDAA2:0000404", "EMAPA:32642", "FMA:9666", "GAID:57", "MA:0000041", "MESH:D005385", "NCIT:C32608", "NLXANAT:20090602", "SCTID:283992002", "UMLS:C0016129", "Wikipedia:Finger", "XAO:0003036", "galen:Finger" ; oboInOwl:hasExactSynonym "digit of hand", "digit of manus", "digitus manus", "finger", "fore digit", "forelimb digit", "hand digit", "manual digit (phalangeal portion) plus soft tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002389" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "manual digit" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5002389 ], _:genid124498 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0002390 obo:IAO_0000115 "Anatomical system that is involved in the production of hematopoietic cells." ; obo:UBPROP_0000001 "Anatomical system that consists of the blood and blood forming tissues.[AAO]" ; obo:UBPROP_0000003 "Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG]" ; obo:UBPROP_0000007 "hematopoietic" ; obo:UBPROP_0000008 "In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes" ; oboInOwl:hasDbXref "AAO:0011002", "BTO:0000570", "CALOHA:TS-0449", "EFO:0000798", "EMAPA:35402", "EV:0100045", "FMA:9667", "GAID:1008", "MA:0002434", "MAT:0000022", "MESH:D006413", "MIAA:0000022", "NCIT:C12909", "SCTID:362587009", "TAO:0005023", "UMLS:C0018957", "VHOG:0001624", "Wikipedia:Haematopoiesis", "XAO:0000122", "ZFA:0005023" ; oboInOwl:hasExactSynonym "haematological system", "haemopoietic system", "organa haemopoietica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Blutbildungssystem", "haematopoietic system", "hematological system", "hematolymphoid system", "hemopoietic system" ; oboInOwl:id "UBERON:0002390" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hematopoietic system" ; rdfs:subClassOf obo:UBERON_0000467, _:genid124509, _:genid124511 ; owl:disjointWith obo:UBERON_0002405, obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002391 obo:IAO_0000115 "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." ; oboInOwl:hasDbXref "BTO:0000855", "CALOHA:TS-0580", "EFO:0000871", "ENVO:02000041", "EV:0100049", "FMA:9671", "GAID:1186", "MA:0002520", "MAT:0000055", "MESH:D008196", "MIAA:0000055", "NCIT:C13252", "UMLS:C0024202", "VHOG:0001590", "Wikipedia:Lymph", "ZFA:0005658", "galen:Lymph" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lympha" ; oboInOwl:id "UBERON:0002391" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lymph" ; rdfs:subClassOf obo:UBERON_0000179, _:genid123612, [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0000913 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Illu_lymph_capillary.png"^^xsd:anyURI . obo:UBERON_0002392 obo:IAO_0000115 "The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity." ; obo:UBPROP_0000003 "The nasolacrimal duct is probably homologous to the posterior (excurrent) naris of actinopterygian fishes.[uncertain][VHOG]" ; obo:UBPROP_0000010 "the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue" ; oboInOwl:hasBroadSynonym "nasolacrimal duct - posterior naris" ; oboInOwl:hasDbXref "AAO:0000643", "EHDAA2:0001237", "EHDAA:7849", "EHDAA:9094", "EMAPA:17853", "FMA:9703", "GAID:902", "MA:0001299", "MESH:D009301", "NCIT:C33161", "SCTID:280643009", "UMLS:C0027437", "VHOG:0000664", "Wikipedia:Nasolacrimal_duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "d. nasolacrimalis", "tear duct" ; oboInOwl:id "UBERON:0002392" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "nasolacrimal duct" ; rdfs:subClassOf obo:UBERON_0000058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000160 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007602 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001351 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006266 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001750 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001827 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png"^^xsd:anyURI . obo:UBERON_0002393 obo:IAO_0000115 "Organ with organ cavity which connects the cavity of the middle ear to the cavity of the pharynx. Examples: There are only two pharyngotympanic tubes, the right and the left pharyngotympanic tubes.[FMA]." ; obo:IAO_0000116 "we follow FMA in making this an organ, but include a separate class for the part that is epithelium, which is equivalent to the EHDAA2 structure. From this we infer the developmental relationship" ; obo:UBPROP_0000001 "Furrow on the ventral surface of the otic capsule, and occasionally also the parasphenoid, that houses the Eustachian tube.[AAO]", "The narrow channel connecting the nasopharynx and the middle ear. [TFD][VHOG]" ; obo:UBPROP_0000002 "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]" ; obo:UBPROP_0000003 "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[uncertain][VHOG]" ; oboInOwl:hasDbXref "AAO:0000146", "AAO:0011016", "EMAPA:17601", "EV:0100359", "FMA:9705", "GAID:869", "MA:0000255", "NCIT:C12500", "UMLS:C0015183", "VHOG:0001145", "Wikipedia:Eustachian_tube", "XAO:0000213" ; oboInOwl:hasExactSynonym "auditory tube", "internal auditory tube", "pharyngo-tympanic tube", "tuba auditiva", "tuba auditoria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eustachian tube", "tuba auditiva; tuba auditoria; tuba auditivea", "tuba pharyngotympanica" ; oboInOwl:id "UBERON:0002393" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pharyngotympanic tube" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010062 ], _:genid124541 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/40/Ear-anatomy-text-small-en.svg"^^xsd:anyURI . obo:UBERON_0002394 obo:IAO_0000115 "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." ; obo:UBPROP_0000001 "A duct that carries bile from the liver to the intestine.", "Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" ; obo:UBPROP_0000012 "we place the ZFA class here as this fits its textual definition and child nodes. We may recommend a label change for ZFA" ; oboInOwl:hasDbXref "AAO:0011019", "BTO:0000122", "CALOHA:TS-0075", "EHDAA2:0000741", "EMAPA:35171", "EV:0100091", "FMA:9706", "GAID:280", "MA:0000354", "MESH:D001652", "NCIT:C12376", "SCTID:276157007", "TAO:0001100", "UMLS:C0005400", "VHOG:0000212", "Wikipedia:Bile_duct", "XAO:0000134", "ZFA:0001100" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bile tube", "biliary duct", "gall duct", "hepatic duct" ; oboInOwl:id "UBERON:0002394" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "bile duct" ; rdfs:subClassOf obo:UBERON_0000058, _:genid123651, [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001970 ], _:genid124559, _:genid124561 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png"^^xsd:anyURI . obo:UBERON_0002395 obo:IAO_0000115 "A proximal tarsal bone resulting from fusion of intermedium and fibulare." ; obo:UBPROP_0000008 "The talus is apparently derived from the fusion of three separate bones in the feet of primitive amphibians; the tibiale, articulating with tibia, the intermedium, between the bases of the tibia and fibula, and the fourth centrale, lying in the mid-part of the tarsus. These bones are still partially separate in modern amphibians, which therefore do not have a true talus. The talus forms a considerably more flexible joint in mammals than it does in reptiles. This reaches its greatest extent in artiodactyls, where the distal surface of the bone has a smooth keel to allow greater freedom of movement of the foot, and thus increase running speed" ; oboInOwl:hasDbXref "BTO:0002354", "EMAPA:19135", "FMA:9708", "GAID:196", "MA:0001351", "MESH:D013628", "NCIT:C52799", "SCTID:182098005", "UMLS:C0039277", "Wikipedia:Talus_bone", "galen:Talus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "astragaloid bone", "astragalus", "astragalus bone", "major ankle bone", "os tarsi tibiale", "os trigonum" ; oboInOwl:id "UBERON:0002395" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "talus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000979 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011679 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0011678 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0012126 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG"^^xsd:anyURI . obo:UBERON_0002396 obo:IAO_0000115 "The triangular flat bone of the nasal septum." ; obo:UBPROP_0000001 "Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO]", "Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO]", "relationship loss: overlaps mesethmoid-vomer joint (TAO:0001680)[TAO]" ; obo:UBPROP_0000003 "In bony fish, the vomers are flattened, paired, bones forming the anterior part of the roof of the mouth, just behind the premaxillary bones. In many species, they have teeth, supplementing those in the jaw proper; in some extinct species the teeth on the vomers were actually larger than the primary set. In amphibians and reptiles, the vomers become narrower, due to the presence of the enlarged choanae (the inner part of the nostrils) on either side, and they may extend further back in the jaw. They are typically small in birds, where they form the upper hind part of the beak, again being located between the choanae. In mammals, the vomers have become narrower still, and are fused into a single, vertically oriented bone. The development of the hard palate beneath the vomer means that the bone is now located in a nasal chamber, separate from the mouth[WP]" ; obo:UBPROP_0000005 "The vomer is paired in some taxa (e.g., Amia) while unpaired in others (e.g., teleosts).[TAO]" ; oboInOwl:hasDbXref "AAO:0000633", "FMA:9710", "MA:0001496", "MESH:D055172", "NCIT:C33888", "SCTID:272678009", "TAO:0000308", "UMLS:C0242403", "Wikipedia:Vomer", "ZFA:0000308" ; oboInOwl:hasExactSynonym "vomer bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prevomer" ; oboInOwl:id "UBERON:0002396" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vomer" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011085 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid124592 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg"^^xsd:anyURI . obo:UBERON_0002397 obo:IAO_0000115 "The bone which normally forms the lateral upper jaw in osteichthyans, including tetrapods." ; obo:UBPROP_0000001 "Dermal bone that forms part of the upper jaw, located antero-ventral to the premaxilla. The maxilla is a paired bone.[TAO]", "Paired, intramembranous bone located on the lateral sides of the skull, posterior to the premaxillae.[AAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps autopalatine-maxillary joint (TAO:0001942)[TAO]", "relationship loss: overlaps premaxillary-maxillary joint (TAO:0002260)[TAO]" ; obo:UBPROP_0000005 "In some teleosts, the maxilla is located postero-ventral to the supramaxilla. Commonly, the articular process of the maxilla articulates with the autopalatine and ethmoidal region antero-medially. The maxilla is usually the largest bone in the upper jaw assemblage.[TAO]" ; obo:UBPROP_0000007 "maxillary" ; oboInOwl:hasBroadSynonym "upper jaw bone" ; oboInOwl:hasDbXref "AAO:0000285", "CALOHA:TS-2217", "EHDAA2:0001068", "EHDAA:8043", "EMAPA:17639", "FMA:9711", "GAID:220", "MA:0001491", "MESH:D008437", "NCIT:C26470", "SCTID:181813003", "TAO:0000270", "UMLS:C0024947", "VHOG:0001021", "VSAO:0000207", "Wikipedia:Maxilla", "ZFA:0000270", "galen:Maxilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillae", "maxillary bone" ; oboInOwl:id "UBERON:0002397" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Fusion of maxilla + premaxilla" ; rdfs:label "maxilla" ; rdfs:subClassOf obo:UBERON_0002514, obo:UBERON_0008193, obo:UBERON_0008907, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_7500102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002244 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001708 ], _:genid124606, _:genid124608, _:genid124610, _:genid124613 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png"^^xsd:anyURI . obo:UBERON_0002398 obo:IAO_0000115 "Distal segment of the fore limb, including carpal region, metacarpal region and digits." ; obo:IAO_0000232 "like all limb segments, this class encompasses both the unformed hand region of the embryo to the fully formed structure complete with skeleton" ; obo:UBPROP_0000007 "manual" ; oboInOwl:hasDbXref "AAO:0010803", "BTO:0004668", "CALOHA:TS-2213", "EHDAA2:0000728", "EMAPA:17428", "FMA:9712", "GAID:56", "MA:0000037", "MESH:D006225", "NCIT:C32712", "NLXANAT:20090603", "SCTID:302539009", "UMLS:C0018563", "VHOG:0000344", "Wikipedia:Manus_(anatomy)", "galen:Hand" ; oboInOwl:hasExactSynonym "forelimb autopod", "forelimb autopodium", "hand", "hand region", "terminal segment of free upper limb" ; oboInOwl:hasNarrowSynonym "fore foot", "fore paw", "fore-paw", "forefeet", "forefoot", "forefoot of quadruped", "forepaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002398" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "manus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006875 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001442 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002470 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/LeftHand0.jpg"^^xsd:anyURI . obo:UBERON_0002400 obo:IAO_0000115 "The outer serous membrane of the pulmonary pleural." ; oboInOwl:hasDbXref "EMAPA:16776", "FMA:9733", "MA:0002488", "NCIT:C33273", "SCTID:361998003", "UMLS:C0225777", "VHOG:0001495", "Wikipedia:Parietal_pleura" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pleura parietalis" ; oboInOwl:id "UBERON:0002400" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax" ; rdfs:label "parietal pleura" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003727 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000977 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0002401 obo:IAO_0000115 "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." ; obo:UBPROP_0000001 "Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]." ; obo:UBPROP_0000012 "FMA treats this as part of the lungs" ; oboInOwl:hasDbXref "EHDAA2:0002205", "EMAPA:16777", "FMA:9734", "MA:0002489", "NCIT:C33881", "SCTID:361997008", "UMLS:C0225776", "VHOG:0001496" ; oboInOwl:hasExactSynonym "pleura pulmonalis", "pleura visceralis", "pleura visceralis (pulmonalis)", "pulmonary visceral pleura" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lung mesothelium", "lung pleura", "pulmonary pleura" ; oboInOwl:id "UBERON:0002401" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "visceral pleura" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0008946 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000977 ], _:genid124661 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000977 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0002402 obo:IAO_0000115 "The fluid-filled cavity that lies between the visceral and parietal pleurae." ; obo:UBPROP_0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" ; obo:UBPROP_0000009 "The contraction of the diaphragm creates a negative pressure within the pleural cavity which forces the lungs to expand resulting in passive exhalation and active inhalation. This breathing process can be made forceful through the contraction of the external intercostal muscles which forces the rib cage to expand and add to the negative pressure in the pleural cavity causing the lungs to fill with air. The fluid in the cavity provides lubrication and cushioning" ; obo:UBPROP_0000012 "the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86" ; oboInOwl:hasDbXref "BTO:0004422", "EHDAA2:0001475", "EMAPA:16773", "EMAPA:16774", "FMA:9740", "GAID:95", "MA:0000055", "MESH:D035422", "NCIT:C12840", "SCTID:361999006", "UMLS:C0178802", "VHOG:0000581", "Wikipedia:Pleural_cavity" ; oboInOwl:hasExactSynonym "cavitas pleuralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitum pleuralae", "cavitum pleurale" ; oboInOwl:id "UBERON:0002402" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "pleural cavity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002400 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002401 ], _:genid124677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0009778 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png"^^xsd:anyURI . obo:UBERON_0002405 obo:IAO_0000115 "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." ; obo:UBPROP_0000003 "The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011003", "BILA:0000104", "BTO:0005810", "FMA:9825", "GAID:328", "MA:0002711", "MESH:D007107", "NCIT:C12735", "SCTID:362590003", "TAO:0001159", "UMLS:C0020962", "VHOG:0001247", "Wikipedia:Immune_system", "XAO:0003152", "ZFA:0001159" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002405" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "immune system" ; rdfs:subClassOf obo:UBERON_0015203, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002376 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0000468 ] ; owl:disjointWith obo:UBERON_0002416, obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002406 obo:IAO_0000115 "A double-walled sac containing the heart and the roots of the great vessels." ; oboInOwl:hasDbXref "FMA:9868", "RETIRED_EHDAA2:0001443", "SCTID:361326002", "TAO:0000054" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pericardium" ; oboInOwl:id "UBERON:0002406" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pericardial sac" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002407 ], _:genid124702 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005906 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001074 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002357 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png"^^xsd:anyURI . obo:UBERON_0002407 obo:IAO_0000115 "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." ; obo:UBPROP_0000001 "Peritoneum that surrounds the heart.[AAO]" ; obo:UBPROP_0000007 "pericardial" ; obo:UBPROP_0000012 "In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity", "this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO)", "we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium" ; oboInOwl:hasDbXref "AAO:0010817", "BSA:0000090", "BTO:0000717", "CALOHA:TS-0761", "EFO:0000820", "EHDAA:5376", "EMAPA:16133", "EV:0100023", "FMA:9869", "GAID:569", "MA:0000099", "MAT:0000454", "MESH:D010496", "NCIT:C13005", "RETIRED_EHDAA2:0001443", "SCTID:181295003", "TAO:0000054", "UMLS:C0031050", "VHOG:0001280", "Wikipedia:Pericardium", "XAO:0004182", "ZFA:0000054", "galen:Pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002407" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pericardium" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002359 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002406 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0002349 ], _:genid124705 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png"^^xsd:anyURI . obo:UBERON_0002408 obo:IAO_0000115 "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." ; oboInOwl:hasDbXref "EHDAA:3422", "EHDAA:5378", "EMAPA:19031", "FMA:9870", "MA:0000483", "NCIT:C94500", "SCTID:243956000", "UMLS:C0225969", "VHOG:0000537", "Wikipedia:Parietal_pericardium" ; oboInOwl:hasExactSynonym "lamina parietalis (pericardii serosum)", "lamina parietalis pericardii", "parietal layer of serous pericardium", "parietal pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pericardial sac" ; oboInOwl:id "UBERON:0002408" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "parietal serous pericardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022351 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002357 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png"^^xsd:anyURI . obo:UBERON_0002409 obo:IAO_0000115 "Transudate contained in the pericardial cavity.[FMA]." ; oboInOwl:hasDbXref "BTO:0001016", "FMA:9887", "MA:0002530", "MESH:D000069236", "Wikipedia:Pericardial_fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002409" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "pericardial fluid" ; rdfs:subClassOf obo:UBERON_0007794, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001074 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002425 ] ) ] . obo:UBERON_0002410 obo:IAO_0000115 "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." ; obo:UBPROP_0000001 "Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]", "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" ; obo:UBPROP_0000003 "From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]" ; obo:UBPROP_0000012 "FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib" ; oboInOwl:hasDbXref "AAO:0000033", "BIRNLEX:1123", "BTO:0002507", "CALOHA:TS-2001", "EHDA:10095", "EHDAA2:0000158", "EHDAA:3767", "EMAPA:16984", "FMA:65553", "GAID:706", "MA:0000219", "MESH:D001341", "NCIT:C12673", "SCTID:362481007", "TAO:0001574", "UMLS:C0004388", "UMLS:C1305381", "VHOG:0000396", "Wikipedia:Autonomic_nervous_system", "ZFA:0001574", "neuronames:2054" ; oboInOwl:hasExactSynonym "autonomic division of peripheral nervous system", "autonomic part of peripheral nervous system", "divisio autonomica systematis nervosi peripherici", "pars autonomica systematis nervosi peripherici", "peripheral autonomic nervous system", "visceral nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ANS", "divisio autonomica systematis nervosi peripherici" ; oboInOwl:id "UBERON:0002410" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "autonomic nervous system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001016 ], _:genid124733 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png"^^xsd:anyURI . obo:UBERON_0002411 obo:IAO_0000115 "The small, erectile body located at the anterior end of the vulva." ; obo:UBPROP_0000007 "clitoral" ; oboInOwl:hasDbXref "BTO:0002020", "EHDAA2:0000255", "EHDAA:9360", "EMAPA:30819", "FMA:9909", "GAID:385", "MA:0000382", "MESH:D002987", "NCIT:C12308", "SCTID:181442003", "UMLS:C0008984", "VHOG:0000700", "Wikipedia:Clitoris", "galen:Clitoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002411" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "clitoris" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005056 ], _:genid124751, _:genid124753 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Clitoris_anatomy_labeled-en.svg"^^xsd:anyURI . obo:UBERON_0002412 obo:IAO_0000115 "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." ; obo:IAO_0000116 "Consider changing name to make distinction from inferred superclass 'vertebral element' clear", "we follow FMA in making this an irregular bone - however vertebra have 'epiphyses' which are currently classified as belonging to long bones" ; obo:RO_0002161 obo:NCBITaxon_7901 ; obo:UBPROP_0000001 "Endochondral bone that forms around the notochord and is part of the vertebral column.[TAO]", "Main component of the vertebral column. It consists of two essential parts, a dorsal neural arch and a ventral centrum.[AAO]" ; oboInOwl:hasDbXref "AAO:0000691", "CALOHA:TS-2352", "EFO:0001371", "EMAPA:32740", "FMA:9914", "MA:0000309", "NCIT:C12933", "SCTID:181817002", "TAO:0001189", "UMLS:C0549207", "Wikipedia:Vertebra", "XAO:0004019", "ZFA:0001189", "galen:Vertebra" ; oboInOwl:hasExactSynonym "vertebra bone", "vertebrae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002412" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vertebra" ; rdfs:subClassOf obo:UBERON_0008001, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0002413 obo:IAO_0000115 "A vertebra that is located in the cervical region of the vertebral column." ; obo:UBPROP_0000008 "In some species, some parts of the skull may be composed of vertebra-like elements, e.g. the occipital bone in humans is composed of four vertebra-like segments. In many vertebrate species, cervical vertebrae are variable in number; however, almost all mammals have seven (including those with very short necks relative to body size, such as elephants or whales, and those with very long necks, such as giraffes). The few exceptions include the manatee and the sloths, of which the two-toed sloth has six cervical vertebrae and the three-toed sloth has up to nine cervical vertebrae. In many species, though not in mammals, the cervical vertebrae bear ribs. In many other groups, such as lizards and saurischian dinosaurs, the cervical ribs are large; in birds they are small and completely fused to the vertebrae. The transverse processes of mammals are homologous to the cervical ribs of other amniotes. Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, cervical vertebrae are the smallest of the true vertebrae, and can be readily distinguished from those of the thoracic or lumbar regions by the presence of a foramen (hole) in each transverse process, through which passes the vertebral artery." ; oboInOwl:hasDbXref "EMAPA:17674", "FMA:9915", "GAID:235", "MA:0000311", "MESH:D002574", "NCIT:C12693", "SCTID:181820005", "Wikipedia:Cervical_vertebrae", "XAO:0003076", "galen:CervicalVertebra" ; oboInOwl:hasExactSynonym "cervical vertebrae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vertebrae cervicales" ; oboInOwl:id "UBERON:0002413" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cervical vertebra" ; rdfs:subClassOf obo:UBERON_0004451, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015007 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg"^^xsd:anyURI . obo:UBERON_0002414 obo:IAO_0000115 "Large vertebra of the movable part of the vertebral column, characterized by the absence of the foramen transversarium within the transverse process, and by the absence of facets on the sides of the body." ; obo:UBPROP_0000008 "Whereas all rats had six lumbar vertebrae, variable patterns in mice included mostly five vertebrae in DBA/2J, mostly six vertebrae in C57BL/6J, and a mix in B6129PF2/J" ; oboInOwl:hasDbXref "CALOHA:TS-2364", "EMAPA:18007", "FMA:9921", "GAID:240", "MA:0000312", "MESH:D008159", "NCIT:C12744", "SCTID:181822002", "UMLS:C0024091", "Wikipedia:Lumbar_vertebrae", "galen:LumbarVertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002414" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lumbar vertebra" ; rdfs:subClassOf _:genid123863 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015009 _:genid123861 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c8/Gray93.png"^^xsd:anyURI . obo:UBERON_0002415 obo:IAO_0000115 "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." ; obo:IAO_0000116 "Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin" ; oboInOwl:hasDbXref "AEO:0000109", "BILA:0000117", "BTO:0001348", "EFO:0000963", "EHDAA:9198", "GAID:1245", "MAT:0000094", "MESH:D013623", "MIAA:0000094", "WBbt:0005741", "Wikipedia:Tail" ; oboInOwl:hasExactSynonym "caudal subdivision" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002415" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tail" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000154 ] . obo:UBERON_0002416 obo:IAO_0000115 "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." ; obo:UBPROP_0000003 "(...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0007029" ; oboInOwl:hasDbXref "AEO:0000154", "BILA:0000118", "CALOHA:TS-1299", "CARO:0002001", "EFO:0000807", "EHDAA2:0000836", "EHDAA2_RETIRED:0003154", "EHDAA:6520", "EMAPA:17524", "EV:0100151", "FBbt:00004969", "FMA:72979", "HAO:0000421", "MA:0000014", "MAT:0000033", "MESH:D034582", "MIAA:0000033", "NCIT:C12907", "SCTID:361692004", "TADS:0000108", "UMLS:C0037267", "VHOG:0000403", "Wikipedia:Integumentary_system", "XAO:0000176", "galen:Surface" ; oboInOwl:hasExactSynonym "integumentary system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body surface", "dermal system", "external covering of organism", "integumentum commune", "organism surface", "surface" ; oboInOwl:id "UBERON:0002416" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:pheno_slim ; a owl:Class ; rdfs:label "integumental system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007376 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0013514 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0002423, obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002417 obo:IAO_0000115 "The abdominal segment of the torso." ; oboInOwl:hasDbXref "EMAPA:35104", "FMA:259211", "MA:0000021", "SCTID:362875007", "Wikipedia:Lumbar" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdomen/pelvis/perineum", "lower body", "lower trunk", "lumbar region" ; oboInOwl:id "UBERON:0002417" ; a owl:Class ; rdfs:label "abdominal segment of trunk" ; rdfs:subClassOf obo:UBERON_0009569, obo:UBERON_0011676 . obo:UBERON_0002418 obo:IAO_0000115 "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." ; obo:UBPROP_0000001 "A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]", "Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]", "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]" ; obo:UBPROP_0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" ; obo:UBPROP_0000003 "Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0000060", "AEO:0000087", "BTO:0000206", "EFO:0000949", "EHDAA2:0003087", "EMAPA:32730", "EV:0100141", "FMA:37377", "GAID:99", "MA:0000104", "MAT:0000189", "MESH:D002356", "MIAA:0000189", "NCIT:C12373", "NCIT:C32268", "SCTID:309312004", "TAO:0001501", "UMLS:C0007301", "VHOG:0001207", "VSAO:0000040", "Wikipedia:Cartilage", "XAO:0000170", "ZFA:0005622", "galen:Cartilage" ; oboInOwl:hasExactSynonym "cartilage tissue", "cartilaginous tissue", "chondrogenic tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilage", "cartilages", "portion of cartilage tissue" ; oboInOwl:id "UBERON:0002418" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Previous: \"A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten].\" See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]" ; rdfs:label "cartilage tissue" ; rdfs:subClassOf obo:UBERON_0004755, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002204 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_18085 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000138 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001434 ] ; owl:disjointWith obo:UBERON_0002481 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg"^^xsd:anyURI . obo:UBERON_0002419 obo:IAO_0000115 "A gland that is part of a skin of body [Automatically generated definition]." ; obo:IAO_0000116 "check FMA, use plural for now as general class not there" ; oboInOwl:hasDbXref "EMAPA:35774", "FMA:71878", "MA:0000146", "SCTID:110485007" ; oboInOwl:hasExactSynonym "glandulae cutis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of skin glands", "skin glands", "skin glands set" ; oboInOwl:id "UBERON:0002419" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "skin gland" ; rdfs:subClassOf obo:UBERON_0006003 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] . obo:UBERON_0002420 obo:IAO_0000115 "An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]." ; obo:IAO_0000116 "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the set of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." ; oboInOwl:hasDbXref "BTO:0000235", "CALOHA:TS-1149", "DHBA:10332", "EFO:0000904", "FMA:62514", "SCTID:244434001" ; oboInOwl:hasExactSynonym "basal ganglion of telencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal ganglia", "basal nucleus", "nuclei basales" ; oboInOwl:id "UBERON:0002420" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "basal ganglion" ; rdfs:subClassOf obo:UBERON_0007245, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010011 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Basal_Ganglia_and_Related_Structures.svg"^^xsd:anyURI . obo:UBERON_0002421 obo:IAO_0000115 "Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment]." ; obo:IAO_0000232 "The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum" ; obo:RO_0002171 obo:UBERON_0002264 ; obo:UBPROP_0000012 "BTO:0000601 is placed here since it includes the DG. GO also includes dentate gyrus development as part of hippocampus development, so we assume when GO says 'hippocampus' it means 'hippocampal formation'. In ABA HPF = (.. subiculum) + HIP, HIP = DG + AH." ; oboInOwl:hasDbXref "BAMS:HPF", "BAMS:Hi", "BAMS:HiF", "BIRNLEX:715", "BM:Tel-HF", "BTO:0000601", "DHBA:10294", "EMAPA:35405", "FMA:74038", "HBA:4249", "MA:0000189", "MBA:1089", "PBA:4003", "SCTID:422867004", "UMLS:C0175202", "Wikipedia:Hippocampal_formation", "neuronames:177" ; oboInOwl:hasExactSynonym "hippocampus (Crosby)" ; oboInOwl:hasNarrowSynonym "hippocampus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "archipallium", "formatio hippocampi", "major hippocampus", "primal cortex", "seahorse" ; oboInOwl:id "UBERON:0002421" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hippocampal formation" ; rdfs:subClassOf obo:UBERON_0002616, _:genid124841, _:genid124843 . obo:UBERON_0002422 obo:IAO_0000115 "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." ; obo:UBPROP_0000001 "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]", "Irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.[AAO]", "The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space[GO][GO:0021592]." ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011043", "BAMS:4V", "BAMS:V4", "BIRNLEX:1256", "BM:Pons-4V", "BTO:0003426", "CALOHA:TS-2015", "DHBA:10669", "DHBA:12805", "DMBA:126651782", "EHDAA2:0000100", "EHDAA:896", "EMAPA:16917", "EV:0100310", "FMA:78469", "GAID:610", "HBA:9421", "MA:0000196", "MBA:145", "MESH:D020546", "NCIT:C12828", "SCTID:180932000", "TAO:0000110", "UMLS:C0149556", "VHOG:0000006", "Wikipedia:Fourth_ventricle", "XAO:0003099", "ZFA:0000110", "neuronames:621" ; oboInOwl:hasExactSynonym "ventricle IV" ; oboInOwl:hasNarrowSynonym "rhombencephalic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "4th ventricle", "IVth ventricle", "fourth ventricle proper", "hindbrain ventricle", "rhombencephalic ventricle", "ventricle of hindbrain", "ventricle of rhombencephalon", "ventriculus quartus" ; oboInOwl:id "UBERON:0002422" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "fourth ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002028 ], _:genid124861 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004086 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png"^^xsd:anyURI . obo:UBERON_0002423 obo:IAO_0000115 "The part of the digestive system that contains the liver and the biliary system." ; obo:UBPROP_0000001 "System responsible for the production and movement of bile[ZFIN:curator]." ; obo:UBPROP_0000009 "The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. The parts are: liver, bile duct, gall bladder and hepatic duct [GO:0061008]" ; oboInOwl:hasDbXref "AAO:0011056", "CALOHA:TS-1308", "EFO:0000800", "EHDAA2:0000998", "EHDAA:2189", "EMAPA:16840", "EV:0100088", "MA:0000324", "MAT:0000024", "MIAA:0000024", "NCIT:C43612", "TAO:0000036", "UMLS:C1711359", "VHOG:0000294", "Wikipedia:Hepatobiliary_system", "XAO:0000132", "ZFA:0000036" ; oboInOwl:hasExactSynonym "hepaticobiliary system", "liver and biliary system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "liver/biliary system" ; oboInOwl:id "UBERON:0002423" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatobiliary system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002294 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061007 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0004456, obo:UBERON_8450002 . obo:UBERON_0002424 obo:IAO_0000115 "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." ; obo:IAO_0000116 "consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar)" ; obo:UBPROP_0000001 "The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]." ; obo:UBPROP_0000011 "the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme" ; oboInOwl:hasDbXref "AAO:0010357", "BTO:0001775", "CALOHA:TS-0715", "EHDAA2:0001325", "EHDAA:2187", "EMAPA:16839", "EMAPA:26942", "FMA:265152", "MA:0000344", "NCIT:C49595", "TAO:0000816", "UMLS:C1709332", "VHOG:0000187", "XAO:0003201", "ZFA:0000816" ; oboInOwl:hasExactSynonym "epithelium of mucosa of mouth", "epithelium of oral mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002424" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "oral epithelium" ; rdfs:subClassOf _:genid124893 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] ) ] . obo:UBERON_0002425 obo:IAO_0000115 "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." ; oboInOwl:hasDbXref "EMAPA:16589", "EMAPA:19032", "FMA:84882", "MA:0000484", "SCTID:243955001", "VHOG:0000538", "Wikipedia:Visceral_pericardium" ; oboInOwl:hasExactSynonym "lamina visceralis pericardii serosi", "serous visceral pericardium", "visceral lamina of serous pericardium", "visceral layer of serous pericardium", "visceral pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epicardium", "pericardium visceral mesothelium" ; oboInOwl:id "UBERON:0002425" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "visceral serous pericardium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002407 ], _:genid124905, _:genid124907 ; owl:equivalentClass _:genid123975 . obo:UBERON_0002426 obo:IAO_0000115 "Any muscle organ that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0000508", "CALOHA:TS-1037", "EMAPA:17747", "EMAPA:17748", "FMA:9619", "MA:0000548" ; oboInOwl:hasExactSynonym "anterior thoracic region muscle organ", "anterolateral part of thorax muscle organ", "chest muscle organ", "front of thorax muscle organ", "muscle of thorax", "muscle organ of anterior thoracic region", "muscle organ of anterolateral part of thorax", "muscle organ of chest", "muscle organ of front of thorax", "musculus thoracicus", "thoracic muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002426" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "chest muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0002427 obo:IAO_0000115 "A zone of skin that is part of an arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37350", "MA:0000596", "NCIT:C52754", "UMLS:C0222204" ; oboInOwl:hasExactSynonym "skin of arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brachial region skin" ; oboInOwl:id "UBERON:0002427" ; a owl:Class ; rdfs:label "arm skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0002428 obo:IAO_0000115 "A bone that is part of a limb [Automatically generated definition]." ; obo:IAO_0000232 "the formal definition is very inclusive, and includes sesamoids" ; obo:UBPROP_0000012 "NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle" ; oboInOwl:hasDbXref "EFO:0000945", "MAT:0000151", "MIAA:0000151", "NCIT:C32223", "SCTID:304149004", "UMLS:C0582791" ; oboInOwl:hasExactSynonym "bone of extremity", "bone of limb", "free limb bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002428" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "limb bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004381 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010881 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0002429 obo:IAO_0000115 "Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted]." ; oboInOwl:hasDbXref "FMA:61213", "MA:0000736", "NCIT:C32298", "SCTID:181757009", "UMLS:C0588054", "Wikipedia:Cervical_lymph_nodes" ; oboInOwl:hasExactSynonym "lymph node of neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002429" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cervical lymph node" ; owl:equivalentClass _:genid124021 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg"^^xsd:anyURI . obo:UBERON_0002435 obo:IAO_0000115 "A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO]." ; obo:RO_0002171 obo:UBERON_0006514 ; obo:UBPROP_0000007 "striatal" ; obo:UBPROP_0000012 "FMA divides 'striatum of neuraxis' into 4, neostriatum is seperate class. In NIF these are synonyms. TODO - check striatum vs corpus striatum see Wikipedia:Striatum#History. Check caudoputamen" ; oboInOwl:hasDbXref "BAMS:STR", "BAMS:Str", "BAMS:Striatum", "BIRNLEX:1672", "BM:N", "BTO:0000418", "DHBA:10333", "DMBA:15851", "EFO:0000109", "EMAPA:17549", "FMA:77618", "FMA:83683", "HBA:4277", "MA:0000891", "MBA:477", "MESH:D017072", "NCIT:C111122", "PBA:10080", "UMLS:C0162512", "Wikipedia:Striatum", "ncithesaurus:Striatum", "neuronames:225" ; oboInOwl:hasExactSynonym "neostriatum", "neuraxis striatum", "striate nucleus", "striatum", "striatum of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudate putamen", "corpus striatum", "corpus striatum (Zilles)", "dorsal striatum", "striated nucleus" ; oboInOwl:id "UBERON:0002435" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "striatum" ; rdfs:subClassOf obo:UBERON_0002020, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0010011 ], _:genid124955, _:genid124957, _:genid124959, _:genid124961 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg"^^xsd:anyURI . obo:UBERON_0002437 obo:IAO_0000115 "White matter that is part of a cerebral hemisphere." ; obo:IAO_0000232 "sometimes the term 'cerebral white matter' may be used generically but here is refers specifically to the white matter in a hemisphere" ; obo:UBPROP_0000012 "The BTO class is inconsistent as it is part of the brain and spinal cord." ; oboInOwl:hasDbXref "BAMS:cw", "BIRNLEX:711", "BTO:0000236", "CALOHA:TS-2362", "EMAPA:35237", "FMA:241998", "FMA:256174", "FMA:61822", "MA:0000945", "NCIT:C49347", "SCTID:361691006", "UMLS:C0152295", "UMLS:C1284115", "neuronames:189" ; oboInOwl:hasExactSynonym "cerebral hemisphere white matter", "cerebral white matter", "white matter structure of cerebral hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hemisphere white matter", "region of cerebral white matter", "substantia medullaris cerebri" ; oboInOwl:id "UBERON:0002437" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebral hemisphere white matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] ) ] . obo:UBERON_0002442 oboInOwl:hasDbXref "EMAPA:37719", "FMA:65265", "MA:0001175" ; oboInOwl:hasExactSynonym "right axillary neural trunk", "trunk of right axillary nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "circumflex nerve trunk" ; oboInOwl:id "UBERON:0002442" ; a owl:Class ; rdfs:label "axillary nerve trunk" ; owl:equivalentClass _:genid124060 . obo:UBERON_0002443 obo:IAO_0000115 "A blood vessel that is part of a choroid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17828", "FMA:76550", "MA:0001237" ; oboInOwl:hasExactSynonym "blood vessel of choroid", "blood vessel of choroid coat", "blood vessel of choroidea", "blood vessel of posterior uvea", "choroid blood vessel", "choroid blood vessels", "choroid blood vessels set", "choroid coat blood vessel", "choroidea blood vessel", "posterior uvea blood vessel", "vasa sanguinea choroideae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of choroid blood vessels" ; oboInOwl:id "UBERON:0002443" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "cannot find singular in FMA, using Set class" ; rdfs:label "choroidal blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001776 ] ) ] . obo:UBERON_0002445 obo:IAO_0000115 "The postaxial bone of the proximal carpal region. Found in close approximation to the ulna, often in articulation[PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "One of two element that constitute the basal row of carpals. It articulates with the ulna, radius, radiale, centrale (element Y), and carpal 5(4). This element originates from one condensation center or the fusion of two elements (ulnare and intermedium). Occasionally it may fuse to carpal 5(4), the radiale, or other elements.[AAO]" ; obo:UBPROP_0000013 "this bone is termed the triquetral bone in some mammalian taxa, notably humans" ; oboInOwl:hasDbXref "AAO:0000845", "EMAPA:36167", "FMA:23715", "MA:0001347", "NCIT:C12858", "SCTID:181965000", "UMLS:C0223739", "Wikipedia:Triquetral", "galen:Triquetral" ; oboInOwl:hasExactSynonym "cuneiform bone of hand", "cuneiform bone of manus", "os triquetrum", "os ulnare", "triangular bone", "triquetral", "triquetral bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cuneiform of hand", "triangular", "triquetrum", "ulnar carpal bone" ; oboInOwl:id "UBERON:0002445" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "ulnare" ; rdfs:subClassOf obo:UBERON_0001480, [ a owl:Restriction ; owl:onProperty obo:BSPO_0001115 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001480 [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Carpus.png"^^xsd:anyURI . obo:UBERON_0002446 obo:IAO_0000115 "A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad]." ; obo:UBPROP_0000007 "patellar" ; oboInOwl:hasDbXref "EMAPA:35668", "FMA:24485", "GAID:203", "MA:0001374", "MESH:D010329", "NCIT:C33282", "SCTID:182083008", "UMLS:C0030647", "Wikipedia:Patella", "galen:Patella" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "knee bone", "knee cap", "patella" ; oboInOwl:id "UBERON:0002446" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella." ; rdfs:label "patella" ; rdfs:subClassOf obo:UBERON_0001479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg"^^xsd:anyURI . obo:UBERON_0002450 obo:IAO_0000115 "The maternal uterine-derived portion of the placenta." ; obo:IAO_0000116 "TODO - check mp syn" ; obo:UBPROP_0000011 "formed under the influence of progesterone and forms highly-characteristic cells. [Wikipedia:Decidua]" ; oboInOwl:hasDbXref "BTO:0001360", "CALOHA:TS-0193", "EMAPA:35269", "FMA:85538", "GAID:378", "MA:0001722", "MAT:0000290", "MESH:D003656", "MIAA:0000290", "NCIT:C32425", "SCTID:362842004", "UMLS:C0011106", "Wikipedia:Decidua" ; oboInOwl:hasExactSynonym "decidous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "decidua basalis", "endometrium", "extraembryonic part of placenta", "extraembryonic placenta", "maternal decidual layer", "maternal part of placenta", "maternal placenta", "placenta maternal decidual layer", "uterine decidua" ; oboInOwl:id "UBERON:0002450" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "decidua" ; rdfs:subClassOf obo:UBERON_0000478, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000459 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001987 ], _:genid125045 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray33.png"^^xsd:anyURI . obo:UBERON_0002451 obo:IAO_0000115 "The mucous secreting gland associated with the mucuous membrane lining the uterus." ; obo:UBPROP_0000010 "simple or branched tubular" ; obo:UBPROP_0000202 obo:FMA_71647 ; oboInOwl:hasDbXref "BTO:0003433", "BTO:0004518", "EMAPA:29919", "MA:0001726", "NCIT:C33842", "SCTID:361377009", "UMLS:C1183035", "Wikipedia:Uterine_glands" ; oboInOwl:hasExactSynonym "endometrial gland", "endometrial mucuous gland", "endometrium gland", "glandulae uterinae", "uterine gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandulae uterinae" ; oboInOwl:id "UBERON:0002451" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "endometrial gland" ; rdfs:subClassOf obo:UBERON_0000414, _:genid124129, _:genid125064 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray1169.png"^^xsd:anyURI . obo:UBERON_0002453 obo:IAO_0000115 "The evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses." ; oboInOwl:hasDbXref "FMA:84115", "GAID:356", "MA:0001792", "MESH:D005005", "NCIT:C12276", "SCTID:181206009", "UMLS:C0015028", "Wikipedia:Ethmoid_bone_sinus" ; oboInOwl:hasExactSynonym "ethmoidal bone sinus", "ethmoidal sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cellulae ethmoidales", "ethmoidal air cell" ; oboInOwl:id "UBERON:0002453" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "ethmoid sinus" ; rdfs:subClassOf obo:UBERON_0001825 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg"^^xsd:anyURI . obo:UBERON_0002456 obo:IAO_0000115 "An artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted]." ; obo:UBPROP_0000012 "MA has both mammary and thoracic" ; oboInOwl:hasDbXref "EHDAA2:0000880", "EHDAA:8585", "EMAPA:18617", "FMA:3960", "MA:0001982", "MA:0001984", "NCIT:C52941", "SCTID:244239009", "UMLS:C0226276", "Wikipedia:Internal_thoracic_artery" ; oboInOwl:hasExactSynonym "internal mammary artery", "internal thoracic mammary artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria mammaria interna", "arteria thoracica interna", "mammary artery" ; oboInOwl:id "UBERON:0002456" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "internal thoracic artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000310 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001533 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray522.png"^^xsd:anyURI . obo:UBERON_0002457 obo:IAO_0000115 "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." ; obo:UBPROP_0000001 "Arteries that connect the dorsal aorta and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these vessels don't have venous or arteriproperty_value external_definitionmarkers. They form from the primary sprouts from the dorsal aorta[ZFA:0001061]." ; obo:UBPROP_0000003 "Few changes of evolutionary significance occur in the branching pattern of the dorsal aorta. All vertebrates have (...) paired intersegmental arteries to the trunk, tail, and paired appendages.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0006001" ; oboInOwl:hasDbXref "EHDAA2:0000882", "EHDAA:4340", "EMAPA:17616", "MA:0001985", "SCTID:360401001", "TAO:0001061", "VHOG:0000225", "XAO:0004165", "ZFA:0001061" ; oboInOwl:hasExactSynonym "intersegmental artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intersegmental arteries" ; oboInOwl:id "UBERON:0002457" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intersomitic artery" ; rdfs:subClassOf obo:UBERON_0001637, obo:UBERON_0014907 . obo:UBERON_0002458 obo:IAO_0000115 "Arteries that supply the spinal cord." ; oboInOwl:hasDbXref "EHDAA2:0001890", "EHDAA:4355", "EMAPA:18241", "MA:0002043", "NCIT:C33587", "SCTID:244228006", "TAO:0000682", "UMLS:C0447043", "Wikipedia:Spinal_artery", "ZFA:0000682" ; oboInOwl:hasExactSynonym "spinal arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002458" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "spinal artery" ; rdfs:subClassOf obo:UBERON_0004573 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0002459 obo:IAO_0000115 "A blood vessel that drains from from an lower eyelid." ; obo:UBPROP_0000202 obo:FMA_70847 ; oboInOwl:hasDbXref "EMAPA:37156", "FMA:50913", "MA:0002147", "NCIT:C53049", "SCTID:422559003", "UMLS:C1760539" ; oboInOwl:hasExactSynonym "inferior palpebral veins", "inferior palpebral veins set", "vein of inferior eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower palpebral vein", "venae palpebrales inferiores" ; oboInOwl:id "UBERON:0002459" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inferior palpebral vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014769 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0002460 obo:IAO_0000115 "A tributary of the iliac vein that drains the urinary bladder." ; obo:UBPROP_0000202 obo:FMA_70911 ; oboInOwl:hasDbXref "EMAPA:37205", "MA:0002263", "SCTID:12683000", "Wikipedia:Vesical_veins" ; oboInOwl:hasExactSynonym "venae vesicales", "vesical veins", "vesical veins set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002460" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "vesical vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png"^^xsd:anyURI . obo:UBERON_0002461 obo:IAO_0000115 "Any skeletal muscle organ that is part of a anterior abdominal wall. Examples: the obliques, pyramidalis and transversus abdominus." ; oboInOwl:hasDbXref "EHDAA2:0000125", "EMAPA:17744", "EMAPA:17745", "FMA:20278", "MA:0002268", "NCIT:C52890", "UMLS:C1744565" ; oboInOwl:hasExactSynonym "muscle of anterior abdominal wall", "ventral abdominal wall muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002461" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "anterior abdominal wall muscle" ; rdfs:subClassOf obo:UBERON_0002378, _:genid125123 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid124185 ] . obo:UBERON_0002463 obo:IAO_0000115 "Any of the posterior thigh muscles. [WP,modified]." ; obo:IAO_0000116 "check FMA, singular." ; oboInOwl:hasAlternativeId "UBERON:0008538" ; oboInOwl:hasDbXref "BTO:0003179", "EHDAA2:0000727", "EHDAA:8295", "EMAPA:19145", "FMA:22427", "FMA:81022", "MA:0002312", "NCIT:C53042", "UMLS:C0584895", "VHOG:0000844", "Wikipedia:Hamstring", "Wikipedia:Posterior_compartment_of_thigh" ; oboInOwl:hasExactSynonym "hamstring muscle", "muscle of posterior compartment of thigh", "posterior femoral muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hamstring", "muscularis compartimentum femoris posterius", "posterior fascial compartment of thigh", "posterior femoral muscles", "set of hamstring muscles" ; oboInOwl:id "UBERON:0002463" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "muscle of posterior compartment of hindlimb stylopod" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ], _:genid125130, _:genid125132, _:genid125134, _:genid125136 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Biceps_femoris_muscle_long_head.PNG"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray1239.png"^^xsd:anyURI . obo:UBERON_0002464 obo:UBPROP_0000001 "Segment of neural tree organ which consists of nerve fiber bundles aggregated to form a cable-like structure that branches off to different nerves; together with all nerves of the same tree. Example: trunk of cranial nerve, trunk of spinal nerve, trunk of peripheral nerve[FMA:5913]." ; oboInOwl:hasAlternativeId "UBERON:0001147" ; oboInOwl:hasDbXref "BTO:0000927", "EHDAA:4675", "EMAPA:16986", "FMA:14383", "FMA:5913", "MA:0000229", "MA:0002408", "SCTID:281248001" ; oboInOwl:hasExactSynonym "peripheral nerve trunk", "trunk of nerve", "trunk of peripheral nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002464" ; a owl:Class ; rdfs:label "nerve trunk" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001021 ] ; owl:disjointWith obo:UBERON_0003439 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000122 [ a owl:Restriction ; owl:onProperty core:trunk_part_of ; owl:someValuesFrom obo:UBERON_0001021 ] ) ] . obo:UBERON_0002465 obo:IAO_0000115 "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." ; obo:UBPROP_0000001 "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" ; obo:UBPROP_0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" ; obo:UBPROP_0000007 "lymphoid" ; obo:UBPROP_0000008 "The lymphatic system of anuran amphibians is characterized by large lymphatic sacs and two pairs of lymph hearts that return lymph into the venous circulation but no lymph vessels per se [10.1152/japplphysiol.00201.2013]", "The lymphatic systems of reptiles and some birds have lymph hearts, and both groups have extensive lymph vessels, but their functional role in both lymph movement and plasma volume homeostasis is almost completely unknown [10.1152/japplphysiol.00201.2013]" ; obo:UBPROP_0000012 "We follow FMA and MA in distinguishing between lymphatic system and lymphoid system, with lymhoid tissue part of the non-lymphatic component, although these terms are often used interchangeably. We assume the ZFA term lymphatic tissue actually corresponds to the broader class (e.g. ZFA lymph node in the ZFA lymphatic system). See tracker for more comments." ; oboInOwl:hasAlternativeId "UBERON:0002096" ; oboInOwl:hasDbXref "EHDAA2:0001043", "EHDAA:8677", "EMAPA:37664", "FMA:74594", "GAID:931", "MA:0002435", "MAT:0000197", "MIAA:0000197", "NCIT:C12746", "SCTID:362589007", "TAO:0000385", "UMLS:C0024235", "VHOG:0000842", "Wikipedia:Lymphoid_system", "XAO:0003199", "ZFA:0000385" ; oboInOwl:hasNarrowSynonym "lymphatic system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymphatic circulatory system", "lymphatic drainage system", "systema lymphoideum" ; oboInOwl:id "UBERON:0002465" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lymphoid system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ], _:genid125155 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/TE-Lymphatic_system_diagram.svg"^^xsd:anyURI . obo:UBERON_0002466 obo:IAO_0000115 "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." ; oboInOwl:hasDbXref "BTO:0000644", "FMA:62974", "GAID:1162", "MA:0002515", "MESH:D007419", "NCIT:C32875", "UMLS:C0021849", "Wikipedia:Succus_entericus" ; oboInOwl:hasExactSynonym "intestinal secretion", "succus entericus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal juice" ; oboInOwl:id "UBERON:0002466" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "intestine secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0002469 obo:IAO_0000115 "A mucosa that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003345" ; oboInOwl:hasDbXref "BTO:0002859", "EMAPA:26981", "FMA:62996", "MA:0002680", "MESH:D000071041", "NCIT:C32538", "SCTID:362127004", "UMLS:C0227176" ; oboInOwl:hasExactSynonym "esophageal mucosa", "esophageal mucous membrane", "esophagus mucosa", "esophagus mucous membrane", "lamina muscularis mucosae oesophageae", "mucosa of esophagus", "mucosa of oesophagus", "mucous membrane of esophagus", "mucous membrane of oesophagus", "oesophageal mucosa", "oesophagus mucosa", "oesophagus mucous membrane", "tunica mucosa esophagi", "tunica mucosa oesophageae", "tunica mucosa oesophagi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscularis mucosae of oesophagus", "tunica mucosa oesophagi" ; oboInOwl:id "UBERON:0002469" ; a owl:Class ; rdfs:label "esophagus mucosa" ; rdfs:subClassOf _:genid124241 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 _:genid124239 ) ] . obo:UBERON_0002470 obo:IAO_0000115 "Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot." ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group; note that this refers to the limb segment, not just the skeleton." ; oboInOwl:hasBroadSynonym "autopod" ; oboInOwl:hasDbXref "BTO:0004359", "EFO:0000877", "EMAPA:32722", "FMA:83015", "MA:0002714", "MAT:0000091", "MIAA:0000091", "NCIT:C77660", "SCTID:95936004", "UMLS:C0687080" ; oboInOwl:hasExactSynonym "autopodial limb segment", "autopodial segment", "autopodium", "autopodium region", "distal free limb segment", "distal segment of free limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "autopodial element", "distal segment of limb", "manus/pes", "paw", "paw/hand/foot/hoof", "pod" ; oboInOwl:id "UBERON:0002470" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "autopod region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002101 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0002471 ], _:genid125199 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0006717 ] ) ] . obo:UBERON_0002471 obo:IAO_0000115 "The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus)." ; obo:UBPROP_0000007 "zeugopodial" ; oboInOwl:hasBroadSynonym "middle part of limb" ; oboInOwl:hasDbXref "EFO:0000878", "FMA:83016", "MA:0002716", "MAT:0000092", "MIAA:0000092" ; oboInOwl:hasExactSynonym "epipodium", "middle free limb segment", "middle limb segment", "zeugopod limb segment", "zeugopodial limb segment", "zeugopodium", "zygopod", "zygopodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "middle segment of free limb" ; oboInOwl:id "UBERON:0002471" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "There exists some controversy about which podial segments are present in some fishes, e.g. if the autopod is not newly evolved in tetrapods, there is a question as to which segments are actually present in basal vertebrate taxa.[PHENOSCAPE:curators]" ; rdfs:label "zeugopod" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000097 ; owl:someValuesFrom obo:UBERON_0002472 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000100 ; owl:someValuesFrom obo:UBERON_0002470 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011584 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 _:genid124271 ) ] . obo:UBERON_0002472 obo:IAO_0000115 "The proximal free limb segment. Includes as parts the stylopod skeleton." ; obo:RO_0002171 obo:UBERON_0002470, obo:UBERON_0002471 ; obo:UBPROP_0000007 "stylopodial" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group" ; oboInOwl:hasBroadSynonym "proximal part of limb" ; oboInOwl:hasDbXref "EFO:0000879", "FMA:83014", "MA:0002717", "MAT:0000093", "MIAA:0000093" ; oboInOwl:hasExactSynonym "propodium", "proximal free limb segment", "stylopodial limb segment", "stylopodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal segment of free limb" ; oboInOwl:id "UBERON:0002472" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "stylopod" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000100 ; owl:someValuesFrom obo:UBERON_0002471 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011583 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid124283 ] . obo:UBERON_0002473 obo:IAO_0000115 "A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum." ; oboInOwl:hasDbXref "EMAPA:35435", "FMA:67930", "MA:0002721", "SCTID:360567002", "neuronames:1559" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "commissure of cerebrum", "inter-hemispheric commissure", "interhemispheric commissure" ; oboInOwl:id "UBERON:0002473" ; a owl:Class ; rdfs:label "intercerebral commissure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002437 ] ; owl:equivalentClass _:genid124294 . obo:UBERON_0002474 obo:IAO_0000115 "A composite structure of the brain stem, which is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)[NIF, based on NN]." ; obo:IAO_0000116 "TODO - this requires work for making consistent with ABA, which strictly separates cerebellum from brainstem. in MA, cerebellar peduncle is part of both brainstem and cerebellar white matter." ; oboInOwl:hasDbXref "BAMS:cbp", "BIRNLEX:970", "FMA:77791", "MBA:752", "UMLS:C0228514", "Wikipedia:Cerebellar_peduncle", "neuronames:224" ; oboInOwl:hasExactSynonym "cerebellar peduncles", "cerebellar peduncles and decussations", "cerebellar peduncles set", "cerebellum peduncles", "pedunculi cerebellares" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal ganglia (anatomic)", "corpus striatum (Savel'ev)", "ganglia basales", "set of cerebellar peduncles" ; oboInOwl:id "UBERON:0002474" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "cerebellar peduncular complex" ; rdfs:subClassOf obo:UBERON_0002616, _:genid125244, _:genid125246 . obo:UBERON_0002478 obo:IAO_0000115 "The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young." ; obo:UBPROP_0000001 "Endochondral ossification of the lateral sides of the braincase.[AAO]", "Large median unpaired cartilage bone consisting of two diverging plates. Positioned medial to the eye. The orbitosphenoid develops from the Trabeculae communis and forms the anterior and anterolateral boundary of the orbital foramen and constitutes a significant part of the sidewalls and floor of the cranial cavity. Bordered by the lateral ethmoid anteriorly, and the pterosphenoid posteriorly, The orbitosphenoid may extend ventrally to meet the parasphenoid. In the adult, the orbitosphenoid is fused ventrally to the parasphenoid via a thin sheet of bone.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from taenia marginalis anterior (TAO:0001505)[TAO]", "relationship loss: overlaps orbitosphenoid-lateral ethmoid joint (TAO:0001941)[TAO]", "relationship loss: overlaps orbitosphenoid-prootic joint (TAO:0001794)[TAO]", "relationship loss: overlaps pterosphenoid-orbitosphenoid joint (TAO:0001831)[TAO]", "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]", "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: develops_from neurocranium (UBERON:0001703)[TAO]", "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: part_of neurocranium (UBERON:0001703)[TAO]" ; oboInOwl:hasDbXref "AAO:0000345", "EMAPA:18719", "FMA:52869", "MA:0002773", "SCTID:361737003", "TAO:0000253", "VHOG:0001153", "Wikipedia:Lesser_wing_of_sphenoid_bone", "ZFA:0000253" ; oboInOwl:hasExactSynonym "ala minor (os sphenoidale)", "ala minor ossis sphenoidalis", "ingrassia's process", "lesser wing of sphenoid", "lesser wing of sphenoidal bone", "orbitosphenoid bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alae parvae", "lesser wing of sphenoid bone", "orbitosphenoids" ; oboInOwl:id "UBERON:0002478" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "orbitosphenoid" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001677 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005687 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009638 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001677 ], _:genid125262, _:genid125264, _:genid125266 ; owl:equivalentClass _:genid124314 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png"^^xsd:anyURI . obo:UBERON_0002481 obo:IAO_0000115 "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." ; obo:IAO_0000116 "see https://github.com/obophenotype/uberon/issues/27" ; obo:UBPROP_0000001 "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]" ; oboInOwl:hasDbXref "CALOHA:TS-2011", "EMAPA:35179", "FMA:224804", "MA:0002780", "MESH:D001842", "NCIT:C13076", "UMLS:C0391978", "VSAO:0000047", "Wikipedia:Bone_tissue", "XAO:0004040", "ZFA:0005621", "galen:BoneTissue" ; oboInOwl:hasExactSynonym "calcium tissue", "osseous tissue", "osteogenic tissue" ; oboInOwl:hasNarrowSynonym "mineralized bone tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone", "portion of bone tissue" ; oboInOwl:id "UBERON:0002481" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "bone tissue" ; rdfs:subClassOf obo:UBERON_0004755, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ; owl:disjointWith obo:UBERON_0005090 . obo:UBERON_0002482 obo:IAO_0000115 "Bone tissue that has a regular parallel alignment of collagen into sheets (lamellae) and is mechanically strong." ; oboInOwl:hasDbXref "EMAPA:37625", "FMA:224806", "MA:0002781", "Wikipedia:Bone#Woven_or_lamellar", "galen:LamellarBone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002482" ; a owl:Class ; rdfs:comment "histological classification, lamellar vs woven. Note that only FMA has woven" ; rdfs:label "lamellar bone" ; rdfs:subClassOf obo:UBERON_0002481 . obo:UBERON_0002483 obo:IAO_0000115 "Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow." ; oboInOwl:hasDbXref "BTO:0001700", "CALOHA:TS-0110", "EMAPA:35873", "FMA:24019", "MA:0002782", "Wikipedia:Trabecular_bone" ; oboInOwl:hasExactSynonym "cancellous bone", "cancellous bone tissue", "spongy bone", "spongy bone tissue", "substantia spongiosa", "substantia spongiosa ossium", "substantia trabecularis", "trabecular bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cancellated bone", "substantia trabecularis ossium", "trabecular substance" ; oboInOwl:id "UBERON:0002483" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "one of the two types of osseous tissue that form bones. Compared to compact bone, which is the other type of osseous tissue, it has a higher surface area but is less dense, softer, weaker, and less stiff. It typically occurs at the ends of long bones, proximal to joints and within the interior of vertebrae. Cancellous bone is highly vascular and frequently contains red bone marrow where hematopoiesis, which is the production of blood cells, occurs. The primary anatomical and functional unit of cancellous bone is the trabecula." ; rdfs:label "trabecular bone tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002482 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002519 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0008867 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/34/Illu_compact_spongy_bone.jpg"^^xsd:anyURI . obo:UBERON_0002484 obo:IAO_0000115 "The medullary cavities of the bones where bone marrow is stored." ; obo:UBPROP_0000010 "Located in the main shaft (cortical bone) of a long bone (diaphysis) (consisting mostly of compact bone), the medullary cavity has walls composed of spongy bone (cancellous bone) and is lined with a thin, vascular membrane (endosteum)[Wikipedia:Bone_marrow_of_ovaryry_cavity]" ; obo:UBPROP_0000012 "not clear if the FMA intends to have two classes. MP:0000065: 'the medullary cavities of the bones.'. NCITA also has 'medullary bone'" ; oboInOwl:hasDbXref "FMA:75147", "FMA:83698", "MA:0002783", "Wikipedia:Bone_marrow_of_ovaryry_cavity" ; oboInOwl:hasExactSynonym "cavity of cancellous bone", "marrow cavity", "medullary cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002484" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone marrow cavity" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001439 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0002371 ] . obo:UBERON_0002485 obo:IAO_0000115 "The minute canals that pass the prostatic secretions to the urethra." ; oboInOwl:hasDbXref "EMAPA:36568", "FMA:19580", "MA:0002785", "NCIT:C13102", "SCTID:362276000", "UMLS:C0227965", "Wikipedia:Prostatic_ducts" ; oboInOwl:hasExactSynonym "duct of prostate", "duct of prostate gland", "prostate duct", "prostate gland duct", "prostatic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002485" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "prostate duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002367 ], _:genid125325 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0002486 obo:IAO_0000115 "The vocal apparatus of the larynx, which includes the vocal cords and the opening between them." ; obo:UBPROP_0000001 "A small, slit-like aperture lying longitudinally on the floor of the pharynx.[AAO]" ; oboInOwl:hasDbXref "AAO:0010610", "BTO:0001627", "FMA:55414", "GAID:343", "MA:0002788", "MESH:D005931", "NCIT:C12724", "SCTID:264482000", "UMLS:C0017681", "Wikipedia:Glottis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002486" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "glottis" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001737 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Arytenoid_cartilage.png"^^xsd:anyURI . obo:UBERON_0002488 obo:IAO_0000115 "The helix is the prominent rim of the pinna." ; oboInOwl:hasDbXref "FMA:60992", "MA:0002793", "NCIT:C32724", "SCTID:279607004", "UMLS:C0229304", "Wikipedia:Helix_(ear)" ; oboInOwl:hasExactSynonym "helical part of pinna", "helix", "helix (auricula)", "helix of auricle of ear", "helix of ear", "helix of pinna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002488" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "helix of outer ear" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ], _:genid125336 . obo:UBERON_0002489 obo:IAO_0000115 "The dense, fibrous connective tissue joint between the tetrapod parietal bones and the frontal bone." ; oboInOwl:hasDbXref "EMAPA:19225", "FMA:52928", "MA:0002795", "SCTID:244510008", "Wikipedia:Coronal_suture" ; oboInOwl:hasExactSynonym "coronal suture of skull", "fronto-parietal suture", "frontoparietal suture" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sutura coronalis" ; oboInOwl:id "UBERON:0002489" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "coronal suture" ; rdfs:subClassOf obo:UBERON_0003685, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 ] ; owl:equivalentClass _:genid124393 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/ae/Gray188-Coronal_suture.png"^^xsd:anyURI . obo:UBERON_0002490 obo:IAO_0000115 "A suture that connects the two frontal bones of the skull." ; obo:UBPROP_0000008 "in humans, the frontal suture is a dense connective tissue structure that divides the two halves of the frontal bone of the skull in infants and children. It usually disappears by the age of six, with the two halves of the frontal bone being fused together. If it does not disappear it may be called a 'metopic suture' or 'sutura frontalis persistens. ' If the suture is not present at birth (craniosynostosis) it will cause a keel-shaped deformity of the skull called 'trigonocephaly. ' It is present in a fetal skull so that the skull can bend and is very elastic at the time of birth. The baby's head literally bends when coming out of the mother's womb. The space is filled as the child grows older. [WP,unvetted]" ; oboInOwl:hasDbXref "EMAPA:19226", "EMAPA:35358", "FMA:52989", "MA:0002796", "SCTID:136854008", "Wikipedia:Frontal_suture" ; oboInOwl:hasExactSynonym "frontal suture of skull", "median frontal suture", "sutura frontalis", "sutura metopica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metopic suture", "sutura frontalis" ; oboInOwl:id "UBERON:0002490" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "frontal suture" ; rdfs:subClassOf obo:UBERON_0003685, _:genid125356 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 _:genid124406 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png"^^xsd:anyURI . obo:UBERON_0002491 obo:IAO_0000115 "The dense, fibrous connective tissue joint between the parietal bones and the occipital bone." ; oboInOwl:hasDbXref "EMAPA:19227", "FMA:52933", "MA:0002797", "SCTID:361830007", "Wikipedia:Lambdoid_suture" ; oboInOwl:hasExactSynonym "lambdoid suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lambdoidal suture", "sutura lambdoidea" ; oboInOwl:id "UBERON:0002491" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lambdoid suture" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], _:genid125372 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001678 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3d/Gray188-Lambdoid_suture.png"^^xsd:anyURI . obo:UBERON_0002492 obo:IAO_0000115 "The dense, fibrous connective tissue joint between the tetrapod parietal bones." ; oboInOwl:hasDbXref "EMAPA:19224", "FMA:52929", "MA:0002798", "SCTID:244511007", "Wikipedia:Sagittal_suture" ; oboInOwl:hasExactSynonym "sagittal suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sutura sagittalis" ; oboInOwl:id "UBERON:0002492" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "sagittal suture" ; rdfs:subClassOf obo:UBERON_0003685, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 ], _:genid125382 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onClass obo:UBERON_0000210 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/24/Kort-lang-skalle.gif"^^xsd:anyURI . obo:UBERON_0002495 obo:IAO_0000115 "A long bone is a bone that has a shaft and 2 ends and is longer than it is wide. Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow. The ends of a long bone contain spongy bone and an epiphyseal plate or line depending on the stage of development. The epiphyseal plate is a hyaline cartilage, where new bone growth takes place, lengthening the bone prior to adulthood. Bone lengthening ceases when this cartilage is lost, leaving a remnant referred to as an epiphyseal line." ; oboInOwl:hasDbXref "BTO:0004256", "EMAPA:35503", "FMA:7474", "MA:0002802", "NCIT:C33003", "SCTID:332709000", "UMLS:C0222647", "Wikipedia:Long_bone", "galen:LongBone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os longum" ; oboInOwl:id "UBERON:0002495" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "Endochondral_ossification is an essential process during the rudimentary formation of long bones, with the exception of the clavicle[Wikipedia:Endochondral_ossification]. The medial and and lateral ends undergo EO, the mid-portion is formed by a process with features of EO & IO (the process is shared by the mandible)[ISBN:9780397517251]" ; rdfs:label "long bone" ; rdfs:subClassOf obo:UBERON_0001474, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002091 ] . obo:UBERON_0002497 obo:IAO_0000115 "Region of the scapula where the latter meets with the clavicle: attachment point of the clavicle to the scapula in some taxa." ; obo:UBPROP_0000001 "Anterior rounded projection of the pars acromialis of the scapula.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of pars acromialis (AAO:0000752)[AAO]" ; oboInOwl:hasDbXref "AAO:0000826", "EMAPA:25119", "FMA:23260", "GAID:187", "MA:0002805", "MESH:D000174", "NCIT:C32048", "SCTID:181911000", "UMLS:C0001209", "VSAO:0005067", "Wikipedia:Acromion" ; oboInOwl:hasExactSynonym "acromion process", "scapular acromion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acromion of scapula", "acromion of the scapula" ; oboInOwl:id "UBERON:0002497" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "acromion" ; rdfs:subClassOf obo:UBERON_0004530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006849 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/79/Gray206.png"^^xsd:anyURI . obo:UBERON_0002498 obo:IAO_0000115 "A rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches." ; obo:UBPROP_0000008 "In basal Tetrapodomorph lineages often the deltoid process and the pectoral processes are separate and thus should not be made exact synonyms to the deltopectoral crest.[PHENOSCAPE:ad]" ; oboInOwl:hasDbXref "AAO:0000736", "EMAPA:25052", "FMA:23418", "MA:0002808", "Wikipedia:Deltoid_tuberosity" ; oboInOwl:hasExactSynonym "crista ventralis", "deltoid crest", "deltoid eminence", "deltoid impression", "deltoid tuberosity", "deltoid tuberosity of humerus", "tuberositas deltoidea", "tuberositas deltoidea (corpus humeri)", "tuberositas deltoidea humeri" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crista ventralis humeri", "deltoid process", "pectoral process" ; oboInOwl:id "UBERON:0002498" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "deltopectoral crest" ; rdfs:subClassOf obo:UBERON_0005813, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004652 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000976 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/HumerusFront.png"^^xsd:anyURI . obo:UBERON_0002499 obo:IAO_0000115 "The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." ; obo:IAO_0000116 "we follow the FMA in placing this in the membranous labyrinth. Notes: The labyrinth can be divided by layer or by region. Bony vs. membranous / Vestibular vs. cochlear" ; oboInOwl:hasDbXref "BTO:0004686", "EMAPA:36569", "FMA:61259", "MA:0002809", "NCIT:C32336", "UMLS:C0931689", "Wikipedia:Cochlear_labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002499" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cochlear labyrinth" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001844 ], _:genid125413 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png"^^xsd:anyURI . obo:UBERON_0002500 obo:IAO_0000115 "The bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone." ; obo:UBPROP_0000008 "The zygomatic arch is significant in evolutionary biology, as it is part of the structures derived from the ancestral single temporal fenestra of the synapsid ancestor of mammals." ; obo:UBPROP_0000010 "The zygomatic process of the temporal arises by two roots: an anterior, directed inward in front of the mandibular fossa, where it expands to form the articular tubercle. a posterior, which runs backward above the external acoustic meatus and is continuous with the supramastoid crest. The upper border of the arch gives attachment to the temporal fascia; the lower border and medial surface give origin to the Masseter" ; obo:UBPROP_0000013 "The zygomatic arch is occasionally referred to as the zygoma, but this term usually refers to the zygomatic bone or occasionally the zygomatic process." ; oboInOwl:hasDbXref "EMAPA:36570", "FMA:53120", "MA:0002810", "MESH:D015050", "MFMO:0000108", "NCIT:C33897", "SCTID:272682006", "UMLS:C0162485", "Wikipedia:Zygomatic_arch", "galen:Zygoma" ; oboInOwl:hasExactSynonym "zygoma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcus zygomaticus" ; oboInOwl:id "UBERON:0002500" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "zygomatic arch" ; rdfs:subClassOf obo:UBERON_0011164, _:genid125419 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/f4/Gray188-Sphenozygomatic_suture.png"^^xsd:anyURI . obo:UBERON_0002503 obo:IAO_0000115 "The greater trochanter (great trochanter) of the femur is a large, irregular, quadrilateral eminence and a part of the skeletal system. It is directed a little lateralward and backward, and, in the adult, is about 1 cm lower than the head. Because the pelvic outlet in the female is larger than in the male, there is a greater distance between the greater trochanters in the female. It has two surfaces and four borders. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37594", "FMA:32852", "MA:0002822", "NCIT:C32698", "SCTID:182050001", "UMLS:C0223865", "Wikipedia:Greater_trochanter", "galen:GreaterTrochanter" ; oboInOwl:hasExactSynonym "great trochanter", "greater trochanter of femur" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trochanter major" ; oboInOwl:id "UBERON:0002503" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "greater trochanter" ; rdfs:subClassOf obo:UBERON_0000980, _:genid125424 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png"^^xsd:anyURI . obo:UBERON_0002504 obo:IAO_0000115 "The lesser trochanter (small trochanter) of the femur is a conical eminence, which varies in size in different subjects [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37595", "FMA:32853", "MA:0002823", "NCIT:C32982", "SCTID:182051002", "UMLS:C0223866", "Wikipedia:Lesser_trochanter", "galen:LesserTrochanter" ; oboInOwl:hasExactSynonym "lesser trochanter of femur" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trochanter minor" ; oboInOwl:id "UBERON:0002504" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lesser trochanter" ; rdfs:subClassOf obo:UBERON_0000980, _:genid125430 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png"^^xsd:anyURI . obo:UBERON_0002506 obo:IAO_0000115 "An epithelium that is part of a iris [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35447", "FMA:58517", "MA:0002826" ; oboInOwl:hasExactSynonym "epithelial tissue of iris", "epithelium of iris", "epithelium pigmentosum (iris)", "epithelium pigmentosum iridis", "iris epithelial tissue", "iris epithelium", "pigmented epithelium of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "iris pigmented epithelium" ; oboInOwl:id "UBERON:0002506" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "iris epithelium" ; rdfs:subClassOf obo:UBERON_0000488, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001769 ], _:genid125441, _:genid125443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] . obo:UBERON_0002507 obo:IAO_0000115 "A lymph node that is part of an abdomen [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35992", "FMA:12787", "MA:0002827", "SCTID:245342005" ; oboInOwl:hasExactSynonym "abdomen lymph node", "lymph node of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parietal abdominal lymph node" ; oboInOwl:id "UBERON:0002507" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "abdominal lymph node" ; rdfs:subClassOf obo:UBERON_0000029 ; owl:equivalentClass _:genid124498 . obo:UBERON_0002509 obo:IAO_0000115 "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." ; oboInOwl:hasDbXref "BTO:0000767", "EMAPA:35561", "FMA:12795", "MA:0002829", "NCIT:C77641", "UMLS:C0229792", "Wikipedia:Mesenteric_lymph_nodes" ; oboInOwl:hasExactSynonym "mesenteric node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nodi lymphoidei mesenterici" ; oboInOwl:id "UBERON:0002509" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mesenteric lymph node" ; rdfs:subClassOf obo:UBERON_0015860 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002507 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ) ] . obo:UBERON_0002510 obo:IAO_0000115 "In humans, the anterior fontanelle (bregmatic fontanelle, frontal fontanelle) is the largest, and is placed at the junction of the sagittal suture, coronal suture, and frontal suture; it is lozenge-shaped, and measures about 4 cm in its antero-posterior and 2.5 cm in its transverse diameter. The fontanelle allows the skull to deform during birth to ease its passage through the birth canal and for expansion of the brain after birth. While the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior is not completely closed until about the middle of the second year. Full ossification starts in the late twenties and finishes before the age of 50 . [WP,unvetted]." ; obo:UBPROP_0000012 "TAO:0001739 anterior cranial fontanel is 'Fontanel that is located between the contralateral frontals and anterior to the epiphyseal bar'" ; oboInOwl:hasDbXref "EMAPA:19199", "FMA:75439", "MA:0002830", "SCTID:244680006", "Wikipedia:Anterior_fontanelle" ; oboInOwl:hasExactSynonym "anterior fontanelle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bregmatic fontanelle", "fonticulus anterior", "frontal fontanelle" ; oboInOwl:id "UBERON:0002510" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anterior fontanel" ; owl:disjointWith obo:UBERON_0006683 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002221 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002489 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002490 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002492 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png"^^xsd:anyURI . obo:UBERON_0002513 obo:IAO_0000115 "Replacement bone that forms within cartilage." ; obo:IAO_0000116 "placement in this class to be inferred" ; obo:UBPROP_0000001 "Replacement bone that forms within cartilage.[VSAO]" ; obo:UBPROP_0000012 "some structures, e.g. in ZFA are both intramembrane and endochondral" ; oboInOwl:hasDbXref "AAO:0010776", "AEO:0000083", "BTO:0002157", "EHDAA2:0003083", "FMA:24321", "TAO:0001591", "VSAO:0000145", "XAO:0004018", "ZFA:0001591" ; oboInOwl:hasExactSynonym "ossified chondrogenic bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilaginous bone", "endochondral bones" ; oboInOwl:id "UBERON:0002513" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endochondral bone" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0002418 ], _:genid125490 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005863 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg"^^xsd:anyURI . obo:UBERON_0002514 obo:IAO_0000115 "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." ; obo:UBPROP_0000001 "Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO]" ; obo:UBPROP_0000005 "[In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO]" ; oboInOwl:hasDbXref "EMAPA:36615", "TAO:0001644", "Wikipedia:Intramembranous_ossification", "ZFA:0001635" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intramembranous bones", "membrane bone" ; oboInOwl:id "UBERON:0002514" ; a owl:Class ; rdfs:label "intramembranous bone" ; rdfs:subClassOf obo:UBERON_0001474, _:genid124541, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0001957 ] . obo:UBERON_0002515 obo:IAO_0000115 "The thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints." ; obo:UBPROP_0000007 "periosteal" ; oboInOwl:hasDbXref "BTO:0001022", "EMAPA:35681", "FMA:24041", "GAID:925", "MA:0002838", "MESH:D010521", "NCIT:C13184", "SCTID:33840008", "UMLS:C0031110", "Wikipedia:Periosteum", "galen:PeriOsteum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002515" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "periosteum" ; rdfs:subClassOf obo:UBERON_0000158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011822 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png"^^xsd:anyURI . obo:UBERON_0002516 obo:IAO_0000115 "A hyaline cartilage plate in the metaphysis at each end of a long bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line." ; obo:IAO_0000116 "consider splitting this class into the epiphyseal plates of long bones and vertebrae" ; oboInOwl:hasDbXref "BTO:0000412", "EMAPA:35505", "FMA:75427", "GAID:191", "MA:0002839", "MESH:D006132", "SCTID:84349008", "Wikipedia:Epiphyseal_plate" ; oboInOwl:hasExactSynonym "epiphyseal growth plate", "epiphyseal growth plate cartilage", "epiphysial plate", "long bone epiphyseal plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilago epiphysialis", "epiphyseal cartilage", "epiphyseal disk", "epiphyseal growth disk", "growth plate", "lamina epiphysialis", "physis" ; oboInOwl:id "UBERON:0002516" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "epiphyseal plate" ; rdfs:subClassOf obo:UBERON_0001994, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001438 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7a/Tib_fib_growth_plates.jpg"^^xsd:anyURI . obo:UBERON_0002517 obo:IAO_0000115 "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." ; obo:UBPROP_0000007 "basicranial" ; oboInOwl:hasDbXref "FMA:52801", "MA:0002840", "MESH:D019291", "MFMO:0000044", "NCIT:C12493", "SCTID:181890004", "UMLS:C0149543", "Wikipedia:Base_of_skull" ; oboInOwl:hasExactSynonym "base of cranium", "base of skull", "basis cranii", "cranial base" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002517" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816]" ; rdfs:label "basicranium" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003128 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png"^^xsd:anyURI . obo:UBERON_0002521 obo:IAO_0000115 "Connective tissue composed of elastic fibers." ; oboInOwl:hasDbXref "FMA:20113", "GAID:926", "MA:0002853", "MESH:D004547", "NCIT:C32495", "SCTID:27197004", "Wikipedia:Elastic_fiber" ; oboInOwl:hasExactSynonym "elastic connective tissue", "textus connectivus elasticus" ; oboInOwl:hasNarrowSynonym "elastic fiber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002521" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001171 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0071953 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png"^^xsd:anyURI . obo:UBERON_0002522 obo:IAO_0000115 "The middle layer of an artery or vein. [WP,unvetted]." ; oboInOwl:hasDbXref "BTO:0002011", "EMAPA:36298", "FMA:55590", "GAID:170", "MA:0002855", "MESH:D017540", "NCIT:C33821", "SCTID:61695000", "UMLS:C0162867", "Wikipedia:Tunica_media" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tunica media vasorum" ; oboInOwl:id "UBERON:0002522" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "May be composed of smooth muscle and elastic tissue" ; rdfs:label "tunica media" ; rdfs:subClassOf obo:UBERON_0004797, [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0005734 ], _:genid125537, _:genid125539 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg"^^xsd:anyURI . obo:UBERON_0002523 obo:IAO_0000115 "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." ; obo:IAO_0000116 "the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure", "the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts" ; obo:UBPROP_0000001 "The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia]" ; oboInOwl:hasDbXref "BTO:0002012", "EMAPA:36297", "FMA:55589", "GAID:523", "MA:0002861", "MESH:D017539", "NCIT:C33820", "SCTID:8361002", "SCTID:87483006", "UMLS:C0162864", "Wikipedia:Tunica_intima" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Bichat's tunic", "intima", "tunica intima vasorum" ; oboInOwl:id "UBERON:0002523" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "tunica intima" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001986 ], _:genid125547, _:genid125549 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg"^^xsd:anyURI . obo:UBERON_0002527 obo:IAO_0000115 "A lymph node that is part of a pancreas [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:16626", "MA:0002881", "NCIT:C77642", "SCTID:276170003", "UMLS:C0229783" ; oboInOwl:hasExactSynonym "lymph node of pancreas", "pancreas lymph node", "pancreatic node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aJCC level 19 node", "pyloric lymph node" ; oboInOwl:id "UBERON:0002527" ; a owl:Class ; rdfs:label "pancreatic lymph node" ; rdfs:subClassOf obo:UBERON_0002507 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0002528 obo:IAO_0000115 "A lymph node located in the sacral region." ; oboInOwl:hasDbXref "FMA:16655", "MA:0002883", "NCIT:C77647", "SCTID:279797001", "UMLS:C0229827", "Wikipedia:Sacral_lymph_nodes" ; oboInOwl:hasExactSynonym "sacral node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002528" ; a owl:Class ; rdfs:label "sacral lymph node" ; rdfs:subClassOf obo:UBERON_8470001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid124606 ] . obo:UBERON_0002529 obo:IAO_0000115 "A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles." ; obo:IAO_0000116 "TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition" ; obo:UBPROP_0000012 "FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z" ; oboInOwl:hasDbXref "FMA:241863", "MA:0002889", "NCIT:C38630", "UMLS:C1268195" ; oboInOwl:hasExactSynonym "free limb segment", "segment of limb", "subdivision of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extremity part", "limb region", "region of limb" ; oboInOwl:id "UBERON:0002529" ; a owl:Class ; rdfs:label "limb segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0014892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_0010912 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010758 _:genid124613 ) ] . obo:UBERON_0002530 obo:IAO_0000115 "An organ that functions as a secretory or excretory organ." ; obo:RO_0002171 obo:UBERON_0001434 ; obo:UBPROP_0000007 "glandular" ; oboInOwl:hasDbXref "AAO:0000212", "AEO:0000096", "BTO:0000522", "EFO:0000797", "EHDAA2:0003096", "EHDAA:2161", "EHDAA:4475", "EHDAA:6522", "EMAPA:18425", "FBbt:00100317", "FMA:7146", "FMA:86294", "HAO:0000375", "MA:0003038", "MAT:0000021", "MIAA:0000021", "NCIT:C13319", "SCTID:134358001", "UMLS:C1285092", "Wikipedia:Gland", "WikipediaCategory:Glands", "galen:Gland" ; oboInOwl:hasExactSynonym "glandular organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Druese", "glandula" ; oboInOwl:id "UBERON:0002530" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "gland" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046903 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0000463 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png"^^xsd:anyURI . obo:UBERON_0002532 obo:IAO_0000115 "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." ; obo:IAO_0000116 "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" ; obo:UBPROP_0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" ; oboInOwl:hasDbXref "BTO:0004593", "FMA:296704", "MAT:0000067", "MIAA:0000067", "VHOG:0000243", "Wikipedia:Epiblast" ; oboInOwl:hasExactSynonym "epiblast" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blastocyst", "ectoblast", "epiblastus", "primitive ectoderm" ; oboInOwl:id "UBERON:0002532" ; oboInOwl:inSubset core:early_development, core:grouping_class, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "epiblast (generic)" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000352 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png"^^xsd:anyURI . obo:UBERON_0002533 obo:IAO_0000115 "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." ; obo:IAO_0000116 "See notes from https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; obo:UBPROP_0000001 "Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (5) a larva or embryo with a postanal tail.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011104", "BTO:0001445", "EFO:0002748", "EHDAA2:0001976", "EHDAA:1595", "EMAPA:16580", "MAT:0000070", "MIAA:0000070", "TAO:0000077", "VHOG:0000201", "XAO:0000107", "ZFA:0000077" ; oboInOwl:hasExactSynonym "tail bud", "tailbud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "end bud", "tail bud mesenchyme" ; oboInOwl:id "UBERON:0002533" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "post-anal tail bud" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0007812 ] . obo:UBERON_0002537 obo:IAO_0000115 "A gonad with both testicular and ovarian aspects[WP]." ; oboInOwl:hasDbXref "BTO:0000981", "EFO:0000971", "MAT:0000165", "MIAA:0000165", "WBbt:0005178", "Wikipedia:Ovotestis" ; oboInOwl:hasExactSynonym "hermaphrodite genitalia" ; oboInOwl:hasNarrowSynonym "glandula hermaphroditica", "hermaphrodite gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ovotestis" ; oboInOwl:id "UBERON:0002537" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "hermaphrodite gonad" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007197 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000991 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007283 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0048477 ] ) ] . obo:UBERON_0002539 obo:IAO_0000115 "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." ; obo:UBPROP_0000001 "One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG]" ; obo:UBPROP_0000013 "Numbered cranial to caudal. different in mammals. branchial arch = ZFA:0001613 pharyngeal arch 3-7. generally gill arch 1 = pharyngeal arch 3. terminology varies as to whether branchial arch follows gill or pharyngeal numbering" ; oboInOwl:hasDbXref "AAO:0010359", "BTO:0001785", "EFO:0000959", "EHDAA:571", "EMAPA:16117", "FMA:293015", "GAID:1292", "MAT:0000242", "MESH:D001934", "MIAA:0000242", "NCIT:C34249", "SCTID:308766004", "TAO:0001306", "UMLS:C0080322", "VHOG:0000155", "Wikipedia:Pharyngeal_arch", "XAO:0000096", "ZFA:0001306" ; oboInOwl:hasExactSynonym "pharyngeal arches" ; oboInOwl:hasNarrowSynonym "branchial arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcus pharyngei", "visceral arch" ; oboInOwl:id "UBERON:0002539" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch" ; rdfs:subClassOf obo:UBERON_0000481, obo:UBERON_0010188, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008814 ], _:genid125620, _:genid125622, _:genid125624 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png"^^xsd:anyURI . obo:UBERON_0002544 obo:IAO_0000115 "A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans)." ; obo:IAO_0000232 "this class represents the entire organism subdivision encompassing soft tissue as well as the underlying skeletal framework. The class represents the phalangeal part only - historically the term 'digit' has also been used to represent the unit consisting of a series of phalanges together with a metapodial bone. We may in future relabel this class to avoid confusion with this concept, but the class will continue to represent the phalangeal portion" ; obo:RO_0002171 obo:UBERON_0009877 ; obo:UBPROP_0000003 "Our reinterpretation of the distal fin endoskeleton of Panderichthys removes the final piece of evidence supporting the formerly popular hypothesis that tetrapod digits are wholly new structures without homologues in sarcopterygian fish fins. This hypothesis, which was based partly on the complete absence of plausible digit homologues in Panderichthys (then the closest known relative of tetrapods), has already been called into question by the discovery of digit-like radials in Tiktaalik and the fact that Hox gene expression patterns closely resembling those associated with digit formation in tetrapods occur in the distal fin skeletons of paddlefish and Australian lungfish. Our new data show that Panderichthys is not an anomaly: like Tiktaalik and other fish members of the Tetrapodomorpha, it has distal radials that can be interpreted as digit homologues.[well established][VHOG]" ; obo:UBPROP_0000007 "digital" ; oboInOwl:hasDbXref "AAO:0011126", "EFO:0000881", "EMAPA:32725", "FMA:85518", "MA:0000690", "MAT:0000285", "MIAA:0000285", "NCIT:C40186", "SCTID:361367007", "UMLS:C0582802", "VHOG:0000944", "Wikipedia:Digit_(anatomy)", "XAO:0003032", "galen:Digit" ; oboInOwl:hasExactSynonym "acropodial unit", "digit (phalangeal portion) plus soft tissue", "limb digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002544" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "digit" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5002544 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0015023 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002470 ], _:genid125637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005881 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012354 ] ) ] . obo:UBERON_0002546 obo:IAO_0000115 "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." ; obo:IAO_0000116 "Do not merge with neurogenic placode" ; obo:UBPROP_0000008 "Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons" ; obo:UBPROP_0000013 "The term placode or placodes also applies to developing organs such as teeth, mammary glands, hair follicles, feathers and scales. We include a separate parent class for this. to avoid confusion, we include neurogenic placode as a subclass" ; oboInOwl:hasBroadSynonym "ectodermal placode", "placode" ; oboInOwl:hasDbXref "AAO:0010466", "EFO:0001650", "FMA:293966", "MAT:0000369", "MIAA:0000369", "XAO:0000305" ; oboInOwl:hasExactSynonym "ectodermal cranial placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial placodes" ; oboInOwl:id "UBERON:0002546" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "cranial placode" ; rdfs:subClassOf obo:UBERON_0005085, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] . obo:UBERON_0002553 obo:IAO_0000115 "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." ; oboInOwl:hasBroadSynonym "cavity" ; oboInOwl:hasDbXref "BIRNLEX:1011", "EMAPA:37442", "FMA:67552", "MA:0002447", "NCIT:C34007", "galen:Cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002553" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "anatomical cavity" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000463 ] . obo:UBERON_0002558 oboInOwl:hasDbXref "BIRNLEX:1019", "FMA:12237", "SCTID:362606005" ; oboInOwl:hasExactSynonym "cavity of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002558" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "organ cavity" ; rdfs:subClassOf obo:UBERON_0002553 . obo:UBERON_0002561 obo:IAO_0000115 "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." ; obo:RO_0002175 obo:NCBITaxon_569425 ; oboInOwl:hasDbXref "BIRNLEX:1029", "FMA:75007" ; oboInOwl:hasExactSynonym "cavity of neuraxis", "cavity of ventricular system of neuraxis", "neuraxis cavity", "neuraxis lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002561" ; a owl:Class ; rdfs:label "lumen of central nervous system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002558 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0002567 obo:IAO_0000115 "Ventral subdivision of the pons which consists of the massive pontine pertuberance on pontine ventral surface." ; oboInOwl:hasDbXref "BAMS:Bpons", "BIRNLEX:1043", "DHBA:12405", "FMA:72244", "HBA:9132", "SCTID:361541001", "UMLS:C0228427", "Wikipedia:Basilar_part_of_pons", "neuronames:616" ; oboInOwl:hasExactSynonym "basal portion of pons", "base of pons", "basilar part of pons", "pars basilaris pontis", "pons proper", "ventral pons", "ventral portion of pons" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal part of the pons", "basilar pons", "basis pontis", "pars anterior pontis", "pars ventralis pontis" ; oboInOwl:id "UBERON:0002567" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "basal part of pons" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988 ], _:genid124705 . obo:UBERON_0002588 obo:IAO_0000115 "Regional part of superior cerebellar peduncle located in the caudal midbrain, at the level of the inferior colliculus, consisting of a large bundle of fibers crossing the midline. It contains fibers projecting from the deep cerebellar nucleus to the midbrain and thalamus through the superior cerebellar peduncle (MM). The decussation of superior cerebellar peduncle is the portion of the superior cerebellar peduncle which crosses into the midbrain. [WP,unvetted]." ; oboInOwl:hasAlternativeId "UBERON:0003032" ; oboInOwl:hasDbXref "BAMS:dscp", "BAMS:xscp", "BIRNLEX:1089", "BM:BCX", "DHBA:12337", "FMA:72455", "HBA:265505482", "MBA:812", "SCTID:369252009", "UMLS:C0152374", "Wikipedia:Decussation_of_superior_cerebellar_peduncle", "neuronames:527" ; oboInOwl:hasExactSynonym "Wernekink's decussation", "decussatio pedunculorum cerebellarium superiorum", "decussation of brachium conjunctivum", "decussation of superior cerebellar peduncles", "superior cerebellar peduncle decussation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "decussatio brachii conjunctivi", "decussatio crurorum cerebello-cerebralium", "decussation of the superior cerebellar peduncle", "decussation of the superior cerebellar peduncle (Wernekinck)", "descussation of the scp" ; oboInOwl:id "UBERON:0002588" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "decussation of superior cerebellar peduncle" ; rdfs:subClassOf _:genid125690 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002150 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/26/Gray711.png"^^xsd:anyURI . obo:UBERON_0002589 obo:IAO_0000115 "Part of the corticospinal tract located in the spinal cord, formed as 75 to 90% of the corticospinal fibers cross to the opposite side of the brainstem in the pyramidal decussation. This tract descends the length of the spinal cord in the lateral white column (Adapted from Brain Info)." ; oboInOwl:hasDbXref "BAMS:lcsp", "BAMS:py", "BIRNLEX:1095", "DHBA:12759", "EMAPA:37888", "FMA:72635", "MBA:1019", "NCIT:C32406", "SCTID:369091005", "UMLS:C0152402", "Wikipedia:Lateral_corticospinal_tract", "neuronames:801" ; oboInOwl:hasExactSynonym "corticospinal tract, crossed", "crossed pyramidal tract", "lateral pyramidal tract", "pyramidal tract, crossed" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corticospinal tract, crossed", "crossed corticospinal tract", "fasciculus cerebrospinalis lateralis", "lateral corticospinal tract", "lateral corticospinal tract of the medulla", "tractus corticospinalis (pyramidalis) lateralis", "tractus corticospinalis lateralis" ; oboInOwl:id "UBERON:0002589" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lateral corticospinal tract" ; rdfs:subClassOf obo:UBERON_0007702, _:genid125706, _:genid125708 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Spinal_cord_tracts_-_English.svg"^^xsd:anyURI . obo:UBERON_0002600 obo:IAO_0000115 "Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem." ; oboInOwl:hasDbXref "BAMS:LL", "BAMS:Limbic_lobe", "BIRNLEX:1128", "CALOHA:TS-2061", "DHBA:12155", "FMA:72719", "HBA:4219", "MESH:D065726", "SCTID:279215006", "UMLS:C0458337", "Wikipedia:Limbic_lobe", "neuronames:834" ; oboInOwl:hasExactSynonym "fornicate gyrus", "grande lobe limbique of Broca", "limbic lobe (carpenter)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fornicate convolution", "fornicate lobe", "gyrus fornicatus", "lobus limbicus" ; oboInOwl:id "UBERON:0002600" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "limbic lobe" ; rdfs:subClassOf obo:UBERON_0016526 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Human_brain_inferior-medial_view_description.JPG"^^xsd:anyURI . obo:UBERON_0002610 obo:IAO_0000115 "The cochlear nuclei consist of: (a) the dorsal cochlear nucleus, corresponding to the tuberculum acusticum on the dorso-lateral surface of the inferior peduncle; and (b) the ventral or accessory cochlear nucleus, placed between the two divisions of the nerve, on the ventral aspect of the inferior peduncle. [WP,unvetted]." ; obo:RO_0002171 obo:UBERON_0002126, obo:UBERON_0002162, obo:UBERON_0002591, obo:UBERON_0002864, obo:UBERON_0002866, obo:UBERON_0002873, obo:UBERON_0007633 ; obo:UBPROP_0000015 "WP says 'The CN is located at the dorso-lateral side of the brainstem, spanning the junction of the pons and medulla.'. MA places this in pons, other sources the medulla" ; oboInOwl:hasDbXref "BAMS:CN", "BIRNLEX:1151", "BM:Me-Co", "DHBA:12437", "EV:0100260", "FMA:72240", "HBA:9528", "MBA:607", "UMLS:C0152411", "Wikipedia:Cochlear_nuclei", "neuronames:720" ; oboInOwl:hasExactSynonym "cochlear nuclei" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei cochleares" ; oboInOwl:id "UBERON:0002610" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "cochlear nuclear complex" ; rdfs:subClassOf obo:UBERON_0002020, _:genid125733 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png"^^xsd:anyURI . obo:UBERON_0002616 obo:IAO_0000115 "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." ; oboInOwl:hasDbXref "BIRNLEX:1167", "FMA:55676", "NCIT:C13031", "SCTID:384763002", "UMLS:C0445620" ; oboInOwl:hasExactSynonym "anatomical structure of brain", "biological structure of brain", "brain anatomical structure", "brain biological structure", "brain part", "neuraxis segment", "neuroanatomical region", "segment of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002616" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "regional part of brain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0003714 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0002663 obo:IAO_0000115 "Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone)." ; obo:UBPROP_0000001 "Any of the groups of neural nuclei situated in the septal region which have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala.", "The septal nuclei are structures in the middle anteroventral cerebrum that are composed of medium-size neurons grouped into medial, lateral, and posterior groups. The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens. In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly in order to experience a euphoric feeling (i.e. press a bar to receive electrical current that will stimulate the neurons). [WP,unvetted][Wikipedia:Septal_nuclei]." ; obo:UBPROP_0000012 "in NIFSTD this is the mereological sum of the individual complexes - in MA it is the superclass" ; oboInOwl:hasDbXref "BAMS:SptN", "BIRNLEX:1313", "DHBA:10350", "EHDAA2:0004709", "EMAPA:35763", "FMA:61845", "GAID:637", "HBA:13002", "MA:0002978", "MESH:D012686", "UMLS:C0036687", "Wikipedia:Septal_nuclei", "neuronames:259" ; oboInOwl:hasExactSynonym "parolfactory nuclei", "septal nuclei", "septal nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei septales" ; oboInOwl:id "UBERON:0002663" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "septal nuclear complex" ; rdfs:subClassOf _:genid125764 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007245 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000446 ] ) ] . obo:UBERON_0002673 obo:IAO_0000115 "Nuclear complex containing the vestibular nuclei." ; obo:IAO_0000116 "In TA they are grouped in both the pons and medulla; DHBA has 'vestibular nuclei of pons', with LVN and SVN underneath; WP+MA says the SVN is in the pons, and GO includes VNC development under pons development, but this is not supported by ABA. Todo - check with NIF." ; obo:RO_0002171 obo:UBERON_0001719, obo:UBERON_0002127, obo:UBERON_0002154, obo:UBERON_0002155, obo:UBERON_0002559, obo:UBERON_0002870, obo:UBERON_0002871, obo:UBERON_0002872, obo:UBERON_0002877 ; oboInOwl:hasDbXref "BAMS:VNC", "BAMS:Ve", "BIRNLEX:1337", "BM:Me-VS", "BTO:0004368", "CALOHA:TS-2078", "EV:0100254", "FMA:72239", "GAID:602", "HBA:9697", "MBA:701", "MESH:D014726", "UMLS:C0042600", "Wikipedia:Vestibular_nuclei", "neuronames:714" ; oboInOwl:hasExactSynonym "nuclei vestibulares in medulla oblongata", "vestibular nuclei", "vestibular nuclei in medulla oblongata" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei vestibulares", "vestibular nucleus" ; oboInOwl:id "UBERON:0002673" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "vestibular nuclear complex" ; rdfs:subClassOf obo:UBERON_0007245, _:genid125775, _:genid125777 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png"^^xsd:anyURI . obo:UBERON_0002682 obo:IAO_0000115 "Nucleus located beneath the floor of the 4th ventricle in the pontine tegmentum, containing motor neurons innervating the lateral rectus muscle of the eye (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533)." ; obo:RO_0002171 obo:UBERON_0002143, obo:UBERON_0002147, obo:UBERON_0002149, obo:UBERON_0002633, obo:UBERON_0002963, obo:UBERON_0003011, obo:UBERON_0007632 ; obo:UBPROP_0000001 "Hindbrain motor nucleus which is the origin of motor axons of cranial nerve VI. From Neuroanatomy of the Zebrafish Brain.[TAO]" ; obo:UBPROP_0000012 "part of medulla oblongata in ABA and ZFA; part of pons in MA and pontine tegmentum in NIF; note that pons/medulla are spatially disjoint in ABA." ; oboInOwl:hasDbXref "BAMS:6", "BAMS:VI", "BIRNLEX:1366", "BM:Pons-VI", "DHBA:12418", "DMBA:17279", "EHDAA2:0004310", "EMAPA:35105", "EV:0100266", "FMA:54504", "HBA:9136", "MA:0001010", "MBA:653", "MESH:D065827", "NCIT:C12836", "SCTID:280165008", "TAO:0000713", "UMLS:C0152407", "Wikipedia:Abducens_nucleus", "ZFA:0000713", "neuronames:585" ; oboInOwl:hasExactSynonym "abducens VI nucleus", "abducens motor nuclei", "abducens motor nucleus", "abducens nerve nucleus", "abducent nucleus", "motor nucleus VI", "nVI", "nucleus nervi abducentis", "nucleus of abducens nerve", "nucleus of abducens nerve (VI)", "sixth cranial nerve nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abducens nucleus proper", "nucleus abducens", "nucleus nervi abducentis" ; oboInOwl:id "UBERON:0002682" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "abducens nucleus" ; rdfs:subClassOf obo:UBERON_0000126, _:genid125797 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png"^^xsd:anyURI . obo:UBERON_0002707 obo:IAO_0000115 "The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract." ; oboInOwl:hasAlternativeId "UBERON:0004095" ; oboInOwl:hasBroadSynonym "pyramidal tract" ; oboInOwl:hasDbXref "BAMS:P", "BIRNLEX:1464", "BM:CST", "BM:Me-PyT", "DHBA:12776", "DMBA:17756", "EMAPA:36600", "FMA:72634", "GAID:702", "HBA:265505574", "MBA:190", "MBA:784", "MESH:D011712", "SCTID:362325000", "UMLS:C0034229", "Wikipedia:Corticospinal_tract", "neuronames:1320", "neuronames:800" ; oboInOwl:hasExactSynonym "corticospinal fibers", "fasciculus cerebro-spinalis", "fasciculus pyramidalis", "fibrae corticospinales", "pyramid (Willis)", "tractus cortico-spinalis", "tractus corticospinalis", "tractus pyramidalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002707" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "corticospinal tract" ; rdfs:subClassOf obo:UBERON_0001018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0025525 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036224 ], _:genid125826 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png"^^xsd:anyURI . obo:UBERON_0002722 obo:IAO_0000115 "Nucleus in the midbrain at the level of the inferior colliculus near the midline, containing the motor neurons giving rise to the trochlear nerve, innervating the contralateral superior oblique extraocular muscle of the eye (Brodal, Neurological Anatomy, 3rd ed, 1981, pg. 533)." ; obo:RO_0002171 obo:UBERON_0001715, obo:UBERON_0001944, obo:UBERON_0001947, obo:UBERON_0001966, obo:UBERON_0002141, obo:UBERON_0002438, obo:UBERON_0002691, obo:UBERON_0002696, obo:UBERON_0002995, obo:UBERON_0003040 ; oboInOwl:hasDbXref "BAMS:4", "BAMS:4N", "BAMS:IV", "BIRNLEX:1488", "BM:MB-IV", "DHBA:12206", "DMBA:16903", "EMAPA:35886", "EV:0100251", "FMA:54518", "HBA:9063", "MA:0001075", "MBA:115", "SCTID:280163001", "TAO:0000450", "UMLS:C0152406", "Wikipedia:Trochlear_nucleus", "ZFA:0000450", "neuronames:513" ; oboInOwl:hasExactSynonym "fourth cranial nerve nucleus", "motor nucleus IV", "nIV", "nucleus nervi trochlearis", "nucleus of trochlear nerve", "trochlear IV nucleus", "trochlear motor nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus nervi trochlearis" ; oboInOwl:id "UBERON:0002722" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trochlear nucleus" ; rdfs:subClassOf obo:UBERON_0000126, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001943 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001644 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Drn.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/en/thumb/c/c6/Drn.png/200px-Drn.png"^^xsd:anyURI . obo:UBERON_0002726 obo:IAO_0000115 "A spinal cord segment that adjacent_to a cervical region." ; oboInOwl:hasDbXref "BIRNLEX:1499", "FMA:71166", "MA:0003081", "NCIT:C12892", "SCTID:180960003", "UMLS:C0581619", "UMLS:C1278837", "neuronames:1654" ; oboInOwl:hasExactSynonym "cervical segment of spinal cord", "cervical segments of spinal cord [1-8]", "cervical spinal cord", "pars cervicalis medullae spinalis", "segmenta cervicalia medullae spinalis [1-8" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002726" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005844 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005434 ] ) ] . obo:UBERON_0002742 obo:IAO_0000115 "One of two layers of both white and gray matter of the septum pellucidum. During fetal development there is a space between the two laminae called the cavum septum pellucidum which, in ninety per cent of cases, disappears during infancy." ; obo:UBPROP_0000012 "FMA classifies as white matter" ; oboInOwl:hasDbXref "BAMS:lsp", "BIRNLEX:1554", "FMA:62472", "SCTID:12164006", "UMLS:C0152278", "Wikipedia:Septum_pellucidum#Layers", "neuronames:258" ; oboInOwl:hasExactSynonym "laminae septi pellucidi", "septum pellucidum lamina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lamina of the septum pellucidum", "lamina septi pellucidi" ; oboInOwl:id "UBERON:0002742" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lamina of septum pellucidum" ; rdfs:subClassOf obo:UBERON_0022303, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002020 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002316 ], _:genid125877 . obo:UBERON_0002743 obo:IAO_0000115 "A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert." ; oboInOwl:hasDbXref "BAMS:Basal_forebrain", "BIRNLEX:1560", "BM:Tel-BF", "BTO:0002444", "DHBA:10349", "EMAPA:35164", "FMA:77700", "HBA:4300", "MESH:D066187", "PBA:128012976", "Wikipedia:Basal_forebrain", "neuronames:1997" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal forebrain area", "pars basalis telencephali" ; oboInOwl:id "UBERON:0002743" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "basal forebrain" ; rdfs:subClassOf obo:UBERON_0002616, _:genid125889 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png"^^xsd:anyURI . obo:UBERON_0002749 obo:IAO_0000115 "A regional part of brain that is part of a cerebellar cortex [Automatically generated definition]." ; oboInOwl:hasDbXref "BIRNLEX:1571", "FMA:76924" ; oboInOwl:hasExactSynonym "cerebellar cortical segment", "segment of cerebellar cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002749" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "regional part of cerebellar cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002129 ] ) ] . obo:UBERON_0002787 obo:IAO_0000115 "The crossing of the two trochlear nerves at their exit through the velum medullare anterius." ; oboInOwl:hasDbXref "BAMS:4x", "BAMS:IVd", "BIRNLEX:1690", "DHBA:12338", "FMA:72488", "MBA:384", "UMLS:C0175448", "neuronames:595" ; oboInOwl:hasExactSynonym "decussatio fibrarum nervorum trochlearium", "decussation of trochlear nerve (IV)", "decussation of trochlear nerve fibers", "trochlear neural decussation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "decussatio nervorum trochlearium", "decussatio trochlearis", "decussation of the trochlear nerve", "trochlear decussation", "trochlear nerve decussation" ; oboInOwl:id "UBERON:0002787" ; a owl:Class ; rdfs:label "decussation of trochlear nerve" ; rdfs:subClassOf _:genid125906 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007418 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001644 ] ) ] . obo:UBERON_0002792 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "BIRNLEX:1704", "FMA:71168", "MA:0003083", "NCIT:C12895", "SCTID:180962006", "UMLS:C0581620", "UMLS:C0581621", "UMLS:C1278838", "Wikipedia:Lumbar_spinal_cord", "neuronames:1677" ; oboInOwl:hasExactSynonym "lumbar segment of spinal cord", "lumbar segments of spinal cord [1-5]", "lumbar spinal cord", "pars lumbalis medullae spinalis", "segmenta lumbalia medullae spinalis [1-5]", "spinal cord lumbar segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002792" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "lumbar spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 ] ) ] . obo:UBERON_0002802 obo:IAO_0000115 "Parietal lobe of the left hemisphere of the brain." ; obo:RO_0002171 obo:UBERON_0002803 ; oboInOwl:hasDbXref "BIRNLEX:1728", "FMA:72974", "SCTID:314147009", "UMLS:C1281960" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002802" ; a owl:Class ; rdfs:label "left parietal lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002921 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid124957 ] . obo:UBERON_0002803 obo:IAO_0000115 "Parietal lobe of the right hemisphere of the brain." ; oboInOwl:hasDbXref "BIRNLEX:1729", "FMA:72973", "SCTID:314146000", "UMLS:C1281959" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002803" ; a owl:Class ; rdfs:label "right parietal lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002921 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001872 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ] . obo:UBERON_0002804 obo:IAO_0000115 "A limbic lobe that is part of a left cerebral hemisphere." ; oboInOwl:hasDbXref "BIRNLEX:1780", "FMA:72981" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002804" ; a owl:Class ; rdfs:label "left limbic lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002600 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 ] ) ] . obo:UBERON_0002805 obo:IAO_0000115 "A limbic lobe that is part of a right cerebral hemisphere." ; oboInOwl:hasDbXref "BIRNLEX:1781", "FMA:72980" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002805" ; a owl:Class ; rdfs:label "right limbic lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002600 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ] . obo:UBERON_0002808 obo:IAO_0000115 "A temporal lobe that is part of a left cerebral hemisphere." ; oboInOwl:hasDbXref "BIRNLEX:1784", "FMA:72972", "SCTID:314158000", "UMLS:C1281971" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002808" ; a owl:Class ; rdfs:label "left temporal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 ] ) ] . obo:UBERON_0002809 obo:IAO_0000115 "A temporal lobe that is part of a right cerebral hemisphere." ; oboInOwl:hasDbXref "BIRNLEX:1785", "FMA:72971", "SCTID:314157005", "UMLS:C1281970" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002809" ; a owl:Class ; rdfs:label "right temporal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001871 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ] . obo:UBERON_0002810 obo:IAO_0000115 "A frontal cortex that is part of a right cerebral hemisphere." ; oboInOwl:hasDbXref "BIRNLEX:1786", "FMA:72969", "SCTID:314141005", "UMLS:C1281954" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002810" ; a owl:Class ; rdfs:label "right frontal lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002921 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001870 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ] . obo:UBERON_0002811 obo:IAO_0000115 "A frontal cortex that is part of a left cerebral hemisphere." ; obo:RO_0002171 obo:UBERON_0002810 ; oboInOwl:hasDbXref "BIRNLEX:1787", "FMA:72970", "SCTID:314142003", "UMLS:C1281955" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002811" ; a owl:Class ; rdfs:label "left frontal lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002921 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001870 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 ] ) ] . obo:UBERON_0002812 obo:IAO_0000115 "A cerebral hemisphere that is in the left side of a brain." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "BIRNLEX:1795", "FMA:61819", "NCIT:C32955", "SCTID:362323007", "UMLS:C0228176" ; oboInOwl:hasExactSynonym "left hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002812" ; a owl:Class ; rdfs:label "left cerebral hemisphere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001869 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0002813 obo:IAO_0000115 "A cerebral hemisphere that is in the right side of a brain." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "BIRNLEX:1797", "FMA:67292", "NCIT:C33472", "SCTID:362322002", "UMLS:C0228175" ; oboInOwl:hasExactSynonym "right hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002813" ; a owl:Class ; rdfs:label "right cerebral hemisphere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001869 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0002824 obo:IAO_0000115 "The ganglion of the vestibular nerve. It contains the cell bodies of the bipolar primary afferent neurons whose peripheral processes form synaptic contact with hair cells of the vestibular sensory end organs[WP,unvetted]. Distributed to the maculae of the utricle and saccule and to the ampullary crests of the semicircular ducts. The vestibular fibers arise in bipolar cells in the vestibular ganglion in the internal acoustic meatus." ; oboInOwl:hasDbXref "BAMS:GvVIII", "BIRNLEX:2549", "EMAPA:17573", "FMA:53435", "MA:0001086", "NCIT:C33870", "RETIRED_EHDAA2:0002199", "SCTID:244450009", "UMLS:C0036286", "UMLS:C0446706", "VHOG:0000682", "Wikipedia:Scarpa%27s_ganglion", "neuronames:495" ; oboInOwl:hasExactSynonym "Scarpa's ganglion", "vestibular part of vestibulocochlear ganglion", "vestibulocochlear VIII ganglion vestibular component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus nervi oculomotorii, pars medialis", "vestibulocochlear ganglion vestibular component" ; oboInOwl:id "UBERON:0002824" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "vestibular ganglion" ; rdfs:subClassOf obo:UBERON_0001800, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001862 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002827 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004681 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0003723 ] ) ] . obo:UBERON_0002827 obo:IAO_0000115 "The group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia." ; obo:IAO_0000116 "Consider follow MA naming scheme." ; obo:UBPROP_0000001 "The sensory ganglion of the ear. (See Anatomical Atlas entry for statoacoustic ganglion by T. Whitfield.)[TAO]" ; obo:UBPROP_0000003 "(During the development of the inner ear in a vertebrate embryo) As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII.[well established][VHOG]" ; obo:UBPROP_0000013 "The cell bodies of the cochlear nerve lie within the central aspect of the cochlea and are collectively known as the spiral ganglion. This name reflects the fact that the cell bodies, considered as a unit, have a spiral (or perhaps more accurately, a helical) shape, reflecting the shape of the cochlea. The terms 'cochlear nerve fiber' and 'spiral ganglion cell' are used, to some degree, interchangeably, although the former may be used to more specifically refer to the central axons of the cochlear nerve. These central axons exit the cochlea at its base, where it forms a nerve trunk. In humans, this aspect of the nerve is roughly one inch in length. It projects centrally to the brainstem, where its fibers synapse with the cell bodies of the cochlear nucleus" ; oboInOwl:hasBroadSynonym "SAG" ; oboInOwl:hasDbXref "BIRNLEX:2564", "EFO:0003543", "EHDAA2:0002196", "EHDAA:5569", "EHDAA:6653", "EMAPA:16982", "EMAPA:17571", "MA:0001084", "TAO:0000588", "UMLS:C0037959", "VHOG:0000696", "XAO:0004142", "ZFA:0000588", "neuronames:496" ; oboInOwl:hasExactSynonym "acoustic ganglion VIII", "acoustico-vestibular VIII ganglion", "auditory ganglion", "gVIII", "ganglion VIII", "statoacoustic (VIII) ganglion", "statoacoustic ganglia", "statoacoustic ganglion", "vestibulocochlear VIII ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acoustic ganglion", "auditory ganglion", "nucleus nervi oculomotorii ventrolateralis", "nucleus nervi oculomotorii, pars ventralis", "statoacoustic VIII ganglion", "vestibulocochlear ganglia" ; oboInOwl:id "UBERON:0002827" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vestibulocochlear ganglion" ; rdfs:subClassOf obo:UBERON_0001714, _:genid126016, _:genid126018, _:genid126020, _:genid126022 . obo:UBERON_0002871 obo:IAO_0000115 "Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453)." ; obo:RO_0002171 obo:UBERON_0001719, obo:UBERON_0002127, obo:UBERON_0002154, obo:UBERON_0002155, obo:UBERON_0002559, obo:UBERON_0002673, obo:UBERON_0002870, obo:UBERON_0002872, obo:UBERON_0002877 ; oboInOwl:hasDbXref "BAMS:12", "BAMS:12N", "BAMS:XII", "BIRNLEX:2644", "BM:XII", "DHBA:12545", "EHDAA2:0004635", "EMAPA:35416", "EV:0100286", "FMA:54505", "HBA:9557", "MA:0001039", "MBA:773", "NCIT:C12899", "SCTID:47361005", "UMLS:C0228802", "VHOG:0001358", "Wikipedia:Hypoglossal_nucleus", "ncithesaurus:Nucleus_of_the_Hypoglossal_Nerve", "neuronames:757" ; oboInOwl:hasExactSynonym "hypoglossal XII nucleus", "hypoglossal nerve nucleus", "hypoglossal nucleus", "nucleus nervi hypoglossi", "nucleus of hypoglossal nerve", "twelfth cranial nerve nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus hypoglossalis", "nucleus nervi hypoglossi" ; oboInOwl:id "UBERON:0002871" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hypoglossal nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid125064 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png"^^xsd:anyURI . obo:UBERON_0002916 obo:IAO_0000115 "The central sulcus is a fold in the cerebral cortex of brains in vertebrates. Also called the central fissure, it was originally called the fissure of Rolando or the Rolandic fissure, after Luigi Rolando. The central sulcus is a prominent landmark of the brain, separating the parietal lobe from the frontal lobe and the primary motor cortex from the primary somatosensory cortex. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "CS" ; oboInOwl:hasDbXref "BAMS:cs", "BIRNLEX:4035", "BM:Tel-Cx-CS", "DHBA:10614", "FMA:83752", "HBA:9403", "NCIT:C32280", "SCTID:279340001", "UMLS:C0228188", "UMLS:C1281071", "Wikipedia:Central_sulcus", "neuronames:48" ; oboInOwl:hasExactSynonym "central cerebral sulcus", "central fissure", "central sulcus of Rolando", "fissure of Rolando", "rolandic fissure", "sulcus centralis", "sulcus centralis (rolandi)", "sulcus centralis cerebri", "sulcus of Rolando" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002916" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "central sulcus" ; rdfs:subClassOf _:genid126076 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013118 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001870 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001872 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray726_central_sulcus.svg"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/b/b6/Central_sulcus.png"^^xsd:anyURI . obo:UBERON_0002921 obo:IAO_0000115 "The deep groove which separates the two hemispheres of the vertebrate brain. The falx cerebri, a dural brain covering, lies within the medial longitudinal fissure. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "LF" ; oboInOwl:hasDbXref "BAMS:lf", "BAMS:lfh", "BIRNLEX:4041", "DHBA:10622", "FMA:83727", "HBA:9401", "NCIT:C33005", "SCTID:369225004", "UMLS:C0228186", "Wikipedia:Medial_longitudinal_fissure", "neuronames:35" ; oboInOwl:hasExactSynonym "fissura interhemispherica", "fissura longitudinalis cerebrales", "fissura longitudinalis cerebri", "fissura longitudinalis magna", "hemispheric sulcus", "interhemispheric fissure", "longitudinal cerebral fissure", "longitudinal fissure of hemisphere", "longitudinal fissure of the cerebrum", "longitudinal sulcus", "medial longitudinal fissure", "sagittal fissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002921" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "longitudinal fissure" ; rdfs:subClassOf obo:UBERON_0014466 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png"^^xsd:anyURI . obo:UBERON_0002925 obo:IAO_0000115 "A nucleus of brain that is part of a trigeminal nuclear complex." ; obo:UBPROP_0000012 "massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA." ; oboInOwl:hasDbXref "BM:V", "BTO:0001074", "CALOHA:TS-2077", "EMAPA:35883", "EV:0100271", "FMA:71247", "GAID:604", "MA:0001028", "MESH:D014278", "NCIT:C12807", "SCTID:280164007", "UMLS:C0040999", "VHOG:0001353", "http://uri.neuinfo.org/nif/nifstd/nifext_11" ; oboInOwl:hasExactSynonym "nucleus of trigeminal nuclear complex", "trigeminal V nucleus", "trigeminal nuclear complex nucleus", "trigeminal nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nucleus mesencephalicus nervi trigemini", "nucleus mesencephalicus trigeminalis", "nucleus tractus mesencephali nervi trigeminalis" ; oboInOwl:id "UBERON:0002925" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "trigeminal nucleus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001645 ] ; owl:equivalentClass _:genid125123 . obo:UBERON_0002926 obo:IAO_0000115 "A sensory epithelium that is part of a gustatory system." ; oboInOwl:hasDbXref "FMA:62412", "http://uri.neuinfo.org/nif/nifstd/nifext_12" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0002926" ; a owl:Class ; rdfs:label "gustatory epithelium" ; rdfs:subClassOf _:genid126126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006934 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 ] ) ] . obo:UBERON_0002956 obo:IAO_0000115 "The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." ; obo:RO_0002171 obo:UBERON_0002979 ; oboInOwl:hasDbXref "BIRNLEX:779", "BTO:0004425", "CALOHA:TS-1247", "EMAPA:35217", "FMA:83140", "MA:0000993", "MBA:1143", "NCIT:C49138", "UMLS:C1708253", "neuronames:363" ; oboInOwl:hasExactSynonym "cerebellar granular layer", "cerebellar granule cell layer", "cerebellar granule layer", "cerebellum granule cell layer", "cerebellum granule layer", "granule cell layer of cerebellar cortex", "stratum granulosum cerebelli", "stratum granulosum corticis cerebelli" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "granular layer of cerebellum" ; oboInOwl:id "UBERON:0002956" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "granular layer of cerebellar cortex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000119 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000555 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0001031 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004130 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001101 ; owl:someValuesFrom obo:UBERON_0002129 ] ) ] . obo:UBERON_0002988 oboInOwl:hasDbXref "FMA:37424", "SCTID:245003002" ; oboInOwl:hasExactSynonym "abductor indicis", "first dorsal interosseous of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "first dorsal interosseous muscle of hand" ; oboInOwl:id "UBERON:0002988" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "first dorsal interosseous of manus" ; rdfs:subClassOf obo:UBERON_0001503 . obo:UBERON_0003023 obo:IAO_0000115 "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." ; obo:UBPROP_0000009 "involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum]" ; oboInOwl:hasDbXref "BAMS:PTg", "BIRNLEX:923", "DHBA:12416", "FMA:71108", "HBA:9135", "MESH:D065821", "SCTID:362401009", "UMLS:C0228426", "Wikipedia:Pontine_tegmentum", "neuronames:557" ; oboInOwl:hasExactSynonym "dorsal pons", "dorsal portion of pons", "tegmental portion of pons", "tegmentum of pons", "tegmentum pontis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pars dorsalis pontis", "pars posterior pontis", "tegmentum pontis" ; oboInOwl:id "UBERON:0003023" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "pontine tegmentum" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002047 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002128 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002148 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002149 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png"^^xsd:anyURI . obo:UBERON_0003037 obo:IAO_0000115 "A wall, dividing a cavity or structure into smaller ones[WP]." ; obo:UBPROP_0000007 "septal" ; oboInOwl:hasDbXref "AAO:0011127", "FMA:86461", "Wikipedia:Septum" ; oboInOwl:hasExactSynonym "septa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003037" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "general anatomical term in FMA" ; rdfs:label "septum" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002553 ] . obo:UBERON_0003038 obo:IAO_0000115 "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." ; oboInOwl:hasDbXref "BIRNLEX:966", "FMA:71167", "MA:0003082", "NCIT:C12894", "SCTID:278750009", "UMLS:C0581620", "Wikipedia:Thoracic_spinal_cord", "neuronames:1718" ; oboInOwl:hasExactSynonym "pars thoracica medullae spinalis", "segmenta thoracica medullae spinalis [1-12]", "thoracic region of spinal cord", "thoracic segment of spinal cord", "thoracic segments of spinal cord [1-12]", "thoracic spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003038" ; oboInOwl:inSubset core:human_reference_atlas, core:uberon_slim ; a owl:Class ; rdfs:label "thoracic spinal cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008231 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png"^^xsd:anyURI . obo:UBERON_0003039 obo:IAO_0000115 "The horseshoe-shaped tract that connects the two olfactory bulbs." ; oboInOwl:hasBroadSynonym "pars anterior" ; oboInOwl:hasDbXref "BAMS:aca", "BAMS:aco", "BIRNLEX:969", "EMAPA:37404", "FMA:61963", "MBA:900", "neuronames:206" ; oboInOwl:hasExactSynonym "anterior commissure pars anterior", "anterior commissure, anterior part", "anterior part of anterior commissure", "commissura anterior, crus anterius", "commissura anterior, pars anterior", "commissura anterior, pars olfactoria", "commissura rostralis, pars anterior", "olfactory limb of anterior commissure", "olfactory part of anterior commissure", "pars anterior commissurae anterioris", "pars olfactoria commissurae anterioris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior commissure olfactory limb", "anterior commissure, olfactory limb" ; oboInOwl:id "UBERON:0003039" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anterior commissure anterior part" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000935 ] ; owl:disjointWith obo:UBERON_0003043, obo:UBERON_0006964 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 _:genid125199 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] . obo:UBERON_0003041 obo:IAO_0000115 "A nerve fiber that is part of a trigeminal nerve." ; oboInOwl:hasDbXref "BAMS:5nf", "BIRNLEX:974", "FMA:72501", "UMLS:C0175452", "neuronames:607" ; oboInOwl:hasExactSynonym "central part of trigeminal nerve", "trigeminal nerve fibers", "trigeminal nerve tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibrae nervi trigemini" ; oboInOwl:id "UBERON:0003041" ; a owl:Class ; rdfs:label "trigeminal nerve fibers" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001645 ] ) ] . obo:UBERON_0003043 obo:IAO_0000115 "The major forebrain commissure that connects the two temporal lobes of the cortex." ; oboInOwl:hasBroadSynonym "pars posterior" ; oboInOwl:hasDbXref "BAMS:acp", "BAMS:act", "BIRNLEX:977", "EMAPA:37410", "FMA:61964", "MBA:908", "UMLS:C0175210", "neuronames:207" ; oboInOwl:hasExactSynonym "anterior commissure pars posterior", "anterior commissure temporal limb", "anterior commissure, posterior part", "commissura anterior, crus posterius", "commissura anterior, pars posterior", "commissura rostralis, pars posterior", "pars posterior commissurae anterioris", "temporal limb of anterior commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior commissure, temporal limb" ; oboInOwl:id "UBERON:0003043" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior part of anterior commissure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002808 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002809 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000935 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000935 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001871 ] ) ] . obo:UBERON_0003050 obo:IAO_0000115 "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011076", "EFO:0003420", "EHDAA2:0001232", "EHDAA:1504", "EMAPA:16543", "FMA:293971", "TAO:0000048", "VHOG:0000186", "Wikipedia:Nasal_placode", "XAO:0000005", "ZFA:0000048" ; oboInOwl:hasExactSynonym "olfactory placodes", "placoda nasalis", "placoda olfactoria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal I placode", "nasal placode" ; oboInOwl:id "UBERON:0003050" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Olfactory placodes are the only ectodermal placodes to produce glia, a cell type typically derived from neural crest // Note that NBK53171 classifies this as non-neurogenic" ; rdfs:label "olfactory placode" ; rdfs:subClassOf obo:UBERON_0009955, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 ], _:genid126239 . obo:UBERON_0003051 obo:IAO_0000115 "An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP]." ; obo:UBPROP_0000001 "Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]", "One of the paired sacs of invaginated ectoderm that develop into the membranous labyrinth of the internal ear. [Biology_online][VHOG]" ; obo:UBPROP_0000003 "The inner ear develops embryonically in all vertebrates as an invagination of the ectodermal otic placode to form an otic vesicle.[well established][VHOG]" ; obo:UBPROP_0000012 "MP defines as epithelial sac, but EHDAA defines as multi-tissue; See https://github.com/obophenotype/uberon/issues/1305" ; oboInOwl:hasAlternativeId "UBERON:0004373" ; oboInOwl:hasDbXref "AAO:0011080", "BTO:0002661", "EHDAA2:0001342", "EMAPA:16669", "FMA:302920", "NCIT:C34240", "SCTID:308792006", "TAO:0000051", "UMLS:C1518678", "VHOG:0001148", "Wikipedia:Otic_vesicle", "XAO:0000006", "ZFA:0000051" ; oboInOwl:hasExactSynonym "otic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "OV", "acoustic vesicle", "auditory vesicle", "otocyst" ; oboInOwl:id "UBERON:0003051" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ear vesicle" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006273 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid125264 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray40.png"^^xsd:anyURI . obo:UBERON_0003052 obo:IAO_0000115 "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." ; obo:IAO_0000116 "consider adding class for organizer. Consider adding separate class for isthmus as a structure" ; obo:UBPROP_0000003 "Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011064", "DMBA:16810", "EHDAA2:0004395", "EHDAA:5789", "EMAPA:32857", "NCIT:C93172", "TAO:0000042", "VHOG:0000649", "XAO:0000016", "ZFA:0000042", "neuronames:2076" ; oboInOwl:hasExactSynonym "MHB", "mid-hindbrain boundary", "mid-hindbrain junction", "midbrain hindbrain boundary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "isthmic organizer territory", "isthmo-cerebellar region", "isthmus", "isthmus/MHB" ; oboInOwl:id "UBERON:0003052" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "midbrain-hindbrain boundary" ; rdfs:subClassOf obo:UBERON_0007651, _:genid126273, _:genid126275 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001891 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0003054 obo:IAO_0000115 "A single row of glia at the dorsal midline of the developing neural tube along the entire anterior-posterior axis. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." ; obo:IAO_0000116 "TODO - Note that although this is classically defined as being located on the neural tube, in many AOs the roof plate continues post-embryonically after the neural tube has ceased to exist. Consider 'roof plate of neural tube'. TODO - alar plate vs roof plate" ; obo:UBPROP_0000001 "Multi-tissue structure that is the dorsal-most aspect of the devleloping neural tube.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0003298" ; oboInOwl:hasDbXref "AAO:0011097", "EHDAA2:0001270", "EHDAA:2891", "EHDAA:916", "EMAPA:16168", "EMAPA:35361", "TAO:0001436", "TAO:0007058", "VHOG:0000303", "ZFA:0001436", "ZFA:0007058", "neuronames:1371" ; oboInOwl:hasExactSynonym "roof plate neural tube", "roof plate neural tube region", "roofplate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alar plate", "future brain roof plate" ; oboInOwl:id "UBERON:0003054" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "roof plate" ; rdfs:subClassOf obo:UBERON_0000119, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000125 ] . obo:UBERON_0003055 obo:IAO_0000115 "A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis." ; obo:UBPROP_0000001 "The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO]" ; obo:UBPROP_0000002 "relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO]" ; obo:UBPROP_0000008 "In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP]" ; obo:UBPROP_0000011 "In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis", "Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html)" ; oboInOwl:hasDbXref "EHDAA2:0001846", "EHDAA:6538", "FMA:295662", "NCIT:C34247", "TAO:0001185", "UMLS:C1518973", "VHOG:0001680", "XAO:0000029", "ZFA:0001185" ; oboInOwl:hasExactSynonym "skin periderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "EVL", "epidermis epithelial layer", "epidermis outer layer", "epitrichium", "periderm" ; oboInOwl:id "UBERON:0003055" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "periderm" ; rdfs:subClassOf obo:UBERON_0000487, _:genid126292, _:genid126294, _:genid126296 . obo:UBERON_0003056 obo:IAO_0000115 "The portion of neural plate anterior to the mid-hindbrain junction." ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011084", "TAO:0007016", "VHOG:0001200", "XAO:0000045", "ZFA:0007016" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior neural plate" ; oboInOwl:id "UBERON:0003056" ; a owl:Class ; rdfs:label "pre-chordal neural plate" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003075 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0009615 ] . obo:UBERON_0003057 obo:IAO_0000115 "The portion of neural plate posterior to the mid-hindbrain junction." ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasDbXref "TAO:0007017", "VHOG:0001201", "XAO:0000046", "ZFA:0007017" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior neural plate" ; oboInOwl:id "UBERON:0003057" ; a owl:Class ; rdfs:label "chordal neural plate" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003075 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000099 ; owl:someValuesFrom obo:UBERON_0009615 ] . obo:UBERON_0003059 obo:IAO_0000115 "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." ; obo:UBPROP_0000001 "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011086", "EFO:0001982", "EMAPA:16189", "EMAPA:16752", "TAO:0000279", "VHOG:0000559", "XAO:0000057", "ZFA:0000279" ; oboInOwl:hasExactSynonym "segmental plate", "unsegmented paraxial mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PSM", "presumptive somite mesoderm", "somitogenic mesoderm", "somitomeric mesoderm", "unsegmented mesenchyme" ; oboInOwl:id "UBERON:0003059" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "presomitic mesoderm" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003077 ], _:genid126320 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 _:genid125325 [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007282 ] ) ] . obo:UBERON_0003060 obo:IAO_0000115 "In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]." ; obo:UBPROP_0000001 "Duct of the embryonic kidney, present bilaterally ventral to the somites and leading to the anal region where it empties separately from, and just posterior to the anus. Kimmel et al, 1995.[TAO]", "The first-formed kidney duct, which drains the kidney of most anamniotes and becomes the ductus deferens of male amniotes. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-3, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "(...) in all craniates, the archinephric duct develops in embryogeny.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011088", "NCIT:C34279", "SCTID:361406002", "TAO:0000150", "UMLS:C1283945", "VHOG:0000082", "Wikipedia:Pronephric_duct", "XAO:0000063", "ZFA:0000150" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "archinephric duct", "ductus pronephricus", "pronephric ducts" ; oboInOwl:id "UBERON:0003060" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:comment "The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney[GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]" ; rdfs:label "pronephric duct" ; rdfs:subClassOf obo:UBERON_0009201, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ], _:genid126330, _:genid126332 . obo:UBERON_0003061 obo:IAO_0000115 "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." ; obo:UBPROP_0000001 "Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO]", "Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO]" ; obo:UBPROP_0000003 "Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac" ; oboInOwl:hasBroadSynonym "ventral lateral plate mesoderm" ; oboInOwl:hasDbXref "AAO:0011006", "EFO:0003489", "EHDAA:207", "NCIT:C34113", "TAO:0000094", "TE:E5.11.2.0.0.0.4", "UMLS:C1511224", "VHOG:0000085", "Wikipedia:Blood_island_of_umbilical_vesicle", "XAO:0000067", "ZFA:0000094" ; oboInOwl:hasExactSynonym "blood islands" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "VBI", "caudal hematopoietic tissue", "posterior ICM", "posterior blood island", "ventral blood island" ; oboInOwl:id "UBERON:0003061" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "blood island" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002390 ] . obo:UBERON_0003063 obo:IAO_0000115 "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." ; obo:IAO_0000116 "TODO - check; developmental relationship to anterior hypoblast in ZFA?" ; obo:UBPROP_0000001 "Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO]", "Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG]" ; obo:UBPROP_0000003 "There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0004881" ; oboInOwl:hasBroadSynonym "head mesenchyme", "head mesoderm" ; oboInOwl:hasDbXref "AAO:0011085", "EHDAA2:0001493", "EHDAA:181", "FMA:295532", "TAO:0000060", "VHOG:0000086", "Wikipedia:Prechordal_plate", "XAO:0000079", "ZFA:0000060" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003063" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "prechordal plate" ; rdfs:subClassOf obo:UBERON_0005423, _:genid126353, _:genid126355 . obo:UBERON_0003064 obo:IAO_0000115 "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." ; obo:UBPROP_0000001 "Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO]" ; obo:UBPROP_0000003 "(...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG]" ; obo:UBPROP_0000012 "all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm')." ; oboInOwl:hasDbXref "AAO:0010575", "EMAPA:16056", "EMAPA:16178", "FMA:293147", "NCIT:C34193", "SCTID:361476001", "TAO:0001206", "UMLS:C1284010", "VHOG:0000087", "Wikipedia:Intermediate_mesoderm", "XAO:0000085", "ZFA:0001206" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "IM", "intermediate mesenchyme", "intermediate plate", "intermediate plate mesoderm", "mesenchyma intermedium" ; oboInOwl:id "UBERON:0003064" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intermediate mesoderm" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003077 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003081 ], _:genid126364, _:genid126366, _:genid126368 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0003066 obo:IAO_0000115 "The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements." ; obo:UBPROP_0000001 "The second of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000012 "in XAO, develops from visceral pouch 2" ; obo:UBPROP_0000103 "2"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010363", "EHDAA2:0000050", "EHDAA:611", "EMAPA:16272", "FMA:293017", "NCIT:C34288", "SCTID:308768003", "TAO:0001596", "VHOG:0000297", "Wikipedia:Second_pharyngeal_arch", "XAO:0000098", "ZFA:0001611" ; oboInOwl:hasExactSynonym "2nd pharyngeal arch", "arcus pharyngeus secundus", "branchial arch 2", "hyoid arch", "pharyngeal arch 2", "second branchial arch", "second pharyngeal arch", "second visceral arch", "visceral arch 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd arch", "2nd visceral arch", "hyoid bars", "pharyngeal arches 2" ; oboInOwl:id "UBERON:0003066" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch 2" ; rdfs:subClassOf obo:UBERON_0002539 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png"^^xsd:anyURI . obo:UBERON_0003067 obo:IAO_0000115 "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." ; obo:UBPROP_0000003 "In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" ; oboInOwl:hasDbXref "TAO:0001310", "VHOG:0000103", "XAO:0000187", "ZFA:0001310" ; oboInOwl:hasExactSynonym "dorsolateral placodes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003067" ; a owl:Class ; rdfs:comment "The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode" ; rdfs:label "dorsolateral placode" ; rdfs:subClassOf obo:UBERON_0009955, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0003078 ] . obo:UBERON_0003068 obo:IAO_0000115 "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." ; obo:UBPROP_0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" ; oboInOwl:hasDbXref "AAO:0011017", "EFO:0003647", "TAO:0001204", "VHOG:0000107", "Wikipedia:Chordamesoderm", "XAO:0000205", "ZFA:0001204" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chordamesoderm" ; oboInOwl:id "UBERON:0003068" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "axial mesoderm" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0003069 obo:IAO_0000115 "A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK]." ; obo:UBPROP_0000001 "Primordium of the ear epithelium before it hollows into the otic vesicle, present beside the hindbrain rudiment in the midsegmentation period. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG]" ; obo:UBPROP_0000011 "With the exception of the pigment cells of the stria vascularis and the secretory epithelium of the cochlea, which are of neural crest origin, all compo- nents of the inner ear derive from the otic placode. In most species the thickening of the ectoderm into a placode occurs in a region adjacent to rhombomere 5 (reviewed in Ohyama et al., 2007), while in amphibians the otic placode is centered onto rhombomere 4 (Ruiz i Altaba and Jessell, 1991)." ; oboInOwl:hasDbXref "AAO:0011079", "EFO:0003429", "EHDAA2:0001339", "EHDAA:506", "EMAPA:16195", "FMA:293973", "NCIT:C34239", "TAO:0000138", "UMLS:C1518677", "VHOG:0000235", "Wikipedia:Otic_placode", "XAO:0000223", "ZFA:0000138" ; oboInOwl:hasExactSynonym "placoda otica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory placode", "ear placode", "ear/otic placode", "octaval VIII placode", "octaval placode" ; oboInOwl:id "UBERON:0003069" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "otic placode" ; rdfs:subClassOf obo:UBERON_0003067, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ] . obo:UBERON_0003070 obo:IAO_0000115 "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." ; obo:UBPROP_0000001 "The ectodermal precursor of the trigeminal ganglion. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24.[XAO]", "The ectodermal rudiment of the trigeminal ganglion, distinguishable during much of the segmentation period. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "The dorsolateral placodes (trigeminal and vestibular) develop from ectoderm lateral to the brain (...). In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" ; obo:UBPROP_0000013 "Consider naming this 'trigeminal placode complex'. Also, Fig9-5 of ISBN:0471888893 calls this the profundus placode; XAO says 'profundal and the trigeminal ganglia are separate distally but fused at their proximal end...'" ; oboInOwl:hasDbXref "EFO:0003433", "EHDAA2:0004209", "TAO:0000162", "VHOG:0000109", "XAO:0000225", "ZFA:0000162" ; oboInOwl:hasExactSynonym "trigeminal V placode", "trigeminal placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "profundus V placode", "profundus placode", "trigeminal placodes" ; oboInOwl:id "UBERON:0003070" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "trigeminal placode complex" ; rdfs:subClassOf obo:UBERON_0003067, [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0003942 ] . obo:UBERON_0003071 obo:IAO_0000115 "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." ; obo:UBPROP_0000012 "TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium." ; oboInOwl:hasAlternativeId "UBERON:0005060" ; oboInOwl:hasDbXref "AAO:0011038", "EFO:0003541", "EHDAA2:0004431", "TAO:0000570", "XAO:0000227", "XAO:0004090", "ZFA:0000570" ; oboInOwl:hasExactSynonym "eye placode", "occular primordium", "ocular primordium", "optic placode", "optic placode of camera-type eye", "optic primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye anlage", "eye field", "optic field", "optic placodes" ; oboInOwl:id "UBERON:0003071" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "eye primordium" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003056 ], _:genid126430 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003072 obo:IAO_0000115 "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0005351", "EHDAA2:0001303", "EHDAA:2912", "EMAPA:16674", "NCIT:C34233", "SCTID:308789007", "TAO:0001202", "UMLS:C0231109", "VHOG:0000167", "ZFA:0001202" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye cup", "eyecup", "ocular cup", "ophtalmic cup" ; oboInOwl:id "UBERON:0003072" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "optic cup" ; rdfs:subClassOf obo:UBERON_0000481, _:genid125441, _:genid126440, _:genid126442 . obo:UBERON_0003073 obo:IAO_0000115 "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." ; obo:UBPROP_0000001 "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" ; obo:UBPROP_0000011 "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" ; oboInOwl:hasDbXref "AAO:0011055", "EFO:0003494", "EHDAA2:0000982", "EHDAA:2908", "EMAPA:16672", "FMA:296767", "NCIT:C34202", "TAO:0000122", "UMLS:C1517770", "VHOG:0000166", "Wikipedia:Lens_placode", "XAO:0000240", "ZFA:0000122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lens placodes", "placoda lentis" ; oboInOwl:id "UBERON:0003073" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lens placode" ; rdfs:subClassOf obo:UBERON_0002546, obo:UBERON_0011814, [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0004128 ], _:genid126456 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000965 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png"^^xsd:anyURI . obo:UBERON_0003074 obo:IAO_0000115 "Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]." ; obo:IAO_0000116 "Consider adding subclasses for male and female specific variants", "TODO - mesonephric portion of the nephric duct" ; obo:UBPROP_0000001 "Anatomical structure consisting of either of a pair of longitudinal ducts which carry urine and in males, sperm, to the cloaca.[AAO]", "The first-formed kidney duct, which drains the kidney of most anamniotes and becomes the ductus deferens of male amniotes. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-3, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "(...) in all craniates, the archinephric duct develops in embryogeny.[well established][VHOG]" ; obo:UBPROP_0000011 "In the male the Wolffian duct persists, and forms for example the epididymis, the ductus deferens, the ejaculatory duct, seminal vesicle and efferent ducts." ; oboInOwl:hasDbXref "AAO:0000637", "EHDAA2:0001243", "EHDAA:1590", "EMAPA:16577", "GAID:1315", "MESH:D014928", "NCIT:C26469", "SCTID:308800003", "TAO:0000546", "UMLS:C0043204", "VHOG:0000082", "Wikipedia:Mesonephric_duct", "XAO:0000242", "ZFA:0000546" ; oboInOwl:hasExactSynonym "Wolffian duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Leydig's duct", "archinephric duct", "ductus mesonephricus; ductus Wolffi", "renal duct" ; oboInOwl:id "UBERON:0003074" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesonephric duct" ; rdfs:subClassOf obo:UBERON_0009201, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003060 ], _:genid126469 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png"^^xsd:anyURI . obo:UBERON_0003075 obo:IAO_0000115 "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." ; obo:UBPROP_0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011072", "BTO:0001765", "DHBA:10153", "DMBA:15565", "EHDAA:346", "EHDAA:902", "EMAPA:35593", "FMA:293879", "MESH:D054258", "NCIT:C34225", "RETIRED_EHDAA2:0001252", "TAO:0000132", "UMLS:C0920623", "VHOG:0000068", "Wikipedia:Neural_plate", "XAO:0000249", "ZFA:0000132", "neuronames:1362" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lamina neuralis", "presumptive central nervous system" ; oboInOwl:id "UBERON:0003075" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neural plate" ; rdfs:subClassOf obo:UBERON_0000483, obo:UBERON_0016879, _:genid126481, _:genid126483 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png"^^xsd:anyURI . obo:UBERON_0003076 obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011082", "TAO:0007037", "VHOG:0001383", "XAO:0000250", "ZFA:0007037" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003076" ; a owl:Class ; rdfs:label "posterior neural tube" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003057 ] ; owl:disjointWith obo:UBERON_0003080 . obo:UBERON_0003077 obo:IAO_0000115 "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." ; obo:UBPROP_0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" ; obo:UBPROP_0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" ; obo:UBPROP_0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" ; oboInOwl:hasDbXref "AAO:0010568", "EFO:0003515", "EMAPA:16183", "EMAPA:16751", "FMA:293145", "NCIT:C34244", "SCTID:361475002", "TAO:0000255", "UMLS:C1284009", "VHOG:0000114", "Wikipedia:Paraxial_mesoderm", "XAO:0000259", "ZFA:0000255" ; oboInOwl:hasExactSynonym "paraxial mesenchyme", "somitic mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesoderma paraxiale" ; oboInOwl:id "UBERON:0003077" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "paraxial mesoderm" ; rdfs:subClassOf obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid125490, [ a owl:Restriction ; owl:onProperty obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000109 ], _:genid126498 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0003078 obo:IAO_0000115 "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." ; obo:UBPROP_0000001 "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. [Graham_A, The_development_and_evolution_of_the_pharyngeal_arches._J_Anat_(2001)_199:_133-141][VHOG]" ; obo:UBPROP_0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" ; obo:UBPROP_0000011 "Epibranchial placodes-derived neurons innervate internal organs to transmit information such as heart rate, blood pressure, and visceral distension from the periphery to the central nervous system (Baker and Bronner-Fraser, 2001). From rostral to caudal the epibranchial placodes comprise the geniculate, petrosal, and nodose placodes, each associated in sequence with the first, second and third branchial clefts. Each placode contributes sensory neurons to cranial nerves VII (facial nerve), IX (glossopharyngeal nerve), and X (vagal nerve), respectively" ; obo:UBPROP_0000012 "in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group" ; oboInOwl:hasDbXref "AAO:0011036", "EFO:0003455", "FMA:293968", "TAO:0001294", "VHOG:0000117", "XAO:0000284", "ZFA:0001294" ; oboInOwl:hasExactSynonym "epibranchial placodes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventrolateral placode" ; oboInOwl:id "UBERON:0003078" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "epibranchial placode" ; rdfs:subClassOf obo:UBERON_0009955, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0002410 ], _:genid126509, _:genid126512 . obo:UBERON_0003080 obo:IAO_0000116 "TODO - add grouping class for the anterior end of the neural tube at all stages" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011012", "TAO:0007038", "VHOG:0001384", "XAO:0000307", "ZFA:0007038" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003080" ; a owl:Class ; rdfs:label "anterior neural tube" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003056 ] . obo:UBERON_0003081 obo:IAO_0000115 "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." ; obo:UBPROP_0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]", "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" ; obo:UBPROP_0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" ; obo:UBPROP_0000012 "subclass of mesoderm in ZFA." ; oboInOwl:hasAlternativeId "UBERON:0006258" ; oboInOwl:hasDbXref "AAO:0010574", "EHDAA2:0000919", "EHDAA:379", "EMAPA:16179", "FMA:293149", "NCIT:C34199", "SCTID:361477005", "TAO:0000121", "UMLS:C1517749", "VHOG:0000118", "Wikipedia:Lateral_plate_mesoderm", "XAO:0000311", "ZFA:0000121" ; oboInOwl:hasExactSynonym "LPM", "lateral mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral plate", "lateral plate mesenchyme", "mesoderma laminae lateralis" ; oboInOwl:id "UBERON:0003081" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "lateral plate mesoderm" ; rdfs:subClassOf obo:UBERON_0005423, obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0003887 ], _:genid126527, _:genid126529 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png"^^xsd:anyURI . obo:UBERON_0003082 obo:IAO_0000115 "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." ; obo:IAO_0000116 "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." ; obo:UBPROP_0000001 "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000003 "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011067", "AEO:0001018", "BTO:0000742", "EHDAA2_RETIRED:0003431", "EHDAA:1721", "EHDAA:1727", "EHDAA:1733", "EHDAA:1739", "EMAPA:32841", "FMA:295658", "NCIT:C34214", "SCTID:344535001", "TAO:0001056", "UMLS:C1513802", "VHOG:0001244", "Wikipedia:Myotome", "XAO:0000315", "ZFA:0001056" ; oboInOwl:hasExactSynonym "myomeres" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle plate", "myomere", "myotome region", "myotomes", "myotomus" ; oboInOwl:id "UBERON:0003082" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "myotome" ; rdfs:subClassOf obo:UBERON_0017650, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001630 ], _:genid126543, _:genid126545 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png"^^xsd:anyURI . obo:UBERON_0003083 obo:IAO_0000115 "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." ; obo:UBPROP_0000001 "Post-cranial portion of the neural crest. Exact anatomical derivations not experimentally resolved in amphibians.[AAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010582", "EFO:0003605", "EHDAA2:0001901", "TAO:0001024", "VHOG:0000062", "Wikipedia:Trunk_neural_crest", "XAO:0000319", "ZFA:0001024" ; oboInOwl:hasExactSynonym "TNC" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trunk crest" ; oboInOwl:id "UBERON:0003083" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "trunk neural crest" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ], _:genid126555 . obo:UBERON_0003084 obo:IAO_0000115 "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." ; obo:IAO_0000116 "should probably be merged with heart rudiment." ; obo:UBPROP_0000001 "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]", "The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO]" ; oboInOwl:hasDbXref "AAO:0011044", "BTO:0001887", "NCIT:C34276", "TAO:0000028", "UMLS:C1514450", "XAO:0000336", "ZFA:0000028" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac field", "fused heart primordium" ; oboInOwl:id "UBERON:0003084" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "heart primordium" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004140 ], _:genid126562, _:genid126564, _:genid126567 . obo:UBERON_0003086 obo:IAO_0000115 "Extension of the dorsal aorta in the tail." ; obo:UBPROP_0000001 "Extension of the dorsal aorta in the tail. Kimmel et al, 1995.[TAO]", "The posterior extension of the dorsal aorta to the tail region, which degenerates at metamorphosis.[AAO]" ; oboInOwl:hasDbXref "AAO:0011023", "EFO:0003472", "TAO:0000011", "VHOG:0000123", "Wikipedia:Caudal_artery", "XAO:0000364", "ZFA:0000011" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CA" ; oboInOwl:id "UBERON:0003086" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim ; a owl:Class ; rdfs:label "caudal artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001073 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0005805 ] ) ] . obo:UBERON_0003089 obo:IAO_0000115 "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." ; obo:UBPROP_0000001 "Skeletogenic portion of somites.[AAO]" ; obo:UBPROP_0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" ; obo:UBPROP_0000012 "part_of somite in XAO" ; oboInOwl:hasDbXref "AAO:0010571", "AEO:0000212", "EHDAA2:0003439", "EMAPA:31159", "FMA:295652", "NCIT:C34287", "TAO:0001080", "UMLS:C0183176", "VHOG:0000680", "Wikipedia:Sclerotome", "XAO:0000397", "ZFA:0001080" ; oboInOwl:hasExactSynonym "sclerotomes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sclerotomus" ; oboInOwl:id "UBERON:0003089" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "sclerotome" ; rdfs:subClassOf obo:UBERON_0005856, obo:UBERON_0007530, _:genid126587 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png"^^xsd:anyURI . obo:UBERON_0003091 obo:IAO_0000115 "The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." ; obo:UBPROP_0000001 "Portion of tissue part of the pharyngeal endoderm that is fated to become thyroid follicle[ZFIN:curator]." ; obo:UBPROP_0000008 "In all vertebrates the thyroid arises from the ventral aspect of the second pouch" ; obo:UBPROP_0000012 "Note that we follow EHDAA2 in dividing this into endoderm and mesenchyme. In this ontology we place the broad developmental relationship at this level, and include specific relationships to the pharyngeal endoderm at the level of the endoderm" ; oboInOwl:hasDbXref "AAO:0011106", "BTO:0004709", "EHDAA2:0002033", "EHDAA:952", "EMAPA:16361", "NCIT:C34312", "TAO:0001081", "UMLS:C1519512", "XAO:0000444", "ZFA:0001081" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thyroid primordia" ; oboInOwl:id "UBERON:0003091" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "thyroid primordium" ; rdfs:subClassOf obo:UBERON_0000479, obo:UBERON_0001048, _:genid126597, _:genid126599, _:genid126601 . obo:UBERON_0003098 obo:IAO_0000115 "The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain." ; obo:UBPROP_0000001 "The evagination from the neural tube of the developing embryo which develops the optic cup at its extremity; the stalk persists as the optic nerve. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011077", "EHDAA2:0001318", "EHDAA:3816", "EMAPA:16678", "NCIT:C34235", "SCTID:308788004", "TAO:0000137", "UMLS:C0231107", "VHOG:0000223", "Wikipedia:Optic_stalk", "XAO:0000475", "ZFA:0000137" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "optic stalks", "pedunculus opticus" ; oboInOwl:id "UBERON:0003098" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "optic stalk" ; rdfs:subClassOf obo:UBERON_0034705, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003072 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png"^^xsd:anyURI . obo:UBERON_0003099 obo:IAO_0000115 "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." ; obo:UBPROP_0000001 "Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO]", "Neural crest that is part of the head.[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010580", "EFO:0003645", "EHDAA2:0004420", "EMAPA:16091", "TAO:0001194", "VHOG:0000063", "Wikipedia:Cranial_neural_crest", "XAO:0001001", "ZFA:0001194" ; oboInOwl:hasExactSynonym "CNC", "cephalic neural crest", "cranial NCC population", "head NCC population" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crista neuralis cranialis", "head crest", "head neural crest" ; oboInOwl:id "UBERON:0003099" ; oboInOwl:inSubset core:efo_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cranial neural crest" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000008 ] . obo:UBERON_0003100 obo:IAO_0000115 "Gonochoristic organism that can produce female gametes." ; obo:RO_0002171 obo:UBERON_0003101 ; oboInOwl:hasDbXref "AAO:0010030", "BILA:0000028", "CARO:0000028", "FBbt:00007011", "FMA:67812", "HAO:0000028", "SCTID:362608006", "TAO:0000303", "TGMA:0001839", "XAO:0003005", "ZFA:0000303" ; oboInOwl:hasNarrowSynonym "female human body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "female" ; oboInOwl:id "UBERON:0003100" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "female organism" ; rdfs:subClassOf obo:UBERON_0000468 ; owl:disjointWith obo:UBERON_0003101 . obo:UBERON_0003101 obo:IAO_0000115 "Gonochoristic organism that can produce male gametes." ; oboInOwl:hasDbXref "AAO:0010033", "BILA:0000027", "CARO:0000027", "FBbt:00007004", "FMA:67811", "HAO:0000027", "SCTID:362609003", "TAO:0000242", "TGMA:0001838", "WBbt:0007850", "XAO:0003006", "ZFA:0000242" ; oboInOwl:hasNarrowSynonym "male human body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male" ; oboInOwl:id "UBERON:0003101" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "male organism" ; rdfs:subClassOf obo:UBERON_0000468 . obo:UBERON_0003102 obo:IAO_0000115 "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." ; obo:IAO_0000116 "consider obsoleting. See issue/1305" ; obo:UBPROP_0000001 "Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA]" ; oboInOwl:hasDbXref "AAO:0010337", "AEO_RETIRED:0000010", "EHDAA2_RETIRED:0003010", "TAO:0000292", "VSAO:0000001", "Wikipedia:Surface_structure", "XAO:0003028", "ZFA:0000292", "galen:SurfaceRegion" ; oboInOwl:hasExactSynonym "anatomical surface feature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "surface feature", "surface region", "surface structures" ; oboInOwl:id "UBERON:0003102" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "surface structure" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013514 ] . obo:UBERON_0003103 obo:IAO_0000115 "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." ; obo:IAO_0000232 "this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs" ; oboInOwl:hasDbXref "AAO:0010015", "AEO:0000024", "BILA:0000024", "CARO:0000024", "EHDAA2:0003024", "HAO:0000024", "TADS:0000598", "TAO:0000496", "TGMA:0001837", "VHOG:0001723", "XAO:0003041", "ZFA:0000496" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organ" ; oboInOwl:id "UBERON:0003103" ; oboInOwl:inSubset core:organ_slim, core:upper_level ; a owl:Class ; rdfs:label "compound organ" ; rdfs:subClassOf obo:UBERON_0000062 . obo:UBERON_0003104 obo:IAO_0000115 "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." ; obo:IAO_0000116 "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" ; obo:UBPROP_0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]", "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" ; obo:UBPROP_0000007 "mesenchymal" ; oboInOwl:hasDbXref "AAO:0010427", "AEO:0000145", "BTO:0001393", "CALOHA:TS-0620", "EHDAA2:0003145", "EV:0100007", "NCIT:C13301", "TAO:0000393", "UMLS:C0162415", "VHOG:0000170", "Wikipedia:Mesenchyme", "XAO:0003046", "ZFA:0000393" ; oboInOwl:hasExactSynonym "mesenchymal tissue", "mesenchyme tissue", "portion of mesenchymal tissue", "portion of mesenchyme tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesenchyma" ; oboInOwl:id "UBERON:0003104" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002328 ; owl:someValuesFrom obo:GO_0032502 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid125620 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg"^^xsd:anyURI . obo:UBERON_0003107 obo:IAO_0000115 "Meckel's cartilage is the bilaterally paired, rod-like, cartilaginous ventral component of the lower jar, or ventral mandibular arch. It is typically resorbed in adults." ; obo:UBPROP_0000001 "Paired, rod-shaped elements that extend the length of the mandible and lie between the dentaries and the angulosplenials. Can be reduced to various extent in adults.[AAO]", "Pharyngeal arch cartilage that is the cartilaginous embryonic component of the lower jaw, or ventral mandibular arch. It develops into the endochondral articular and retroarticular bones. Meckel's cartilage is paired.[TAO]" ; obo:UBPROP_0000003 "In all jawed vertebrates, including fish, the first pharyngeal arch generates the jaw apparatus. The neural crest cells of this arch migrate to form Meckel's cartilage, the precursor of the jaw.[well established][VHOG]" ; obo:UBPROP_0000008 "functional lower jaw of Elasmobranchii and Holocephali, the embryonic lower jaw of other gnathostomous vertebrates" ; oboInOwl:hasDbXref "AAO:0000289", "EHDAA2:0001072", "EHDAA:7997", "EMAPA:17635", "FMA:295784", "MA:0001580", "SCTID:308773009", "TAO:0001205", "VHOG:0000249", "Wikipedia:Meckel's_cartilage", "XAO:0003085", "ZFA:0001205" ; oboInOwl:hasExactSynonym "Meckels cartilage", "cartilago arcus pharyngei primi", "primary mandinle", "ventral mandibular cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003107" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "Meckel's cartilage" ; rdfs:subClassOf obo:UBERON_0011004, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006263 ], _:genid126650, _:genid126652 . obo:UBERON_0003110 obo:UBPROP_0000001 "Anatomical cluster that is a posterolateral part of the cranium and structurally supports the vestibuloauditory system.[TAO]", "Anatomical cluster that is a posterolateral part of the neurocranium and structurally supports the vestibuloauditory system.[AAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]" ; obo:UBPROP_0000012 "UBERONREF:0000007 has this as a syn for otic capsule" ; oboInOwl:hasDbXref "AAO:0010208", "TAO:0000189", "XAO:0003175", "ZFA:0000189" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial vault" ; oboInOwl:id "UBERON:0003110" ; a owl:Class ; rdfs:label "otic region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 ] . obo:UBERON_0003111 obo:IAO_0000115 "Anatomical cluster that forms the floor and sidewalls of the middle part of the cranium." ; obo:UBPROP_0000001 "Anatomical cluster that forms the floor and sidewalls of the middle part of the neurocranium.[AAO]" ; oboInOwl:hasDbXref "AAO:0010207", "TAO:0000290", "XAO:0003174", "ZFA:0000290" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003111" ; a owl:Class ; rdfs:label "sphenoid region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 ] . obo:UBERON_0003112 obo:IAO_0000115 "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." ; obo:UBPROP_0000001 "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the peripheral olfactory organ.[TAO]", "Anatomical cluster that is located in the anterior region of the neurocranium and provides structural support for the olfactory organs.[AAO]" ; oboInOwl:hasDbXref "AAO:0010206", "EFO:0003525", "NCIT:C98765", "TAO:0000351", "XAO:0003172", "ZFA:0000351" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ethmoid region" ; oboInOwl:id "UBERON:0003112" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "olfactory region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 ] . obo:UBERON_0003113 obo:IAO_0000115 "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." ; obo:IAO_0000116 "wikipedia treats skull roof and dermatocranium as synonymous, but some sources treat the roof as being part of the dermatocranium - see UBERONREF:0000007" ; obo:UBPROP_0000001 "Anatomical cluster that is part of the cranium and composed of dermally derived bones.[TAO]", "Anatomical cluster that is part of the cranium which consists of dermally derived bones.[AAO]" ; oboInOwl:hasDbXref "AAO:0010154", "TAO:0000863", "VHOG:0001665", "Wikipedia:Skull_roof", "XAO:0003169", "ZFA:0000863" ; oboInOwl:hasExactSynonym "dendrocranium", "exocranium" ; oboInOwl:hasNarrowSynonym "dermal skull roof", "dermatocranial cover", "roof of skull", "skull roof" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermal bone cranium", "dermal part of skull", "dermal skull bones", "roofing bones of the skull", "skull exoskeleton" ; oboInOwl:id "UBERON:0003113" ; a owl:Class ; rdfs:label "dermatocranium" ; rdfs:subClassOf obo:UBERON_0011159, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010364 ], _:genid126679 . obo:UBERON_0003114 obo:IAO_0000115 "The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus." ; obo:UBPROP_0000001 "The most anterior, or first, pharygeal/branchial arch, composed of the mandibular process, forming the posterior border of the stomodeum, and the maxillary process anterior to the stomodeum, contains the first aortic arch.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000012 "in XAO, called branchial arch 1 and df VP3" ; obo:UBPROP_0000103 "3"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010365", "EHDAA2:0000069", "EHDAA:1080", "EMAPA:16399", "FMA:293029", "SCTID:308769006", "TAO:0001598", "VHOG:0000298", "XAO:0000447", "ZFA:0001606" ; oboInOwl:hasExactSynonym "3rd pharyngeal arch", "first gill arch", "gill arch 1", "third pharyngeal arch", "third visceral arch", "visceral arch 3" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd arch", "3rd visceral arch", "branchial arch 1", "first branchial arch" ; oboInOwl:id "UBERON:0003114" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch 3" ; rdfs:subClassOf obo:UBERON_0002539 . obo:UBERON_0003115 obo:IAO_0000115 "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." ; obo:UBPROP_0000001 "The second pharyngeal/branchial arch; arises as a thickening of the pharygeal wall between the first and second branchial clefts; contains the second aortic arch; forms part of the hyoid bone, tongue and facial musculature.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000012 "in XAO, called branchial arch 2 and df VP4" ; obo:UBPROP_0000103 "4"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010366", "EHDAA2:0000086", "EHDAA:1663", "EMAPA:16760", "FMA:293035", "SCTID:308770007", "TAO:0001599", "VHOG:0000299", "XAO:0000449", "ZFA:0001607" ; oboInOwl:hasExactSynonym "4th branchial arch", "4th pharyngeal arch", "4th visceral arch", "fourth pharyngeal arch", "gill arch 2", "second gill arch", "visceral arch 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "4th arch", "branchial arch 2", "fourth visceral arch", "second branchial arch" ; oboInOwl:id "UBERON:0003115" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch 4" ; rdfs:subClassOf obo:UBERON_0002539 . obo:UBERON_0003117 obo:IAO_0000115 "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." ; obo:UBPROP_0000001 "The forth in a series of paired bars in the wall of the pharynx, within which are formed the forth aortic arch and the cartilage bar of the visceral skeleton, forms and supports the gills.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000103 "6"^^xsd:nonNegativeInteger ; oboInOwl:hasAlternativeId "UBERON:0004349" ; oboInOwl:hasDbXref "AAO:0010368", "EHDAA2:0004075", "EMAPA:32766", "FMA:293047", "SCTID:308772004", "TAO:0001601", "VHOG:0001205", "XAO:0000453", "ZFA:0001609" ; oboInOwl:hasExactSynonym "6th arch", "gill arch 4", "sixth branchial arch", "visceral arch 6" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "6th pharyngeal arch", "6th visceral arch", "branchial arch 4", "fourth branchial arch", "sixth pharyngeal arch", "sixth visceral arch" ; oboInOwl:id "UBERON:0003117" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pharyngeal arch 6" ; rdfs:subClassOf obo:UBERON_0002539 . obo:UBERON_0003118 obo:IAO_0000115 "The vessels formed within the first pair of branchial arches in embryogenesis." ; obo:UBPROP_0000008 "Disappears early in development in tetrapods" ; obo:UBPROP_0000012 "ZFA states that The paired aortic arch 1 arteries branch off of the ventral aorta, and empty into the right and left lateral dorsal aortas" ; oboInOwl:hasAlternativeId "UBERON:0004371" ; oboInOwl:hasDbXref "AAO:0010415", "EHDAA2:0000007", "EMAPA:16202", "EMAPA:16685", "SCTID:308774003", "TAO:0005005", "VHOG:0000149", "XAO:0000342", "ZFA:0005005" ; oboInOwl:hasExactSynonym "1st arch artery", "AA1", "aortic arch 1", "first aortic arch", "first branchial arch artery", "mandibular aortic arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "1st aortic arch artery", "1st branchial arch artery", "1st pharyngeal arch artery", "first arch artery" ; oboInOwl:id "UBERON:0003118" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch artery 1" ; rdfs:subClassOf _:genid125706 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004362 ] ) ] . obo:UBERON_0003119 obo:IAO_0000115 "The vessels formed within the second pair of branchial arches in embryogenesis." ; obo:UBPROP_0000001 "The first and second arches disappear early, but the dorsal end of the second gives origin to the stapedial artery, a vessel which atrophies in humans but persists in some mammals. It passes through the ring of the stapes and divides into supraorbital, infraorbital, and mandibular branches which follow the three divisions of the trigeminal nerve. The infraorbital and mandibular arise from a common stem, the terminal part of which anastomoses with the external carotid. On the obliteration of the stapedial artery this anastomosis enlarges and forms the internal maxillary artery, and the branches of the stapedial artery are now branches of this vessel. The common stem of the infraorbital and mandibular branches passes between the two roots of the auriculotemporal nerve and becomes the middle meningeal artery; the original supraorbital branch of the stapedial is represented by the orbital twigs of the middle meningeal[WP][Wikipedia:Aortic_arches#Arches_1_and_2].", "The second in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 2 that is part of hyoid arch.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0004372" ; oboInOwl:hasDbXref "AAO:0010418", "EHDAA2:0000051", "EMAPA:16203", "EMAPA:16686", "SCTID:308775002", "TAO:0005006", "VHOG:0000148", "Wikipedia:Aortic_arches#Arches_1_and_2", "XAO:0000343", "ZFA:0005006" ; oboInOwl:hasExactSynonym "2nd arch artery", "AA2", "aortic arch 2", "hyoid aortic arch", "second aortic arch", "second branchial arch artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd aortic arch artery", "2nd branchial arch artery", "2nd pharyngeal arch artery" ; oboInOwl:id "UBERON:0003119" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch artery 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ] . obo:UBERON_0003120 obo:IAO_0000115 "The vessels formed within the third pair of branchial arches in embryogenesis." ; obo:UBPROP_0000001 "Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO]", "The third aortic arch constitutes the commencement of the internal carotid artery, and is therefore named the carotid arch[WP][Wikipedia:Aortic_arches#Arch_3].", "The third in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 3 lies within the 3rd branchial arch and branches directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0004352" ; oboInOwl:hasDbXref "AAO:0010419", "EHDAA2:0000070", "EMAPA:16687", "SCTID:308776001", "TAO:0005007", "VHOG:0000147", "Wikipedia:Aortic_arches#Arch_3", "XAO:0000344", "ZFA:0005007" ; oboInOwl:hasExactSynonym "3rd arch artery", "AA3", "aortic arch 3", "carotid arch", "third aortic arch", "third branchial arch artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd aortic arch artery", "3rd branchial arch artery", "3rd pharyngeal arch artery" ; oboInOwl:id "UBERON:0003120" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch artery 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003114 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0003121 obo:IAO_0000115 "The vessels formed within the fourth pair of branchial arches in embryogenesis." ; obo:UBPROP_0000001 "Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO]", "The forth in a series paired arterial connections between the dorsal and ventral aortae, lies within the 4th branchial arch. The paired aortic arch 4 arteries branch directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO]", "The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]." ; obo:UBPROP_0000011 "Normally, the left fourth arch becomes the aortic arch, the right fourth arch contributes to the innominate artery[http://emedicine.medscape.com/article/899609-overview] in birds it is the right fourth arch which forms the permanent aorta" ; oboInOwl:hasAlternativeId "UBERON:0004350" ; oboInOwl:hasDbXref "AAO:0010420", "EHDAA2:0000087", "EMAPA:17004", "SCTID:308777005", "TAO:0005008", "Wikipedia:Aortic_arches#Arch_4", "XAO:0000355", "ZFA:0005008" ; oboInOwl:hasExactSynonym "4th arch artery", "AA4", "aortic arch 4", "fourth aortic arch", "fourth branchial arch artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "4th aortic arch artery", "4th branchial arch artery", "4th pharyngeal arch artery", "systemic arch" ; oboInOwl:id "UBERON:0003121" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "proximal right subclavian" ; rdfs:label "pharyngeal arch artery 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0003123 obo:IAO_0000115 "The vessels formed within the sixth pair of branchial arches in embryogenesis." ; obo:UBPROP_0000001 "The fifth and sixth arches, which come on-line at approximately 2.5 dpf, have a common trunk from the ventral aorta and drain to the midline dorsal aorta via an independent route. The fifth and sixth aortic arches supply the trunk and tail with oxigenated blood. Isogai et al. 2001.[TAO]", "The sixth in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 6 artery is paired and has a common trunk with aortic arch 5 from the ventral aorta, and drains via a separate branch of the lateral dorsal aorta. It forms part of the pulmonary arteries, and in the later embryo, the ductus arteriosis. Aortic arches 5 and 6 together supply the trunk and tail with oxygenated blood.[AAO]", "The sixth right arch disappears; the sixth left arch gives off the pulmonary arteries and forms the ductus arteriosus; this duct remains pervious during the whole of fetal life, but then closes within the first few days after birth due to increased O2 concentration. Oxygen concentration causes the production of bradykinin which causes the ductus to constrict occluding all flow. Within 1-3 months, the ductus is obliterated and becomes the ligamentum arteriosus. His showed that in the early embryo the right and left arches each gives a branch to the lungs, but that later both pulmonary arteries take origin from the left arch[WP][Wikipedia:Aortic_arches#Arch_6]." ; obo:UBPROP_0000011 "the distal left sixth arch becomes the ductus arteriosus, the proximal sixth arches bilaterally contribute to the proximal branch pulmonary arteries" ; oboInOwl:hasAlternativeId "UBERON:0004351" ; oboInOwl:hasDbXref "AAO:0010422", "EHDAA2:0000102", "EMAPA:17005", "SCTID:308779008", "TAO:0005016", "VHOG:0000144", "Wikipedia:Aortic_arches#Arch_6", "XAO:0000353", "ZFA:0005016" ; oboInOwl:hasExactSynonym "6th arch artery", "AA6", "aortic arch 6", "sixth aortic arch", "sixth branchial arch artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "6th aortic arch artery", "6th branchial arch artery", "6th pharyngeal arch artery", "pulmonary arch" ; oboInOwl:id "UBERON:0003123" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch artery 6" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003117 ] ) ] . obo:UBERON_0003124 obo:IAO_0000115 "The outermost extraembryonic membrane of amniotes." ; obo:UBPROP_0000001 "The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG]", "The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252]." ; obo:UBPROP_0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" ; obo:UBPROP_0000007 "chorionic" ; obo:UBPROP_0000008 "The chorion of placentals is bilaminar as in reptiles and birds, but forms from the trophoblast and includes the ajdacent mesodermal layer [ISBN:0073040584]" ; obo:UBPROP_0000011 "Extra-embryonic ectoderm" ; oboInOwl:hasDbXref "BTO:0000252", "CALOHA:TS-0144", "EFO:0002780", "EHDAA2:0000245", "EHDAA:150", "EMAPA:16112", "EV:0100121", "FMA:80224", "GAID:1299", "MESH:D002823", "NCIT:C34122", "NCIT:C34124", "UMLS:C0008503", "UMLS:C1516505", "VHOG:0000200", "Wikipedia:Chorion" ; oboInOwl:hasExactSynonym "chorion", "chorion (vertebrates)", "embryonic chorion", "fetal chorion", "uterine chorion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chorion frondosum", "chorionic sac" ; oboInOwl:id "UBERON:0003124" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:comment "This term refers to the amniote structure. It is distinct from the concept of chorion in insects" ; rdfs:label "chorion membrane" ; rdfs:subClassOf obo:UBERON_0005631, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003265 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003374 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid126809 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png"^^xsd:anyURI . obo:UBERON_0003126 obo:IAO_0000115 "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." ; obo:UBPROP_0000001 "An elongated tube which carries air to and from the lungs.[AAO]", "The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" ; obo:UBPROP_0000003 "In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG]" ; obo:UBPROP_0000007 "tracheal" ; obo:UBPROP_0000008 "In birds, the trachea runs from the pharynx to the syrinx, from which the primary bronchi diverge. Swans have an unusually elongated trachea, part of which is coiled beneath the sternum; this may act as a resonator to amplify sound. In some birds, the cartilagenous rings are complete, and may even be ossified. In amphibians, the trachea is normally extremely short, and leads directly into the lungs, without clear primary bronchi. A longer trachea is, however found in some long-necked salamanders, and in caecilians. While there are irregular cartilagenous nodules on the amphibian trachea, these do not form the rings found in amniotes. The only vertebrate to have lungs, but no trachea, is Polypterus, in which the lungs arise directly from the pharynx.", "in mouse 15-18 C-rings, 15-20 in human." ; oboInOwl:hasDbXref "AAO:0010140", "BTO:0001388", "CALOHA:TS-1060", "EFO:0000935", "EHDAA2:0002066", "EHDAA:3078", "EMAPA:16853", "EV:0100040", "FMA:7394", "GAID:361", "MA:0000441", "MAT:0000137", "MESH:D014132", "MIAA:0000137", "NCIT:C12428", "SCTID:181213009", "UMLS:C0040578", "VHOG:0000371", "Wikipedia:Vertebrate_trachea", "XAO:0000118" ; oboInOwl:hasExactSynonym "cartilaginous trachea", "vertebrate trachea", "windpipe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tracheal tubule" ; oboInOwl:id "UBERON:0003126" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:major_organ, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "trachea" ; rdfs:subClassOf obo:UBERON_0000117, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ], _:genid126824 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg"^^xsd:anyURI . obo:UBERON_0003128 obo:IAO_0000115 "Upper portion of the skull that excludes the mandible (when present in the organism)." ; obo:RO_0002171 obo:UBERON_0003278 ; obo:UBPROP_0000007 "cranial" ; obo:UBPROP_0000012 "the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium" ; obo:UBPROP_0000013 "The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton" ; oboInOwl:hasDbXref "BTO:0001328", "EFO:0000831", "EHDAA:6029", "EMAPA:17680", "FMA:71325", "MA:0000316", "MAT:0000340", "MIAA:0000340", "SCTID:181889008", "VHOG:0000334", "Wikipedia:Cranium_(anatomy)" ; oboInOwl:hasExactSynonym "bones of cranium", "ossa cranii", "set of bones of cranium", "skull minus mandible", "upper part of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calvarium", "epicranial plate", "skeletal system of head" ; oboInOwl:id "UBERON:0003128" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cranium" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] . obo:UBERON_0003129 obo:IAO_0000115 "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." ; obo:UBPROP_0000012 "in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible.", "in many ontologies, the structure called the cranium is inclusive of the mandible/lower jaw skeleton" ; obo:UBPROP_0000013 "A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates" ; oboInOwl:hasDbXref "BTO:0001295", "CALOHA:TS-2344", "EHDAA2:0000325", "EMAPA:17680", "FMA:46565", "GAID:82", "MESH:D012886", "NCIT:C12789", "SCTID:110530005", "UMLS:C0037303", "Wikipedia:Skull", "WikipediaCategory:Skull", "galen:Skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial skeleton", "skeletal system of head" ; oboInOwl:id "UBERON:0003129" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "skull" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010323 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003128 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003278 ] . obo:UBERON_0003133 obo:IAO_0000115 "An organ involved in reproduction." ; obo:UBPROP_0000012 "GO uses genitalia for the singular organ" ; oboInOwl:hasDbXref "EMAPA:17381", "EMAPA:37731", "MA:0001752", "MESH:D005835", "NCIT:C25177", "SCTID:128181006", "TGMA:0000591", "UMLS:C0017420", "WBbt:0008422" ; oboInOwl:hasExactSynonym "genital organ", "reproductive system organ", "sex organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "genitalia" ; oboInOwl:id "UBERON:0003133" ; oboInOwl:inSubset core:functional_classification, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "reproductive organ" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0000003 ] ) ] . obo:UBERON_0003134 obo:IAO_0000115 "A female organ involved in reproduction." ; oboInOwl:hasDbXref "EMAPA:28540", "MA:0000544" ; oboInOwl:hasExactSynonym "female organism reproductive organ", "female organism reproductive structure", "female organism reproductive system organ", "female organism sex organ", "female reproductive gland/organ", "female reproductive system organ", "female sex organ", "reproductive organ of female organism", "reproductive structure of female organism", "reproductive system organ of female organism", "sex organ of female organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003134" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "female reproductive organ" ; rdfs:subClassOf obo:UBERON_0003133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ) ] . obo:UBERON_0003135 obo:IAO_0000115 "A male organ involved in reproduction." ; oboInOwl:hasDbXref "MA:0000545", "WBbt:0008423" ; oboInOwl:hasExactSynonym "male organism reproductive organ", "male organism reproductive structure", "male organism reproductive system organ", "male organism sex organ", "male reproductive gland/organ", "male reproductive system organ", "male sex organ", "reproductive organ of male organism", "reproductive structure of male organism", "reproductive system organ of male organism", "sex organ of male organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male genital" ; oboInOwl:id "UBERON:0003135" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "male reproductive organ" ; rdfs:subClassOf obo:UBERON_0003133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] . obo:UBERON_0003212 obo:IAO_0000115 "Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912)." ; oboInOwl:hasDbXref "FBbt:00005159", "FMA:77853" ; oboInOwl:hasExactSynonym "gustatory organ system organ", "gustatory system organ", "organ of gustatory organ system", "organ of gustatory system", "organ of taste system", "taste organ", "taste system organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003212" ; a owl:Class ; rdfs:label "gustatory organ" ; rdfs:subClassOf obo:UBERON_0000005, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0050912 ] ) ] . obo:UBERON_0003214 obo:IAO_0000115 "A sac-like structure that is found in the mature gland[GO]." ; oboInOwl:hasDbXref "EMAPA:36566", "FMA:73285", "MA:0002760" ; oboInOwl:hasExactSynonym "alveolus of lactiferous gland", "alveolus of lobe of breast", "alveolus of lobe of mammary gland", "alveolus of mammary gland", "lactiferous alveolus", "lactiferous gland alveolus", "lobe of breast alveolus", "lobe of mammary gland alveolus", "mammary alveolus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary alveoli" ; oboInOwl:id "UBERON:0003214" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mammary gland alveolus" ; rdfs:subClassOf obo:UBERON_0003215, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001912 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001912 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0003215 obo:IAO_0000115 "Organ part that has the form of a hollow cavity[WP]." ; obo:UBPROP_0000007 "alveolar" ; oboInOwl:hasDbXref "EFO:0002513", "EV:0100043", "FMA:82493", "NCIT:C12986", "UMLS:C0034051", "Wikipedia:Alveolus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003215" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "alveolus" ; rdfs:subClassOf obo:UBERON_0000064 . obo:UBERON_0003216 obo:IAO_0000115 "Anterior portion of the palate consisting of bone and mucous membranes [GO]. The hard palate is formed from bony processes of the maxilla, premaxilla and palatine bone [Kardong]." ; obo:UBPROP_0000012 "in FMA this is divided into bony parts and submucosa" ; oboInOwl:hasDbXref "EMAPA:18952", "FMA:55023", "GAID:221", "MA:0002477", "MAT:0000161", "MESH:D021362", "MIAA:0000161", "NCIT:C12230", "SCTID:245778002", "UMLS:C0226901", "Wikipedia:Hard_palate" ; oboInOwl:hasExactSynonym "hard palate", "palatum durum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003216" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "hard palate" ; rdfs:subClassOf obo:UBERON_0034921, _:genid126923 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/f6/Illu_mouth.jpg"^^xsd:anyURI . obo:UBERON_0003218 obo:IAO_0000115 "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003218" ; a owl:Class ; rdfs:label "ovary septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0003220 obo:IAO_0000115 "One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]." ; obo:UBPROP_0000001 "A mass of intermediate mesodermal cells around the distal end of the ureteric bud that gives rise to nephrons in the metanephric kidney. [TFD][VHOG]" ; obo:UBPROP_0000003 "When the ureteric buds emerge from the nephric duct, they enter the metanephrogenic mesenchyme. The ureteric buds induce this mesenchymal tissue to condense around them and differentiate into the nephrons of the mammalian kidney. As this mesenchyme differentiates, it tells the ureteric bud to branch and grow.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0004062", "EHDAA:4041", "EHDAA:5021", "EHDAA:5915", "EMAPA:17375", "SCTID:361529008", "VHOG:0000540", "Wikipedia:Metanephric_blastema" ; oboInOwl:hasExactSynonym "metanephric blastema", "metanephric mesoderm", "metanephrogenic mesenchyme", "metanephros associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003220" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 \"Developmental Biology\"]" ; rdfs:label "metanephric mesenchyme" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003074 ], _:genid126940 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0003221 obo:IAO_0000115 "Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits." ; obo:UBPROP_0000007 "phalangeal" ; obo:UBPROP_0000008 "In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three" ; oboInOwl:hasDbXref "CALOHA:TS-2211", "EMAPA:32614", "FMA:321661", "MA:0000304", "NCIT:C33317", "SCTID:290029003", "UMLS:C0222682", "VSAO:0000199", "Wikipedia:Phalanx_bones", "galen:Phalanx" ; oboInOwl:hasExactSynonym "digit long bone", "long bone of digit", "phalange", "phalanges", "phalanx bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003221" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "phalanx" ; rdfs:subClassOf obo:UBERON_0002495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102544 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010701 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003229 obo:IAO_0000115 "An epithelium that is part of a elbow [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000430", "EHDAA:4168", "EHDAA:6214", "EMAPA:17415", "VHOG:0001044" ; oboInOwl:hasExactSynonym "cubital region epithelial tissue", "cubital region epithelium", "elbow epithelial tissue", "elbow epithelium", "epithelial tissue of cubital region", "epithelial tissue of elbow", "epithelium of cubital region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003229" ; a owl:Class ; rdfs:label "epithelium of elbow" ; rdfs:subClassOf _:genid126966 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] . obo:UBERON_0003230 obo:IAO_0000115 "An epithelium that is part of a wrist [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000219", "EHDAA:5198" ; oboInOwl:hasExactSynonym "carpal region epithelial tissue", "carpal region epithelium", "epithelial tissue of carpal region", "epithelial tissue of wrist", "epithelium of wrist", "wrist epithelial tissue", "wrist epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003230" ; a owl:Class ; rdfs:label "epithelium of carpal region" ; rdfs:subClassOf obo:UBERON_0000490, _:genid126981 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] . obo:UBERON_0003231 obo:IAO_0000115 "An epithelium that is part of a hip [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000784", "EHDAA:5155", "EHDAA:6180", "EMAPA:17491", "VHOG:0000779" ; oboInOwl:hasExactSynonym "epithelial tissue of hip", "epithelial tissue of hip region", "epithelial tissue of regio coxae", "epithelium of hip region", "epithelium of regio coxae", "hip epithelial tissue", "hip epithelium", "hip region epithelial tissue", "hip region epithelium", "regio coxae epithelial tissue", "regio coxae epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003231" ; a owl:Class ; rdfs:label "epithelium of hip" ; rdfs:subClassOf _:genid126995 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] . obo:UBERON_0003232 obo:IAO_0000115 "An epithelium that is part of a knee [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000896", "EHDAA:5161", "EHDAA:6186", "EMAPA:17494", "VHOG:0000810" ; oboInOwl:hasExactSynonym "epithelial tissue of knee", "knee epithelial tissue", "knee epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003232" ; a owl:Class ; rdfs:label "epithelium of knee" ; rdfs:subClassOf _:genid127013 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] . obo:UBERON_0003233 obo:IAO_0000115 "An epithelium that is part of a shoulder [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001835", "EHDAA:4182", "EHDAA:6230", "EMAPA:17422", "VHOG:0000761" ; oboInOwl:hasExactSynonym "epithelial tissue of shoulder", "shoulder epithelial tissue", "shoulder epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003233" ; a owl:Class ; rdfs:label "epithelium of shoulder" ; rdfs:subClassOf _:genid127023 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0003235 obo:IAO_0000115 "An epithelium that is part of a upper jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002119", "EHDAA:8027", "EMAPA:17943", "EMAPA:18971" ; oboInOwl:hasExactSynonym "epithelial tissue of palatoquadrate arch", "epithelial tissue of upper jaw", "epithelium of palatoquadrate arch", "palatoquadrate arch epithelial tissue", "palatoquadrate arch epithelium", "upper jaw epithelial tissue", "upper jaw epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003235" ; a owl:Class ; rdfs:label "epithelium of upper jaw" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0003236 obo:IAO_0000115 "An epithelium that is part of a lower jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001019", "EHDAA:7999", "EMAPA:35516", "VHOG:0000802" ; oboInOwl:hasExactSynonym "epithelial tissue of lower jaw", "epithelial tissue of ventral mandibular arch", "epithelium of ventral mandibular arch", "lower jaw epithelial tissue", "lower jaw epithelium", "ventral mandibular arch epithelial tissue", "ventral mandibular arch epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003236" ; a owl:Class ; rdfs:label "epithelium of lower jaw" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003243 obo:IAO_0000115 "An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA:4722", "EMAPA:17600", "RETIRED_EHDAA2:0000264", "VHOG:0000640" ; oboInOwl:hasExactSynonym "Reissner's canal epithelial tissue", "Reissner's canal epithelium", "cochlear duct epithelial tissue", "cochlear duct epithelium", "cochlear duct of membranous labyrinth epithelial tissue", "cochlear duct of membranous labyrinth epithelium", "epithelial tissue of Reissner's canal", "epithelial tissue of cochlear duct", "epithelial tissue of cochlear duct of membranous labyrinth", "epithelium of Reissner's canal", "epithelium of cochlear duct of membranous labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003243" ; a owl:Class ; rdfs:label "epithelium of cochlear duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid126022 ] . obo:UBERON_0003244 obo:IAO_0000115 "The epithelial layer of the luminal surfaces of the mammary gland." ; oboInOwl:hasDbXref "BTO:0001430", "CALOHA:TS-0593", "EHDAA2:0001057", "EHDAA:6526", "EMAPA:17760", "FMA:74445", "MA:0000792", "NCIT:C12937", "UMLS:C0596882", "VHOG:0001088" ; oboInOwl:hasExactSynonym "epithelium of lactiferous gland", "lactiferous gland epithelium", "mammary epithelium", "mammary gland epithelial tissue", "mammary gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003244" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of mammary gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001911 ], _:genid127073 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0003247 obo:IAO_0000115 "An epithelium that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000554", "EHDAA:4174", "EHDAA:6220", "EMAPA:17418", "VHOG:0001096" ; oboInOwl:hasExactSynonym "forearm epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003247" ; a owl:Class ; rdfs:label "epithelium of forearm" ; rdfs:subClassOf _:genid127087 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0003248 obo:IAO_0000115 "An epithelium that is part of a footplate." ; oboInOwl:hasDbXref "EHDAA2:0000548", "EHDAA:5145", "EHDAA:6144", "EMAPA:32655" ; oboInOwl:hasExactSynonym "foot plate epithelium", "footplate epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003248" ; a owl:Class ; rdfs:label "epithelium of footplate" ; rdfs:subClassOf obo:UBERON_0000490, _:genid127095 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006871 ] ) ] . obo:UBERON_0003249 obo:IAO_0000115 "An epithelium that is part of a otic placode [Automatically generated definition]." ; obo:IAO_0000116 "check ZFA, placemeant, appears to refer to both adult structures and primordium" ; oboInOwl:hasDbXref "EHDAA2:0001341", "EHDAA:510", "EMAPA:16197", "VHOG:0000636", "ZFA:0007068" ; oboInOwl:hasExactSynonym "epithelial tissue of otic placode", "otic epithelium", "otic placode epithelial tissue", "otic placode epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003249" ; a owl:Class ; rdfs:label "epithelium of otic placode" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003069 ] ) ] . obo:UBERON_0003252 obo:IAO_0000115 "Subdivision of skeletal system that consists of all ribs in an organism connected to the sternum and the vertebrae. Some vertebrates have abdominal ribs (gastrialia), not connected to the vertebrate - these are not considered part of the rib case." ; obo:UBPROP_0000001 "Anatomical cluster that consists of more than one rib in an individual.[TAO]" ; oboInOwl:hasDbXref "FMA:7480", "SCTID:361741004", "Wikipedia:Human_rib_cage", "Wikipedia:Rib_cage", "galen:RibCage" ; oboInOwl:hasExactSynonym "cavea thoracis", "rib cage", "thoracic cage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavea thoracis" ; oboInOwl:id "UBERON:0003252" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "thoracic rib cage" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014477 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014478 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005944 ], _:genid127108 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/88/Gray112.png"^^xsd:anyURI . obo:UBERON_0003253 obo:IAO_0000115 "The neck of the rib is the flattened portion which extends lateralward from the head; it is about 2.5 cm. long, and is placed in front of the transverse process of the lower of the two vertebrC& with which the head articulates. Its anterior surface is flat and smooth, its posterior rough for the attachment of the ligament of the neck, and perforated by numerous foramina. Of its two borders the superior presents a rough crest (crista colli costE) for the attachment of the anterior costotransverse ligament; its inferior border is rounded. On the posterior surface at the junction of the neck and body, and nearer the lower than the upper border, is an eminencebthe tubercle; it consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrC& to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs." ; oboInOwl:hasDbXref "EMAPA:37826", "FMA:7576", "SCTID:263359009", "Wikipedia:Neck_of_rib" ; oboInOwl:hasExactSynonym "collum costae", "rib neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "collum costae" ; oboInOwl:id "UBERON:0003253" ; a owl:Class ; rdfs:label "neck of rib" ; rdfs:subClassOf _:genid127123 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002228 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray122.png"^^xsd:anyURI . obo:UBERON_0003254 obo:IAO_0000116 "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion." ; oboInOwl:hasAlternativeId "UBERON:0008359" ; oboInOwl:hasDbXref "BTO:0000897", "EHDAA2:0000117", "EHDAA:138", "EMAPA:16110", "VHOG:0000621" ; oboInOwl:hasExactSynonym "amnion ectoderm", "amnionic ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "amnion epithelium" ; oboInOwl:id "UBERON:0003254" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "amniotic ectoderm" ; rdfs:subClassOf obo:UBERON_0000478, obo:UBERON_0000490, _:genid127132, _:genid127134 . obo:UBERON_0003257 obo:IAO_0000115 "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." ; oboInOwl:hasDbXref "EHDAA2:0002215", "EHDAA:166", "EMAPA:16086", "VHOG:0000626" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003257" ; a owl:Class ; rdfs:label "yolk sac endoderm" ; rdfs:subClassOf obo:UBERON_0000478 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0001040 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0003258 obo:IAO_0000115 "An endoderm that is part of a foregut [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check" ; oboInOwl:hasDbXref "EHDAA2:0004568", "EHDAA:524" ; oboInOwl:hasExactSynonym "foregut endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003258" ; a owl:Class ; rdfs:label "endoderm of foregut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0003259 obo:IAO_0000115 "An endoderm that is part of a midgut [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check" ; oboInOwl:hasDbXref "EHDAA:987", "EMAPA:16257", "RETIRED_EHDAA2:0001194", "VHOG:0001080" ; oboInOwl:hasExactSynonym "midgut endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003259" ; a owl:Class ; rdfs:label "endoderm of midgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0003260 obo:IAO_0000115 "An endoderm that is part of a hindgut [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check" ; oboInOwl:hasDbXref "EHDAA:979", "RETIRED_EHDAA2:0000781" ; oboInOwl:hasExactSynonym "hindgut endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003260" ; a owl:Class ; rdfs:label "endoderm of hindgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 _:genid126126 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0003261 obo:IAO_0000115 "An endoderm that is part of a thyroid primordium." ; oboInOwl:hasAlternativeId "UBERON:0005235" ; oboInOwl:hasDbXref "EHDAA:956", "EMAPA:25357", "RETIRED_EHDAA2:0002035", "VHOG:0001089" ; oboInOwl:hasExactSynonym "endoderm of thyroid primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003261" ; a owl:Class ; rdfs:label "thyroid primordium endoderm" ; rdfs:subClassOf _:genid127175 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003091 ] ) ] . obo:UBERON_0003262 obo:IAO_0000115 "A mesenchyme that is part of a amnion." ; obo:IAO_0000116 "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion." ; oboInOwl:hasAlternativeId "UBERON:0003411" ; oboInOwl:hasDbXref "EHDAA2:0000118", "EHDAA:140", "EMAPA:16111", "EMAPA:16265", "VHOG:0000622" ; oboInOwl:hasExactSynonym "amnion mesenchyme", "amnion mesoderm", "amnionic mesoderm", "mesenchyme of amnion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "amnionic mesenchyme", "amnionic mesoderm" ; oboInOwl:id "UBERON:0003262" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "amniotic mesoderm" ; rdfs:subClassOf obo:UBERON_0000478, obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ], _:genid127186 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 ] ) ] . obo:UBERON_0003265 obo:IAO_0000115 "A mesenchyme that is part of a chorion." ; obo:IAO_0000116 "TODO - check" ; oboInOwl:hasAlternativeId "UBERON:0003423" ; oboInOwl:hasDbXref "EHDAA2:0003245", "EHDAA:154", "EMAPA:16114", "EMAPA:16266", "RETIRED_EHDAA2:0000247", "VHOG:0000620" ; oboInOwl:hasExactSynonym "chorion mesenchyme", "chorion mesoderm", "chorionic mesenchyme", "mesenchyme of chorion", "mesenchyme of chorion (vertebrates)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003265" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "chorionic mesenchyme" ; rdfs:subClassOf obo:UBERON_0000478, obo:UBERON_0007524, _:genid127201, _:genid127203 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] ) ] . obo:UBERON_0003267 obo:IAO_0000115 "A calcareous tooth that is part of the upper jaw region. In mammals, the upper jaw teeth are attached to the maxilla." ; obo:IAO_0000116 "Note that we follow EHDAA2 and consider teeth part of the jaw skeleton" ; oboInOwl:hasDbXref "EHDAA:8045", "EMAPA:17938", "MA:0001909", "NCIT:C49792", "SCTID:422279005", "UMLS:C1710581" ; oboInOwl:hasExactSynonym "upper jaw tooth" ; oboInOwl:hasNarrowSynonym "maxillary tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003267" ; a owl:Class ; rdfs:label "tooth of upper jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009680 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011597 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0003268 obo:IAO_0000115 "A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary)." ; oboInOwl:hasDbXref "EHDAA2:0001029", "EHDAA:8009", "EMAPA:17917", "FMA:321647", "MA:0001907", "NCIT:C49582", "SCTID:422032003", "UMLS:C1708757" ; oboInOwl:hasExactSynonym "calcareous tooth of lower jaw", "lower jaw calcareous tooth", "lower jaw dentine containing tooth", "lower jaw tooth", "lower jaw vertebrate tooth" ; oboInOwl:hasNarrowSynonym "mandibular tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003268" ; a owl:Class ; rdfs:label "tooth of lower jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009679 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004768 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003269 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000486", "EHDAA:2923", "EMAPA:17844" ; oboInOwl:hasExactSynonym "eye skeletal muscle", "eye skeletal muscle tissue", "skeletal muscle tissue of eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye skeletal muscle group" ; oboInOwl:id "UBERON:0003269" ; a owl:Class ; rdfs:label "skeletal muscle tissue of eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003277 obo:IAO_0000115 "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." ; obo:UBPROP_0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" ; obo:UBPROP_0000012 "EMAPA/MA placement unclear. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" ; oboInOwl:hasBroadSynonym "upper jaw" ; oboInOwl:hasDbXref "AAO:0000622", "EHDAA2:0002128", "EHDAA:8041", "EMAPA:17927", "FMA:54397", "MA:0001908", "VHOG:0000429", "XAO:0003087" ; oboInOwl:hasExactSynonym "upper jaw skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003277" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skeleton of upper jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0003278 obo:IAO_0000115 "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." ; obo:UBPROP_0000001 "The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO]" ; obo:UBPROP_0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" ; obo:UBPROP_0000012 "Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" ; oboInOwl:hasBroadSynonym "lower jaw", "mandible" ; oboInOwl:hasDbXref "AAO:0000274", "EHDAA2:0004606", "EHDAA:8005", "EMAPA:17906", "EMAPA:17910", "FMA:54398", "MA:0001906", "TAO:0001273", "VHOG:0000428", "XAO:0003084", "ZFA:0001273" ; oboInOwl:hasExactSynonym "lower jaw skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibles", "mandibular series" ; oboInOwl:id "UBERON:0003278" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skeleton of lower jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ], _:genid127258, _:genid127260 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003279 obo:IAO_0000115 "An endothelium that is part of a trachea." ; oboInOwl:hasDbXref "EHDAA:3082", "RETIRED_EHDAA2:0002068" ; oboInOwl:hasExactSynonym "endothelium of windpipe", "trachea endothelium", "windpipe endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003279" ; a owl:Class ; rdfs:label "endothelium of trachea" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0003281 obo:IAO_0000115 "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." ; obo:IAO_0000116 "TODO - check primitive vs developed" ; obo:UBPROP_0000001 "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. [TFD][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001922", "EHDAA:2999", "EMAPA:17024", "MA:0001617", "SCTID:261623000", "VHOG:0000358" ; oboInOwl:hasExactSynonym "mesentery of ventriculus", "mesogaster", "mesogastium", "mesogastrium", "stomach mesentery", "ventriculus mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003281" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mesentery of stomach" ; rdfs:subClassOf obo:UBERON_0004854, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000945 ], _:genid127284 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0003282 obo:IAO_0000115 "A mesentery that surrounds the heart." ; oboInOwl:hasDbXref "EHDAA:432", "EMAPA:16212", "RETIRED_EHDAA2:0000739", "VHOG:0000353" ; oboInOwl:hasExactSynonym "heart mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac mesentery", "mesocardium" ; oboInOwl:id "UBERON:0003282" ; a owl:Class ; rdfs:label "mesentery of heart" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0003283 obo:IAO_0000115 "A mesentery that is part of a esophagus [Automatically generated definition]." ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001288", "EHDAA:2943", "EMAPA:16836", "MA:0001569", "VHOG:0000415" ; oboInOwl:hasExactSynonym "esophagus mesentery", "gullet mesentery", "mesentery of esophagus", "mesentery of gullet", "meso-esophagus", "oesophagus mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003283" ; a owl:Class ; rdfs:label "mesentery of oesophagus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0003284 obo:IAO_0000115 "A mesentery that is part of a midgut [Automatically generated definition]." ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001202", "EHDAA:3031", "EMAPA:16721", "EMAPA:17039", "EMAPA:17197", "VHOG:0000413" ; oboInOwl:hasExactSynonym "midgut mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003284" ; a owl:Class ; rdfs:label "mesentery of midgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0003288 obo:IAO_0000115 "A meninx that is part of a midbrain [Automatically generated definition]." ; obo:IAO_0000116 "consider changing genus to subdivision of meninx" ; obo:UBPROP_0000001 "Meninges that are part of the midbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001174", "EHDAA:3708", "EMAPA:17791", "MA:0001058", "RETIRED_EHDAA2:0001109", "VHOG:0000012" ; oboInOwl:hasExactSynonym "meninges of midbrain", "midbrain meninges", "midbrain meninx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalon meninges" ; oboInOwl:id "UBERON:0003288" ; a owl:Class ; rdfs:label "meninx of midbrain" ; owl:equivalentClass _:genid126275 . obo:UBERON_0003289 obo:IAO_0000115 "A meninx that is part of a telencephalon [Automatically generated definition]." ; obo:IAO_0000116 "consider changing genus to subdivision of meninx" ; obo:UBPROP_0000001 "Meninges that are part of the telencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001990", "EHDAA:5476", "EMAPA:17774", "MA:0000979", "VHOG:0000010" ; oboInOwl:hasExactSynonym "meninges of telencephalon", "telencephalon meninges", "telencephalon meninx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003289" ; a owl:Class ; rdfs:label "meninx of telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002360 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0003290 obo:IAO_0000115 "A meninx that is part of a diencephalon [Automatically generated definition]." ; obo:IAO_0000116 "consider changing genus to subdivision of meninx" ; obo:UBPROP_0000001 "Meninges that are part of the diencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000399", "EHDAA:5458", "EMAPA:17764", "MA:0000826", "VHOG:0000009" ; oboInOwl:hasExactSynonym "between brain meninges", "between brain meninx", "diencephalon meninges", "diencephalon meninx", "interbrain meninges", "interbrain meninx", "mature diencephalon meninges", "mature diencephalon meninx", "meninges of between brain", "meninges of diencephalon", "meninges of interbrain", "meninges of mature diencephalon", "meninx of between brain", "meninx of interbrain", "meninx of mature diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003290" ; a owl:Class ; rdfs:label "meninx of diencephalon" ; owl:equivalentClass _:genid126296 . obo:UBERON_0003291 obo:IAO_0000115 "A meninx that is part of a hindbrain [Automatically generated definition]." ; obo:IAO_0000116 "consider changing genus to subdivision of meninx" ; obo:UBPROP_0000001 "Meninges that are part of the hindbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000770", "EHDAA:3688", "EMAPA:17783", "MA:0000987", "VHOG:0000011" ; oboInOwl:hasExactSynonym "hindbrain meninges", "hindbrain meninx", "meninges of hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhomencephalon meninges" ; oboInOwl:id "UBERON:0003291" ; a owl:Class ; rdfs:label "meninx of hindbrain" ; rdfs:subClassOf _:genid127368 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002360 _:genid126320 ) ] . obo:UBERON_0003292 obo:IAO_0000115 "A meninx that is part of a spinal cord [Automatically generated definition]." ; obo:UBPROP_0000001 "Meninges that are part of the spinal cord. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "CALOHA:TS-2148", "EHDAA2:0001895", "EHDAA:2865", "EMAPA:17804", "MA:0001130", "NCIT:C12350", "SCTID:181097002", "UMLS:C0037938", "VHOG:0000443" ; oboInOwl:hasExactSynonym "menines of spinal cord", "meninges of spinal cord", "spinal cord meninges", "spinal cord meninx", "spinal meninges", "spinal meninx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003292" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "meninx of spinal cord" ; owl:equivalentClass _:genid126330 . obo:UBERON_0003294 obo:IAO_0000115 "A gland that is part of a foregut [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000567", "EHDAA:950", "EMAPA:16557", "VHOG:0000650" ; oboInOwl:hasExactSynonym "foregut gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003294" ; a owl:Class ; rdfs:label "gland of foregut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 ] ) ] . obo:UBERON_0003295 obo:IAO_0000115 "Racemose mucous glands beneath the mucous membrane of the pharynx." ; oboInOwl:hasDbXref "BTO:0004849", "EHDAA2:0001461", "EHDAA:2967", "FMA:55075" ; oboInOwl:hasExactSynonym "pharynx gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandulae pharyngeae" ; oboInOwl:id "UBERON:0003295" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "pharyngeal gland" ; rdfs:subClassOf _:genid127400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0003296 obo:IAO_0000115 "Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis." ; oboInOwl:hasDbXref "EHDAA2:0000395", "EHDAA:4475", "EMAPA:16897", "VHOG:0000653" ; oboInOwl:hasExactSynonym "diencephalon gland", "interbrain gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003296" ; a owl:Class ; rdfs:label "gland of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0003297 obo:IAO_0000115 "A gland that is part of a integumental system [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000837", "EHDAA:6522", "EMAPA:17758", "MA:0000144", "VHOG:0000654" ; oboInOwl:hasExactSynonym "integumental gland", "integumental system gland", "integumentary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003297" ; a owl:Class ; rdfs:label "gland of integumental system" ; owl:equivalentClass _:genid126364 . obo:UBERON_0003299 obo:IAO_0000115 "The mesencephalic roof plate, including the caudal and rostral part of the midbrain roof." ; obo:UBPROP_0000001 "Roof plate that is part of the midbrain. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "DHBA:12320", "EHDAA2:0001177", "EHDAA:3712", "EMAPA:16981", "RETIRED_EHDAA2:0001111", "TAO:0000355", "VHOG:0000772", "ZFA:0000355" ; oboInOwl:hasExactSynonym "midbrain roof plate", "midbrain roofplate", "roof plate midbrain", "roof plate midbrain region", "roofplate of midbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "midbrain roof", "roof plate mesencephalon", "roofplate midbrain" ; oboInOwl:id "UBERON:0003299" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "roof plate of midbrain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001891 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0003300 obo:IAO_0000115 "A roof plate that is part of a telencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Roof plate that is part of the telencephalon. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001994", "EHDAA:3512", "EMAPA:16657", "VHOG:0000774" ; oboInOwl:hasExactSynonym "roof plate telencephalon", "roofplate of telencephalon", "telencephalon roof plate", "telencephalon roofplate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "roofplate medulla telencephalon" ; oboInOwl:id "UBERON:0003300" ; a owl:Class ; rdfs:label "roof plate of telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0003301 obo:IAO_0000115 "A roof plate that is part of a diencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Roof plate that is part of the diencephalon. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000402", "EHDAA:1979", "EHDAA:2657", "EHDAA:3494", "EMAPA:16909", "TAO:0001358", "VHOG:0000771", "ZFA:0001358" ; oboInOwl:hasExactSynonym "between brain roof plate", "between brain roofplate", "diencephalon roof plate", "diencephalon roofplate", "interbrain roof plate", "interbrain roofplate", "mature diencephalon roof plate", "mature diencephalon roofplate", "roof plate diencephalic region", "roof plate diencephalon", "roof plate of between brain", "roof plate of interbrain", "roof plate of mature diencephalon", "roofplate of between brain", "roofplate of diencephalon", "roofplate of interbrain", "roofplate of mature diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "roofplate medulla diencephalon" ; oboInOwl:id "UBERON:0003301" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "roof plate of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0003302 obo:IAO_0000115 "A roof plate that is part of a metencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Roof plate that is part of the metencephalon. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001160", "EHDAA:5524", "EMAPA:16483", "EMAPA:16487", "VHOG:0000770" ; oboInOwl:hasExactSynonym "epencephalon-2 roof plate", "epencephalon-2 roofplate", "metencephalon roof plate", "metencephalon roofplate", "roof plate metencephalon", "roof plate of epencephalon-2", "roofplate of epencephalon-2", "roofplate of metencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "roofplate medulla metencephalon" ; oboInOwl:id "UBERON:0003302" ; a owl:Class ; rdfs:label "roof plate of metencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 _:genid126430 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0003303 obo:IAO_0000115 "A roof plate that is part of a medulla oblongata [Automatically generated definition]." ; obo:UBPROP_0000001 "Roof plate that is part of the medulla oblongata. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001099", "EHDAA:7614", "VHOG:0000776" ; oboInOwl:hasExactSynonym "bulb roof plate", "bulb roofplate", "medulla oblongata roof plate", "medulla oblongata roofplate", "medulla oblonmgata roof plate", "medulla oblonmgata roofplate", "metepencephalon roof plate", "metepencephalon roofplate", "roof plate medulla oblongata", "roof plate of bulb", "roof plate of medulla oblonmgata", "roof plate of metepencephalon", "roofplate of bulb", "roofplate of medulla oblongata", "roofplate of medulla oblonmgata", "roofplate of metepencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "roofplate medulla oblongata" ; oboInOwl:id "UBERON:0003303" ; a owl:Class ; rdfs:label "roof plate of medulla oblongata" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0003304 obo:IAO_0000115 "A blood island that is part of a mesoderm." ; obo:UBPROP_0000012 "in EHDAA2, gives rise to blood and dorsal aorta" ; oboInOwl:hasAlternativeId "UBERON:0003305" ; oboInOwl:hasDbXref "EHDAA2:0003241", "EHDAA:170", "EMAPA:16115" ; oboInOwl:hasExactSynonym "mesoderm blood islands" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesenchyme blood island" ; oboInOwl:id "UBERON:0003304" ; a owl:Class ; rdfs:label "mesoderm blood island" ; rdfs:subClassOf obo:UBERON_0007503, _:genid127523, _:genid127525 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ] . obo:UBERON_0003312 obo:IAO_0000115 "Mesenchyme that is part of a developing testis [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002010", "EHDAA:8150", "EMAPA:35858", "VHOG:0001442" ; oboInOwl:hasExactSynonym "testis mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003312" ; a owl:Class ; rdfs:label "mesenchyme of testis" ; owl:equivalentClass _:genid126481 . obo:UBERON_0003314 obo:IAO_0000115 "Mesenchyme that is part of a developing camera-type eye." ; obo:IAO_0000116 "TODO - change mesenchyme relationships to precursor_of" ; oboInOwl:hasDbXref "EHDAA2:0000485", "EHDAA:2910", "EMAPA:16673", "VHOG:0001084" ; oboInOwl:hasExactSynonym "mesenchyme of eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003314" ; a owl:Class ; rdfs:label "eye mesenchyme" ; rdfs:subClassOf _:genid127541 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003315 obo:IAO_0000115 "Mesenchyme that is part of a developing ovary [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001362", "EHDAA:8128", "VHOG:0001441" ; oboInOwl:hasExactSynonym "female reproductive system gonad mesenchyme", "female reproductive system gonada mesenchyme", "gonad of female reproductive system mesenchyme", "gonada of female reproductive system mesenchyme", "mesenchyme of female reproductive system gonad", "mesenchyme of female reproductive system gonada", "mesenchyme of gonad of female reproductive system", "mesenchyme of gonada of female reproductive system", "ovary mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003315" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesenchyme of ovary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0003316 obo:IAO_0000115 "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." ; oboInOwl:hasAlternativeId "UBERON:0003264" ; oboInOwl:hasDbXref "EHDAA2:0002216", "EHDAA:168", "EHDAA:205", "EMAPA:16087", "EMAPA:16267", "VHOG:0000503", "VHOG:0000617" ; oboInOwl:hasExactSynonym "yolk sac mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003316" ; a owl:Class ; rdfs:label "mesenchyme of yolk sac" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid126509 ] . obo:UBERON_0003317 obo:IAO_0000115 "An odontogenic papilla that is part of a incisor tooth [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32893", "MA:0003231" ; oboInOwl:hasExactSynonym "incisor dental papilla", "incisor odontogenic papilla", "incisor tooth odontogenic papilla", "odontogenic papilla of incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003317" ; a owl:Class ; rdfs:label "odontogenic papilla of incisor" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015846 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0003318 obo:IAO_0000115 "Mesenchyme that is part of a developing elbow [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000432", "EHDAA:4170", "EHDAA:6216", "EMAPA:17416", "VHOG:0001075" ; oboInOwl:hasExactSynonym "cubital region mesenchyme", "elbow mesenchyme", "mesenchyme of cubital region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003318" ; a owl:Class ; rdfs:label "mesenchyme of elbow" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] . obo:UBERON_0003319 obo:IAO_0000115 "Mesenchyme of the carpal region that contributes to the carpal skeleton." ; oboInOwl:hasDbXref "EHDAA2:0000220", "EHDAA:5200", "EMAPA:19122" ; oboInOwl:hasExactSynonym "carpal region mesenchyme", "carpus mesenchyme", "mesenchyme of wrist", "wrist mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003319" ; a owl:Class ; rdfs:label "mesenchyme of carpal region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] . obo:UBERON_0003320 obo:IAO_0000115 "Mesenchyme that is part of a developing hip [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000786", "EHDAA:5157", "EHDAA:6182", "EMAPA:17492", "VHOG:0001029" ; oboInOwl:hasExactSynonym "hip mesenchyme", "hip region mesenchyme", "mesenchyme of hip region", "mesenchyme of regio coxae", "regio coxae mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003320" ; a owl:Class ; rdfs:label "mesenchyme of hip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid126543 ) ] . obo:UBERON_0003321 obo:IAO_0000115 "Mesenchyme that is part of a developing knee [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000898", "EHDAA:5163", "EHDAA:6188", "EMAPA:17495", "VHOG:0001070" ; oboInOwl:hasExactSynonym "knee mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003321" ; a owl:Class ; rdfs:label "mesenchyme of knee" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] . obo:UBERON_0003322 obo:IAO_0000115 "Mesenchyme that is part of a developing shoulder [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001837", "EHDAA:4184", "EHDAA:6232", "EMAPA:17423", "VHOG:0001035" ; oboInOwl:hasExactSynonym "shoulder mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003322" ; a owl:Class ; rdfs:label "mesenchyme of shoulder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0003323 obo:IAO_0000115 "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002124", "EHDAA:8031", "EMAPA:17929", "VHOG:0001099" ; oboInOwl:hasExactSynonym "mesenchyme of palatoquadrate arch", "palatoquadrate arch mesenchyme", "upper jaw mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003323" ; a owl:Class ; rdfs:label "mesenchyme of upper jaw" ; rdfs:subClassOf _:genid127618 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid126564 ] . obo:UBERON_0003324 obo:IAO_0000115 "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001024", "EHDAA:8003", "EMAPA:17916", "VHOG:0001069" ; oboInOwl:hasExactSynonym "lower jaw mesenchyme", "mesenchyme of ventral mandibular arch", "ventral mandibular arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003324" ; a owl:Class ; rdfs:label "mesenchyme of lower jaw" ; rdfs:subClassOf _:genid127628 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003325 obo:IAO_0000115 "Mesenchyme that is part of a developing pinna [Automatically generated definition]." ; obo:UBPROP_0000012 "EMAPA divides this spatially into condensation + rest, and temporally into mesenchyme and cartilage condensation" ; oboInOwl:hasDbXref "EHDAA2:0001469", "EHDAA:8981", "EMAPA:17591", "VHOG:0000747" ; oboInOwl:hasExactSynonym "auricle mesenchyme", "auricle of ear mesenchyme", "auricle of external ear mesenchyme", "auricula (auris externa) mesenchyme", "auricula mesenchyme", "mesenchyme of auricle", "mesenchyme of auricle of ear", "mesenchyme of auricle of external ear", "mesenchyme of auricula", "mesenchyme of auricula (auris externa)", "mesenchyme of pinna of ear", "pinna mesenchyme", "pinna of ear mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003325" ; a owl:Class ; rdfs:label "mesenchyme of pinna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ] ) ] . obo:UBERON_0003326 obo:IAO_0000115 "Mesenchyme that is part of a developing mammary gland." ; oboInOwl:hasDbXref "EHDAA2:0001058", "EHDAA:6528", "EMAPA:17761", "VHOG:0001087" ; oboInOwl:hasExactSynonym "lactiferous gland mesenchyme", "lobe of breast mesenchyme", "lobe of mammary gland mesenchyme", "mammary gland mesenchyme", "mammary mesenchyme", "mesenchyme of lactiferous gland", "mesenchyme of lobe of breast", "mesenchyme of lobe of mammary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003326" ; a owl:Class ; rdfs:label "mesenchyme of mammary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid126601 ] . obo:UBERON_0003327 obo:IAO_0000115 "Mesenchyme that is part of a developing lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000555", "EHDAA:4176", "EHDAA:6222", "EMAPA:17419", "VHOG:0000504" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003327" ; a owl:Class ; rdfs:label "mesenchyme of forearm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0003328 obo:IAO_0000115 "Mesenchyme that is part of a footplate." ; obo:UBPROP_0000012 "We group two EMAPA classes here but these may need to be separated" ; oboInOwl:hasAlternativeId "UBERON:0005260" ; oboInOwl:hasDbXref "EHDAA2:0000549", "EHDAA:5149", "EHDAA:6172", "EMAPA:17252", "EMAPA:17488", "VHOG_RETIRED:0001055" ; oboInOwl:hasExactSynonym "foot plate mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003328" ; a owl:Class ; rdfs:label "mesenchyme of footplate" ; rdfs:subClassOf _:genid127674 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006871 ] ) ] . obo:UBERON_0003329 obo:IAO_0000115 "A submucosa that is part of an anal canal [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27217", "EMAPA:27227", "EMAPA:27535", "FMA:85399", "SCTID:7892006" ; oboInOwl:hasExactSynonym "anal canal submucosa", "anal canal viewed anatomically submucosa", "anal region submucosa", "anatomical anal canal submucosa", "submucosa of anal canal viewed anatomically", "submucosa of anal region", "submucosa of anatomical anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003329" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of anal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0003330 obo:IAO_0000115 "The submucous layer of the wall of the rectum." ; oboInOwl:hasDbXref "BTO:0002114", "EMAPA:27083", "FMA:15034", "SCTID:71683001" ; oboInOwl:hasExactSynonym "rectal submucosa", "rectum submucosa", "tela submucosa recti" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003330" ; a owl:Class ; rdfs:label "submucosa of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0003331 obo:IAO_0000115 "A submucosa that is part of a colon [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27379", "FMA:14985", "MA:0003200", "SCTID:61647009" ; oboInOwl:hasExactSynonym "colon submucosa", "colonic submucosa", "large bowel submucosa", "submucosa of large bowel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003331" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0003332 obo:IAO_0000115 "A submucosa that is part of a duodenum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27027", "EMAPA:27097", "EMAPA:27239", "FMA:14943", "MA:0003213", "SCTID:76519004" ; oboInOwl:hasExactSynonym "doudenal submucosa", "duodenal submucosa", "duodenum submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003332" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of duodenum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0003333 obo:IAO_0000115 "A submucosa that is part of a jejunum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27111", "FMA:14950", "SCTID:70192009" ; oboInOwl:hasExactSynonym "jejunal submucosa", "jejunum submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003333" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of jejunum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0003334 obo:IAO_0000115 "A serous membrane that is part of a rectum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27087", "FMA:15039" ; oboInOwl:hasExactSynonym "rectal serosa", "rectum serosa", "rectum serous membrane", "serous membrane of rectum", "visceral peritoneum of rectum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003334" ; a owl:Class ; rdfs:label "serosa of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0003335 obo:IAO_0000115 "A serous membrane that is part of a colon [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27387", "FMA:14990", "MA:0003199", "SCTID:90132000" ; oboInOwl:hasExactSynonym "colon serosa", "colon serous membrane", "colonic serosa", "large bowel serosa", "large bowel serous membrane", "serosa of large bowel", "serous membrane of colon", "serous membrane of large bowel", "visceral peritoneum of colon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003335" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "serosa of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid126679 ] . obo:UBERON_0003336 obo:IAO_0000115 "A serous membrane that is part of a duodenum [Automatically generated definition]." ; obo:UBPROP_0000010 "1st part serosa, 2nd - 4th adventitia" ; oboInOwl:hasDbXref "EMAPA:27247", "FMA:14948", "MA:0003212", "SCTID:1236009" ; oboInOwl:hasExactSynonym "doudenal serosa", "duodenal serosa", "duodenum serosa", "duodenum serous membrane", "serous membrane of duodenum", "visceral peritoneum of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003336" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "serosa of duodenum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0003337 obo:IAO_0000115 "A serous membrane that is part of a jejunum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27115", "FMA:14955" ; oboInOwl:hasExactSynonym "jejunal serosa", "jejunum serosa", "jejunum serous membrane", "serous membrane of jejunum", "visceral peritoneum of jejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003337" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "serosa of jejunum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0003338 obo:IAO_0000115 "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." ; obo:UBPROP_0000012 "we follow MA in including separate classes for ganglion and peripheral nervous system, even though for vertebrates gangia are always in the PNS" ; oboInOwl:hasDbXref "BIRNLEX:2548", "BTO:0001123", "EMAPA:32814", "MA:0001161" ; oboInOwl:hasExactSynonym "peripheral nervous system ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003338" ; oboInOwl:inSubset core:cumbo ; a owl:Class ; rdfs:label "ganglion of peripheral nervous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ) ] . obo:UBERON_0003339 obo:IAO_0000115 "A ganglion that is part of a central nervous system [Automatically generated definition]." ; obo:UBPROP_0000012 "this has no subclasses in FMA. In EHDAA2 and EMAPA it has only the cranial ganglia" ; oboInOwl:hasDbXref "EHDAA2:0000227", "EMAPA:16658", "FMA:83843" ; oboInOwl:hasExactSynonym "central nervous system ganglion", "ganglion of neuraxis", "neuraxis ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003339" ; a owl:Class ; rdfs:label "ganglion of central nervous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0003342 obo:IAO_0000115 "A mucosa that is part of an anal canal [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27531", "FMA:74654", "NCIT:C60784", "SCTID:362170004", "UMLS:C0227414" ; oboInOwl:hasExactSynonym "anal canal mucosa", "anal canal mucosa of organ", "anal canal mucous membrane", "anal canal organ mucosa", "anal canal viewed anatomically mucosa", "anal canal viewed anatomically mucosa of organ", "anal canal viewed anatomically mucous membrane", "anal canal viewed anatomically organ mucosa", "anal mucosa", "anal mucous membrane", "anal region mucosa", "anal region mucosa of organ", "anal region mucous membrane", "anal region organ mucosa", "anatomical anal canal mucosa", "anatomical anal canal mucosa of organ", "anatomical anal canal mucous membrane", "anatomical anal canal organ mucosa", "mucosa of anal canal viewed anatomically", "mucosa of anal region", "mucosa of anatomical anal canal", "mucosa of organ of anal canal", "mucosa of organ of anal canal viewed anatomically", "mucosa of organ of anal region", "mucosa of organ of anatomical anal canal", "mucous membrane of anal canal", "mucous membrane of anal canal viewed anatomically", "mucous membrane of anal region", "mucous membrane of anatomical anal canal", "organ mucosa of anal canal", "organ mucosa of anal canal viewed anatomically", "organ mucosa of anal region", "organ mucosa of anatomical anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003342" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mucosa of anal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0003343 obo:IAO_0000115 "A mucosa that is part of a oral opening [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:26937", "SCTID:362083000" ; oboInOwl:hasExactSynonym "mucosa of oral opening", "mucosa of oral part of face", "mucosa of organ of oral opening", "mucosa of organ of oral part of face", "mucosa of organ of oral region", "mucosa of organ of subdivision of mouth", "mucosa of subdivision of mouth", "mucous membrane of oral opening", "mucous membrane of oral part of face", "mucous membrane of oral region", "mucous membrane of subdivision of mouth", "oral opening mucosa", "oral opening mucosa of organ", "oral opening mucous membrane", "oral opening organ mucosa", "oral part of face mucosa", "oral part of face mucosa of organ", "oral part of face mucous membrane", "oral part of face organ mucosa", "oral region mucosa", "oral region mucosa of organ", "oral region mucous membrane", "oral region organ mucosa", "organ mucosa of oral opening", "organ mucosa of oral part of face", "organ mucosa of oral region", "organ mucosa of subdivision of mouth", "subdivision of mouth mucosa", "subdivision of mouth mucosa of organ", "subdivision of mouth mucous membrane", "subdivision of mouth organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003343" ; a owl:Class ; rdfs:label "mucosa of oral region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000166 ] ) ] . obo:UBERON_0003346 obo:IAO_0000115 "A mucosa that is part of a rectum [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-2107", "EMAPA:27081", "FMA:15033", "MA:0003218", "SCTID:362167003" ; oboInOwl:hasExactSynonym "mucosa of organ of rectum", "mucous membrane of rectum", "organ mucosa of rectum", "rectal mucosa", "rectal mucous membrane", "rectum mucosa", "rectum mucosa of organ", "rectum mucous membrane", "rectum organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003346" ; a owl:Class ; rdfs:label "mucosa of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0003350 obo:IAO_0000115 "A layer of epithelial cells on the surface of the mucosa." ; oboInOwl:hasDbXref "BTO:0003752" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lamina epithelialis mucosa", "lamina epithelialis mucosae" ; oboInOwl:id "UBERON:0003350" ; a owl:Class ; rdfs:comment "lies on top of lamina propria" ; rdfs:label "epithelium of mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000344 ] ) ] . obo:UBERON_0003351 obo:IAO_0000115 "An epithelium that is part of a pharynx [Automatically generated definition]." ; obo:UBPROP_0000001 "Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO]" ; oboInOwl:hasDbXref "BSA:0000112", "BTO:0005240", "EMAPA:16708", "MA:0002725", "RETIRED_EHDAA2:0001460", "TAO:0001174", "XAO:0003202", "ZFA:0001174" ; oboInOwl:hasExactSynonym "epithelial tissue of pharynx", "epithelium of pharynx", "pharynx epithelial tissue", "pharynx epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003351" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal epithelium" ; rdfs:subClassOf _:genid127883, _:genid127885 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0003352 obo:IAO_0000115 "An epithelium that is part of a midgut." ; oboInOwl:hasDbXref "BTO:0005053", "EHDAA2:0001195", "EMAPA:16569", "MA:0003205" ; oboInOwl:hasExactSynonym "epithelial tissue of midgut", "midgut epithelial tissue", "midgut epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003352" ; a owl:Class ; rdfs:label "epithelium of midgut" ; rdfs:subClassOf _:genid127897 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0003353 obo:IAO_0000115 "An epithelium that is part of a hindgut [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000782", "EMAPA:16717", "MA:0003206" ; oboInOwl:hasExactSynonym "epithelial tissue of hindgut", "hindgut epithelial tissue", "hindgut epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003353" ; a owl:Class ; rdfs:label "epithelium of hindgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001046 ] ) ] . obo:UBERON_0003354 obo:IAO_0000115 "An epithelium that is part of a rectum [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-2066", "EHDAA2:0001594", "EMAPA:17898", "FMA:17510", "MA:0003219", "VHOG:0001037" ; oboInOwl:hasExactSynonym "epithelial tissue of rectum", "rectal epithelium", "rectum epithelial tissue", "rectum epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003354" ; a owl:Class ; rdfs:label "epithelium of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0003355 obo:IAO_0000115 "An epithelium that is part of a incisor tooth [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32890", "MA:0003223" ; oboInOwl:hasExactSynonym "epithelial tissue of incisor", "epithelial tissue of incisor tooth", "epithelium of incisor tooth", "incisor epithelial tissue", "incisor epithelium", "incisor tooth epithelial tissue", "incisor tooth epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003355" ; a owl:Class ; rdfs:label "epithelium of incisor" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0003356 obo:IAO_0000115 "An epithelium that is part of a nasal septum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18442" ; oboInOwl:hasExactSynonym "epithelial tissue of nasal septum", "nasal septum epithelial tissue", "nasal septum epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003356" ; a owl:Class ; rdfs:label "epithelium of nasal septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001706 ] ) ] . obo:UBERON_0003357 obo:IAO_0000115 "An epithelium that is part of a tongue [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0000992", "CALOHA:TS-1051", "EHDAA2:0004598", "EMAPA:17881", "FMA:284658", "MA:0001592", "NCIT:C49300", "UMLS:C1710436" ; oboInOwl:hasExactSynonym "epithelial tissue of tongue", "tongue epithelial tissue", "tongue epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lingual epithelium" ; oboInOwl:id "UBERON:0003357" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "examples: tongue squamous epithelium, keratined, non-keratinized and parakeratinized epithelium, as well as gustatory epithelium. Note that not all these subtypes are named in individual anatomy ontologies." ; rdfs:label "epithelium of tongue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001723 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0003358 obo:IAO_0000115 "An epithelium that is part of a soft palate [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18950" ; oboInOwl:hasExactSynonym "epithelial tissue of soft palate", "soft palate epithelial tissue", "soft palate epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003358" ; a owl:Class ; rdfs:label "epithelium of soft palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ] ) ] . obo:UBERON_0003359 obo:IAO_0000115 "An epithelium that is part of a submandibular gland [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004557", "EMAPA:18813", "VHOG:0000989" ; oboInOwl:hasExactSynonym "epithelial tissue of submandibular gland", "submandibular gland epithelial tissue", "submandibular gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submandibular duct epithelium", "submandibular gland duct epithelium", "submaxillary gland epithelium" ; oboInOwl:id "UBERON:0003359" ; a owl:Class ; rdfs:label "epithelium of submandibular gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001736 ] ) ] . obo:UBERON_0003360 obo:IAO_0000115 "An epithelium that is part of a parotid gland [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004555", "EMAPA:18538", "VHOG:0001434" ; oboInOwl:hasExactSynonym "epithelial tissue of parotid gland", "epithelium of parotid", "epithelium of parotid gland", "parotid epithelial tissue", "parotid epithelium", "parotid gland epithelial tissue", "parotid gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parotid gland duct epithelium" ; oboInOwl:id "UBERON:0003360" ; a owl:Class ; rdfs:label "epithelium of parotid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0003361 obo:IAO_0000115 "An epithelium that is part of a sublingual gland [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004559", "EMAPA:18810", "VHOG:0001098" ; oboInOwl:hasExactSynonym "Rivinus'gland epithelial tissue", "Rivinus'gland epithelium", "ductus sublingualis epithelial tissue", "ductus sublingualis epithelium", "epithelial tissue of Rivinus'gland", "epithelial tissue of ductus sublingualis", "epithelial tissue of sublingual gland", "epithelium of Rivinus'gland", "epithelium of ductus sublingualis", "sublingual gland epithelial tissue", "sublingual gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sublingual duct epithelium", "sublingual gland duct epithelium" ; oboInOwl:id "UBERON:0003361" ; a owl:Class ; rdfs:label "epithelium of sublingual gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001832 ] ) ] . obo:UBERON_0003364 obo:IAO_0000115 "An epithelium that is part of a right lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17663", "MA:0003132" ; oboInOwl:hasExactSynonym "epithelial tissue of right lung", "right lung epithelial tissue", "right lung epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003364" ; a owl:Class ; rdfs:label "epithelium of right lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0003365 obo:IAO_0000115 "An epithelium that is part of a left lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17655", "MA:0003131" ; oboInOwl:hasExactSynonym "epithelial tissue of left lung", "left lung epithelial tissue", "left lung epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003365" ; a owl:Class ; rdfs:label "epithelium of left lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0003368 obo:IAO_0000115 "An epithelium that is part of a hard palate [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18953" ; oboInOwl:hasExactSynonym "epithelial tissue of hard palate", "hard palate epithelial tissue", "hard palate epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003368" ; a owl:Class ; rdfs:label "epithelium of hard palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003216 ] ) ] . obo:UBERON_0003371 obo:IAO_0000115 "An unilaminar epithelium that surrounds a pelvic appendage bud." ; oboInOwl:hasAlternativeId "UBERON:0005232" ; oboInOwl:hasDbXref "EHDAA2:0001034", "EMAPA:16780", "VHOG:0001048" ; oboInOwl:hasExactSynonym "hindlimb ectoderm" ; oboInOwl:hasNarrowSynonym "hindlimb bud ectoderm", "hindlimb ectoderm", "lower limb bud ectoderm", "pelvic fin bud ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "leg ectoderm" ; oboInOwl:id "UBERON:0003371" ; a owl:Class ; rdfs:label "pelvic appendage bud ectoderm" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005420 ], _:genid128029, _:genid128032 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0005420 ] ) ] . obo:UBERON_0003372 obo:IAO_0000115 "An unilaminar epithelium that surrounds a pectoral appendage bud." ; oboInOwl:hasAlternativeId "UBERON:0005231", "UBERON:0005663" ; oboInOwl:hasDbXref "EHDAA2:0002134", "EMAPA:16407", "VHOG:0001047" ; oboInOwl:hasNarrowSynonym "forelimb bud ectoderm", "forelimb ectoderm", "pectoral fin bud ectoderm", "upper limb bud ectoderm", "wing ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm ectoderm" ; oboInOwl:id "UBERON:0003372" ; a owl:Class ; rdfs:label "pectoral appendage bud ectoderm" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005419 ], _:genid128045, _:genid128048 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0005419 ] ) ] . obo:UBERON_0003373 obo:IAO_0000115 "An ectoderm that is part of a footplate." ; oboInOwl:hasDbXref "EMAPA:17250" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003373" ; a owl:Class ; rdfs:label "ectoderm of footplate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006871 ] ) ] . obo:UBERON_0003374 obo:IAO_0000115 "An extraembryonic structure that develops_from a ectoderm and is part of a chorion." ; oboInOwl:hasDbXref "BTO:0005145", "EMAPA:16113" ; oboInOwl:hasExactSynonym "chorion ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chorion epithelium", "chorionic epithelium" ; oboInOwl:id "UBERON:0003374" ; a owl:Class ; rdfs:label "chorionic ectoderm" ; rdfs:subClassOf _:genid128068 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000478 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003124 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0003379 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0004155", "EMAPA:17326", "FMA:7282", "SCTID:362018002", "VHOG:0001227" ; oboInOwl:hasExactSynonym "cardiac muscle of cardiac right atrium", "cardiac muscle of heart right atrium", "cardiac muscle tissue of heart right atrium", "cardiac muscle tissue of right atrium", "cardiac muscle tissue of right atrium of heart", "myocardium of right atrium", "right atrium heart muscle", "right atrium myocardium", "textus muscularis of myocardium of right atrium", "textus muscularis of myocardium of right atrium of heart", "textus muscularis of myocardium of right cardiac atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003379" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cardiac muscle of right atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 _:genid127013 ) ] . obo:UBERON_0003380 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0004154", "EMAPA:17320", "FMA:7285", "SCTID:189936008", "VHOG:0001225" ; oboInOwl:hasExactSynonym "cardiac left atrium cardiac muscle", "cardiac left atrium cardiac muscle tissue", "cardiac muscle of cardiac left atrium", "cardiac muscle of heart left atrium", "cardiac muscle of left atrium of heart", "left atrium heart muscle", "left atrium myocardium", "myocardium of left atrium", "textus muscularis of myocardium of cardiac left atrium", "textus muscularis of myocardium of heart left atrium", "textus muscularis of myocardium of left atrium", "textus muscularis of myocardium of left atrium of heart", "textus muscularis of myocardium of left cardiac atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003380" ; a owl:Class ; rdfs:label "cardiac muscle of left atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002079 ] ) ] . obo:UBERON_0003381 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17342", "FMA:83452", "VHOG:0001236" ; oboInOwl:hasExactSynonym "cardiac muscle tissue of right ventricle", "right ventricular cardiac muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right ventricle cardiac muscle" ; oboInOwl:id "UBERON:0003381" ; a owl:Class ; rdfs:label "cardiac muscle of right ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0003382 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17339", "FMA:83453", "VHOG:0001234" ; oboInOwl:hasExactSynonym "cardiac muscle tissue of left ventricle", "left ventricular cardiac muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "left ventricle cardiac muscle" ; oboInOwl:id "UBERON:0003382" ; a owl:Class ; rdfs:label "cardiac muscle of left ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0003383 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0004158", "EMAPA:17335", "FMA:84084", "VHOG:0000999" ; oboInOwl:hasExactSynonym "cardiac muscle of interventricular septum", "cardiac muscle tissue of interventricular septum", "interventricular septum cardiac muscle", "interventricular septum heart muscle", "interventricular septum myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interventricular septum muscle" ; oboInOwl:id "UBERON:0003383" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cardiac muscle tissue of interventricular septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:UBERON_0003384 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18963" ; oboInOwl:hasExactSynonym "pharynx skeletal muscle", "pharynx skeletal muscle tissue", "skeletal muscle tissue of pharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003384" ; a owl:Class ; rdfs:label "skeletal muscle tissue of pharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0003386 obo:IAO_0000115 "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." ; obo:IAO_0000116 "Not clear if we need this and intra-ocular muscle. See issue #331. MA includes ciliary and iris smooth muscle" ; oboInOwl:hasDbXref "EMAPA:18807", "MA:0001268" ; oboInOwl:hasExactSynonym "ocular smooth muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003386" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "smooth muscle of eye" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001015 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003387 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0004244" ; oboInOwl:hasDbXref "BTO:0001391", "EMAPA:19192", "FMA:262010", "MA:0001863", "NCIT:C49306", "UMLS:C1710458" ; oboInOwl:hasExactSynonym "trachea smooth muscle", "tracheal smooth muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003387" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "smooth muscle of trachea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003126 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0003388 obo:IAO_0000115 "A mesothelium that is part of a pericardium [Automatically generated definition]." ; oboInOwl:hasDbXref "RETIRED_EHDAA2:0001436" ; oboInOwl:hasExactSynonym "cavity of pericardial sac meso-epithelium", "cavity of pericardial sac mesothelium", "meso-epithelium of cavity of pericardial sac", "meso-epithelium of pericardial cavity", "mesothelium of cavity of pericardial sac", "pericardial cavity meso-epithelium", "pericardial cavity mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003388" ; a owl:Class ; rdfs:label "mesothelium of pericardial cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001136 _:genid127095 ) ] . obo:UBERON_0003389 obo:IAO_0000115 "A mesothelium that is part of a diaphragm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18429" ; oboInOwl:hasExactSynonym "diaphragm meso-epithelium", "diaphragm mesothelium", "meso-epithelium of diaphragm", "meso-epithelium of thoracic diaphragm", "mesothelium of thoracic diaphragm", "thoracic diaphragm meso-epithelium", "thoracic diaphragm mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003389" ; a owl:Class ; rdfs:label "mesothelium of diaphragm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] . obo:UBERON_0003390 obo:IAO_0000115 "A mesothelium that is part of a pleural cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0003155", "EHDAA2:0001476", "EMAPA:16775", "FMA:18148" ; oboInOwl:hasExactSynonym "meso-epithelium of pleural cavity", "mesothelium of pleura", "pleural cavity meso-epithelium", "pleural cavity mesothelium", "pleural mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pleura" ; oboInOwl:id "UBERON:0003390" ; a owl:Class ; rdfs:label "mesothelium of pleural cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001136 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002402 ] ) ] . obo:UBERON_0003393 obo:IAO_0000115 "A mesentery that is part of a urinary system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17367", "MA:0003233" ; oboInOwl:hasExactSynonym "excretory system mesentery", "mesentery of excretory system", "mesentery of renal system", "mesentery of systema urinaria", "renal system mesentery", "systema urinaria mesentery", "urinary system mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003393" ; a owl:Class ; rdfs:label "mesentery of urinary system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ] ) ] . obo:UBERON_0003394 obo:IAO_0000115 "A mesentery that is part of a hindgut [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:16718" ; oboInOwl:hasExactSynonym "hindgut mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003394" ; a owl:Class ; rdfs:label "mesentery of hindgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001046 ] ) ] . obo:UBERON_0003395 obo:IAO_0000115 "A mesentery that is part of a rectum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18664" ; oboInOwl:hasExactSynonym "rectum mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003395" ; a owl:Class ; rdfs:label "mesentery of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0003396 obo:IAO_0000115 "A mesentery that is part of a colon [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18942", "FMA:14645", "SCTID:245457004" ; oboInOwl:hasExactSynonym "colon mesentery", "large bowel mesentery", "large intestinal mesentery", "mesentery of large bowel", "mesentery of large intestine", "mesocolon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003396" ; a owl:Class ; rdfs:label "mesentery of colon" ; rdfs:subClassOf obo:UBERON_0007826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0003397 obo:IAO_0000115 "A mesentery that is part of a duodenum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19081" ; oboInOwl:hasExactSynonym "duodenum mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003397" ; a owl:Class ; rdfs:label "mesentery of duodenum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0003398 obo:IAO_0000115 "A mesentery that is part of a jejunum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18670", "FMA:14651", "SCTID:261286003" ; oboInOwl:hasExactSynonym "jejunal mesentery", "jejunum mesentery", "mesojejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003398" ; a owl:Class ; rdfs:label "mesentery of jejunum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0003403 obo:IAO_0000115 "A zone of skin that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18056", "FMA:38265", "MA:0000602", "SCTID:181537008" ; oboInOwl:hasExactSynonym "forearm skin", "lower arm skin", "lower segment of arm skin", "skin of antebrachial region", "skin of lower arm", "skin of lower segment of arm", "skin of zeugopod of arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003403" ; a owl:Class ; rdfs:label "skin of forearm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0003406 obo:IAO_0000115 "A cartilage element that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18694", "MA:0001818" ; oboInOwl:hasExactSynonym "apparatus respiratorius cartilage", "cartilage of apparatus respiratorius", "respiratory system cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003406" ; a owl:Class ; rdfs:label "cartilage of respiratory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003407 obo:IAO_0000115 "A cartilage that is part of a nasal septum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:25091", "FMA:59503", "MA:0003138" ; oboInOwl:hasExactSynonym "cartilago septal nasi", "nasal septum cartilage", "septal nasal cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003407" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cartilage of nasal septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001706 ] ) ] . obo:UBERON_0003408 obo:IAO_0000115 "A gland that is part of a digestive tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18815", "MA:0003202" ; oboInOwl:hasExactSynonym "digestive tract gland", "gland of digestive tract", "gland of lower gastrointestinal tract", "gut gland", "lower gastrointestinal tract gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003408" ; a owl:Class ; rdfs:label "gland of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0003409 obo:IAO_0000115 "Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue." ; oboInOwl:hasDbXref "EMAPA:25097" ; oboInOwl:hasExactSynonym "lingual gland", "tongue gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003409" ; a owl:Class ; rdfs:label "gland of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0003412 obo:IAO_0000115 "Mesenchyme that is part of a pelvic appendage bud." ; obo:UBPROP_0000001 "Mesoderm part of pelvic fin bud.[TAO]" ; oboInOwl:hasDbXref "EHDAA2:0001035", "EMAPA:16781", "TAO:0001386", "ZFA:0001386" ; oboInOwl:hasExactSynonym "leg mesenchyme", "lower limb bud mesenchyme" ; oboInOwl:hasNarrowSynonym "hindlimb bud mesenchyme", "mesoderm pelvic fin bud", "pelvic fin bud mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003412" ; a owl:Class ; rdfs:label "pelvic appendage bud mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005730 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005420 ] ) ] . obo:UBERON_0003413 obo:IAO_0000115 "Mesenchyme that is part of a pectoral appendage bud." ; obo:UBPROP_0000001 "Mesoderm that is part of the pectoral fin bud.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0005703" ; oboInOwl:hasDbXref "EHDAA2:0002135", "EHDAA:1703", "EMAPA:16408", "TAO:0000789", "ZFA:0000789" ; oboInOwl:hasNarrowSynonym "arm mesenchyme", "forelimb bud mesenchyme", "mesoderm pectoral fin bud", "pectoral fin bud mesenchyme", "upper limb bud mesenchyme", "wing mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003413" ; a owl:Class ; rdfs:label "pectoral appendage bud mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005419 ] ) ] . obo:UBERON_0003414 obo:IAO_0000115 "Mesenchyme that is part of a developing mandible [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17912" ; oboInOwl:hasExactSynonym "bone of lower jaw mesenchyme", "bone of ventral mandibular arch mesenchyme", "bone organ of lower jaw mesenchyme", "bone organ of ventral mandibular arch mesenchyme", "lower jaw bone mesenchyme", "lower jaw bone organ mesenchyme", "mandible mesenchyme", "mandibulla mesenchyme", "mesenchyme of bone of lower jaw", "mesenchyme of bone of ventral mandibular arch", "mesenchyme of bone organ of lower jaw", "mesenchyme of bone organ of ventral mandibular arch", "mesenchyme of lower jaw bone", "mesenchyme of lower jaw bone organ", "mesenchyme of mandibulla", "mesenchyme of ventral mandibular arch bone", "mesenchyme of ventral mandibular arch bone organ", "ventral mandibular arch bone mesenchyme", "ventral mandibular arch bone organ mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003414" ; a owl:Class ; rdfs:label "mesenchyme of mandible" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ] ) ] . obo:UBERON_0003415 obo:IAO_0000115 "Mesenchyme that is part of a developing nasal septum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18443", "FMA:312700" ; oboInOwl:hasExactSynonym "nasal septum mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003415" ; a owl:Class ; rdfs:label "mesenchyme of nasal septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001706 ] ) ] . obo:UBERON_0003416 obo:IAO_0000115 "Mesenchyme that is part of a developing tongue [Automatically generated definition]." ; obo:IAO_0000116 "TODO - develops_from" ; oboInOwl:hasDbXref "EHDAA2:0004614", "EMAPA:17882" ; oboInOwl:hasExactSynonym "tongue mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003416" ; a owl:Class ; rdfs:label "mesenchyme of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0003417 obo:IAO_0000115 "Mesenchyme that is part of a developing soft palate [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18951" ; oboInOwl:hasExactSynonym "soft palate mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003417" ; a owl:Class ; rdfs:label "mesenchyme of soft palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid127284 ) ] . obo:UBERON_0003418 obo:IAO_0000115 "Mesenchyme that is part of a developing submandibular gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18814", "VHOG:0001110" ; oboInOwl:hasExactSynonym "submandibular gland mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submaxillary gland mesenchyme" ; oboInOwl:id "UBERON:0003418" ; a owl:Class ; rdfs:label "mesenchyme of submandibular gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001736 ] ) ] . obo:UBERON_0003419 obo:IAO_0000115 "Mesenchyme that is part of a developing parotid gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18539", "VHOG:0001435" ; oboInOwl:hasExactSynonym "mesenchyme of parotid gland", "parotid gland mesenchyme", "parotid mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003419" ; a owl:Class ; rdfs:label "mesenchyme of parotid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0003420 obo:IAO_0000115 "Mesenchyme that is part of a developing sublingual gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18811", "VHOG:0001106" ; oboInOwl:hasExactSynonym "Rivinus'gland mesenchyme", "ductus sublingualis mesenchyme", "mesenchyme of Rivinus'gland", "mesenchyme of ductus sublingualis", "sublingual gland mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003420" ; a owl:Class ; rdfs:label "mesenchyme of sublingual gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001832 ] ) ] . obo:UBERON_0003422 obo:IAO_0000115 "A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP]." ; obo:IAO_0000116 "TODO - check" ; oboInOwl:hasDbXref "EMAPA:26127", "EMAPA:35925", "SCTID:368069009", "Wikipedia:Wharton's_jelly" ; oboInOwl:hasExactSynonym "Wharton's jelly", "umbilical cord mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003422" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesenchyme of umbilical cord" ; rdfs:subClassOf _:genid128379 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:UBERON_0003424 obo:IAO_0000115 "Mesenchyme that is part of a developing hard palate [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18954" ; oboInOwl:hasExactSynonym "hard palate mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003424" ; a owl:Class ; rdfs:label "mesenchyme of hard palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003216 ] ) ] . obo:UBERON_0003425 obo:IAO_0000115 "A lymph node that is located in a kidney [Automatically generated definition]." ; obo:UBPROP_0000001 "Dorsal to the ipsilateral kidney nearby the renal blood vessels, caudal to the adrenal gland" ; oboInOwl:hasDbXref "FMA:276799", "MA:0002882", "NCIT:C77646", "UMLS:C2699031" ; oboInOwl:hasExactSynonym "kidney lymph node", "lymph node of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003425" ; a owl:Class ; rdfs:label "renal lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0003426 obo:IAO_0000115 "An adipose tissue that is part of a dermis [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000798" ; oboInOwl:hasExactSynonym "adipose tissue of dermis", "dermis fat tissue", "dermis fatty tissue", "fat tissue of dermis", "fatty tissue of dermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003426" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dermis adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:UBERON_0003427 obo:IAO_0000115 "The encapsulated adipose tissue in the abdomen." ; oboInOwl:hasDbXref "EMAPA:36499", "MA:0000472" ; oboInOwl:hasExactSynonym "abdomen fat pad", "abdominal fat depot", "fat pad of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003427" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "abdominal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003428 obo:IAO_0000115 "The encapsulated adipose tissue associated with the ovaries or testes." ; obo:IAO_0000116 "consider change relationship from part_of" ; obo:UBPROP_0000001 "Anatomical structure associated with the gonads which vary in form among amphibians but are primarily composed of adipose tissue and are thought to be a source of nutrients for the gonads.[AAO]" ; obo:UBPROP_0000012 "we place the amphibian structures here as their definitions state a gonadal association." ; oboInOwl:hasDbXref "AAO:0000157", "EFO:0000811", "MA:0002547", "XAO:0003050" ; oboInOwl:hasExactSynonym "fat pad of gonad", "fat pad of gonads", "gonad fat pad", "gonad-associated fat pad", "gonadal fat depot", "gonadal fat pad" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003428" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "gonadal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000991 ] ) ] . obo:UBERON_0003429 obo:IAO_0000115 "A nerve that is part of an abdomen [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000521" ; oboInOwl:hasExactSynonym "nerve of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003429" ; a owl:Class ; rdfs:label "abdomen nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003430 obo:IAO_0000115 "A nerve that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37263", "MA:0000588" ; oboInOwl:hasExactSynonym "neck (volume) nerve", "nerve of neck", "nerve of neck (volume)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003430" ; a owl:Class ; rdfs:label "neck nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0003431 obo:IAO_0000115 "A nerve that is part of a leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37343", "MA:0000673" ; oboInOwl:hasExactSynonym "nerve of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003431" ; a owl:Class ; rdfs:label "leg nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0003432 obo:IAO_0000115 "A nerve that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37266", "MA:0000551" ; oboInOwl:hasExactSynonym "anterior thoracic region nerve", "anterolateral part of thorax nerve", "front of thorax nerve", "nerve of anterior thoracic region", "nerve of anterolateral part of thorax", "nerve of chest", "nerve of front of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003432" ; a owl:Class ; rdfs:label "chest nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0003433 obo:IAO_0000115 "A nerve that is part of an arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37336", "MA:0000595" ; oboInOwl:hasExactSynonym "brachial region nerve", "nerve of arm", "nerve of brachial region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003433" ; a owl:Class ; rdfs:label "arm nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 _:genid127400 ) ] . obo:UBERON_0003434 obo:IAO_0000115 "A nerve that is part of a wrist [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37339", "MA:0000637" ; oboInOwl:hasExactSynonym "carpal region nerve", "nerve of carpal region", "nerve of wrist" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003434" ; a owl:Class ; rdfs:label "wrist nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] . obo:UBERON_0003435 obo:IAO_0000115 "A nerve that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37348", "MA:0000649", "SCTID:300056004" ; oboInOwl:hasExactSynonym "digit of foot nerve", "digit of terminal segment of free lower limb nerve", "digitus pedis nerve", "foot digit nerve", "hind limb digit nerve", "nerve of digit of foot", "nerve of digit of terminal segment of free lower limb", "nerve of digitus pedis", "nerve of foot digit", "nerve of terminal segment of free lower limb digit", "nerve of toe", "terminal segment of free lower limb digit nerve", "toe nerve" ; oboInOwl:hasNarrowSynonym "foot digit nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003435" ; a owl:Class ; rdfs:label "pedal digit nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003436 obo:IAO_0000115 "A nerve that is part of a shoulder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37335", "MA:0000634" ; oboInOwl:hasExactSynonym "nerve of shoulder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003436" ; a owl:Class ; rdfs:label "shoulder nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0003437 obo:IAO_0000115 "A nerve that innervates an eyelid." ; oboInOwl:hasDbXref "EMAPA:37535", "MA:0001255" ; oboInOwl:hasExactSynonym "blepharon nerve", "nerve of blepharon", "nerve of eyelid", "palpebral nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003437" ; a owl:Class ; rdfs:label "eyelid nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0003438 obo:IAO_0000115 "Any nerve that innervates the iris." ; obo:IAO_0000116 "added for consistency with mouse ontologies. The term 'ciliary nerve' is usually used to denote either of the two nerves (with different origins) that innervate the iris, as well as ciliary muscles and cornea" ; oboInOwl:hasDbXref "EMAPA:35449", "MA:0001291" ; oboInOwl:hasExactSynonym "nerve of iris" ; oboInOwl:hasNarrowSynonym "ciliary nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003438" ; a owl:Class ; rdfs:label "iris nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] . obo:UBERON_0003439 obo:IAO_0000115 "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." ; oboInOwl:hasDbXref "EMAPA:37264", "MA:0000515" ; oboInOwl:hasExactSynonym "nerve of torso", "nerve of trunk", "torso nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trunk nerve" ; oboInOwl:id "UBERON:0003439" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:label "nerve of trunk region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0003440 obo:IAO_0000115 "A nerve that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37291", "MA:0000693", "SCTID:359923002" ; oboInOwl:hasExactSynonym "nerve of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003440" ; a owl:Class ; rdfs:label "limb nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003441 obo:IAO_0000115 "A nerve that is part of a forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37334", "MA:0000616" ; oboInOwl:hasExactSynonym "fore limb nerve", "nerve of fore limb", "nerve of forelimb", "nerve of superior member", "nerve of upper extremity" ; oboInOwl:hasNarrowSynonym "wing nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003441" ; a owl:Class ; rdfs:label "forelimb nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003442 obo:IAO_0000115 "A nerve that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37342", "MA:0000664" ; oboInOwl:hasExactSynonym "hind limb nerve", "nerve of hind limb", "nerve of hindlimb", "nerve of inferior member", "nerve of lower extremity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003442" ; a owl:Class ; rdfs:label "hindlimb nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003443 obo:IAO_0000115 "A nerve that is located in a thoracic cavity [Automatically generated definition]." ; obo:IAO_0000116 "consider merging with thoracic nerve. In MA the only subclass is the phrenic nerve, which arises from a cervical nerve" ; oboInOwl:hasDbXref "EMAPA:37267", "MA:0000556" ; oboInOwl:hasExactSynonym "cavity of chest nerve", "cavity of thorax nerve", "chest cavity nerve", "nerve of cavity of chest", "nerve of cavity of thorax", "nerve of chest cavity", "nerve of pectoral cavity", "nerve of thoracic cavity", "pectoral cavity nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003443" ; a owl:Class ; rdfs:label "thoracic cavity nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0003444 obo:IAO_0000115 "A nerve that is part of a pelvis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37269", "MA:0000542" ; oboInOwl:hasExactSynonym "nerve of pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003444" ; a owl:Class ; rdfs:label "pelvis nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0003445 obo:IAO_0000115 "A nerve that is part of a foot [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37347", "MA:0000653" ; oboInOwl:hasExactSynonym "foot nerve", "nerve of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003445" ; a owl:Class ; rdfs:label "pes nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 _:genid127523 ) ] . obo:UBERON_0003446 obo:IAO_0000115 "A nerve that is part of an ankle [Automatically generated definition]." ; obo:UBPROP_0000012 "FMA placement dubious" ; oboInOwl:hasDbXref "EMAPA:37346", "MA:0000640" ; oboInOwl:hasExactSynonym "nerve of ankle", "tarsal region nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural network of ankle" ; oboInOwl:id "UBERON:0003446" ; a owl:Class ; rdfs:label "ankle nerve" ; rdfs:seeAlso obo:FMA_86901 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] . obo:UBERON_0003447 obo:IAO_0000115 "A nerve that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37341", "MA:0000625", "SCTID:181015006" ; oboInOwl:hasExactSynonym "digit of hand nerve", "digit of terminal segment of free upper limb nerve", "digitus manus nerve", "finger nerve", "hand digit nerve", "nerve of digit of hand", "nerve of digit of terminal segment of free upper limb", "nerve of digitus manus", "nerve of finger", "nerve of hand digit", "nerve of terminal segment of free upper limb digit", "terminal segment of free upper limb digit nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003447" ; a owl:Class ; rdfs:label "digit nerve of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 _:genid127541 ) ] . obo:UBERON_0003448 obo:IAO_0000115 "A nerve that is part of a manus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37340", "MA:0000629" ; oboInOwl:hasExactSynonym "hand nerve", "nerve of hand", "nerve of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003448" ; a owl:Class ; rdfs:label "manus nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0003449 obo:IAO_0000115 "An intervertebral disk that is part of a tail [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19592", "MA:0000698" ; oboInOwl:hasExactSynonym "intervertebral disc of post-ventral region", "intervertebral disc of tail", "intervertebral disk of post-ventral region", "intervertebral disk of tail", "tail intervertebral disk", "tail spinal disc" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003449" ; a owl:Class ; rdfs:label "tail intervertebral disc" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0003450 obo:IAO_0000115 "An incisor tooth that is part of a upper jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002121", "EMAPA:17939", "FMA:321754", "MA:0001601", "NCIT:C49794", "SCTID:421578001", "UMLS:C1710579" ; oboInOwl:hasExactSynonym "incisor of palatoquadrate arch", "incisor of upper jaw", "incisor tooth of palatoquadrate arch", "incisor tooth of upper jaw", "palatoquadrate arch incisor", "palatoquadrate arch incisor tooth", "upper incisor", "upper jaw incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillary incisor tooth", "premaxillary tooth" ; oboInOwl:id "UBERON:0003450" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper jaw incisor" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002244 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0003451 obo:IAO_0000115 "An incisor tooth that is part of a lower jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001942", "EHDAA2:0001021", "EMAPA:17918", "MA:0001600", "NCIT:C49583", "UMLS:C1708755" ; oboInOwl:hasExactSynonym "incisor of lower jaw", "incisor of ventral mandibular arch", "incisor tooth of lower jaw", "incisor tooth of ventral mandibular arch", "lower incisor", "lower jaw incisor tooth", "mandibular incisor", "ventral mandibular arch incisor", "ventral mandibular arch incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003451" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower jaw incisor" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003456 obo:IAO_0000115 "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37580", "MA:0001824" ; oboInOwl:hasExactSynonym "apparatus respiratorius lymph vessel", "apparatus respiratorius lymphatic vessel", "lymph vessel of apparatus respiratorius", "lymph vessel of respiratory system", "lymphatic vessel of apparatus respiratorius", "lymphatic vessel of respiratory system", "respiratory system lymph vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003456" ; a owl:Class ; rdfs:label "respiratory system lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003457 obo:IAO_0000115 "A bone that is part of a head [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35996", "MA:0000576", "SCTID:118646007" ; oboInOwl:hasExactSynonym "adult head bone", "adult head bone organ", "bone of adult head", "bone of head", "bone organ of adult head", "bone organ of head", "head bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "craniofacial bone" ; oboInOwl:id "UBERON:0003457" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Different sources vary regarding which bones are craniofacial; e.g. hyoid bone" ; rdfs:label "head bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0003458 obo:IAO_0000115 "A bone that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37246", "MA:0000584" ; oboInOwl:hasExactSynonym "bone of neck", "bone of neck (volume)", "bone organ of neck", "bone organ of neck (volume)", "neck (volume) bone", "neck (volume) bone organ", "neck bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003458" ; a owl:Class ; rdfs:label "neck bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0003459 obo:IAO_0000115 "A bone that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18025", "MA:0000547" ; oboInOwl:hasExactSynonym "anterior thoracic region bone", "anterior thoracic region bone organ", "anterolateral part of thorax bone", "anterolateral part of thorax bone organ", "bone of anterior thoracic region", "bone of anterolateral part of thorax", "bone of chest", "bone of front of thorax", "bone organ of anterior thoracic region", "bone organ of anterolateral part of thorax", "bone organ of chest", "bone organ of front of thorax", "chest bone organ", "front of thorax bone", "front of thorax bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003459" ; a owl:Class ; rdfs:label "chest bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0003460 obo:IAO_0000115 "A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia." ; oboInOwl:hasDbXref "EMAPA:37303", "MA:0000592", "MESH:D050280" ; oboInOwl:hasExactSynonym "arm bone organ", "bone of arm", "bone organ of arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of upper extremity" ; oboInOwl:id "UBERON:0003460" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "arm bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0003461 obo:IAO_0000115 "A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods." ; obo:UBPROP_0000012 "this is a forelimb bone in MA, but this would lead to part-disjointness violations." ; oboInOwl:hasDbXref "MA:0000631" ; oboInOwl:hasExactSynonym "bone of shoulder", "shoulder-articulating bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003461" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "shoulder bone" ; rdfs:subClassOf obo:UBERON_0010741, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012475 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0016884 ] ) ] . obo:UBERON_0003462 obo:IAO_0000115 "A bone that is part of a facial skeleton [Automatically generated definition]." ; obo:IAO_0000116 "test whether 'facial bone' is an exact synonym" ; oboInOwl:hasDbXref "EMAPA:19019", "EMAPA:35924", "MA:0001482", "MA:0003159", "MESH:D005147", "NCIT:C63706", "SCTID:181799005", "UMLS:C0015455" ; oboInOwl:hasExactSynonym "bone of facial skeleton", "facial bone", "facial skeleton bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of viscerocranium", "viscerocranium bone" ; oboInOwl:id "UBERON:0003462" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "facial bone" ; rdfs:subClassOf _:genid128756 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ] ) ] . obo:UBERON_0003463 obo:IAO_0000115 "A bone that is part of a trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36583", "MA:0000512", "SCTID:427358002" ; oboInOwl:hasExactSynonym "bone of torso", "bone of trunk", "bone organ of torso", "bone organ of trunk", "torso bone", "torso bone organ", "trunk bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003463" ; a owl:Class ; rdfs:label "trunk bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0003464 obo:IAO_0000115 "A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle)." ; obo:UBPROP_0000012 "the MA class is actually bone of pelvic complex; in contrast the NCIT class excludes ilium etc" ; oboInOwl:hasDbXref "EFO:0003842", "GAID:198", "NCIT:C12982", "SCTID:361370006", "UMLS:C0448188" ; oboInOwl:hasExactSynonym "bone of hind limb", "bone of hindlimb", "bone of inferior member", "bone of lower extremity", "bone organ of hind limb", "bone organ of hindlimb", "bone organ of lower extremity", "hind limb bone", "hind limb bone organ", "hindlimb bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003464" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "hindlimb bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010885 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003466 obo:IAO_0000115 "A bone that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35347", "MA:0000598" ; oboInOwl:hasExactSynonym "antebrachial region bone", "antebrachial region bone organ", "arm zeugopod bone", "arm zeugopod bone organ", "lower arm bone", "zeugopod bone, forelimb", "zeugopod bone, upper" ; oboInOwl:hasNarrowSynonym "wing zeugopod bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003466" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "forelimb zeugopod bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0003468 obo:IAO_0000115 "The ureteral branches of renal artery are small branches which supply the ureter." ; oboInOwl:hasBroadSynonym "ureteric artery" ; oboInOwl:hasDbXref "EMAPA:37676", "FMA:70491", "MA:0002074", "SCTID:65376008", "Wikipedia:Ureteral_branches_of_renal_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003468" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ureteric segment of renal artery" ; rdfs:subClassOf _:genid128814, _:genid128816 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0003469 obo:IAO_0000115 "An artery that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37569", "MA:0001804" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003469" ; a owl:Class ; rdfs:label "respiratory system artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003470 obo:IAO_0000115 "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." ; oboInOwl:hasDbXref "EMAPA:37430", "FMA:49570", "MA:0001917", "SCTID:145137009", "Wikipedia:Superior_labial_artery" ; oboInOwl:hasExactSynonym "arteria labialis superior", "ramus labialis superior arteriae facialis", "superior labial artery", "superior labial branch of facial artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003470" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "artery of upper lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid128832 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0003471 obo:IAO_0000115 "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." ; oboInOwl:hasDbXref "EMAPA:37429", "FMA:49567", "MA:0001916", "SCTID:145036002", "Wikipedia:Inferior_labial_artery" ; oboInOwl:hasExactSynonym "arteria labialis inferior", "inferior labial artery", "inferior labial branch of facial artery", "ramus labialis inferior (arteria facialis)", "ramus labialis inferior arteriae facialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003471" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "artery of lower lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid128845 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] . obo:UBERON_0003472 obo:IAO_0000115 "An artery that supplies blood to the cerebellum." ; oboInOwl:hasDbXref "EHDAA2:0000228", "EHDAA:5290", "EMAPA:37074", "MA:0001933", "NCIT:C52845", "SCTID:278102002", "UMLS:C0226246", "Wikipedia:Cerebellar_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003472" ; a owl:Class ; rdfs:label "cerebellar artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/CerebellumArteries.jpg"^^xsd:anyURI . obo:UBERON_0003473 obo:IAO_0000115 "An artery that is part of a thoracic cavity[cjm]." ; obo:UBPROP_0000012 "in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity" ; oboInOwl:hasDbXref "EMAPA:37241", "MA:0001902", "MESH:D013895" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thoracic artery" ; oboInOwl:id "UBERON:0003473" ; a owl:Class ; rdfs:label "thoracic cavity artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0003474 obo:IAO_0000115 "One of the arteries supplying a meninix[Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37104", "GAID:499", "MA:0002001", "MESH:D008576", "Wikipedia:Meningeal_arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003474" ; a owl:Class ; rdfs:label "meningeal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002360 ] ) ] . obo:UBERON_0003475 obo:IAO_0000115 "A vein that is part of a ureter [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37679", "MA:0002250" ; oboInOwl:hasExactSynonym "ureter vein", "vein of ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003475" ; a owl:Class ; rdfs:label "ureteric vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0003476 obo:IAO_0000115 "A vein that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37584", "MA:0001809", "MA:0001810" ; oboInOwl:hasExactSynonym "apparatus respiratorius vein", "respiratory system vein", "vein of apparatus respiratorius", "vein of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003476" ; a owl:Class ; rdfs:label "respiratory system venous blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003477 obo:IAO_0000115 "The inferior labial vein is the vein receiving blood from the upper lip." ; oboInOwl:hasDbXref "EMAPA:37204", "FMA:52538", "MA:0002255", "SCTID:422755007", "Wikipedia:Superior_labial_vein" ; oboInOwl:hasExactSynonym "superior labial vein", "upper lip vein", "vena labialis superior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003477" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vein of upper lip" ; rdfs:subClassOf _:genid128898 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0003478 obo:IAO_0000115 "The inferior labial vein is the vein receiving blood from the lower lip." ; oboInOwl:hasDbXref "EMAPA:37202", "FMA:52541", "MA:0002253", "SCTID:422955002", "Wikipedia:Inferior_labial_vein" ; oboInOwl:hasExactSynonym "inferior labial vein", "lower lip vein", "vena labialis inferior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae labiales inferiores" ; oboInOwl:id "UBERON:0003478" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vein of lower lip" ; rdfs:subClassOf _:genid128909 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png"^^xsd:anyURI . obo:UBERON_0003479 obo:IAO_0000115 "A vein that is part of a thoracic cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37242", "MA:0001903" ; oboInOwl:hasExactSynonym "cavity of chest vein", "cavity of thorax vein", "chest cavity vein", "pectoral cavity vein", "vein of cavity of chest", "vein of cavity of thorax", "vein of chest cavity", "vein of pectoral cavity", "vein of thoracic cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003479" ; a owl:Class ; rdfs:label "thoracic cavity vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0003480 obo:IAO_0000115 "A vein that is part of a clitoris [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37201", "MA:0002252", "SCTID:360819004" ; oboInOwl:hasExactSynonym "clitoris vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003480" ; a owl:Class ; rdfs:label "vein of clitoris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] . obo:UBERON_0003481 obo:IAO_0000115 "A vein that is part of a tail [Automatically generated definition]." ; obo:IAO_0000116 "see also caudal vein" ; oboInOwl:hasDbXref "AAO:0011105", "EMAPA:37761", "MA:0002233", "Wikipedia:Tail_vein", "XAO:0000393" ; oboInOwl:hasExactSynonym "post-vent region vein", "vein of post-vent region", "vein of tail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudal vein" ; oboInOwl:id "UBERON:0003481" ; a owl:Class ; rdfs:label "tail vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0003482 obo:IAO_0000115 "A portion of vein that is part of a trabecular bone tissue [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37203", "MA:0002254" ; oboInOwl:hasExactSynonym "spongy bone vein", "trabecular bone tissue vein", "trabecular bone vein", "vein of spongy bone", "vein of trabecular bone tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003482" ; a owl:Class ; rdfs:label "vein of trabecular bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002483 ] ) ] . obo:UBERON_0003483 obo:IAO_0000115 "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37766", "MA:0002673", "MESH:D013950", "NCIT:C38515", "UMLS:C1515429" ; oboInOwl:hasExactSynonym "lymphoid tissue of thymus", "lymphoid tissue of thymus gland", "thymus gland lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003483" ; a owl:Class ; rdfs:label "thymus lymphoid tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000893 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001744 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0003484 obo:IAO_0000115 "A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland." ; oboInOwl:hasDbXref "EMAPA:37531", "MA:0002452" ; oboInOwl:hasExactSynonym "camera-type eye sebaceous gland", "sebaceous gland of camera-type eye", "sebaceous gland of vertebrate eye", "vertebrate eye sebaceous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003484" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "eye sebaceous gland" ; rdfs:subClassOf obo:UBERON_0003487 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003485 obo:IAO_0000115 "A sebaceous gland that is part of a vagina [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37793", "MA:0001732" ; oboInOwl:hasExactSynonym "sebaceous gland of vagina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003485" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "vagina sebaceous gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0003487 obo:IAO_0000115 "A holocrine gland of the dermis that secretes sebum into hair follicles." ; oboInOwl:hasDbXref "MA:0000149", "SCTID:115977007" ; oboInOwl:hasExactSynonym "cutaneous sebaceous gland", "sebaceous gland of skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003487" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin sebaceous gland" ; rdfs:subClassOf obo:UBERON_0001821, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ], _:genid128990 . obo:UBERON_0003488 obo:IAO_0000115 "A lactiferous gland that is part of the abdominal region [Automatically generated definition]." ; obo:UBPROP_0000008 "Female mice normally have five pairs of nipples and mammary glands, three in the thoracic and two in the abdominal region. (There is an additional abdominal pair in female rats.) http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" ; oboInOwl:hasDbXref "EMAPA:36507", "MA:0000787", "SCTID:113191002", "SCTID:68037003" ; oboInOwl:hasExactSynonym "abdomen lactiferous gland", "abdomen lobe of breast", "abdomen lobe of mammary gland", "abdomen mammary gland", "lactiferous gland of abdomen", "lobe of breast of abdomen", "lobe of mammary gland of abdomen", "mammary gland of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003488" ; a owl:Class ; rdfs:label "abdominal mammary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003489 obo:IAO_0000115 "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37575", "MA:0001808" ; oboInOwl:hasExactSynonym "apparatus respiratorius blood capillary endothelium", "apparatus respiratorius capillary endothelium", "apparatus respiratorius capillary vessel endothelium", "apparatus respiratorius endothelium of blood capillary", "apparatus respiratorius endothelium of capillary", "apparatus respiratorius endothelium of capillary vessel", "blood capillary endothelium of apparatus respiratorius", "blood capillary endothelium of respiratory system", "capillary endothelium of apparatus respiratorius", "capillary endothelium of respiratory system", "capillary vessel endothelium of apparatus respiratorius", "capillary vessel endothelium of respiratory system", "endothelium of blood capillary of apparatus respiratorius", "endothelium of blood capillary of respiratory system", "endothelium of capillary of apparatus respiratorius", "endothelium of capillary of respiratory system", "endothelium of capillary vessel of apparatus respiratorius", "endothelium of capillary vessel of respiratory system", "respiratory system blood capillary endothelium", "respiratory system capillary vessel endothelium", "respiratory system endothelium of blood capillary", "respiratory system endothelium of capillary", "respiratory system endothelium of capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003489" ; a owl:Class ; rdfs:label "respiratory system capillary endothelium" ; rdfs:subClassOf _:genid129011, _:genid129013 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003494 obo:IAO_0000115 "A venule that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37587", "MA:0001813" ; oboInOwl:hasExactSynonym "apparatus respiratorius venule", "venule of apparatus respiratorius", "venule of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003494" ; a owl:Class ; rdfs:label "respiratory system venule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003495 obo:IAO_0000115 "An arteriole that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37568", "MA:0001803" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003495" ; a owl:Class ; rdfs:label "respiratory system arteriole" ; rdfs:subClassOf _:genid129053 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003496 obo:IAO_0000115 "A blood vessel that is part of a head [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36610", "MA:0000575", "SCTID:127865000" ; oboInOwl:hasExactSynonym "adult head blood vessel", "blood vessel of adult head", "blood vessel of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003496" ; a owl:Class ; rdfs:label "head blood vessel" ; rdfs:subClassOf _:genid129061 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0003497 obo:IAO_0000115 "A blood vessel that is part of an abdomen [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000518" ; oboInOwl:hasExactSynonym "blood vessel of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003497" ; a owl:Class ; rdfs:label "abdomen blood vessel" ; rdfs:seeAlso "UBERON:0012254" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003498 obo:IAO_0000115 "A blood vessel that is part of a heart [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35397", "MA:0002483" ; oboInOwl:hasExactSynonym "blood vessel of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac blood vessel" ; oboInOwl:id "UBERON:0003498" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "heart blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0018674 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0003499 obo:IAO_0000115 "A blood vessel that is part of a brain [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35182", "MA:0002769" ; oboInOwl:hasExactSynonym "blood vessel of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003499" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008998 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0003500 obo:IAO_0000115 "A blood vessel that is part of a cornea [Automatically generated definition]." ; obo:IAO_0000116 "follow up on tracker item" ; obo:RO_0002175 obo:NCBITaxon_9775 ; oboInOwl:hasDbXref "EMAPA:36611", "MA:0001241" ; oboInOwl:hasExactSynonym "blood vessel of cornea", "cornea blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003500" ; a owl:Class ; rdfs:label "corneal blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ] ) ] . obo:UBERON_0003501 obo:IAO_0000115 "A blood vessel that is part of a retina [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36520", "GAID:509", "MA:0001317", "MESH:D012171", "SCTID:280692003", "XAO:0004153" ; oboInOwl:hasExactSynonym "blood vessel of inner layer of eyeball", "blood vessel of retina", "blood vessel of tunica interna of eyeball", "inner layer of eyeball blood vessel", "retinal blood vessel", "tunica interna of eyeball blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003501" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "retina blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004864 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000966 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:UBERON_0003502 obo:IAO_0000115 "A blood vessel that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37236", "MA:0000583" ; oboInOwl:hasExactSynonym "blood vessel of neck", "blood vessel of neck (volume)", "neck (volume) blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003502" ; a owl:Class ; rdfs:label "neck blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0003503 obo:IAO_0000115 "A blood vessel that is part of a leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36500", "MA:0000669" ; oboInOwl:hasExactSynonym "blood vessel of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003503" ; a owl:Class ; rdfs:label "leg blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid128045 ] . obo:UBERON_0003504 obo:IAO_0000115 "A blood vessel that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35731", "EMAPA:35995", "MA:0001799" ; oboInOwl:hasExactSynonym "apparatus respiratorius blood vessel", "blood vessel of apparatus respiratorius", "blood vessel of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003504" ; a owl:Class ; rdfs:label "respiratory system blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003505 obo:IAO_0000115 "A blood vessel that is part of a trachea." ; oboInOwl:hasAlternativeId "UBERON:0003525" ; oboInOwl:hasDbXref "EMAPA:35874", "MA:0001852" ; oboInOwl:hasExactSynonym "blood vessel of trachea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003505" ; a owl:Class ; rdfs:label "trachea blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0003506 obo:IAO_0000115 "A blood vessel that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37239", "MA:0000549" ; oboInOwl:hasExactSynonym "anterior thoracic region blood vessel", "anterolateral part of thorax blood vessel", "blood vessel of anterior thoracic region", "blood vessel of anterolateral part of thorax", "blood vessel of chest", "blood vessel of front of thorax", "front of thorax blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003506" ; a owl:Class ; rdfs:label "chest blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0003507 obo:IAO_0000115 "A blood vessel that is part of an arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37293", "MA:0000591" ; oboInOwl:hasExactSynonym "blood vessel of arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003507" ; a owl:Class ; rdfs:label "arm blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0003508 obo:IAO_0000115 "A blood vessel that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37302", "MA:0000645" ; oboInOwl:hasExactSynonym "blood vessel of digit of foot", "blood vessel of digit of terminal segment of free lower limb", "blood vessel of digitus pedis", "blood vessel of foot digit", "blood vessel of terminal segment of free lower limb digit", "blood vessel of toe", "digit of foot blood vessel", "digit of terminal segment of free lower limb blood vessel", "digitus pedis blood vessel", "foot digit blood vessel", "hind limb digit blood vessel", "terminal segment of free lower limb digit blood vessel", "toe blood vessel" ; oboInOwl:hasNarrowSynonym "foot digit blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003508" ; a owl:Class ; rdfs:label "pedal digit blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003509 obo:IAO_0000115 "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." ; oboInOwl:hasDbXref "EMAPA:35144", "MA:0000061" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003509" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "only in MA - supertype of artery, arteriole, aorta." ; rdfs:label "arterial blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004572 ] ) ] . obo:UBERON_0003510 obo:IAO_0000115 "A blood vessel that is part of a eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37388", "MA:0001250" ; oboInOwl:hasExactSynonym "blepharon blood vessel", "blood vessel of blepharon", "blood vessel of eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003510" ; a owl:Class ; rdfs:label "eyelid blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0003511 obo:IAO_0000115 "A blood vessel that is part of a iris [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37387", "MA:0001290", "ZFA:0005568" ; oboInOwl:hasExactSynonym "blood vessel of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003511" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "iris blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004118 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] . obo:UBERON_0003512 obo:IAO_0000115 "A blood vessel that is part of a lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32867", "MA:0002457" ; oboInOwl:hasExactSynonym "blood vessel of lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pulmonary vascular element" ; oboInOwl:id "UBERON:0003512" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lung blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0003513 obo:IAO_0000115 "A blood vessel that is part of a trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37237", "MA:0000511" ; oboInOwl:hasExactSynonym "blood vessel of torso", "blood vessel of trunk", "torso blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003513" ; a owl:Class ; rdfs:label "trunk blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0003514 obo:IAO_0000115 "A blood vessel that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36598", "MA:0000687" ; oboInOwl:hasExactSynonym "blood vessel of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003514" ; a owl:Class ; rdfs:label "limb blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003515 obo:IAO_0000115 "A blood vessel that is part of a forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37292", "MA:0000611" ; oboInOwl:hasExactSynonym "anteriormost limb blood vessel", "blood vessel of anteriormost limb", "blood vessel of fore limb", "blood vessel of forelimb", "blood vessel of upper extremity", "fore limb blood vessel" ; oboInOwl:hasNarrowSynonym "wing blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003515" ; a owl:Class ; rdfs:label "forelimb blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003516 obo:IAO_0000115 "A blood vessel that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37298", "MA:0000659" ; oboInOwl:hasExactSynonym "blood vessel of hind limb", "blood vessel of hindlimb", "blood vessel of lower extremity", "hind limb blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003516" ; a owl:Class ; rdfs:label "hindlimb blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003517 obo:IAO_0000115 "A blood vessel that is part of a kidney [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:28457", "MA:0001682", "TAO:0005306", "ZFA:0005306" ; oboInOwl:hasExactSynonym "blood vessel of kidney", "renal blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003517" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "kidney blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0003519 obo:IAO_0000115 "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37240", "MA:0000554" ; oboInOwl:hasExactSynonym "blood vessel of cavity of chest", "blood vessel of cavity of thorax", "blood vessel of chest cavity", "blood vessel of pectoral cavity", "blood vessel of thoracic cavity", "cavity of chest blood vessel", "cavity of thorax blood vessel", "chest cavity blood vessel", "pectoral cavity blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003519" ; a owl:Class ; rdfs:label "thoracic cavity blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0003520 obo:IAO_0000115 "A blood vessel that is part of a pelvis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37244", "MA:0000531" ; oboInOwl:hasExactSynonym "blood vessel of pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003520" ; a owl:Class ; rdfs:label "pelvis blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0003521 obo:IAO_0000115 "A blood vessel that is part of a foot [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37301", "MA:0000642" ; oboInOwl:hasExactSynonym "blood vessel of foot", "foot blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003521" ; a owl:Class ; rdfs:label "pes blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0003522 obo:IAO_0000115 "A blood vessel that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37297", "MA:0000621" ; oboInOwl:hasExactSynonym "blood vessel of digit of terminal segment of free upper limb", "blood vessel of terminal segment of free upper limb digit", "digit of terminal segment of free upper limb blood vessel", "finger blood vessel", "hand digit blood vessel", "terminal segment of free upper limb digit blood vessel" ; oboInOwl:hasNarrowSynonym "hand digit blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003522" ; a owl:Class ; rdfs:label "manual digit blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003523 obo:IAO_0000115 "A blood vessel that is part of a manus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37296", "MA:0000618" ; oboInOwl:hasExactSynonym "blood vessel of hand", "blood vessel of manus", "hand blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003523" ; a owl:Class ; rdfs:label "manus blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0003524 obo:IAO_0000115 "A blood vessel that is part of a tail [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35848", "MA:0000695" ; oboInOwl:hasExactSynonym "blood vessel of post-vent region", "blood vessel of tail", "post-vent region blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003524" ; a owl:Class ; rdfs:label "tail blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0003526 obo:IAO_0000115 "A capillary that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37574", "MA:0001807" ; oboInOwl:hasExactSynonym "apparatus respiratorius blood capillary", "apparatus respiratorius capillary", "apparatus respiratorius capillary vessel", "blood capillary of apparatus respiratorius", "blood capillary of respiratory system", "capillary of apparatus respiratorius", "capillary of respiratory system", "capillary vessel of apparatus respiratorius", "capillary vessel of respiratory system", "respiratory system blood capillary", "respiratory system capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003526" ; a owl:Class ; rdfs:label "respiratory system capillary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003527 obo:IAO_0000115 "A capillary that is part of a kidney [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:31443", "MA:0002586", "SCTID:275409003" ; oboInOwl:hasExactSynonym "blood capillary of kidney", "capillary of kidney", "capillary vessel of kidney", "kidney blood capillary", "kidney capillary vessel", "renal capillary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003527" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "kidney capillary" ; rdfs:subClassOf _:genid129336 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0003528 obo:IAO_0000115 "A gray matter that is part of a brain [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35184", "MA:0000810", "NCIT:C49333", "UMLS:C1707348" ; oboInOwl:hasExactSynonym "brain grey matter", "brain grey substance", "gray matter of brain", "grey matter of brain", "grey substance of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003528" ; a owl:Class ; rdfs:label "brain gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0003529 obo:IAO_0000115 "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37581", "MA:0001825" ; oboInOwl:hasExactSynonym "apparatus respiratorius endothelium of lymph vessel", "apparatus respiratorius lymph vessel endothelium", "apparatus respiratorius lymphatic vessel endothelium", "endothelium of lymph vessel of apparatus respiratorius", "endothelium of lymph vessel of respiratory system", "lymph vessel endothelium of apparatus respiratorius", "lymph vessel endothelium of respiratory system", "lymphatic vessel endothelium of apparatus respiratorius", "lymphatic vessel endothelium of respiratory system", "respiratory system endothelium of lymph vessel", "respiratory system lymph vessel endothelium", "respiratory system lymphatic vessel endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003529" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory system lymphatic vessel endothelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003530 obo:IAO_0000115 "A zone of skin that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32942", "FMA:37852", "MA:0000650", "NCIT:C52719", "SCTID:181530005", "UMLS:C1708089" ; oboInOwl:hasExactSynonym "digit of foot skin", "digit of terminal segment of free lower limb skin", "digitus pedis skin", "foot digit skin", "hind limb digit skin", "skin of digit of foot", "skin of digit of terminal segment of free lower limb", "skin of digitus pedis", "skin of foot digit", "skin of terminal segment of free lower limb digit", "skin of toe", "terminal segment of free lower limb digit skin", "toe skin" ; oboInOwl:hasNarrowSynonym "foot digit skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003530" ; a owl:Class ; rdfs:label "pedal digit skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003531 obo:IAO_0000115 "A zone of skin that is part of a forelimb [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check free limb vs pectoral complex" ; oboInOwl:hasDbXref "EMAPA:32612", "FMA:23101", "MA:0000617", "NCIT:C12296", "SCTID:244130001", "UMLS:C0222212" ; oboInOwl:hasExactSynonym "anteriormost limb skin", "fore limb skin", "skin of fore limb", "skin of forelimb", "skin of upper limb", "upper limb skin" ; oboInOwl:hasNarrowSynonym "wing skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003531" ; a owl:Class ; rdfs:label "forelimb skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003532 obo:IAO_0000115 "A zone of skin that is part of a hindlimb [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check free limb vs pelvic complex" ; oboInOwl:hasDbXref "EMAPA:32620", "FMA:23102", "MA:0000665", "NCIT:C12297", "SCTID:181528008", "UMLS:C0222268" ; oboInOwl:hasExactSynonym "hind limb skin", "lower limb skin", "skin of hind limb", "skin of hindlimb", "skin of lower extremity", "skin of lower limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003532" ; a owl:Class ; rdfs:label "hindlimb skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003533 obo:IAO_0000115 "A zone of skin that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32648", "FMA:38304", "MA:0000626", "NCIT:C52720", "SCTID:361711001", "UMLS:C1708318" ; oboInOwl:hasExactSynonym "digit of hand skin", "digit of terminal segment of free upper limb skin", "digitus manus skin", "finger skin", "fore limb digit skin", "hand digit skin", "skin of digit of hand", "skin of digit of terminal segment of free upper limb", "skin of digitus manus", "skin of finger", "skin of hand digit", "skin of terminal segment of free upper limb digit", "terminal segment of free upper limb digit skin" ; oboInOwl:hasNarrowSynonym "hand digit skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003533" ; a owl:Class ; rdfs:label "manual digit skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003534 obo:IAO_0000115 "A zone of skin that is part of a tail [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36502", "MA:0000700", "SCTID:67214004" ; oboInOwl:hasExactSynonym "post-vent region skin", "skin of post-vent region", "skin of tail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003534" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tail skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0003535 obo:IAO_0000115 "A nerve trunk that is part of a vagus nerve." ; oboInOwl:hasAlternativeId "UBERON:0006308" ; oboInOwl:hasDbXref "EHDAA2:0002160", "EHDAA:4659", "EMAPA:17272", "FMA:6221", "MA:0001150", "SCTID:280308004", "VHOG:0000736" ; oboInOwl:hasExactSynonym "trunk of vagal nerve", "trunk of vagus nerve", "vagal X nerve trunk", "vagal nerve trunk", "vagus nerve trunk", "vagus neural trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003535" ; a owl:Class ; rdfs:label "vagus X nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001759 ] ) ] . obo:UBERON_0003538 obo:IAO_0000115 "A bronchiole that is part of a right lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35425", "MA:0001787", "NCIT:C49279", "SCTID:200089000", "UMLS:C0225670" ; oboInOwl:hasExactSynonym "bronchiole of right lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003538" ; a owl:Class ; rdfs:label "right lung bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0003539 obo:IAO_0000115 "A bronchiole that is part of a left lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19000", "MA:0001778", "NCIT:C49252", "SCTID:200484003", "UMLS:C0225674" ; oboInOwl:hasExactSynonym "bronchiole of left lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003539" ; a owl:Class ; rdfs:label "left lung bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002186 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0003540 obo:IAO_0000115 "A terminal bronchiole that is part of a right lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36638", "MA:0001789", "NCIT:C49294", "UMLS:C1709961" ; oboInOwl:hasExactSynonym "bronchiolus terminalis of right lung", "right lung bronchiolus terminalis", "terminal bronchiole of right lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003540" ; a owl:Class ; rdfs:label "right lung terminal bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0003541 obo:IAO_0000115 "A terminal bronchiole that is part of a left lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36636", "MA:0001780", "NCIT:C49255", "UMLS:C1708675" ; oboInOwl:hasExactSynonym "bronchiolus terminalis of left lung", "left lung bronchiolus terminalis", "terminal bronchiole of left lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003541" ; a owl:Class ; rdfs:label "left lung terminal bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002187 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0003544 obo:IAO_0000115 "The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." ; oboInOwl:hasDbXref "EMAPA:35187", "HBA:9218", "MA:0000820", "NCIT:C49334", "UMLS:C1706995" ; oboInOwl:hasExactSynonym "brain white matter of neuraxis", "brain white substance", "white matter of brain", "white matter of neuraxis of brain", "white substance of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003544" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain white matter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0003547 obo:IAO_0000115 "A meninx that is part of a brain [Automatically generated definition]." ; obo:UBPROP_0000001 "Meninges that are part of the brain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "CALOHA:TS-2147", "EMAPA:32662", "EV:0100312", "MA:0000813", "SCTID:180949007", "VHOG:0000013" ; oboInOwl:hasExactSynonym "brain meninges", "meninges of brain", "meninx of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003547" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "brain meninx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002360 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0003548 obo:IAO_0000115 "A meninx that is part of a forebrain [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17764", "EMAPA:17774", "EMAPA:37543", "MA:0000883" ; oboInOwl:hasExactSynonym "forebrain meninx", "meninges of forebrain", "meninx of forebrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003548" ; a owl:Class ; rdfs:label "forebrain meninges" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002360 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0003549 obo:IAO_0000115 "The fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule." ; obo:UBPROP_0000001 "The innermost of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:32667", "EV:0100315", "MA:0000816", "NCIT:C49335", "UMLS:C1706994", "VHOG:0000470" ; oboInOwl:hasExactSynonym "brain pia mater of neuraxis", "pia mater of brain", "pia mater of neuraxis of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003549" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0003550 obo:IAO_0000115 "A pia mater that is part of a forebrain [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17767", "EMAPA:17777", "EMAPA:37546", "MA:0000886" ; oboInOwl:hasExactSynonym "forebrain pia mater of neuraxis", "pia mater of forebrain", "pia mater of neuraxis of forebrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003550" ; a owl:Class ; rdfs:label "forebrain pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0003551 obo:IAO_0000115 "A pia mater that is part of a midbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Pia mater that is part of the midbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001175", "EMAPA:17794", "MA:0001061", "RETIRED_EHDAA2:0001110", "VHOG:0000467" ; oboInOwl:hasExactSynonym "midbrain pia mater of neuraxis", "pia mater of midbrain", "pia mater of neuraxis of midbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalon pia mater" ; oboInOwl:id "UBERON:0003551" ; a owl:Class ; rdfs:label "midbrain pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0003552 obo:IAO_0000115 "A pia mater that is part of a telencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Pia mater that is part of the telencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001992", "EMAPA:17777", "MA:0000982", "VHOG:0000476" ; oboInOwl:hasExactSynonym "pia mater of neuraxis of telencephalon", "pia mater of telencephalon", "telencephalon pia mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003552" ; a owl:Class ; rdfs:label "telencephalon pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0003553 obo:IAO_0000115 "A pia mater that is part of a diencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Pia mater that is part of the diencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000400", "EMAPA:17767", "MA:0000829", "VHOG:0000475" ; oboInOwl:hasExactSynonym "between brain pia mater", "between brain pia mater of neuraxis", "diencephalon pia mater of neuraxis", "interbrain pia mater", "interbrain pia mater of neuraxis", "mature diencephalon pia mater", "mature diencephalon pia mater of neuraxis", "pia mater of between brain", "pia mater of diencephalon", "pia mater of interbrain", "pia mater of mature diencephalon", "pia mater of neuraxis of between brain", "pia mater of neuraxis of diencephalon", "pia mater of neuraxis of interbrain", "pia mater of neuraxis of mature diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003553" ; a owl:Class ; rdfs:label "diencephalon pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0003554 obo:IAO_0000115 "A pia mater that is part of a hindbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Pia mater that is part of the hindbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000772", "EMAPA:17786", "MA:0000990", "VHOG:0000466" ; oboInOwl:hasExactSynonym "hindbrain pia mater of neuraxis", "pia mater of hindbrain", "pia mater of neuraxis of hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombencephalon pia mater" ; oboInOwl:id "UBERON:0003554" ; a owl:Class ; rdfs:label "hindbrain pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0003555 obo:IAO_0000115 "A pia mater that is part of a spinal cord [Automatically generated definition]." ; obo:UBPROP_0000001 "The innermost of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001896", "EMAPA:17807", "MA:0001133", "NCIT:C49800", "UMLS:C1710148", "VHOG:0000468" ; oboInOwl:hasExactSynonym "pia mater of neuraxis of spinal cord", "pia mater of spinal cord", "spinal cord pia mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003555" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "spinal cord pia mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0003556 obo:IAO_0000115 "An arachnoid mater that is part of a forebrain [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17765", "EMAPA:17775", "EMAPA:37544", "MA:0000884" ; oboInOwl:hasExactSynonym "arachnoid mater of forebrain", "arachnoid mater of neuraxis of forebrain", "arachnoid of forebrain", "forebrain arachnoid", "forebrain arachnoid mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003556" ; a owl:Class ; rdfs:label "forebrain arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0003557 obo:IAO_0000115 "An arachnoid mater that is part of a midbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Arachnoid mater that is part of the midbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17792", "MA:0001059", "VHOG:0000233" ; oboInOwl:hasExactSynonym "arachnoid mater of midbrain", "arachnoid mater of neuraxis of midbrain", "arachnoid of midbrain", "midbrain arachnoid", "midbrain arachnoid mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalon arachnoid mater" ; oboInOwl:id "UBERON:0003557" ; a owl:Class ; rdfs:label "midbrain arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0003558 obo:IAO_0000115 "An arachnoid mater that is part of a diencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Arachnoid mater that is part of the diencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17765", "MA:0000827", "VHOG:0000231" ; oboInOwl:hasExactSynonym "arachnoid mater of between brain", "arachnoid mater of diencephalon", "arachnoid mater of interbrain", "arachnoid mater of mature diencephalon", "arachnoid mater of neuraxis of between brain", "arachnoid mater of neuraxis of diencephalon", "arachnoid mater of neuraxis of interbrain", "arachnoid mater of neuraxis of mature diencephalon", "arachnoid of between brain", "arachnoid of diencephalon", "arachnoid of interbrain", "arachnoid of mature diencephalon", "between brain arachnoid", "between brain arachnoid mater", "between brain arachnoid mater of neuraxis", "diencephalon arachnoid", "diencephalon arachnoid mater of neuraxis", "interbrain arachnoid", "interbrain arachnoid mater", "interbrain arachnoid mater of neuraxis", "mature diencephalon arachnoid", "mature diencephalon arachnoid mater", "mature diencephalon arachnoid mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003558" ; a owl:Class ; rdfs:label "diencephalon arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0003559 obo:IAO_0000115 "An arachnoid mater that is part of a hindbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Arachnoid mater that is part of the hindbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17784", "MA:0000988", "VHOG:0000236" ; oboInOwl:hasExactSynonym "arachnoid mater of hindbrain", "arachnoid mater of neuraxis of hindbrain", "arachnoid of hindbrain", "hindbrain arachnoid", "hindbrain arachnoid mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombencephalon arachnoid mater" ; oboInOwl:id "UBERON:0003559" ; a owl:Class ; rdfs:label "hindbrain arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0003560 obo:IAO_0000115 "An arachnoid mater that is part of a spinal cord [Automatically generated definition]." ; obo:UBPROP_0000001 "The middle membrane of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17805", "MA:0001131", "VHOG:0000234" ; oboInOwl:hasExactSynonym "arachnoid mater of neuraxis of spinal cord", "arachnoid mater of spinal cord", "arachnoid of spinal cord", "spinal cord arachnoid", "spinal cord arachnoid mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003560" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "spinal cord arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0003561 obo:IAO_0000115 "A dura mater that is part of a forebrain." ; oboInOwl:hasDbXref "EMAPA:17766", "EMAPA:37545", "MA:0000885" ; oboInOwl:hasExactSynonym "dura mater of forebrain", "dura mater of neuraxis of forebrain", "forebrain dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003561" ; a owl:Class ; rdfs:label "forebrain dura mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0003562 obo:IAO_0000115 "A dura mater that is part of a midbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Dura mater that is part of the midbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17793", "MA:0001060", "VHOG:0000410" ; oboInOwl:hasExactSynonym "dura mater of midbrain", "dura mater of neuraxis of midbrain", "midbrain dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesencephalon dura mater" ; oboInOwl:id "UBERON:0003562" ; a owl:Class ; rdfs:label "midbrain dura mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0003563 obo:IAO_0000115 "A dura mater that is part of a telencephalon [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:17776", "MA:0000981" ; oboInOwl:hasExactSynonym "dura mater of neuraxis of telencephalon", "dura mater of telencephalon", "telencephalon dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003563" ; a owl:Class ; rdfs:label "telencephalon dura mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0003564 obo:IAO_0000115 "A dura mater that is part of a diencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Dura mater that is part of the diencephalon. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17766", "MA:0000828", "VHOG:0000258" ; oboInOwl:hasExactSynonym "between brain dura mater", "between brain dura mater of neuraxis", "diencephalon dura mater of neuraxis", "dura mater of between brain", "dura mater of diencephalon", "dura mater of interbrain", "dura mater of mature diencephalon", "dura mater of neuraxis of between brain", "dura mater of neuraxis of diencephalon", "dura mater of neuraxis of interbrain", "dura mater of neuraxis of mature diencephalon", "interbrain dura mater", "interbrain dura mater of neuraxis", "mature diencephalon dura mater", "mature diencephalon dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003564" ; a owl:Class ; rdfs:label "diencephalon dura mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0003565 obo:IAO_0000115 "A dura mater that is part of a hindbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Dura mater that is part of the hindbrain. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:17785", "MA:0000989", "VHOG:0000409" ; oboInOwl:hasExactSynonym "dura mater of hindbrain", "dura mater of neuraxis of hindbrain", "hindbrain dura mater of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombencephalon dura mater" ; oboInOwl:id "UBERON:0003565" ; a owl:Class ; rdfs:label "hindbrain dura mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0003566 obo:IAO_0000115 "A portion of connective tissue that is part of a head [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:16098", "MA:0000577" ; oboInOwl:hasExactSynonym "adult head connective tissue", "adult head portion of connective tissue", "adult head textus connectivus", "connective tissue of adult head", "connective tissue of head", "head portion of connective tissue", "head textus connectivus", "portion of connective tissue of adult head", "portion of connective tissue of head", "textus connectivus of adult head", "textus connectivus of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003566" ; a owl:Class ; rdfs:label "head connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0003567 obo:IAO_0000115 "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000519" ; oboInOwl:hasExactSynonym "abdomen portion of connective tissue", "abdomen textus connectivus", "connective tissue of abdomen", "portion of connective tissue of abdomen", "textus connectivus of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003567" ; a owl:Class ; rdfs:label "abdomen connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003568 obo:IAO_0000115 "A portion of connective tissue that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37250", "MA:0000585" ; oboInOwl:hasExactSynonym "connective tissue of neck", "connective tissue of neck (volume)", "neck (volume) connective tissue", "neck (volume) portion of connective tissue", "neck (volume) textus connectivus", "neck portion of connective tissue", "neck textus connectivus", "portion of connective tissue of neck", "portion of connective tissue of neck (volume)", "textus connectivus of neck", "textus connectivus of neck (volume)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003568" ; a owl:Class ; rdfs:label "neck connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0003569 obo:IAO_0000115 "A portion of connective tissue that is part of a leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37324", "MA:0000671" ; oboInOwl:hasExactSynonym "connective tissue of leg", "leg portion of connective tissue", "leg textus connectivus", "portion of connective tissue of leg", "textus connectivus of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003569" ; a owl:Class ; rdfs:label "leg connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0003570 obo:IAO_0000115 "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35968", "EMAPA:35977", "MA:0001814" ; oboInOwl:hasExactSynonym "apparatus respiratorius connective tissue", "apparatus respiratorius portion of connective tissue", "apparatus respiratorius textus connectivus", "connective tissue of apparatus respiratorius", "connective tissue of respiratory system", "portion of connective tissue of apparatus respiratorius", "portion of connective tissue of respiratory system", "respiratory system portion of connective tissue", "respiratory system textus connectivus", "textus connectivus of apparatus respiratorius", "textus connectivus of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003570" ; a owl:Class ; rdfs:label "respiratory system connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003571 obo:IAO_0000115 "A portion of connective tissue that is part of a trachea." ; oboInOwl:hasDbXref "EMAPA:35876", "MA:0001853" ; oboInOwl:hasExactSynonym "connective tissue of trachea", "connective tissue of windpipe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003571" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "trachea connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0009505 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0003572 obo:IAO_0000115 "A portion of connective tissue that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37254", "MA:0000550" ; oboInOwl:hasExactSynonym "anterior thoracic region connective tissue", "anterior thoracic region portion of connective tissue", "anterior thoracic region textus connectivus", "anterolateral part of thorax connective tissue", "anterolateral part of thorax portion of connective tissue", "anterolateral part of thorax textus connectivus", "chest portion of connective tissue", "chest textus connectivus", "connective tissue of anterior thoracic region", "connective tissue of anterolateral part of thorax", "connective tissue of chest", "connective tissue of front of thorax", "front of thorax connective tissue", "front of thorax portion of connective tissue", "front of thorax textus connectivus", "portion of connective tissue of anterior thoracic region", "portion of connective tissue of anterolateral part of thorax", "portion of connective tissue of chest", "portion of connective tissue of front of thorax", "textus connectivus of anterior thoracic region", "textus connectivus of anterolateral part of thorax", "textus connectivus of chest", "textus connectivus of front of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003572" ; a owl:Class ; rdfs:label "chest connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0003573 obo:IAO_0000115 "A portion of connective tissue that is part of an arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37316", "MA:0000593" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003573" ; a owl:Class ; rdfs:label "arm connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0003574 obo:IAO_0000115 "A portion of connective tissue that is part of a elbow [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37318", "MA:0000609" ; oboInOwl:hasExactSynonym "connective tissue of cubital region", "connective tissue of elbow", "textus connectivus of cubital region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003574" ; a owl:Class ; rdfs:label "elbow connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003318 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001461 ] ) ] . obo:UBERON_0003575 obo:IAO_0000115 "A portion of connective tissue that is part of a wrist [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37320", "MA:0000636" ; oboInOwl:hasExactSynonym "carpal region connective tissue", "connective tissue of carpal region", "connective tissue of wrist" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003575" ; a owl:Class ; rdfs:label "wrist connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003319 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ] . obo:UBERON_0003576 obo:IAO_0000115 "A portion of connective tissue that is part of a hip [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37323", "MA:0000656" ; oboInOwl:hasExactSynonym "connective tissue of hip", "connective tissue of hip region", "connective tissue of regio coxae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003576" ; a owl:Class ; rdfs:label "hip connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003320 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] . obo:UBERON_0003577 obo:IAO_0000115 "A portion of connective tissue that is part of a knee [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37326", "MA:0000667" ; oboInOwl:hasExactSynonym "connective tissue of knee", "knee portion of connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003577" ; a owl:Class ; rdfs:label "knee connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003321 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid128814 ] . obo:UBERON_0003578 obo:IAO_0000115 "A portion of connective tissue that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37330", "MA:0000647" ; oboInOwl:hasExactSynonym "connective tissue of digit of foot", "connective tissue of digitus pedis", "connective tissue of foot digit", "connective tissue of toe", "digitus pedis textus connectivus", "foot digit connective tissue", "hind limb digit connective tissue" ; oboInOwl:hasNarrowSynonym "foot digit connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003578" ; a owl:Class ; rdfs:label "pedal digit connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005255 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003579 obo:IAO_0000115 "A portion of connective tissue that is part of a shoulder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37315", "MA:0000632" ; oboInOwl:hasExactSynonym "connective tissue of shoulder", "portion of connective tissue of shoulder", "shoulder portion of connective tissue", "shoulder textus connectivus", "textus connectivus of shoulder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003579" ; a owl:Class ; rdfs:label "shoulder connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003322 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0003580 obo:IAO_0000115 "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37548", "MA:0002409" ; oboInOwl:hasExactSynonym "connective tissue of lower respiratory tract", "lower respiratory tract portion of connective tissue", "lower respiratory tract textus connectivus", "portion of connective tissue of lower respiratory tract", "textus connectivus of lower respiratory tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003580" ; a owl:Class ; rdfs:label "lower respiratory tract connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] . obo:UBERON_0003581 obo:IAO_0000115 "A portion of connective tissue that is part of a eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37532", "MA:0001251", "NCIT:C49482", "UMLS:C1707989" ; oboInOwl:hasExactSynonym "blepharon connective tissue", "connective tissue of blepharon", "connective tissue of eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003581" ; a owl:Class ; rdfs:label "eyelid connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0010330 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0003582 obo:IAO_0000115 "A portion of connective tissue that is part of a nasopharynx [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37682", "MA:0001864" ; oboInOwl:hasExactSynonym "connective tissue of nasal part of pharynx", "connective tissue of nasopharynx", "connective tissue of rhinopharynx", "nasal part of pharynx connective tissue", "nasal part of pharynx portion of connective tissue", "nasal part of pharynx textus connectivus", "nasopharynx portion of connective tissue", "nasopharynx textus connectivus", "portion of connective tissue of nasal part of pharynx", "portion of connective tissue of nasopharynx", "portion of connective tissue of rhinopharynx", "rhinopharynx connective tissue", "rhinopharynx portion of connective tissue", "rhinopharynx textus connectivus", "textus connectivus of nasal part of pharynx", "textus connectivus of nasopharynx", "textus connectivus of rhinopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003582" ; a owl:Class ; rdfs:label "nasopharynx connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0003583 obo:IAO_0000115 "A portion of connective tissue that is part of a larynx [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35471", "MA:0001754", "NCIT:C49245", "UMLS:C1708651" ; oboInOwl:hasExactSynonym "connective tissue of larynx", "larynx portion of connective tissue", "larynx textus connectivus", "portion of connective tissue of larynx", "textus connectivus of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laryngeal connective tissue" ; oboInOwl:id "UBERON:0003583" ; a owl:Class ; rdfs:label "larynx connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0003584 obo:IAO_0000115 "The fibrous supportive tissue of the mammary gland." ; oboInOwl:hasDbXref "EMAPA:35537", "FMA:74479", "FMA:74483", "MA:0002897" ; oboInOwl:hasExactSynonym "connective tissue of lactiferous gland", "connective tissue of lobe of breast", "connective tissue of lobe of mammary gland", "connective tissue of mammary gland", "lactiferous gland connective tissue", "lactiferous gland portion of connective tissue", "lactiferous gland stroma", "mammary gland stroma", "mammary stroma", "stroma of lactiferous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003584" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mammary gland connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001911 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003326 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0003585 obo:IAO_0000115 "A portion of connective tissue that is part of a dermis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36509", "MA:0000799" ; oboInOwl:hasExactSynonym "connective tissue of dermis", "dermis portion of connective tissue", "dermis textus connectivus", "portion of connective tissue of dermis", "textus connectivus of dermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003585" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dermis connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004016 ], _:genid130003 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:UBERON_0003586 obo:IAO_0000115 "A portion of connective tissue that is part of a trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37252", "MA:0000513" ; oboInOwl:hasExactSynonym "connective tissue of torso", "connective tissue of trunk", "portion of connective tissue of torso", "portion of connective tissue of trunk", "textus connectivus of torso", "textus connectivus of trunk", "torso connective tissue", "torso portion of connective tissue", "torso textus connectivus", "trunk portion of connective tissue", "trunk textus connectivus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003586" ; a owl:Class ; rdfs:label "trunk connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0003587 obo:IAO_0000115 "A portion of connective tissue that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37313", "MA:0000689" ; oboInOwl:hasExactSynonym "connective tissue of limb", "limb portion of connective tissue", "limb textus connectivus", "portion of connective tissue of limb", "textus connectivus of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003587" ; a owl:Class ; rdfs:label "limb connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0009749 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003588 obo:IAO_0000115 "A portion of connective tissue that is part of a forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37314", "MA:0000613" ; oboInOwl:hasExactSynonym "connective tissue of anteriormost limb", "connective tissue of fore limb", "connective tissue of forelimb", "connective tissue of superior member", "connective tissue of upper extremity" ; oboInOwl:hasNarrowSynonym "wing connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003588" ; a owl:Class ; rdfs:label "forelimb connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003859 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003589 obo:IAO_0000115 "A portion of connective tissue that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37322", "MA:0000661" ; oboInOwl:hasExactSynonym "connective tissue of hind limb", "connective tissue of hindlimb", "connective tissue of inferior member", "connective tissue of lower extremity", "hind limb connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003589" ; a owl:Class ; rdfs:label "hindlimb connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003860 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003592 obo:IAO_0000115 "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32690", "EMAPA:35193", "MA:0001831", "NCIT:C49210", "UMLS:C1707052" ; oboInOwl:hasExactSynonym "bronchi connective tissue", "bronchi portion of connective tissue", "bronchi textus connectivus", "bronchial trunk connective tissue", "bronchial trunk portion of connective tissue", "bronchial trunk textus connectivus", "bronchus portion of connective tissue", "bronchus textus connectivus", "connective tissue of bronchi", "connective tissue of bronchial trunk", "connective tissue of bronchus", "portion of connective tissue of bronchi", "portion of connective tissue of bronchial trunk", "portion of connective tissue of bronchus", "textus connectivus of bronchi", "textus connectivus of bronchial trunk", "textus connectivus of bronchus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchial connective tissue", "bronchial mesenchyme" ; oboInOwl:id "UBERON:0003592" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchus connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid128990 ] . obo:UBERON_0003593 obo:IAO_0000115 "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37255", "MA:0000555" ; oboInOwl:hasExactSynonym "cavity of chest connective tissue", "cavity of chest portion of connective tissue", "cavity of chest textus connectivus", "cavity of thorax connective tissue", "cavity of thorax portion of connective tissue", "cavity of thorax textus connectivus", "chest cavity connective tissue", "chest cavity portion of connective tissue", "chest cavity textus connectivus", "connective tissue of cavity of chest", "connective tissue of cavity of thorax", "connective tissue of chest cavity", "connective tissue of pectoral cavity", "connective tissue of thoracic cavity", "pectoral cavity connective tissue", "pectoral cavity portion of connective tissue", "pectoral cavity textus connectivus", "portion of connective tissue of cavity of chest", "portion of connective tissue of cavity of thorax", "portion of connective tissue of chest cavity", "portion of connective tissue of pectoral cavity", "portion of connective tissue of thoracic cavity", "textus connectivus of cavity of chest", "textus connectivus of cavity of thorax", "textus connectivus of chest cavity", "textus connectivus of pectoral cavity", "textus connectivus of thoracic cavity", "thoracic cavity portion of connective tissue", "thoracic cavity textus connectivus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003593" ; a owl:Class ; rdfs:label "thoracic cavity connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0003594 obo:IAO_0000115 "A portion of connective tissue that is part of a pelvis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37257", "MA:0000533" ; oboInOwl:hasExactSynonym "connective tissue of pelvis", "pelvis portion of connective tissue", "pelvis textus connectivus", "portion of connective tissue of pelvis", "textus connectivus of pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003594" ; a owl:Class ; rdfs:label "pelvis connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0003595 obo:IAO_0000115 "A portion of connective tissue that is part of a foot [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37329", "MA:0000644" ; oboInOwl:hasExactSynonym "connective tissue of foot", "connective tissue of terminal segment of free lower limb", "foot connective tissue", "textus connectivus of pes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003595" ; a owl:Class ; rdfs:label "pes connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003328 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid129061 ] . obo:UBERON_0003596 obo:IAO_0000115 "A portion of connective tissue that is part of an ankle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37328", "MA:0000639" ; oboInOwl:hasExactSynonym "connective tissue of ankle", "tarsal region connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003596" ; a owl:Class ; rdfs:label "ankle connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0010695 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] . obo:UBERON_0003597 obo:IAO_0000115 "A portion of connective tissue that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37321", "MA:0000623" ; oboInOwl:hasExactSynonym "connective tissue of digit of hand", "connective tissue of digitus manus", "connective tissue of finger", "connective tissue of hand digit", "fore limb digit connective tissue", "hand digit connective tissue" ; oboInOwl:hasNarrowSynonym "hand digit connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003597" ; a owl:Class ; rdfs:label "manual digit connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005257 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003598 obo:IAO_0000115 "A portion of connective tissue that is part of a hand [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35392", "MA:0000620" ; oboInOwl:hasExactSynonym "connective tissue of hand", "connective tissue of terminal segment of free upper limb", "hand connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003598" ; a owl:Class ; rdfs:label "manus connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0009523 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0003599 obo:IAO_0000115 "A portion of connective tissue that is part of a tail [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:16749", "MA:0000697" ; oboInOwl:hasExactSynonym "connective tissue of post-vent region", "connective tissue of tail", "portion of connective tissue of post-vent region", "portion of connective tissue of tail", "post-vent region connective tissue", "post-vent region portion of connective tissue", "post-vent region textus connectivus", "tail portion of connective tissue", "tail textus connectivus", "textus connectivus of post-vent region", "textus connectivus of tail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003599" ; a owl:Class ; rdfs:label "tail connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0003601 obo:IAO_0000115 "A cartilage that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37251", "MA:0000586" ; oboInOwl:hasExactSynonym "cartilage of neck", "cartilage of neck (volume)", "neck (volume) cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003601" ; a owl:Class ; rdfs:label "neck cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0003603 obo:IAO_0000115 "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37547", "MA:0001819", "NCIT:C49256", "UMLS:C1708759" ; oboInOwl:hasExactSynonym "cartilage of lower respiratory tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003603" ; a owl:Class ; rdfs:label "lower respiratory tract cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] . obo:UBERON_0003604 obo:IAO_0000115 "The ring-shaped cartilaginous structures that support the trachea." ; obo:IAO_0000116 "check whether to classify as part of splanchoncranium" ; obo:UBPROP_0000008 "in mammals the rings are incomplete, in avians the rings are complete." ; oboInOwl:hasDbXref "EMAPA:18699", "EMAPA:35875", "FMA:7434", "MA:0001857", "NCIT:C49304", "SCTID:278979006", "UMLS:C1710456", "Wikipedia:Tracheal_rings" ; oboInOwl:hasExactSynonym "cartilage of trachea", "cartilage of windpipe", "cartilaginous ring of trachea", "cartilaginous trachea cartilage", "cartilago trachealis", "tracheal cartilage", "windpipe cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilage of the trachea", "cartilagines tracheales", "ring of the trachea", "trachea ring", "tracheal ring" ; oboInOwl:id "UBERON:0003604" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "trachea cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007267 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png"^^xsd:anyURI . obo:UBERON_0003605 obo:IAO_0000115 "A skin gland that is part of a camera-type eye [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37530", "MA:0002451" ; oboInOwl:hasExactSynonym "camera-type eye skin gland", "camera-type eye skin glands", "camera-type eye skin glands set", "skin gland of camera-type eye", "skin gland of vertebrate eye", "skin glands of camera-type eye", "skin glands of vertebrate eye", "skin glands set of camera-type eye", "skin glands set of vertebrate eye", "vertebrate eye skin gland", "vertebrate eye skin glands", "vertebrate eye skin glands set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003605" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "eye skin gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002419 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0003606 obo:IAO_0000115 "A long bone that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35495", "MA:0000298" ; oboInOwl:hasExactSynonym "long bone of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003606" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "limb long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002495 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003607 obo:IAO_0000115 "A long bone that is part of a forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35350", "MA:0000299" ; oboInOwl:hasExactSynonym "anteriormost limb long bone", "fore limb long bone", "long bone of anteriormost limb", "long bone of fore limb", "long bone of forelimb", "long bone of superior member", "long bone of upper extremity", "superior member long bone", "upper extremity long bone" ; oboInOwl:hasNarrowSynonym "wing long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003607" ; a owl:Class ; rdfs:label "forelimb long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002495 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003608 obo:IAO_0000115 "A long bone that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35403", "MA:0000300" ; oboInOwl:hasExactSynonym "hind limb long bone", "inferior member long bone", "long bone of hind limb", "long bone of hindlimb", "long bone of inferior member", "long bone of lower extremity", "lower extremity long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003608" ; a owl:Class ; rdfs:label "hindlimb long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002495 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003609 obo:IAO_0000115 "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." ; oboInOwl:hasDbXref "MA:0002859" ; oboInOwl:hasExactSynonym "adult aorta elastic connective tissue", "adult aorta elastic tissue", "adult aorta textus connectivus elasticus", "aorta elastic connective tissue", "aorta elastic lamina", "aorta elastic laminae", "aorta textus connectivus elasticus", "dorsal aorta elastic connective tissue", "dorsal aorta elastic tissue", "dorsal aorta textus connectivus elasticus", "elastic connective tissue of adult aorta", "elastic connective tissue of aorta", "elastic connective tissue of dorsal aorta", "elastic connective tissue of trunk of aortic tree", "elastic tissue of adult aorta", "elastic tissue of aorta", "elastic tissue of dorsal aorta", "elastic tissue of trunk of aortic tree", "textus connectivus elasticus of adult aorta", "textus connectivus elasticus of aorta", "textus connectivus elasticus of dorsal aorta", "textus connectivus elasticus of trunk of aortic tree", "trunk of aortic tree elastic connective tissue", "trunk of aortic tree elastic tissue", "trunk of aortic tree textus connectivus elasticus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003609" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta elastic tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0003610 obo:IAO_0000115 "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." ; oboInOwl:hasDbXref "MA:0002858" ; oboInOwl:hasExactSynonym "cardiac elastic tissue", "elastic connective tissue of heart", "elastic tissue of heart", "heart elastic connective tissue", "heart textus connectivus elasticus", "textus connectivus elasticus of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003610" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "heart elastic tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0003611 obo:IAO_0000115 "An elastic tissue that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37579", "MA:0001820" ; oboInOwl:hasExactSynonym "apparatus respiratorius elastic connective tissue", "apparatus respiratorius elastic tissue", "apparatus respiratorius textus connectivus elasticus", "elastic connective tissue of apparatus respiratorius", "elastic connective tissue of respiratory system", "elastic tissue of apparatus respiratorius", "elastic tissue of respiratory system", "respiratory system elastic connective tissue", "respiratory system textus connectivus elasticus", "textus connectivus elasticus of apparatus respiratorius", "textus connectivus elasticus of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003611" ; a owl:Class ; rdfs:label "respiratory system elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003613 obo:IAO_0000115 "An elastic tissue that is part of a circulatory system [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0002857" ; oboInOwl:hasExactSynonym "cardiovascular system elastic connective tissue", "cardiovascular system textus connectivus elasticus", "circulatory system elastic connective tissue", "circulatory system elastic tissue", "circulatory system textus connectivus elasticus", "elastic connective tissue of cardiovascular system", "elastic connective tissue of circulatory system", "elastic tissue of cardiovascular system", "elastic tissue of circulatory system", "textus connectivus elasticus of cardiovascular system", "textus connectivus elasticus of circulatory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003613" ; a owl:Class ; rdfs:label "cardiovascular system elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ] ) ] . obo:UBERON_0003614 obo:IAO_0000115 "Elastic tissue layer that lines a blood vessel layer." ; oboInOwl:hasBroadSynonym "elastic lamina", "elastic laminae" ; oboInOwl:hasDbXref "EMAPA:36300", "MA:0002856" ; oboInOwl:hasExactSynonym "blood vessel elastic connective tissue", "blood vessel textus connectivus elasticus", "elastic connective tissue of blood vessel", "elastic tissue of blood vessel", "textus connectivus elasticus of blood vessel", "vascular elastic lamina", "vascular elastic laminae", "vascular elastic tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003614" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "blood vessel elastic tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0003615 obo:IAO_0000115 "Elastic tissue that is part of a lung [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0002860" ; oboInOwl:hasExactSynonym "elastic connective tissue of lung", "elastic tissue of lung", "lung elastic connective tissue", "lung textus connectivus elasticus", "textus connectivus elasticus of lung" ; oboInOwl:hasNarrowSynonym "pulmonary elastic fiber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003615" ; a owl:Class ; rdfs:label "lung elastic tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0003616 obo:IAO_0000115 "An elastic tissue that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0001838", "NCIT:C49211", "UMLS:C1707053" ; oboInOwl:hasExactSynonym "bronchi elastic connective tissue", "bronchi elastic tissue", "bronchi textus connectivus elasticus", "bronchial trunk elastic connective tissue", "bronchial trunk elastic tissue", "bronchial trunk textus connectivus elasticus", "bronchus elastic connective tissue", "bronchus textus connectivus elasticus", "elastic connective tissue of bronchi", "elastic connective tissue of bronchial trunk", "elastic connective tissue of bronchus", "elastic tissue of bronchi", "elastic tissue of bronchial trunk", "elastic tissue of bronchus", "textus connectivus elasticus of bronchi", "textus connectivus elasticus of bronchial trunk", "textus connectivus elasticus of bronchus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003616" ; a owl:Class ; rdfs:label "bronchus elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001957 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0003617 obo:IAO_0000115 "An elastic tissue that is part of a trachea [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0001861" ; oboInOwl:hasExactSynonym "cartilaginous trachea elastic connective tissue", "cartilaginous trachea elastic tissue", "cartilaginous trachea textus connectivus elasticus", "elastic connective tissue of cartilaginous trachea", "elastic connective tissue of vertebrate trachea", "elastic connective tissue of windpipe", "elastic tissue of cartilaginous trachea", "elastic tissue of vertebrate trachea", "elastic tissue of windpipe", "textus connectivus elasticus of cartilaginous trachea", "textus connectivus elasticus of vertebrate trachea", "textus connectivus elasticus of windpipe", "vertebrate trachea elastic connective tissue", "vertebrate trachea elastic tissue", "vertebrate trachea textus connectivus elasticus", "windpipe elastic connective tissue", "windpipe elastic tissue", "windpipe textus connectivus elasticus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003617" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "trachea elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002202 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0003618 obo:IAO_0000115 "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." ; oboInOwl:hasDbXref "EMAPA:35138", "FMA:74433", "MA:0002903", "SCTID:48467007" ; oboInOwl:hasExactSynonym "adult aorta tunica media", "dorsal aorta tunica media", "trunk of aortic tree tunica media", "tunica media of adult aorta", "tunica media of aorta", "tunica media of dorsal aorta", "tunica media of trunk of aortic tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003618" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta tunica media" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004663 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004663 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0003619 obo:IAO_0000115 "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." ; oboInOwl:hasDbXref "BTO:0005553", "EMAPA:35137", "FMA:74419", "MA:0002904", "SCTID:362031007" ; oboInOwl:hasExactSynonym "adult aorta tunica intima", "dorsal aorta tunica intima", "trunk of aortic tree tunica intima", "tunica intima of adult aorta", "tunica intima of aorta", "tunica intima of dorsal aorta", "tunica intima of trunk of aortic tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003619" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta tunica intima" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004663 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004663 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002523 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0003620 obo:IAO_0000115 "A phalanx that is part of a hand digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19113", "FMA:35477", "MA:0001389", "NCIT:C52777", "SCTID:181975002", "UMLS:C1711344" ; oboInOwl:hasExactSynonym "fore limb digit 1 phalanx", "hand digit 1 phalanx", "manual digit I phalanx", "phalanx of hand digit 1", "phalanx of thumb", "thumb phalanx" ; oboInOwl:hasNarrowSynonym "hand digit 1 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003620" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 1 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101463 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010675 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0003622 obo:IAO_0000115 "2nd digit of the manus." ; obo:UBPROP_0000007 "indicis" ; obo:UBPROP_0000008 "Anurans lack manual digit 1, so manual digit 2 is the digit after the prepollex (Phenotype RCN Oct 2012)", "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." ; oboInOwl:hasDbXref "AAO:0010640", "EHDAA2:0000517", "EMAPA:17432", "FMA:24946", "MA:0000455", "NCIT:C52835", "SCTID:362758006", "UMLS:C0230388", "Wikipedia:Index_finger" ; oboInOwl:hasExactSynonym "2nd digit of hand", "2nd finger", "digit 2 of fore-paw", "finger 2", "fore digit II", "fore limb digit 2", "hand digit 2", "manual digit II", "second digit of hand", "second finger" ; oboInOwl:hasNarrowSynonym "hand digit 2", "index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003622" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 2" ; rdfs:subClassOf obo:UBERON_0002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003622 ], _:genid130479 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d5/Index_finger.JPG"^^xsd:anyURI . obo:UBERON_0003623 obo:IAO_0000115 "3rd digit of the manus." ; obo:UBPROP_0000008 "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." ; oboInOwl:hasDbXref "AAO:0010641", "EHDAA2:0000523", "EMAPA:17435", "FMA:24947", "MA:0000456", "NCIT:C52836", "SCTID:362763005", "UMLS:C0230393", "Wikipedia:Middle_finger" ; oboInOwl:hasExactSynonym "3rd digit of hand", "3rd finger", "digit 3 of fore-paw", "finger 3", "fore digit III", "fore limb digit 3", "hand digit 3", "manual digit III", "third digit of hand", "third finger" ; oboInOwl:hasNarrowSynonym "hand digit 3", "middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus medius", "long finger" ; oboInOwl:id "UBERON:0003623" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 3" ; rdfs:subClassOf obo:UBERON_0002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003623 ], _:genid130497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fd/Middle_finger.jpg"^^xsd:anyURI . obo:UBERON_0003624 obo:IAO_0000115 "4th digit of the manus." ; oboInOwl:hasDbXref "AAO:0010642", "EHDAA2:0000529", "EMAPA:17438", "FMA:24948", "MA:0000457", "NCIT:C52837", "SCTID:362768001", "UMLS:C0230398", "Wikipedia:Ring_finger" ; oboInOwl:hasExactSynonym "4th digit of hand", "4th finger", "digit 4 of fore-paw", "finger 4", "fore digit IV", "fore limb digit 4", "fourth digit of hand", "fourth finger", "hand digit 4", "manual digit IV" ; oboInOwl:hasNarrowSynonym "hand digit 4", "ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus annularis" ; oboInOwl:id "UBERON:0003624" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 4" ; rdfs:subClassOf obo:UBERON_0002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003624 ], _:genid130517 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/1/14/Ring_finger.JPG"^^xsd:anyURI . obo:UBERON_0003625 obo:IAO_0000115 "5th digit of the manus." ; oboInOwl:hasDbXref "AAO:0010643", "EHDAA2:0000535", "EMAPA:17441", "FMA:24949", "MA:0000458", "NCIT:C52838", "SCTID:362773007", "UMLS:C0230403", "Wikipedia:Little_finger" ; oboInOwl:hasExactSynonym "5th digit of hand", "5th finger", "digit 5 of fore-paw", "fifth digit of hand", "fifth finger", "finger 5", "fore digit V", "fore limb digit 5", "hand digit 5", "manual digit V" ; oboInOwl:hasNarrowSynonym "hand digit 5", "little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digitus V", "manual digitus minimus", "manus digiti minimi", "manus quintus" ; oboInOwl:id "UBERON:0003625" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 5" ; rdfs:subClassOf obo:UBERON_0002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003625 ], _:genid130535 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Pink.jpg"^^xsd:anyURI . obo:UBERON_0003631 obo:IAO_0000115 "1st digit of the hind autopod." ; oboInOwl:hasDbXref "AAO:0010644", "BTO:0002349", "EHDAA2:0002037", "EMAPA:17460", "FMA:25047", "GAID:45", "MA:0000465", "MESH:D006214", "NCIT:C52839", "SCTID:21699005", "SCTID:302546000", "UMLS:C1708079", "VSAO:0000201", "Wikipedia:Hallux" ; oboInOwl:hasExactSynonym "digit 1 of hind-paw", "digit 1 of pes", "digitus primus pedis", "foot digit 1", "great toe", "hallex", "hallux", "hallux; digitus primus [I]", "hind digit 1", "hind digit I", "hind limb digit 1", "pedal digit 1", "pedal digit I", "pes digit I", "preaxial digit of hindlimb", "toe 1" ; oboInOwl:hasNarrowSynonym "big toe", "foot digit 1", "hindlimb dewclaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus primus (I) pedis", "first toe", "large toe" ; oboInOwl:id "UBERON:0003631" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 1" ; rdfs:subClassOf obo:UBERON_0001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003631 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0002387 ], _:genid130555 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/RightFootToes.jpg"^^xsd:anyURI . obo:UBERON_0003632 obo:IAO_0000115 "2nd digit of the hind autopod." ; oboInOwl:hasDbXref "AAO:0010645", "BTO:0002350", "EHDAA2:0002042", "EMAPA:17463", "FMA:25048", "MA:0000466", "NCIT:C52840", "SCTID:362817008", "UMLS:C1708081" ; oboInOwl:hasExactSynonym "2nd toe", "digit 2 of hind-paw", "digitus secundus [ii]", "digitus secundus pedis", "foot digit 2", "hind digit 2", "hind digit II", "hind limb digit 2", "pedal digit II", "pes digit II", "second digit of foot", "second toe", "toe 2" ; oboInOwl:hasNarrowSynonym "foot digit 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus secundus (II) pedis" ; oboInOwl:id "UBERON:0003632" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 2" ; rdfs:subClassOf obo:UBERON_0001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003632 ], _:genid130580 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0003633 obo:IAO_0000115 "3rd digit of the hind autopod." ; oboInOwl:hasDbXref "AAO:0010646", "BTO:0002351", "EHDAA2:0002047", "EMAPA:17466", "FMA:25051", "MA:0000467", "NCIT:C52841", "SCTID:362821001", "UMLS:C1708083" ; oboInOwl:hasExactSynonym "3rd toe", "digit 3 of hind-paw", "digitus tertius (III) pedis", "digitus tertius [iii]", "digitus tertius pedis", "foot digit 3", "hind digit 3", "hind digit III", "hind limb digit 3", "pedal digit III", "pes digit III", "third digit of foot", "third toe", "toe 3" ; oboInOwl:hasNarrowSynonym "foot digit 3" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003633" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 3" ; rdfs:subClassOf obo:UBERON_0001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003633 ], _:genid130601 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0003634 obo:IAO_0000115 "4th digit of the hind autopod." ; oboInOwl:hasDbXref "AAO:0010656", "BTO:0002352", "EHDAA2:0002052", "EMAPA:17469", "FMA:25052", "MA:0000468", "NCIT:C52842", "SCTID:362826006", "UMLS:C1708085" ; oboInOwl:hasExactSynonym "4th toe", "digit 4 of hind-paw", "digitus quartis pedis", "digitus quartus [iv]", "foot digit 4", "fourth digit of foot", "fourth toe", "hind digit 4", "hind digit IV", "hind limb digit 4", "pedal digit IV", "pes digit IV", "toe 4" ; oboInOwl:hasNarrowSynonym "foot digit 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus quartus (IV) pedis" ; oboInOwl:id "UBERON:0003634" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 4" ; rdfs:subClassOf obo:UBERON_0001466, obo:UBERON_0006051, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003634 ] . obo:UBERON_0003635 obo:IAO_0000115 "5th digit of the hind autopod." ; oboInOwl:hasDbXref "AAO:0010658", "BTO:0002353", "EHDAA2:0002057", "EMAPA:17472", "FMA:25053", "MA:0000469", "NCIT:C52843", "SCTID:362830009", "UMLS:C1708087", "Wikipedia:Fifth_toe" ; oboInOwl:hasExactSynonym "5th toe", "digit 5 of hind-paw", "digitus V of pes", "digitus minimus pedis", "digitus minimus; digitus quintus [v]", "digitus quintus [V]", "digitus quintus [V] pedis", "digitus quintus of pes", "digitus quintus pedis", "fifth digit of foot", "fifth toe", "foot digit 5", "hind digit 5", "hind digit V", "hind limb digit 5", "pedal digit V", "pedal digitus minimus", "pes digit V", "toe 5" ; oboInOwl:hasNarrowSynonym "foot digit 5", "little toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitus quintus (V) pedis" ; oboInOwl:id "UBERON:0003635" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 5" ; rdfs:subClassOf obo:UBERON_0001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003635 ], _:genid130638 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png"^^xsd:anyURI . obo:UBERON_0003636 obo:IAO_0000115 "A phalanx that is part of a hand digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19115", "FMA:35480", "MA:0001390", "NCIT:C52776", "SCTID:361783009", "UMLS:C1708312" ; oboInOwl:hasExactSynonym "2 nd digit of hand digit long bone", "2 nd digit of hand long bone of digit", "2 nd digit of hand phalanx", "2 nd finger digit long bone", "2 nd finger long bone of digit", "2 nd finger phalanx", "digit long bone of 2 nd digit of hand", "digit long bone of 2 nd finger", "digit long bone of hand digit 2", "digit long bone of second finger", "fore limb digit 2 phalanx", "hand digit 2 digit long bone", "hand digit 2 long bone of digit", "hand digit 2 phalanx", "index finger phalanx", "long bone of digit of 2 nd digit of hand", "long bone of digit of 2 nd finger", "long bone of digit of hand digit 2", "long bone of digit of second finger", "manual digit II phalanx", "phalanx of 2 nd digit of hand", "phalanx of 2 nd finger", "phalanx of hand digit 2", "phalanx of index finger", "phalanx of manual digit 2", "phalanx of second finger", "second finger digit long bone", "second finger long bone of digit", "second finger phalanx" ; oboInOwl:hasNarrowSynonym "hand digit 2 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003636" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 2 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010676 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0003637 obo:IAO_0000115 "A phalanx that is part of a hand digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19117", "FMA:35483", "MA:0001391", "NCIT:C52775", "SCTID:361785002", "UMLS:C1708314" ; oboInOwl:hasExactSynonym "3 rd digit of hand digit long bone", "3 rd digit of hand long bone of digit", "3 rd digit of hand phalanx", "3 rd finger digit long bone", "3 rd finger long bone of digit", "3 rd finger phalanx", "digit long bone of 3 rd digit of hand", "digit long bone of 3 rd finger", "digit long bone of hand digit 3", "digit long bone of third finger", "fore limb digit 3 phalanx", "hand digit 3 digit long bone", "hand digit 3 long bone of digit", "hand digit 3 phalanx", "long bone of digit of 3 rd digit of hand", "long bone of digit of 3 rd finger", "long bone of digit of hand digit 3", "long bone of digit of third finger", "manual digit III phalanx", "middle finger phalanx", "phalanx of 3 rd digit of hand", "phalanx of 3 rd finger", "phalanx of hand digit 3", "phalanx of middle finger", "phalanx of third finger", "third finger digit long bone", "third finger long bone of digit", "third finger phalanx" ; oboInOwl:hasNarrowSynonym "hand digit 3 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003637" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 3 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010677 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0003638 obo:IAO_0000115 "A phalanx that is part of a hand digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19119", "FMA:35486", "MA:0001392", "NCIT:C52774", "SCTID:361787005", "UMLS:C1708316" ; oboInOwl:hasExactSynonym "4 th digit of hand digit long bone", "4 th digit of hand long bone of digit", "4 th digit of hand phalanx", "4 th finger digit long bone", "4 th finger long bone of digit", "4 th finger phalanx", "digit long bone of 4 th digit of hand", "digit long bone of 4 th finger", "digit long bone of fourth finger", "digit long bone of hand digit 4", "fore limb digit 4 phalanx", "fourth finger digit long bone", "fourth finger long bone of digit", "fourth finger phalanx", "hand digit 4 digit long bone", "hand digit 4 long bone of digit", "hand digit 4 phalanx", "long bone of digit of 4 th digit of hand", "long bone of digit of 4 th finger", "long bone of digit of fourth finger", "long bone of digit of hand digit 4", "manual digit IV phalanx", "phalanx of 4 th digit of hand", "phalanx of 4 th finger", "phalanx of fourth finger", "phalanx of hand digit 4", "phalanx of ring finger", "ring finger phalanx" ; oboInOwl:hasNarrowSynonym "hand digit 4 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003638" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 4 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103624 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010678 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0003639 obo:IAO_0000115 "A phalanx that is part of a hand digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19121", "FMA:35489", "MA:0001393", "NCIT:C52773", "SCTID:361789008", "UMLS:C1708317" ; oboInOwl:hasExactSynonym "5 th digit of hand digit long bone", "5 th digit of hand long bone of digit", "5 th digit of hand phalanx", "5 th finger digit long bone", "5 th finger long bone of digit", "5 th finger phalanx", "digit long bone of 5 th digit of hand", "digit long bone of 5 th finger", "digit long bone of fifth finger", "digit long bone of hand digit 5", "fifth finger digit long bone", "fifth finger long bone of digit", "fifth finger phalanx", "fore limb digit 5 phalanx", "hand digit 5 digit long bone", "hand digit 5 long bone of digit", "hand digit 5 phalanx", "little finger phalanx", "long bone of digit of 5 th digit of hand", "long bone of digit of 5 th finger", "long bone of digit of fifth finger", "long bone of digit of hand digit 5", "manual digit V phalanx", "phalanx of 5 th digit of hand", "phalanx of 5 th finger", "phalanx of 5th finger", "phalanx of fifth digit of hand", "phalanx of fifth finger", "phalanx of hand digit 5", "phalanx of little finger", "phalanx of manual digitus minimus" ; oboInOwl:hasNarrowSynonym "hand digit 5 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003639" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 5 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010679 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0003640 obo:IAO_0000115 "A phalanx that is part of a foot digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19124", "FMA:32884", "MA:0001381", "NCIT:C52778", "SCTID:361798006", "UMLS:C1708080" ; oboInOwl:hasExactSynonym "big toe phalanx", "digit long bone of foot digit 1", "digit long bone of hallux", "foot digit 1 digit long bone", "foot digit 1 long bone of digit", "foot digit 1 phalanx", "hallux digit long bone", "hallux long bone of digit", "hallux phalanx", "hind limb digit 1 phalanx", "long bone of digit of foot digit 1", "long bone of digit of hallux", "pedal digit I phalanx", "phalanx of big toe", "phalanx of first digit of foot", "phalanx of foot digit 1", "phalanx of great toe", "phalanx of hallux" ; oboInOwl:hasNarrowSynonym "foot digit 1 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "phalanx of first toe" ; oboInOwl:id "UBERON:0003640" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 1 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103631 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010680 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0003641 obo:IAO_0000115 "A phalanx that is part of a foot digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19126", "FMA:32899", "MA:0001382", "NCIT:C52779", "SCTID:361800004", "UMLS:C1708082" ; oboInOwl:hasExactSynonym "digit long bone of foot digit 2", "foot digit 2 digit long bone", "foot digit 2 long bone of digit", "foot digit 2 phalanx", "hind limb digit 2 phalanx", "long bone of digit of foot digit 2", "pedal digit II phalanx", "phalanx of foot digit 2", "phalanx of second toe", "second toe phalanx" ; oboInOwl:hasNarrowSynonym "foot digit 2 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003641" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 2 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010681 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0003642 obo:IAO_0000115 "A phalanx that is part of a foot digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19128", "FMA:32900", "MA:0001383", "NCIT:C52780", "SCTID:361802007", "UMLS:C1708084" ; oboInOwl:hasExactSynonym "digit long bone of foot digit 3", "foot digit 3 digit long bone", "foot digit 3 long bone of digit", "foot digit 3 phalanx", "hind limb digit 3 phalanx", "long bone of digit of foot digit 3", "pedal digit III phalanx", "phalanx of foot digit 3", "phalanx of third toe", "third toe phalanx" ; oboInOwl:hasNarrowSynonym "foot digit 3 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003642" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 3 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103633 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010682 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0003643 obo:IAO_0000115 "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37565", "MA:0001800" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003643" ; a owl:Class ; rdfs:label "respiratory system arterial blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003509 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003644 obo:IAO_0000115 "An arterial blood vessel that is part of a kidney [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:31436", "MA:0002578" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney arterial system" ; oboInOwl:id "UBERON:0003644" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney arterial blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003509 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0003645 obo:IAO_0000115 "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 1." ; obo:UBPROP_0000001 "The first metacarpal bone or the metacarpal bone of the thumb is the first bone of the thumb. It is connected to the trapezium of the carpus at the first carpometacarpal joint and to the proximal thumb phalanx at the first metacarpophalangeal joint[Wikipedia:First_metacarpal_bone]." ; obo:UBPROP_0000104 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010616", "EMAPA:19112", "FMA:23899", "MA:0001364", "NCIT:C52796", "SCTID:181973009", "UMLS:C1708987" ; oboInOwl:hasExactSynonym "finger 1 metacarpus", "first digit of hand metacarpal", "first digit of hand metacarpal bone", "first metacarpal bone", "hand digit 1 metacarpal", "hand digit 1 metacarpal bone", "manual digit 1 metacarpus", "metacarpal 1", "metacarpal I", "metacarpal bone digit 1", "metacarpal bone of digit I", "metacarpal bone of first digit of hand", "metacarpal bone of hand digit 1", "metacarpal bone of thumb", "metacarpal of first digit of hand", "metacarpal of hand digit 1", "metacarpal of thumb", "thumb metacarpal", "thumb metacarpal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forelimb digit 1 metacarpus" ; oboInOwl:id "UBERON:0003645" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metacarpal bone of digit 1" ; rdfs:subClassOf obo:UBERON_0013581, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010570 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015043 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003646 obo:IAO_0000115 "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 2." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with the prepollex and carpal 2(1) or carpal 2+3(1+2) proximally and with the proximal phalanx of digit II(I) distally.[AAO]" ; obo:UBPROP_0000104 "2"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000853", "EMAPA:19114", "FMA:23900", "MA:0001365", "NCIT:C52795", "SCTID:263399007", "UMLS:C1708988" ; oboInOwl:hasExactSynonym "2 nd digit of hand metacarpal", "2 nd digit of hand metacarpal bone", "2 nd finger metacarpal", "2 nd finger metacarpal bone", "finger 2 metacarpus", "hand digit 2 metacarpal", "hand digit 2 metacarpal bone", "manual digit 2 metacarpus", "metacarpal 2", "metacarpal II", "metacarpal bone digit 2", "metacarpal bone of 2 nd digit of hand", "metacarpal bone of 2 nd finger", "metacarpal bone of digit II", "metacarpal bone of hand digit 2", "metacarpal bone of second finger", "metacarpal of 2 nd digit of hand", "metacarpal of 2 nd finger", "metacarpal of hand digit 2", "metacarpal of second finger", "second finger metacarpal", "second finger metacarpal bone", "second metacarpal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forelimb digit 2 metacarpus" ; oboInOwl:id "UBERON:0003646" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metacarpal bone of digit 2" ; rdfs:subClassOf obo:UBERON_0013582, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010571 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015044 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003647 obo:IAO_0000115 "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 3[Automatically generated definition]." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with carpal 3(2) proximally and with the proximal phalanx of digit III(II) distally.[AAO]", "The third metacarpal bone (metacarpal bone of the middle finger) is a little smaller than the second. The dorsal aspect of its base presents on its radial side a pyramidal eminence, the styloid process, which extends upward behind the capitate; immediately distal to this is a rough surface for the attachment of the extensor carpi radialis brevis muscle. The carpal articular facet is concave behind, flat in front, and articulates with the capitate. On the radial side is a smooth, concave facet for articulation with the second metacarpal, and on the ulnar side two small oval facets for the fourth metacarpal[Wikipedia:Third_metacarpal_bone]." ; obo:UBPROP_0000104 "3"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000854", "EMAPA:19116", "FMA:23901", "MA:0001366", "NCIT:C52794", "SCTID:263400000", "UMLS:C1708989", "Wikipedia:Third_metacarpal_bone" ; oboInOwl:hasExactSynonym "3 rd digit of hand metacarpal", "3 rd digit of hand metacarpal bone", "3 rd finger metacarpal", "3 rd finger metacarpal bone", "finger 3 metacarpus", "hand digit 3 metacarpal", "hand digit 3 metacarpal bone", "manual digit 3 metacarpus", "metacarpal 3", "metacarpal III", "metacarpal bone digit 3", "metacarpal bone of 3 rd digit of hand", "metacarpal bone of 3 rd finger", "metacarpal bone of digit III", "metacarpal bone of hand digit 3", "metacarpal bone of third finger", "metacarpal of 3 rd digit of hand", "metacarpal of 3 rd finger", "metacarpal of hand digit 3", "metacarpal of third finger", "third finger metacarpal", "third finger metacarpal bone", "third metacarpal bone" ; oboInOwl:hasNarrowSynonym "forelimb cannon bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forelimb digit 3 metacarpus" ; oboInOwl:id "UBERON:0003647" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metacarpal bone of digit 3" ; rdfs:subClassOf obo:UBERON_0013583, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010572 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015045 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003648 obo:IAO_0000115 "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 4." ; obo:UBPROP_0000001 "The fourth metacarpal bone (metacarpal bone of the ring finger) is shorter and smaller than the third. The base is small and quadrilateral; its superior surface presents two facets, a large one medially for articulation with the hamate, and a small one laterally for the capitate. On the radial side are two oval facets, for articulation with the third metacarpal; and on the ulnar side a single concave facet, for the fifth metacarpal[Wikipedia:Fourth_metacarpal_bone]." ; obo:UBPROP_0000104 "4"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010615", "EMAPA:19118", "FMA:23902", "MA:0001367", "NCIT:C52793", "SCTID:263401001", "UMLS:C1708990" ; oboInOwl:hasExactSynonym "4 th digit of hand metacarpal", "4 th digit of hand metacarpal bone", "4 th finger metacarpal", "4 th finger metacarpal bone", "finger 4 metacarpus", "fourth finger metacarpal", "fourth finger metacarpal bone", "fourth metacarpal bone", "hand digit 4 metacarpal", "hand digit 4 metacarpal bone", "manual digit 4 metacarpus", "metacarpal 4", "metacarpal IV", "metacarpal bone digit 4", "metacarpal bone of 4 th digit of hand", "metacarpal bone of 4 th finger", "metacarpal bone of digit IV", "metacarpal bone of fourth finger", "metacarpal bone of hand digit 4", "metacarpal of 4 th digit of hand", "metacarpal of 4 th finger", "metacarpal of fourth finger", "metacarpal of hand digit 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forelimb digit 4 metacarpus" ; oboInOwl:id "UBERON:0003648" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metacarpal bone of digit 4" ; rdfs:subClassOf obo:UBERON_0013584, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010573 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015046 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003649 obo:IAO_0000115 "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 5." ; obo:UBPROP_0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that articulates with carpal 5(4) proximally and with the proximal phalanx of digit V(IV) distally.[AAO]", "The fifth metacarpal bone (metacarpal bone of the little finger or pinky finger) is the most lateral metacarpal[Wikipedia:Fifth_metacarpal_bone]." ; obo:UBPROP_0000012 "FMA also has FMA:36782 ! Bone of fifth metacarpal bone" ; obo:UBPROP_0000104 "5"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000855", "EMAPA:19120", "FMA:23903", "MA:0001368", "NCIT:C52792", "SCTID:263402008", "UMLS:C1711224" ; oboInOwl:hasExactSynonym "5 th digit of hand metacarpal", "5 th digit of hand metacarpal bone", "5 th finger metacarpal", "5 th finger metacarpal bone", "fifth finger metacarpal", "fifth finger metacarpal bone", "fifth metacarpal bone", "finger 5 metacarpus", "hand digit 5 metacarpal", "hand digit 5 metacarpal bone", "manual digit 5 metacarpus", "metacarpal 5", "metacarpal V", "metacarpal bone digit 5", "metacarpal bone of 5 th digit of hand", "metacarpal bone of 5 th finger", "metacarpal bone of digit V", "metacarpal bone of fifth finger", "metacarpal bone of hand digit 5", "metacarpal of 5 th digit of hand", "metacarpal of 5 th finger", "metacarpal of fifth finger", "metacarpal of hand digit 5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forelimb digit 5 metacarpus" ; oboInOwl:id "UBERON:0003649" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metacarpal bone of digit 5" ; rdfs:subClassOf obo:UBERON_0013585, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010574 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015047 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003650 obo:IAO_0000115 "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 1." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with the prepollex and tarsal 1 proximally and with the proximal phalanx of digit I distally.[AAO]", "The first metatarsal bone is the bone in the body of the foot just behind the big toe. It is remarkable for its great thickness, and is the shortest of the metatarsal bones. The body is strong, and of well-marked prismoid form. The base presents, as a rule, no articular facets on its sides, but occasionally on the lateral side there is an oval facet, by which it articulates with the second metatarsal. Its proximal articular surface is of large size and kidney-shaped; its circumference is grooved, for the tarsometatarsal ligaments, and medially gives insertion to part of the tendon of the Tibialis anterior; its plantar angle presents a rough oval prominence for the insertion of the tendon of the Peronæus longus. The head is large; on its plantar surface are two grooved facets, on which glide sesamoid bones; the facets are separated by a smooth elevation[Wikipedia:First_metatarsal_bone]." ; obo:UBPROP_0000104 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000925", "EMAPA:19123", "FMA:24502", "MA:0001369", "NCIT:C52791", "SCTID:182121005", "UMLS:C1708999" ; oboInOwl:hasExactSynonym "first metatarsal bone", "foot digit 1 metatarsal bone", "hallux metatarsal bone", "metatarsal 1", "metatarsal I", "metatarsal bone digit 1", "metatarsal bone of digit I", "metatarsal bone of foot digit 1", "metatarsal bone of hallux", "toe 1 metatarsal", "toe 1 metatarsus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb digit 1 metatarsus" ; oboInOwl:id "UBERON:0003650" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metatarsal bone of digit 1" ; rdfs:subClassOf obo:UBERON_0013581, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010557 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004332 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015037 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003651 obo:IAO_0000115 "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 2." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 2 proximally and with the proximal phalanx of digit II distally.[AAO]" ; obo:UBPROP_0000104 "2"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000926", "EMAPA:19125", "FMA:24503", "MA:0001370", "NCIT:C52790", "SCTID:182128004", "UMLS:C1709000" ; oboInOwl:hasExactSynonym "foot digit 2 metatarsal bone", "metatarsal 2", "metatarsal II", "metatarsal bone digit 2", "metatarsal bone of digit II", "metatarsal bone of foot digit 2", "second metatarsal bone", "toe 2 metatarsal", "toe 2 metatarsus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb digit 2 metatarsus" ; oboInOwl:id "UBERON:0003651" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metatarsal bone of digit 2" ; rdfs:subClassOf obo:UBERON_0013582, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010558 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015038 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003652 obo:IAO_0000115 "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 3[Automatically generated definition]." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 3 proximally and with the proximal phalanx of digit III distally.[AAO]", "The third metatarsal bone articulates proximally, by means of a triangular smooth surface, with the third cuneiform; medially, by two facets, with the second metatarsal; and laterally, by a single facet, with the fourth metatarsal. This last facet is situated at the dorsal angle of the base[Wikipedia:Third_metatarsal_bone]." ; obo:UBPROP_0000104 "3"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000927", "EMAPA:19127", "FMA:24504", "MA:0001371", "NCIT:C52789", "SCTID:182134006", "UMLS:C1709001", "Wikipedia:Third_metatarsal_bone" ; oboInOwl:hasExactSynonym "foot digit 3 metatarsal bone", "metatarsal 3", "metatarsal III", "metatarsal bone digit 3", "metatarsal bone of digit III", "metatarsal bone of foot digit 3", "third metatarsal bone", "toe 3 metatarsal", "toe 3 metatarsus" ; oboInOwl:hasNarrowSynonym "hindlimb cannon bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb digit 3 metatarsal" ; oboInOwl:id "UBERON:0003652" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metatarsal bone of digit 3" ; rdfs:subClassOf obo:UBERON_0013583, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010559 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015039 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003653 obo:IAO_0000115 "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 4." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 4 or the distal head of the tibiale-fibulare proximally and with the proximal phalanx of digit IV distally.[AAO]", "The fourth metatarsal bone is smaller in size than the third; its base presents an oblique quadrilateral surface for articulation with the cuboid; a smooth facet on the medial side, divided by a ridge into an anterior portion for articulation with the third metatarsal, and a posterior portion for articulation with the third cuneiform; on the lateral side a single facet, for articulation with the fifth metatarsal[Wikipedia:Fourth_metatarsal_bone]." ; obo:UBPROP_0000104 "4"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000928", "EMAPA:19129", "FMA:24505", "MA:0001372", "NCIT:C52788", "SCTID:182139001", "UMLS:C1709002" ; oboInOwl:hasExactSynonym "foot digit 4 metatarsal bone", "fourth metatarsal bone", "metatarsal 4", "metatarsal IV", "metatarsal bone digit 4", "metatarsal bone of digit IV", "metatarsal bone of foot digit 4", "toe 4 metatarsal", "toe 4 metatarsus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb digit 4 metatarsus" ; oboInOwl:id "UBERON:0003653" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metatarsal bone of digit 4" ; rdfs:subClassOf obo:UBERON_0013584, _:genid130003, [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004335 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015040 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003654 obo:IAO_0000115 "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 5." ; obo:UBPROP_0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 5 or the distal head of the tibiale-fibulare proximally and with the proximal phalanx of digit V distally.[AAO]", "The fifth metatarsal bone is recognized by a rough eminence, the tuberosity, on the lateral side of its base. The base articulates behind, by a triangular surface cut obliquely in a transverse direction, with the cuboid; and medially, with the fourth metatarsal. On the medial part of its dorsal surface is inserted the tendon of the Peronæus tertius and on the dorsal surface of the tuberosity that of the Peronæus brevis. A strong band of the plantar aponeurosis connects the projecting part of the tuberosity with the lateral process of the tuberosity of the calcaneus. The plantar surface of the base is grooved for the tendon of the Abductor digiti quinti, and gives origin to the Flexor digiti quinti brevis. The base of the metatarsal is often injured and a particularly notorious fracture is the Jones fracture. When the tuberosity is broken, it is called a pseudo-Jones fracture or a dancer's fracture. This is a common fracture of the fifth metatarsal. Stress fractures are common in the fifth metatarsal among athletes[Wikipedia:Fifth_metatarsal_bone]." ; obo:UBPROP_0000104 "5"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0000929", "EMAPA:19131", "FMA:24506", "MA:0001373", "NCIT:C52787", "SCTID:182144008", "UMLS:C1709003" ; oboInOwl:hasExactSynonym "fifth metatarsal bone", "foot digit 5 metatarsal bone", "metatarsal 5", "metatarsal V", "metatarsal bone digit 5", "metatarsal bone of digit V", "metatarsal bone of foot digit 5", "toe 5 metatarsal", "toe 5 metatarsus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb digit 5 metatarsus" ; oboInOwl:id "UBERON:0003654" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "metatarsal bone of digit 5" ; rdfs:subClassOf obo:UBERON_0013585, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010561 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004336 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015041 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0003655 obo:IAO_0000115 "Molars are the rearmost and most complicated kind of tooth in most mammals." ; obo:UBPROP_0000008 "Adult humans have twelve molars, in four groups of three at the back of the mouth. The third, rearmost molar in each group is called a wisdom tooth. It is the last tooth to appear, breaking through the surface of the gum at about the age of twenty, although this varies from individual to individual. Ethnicity can also have an impact on the age at which this occurs, with statistical variations between groups. The human mouth contains upper (maxillary) and lower (mandibular) molars. They are: maxillary first molar, maxillary second molar, maxillary third molar, mandibular first molar, mandibular second molar, and mandibular third molar." ; oboInOwl:hasDbXref "BTO:0001759", "CALOHA:TS-0637", "EMAPA:32897", "FMA:55638", "MA:0000350", "MESH:D008963", "NCIT:C33136", "SCTID:362115002", "UMLS:C0026367", "Wikipedia:Molar_(tooth)" ; oboInOwl:hasExactSynonym "dens molaris", "molaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "molar" ; oboInOwl:id "UBERON:0003655" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "molar tooth" ; rdfs:subClassOf obo:UBERON_0013164 ; owl:disjointWith obo:UBERON_0003674, obo:UBERON_0007120 . obo:UBERON_0003656 obo:IAO_0000115 "A bone that is part of a mesopodial skeleton." ; obo:UBPROP_0000008 "The carpus (wrist) and tarsus (ankle) of land vertebrates primitively had three rows of carpal or tarsal bones. Often some of these have become lost or fused in evolution. Three proximals. In the hand humans has all three. In the foot the middle proximal appears in 5-15% of people as an os trigonum. Centrale or os centrale, on the medial side. In humans and our closest relatives the African apes (chimpanzees and gorillas) it fuses to the scaphoid where it forms the articulation with the trapezoid bone; occasionally it stays separate. In Man's foot it is the navicular. Some early land vertebrates had more than one (up to three) os centrale per hand or foot. Distals, one per finger / toe at the base of each metacarpal or metatarsal. In mammals the 4th and 5th fuse. In the horse the 1st is lost" ; oboInOwl:hasDbXref "EMAPA:36579", "MA:0000295", "Wikipedia:Carpus_and_tarsus_of_land_vertebrates" ; oboInOwl:hasExactSynonym "basipodium bone", "carpal/tarsal bone", "mesopod bone", "mesopodial bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003656" ; a owl:Class ; rdfs:label "mesopodium bone" ; rdfs:subClassOf obo:UBERON_0013630, _:genid131128 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006716 ] ) ] . obo:UBERON_0003657 obo:IAO_0000115 "Any joint that is part of a (free) limb." ; oboInOwl:hasDbXref "EMAPA:36501", "FMA:321558", "MA:0000691", "SCTID:312683002", "galen:LimbJoint" ; oboInOwl:hasExactSynonym "joint of limb", "joint of limb skeletal system", "skeletal limb joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003657" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses" ; rdfs:label "limb joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003658 obo:IAO_0000115 "Any muscle organ that is part of a hip [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000657" ; oboInOwl:hasExactSynonym "hip muscle organ", "hip region muscle organ", "muscle organ of hip", "muscle organ of hip region", "muscle organ of regio coxae", "regio coxae muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003658" ; a owl:Class ; rdfs:label "hip muscle" ; rdfs:subClassOf _:genid131145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 ] ) ] . obo:UBERON_0003659 obo:IAO_0000115 "Any muscle organ that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37333", "MA:0000648" ; oboInOwl:hasExactSynonym "digit of foot muscle organ", "digit of terminal segment of free lower limb muscle organ", "digitus pedis muscle organ", "foot digit muscle", "foot digit muscle organ", "hind limb digit muscle", "muscle organ of digit of foot", "muscle organ of digit of terminal segment of free lower limb", "muscle organ of digitus pedis", "muscle organ of foot digit", "muscle organ of terminal segment of free lower limb digit", "muscle organ of toe", "terminal segment of free lower limb digit muscle organ", "toe muscle organ" ; oboInOwl:hasNarrowSynonym "foot digit muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003659" ; a owl:Class ; rdfs:label "pedal digit muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003660 obo:IAO_0000115 "A muscle that attaches to an eyelid." ; obo:UBPROP_0000001 "The muscle in the orbit of the eye that lifts the upper eyelid[ncithesaurus:Eyelid_Muscle]." ; oboInOwl:hasDbXref "MA:0000269", "NCIT:C52803", "UMLS:C1707990" ; oboInOwl:hasExactSynonym "blepharon muscle organ", "eyelid muscle organ", "muscle organ of blepharon", "muscle organ of eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003660" ; a owl:Class ; rdfs:label "eyelid muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0003661 obo:IAO_0000115 "Any muscle organ that is part of a limb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32700", "MA:0000692" ; oboInOwl:hasExactSynonym "limb muscle organ", "limb skeletal muscle", "muscle organ of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003661" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "limb muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001015 ], _:genid131190, _:genid131193 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0003662 obo:IAO_0000115 "Any muscle organ that is part of a forelimb." ; obo:UBPROP_0000012 "FMA and MA class actually refer to muscles of entire pectoral complex" ; oboInOwl:hasAlternativeId "UBERON:0005634" ; oboInOwl:hasDbXref "AAO:0000204", "BTO:0000479", "EMAPA:36049", "FMA:37348" ; oboInOwl:hasExactSynonym "fore limb muscle organ", "forelimb muscle organ", "free upper limb muscle", "muscle of free upper limb", "muscle of upper limb", "upper limb skeletal muscle" ; oboInOwl:hasNarrowSynonym "wing muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm muscle system", "musculature of arm", "musculature of the arm" ; oboInOwl:id "UBERON:0003662" ; a owl:Class ; rdfs:label "forelimb muscle" ; rdfs:subClassOf _:genid131203 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003663 obo:IAO_0000115 "Any muscle organ that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "AAO:0000222", "EFO:0001928", "FMA:37368" ; oboInOwl:hasExactSynonym "free lower limb muscle", "hind limb muscle organ", "hindlimb muscle organ", "inferior member muscle organ", "lower extremity muscle organ", "lower limb skeletal muscle", "muscle of free lower limb", "muscle of posterior limb", "muscle organ of hind limb", "muscle organ of hindlimb", "muscle organ of inferior member", "muscle organ of lower extremity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003663" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "hindlimb muscle" ; rdfs:subClassOf _:genid131221 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003664 obo:IAO_0000115 "Any muscle organ that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37331", "MA:0000624" ; oboInOwl:hasExactSynonym "digit of hand muscle organ", "digit of terminal segment of free upper limb muscle organ", "digitus manus muscle organ", "finger muscle organ", "fore limb digit muscle", "hand digit muscle", "hand digit muscle organ", "muscle organ of digit of hand", "muscle organ of digit of terminal segment of free upper limb", "muscle organ of digitus manus", "muscle organ of finger", "muscle organ of hand digit", "muscle organ of terminal segment of free upper limb digit", "terminal segment of free upper limb digit muscle organ" ; oboInOwl:hasNarrowSynonym "hand digit muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003664" ; a owl:Class ; rdfs:label "manual digit muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003665 obo:IAO_0000115 "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." ; obo:UBPROP_0000012 "the BTO class may possibly refer to an invertebrate structure" ; oboInOwl:hasDbXref "AAO:0000081", "BTO:0001905", "EMAPA:37759", "MA:0000699", "SCTID:113230005" ; oboInOwl:hasExactSynonym "caudal muscle", "muscle organ of post-vent region", "muscle organ of tail", "post-vent region muscle organ", "tail muscle", "tail muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003665" ; a owl:Class ; rdfs:label "post-anal tail muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0007812 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001095 ] ) ] . obo:UBERON_0003666 obo:IAO_0000115 "A molar tooth that is part of a upper jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002125", "EHDAA:8053", "EMAPA:17942", "FMA:55720", "MA:0001603", "NCIT:C49795", "UMLS:C1710580" ; oboInOwl:hasExactSynonym "molar tooth of upper jaw", "upper jaw molar tooth", "upper molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillary secondary molar tooth", "upper molar", "upper permanent molar tooth", "upper secondary molar tooth" ; oboInOwl:id "UBERON:0003666" ; a owl:Class ; rdfs:label "upper jaw molar" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002397 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003655 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0003667 obo:IAO_0000115 "A molar tooth that is part of a lower jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001025", "EHDAA:8017", "EMAPA:17921", "FMA:290267", "MA:0001602", "NCIT:C49584", "UMLS:C1708756" ; oboInOwl:hasExactSynonym "lower jaw molar tooth", "lower molar tooth", "molar tooth of lower jaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower molar" ; oboInOwl:id "UBERON:0003667" ; a owl:Class ; rdfs:label "lower jaw molar" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004742 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003655 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0003672 obo:IAO_0000115 "A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl." ; obo:UBPROP_0000001 "Dentition refers to set of teeth, especially with regard to their number, kind, and arrangement, in the mouth.[AAO]", "The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. (MeSH[ncithesaurus:Dentition])" ; obo:UBPROP_0000012 "In FMA this is an anatomical set" ; oboInOwl:hasDbXref "AAO:0000126", "FMA:75150", "GAID:1249", "MESH:D003817", "NCIT:C13072", "SCTID:245543004", "UMLS:C0011443" ; oboInOwl:hasExactSynonym "dentes", "set of teeth", "teeth", "teeth set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "collection of teeth", "teeth" ; oboInOwl:id "UBERON:0003672" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dentition" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034925 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0001091 ] ) ] . obo:UBERON_0003674 obo:IAO_0000115 "A tooth that is typically long and pointed and bearing a single cusp." ; obo:RO_0002161 obo:NCBITaxon_337687 ; obo:UBPROP_0000008 "Most species that develop them normally have four per individual, two in the upper jaw and two in the lower, separated within each jaw by its incisors; humans and dogs are examples. In most animals, canines are the anterior-most teeth in the maxillary bone. The four canines in humans are the two maxillary canines and the two mandibular canines." ; oboInOwl:hasBroadSynonym "canine" ; oboInOwl:hasDbXref "FMA:55636", "GAID:1262", "MESH:D003481", "NCIT:C32258", "SCTID:420817000", "SCTID:88719004", "UMLS:C0010482", "Wikipedia:Canine_tooth" ; oboInOwl:hasExactSynonym "canine tooth", "cuspis dentis" ; oboInOwl:hasNarrowSynonym "caniniform tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canine (tooth)", "canine eminence", "canine teeth", "dens caninus", "dentes canini", "dogtooth (anatomy)", "eye teeth", "eye tooth", "eyeteeth", "eyetooth", "fang" ; oboInOwl:id "UBERON:0003674" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cuspid" ; rdfs:subClassOf _:genid131313 ; owl:disjointWith obo:UBERON_0007120 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0005021 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/57/Azawakh_K9.jpg"^^xsd:anyURI . obo:UBERON_0003675 obo:IAO_0000115 "The portion of the tooth covered by enamel." ; oboInOwl:hasDbXref "FMA:55623", "GAID:1275", "MESH:D019228", "NCIT:C32375", "SCTID:362106009", "UMLS:C0226993" ; oboInOwl:hasExactSynonym "anatomical crown", "corona dentis", "crown of tooth", "tooth crown" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crown" ; oboInOwl:id "UBERON:0003675" ; a owl:Class ; rdfs:label "tooth crown" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001091 ] . obo:UBERON_0003677 obo:IAO_0000115 "The part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone." ; oboInOwl:hasDbXref "EMAPA:37975", "FMA:55624", "GAID:1280", "MESH:D014092", "SCTID:245728004" ; oboInOwl:hasExactSynonym "radix corona", "root of tooth", "tooth root" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003677" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tooth root" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001091 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001091 ] . obo:UBERON_0003679 obo:IAO_0000115 "The ventral area of the mouth. In organisms with a tongue, this is the area under the ventral surface of the tongue[ncit, modified]." ; obo:IAO_0000116 "reclassify after CARO2 overhaul" ; oboInOwl:hasDbXref "CALOHA:TS-2207", "EFO:0001923", "EMAPA:37911", "FMA:86592", "GAID:1283", "MESH:D009060", "NCIT:C54187", "SCTID:245786002", "UMLS:C0026638" ; oboInOwl:hasExactSynonym "floor of mouth", "floor of oval cavity", "floor of the oval cavity" ; oboInOwl:hasNarrowSynonym "sublingual region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003679" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "mouth floor" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] . obo:UBERON_0003681 obo:IAO_0000115 "In humans: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)." ; obo:IAO_0000232 "we use this specifically for a jaw muscle that is innervates by the mandibular nerve." ; obo:UBPROP_0000011 "originate from the somitomeres. These muscles develop late and are not complete even at birth. Tongue muscles develop before masticatory muscles and complete by birth" ; oboInOwl:hasDbXref "FMA:74060", "GAID:145", "MA:0003115", "MESH:D008410", "NCIT:C33147", "SCTID:244769003", "UMLS:C0024890", "Wikipedia:Muscles_of_mastication" ; oboInOwl:hasExactSynonym "muscle of mastication" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "jaw muscle", "musculi masticatorii" ; oboInOwl:id "UBERON:0003681" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "masticatory muscle" ; rdfs:subClassOf obo:UBERON_0011648, _:genid131351, _:genid131353, _:genid131355 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png"^^xsd:anyURI . obo:UBERON_0003682 obo:IAO_0000115 "The muscles of the palate are the glossopalatine, palatoglossus, levator palati(ni), musculus uvulae, palatopharyngeus, and tensor palati(ni)." ; obo:IAO_0000116 "consider extra class for fauces" ; obo:UBPROP_0000012 "see also FMA:71438 ! set of muscles of soft palate and fauces" ; oboInOwl:hasDbXref "EMAPA:37929", "FMA:46726", "GAID:151", "MESH:D010156", "NCIT:C33247", "SCTID:244794002", "SCTID:73711005", "UMLS:C0030213", "Wikipedia:Muscles_of_soft_palate_and_fauces" ; oboInOwl:hasExactSynonym "muscle of palate", "musculi palati mollis et faucium", "palatal muscle", "palate muscle", "palatine muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculi palati mollis et faucium" ; oboInOwl:id "UBERON:0003682" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "palatal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray1028.png"^^xsd:anyURI . obo:UBERON_0003684 obo:IAO_0000115 "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." ; obo:UBPROP_0000012 "in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity" ; oboInOwl:hasDbXref "EFO:0000213", "EMAPA:36505", "FMA:12266", "GAID:17", "MA:0003057", "MESH:D034841", "NCIT:C12664", "SCTID:361294009", "UMLS:C0230168", "Wikipedia:Abdominal_cavity", "galen:AbdominalCavity" ; oboInOwl:hasExactSynonym "cavity of abdominal compartment", "cavity of compartment of abdomen", "space of abdominal compartment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas abdominis" ; oboInOwl:id "UBERON:0003684" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "abdominal cavity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035819 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg"^^xsd:anyURI . obo:UBERON_0003685 obo:IAO_0000115 "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." ; obo:UBPROP_0000202 obo:FMA_71385 ; oboInOwl:hasBroadSynonym "sutura", "suture" ; oboInOwl:hasDbXref "EMAPA:35263", "FMA:7493", "GAID:211", "MA:0001475", "MESH:D003393", "SCTID:244509003", "Wikipedia:Suture_(joint)" ; oboInOwl:hasExactSynonym "cranium suture", "suture joint of skull", "suture of cranium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003685" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cranial suture" ; rdfs:subClassOf obo:UBERON_0009198, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003128 ], _:genid131393 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] . obo:UBERON_0003687 obo:IAO_0000115 "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." ; obo:UBPROP_0000001 "Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO]" ; oboInOwl:hasDbXref "AAO:0010826", "EMAPA:37868", "FMA:75306", "GAID:228", "MESH:D005539", "NCIT:C12495", "SCTID:244679008", "TAO:0002045", "UMLS:C0016519", "Wikipedia:Foramen_magnum", "ZFA:0005387" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003687" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Design pattern notes: check whether this fits the foramen design pattern" ; rdfs:label "foramen magnum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001676 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001896 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png"^^xsd:anyURI . obo:UBERON_0003689 obo:IAO_0000115 "The sella turcica is a saddle-shaped depression in the sphenoid bone at the base of the human skull. [WP,unvetted]." ; obo:IAO_0000116 "for consistency with FMA we have a separate class for the cavity of the sella turcica" ; oboInOwl:hasDbXref "CALOHA:TS-2342", "FMA:54709", "GAID:231", "MESH:D012658", "NCIT:C12497", "SCTID:368554001", "UMLS:C0036609", "Wikipedia:Sella_turcica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Turkey Chair", "suprasellar", "turkish saddle" ; oboInOwl:id "UBERON:0003689" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sella turcica" ; rdfs:subClassOf obo:UBERON_0005913, _:genid131410 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png"^^xsd:anyURI . obo:UBERON_0003690 obo:IAO_0000115 "A collection of sacral vertebrae in the sacral region that are fused and part of the bony pelvis." ; obo:UBPROP_0000007 "sacral" ; obo:UBPROP_0000012 "the AAO class 'sacrum' is deliberately placed under 'sacral vertebra' rather than here" ; oboInOwl:hasDbXref "CALOHA:TS-2201", "EFO:0003071", "FMA:16202", "GAID:241", "MESH:D012447", "NCIT:C33508", "SCTID:264186006", "Wikipedia:Sacrum", "galen:Sacrum" ; oboInOwl:hasExactSynonym "os sacrum [vertebrae sacrales I - V]", "sacrum", "sacrum [sacral vertebrae I - V]", "sacrum [sacral vertebrae I-V]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os sacrum", "sacral bone" ; oboInOwl:id "UBERON:0003690" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "fused sacrum" ; rdfs:subClassOf obo:UBERON_0008001, _:genid131424 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001270 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001094 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray95.png"^^xsd:anyURI . obo:UBERON_0003691 obo:IAO_0000115 "The outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater." ; obo:UBPROP_0000007 "epidural", "extradural" ; obo:UBPROP_0000008 "In humans the epidural space contains lymphatics, spinal nerve roots, loose fatty tissue, small arteries, and a network of large, thin-walled blood vessels called the epidural venous plexus" ; obo:UBPROP_0000012 "in the FMA this is treated as a space of the head, but this ontology covers non-humans, where the space may continue into the tail" ; oboInOwl:hasDbXref "FMA:71228", "GAID:243", "MESH:D004824", "SCTID:281866004", "Wikipedia:Epidural_space" ; oboInOwl:hasExactSynonym "cavum epidurale", "cavum extradurale", "extradural space", "spatium epidurale", "spatium extradurale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epidural cavity" ; oboInOwl:id "UBERON:0003691" ; a owl:Class ; rdfs:label "epidural space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006692 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0002363 ] ) ] . obo:UBERON_0003692 obo:IAO_0000115 "Any joint connecting the acromonion of the scapula and clavicle." ; obo:UBPROP_0000001 "The gliding joint formed by the outer extremity of the clavicle and the inner margin of the acromion process of the scapula." ; oboInOwl:hasDbXref "FMA:25898", "GAID:249", "MESH:D000173", "NCIT:C32047", "SCTID:182166001", "UMLS:C0001208", "Wikipedia:Acromioclavicular_joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acromioclavicular articulation", "articulatio acromioclavicularis", "scapuloclavicular articulation" ; oboInOwl:id "UBERON:0003692" ; a owl:Class ; rdfs:label "acromioclavicular joint" ; rdfs:subClassOf obo:UBERON_0011108, _:genid131455 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002497 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Gray326.png"^^xsd:anyURI . obo:UBERON_0003693 obo:IAO_0000115 "Anatomical space in the abdominal cavity behind (retro) the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they only have peritoneum on their anterior side." ; obo:UBPROP_0000007 "retroperitoneal" ; oboInOwl:hasDbXref "CALOHA:TS-2337", "EFO:0002806", "FMA:15080", "GAID:25", "MESH:D012187", "NCIT:C12298", "SCTID:243983004", "UMLS:C0035359", "Wikipedia:Retroperitoneal_space" ; oboInOwl:hasExactSynonym "retroperitoneum", "spatium retroperitoneale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003693" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "retroperitoneal space" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003684 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray1126.png"^^xsd:anyURI . obo:UBERON_0003694 obo:IAO_0000115 "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." ; oboInOwl:hasDbXref "FMA:25524", "GAID:250", "MESH:D001268", "NCIT:C32157", "SCTID:361832004", "UMLS:C0004168", "Wikipedia:Atlanto-axial_joint" ; oboInOwl:hasExactSynonym "atlanto axial joint", "atlantoaxial joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio atlantoaxialis", "articulatio atlantoepistrophica", "atlantoaxial", "lateral atlanto-axial joint", "median atlanto-axial joint" ; oboInOwl:id "UBERON:0003694" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "atlanto-axial joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011138 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001093 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png"^^xsd:anyURI . obo:UBERON_0003695 obo:IAO_0000115 "The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted]." ; obo:IAO_0000116 "we follow FMA in making these joints part of digits. We include carpometacarpophalangeal joint as a synonym - these joints connect to the carpometacarpus - this is not necessarily inconsistent with the relationship for this class to metacarpal bone, as the carpometacarpus could be considered to have a metacarpal as part" ; obo:UBPROP_0000202 obo:FMA_71364 ; oboInOwl:hasBroadSynonym "metacarpal joint" ; oboInOwl:hasDbXref "EMAPA:19302", "FMA:35246", "GAID:255", "MA:0000453", "MESH:D008662", "NCIT:C33106", "SCTID:280995004", "SCTID:370651001", "UMLS:C0025525", "Wikipedia:Metacarpophalangeal_joint", "galen:MetacarpoPhalangealJoint" ; oboInOwl:hasExactSynonym "MP joint", "knuckle", "knuckles", "metacarpo-phalangeal joint" ; oboInOwl:hasNarrowSynonym "carpometacarpophalangeal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulationes metacarpophalangeae", "metacarpal phalangeal joint" ; oboInOwl:id "UBERON:0003695" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpophalangeal joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002234 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray337.png"^^xsd:anyURI . obo:UBERON_0003696 obo:IAO_0000115 "The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral." ; obo:IAO_0000116 "we follow FMA in making these joints part of digits" ; oboInOwl:hasDbXref "FMA:35222", "GAID:258", "MESH:D008683", "NCIT:C33108", "SCTID:239747005", "SCTID:302535003", "SCTID:370752004", "UMLS:C0025589", "Wikipedia:Metatarsophalangeal_articulations", "galen:MetatarsoPhalangealJoint" ; oboInOwl:hasExactSynonym "metatarsal-phalangeal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulationes metatarsophalangeae", "metatarsal joint", "metatarsalphalangeal joint", "metatarsophalangeal", "metatarsophalangeal articulation" ; oboInOwl:id "UBERON:0003696" ; a owl:Class ; rdfs:label "metatarsophalangeal joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003867 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray268.png"^^xsd:anyURI . obo:UBERON_0003697 obo:IAO_0000115 "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." ; oboInOwl:hasDbXref "EMAPA:37064", "FMA:10429", "FMA:259054", "GAID:26", "MESH:D034861", "NCIT:C77608", "SCTID:181613000", "UMLS:C0836916", "Wikipedia:Abdominal_wall" ; oboInOwl:hasExactSynonym "paries abdominalis", "wall of abdomen", "wall of abdomen proper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal wall proper", "layers of the abdominal wall", "paries abdominalis" ; oboInOwl:id "UBERON:0003697" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "abdominal wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg"^^xsd:anyURI . obo:UBERON_0003698 obo:IAO_0000115 "A joint of the pes that connects the talus and the calcaneus." ; oboInOwl:hasDbXref "FMA:35198", "GAID:260", "MESH:D013380", "NCIT:C33653", "SCTID:182213007", "UMLS:C0038593", "Wikipedia:Subtalar_joint" ; oboInOwl:hasExactSynonym "articulatio subtalaris", "articulatio talocalcanea", "subtalar joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "talocalcaneal articulation", "talocalcaneal joint" ; oboInOwl:id "UBERON:0003698" ; a owl:Class ; rdfs:label "subtalar joint" ; rdfs:subClassOf obo:UBERON_0008447, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG"^^xsd:anyURI . obo:UBERON_0003699 obo:IAO_0000115 "The firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments." ; obo:UBPROP_0000001 "Medial attachment of the two halves of the pelvic girdle.[AAO]" ; obo:UBPROP_0000008 "In birds, the pubic symphysis is present only in the ostrich, and the two hip bones are usually widely separated, making it easier to lay large eggs - Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 188-192. ISBN 0-03-910284-X." ; oboInOwl:hasDbXref "AAO:0000769", "EMAPA:37940", "FMA:16950", "GAID:267", "MESH:D011631", "NCIT:C33425", "SCTID:182200001", "UMLS:C0034015", "Wikipedia:Pubic_symphysis" ; oboInOwl:hasExactSynonym "symphysis pubis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interpubic articulation", "symphisis pubis", "symphysis pubica", "symphysis pubis" ; oboInOwl:id "UBERON:0003699" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "pubic symphysis" ; rdfs:subClassOf obo:UBERON_0002216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001275 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011091 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001275 ], _:genid131546 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Gray321.png"^^xsd:anyURI . obo:UBERON_0003700 obo:IAO_0000115 "A synovial joint of the jaw that connects the mandible to the temporal bone." ; oboInOwl:hasDbXref "BTO:0003674", "EMAPA:19196", "FMA:54832", "GAID:272", "MA:0002899", "MESH:D013704", "NCIT:C32888", "SCTID:181814009", "UMLS:C0039493", "Wikipedia:Temporomandibular_joint" ; oboInOwl:hasExactSynonym "TMJ", "temperomandibular joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio temporomandibularis", "dentary-squamosal joint", "squamosal-dentary joint", "tempero-mandibular joint", "temporalmandibular joint", "temporomandibular", "temporomandibular articulation", "temporomandibular joint" ; oboInOwl:id "UBERON:0003700" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "There are two TMJs, one on either side, working in unison. The unique feature of the TMJs is the articular disc. The disc is composed of fibrocartilagenous tissue (like the firm and flexible elastic cartilage of the ear) which is positioned between the two bones that form the joint. The TMJs are one of the only synovial joints in the human body with an articular disc, another being the sternoclavicular joint. The disc divides each joint into two. The lower joint compartment formed by the mandible and the articular disc is involved in rotational movement -- this is the initial movement of the jaw when the mouth opens. The upper joint compartment formed by the articular disk and the temporal bone is involved in translational movement -- this is the secondary gliding motion of the jaw as it is opened widely. The part of the mandible which mates to the under-surface of the disc is the condyle and the part of the temporal bone which mates to the upper surface of the disk is the glenoid (or mandibular) fossa[WP]." ; rdfs:label "temporomandibular joint" ; rdfs:subClassOf obo:UBERON_0011171, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011130 ], _:genid131567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001695 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004742 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray309.png"^^xsd:anyURI . obo:UBERON_0003701 obo:IAO_0000115 "The Achilles tendon is a tendon of the posterior leg. It serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone." ; obo:UBPROP_0000008 "reduced in non-human primates" ; obo:UBPROP_0000009 "bipedalism, running" ; obo:UBPROP_0000012 "in FMA this is a ligament, and part of the muscle" ; oboInOwl:hasDbXref "EMAPA:35853", "FMA:51061", "GAID:277", "MA:0002993", "MESH:D000125", "NCIT:C32043", "SCTID:181705009", "UMLS:C0001074", "Wikipedia:Achilles_tendon" ; oboInOwl:hasExactSynonym "Achille's tendon", "Achilles tendon", "Achilles' tendon", "calcaneal tendon", "tendo Achillis", "tendo calcaneus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003701" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "calcaneal tendon" ; rdfs:subClassOf obo:UBERON_0000043, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001383 ], _:genid131587 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001450 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg"^^xsd:anyURI . obo:UBERON_0003702 obo:IAO_0000115 "The passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively." ; obo:UBPROP_0000008 "In most mammals the canal remains open, and the testis can pass from the scrotum to the abdominal cavity. In humans the canal closes after testicular descent[DOI:10.1046/j.1469-7580.2002.00087.x]", "In tammar wallabies, closes between days 50 and 60 pp[DOI:10.1046/j.1469-7580.2002.00087.x]" ; oboInOwl:hasDbXref "BTO:0005576", "EMAPA:37881", "FMA:19928", "GAID:28", "MESH:D007264", "NCIT:C93029", "SCTID:243966008", "UMLS:C0021445", "Wikipedia:Inguinal_canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis inguinalis" ; oboInOwl:id "UBERON:0003702" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "inguinal canal" ; rdfs:subClassOf obo:UBERON_0004111, _:genid131598 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray1227.png"^^xsd:anyURI . obo:UBERON_0003703 obo:IAO_0000115 "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." ; obo:IAO_0000116 "includes all the cystic duct, all the common bile duct and the extrahapetic part of the hepatic duct" ; obo:RO_0002171 obo:UBERON_0002107 ; oboInOwl:hasDbXref "FMA:14678", "GAID:281", "MA:0002659", "MESH:D017734", "NCIT:C32573", "SCTID:276158002", "UMLS:C0206187" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bile duct extrahepatic part", "extrahepatic biliary system" ; oboInOwl:id "UBERON:0003703" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "extrahepatic bile duct" ; rdfs:subClassOf obo:UBERON_0002394 . obo:UBERON_0003704 obo:IAO_0000115 "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." ; obo:IAO_0000116 "includes the hepatic duct of the caudate lobe, and the intra- and inter- lobar bile ducts" ; obo:UBPROP_0000001 "Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO]" ; oboInOwl:hasDbXref "FMA:15766", "GAID:287", "MA:0001630", "MESH:D001653", "NCIT:C12677", "SCTID:362193005", "TAO:0005169", "UMLS:C0005401", "ZFA:0005169" ; oboInOwl:hasExactSynonym "bile duct intrahepatic part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intrahepatic biliary system" ; oboInOwl:id "UBERON:0003704" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "intrahepatic bile duct" ; rdfs:subClassOf obo:UBERON_0002394, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002107 ], _:genid131613 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002394 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0003706 obo:IAO_0000115 "Either of two pairs of folds of mucous membrane projecting into the larynx." ; obo:IAO_0000116 "we follow FMA in modeling this is mucous membrane plus ligament" ; oboInOwl:hasDbXref "BTO:0005084", "EMAPA:19181", "FMA:55457", "GAID:344", "MESH:D014827", "NCIT:C12822", "SCTID:245504003", "UMLS:C0042930" ; oboInOwl:hasExactSynonym "true vocal cord", "vocal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plica vocalis", "vocal band", "vocal chord", "vocal fold" ; oboInOwl:id "UBERON:0003706" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "laryngeal vocal fold" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071625 ], _:genid131620, _:genid131622 . obo:UBERON_0003707 obo:IAO_0000115 "One of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve." ; oboInOwl:hasDbXref "EMAPA:18625", "FMA:3745", "GAID:472", "MA:0003051", "MESH:D012850", "NCIT:C33557", "SCTID:277732004", "UMLS:C0503361", "Wikipedia:Aortic_sinus" ; oboInOwl:hasExactSynonym "Petit sinus", "Petit's sinus", "Valsalva sinus", "aortic sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinus aorta", "sinus aortae", "sinus of Morgagni", "sinus of Otto" ; oboInOwl:id "UBERON:0003707" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sinus of Valsalva" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0010172 ], _:genid131633 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/Gray497.png"^^xsd:anyURI . obo:UBERON_0003709 obo:IAO_0000115 "A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle." ; obo:UBPROP_0000008 "In zebrafish, the circle of vessels comprised of the basal communicating artery (BCA) and posterior communicating segments (PCS) superficially resemble but are not homologous to the human circle of Willis" ; oboInOwl:hasBroadSynonym "arterial circle" ; oboInOwl:hasDbXref "EHDAA2:0000252", "EHDAA:9758", "EMAPA:37829", "FMA:50454", "GAID:486", "MESH:D002941", "SCTID:362047009", "Wikipedia:Circle_of_Willis", "neuronames:1468" ; oboInOwl:hasExactSynonym "arterial circle of Willis", "cerebral arterial circle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Willis circle", "circulus arteriosus cerebri" ; oboInOwl:id "UBERON:0003709" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "circle of Willis" ; rdfs:subClassOf obo:UBERON_0004573, _:genid131646, _:genid131648 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg"^^xsd:anyURI . obo:UBERON_0003711 obo:IAO_0000115 "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." ; oboInOwl:hasDbXref "EHDAA2:0000182", "EHDAA:9868", "FMA:4723", "GAID:529", "MESH:D016121", "NCIT:C32816", "SCTID:181371003", "UMLS:C0006095", "Wikipedia:Brachiocephalic_vein", "galen:BrachiocephalicVein" ; oboInOwl:hasExactSynonym "brachiocephalic venous tree", "innominate vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "innomiate vein", "innominate trunk", "innominate vein", "innominate veins", "vena brachiocephalica", "venae anonyma" ; oboInOwl:id "UBERON:0003711" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "brachiocephalic vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007204 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001585 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png"^^xsd:anyURI . obo:UBERON_0003712 obo:IAO_0000115 "The cavernous sinus (or lateral sellar compartment), within the human head, is a large collection of thin-walled veins creating a cavity bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica." ; obo:UBPROP_0000001 "An irregularly shaped venous space in the dura mater at either side of the sphenoid bone[MESH:A07.231.908.224.334]." ; oboInOwl:hasDbXref "EMAPA:19059", "FMA:50772", "GAID:532", "MESH:D002426", "NCIT:C12690", "SCTID:244402005", "UMLS:C0007473", "Wikipedia:Cavernous_sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavernous", "cavernous sinus syndrome", "cavernous sinuses", "cavernus sinus vein", "parasellar syndrome", "sinus cavernosus" ; oboInOwl:id "UBERON:0003712" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cavernous sinus" ; rdfs:subClassOf obo:UBERON_0005486, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0007160 ] . obo:UBERON_0003713 obo:IAO_0000115 "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." ; oboInOwl:hasDbXref "EMAPA:37226", "FMA:14331", "GAID:541", "MA:0002164", "MESH:D013162", "NCIT:C33608", "SCTID:278029005", "UMLS:C0038001", "Wikipedia:Splenic_vein", "galen:SplenicVein" ; oboInOwl:hasExactSynonym "vena splenica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lienal vein", "vena lienalis" ; oboInOwl:id "UBERON:0003713" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "splenic vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001639 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png"^^xsd:anyURI . obo:UBERON_0003714 obo:IAO_0000115 "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." ; obo:UBPROP_0000001 "One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO]" ; obo:UBPROP_0000012 "FMA definition includes vasculature" ; oboInOwl:hasDbXref "AAO:0000325", "AEO:0000123", "EHDAA2:0003123", "FMA:9642", "GAID:609", "MESH:D009417", "NCIT:C13052", "SCTID:91728009", "UMLS:C0027757" ; oboInOwl:hasExactSynonym "nerve tissue", "nervous tissue", "portion of neural tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003714" ; a owl:Class ; rdfs:label "neural tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ; owl:disjointWith obo:UBERON_0004755 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000125 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000540 ] ) ] . obo:UBERON_0003715 obo:IAO_0000115 "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." ; obo:UBPROP_0000010 "All carry sympathetic fibers except for the pelvic splanchnic nerves, which carry parasympathetic fibers" ; oboInOwl:hasDbXref "BAMS:spn", "EMAPA:37959", "FMA:5883", "GAID:800", "MESH:D013153", "SCTID:264198001", "Wikipedia:Splanchnic_nerves" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "splanchnic nerves", "visceral nerve" ; oboInOwl:id "UBERON:0003715" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "splanchnic nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000013 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000013 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0003716 obo:IAO_0000115 "A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch." ; obo:UBPROP_0000001 "Branch of the vagus nerve that separates from the vagus well postcranially, then continues anteriorly to innervate the larynx[AAO:0010754]." ; oboInOwl:hasBroadSynonym "recurrent nerve" ; oboInOwl:hasDbXref "AAO:0010754", "FMA:6246", "GAID:804", "MESH:D012009", "SCTID:24227007", "VHOG:0001347", "Wikipedia:Recurrent_laryngeal_nerve" ; oboInOwl:hasExactSynonym "nervus laryngeus recurrens", "recurrent laryngeal nerve from vagus nerve", "vagus X nerve recurrent laryngeal branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inferior laryngeal nerve", "ramus recurrens" ; oboInOwl:id "UBERON:0003716" ; a owl:Class ; rdfs:label "recurrent laryngeal nerve" ; rdfs:subClassOf obo:UBERON_0001021, _:genid130601, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001759 ], _:genid131711 . obo:UBERON_0003721 obo:IAO_0000115 "The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue." ; oboInOwl:hasDbXref "BAMS:5lg", "EMAPA:19168", "FMA:53218", "GAID:835", "MA:0001102", "MESH:D008036", "SCTID:280260006", "Wikipedia:Lingual_nerve" ; oboInOwl:hasExactSynonym "lingual branch of trigeminal nerve", "trigeminal V nerve lingual branch", "trigeminal nerve lingual branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003721" ; a owl:Class ; rdfs:label "lingual nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000375 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0003723 obo:IAO_0000115 "The vestibular nerve is one of the two branches of the Vestibulocochlear nerve (the cochlear nerve being the other). It goes to the semicircular canals via the vestibular ganglion. It receives positional information. Axons of the vestibular nerve synapse in the vestibular nucleus on the lateral floor and wall of the fourth ventricle in the pons and medulla. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper part of the outer end of the internal auditory meatus. [WP,unvetted]." ; oboInOwl:hasDbXref "BAMS:vVIIIn", "DHBA:12869", "EHDAA2:0002200", "EHDAA:3749", "EMAPA:17803", "FMA:53401", "GAID:840", "MA:0001111", "MBA:413", "MESH:D014725", "NCIT:C12820", "SCTID:362464003", "UMLS:C0042598", "VHOG:0001181", "Wikipedia:Vestibular_nerve", "neuronames:1389" ; oboInOwl:hasExactSynonym "vestibular root of acoustic nerve", "vestibular root of eighth cranial nerve", "vestibulocochlear VIII nerve vestibular component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus vestibularis", "scarpa ganglion", "scarpa's ganglion", "scarpas ganglion", "vestibulocochlear nerve vestibular root" ; oboInOwl:id "UBERON:0003723" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vestibular nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004681 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001840 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006585 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001648 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0007228 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg"^^xsd:anyURI . obo:UBERON_0003724 obo:IAO_0000115 "A large branch of the brachial plexus supplying various parts of the upper arm (as flexor muscles) and forearm (as the skin)." ; oboInOwl:hasDbXref "FMA:37064", "GAID:844", "MESH:D009138", "SCTID:181019000", "Wikipedia:Musculocutaneous_nerve" ; oboInOwl:hasExactSynonym "casserio's nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus musculocutaneus" ; oboInOwl:id "UBERON:0003724" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "musculocutaneous nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001814 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Nerves_of_the_left_upper_extremity.gif"^^xsd:anyURI . obo:UBERON_0003725 obo:IAO_0000115 "An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle." ; oboInOwl:hasDbXref "BAMS:cep", "FMA:5904", "GAID:847", "MESH:D002572", "SCTID:181107005", "Wikipedia:Cervical_plexus" ; oboInOwl:hasExactSynonym "cervical nerve plexus", "cervical plexus", "plexus cervicalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus cervicalis" ; oboInOwl:id "UBERON:0003725" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical nerve plexus" ; rdfs:subClassOf obo:UBERON_0001813, [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0007811 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Gray784.png"^^xsd:anyURI . obo:UBERON_0003726 obo:IAO_0000115 "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." ; oboInOwl:hasDbXref "FMA:5860", "GAID:857", "MESH:D013900", "SCTID:360498003", "Wikipedia:Thoracic_nerves", "neuronames:1725" ; oboInOwl:hasExactSynonym "nervus thoracis", "thoracic spinal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi thoracici", "pectoral nerve" ; oboInOwl:id "UBERON:0003726" ; a owl:Class ; rdfs:label "thoracic nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001780 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0003038 ] ) ] . obo:UBERON_0003727 obo:IAO_0000115 "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:18227", "FMA:6028", "GAID:858", "MESH:D007367", "NCIT:C32825", "SCTID:279568001", "UMLS:C1285089", "Wikipedia:Intercostal_nerves" ; oboInOwl:hasExactSynonym "anterior ramus of thoracic nerve", "anterior ramus of thoracic spinal nerve", "ramus anterior, nervus thoracicus", "thoracic anterior ramus", "ventral ramus of thoracic spinal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi intercostales" ; oboInOwl:id "UBERON:0003727" ; a owl:Class ; rdfs:label "intercostal nerve" ; rdfs:subClassOf obo:UBERON_0001780 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png"^^xsd:anyURI . obo:UBERON_0003728 obo:IAO_0000115 "The central part of the thoracic cavity enclosed by the left and right pleurae." ; obo:UBPROP_0000007 "mediastinal" ; oboInOwl:hasDbXref "CALOHA:TS-2338", "EFO:0003057", "EMAPA:36001", "FMA:9826", "GAID:94", "MA:0003075", "MESH:D008482", "NCIT:C12748", "SCTID:181217005", "UMLS:C0025066", "Wikipedia:Mediastinum" ; oboInOwl:hasExactSynonym "mediastinal part of chest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003728" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "mediastinum" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002224 ], _:genid131778 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Mediastinum.png"^^xsd:anyURI . obo:UBERON_0003729 obo:IAO_0000115 "A mucous membrane that lines the mouth." ; obo:IAO_0000232 "this is defined as any mucous membrane of the mouth - including palate, lips, uvula, etc. ncit split mouth/oral mucosa into lip and buccal. In future we may split into masticatory/keratinized (gingiva + hard palate) vs lining/non-keratinized (lips, cheeks, floor of mouth, soft palate). FMA distinguishes between mucosa of mouth and region of mouth (the latter including the buccal mucosa)" ; obo:UBPROP_0000001 "the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]." ; oboInOwl:hasDbXref "BTO:0002860", "CALOHA:TS-0716", "EMAPA:26937", "FMA:59660", "GAID:951", "MA:0002794", "MESH:D009061", "NCIT:C77637", "UMLS:C0026639", "Wikipedia:Oral_mucosa" ; oboInOwl:hasExactSynonym "mouth mucosa", "mouth mucous membrane", "mouth organ mucosa", "mucosa of mouth", "mucous membrane of mouth", "oral mucous membrane", "oral part of viscerocranial mucosa", "tunica mucosa oris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "buccal mucosa", "mucosal lining of mouth", "oral mucosa", "tunica mucosa oris" ; oboInOwl:id "UBERON:0003729" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mouth mucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001458 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001007 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ) ] . obo:UBERON_0003820 obo:IAO_0000115 "A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." ; obo:UBPROP_0000009 "AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]" ; oboInOwl:hasDbXref "EMAPA:36141" ; oboInOwl:hasExactSynonym "prostate ductal progenitor", "prostatic bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prostate gland bud", "prostate primordium" ; oboInOwl:id "UBERON:0003820" ; a owl:Class ; rdfs:label "prostate bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004902 ], _:genid131810 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005153 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0003821 obo:IAO_0000115 "A bone of the metapodial skeleton." ; oboInOwl:hasDbXref "EMAPA:37284", "MA:0000301" ; oboInOwl:hasExactSynonym "metacarpal or metatarsal bone", "metacarpal/metatarsal", "metacarpal/metatarsal bone", "metapodi bone", "metapodial bone", "metapodium bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003821" ; a owl:Class ; rdfs:label "metapodium bone" ; rdfs:subClassOf obo:UBERON_0002495, _:genid131820 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009877 ] ) ] . obo:UBERON_0003822 obo:IAO_0000115 "The part of the forelimb between pectoral region and the elbow, corresponding to the humerus." ; obo:UBPROP_0000001 "Segment of the hindleg corresponding to the humerus.[AAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000013 "anatomical usage, the term arm refers specifically to the segment between the shoulder and the elbow, while the segment between the elbow and wrist is the forearm. However, in common, literary, and historical usage, arm refers to the entire upper limb from shoulder to wrist. FMA uses the term Arm for this class, so we place it here. Naming conventions for pod terms under discussion within phenoscape group." ; oboInOwl:hasDbXref "AAO:0000199", "EHDAA2:0002112", "EHDAA:4186", "EHDAA:6234", "EMAPA:17424", "FMA:24890", "MA:0000035", "MESH:D001132", "NCIT:C32141", "SCTID:302538001", "UMLS:C0446516", "VHOG:0000343", "VSAO:0005057", "galen:Arm" ; oboInOwl:hasExactSynonym "brachial region", "brachium", "fore propodium", "forelimb propodium", "forelimb stylopodial element", "forelimb stylopodium", "proximal segment of free upper limb", "regio brachialis", "stylopod of arm", "stylopod of forelimb", "upper arm" ; oboInOwl:hasNarrowSynonym "wing stylopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm" ; oboInOwl:id "UBERON:0003822" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "forelimb stylopod" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0015053 ], _:genid131832 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002472 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003823 obo:IAO_0000115 "The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants." ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; obo:UBPROP_0000007 "sural" ; obo:UBPROP_0000012 "FMA:24979 denotes the middle segment (zeugopod), its placement here is correct. See obo-anatomy archives for discussion" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group. TODO - add distinct term for skeleton and place AAO class here" ; oboInOwl:hasDbXref "EFO:0003051", "EHDAA2:0001030", "EHDAA:5165", "EHDAA:6190", "EMAPA:17496", "FMA:24979", "MA:0000051", "MESH:D007866", "NCIT:C32974", "SCTID:244015008", "UMLS:C1140621", "VHOG:0000348", "VSAO:0005060", "Wikipedia:Forearm", "galen:Leg" ; oboInOwl:hasExactSynonym "crus", "crus of hindlimb", "hind limb middle limb segment", "hind limb zeudopodium", "hind limb zeugopod", "hindlimb epipodium", "hindlimb middle limb segment", "hindlimb zeudopodium", "hindlimb zeugopod", "hindlimb zeugopodium", "intermediate segment of free lower limb", "lower extremity middle limb segment", "lower extremity zeugopod", "lower leg", "middle limb segment of hind limb", "middle limb segment of hindlimb", "shank", "zeugopod of hind limb", "zeugopod of hindlimb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hind epipodium", "leg" ; oboInOwl:id "UBERON:0003823" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "hindlimb zeugopod" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010720 ], _:genid131852 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002471 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003824 obo:IAO_0000115 "A nerve that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37265", "MA:0000562", "MESH:D013900", "SCTID:359876006" ; oboInOwl:hasExactSynonym "nerve of thorax", "thoracic segment nerve", "thorax nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body nerve" ; oboInOwl:id "UBERON:0003824" ; a owl:Class ; rdfs:label "nerve of thoracic segment" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0003825 obo:IAO_0000115 "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37061", "MA:0000528" ; oboInOwl:hasExactSynonym "abdominal segment nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003825" ; a owl:Class ; rdfs:label "nerve of abdominal segment" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003826 obo:IAO_0000115 "A bone that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35893", "MA:0000682" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "femur" ; oboInOwl:id "UBERON:0003826" ; a owl:Class ; rdfs:comment "May be merged into femur. See https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; rdfs:label "upper leg bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0003827 obo:IAO_0000115 "A bone that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37247", "MA:0000559", "SCTID:426649006" ; oboInOwl:hasExactSynonym "bone of thorax", "bone organ of thorax", "thorax bone", "thorax bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body bone" ; oboInOwl:id "UBERON:0003827" ; a owl:Class ; rdfs:label "thoracic segment bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0003828 obo:IAO_0000115 "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37058", "MA:0000525" ; oboInOwl:hasExactSynonym "abdominal segment of trunk bone", "abdominal segment of trunk bone organ", "bone of abdominal segment of trunk", "bone organ of abdominal segment of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003828" ; a owl:Class ; rdfs:label "abdominal segment bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003829 obo:IAO_0000115 "Any muscle tissue that is part of the urethra." ; oboInOwl:hasDbXref "EMAPA:37787", "MA:0002649" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethral muscle layer" ; oboInOwl:id "UBERON:0003829" ; a owl:Class ; rdfs:label "urethra muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005090 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0003830 obo:IAO_0000115 "Any muscle organ that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0000561" ; oboInOwl:hasExactSynonym "muscle organ of thorax", "thorax muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body muscle" ; oboInOwl:id "UBERON:0003830" ; a owl:Class ; rdfs:label "thoracic segment muscle" ; rdfs:subClassOf _:genid131934 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0003831 obo:IAO_0000115 "Any muscle organ that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35733", "MA:0001828" ; oboInOwl:hasExactSynonym "apparatus respiratorius muscle organ", "muscle organ of apparatus respiratorius", "muscle organ of respiratory system", "respiratory system muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003831" ; a owl:Class ; rdfs:label "respiratory system muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0003832 obo:IAO_0000115 "Any muscle organ that is part of a esophagus [Automatically generated definition]." ; obo:IAO_0000116 "merge muscle and muscle layer?" ; oboInOwl:hasDbXref "EMAPA:26983", "MA:0002682", "SCTID:360961009" ; oboInOwl:hasExactSynonym "esophageal muscle", "esophagus muscle organ", "gullet muscle organ", "muscle organ of esophagus", "muscle organ of gullet", "muscle organ of oesophagus", "oesophagus muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003832" ; a owl:Class ; rdfs:label "esophagus muscle" ; rdfs:subClassOf _:genid131953 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0003833 obo:IAO_0000115 "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37060", "MA:0000527" ; oboInOwl:hasExactSynonym "abdominal segment of trunk muscle organ", "muscle organ of abdominal segment of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003833" ; a owl:Class ; rdfs:label "abdominal segment muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003834 obo:IAO_0000115 "A blood vessel that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37238", "MA:0000558" ; oboInOwl:hasExactSynonym "blood vessel of thorax", "thorax blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body blood vessel" ; oboInOwl:id "UBERON:0003834" ; a owl:Class ; rdfs:label "thoracic segment blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0003835 obo:IAO_0000115 "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37057", "MA:0000524" ; oboInOwl:hasExactSynonym "abdominal segment of trunk blood vessel", "blood vessel of abdominal segment of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003835" ; a owl:Class ; rdfs:label "abdominal segment blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003836 obo:IAO_0000115 "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37063", "FMA:264898", "MA:0000530" ; oboInOwl:hasExactSynonym "abdominal segment of trunk skin", "skin of abdominal segment of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003836" ; a owl:Class ; rdfs:label "abdominal segment skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003837 obo:IAO_0000115 "A portion of connective tissue that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37253", "MA:0000560" ; oboInOwl:hasExactSynonym "connective tissue of thorax", "portion of connective tissue of thorax", "textus connectivus of thorax", "thorax connective tissue", "thorax portion of connective tissue", "thorax textus connectivus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body connective tissue" ; oboInOwl:id "UBERON:0003837" ; a owl:Class ; rdfs:label "thoracic segment connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0003838 obo:IAO_0000115 "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37059", "MA:0000526" ; oboInOwl:hasExactSynonym "abdominal segment of trunk connective tissue", "abdominal segment of trunk portion of connective tissue", "abdominal segment of trunk textus connectivus", "connective tissue of abdominal segment of trunk", "portion of connective tissue of abdominal segment of trunk", "textus connectivus of abdominal segment of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003838" ; a owl:Class ; rdfs:label "abdominal segment connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0003839 obo:IAO_0000115 "A limb joint that is part of a forelimb [Automatically generated definition]." ; obo:UBPROP_0000202 obo:FMA_71344 ; oboInOwl:hasDbXref "EMAPA:19204", "MA:0000614" ; oboInOwl:hasExactSynonym "anteriormost limb joint of limb", "anteriormost limb limb joint", "fore limb joint of limb", "fore limb limb joint", "forelimb joint of limb", "forelimb limb joint", "joint of free upper limb", "joint of limb of anteriormost limb", "joint of limb of fore limb", "joint of limb of forelimb", "joint of limb of superior member", "joint of limb of upper extremity", "limb joint of anteriormost limb", "limb joint of fore limb", "limb joint of forelimb", "limb joint of superior member", "limb joint of upper extremity", "superior member joint of limb", "superior member limb joint", "upper extremity joint of limb", "upper extremity limb joint" ; oboInOwl:hasNarrowSynonym "wing joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003839" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "forelimb joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0003840 obo:IAO_0000115 "A limb joint that is part of a hindlimb [Automatically generated definition]." ; obo:UBPROP_0000202 obo:FMA_71348 ; oboInOwl:hasDbXref "EMAPA:32635", "MA:0000662", "SCTID:304573000" ; oboInOwl:hasExactSynonym "hind limb joint of limb", "hind limb limb joint", "hindlimb joint of limb", "hindlimb limb joint", "inferior member joint of limb", "inferior member limb joint", "joint of free lower limb", "joint of limb of hind limb", "joint of limb of hindlimb", "joint of limb of inferior member", "joint of limb of lower extremity", "joint of lower limb", "limb joint of hind limb", "limb joint of hindlimb", "limb joint of inferior member", "limb joint of lower extremity", "lower extremity joint of limb", "lower extremity limb joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003840" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hindlimb joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003841 obo:IAO_0000115 "A limb joint that is part of an autopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35160", "MA:0002715" ; oboInOwl:hasExactSynonym "autopod joint of limb", "autopod limb joint", "distal free limb segment joint of limb", "distal free limb segment limb joint", "joint of limb of autopod", "joint of limb of distal free limb segment", "limb joint of autopod", "limb joint of distal free limb segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "paw joint" ; oboInOwl:id "UBERON:0003841" ; a owl:Class ; rdfs:label "autopod joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] ) ] . obo:UBERON_0003842 obo:IAO_0000115 "An anatomical space that surrounded_by a neural tube." ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0005713" ; oboInOwl:hasDbXref "AAO:0011073", "EHDAA2:0001269", "EHDAA:2889", "EHDAA:914", "EMAPA:16167", "VHOG:0001119", "XAO:0000252" ; oboInOwl:hasExactSynonym "cavity of neural tube", "lumen of neural tube", "neural tube neural lumen" ; oboInOwl:hasNarrowSynonym "prosencoel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "central lumen", "neural lumen", "neurocoel" ; oboInOwl:id "UBERON:0003842" ; a owl:Class ; rdfs:label "neural tube lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001049 ] ) ] . obo:UBERON_0003843 obo:IAO_0000115 "Epithelium that is part of a developing tooth or dental organ." ; obo:IAO_0000116 "see comments for dental organ.", "todo - full developmental relationships" ; obo:UBPROP_0000011 "In the developing molar dentition of the mouse, tooth inductive po- tential resides in the dental epithelium until embryonic day (E)12.5 (3). Thereafter, tooth inductive potential shifts to neural crest-derived dental mesenchyme, which acquires the ability to direct tooth formation in nonodontogenic tissues (3, 4)" ; oboInOwl:hasDbXref "AAO:0011027", "BTO:0001723", "EMAPA:32903", "MA:0003151", "NCIT:C54296", "TAO:0005134", "UMLS:C1709309", "VHOG:0001443", "XAO:0003203", "ZFA:0005134" ; oboInOwl:hasExactSynonym "dental epithelia", "dental epithelium", "odontogenic epithelium", "tooth epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "reduced enamel epithelium" ; oboInOwl:id "UBERON:0003843" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "dental epithelium" ; rdfs:subClassOf _:genid132100 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005176 ] ) ] . obo:UBERON_0003844 obo:IAO_0000115 "An epithelium that is part of an upper eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002116", "EMAPA:17835", "VHOG:0000638" ; oboInOwl:hasExactSynonym "epithelial tissue of superior eyelid", "epithelial tissue of upper eyelid", "epithelium of superior eyelid", "epithelium of upper eyelid", "superior eyelid epithelial tissue", "superior eyelid epithelium", "upper eyelid epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003844" ; a owl:Class ; rdfs:label "upper eyelid epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0003845 obo:IAO_0000115 "An epithelium that is part of a lower eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001016", "EMAPA:17832", "VHOG:0000637" ; oboInOwl:hasExactSynonym "epithelial tissue of inferior eyelid", "epithelial tissue of lower eyelid", "epithelium of inferior eyelid", "epithelium of lower eyelid", "inferior eyelid epithelial tissue", "inferior eyelid epithelium", "lower eyelid epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003845" ; a owl:Class ; rdfs:label "lower eyelid epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0003846 obo:IAO_0000115 "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." ; oboInOwl:hasDbXref "BTO:0001836", "CALOHA:TS-1040", "EHDAA2:0002019", "EMAPA:35864", "MA:0000768", "NCIT:C45713", "UMLS:C1711423", "VHOG:0001426", "ZFA:0005779" ; oboInOwl:hasExactSynonym "epithelial tissue of thymus", "epithelial tissue of thymus gland", "epithelium of thymus", "epithelium of thymus gland", "thymic epithelial tissue", "thymic epithelium", "thymus epithelial tissue", "thymus gland epithelial tissue", "thymus gland epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003846" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thymus epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002293 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002370 ], _:genid132137 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0003847 obo:IAO_0000115 "An artery that supplies a thyroid gland." ; obo:UBPROP_0000001 "Part of the external carotid which supplies blood to the thyroid gland.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of external carotid (AAO:0010218)[AAO]" ; oboInOwl:hasDbXref "AAO:0010490", "EHDAA2:0002029", "EHDAA:7372", "EMAPA:18622", "MA:0002066", "NCIT:C53020", "UMLS:C1711424", "VHOG:0001366" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003847" ; a owl:Class ; rdfs:label "thyroid artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0003848 obo:IAO_0000115 "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." ; oboInOwl:hasDbXref "EHDAA2:0000719", "EHDAA:8703", "SCTID:278192008", "VHOG:0001340", "Wikipedia:Gonadal_vein" ; oboInOwl:hasExactSynonym "gonad vein", "gonada vein", "vein of gonad", "vein of gonada" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003848" ; a owl:Class ; rdfs:label "gonadal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000991 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png"^^xsd:anyURI . obo:UBERON_0003849 obo:IAO_0000115 "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003591", "EHDAA2:0001101", "EHDAA:360", "TAO:0000935", "VHOG:0000796", "ZFA:0000935" ; oboInOwl:hasExactSynonym "mesencephalic neural crest", "neural crest midbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003849" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesencephalic neural crest" ; rdfs:subClassOf obo:UBERON_0003099 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002342 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0003850 obo:IAO_0000115 "A neural crest that has_potential_to_developmentally_contribute_to a telencephalon." ; obo:UBPROP_0000001 "Cranial neural crest that is part of the telencephalon.[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003574", "RETIRED_EHDAA2:0001991", "TAO:0000812", "VHOG:0000799", "ZFA:0000812" ; oboInOwl:hasExactSynonym "neural crest telencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003850" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "telencephalon neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002342 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0003851 obo:IAO_0000115 "A neural crest that has_potential_to_developmentally_contribute_to a diencephalon." ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003573", "EHDAA2:0000603", "EMAPA:16518", "TAO:0000811", "VHOG:0000798", "ZFA:0000811" ; oboInOwl:hasExactSynonym "diencephalic neural crest", "future diencephalon neural crest", "neural crest diencephalon", "neural crest of future diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003851" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "diencephalon neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002342 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0003852 obo:IAO_0000115 "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." ; obo:UBPROP_0000001 "Cranial neural crest that is part of the hindbrain.[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001628", "EHDAA:362", "EMAPA:35747", "TAO:0007063", "VHOG:0001210", "ZFA:0007063" ; oboInOwl:hasExactSynonym "neural crest hindbrain", "rhombencephalic neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombomere neural crest" ; oboInOwl:id "UBERON:0003852" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "rhombencephalon neural crest" ; rdfs:subClassOf obo:UBERON_0003099 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002342 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0003853 obo:IAO_0000115 "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA:696", "EMAPA:16163", "EMAPA:16881", "VHOG:0001006" ; oboInOwl:hasExactSynonym "neural crest spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spinal neural crest" ; oboInOwl:id "UBERON:0003853" ; a owl:Class ; rdfs:label "spinal cord neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002342 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0003854 obo:IAO_0000115 "A neural plate that develops_from a future spinal cord." ; obo:UBPROP_0000001 "Neural plate that is part of the spinal cord. [Bgee_curator][VHOG]" ; obo:UBPROP_0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG]" ; oboInOwl:hasDbXref "FMA:312957", "TAO:0007021", "VHOG:0000439", "ZFA:0007021" ; oboInOwl:hasExactSynonym "neural plate of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003854" ; a owl:Class ; rdfs:label "spinal cord neural plate" ; rdfs:subClassOf _:genid132217 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003075 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006241 ] ) ] . obo:UBERON_0003855 obo:IAO_0000115 "Mesenchyme that is part of a developing gonad [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA:5012", "EMAPA:16858", "EMAPA:17385", "VHOG:0001090" ; oboInOwl:hasExactSynonym "gonada mesenchyme", "mesenchyme of gonad", "mesenchyme of gonada" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003855" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gonad mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000991 ] ) ] . obo:UBERON_0003856 obo:IAO_0000115 "Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla." ; obo:IAO_0000116 "we follow ZFA in introducing an additional distinction between the dental papilla and the (uncondensed) mesenchyme. Note that in some species such as zebrafish teeth are not part of the mouth, and sharks have dermal denticles which share similar developmental origins with teeth. For now we assume a NC origin for all and add a taxon restriction to 1st arch mesenchyme" ; obo:UBPROP_0000001 "Mesenchyme enclosed by dental organ.[MP]", "Mesenchyme enclosed by dental organ.[TAO]" ; oboInOwl:hasDbXref "EMAPA:32891", "MA:0003152", "TAO:0005139", "VHOG_RETIRED:0001444", "ZFA:0005139" ; oboInOwl:hasExactSynonym "dental mesenchyme", "dental organ mesenchyme", "enamel organ mesenchyme", "tooth enamel organ mesenchyme", "tooth mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003856" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "uncondensed odontogenic mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005176 ], _:genid132235 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008281 ] ) ] . obo:UBERON_0003857 obo:IAO_0000115 "Mesenchyme that is part of a developing upper eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002117", "EHDAA:9051", "EMAPA:17836", "VHOG:0001093" ; oboInOwl:hasExactSynonym "mesenchyme of superior eyelid", "mesenchyme of upper eyelid", "superior eyelid mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003857" ; a owl:Class ; rdfs:label "upper eyelid mesenchyme" ; rdfs:subClassOf _:genid132250 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0003858 obo:IAO_0000115 "Mesenchyme that is part of a developing lower eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001017", "EHDAA:9045", "EMAPA:17833", "VHOG:0001036" ; oboInOwl:hasExactSynonym "inferior eyelid mesenchyme", "mesenchyme of inferior eyelid", "mesenchyme of lower eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003858" ; a owl:Class ; rdfs:label "lower eyelid mesenchyme" ; rdfs:subClassOf _:genid132260 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0003859 obo:IAO_0000115 "Mesenchyme that is part of a developing forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32628", "VHOG:0001109" ; oboInOwl:hasExactSynonym "anteriormost limb mesenchyme", "fore limb mesenchyme", "mesenchyme of anteriormost limb", "mesenchyme of fore limb", "mesenchyme of forelimb", "mesenchyme of superior member", "mesenchyme of upper extremity", "superior member mesenchyme", "upper extremity mesenchyme" ; oboInOwl:hasNarrowSynonym "wing mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003859" ; a owl:Class ; rdfs:label "forelimb mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid131145 ) ] . obo:UBERON_0003860 obo:IAO_0000115 "Mesenchyme that is part of a developing hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32637", "VHOG:0001074" ; oboInOwl:hasExactSynonym "hind limb mesenchyme", "inferior member mesenchyme", "lower extremity mesenchyme", "mesenchyme of hind limb", "mesenchyme of hindlimb", "mesenchyme of inferior member", "mesenchyme of lower extremity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003860" ; a owl:Class ; rdfs:label "hindlimb mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0003861 obo:IAO_0000115 "Posterior part of a vertebra that consists of a pair of pedicles and a pair of laminae, and supports seven processes: four articular processes, two transverse processes one spinous process[WP]. ZFA: A neural arch encloses the neural canal and typically meets its partner to form a neural spine." ; obo:UBPROP_0000001 "A neural arch encloses the neural canal and typically meets its partner to form a neural spine. The neural arch can be a replacement ossification of the basidorsal cartilage or can form directly in membrane bone.[TAO]", "Bony arch perched on the vertebral centrum; successive arches enclose the neural canal that surrounds and protects the spinal cord dorsally.[AAO]", "the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" ; obo:UBPROP_0000002 "relationship loss: develops_from basidorsal (TAO:0001060)[TAO]" ; obo:UBPROP_0000003 "(...) certain common components [of vertebral structure] are found in nearly all vertebrate. A representative vertebra has a vertebral arch or neural arch, which extends dorsally around the spinal cord.[well established][VHOG]" ; obo:UBPROP_0000008 "tiny neural arches present in Hagfish (which lack a true vertebraal column)." ; obo:UBPROP_0000011 "The neural arch can be a replacement ossification of the basidorsal cartilage or can form directly in membrane bone" ; oboInOwl:hasBroadSynonym "vertebra neural arch" ; oboInOwl:hasDbXref "AAO:0000725", "EFO:0003618", "FMA:11946", "MA:0001453", "NCIT:C32138", "SCTID:317373001", "TAO:0001066", "UMLS:C0223076", "VHOG:0001670", "Wikipedia:Vertebral_arch", "ZFA:0001066" ; oboInOwl:hasExactSynonym "arcus vertebra", "arcus vertebrae", "arcus vertebrae (vertebralis)", "dorsal arcocentrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcus vertebrae", "vertebra dorsal arch" ; oboInOwl:id "UBERON:0003861" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "neural arch" ; rdfs:subClassOf obo:UBERON_0002513, obo:UBERON_0010358, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006063 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png"^^xsd:anyURI . obo:UBERON_0003862 obo:IAO_0000115 "A phalanx that is part of a foot digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19130", "FMA:32901", "MA:0001384", "NCIT:C52781", "SCTID:361804008", "UMLS:C1708086" ; oboInOwl:hasExactSynonym "digit long bone of foot digit 4", "foot digit 4 digit long bone", "foot digit 4 long bone of digit", "foot digit 4 phalanx", "fourth toe phalanx", "hind limb digit 4 phalanx", "long bone of digit of foot digit 4", "pedal digit IV phalanx", "phalanx of foot digit 4", "phalanx of fourth toe" ; oboInOwl:hasNarrowSynonym "foot digit 4 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003862" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 4 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ], _:genid131190 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0003863 obo:IAO_0000115 "A phalanx that is part of a foot digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19132", "FMA:32902", "MA:0001385", "NCIT:C52782", "SCTID:361806005", "UMLS:C1708088" ; oboInOwl:hasExactSynonym "digit long bone of foot digit 5", "foot digit 5 digit long bone", "foot digit 5 long bone of digit", "foot digit 5 phalanx", "hind limb digit 5 phalanx", "little toe phalanx", "long bone of digit of foot digit 5", "pedal digit V phalanx", "phalanx of fifth digit of foot", "phalanx of fifth toe", "phalanx of foot digit 5", "phalanx of little toe" ; oboInOwl:hasNarrowSynonym "foot digit 5 phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003863" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 5 phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010684 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0003864 obo:IAO_0000115 "A middle phalanx that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37306", "FMA:75817", "MA:0001394", "NCIT:C12863", "SCTID:113223004", "SCTID:371230003", "UMLS:C0223828" ; oboInOwl:hasExactSynonym "hand middle phalanx", "middle manual phalanx", "middle phalanx of finger", "middle phalanx of hand", "middle phalanx of manual digit", "phalanx media manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003864" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of manus" ; rdfs:subClassOf obo:UBERON_0001436, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0001436 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001436 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003865 obo:IAO_0000115 "A distal phalanx that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35393", "FMA:75818", "MA:0001388", "NCIT:C52784", "SCTID:182001007", "SCTID:361782004", "UMLS:C1269782" ; oboInOwl:hasExactSynonym "distal manual phalanx", "distal phalanx of finger", "distal phalanx of hand", "distal phalanx of manual digit", "hand distal phalanx", "phalanx distalis manus", "terminal phalanx of hand", "ungual phalanx of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003865" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "This is typically proximally connected to the middle phalanx of manus, except in some cases such as the manual digit 1 (thumb) of many mammals such as humans, where it connects to the proximal phalanx. It always connects to some phalanx, by definition" ; rdfs:label "distal phalanx of manus" ; rdfs:subClassOf obo:UBERON_0001436, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009552 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001436 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0003866 obo:IAO_0000115 "A middle phalanx that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37311", "FMA:75829", "MA:0001386", "SCTID:83207005" ; oboInOwl:hasExactSynonym "foot middle phalanx", "middle pedal phalanx", "middle phalanx of foot", "middle phalanx of toe", "phalanx media pedis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003866" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of pes" ; rdfs:subClassOf obo:UBERON_0001449, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101466 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0001449 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003867 obo:IAO_0000115 "A distal phalanx that is part of a pedal digit [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37310", "FMA:75830", "MA:0001380", "NCIT:C52783", "SCTID:361797001", "UMLS:C0224026" ; oboInOwl:hasExactSynonym "distal pedal phalanx", "distal phalanx of foot", "distal phalanx of toe", "foot distal phalanx", "phalanx distalis pedis", "terminal phalanx of foot", "terminal phalanx of hindlimb", "ungual phalanx of foot", "ungual phalanx of hindlimb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003867" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "This is typically proximally connected to the middle phalanx of pes, except in some cases such as the pedal digit 1 (big toe) in many mammals such as humans, where it connects to the proximal phalanx. It always connects to some phalanx, by definition" ; rdfs:label "distal phalanx of pes" ; rdfs:subClassOf obo:UBERON_0001449, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009553 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101466 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001449 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003868 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37312", "FMA:75828", "MA:0001387", "NCIT:C52785", "SCTID:85533000", "UMLS:C0224020" ; oboInOwl:hasExactSynonym "foot proximal phalanx", "phalanx proximalis pedis", "proximal pedal phalanx", "proximal phalanx of foot", "proximal phalanx of foot digit", "proximal phalanx of hind digit", "proximal phalanx of pes", "proximal phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003868" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pes" ; rdfs:subClassOf obo:UBERON_0001449, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101466 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001448 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0003869 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a ganglion." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003869" ; a owl:Class ; rdfs:label "presumptive ganglion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000045 ] ) ] . obo:UBERON_0003885 obo:IAO_0000115 "A mesentery that is part of a uterus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35562", "FMA:19816", "MA:0002931", "SCTID:250172001", "Wikipedia:Mesometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesentery of uterus" ; oboInOwl:id "UBERON:0003885" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mesometrium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012332 ], _:genid132426, _:genid132428 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:UBERON_0003886 obo:IAO_0000115 "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." ; oboInOwl:hasExactSynonym "future coelomic cavity lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body cavity precursor" ; oboInOwl:id "UBERON:0003886" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:label "future coelemic cavity lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 ], _:genid131313, [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000111 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002323 ] ) ] . obo:UBERON_0003887 obo:IAO_0000115 "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." ; obo:IAO_0000116 "consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults" ; obo:UBPROP_0000003 "(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA:251", "EMAPA:16088", "NCIT:C34195", "UMLS:C1512940", "VHOG:0000316", "Wikipedia:Intraembryonic_coelom" ; oboInOwl:hasExactSynonym "somatic coelom" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003887" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "intraembryonic coelom" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011997 ], _:genid132442 . obo:UBERON_0003889 obo:IAO_0000115 "Initial section of the oviduct through which the ova pass from the ovary to the uterus." ; obo:UBPROP_0000008 "Homologous to appendix testis" ; oboInOwl:hasBroadSynonym "salpinges", "salpinx" ; oboInOwl:hasDbXref "CALOHA:TS-0732", "EHDAA2:0000504", "EMAPA:18984", "EMAPA:35660", "EV:0100112", "FMA:18245", "GAID:365", "MA:0000385", "MESH:D005187", "NCIT:C12403", "SCTID:181463001", "UMLS:C0015560", "Wikipedia:Fallopian_tube", "galen:FallopianTube" ; oboInOwl:hasExactSynonym "mammalian oviduct", "uterine tube (sensu Mammalia)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fallopian tubes", "female paramesonephric duct", "paramesonephric duct of female", "tuba uterina" ; oboInOwl:id "UBERON:0003889" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "fallopian tube" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000995 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003984 ], _:genid132455 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013515 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003890 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg"^^xsd:anyURI . obo:UBERON_0003890 obo:IAO_0000115 "Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM]." ; obo:UBPROP_0000001 "Either of the paired embryonic ducts developing into the uterine tubes, uterus, and vagina in the female and becoming largely obliterated in the male. [TFD][VHOG]", "Transient developmental organ which gives rise to oviducts in female (documented to persist in some male frogs).[AAO]" ; obo:UBPROP_0000003 "In females, the archinephric (mesonephric) ducts tend to function only within the urinary systems. The muellerian duct arises embryologically next to the archinephric (wolffian) duct. In males, the muellerian duct regresses if it appears at all, but in females, the muellerian ducts become the oviducts of the reproductive system.[well established][VHOG]" ; obo:UBPROP_0000011 "Sertoli cells secrete anti-Mullerian hormone (AMH) inducing the demise of this duct" ; oboInOwl:hasAlternativeId "UBERON:0005318" ; oboInOwl:hasDbXref "AAO:0010141", "EHDAA2:0004048", "EMAPA:27665", "GAID:1309", "MESH:D009095", "NCIT:C13260", "RETIRED_EHDAA2:0001399", "SCTID:308802006", "UMLS:C0026732", "VHOG:0001199", "Wikipedia:Paramesonephric_duct", "XAO:0000330" ; oboInOwl:hasExactSynonym "Muellerian duct", "Müllerian duct", "ductus paramesonephricus", "paramesonephric duct" ; oboInOwl:hasNarrowSynonym "early paramesonephric duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003890" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "Mullerian duct" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid132469 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png"^^xsd:anyURI . obo:UBERON_0003891 obo:IAO_0000115 "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." ; obo:UBPROP_0000007 "stromal" ; oboInOwl:hasDbXref "FMA:81494", "NCIT:C67387", "UMLS:C0927195" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "stromal connective tissue" ; oboInOwl:id "UBERON:0003891" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "stroma" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ] . obo:UBERON_0003893 obo:IAO_0000115 "A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP]." ; obo:UBPROP_0000007 "capsular" ; oboInOwl:hasDbXref "EHDAA:4739", "EHDAA:9061", "FMA:85272", "Wikipedia:Capsule_(anatomy)", "galen:Capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003893" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:comment "see also: protective structure surrounding some species of bacteria and fungi. Note that FMA has classes such as Articular capsule that are not subtypes of Capsule (which is undefined in FMA). GO has 'capsule' which is a fungal structure, and 'external encapsulating structure' which is restricted to cells" ; rdfs:label "capsule" ; rdfs:subClassOf obo:UBERON_0000158, _:genid131353 . obo:UBERON_0003894 obo:IAO_0000115 "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." ; obo:IAO_0000116 "consider adding further subdivisions of the endoderm, e.g. ventral foregut. Note we place two EFO classes here, it's not clear how they differ" ; oboInOwl:hasDbXref "AAO:0011058", "BTO:0003391", "EFO:0002577", "EFO:0003428", "EHDAA2:0000744", "EHDAA:973", "EMAPA:16847", "NCIT:C34277", "TAO:0000124", "UMLS:C0734013", "UMLS:C1514451", "XAO:0003266", "ZFA:0000124" ; oboInOwl:hasExactSynonym "embryological hepatic plate", "primordium of the liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic plate", "liver bud", "liver endoderm" ; oboInOwl:id "UBERON:0003894" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "liver primordium" ; rdfs:subClassOf obo:UBERON_0000485, obo:UBERON_0001048, _:genid132489, _:genid132491 ; owl:equivalentClass _:genid131355 . obo:UBERON_0003895 obo:IAO_0000115 "Portion of myotome that is ventral to the horizontal septum." ; oboInOwl:hasDbXref "TAO:0001085", "ZFA:0001085" ; oboInOwl:hasExactSynonym "hypaxial myotome region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body wall muscle" ; oboInOwl:id "UBERON:0003895" ; a owl:Class ; rdfs:label "hypaxial myotome region" ; rdfs:subClassOf obo:UBERON_0001134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003082 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000102 ; owl:someValuesFrom obo:UBERON_0003901 ] . obo:UBERON_0003897 obo:IAO_0000115 "One of the skeletal muscles of the head and neck, spine, and ribs." ; oboInOwl:hasDbXref "EHDAA:5982", "EMAPA:18167", "MA:0003153", "RETIRED_EHDAA2:0000160", "TAO:0001954" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003897" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "axial muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013700 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002177 ; owl:someValuesFrom obo:UBERON_0005944 ] ) ] . obo:UBERON_0003898 obo:IAO_0000115 "A portion of skeletal muscle tissue in the trunk." ; oboInOwl:hasDbXref "SCTID:244848007" ; oboInOwl:hasExactSynonym "skeletal muscle of torso", "skeletal muscle tissue of torso", "skeletal muscle tissue of trunk", "torso skeletal muscle", "torso skeletal muscle tissue", "trunk skeletal muscle", "trunk skeletal muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003898" ; a owl:Class ; rdfs:label "skeletal muscle tissue of trunk" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013700 ], _:genid132518 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0003900 obo:IAO_0000115 "Portion of myotome that is dorsal to the horizontal septum." ; oboInOwl:hasDbXref "TAO:0001084", "ZFA:0001084" ; oboInOwl:hasExactSynonym "epaxial myotome regions" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003900" ; a owl:Class ; rdfs:label "epaxial myotome region" ; rdfs:subClassOf obo:UBERON_0001134, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003082 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0003901 ] . obo:UBERON_0003901 obo:IAO_0000115 "A logitudinal sheet of continuous connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses; each is destined to become, respectively, the epaxial and hyopaxial musculature." ; obo:UBPROP_0000001 "A connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: subclass myoseptum (TAO:0001089)[TAO]" ; oboInOwl:hasDbXref "EFO:0003555", "TAO:0000671", "ZFA:0000671" ; oboInOwl:hasExactSynonym "horizontal myoseptum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "horizontal septum of vertebra" ; oboInOwl:id "UBERON:0003901" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "horizontal septum" ; rdfs:subClassOf obo:UBERON_0003037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000383 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003895 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003900 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ] . obo:UBERON_0003902 obo:IAO_0000115 "The part of the retina that contains neurons and photoreceptor cells[GO]." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011095", "BTO:0000929", "CALOHA:TS-0685", "EHDAA2:0001253", "EHDAA:4763", "EMAPA:17171", "EMAPA:18590", "FMA:58628", "MA:0000277", "NCIT:C33166", "TAO:0000046", "UMLS:C1518263", "VHOG:0000535", "XAO:0003216", "ZFA:0000046" ; oboInOwl:hasExactSynonym "neural layer of retina", "neural retina", "neuroretina", "stratum nervosum (retina)", "stratum nervosum retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural retinal epithelium" ; oboInOwl:id "UBERON:0003902" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "retinal neural layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000210 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000540 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0005426 ], _:genid132548 ; owl:equivalentClass _:genid131410 . obo:UBERON_0003907 obo:IAO_0000115 "An atrioventricular canal that is in the left side of a atrioventricular region." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000012 "EHDAA2 represents lumen" ; oboInOwl:hasDbXref "EHDAA2:0000935", "EHDAA:5336", "FMA:71123" ; oboInOwl:hasExactSynonym "left AVC", "left atrio-ventricular canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003907" ; a owl:Class ; rdfs:label "left atrioventricular canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002087 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0011820 ] ) ] . obo:UBERON_0003908 obo:IAO_0000115 "An atrioventricular canal that is in the right side of a atrioventricular region." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; obo:UBPROP_0000012 "EHDAA2 represents lumen" ; oboInOwl:hasDbXref "EHDAA2:0001719", "EHDAA:5338", "FMA:71122" ; oboInOwl:hasExactSynonym "right AVC", "right atrio-ventricular canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003908" ; a owl:Class ; rdfs:label "right atrioventricular canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002087 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0011820 ] ) ] . obo:UBERON_0003909 obo:IAO_0000115 "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." ; obo:UBPROP_0000001 "Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO]" ; obo:UBPROP_0000007 "sinusoidal" ; obo:UBPROP_0000012 "some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined)." ; oboInOwl:hasDbXref "FMA:63131", "SCTID:340163004", "TAO:0005261", "Wikipedia:Sinusoid_(blood_vessel)", "ZFA:0005261" ; oboInOwl:hasExactSynonym "sinusoidal blood vessel", "sinusoidal blood vessel endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "endothelium of irregular blood filled space", "sinusoidal capillary", "sinusoidal endothelium" ; oboInOwl:id "UBERON:0003909" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "sinusoid" ; rdfs:subClassOf obo:UBERON_0001982, obo:UBERON_2005260 . obo:UBERON_0003910 obo:IAO_0000115 "Wide vessels in the spleen that drain into trabecular veins[WP]." ; obo:RO_0002161 obo:NCBITaxon_9681, obo:NCBITaxon_9822 ; obo:UBPROP_0000008 "Whereas man and the rat are in the 'sinusal' group, the mouse belongs in the 'nonsinusal' group. The red pulp of spleens of rat, dog, man, and many other mammals contains an elaborate plexus of sinuses; that of mouse, cat, pig and others has no true sinuses and relatively few veins leading from the meshes into collecting veins - http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" ; oboInOwl:hasDbXref "FMA:63199", "SCTID:9081000", "Wikipedia:Red_pulp#Sinusoids" ; oboInOwl:hasExactSynonym "sinusoidal blood vessel of spleen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinusoid of red pulp of spleen" ; oboInOwl:id "UBERON:0003910" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "splenic sinusoid" ; rdfs:subClassOf obo:UBERON_0003909, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001250 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0010400 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003909 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001250 ] ) ] . obo:UBERON_0003911 obo:IAO_0000115 "The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue." ; obo:UBPROP_0000010 "The CP epithelial layer is continuous with the ependymal cell layer that lines the ventricles, but unlike the ependyma, the epithelial layer has tight gap junctions between the cells on the side facing the ventricle (apical surface). These gap junctions prevent the majority of substances from crossing the cell layer into the CSF; thus the CP acts as a blood-CSF barrier" ; oboInOwl:hasDbXref "EMAPA:36608", "FMA:242811", "MA:0000824", "NCIT:C42079", "UMLS:C1516506" ; oboInOwl:hasExactSynonym "choroid plexus epithelial tissue", "epithelial tissue of chorioid plexus of cerebral hemisphere", "epithelial tissue of choroid plexus", "epithelium of choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003911" ; a owl:Class ; rdfs:label "choroid plexus epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:UBERON_0003913 obo:IAO_0000115 "Hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." ; oboInOwl:hasDbXref "HAO:0001019" ; oboInOwl:hasExactSynonym "tooth-like organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003913" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "see dermal denticle" ; rdfs:label "tooth-like structure" ; rdfs:subClassOf obo:UBERON_0004765, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071626 ] . obo:UBERON_0003914 obo:IAO_0000115 "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." ; obo:IAO_0000232 "contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers" ; oboInOwl:hasDbXref "AEO:0000114", "EHDAA2:0003114", "FBbt:00007474" ; oboInOwl:hasExactSynonym "epithelial or endothelial tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003914" ; a owl:Class ; rdfs:label "epithelial tube" ; rdfs:subClassOf obo:UBERON_0000025 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 ] ) ] . obo:UBERON_0003915 obo:IAO_0000115 "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003915" ; a owl:Class ; rdfs:label "endothelial tube" ; rdfs:subClassOf obo:UBERON_0003914 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 ] ) ] . obo:UBERON_0003916 obo:IAO_0000115 "A mass of closely packed fat cells (adipose tissue) surrounded by fibrous tissue septa[TMD]." ; obo:UBPROP_0000001 "An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue[BTO]." ; obo:UBPROP_0000012 "FMA says isa fascia organ. Note that XAO and AAO have structures called fat pad/body, but these are gonad-associated, so we place them with the gonad-specific subclass" ; oboInOwl:hasDbXref "BTO:0000444", "EMAPA:35340", "FMA:58616", "MA:0002481" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fat body" ; oboInOwl:id "UBERON:0003916" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "fat pad" ; rdfs:subClassOf obo:UBERON_0001013 . obo:UBERON_0003918 obo:IAO_0000115 "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." ; obo:IAO_0000116 "check this" ; oboInOwl:hasExactSynonym "mesenchyme of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003918" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0003920 obo:IAO_0000115 "A blood vessel that carries blood from the capillaries toward the heart." ; oboInOwl:hasDbXref "EMAPA:35932", "FMA:86188", "MA:0000066" ; oboInOwl:hasExactSynonym "segment of venous tree organ", "venous tree organ segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003920" ; a owl:Class ; rdfs:comment "Compare to: vein" ; rdfs:label "venous blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004582 ] ) ] . obo:UBERON_0003921 obo:IAO_0000115 "Embryonic structure that develops into pancreatic bud." ; obo:UBPROP_0000012 "in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds" ; obo:UBPROP_0000013 "revisit after standardizing terms 'primordium', 'anlagen', 'bud'" ; oboInOwl:hasDbXref "EFO:0002579", "EFO:0003434", "EHDAA2:0001382", "EHDAA:2163", "EMAPA:17066", "FMA:79792", "TAO:0000254", "XAO:0001101", "ZFA:0000254" ; oboInOwl:hasExactSynonym "pancreatic primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreatic anlage", "pancreatic endoderm", "primordial pancreas" ; oboInOwl:id "UBERON:0003921" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pancreas primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007026 ], _:genid132636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png"^^xsd:anyURI . obo:UBERON_0003922 obo:IAO_0000115 "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." ; oboInOwl:hasDbXref "EFO:0003470", "EMAPA:35645", "NCIT:C34242", "SCTID:360398004", "TAO:0001390", "UMLS:C1283285", "Wikipedia:Pancreatic_bud", "ZFA:0001390" ; oboInOwl:hasExactSynonym "pancreatic bud", "pancreatic buds" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreas epithelium", "pancreatic anlage" ; oboInOwl:id "UBERON:0003922" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "pancreatic epithelial bud" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001555 ], _:genid132644, _:genid132646, _:genid132649, _:genid132651 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png"^^xsd:anyURI . obo:UBERON_0003923 obo:IAO_0000115 "Pancreatic bud that gives rise to the accessory pancreatic duct." ; obo:UBPROP_0000001 "The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO]" ; obo:UBPROP_0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011031", "EFO:0003465", "EHDAA2:0001385", "EMAPA:17067", "SCTID:361435005", "TAO:0001370", "VHOG:0001428", "Wikipedia:Pancreatic_bud", "XAO:0000467", "ZFA:0001370" ; oboInOwl:hasExactSynonym "pancreas dorsal primordium duct bud", "pancreas primordium dorsal bud", "primary pancreatic bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal pancreas anlage", "dorsal pancreatic anlage", "posterior pancreatic anlage", "posterior pancreatic bud" ; oboInOwl:id "UBERON:0003923" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal pancreatic bud" ; rdfs:subClassOf obo:UBERON_0003922, _:genid132658, _:genid132660 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png"^^xsd:anyURI . obo:UBERON_0003924 obo:IAO_0000115 "Pancreatic bud that gives rise to the major pancreatic duct." ; obo:UBPROP_0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" ; obo:UBPROP_0000011 "The ventral pancreatic bud becomes the head and uncinate process, and comes from the hepatic diverticulum[WP]", "the ventral pancreas and liver are derived from a common precursor cell population[PMID:16417468]. TODO - add this relationship." ; oboInOwl:hasDbXref "AAO:0011111", "EFO:0003464", "EHDAA2:0001389", "EMAPA:17256", "SCTID:361437002", "TAO:0001369", "VHOG:0001429", "Wikipedia:Pancreatic_bud", "XAO:0001103", "ZFA:0001369" ; oboInOwl:hasExactSynonym "pancreas primordium ventral bud", "pancreas ventral primordium duct bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior pancreatic anlage", "anterior pancreatic bud", "ventral pancreas anlage", "ventral pancreatic anlage" ; oboInOwl:id "UBERON:0003924" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ventral pancreatic bud" ; rdfs:subClassOf obo:UBERON_0003922, _:genid132667, _:genid132669 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png"^^xsd:anyURI . obo:UBERON_0003928 obo:IAO_0000115 "A duct that is part of a digestive system [Automatically generated definition]." ; oboInOwl:hasDbXref "TAO:0005162", "ZFA:0005162" ; oboInOwl:hasExactSynonym "duct of digestive system", "duct of gastrointestinal system", "gastrointestinal system duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003928" ; a owl:Class ; rdfs:label "digestive system duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ] ) ] . obo:UBERON_0003929 obo:IAO_0000115 "An epithelium that lines the lumen of the digestive tract." ; obo:UBPROP_0000001 "Epithelium lining the lumen of the gut.[TAO]" ; obo:UBPROP_0000008 "" ; oboInOwl:hasDbXref "BTO:0000956", "EHDAA2:0004567", "EMAPA:32928", "FBbt:00047143", "MA:0003201", "NCIT:C12963", "TAO:0005123", "UMLS:C0836205", "XAO:0003200", "ZFA:0005123" ; oboInOwl:hasExactSynonym "digestive tract epithelial tissue", "epithelial tissue of digestive tract", "epithelial tissue of gut", "epithelium of digestive tract", "epithelium of gut", "gastrodermis", "gut epithelial tissue", "gut epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alimentary tract epithelium" ; oboInOwl:id "UBERON:0003929" ; a owl:Class ; rdfs:label "digestive tract epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0003930 obo:IAO_0000115 "Endocardium that is part of the atrioventricular canal[ZFA,vetted]." ; oboInOwl:hasDbXref "TAO:0002170", "XAO:0004124", "ZFA:0001616" ; oboInOwl:hasExactSynonym "AV canal endocardium", "AVC endocardium", "endocardium of AV canal", "endocardium of atrioventricular canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003930" ; a owl:Class ; rdfs:label "atrioventricular canal endocardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002087 ] ) ] . obo:UBERON_0003931 obo:IAO_0000115 "White matter that is part of a diencephalon [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0023148" ; oboInOwl:hasDbXref "BIRNLEX:1678", "FMA:83931", "TAO:0000338", "ZFA:0000338" ; oboInOwl:hasExactSynonym "diencephalic tract/commissure", "diencephalic tracts and commissures", "predominantly white regional part of diencephalon", "white matter of diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003931" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "diencephalic white matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid131567 ] . obo:UBERON_0003932 obo:IAO_0000115 "A cartilage element of chondrocranium. Example: neurocranial trabecula." ; oboInOwl:hasDbXref "EFO:0003690", "TAO:0001461", "ZFA:0001461" ; oboInOwl:hasExactSynonym "cartilage of chondrocranium", "cartilaginous element of chondrocranium", "chondrocranium cartilage", "neurocranium cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003932" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "cartilage element of chondrocranium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 ] ) ] . obo:UBERON_0003933 obo:IAO_0000115 "A cartilage element that is part of the cranial skeleton." ; obo:UBPROP_0000001 "Cartilage which is part of the cranium.[TAO]" ; oboInOwl:hasDbXref "TAO:0001458", "ZFA:0001458" ; oboInOwl:hasExactSynonym "cartilage of cranium", "cranium cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial cartilages" ; oboInOwl:id "UBERON:0003933" ; a owl:Class ; rdfs:label "cranial cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010323 ] ) ] . obo:UBERON_0003937 obo:IAO_0000115 "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." ; oboInOwl:hasDbXref "MA:0001751" ; oboInOwl:hasExactSynonym "genitalia gland", "gland of genitalia", "gland of reproductive system", "reproductive gland", "reproductive system gland", "sex gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003937" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "reproductive gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ] ) ] . obo:UBERON_0003942 obo:IAO_0000115 "The sensory system for the sense of touch and pain." ; obo:UBPROP_0000001 "The neural tissue involved in the transmission of sensory signals" ; obo:UBPROP_0000012 "MP defines this in a may more appropriate to somatosensory cortex" ; oboInOwl:hasAlternativeId "UBERON:0014511" ; oboInOwl:hasDbXref "EMAPA:37954", "NLXANAT:090818", "Wikipedia:Somatosensory_system", "neuronames:2887" ; oboInOwl:hasExactSynonym "somatic sensory system", "system for detection of somatic senses" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003942" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "somatosensory system" ; rdfs:subClassOf obo:UBERON_0001032, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0019233 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0050975 ] . obo:UBERON_0003946 obo:IAO_0000115 "The placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood." ; obo:UBPROP_0000008 "Mouse-human differences: The mouse and human placentas have labyrinthine and villous types of interdigitation between maternal and fetal tissues, respectively ... The mouse placental labyrinth is composed of an intricate network of maternal blood spaces and embryonal blood vessels. Maternal and embryonal blood is separated by a placental barrier that consists of four cellular layers: layer I trophoblasts line the maternal lacunae, trophoblasts in layers II and III form syncytial-like layers, and endothelial cells line the embryonic vessels[DOI: 10.1073/pnas.96.14.8138 ]" ; oboInOwl:hasExactSynonym "labyrinthine layer", "labyrinthine layer of placenta", "placental labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003946" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "placenta labyrinth" ; rdfs:seeAlso "http://placentation.ucsd.edu/placenta.html"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001987 ] . obo:UBERON_0003947 obo:IAO_0000115 "The brain ventricles or their associated choroid plexuses." ; obo:IAO_0000116 "TODO - check relationship between CP and BV. If this is part of then this class should be obsoleted", "TODO merge into BV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003947" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain ventricle/choroid plexus" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001886 obo:UBERON_0004086 ) ] . obo:UBERON_0003951 obo:IAO_0000115 "The posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope." ; obo:IAO_0000116 "TODO - check relationships" ; oboInOwl:hasDbXref "EMAPA:37916", "GAID:908", "MESH:D005654", "NCIT:C13378", "RETIRED_EHDAA2:0000583", "SCTID:362519003", "UMLS:C0740422", "Wikipedia:Fundus_(eye)", "galen:FundusOculi" ; oboInOwl:hasExactSynonym "eye fundus", "fundus", "fundus oculi", "fundus of eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003951" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ocular fundus" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001802 ], _:genid131622 . obo:UBERON_0003952 obo:IAO_0000115 "The anterior segment of the lamellated connective tissue layer of the cornea." ; oboInOwl:hasBroadSynonym "anterior stroma" ; oboInOwl:hasDbXref "EMAPA:37414" ; oboInOwl:hasExactSynonym "cornea anterior stroma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003952" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "anterior stroma of cornea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001777 ] ; owl:disjointWith obo:UBERON_0003953 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0001777 ] ) ] . obo:UBERON_0003953 obo:IAO_0000115 "The posterior segment of the lamellated connective tissue layer of the cornea." ; oboInOwl:hasBroadSynonym "posterior stroma" ; oboInOwl:hasDbXref "EMAPA:37415" ; oboInOwl:hasExactSynonym "cornea posterior stroma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003953" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior stroma of cornea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0001777 ] ) ] . obo:UBERON_0003954 obo:IAO_0000115 "The articulation of the squamous portion of the temporal bones with the parietal bones[MP]. The squamosal suture arches backward from the pterion and connects the temporal squama with the lower border of the parietal: this suture is continuous behind with the short, nearly horizontal parietomastoid suture, which unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP]." ; oboInOwl:hasDbXref "EMAPA:19228", "FMA:52946", "SCTID:136248004", "SCTID:334174000", "Wikipedia:Squamosal_suture" ; oboInOwl:hasExactSynonym "squamo-parietal suture", "squamoparietal suture of skull", "sutura squamosa cranii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "squamosal suture", "squamous suture", "squamous suture of skull" ; oboInOwl:id "UBERON:0003954" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "squamoparietal suture" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0010155 ] ; owl:equivalentClass _:genid131648 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a8/Gray188-Squamosal_suture.png"^^xsd:anyURI . obo:UBERON_0003955 obo:IAO_0000115 "The part of a molar that is covered by enamel." ; oboInOwl:hasDbXref "EMAPA:37910", "FMA:85301" ; oboInOwl:hasExactSynonym "crown of molar tooth", "molar tooth crown", "molar tooth tooth crown", "tooth crown of molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003955" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "molar crown" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003655 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003675 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0003956 obo:IAO_0000115 "The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins." ; oboInOwl:hasDbXref "EMAPA:37427" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003956" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aqueous drainage system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001768 ] . obo:UBERON_0003959 obo:IAO_0000115 "An anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia[WP]." ; obo:IAO_0000116 "add more specific classification e.g. anastomosing network - consider FMA:3726" ; oboInOwl:hasDbXref "EMAPA:18332", "FMA:19834", "GAID:399", "MA:0003013", "MESH:D012152", "NCIT:C33467", "SCTID:279617009", "UMLS:C0035278", "Wikipedia:Rete_testis" ; oboInOwl:hasExactSynonym "Haller's rete" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003959" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "rete testis" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005051 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:CL_0000019 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0001343 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0006946 ], _:genid132818 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg"^^xsd:anyURI . obo:UBERON_0003960 obo:IAO_0000115 "Slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments." ; oboInOwl:hasDbXref "EMAPA:36320", "FMA:52877", "SCTID:138874009", "Wikipedia:Temporal_styloid_process" ; oboInOwl:hasExactSynonym "processus styloideus", "processus styloideus ossis temporalis", "styloid process", "styloid process of petrous part of temporal bone", "temporal styloid process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "processus styloideus ossis temporalis" ; oboInOwl:id "UBERON:0003960" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Disease notes: Eagle's syndrome" ; rdfs:label "styloid process of temporal bone" ; rdfs:subClassOf obo:UBERON_0004530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001678 ], _:genid132827, _:genid132829 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray137.png"^^xsd:anyURI . obo:UBERON_0003967 obo:IAO_0000115 "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." ; oboInOwl:hasDbXref "EMAPA:37841" ; oboInOwl:hasNarrowSynonym "cutaneous elastic fiber", "dermal elastic fiber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003967" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cutaneous elastic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000014 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002521 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000014 ] ) ] . obo:UBERON_0003968 obo:IAO_0000115 "The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes." ; oboInOwl:hasDbXref "EMAPA:37938" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003968" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "peripheral lymph node" ; rdfs:subClassOf obo:UBERON_0000029 . obo:UBERON_0003970 obo:IAO_0000115 "Blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate." ; oboInOwl:hasExactSynonym "placental labyrinth vascular network", "vasculature of placenta labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "placental vasculature" ; oboInOwl:id "UBERON:0003970" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "placental labyrinth vasculature" ; rdfs:subClassOf obo:UBERON_0002049 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003946 ] ) ] . obo:UBERON_0003975 obo:IAO_0000115 "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." ; oboInOwl:hasDbXref "BTO:0003099", "FMA:45654", "SCTID:303518005" ; oboInOwl:hasExactSynonym "female internal genitalia", "internal female genital organ", "internal genitalia of female reproductive system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organa genitalia feminina interna" ; oboInOwl:id "UBERON:0003975" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "internal female genitalia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004175 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0003978 obo:UBPROP_0000007 "valvular" ; oboInOwl:hasDbXref "EHDAA2:0004046", "EHDAA:1892", "EHDAA:4406", "FMA:67611", "galen:Valve" ; oboInOwl:hasExactSynonym "anatomical valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003978" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "valve" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0065008 ] . obo:UBERON_0003980 obo:IAO_0000115 "One of a set of deep furrows which divide the lobules of the cerebellum. Examples: postcentral, primary and secondary furrows." ; obo:UBPROP_0000202 obo:FMA_77789 ; oboInOwl:hasDbXref "BAMS:CBf", "DHBA:12828", "EMAPA:37818", "FMA:321547", "HBA:9406", "SCTID:314163001", "neuronames:1213" ; oboInOwl:hasExactSynonym "cerebellar fissure", "fissurae cerebelli" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellar fissures", "cerebellar fissures set", "cerebellar sulci", "cerebellar sulcus", "set of cerebellar fissures", "sulcus of cerebellum" ; oboInOwl:id "UBERON:0003980" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebellum fissure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014466 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0003983 obo:IAO_0000115 "A conical pouch formed from the upper and left angle of the right ventricle in the chordate heart, from which the pulmonary artery arises[WP]. the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminates in the pulmonary trunk[MP]." ; obo:UBPROP_0000001 "Receives blood from the left atrium and becomes the median truncus arteriosus.[AAO]" ; obo:UBPROP_0000008 "Kardong says absent in adult tetrapods, check AAO" ; obo:UBPROP_0000013 "we use the term CA for the anterior chamber if it is composed of cardiac muscle, contractile, and contains conal valves internally" ; oboInOwl:hasDbXref "AAO:0010250", "Wikipedia:Conus_arteriosus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003983" ; a owl:Class ; rdfs:label "conus arteriosus" ; rdfs:subClassOf obo:UBERON_0004151, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png"^^xsd:anyURI . obo:UBERON_0003984 obo:IAO_0000115 "The funnel-like expansion of the abdominal extremity of the uterine tube[MP]." ; obo:UBPROP_0000001 "The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]." ; obo:UBPROP_0000008 "In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct." ; oboInOwl:hasBroadSynonym "infundibulum" ; oboInOwl:hasDbXref "EMAPA:29897", "FMA:18307", "SCTID:362262001", "Wikipedia:Infundibulum_of_uterine_tube" ; oboInOwl:hasExactSynonym "infundibulum of oviduct", "infundibulum of uterine tube" ; oboInOwl:hasNarrowSynonym "infundibulum of fallopian tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "infundibulum tubae uterinae" ; oboInOwl:id "UBERON:0003984" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "uterine tube infundibulum" ; rdfs:subClassOf obo:UBERON_0013515 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg"^^xsd:anyURI . obo:UBERON_0003988 obo:IAO_0000115 "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells." ; oboInOwl:hasDbXref "EMAPA:37974" ; oboInOwl:hasExactSynonym "thymic cortico-medullary boundary", "thymic corticomedullary boundary", "thymic corticomedullary junction", "thymic corticomedullary zone", "thymus CMZ", "thymus cortico-medullary boundary", "thymus corticomedullary junction", "thymus corticomedullary zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0003988" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thymus corticomedullary boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002125 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000451 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000542 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000881 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001980 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002125 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002123 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002124 ] ) ] . obo:UBERON_0003999 obo:IAO_0000115 "The main curve of the hyoid bone, from which the horns extend." ; oboInOwl:hasDbXref "EMAPA:18653", "FMA:59495", "MA:0002958", "SCTID:369006007", "Wikipedia:Body_of_hyoid_bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "base of hyoid bone", "basihyal bone", "basihyoid bone", "body of hyoid", "body of hyoid bone", "corpus ossis hyoidei", "hyoid bone base" ; oboInOwl:id "UBERON:0003999" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hyoid bone body" ; rdfs:subClassOf obo:UBERON_0010273, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001685 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Gray186.png"^^xsd:anyURI . obo:UBERON_0004000 obo:IAO_0000115 "A sac-like structure comprising a sebaceous gland." ; oboInOwl:hasDbXref "EMAPA:37972" ; oboInOwl:hasExactSynonym "Meibomian gland acinus", "acinus of tarsal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palpebral gland acinus" ; oboInOwl:id "UBERON:0004000" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tarsal gland acinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001818 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001818 ] ) ] . obo:UBERON_0004001 obo:IAO_0000115 "." ; obo:IAO_0000116 "TODO - check isa parentage" ; oboInOwl:hasDbXref "EMAPA:37917", "NLXANAT:20090402" ; oboInOwl:hasExactSynonym "cytoarchitectural part of olfactory bulb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004001" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "olfactory bulb layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002264 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002264 ] ) ] . obo:UBERON_0004008 obo:IAO_0000115 "The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium." ; oboInOwl:hasDbXref "DHBA:12698", "EHDAA2:0004401", "neuronames:1373" ; oboInOwl:hasExactSynonym "cerebellum plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellum roof plate" ; oboInOwl:id "UBERON:0004008" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebellar plate" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid132940, _:genid132942 . obo:UBERON_0004014 obo:IAO_0000115 "One of the folds of skin which form the inner lips on both sides of the vaginal opening." ; oboInOwl:hasDbXref "FMA:20374", "MA:0002845", "NCIT:C12307", "SCTID:362240001", "UMLS:C0227766", "Wikipedia:Labia_minora", "galen:LabiaMinora" ; oboInOwl:hasExactSynonym "labia minorum", "labium minora", "labium minorum", "labium minus", "labium minus pudendi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004014" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "labium minora" ; rdfs:subClassOf obo:UBERON_0004084, _:genid132946, _:genid132948 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Vulva_labeled_english.jpg"^^xsd:anyURI . obo:UBERON_0004015 obo:IAO_0000115 "The connection between the embryo proper and extraembryonic tissues." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004015" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "embryonic-extraembryonic boundary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000015 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000478 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002050 ] ) ] . obo:UBERON_0004016 obo:IAO_0000115 "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." ; obo:UBPROP_0000013 "Not to be confused with 'dermatome segment of skin'." ; oboInOwl:hasDbXref "AAO:0011028", "AEO:0001017", "EHDAA2_RETIRED:0003428", "EHDAA:1719", "EHDAA:1725", "EHDAA:1731", "EHDAA:1737", "EMAPA:32838", "FMA:295656", "NCIT:C61572", "UMLS:C0180383", "Wikipedia:Dermatome_(embryology)", "XAO:0000220" ; oboInOwl:hasExactSynonym "cutis plate", "dermatomal mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epimere mesoderm", "mesenchyma dermatomiale" ; oboInOwl:id "UBERON:0004016" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dermatome" ; rdfs:subClassOf obo:UBERON_0017650, _:genid132963, _:genid132965 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png"^^xsd:anyURI . obo:UBERON_0004022 obo:IAO_0000115 "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." ; obo:UBPROP_0000011 "As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047]" ; oboInOwl:hasExactSynonym "germinal neuroepithelial layer", "germinal neuroepithelium", "original neural tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004022" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "germinal neuroepithelium" ; rdfs:subClassOf obo:UBERON_0034706, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003842 ] ; owl:disjointWith obo:UBERON_0006934 . obo:UBERON_0004035 obo:IAO_0000115 "The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate." ; obo:UBPROP_0000011 "The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects" ; oboInOwl:hasBroadSynonym "SP" ; oboInOwl:hasDbXref "DHBA:10522", "EMAPA:32703", "PBA:294021932", "Wikipedia:Subplate", "https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png/360px-Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png", "neuronames:3233" ; oboInOwl:hasExactSynonym "cerebral cortex subplate", "subplate", "subplate zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004035" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cortical subplate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0034711 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014950 _:genid131832 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005343 ] ) ] . obo:UBERON_0004040 obo:IAO_0000115 "The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone." ; oboInOwl:hasBroadSynonym "IZ" ; oboInOwl:hasDbXref "EMAPA:17545", "EMAPA:32712" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebral cortex mantle layer", "cerebral cortex mantle zone", "cortical mantle layer" ; oboInOwl:id "UBERON:0004040" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cortical intermediate zone" ; rdfs:subClassOf obo:UBERON_0014950, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004061 ] . obo:UBERON_0004041 obo:IAO_0000115 "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp." ; obo:UBPROP_0000012 "FMA:15843 is classified as primary follicle so it belongs here" ; oboInOwl:hasDbXref "EMAPA:37960", "FMA:15843" ; oboInOwl:hasExactSynonym "primary spleen B cell follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004041" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen primary B follicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010422 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0004042 obo:IAO_0000115 "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp." ; oboInOwl:hasDbXref "EMAPA:37961" ; oboInOwl:hasExactSynonym "secondary spleen B cell follicle", "splenic secondary B cell follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004042" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen secondary B follicle" ; rdfs:subClassOf _:genid133008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001745 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0004053 obo:IAO_0000115 "The external masculine genital organs, including the penis and scrotum." ; oboInOwl:hasDbXref "BTO:0003097", "EMAPA:30977", "FMA:45642", "SCTID:362264000", "galen:MaleExternalGenitalia" ; oboInOwl:hasExactSynonym "external male genital organ", "male external genitalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organa genitalia masculina externa" ; oboInOwl:id "UBERON:0004053" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "external male genitalia" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000079 ] ; owl:disjointWith obo:UBERON_0005056, obo:UBERON_0009196 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004176 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0004054 obo:IAO_0000115 "The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands." ; obo:IAO_0000116 "consider splitting genitalia from genital organ" ; oboInOwl:hasDbXref "BTO:0003096", "FMA:45655", "SCTID:310536002" ; oboInOwl:hasExactSynonym "internal male genital organ", "male internal genitalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organa genitalia masculina interna" ; oboInOwl:id "UBERON:0004054" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "internal male genitalia" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000079 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004175 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0004058 obo:IAO_0000115 "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." ; obo:UBPROP_0000012 "In ZFA, Digestive system duct that collects bile from the canaliculus and transports bile through the liver -- (check if the same) // The smallest and the most peripheral branches of the biliary tree consist of a portal part (portal ductule) and an intralobular part (intralobular ductule)" ; oboInOwl:hasDbXref "BTO:0002840", "EMAPA:37440", "TAO:0005164", "ZFA:0005164" ; oboInOwl:hasExactSynonym "bile ductule", "biliary ductule", "ductuli biliferi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bile capillary", "biliary ductule", "cholangiole", "terminal cholangiole" ; oboInOwl:id "UBERON:0004058" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "biliary ductule" ; rdfs:subClassOf obo:UBERON_0000025, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001175 ], _:genid133033 . obo:UBERON_0004060 obo:IAO_0000115 "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." ; obo:IAO_0000116 "consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure" ; obo:UBPROP_0000001 "The layer of undifferentiated, proliferating cells that line the neural tube lumen" ; oboInOwl:hasBroadSynonym "ependymal layer" ; oboInOwl:hasDbXref "EMAPA:17152", "EMAPA:35362", "EMAPA_RETIRED:16783", "MA:0003193" ; oboInOwl:hasExactSynonym "neural tube ependymal layer", "neural tube ventricular germinal zone", "neural tube ventricular zone" ; oboInOwl:hasNarrowSynonym "neural tube ependymal zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004060" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neural tube ventricular layer" ; rdfs:subClassOf obo:UBERON_0034706, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003842 ], _:genid133049 . obo:UBERON_0004061 obo:IAO_0000115 "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." ; oboInOwl:hasDbXref "EMAPA:17148", "EMAPA:35360", "neuronames:1367" ; oboInOwl:hasExactSynonym "neural tube intermediate zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future brain marginal layer" ; oboInOwl:id "UBERON:0004061" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neural tube mantle layer" ; rdfs:subClassOf obo:UBERON_0034707, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004060 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004062 ], _:genid133060 . obo:UBERON_0004062 obo:IAO_0000115 "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." ; oboInOwl:hasDbXref "EMAPA:17151", "neuronames:1368" ; oboInOwl:hasExactSynonym "neural tube marginal zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain marginal zone" ; oboInOwl:id "UBERON:0004062" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neural tube marginal layer" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004061 ], _:genid133068 . obo:UBERON_0004064 obo:IAO_0000115 "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." ; oboInOwl:hasDbXref "AAO:0010561", "EFO:0001904", "NCIT:C34111", "UMLS:C1511061", "Wikipedia:Basal_plate_(neural_tube)", "neuronames:1372" ; oboInOwl:hasExactSynonym "basal plate", "basal plate of neural tube" ; oboInOwl:hasNarrowSynonym "spinal cord basal plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "motor part of neural tube", "ventral part of neural tube" ; oboInOwl:id "UBERON:0004064" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "neural tube basal plate" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004061 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000100 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000102 ; owl:someValuesFrom obo:UBERON_0005478 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004061 ], _:genid133076 . obo:UBERON_0004066 obo:IAO_0000115 "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." ; oboInOwl:hasAlternativeId "UBERON:0006237" ; oboInOwl:hasDbXref "EHDAA2:0000578", "EHDAA:4778", "EMAPA:16681", "FMA:293101", "NCIT:C34182", "SCTID:361486000", "UMLS:C1517321", "VHOG:0001319", "Wikipedia:Frontonasal_prominence" ; oboInOwl:hasExactSynonym "embryonic frontonasal prominence" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forebrain prominence", "frontonasal mass", "frontonasal process", "prominentia frontonasalis" ; oboInOwl:id "UBERON:0004066" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "frontonasal prominence" ; rdfs:subClassOf obo:UBERON_0009292, [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0000033 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png"^^xsd:anyURI . obo:UBERON_0004067 obo:IAO_0000115 "The lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it." ; oboInOwl:hasDbXref "EHDAA2:0000916", "EHDAA:4786", "EMAPA:16805", "FMA:295864", "SCTID:308880000", "Wikipedia:Lateral_nasal_prominence" ; oboInOwl:hasExactSynonym "lateral nasal process", "latero-nasal process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral nasal swelling", "prominentia nasalis lateralis" ; oboInOwl:id "UBERON:0004067" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lateral nasal prominence" ; rdfs:subClassOf obo:UBERON_0009292, _:genid133091, _:genid133093 ; owl:disjointWith obo:UBERON_0004068 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png"^^xsd:anyURI . obo:UBERON_0004068 obo:IAO_0000115 "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." ; obo:UBPROP_0000011 "Fusion of right and left medial nasal processes forms a primary palate rostrally and the nasal septum caudally. The incisive bone, including upper incisor teeth and the rostral up- per lip, are derived from the primary palate. The nasal septum consists of bone, cartilage, and a patch of soft tissue membrane that separates right & left halves of the nasal cavity." ; oboInOwl:hasDbXref "EHDAA2:0001076", "EHDAA:4792", "EMAPA:16808", "FMA:295858", "SCTID:308877001", "VHOG:0000804", "Wikipedia:Medial_nasal_prominence" ; oboInOwl:hasExactSynonym "medial nasal process", "medial-nasal process", "prominentia nasalis medialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial nasal swelling", "nasomedial prominence" ; oboInOwl:id "UBERON:0004068" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "medial nasal prominence" ; rdfs:subClassOf obo:UBERON_0009292, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0008816 ], _:genid133101, _:genid133104 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png"^^xsd:anyURI . obo:UBERON_0004084 obo:IAO_0000115 "One of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening." ; obo:UBPROP_0000007 "labial" ; oboInOwl:hasDbXref "CALOHA:TS-2210", "EMAPA:30837", "FMA:321903", "MA:0002464", "NCIT:C52559", "UMLS:C0227759", "galen:Labia" ; oboInOwl:hasExactSynonym "genital labia", "labia", "labium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004084" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "genital labium" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005056 ], _:genid133112, _:genid133114 . obo:UBERON_0004085 obo:IAO_0000115 "One of the folds of skin which form the outer lips on both sides of the vaginal opening." ; oboInOwl:hasDbXref "FMA:20367", "MA:0002844", "NCIT:C12306", "SCTID:362237001", "UMLS:C0227760", "Wikipedia:Labia_majora", "galen:LabiaMajora" ; oboInOwl:hasExactSynonym "labia majorum", "labium majora", "labium majorum", "labium majus", "labium majus pudendi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004085" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "labium majora" ; rdfs:subClassOf obo:UBERON_0004084, _:genid133122 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/26/Gray1229.png"^^xsd:anyURI . obo:UBERON_0004086 obo:IAO_0000115 "One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid." ; obo:UBPROP_0000001 "Organ cavity of the brain which consists of the lateral ventricles, the third and fourth ventricles and the cerebral aqueduct[BIRNLEX:1356]." ; obo:UBPROP_0000012 "FMA draws the distinction between e.g. 'fourth ventricle' and 'cavity of fourth ventricle'. The latter is a cavity, and part of the former, which is a region. The superclass of 'fourth ventricle' is_a 'region of ventricular system of the brain'. We place this class here, although it is not equivalent to ventricles, as it includes ventricle bodies." ; oboInOwl:hasDbXref "BIRNLEX:1356", "BTO:0001442", "EFO:0001914", "EMAPA:32674", "FMA:78447", "HBA:9418", "MA:0000818", "MESH:D002552", "NCIT:C12356", "SCTID:180929003", "UMLS:C0007799", "neuronames:2497" ; oboInOwl:hasExactSynonym "brain ventricles", "cerebral ventricle", "region of ventricular system of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004086" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "brain ventricle" ; rdfs:subClassOf obo:UBERON_0005358, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005282 ] . obo:UBERON_0004087 obo:IAO_0000115 "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." ; oboInOwl:hasDbXref "AAO:0010215", "BTO:0001438", "EMAPA:18415", "FMA:321896", "GAID:547", "MA:0000068", "MESH:D014684", "NCIT:C12817", "SCTID:244405007", "UMLS:C0042460", "Wikipedia:Venae_cavae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caval vein", "venae cavae" ; oboInOwl:id "UBERON:0004087" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vena cava" ; rdfs:subClassOf obo:UBERON_0001638, obo:UBERON_0013768, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png"^^xsd:anyURI . obo:UBERON_0004088 obo:IAO_0000115 "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." ; obo:IAO_0000116 "note the FMA class is more narrow though, and is more like eye + muscles + vasculature. The FMA also has FMA:72951 orbital part of eye" ; obo:UBPROP_0000012 "in HP covers eyelid, eyebrow." ; oboInOwl:hasDbXref "FMA:260119" ; oboInOwl:hasExactSynonym "content of orbital part of eye", "eye region", "orbital part of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ocular and peri-ocular region", "ocular region", "orbital content", "orbital part of eye" ; oboInOwl:id "UBERON:0004088" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "orbital region" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] . obo:UBERON_0004089 obo:IAO_0000115 "The middle of the face including the nose and its associated bony structures[MW]." ; obo:IAO_0000116 "this class is currently a union of the snout (e.g. in mouse), the midface and the lower face. Note that in MA, snout includes the whole jaw and should thus be more alike the lower face than the midface, so its placement here is not strictly accurate. In future we might introduce specific classes for each of these, and include the full parthood relationships. if this is done, then care should be taken to preserve inferences such as an abnormality of the lower face being an abnormality of the midface." ; obo:UBPROP_0000007 "midfacial" ; oboInOwl:hasDbXref "EMAPA:32806", "FMA:285406", "MA:0001910" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower face", "midface/lower face", "snout" ; oboInOwl:id "UBERON:0004089" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "midface" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001456 ] . obo:UBERON_0004090 obo:IAO_0000115 "." ; obo:UBPROP_0000012 "does not contain any subparts in FMA. In HP covers eyelid, eyebrow, soft tissue" ; oboInOwl:hasDbXref "FMA:59351", "MA:0002875", "SCTID:362646004", "Wikipedia:Periorbita" ; oboInOwl:hasExactSynonym "periorbita", "periorbital area" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004090" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "periorbital region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002515 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0004867 ] . obo:UBERON_0004092 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004092" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hypothalamus-pituitary axis" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ] . obo:UBERON_0004096 obo:IAO_0000115 "The toothlike process on the upper surface of the axis, which articulates with the atlas above[GAID]." ; obo:IAO_0000116 "TODO check AAO:0000721 odontoid_process -- Anterior process located between the atlantal cotyles that projects into the foramen magnum of the skull and bears facets that articulate with the lateral walls of the foramen" ; obo:UBPROP_0000001 "Anterior process located between the atlantal cotyles that projects into the foramen magnum of the skull and bears facets that articulate with the lateral walls of the foramen.[AAO]" ; oboInOwl:hasAlternativeId "UBERON:0005210" ; oboInOwl:hasDbXref "AAO:0000721", "EMAPA:26535", "FMA:24043", "GAID:238", "MA:0002872", "MESH:D009809", "NCIT:C86970", "SCTID:181899003", "UMLS:C0028881", "Wikipedia:Dens_(anatomy)" ; oboInOwl:hasExactSynonym "axis dens", "axis odontoid process", "cervical vertebra 2 odontoid process", "dens", "dens axis", "dens of axis", "odontoid process", "odontoid process of axis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "odontoid" ; oboInOwl:id "UBERON:0004096" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "odontoid process of cervical vertebra 2" ; rdfs:subClassOf obo:UBERON_0004530, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001093 ] . obo:UBERON_0004098 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004098" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tibial plateaux" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] . obo:UBERON_0004099 obo:IAO_0000115 "Joint cavity shared by all the joints of the elbow. The elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis. All three share a joint cavity which is highly sinuated/scalloped/coved. Joint spaces of the elbow summarizes the joint cavity shared by all three adjoining joints of the elbow joint." ; oboInOwl:hasDbXref "FMA:38911" ; oboInOwl:hasExactSynonym "synovial cavity of elbow joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004099" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "joint space of elbow" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001490 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001490 ] ) ] . obo:UBERON_0004100 obo:IAO_0000115 "The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone." ; oboInOwl:hasDbXref "FMA:265239", "SCTID:279371005", "Wikipedia:Collecting_duct_system" ; oboInOwl:hasExactSynonym "collecting duct system", "kidney collecting duct system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tubulus renalis colligens" ; oboInOwl:id "UBERON:0004100" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "renal collecting system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png"^^xsd:anyURI . obo:UBERON_0004101 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004101" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasolabial region" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] . obo:UBERON_0004103 obo:IAO_0000115 "One of the two jaw ridges either on the roof of the mouth between the upper teeth and the hard palate or on the bottom of the mouth behind the lower teeth[WP]. The alveolar ridges contain the sockets (alveoli) of the teeth[HP]." ; obo:UBPROP_0000012 "in BTO, this is part of an embryo" ; oboInOwl:hasDbXref "BTO:0001383", "EMAPA:35118", "FMA:313923", "GAID:215", "MA:0003119", "MESH:D000539", "NCIT:C89749", "SCTID:245790000", "UMLS:C0447411", "Wikipedia:Alveolar_ridge" ; oboInOwl:hasExactSynonym "alveolar body", "alveolar bone", "alveolar margin", "alveolar process", "margo alveolaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004103" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "alveolar ridge" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ], _:genid133191 . obo:UBERON_0004104 obo:IAO_0000115 "Anatomical line demarcating the boundary between forehead and scalp." ; oboInOwl:hasDbXref "FMA:285412" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004104" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hairline" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0008200 ] ) ] . obo:UBERON_0004105 obo:IAO_0000115 "Region beneath a nail or claw." ; obo:IAO_0000116 "consider merging with nailbed" ; obo:UBPROP_0000007 "subungual" ; oboInOwl:hasDbXref "CALOHA:TS-2351" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004105" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "subungual region" ; rdfs:subClassOf obo:UBERON_0000477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001705 ] . obo:UBERON_0004106 obo:IAO_0000115 "Horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear." ; oboInOwl:hasDbXref "FMA:61024", "NCIT:C32410", "SCTID:362547004", "UMLS:C0229319" ; oboInOwl:hasExactSynonym "crus helicis", "crus of helical part of auricular cartilage", "crus of helix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004106" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "crus of ear" ; rdfs:subClassOf obo:UBERON_0007844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001848 ], _:genid133210 . obo:UBERON_0004108 obo:IAO_0000115 "Part of the cranium, the clivus is a shallow depression behind the dorsum sellC& that slopes obliquely backward. It forms a gradual sloping process at the anterior most portion of the basilar occipital bone at its junction with the sphenoid bone. On axial planes, it sits just posterior to the sphenoid sinuses. Just lateral to the clivus bilaterally is the foramen lacerum which contains the internal carotid artery, proximal to its anastamosis with the Circle of Willis. Posterior to the clivus is the basilar artery. The clivus supports the upper part of the pons." ; obo:IAO_0000116 "check relationships." ; oboInOwl:hasDbXref "FMA:75747", "NCIT:C12494", "SCTID:361736007", "UMLS:C0222724", "Wikipedia:Clivus_(anatomy)", "neuronames:674" ; oboInOwl:hasExactSynonym "clivus", "occipital bone clivus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Wackenheim's clivus line", "clivus ossis occipitalis" ; oboInOwl:id "UBERON:0004108" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "The clivus is an important landmark for checking for anatomical atlanto-occipital alignment; the clivus, when viewed on a lateral C-spine X-ray, forms a line which, if extended, is known as Wackenheim's clivus line. Wackenheim's clivus line should pass through the dens of the axis or be tangential to it." ; rdfs:label "clivus of occipital bone" ; rdfs:subClassOf obo:UBERON_0005913, _:genid133217, _:genid133219, _:genid133221 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c5/Clivus.png"^^xsd:anyURI . obo:UBERON_0004109 obo:IAO_0000115 "The outer or sperficial part of the humerus." ; oboInOwl:hasDbXref "FMA:31542" ; oboInOwl:hasExactSynonym "compact bone of humerus", "cortex of the humerus", "humerus compact bone", "humerus cortical bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004109" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cortex of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001439 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_0004110 obo:IAO_0000115 "An anatomical cavity that is the combination of the cavity between the nares and the choanae[HP,modified]." ; oboInOwl:hasDbXref "FMA:59675" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004110" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "midnasal cavity" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001707 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004771 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005928 ] . obo:UBERON_0004111 obo:IAO_0000115 "Any tube, opening or passage that connects two distinct anatomical spaces." ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000012 "FMA has both conduit and conduit space. In EHDAA2 this is a surface feature" ; oboInOwl:hasDbXref "AEO:0000080", "EHDAA2:0003080", "FMA:242873", "SCTID:346902003", "Wikipedia:Foramen" ; oboInOwl:hasNarrowSynonym "foramen", "foramina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "opening", "ostia", "ostium" ; oboInOwl:id "UBERON:0004111" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical conduit" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0000464 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0013686 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0000061 ] ) ] . obo:UBERON_0004113 obo:IAO_0000115 "A muscle of the tympanic cavity that attaches to an auditory ossicle." ; obo:UBPROP_0000009 "attenuate low-frequency sounds, reduce masking of high-frequency sounds by low-frequency sounds, frequency-selection filter" ; oboInOwl:hasAlternativeId "UBERON:0004112" ; oboInOwl:hasDbXref "EMAPA:37776", "FMA:49026", "MA:0000256", "NCIT:C33148", "SCTID:244778009", "UMLS:C1513769", "Wikipedia:Muscles_of_auditory_ossicles" ; oboInOwl:hasExactSynonym "auditory ossicles muscle", "muscle of auditory ossicles", "muscle of tympanic cavity", "ossicular muscle", "tympanic cavity muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle of middle ear" ; oboInOwl:id "UBERON:0004113" ; a owl:Class ; rdfs:label "muscle of auditory ossicle" ; rdfs:subClassOf obo:UBERON_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004114 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001686 ] ) ] . obo:UBERON_0004114 obo:IAO_0000115 "Small cavity surrounding the bones of the middle ear." ; oboInOwl:hasDbXref "BTO:0002098", "EHDAA2:0004119", "EMAPA:37778", "FMA:56461", "SCTID:362551002", "Wikipedia:Tympanic_cavity" ; oboInOwl:hasExactSynonym "anatomical cavity of middle ear", "cavitas tympani", "cavity of middle ear", "middle ear cavity", "middle-ear cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas tympanica", "tympanum" ; oboInOwl:id "UBERON:0004114" ; a owl:Class ; rdfs:label "tympanic cavity" ; rdfs:subClassOf obo:UBERON_0010064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0010063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001686 ], _:genid133273 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png"^^xsd:anyURI . obo:UBERON_0004115 obo:IAO_0000115 "A blood vessel that is part of a tympanic cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37775", "MA:0001219" ; oboInOwl:hasExactSynonym "anatomical cavity of middle ear blood vessel", "blood vessel of anatomical cavity of middle ear", "blood vessel of cavity of middle ear", "blood vessel of middle ear anatomical cavity", "blood vessel of middle ear cavity", "cavity of middle ear blood vessel", "middle ear anatomical cavity blood vessel", "middle ear blood vessel", "middle ear cavity blood vessel", "tympanic cavity blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004115" ; a owl:Class ; rdfs:label "blood vessel of tympanic cavity" ; rdfs:subClassOf obo:UBERON_0001981, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004114 ] ) ] . obo:UBERON_0004116 obo:IAO_0000115 "A nerve that is part of a tympanic cavity [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37777", "MA:0001222" ; oboInOwl:hasExactSynonym "anatomical cavity of middle ear nerve", "cavity of middle ear nerve", "middle ear anatomical cavity nerve", "middle ear cavity nerve", "nerve of anatomical cavity of middle ear", "nerve of cavity of middle ear", "nerve of middle ear anatomical cavity", "nerve of middle ear cavity", "tympanic cavity nerve", "tympanic cavity nerves" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004116" ; a owl:Class ; rdfs:label "nerve of tympanic cavity" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004114 ] ) ] . obo:UBERON_0004117 obo:IAO_0000115 "An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches." ; obo:UBPROP_0000001 "Outpocketings of pharyngeal endoderm that interdigitate with the neural crest derived pharyngeal arches. The pouches later fuse with the surface ectoderm to form the gill slits. Crump et al, 2004.[TAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000012 "EMAPA also includes a distinct pouch endoderm" ; oboInOwl:hasDbXref "AAO:0011113", "EFO:0003627", "EHDAA:1086", "EHDAA:1669", "EHDAA:579", "EHDAA:617", "EMAPA:32752", "FMA:293063", "NCIT:C34252", "SCTID:34674002", "TAO:0001106", "UMLS:C0231067", "VHOG:0001203", "Wikipedia:Pharyngeal_pouch_(embryology)", "XAO:0000282", "ZFA:0001106" ; oboInOwl:hasExactSynonym "branchial pouch", "visceral pouch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngeal pouches", "visceral pouches" ; oboInOwl:id "UBERON:0004117" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "The pouches are polarized structures. For example, whereas the rostral half of each pouch expresses Bmp-7, the caudal half expresses FGF-8 and the dorsal aspect of each pouch is marked via its expression of Pax-1. each pouch has an individual sense of identity. Shh expression is a prominent early feature of the caudal endoderm of the second arch, and individual pouches mark the anterior limits of expression of Hox genes within the pharyngeal endoderm; Hox-a2 has a rostral boundary at the second pouch, Hox-a3 at the third pouch and Hox-a4 at the most caudal pouch[PMID:16313389]" ; rdfs:label "pharyngeal pouch" ; rdfs:subClassOf obo:UBERON_0000490, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008814 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002539 ], _:genid133319 . obo:UBERON_0004118 obo:IAO_0000115 "A vasculature that is part of a iris [Automatically generated definition]." ; oboInOwl:hasDbXref "ZFA:0005568" ; oboInOwl:hasExactSynonym "iris blood vessels", "iris vascular network", "iris vasculature", "vascular network of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004118" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vasculature of iris" ; rdfs:subClassOf obo:UBERON_0002049 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) ] . obo:UBERON_0004119 obo:IAO_0000115 "An anatomical structure that develops (entirely or partially) from the endoderm." ; obo:IAO_0000232 "Grouping term for query purposes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004119" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "endoderm-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0004120 obo:IAO_0000115 "An anatomical structure that develops (entirely or partially) from the mesoderm." ; obo:IAO_0000232 "Grouping term for query purposes" ; oboInOwl:hasExactSynonym "mesodermal derivative" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004120" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "mesoderm-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ] . obo:UBERON_0004121 obo:IAO_0000115 "An anatomical structure that develops (entirely or partially) from the ectoderm." ; obo:IAO_0000232 "Grouping term for query purposes" ; oboInOwl:hasExactSynonym "ectodermal deriviative" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004121" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "ectoderm-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0004122 obo:IAO_0000115 "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." ; obo:UBPROP_0000001 "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.[AAO]" ; obo:UBPROP_0000002 "relationship type change: differentiates_from intermediate mesoderm (AAO:0010575) CHANGED TO: develops_from intermediate mesoderm (UBERON:0003064)[AAO]" ; obo:UBPROP_0000003 "Kidneys and gonads (of vertebrates) develop from adjacent tissues, and after the excretory or urinary ducts have developed, the reproductive system usually taps into them or their derivatives.[well established][VHOG]" ; obo:UBPROP_0000007 "genitourinary", "urogenital" ; oboInOwl:hasDbXref "AAO:0000624", "BILA:0000122", "BTO:0003091", "EFO:0003864", "EHDAA:1013", "EMAPA:16367", "EV:0100094", "FMA:280610", "GAID:362", "MESH:D014566", "NCIT:C12810", "SCTID:278861008", "UMLS:C0042066", "VHOG:0000286", "XAO:0000140", "galen:GenitoUrinarySystem" ; oboInOwl:hasExactSynonym "urogenital system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "GU tract", "UG tract", "Urogenitalsystem", "genito-urinary system", "genitourinary tract", "urogenital tract" ; oboInOwl:id "UBERON:0004122" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "genitourinary system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000990 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001008 ] ) ] . obo:UBERON_0004123 obo:IAO_0000115 "Any of the layers of the myocardium. Example: compact layer, trabecular layer." ; oboInOwl:hasDbXref "EMAPA:37475", "MA:0000080" ; oboInOwl:hasExactSynonym "layer of myocardium", "myocardium layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004123" ; oboInOwl:inSubset core:non_informative, core:pheno_slim ; a owl:Class ; rdfs:label "myocardial layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002349 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty core:layer_part_of ; owl:someValuesFrom obo:UBERON_0002349 ] ) ] . obo:UBERON_0004124 obo:IAO_0000115 "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." ; obo:UBPROP_0000001 "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the the endocardium. Unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae of the zebrafish have more strut-like character, and are more uniform without apparent regional differences Hu et al. 2001.[TAO]" ; oboInOwl:hasDbXref "EFO:0003706", "MA:0002866", "TAO:0005059", "ZFA:0005059" ; oboInOwl:hasExactSynonym "myocardial trabecular layer", "trabecular layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "heart muscle trabecula", "heart muscle trabeculae", "myocardial trabeculae carneae", "trabecula of heart muscle", "trabeculae" ; oboInOwl:id "UBERON:0004124" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "myocardium trabecular layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004123 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0036194 ] ) ] . obo:UBERON_0004126 obo:IAO_0000115 "A myocardium trabecular layer that is part of a cardiac ventricle." ; obo:IAO_0000116 "TODO - check FMA" ; oboInOwl:hasDbXref "FMA:83511", "TAO:0005060", "ZFA:0005060" ; oboInOwl:hasExactSynonym "myocardium of region of ventricle", "trabecular cardiac ventricle muscle", "ventricular trabecular myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004126" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "trabecular layer of ventricle" ; rdfs:subClassOf _:genid133393, _:genid133395 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004124 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0004128 obo:IAO_0000115 "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011039", "EHDAA2:0001320", "EMAPA:16540", "FMA:293357", "NCIT:C34236", "SCTID:362864008", "TAO:0000050", "UMLS:C0231106", "VHOG:0000165", "Wikipedia:Optic_vesicles", "XAO:0000228", "ZFA:0000050" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "evagination", "eye vesicle", "ocular vesicle", "optic vesicles" ; oboInOwl:id "UBERON:0004128" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 \"Developmental Biology\"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]" ; rdfs:label "optic vesicle" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0004880 ], _:genid133401, _:genid133403, _:genid133405 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png"^^xsd:anyURI . obo:UBERON_0004130 obo:IAO_0000115 "A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo." ; oboInOwl:hasDbXref "BIRNLEX:880", "EMAPA:35212", "FMA:83141", "MA:0000201", "NCIT:C49137", "SCTID:360478008", "UMLS:C1707522" ; oboInOwl:hasExactSynonym "cell layer of cerebellar cortex", "cytoarchitectural part of the cerebellar cortex", "gray matter layer of cerebellum", "layer of cerebellar cortex", "layer of cerebellum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004130" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebellar layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002129 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0004133 obo:IAO_0000115 "." ; oboInOwl:hasExactSynonym "salivary nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004133" ; a owl:Class ; rdfs:label "salivatory nucleus" ; rdfs:subClassOf obo:UBERON_0002308, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988 ] . obo:UBERON_0004139 obo:IAO_0000115 "The first recognizable structure derived from the heart field." ; obo:IAO_0000116 "TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO" ; obo:UBPROP_0000003 "(In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000215", "EMAPA:16106", "VHOG:0000975" ; oboInOwl:hasExactSynonym "myocardial plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac crescent", "cardiogenic crescent", "heart rudiment" ; oboInOwl:id "UBERON:0004139" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cardiogenic plate" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003084 ] . obo:UBERON_0004140 obo:IAO_0000115 "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." ; obo:UBPROP_0000012 "this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]" ; oboInOwl:hasDbXref "XAO:0004185" ; oboInOwl:hasExactSynonym "first heart field", "primary heart field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "FHF", "PHF", "heart field" ; oboInOwl:id "UBERON:0004140" ; a owl:Class ; rdfs:label "primary heart field" ; rdfs:subClassOf obo:UBERON_0007688, _:genid133434, _:genid133436 . obo:UBERON_0004141 obo:IAO_0000115 "An epithelial tube that will give rise to the mature heart." ; obo:UBPROP_0000001 "the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube." ; oboInOwl:hasDbXref "AAO:0010411", "EFO:0003526", "EMAPA:32685", "NCIT:C34161", "TAO:0000360", "XAO:0000337", "ZFA:0000360" ; oboInOwl:hasExactSynonym "embryonic heart tube", "endocardial heart tube", "endocardial tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004141" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "heart tube" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid133446 . obo:UBERON_0004142 obo:IAO_0000115 "The outflow tract septum is a partition in the outflow tract." ; oboInOwl:hasDbXref "XAO:0004141" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004142" ; a owl:Class ; rdfs:label "outflow tract septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002099 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 ] ) ] . obo:UBERON_0004145 obo:IAO_0000115 "The outflow tract is the portion of the heart through which blood flows into the arteries." ; obo:UBPROP_0000008 "Depending on the species, attached at the cardiac outflow are described the conus arteriosus, the truncus arteriosus and, or the bulbus arteriosus. At the distal limit of these outflow structures, but lying outside the pericardial cavity, is the ventral aorta[PMID:20735616]" ; oboInOwl:hasDbXref "EHDAA2:0001351", "EHDAA:464", "EHDAA:798", "EMAPA:16346", "MA:0000100", "VHOG:0000670", "XAO:0004139" ; oboInOwl:hasExactSynonym "cardiac outflow tract", "heart outflow tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arterial (outflow) pole" ; oboInOwl:id "UBERON:0004145" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "outflow tract" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0000178 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001637 ] . obo:UBERON_0004148 obo:IAO_0000115 "Vein of heart that drains the myocardium." ; oboInOwl:hasDbXref "EHDAA2:0004507", "EMAPA:37137", "FMA:12846", "NCIT:C12878", "NCIT:C12882", "SCTID:277726009", "UMLS:C0226654", "UMLS:C0226737", "Wikipedia:Coronary_circulation", "ZFA:0005814", "galen:CoronaryVein" ; oboInOwl:hasExactSynonym "cardiac vein", "coronary vein", "heart vein", "vein of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coronary vein" ; oboInOwl:id "UBERON:0004148" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cardiac vein" ; rdfs:subClassOf obo:UBERON_0013140 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002349 ] ) ] . obo:UBERON_0004151 obo:IAO_0000115 "A cardiac chamber surrounds an enclosed cavity within the heart." ; oboInOwl:hasDbXref "FMA:7095", "SCTID:276456008" ; oboInOwl:hasExactSynonym "chamber of heart", "heart chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004151" ; a owl:Class ; rdfs:comment "generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus" ; rdfs:label "cardiac chamber" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] . obo:UBERON_0004160 obo:IAO_0000115 "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." ; obo:UBPROP_0000007 "propepicardial" ; obo:UBPROP_0000008 "Proepicardial clusters in Zebrafish form on the pericardial wall, adjacent to the atrioventricular (AV) junction and near the venous pole[ZFA]" ; oboInOwl:hasDbXref "EMAPA:36025", "ZFA:0005808" ; oboInOwl:hasExactSynonym "proepicardial cluster", "proepicardial organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004160" ; a owl:Class ; rdfs:label "proepicardium" ; rdfs:subClassOf obo:UBERON_0003104, _:genid133483, _:genid133485 . obo:UBERON_0004161 obo:IAO_0000115 "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." ; obo:UBPROP_0000001 "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG]" ; obo:UBPROP_0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" ; obo:UBPROP_0000011 "The cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm. The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut." ; obo:UBPROP_0000012 "in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum" ; oboInOwl:hasDbXref "EHDAA2:0001829", "EHDAA:736", "EMAPA:16318", "FMA:295593", "NCIT:C34296", "SCTID:308819008", "UMLS:C0231004", "VHOG:0000019", "Wikipedia:Septum_transversum" ; oboInOwl:hasExactSynonym "transverse septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004161" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "septum transversum" ; rdfs:subClassOf obo:UBERON_0003104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ] . obo:UBERON_0004175 obo:IAO_0000115 "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." ; oboInOwl:hasDbXref "FMA:45652" ; oboInOwl:hasExactSynonym "internal genitalia", "internal genitals" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal reproductive organ", "internal sex organ" ; oboInOwl:id "UBERON:0004175" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "internal genitalia" ; rdfs:subClassOf obo:UBERON_0003133 . obo:UBERON_0004176 obo:IAO_0000115 "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." ; oboInOwl:hasDbXref "FMA:45643", "SCTID:362207005" ; oboInOwl:hasExactSynonym "external genitalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external reproductive organ", "external sex organ" ; oboInOwl:id "UBERON:0004176" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "external genitalia" ; rdfs:subClassOf obo:UBERON_0003133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ] . obo:UBERON_0004177 obo:IAO_0000115 "Organ that is part of the hematopoietic system." ; obo:IAO_0000116 "consider splitting out lymph organ, compare with lymph node" ; obo:UBPROP_0000001 "the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]." ; obo:UBPROP_0000012 "the FMA class 'lymphoid organ' is a general anatomical term" ; oboInOwl:hasDbXref "BTO:0004605", "EMAPA:37665", "FMA:7143", "MA:0000747", "SCTID:361338006" ; oboInOwl:hasExactSynonym "haematological system organ", "haemopoietic system organ", "hematopoeitic organ", "hematopoietic system organ", "organ of haematological system", "organ of haemopoietic system", "organ of hematopoietic system", "organ of organa haemopoietica", "organa haemopoietica organ" ; oboInOwl:hasNarrowSynonym "hematopoeitic or lymphoid organ", "lymph organ", "lymphoid organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004177" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "hemopoietic organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002390 ] ) ] . obo:UBERON_0004178 obo:IAO_0000115 "The nonstriated, involuntary muscle tissue located in the wall of the aorta." ; oboInOwl:hasDbXref "BTO:0001685", "CALOHA:TS-0048", "EFO:0002775", "EMAPA:35135", "MA:0000702", "NCIT:C49191", "UMLS:C1706825" ; oboInOwl:hasExactSynonym "aorta non-striated muscle", "aorta smooth muscle", "aortic smooth muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004178" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "aorta smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0004180 obo:IAO_0000115 "The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." ; oboInOwl:hasDbXref "EMAPA:35539", "MA:0002911" ; oboInOwl:hasExactSynonym "adipose tissue of lactiferous gland", "adipose tissue of mammary gland", "fat tissue of lactiferous gland", "fat tissue of lobe of breast", "fat tissue of lobe of mammary gland", "fat tissue of mammary gland", "fatty tissue of lactiferous gland", "fatty tissue of lobe of breast", "fatty tissue of lobe of mammary gland", "fatty tissue of mammary gland", "lactiferous gland adipose tissue", "lactiferous gland fat tissue", "lactiferous gland fatty tissue", "lobe of breast adipose tissue", "lobe of breast fat tissue", "lobe of breast fatty tissue", "lobe of mammary gland adipose tissue", "lobe of mammary gland fat tissue", "lobe of mammary gland fatty tissue", "mammary gland adipose tissue", "mammary gland fat tissue", "mammary gland fatty tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004180" ; a owl:Class ; rdfs:label "mammary gland fat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0004182 obo:IAO_0000115 "The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis." ; obo:UBPROP_0000008 "in female mouse embryos, the primary mammary cord (aka 'mammary sprout') is formed between E15.5 and E16.5; once the primary cord reaches the adipocytes of the fat pad (around E16), it begins to branch in a characteristic dichotomous fashion to form the initial ductal tree" ; oboInOwl:hasExactSynonym "lactiferous gland cord", "mammary cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary sprout" ; oboInOwl:id "UBERON:0004182" ; a owl:Class ; rdfs:label "mammary gland cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005154 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001765 ] ) ] . obo:UBERON_0004183 obo:IAO_0000115 "The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." ; oboInOwl:hasExactSynonym "blood vessel of labyrinthine layer", "blood vessel of labyrinthine layer of placenta", "blood vessel of placenta labyrinth", "labyrinthine layer blood vessel", "labyrinthine layer of placenta blood vessel", "placenta labyrinth blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004183" ; a owl:Class ; rdfs:label "placental labyrinth blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003970 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003946 ] ) ] . obo:UBERON_0004184 obo:IAO_0000115 "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." ; obo:IAO_0000116 "TODO - check also FMA Stroma of glandular part of prostate" ; oboInOwl:hasAlternativeId "UBERON:0005084" ; oboInOwl:hasDbXref "EMAPA:35714", "FMA:45719", "MA:0002912", "NCIT:C13104", "UMLS:C1521760" ; oboInOwl:hasExactSynonym "prostate stroma", "prostatic stroma", "stroma of prostate", "stroma of prostate gland" ; oboInOwl:hasNarrowSynonym "stroma of glandular part of prostate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004184" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "prostate gland stroma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0004185 obo:IAO_0000115 "A portions of the gut that is derived from endoderm." ; oboInOwl:hasDbXref "EMAPA:32930" ; oboInOwl:hasExactSynonym "endodermal gut", "gut endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004185" ; a owl:Class ; rdfs:label "endodermal part of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004921 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0004188 obo:IAO_0000115 "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." ; obo:IAO_0000116 "TODO - check - GO says outer, BTO says inner. Make this a superclass" ; oboInOwl:hasDbXref "BTO:0001515", "EMAPA:35458", "MA:0002847" ; oboInOwl:hasExactSynonym "epithelium of glomerulus", "epithelium of kidney glomerulus", "epithelium of renal glomerulus", "kidney glomerular epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glomerular epithelial cell" ; oboInOwl:id "UBERON:0004188" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "glomerular epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:UBERON_0004189 obo:IAO_0000115 "The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." ; oboInOwl:hasDbXref "BTO:0004631" ; oboInOwl:hasExactSynonym "endothelium of renal glomerulus", "renal glomerulus endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004189" ; a owl:Class ; rdfs:label "glomerular endothelium" ; rdfs:subClassOf obo:UBERON_0004188, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:UBERON_0004190 obo:IAO_0000115 "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." ; oboInOwl:hasExactSynonym "glomerulus vasculature", "renal glomerulus vascular network", "renal glomerulus vasculature", "vascular network of renal glomerulus", "vasculature of renal glomerulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004190" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "renal glomerulus vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid132428 ] . obo:UBERON_0004198 obo:IAO_0000115 "The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." ; oboInOwl:hasDbXref "EMAPA:27681", "ZFA:0005588" ; oboInOwl:hasExactSynonym "CSB" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004198" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "comma-shaped body" ; rdfs:subClassOf obo:UBERON_0005423, _:genid133617, _:genid133619 . obo:UBERON_0004199 obo:IAO_0000115 "The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." ; obo:IAO_0000116 "TODO" ; oboInOwl:hasDbXref "EMAPA:27756", "ZFA:0005589" ; oboInOwl:hasExactSynonym "SSB", "stage II nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004199" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "S-shaped body" ; rdfs:subClassOf obo:UBERON_0005423, _:genid133623, _:genid133625 . obo:UBERON_0004200 obo:IAO_0000115 "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." ; obo:UBPROP_0000012 "not the same as FMA:50609 Pyramid (which is a volume / dimensional entity)" ; obo:UBPROP_0000202 obo:FMA_74268 ; oboInOwl:hasAlternativeId "UBERON:0002449", "UBERON:0005098" ; oboInOwl:hasBroadSynonym "pyramid" ; oboInOwl:hasDbXref "BTO:0003926", "FMA:258870", "MA:0001654", "NCIT:C12886", "NCIT:C33436", "SCTID:361328001", "UMLS:C0227629", "UMLS:C1514613", "Wikipedia:Renal_pyramids" ; oboInOwl:hasExactSynonym "Malpighian pyramid", "renal pyramid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Malphigian pyramid", "Malpighian pyramid", "medullary pyramid", "pyramid of Malphigi", "pyramid of Malpighi", "pyramides renales", "pyramis renalis", "renal medullary region" ; oboInOwl:id "UBERON:0004200" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "kidney pyramid" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000362 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png"^^xsd:anyURI . obo:UBERON_0004203 obo:IAO_0000115 "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." ; oboInOwl:hasAlternativeId "UBERON:0005267" ; oboInOwl:hasDbXref "BTO:0002643", "EMAPA:28130", "MA:0002600" ; oboInOwl:hasExactSynonym "kidney cortex collecting duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renal cortex collecting duct" ; oboInOwl:id "UBERON:0004203" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cortical collecting duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:UBERON_0004205 obo:IAO_0000115 "The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." ; oboInOwl:hasAlternativeId "UBERON:0005187" ; oboInOwl:hasDbXref "BTO:0004544", "EMAPA:28370", "MA:0002598" ; oboInOwl:hasExactSynonym "inner renal medulla collecting duct", "kidney inner medulla collecting duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "papillary collecting duct" ; oboInOwl:id "UBERON:0004205" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inner medullary collecting duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001232 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ) ] . obo:UBERON_0004208 obo:IAO_0000115 "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." ; oboInOwl:hasExactSynonym "mesenchyme of nephron", "nephron mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004208" ; a owl:Class ; rdfs:comment "The detailed events associated with the differentiation of the nephrogenic mesenchyme are somewhat complex. It has been suggested that each terminal branch of the ureteric bud stimulates the associated cap mesenchyme tissue to form a renal vesicle (the most primitive stage of nephron development: a stage I nephron). This then elongates, becomes a comma-shaped and then an S-shaped body (stage II nephron), and makes contact with and fuses with the distal component of the ureteric bud. The latter then forms the collecting duct. One fold of the S-shaped body gives rise to Bowman's capsule (also termed the glomerular capsule). Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus. The inner epithelial layer of the Bowman's capsule (also called the visceral epithelium, or podocyte layer because it consists of podocytes) is closely apposed to the endothelial glomerulus. Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle. The rest of the nephron elongates to form components of the proximal tubule, the loop of Henle and the distal tubule. The distal pole of the developing nephron connects to the ureteric bud that induced it at an early stage of nephron/ collecting duct development, before differentiation of the proximal tubule, the loop of Henle and the distal tubule are complete. This connection allows the excretory products produced by the kidney to be removed and subsequently transferred, via the ureter, into the bladder where they are stored until it is appropriate to empty the bladder. [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron]" ; rdfs:label "nephrogenic mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001285 ] ) ] . obo:UBERON_0004209 obo:IAO_0000115 "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." ; obo:IAO_0000116 "note that this class includes both metanephric and mesonephric vesicles - ZFA and EHDAA2 associations are placed with these classes. TODO - make a more specific develops_from relationship - see UBERON:0005107 ! metanephric cap" ; oboInOwl:hasExactSynonym "stage I nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004209" ; a owl:Class ; rdfs:label "renal vesicle" ; rdfs:subClassOf obo:UBERON_0007503, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010536 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004208 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0000084 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0004211 ] . obo:UBERON_0004211 obo:IAO_0000115 "The nephron epithelium is a tissue that covers the surface of a nephron." ; oboInOwl:hasExactSynonym "epithelial tissue of nephron", "epithelium of nephron", "nephron epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004211" ; a owl:Class ; rdfs:label "nephron epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 ] ) ] . obo:UBERON_0004212 obo:IAO_0000115 "The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus." ; obo:UBPROP_0000001 "Capillary that is part of the renal glomerulus. Glomerular capillary endothelial membranes in zebrafish normally have a fenestrated morphology that is visible at the ultrastructural level.[TAO]" ; oboInOwl:hasDbXref "EMAPA:28245", "FMA:274259", "MA:0002587", "NCIT:C32684", "SCTID:362049007", "TAO:0005284", "UMLS:C0226356", "ZFA:0005284" ; oboInOwl:hasExactSynonym "blood capillary of renal glomerulus", "capillary of renal glomerulus", "capillary vessel of renal glomerulus", "renal glomerulus blood capillary", "renal glomerulus capillary", "renal glomerulus capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glomerular capillaries", "glomerular capillary system" ; oboInOwl:id "UBERON:0004212" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "glomerular capillary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0004639 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000074 ], _:genid133688 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] . obo:UBERON_0004214 obo:IAO_0000115 "A nerve that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37344", "MA:0000685" ; oboInOwl:hasExactSynonym "hind limb stylopod nerve", "hindlimb stylopod nerve", "lower extremity stylopod nerve", "thigh RELATED" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004214" ; a owl:Class ; rdfs:label "upper leg nerve" ; owl:equivalentClass _:genid132518 . obo:UBERON_0004215 obo:IAO_0000115 "A nerve that is part of a back [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37268", "MA:0000497" ; oboInOwl:hasExactSynonym "nerve of back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004215" ; a owl:Class ; rdfs:label "back nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0004216 obo:IAO_0000115 "A nerve that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37338", "MA:0000601" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004216" ; a owl:Class ; rdfs:label "lower arm nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0004217 obo:IAO_0000115 "A nerve that is part of a forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37337", "MA:0000607" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004217" ; a owl:Class ; rdfs:label "upper arm nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0004218 obo:IAO_0000115 "A nerve that is part of a lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37345", "MA:0000679" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004218" ; a owl:Class ; rdfs:label "lower leg nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid132548 ] . obo:UBERON_0004219 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36630", "FMA:76909", "MA:0001691" ; oboInOwl:hasExactSynonym "muscle layer of urethra", "muscular coat of urethra", "muscular layer of urethra", "smooth muscle of urethra", "smooth muscle tissue of urethra", "tunica muscularis urethrae", "urethra smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethral smooth muscle" ; oboInOwl:id "UBERON:0004219" ; a owl:Class ; rdfs:label "urethra smooth muscle layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0004220 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." ; obo:UBPROP_0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" ; oboInOwl:hasDbXref "EMAPA:35469", "MA:0001547" ; oboInOwl:hasExactSynonym "involuntary muscle of large intestine", "large intestine involuntary muscle", "large intestine non-striated muscle", "large intestine smooth muscle tissue", "non-striated muscle of large intestine", "smooth muscle of large intestine", "smooth muscle tissue of large intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004220" ; a owl:Class ; rdfs:label "large intestine smooth muscle" ; rdfs:subClassOf _:genid133755, _:genid133757 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0004221 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." ; obo:UBPROP_0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" ; oboInOwl:hasDbXref "BTO:0000643", "EMAPA:35441", "EMAPA:35443", "MA:0001539", "NCIT:C49243", "UMLS:C1708547" ; oboInOwl:hasExactSynonym "bowel involuntary muscle", "bowel non-striated muscle", "bowel smooth muscle", "bowel smooth muscle tissue", "intestine involuntary muscle", "intestine non-striated muscle", "intestine smooth muscle tissue", "involuntary muscle of bowel", "involuntary muscle of intestine", "non-striated muscle of bowel", "non-striated muscle of intestine", "smooth muscle of bowel", "smooth muscle of intestine", "smooth muscle tissue of bowel", "smooth muscle tissue of intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal muscularis", "intestinal smooth muscle" ; oboInOwl:id "UBERON:0004221" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "intestine smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001262 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000160 ], _:genid133773 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0004222 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001818", "EMAPA:35823", "MA:0001627" ; oboInOwl:hasExactSynonym "involuntary muscle of stomach", "involuntary muscle of ventriculus", "non-striated muscle of stomach", "non-striated muscle of ventriculus", "smooth muscle of stomach", "smooth muscle of ventriculus", "smooth muscle tissue of stomach", "smooth muscle tissue of ventriculus", "stomach involuntary muscle", "stomach non-striated muscle", "stomach smooth muscle tissue", "ventriculus involuntary muscle", "ventriculus non-striated muscle", "ventriculus smooth muscle", "ventriculus smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric muscle", "gastric smooth muscle", "stomach muscle" ; oboInOwl:id "UBERON:0004222" ; a owl:Class ; rdfs:label "stomach smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0004223 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004999", "EMAPA:30997", "MA:0001733" ; oboInOwl:hasExactSynonym "involuntary muscle of vagina", "non-striated muscle of vagina", "smooth muscle of vagina", "smooth muscle tissue of vagina", "vagina involuntary muscle", "vagina non-striated muscle", "vagina smooth muscle tissue", "vaginal smooth muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vagina smooth muscle" ; oboInOwl:id "UBERON:0004223" ; a owl:Class ; rdfs:label "vagina smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0004224 obo:IAO_0000115 "A muscular coat that is part of a vas deferens [Automatically generated definition]." ; obo:IAO_0000116 "TODO - check MA and FMA classes mean the same thing" ; oboInOwl:hasDbXref "EMAPA:29270", "FMA:19239", "MA:0001750", "SCTID:299705008" ; oboInOwl:hasExactSynonym "muscle layer of deferent duct", "muscle layer of ductus deferens", "muscle layer of vas deferens", "muscular coat of ductus deferens", "muscular layer of ductus deferens", "muscularis of vas deferens", "tunica muscularis (ductus deferens)", "tunica muscularis ductus deferentis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004224" ; a owl:Class ; rdfs:label "muscular coat of vas deferens" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001135 ] ; owl:equivalentClass _:genid132646 . obo:UBERON_0004225 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001660", "EMAPA:35734", "MA:0001830" ; oboInOwl:hasExactSynonym "respiratory smooth muscle", "smooth muscle of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "airway smooth muscle", "airway smooth muscle cell" ; oboInOwl:id "UBERON:0004225" ; a owl:Class ; rdfs:label "respiratory system smooth muscle" ; owl:equivalentClass _:genid132660 . obo:UBERON_0004226 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35117", "MA:0001523" ; oboInOwl:hasExactSynonym "smooth muscle tissue of gastrointestinal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004226" ; a owl:Class ; rdfs:label "gastrointestinal system smooth muscle" ; owl:equivalentClass _:genid132669 . obo:UBERON_0004227 obo:IAO_0000115 "The smooth muscle tissue surrounding the urothelium of the kidney pelvis." ; oboInOwl:hasDbXref "EMAPA:28120", "FMA:262022", "MA:0002631" ; oboInOwl:hasExactSynonym "kidney pelvis smooth muscle", "renal pelvis smooth muscle", "smooth muscle tissue of renal pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic smooth muscle" ; oboInOwl:id "UBERON:0004227" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney pelvis smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001224 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ) ] . obo:UBERON_0004228 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0001849", "CALOHA:TS-1087", "EMAPA:37791", "MA:0001697" ; oboInOwl:hasExactSynonym "bladder involuntary muscle", "bladder non-striated muscle", "bladder smooth muscle", "bladder smooth muscle tissue", "involuntary muscle of bladder", "involuntary muscle of urinary bladder", "non-striated muscle of bladder", "non-striated muscle of urinary bladder", "smooth muscle of bladder", "smooth muscle of urinary bladder", "smooth muscle tissue of bladder", "smooth muscle tissue of urinary bladder", "urinary bladder involuntary muscle", "urinary bladder muscle", "urinary bladder non-striated muscle", "urinary bladder smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "smooth muscle layer of bladder" ; oboInOwl:id "UBERON:0004228" ; a owl:Class ; rdfs:label "urinary bladder smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0004230 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:30123", "FMA:67990", "MA:0001699" ; oboInOwl:hasExactSynonym "bladder neck involuntary muscle", "bladder neck non-striated muscle", "bladder neck smooth muscle", "bladder neck smooth muscle tissue", "involuntary muscle of bladder neck", "involuntary muscle of neck of bladder", "involuntary muscle of neck of urinary bladder", "involuntary muscle of urinary bladder neck", "involuntary muscle of vesical neck", "neck of bladder involuntary muscle", "neck of bladder non-striated muscle", "neck of bladder smooth muscle", "neck of bladder smooth muscle tissue", "neck of urinary bladder involuntary muscle", "neck of urinary bladder non-striated muscle", "neck of urinary bladder smooth muscle", "neck of urinary bladder smooth muscle tissue", "non-striated muscle of bladder neck", "non-striated muscle of neck of bladder", "non-striated muscle of neck of urinary bladder", "non-striated muscle of urinary bladder neck", "non-striated muscle of vesical neck", "smooth muscle of bladder neck", "smooth muscle of neck of bladder", "smooth muscle of neck of urinary bladder", "smooth muscle of urinary bladder neck", "smooth muscle of vesical neck", "smooth muscle tissue of bladder neck", "smooth muscle tissue of neck of bladder", "smooth muscle tissue of neck of urinary bladder", "smooth muscle tissue of urinary bladder neck", "smooth muscle tissue of vesical neck", "trigonal muscle", "trigonal muscle of urinary bladder", "urinary bladder neck involuntary muscle", "urinary bladder neck muscle", "urinary bladder neck non-striated muscle", "urinary bladder neck smooth muscle tissue", "vesical neck involuntary muscle", "vesical neck non-striated muscle", "vesical neck smooth muscle", "vesical neck smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004230" ; a owl:Class ; rdfs:label "urinary bladder neck smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001258 ] ) ] . obo:UBERON_0004231 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37394", "MA:0001532" ; oboInOwl:hasExactSynonym "anal part of perineum involuntary muscle", "anal part of perineum non-striated muscle", "anal part of perineum smooth muscle", "anal part of perineum smooth muscle tissue", "anal region involuntary muscle", "anal region non-striated muscle", "anal region smooth muscle tissue", "anal triangle involuntary muscle", "anal triangle non-striated muscle", "anal triangle smooth muscle", "anal triangle smooth muscle tissue", "involuntary muscle of anal part of perineum", "involuntary muscle of anal region", "involuntary muscle of anal triangle", "non-striated muscle of anal part of perineum", "non-striated muscle of anal region", "non-striated muscle of anal triangle", "smooth muscle of anal part of perineum", "smooth muscle of anal region", "smooth muscle of anal triangle", "smooth muscle tissue of anal part of perineum", "smooth muscle tissue of anal region", "smooth muscle tissue of anal triangle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004231" ; a owl:Class ; rdfs:label "anal region smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] ) ] . obo:UBERON_0004232 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36313", "FMA:262026", "MA:0000751", "NCIT:C49260", "UMLS:C1708791" ; oboInOwl:hasExactSynonym "involuntary muscle of lymph vessel", "involuntary muscle of lymphatic vessel", "lymph vessel involuntary muscle", "lymph vessel non-striated muscle", "lymph vessel smooth muscle", "lymph vessel smooth muscle tissue", "lymphatic vessel involuntary muscle", "lymphatic vessel non-striated muscle", "lymphatic vessel smooth muscle tissue", "non-striated muscle of lymph vessel", "non-striated muscle of lymphatic vessel", "smooth muscle of lymph vessel", "smooth muscle of lymphatic vessel", "smooth muscle tissue of lymph vessel", "smooth muscle tissue of lymphatic vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004232" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lymphatic vessel smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:UBERON_0004233 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35520", "MA:0002410" ; oboInOwl:hasExactSynonym "involuntary muscle of lower respiratory tract", "lower respiratory tract involuntary muscle", "lower respiratory tract non-striated muscle", "lower respiratory tract smooth muscle tissue", "non-striated muscle of lower respiratory tract", "smooth muscle of lower respiratory tract", "smooth muscle tissue of lower respiratory tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004233" ; a owl:Class ; rdfs:label "lower respiratory tract smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] . obo:UBERON_0004234 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." ; obo:IAO_0000116 "see notes for muscle of iris." ; oboInOwl:hasDbXref "BTO:0000655", "EMAPA:35448", "FMA:312338", "MA:0001270" ; oboInOwl:hasExactSynonym "involuntary muscle of iris", "iridial smooth muscle", "iris involuntary muscle", "iris non-striated muscle", "iris smooth muscle tissue", "non-striated muscle of iris", "smooth muscle of iris", "smooth muscle tissue of iris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004234" ; a owl:Class ; rdfs:label "iris smooth muscle" ; rdfs:subClassOf obo:UBERON_0003386, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001606 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid132818 ] . obo:UBERON_0004235 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37669", "MA:0000795" ; oboInOwl:hasExactSynonym "smooth muscle tissue of mammary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004235" ; a owl:Class ; rdfs:label "mammary gland smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0004236 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36287", "FMA:312251", "MA:0000706" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004236" ; a owl:Class ; rdfs:label "arteriole smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001980 ] ) ] . obo:UBERON_0004237 obo:IAO_0000115 "Smooth muscle found within, and composing the majority of the wall of blood vessels." ; obo:UBPROP_0000009 "Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension." ; oboInOwl:hasAlternativeId "UBERON:0010508" ; oboInOwl:hasDbXref "BTO:0001431", "CALOHA:TS-1107", "EMAPA:35177", "MA:0000710", "MESH:D009131", "NCIT:C33853", "TAO:0005321", "UMLS:C1519956", "Wikipedia:Vascular_smooth_muscle", "ZFA:0005321" ; oboInOwl:hasExactSynonym "blood vessel involuntary muscle", "blood vessel non-striated muscle", "blood vessel smooth muscle tissue", "involuntary muscle of blood vessel", "non-striated muscle of blood vessel", "smooth muscle of blood vessel", "smooth muscle tissue of blood vessel", "vascular smooth muscle", "vascular smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004237" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "blood vessel smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0004238 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35807", "MA:0000757" ; oboInOwl:hasExactSynonym "involuntary muscle of spleen", "non-striated muscle of spleen", "smooth muscle of spleen", "smooth muscle tissue of spleen", "spleen involuntary muscle", "spleen non-striated muscle", "spleen smooth muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004238" ; a owl:Class ; rdfs:label "spleen smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0004239 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." ; obo:UBPROP_0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" ; oboInOwl:hasDbXref "EMAPA:35783", "MA:0001559" ; oboInOwl:hasExactSynonym "involuntary muscle of small bowel", "involuntary muscle of small intestine", "non-striated muscle of small bowel", "non-striated muscle of small intestine", "small bowel involuntary muscle", "small bowel non-striated muscle", "small bowel smooth muscle", "small bowel smooth muscle tissue", "small intestine involuntary muscle", "small intestine non-striated muscle", "small intestine smooth muscle tissue", "smooth muscle of small bowel", "smooth muscle of small intestine", "smooth muscle tissue of small bowel", "smooth muscle tissue of small intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004239" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "small intestine smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168 ], _:genid134063 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0004240 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35373", "MA:0001635", "NCIT:C49483", "UMLS:C1708179" ; oboInOwl:hasExactSynonym "gall bladder involuntary muscle", "gall bladder non-striated muscle", "gall bladder smooth muscle", "gall bladder smooth muscle tissue", "gallbladder involuntary muscle", "gallbladder non-striated muscle", "gallbladder smooth muscle tissue", "involuntary muscle of gall bladder", "involuntary muscle of gallbladder", "non-striated muscle of gall bladder", "non-striated muscle of gallbladder", "smooth muscle of gall bladder", "smooth muscle of gallbladder", "smooth muscle tissue of gall bladder", "smooth muscle tissue of gallbladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary smooth muscle" ; oboInOwl:id "UBERON:0004240" ; a owl:Class ; rdfs:label "gallbladder smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0004242 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004401", "EMAPA:35195", "MA:0001840", "NCIT:C49213", "UMLS:C1707055" ; oboInOwl:hasExactSynonym "bronchi involuntary muscle", "bronchi non-striated muscle", "bronchi smooth muscle", "bronchi smooth muscle tissue", "bronchial trunk involuntary muscle", "bronchial trunk non-striated muscle", "bronchial trunk smooth muscle", "bronchial trunk smooth muscle tissue", "bronchus involuntary muscle", "bronchus non-striated muscle", "bronchus smooth muscle tissue", "involuntary muscle of bronchi", "involuntary muscle of bronchial trunk", "involuntary muscle of bronchus", "non-striated muscle of bronchi", "non-striated muscle of bronchial trunk", "non-striated muscle of bronchus", "smooth muscle of bronchi", "smooth muscle of bronchial trunk", "smooth muscle of bronchus", "smooth muscle tissue of bronchi", "smooth muscle tissue of bronchial trunk", "smooth muscle tissue of bronchus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchial smooth muscle" ; oboInOwl:id "UBERON:0004242" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchus smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0004243 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0003159", "EMAPA:35713", "FMA:74245", "MA:0001741" ; oboInOwl:hasExactSynonym "involuntary muscle of prostate", "involuntary muscle of prostate gland", "muscular tissue of prostate", "non-striated muscle of prostate", "non-striated muscle of prostate gland", "prostate gland involuntary muscle", "prostate gland non-striated muscle", "prostate gland smooth muscle tissue", "prostate involuntary muscle", "prostate non-striated muscle", "prostate smooth muscle", "prostate smooth muscle tissue", "smooth muscle of prostate", "smooth muscle of prostate gland", "smooth muscle tissue of prostate", "smooth muscle tissue of prostate gland", "substantia muscularis prostatae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004243" ; a owl:Class ; rdfs:label "prostate gland smooth muscle" ; rdfs:subClassOf _:genid134137 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 _:genid132946 ) ] . obo:UBERON_0004245 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:29046", "MA:0001721" ; oboInOwl:hasExactSynonym "fallopian tube involuntary muscle", "fallopian tube non-striated muscle", "fallopian tube smooth muscle", "fallopian tube smooth muscle tissue", "involuntary muscle of fallopian tube", "non-striated muscle of fallopian tube", "smooth muscle of fallopian tube", "smooth muscle tissue of fallopian tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004245" ; a owl:Class ; rdfs:label "oviduct smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_0004246 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37708", "MA:0000492" ; oboInOwl:hasExactSynonym "involuntary muscle of outflow tract", "non-striated muscle of outflow tract", "outflow tract involuntary muscle", "outflow tract non-striated muscle", "outflow tract smooth muscle tissue", "smooth muscle of outflow tract", "smooth muscle tissue of outflow tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004246" ; a owl:Class ; rdfs:label "outflow tract smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 ] ) ] . obo:UBERON_0004247 obo:IAO_0000115 "A bone that is part of the dorsal region of an animal." ; obo:IAO_0000232 "this class may be obsoleted. See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/93" ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37248", "MA:0000494" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "back bone", "bone of back", "dorsal region bone" ; oboInOwl:id "UBERON:0004247" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "bone of dorsum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0004248 obo:IAO_0000115 "A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37309", "MA:0000646" ; oboInOwl:hasExactSynonym "bone of digit of foot", "digit of foot bone", "digital bone of foot", "digital bone of pes", "digitus pedis bone", "digitus pedis bone organ", "foot digit bone", "foot digit bone organ", "hind limb digit bone", "toe bone", "toe bone organ" ; oboInOwl:hasNarrowSynonym "foot digit bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004248" ; a owl:Class ; rdfs:label "pedal digit bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101466 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0004249 obo:IAO_0000115 "A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37305", "MA:0000622" ; oboInOwl:hasExactSynonym "digital bone of hand", "digital bone of manus", "finger bone", "fore limb digit bone", "hand digit bone" ; oboInOwl:hasNarrowSynonym "hand digit bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004249" ; a owl:Class ; rdfs:label "manual digit bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0004250 obo:IAO_0000115 "A bone that is part of a forelimb stylopod [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:35892", "MA:0000604" ; oboInOwl:hasNarrowSynonym "humerus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004250" ; a owl:Class ; rdfs:comment "May be merged into humerus. See: https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; rdfs:label "upper arm bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0004251 obo:IAO_0000115 "A bone that is part of a lower leg [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:35519", "MA:0000676" ; oboInOwl:hasExactSynonym "bone of hind limb middle limb segment", "bone of hind limb zeugopod", "bone of hindlimb middle limb segment", "bone of hindlimb zeugopod", "bone of inferior member middle limb segment", "bone of inferior member zeugopod", "bone of intermediate segment of free lower limb", "bone of lower extremity middle limb segment", "bone of lower extremity zeugopod", "bone of lower leg", "bone of middle limb segment of hind limb", "bone of middle limb segment of hindlimb", "bone of middle limb segment of inferior member", "bone of middle limb segment of lower extremity", "bone of zeugopod of hind limb", "bone of zeugopod of hindlimb", "bone of zeugopod of inferior member", "bone of zeugopod of leg", "bone of zeugopod of lower extremity", "bone organ of hind limb middle limb segment", "bone organ of hind limb zeugopod", "bone organ of hindlimb middle limb segment", "bone organ of hindlimb zeugopod", "bone organ of inferior member middle limb segment", "bone organ of inferior member zeugopod", "bone organ of intermediate segment of free lower limb", "bone organ of lower extremity middle limb segment", "bone organ of lower extremity zeugopod", "bone organ of lower leg", "bone organ of middle limb segment of hind limb", "bone organ of middle limb segment of hindlimb", "bone organ of middle limb segment of inferior member", "bone organ of middle limb segment of lower extremity", "bone organ of zeugopod of hind limb", "bone organ of zeugopod of hindlimb", "bone organ of zeugopod of inferior member", "bone organ of zeugopod of leg", "bone organ of zeugopod of lower extremity", "hind limb middle limb segment bone", "hind limb middle limb segment bone organ", "hind limb zeugopod bone", "hind limb zeugopod bone organ", "hindlimb middle limb segment bone", "hindlimb middle limb segment bone organ", "hindlimb zeugopod bone", "hindlimb zeugopod bone organ", "inferior member middle limb segment bone", "inferior member middle limb segment bone organ", "inferior member zeugopod bone", "inferior member zeugopod bone organ", "intermediate segment of free lower limb bone", "intermediate segment of free lower limb bone organ", "lower extremity middle limb segment bone", "lower extremity middle limb segment bone organ", "lower extremity zeugopod bone", "lower extremity zeugopod bone organ", "lower leg bone", "middle limb segment of hind limb bone", "middle limb segment of hind limb bone organ", "middle limb segment of hindlimb bone", "middle limb segment of hindlimb bone organ", "middle limb segment of inferior member bone", "middle limb segment of inferior member bone organ", "middle limb segment of lower extremity bone", "middle limb segment of lower extremity bone organ", "zeugopod of hind limb bone", "zeugopod of hind limb bone organ", "zeugopod of hindlimb bone", "zeugopod of hindlimb bone organ", "zeugopod of inferior member bone", "zeugopod of inferior member bone organ", "zeugopod of leg bone", "zeugopod of leg bone organ", "zeugopod of lower extremity bone", "zeugopod of lower extremity bone organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004251" ; a owl:Class ; rdfs:label "hindlimb zeugopod bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0004252 obo:IAO_0000115 "Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0000374" ; oboInOwl:hasDbXref "BTO:0001367", "EMAPA:19144", "FMA:22470", "MA:0000684", "SCTID:245013005" ; oboInOwl:hasExactSynonym "muscle of thigh", "thigh muscle", "upper leg muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004252" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hindlimb stylopod muscle" ; rdfs:subClassOf _:genid134310 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0004253 obo:IAO_0000115 "Any muscle organ that is part of a skin of body [Automatically generated definition]." ; obo:IAO_0000116 "review as part of general integumentary system review - part of skin, or more generally, integumental system" ; obo:UBPROP_0000012 "in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only" ; oboInOwl:hasAlternativeId "UBERON:0015797" ; oboInOwl:hasDbXref "EMAPA:18187", "EMAPA:35776", "MA:0002710", "MA:0003139" ; oboInOwl:hasExactSynonym "integumental system muscle", "muscle of integumental system", "muscle organ of skin", "skin muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004253" ; a owl:Class ; rdfs:label "skin muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002097 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] ) ] . obo:UBERON_0004254 obo:IAO_0000115 "Any muscle organ that is part of a forelimb zeugopod (lower arm)[Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32622", "FMA:37371", "MA:0000600", "SCTID:181631004" ; oboInOwl:hasExactSynonym "forearm muscle", "lower arm muscle", "muscle of forearm" ; oboInOwl:hasNarrowSynonym "wing zeugopod muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004254" ; a owl:Class ; rdfs:label "forelimb zeugopod muscle" ; rdfs:subClassOf _:genid134331 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0004255 obo:IAO_0000115 "Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition]." ; obo:IAO_0000116 "the FMA class 'muscle of arm' belongs here, do not move" ; obo:UBPROP_0000013 "See notes on UBERON:0001460 for possible terminological confusion over term 'arm'" ; oboInOwl:hasDbXref "EMAPA:19107", "FMA:37370", "MA:0000606", "SCTID:244979005" ; oboInOwl:hasExactSynonym "muscle of upper arm", "upper arm muscle" ; oboInOwl:hasNarrowSynonym "wing stylopod muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle of arm", "skeletal muscle of upper arm" ; oboInOwl:id "UBERON:0004255" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "forelimb stylopod muscle" ; rdfs:subClassOf _:genid134342 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0004256 obo:IAO_0000115 "Any muscle organ that is part of a hindlimb zeugopod (lower leg) [Automatically generated definition]." ; obo:IAO_0000116 "the FMA class 'muscle of leg' belongs here, do not move[cjm]" ; obo:UBPROP_0000013 "See notes on UBERON:0000978 for possible terminological confusion over term 'leg'" ; oboInOwl:hasDbXref "EMAPA:19318", "FMA:22471", "MA:0000678", "SCTID:265806001" ; oboInOwl:hasExactSynonym "lower leg muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calf muscle", "muscle of leg" ; oboInOwl:id "UBERON:0004256" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hindlimb zeugopod muscle" ; rdfs:subClassOf _:genid134354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0004257 obo:IAO_0000115 "A blood vessel that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37299", "MA:0000681" ; oboInOwl:hasExactSynonym "blood vessel of stylopod of hind limb", "blood vessel of stylopod of hindlimb", "blood vessel of thigh", "blood vessel of upper leg", "hind limb stylopod blood vessel", "hindlimb stylopod blood vessel", "thigh blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004257" ; a owl:Class ; rdfs:label "upper leg blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0004258 obo:IAO_0000115 "A blood vessel that is part of a back [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37243", "MA:0000493" ; oboInOwl:hasExactSynonym "blood vessel of back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004258" ; a owl:Class ; rdfs:label "back blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0004259 obo:IAO_0000115 "A blood vessel that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37295", "MA:0000597" ; oboInOwl:hasExactSynonym "forelimb zeugopod blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004259" ; a owl:Class ; rdfs:label "lower arm blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0004260 obo:IAO_0000115 "A blood vessel that is part of a forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37294", "MA:0000603" ; oboInOwl:hasExactSynonym "forelimb stylopod blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004260" ; a owl:Class ; rdfs:label "upper arm blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0004261 obo:IAO_0000115 "A blood vessel that is part of a lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37300", "MA:0000675" ; oboInOwl:hasExactSynonym "hindlimb zeugopod blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004261" ; a owl:Class ; rdfs:label "lower leg blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0004262 obo:IAO_0000115 "A zone of skin that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18159", "FMA:37790", "MA:0000686", "SCTID:181547006" ; oboInOwl:hasExactSynonym "hind limb stylopod skin", "hindlimb stylopod skin", "skin of upper leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin of thigh", "thigh skin" ; oboInOwl:id "UBERON:0004262" ; a owl:Class ; rdfs:label "upper leg skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0004263 obo:IAO_0000115 "A zone of skin that is part of a forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18062", "FMA:37721", "MA:0000608", "SCTID:181531009" ; oboInOwl:hasExactSynonym "arm stylopod skin", "skin of arm stylopod", "skin of upper arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004263" ; a owl:Class ; rdfs:label "upper arm skin" ; owl:equivalentClass _:genid133217 . obo:UBERON_0004264 obo:IAO_0000115 "A zone of skin that is part of a lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18156", "MA:0000680", "SCTID:244180007" ; oboInOwl:hasExactSynonym "hind limb middle limb segment skin", "hind limb zeugopod skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004264" ; a owl:Class ; rdfs:label "lower leg skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0004265 obo:IAO_0000115 "A myocardium that is part of a outflow tract [Automatically generated definition]." ; obo:UBPROP_0000003 "(...) (theme) is how the vertebrate cardiovascular system differs from that of the presumptive evolutionary chordate ancestor. (...) At best we can tell there are two essential new ingredients: (1) vertebrates all have a continuous endothelial lining to the heart and vessels and (2) vertebrates have developed a second chamber in the heart, one designed for generating high systemic blood pressure.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001358", "EMAPA:35623", "MA:0000489", "VHOG:0000603" ; oboInOwl:hasExactSynonym "cardiac muscle of outflow tract", "heart muscle of outflow tract", "heart myocardium of outflow tract", "muscle of heart of outflow tract", "myocardium of outflow tract", "outflow tract cardiac muscle", "outflow tract heart muscle", "outflow tract heart myocardium", "outflow tract muscle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004265" ; a owl:Class ; rdfs:label "outflow tract myocardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 ] ) ] . obo:UBERON_0004266 obo:IAO_0000115 "A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37325", "MA:0000683" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004266" ; a owl:Class ; rdfs:label "upper leg connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0004267 obo:IAO_0000115 "A portion of connective tissue that is part of a back [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37256", "MA:0000495" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesenchyne of back" ; oboInOwl:id "UBERON:0004267" ; a owl:Class ; rdfs:label "back connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0004268 obo:IAO_0000115 "A portion of connective tissue that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37319", "MA:0000599" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004268" ; a owl:Class ; rdfs:label "lower arm connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003327 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0004269 obo:IAO_0000115 "A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37317", "MA:0000605" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004269" ; a owl:Class ; rdfs:label "upper arm connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005258 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0004270 obo:IAO_0000115 "A portion of connective tissue that is part of a lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37327", "MA:0000677" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004270" ; a owl:Class ; rdfs:label "lower leg connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005259 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0004271 obo:IAO_0000115 "A pericardium that is part of a outflow tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37707", "MA:0000491" ; oboInOwl:hasExactSynonym "pericardium of outflow tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004271" ; a owl:Class ; rdfs:label "outflow tract pericardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002407 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 ] ) ] . obo:UBERON_0004273 obo:IAO_0000115 "A cranial suture that is part of a cartilaginous joint [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37463", "MA:0001498" ; oboInOwl:hasExactSynonym "articulatio cartilaginea cranial suture", "articulatio cartilaginea cranial sutures", "articulatio cartilaginea cranial sutures set", "articulatio cartilaginea cranium suture", "articulatio cartilaginea suture of cranium", "cartilaginous joint cranial suture", "cartilaginous joint cranial sutures", "cartilaginous joint cranial sutures set", "cartilaginous joint cranium suture", "cartilaginous joint suture of cranium", "cranial suture of articulatio cartilaginea", "cranial suture of cartilaginous joint", "cranial sutures of articulatio cartilaginea", "cranial sutures of cartilaginous joint", "cranial sutures set of articulatio cartilaginea", "cranial sutures set of cartilaginous joint", "cranium suture of articulatio cartilaginea", "cranium suture of cartilaginous joint", "suture of cranium of articulatio cartilaginea", "suture of cranium of cartilaginous joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004273" ; a owl:Class ; rdfs:label "cartilaginous joint suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002213 ] ) ] . obo:UBERON_0004274 obo:IAO_0000115 "A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0004450", "FMA:242815", "MA:0000962", "NCIT:C49248", "UMLS:C1711323" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle", "chorioid plexus of cerebral hemisphere epithelium of lateral ventricle", "choroid plexus epithelial tissue of lateral ventricle", "choroid plexus epithelium of lateral ventricle", "epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle", "epithelial tissue of choroid plexus of lateral ventricle", "epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle", "epithelium of choroid plexus of lateral ventricle", "lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue", "lateral ventricle chorioid plexus of cerebral hemisphere epithelium", "lateral ventricle choroid plexus epithelial tissue", "lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere", "lateral ventricle epithelial tissue of choroid plexus", "lateral ventricle epithelium of chorioid plexus of cerebral hemisphere", "lateral ventricle epithelium of choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004274" ; a owl:Class ; rdfs:label "lateral ventricle choroid plexus epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002307 ] ) ] . obo:UBERON_0004275 obo:IAO_0000115 "A choroid plexus epithelium that is part of a third ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37055", "FMA:242821", "MA:0000880" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere epithelial tissue of third ventricle", "chorioid plexus of cerebral hemisphere epithelium of third ventricle", "choroid plexus epithelial tissue of third ventricle", "choroid plexus epithelium of third ventricle", "epithelial tissue of chorioid plexus of cerebral hemisphere of third ventricle", "epithelial tissue of choroid plexus of third ventricle", "epithelium of chorioid plexus of cerebral hemisphere of third ventricle", "epithelium of choroid plexus of third ventricle", "third ventricle chorioid plexus of cerebral hemisphere epithelial tissue", "third ventricle chorioid plexus of cerebral hemisphere epithelium", "third ventricle choroid plexus epithelial tissue", "third ventricle epithelial tissue of chorioid plexus of cerebral hemisphere", "third ventricle epithelial tissue of choroid plexus", "third ventricle epithelium of chorioid plexus of cerebral hemisphere", "third ventricle epithelium of choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004275" ; a owl:Class ; rdfs:label "third ventricle choroid plexus epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002288 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ) ] . obo:UBERON_0004276 obo:IAO_0000115 "A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:242823", "MA:0000984", "NCIT:C49230", "UMLS:C1707392" ; oboInOwl:hasExactSynonym "chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle", "chorioid plexus of cerebral hemisphere epithelium of fourth ventricle", "choroid plexus epithelial tissue of fourth ventricle", "choroid plexus epithelium of fourth ventricle", "epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle", "epithelial tissue of choroid plexus of fourth ventricle", "epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle", "epithelium of choroid plexus of fourth ventricle", "fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue", "fourth ventricle chorioid plexus of cerebral hemisphere epithelium", "fourth ventricle choroid plexus epithelial tissue", "fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere", "fourth ventricle epithelial tissue of choroid plexus", "fourth ventricle epithelium of chorioid plexus of cerebral hemisphere", "fourth ventricle epithelium of choroid plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004276" ; a owl:Class ; rdfs:label "fourth ventricle choroid plexus epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) ] . obo:UBERON_0004277 obo:IAO_0000115 "A muscle that is part of the eye region." ; oboInOwl:hasDbXref "AAO:0000156", "EMAPA:35335", "MA:0000271" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004277" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "eye muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid134578 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0004288 obo:IAO_0000115 "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." ; obo:RO_0002171 obo:UBERON_0000383 ; obo:UBPROP_0000001 "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO]" ; obo:UBPROP_0000007 "skeletal" ; oboInOwl:hasDbXref "AEO:0000168", "EHDAA2:0001843", "EHDAA:5047", "EMAPA:17213", "FMA:23875", "GAID:177", "MA:0003006", "MAT:0000032", "MESH:D012863", "MIAA:0000032", "SCTID:361378004", "VSAO:0000026", "Wikipedia:Skeleton", "XAO:0004053", "galen:Skeleton" ; oboInOwl:hasExactSynonym "set of all bones", "set of bones of body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004288" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "skeleton" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/The-skeletal-system"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0034925, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0004765 ] ; owl:disjointWith obo:UBERON_0004770 . obo:UBERON_0004290 obo:IAO_0000115 "The bilaminar epithelium formed from the myotome and dermatome." ; obo:UBPROP_0000001 "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768].", "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]", "Portion of somites that gives rise to dermis and muscles.[AAO]", "all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis." ; obo:UBPROP_0000003 "Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010572", "AEO:0000214", "EHDAA2:0003259", "EMAPA:31109", "FMA:295654", "NCIT:C34140", "TAO:0001513", "UMLS:C1511786", "VHOG:0000676", "ZFA:0001513" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermamyotome", "dermomyotomes" ; oboInOwl:id "UBERON:0004290" ; a owl:Class ; rdfs:label "dermomyotome" ; rdfs:subClassOf obo:UBERON_0000486, obo:UBERON_0016888, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000075 ], _:genid134589 . obo:UBERON_0004291 obo:IAO_0000115 "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." ; obo:UBPROP_0000001 "The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO]" ; oboInOwl:hasDbXref "TAO:0000115", "ZFA:0000115" ; oboInOwl:hasExactSynonym "heart cone", "rudimentary heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004291" ; a owl:Class ; rdfs:label "heart rudiment" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004139 ], _:genid134600 . obo:UBERON_0004292 obo:IAO_0000115 "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." ; obo:UBPROP_0000009 "It is not a true skeleton, but it does provide structure and support for the heart, as well as isolating the atria from the ventricles. This allows the AV node and AV bundle to delay the wave of depolarisation such that the atria can contract and assist in ventricular filling before the ventricles themselves depolarise and contract (the AV bundle is the only part of the conduction system that passes from the atria to the ventricles in a normal heart). It also allows the valves (bicuspid, tricuspid, semilunar) to keep open by giving them structural support[WP]" ; oboInOwl:hasDbXref "EMAPA:36645", "FMA:9496", "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasExactSynonym "cardiac fibrous skeleton", "fibrous skeleton of heart", "heart fibrous skeleton", "skeleton of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anulus fibrosus dexter cordis", "anulus fibrosus sinister cordis", "trigona fibrosa", "trigonum fibrosum dextrum cordis", "trigonum fibrosum sinistrum cordis" ; oboInOwl:id "UBERON:0004292" ; a owl:Class ; rdfs:label "cardiac skeleton" ; rdfs:subClassOf obo:UBERON_0002384, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002082 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png"^^xsd:anyURI . obo:UBERON_0004293 obo:IAO_0000115 "A nerve that is part of a parasympathetic nervous system [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001401", "EMAPA:17271", "MA:0000224", "SCTID:276146002", "VHOG:0000641" ; oboInOwl:hasExactSynonym "nerve of parasympathetic nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004293" ; a owl:Class ; rdfs:label "parasympathetic nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001808 ], _:genid134623, _:genid134625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000011 ] ) ] . obo:UBERON_0004294 obo:IAO_0000115 "An endothelium that is part of a glomerular capillary." ; oboInOwl:hasDbXref "MA:0001658", "NCIT:C32522", "SCTID:243993006", "UMLS:C0227647" ; oboInOwl:hasExactSynonym "renal glomerulus capillary endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004294" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "glomerular capillary endothelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004212 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004212 ] ) ] . obo:UBERON_0004295 obo:IAO_0000115 "A nerve trunk that is part of a sympathetic nervous system [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001970", "EMAPA:35845", "MA:0000227" ; oboInOwl:hasExactSynonym "nerve trunk of sympathetic nervous system", "nerve trunk of sympathetic part of autonomic division of nervous system", "sympathetic nervous system nerve trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004295" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sympathetic nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000013 ] ) ] . obo:UBERON_0004296 obo:IAO_0000115 "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37582", "MA:0001826" ; oboInOwl:hasExactSynonym "smooth muscle of lymph vessel of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004296" ; a owl:Class ; rdfs:label "respiratory system lymphatic vessel smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003456 ] ) ] . obo:UBERON_0004297 obo:IAO_0000115 "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37573", "MA:0001806" ; oboInOwl:hasExactSynonym "smooth muscle tissue of blood vessel of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004297" ; a owl:Class ; rdfs:label "respiratory system blood vessel smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003504 ] ) ] . obo:UBERON_0004300 obo:IAO_0000115 "Distal-most phalanx within a digit." ; obo:UBPROP_0000008 "In human anatomy, the distal phalanges of the four fingers and toes articulate proximally with the intermediate phalanges at the distal interphalangeal joints (DIP); in the thumb and big toe, with only two phalanges, the distal phalanges articulate proximally with the proximal phalanges. The distal phalanges carry and shape nails and claws and are therefore occasionally referred to as the ungual phalanges. The distal phalanges are cone-shaped in most mammals, including most primates, but relatively wide and flat in humans." ; oboInOwl:hasDbXref "AAO:0010676", "EMAPA:35287", "MA:0002914", "SCTID:299711006", "Wikipedia:Distal_phalanges" ; oboInOwl:hasExactSynonym "phalanx distalis", "terminal phalanx", "ungual phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "phalanx distalis" ; oboInOwl:id "UBERON:0004300" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009551 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0004301 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Scheme_human_hand_bones-en.svg"^^xsd:anyURI . obo:UBERON_0004301 obo:IAO_0000115 "A phalanx located between proximal and distal phalanges." ; obo:IAO_0000116 "consider using numbering system, and axioms to the effect that there is a single middle phalanx per finger in humans. This should perhaps be renamed 'intermediate phalanx', leaving the term middle phalanx open for the specific intermediate phalanx of a 3-phalanx digit" ; obo:UBPROP_0000008 "Intermediate phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones of the finger and toe which lie in the middle, between the two wrinkly joints. The thumb and big toe do not have intermediate phalanges. In most other vertebrates, they have a corresponding place in their limbs, whether they be paw, wing, hoof or fin", "in some groups such as whales, there are multiple intermediate phalanges" ; oboInOwl:hasDbXref "AAO:0010677", "EMAPA:35572", "MA:0002915", "SCTID:299710007", "Wikipedia:Intermediate_phalanges" ; oboInOwl:hasExactSynonym "intermediate phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial phalanx", "penultimate phalanx", "phalanx 2", "phalanx II" ; oboInOwl:id "UBERON:0004301" ; a owl:Class ; rdfs:label "middle phalanx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004300 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0004302 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003221 [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003221 ] [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003221 ] ) ] . obo:UBERON_0004302 obo:IAO_0000115 "Proximal-most phalanx within a digit." ; obo:UBPROP_0000008 "Proximal phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones at the base of a toe or finger, the prominent, knobby ends of which are often called the knuckles. In other vertebrates, proximal phalanges have a similar placement in the corresponding limbs, be they paw, wing or fin. In many species, they are the longest and thickest phalanx ('finger' bone)" ; obo:UBPROP_0000105 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010680", "EMAPA:35716", "MA:0002916", "SCTID:299708005", "Wikipedia:Proximal_phalanges" ; oboInOwl:hasExactSynonym "phalanx 1", "phalanx I", "proximal-most phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004302" ; a owl:Class ; rdfs:label "proximal phalanx" ; owl:equivalentClass _:genid133483 . obo:UBERON_0004311 obo:IAO_0000115 "A distal phalanx that is part of a hand digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23946", "SCTID:361784003" ; oboInOwl:hasExactSynonym "2nd digit of hand distal phalanx", "2nd finger distal phalanx", "distal phalanx of 2nd digit of hand", "distal phalanx of 2nd finger", "distal phalanx of index finger", "distal phalanx of manual digit II", "distal phalanx of second digit of hand", "distal phalanx of second finger", "hand digit 2 distal phalanx", "second distal phalanx of hand", "second finger distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004311" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of manual digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0004312 obo:IAO_0000115 "A distal phalanx that is part of a hand digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23947", "SCTID:361786001", "SCTID:370674002" ; oboInOwl:hasExactSynonym "3rd digit of hand distal phalanx", "3rd finger distal phalanx", "distal phalanx of 3rd digit of hand", "distal phalanx of 3rd finger", "distal phalanx of manual digit III", "distal phalanx of middle finger", "distal phalanx of third digit of hand", "distal phalanx of third finger", "equine 3rd phalanx of forelimb digit 3", "equine forelimb distal phalanx", "hand digit 3 distal phalanx", "third distal phalanx of hand", "third finger distal phalanx" ; oboInOwl:hasNarrowSynonym "forelimb coffin bone", "forelimb medial claw of artiodactyl", "forelimb medial claw of ruminant hoof", "forelimb medial ungual phalanx of artiodactyl", "forelimb pedal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004312" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of manual digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0004313 obo:IAO_0000115 "A distal phalanx that is part of a hand digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23948", "SCTID:361788000" ; oboInOwl:hasExactSynonym "4th digit of hand distal phalanx", "4th finger distal phalanx", "distal phalanx of 4th digit of hand", "distal phalanx of 4th finger", "distal phalanx of fourth digit of hand", "distal phalanx of fourth finger", "distal phalanx of manual digit IV", "distal phalanx of ring finger", "fourth distal phalanx of hand", "fourth finger distal phalanx", "hand digit 4 distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004313" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of manual digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103624 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0004314 obo:IAO_0000115 "A distal phalanx that is part of a hand digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23949", "SCTID:361790004" ; oboInOwl:hasExactSynonym "5th digit of hand distal phalanx", "5th finger distal phalanx", "distal phalanx of 5th digit of hand", "distal phalanx of 5th finger", "distal phalanx of fifth digit of hand", "distal phalanx of fifth finger", "distal phalanx of little finger", "distal phalanx of manual digit V", "fifth distal phalanx of hand", "fifth finger distal phalanx", "hand digit 5 distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004314" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of manual digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0004315 obo:IAO_0000115 "A distal phalanx that is part of a foot digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32627", "SCTID:361799003" ; oboInOwl:hasExactSynonym "distal phalanx of big toe", "distal phalanx of first digit of foot", "distal phalanx of foot digit 1", "distal phalanx of great toe", "distal phalanx of hallux", "distal phalanx of pedal digit I", "first distal phalanx of foot", "foot digit 1 distal phalanx", "hallux distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004315" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of pedal digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0004316 obo:IAO_0000115 "A distal phalanx that is part of a foot digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32628", "SCTID:361801000" ; oboInOwl:hasExactSynonym "2nd toe distal phalanx", "distal phalanx of 2nd toe", "distal phalanx of foot digit 2", "distal phalanx of pedal digit II", "distal phalanx of second digit of foot", "distal phalanx of second toe", "distal phalanx of the 2nd toe", "foot digit 2 distal phalanx", "second distal phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004316" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of pedal digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0004317 obo:IAO_0000115 "A distal phalanx that is part of a foot digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32629", "SCTID:361803002", "SCTID:370673008" ; oboInOwl:hasExactSynonym "3rd toe distal phalanx", "distal phalanx of 3rd toe", "distal phalanx of foot digit 3", "distal phalanx of pedal digit III", "distal phalanx of the 3rd toe", "distal phalanx of third digit of foot", "distal phalanx of third toe", "equine 3rd phalanx of hindlimb digit 3", "equine hindlimb distal phalanx", "foot digit 3 distal phalanx", "third distal phalanx of foot" ; oboInOwl:hasNarrowSynonym "hindlimb coffin bone", "hindlimb medial claw of artiodactyl", "hindlimb medial claw of ruminant hoof", "hindlimb medial ungual phalanx of artiodactyl", "hindlimb pedal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004317" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of pedal digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0004318 obo:IAO_0000115 "A distal phalanx that is part of a foot digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32630", "SCTID:361805009" ; oboInOwl:hasExactSynonym "4th toe distal phalanx", "distal phalanx of 4th toe", "distal phalanx of foot digit 4", "distal phalanx of fourth digit of foot", "distal phalanx of fourth toe", "distal phalanx of pedal digit IV", "distal phalanx of the 4th toe", "foot digit 4 distal phalanx", "fourth distal phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004318" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of pedal digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ] ; owl:equivalentClass _:genid133617 . obo:UBERON_0004319 obo:IAO_0000115 "A distal phalanx that is part of a foot digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32631", "SCTID:10770001", "SCTID:244674003" ; oboInOwl:hasExactSynonym "5th toe distal phalanx", "distal phalanx of 5th toe", "distal phalanx of fifth digit of foot", "distal phalanx of fifth toe", "distal phalanx of foot digit 5", "distal phalanx of little toe", "distal phalanx of pedal digit V", "distal phalanx of the 5th toe", "fifth distal phalanx of foot", "foot digit 5 distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004319" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of pedal digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0004320 obo:IAO_0000115 "A middle phalanx that is part of a hand digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23933", "SCTID:263407002" ; oboInOwl:hasExactSynonym "2nd digit of hand intermediate phalanx", "2nd digit of hand middle phalanx", "2nd finger intermediate phalanx", "2nd finger middle phalanx", "hand digit 2 intermediate phalanx", "hand digit 2 middle phalanx", "intermediate phalanx of 2nd digit of hand", "intermediate phalanx of 2nd finger", "intermediate phalanx of hand digit 2", "intermediate phalanx of second finger", "middle phalanx of 2nd digit of hand", "middle phalanx of 2nd finger", "middle phalanx of index finger", "middle phalanx of manual digit II", "middle phalanx of second digit of hand", "middle phalanx of second finger", "second finger intermediate phalanx", "second finger middle phalanx", "second middle phalanx of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004320" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of manual digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0004321 obo:IAO_0000115 "A middle phalanx that is part of a hand digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23934", "SCTID:263408007", "SCTID:370729003" ; oboInOwl:hasExactSynonym "3rd digit of hand intermediate phalanx", "3rd digit of hand middle phalanx", "3rd finger intermediate phalanx", "3rd finger middle phalanx", "forelimb digit III P2", "hand digit 3 intermediate phalanx", "hand digit 3 middle phalanx", "intermediate phalanx of 3rd digit of hand", "intermediate phalanx of 3rd finger", "intermediate phalanx of hand digit 3", "intermediate phalanx of third finger", "middle phalanx of 3rd digit of hand", "middle phalanx of 3rd finger", "middle phalanx of manual digit III", "middle phalanx of middle finger", "middle phalanx of third digit of hand", "middle phalanx of third finger", "third finger intermediate phalanx", "third finger middle phalanx", "third middle phalanx of hand" ; oboInOwl:hasNarrowSynonym "forelimb short pastern bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004321" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of manual digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0004322 obo:IAO_0000115 "A middle phalanx that is part of a hand digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23935", "SCTID:263409004" ; oboInOwl:hasExactSynonym "4th digit of hand intermediate phalanx", "4th digit of hand middle phalanx", "4th finger intermediate phalanx", "4th finger middle phalanx", "fourth finger intermediate phalanx", "fourth finger middle phalanx", "fourth middle phalanx of hand", "hand digit 4 intermediate phalanx", "hand digit 4 middle phalanx", "intermediate phalanx of 4th digit of hand", "intermediate phalanx of 4th finger", "intermediate phalanx of fourth finger", "intermediate phalanx of hand digit 4", "middle phalanx of 4th digit of hand", "middle phalanx of 4th finger", "middle phalanx of fourth digit of hand", "middle phalanx of fourth finger", "middle phalanx of manual digit IV", "middle phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004322" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of manual digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103624 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0004323 obo:IAO_0000115 "A middle phalanx that is part of a hand digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23936", "SCTID:263410009" ; oboInOwl:hasExactSynonym "5th digit of hand intermediate phalanx", "5th digit of hand middle phalanx", "5th finger intermediate phalanx", "5th finger middle phalanx", "fifth finger intermediate phalanx", "fifth finger middle phalanx", "fifth middle phalanx of hand", "hand digit 5 intermediate phalanx", "hand digit 5 middle phalanx", "intermediate phalanx of 5th digit of hand", "intermediate phalanx of 5th finger", "intermediate phalanx of fifth finger", "intermediate phalanx of hand digit 5", "middle phalanx of 5th digit of hand", "middle phalanx of 5th finger", "middle phalanx of fifth digit of hand", "middle phalanx of fifth finger", "middle phalanx of little finger", "middle phalanx of manual digit V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004323" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of manual digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0004324 obo:IAO_0000115 "A middle phalanx that is part of a foot digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32623", "SCTID:182152006" ; oboInOwl:hasExactSynonym "2nd toe intermediate phalanx", "2nd toe middle phalanx", "foot digit 2 intermediate phalanx", "foot digit 2 middle phalanx", "intermediate phalanx of 2nd toe", "intermediate phalanx of foot digit 2", "middle phalanx of 2nd toe", "middle phalanx of foot digit 2", "middle phalanx of pedal digit II", "middle phalanx of second digit of foot", "middle phalanx of second toe", "middle phalanx of the 2nd toe", "second middle phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004324" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of pedal digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0004325 obo:IAO_0000115 "A middle phalanx that is part of a foot digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32624", "SCTID:182154007", "SCTID:370677009" ; oboInOwl:hasExactSynonym "3rd toe intermediate phalanx", "3rd toe middle phalanx", "foot digit 3 intermediate phalanx", "foot digit 3 middle phalanx", "hindlimb digit III P2", "intermediate phalanx of 3rd toe", "intermediate phalanx of foot digit 3", "middle phalanx of 3rd toe", "middle phalanx of foot digit 3", "middle phalanx of pedal digit III", "middle phalanx of the 3rd toe", "middle phalanx of third digit of foot", "middle phalanx of third toe", "third middle phalanx of foot" ; oboInOwl:hasNarrowSynonym "hindlimb short pastern bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004325" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of pedal digit 3" ; rdfs:subClassOf _:genid133773 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0004326 obo:IAO_0000115 "A middle phalanx that is part of a pedal digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32625", "SCTID:182156009" ; oboInOwl:hasExactSynonym "4th toe intermediate phalanx", "4th toe middle phalanx", "foot digit 4 intermediate phalanx", "foot digit 4 middle phalanx", "fourth middle phalanx of foot", "intermediate phalanx of 4th toe", "intermediate phalanx of foot digit 4", "middle phalanx of 4th toe", "middle phalanx of foot digit 4", "middle phalanx of fourth digit of foot", "middle phalanx of fourth toe", "middle phalanx of pedal digit IV", "middle phalanx of the 4th toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004326" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of pedal digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0004327 obo:IAO_0000115 "A middle phalanx that is part of a pedal digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:230984", "SCTID:182158005", "SCTID:244673009" ; oboInOwl:hasExactSynonym "5th toe intermediate phalanx", "5th toe middle phalanx", "foot digit 5 intermediate phalanx", "foot digit 5 middle phalanx", "intermediate phalanx of 5th toe", "intermediate phalanx of foot digit 5", "middle phalanx of 5th toe", "middle phalanx of foot digit 5", "middle phalanx of little toe", "middle phalanx of pedal digit V", "middle phalanx of the 5th toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004327" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "middle phalanx of pedal digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0004328 obo:IAO_0000115 "A proximal phalanx that is part of a hand digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23919", "SCTID:263403003" ; oboInOwl:hasExactSynonym "2nd digit of hand proximal phalanx", "2nd finger proximal phalanx", "hand digit 2 proximal phalanx", "manual digit 2 proximal phalanx", "manual phalanx II-1", "proximal phalanx of 2nd digit of hand", "proximal phalanx of 2nd finger", "proximal phalanx of index finger", "proximal phalanx of manual digit II", "proximal phalanx of second digit of hand", "proximal phalanx of second finger", "second finger proximal phalanx", "second proximal phalanx of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004328" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manual digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003646 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0004329 obo:IAO_0000115 "A proximal phalanx that is part of a hand digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23920", "SCTID:263404009", "SCTID:370735003" ; oboInOwl:hasExactSynonym "3rd digit of hand proximal phalanx", "3rd finger proximal phalanx", "hand digit 3 proximal phalanx", "manual digit 3 proximal phalanx", "manual phalanx III-1", "proximal phalanx of 3rd digit of hand", "proximal phalanx of 3rd finger", "proximal phalanx of manual digit III", "proximal phalanx of middle finger", "proximal phalanx of third digit of hand", "proximal phalanx of third finger", "third finger proximal phalanx", "third proximal phalanx of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004329" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manual digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003647 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0004330 obo:IAO_0000115 "A proximal phalanx that is part of a hand digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23921", "SCTID:263405005" ; oboInOwl:hasExactSynonym "4th digit of hand proximal phalanx", "4th finger proximal phalanx", "fourth finger proximal phalanx", "fourth proximal phalanx of hand", "hand digit 4 proximal phalanx", "manual digit 4 proximal phalanx", "manual phalanx IV-1", "proximal phalanx of 4th digit of hand", "proximal phalanx of 4th finger", "proximal phalanx of fourth digit of hand", "proximal phalanx of fourth finger", "proximal phalanx of manual digit IV", "proximal phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004330" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manual digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103624 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003648 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0004331 obo:IAO_0000115 "A proximal phalanx that is part of a hand digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23922", "SCTID:263406006" ; oboInOwl:hasExactSynonym "5th digit of hand proximal phalanx", "5th finger proximal phalanx", "fifth finger proximal phalanx", "fifth proximal phalanx of hand", "hand digit 5 proximal phalanx", "manual digit 5 proximal phalanx", "manual phalanx V-1", "proximal phalanx of 5th digit of hand", "proximal phalanx of 5th finger", "proximal phalanx of fifth digit of hand", "proximal phalanx of fifth finger", "proximal phalanx of little finger", "proximal phalanx of manual digit V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004331" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manual digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003649 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0004332 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:43252", "SCTID:182150003" ; oboInOwl:hasExactSynonym "foot digit 1 proximal phalanx", "hallux proximal phalanx", "pedal phalanx I-1", "predal digit 1 proximal phalanx", "proximal phalanx of big toe", "proximal phalanx of foot digit 1", "proximal phalanx of great toe", "proximal phalanx of hallux", "proximal phalanx of pedal digit I", "proximal phalanx of the 1st toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004332" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pedal digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103631 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003650 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0004333 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32618", "SCTID:182151004" ; oboInOwl:hasExactSynonym "2nd toe proximal phalanx", "foot digit 2 proximal phalanx", "pedal phalanx II-1", "predal digit 2 proximal phalanx", "proximal phalanx of 2nd toe", "proximal phalanx of foot digit 2", "proximal phalanx of pedal digit II", "proximal phalanx of second digit of foot", "proximal phalanx of second toe", "proximal phalanx of the 2nd toe", "second proximal phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004333" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pedal digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003651 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0004334 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32619", "SCTID:182153001", "SCTID:370734004" ; oboInOwl:hasExactSynonym "3rd toe proximal phalanx", "foot digit 3 proximal phalanx", "pedal phalanx III-1", "predal digit 3 proximal phalanx", "proximal phalanx of 3rd toe", "proximal phalanx of foot digit 3", "proximal phalanx of pedal digit III", "proximal phalanx of the 3rd toe", "proximal phalanx of third digit of foot", "proximal phalanx of third toe", "third proximal phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004334" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pedal digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103633 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003652 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0004335 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32620", "SCTID:182155008" ; oboInOwl:hasExactSynonym "4th toe proximal phalanx", "foot digit 4 proximal phalanx", "fourth proximal phalanx of foot", "pedal phalanx IV-1", "predal digit 4 proximal phalanx", "proximal phalanx of 4th toe", "proximal phalanx of foot digit 4", "proximal phalanx of fourth digit of foot", "proximal phalanx of fourth toe", "proximal phalanx of pedal digit IV", "proximal phalanx of the 4th toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004335" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pedal digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003653 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0004336 obo:IAO_0000115 "A proximal phalanx that is part of a pedal digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32621", "SCTID:182157000", "SCTID:244672004" ; oboInOwl:hasExactSynonym "5th toe proximal phalanx", "fifth proximal phalanx of foot", "foot digit 5 proximal phalanx", "pedal phalanx V-1", "predal digit 5 proximal phalanx", "proximal phalanx of 5th toe", "proximal phalanx of fifth digit of foot", "proximal phalanx of fifth toe", "proximal phalanx of foot digit 5", "proximal phalanx of little toe", "proximal phalanx of pedal digit V", "proximal phalanx of the 5th toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004336" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of pedal digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003654 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0004337 obo:IAO_0000115 "A distal phalanx that is part of a hand digit 1 [Automatically generated definition]." ; obo:UBPROP_0000008 "The human pollical distal phalanx (PDP) has a pronounced insertion for the flexor pollicis longus (asymmetric towards the radial side), an ungual fossa, and a pair of dissymmetric ungual spines (the ulnar being more prominent). This asymmetry is necessary to ensure that the thumb pulp is always facing the pulps of the other digits, an osteological configuration which provides the maximum contact surface with held objects." ; oboInOwl:hasDbXref "FMA:23945", "SCTID:182007006" ; oboInOwl:hasExactSynonym "PDP", "distal phalanx of first digit of hand", "distal phalanx of manual digit I", "distal phalanx of thumb", "first distal phalanx of hand", "manual digit 1 distal phalanx", "pollical distal phalanx", "thumb distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004337" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal phalanx of manual digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0004338 obo:IAO_0000115 "A proximal phalanx that is part of a hand digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:23918", "SCTID:181992006" ; oboInOwl:hasExactSynonym "first proximal phalanx of hand", "manual digit 1 proximal phalanx", "manual phalanx I-1", "proximal phalanx of first digit of hand", "proximal phalanx of manual digit I", "proximal phalanx of thumb", "thumb proximal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004338" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal phalanx of manual digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101463 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003645 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0004339 obo:IAO_0000115 "Upper part of skull, consisting of parietals, frontals, post-parietals, and in some species the squamosal and a portion of the alisphenoid." ; obo:IAO_0000116 "We follow http://www.ncbi.nlm.nih.gov/pubmed/11523816 (Morriss-Kay) in definingenumerating the components of the skull vault. Note that there is a conflict with Kardong; e.g. in fig 7.10, Kardong places the squamosal in the temporal series. We cannot place the vault as entirely part of the dermatocranium as it has a small splanchnocranium contribution and a sclerotomal contribution" ; obo:UBPROP_0000003 "The earliest tetrapods arose from rhipidistian ancestors and retained many of their skull features, including most of the bones of the dermatocranium.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0002167", "EHDAA:9538", "EMAPA:18016", "FMA:52800", "NCIT:C81188", "SCTID:140592008", "UMLS:C0205950", "VHOG:0000331", "Wikipedia:Calvaria_(skull)", "ZFA:0005606" ; oboInOwl:hasExactSynonym "calva", "cranial vault", "skull vault" ; oboInOwl:hasNarrowSynonym "skull roof" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calvaria", "calvarium", "skullcap" ; oboInOwl:id "UBERON:0004339" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Terminology notes. we include calvarium as a synonym, but Gray's Anatomy's list includes the Ethmoid and Sphenoid bone in the Calvaria. Some books (and HPO) state that calvaria consists of just the frontal bone, parietal bone, temporal bone, and occipital bone. Note vault may not be precisely equivalent to calvaria" ; rdfs:label "vault of skull" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003128 ], _:genid135220 . obo:UBERON_0004340 obo:IAO_0000115 "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG]." ; obo:UBPROP_0000001 "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals. [TFD][VHOG]" ; obo:UBPROP_0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" ; obo:UBPROP_0000007 "allantoic" ; obo:UBPROP_0000011 "a diverticulum of the hindgut endoderm [ISBN:0073040584 (Vertebrates, Kardong)]" ; obo:UBPROP_0000012 "part_of embryo in EHDAA2 - note differences in humans" ; oboInOwl:hasDbXref "BTO:0000474", "EHDAA2:0001504", "EMAPA:16107", "EMAPA_RETIRED:16084", "MESH:D000482", "NCIT:C34101", "RETIRED_EHDAA2:0000114", "SCTID:308825007", "UMLS:C0002084", "VHOG:0000738", "Wikipedia:Allantois" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "allantoic bud" ; oboInOwl:id "UBERON:0004340" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "allantois" ; rdfs:subClassOf obo:UBERON_0005631, _:genid135230, _:genid135232, _:genid135234, _:genid135236 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray25.png"^^xsd:anyURI . obo:UBERON_0004341 obo:IAO_0000115 "The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP]." ; obo:UBPROP_0000003 "(...) the blastopore equivalent of chordates (germ ring in fish, marginal zone/blastopore lip in frog and node/primitive streak in chick and mouse) (...) (reference 1); Indeed, the primitive streak has been considered the homologue of the blastopore since the 1870s (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "VHOG includes a very broad grouping here based on http://www.ncbi.nlm.nih.gov/pubmed/9609826" ; oboInOwl:hasDbXref "EHDAA2:0001525", "EHDAA:185", "EMAPA:16072", "FMA:293110", "MESH:D054240", "NCIT:C28402", "SCTID:361438007", "UMLS:C0033153", "VHOG:0001202", "Wikipedia:Primitive_streak" ; oboInOwl:hasExactSynonym "primitive streak - blastopore - germ ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004341" ; oboInOwl:inSubset core:early_development, core:pheno_slim ; a owl:Class ; rdfs:label "primitive streak" ; rdfs:subClassOf obo:UBERON_0000485, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000926 ], _:genid135245 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Gray13.png"^^xsd:anyURI . obo:UBERON_0004344 obo:IAO_0000115 "Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column." ; obo:IAO_0000232 "current we conflate the cardinal vein and cardinal vein system" ; obo:UBPROP_0000003 "In primitive vertebrates, the basic early embryonic pattern is retained, and blood from anterior and posterior systemic tissues is returned in anterior and posterior cardinal veins, both pairs of veins uniting in common cardinal veins near the heart. In derived vertebrates, the cardinals appear but usually persist only in the embryo, being functionally replaced by alternative adult vessels, the precava and postcava (anterior and posterior venae cavae).[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011022", "BTO:0004385", "EHDAA2:0000213", "EHDAA:1310", "EMAPA:16354", "NCIT:C34116", "SCTID:362860004", "UMLS:C0231085", "VHOG:0001197", "XAO:0000052" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Cuvierian vein", "cardinal sinus", "cardinal vein system" ; oboInOwl:id "UBERON:0004344" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cardinal vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] . obo:UBERON_0004345 obo:IAO_0000115 "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." ; obo:IAO_0000116 "distinction between trophectoderm and trophoblast unclear/inconsistent in many sources" ; obo:UBPROP_0000001 "The outer cellular layer of the mammalian blastocyst. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.750, see_Kardong_KV][VHOG]" ; obo:UBPROP_0000003 "(...) the trophoblast develops rapidly so that contact may be made with the maternal uterine tissues when conditions are appropriate. We have here an excellent example of an embryonic adaptation, the development of a structure never present in either adult or embryo of 'lower' vertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "trophectodermal" ; obo:UBPROP_0000012 "BTO has this has part of the trophoblast" ; oboInOwl:hasDbXref "BTO:0001840", "EHDAA2:0002091", "EHDAA:56", "EMAPA:16046", "VHOG:0000979" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004345" ; oboInOwl:inSubset core:early_development, core:pheno_slim ; a owl:Class ; rdfs:label "trophectoderm" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000274 ], _:genid135262, _:genid135265 . obo:UBERON_0004346 obo:IAO_0000115 "Embryonic structures which begin as undifferentiated mesenchyme attaching to the caudal end of the gonads. The gubernaculum is present only during the development of the urinary and reproductive organs, being replaced by distinct vestiges in males and females[WP]. Enitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus[MP]." ; obo:UBPROP_0000007 "gubernacular" ; obo:UBPROP_0000012 "WP def is male/female, split term? EMAP is male-specific. vestigial adult in FMA. TODO" ; oboInOwl:hasAlternativeId "UBERON:0000452" ; oboInOwl:hasDbXref "NCIT:C82952", "UMLS:C0228051", "Wikipedia:Gubernaculum" ; oboInOwl:hasExactSynonym "gubernaculum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Gabernaculum", "caudal suspensory ligament", "gubernaculae" ; oboInOwl:id "UBERON:0004346" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gubernaculum (male or female)" ; rdfs:subClassOf obo:UBERON_0008845, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000991 ], _:genid135272, _:genid135276 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1138.png"^^xsd:anyURI . obo:UBERON_0004347 obo:IAO_0000115 "An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." ; obo:UBPROP_0000001 "Early outgrowth of presumptive limb.[AAO]" ; oboInOwl:hasDbXref "AAO:0010375", "BTO:0001640", "EMAPA:35944", "FMA:296780", "GAID:1307", "MESH:D018878", "NCIT:C34203", "UMLS:C0282505", "Wikipedia:Limb_bud", "XAO:0003161" ; oboInOwl:hasExactSynonym "limb buds", "limbbud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gemmae membrorum" ; oboInOwl:id "UBERON:0004347" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "developmentally_induced_by Fgf10, capable of initiating limb forming interactions between endoderm and mesoderm" ; rdfs:label "limb bud" ; rdfs:subClassOf obo:UBERON_0004357, [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005733 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002101 ], _:genid135287 . obo:UBERON_0004348 obo:IAO_0000115 "The embryonic structure that gives rise to the corneal ectoderm." ; oboInOwl:hasDbXref "EHDAA:938", "EMAPA:16322", "RETIRED_EHDAA2:0001308", "VHOG:0001296" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004348" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "optic eminence" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000964 ] . obo:UBERON_0004353 obo:IAO_0000115 "An inguinal canal that is part of a female organism. Conveys the round ligament + the ilioinguinal nerve.[WP,unvetted]." ; obo:UBPROP_0000012 "in MP, this is implicitly part of female reproductive system, but not female genitalia" ; oboInOwl:hasDbXref "EMAPA:19171", "MA:0003249", "Wikipedia:Inguinal_canal#Contents" ; oboInOwl:hasExactSynonym "inguinal canal of female" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004353" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "female inguinal canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0006589 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003702 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0004354 obo:IAO_0000115 "An inguinal canal that is part of a male organism. Conveys the spermatic cord and its coverings + the ilioinguinal nerve.[WP,unvetted]." ; obo:UBPROP_0000012 "in MP, this is implicitly part of male reproductive system, but not male genitalia" ; oboInOwl:hasDbXref "EMAPA:26913", "MA:0003256", "Wikipedia:Inguinal_canal#Contents" ; oboInOwl:hasExactSynonym "inguinal canal of male" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004354" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "male inguinal canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000079 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0005352 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003702 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0004356 obo:IAO_0000115 "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." ; obo:IAO_0000232 "note that media, dorsal fins etc have AERs." ; obo:UBPROP_0000001 "Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO]", "Proliferative region that is part of the developing fin fold or fin.[TAO]" ; obo:UBPROP_0000002 "relationship loss: subclass proliferative region (TAO:0000098)[TAO]" ; obo:UBPROP_0000008 "The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold" ; obo:UBPROP_0000009 "maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop" ; oboInOwl:hasDbXref "AAO:0010760", "EMAPA:32744", "NCIT:C34109", "TAO:0002146", "UMLS:C1516037", "Wikipedia:Apical_ectodermal_ridge", "XAO:0004121", "ZFA:0001702" ; oboInOwl:hasExactSynonym "apical epidermal ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "AER", "crista ectodermalis apicalis" ; oboInOwl:id "UBERON:0004356" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "apical ectodermal ridge" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004357 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0010464 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0061037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0003104 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:PR_000007499 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg"^^xsd:anyURI . obo:UBERON_0004357 obo:IAO_0000115 "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." ; obo:UBPROP_0000003 "The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG]" ; oboInOwl:hasDbXref "VHOG:0001258" ; oboInOwl:hasExactSynonym "limb - fin bud", "paired appendage bud", "paired limb/fin bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004357" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:comment "Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]" ; rdfs:label "paired limb/fin bud" ; rdfs:subClassOf obo:UBERON_0003102, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004356 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005732 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0004708 ] . obo:UBERON_0004362 obo:IAO_0000115 "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." ; obo:UBPROP_0000001 "The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]", "the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000103 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "AAO:0010364", "CALOHA:TS-2089", "EHDAA2:0000006", "EHDAA:573", "EMAPA:16118", "FMA:293019", "MFMO:0000095", "NCIT:C34175", "SCTID:308767008", "TAO:0001595", "UMLS:C1517197", "VHOG:0000296", "Wikipedia:First_pharyngeal_arch", "XAO:0000097", "ZFA:0001612" ; oboInOwl:hasExactSynonym "1st pharyngeal arch", "branchial arch 1", "first branchial arch", "first pharyngeal arch", "first visceral arch", "mandibular arch", "visceral arch 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "1st arch", "1st visceral arch", "arcus pharyngeus primus" ; oboInOwl:id "UBERON:0004362" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch 1" ; rdfs:subClassOf obo:UBERON_0002539 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png"^^xsd:anyURI . obo:UBERON_0004363 obo:IAO_0000115 "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." ; obo:IAO_0000116 "add specific artery derivatives" ; obo:IAO_0000232 "Do not confuse with arch of aorta." ; obo:UBPROP_0000001 "Paired vessels arching from the ventral to the dorsal aorta through the pharyngeal arches. [TFD][VHOG]" ; obo:UBPROP_0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" ; obo:UBPROP_0000008 "Number varies - Lampreys have 8, hagfishes 15; only up to 6 appear in embryonic development in most gnathostome fishes and all tetrapods" ; obo:UBPROP_0000011 "The third, fourth, and sixth arches, along with the seventh intersegmental arteries and the left dorsal aorta, are the primary contributors to the normal aortic arch and its major thoracic branches" ; oboInOwl:hasAlternativeId "UBERON:0004342" ; oboInOwl:hasDbXref "AAO:0010414", "EFO:0003695", "EHDAA2:0000186", "EHDAA:398", "EHDAA:7327", "EMAPA:16684", "NCIT:C32123", "TAO:0005004", "UMLS:C0003489", "VHOG:0000122", "Wikipedia:Aortic_arches", "XAO:0000341", "ZFA:0005004" ; oboInOwl:hasExactSynonym "PAA", "aortic arch", "aortic arches", "branchial aortic arches", "branchial arch artery", "embryonic aortic arch artery", "pharyngeal arch artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "a. arcuum pharyngeorum", "aortic arch artery", "arteriae arcuum pharyngeorum", "branchial aortic arches", "pharyngeal arch arteries", "pharyngeal arch artery" ; oboInOwl:id "UBERON:0004363" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal arch artery" ; rdfs:subClassOf obo:UBERON_0001637, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002539 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001637 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002539 ], _:genid135352, _:genid135354 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png"^^xsd:anyURI . obo:UBERON_0004365 obo:IAO_0000115 "Blood vessel that is connected to the yolk sac." ; oboInOwl:hasDbXref "EMAPA:36494" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004365" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vitelline blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004374 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] . obo:UBERON_0004367 obo:IAO_0000115 "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]." ; obo:UBPROP_0000001 "Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN]" ; oboInOwl:hasDbXref "EMAPA:18804", "FMA:58309", "GAID:894", "MA:0001246", "MESH:D003886", "NCIT:C32454", "SCTID:281076002", "TAO:0002157", "UMLS:C0011665", "Wikipedia:Descemet%27s_membrane", "ZFA:0001686" ; oboInOwl:hasExactSynonym "Descemet membrane", "Descemet's posterior elastic lamina", "lamina limitans posterior", "lamina limitans posterior corneae", "posterior limiting lamina", "posterior limiting lamina of cornea", "posterior limiting membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004367" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed)" ; rdfs:label "Descemet's membrane" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/15"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000964 ], _:genid135390 ; owl:disjointWith obo:UBERON_0004370 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001985 ] ) ] . obo:UBERON_0004368 obo:IAO_0000115 "A continuous cartilaginous formation in mesenchyme of the second pharyngeal arch in the embryo. The longer cranial or styloid segment is continuous with the otic capsule; its inferior end is angulated and is situated very close to the oropharynx. The smaller caudal segment is in contact with the body and greater horn of the hyoid cartilaginous structure." ; obo:UBPROP_0000011 "Classically defined as: a structure... develop the stapes, the styloid processes, the stylohyoid ligaments, and the lesser cornua of the hyoid bone; its proximal end gives rise to the stylohyoid ligament. Relationship to stapes disputed." ; obo:UBPROP_0000012 "in EHDAA2 this also develops from 3rd arch Mes from NC" ; oboInOwl:hasDbXref "EHDAA2:0000793", "EMAPA:17622", "FMA:295800" ; oboInOwl:hasExactSynonym "Reichert cartilage", "hyaloid cartilage", "hyoid cartilage", "second branchial arch cartilage", "second pharyngeal arch cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004368" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "Reichert's cartilage" ; rdfs:subClassOf obo:UBERON_0007844, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003066 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010354 ], _:genid135402 . obo:UBERON_0004370 obo:IAO_0000115 "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." ; obo:UBPROP_0000001 "Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO]" ; obo:UBPROP_0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" ; oboInOwl:hasDbXref "FMA:58273", "MA:0001240", "NCIT:C32226", "SCTID:281075003", "TAO:0002155", "UMLS:C0229127", "Wikipedia:Bowman%27s_membrane", "ZFA:0001684" ; oboInOwl:hasExactSynonym "Bowman's anterior elastic lamina", "Bowman's layer", "Bowman's membrane", "anterior elastic lamina", "anterior limiting lamina", "anterior limiting lamina of cornea", "lamina limitans anterior (cornea)", "lamina limitans anterior corneae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Reichert's membrane", "anterior limiting membrane" ; oboInOwl:id "UBERON:0004370" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "anterior limiting lamina of cornea" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001772 ] ) ] . obo:UBERON_0004374 obo:IAO_0000115 "Vascular network that is connected to the yolk sac." ; oboInOwl:hasDbXref "Wikipedia:Vitelline_circulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "omphalomesenteric system", "vitelline bloos vessel system", "vitelline system" ; oboInOwl:id "UBERON:0004374" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vitelline vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] . obo:UBERON_0004375 obo:IAO_0000115 "A bone that is part of an appendage [Automatically generated definition]." ; oboInOwl:hasExactSynonym "appendage bone", "bone of appendage", "bone of free segment of appendicular skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004375" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "bone of free limb or fin" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011582 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004708 ] ) ] . obo:UBERON_0004377 obo:IAO_0000115 "A metaphysis that is in the distal side of a diaphysis." ; oboInOwl:hasDbXref "FMA:32824" ; oboInOwl:hasExactSynonym "distal diaphyseal end of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004377" ; a owl:Class ; rdfs:label "distal metaphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000125 ; owl:someValuesFrom obo:UBERON_0004769 ] ) ] . obo:UBERON_0004378 obo:IAO_0000115 "A metaphysis that is in the proximal side of a diaphysis." ; oboInOwl:hasDbXref "FMA:32823" ; oboInOwl:hasExactSynonym "proximal diaphyseal end of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004378" ; a owl:Class ; rdfs:label "proximal metaphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000124 ; owl:someValuesFrom obo:UBERON_0004769 ] ) ] . obo:UBERON_0004379 obo:IAO_0000115 "An epiphysis that is on the distal side of the bone." ; oboInOwl:hasDbXref "FMA:32822", "SCTID:279999006" ; oboInOwl:hasExactSynonym "distal end of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004379" ; a owl:Class ; rdfs:label "distal epiphysis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004377 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000125 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_0004380 obo:IAO_0000115 "An epiphysis that is on the proximal side of the bone." ; oboInOwl:hasDbXref "FMA:32821", "SCTID:279998003" ; oboInOwl:hasExactSynonym "proximal end of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004380" ; a owl:Class ; rdfs:label "proximal epiphysis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004378 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000124 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_0004381 obo:IAO_0000115 "The collection of all skeletal elements in an individual limb." ; obo:UBPROP_0000001 "Skeletal subdivision that is part of the limb.[VSAO]" ; obo:UBPROP_0000012 "EHDAA2 considers hip and shoulder joints part of limb skeleton." ; oboInOwl:hasDbXref "EHDAA2:0002221", "EMAPA:32702", "VSAO:0000300" ; oboInOwl:hasExactSynonym "free limb skeleton", "limb skeleton", "set of bones of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004381" ; a owl:Class ; rdfs:label "skeleton of limb" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0004382 obo:IAO_0000115 "An epiphysis that is part of a humerus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32825", "SCTID:313054009" ; oboInOwl:hasExactSynonym "humeral epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004382" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_0004383 obo:IAO_0000115 "An epiphysis that is part of a tibia [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37771", "FMA:33112", "MA:0003113", "SCTID:314626006" ; oboInOwl:hasExactSynonym "tibial epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004383" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0004384 obo:IAO_0000115 "An epiphysis that is part of a femur [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37539", "FMA:32838", "MA:0003056", "SCTID:314625005" ; oboInOwl:hasExactSynonym "femoral epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004384" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:UBERON_0004385 obo:IAO_0000115 "An epiphysis that is part of a radius [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33770", "SCTID:313055005" ; oboInOwl:hasExactSynonym "radial epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004385" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0004386 obo:IAO_0000115 "An epiphysis that is part of an ulna [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33748", "SCTID:313056006" ; oboInOwl:hasExactSynonym "ulnar epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004386" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of ulna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0004387 obo:IAO_0000115 "An epiphysis that is part of a phalanx of a manus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:240707", "SCTID:314620000" ; oboInOwl:hasExactSynonym "epiphysis of phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epiphysis of phalanx of hand" ; oboInOwl:id "UBERON:0004387" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of phalanx of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] . obo:UBERON_0004388 obo:IAO_0000115 "An epiphysis that is part of a fibula [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33726" ; oboInOwl:hasExactSynonym "fibula epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004388" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0004389 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33814", "SCTID:313057002" ; oboInOwl:hasExactSynonym "epiphysis of metatarsal", "metatarsal bone epiphysis", "metatarsal epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004389" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of metatarsal bone" ; owl:equivalentClass _:genid134310 . obo:UBERON_0004390 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33792", "SCTID:314907001" ; oboInOwl:hasExactSynonym "epiphysis of metacarpal", "metacarpal bone epiphysis", "metacarpal epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004390" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] . obo:UBERON_0004391 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33793" ; oboInOwl:hasExactSynonym "first metacarpal bone epiphysis", "metacarpal 1 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004391" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of first metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] . obo:UBERON_0004392 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33794" ; oboInOwl:hasExactSynonym "metacarpal 2 epiphysis", "second metacarpal bone epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004392" ; a owl:Class ; rdfs:label "epiphysis of second metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003646 ] ) ] . obo:UBERON_0004393 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86328" ; oboInOwl:hasExactSynonym "metacarpal 3 epiphysis", "third metacarpal bone epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004393" ; a owl:Class ; rdfs:label "epiphysis of third metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003647 ] ) ] . obo:UBERON_0004394 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86329" ; oboInOwl:hasExactSynonym "fourth metacarpal bone epiphysis", "metacarpal 4 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004394" ; a owl:Class ; rdfs:label "epiphysis of fourth metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 _:genid134342 ) ] . obo:UBERON_0004395 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33815" ; oboInOwl:hasExactSynonym "first metatarsal bone epiphysis", "metatarsal 1 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004395" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of first metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003650 ] ) ] . obo:UBERON_0004396 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33816" ; oboInOwl:hasExactSynonym "metatarsal 2 epiphysis", "second metatarsal bone epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004396" ; a owl:Class ; rdfs:label "epiphysis of second metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 _:genid134354 ) ] . obo:UBERON_0004397 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86313" ; oboInOwl:hasExactSynonym "metatarsal 3 epiphysis", "third metatarsal bone epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004397" ; a owl:Class ; rdfs:label "epiphysis of third metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003652 ] ) ] . obo:UBERON_0004398 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86314" ; oboInOwl:hasExactSynonym "fourth metatarsal bone epiphysis", "metatarsal 4 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004398" ; a owl:Class ; rdfs:label "epiphysis of fourth metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003653 ] ) ] . obo:UBERON_0004399 obo:IAO_0000115 "An epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86315" ; oboInOwl:hasExactSynonym "fifth metatarsal bone epiphysis", "metatarsal 5 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004399" ; a owl:Class ; rdfs:label "epiphysis of fifth metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003654 ] ) ] . obo:UBERON_0004400 obo:IAO_0000115 "A portion of bone tissue that is part of a epiphysis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:241364" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004400" ; a owl:Class ; rdfs:label "bone tissue of epiphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001437 ] ) ] . obo:UBERON_0004401 obo:IAO_0000115 "A portion of bone tissue that is part of a distal epiphysis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:241374" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004401" ; a owl:Class ; rdfs:label "bone tissue of distal epiphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004379 ] ) ] . obo:UBERON_0004402 obo:IAO_0000115 "A portion of bone tissue that is part of a proximal epiphysis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:241372" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004402" ; a owl:Class ; rdfs:label "bone tissue of proximal epiphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004380 ] ) ] . obo:UBERON_0004403 obo:IAO_0000115 "A periosteum that is part of a epiphysis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32687" ; oboInOwl:hasExactSynonym "epiphysis periosteum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004403" ; a owl:Class ; rdfs:label "periosteum of epiphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002515 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001437 ] ) ] . obo:UBERON_0004404 obo:IAO_0000115 "A distal epiphysis that is part of a humerus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32826", "SCTID:310655007" ; oboInOwl:hasExactSynonym "distal end of humerus", "lower end of humerus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004404" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_0004405 obo:IAO_0000115 "A distal epiphysis that is part of a tibia [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33116", "SCTID:302527001", "Wikipedia:Lower_extremity_of_tibia" ; oboInOwl:hasExactSynonym "distal end of tibia", "lower end of tibia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004405" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0004406 obo:IAO_0000115 "A distal epiphysis that is part of a femur [Automatically generated definition]." ; obo:UBPROP_0000001 "Head of the femur that articulates with the tibia and fibula.[AAO]" ; oboInOwl:hasDbXref "AAO:0000893", "FMA:32844", "SCTID:280016000" ; oboInOwl:hasExactSynonym "distal femoral epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal head of femur" ; oboInOwl:id "UBERON:0004406" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:UBERON_0004407 obo:IAO_0000115 "A distal epiphysis that is part of a radius [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33776", "SCTID:280013008", "Wikipedia:Lower_extremity_of_radius" ; oboInOwl:hasExactSynonym "distal end of radius", "lower end of radius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004407" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0004408 obo:IAO_0000115 "A distal epiphysis that is part of a ulna [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33754", "SCTID:302521000" ; oboInOwl:hasExactSynonym "distal end of ulna", "lower end of ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004408" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of ulna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0004409 obo:IAO_0000115 "A distal epiphysis that is part of a phalanx of manus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:226577", "SCTID:272707006" ; oboInOwl:hasExactSynonym "distal epiphysis of phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal end of phalanx of hand", "distal epiphysis of phalanx of hand", "head of phalanx of finger", "head of phalanx of hand", "ungual tuberosity of distal phalanx of finger" ; oboInOwl:id "UBERON:0004409" ; a owl:Class ; rdfs:label "distal epiphysis of phalanx of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] . obo:UBERON_0004410 obo:IAO_0000115 "A distal epiphysis that is part of a fibula [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33732", "SCTID:129111008", "SCTID:280018004" ; oboInOwl:hasExactSynonym "distal end of fibula", "lower end of fibula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004410" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0004411 obo:IAO_0000115 "The upper extremity of the humerus (proximal humerus) consists of a large rounded head joined to the body by a constricted portion called the neck, and two eminences, the greater and lesser tubercles." ; oboInOwl:hasDbXref "FMA:23362", "SCTID:280028008", "Wikipedia:Upper_extremity_of_humerus" ; oboInOwl:hasExactSynonym "proximal end of humerus", "proximal humeral epiphysis", "upper end of humerus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "head of the humerus", "humeral head", "proximal humerus", "upper extremity of humerus" ; oboInOwl:id "UBERON:0004411" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray207.png"^^xsd:anyURI . obo:UBERON_0004412 obo:IAO_0000115 "A proximal epiphysis that is part of a femur [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:32841", "SCTID:244702009" ; oboInOwl:hasExactSynonym "proximal femoral epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "capital femoral epiphysis" ; oboInOwl:id "UBERON:0004412" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:UBERON_0004413 obo:IAO_0000115 "A proximal epiphysis that is part of a radius [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:39780", "SCTID:280029000", "Wikipedia:Upper_extremity_of_radius" ; oboInOwl:hasExactSynonym "proximal end of radius", "proximal radial epiphysis", "upper end of radius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004413" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0004414 obo:IAO_0000115 "A proximal epiphysis that is part of a phalanx of manus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:226482", "SCTID:272704004" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of finger", "base of phalanx of finger", "basis phalangis manus", "proximal epiphysis of phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal epiphysis of phalanx of hand" ; oboInOwl:id "UBERON:0004414" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001436 ] ) ] . obo:UBERON_0004415 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33817", "SCTID:119545008" ; oboInOwl:hasExactSynonym "base of metatarsal bone", "basis ossis metatarsi", "proximal end of metatarsal bone", "upper end of metatarsal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004415" ; a owl:Class ; rdfs:label "proximal epiphysis of metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001448 ] ) ] . obo:UBERON_0004416 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:33795", "SCTID:272695001" ; oboInOwl:hasExactSynonym "base of metacarpal bone", "basis ossis metacarpi", "metacarpal bone base", "proximal end of metacarpal bone", "upper end of metacarpal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004416" ; a owl:Class ; rdfs:label "proximal epiphysis of metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] . obo:UBERON_0004417 obo:IAO_0000115 "A proximal epiphysis that is part of a manual digit 1 phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37489", "SCTID:272700008" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of thumb", "base of phalanx of first digit of hand", "base of phalanx of thumb", "proximal epiphysis of phalanx of manual digit 1", "proximal epiphysis of phalanx of manual digit I" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of phalanx of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004417" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manual digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003620 ] ) ] . obo:UBERON_0004418 obo:IAO_0000115 "A proximal epiphysis that is part of a manual digit 2 phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37498", "SCTID:368307004" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of index finger", "base of phalanx of index finger", "base of phalanx of second digit of hand", "base of phalanx of second finger", "proximal epiphysis of phalanx of manual digit 2", "proximal epiphysis of phalanx of manual digit II" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of phalanx of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004418" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003636 ] ) ] . obo:UBERON_0004419 obo:IAO_0000115 "A proximal epiphysis that is part of a manual digit 3 phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37510", "SCTID:181997000" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of middle finger", "base of phalanx of middle finger", "base of phalanx of third digit of hand", "base of phalanx of third finger", "proximal epiphysis of phalanx of manual digit 3", "proximal epiphysis of phalanx of manual digit III" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of phalanx of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004419" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003637 ] ) ] . obo:UBERON_0004420 obo:IAO_0000115 "A proximal epiphysis that is part of a manual digit 4 phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37522", "SCTID:368337008" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of ring finger", "base of phalanx of fourth digit of hand", "base of phalanx of fourth finger", "base of phalanx of ring finger", "proximal epiphysis of phalanx of manual digit 4", "proximal epiphysis of phalanx of manual digit IV" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004420" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003638 ] ) ] . obo:UBERON_0004421 obo:IAO_0000115 "A proximal epiphysis that is part of a manual digit 5 phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37534", "SCTID:368351008" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of fifth finger", "basal epiphysis of phalanx of little finger", "base of phalanx of fifth digit of hand", "base of phalanx of fifth finger", "base of phalanx of little finger", "proximal epiphysis of phalanx of manual digit 5", "proximal epiphysis of phalanx of manual digit V" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of phalanx of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004421" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of manual digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003639 ] ) ] . obo:UBERON_0004422 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42788", "SCTID:181978000" ; oboInOwl:hasExactSynonym "base of first metacarpal bone", "first metacarpal bone base", "proximal epiphysis of metacarpal 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004422" ; a owl:Class ; rdfs:label "proximal epiphysis of first metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] . obo:UBERON_0004423 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42791", "SCTID:263461004" ; oboInOwl:hasExactSynonym "base of second metacarpal bone", "proximal end of second metacarpal bone", "proximal epiphysis of metacarpal 2", "second metacarpal bone base" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004423" ; a owl:Class ; rdfs:label "proximal epiphysis of second metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003646 ] ) ] . obo:UBERON_0004424 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42794", "SCTID:263465008" ; oboInOwl:hasExactSynonym "base of third metacarpal bone", "proximal end of third metacarpal bone", "proximal epiphysis of metacarpal 3", "third metacarpal bone base" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004424" ; a owl:Class ; rdfs:label "proximal epiphysis of third metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003647 ] ) ] . obo:UBERON_0004425 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42797", "SCTID:263469002" ; oboInOwl:hasExactSynonym "base of fourth metacarpal bone", "fourth metacarpal bone base", "proximal end of fourth metacarpal bone", "proximal epiphysis of metacarpal 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004425" ; a owl:Class ; rdfs:label "proximal epiphysis of fourth metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003648 ] ) ] . obo:UBERON_0004426 obo:IAO_0000115 "A proximal epiphysis that is part of a metacarpal bone of digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42800", "SCTID:263473004" ; oboInOwl:hasExactSynonym "base of fifth metacarpal bone", "fifth metacarpal bone base", "proximal end of fifth metacarpal bone", "proximal epiphysis of metacarpal 5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004426" ; a owl:Class ; rdfs:label "proximal epiphysis of fifth metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003649 ] ) ] . obo:UBERON_0004427 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42963", "SCTID:182124002" ; oboInOwl:hasExactSynonym "base of first metatarsal bone", "proximal end of first metatarsal bone", "proximal epiphysis of metatarsal 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004427" ; a owl:Class ; rdfs:label "proximal epiphysis of first metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid134600 ] . obo:UBERON_0004428 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42964", "SCTID:182130002" ; oboInOwl:hasExactSynonym "base of second metatarsal bone", "proximal end of second metatarsal bone", "proximal epiphysis of metatarsal 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004428" ; a owl:Class ; rdfs:label "proximal epiphysis of second metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003651 ] ) ] . obo:UBERON_0004429 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42965", "SCTID:182135007" ; oboInOwl:hasExactSynonym "base of third metatarsal bone", "proximal end of third metatarsal bone", "proximal epiphysis of metatarsal 3" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004429" ; a owl:Class ; rdfs:label "proximal epiphysis of third metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003652 ] ) ] . obo:UBERON_0004430 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42966", "SCTID:182140004" ; oboInOwl:hasExactSynonym "base of fourth metatarsal bone", "proximal end of fourth metatarsal bone", "proximal epiphysis of metatarsal 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004430" ; a owl:Class ; rdfs:label "proximal epiphysis of fourth metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003653 ] ) ] . obo:UBERON_0004431 obo:IAO_0000115 "A proximal epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:42967", "SCTID:182145009" ; oboInOwl:hasExactSynonym "base of fifth metatarsal bone", "proximal end of fifth metatarsal bone", "proximal epiphysis of metatarsal 5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004431" ; a owl:Class ; rdfs:label "proximal epiphysis of fifth metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003654 ] ) ] . obo:UBERON_0004432 obo:IAO_0000115 "A proximal epiphysis that is part of a distal phalanx of manual digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37505", "SCTID:263445001" ; oboInOwl:hasExactSynonym "basal epiphysis of distal phalanx of index finger", "base of distal phalanx of index finger", "base of distal phalanx of second digit of hand", "base of distal phalanx of second finger", "proximal epiphysis of distal phalanx of manual digit II" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of distal phalanx of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004432" ; a owl:Class ; rdfs:label "proximal epiphysis of distal phalanx of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] . obo:UBERON_0004433 obo:IAO_0000115 "A proximal epiphysis that is part of a distal phalanx of manual digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37517", "SCTID:263446000" ; oboInOwl:hasExactSynonym "base of distal phalanx of middle finger", "base of distal phalanx of third digit of hand", "base of distal phalanx of third finger", "proximal epiphysis of distal phalanx of manual digit III" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of distal phalanx of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004433" ; a owl:Class ; rdfs:label "proximal epiphysis of distal phalanx of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] . obo:UBERON_0004434 obo:IAO_0000115 "A proximal epiphysis that is part of a distal phalanx of manual digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37529", "SCTID:263447009" ; oboInOwl:hasExactSynonym "basal epiphysis of distal phalanx of fourth finger", "basal epiphysis of distal phalanx of ring finger", "base of distal phalanx of fourth digit of hand", "base of distal phalanx of fourth finger", "base of distal phalanx of ring finger", "proximal epiphysis of distal phalanx of manual digit IV" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of distal phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004434" ; a owl:Class ; rdfs:label "proximal epiphysis of distal phalanx of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] . obo:UBERON_0004435 obo:IAO_0000115 "A proximal epiphysis that is part of a distal phalanx of manual digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37541", "SCTID:263448004" ; oboInOwl:hasExactSynonym "basal epiphysis of distal phalanx of fifth finger", "basal epiphysis of distal phalanx of little finger", "base of distal phalanx of fifth digit of hand", "base of distal phalanx of fifth finger", "base of distal phalanx of little finger", "proximal epiphysis of distal phalanx of manual digit V" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of distal phalanx of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004435" ; a owl:Class ; rdfs:label "proximal epiphysis of distal phalanx of manual digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] . obo:UBERON_0004436 obo:IAO_0000115 "A proximal epiphysis that is part of a middle phalanx of manual digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37502", "SCTID:263428006" ; oboInOwl:hasExactSynonym "basal epiphysis of middle phalanx of index finger", "base of middle phalanx of index finger", "base of middle phalanx of second digit of hand", "base of middle phalanx of second finger", "proximal epiphysis of middle phalanx of manual digit II" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of middle phalanx of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004436" ; a owl:Class ; rdfs:label "proximal epiphysis of middle phalanx of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004320 ] ) ] . obo:UBERON_0004437 obo:IAO_0000115 "A proximal epiphysis that is part of a middle phalanx of manual digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37514", "SCTID:263429003" ; oboInOwl:hasExactSynonym "basal epiphysis of middle phalanx of middle finger", "base of middle phalanx of middle finger", "base of middle phalanx of third digit of hand", "base of middle phalanx of third finger", "proximal epiphysis of middle phalanx of manual digit III" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of middle phalanx of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004437" ; a owl:Class ; rdfs:label "proximal epiphysis of middle phalanx of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004321 ] ) ] . obo:UBERON_0004438 obo:IAO_0000115 "A proximal epiphysis that is part of a middle phalanx of manual digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37526", "SCTID:263430008" ; oboInOwl:hasExactSynonym "basal epiphysis of middle phalanx of fourth finger", "basal epiphysis of middle phalanx of ring finger", "base of middle phalanx of fourth digit of hand", "base of middle phalanx of fourth finger", "base of middle phalanx of ring finger", "proximal epiphysis of middle phalanx of manual digit IV" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of middle phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004438" ; a owl:Class ; rdfs:label "proximal epiphysis of middle phalanx of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004322 ] ) ] . obo:UBERON_0004439 obo:IAO_0000115 "A proximal epiphysis that is part of a middle phalanx of manual digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37538", "SCTID:263431007" ; oboInOwl:hasExactSynonym "basal epiphysis of middle phalanx of fifth finger", "basal epiphysis of middle phalanx of little finger", "base of middle phalanx of fifth digit of hand", "base of middle phalanx of fifth finger", "base of middle phalanx of little finger", "proximal epiphysis of middle phalanx of manual digit V" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of middle phalanx of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004439" ; a owl:Class ; rdfs:label "proximal epiphysis of middle phalanx of manual digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004323 ] ) ] . obo:UBERON_0004440 obo:IAO_0000115 "A proximal epiphysis that is part of a proximal phalanx of manual digit 2 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37499", "SCTID:263412001" ; oboInOwl:hasExactSynonym "base of proximal phalanx of index finger", "base of proximal phalanx of second digit of hand", "base of proximal phalanx of second finger", "proximal epiphysis of proximal phalanx of manual digit II" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of proximal phalanx of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004440" ; a owl:Class ; rdfs:label "proximal epiphysis of proximal phalanx of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004328 ] ) ] . obo:UBERON_0004441 obo:IAO_0000115 "A proximal epiphysis that is part of a proximal phalanx of manual digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37511", "SCTID:263413006" ; oboInOwl:hasExactSynonym "basal epiphysis of proximal phalanx of middle finger", "base of proximal phalanx of middle finger", "base of proximal phalanx of third digit of hand", "base of proximal phalanx of third finger", "proximal epiphysis of proximal phalanx of manual digit III" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of proximal phalanx of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004441" ; a owl:Class ; rdfs:label "proximal epiphysis of proximal phalanx of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] . obo:UBERON_0004442 obo:IAO_0000115 "A proximal epiphysis that is part of a proximal phalanx of manual digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37523", "SCTID:263414000" ; oboInOwl:hasExactSynonym "basal epiphysis of proximal phalanx of fourth finger", "basal epiphysis of proximal phalanx of ring finger", "base of proximal phalanx of fourth digit of hand", "base of proximal phalanx of fourth finger", "base of proximal phalanx of ring finger", "proximal epiphysis of proximal phalanx of manual digit IV" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of proximal phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004442" ; a owl:Class ; rdfs:label "proximal epiphysis of proximal phalanx of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] . obo:UBERON_0004443 obo:IAO_0000115 "A proximal epiphysis that is part of a proximal phalanx of manual digit 5 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37535", "SCTID:263415004" ; oboInOwl:hasExactSynonym "basal epiphysis of proximal phalanx of little finger", "base of proximal phalanx of fifth digit of hand", "base of proximal phalanx of fifth finger", "base of proximal phalanx of little finger", "proximal epiphysis of proximal phalanx of manual digit V" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of proximal phalanx of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004443" ; a owl:Class ; rdfs:label "proximal epiphysis of proximal phalanx of manual digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] . obo:UBERON_0004444 obo:IAO_0000115 "A proximal epiphysis that is part of a distal phalanx of manual digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37493", "SCTID:182008001" ; oboInOwl:hasExactSynonym "base of distal phalanx of thumb", "proximal epiphysis of distal phalanx of manual digit I" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of distal phalanx of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004444" ; a owl:Class ; rdfs:label "proximal epiphysis of distal phalanx of manual digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] . obo:UBERON_0004445 obo:IAO_0000115 "A proximal epiphysis that is part of a proximal phalanx of manual digit 1 [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:37490", "SCTID:181993001" ; oboInOwl:hasExactSynonym "basal epiphysis of proximal phalanx of thumb", "base of proximal phalanx of thumb", "proximal epiphysis of proximal phalanx of manual digit I" ; oboInOwl:hasNarrowSynonym "proximal epiphysis of proximal phalanx of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004445" ; a owl:Class ; rdfs:label "proximal epiphysis of proximal phalanx of manual digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] . obo:UBERON_0004446 obo:IAO_0000115 "An epiphysis that is part of a phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:280033007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004446" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of phalanx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003221 ] ) ] . obo:UBERON_0004447 obo:IAO_0000115 "A proximal epiphysis that is part of a phalanx [Automatically generated definition]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004447" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003221 ] ) ] . obo:UBERON_0004448 obo:IAO_0000115 "A distal epiphysis that is part of a phalanx [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:110520001" ; oboInOwl:hasExactSynonym "head of phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004448" ; a owl:Class ; rdfs:label "distal epiphysis of phalanx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003221 ] ) ] . obo:UBERON_0004449 obo:IAO_0000115 "One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain." ; obo:UBPROP_0000001 "Part of the internal carotid containing many branches supplying blood to the chorioid plexuses of the brain.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of internal carotid (AAO:0010219)[AAO]" ; obo:UBPROP_0000012 "in AAO this is part_of the internal carotid, but in humans the PCA intervenes for some cerebral arteries. Proper comparative review required" ; oboInOwl:hasDbXref "AAO:0010493", "BTO:0005205", "CALOHA:TS-0126", "EHDAA2:0000233", "EHDAA:5294", "EMAPA:18613", "GAID:484", "MA:0002562", "MESH:D002536", "NCIT:C12691", "SCTID:181308008", "UMLS:C0007770", "Wikipedia:Cerebral_artery", "XAO:0000367" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004449" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebral artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003709 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0004451 obo:IAO_0000115 "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra." ; obo:UBPROP_0000008 "In humans, there are 24 presacral vertebrae (7 cervical, 12 thoracic, and 5 lumbar)" ; obo:UBPROP_0000012 "it's not clear if the XAO class belongs here or below" ; oboInOwl:hasDbXref "EMAPA:37722", "MA:0002869", "XAO:0003077" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presacral vertebra" ; oboInOwl:id "UBERON:0004451" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "trunk or cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002412 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0001095 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002413 obo:UBERON_0011677 ) ] . obo:UBERON_0004452 obo:IAO_0000115 "A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted]." ; oboInOwl:hasAlternativeId "UBERON:0001462" ; oboInOwl:hasDbXref "EHDAA2:0000218", "EHDAA:5196", "EMAPA:19122", "EMAPA:32784", "FMA:24922", "GAID:59", "MA:0000039", "MESH:D014953", "NCIT:C111033", "SCTID:361289009", "Wikipedia:Wrist", "galen:Wrist" ; oboInOwl:hasExactSynonym "carpal limb segment", "carpal segment", "fore basipodium", "fore mesopodium", "hand mesopodium", "manus mesopodium", "regio carpalis", "wrist", "wrist region" ; oboInOwl:hasNarrowSynonym "carpus of fore-paw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio radiocarpea", "carpus" ; oboInOwl:id "UBERON:0004452" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "carpal region" ; rdfs:subClassOf obo:UBERON_0008785, [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0004453 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0002386 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006716 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png"^^xsd:anyURI, "https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg"^^xsd:anyURI . obo:UBERON_0004453 obo:IAO_0000115 "A metapodium region that is part of a manus." ; obo:IAO_0000116 "Note that along with FMA we treat this as a limb segment rather than a purely skeletal element" ; obo:UBPROP_0000007 "metacarpal" ; obo:UBPROP_0000012 "Note that mammalian and non-mammalian AOs differ in whether they consider this a part of the skeleton" ; oboInOwl:hasDbXref "CALOHA:TS-2218", "EMAPA:32654", "FMA:24925", "MA:0000042", "SCTID:370638006" ; oboInOwl:hasExactSynonym "distal segment of hand proper", "metacarpal part of hand", "metacarpal part of manus", "metacarpal region", "metacarpus" ; oboInOwl:hasNarrowSynonym "forelimb cannon region", "forelimb equine cannon region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004453" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpus region" ; rdfs:subClassOf obo:UBERON_0005451, [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010544 ], _:genid136057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009877 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg"^^xsd:anyURI . obo:UBERON_0004454 obo:IAO_0000115 "Mesopodial segment of the pes, including the tarsal skeleton and associated tissues." ; obo:IAO_0000232 "this term refers to the limb segment. See also: tarsal bones and tarsal skeleton" ; obo:UBPROP_0000012 "MA has both tarsus (part of foot, has tarsal bone) and ankle (part of hindlimb, has joint, nerve, skin)." ; oboInOwl:hasAlternativeId "UBERON:0002388" ; oboInOwl:hasDbXref "CALOHA:TS-2219", "EFO:0001409", "EMAPA:32783", "FMA:9665", "GAID:41", "MA:0000043", "MESH:D000842", "SCTID:361292008", "Wikipedia:Ankle", "galen:Ankle" ; oboInOwl:hasExactSynonym "ankle", "ankle region", "tarsal limb segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulatio talocruralis", "hind basipodium", "hind mesopodium", "hock" ; oboInOwl:id "UBERON:0004454" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "tarsal region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0000983 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0003823 ] ; owl:disjointWith obo:UBERON_0004772 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006716 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg"^^xsd:anyURI . obo:UBERON_0004455 obo:IAO_0000115 "An embryo at the neurula stage." ; oboInOwl:hasAlternativeId "UBERON:0007013" ; oboInOwl:hasDbXref "BILA:0000061", "BTO:0001766", "NCIT:C34229", "UMLS:C1518306" ; oboInOwl:hasExactSynonym "neurula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004455" ; a owl:Class ; rdfs:label "neurula embryo" ; rdfs:subClassOf obo:UBERON_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004734 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000110 ] ) ] . obo:UBERON_0004456 obo:IAO_0000115 "Sum of all sensory systems in an organism." ; obo:UBPROP_0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" ; oboInOwl:hasDbXref "FMA:78499" ; oboInOwl:hasExactSynonym "sense organ system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004456" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "entire sense organ system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:disjointWith obo:UBERON_8450002 . obo:UBERON_0004461 obo:IAO_0000115 "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18171", "FMA:71287" ; oboInOwl:hasExactSynonym "head musculature", "muscle group of head", "muscles of head", "musculi capitis", "set of muscles of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004461" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:comment "This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376" ; rdfs:label "skeletal musculature of head" ; rdfs:seeAlso "https://github.com/obophenotype/mouse-anatomy-ontology/issues/4"^^xsd:anyURI, "https://github.com/obophenotype/uberon/issues/1405"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013700 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005253 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:UBERON_0004462 obo:IAO_0000115 "Any collection of muscles that is part of a body wall [Automatically generated definition]." ; obo:UBPROP_0000008 "define generically to encompass both vertebrates and invertebrates" ; oboInOwl:hasDbXref "BSA:0000058", "BTO:0001863", "EMAPA:37853", "FMA:86931", "WBbt:0005813" ; oboInOwl:hasExactSynonym "body wall musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body wall muscles" ; oboInOwl:id "UBERON:0004462" ; a owl:Class ; rdfs:label "musculature of body wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000309 ] ) ] . obo:UBERON_0004463 obo:IAO_0000115 "Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:50208" ; oboInOwl:hasExactSynonym "muscle group of thigh", "musculature of thigh", "set of muscles of thigh", "thigh musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004463" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of hindlimb stylopod" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0004464 obo:IAO_0000115 "Any collection of muscles that is part of a thorax [Automatically generated definition]." ; obo:UBPROP_0000012 "BTO and FMA do not mean precisely the same thing here. BTO thorax muscle is a pectoral muscle or diaphragm" ; oboInOwl:hasDbXref "BTO:0000508", "EMAPA:37260", "FMA:71293" ; oboInOwl:hasExactSynonym "muscle group of thorax", "muscles of thorax", "musculi thoracis", "set of muscles of thorax", "thoracic musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004464" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of thorax" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0004465 obo:IAO_0000115 "Any collection of muscles that is part of a neck [Automatically generated definition]." ; oboInOwl:hasDbXref "AAO:0000091", "EMAPA:36050", "FMA:71290", "MESH:D009334" ; oboInOwl:hasExactSynonym "cervical muscles", "muscle group of neck", "muscles of neck", "musculi cervicis", "musculi colli", "neck musculature", "set of muscles of neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004465" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of neck" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0004466 obo:IAO_0000115 "Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition]." ; obo:UBPROP_0000013 "see notes on UBERON:0000978 for possible confusion over the term 'leg'. This class represents the class-union of upper leg musculature and lower leg musculature (and thus may not mean precisely the same thing as the EHDAA2 class)" ; oboInOwl:hasAlternativeId "UBERON:0005632" ; oboInOwl:hasDbXref "EHDAA2:0000973" ; oboInOwl:hasExactSynonym "leg muscle system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004466" ; a owl:Class ; rdfs:label "musculature of leg" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0004467 obo:IAO_0000115 "The collection of muscles that acts on the pharynx." ; oboInOwl:hasDbXref "FMA:264609", "TAO:0001307", "ZFA:0001307" ; oboInOwl:hasExactSynonym "pharyngeal musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of muscles of pharynx" ; oboInOwl:id "UBERON:0004467" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:comment "See comments for 'pharyngeal muscle'" ; rdfs:label "musculature of pharynx" ; rdfs:subClassOf obo:UBERON_0001015, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001042 ] . obo:UBERON_0004468 oboInOwl:hasDbXref "FMA:33061" ; oboInOwl:hasExactSynonym "muscle group of vertebral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004468" ; a owl:Class ; rdfs:label "set of muscles of vertebral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] . obo:UBERON_0004469 obo:IAO_0000115 "Any collection of muscles that is part of a back [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:71291" ; oboInOwl:hasExactSynonym "muscle group of back", "muscles of back", "musculi dorsi", "set of muscles of back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004469" ; a owl:Class ; rdfs:label "musculature of back" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0004470 obo:IAO_0000115 "Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]." ; obo:UBPROP_0000012 "we merge two FMA classes here" ; oboInOwl:hasAlternativeId "UBERON:0004485", "UBERON:0005633" ; oboInOwl:hasDbXref "AAO:0000427", "EHDAA2:0001429", "EMAPA:18184", "FMA:50205", "FMA:50248" ; oboInOwl:hasExactSynonym "muscle group of pelvic girdle", "muscle group of pelvis", "pelvic girdle muscle system", "pelvic girdle muscles", "pelvic girdle musculature", "set of muscles of pelvic girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular system of pelvis", "set of muscles of pelvis" ; oboInOwl:id "UBERON:0004470" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of pelvic girdle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001271 ] ) ] . obo:UBERON_0004471 obo:IAO_0000115 "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." ; oboInOwl:hasDbXref "AAO:0000423", "EMAPA:37857", "FMA:33519" ; oboInOwl:hasExactSynonym "muscle group of pectoral girdle", "pectoral girdle muscles", "pectoral girdle musculature", "set of muscles of pectoral girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004471" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of pectoral girdle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_0004473 obo:IAO_0000115 "Any collection of muscles that is part of a face." ; obo:IAO_0000116 "originally created to reflect the distinction drawn in FMA between a facial muscle and the entire musculature of the face. However, naming both does not serve any particular purpose" ; oboInOwl:hasDbXref "FMA:71288" ; oboInOwl:hasExactSynonym "entire facial musculature", "facial muscles", "muscle group of face", "musculi faciei" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of facial muscles", "set of muscles of face" ; oboInOwl:id "UBERON:0004473" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of face" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] . obo:UBERON_0004474 obo:IAO_0000115 "Any collection of muscles that is part of an arm [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000141" ; oboInOwl:hasExactSynonym "arm muscle system", "arm musculature", "muscle group of arm", "set of muscles of arm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004474" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of arm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 ] ) ] . obo:UBERON_0004475 obo:IAO_0000115 "The collection of muscles that form attachments to the hip skeleton." ; oboInOwl:hasDbXref "FMA:50227" ; oboInOwl:hasExactSynonym "hip musculature", "muscle group of hip", "set of muscles of hip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004475" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of hip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001464 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0008202 ] ) ] . obo:UBERON_0004476 obo:IAO_0000115 "The collection of muscles that form attachments to the shoulder skeleton." ; oboInOwl:hasDbXref "FMA:50220" ; oboInOwl:hasExactSynonym "muscle group of shoulder", "set of muscles of shoulder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004476" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of shoulder" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001467 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003461 ] ) ] . obo:UBERON_0004478 obo:IAO_0000115 "The collection of muscles that are part of the larynx." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "FMA:264611", "FMA:46616", "MESH:D007821", "Wikipedia:Muscles_of_larynx" ; oboInOwl:hasExactSynonym "laryngeal muscles", "laryngeal muscles set", "muscle group of larynx", "set of laryngeal muscles", "set of muscles of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004478" ; a owl:Class ; rdfs:label "musculature of larynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0004479 obo:IAO_0000115 "Any collection of muscles that is part of a trunk [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "AAO:0011572", "EFO:0003531", "FMA:50187" ; oboInOwl:hasExactSynonym "muscle group of trunk", "set of muscles of trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular system of trunk" ; oboInOwl:id "UBERON:0004479" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "musculature of trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0004480 obo:IAO_0000115 "Any collection of muscles that is part of a limb [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasAlternativeId "UBERON:0005635" ; oboInOwl:hasDbXref "EHDAA2:0000995", "EMAPA:32700", "FMA:50188" ; oboInOwl:hasExactSynonym "limb muscle system", "limb musculature", "muscle group of limb", "set of muscles of limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004480" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0004481 obo:IAO_0000115 "Any collection of muscles that is part of a forelimb [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "FMA:50396" ; oboInOwl:hasExactSynonym "free upper limb musculature", "muscle group of free upper limb", "musculature of free upper limb", "set of muscles of free upper limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004481" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of upper limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0004482 obo:IAO_0000115 "Any collection of muscles that is part of a hindlimb [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "FMA:50399" ; oboInOwl:hasExactSynonym "free lower limb musculature", "muscle group of free lower limb", "musculature of free lower limb", "set of muscles of free lower limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004482" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of lower limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0004486 obo:IAO_0000115 "Any collection of muscles that is part of a perineum [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "EMAPA:36629", "FMA:71295" ; oboInOwl:hasExactSynonym "musculi perinei", "perineal muscles", "perineal muscles set", "set of perineal muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004486" ; a owl:Class ; rdfs:label "musculature of perineum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002356 ] ) ] . obo:UBERON_0004487 obo:IAO_0000115 "Any collection of muscles that is part of a lower arm [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:39089" ; oboInOwl:hasExactSynonym "muscle group of forearm", "musculature of forearm", "set of muscles of forearm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004487" ; a owl:Class ; rdfs:label "musculature of forelimb zeugopod" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0004488 obo:IAO_0000115 "Any collection of muscles that is part of a foot [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "FMA:50214" ; oboInOwl:hasExactSynonym "foot musculature", "muscle group of foot", "musculature of foot", "set of muscles of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004488" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0004489 obo:IAO_0000115 "Any collection of muscles that is part of a manus [Automatically generated definition]." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "FMA:42368" ; oboInOwl:hasExactSynonym "hand musculature", "muscle group of hand", "musculature of hand", "set of muscles of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004489" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0004490 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." ; obo:UBPROP_0000012 "in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging." ; oboInOwl:hasDbXref "FMA:7283" ; oboInOwl:hasExactSynonym "atrial cardiac muscle tissue", "atrial heart muscle", "cardiac atrium muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "atrial myocardium" ; oboInOwl:id "UBERON:0004490" ; a owl:Class ; rdfs:label "cardiac muscle tissue of atrium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002302 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ] . obo:UBERON_0004491 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:84083" ; oboInOwl:hasExactSynonym "interatrial septum cardiac muscle tissue", "interatrial septum heart muscle", "interatrial septum muscle", "interatrial septum myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004491" ; a owl:Class ; rdfs:label "cardiac muscle tissue of interatrial septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002085 ] ) ] . obo:UBERON_0004492 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:226279" ; oboInOwl:hasExactSynonym "cardiac septum cardiac muscle tissue", "cardiac septum heart muscle", "cardiac septum muscle", "cardiac septum myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004492" ; a owl:Class ; rdfs:label "cardiac muscle tissue of cardiac septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002099 ] ) ] . obo:UBERON_0004493 obo:IAO_0000115 "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." ; obo:IAO_0000116 "Note placement of MA class based on parthood relationship" ; oboInOwl:hasDbXref "EMAPA:32688", "FMA:261726", "MA:0002441" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004493" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cardiac muscle tissue of myocardium" ; rdfs:subClassOf _:genid136345 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002349 ] ) ] . obo:UBERON_0004495 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261898" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004495" ; a owl:Class ; rdfs:label "skeletal muscle tissue of diaphragm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] . obo:UBERON_0004498 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a quadriceps femoris [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261998" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004498" ; a owl:Class ; rdfs:label "skeletal muscle tissue of quadriceps femoris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001377 ] ) ] . obo:UBERON_0004499 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a tibialis anterior [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:262004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004499" ; a owl:Class ; rdfs:label "skeletal muscle tissue of tibialis anterior" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001385 ] ) ] . obo:UBERON_0004500 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a deltoid [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261732" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle tissue of deltoid muscle" ; oboInOwl:id "UBERON:0004500" ; a owl:Class ; rdfs:label "skeletal muscle tissue of deltoid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001476 ] ) ] . obo:UBERON_0004502 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a biceps brachii [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261974" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle tissue of biceps brachii muscle" ; oboInOwl:id "UBERON:0004502" ; a owl:Class ; rdfs:label "skeletal muscle tissue of biceps brachii" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001507 ] ) ] . obo:UBERON_0004503 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a digastric [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261872" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004503" ; a owl:Class ; rdfs:label "skeletal muscle tissue of digastric" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001562 ] ) ] . obo:UBERON_0004504 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a mylohyoid [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261878" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004504" ; a owl:Class ; rdfs:label "skeletal muscle tissue of mylohyoid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001564 ] ) ] . obo:UBERON_0004505 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a orbicularis oculi [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261812" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004505" ; a owl:Class ; rdfs:label "skeletal muscle tissue of orbicularis oculi" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001578 ] ) ] . obo:UBERON_0004506 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a masseter [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261824" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004506" ; a owl:Class ; rdfs:label "skeletal muscle tissue of masseter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0004507 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a temporalis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261740" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004507" ; a owl:Class ; rdfs:label "skeletal muscle tissue of temporalis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001598 ] ) ] . obo:UBERON_0004508 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a levator palpebrae superioris [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261782" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004508" ; a owl:Class ; rdfs:label "skeletal muscle tissue of levator palpebrae superioris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001604 ] ) ] . obo:UBERON_0004509 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a trapezius [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261938" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle tissue of trapezius muscle" ; oboInOwl:id "UBERON:0004509" ; a owl:Class ; rdfs:label "skeletal muscle tissue of trapezius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002380 ] ) ] . obo:UBERON_0004510 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261968" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle tissue of pectoralis major muscle" ; oboInOwl:id "UBERON:0004510" ; a owl:Class ; rdfs:label "skeletal muscle tissue of pectoralis major" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002381 ] ) ] . obo:UBERON_0004511 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a rectus abdominis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261924" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004511" ; a owl:Class ; rdfs:label "skeletal muscle tissue of rectus abdominis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002382 ] ) ] . obo:UBERON_0004515 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261045" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004515" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle tissue of bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:UBERON_0004516 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:261051" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004516" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "smooth muscle tissue of terminal bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002187 ] ) ] . obo:UBERON_0004518 obo:IAO_0000115 "A muscle that is attached to a vertebra of the vertebral column." ; oboInOwl:hasDbXref "FMA:22594" ; oboInOwl:hasExactSynonym "vertebral column muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004518" ; a owl:Class ; rdfs:label "muscle of vertebral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002412 ] ) ] . obo:UBERON_0004519 obo:IAO_0000115 "Any muscle organ that is part of a anal part of perineum." ; oboInOwl:hasDbXref "FMA:77304" ; oboInOwl:hasExactSynonym "anal triangle muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004519" ; a owl:Class ; rdfs:label "muscle of anal triangle" ; rdfs:subClassOf obo:UBERON_0002379 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006867 ] ) ] . obo:UBERON_0004520 obo:IAO_0000115 "A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:45716" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004520" ; a owl:Class ; rdfs:label "striated muscle tissue of prostate" ; rdfs:subClassOf obo:UBERON_0001134 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid135230 ] . obo:UBERON_0004521 obo:IAO_0000115 "A vasculature that is part of a muscle organ [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:87123" ; oboInOwl:hasExactSynonym "muscular organ vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004521" ; a owl:Class ; rdfs:label "vasculature of muscle organ" ; owl:equivalentClass _:genid135234 . obo:UBERON_0004522 obo:IAO_0000115 "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:239607" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004522" ; a owl:Class ; rdfs:label "vasculature of musculoskeletal system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002204 ] ) ] . obo:UBERON_0004527 obo:IAO_0000115 "The thickened ridge of bone that contains the tooth sockets on the maxilla." ; obo:UBPROP_0000008 "In humans, the tooth-bearing bones are the maxilla and the mandible. The mineral content of alveolar bone is mostly hydroxyapatite, which is also found in enamel as the main inorganic substance" ; oboInOwl:hasAlternativeId "UBERON:0001696" ; oboInOwl:hasDbXref "AAO:0000396", "FMA:52897", "MA:0001492", "SCTID:245795005", "Wikipedia:Alveolar_process" ; oboInOwl:hasExactSynonym "alveolar margin of maxilla", "alveolar part of maxilla", "alveolar process of maxilla", "alveolar ridge of maxilla", "lower alveolar ridge", "maxilla alveolar process", "pars dentalis of maxilla", "posterior alveolar ridge", "processus alveolaris (maxilla)", "processus alveolaris maxillae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004527" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "alveolar process of maxilla" ; owl:disjointWith obo:UBERON_0004528 ; owl:equivalentClass _:genid135245 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray157.png"^^xsd:anyURI . obo:UBERON_0004528 obo:IAO_0000115 "The thickened ridge of bone that contains the tooth sockets on the mandible." ; oboInOwl:hasDbXref "FMA:52832", "SCTID:245791001", "Wikipedia:Alveolar_part_of_mandible" ; oboInOwl:hasExactSynonym "alveolar margin of mandible", "alveolar part of mandible", "alveolar process of mandible", "anterior alveolar ridge", "pars alveolaris (mandibula)", "upper alveolar ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alveolar arch of mandible", "pars alveolaris mandibulae" ; oboInOwl:id "UBERON:0004528" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "alveolar ridge of mandible" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004103 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Mandibule.jpg"^^xsd:anyURI . obo:UBERON_0004529 obo:IAO_0000115 "A projection or outgrowth of tissue from a larger body or organ." ; obo:IAO_0000116 "should be declared disjoint from organ, but in some ontologies (e.g. ZFA), structures such as neural spines are classified as bones (and hence organs)" ; obo:RO_0002175 obo:NCBITaxon_33090 ; obo:UBPROP_0000001 "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, or tissue.[AAO]", "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[TAO]", "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[VSAO]" ; oboInOwl:hasBroadSynonym "anatomical process", "process" ; oboInOwl:hasDbXref "AAO:0010278", "FMA:67601", "HAO:0000822", "NCIT:C61549", "TAO:0001834", "VSAO:0000180", "Wikipedia:Process_(anatomy)", "XAO:0004020", "galen:Ridge" ; oboInOwl:hasExactSynonym "processus", "projection" ; oboInOwl:hasNarrowSynonym "flange", "flanges", "lamella", "lamellae", "lamina", "laminae", "organ process", "papilla", "process of organ", "processes", "projection", "projections", "ridge", "ridges", "shelf", "shelves" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomical protrusion", "protrusion", "spine" ; oboInOwl:id "UBERON:0004529" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical projection" ; rdfs:subClassOf obo:UBERON_0034768, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000062 ] . obo:UBERON_0004530 obo:IAO_0000115 "Anatomical projection that is composed of bone tissue." ; oboInOwl:hasDbXref "FMA:75433", "ZFA:0001637" ; oboInOwl:hasExactSynonym "bone process", "projection of bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bony projections" ; oboInOwl:id "UBERON:0004530" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "bony projection" ; rdfs:subClassOf _:genid135287 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_4100000 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0004533 obo:IAO_0000115 "A testis that is in the left side of the genitalia [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37370", "FMA:7212", "MA:0001746", "NCIT:C49323", "SCTID:367720001", "UMLS:C0227998" ; oboInOwl:hasExactSynonym "left testicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004533" ; a owl:Class ; rdfs:label "left testis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000473 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000990 ] ) ] . obo:UBERON_0004534 obo:IAO_0000115 "A testis that is in the right side of the genitalia [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37371", "FMA:7211", "MA:0001747", "NCIT:C49326", "SCTID:367719007", "UMLS:C0227997" ; oboInOwl:hasExactSynonym "right testicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004534" ; a owl:Class ; rdfs:label "right testis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000473 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000990 ] ) ] . obo:UBERON_0004535 obo:IAO_0000115 "Anatomical system that has as its parts the heart and blood vessels." ; obo:IAO_0000232 "we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph." ; obo:UBPROP_0000003 "The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011001", "BILA:0000016", "BTO:0000088", "CALOHA:TS-1297", "EFO:0000791", "EHDAA2:0000216", "EHDAA:394", "EMAPA:16104", "EMAPA:16370", "EV:0100017", "FMA:7161", "GAID:467", "MA:0000010", "MAT:0000016", "MESH:D002319", "MIAA:0000016", "NCIT:C12686", "SCTID:278198007", "TAO:0000010", "UMLS:C0007226", "VHOG:0000302", "WikipediaCategory:Cardiovascular_system", "XAO:0000100", "XAO:0001010", "ZFA:0000010" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "CV system", "Herz und Gefaesssystem" ; oboInOwl:id "UBERON:0004535" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "cardiovascular system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0004536 obo:IAO_0000115 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." ; obo:IAO_0000116 "consider merging with parent" ; obo:UBPROP_0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" ; oboInOwl:hasDbXref "FMA:63815", "TAO:0005105", "ZFA:0005105" ; oboInOwl:hasExactSynonym "lymphatic trunks and ducts", "lymphatic vasculature", "lymphatic vessel network", "lymphatic vessels set", "set of lymphatic vessels", "trunci et ductus lymphatici" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph vessels" ; oboInOwl:id "UBERON:0004536" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "lymph vasculature" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006558 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002391 ] ) ] . obo:UBERON_0004537 obo:IAO_0000115 "A vascular network consisting of blood vessels." ; oboInOwl:hasDbXref "TAO:0001079", "ZFA:0001079" ; oboInOwl:hasExactSynonym "blood vascular network", "set of blood vessels" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blood system", "blood vessel system", "blood vessels" ; oboInOwl:id "UBERON:0004537" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "blood vasculature" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0004538 obo:IAO_0000115 "A kidney that is part of a left side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:36589", "FMA:7205", "MA:0001655", "NCIT:C34006", "SCTID:362209008", "UMLS:C0227614" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004538" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left kidney" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002113 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0004539 obo:IAO_0000115 "A kidney that is part of a right side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:36590", "FMA:7204", "MA:0001683", "NCIT:C34005", "SCTID:362208000", "UMLS:C0227613" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004539" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right kidney" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002113 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0004544 obo:IAO_0000115 "The layer of secretory cells which lines the epididymis." ; oboInOwl:hasDbXref "BTO:0005768", "CALOHA:TS-2063", "EMAPA:30445", "FMA:19153", "MA:0002825" ; oboInOwl:hasExactSynonym "epididymis epithelium", "epithelium of epididymis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004544" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epididymis epithelium" ; rdfs:subClassOf _:genid135354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000485 _:genid135352 ) ] . obo:UBERON_0004548 obo:IAO_0000115 "An eye that is part of a left side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37362", "FMA:12515", "MA:0002949", "NCIT:C119334", "SCTID:362503005" ; oboInOwl:hasExactSynonym "left eyeball" ; oboInOwl:hasNarrowSynonym "left orbital part of face", "left orbital region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004548" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000970 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0004549 obo:IAO_0000115 "An eye that is part of a right side of organism [Automatically generated definition]." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:37363", "FMA:12514", "MA:0002950", "NCIT:C119333", "SCTID:362502000" ; oboInOwl:hasExactSynonym "right eyeball" ; oboInOwl:hasNarrowSynonym "right orbital part of face", "right orbital region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004549" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000970 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0004552 obo:IAO_0000115 "An artery that is part of a digit [Automatically generated definition]." ; obo:IAO_0000116 "check part_of - do we need term for digit + metacarpal/tarsal bones?" ; oboInOwl:hasDbXref "EMAPA:37076", "MA:0001941", "SCTID:181335004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004552" ; a owl:Class ; rdfs:label "digital artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] . obo:UBERON_0004553 obo:IAO_0000115 "A digital artery that is part of a forelimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37210", "MA:0001953", "SCTID:265791006" ; oboInOwl:hasExactSynonym "digital artery of manus", "forelimb digital arteries" ; oboInOwl:hasNarrowSynonym "wing digital artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004553" ; a owl:Class ; rdfs:label "forelimb digital artery" ; rdfs:subClassOf _:genid136602 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004552 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0004554 obo:IAO_0000115 "A digital artery that is part of a hindlimb [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37214", "FMA:69713", "MA:0001964" ; oboInOwl:hasExactSynonym "digital artery of foot", "hindlimb digital arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004554" ; a owl:Class ; rdfs:label "hindlimb digital artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004552 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0004571 obo:IAO_0000115 "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." ; oboInOwl:hasDbXref "FMA:45623", "Wikipedia:Systemic_circulation#Arteries" ; oboInOwl:hasExactSynonym "systemic arterial circulatory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004571" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "systemic arterial system" ; rdfs:subClassOf obo:UBERON_0007798, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004572 ] . obo:UBERON_0004572 obo:IAO_0000115 "The part of the cardiovascular system consisting of all arteries." ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0004690", "EHDAA2:0000143", "EHDAA:396", "EMAPA:16201", "EMAPA:16371", "MA:0002719", "SCTID:362030008", "VHOG:0000273" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004572" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "arterial system" ; rdfs:subClassOf obo:UBERON_0007798, [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0001637 ], _:genid136621 . obo:UBERON_0004573 obo:IAO_0000115 "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." ; oboInOwl:hasDbXref "EMAPA:37126", "FMA:66464", "Wikipedia:Artery#Systemic_arteries" ; oboInOwl:hasExactSynonym "systemic arterial subtree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004573" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "systemic artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004571 ] ) ] . obo:UBERON_0004581 obo:IAO_0000115 "The part of the venous system that drains the general body tissues[Kardong]." ; obo:UBPROP_0000001 "In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP]", "Subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava[FMA]" ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; oboInOwl:hasDbXref "FMA:45626", "Wikipedia:Systemic_venous_system" ; oboInOwl:hasExactSynonym "systemic venous circulatory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004581" ; a owl:Class ; rdfs:label "systemic venous system" ; rdfs:subClassOf obo:UBERON_0002049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004582 ] . obo:UBERON_0004582 obo:IAO_0000115 "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." ; obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0004692", "EHDAA2:0002171", "EHDAA:486", "EMAPA:16240", "MA:0002720", "NCIT:C33858", "SCTID:362060003", "UMLS:C1267406", "VHOG:0000277" ; oboInOwl:hasExactSynonym "vein system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004582" ; a owl:Class ; rdfs:label "venous system" ; rdfs:subClassOf obo:UBERON_0007798, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001638 ] . obo:UBERON_0004590 obo:IAO_0000115 "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." ; obo:UBPROP_0000012 "FMA class is not a subtype of muscle" ; oboInOwl:hasDbXref "FMA:75004", "NCIT:C28381", "UMLS:C1409894", "Wikipedia:Sphincter" ; oboInOwl:hasExactSynonym "sphincter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "circular muscle" ; oboInOwl:id "UBERON:0004590" ; a owl:Class ; rdfs:label "sphincter muscle" ; rdfs:subClassOf obo:UBERON_0001630 . obo:UBERON_0004601 obo:IAO_0000115 "The first rib of the rib cage." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; obo:UBPROP_0000106 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19529", "FMA:7597", "MA:0001401", "NCIT:C52770", "SCTID:182016005", "UMLS:C1709945", "Wikipedia:First_rib" ; oboInOwl:hasExactSynonym "costa I", "costa prima (I)", "costa prima [I]", "first rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "costa prima" ; oboInOwl:id "UBERON:0004601" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "rib 1" ; rdfs:subClassOf obo:UBERON_0002228 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray124.png"^^xsd:anyURI . obo:UBERON_0004611 obo:IAO_0000115 "In humans: The twelfth rib has a single articular facet on the head, which is of rather large size. It has no necks or tubercles, and is pointed at its anterior ends. The twelfth has angle nor costal groove; it is much shorter than the eleventh rib, and its head is inclined slightly downward. Sometimes the twelfth rib is even shorter than the first rib. [WP,unvetted]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; obo:UBPROP_0000106 "12"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19540", "FMA:8515", "MA:0001412", "NCIT:C52767", "SCTID:244667008", "UMLS:C1709948", "Wikipedia:Twelfth_rib" ; oboInOwl:hasExactSynonym "costa XII", "twelfth rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004611" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "rib 12" ; rdfs:subClassOf obo:UBERON_0002228 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray128.png"^^xsd:anyURI . obo:UBERON_0004612 obo:IAO_0000115 "The third of the seven cervical vertebrae[ncit,modified]." ; obo:IAO_0000116 "under discussion: whether to generalize this beyond mammals, making it purely order-defined" ; obo:IAO_0000232 "elements are to be defined spatially/topologically. all mammals have 7 cervical vertebrae" ; obo:UBPROP_0000107 "3"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19433", "FMA:12521", "MA:0001423", "NCIT:C32241", "SCTID:181823007", "UMLS:C0459939" ; oboInOwl:hasExactSynonym "C3 vertebra", "cervical vertebra 3", "cervical vertebrae 3", "third cervical vertebra", "third cervical vertebra of axial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004612" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mammalian cervical vertebra 3" ; rdfs:subClassOf obo:UBERON_0002413, _:genid136658 . obo:UBERON_0004613 obo:IAO_0000115 "The fourth of the seven cervical vertebrae[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically. all mammals have 7 cervical vertebrae" ; obo:UBPROP_0000107 "4"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19434", "FMA:12522", "MA:0001424", "NCIT:C32242", "SCTID:181824001", "UMLS:C0459941" ; oboInOwl:hasExactSynonym "C4 vertebra", "cervical vertebra 4", "fourth cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004613" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mammalian cervical vertebra 4" ; rdfs:subClassOf obo:UBERON_0002413, _:genid136667 . obo:UBERON_0004614 obo:IAO_0000115 "The fifth of the seven cervical vertebrae[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically. all mammals have 7 cervical vertebrae" ; obo:UBPROP_0000107 "5"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19435", "FMA:12523", "MA:0001425", "NCIT:C32243", "SCTID:181825000", "UMLS:C0459943" ; oboInOwl:hasExactSynonym "C5 vertebra", "cervical vertebra 5", "fifth cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004614" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mammalian cervical vertebra 5" ; rdfs:subClassOf obo:UBERON_0002413, _:genid136674 . obo:UBERON_0004615 obo:IAO_0000115 "The sixth of the seven cervical vertebrae[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically. all mammals have 7 cervical vertebrae" ; obo:UBPROP_0000107 "6"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:19466", "FMA:12524", "MA:0001426", "NCIT:C32244", "SCTID:181826004", "UMLS:C0459944" ; oboInOwl:hasExactSynonym "C6 vertebra", "cervical vertebra 6", "sixth cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004615" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "mammalian cervical vertebra 6" ; rdfs:subClassOf obo:UBERON_0002413, _:genid136681 . obo:UBERON_0004617 obo:IAO_0000115 "The first lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19472", "FMA:13072", "MA:0001428", "NCIT:C32899", "SCTID:181841004", "UMLS:C0223492" ; oboInOwl:hasExactSynonym "L1 vertebra", "first lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004617" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar vertebra 1" ; rdfs:subClassOf obo:UBERON_0002414 . obo:UBERON_0004618 obo:IAO_0000115 "The second lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19570", "FMA:13073", "MA:0001429", "NCIT:C32900", "SCTID:181842006", "UMLS:C0223507" ; oboInOwl:hasExactSynonym "L2 vertebra", "second lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004618" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lumbar vertebra 2" ; rdfs:subClassOf obo:UBERON_0002414, _:genid136692 . obo:UBERON_0004619 obo:IAO_0000115 "The third lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19571", "FMA:13074", "MA:0001430", "NCIT:C32901", "SCTID:181843001", "UMLS:C0223522" ; oboInOwl:hasExactSynonym "L3 vertebra", "third lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004619" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lumbar vertebra 3" ; rdfs:subClassOf obo:UBERON_0002414, _:genid136698 . obo:UBERON_0004620 obo:IAO_0000115 "The fourth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19572", "FMA:13075", "MA:0001431", "NCIT:C32902", "SCTID:181844007", "UMLS:C0223537" ; oboInOwl:hasExactSynonym "L4 vertebra", "fourth lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004620" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar vertebra 4" ; rdfs:subClassOf obo:UBERON_0002414, _:genid136704 . obo:UBERON_0004621 obo:IAO_0000115 "The fifth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." ; obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19573", "FMA:13076", "MA:0001432", "NCIT:C32903", "SCTID:181845008", "UMLS:C0223552" ; oboInOwl:hasExactSynonym "L5 vertebra", "fifth lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004621" ; oboInOwl:inSubset core:defined_by_ordinal_series, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lumbar vertebra 5" ; rdfs:subClassOf obo:UBERON_0002414, _:genid136710 . obo:UBERON_0004622 obo:IAO_0000232 "elements are to be defined spatially/topologically" ; oboInOwl:hasDbXref "EMAPA:19588", "FMA:13077", "MA:0001434", "NCIT:C33498", "SCTID:181846009", "UMLS:C0223598" ; oboInOwl:hasExactSynonym "S1 vertebra", "first sacral segment", "first sacral vertebra", "first segment of sacrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004622" ; oboInOwl:inSubset core:defined_by_ordinal_series ; a owl:Class ; rdfs:label "sacral vertebra 1" ; rdfs:subClassOf obo:UBERON_0001094 . obo:UBERON_0004637 obo:IAO_0000115 "The capsule surrounding the inner ear mechanism." ; obo:IAO_0000116 "developmental relationships need to be checked" ; obo:UBPROP_0000001 "Skeletal elements surrounding the membranous labyrinth of the inner ear. Sensory capsules anterolateral to and confluent with occipital arch.[AAO]", "The cartilage capsule surrounding the inner ear mechanism; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony. [Biology_online][VHOG]" ; obo:UBPROP_0000002 "relationship loss: part_of occipito-petrosal (AAO:0010831)[AAO]", "relationship loss: part_of otic and occipital (AAO:0000993)[AAO]" ; obo:UBPROP_0000003 "Otic capsules develop around the parts of the ear that lie within the chondrocranium. This part of the ear, known as the inner ear, is composed of the semicircular ducts and associated sacs that contain the receptive cells for equilibrium and hearing (reference 1); (...) considerations have led to our rethinking issues related to the origin of several aspects of vertebrate hearing, and to the view that many basic auditory functions evolved very early in vertebrate history, and that the functions observed in more `advanced' vertebrates, such as birds and mammals, are frequently modifications of themes first encountered in fishes, and perhaps even more ancestral animals.[well established][VHOG]" ; obo:UBPROP_0000008 "in elasmobranchs, it remains cartilaginous in the adult; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony (at approximately 23 weeks in humans)" ; oboInOwl:hasBroadSynonym "otic capsule skeletal element" ; oboInOwl:hasDbXref "AAO:0010143", "SCTID:361515007", "VHOG:0000854" ; oboInOwl:hasExactSynonym "otic capsule", "otic capsule element", "otic capsule endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory capsule", "otic region", "periotic", "periotic capsule" ; oboInOwl:id "UBERON:0004637" ; a owl:Class ; rdfs:label "otic capsule" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003110 ] . obo:UBERON_0004638 obo:IAO_0000115 "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart." ; oboInOwl:hasDbXref "BTO:0000766", "CALOHA:TS-2155", "EMAPA:35176", "MA:0000709", "NCIT:C53395", "TAO:0005257", "UMLS:C1706972", "ZFA:0005257" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004638" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "blood vessel endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0004639 obo:IAO_0000115 "The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism." ; oboInOwl:hasDbXref "EMAPA:28230", "EMAPA:28266", "FMA:77042", "MA:0002579", "SCTID:67498004", "TAO:0002139", "Wikipedia:Afferent_arterioles", "ZFA:0005307" ; oboInOwl:hasExactSynonym "afferent arteriole", "afferent glomerular arteriole", "afferent glomerular arteriole of kidney", "arteriola glomerularis afferens renis", "kidney afferent arteriole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriola glomerularis afferens" ; oboInOwl:id "UBERON:0004639" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "renal afferent arteriole" ; rdfs:subClassOf obo:UBERON_0001980, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001285 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0004723 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001229 ], _:genid136745 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png"^^xsd:anyURI . obo:UBERON_0004641 obo:IAO_0000115 "The connective tissue that surrounds the spleen." ; oboInOwl:hasDbXref "EMAPA:35802", "FMA:15849", "MA:0000753", "NCIT:C33598", "SCTID:329635002", "UMLS:C0229681" ; oboInOwl:hasExactSynonym "Malpighian capsule", "capsula splenica", "capsule of spleen", "fibroelastic coat of spleen", "fibrous capsule of spleen", "splenic capsule", "tunica fibrosa (splen)(lien)", "tunica fibrosa splenica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004641" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen capsule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0004646 obo:IAO_0000115 "The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37090", "FMA:49767", "MA:0001977", "NCIT:C52940", "SCTID:148167004", "UMLS:C0226153", "Wikipedia:Infraorbital_artery" ; oboInOwl:hasExactSynonym "infra-orbital artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "a. infraorbitalis" ; oboInOwl:id "UBERON:0004646" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "infraorbital artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray511.png"^^xsd:anyURI . obo:UBERON_0004647 obo:IAO_0000115 "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." ; obo:IAO_0000232 "should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.[WP]" ; oboInOwl:hasDbXref "EMAPA:35499", "FMA:14471", "MA:0002494", "NCIT:C32732", "SCTID:362194004", "UMLS:C0227518", "Wikipedia:Lobules_of_liver" ; oboInOwl:hasExactSynonym "hepatic lobule", "lobuli hepatici", "lobulus hepaticus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobules of liver", "lobuli hepatis" ; oboInOwl:id "UBERON:0004647" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "liver lobule" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000182 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001280 ], _:genid136778 . obo:UBERON_0004649 obo:IAO_0000115 "The process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes." ; obo:IAO_0000116 "TODO - check AAO:0000521-pterygoid and MA:0001471-pterygoid bone. MA also has 'inner plate of pterygoid process' as a syn for MA:0001471, FMA has lateral/medial plates. Seems likely inner = lateral (see MP:0004452)." ; obo:UBPROP_0000001 "Process that projects from posterior margin of commissure into subocular space.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of anterior quadratocranial commissure (AAO:0010061)[AAO]" ; oboInOwl:hasDbXref "AAO:0010086", "FMA:54682", "MA:0002774", "SCTID:140390001", "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; oboInOwl:hasExactSynonym "processus pterygoideus", "processus pterygoideus ossis sphenoidalis", "pterygoid process", "pterygoid process of sphenoid", "pterygoid process of sphenoid bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "processus pterygoideus ossis sphenoidalis", "pterygoid plate", "pterygoid process", "pterygoid process of sphenoid bone", "pterygoid processes", "pterygoid processus" ; oboInOwl:id "UBERON:0004649" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sphenoid bone pterygoid process" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001677 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001677 ], _:genid136790 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png"^^xsd:anyURI . obo:UBERON_0004650 obo:IAO_0000115 "A keratinized stratified squamous epithelium that is part of a tongue." ; oboInOwl:hasDbXref "FMA:74865", "MA:0002787" ; oboInOwl:hasExactSynonym "keratinized epithelium of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004650" ; a owl:Class ; rdfs:label "tongue keratinized epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012329 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0004652 obo:IAO_0000115 "The body or shaft of the humerus is almost cylindrical in the upper half of its extent, prismatic and flattened below, and has three borders and three surfaces." ; oboInOwl:hasDbXref "EMAPA:25051", "FMA:13305", "MA:0002807", "NCIT:C120671", "SCTID:181927007", "Wikipedia:Body_of_humerus" ; oboInOwl:hasExactSynonym "body of humerus", "corpus humeri", "diaphysis of humerus", "humeral diaphysis", "shaft of humerus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body of the humerus", "medial humerus", "shaft of the humerus" ; oboInOwl:id "UBERON:0004652" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "humerus diaphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_0004657 obo:IAO_0000115 "Articular part of the mandible bone." ; oboInOwl:hasDbXref "BTO:0001750", "EMAPA:36572", "FMA:52836", "GAID:219", "MA:0002816", "MESH:D008335", "MFMO:0000056", "Wikipedia:Condyloid_process" ; oboInOwl:hasExactSynonym "condylar process of mandible", "condyle of the mandible", "mandibular condyle", "processus condylaris", "processus condylaris mandibulae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "condyle of mandible", "condyle of the mandible", "condyloid process", "mandibular condyloid process" ; oboInOwl:id "UBERON:0004657" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mandible condylar process" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000401 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000401 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Processuscondylarismandibulae.PNG"^^xsd:anyURI . obo:UBERON_0004660 obo:IAO_0000115 "A dorsal process on the lower jaw associated with muscle attachment. It may be formed by a separate coronoid bone or as a process of the dentary. In most living (and many extinct) mammals, the most dorsal of the three proximal processes of the jaw." ; obo:UBPROP_0000012 "TAO:0001673 coronoid process, a bony projection on dentary" ; oboInOwl:hasBroadSynonym "coronoid" ; oboInOwl:hasDbXref "FMA:52833", "MA:0002819", "SCTID:244691004", "Wikipedia:Coronoid_process_of_the_mandible" ; oboInOwl:hasExactSynonym "coronoid process of mandible", "processus coronoideus (mandibula)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibular coronoid process", "processus coronoideus mandibulae" ; oboInOwl:id "UBERON:0004660" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mandible coronoid process" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000401 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000401 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Processuscoronoideusmandibulae.PNG"^^xsd:anyURI . obo:UBERON_0004663 obo:IAO_0000115 "An anatomical wall that is part of an aorta, enclosing the luminal space." ; oboInOwl:hasDbXref "EMAPA:35139", "FMA:14156", "MA:0002901" ; oboInOwl:hasExactSynonym "aortic wall", "wall of aorta" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004663" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta wall" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000947 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0004664 obo:IAO_0000115 "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers." ; oboInOwl:hasDbXref "EMAPA:35136", "FMA:14283", "MA:0002902", "SCTID:24996002" ; oboInOwl:hasExactSynonym "tunica adventitia of aorta" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004664" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta tunica adventitia" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004663 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004663 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005734 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0004665 obo:IAO_0000115 "A muscular coat that is part of a seminal vesicle [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:29773", "FMA:19404", "MA:0002913" ; oboInOwl:hasExactSynonym "muscle layer of seminal vesicle", "muscular coat of seminal gland", "muscular layer of seminal gland", "tunica muscularis (vesicula seminalis)", "tunica muscularis glandulae vesiculosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004665" ; a owl:Class ; rdfs:label "muscular coat of seminal vesicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:UBERON_0004666 obo:IAO_0000115 "The membranous portion of the wall between the two lower chambers of the heart." ; obo:UBPROP_0000001 "The membranous septum is the upper part of ventricular septum[GO:0003149]." ; oboInOwl:hasAlternativeId "UBERON:0004143" ; oboInOwl:hasBroadSynonym "membranous septum", "ventricle membranous septum", "ventricular membranous septum" ; oboInOwl:hasDbXref "EHDAA2:0004596", "EMAPA:18246", "FMA:7135", "MA:0002939", "SCTID:278228007", "VHOG:0000927" ; oboInOwl:hasExactSynonym "cardiac ventricular membranous septum", "membranous interventricular septum", "membranous part interventricular septum", "membranous part of interventricular septum", "membranous portion of interventricular septum", "pars membranacea (septi interventricularis)", "pars membranacea septi interventricularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "membranous interventricular septum" ; oboInOwl:id "UBERON:0004666" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interventricular septum membranous part" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002094 ], _:genid136879 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000158 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:UBERON_0004667 obo:IAO_0000115 "The muscular portion of the wall between the two lower chambers of the heart." ; obo:UBPROP_0000001 "The muscular septum is the lower part of the ventricular septum[GO]" ; oboInOwl:hasAlternativeId "UBERON:0004144" ; oboInOwl:hasBroadSynonym "muscular septum" ; oboInOwl:hasDbXref "EHDAA2:0000885", "EHDAA:2607", "EMAPA:18247", "FMA:7134", "MA:0002940", "RETIRED_EHDAA2:0000888" ; oboInOwl:hasExactSynonym "cardiac ventricular muscular septum", "muscular interventricular septum", "muscular part interventricular septum", "muscular part of interventricular septum", "pars muscularis (septi interventricularis)", "pars muscularis septi interventricularis", "septum membranaceum", "ventricular muscular septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular interventricular septum" ; oboInOwl:id "UBERON:0004667" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interventricular septum muscular part" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:UBERON_0004668 obo:IAO_0000115 "One of: the 4th ventricle median or lateral apertures." ; oboInOwl:hasDbXref "FMA:242766", "MA:0002945" ; oboInOwl:hasExactSynonym "aperture of 4th ventricle", "aperture of fourth ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004668" ; a owl:Class ; rdfs:label "fourth ventricle aperture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) ] . obo:UBERON_0004681 obo:IAO_0000115 "The sensory system for the sense of balance." ; obo:UBPROP_0000001 "The vestibular system, which contributes to our balance and our sense of spatial orientation, is the sensory system that provides the dominant input about movement and equilibrioception. Together with the cochlea, a part of the auditory system, it constitutes the labyrinth of the inner ear, situated in the vestibulum in the inner ear. As our movements consist of rotations and translations, the vestibular system comprises two components: the semicircular canal system, which indicate rotational movements; and the otoliths, which indicate linear accelerations. The vestibular system sends signals primarily to the neural structures that control our eye movements, and to the muscles that keep us upright. The projections to the former provide the anatomical basis of the vestibulo-ocular reflex, which is required for clear vision; and the projections to the muscles that control our posture are necessary to keep us upright[Wikipedia:Vestibular_system]." ; obo:UBPROP_0000012 "FMA and NIF have no part information for this class. This is a GAT in FMA" ; oboInOwl:hasDbXref "BTO:0003381", "EMAPA:37986", "FMA:7193", "NLXANAT:090819", "SCTID:361533001", "Wikipedia:Vestibular_system" ; oboInOwl:hasExactSynonym "vestibular organ system", "vestibular system" ; oboInOwl:hasNarrowSynonym "equilibrioception system", "vestibulomotor system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004681" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vestibular system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0060005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050957 ] ) ] . obo:UBERON_0004684 obo:IAO_0000115 "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." ; oboInOwl:hasDbXref "BAMS:RA", "EMAPA:35721", "FMA:84017", "MA:0003147", "MESH:D011903", "NCIT:C97335", "NLXANAT:20090205", "TAO:0001429", "UMLS:C0034671", "Wikipedia:Raphe_nuclei", "ZFA:0001429", "neuronames:2495" ; oboInOwl:hasExactSynonym "nuclei raphes", "raphe nuclei", "raphe nuclei set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei raphes", "raphe cluster", "raphe nucleus", "raphe of mesenchephalon", "set of raphe nuclei" ; oboInOwl:id "UBERON:0004684" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:comment "we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei'" ; rdfs:label "raphe nuclei" ; rdfs:subClassOf obo:UBERON_0002616, _:genid136928, _:genid136930 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png"^^xsd:anyURI . obo:UBERON_0004688 obo:IAO_0000115 "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:37496", "FMA:10636", "MA:0001939", "SCTID:244225009", "Wikipedia:Costocervical_trunk" ; oboInOwl:hasExactSynonym "costocervical trunk", "trunk of costocervical artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "truncus costocervicalis" ; oboInOwl:id "UBERON:0004688" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "costo-cervical trunk" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001533 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png"^^xsd:anyURI . obo:UBERON_0004692 obo:IAO_0000115 "An epithelium that is part of an external naris [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:18596", "MA:0001321" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004692" ; a owl:Class ; rdfs:label "external naris epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005928 ] ) ] . obo:UBERON_0004695 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36503", "MA:0000704" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004695" ; a owl:Class ; rdfs:label "arterial system smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004572 ] ) ] . obo:UBERON_0004696 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36613", "MA:0000715" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004696" ; a owl:Class ; rdfs:label "venous system smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004237 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004582 ] ) ] . obo:UBERON_0004698 obo:IAO_0000115 "An endothelium that is part of a vena cava [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37800", "MA:0000713", "NCIT:C49318", "UMLS:C1710623" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004698" ; a owl:Class ; rdfs:label "vena cava endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004087 ] ) ] . obo:UBERON_0004699 obo:IAO_0000115 "An endothelium that is part of a outflow tract [Automatically generated definition]." ; obo:UBPROP_0000003 "It is assumed that during evolution, a circulatory system composed of the heart and endothelial tubular system first formed in vertebrates, medial smooth muscle then appeared for regulation of the system, and innervation of the muscle tissue took place. This sequence of development assumed for phylogenesis is actually realized in the ontogenetic processes.[well established][VHOG]" ; oboInOwl:hasDbXref "MA:0000490", "VHOG:0001524" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004699" ; a owl:Class ; rdfs:label "outflow tract endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 ] ) ] . obo:UBERON_0004700 obo:IAO_0000115 "An endothelium that is part of an arterial system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35145", "MA:0000703", "NCIT:C49329", "UMLS:C1706849" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004700" ; a owl:Class ; rdfs:label "arterial system endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004572 ] ) ] . obo:UBERON_0004701 obo:IAO_0000115 "An endothelium that is part of a venous system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35907", "MA:0000714", "NCIT:C49320", "UMLS:C1710626" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004701" ; a owl:Class ; rdfs:label "venous system endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004582 ] ) ] . obo:UBERON_0004702 obo:IAO_0000115 "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35732", "MA:0001805" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004702" ; a owl:Class ; rdfs:label "respiratory system blood vessel endothelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003504 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004703 obo:IAO_0000116 "TODO. http://www.ncbi.nlm.nih.gov/pubmed/8167659" ; oboInOwl:hasDbXref "BAMS:DOR", "BAMS:Dorsal_thalamus", "BM:Die-Th", "DHBA:10391", "DMBA:16396", "EHDAA2:0000692", "EMAPA:35295", "FMA:62007", "HBA:4393", "MA:0000180", "PBA:128013018", "TAO:0000653", "ZFA:0000653", "ncithesaurus:Dorsal_Thalamus", "neuronames:1455" ; oboInOwl:hasExactSynonym "dorsal thalamus", "dorsal thalamus (Anthoney)", "thalamus dorsalis", "thalamus proper", "thalamus, pars dorsalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal tier of thalamus" ; oboInOwl:id "UBERON:0004703" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal thalamus" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001897 ] . obo:UBERON_0004704 obo:IAO_0000115 "A depression or hollow in a bone[WP]." ; obo:UBPROP_0000001 "Anatomical space that is a concavity, shallow depression, or groove on a bone.[TAO]" ; obo:UBPROP_0000012 "General Anatomical term in FMA; not restricted to bone in ncit; surface feature in VSAO; note that entities named 'fossa' are cavities in FMA, hence placement here" ; oboInOwl:hasBroadSynonym "fossa" ; oboInOwl:hasDbXref "AAO:0010439", "FMA:45791", "TAO:0001743", "UMLS:C0836913", "VSAO:0005069", "Wikipedia:Fossa#Anatomy", "ZFA:0005388" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "concavities", "concavity", "depression", "depressions", "fossae", "groove" ; oboInOwl:id "UBERON:0004704" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "bone fossa" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] . obo:UBERON_0004706 obo:IAO_0000115 "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." ; obo:IAO_0000116 "TODO - check relationship to bulbus arteriosus" ; obo:UBPROP_0000001 "A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO]" ; oboInOwl:hasDbXref "EHDAA2:0000197", "EHDAA:438", "EHDAA:768", "EMAPA:16333", "FMA:70300", "NCIT:C34114", "SCTID:361525002", "UMLS:C1284055", "Wikipedia:Bulbus_cordis" ; oboInOwl:hasExactSynonym "primitive right ventricle endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004706" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "bulbus cordis" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png"^^xsd:anyURI . obo:UBERON_0004707 obo:IAO_0000115 "A stage that follows the blastula, gastrula and neurula stages. At the pharyngula stage, all vertebrate embryos show remarkable similarities." ; obo:UBPROP_0000008 "Corresponds to E7-E11 in Mouse (Galis et al, TREE, 2001)" ; oboInOwl:hasDbXref "DrerDO:0000052", "EFO:0001310", "OGES:000006", "Wikipedia:Pharyngula", "ZFS:0000050" ; oboInOwl:hasExactSynonym "phylotypic stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngula" ; oboInOwl:id "UBERON:0004707" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "pharyngula stage" ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000111 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000110 ] . obo:UBERON_0004708 obo:IAO_0000115 "An appendage that is part of an appendage girdle complex." ; obo:IAO_0000232 "this class is the union of the classes limb, pectoral fin and pelvic fin." ; oboInOwl:hasAlternativeId "UBERON:0009872" ; oboInOwl:hasDbXref "VSAO:0000067" ; oboInOwl:hasExactSynonym "girdle-associated appendage", "limb or fin", "limb/fin", "pectoral or pelvic appendage", "pelvic/pectoral appendage" ; oboInOwl:hasNarrowSynonym "jointed paired lateral appendage", "paired appendage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004708" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "paired limb/fin" ; rdfs:subClassOf obo:UBERON_0000026, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000014 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001015 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002049 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0007823 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011582 ], _:genid137027, _:genid137033 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000026 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] . obo:UBERON_0004709 obo:IAO_0000115 "Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues." ; oboInOwl:hasAlternativeId "UBERON:0009876" ; oboInOwl:hasBroadSynonym "posterior appendage" ; oboInOwl:hasDbXref "VSAO:0000126" ; oboInOwl:hasExactSynonym "hindlimb/pelvic fin", "pelvic appendage", "pelvic limb/fin", "posterior limb/fin", "posterior paired appendage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004709" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "pelvic appendage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001271 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0007273 ], _:genid137049 ; owl:disjointWith obo:UBERON_0004710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_0004710 obo:IAO_0000115 "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." ; obo:UBPROP_0000003 "While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0009875" ; oboInOwl:hasBroadSynonym "anterior appendage" ; oboInOwl:hasDbXref "VHOG:0001753", "VSAO:0000125" ; oboInOwl:hasExactSynonym "anterior limb/fin", "anterior paired appendage", "forelimb - pectoral fin", "forelimb or pectoral fin", "forelimb/pectoral fin", "pectoral limb/fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004710" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "pectoral appendage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001421 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0007272 ], _:genid137063 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004708 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_0004711 obo:IAO_0000115 "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava." ; oboInOwl:hasDbXref "BTO:0001744", "CALOHA:TS-0497", "EMAPA:18638", "GAID:536", "MA:0002154", "MESH:D007601", "NCIT:C12738", "SCTID:244403000", "UMLS:C0022427", "Wikipedia:Jugular_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "jugular", "vena jugularis" ; oboInOwl:id "UBERON:0004711" ; a owl:Class ; rdfs:label "jugular vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000033 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png"^^xsd:anyURI . obo:UBERON_0004713 obo:IAO_0000115 "One of the columns of erectile tissue forming the dorsum and sides of the penis." ; oboInOwl:hasBroadSynonym "corpus cavernosum", "penis erectile tissue" ; oboInOwl:hasDbXref "BTO:0002019", "EMAPA:29850", "EMAPA:29856", "FMA:19618", "MA:0001743", "NCIT:C32382", "NCIT:C49269", "SCTID:245468004", "UMLS:C0227937", "UMLS:C1709494", "Wikipedia:Corpus_cavernosum_penis" ; oboInOwl:hasExactSynonym "corpus cavernosum of penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavernous body of penis", "corpus cavernosum penis", "corpus spongiosum penis", "penile corpus cavernosum", "spongy body of male urethra", "spongy body of penis" ; oboInOwl:id "UBERON:0004713" ; a owl:Class ; rdfs:label "corpus cavernosum penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0043084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006609 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray1155.png"^^xsd:anyURI . obo:UBERON_0004714 obo:IAO_0000115 "A triangular double membrane, consisting of glial cells and fibers (Heimer, 1996) separating the anterior horns of the lateral ventricles of the brain. It is situated in the median plane and bounded by the corpus callosum and the body and columns of the fornix." ; oboInOwl:hasDbXref "BAMS:SptP", "BAMS:spt", "BIRNLEX:1315", "BTO:0003448", "DHBA:12098", "FMA:61844", "MA:0002979", "MESH:D012688", "NCIT:C33536", "SCTID:362313003", "UMLS:C0036700", "Wikipedia:Septum_pellucidum", "neuronames:256" ; oboInOwl:hasExactSynonym "septal pellucidum", "septum pellucidum of telencephalic ventricle", "supracommissural septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral septum", "pellucidum", "septum gliosum", "septum lucidum" ; oboInOwl:id "UBERON:0004714" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "septum pellucidum" ; rdfs:subClassOf obo:UBERON_0000119, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000446 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000446 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000125 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png"^^xsd:anyURI . obo:UBERON_0004715 obo:IAO_0000115 "The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." ; oboInOwl:hasBroadSynonym "annulus fibrosus" ; oboInOwl:hasDbXref "BTO:0003629", "EMAPA:32670", "FMA:13551", "MA:0000111", "Wikipedia:Annulus_fibrosus_disci_intervertebralis" ; oboInOwl:hasExactSynonym "anulus fibrosus (diskus intervertebralis)", "anulus fibrosus of intervertebral disk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "annulus fibrosus of intervertebral disc", "fibrous ring of intervertebral disc" ; oboInOwl:id "UBERON:0004715" ; a owl:Class ; rdfs:label "annulus fibrosus disci intervertebralis" ; owl:disjointWith obo:UBERON_0006008 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006444 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001066 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png"^^xsd:anyURI . obo:UBERON_0004716 obo:IAO_0000115 "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." ; obo:IAO_0000116 "EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus" ; oboInOwl:hasDbXref "AEO:0000194", "BTO:0003834", "EHDAA2:0000001", "EHDAA2:0003235", "EMAPA:36040", "NCIT:C34131", "UMLS:C1516779", "Wikipedia:Conceptus" ; oboInOwl:hasExactSynonym "embryo plus adnexa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004716" ; a owl:Class ; rdfs:label "conceptus" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002050 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0016887 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000365 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002493 ; owl:someValuesFrom obo:UBERON_0000068 ] . obo:UBERON_0004720 obo:IAO_0000115 "A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally)." ; obo:RO_0002171 obo:UBERON_0002245 ; obo:UBPROP_0000008 "In bony fish, or teleosts, it has been proposed that the cerebellar auricles, which receive a large amount of input from the vestibulolateral line system, constitute the vestibulocerebellum and are homologues of the flocculonodular lobe of higher vertebrates along with the corpus cerebelli, which receives spinocerebellar and tectocerebellar fibers. The labyrinth and the lateral line organs of lampreys have structural and functional similarity. An important difference between the two structures is that the arrangement of the lateral line organs are such that they are sensitive to relative motion of the fluid surrounding the animal, whereas the labyrinths, having very similar sensing mechanisms, are sensitive to endolymph, providing information concerning the animal's own equilibrium of the body and orientation in space" ; obo:UBPROP_0000012 "we follow MBA and NIFSTD in making this part of the cerebellar cortex, but FMA may handle this differently" ; oboInOwl:hasDbXref "BAMS:VERM", "BAMS:Ver", "BIRNLEX:1106", "BIRNLEX:1175", "CALOHA:TS-2059", "DHBA:10658", "DMBA:16814", "EMAPA:35214", "EV:0100298", "FMA:76928", "HBA:4698", "MA:0000202", "MBA:645", "MESH:D065814", "NCIT:C33866", "SCTID:279105006", "UMLS:C0228482", "Wikipedia:Cerebellar_vermis", "neuronames:2463" ; oboInOwl:hasExactSynonym "cerebellum vermis", "vermal parts of the cerebellum", "vermal regions", "vermis cerebelli [I-X]", "vermis of cerebellum", "vermis of cerebellum [I-X]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vermis", "vermis cerebelli" ; oboInOwl:id "UBERON:0004720" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "cerebellar vermis" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0002037 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004008 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0040011 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:NBO_0000355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002129 ], _:genid137126 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png"^^xsd:anyURI . obo:UBERON_0004723 obo:IAO_0000115 "The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." ; oboInOwl:hasDbXref "EMAPA:28212", "FMA:70498", "MA:0002584", "NCIT:C32826", "SCTID:76147008", "UMLS:C1512856", "Wikipedia:Interlobular_arteries" ; oboInOwl:hasExactSynonym "interlobular renal artery", "kidney interlobular artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriae corticales radiatae", "arteriae interlobulares renis", "cortical radial arteries", "interlobular", "renal interlobular artery" ; oboInOwl:id "UBERON:0004723" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "interlobular artery" ; rdfs:subClassOf obo:UBERON_0003644, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001552 ] ; owl:disjointWith obo:UBERON_0009885 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png"^^xsd:anyURI . obo:UBERON_0004724 obo:IAO_0000115 "The medial palpebral ligament (tendo oculi), about 4 mm. in length and 2 mm. in breadth, is attached to the frontal process of the maxilla in front of the lacrimal groove. Crossing the lacrimal sac, it divides into two parts, upper and lower, each attached to the medial end of the corresponding tarsus. As the ligament crosses the lacrimal sac, a strong aponeurotic is given off from its posterior surface; this expands over the sac, and is attached to the posterior lacrimal crest." ; oboInOwl:hasDbXref "EMAPA:37608", "MA:0001258", "NCIT:C52724", "SCTID:280578002", "UMLS:C0229251", "Wikipedia:Medial_palpebral_ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "l. palpebrale mediale" ; oboInOwl:id "UBERON:0004724" ; a owl:Class ; rdfs:label "medial palpebral ligament" ; rdfs:subClassOf obo:UBERON_0000211, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004772 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6f/Gray894.png"^^xsd:anyURI . obo:UBERON_0004727 obo:IAO_0000115 "A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP]." ; oboInOwl:hasBroadSynonym "cochlear component" ; oboInOwl:hasDbXref "BAMS:cVIIIn", "BM:VIIIN", "BTO:0003490", "EHDAA2:0002195", "EMAPA:17802", "FMA:53431", "GAID:723", "MA:0001110", "MBA:948", "MESH:D003056", "NCIT:C12697", "SCTID:280286001", "UMLS:C0009201", "VHOG:0001182", "Wikipedia:Cochlear_nerve", "neuronames:1406" ; oboInOwl:hasExactSynonym "auditory nerve", "cochlear root of acoustic nerve", "cochlear root of eighth cranial nerve", "vestibulocochlear VIII nerve cochlear component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus vestibulocochlearis", "vestibulocochlear nerve cochlear component" ; oboInOwl:id "UBERON:0004727" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "cochlear nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001648 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001720 ] ) ] . obo:UBERON_0004731 obo:IAO_0000115 "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." ; obo:IAO_0000116 "We take the definition of neuromere from Puelles et al, although the existence of mesomeres and prosomeres may not be widely accepted" ; obo:UBPROP_0000001 "A metameric segment of the central nervous system.[ZFA]" ; dcterms:contributor ; oboInOwl:creation_date "2009-06-18T09:00:04Z" ; oboInOwl:hasDbXref "NLX:147842", "TAO:0001328", "Wikipedia:Neuromere", "ZFA:0001328" ; oboInOwl:hasExactSynonym "neural tube metameric segment", "neural tube segment", "neuromere", "neuromeres" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural metamere", "neural segment" ; oboInOwl:id "UBERON:0004731" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neuromere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004732 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ] ) ] . obo:UBERON_0004732 obo:IAO_0000115 "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." ; obo:IAO_0000116 "revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neuromere" ; oboInOwl:id "UBERON:0004732" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "segmental subdivision of nervous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0004733 obo:IAO_0000115 "An organ subunit that is part of a hindbrain [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:61998" ; oboInOwl:hasExactSynonym "hindbrain segment", "segment of hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004733" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "segmental subdivision of hindbrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0004734 obo:IAO_0000115 "Organism at the gastrula stage." ; obo:UBPROP_0000012 "We explicitly merge the NCITA terms here" ; oboInOwl:hasAlternativeId "UBERON:0007012" ; oboInOwl:hasDbXref "BILA:0000060", "BTO:0001403", "FBbt:00005317", "FMA:293108", "GAID:1302", "MESH:D005775", "MIAA:0000179", "NCIT:C34057", "NCIT:C34058", "UMLS:C0017199", "UMLS:C1284022", "Wikipedia:Gastrula", "Wikipedia:Trilaminar_blastocyst" ; oboInOwl:hasExactSynonym "gastrula embryo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blastocystis trilaminaris", "tri-laminar disc", "tri-laminar disk", "trilaminar blastocyst", "trilaminar blastoderm", "trilaminar disc", "trilaminar disk", "trilaminar germ" ; oboInOwl:id "UBERON:0004734" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gastrula" ; rdfs:subClassOf obo:UBERON_0000922, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000307 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000109 ] ) ] . obo:UBERON_0004736 obo:IAO_0000115 "Glomerulus of the mature vertebrate kidney, or metanephros." ; oboInOwl:hasDbXref "VHOG:0001242" ; oboInOwl:hasExactSynonym "glomerulus of metanephros" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004736" ; a owl:Class ; rdfs:label "metanephric glomerulus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0004737 obo:IAO_0000115 "A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition]." ; oboInOwl:hasDbXref "VHOG:0000983" ; oboInOwl:hasExactSynonym "collecting duct of metanephros" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metanephric collecting tubule" ; oboInOwl:id "UBERON:0004737" ; a owl:Class ; rdfs:label "metanephric collecting duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0014706 ], _:genid137225, _:genid137227 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001232 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0004739 obo:IAO_0000115 "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." ; obo:IAO_0000232 "a glomus differs from a glomerulus in that each vascular glomus services several tubules" ; obo:UBPROP_0000001 "Paired highly vascularized portion of the pronephros. Left and right glomeruli are fused at the midline. Begins to function between 40 and 48hpf. Drummond, 2000.[TAO]" ; obo:UBPROP_0000003 "The teleost pronephros shares many essential features with the amphibian pronephros including its derivation from mesoderm associated with the coelom and the derivation of the glomerular blood supply from the medial dorsal aorta. However, unlike the pronephros of amphibians, which have an external glomus and tubules with nephrostomes open to the coelom, the mature teleost pronephros has no connection to the body cavity and instead functions as a closed system (reference 1); This variation in nephron types [with external glomeruli that open into the coelom and with internal glomeruli that do not connect with the coelom] and their pattern of distribution suggest an evolutionary sequence. Ancestral craniates probably had an external glomerulus and nephrostomes, as do the first few to develop in very primitive craniates. (...) The mechanism would become more efficient as the coelomic recess into which each glomerulus discharged became a part of the tubule, that is, grew around the glomerulus as a renal capsule. The glomerulus becomes internal. The nephrostomes were lost during subsequent evolution, leaving the type of renal tubule found in most vertebrates (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "GO treats glomus and pronephric glomerulus differently" ; oboInOwl:hasAlternativeId "UBERON:0004191" ; oboInOwl:hasDbXref "AAO:0011049", "SCTID:360548001", "TAO:0001557", "VHOG:0001237", "XAO:0000318", "ZFA:0001557" ; oboInOwl:hasExactSynonym "glomerulus of pronephros" ; oboInOwl:hasNarrowSynonym "glomus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpuscle", "glomera", "pronephric glomera", "pronephric glomeruli", "pronephric glomus" ; oboInOwl:id "UBERON:0004739" ; a owl:Class ; rdfs:label "pronephric glomerulus" ; rdfs:subClassOf _:genid137236 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:UBERON_0004742 obo:IAO_0000115 "The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified]." ; obo:UBPROP_0000001 "Dermal bone that is usually the anteriormost bone of the lower jaw, and that articulates with the angular, or anguloarticular bone, posteriorly, and carries part of the mandibular sensory canal and pore openings of the mandibular sensory canal on its lateral surface. The dentary is a paired bone.[TAO]", "Ossified element of intramembranous origin that invests the lateral margin of Meckel's cartilage thereby forming the lateral side of the mandible in anurans and salamanders (Duellman & Trueb, 1994:293). In caecilians, the dentary is part of a compound bone termed the pseudodentary.[AAO]", "The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians. In mammals the lower jaw consists entirely of the dentary bone. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, ZFA:0000191_and_Liem_KF, p.248][VHOG]" ; obo:UBPROP_0000002 "relationship loss: overlaps dentary-anguloarticular joint (TAO:0001749)[TAO]" ; obo:UBPROP_0000003 "Of all these bones [dentary, splenials, coronoids, angular, surangular and prearticular], only the dentary remains in the lower jaw of a mammal.[well established][VHOG]" ; obo:UBPROP_0000008 "In lobe-finned fishes and the early fossil tetrapods, the bone homologous to the mandible of mammals is merely the largest of several bones in the lower jaw. In such animals, it is referred to as the dentary bone, and forms the body of the outer surface of the jaw. It is bordered below by a number of splenial bones, while the angle of the jaw is formed by a lower angular bone and a suprangular bone just above it. The inner surface of the jaw is lined by a prearticular bone, while the articular bone forms the articulation with the skull proper. Finally a set of three narrow coronoid bones lie above the prearticular bone. As the name implies, the majority of the teeth are attached to the dentary, but there are commonly also teeth on the coronoid bones, and sometimes on the prearticular as well. This complex primitive pattern has, however, been simplified to various degrees in the great majority of vertebrates, as bones have either fused or vanished entirely. In teleosts, only the dentary, articular, and angular bones remain, while in living amphibians, the dentary is accompanied only by the prearticular, and, in salamanders, one of the coronoids. The lower jaw of reptiles has only a single coronoid and splenial, but retains all the other primitive bones except the prearticular." ; oboInOwl:hasDbXref "AAO:0000124", "EFO:0003508", "TAO:0000191", "VHOG:0001022", "ZFA:0000191", "http://palaeos.com/vertebrates/bones/dermal/images/Dentary1.gif" ; oboInOwl:hasExactSynonym "dentaries", "dentary bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dentale", "os dentale", "sur-angulaire" ; oboInOwl:id "UBERON:0004742" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "dentary" ; rdfs:subClassOf obo:UBERON_0008907, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0003278 ], _:genid137250, _:genid137252, _:genid137255, _:genid137257 . obo:UBERON_0004753 obo:IAO_0000115 "Skeletal element that consists of the scapula and the coracoid[VSAO, modified]." ; obo:IAO_0000116 "todo - decide whether to create separate classes for cartilage & ossified. Wikipedia considers this absent in Therians, but if considered as a grouping of scapula and coracoid then it would be present" ; obo:UBPROP_0000001 "Fused, ossified portions of the scapula, procoracoid, and coracoid.[AAO]", "Pectoral fin cartilage that consists of a paired cartilaginous plate of the embryonic primary pectoral girdle and from which the scapular and coracaoid bones ossify.[TAO]", "either a fusion of the scapula and coracoid (the two main bones of the shoulder girdle), or the scapula & coracoid considered as a single structural unit.[Palaeos]" ; obo:UBPROP_0000002 "relationship loss: part_of scapular area (AAO:0000935)[AAO]" ; obo:UBPROP_0000012 "ZFA defines as precursor to scapula and coracoid. Cartilage in TAO" ; oboInOwl:hasDbXref "AAO:0000781", "TAO:0001455", "VSAO:0005002", "Wikipedia:Scapulocoracoid", "ZFA:0001455" ; oboInOwl:hasExactSynonym "scapulocoracoideum" ; oboInOwl:hasNarrowSynonym "coraco-scapular cartilage", "scapulo-coracoid cartilage", "scapulocoracoid cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004753" ; a owl:Class ; rdfs:label "scapulocoracoid" ; rdfs:subClassOf obo:UBERON_0004765, _:genid137270 . obo:UBERON_0004755 obo:IAO_0000115 "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]." ; obo:UBPROP_0000001 "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]" ; oboInOwl:hasDbXref "EMAPA:37744", "MA:0003047", "SCTID:309311006", "VSAO:0000015", "XAO:0004038", "ZFA:0005619" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004755" ; a owl:Class ; rdfs:comment "Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from" ; rdfs:label "skeletal tissue" ; rdfs:subClassOf obo:UBERON_0002384, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004765 ], _:genid137284 . obo:UBERON_0004756 obo:IAO_0000115 "Dermis-derived entity that is made of skeletal tissue." ; oboInOwl:hasExactSynonym "dermal element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004756" ; a owl:Class ; rdfs:label "dermal skeletal element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004755 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:UBERON_0004760 obo:IAO_0000115 "A gland that is part of an anal canal [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27221", "EMAPA:27233", "EMAPA:27543", "FMA:15720", "FMA:15724", "NCIT:C32068", "SCTID:245448005", "UMLS:C0162322", "Wikipedia:Anal_gland" ; oboInOwl:hasExactSynonym "gland of anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anal gland", "anal sac", "gland of anus", "rectal gland" ; oboInOwl:id "UBERON:0004760" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim ; a owl:Class ; rdfs:label "gland of anal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0004761 obo:IAO_0000115 "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." ; obo:UBPROP_0000012 "in contrast to chondrocranium, this structure is entirely cartiliginous. In Chondricthyes this is the same as the neurocranium. FMA:76621 is an undefined fetal structure, so we assume the correct placement is here. Note that this is distinct from MA:0000317 which is the uberon:neurocranium (the part of the cranium that encloses the brain)" ; oboInOwl:hasDbXref "AAO:0000094", "AAO:0010153", "EHDAA:6031", "FMA:76621", "NCIT:C34121", "SCTID:155540009", "UMLS:C1516496", "Wikipedia:Chondrocranium", "XAO:0003059" ; oboInOwl:hasExactSynonym "cartilaginous chondocranium", "cartiligionous skeletal structure of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilaginous skull", "chondocranium", "embryonic chondocranium", "neurocranium" ; oboInOwl:id "UBERON:0004761" ; a owl:Class ; rdfs:label "cartilaginous neurocranium" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002418 ], _:genid137307 . obo:UBERON_0004763 obo:IAO_0000115 "Replacement bone tissue that forms within cartilage[VSAO, modified]." ; obo:UBPROP_0000012 "the distinction between endochondral bone and endochondral bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type" ; oboInOwl:hasDbXref "EMAPA:35304", "MA:0002836", "Wikipedia:Endochondral_ossification" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004763" ; oboInOwl:inSubset core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "endochondral bone tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002513 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0002418 ] ; owl:disjointWith obo:UBERON_0004764 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0001958 ] ) ] . obo:UBERON_0004764 obo:IAO_0000115 "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." ; obo:UBPROP_0000012 "note the distinction between intramembranous bone and intramembranous bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type (it is under bone tissue and connective tissue; there are no child classes)" ; oboInOwl:hasDbXref "MA:0002837", "Wikipedia:Intramembranous_ossification" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004764" ; a owl:Class ; rdfs:label "intramembranous bone tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002514 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0001957 ] ) ] . obo:UBERON_0004765 obo:IAO_0000115 "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." ; obo:UBPROP_0000001 "Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]", "Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]" ; oboInOwl:hasDbXref "AAO:0011129", "TAO:0001890", "VSAO:0000128", "XAO:0004012", "ZFA:0005494", "galen:SkeletalStructure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004765" ; oboInOwl:inSubset core:organ_slim, core:uberon_slim ; a owl:Class ; rdfs:label "skeletal element" ; rdfs:subClassOf obo:UBERON_0000062, _:genid137330 . obo:UBERON_0004766 obo:IAO_0000115 "A bone that is part of a cranium." ; obo:IAO_0000232 "here cranium = skull - mandible" ; oboInOwl:hasDbXref "SCTID:181792001" ; oboInOwl:hasExactSynonym "cranium bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004766" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cranial bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] . obo:UBERON_0004767 obo:IAO_0000115 "A tooth that is on the vomer." ; obo:UBPROP_0000001 "Tooth that is attached to the vomer.[TAO]" ; obo:UBPROP_0000002 "relationship type change: OBO_REL:part_of vomer (TAO:0000308) CHANGED TO: attaches_to vomer (UBERON:0002396)[TAO]" ; oboInOwl:hasDbXref "AAO:0000635", "TAO:0001631" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004767" ; a owl:Class ; rdfs:label "vomerine tooth" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0017615 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002396 ] ) ] . obo:UBERON_0004768 obo:IAO_0000115 "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular." ; obo:IAO_0000116 "Do not manually classify under here - bones are automatically classified" ; oboInOwl:hasExactSynonym "lower jaw bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004768" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "bone of lower jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003278 ], _:genid137354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0004769 obo:IAO_0000115 "Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified]." ; obo:UBPROP_0000001 "Subdivision of long bone which forms the part of the bone between the two epiphyses; together with other the subdivisions of long bone, it constitutes the long bone. Examples: diaphysis of humerus, diaphysis of femur[FMA].", "The main or mid section (shaft) of a long bone. It is made up of cortical bone and usually contains bone marrow and adipose tissue (fat)[WP][FMA:24013, Wikipedia:Diaphysis]." ; oboInOwl:hasDbXref "EMAPA:35504", "FMA:24013", "GAID:189", "MESH:D018483", "SCTID:361729006", "Wikipedia:Diaphysis" ; oboInOwl:hasExactSynonym "body of long bone", "long bone diaphysis", "shaft of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004769" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "diaphysis" ; rdfs:subClassOf obo:UBERON_0005055 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg"^^xsd:anyURI . obo:UBERON_0004770 obo:IAO_0000115 "Anatomical system that consists of all the joints of the body." ; oboInOwl:hasDbXref "EMAPA:35150", "FMA:23878", "MA:0003007", "SCTID:361827000", "VSAO:0000181" ; oboInOwl:hasExactSynonym "joint system", "set of all joints of body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of all joints", "set of joints of body" ; oboInOwl:id "UBERON:0004770" ; a owl:Class ; rdfs:label "articular system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002328 ; owl:someValuesFrom obo:GO_0040011 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ], _:genid137364 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034925 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0000982 ] ) ] . obo:UBERON_0004771 obo:IAO_0000115 "Opening/conduit between the nasal cavity and the nasopharynx[AAO] The choanae are separated by the vomer[WP]." ; obo:UBPROP_0000001 "One of the paired openings from the nasal cavities into the pharynx. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-6, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]", "Opening between the nasal cavity and the nasopharynx.[AAO]" ; obo:UBPROP_0000003 "The choana, a unique 'internal nostril' opening from the nasal sac into the roof of the mouth, is a key part of the tetrapod (land vertebrate) respiratory system. It was the first component of the tetrapod body plan to evolve, well before the origin of limbs, and is therefore crucial to our understanding of the beginning of the fish-tetrapod transition. (...) Here we present new material of Kenichthys, a 395-million-year-old fossil fish from China, that provides direct evidence for the origin of the choana and establishes its homology: it is indeed a displaced posterior external nostril that, during a brief transitional stage illustrated by Kenichthys, separated the maxilla from the premaxilla.[well established][VHOG]" ; obo:UBPROP_0000008 "Fish don't have choanae, instead they have two pairs of external nostrils", "In addition to tetrapods, the lungfish has internal nostrils too. In tetrapods the exhalant nostril (choana) empties into the buccal cavity." ; oboInOwl:hasBroadSynonym "choana", "internal naris" ; oboInOwl:hasDbXref "AAO:0000093", "EHDAA2:0000242", "EHDAA:7842", "EMAPA:17849", "FMA:53143", "MA:0001323", "SCTID:244507001", "VHOG:0000545", "Wikipedia:Posterior_nasal_apertures", "XAO:0000277" ; oboInOwl:hasExactSynonym "posterior nasal apperture" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "choanae", "nasopharyngeal naris", "posterior choana", "posterior naris" ; oboInOwl:id "UBERON:0004771" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior nasal aperture" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010425 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/87/Gray855.png"^^xsd:anyURI . obo:UBERON_0004772 obo:IAO_0000115 "The tarsi (tarsal plates) are two comparatively thick, elongated plates of dense connective tissue, about 2.5 cm. in length; one is found in each eyelid, and contributes to its form and support. They directly abut the lid margins." ; obo:UBPROP_0000008 "In most taxa (birds, mammals, lizards), the tarsal plate is described as a dense, fibrous connective tissue, possibly including cartilage, present within one or both of the upper and lower eyelids (Gau- thier et al., 1988; Rieppel, 2000). In humans, the tarsal plate of the upper eyelid is composed of collagens types I, III, and V, as well as glycosaminogly- cans (chondroitin sulphate 4 and 6), aggrecan, and cartilage oligomeric matrix proteins but lacks collagen type II as well as chondrocytes (Milz et al., 2005). Thus, for humans, the upper tarsal plate represents neither a truly fibrous nor a truly cartilagi- nous element but instead one that is composed of a unique transitional tissue (Milz et al., 2005). In many birds, lizards, and Sphenodon (the tuatara), the upper eyelid has lim- ited mobility and a putative tarsal plate is instead found within the lower eyelid (Underwood, 1970; Gau- thier et al., 1988)." ; oboInOwl:hasDbXref "FMA:59086", "MA:0000270", "NCIT:C33736", "SCTID:362529005", "UMLS:C0459586", "Wikipedia:Tarsus_(eyelids)" ; oboInOwl:hasExactSynonym "tarsal plate", "tarsal plate of eyelid", "tarsus palpebralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eyelid tarsi", "tarsi" ; oboInOwl:id "UBERON:0004772" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "eyelid tarsus" ; rdfs:subClassOf obo:UBERON_0000094, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_18085 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011823 ], _:genid137391, _:genid137393 . obo:UBERON_0004773 obo:IAO_0000115 "An eyelid tarsus that is part of a upper eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37607", "FMA:59087", "MA:0001260", "SCTID:368773004", "Wikipedia:Tarsus_(eyelids)" ; oboInOwl:hasExactSynonym "superior tarsal plate", "superior tarsus", "superior tarsus of eyelid", "tarsal plate of upper eyelid", "tarsus of upper eyelid", "tarsus superior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004773" ; a owl:Class ; rdfs:label "superior eyelid tarsus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004772 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0004774 obo:IAO_0000115 "An eyelid tarsus that is part of a lower eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37606", "FMA:59088", "MA:0001257", "SCTID:368774005" ; oboInOwl:hasExactSynonym "inferior tarsal plate", "inferior tarsus", "inferior tarsus of eyelid", "tarsal plate of lower eyelid", "tarsus inferior", "tarsus of lower eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004774" ; a owl:Class ; rdfs:label "inferior eyelid tarsus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004772 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0004777 obo:IAO_0000115 "A submucosa that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37578", "MA:0001822" ; oboInOwl:hasExactSynonym "apparatus respiratorius submucosa", "submucosa of apparatus respiratorius", "submucosa of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004777" ; a owl:Class ; rdfs:label "respiratory system submucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003570 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004778 obo:IAO_0000115 "A submucosa that is part of a larynx [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35474", "FMA:321584", "MA:0002728", "SCTID:361941005" ; oboInOwl:hasExactSynonym "submucosa of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laryngeal submucosa" ; oboInOwl:id "UBERON:0004778" ; a owl:Class ; rdfs:label "larynx submucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0004779 obo:IAO_0000115 "A lamina propria that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37576", "MA:0001821" ; oboInOwl:hasExactSynonym "apparatus respiratorius lamina propria", "apparatus respiratorius lamina propria mucosa", "lamina propria mucosa of apparatus respiratorius", "lamina propria mucosa of respiratory system", "lamina propria of apparatus respiratorius", "lamina propria of respiratory system", "respiratory system lamina propria mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004779" ; a owl:Class ; rdfs:label "respiratory system lamina propria" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003570 ], _:genid137447 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004780 obo:IAO_0000115 "A lamina propria that is part of a gastrointestinal system." ; oboInOwl:hasDbXref "MA:0001899", "NCIT:C49299", "UMLS:C1708197" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004780" ; a owl:Class ; rdfs:label "gastrointestinal system lamina propria" ; rdfs:subClassOf _:genid137462 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] . obo:UBERON_0004781 obo:IAO_0000115 "A lamina propria that is part of a gallbladder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35371", "FMA:278594", "MA:0001633", "NCIT:C49228", "UMLS:C1708175" ; oboInOwl:hasExactSynonym "gall bladder lamina propria", "gall bladder lamina propria mucosa", "gallbladder lamina propria mucosa", "lamina propria mucosa of gall bladder", "lamina propria mucosa of gallbladder", "lamina propria of gall bladder", "lamina propria of gallbladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary lamina propria" ; oboInOwl:id "UBERON:0004781" ; a owl:Class ; rdfs:label "gallbladder lamina propria" ; rdfs:subClassOf _:genid137470 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0004782 obo:IAO_0000115 "A serous membrane that is part of a digestive system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37592", "MA:0001522" ; oboInOwl:hasExactSynonym "digestive system serosa", "digestive system serous membrane", "gastrointestinal system serous membrane", "serosa of digestive system", "serosa of gastrointestinal system", "serous membrane of digestive system", "serous membrane of gastrointestinal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004782" ; a owl:Class ; rdfs:label "gastrointestinal system serosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] . obo:UBERON_0004783 obo:IAO_0000115 "A serous membrane that is part of a gallbladder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35372", "FMA:14659", "MA:0001634", "SCTID:362197006" ; oboInOwl:hasExactSynonym "gall bladder serosa", "gall bladder serous membrane", "gallbladder serous membrane", "serosa of gall bladder", "serosa of gallbladder", "serous coat of gallbladder", "serous membrane of gall bladder", "serous membrane of gallbladder", "tunica serosa (vesica biliaris)", "tunica serosa vesicae biliaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary serosa" ; oboInOwl:id "UBERON:0004783" ; a owl:Class ; rdfs:label "gallbladder serosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0004784 obo:IAO_0000115 "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:13884", "MA:0002791", "NCIT:C119295" ; oboInOwl:hasExactSynonym "anatomical wall of cardiac ventricle", "anatomical wall of heart ventricle", "anatomical wall of lower chamber of heart", "anatomical wall of ventricle of heart", "cardiac ventricle anatomical wall", "cardiac ventricle wall", "heart ventricle anatomical wall", "lower chamber of heart anatomical wall", "lower chamber of heart wall", "ventricle of heart anatomical wall", "ventricle of heart wall", "ventricular wall", "wall of cardiac ventricle", "wall of heart ventricle", "wall of lower chamber of heart", "wall of ventricle of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "wall of ventricle" ; oboInOwl:id "UBERON:0004784" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "heart ventricle wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0004785 obo:IAO_0000115 "The mucous membrane lining the respiratory tract." ; obo:IAO_0000116 "TODO - split respiratory tract mucosa from respiratory system mucosa" ; oboInOwl:hasDbXref "BTO:0000973", "EMAPA:18334", "EMAPA:37577", "FMA:302092", "GAID:304", "MA:0001827", "MESH:D020545" ; oboInOwl:hasExactSynonym "apparatus respiratorius mucosa", "apparatus respiratorius mucosa of organ", "apparatus respiratorius mucous membrane", "mucosa of apparatus respiratorius", "mucosa of organ of apparatus respiratorius", "mucosa of organ of respiratory system", "mucosa of respiratory system", "mucous membrane of apparatus respiratorius", "mucous membrane of respiratory system", "respiratory system mucosa of organ", "respiratory system mucous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laryngeal mucous membrane", "respiratory mucosa", "respiratory tract mucosa" ; oboInOwl:id "UBERON:0004785" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "respiratory system mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004786 obo:IAO_0000115 "A mucosa that is part of a gastrointestinal system." ; oboInOwl:hasDbXref "BTO:0000546", "BTO:0005568", "EMAPA:36591", "MA:0001521", "SCTID:410433007" ; oboInOwl:hasExactSynonym "digestive tract mucosa", "gut mucosa", "gut mucuous membrane", "mucosa of gut" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004786" ; a owl:Class ; rdfs:comment "The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468" ; rdfs:label "gastrointestinal system mucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ], _:genid137556, _:genid137558, _:genid137560, _:genid137562 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] . obo:UBERON_0004789 obo:IAO_0000115 "A mucous gland that is part of a larynx [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37631", "MA:0001767" ; oboInOwl:hasExactSynonym "mucous gland of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004789" ; a owl:Class ; rdfs:label "larynx mucous gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001824 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0004790 obo:IAO_0000115 "A mucous gland that is part of the skin." ; obo:IAO_0000116 "See comments for 'skin mucus'" ; oboInOwl:hasDbXref "EMAPA:35775", "MA:0000148" ; oboInOwl:hasExactSynonym "mucous gland of entire skin", "mucous gland of skin of body", "skin mucus gland", "skin of body mucous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004790" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "skin mucous gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000319 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] . obo:UBERON_0004791 obo:IAO_0000115 "The thymic connective tissue which extends into the parenchyma." ; oboInOwl:hasDbXref "MA:0002674", "NCIT:C33773", "UMLS:C1515431" ; oboInOwl:hasExactSynonym "thymic trabecula", "thymus gland trabecula", "thymus trabeculae", "trabecula of thymus", "trabecula of thymus gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004791" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thymus trabecula" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002370 ], _:genid137592 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0004792 obo:IAO_0000115 "A secretion that is part of a endocrine pancreas [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0002517", "NCIT:C33255", "UMLS:C1518866" ; oboInOwl:hasExactSynonym "endocrine pancreas secretion", "pancreatic endocrine secretion", "pars endocrina pancreatis secretion", "secretion of pars endocrina pancreatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004792" ; a owl:Class ; rdfs:label "secretion of endocrine pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000016 ] ) ] . obo:UBERON_0004793 obo:IAO_0000115 "A secretion that is part of a exocrine pancreas [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0002518", "NCIT:C33256", "UMLS:C1518867" ; oboInOwl:hasExactSynonym "exocrine pancreas secretion", "pancreatic exocrine secretion", "pars exocrina pancreatis secretion", "secretion of pars exocrina pancreatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004793" ; a owl:Class ; rdfs:label "secretion of exocrine pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:UBERON_0004794 obo:IAO_0000115 "A secretion that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:79662", "MA:0002514", "NCIT:C52555", "UMLS:C0227179" ; oboInOwl:hasExactSynonym "esophageal secretion", "gullet secretion", "oesophagus secretion", "secretion of esophagus", "secretion of gullet", "secretion of oesophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004794" ; a owl:Class ; rdfs:label "esophagus secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0004795 obo:IAO_0000115 "A secretion that is part of a pancreas [Automatically generated definition]." ; oboInOwl:hasDbXref "MA:0002516", "NCIT:C13270", "UMLS:C0030296" ; oboInOwl:hasExactSynonym "pancreatic secretion", "secretion of pancreas" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004795" ; a owl:Class ; rdfs:label "pancreas secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0004796 obo:IAO_0000115 "A bodily secretion that is produced by the prostate gland." ; obo:UBPROP_0000008 "Prostatic secretions vary among species. They are generally composed of simple sugars and are often slightly alkaline." ; obo:UBPROP_0000010 "A secretion of the prostate this is slightly alkaline fluid, milky or white in appearance. Usually constitutes 20-30% of the volume of the semen along with spermatozoa and seminal vesicle fluid [Wikipedia:Prostate#Secretions]" ; oboInOwl:hasAlternativeId "UBERON:0010142" ; oboInOwl:hasDbXref "EMAPA:36545", "FMA:66884", "MA:0002525", "NCIT:C52553", "UMLS:C1709733", "Wikipedia:Prostate#Secretions" ; oboInOwl:hasExactSynonym "prostate secretion", "prostatic fluid", "secretion of prostate", "secretion of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prostate fluid" ; oboInOwl:id "UBERON:0004796" ; a owl:Class ; rdfs:label "prostate gland secretion" ; rdfs:subClassOf obo:UBERON_0006530 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0004797 obo:IAO_0000115 "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." ; oboInOwl:hasDbXref "EMAPA:36296", "MA:0002854" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004797" ; a owl:Class ; rdfs:label "blood vessel layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035965 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg"^^xsd:anyURI . obo:UBERON_0004801 obo:IAO_0000115 "An epithelium that is part of a uterine cervix [Automatically generated definition]." ; obo:UBPROP_0000010 "The epithelium of the cervix is varied. The ectocervix (more distal, by the vagina) is composed of nonkeratinized stratified squamous epithelium. The endocervix (more proximal, within the uterus) is composed of simple columnar epithelium" ; oboInOwl:hasDbXref "BTO:0000241", "CALOHA:TS-0137", "EFO:0001913", "EMAPA:29929", "MA:0001724", "NCIT:C49218", "UMLS:C1711358" ; oboInOwl:hasExactSynonym "cervical canal epithelial tissue", "cervical canal epithelium", "cervical epithelium", "cervix epithelial tissue", "epithelium of cervix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004801" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "cervix epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000002 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0004802 obo:IAO_0000115 "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." ; oboInOwl:hasDbXref "BTO:0000419", "CALOHA:TS-0023", "EMAPA:32827", "MA:0001480", "SCTID:321764001", "VHOG:0000981" ; oboInOwl:hasExactSynonym "epithelial tissue of respiratory tract", "epithelium of respiratory tract", "respiratory tract epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "airway epithelium", "respiratory epithelium" ; oboInOwl:id "UBERON:0004802" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "respiratory tract epithelium" ; rdfs:subClassOf obo:UBERON_0010499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:UBERON_0004803 obo:IAO_0000115 "An epithelium that is part of a penis [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0004039", "EMAPA:35674", "MA:0001742" ; oboInOwl:hasExactSynonym "epithelial tissue of penis", "epithelium of penis", "penis epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004803" ; a owl:Class ; rdfs:label "penis epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0004804 obo:IAO_0000115 "An epithelium that is part of a oviduct [Automatically generated definition]." ; obo:UBPROP_0000012 "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" ; oboInOwl:hasDbXref "BTO:0002402", "CALOHA:TS-1316", "EMAPA:29043", "MA:0001718" ; oboInOwl:hasExactSynonym "epithelial tissue of oviduct", "epithelium of fallopian tube", "epithelium of oviduct", "epithelium of uterine tube", "oviduct epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columnar epithelium of the fallopian tube", "columnar epithelium of the oviduct", "fallopian tube epithelium" ; oboInOwl:id "UBERON:0004804" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "oviduct epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:UBERON_0004805 obo:IAO_0000115 "An epithelium that is part of a seminal vesicle [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-2069", "EMAPA:29771", "MA:0001745", "NCIT:C49295", "UMLS:C1710049" ; oboInOwl:hasExactSynonym "epithelial tissue of seminal gland", "epithelial tissue of seminal vesicle", "epithelium of seminal gland", "epithelium of seminal vesicle", "seminal gland epithelial tissue", "seminal gland epithelium", "seminal vesicle epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004805" ; a owl:Class ; rdfs:label "seminal vesicle epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:UBERON_0004806 obo:IAO_0000115 "An epithelium that is part of a vas deferens [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:29274", "FMA:225317", "MA:0001749", "NCIT:C49315", "UMLS:C1710617" ; oboInOwl:hasExactSynonym "deferent duct epithelial tissue", "deferent duct epithelium", "ductus deferens epithelial tissue", "ductus deferens epithelium", "epithelial tissue of deferent duct", "epithelial tissue of ductus deferens", "epithelial tissue of sperm duct", "epithelial tissue of vas deferen", "epithelial tissue of vas deferens", "epithelium of deferent duct", "epithelium of ductus deferens", "epithelium of sperm duct", "epithelium of vas deferen", "epithelium of vas deferens", "sperm duct epithelial tissue", "sperm duct epithelium", "vas deferen epithelial tissue", "vas deferen epithelium", "vas deferens epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004806" ; a owl:Class ; rdfs:label "vas deferens epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ] . obo:UBERON_0004807 obo:IAO_0000115 "An epithelium that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-0023", "EMAPA:32826", "MA:0001823", "VHOG:0000981" ; oboInOwl:hasExactSynonym "apparatus respiratorius epithelial tissue", "apparatus respiratorius epithelium", "epithelial tissue of apparatus respiratorius", "epithelial tissue of respiratory system", "epithelium of apparatus respiratorius", "epithelium of respiratory system", "respiratory system epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004807" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "respiratory system epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004808 obo:IAO_0000115 "An epithelium that is part of a digestive system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32683", "MA:0001520" ; oboInOwl:hasExactSynonym "digestive system epithelial tissue", "digestive system epithelium", "epithelial tissue of digestive system", "epithelial tissue of gastrointestinal system", "epithelium of digestive system", "epithelium of gastrointestinal system", "gastrointestinal system epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004808" ; a owl:Class ; rdfs:label "gastrointestinal system epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] . obo:UBERON_0004809 obo:IAO_0000115 "An epithelium that is part of a salivary gland [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004421", "CALOHA:TS-2067", "EMAPA:32816", "MA:0001587" ; oboInOwl:hasExactSynonym "epithelial tissue of salivary gland", "epithelium of salivary gland", "salivary gland epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004809" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "salivary gland epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0004810 obo:IAO_0000115 "The cellular avascular layer of the renal tubule luminar surfaces." ; obo:IAO_0000116 "See https://github.com/obophenotype/uberon/issues/1305" ; oboInOwl:hasDbXref "BTO:0005239", "EMAPA:36524", "MA:0001681", "NCIT:C49276", "UMLS:C1709902" ; oboInOwl:hasExactSynonym "kidney tubule epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004810" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nephron tubule epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001231 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004819 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000464 ] ) ] . obo:UBERON_0004811 obo:IAO_0000115 "An epithelium that is part of an endometrium [Automatically generated definition]." ; obo:UBPROP_0000008 "In rodents and primates, the uterine epithelium (the endometrium) is eroded away so that maternal blood comes into direct contact with the trophoblast surface (called haemochorial)" ; oboInOwl:hasDbXref "EMAPA:35307", "MA:0002731", "SCTID:253526009" ; oboInOwl:hasExactSynonym "endometrium epithelial tissue", "epithelial tissue of endometrium", "epithelium of endometrium", "epithelium of tunica mucosa of endometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "uterine epithelium" ; oboInOwl:id "UBERON:0004811" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "endometrium epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ] . obo:UBERON_0004812 obo:IAO_0000115 "An epithelium that is part of a prepuce of penis [Automatically generated definition]." ; obo:IAO_0000116 "NCITA term may be sex-neutral" ; oboInOwl:hasBroadSynonym "epithelial tissue of prepuce", "epithelium of prepuce", "prepuce epithelial tissue", "prepuce of penis epithelium" ; oboInOwl:hasDbXref "EMAPA:30655", "MA:0001753", "NCIT:C49270", "UMLS:C1709639" ; oboInOwl:hasExactSynonym "epithelial tissue of foreskin", "epithelial tissue of penile prepuce", "epithelial tissue of prepuce of penis", "epithelium of foreskin", "epithelium of penile prepuce", "epithelium of prepuce of penis", "foreskin epithelial tissue", "foreskin epithelium", "penile prepuce epithelial tissue", "penile prepuce epithelium", "prepuce epithelium", "prepuce of penis epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004812" ; a owl:Class ; rdfs:label "male prepuce epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001332 ] ) ] . obo:UBERON_0004813 obo:IAO_0000115 "The stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule." ; oboInOwl:hasDbXref "BTO:0001811", "CALOHA:TS-0920", "EHDAA:8148", "EMAPA:35761", "FMA:19885", "GAID:401", "MA:0001748", "MESH:D012670", "NCIT:C49296", "RETIRED_EHDAA2:0002009", "UMLS:C0036629", "VHOG:0000631", "Wikipedia:Germinal_epithelium_(male)" ; oboInOwl:hasExactSynonym "epithelial tissue of seminiferous tubule", "epithelial tissue of seminiferous tubule of testis", "epithelium of seminiferous tubule", "epithelium of seminiferous tubule of testis", "germinal epithelium (male)", "male germinal epithelium", "seminiferous epithelium", "seminiferous tubule epithelial tissue", "testis germinal epithelium", "wall of seminiferous tubule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004813" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "seminiferous tubule epithelium" ; rdfs:subClassOf obo:UBERON_0001136, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000020 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000216 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001343 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001343 ] ) ] . obo:UBERON_0004814 obo:IAO_0000115 "An epithelium that is part of a upper respiratory tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35894", "MA:0001912" ; oboInOwl:hasExactSynonym "epithelial tissue of upper respiratory tract", "epithelium of upper respiratory tract", "upper respiratory tract epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004814" ; a owl:Class ; rdfs:label "upper respiratory tract epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 ] ) ] . obo:UBERON_0004815 obo:IAO_0000115 "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37549", "MA:0001481" ; oboInOwl:hasExactSynonym "epithelial tissue of lower respiratory tract", "epithelium of lower respiratory tract", "lower respiratory tract epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004815" ; a owl:Class ; rdfs:label "lower respiratory tract epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ] ) ] . obo:UBERON_0004816 obo:IAO_0000115 "An epithelium that is part of a larynx [Automatically generated definition]." ; obo:UBPROP_0000010 "composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx [ISBN:0-397-51047-0]" ; oboInOwl:hasDbXref "EHDAA2:0004065", "EMAPA:35472", "MA:0001765", "NCIT:C49247", "UMLS:C0751258" ; oboInOwl:hasExactSynonym "epithelial tissue of larynx", "epithelium of larynx", "laryngeal epithelium", "larynx epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004816" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "larynx epithelium" ; rdfs:subClassOf _:genid136602 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0004817 obo:IAO_0000115 "An epithelium that is part of a lacrimal gland [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36515", "MA:0001297" ; oboInOwl:hasExactSynonym "epithelial tissue of lacrimal gland", "epithelium of lacrimal gland", "lacrimal gland epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004817" ; a owl:Class ; rdfs:label "lacrimal gland epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001817 ] ) ] . obo:UBERON_0004819 obo:IAO_0000115 "The cellular avascular layer of the kidney luminar surfaces." ; oboInOwl:hasDbXref "BTO:0000059", "CALOHA:TS-0505", "EMAPA:35457", "MA:0002846" ; oboInOwl:hasExactSynonym "epithelial tissue of kidney", "epithelium of kidney", "kidney epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renal epithelium" ; oboInOwl:id "UBERON:0004819" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney epithelium" ; rdfs:subClassOf _:genid136621 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0004820 obo:IAO_0000115 "Any epithelium that lines one of the bile ducts." ; obo:UBPROP_0000001 "The irregularly shaped proliferating bile ducts are lined by normal cuboidal epithelium." ; oboInOwl:hasDbXref "BTO:0000417", "MA:0001629", "NCIT:C43616", "UMLS:C1711208" ; oboInOwl:hasExactSynonym "biliary duct epithelium", "epithelium of bile duct", "epithelium of biliary duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004820" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bile duct epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000488 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002394 ] ) ] . obo:UBERON_0004821 obo:IAO_0000115 "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." ; oboInOwl:hasDbXref "BTO:0003511", "EMAPA:35121", "FMA:63915", "MA:0001771", "NCIT:C12867" ; oboInOwl:hasExactSynonym "alveolus epithelial tissue", "alveolus epithelium", "epithelial tissue of alveolus", "epithelium of alveolus", "epithelium of pulmonary alveolus", "pulmonary alveolar epithelium", "pulmonary alveolus epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alveolar epithelium" ; oboInOwl:id "UBERON:0004821" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary alveolus epithelium" ; rdfs:subClassOf obo:UBERON_0000487, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000115 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002299 ], _:genid137903, _:genid137905 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:UBERON_0004822 obo:IAO_0000115 "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000742", "EHDAA:3051", "MA:0002661", "NCIT:C43618", "UMLS:C1711347" ; oboInOwl:hasExactSynonym "epithelial tissue of extrahepatic bile duct", "epithelium of extrahepatic bile duct", "extrahepatic bile duct epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004822" ; a owl:Class ; rdfs:label "extrahepatic bile duct epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 _:genid136658 ) ] . obo:UBERON_0004823 obo:IAO_0000115 "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000743", "EHDAA:3053", "MA:0002662", "NCIT:C43617", "UMLS:C1708552" ; oboInOwl:hasExactSynonym "epithelial tissue of intrahepatic bile duct", "epithelium of intrahepatic bile duct", "intrahepatic bile duct epithelial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004823" ; a owl:Class ; rdfs:label "intrahepatic bile duct epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 _:genid136667 ) ] . obo:UBERON_0004827 obo:IAO_0000115 "A medulla that is part of a thyroid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37768", "MA:0000132" ; oboInOwl:hasExactSynonym "medulla of thyroid", "medulla of thyroid follicle", "medulla of thyroid gland", "medulla of thyroid gland follicle", "thyroid follicle medulla", "thyroid gland follicle medulla", "thyroid medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004827" ; a owl:Class ; rdfs:label "thyroid gland medulla" ; owl:equivalentClass _:genid136674 . obo:UBERON_0004829 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37788", "MA:0001690" ; oboInOwl:hasExactSynonym "skeletal muscle of urethra", "skeletal muscle tissue of urethra", "urethra skeletal muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urethra skeletal muscle", "urethral skeletal muscle" ; oboInOwl:id "UBERON:0004829" ; a owl:Class ; rdfs:label "urethra skeletal muscle tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003829 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0004830 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37583", "MA:0001829" ; oboInOwl:hasExactSynonym "respiratory system skeletal muscle tissue", "skeletal muscle of apparatus respiratorius", "skeletal muscle of respiratory system", "skeletal muscle tissue of apparatus respiratorius", "skeletal muscle tissue of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004830" ; a owl:Class ; rdfs:label "respiratory system skeletal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004831 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36523", "MA:0001572" ; oboInOwl:hasExactSynonym "esophagus skeletal muscle tissue", "skeletal muscle of esophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004831" ; a owl:Class ; rdfs:comment "Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal" ; rdfs:label "esophagus skeletal muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003832 ] ; owl:equivalentClass _:genid136710 . obo:UBERON_0004832 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37393", "MA:0001530" ; oboInOwl:hasExactSynonym "anal part of perineum skeletal muscle", "anal part of perineum skeletal muscle tissue", "anal region skeletal muscle tissue", "anal triangle skeletal muscle", "anal triangle skeletal muscle tissue", "skeletal muscle of anal part of perineum", "skeletal muscle of anal region", "skeletal muscle of anal triangle", "skeletal muscle tissue of anal part of perineum", "skeletal muscle tissue of anal region", "skeletal muscle tissue of anal triangle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004832" ; a owl:Class ; rdfs:label "anal region skeletal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] ) ] . obo:UBERON_0004833 obo:IAO_0000115 "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." ; obo:IAO_0000116 "this class is derived from MA. Consider re-modeling this as being a muscle that acts on the lips. See: Wikipedia:Lip#Muscles_acting_on_the_lips" ; oboInOwl:hasDbXref "EMAPA:37642", "MA:0001578" ; oboInOwl:hasExactSynonym "lip skeletal muscle tissue", "skeletal muscle of lip", "skeletal muscle tissue of lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004833" ; a owl:Class ; rdfs:label "lip skeletal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0004834 obo:IAO_0000115 "Smooth muscle tissue in all or part of a hepatic duct." ; oboInOwl:hasDbXref "EMAPA:37598", "MA:0001640" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004834" ; a owl:Class ; rdfs:label "hepatic duct smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid136745 ] . obo:UBERON_0004835 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:30747", "MA:0001736" ; oboInOwl:hasExactSynonym "epididymis involuntary muscle", "epididymis non-striated muscle", "epididymis smooth muscle tissue", "involuntary muscle of epididymis", "non-striated muscle of epididymis", "smooth muscle of epididymis", "smooth muscle tissue of epididymis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004835" ; a owl:Class ; rdfs:label "epididymis smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:UBERON_0004848 obo:IAO_0000115 "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37566", "MA:0001801" ; oboInOwl:hasExactSynonym "apparatus respiratorius arterial endothelium", "apparatus respiratorius artery endothelium", "apparatus respiratorius endothelium of artery", "arterial endothelium of apparatus respiratorius", "arterial endothelium of respiratory system", "artery endothelium of apparatus respiratorius", "artery endothelium of respiratory system", "endothelium of artery of apparatus respiratorius", "endothelium of artery of respiratory system", "respiratory system artery endothelium", "respiratory system endothelium of artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004848" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory system arterial endothelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003643 ], _:genid138028, _:genid138030 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001917 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004849 obo:IAO_0000115 "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37585", "MA:0001811" ; oboInOwl:hasExactSynonym "apparatus respiratorius endothelium of vein", "apparatus respiratorius vein endothelium", "apparatus respiratorius venous endothelium", "endothelium of vein of apparatus respiratorius", "endothelium of vein of respiratory system", "respiratory system endothelium of vein", "respiratory system vein endothelium", "vein endothelium of apparatus respiratorius", "vein endothelium of respiratory system", "venous endothelium of apparatus respiratorius", "venous endothelium of respiratory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004849" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory system venous endothelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003476 ], _:genid138051 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001919 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0004850 obo:IAO_0000115 "An endothelium that is part of a lymph node [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35526", "MA:0000741" ; oboInOwl:hasExactSynonym "endothelium of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004850" ; a owl:Class ; rdfs:label "lymph node endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_0004851 obo:IAO_0000115 "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." ; oboInOwl:hasDbXref "BTO:0000394", "CALOHA:TS-0047", "EFO:0002597", "EMAPA:35134", "MA:0000701", "NCIT:C49190", "UMLS:C1706824" ; oboInOwl:hasExactSynonym "adult aorta endothelium", "endothelium of adult aorta", "endothelium of aorta", "endothelium of trunk of aortic tree", "endothelium of trunk of systemic arterial tree", "trunk of aortic tree endothelium", "trunk of systemic arterial tree endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aortic endothelium" ; oboInOwl:id "UBERON:0004851" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "aorta endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0004852 obo:IAO_0000115 "An endothelium that is part of the cardiovascular system." ; obo:IAO_0000116 "consider merging with 'endothelium'" ; obo:UBPROP_0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001853", "EMAPA:35201", "GAID:519", "MA:0000717", "MESH:D004730", "NCIT:C13053", "TAO:0002171", "UMLS:C0014261", "VHOG:0001217", "XAO:0000356", "ZFA:0001639" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "endothelia", "vascular endothelia" ; oboInOwl:id "UBERON:0004852" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "cardiovascular system endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 ] ) ] . obo:UBERON_0004854 obo:IAO_0000115 "A mesentery that is part of a digestive system [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37068", "MA:0001900" ; oboInOwl:hasExactSynonym "digestive system mesentery", "mesentery of digestive system", "mesentery of gastrointestinal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004854" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gastrointestinal system mesentery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ] . obo:UBERON_0004857 obo:IAO_0000115 "A connective tissue that surrounds a skeletal muscle tissue." ; oboInOwl:hasDbXref "EMAPA:37743", "MA:0002868" ; oboInOwl:hasExactSynonym "connective tissue of skeletal muscle", "connective tissue of skeletal muscle tissue", "portion of connective tissue of skeletal muscle", "portion of connective tissue of skeletal muscle tissue", "skeletal muscle portion of connective tissue", "skeletal muscle textus connectivus", "skeletal muscle tissue connective tissue", "skeletal muscle tissue portion of connective tissue", "skeletal muscle tissue textus connectivus", "textus connectivus of skeletal muscle", "textus connectivus of skeletal muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal muscle interstitial tissue", "skeletal muscle interstitum" ; oboInOwl:id "UBERON:0004857" ; a owl:Class ; rdfs:label "skeletal muscle connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:UBERON_0004859 obo:IAO_0000115 "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." ; oboInOwl:hasDbXref "EMAPA:35334", "MA:0000267" ; oboInOwl:hasExactSynonym "eye-associated gland", "gland of eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004859" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:comment "Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands" ; rdfs:label "eye gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] . obo:UBERON_0004861 obo:IAO_0000115 "An alveolus that is part of a right lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35997", "MA:0001786", "NCIT:C49278", "UMLS:C1709959" ; oboInOwl:hasExactSynonym "alveolus of right lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004861" ; a owl:Class ; rdfs:label "right lung alveolus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006526 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0004862 obo:IAO_0000115 "An alveolus that is part of a left lung [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:19182", "MA:0001777", "NCIT:C49251", "UMLS:C1708673" ; oboInOwl:hasExactSynonym "alveolus of left lung", "alveolus of lobe of left lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004862" ; a owl:Class ; rdfs:label "left lung alveolus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006525 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0004863 obo:IAO_0000115 "A sympathetic nerve trunk that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37657", "FMA:6262", "MA:0001165", "NCIT:C52827", "UMLS:C1710393" ; oboInOwl:hasExactSynonym "nerve trunk of sympathetic nervous system of thorax", "nerve trunk of sympathetic part of autonomic division of nervous system of thorax", "sympathetic nerve trunk of thorax", "sympathetic nervous system nerve trunk of thorax", "thoracic part of sympathetic trunk", "thoracic sympathetic chain", "thorax nerve trunk of sympathetic nervous system", "thorax nerve trunk of sympathetic part of autonomic division of nervous system", "thorax sympathetic nerve trunk", "thorax sympathetic nervous system nerve trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thoracic sympathetic trunk" ; oboInOwl:id "UBERON:0004863" ; a owl:Class ; rdfs:label "thoracic sympathetic nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0004864 obo:IAO_0000115 "A vasculature that is part of a retina [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:76552", "MESH:D012171", "XAO:0004153" ; oboInOwl:hasExactSynonym "retina vasculature", "retina vasculature of camera-type eye", "retinal blood vessels", "retinal blood vessels set", "retinal vasculature", "set of blood vessels of retina", "set of retinal blood vessels", "vasa sanguinea retinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004864" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "vasculature of retina" ; rdfs:subClassOf obo:UBERON_0036302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000966 ] ) ] . obo:UBERON_0004867 obo:IAO_0000115 "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye." ; obo:UBPROP_0000012 "note that the AAO and ZFA class is a cavity" ; oboInOwl:hasDbXref "AAO:0000343", "FMA:84961", "SCTID:280541000", "Wikipedia:Orbit_(anatomy)", "ZFA:0005558" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "orbit" ; oboInOwl:id "UBERON:0004867" ; a owl:Class ; rdfs:label "orbital cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001697 ] ) ] . obo:UBERON_0004869 obo:IAO_0000115 "A part of the epithalamus present in some animal species. The eye may be photoreceptive and is usually associated with the pineal gland, regulating circadian rhythmicity and hormone production for thermoregulation. The parietal eye is a part of the epithalamus, which can be divided into two major parts; the epiphysis (the pineal organ, or pineal gland if mostly endocrine) and the parietal organ (often called the parietal eye, or third eye if it is photoreceptive). It arises as an anterior evagination of the pineal organ or as a separate outgrowth of the roof of the diencephalon. In some species, it protrudes through the skull.[4] The parietal eye uses a different biochemical method of detecting light than rod cells or cone cells in a normal vertebrate eye[WP]." ; oboInOwl:hasDbXref "Wikipedia:Parietal_eye" ; oboInOwl:hasExactSynonym "parietal eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "third eye" ; oboInOwl:id "UBERON:0004869" ; a owl:Class ; rdfs:label "parietal organ" ; rdfs:subClassOf obo:UBERON_0003103, _:genid138186 . obo:UBERON_0004871 obo:IAO_0000115 "Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP]." ; obo:IAO_0000116 "check BILA" ; oboInOwl:hasDbXref "AAO:0011100", "BILA:0000047", "FMA:295570", "Wikipedia:Lateral_plate_mesoderm#Division_into_layers", "XAO:0000271" ; oboInOwl:hasExactSynonym "outer layer of lateral plate mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parietal mesoderm", "somatic mesoderm" ; oboInOwl:id "UBERON:0004871" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "somatic layer of lateral plate mesoderm" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 ] . obo:UBERON_0004872 obo:IAO_0000115 "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." ; obo:UBPROP_0000012 "We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors" ; oboInOwl:hasBroadSynonym "visceral mesoderm" ; oboInOwl:hasDbXref "AAO:0011102", "BILA:0000044", "FMA:295568", "Wikipedia:Lateral_plate_mesoderm#Division_into_layers", "XAO:0000276" ; oboInOwl:hasExactSynonym "inner layer of lateral plate mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "splanchnic mesoderm" ; oboInOwl:id "UBERON:0004872" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "splanchnic layer of lateral plate mesoderm" ; rdfs:subClassOf obo:UBERON_0005423, _:genid136930, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 ] . obo:UBERON_0004873 obo:IAO_0000115 "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]." ; obo:IAO_0000116 "TODO - check relationship to LPM" ; oboInOwl:hasDbXref "EHDAA2:0001903", "EHDAA:383", "EMAPA:16181", "FMA:295564", "NCIT:C34303", "UMLS:C1519472", "VHOG:0000558", "Wikipedia:Splanchnopleure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventral splanchnic mesoderm" ; oboInOwl:id "UBERON:0004873" ; a owl:Class ; rdfs:label "splanchnopleure" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000925 ], _:genid138203 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png"^^xsd:anyURI . obo:UBERON_0004874 obo:IAO_0000115 "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." ; obo:UBPROP_0000011 "Gives rise to the paired appendages in jawed vertebrates. a persistent somatopleure through the redistribution and expansion of the lateral plate mesoderm is a synapomorphy for gnathostomes and a critical step in generating a novel developmental module with dramatic evolutionary potentia (Tulenko et al. 2012) http://burkelab.research.wesleyan.edu/current-projects/lamprey/" ; obo:UBPROP_0000012 "sources differ as to whether this is part-of or develops-from the LPM" ; oboInOwl:hasDbXref "EHDAA2:0001847", "EHDAA:381", "EMAPA:16180", "FMA:295566", "NCIT:C34301", "UMLS:C1519423", "VHOG:0000557", "Wikipedia:Somatopleure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004874" ; a owl:Class ; rdfs:label "somatopleure" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000924 ], _:genid138210 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png"^^xsd:anyURI . obo:UBERON_0004875 obo:IAO_0000115 "A portion of the urogenital ridge which is the source of much of the urinary system[WP]." ; oboInOwl:hasDbXref "FMA:72168", "NCIT:C34219", "SCTID:361405003", "UMLS:C1283944", "Wikipedia:Nephrogenic_cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chorda nephrogenica" ; oboInOwl:id "UBERON:0004875" ; a owl:Class ; rdfs:comment "part_of or develops_from urogenital ridge?" ; rdfs:label "nephrogenic cord" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004876 ] . obo:UBERON_0004876 obo:IAO_0000115 "One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]." ; obo:UBPROP_0000013 "Less commonly, urogenital fold refers to the fold in the mesonephros which is the precursor of e.g. the suspensory ligament of the ovary. This is the case in older versions of Gray's anatomy[WP]" ; oboInOwl:hasDbXref "EHDAA2:0004022", "EMAPA:30888", "FMA:321919", "Wikipedia:Urogenital_folds" ; oboInOwl:hasExactSynonym "urethral fold", "urogenital fold" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urogenital ridge" ; oboInOwl:id "UBERON:0004876" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "urogenital fold" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0004176 ], _:genid138221, _:genid138223, _:genid138225 . obo:UBERON_0004880 obo:IAO_0000115 "The central region of trunk mesoderm. This tissue forms the notochord." ; obo:UBPROP_0000001 "Notochord rudiment[ZFIN:ZDB-PUB-961014-576]." ; obo:UBPROP_0000012 "WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord." ; oboInOwl:hasDbXref "AAO:0000478", "EFO:0003426", "TAO:0000091", "ZFA:0000091" ; oboInOwl:hasExactSynonym "axial chorda mesoderm", "chorda mesoderm", "dorsal mesoderm", "presumptive notochord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004880" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "chordamesoderm" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003068 ] . obo:UBERON_0004883 obo:IAO_0000115 "The mass of tissue made up of mesenchymal cells in the lung." ; oboInOwl:hasDbXref "EMAPA:32866" ; oboInOwl:hasExactSynonym "lung-associated mesenchyme", "mesenchyme of lung", "pulmonary mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004883" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lung mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0004893 obo:IAO_0000115 "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung." ; oboInOwl:hasDbXref "BTO:0003149", "EMAPA:35433", "MA:0000421", "NCIT:C49473", "UMLS:C1706784", "Wikipedia:Alveolar_septum" ; oboInOwl:hasExactSynonym "alveolar septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "septum interalveolare" ; oboInOwl:id "UBERON:0004893" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interalveolar septum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006524 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003037 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:UBERON_0004894 obo:IAO_0000115 "A wall that contains the alveoli." ; obo:UBPROP_0000012 "part of wall in FMA" ; oboInOwl:hasAlternativeId "UBERON:0008872" ; oboInOwl:hasDbXref "BTO:0002543", "EMAPA:35120", "FMA:14117", "MA:0002568", "NCIT:C13085", "SCTID:361965008", "UMLS:C0225695" ; oboInOwl:hasExactSynonym "pulmonary alveolar wall", "pulmonary interalveolar septum", "wall of pulmonary alveolus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alveolus wall" ; oboInOwl:id "UBERON:0004894" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "alveolar wall" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002299 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:UBERON_0004895 obo:IAO_0000115 "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus." ; oboInOwl:hasDbXref "EMAPA:35122", "MA:0002759" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004895" ; a owl:Class ; rdfs:label "alveolar smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:UBERON_0004902 obo:IAO_0000115 "The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra." ; obo:UBPROP_0000012 "we follow EHDAA2 in dividing the UGS into epithelium and lumen" ; oboInOwl:hasDbXref "EHDAA2:0004061", "EMAPA:31509" ; oboInOwl:hasExactSynonym "UGE", "epithelium of urogenital sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004902" ; a owl:Class ; rdfs:label "urogenital sinus epithelium" ; rdfs:subClassOf obo:UBERON_0000483, _:genid138279 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000164 ] ) ] . obo:UBERON_0004904 obo:IAO_0000115 "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." ; oboInOwl:hasBroadSynonym "optic nerve" ; oboInOwl:hasDbXref "BTO:0000966", "EV:0100351", "FBbt:00001956", "TADS:0000232" ; oboInOwl:hasExactSynonym "optic nerve (generic)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004904" ; oboInOwl:inSubset core:grouping_class, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II)" ; rdfs:label "neuron projection bundle connecting eye with brain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000122 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0005388 ] ) ] . obo:UBERON_0004905 obo:IAO_0000115 "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts." ; oboInOwl:hasDbXref "FBbt:00005811" ; oboInOwl:hasNarrowSynonym "joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004905" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "articulation" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004770 ] . obo:UBERON_0004906 obo:IAO_0000115 "A portion of the gut that is derived from ectoderm." ; oboInOwl:hasExactSynonym "ectodermal gut", "gut ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004906" ; a owl:Class ; rdfs:label "ectodermal part of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004921 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0004907 obo:IAO_0000115 "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." ; obo:UBPROP_0000012 "MA class was moved from here. See https://github.com/obophenotype/uberon/issues/509", "WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L" ; oboInOwl:hasBroadSynonym "gut" ; oboInOwl:hasDbXref "FMA:49179", "NCIT:C33010", "SCTID:279973004", "UMLS:C0226875", "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract", "galen:LowerGastrointestinalTract" ; oboInOwl:hasExactSynonym "lower GI tract", "lower gastrointestinal tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004907" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "lower digestive tract" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ], _:genid137033 . obo:UBERON_0004908 obo:IAO_0000115 "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." ; obo:UBPROP_0000012 "WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L. In Galen, entire GI tract excludes esophagus" ; oboInOwl:hasDbXref "FMA:49177", "NCIT:C33837", "SCTID:181244000", "UMLS:C0226874", "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract", "galen:UpperGastrointestinalTract" ; oboInOwl:hasExactSynonym "upper GI tract", "upper gastrointestinal tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004908" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "upper digestive tract" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 ] . obo:UBERON_0004909 obo:IAO_0000115 "An epithelium surrounding a gonad." ; obo:IAO_0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" ; oboInOwl:hasDbXref "EHDAA:4032", "EHDAA:5931", "NCIT:C32676", "UMLS:C1517534" ; oboInOwl:hasExactSynonym "gonad epithelium", "gonadal epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gonadal sheath" ; oboInOwl:id "UBERON:0004909" ; a owl:Class ; rdfs:label "epithelium of gonad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000991 ] ) ] . obo:UBERON_0004910 obo:IAO_0000115 "An epithelium surrounding a testis." ; obo:IAO_0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" ; oboInOwl:hasDbXref "BTO:0001364", "EMAPA:17973" ; oboInOwl:hasExactSynonym "testis epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004910" ; a owl:Class ; rdfs:label "epithelium of male gonad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] . obo:UBERON_0004911 obo:IAO_0000115 "An epithelium surrounding an ovary." ; obo:IAO_0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" ; oboInOwl:hasDbXref "BTO:0003661" ; oboInOwl:hasExactSynonym "ovarian epithelium", "ovary epithelium" ; oboInOwl:hasNarrowSynonym "ovarian sheath" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004911" ; a owl:Class ; rdfs:label "epithelium of female gonad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0004912 oboInOwl:hasDbXref "EHDAA2:0000171", "EMAPA:16561", "EMAPA_RETIRED:16565", "VHOG:0001351" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic diverticulum" ; oboInOwl:id "UBERON:0004912" ; a owl:Class ; rdfs:label "biliary bud" ; rdfs:subClassOf obo:UBERON_0007499, _:genid138339, _:genid138341, _:genid138343 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png"^^xsd:anyURI . obo:UBERON_0004913 obo:IAO_0000115 "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." ; obo:UBPROP_0000001 "Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO]" ; oboInOwl:hasDbXref "CALOHA:TS-2348", "FMA:15076", "GAID:283", "MESH:D014670", "NCIT:C13011", "SCTID:362200007", "TAO:0005167", "UMLS:C0042425", "Wikipedia:Ampulla_of_Vater", "ZFA:0005167", "galen:AmpullaOfVater" ; oboInOwl:hasExactSynonym "Vater's ampulla", "ampulla biliaropancreatica", "ampulla of Vater", "ampulla of bile duct", "biliaropancreatic ampulla", "papilla Vateri" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ampulla Vaterii", "ampulla hepatopancreatica", "papilla duodeni major" ; oboInOwl:id "UBERON:0004913" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatopancreatic ampulla" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001174 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004914 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg"^^xsd:anyURI . obo:UBERON_0004914 obo:IAO_0000115 "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." ; oboInOwl:hasDbXref "EMAPA:18662", "FMA:15953", "MA:0003107", "NCIT:C119578", "SCTID:245389007" ; oboInOwl:hasExactSynonym "papilla duodenalis", "papilla of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "papilla duodeni" ; oboInOwl:id "UBERON:0004914" ; a owl:Class ; rdfs:label "duodenal papilla" ; rdfs:subClassOf obo:UBERON_0034944, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000320 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png"^^xsd:anyURI . obo:UBERON_0004915 obo:IAO_0000115 "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." ; oboInOwl:hasDbXref "EMAPA:18663", "FMA:15077", "GAID:285", "MESH:D009803", "NCIT:C13065", "SCTID:181271000", "UMLS:C0028872", "Wikipedia:Sphincter_of_ampulla" ; oboInOwl:hasExactSynonym "Oddi's sphincter", "hepatopancreatic ampullary sphincter", "musculus sphincter ampullae", "musculus sphincter ampullae hepatopancreatica", "sphincter of Oddi", "sphincter of ampulla of vater" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004915" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sphincter of hepatopancreatic ampulla" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004913 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png"^^xsd:anyURI . obo:UBERON_0004916 obo:IAO_0000115 "A sphincter muscle that is part of a anal region." ; oboInOwl:hasDbXref "EMAPA:36052" ; oboInOwl:hasExactSynonym "anal region sphincter", "sphincter analia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004916" ; a owl:Class ; rdfs:label "anal sphincter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0030421 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] ) ] . obo:UBERON_0004917 obo:IAO_0000115 "A sphincter muscle surrounding the urethra." ; oboInOwl:hasDbXref "EMAPA:37789", "MA:0002650", "SCTID:277855007", "SCTID:277857004", "Wikipedia:Urethral_sphincter" ; oboInOwl:hasExactSynonym "sphincter muscle of urethra", "sphincter of urethra", "sphincter urethrae", "urethral sphincter muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004917" ; a owl:Class ; rdfs:label "urethral sphincter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0004919 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "EMAPA:37790", "FMA:85274", "MA:0002401", "NCIT:C52561", "SCTID:19101001", "UMLS:C1710586" ; oboInOwl:hasExactSynonym "annulus urethralis", "external sphincter muscle of urethra", "external sphincter of urethra", "external urethral sphincter muscle", "m. urethralis", "urethralis", "urethralis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus sphincter urethrae membranaceae" ; oboInOwl:id "UBERON:0004919" ; a owl:Class ; rdfs:label "external urethral sphincter" ; rdfs:subClassOf obo:UBERON_0004590, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ], _:genid138388, _:genid138390 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/70/Gray1166.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray1142.png"^^xsd:anyURI . obo:UBERON_0004921 obo:IAO_0000115 "A proximal-distal subdivision of the digestive tract." ; obo:IAO_0000232 "intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct." ; oboInOwl:hasDbXref "FBbt:00100315", "FMA:71131" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "alimentary system subdivision", "gut section", "intestinal tract", "segment of intestinal tract", "subdivision of alimentary system" ; oboInOwl:id "UBERON:0004921" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of digestive tract" ; rdfs:subClassOf _:genid137126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0004923 obo:IAO_0000115 "A part of a wall of an organ that forms a layer." ; oboInOwl:hasDbXref "FMA:82485" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004923" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "organ component layer" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000060 ] . obo:UBERON_0004924 obo:IAO_0000115 "The tissue underlying the tunica mucosa of the pharynx." ; oboInOwl:hasDbXref "BTO:0002113", "FMA:75144", "SCTID:19594009" ; oboInOwl:hasExactSynonym "pharyngeal submucosa", "pharynx submucosa", "tela submucosa pharyngea", "tela submucosa pharyngis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngobasilar fascia", "submucous coat of pharynx", "submucous layer of pharynx" ; oboInOwl:id "UBERON:0004924" ; a owl:Class ; rdfs:label "submucosa of pharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0004925 obo:IAO_0000115 "A submucosa that is part of a hypopharynx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:55072", "SCTID:47496006" ; oboInOwl:hasExactSynonym "hypopharynx submucosa", "laryngeal pharynx submucosa", "laryngopharynx submucosa", "submucosa of hypopharynx", "submucosa of laryngeal pharynx", "tela submucosa (pars laryngea pharyngis)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004925" ; a owl:Class ; rdfs:label "submucosa of laryngopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 ] ) ] . obo:UBERON_0004926 obo:IAO_0000115 "A submucosa that is part of a cystic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18013" ; oboInOwl:hasExactSynonym "cystic duct submucosa", "cystic ductal submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004926" ; a owl:Class ; rdfs:label "submucosa of cystic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001152 ] ) ] . obo:UBERON_0004931 obo:IAO_0000115 "A submucosa that is part of a descending colon [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:15020" ; oboInOwl:hasExactSynonym "descending colon submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004931" ; a owl:Class ; rdfs:label "submucosa of descending colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001158 ] ) ] . obo:UBERON_0004932 obo:IAO_0000115 "A submucosa that is part of a sigmoid colon [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:15027" ; oboInOwl:hasExactSynonym "sigmoid colon submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004932" ; a owl:Class ; rdfs:label "submucosa of sigmoid colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_0004934 obo:IAO_0000115 "A submucosa that is part of a body of stomach [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17059" ; oboInOwl:hasExactSynonym "body of stomach submucosa", "corpus gastricum (ventriculare) submucosa", "gastric body submucosa", "stomach body submucosa", "submucosa of corpus gastricum (ventriculare)", "submucosa of gastric body", "submucosa of stomach body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004934" ; a owl:Class ; rdfs:label "submucosa of body of stomach" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001161 ] ) ] . obo:UBERON_0004936 obo:IAO_0000115 "A submucosa that is part of a pyloric antrum [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17060" ; oboInOwl:hasExactSynonym "antrum of stomach submucosa", "pyloric antrum submucosa", "stomach pyloric antrum submucosa", "submucosa of antrum of stomach", "submucosa of stomach pyloric antrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004936" ; a owl:Class ; rdfs:label "submucosa of pyloric antrum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001165 ] ) ] . obo:UBERON_0004937 obo:IAO_0000115 "A submucosa that is part of a pylorus [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:27201", "FMA:17462" ; oboInOwl:hasExactSynonym "pyloric part of stomach submucosa", "pyloric submucosa", "pylorus submucosa", "stomach pyloric region submucosa", "submucosa of pyloric part of stomach", "submucosa of stomach pyloric region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004937" ; a owl:Class ; rdfs:label "submucosa of pylorus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001166 ] ) ] . obo:UBERON_0004938 obo:IAO_0000115 "A submucosa that is part of a biliary tree [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18009" ; oboInOwl:hasExactSynonym "biliary tract submucosa", "biliary tree submucosa", "submucosa of biliary tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004938" ; a owl:Class ; rdfs:label "submucosa of biliary tree" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 ] ) ] . obo:UBERON_0004939 obo:IAO_0000115 "A submucosa that is part of a common bile duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18011" ; oboInOwl:hasExactSynonym "common bile duct submucosa", "common bile ductal submucosa", "ductus choledochus (biliaris) submucosa", "submucosa of ductus choledochus (biliaris)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004939" ; a owl:Class ; rdfs:label "submucosa of common bile duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001174 ] ) ] . obo:UBERON_0004940 obo:IAO_0000115 "A submucosa that is part of a common hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18014" ; oboInOwl:hasExactSynonym "common hepatic duct submucosa", "common hepatic ductal submucosa", "hepatic duct submucosa", "submucosa of hepatic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004940" ; a owl:Class ; rdfs:label "submucosa of common hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 _:genid137225 ) ] . obo:UBERON_0004941 obo:IAO_0000115 "A submucosa that is part of a right hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18015" ; oboInOwl:hasExactSynonym "right hepatic duct submucosa", "right hepatic ductal submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004941" ; a owl:Class ; rdfs:label "submucosa of right hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001176 ] ) ] . obo:UBERON_0004942 obo:IAO_0000115 "A submucosa that is part of a left hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18017" ; oboInOwl:hasExactSynonym "left hepatic duct submucosa", "left hepatic ductal submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004942" ; a owl:Class ; rdfs:label "submucosa of left hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001177 ] ) ] . obo:UBERON_0004943 obo:IAO_0000115 "The submucous layer of the wall of the urinary bladder." ; oboInOwl:hasDbXref "BTO:0002117", "EMAPA:32275", "FMA:15929", "SCTID:88384001" ; oboInOwl:hasExactSynonym "bladder submucosa", "submucosa of bladder", "tela submucosa (vesica urinaria)", "tela submucosa vesicae", "tela submucosa vesicae urinariae", "urinary bladder submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of urinary bladder" ; oboInOwl:id "UBERON:0004943" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of urinary bladder" ; rdfs:subClassOf _:genid138527 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0004945 obo:IAO_0000115 "A submucosa that is part of a neck of urinary bladder [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32276", "FMA:17851" ; oboInOwl:hasExactSynonym "bladder neck submucosa", "neck of bladder submucosa", "neck of urinary bladder submucosa", "submucosa of bladder neck", "submucosa of neck of bladder", "submucosa of urinary bladder neck", "submucosa of vesical neck", "urinary bladder neck submucosa", "vesical neck submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004945" ; a owl:Class ; rdfs:label "submucosa of neck of urinary bladder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001258 ] ) ] . obo:UBERON_0004946 obo:IAO_0000115 "A submucosa that is part of a ileum [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14957", "SCTID:65374006" ; oboInOwl:hasExactSynonym "ileal submucosa", "ileum submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004946" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "submucosa of ileum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0004952 obo:IAO_0000115 "A submucosa that is part of a bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:62775" ; oboInOwl:hasExactSynonym "bronchiole submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004952" ; a owl:Class ; rdfs:label "submucosa of bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:UBERON_0004980 obo:IAO_0000115 "A mucosa that is part of a ureter [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:15894", "SCTID:40476001", "galen:MucousMembraneOfUreter" ; oboInOwl:hasExactSynonym "mucosa of organ of ureter", "mucosal layer of ureter", "mucous membrane of ureter", "organ mucosa of ureter", "tunica mucosa (ureter)", "tunica mucosa ureteris", "ureter mucosa", "ureter mucosa of organ", "ureter mucous membrane", "ureter organ mucosa", "ureteral mucosa", "ureteric mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004980" ; a owl:Class ; rdfs:label "mucosa of ureter" ; rdfs:subClassOf _:genid138568 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0004982 obo:IAO_0000115 "A mucosa that is part of a epiglottis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:64015", "SCTID:156751001" ; oboInOwl:hasExactSynonym "epiglottis mucosa", "epiglottis mucosa of organ", "epiglottis mucous membrane", "epiglottis organ mucosa", "mucosa of organ of epiglottis", "mucous membrane of epiglottis", "organ mucosa of epiglottis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004982" ; a owl:Class ; rdfs:label "mucosa of epiglottis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000388 ] ) ] . obo:UBERON_0004983 obo:IAO_0000115 "A mucosa that is part of a vagina [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0005676", "FMA:19975", "SCTID:362245006" ; oboInOwl:hasExactSynonym "mucosa of organ of vagina", "mucous membrane of vagina", "organ mucosa of vagina", "tunica mucosa vaginae", "vagina mucosa", "vagina mucosa of organ", "vagina mucous membrane", "vagina organ mucosa", "vaginal mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004983" ; a owl:Class ; rdfs:label "mucosa of vagina" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0004984 obo:IAO_0000115 "A mucosa that is part of a seminal vesicle [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:19405", "SCTID:252260007" ; oboInOwl:hasExactSynonym "mucosa of organ of seminal gland", "mucosa of organ of seminal vesicle", "mucosa of seminal gland", "mucous membrane of seminal gland", "mucous membrane of seminal vesicle", "organ mucosa of seminal gland", "organ mucosa of seminal vesicle", "seminal gland mucosa", "seminal gland mucosa of organ", "seminal gland mucous membrane", "seminal gland organ mucosa", "seminal vesicle mucosa", "seminal vesicle mucosa of organ", "seminal vesicle mucous membrane", "seminal vesicle organ mucosa", "tunica mucosa glandulae vesiculosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004984" ; a owl:Class ; rdfs:label "mucosa of seminal vesicle" ; owl:equivalentClass _:genid137330 . obo:UBERON_0004985 obo:IAO_0000115 "A mucosa that is part of a ejaculatory duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:19373" ; oboInOwl:hasExactSynonym "ejaculatory duct mucosa", "ejaculatory duct mucosa of organ", "ejaculatory duct mucous membrane", "ejaculatory duct organ mucosa", "ejaculatory ductal mucosa", "mucosa of organ of ejaculatory duct", "mucous membrane of ejaculatory duct", "organ mucosa of ejaculatory duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004985" ; a owl:Class ; rdfs:label "mucosa of ejaculatory duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000999 ] ) ] . obo:UBERON_0004986 obo:IAO_0000115 "A mucosa that is part of a vas deferens [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:19240", "SCTID:299626000" ; oboInOwl:hasExactSynonym "deferent duct mucosa", "deferent duct mucosa of organ", "deferent duct mucous membrane", "deferent duct organ mucosa", "deferent ductal mucosa", "ductus deferens mucosa", "ductus deferens mucosa of organ", "ductus deferens mucous membrane", "ductus deferens organ mucosa", "mucosa of ductus deferens", "mucosa of organ of deferent duct", "mucosa of organ of ductus deferens", "mucosa of organ of sperm duct", "mucosa of organ of vas deferen", "mucosa of organ of vas deferens", "mucosa of sperm duct", "mucosa of vas deferen", "mucosa of vas deferens", "mucous membrane of deferent duct", "mucous membrane of ductus deferens", "mucous membrane of sperm duct", "mucous membrane of vas deferen", "mucous membrane of vas deferens", "organ mucosa of deferent duct", "organ mucosa of ductus deferens", "organ mucosa of sperm duct", "organ mucosa of vas deferen", "organ mucosa of vas deferens", "sperm duct mucosa", "sperm duct mucosa of organ", "sperm duct mucous membrane", "sperm duct organ mucosa", "tunica mucosa (ductus deferens)", "tunica mucosa ductus deferentis", "vas deferen mucosa", "vas deferen mucosa of organ", "vas deferen mucous membrane", "vas deferen organ mucosa", "vas deferens mucosa", "vas deferens mucosa of organ", "vas deferens mucous membrane", "vas deferens organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004986" ; a owl:Class ; rdfs:label "mucosa of deferent duct" ; owl:equivalentClass _:genid137364 . obo:UBERON_0004987 obo:IAO_0000115 "A mucosa that is part of a hypopharynx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:55030", "SCTID:362126008" ; oboInOwl:hasExactSynonym "hypopharynx mucosa", "hypopharynx mucosa of organ", "hypopharynx mucous membrane", "hypopharynx organ mucosa", "laryngeal pharynx mucosa", "laryngeal pharynx mucosa of organ", "laryngeal pharynx mucous membrane", "laryngeal pharynx organ mucosa", "laryngopharynx mucosa", "laryngopharynx mucosa of organ", "laryngopharynx mucous membrane", "laryngopharynx organ mucosa", "mucosa of hypopharynx", "mucosa of laryngeal pharynx", "mucosa of organ of hypopharynx", "mucosa of organ of laryngeal pharynx", "mucosa of organ of laryngopharynx", "mucous membrane of hypopharynx", "mucous membrane of laryngeal pharynx", "mucous membrane of laryngopharynx", "organ mucosa of hypopharynx", "organ mucosa of laryngeal pharynx", "organ mucosa of laryngopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004987" ; a owl:Class ; rdfs:label "mucosa of laryngopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 ] ) ] . obo:UBERON_0004988 obo:IAO_0000115 "A mucosa that is part of a cystic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14690" ; oboInOwl:hasExactSynonym "cystic duct mucosa", "cystic duct mucosa of organ", "cystic duct mucous membrane", "cystic duct organ mucosa", "cystic ductal mucosa", "mucosa of organ of cystic duct", "mucous membrane of cystic duct", "organ mucosa of cystic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004988" ; a owl:Class ; rdfs:label "mucosa of cystic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001152 ] ) ] . obo:UBERON_0004992 obo:IAO_0000115 "A mucosa that is part of a descending colon [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:15019" ; oboInOwl:hasExactSynonym "descending colon mucosa", "descending colon mucosa of organ", "descending colon mucous membrane", "descending colon organ mucosa", "mucosa of organ of descending colon", "mucous membrane of descending colon", "organ mucosa of descending colon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004992" ; a owl:Class ; rdfs:label "mucosa of descending colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001158 ] ) ] . obo:UBERON_0004993 obo:IAO_0000115 "A mucosa that is part of a sigmoid colon [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:15026" ; oboInOwl:hasExactSynonym "mucosa of organ of sigmoid colon", "mucous membrane of sigmoid colon", "organ mucosa of sigmoid colon", "sigmoid colon mucosa", "sigmoid colon mucosa of organ", "sigmoid colon mucous membrane", "sigmoid colon organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004993" ; a owl:Class ; rdfs:label "mucosa of sigmoid colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_0004995 obo:IAO_0000115 "A mucosa that is part of a body of stomach [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17054" ; oboInOwl:hasExactSynonym "body of stomach mucosa", "body of stomach mucosa of organ", "body of stomach mucous membrane", "body of stomach organ mucosa", "corpus gastricum (ventriculare) mucosa", "corpus gastricum (ventriculare) mucosa of organ", "corpus gastricum (ventriculare) mucous membrane", "corpus gastricum (ventriculare) organ mucosa", "gastric body mucosa", "gastric body mucosa of organ", "gastric body mucous membrane", "gastric body organ mucosa", "mucosa of corpus gastricum (ventriculare)", "mucosa of gastric body", "mucosa of organ of body of stomach", "mucosa of organ of corpus gastricum (ventriculare)", "mucosa of organ of gastric body", "mucosa of organ of stomach body", "mucosa of stomach body", "mucous membrane of body of stomach", "mucous membrane of corpus gastricum (ventriculare)", "mucous membrane of gastric body", "mucous membrane of stomach body", "organ mucosa of body of stomach", "organ mucosa of corpus gastricum (ventriculare)", "organ mucosa of gastric body", "organ mucosa of stomach body", "stomach body mucosa", "stomach body mucosa of organ", "stomach body mucous membrane", "stomach body organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004995" ; a owl:Class ; rdfs:label "mucosa of body of stomach" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001161 ] ) ] . obo:UBERON_0004997 obo:IAO_0000115 "A mucosa that is part of a pyloric antrum [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004107", "FMA:17055" ; oboInOwl:hasExactSynonym "antral mucosa", "antrum of stomach mucosa", "antrum of stomach mucosa of organ", "antrum of stomach mucous membrane", "antrum of stomach organ mucosa", "mucosa of antrum of stomach", "mucosa of organ of antrum of stomach", "mucosa of organ of pyloric antrum", "mucosa of organ of stomach pyloric antrum", "mucosa of stomach pyloric antrum", "mucous membrane of antrum of stomach", "mucous membrane of pyloric antrum", "mucous membrane of stomach pyloric antrum", "organ mucosa of antrum of stomach", "organ mucosa of pyloric antrum", "organ mucosa of stomach pyloric antrum", "pyloric antrum mucosa", "pyloric antrum mucosa of organ", "pyloric antrum mucous membrane", "pyloric antrum organ mucosa", "stomach pyloric antrum mucosa", "stomach pyloric antrum mucosa of organ", "stomach pyloric antrum mucous membrane", "stomach pyloric antrum organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric antrum mucosa" ; oboInOwl:id "UBERON:0004997" ; a owl:Class ; rdfs:label "mucosa of pyloric antrum" ; rdfs:subClassOf _:genid138795 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001165 ] ) ] . obo:UBERON_0004998 obo:IAO_0000115 "A mucosa that is part of a pylorus [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004110", "EMAPA:27199", "FMA:17461" ; oboInOwl:hasExactSynonym "mucosa of organ of pyloric part of stomach", "mucosa of organ of pylorus", "mucosa of organ of stomach pyloric region", "mucosa of pyloric part of stomach", "mucosa of stomach pyloric region", "mucous membrane of pyloric part of stomach", "mucous membrane of pylorus", "mucous membrane of stomach pyloric region", "organ mucosa of pyloric part of stomach", "organ mucosa of pylorus", "organ mucosa of stomach pyloric region", "pyloric part of stomach mucosa", "pyloric part of stomach mucosa of organ", "pyloric part of stomach mucous membrane", "pyloric part of stomach organ mucosa", "pylorus mucosa", "pylorus mucosa of organ", "pylorus mucous membrane", "pylorus organ mucosa", "stomach pyloric region mucosa", "stomach pyloric region mucosa of organ", "stomach pyloric region mucous membrane", "stomach pyloric region organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "antropyloric mucosa" ; oboInOwl:id "UBERON:0004998" ; a owl:Class ; rdfs:label "mucosa of pylorus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001166 ] ) ] . obo:UBERON_0004999 obo:IAO_0000115 "A mucosa that is part of a biliary tree [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14695" ; oboInOwl:hasExactSynonym "biliary tract mucosa", "biliary tract mucosa of organ", "biliary tract mucous membrane", "biliary tract organ mucosa", "biliary tree mucosa", "biliary tree mucosa of organ", "biliary tree mucous membrane", "biliary tree organ mucosa", "mucosa of biliary tract", "mucosa of organ of biliary tract", "mucosa of organ of biliary tree", "mucous membrane of biliary tract", "mucous membrane of biliary tree", "organ mucosa of biliary tract", "organ mucosa of biliary tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0004999" ; a owl:Class ; rdfs:label "mucosa of biliary tree" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 ] ) ] . obo:UBERON_0005000 obo:IAO_0000115 "A mucosa that is part of a common bile duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14688" ; oboInOwl:hasExactSynonym "common bile duct mucosa", "common bile duct mucosa of organ", "common bile duct mucous membrane", "common bile duct organ mucosa", "common bile ductal mucosa", "ductus choledochus (biliaris) mucosa", "ductus choledochus (biliaris) mucosa of organ", "ductus choledochus (biliaris) mucous membrane", "ductus choledochus (biliaris) organ mucosa", "mucosa of ductus choledochus (biliaris)", "mucosa of organ of common bile duct", "mucosa of organ of ductus choledochus (biliaris)", "mucous membrane of common bile duct", "mucous membrane of ductus choledochus (biliaris)", "organ mucosa of common bile duct", "organ mucosa of ductus choledochus (biliaris)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005000" ; a owl:Class ; rdfs:label "mucosa of common bile duct" ; owl:equivalentClass _:genid137592 . obo:UBERON_0005001 obo:IAO_0000115 "A mucosa that is part of a common hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14691" ; oboInOwl:hasExactSynonym "common hepatic duct mucosa", "common hepatic duct mucosa of organ", "common hepatic duct mucous membrane", "common hepatic duct organ mucosa", "common hepatic ductal mucosa", "hepatic duct mucosa", "hepatic duct mucosa of organ", "hepatic duct mucous membrane", "hepatic duct organ mucosa", "mucosa of hepatic duct", "mucosa of organ of common hepatic duct", "mucosa of organ of hepatic duct", "mucous membrane of common hepatic duct", "mucous membrane of hepatic duct", "organ mucosa of common hepatic duct", "organ mucosa of hepatic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005001" ; a owl:Class ; rdfs:label "mucosa of common hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001175 ] ) ] . obo:UBERON_0005002 obo:IAO_0000115 "A mucosa that is part of a right hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14692" ; oboInOwl:hasExactSynonym "mucosa of organ of right hepatic duct", "mucous membrane of right hepatic duct", "organ mucosa of right hepatic duct", "right hepatic duct mucosa", "right hepatic duct mucosa of organ", "right hepatic duct mucous membrane", "right hepatic duct organ mucosa", "right hepatic ductal mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005002" ; a owl:Class ; rdfs:label "mucosa of right hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001176 ] ) ] . obo:UBERON_0005003 obo:IAO_0000115 "A mucosa that is part of a left hepatic duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14693" ; oboInOwl:hasExactSynonym "left hepatic duct mucosa", "left hepatic duct mucosa of organ", "left hepatic duct mucous membrane", "left hepatic duct organ mucosa", "left hepatic ductal mucosa", "mucosa of organ of left hepatic duct", "mucous membrane of left hepatic duct", "organ mucosa of left hepatic duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005003" ; a owl:Class ; rdfs:label "mucosa of left hepatic duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001177 ] ) ] . obo:UBERON_0005004 obo:IAO_0000115 "A mucosa that is part of a right ureter [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17806" ; oboInOwl:hasExactSynonym "mucosa of organ of right ureter", "mucous membrane of right ureter", "organ mucosa of right ureter", "right ureter mucosa", "right ureter mucosa of organ", "right ureter mucous membrane", "right ureter organ mucosa", "right ureteral mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005004" ; a owl:Class ; rdfs:label "mucosa of right ureter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001222 ] ) ] . obo:UBERON_0005005 obo:IAO_0000115 "A mucosa that is part of a left ureter [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17807" ; oboInOwl:hasExactSynonym "left ureter mucosa", "left ureter mucosa of organ", "left ureter mucous membrane", "left ureter organ mucosa", "left ureteral mucosa", "mucosa of organ of left ureter", "mucous membrane of left ureter", "organ mucosa of left ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005005" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mucosa of left ureter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001223 ] ) ] . obo:UBERON_0005006 obo:IAO_0000115 "A mucosa that is part of a renal pelvis [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17931", "SCTID:243482002" ; oboInOwl:hasExactSynonym "kidney pelvis mucosa", "kidney pelvis mucosa of organ", "kidney pelvis mucous membrane", "kidney pelvis organ mucosa", "mucosa of kidney pelvis", "mucosa of organ of kidney pelvis", "mucosa of organ of pelvis of ureter", "mucosa of organ of renal pelvis", "mucosa of pelvis of ureter", "mucous membrane of kidney pelvis", "mucous membrane of pelvis of ureter", "mucous membrane of renal pelvis", "organ mucosa of kidney pelvis", "organ mucosa of pelvis of ureter", "organ mucosa of renal pelvis", "pelvis of ureter mucosa", "pelvis of ureter mucosa of organ", "pelvis of ureter mucous membrane", "pelvis of ureter organ mucosa", "renal pelvic mucosa", "renal pelvis mucosa", "renal pelvis mucosa of organ", "renal pelvis mucous membrane", "renal pelvis organ mucosa", "tunica mucosa pelvis renalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005006" ; a owl:Class ; rdfs:label "mucosa of renal pelvis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ] ) ] . obo:UBERON_0005010 obo:IAO_0000115 "A mucosa that is part of a neck of urinary bladder [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:17846" ; oboInOwl:hasExactSynonym "bladder neck mucosa", "bladder neck mucosa of organ", "bladder neck mucous membrane", "bladder neck organ mucosa", "mucosa of bladder neck", "mucosa of neck of bladder", "mucosa of organ of bladder neck", "mucosa of organ of neck of bladder", "mucosa of organ of neck of urinary bladder", "mucosa of organ of urinary bladder neck", "mucosa of organ of vesical neck", "mucosa of urinary bladder neck", "mucosa of vesical neck", "mucous membrane of bladder neck", "mucous membrane of neck of bladder", "mucous membrane of neck of urinary bladder", "mucous membrane of urinary bladder neck", "mucous membrane of vesical neck", "neck of bladder mucosa", "neck of bladder mucosa of organ", "neck of bladder mucous membrane", "neck of bladder organ mucosa", "neck of urinary bladder mucosa", "neck of urinary bladder mucosa of organ", "neck of urinary bladder mucous membrane", "neck of urinary bladder organ mucosa", "organ mucosa of bladder neck", "organ mucosa of neck of bladder", "organ mucosa of neck of urinary bladder", "organ mucosa of urinary bladder neck", "organ mucosa of vesical neck", "urinary bladder neck mucosa", "urinary bladder neck mucosa of organ", "urinary bladder neck mucous membrane", "vesical neck mucosa", "vesical neck mucosa of organ", "vesical neck mucous membrane", "vesical neck organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005010" ; a owl:Class ; rdfs:label "mucosa of neck of urinary bladder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001258 ] ) ] . obo:UBERON_0005011 obo:IAO_0000115 "A mucosa that is part of a right uterine tube [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18452" ; oboInOwl:hasExactSynonym "mucosa of organ of right fallopian tube", "mucosa of organ of right oviduct", "mucosa of organ of right uterine tube", "mucosa of right fallopian tube", "mucosa of right oviduct", "mucous membrane of right fallopian tube", "mucous membrane of right oviduct", "mucous membrane of right uterine tube", "organ mucosa of right fallopian tube", "organ mucosa of right oviduct", "organ mucosa of right uterine tube", "right fallopian tube mucosa", "right fallopian tube mucosa of organ", "right fallopian tube mucous membrane", "right fallopian tube organ mucosa", "right oviduct mucosa", "right oviduct mucosa of organ", "right oviduct mucous membrane", "right oviduct organ mucosa", "right uterine tube mucosa", "right uterine tube mucosa of organ", "right uterine tube mucous membrane", "right uterine tube organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005011" ; a owl:Class ; rdfs:label "mucosa of right uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001302 ] ) ] . obo:UBERON_0005012 obo:IAO_0000115 "A mucosa that is part of a left uterine tube [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18453" ; oboInOwl:hasExactSynonym "left fallopian tube mucosa", "left fallopian tube mucosa of organ", "left fallopian tube mucous membrane", "left fallopian tube organ mucosa", "left oviduct mucosa", "left oviduct mucosa of organ", "left oviduct mucous membrane", "left oviduct organ mucosa", "left uterine tube mucosa", "left uterine tube mucosa of organ", "left uterine tube mucous membrane", "left uterine tube organ mucosa", "mucosa of left fallopian tube", "mucosa of left oviduct", "mucosa of organ of left fallopian tube", "mucosa of organ of left oviduct", "mucosa of organ of left uterine tube", "mucous membrane of left fallopian tube", "mucous membrane of left oviduct", "mucous membrane of left uterine tube", "organ mucosa of left fallopian tube", "organ mucosa of left oviduct", "organ mucosa of left uterine tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005012" ; a owl:Class ; rdfs:label "mucosa of left uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001303 ] ) ] . obo:UBERON_0005013 obo:IAO_0000115 "A mucosa that is part of a male urethra [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:239937" ; oboInOwl:hasExactSynonym "male urethra mucosa", "male urethra mucosa of organ", "male urethra mucous membrane", "male urethra organ mucosa", "mucosa of organ of male urethra", "mucous membrane of male urethra", "organ mucosa of male urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005013" ; a owl:Class ; rdfs:label "mucosa of male urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 ] ) ] . obo:UBERON_0005014 obo:IAO_0000115 "A mucosa that is part of a female urethra [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:239940" ; oboInOwl:hasExactSynonym "female urethra mucosa", "female urethra mucosa of organ", "female urethra mucous membrane", "female urethra organ mucosa", "mucosa of organ of female urethra", "mucous membrane of female urethra", "organ mucosa of female urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005014" ; a owl:Class ; rdfs:label "mucosa of female urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:UBERON_0005017 obo:IAO_0000115 "A mucosa that is part of a lacrimal sac [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:72061" ; oboInOwl:hasExactSynonym "lacrimal sac mucosa", "lacrimal sac mucosa of organ", "lacrimal sac mucous membrane", "lacrimal sac organ mucosa", "mucosa of organ of lacrimal sac", "mucous membrane of lacrimal sac", "organ mucosa of lacrimal sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005017" ; a owl:Class ; rdfs:label "mucosa of lacrimal sac" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001351 ] ) ] . obo:UBERON_0005018 obo:IAO_0000115 "A mucosa that is part of a nasal septum [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36028", "FMA:60113" ; oboInOwl:hasExactSynonym "mucosa of organ of nasal septum", "mucous membrane of nasal septum", "nasal septum mucosa", "nasal septum mucosa of organ", "nasal septum mucous membrane", "nasal septum organ mucosa", "organ mucosa of nasal septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005018" ; a owl:Class ; rdfs:label "mucosa of nasal septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001706 ] ) ] . obo:UBERON_0005019 obo:IAO_0000115 "A mucosa that is part of a palate [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59765" ; oboInOwl:hasExactSynonym "mucosa of oral roof", "mucosa of organ of oral roof", "mucosa of organ of palate", "mucosa of organ of roof of mouth", "mucosa of roof of mouth", "mucous membrane of oral roof", "mucous membrane of palate", "mucous membrane of roof of mouth", "oral roof mucosa", "oral roof mucosa of organ", "oral roof mucous membrane", "oral roof organ mucosa", "organ mucosa of oral roof", "organ mucosa of palate", "organ mucosa of roof of mouth", "palate mucosa", "palate mucosa of organ", "palate mucous membrane", "palate organ mucosa", "roof of mouth mucosa", "roof of mouth mucosa of organ", "roof of mouth mucous membrane", "roof of mouth organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005019" ; a owl:Class ; rdfs:label "mucosa of palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001716 ] ) ] . obo:UBERON_0005020 obo:IAO_0000115 "A mucosa that is part of a tongue [Automatically generated definition]." ; oboInOwl:hasDbXref "EFO:0002553", "FMA:54807", "SCTID:362092002" ; oboInOwl:hasExactSynonym "lingual mucosa", "mucosa of organ of tongue", "mucous membrane of tongue", "organ mucosa of tongue", "tongue mucosa", "tongue mucosa of organ", "tongue mucous membrane", "tongue organ mucosa", "tunica mucosa linguae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005020" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "mucosa of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0005021 obo:IAO_0000115 "A mucosa that is part of a sphenoidal sinus [Automatically generated definition]." ; obo:IAO_0000116 "decide whether cavities can be part of mucosae" ; oboInOwl:hasDbXref "FMA:59775", "SCTID:43774000" ; oboInOwl:hasExactSynonym "mucosa of organ of sphenoid sinus", "mucosa of organ of sphenoidal sinus", "mucosa of sphenoid sinus", "mucous membrane of sphenoid sinus", "mucous membrane of sphenoidal sinus", "organ mucosa of sphenoid sinus", "organ mucosa of sphenoidal sinus", "sphenoid sinus mucosa", "sphenoid sinus mucosa of organ", "sphenoid sinus mucous membrane", "sphenoid sinus organ mucosa", "sphenoidal sinus mucosa", "sphenoidal sinus mucosa of organ", "sphenoidal sinus mucous membrane", "sphenoidal sinus organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005021" ; a owl:Class ; rdfs:label "mucosa of sphenoidal sinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass _:genid137905 . obo:UBERON_0005022 obo:IAO_0000115 "A mucosa that is part of a nasopharynx [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:54971", "SCTID:361938001" ; oboInOwl:hasExactSynonym "mucosa of nasal part of pharynx", "mucosa of organ of nasal part of pharynx", "mucosa of organ of nasopharynx", "mucosa of organ of rhinopharynx", "mucosa of rhinopharynx", "mucous membrane of nasal part of pharynx", "mucous membrane of nasopharynx", "mucous membrane of rhinopharynx", "nasal part of pharynx mucosa", "nasal part of pharynx mucosa of organ", "nasal part of pharynx mucous membrane", "nasal part of pharynx organ mucosa", "nasopharynx mucosa", "nasopharynx mucosa of organ", "nasopharynx mucous membrane", "nasopharynx organ mucosa", "organ mucosa of nasal part of pharynx", "organ mucosa of nasopharynx", "organ mucosa of rhinopharynx", "rhinopharynx mucosa", "rhinopharynx mucosa of organ", "rhinopharynx mucous membrane", "rhinopharynx organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005022" ; a owl:Class ; rdfs:label "mucosa of nasopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0005024 obo:IAO_0000115 "A mucosa that is part of a soft palate [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59784", "SCTID:245842003", "Wikipedia:Mucous_membrane_of_the_soft_palate" ; oboInOwl:hasExactSynonym "mucosa of organ of soft palate", "mucous membrane of soft palate", "organ mucosa of soft palate", "soft palate mucosa", "soft palate mucosa of organ", "soft palate mucous membrane", "soft palate organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005024" ; a owl:Class ; rdfs:label "mucosa of soft palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ] ) ] . obo:UBERON_0005025 obo:IAO_0000115 "A mucosa that is part of a uvula [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:60030" ; oboInOwl:hasExactSynonym "uvula mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005025" ; a owl:Class ; rdfs:label "mucosa of uvula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001734 ] ) ] . obo:UBERON_0005026 obo:IAO_0000115 "A mucosa that is part of a middle ear [Automatically generated definition]." ; oboInOwl:hasDbXref "CALOHA:TS-0631", "FMA:59663" ; oboInOwl:hasExactSynonym "middle ear mucosa", "middle ear mucosa of organ", "middle ear mucous membrane", "middle ear organ mucosa", "mucosa of organ of middle ear", "mucosa of tympanic cavity", "mucous membrane of middle ear", "organ mucosa of middle ear", "tunica mucosa cavitatis tympanicae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005026" ; a owl:Class ; rdfs:label "mucosa of middle ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] . obo:UBERON_0005027 obo:IAO_0000115 "A mucosa that is part of a frontal sinus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59774", "SCTID:368909005" ; oboInOwl:hasExactSynonym "frontal sinus mucosa", "frontal sinus mucosa of organ", "frontal sinus mucous membrane", "frontal sinus organ mucosa", "mucosa of organ of frontal sinus", "mucous membrane of frontal sinus", "organ mucosa of frontal sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005027" ; a owl:Class ; rdfs:label "mucosa of frontal sinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001760 ] ) ] . obo:UBERON_0005028 obo:IAO_0000115 "A mucosa that is part of a maxillary sinus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59773", "SCTID:368908002" ; oboInOwl:hasExactSynonym "antrum of highmore mucosa", "antrum of highmore mucosa of organ", "antrum of highmore mucous membrane", "antrum of highmore organ mucosa", "maxillary sinus mucosa", "maxillary sinus mucosa of organ", "maxillary sinus mucous membrane", "maxillary sinus organ mucosa", "mucosa of antrum of highmore", "mucosa of organ of antrum of highmore", "mucosa of organ of maxillary sinus", "mucous membrane of antrum of highmore", "mucous membrane of maxillary sinus", "organ mucosa of antrum of highmore", "organ mucosa of maxillary sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005028" ; a owl:Class ; rdfs:label "mucosa of maxillary sinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001764 ] ) ] . obo:UBERON_0005030 obo:IAO_0000115 "A mucosa that adjacent_to a paranasal sinus." ; oboInOwl:hasDbXref "FMA:59772" ; oboInOwl:hasExactSynonym "paranasal sinus mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005030" ; a owl:Class ; rdfs:label "mucosa of paranasal sinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001825 ] ) ] . obo:UBERON_0005031 obo:IAO_0000115 "A mucosa that is part of a upper lip [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59832", "NCIT:C12224", "SCTID:362088009", "UMLS:C0226933" ; oboInOwl:hasExactSynonym "mucosa of organ of upper lip", "mucous membrane of upper lip", "organ mucosa of upper lip", "upper labial mucosa", "upper lip mucosa", "upper lip mucosa of organ", "upper lip mucous membrane", "upper lip organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005031" ; a owl:Class ; rdfs:label "mucosa of upper lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0005032 obo:IAO_0000115 "A mucosa that is part of a lower lip [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59833", "NCIT:C12225", "SCTID:362089001", "UMLS:C0226939" ; oboInOwl:hasExactSynonym "lower labial mucosa", "lower lip mucosa", "lower lip mucosa of organ", "lower lip mucous membrane", "lower lip organ mucosa", "mucosa of organ of lower lip", "mucous membrane of lower lip", "organ mucosa of lower lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005032" ; a owl:Class ; rdfs:label "mucosa of lower lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] . obo:UBERON_0005033 obo:IAO_0000115 "A mucosa that is part of a gallbladder [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:14662", "SCTID:362196002" ; oboInOwl:hasExactSynonym "gall bladder mucosa", "gall bladder mucosa of organ", "gall bladder mucous membrane", "gall bladder organ mucosa", "gallbladder mucosa", "gallbladder mucosa of organ", "gallbladder mucous membrane", "gallbladder organ mucosa", "mucosa of gall bladder", "mucosa of organ of gall bladder", "mucosa of organ of gallbladder", "mucous membrane of gall bladder", "mucous membrane of gallbladder", "organ mucosa of gall bladder", "organ mucosa of gallbladder", "tunica mucosa (vesica biliaris)", "tunica mucosa vesicae biliaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005033" ; a owl:Class ; rdfs:label "mucosa of gallbladder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0005039 obo:IAO_0000115 "A mucosa that is part of a bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:62774", "SCTID:10887006" ; oboInOwl:hasExactSynonym "bronchiole mucosa", "bronchiole mucosa of organ", "bronchiole mucous membrane", "bronchiole organ mucosa", "mucosa of organ of bronchiole", "mucous membrane of bronchiole", "organ mucosa of bronchiole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005039" ; a owl:Class ; rdfs:label "mucosa of bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002186 ] ) ] . obo:UBERON_0005040 obo:IAO_0000115 "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:263232" ; oboInOwl:hasExactSynonym "bronchiolus terminalis mucosa", "bronchiolus terminalis mucosa of organ", "bronchiolus terminalis mucous membrane", "bronchiolus terminalis organ mucosa", "mucosa of bronchiolus terminalis", "mucosa of organ of bronchiolus terminalis", "mucosa of organ of terminal bronchiole", "mucous membrane of bronchiolus terminalis", "mucous membrane of terminal bronchiole", "organ mucosa of bronchiolus terminalis", "organ mucosa of terminal bronchiole", "terminal bronchiole mucosa", "terminal bronchiole mucosa of organ", "terminal bronchiole mucous membrane", "terminal bronchiole organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005040" ; a owl:Class ; rdfs:label "mucosa of terminal bronchiole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002187 ] ) ] . obo:UBERON_0005042 obo:IAO_0000115 "A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane." ; obo:UBPROP_0000012 "in FMA this is classified as a mucosa" ; oboInOwl:hasDbXref "FMA:56844", "SCTID:36411006" ; oboInOwl:hasExactSynonym "mucosa of tympanic membrane", "mucous layer of tympanic membrane", "mucous stratum of tympanic membrane", "tympanic membrane external middle ear cavity epithelial component", "tympanic membrane mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005042" ; a owl:Class ; rdfs:label "inner epithelial layer of tympanic membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009647 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010063 ] ) ] . obo:UBERON_0005043 obo:IAO_0000115 "A mucosa that is part of a nasolacrimal duct [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59664" ; oboInOwl:hasExactSynonym "mucosa of organ of nasolacrimal duct", "mucous membrane of nasolacrimal duct", "nasolacrimal duct mucosa", "nasolacrimal duct mucosa of organ", "nasolacrimal duct mucous membrane", "nasolacrimal duct organ mucosa", "nasolacrimal ductal mucosa", "organ mucosa of nasolacrimal duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005043" ; a owl:Class ; rdfs:label "mucosa of nasolacrimal duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002392 ] ) ] . obo:UBERON_0005044 obo:IAO_0000115 "A mucosa that is part of a pharyngotympanic tube [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:60109" ; oboInOwl:hasExactSynonym "auditory tube mucosa", "auditory tube mucosa of organ", "auditory tube mucous membrane", "auditory tube organ mucosa", "internal auditory tube mucosa", "internal auditory tube mucosa of organ", "internal auditory tube mucous membrane", "internal auditory tube organ mucosa", "mucosa of auditory tube", "mucosa of internal auditory tube", "mucosa of organ of auditory tube", "mucosa of organ of internal auditory tube", "mucosa of organ of pharyngotympanic tube", "mucous membrane of auditory tube", "mucous membrane of internal auditory tube", "mucous membrane of pharyngotympanic tube", "mucuous membrane of eustachian tube", "mucuous membrane of pharyngotympanic tube", "organ mucosa of auditory tube", "organ mucosa of internal auditory tube", "organ mucosa of pharyngotympanic tube", "pharyngotympanic tube mucosa", "pharyngotympanic tube mucosa of organ", "pharyngotympanic tube mucous membrane", "pharyngotympanic tube organ mucosa", "tunica mucosa (tuba auditiva)", "tunica mucosa (tuba auditoria)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005044" ; a owl:Class ; rdfs:label "mucosa of pharyngotympanic tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 ] ) ] . obo:UBERON_0005045 obo:IAO_0000115 "A mucosa that is part of a ethmoid sinus [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59776", "SCTID:65501003" ; oboInOwl:hasExactSynonym "ethmoid sinus mucosa", "ethmoid sinus mucosa of organ", "ethmoid sinus mucous membrane", "ethmoid sinus organ mucosa", "ethmoidal sinus mucosa", "mucosa of ethmoid sinus", "mucosa of organ of ethmoid sinus", "mucous membrane of ethmoid sinus", "organ mucosa of ethmoid sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005045" ; a owl:Class ; rdfs:label "mucosa of ethmoidal sinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002453 ] ) ] . obo:UBERON_0005046 obo:IAO_0000115 "A mucosa that is part of a hard palate [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:59783", "SCTID:245841005" ; oboInOwl:hasExactSynonym "hard palate mucosa", "hard palate mucous membrane", "mucous membrane of hard palate", "organ mucosa of hard palate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005046" ; a owl:Class ; rdfs:label "mucosa of hard palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003216 ] ) ] . obo:UBERON_0005047 obo:IAO_0000115 "A mucosa that is part of a vocal cord [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:64017" ; oboInOwl:hasExactSynonym "mucosa of glottis", "mucosa of organ of true vocal cord", "mucosa of organ of vocal cord", "mucosa of true vocal cord", "mucosa of vocal cord", "mucous membrane of true vocal cord", "mucous membrane of vocal cord", "organ mucosa of true vocal cord", "organ mucosa of vocal cord", "true vocal cord mucosa", "true vocal cord mucosa of organ", "true vocal cord mucous membrane", "true vocal cord organ mucosa", "vocal cord mucosa", "vocal cord mucosa of organ", "vocal cord mucous membrane", "vocal cord organ mucosa", "vocal fold mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005047" ; a owl:Class ; rdfs:label "mucosa of vocal fold" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid138186 ] . obo:UBERON_0005048 obo:IAO_0000115 "A mucosa that is part of a fallopian tube [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18319" ; oboInOwl:hasExactSynonym "fallopian tube mucosa", "fallopian tube mucosa of organ", "fallopian tube mucous membrane", "fallopian tube organ mucosa", "mucosa of fallopian tube", "mucosa of organ of fallopian tube", "mucosa of organ of uterine tube", "mucosa of oviduct", "mucous membrane of fallopian tube", "mucous membrane of uterine tube", "organ mucosa of fallopian tube", "organ mucosa of uterine tube", "tunica mucosa tubae uterinae", "uterine tubal mucosa", "uterine tube mucosa", "uterine tube mucosa of organ", "uterine tube mucous membrane", "uterine tube organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005048" ; a owl:Class ; rdfs:label "mucosa of uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 _:genid138210 ) ] . obo:UBERON_0005049 obo:IAO_0000115 "A mucosa that is part of a uterine tube infundibulum [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:18357" ; oboInOwl:hasExactSynonym "mucosa of infundibulum of fallopian tube", "mucosa of infundibulum of oviduct", "mucosa of organ of uterine tube infundibulum", "mucosa of uterine tube infundibulum", "mucous membrane of uterine tube infundibulum", "organ mucosa of uterine tube infundibulum", "uterine tube infundibulum mucosa", "uterine tube infundibulum mucosa of organ", "uterine tube infundibulum mucous membrane", "uterine tube infundibulum organ mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005049" ; a owl:Class ; rdfs:label "mucosa of infundibulum of uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003984 ] ) ] . obo:UBERON_0005051 obo:IAO_0000115 "The mediastinum testis is a network of fibrous connective tissue that extends from the upper to near the lower extremity of the testis, and is wider above than below. From its front and sides numerous imperfect septa (trabeculæ) are given off, which radiate toward the surface of the organ, and are attached to the tunica albuginea. They divide the interior of the organ into a number of incomplete spaces, called lobules. These are somewhat cone-shaped, being broad at their bases at the surface of the gland, and becoming narrower as they converge to the mediastinum. The mediastinum supports the rete testis and blood vessels of the testis in their passage to and from the substance of the gland[WP]." ; oboInOwl:hasDbXref "EMAPA:18331", "FMA:19812", "MA:0003240", "SCTID:362279007", "Wikipedia:Mediastinum_testis" ; oboInOwl:hasExactSynonym "body of highmore", "hilum of testicle", "mediastinum of testis", "testis mediastinum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005051" ; a owl:Class ; rdfs:label "mediastinum testis" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003728 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg"^^xsd:anyURI . obo:UBERON_0005055 obo:IAO_0000115 "An organ part that is part of a long bone [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:24008" ; oboInOwl:hasExactSynonym "long bone zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005055" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "zone of long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] . obo:UBERON_0005056 obo:IAO_0000115 "An external genitalia that is part of a female reproductive system [Automatically generated definition]." ; obo:UBPROP_0000008 "in eutherians, this is known as the vulva in and composed of the mons pubis, the labia majora and minora, the clitoris, the vestibule of the vagina and its glands, and the opening of the urethra and of the vagina [MP:0003126]" ; oboInOwl:hasDbXref "BTO:0003100", "EMAPA:30984", "FMA:45649", "SCTID:362234008", "galen:FemaleExternalGenitalia" ; oboInOwl:hasExactSynonym "external female genital organ", "external genitalia of female reproductive system", "female external genitalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organa genitalia feminina externa" ; oboInOwl:id "UBERON:0005056" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ; rdfs:label "external female genitalia" ; owl:disjointWith obo:UBERON_0009196 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004176 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0005057 obo:IAO_0000115 "An organ that is part of a immune system [Automatically generated definition]." ; oboInOwl:hasExactSynonym "immune system organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005057" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "immune organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 ] ) ] . obo:UBERON_0005058 obo:IAO_0000115 "A gland that is part of a hemolymphoid system [Automatically generated definition]." ; oboInOwl:hasBroadSynonym "hemopoietic or lymphoid organ" ; oboInOwl:hasDbXref "EMAPA:18766", "MA:0002962" ; oboInOwl:hasExactSynonym "hemopoietic or lymphoid gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "haemolymphoid system gland" ; oboInOwl:id "UBERON:0005058" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "hemolymphoid system gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002193 ] ) ] . obo:UBERON_0005061 obo:IAO_0000115 "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." ; obo:UBPROP_0000001 "The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]." ; oboInOwl:hasDbXref "AAO:0011071", "EMAPA:35594", "FMA:295624", "NCIT:C34224", "SCTID:361463007", "UMLS:C0814992", "Wikipedia:Neural_groove", "XAO:0000248", "neuronames:1363" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005061" ; a owl:Class ; rdfs:label "neural groove" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003075 ] . obo:UBERON_0005062 obo:IAO_0000115 "One of the two elevated edges of the neural groove[GO,MP]." ; obo:UBPROP_0000001 "In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]." ; oboInOwl:hasDbXref "EHDAA2:0001249", "FMA:295618", "NCIT:C34223", "SCTID:361461009", "UMLS:C0814993", "Wikipedia:Neural_fold", "XAO:0004087", "neuronames:1364" ; oboInOwl:hasExactSynonym "medullary fold" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005062" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neural fold" ; rdfs:subClassOf obo:UBERON_0005157, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005061 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0005061 ] . obo:UBERON_0005064 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005064" ; a owl:Class ; rdfs:label "left ventricular trabecular myocardium" ; rdfs:subClassOf _:genid139575 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0005066 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005066" ; a owl:Class ; rdfs:label "right ventricular trabecular myocardium" ; rdfs:subClassOf _:genid139582 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004126 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0005068 obo:IAO_0000115 "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." ; obo:UBPROP_0000001 "An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO]" ; oboInOwl:hasDbXref "EFO:0003498", "TAO:0000133", "ZFA:0000133" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural tube rod" ; oboInOwl:id "UBERON:0005068" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "neural rod" ; rdfs:subClassOf obo:UBERON_0016879, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007135 ] . obo:UBERON_0005075 obo:IAO_0000115 "An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain." ; obo:UBPROP_0000001 "The boundary between the diencephalon and the mesencephalon.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from forebrain midbrain boundary neural tube (TAO:0007040)[TAO]" ; oboInOwl:hasDbXref "EMAPA:36449", "TAO:0001367", "ZFA:0001367" ; oboInOwl:hasExactSynonym "diencephalic-mesencephalic boundary", "forebrain midbrain boundary", "forebrain-midbrain boundary region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005075" ; a owl:Class ; rdfs:label "forebrain-midbrain boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], _:genid139597 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001890 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0005076 obo:IAO_0000115 "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord." ; oboInOwl:hasExactSynonym "hindbrain-spinal cord boundary region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005076" ; a owl:Class ; rdfs:label "hindbrain-spinal cord boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002028 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0005080 obo:IAO_0000115 "The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005080" ; a owl:Class ; rdfs:label "metanephric ureteric bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005081 obo:IAO_0000115 "The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005081" ; a owl:Class ; rdfs:label "ureter ureteric bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000084 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0005082 obo:IAO_0000115 "A hole in a tube[GO]." ; oboInOwl:hasDbXref "AEO:0000078", "EHDAA2:0004618", "RETIRED_EHDAA2:0003078" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005082" ; a owl:Class ; rdfs:label "tube lumen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid138341 ] . obo:UBERON_0005085 obo:IAO_0000115 "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]." ; obo:IAO_0000116 "consder adding placodal ectoderm as a distinct class? Also place placodal ectoderm as develops_from ectoderm; need to check taxon-appropriateness" ; obo:UBPROP_0000008 "With the exception of the adenohypophysis, homologues of the nonneurogenic placodes (e.g. placodes giving rise to the teeth, hair follicles and lens), appear to be lacking in invertebrate chordates." ; obo:UBPROP_0000012 "in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures" ; oboInOwl:hasDbXref "AEO:0000218" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelial placode" ; oboInOwl:id "UBERON:0005085" ; a owl:Class ; rdfs:label "ectodermal placode" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ] . obo:UBERON_0005086 obo:IAO_0000115 "A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate." ; obo:UBPROP_0000001 "An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud[GO]." ; oboInOwl:hasDbXref "EMAPA:36479" ; oboInOwl:hasExactSynonym "hair placode" ; oboInOwl:hasNarrowSynonym "vibrissa placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hair gem", "hair germ", "hair peg" ; oboInOwl:id "UBERON:0005086" ; a owl:Class ; rdfs:label "hair follicle placode" ; rdfs:subClassOf obo:UBERON_0011817, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001003 ], _:genid139637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002073 ] ) ] . obo:UBERON_0005087 obo:IAO_0000115 "An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO]." ; obo:UBPROP_0000001 "Placode that develops into a tooth. The placode is a thickening of the pharyngeal epithelium.[TAO]" ; obo:UBPROP_0000015 "In mammals this may be located in the alveolar ridges, but note that some species such as zebrafish have ceratobranchial teeth. Sharks have dermal denticles that share developmental origins. Currently we don't include location information due to this diversity, but in future we may include specific subclasses and/or taxon GCIs." ; oboInOwl:hasDbXref "BTO:0001511", "TAO:0001153", "ZFA:0001153" ; oboInOwl:hasExactSynonym "dental anlage", "dental placode", "dental primordium", "odontogenic placode", "tooth anlage", "tooth primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tooth germ" ; oboInOwl:id "UBERON:0005087" ; a owl:Class ; rdfs:label "tooth placode" ; rdfs:subClassOf obo:UBERON_0011814, _:genid139650 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001091 ] ) ] . obo:UBERON_0005088 obo:IAO_0000115 "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." ; obo:IAO_0000116 "TODO - add bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005088" ; a owl:Class ; rdfs:label "sebaceous gland placode" ; rdfs:subClassOf obo:UBERON_0011814, _:genid139665 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:UBERON_0005089 obo:IAO_0000115 "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." ; obo:IAO_0000116 "TODO - add bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005089" ; a owl:Class ; rdfs:label "sweat gland placode" ; rdfs:subClassOf obo:UBERON_0011814, _:genid139673 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001820 ] ) ] . obo:UBERON_0005090 obo:IAO_0000115 "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." ; obo:IAO_0000232 "in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila" ; oboInOwl:hasDbXref "EMAPA:32715", "FMA:30316" ; oboInOwl:hasExactSynonym "musculus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle", "muscle element" ; oboInOwl:id "UBERON:0005090" ; a owl:Class ; rdfs:label "muscle structure" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000187 ] . obo:UBERON_0005092 obo:UBPROP_0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001841", "EHDAA:484", "EMAPA:16239", "FMA:70318", "VHOG:0000489" ; oboInOwl:hasExactSynonym "sinus venosus right horn" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005092" ; a owl:Class ; rdfs:label "right horn of sinus venosus" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0002063 ] . obo:UBERON_0005095 obo:IAO_0000115 "." ; obo:IAO_0000116 "class added for consistency with GO - consider merging with kidney mesenchyme." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney anlage" ; oboInOwl:id "UBERON:0005095" ; a owl:Class ; rdfs:label "kidney rudiment" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid139684 . obo:UBERON_0005103 obo:IAO_0000115 "An epithelium that is part of a mesonephros [Automatically generated definition]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005103" ; a owl:Class ; rdfs:label "mesonephric epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005106 obo:IAO_0000115 "A metanephric tubule is an epithelial tube that is part of the metanephros[GO]." ; obo:UBPROP_0000003 "The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes.[well established][VHOG]" ; oboInOwl:hasDbXref "VHOG:0001526" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005106" ; a owl:Class ; rdfs:label "metanephric tubule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005108 obo:IAO_0000115 "An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005108" ; a owl:Class ; rdfs:label "metanephric epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005109 obo:IAO_0000115 "Any smooth muscle tissue that is part of a metanephros." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005109" ; a owl:Class ; rdfs:label "metanephric smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005110 obo:IAO_0000115 "A metanephric nephron is the functional unit of the metanephros[GO]." ; obo:UBPROP_0000003 "The primitive form of the vertebrate nephron consists of a vascular filtration surface overlain with podocytes, a specialized coelomic cavity to receive the ultrafiltrate, and a tubule for modification to final urine. Although previously thought to be unique to the vertebrates, this design is now known to be widespread among invertebrates, including most of the protochordates, and especially their larvae.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0005142" ; oboInOwl:hasDbXref "VHOG:0000719" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005110" ; a owl:Class ; rdfs:label "metanephric nephron" ; rdfs:subClassOf _:genid139713, _:genid139715 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005111 obo:IAO_0000115 "Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005111" ; a owl:Class ; rdfs:label "metanephric pyramid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004200 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005113 oboInOwl:hasDbXref "EHDAA2:0001140" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005113" ; a owl:Class ; rdfs:label "metanephric cortex mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid139724 . obo:UBERON_0005115 obo:IAO_0000115 "The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005115" ; a owl:Class ; rdfs:label "metanephric cortical collecting duct" ; rdfs:subClassOf _:genid139730, _:genid139732 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004203 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005133 obo:IAO_0000115 "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO]." ; oboInOwl:hasAlternativeId "UBERON:0005143" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005133" ; a owl:Class ; rdfs:label "metanephric glomerulus vasculature" ; rdfs:subClassOf _:genid139739 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005134 obo:IAO_0000115 "The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005134" ; a owl:Class ; rdfs:label "metanephric nephron epithelium" ; rdfs:subClassOf _:genid139746 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005135 obo:IAO_0000115 "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005135" ; a owl:Class ; rdfs:label "metanephric glomerular epithelium" ; rdfs:subClassOf _:genid139753, _:genid139755 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004188 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005136 obo:IAO_0000115 "The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005136" ; a owl:Class ; rdfs:label "metanephric glomerular endothelium" ; rdfs:subClassOf _:genid139762, _:genid139764, _:genid139766 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004189 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005137 obo:IAO_0000115 "The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO]." ; oboInOwl:hasAlternativeId "UBERON:0005112" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005137" ; a owl:Class ; rdfs:label "metanephric capsule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005144 obo:IAO_0000115 "This process pertains to the initial formation of a structure from unspecified parts[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005144" ; a owl:Class ; rdfs:label "metanephric glomerular capillary" ; rdfs:subClassOf _:genid139778, _:genid139780 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004212 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005145 obo:IAO_0000115 "The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005145" ; a owl:Class ; rdfs:label "metanephric comma-shaped body" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004198 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005146 obo:IAO_0000115 "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO]." ; oboInOwl:hasAlternativeId "UBERON:0005128", "UBERON:0005152" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005146" ; a owl:Class ; rdfs:label "metanephric nephron tubule" ; rdfs:subClassOf _:genid139792, _:genid139794 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001231 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005147 obo:IAO_0000115 "The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." ; oboInOwl:hasDbXref "EHDAA2:0001245", "EHDAA:9346", "EMAPA:27678" ; oboInOwl:hasExactSynonym "metanephric vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005147" ; a owl:Class ; rdfs:label "metanephric renal vesicle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005134 ], _:genid139801 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005148 obo:IAO_0000115 "The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005148" ; a owl:Class ; rdfs:label "metanephric S-shaped body" ; rdfs:subClassOf _:genid139809 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004199 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005153 obo:IAO_0000115 "A bud is a protrusion that forms from an epithelial sheet by localized folding." ; oboInOwl:hasDbXref "BTO:0001639" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005153" ; a owl:Class ; rdfs:label "epithelial bud" ; rdfs:subClassOf obo:UBERON_0005157 . obo:UBERON_0005154 obo:IAO_0000115 "A cord of epithelial cells without a lumen and usually several cells thick." ; oboInOwl:hasDbXref "AEO:0000216", "EHDAA2:0004052" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005154" ; a owl:Class ; rdfs:label "epithelial cord" ; rdfs:subClassOf obo:UBERON_0000486 . obo:UBERON_0005156 obo:IAO_0000115 "Any anatomical structure that is part of the reproductive system." ; oboInOwl:hasExactSynonym "reproductive system element", "reproductive system structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005156" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "reproductive structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ] ) ] . obo:UBERON_0005157 obo:IAO_0000115 "An epithelial sheet bent on a linear axis." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005157" ; a owl:Class ; rdfs:label "epithelial fold" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0005158 obo:IAO_0000115 "The functional tissue of the central nervous system consisting of neurons and glial cells." ; oboInOwl:hasExactSynonym "CNS parenchyma", "central nervous system parenchyma", "parenchyma of CNS", "parenchyma of central nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005158" ; a owl:Class ; rdfs:label "parenchyma of central nervous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0005162 obo:IAO_0000115 "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." ; obo:UBPROP_0000012 "we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'" ; oboInOwl:hasDbXref "AAO:0011000", "CARO:0001000", "FBbt:00007060", "FMA:83115" ; oboInOwl:hasExactSynonym "multi-cell-component structure", "multi-cell-part structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cell part cluster" ; oboInOwl:id "UBERON:0005162" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "multi cell part structure" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0005575 ] . obo:UBERON_0005169 obo:IAO_0000115 "Connective tissue between the cellular elements of a structure." ; obo:IAO_0000116 "specify differentia from stroma" ; obo:UBPROP_0000007 "interstital" ; oboInOwl:hasDbXref "FMA:86301", "SCTID:85293002" ; oboInOwl:hasExactSynonym "interstitium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005169" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "interstitial tissue" ; rdfs:subClassOf obo:UBERON_0003891 . obo:UBERON_0005171 obo:IAO_0000115 "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." ; obo:IAO_0000116 "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same" ; obo:UBPROP_0000001 "A duct that carries bile from the liver to the small intestine.[TAO]", "The excretory duct of the liver or one of its branches in the lobes of the liver. [TFD][VHOG]", "The hepatic duct is the duct that leads from the liver to the bile duct[GO]." ; oboInOwl:hasDbXref "EHDAA2:0000741", "EHDAA:3049", "EMAPA:16843", "FMA:71891", "MA:0000357", "NCIT:C32730", "SCTID:245399002", "UMLS:C0917710", "VHOG:0000219", "galen:HepaticDuct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005171" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "hepatic duct" ; rdfs:subClassOf obo:UBERON_0002394, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001174 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002107 ] . obo:UBERON_0005172 obo:IAO_0000115 "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." ; oboInOwl:hasDbXref "MA:0000522", "SCTID:272631008" ; oboInOwl:hasExactSynonym "abdomen organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005172" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "abdomen element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0005173 obo:IAO_0000115 "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." ; oboInOwl:hasDbXref "EMAPA:37062", "MA:0000529" ; oboInOwl:hasExactSynonym "abdominal segment organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005173" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "abdominal segment element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0005174 obo:IAO_0000115 "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." ; oboInOwl:hasDbXref "EMAPA:37274", "MA:0001901" ; oboInOwl:hasExactSynonym "back organ", "dorsal region organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005174" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "dorsal region element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0005175 obo:IAO_0000115 "An organ that is part of a chest [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37272", "MA:0000552" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005175" ; oboInOwl:inSubset core:non_informative, core:organ_slim ; a owl:Class ; rdfs:label "chest organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0005176 obo:IAO_0000115 "A circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth." ; obo:UBPROP_0000001 "A structure that is involved in tooth formation. A bell shape two layer epithelial structure that descends toward the ceratobranchial 5 bone, enclosing the dental mesenchyme. At later times in tooth development the cells at the apex of the bell may be involved in enameloid formation. This structure remains at the base of the erupted tooth and is the source of replacement teeth.[TAO]" ; obo:UBPROP_0000011 "NOT develops_from NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]" ; obo:UBPROP_0000013 "Historically, enamel organ has been the term to describe this structure, but it was attempted unsuccessfully in recent years to change the name to dental organ in order to better represent its multiple functions apart from enamel formation" ; oboInOwl:hasDbXref "BTO:0001722", "CALOHA:TS-0271", "EMAPA:32888", "FMA:312389", "MA:0001604", "MESH:D004658", "SCTID:362863002", "TAO:0005138", "Wikipedia:Enamel_organ", "ZFA:0005138" ; oboInOwl:hasExactSynonym "dental organ", "enamel organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "odontogenic organ", "organum enameleum" ; oboInOwl:id "UBERON:0005176" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment ". Alternate definition: A cellular aggregation seen in histologic sections of a developing tooth. It lies above a condensation of ectomesenchymal cells called the odontogenic papilla." ; rdfs:label "tooth enamel organ" ; rdfs:subClassOf obo:UBERON_0034922, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008281 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] . obo:UBERON_0005177 obo:IAO_0000115 "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." ; oboInOwl:hasDbXref "EMAPA:37270", "MA:0000516" ; oboInOwl:hasExactSynonym "trunk organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005177" ; oboInOwl:inSubset core:non_informative, core:organ_slim ; a owl:Class ; rdfs:label "trunk region element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0005178 obo:IAO_0000115 "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." ; oboInOwl:hasDbXref "EMAPA:37273", "MA:0000557" ; oboInOwl:hasExactSynonym "thoracic cavity organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005178" ; oboInOwl:inSubset core:non_informative, core:pheno_slim ; a owl:Class ; rdfs:label "thoracic cavity element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 ] ) ] . obo:UBERON_0005179 obo:IAO_0000115 "An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis." ; oboInOwl:hasDbXref "EMAPA:37275", "MA:0000543" ; oboInOwl:hasExactSynonym "pelvic element", "pelvis organ", "pelvis region organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005179" ; oboInOwl:inSubset core:non_informative, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "pelvic region element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0005181 obo:IAO_0000115 "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." ; oboInOwl:hasDbXref "EMAPA:37271", "MA:0000563" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper body organ" ; oboInOwl:id "UBERON:0005181" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "thoracic segment organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0005184 obo:IAO_0000115 "Innermost layer of the hair shaft." ; oboInOwl:hasDbXref "BTO:0004671", "EMAPA:35389", "MA:0000158", "SCTID:318929009", "Wikipedia:Bone_marrow_of_ovary_(hair)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medulla of hair shaft" ; oboInOwl:id "UBERON:0005184" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hair medulla" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] . obo:UBERON_0005185 obo:IAO_0000115 "The portion of the collecting duct that resides in the renal medulla." ; oboInOwl:hasDbXref "BTO:0004536", "EMAPA:28061", "EMAPA:35459", "MA:0002935" ; oboInOwl:hasExactSynonym "kidney medulla collecting duct", "medullary collecting duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005185" ; a owl:Class ; rdfs:label "renal medulla collecting duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:UBERON_0005192 obo:IAO_0000115 "An artery in males that provides blood to the vas deferens. The artery usually arises from the anterior trunk of the superior vesical artery. It accompanies the vas deferens into the testis, where it anastomoses with the testicular artery. In this way it also supplies blood to the testis and epididymis. A small branch supplies the ureter[WP]." ; oboInOwl:hasDbXref "EMAPA:37513", "FMA:18930", "MA:0001940", "SCTID:279659005", "Wikipedia:Artery_to_the_ductus_deferens" ; oboInOwl:hasExactSynonym "arteria ductus deferentis", "artery of ductus deferens", "ductus deferens artery", "vas deferens artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005192" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "deferent duct artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005352 ], _:genid139929, _:genid139931 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ] . obo:UBERON_0005193 obo:IAO_0000115 "One of: anterior or posterior ethmoidal arteries." ; oboInOwl:hasDbXref "EMAPA:37081", "MA:0001949", "NCIT:C52855", "SCTID:244222007", "UMLS:C0226184", "Wikipedia:Ethmoidal_arteries" ; oboInOwl:hasExactSynonym "ethmoid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005193" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "ethmoidal artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid139943 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0012318 obo:UBERON_0012319 ) ] . obo:UBERON_0005194 obo:IAO_0000115 "A vein that is part of a thorax [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37197", "MA:0002235", "NCIT:C53142", "SCTID:281472008", "UMLS:C0226629" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005194" ; a owl:Class ; rdfs:label "thoracic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0005195 obo:IAO_0000115 "A vein that is part of a vas deferens [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:37514", "MA:0002100" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005195" ; a owl:Class ; rdfs:label "deferent duct vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ] . obo:UBERON_0005196 obo:IAO_0000115 "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." ; oboInOwl:hasDbXref "EMAPA:35803", "MA:0000764", "NCIT:C49760", "UMLS:C1710156" ; oboInOwl:hasExactSynonym "germinal center of spleen", "spleen GC", "spleen follicle center", "splenic germinal center" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005196" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen germinal center" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004042 ], _:genid139965 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0005199 obo:IAO_0000115 "A mammary gland that is part of a cervical region." ; obo:UBPROP_0000008 "mice have a single pair of cervical mammary glands" ; oboInOwl:hasDbXref "MA:0000789" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005199" ; a owl:Class ; rdfs:label "cervical mammary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005434 ] ) ] . obo:UBERON_0005200 obo:IAO_0000115 "A lactiferous gland that is located in the thoracic region/breast." ; obo:UBPROP_0000008 "Most primates have one pair of mammary glands, which are thoracic." ; obo:UBPROP_0000202 obo:FMA_57983 ; oboInOwl:hasBroadSynonym "lactiferous gland", "mammary gland" ; oboInOwl:hasDbXref "EHDAA2:0001056", "EHDAA:6524", "EMAPA:36633", "FMA:62088", "MA:0000797", "SCTID:31448001", "Wikipedia:Mammary_gland#Other_mammals" ; oboInOwl:hasExactSynonym "breast mammary gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior mammary gland" ; oboInOwl:id "UBERON:0005200" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "thoracic mammary gland" ; rdfs:subClassOf _:genid139982 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0005203 obo:IAO_0000115 "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." ; obo:UBPROP_0000009 "These glands secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents." ; oboInOwl:hasDbXref "EMAPA:36574", "FMA:7473", "MA:0002937", "SCTID:197423006" ; oboInOwl:hasExactSynonym "glandula trachealis", "tracheal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tubular seromucous gland of trachea" ; oboInOwl:id "UBERON:0005203" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "trachea gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000159 ] ) ] . obo:UBERON_0005204 obo:IAO_0000115 "A gland that is part of a larynx submucosa [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35475", "MA:0002729" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "laryngeal submucosa gland" ; oboInOwl:id "UBERON:0005204" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "larynx submucosa gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004778 ] ) ] . obo:UBERON_0005205 oboInOwl:hasDbXref "EMAPA:35902", "FMA:19979", "MA:0002737" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vagina stroma" ; oboInOwl:id "UBERON:0005205" ; a owl:Class ; rdfs:label "lamina propria of vagina" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0005206 obo:IAO_0000115 "Stromal matrix surrounding blood vessels within the choroid plexus." ; oboInOwl:hasDbXref "EMAPA:36609", "MA:0000825" ; oboInOwl:hasExactSynonym "choroid plexus stromal matrix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005206" ; a owl:Class ; rdfs:label "choroid plexus stroma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000235 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:UBERON_0005207 obo:IAO_0000115 "A capsule that is part of a tonsil [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:294647", "MA:0000776" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005207" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tonsil capsule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:UBERON_0005208 obo:IAO_0000115 "A valve that is part of a right atrium [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000302", "EMAPA:17327", "MA:0001871" ; oboInOwl:hasExactSynonym "valve of right atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right atrium valves", "superior vena cava valve" ; oboInOwl:id "UBERON:0005208" ; a owl:Class ; rdfs:label "right atrium valve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003978 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ] ) ] . obo:UBERON_0005211 obo:IAO_0000115 "Tissue surrounding the loop of Henle in the renal medulla." ; obo:UBPROP_0000009 "It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system. This hypertonicity, in turn, is created by an efflux of urea from the inner medullary collecting duct." ; oboInOwl:hasDbXref "EMAPA:18326", "MA:0002619", "SCTID:245693005", "Wikipedia:Bone_marrow_of_ovaryry_interstitium" ; oboInOwl:hasExactSynonym "kidney medulla interstitium", "renal medullary interstitial tissue", "renal medullary interstitium" ; oboInOwl:hasNarrowSynonym "medullary interstitium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medullary stroma" ; oboInOwl:id "UBERON:0005211" ; a owl:Class ; rdfs:label "renal medulla interstitium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0070295 ], _:genid140034 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005169 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000362 ] ) ] . obo:UBERON_0005212 obo:IAO_0000115 "The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.." ; oboInOwl:hasDbXref "EMAPA:18687", "MA:0002713", "SCTID:362280005" ; oboInOwl:hasExactSynonym "interstitium of testis", "interstitium of the testis", "testis - interstitial", "testis interstitial tissue", "testis interstitium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005212" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "Leydig cell region of testis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005169 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000178 ] ) ] . obo:UBERON_0005214 obo:IAO_0000115 "A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:28364", "MA:0002620" ; oboInOwl:hasExactSynonym "inner medullary interstitium", "kidney inner medulla interstitium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "papillary interstitium" ; oboInOwl:id "UBERON:0005214" ; a owl:Class ; rdfs:label "inner renal medulla interstitium" ; rdfs:subClassOf _:genid140059, _:genid140061 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005169 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 ] ) ] . obo:UBERON_0005215 obo:IAO_0000115 "The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes." ; obo:IAO_0000116 "See https://sourceforge.net/p/geneontology/ontology-requests/10941/" ; obo:UBPROP_0000009 "The interstitium is necessarily involved in all intrarenal exchange processes since the reabsorption and secretion of fluid and solutes implicates a transit across the interstitial compartment." ; obo:UBPROP_0000010 "The fibroblasts in the interstitium provide the 'skeleton' of the tissue and maintain the three-dimensional architecture of the tissue." ; oboInOwl:hasDbXref "EMAPA:28518", "FMA:70983", "MA:0002616", "NCIT:C33459", "SCTID:362210003" ; oboInOwl:hasExactSynonym "interstitial tissue of kidney", "renal interstitial tissue", "renal interstitium", "renal stroma", "stroma of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney interstitium group" ; oboInOwl:id "UBERON:0005215" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "kidney interstitium" ; rdfs:subClassOf obo:UBERON_0003891, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_1000692 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005169 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0005216 obo:IAO_0000115 "An external ectoderm that is part of a optic eminence [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:16539", "RETIRED_EHDAA2:0001311", "VHOG:0000520" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005216" ; a owl:Class ; rdfs:label "optic eminence surface ectoderm" ; rdfs:subClassOf _:genid140083 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000076 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004348 ] ) ] . obo:UBERON_0005217 obo:IAO_0000115 "A subarachnoid space that is part of a midbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Subarachnoid space that is part of the midbrain. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EMAPA:19055", "VHOG:0001304" ; oboInOwl:hasExactSynonym "subarachnoid space midbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subarachnoid space mesencephalon" ; oboInOwl:id "UBERON:0005217" ; a owl:Class ; rdfs:label "midbrain subarachnoid space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0005218 obo:IAO_0000115 "A subarachnoid space that is part of a diencephalon [Automatically generated definition]." ; obo:UBPROP_0000001 "Subarachnoid space that is part of the diencephalon. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EMAPA:19053", "VHOG:0001302" ; oboInOwl:hasExactSynonym "subarachnoid space diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005218" ; a owl:Class ; rdfs:label "diencephalon subarachnoid space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0005219 obo:IAO_0000115 "A subarachnoid space that is part of a hindbrain [Automatically generated definition]." ; obo:UBPROP_0000001 "Subarachnoid space that is part of the hindbrain. [Bgee_curator][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18211", "VHOG:0001303" ; oboInOwl:hasExactSynonym "subarachnoid space hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subarachnoid space rhombencephalon" ; oboInOwl:id "UBERON:0005219" ; a owl:Class ; rdfs:label "hindbrain subarachnoid space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0005221 obo:IAO_0000115 "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001010", "EMAPA:18317", "FMA:71657", "VHOG:0000840" ; oboInOwl:hasExactSynonym "parenchyma of right lobe of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005221" ; a owl:Class ; rdfs:label "liver right lobe parenchyma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid138795 ] . obo:UBERON_0005222 obo:IAO_0000115 "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001002", "EMAPA:18310", "FMA:71658", "VHOG:0000839" ; oboInOwl:hasExactSynonym "parenchyma of left lobe of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005222" ; a owl:Class ; rdfs:label "liver left lobe parenchyma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001115 ] ) ] . obo:UBERON_0005225 obo:IAO_0000115 "An epithelium that is part of a hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002131", "EMAPA:17500", "VHOG:0001041" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005225" ; a owl:Class ; rdfs:label "upper leg epithelium" ; rdfs:subClassOf _:genid140125 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0005226 obo:IAO_0000115 "An epithelium that is part of a toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32946", "VHOG:0001031" ; oboInOwl:hasExactSynonym "hind limb digit epithelium", "toe epithelium" ; oboInOwl:hasNarrowSynonym "foot digit epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005226" ; a owl:Class ; rdfs:label "pedal digit epithelium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid140133 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0005227 obo:IAO_0000115 "An epithelium that is part of a finger [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0000406", "EMAPA:32647", "VHOG:0001032" ; oboInOwl:hasExactSynonym "finger epithelium", "fore limb digit epithelium" ; oboInOwl:hasNarrowSynonym "hand digit epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005227" ; a owl:Class ; rdfs:label "manual digit epithelium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid140142 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0005228 obo:IAO_0000115 "An epithelium that is part of a forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002113", "EMAPA:17425", "VHOG:0000990" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005228" ; a owl:Class ; rdfs:label "upper arm epithelium" ; rdfs:subClassOf _:genid140151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0005229 obo:IAO_0000115 "An epithelium that is part of a lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001031", "EMAPA:17497", "VHOG:0001050" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005229" ; a owl:Class ; rdfs:label "lower leg epithelium" ; rdfs:subClassOf _:genid140158 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0005233 obo:IAO_0000115 "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001078", "EMAPA:16809", "FMA:312675", "VHOG:0000803" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005233" ; a owl:Class ; rdfs:label "medial-nasal process ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, _:genid140166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004068 ] ) ] . obo:UBERON_0005234 obo:IAO_0000115 "An ectoderm that is part of a optic eminence [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA:940", "EMAPA:16539", "RETIRED_EHDAA2:0001309", "VHOG:0001105" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005234" ; a owl:Class ; rdfs:label "optic eminence ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004348 ] ) ] . obo:UBERON_0005236 obo:IAO_0000115 "A small, oval, bony chamber of the labyrinth. The vestibule contains the utricle and saccule, organs which are part of the balancing apparatus of the ear." ; obo:UBPROP_0000001 "The vestibule is the central part of the osseous labyrinth, and is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals. [Wikipedia:Vestibule_of_the_ear][VHOG]" ; oboInOwl:hasBroadSynonym "vestibule" ; oboInOwl:hasDbXref "BTO:0003382", "CALOHA:TS-0479", "EV:0100366", "FMA:60183", "GAID:881", "MA:0001185", "MESH:D014722", "NCIT:C33873", "SCTID:181188003", "UMLS:C0458718", "VHOG:0001220", "Wikipedia:Vestibule_of_the_ear", "XAO:0000199" ; oboInOwl:hasExactSynonym "bony labyrinth vestibule", "inner ear vestibulum", "osseous labyrinth vestibule", "vestibule of bony labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inner ear vestibule", "vestibular apparatus", "vestibular part of bony labyrinth", "vestibulum auris", "vestibulum labyrinthi" ; oboInOwl:id "UBERON:0005236" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "osseus labyrinth vestibule" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001839 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001846 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray919.png"^^xsd:anyURI . obo:UBERON_0005239 obo:UBPROP_0000001 "The ventral half of the developing neural tube that is the metencephalon. [Chordate_evolution_and_the_origin_of_craniates:_An_old_brain_in_a_new_head._AnaT_Rec_(New_Anat)_(2000)_261(3):_111-125, See_Butler_AB][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001154", "EMAPA:17078", "VHOG:0000320" ; oboInOwl:hasExactSynonym "metencephalon basal plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005239" ; a owl:Class ; rdfs:label "basal plate metencephalon" ; rdfs:subClassOf obo:UBERON_0004064 . obo:UBERON_0005243 obo:IAO_0000115 "An endocardium that is part of a interventricular septum [Automatically generated definition]." ; obo:IAO_0000116 "TODO - split?" ; oboInOwl:hasDbXref "EHDAA2:0000886", "EHDAA2:0000887", "FMA:83584", "VHOG:0000615" ; oboInOwl:hasExactSynonym "endocardium of interventricular septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interventricular septum endocardial tissue" ; oboInOwl:id "UBERON:0005243" ; a owl:Class ; rdfs:label "interventricular septum endocardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002094 ] ) ] . obo:UBERON_0005248 obo:IAO_0000115 "A myocardium that is part of a bulbus cordis [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:36488", "VHOG:0000609" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bulbus cordis cardiac muscle" ; oboInOwl:id "UBERON:0005248" ; a owl:Class ; rdfs:label "bulbus cordis myocardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004706 ] ) ] . obo:UBERON_0005249 obo:IAO_0000115 "A renal pelvis that is part of a metanephros." ; obo:UBPROP_0000003 "The ureteric bud itself forms the collecting tubules and the ureter that drain the adult kidney. This type of kidney, called the metanephros, occurs in all adult amniotes.[well established][VHOG]" ; oboInOwl:hasDbXref "VHOG:0000945" ; oboInOwl:hasExactSynonym "metanephros pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005249" ; a owl:Class ; rdfs:label "metanephric renal pelvis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001224 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ] . obo:UBERON_0005250 obo:IAO_0000115 "A gland that is part of a stomodeum." ; obo:IAO_0000116 "check this" ; oboInOwl:hasDbXref "VHOG:0000658" ; oboInOwl:hasExactSynonym "stomatodaeum gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005250" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "stomatodeum gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000930 ] ) ] . obo:UBERON_0005251 obo:IAO_0000115 "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." ; obo:UBPROP_0000008 "In mammals, the yolk sac cavity contains fluid rather than platelets" ; obo:UBPROP_0000012 "in EHDAA2, there are separate primary and secondary yolk sac cavities" ; oboInOwl:hasDbXref "EMAPA:16055", "FMA:63942", "VHOG:0000843" ; oboInOwl:hasExactSynonym "cavity of yolk sac", "yolk sac lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "yolk sac space" ; oboInOwl:id "UBERON:0005251" ; a owl:Class ; rdfs:label "yolk sac cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] . obo:UBERON_0005253 obo:IAO_0000115 "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." ; obo:UBPROP_0000001 "Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO]" ; oboInOwl:hasDbXref "EFO:0003492", "EHDAA2:0000732", "EHDAA:179", "EMAPA:16098", "EMAPA_RETIRED:16269", "FMA:76622", "TAO:0000113", "VHOG:0000332", "ZFA:0000113" ; oboInOwl:hasExactSynonym "cephalic mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial mesenchyme", "desmocranium" ; oboInOwl:id "UBERON:0005253" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "head mesenchyme" ; rdfs:subClassOf _:genid140229 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0005254 obo:IAO_0000115 "Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002132", "EMAPA:17501", "VHOG:0000506" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005254" ; a owl:Class ; rdfs:label "upper leg mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0005255 obo:IAO_0000115 "Mesenchyme that is part of a developing toe [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32947", "VHOG:0000463" ; oboInOwl:hasExactSynonym "hind limb digit mesenchyme", "toe mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "finger ray mesenchyme", "pedal digital ray mesenchyme" ; oboInOwl:id "UBERON:0005255" ; a owl:Class ; rdfs:label "pedal digit mesenchyme" ; rdfs:subClassOf _:genid140245 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0005256 obo:IAO_0000115 "Mesenchyme that is part of a developing trunk." ; oboInOwl:hasDbXref "EFO:0003485", "EHDAA2:0002092", "EHDAA:377", "EMAPA:16177", "TAO:0000081", "VHOG:0000281", "ZFA:0000081" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trunk and cervical mesenchyme" ; oboInOwl:id "UBERON:0005256" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trunk mesenchyme" ; rdfs:subClassOf _:genid140258 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0005257 obo:IAO_0000115 "Mesenchyme that is part of a developing finger [Automatically generated definition]." ; obo:IAO_0000116 "In EHDAA2, the metacarpal cartilage condensation is considered part of the digits - it might be better to call the whole structure digital ray mesenchyme/condensation" ; oboInOwl:hasDbXref "EHDAA2:0000407", "EMAPA:32645", "VHOG:0001416" ; oboInOwl:hasExactSynonym "finger mesenchyme", "fore limb digit mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior limb digital ray mesenchyme", "finger ray mesenchyme", "manual digital ray mesenchyme" ; oboInOwl:id "UBERON:0005257" ; a owl:Class ; rdfs:label "manual digit mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009523 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0005258 obo:IAO_0000115 "Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0002114", "EMAPA:17426", "VHOG:0000505" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005258" ; a owl:Class ; rdfs:label "upper arm mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0005259 obo:IAO_0000115 "Mesenchyme that is part of a developing lower leg [Automatically generated definition]." ; oboInOwl:hasDbXref "EHDAA2:0001032", "EMAPA:17498", "VHOG:0000752" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005259" ; a owl:Class ; rdfs:label "lower leg mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0005268 obo:IAO_0000115 "An artery that supplies the renal cortex." ; oboInOwl:hasDbXref "EMAPA:28147", "MA:0002582" ; oboInOwl:hasExactSynonym "kidney cortex artery", "renal cortex artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renal cortex arterial system" ; oboInOwl:id "UBERON:0005268" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renal cortex artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001225 ], _:genid140287 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:UBERON_0005269 obo:IAO_0000115 "Artery that receives blood from the renal cortex[MP, modified]." ; oboInOwl:hasDbXref "EMAPA:28152", "MA:0002592" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney cortex vein", "renal cortex venous system" ; oboInOwl:id "UBERON:0005269" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renal cortex vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001225 ], _:genid140298 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:UBERON_0005270 obo:IAO_0000115 "A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells." ; obo:UBPROP_0000010 "In the renal cortex, interstitial fibroblasts produce erythropoietin and are distinguished from other interstitial cells by their prominent F-actin cytoskeleton, abundance of rough endoplasmic reticulum, and by ecto-5'-nucleotidase expression in their plasma membrane. The resident dendritic cells belong to the mononuclear phagocyte system and fulfil a sentinel function. They are characterized by their expression of MHC class II and CD11c." ; oboInOwl:hasDbXref "EMAPA:28136", "MA:0002608", "SCTID:243707006", "Wikipedia:Medullary_interstitium" ; oboInOwl:hasExactSynonym "kidney cortex interstitium", "renal cortical interstitial tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortical stroma" ; oboInOwl:id "UBERON:0005270" ; a owl:Class ; rdfs:label "renal cortex interstitium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000451 ], _:genid140308, _:genid140310 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005169 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:UBERON_0005273 obo:IAO_0000115 "Region of skin beneath the nail plate[WP]." ; oboInOwl:hasDbXref "EMAPA:35581", "EV:0100158", "MA:0002706", "SCTID:181578005", "VHOG:0001362" ; oboInOwl:hasExactSynonym "nailbed" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005273" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail bed" ; rdfs:subClassOf obo:UBERON_0005275, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0008198 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001705 ], _:genid140318 . obo:UBERON_0005275 oboInOwl:hasExactSynonym "dorsal digit skin", "skin of dorsal part of digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005275" ; a owl:Class ; rdfs:label "dorsal skin of digit" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] . obo:UBERON_0005276 obo:IAO_0000115 "A dorsal skin of digit that is part of a manual digit." ; obo:UBPROP_0000012 "this class is explicitly the union of the two FMA classes" ; oboInOwl:hasDbXref "FMA:38320", "FMA:60346" ; oboInOwl:hasExactSynonym "dorsal finger skin", "skin of dorsal part of finger", "subdivision of skin of dorsal part of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005276" ; a owl:Class ; rdfs:label "dorsal skin of finger" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0005277 obo:IAO_0000115 "A dorsal skin of digit that is part of a pedal digit." ; obo:UBPROP_0000012 "this class is explicitly the union of the two FMA classes" ; oboInOwl:hasDbXref "FMA:37868", "FMA:60523" ; oboInOwl:hasExactSynonym "dorsal toe skin", "skin of dorsal part of toe", "subdivision of skin of dorsal part of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005277" ; a owl:Class ; rdfs:label "dorsal skin of toe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005275 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0005278 obo:IAO_0000115 "A nail bed that is part of a manual digit." ; oboInOwl:hasDbXref "FMA:60348", "SCTID:244199003" ; oboInOwl:hasExactSynonym "nail bed of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005278" ; a owl:Class ; rdfs:label "nail bed of finger" ; rdfs:subClassOf obo:UBERON_0005276, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005273 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0005279 obo:IAO_0000115 "A nail bed that is part of a pedal digit." ; oboInOwl:hasDbXref "FMA:60529", "SCTID:244200000" ; oboInOwl:hasExactSynonym "nail bed of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005279" ; a owl:Class ; rdfs:label "nail bed of toe" ; rdfs:subClassOf obo:UBERON_0005277, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005273 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0005281 obo:IAO_0000115 "A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP]." ; obo:IAO_0000116 "TODO - resolve space vs structure conflation. We follow FMA in making this and the various ventricles a structure - it follows from this that strutures such as the tela choroidea and choroid plexuses can be part of the ventricles and ventricular system. Note: see also the class 'neuraxis cavity'" ; oboInOwl:hasDbXref "EFO:0003650", "EHDAA2:0004362", "EV:0100306", "FMA:242675", "MBA:73", "TAO:0001261", "Wikipedia:Ventricular_system", "ZFA:0001261", "neuronames:2497" ; oboInOwl:hasExactSynonym "CNS ventricular system", "ventricular system", "ventricular system of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventricle system", "ventriculi cerebri" ; oboInOwl:id "UBERON:0005281" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "ventricular system of central nervous system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png"^^xsd:anyURI . obo:UBERON_0005282 obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "CALOHA:TS-1295", "EMAPA:37447", "FMA:242787", "VHOG:0000005" ; oboInOwl:hasExactSynonym "brain ventricular system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005282" ; a owl:Class ; rdfs:label "ventricular system of brain" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005281 ] . obo:UBERON_0005283 obo:IAO_0000115 "A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm]." ; obo:UBPROP_0000001 "Portion of tissue that is part of the primitive meninx which forms a fold, roofing a ventricle of the brain and supporting the choroid plexus[ZFA:0000447]." ; obo:UBPROP_0000010 "Vascularized tela choroidea is choroid plexus." ; obo:UBPROP_0000012 "Note that the structure in ZFA may be different" ; oboInOwl:hasDbXref "FMA:242849", "TAO:0000447", "Wikipedia:Tela_chorioidea", "ZFA:0000447", "neuronames:1378" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tela chorioidea" ; oboInOwl:id "UBERON:0005283" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "tela choroidea" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001886 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0010743 ], _:genid140368 . obo:UBERON_0005286 obo:IAO_0000115 "Tela choroidea that lines the tectal ventricle." ; obo:UBPROP_0000001 "Tela chorioidea that lines the tectal ventricle.[TAO]" ; oboInOwl:hasDbXref "TAO:0005157", "ZFA:0005157" ; oboInOwl:hasExactSynonym "tela chorioidea tectal ventricle", "tela choroidea of cerebral aqueduct", "tela choroidea tectal ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005286" ; a owl:Class ; rdfs:label "tela choroidea of midbrain cerebral aqueduct" ; rdfs:subClassOf obo:UBERON_0005283 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002289 ] ) ] . obo:UBERON_0005287 obo:IAO_0000115 "Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP]." ; obo:UBPROP_0000001 "Tela chorioidea that lines the fourth ventricle.[TAO]" ; oboInOwl:hasBroadSynonym "tela choroidea" ; oboInOwl:hasDbXref "BAMS:tc4v", "FMA:78493", "SCTID:362321009", "TAO:0005158", "Wikipedia:Tela_chorioidea_of_fourth_ventricle", "ZFA:0005158", "neuronames:639" ; oboInOwl:hasExactSynonym "choroid membrane", "choroid membrane of fourth ventricle", "tela chorioidea fourth ventricle", "tela choroidea fourth ventricle", "tela choroidea of fourth ventricle", "tela choroidea ventriculi quarti" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tela choroidea ventriculi quarti" ; oboInOwl:id "UBERON:0005287" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "tela choroidea of fourth ventricle" ; rdfs:subClassOf obo:UBERON_0005283, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) ] . obo:UBERON_0005288 obo:IAO_0000115 "Tela chorioidea that lines the third ventricle[ZFA]. The part of the choroid plexus in relation to the body of the ventricle forms the vascular fringed margin of a triangular process of pia mater, named the tela chorioidea of the third ventricle, and projects from under cover of the lateral edge of the fornix. Blood is supplied by branches from the superior cerebellar artery[WP]." ; obo:UBPROP_0000001 "Tela chorioidea that lines the third ventricle.[TAO]" ; oboInOwl:hasDbXref "BAMS:tc3v", "FMA:78463", "SCTID:362320005", "TAO:0005159", "Wikipedia:Tela_chorioidea_of_third_ventricle", "ZFA:0005159", "neuronames:453" ; oboInOwl:hasExactSynonym "choroid membrane of third ventricle", "tela chorioidea of third ventricle", "tela chorioidea third ventricle", "tela choroidea third ventricle", "tela choroidea ventriculi tertii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tela choroidea ventriculi tertii" ; oboInOwl:id "UBERON:0005288" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "tela choroidea of third ventricle" ; rdfs:subClassOf obo:UBERON_0005283, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/60/Gray723.png"^^xsd:anyURI . obo:UBERON_0005289 obo:IAO_0000115 "Tela chorioidea that lines the telencephalic ventricle." ; oboInOwl:hasDbXref "BAMS:tclv", "FMA:83712", "SCTID:362319004", "TAO:0005160", "ZFA:0005160", "neuronames:219" ; oboInOwl:hasExactSynonym "tela chorioidea of lateral ventricle", "tela chorioidea of telencephalic ventricle", "tela chorioidea telencephalic ventricle", "tela choroidea (ventriculi lateralis)", "tela choroidea of lateral ventricle", "tela choroidea telencephalic ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005289" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "tela choroidea of telencephalic ventricle" ; rdfs:subClassOf obo:UBERON_0005283 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005283 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:UBERON_0005290 obo:IAO_0000115 "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." ; obo:UBPROP_0000001 "The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]" ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; obo:UBPROP_0000013 "the terms metencephalon and myelencephalon are only meaningful in mammals and birds - Neuroanatomy of the Zebrafish Brain. Note that its not clear if this refers to the developing medulla oblongata - MA (adult) has two distinct classes" ; oboInOwl:hasDbXref "BTO:0000758", "CALOHA:TS-0607", "CALOHA:TS-2365", "DHBA:10662", "EHDAA2:0001207", "EHDAA:5526", "EMAPA:17082", "HBA:9512", "MA:0000205", "MESH:D054024", "VHOG:0000456", "Wikipedia:Myelencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "myelencephalon (medulla oblongata)" ; oboInOwl:id "UBERON:0005290" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "myelencephalon" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ], _:genid140417 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg"^^xsd:anyURI . obo:UBERON_0005291 obo:IAO_0000115 "A portion of tissue that is part of an embryo." ; oboInOwl:hasDbXref "CALOHA:TS-2100" ; oboInOwl:hasExactSynonym "portion of embryonic tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "developing tissue" ; oboInOwl:id "UBERON:0005291" ; oboInOwl:inSubset core:pheno_slim, core:upper_level ; a owl:Class ; rdfs:label "embryonic tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:UBERON_0005292 obo:IAO_0000115 "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." ; oboInOwl:hasDbXref "BTO:0003360", "CALOHA:TS-2119", "EFO:0001406", "MAT:0000061", "MIAA:0000061" ; oboInOwl:hasExactSynonym "extra-embryonic tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005292" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "extraembryonic tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] ) ] . obo:UBERON_0005294 obo:IAO_0000115 "The elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary." ; obo:IAO_0000116 "TODO - check developmental relationships. merge with urogenital ridge?" ; obo:UBPROP_0000011 "in eutherians, SRY transforms the indifferent gonad into testes" ; oboInOwl:hasDbXref "AAO:0011047", "BTO:0001402", "EFO:0001414", "EHDAA2:0004044", "EMAPA:35899", "FMA:321917", "NCIT:C34184", "NCIT:C34321", "SCTID:308801004", "SCTID:361399001", "UMLS:C0231047", "UMLS:C1512243", "Wikipedia:Gonadal_ridge", "XAO:0000018" ; oboInOwl:hasExactSynonym "genital ridge", "gonadal ridge", "indifferent gonadal ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crista gonadalis", "genital cord" ; oboInOwl:id "UBERON:0005294" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "gonadal ridge" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004122 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004876 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1106.png"^^xsd:anyURI . obo:UBERON_0005295 obo:IAO_0000115 "Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female." ; oboInOwl:hasDbXref "EHDAA2:0004051", "NCIT:C34183", "RETIRED_EHDAA2:0001523", "SCTID:343823004", "UMLS:C1512242", "Wikipedia:Sex_cords" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "genital cord", "gonad cord", "gonadal cord", "primitive sex cord" ; oboInOwl:id "UBERON:0005295" ; a owl:Class ; rdfs:label "sex cord" ; rdfs:subClassOf obo:UBERON_0005154, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005294 ] . obo:UBERON_0005296 obo:IAO_0000115 "Structures that develop from sex cords in the female. After further development they become the ovarian follicles." ; obo:IAO_0000116 "TODO check secondary vs cortical vs ovary" ; oboInOwl:hasDbXref "EHDAA2:0001363", "EHDAA:8130", "EMAPA:31058", "NCIT:C34134", "UMLS:C1511527", "VHOG:0001339", "Wikipedia:Cortical_cords" ; oboInOwl:hasExactSynonym "ovigerous cord", "ovigerous cords" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortical cord", "cortical sex cord", "ovary primitive sex cord", "secondary cord" ; oboInOwl:id "UBERON:0005296" ; a owl:Class ; rdfs:label "ovary sex cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010141 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0005297 obo:IAO_0000115 "The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP]." ; obo:IAO_0000116 "TODO - check primary vs testis" ; oboInOwl:hasDbXref "EHDAA2:0002011", "EHDAA:8152", "EMAPA:29098", "VHOG:0001321", "Wikipedia:Testis_cords" ; oboInOwl:hasExactSynonym "testis cord", "testis primary sex cords" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "primary sex cord", "testis primitive sex cord" ; oboInOwl:id "UBERON:0005297" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "testis sex cord" ; rdfs:subClassOf _:genid140463 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] . obo:UBERON_0005298 obo:IAO_0000115 "A zone of skin that is part of a clitoris [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:20168", "SCTID:361374002" ; oboInOwl:hasExactSynonym "clitoris skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005298" ; a owl:Class ; rdfs:label "skin of clitoris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] . obo:UBERON_0005299 obo:IAO_0000115 "A retractable double-layered fold of skin and mucous membrane that covers the clitoral glans." ; obo:UBPROP_0000008 "FMA has FMA:27886 skin of prepuce of clitoris" ; oboInOwl:hasDbXref "EMAPA:30699", "FMA:20169", "NCIT:C32590", "SCTID:362242009", "UMLS:C0227771", "Wikipedia:Clitoral_hood" ; oboInOwl:hasExactSynonym "clitoral hood", "clitoral prepuce", "clitoris prepuce", "prepuce of female", "prepuce of the clitoris", "preputium clitoridis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005299" ; a owl:Class ; rdfs:label "prepuce of clitoris" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006653 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0035006 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011374 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Clitoris_outer_anatomy.gif"^^xsd:anyURI . obo:UBERON_0005309 obo:IAO_0000115 "A pronephric nephron is the functional unit of the pronephros[GO]." ; obo:UBPROP_0000001 "The structure that is the basic functional unit of the pronephros.[AAO]" ; oboInOwl:hasDbXref "AAO:0011091", "XAO:0000285" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005309" ; a owl:Class ; rdfs:label "pronephric nephron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:UBERON_0005310 obo:IAO_0000115 "The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO]." ; obo:UBPROP_0000001 "Bilaterally paired tubes connecting the pronephric glomeruli to the pronephric ducts. In zebrafish and other teleosts, the pronephric nephron and tubules form after the pronephric duct, connecting to the anterior-most tip of the pronephric ducts. Drummond, 2000.[TAO]" ; oboInOwl:hasDbXref "TAO:0001558", "XAO:0004105", "ZFA:0001558" ; oboInOwl:hasExactSynonym "pronephric tubule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ciliated neck segment" ; oboInOwl:id "UBERON:0005310" ; a owl:Class ; rdfs:label "pronephric nephron tubule" ; rdfs:subClassOf _:genid140494 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001231 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005309 ] ) ] . obo:UBERON_0005311 obo:IAO_0000115 "The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO]." ; obo:IAO_0000116 "TODO develops_from" ; obo:UBPROP_0000008 "in mouse, five pairs of symmetrically positioned mammary placodes (three thoracic and two inguinal) form at reproducible locations along the mammary line at E11.5; the individual pairs develop asynchronously and in a distinct order; pair 3 is first, followed by pair 4, then by pairs 1 and 5 (which develop together), and finally by pair 2; the orientation of placodal cells is not uniform, suggesting that placodes are formed by migration of cells from the mammary line; between E11.5 and E12.5, each mammary placode expands and invaginates into the underlying mesenchyme to form an early bulb-shaped mammary bud[MP]" ; oboInOwl:hasDbXref "EMAPA:35541" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary anlage" ; oboInOwl:id "UBERON:0005311" ; a owl:Class ; rdfs:label "mammary placode" ; rdfs:subClassOf obo:UBERON_0011814, _:genid140501, _:genid140503 . obo:UBERON_0005316 obo:IAO_0000115 "The endothelial lining of the endocardium." ; oboInOwl:hasDbXref "FMA:83596" ; oboInOwl:hasExactSynonym "endocardium endothelium", "endothelium of endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005316" ; a owl:Class ; rdfs:label "endocardial endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002165 ] ) ] . obo:UBERON_0005317 obo:IAO_0000115 "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." ; oboInOwl:hasDbXref "BTO:0000137" ; oboInOwl:hasExactSynonym "pulmonary artery endothelial tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005317" ; a owl:Class ; rdfs:label "pulmonary artery endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:UBERON_0005319 obo:IAO_0000115 "The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO]." ; oboInOwl:hasDbXref "AAO:0010390", "XAO:0000151" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005319" ; a owl:Class ; rdfs:label "mesonephric collecting duct" ; rdfs:subClassOf _:genid140523 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001232 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005321 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005321" ; a owl:Class ; rdfs:label "mesonephric smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005322 obo:IAO_0000115 "A nephron that is part of a mesonephros." ; obo:UBPROP_0000001 "The structure that is the basic functional unit of the kidney.[AAO]" ; oboInOwl:hasDbXref "AAO:0010387", "XAO:0000292", "ZFA:0005592" ; oboInOwl:hasExactSynonym "nephron of mesonephros" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "stage IV nephron" ; oboInOwl:id "UBERON:0005322" ; a owl:Class ; rdfs:label "mesonephric nephron" ; rdfs:subClassOf _:genid140535 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001285 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005323 obo:IAO_0000115 "Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO]." ; oboInOwl:hasDbXref "AAO:0011062", "EHDAA2:0001132", "EMAPA:16745", "XAO:0000291" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005323" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mesonephric mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005325 obo:IAO_0000115 "The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO]." ; obo:UBPROP_0000001 "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated.[AAO]" ; obo:UBPROP_0000003 "In animals in which the mesonephros is the terminal kidney, such as amphibians and fish, the final organ is very complex, containing a large number of nephrons, most of which have an internal glomerulus.[well established][VHOG]" ; obo:UBPROP_0000012 "XAO/AAO class belongs here, as it refers to mesonephric structure" ; oboInOwl:hasBroadSynonym "glomerulus" ; oboInOwl:hasDbXref "AAO:0010388", "EMAPA:30568", "SCTID:362217000", "VHOG:0001238", "XAO:0000146" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005325" ; a owl:Class ; rdfs:label "mesonephric glomerulus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000074 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005326 obo:IAO_0000115 "The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005326" ; a owl:Class ; rdfs:label "mesonephric glomerulus vasculature" ; rdfs:subClassOf _:genid140558 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004190 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005327 obo:IAO_0000115 "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005327" ; a owl:Class ; rdfs:label "mesonephric glomerular epithelium" ; rdfs:subClassOf _:genid140565, _:genid140567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004188 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005328 obo:IAO_0000115 "The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005328" ; a owl:Class ; rdfs:label "mesonephric comma-shaped body" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004198 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005330 obo:IAO_0000115 "The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005330" ; a owl:Class ; rdfs:label "mesonephric nephron epithelium" ; rdfs:subClassOf _:genid140579 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005331 obo:IAO_0000115 "The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." ; oboInOwl:hasDbXref "SCTID:361407006", "ZFA:0005586" ; oboInOwl:hasExactSynonym "mesonephric vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005331" ; a owl:Class ; rdfs:label "mesonephric renal vesicle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005330 ], _:genid140586 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004209 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005332 obo:IAO_0000115 "The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005332" ; a owl:Class ; rdfs:label "mesonephric S-shaped body" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004199 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0005333 obo:IAO_0000115 "A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland." ; obo:UBPROP_0000011 "produced along the length of the embryonic mammary ridge these buds represent the future locations of the mammary glands. Invagination of ectoderm at each bud leads to the development of epithelial diverticula, later maturing as lactiferous ducts" ; oboInOwl:hasAlternativeId "UBERON:0004181" ; oboInOwl:hasDbXref "EMAPA:35536" ; oboInOwl:hasExactSynonym "lactiferous gland bud", "mammary gland bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary primordium", "milk bud" ; oboInOwl:id "UBERON:0005333" ; a owl:Class ; rdfs:label "mammary bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005153 [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0005311 ] ) ] . obo:UBERON_0005334 obo:IAO_0000115 "A lamina propria that is part of a mucosa of oral region." ; oboInOwl:hasDbXref "EMAPA:26947" ; oboInOwl:hasExactSynonym "lamina propria of oral mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005334" ; a owl:Class ; rdfs:label "oral lamina propria" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003343 ] ) ] . obo:UBERON_0005337 obo:IAO_0000115 "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." ; oboInOwl:hasDbXref "FMA:13225", "Wikipedia:Ventricular_outflow_tract", "XAO:0004140" ; oboInOwl:hasExactSynonym "heart ventricle outflow tract", "outflow part of ventricle", "ventricular outflow tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005337" ; a owl:Class ; rdfs:label "outflow tract of ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004145 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0005338 obo:IAO_0000115 "An outflow tract that is part of a aorta." ; obo:IAO_0000116 "merge with LVOT?" ; oboInOwl:hasDbXref "EHDAA2:0001353", "EMAPA:17329", "MA:0000101", "VHOG:0001394" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005338" ; a owl:Class ; rdfs:label "outflow tract aortic component" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004145 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] ) ] . obo:UBERON_0005339 obo:IAO_0000116 "merge with RVOT?" ; oboInOwl:hasDbXref "EHDAA2:0001359", "EHDAA:4401", "EMAPA:17330", "MA:0000102", "VHOG:0001395" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005339" ; a owl:Class ; rdfs:label "outflow tract pulmonary component" ; rdfs:subClassOf obo:UBERON_0004145 . obo:UBERON_0005340 obo:IAO_0000115 "A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP]." ; oboInOwl:hasDbXref "EMAPA:37844", "NLX:147892" ; oboInOwl:hasExactSynonym "dorsal commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005340" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dorsal telencephalic commissure" ; rdfs:subClassOf obo:UBERON_0001020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000203 ] ; owl:disjointWith obo:UBERON_0005341 . obo:UBERON_0005341 obo:IAO_0000115 "The fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures[MP]." ; oboInOwl:hasDbXref "EMAPA:37845" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005341" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ventral commissure" ; rdfs:subClassOf obo:UBERON_0005970, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000204 ] . obo:UBERON_0005343 obo:IAO_0000115 "The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP]." ; obo:UBPROP_0000011 "A single stem cell in the ventricular layer can give rise to neurons (and glial cells) in any of the cortical layers (Walsh and Cepko 1988)[NCBIBook:NBK10047]", "in humans develops into cortical layers II-VI" ; oboInOwl:hasBroadSynonym "CP", "CxP" ; oboInOwl:hasDbXref "BAMS:CTXpl", "DHBA:10515", "EMAPA:32711", "MBA:695", "PBA:294021914", "neuronames:2702" ; oboInOwl:hasExactSynonym "cerebral cortex cortical plate", "future cortical layers II-VI", "neocortex cortical plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future neocortex" ; oboInOwl:id "UBERON:0005343" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cortical plate" ; rdfs:subClassOf obo:UBERON_0014950, _:genid140627 . obo:UBERON_0005352 obo:IAO_0000115 "The cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis[MP]." ; oboInOwl:hasDbXref "FMA:19937", "GAID:395", "MESH:D013085", "NCIT:C12329", "SCTID:181433005", "UMLS:C0037855", "Wikipedia:Spermatic_cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "funiculus spermaticus", "spermatic chord" ; oboInOwl:id "UBERON:0005352" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spermatic cord" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004054 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001000 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004054 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png"^^xsd:anyURI . obo:UBERON_0005358 obo:IAO_0000115 "A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord." ; oboInOwl:hasDbXref "EMAPA:35209", "FMA:242770" ; oboInOwl:hasExactSynonym "ventricular layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "region of wall of ventricular system of neuraxis" ; oboInOwl:id "UBERON:0005358" ; a owl:Class ; rdfs:label "ventricle of nervous system" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0005362 obo:IAO_0000115 "The group of sensory neuron cell bodies associated with the vagus nerve." ; oboInOwl:hasBroadSynonym "gX" ; oboInOwl:hasDbXref "EMAPA:16798", "FMA:53472", "MA:0001081", "SCTID:244452001", "TAO:0007067", "VHOG:0000684", "Wikipedia:Vagus_ganglion", "ZFA:0007067" ; oboInOwl:hasExactSynonym "ganglion of vagus nerve", "right glossopharyngeal ganglion", "vagal ganglion", "vagus ganglion", "vagus neural ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vagus X" ; oboInOwl:id "UBERON:0005362" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vagus X ganglion" ; rdfs:subClassOf obo:UBERON_0009127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001759 ] ) ] . obo:UBERON_0005363 obo:IAO_0000115 "The large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)." ; obo:UBPROP_0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "inferior vagus X" ; oboInOwl:hasDbXref "EFO:0002516", "EHDAA2:0004622", "EMAPA:17155", "FMA:6230", "MA:0001082", "MESH:D009620", "SCTID:14420006", "VHOG:0000685", "Wikipedia:Inferior_ganglion_of_vagus_nerve" ; oboInOwl:hasExactSynonym "ganglion inferius (nervus vagus)", "ganglion inferius nervi vagi", "ganglion inferius nervus vagi", "ganglion nodosum", "inferior ganglion of vagus", "inferior ganglion of vagus nerve", "nodose ganglion", "tenth cranial nerve nodose ganglion", "vagus nerve inferior ganglion", "vagus nerve nodose ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inferior vagus ganglion", "nodose ganglia", "vagus X inferior ganglion" ; oboInOwl:id "UBERON:0005363" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "inferior vagus X ganglion" ; rdfs:subClassOf obo:UBERON_0005362, _:genid140656, _:genid140658 . obo:UBERON_0005366 obo:IAO_0000115 "The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions." ; obo:UBPROP_0000001 "Part of the telencephalon, comprised of paired anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits. In Xenopus,the olfactory bulbs begin to fuse at NF stage 50, fusion is complete around NF stage 58. The cerebral vein loops around the olfactory bulb by NF stage 43[XAO:0004180]." ; obo:UBPROP_0000003 "(In mammals) Odorant detection is mediated by millions of olfactory sensory neurons located in the olfactory epithelium lining the nasal cavity. These neurons transmit sensory signals to the olfactory bulb of the brain, which in turn sends signals to the olfactory cortex.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0001362", "EFO:0000108", "EHDAA2_RETIRED:0001294", "EHDAA:5480", "EMAPA:17778", "MA:0002413", "MIAA:0000116", "NCIT:C33204", "UMLS:C0178780", "VHOG:0000833", "neuronames:2078" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005366" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "olfactory lobe" ; rdfs:subClassOf obo:UBERON_0016526, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] . obo:UBERON_0005367 obo:IAO_0000116 "TODO - check this. The granule layer is typically in the dentate gyrus, under some definitions of hippocampus, the DG is included, thus making this layer a hippocampal layer" ; oboInOwl:hasDbXref "EMAPA:35406", "MA:0000954" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hippocampus granular layer" ; oboInOwl:id "UBERON:0005367" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hippocampus granule cell layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002305 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0001033 ] ) ] . obo:UBERON_0005373 obo:IAO_0000115 "The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception." ; obo:IAO_0000116 "TODO - relationship with dorsal horn?" ; obo:UBPROP_0000001 "The dorsolateral ridge of gray matter in each lateral half of the spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000009 "The dorsal column is a part of the spinal cord which is responsible for transporting sensory input from the body to the cerebral cortex. This part of the spinal cord is key in perceiving fine touch, such as that used to distinguish textures, along with vibration. The dorsal column also contributes to the body's system of proprioception, used to orient the body in space and to coordinate muscle movements, given information about the body's position" ; oboInOwl:hasDbXref "BAMS:dc", "EV:0100317", "MA:0002749", "MBA:514", "NCIT:C33355", "UMLS:C0458459", "VHOG:0001623", "Wikipedia:Posterior_column", "neuronames:2681" ; oboInOwl:hasExactSynonym "dorsal column", "dorsal column of spinal cord", "posterior column", "spinal cord posterior column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal column system", "dorsal columns" ; oboInOwl:id "UBERON:0005373" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spinal cord dorsal column" ; rdfs:subClassOf obo:UBERON_0016550, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002258 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002318 ], _:genid140686 ; owl:disjointWith obo:UBERON_0005375 . obo:UBERON_0005375 obo:IAO_0000115 "The area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure." ; obo:UBPROP_0000001 "The ventral ridge of gray matter in each half of the spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000012 "in MA, this is a subclass of white matter, but in WP/Gray's, the anterior column is a synonym of the grey matter section. is this the same as funiculus? See lateral column." ; oboInOwl:hasDbXref "EV:0100326", "MA:0002751", "VHOG:0001622", "neuronames:269" ; oboInOwl:hasExactSynonym "anterior column", "spinal cord anterior column", "ventral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005375" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spinal cord ventral column" ; rdfs:subClassOf obo:UBERON_0016550, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002180 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002318 ] . obo:UBERON_0005382 obo:IAO_0000115 "Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't." ; obo:UBPROP_0000001 "According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum", "According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (putamen and the globus pallidus) and the caudate nucleus", "It may also refer to both the basal ganglia and the internal capsule collectively.", "It may also refer to the putamen and caudate collectively.", "The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance." ; oboInOwl:hasDbXref "BAMS:Dorsal_striatum", "BAMS:STRd", "BAMS:StrD", "BTO:0004701", "EMAPA:36575", "FMA:77620", "MA:0002971", "MBA:485", "NLXANAT:1010001", "PBA:10081", "Wikipedia:Dorsal_striatum", "neuronames:2340" ; oboInOwl:hasExactSynonym "striatum dorsal region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudoputamen", "corpus striatum", "dorsal basal ganglia", "dorsal basal ganglion", "striated body", "striatum dorsale" ; oboInOwl:id "UBERON:0005382" ; a owl:Class ; rdfs:label "dorsal striatum" ; rdfs:subClassOf obo:UBERON_0002020, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001873 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001874 ], _:genid140701 . obo:UBERON_0005383 obo:IAO_0000115 "Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure." ; obo:IAO_0000116 "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)", "we do not currently place rodent-specific taxon constraints here as this would cause taxon violations. There is an argument for merging this into dorsal striatum and treating the distinction as phenotypic" ; obo:UBPROP_0000011 "In the human, histologically the caudate nucleus and putamen are identically and share a common embryological origin[ISBN:0123813611]" ; oboInOwl:hasDbXref "BAMS:CP", "BAMS:CPu", "BM:Tel-C-Pu", "BTO:0000212", "EFO:0001912", "EMAPA:19095", "MA:0000893", "MBA:672", "NLXANAT:100312" ; oboInOwl:hasExactSynonym "caudate putamen", "caudateputamen", "caudoputamen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudate putamen", "caudate putamen (striatum)", "caudate-putamen", "caudateputamen", "dorsal striatum", "neostriatum", "striatum" ; oboInOwl:id "UBERON:0005383" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "caudate-putamen" ; rdfs:subClassOf obo:UBERON_0011215, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001873 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002435 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002020 ], _:genid140718 . obo:UBERON_0005384 obo:IAO_0000115 "An epithelium that lines the nasal cavity." ; obo:IAO_0000116 "this class may in future be split into the embryonic precursor of the oronasal membrane and the structure that is part of the mucosa in the developed organism" ; oboInOwl:hasDbXref "CALOHA:TS-0656", "EHDAA2:0001227", "EHDAA:6803", "EMAPA:17605", "FMA:63140", "MA:0001324", "NCIT:C49261", "UMLS:C1709151", "VHOG:0000501" ; oboInOwl:hasExactSynonym "nasal epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal mucosa" ; oboInOwl:id "UBERON:0005384" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasal cavity epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0015788 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004785 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] . obo:UBERON_0005388 obo:IAO_0000115 "An array of photoreceptors and any supporting cells found in an eye." ; oboInOwl:hasDbXref "FBbt:00004200" ; oboInOwl:hasExactSynonym "light-sensitive tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005388" ; a owl:Class ; rdfs:label "photoreceptor array" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000210 ] ) ] . obo:UBERON_0005389 obo:IAO_0000115 "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." ; obo:UBPROP_0000009 "directing or focusing light onto light receptors" ; oboInOwl:hasNarrowSynonym "lens" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005389" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "transparent eye structure" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000964 ] . obo:UBERON_0005396 obo:IAO_0000115 "One of: the common carotid artery, or its branches, the external and internal carotid arteries." ; obo:IAO_0000116 "This is a generic grouping class that is the superclass of the trunks/branches of the common carotid artery. Note that AOs vary widely in how they divide up and generalize arteries" ; obo:UBPROP_0000001 "Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO]" ; oboInOwl:hasDbXref "AAO:0010217", "BTO:0000168", "CALOHA:TS-0116", "EFO:0000818", "EHDAA:6385", "EMAPA:18609", "EV:0100379", "FMA:70504", "GAID:478", "MA:0001925", "MAT:0000501", "MESH:D002339", "NCIT:C12687", "SCTID:362040006", "SCTID:69105007", "TAO:0000097", "UMLS:C0007272", "VHOG:0000266", "Wikipedia:Carotid_artery", "ZFA:0000097", "galen:CarotidArtery" ; oboInOwl:hasExactSynonym "carotid", "carotid artery", "subdivision of common carotid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "common carotid arterial subdivision" ; oboInOwl:id "UBERON:0005396" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "carotid artery segment" ; rdfs:subClassOf obo:UBERON_0004573 . obo:UBERON_0005397 obo:IAO_0000115 "An arachnoid mater that surrounds a brain." ; obo:UBPROP_0000001 "The middle membrane of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" ; obo:UBPROP_0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:32661", "FMA:83981", "MA:0000814", "NCIT:C49331", "UMLS:C1707346", "VHOG:0000230" ; oboInOwl:hasExactSynonym "arachnoidea mater cranialis", "arachnoidea mater encephali", "brain arachnoid matter", "cranial arachnoid mater" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005397" ; a owl:Class ; rdfs:label "brain arachnoid mater" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003547 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0005398 obo:IAO_0000115 "A sex gland that is part of a female reproductive system." ; oboInOwl:hasDbXref "BTO:0000254", "MA:0000383" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005398" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "female reproductive gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003937 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0005399 obo:IAO_0000115 "A sex gland that is part of a male reproductive system." ; oboInOwl:hasDbXref "BTO:0000080", "EMAPA:19285", "MA:0000399" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "accessory sex gland" ; oboInOwl:id "UBERON:0005399" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "male reproductive gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003937 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0005400 obo:IAO_0000115 "An arachnoid mater that is part of a telencephalon." ; oboInOwl:hasDbXref "EMAPA:17775", "MA:0000980" ; oboInOwl:hasExactSynonym "telencephalon arachnoid matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005400" ; a owl:Class ; rdfs:label "telencephalon arachnoid mater" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002362 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0005401 obo:IAO_0000115 "A gray matter that is part of a cerebral hemisphere." ; obo:UBPROP_0000012 "BTO may actually be a more generic structure; FMA may represent a more specific structure. Consider merging with gray matter of telencephalon" ; oboInOwl:hasDbXref "BTO:0000823", "CALOHA:TS-2361", "EMAPA:37477", "FMA:61821", "MA:0000944" ; oboInOwl:hasExactSynonym "cerebral gray matter", "cerebral grey matter", "cerebral hemisphere grey matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005401" ; a owl:Class ; rdfs:label "cerebral hemisphere gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] ) ] . obo:UBERON_0005402 obo:IAO_0000115 "The vertical groove found on the median line of the upper lip, extending to the nose." ; obo:UBPROP_0000008 "vestigial in humans. In humans, the philtrum is formed where the nasomedial and maxillary processes meet during embryonic development (colloquially known as Hulse lines). When these processes fail to fuse fully in humans, a cleft lip (sometimes called a 'hare lip') can result. A flattened or smooth philtrum can be a symptom of fetal alcohol syndrome or Prader-Willi syndrome" ; oboInOwl:hasDbXref "EHDAA2:0001462", "EHDAA:9280", "EMAPA:17926", "FMA:59819", "MA:0001577", "SCTID:362087004", "VHOG:0000862", "Wikipedia:Philtrum" ; oboInOwl:hasExactSynonym "lip philtrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "infranasal depression", "medial cleft", "philtral region of upper lip" ; oboInOwl:id "UBERON:0005402" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Philtrum is modelled as the groove rather than the surface structure itself." ; rdfs:label "philtrum" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/pull/2691" ; rdfs:subClassOf obo:UBERON_0006846, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011256 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001834 ], _:genid140804, _:genid140807 . obo:UBERON_0005403 obo:IAO_0000115 "A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info)." ; obo:UBPROP_0000001 "The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 )." ; oboInOwl:hasDbXref "BAMS:STRv", "BAMS:StrV", "BAMS:Ventral_striatum", "BTO:0004702", "DMBA:15858", "EFO:0001936", "EMAPA:36576", "FMA:77614", "MA:0002972", "MBA:493", "MESH:D066328", "NLX:57107", "PBA:10091", "Wikipedia:Ventral_striatum", "neuronames:2341" ; oboInOwl:hasExactSynonym "striatum ventral region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "striatum ventrale" ; oboInOwl:id "UBERON:0005403" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "ventral striatum" ; rdfs:subClassOf obo:UBERON_0002020, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002435 ], _:genid140815 . obo:UBERON_0005404 obo:IAO_0000115 "A suture between frontal and nasal bones." ; oboInOwl:hasDbXref "EMAPA:35359", "FMA:52948", "MA:0002973", "SCTID:368982004" ; oboInOwl:hasExactSynonym "frontonasal suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulation of the nasal bone with frontal bone" ; oboInOwl:id "UBERON:0005404" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "frontonasal suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009198 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001681 ] ) ] . obo:UBERON_0005407 obo:IAO_0000115 "The small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland." ; oboInOwl:hasDbXref "EHDAA2:0001938", "EHDAA:10101", "FMA:77591", "MA:0002982" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005407" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sublingual ganglion" ; rdfs:subClassOf _:genid140834 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001832 ] ) ] . obo:UBERON_0005408 obo:IAO_0000115 "Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow." ; obo:UBPROP_0000008 "All vertebrates possess at least 4 circumventricular organs (including the hypothalamus) which can monitor the contents of the cerebrospinal fluid and secrete additional substances into it. (Butler, 1996, p. 330)" ; obo:UBPROP_0000010 "CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances" ; oboInOwl:hasDbXref "EMAPA:35243", "FMA:84081", "MA:0002942", "MESH:D066280", "NLXANAT:20090312", "Wikipedia:Circumventricular_organs", "neuronames:1242" ; oboInOwl:hasExactSynonym "CVO", "circumventricular organ", "circumventricular organ of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005408" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "circumventricular organ" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png"^^xsd:anyURI . obo:UBERON_0005409 obo:IAO_0000115 "The part of the digestive system that excludes the hepatobiliary system." ; obo:IAO_0000116 "the decision to split digestive and gastrointestinal in this way may be revisited. As it currently stands, this class more closely aligns what MA calls the alimentary system" ; obo:UBPROP_0000001 "The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System]." ; obo:UBPROP_0000003 "All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG]" ; obo:UBPROP_0000012 "that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla." ; oboInOwl:hasDbXref "BTO:0000058", "CALOHA:TS-0407", "EHDAA2:0000110", "EHDAA:514", "EMAPA:16246", "EV:0100056", "FMA:71132", "GAID:294", "MA:0000323", "MESH:D041981", "NCIT:C12378", "SCTID:373871007", "UMLS:C0012240", "VHOG:0000412", "galen:GastrointestinalTract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "GI tract", "alimentary system", "alimentary tract", "gastro-intestinal system", "gastroenterological system", "gastrointestinal (GI) tract", "gastrointestinal system", "gastrointestinal tract" ; oboInOwl:id "UBERON:0005409" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "alimentary part of gastrointestinal system" ; rdfs:subClassOf obo:UBERON_0000467, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] . obo:UBERON_0005410 obo:IAO_0000115 "An otic capsule endochondral element that is composed primarily of cartilage tissue." ; obo:UBPROP_0000001 "Bilaterally paired cartilage encasing the semicircular canals of the inner ear.[TAO]" ; obo:UBPROP_0000002 "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: develops_from neurocranium (UBERON:0001703)[TAO]", "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: part_of neurocranium (UBERON:0001703)[TAO]" ; obo:UBPROP_0000008 "In elasmobranchs, the otic capsule remains cartilaginous in the adult; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony (at approximately 23 weeks in humans). todo - check EMAPA" ; oboInOwl:hasAlternativeId "UBERON:0010351" ; oboInOwl:hasDbXref "EHDAA2:0001333", "EHDAA:4704", "EMAPA:17596", "EMAPA:18803", "EMAPA:37467", "TAO:0001500", "ZFA:0001500" ; oboInOwl:hasExactSynonym "auditory capsule", "otic capsule cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005410" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "cartilaginous otic capsule" ; rdfs:subClassOf _:genid140861 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004637 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0005411 obo:IAO_0000115 "The cartilage or bony capsule surrounding the inner ear mechanism." ; obo:UBPROP_0000008 "In elasmobranchs, the otic capsule remains cartilaginous in the adult; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony (at approximately 23 weeks in humans)" ; oboInOwl:hasDbXref "EMAPA:17596", "EMAPA:37466", "MA:0000252" ; oboInOwl:hasExactSynonym "otic capsule bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005411" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bony otic capsule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005410 ], _:genid140873 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004637 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0005412 obo:IAO_0000115 "Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary]." ; obo:UBPROP_0000001 "A break in the continuity of the optic cup where the two sides of the cup meet.[AAO]" ; obo:UBPROP_0000003 "The folded arrangement of the vertebrate retina and RPE [retinal pigment epithelial] provides an evolutionary explanation for the occurrence of the choroid fissure, as proposed more than a century ago. Early in evolution, before the optic cup invaginated, the axons from retinal ganglion cells would simply have run over the surface of the structure. Hence, one can view the optic nerve as having acted rather like a rope in linking the retina to higher centres: the developing eye cup has simply wrapped around this 'rope', and the developing axons have thereby not needed to penetrate the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011026", "EHDAA2:0001319", "EHDAA:4759", "EMAPA:17166", "MA:0001305", "RETIRED_EHDAA2:0000249", "SCTID:361508004", "TAO:0001284", "VHOG:0000655", "Wikipedia:Choroid_fissure", "XAO:0000474", "ZFA:0001284" ; oboInOwl:hasExactSynonym "choroid fissure - optic fissure", "optic fissures", "optic stalk fissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "choroid fissure", "ventral choroidal fissure" ; oboInOwl:id "UBERON:0005412" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Develeopment notes: As the eye starts to develop, a gap opens on the underside of each eye bud. This gap provides a way for the developing eye to be nourished. This gap, called the optic fissure, has to close before the eye is fully developed. Coloboma is the incomplete closer of the optic fissure" ; rdfs:label "optic fissure" ; rdfs:subClassOf obo:UBERON_0006846, _:genid140879, _:genid140881 ; owl:disjointWith obo:UBERON_0005745 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/98/Gray865.png"^^xsd:anyURI . obo:UBERON_0005413 obo:IAO_0000115 "This tract conveys interoceptive, proprioceptive, and exteroceptive information from the body's internal organs, and from the trunk, extremities, and neck region to the Cerebellum." ; obo:UBPROP_0000001 "The spinocerebellar tract is a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. This tract conveys information to the cerebellum about limb and joint position[Wikipedia:Spinocerebellar_tract]." ; oboInOwl:hasDbXref "BAMS:sc", "DHBA:12749", "GAID:733", "MBA:85", "MESH:D020824", "NLX:60355", "NLXANAT:1005036", "Wikipedia:Spinocerebellar_tract", "neuronames:1978" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005413" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spinocerebellar tract" ; rdfs:subClassOf obo:UBERON_0001018, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Spinal_cord_tracts_-_English.svg"^^xsd:anyURI . obo:UBERON_0005417 obo:IAO_0000115 "A limb bud that develops into a forelimb." ; oboInOwl:hasDbXref "AAO:0010381", "BTO:0001645", "EHDAA:1699", "EMAPA:16406", "FMA:296782", "MIAA:0000065", "RETIRED_EHDAA2:0003198", "SCTID:346062002", "XAO:0003065" ; oboInOwl:hasExactSynonym "anterior limb bud", "limb bud - forelimb", "upper limb bud" ; oboInOwl:hasNarrowSynonym "wing bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm bud" ; oboInOwl:id "UBERON:0005417" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Genes: Tbx5 specifies forelimbs. Wnt2b restricts Fgf10 in chick // In tetrapods, the position of the forelimb is associated with the anterior expression border of Hoxc6 in the paraxial mesoderm (Burke et al., 1995)" ; rdfs:label "forelimb bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ] ; owl:disjointWith obo:UBERON_0005418 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004347 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0005418 obo:IAO_0000115 "A limb bud that develops into a hindlimb." ; obo:UBPROP_0000001 "The bilateral thickening of the ectoderm in the region of the first noticeable at NF stage 47, and innervated by NF stage 51. The hind limb buds develop before the forelimb buds.[AAO]" ; oboInOwl:hasDbXref "AAO:0010382", "EHDAA:2358", "EMAPA:16779", "MIAA:0000256", "RETIRED_EHDAA2:0003197", "SCTID:346164003", "XAO:0003066" ; oboInOwl:hasExactSynonym "hind limb bud", "posterior limb bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "leg bud", "limb bud - hindlimb" ; oboInOwl:id "UBERON:0005418" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Genes: Tbx4 specifies hindlimbs. Wnt8c restricts Fgf10 in chick." ; rdfs:label "hindlimb bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004347 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0005419 obo:IAO_0000115 "A limb bud that develops into a forelimb or pectoral fin." ; obo:UBPROP_0000001 "Fin bud that develops into the pectoral fin.[TAO]" ; obo:UBPROP_0000003 "While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EFO:0003430", "TAO:0000141", "VHOG:0001754", "VHOG_RETIRED:0001259", "ZFA:0000141" ; oboInOwl:hasExactSynonym "forelimb - pectoral fin bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pectoral fin bud", "pectoral fin buds" ; oboInOwl:id "UBERON:0005419" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future" ; rdfs:label "pectoral appendage bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004357 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0005420 obo:IAO_0000115 "A limb bud that develops into a hindlimb or pelvic fin." ; obo:RO_0002161 obo:NCBITaxon_31033 ; obo:UBPROP_0000001 "Fin bud that develops into the pelvic fin.[TAO]" ; obo:UBPROP_0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003469", "TAO:0001384", "VHOG:0001260", "ZFA:0001384" ; oboInOwl:hasExactSynonym "hindlimb/pelvic fin bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic fin bud", "pelvic fin buds" ; oboInOwl:id "UBERON:0005420" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "at this time we have no need to name a more specific 'pelvic fin bud' class, but we may in future" ; rdfs:label "pelvic appendage bud" ; rdfs:subClassOf _:genid139575 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004357 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0005421 obo:IAO_0000115 "An apical ectodermal ridge that is part of a pectoral appendage bud." ; obo:UBPROP_0000001 "An ectodermal thickening at the end of the forelimb bud in the developing embryo. [TFD][VHOG]", "Apical ectodermal ridge that is part of the pectoral fin bud.[TAO]" ; obo:UBPROP_0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003487", "EHDAA2:0000138", "EMAPA:16778", "TAO:0000085", "TAO:0000736", "VHOG:0001064", "ZFA:0000085" ; oboInOwl:hasNarrowSynonym "AER forelimb", "apical ectodermal ridge forelimb", "apical ectodermal ridge pectoral fin bud", "upper limb bud apical ectodermal ridge", "wing AER", "wing apical ectodermal ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aer pectoral fin", "apical ectodermal ridge pectoral fin", "apical fold pectoral fin" ; oboInOwl:id "UBERON:0005421" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pectoral appendage apical ectodermal ridge" ; rdfs:subClassOf _:genid140943 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004356 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005419 ] ) ] . obo:UBERON_0005422 obo:IAO_0000115 "An apical ectodermal ridge that is part of a pelvic appendage bud." ; obo:UBPROP_0000001 "An ectodermal thickening at the end of the hindlimb bud in the developing embryo. [TFD][VHOG]", "Apical ectodermal ridge that is part of the pelvic fin bud.[TAO]" ; obo:UBPROP_0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003681", "EHDAA2:0003194", "EMAPA:16892", "TAO:0001385", "VHOG:0001066", "ZFA:0001385" ; oboInOwl:hasNarrowSynonym "apical ectodermal ridge hind limb", "apical ectodermal ridge hindlimb", "lower lmb bud apical ectodermal ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "AER hindlimb", "apical ectodermal ridge pelvic fin bud", "leg AER" ; oboInOwl:id "UBERON:0005422" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pelvic appendage apical ectodermal ridge" ; rdfs:subClassOf _:genid140962 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004356 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005420 ] ) ] . obo:UBERON_0005423 obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AEO:0000125", "CALOHA:TS-2122", "EHDAA2:0003125", "FBbt:00007006", "FMA:292313", "MIAA:0000019" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "developing structure", "developmental structure", "developmental tissue" ; oboInOwl:id "UBERON:0005423" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "developing anatomical structure" ; rdfs:subClassOf obo:UBERON_0000465, [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0032502 ] . obo:UBERON_0005424 obo:IAO_0000115 "Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001306", "EMAPA:16677", "TAO:0000064", "VHOG:0000492", "ZFA:0000064" ; oboInOwl:hasExactSynonym "future RPE", "future retinal pigmented epithelium", "optic cup outer layer", "outer layer optic cup", "presumptive pigmented epithelia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future PRE", "future pigmented layer", "future pigmented retinal epithelium", "presumptive pigmented epithelium" ; oboInOwl:id "UBERON:0005424" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "presumptive retinal pigmented epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001782 ] ) ] . obo:UBERON_0005425 obo:IAO_0000115 "Portion of tissue that is the inner layer of the optic cup and will become the neural retina." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001304", "EMAPA:16675", "TAO:0001071", "VHOG:0000490", "ZFA:0001071" ; oboInOwl:hasExactSynonym "future neural retina", "future retinal neural layer", "inner layer optic cup", "optic cup inner layer", "presumptive retinas" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future NR", "future neural epithelium", "future neural layer", "presumptive retina" ; oboInOwl:id "UBERON:0005425" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "presumptive neural retina" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003902 ] ) ] . obo:UBERON_0005426 obo:IAO_0000115 "Portion of tissue that gives rise to the lens." ; obo:UBPROP_0000001 "A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG]" ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" ; obo:UBPROP_0000011 "the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals" ; oboInOwl:hasDbXref "EHDAA2:0000983", "EHDAA:4737", "EMAPA:17163", "SCTID:361510002", "TAO:0002205", "VHOG:0001163", "ZFA:0001679" ; oboInOwl:hasNarrowSynonym "hollow lens vesicle", "solid lens vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "immature lens", "lens mass", "presumptive lens" ; oboInOwl:id "UBERON:0005426" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "lens vesicle" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003073 ] . obo:UBERON_0005427 obo:IAO_0000115 "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." ; oboInOwl:hasDbXref "TAO:0002188", "ZFA:0001688" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005427" ; a owl:Class ; rdfs:label "corneal primordium" ; rdfs:subClassOf obo:UBERON_0000479, obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ], _:genid141014 . obo:UBERON_0005428 obo:IAO_0000115 "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." ; obo:UBPROP_0000001 "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives.[TAO]" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; obo:UBPROP_0000008 "In chicken fate mapping studies it was found to originate from neural crest residing between Somite 1-7 (S1-7); In mouse it is considered to be derived from rhombencephalic (post otic) neural crest cells and trunk neural crest cells (anterior to S5)" ; oboInOwl:hasDbXref "EHDAA2:0002156", "EHDAA:669", "TAO:0000818", "VHOG:0001208", "XAO:0004191", "ZFA:0000818" ; oboInOwl:hasExactSynonym "VNC" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "enteric neural crest", "post-otic neural crest" ; oboInOwl:id "UBERON:0005428" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "vagal neural crest" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ] . obo:UBERON_0005430 obo:IAO_0000115 "A loop of nerves that are part of the cervical plexus that lies superficial to the internal jugular vein in the carotid sheath. Branches from the ansa cervicalis innervate three of the four infrahyoid muscles, including the sternohyoid muscle, the sternothyroid muscle, and the omohyoid muscle." ; oboInOwl:hasDbXref "BAMS:ancer", "EHDAA2:0000124", "EHDAA:6669", "FMA:55142", "SCTID:362474000", "Wikipedia:Ansa_cervicalis" ; oboInOwl:hasExactSynonym "ansa cervicalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ansa hypoglossi" ; oboInOwl:id "UBERON:0005430" ; a owl:Class ; rdfs:label "ansa cervicalis" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003725 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008523 ], _:genid141027 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png"^^xsd:anyURI . obo:UBERON_0005432 obo:IAO_0000115 "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates." ; obo:UBPROP_0000001 "the merged ventral aortae of the embryo which supplies blood to the aortic arches[TMD][http://medical-dictionary.thefreedictionary.com/aortic+sac]." ; oboInOwl:hasDbXref "EHDAA2:0004145", "EHDAA:9826", "EMAPA:36461", "FMA:71008", "RETIRED_EHDAA2:0000133", "SCTID:361527005" ; oboInOwl:hasExactSynonym "saccus aorticus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005432" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aortic sac" ; rdfs:subClassOf obo:UBERON_0001637, obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid139673, _:genid141035 . obo:UBERON_0005434 oboInOwl:hasDbXref "FMA:24219", "SCTID:123958008" ; oboInOwl:hasExactSynonym "cervical region", "neck subdivision", "region of neck", "subdivision of neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005434" ; a owl:Class ; rdfs:label "cervical region" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] . obo:UBERON_0005436 obo:IAO_0000115 "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:." ; oboInOwl:hasDbXref "EHDAA2:0000308", "EHDAA:8570", "EMAPA:37206", "FMA:14771", "MA:0003094", "SCTID:244263001", "Wikipedia:Common_hepatic_artery", "galen:CommonHepaticArtery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria hepatica communis", "common hepatic" ; oboInOwl:id "UBERON:0005436" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "common hepatic artery" ; rdfs:subClassOf obo:UBERON_0004573, _:genid139684 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png"^^xsd:anyURI . obo:UBERON_0005438 obo:IAO_0000115 "The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice." ; obo:UBPROP_0000010 "The sinus, before entering the auricle, is considerably dilated - nearly to the size of the end of the little finger. Its wall is partly muscular, and at its junction with the great coronary vein is somewhat constricted and furnished with a valve consisting of two unequal segments" ; oboInOwl:hasDbXref "EHDAA2:0000320", "EHDAA:9884", "EMAPA:37836", "FMA:4706", "MESH:D054326", "NCIT:C32378", "SCTID:244386006", "UMLS:C0456944", "Wikipedia:Coronary_sinus" ; oboInOwl:hasExactSynonym "sinus coronarius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sinus coronarius" ; oboInOwl:id "UBERON:0005438" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "coronary sinus" ; rdfs:subClassOf obo:UBERON_0003920, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004581 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002078 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray491.png"^^xsd:anyURI . obo:UBERON_0005440 obo:IAO_0000115 "A fetal blood vessel connecting the pulmonary artery with the descending aorta[MESH]. In the developing fetus, the ductus arteriosus is a shunt connecting the pulmonary artery to the aortic arch. It allows most of the blood from the right ventricle to bypass the fetus' fluid-filled lungs, protecting the lungs from being overworked and allowing the left ventricle to strengthen. There are two other fetal shunts, the ductus venosus and the foramen ovale[MP]. the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth[MP]." ; obo:UBPROP_0000001 "The temporary channel or blood vessel between the aorta and pulmonary artery in the fetus. [TFD][VHOG]" ; obo:UBPROP_0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0002515", "EHDAA2:0000420", "EHDAA:6462", "EMAPA:17858", "FMA:79871", "MA:0001947", "MESH:D004373", "NCIT:C52854", "SCTID:253684002", "UMLS:C0013273", "VHOG:0000923", "Wikipedia:Ductus_arteriosus", "galen:DuctusArteriosus" ; oboInOwl:hasExactSynonym "ductus Botallo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Botallo's duct", "arterial canal", "arterial duct", "ductus arteriosis", "ductus arteriosum", "ductus botalli", "ductus layton", "fetal ductus arteriosus" ; oboInOwl:id "UBERON:0005440" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "ductus arteriosus" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004571 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011695 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002012 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0003123 ], _:genid141059, _:genid141065 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png"^^xsd:anyURI . obo:UBERON_0005442 obo:IAO_0000115 "The lateral abdominal wall muscle that is the most superficial, immediately superficial to the internal oblique." ; obo:UBPROP_0000003 "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000469", "EHDAA:8248", "EMAPA:18162", "FMA:13335", "MA:0002345", "NCIT:C32567", "SCTID:244946005", "UMLS:C0224375", "VHOG:0000788", "Wikipedia:Abdominal_external_oblique_muscle" ; oboInOwl:hasExactSynonym "abdominal external oblique muscle", "external abdominal oblique muscle", "external oblique", "external oblique muscle", "obliquus externus abdominis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external abdominal oblique", "external abdominal oblique muscle", "external oblique", "external oblique abdominal muscles", "external oblique abdominis", "external oblique abdominis muscle", "m. obliquus externus abdominis", "oblique strength", "obliquus abdominis externus", "obliquus externus", "obliquus externus abdominis", "obliquus externus abdominis muscle" ; oboInOwl:id "UBERON:0005442" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim ; a owl:Class ; rdfs:label "abdominal external oblique muscle" ; rdfs:subClassOf obo:UBERON_0035032, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002228 ], _:genid141086, _:genid141089, _:genid141091 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0015014 ; owl:someValuesFrom obo:UBERON_0005454 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/32/Illu_trunk_muscles.jpg"^^xsd:anyURI . obo:UBERON_0005445 obo:IAO_0000115 "A segment of autopod that is part of a pes." ; oboInOwl:hasBroadSynonym "foot region" ; oboInOwl:hasDbXref "FMA:24993", "SCTID:362887000" ; oboInOwl:hasExactSynonym "foot subdivision", "regio pedis", "segment of foot", "subdivision of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005445" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "segment of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0005446 obo:IAO_0000115 "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa." ; obo:UBPROP_0000001 "A circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.vity. [Wikipedia:Foramen_rotundum][VHOG]" ; obo:UBPROP_0000003 "It is suggested that the mammalian lamina ascendens arose from an upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts, separating foramen rotundum from foramen ovale.[well established][VHOG]" ; obo:UBPROP_0000012 "todo - check placement of AAO class" ; oboInOwl:hasDbXref "AAO:0000194", "EHDAA2:0000552", "EHDAA:10629", "EMAPA:18712", "FMA:53154", "SCTID:369439002", "VHOG:0001543", "Wikipedia:Foramen_rotundum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramen rotundum of the skull", "foramen rotundum ossis sphenoidalis", "round foramen" ; oboInOwl:id "UBERON:0005446" ; a owl:Class ; rdfs:label "foramen rotundum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0000377 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png"^^xsd:anyURI . obo:UBERON_0005451 obo:IAO_0000115 "A segment of autopod that is part of a manus." ; oboInOwl:hasBroadSynonym "hand region" ; oboInOwl:hasDbXref "FMA:24945", "SCTID:127950000" ; oboInOwl:hasExactSynonym "hand subdivision", "regio manus", "segment of hand", "subdivision of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005451" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "segment of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012139 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0005454 obo:IAO_0000115 "The lateral abdominal wall muscle that is deep to the external oblique and superficial to the transversus." ; obo:UBPROP_0000003 "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000879", "EHDAA:8250", "EMAPA:18163", "FMA:13891", "MA:0002346", "NCIT:C32857", "SCTID:244947001", "UMLS:C1512878", "VHOG:0000789", "Wikipedia:Abdominal_internal_oblique_muscle" ; oboInOwl:hasExactSynonym "abdominal internal oblique muscle", "internal oblique", "obliquus internus abdominis", "obliquus internus abdominis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal internal oblique", "internal abdominal oblique", "internal abdominal oblique muscle", "internal oblique abdominal", "internal oblique abdominis", "internal oblique abdominis muscle", "internal oblique muscle", "musculus obliquus internus abdominis", "obliqui internus", "obliquus internus", "obliquus internus abdominis", "obliquus internus abdominis muscle" ; oboInOwl:id "UBERON:0005454" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "abdominal internal oblique muscle" ; rdfs:subClassOf obo:UBERON_0035032, _:genid141154, _:genid141156, _:genid141158 ; owl:equivalentClass _:genid139780 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/32/Illu_trunk_muscles.jpg"^^xsd:anyURI . obo:UBERON_0005456 obo:IAO_0000115 "The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side." ; obo:UBPROP_0000001 "Large foramen that houses the glossopharyngeal and vagus nerves and is located inside the condyloid fossa.[AAO]", "One of a pair of openings between the lateral part of the occipital bone and the petrous part of the temporal bones in the skull. The foramen contains the inferior petrosal sinus; the transverse sinus; some meningeal branches of the occipital and ascending pharyngeal arteries; and the glossopharyngeal, vagus, and accessory nerves. [Free_Online_Medical_Dictionary]" ; obo:UBPROP_0000002 "relationship loss: subclass braincase and otic capsule opening (AAO:0000051)[AAO]" ; oboInOwl:hasDbXref "AAO:0000249", "EHDAA2:0000893", "EHDAA:10631", "EMAPA:18713", "FMA:56432", "MESH:D000080869", "NCIT:C12496", "SCTID:361735006", "UMLS:C0222712", "VHOG:0001113", "Wikipedia:Jugular_foramen" ; oboInOwl:hasExactSynonym "Posterior lacerate foramen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramen jugulare" ; oboInOwl:id "UBERON:0005456" ; a owl:Class ; rdfs:label "jugular foramen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001586 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001649 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001759 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0002019 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001586 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Foramenjugulare.PNG"^^xsd:anyURI . obo:UBERON_0005457 obo:IAO_0000115 "A thymus lobe that is in the left side of a thymus." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:71195", "RETIRED_EHDAA2:0000964", "SCTID:188079002" ; oboInOwl:hasExactSynonym "left lobe of thymus", "left thymic lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005457" ; a owl:Class ; rdfs:label "left thymus lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005483 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0005460 obo:IAO_0000115 "A vitelline vein that is in the left side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0000971", "EMAPA:16380", "EMAPA:16698", "FMA:70307", "SCTID:361446008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005460" ; a owl:Class ; rdfs:label "left vitelline vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005487 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0005461 obo:IAO_0000115 "An axial muscle that originates in the cervical vertebraae inserts on the scapula." ; oboInOwl:hasDbXref "AAO:0010689", "EHDAA2:0000992", "EHDAA:8309", "FMA:32519", "SCTID:279236008", "Wikipedia:Levator_scapulae_muscle" ; oboInOwl:hasExactSynonym "levator scapulae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "levator scapula", "levator scapulae muscle", "levator scapulæ", "musculus levator scapulae" ; oboInOwl:id "UBERON:0005461" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "Axial muscle group[Kardong]" ; rdfs:label "levator scapulae muscle" ; rdfs:subClassOf obo:UBERON_0001482, _:genid141214, _:genid141216, _:genid141218, _:genid141220, _:genid141222, _:genid141224 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002413 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bc/Levator_scapulae.png"^^xsd:anyURI . obo:UBERON_0005462 obo:IAO_0000115 "Subdivision of abdominal segment of trunk which in humans is demarcated from the front of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the front of the abdomen, it constitutes the abdomen[Modified from FMA]." ; obo:UBPROP_0000007 "lumbar" ; oboInOwl:hasBroadSynonym "lumbar region" ; oboInOwl:hasDbXref "BTO:0001505", "EMAPA:36623", "FMA:61681", "MA:0000027", "NCIT:C34004", "SCTID:182343007", "UMLS:C0024090" ; oboInOwl:hasExactSynonym "abdominal back", "back of abdomen", "dorsum of abdomen", "lower back", "lumbar part of back", "lumbar region of back", "posterior part of abdomen", "regio lumbalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "loin", "lombus", "lumbos" ; oboInOwl:id "UBERON:0005462" ; a owl:Class ; rdfs:comment "overlaps with region sometimes called 'loin'" ; rdfs:label "lower back" ; rdfs:subClassOf obo:UBERON_0009569, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], _:genid141233 . obo:UBERON_0005463 obo:IAO_0000115 "A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae." ; oboInOwl:hasBroadSynonym "marginal sinus" ; oboInOwl:hasDbXref "EMAPA:37662", "FMA:312355", "MA:0003027", "NCIT:C33033", "NCIT:C33642", "UMLS:C1518051", "UMLS:C1518052", "Wikipedia:Subcapsular_sinus" ; oboInOwl:hasExactSynonym "lymph node subcortical sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph path", "lymph sinus", "marginal sinus of lymph node", "subcapsular sinus" ; oboInOwl:id "UBERON:0005463" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "subcapsular sinus of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002006 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002194 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray597.png"^^xsd:anyURI . obo:UBERON_0005465 obo:IAO_0000115 "The obturator nerve arises from the ventral divisions of the second, third, and fourth lumbar nerves; the branch from the third is the largest, while that from the second is often very small." ; oboInOwl:hasDbXref "EHDAA2:0001282", "EHDAA:5657", "FMA:16487", "MESH:D009776", "NCIT:C75909", "SCTID:181052006", "UMLS:C0028783", "Wikipedia:Obturator_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervus obturatorius" ; oboInOwl:id "UBERON:0005465" ; a owl:Class ; rdfs:label "obturator nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001815 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000376 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray344.png"^^xsd:anyURI . obo:UBERON_0005467 obo:IAO_0000115 "The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve. It attaches to the mandible and it attaches to the skin of the head, neck, and thoracic region where it is found superficial to the clavicle. Burrows et al. (2011) argue that in hylobatids (and, presumably, other primates) the platysma in the region of the modiolus represents both the cervicale and myoides muscles." ; obo:UBPROP_0000001 "The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve, and attaches to the skin.[FEED]" ; obo:UBPROP_0000003 "One of these (facial muscles in mammals), the platysma, is an unspecialized muscle derived from the hyoid arch.[well established][VHOG]" ; oboInOwl:hasDbXref "BTO:0005124", "EHDAA2:0001474", "EHDAA:8270", "EMAPA:18190", "FMA:45738", "MA:0003026", "MFMO:0000059", "NCIT:C33329", "SCTID:244754004", "UMLS:C1514163", "VHOG:0000931", "Wikipedia:Platysma_muscle" ; oboInOwl:hasExactSynonym "platysma muscle" ; oboInOwl:hasNarrowSynonym "platysma cervicale", "platysma myoides" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neck platysma muscle" ; oboInOwl:id "UBERON:0005467" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Human variation notes: Variations occur in the extension over the face and over the clavicle and shoulder; it may be absent or interdigitate with the muscle of the opposite side in front of the neck; attachment to clavicle, mastoid process or occipital bone occurs. A more or less independent fasciculus, the occipitalis minor, may extend from the fascia over the trapezius to fascia over the insertion of the sternocleidomastoideus." ; rdfs:label "platysma" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/472"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0001577, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008876 ], _:genid141272, _:genid141274, _:genid141276, _:genid141278 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Platysma.png"^^xsd:anyURI . obo:UBERON_0005469 obo:IAO_0000115 "A thymus lobe that is in the right side of a thymus." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:71194", "RETIRED_EHDAA2:0001758", "SCTID:187981000" ; oboInOwl:hasExactSynonym "right lobe of thymus", "right thymic lobe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005469" ; a owl:Class ; rdfs:label "right thymus lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005483 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0005472 obo:IAO_0000115 "A vitelline vein that is in the right side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0001766", "EMAPA:16381", "EMAPA:16699", "FMA:70306", "SCTID:361445007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005472" ; a owl:Class ; rdfs:label "right vitelline vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005487 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0005473 obo:IAO_0000115 "A subdivision of an organism along the anterior-posterior axis in the pelvic region immediately posterior to the lumbar region and anterior to the caudal region. Sometimes an intermediate region is defined between the sacral and caudal." ; obo:UBPROP_0000007 "pygal", "sacral" ; obo:UBPROP_0000008 "Amphibians - 1 sacral vertebra; Living reptiles & most birds - 2 sacral vertebrae; Most mammals - 3 to 5 sacral vertebrae. TODO - split sacral from sacrococcygeal" ; oboInOwl:hasDbXref "FMA:24228", "SCTID:182344001", "Wikipedia:Sacrum" ; oboInOwl:hasExactSynonym "back of pelvis", "pelvic back", "posterior part of pelvis", "regio sacralis", "sacral part of pelvis" ; oboInOwl:hasNarrowSynonym "croup", "hindquarter", "rump" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005473" ; a owl:Class ; rdfs:label "sacral region" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0006075 ] . obo:UBERON_0005475 obo:IAO_0000115 "A portion of the lateral venous sinus, bulging prominently into the mastoid cavity, that serves as a principal conduit by which blood leaves the cranium[EPIC]. The sigmoid is drained by the internal jugular vein." ; obo:UBPROP_0000001 "The sigmoid sinuses, within a human head, are 2 areas beneath the brain, which allow blood veins to span the area, from the center of the head downward. They drain from the transverse sinuses (under the back of the brain) to the internal jugular vein. Each sigmoid sinus begins beneath the temporal bone and follows a tortuous course to the jugular foramen, at which point the sinus becomes continuous with the internal jugular vein[Wikipedia:Sigmoid_sinus]." ; oboInOwl:hasDbXref "EHDAA2:0001838", "EHDAA:9880", "EMAPA:19060", "FMA:50782", "SCTID:279264003", "VHOG:0001337", "Wikipedia:Sigmoid_sinus", "ncithesaurus:Sigmoid_Sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sulcus sigmoideus" ; oboInOwl:id "UBERON:0005475" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sigmoid sinus" ; rdfs:subClassOf obo:UBERON_0017635, _:genid139931, _:genid141313 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif"^^xsd:anyURI . obo:UBERON_0005476 obo:IAO_0000115 "Trunk part of spinal nerve, where dorsal and ventral roots meet to form the spinal nerve, before branching off to dorsal and ventral rami." ; oboInOwl:hasDbXref "EHDAA2:0001900", "FMA:5929" ; oboInOwl:hasExactSynonym "spinal nerve (trunk)", "spinal neural trunk", "trunk of spinal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005476" ; a owl:Class ; rdfs:label "spinal nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001780 ] ) ] . obo:UBERON_0005478 obo:IAO_0000115 "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]." ; oboInOwl:hasBroadSynonym "sulcus limitans" ; oboInOwl:hasDbXref "BAMS:slim", "BAMS:slm", "neuronames:629" ; oboInOwl:hasExactSynonym "neural tube lateral wall sulcus limitans" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005478" ; a owl:Class ; rdfs:label "sulcus limitans of neural tube" ; rdfs:subClassOf obo:UBERON_0006846, _:genid141326 . obo:UBERON_0005483 obo:IAO_0000115 "Either of the two lateral lobes that constitute the thymus." ; obo:UBPROP_0000010 "each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. Each lobe is composed of numerous lobules held together by delicate areolar tissue; the entire organ being enclosed in an investing capsule of a similar but denser structure. The primary lobules vary in size from that of a pin's head to that of a small pea, and are made up of a number of small nodules or follicles.[WP]" ; oboInOwl:hasDbXref "FMA:71193", "RETIRED_EHDAA2:0002021" ; oboInOwl:hasExactSynonym "lateral lobe of thymus", "lobe of thymus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005483" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thymus lobe" ; rdfs:subClassOf _:genid141334 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0005484 obo:IAO_0000115 "A valve leaflet that is part of a tricuspid valve." ; obo:UBPROP_0000001 "Leaf of caridac valve which has as its parts the anterior, posterior and septal leaflets that is is attached to the chorda tendinea of the right ventricle and the fibrous ring of tricuspid valve." ; obo:UBPROP_0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18630", "FMA:7237", "MA:0003180", "RETIRED_EHDAA2:0002082", "SCTID:276830008", "VHOG:0000821" ; oboInOwl:hasExactSynonym "leaflet of tricuspid valve", "tricuspid valve leaflet", "tricuspid valve leaflets", "tricuspid valvular leaflet" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005484" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tricuspid valve leaflet" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014851 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011741 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002134 ] ) ] . obo:UBERON_0005486 obo:IAO_0000115 "A venous channel found between layers of dura mater in the brain. Receives blood from internal and external veins of the brain, receive cerebrospinal fluid (CSF) from the subarachnoid space, and ultimately empty into the internal jugular vein." ; obo:IAO_0000116 "the MA placement should be checked" ; oboInOwl:hasDbXref "EHDAA2:0002169", "EHDAA:6491", "EMAPA:18634", "FMA:50762", "MA:0002113", "NCIT:C102627", "SCTID:54944003", "VHOG:0001004", "Wikipedia:Dural_venous_sinuses" ; oboInOwl:hasExactSynonym "cranial dural venous sinus", "dural sinus", "dural vein", "dural venous sinus", "venous dural", "venous dural sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "s. durae matris" ; oboInOwl:id "UBERON:0005486" ; a owl:Class ; rdfs:label "venous dural sinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010743 ], _:genid141355 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006615 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002363 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif"^^xsd:anyURI . obo:UBERON_0005487 obo:IAO_0000115 "The paired veins that carry blood from the yolk sac back to the embryo." ; obo:UBPROP_0000001 "One of two veins that run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.[XAO]" ; obo:UBPROP_0000003 "Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG]" ; obo:UBPROP_0000012 "check zfa (no text def). Check vitelline/omphalomesenteric distinction in XAO" ; oboInOwl:hasDbXref "EMAPA:36021", "FMA:70305", "NCIT:C34329", "RETIRED_EHDAA2:0002209", "SCTID:2730004", "SCTID:308832003", "UMLS:C0231091", "VHOG:0000401", "Wikipedia:Vitelline_veins", "XAO:0000376", "XAO:0004147" ; oboInOwl:hasExactSynonym "embryonic vitelline vein", "vascular vitelline network", "vena vitellina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "omphalomesenteric vein", "vein of omphalomesenteric system", "vitelline veins" ; oboInOwl:id "UBERON:0005487" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "vitelline vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004581 ] ; owl:equivalentClass _:genid139982 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png"^^xsd:anyURI . obo:UBERON_0005491 obo:IAO_0000115 "Cranial neural crest which gives rise to the glossopharyngeal ganglion." ; oboInOwl:hasDbXref "EHDAA2:0000714", "EHDAA:660", "TAO:0007066", "ZFA:0007066" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005491" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "glossopharyngeal neural crest" ; rdfs:subClassOf obo:UBERON_0003099 . obo:UBERON_0005492 obo:IAO_0000115 "A blood vessel that is associated with the lens. In mammals, this is transient and normally nourishes the retina, immature lens and primary vitreous of the developing eye." ; obo:IAO_0000116 "we are currently conflating vessel and vasculature - we may wish to split this class - see also vascular plexus term. The ZFA class represents the vasculature" ; oboInOwl:hasDbXref "EHDAA:4735", "TAO:0005046", "VHOG:0000232", "XAO:0004154", "ZFA:0005046" ; oboInOwl:hasExactSynonym "hyaloid blood vessels", "hyaloid vessels" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hyaloid capillary system", "hyaloid vascular system", "hyaloid vasculature" ; oboInOwl:id "UBERON:0005492" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "hyaloid vessel" ; rdfs:subClassOf obo:UBERON_0001981, _:genid141382 . obo:UBERON_0005493 obo:IAO_0000115 "One of a group of muscles used in mastication and swallowing. These muscles are attached to the hyoid bone, which is suspended in the neck and forms the base of the tongue and larynx. The muscles are divided into suprahyoid (superior) or infrahyoid (inferior) groups relative to the bone[WP, generalized]." ; obo:UBPROP_0000003 "Although the zebrafish occupies a rather derived phylogenetic position within actinopterygians and even within teleosts, with respect to the mandibular, hyoid and hypobranchial muscles it seems justified to consider it an appropriate representative of these two groups. Among these muscles, the three with clear homologues in tetrapods and the further three identified in sarcopterygian fish are particularly appropriate for comparisons of results between the actinopterygian zebrafish and the sarcopterygians.[well established][VHOG]" ; obo:UBPROP_0000008 "attachment sites may vary by species; for example, in orangutans, the posterior digastric does not attach to the hyoid, but we may still consider this a (supra)hyoid muscle." ; oboInOwl:hasDbXref "EFO:0003536", "EHDAA2:0000794", "NCIT:C32753", "SCTID:244823009", "TAO:0000521", "UMLS:C0448345", "VHOG:0001494", "ZFA:0000521" ; oboInOwl:hasExactSynonym "hyoid muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005493" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:vertebrate_core ; a owl:Class ; rdfs:label "hyoid muscle" ; rdfs:subClassOf obo:UBERON_0001630, [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0005884 ], _:genid141390, _:genid141392, _:genid141395 . obo:UBERON_0005496 obo:IAO_0000115 "Portion of tissue on the side of the lumen of the neural tube." ; oboInOwl:hasDbXref "EHDAA2:0001257", "EHDAA:2873", "EHDAA:912", "EMAPA:16166", "TAO:0001435", "VHOG:0000513", "ZFA:0001435" ; oboInOwl:hasExactSynonym "lateral wall neural tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005496" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "neural tube lateral wall" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001049 ] . obo:UBERON_0005497 obo:IAO_0000116 "todo - epidermis? todo - track down EHDAA2 class in new release" ; obo:RO_0002171 obo:UBERON_0002346 ; obo:UBPROP_0000003 "In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG]" ; obo:UBPROP_0000011 "After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm." ; oboInOwl:hasDbXref "EFO:0003643", "EHDAA:257", "EMAPA:16074", "RETIRED_EHDAA2:0001273", "TAO:0001178", "VHOG:0001372", "XAO:0004091", "ZFA:0001178" ; oboInOwl:hasExactSynonym "non neural ectoderm" ; oboInOwl:hasNarrowSynonym "epidermal ectoderm", "epithelial ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "surface ectoderm", "ventral ectoderm" ; oboInOwl:id "UBERON:0005497" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998)." ; rdfs:label "non-neural ectoderm" ; rdfs:subClassOf obo:UBERON_0000479, _:genid141405 . obo:UBERON_0005498 obo:IAO_0000115 "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." ; oboInOwl:hasDbXref "EHDAA2:0001512", "EHDAA:424", "EHDAA:436", "EMAPA:16215", "FMA:321916", "SCTID:361522004", "TAO:0000149", "Wikipedia:Primitive_heart_tube", "ZFA:0000149" ; oboInOwl:hasExactSynonym "primitive heart tube" ; oboInOwl:hasNarrowSynonym "early primitive heart tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005498" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "primitive heart tube" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid141414 . obo:UBERON_0005499 obo:IAO_0000115 "Hindbrain segment or neuromere 1." ; obo:UBPROP_0000001 "Hindbrain segment or neuromere. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000111 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "DHBA:12667", "DMBA:16915", "EFO:0003608", "EHDAA2:0001637", "EMAPA:16290", "FMA:295790", "TAO:0001031", "ZFA:0001031" ; oboInOwl:hasExactSynonym "r1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005499" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "rhombomere 1" ; rdfs:subClassOf obo:UBERON_0001892, _:genid141419 . obo:UBERON_0005501 obo:IAO_0000115 "A neural tube lateral wall that is part of a rhombomere." ; oboInOwl:hasDbXref "EMAPA:32819", "EMAPA:35364" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future hindbrain lateral wall" ; oboInOwl:id "UBERON:0005501" ; a owl:Class ; rdfs:label "rhombomere lateral wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140034 ] . obo:UBERON_0005502 oboInOwl:hasDbXref "EMAPA:32824", "EMAPA:35367", "TAO:0001311", "VHOG:0001018", "ZFA:0001311" ; oboInOwl:hasExactSynonym "roof plate rhombomere", "roof plate rhombomere region", "roof plate rhombomeres" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future hindbrain roof plate", "roof plate hindbrain" ; oboInOwl:id "UBERON:0005502" ; a owl:Class ; rdfs:label "rhombomere roof plate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003054 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001892 ] ) ] . obo:UBERON_0005562 obo:IAO_0000115 "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." ; obo:IAO_0000116 "we follow Kardong table 13.1 in having some developmental contribution of pouch 4 in mammals, but this isn't reflected in EHDAA2. Consider adding distinct term for mesenchyme (see EHDAA2), to indicate NC constribution." ; obo:UBPROP_0000001 "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production. Willett et al, 1999.[TAO]" ; obo:UBPROP_0000008 "variability of developmental origin: In fish, thymic primordia are generated by all the pouches except the first. However, in avians the thymus arises from pouches 3 and 4, whereas in humans it is only generated by the third pouch[PMID:16313389] The thymus arises from the second pouch in frogs, 2-6 in cartilaginous fish, 2-3 in reptiles, 3 or 4 in bony fish, birds and mammals. The final number is variable - 5 paired organs in sharks, 4 in caecilians, 3 in urodeles, 1 in many teleost, anurans and many mammals" ; oboInOwl:hasDbXref "EFO:0003622", "EHDAA2:0002023", "EHDAA:2969", "EMAPA:17523", "TAO:0001077", "ZFA:0001077" ; oboInOwl:hasExactSynonym "thymic primordium", "thymic rudiment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005562" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "thymus primordium" ; rdfs:subClassOf obo:UBERON_0000483, obo:UBERON_0001048, _:genid141440, _:genid141442, _:genid141444, _:genid141446 . obo:UBERON_0005563 obo:IAO_0000115 "Cranial neural crest which gives rise to the trigeminal ganglion." ; obo:IAO_0000116 "todo - compare ZFA and EHDAA2 representation" ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003484", "EHDAA2:0002083", "EHDAA:667", "EMAPA:16170", "TAO:0000080", "VHOG:0000269", "ZFA:0000080" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005563" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "trigeminal neural crest" ; rdfs:subClassOf obo:UBERON_0003099, obo:UBERON_0007530, _:genid141456 . obo:UBERON_0005564 obo:IAO_0000115 "Portion of tissue that gives rise to the immature gonad." ; obo:UBPROP_0000001 "Immature reproductive tissue that has not undergone final maturation into either testis or ovary.[TAO]" ; obo:UBPROP_0000008 "this is a very broad grouping class" ; oboInOwl:hasDbXref "EFO:0003651", "EHDAA:5927", "EMAPA:17204", "RETIRED_EHDAA2:0002148", "TAO:0001262", "WBbt:0008366", "ZFA:0001262" ; oboInOwl:hasExactSynonym "future gonad", "gonadal primordium", "primitive gonad", "undifferentiated gonad" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "immature gonad" ; oboInOwl:id "UBERON:0005564" ; oboInOwl:inSubset core:efo_slim, core:grouping_class, core:vertebrate_core ; a owl:Class ; rdfs:label "gonad primordium" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000991 ], _:genid141461 . obo:UBERON_0005565 obo:IAO_0000115 "Cranial neural crest that gives rise to the facio-acoustic ganglion." ; obo:UBPROP_0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000492", "EHDAA:658", "EMAPA:16312", "TAO:0000762", "VHOG:0000268", "ZFA:0000762" ; oboInOwl:hasExactSynonym "facio acoustic neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005565" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "facio-acoustic neural crest" ; rdfs:subClassOf obo:UBERON_0003099, obo:UBERON_0007530, _:genid141472 . obo:UBERON_0005567 obo:IAO_0000115 "A rhombomere lateral wall that is part of a rhombomere 1." ; oboInOwl:hasDbXref "EHDAA2:0001641", "EMAPA:16482", "TAO:0000781", "ZFA:0000781" ; oboInOwl:hasExactSynonym "lateral wall rhombomere 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005567" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "rhombomere 1 lateral wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005501 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005499 ] ) ] . obo:UBERON_0005568 obo:IAO_0000115 "A rhombomere roof plate that is part of a rhombomere 1." ; oboInOwl:hasDbXref "DMBA:16916", "EHDAA2:0001645", "EMAPA:16483", "TAO:0001033", "ZFA:0001033" ; oboInOwl:hasExactSynonym "roof plate rhombomere 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005568" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "rhombomere 1 roof plate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005502 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005499 ] ) ] . obo:UBERON_0005594 obo:IAO_0000115 "Somite located in the head region, caudal to the otic vesicle." ; obo:UBPROP_0000008 "in humans this includes somites 1-4" ; obo:UBPROP_0000011 "They provide the epaxial and hypaxial muscles of the neck, the pharyngeal and laryngeal muscles that develop in the caudal branchial arches and the musculature of the tongue. Despite their localisation in the head, myogenic precursors from occipital somites essentially follow the trunk programmes (E. H. Walters and S. D., unpublished). during evolution, have been secondarily incorporated into the head (Gans and Northcutt, 1983)" ; obo:UBPROP_0000012 "EHDAA2 has both 'head somite' and 'head somite group', with part_of and develops_from for latter" ; oboInOwl:hasDbXref "EHDAA2:0003437", "EMAPA:16172", "XAO:0000313" ; oboInOwl:hasExactSynonym "occipital somite" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial somite" ; oboInOwl:id "UBERON:0005594" ; a owl:Class ; rdfs:label "head somite" ; rdfs:subClassOf _:genid141493, _:genid141495 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002329 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009617 ] ) ] . obo:UBERON_0005597 obo:IAO_0000115 "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." ; oboInOwl:hasDbXref "AAO:0011059", "EFO:0002578", "EMAPA:36007", "XAO:0001002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral diverticula", "lung diverticulum", "lung endoderm" ; oboInOwl:id "UBERON:0005597" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "lung primordium" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008947 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000170 ], _:genid141504 . obo:UBERON_0005598 obo:IAO_0000115 "A somite that is part of a trunk." ; oboInOwl:hasDbXref "AAO:0010385", "EHDAA2:0003438", "EMAPA:16184", "XAO:0000314" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005598" ; a owl:Class ; rdfs:label "trunk somite" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002329 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0005602 obo:IAO_0000115 "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." ; obo:UBPROP_0000001 "The dorsal sheet of the primitive mesentery that encloses the stomach. The greater omentum develops from the dorsal mesogastrium. [TFD][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000416", "EHDAA:3001", "EMAPA:17025", "MA:0001618", "NCIT:C34142", "UMLS:C1512038", "VHOG:0000352", "Wikipedia:Dorsal_mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal mesentery" ; oboInOwl:id "UBERON:0005602" ; a owl:Class ; rdfs:label "dorsal mesogastrium" ; rdfs:subClassOf obo:UBERON_0003281, _:genid141517, _:genid141519 . obo:UBERON_0005604 oboInOwl:hasDbXref "EMAPA:16844", "MA:0001636", "VHOG:0000215" ; oboInOwl:hasExactSynonym "extrahepatic part of the hepatic duct", "hepatic duct extrahepatic part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005604" ; a owl:Class ; rdfs:label "extrahepatic part of hepatic duct" ; rdfs:subClassOf obo:UBERON_0000058, _:genid141525, _:genid141527 . obo:UBERON_0005606 obo:UBPROP_0000001 "A depression in the front of the vitreous body, lodging the lens. [adapted_from_the_definition_of_the_hyaloid_fossa]" ; oboInOwl:hasDbXref "EHDAA2:0000789", "EHDAA:4733", "EMAPA:17302", "FMA:312291", "MA:0000272", "VHOG:0001477" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005606" ; a owl:Class ; rdfs:label "hyaloid cavity" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002203 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000608 ] . obo:UBERON_0005609 obo:IAO_0000115 "Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery." ; obo:IAO_0000232 "this is an extremely loose and flexible grouping class that is the superclass of the mammalian common iliac and its main brahces, together with analagous structures in other tetrapods" ; obo:UBPROP_0000012 "we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific" ; oboInOwl:hasDbXref "BTO:0004665", "EHDAA:2551", "EMAPA:17309", "MA:0001971", "MESH:D007083", "NCIT:C12733", "RETIRED_EHDAA2:0000807", "SCTID:244330006", "UMLS:C0020887", "Wikipedia:Iliac_artery", "XAO:0000361", "galen:IliacArtery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005609" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "iliac artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002355 ] . obo:UBERON_0005610 obo:IAO_0000115 "Any of the three veins including the common, external and internal iliac veins." ; oboInOwl:hasDbXref "EHDAA2:0000811", "EMAPA:37151", "MA:0002142", "MESH:D007084", "NCIT:C12734", "SCTID:281481002", "UMLS:C0020888" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic vein" ; oboInOwl:id "UBERON:0005610" ; a owl:Class ; rdfs:label "iliac vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0010708 ] . obo:UBERON_0005611 obo:IAO_0000115 "A corner of the medial (inner) part of an eye." ; obo:UBPROP_0000001 "The angle at the end of the palpebral fissure, the slit between the eyelids, close to the nose. [ISBN:0124020607, p.263][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000829", "EMAPA:17830", "FMA:59316", "MA:0001262", "NCIT:C49564", "SCTID:362526003", "UMLS:C1708516", "VHOG:0000829" ; oboInOwl:hasExactSynonym "medial palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inner canthi", "medial canthus", "medial canthus of eye", "nasal canthus" ; oboInOwl:id "UBERON:0005611" ; a owl:Class ; rdfs:label "inner canthus" ; owl:disjointWith obo:UBERON_0006726 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006742 [ a owl:Restriction ; owl:onProperty core:in_innermost_side_of ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0005613 obo:UBPROP_0000003 "A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG]" ; obo:UBPROP_0000008 "Contributes to the arch of aorta in humans" ; oboInOwl:hasDbXref "EHDAA2:0000936", "EHDAA:404", "EMAPA:16205", "MA:0000478", "SCTID:361403005", "VHOG:0000484" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005613" ; a owl:Class ; rdfs:label "left dorsal aorta" ; rdfs:subClassOf obo:UBERON_0000947, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005805 ] . obo:UBERON_0005614 obo:IAO_0000115 "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex." ; obo:UBPROP_0000010 "Cells of the subcapsular epithelium (or anterior lens cells) are mitotically active. In adult individuals they only cover the anterior 'hemisphere' of the lens. As they divide, cells gradually move towards the equator of the lens where they tranform into lens fibres. The apical part of the gradually elongating cell extends between the subcapsular epithelium and adjacent lens fibres towards the anterior pole of the lens. The basal part extends towards the posterior pole. The nucleus remains close to the equatorial plane of the lens - http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm" ; oboInOwl:hasBroadSynonym "lens epithelium" ; oboInOwl:hasDbXref "EHDAA2:0000984", "EHDAA:9059", "EMAPA:17304", "EMAPA:17839", "FMA:70612", "MA:0001302", "NCIT:C33641", "RETIRED_EHDAA2:0000976", "SCTID:362521008", "UMLS:C1182652", "VHOG:0001425" ; oboInOwl:hasExactSynonym "lens subcapsular epithelium", "subcapsular lens epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior epithelium of lens vesicle", "anterior surface of lens" ; oboInOwl:id "UBERON:0005614" ; a owl:Class ; rdfs:label "lens anterior epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000389 ], _:genid141564 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001804 ] ) ] . obo:UBERON_0005616 obo:IAO_0000115 "Arteries which arise from the abdominal aorta and distribute to most of the intestines." ; obo:IAO_0000116 "includes posterior and anterior mesenteric arteries, which branch from the dorsal aorta (see Kardong), and superior and inferior mesenteric arteries" ; oboInOwl:hasDbXref "BTO:0000779", "EHDAA2:0001123", "EHDAA:4343", "EMAPA:17312", "MA:0002003", "MESH:D008638", "NCIT:C52975", "SCTID:281084003", "UMLS:C0025465", "VHOG:0001117", "Wikipedia:Mesenteric_artery", "XAO:0000370" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005616" ; a owl:Class ; rdfs:label "mesenteric artery" ; rdfs:subClassOf _:genid141577 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0005617 obo:IAO_0000115 "A vein that returns blood from the intestines." ; obo:UBPROP_0000008 "In humans the inferior mesenteric vein empties into the splenic vein, the superior mesenteric vein joins the splenic vein to form the portal vein" ; oboInOwl:hasDbXref "BTO:0002781", "EHDAA:4442", "EMAPA:17348", "MA:0002177", "MESH:D008642", "NCIT:C53055", "RETIRED_EHDAA2:0001125", "SCTID:304045008", "UMLS:C0025473", "Wikipedia:Mesenteric_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal vein" ; oboInOwl:id "UBERON:0005617" ; a owl:Class ; rdfs:label "mesenteric vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0005619 obo:IAO_0000115 "The outgrowths of the embryonic maxillary prominences that come together during prenatal development to form the secondary palate." ; obo:IAO_0000116 "consider splitting into embryonic/fully formed" ; obo:UBPROP_0000001 "The outgrowths of the embryonic maxillae that come together during prenatal development to form the secondary palate. [TFD][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001364", "EHDAA:9283", "EMAPA:17362", "FMA:295948", "MA:0001581", "VHOG:0000378" ; oboInOwl:hasExactSynonym "lateral palatine process", "palatal shelf", "secondary palatal shelf" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palatal shelves", "palatine shelf" ; oboInOwl:id "UBERON:0005619" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "secondary palatal shelf" ; rdfs:subClassOf obo:UBERON_0010000, _:genid141588, _:genid141590 . obo:UBERON_0005622 obo:UBPROP_0000003 "A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG]" ; obo:UBPROP_0000008 "Normally regresses in humans" ; oboInOwl:hasDbXref "EHDAA2:0001720", "EHDAA:406", "EMAPA:16206", "MA:0000479", "SCTID:361404004", "VHOG:0000485" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005622" ; a owl:Class ; rdfs:label "right dorsal aorta" ; rdfs:subClassOf obo:UBERON_0000947, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005805 ] . obo:UBERON_0005623 obo:IAO_0000115 "The valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk." ; obo:UBPROP_0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" ; obo:UBPROP_0000010 "Lacks chordae tendinae" ; oboInOwl:hasDbXref "EHDAA2:0001823", "EHDAA:4408", "EMAPA:35760", "MA:0002790", "VHOG:0001393" ; oboInOwl:hasExactSynonym "semilunar valve", "semilunar valves" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005623" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "semi-lunar valve" ; rdfs:subClassOf obo:UBERON_0000946 . obo:UBERON_0005624 obo:IAO_0000115 "Artery that supplies blood to the adrenal glands." ; oboInOwl:hasDbXref "EHDAA2:0001965", "EHDAA:8596", "EMAPA:37124", "MA:0001914", "NCIT:C33708", "SCTID:181342004", "Wikipedia:Adrenal_artery", "ncithesaurus:Adrenal_Artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal artery" ; oboInOwl:id "UBERON:0005624" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "suprarenal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] . obo:UBERON_0005625 obo:IAO_0000115 "The cavity formed by the tubotympanic recess epithelium." ; oboInOwl:hasDbXref "EHDAA2:0002095" ; oboInOwl:hasExactSynonym "cavity of tubotympanic recess", "tubotympanic recess cavity", "tubotympanic recess space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tubotympanic recess" ; oboInOwl:id "UBERON:0005625" ; a owl:Class ; rdfs:label "tubotympanic recess lumen" ; rdfs:subClassOf _:genid141616, _:genid141618 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0010020 ] ) ] . obo:UBERON_0005626 obo:IAO_0000115 "Portion of ventral mesentery closest to the stomach." ; obo:UBPROP_0000001 "The mesentery that originates from the ventral side of the peritoneal cavity.[TAO]", "The ventral sheet of the primitive mesentery that encloses the stomach. The lesser omentum develops from the ventral mesogastrium. [TFD][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0002176", "EHDAA:3005", "EMAPA:17026", "MA:0001621", "NCIT:C34327", "TAO:0005133", "UMLS:C1519967", "VHOG:0000351", "ZFA:0005133" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foregut ventral mesentery" ; oboInOwl:id "UBERON:0005626" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:comment "\"The primitive gut is enveloped by a mesentery that has a dorsal and a ventral aspect. The ventral mesentery degenerates during development with the exception of the foregut ventral mesentery, which develops into specialized structures (see foregut embryology).\" [http://sprojects.mmi.mcgill.ca/embryology/gi/pgm.htm]. todo - check" ; rdfs:label "ventral mesogastrium" ; rdfs:subClassOf obo:UBERON_0003281, _:genid141622 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray984.png"^^xsd:anyURI . obo:UBERON_0005629 obo:IAO_0000115 "A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part." ; obo:UBPROP_0000001 "In a vascular plexus, the contents of the vessels mix. A plexus allows blood to flow via multiple routes. If one branch of the plexus is obstructed, the blood may flow via the open branches[Wikipedia:Plexus#Circulatory_system]." ; oboInOwl:hasDbXref "AEO:0000219", "EHDAA2:0004112", "EMAPA:35904", "FMA:5900", "XAO:0004143" ; oboInOwl:hasExactSynonym "plexus vasculosus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005629" ; a owl:Class ; rdfs:label "vascular plexus" ; rdfs:subClassOf obo:UBERON_0002049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001981 ] . obo:UBERON_0005631 obo:IAO_0000115 "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." ; obo:UBPROP_0000008 "stuctures homologous to the four extraembryonic membranes appear in mammals [ISBN:0073040584 (Vertebrates, Kardong)]" ; obo:UBPROP_0000012 "EHDAA2 is a mereological sum." ; oboInOwl:hasDbXref "EHDAA2:0004714", "FMA:305915", "MESH:D005321", "SCTID:362840007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005631" ; a owl:Class ; rdfs:label "extraembryonic membrane" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-extraembryonic-membranes"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004716 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] . obo:UBERON_0005637 obo:IAO_0000115 "An epithelium that is part of a pylorus." ; oboInOwl:hasDbXref "EHDAA2:0001582", "EMAPA:17633", "RETIRED_EHDAA2:0001927" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005637" ; a owl:Class ; rdfs:label "pyloric region epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001166 ] ) ] . obo:UBERON_0005638 obo:IAO_0000115 "An epithelium that is part of a anterior chamber of eyeball." ; oboInOwl:hasDbXref "EHDAA2:0000130" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005638" ; a owl:Class ; rdfs:label "anterior chamber epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001766 ] ) ] . obo:UBERON_0005645 obo:IAO_0000115 "An epithelium that is part of a manual digit 2." ; oboInOwl:hasDbXref "EHDAA2:0000518", "EMAPA:17433" ; oboInOwl:hasExactSynonym "fore limb digit 2 epithelium", "manual digit II epithelium" ; oboInOwl:hasNarrowSynonym "hand digit 2 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005645" ; a owl:Class ; rdfs:label "manual digit 2 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0005646 obo:IAO_0000115 "An epithelium that is part of a manual digit 3." ; oboInOwl:hasDbXref "EHDAA2:0000524", "EMAPA:17436" ; oboInOwl:hasExactSynonym "fore limb digit 3 epithelium", "manual digit III epithelium" ; oboInOwl:hasNarrowSynonym "hand digit 3 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005646" ; a owl:Class ; rdfs:label "manual digit 3 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140245 ] . obo:UBERON_0005647 obo:IAO_0000115 "An epithelium that is part of a manual digit 4." ; oboInOwl:hasDbXref "EHDAA2:0000530", "EMAPA:17439" ; oboInOwl:hasExactSynonym "fore limb digit 4 epithelium", "manual digit IV epithelium" ; oboInOwl:hasNarrowSynonym "hand digit 4 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005647" ; a owl:Class ; rdfs:label "manual digit 4 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0005648 obo:IAO_0000115 "An epithelium that is part of a manual digit 5." ; oboInOwl:hasDbXref "EHDAA2:0000536", "EMAPA:17442" ; oboInOwl:hasExactSynonym "fore limb digit 5 epithelium", "manual digit V epithelium" ; oboInOwl:hasNarrowSynonym "hand digit 5 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005648" ; a owl:Class ; rdfs:label "manual digit 5 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0005649 obo:IAO_0000115 "An epithelium that is part of a pedal digit 2." ; oboInOwl:hasDbXref "EHDAA2:0002043", "EMAPA:17464" ; oboInOwl:hasExactSynonym "hind limb digit 2 epithelium", "pedal digit II epithelium" ; oboInOwl:hasNarrowSynonym "foot digit 2 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005649" ; a owl:Class ; rdfs:label "pedal digit 2 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0005650 obo:IAO_0000115 "An epithelium that is part of a pedal digit 3." ; oboInOwl:hasDbXref "EHDAA2:0002048", "EMAPA:17467" ; oboInOwl:hasExactSynonym "hind limb digit 3 epithelium", "pedal digit III epithelium" ; oboInOwl:hasNarrowSynonym "foot digit 3 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005650" ; a owl:Class ; rdfs:label "pedal digit 3 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0005651 obo:IAO_0000115 "An epithelium that is part of a pedal digit 4." ; oboInOwl:hasDbXref "EHDAA2:0002053", "EMAPA:17470" ; oboInOwl:hasExactSynonym "hind limb digit 4 epithelium", "pedal digit IV epithelium" ; oboInOwl:hasNarrowSynonym "foot digit 4 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005651" ; a owl:Class ; rdfs:label "pedal digit 4 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0005652 obo:IAO_0000115 "An epithelium that is part of a pedal digit 5." ; oboInOwl:hasDbXref "EHDAA2:0002058", "EMAPA:17473" ; oboInOwl:hasExactSynonym "hind limb digit 5 epithelium", "pedal digit V epithelium" ; oboInOwl:hasNarrowSynonym "foot digit 5 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005652" ; a owl:Class ; rdfs:label "pedal digit 5 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0005653 obo:IAO_0000115 "A dental epithelium that is part of a upper jaw molar." ; oboInOwl:hasDbXref "EHDAA2:0002126", "EMAPA:17943" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005653" ; a owl:Class ; rdfs:label "upper jaw molar epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011642 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003843 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003666 ] ) ] . obo:UBERON_0005654 obo:IAO_0000115 "A dental epithelium that is part of a lower jaw molar." ; oboInOwl:hasDbXref "EHDAA2:0001026", "EMAPA:17922" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005654" ; a owl:Class ; rdfs:label "lower jaw molar epithelium" ; rdfs:subClassOf _:genid140310 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003843 _:genid140308 ) ] . obo:UBERON_0005656 obo:IAO_0000115 "An epithelium that is part of a lens vesicle." ; oboInOwl:hasDbXref "EHDAA2:0000987", "EMAPA:17165", "VHOG:0000532" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005656" ; a owl:Class ; rdfs:label "lens vesicle epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005426 ] ) ] . obo:UBERON_0005658 obo:IAO_0000115 "An epithelium that is part of a secondary palatal shelf." ; oboInOwl:hasDbXref "EHDAA2:0001365", "EMAPA:17363", "FMA:312465", "VHOG:0001040" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palatal shelf epithelium" ; oboInOwl:id "UBERON:0005658" ; a owl:Class ; rdfs:label "secondary palatal shelf epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140318 ] . obo:UBERON_0005660 obo:IAO_0000115 "An ectoderm that is part of a pharyngeal arch 2." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000055", "EMAPA:16277", "EMAPA:16397", "EMAPA:16398", "RETIRED_EHDAA2:0000064", "VHOG:0001062" ; oboInOwl:hasExactSynonym "2nd pharyngeal arch ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005660" ; a owl:Class ; rdfs:label "2nd arch ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ] . obo:UBERON_0005661 obo:IAO_0000115 "An ectoderm that is part of a pharyngeal arch 3." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000072", "EMAPA:16400", "EMAPA:16582", "EMAPA:16584", "RETIRED_EHDAA2:0000079", "VHOG:0000946" ; oboInOwl:hasExactSynonym "3rd pharyngeal arch ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005661" ; a owl:Class ; rdfs:label "3rd arch ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0005662 obo:IAO_0000115 "An ectoderm that is part of a pharyngeal arch 4." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0004032", "EMAPA:16762", "EMAPA:16764", "EMAPA:16768", "RETIRED_EHDAA2:0000094", "VHOG:0001095" ; oboInOwl:hasExactSynonym "4th pharyngeal arch ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005662" ; a owl:Class ; rdfs:label "4th arch ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0005664 obo:IAO_0000115 "An endoderm that is part of a pharyngeal arch 2." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000061", "EMAPA:16274", "EMAPA:16276", "EMAPA:16278", "RETIRED_EHDAA2:0000065", "VHOG:0001108" ; oboInOwl:hasExactSynonym "2nd pharyngeal arch endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005664" ; a owl:Class ; rdfs:label "2nd arch endoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ] . obo:UBERON_0005665 obo:IAO_0000115 "An endoderm that is part of a pharyngeal arch 3." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000075", "EMAPA:16401", "EMAPA:16585", "EMAPA:16587", "RETIRED_EHDAA2:0000080", "VHOG:0001081" ; oboInOwl:hasExactSynonym "3rd pharyngeal arch endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005665" ; a owl:Class ; rdfs:label "3rd arch endoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0005666 obo:IAO_0000115 "An endoderm that is part of a pharyngeal arch 4." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0004033", "EMAPA:16765", "EMAPA:16767", "EMAPA:16769", "RETIRED_EHDAA2:0000095", "VHOG:0001092" ; oboInOwl:hasExactSynonym "4th pharyngeal arch endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005666" ; a owl:Class ; rdfs:label "4th arch endoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0005667 oboInOwl:hasDbXref "EHDAA2:0000314" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005667" ; a owl:Class ; rdfs:label "connecting stalk mesoderm" ; rdfs:subClassOf obo:UBERON_0007524, _:genid141778, _:genid141780 . obo:UBERON_0005669 obo:IAO_0000115 "A mesothelium that is part of a peritoneal cavity." ; obo:UBPROP_0000012 "we believe that this corresponds to EMAPA:16139 based on synonyms and parenthood" ; oboInOwl:hasBroadSynonym "peritoneum" ; oboInOwl:hasDbXref "BTO:0003156", "EHDAA2:0001447", "EMAPA:16139", "FMA:18147", "SCTID:34073007" ; oboInOwl:hasExactSynonym "mesothelium of peritoneal component", "mesothelium of peritoneum", "peritoneal mesothelium", "peritoneum mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005669" ; a owl:Class ; rdfs:label "peritoneal cavity mesothelium" ; owl:equivalentClass _:genid140368 . obo:UBERON_0005672 obo:IAO_0000115 "An endothelium that is part of a right lung." ; oboInOwl:hasDbXref "EHDAA2:0001755" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005672" ; a owl:Class ; rdfs:label "right lung endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0005673 obo:IAO_0000115 "An endothelium that is part of a left lung." ; oboInOwl:hasDbXref "EHDAA2:0000961" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005673" ; a owl:Class ; rdfs:label "left lung endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0005685 obo:IAO_0000115 "A dorsal mesentery that is part of a midgut." ; oboInOwl:hasDbXref "EMAPA:16722", "EMAPA:17040", "EMAPA:18671", "RETIRED_EHDAA2:0001187", "SCTID:361434009" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005685" ; a owl:Class ; rdfs:label "midgut dorsal mesentery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002296 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0005687 obo:IAO_0000115 "An orbitosphenoid endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001329", "EHDAA:9554" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sphenoid lesser wing cartilage element" ; oboInOwl:id "UBERON:0005687" ; a owl:Class ; rdfs:label "orbitosphenoid cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, _:genid141813, _:genid141815 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015059 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0005688 obo:IAO_0000115 "An anatomical cavity that is part of a lens vesicle." ; obo:UBPROP_0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "cavity of lens", "lens cavity" ; oboInOwl:hasDbXref "EHDAA2:0000986", "EMAPA:17164", "VHOG:0000531" ; oboInOwl:hasExactSynonym "cavity of lens vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005688" ; a owl:Class ; rdfs:label "lens vesicle cavity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005426 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0005426 ] ) ] . obo:UBERON_0005689 obo:IAO_0000115 "Mesenchyme that is part of a pharyngeal arch 2." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000066", "EHDAA:625", "EMAPA:16279", "FMA:295698", "VHOG:0001102" ; oboInOwl:hasExactSynonym "2nd pharyngeal arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd branchial arch mesenchyme", "pharyngeal arch 2 mesenchyme" ; oboInOwl:id "UBERON:0005689" ; a owl:Class ; rdfs:label "2nd arch mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ] . obo:UBERON_0005690 obo:IAO_0000115 "Mesenchyme that is part of a pharyngeal arch 3." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000081", "EHDAA:1094", "EMAPA:16402", "FMA:295700", "VHOG:0001083" ; oboInOwl:hasExactSynonym "3rd pharyngeal arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd branchial arch mesenchyme", "pharyngeal arch 3 mesenchyme" ; oboInOwl:id "UBERON:0005690" ; a owl:Class ; rdfs:label "3rd arch mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0005691 obo:IAO_0000115 "Mesenchyme that is part of a pharyngeal arch 4." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000096", "EHDAA:1677", "EMAPA:16770", "FMA:295702", "VHOG:0001052" ; oboInOwl:hasExactSynonym "4th pharyngeal arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "4th branchial arch mesenchyme", "pharyngeal arch 4 mesenchyme" ; oboInOwl:id "UBERON:0005691" ; a owl:Class ; rdfs:label "4th arch mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0005692 obo:IAO_0000115 "Mesenchyme that is part of a developing manual digit 2." ; oboInOwl:hasDbXref "EHDAA2:0000519", "EMAPA:17434" ; oboInOwl:hasExactSynonym "fore limb digit 2 mesenchyme", "manual digit II mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit 2 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005692" ; a owl:Class ; rdfs:label "manual digit 2 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0005693 obo:IAO_0000115 "Mesenchyme that is part of a developing manual digit 3." ; oboInOwl:hasDbXref "EHDAA2:0000525", "EMAPA:17437" ; oboInOwl:hasExactSynonym "fore limb digit 3 mesenchyme", "manual digit III mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit 3 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005693" ; a owl:Class ; rdfs:label "manual digit 3 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0005694 obo:IAO_0000115 "Mesenchyme that is part of a developing manual digit 4." ; oboInOwl:hasDbXref "EHDAA2:0000531", "EMAPA:17440" ; oboInOwl:hasExactSynonym "fore limb digit 4 mesenchyme", "manual digit IV mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit 4 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005694" ; a owl:Class ; rdfs:label "manual digit 4 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0005695 obo:IAO_0000115 "Mesenchyme that is part of a developing manual digit 5." ; oboInOwl:hasDbXref "EHDAA2:0000537", "EMAPA:17443" ; oboInOwl:hasExactSynonym "fore limb digit 5 mesenchyme", "manual digit V mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit 5 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005695" ; a owl:Class ; rdfs:label "manual digit 5 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0005696 obo:IAO_0000115 "Mesenchyme that is part of a developing pedal digit 2." ; oboInOwl:hasDbXref "EHDAA2:0002044", "EMAPA:17465" ; oboInOwl:hasExactSynonym "hind limb digit 2 mesenchyme", "pedal digit II mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit 2 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005696" ; a owl:Class ; rdfs:label "pedal digit 2 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0005697 obo:IAO_0000115 "Mesenchyme that is part of a developing pedal digit 3." ; oboInOwl:hasDbXref "EHDAA2:0002049", "EMAPA:17468" ; oboInOwl:hasExactSynonym "hind limb digit 3 mesenchyme", "pedal digit III mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit 3 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005697" ; a owl:Class ; rdfs:label "pedal digit 3 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0005698 obo:IAO_0000115 "Mesenchyme that is part of a developing pedal digit 4." ; oboInOwl:hasDbXref "EHDAA2:0002054", "EMAPA:17471" ; oboInOwl:hasExactSynonym "hind limb digit 4 mesenchyme", "pedal digit IV mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit 4 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005698" ; a owl:Class ; rdfs:label "pedal digit 4 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0005699 obo:IAO_0000115 "Mesenchyme that is part of a developing pedal digit 5." ; oboInOwl:hasDbXref "EHDAA2:0002059", "EMAPA:17474" ; oboInOwl:hasExactSynonym "hind limb digit 5 mesenchyme", "pedal digit V mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit 5 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005699" ; a owl:Class ; rdfs:label "pedal digit 5 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0005700 obo:IAO_0000115 "An odontogenic papilla that is part of a upper jaw molar." ; oboInOwl:hasDbXref "EHDAA2:0002127", "EHDAA:8051", "EMAPA:17944" ; oboInOwl:hasExactSynonym "upper jaw molar dental papilla", "upper molar mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005700" ; a owl:Class ; rdfs:label "upper jaw molar odontogenic papilla" ; rdfs:subClassOf _:genid141917 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003666 ] ) ] . obo:UBERON_0005701 obo:IAO_0000115 "An odontogenic papilla that is part of a lower jaw molar." ; oboInOwl:hasDbXref "EHDAA2:0001027", "EHDAA:8015", "EMAPA:17923" ; oboInOwl:hasExactSynonym "lower jaw molar dental papilla", "lower molar mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005701" ; a owl:Class ; rdfs:label "lower jaw molar odontogenic papilla" ; rdfs:subClassOf _:genid141925 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003667 ] ) ] . obo:UBERON_0005702 obo:IAO_0000115 "Mesenchyme that is part of a optic eminence." ; oboInOwl:hasDbXref "EHDAA:942", "EMAPA:16324", "RETIRED_EHDAA2:0001310", "VHOG:0001073" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005702" ; a owl:Class ; rdfs:label "optic eminence mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004348 ] ) ] . obo:UBERON_0005704 obo:IAO_0000115 "Mesenchyme that is part of a developing secondary palatal shelf." ; oboInOwl:hasDbXref "EHDAA2:0001366", "EHDAA:9287", "EMAPA:17364", "VHOG:0001063" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palatal shelf mesenchyme" ; oboInOwl:id "UBERON:0005704" ; a owl:Class ; rdfs:label "secondary palatal shelf mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005619 ] ) ] . obo:UBERON_0005707 obo:IAO_0000115 "An odontogenic papilla that is part of a upper jaw incisor." ; oboInOwl:hasDbXref "EHDAA2:0002123", "EMAPA:17941" ; oboInOwl:hasExactSynonym "upper incisor mesenchyme", "upper jaw incisor dental papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005707" ; a owl:Class ; rdfs:label "upper jaw incisor odontogenic papilla" ; rdfs:subClassOf _:genid141944 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140523 ] . obo:UBERON_0005708 obo:IAO_0000115 "An odontogenic papilla that is part of a lower jaw incisor." ; oboInOwl:hasDbXref "EHDAA2:0001023", "EMAPA:17920" ; oboInOwl:hasExactSynonym "lower incisor mesenchyme", "lower jaw incisor dental papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005708" ; a owl:Class ; rdfs:label "lower jaw incisor odontogenic papilla" ; rdfs:subClassOf _:genid141952 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003451 ] ) ] . obo:UBERON_0005709 obo:IAO_0000115 "A dental epithelium that is part of a upper jaw incisor." ; oboInOwl:hasDbXref "EHDAA2:0002122", "EMAPA:17940" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005709" ; a owl:Class ; rdfs:label "upper jaw incisor epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011642 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003843 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003450 ] ) ] . obo:UBERON_0005710 obo:IAO_0000115 "A dental epithelium that is part of a lower jaw incisor." ; oboInOwl:hasDbXref "EHDAA2:0001022", "EMAPA:17919" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005710" ; a owl:Class ; rdfs:label "lower jaw incisor epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011642 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003843 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003451 ] ) ] . obo:UBERON_0005711 obo:IAO_0000115 "A mesentery of duodenum that is part of a foregut." ; oboInOwl:hasDbXref "EHDAA2:0000564" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005711" ; a owl:Class ; rdfs:label "foregut duodenum mesentery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011642 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003397 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 ] ) ] . obo:UBERON_0005712 obo:IAO_0000115 "A mesentery of duodenum that is part of a midgut." ; oboInOwl:hasDbXref "EHDAA2:0001193" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005712" ; a owl:Class ; rdfs:label "midgut duodenum mesentery" ; rdfs:subClassOf _:genid140558 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003397 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0005719 obo:IAO_0000115 "An apical ectodermal ridge that is part of a footplate." ; oboInOwl:hasDbXref "EHDAA2:0000547", "EMAPA:17251" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005719" ; a owl:Class ; rdfs:label "footplate apical ectodermal ridge" ; rdfs:subClassOf _:genid141984 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004356 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006871 ] ) ] . obo:UBERON_0005720 obo:IAO_0000115 "A venous system that is part of a hindbrain." ; oboInOwl:hasDbXref "EHDAA2:0000776", "EMAPA:18632", "VHOG:0001322" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rhombencephalon venous system" ; oboInOwl:id "UBERON:0005720" ; a owl:Class ; rdfs:label "hindbrain venous system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140567 ] . obo:UBERON_0005721 obo:IAO_0000115 "A mesoderm that has the potential to develop into a pronephros." ; obo:UBPROP_0000001 "Portion of tissue that consists of the mesenchymal precursor to the pronephric kidney and that begins to separate from the intermediate mesoderm at NF stage 21 and epithelializes by NF stage 30.[AAO]" ; oboInOwl:hasDbXref "AAO:0011090", "EFO:0003479", "TAO:0000067", "VHOG:0001239", "XAO:0000264", "ZFA:0000067" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pronephric anlage", "pronephric bulge", "pronephric mesenchyme", "pronephric primordium" ; oboInOwl:id "UBERON:0005721" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "the intermediate mesoderm of the chick embryo acquires its ability to form kidneys through its interactions with the paraxial mesoderm [ISBN:9780878932504 \"Developmental Biology\", PMID:10720431 \"Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm\"]. These interactions induce the expression of TFs including Lim1, Pax2 and Pax6 that cause the intermediate mesoderm to form the kidney" ; rdfs:label "pronephric mesoderm" ; rdfs:subClassOf _:genid141997, _:genid141999 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000926 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:UBERON_0005724 obo:IAO_0000115 "A tissue that is part of a spinal cord and is part of a roof plate." ; obo:UBPROP_0000001 "Roof plate that is part of the spinal cord. [Bgee_curator][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0005246" ; oboInOwl:hasDbXref "EMAPA:17586", "TAO:0001177", "VHOG:0000777", "XAO:0000022", "ZFA:0001177" ; oboInOwl:hasExactSynonym "roof plate spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "roofplate spinal cord", "spinal cord roof" ; oboInOwl:id "UBERON:0005724" ; a owl:Class ; rdfs:label "roof plate spinal cord region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 _:genid140586 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003054 ] ) ] . obo:UBERON_0005725 obo:IAO_0000115 "A sensory system that is capable of olfaction (the sensory perception of smell)." ; obo:IAO_0000116 "consider splitting into main and accessory. See also: vomeronasal organ", "we make the relationship to nervous system 'overlaps', as the olfactory system includes e.g. apertures in the cranium that are not part of the nervous system" ; obo:UBPROP_0000001 "The olfactory system is the sensory system used for olfaction, or the sense of smell. Most mammals and reptiles have two distinct parts to their olfactory system: a main olfactory system and an accessory olfactory system. The main olfactory system detects volatile, airborne substances, while the accessory olfactory system senses fluid-phase stimuli. Behavioral evidence indicates that most often, the stimuli detected by the accessory olfactory system are pheromones. The olfactory system is often spoken of along with the gustatory system as the chemosensory senses because both transduce chemical signals into perception[WP][Wikipedia:Olfactory_system].", "The sensory system used for olfaction (the sense of smell).[AAO]" ; obo:UBPROP_0000008 "In mammals, the main olfactory system detects odorants that are inhaled through the nose, where they contact the main olfactory epithelium, which contains various olfactory receptors. These olfactory receptors are membrane proteins of bipolar olfactory receptor neurons in the olfactory epithelium. Rather than binding specific ligands like most receptors, olfactory receptors display affinity for a range of odor molecules. Olfactory neurons transduce receptor activation into electrical signals in neurons. The signals travel along the olfactory nerve, which belongs to the peripheral nervous system. This nerve terminates in the olfactory bulb, which belongs to the central nervous system. The complex set of olfactory receptors on different olfactory neurons can distinguish a new odor from the background environmental odors and determine the concentration of the odor[WP]." ; oboInOwl:hasDbXref "AAO:0000334", "AAO:0000978", "BILA:0000144", "EFO:0001973", "EMAPA:36004", "FMA:7190", "MA:0002445", "NCIT:C94501", "NLXANAT:090806", "SCTID:362290002", "TAO:0001149", "UMLS:C0228065", "Wikipedia:Olfactory_system", "XAO:0003196", "ZFA:0001149" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005725" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "olfactory system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001016 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002492 ; owl:someValuesFrom obo:UBERON_0000066 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007608 ] ) ] . obo:UBERON_0005726 oboInOwl:hasDbXref "BILA:0000139" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005726" ; oboInOwl:inSubset core:functional_classification ; a owl:Class ; rdfs:label "chemosensory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007606 ] ) ] . obo:UBERON_0005728 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "EHDAA2:0000474", "EMAPA:31862", "EMAPA:31863", "FMA:296719", "VHOG:0000616" ; oboInOwl:hasExactSynonym "extra-embryonic mesoderm", "extraembryonic mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005728" ; a owl:Class ; rdfs:label "extraembryonic mesoderm" ; rdfs:subClassOf obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 ], _:genid142035 . obo:UBERON_0005729 obo:IAO_0000115 "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." ; obo:UBPROP_0000001 "Embryonic region that develops into the pectoral fin bud.[TAO]" ; oboInOwl:hasDbXref "TAO:0001453", "ZFA:0001453" ; oboInOwl:hasExactSynonym "pectoral appendage field of lateral plate mesoderm" ; oboInOwl:hasNarrowSynonym "pectoral fin field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005729" ; a owl:Class ; rdfs:label "pectoral appendage field" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005732 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003413 ] ) ] . obo:UBERON_0005730 obo:IAO_0000115 "A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme." ; obo:UBPROP_0000001 "Embryonic region that develops into the pelvic fin bud.[TAO]" ; oboInOwl:hasDbXref "TAO:0001454", "ZFA:0001454" ; oboInOwl:hasExactSynonym "pelvic appendage field of lateral plate mesoderm" ; oboInOwl:hasNarrowSynonym "pelvic fin field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005730" ; a owl:Class ; rdfs:label "pelvic appendage field" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005732 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003412 ] ) ] . obo:UBERON_0005732 obo:IAO_0000115 "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." ; obo:IAO_0000116 "we represent the field as being a part of the LPM (consistent with ZFA, Gilbert). As a consequence, the relationship between limb bud (with is ectoderm+mesenchyme) stands in a weaker has_developmental_contribution_from relation to the field - TODO implement this." ; oboInOwl:hasExactSynonym "limb/fin field of lateral plate mesoderm", "paired limb/fin field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005732" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "paired limb/fin field" ; rdfs:subClassOf _:genid142056 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007688 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0004357 ] ) ] . obo:UBERON_0005733 obo:IAO_0000115 "A ring of cells capable of forming a limb." ; oboInOwl:hasExactSynonym "limb field of lateral plate mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005733" ; a owl:Class ; rdfs:comment "the central portion of the limb field gives rise to the limb proper. mesenchyme cells proliferate from from the somatic layer of limb field lateral plate mesoderm (limb skeletal precursors) and from the somites (limb muscle precursors) . these mesenchymal cells accumulate under the ectedermal tissue to make a limb bud. // The lateral plate mesoderm in the limb field is also special in that it will induce myoblasts to migrate out from the somites and enter the limb bud. No other region of the lateral plate mesoderm will do that (Hayashi and Ozawa 1995)" ; rdfs:label "limb field" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005732 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0004347 ] ) ] . obo:UBERON_0005734 obo:IAO_0000115 "The outermost layer of a blood vessel, composed mainly of fibrous tissue." ; obo:IAO_0000116 "TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings" ; obo:UBPROP_0000001 "The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]." ; oboInOwl:hasDbXref "BTO:0002010", "EMAPA:36299", "NCIT:C33818", "SCTID:61066005", "UMLS:C0225342", "Wikipedia:Tunica_externa_(vessels)" ; oboInOwl:hasExactSynonym "adventitia externa", "tunica adventitia", "tunica adventitia of vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external coat", "tunica adventitia vasorum", "tunica externa vasorum" ; oboInOwl:id "UBERON:0005734" ; a owl:Class ; rdfs:label "tunica adventitia of blood vessel" ; rdfs:subClassOf obo:UBERON_0004797, obo:UBERON_0005742, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002462 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011824 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg"^^xsd:anyURI . obo:UBERON_0005740 obo:IAO_0000115 "A tunica intima that is part of a artery." ; oboInOwl:hasDbXref "EMAPA:36293", "EV:0100028", "FMA:14272", "SCTID:40022005", "galen:IntimaOfArtery" ; oboInOwl:hasExactSynonym "arterial intima", "tunica interna (intima)(arteriae)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005740" ; a owl:Class ; rdfs:label "tunica intima of artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000415 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002523 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0005742 obo:IAO_0000115 "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." ; oboInOwl:hasDbXref "BTO:0002010", "FMA:45635", "MESH:D063194", "SCTID:30180000", "Wikipedia:Adventitia" ; oboInOwl:hasNarrowSynonym "tunica advetitia", "tunica externa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005742" ; oboInOwl:inSubset core:grouping_class, core:human_reference_atlas ; a owl:Class ; rdfs:label "adventitia" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg"^^xsd:anyURI . obo:UBERON_0005744 obo:IAO_0000115 "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." ; obo:UBPROP_0000012 "in FMA and ZFA this is a conduit space, not a conduit. Note there may be some additional disambiguation required: foramen is used loosely in the sense of any opening (e.g. foramen primum). FMA appears to use cranial conduit (undefined) in the sense of any foramen of the skull (includes mental foramen, which is not in the cranium proper)." ; oboInOwl:hasBroadSynonym "foramen" ; oboInOwl:hasDbXref "AAO:0010438", "TAO:0001736", "VHOG:0001760", "ZFA:0005386" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005744" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "bone foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png"^^xsd:anyURI . obo:UBERON_0005745 obo:IAO_0000115 "An opening in the skull through which cranial nerve II passes.[MP]." ; obo:UBPROP_0000001 "An aperture in the root of the lesser wing of the sphenoid bone transmitting the optic nerve. [TFD][VHOG]", "Foramen in the orbital region of the neurocranium for the passage of the optic nerve (cranial nerve II).[TAO]", "The short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery" ; oboInOwl:hasAlternativeId "UBERON:0006269" ; oboInOwl:hasDbXref "AAO:0000342", "EHDAA2:0001312", "EHDAA:10646", "EMAPA:18716", "FMA:54774", "SCTID:361732009", "TAO:0002025", "VHOG:0001408", "Wikipedia:Optic_canal", "ZFA:0005428" ; oboInOwl:hasExactSynonym "optic canal", "optic foramen", "optic nerve (II) foramen", "optic nerve foramen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis opticus", "foramen opticum ossis sphenoidalis" ; oboInOwl:id "UBERON:0005745" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "In teleost fishes the opening is wider that in mammals. Due to the longer and deeper shape in mammals, this is usually called the optic canal; sometimes the term optic foramen may be used for the opening of the canal, but here we use this term to denote the entire space together with surrounding bone surface." ; rdfs:label "optic foramen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002478 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001619 ], _:genid142101 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0000941 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg"^^xsd:anyURI . obo:UBERON_0005749 obo:IAO_0000115 "The capillary loops of the kidney that normally function as a filtration unit[MP]." ; obo:UBPROP_0000011 "...Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus" ; oboInOwl:hasDbXref "EMAPA:28239", "SCTID:362217000", "Wikipedia:Glomerulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glomerular capillary tuft", "glomerulus" ; oboInOwl:id "UBERON:0005749" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "glomerular tuft" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001230 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0003094 ], _:genid142115 . obo:UBERON_0005753 obo:IAO_0000115 "The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm." ; oboInOwl:hasExactSynonym "caudal portion of nephrogenic cord", "caudal region of nephrogenic cord", "rear part of nephrogenic cord", "rear portion of nephrogenic cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005753" ; a owl:Class ; rdfs:label "caudal part of nephrogenic cord" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004875 ] . obo:UBERON_0005754 obo:IAO_0000115 "The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005754" ; a owl:Class ; rdfs:label "rostral part of nephrogenic cord" ; rdfs:subClassOf obo:UBERON_0005423, _:genid140701, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004875 ] . obo:UBERON_0005764 obo:IAO_0000115 "An acellular anatomical structure that is the bounding layer of a anatomical structure." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FMA:63871" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005764" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "acellular membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000476 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000061 ] ) ] . obo:UBERON_0005769 obo:IAO_0000115 "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." ; obo:IAO_0000232 "this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell." ; obo:RO_0002175 obo:NCBITaxon_80999 ; oboInOwl:hasDbXref "AAO:0010596", "FMA:63872", "GAID:915", "NCIT:C13191", "SCTID:68989006", "UMLS:C0004799", "Wikipedia:Basement_membrane" ; oboInOwl:hasExactSynonym "basement membrane of connective tissue", "membrana basalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basement membrane" ; oboInOwl:id "UBERON:0005769" ; a owl:Class ; rdfs:label "basement membrane of epithelium" ; rdfs:subClassOf obo:UBERON_0005764, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000483 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005587 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:CL_0000066 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0005604 ] . obo:UBERON_0005777 obo:IAO_0000115 "The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter." ; obo:UBPROP_0000001 "Membrane between the mesonephric podocytes and the renal glomerular capillaries. It is a trilaminar structure composed of the fused basement membranes of the glomerular capillaries and basement membrane of the podocytes. The capillary membranes touch the GBM at contact points that are separated by pores. The membrane is semi-permeable allowing water and small molecules to pass into the renal capsular space.[TAO]" ; oboInOwl:hasBroadSynonym "GBM" ; oboInOwl:hasDbXref "EMAPA:28251", "EMAPA:30965", "FMA:74274", "MA:0001659", "MESH:D050533", "NCIT:C32683", "SCTID:243897006", "TAO:0005285", "UMLS:C0599297", "Wikipedia:Glomerular_basement_membrane", "ZFA:0005285" ; oboInOwl:hasExactSynonym "glomerular capillary basement membrane", "glomerular filtration membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005777" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "glomerular basement membrane" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001229 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0003094 ], _:genid142152 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/de/PhysiologieGlom%C3%A9rulaire.png"^^xsd:anyURI . obo:UBERON_0005788 obo:IAO_0000115 "Layer of the glomerular basement membrane adjacent to the glomerular capillary." ; oboInOwl:hasDbXref "FMA:74277", "NCIT:C32920", "TAO:0005287", "UMLS:C1517719", "ZFA:0005287" ; oboInOwl:hasExactSynonym "internal layer of glomerular basement membrane", "lamina interna of glomerular basement membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005788" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "lamina rara interna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001230 ] ) ] . obo:UBERON_0005792 obo:IAO_0000115 "Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions." ; obo:IAO_0000116 "TODO - check ridge vs cord vs nephrogenic cord vs blastema" ; oboInOwl:hasDbXref "EHDAA2:0001242", "EHDAA:1015", "EMAPA:16368", "VHOG:0001240" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nephric cord" ; oboInOwl:id "UBERON:0005792" ; a owl:Class ; rdfs:label "nephric ridge" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004122 ] . obo:UBERON_0005795 oboInOwl:hasDbXref "FMA:72173", "SCTID:255782009" ; oboInOwl:hasExactSynonym "fetal uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005795" ; a owl:Class ; rdfs:label "embryonic uterus" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000995 ] . obo:UBERON_0005800 obo:IAO_0000115 "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." ; oboInOwl:hasDbXref "FMA:13087", "NCIT:C34027", "SCTID:119203005", "UMLS:C0506947" ; oboInOwl:hasExactSynonym "aortic section" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aortic segment", "portion of aorta", "segment of aorta" ; oboInOwl:id "UBERON:0005800" ; a owl:Class ; rdfs:label "section of aorta" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 ] . obo:UBERON_0005805 obo:IAO_0000115 "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." ; obo:UBPROP_0000001 "Each primitive aorta receives anteriorly a vein 'the vitelline vein' from the yolk-sac, and is prolonged backward on the lateral aspect of the notochord under the name of the dorsal aorta. The dorsal aortae give branches to the yolk-sac, and are continued backward through the body-stalk as the umbilical arteries to the villi of the chorion. The two dorsal aortae combine to become the descending aorta in later development[WP].", "Principal unpaired, median artery of the trunk, leading from the paired roots (radices) of the dorsal aorta to the caudal artery. Kimmel et al, 1995.[TAO]", "The artery in vertebrate embryos that transports blood from the aortic arches to the trunk and limbs. In adult fish it is a major artery that carries oxygenated blood from the efferent branchial arteries to branches that supply the body organ. In adult tetrapods it arises from the systemic arch" ; obo:UBPROP_0000002 "relationship loss: part_of axial vasculature (TAO:0001073)[TAO]" ; obo:UBPROP_0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0011029", "BTO:0004673", "EHDAA:402", "EMAPA:18606", "SCTID:338637006", "TAO:0000014", "VHOG:0000264", "Wikipedia:Dorsal_aorta", "XAO:0000051", "ZFA:0000014" ; oboInOwl:hasExactSynonym "DA", "aorta dorsalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aortae dorsales", "dorsal aorta root", "dorsal aortae", "dorsal aortic root", "dorsal aortæ" ; oboInOwl:id "UBERON:0005805" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "dorsal aorta" ; rdfs:subClassOf obo:UBERON_0000947, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002201 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001917 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png"^^xsd:anyURI . obo:UBERON_0005806 obo:IAO_0000115 "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." ; oboInOwl:hasDbXref "FMA:45628", "MESH:D011168", "NCIT:C33344", "SCTID:362063001", "UMLS:C0226727", "Wikipedia:Portal_venous_system" ; oboInOwl:hasExactSynonym "portal venous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005806" ; a owl:Class ; rdfs:label "portal system" ; rdfs:subClassOf obo:UBERON_0002049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 ] . obo:UBERON_0005808 obo:IAO_0000115 "A bone tissue that is part of a long bone." ; oboInOwl:hasDbXref "FMA:83117", "SCTID:425475006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "osseous tissue of long bone" ; oboInOwl:id "UBERON:0005808" ; a owl:Class ; rdfs:label "bone tissue of long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] . obo:UBERON_0005809 obo:IAO_0000115 "The outer or sperficial part of a bone of the manus." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005809" ; a owl:Class ; rdfs:label "cortex of manus bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001439 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005897 ] ) ] . obo:UBERON_0005813 obo:IAO_0000115 "A round nodule, small eminence, or warty outgrowth on an anatomical surface, such as bones, skin, or within the lungs (in the case of tuberculosis). They are also found on the leading edge of Humpback Whale's flippers, improving fluid flow over the flipper's surface[WP]." ; oboInOwl:hasDbXref "AAO:0010605", "BTO:0002173", "FMA:75429", "Wikipedia:Tubercle_(anatomy)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tuber" ; oboInOwl:id "UBERON:0005813" ; oboInOwl:inSubset core:grouping_class, core:upper_level ; a owl:Class ; rdfs:label "tubercle" ; rdfs:subClassOf obo:UBERON_0004529 . obo:UBERON_0005814 obo:IAO_0000115 "A vertebral arch that is part of the first cervical vertebra." ; oboInOwl:hasDbXref "FMA:23975", "SCTID:272708001", "Wikipedia:Arch_of_the_atlas" ; oboInOwl:hasExactSynonym "atlas arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005814" ; a owl:Class ; rdfs:label "arch of atlas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010358 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001092 ] ) ] . obo:UBERON_0005837 obo:IAO_0000115 "A fascicle that is part of a spinal cord." ; oboInOwl:hasDbXref "FMA:75799" ; oboInOwl:hasExactSynonym "spinal cord fasciculus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005837" ; a owl:Class ; rdfs:label "fasciculus of spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001019 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0005838 obo:IAO_0000115 "A fascicle that is part of a brain." ; oboInOwl:hasDbXref "FMA:83844" ; oboInOwl:hasExactSynonym "brain fasciculus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005838" ; a owl:Class ; rdfs:label "fasciculus of brain" ; rdfs:subClassOf _:genid140804 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001019 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0005843 obo:IAO_0000115 "A spinal cord segment that adjacent_to a sacral region." ; oboInOwl:hasDbXref "BIRNLEX:1275", "FMA:256623", "MA:0003085", "NCIT:C12896", "SCTID:244438003", "UMLS:C0581669", "UMLS:C1280196" ; oboInOwl:hasExactSynonym "pars sacralis medullae spinalis", "sacral segment of spinal cord", "sacral segments of spinal cord [1-5]", "segmenta sacralia medullae spinalis [1-5]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005843" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral spinal cord" ; owl:equivalentClass _:genid140807 . obo:UBERON_0005844 obo:IAO_0000116 "This is currently used loosely to refer to cervical, lumbar, etc as well as the metamerically repeated segments, which may correspond more closely with the ZFA neuromere term" ; oboInOwl:hasDbXref "BIRNLEX:2665", "FMA:62420", "MA:0003080", "SCTID:278748001" ; oboInOwl:hasExactSynonym "axial part of spinal cord", "axial regional part of spinal cord", "segment of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spinal neuromeres" ; oboInOwl:id "UBERON:0005844" ; a owl:Class ; rdfs:label "spinal cord segment" ; rdfs:subClassOf obo:UBERON_0000073, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] . obo:UBERON_0005845 obo:IAO_0000115 "A spinal cord segment that adjacent_to a caudal region." ; oboInOwl:hasDbXref "FMA:256635", "MA:0003084", "SCTID:278753006", "neuronames:1656" ; oboInOwl:hasExactSynonym "coccygeal segment of spinal cord", "coccygeal segments of spinal cord [1-3]", "pars coccygea medullae spinalis", "segmenta coccygea medullae spinalis [1-3]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "segmenta coccygea" ; oboInOwl:id "UBERON:0005845" ; a owl:Class ; rdfs:comment "for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned" ; rdfs:label "caudal segment of spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005844 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006071 ] ) ] . obo:UBERON_0005852 obo:IAO_0000115 "A subdivision of spinal cord ventral column that is part of a thoracic spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1448", "UMLS:C0228636", "UMLS:C1288556" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005852" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracic spinal cord ventral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid140834 ] . obo:UBERON_0005853 obo:IAO_0000115 "A subdivision of spinal cord ventral column that is part of a sacral spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1520" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005853" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral spinal cord ventral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005843 ] ) ] . obo:UBERON_0005854 obo:IAO_0000115 "A subdivision of spinal cord ventral column that is part of a cervical spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1660", "UMLS:C0228619", "UMLS:C1278746" ; oboInOwl:hasExactSynonym "cervical spinal cord anterior column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005854" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical spinal cord ventral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002726 ] ) ] . obo:UBERON_0005855 obo:IAO_0000115 "A subdivision of spinal cord ventral column that is part of a lumbar spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:840" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005855" ; a owl:Class ; rdfs:label "lumbar spinal cord ventral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002792 ] ) ] . obo:UBERON_0005856 obo:IAO_0000115 "A delimited region of dense mesenchyme within looser mesenchyme." ; oboInOwl:hasDbXref "AEO:0000148", "EHDAA2_RETIRED:0003148", "EHDAA:8979" ; oboInOwl:hasExactSynonym "mesenchyme condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005856" ; a owl:Class ; rdfs:label "developing mesenchymal condensation" ; rdfs:subClassOf obo:UBERON_0007524, obo:UBERON_0011585, _:genid142288 . obo:UBERON_0005863 obo:IAO_0000115 "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." ; obo:UBPROP_0000012 "isa cell condensation in VSAO; has_part chondroblast in AEO" ; oboInOwl:hasDbXref "AEO:0000147", "EHDAA2_RETIRED:0003147", "EMAPA:32731", "VSAO:0000092", "XAO:0004022" ; oboInOwl:hasExactSynonym "cartilage condensation", "cartilagenous condensation", "chondrogenic condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005863" ; a owl:Class ; rdfs:label "cartilaginous condensation" ; rdfs:subClassOf obo:UBERON_0005856, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005866 ], _:genid142293 . obo:UBERON_0005865 oboInOwl:hasAlternativeId "UBERON:0008714" ; oboInOwl:hasDbXref "AEO:0000149", "EHDAA2_RETIRED:0003149" ; oboInOwl:hasExactSynonym "pre muscle mass", "premuscle mass" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005865" ; a owl:Class ; rdfs:label "pre-muscle condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005090 ], _:genid142305 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005856 _:genid140873 ) ] . obo:UBERON_0005866 obo:IAO_0000115 "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." ; obo:UBPROP_0000001 "A closely packed aggregation of mesenchymal cells just prior to their differentiation into embryonic cartilage." ; oboInOwl:hasDbXref "AEO:0000150", "EHDAA2:0003150", "EMAPA:32736" ; oboInOwl:hasExactSynonym "pre-chondrogenic condensation", "precartilage condensation", "precartilagenous condensation", "prechondrogenic condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005866" ; a owl:Class ; rdfs:label "pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0007844 ], _:genid142310 . obo:UBERON_0005867 obo:IAO_0000115 "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip." ; obo:IAO_0000116 "check develops_from" ; oboInOwl:hasDbXref "EHDAA2:0001061", "EHDAA:5871", "EMAPA:17355", "FMA:293051", "NCIT:C34204", "UMLS:C1512982", "Wikipedia:Mandibular_prominence" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibular process", "mandibular swelling", "prominentia mandibularis" ; oboInOwl:id "UBERON:0005867" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mandibular prominence" ; rdfs:subClassOf obo:UBERON_0012314, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000166 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007237 ] . obo:UBERON_0005868 obo:IAO_0000115 "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw." ; oboInOwl:hasDbXref "EHDAA2:0001070", "EHDAA:5877", "EMAPA:17359", "FMA:293049", "NCIT:C34206", "SCTID:346355001", "UMLS:C1513037", "Wikipedia:Maxillary_prominence" ; oboInOwl:hasExactSynonym "embryonic maxillary process", "maxillary process", "maxillary process of embryo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prominentia maxilaris" ; oboInOwl:id "UBERON:0005868" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "maxillary prominence" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007238 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png"^^xsd:anyURI . obo:UBERON_0005870 obo:IAO_0000115 "An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO]." ; obo:IAO_0000116 "we represent the relationship as develops from, though in fact the pit is formed as an indentation in the placode" ; obo:UBPROP_0000001 "By the upgrowth of the surrounding parts the olfactory areas are converted into pits, the nasal pits or olfactory pits, which indent the fronto-nasal process and divide it into a medial and two lateral nasal processes[Wikipedia:Nasal_pit]." ; oboInOwl:hasDbXref "AAO:0011068", "EFO:0003496", "EHDAA2:0001295", "EHDAA:4772", "EMAPA:16800", "FMA:295840", "SCTID:361485001", "Wikipedia:Nasal_pit", "XAO:0000275", "XAO:0004073" ; oboInOwl:hasExactSynonym "nasal pit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005870" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "olfactory pit" ; rdfs:subClassOf obo:UBERON_0016566, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid142329, _:genid142332, _:genid142334 . obo:UBERON_0005872 obo:IAO_0000115 "A groove that is situated between the 1st and 2nd pharyngeal arch." ; obo:UBPROP_0000003 "In all jawed vertebrates the first arch forms the jaw, while the second arch forms the hyoid apparatus. These two arches are separated by the first pharyngeal pouch and cleft.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000009", "EHDAA:575", "EMAPA:16119", "VHOG:0000554", "VHOG:0000969" ; oboInOwl:hasExactSynonym "1st arch branchial groove", "1st arch groove ectoderm", "1st pharyngeal groove", "1st pharyngeal groove ectoderm", "branchial groove of 1st arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "1st branchial cleft", "1st pharyngeal cleft" ; oboInOwl:id "UBERON:0005872" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "1st arch pharyngeal cleft" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005879 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0004362 ] ) ] . obo:UBERON_0005873 obo:IAO_0000115 "A groove that is situated between the 2nd and 3rd pharyngeal arch." ; oboInOwl:hasDbXref "EHDAA2:0000057", "EHDAA:613", "EMAPA:16396", "VHOG:0000568", "VHOG:0000972" ; oboInOwl:hasExactSynonym "2nd arch branchial groove", "2nd arch groove ectoderm", "2nd pharyngeal groove", "2nd pharyngeal groove ectoderm", "branchial groove of 2nd arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "2nd branchial cleft", "2nd pharyngeal cleft" ; oboInOwl:id "UBERON:0005873" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "2nd arch pharyngeal cleft" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005879 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0005874 obo:IAO_0000115 "A groove that is situated between the 3rd and 4th pharyngeal arch." ; oboInOwl:hasDbXref "EHDAA2:0000074", "EHDAA:1082", "EMAPA:16581", "VHOG:0000572", "VHOG:0000973" ; oboInOwl:hasExactSynonym "3rd arch branchial groove", "3rd arch groove ectoderm", "3rd pharyngeal groove", "3rd pharyngeal groove ectoderm", "branchial groove of 3rd arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "3rd branchial cleft", "3rd pharyngeal cleft" ; oboInOwl:id "UBERON:0005874" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "3rd arch pharyngeal cleft" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005879 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0005876 obo:IAO_0000115 "The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin." ; obo:UBPROP_0000001 "The eminence in the embryo which develops into the clitoris or penis. [TFD][VHOG]", "embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until ~E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP]" ; obo:UBPROP_0000003 "In mammalian embryos, male and female external genitalia develop from the genital tubercle.[well established][VHOG]" ; obo:UBPROP_0000008 "All amniotes studied to date initiate external genital development with the formation of paired genital swellings. In mammals, archosaurs, and turtles, these swellings merge to form a single genital tubercle, the precursor of the penis and clitoris[PMID:24960313]", "GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP:0011771]", "todo - add taxon constraints" ; obo:UBPROP_0000012 "we assume the EMAPA class is the undifferentiated form based on TS timings" ; oboInOwl:hasDbXref "EHDAA2:0000705", "EHDAA:5925", "EMAPA:17382", "FMA:302888", "SCTID:308798005", "VHOG:0000583", "Wikipedia:Genital_tubercle" ; oboInOwl:hasExactSynonym "undifferentiated genital tubercle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "genital tubercle", "phallic tubercle", "tuberculum genitale", "tuberculum phallicum" ; oboInOwl:id "UBERON:0005876" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "undifferentiated genital tubercle" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004874 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0011757 ], _:genid142382 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d6/Gray1119.png"^^xsd:anyURI . obo:UBERON_0005879 obo:IAO_0000115 "An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches." ; obo:IAO_0000116 "Note we use overlaps as the relationship to the arches" ; obo:UBPROP_0000012 "EMAPA distinguishes between the groove ectoderm and epithelium, with the latter arising after the former" ; oboInOwl:hasBroadSynonym "pharyngeal groove" ; oboInOwl:hasDbXref "AAO:0010623", "EMAPA:32750", "FMA:295672", "NCIT:C34250", "UMLS:C1280559", "Wikipedia:Pharyngeal_groove" ; oboInOwl:hasExactSynonym "pharyngeal groove ectoderm" ; oboInOwl:hasNarrowSynonym "gill cleft" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Kiemenspalten", "branchial cleft", "branchial groove", "pharyngeal ectodermal cleft", "pharyngeal slit", "sulcus pharyngei" ; oboInOwl:id "UBERON:0005879" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pharyngeal cleft" ; rdfs:subClassOf obo:UBERON_0006846, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016545 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002539 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004117 ], _:genid142396 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Kiemenbogen.jpg"^^xsd:anyURI . obo:UBERON_0005881 obo:IAO_0000115 "A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit or predigit", "limb outgrowth" ; oboInOwl:id "UBERON:0005881" ; a owl:Class ; rdfs:comment "encompasses digits and prepollex. requires review" ; rdfs:label "autopodial extension" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] . obo:UBERON_0005884 obo:IAO_0000115 "A subdivision of skeleton that supports pharyngeal arch 2." ; obo:UBPROP_0000012 "it's not clear where AAO:'hyobranchial skeleton' belongs" ; oboInOwl:hasDbXref "AAO:0000665", "AAO:0010370", "TAO:0001276", "XAO:0003177", "ZFA:0001276" ; oboInOwl:hasExactSynonym "hyoid arch skeleton", "pharyngeal arch 2 skeleton" ; oboInOwl:hasNarrowSynonym "hyoid bars" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hyoid arch", "visceral arch 2" ; oboInOwl:id "UBERON:0005884" ; a owl:Class ; rdfs:label "hyoid arch skeleton" ; rdfs:subClassOf obo:UBERON_0010912, _:genid142412, _:genid142414 . obo:UBERON_0005891 obo:IAO_0000115 "The epithelial lining of the surface of the coelom." ; obo:UBPROP_0000012 "EHDAA2:0004049 used to be called 'coelomic epithelium' but is now 'gonadal ridge mesothelium'" ; oboInOwl:hasDbXref "Wikipedia:Coelomic_epithelium", "XAO:0000329" ; oboInOwl:hasExactSynonym "celomic epithelium", "germinal epithelium of Waldeyer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005891" ; a owl:Class ; rdfs:label "coelomic epithelium" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011997 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 ], _:genid142425, _:genid142427 . obo:UBERON_0005893 obo:IAO_0000115 "A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx." ; oboInOwl:hasDbXref "EMAPA:37304", "MA:0000670", "MESH:D007867" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005893" ; oboInOwl:inSubset core:grouping_class, core:human_reference_atlas ; a owl:Class ; rdfs:label "leg bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) ] . obo:UBERON_0005897 obo:IAO_0000115 "A bone that is part of the manus skeleton. Note that this includes the carpal bones." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:35391", "MA:0000619", "SCTID:426741001" ; oboInOwl:hasExactSynonym "bone of hand", "bone of hand skeleton", "bone of manus", "bone of pectoral limb autopod", "bone of pectoral limb autopodium", "forelimb autopod bone", "forelimb autopodium bone", "hand bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005897" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "manus bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0005899 obo:IAO_0000115 "A bone that is part of the pes skeleton." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:35354", "GAID:192", "MA:0000643", "MESH:D005529", "NCIT:C13068", "SCTID:361371005", "UMLS:C0016505" ; oboInOwl:hasExactSynonym "bone of foor proper or tarsal skeleton", "bone of foot", "bone of pedal skeleton", "bone of pes", "foot bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005899" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pes bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001445 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0005902 obo:IAO_0000115 "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles." ; obo:IAO_0000116 "TODO - check" ; obo:UBPROP_0000001 "An anatomical cluster that is located in the posterior region of the neurocranium and forms the margin of the foramen margin and occipital condyles.[AAO]", "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occiptal condyle.[TAO]" ; oboInOwl:hasDbXref "AAO:0010199", "BTO:0004675", "FMA:49187", "SCTID:362618001", "TAO:0001414", "XAO:0003173", "ZFA:0001414", "neuronames:2431" ; oboInOwl:hasExactSynonym "basicranial region", "occipital part of head", "occipital region of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "back of head" ; oboInOwl:id "UBERON:0005902" ; a owl:Class ; rdfs:label "occipital region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] . obo:UBERON_0005903 obo:IAO_0000115 "Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP]." ; oboInOwl:hasDbXref "EMAPA:29282", "FMA:19473", "SCTID:279675008", "Wikipedia:Excretory_duct_of_seminal_gland" ; oboInOwl:hasExactSynonym "ductus excretorius (vesicula seminalis)", "ductus excretorius glandulae vesiculosae", "excretory duct of seminal gland", "seminal vesicle duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus excretorius glandulae vesiculosae" ; oboInOwl:id "UBERON:0005903" ; a owl:Class ; rdfs:label "duct of seminal vesicle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0010143 ], [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0000999 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1160.png"^^xsd:anyURI . obo:UBERON_0005904 obo:IAO_0000115 "Any of the ducts that are part of a male reproductive system." ; obo:IAO_0000232 "this class groups the individual ducts in a variety of species" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005904" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "duct of male reproductive system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0005906 obo:IAO_0000115 "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]." ; oboInOwl:hasDbXref "EMAPA:16060", "FMA:9689", "MA:0000005", "SCTID:362890006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005906" ; a owl:Class ; rdfs:comment "See notes for serous membrane" ; rdfs:label "serous sac" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000042 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002553 ] . obo:UBERON_0005908 obo:IAO_0000115 "A serous sac which is the aggregate of the conjunctiva plus the conjunctival space." ; oboInOwl:hasDbXref "EMAPA:18233", "FMA:20291", "SCTID:362531001" ; oboInOwl:hasExactSynonym "conjunctiva serous sac" ; oboInOwl:hasNarrowSynonym "subbrillar sac" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005908" ; a owl:Class ; rdfs:label "conjunctival sac" ; rdfs:subClassOf obo:UBERON_0005906, _:genid142482, _:genid142484, _:genid142486 . obo:UBERON_0005911 obo:IAO_0000115 "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]." ; oboInOwl:hasDbXref "FMA:69065" ; oboInOwl:hasExactSynonym "endoderm-derived epithelium", "endoepithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005911" ; a owl:Class ; rdfs:label "endo-epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0005913 oboInOwl:hasDbXref "FMA:10483" ; oboInOwl:hasExactSynonym "bone organ zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005913" ; a owl:Class ; rdfs:label "zone of bone organ" ; rdfs:subClassOf obo:UBERON_0034944, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] . obo:UBERON_0005928 obo:IAO_0000115 "A naris that provides one of the small external openings of the head that give passage to air for breathing." ; obo:UBPROP_0000001 "Hole on the nasal capsule that connects the nasal cavity with the exterior.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass nasal opening (AAO:0000316)[AAO]" ; obo:UBPROP_0000003 "In a tetrapod, the nasal sac has an external naris (homologous with the anterior naris of the fish) (...).[well established][VHOG]" ; obo:UBPROP_0000008 "Fish have two pairs of external nostrils." ; oboInOwl:hasBroadSynonym "naris" ; oboInOwl:hasDbXref "AAO:0000024", "AAO:0000983", "AAO:0010358", "EHDAA2:0001275", "EHDAA:9085", "EMAPA:17848", "FMA:59645", "MA:0001320", "NCIT:C33178", "SCTID:276165005", "TAO:0000550", "UMLS:C0595944", "VHOG:0000544", "Wikipedia:Nostril", "XAO:0003033", "ZFA:0000550" ; oboInOwl:hasExactSynonym "external nares", "nostril" ; oboInOwl:hasNarrowSynonym "blowhole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior nares", "anterior naris" ; oboInOwl:id "UBERON:0005928" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "external naris" ; rdfs:subClassOf obo:UBERON_0003102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007585 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000004 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001707 ] _:genid141059 ) ] . obo:UBERON_0005944 obo:IAO_0000115 "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." ; obo:UBPROP_0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" ; oboInOwl:hasDbXref "AAO:0000963", "EMAPA:17214", "EMAPA:18043", "MA:0000308", "NCIT:C32172", "SCTID:361725000", "UMLS:C0222645", "VSAO:0000056", "Wikipedia:Axial_skeleton", "XAO:0004011" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeleton axiale" ; oboInOwl:id "UBERON:0005944" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "axial skeleton plus cranial skeleton" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004288 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011137 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001434 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg"^^xsd:anyURI . obo:UBERON_0005945 oboInOwl:hasBroadSynonym "trabecula", "trabecular cartilage" ; oboInOwl:hasDbXref "EFO:0003677", "TAO:0001321", "ZFA:0001321" ; oboInOwl:hasExactSynonym "neurocranial trabeculae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005945" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "neurocranial trabecula" ; rdfs:subClassOf obo:UBERON_0000440, obo:UBERON_0003932, _:genid142529, _:genid142531 . obo:UBERON_0005946 obo:IAO_0000115 "An outflow tract that is part of a cardiac atrium." ; oboInOwl:hasDbXref "FMA:14141" ; oboInOwl:hasExactSynonym "outflow part of atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005946" ; a owl:Class ; rdfs:label "outflow tract of atrium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid141091 ] . obo:UBERON_0005953 obo:IAO_0000115 "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk." ; oboInOwl:hasBroadSynonym "infundibulum" ; oboInOwl:hasDbXref "EMAPA:37926", "FMA:7216", "NCIT:C61368", "SCTID:244379003", "UMLS:C1881209" ; oboInOwl:hasExactSynonym "RVOT", "conus arteriosus (infundibulum)", "infundibulum of right ventricle", "outflow tract of right ventricle", "pulmonary conus", "right ventricle pulmonary outflow tract", "right ventricular outflow tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arterial cone", "conus arteriosus", "pulmonary cone", "pulmonary conus" ; oboInOwl:id "UBERON:0005953" ; a owl:Class ; rdfs:label "outflow part of right ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002333 ], _:genid142548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005337 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0005956 obo:IAO_0000115 "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." ; oboInOwl:hasDbXref "EMAPA:37925", "FMA:9473", "SCTID:264070001", "Wikipedia:Aortic_vestibule" ; oboInOwl:hasExactSynonym "LVOT", "Sibson vestibule", "aortic vestibule", "heart left ventricle outflow tract", "left ventricular outflow", "left ventricular outflow tract", "outflow tract of left ventricle", "vestibulum aortae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005956" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "outflow part of left ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005337 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0005965 obo:IAO_0000115 "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]." ; oboInOwl:hasDbXref "FMA:9550" ; oboInOwl:hasExactSynonym "main part of right atrium", "outflow tract of right atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005965" ; a owl:Class ; rdfs:label "outflow part of right atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005946 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ] ) ] . obo:UBERON_0005966 obo:IAO_0000115 "An outflow tract of atrium that is part of a left atrium." ; oboInOwl:hasDbXref "FMA:9551" ; oboInOwl:hasExactSynonym "main part of left atrium", "outflow tract of left atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005966" ; a owl:Class ; rdfs:label "outflow part of left atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005946 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002079 ] ) ] . obo:UBERON_0005969 obo:IAO_0000115 "A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP]." ; obo:IAO_0000116 "TODO check syns - ligaments" ; oboInOwl:hasAlternativeId "UBERON:0004028" ; oboInOwl:hasDbXref "BTO:0001605", "CALOHA:TS-1058", "EFO:0003077", "EV:0100352", "FMA:77660", "GAID:897", "MA:0003086", "MESH:D014129", "NCIT:C12803", "SCTID:280694002", "UMLS:C0040573", "Wikipedia:Trabecular_meshwork" ; oboInOwl:hasExactSynonym "eye trabecular meshwork", "reticulum trabeculare", "trabecular meshwork of the eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Hueck's ligament", "cribiform ligament", "iridis", "ligamentum peactin-tum iridis", "ligamentum pectinatum", "ligamentum pectinatum anguli iridocornealis", "ligamentum pectinatum iridis", "pectinate ligament", "pectinate ligament of iris", "reticulum trabeculare sclerae", "scleral trabeculae", "scleral trabecular", "scleral trabecule", "scribiform ligament", "trabecular mesh", "trabecular meshwork" ; oboInOwl:id "UBERON:0005969" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "eye trabecular meshwork" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003956 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002367 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0006206 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001766 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray870.png"^^xsd:anyURI . obo:UBERON_0005970 obo:IAO_0000115 "Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain." ; obo:UBPROP_0000001 "any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain[MP]" ; oboInOwl:hasDbXref "EMAPA:37446" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005970" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brain commissure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0000955 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0005971 obo:IAO_0000115 "A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong]." ; oboInOwl:hasDbXref "EMAPA:16076" ; oboInOwl:hasExactSynonym "amnionic fold" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005971" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "amniotic fold" ; rdfs:subClassOf obo:UBERON_0000478, _:genid142627 . obo:UBERON_0005979 obo:IAO_0000115 "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium." ; oboInOwl:hasDbXref "EMAPA:37837", "FMA:9236", "SCTID:277693004", "Wikipedia:Crista_terminalis" ; oboInOwl:hasExactSynonym "crista terminalis atrii dextri", "crista terminalis cordis", "crista terminalis of right atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005979" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "crista terminalis" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002078 ] . obo:UBERON_0005983 obo:IAO_0000115 "The laminar structure of the heart." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005983" ; oboInOwl:inSubset core:non_informative, core:pheno_slim ; a owl:Class ; rdfs:label "heart layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0005985 obo:IAO_0000115 "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation." ; obo:IAO_0000116 "TODO - change relation from part_of" ; oboInOwl:hasDbXref "MESH:D003331", "Wikipedia:Coronary_circulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005985" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "coronary vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000948 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000055 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0005988 obo:IAO_0000115 "The supporting bundles of muscular fibers lining the walls of the atrial myocardium." ; oboInOwl:hasDbXref "EMAPA:37432", "ZFA:0005810" ; oboInOwl:hasExactSynonym "atrial trabecula", "atrium myocardial trabeculae", "trabecula of atrium", "trabecular layer of atrium", "trabecular layer of the atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005988" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "atrium myocardial trabecula" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002302 ], _:genid142654 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002302 ] ) ] . obo:UBERON_0005989 obo:IAO_0000115 "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve." ; oboInOwl:hasDbXref "EMAPA:37431", "FMA:7136", "SCTID:280151006", "Wikipedia:Atrioventricular_septum" ; oboInOwl:hasExactSynonym "membranous atrioventricular septum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005989" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "atrioventricular septum" ; rdfs:subClassOf _:genid142667 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002099 _:genid141214 _:genid141216 ) ] . obo:UBERON_0005990 obo:IAO_0000115 "The three fibrous triangular components and associated flap of the aortic valve." ; oboInOwl:hasDbXref "FMA:7251", "SCTID:362026005" ; oboInOwl:hasExactSynonym "aortic semilunar valvule", "aortic valvular cusp", "cusp of aortic valve", "semilunar valvule of aortic valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005990" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aortic valve cusp" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002137 ] ; owl:equivalentClass _:genid141222 . obo:UBERON_0005991 obo:IAO_0000115 "The fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps." ; oboInOwl:hasDbXref "EMAPA:37418", "FMA:9502" ; oboInOwl:hasExactSynonym "anulus of aortic valve", "aortic anulus", "aortic valvar anulus", "fibrous ring of aortic valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005991" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aortic valve anulus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002137 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid141233 ] . obo:UBERON_0005992 obo:IAO_0000115 "The three fibrous triangular components and associated flap of the pulmonary valve." ; oboInOwl:hasDbXref "FMA:7248" ; oboInOwl:hasExactSynonym "cusp of pulmonary valve", "pulmonary semilunar valvule", "pulmonary valvular cusp", "semilunar cusp of pulmonary valve", "semilunar valvule of pulmonary valve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005992" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary valve cusp" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002146 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002146 ] ) ] . obo:UBERON_0005993 obo:IAO_0000115 "The fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps." ; oboInOwl:hasDbXref "EMAPA:37420", "FMA:9503" ; oboInOwl:hasExactSynonym "anulus of pulmonary valve", "fibrous ring of pulmonary valve", "pulmonary anulus", "pulmonary valvar anulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005993" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary valve anulus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002146 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002146 ] ) ] . obo:UBERON_0005994 obo:IAO_0000115 "The tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria." ; oboInOwl:hasDbXref "EMAPA:36322", "FMA:12225", "GAID:564", "MESH:D002815", "NCIT:C32307", "SCTID:279330004", "UMLS:C0008484", "Wikipedia:Chordae_tendineae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chordae tendinea", "chordae tendineae cordis" ; oboInOwl:id "UBERON:0005994" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chorda tendineae" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002133 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002133 ], _:genid142716 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png"^^xsd:anyURI . obo:UBERON_0005995 obo:IAO_0000115 "The fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps." ; oboInOwl:hasDbXref "EMAPA:37419", "FMA:9498", "Wikipedia:Mitral_annulus" ; oboInOwl:hasExactSynonym "anulus of mitral valve", "fibrous ring of mitral valve", "mitral annulus", "mitral anulus", "mitral valvar anulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005995" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mitral valve anulus" ; rdfs:subClassOf _:genid141278 ; owl:equivalentClass _:genid141272 . obo:UBERON_0005996 obo:IAO_0000115 "The two fibrous components and associated flaps of the mitral valve." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005996" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mitral valve cusp" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002135 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002135 ] ) ] . obo:UBERON_0005997 obo:IAO_0000115 "The fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp)." ; oboInOwl:hasDbXref "EMAPA:37421", "FMA:9500" ; oboInOwl:hasExactSynonym "anulus of tricuspid valve", "fibrous ring of tricuspid valve", "tricuspid anulus", "tricuspid valvar anulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005997" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tricuspid valve anulus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002134 ] ) ] . obo:UBERON_0005998 obo:IAO_0000115 "The three fibrous triangular components and associated flaps of the tricuspid valve." ; obo:IAO_0000116 "check whether we need to separate cusp/leaflet/valve" ; oboInOwl:hasDbXref "FMA:7240", "SCTID:261417002" ; oboInOwl:hasExactSynonym "cuspis septalis (valva tricuspidalis)", "cuspis septalis valvae atrioventricularis dextrae", "septal cusp of right atrioventricular valve", "septal cusp of tricuspid valve", "septal leaflet of right-sided tricuspid valve", "septal leaflet of tricuspid valve", "septal tricuspid leaflet" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0005998" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tricuspid valve cusp" ; rdfs:subClassOf obo:UBERON_0005484, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002134 ] ) ] . obo:UBERON_0006002 obo:IAO_0000115 "The paired arteries that carry blood to the yolk sac from the dorsal aorta." ; oboInOwl:hasDbXref "EHDAA2:0002208", "EMAPA:16207", "Wikipedia:Vitelline_arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006002" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664]" ; rdfs:label "vitelline artery" ; rdfs:subClassOf _:genid142772 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png"^^xsd:anyURI . obo:UBERON_0006003 obo:IAO_0000115 "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." ; obo:IAO_0000116 "add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis." ; obo:UBPROP_0000001 "the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678]" ; oboInOwl:hasDbXref "EMAPA:37883", "Wikipedia:Skin_appendage" ; oboInOwl:hasNarrowSynonym "body hair or bristle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adnexae cutis", "skin adnexa", "skin adnexal structure", "skin appendage" ; oboInOwl:id "UBERON:0006003" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "integumentary adnexa" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] . obo:UBERON_0006008 obo:IAO_0000115 "A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices." ; obo:IAO_0000116 "TODO - compare with ZFA atrioventricular ring, part of the conduction system" ; oboInOwl:hasDbXref "BTO:0003628", "EMAPA:37422", "FMA:9497", "Wikipedia:Fibrous_rings_of_heart" ; oboInOwl:hasExactSynonym "anulus fibrosus of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Lower's ring", "annulus fibrosus cordis", "anulus fibrosus cordis", "aortic annulus", "atrioventricular ring", "coronary tendon", "fibrous ring of heart" ; oboInOwl:id "UBERON:0006008" ; a owl:Class ; rdfs:label "fibrous ring of heart" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006444 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0006009 obo:IAO_0000115 "The part of the heart valves that serves to seal the heart valves when closed. There are three cusps for each valve except for the mitral valve, which has only two (hence its alternate name, 'bicuspid valve'). 'Nodules' are located at the tip of the valve, to form a tighter seal[WP]." ; oboInOwl:hasDbXref "FMA:7232", "NCIT:C33849", "SCTID:30822008", "UMLS:C0225923", "Wikipedia:Cusps_of_heart_valves" ; oboInOwl:hasExactSynonym "cardiac valve cusp", "cardiac valvular cusp", "cardiac valvule", "cardial valve cusp", "semilunar valvule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006009" ; a owl:Class ; rdfs:label "cusp of cardiac valve" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png"^^xsd:anyURI . obo:UBERON_0006010 obo:IAO_0000115 "A small transparent canal running through the vitreous body from the optical nerve disc to the lens. It is formed by an invagination of the hyaloid, a membrane which encloses the vitreous body[WP]." ; oboInOwl:hasDbXref "FMA:58837", "SCTID:362506002", "Wikipedia:Hyaloid_canal" ; oboInOwl:hasExactSynonym "Cloquet's canal", "Stilling's canal", "canal of Cloquet", "canalis hyaloideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006010" ; a owl:Class ; rdfs:label "hyaloid canal" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001799 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001798 ], _:genid142806 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png"^^xsd:anyURI . obo:UBERON_0006048 obo:IAO_0000115 "A digit that is part of a digit 1 plus metapodial segment." ; obo:UBPROP_0000104 "1"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:37285", "MA:0003023" ; oboInOwl:hasExactSynonym "autopod digit 1", "digit I", "limb digit 1" ; oboInOwl:hasNarrowSynonym "dewclaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006048" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0002470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006048 ] ) ] . obo:UBERON_0006049 obo:IAO_0000115 "A digit that is part of a digit 2 plus metapodial segment." ; obo:UBPROP_0000104 "2"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:37286" ; oboInOwl:hasExactSynonym "autopod digit 2", "digit II", "limb digit 2", "second digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006049" ; a owl:Class ; rdfs:label "digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006049 ] ) ] . obo:UBERON_0006050 obo:IAO_0000115 "A digit that is part of a digit 3 plus metapodial segment." ; obo:UBPROP_0000104 "3"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:37287" ; oboInOwl:hasExactSynonym "autopod digit 3", "digit III", "limb digit 3", "third digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006050" ; a owl:Class ; rdfs:label "digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006050 ] ) ] . obo:UBERON_0006051 obo:IAO_0000115 "A digit that is part of a digit 4 plus metapodial segment." ; obo:UBPROP_0000104 "4"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:37288" ; oboInOwl:hasExactSynonym "autopod digit 4", "digit IV", "fourth digit", "limb digit 4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006051" ; a owl:Class ; rdfs:label "digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006051 ] ) ] . obo:UBERON_0006052 obo:IAO_0000115 "A digit that is part of a digit 5 plus metapodial segment." ; obo:UBPROP_0000104 "5"^^xsd:nonNegativeInteger ; oboInOwl:hasDbXref "EMAPA:17441", "EMAPA:37289" ; oboInOwl:hasExactSynonym "autopod digit 5", "digit V", "fifth digit", "limb digit 5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digiti minimi" ; oboInOwl:id "UBERON:0006052" ; a owl:Class ; rdfs:label "digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid141392 ] . obo:UBERON_0006056 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006056" ; a owl:Class ; rdfs:label "posterior surface of head" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0006058 obo:IAO_0000115 "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006058" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "multi-limb segment region" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/514"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010758, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002529 ] . obo:UBERON_0006059 obo:IAO_0000115 "The falx cerebri, also known as the cerebral falx, so named from its sickle-like form, is a strong, arched fold of dura mater which descends vertically in the longitudinal fissure between the cerebral hemispheres. It is narrow in front, where it is attached to the crista galli of the ethmoid; and broad behind, where it is connected with the upper surface of the tentorium cerebelli. Its upper margin is convex, and attached to the inner surface of the skull in the middle line, as far back as the internal occipital protuberance; it contains the superior sagittal sinus. Its lower margin is free and concave, and contains the inferior sagittal sinus. The falx cerebri is known to calcify with age." ; oboInOwl:hasDbXref "EMAPA:18551", "FMA:83967", "NCIT:C12890", "SCTID:279275004", "UMLS:C0228120", "Wikipedia:Falx_cerebri", "neuronames:1237" ; oboInOwl:hasExactSynonym "cerebral falx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006059" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "falx cerebri" ; rdfs:subClassOf obo:UBERON_0000064, _:genid141405, _:genid142859 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/ff/Falxcerebri.jpg"^^xsd:anyURI . obo:UBERON_0006061 obo:IAO_0000115 "A process projection from a part of the vertebra such as centrum or arches. Examples: transverse process, diapophyses, parapophyses, and zygapophyses (both the cranial zygapophyses and the caudal zygapophyses)." ; oboInOwl:hasDbXref "AAO:0000739", "FMA:24530", "NCIT:C116112", "Wikipedia:Vertebral_column#Structure_of_individual_vertebrae" ; oboInOwl:hasExactSynonym "vertebra process", "vertebral process" ; oboInOwl:hasNarrowSynonym "spinous process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006061" ; a owl:Class ; rdfs:label "process of vertebra" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002412 ] . obo:UBERON_0006062 obo:IAO_0000115 "Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region[AAO]. The articular processes or zygapophyses of a vertebra, in human anatomy contain two superior and two inferior, spring from the junctions of the pedicles and laminae. These stick out of an end of a vertebra to lock with a zygapophysis on the next vertebra, to make the backbone more stable. The superior processes project upward from a lower vertebra, and their articular surfaces are directed more or less backward. The inferior processes project downward from a higher vertebra, and their articular surfaces are directed more or less forward and outward. The articular surfaces are coated with hyaline cartilage." ; obo:IAO_0000116 "TODO - class as endochondral bone, check species" ; obo:UBPROP_0000001 "Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region.[AAO]" ; oboInOwl:hasBroadSynonym "articular process" ; oboInOwl:hasDbXref "AAO:0000710", "FMA:11952", "SCTID:317570004", "TAO:0001549", "Wikipedia:Articular_processes", "ZFA:0001603" ; oboInOwl:hasExactSynonym "articular process of vertebra", "processus articularis (zygapophysis)", "zygapophysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intercalarium articulating process", "p. articularis vertebrae", "processus articularis vertebrae" ; oboInOwl:id "UBERON:0006062" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "zygapophysis" ; rdfs:subClassOf obo:UBERON_0006061, _:genid141414 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Processusarticularissuperiorvertebrae.png"^^xsd:anyURI . obo:UBERON_0006063 obo:IAO_0000115 "One of the cartilaginous structures surrounding the embryonic spinal cord, formed by the dorsal growth of the dorsolateral arcualia; it is the primordium of the vertebral arch." ; oboInOwl:hasDbXref "BTO:0001763" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural arch primordium" ; oboInOwl:id "UBERON:0006063" ; a owl:Class ; rdfs:label "cartilaginous neural arch" ; rdfs:subClassOf obo:UBERON_0010358, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002418 ] . obo:UBERON_0006067 obo:IAO_0000115 "Any collection of muscles that is part of a hindlimb zeugopod." ; oboInOwl:hasDbXref "FMA:50211" ; oboInOwl:hasExactSynonym "leg musculature", "muscle group of leg", "set of muscles of leg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006067" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "musculature of hindlimb zeugopod" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) ] . obo:UBERON_0006068 obo:IAO_0000115 "A bone that is part of a post-anal tail." ; obo:UBPROP_0000012 "MA has distinct classes for 'tail bone', 'caudal vertebra' and 'coccygeal vertebra' but these may all be equivalent. This class may be obsoleted in future." ; oboInOwl:hasDbXref "EMAPA:18042", "MA:0000696" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tail bone", "tail vertebra" ; oboInOwl:id "UBERON:0006068" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone of tail" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0006071 obo:IAO_0000115 "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this." ; obo:UBPROP_0000008 "This region is reduced in humans and corresponds to the coccyx" ; obo:UBPROP_0000012 "We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud" ; oboInOwl:hasDbXref "XAO:0000087" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "post-anal caudal region", "post-anal tail region", "postsacral region", "tail region" ; oboInOwl:id "UBERON:0006071" ; a owl:Class ; rdfs:label "caudal region" ; rdfs:subClassOf obo:UBERON_0011676, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000154 ], _:genid141444, [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0006076 ] . obo:UBERON_0006072 obo:IAO_0000115 "That portion of the spine comprising the cervical vertebrae. The neck area of the spine." ; obo:UBPROP_0000001 "Anterior region of the vertebral column consisting of one to 19 or 20 vertebrae.[AAO]" ; oboInOwl:hasDbXref "AAO:0000092", "BTO:0004148", "EHDAA2:0000238", "EHDAA:5051", "EMAPA:17215", "FMA:24138", "MA:0003154", "NCIT:C69313", "SCTID:260488005", "UMLS:C0728985" ; oboInOwl:hasExactSynonym "axial skeleton cervical region", "cervical skeleton", "cervical spinal column", "cervical spine", "cervical vertebrae series", "cervical vertebral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skeletal system of neck" ; oboInOwl:id "UBERON:0006072" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cervical region of vertebral column" ; rdfs:subClassOf _:genid141456, _:genid142911 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0005434 ] ) ] . obo:UBERON_0006073 obo:IAO_0000115 "That part of the spine comprising the thoracic vertebrae." ; obo:UBPROP_0000001 "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" ; oboInOwl:hasDbXref "AAO:0000612", "BTO:0004150", "EHDAA:5063", "EMAPA:17396", "FMA:9140", "MA:0003155", "NCIT:C69315", "SCTID:243931006", "UMLS:C0581269" ; oboInOwl:hasExactSynonym "axial skeleton thoracic region", "columna vertebralis thoracicus", "thoracic spine", "thoracic vertebrae series", "thoracic vertebral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006073" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "thoracic region of vertebral column" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014477 ], _:genid142926 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0006074 obo:IAO_0000115 "Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae." ; obo:UBPROP_0000007 "lumbar" ; oboInOwl:hasDbXref "BTO:0004147", "EHDAA2:0001037", "EHDAA:5055", "EMAPA:17393", "FMA:16203", "GAID:31", "MA:0003156", "NCIT:C69314", "SCTID:243932004" ; oboInOwl:hasExactSynonym "axial skeleton lumbar region", "lumbar skeleton", "lumbar spine", "lumbar vertebrae series", "lumbar vertebral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006074" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lumbar region of vertebral column" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0005462 ] ) ] . obo:UBERON_0006075 obo:IAO_0000115 "Subdivision of vertebral column that corresponds to the sacral subdivision of the body, containing the sacral vertebrae or sacrum." ; obo:UBPROP_0000001 "Region of the vertebral column represented by one or two vertebrae.[AAO]" ; obo:UBPROP_0000008 "In adult humans, the sacral skeleton is fused and called the sacrum" ; oboInOwl:hasDbXref "AAO:0000724", "EHDAA2:0001772", "EHDAA:5059", "EMAPA:17676", "GAID:32", "MA:0003157", "NCIT:C33508", "Wikipedia:Sacrum" ; oboInOwl:hasExactSynonym "axial skeleton sacral region", "sacral skeleton", "sacral vertebrae series" ; oboInOwl:hasNarrowSynonym "sacrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006075" ; a owl:Class ; rdfs:label "sacral region of vertebral column" ; rdfs:subClassOf _:genid141495, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 _:genid141493 ) ] . obo:UBERON_0006076 obo:IAO_0000115 "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae." ; obo:UBPROP_0000001 "Region of the vertebral column posterior to the caudal-sacral region, that may consists of two or three to more than 100 vertebrae. These vertebrae exhibit a gradual reduction in the sizes of their transverse processes and zygapophyses, but these structures are never entirely absent. All caudal vertebrae bear haemal arches.[AAO]" ; obo:UBPROP_0000012 "in AAO, this is posterior to the caudal-sacral region" ; oboInOwl:hasDbXref "AAO:0000082", "EMAPA:18043", "MA:0003158" ; oboInOwl:hasExactSynonym "axial skeleton tail region", "caudal skeleton", "caudal vertebrae series" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caudal region", "postsacral region", "tail region" ; oboInOwl:id "UBERON:0006076" ; a owl:Class ; rdfs:label "caudal region of vertebral column" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006071 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0006071 ] ) ] . obo:UBERON_0006077 obo:IAO_0000115 "A collection of all skeletal elements in some subdivision of the vertebral column." ; oboInOwl:hasDbXref "FMA:16201" ; oboInOwl:hasExactSynonym "subdivision of vertebral skeleton", "vertebrae series", "vertebral column subdivision", "vertebral series" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vertebral region", "vertebral subdivision" ; oboInOwl:id "UBERON:0006077" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of vertebral column" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ], _:genid142977 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid141517 ] . obo:UBERON_0006098 obo:IAO_0000115 "The deep nuclei of telencephalic origin found in the basal region of the forebrain." ; oboInOwl:hasDbXref "BAMS:BG", "BAMS:BNC", "BIRNLEX:1629", "EV:0100182", "UMLS:C0004781", "neuronames:224" ; oboInOwl:hasExactSynonym "basal nuclei", "basal nuclei of the forebrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal ganglia", "basal ganglia (anatomic)", "corpus striatum (Savel'ev)", "ganglia basales" ; oboInOwl:id "UBERON:0006098" ; a owl:Class ; rdfs:label "basal nuclear complex" ; rdfs:subClassOf obo:UBERON_0007245, _:genid141525 . obo:UBERON_0006127 obo:IAO_0000115 "A funiculus of neuraxis that is part of a spinal cord." ; oboInOwl:hasDbXref "FMA:77460", "neuronames:2760" ; oboInOwl:hasExactSynonym "spinal cord funiculus", "white column of spinal cord" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006127" ; a owl:Class ; rdfs:label "funiculus of spinal cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002318 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006133 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0006133 obo:IAO_0000115 "The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans." ; oboInOwl:hasDbXref "FMA:76738", "Wikipedia:Funiculus_(neurology)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006133" ; a owl:Class ; rdfs:label "funiculus of neuraxis" ; rdfs:subClassOf obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 ] . obo:UBERON_0006134 obo:IAO_0000115 "A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system." ; obo:UBPROP_0000007 "neurofibrous" ; oboInOwl:hasDbXref "BAMS:nfi", "FMA:5914", "MESH:D009412", "SCTID:88545005", "Wikipedia:Nervous_system_fiber" ; oboInOwl:hasExactSynonym "nerve fibre", "neurofibra", "neurofibrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nerve fibers", "neurofibra" ; oboInOwl:id "UBERON:0006134" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "nerve fiber" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001019 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0030424 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:CL_0000540 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006135 obo:UBERON_0006136 ) ] . obo:UBERON_0006135 obo:IAO_0000115 "Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH)." ; obo:IAO_0000116 "consider adding link to UBERON:0002316 ! white matter of neuraxis" ; obo:UBPROP_0000008 "http://www1.pbrc.hawaii.edu/~danh/MyelinEvolution/evolution.html, http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6134604, Wikipedia:Myelin#Invertebrate_myelin" ; oboInOwl:hasDbXref "FMA:5915", "GAID:745", "MESH:D009413", "NCIT:C12627", "SCTID:362296008", "UMLS:C0027750" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006135" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "myelinated nerve fiber" ; owl:disjointWith obo:UBERON_0006136 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0043209 ] ) ] . obo:UBERON_0006136 oboInOwl:hasDbXref "FMA:5916", "GAID:767", "MESH:D036421", "NCIT:C33835", "SCTID:46920005", "UMLS:C0501409" ; oboInOwl:hasExactSynonym "non-myelinated nerve fiber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006136" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "unmyelinated nerve fiber" ; rdfs:subClassOf obo:UBERON_0006134 . obo:UBERON_0006170 obo:IAO_0000115 "The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006170" ; a owl:Class ; rdfs:label "mesonephric capsule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0006183 obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006183" ; a owl:Class ; rdfs:label "mesonephric glomerular capillary" ; rdfs:subClassOf _:genid143031, _:genid143033 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004212 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) ] . obo:UBERON_0006203 oboInOwl:hasBroadSynonym "concha" ; oboInOwl:hasDbXref "FMA:61006", "NCIT:C32362", "UMLS:C0229316" ; oboInOwl:hasExactSynonym "concha auriculae", "concha of auricle", "concha of pinna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006203" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "conchal part of pinna" ; rdfs:subClassOf obo:UBERON_0000064, _:genid141577, _:genid143037 . obo:UBERON_0006204 obo:IAO_0000115 "A band running from the pubic tubercle to the anterior superior iliac spine. Its anatomy is very important for operating on hernia patients. It forms the base of the inguinal canal through which an indirect inguinal hernia may develop. The inguinal ligament runs from the anterior superior iliac spine of the ilium to the pubic tubercle of the pubic bone. It is formed by the external abdominal oblique aponeurosis and is continuous with the fascia lata of the thigh." ; oboInOwl:hasDbXref "FMA:19855", "SCTID:361900000", "Wikipedia:Inguinal_ligament" ; oboInOwl:hasExactSynonym "Poupart's ligament", "Vesalius' ligament", "fallopian ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006204" ; a owl:Class ; rdfs:label "inguinal ligament" ; rdfs:subClassOf obo:UBERON_0000211, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005442 ] . obo:UBERON_0006206 obo:IAO_0000115 "Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP]." ; oboInOwl:hasDbXref "FMA:58577", "SCTID:244498000" ; oboInOwl:hasExactSynonym "anterior chamber angle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006206" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "iridocorneal angle" ; rdfs:subClassOf obo:UBERON_0000015, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003956 ] . obo:UBERON_0006207 obo:IAO_0000115 "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions." ; oboInOwl:hasAlternativeId "UBERON:0005999" ; oboInOwl:hasDbXref "CALOHA:TS-2409", "EHDAA2:0000136", "EHDAA:2592", "EMAPA:16827", "VHOG:0000502", "Wikipedia:Aorticopulmonary_septum" ; oboInOwl:hasExactSynonym "aortico-pulmonary septum", "aorticopulmonary septum", "septum aorticopulmonale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aortic septum", "spiral septum" ; oboInOwl:id "UBERON:0006207" ; oboInOwl:inSubset core:emapa_ehdaa2, core:pheno_slim ; a owl:Class ; rdfs:label "aortico-pulmonary spiral septum" ; rdfs:subClassOf _:genid143058, _:genid143060 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002099 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002333 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005805 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png"^^xsd:anyURI . obo:UBERON_0006208 obo:IAO_0000115 "A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head." ; oboInOwl:hasDbXref "EHDAA2:0000155", "EHDAA:4685", "EMAPA:17280", "NCIT:C34110", "VHOG:0001364" ; oboInOwl:hasExactSynonym "auditory hillock of Hiss" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auditory tubercles", "auricular hillock", "hillock of Hiss" ; oboInOwl:id "UBERON:0006208" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "auditory hillocks" ; rdfs:subClassOf obo:UBERON_0000477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] . obo:UBERON_0006210 oboInOwl:hasDbXref "EHDAA2:0000179", "EHDAA:3217", "EMAPA:16893" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006210" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "body-wall mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000309 ] . obo:UBERON_0006211 obo:IAO_0000115 "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." ; oboInOwl:hasDbXref "EHDAA2:0000189", "EHDAA:536", "EMAPA:16259", "FMA:313607", "SCTID:361412007", "VHOG:0000380", "Wikipedia:Buccopharyngeal_membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oral membrane", "oral plate", "oropharyngeal membrane", "pharyngeal membrane" ; oboInOwl:id "UBERON:0006211" ; oboInOwl:inSubset core:emapa_ehdaa2, core:pheno_slim ; a owl:Class ; rdfs:label "buccopharyngeal membrane" ; rdfs:subClassOf obo:UBERON_0003037, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000930 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001042 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000925 ], _:genid143074 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png"^^xsd:anyURI . obo:UBERON_0006213 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a carpal bone." ; oboInOwl:hasDbXref "EHDAA2:0000221", "EHDAA:8544", "EMAPA:18102", "VHOG:0001123" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal cartilage condensation" ; oboInOwl:id "UBERON:0006213" ; a owl:Class ; rdfs:label "carpus cartilage element" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006214 ] ; owl:equivalentClass _:genid141622 . obo:UBERON_0006214 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a carpal bone." ; oboInOwl:hasDbXref "EHDAA2:0000222", "EHDAA:6324", "EMAPA:17724", "VHOG:0000955" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpal pre-cartilage condensation" ; oboInOwl:id "UBERON:0006214" ; a owl:Class ; rdfs:label "carpus pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009523 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003319 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ] . obo:UBERON_0006215 obo:IAO_0000115 "The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system." ; obo:UBPROP_0000001 "The interface between the dorsal neuroepithelium and the roofplate of the fourth ventricle. The source of a number of migratory neuron populations of the hindbrain.[TAO]" ; oboInOwl:hasAlternativeId "UBERON:0013163" ; oboInOwl:hasDbXref "DHBA:10664", "EHDAA2:0000231", "EMAPA:17074", "TAO:0001440", "Wikipedia:Rhombic_lips", "XAO:0004135", "ZFA:0001440" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellar anlage", "cerebellar primordium", "cerebellum primordium", "dorsal part of alar plate of metencephalon", "future cerebellum", "presumptive cerebellum", "rostral rhombic lip" ; oboInOwl:id "UBERON:0006215" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "rhombic lip" ; rdfs:subClassOf _:genid143104, _:genid143106 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0006217 obo:IAO_0000115 "The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings." ; obo:UBPROP_0000001 "A membrane that separates the proctodeum and the hindgut in the early embryo. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.497, see_Kardong_KV][VHOG]" ; obo:UBPROP_0000003 "In mammals, the cloaca exists as an embryonic structure that undergoes septation to become distinct urethral, anal, and genital orifices.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000257", "EHDAA:214", "EHDAA:2933", "EMAPA:16832", "FMA:295525", "NCIT:C34128", "SCTID:308826008", "UMLS:C0231056", "VHOG:0001198", "Wikipedia:Cloacal_membrane" ; oboInOwl:hasExactSynonym "embryonic cloacal membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "membrana cloacalis" ; oboInOwl:id "UBERON:0006217" ; oboInOwl:inSubset core:emapa_ehdaa2, core:pheno_slim ; a owl:Class ; rdfs:label "cloacal membrane" ; rdfs:subClassOf obo:UBERON_0000158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000163 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000163 ], _:genid143118 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray991.png"^^xsd:anyURI . obo:UBERON_0006218 oboInOwl:hasDbXref "EHDAA:1267", "EMAPA:16342", "RETIRED_EHDAA2:0000268" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006218" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "common atrial chamber" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] . obo:UBERON_0006219 oboInOwl:hasDbXref "EHDAA2:0000340", "EHDAA:6002", "EMAPA:17749" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006219" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "deltoid pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid143130, _:genid143132 . obo:UBERON_0006222 obo:IAO_0000115 "The foremost region of the future forebrain that develops into the diencephalon." ; oboInOwl:hasDbXref "EFO:0003442", "EHDAA2:0000600", "EHDAA:844", "EMAPA:16514", "RETIRED_EHDAA2:0000386", "TAO:0000574", "ZFA:0000574" ; oboInOwl:hasExactSynonym "presumptive diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006222" ; oboInOwl:inSubset core:efo_slim, core:emapa_ehdaa2, core:vertebrate_core ; a owl:Class ; rdfs:label "future diencephalon" ; rdfs:subClassOf _:genid143138 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0006224 oboInOwl:hasDbXref "EHDAA2:0000431", "EHDAA:8483", "EMAPA:17710" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006224" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "elbow joint primordium" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003318 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001490 ] . obo:UBERON_0006227 obo:IAO_0000116 "consider obsoleting, the ethmoid is endochondral?" ; oboInOwl:hasDbXref "EHDAA2:0000456", "EHDAA:8363", "EMAPA:18023", "FMA:312597" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006227" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "ethmoid bone primordium" ; rdfs:subClassOf _:genid143148, _:genid143150, _:genid143152 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001679 ] ) ] . obo:UBERON_0006230 oboInOwl:hasDbXref "EHDAA2:0000483", "EHDAA:2925", "EMAPA:17845" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006230" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "extrinsic ocular pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid143154, _:genid143156 . obo:UBERON_0006232 oboInOwl:hasDbXref "EHDAA:1477", "EMAPA:16660", "RETIRED_EHDAA2:0000496", "VHOG:0000715" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facio-acoustic preganglion complex" ; oboInOwl:id "UBERON:0006232" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "facio-acoustic VII-VIII preganglion complex" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005565 ], _:genid143158 . obo:UBERON_0006233 obo:IAO_0000115 "A differentiated genital tubercle that is part of a female reproductive system." ; oboInOwl:hasDbXref "EHDAA:8118", "EMAPA:18680", "RETIRED_EHDAA2:0000500", "VHOG:0000666" ; oboInOwl:hasExactSynonym "genital tubercle of female" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006233" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "female genital tubercle" ; rdfs:subClassOf _:genid143166 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011757 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0006234 obo:IAO_0000115 "A femur endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0000508", "EMAPA:17502", "VHOG:0000951" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "femoral pre-cartilage condensation" ; oboInOwl:id "UBERON:0006234" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "femur pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015052 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006235 obo:IAO_0000115 "An anatomical junctions that overlaps the foregut and midgut." ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000569", "EHDAA:526", "EMAPA:16363", "VHOG:0000291" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006235" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "foregut-midgut junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001041 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0006236 oboInOwl:hasDbXref "EHDAA2:0000577", "EHDAA:9540", "EMAPA:18017", "FMA:312589" ; oboInOwl:hasExactSynonym "frontal bone primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006236" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "tetrapod frontal bone primordium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000209 ] ) ] . obo:UBERON_0006238 obo:IAO_0000115 "The embryonic precursor of the brain." ; obo:UBPROP_0000001 "The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO)" ; oboInOwl:hasDbXref "BAMS:Enc", "BTO:0004726", "EFO:0003431", "EHDAA:300", "EHDAA:830", "EMAPA:16089", "FMA:312967", "RETIRED_EHDAA2:0000591", "TAO:0000146", "ZFA:0000146" ; oboInOwl:hasExactSynonym "brain rudiment", "presumptive brain" ; oboInOwl:hasNarrowSynonym "encephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic brain" ; oboInOwl:id "UBERON:0006238" ; oboInOwl:inSubset core:cumbo, core:efo_slim, core:emapa_ehdaa2, core:vertebrate_core ; a owl:Class ; rdfs:label "future brain" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002346 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:UBERON_0006240 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a forebrain." ; obo:IAO_0000116 "TODO. Add relationships to neural plate (both ZFA and EMAPA time this with the neural plate)" ; oboInOwl:hasDbXref "BAMS:Pros", "EFO:0003423", "EHDAA2:0000661", "EHDAA:2643", "EMAPA:16640", "TAO:0000062", "Wikipedia:Prosencephalon", "ZFA:0000062" ; oboInOwl:hasExactSynonym "future prosencephalon", "presumptive forebrain", "presumptive prosencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prosencephalon" ; oboInOwl:id "UBERON:0006240" ; oboInOwl:inSubset core:efo_slim, core:emapa_ehdaa2, core:vertebrate_core ; a owl:Class ; rdfs:label "future forebrain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0006241 oboInOwl:hasDbXref "EFO:0003438", "EHDAA2:0000674", "EHDAA:898", "EMAPA:16092", "EMAPA:16755", "TAO:0000417", "ZFA:0000417" ; oboInOwl:hasExactSynonym "presumptive spinal cord", "presumptive spinal cord neural keel", "presumptive spinal cord neural plate", "presumptive spinal cord neural rod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006241" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "future spinal cord" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002240 ], _:genid143210 . obo:UBERON_0006242 obo:IAO_0000115 "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." ; oboInOwl:hasDbXref "EHDAA2:0000700", "EHDAA:3047", "EMAPA:16713", "XAO:0004205" ; oboInOwl:hasExactSynonym "gall bladder primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006242" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "gallbladder primordium" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid143222, _:genid143224 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0006244 oboInOwl:hasDbXref "EHDAA2:0000785", "EHDAA:8462", "EMAPA:17739" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006244" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "hip joint primordium" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003320 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001486 ] . obo:UBERON_0006245 obo:IAO_0000115 "A humerus endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0000787", "EHDAA:6240", "EMAPA:17713", "VHOG:0001120" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "humeral cartilage condensation" ; oboInOwl:id "UBERON:0006245" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "humerus cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000976 ], _:genid143233, _:genid143235, _:genid143237 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015053 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006246 obo:IAO_0000115 "A humerus endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0000788", "EHDAA:4192", "EMAPA:17427", "VHOG:0000950" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "humeral pre-cartilage condensation" ; oboInOwl:id "UBERON:0006246" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "humerus pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000976 ], _:genid143246, _:genid143248 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015053 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006247 obo:IAO_0000115 "An iliac endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0000809", "EHDAA:9568", "EMAPA:18029", "VHOG:0000964" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006247" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "iliac pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid143257, _:genid143259 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015054 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006248 obo:IAO_0000115 "An incus endochondral element that is composed primarily of a pre-cartilage condensation." ; obo:IAO_0000116 "in EHDAA2 this develops from both mandibular and maxillary mesenchyme. We have still to extend homology relationships from quadrate/incus to their ontogenic precursors (" ; oboInOwl:hasDbXref "EHDAA2:0000813", "EHDAA:9024", "EMAPA:17825", "VHOG:0000957" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006248" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "incus pre-cartilage condensation" ; rdfs:subClassOf _:genid143266 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015017 _:genid141778 ) ] . obo:UBERON_0006254 obo:IAO_0000115 "An ischial endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0000890", "EHDAA:9570", "EMAPA:26930" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ischial cartilage condensation" ; oboInOwl:id "UBERON:0006254" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "ischial cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, _:genid143274, _:genid143276 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015056 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006255 obo:IAO_0000115 "An ischial endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0000891", "EHDAA:7153", "EMAPA:18348", "VHOG:0000962" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006255" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "ischial pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid143285 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015056 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006256 oboInOwl:hasDbXref "EHDAA2:0000897", "EHDAA:8467", "EMAPA:17740" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006256" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "knee joint primordium" ; rdfs:subClassOf obo:UBERON_0001048, obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003321 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001485 ] . obo:UBERON_0006260 obo:UBPROP_0000001 "Primordium of the tongue; the median swelling and the distal and proximal swellings arise from the ventral aspect of the stomodeum. [TFD][VHOG]" ; obo:UBPROP_0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000996", "EMAPA:17186", "VHOG:0000449" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lingual swelling" ; oboInOwl:id "UBERON:0006260" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:comment "the collection consisting of the two lateral swellings and the medial swelling" ; rdfs:label "lingual swellings" ; rdfs:subClassOf obo:UBERON_0005423, obo:UBERON_0010188, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ], _:genid143292 . obo:UBERON_0006261 obo:IAO_0000115 "A differentiated genital tubercle that is part of a male reproductive system." ; oboInOwl:hasDbXref "EHDAA:8138", "EMAPA:17969", "RETIRED_EHDAA2:0001048", "VHOG:0000667" ; oboInOwl:hasExactSynonym "genital tubercle of male" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "penis anlage" ; oboInOwl:id "UBERON:0006261" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "male genital tubercle" ; rdfs:subClassOf _:genid143302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011757 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0006262 obo:IAO_0000115 "A malleus endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0001055", "EHDAA:9026", "EMAPA:17826", "VHOG:0000958" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006262" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "malleus pre-cartilage condensation" ; rdfs:subClassOf _:genid143311 ; owl:equivalentClass _:genid141815 . obo:UBERON_0006263 obo:UBPROP_0000011 "NC contributes in EHDAA2. editor note: TODO use EHDAA2 structure" ; oboInOwl:hasDbXref "EHDAA2:0001074", "EMAPA:17358", "VHOG:0001121" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006263" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "Meckel's cartilage pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005423, obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003107 ], _:genid143315, _:genid143317 . obo:UBERON_0006264 obo:IAO_0000115 "An anatomical junctions that overlaps the mouth and foregut." ; oboInOwl:hasDbXref "EHDAA:534", "EMAPA:16258", "RETIRED_EHDAA2:0001205", "VHOG:0000592" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006264" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mouth-foregut junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000165 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001041 ] ) ] . obo:UBERON_0006266 obo:IAO_0000115 "Groove between maxillary prominence and lateral nasal process." ; oboInOwl:hasDbXref "EHDAA2:0001238", "EHDAA:4770", "EMAPA:16679", "FMA:300055", "NCIT:C34218", "UMLS:C1513875", "VHOG:0001307", "Wikipedia:Lacrimal_groove" ; oboInOwl:hasExactSynonym "naso-lacrimal groove" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "s. lacrimalis maxillae" ; oboInOwl:id "UBERON:0006266" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:comment "On the nasal surface of the body of the maxilla, in front of the opening of the sinus is a deep groove, the lacrimal groove (or lacrimal sulcus), which is converted into the nasolacrimal canal, by the lacrimal bone and inferior nasal concha; this canal opens into the inferior meatus of the nose and transmits the nasolacrimal duct[WP] See also: oblique facial cleft" ; rdfs:label "nasolacrimal groove" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004067 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005868 ], _:genid143329, _:genid143331, _:genid143334 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray163.png"^^xsd:anyURI . obo:UBERON_0006267 obo:IAO_0000115 "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." ; obo:IAO_0000116 "TODO - check ordering; awaiting confirmation from JB" ; obo:UBPROP_0000001 "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001278", "EHDAA:264", "EMAPA:16101", "NCIT:C34231", "UMLS:C1518429", "VHOG:0001212" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006267" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "notochordal plate" ; rdfs:subClassOf obo:UBERON_0000490, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid143344 . obo:UBERON_0006268 obo:IAO_0000115 "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot." ; oboInOwl:hasDbXref "EHDAA2:0001279", "EHDAA:224", "EMAPA:16102", "FMA:293135", "NCIT:C34232", "UMLS:C1518430", "VHOG:0001213" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chordamesoderm", "presumptive notochord" ; oboInOwl:id "UBERON:0006268" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:comment "The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus." ; rdfs:label "notochordal process" ; rdfs:subClassOf obo:UBERON_0005423, _:genid143349 . obo:UBERON_0006271 obo:IAO_0000115 "Either of two openings transmitting nerves and blood vessels to or from the orbit." ; oboInOwl:hasDbXref "EHDAA2:0001328", "EHDAA:10648", "EMAPA:18717", "SCTID:280546005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006271" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "orbital fissure" ; rdfs:subClassOf _:genid143357 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001697 ] ) ] . obo:UBERON_0006273 obo:IAO_0000115 "The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles." ; obo:UBPROP_0000001 "A depression appearing in each otic placode, marking the beginnning of embryonic development of the internal ear. [TFD][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0009123" ; oboInOwl:hasDbXref "EHDAA2:0001336", "EHDAA:929", "EMAPA:16536", "FMA:302911", "NCIT:C34238", "VHOG:0001147", "Wikipedia:Otic_pit" ; oboInOwl:hasExactSynonym "otic cup" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006273" ; oboInOwl:inSubset core:emapa_ehdaa2, core:pheno_slim ; a owl:Class ; rdfs:label "otic pit" ; rdfs:subClassOf obo:UBERON_0016566, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003069 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003051 ] . obo:UBERON_0006274 oboInOwl:hasDbXref "EHDAA2:0001404", "EHDAA:9544", "EMAPA:18019", "FMA:312593" ; oboInOwl:hasExactSynonym "parietal bone primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006274" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "tetrapod parietal bone primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000210 ] ) ] . obo:UBERON_0006279 obo:IAO_0000115 "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity." ; obo:UBPROP_0000001 "Each of the canal that links the peritoneal cavity and the caudal part of a pleural cavity. [ISBN:0124020607][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001481", "EHDAA:4128", "EMAPA:17704", "EMAPA:17707", "SCTID:361413002", "VHOG:0001505" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pleuroperitoneal channel" ; oboInOwl:id "UBERON:0006279" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "pleuroperitoneal canal" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid143380 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003914 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001179 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002402 ] ) ] . obo:UBERON_0006283 obo:IAO_0000115 "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." ; oboInOwl:hasAlternativeId "UBERON:0010226" ; oboInOwl:hasBroadSynonym "embryonic ventricle" ; oboInOwl:hasDbXref "EHDAA2:0001531", "EMAPA:16350", "FMA:71006", "NCIT:C34160", "SCTID:361524003", "TAO:0002231", "Wikipedia:Embryonic_ventricle", "ZFA:0001719" ; oboInOwl:hasExactSynonym "early heart ventricle", "embryonic heart ventricle", "future heart ventricle", "presumptive cardiac ventricle heart tube", "primitive ventricle", "primitive ventricle of heart", "primordial cardiac ventricle", "primordial ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006283" ; a owl:Class ; rdfs:comment "The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP]" ; rdfs:label "future cardiac ventricle" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002082 ], _:genid143386, _:genid143388 . obo:UBERON_0006284 obo:IAO_0000115 "Future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle." ; obo:UBPROP_0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" ; oboInOwl:hasDbXref "DHBA:10595", "EHDAA2:0001571", "EHDAA:1356", "EMAPA:16521", "SCTID:361480006", "TAO:0001259", "VHOG:0000644", "ZFA:0001259" ; oboInOwl:hasExactSynonym "prosencephalic vesicle" ; oboInOwl:hasNarrowSynonym "preevaginated forebrain vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "forebrain ventricle", "forebrain vesicle", "prosencephalic ventricle" ; oboInOwl:id "UBERON:0006284" ; a owl:Class ; rdfs:label "early prosencephalic vesicle" ; rdfs:subClassOf obo:UBERON_0013150, _:genid143397 . obo:UBERON_0006285 obo:IAO_0000115 "A pubic endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0001574", "EHDAA:9572", "EMAPA:18349", "VHOG:0000965" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006285" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "pubic pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid143410 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015055 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006286 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a radius bone." ; oboInOwl:hasDbXref "EHDAA2:0001585", "EHDAA:7267", "EMAPA:18054", "VHOG:0001318" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006286" ; a owl:Class ; rdfs:label "radius cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010846 ], _:genid143417 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015001 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006287 obo:IAO_0000115 "A radius-ulna endochondral element that is composed primarily of a pre-cartilage condensation." ; obo:UBPROP_0000012 "EMAPA has a separate radius-ulna cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0001587", "EHDAA:4178", "EMAPA:17420", "VHOG:0000949" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006287" ; a owl:Class ; rdfs:label "radius-ulna pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015002 _:genid141917 ) ] . obo:UBERON_0006288 obo:IAO_0000115 "A rib endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001716", "EHDAA:8347", "EMAPA:17678", "VHOG:0001122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006288" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "rib cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002228 ], _:genid143434 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015019 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006289 obo:IAO_0000115 "A rib endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0001717", "EHDAA:6026", "EMAPA:17397", "VHOG:0000681" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006289" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "rib pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002228 ], _:genid143443 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015019 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006290 obo:IAO_0000115 "A scapula endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001777", "EHDAA:8368", "EMAPA:18343", "VHOG:0001125" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006290" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "scapula cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0006849 ], _:genid143452, _:genid143454 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015057 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006291 obo:IAO_0000115 "A scapula endochondral element that is composed primarily of a pre-cartilage condensation." ; obo:UBPROP_0000011 "the scapula has been shown to develop from multiple tissues, such as the dermomyotome of the somites, the mesodermal portion of the soma- topleure (a domain of the lateral plate mesoderm or LPM) and neural crest cell-derived mesenchyme (Huang et al., 2000; Matsuoka et al., 2005; Wang et al., 2005)." ; oboInOwl:hasDbXref "EHDAA2:0001778", "EHDAA:6041", "EMAPA:18027", "VHOG:0000960" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006291" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "scapula pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0006849 ], _:genid143462, _:genid143464 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015057 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006292 obo:UBPROP_0000012 "this is part of the forelimb skeleton in EHDAA2, but this violates part-disjointness" ; oboInOwl:hasDbXref "EHDAA2:0001836", "EHDAA:8493", "EMAPA:17712" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006292" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "shoulder joint primordium" ; rdfs:subClassOf obo:UBERON_0005856, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003322 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001470 ], _:genid143471 . obo:UBERON_0006293 obo:IAO_0000115 "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." ; obo:UBPROP_0000012 "check difference between splenic and spleen in EMAPA; note that in EHDAA2 the class 'spleen' refers to the mesenchyme" ; oboInOwl:hasAlternativeId "UBERON:0009750" ; oboInOwl:hasDbXref "EHDAA2:0001904", "EHDAA:3003", "EMAPA:18535", "XAO:0000326" ; oboInOwl:hasExactSynonym "spleen mesenchyme", "splenic mesenchyme", "splenic primordium" ; oboInOwl:hasNarrowSynonym "left spleen primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006293" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spleen primordium" ; rdfs:subClassOf obo:UBERON_0001048, obo:UBERON_0003104, _:genid143476, _:genid143478 . obo:UBERON_0006294 obo:IAO_0000115 "A stapes endochondral element that is composed primarily of a pre-cartilage condensation." ; obo:UBPROP_0000011 "independent of the mesenchymal condensation that will form the otic capsule" ; oboInOwl:hasDbXref "EHDAA2:0001910", "EHDAA:5699", "EMAPA:17827", "VHOG:0000956" ; oboInOwl:hasExactSynonym "stapedial anlage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006294" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "stapes pre-cartilage condensation" ; rdfs:subClassOf _:genid143490, _:genid143492 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015016 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0006295 oboInOwl:hasDbXref "EHDAA2:0001912", "EHDAA:9565", "EMAPA:18345", "VHOG:0000961" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006295" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "sternebral bone pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ], _:genid143498 . obo:UBERON_0006297 obo:IAO_0000115 "A primordium that has the potential to develop into a sublingual gland." ; oboInOwl:hasDbXref "EHDAA2:0001935", "EHDAA:7989", "EMAPA:17752" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006297" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "sublingual gland primordium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001832 ] ) ] . obo:UBERON_0006298 obo:IAO_0000115 "A primordium that has the potential to develop into a submandibular gland." ; oboInOwl:hasDbXref "EHDAA2:0001939", "EHDAA:9255", "EMAPA:17755" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submaxillary gland primordium" ; oboInOwl:id "UBERON:0006298" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "submandibular gland primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002424 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0006905 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001736 ] ) ] . obo:UBERON_0006304 oboInOwl:hasDbXref "EHDAA:924", "EMAPA:16663", "RETIRED_EHDAA2:0002089" ; oboInOwl:hasExactSynonym "trigeminal V preganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trigeminal preganglion" ; oboInOwl:id "UBERON:0006304" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:comment "See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model" ; rdfs:label "future trigeminal ganglion" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005563 ], _:genid141997, _:genid143517 . obo:UBERON_0006306 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a ulna." ; oboInOwl:hasDbXref "EHDAA2:0002098", "EHDAA:7269", "EMAPA:18055", "VHOG:0001155" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006306" ; a owl:Class ; rdfs:label "ulna cartilage element" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010847 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015003 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0006311 obo:IAO_0000115 "A segment of the eyeball that is filled with refractive media." ; oboInOwl:hasDbXref "BTO:0002085", "EMAPA:37529", "FMA:58071", "MA:0002459", "NCIT:C32301", "SCTID:280540004", "UMLS:C0459556" ; oboInOwl:hasExactSynonym "eye chamber", "eyeball chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chamber of eye" ; oboInOwl:id "UBERON:0006311" ; a owl:Class ; rdfs:label "chamber of eyeball" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0006312 ] ) ] . obo:UBERON_0006312 obo:IAO_0000115 "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light." ; obo:UBPROP_0000009 "ocular refraction" ; oboInOwl:hasDbXref "MA:0001911" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006312" ; a owl:Class ; rdfs:label "ocular refractive media" ; rdfs:subClassOf obo:UBERON_0000463, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] . obo:UBERON_0006314 obo:IAO_0000115 "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." ; oboInOwl:hasBroadSynonym "fluid" ; oboInOwl:hasDbXref "BIRNLEX:20", "EMAPA:37441", "FMA:280556", "GAID:266", "MESH:D001826", "Wikipedia:Body_fluid", "galen:BodyFluid" ; oboInOwl:hasExactSynonym "body fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006314" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bodily fluid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ] ) ] . obo:UBERON_0006320 obo:IAO_0000115 "Thin, narrow muscle placed near the anterior margin of the floor of the orbit." ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010117", "FMA:49040", "MA:0001276", "NCIT:C32783", "SCTID:181156006", "TAO:0000861", "UMLS:C0582817", "VHOG:0001132", "Wikipedia:Inferior_oblique_muscle", "ZFA:0000861" ; oboInOwl:hasExactSynonym "inferior oblique", "inferior oblique muscle", "m. obliquus inferior", "musculus obliquus inferior", "musculus obliquus inferior bulbi", "obliquus inferior", "obliquus oculi inferior", "ventral oblique extraocular muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus obliquus inferior bulbi", "ventral oblique extraocular muscles" ; oboInOwl:id "UBERON:0006320" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:comment "Taxon notes (via VHOG): \"The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.\" Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective, Third Edition (2001) Orlando Fla.: Harcourt College Publishers, p.331" ; rdfs:label "inferior oblique extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006532, _:genid143551, _:genid143553, _:genid143555 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0006321 obo:IAO_0000115 "The superior oblique muscle, or obliquus oculi superior, is a fusiform muscle in the upper, medial side of the orbit whose primary action is downward, lateral rotation of the eye. One of the extraocular muscles, the superior oblique is the only muscle innervated by the trochlear nerve (the fourth cranial nerve)." ; obo:UBPROP_0000001 "Cranial nerve IV innervated; dorsal in the obliquus group.[AAO]" ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010119", "FMA:49039", "MA:0001277", "NCIT:C33688", "SCTID:181155005", "TAO:0000738", "UMLS:C0582816", "VHOG:0001131", "Wikipedia:Superior_oblique_muscle", "ZFA:0000738" ; oboInOwl:hasExactSynonym "dorsal oblique extraocular muscle", "musculus obliquus superior", "obliquus superior", "superior oblique", "superior oblique muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "M. obliquus superior", "dorsal oblique extraocular muscles", "musculus obliquus superior bulbi", "obliquus oculi superior" ; oboInOwl:id "UBERON:0006321" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "superior oblique extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006532, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0014796 ], _:genid143569, _:genid143572 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0006322 obo:IAO_0000115 "A muscle in the orbit that depresses, adducts, and helps extort (rotate laterally) the eye. The inferior rectus muscle is the only muscle that is capable of depressing the pupil when it is in a fully abducted position." ; obo:UBPROP_0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; oboInOwl:hasDbXref "AAO:0010101", "FMA:49036", "MA:0001279", "NCIT:C32790", "SCTID:181154009", "TAO:0000457", "UMLS:C0582819", "VHOG:0001130", "Wikipedia:Inferior_rectus_muscle", "ZFA:0000457" ; oboInOwl:hasExactSynonym "inferior rectus", "inferior rectus muscle", "m. rectus inferior", "musculus rectus inferior", "ventral rectus extraocular muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus rectus inferior bulbi", "ventral recti", "ventral rectus" ; oboInOwl:id "UBERON:0006322" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "inferior rectus extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006533 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png"^^xsd:anyURI . obo:UBERON_0006325 oboInOwl:hasDbXref "EMAPA:37628", "FMA:72058", "MA:0001757", "SCTID:279557001" ; oboInOwl:hasExactSynonym "intrinsic ligament of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006325" ; a owl:Class ; rdfs:label "laryngeal intrinsic ligament" ; rdfs:subClassOf obo:UBERON_0001743 . obo:UBERON_0006328 oboInOwl:hasDbXref "EMAPA:37630", "FMA:55226", "MA:0001770", "SCTID:244810002" ; oboInOwl:hasExactSynonym "intrinsic laryngeal muscle", "intrinsic muscle of larynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intrinsic laryneal muscles" ; oboInOwl:id "UBERON:0006328" ; a owl:Class ; rdfs:label "laryngeal intrinsic muscle" ; rdfs:subClassOf obo:UBERON_0001568 . obo:UBERON_0006331 obo:IAO_0000115 "A nucleus of brain that is part of a brainstem." ; oboInOwl:hasDbXref "EMAPA:32790", "MA:0000821" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain stem nucleus" ; oboInOwl:id "UBERON:0006331" ; a owl:Class ; rdfs:label "brainstem nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ] ) ] . obo:UBERON_0006333 obo:IAO_0000115 "." ; obo:UBPROP_0000001 "Surface structure that is the region of the head in front of and between the orbits, and above the lower jaw. Nares are located on the snout[ZFA]." ; oboInOwl:hasDbXref "EMAPA:32806", "MA:0001910", "SCTID:41127006", "TAO:0001712", "Wikipedia:Snout", "ZFA:0005496" ; oboInOwl:hasNarrowSynonym "muzzle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006333" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "snout" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004089 ] . obo:UBERON_0006338 obo:IAO_0000115 "A choroid plexus stroma that is part of a lateral ventricle." ; obo:IAO_0000116 "definitions should be fixed to use generic stroma class" ; oboInOwl:hasDbXref "MA:0000963" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006338" ; a owl:Class ; rdfs:label "lateral ventricle choroid plexus stroma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002307 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005206 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:UBERON_0006339 obo:IAO_0000115 "A choroid plexus stroma that is part of a third ventricle." ; oboInOwl:hasDbXref "EMAPA:37056", "MA:0000881" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006339" ; a owl:Class ; rdfs:label "third ventricle choroid plexus stroma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002288 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005206 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ) ] . obo:UBERON_0006340 obo:IAO_0000115 "A choroid plexus stroma that is part of a fourth ventricle." ; oboInOwl:hasDbXref "MA:0000985" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006340" ; a owl:Class ; rdfs:label "fourth ventricle choroid plexus stroma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002290 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid142101 ] . obo:UBERON_0006347 obo:IAO_0000115 "An artery that connects two larger arteries." ; oboInOwl:hasDbXref "EMAPA:18598", "MA:0001938", "NCIT:C52851", "UMLS:C1707451" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006347" ; a owl:Class ; rdfs:comment "Grouping for anterior and posterior" ; rdfs:label "communicating artery" ; rdfs:subClassOf obo:UBERON_0001637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onClass obo:UBERON_0001637 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0006349 obo:IAO_0000115 "An external iliac artery branch that supplies blood to the anterior abdominal wall." ; oboInOwl:hasDbXref "EMAPA:18750", "MA:0001948", "MESH:D019074", "NCIT:C52860", "SCTID:261400009", "UMLS:C0282640", "Wikipedia:Epigastric_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006349" ; a owl:Class ; rdfs:label "epigastric artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0006635 ] ) ] . obo:UBERON_0006355 obo:IAO_0000116 "inferred from artery" ; oboInOwl:hasDbXref "EMAPA:18646", "MA:0002227" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006355" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "superior vesical vein" ; rdfs:subClassOf obo:UBERON_0002460 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0006356 obo:IAO_0000115 "A vein that drains the anterior abdominal wall." ; oboInOwl:hasDbXref "EMAPA:18759", "MA:0002114", "NCIT:C53045", "UMLS:C1707930", "Wikipedia:Epigastric_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006356" ; a owl:Class ; rdfs:label "epigastric vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0006635 ] ) ] . obo:UBERON_0006430 obo:IAO_0000115 "A costal cartilage that is part of a xiphoid process." ; obo:UBPROP_0000001 "Distal, cartilaginous portion of the sternum.[AAO]" ; oboInOwl:hasDbXref "AAO:0000940", "EMAPA:18725", "FMA:32574", "MA:0001884" ; oboInOwl:hasExactSynonym "cartilage of xiphoid process", "xiphoid cartilage", "xiphoid process cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ensiform cartilage" ; oboInOwl:id "UBERON:0006430" ; oboInOwl:inSubset core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "xiphoid cartilage" ; rdfs:subClassOf obo:UBERON_0000398 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002236 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002207 ] ) ] . obo:UBERON_0006431 obo:IAO_0000115 "A bone tissue that is part of a xiphoid process." ; oboInOwl:hasDbXref "FMA:32577", "GAID:248" ; oboInOwl:hasExactSynonym "bone tissue of xiphoid process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "xiphoid bone" ; oboInOwl:id "UBERON:0006431" ; a owl:Class ; rdfs:label "xiphoid process bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002207 ] ) ] . obo:UBERON_0006435 obo:IAO_0000115 "The unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species." ; obo:UBPROP_0000008 "found in most mammals, with the exception of humans" ; oboInOwl:hasDbXref "EMAPA:29769", "MA:0000406", "SCTID:27962002", "Wikipedia:Baculum" ; oboInOwl:hasExactSynonym "baculum", "os baculum", "penile bone", "penis bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006435" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "os penis" ; rdfs:subClassOf obo:UBERON_0007719 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0006440 obo:IAO_0000115 "The ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans; it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals." ; oboInOwl:hasDbXref "EMAPA:30823", "MA:0000387" ; oboInOwl:hasExactSynonym "baubellum", "clitoral bone", "clitoris bone", "os clitoridis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006440" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "os clitoris" ; rdfs:subClassOf obo:UBERON_0007719, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001434 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002411 ], [ a owl:Restriction ; owl:onProperty core:sexually_homologous_to ; owl:someValuesFrom obo:UBERON_0006435 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] . obo:UBERON_0006444 obo:IAO_0000115 "A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart)." ; oboInOwl:hasBroadSynonym "anulus" ; oboInOwl:hasDbXref "BTO:0003627", "EMAPA:32670", "FMA:76704", "MESH:D000070616" ; oboInOwl:hasExactSynonym "anulus fibrosus", "fibrocartilaginous ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibrous ring" ; oboInOwl:id "UBERON:0006444" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "annulus fibrosus" ; rdfs:subClassOf obo:UBERON_0001995 . obo:UBERON_0006497 obo:IAO_0000115 "Any of the interosseous muscles of the pes (foot). Includes the plantar and dorsal interossei." ; obo:UBPROP_0000001 "Interroseous muscles are short digital muscles found together on the plantar aspect of the hindlimb. They act as shock absorbers for the pes, and closely resemble the interossei found in the forelimb. They originate from the proximal ends of all metatarsal bones and initially insert on the sesamoid bones at the metatarsophalangeal joints. The interosseous are then continued by distal sesamoidean ligaments which join the extensor tendons and attach to the phalanges[MURDOCH:920]." ; oboInOwl:hasDbXref "EMAPA:36262", "FMA:37456", "MA:0002302", "NCIT:C53172", "SCTID:181714004", "UMLS:C0448494" ; oboInOwl:hasExactSynonym "foot interosseous", "foot interosseus muscle", "interosseous of foot", "pes interosseous muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interosseous muscle of foot" ; oboInOwl:id "UBERON:0006497" ; a owl:Class ; rdfs:label "interosseous muscle of pes" ; rdfs:subClassOf obo:UBERON_0014378, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001448 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003868 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006508 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0006508 obo:IAO_0000115 "Any of the muscles of the autopod region that lie between metacarpal or metatarsal bones." ; oboInOwl:hasBroadSynonym "interosseous" ; oboInOwl:hasDbXref "Wikipedia:Interossei" ; oboInOwl:hasExactSynonym "interosseus muscle", "m. interosseous" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interossei" ; oboInOwl:id "UBERON:0006508" ; a owl:Class ; rdfs:label "interosseous muscle of autopod" ; rdfs:subClassOf obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009877 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0003821 ], _:genid143710 . obo:UBERON_0006514 obo:IAO_0000115 "Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum." ; obo:RO_0002171 obo:UBERON_0002435 ; oboInOwl:hasDbXref "BAMS:PAL", "EMAPA:32780", "FMA:83684", "MA:0000889", "MBA:803", "neuronames:2673" ; oboInOwl:hasExactSynonym "neuraxis pallidum", "pallidum of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006514" ; a owl:Class ; rdfs:label "pallidum" ; rdfs:subClassOf obo:UBERON_0002020, _:genid143715 . obo:UBERON_0006517 obo:IAO_0000115 "Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211)." ; obo:UBPROP_0000007 "calyceal" ; oboInOwl:hasBroadSynonym "calyx" ; oboInOwl:hasDbXref "EMAPA:18676", "FMA:284558", "GAID:427", "MA:0000369", "MESH:D007670", "NCIT:C12927", "SCTID:276832000", "UMLS:C0022651" ; oboInOwl:hasExactSynonym "calices renales", "renal calix", "renal calyx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calices renales" ; oboInOwl:id "UBERON:0006517" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "kidney calyx" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001224 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001224 ] . obo:UBERON_0006524 obo:IAO_0000115 "System pertaining to a bronchus and alveoli." ; oboInOwl:hasDbXref "BTO:0000136", "CALOHA:TS-1296", "EMAPA:32692", "MA:0000416" ; oboInOwl:hasExactSynonym "pulmonary alveolar system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchoalveolar system" ; oboInOwl:id "UBERON:0006524" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "alveolar system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002048 ] . obo:UBERON_0006525 oboInOwl:hasDbXref "EMAPA:19001", "MA:0001775" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006525" ; a owl:Class ; rdfs:label "left lung alveolar system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006524 ] . obo:UBERON_0006526 oboInOwl:hasDbXref "EMAPA:35717", "MA:0001784" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006526" ; a owl:Class ; rdfs:label "right lung alveolar system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006524 ] . obo:UBERON_0006530 obo:IAO_0000115 "A substance formed from the secretion of one or more glands of the male genital tract in which sperm cells are suspended." ; obo:IAO_0000232 "this ontology contains a number of subtypes of seminal fluid, defined according to glands (which are more taxonomically restricted)", "we follow FMA and make this class a generic superclass of the secretions of different glands (prostate, bulbo-urethreal, seminal vesicle). MA (and ncit) follows a mixture model, where these secretions are part of the seminal fluid" ; obo:UBPROP_0000008 "This term covers a variety of species. Example: In D. melanogaster, seminal fluid proteins affect female receptivity, ovulation, oogenesis, sperm storage, sperm competition and mating plug formation" ; obo:UBPROP_0000009 "seminal fluid may have a role in sperm capacitation, sperm motility" ; oboInOwl:hasDbXref "BTO:0001232", "CALOHA:TS-0918", "EMAPA:36543", "FMA:62967", "MA:0002523", "MAT:0000057", "MIAA:0000057" ; oboInOwl:hasExactSynonym "seminal plasma" ; oboInOwl:hasNarrowSynonym "milt" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male genital fluid", "male genital secretion", "seminal fluid" ; oboInOwl:id "UBERON:0006530" ; a owl:Class ; rdfs:label "seminal fluid" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0048240 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_1902093 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001968 ] [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0005399 ] ) ] . obo:UBERON_0006531 obo:IAO_0000115 "The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris." ; obo:UBPROP_0000012 "we follow MA in making this a subclass of extra-ocular muscle but the distinction is not clear" ; oboInOwl:hasDbXref "CALOHA:TS-0305", "MA:0002432", "MESH:D009801", "NCIT:C33199", "UMLS:C0028863" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006531" ; a owl:Class ; rdfs:label "oculomotor muscle" ; rdfs:subClassOf obo:UBERON_0001601 . obo:UBERON_0006532 oboInOwl:hasDbXref "FMA:312383", "MA:0001275" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006532" ; a owl:Class ; rdfs:label "oblique extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006531 . obo:UBERON_0006533 oboInOwl:hasDbXref "FMA:312408", "MA:0001278" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006533" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "rectus extraocular muscle" ; rdfs:subClassOf obo:UBERON_0006531, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0014796 ] . obo:UBERON_0006535 obo:IAO_0000115 "A portion of organism substance that secreted_by a zone of skin." ; oboInOwl:hasDbXref "MA:0002537" ; oboInOwl:hasExactSynonym "skin fluid/secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin fluid", "skin substance" ; oboInOwl:id "UBERON:0006535" ; a owl:Class ; rdfs:label "skin secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000014 ] ) ] . obo:UBERON_0006536 obo:IAO_0000115 "A portion of organism substance that is secreted by a male reproductive gland." ; oboInOwl:hasDbXref "EMAPA:36541", "MA:0002521" ; oboInOwl:hasExactSynonym "male reproductive system fluid/secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male reproductive system fluid", "male reproductive system secretion" ; oboInOwl:id "UBERON:0006536" ; a owl:Class ; rdfs:label "male reproductive gland secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0005399 ] ) ] . obo:UBERON_0006537 obo:IAO_0000115 "A portion of organism substance that is secreted by a female reproductive gland." ; oboInOwl:hasDbXref "MA:0002510" ; oboInOwl:hasExactSynonym "female reproductive system fluid/secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "female reproductive system fluid", "female reproductive system secretion" ; oboInOwl:id "UBERON:0006537" ; a owl:Class ; rdfs:label "female reproductive gland secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0005398 ] ) ] . obo:UBERON_0006538 obo:IAO_0000115 "A portion of organism substance that secreted_by a respiratory system." ; oboInOwl:hasDbXref "EMAPA:36550", "MA:0002533", "NCIT:C13722", "UMLS:C1514899" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "respiratory system fluid", "respiratory system secretion" ; oboInOwl:id "UBERON:0006538" ; a owl:Class ; rdfs:label "respiratory system fluid/secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0006539 obo:IAO_0000115 "A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards." ; oboInOwl:hasDbXref "EMAPA:36538", "MA:0002505" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lactiferous gland fluid", "lactiferous gland secretion", "mammary gland fluid", "mammary gland secreted fluid", "mammary gland secretion", "secretion of mammary gland" ; oboInOwl:id "UBERON:0006539" ; a owl:Class ; rdfs:label "mammary gland fluid/secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0006544 obo:IAO_0000115 "A vasculature that is part of a kidney." ; oboInOwl:hasDbXref "EMAPA:28457", "TAO:0005305", "ZFA:0005305" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006544" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "kidney vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0006553 obo:IAO_0000115 "A tube in the kidney that collect and transport urine." ; obo:UBPROP_0000012 "in ZFA this is defined as part of mesonephros" ; oboInOwl:hasDbXref "TAO:0005289", "ZFA:0005289" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006553" ; a owl:Class ; rdfs:label "renal duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0006555 obo:IAO_0000115 "A tube that is part of a excretory system." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006555" ; a owl:Class ; rdfs:label "excretory tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000025 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ] ) ] . obo:UBERON_0006558 obo:IAO_0000115 "An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system." ; obo:IAO_0000116 "consider merging with lymph vasculature" ; obo:UBPROP_0000001 "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" ; obo:UBPROP_0000007 "lymporeticular" ; obo:UBPROP_0000012 "in FMA this is part of the cardiovascular system, but here we treat the CV system as a separate component of the circulatory system from the lymphatic system" ; oboInOwl:hasDbXref "AAO:0010522", "CALOHA:TS-2024", "EFO:0000870", "EMAPA:18248", "FMA:7162", "MA:0002961", "MESH:D008208", "SCTID:362597000", "VHOG:0001761", "Wikipedia:Lymphatic_system" ; oboInOwl:hasExactSynonym "lymphatic system", "lymphatic tree system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymporeticular system" ; oboInOwl:id "UBERON:0006558" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "lymphatic part of lymphoid system" ; rdfs:subClassOf obo:UBERON_0011216, _:genid143801, _:genid143803 . obo:UBERON_0006561 obo:IAO_0000115 "An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels.." ; oboInOwl:hasDbXref "FMA:74623" ; oboInOwl:hasExactSynonym "non-lymphatic lymphoid system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006561" ; a owl:Class ; rdfs:label "non-lymphatic part of lymphoid system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002465 ] . obo:UBERON_0006562 obo:IAO_0000115 "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." ; obo:IAO_0000232 "currently this is an extremely generic class, encompassing both protostomes and deuterostomes." ; obo:IAO_0006012 "2023-04-20" ; obo:UBPROP_0000007 "branchial", "pharyngeal" ; oboInOwl:hasDbXref "FBbt:00005380", "MAT:0000049", "MESH:D010614", "MIAA:0000049" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior part of foregut", "pharyngeal tube" ; oboInOwl:id "UBERON:0006562" ; oboInOwl:inSubset core:grouping_class, core:uberon_slim ; a owl:Class ; rdfs:label "pharynx" ; rdfs:subClassOf obo:UBERON_0004921 . obo:UBERON_0006563 obo:IAO_0000115 "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]." ; oboInOwl:hasDbXref "FMA:85030" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006563" ; a owl:Class ; rdfs:label "tunica media of pulmonary trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002522 _:genid142288 ) ] . obo:UBERON_0006565 obo:IAO_0000115 "A urethral meatus that is part of a female urethra[Automatically generated definition]." ; obo:UBPROP_0000001 "The external urethral orifice (urinary meatus) is the external opening of the urethra, from which urine is ejected during urination. It is placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina; it usually assumes the form of a short, sagittal cleft with slightly raised margins. To its left and right are the openings of the Skene's ducts." ; oboInOwl:hasDbXref "EMAPA:36453", "FMA:85266", "MA:0002639", "SCTID:279479008", "Wikipedia:External_urethral_orifice_(female)" ; oboInOwl:hasExactSynonym "external orifice of female urethra", "external urethral orifice (female)", "female urethral meatus", "ostium urethrae externum (urethra feminina)", "urethral meatus of clitoral urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal urethral opening of female", "urethral opening of clitoral urethra" ; oboInOwl:id "UBERON:0006565" ; a owl:Class ; rdfs:label "female urethral meatus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012240 _:genid142293 ) ] . obo:UBERON_0006566 obo:IAO_0000115 "A myocardium that is part of a left ventricle of a heart." ; obo:UBPROP_0000001 "Myocardium of ventricle which is continuous with the tunica media of aorta." ; oboInOwl:hasDbXref "EMAPA:17339", "FMA:9558", "MA:0002983", "SCTID:362021000" ; oboInOwl:hasExactSynonym "left ventricular myocardium", "myocardium of left ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006566" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left ventricle myocardium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0003618 ] ; owl:equivalentClass _:genid142305 . obo:UBERON_0006567 obo:IAO_0000115 "A myocardium that is part of a right ventricle of a heart." ; obo:UBPROP_0000001 "Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk." ; oboInOwl:hasDbXref "EMAPA:17342", "FMA:9535", "MA:0002984", "SCTID:362020004" ; oboInOwl:hasExactSynonym "myocardium of right ventricle", "right ventricular myocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006567" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "right ventricle myocardium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0006563 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0006568 obo:IAO_0000115 "A nucleus of brain that is part of a hypothalamus." ; oboInOwl:hasDbXref "BTO:0002449", "EMAPA:35417", "FMA:258762", "MA:0002426", "SCTID:279304003" ; oboInOwl:hasExactSynonym "nucleus of hypothalamus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006568" ; a owl:Class ; rdfs:label "hypothalamic nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001898 ] ) ] . obo:UBERON_0006569 obo:IAO_0000115 "A nucleus of brain that is part of a diencephalon." ; oboInOwl:hasDbXref "TAO:0002191", "ZFA:0001659" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006569" ; a owl:Class ; rdfs:label "diencephalic nucleus" ; owl:equivalentClass _:genid142329 . obo:UBERON_0006574 obo:IAO_0000115 "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." ; obo:UBPROP_0000012 "FMA also has FMA:29321 but it's not clear how this differs" ; oboInOwl:hasDbXref "EMAPA:19159", "FMA:75383", "NCIT:C34245", "SCTID:245445008", "UMLS:C0821671", "Wikipedia:Pectinate_line" ; oboInOwl:hasExactSynonym "linea pectinata canalis analis", "pectinate line of anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Hilton's 'white line'", "dentate line", "linea anocutanea", "recto-anal junction", "site of anal membrane" ; oboInOwl:id "UBERON:0006574" ; a owl:Class ; rdfs:label "pectinate line" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ; owl:equivalentClass _:genid142334 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png"^^xsd:anyURI . obo:UBERON_0006585 obo:IAO_0000115 "An organ that is part of a vestibular system." ; oboInOwl:hasDbXref "BIRNLEX:2519", "UMLS:C0682674" ; oboInOwl:hasExactSynonym "balance organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006585" ; a owl:Class ; rdfs:label "vestibular organ" ; rdfs:subClassOf _:genid143884 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004681 ] ) ] . obo:UBERON_0006589 obo:IAO_0000115 "The round ligament of the uterus originates at the uterine horns, in the parametrium. It leaves the pelvis via the deep inguinal ring, passes through the inguinal canal and continues on to the labia majora where its fibers spread and mix with the tissue of the mons pubis[WP]. A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus[MESH]." ; oboInOwl:hasBroadSynonym "round ligament" ; oboInOwl:hasDbXref "FMA:20420", "GAID:130", "MESH:D012404", "NCIT:C34009", "SCTID:245495009", "UMLS:C0035877", "Wikipedia:Round_ligament_of_uterus" ; oboInOwl:hasExactSynonym "Hunter's ligament", "ligamentum teres of uterus", "ligamentum teres uteri", "round ligament of the uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ligamentum teres uteri" ; oboInOwl:id "UBERON:0006589" ; a owl:Class ; rdfs:label "round ligament of uterus" ; rdfs:subClassOf obo:UBERON_0008845, _:genid143890 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1138.png"^^xsd:anyURI . obo:UBERON_0006595 obo:IAO_0000115 "Presumptive structure of the blastula that will develop into endoderm." ; oboInOwl:hasDbXref "AAO:0000471", "EFO:0003437", "TAO:0000416", "ZFA:0000416" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006595" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive endoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0006596 oboInOwl:hasDbXref "AAO:0000468", "EFO:0003439", "TAO:0000568", "ZFA:0000568" ; oboInOwl:hasExactSynonym "future blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006596" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive blood" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000178 ] ) ] . obo:UBERON_0006598 obo:IAO_0000115 "Portion of embryonic tissue determined by fate mapping to become a structure." ; obo:IAO_0000116 "Consider merging with anlage" ; oboInOwl:hasDbXref "AAO:0000479", "TAO:0001116", "ZFA:0001116" ; oboInOwl:hasExactSynonym "future structure", "presumptive structures" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006598" ; a owl:Class ; rdfs:label "presumptive structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000061 ] ) ] . obo:UBERON_0006600 oboInOwl:hasDbXref "AAO:0000472", "EFO:0003462", "TAO:0001334", "ZFA:0001334" ; oboInOwl:hasExactSynonym "future enteric nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006600" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive enteric nervous system" ; rdfs:subClassOf _:genid143922 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:UBERON_0006601 obo:IAO_0000115 "Presumptive structure of the blastula that will develop into ectoderm." ; oboInOwl:hasDbXref "AAO:0000470", "EFO:0003466", "TAO:0001376", "XAO:0004132", "ZFA:0001376" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presumptive epidermis" ; oboInOwl:id "UBERON:0006601" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000307 ] _:genid142396 ) ] . obo:UBERON_0006603 obo:IAO_0000115 "Presumptive structure of the blastula that will develop into mesoderm." ; oboInOwl:hasDbXref "AAO:0000476", "EFO:0003467", "TAO:0001377", "ZFA:0001377" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006603" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive mesoderm" ; rdfs:subClassOf obo:UBERON_0006598 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ] . obo:UBERON_0006606 obo:IAO_0000115 "A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified]." ; obo:IAO_0000116 "this is placed as part of lower jaw region, as in this ontology the skeleton does not include joints" ; obo:UBPROP_0000001 "Joint that articulates the left and right dentary bones. Mandibular symphysis is unpaired.[TAO]" ; obo:UBPROP_0000008 "in snakes, the mandibular symphysis is composed of soft tissues, allowing independent movement of each mandible" ; oboInOwl:hasDbXref "AAO:0000277", "FMA:75779", "MA:0001490", "TAO:0001851", "Wikipedia:Symphysis_menti", "ZFA:0005488" ; oboInOwl:hasExactSynonym "dentary symphysis", "inter-dentary joint", "inter-mandibular joint", "symphysis menti" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mental symphysis", "symphysis mandibulae" ; oboInOwl:id "UBERON:0006606" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mandibular symphysis" ; rdfs:subClassOf obo:UBERON_0002216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ], _:genid143945 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002213 [ a owl:Restriction ; owl:onClass obo:UBERON_0004742 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png"^^xsd:anyURI . obo:UBERON_0006608 obo:IAO_0000115 "The corpus cavernosum clitoridis is one of a pair of sponge-like regions of erectile tissue which contain most of the blood in the clitoris during clitoral erection. This is homologous to the corpus cavernosum penis in the male; the body of the clitoris contains erectile tissue in a pair of corpora cavernosa (literally 'cave-like bodies'), with a recognisably similar structure." ; oboInOwl:hasDbXref "BTO:0002018", "FMA:20172", "SCTID:16657007", "Wikipedia:Corpus_cavernosum_of_clitoris" ; oboInOwl:hasExactSynonym "corpus cavernosum of clitoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavernous body of clitoris", "clitoral corpus cavernosum", "corpus cavernosum", "corpus cavernosum clitoridis" ; oboInOwl:id "UBERON:0006608" ; a owl:Class ; rdfs:label "corpus cavernosum clitoridis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006609 _:genid142425 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Clitoris_inner_anatomy.gif"^^xsd:anyURI . obo:UBERON_0006609 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "BTO:0005454", "FMA:321004", "Wikipedia:Corpus_cavernosum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006609" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "corpus cavernosum" ; rdfs:subClassOf obo:UBERON_0008324 . obo:UBERON_0006614 obo:IAO_0000115 "A sheet of extracellular matrix." ; obo:UBPROP_0000001 "Aponeuroses are layers of flat broad tendons. They have a shiny, whitish-silvery color, and are histologically similar to tendons, but are very sparingly supplied with blood vessels and nerves. When dissected, aponeuroses are papery, and peel off by sections. The primary regions with thick aponeurosis is in the ventral abdominal region, the dorsal lumbar region, and in the palmar region. Their primary function is to join muscles and the body parts the muscles act upon[Wikipedia:Aponeurosis]." ; obo:UBPROP_0000012 "in ZFA, aponeuroses are subtypes of tendons, but this is inconsistent with tendons being muscle-bone connections" ; oboInOwl:hasDbXref "AEO:0000092", "EHDAA2:0003092", "FMA:9722", "MESH:D000070606", "NCIT:C32133", "SCTID:331712004", "UMLS:C0225205", "Wikipedia:Aponeurosis", "ZFA:0005652" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aponeuroses", "aponeurotic" ; oboInOwl:id "UBERON:0006614" ; a owl:Class ; rdfs:label "aponeurosis" ; rdfs:subClassOf obo:UBERON_0000158, _:genid143968, _:genid143970, _:genid143972 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Aponeurosis.png"^^xsd:anyURI . obo:UBERON_0006615 obo:IAO_0000115 "A large vein or channel for the circulation of venous blood." ; obo:IAO_0000116 "check if it is valid to group ZFA class here." ; oboInOwl:hasDbXref "MA:0000070", "NCIT:C12877", "SCTID:341586007", "UMLS:C0226504", "ZFA:0007072" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blood sinus" ; oboInOwl:id "UBERON:0006615" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "venous sinus" ; rdfs:subClassOf obo:UBERON_0003920 . obo:UBERON_0006616 obo:IAO_0000115 "An external ear that is in the right side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "right auricular region" ; oboInOwl:hasDbXref "EMAPA:37361", "FMA:53643", "SCTID:368567003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006616" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right external ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001691 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0006617 obo:IAO_0000115 "An external ear that is in the left side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "left auricular region" ; oboInOwl:hasDbXref "EMAPA:37360", "FMA:53644", "SCTID:368589004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006617" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left external ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001691 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0006632 obo:IAO_0000115 "An artery with its origin in the lateral terminal branch of the internal thoracic artery, with distribution to the diaphragm and the intercostal muscles, and with anastomoses to the branches of the pericardiacophrenic and inferior phrenic." ; oboInOwl:hasDbXref "EMAPA:19215", "FMA:10645", "SCTID:244242003", "Wikipedia:Musculophrenic_artery" ; oboInOwl:hasExactSynonym "musculophrenic artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006632" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "musculo-phrenic artery" ; rdfs:subClassOf obo:UBERON_0004573 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002456 ] ) ] . obo:UBERON_0006633 obo:IAO_0000115 "A process of the scapula in most mammals representing the remnant of the coracoid bone of lower vertebrates thas has become fused with the scapula." ; obo:UBPROP_0000001 "The coracoid process is a small hook-like structure on the lateral edge of the superior anterior portion of the scapula. Pointing laterally forward, it, together with the acromion, serves to stabilize the shoulder joint. It is palpable in the deltopectoral groove between the deltoid and pectoralis major muscles. It is the site of attachment for several structures: * The pectoralis minor muscle - to 3rd to 5th ribs. * The short head of biceps brachii muscle - to Radial tuberosity. * The coracobrachialis muscle - to medial humerus. * The coracoclavicular ligament - to the clavicle. (The ligament is formed by the conoid ligament and trapezoid ligament.) * The coracoacromial ligament - to the acromion[WP][Wikipedia:Coracoid_process]." ; obo:UBPROP_0000008 "In humans is situated on its superior border and serves for the attachment of various muscles" ; oboInOwl:hasDbXref "EMAPA:25121", "FMA:13455", "SCTID:181912007", "Wikipedia:Coracoid_process" ; oboInOwl:hasExactSynonym "coracoid process", "coracoid process of the scapula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "processus coracoideus" ; oboInOwl:id "UBERON:0006633" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "coracoid process of scapula" ; rdfs:subClassOf obo:UBERON_0005913, _:genid144006 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Gray205_left_scapula_lateral_view.png"^^xsd:anyURI . obo:UBERON_0006635 obo:IAO_0000115 "The abdominal wall represents the boundaries of the abdominal cavity. The abdominal wall is split into the posterior (back), lateral (sides) and anterior (front) walls. There is a common set of layers covering and forming all the walls: the deepest being the extraperitoneal fat, the parietal peritoneum, and a layer of fascia which has different names over where it covers (eg transversalis, psoas fascia). Superficial to these, but not present in the posterior wall are the three layers of muscle, the transversus abdominis (transverse abdominal muscle), the internal (obliquus internus) and the external oblique (obliquus externus)." ; oboInOwl:hasDbXref "EHDAA:5976", "EMAPA:17744", "FMA:14627", "SCTID:362696003", "VHOG:0000764", "Wikipedia:Abdominal_wall" ; oboInOwl:hasExactSynonym "ventral abdominal wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006635" ; a owl:Class ; rdfs:label "anterior abdominal wall" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 ] . obo:UBERON_0006642 obo:IAO_0000115 "A muscle layer that is part of a fallopian tube." ; oboInOwl:hasDbXref "EMAPA:29046", "FMA:18318", "SCTID:259488000" ; oboInOwl:hasExactSynonym "muscle layer of fallopian tube", "muscle layer of oviduct", "muscle layer of uterine tube", "muscular coat of uterine tube", "muscular layer of uterine tube", "muscularis of uterine tube", "tunica muscularis (Tuba uterina)", "tunica muscularis tubae uterinae", "uterine tubal muscularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006642" ; a owl:Class ; rdfs:label "muscle layer of oviduct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_0006645 obo:IAO_0000115 "An adventitia that is part of a epididymis." ; oboInOwl:hasDbXref "EMAPA:30443", "FMA:19136" ; oboInOwl:hasExactSynonym "epididymis adventitia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006645" ; a owl:Class ; rdfs:label "adventitia of epididymis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:UBERON_0006646 obo:IAO_0000115 "A muscle layer that is part of a epididymis." ; oboInOwl:hasDbXref "EMAPA:30747", "FMA:19149" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006646" ; a owl:Class ; rdfs:label "muscle layer of epididymis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:UBERON_0006647 obo:IAO_0000115 "An adventitia that is part of a vas deferens." ; oboInOwl:hasDbXref "EMAPA:29767", "FMA:19238", "SCTID:299803005" ; oboInOwl:hasExactSynonym "adventitia of deferent duct", "adventitia of ductus deferens", "adventitia of vas deferens", "deferent ductal adventitia", "tunica adventitia (ductus deferens)", "tunica adventitia ductus deferentis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006647" ; a owl:Class ; rdfs:label "adventitia of ductus deferens" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ] . obo:UBERON_0006648 obo:IAO_0000115 "An adventitia that is part of a seminal vesicle." ; oboInOwl:hasDbXref "EMAPA:29775", "FMA:19403", "SCTID:252406002" ; oboInOwl:hasExactSynonym "adventitia of seminal gland", "seminal vesicle adventitia", "tunica adventitia (vesicula seminalis)", "tunica adventitia glandulae vesiculosae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006648" ; a owl:Class ; rdfs:label "adventitia of seminal vesicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:UBERON_0006652 oboInOwl:hasDbXref "EMAPA:30997", "FMA:19976", "SCTID:253069005" ; oboInOwl:hasExactSynonym "muscular coat of vagina", "tunica muscularis vaginae", "vaginal muscularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006652" ; a owl:Class ; rdfs:label "muscular layer of vagina" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0006653 obo:IAO_0000115 "Erectile tissue at the end of the clitoris, which is continuous with the intermediate part of the vestibulovaginal bulbs[BTO]. The clitoral glans (glans clitoridis) is an external portion of the clitoris[WP]." ; oboInOwl:hasDbXref "BTO:0003117", "EMAPA:19170", "EMAPA:30829", "FMA:19999", "NCIT:C32681", "SCTID:362241002", "UMLS:C0227769", "Wikipedia:Clitoral_glans" ; oboInOwl:hasExactSynonym "clitoris glans", "glans of clitoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glans clitoridis", "glans clitoris" ; oboInOwl:id "UBERON:0006653" ; a owl:Class ; rdfs:label "glans clitoris" ; rdfs:subClassOf obo:UBERON_0008324, _:genid144070 ; owl:equivalentClass _:genid142529 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Clitoris_inner_anatomy.gif"^^xsd:anyURI . obo:UBERON_0006655 obo:IAO_0000115 "An incomplete wall of connective tissue and nonstriated muscle (dartos fascia) dividing the scrotum into two sacs, each containing a testis." ; oboInOwl:hasDbXref "EMAPA:29745", "FMA:20729", "SCTID:279591002" ; oboInOwl:hasExactSynonym "scrotal septum", "septum scroti" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006655" ; a owl:Class ; rdfs:label "septum of scrotum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002384 ], _:genid142548 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0035105 ] ) ] . obo:UBERON_0006657 obo:IAO_0000115 "Anatomical cavity for the proximal articular surface of the proximal limb or fin element with the scapulocoracoid or equivalent structure." ; obo:UBPROP_0000001 "Cavity for the articulation of the forelimb formed by the scapula, coracoid, and clavicle.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of scapular area (AAO:0000935)[AAO]" ; obo:UBPROP_0000008 "The glenoid fossa can be associated with the metapterygium in sarcopterygians, or either the meso- or propterygium in basal gnathostomes such as Chondrichthyans" ; obo:UBPROP_0000012 "FMA also has classes for the bony parts around the cavity - these may be more useful than the cavity term itself" ; oboInOwl:hasDbXref "AAO:0000749", "EMAPA:25122", "FMA:23275", "NCIT:C32682", "SCTID:181914008", "UMLS:C1261046", "Wikipedia:Glenoid_cavity" ; oboInOwl:hasExactSynonym "cavitas glenoidalis scapulae", "cavitus glenoidalis", "glenoid cavity", "glenoid cavity of scapula", "glenoid facet" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas glenoidalis", "glenoid cavity" ; oboInOwl:id "UBERON:0006657" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "glenoid fossa" ; rdfs:subClassOf obo:UBERON_0004704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004753 ], _:genid144091 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray328.png"^^xsd:anyURI . obo:UBERON_0006658 obo:IAO_0000115 "A joint that connects one phalanx to another along a proximodistal axis." ; obo:UBPROP_0000001 "Hinge joints between the phalanges of the hand or foot[ncithesaurus:Interphalangeal_Joint]." ; oboInOwl:hasDbXref "EMAPA:37884", "FMA:42765", "NCIT:C101527", "galen:InterphalangealJoint" ; oboInOwl:hasExactSynonym "inter-phalangeal joint", "inter-phalanx joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006658" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interphalangeal joint" ; rdfs:subClassOf obo:UBERON_0002217, _:genid144109, _:genid144111 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onClass obo:UBERON_0003221 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0006660 obo:IAO_0000115 "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." ; obo:IAO_0000116 "currently this class conflates a generic layer of muscle and a specific layer found lining the digestive tract (the muscularis externa), typically composed of circular and longitudinal layers (although this varies)" ; obo:RO_0002171 obo:UBERON_0000009, obo:UBERON_0006676 ; obo:UBPROP_0000001 "An outer layer of smooth muscle surrounding a hollow or tubular organ as the bladder, esophagus, large intestine, small intestine, stomach, ureter, uterus, and vagina that often consists of an inner layer of circular fibers serving to narrow the lumen of the organ and an outer layer of longitudinal fibers serving to shorten its length[BTO]." ; obo:UBPROP_0000008 "typically smooth muscle, but there may be exceptions - in the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle." ; oboInOwl:hasDbXref "BTO:0004838", "SCTID:86915006", "UMLS:C0225358", "Wikipedia:Muscular_layer" ; oboInOwl:hasExactSynonym "muscular layer", "muscularis layer", "tunica muscularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular coat", "muscularis", "muscularis externa", "muscularis propria", "transverse muscular fibers", "tunica externa", "tunica muscularis" ; oboInOwl:id "UBERON:0006660" ; a owl:Class ; rdfs:label "muscular coat" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002385 ] . obo:UBERON_0006661 obo:IAO_0000115 "The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance." ; oboInOwl:hasDbXref "EMAPA:19210", "FMA:46768", "SCTID:368677009", "Wikipedia:Galea_aponeurotica" ; oboInOwl:hasExactSynonym "aponeurosis epicranialis", "aponeurosis of epicranius", "epicranial aponeurosis", "epicranius aponeurosis", "galea aponeurotica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial aponeurosis", "epicranial aponeurosis", "galea aponeurosis", "galea aponeurotica; aponeurosis epicranialis", "galeal aponeurosis" ; oboInOwl:id "UBERON:0006661" ; a owl:Class ; rdfs:label "epicranial aponeurosis" ; rdfs:subClassOf obo:UBERON_0006614, _:genid144132 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png"^^xsd:anyURI . obo:UBERON_0006664 obo:IAO_0000115 "The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity." ; obo:IAO_0000116 "TODO - check for synonymy between greater and major; branching_part_of relation is made in FMA at level of descending GPA" ; oboInOwl:hasDbXref "EMAPA:18754", "FMA:49795", "MA:0001993", "SCTID:312163002", "Wikipedia:Greater_palatine_artery" ; oboInOwl:hasExactSynonym "major palatine artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria palatina major" ; oboInOwl:id "UBERON:0006664" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "greater palatine artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 ] . obo:UBERON_0006668 obo:IAO_0000115 "On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP]." ; oboInOwl:hasDbXref "EMAPA:18707", "FMA:55805", "Wikipedia:Carotid_canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis caroticus" ; oboInOwl:id "UBERON:0006668" ; a owl:Class ; rdfs:label "carotid canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001532 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Gray141.png"^^xsd:anyURI . obo:UBERON_0006671 obo:IAO_0000115 "A fat pad that is part of a orbital region." ; oboInOwl:hasDbXref "EMAPA:19152", "FMA:59005", "SCTID:363656009" ; oboInOwl:hasExactSynonym "intraorbital fat pad", "orbital fat", "orbital fat body", "retrobulbar fat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006671" ; a owl:Class ; rdfs:label "orbital fat pad" ; rdfs:subClassOf _:genid144160 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ) ] . obo:UBERON_0006673 obo:IAO_0000115 "A canal within the mandible that contains the inferior alveolar nerve, inferior alveolar artery, and inferior alveolar vein. It runs obliquely downward and forward in the ramus, and then horizontally forward in the body, where it is placed under the alveoli and communicates with them by small openings." ; obo:UBPROP_0000012 "TAO has mandibular sensory canal, which is part of the lateral line system" ; oboInOwl:hasDbXref "EMAPA:19161", "FMA:59473", "SCTID:368876003", "Wikipedia:Mandibular_canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inferior alveolar canal" ; oboInOwl:id "UBERON:0006673" ; a owl:Class ; rdfs:label "mandibular canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0014693 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005744 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0018405 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray1003.png"^^xsd:anyURI . obo:UBERON_0006674 obo:IAO_0000115 "An entrance or exit of the inguinal canal." ; oboInOwl:hasDbXref "EMAPA:29307", "FMA:65075", "SCTID:278830004", "Wikipedia:Inguinal_rings" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006674" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "inguinal ring" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003702 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006204 ] . obo:UBERON_0006675 obo:IAO_0000115 "A valve that is part of a vein." ; oboInOwl:hasDbXref "FMA:68095", "MESH:D055422" ; oboInOwl:hasExactSynonym "valve of vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006675" ; a owl:Class ; rdfs:label "venous valve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003978 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0006677 obo:IAO_0000115 "An anatomical boundary that adjacent_to a epithelium." ; oboInOwl:hasDbXref "FMA:70997" ; oboInOwl:hasExactSynonym "epithelium surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006677" ; a owl:Class ; rdfs:label "surface of epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000483 ] ) ] . obo:UBERON_0006682 obo:IAO_0000115 "The hypoglossal canal is a bony canal in the occipital bone of the skull." ; oboInOwl:hasDbXref "EMAPA:19012", "FMA:75370", "SCTID:139380001", "Wikipedia:Hypoglossal_canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior condylar canal", "canalis nervi hypoglossi", "hyperglossal canal" ; oboInOwl:id "UBERON:0006682" ; a owl:Class ; rdfs:label "hypoglossal canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001676 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001650 ] ) ] . obo:UBERON_0006683 obo:IAO_0000115 "A gap between bones in the skull at the junction of the sagittal suture and lambdoidal suture." ; obo:UBPROP_0000008 "In humans it generally closes in 6-8 weeks from birth. A delay in closure is associated with congential hypothyroidism" ; oboInOwl:hasDbXref "EMAPA:19200", "FMA:75440", "SCTID:244681005", "Wikipedia:Posterior_fontanelle" ; oboInOwl:hasExactSynonym "fonticulus posterior", "occipital fontanelle", "posterior fontanelle of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006683" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior fontanelle" ; rdfs:subClassOf obo:UBERON_0002221, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002491 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002492 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png"^^xsd:anyURI . obo:UBERON_0006686 obo:IAO_0000115 "A vein that is part of a vertebral column." ; oboInOwl:hasDbXref "EMAPA:18255", "FMA:76735", "MA:0002108", "SCTID:181376008", "Wikipedia:Spinal_veins" ; oboInOwl:hasExactSynonym "vena spinalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spinal branch" ; oboInOwl:id "UBERON:0006686" ; a owl:Class ; rdfs:label "spinal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] . obo:UBERON_0006689 obo:IAO_0000115 "A small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue." ; oboInOwl:hasBroadSynonym "frenulum" ; oboInOwl:hasDbXref "EMAPA:18656", "FMA:54659", "NCIT:C87076", "SCTID:264113009", "UMLS:C2339893", "Wikipedia:Frenulum_of_tongue" ; oboInOwl:hasExactSynonym "frenulum linguae", "frenulum linguæ", "frenulum of the tongue", "lingual frenulum", "tongue frenulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lingual frenum" ; oboInOwl:id "UBERON:0006689" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "frenulum of tongue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001723 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003679 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/13/Gray1202.png"^^xsd:anyURI . obo:UBERON_0006692 obo:IAO_0000115 "A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes." ; obo:IAO_0000116 "TODO - check neural vs vertebral canal; embryonic vs adult?" ; obo:UBPROP_0000001 "Canal formed by the vertebral centra ventrally, the pedicels laterally, and the neural arches dorsally that encloses and protects the spinal cord.[AAO]" ; oboInOwl:hasDbXref "AAO:0000693", "FMA:9680", "GAID:242", "NCIT:C33869", "NCIT:C34221", "SCTID:361746009", "UMLS:C0037922", "UMLS:C1522467", "Wikipedia:Spinal_canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "c. vertebralis", "foramen vertebrale", "neural canal", "spinal canal", "spinal cavity", "vertebral canal" ; oboInOwl:id "UBERON:0006692" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vertebral canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0002240 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002571 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png"^^xsd:anyURI . obo:UBERON_0006694 obo:IAO_0000115 "A vasculature that is part of a cerebellum." ; oboInOwl:hasDbXref "FMA:268519" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006694" ; a owl:Class ; rdfs:label "cerebellum vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0006715 obo:IAO_0000115 "Paired, long bones of endochondral origin formed by the fusion of the radius and ulna." ; oboInOwl:hasDbXref "AAO:0000901", "XAO:0003209" ; oboInOwl:hasExactSynonym "radioulna", "radius+ulna", "radius-ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006715" ; a owl:Class ; rdfs:label "radio-ulna" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010848 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001423 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001424 ], _:genid144254 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015002 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0006716 obo:IAO_0000115 "The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus)." ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group" ; oboInOwl:hasDbXref "Wikipedia:Carpus_and_tarsus_of_land_vertebrates" ; oboInOwl:hasExactSynonym "carpus/tarsus", "mesopodial limb segment", "mesopodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesopod" ; oboInOwl:id "UBERON:0006716" ; a owl:Class ; rdfs:label "mesopodium region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0009878 ], _:genid144268 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0009877 ] [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0002471 ] ) ] . obo:UBERON_0006717 obo:IAO_0000115 "The collection of all skeletal elements in an autopodium region." ; obo:UBPROP_0000001 "Distal section of the limb skeleton, consisting of the anterior autopodium or posterior autopodium.[VSAO]" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group" ; oboInOwl:hasDbXref "VSAO:0005019" ; oboInOwl:hasExactSynonym "autopod skeleton", "autopodial skeleton", "skeletal parts of autopod", "skeleton of autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "autopodium" ; oboInOwl:id "UBERON:0006717" ; a owl:Class ; rdfs:label "autopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004381 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0011584 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002470 ] ) ] . obo:UBERON_0006718 obo:IAO_0000115 "The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle." ; obo:UBPROP_0000001 "The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle.[FEED]" ; oboInOwl:hasDbXref "BTO:0005226", "EMAPA:25141", "FMA:49011", "MA:0002361", "MFMO:0000083", "NCIT:C32861", "SCTID:244771003", "UMLS:C1512882", "Wikipedia:Medial_pterygoid_muscle" ; oboInOwl:hasExactSynonym "musculus pterygoideus internus", "musculus pterygoideus medialis", "pterygoid medialis", "pterygoideus medial", "pterygoideus medialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal pterygoid", "internal pterygoid muscle", "medial pterygoid", "pterygoidei internus", "pterygoideus internus" ; oboInOwl:id "UBERON:0006718" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "medial pterygoid muscle" ; rdfs:subClassOf obo:UBERON_0006720, _:genid144287, _:genid144289, _:genid144291 ; owl:disjointWith obo:UBERON_0006719 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Musculuspterygoideusmedialis.png"^^xsd:anyURI . obo:UBERON_0006719 obo:IAO_0000115 "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and temporomandibular joint (TMJ) capsule, and the cranial base." ; obo:UBPROP_0000001 "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and TMJ capsule, and the cranial base.[FEED]" ; obo:UBPROP_0000014 "only masticatory muscle that depresses mandible (opens jaw)" ; oboInOwl:hasBroadSynonym "pterygoid lateralis" ; oboInOwl:hasDbXref "EMAPA:25140", "FMA:49015", "MA:0002360", "MFMO:0000074", "NCIT:C32570", "SCTID:244772005", "UMLS:C1517045", "Wikipedia:Lateral_pterygoid_muscle" ; oboInOwl:hasExactSynonym "external pterygoid muscle", "lateral pteregoid", "lateral pteregoid muscle", "lateral pterygoid", "m. pterygoideus externus", "m. pterygoideus lateralis", "musculus pterygoides lateralis", "musculus pterygoideus externus", "musculus pterygoideus lateralis", "pterygoideus externus", "pterygoideus externus muscle", "pterygoideus lateral", "pterygoideus lateral muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006719" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lateral pterygoid muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/539"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0006720, [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0013647 ], _:genid144312, _:genid144315, _:genid144317 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018544 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002517 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004657 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Musculuspterygoideuslateralis.png"^^xsd:anyURI . obo:UBERON_0006720 obo:UBPROP_0000008 "We use this class to group the medial and lateral pterygoids of mammals as well as the pterygoideus of amphibians and reptiles. Note that FEED includes a distinct class for the reptilian pterygoideus. In future, this branch of the ontology may be refined to include a more complete classification of jaw adductors across gnathostomes. See for example DOI:10.1134/S1062359010090050" ; oboInOwl:hasDbXref "AAO:0010730", "EMAPA:25139", "GAID:147", "MESH:D011626", "SCTID:244770002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pterygoid", "pterygoideus", "pterygoideus muscle" ; oboInOwl:id "UBERON:0006720" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "pterygoid muscle" ; rdfs:subClassOf obo:UBERON_0003681, _:genid144336, _:genid144338 . obo:UBERON_0006722 obo:IAO_0000115 "The handle of the malleus; the portion that extends downward, inward, and backward from the neck of the malleus; it is embedded throughout its length in the tympanic membrane." ; obo:UBPROP_0000008 "Conical in shape, with the cone extending inwards (e.g. mammals) or outwards (e.g. in birds)" ; oboInOwl:hasDbXref "FMA:52760", "MA:0002985", "SCTID:264091009" ; oboInOwl:hasExactSynonym "malleus handle", "manubrium of malleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "handle of malleus", "malleal manubrium", "malleus handle", "malleus manubrium", "manubrium mallei", "manubrium of malleus" ; oboInOwl:id "UBERON:0006722" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manubrium of malleus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001689 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001689 ], _:genid144342 . obo:UBERON_0006723 obo:IAO_0000115 "The central cone shaped core of spongy bone about which turns the spiral canal." ; oboInOwl:hasBroadSynonym "modiolus" ; oboInOwl:hasDbXref "BTO:0001693", "EMAPA:35575", "FMA:61278", "MA:0001182", "NCIT:C33135", "SCTID:361314007", "UMLS:C0229503", "Wikipedia:Modiolus_(cochlea)" ; oboInOwl:hasExactSynonym "cochlea modiolus", "modiolus cochleae", "modiolus of cochlea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columella cochleae" ; oboInOwl:id "UBERON:0006723" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "cochlear modiolus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001844 ], _:genid144355 ; owl:disjointWith obo:UBERON_0011386 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png"^^xsd:anyURI . obo:UBERON_0006726 obo:IAO_0000115 "A corner of the outer (lateral) part of an eye." ; obo:UBPROP_0000001 "The angle at the end of the palpebral fissure, the slit between the eyelids, close to the temporal region of the skull. [ISBN:0124020607, p.263][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000910", "EHDAA:9039", "EMAPA:37458", "FMA:59315", "MA:0001264", "NCIT:C49597", "SCTID:362525004", "UMLS:C1711189", "VHOG:0001571" ; oboInOwl:hasExactSynonym "lateral canthus of eye", "lateral palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral angle of eye", "lateral canthus", "outer canthi", "temporal canthus" ; oboInOwl:id "UBERON:0006726" ; a owl:Class ; rdfs:comment "see also FMA:59321" ; rdfs:label "outer canthus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006742 [ a owl:Restriction ; owl:onProperty core:in_outermost_side_of ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0006742 obo:IAO_0000115 "A canthus is a corner of the eye where the upper and lower eyelids meet. The bicanthal plane is the transversal plane linking both canthi and defines the upper boundary of the midface." ; obo:UBPROP_0000007 "canthal" ; oboInOwl:hasDbXref "EMAPA:37457", "FMA:59222", "SCTID:181145006", "Wikipedia:Canthus" ; oboInOwl:hasExactSynonym "palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "angle of eye", "bicanthal", "bicanthal plane", "canthi", "canthoplasty", "canthorum", "canthus (anatomy)", "canthus of eye" ; oboInOwl:id "UBERON:0006742" ; a owl:Class ; rdfs:label "canthus" ; rdfs:subClassOf obo:UBERON_0007651, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001712 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001713 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray892.png"^^xsd:anyURI . obo:UBERON_0006756 obo:IAO_0000115 "During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's]." ; obo:UBPROP_0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0001081", "EMAPA:17187", "FMA:312476", "SCTID:308821003", "VHOG:0000730", "Wikipedia:Tuberculum_impar" ; oboInOwl:hasExactSynonym "median lingual swelling", "median tongue bud", "tuberculum impar", "tuberculum linguale mediale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006756" ; a owl:Class ; rdfs:comment "The thyroid initially develops caudal to the tuberculum impar . This embryonic swelling arises from the first pharyngeal arch and occurs midline on the floor of the developing pharynx, eventually helping form the tongue as the 2 lateral lingual swellings overgrow it. [http://emedicine.medscape.com/article/845125-overview]" ; rdfs:label "median lingual swelling" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ], _:genid144394 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png"^^xsd:anyURI . obo:UBERON_0006757 obo:IAO_0000115 "During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line." ; obo:UBPROP_0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" ; obo:UBPROP_0000010 "paired" ; oboInOwl:hasDbXref "EHDAA2:0000911", "EMAPA:17189", "FMA:313628", "VHOG:0000731", "Wikipedia:Lateral_lingual_swelling" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral lingual prominence", "lateral swellings", "tuberculum laterale", "tuberculum linguale laterale" ; oboInOwl:id "UBERON:0006757" ; a owl:Class ; rdfs:label "lateral lingual swelling" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006260 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png"^^xsd:anyURI . obo:UBERON_0006761 obo:IAO_0000115 "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm." ; oboInOwl:hasDbXref "EFO:0001403", "EMAPA:37835", "FMA:58342", "GAID:896", "MESH:D016850", "SCTID:63716004", "Wikipedia:Corneal_limbus", "ZFA:0005570" ; oboInOwl:hasExactSynonym "cornea limbus", "corneal limbus", "corneal-scleral limbus", "corneoscleral junction", "limbus corneae", "sclerocorneal junction", "sclerocorneal limbus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "limbus corneae" ; oboInOwl:id "UBERON:0006761" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:comment "This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343" ; rdfs:label "corneo-scleral junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000964 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png"^^xsd:anyURI . obo:UBERON_0006762 obo:IAO_0000115 "The zonule of Zinn (Zinn's membrane, ciliary zonule) is a ring of fibrous strands connecting the ciliary body with the crystalline lens of the eye. The zonule of Zinn is split into two layers: a thin layer, which lines the hyaloid fossa, and a thicker layer, which is a collection of zonular fibers. Together, the fibers are known as the suspensory ligament of the lens[WP]. Modified or toughened vitreous that suspend the lens at the equator to the non-pigmented epithelium of the ciliary zone. In zebrafish, dorsal zonules are thickened as compared to ventral zonules. In both dorsal and ventral regions, these fibers delimit the vitreous body aqueous humor boundary[ZFA]." ; oboInOwl:hasDbXref "FMA:58838", "SCTID:362524000", "Wikipedia:Zonule_of_Zinn", "ZFA:0005573" ; oboInOwl:hasExactSynonym "Zinn's membrane", "ciliary zonule", "zonule of Zinn", "zonules" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ciliary zonule", "suspensory ligament of the lens", "zonula", "zonula ciliaris", "zonular fiber", "zonule" ; oboInOwl:id "UBERON:0006762" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "suspensory ligament of lens" ; rdfs:subClassOf obo:UBERON_0008841, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000965 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001775 ], _:genid144427, _:genid144431 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg"^^xsd:anyURI . obo:UBERON_0006763 obo:IAO_0000115 "Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue." ; oboInOwl:hasDbXref "BTO:0005131", "EFO:0001916", "FMA:62131", "NCIT:C32365", "UMLS:C1179037" ; oboInOwl:hasExactSynonym "conjunctiva epithelium", "conjunctival epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006763" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "epithelium of conjunctiva" ; rdfs:subClassOf obo:UBERON_0010304, _:genid144449 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:UBERON_0006767 obo:IAO_0000115 "The hemispheric articular surface at the upper extremity of the thigh bone[Stedman, 26th ed]. The femur head is the highest part of the thigh bone. It is supported by the neck of the femur. The head is globular and forms rather more than a hemisphere, is directed upward, medialward, and a little forward, the greater part of its convexity being above and in front. Its surface is smooth, coated with cartilage in the fresh state, except over an ovoid depression, the fovea capitis femoris, which is situated a little below and behind the center of the head, and gives attachment to the ligament of head of femur. If there is a fracture of the neck of the femur, the blood supply through the ligament becomes crucial. In orthopedic surgery, the head of the femur is important because it can undergo avascular necrosis and consequent osteochondritis dissecans. The head is removed in total hip replacement surgery [WP]." ; obo:UBPROP_0000001 "Proximal head of the femur, which articulates with the acetabulum.[AAO]" ; oboInOwl:hasDbXref "AAO:0000892", "EMAPA:37541", "FMA:32851", "MA:0003050", "MESH:D005270", "NCIT:C32718", "SCTID:361791000", "UMLS:C0015813", "Wikipedia:Femur_head", "galen:FemoralHead" ; oboInOwl:hasExactSynonym "acetabular head", "femoral head", "kopf des Schenkelbeins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "capital femoral epiphysis", "caput femoris", "femur head" ; oboInOwl:id "UBERON:0006767" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "head of femur" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004412 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001269 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png"^^xsd:anyURI . obo:UBERON_0006799 obo:IAO_0000115 "An epithelium that is composed primarily of secretory cells." ; obo:IAO_0000116 "consider splitting epithelium from epithelial tissue" ; oboInOwl:hasDbXref "BTO:0002991", "NCIT:C43370", "NCIT:C45715", "UMLS:C0682578", "UMLS:C1708242" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006799" ; a owl:Class ; rdfs:label "glandular epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000150 ] ) ] . obo:UBERON_0006800 obo:IAO_0000115 "Non-material anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010267", "AEO:0000008", "BILA:0000008", "CARO:0000008", "EHDAA2:0003008", "FMA:9657", "HAO:0000008", "TAO:0001837", "TGMA:0001828", "XAO:0004003", "ZFA:0001689" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006800" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical line" ; rdfs:subClassOf obo:UBERON_0000015 . obo:UBERON_0006801 obo:IAO_0000115 "Hemispherical structure on proximal epiphysis of humerus that articulates with glenoid cavity[WP,modified]." ; obo:UBPROP_0000001 "Hemispherical ball on the proximal end of the humerus that fits into the glenoid cavity of the pectoral girdle to form the shoulder joint[AAO]." ; oboInOwl:hasAlternativeId "UBERON:3000835" ; oboInOwl:hasDbXref "AAO:0000835", "EMAPA:25050", "FMA:13304", "NCIT:C32720", "SCTID:181924000", "UMLS:C0223683", "Wikipedia:Upper_extremity_of_humerus#Humeral_head", "galen:HeadOfHumerus" ; oboInOwl:hasExactSynonym "head of humerus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caput humeri", "humeral head" ; oboInOwl:id "UBERON:0006801" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal head of humerus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004411 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001470 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0006657 ] . obo:UBERON_0006805 obo:IAO_0000115 "Medial end of the clavicle, which usually lies on the ventral side of the epicoracoid cartilage, just posterior to the epicoracoid bridge." ; oboInOwl:hasDbXref "AAO:0000812", "FMA:23297", "SCTID:181920009" ; oboInOwl:hasExactSynonym "extremitas sternalis (clavicula)", "extremitas sternalis claviculae", "medial end of clavicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extremitas medialis", "medial end", "proximal epyphysis of clavicle" ; oboInOwl:id "UBERON:0006805" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sternal end of clavicle" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001105 ] . obo:UBERON_0006810 obo:IAO_0000115 "The olecranon is a large, thick, curved bony eminence of the forearm that projects behind the elbow. It is situated at the upper (proximal) end of the ulna, one of the two bones in the forearm. When the hand faces forward the olecranon faces towards the back (posteriorly). It is bent forward at the summit so as to present a prominent lip which is received into the olecranon fossa of the humerus in extension of the forearm. Its base is contracted where it joins the body and the narrowest part of the upper end of the ulna. Its posterior surface, directed backward, is triangular, smooth, subcutaneous, and covered by a bursa. Its superior surface is of quadrilateral form, marked behind by a rough impression for the insertion of the Triceps brachii; and in front, near the margin, by a slight transverse groove for the attachment of part of the posterior ligament of the elbow-joint. Its anterior surface is smooth, concave, and forms the upper part of the semilunar notch. Its borders present continuations of the groove on the margin of the superior surface; they serve for the attachment of ligaments, viz. , the back part of the ulnar collateral ligament medially, and the posterior ligament laterally. From the medial border a part of the Flexor carpi ulnaris arises; while to the lateral border the anconeus muscle is attached." ; obo:IAO_0000116 "check AAO" ; obo:UBPROP_0000001 "Large and thick process situated at the proximal (upper) end of the ulna. Its inner face forms the medial articular surface that articulates with the humeral head.[AAO]" ; oboInOwl:hasDbXref "AAO:0000843", "FMA:39795", "NCIT:C33200", "SCTID:181949001", "UMLS:C0223710", "Wikipedia:Olecranon" ; oboInOwl:hasExactSynonym "olecranon process of ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "olecranon process", "ulnar process" ; oboInOwl:id "UBERON:0006810" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "olecranon" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006822 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/60/Gray212.png"^^xsd:anyURI . obo:UBERON_0006812 obo:IAO_0000115 "The mental foramen is one of two holes ('foramina') located on the anterior surface of the mandible. It permits passage of the mental nerve and vessels. The mental foramen descends slightly in edentulous individuals." ; oboInOwl:hasDbXref "AAO:0000298", "FMA:53171", "MESH:D000080383", "SCTID:244686000", "Wikipedia:Mental_foramen" ; oboInOwl:hasExactSynonym "mental foramina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramen mentale", "foramen mentalis" ; oboInOwl:id "UBERON:0006812" ; a owl:Class ; rdfs:label "mental foramen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001684 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001617 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0018406 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png"^^xsd:anyURI . obo:UBERON_0006813 obo:IAO_0000115 "Structural framework that provides support to the nasal sacs and ducts." ; oboInOwl:hasDbXref "AAO:0000320", "FMA:60116", "SCTID:281486007" ; oboInOwl:hasExactSynonym "skeleton of nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006813" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasal skeleton" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid144514, _:genid144516 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] . obo:UBERON_0006815 obo:IAO_0000115 "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." ; obo:UBPROP_0000001 "Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" ; obo:UBPROP_0000009 "cushions body organs" ; oboInOwl:hasDbXref "AAO:0000027", "FMA:63897", "SCTID:68477002" ; oboInOwl:hasExactSynonym "loose areolar connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "areolar tissue", "loose connective tissue" ; oboInOwl:id "UBERON:0006815" ; a owl:Class ; rdfs:label "areolar connective tissue" ; rdfs:subClassOf obo:UBERON_0011825, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000030 ], [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0000062 ], _:genid144523 . obo:UBERON_0006822 obo:IAO_0000115 "The head of ulna presents an articular surface, part of which, of an oval or semilunar form, is directed downward, and articulates with the upper surface of the triangular articular disk which separates it from the wrist-joint; the remaining portion, directed lateralward, is narrow, convex, and received into the ulnar notch of the radius." ; oboInOwl:hasDbXref "FMA:33751", "SCTID:304590006", "Wikipedia:Head_of_ulna", "galen:HeadOfUlna" ; oboInOwl:hasExactSynonym "caput ulnae", "head of ulna", "proximal end of ulna", "upper end of ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caput ulnae" ; oboInOwl:id "UBERON:0006822" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of ulna" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0006833 obo:IAO_0000115 "An anatomical space that surrounded_by a trachea." ; oboInOwl:hasDbXref "FMA:7469", "SCTID:197486000" ; oboInOwl:hasExactSynonym "lumen of cartilaginous trachea", "tracheal lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006833" ; a owl:Class ; rdfs:label "lumen of trachea" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0006834 obo:IAO_0000115 "A subdivision of a the reproductive tract in a female organism that is the site of embryo development." ; oboInOwl:hasBroadSynonym "uterus" ; oboInOwl:hasDbXref "TADS:0000421", "WBbt:0006760" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006834" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "uterus or analog" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0009790 ] ) ] . obo:UBERON_0006838 obo:IAO_0000115 "Branch of spinal nerve that innervates the hypaxial muscles." ; oboInOwl:hasBroadSynonym "ramus anterior", "ventral ramus" ; oboInOwl:hasDbXref "FMA:5982", "Wikipedia:Anterior_ramus_of_spinal_nerve" ; oboInOwl:hasExactSynonym "anterior primary ramus of spinal nerve", "anterior ramus of spinal nerve", "ventral ramus of spinal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior branch of spinal nerve", "ramus anterior nervi spinalis" ; oboInOwl:id "UBERON:0006838" ; a owl:Class ; rdfs:label "ventral ramus of spinal nerve" ; owl:disjointWith obo:UBERON_0006839 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008777 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0005476 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg"^^xsd:anyURI . obo:UBERON_0006839 obo:IAO_0000115 "Branch of spinal nerve that innervates the epaxial muscles." ; oboInOwl:hasBroadSynonym "dorsal ramus", "ramus posterior" ; oboInOwl:hasDbXref "FMA:5983", "Wikipedia:Posterior_ramus_of_spinal_nerve" ; oboInOwl:hasExactSynonym "posterior primary ramus", "posterior ramus of spinal nerve", "ramus posterior nervi spinalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior branch of spinal nerve" ; oboInOwl:id "UBERON:0006839" ; a owl:Class ; rdfs:label "dorsal ramus of spinal nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008778 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0005476 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png"^^xsd:anyURI . obo:UBERON_0006841 obo:IAO_0000115 "Vein that is central to a lobule in the liver." ; oboInOwl:hasBroadSynonym "central vein" ; oboInOwl:hasDbXref "FMA:17544", "NCIT:C32281", "SCTID:272023004", "TAO:0005168", "Wikipedia:Central_veins_of_liver", "ZFA:0005168" ; oboInOwl:hasExactSynonym "terminal branch of hepatic vein", "terminal hepatic venule", "vena centralis (hepar)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006841" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "central vein of liver" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004647 ] . obo:UBERON_0006844 obo:IAO_0000115 "A raised area of the biting surface of a tooth." ; obo:IAO_0000232 "this class may be obsoleted and split - the TAO class is generic, the mammalian class refers specifically to a molariform tooth" ; obo:UBPROP_0000001 "Anatomical structure that is a natural outgrowth, prominence, or point that is part of the surface of a tooth.[TAO]", "the elevated, somewhat pointed portions of the chewing surfaces on premolar and molar teeth" ; oboInOwl:hasBroadSynonym "cusp" ; oboInOwl:hasDbXref "FMA:56481", "NCIT:C94568", "SCTID:362107000", "TAO:0001973", "UMLS:C0226994", "ZFA:0005434" ; oboInOwl:hasExactSynonym "tooth cusp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tooth cone" ; oboInOwl:id "UBERON:0006844" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "cusp of tooth" ; rdfs:subClassOf obo:UBERON_0000476, _:genid144591 . obo:UBERON_0006846 obo:IAO_0000115 "A furrow or an incomplete tube." ; oboInOwl:hasDbXref "AEO:0000161", "EHDAA2_RETIRED:0003161" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "groove" ; oboInOwl:id "UBERON:0006846" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion" ; rdfs:label "surface groove" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/2667" ; rdfs:subClassOf obo:UBERON_0000466, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002255 ] . obo:UBERON_0006847 obo:IAO_0000115 "A nervous system commissure that connects a left hemisphere of cerebellum and connects a right hemisphere of cerebellum." ; oboInOwl:hasDbXref "BAMS:cbc", "DMBA:17754", "FMA:77522", "MBA:744", "TAO:0000490", "ZFA:0000490", "neuronames:1752" ; oboInOwl:hasExactSynonym "commissura cerebelli", "commissure of cerebellum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006847" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "cerebellar commissure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002317 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0014889 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0014890 ] ) ] . obo:UBERON_0006849 obo:IAO_0000115 "Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage." ; obo:UBPROP_0000001 "Endochondral bone that is located medial to the cleithrum, and articulates ventrally with the coracoid, medially with the mesocoracoid when the later is present and posteriorly with the upper one to three proximal radials. The scapula develops from the scapulocoracoid cartilage and belongs to the primary pectoral girdle. It may be perforated by the scapular foramen or it may be notched ventr and forms together with a similar notch of the coracoid the scapulocoracoid foramen[TAO:0000583].", "Paired bony elements of endochondral origin. They are situated at the level of the jaw articulation, in a vertical position, with the suprascapular margin being dorsal and the glenoid end being ventral.[AAO]" ; obo:UBPROP_0000002 "relationship loss: has pars glenoidalis of scapula (AAO:0000753)[AAO]", "relationship loss: part_of scapular area (AAO:0000935)[AAO]" ; obo:UBPROP_0000007 "scapular" ; obo:UBPROP_0000008 "present in all tetrapods with even vestiges of anterior limbs, e.g., turtles & birds & mammals." ; obo:UBPROP_0000011 "chick scapula is of dual origin and segmentally organized" ; oboInOwl:hasAlternativeId "UBERON:0001124", "UBERON:0010904" ; oboInOwl:hasDbXref "AAO:0000751", "BTO:0001218", "CALOHA:TS-0897", "EFO:0001400", "EMAPA:18722", "FMA:13394", "GAID:186", "MA:0001330", "MESH:D012540", "NCIT:C12783", "SCTID:302517007", "TAO:0000583", "UMLS:C0036277", "VHOG:0001398", "VSAO:0000157", "Wikipedia:Scapula", "ZFA:0000583", "galen:Scapula" ; oboInOwl:hasExactSynonym "scapulae" ; oboInOwl:hasNarrowSynonym "shoulder blade" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "scapula bone", "scapulas" ; oboInOwl:id "UBERON:0006849" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim ; a owl:Class ; rdfs:label "scapula" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0007272 ], _:genid144615, _:genid144617, _:genid144619 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015057 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg"^^xsd:anyURI . obo:UBERON_0006855 obo:IAO_0000115 "A muscular coat that is part of a ureter." ; oboInOwl:hasDbXref "EMAPA:28811", "FMA:15893", "MA:0002654", "SCTID:3563003" ; oboInOwl:hasExactSynonym "muscular coat of ureter", "muscular layer of ureter", "muscularis of ureter", "tunica muscularis (ureter)", "tunica muscularis ureteris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ureteral smooth muscle layer" ; oboInOwl:id "UBERON:0006855" ; a owl:Class ; rdfs:label "muscular coat of ureter" ; rdfs:subClassOf _:genid144636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0006858 obo:IAO_0000115 "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]." ; obo:IAO_0000116 "keep this grouping class so long as it is required for GO" ; obo:UBPROP_0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" ; oboInOwl:hasDbXref "VHOG:0001141" ; oboInOwl:hasExactSynonym "adrenal gland - interrenal gland", "adrenal gland/interrenal tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adrenal - interrenal gland", "suprarenal gland - interrenal gland" ; oboInOwl:id "UBERON:0006858" ; oboInOwl:inSubset core:homology_grouping, core:organ_slim ; a owl:Class ; rdfs:label "adrenal/interrenal gland" ; rdfs:subClassOf obo:UBERON_0002368, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010074 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000166 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000457 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 ] . obo:UBERON_0006861 obo:IAO_0000115 "Subdivision of long bone which forms the part of the bone between two metaphyses. Note that the diaphysis includes the metaphyses, but the diaphysis proper excludes these." ; obo:RO_0002171 obo:UBERON_0001438 ; obo:UBPROP_0000012 "The MA class is associated with EMAPA:35505 but we associate this with the more precise concept of diaphyseal plate" ; oboInOwl:hasDbXref "FMA:32688", "MA:0002803" ; oboInOwl:hasExactSynonym "body proper of long bone", "shaft proper of long bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "long bone diaphysis" ; oboInOwl:id "UBERON:0006861" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "diaphysis proper" ; rdfs:subClassOf obo:UBERON_0005055, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004769 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002495 ] . obo:UBERON_0006862 obo:IAO_0000115 "A diaphysis that is part of a femur[Automatically generated definition]." ; obo:UBPROP_0000001 "The body of the femur (or shaft), almost cylindrical in form, is a little broader above than in the center, broadest and somewhat flattened from before backward below. It is slightly arched, so as to be convex in front, and concave behind, where it is strengthened by a prominent longitudinal ridge, the linea aspera. It presents for examination three borders, separating three surfaces. Of the borders, one, the linea aspera, is posterior, one is medial, and the other, lateral[Wikipedia:Body_of_femur]." ; oboInOwl:hasDbXref "EMAPA:37538", "FMA:32847", "MA:0003055", "NCIT:C96209", "SCTID:182048009", "Wikipedia:Body_of_femur" ; oboInOwl:hasExactSynonym "body of femur", "corpus femoris", "femoral diaphysis", "femoral shaft", "shaft of femur" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006862" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "diaphysis of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray244.png"^^xsd:anyURI . obo:UBERON_0006863 obo:IAO_0000115 "A proximal metaphysis that is part of a femur." ; oboInOwl:hasDbXref "FMA:32878" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006863" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal metaphysis of femur" ; rdfs:subClassOf _:genid144676 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143106 ] . obo:UBERON_0006864 obo:IAO_0000115 "A distal metaphysis that is part of a femur." ; oboInOwl:hasDbXref "FMA:32881" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006864" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal metaphysis of femur" ; rdfs:subClassOf _:genid144683 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004377 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:UBERON_0006865 obo:IAO_0000115 "A metaphysis that is part of a femur." ; oboInOwl:hasDbXref "EMAPA:37540", "FMA:32875", "MA:0003052" ; oboInOwl:hasExactSynonym "femoral metaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006865" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metaphysis of femur" ; rdfs:subClassOf _:genid144690 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143118 ] . obo:UBERON_0006866 obo:IAO_0000115 "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." ; obo:IAO_0000232 "this class is the superclass of 'rectum', which is currently reserved for the vertebrate structure. May be merged in future." ; oboInOwl:hasDbXref "FBbt:00005756", "WBbt:0005773" ; oboInOwl:hasNarrowSynonym "rectum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rectal part of digestive tract", "terminal section of digestive tract" ; oboInOwl:id "UBERON:0006866" ; a owl:Class ; rdfs:label "terminal part of digestive tract" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001245 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001046 ] . obo:UBERON_0006867 obo:IAO_0000115 "The anal triangle is the posterior part of the perineum. It contains the anal canal. [WP,unvetted]." ; oboInOwl:hasBroadSynonym "anal region" ; oboInOwl:hasDbXref "FMA:20347", "SCTID:243995004", "Wikipedia:Anal_triangle" ; oboInOwl:hasExactSynonym "anal triangle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "regio analis" ; oboInOwl:id "UBERON:0006867" ; a owl:Class ; rdfs:label "anal part of perineum" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ], _:genid143130, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000159 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png"^^xsd:anyURI . obo:UBERON_0006868 obo:IAO_0000115 "A gland that secretes a seminal fluid." ; oboInOwl:hasDbXref "FBbt:00004958", "WBbt:0006870" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006868" ; oboInOwl:inSubset core:grouping_class, core:organ_slim ; a owl:Class ; rdfs:label "seminal fluid secreting gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006947 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 _:genid143138 ) ] . obo:UBERON_0006871 obo:IAO_0000115 "The distal elements of the developing limb of vertebrates that will give rise to the pes (foot)." ; obo:UBPROP_0000012 "EHDAA2 does not have a single class for footplate, but includes epithelium, mesenchyme and AER" ; oboInOwl:hasAlternativeId "UBERON:0004343" ; oboInOwl:hasBroadSynonym "foot plate", "footplate" ; oboInOwl:hasDbXref "EHDAA:5143", "EHDAA:6096", "EMAPA:17249", "FMA:296800", "NCIT:C34177", "UMLS:C1517291" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal part of hindlimb bud", "foot disk" ; oboInOwl:id "UBERON:0006871" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "embryonic footplate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005418 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010130 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0006872 obo:IAO_0000115 "An apical ectodermal ridge that is part of a handplate." ; oboInOwl:hasDbXref "EHDAA2:0000729", "EMAPA:17247" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006872" ; a owl:Class ; rdfs:label "handplate apical ectodermal ridge" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143152 ] . obo:UBERON_0006875 obo:IAO_0000115 "The distal elements of the developing limb of vertebrates that will give rise to the manus (hand)." ; oboInOwl:hasDbXref "EHDAA:4194", "EHDAA:6242", "EMAPA:17245", "FMA:296794", "NCIT:C34185", "UMLS:C1512334" ; oboInOwl:hasExactSynonym "hand plate", "handplate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal part of forelimb bud" ; oboInOwl:id "UBERON:0006875" ; a owl:Class ; rdfs:label "embryonic handplate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005417 ] ; owl:equivalentClass _:genid143156 . obo:UBERON_0006876 obo:IAO_0000115 "A vasculature that is part of a organ." ; oboInOwl:hasDbXref "FMA:74612" ; oboInOwl:hasExactSynonym "organ vasculature", "set of blood vessels of organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006876" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "vasculature of organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 _:genid143166 ) ] . obo:UBERON_0006877 obo:IAO_0000115 "A vasculature that is part of a liver." ; obo:UBPROP_0000012 "the EHDAA2 term and the FMA term may not be exact equivalents - check" ; oboInOwl:hasDbXref "EHDAA2:0003454", "EMAPA:35501", "FMA:73748" ; oboInOwl:hasExactSynonym "hepatic vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic vascular element", "liver vascular element", "liver vascular system" ; oboInOwl:id "UBERON:0006877" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vasculature of liver" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0006904 obo:IAO_0000115 "A head mesenchyme that develops_from a mesoderm." ; obo:IAO_0000116 "merged in 'head mesoderm' from XAO/AAO and EFO here. Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ; oboInOwl:hasDbXref "AAO:0011051", "EFO:0003337", "EFO:0003603", "EHDAA2:0001118", "EHDAA:655", "EMAPA:16099", "EMAPA_RETIRED:16270", "FMA:293859", "TAO:0000998", "VHOG:0000185", "XAO:0000053", "ZFA:0000998" ; oboInOwl:hasExactSynonym "head mesenchyme derived from mesoderm", "head mesenchyme from head mesoderm", "head mesenchyme from mesoderm", "mesenchyme derived from head mesoderm", "mesenchyme from head mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial mesoderm", "head mesoderm" ; oboInOwl:id "UBERON:0006904" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "head mesenchyme from mesoderm" ; rdfs:subClassOf obo:UBERON_0005253, _:genid144756, _:genid144758 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005253 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ] . obo:UBERON_0006905 obo:IAO_0000115 "Mesenchyme that is part of a mandibular prominence." ; oboInOwl:hasDbXref "EHDAA2:0001062", "EHDAA:5861", "EHDAA:5873", "EMAPA:17357" ; oboInOwl:hasExactSynonym "mesenchyme of mandibular process", "mesenchyme of mandibular prominence" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006905" ; a owl:Class ; rdfs:label "mandibular process mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005867 ] ) ] . obo:UBERON_0006906 obo:IAO_0000115 "The lateral surface parts of the external nose, inferiorly, surrounding the naris[EoM]." ; oboInOwl:hasDbXref "FMA:59519", "SCTID:361345006", "Wikipedia:Ala_of_nose" ; oboInOwl:hasExactSynonym "nasal ala" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ala nasi", "ala of the nose", "wing of nose", "wing of the nose", "wings of the nose" ; oboInOwl:id "UBERON:0006906" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ala of nose" ; rdfs:subClassOf obo:UBERON_0003102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007827 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004067 ], _:genid144773 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png"^^xsd:anyURI . obo:UBERON_0006909 obo:IAO_0000115 "An anatomical space that surrounded_by a digestive tract." ; oboInOwl:hasDbXref "BTO:0000349", "EMAPA:32908", "FMA:45677" ; oboInOwl:hasExactSynonym "digestive tract lumen", "gut cavity", "gut lumen", "lumen of alimentary tract", "lumen of digestive tract", "lumen of gut" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006909" ; a owl:Class ; rdfs:label "lumen of digestive tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ; owl:equivalentClass _:genid143210 . obo:UBERON_0006913 obo:IAO_0000115 "An epithelium that is part of a lip." ; obo:UBPROP_0000001 "The thick, high squamous-stratified epithelium that covers the lips. It contains abundant melanocytes, many mucous cells and has well differentiated taste buds.[TAO]" ; oboInOwl:hasDbXref "BTO:0004468", "TAO:0005334", "ZFA:0005334" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006913" ; a owl:Class ; rdfs:label "lip epithelium" ; owl:equivalentClass _:genid143222 . obo:UBERON_0006914 obo:IAO_0000115 "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." ; obo:UBPROP_0000012 "FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium" ; oboInOwl:hasDbXref "BTO:0002072", "NCIT:C12848", "SCTID:40118003", "UMLS:C0221909", "Wikipedia:Squamous_epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006914" ; a owl:Class ; rdfs:label "squamous epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000076 ] ) ] . obo:UBERON_0006915 obo:IAO_0000115 "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]." ; oboInOwl:hasDbXref "FMA:45563", "NCIT:C13180", "UMLS:C0836131", "Wikipedia:Stratified_squamous_epithelium" ; oboInOwl:hasExactSynonym "epithelium stratificatum squamosum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006915" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "stratified squamous epithelium" ; owl:equivalentClass _:genid143235 . obo:UBERON_0006916 obo:IAO_0000115 "A non-keratinized stratified squamous epithelium that is part of a tongue." ; oboInOwl:hasDbXref "FMA:62130" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006916" ; a owl:Class ; rdfs:label "non-keratinized epithelium of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010304 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0006919 obo:IAO_0000115 "A squamous epithelium that is part of a tongue." ; obo:UBPROP_0000012 "this is a singleton subclass of tongue epithelium in MA" ; oboInOwl:hasDbXref "MA:0002786" ; oboInOwl:hasExactSynonym "squamous epithelium of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006919" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tongue squamous epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005020 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143248 ] . obo:UBERON_0006920 obo:IAO_0000115 "A squamous epithelium that is part of a esophagus." ; obo:UBPROP_0000012 "MA introduces basal and squamous subtypes of esophagus epithelium; consider adding the FMA class 'epithelium of esophagus' here, because it is classified as squamous. BTO also has a singleton subclass" ; oboInOwl:hasDbXref "BTO:0003635", "CALOHA:TS-1250", "EMAPA:35324", "MA:0001567", "NCIT:C49222", "UMLS:C1707950" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "esophageal squamous epithelium", "squamous epithelium of esophagus", "squamous oesophageal epithelium" ; oboInOwl:id "UBERON:0006920" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "esophagus squamous epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006914 _:genid143257 ) ] . obo:UBERON_0006921 obo:IAO_0000115 "A squamous epithelium that is part of a stomach." ; oboInOwl:hasDbXref "EMAPA:35824", "MA:0001611" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006921" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "stomach squamous epithelium" ; rdfs:subClassOf obo:UBERON_0001276 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143266 ] . obo:UBERON_0006922 obo:IAO_0000115 "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." ; oboInOwl:hasDbXref "MA:0001725", "NCIT:C49219", "UMLS:C1707351" ; oboInOwl:hasExactSynonym "cervical squamous epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006922" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "cervix squamous epithelium" ; rdfs:subClassOf obo:UBERON_0010304 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0006923 obo:IAO_0000115 "A squamous epithelium that is part of a vagina." ; oboInOwl:hasDbXref "EMAPA:37794", "MA:0001731", "NCIT:C49314", "UMLS:C1711259" ; oboInOwl:hasExactSynonym "vaginal squamous epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006923" ; a owl:Class ; rdfs:label "vagina squamous epithelium" ; rdfs:subClassOf obo:UBERON_0006915 ; owl:equivalentClass _:genid143276 . obo:UBERON_0006924 obo:IAO_0000115 "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." ; obo:IAO_0000116 "we follow Kardong in treating the glandular epithelium as a distinct entity, and thus as an epithelium which has glands; FMA has 'epithelium of gastric gland', which is part of the gastric gland." ; oboInOwl:hasDbXref "EMAPA:17623", "EMAPA:35814", "FMA:63458", "MA:0002784" ; oboInOwl:hasNarrowSynonym "epithelium of gastric gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric gland epithelium" ; oboInOwl:id "UBERON:0006924" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "stomach glandular epithelium" ; rdfs:subClassOf obo:UBERON_0006929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006931 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000325 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006799 _:genid143285 ) ] . obo:UBERON_0006925 obo:IAO_0000115 "Any gland that is part of the digestive system." ; oboInOwl:hasDbXref "AAO:0000130", "BTO:0000345" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digestive gland" ; oboInOwl:id "UBERON:0006925" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "digestive system gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ] ) ] . obo:UBERON_0006929 obo:IAO_0000115 "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]." ; oboInOwl:hasDbXref "FMA:64800", "NCIT:C13182", "UMLS:C0225337" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006929" ; a owl:Class ; rdfs:label "glandular columnar epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000485 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000150 ] ) ] . obo:UBERON_0006930 oboInOwl:hasDbXref "FMA:66809" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006930" ; a owl:Class ; rdfs:label "glandular cuboidal epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000484 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000150 ] ) ] . obo:UBERON_0006931 obo:IAO_0000115 "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." ; oboInOwl:hasDbXref "EMAPA:27167", "MA:0001614" ; oboInOwl:hasExactSynonym "stomach glandular region glandular mucous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006931" ; a owl:Class ; rdfs:label "stomach glandular region mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001199 _:genid143311 ) ] . obo:UBERON_0006932 obo:IAO_0000115 "An epithelium that is part of a vestibular labyrinth." ; oboInOwl:hasDbXref "BTO:0005581", "EMAPA:32884", "EMAPA:35921", "FMA:75606", "MA:0002892", "RETIRED_EHDAA2:0000834" ; oboInOwl:hasExactSynonym "epithelium of vestibular labyrinth", "inner ear vestibular component epithelium", "vestibular sensory epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006932" ; a owl:Class ; rdfs:label "vestibular epithelium" ; rdfs:subClassOf obo:UBERON_0006934 ; owl:equivalentClass _:genid143315 . obo:UBERON_0006934 obo:IAO_0000115 "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." ; obo:UBPROP_0000012 "note that the definition sourced from Dorlands say 'simple columnar', but FMA says atypical" ; oboInOwl:hasDbXref "CALOHA:TS-0682", "FMA:62410", "SCTID:309045006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neuroepithelium" ; oboInOwl:id "UBERON:0006934" ; a owl:Class ; rdfs:label "sensory epithelium" ; rdfs:subClassOf obo:UBERON_0000488, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000098 ] ) ] . obo:UBERON_0006936 obo:IAO_0000115 "The epithelial cells lining the capsule and trabeculae of the thymus." ; obo:IAO_0000116 "TODO - check whether this is part of the thymus or borders it" ; oboInOwl:hasDbXref "MA:0000769" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006936" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thymus subcapsular epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002294 ] ; owl:equivalentClass _:genid143331 . obo:UBERON_0006937 obo:IAO_0000115 "The epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals." ; oboInOwl:hasDbXref "EMAPA:32883", "MA:0001189" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006937" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "inner ear epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 ] ) ] . obo:UBERON_0006938 obo:IAO_0000115 "An epithelium that is part of a pinna." ; oboInOwl:hasDbXref "EHDAA2:0001470", "EHDAA:8983", "EMAPA:17592", "VHOG:0000632" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006938" ; a owl:Class ; rdfs:label "pinna surface epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 _:genid143344 ) ] . obo:UBERON_0006946 obo:IAO_0000115 "The efferent ducts (or efferent ductules or ductuli efferentes) connect the rete testis with the initial section of the epididymis. The ductuli are unilaminar and composed of columnar ciliated and non-ciliated (absorptive) cells. The ciliated cells serve to stir the luminal fluids, possibly to help ensure homogeneous absorption of water from the fluid produced by the testis, which results in an increase in the concentration of luminal sperm. The epithelium is surrounded by a band of smooth muscle that helps to propel the sperm toward the epididymis." ; obo:UBPROP_0000001 "Any of a group ranging from one to twelve (varies in species) small seminal ducts per testis which transport sperm from the testes to the kidney.[AAO]" ; obo:UBPROP_0000008 "There are two basic designs for efferent ductule structure: a) multiple entries into the epididymis, as seen in most large mammals. In humans and other large mammals, there are approximately 15-20 efferent ducts, which also occupy nearly one third of the head of the epididymis. b) single entry, as seen in most small animals such as rodents, whereby the 3-6 ductules merge into a single small ductule prior to entering the epididymis" ; obo:UBPROP_0000012 "Check EMAPA" ; oboInOwl:hasDbXref "AAO:0010532", "EMAPA:18993", "FMA:19081", "MA:0000398", "NCIT:C32492", "UMLS:C0228013", "Wikipedia:Efferent_ducts" ; oboInOwl:hasExactSynonym "efferent ductule", "seminal duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductuli efferentes testis", "vasa efferentia" ; oboInOwl:id "UBERON:0006946" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "efferent duct" ; rdfs:subClassOf obo:UBERON_0000058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:CL_0000019 ], _:genid143349, [ a owl:Restriction ; owl:onProperty core:channels_into ; owl:someValuesFrom obo:UBERON_0001301 ], _:genid144921 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg"^^xsd:anyURI . obo:UBERON_0006947 obo:IAO_0000115 "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra." ; obo:UBPROP_0000008 "we use this as a generic grouping class for a number of taxa" ; obo:UBPROP_0000012 "in FMA includes as parts: seminal vesicle, efferent ductule (vas efferentia), epididymis, deferent duct (vas deferens), ejaculatory duct" ; oboInOwl:hasAlternativeId "UBERON:0010140" ; oboInOwl:hasDbXref "FMA:55678", "TAO:0001268", "ZFA:0001268" ; oboInOwl:hasExactSynonym "sperm duct", "sperm ducts" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006947" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "male genital duct" ; rdfs:subClassOf obo:UBERON_0000058, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004054 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0001968 ], [ a owl:Restriction ; owl:onProperty core:channels_from ; owl:someValuesFrom obo:UBERON_0000473 ], _:genid144934 . obo:UBERON_0006948 obo:IAO_0000115 "An epithelium that is part of a efferent duct." ; oboInOwl:hasDbXref "EMAPA:29747", "FMA:19195", "MA:0001734" ; oboInOwl:hasExactSynonym "epithelium of efferent ductule of testis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006948" ; a owl:Class ; rdfs:label "efferent duct epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006946 ] ) ] . obo:UBERON_0006953 obo:IAO_0000115 "The ejaculatory duct epithelium is composed of cuboidal to columnar cells between or through which project the terminal parts of the ducts of the unicellular prostate glands." ; obo:IAO_0000116 "TODO - split off insect classes" ; oboInOwl:hasDbXref "BTO:0002618", "EMAPA:29786" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006953" ; a owl:Class ; rdfs:label "ejaculatory duct epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000999 ] ) ] . obo:UBERON_0006955 obo:IAO_0000115 "An epithelium that is part of a uterus." ; oboInOwl:hasDbXref "BTO:0003082" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "uterus epithelium" ; oboInOwl:id "UBERON:0006955" ; a owl:Class ; rdfs:label "uterine epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 _:genid143380 ) ] . obo:UBERON_0006956 obo:IAO_0000115 "The inner lining of the cheeks and lips." ; oboInOwl:hasDbXref "BTO:0003833", "CALOHA:TS-2349", "FMA:59785", "NCIT:C12505", "SCTID:16811007", "UMLS:C1578559" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006956" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "buccal mucosa" ; rdfs:subClassOf obo:UBERON_0000344, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003729 ] . obo:UBERON_0006957 obo:IAO_0000115 "An epithelium that is part of a submandibular gland primordium." ; oboInOwl:hasDbXref "EHDAA2:0001940", "EHDAA:9257", "EMAPA:17756" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submaxillary gland primordium epithelium" ; oboInOwl:id "UBERON:0006957" ; a owl:Class ; rdfs:label "submandibular gland primordium epithelium" ; owl:equivalentClass _:genid143388 . obo:UBERON_0006960 obo:IAO_0000115 "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." ; oboInOwl:hasDbXref "CALOHA:TS-1246", "EMAPA:28880", "FMA:18626", "MA:0002991", "NCIT:C33638", "SCTID:259306002", "UMLS:C0737271", "Wikipedia:Stroma_of_ovary" ; oboInOwl:hasExactSynonym "interstitial tissue of ovary", "ovarian stroma", "ovary stroma", "stroma of the ovary", "stroma ovarica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "stroma ovarii" ; oboInOwl:id "UBERON:0006960" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ovary stroma" ; rdfs:subClassOf _:genid144973 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0006964 obo:IAO_0000115 "The distal part of adenohypophysis: the part that makes up the main body of the gland." ; obo:UBPROP_0000001 "Region of the adenohypophysis which produces the follicle-stimulating hormone, luteinizing hormone, prolactin, thyrotropin, and adrenocorticotropin.[AAO]", "The anterior part of the adenohypophysis. [TFD][VHOG]" ; obo:UBPROP_0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" ; oboInOwl:hasBroadSynonym "DHP", "pars anterior" ; oboInOwl:hasDbXref "AAO:0010542", "BAMS:DHP", "BIRNLEX:1022", "BTO:0001787", "EHDAA2:0001416", "EHDAA:7532", "EMAPA:17515", "FMA:74630", "MA:0000854", "TAO:0001195", "UMLS:C0175322", "VHOG:0000244", "Wikipedia:Pars_distalis", "ZFA:0001195", "neuronames:410" ; oboInOwl:hasExactSynonym "distal part of hypophysis", "pars anterior of adenohypophysis", "pars distalis (glandula pituitaria)", "pars distalis adenohypophysis", "pars distalis of anterior lobe of pituitary gland", "pars glandularis of adenohypophysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior lobe", "distal part of the hypophysis", "pars distalis", "pars distalis (hypophysis)", "pars distalis adenohypophyseos", "pars distalis lobi anterioris hypophyseos", "pars glandularis" ; oboInOwl:id "UBERON:0006964" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "pars distalis of adenohypophysis" ; rdfs:subClassOf obo:UBERON_0000483, _:genid144984 . obo:UBERON_0006965 obo:IAO_0000115 "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." ; oboInOwl:hasDbXref "EFO:0003709", "TAO:0005077", "ZFA:0005077" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006965" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "vascular cord" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014903 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000115 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000566 ], [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0048754 ] . obo:UBERON_0006966 obo:IAO_0000115 "A capillary that is part of the coronary system." ; oboInOwl:hasDbXref "ZFA:0005813" ; oboInOwl:hasExactSynonym "heart capillary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006966" ; a owl:Class ; rdfs:label "coronary capillary" ; rdfs:subClassOf _:genid145016 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0006983 obo:IAO_0000115 "Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010266", "AEO:0000009", "BILA:0000009", "CARO:0000009", "EHDAA2:0003009", "FMA:9658", "TAO:0001839" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006983" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical point" ; rdfs:subClassOf obo:UBERON_0000466 . obo:UBERON_0006984 obo:IAO_0000115 "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n." ; oboInOwl:hasDbXref "BILA:0000010", "CARO:0001002", "EHDAA2_RETIRED:0003192", "FMA:24137", "NCIT:C34022", "UMLS:C1515977" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0006984" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:comment "Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism." ; rdfs:label "anatomical surface" ; rdfs:subClassOf obo:UBERON_0010199 . obo:UBERON_0007005 obo:IAO_0000115 "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." ; obo:IAO_0000116 "consider FBbt:00005541 ! cardiogenic mesoderm", "review EHDAA2 placement" ; oboInOwl:hasDbXref "AAO:0011021", "BILA:0000051", "EFO:0000315", "EHDAA2:0000214", "EHDAA:385", "FMA:293143", "SCTID:360387000", "VHOG:0001641", "XAO:0000235" ; oboInOwl:hasExactSynonym "cardiogenic splanchnopleure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac mesoderm", "cardiogenic mesoderm", "cardiogenic region", "heart primordia" ; oboInOwl:id "UBERON:0007005" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "cardiogenic splanchnic mesoderm" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004140 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009881 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004872 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0009881 ] . obo:UBERON_0007010 obo:IAO_0000115 "Organism at the cleavage stage." ; oboInOwl:hasDbXref "BILA:0000058" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007010" ; a owl:Class ; rdfs:label "cleaving embryo" ; rdfs:subClassOf obo:UBERON_0000922 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002493 ; owl:someValuesFrom obo:UBERON_0000107 ] ) ] . obo:UBERON_0007021 obo:IAO_0000115 "A multicellular organism that is at the juvenile stage." ; obo:UBPROP_0000001 "Whole organism that is not fully grown or sexually mature.[TAO]" ; oboInOwl:hasBroadSynonym "juvenile" ; oboInOwl:hasDbXref "BILA:0000076", "TAO:0002047", "http://neurolex.org/wiki/Category:Juvenile_organism" ; oboInOwl:hasExactSynonym "juvenile organism", "juveniles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007021" ; a owl:Class ; rdfs:label "sexually immature organism" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001190 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid143464 ] . obo:UBERON_0007023 obo:IAO_0000115 "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage." ; obo:UBPROP_0000001 "Whole organism that is fully grown or sexually mature.[TAO]" ; oboInOwl:hasBroadSynonym "adult" ; oboInOwl:hasDbXref "BILA:0000078", "FBbt:00003004", "HAO:0000087", "NCIT:C17600", "TAO:0002046", "UMLS:C0001675", "galen:Adult", "http://neurolex.org/wiki/Category:Adult_organism" ; oboInOwl:hasExactSynonym "adults" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007023" ; a owl:Class ; rdfs:label "adult organism" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 _:genid143476 _:genid143478 ) ] . obo:UBERON_0007026 obo:UBPROP_0000011 "The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis" ; oboInOwl:hasDbXref "BILA:0000084", "NCIT:C34268", "SCTID:360394002", "UMLS:C1514442" ; oboInOwl:hasExactSynonym "future digestive tract", "future digestive tube", "future gut", "primitive gut" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic digestive tube", "primordial digestive tube", "primordial gut" ; oboInOwl:id "UBERON:0007026" ; a owl:Class ; rdfs:label "presumptive gut" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000926 ], _:genid143490 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0007037 oboInOwl:hasDbXref "BILA:0000142" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007037" ; a owl:Class ; rdfs:label "mechanosensory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050954 ] ) ] . obo:UBERON_0007098 obo:IAO_0000115 "Cranial neural crest that migrates into the mandibular arch." ; oboInOwl:hasDbXref "TAO:0007064", "XAO:0000024", "ZFA:0007064" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007098" ; a owl:Class ; rdfs:label "mandibular neural crest" ; rdfs:subClassOf obo:UBERON_0003099, _:genid145076 . obo:UBERON_0007099 obo:IAO_0000115 "Cranial neural crest that migrates into the hyoid arch." ; oboInOwl:hasDbXref "TAO:0007065", "XAO:0000025", "ZFA:0007065" ; oboInOwl:hasExactSynonym "hyoid crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007099" ; a owl:Class ; rdfs:label "hyoid neural crest" ; rdfs:subClassOf obo:UBERON_0003099, _:genid145080 . obo:UBERON_0007100 obo:IAO_0000115 "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." ; obo:UBPROP_0000008 "note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis" ; oboInOwl:hasDbXref "SPD:0000130", "TADS:0000147", "http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg" ; oboInOwl:hasNarrowSynonym "dorsal tube", "heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adult heart" ; oboInOwl:id "UBERON:0007100" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "Gene notes: Bmp, Nkx, Gata" ; rdfs:label "primary circulatory organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002494 ], _:genid145089 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015228 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015 ] ) ] . obo:UBERON_0007115 obo:IAO_0000115 "One of the first set of teeth in the growth development of humans and many other mammals[WP]." ; oboInOwl:hasDbXref "FMA:55655", "GAID:1266", "MESH:D014094", "NCIT:C33745", "SCTID:245612004", "UMLS:C0040455", "Wikipedia:Deciduous_teeth" ; oboInOwl:hasExactSynonym "primary tooth", "temporary tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dentes decidui" ; oboInOwl:id "UBERON:0007115" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "GAT in FMA." ; rdfs:label "deciduous tooth" ; owl:disjointWith obo:UBERON_0007775 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Deciduous_teeth_by_David_Shankbone.jpg"^^xsd:anyURI . obo:UBERON_0007116 obo:IAO_0000115 "The set of teeth first in order or time of development that will be replaced by permanent dentition upon their loss." ; oboInOwl:hasDbXref "FMA:75151", "GAID:1252", "MESH:D014094" ; oboInOwl:hasExactSynonym "baby teeth", "deciduous teeth", "dentes decidui", "milk teeth", "primary teeth", "set of deciduous teeth", "set of primary teeth", "tooth of primary dentition" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deciduous dentition" ; oboInOwl:id "UBERON:0007116" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "primary dentition" ; rdfs:subClassOf obo:UBERON_0003672 . obo:UBERON_0007118 obo:IAO_0000115 "The pit in the center of the abdominal wall marking the point where the umbilical cord entered in the fetus." ; obo:UBPROP_0000007 "omphalo", "umbilical" ; oboInOwl:hasDbXref "FMA:61584", "GAID:29", "MESH:D014472", "NCIT:C77533", "SCTID:243961003", "UMLS:C0041638", "Wikipedia:Navel", "galen:Umbilicus" ; oboInOwl:hasExactSynonym "navel", "umbilical part of abdomen", "umbilical region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007118" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "umbilicus" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002331 ] . obo:UBERON_0007119 obo:IAO_0000115 "The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward." ; oboInOwl:hasDbXref "FMA:42385", "GAID:201", "MESH:D005272", "NCIT:C61563", "SCTID:361792007", "UMLS:C0015815", "Wikipedia:Femur_neck", "galen:NeckOfFemur" ; oboInOwl:hasExactSynonym "femoral neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "collum femoris", "femur neck", "neck of the femur" ; oboInOwl:id "UBERON:0007119" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "neck of femur" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006863 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png"^^xsd:anyURI . obo:UBERON_0007120 obo:IAO_0000115 "The premolar teeth or bicuspids are transitional teeth located between the canine and molar teeth." ; obo:RO_0002161 obo:NCBITaxon_337687 ; obo:UBPROP_0000008 "In humans, there are two premolars per quadrant, making eight premolars total in the mouth. They have at least two cusps. Premolars can be considered as a 'transitional tooth' during chewing, or mastication. It has properties of both the anterior canines and posterior molars, and so food can be transferred from the canines to the premolars and finally to the molars for grinding, instead of directly from the canines to the molars. The premolars in humans are the maxillary first premolar, maxillary second premolar, mandibular first premolar, and the mandibular second premolar. There is always one large buccal cusp, especially so in the mandibular first premolar. The lower second premolar almost always presents with two lingual cusps. Premolar teeth by definition are permanent teeth distal to the canines preceded by deciduous molars. In primitive mammals there are four premolars per quadrant. The most mesial two have been lost in Catarrhines. Paleontologists refer to human premolars as Pm3 and Pm4" ; oboInOwl:hasDbXref "FMA:55637", "GAID:1261", "MESH:D001641", "NCIT:C32201", "SCTID:304572005", "UMLS:C1704302", "Wikipedia:Premolar" ; oboInOwl:hasNarrowSynonym "secondary premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bicuspid", "bicuspid teeth", "bicuspid tooth", "bicuspids", "biscuspid", "dens premolaris", "dentes premolares", "mandibular bicuspid", "maxillary bicuspid", "maxillary premolar", "pm3 (dentistry)", "praemolares", "premolar", "premolar teeth", "premolar tooth", "premolars", "præmolares" ; oboInOwl:id "UBERON:0007120" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "premolar tooth" ; rdfs:subClassOf obo:UBERON_0013164, _:genid145131 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray1003.png"^^xsd:anyURI . obo:UBERON_0007122 obo:IAO_0000115 "A pharyngeal pouch that is between pharyngeal arches 1 and 2." ; obo:UBPROP_0000001 ". [][VHOG]" ; obo:UBPROP_0000003 "In all jawed vertebrates the first arch forms the jaw, while the second arch forms the hyoid apparatus. These two arches are separated by the first pharyngeal pouch and cleft.[well established][VHOG]" ; obo:UBPROP_0000011 "The endoderm lines the future auditory tube (Pharyngotympanic Eustachian tube) , middle ear, mastoid antrum, and inner layer of the tympanic membrane. & origin of Mandibular nerve & Maxillary artery" ; obo:UBPROP_0000012 "we use adjacency relations rather than part_of, as in EHDAA2." ; oboInOwl:hasAlternativeId "UBERON:0005718" ; oboInOwl:hasDbXref "AAO:0011114", "EFO:0003631", "EHDAA2:0000016", "EMAPA:16124", "EMAPA:16125", "FMA:295668", "NCIT:C34176", "SCTID:345248006", "TAO:0001128", "UMLS:C0231068", "VHOG:0000555", "VHOG:0000970", "Wikipedia:Pharyngeal_pouch_(embryology)#First_pouch", "XAO:0000102", "ZFA:0001128" ; oboInOwl:hasExactSynonym "1st arch branchial pouch", "1st arch branchial pouch endoderm", "1st arch pouch endoderm", "1st branchial pouch", "1st pharyngeal pouch endoderm", "first arch pharyngeal pouch", "first visceral pouch", "hyomandibular pouch", "pharyngeal pouches 1", "visceral pouch 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "first pharyngeal pouch" ; oboInOwl:id "UBERON:0007122" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal pouch 1" ; owl:equivalentClass _:genid143572 . obo:UBERON_0007123 obo:IAO_0000115 "A pharyngeal puch that is between the pharyngeal arches 2 and 3." ; obo:UBPROP_0000001 "A pouch that is situated between the 2nd and 3rd pharyngeal arch. [ISBN:0124020607][VHOG]", "Second of the pharyngeal (endodermal) evaginations between the visceral arches from which the Eustachian tube is derived; pouches 2-4 open as gill slits.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000008 "the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils; in rodents, the ventral portion of the second pouch appears to degenerate whereas the remaining part is incorporated into the lateral border of the pharynx; it appears that rodents no longer require tonsils as their function is carried out by the NALT (Nose/Nasal-Associated Lymphoid Tissue) system in the upper respiratory tract." ; obo:UBPROP_0000011 "Contributes to the middle ear, epithelial lining of Crypts (spaces) of the palatine tonsils, supplied by the facial nerve" ; oboInOwl:hasAlternativeId "UBERON:0005715" ; oboInOwl:hasDbXref "AAO:0011115", "EFO:0003633", "EHDAA2:0000058", "EMAPA:16275", "EMAPA:16276", "FMA:295676", "NCIT:C34289", "RETIRED_EHDAA2:0000060", "SCTID:345349000", "TAO:0001130", "UMLS:C0231069", "VHOG:0000561", "VHOG:0000967", "Wikipedia:Pharyngeal_pouch_(embryology)#Second_pouch", "XAO:0000247", "ZFA:0001130" ; oboInOwl:hasExactSynonym "2nd arch branchial pouch", "2nd arch branchial pouch endoderm", "2nd arch pouch endoderm", "2nd branchial pouch", "2nd pharyngeal pouch endoderm", "pharyngeal pouches 2", "second arch pharyngeal pouch", "second visceral pouch", "visceral pouch 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "second pharyngeal pouch" ; oboInOwl:id "UBERON:0007123" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal pouch 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004117 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003114 ] ) ] . obo:UBERON_0007124 obo:IAO_0000115 "A pharyngeal pouch that between pharyngeal arches 3 and 4." ; obo:UBPROP_0000001 "A pouch that is situated between the 3rd and 4th pharyngeal arch. [ISBN:0124020607][VHOG]", "Third of the pharyngeal (endodermal) evaginations between the visceral arches from which the Eustachian tube is derived; pouches 2-4 open as gill slits.[AAO]" ; obo:UBPROP_0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" ; obo:UBPROP_0000011 "The third pouch possesses Dorsal and Ventral wings. Derivatives of the dorsal wings include the inferior parathyroid glands, while the ventral wings fuse to form the cytoreticular cells of the thymus. The main nerve supply to the derivatives of this pouch is Cranial Nerve IX, glossopharyngeal nerve" ; oboInOwl:hasAlternativeId "UBERON:0005716" ; oboInOwl:hasDbXref "AAO:0011116", "EFO:0003634", "EHDAA2:0000077", "EMAPA:16586", "FMA:295682", "NCIT:C34311", "RETIRED_EHDAA2:0000076", "SCTID:345450001", "TAO:0001131", "UMLS:C0231070", "VHOG:0000966", "VHOG:0001030", "Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch", "XAO:0000251", "ZFA:0001131" ; oboInOwl:hasExactSynonym "3rd arch branchial pouch", "3rd arch branchial pouch endoderm", "3rd branchial pouch", "3rd pharyngeal pouch endoderm", "pharyngeal pouches 3", "third arch pharyngeal pouch", "third visceral pouch", "visceral pouch 3" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "third pharyngeal pouch" ; oboInOwl:id "UBERON:0007124" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pharyngeal pouch 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004117 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003115 ] ) ] . obo:UBERON_0007128 obo:IAO_0000115 "Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm." ; oboInOwl:hasDbXref "XAO:0000110" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpuscle", "glomerulus" ; oboInOwl:id "UBERON:0007128" ; a owl:Class ; rdfs:label "glomeral mesenchyme" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 ] . obo:UBERON_0007134 obo:IAO_0000115 "Ganglion which is located in the trunk." ; oboInOwl:hasDbXref "EFO:0000901", "MAT:0000344", "MIAA:0000344", "TAO:0001573", "ZFA:0001573" ; oboInOwl:hasExactSynonym "body ganglion", "trunk ganglia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007134" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "trunk ganglion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0007135 obo:IAO_0000115 "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." ; obo:UBPROP_0000001 "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO]" ; oboInOwl:hasDbXref "EFO:0003497", "TAO:0000131", "ZFA:0000131" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presumptive central nervous system" ; oboInOwl:id "UBERON:0007135" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "neural keel" ; rdfs:subClassOf obo:UBERON_0016879, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003075 ] . obo:UBERON_0007142 obo:IAO_0000115 "An internal carotid artery that branching_part_of a left common carotid artery plus branches." ; oboInOwl:hasDbXref "EMAPA:16329", "FMA:4062", "SCTID:161452006" ; oboInOwl:hasExactSynonym "arteria caritis interna sinistra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007142" ; a owl:Class ; rdfs:label "left internal carotid artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001536 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001532 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001536 ] ) ] . obo:UBERON_0007143 obo:IAO_0000115 "An internal carotid artery that branching_part_of a right common carotid artery plus branches." ; oboInOwl:hasDbXref "EMAPA:16330", "FMA:3949", "SCTID:161251001" ; oboInOwl:hasExactSynonym "arteria carotis interna dextra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007143" ; a owl:Class ; rdfs:label "right internal carotid artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001531 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001532 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001531 ] ) ] . obo:UBERON_0007144 obo:IAO_0000115 "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail." ; obo:UBPROP_0000011 "By the fourth week a clear tail is seen in the human embryo. It recedes after a few weeks and these tissues form what is commonly known as the tailbone (coccyx)." ; oboInOwl:hasDbXref "EMAPA:16748", "FMA:85540" ; oboInOwl:hasExactSynonym "embryo tail", "tail of embryo" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic tail" ; oboInOwl:id "UBERON:0007144" ; a owl:Class ; rdfs:label "embryonic post-anal tail" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0002533 ] . obo:UBERON_0007147 obo:IAO_0000115 "An anatomical cavity that surrounded_by a midgut." ; oboInOwl:hasDbXref "EMAPA:18377", "FMA:54366" ; oboInOwl:hasExactSynonym "midgut lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007147" ; a owl:Class ; rdfs:label "lumen of midgut" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001045 ] ) ] . obo:UBERON_0007148 obo:IAO_0000115 "An anatomical cavity that surrounded_by a hindgut." ; oboInOwl:hasDbXref "EMAPA:18396", "FMA:54367" ; oboInOwl:hasExactSynonym "hindgut lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007148" ; a owl:Class ; rdfs:label "lumen of hindgut" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001046 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001046 ] ) ] . obo:UBERON_0007151 obo:IAO_0000115 "A valve leafleft that is part of a mitral valve." ; obo:UBPROP_0000001 "Leaf of cardiac valve which has as its parts the anterior, and posterior leaflets that is attached to the chorda tendinea of left ventricle and to the frbrous ring of mitral valve." ; obo:UBPROP_0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18628", "FMA:7241", "SCTID:244353007", "VHOG:0000822" ; oboInOwl:hasExactSynonym "leaflet of mitral valve", "mitral valve leaflet", "mitral valvular leaflet" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mitral valve leaflets" ; oboInOwl:id "UBERON:0007151" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mitral valve leaflet" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0005995 ], _:genid145271 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011741 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002135 ] ) ] . obo:UBERON_0007156 obo:IAO_0000115 "The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins." ; oboInOwl:hasDbXref "EMAPA:18763", "FMA:4728", "SCTID:303423007", "Wikipedia:Inferior_thyroid_veins" ; oboInOwl:hasExactSynonym "inferior thyroid venous tree", "vena thyroidea inferioris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007156" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inferior thyroid vein" ; rdfs:subClassOf obo:UBERON_0018246, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0003711 ] . obo:UBERON_0007158 obo:IAO_0000115 "An anatomical cavity that surrounded_by a anal canal." ; oboInOwl:hasDbXref "EMAPA:18836", "FMA:17357" ; oboInOwl:hasExactSynonym "anal canal lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007158" ; a owl:Class ; rdfs:label "lumen of anal canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0007159 obo:IAO_0000115 "An anatomical cavity that surrounded_by a colon." ; oboInOwl:hasDbXref "EMAPA:18945", "FMA:18374", "SCTID:362156004" ; oboInOwl:hasExactSynonym "colon lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "colonic lumen" ; oboInOwl:id "UBERON:0007159" ; a owl:Class ; rdfs:label "lumen of colon" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 _:genid143710 ) ] . obo:UBERON_0007160 obo:IAO_0000115 "The inferior petrosal sinus, within the human head, is an area beneath the brain, which allows blood veins to span the area, from the center of the head downward. It drains from the cavernous sinus (beneath the brain) to the sigmoid sinuses above the internal jugular vein." ; oboInOwl:hasDbXref "EMAPA:19234", "FMA:50770", "SCTID:279263009", "Wikipedia:Inferior_petrosal_sinus" ; oboInOwl:hasExactSynonym "sinus petrosal inferior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007160" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inferior petrosal sinus" ; rdfs:subClassOf obo:UBERON_0017635, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001586 ] . obo:UBERON_0007171 oboInOwl:hasDbXref "EMAPA:25124", "FMA:23797" ; oboInOwl:hasExactSynonym "scapular border" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007171" ; a owl:Class ; rdfs:label "border of scapula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036304 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] . obo:UBERON_0007172 oboInOwl:hasDbXref "EMAPA:25125", "FMA:23800" ; oboInOwl:hasExactSynonym "scapular angle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007172" ; a owl:Class ; rdfs:label "angle of scapula" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/58"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006849 ] . obo:UBERON_0007173 obo:IAO_0000115 "The lateral border (or axillary border, or margin) is the thickest of the three borders of the scapula. It begins above at the lower margin of the glenoid cavity, and inclines obliquely downward and backward to the inferior angle. Immediately below the glenoid cavity is a rough impression, the infraglenoid tuberosity, about 2.5 cm. in length, which gives origin to the long head of the Triceps brachii; in front of this is a longitudinal groove, which extends as far as the lower third of this border, and affords origin to part of the Subscapularis. The inferior third is thin and sharp, and serves for the attachment of a few fibers of the Teres major behind, and of the Subscapularis in front." ; oboInOwl:hasDbXref "EMAPA:25126", "FMA:23239", "Wikipedia:Lateral_border_of_the_scapula" ; oboInOwl:hasExactSynonym "axillary border of scapula", "lateral border of scapula", "margo lateralis (scapula)", "margo lateralis scapulae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral part of scapula" ; oboInOwl:id "UBERON:0007173" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lateral border of scapula" ; rdfs:subClassOf obo:UBERON_0007171 ; owl:disjointWith obo:UBERON_0007174 . obo:UBERON_0007174 obo:IAO_0000115 "The medial border of the scapula (vertebral border, medial margin) is the longest of the three borders, and extends from the medial to the inferior angle. It is arched, intermediate in thickness between the superior and the axillary borders, and the portion of it above the spine forms an obtuse angle with the part below. This border presents an anterior and a posterior lip, and an intermediate narrow area. The anterior lip affords attachment to the Serratus anterior; the posterior lip, to the Supraspinatus above the spine, the Infraspinatus below; the area between the two lips, to the Levator scapulC& above the triangular surface at the commencement of the spine, to the Rhomboideus minor on the edge of that surface, and to the Rhomboideus major below it; this last is attached by means of a fibrous arch, connected above to the lower part of the triangular surface at the base of the spine, and below to the lower part of the border." ; obo:IAO_0000116 "consider merging with UBERON:1500000 scapular blade, depending on https://github.com/obophenotype/uberon/issues/339. See also http://www.ncbi.nlm.nih.gov/pubmed/20136669" ; oboInOwl:hasDbXref "EMAPA:25127", "FMA:23242", "SCTID:368187009", "Wikipedia:Medial_border_of_scapula" ; oboInOwl:hasExactSynonym "margo medialis (scapula)", "margo medialis scapulae", "medial part of scapula", "vertebral border of scapula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial border of the scapula", "medial margin of the scapula", "vertebral border", "vertebral border of the scapula" ; oboInOwl:id "UBERON:0007174" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medial border of scapula" ; rdfs:subClassOf obo:UBERON_0007171, _:genid145319 . obo:UBERON_0007175 obo:IAO_0000115 "An angle of the scapula formed by the union of the vertebral and axillary borders; its dorsal surface affords attachment to the Teres major and frequently to a few fibers of the Latissimus dorsi.[WP,unvetted]." ; oboInOwl:hasDbXref "EMAPA:25128", "FMA:13315", "Wikipedia:Inferior_angle_of_scapula" ; oboInOwl:hasExactSynonym "angulus inferior (scapula)", "angulus inferior scapulae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007175" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inferior angle of scapula" ; rdfs:subClassOf obo:UBERON_0007172 . obo:UBERON_0007177 obo:IAO_0000115 "A lamina propria that is part of a colonic mucosa." ; oboInOwl:hasDbXref "EMAPA:27395", "FMA:15657", "MA:0003196", "SCTID:113284008" ; oboInOwl:hasExactSynonym "colonic lamina propria", "lamina propria mucosae of colon", "lamina propria of colonic mucosa", "lamina propria of colonic mucous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007177" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lamina propria of mucosa of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000317 ] ) ] . obo:UBERON_0007181 obo:IAO_0000115 "A serous membrane that is part of a uterine tube infundibulum." ; oboInOwl:hasDbXref "EMAPA:29903", "FMA:18324" ; oboInOwl:hasExactSynonym "serosa of infundibulum of fallopian tube", "serosa of infundibulum of oviduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007181" ; a owl:Class ; rdfs:label "serosa of infundibulum of uterine tube" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003983 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003984 ] ) ] . obo:UBERON_0007182 obo:IAO_0000115 "A muscle layer that is part of a uterine tube infundibulum." ; oboInOwl:hasDbXref "EMAPA:31264", "FMA:18336" ; oboInOwl:hasExactSynonym "muscle layer of infundibulum of fallopian tube", "muscle layer of infundibulum of oviduct", "muscularis of infundibulum of uterine tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007182" ; a owl:Class ; rdfs:label "muscle layer of infundibulum of uterine tube" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003983 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003984 ] ) ] . obo:UBERON_0007188 obo:IAO_0000115 "A mesothelium that is part of a serous pericardium." ; oboInOwl:hasDbXref "BTO:0003157", "EMAPA:16133", "FMA:18149", "SCTID:67300002" ; oboInOwl:hasExactSynonym "mesothelium of pericardium", "pericardial mesothelium", "serous pericardium mesothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007188" ; a owl:Class ; rdfs:label "mesothelium of serous pericardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001136 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002357 ] ) ] . obo:UBERON_0007195 obo:IAO_0000115 "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." ; oboInOwl:hasDbXref "CALOHA:TS-0085", "FMA:21426", "Wikipedia:Bone_marrow#Stroma" ; oboInOwl:hasExactSynonym "bone marrow stroma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007195" ; a owl:Class ; rdfs:label "stroma of bone marrow" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002240 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000332 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002371 ] ) ] . obo:UBERON_0007196 obo:IAO_0000115 "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." ; oboInOwl:hasAlternativeId "UBERON:0004102" ; oboInOwl:hasDbXref "FMA:7393", "NCIT:C117875", "SCTID:361384001", "Wikipedia:Tracheobronchial_tree" ; oboInOwl:hasExactSynonym "arbor tracheobronchialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tracheobronchial system" ; oboInOwl:id "UBERON:0007196" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "tracheobronchial tree" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001558 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002185 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003126 ], _:genid145380 . obo:UBERON_0007197 obo:IAO_0000115 "Multicellular organism that can produce both male and female gametes." ; oboInOwl:hasDbXref "AAO:0010035", "BILA:0000029", "CARO:0000029", "HAO:0000029", "TADS:0000601", "WBbt:0007849" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dioecious organism", "hermaphrodite" ; oboInOwl:id "UBERON:0007197" ; a owl:Class ; rdfs:label "hermaphroditic organism" ; rdfs:subClassOf obo:UBERON_0000468 . obo:UBERON_0007198 obo:IAO_0000115 "An anatomical structure present only in hermaphrodites." ; oboInOwl:hasDbXref "AEO:0000177", "EHDAA2:0003177", "WBbt:0005758" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hermaphrodite-specific" ; oboInOwl:id "UBERON:0007198" ; a owl:Class ; rdfs:label "hermaphrodite anatomical structure" ; owl:equivalentClass _:genid143803 . obo:UBERON_0007204 obo:IAO_0000115 "The vasculature consisting of brachiocephalic arteries and veins." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007204" ; a owl:Class ; rdfs:label "brachiocephalic vasculature" ; rdfs:subClassOf obo:UBERON_0002049 . obo:UBERON_0007213 obo:IAO_0000115 "Mesenchyme that develops_from a cranial neural crest." ; oboInOwl:hasDbXref "EFO:0003572", "EHDAA2:0000735", "EMAPA:16169", "EMAPA:16271", "EMAPA_RETIRED:16271", "TAO:0000787", "ZFA:0000787" ; oboInOwl:hasExactSynonym "head mesenchyme from cranial neural crest", "head mesenchyme from neural crest", "head neural crest derived mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007213" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "mesenchyme derived from head neural crest" ; rdfs:subClassOf obo:UBERON_0005253 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003099 ] ) ] . obo:UBERON_0007214 obo:IAO_0000115 "Mesenchyme that develops_from a trunk neural crest." ; oboInOwl:hasDbXref "EHDAA2:0002093", "EMAPA:16182", "TAO:0000999", "ZFA:0000999" ; oboInOwl:hasExactSynonym "trunk mesenchyme from neural crest", "trunk neural crest derived mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007214" ; oboInOwl:inSubset core:vertebrate_core ; a owl:Class ; rdfs:label "mesenchyme derived from trunk neural crest" ; rdfs:subClassOf obo:UBERON_0005256 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003083 ] ) ] . obo:UBERON_0007220 obo:IAO_0000115 "An embryo stage that covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." ; oboInOwl:hasDbXref "EV:0300011", "EVM:2990031", "FBdv:00005333", "FMA:63631", "MIAA:0000399", "MmusDv:0000031", "OGES:000023", "SCTID:367619004" ; oboInOwl:hasExactSynonym "embryo late (growth) stage" ; oboInOwl:hasNarrowSynonym "fetal stage", "fetus", "fetus stage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryo late growth stage", "embryo late stage" ; oboInOwl:id "UBERON:0007220" ; a owl:Class ; rdfs:label "late embryonic stage" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/355"^^xsd:anyURI, "https://github.com/obophenotype/uberon/issues/565"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000105, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000068 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000111 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0004707 ] . obo:UBERON_0007223 obo:IAO_0000115 "The osseous cochlea is the bony foundation that forms the small shell arrangement for the cochlear nerve." ; obo:IAO_0000116 "TODO - check this. in MA, cochlea is not part of the bony labyrinth" ; oboInOwl:hasDbXref "EMAPA:35620", "MA:0000239" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007223" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "osseus cochlea" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001839 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001844 ] . obo:UBERON_0007228 obo:IAO_0000115 "A cranial nucleus for the vestibular nerve. [WP,unvetted]." ; oboInOwl:hasDbXref "CALOHA:TS-2078", "EMAPA:35923", "EV:0100254", "FMA:54602", "MA:0001032", "NCIT:C12821", "SCTID:362462004", "UMLS:C0042600", "Wikipedia:Vestibular_nuclei" ; oboInOwl:hasExactSynonym "vestibular VIII nucleus", "vestibular nucleus of acoustic nerve", "vestibular nucleus of eighth cranial nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007228" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "See comments for 'vestibular nuclear complex." ; rdfs:label "vestibular nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0003723 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002673 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png"^^xsd:anyURI . obo:UBERON_0007237 obo:IAO_0000116 "relationship to Meckel's cartilage to be added" ; obo:UBPROP_0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000031", "EHDAA:583", "EMAPA:16382", "VHOG:0000510" ; oboInOwl:hasExactSynonym "ventral pharyngeal arch 1" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventral mandibular arch", "ventral visceral arch 1" ; oboInOwl:id "UBERON:0007237" ; a owl:Class ; rdfs:label "1st arch mandibular component" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid145432 . obo:UBERON_0007238 obo:IAO_0000116 "relationship to palatoquadrate to be added" ; obo:UBPROP_0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000038", "EHDAA:595", "EMAPA:16388", "VHOG:0000511" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007238" ; a owl:Class ; rdfs:label "1st arch maxillary component" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid145439 . obo:UBERON_0007239 obo:IAO_0000115 "A tunica media that is part of a artery." ; oboInOwl:hasDbXref "EMAPA:36294", "EV:0100029", "FMA:14273", "NCIT:C49321", "SCTID:84300001", "UMLS:C1710627" ; oboInOwl:hasExactSynonym "arterial media", "tunica media (arteriae)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007239" ; a owl:Class ; rdfs:label "tunica media of artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000415 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0007240 obo:IAO_0000115 "A tunica adventitia that is part of a artery." ; oboInOwl:hasDbXref "EMAPA:36295", "EV:0100030", "FMA:14274", "SCTID:113261001" ; oboInOwl:hasExactSynonym "arterial adventitia", "tunica externa (adventitia)(arteriae)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007240" ; a owl:Class ; rdfs:label "tunica adventitia of artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000415 ], _:genid145456 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005734 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0007241 obo:IAO_0000115 "A tunica adventitia that is part of a vein." ; oboInOwl:hasDbXref "EMAPA:36310", "EV:0100034", "FMA:14355", "SCTID:13202006" ; oboInOwl:hasExactSynonym "tunica externa (adventitia)(venae)", "venous adventitia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007241" ; a owl:Class ; rdfs:label "tunica adventitia of vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005734 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0007242 obo:IAO_0000115 "A tunica intima that is part of a vein." ; oboInOwl:hasDbXref "EMAPA:36308", "EV:0100032", "FMA:14353", "SCTID:2436009" ; oboInOwl:hasExactSynonym "tunica interna (intima)(venae)", "venous intima" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007242" ; a owl:Class ; rdfs:label "tunica intima of vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002523 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0007243 obo:IAO_0000115 "A tunica media that is part of a vein." ; oboInOwl:hasDbXref "EMAPA:36309", "EV:0100033", "FMA:14354", "SCTID:42049001" ; oboInOwl:hasExactSynonym "tunica media (venae)", "venous media" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007243" ; a owl:Class ; rdfs:label "tunica media of vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002522 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0007245 obo:IAO_0000115 "Gray matter of the central nervous system which is a collection of clustered nuclei." ; oboInOwl:hasDbXref "FMA:256381", "FMA:84059" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cluster of neural nuclei", "neural nuclei", "nuclear complex" ; oboInOwl:id "UBERON:0007245" ; a owl:Class ; rdfs:label "nuclear complex of neuraxis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000125 ] ) ] . obo:UBERON_0007247 obo:IAO_0000115 "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei." ; obo:IAO_0000232 "this class exists largely for consistency with the FMA. It is defined trivially with respect to the SOC. The class may be removed in future." ; oboInOwl:hasDbXref "FMA:72246", "SCTID:369024009" ; oboInOwl:hasExactSynonym "superior olivary complex nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007247" ; oboInOwl:inSubset core:grouping_class, core:pheno_slim ; a owl:Class ; rdfs:label "nucleus of superior olivary complex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002128 ] ) ] . obo:UBERON_0007250 obo:IAO_0000115 "The lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue." ; oboInOwl:hasDbXref "FMA:54836", "MA:0000773", "NCIT:C32988", "SCTID:276957006", "UMLS:C0229871", "Wikipedia:Lingual_tonsils" ; oboInOwl:hasExactSynonym "lingual tonsillar tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tonsilla lingualis" ; oboInOwl:id "UBERON:0007250" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lingual tonsil" ; rdfs:subClassOf obo:UBERON_0002372, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001735 ], _:genid145494 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg"^^xsd:anyURI . obo:UBERON_0007252 obo:IAO_0000115 "An intervertebral disk that is part of a cervical region of vertebral column. A cervical intervertebral disk connects at least one cervical vertebra, either to another cervical vertebra, or at one point on the vertebral colummn, to a thoracic vertebra." ; oboInOwl:hasDbXref "EMAPA:19415", "FMA:13895", "SCTID:68818006" ; oboInOwl:hasExactSynonym "cervical intervertebral disc", "intervertebral disc of cervical region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007252" ; a owl:Class ; rdfs:label "intervertebral disk of cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006072 ] ) ] . obo:UBERON_0007254 obo:IAO_0000115 "An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connects at least one thoracic vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a lumbar vertebra." ; oboInOwl:hasDbXref "EMAPA:19489", "FMA:10455" ; oboInOwl:hasExactSynonym "intervertebral disc of thoracic region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007254" ; a owl:Class ; rdfs:label "intervertebral disk of thoracic vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006073 ] ) ] . obo:UBERON_0007255 obo:IAO_0000115 "An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least one lumbar vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." ; oboInOwl:hasDbXref "EMAPA:19468", "FMA:13894" ; oboInOwl:hasExactSynonym "intervertebral disc of lumbar region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007255" ; a owl:Class ; rdfs:label "intervertebral disk of lumbar vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006074 ] ) ] . obo:UBERON_0007257 obo:IAO_0000115 "An intervertebral disk that is part of a sacral region of vertebral column. A sacral intervertebral disk connects at least one sacral vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." ; oboInOwl:hasDbXref "EMAPA:19575", "FMA:268676" ; oboInOwl:hasExactSynonym "intervertebral disc of sacral region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007257" ; a owl:Class ; rdfs:label "intervertebral disk of sacral vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006075 ] ) ] . obo:UBERON_0007260 obo:IAO_0000115 "An intervertebral disk that connects a mammalian cervical vertebra 3 and connects a mammalian cervical vertebra 4." ; oboInOwl:hasDbXref "EMAPA:19422", "FMA:13896" ; oboInOwl:hasExactSynonym "C3 intervertebral disk", "intervertebral disk, C3-C4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007260" ; a owl:Class ; rdfs:label "intervertebral disk of third cervical vertebra" ; rdfs:subClassOf obo:UBERON_0007252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004612 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004613 ] ) ] . obo:UBERON_0007261 obo:IAO_0000115 "An intervertebral disk that connects a mammalian cervical vertebra 4 and connects a mammalian cervical vertebra 5." ; oboInOwl:hasDbXref "EMAPA:19425", "FMA:13897", "SCTID:361748005" ; oboInOwl:hasExactSynonym "intervertebral disc of fourth cervical vertebra", "intervertebral disk, C4-C5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007261" ; a owl:Class ; rdfs:label "intervertebral disk of fourth cervical vertebra" ; rdfs:subClassOf obo:UBERON_0007252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004613 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004614 ] ) ] . obo:UBERON_0007262 obo:IAO_0000115 "An intervertebral disk that connects a mammalian cervical vertebra 5 and connects a mammalian cervical vertebra 6." ; oboInOwl:hasDbXref "EMAPA:19428", "FMA:13898", "SCTID:361749002" ; oboInOwl:hasExactSynonym "intervertebral disc of fifth cervical vertebra", "intervertebral disk, C5-C6" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007262" ; a owl:Class ; rdfs:label "intervertebral disk of fifth cervical vertebra" ; rdfs:subClassOf obo:UBERON_0007252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004614 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004615 ] ) ] . obo:UBERON_0007265 obo:IAO_0000115 "An intervertebral disk that connects a vertebral bone 2 and connects a mammalian cervical vertebra 3." ; oboInOwl:hasDbXref "EMAPA:19419", "FMA:25058" ; oboInOwl:hasExactSynonym "C2 disk", "C2 intervertebral disk", "intervertebral disc of cervical vertebra 2", "intervertebral disc of second cervical vertebra", "intervertebral disk of cervical vertebra 2", "intervertebral disk of second cervical vertebra", "intervertebral disk, C2-C3", "second cervical intervertebral disk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007265" ; a owl:Class ; rdfs:label "intervertebral disk of axis" ; rdfs:subClassOf obo:UBERON_0007252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001093 ] _:genid143968 ) ] . obo:UBERON_0007266 obo:IAO_0000115 "An intervertebral disk that connects a vertebral bone 1 and connects a vertebral bone 2." ; oboInOwl:hasDbXref "EMAPA:19416" ; oboInOwl:hasExactSynonym "C1 disk", "C1 intervertebral disk", "first cervical intervertebral disk", "intervertebral disc of cervical vertebra 1", "intervertebral disc of first cervical vertebra", "intervertebral disk of cervical vertebra 1", "intervertebral disk of first cervical vertebra", "intervertebral disk, C1-C2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007266" ; a owl:Class ; rdfs:label "intervertebral disk of atlas" ; rdfs:subClassOf obo:UBERON_0007252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001066 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001092 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001093 ] ) ] . obo:UBERON_0007267 obo:IAO_0000115 "A pre-cartilage condensation that is part of a trachea." ; oboInOwl:hasDbXref "EHDAA2:0002070", "EHDAA:7082" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007267" ; a owl:Class ; rdfs:label "trachea pre-cartilage rings" ; rdfs:subClassOf _:genid145579 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0007269 obo:IAO_0000115 "Any collection of muscles that is part of a pectoral appendage." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "EFO:0003540", "TAO:0000563", "ZFA:0000563" ; oboInOwl:hasNarrowSynonym "pectoral fin muscle", "pectoral fin musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007269" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "pectoral appendage musculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0007270 obo:IAO_0000115 "Any collection of muscles that is part of a pelvic appendage." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; obo:UBPROP_0000001 "Musculature that is part of the pelvic fin.[TAO]" ; oboInOwl:hasDbXref "TAO:0000258", "ZFA:0000258" ; oboInOwl:hasNarrowSynonym "pelvic fin musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007270" ; a owl:Class ; rdfs:label "pelvic appendage musculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0007271 obo:IAO_0000115 "Any collection of muscles that is part of an appendage." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "TAO:0000207", "ZFA:0000207" ; oboInOwl:hasNarrowSynonym "fin musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007271" ; a owl:Class ; rdfs:label "appendage musculature" ; owl:equivalentClass _:genid144006 . obo:UBERON_0007272 obo:IAO_0000115 "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." ; obo:RO_0002475 obo:UBERON_0007273 ; oboInOwl:hasDbXref "VSAO:0005000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cheiropterygium" ; oboInOwl:id "UBERON:0007272" ; a owl:Class ; rdfs:label "pectoral appendage skeleton" ; rdfs:subClassOf _:genid145606 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0007273 obo:IAO_0000115 "The collection of all skeletal elements in a pelvic appendage region." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007273" ; a owl:Class ; rdfs:label "pelvic appendage skeleton" ; rdfs:subClassOf _:genid145614 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0007277 obo:IAO_0000115 "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." ; obo:IAO_0000116 "TODO - unify naming conventions" ; obo:UBPROP_0000001 "The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]." ; oboInOwl:hasDbXref "BAMS:HB", "CALOHA:TS-2118", "EFO:0003440", "EHDAA2:0001630", "FMA:295640", "TAO:0000569", "Wikipedia:Rhombencephalon", "ZFA:0000569" ; oboInOwl:hasExactSynonym "presumptive rhombencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic rhombencephalon", "future hindbrain", "rhombencephalon" ; oboInOwl:id "UBERON:0007277" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive hindbrain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006238 ], _:genid145622, _:genid145624 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0007278 obo:IAO_0000115 "Portion of tissue that is part of the heart tube and will become the sinus venosus." ; oboInOwl:hasDbXref "TAO:0002234", "ZFA:0001722" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007278" ; a owl:Class ; rdfs:label "presumptive sinus venosus" ; rdfs:subClassOf _:genid145636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002063 ] ) ] . obo:UBERON_0007279 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a atrioventricular canal." ; obo:UBPROP_0000001 "Portion of tissue that is part of the heart tube and will become the atrioventricular canal.[TAO]" ; oboInOwl:hasDbXref "TAO:0002227", "ZFA:0001723" ; oboInOwl:hasExactSynonym "future AV canal", "future atrioventricular canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007279" ; a owl:Class ; rdfs:label "presumptive atrioventricular canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004141 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002087 ] ) ] . obo:UBERON_0007280 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a endocardium." ; obo:UBPROP_0000001 "Portion of tissue that is part of the heart tube and will become the endocardium.[TAO]" ; oboInOwl:hasDbXref "TAO:0002233", "ZFA:0001724" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007280" ; a owl:Class ; rdfs:label "presumptive endocardium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005498 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003084 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002165 ] ) ] . obo:UBERON_0007281 obo:IAO_0000115 "Embryonic structure that gives rise to the midbrain hindbrain boundary." ; oboInOwl:hasDbXref "EFO:0003446", "TAO:0001187", "XAO:0004086", "ZFA:0001187" ; oboInOwl:hasExactSynonym "presumptive MHB", "presumptive midbrain-hindbrain boundary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007281" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive midbrain hindbrain boundary" ; rdfs:subClassOf _:genid145658 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003052 ] ) ] . obo:UBERON_0007282 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a presomitic mesoderm." ; oboInOwl:hasDbXref "EFO:0003421", "TAO:0000053", "ZFA:0000053" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presumptive segmental plates" ; oboInOwl:id "UBERON:0007282" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive segmental plate" ; rdfs:subClassOf _:genid145667 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003059 ] ) ] . obo:UBERON_0007284 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a neural plate." ; obo:IAO_0000116 "consider merging" ; obo:UBPROP_0000001 "Region of the gastrula which gives rise to the neural plate.[TAO]" ; oboInOwl:hasDbXref "EFO:0003424", "TAO:0000063", "ZFA:0000063" ; oboInOwl:hasExactSynonym "prospective neuroectoderm", "prospective vegetal ectoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007284" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive neural plate" ; rdfs:subClassOf obo:UBERON_0016879, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004734 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003075 ] ) ] . obo:UBERON_0007285 obo:IAO_0000115 "The part of the blastula that has the potential to develop into a paraxial mesoderm." ; oboInOwl:hasDbXref "EFO:0003443", "TAO:0000591", "XAO:0004134", "ZFA:0000591" ; oboInOwl:hasExactSynonym "future paraxial mesenchyme", "future paraxial mesoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007285" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive paraxial mesoderm" ; owl:equivalentClass _:genid145681 . obo:UBERON_0007288 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a forebrain-midbrain boundary." ; oboInOwl:hasDbXref "EFO:0003463", "TAO:0001368", "ZFA:0001368" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007288" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive forebrain midbrain boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006238 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005075 ] ) ] . obo:UBERON_0007289 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a rhombomere 1." ; oboInOwl:hasDbXref "TAO:0001207", "ZFA:0001207" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007289" ; a owl:Class ; rdfs:label "presumptive rhombomere 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005499 ] ) ] . obo:UBERON_0007297 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a pronephric mesoderm." ; oboInOwl:hasDbXref "EFO:0003619", "TAO:0001070", "ZFA:0001070" ; oboInOwl:hasExactSynonym "nephron primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007297" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive pronephric mesoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005721 ] ) ] . obo:UBERON_0007299 obo:IAO_0000115 "A choroid plexus that is part of a cerebral aqueduct." ; oboInOwl:hasDbXref "TAO:0001445", "ZFA:0001445" ; oboInOwl:hasExactSynonym "choroid plexus tectal ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "choroid plexus tectal ventricles" ; oboInOwl:id "UBERON:0007299" ; a owl:Class ; rdfs:label "choroid plexus of tectal ventricle" ; owl:equivalentClass _:genid144109 . obo:UBERON_0007300 obo:IAO_0000115 "A blood vessel that is part of a pectoral appendage." ; oboInOwl:hasDbXref "TAO:0005301", "ZFA:0005301" ; oboInOwl:hasNarrowSynonym "pectoral fin blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007300" ; a owl:Class ; rdfs:label "pectoral appendage blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0007301 obo:IAO_0000115 "A blood vessel that is part of a limb/fin." ; oboInOwl:hasDbXref "TAO:0005299", "ZFA:0005299" ; oboInOwl:hasNarrowSynonym "fin blood vessel", "limb blood vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007301" ; a owl:Class ; rdfs:label "appendage blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007304 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ] ) ] . obo:UBERON_0007302 obo:IAO_0000115 "A vasculature that is part of a pectoral appendage." ; oboInOwl:hasDbXref "TAO:0005096", "ZFA:0005096" ; oboInOwl:hasNarrowSynonym "pectoral fin vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007302" ; a owl:Class ; rdfs:label "pectoral appendage vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 _:genid144132 ) ] . obo:UBERON_0007303 obo:IAO_0000115 "A vasculature that is part of a chordate pharynx." ; oboInOwl:hasDbXref "TAO:0005003", "ZFA:0005003" ; oboInOwl:hasExactSynonym "branchial vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007303" ; a owl:Class ; rdfs:label "pharyngeal vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0007304 obo:IAO_0000115 "A vasculature that is part of a limb/fin." ; oboInOwl:hasDbXref "TAO:0005095", "ZFA:0005095" ; oboInOwl:hasNarrowSynonym "fin vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007304" ; a owl:Class ; rdfs:label "appendage vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ] ) ] . obo:UBERON_0007306 obo:IAO_0000115 "A glomerular capillary that is part of a pronephros." ; oboInOwl:hasDbXref "TAO:0005309", "ZFA:0005309" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007306" ; a owl:Class ; rdfs:label "pronephric glomerular capillary" ; rdfs:subClassOf _:genid145750, _:genid145752 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004212 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:UBERON_0007307 obo:IAO_0000115 "A glomerular basement membrane that is part of a pronephros." ; oboInOwl:hasDbXref "TAO:0005313", "ZFA:0005313" ; oboInOwl:hasExactSynonym "pronephric glomerular filtration membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007307" ; a owl:Class ; rdfs:label "pronephric glomerular basement membrane" ; rdfs:subClassOf _:genid145759 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005777 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002120 ] ) ] . obo:UBERON_0007312 obo:IAO_0000115 "Either the internal or external pudendal arteries." ; oboInOwl:hasDbXref "EMAPA:37111", "MA:0002028", "SCTID:277968003", "Wikipedia:Pudendal_artery" ; oboInOwl:hasExactSynonym "arteriae pudendae", "arteriae pudendales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007312" ; a owl:Class ; rdfs:label "pudendal artery" ; rdfs:subClassOf obo:UBERON_0001637 . obo:UBERON_0007315 obo:IAO_0000115 "The internal pudendal artery is an artery that branches off the internal iliac artery, providing blood to the external genitalia. The internal pudendal artery is the terminal branch of the anterior trunk of the internal iliac artery. It is smaller in the female than in the male." ; oboInOwl:hasBroadSynonym "internal pudendal vessels" ; oboInOwl:hasDbXref "FMA:18835", "SCTID:244309002", "Wikipedia:Internal_pudendal_artery" ; oboInOwl:hasExactSynonym "arteria pudenda interna", "arteriae pudendae interna", "arteriae pudendales interna", "internal pudic artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007315" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "internal pudendal artery" ; rdfs:subClassOf obo:UBERON_0007312, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006867 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001309 ], _:genid145768 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png"^^xsd:anyURI . obo:UBERON_0007318 obo:IAO_0000115 "Either of two main superficial veins of the leg, one larger than the other, that begin at the foot." ; oboInOwl:hasDbXref "BTO:0001808", "CALOHA:TS-0893", "EMAPA:37186", "MA:0002215", "MESH:D012501", "NCIT:C33511", "UMLS:C0036186" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007318" ; a owl:Class ; rdfs:label "saphenous vein" ; rdfs:subClassOf obo:UBERON_0035550, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] . obo:UBERON_0007324 obo:IAO_0000115 "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." ; obo:IAO_0000116 "TODO - check" ; obo:UBPROP_0000008 "In mice many lobules lack islets, in contrast to other mammals including humans" ; oboInOwl:hasDbXref "EMAPA:37710", "FMA:16012", "MA:0000721" ; oboInOwl:hasExactSynonym "lobulus pancreaticus", "pancreas lobe", "pancreatic lobule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007324" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pancreatic lobule" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001263 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0014719 ] . obo:UBERON_0007329 obo:IAO_0000115 "A duct that collects and carries secretions of the exocrine pancreas to the intestine." ; obo:IAO_0000232 "this class groups together accessory (dorsal) and main (ventral) pancreatic ducts" ; obo:UBPROP_0000001 "Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; obo:UBPROP_0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" ; obo:UBPROP_0000012 "in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms" ; oboInOwl:hasDbXref "EHDAA:9194", "EMAPA:32952", "FMA:10419", "MA:0000124", "MESH:D010183", "SCTID:181278006", "TAO:0001372", "VHOG:0000254", "Wikipedia:Pancreatic_duct", "ZFA:0001372" ; oboInOwl:hasExactSynonym "duct of pancreas", "pancreas duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ductus pancreaticus" ; oboInOwl:id "UBERON:0007329" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pancreatic duct" ; rdfs:subClassOf obo:UBERON_0003928, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000017 ], _:genid145797 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png"^^xsd:anyURI . obo:UBERON_0007354 obo:IAO_0000115 "A triangular plate of elastic fibrocartilage that forms the cartilage component of the pharyngotympanic tube." ; oboInOwl:hasDbXref "FMA:60096", "SCTID:362565000", "Wikipedia:Cartilage_of_pharyngotympanic_tube" ; oboInOwl:hasExactSynonym "cartilage of auditory tube", "cartilage of eustachian tube", "cartilago tubae auditivae", "cartilago tubae auditoriae", "pharyngotympanic tube cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilago tubae auditivae; cartilago tubae auditoriae" ; oboInOwl:id "UBERON:0007354" ; a owl:Class ; rdfs:label "cartilage of pharyngotympanic tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray915.png"^^xsd:anyURI . obo:UBERON_0007355 obo:IAO_0000115 "The bony part of pharyngotympanic tube is about 12 mm. in length. It begins in the carotid wall of the tympanic cavity, below the septum canalis musculotubarii, and, gradually narrowing, ends at the angle of junction of the squama and the petrous portion of the temporal bone, its extremity presenting a jagged margin which serves for the attachment of the cartilaginous portion." ; oboInOwl:hasDbXref "FMA:60057", "SCTID:362563007", "Wikipedia:Bony_part_of_pharyngotympanic_tube" ; oboInOwl:hasExactSynonym "bony part of auditory tube", "bony part of eustachian tube", "osseous portion of eustachian tube", "pars ossea (tuba auditiva)", "pars ossea (tuba auditoria)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "osseous portion", "pars ossea tubae auditivae" ; oboInOwl:id "UBERON:0007355" ; a owl:Class ; rdfs:label "bony part of pharyngotympanic tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9d/Gray911.png"^^xsd:anyURI . obo:UBERON_0007367 obo:IAO_0000115 "An anatomical surface that is part of a tongue." ; oboInOwl:hasDbXref "FMA:54647", "SCTID:314870004" ; oboInOwl:hasExactSynonym "tongue surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007367" ; a owl:Class ; rdfs:label "surface of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0007371 obo:IAO_0000115 "The upper (superior) side of the tongue." ; obo:IAO_0000116 "check superior/dorsal" ; oboInOwl:hasDbXref "FMA:54646" ; oboInOwl:hasExactSynonym "dorsal surface of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007371" ; a owl:Class ; rdfs:label "superior surface of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007367 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0007373 obo:IAO_0000115 "The lower (inferior) side of the tongue." ; obo:IAO_0000116 "check inferior/ventral" ; oboInOwl:hasDbXref "FMA:54648", "SCTID:362100003" ; oboInOwl:hasExactSynonym "ventral surface of tongue", "ventrum linguae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007373" ; a owl:Class ; rdfs:label "inferior surface of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007367 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015102 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0007374 obo:IAO_0000115 "An incus endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EMAPA:18228" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007374" ; a owl:Class ; rdfs:label "incus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006248 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015017 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0007375 obo:IAO_0000115 "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones." ; obo:IAO_0000116 "check subclasses to verify if they refer to a multi-tissue structure or a subdivision of the skeleton" ; oboInOwl:hasDbXref "CALOHA:TS-2212", "Wikipedia:Palate" ; oboInOwl:hasExactSynonym "roof of buccal cavity", "roof of oral cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palate", "palatum", "primary or secondary palate" ; oboInOwl:id "UBERON:0007375" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "roof of mouth" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] . obo:UBERON_0007376 obo:IAO_0000115 "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." ; obo:IAO_0000116 "this grouping class exists primarily to align with GO - see GO:0008544." ; oboInOwl:hasDbXref "BSA:0000073", "BTO:0000313", "FBbt:00004993", "HAO:0000298", "TADS:0000109", "WBbt:0005733", "Wikipedia:Epidermis_(zoology)" ; oboInOwl:hasExactSynonym "epidermis", "epidermis (sensu Metazoa)", "outer epidermal layer", "outer epithelial layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hypoderm", "hypodermis" ; oboInOwl:id "UBERON:0007376" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "outer epithelium" ; rdfs:subClassOf obo:UBERON_0003102 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000468 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007383 ] ) ] . obo:UBERON_0007383 obo:IAO_0000115 "Outermost layer of cells surrounding the embryo." ; obo:UBPROP_0000001 "Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO]" ; obo:UBPROP_0000002 "relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO]" ; obo:UBPROP_0000008 "Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm." ; oboInOwl:hasDbXref "EFO:0003425", "TAO:0000086", "ZFA:0000086" ; oboInOwl:hasExactSynonym "EVL", "enveloping layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007383" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "enveloping layer of ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 ] . obo:UBERON_0007384 obo:IAO_0000115 "A lymphatic vessel that is part of a limb/fin." ; oboInOwl:hasDbXref "TAO:0005300", "ZFA:0005300" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007384" ; a owl:Class ; rdfs:label "appendage lymph vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007304 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004708 ] ) ] . obo:UBERON_0007385 obo:IAO_0000115 "A lymphatic vessel that is part of a pectoral appendage." ; oboInOwl:hasDbXref "TAO:0005302", "ZFA:0005302" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007385" ; a owl:Class ; rdfs:label "pectoral appendage lymph vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007302 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0007386 obo:IAO_0000115 "A lymphatic vessel that is part of a pelvic appendage." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007386" ; a owl:Class ; rdfs:label "pelvic appendage lymph vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0007389 obo:IAO_0000115 "A cartilage tissue that is part of a paired limb or fin." ; obo:UBPROP_0000001 "Cartilage which is part of one of the paired fins.[TAO]" ; oboInOwl:hasDbXref "TAO:0001543", "ZFA:0001543" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007389" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "paired limb/fin cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ] ; owl:equivalentClass _:genid144289 . obo:UBERON_0007390 obo:IAO_0000115 "A cartilage tissue that is part of a pectoral appendage." ; obo:UBPROP_0000001 "Cartilage which is part of the pectoral fin.[TAO]" ; oboInOwl:hasDbXref "TAO:0000257", "ZFA:0000257" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pectoral fin cartilage" ; oboInOwl:id "UBERON:0007390" ; a owl:Class ; rdfs:label "pectoral appendage cartilage tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007272 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0007391 obo:IAO_0000115 "A cartilage tissue that is part of a pelvic appendage." ; obo:UBPROP_0000001 "Cartilage which is part of the pelvic fin.[TAO]" ; oboInOwl:hasDbXref "TAO:0001459", "ZFA:0001459" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic fin cartilage" ; oboInOwl:id "UBERON:0007391" ; a owl:Class ; rdfs:label "pelvic appendage cartilage tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007273 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0007414 obo:IAO_0000115 "A nucleus of brain that spans a midbrain tegmentum." ; obo:IAO_0000232 "this class groups together any nuclei in the tegmentum region, possibly including disparate structures across species" ; oboInOwl:hasAlternativeId "UBERON:0012277" ; oboInOwl:hasDbXref "FMA:258768", "ZFA:0005577" ; oboInOwl:hasExactSynonym "tegmental nuclei", "tegmental nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007414" ; a owl:Class ; rdfs:label "nucleus of midbrain tegmentum" ; owl:equivalentClass _:genid144312 . obo:UBERON_0007416 obo:IAO_0000115 "Any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem." ; oboInOwl:hasDbXref "BAMS:cbp", "EMAPA:35213", "FMA:272298", "MA:0002742", "MBA:752", "NCIT:C88147", "SCTID:362417003", "UMLS:C0228515", "neuronames:1207" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebellum peduncle" ; oboInOwl:id "UBERON:0007416" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cerebellar peduncle" ; rdfs:subClassOf obo:UBERON_0007417, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002474 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002317 ] . obo:UBERON_0007417 oboInOwl:hasDbXref "FMA:83860" ; oboInOwl:hasExactSynonym "neuraxis peduncle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007417" ; a owl:Class ; rdfs:label "peduncle of neuraxis" ; rdfs:subClassOf obo:UBERON_0002316 . obo:UBERON_0007418 obo:IAO_0000115 "Nerve fibers crossing the midline of the neuraxis relative to their point of origin, on a course to from one level of the nervous system to another. (CUMBO, Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)." ; oboInOwl:hasBroadSynonym "chiasm", "chiasma", "decussation" ; oboInOwl:hasDbXref "FMA:83858", "NCIT:C28351", "NLX:144064" ; oboInOwl:hasExactSynonym "decussation of neuraxis", "neuraxis chiasm", "neuraxis chiasma", "neuraxis decussation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007418" ; oboInOwl:inSubset core:cumbo ; a owl:Class ; rdfs:label "neural decussation" ; rdfs:subClassOf obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 ] . obo:UBERON_0007425 obo:IAO_0000115 "A neural decussation that is part of a diencephalon." ; oboInOwl:hasDbXref "FMA:62446" ; oboInOwl:hasExactSynonym "diencephalon decussation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007425" ; a owl:Class ; rdfs:label "decussation of diencephalon" ; rdfs:subClassOf obo:UBERON_0007418, _:genid145938 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007418 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0007473 obo:IAO_0000115 "The space within an epithelial sphere." ; oboInOwl:hasDbXref "AEO:0000079" ; oboInOwl:hasExactSynonym "cavity of vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007473" ; a owl:Class ; rdfs:label "lumen of epithelial sac" ; rdfs:subClassOf _:genid144342 ; owl:equivalentClass _:genid144338 . obo:UBERON_0007475 obo:IAO_0000115 "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." ; oboInOwl:hasDbXref "AEO:0000081", "EHDAA2:0003081" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007475" ; a owl:Class ; rdfs:label "matrix-based tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0031012 ] ) ] . obo:UBERON_0007490 obo:IAO_0000115 "Acellular anatomical structure whose predominant constituent is keratin." ; obo:IAO_0000116 "should all structures composed primarily of keratin be classified here? At what stage of cornification are keratin-filled cells no longer considered cells" ; oboInOwl:hasDbXref "AEO:0000099", "EHDAA2:0003099" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "keratin-based structure" ; oboInOwl:id "UBERON:0007490" ; a owl:Class ; rdfs:label "keratin-based acellular structure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002507 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000476 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0045095 ] ) ] . obo:UBERON_0007499 obo:IAO_0000115 "An epithelial tube that is open at one end only." ; oboInOwl:hasDbXref "AEO:0000115", "EHDAA2:0003115" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007499" ; a owl:Class ; rdfs:label "epithelial sac" ; rdfs:subClassOf obo:UBERON_0003914 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001987 ] ) ] . obo:UBERON_0007500 obo:IAO_0000115 "An epithelial tube open at both ends that allows fluid flow." ; oboInOwl:hasDbXref "AEO_RETIRED:0000116", "RETIRED_EHDAA2:0003116" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007500" ; a owl:Class ; rdfs:label "epithelial tube open at both ends" ; rdfs:subClassOf obo:UBERON_0003914 . obo:UBERON_0007501 obo:IAO_0000115 "A collection of connected epithelial tubes with a single portal." ; oboInOwl:hasDbXref "AEO:0000117", "EHDAA2:0003117" ; oboInOwl:hasExactSynonym "arborising epithelial duct system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007501" ; a owl:Class ; rdfs:label "arborizing epithelial duct system" ; rdfs:subClassOf obo:UBERON_0007499, _:genid145970 . obo:UBERON_0007503 obo:IAO_0000115 "A closed epithelium with a lumen." ; oboInOwl:hasDbXref "AEO:0000119", "EHDAA2:0003119" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007503" ; a owl:Class ; rdfs:label "epithelial vesicle" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0007521 obo:IAO_0000115 "A ring of smooth muscle cells whose contraction closes the opening of the ring." ; oboInOwl:hasDbXref "AEO:0000143", "EHDAA2:0003143", "SCTID:362915001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007521" ; a owl:Class ; rdfs:label "smooth muscle sphincter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001135 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000192 ] ) ] . obo:UBERON_0007522 obo:IAO_0000115 "A ring of striated muscle cells whose contraction closes the opening of the ring." ; oboInOwl:hasDbXref "AEO:0000144", "EHDAA2:0003144" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007522" ; a owl:Class ; rdfs:label "striated muscle sphincter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002036 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000737 ] ) ] . obo:UBERON_0007524 obo:IAO_0000115 "Mesenchyme with little extracellular matrix." ; oboInOwl:hasDbXref "AEO:0000146", "EHDAA2:0003146" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007524" ; a owl:Class ; rdfs:label "dense mesenchyme tissue" ; rdfs:subClassOf obo:UBERON_0003104, _:genid145989 . obo:UBERON_0007529 obo:IAO_0000115 "Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix." ; oboInOwl:hasDbXref "AEO:0000151", "EHDAA2:0003151" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007529" ; a owl:Class ; rdfs:label "loose mesenchyme tissue" ; rdfs:subClassOf obo:UBERON_0003104, _:genid145993, _:genid145995 . obo:UBERON_0007530 obo:IAO_0000115 "Mesenchymal cells that are migrating." ; obo:IAO_0000116 "this class will be an important part of the NC reorganization" ; oboInOwl:hasDbXref "AEO:0000152", "EHDAA2:0003152" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007530" ; a owl:Class ; rdfs:label "migrating mesenchyme population" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0016477 ] ) ] . obo:UBERON_0007567 obo:IAO_0000115 "An anatomical structure that is undergoing regeneration." ; obo:IAO_0000116 "we define this in terms of active participation in regeneration, rather that capabilities. In this sense it is different from the AEO structure." ; obo:UBPROP_0000001 "A portion of tissue that is regrowing after damage or amputation.[TAO]" ; oboInOwl:hasDbXref "AEO:0000200", "EHDAA2:0003233", "TAO:0005147", "XAO:0004059", "ZFA:0005147" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "regenerating tissue", "regenerating tissues", "regenerative tissue" ; oboInOwl:id "UBERON:0007567" ; a owl:Class ; rdfs:label "regenerating anatomical structure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0031099 ] ) ] . obo:UBERON_0007589 obo:IAO_0000115 "A ciliated columnar epithelium that is part of a oviduct." ; obo:UBPROP_0000012 "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" ; oboInOwl:hasDbXref "FMA:62016", "MA:0001719" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium of uterine tube", "uterine tube epithelium" ; oboInOwl:id "UBERON:0007589" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ciliated columnar oviduct epithelium" ; rdfs:subClassOf obo:UBERON_0004804, obo:UBERON_0007592 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007592 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:UBERON_0007590 obo:IAO_0000115 "A cuboidal epithelium that is part of a oviduct." ; oboInOwl:hasDbXref "MA:0001720" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007590" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cuboidal oviduct epithelium" ; rdfs:subClassOf obo:UBERON_0004804 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:UBERON_0007592 obo:IAO_0000115 "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]." ; obo:UBPROP_0000008 "In humans, Ciliated columnar epithelial cells are found mainly in the tracheal and bronchial regions of the pulmonary system and also in the fallopian tubes of the female reproductive system" ; obo:UBPROP_0000009 "Ciliated columnar epithelium in the pulmonary system is interspersed with goblet cells that secrete mucous to form a mucosal layer apical to the epithelial layer. The rowing-like action of epithelial cilia work in tandem with goblet cells to propel mucus away from the lungs, preventing particulate matter from causing infection[http://www.bio.davidson.edu/people/kabernd/berndcv/lab/epithelialinfoweb/ciliated%20columnar%20epithelium.html]" ; oboInOwl:hasDbXref "FMA:64798" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007592" ; a owl:Class ; rdfs:label "ciliated columnar epithelium" ; rdfs:subClassOf obo:UBERON_0000485 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000485 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000067 ] ) ] . obo:UBERON_0007601 obo:IAO_0000115 "Epithelium bearing vibratile cilia on the free surface." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007601" ; a owl:Class ; rdfs:label "ciliated epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid144427 ] . obo:UBERON_0007602 obo:IAO_0000115 "Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP]." ; oboInOwl:hasDbXref "FMA:45564", "NCIT:C33620", "UMLS:C0836132", "Wikipedia:Stratified_columnar_epithelia" ; oboInOwl:hasExactSynonym "epithelium stratificatum columnare" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007602" ; a owl:Class ; rdfs:label "stratified columnar epithelium" ; rdfs:subClassOf obo:UBERON_0000486, obo:UBERON_0012274 . obo:UBERON_0007606 oboInOwl:hasDbXref "FMA:67521" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007606" ; a owl:Class ; rdfs:label "ciliated stratified columnar epithelium" ; rdfs:subClassOf obo:UBERON_0007602 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007602 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000067 ] ) ] . obo:UBERON_0007610 obo:IAO_0000115 "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot." ; oboInOwl:hasDbXref "EMAPA:36530", "GAID:514", "MA:0002067", "MESH:D016909", "NCIT:C12824", "SCTID:181351007", "UMLS:C0085427" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007610" ; a owl:Class ; rdfs:label "tibial artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002250 ] . obo:UBERON_0007616 obo:IAO_0000115 "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." ; oboInOwl:hasDbXref "BTO:0001338", "CALOHA:TS-0998", "FMA:66762" ; oboInOwl:hasExactSynonym "synovium" ; oboInOwl:hasNarrowSynonym "stratum synoviale", "synovial layer", "synovial membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "synovial tissue" ; oboInOwl:id "UBERON:0007616" ; a owl:Class ; rdfs:label "layer of synovial tissue" ; rdfs:subClassOf _:genid146057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001090 ] ) ] . obo:UBERON_0007617 obo:IAO_0000115 "An anatomical cavity that surrounded_by a synovial joint." ; oboInOwl:hasDbXref "FMA:11356" ; oboInOwl:hasExactSynonym "articular cavity (synovial joint)", "cavitas articularis (junctura synovialis)", "cavity of synovial joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "joint cavity", "synovial cavity" ; oboInOwl:id "UBERON:0007617" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "synovial cavity of joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002217 ] ) ] . obo:UBERON_0007618 obo:IAO_0000115 "A synovial cavity of joint that is part of a hip joint." ; oboInOwl:hasDbXref "EMAPA:19021", "FMA:9701" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007618" ; a owl:Class ; rdfs:label "synovial cavity of hip joint" ; rdfs:subClassOf _:genid146079 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007617 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001486 ] ) ] . obo:UBERON_0007619 obo:UBPROP_0000012 "MA does treat internal/external limiting membranes as layers - these are classified as laminae. We do not follow this convention. However, we do following MA is grouping these terms together" ; oboInOwl:hasDbXref "MA:0001318", "SCTID:280667001" ; oboInOwl:hasExactSynonym "retina lamina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007619" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "limiting membrane of retina" ; rdfs:subClassOf obo:UBERON_0001781, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 ] . obo:UBERON_0007625 obo:IAO_0000115 "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." ; oboInOwl:hasDbXref "GAID:907", "MESH:D010857" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye pigment epithelium" ; oboInOwl:id "UBERON:0007625" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pigment epithelium of eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000970 ] ) ] . obo:UBERON_0007635 obo:IAO_0000115 "A neural nucleus that is part of a medulla oblongata." ; oboInOwl:hasDbXref "FMA:258772", "SCTID:304943004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007635" ; a owl:Class ; rdfs:label "nucleus of medulla oblongata" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] ) ] . obo:UBERON_0007641 obo:IAO_0000115 "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]." ; obo:UBPROP_0000012 "in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate." ; oboInOwl:hasDbXref "BIRNLEX:4096", "BM:V", "CALOHA:TS-2077", "DHBA:266441713", "FMA:71248", "HBA:9203", "UMLS:C0040999", "Wikipedia:Trigeminal_nerve_nuclei", "neuronames:2021" ; oboInOwl:hasExactSynonym "trigeminal nuclei" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclei trigemini" ; oboInOwl:id "UBERON:0007641" ; a owl:Class ; rdfs:label "trigeminal nuclear complex" ; rdfs:subClassOf obo:UBERON_0007245, [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001645 ], _:genid146098 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png"^^xsd:anyURI . obo:UBERON_0007644 obo:IAO_0000115 "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes." ; oboInOwl:hasDbXref "FMA:12772", "NCIT:C33769", "SCTID:196374005", "UMLS:C0229745", "Wikipedia:Lymph_node#Lymph_nodes_of_the_thorax" ; oboInOwl:hasExactSynonym "lymph node of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deep thoracic lymph node" ; oboInOwl:id "UBERON:0007644" ; a owl:Class ; rdfs:label "thoracic lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0007645 obo:IAO_0000115 "A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx." ; obo:IAO_0000116 "decide whether to treat the endo and ecto meninx as subtypes or parts of the future meninx" ; obo:UBPROP_0000001 "the outermost mesenchymal covering of the developing brain and spinal cord that is composed of tough fibrous connective tissue from which the arachnoid mater, pia mater and dura mater are formed[MP:0009726]d" ; oboInOwl:hasAlternativeId "UBERON:0004065" ; oboInOwl:hasDbXref "EHDAA2:0004453" ; oboInOwl:hasExactSynonym "primary meninx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "meninx primitiva", "primitive meninx", "primordial meninx" ; oboInOwl:id "UBERON:0007645" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "future meninx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid146119, _:genid146121 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002360 ] ) ] . obo:UBERON_0007646 obo:IAO_0000115 "The innermost layer of the mesenchymal capsule that surrounds the developing brain, primarily of neural crest origin. The endomeninx forms the leptomeninx." ; oboInOwl:hasExactSynonym "future leptomeninges", "future leptomeninx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007646" ; a owl:Class ; rdfs:label "endomeninx" ; rdfs:subClassOf obo:UBERON_0007645, _:genid146131 ; owl:equivalentClass _:genid144514 . obo:UBERON_0007647 obo:IAO_0000115 "The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer)." ; oboInOwl:hasAlternativeId "UBERON:0010115" ; oboInOwl:hasDbXref "EHDAA2:0004317" ; oboInOwl:hasExactSynonym "future dura mater" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007647" ; a owl:Class ; rdfs:label "ectomeninx" ; rdfs:subClassOf _:genid146138, _:genid146140 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007645 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002363 ] ) ] . obo:UBERON_0007651 obo:IAO_0000115 "An anatomical structure that connects two structures." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasBroadSynonym "junction" ; oboInOwl:hasDbXref "FMA:5898", "SCTID:91833003" ; oboInOwl:hasExactSynonym "anatomical junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007651" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "anatomical junction" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:UBERON_0000061 ; owl:onProperty obo:RO_0002176 ] . obo:UBERON_0007652 obo:IAO_0000115 "A sphincter that is part of an esophagus." ; obo:IAO_0000116 "check for specific subtypes across species. Note mammals have upper and lower, but lower is really part of cardia and thus is not classified under here" ; oboInOwl:hasDbXref "SCTID:277765007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007652" ; a owl:Class ; rdfs:label "esophageal sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0007684 obo:IAO_0000115 "Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." ; oboInOwl:hasDbXref "FMA:17691" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007684" ; a owl:Class ; rdfs:label "uriniferous tubule" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001232 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001285 ], _:genid146152 . obo:UBERON_0007687 obo:IAO_0000115 "Region of the embryo into the area in which the kidney rudiment will develop." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney anlage" ; oboInOwl:id "UBERON:0007687" ; a owl:Class ; rdfs:label "kidney field" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007688 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0007688 obo:IAO_0000115 "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." ; oboInOwl:hasBroadSynonym "field" ; oboInOwl:hasDbXref "AEO:0000170", "EFO:0001649", "EHDAA2:0003170", "FBbt:00005426", "Wikipedia:Anlage_(biology)" ; oboInOwl:hasExactSynonym "developmental field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future organ", "organ field" ; oboInOwl:id "UBERON:0007688" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "anlage" ; rdfs:subClassOf obo:UBERON_0000479, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] . obo:UBERON_0007689 obo:IAO_0000115 "Endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP]." ; oboInOwl:hasDbXref "Wikipedia:Thyroid_diverticulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diverticulum thyroideum", "saccus thyroideus" ; oboInOwl:id "UBERON:0007689" ; a owl:Class ; rdfs:label "thyroid diverticulum" ; rdfs:subClassOf obo:UBERON_0001048, [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003091 ], _:genid146168 . obo:UBERON_0007690 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "EFO:0003626", "EHDAA2:0001457", "EHDAA:962", "EMAPA:32754", "FMA:293087", "TAO:0001104", "ZFA:0001104" ; oboInOwl:hasExactSynonym "early pharyngeal arch endoderm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngeal arch endoderm", "pharyngeal endoderm", "pharyngeal region endoderm" ; oboInOwl:id "UBERON:0007690" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm'" ; rdfs:label "early pharyngeal endoderm" ; rdfs:subClassOf obo:UBERON_0000490, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008814 ], _:genid146176, _:genid146178 . obo:UBERON_0007691 obo:IAO_0000115 "The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project." ; oboInOwl:hasDbXref "FMA:63589", "NCIT:C33738", "SCTID:368724008", "UMLS:C0226971" ; oboInOwl:hasExactSynonym "porus gustatorius", "taste pore" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007691" ; a owl:Class ; rdfs:label "gustatory pore" ; rdfs:subClassOf obo:UBERON_0000161, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000167 ], _:genid146189 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001727 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/0e/Taste_bud.svg"^^xsd:anyURI . obo:UBERON_0007692 obo:IAO_0000115 "A nucleus of brain that is part of a thalamus." ; obo:IAO_0000116 "TODO - consider splitting nucleus and complex" ; oboInOwl:hasDbXref "BTO:0002452", "EMAPA:35859", "FMA:256693", "MA:0002992", "SCTID:279115000", "Wikipedia:List_of_thalamic_nuclei" ; oboInOwl:hasExactSynonym "thalamic nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nuclear complex of thalamus" ; oboInOwl:id "UBERON:0007692" ; a owl:Class ; rdfs:label "nucleus of thalamus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001897 ] ) ] . obo:UBERON_0007699 obo:IAO_0000115 "An axon tract that is part of a spinal cord." ; oboInOwl:hasDbXref "FMA:75683", "NCIT:C12995", "UMLS:C1519456" ; oboInOwl:hasExactSynonym "spinal cord tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007699" ; a owl:Class ; rdfs:label "tract of spinal cord" ; rdfs:subClassOf _:genid146207 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0007702 obo:IAO_0000115 "An axon tract that is part of a brain." ; obo:IAO_0000116 "the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts" ; oboInOwl:hasDbXref "FMA:83848" ; oboInOwl:hasExactSynonym "brain tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "landmark tracts" ; oboInOwl:id "UBERON:0007702" ; a owl:Class ; rdfs:label "tract of brain" ; rdfs:subClassOf _:genid146216 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid144591 ] . obo:UBERON_0007709 obo:UBPROP_0000012 "FMA:72495 most likely denotes this class rather than the more generic parent, due to the part of relationship to pontine tegmentum." ; oboInOwl:hasBroadSynonym "SCPP" ; oboInOwl:hasDbXref "BAMS:scpp", "BIRNLEX:1726", "FMA:72495", "neuronames:1007150190", "neuronames:833" ; oboInOwl:hasExactSynonym "SCPP", "superior cerebellar peduncle of pons" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedunculus cerebellaris superior (pontis)", "superior cerebellar peduncle of the pons" ; oboInOwl:id "UBERON:0007709" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "superior cerebellar peduncle of pons" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002150 ], _:genid146222 . obo:UBERON_0007719 obo:IAO_0000115 "A bone that is part of a reproductive organ." ; oboInOwl:hasNarrowSynonym "baculum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os penis/os clitoris" ; oboInOwl:id "UBERON:0007719" ; a owl:Class ; rdfs:label "bone of reproductive organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003133 ] ) ] . obo:UBERON_0007721 obo:IAO_0000115 "The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments." ; oboInOwl:hasDbXref "EMAPA:36337", "FMA:35225", "MESH:D014033", "NCIT:C32867", "NCIT:C33789", "SCTID:182225005", "UMLS:C0040356", "Wikipedia:Interphalangeal_articulations_of_the_foot" ; oboInOwl:hasExactSynonym "foot interphalangeal joint", "hindlimb digit inter-phalangeal joint", "interphalangeal joint of foot" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "toe joint" ; oboInOwl:id "UBERON:0007721" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interphalangeal joint of pes" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0001449 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ], _:genid146240 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006658 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0007722 obo:IAO_0000115 "The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes." ; obo:IAO_0000116 "consider renaming: 'finger' is ambiguous as the term in some usages excludes the thumb (we include it)" ; oboInOwl:hasDbXref "EMAPA:36336", "FMA:35285", "NCIT:C32868", "SCTID:303280009", "UMLS:C0016125", "Wikipedia:Interphalangeal_articulations_of_the_hand" ; oboInOwl:hasExactSynonym "articulationes digitorum manus", "articulationes interphalangeae manus", "interphalangeal joint of hand" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "IP joint", "articulations of the digits", "interphalangeal articulations of hand", "interphalangeal joints of hand" ; oboInOwl:id "UBERON:0007722" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interphalangeal joint of manus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0001436 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ], _:genid146254 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006658 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0007723 obo:IAO_0000115 "An interphalangeal joint of manus that is part of a manual digit 1." ; obo:UBPROP_0000008 "in humans, this connects proximal and distal phalanges of the thumb, so there is only a single inter-phalangeal joint - i.e. there is no distinct proximal and distal joints" ; oboInOwl:hasDbXref "EMAPA:25058", "FMA:35312", "NCIT:C102306", "SCTID:182192008" ; oboInOwl:hasExactSynonym "interphalangeal joint of first digit of hand", "interphalangeal joint of hand digit 1", "interphalangeal joint of manual digit 1", "interphalangeal joint of manual digit I", "interphalangeal joint of pollex" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007723" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interphalangeal joint of manual digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003620 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007722 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0007724 obo:IAO_0000115 "An interphalangeal joint of pes that is part of a pedal digit 1." ; oboInOwl:hasDbXref "EMAPA:26430", "FMA:35353", "SCTID:363671008" ; oboInOwl:hasExactSynonym "interphalangeal joint of first digit of foot", "interphalangeal joint of first digit of pes", "interphalangeal joint of foot digit 1", "interphalangeal joint of great toe", "interphalangeal joint of hallux", "interphalangeal joint of pedal digit 1", "interphalangeal joint of pedal digit I" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of big toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interphalangeal joint of first toe" ; oboInOwl:id "UBERON:0007724" ; a owl:Class ; rdfs:label "interphalangeal joint of pedal digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003640 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0007725 obo:IAO_0000115 "An interphalangeal joint of pes that is part of a pedal digit 2." ; oboInOwl:hasDbXref "EMAPA:26448", "FMA:35356" ; oboInOwl:hasExactSynonym "interphalangeal joint of pedal digit II", "interphalangeal joint of second digit of foot" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of second toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007725" ; a owl:Class ; rdfs:label "interphalangeal joint of pedal digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003641 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0007726 obo:IAO_0000115 "An interphalangeal joint of pes that is part of a pedal digit 3." ; oboInOwl:hasDbXref "EMAPA:26454", "FMA:35359" ; oboInOwl:hasExactSynonym "interphalangeal joint of pedal digit III", "interphalangeal joint of third digit of foot" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of third toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007726" ; a owl:Class ; rdfs:label "interphalangeal joint of pedal digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003642 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0007727 obo:IAO_0000115 "An interphalangeal joint of pes that is part of a pedal digit 4." ; oboInOwl:hasDbXref "EMAPA:26466", "FMA:35362" ; oboInOwl:hasExactSynonym "interphalangeal joint of fourth digit of foot", "interphalangeal joint of pedal digit IV" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of fourth toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007727" ; a owl:Class ; rdfs:label "interphalangeal joint of pedal digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003862 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0007728 obo:IAO_0000115 "An interphalangeal joint of pes that is part of a pedal digit 5." ; oboInOwl:hasDbXref "EMAPA:26478", "FMA:35365" ; oboInOwl:hasExactSynonym "interphalangeal joint of fifth digit of foot", "interphalangeal joint of fifth toe", "interphalangeal joint of pedal digit V" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of little toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007728" ; a owl:Class ; rdfs:label "interphalangeal joint of pedal digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003863 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid144690 ] . obo:UBERON_0007729 obo:IAO_0000115 "An interphalangeal joint of manus that is part of a manual digit 2." ; oboInOwl:hasDbXref "EMAPA:25061", "FMA:35397" ; oboInOwl:hasExactSynonym "interphalangeal joint of manual digit II", "interphalangeal joint of second digit of hand", "interphalangeal joint of second finger" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007729" ; a owl:Class ; rdfs:label "interphalangeal joint of manual digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003641 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ], _:genid146329 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007722 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0007730 obo:IAO_0000115 "An interphalangeal joint of manus that is part of a manual digit 3." ; oboInOwl:hasDbXref "EMAPA:25064", "FMA:35400" ; oboInOwl:hasExactSynonym "interphalangeal joint of manual digit III", "interphalangeal joint of third digit of hand", "interphalangeal joint of third finger" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007730" ; a owl:Class ; rdfs:label "interphalangeal joint of manual digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003642 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007722 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0007731 obo:IAO_0000115 "An interphalangeal joint of manus that is part of a manual digit 4." ; oboInOwl:hasDbXref "EMAPA:25067", "FMA:35403" ; oboInOwl:hasExactSynonym "interphalangeal joint of fourth digit of hand", "interphalangeal joint of fourth finger", "interphalangeal joint of manual digit IV" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007731" ; a owl:Class ; rdfs:label "interphalangeal joint of manual digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003862 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007722 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0007732 obo:IAO_0000115 "An interphalangeal joint of manus that is part of a manual digit 5." ; oboInOwl:hasDbXref "EMAPA:25070", "FMA:35407" ; oboInOwl:hasExactSynonym "interphalangeal joint of fifth digit of hand", "interphalangeal joint of fifth finger", "interphalangeal joint of manual digit V" ; oboInOwl:hasNarrowSynonym "interphalangeal joint of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007732" ; a owl:Class ; rdfs:label "interphalangeal joint of manual digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onClass obo:UBERON_0003863 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007722 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0007735 obo:IAO_0000115 "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 1." ; oboInOwl:hasDbXref "EMAPA:25057", "FMA:35249", "SCTID:361844001" ; oboInOwl:hasExactSynonym "metacarpophalangeal joint of digit 1", "metacarpophalangeal joint of first digit of hand", "metacarpophalangeal joint of manual digit I" ; oboInOwl:hasNarrowSynonym "metacarpo-phalangeal joint of digit 1 of fore-paw", "metacarpophalangeal joint of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007735" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpophalangeal joint of manual digit 1" ; rdfs:subClassOf _:genid146373 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004338 ] ) ] . obo:UBERON_0007738 obo:IAO_0000115 "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 2." ; oboInOwl:hasDbXref "EMAPA:25060", "FMA:35252", "SCTID:361845000" ; oboInOwl:hasExactSynonym "metacarpophalangeal joint of digit 2", "metacarpophalangeal joint of manual digit II", "metacarpophalangeal joint of second digit of hand", "metacarpophalangeal joint of second finger" ; oboInOwl:hasNarrowSynonym "metacarpo-phalangeal joint of digit 2 of fore-paw", "metacarpophalangeal joint of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007738" ; a owl:Class ; rdfs:label "metacarpophalangeal joint of manual digit 2" ; rdfs:subClassOf _:genid146386 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] _:genid144756 ) ] . obo:UBERON_0007741 obo:IAO_0000115 "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 3." ; oboInOwl:hasDbXref "EMAPA:25063", "FMA:35255", "SCTID:361846004" ; oboInOwl:hasExactSynonym "metacarpophalangeal joint of digit 3", "metacarpophalangeal joint of manual digit III", "metacarpophalangeal joint of third digit of hand", "metacarpophalangeal joint of third finger" ; oboInOwl:hasNarrowSynonym "carpometacarpophalangeal joint of third digit", "metacarpo-phalangeal joint of digit 3 of fore-paw", "metacarpophalangeal joint of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007741" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpophalangeal joint of manual digit 3" ; rdfs:subClassOf _:genid146400 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004329 ] ) ] . obo:UBERON_0007744 obo:IAO_0000115 "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 4." ; oboInOwl:hasDbXref "EMAPA:25066", "FMA:35258", "SCTID:361847008" ; oboInOwl:hasExactSynonym "metacarpophalangeal joint of digit 4", "metacarpophalangeal joint of fourth digit of hand", "metacarpophalangeal joint of fourth finger", "metacarpophalangeal joint of manual digit IV" ; oboInOwl:hasNarrowSynonym "carpometacarpophalangeal joint of fourth digit", "metacarpo-phalangeal joint of digit 4 of fore-paw", "metacarpophalangeal joint of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007744" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpophalangeal joint of manual digit 4" ; rdfs:subClassOf _:genid146415 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004330 ] ) ] . obo:UBERON_0007747 obo:IAO_0000115 "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 5." ; oboInOwl:hasDbXref "EMAPA:25069", "FMA:35261", "SCTID:361848003" ; oboInOwl:hasExactSynonym "metacarpophalangeal joint of digit 5", "metacarpophalangeal joint of fifth digit of hand", "metacarpophalangeal joint of fifth finger", "metacarpophalangeal joint of manual digit V" ; oboInOwl:hasNarrowSynonym "metacarpo-phalangeal joint of digit 5 of fore-paw", "metacarpophalangeal joint of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007747" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metacarpophalangeal joint of manual digit 5" ; rdfs:subClassOf _:genid146430 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004331 ] ) ] . obo:UBERON_0007750 obo:IAO_0000115 "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 1." ; obo:UBPROP_0000012 "the name of the structure in EMAPA is incorrect" ; oboInOwl:hasDbXref "EMAPA:26436", "FMA:35228", "NCIT:C102321", "SCTID:182223003" ; oboInOwl:hasExactSynonym "first metatarsophalangeal joint", "metatarsophalangeal joint of first digit of foot", "metatarsophalangeal joint of great toe", "metatarsophalangeal joint of pedal digit I" ; oboInOwl:hasNarrowSynonym "metatarsophalangeal joint of big toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsophalangeal joint of first toe" ; oboInOwl:id "UBERON:0007750" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metatarsophalangeal joint of pedal digit 1" ; rdfs:subClassOf _:genid146444 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] . obo:UBERON_0007753 obo:IAO_0000115 "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 2." ; obo:UBPROP_0000012 "the name of the structure in EMAPA is incorrect" ; oboInOwl:hasDbXref "EMAPA:26442", "FMA:35231", "SCTID:361869001" ; oboInOwl:hasExactSynonym "metatarsophalangeal joint of pedal digit II", "metatarsophalangeal joint of second digit of foot" ; oboInOwl:hasNarrowSynonym "metatarsophalangeal joint of second toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007753" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metatarsophalangeal joint of pedal digit 2" ; rdfs:subClassOf _:genid146459 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] . obo:UBERON_0007756 obo:IAO_0000115 "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 3." ; obo:UBPROP_0000012 "the name of the structure in EMAPA is incorrect" ; oboInOwl:hasDbXref "EMAPA:26460", "FMA:35234", "SCTID:361870000" ; oboInOwl:hasExactSynonym "metatarsophalangeal joint of pedal digit III", "metatarsophalangeal joint of third digit of foot" ; oboInOwl:hasNarrowSynonym "metatarsophalangeal joint of third toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007756" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metatarsophalangeal joint of pedal digit 3" ; rdfs:subClassOf _:genid146472 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] . obo:UBERON_0007759 obo:IAO_0000115 "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 4." ; obo:UBPROP_0000012 "the name of the structure in EMAPA is incorrect" ; oboInOwl:hasDbXref "EMAPA:26472", "FMA:35237", "SCTID:361871001" ; oboInOwl:hasExactSynonym "metatarsophalangeal joint of fourth digit of foot", "metatarsophalangeal joint of pedal digit IV" ; oboInOwl:hasNarrowSynonym "metatarsophalangeal joint of fourth toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007759" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metatarsophalangeal joint of pedal digit 4" ; rdfs:subClassOf _:genid146485 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] . obo:UBERON_0007762 obo:IAO_0000115 "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 5." ; obo:UBPROP_0000012 "the name of the structure in EMAPA is incorrect" ; oboInOwl:hasDbXref "EMAPA:26484", "FMA:35240", "SCTID:361872008" ; oboInOwl:hasExactSynonym "metatarsophalangeal joint of fifth digit of foot", "metatarsophalangeal joint of fifth toe", "metatarsophalangeal joint of pedal digit V" ; oboInOwl:hasNarrowSynonym "metatarsophalangeal joint of little toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007762" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metatarsophalangeal joint of pedal digit 5" ; rdfs:subClassOf _:genid146498 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] . obo:UBERON_0007771 obo:IAO_0000115 "A gland that is part of a epidermis." ; oboInOwl:hasDbXref "FMA:59153" ; oboInOwl:hasExactSynonym "epidermal gland", "gland of epidermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007771" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "epidermis gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] ) ] . obo:UBERON_0007772 obo:IAO_0000115 "Any portion of sweat that is produced by a sweat gland of the scrotum." ; oboInOwl:hasDbXref "FMA:73266" ; oboInOwl:hasExactSynonym "scrotum sweat", "sweat of scrotal sac", "sweat of scrotum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007772" ; a owl:Class ; rdfs:label "scrotal sweat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001089 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0007773 ] ) ] . obo:UBERON_0007773 obo:IAO_0000115 "Any sweat gland that is part of a scrotum." ; oboInOwl:hasDbXref "EMAPA:29743" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007773" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "scrotal sweat gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ] ) ] . obo:UBERON_0007774 obo:IAO_0000115 "The teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed)." ; oboInOwl:hasDbXref "FMA:75152", "GAID:1251", "MESH:D019229" ; oboInOwl:hasExactSynonym "dentes permanentes", "permanent dentition", "permanent teeth", "set of permanent teeth", "set of secondary teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adult dentition", "secondary dentition" ; oboInOwl:id "UBERON:0007774" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "secondary dentition" ; rdfs:subClassOf obo:UBERON_0003672 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003672 [ a owl:Restriction ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0007775 obo:IAO_0000115 "A tooth that forms after a primary tooth." ; oboInOwl:hasDbXref "FMA:55654", "NCIT:C33313", "SCTID:245563006", "UMLS:C0348070", "Wikipedia:Permanent_teeth" ; oboInOwl:hasExactSynonym "permanent tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dentes permanentes" ; oboInOwl:id "UBERON:0007775" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "GAT in FMA" ; rdfs:label "secondary tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg"^^xsd:anyURI . obo:UBERON_0007778 obo:IAO_0000115 "An endothelium that is part of a umbilical artery." ; oboInOwl:hasDbXref "BTO:0000857" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007778" ; a owl:Class ; rdfs:label "umbilical artery endothelium" ; rdfs:subClassOf obo:UBERON_0001986, _:genid146551 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:UBERON_0007779 obo:IAO_0000115 "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces." ; obo:UBPROP_0000007 "transudative" ; obo:UBPROP_0000010 "characteristically low in protein and cellular content (unless there has been secondary concentration)" ; oboInOwl:hasDbXref "FMA:12276", "GAID:1195", "MESH:D005122", "ncithesaurus:Transudate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plasma ultrafiltrate" ; oboInOwl:id "UBERON:0007779" ; a owl:Class ; rdfs:label "transudate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001548 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0001969 ] [ a owl:Restriction ; owl:onProperty core:filtered_through ; owl:someValuesFrom obo:UBERON_0001982 ] ) ] . obo:UBERON_0007794 obo:IAO_0000115 "Any fluid produced by a serous gland." ; oboInOwl:hasBroadSynonym "serous fluid" ; oboInOwl:hasDbXref "Wikipedia:Serous_fluid" ; oboInOwl:hasExactSynonym "serosal fluid", "serous gland fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007794" ; a owl:Class ; rdfs:label "secretion of serous gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006314 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000409 ] ) ] . obo:UBERON_0007798 obo:IAO_0000115 "Anatomical system that consists of all blood and lymph vessels." ; obo:IAO_0000116 "consider merging with vasculature" ; obo:UBPROP_0000001 "The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]." ; obo:UBPROP_0000012 "in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system" ; oboInOwl:hasDbXref "BTO:0001085", "CALOHA:TS-2053", "EHDAA2:0004520", "EMAPA:35905", "MA:0002718", "NCIT:C33854", "UMLS:C0489903" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007798" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vascular system" ; rdfs:subClassOf obo:UBERON_0000467, _:genid146569 . obo:UBERON_0007806 obo:IAO_0000115 "A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord." ; obo:IAO_0000116 "TODO - this is currently defined as a bridge of mesoderm, but in EHDAA2 is extraembryonic structure split into mesoderm and blood vessels" ; oboInOwl:hasDbXref "BTO:0004705", "NCIT:C34132", "UMLS:C1516792" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007806" ; a owl:Class ; rdfs:label "connecting stalk" ; rdfs:subClassOf obo:UBERON_0000478, _:genid146576 . obo:UBERON_0007807 obo:IAO_0000115 "A vasculature that is part of a connecting stalk." ; oboInOwl:hasDbXref "EHDAA2:0000313" ; oboInOwl:hasExactSynonym "connecting stalk blood vessels" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "connecting stalk blood vessel", "vasculature of connecting stalk" ; oboInOwl:id "UBERON:0007807" ; a owl:Class ; rdfs:label "connecting stalk vasculature" ; rdfs:subClassOf _:genid146584 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007806 ] ) ] . obo:UBERON_0007808 obo:IAO_0000115 "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." ; oboInOwl:hasDbXref "CALOHA:TS-0002", "EFO:0003771" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal adipose tissue", "abdominal fat", "intra-abdominal fat" ; oboInOwl:id "UBERON:0007808" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "adipose tissue of abdominal region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0007811 obo:IAO_0000115 "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." ; oboInOwl:hasDbXref "CALOHA:TS-2356", "EV:0100009", "FMA:280881", "MA:0000006", "NCIT:C12418", "SCTID:361355005", "UMLS:C0460004", "WikipediaCategory:Head_and_neck", "galen:HeadAndNeck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cephalic area", "cephalic part of animal", "cephalic region", "head and neck", "head or neck" ; oboInOwl:id "UBERON:0007811" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "craniocervical region" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000153 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013702 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006562 ] . obo:UBERON_0007812 obo:IAO_0000115 "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton." ; obo:UBPROP_0000001 "Anatomical structure that is the terminal, flexible posterior appendage of the organism.[AAO]", "Organism subdivision which is the part of the body posterior to the vent which includes the anal and caudal fins.[TAO]" ; obo:UBPROP_0000008 "present at some time in chordate life history (eg in Urochordates, present only in free-swimming larvae). Function: propellor locomotion (in some species)" ; oboInOwl:hasDbXref "AAO:0010338", "EMAPA:16748", "MA:0000008", "NCIT:C77663", "TAO:0001117", "UMLS:C0039259", "XAO:0003026", "ZFA:0001117" ; oboInOwl:hasExactSynonym "muscular postanal tail", "postanal tail" ; oboInOwl:hasNarrowSynonym "post-anal fin tail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "post-vent region" ; oboInOwl:id "UBERON:0007812" ; oboInOwl:inSubset core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "post-anal tail" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007626 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0007144 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002415 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006071 ] ) ] . obo:UBERON_0007823 obo:IAO_0000115 "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." ; obo:IAO_0000232 "this encompasses non-skeletal tissue" ; obo:UBPROP_0000001 "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO]" ; oboInOwl:hasAlternativeId "UBERON:0007824" ; oboInOwl:hasBroadSynonym "girdle", "girdle region" ; oboInOwl:hasDbXref "EMAPA:37854", "FMA:24874", "VSAO:0000303" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fin girdle", "fin girdle region", "limb girdle", "limb girdle region" ; oboInOwl:id "UBERON:0007823" ; a owl:Class ; rdfs:label "appendage girdle region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010719 ] ) ] . obo:UBERON_0007826 obo:IAO_0000115 "Mesentery that is located in the peritoneum." ; oboInOwl:hasDbXref "FMA:20570", "TAO:0005129", "XAO:0000138", "ZFA:0005129" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007826" ; a owl:Class ; rdfs:label "peritoneal mesentery" ; rdfs:subClassOf _:genid146635, _:genid146637 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] . obo:UBERON_0007827 obo:IAO_0000115 "External part of the nose containing the external nares." ; obo:UBPROP_0000001 "Subdivision of face, the exterior of the nose, which consists of a root, dorsum, tip, columella, and right and left alae[FMA:59515]." ; oboInOwl:hasDbXref "EMAPA:37831", "FMA:59515", "NCIT:C32566", "SCTID:265785009", "UMLS:C0458561" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nose" ; oboInOwl:id "UBERON:0007827" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "external nose" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005928 ] ) ] . obo:UBERON_0007828 obo:IAO_0000115 "A bone that is part of a appendage girdle region." ; oboInOwl:hasDbXref "EMAPA:35379", "MA:0000291" ; oboInOwl:hasExactSynonym "girdle bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007828" ; a owl:Class ; rdfs:label "girdle bone/zone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010719 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007823 ] ) ] . obo:UBERON_0007829 obo:IAO_0000115 "A bone that is part of a pectoral girdle region." ; oboInOwl:hasDbXref "EMAPA:35669", "MA:0000292" ; oboInOwl:hasExactSynonym "bone of pectoral girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007829" ; oboInOwl:inSubset core:human_reference_atlas, core:vertebrate_core ; a owl:Class ; rdfs:label "pectoral girdle bone" ; rdfs:subClassOf obo:UBERON_0007828, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 _:genid145016 ) ] . obo:UBERON_0007830 obo:IAO_0000115 "A bone element or fused bone that is part of pelvic girdle." ; obo:IAO_0000116 "check sacrum, coccyx (MA does NOT include these)" ; obo:UBPROP_0000008 "typically the ilium, ischium and pubis. These can alternately be considered individual bones, or zones of a single fused bone" ; oboInOwl:hasDbXref "EMAPA:18028", "MA:0000293", "NCIT:C33287", "SCTID:426214007", "UMLS:C0030786" ; oboInOwl:hasExactSynonym "bone of pelvic girdle", "pelvic girdle bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007830" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pelvic girdle bone/zone" ; rdfs:subClassOf obo:UBERON_0005913, obo:UBERON_0007828, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ] ) ] . obo:UBERON_0007831 obo:IAO_0000115 "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." ; obo:UBPROP_0000001 "Anatomical cluster of paired dermal and endochondral bones that attaches to the dorso-posterior part of the cranium, and support the radials and pectoral fin. It consists of two components: the primary pectoral girdle consisting of the endochondral coracoid, scapula and mesocoracoid bones, and the secondary pectoral girdle consisting of the dermal posttemporal, supracleithrum, cleithrum and poscleithrum(thra) bones.[TAO]", "Girdle skeleton consisting of a set of bones linking the axial series to the forelimb/fin skeleton and offering anchoring areas for forelimb/fin and caudal musculature.[VSAO]", "Skeletal structure immediately behind the head attached to the vertebral column by muscles and supporting the forelimbs.[AAO]" ; obo:UBPROP_0000003 "The pectoral girdle is clearly of dual origin, composed of dermal as well as endochondral bones. The endochondral component, the scapulocoracoid, evolved by fusion or enlargment of several basal fin elements. (...) The dermal component of the shoulder girdle evolved from dermal bones of the body's surface. (...) Like endochondral bones, these dermal bones were passed along to tetrapods (...).[well established][VHOG]" ; obo:UBPROP_0000012 "Note that the VSAO and many ontologies use the label 'pectoral girdle' to denote the skeletal region specifically." ; oboInOwl:hasDbXref "AAO:0000422", "AAO:0000754", "EFO:0000946", "EHDAA2:0001420", "FMA:24141", "MAT:0000181", "MIAA:0000181", "NCIT:C33547", "TAO:0000407", "UMLS:C0427245", "VHOG:0001156", "VSAO:0000156", "Wikipedia:Pectoral_girdle", "XAO:0003063", "ZFA:0000407" ; oboInOwl:hasExactSynonym "skeletal parts of pectoral girdle", "skeleton of pectoral girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cingulum pectorale", "pectoral girdle", "scapular girdle" ; oboInOwl:id "UBERON:0007831" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pectoral girdle skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012475 ], _:genid146679 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg"^^xsd:anyURI . obo:UBERON_0007832 obo:IAO_0000115 "Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature." ; obo:IAO_0000116 "need to resolve whether this is a paired structure or a single belt (Paired in FMA - implicitly paired in VSAO)" ; obo:UBPROP_0000001 "Anatomical cluster by which the hind limbs are supported and attached to the vertebral column.[AAO]", "Anatomical cluster that consists of the paired basipterygia which support the pelvic fin.[TAO]", "Girdle skeleton consisting of a set of bones linking the axial series to the hindlimb/fin skeleton and offering anchoring areas for hindlimb/fin and caudal musculature.[VSAO]" ; obo:UBPROP_0000003 "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" ; obo:UBPROP_0000012 "Note that the VSAO and many ontologies use the label 'pelvic girdle' to denote the skeletal region specifically. We place the EHDAA2 class here, note that this includes the pre-cartilage condensation as parts" ; oboInOwl:hasDbXref "AAO:0000426", "AAO:0000768", "EFO:0000947", "EHDAA2:0001426", "EHDAA:7149", "EHDAA:8324", "EMAPA:18028", "FMA:87592", "MAT:0000182", "MIAA:0000182", "TAO:0000565", "VHOG:0000305", "VSAO:0000155", "Wikipedia:Pelvis", "XAO:0003064", "ZFA:0000565", "galen:PelvicGirdle", "http://people.eku.edu/ritchisong/pectoralgirdles.gif" ; oboInOwl:hasExactSynonym "pelvic girdle skeleton", "skeletal parts of pelvic girdle", "skeleton of pelvic girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic girdle" ; oboInOwl:id "UBERON:0007832" ; oboInOwl:inSubset core:efo_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "pelvic girdle skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012476 ], _:genid146701 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001271 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001271 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png"^^xsd:anyURI . obo:UBERON_0007842 obo:IAO_0000115 "Bone element that arises as a result of intramembranous ossification." ; obo:UBPROP_0000001 "Bone element that arises as a result of intramembranous ossification.[VSAO]", "Intramembranous bone that forms deep in the organism.[TAO]" ; oboInOwl:hasDbXref "AEO:0000085", "EHDAA2:0003085", "TAO:0001645", "VSAO:0000023", "XAO:0004014", "ZFA:0001636" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "membrane bones" ; oboInOwl:id "UBERON:0007842" ; a owl:Class ; rdfs:label "membrane bone" ; rdfs:subClassOf obo:UBERON_0001474, [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0001957 ] . obo:UBERON_0007844 obo:IAO_0000115 "Skeletal element that is composed of cartilage tissue and may be permanent or transient." ; obo:UBPROP_0000012 "TAO still mixes tissue and element" ; oboInOwl:hasDbXref "AAO:0011130", "CALOHA:TS-0118", "EMAPA:32730", "FMA:55107", "VSAO:0000000", "XAO:0004013", "ZFA:0001501" ; oboInOwl:hasExactSynonym "cartilage organ", "cartilaginous element", "chondrogenic element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cartilage" ; oboInOwl:id "UBERON:0007844" ; oboInOwl:inSubset core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "cartilage element" ; rdfs:subClassOf obo:UBERON_0004765, _:genid146724, _:genid146726 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004765 _:genid145076 ) ] . obo:UBERON_0007845 obo:IAO_0000115 "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." ; obo:IAO_0000116 "the connective tissue hierarchy largely follows FMA with definitions from VSAO. Note that in FMA, loose-CT is irregular-CT. This means regular-CT is necessarily equivalent to dense-regular-CT (assuming a JEPD classification)." ; oboInOwl:hasDbXref "FMA:20103" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007845" ; a owl:Class ; rdfs:label "regular connective tissue" ; rdfs:subClassOf obo:UBERON_0002384, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 ], _:genid145089 ; owl:disjointWith obo:UBERON_0011821 . obo:UBERON_0007846 obo:IAO_0000115 "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." ; obo:UBPROP_0000001 "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO]", "Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA]" ; oboInOwl:hasDbXref "FMA:64781", "NCIT:C33453", "SCTID:22560007", "UMLS:C0225333", "VSAO:0000050", "Wikipedia:Dense_regular_connective_tissue", "XAO:0004030" ; oboInOwl:hasExactSynonym "dense fibrous connective tissue", "dense regular collagenous connective tissue", "dense regular collagenous tissue", "regular dense connective tissue", "typus regularis (textus connectivus collagenosus compactus)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007846" ; a owl:Class ; rdfs:label "dense regular connective tissue" ; rdfs:subClassOf obo:UBERON_0007845, obo:UBERON_0011823 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007845 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011860 ] ) ] . obo:UBERON_0007914 obo:IAO_0000115 "A bone that is part of a craniocervical region." ; oboInOwl:hasDbXref "EMAPA:37245", "MA:0000569" ; oboInOwl:hasExactSynonym "head or neck bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial bone" ; oboInOwl:id "UBERON:0007914" ; a owl:Class ; rdfs:label "bone of craniocervical region" ; rdfs:subClassOf obo:UBERON_0001474, _:genid146760 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0007997 obo:IAO_0000115 "A sesamoid bone that is part of a manus." ; oboInOwl:hasDbXref "FMA:42353", "SCTID:368448000" ; oboInOwl:hasExactSynonym "sesamoid bone of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0007997" ; a owl:Class ; rdfs:label "sesamoid bone of manus" ; rdfs:subClassOf obo:UBERON_0001479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0008000 obo:IAO_0000115 "A sesamoid bone that is part of a pes." ; oboInOwl:hasDbXref "FMA:45096", "SCTID:244675002" ; oboInOwl:hasExactSynonym "sesamoid bone of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008000" ; a owl:Class ; rdfs:label "sesamoid bone of pes" ; rdfs:subClassOf obo:UBERON_0001479, _:genid146778 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0008001 obo:IAO_0000115 "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." ; oboInOwl:hasDbXref "FMA:7477", "NCIT:C32881", "SCTID:421560006", "UMLS:C0502414", "Wikipedia:Irregular_bone" ; oboInOwl:hasExactSynonym "os irregulare" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os irregulare" ; oboInOwl:id "UBERON:0008001" ; a owl:Class ; rdfs:label "irregular bone" ; rdfs:subClassOf obo:UBERON_0001474 . obo:UBERON_0008114 obo:IAO_0000115 "A skeletal joint that is part of a appendage girdle region." ; oboInOwl:hasDbXref "MA:0001505" ; oboInOwl:hasExactSynonym "girdle joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008114" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "joint of girdle" ; rdfs:subClassOf obo:UBERON_0000982, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0007828 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007823 ] ) ] . obo:UBERON_0008115 obo:IAO_0000115 "An anatomical surface that is part of a cartilage element." ; oboInOwl:hasDbXref "FMA:76668" ; oboInOwl:hasExactSynonym "cartilage surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008115" ; a owl:Class ; rdfs:label "surface of cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0007844 ] ) ] . obo:UBERON_0008188 obo:IAO_0000115 "A tendon that attaches_to a biceps brachii." ; oboInOwl:hasDbXref "EMAPA:25053", "FMA:38152", "SCTID:361886007" ; oboInOwl:hasExactSynonym "biceps brachii tendon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tendon of biceps brachii muscle" ; oboInOwl:id "UBERON:0008188" ; a owl:Class ; rdfs:label "tendon of biceps brachii" ; rdfs:subClassOf obo:UBERON_0000043 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001507 ] ) ] . obo:UBERON_0008192 obo:IAO_0000115 "A tendon that attaches_to a triceps brachii." ; oboInOwl:hasDbXref "FMA:38380", "SCTID:245105007" ; oboInOwl:hasExactSynonym "triceps brachii tendon", "triceps tendon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tendon of triceps brachii muscle" ; oboInOwl:id "UBERON:0008192" ; a owl:Class ; rdfs:label "tendon of triceps brachii" ; rdfs:subClassOf obo:UBERON_0000043 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000043 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001509 ] ) ] . obo:UBERON_0008193 obo:IAO_0000115 "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." ; obo:IAO_0000116 "subclasses of this should be checked for taxonomic consistency" ; obo:UBPROP_0000008 "Skeletal pneumaticity is the presence of air spaces within bones. Skeletal pneumaticity exists only in synapsids and archosaurs. It is generally produced during development by excavation of bone by pneumatic diverticula (air sacs) from an air-filled space such as the lungs or nasal cavity. Pneumatization is highly variable between individuals, and bones not normally pneumatized can become pneumatized in pathological development. Pneumatization occurs in the skulls of mammals, crocodilians and birds among extant groups, as well as extinct archosaurs including the dinosaurs and pterosaurs. Pneumatic spaces include the paranasal sinuses and some of the mastoid cells[WP]. [Wikipedia:Skeletal_pneumaticity]" ; oboInOwl:hasDbXref "FMA:7478", "SCTID:333008005", "Wikipedia:Skeletal_pneumaticity", "galen:PneumaticBone" ; oboInOwl:hasExactSynonym "os pneumaticum", "pneumatic bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hollow bone" ; oboInOwl:id "UBERON:0008193" ; a owl:Class ; rdfs:label "pneumatized bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010528 ] ) ] . obo:UBERON_0008196 obo:IAO_0000115 "Any muscle organ that is part of a pectoral girdle region." ; obo:UBPROP_0000012 "EMAPA has both non-skeletal and skeletal types, with the non-skeletal also including a chest muscle, so we place the skeletal class here as the most accurate" ; oboInOwl:hasDbXref "EMAPA:17748", "FMA:37347" ; oboInOwl:hasExactSynonym "muscle of shoulder girdle", "pectoral girdle muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008196" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "muscle of pectoral girdle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004471 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_0008198 obo:IAO_0000115 "The nail plate is the hard and translucent portion of the nail, composed of keratin." ; obo:UBPROP_0000012 "in FMA, the nail is the nail plate" ; oboInOwl:hasDbXref "EMAPA:35583", "MA:0002708", "NCIT:C34216", "SCTID:372177002", "Wikipedia:Nail_plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lamina unguis" ; oboInOwl:id "UBERON:0008198" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "nail plate" ; rdfs:subClassOf obo:UBERON_0013754, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000312 ], _:genid146833 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9f/Fingernail_label.jpg"^^xsd:anyURI . obo:UBERON_0008199 obo:IAO_0000115 "A subdivision of the face that is the anteriormost part of the lower jaw region." ; obo:UBPROP_0000001 "Surface structure that is the anteriormost region of the lower jaw.[TAO]" ; obo:UBPROP_0000007 "mental" ; obo:UBPROP_0000008 "In humans, the chin is the lowermost part of the face. It is formed by the lower front of the mandible. The chin developed as a point of muscular attachment facilitating minute movements of the lips associated with speech. In human evolution, the chin is a cladistic apomorphy, partially defining anatomically modern Humans as distinct from archaic forms" ; oboInOwl:hasDbXref "EMAPA:37827", "FMA:46495", "GAID:67", "MESH:D002680", "NCIT:C81169", "SCTID:362632004", "TAO:0002254", "Wikipedia:Chin", "galen:Chin" ; oboInOwl:hasExactSynonym "mental part of face", "mental region", "mental region of face", "regio mentalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mentum" ; oboInOwl:id "UBERON:0008199" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chin" ; rdfs:subClassOf obo:UBERON_0001444, _:genid146839, _:genid146841 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/60/Gray1195.png"^^xsd:anyURI . obo:UBERON_0008200 obo:IAO_0000115 "The part of the face above the eyes[MESH]. In human anatomy, the forehead is the fore part of the head. It is, formally, an area of the head bounded by three features, two of the skull and one of the scalp. The top of the forehead is marked by the hairline, the edge of the area where hair on the scalp grows. The bottom of the forehead is marked by the supraorbital ridge, the bone feature of the skull above the eyes. The two sides of the forehead are marked by the temporal ridge, a bone feature that links the supraorbital ridge to the coronal suture line and beyond[WP]." ; oboInOwl:hasDbXref "EMAPA:37869", "FMA:63864", "GAID:74", "MESH:D005546", "NCIT:C89803", "SCTID:362614004", "UMLS:C0016540", "Wikipedia:Forehead", "galen:Forehead" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fore head", "sinciput" ; oboInOwl:id "UBERON:0008200" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "forehead" ; rdfs:subClassOf obo:UBERON_0001444, _:genid146851 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/83/Forhead_01_ies.jpg"^^xsd:anyURI . obo:UBERON_0008202 obo:IAO_0000116 "todo - consider obsoletion" ; obo:UBPROP_0000012 "in MA, this includes the femur. i.e. pelvic girdle bone or femur; note that this makes the ilium etc in MA hindlimb bones. in MA this is a hindlimb bone" ; oboInOwl:hasDbXref "EMAPA:37308", "FMA:42854", "MA:0000655", "SCTID:304907005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008202" ; oboInOwl:inSubset core:grouping_class, core:non_informative, core:pheno_slim ; a owl:Class ; rdfs:label "bone of hip region" ; rdfs:subClassOf obo:UBERON_0001474, _:genid146858 . obo:UBERON_0008203 obo:IAO_0000115 "The part of the ventral body cavity that is within the pelvis." ; oboInOwl:hasDbXref "EMAPA:37235", "FMA:9738", "MA:0003089", "SCTID:281903009", "Wikipedia:Pelvic_cavity" ; oboInOwl:hasExactSynonym "space of pelvic compartment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavitas pelvis" ; oboInOwl:id "UBERON:0008203" ; a owl:Class ; rdfs:label "pelvic cavity" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035819 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg"^^xsd:anyURI . obo:UBERON_0008229 obo:IAO_0000115 "Musculature system of the pharyngeal and head regions." ; obo:UBPROP_0000012 "in MA this is restricted to skeletal muscles" ; oboInOwl:hasDbXref "EMAPA:37259", "MA:0000571", "TAO:0000328", "ZFA:0000328" ; oboInOwl:hasExactSynonym "head or neck muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "head muscles", "head or neck muscle" ; oboInOwl:id "UBERON:0008229" ; a owl:Class ; rdfs:label "craniocervical region musculature" ; rdfs:subClassOf obo:UBERON_0001015, _:genid146878 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0008230 obo:IAO_0000115 "Either of two muscles of the calf of the leg." ; oboInOwl:hasDbXref "BTO:0000864", "EMAPA:35867", "MA:0002425", "NCIT:C53076", "UMLS:C1710422" ; oboInOwl:hasExactSynonym "tibialis muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008230" ; a owl:Class ; rdfs:label "tibialis" ; rdfs:subClassOf obo:UBERON_0000366, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] . obo:UBERON_0008231 obo:IAO_0000115 "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax." ; oboInOwl:hasDbXref "EMAPA:37234", "FMA:24217", "MA:0000028", "SCTID:362666008" ; oboInOwl:hasExactSynonym "dorsum of thorax", "posterior part of thorax", "thoracic back", "thoracic part of back", "upper back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "back of thorax" ; oboInOwl:id "UBERON:0008231" ; a owl:Class ; rdfs:label "dorsal thoracic segment of trunk" ; rdfs:subClassOf obo:UBERON_0000475, _:genid146891, _:genid146893 . obo:UBERON_0008242 obo:IAO_0000115 "A muscle of back that is part of a lower back." ; oboInOwl:hasDbXref "EMAPA:37262", "MA:0000502", "SCTID:317178000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008242" ; a owl:Class ; rdfs:label "lower back muscle" ; rdfs:subClassOf obo:UBERON_0003833, _:genid146908 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002324 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 ] ) ] . obo:UBERON_0008243 obo:IAO_0000115 "A muscle of back that is part of a dorsal thoracic segment of trunk." ; oboInOwl:hasDbXref "EMAPA:37261", "MA:0000508", "SCTID:305071003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008243" ; a owl:Class ; rdfs:label "upper back muscle" ; rdfs:subClassOf obo:UBERON_0003830, _:genid146917 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002324 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008231 ] ) ] . obo:UBERON_0008255 obo:IAO_0000115 "A clavicle that is in the right side of a entire appendicular skeleton." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:13322" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008255" ; a owl:Class ; rdfs:label "right clavicle" ; rdfs:subClassOf obo:UBERON_0001105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001105 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0002091 ] ) ] . obo:UBERON_0008256 obo:IAO_0000115 "A clavicle that is in the left side of a entire appendicular skeleton." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:13323" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008256" ; a owl:Class ; rdfs:label "left clavicle" ; rdfs:subClassOf obo:UBERON_0001105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001105 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0002091 ] ) ] . obo:UBERON_0008266 obo:IAO_0000115 "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]." ; obo:UBPROP_0000001 "The collagen fibers, running from the cementum to the alveolar bone, that suspend a tooth in its socket; they include apical, oblique, horizontal, and alveolar crest fibers, indicating that the orientation of the fibers varies at different levels[http://www.drugs.com/dict/desmodentium.html].", "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. It consist of cells, extracellular compartment of fibers. The cells are fibroblast, epithelial, undifferentiated mesenchymal cells, bone and cementum cells. The extracellular compartment consists of collagen fibers bundles embedded in ground substance. The PDL substance has been estimated to be 70% water and is thought to have a significant effect on the tooth's ability to withstand stress loads[WP][BTO:0001020, Wikipedia:Periodontal_fiber, https://github.com/obophenotype/uberon/issues/21]." ; obo:UBPROP_0000012 "FMA treats periodontium and periodontal ligament as the same; it has a separate class desmodentium, which we place here even though it is classified as fetal in FMA" ; oboInOwl:hasDbXref "BTO:0001020", "CALOHA:TS-0763", "EMAPA:35679", "FMA:56665", "GAID:1259", "MA:0002467", "MESH:D010513", "SCTID:245775004", "Wikipedia:Periodontal_fiber" ; oboInOwl:hasExactSynonym "fibra periodontalis", "periodontal fiber", "periodontal fibre" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PDL", "alveolar periosteum", "alveolodental ligament", "alveolodental membrane", "desmodontium", "odontoperiosteum", "paradentium", "peridental membrane", "peridontal fiber", "peridontal fibre", "peridontal ligament", "peridontal ligament fiber", "peridontal ligament fibre", "peridontal membrane", "peridontium", "periodontium" ; oboInOwl:id "UBERON:0008266" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "periodontal ligament" ; rdfs:seeAlso obo:FMA_76870 ; rdfs:subClassOf obo:UBERON_0008846, _:genid146938, _:genid146940, _:genid146942 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001758 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg"^^xsd:anyURI . obo:UBERON_0008281 obo:IAO_0000115 "A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them." ; oboInOwl:hasDbXref "BTO:0001838", "FMA:306006", "MESH:D014083", "NCIT:C34313", "SCTID:53301001", "UMLS:C0040442" ; oboInOwl:hasExactSynonym "dental bud", "dental germ", "tooth germ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008281" ; a owl:Class ; rdfs:label "tooth bud" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005087 ] . obo:UBERON_0008307 obo:IAO_0000115 "An endothelium that is part of a heart [Automatically generated definition]." ; obo:IAO_0000232 "this class includes any endothelia that are part of the heart. This might include the endocardial epithelia, as well as endothelia of vessels that are considered strictly part of the heart (e.g. outflow tract). As a grouping class, this may lack utility, and pending review this class may be obsoleted. For annotation consider a more specific class." ; oboInOwl:hasDbXref "BTO:0004293" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac endothelium" ; oboInOwl:id "UBERON:0008307" ; a owl:Class ; rdfs:label "heart endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0008310 obo:IAO_0000115 "A gland that is part of a nasopharynx." ; oboInOwl:hasDbXref "FMA:55076", "SCTID:178973008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008310" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "nasopharyngeal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0008320 obo:IAO_0000115 "The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery." ; obo:IAO_0000116 "TODO - split generic structure from arterial tree" ; oboInOwl:hasDbXref "BTO:0005085", "FMA:66318", "SCTID:282044005", "Wikipedia:Penile_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "artery of penis", "penile artery" ; oboInOwl:id "UBERON:0008320" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "common penile artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0007315 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000989 ], _:genid146984 . obo:UBERON_0008321 obo:IAO_0000115 "The deep artery of the penis (artery to the corpus cavernosum), one of the terminal branches of the internal pudendal, arises from that vessel while it is situated between the two fascia of the urogenital diaphragm (deep perineal pouch). It pierces the inferior fascia, and, entering the crus penis obliquely, runs forward in the center of the corpus cavernosum penis, to which its branches are distributed." ; oboInOwl:hasDbXref "BTO:0005086", "FMA:19794", "SCTID:244293007", "Wikipedia:Deep_artery_of_the_penis" ; oboInOwl:hasExactSynonym "arteria profunda penis", "deep penile artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria cavernosa penis", "arteria profunda penis", "cavernosal artery" ; oboInOwl:id "UBERON:0008321" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "deep artery of penis" ; rdfs:subClassOf _:genid146997, _:genid146999, _:genid147001 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004713 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray543.png"^^xsd:anyURI . obo:UBERON_0008322 obo:IAO_0000115 "The deep artery of clitoris is a branch of the internal pudendal artery." ; oboInOwl:hasDbXref "FMA:20870", "SCTID:244297008", "Wikipedia:Deep_artery_of_clitoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteria profunda clitoridis" ; oboInOwl:id "UBERON:0008322" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "deep artery of clitoris" ; rdfs:subClassOf _:genid147015, _:genid147017 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0006608 ] ) ] . obo:UBERON_0008324 obo:IAO_0000115 "With numerous vascular spaces that may become engorged with blood." ; oboInOwl:hasDbXref "Wikipedia:Erectile_tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008324" ; a owl:Class ; rdfs:comment "Examples: corpus cavernosum or penis or clitoris" ; rdfs:label "erectile tissue" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0008331 obo:IAO_0000115 "A smooth muscle tissue that is part of a clitoris." ; oboInOwl:hasDbXref "BTO:0005000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "clitoris smooth muscle" ; oboInOwl:id "UBERON:0008331" ; a owl:Class ; rdfs:label "clitoral smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] . obo:UBERON_0008338 obo:IAO_0000115 "The sole is the bottom of the foot." ; obo:UBPROP_0000008 "In humans is the sole of the foot anatomically referred to as the plantar aspect. The equivalent surface in ungulates is the hoof" ; oboInOwl:hasDbXref "BTO:0005078", "CALOHA:TS-0379", "FMA:25000", "NCIT:C33326", "SCTID:57999000", "UMLS:C0230463", "Wikipedia:Sole_(foot)", "galen:SoleOfFoot" ; oboInOwl:hasExactSynonym "planta", "plantar part of foot", "plantar region", "regio plantaris", "sole", "sole of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelma", "planta", "sole of foot", "sole of the foot", "soles of the feet" ; oboInOwl:id "UBERON:0008338" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "plantar part of pes" ; rdfs:subClassOf obo:UBERON_0005445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008837 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/41/Soles2.jpg"^^xsd:anyURI . obo:UBERON_0008339 oboInOwl:hasDbXref "BTO:0003122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008339" ; a owl:Class ; rdfs:label "microvascular endothelium" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/2186" ; rdfs:subClassOf obo:UBERON_0004852 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 _:genid145380 ) ] . obo:UBERON_0008340 obo:IAO_0000115 "A saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canth[WP]." ; oboInOwl:hasDbXref "MA:0002874", "Wikipedia:Nasal_bridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008340" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasal bridge" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], _:genid147054 . obo:UBERON_0008341 obo:IAO_0000115 "The tissue that links the nasal tip to the nasal base, and separates the nares. It is the inferior margin of the nasal septum[EoM]." ; oboInOwl:hasDbXref "EMAPA:37832", "FMA:59725", "SCTID:361930008" ; oboInOwl:hasExactSynonym "columella of nose", "nasal columella" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columella" ; oboInOwl:id "UBERON:0008341" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "columella nasi" ; rdfs:subClassOf obo:UBERON_0003102, _:genid147057 . obo:UBERON_0008342 obo:IAO_0000115 "An intestinal villus in the duodenum." ; oboInOwl:hasDbXref "FMA:63300" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008342" ; a owl:Class ; rdfs:label "intestinal villus of duodenum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000320 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001213 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0008343 obo:IAO_0000115 "An intestinal villus in the jejunum." ; oboInOwl:hasDbXref "FMA:63301" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008343" ; a owl:Class ; rdfs:label "intestinal villus of jejunum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000399 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001213 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0008344 obo:IAO_0000115 "An intestinal villus in the ileum." ; oboInOwl:hasDbXref "FMA:63302" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008344" ; a owl:Class ; rdfs:label "intestinal villus of ileum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000331 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001213 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0008345 obo:IAO_0000115 "An epithelium that is part of a ileum." ; oboInOwl:hasDbXref "EMAPA:35423", "FMA:17233", "MA:0003217", "SCTID:47046000" ; oboInOwl:hasExactSynonym "epithelium of ileum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008345" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ileal epithelium" ; rdfs:subClassOf _:genid147084 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0008346 obo:IAO_0000115 "An epithelium that is part of a duodenum." ; oboInOwl:hasDbXref "CALOHA:TS-2087", "EMAPA:19078", "FMA:17231", "MA:0003208", "SCTID:66036002" ; oboInOwl:hasExactSynonym "epithelium of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008346" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodenal epithelium" ; rdfs:subClassOf _:genid147092 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0008367 obo:IAO_0000115 "An epithelium that is part of a breast." ; oboInOwl:hasDbXref "BTO:0001428" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008367" ; a owl:Class ; rdfs:label "breast epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:UBERON_0008397 obo:IAO_0000115 "Epithelium pertaining to the trachea and bronchi." ; oboInOwl:hasDbXref "BTO:0002925", "CALOHA:TS-1063" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bronchotracheal epithelium" ; oboInOwl:id "UBERON:0008397" ; a owl:Class ; rdfs:label "tracheobronchial epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007196 ] ) ] . obo:UBERON_0008420 obo:IAO_0000115 "An epithelium that is part of a buccal mucosa." ; oboInOwl:hasDbXref "BTO:0004803" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008420" ; a owl:Class ; rdfs:label "buccal epithelium" ; rdfs:subClassOf _:genid147111 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006956 ] ) ] . obo:UBERON_0008425 obo:IAO_0000115 "A ridge of epidermal cells that will form the mammary placodes." ; obo:IAO_0000116 "consider splitting ridge (precursor) and milk line" ; obo:UBPROP_0000008 "These buds are either located in the thoracic region in primates, in the inguinal area in ungulates or along the entire length of the trunk in rodents and pigs. In humans, milk lines appear in the seventh week of embryonic development" ; obo:UBPROP_0000011 "The first manifestation of the mammary gland in many mammals is an elevated ridge or milk line, which then fragments into individual buds in specific regions lateral of the dorsal midline. After initial development of the milk lines they go into remission.", "in mouse, mammary gland development begins shortly after mid-gestation (about E10.5); epidermal cells within the milk line become columnar and multilayered, defining a ridge that protrudes above and below the plane of the single-layered primitive epidermis or periderm; by E11.5, five pairs of lens-shaped placodes form along the mammary line at the site of each future nipple.[MP]" ; oboInOwl:hasDbXref "EMAPA:18541", "Wikipedia:Milk_line" ; oboInOwl:hasExactSynonym "mammary fold", "mammary gland ridge" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary line", "milk line" ; oboInOwl:id "UBERON:0008425" ; a owl:Class ; rdfs:label "mammary ridge" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001911 ] . obo:UBERON_0008429 obo:IAO_0000115 "A vertebral foramen that is part of a cervical vertebra." ; oboInOwl:hasDbXref "FMA:13480", "SCTID:280833008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008429" ; a owl:Class ; rdfs:label "cervical vertebral foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0008430 obo:IAO_0000115 "A vertebral foramen that is part of a lumbar vertebra." ; oboInOwl:hasDbXref "FMA:24826", "SCTID:280835001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008430" ; a owl:Class ; rdfs:label "lumbar vertebral foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid145456 ] . obo:UBERON_0008431 obo:IAO_0000115 "A vertebral foramen that is part of a sacral vertebra." ; oboInOwl:hasDbXref "FMA:31749" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008431" ; a owl:Class ; rdfs:label "sacral foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001094 ] ) ] . obo:UBERON_0008432 obo:IAO_0000115 "A vertebral foramen that is part of a thoracic vertebra." ; oboInOwl:hasDbXref "FMA:9143", "SCTID:280834002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008432" ; a owl:Class ; rdfs:label "thoracic vertebral foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002347 ] ) ] . obo:UBERON_0008433 obo:IAO_0000115 "A neural arch that is part of a lumbar vertebra." ; oboInOwl:hasDbXref "FMA:16076", "SCTID:312766000" ; oboInOwl:hasExactSynonym "arch of lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008433" ; a owl:Class ; rdfs:label "lumbar vertebral arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] . obo:UBERON_0008434 obo:IAO_0000115 "A neural arch that is part of a cervical vertebra." ; oboInOwl:hasDbXref "FMA:23893", "SCTID:165269004" ; oboInOwl:hasExactSynonym "arch of cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008434" ; a owl:Class ; rdfs:label "cervical vertebral arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0008435 obo:IAO_0000115 "A neural arch that is part of a sacral vertebra." ; oboInOwl:hasDbXref "FMA:32401" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008435" ; a owl:Class ; rdfs:label "vertebral arch of sacral segment" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001094 ] ) ] . obo:UBERON_0008436 obo:IAO_0000115 "A neural arch that is part of a thoracic vertebra." ; oboInOwl:hasDbXref "FMA:9151", "SCTID:312764002" ; oboInOwl:hasExactSynonym "arch of thoracic vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008436" ; a owl:Class ; rdfs:label "thoracic vertebral arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003861 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002347 ] ) ] . obo:UBERON_0008447 obo:IAO_0000115 "Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation." ; oboInOwl:hasDbXref "EMAPA:37762", "FMA:44281", "GAID:259", "MA:0003112", "MESH:D013640", "NCIT:C33735", "SCTID:182221001", "SCTID:361283005", "UMLS:C1527245", "Wikipedia:Intertarsal_articulations" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulationes intertarsale", "articulationes intertarsales", "articulationes intertarseae", "intermetatarsal joint", "intertarsal", "intertarsal articulation", "intertarsal joint", "tarsal joint", "tarsal joints" ; oboInOwl:id "UBERON:0008447" ; a owl:Class ; rdfs:label "intertarsal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ], _:genid147172 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid145494 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray360.png"^^xsd:anyURI . obo:UBERON_0008456 obo:IAO_0000115 "A prezygapophysis that is part of a lumbar vertebra." ; oboInOwl:hasDbXref "FMA:16126", "SCTID:305677003" ; oboInOwl:hasExactSynonym "cranial articular process of lumbar vertebra", "superior articular process of lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008456" ; a owl:Class ; rdfs:label "prezygapophysis of lumbar vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] . obo:UBERON_0008457 obo:IAO_0000115 "A prezygapophysis that is part of a sacral vertebra." ; oboInOwl:hasDbXref "FMA:16215" ; oboInOwl:hasExactSynonym "articular process of sacral segment", "processus articularis superior (os sacrum)", "processus articularis superior ossis sacri", "superior articular process of sacral segment", "superior articular process of sacral vertebra", "superior articular process of sacrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008457" ; a owl:Class ; rdfs:label "prezygapophysis of sacral vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001094 ] ) ] . obo:UBERON_0008459 obo:IAO_0000115 "A prezygapophysis that is part of a cervical vertebra." ; oboInOwl:hasDbXref "FMA:23969", "SCTID:57767002" ; oboInOwl:hasExactSynonym "superior articular process of cervical segment", "superior articular process of cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008459" ; a owl:Class ; rdfs:label "prezygapophysis of cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0008460 obo:IAO_0000115 "A prezygapophysis that is part of a thoracic vertebra." ; oboInOwl:hasDbXref "FMA:9155", "SCTID:367801006" ; oboInOwl:hasExactSynonym "cranial articular process of thoracic vertebra", "processus articularis (zygapophysis) thoracicus superior", "superior apophyseal process", "superior articular process of thoracic vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "superior zygapophysis" ; oboInOwl:id "UBERON:0008460" ; a owl:Class ; rdfs:label "prezygapophysis of thoracic vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001079 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002347 ] ) ] . obo:UBERON_0008461 obo:IAO_0000115 "An postzygapophysis that is part of a lumbar vertebra." ; oboInOwl:hasDbXref "FMA:16127", "SCTID:306283004" ; oboInOwl:hasExactSynonym "caudal articular process of lumbar vertebra", "inferior articular process of lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008461" ; a owl:Class ; rdfs:label "postzygapophysis of lumbar vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] . obo:UBERON_0008462 obo:IAO_0000115 "An postzygapophysis that is part of a cervical vertebra." ; oboInOwl:hasDbXref "FMA:23970", "SCTID:61633005" ; oboInOwl:hasExactSynonym "inferior articular process of cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008462" ; a owl:Class ; rdfs:label "postzygapophysis of cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0008463 obo:IAO_0000115 "An postzygapophysis that is part of a thoracic vertebra." ; oboInOwl:hasDbXref "FMA:9156", "SCTID:367814007" ; oboInOwl:hasExactSynonym "caudal articular process of thoracic vertebra", "inferior apophyseal process", "inferior articular process of thoracic vertebra", "inferior zygapophysis", "processus articularis (zygapophysis) thoracicus inferior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008463" ; a owl:Class ; rdfs:label "postzygapophysis of thoracic vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001080 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002347 ] ) ] . obo:UBERON_0008522 obo:IAO_0000115 "Any muscle organ that is part of an nose." ; oboInOwl:hasDbXref "FMA:73758", "NCIT:C33158", "SCTID:244730009", "UMLS:C0224219" ; oboInOwl:hasExactSynonym "muscle of nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008522" ; a owl:Class ; rdfs:label "nasal muscle" ; rdfs:subClassOf obo:UBERON_0001577 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] . obo:UBERON_0008523 obo:IAO_0000115 "The infrahyoid muscles are a group of four pairs of muscles in the anterior part of the neck. (The term infrahyoid refers to the region below to the hyoid bone in the neck. ) Collectively, they are referred to as the strap muscles, because the muscles are long and flat much like a strap." ; oboInOwl:hasDbXref "FMA:13338", "SCTID:244829008", "Wikipedia:Infrahyoid_muscles" ; oboInOwl:hasExactSynonym "musculus infrahyoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "infrahyoid", "infrahyoid muscle", "infrahyoidala", "musculi infrahyoidei", "strap muscle", "strap muscles" ; oboInOwl:id "UBERON:0008523" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "infrahyoid muscle" ; rdfs:subClassOf _:genid147255 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005493 _:genid145579 ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/48/Infrahyoid_muscles.png"^^xsd:anyURI . obo:UBERON_0008529 obo:IAO_0000115 "The piriformis is a muscle in the gluteal region that originates from the anterior (front) part of the sacrum, the part of the spine in the gluteal region, and from the superior margin of the greater sciatic notch (as well as the sacroiliac joint capsule and the sacrotuberous ligament). It exits the pelvis through the greater sciatic foramen to insert on the greater trochanter of the femur. Its tendon often joins with the tendons of the superior gemellus, inferior gemellus, and obturator internus muscles prior to insertion[WP,modified]." ; oboInOwl:hasDbXref "EMAPA:36239", "FMA:19082", "SCTID:245019009", "Wikipedia:Piriformis_muscle" ; oboInOwl:hasExactSynonym "m.piriformis", "piriformis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus piriformis", "piriform muscle", "piriformis muscle" ; oboInOwl:id "UBERON:0008529" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "piriformis muscle" ; rdfs:subClassOf obo:UBERON_0002000, _:genid147266, _:genid147268, _:genid147270 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Posterior_Hip_Muscles_1.PNG"^^xsd:anyURI . obo:UBERON_0008571 obo:IAO_0000115 "A muscle in the region above the hyoid bone in the neck. The suprahyoid muscles include digastric, stylohyoid, geniohyoid, and mylohyoid." ; oboInOwl:hasDbXref "FMA:46290", "SCTID:244824003", "Wikipedia:Suprahyoid_muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculi suprahyoidei", "suprahyoid", "suprahyoidala" ; oboInOwl:id "UBERON:0008571" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "suprahyoid muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/697"^^xsd:anyURI ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005493 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000096 ; owl:someValuesFrom obo:UBERON_0001685 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/58/Suprahyoid_muscles.png"^^xsd:anyURI . obo:UBERON_0008572 obo:IAO_0000115 "The posterior cricoarytenoid muscles are extremely small, paired muscles that extend from the posterior cricoid cartilage to the arytenoid cartilages in the larynx. By rotating the arytenoid cartilages laterally, these muscles abduct the vocal cords and thereby open the rima glottidis. Their action opposes the lateral cricoarytenoid muscles. The posterior cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X). Paralysis of the posterior cricoarytenoid muscles may lead to asphyxiation as they are the only laryngeal muscles to open the true vocal folds, allowing inspiration and expiration." ; oboInOwl:hasDbXref "FMA:46576", "SCTID:244812005", "Wikipedia:Posterior_cricoarytenoid_muscle" ; oboInOwl:hasExactSynonym "posterior cricoarytenoid", "posterior cricoarytenoid muscle", "posterior cricoarytenoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cricoarytaenoideus posterior", "cricoarytænoideus posterior", "musculus cricoarytenoideus posterior" ; oboInOwl:id "UBERON:0008572" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "posterior crico-arytenoid" ; rdfs:subClassOf obo:UBERON_0010932, _:genid147286, _:genid147288, _:genid147290, _:genid147292 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9d/Musculuscricoarytenoideusposterior.png"^^xsd:anyURI . obo:UBERON_0008573 obo:IAO_0000115 "The lateral cricoarytenoid (also anterior cricoarytenoid) muscles extend from the lateral cricoid cartilage to the ipsilateral arytenoid cartilage. By rotating the arytenoid cartilages medially, these muscles adduct the vocal cords and thereby close the rima glottidis, protecting the airway. (Their action is antagonistic to that of the posterior cricoarytenoid muscles. ) The lateral cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X)." ; oboInOwl:hasDbXref "FMA:46579", "SCTID:244813000", "Wikipedia:Lateral_cricoarytenoid_muscle" ; oboInOwl:hasExactSynonym "lateral cricoarytenoid", "lateral cricoarytenoid muscle", "lateral cricoarytenoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cricoarytaenoideus lateralis", "cricoarytaenoideus lateralis muscle", "cricoarytænoideus lateralis", "cricoarytænoideus lateralis muscle", "musculus cricoarytenoideus lateralis" ; oboInOwl:id "UBERON:0008573" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lateral crico-arytenoid" ; rdfs:subClassOf obo:UBERON_0010932, _:genid147301, _:genid147303, _:genid147305, _:genid147307 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/34/Musculuscricoarytenoideuslateralis.png"^^xsd:anyURI . obo:UBERON_0008585 obo:IAO_0000115 "The levator veli palatini is the elevator muscle of the velum palatinum in the human body. During swallowing, it contracts, elevating the soft palate to help prevent food from entering the nasopharynx. It is innervated via the pharyngeal plexus, primarily by the vagus nerve (CN X). The levator veli palatini (Levator palati) is a thick, rounded muscle situated lateral to the choanC&. It arises from the under surface of the apex of the petrous part of the temporal bone and from the medial lamina of the cartilage of the auditory tube. After passing above the upper concave margin of the Constrictor pharyngis superior it spreads out in the palatine velum, its fibers extending obliquely downward and medially to the middle line, where they blend with those of the opposite side." ; obo:UBPROP_0000001 "The levator veli palatini is part of the soft palate that attaches to the cranial base, pharyngotympanic tube and the soft palate and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" ; oboInOwl:hasDbXref "FMA:46727", "SCTID:244795001", "Wikipedia:Levator_veli_palatini" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "levator palati", "levator veli", "levator veli palatini muscle", "levator velum palatini muscle", "musculus levator veli palatini" ; oboInOwl:id "UBERON:0008585" ; a owl:Class ; rdfs:label "levator veli palatini" ; rdfs:subClassOf obo:UBERON_0003682, _:genid147319, _:genid147321, _:genid147323 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Musculuslevatorvelipalatini.png"^^xsd:anyURI . obo:UBERON_0008588 obo:IAO_0000115 "The Procerus is a small pyramidal slip of muscle deep to the superior orbital nerve, artery and vein." ; oboInOwl:hasDbXref "FMA:46769", "SCTID:244731008", "Wikipedia:Procerus_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "depressor glabellae", "musculus procerus glabellae", "procerus muscle", "pyramidalis nasi" ; oboInOwl:id "UBERON:0008588" ; a owl:Class ; rdfs:label "procerus" ; rdfs:subClassOf obo:UBERON_0008522, _:genid147333 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Procerus.png"^^xsd:anyURI . obo:UBERON_0008593 obo:IAO_0000115 "Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." ; oboInOwl:hasDbXref "FMA:46810", "MFMO:0000138", "NCIT:C53183", "SCTID:244739005", "SCTID:244740007", "UMLS:C0224115", "Wikipedia:Zygomaticus_major_muscle" ; oboInOwl:hasExactSynonym "zygomatic muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auriculolabialis superior", "musculus zygomaticus major", "zygomatic major", "zygomatic major muscle", "zygomaticcus major", "zygomaticus major" ; oboInOwl:id "UBERON:0008593" ; oboInOwl:inSubset core:feed_aligned, core:human_reference_atlas ; a owl:Class ; rdfs:label "zygomaticus major muscle" ; rdfs:subClassOf obo:UBERON_0010437, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011386 ], _:genid147353, _:genid147355 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0005467 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000102 ; owl:someValuesFrom obo:UBERON_0008594 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001683 ] _:genid145658 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0018149 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Zygomaticus.png"^^xsd:anyURI . obo:UBERON_0008594 obo:IAO_0000115 "Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. This muscle is ventral to the zygomaticus minor and dorsal to the platysma muscle. In many mammals this muscle also has an attachment to the cartilage of the external ear, in which case it is called the auriculolabialis inferior. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." ; oboInOwl:hasDbXref "FMA:46811", "MFMO:0000137", "NCIT:C53184", "SCTID:244741006", "UMLS:C0224116", "Wikipedia:Zygomaticus_minor_muscle" ; oboInOwl:hasExactSynonym "musculus quadratus labii superioris, zygomatic head", "musculus zygomaticus minor", "square muscle of the upper lip, zygomatic head" ; oboInOwl:hasNarrowSynonym "auriculolabialis superior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "auriculolabialis superior" ; oboInOwl:id "UBERON:0008594" ; oboInOwl:inSubset core:feed_aligned, core:human_reference_atlas ; a owl:Class ; rdfs:label "zygomaticus minor muscle" ; rdfs:subClassOf obo:UBERON_0010437, _:genid147379 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0008593 ] _:genid145681 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011386 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0018265 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Musculuszygomaticusminor.png"^^xsd:anyURI . obo:UBERON_0008595 obo:IAO_0000115 "The levator anguli oris (caninus) is a facial muscle of the mouth arising from the canine fossa, immediately below the infraorbital foramen. Its fibers are inserted into the angle of the mouth, intermingling with those of the Zygomaticus, Triangularis, and Orbicularis oris." ; oboInOwl:hasDbXref "FMA:46822", "SCTID:141501002", "Wikipedia:Levator_anguli_oris_muscle" ; oboInOwl:hasExactSynonym "levator anguli oris muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "caninus", "caninus muscle", "levator anguli oris", "musculus levator anguli oris" ; oboInOwl:id "UBERON:0008595" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "levator anguli oris" ; rdfs:subClassOf obo:UBERON_0001577, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011386 ], _:genid147388, _:genid147390 . obo:UBERON_0008596 obo:IAO_0000115 "A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip and inferior to the lower lip (in humans this region is called the chin or mental region), the orbicularis oris muscle, and the mandible in the symphyseal region. See Diogo et al., 2009; Burrows et al., 2011)." ; obo:RO_0002171 obo:UBERON_0001581 ; oboInOwl:hasDbXref "FMA:46825", "MFMO:0000122", "SCTID:244744003", "Wikipedia:Mentalis" ; oboInOwl:hasExactSynonym "mentalis", "musculus mentalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008596" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "mentalis muscle" ; rdfs:subClassOf obo:UBERON_0001577, _:genid147408, _:genid147410, _:genid147412, _:genid147414 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001835 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0010933 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0018542 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/37/Mentalis.png"^^xsd:anyURI . obo:UBERON_0008597 obo:IAO_0000115 "The Depressor anguli oris (Triangularis) arises from the oblique line of the mandible, whence its fibers converge, to be inserted, by a narrow fasciculus, into the angle of the mouth." ; oboInOwl:hasDbXref "EMAPA:37842", "FMA:46828", "SCTID:361812000", "Wikipedia:Depressor_anguli_oris_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "depressor anguli oris", "musculus depressor anguli oris", "triangularis", "triangularis muscle" ; oboInOwl:id "UBERON:0008597" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "depressor anguli oris muscle" ; rdfs:subClassOf obo:UBERON_0001577, _:genid147421, _:genid147423, _:genid147425 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray381.png"^^xsd:anyURI . obo:UBERON_0008598 obo:IAO_0000115 "Facial muscle that attaches to the fascia of the masseter muscle and the facia of the skin in the region of the corner (angle) of the mouth. Even in species in which this muscle is present, it is highly variable. A true risorius muscle may only be present in Hominins (humans and great apes). See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." ; oboInOwl:hasDbXref "FMA:46838", "MFMO:0000141", "SCTID:244755003", "Wikipedia:Risorius" ; oboInOwl:hasExactSynonym "musculus risorius", "risorius" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008598" ; oboInOwl:inSubset core:feed_aligned, core:human_reference_atlas ; a owl:Class ; rdfs:label "risorius muscle" ; rdfs:subClassOf obo:UBERON_0001577, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011386 ], _:genid147444 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0005467 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000102 ; owl:someValuesFrom obo:UBERON_0008593 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001597 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002097 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Musculusrisorius.png"^^xsd:anyURI . obo:UBERON_0008713 oboInOwl:hasDbXref "EHDAA2:0001421", "EMAPA:17748", "RETIRED_EHDAA2:0001422" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008713" ; a owl:Class ; rdfs:label "pectoral girdle and thoracic body wall skeletal muscle" ; rdfs:subClassOf obo:UBERON_0001134 . obo:UBERON_0008715 obo:IAO_0000115 "A muscle tissue that is part of a prostate gland." ; oboInOwl:hasDbXref "NCIT:C13100", "SCTID:251498008", "UMLS:C1183911" ; oboInOwl:hasExactSynonym "prostate gland muscle tissue", "prostate muscle tissue", "prostatic muscle", "prostatic musclular tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008715" ; a owl:Class ; rdfs:label "muscle tissue of prostate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0008772 obo:IAO_0000115 "A proximal epiphysis that is part of a tibia." ; oboInOwl:hasDbXref "FMA:33113", "NCIT:C32722", "SCTID:302526005", "UMLS:C0932431", "Wikipedia:Upper_extremity_of_tibia" ; oboInOwl:hasExactSynonym "head of tibia", "proximal end of tibia", "proximal tibial epiphysis", "upper end of tibia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008772" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0008775 obo:IAO_0000115 "A proximal epiphysis that is part of a fibula." ; obo:UBPROP_0000001 "The upper extremity or head of the fibula is of an irregular quadrate form, presenting above a flattened articular surface, directed upward, forward, and medialward, for articulation with a corresponding surface on the lateral condyle of the tibia. On the lateral side is a thick and rough prominence continued behind into a pointed eminence, the apex, which projects upward from the posterior part of the head. The prominence, at its upper and lateral part, gives attachment to the tendon of the Biceps femoris and to the fibular collateral ligament of the knee-joint, the ligament dividing the tendon into two parts. The remaining part of the circumference of the head is rough, for the attachment of muscles and ligaments. It presents in front a tubercle for the origin of the upper and anterior fibers of the Peronæus longus, and a surface for the attachment of the anterior ligament of the head; and behind, another tubercle, for the attachment of the posterior ligament of the head and the origin of the upper fibers of the Soleus[Wikipedia:Head_of_fibula]." ; oboInOwl:hasDbXref "EMAPA:37890", "FMA:33729", "NCIT:C32719", "SCTID:182080006", "UMLS:C0223908", "Wikipedia:Head_of_fibula", "galen:HeadOfFibula" ; oboInOwl:hasExactSynonym "caput fibulae", "head of fibula", "proximal end of fibula", "upper end of fibula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibular head" ; oboInOwl:id "UBERON:0008775" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "proximal epiphysis of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0008777 obo:IAO_0000115 "Musculature that is derived from the hypaxial myotome region, trunk muscles that lie ventral to the horizontal septum of the vertebrae. Hypaxial muscles include some vertebral muscles, the diaphragm, the abdominal muscles, and all limb muscles." ; obo:UBPROP_0000001 "Trunk muscle that lies ventral to the horizontal septum of the vertebrae.[AAO]" ; obo:UBPROP_0000008 "The hypaxial muscles are located on the lower side of the body, often below the horizontal septum in many species (primarily fish and amphibians). In amniotes, the positional distinctions have been lost as the body's muscles have changed through evolution, but in all species, the hypaxial muscles are innervated by the ventral ramus of the spinal nerves, while the epaxial muscles are innervated by the dorsal ramus." ; oboInOwl:hasDbXref "AAO:0000228", "EMAPA:37852", "Wikipedia:Epaxial_and_Hypaxial_muscles", "XAO:0003228" ; oboInOwl:hasExactSynonym "hypaxial muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hypaxial muscle" ; oboInOwl:id "UBERON:0008777" ; a owl:Class ; rdfs:label "hypaxial musculature" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/686"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0006838 ], _:genid147484 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003895 ] ) ] . obo:UBERON_0008778 obo:IAO_0000115 "Musculature that is derived from the epaxial myotome region, ventral to the horizontal septum of the vertebrae. Epaxial muscles include other (dorsal) muscles associated with the vertebrae, ribs, and base of the skull." ; obo:UBPROP_0000001 "Trunk muscles that lies dorsal to the horizontal septum.[AAO]", "the muscles derived from the medial myotome; includes the intrinsic back muscles" ; obo:UBPROP_0000008 "In humans, the erector spinae, the transversospinal muscles (including the multifidus, semispinalis and rotatores), the splenius and suboccipital muscles are the only epaxial muscles", "The hypaxial muscles are located on the lower side of the body, often below the horizontal septum in many species (primarily fish and amphibians). In amniotes, the positional distinctions have been lost as the body's muscles have changed through evolution, but in all species, the hypaxial muscles are innervated by the ventral ramus of the spinal nerves, while the epaxial muscles are innervated by the dorsal ramus." ; oboInOwl:hasDbXref "AAO:0000142", "EMAPA:37851", "XAO:0003229" ; oboInOwl:hasExactSynonym "epaxial muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epaxial muscle" ; oboInOwl:id "UBERON:0008778" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epaxial musculature" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0006839 ], _:genid147497 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003900 ] ) ] . obo:UBERON_0008780 obo:IAO_0000115 "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers." ; oboInOwl:hasDbXref "EHDAA2:0000444", "EHDAA:42", "EHDAA:75", "EMAPA:16050", "NCIT:C34164", "UMLS:C1516906" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic epiblast" ; oboInOwl:id "UBERON:0008780" ; oboInOwl:inSubset core:early_development, core:pheno_slim ; a owl:Class ; rdfs:comment "The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5." ; rdfs:label "inner cell mass derived epiblast" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000091 ], _:genid147512 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002532 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000087 ] ) ] . obo:UBERON_0008783 obo:IAO_0000115 "The dorsal venous arch of the foot is a superficial vein that connects the small saphenous vein and the great saphenous vein. Anatomically, it is defined by where the dorsal veins of the first and fifth digit, respectively, meet the great saphenous vein and small saphenous vein." ; oboInOwl:hasDbXref "EMAPA:37521", "FMA:44356", "MA:0002110", "SCTID:231189006", "Wikipedia:Dorsal_venous_arch_of_the_foot" ; oboInOwl:hasExactSynonym "arcus venosus dorsalis pedis", "dorsal venous arch of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcus venosus dorsalis pedis" ; oboInOwl:id "UBERON:0008783" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "dorsal venous arch" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001545 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001547 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001550 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Gray581.png"^^xsd:anyURI . obo:UBERON_0008784 obo:IAO_0000115 "A limb segment that is part of a hindlimb." ; oboInOwl:hasDbXref "FMA:24877" ; oboInOwl:hasExactSynonym "free lower limb segment", "free lower limb subdivision", "segment of free lower limb", "subdivision of free lower limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008784" ; a owl:Class ; rdfs:label "lower limb segment" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0008785 obo:IAO_0000115 "A limb segment that is part of a forelimb." ; oboInOwl:hasDbXref "FMA:24876" ; oboInOwl:hasExactSynonym "free upper limb segment", "free upper limb subdivision", "segment of free upper limb", "subdivision of free upper limb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008785" ; a owl:Class ; rdfs:label "upper limb segment" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0008788 obo:IAO_0000115 "The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE." ; oboInOwl:hasBroadSynonym "posterior fossa" ; oboInOwl:hasDbXref "CALOHA:TS-2354", "FMA:54368", "GAID:85", "MESH:D003388", "NCIT:C33361", "UMLS:C0010265", "Wikipedia:Posterior_cranial_fossa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fossa cranii posterior" ; oboInOwl:id "UBERON:0008788" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior cranial fossa" ; rdfs:subClassOf obo:UBERON_0004704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c2/Posterior_fossa.png"^^xsd:anyURI . obo:UBERON_0008789 obo:IAO_0000115 "Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity." ; obo:IAO_0000116 "todo - review the relationships for this and its subclasses; the relation should be bounded rather than part of, and contains should be used for the brain parts contained by the fossae" ; oboInOwl:hasDbXref "FMA:321144" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008789" ; a owl:Class ; rdfs:label "cranial fossa" ; rdfs:subClassOf _:genid147553 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004704 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ) ] . obo:UBERON_0008801 oboInOwl:hasDbXref "EHDAA2:0001413", "EHDAA:9246" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008801" ; a owl:Class ; rdfs:label "parotid gland primordium" ; rdfs:subClassOf obo:UBERON_0001048 . obo:UBERON_0008803 obo:IAO_0000115 "A zone of skin that is part of a cheek." ; oboInOwl:hasDbXref "FMA:24759", "SCTID:181472009" ; oboInOwl:hasExactSynonym "cheek skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008803" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of cheek" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ] ) ] . obo:UBERON_0008805 obo:IAO_0000115 "The gingival sulcus is an area of potential space between a tooth and the surrounding gingival tissue and is lined by sulcular epithelium. The depth of the sulcus (Latin for groove) is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin." ; oboInOwl:hasDbXref "FMA:74580", "NCIT:C114645", "SCTID:245753001", "Wikipedia:Gingival_sulcus" ; oboInOwl:hasExactSynonym "gingival sulcus", "sulcus gingivalis", "tooth-gingiva interface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sulcus gingivalis" ; oboInOwl:id "UBERON:0008805" ; a owl:Class ; rdfs:label "gingival groove" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000093 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001091 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001828 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5e/Gingival_sulcus.PNG"^^xsd:anyURI . obo:UBERON_0008810 obo:IAO_0000115 "A branch of that maxillary nerve that innervates the mucous membrane of the hard palate." ; oboInOwl:hasDbXref "BAMS:npal", "FMA:52797", "Wikipedia:Nasopalatine_nerve" ; oboInOwl:hasExactSynonym "Scarpa's nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "naso-palatine nerve", "nasopalatine", "nasopalatine nerves", "nervus nasopalatinus" ; oboInOwl:id "UBERON:0008810" ; a owl:Class ; rdfs:label "nasopalatine nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0005046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000377 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Gray858.png"^^xsd:anyURI . obo:UBERON_0008811 obo:IAO_0000115 "An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]." ; obo:IAO_0000232 "this is a broad grouping class connecting a number of different analagous organs by their function. We place the insect aedeagus here rather than penis, although this is somewhat arbitrary given the broadness of the current definition" ; obo:UBPROP_0000001 "Surface structure that is an external structure of a male organism through which sperm is transferred to a female organism during mating.[TAO]" ; oboInOwl:hasDbXref "AAO:0010255", "FBbt:00004850", "HAO:0000091", "TAO:0002036", "TGMA:0000585", "Wikipedia:Intromittent_organ" ; oboInOwl:hasNarrowSynonym "aedeagus", "penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "copulatory organ" ; oboInOwl:id "UBERON:0008811" ; oboInOwl:inSubset core:grouping_class, core:organ_slim ; a owl:Class ; rdfs:label "intromittent organ" ; rdfs:subClassOf obo:UBERON_0003133, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007620 ] . obo:UBERON_0008814 obo:IAO_0000115 "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." ; obo:IAO_0000116 "Currently defined in a vertebrate specific manner. The arch system has origins in basal deuterostomes, consider generalizing" ; oboInOwl:hasDbXref "EHDAA2:0000187", "FMA:293041", "NCIT:C34248", "UMLS:C1519038" ; oboInOwl:hasExactSynonym "embryonic pharyngeal complex", "pharyngeal apparatus", "pharyngeal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngeal arch complex", "pharyngeal arch region", "pharyngeal arches and clefts", "pharyngeal complex" ; oboInOwl:id "UBERON:0008814" ; a owl:Class ; rdfs:label "pharyngeal arch system" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009145 ] . obo:UBERON_0008816 obo:IAO_0000115 "A head that is part of a embryo." ; oboInOwl:hasDbXref "CALOHA:TS-0246", "FBbt:00000155", "FMA:293011" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008816" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "embryonic head" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000033 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:UBERON_0008817 obo:IAO_0000115 "An endoderm that is part of a thymus primordium." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008817" ; a owl:Class ; rdfs:label "thymus primordium endoderm" ; rdfs:subClassOf _:genid147607 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005562 ] ) ] . obo:UBERON_0008823 obo:IAO_0000115 "A brain that develops_from a neural tube." ; obo:IAO_0000116 "a reasoner should automatically classify all the vertebrate ontology brain classes here" ; oboInOwl:hasNarrowSynonym "vertebrate brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008823" ; a owl:Class ; rdfs:label "neural tube derived brain" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/338"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000489, _:genid147615, _:genid147617 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000955 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001049 ] ) ] . obo:UBERON_0008824 obo:IAO_0000115 "Any duct branching of of the main epididymis duct." ; oboInOwl:hasDbXref "EMAPA:36525", "FMA:18297", "MA:0001735", "NCIT:C32484", "SCTID:279623004", "UMLS:C0458632" ; oboInOwl:hasExactSynonym "epididymal duct", "epididymis duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008824" ; a owl:Class ; rdfs:label "duct of epididymis" ; rdfs:subClassOf obo:UBERON_0000058, _:genid147625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:UBERON_0008826 obo:IAO_0000115 "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein)." ; obo:UBPROP_0000009 "surfactant" ; oboInOwl:hasDbXref "EMAPA:36551", "FMA:62780", "MA:0002534", "MESH:D011663", "NCIT:C13273", "UMLS:C0034085", "Wikipedia:Pulmonary_surfactant" ; oboInOwl:hasExactSynonym "alveolar surfactant", "lung surfactant", "type II pneumocyte secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008826" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary surfactant" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_6495 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006538 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:CL_0002063 ] ) ] . obo:UBERON_0008833 obo:IAO_0000115 "A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw." ; oboInOwl:hasDbXref "FMA:6872", "SCTID:181110003", "Wikipedia:Great_auricular_nerve" ; oboInOwl:hasExactSynonym "nervus auricularis magnus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "great auricular", "greater auricular nerve" ; oboInOwl:id "UBERON:0008833" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "great auricular nerve" ; rdfs:subClassOf obo:UBERON_0001021, _:genid147640, _:genid147642 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray805.png"^^xsd:anyURI . obo:UBERON_0008835 obo:IAO_0000115 "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." ; obo:UBPROP_0000008 "in mice, the hepatic diverticulum forms by E9 and expands into an obvious liver bud by E10" ; obo:UBPROP_0000011 "The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut." ; oboInOwl:hasDbXref "AAO:0011057", "EHDAA2:0000740", "EHDAA:1530", "NCIT:C34187", "UMLS:C1512407", "Wikipedia:Hepatic_diverticulum", "XAO:0000101" ; oboInOwl:hasExactSynonym "liver diverticulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diverticulum hepaticum" ; oboInOwl:id "UBERON:0008835" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hepatic diverticulum" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid147650, _:genid147652, _:genid147654 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png"^^xsd:anyURI . obo:UBERON_0008836 oboInOwl:hasDbXref "BTO:0001642" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008836" ; a owl:Class ; rdfs:label "liver bud" ; rdfs:subClassOf obo:UBERON_0007499, _:genid147661, _:genid147663 . obo:UBERON_0008837 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008837" ; a owl:Class ; rdfs:label "palmar/plantar part of autopod" ; rdfs:subClassOf obo:UBERON_0002529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] . obo:UBERON_0008841 obo:IAO_0000115 "A ligament that supports a body part, especially an organ." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008841" ; a owl:Class ; rdfs:label "suspensory ligament" ; rdfs:subClassOf obo:UBERON_0008845 . obo:UBERON_0008842 obo:IAO_0000115 "The cranial atrophic portion of the urogenital ridge attached to the cranial pole of the intraabdominal embryonic testis." ; oboInOwl:hasDbXref "SCTID:279592009", "Wikipedia:Scrotal_ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "scrotal ligament" ; oboInOwl:id "UBERON:0008842" ; a owl:Class ; rdfs:label "suspensory ligament of testis" ; rdfs:subClassOf obo:UBERON_0008841, _:genid147672 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008841 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000473 ] ) ] . obo:UBERON_0008843 obo:IAO_0000115 "The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies." ; obo:UBPROP_0000011 "The upper part of the gubernaculum degenerates; The lower part persists as the gubernaculum testis ('scrotal ligament'). This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis can move within the scrotum[WP]" ; oboInOwl:hasBroadSynonym "gubernaculum" ; oboInOwl:hasDbXref "BTO:0002813", "EMAPA:19089", "FMA:20421", "MA:0003248", "SCTID:299983007" ; oboInOwl:hasExactSynonym "male gubernaculum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Hunter's gubernaculum" ; oboInOwl:id "UBERON:0008843" ; a owl:Class ; rdfs:label "gubernaculum testis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000473 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001300 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004346 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0008844 obo:IAO_0000115 "A gubernaculum that is part of a female reproductive system." ; oboInOwl:hasExactSynonym "female gubernaculum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gubernaculum ovarii" ; oboInOwl:id "UBERON:0008844" ; a owl:Class ; rdfs:comment "The upper part of the gubernaculum, together with the ovarian artery and vein form the suspensory ligament of the ovary,[1] which suspends the ovary from the pelvic wall.; The lower gubernaculum has two vestigial remnants in females, the ovarian ligament and the round ligament of the uterus (ligamentum teres uteri) which respectively serve to support the ovaries and uterus in the pelvis" ; rdfs:label "gubernaculum (female)" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000992 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000995 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004346 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0008845 obo:IAO_0000115 "A ligament that does not connect two skeletal elements." ; obo:UBPROP_0000001 "Ligament organ that primarily consists of dense connective tissue aggregated into fasciculi which may be admixed with smooth muscle. Examples: ligament of liver, ovarian ligament[FMA:25625]." ; obo:UBPROP_0000012 "this class is used more generally than the FMA class, to include for example folds of mesentery such as the broad ligament of the uterus." ; oboInOwl:hasDbXref "FMA:25625", "MA:0003004", "SCTID:410746001" ; oboInOwl:hasExactSynonym "non-skeletal ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibrous ligament" ; oboInOwl:id "UBERON:0008845" ; a owl:Class ; rdfs:label "nonskeletal ligament" ; rdfs:subClassOf obo:UBERON_0000211 ; owl:disjointWith obo:UBERON_0008846 . obo:UBERON_0008846 obo:IAO_0000115 "Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified]." ; obo:IAO_0000116 "logical definition deliberately made strict to avoid classifying MA:spiral ligament as both nonskeletal and skeletal. see https://github.com/obophenotype/mouse-anatomy-ontology/issues/71" ; obo:UBPROP_0000001 "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.[VSAO]", "Ligament organ that primarily consists of regular dense connective tissue aggregated into fasciculi; connects bone and cartilage organs. Examples: sutural ligament, ligament of pinna, tarsal ligament[FMA:25624]." ; oboInOwl:hasBroadSynonym "ligament" ; oboInOwl:hasDbXref "AAO:0010444", "AEO:0000090", "CALOHA:TS-2146", "EHDAA2:0003232", "EV:0100144", "FMA:25624", "GAID:118", "MA:0003005", "SCTID:410744003", "VSAO:0000072", "Wikipedia:Ligament#Articular_ligaments" ; oboInOwl:hasExactSynonym "articular larua", "articular ligament", "true ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008846" ; a owl:Class ; rdfs:label "skeletal ligament" ; rdfs:subClassOf _:genid147704, _:genid147706, _:genid147708, _:genid147710 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004765 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg"^^xsd:anyURI . obo:UBERON_0008854 obo:IAO_0000115 "The part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively." ; oboInOwl:hasDbXref "EMAPA:37948", "FMA:85302" ; oboInOwl:hasExactSynonym "molar root", "molar tooth root" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008854" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "root of molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003677 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0008856 obo:IAO_0000115 "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines." ; obo:UBPROP_0000010 "the muscularis externa in the stomach differs from that of other GI organs in that it has three layers of smooth muscle instead of two" ; oboInOwl:hasDbXref "FMA:14909", "SCTID:362132003" ; oboInOwl:hasExactSynonym "gastric muscularis", "muscle layer of stomach", "muscularis externa of stomach", "tunica muscularis (gaster)", "tunica muscularis gastris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008856" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "stomach muscularis externa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001135 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001167 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001135 ], _:genid147731, _:genid147733 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ] ) ] . obo:UBERON_0008858 obo:IAO_0000115 "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter." ; oboInOwl:hasDbXref "EMAPA:37944", "FMA:14580", "SCTID:245417002", "Wikipedia:Pyloric_canal" ; oboInOwl:hasExactSynonym "canalis pyloricus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canalis pyloricus" ; oboInOwl:id "UBERON:0008858" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pyloric canal" ; rdfs:subClassOf obo:UBERON_0009870, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001202 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001166 ], _:genid147745 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg"^^xsd:anyURI . obo:UBERON_0008861 obo:IAO_0000115 "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." ; obo:IAO_0000116 "check relationship to pylorus vs antrum" ; oboInOwl:hasDbXref "EMAPA:27211", "FMA:14922", "NCIT:C33431", "SCTID:70710007", "UMLS:C0227239", "Wikipedia:Pyloric_gland" ; oboInOwl:hasExactSynonym "glandula pylorica", "pyloric antrum gland", "pyloric gland", "pyloric mucuous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008861" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pyloric gastric gland" ; rdfs:subClassOf obo:UBERON_0000414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004998 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001166 ], _:genid147760, _:genid147762 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000325 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001166 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png"^^xsd:anyURI . obo:UBERON_0008867 obo:IAO_0000115 "The network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force." ; obo:IAO_0000116 "consider revision - we have 3 classes, the tissue itself, the network, and the spaces." ; oboInOwl:hasDbXref "NCIT:C82999", "UMLS:C2826619" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone trabecula", "bone trabeculae" ; oboInOwl:id "UBERON:0008867" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "trabecular network of bone" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002483 ], _:genid147770 . obo:UBERON_0008870 obo:IAO_0000115 "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." ; oboInOwl:hasDbXref "EMAPA:37942" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008870" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary alveolar parenchyma" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0006524 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002299 ] ) ] . obo:UBERON_0008874 obo:IAO_0000115 "The part of the airway consisting of a respiratory bronchiole and all of its branches." ; oboInOwl:hasDbXref "EMAPA:37941", "FMA:7313", "NCIT:C33426", "SCTID:361365004", "UMLS:C0225696", "Wikipedia:Acinus#The_Lungs" ; oboInOwl:hasExactSynonym "acinus pulmonaris", "arbor alveolaris", "lobulus pulmonis primarius", "primary pulmonary lobule", "respiratory lobule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008874" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary acinus" ; rdfs:subClassOf obo:UBERON_0010368 . obo:UBERON_0008876 obo:IAO_0000115 "Any skeletal muscle organ in the hypodermis / superficial fascia." ; obo:IAO_0000116 "We follow MP and treat this as part of the hypodermis, although some sources may consider the hypodermis to be superficial to this" ; oboInOwl:hasAlternativeId "UBERON:0010934" ; oboInOwl:hasDbXref "EMAPA:18188", "MA:0003140" ; oboInOwl:hasExactSynonym "hypodermal muscle layer", "hypodermis muscle layer", "superficial fascia muscular layer" ; oboInOwl:hasNarrowSynonym "panniculus carnosus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008876" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hypodermis skeletal muscle layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002097 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001015 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002072 ], _:genid147796 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0008878 oboInOwl:hasDbXref "FMA:24920", "NCIT:C33252", "UMLS:C0931849", "galen:Palm" ; oboInOwl:hasExactSynonym "front of hand", "palm", "palm of hand", "palmar region", "regio palmaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008878" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "palmar part of manus" ; rdfs:subClassOf obo:UBERON_0005451, obo:UBERON_0008837 . obo:UBERON_0008882 obo:IAO_0000115 "The nerve fiber tracts that span the midline of the spinal cord." ; oboInOwl:hasDbXref "EMAPA:37955" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008882" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "spinal cord commissure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002240 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0008883 obo:IAO_0000115 "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." ; obo:UBPROP_0000001 "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.[VSAO]", "Newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalci[ISBN:0-683-40008-8]n" ; obo:UBPROP_0000012 "Note that in VSAO this was classified both as tissue and acellular extracellular matrix. Consider also the AEO class 'bone condensation'. is_a intercellular matrix in FMA." ; oboInOwl:hasDbXref "EMAPA:37923", "FMA:66830", "NCIT:C33228", "SCTID:39365008", "UMLS:C0682561", "VSAO:0000046", "Wikipedia:Osteoid", "XAO:0004035", "galen:Osteoid" ; oboInOwl:hasExactSynonym "osteoid tissue", "pre-bone", "prebone", "prebone tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008883" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "osteoid" ; rdfs:subClassOf obo:UBERON_0002481 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg"^^xsd:anyURI . obo:UBERON_0008884 obo:IAO_0000115 "A putamen that is part of a left cerebral hemisphere." ; oboInOwl:hasDbXref "FMA:72829", "HBA:4288" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008884" ; a owl:Class ; rdfs:label "left putamen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001874 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 ] ) ] . obo:UBERON_0008885 obo:IAO_0000115 "A putamen that is part of a right cerebral hemisphere." ; oboInOwl:hasDbXref "FMA:72828", "HBA:4289" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008885" ; a owl:Class ; rdfs:label "right putamen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001874 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ] . obo:UBERON_0008886 obo:IAO_0000115 "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." ; obo:UBPROP_0000001 "Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA]" ; oboInOwl:hasDbXref "FMA:45621", "Wikipedia:Pulmonary_circulation" ; oboInOwl:hasExactSynonym "pulmonary circulatory system", "pulmonary system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008886" ; a owl:Class ; rdfs:label "pulmonary vascular system" ; rdfs:subClassOf obo:UBERON_0007798, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002012 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002016 ], _:genid147841 . obo:UBERON_0008887 obo:IAO_0000115 "The hemorrhoidal plexus (or rectal venous plexus) surrounds the rectum, and communicates in front with the vesical venous plexus in the male, and the uterovaginal plexus in the female. A free communication between the portal and systemic venous systems is established through the hemorrhoidal plexus." ; oboInOwl:hasDbXref "FMA:18933", "NCIT:C32728", "SCTID:303051005", "UMLS:C0226766", "Wikipedia:Rectal_venous_plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "haemorrhoidal plexus", "hemorrhoidal plexus", "plexus haemorrhoidalis", "plexus venosus rectalis" ; oboInOwl:id "UBERON:0008887" ; a owl:Class ; rdfs:label "rectal venous plexus" ; rdfs:subClassOf obo:UBERON_0001593 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146119 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray587.png"^^xsd:anyURI . obo:UBERON_0008895 obo:IAO_0000115 "Subdivision of endoskeleton derived from pharyngeal arches." ; obo:UBPROP_0000001 "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO]", "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO]", "The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG]" ; obo:UBPROP_0000003 "The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG]" ; obo:UBPROP_0000012 "VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton.", "many sources define this as the part of the endoskeletal that is from pharyngeal arches - this would make it part-disjoint from dermatocranium. However, there are many bones in AOs that have part-paths to both" ; oboInOwl:hasDbXref "AAO:0010157", "TAO:0001216", "VHOG:0000315", "VSAO:0000149", "Wikipedia:Facial_skeleton", "XAO:0003176", "ZFA:0001216" ; oboInOwl:hasExactSynonym "pharyngeal endoskeleton", "viscerocranium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch skeleton", "gill arch skeleton", "pharyngeal arch", "pharyngeal arch skeleton", "pharyngeal skeleton", "visceral cranium", "visceral skeletal system", "visceral skeleton" ; oboInOwl:id "UBERON:0008895" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "splanchnocranium" ; rdfs:subClassOf obo:UBERON_0011159, _:genid147860, _:genid147862 ; owl:disjointWith obo:UBERON_0011156 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg"^^xsd:anyURI . obo:UBERON_0008896 obo:IAO_0000115 "A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher." ; obo:UBPROP_0000001 "Posterior-most stream of cranial neural crest, which sub-divides during migration.[AAO]" ; oboInOwl:hasDbXref "AAO:0010362", "BTO:0002152", "EFO:0003694", "SCTID:308766004", "TAO:0001597", "XAO:0000099", "ZFA:0001613" ; oboInOwl:hasExactSynonym "branchial arch", "branchial arches", "branchial bar", "branchial bars", "gill arch", "gill arches 1-5", "pharyngeal arch 3-7", "visceral arches 3-7" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gill bar" ; oboInOwl:id "UBERON:0008896" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "post-hyoid pharyngeal arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002539 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000099 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ] . obo:UBERON_0008907 obo:IAO_0000115 "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." ; obo:UBPROP_0000001 "Intramembranous bone that forms superficially in the organism.[TAO]" ; obo:UBPROP_0000012 "other AOs are not yet in sync with this classification" ; oboInOwl:hasDbXref "AAO:0010769", "TAO:0001590", "VSAO:0000130", "Wikipedia:Dermal_bone", "XAO:0004015", "ZFA:0001590" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermal bones" ; oboInOwl:id "UBERON:0008907" ; a owl:Class ; rdfs:label "dermal bone" ; rdfs:subClassOf obo:UBERON_0004756, obo:UBERON_0007842, _:genid147899 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010364 ] ) ] . obo:UBERON_0008909 obo:IAO_0000115 "Bone element that is adjacent to the notochord." ; obo:IAO_0000116 "We go with the latest VSAO in making this a subtype of bone, and add a logical definition based on the textual definition in VSAO. We also include the subtyping under 'replacement bone', for consistency with ZFA" ; obo:UBPROP_0000001 "Replacement bone that forms within the connective tissue surrounding the notochord.[TAO]" ; oboInOwl:hasDbXref "AAO:0010777", "TAO:0001639", "VSAO:0000307", "ZFA:0001629" ; oboInOwl:hasExactSynonym "perichordal bones" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "perichordal bone" ; oboInOwl:id "UBERON:0008909" ; a owl:Class ; rdfs:label "perichordal bone" ; rdfs:subClassOf obo:UBERON_0012075 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002328 ] ) ] . obo:UBERON_0008946 obo:IAO_0000115 "A parenchyma that is part of a lung." ; oboInOwl:hasDbXref "EMAPA:35522", "FMA:27360", "MA:0003168", "SCTID:201712001" ; oboInOwl:hasExactSynonym "respiratory portion of lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parenchyma of lung", "pulmonary parenchyma" ; oboInOwl:id "UBERON:0008946" ; a owl:Class ; rdfs:label "lung parenchyma" ; rdfs:subClassOf obo:UBERON_0000353, _:genid147918 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0008947 oboInOwl:hasDbXref "EHDAA2:0004069", "NCIT:C34283", "UMLS:C1514898" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008947" ; a owl:Class ; rdfs:label "respiratory primordium" ; rdfs:subClassOf obo:UBERON_0001048, _:genid146189, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001004 ] . obo:UBERON_0008962 obo:IAO_0000115 "A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder." ; oboInOwl:hasDbXref "GAID:178", "MESH:D001133", "NCIT:C12983", "SCTID:368532003", "UMLS:C0003793" ; oboInOwl:hasExactSynonym "free forelimb bone" ; oboInOwl:hasNarrowSynonym "wing bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008962" ; a owl:Class ; rdfs:label "forelimb bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010883 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015021 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0008969 obo:IAO_0000115 "A sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively." ; oboInOwl:hasDbXref "BTO:0000337", "EMAPA:35275", "MA:0003121", "NCIT:C34138", "SCTID:110975002", "Wikipedia:Dental_follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dental sac", "tooth follicle" ; oboInOwl:id "UBERON:0008969" ; a owl:Class ; rdfs:label "dental follicle" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008281 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0007002 ], _:genid147939 . obo:UBERON_0008974 obo:IAO_0000115 "Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk." ; obo:UBPROP_0000007 "apocrine" ; obo:UBPROP_0000008 "Mammary glands are modified apocrine glands present in both humans and mice; unlike humans, mice do not have axillary apocrine sweat glands[MGI:anna]" ; oboInOwl:hasDbXref "BTO:0001162", "EMAPA:35141", "MA:0003040", "MESH:D001050", "SCTID:361698000", "Wikipedia:Apocrine" ; oboInOwl:hasExactSynonym "true apocrine gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008974" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim, core:pheno_slim ; a owl:Class ; rdfs:label "apocrine gland" ; rdfs:subClassOf obo:UBERON_0002365 ; owl:disjointWith obo:UBERON_0010243 . obo:UBERON_0008982 obo:IAO_0000115 "A dense regular connective tissue that that connects muscles together[WP, modified]." ; oboInOwl:hasDbXref "BTO:0002930", "EV:0100150", "FMA:30318", "MESH:D005205", "NCIT:C13108", "SCTID:181772008", "UMLS:C0015641", "Wikipedia:Fascia" ; oboInOwl:hasExactSynonym "fascia cluster" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008982" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "fascia" ; rdfs:subClassOf obo:UBERON_0007846, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002204 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0001630 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ], _:genid147948 . obo:UBERON_0008987 obo:IAO_0000115 "The functional tissue of the kidney, consisting of the nephrons." ; oboInOwl:hasDbXref "BTO:0003604", "FMA:15574", "SCTID:29704000" ; oboInOwl:hasExactSynonym "parenchyma of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney parenchyma" ; oboInOwl:id "UBERON:0008987" ; a owl:Class ; rdfs:label "renal parenchyma" ; rdfs:subClassOf obo:UBERON_0000353, _:genid147959 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0008989 obo:IAO_0000115 "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." ; oboInOwl:hasDbXref "BTO:0003634", "FMA:9404", "NCIT:C32536", "SCTID:322749003", "UMLS:C0227178", "Wikipedia:Esophageal_glands" ; oboInOwl:hasExactSynonym "esophageal gland", "glandulae oesophageae", "mucous gland of submucosa of esophagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submocosal esophageal gland" ; oboInOwl:id "UBERON:0008989" ; a owl:Class ; rdfs:label "submucosal esophageal gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001972 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0000912 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg"^^xsd:anyURI . obo:UBERON_0008995 obo:IAO_0000115 "Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii." ; obo:RO_0002175 obo:NCBITaxon_1476529, obo:NCBITaxon_7878, obo:NCBITaxon_7896 ; obo:UBPROP_0000008 "One or more deep cerebellar nuclei appear in agnathans, sharks, ropefishes, lungfishes, Latimeria, and amphibians. Reptiles have two nuclei (a medial and a lateral), and birds and mammals have three nuclei (a medial, a lateral, and an interposed nucleus). The medial nucleus of mammals is known as the fastigial nucleus, and the lateral nucleus is known as the dentate nucleus.[BgeeDb][ISBN:0471888893]" ; oboInOwl:hasDbXref "BTO:0003835", "EMAPA:35272", "FMA:321695", "MA:0000203", "SCTID:279220006" ; oboInOwl:hasExactSynonym "cerebellar nucleus", "deep cerebellar nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008995" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nucleus of cerebellar nuclear complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002037 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 _:genid146240 ) ] . obo:UBERON_0008998 obo:IAO_0000115 "System pertaining to blood vessels in the brain." ; oboInOwl:hasAlternativeId "UBERON:0005284" ; oboInOwl:hasDbXref "BTO:0003840", "EFO:0003491", "EMAPA:35186", "FMA:242007", "FMA:61935", "SCTID:362029003", "TAO:0000099", "ZFA:0000099" ; oboInOwl:hasExactSynonym "brain vasculature", "cerebrovascular system", "intracerebral vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0008998" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "vasculature of brain" ; rdfs:subClassOf obo:UBERON_0002049, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:UBERON_0009002 obo:IAO_0000115 "The membrane separating the fetal from the maternal blood in the placenta." ; oboInOwl:hasDbXref "BTO:0004196", "NCIT:C34253", "SCTID:256591004", "UMLS:C0230984" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "placental barrier" ; oboInOwl:id "UBERON:0009002" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "placental membrane" ; rdfs:subClassOf obo:UBERON_0000158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005292 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid147987 . obo:UBERON_0009010 obo:IAO_0000115 "Any portion of tissue that surrounds a urethra." ; oboInOwl:hasDbXref "BTO:0005081", "SCTID:256880003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009010" ; a owl:Class ; rdfs:label "periurethral tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0009014 obo:IAO_0000115 "A zone of skin that is part of a lower back." ; oboInOwl:hasDbXref "EMAPA:37281", "MA:0000504", "SCTID:286601005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009014" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "lower back skin" ; rdfs:subClassOf obo:UBERON_0003836 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 ] ) ] . obo:UBERON_0009015 obo:IAO_0000115 "A zone of skin that is part of a dorsal thoracic segment of trunk." ; oboInOwl:hasDbXref "EMAPA:37280", "MA:0000510", "SCTID:304890003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009015" ; a owl:Class ; rdfs:label "upper back skin" ; rdfs:subClassOf obo:UBERON_0001418 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008231 ] ) ] . obo:UBERON_0009027 obo:IAO_0000115 "An artery that supplies blood to the urinary bladder." ; oboInOwl:hasDbXref "EMAPA:37131", "MA:0002078", "SCTID:244307000" ; oboInOwl:hasExactSynonym "arteria vesicali", "vesical arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009027" ; a owl:Class ; rdfs:label "vesical artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0009029 obo:IAO_0000115 "Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg." ; oboInOwl:hasDbXref "EMAPA:37184", "MA:0002202", "SCTID:395225000" ; oboInOwl:hasExactSynonym "vena pudendae", "vena pudendales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pudic vein" ; oboInOwl:id "UBERON:0009029" ; a owl:Class ; rdfs:label "pudendal vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] . obo:UBERON_0009030 obo:IAO_0000115 "Vein that drains left lung and returns blood to the heart." ; obo:UBPROP_0000001 "A vein that returns oxygenated blood from the left lung to the left atrium of the heart[ncithesaurus:Left_Pulmonary_Vein]." ; oboInOwl:hasDbXref "EMAPA:37165", "MA:0002207", "NCIT:C48946", "SCTID:304057004", "UMLS:C0226670" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009030" ; a owl:Class ; rdfs:label "left pulmonary vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002016 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0009032 obo:IAO_0000115 "Vein that drains right lung and returns blood to the heart." ; obo:UBPROP_0000001 "A vein that returns oxygenated blood from the right lung to the left atrium of the heart[ncithesaurus:Right_Pulmonary_Vein]." ; oboInOwl:hasDbXref "EMAPA:37379", "MA:0002208", "NCIT:C48947", "SCTID:304056008", "UMLS:C0226669" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009032" ; a owl:Class ; rdfs:label "right pulmonary vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002016 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0009039 obo:IAO_0000115 "A germinal center that is located in a lymph node." ; oboInOwl:hasBroadSynonym "germinal center" ; oboInOwl:hasDbXref "BTO:0003671", "CALOHA:TS-1269", "EMAPA:35528", "MA:0002989", "NCIT:C49757", "SCTID:327147000" ; oboInOwl:hasNarrowSynonym "lymph node light zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph node activated zone", "lymph node central zone", "lymph node nodule" ; oboInOwl:id "UBERON:0009039" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lymph node germinal center" ; rdfs:subClassOf _:genid148048 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_0009042 obo:IAO_0000115 "The prostatic veins form a well-marked prostatic plexus which lies partly in the fascial sheath of the prostate and partly between the sheath and the prostatic capsule. It communicates with the pudendal and vesical plexuses." ; oboInOwl:hasDbXref "FMA:29711", "SCTID:303052003", "Wikipedia:Prostatic_venous_plexus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "plexus venosus prostaticus", "pudendal venous plexus" ; oboInOwl:id "UBERON:0009042" ; a owl:Class ; rdfs:label "prostatic venous plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001593 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png"^^xsd:anyURI . obo:UBERON_0009097 obo:IAO_0000115 "An organism containing a developing embryo, fetus, or unborn offspring within the body." ; oboInOwl:hasDbXref "BTO:0004733" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gravid", "pregnant adult", "pregnant adult stage", "pregnant organism", "pregnant stage" ; oboInOwl:id "UBERON:0009097" ; a owl:Class ; rdfs:label "gravid organism" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0007565 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ] . obo:UBERON_0009098 obo:IAO_0000115 "The uterus in pregnancy." ; oboInOwl:hasDbXref "NCIT:C12406", "SCTID:362253003", "UMLS:C1514389", "ncithesaurus:Gravid_Uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "womb" ; oboInOwl:id "UBERON:0009098" ; a owl:Class ; rdfs:label "gravid uterus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009097 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0007565 ] ; owl:equivalentClass _:genid146329 . obo:UBERON_0009114 obo:IAO_0000115 "A mature thymus that is entirely part of the cervical region." ; obo:RO_0002175 obo:NCBITaxon_39107 ; obo:UBPROP_0000008 "A cervical thymus is a pathological structure in a human - it can form during the migration of the thymus to its location in the mediastinum. Some mice have a cervical thymus. There are examples of cervical thymi in marsupials and prosimians[ISBN:0781714125]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009114" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "cervical thymus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002370 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0009115 obo:IAO_0000115 "A mature thymus that is entirely part of thoracic region." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009115" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "thoracic thymus" ; rdfs:subClassOf _:genid148086 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002370 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ] . obo:UBERON_0009117 obo:IAO_0000115 "A gonad prior to differentiating into a definitive testis or ovary." ; oboInOwl:hasDbXref "EHDAA2:0000716", "NCIT:C34192", "UMLS:C1512703" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gonad rudiment" ; oboInOwl:id "UBERON:0009117" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:comment "typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321]" ; rdfs:label "indifferent gonad" ; rdfs:subClassOf obo:UBERON_0000991, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009196 ] . obo:UBERON_0009122 obo:IAO_0000115 "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary." ; obo:IAO_0000116 "consider adding more detailed spatial placement - e.g. oral ectoderm and/or rostal ectoderm" ; obo:UBPROP_0000011 "Fate-mapping studies in amphibian, chick and mouse embryos (Eagleson et al., 1986; 1995; Couly and Le Douarin, 1985; Cobos et al., 2001; Osumi-Yamachita et al., 1994; Kawamura et al., 2002) have shown that the cells contributing to the adenohypophysis develop at the midline of the anterior neural ridge, which delineates the rostral boundary of the neural plate, a region devoid of neural crest. The anterior neural ridge also gives rise to the olfactory placodes and some forebrain tissues including the olfactory bulbs (reviewed in Papalopulu, 1995). Ablation of this region in chick embryos at the 2-4 somite stage confirmed these lineage analyses as it prevented formation of Rathke's pouch and any further pituitary development (elAmraoui and Dubois, 1993). Upon head folding, the oral ectoderm cells of the adenohypophyseal placode invaginate towards the prospective ventral diencephalon to form Rathke's pouch, the anlage of the adenohypophysis. Rathke's pouch starts as an invagination of the oral ectoderm in response to inductive signals from the prospective diencephalon. The region of the diencephalon above the pouch is known as the infundibulum and forms the posterior lobe of the pituitary or neurohypohysis (Figure 3). While in most basal fish and tetrapods the adenohypophyseal anlagen invaginates to form Rathke's pouch, in teleost fish the adenohypophyseal placode does not invaginate but rather maintains its initial organization forming a solid structure in the head (reviewed in Pogoda and Hammerschmidt; 2009)" ; oboInOwl:hasDbXref "EFO:0000229", "TAO:0001198", "XAO:0004208", "ZFA:0001198" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pituitary placode" ; oboInOwl:id "UBERON:0009122" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "adenohypophyseal placode" ; rdfs:subClassOf obo:UBERON_0002546, obo:UBERON_0011814, _:genid148093 . obo:UBERON_0009124 obo:IAO_0000115 "Rostralmost epibranchial placode. Associated with 1st branchial cleft." ; oboInOwl:hasDbXref "EHDAA2:0004206", "TAO:0001295", "XAO:0004211", "ZFA:0001295" ; oboInOwl:hasExactSynonym "epibranchial placode 1", "facial epibranchial placode", "facial placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial VII placode", "hyoid VII placode", "hyoid placode" ; oboInOwl:id "UBERON:0009124" ; a owl:Class ; rdfs:comment "Taxonomic equivalence to EHDAA2 class made on basis of shared development: gives rise to geniculate ganglion" ; rdfs:label "geniculate placode" ; rdfs:subClassOf obo:UBERON_0003078 . obo:UBERON_0009125 obo:IAO_0000115 "Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft." ; oboInOwl:hasDbXref "EHDAA2:0004207", "TAO:0001296", "XAO:0004212", "ZFA:0001296" ; oboInOwl:hasExactSynonym "epibranchial placode 2", "glossopharyngeal IX placode", "glossopharyngeal epibranchial placode", "glossopharyngeal placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009125" ; a owl:Class ; rdfs:comment "Taxonomic equivalence to EHDAA2 class made on basis of shared development: gives rise to glossopharyngeal ganglion" ; rdfs:label "petrosal placode" ; rdfs:subClassOf obo:UBERON_0003078 . obo:UBERON_0009126 obo:IAO_0000115 "Caudalmost epibranchial placode. Associated with 3rd branchial cleft." ; oboInOwl:hasDbXref "EHDAA2:0004208", "XAO:0004213" ; oboInOwl:hasExactSynonym "epibranchial placode 3", "nodose placode", "nodose placodes", "vagal epibranchial placode", "vagal epibranchial placodes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vagal X placode", "vagal placode" ; oboInOwl:id "UBERON:0009126" ; a owl:Class ; rdfs:comment "Taxonomic equivalence to EHDAA2 class made on basis of shared development: Gives rise to inferior vagus ganglion. Note that ZFA has 4 vagal placodes" ; rdfs:label "nodosal placode" ; rdfs:subClassOf obo:UBERON_0003078 . obo:UBERON_0009127 obo:IAO_0000115 "Cranial ganglion which develops from an epibranchial placode." ; oboInOwl:hasDbXref "TAO:0001555", "ZFA:0001555" ; oboInOwl:hasExactSynonym "epibranchial ganglia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009127" ; a owl:Class ; rdfs:comment "Epibranchial ganglia orchestrate the development of the cranial neurogenic crest" ; rdfs:label "epibranchial ganglion" ; rdfs:subClassOf obo:UBERON_0001714, _:genid148124 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003078 ] ) ] . obo:UBERON_0009129 obo:IAO_0000115 "Endocardium that is part of the right atrium." ; oboInOwl:hasDbXref "EHDAA2:0000274", "FMA:7281", "NCIT:C102339", "SCTID:3194006", "VHOG:0001228" ; oboInOwl:hasExactSynonym "endocardium of right atrium", "right atrial endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right atrium endocardial tissue" ; oboInOwl:id "UBERON:0009129" ; a owl:Class ; rdfs:label "right atrium endocardium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid148133, _:genid148135 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146386 ] . obo:UBERON_0009132 obo:IAO_0000115 "One of a group of three muscles fibularis (peronæus) longus, brevis, and tertius originating on the fibula and inserting on the metatarsals." ; oboInOwl:hasDbXref "EHDAA2:0001450", "EHDAA:8297", "EMAPA:36251", "SCTID:181694005", "Wikipedia:Fibularis_muscles" ; oboInOwl:hasExactSynonym "fibularis", "fibularis muscle", "peroneal muscle", "peroneal muscle group", "peroneal muscles", "peroneus muscle", "peronæus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009132" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "peroneus" ; rdfs:subClassOf obo:UBERON_0001383, _:genid148141, _:genid148143, _:genid148145 . obo:UBERON_0009133 obo:IAO_0000115 "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities." ; obo:UBPROP_0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" ; oboInOwl:hasAlternativeId "UBERON:0009146" ; oboInOwl:hasDbXref "EHDAA2:0001483", "EMAPA:17709", "NCIT:C34256", "SCTID:361429005", "UMLS:C1283968", "VHOG:0000757", "Wikipedia:Pleuroperitoneal" ; oboInOwl:hasExactSynonym "pleuroperitoneal fold", "pleuroperitoneal membranes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009133" ; a owl:Class ; rdfs:label "pleuroperitoneal membrane" ; rdfs:subClassOf obo:UBERON_0000479, obo:UBERON_0002050, _:genid146400, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002402 ] . obo:UBERON_0009139 obo:IAO_0000115 "A posterior cardinal vein that is in_the_right_side_of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasAlternativeId "UBERON:0013123" ; oboInOwl:hasDbXref "EHDAA2:0004536", "FMA:70315", "SCTID:361505001" ; oboInOwl:hasExactSynonym "posterior cardinal vein right", "right postcardinal vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009139" ; a owl:Class ; rdfs:label "right posterior cardinal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002065 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0009141 obo:IAO_0000115 "A vein that is part of a craniocervical region." ; oboInOwl:hasDbXref "EHDAA2:0004542", "SCTID:32945007" ; oboInOwl:hasExactSynonym "craniocervical vein", "head and neck veins", "vein of head and neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009141" ; a owl:Class ; rdfs:label "craniocervical region vein" ; rdfs:subClassOf _:genid148168 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0009142 obo:IAO_0000115 "Sum total of mesenchyme in the embryo." ; obo:IAO_0000116 "consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm)" ; oboInOwl:hasAlternativeId "UBERON:0003313" ; oboInOwl:hasDbXref "EHDAA2:0001113", "EHDAA:177", "EMAPA:16097" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009142" ; a owl:Class ; rdfs:label "entire embryonic mesenchyme" ; rdfs:subClassOf obo:UBERON_0000477, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0003104 ], _:genid148173 . obo:UBERON_0009145 oboInOwl:hasDbXref "EMAPA:16549", "RETIRED_EHDAA2:0001454" ; oboInOwl:hasExactSynonym "pharyngeal region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009145" ; a owl:Class ; rdfs:label "pharyngeal region of foregut" ; rdfs:subClassOf obo:UBERON_0005423, _:genid148177 . obo:UBERON_0009191 obo:IAO_0000115 "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0003446", "EMAPA:18015" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009191" ; a owl:Class ; rdfs:label "sphenoid bone pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0000481, obo:UBERON_0005866, _:genid148186, _:genid148188 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146430 ] . obo:UBERON_0009193 obo:IAO_0000115 "A sphenoid endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001888" ; oboInOwl:hasExactSynonym "sphenoid bone cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009193" ; a owl:Class ; rdfs:label "sphenoid cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009191 ], _:genid148196 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015060 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0009196 oboInOwl:hasDbXref "EHDAA2:0004021" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009196" ; oboInOwl:inSubset core:organ_slim ; a owl:Class ; rdfs:label "indifferent external genitalia" ; rdfs:subClassOf obo:UBERON_0004176, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] . obo:UBERON_0009198 obo:IAO_0000115 "Any suture between cranial and/or facial bones." ; obo:IAO_0000116 "we follow GO in dividing sutures into cranial and facial and making a grouping class, but this is not consistent with FMA" ; oboInOwl:hasExactSynonym "joint of the skull bones" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulation of skull bones" ; oboInOwl:id "UBERON:0009198" ; a owl:Class ; rdfs:label "craniofacial suture" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002209 [ a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:UBERON_0003457 ; owl:onProperty obo:RO_0002176 ] ) ] . obo:UBERON_0009199 obo:IAO_0000115 "Any suture between facial bones." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009199" ; a owl:Class ; rdfs:label "facial suture" ; rdfs:subClassOf obo:UBERON_0009198, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid148216 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009198 _:genid146459 ) ] . obo:UBERON_0009200 obo:IAO_0000115 "The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." ; oboInOwl:hasDbXref "EMAPA:32728" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009200" ; a owl:Class ; rdfs:label "limb epidermis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001003 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0009201 obo:IAO_0000115 "A nephric duct is a tube that drains a primitive kidney[GO]." ; oboInOwl:hasDbXref "EMAPA:16577", "Wikipedia:Wolffian_duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009201" ; a owl:Class ; rdfs:comment "pronephric duct or mesonephric duct" ; rdfs:label "nephric duct" ; rdfs:subClassOf obo:UBERON_0000058, obo:UBERON_0003914, _:genid146472 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0003060 obo:UBERON_0003074 ) ] . obo:UBERON_0009203 obo:IAO_0000115 "A suture joining the nasal bones." ; oboInOwl:hasBroadSynonym "nasal suture" ; oboInOwl:hasDbXref "FMA:52959", "SCTID:368990004", "Wikipedia:Internasal_suture" ; oboInOwl:hasExactSynonym "inter-nasal suture", "internasal suture of skull", "sutura internasalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sutura internasalis" ; oboInOwl:id "UBERON:0009203" ; a owl:Class ; rdfs:label "internasal suture" ; rdfs:subClassOf obo:UBERON_0011160, _:genid148234 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009199 [ a owl:Restriction ; owl:onClass obo:UBERON_0001681 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0009204 obo:IAO_0000115 "Mesenchyme that is part of a medial nasal prominence." ; oboInOwl:hasDbXref "EHDAA2:0001077", "EMAPA:16810", "FMA:312659" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009204" ; a owl:Class ; rdfs:label "medial nasal process mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid148246, _:genid148248 ; owl:disjointWith obo:UBERON_0009205 ; owl:equivalentClass _:genid146485 . obo:UBERON_0009205 obo:IAO_0000115 "Mesenchyme that is part of a lateral nasal prominence." ; oboInOwl:hasDbXref "EHDAA2:0000917", "EMAPA:16807", "FMA:312665" ; oboInOwl:hasExactSynonym "mesenchyme of latero-nasal process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009205" ; a owl:Class ; rdfs:label "lateral nasal process mesenchyme" ; rdfs:subClassOf _:genid148256 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004067 ] ) ] . obo:UBERON_0009206 obo:IAO_0000115 "An ectoderm that is part of a lateral nasal prominence." ; oboInOwl:hasDbXref "EHDAA2:0000918", "EMAPA:16806" ; oboInOwl:hasExactSynonym "ectoderm of latero-nasal process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009206" ; a owl:Class ; rdfs:label "lateral nasal process surface ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, _:genid148265, _:genid148267 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004067 ] ) ] . obo:UBERON_0009210 obo:IAO_0000115 "A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo." ; obo:UBPROP_0000003 "In all vertebrates, the endodermal epithelium lining each pouch contacts the surface ectoderm of the clefts to form a series of bilayered branchial membranes, that break down in fish to form the gill openings.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:32749", "FMA:295758", "NCIT:C34251", "UMLS:C1519040" ; oboInOwl:hasExactSynonym "branchial arch membrane", "branchial membrane", "pharyngeal membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009210" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "each membrane is initially composed of an inner layer formed by the endodermal lining of a branchial pouch and an outer layer formed by the ectodermal lining of the branchial groove; later, these two layers become separated by a thin layer of mesoderm; only the first branchial membrane contributes to the formation of an adult structure, i.e. the tympanic membrane (aka eardrum); the second, third, and fourth membranes are obliterated[MP]" ; rdfs:label "pharyngeal membrane" ; rdfs:subClassOf obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000924 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000925 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0004117 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005879 ], _:genid148271 . obo:UBERON_0009213 obo:IAO_0000115 "A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch." ; obo:IAO_0000116 "check EMAPA - 3 terms appear to match. We follow EMAPA in making each membrane part of the arch with the same number, though in fact it is between these arches" ; oboInOwl:hasDbXref "EHDAA:3788", "EMAPA:16121", "EMAPA:16992", "EMAPA:17281", "VHOG:0001427" ; oboInOwl:hasExactSynonym "1st branchial membrane", "1st pharyngeal membrane", "future tympanic membrane", "tympanic membrane primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009213" ; a owl:Class ; rdfs:label "pharyngeal membrane of 1st arch" ; rdfs:subClassOf obo:UBERON_0009210, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005872 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0007122 ], _:genid148281 . obo:UBERON_0009291 obo:IAO_0000115 "Cartilaginous form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." ; oboInOwl:hasDbXref "SCTID:317278007" ; oboInOwl:hasExactSynonym "cartilaginous centrum of vertebra" ; oboInOwl:hasNarrowSynonym "postcaudal cartilaginous centrum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009291" ; a owl:Class ; rdfs:comment "cartilaginous centrum of vertebra[PMID:11746457]" ; rdfs:label "cartilaginous vertebral centrum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011094 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016491 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0009292 obo:UBPROP_0000012 "medial or lateral; in EHDAA2 also frontonasal or intermaxillary" ; oboInOwl:hasDbXref "EHDAA2:0000581", "EHDAA:4776", "EMAPA:16680", "FMA:293971", "SCTID:308881001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal placode" ; oboInOwl:id "UBERON:0009292" ; a owl:Class ; rdfs:label "embryonic nasal process" ; rdfs:subClassOf obo:UBERON_0012314 . obo:UBERON_0009471 obo:IAO_0000115 "The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis)." ; oboInOwl:hasDbXref "FMA:54651", "NCIT:C32482", "SCTID:66938003", "UMLS:C0226952" ; oboInOwl:hasExactSynonym "dorsal tongue", "dorsum linguae", "tongue dorsum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009471" ; a owl:Class ; rdfs:label "dorsum of tongue" ; rdfs:subClassOf obo:UBERON_0000064, _:genid148298 . obo:UBERON_0009472 obo:IAO_0000115 "The axilla is the area directly under the joint where the forelimb connects to the shoulder." ; obo:UBPROP_0000007 "axillary" ; oboInOwl:hasDbXref "CALOHA:TS-2208", "EFO:0001395", "FMA:24864", "MESH:D001365", "NCIT:C12674", "SCTID:362732006", "UMLS:C0004454", "Wikipedia:Axilla", "galen:Axilla" ; oboInOwl:hasExactSynonym "arm pit", "armpit", "axillary region", "regio axillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "armpits", "axilla", "axillae", "axillary region", "oxter", "underarm" ; oboInOwl:id "UBERON:0009472" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "axilla" ; rdfs:subClassOf obo:UBERON_0034929, _:genid148305 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray411.png"^^xsd:anyURI . obo:UBERON_0009477 obo:IAO_0000115 "Mesenchyme that is part of a otic placode." ; oboInOwl:hasDbXref "EHDAA2:0001340", "EMAPA:16196" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009477" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "associated mesenchyme of otic placode" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003069 ] ) ] . obo:UBERON_0009479 obo:IAO_0000115 "An ectoderm that is part of a buccopharyngeal membrane." ; oboInOwl:hasDbXref "EHDAA2:0000190", "EMAPA:16260" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009479" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "ectoderm of buccopharyngeal membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000924 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006211 ] ) ] . obo:UBERON_0009480 obo:IAO_0000115 "An endoderm that is part of a buccopharyngeal membrane." ; oboInOwl:hasDbXref "EHDAA2:0000191", "EMAPA:16261" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009480" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "endoderm of buccopharyngeal membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006211 ] ) ] . obo:UBERON_0009482 obo:IAO_0000115 "Mesenchyme that is part of a foregut-midgut junction." ; oboInOwl:hasDbXref "EHDAA2:0000570", "EMAPA:16364" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009482" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "associated mesenchyme of foregut-midgut junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 ] ) ] . obo:UBERON_0009483 obo:IAO_0000115 "A mesentery that is part of a foregut-midgut junction." ; obo:UBPROP_0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000575", "EMAPA:16365", "VHOG:0000430" ; oboInOwl:hasExactSynonym "foregut-midgut junction mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009483" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesentery of foregut-midgut junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146576 ] . obo:UBERON_0009494 obo:IAO_0000115 "A portion of mesenchymal tissue associated with an individual pharyngeal arch." ; obo:IAO_0000116 "this represents a part of the entire arch mesenchyme (UBERON:0010046), and is therefore a superclass of the individual arch mesenchyme classes. Alternate definition: primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures." ; oboInOwl:hasDbXref "EMAPA:32755", "FMA:295694" ; oboInOwl:hasExactSynonym "branchial arch mesenchyme", "pharyngeal arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009494" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pharyngeal arch mesenchymal region" ; rdfs:subClassOf obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010046 ], _:genid148353 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid146584 ) ] . obo:UBERON_0009497 obo:IAO_0000115 "An epithelium that is part of a foregut-midgut junction." ; oboInOwl:hasDbXref "EHDAA2:0000573", "EMAPA:16564" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009497" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "epithelium of foregut-midgut junction" ; rdfs:subClassOf obo:UBERON_0000490, _:genid148363, _:genid148365 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 ] ) ] . obo:UBERON_0009500 obo:IAO_0000115 "Anatomical region that surrounds the otic vesicle." ; oboInOwl:hasDbXref "EHDAA2:0001343", "EMAPA:16670", "XAO:0004474" ; oboInOwl:hasExactSynonym "otocyst associated mesenchyme", "otocyst mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "periotic region" ; oboInOwl:id "UBERON:0009500" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "periotic mesenchyme" ; rdfs:subClassOf _:genid148372, _:genid148374 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0003051 ] ) ] . obo:UBERON_0009501 obo:IAO_0000115 "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head." ; oboInOwl:hasDbXref "EHDAA2:0004109", "EMAPA:16683", "FMA:295821" ; oboInOwl:hasExactSynonym "frontonasal mesenchyme", "naso-frontal mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009501" ; oboInOwl:inSubset core:emapa_ehdaa2, core:pheno_slim ; a owl:Class ; rdfs:label "mesenchyme of fronto-nasal process" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004066 ] ) ] . obo:UBERON_0009503 obo:IAO_0000115 "Mesenchyme that is part of a developing hindgut." ; oboInOwl:hasDbXref "EHDAA2:0000780", "EMAPA:16716" ; oboInOwl:hasExactSynonym "hindgut associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009503" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of hindgut" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001046 ] ) ] . obo:UBERON_0009505 obo:IAO_0000115 "Mesenchyme that is part of a developing trachea." ; oboInOwl:hasDbXref "EHDAA2:0002067", "EMAPA:16854" ; oboInOwl:hasExactSynonym "trachea associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009505" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of trachea" ; rdfs:subClassOf obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002539 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ] . obo:UBERON_0009506 obo:IAO_0000115 "Mesenchyme that is part of a developing middle ear." ; obo:UBPROP_0000012 "Also 1st arch maxillary mesenchyme in EHDAA2" ; oboInOwl:hasBroadSynonym "otic mesenchyme" ; oboInOwl:hasDbXref "EHDAA2:0001182", "EMAPA:17001" ; oboInOwl:hasExactSynonym "middle ear associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009506" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of middle ear" ; rdfs:subClassOf obo:UBERON_0007524, _:genid148407, _:genid148409 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] . obo:UBERON_0009521 obo:IAO_0000115 "An endoderm that is part of a anal region." ; oboInOwl:hasDbXref "EHDAA2:0004020", "EMAPA:17177" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009521" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "anal membrane endodermal component" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ) ] . obo:UBERON_0009522 obo:IAO_0000115 "An epithelium that is part of a lateral lingual swelling." ; oboInOwl:hasDbXref "EHDAA2:0000913", "EMAPA:17190", "FMA:313717" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009522" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "lateral lingual swelling epithelium" ; rdfs:subClassOf obo:UBERON_0000490 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006757 ] ) ] . obo:UBERON_0009523 obo:IAO_0000115 "Mesenchyme that is part of a handplate." ; obo:UBPROP_0000012 "We group two EMAPA classes here but these may need to be separated" ; oboInOwl:hasDbXref "EHDAA2:0000731", "EMAPA:17248", "EMAPA:17457" ; oboInOwl:hasExactSynonym "hand plate mesenchyme", "handplate mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009523" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of handplate" ; rdfs:subClassOf _:genid148430 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006875 ] ) ] . obo:UBERON_0009526 obo:IAO_0000115 "Mesenchyme that is part of a maxillary prominence." ; oboInOwl:hasDbXref "EHDAA2:0001071", "EMAPA:17361", "FMA:312691" ; oboInOwl:hasExactSynonym "mesenchyme of maxillary process", "mesenchyme of maxillary prominence" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009526" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "maxillary process mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005868 ] ) ] . obo:UBERON_0009536 obo:IAO_0000115 "A vascular plexus that is part of a left lung." ; oboInOwl:hasDbXref "EHDAA2:0000963", "EMAPA:17660" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009536" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "vascular element of left lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0009537 obo:IAO_0000115 "A vascular plexus that is part of a right lung." ; oboInOwl:hasDbXref "EHDAA2:0001757", "EMAPA:17668" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009537" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "vascular element of right lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005629 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0009538 obo:IAO_0000115 "Mesenchyme that is part of a sublingual gland primordium." ; oboInOwl:hasDbXref "EHDAA2:0001937", "EMAPA:17754" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009538" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of sublingual gland primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003324 ] ; owl:equivalentClass _:genid146679 . obo:UBERON_0009539 obo:IAO_0000115 "Mesenchyme that is part of a submandibular gland primordium." ; oboInOwl:hasDbXref "EHDAA2:0001941", "EMAPA:17757" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submaxillary gland primordium mesenchyme" ; oboInOwl:id "UBERON:0009539" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "mesenchyme of submandibular gland primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003324 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006298 ] ) ] . obo:UBERON_0009548 obo:IAO_0000115 "A hepatic sinusoid that is part of a left lobe of liver." ; oboInOwl:hasDbXref "EHDAA2:0001001", "EMAPA:18309", "VHOG:0000709" ; oboInOwl:hasExactSynonym "left lobe hepatic sinusoids" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009548" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "hepatic sinusoid of left of lobe of liver" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002226 ; owl:someValuesFrom obo:UBERON_0001115 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001281 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001115 ] ) ] . obo:UBERON_0009549 obo:IAO_0000115 "A hepatic sinusoid that is part of a right lobe of liver." ; oboInOwl:hasDbXref "EHDAA2:0001009", "EMAPA:18316", "VHOG:0000710" ; oboInOwl:hasExactSynonym "right lobe hepatic sinusoids" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009549" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "hepatic sinusoid of right of lobe of liver" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002226 ; owl:someValuesFrom obo:UBERON_0001114 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001281 _:genid146701 ) ] . obo:UBERON_0009550 obo:IAO_0000115 "An endoderm that is part of a foregut-midgut junction." ; oboInOwl:hasDbXref "EHDAA2:0000572", "EMAPA:18403" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009550" ; oboInOwl:inSubset core:emapa_ehdaa2 ; a owl:Class ; rdfs:label "endoderm of foregut-midgut junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000925 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 ] ) ] . obo:UBERON_0009551 obo:IAO_0000115 "A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium)." ; obo:UBPROP_0000011 "Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit tips after their amputation through the distal interphalangeal joint. Regeneration of the digit tip involves the integrated regrowth of multiple tissues within 2-3 months, reaching an external morphology that is cosmetically and functionally similar to normal digits. Most importantly, regeneration of the mouse distal digit shares morphological similarities with clinical cases documenting regrowth of missing distal portions of fingers in both children and adults" ; oboInOwl:hasExactSynonym "digit tip", "distal digit segment", "tip of digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009551" ; a owl:Class ; rdfs:label "distal segment of digit" ; owl:equivalentClass _:genid148484 . obo:UBERON_0009552 obo:IAO_0000115 "A segment of the manual digit containing the distal phalanx." ; oboInOwl:hasAlternativeId "UBERON:0004093" ; oboInOwl:hasDbXref "SCTID:312543003" ; oboInOwl:hasExactSynonym "finger digit tip", "finger distal segment", "finger tip", "fingertip", "forelimb digit tip", "tip of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009552" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal segment of manual digit" ; rdfs:subClassOf obo:UBERON_0005451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146724 ] . obo:UBERON_0009553 obo:IAO_0000115 "A segment of the pedal digit containing the distal phalanx. Note this class represents a digit segment and thus includes tissues in addition to bone." ; oboInOwl:hasExactSynonym "hindlimb digit tip", "tip of toe", "toe digit tip", "toe distal segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "P3 segment of pedal digit", "distalmost part of toe" ; oboInOwl:id "UBERON:0009553" ; a owl:Class ; rdfs:label "distal segment of pedal digit" ; rdfs:subClassOf obo:UBERON_0005445 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0009559 obo:IAO_0000115 "A skeletal joint that connects a mesopodium bone and connects a proximal phalanx." ; obo:IAO_0000116 "We include these joints as being part of the digits; this is consistent with the FMA, and makes classification easier. Note that digit and metapodial regions are part-disjoint" ; oboInOwl:hasExactSynonym "metacarpo-tarsophalangeal joint", "metapodial-phalangeal joint", "metapodium-phalanx joint" ; oboInOwl:hasNarrowSynonym "fetlock" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009559" ; a owl:Class ; rdfs:label "metacarpal/tarsal-phalangeal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003656 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004302 ] ) ] . obo:UBERON_0009564 obo:IAO_0000115 "A nail, hoof or claw." ; oboInOwl:hasDbXref "MESH:D006724" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hoof or claw", "hoof, claw or nail", "keratin plate", "keratin sheath", "unguis" ; oboInOwl:id "UBERON:0009564" ; a owl:Class ; rdfs:label "distal limb integumentary appendage" ; rdfs:subClassOf obo:UBERON_0013703, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ], _:genid148532, _:genid148534 . obo:UBERON_0009565 obo:IAO_0000115 "A nail that is part of a manual digit." ; oboInOwl:hasDbXref "EMAPA:35349", "FMA:54327", "NCIT:C32609", "SCTID:244197001", "UMLS:C0222001" ; oboInOwl:hasExactSynonym "finger nail", "fingernail", "nail of finger" ; oboInOwl:hasNarrowSynonym "claw of hand", "claw of manus", "forelimb digit claw", "manual claw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nail plate of finger" ; oboInOwl:id "UBERON:0009565" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of manual digit" ; rdfs:subClassOf _:genid148541, _:genid148543 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ] . obo:UBERON_0009566 obo:IAO_0000115 "A submucosa that is part of a intestine." ; oboInOwl:hasDbXref "FMA:15696" ; oboInOwl:hasExactSynonym "submucosa of intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009566" ; a owl:Class ; rdfs:label "intestinal submucosa" ; rdfs:subClassOf _:genid148559 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146778 ] . obo:UBERON_0009567 obo:IAO_0000115 "A nail that is part of a pedal digit." ; oboInOwl:hasDbXref "EMAPA:36457", "FMA:54328", "NCIT:C33790", "SCTID:244198006", "UMLS:C0222007", "XAO:0003103" ; oboInOwl:hasExactSynonym "nail of pes", "nail of toe", "toe nail", "toenail" ; oboInOwl:hasNarrowSynonym "claw of foot", "claw of pes", "claw of toe", "hindlimb claw", "hindlimb digit claw", "pedal claw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nail plate of toe" ; oboInOwl:id "UBERON:0009567" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of pedal digit" ; rdfs:subClassOf _:genid148567, _:genid148569 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ] . obo:UBERON_0009568 obo:IAO_0000115 "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions." ; obo:UBPROP_0000001 "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" ; oboInOwl:hasDbXref "AAO:0000612", "FMA:72066", "NCIT:C92597", "SCTID:281699004" ; oboInOwl:hasExactSynonym "thoracolumbar column", "thoracolumbar region of vertebral column", "thoracolumbar vertebrae set", "thoracolumbar vertebral column", "trunk vertebrae series", "trunk vertebral column" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presacral region", "thoracolumbar region", "trunk region", "trunk skeleton", "trunk spine" ; oboInOwl:id "UBERON:0009568" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "trunk region of vertebral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0009569 oboInOwl:hasDbXref "FMA:25054", "SCTID:22943007" ; oboInOwl:hasExactSynonym "region of trunk", "trunk subdivision" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009569" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of trunk" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] . obo:UBERON_0009570 obo:IAO_0000115 "A sulcus limitans of neural tube that is part of a future spinal cord." ; oboInOwl:hasDbXref "EHDAA2:0001265", "EMAPA:17584", "VHOG:0001548" ; oboInOwl:hasExactSynonym "spinal cord lateral wall sulcus limitans" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009570" ; a owl:Class ; rdfs:label "spinal cord sulcus limitans" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005478 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006241 ] ) ] . obo:UBERON_0009572 obo:IAO_0000115 "A cerebrospinal fluid-filled space that runs longitudinally through the length of the entire spinal cord. The central canal is contiguous with the ventricular system of the brain. The central canal represents the adult remainder of the neural tube." ; oboInOwl:hasDbXref "EMAPA:25042", "FMA:242845", "Wikipedia:Central_canal" ; oboInOwl:hasExactSynonym "cavity of central canal of spinal cord", "central canal lumen", "spinal cord lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neural lumen" ; oboInOwl:id "UBERON:0009572" ; a owl:Class ; rdfs:label "lumen of central canal of spinal cord" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002291 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001359 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003842 ], _:genid148609 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002291 ] ) ] . obo:UBERON_0009576 obo:IAO_0000115 "A sulcus limitans of neural tube that is part of a future medulla oblongata." ; oboInOwl:hasDbXref "EHDAA2:0001100", "EMAPA:17561" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009576" ; a owl:Class ; rdfs:label "medulla oblongata sulcus limitans" ; rdfs:subClassOf _:genid148621 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005478 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] ) ] . obo:UBERON_0009577 obo:IAO_0000115 "A sulcus limitans of neural tube that is part of a future metencephalon." ; oboInOwl:hasDbXref "EHDAA2:0001161", "EMAPA:17567" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009577" ; a owl:Class ; rdfs:label "metencephalon sulcus limitans" ; owl:equivalentClass _:genid146841 . obo:UBERON_0009578 obo:IAO_0000115 "A sulcus limitans of neural tube that is part of a future myelencephalon." ; oboInOwl:hasDbXref "EHDAA2:0001945" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009578" ; a owl:Class ; rdfs:label "myelencephalon sulcus limitans" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005478 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010096 ] ) ] . obo:UBERON_0009580 oboInOwl:hasDbXref "EHDAA2:0000397", "EMAPA:16906", "VHOG:0000912" ; oboInOwl:hasExactSynonym "diencephalon lateral wall mantle layer", "mantle layer lateral wall diencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009580" ; a owl:Class ; rdfs:label "diencephalon mantle layer" ; owl:equivalentClass _:genid146851 . obo:UBERON_0009581 oboInOwl:hasDbXref "EHDAA2:0001172", "EMAPA:16977", "VHOG:0000910" ; oboInOwl:hasExactSynonym "mantle layer lateral wall midbrain", "midbrain lateral wall mantle layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mantle layer lateral wall mesencephalon" ; oboInOwl:id "UBERON:0009581" ; a owl:Class ; rdfs:label "midbrain mantle layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004061 _:genid146858 ) ] . obo:UBERON_0009583 oboInOwl:hasDbXref "EMAPA:17580", "VHOG:0000911" ; oboInOwl:hasExactSynonym "mantle layer lateral wall spinal cord", "spinal cord lateral wall mantle layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009583" ; a owl:Class ; rdfs:label "spinal cord mantle layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006241 ] ) ] . obo:UBERON_0009584 obo:IAO_0000115 "Mesenchyme that is part of a 1st arch mandibular component." ; oboInOwl:hasAlternativeId "UBERON:0010043" ; oboInOwl:hasDbXref "EHDAA2:0000034", "EMAPA:16385" ; oboInOwl:hasExactSynonym "mesenchymal region of mandibular component of first pharyngeal arch", "mesenchyme of mandibular component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibular component mesenchyme", "mandibular mesenchyme" ; oboInOwl:id "UBERON:0009584" ; a owl:Class ; rdfs:label "1st arch mandibular mesenchyme" ; rdfs:subClassOf _:genid148654 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007237 ] ) ] . obo:UBERON_0009602 obo:IAO_0000115 "Mesenchyme that is part of a developing left lung." ; oboInOwl:hasDbXref "EHDAA2:0000944", "EMAPA:16730", "EMAPA:17654" ; oboInOwl:hasExactSynonym "left lung mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009602" ; a owl:Class ; rdfs:label "left lung associated mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002168 ] ) ] . obo:UBERON_0009603 obo:IAO_0000115 "Mesenchyme that is part of a developing right lung." ; oboInOwl:hasDbXref "EHDAA2:0001739", "EMAPA:17662" ; oboInOwl:hasExactSynonym "right lung mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009603" ; a owl:Class ; rdfs:label "right lung associated mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002167 ] ) ] . obo:UBERON_0009610 obo:IAO_0000115 "A neural plate that develops_from a future forebrain." ; oboInOwl:hasDbXref "TAO:0007018", "ZFA:0007018" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009610" ; a owl:Class ; rdfs:label "forebrain neural plate" ; rdfs:subClassOf _:genid148676 ; owl:equivalentClass _:genid148671 . obo:UBERON_0009611 obo:IAO_0000115 "A neural plate that develops_from a presumptive midbrain." ; oboInOwl:hasDbXref "TAO:0007019", "ZFA:0007019" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009611" ; a owl:Class ; rdfs:label "midbrain neural plate" ; rdfs:subClassOf _:genid148684 ; owl:equivalentClass _:genid148679 . obo:UBERON_0009614 obo:IAO_0000115 "A neural plate that develops_from a presumptive hindbrain." ; oboInOwl:hasDbXref "TAO:0007022", "ZFA:0007022" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009614" ; a owl:Class ; rdfs:label "hindbrain neural plate" ; rdfs:subClassOf _:genid148692 ; owl:equivalentClass _:genid148687 . obo:UBERON_0009615 obo:IAO_0000116 "TODO - developmental relationships for lines" ; oboInOwl:hasDbXref "TAO:0007044", "ZFA:0007044" ; oboInOwl:hasExactSynonym "MHB neural plate", "midbrain-hindbrain boundary neural plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009615" ; a owl:Class ; rdfs:label "midbrain hindbrain boundary neural plate" ; rdfs:subClassOf obo:UBERON_0006598, _:genid148695, _:genid148697 . obo:UBERON_0009616 obo:IAO_0000115 "A presumptive structure that has the potential to develop into a midbrain." ; obo:IAO_0000116 "TODO - unify naming conventions" ; oboInOwl:hasDbXref "BAMS:MES", "EFO:0003432", "EHDAA2:0000615", "EMAPA:16140", "TAO:0000148", "Wikipedia:Mesencephalon", "ZFA:0000148" ; oboInOwl:hasExactSynonym "presumptive mesencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "early midbrain", "future midbrain", "mesencephalon" ; oboInOwl:id "UBERON:0009616" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "presumptive midbrain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003080 ], _:genid148705, _:genid148708 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0009617 obo:IAO_0000115 "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." ; obo:UBPROP_0000011 "A major contributor to neurocranium [PMID:16313393]" ; oboInOwl:hasDbXref "EHDAA2:0000736", "EHDAA:364", "EMAPA:16171" ; oboInOwl:hasExactSynonym "cephalic paraxial mesenchyme", "cephalic paraxial mesoderm", "cranial paraxial mesenchyme", "cranial paraxial mesoderm", "head paraxial mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "somitomere", "somitomeric mesoderm" ; oboInOwl:id "UBERON:0009617" ; a owl:Class ; rdfs:label "head paraxial mesoderm" ; rdfs:subClassOf obo:UBERON_0003104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003077 ], _:genid148716 . obo:UBERON_0009618 oboInOwl:hasDbXref "EHDAA2:0002094" ; oboInOwl:hasExactSynonym "trunk and cervical paraxial mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trunk paraxial mesenchyme" ; oboInOwl:id "UBERON:0009618" ; a owl:Class ; rdfs:label "trunk paraxial mesoderm" ; rdfs:subClassOf obo:UBERON_0003104, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003077 ], _:genid148725 . obo:UBERON_0009621 obo:IAO_0000115 "A somite that is part of a tail." ; oboInOwl:hasDbXref "AAO:0010383", "EMAPA:16860", "XAO:0003143" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009621" ; a owl:Class ; rdfs:label "tail somite" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002329 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002415 ] ) ] . obo:UBERON_0009624 obo:IAO_0000115 "The lumbar nerves are the five spinal nerves emerging from the lumbar vertebrae. They are divided into posterior and anterior divisions." ; oboInOwl:hasDbXref "FMA:5861", "NCIT:C33015", "SCTID:361600002", "UMLS:C0228897", "Wikipedia:Lumbar_nerves", "neuronames:1730" ; oboInOwl:hasExactSynonym "lumbar spinal nerve", "nervus lumbalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi lumbales" ; oboInOwl:id "UBERON:0009624" ; a owl:Class ; rdfs:label "lumbar nerve" ; owl:equivalentClass _:genid146938 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Gray802.png"^^xsd:anyURI . obo:UBERON_0009625 obo:IAO_0000115 "The five sacral nerves emerge from the sacrum. Although the vertebral components of the sacrum are fused into a single bone, the sacral vertebrae are still used to number the sacral nerves. Posteriorly, they emerge from the posterior sacral foramina, and form the posterior branches of sacral nerves. Anteriorly, they emerge from the anterior sacral foramina, and contribute to the sacral plexus (S1-S4) and coccygeal plexus." ; oboInOwl:hasDbXref "FMA:5862", "NCIT:C33505", "SCTID:361601003", "UMLS:C0228922", "Wikipedia:Sacral_nerves", "neuronames:1720" ; oboInOwl:hasExactSynonym "nervus sacralis", "sacral spinal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi sacrales" ; oboInOwl:id "UBERON:0009625" ; a owl:Class ; rdfs:label "sacral nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001780 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0005843 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Gray802.png"^^xsd:anyURI . obo:UBERON_0009636 obo:IAO_0000115 "Chondrocranium chondrification center that that forms anterior body of sphenoid, containing the sella turcica and posterior body of sphenoid." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009636" ; a owl:Class ; rdfs:comment "classified as part of chondrocranium based on developmental relationships" ; rdfs:label "prechordal cartilage" ; rdfs:subClassOf obo:UBERON_0003932 . obo:UBERON_0009638 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "orbitosphenoid center" ; oboInOwl:id "UBERON:0009638" ; a owl:Class ; rdfs:comment "merge with sphenoid lesser wing cartilage element?" ; rdfs:label "orbitosphenoid ossification center" ; rdfs:subClassOf obo:UBERON_0010355 . obo:UBERON_0009639 obo:IAO_0000115 "The body of the sphenoid bone, more or less cubical in shape, is hollowed out in its interior to form two large cavities, the sphenoidal air sinuses, which are separated from each other by a septum." ; oboInOwl:hasDbXref "FMA:52867", "SCTID:140491003", "Wikipedia:Body_of_sphenoid_bone" ; oboInOwl:hasExactSynonym "Entire body of sphenoid bone", "body of sphenoidal bone", "central body of sphenoid", "corpus (os sphenoidale)", "sphenoid body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpus ossis sphenoidalis" ; oboInOwl:id "UBERON:0009639" ; a owl:Class ; rdfs:label "body of sphenoid" ; rdfs:subClassOf obo:UBERON_0001474, _:genid148753, _:genid148755, _:genid148757, _:genid148759, _:genid148761 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d5/Gray146.png"^^xsd:anyURI . obo:UBERON_0009640 obo:IAO_0000115 "Forms around the developing pituitary, and together with prechordal cartilages creates body of sphenoid bone." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009640" ; a owl:Class ; rdfs:comment "classified as part of chondrocranium based on developmental relationships" ; rdfs:label "hypophyseal cartilage" ; rdfs:subClassOf obo:UBERON_0003932 . obo:UBERON_0009644 oboInOwl:hasDbXref "EMAPA:35878", "MA:0001859" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009644" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "trachea non-cartilage connective tissue" ; rdfs:subClassOf obo:UBERON_0003571 . obo:UBERON_0009646 obo:IAO_0000115 "A sympathetic nerve trunk that is part of a lower back." ; oboInOwl:hasDbXref "EMAPA:37655", "FMA:6263", "MA:0001163", "NCIT:C52828", "SCTID:280534006", "UMLS:C1708762" ; oboInOwl:hasExactSynonym "lumbar sympathetic trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lumbar part of sympathetic trunk", "lumbar sympathetic chain" ; oboInOwl:id "UBERON:0009646" ; a owl:Class ; rdfs:label "lumbar sympathetic nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 ] ) ] . obo:UBERON_0009647 obo:IAO_0000115 "One of the two epithelia which make up the tympanic membrane (along with the fibrous layer)." ; oboInOwl:hasDbXref "EMAPA:19064", "MA:0001224", "NCIT:C49308", "SCTID:70839004", "UMLS:C1711401" ; oboInOwl:hasExactSynonym "tympanic epithelium", "tympanic membrane epithelial layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009647" ; a owl:Class ; rdfs:label "tympanic membrane epithelium" ; rdfs:subClassOf obo:UBERON_0010071 ; owl:disjointWith obo:UBERON_0010070 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002364 ] ) ] . obo:UBERON_0009648 obo:IAO_0000115 "An eyelid connective tissue that is part of a hypodermis." ; oboInOwl:hasDbXref "EMAPA:37533", "FMA:63975", "MA:0001252", "NCIT:C49226", "UMLS:C1707991" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "superficial fascia of eyelid" ; oboInOwl:id "UBERON:0009648" ; a owl:Class ; rdfs:label "eyelid subcutaneous connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001457 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003581 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0009651 obo:IAO_0000115 "A basement membrane that is part of a nephron tubule." ; oboInOwl:hasDbXref "EMAPA:37490", "MA:0001680", "NCIT:C49273", "SCTID:245251000", "UMLS:C1709901" ; oboInOwl:hasExactSynonym "kidney tubule basement membrane", "renal tubular basement membrane", "renal tubule basement membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009651" ; a owl:Class ; rdfs:label "nephron tubule basement membrane" ; rdfs:subClassOf _:genid148801, _:genid148803 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid146997 ] . obo:UBERON_0009652 obo:IAO_0000115 "A basement membrane that is part of a bronchus." ; obo:UBPROP_0000012 "MA classifies as type of connective tissue: https://github.com/obophenotype/mouse-anatomy-ontology/issues/108" ; oboInOwl:hasDbXref "EMAPA:37809", "MA:0001832", "NCIT:C49208", "UMLS:C1707051" ; oboInOwl:hasExactSynonym "bronchial basement membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009652" ; a owl:Class ; rdfs:label "bronchus basement membrane" ; rdfs:subClassOf _:genid148814 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0009653 obo:IAO_0000115 "A basement membrane that is part of a trachea." ; oboInOwl:hasDbXref "EMAPA:37552", "MA:0001854", "NCIT:C49302", "UMLS:C1710455" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009653" ; a owl:Class ; rdfs:label "trachea basement membrane" ; rdfs:subClassOf _:genid148825, _:genid148827 ; owl:equivalentClass _:genid147017 . obo:UBERON_0009654 obo:IAO_0000115 "A branch of the maxillary artery that is found in the gingiva, premolars, and molars." ; obo:IAO_0000116 "add child terms" ; oboInOwl:hasDbXref "EMAPA:37069", "MA:0001913", "NCIT:C52848", "UMLS:C1706783" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009654" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "alveolar artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 ] . obo:UBERON_0009655 obo:IAO_0000115 "An artery that supplies oxygenated blood to the ear." ; obo:IAO_0000116 "add child terms" ; oboInOwl:hasDbXref "EMAPA:37072", "MA:0001918", "NCIT:C52849", "UMLS:C1706858" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009655" ; a owl:Class ; rdfs:label "auricular artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_0009657 oboInOwl:hasBroadSynonym "labial artery" ; oboInOwl:hasDbXref "EMAPA:37092", "MA:0001987", "NCIT:C52947", "UMLS:C1708633" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009657" ; a owl:Class ; rdfs:label "artery of lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0009661 obo:IAO_0000115 "Nucleus located in the midbrain." ; oboInOwl:hasDbXref "SCTID:279285003", "TAO:0002209", "ZFA:0001665" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009661" ; a owl:Class ; rdfs:label "midbrain nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0009662 obo:IAO_0000115 "Nucleus located within the hindbrain." ; oboInOwl:hasDbXref "TAO:0002177", "ZFA:0001658" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009662" ; a owl:Class ; rdfs:label "hindbrain nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0009663 obo:IAO_0000115 "A nucleus of brain that is part of a telencephalon." ; oboInOwl:hasDbXref "TAO:0002178", "ZFA:0001660" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009663" ; a owl:Class ; rdfs:label "telencephalic nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid147057 ] . obo:UBERON_0009664 oboInOwl:hasDbXref "EHDAA2:0004566", "EMAPA:32911", "MA:0003203" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "peritoneal cavity mesentary", "peritoneal mesentary" ; oboInOwl:id "UBERON:0009664" ; a owl:Class ; rdfs:label "gut mesentery" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/509"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0002095, _:genid148867 . obo:UBERON_0009668 obo:IAO_0000115 "Ventral mesentery is the part of the peritoneum closest to the navel." ; obo:UBPROP_0000011 "degenerates during development except foregut portion" ; oboInOwl:hasDbXref "EHDAA2:0004569", "SCTID:361430000", "Wikipedia:Ventral_mesentery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009668" ; a owl:Class ; rdfs:label "ventral mesentery" ; rdfs:subClassOf obo:UBERON_0002050, _:genid148871 . obo:UBERON_0009669 obo:IAO_0000115 "An anatomical space that surrounded_by a embryonic cloaca." ; oboInOwl:hasDbXref "EHDAA2:0004586" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009669" ; a owl:Class ; rdfs:label "embryonic cloacal lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000163 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0009846 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000163 ] ) ] . obo:UBERON_0009670 obo:IAO_0000115 "An anatomical space that surrounded_by a rectum." ; oboInOwl:hasDbXref "EHDAA2:0004587", "EMAPA:18388", "FMA:14598", "SCTID:259740004" ; oboInOwl:hasExactSynonym "lumen of rectum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009670" ; a owl:Class ; rdfs:label "rectal lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ], _:genid148886, _:genid148888 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0009676 oboInOwl:hasDbXref "EFO:0003562", "EHDAA2:0001981", "EHDAA:1993", "EHDAA:2671", "EMAPA:16914" ; oboInOwl:hasExactSynonym "early telencephalic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "early telencephalic ventricle" ; oboInOwl:id "UBERON:0009676" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "early telencephalic vesicle" ; rdfs:subClassOf obo:UBERON_0013150, _:genid148892, _:genid148894 . obo:UBERON_0009678 obo:IAO_0000115 "Anatomical cluster consisting of adjacent teeth constituting a row." ; oboInOwl:hasDbXref "FMA:59415", "TAO:0001667", "ZFA:0001642" ; oboInOwl:hasExactSynonym "dental arcade", "row of teeth", "tooth rows" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009678" ; a owl:Class ; rdfs:label "tooth row" ; rdfs:subClassOf obo:UBERON_0003672 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034926 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0001091 ] ) ] . obo:UBERON_0009679 obo:IAO_0000115 "A tooth row that is part of a skeleton of lower jaw." ; oboInOwl:hasDbXref "EHDAA2:0001029", "FMA:55635" ; oboInOwl:hasExactSynonym "arcus dentalis inferior", "lower dental arcade", "lower jaw teeth", "set of all lower teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibular dental arcade" ; oboInOwl:id "UBERON:0009679" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "set of lower jaw teeth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009678 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003278 ] ) ] . obo:UBERON_0009680 obo:IAO_0000115 "A tooth row that is part of a skeleton of upper jaw." ; oboInOwl:hasDbXref "EHDAA2:0002129", "FMA:55634" ; oboInOwl:hasExactSynonym "arcus dentalis superior", "set of all upper teeth", "upper dental arcade", "upper jaw teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillary dental arcade" ; oboInOwl:id "UBERON:0009680" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "set of upper jaw teeth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009678 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 ] ) ] . obo:UBERON_0009692 obo:IAO_0000115 "An organ cavity that is part of a pharyngotympanic tube." ; obo:IAO_0000116 "Check relationships for conformance with AAO and XAO" ; oboInOwl:hasDbXref "EHDAA2:0004118", "FMA:60079" ; oboInOwl:hasExactSynonym "auditory tube lumen", "lumen of auditory tube", "lumen of eustachian tube", "pharyngotympanic tube lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009692" ; a owl:Class ; rdfs:label "lumen of pharyngotympanic tube" ; rdfs:subClassOf obo:UBERON_0005082, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0010060 ], _:genid148931, _:genid148933 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 ] ) ] . obo:UBERON_0009695 obo:IAO_0000115 "An epithelium that is part of a hypopharynx." ; oboInOwl:hasDbXref "EHDAA2:0004575", "FMA:62454" ; oboInOwl:hasExactSynonym "epithelium of laryngeal pharynx", "laryngopharynx epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009695" ; a owl:Class ; rdfs:label "epithelium of laryngopharynx" ; rdfs:subClassOf _:genid148944, _:genid148946, _:genid148948 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 ] ) ] . obo:UBERON_0009708 oboInOwl:hasDbXref "EHDAA2:0001371" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreatis dorsalis" ; oboInOwl:id "UBERON:0009708" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim ; a owl:Class ; rdfs:label "dorsal pancreas" ; rdfs:subClassOf obo:UBERON_0002365, _:genid148954, _:genid148956, _:genid148958 . obo:UBERON_0009709 oboInOwl:hasDbXref "EHDAA2:0001393" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pancreatis ventralis" ; oboInOwl:id "UBERON:0009709" ; oboInOwl:inSubset core:human_reference_atlas, core:organ_slim ; a owl:Class ; rdfs:label "ventral pancreas" ; rdfs:subClassOf obo:UBERON_0002365, _:genid148961, _:genid148963, _:genid148965 . obo:UBERON_0009712 obo:IAO_0000115 "Any endocardium that is part of the right ventricle of the heart." ; obo:UBPROP_0000001 "Endocardium of ventricle which is continuous tricuspid valve, pulmonary valve and with the tunica intima of the pulmonary trunk." ; oboInOwl:hasDbXref "EHDAA2:0002188", "EMAPA:17341", "FMA:9536", "NCIT:C102343", "SCTID:8911002", "VHOG:0001235" ; oboInOwl:hasExactSynonym "right ventricle endocardium", "right ventricular endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "endocardial lining of right ventricle", "right ventricle endocardial tissue" ; oboInOwl:id "UBERON:0009712" ; a owl:Class ; rdfs:label "endocardium of right ventricle" ; rdfs:subClassOf _:genid148971, _:genid148973 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001081 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0009713 obo:IAO_0000115 "Any endocardium that is part of the left ventricle of the heart." ; obo:UBPROP_0000001 "Endocardium of ventricle which is continuous with mitral valve, aortic valve, atrioventricular septum and the tunica intima of the aorta." ; oboInOwl:hasDbXref "EHDAA2:0002182", "EMAPA:17338", "FMA:9559", "SCTID:191004004", "VHOG:0001233" ; oboInOwl:hasExactSynonym "left ventricle endocardium", "left ventricular endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "endocardial lining of left ventricle", "left ventricle endocardial tissue" ; oboInOwl:id "UBERON:0009713" ; a owl:Class ; rdfs:label "endocardium of left ventricle" ; rdfs:subClassOf _:genid148985 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001081 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0009714 obo:IAO_0000115 "The primordial mass of tissue formed by the merging of the medial nasal prominences of the embryo; it contributes to the intermaxillary portion of the upper jaw, the prolabial portion of the upper lip, and the primary palate." ; obo:IAO_0000116 "requires verification. Note EHDAA2 has this as coming from both lateral and medial prominences. See also: median cleft lip" ; oboInOwl:hasDbXref "EHDAA2:0000868", "EHDAA:7856", "FMA:295872", "Wikipedia:Intermaxillary_segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "globular process", "globular processes of his", "intermaxillary segment" ; oboInOwl:id "UBERON:0009714" ; a owl:Class ; rdfs:label "intermaxillary process" ; rdfs:subClassOf obo:UBERON_0009292, _:genid148994, _:genid148996 . obo:UBERON_0009715 obo:IAO_0000115 "An anatomical cavity that surrounded_by a stomodeum." ; oboInOwl:hasExactSynonym "lumen of stomatodaeum", "lumen of stomodeum", "stomatodeal cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009715" ; a owl:Class ; rdfs:label "stomodeal lumen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000930 ] ) ] . obo:UBERON_0009722 oboInOwl:hasDbXref "EHDAA2:0004621", "EMAPA:32754", "FMA:293087" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngeal arch endoderm" ; oboInOwl:id "UBERON:0009722" ; a owl:Class ; rdfs:label "entire pharyngeal arch endoderm" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008814 ], _:genid149007, _:genid149010 . obo:UBERON_0009744 obo:IAO_0000115 "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels." ; oboInOwl:hasBroadSynonym "medullary sinus" ; oboInOwl:hasDbXref "EMAPA:37898", "FMA:312359" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph node medullary sinusoid" ; oboInOwl:id "UBERON:0009744" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:comment "Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells.[WP]" ; rdfs:label "lymph node medullary sinus" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ], [ a owl:Restriction ; owl:onProperty core:channel_for ; owl:someValuesFrom obo:UBERON_0002391 ] . obo:UBERON_0009745 obo:IAO_0000115 "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node." ; oboInOwl:hasBroadSynonym "medullary cord" ; oboInOwl:hasDbXref "EMAPA:37897" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009745" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lymph node medullary cord" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0009744 ] . obo:UBERON_0009749 obo:IAO_0000115 "The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells." ; obo:UBPROP_0000012 "EMAPA mapping from TH" ; oboInOwl:hasDbXref "EMAPA:32705" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "limb mesoderm" ; oboInOwl:id "UBERON:0009749" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "limb mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0009751 obo:IAO_0000115 "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." ; obo:IAO_0000116 "decide whether to merge with cardiac mesoderm. In EHDAA2 this lasts CS12->unbounded, includes mesenchyme of individual components as parts" ; oboInOwl:hasDbXref "EHDAA2:0004162", "EMAPA:36438" ; oboInOwl:hasExactSynonym "heart mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009751" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cardiac mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0009752 obo:IAO_0000115 "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." ; oboInOwl:hasDbXref "EFO:0002557", "EMAPA:26220" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009752" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "pancreas mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0009758 obo:IAO_0000115 "A ganglion that is part of a abdominal segment of trunk." ; oboInOwl:hasDbXref "SCTID:280508003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009758" ; a owl:Class ; rdfs:label "abdominal ganglion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0009767 obo:IAO_0000115 "An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx." ; oboInOwl:hasDbXref "FMA:65022", "NCIT:C101528" ; oboInOwl:hasNarrowSynonym "PIJ joint", "PIP joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009767" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal interphalangeal joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004301 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006658 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004302 ] ) ] . obo:UBERON_0009768 obo:IAO_0000115 "An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx." ; oboInOwl:hasDbXref "FMA:65024", "NCIT:C101529" ; oboInOwl:hasNarrowSynonym "DIJ joint", "DIP joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009768" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006658 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004300 ] ) ] . obo:UBERON_0009773 obo:IAO_0000115 "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." ; obo:IAO_0000232 "this class groups vertebrate nephron tubules with analagous structures such as insect Malpighian tubules" ; oboInOwl:hasExactSynonym "renal tubule (generic)", "tubule of excretory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009773" ; oboInOwl:inSubset core:grouping_class, core:pheno_slim ; a owl:Class ; rdfs:label "renal tubule" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 ] . obo:UBERON_0009778 obo:IAO_0000115 "A serous sac that has the pleura and the pleural cavity as parts." ; obo:UBPROP_0000012 "despite its name the class EHDAA2:0004737 is not a true cavity, it corresponds to what we call the sac" ; oboInOwl:hasDbXref "EHDAA2:0004737", "FMA:9690", "SCTID:361996004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009778" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "pleural sac" ; rdfs:subClassOf _:genid149069, _:genid149071 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005906 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000977 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002402 ] ) ] . obo:UBERON_0009842 obo:IAO_0000115 "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." ; obo:UBPROP_0000007 "acinar" ; oboInOwl:hasBroadSynonym "acinus" ; oboInOwl:hasDbXref "FMA:55588", "Wikipedia:Acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acini" ; oboInOwl:id "UBERON:0009842" ; a owl:Class ; rdfs:label "glandular acinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034922 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002530 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000151 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002422 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png"^^xsd:anyURI . obo:UBERON_0009843 obo:IAO_0000115 "A solid cord of prostate epithelium." ; oboInOwl:hasExactSynonym "cord of prostate epithelium", "epithelial cord of prostate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009843" ; a owl:Class ; rdfs:comment "Complexity is conferred on the prostate during a postnatal development phase known as branching morphogenesis. Solid cords of prostate epithelium formed in utero elongate postnatally and their tips are bifurcated into primary, secondary, and tertiary branches in a pattern that is unique for each prostate lobe. Branching morphogenesis proceeds differentially for each of the three mouse prostate lobes (ventral, dorsolateral, and anterior) and is completed by about postnatal day 20 in mice, providing each lobe with unique glandular architecture [5]. It is important to note that the developing human prostate undergoes a similar series of morphogenetic events especially during prostatic bud formation, but gives rise to a mature glandular prostate that is unique from the rodent and features peripheral, central, and transitional zones[PMID:18977204]" ; rdfs:label "prostate epithelial cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid147255 ] . obo:UBERON_0009844 obo:IAO_0000115 "An anatomical space that surrounded_by a primitive urogenital sinus." ; oboInOwl:hasDbXref "EHDAA2:0002142" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009844" ; a owl:Class ; rdfs:label "urogenital sinus lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000164 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0004902 ], _:genid149097 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000164 ] ) ] . obo:UBERON_0009845 obo:IAO_0000115 "Mesenchyme that surrounds primitive urogenital sinus." ; obo:UBPROP_0000011 "Androgen receptor (AR) activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth" ; oboInOwl:hasDbXref "EMAPA:31500" ; oboInOwl:hasExactSynonym "UGM" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009845" ; a owl:Class ; rdfs:label "urogenital sinus mesenchyme" ; owl:equivalentClass _:genid149101 . obo:UBERON_0009846 obo:IAO_0000115 "An epithelium that is part of a embryonic cloaca." ; oboInOwl:hasBroadSynonym "cloacal epithelium" ; oboInOwl:hasDbXref "EHDAA2:0004585" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009846" ; a owl:Class ; rdfs:label "embryonic cloacal epithelium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid149113, _:genid149115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000163 ] ) ] . obo:UBERON_0009847 obo:IAO_0000115 "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prostate primordium" ; oboInOwl:id "UBERON:0009847" ; a owl:Class ; rdfs:label "prostate field" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid149124, _:genid149126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007688 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0009854 obo:IAO_0000115 "Branch or outpocketing of the digestive tract." ; oboInOwl:hasDbXref "FBbt:00100316" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diverticulum of gut", "intestinal pouch" ; oboInOwl:id "UBERON:0009854" ; a owl:Class ; rdfs:label "digestive tract diverticulum" ; rdfs:subClassOf obo:UBERON_0004921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid147292 ] . obo:UBERON_0009856 oboInOwl:hasDbXref "galen:Diverticulum" ; oboInOwl:hasExactSynonym "pouch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diverticulum" ; oboInOwl:id "UBERON:0009856" ; a owl:Class ; rdfs:label "sac" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001987 ] ) ] . obo:UBERON_0009857 obo:IAO_0000115 "A space enclosed within the laminae of the septum pelludicum, the membranous partition that seperates the frontal horns of the ventricle. contains cerebrospinal fluid (CSF) that filters from the ventricles through the septal laminae. bounded anteriorly by the genu of the corpus callosum; superiorly by the body of the corpus callosum; posteriorly by the anterior limb and pillars of the fornix; inferiorly by the anterior commissure and the rostrum of the corpus callosum; and laterally by the leaflets of the septum pellucidum." ; obo:UBPROP_0000008 "In humans, present in 100% of fetuses, but over 85% of them fuse by 3-6 months after birth" ; oboInOwl:hasDbXref "BAMS:CSP", "BTO:0003447", "DHBA:12099", "FMA:61874", "NCIT:C32602", "SCTID:180933005", "UMLS:C0228158", "Wikipedia:Cave_of_septum_pellucidum", "neuronames:257" ; oboInOwl:hasExactSynonym "cave of septum pellucidum", "cavum of septum pellucidum", "septum pellucidum cave", "ventriculus septi pellucidi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavum septi pellucidi", "fifth ventricle" ; oboInOwl:id "UBERON:0009857" ; a owl:Class ; rdfs:label "cavum septum pellucidum" ; rdfs:subClassOf _:genid147305, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002742 ] ; owl:equivalentClass _:genid147301 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/CavumSeptumPellucidumDiagram.jpg"^^xsd:anyURI . obo:UBERON_0009859 obo:IAO_0000115 "A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones." ; obo:UBPROP_0000007 "endosteal" ; oboInOwl:hasDbXref "FMA:32692", "NCIT:C13183", "SCTID:57487002", "UMLS:C0222658", "Wikipedia:Endosteum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009859" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "endosteum" ; rdfs:subClassOf obo:UBERON_0000158, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002484 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011825 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg"^^xsd:anyURI . obo:UBERON_0009870 obo:IAO_0000115 "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." ; obo:IAO_0000116 "We follow Kardong in defining stomach regions by gland, but we also include 'body of stomach'. In future we may want to have different partitions of the stomach" ; oboInOwl:hasAlternativeId "UBERON:0009034" ; oboInOwl:hasDbXref "EMAPA:35821", "FMA:14558", "MA:0002561", "SCTID:245415005", "Wikipedia:Stomach#Sections" ; oboInOwl:hasExactSynonym "gastric zone", "region of stomach", "section of stomach" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009870" ; a owl:Class ; rdfs:label "zone of stomach" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid147321 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg"^^xsd:anyURI . obo:UBERON_0009871 obo:IAO_0000115 "Outer portion of the renal cortex. Site of formation of medullary and cortical elements." ; obo:UBPROP_0000008 "see http://www.ncbi.nlm.nih.gov/pubmed/12761251 for description of nephrogenic zone in dogfish." ; oboInOwl:hasDbXref "EMAPA:27721", "MA:0002996", "http://www.gudmap.org/Images/Organ_Summaries/Metanephros/NZ.png" ; oboInOwl:hasExactSynonym "cortical nephrogenic niche", "cortical nephrogenic zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nephrogenic tissue" ; oboInOwl:id "UBERON:0009871" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nephrogenic zone" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 ] . obo:UBERON_0009877 obo:IAO_0000115 "Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region." ; obo:IAO_0000116 "considering adding 'acropodial region'" ; obo:UBPROP_0000013 "Naming conventions for pod terms under discussion within phenoscape group" ; oboInOwl:hasDbXref "SCTID:370640001" ; oboInOwl:hasExactSynonym "metacarpal or metatarsal part of limb", "metacarpus/metatarsus region", "metapodial segment" ; oboInOwl:hasNarrowSynonym "cannon region", "equine cannon region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metacarpus/metatarsus", "metapodium" ; oboInOwl:id "UBERON:0009877" ; a owl:Class ; rdfs:label "metapodium region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0006716 ], _:genid149173, _:genid149175 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002529 _:genid147333 ) ] . obo:UBERON_0009878 obo:IAO_0000115 "The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton." ; obo:UBPROP_0000001 "Limb skeleton subdivision consisting of endochondral bones increasing the freedom of movement of the autopodia, and located between zeugopodia and autopodia.[VSAO]" ; obo:UBPROP_0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" ; oboInOwl:hasDbXref "VSAO:0005022" ; oboInOwl:hasExactSynonym "basipodium skeleton", "carpal/tarsal skeleton", "mesopodial skeleton", "mesopodium skeleton", "skeletal parts of mesopodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basipodium", "mesopodium" ; oboInOwl:id "UBERON:0009878" ; a owl:Class ; rdfs:label "mesopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006716 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006717 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0010546 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0011584 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0006716 ] ) ] . obo:UBERON_0009879 obo:IAO_0000115 "Subdivision of skeleton that consists of endochondral elements distal to the zeugopodial skeletal elements which constitute the proximal region of the posterior autopod skeleton[PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "Segment of the leg corresponding to the tarsus. It consists of several elements that articulate with the tibia and fibula at one end and the metatarsals at the other end.[AAO]" ; obo:UBPROP_0000003 "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" ; obo:UBPROP_0000008 "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present" ; obo:UBPROP_0000012 "we assume MA:tarsus belongs here, as there is a distinct class MA:ankle, with the tarsal bone being part of the former. XAO:tarsus is part of the hindlimb skeleton. FMA set-of class lacks definition but we assume this to be equivalent." ; oboInOwl:hasDbXref "AAO:0000220", "EMAPA:19133", "FMA:71339", "GAID:1223", "MA:0000050", "SCTID:264228001", "SCTID:361796005", "VHOG:0001160", "VSAO:0005024", "Wikipedia:Tarsus_(skeleton)", "XAO:0003211" ; oboInOwl:hasExactSynonym "hind mesopodial skeleton", "hind mesopodium", "hind mesopodium skeleton", "set of tarsal bones", "skeletal parts of hind mesopodium", "tarsal bones set", "tarsalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basipodium", "mesopodium", "tarsal bones", "tarsus" ; oboInOwl:id "UBERON:0009879" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tarsal skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001445 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0010545 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0010720 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] . obo:UBERON_0009880 obo:IAO_0000115 "Subdivision of skeleton that consists of the endochondral elements distal to the anterior limb/fin zeugopodial skeletal elements which constitute the proximal region of the anterior autopod skeleton[PHENOSCAPE:ad]." ; obo:UBPROP_0000001 "Segment of the forearm corresponding to the carpus. It consists of several elements that articulate with the radius and ulna at one end and the metacarpals at the other end.[AAO]" ; obo:UBPROP_0000003 "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" ; obo:UBPROP_0000008 "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present[PHENOSCAPE:ad].", "The structure of the carpus varies widely between different groups of tetrapods, even among those that retain the full set of five digits. In primitive fossil amphibians, such as Eryops, the carpus consists of three rows of bones; a proximal row of three carpals, a second row of four bones, and a distal row of five bones. The proximal carpals are referred to as the radiale, intermediale, and ulnare, after their proximal articulations, and are homologous with the scaphoid, lunate, and triquetal bones respectively. The remaining bones are simply numbered, as the first to fourth centralia (singular: centrale), and the first to fifth distal carpals. Primitively, each of the distal bones appears to have articulated with a single metacarpal. However, the vast majority of later vertebrates, including modern amphibians, have undergone varying degrees of loss and fusion of these primitive bones, resulting in a smaller number of carpals. Almost all mammals and reptiles, for example, have lost the fifth distal carpal, and have only a single centrale - and even this is missing in humans. The pisiform bone is somewhat unusual, in that it first appears in primitive reptiles, and is never found in amphibians. Because many tetrapods have less than five digits on the forelimb, even greater degrees of fusion are common, and a huge array of different possible combinations are found. The wing of a modern bird, for example, has only two remaining carpals; the radiale (the scaphoid of mammals) and a bone formed from the fusion of four of the distal carpals. In some macropods, the scaphoid and lunar bones are fused into the scaphollunar bone" ; obo:UBPROP_0000012 "we assume MA:carpus belongs here, as there is a distinct class MA:wrist, with the carpal bone being part of the former. XAO:carpus is part of the forelimb skeleton. FMA set-of class lacks definition but we assume this to be equivalent." ; oboInOwl:hasDbXref "AAO:0000201", "FMA:71335", "MA:0000040", "VHOG:0001161", "VSAO:0005023", "Wikipedia:Carpus", "XAO:0003207", "http://palaeos.com/vertebrates/glossary/images/382x366xUnciform1.jpg.pagespeed.ic.NirdxtwNVu.jpg" ; oboInOwl:hasExactSynonym "carpal bones", "carpal bones set", "fore mesopodial skeleton", "fore mesopodium skeleton", "ossa carpi", "skeletal parts of fore mesopodium", "skeleton of carpus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpus", "fore mesopodium", "ossa carpi", "set of carpal bones" ; oboInOwl:id "UBERON:0009880" ; a owl:Class ; rdfs:label "carpal skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0010544 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0010703 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 _:genid147379 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg"^^xsd:anyURI . obo:UBERON_0009881 oboInOwl:hasDbXref "EFO:0003704", "TAO:0005041", "ZFA:0005041" ; oboInOwl:hasExactSynonym "ALPM" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009881" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "anterior lateral plate mesoderm" ; rdfs:subClassOf obo:UBERON_0000479, _:genid149237 . obo:UBERON_0009882 obo:IAO_0000115 "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP]." ; oboInOwl:hasDbXref "FMA:15713", "NCIT:C32067", "SCTID:245444007", "UMLS:C0227428", "Wikipedia:Anal_columns" ; oboInOwl:hasExactSynonym "column of Morgagni" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "columnae anales" ; oboInOwl:id "UBERON:0009882" ; a owl:Class ; rdfs:label "anal column" ; rdfs:subClassOf obo:UBERON_0034944, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001910 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png"^^xsd:anyURI . obo:UBERON_0009883 obo:IAO_0000115 "A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla." ; obo:UBPROP_0000012 "FMA says parenchyma, MP says cortex" ; obo:UBPROP_0000013 "Their name is potentially misleading -- the 'medullary' refers to their destination, not their location. They are located only in the renal cortex, and not in the renal medulla" ; oboInOwl:hasDbXref "BTO:0001155", "EMAPA:37906", "FMA:74299", "Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy)" ; oboInOwl:hasExactSynonym "Ferrein's pyramid", "kidney medullary ray", "renal medullary ray" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009883" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "medullary ray" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001231 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001225 ], _:genid149247 . obo:UBERON_0009885 obo:IAO_0000115 "An artery that supplies a renal lobe." ; obo:UBPROP_0000012 "FMA only has the set term" ; oboInOwl:hasDbXref "EMAPA:37091", "FMA:71637", "SCTID:62802007", "Wikipedia:Interlobar_arteries" ; oboInOwl:hasExactSynonym "arteriae interlobares renis", "interlobar artery of kidney", "kidney interlobar artery", "renal interlobar artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arteriae interlobares renis", "interlobar arteries of kidney", "set of interlobar arteries of kidney" ; oboInOwl:id "UBERON:0009885" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "interlobar artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0009913 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png"^^xsd:anyURI . obo:UBERON_0009887 obo:IAO_0000115 "The interlobar veins are veins of the renal circulation which drain the renal lobes." ; obo:UBPROP_0000012 "FMA only has the set term" ; oboInOwl:hasDbXref "FMA:71631", "Wikipedia:Interlobar_veins" ; oboInOwl:hasExactSynonym "interlobar vein of kidney", "venae interlobares renis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interlobar veins of kidney", "set of interlobar veins of kidney", "venae interlobares renis" ; oboInOwl:id "UBERON:0009887" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "interlobar vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001140 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0009913 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png"^^xsd:anyURI . obo:UBERON_0009889 obo:IAO_0000115 "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." ; obo:UBPROP_0000001 "extra-cardiac population of mesodermal progenitors that gives rise to the right ventricle and outflow tract[PMID:17276708]." ; obo:UBPROP_0000008 "In general, the two studies in chick concluded that the contribution of the SHF was to the outflow tract, whereas the mouse work suggested that the second lineage contributed more broadly to the heart, including the outflow tract and much or all of the right ventricle [11-14]. These different conclusions may represent differences in the experimental approaches used or may represent bona fide differences in the contribution of the second lineage to the hearts of birds compared to mammals [11]. Alternatively, the secondary/anterior heart fields described in the chick may represent a subset of a broader field that makes a more substantial contribution to the heart, as the mouse studies suggested" ; obo:UBPROP_0000011 "in mouse has left ventricular identity[PMID:22855565]" ; oboInOwl:hasDbXref "XAO:0004186" ; oboInOwl:hasExactSynonym "anterior heart field", "anterior/second heart field", "second heart field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "SHF" ; oboInOwl:id "UBERON:0009889" ; a owl:Class ; rdfs:label "secondary heart field" ; rdfs:subClassOf obo:UBERON_0007688, _:genid149282, _:genid149284, _:genid149286 . obo:UBERON_0009891 obo:IAO_0000115 "Mesenchyme that is part of a developing face." ; oboInOwl:hasDbXref "EMAPA:35337", "FMA:302884" ; oboInOwl:hasExactSynonym "face mesenchyme", "mesenchyme of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009891" ; a owl:Class ; rdfs:label "facial mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] . obo:UBERON_0009911 obo:IAO_0000116 "todo - provide definition. Clearly distinguish between lobules, lobes and acinar parts of glands (see for example lobule of mammary gland)" ; oboInOwl:hasDbXref "FMA:45737", "NCIT:C12990", "UMLS:C0921005" ; oboInOwl:hasExactSynonym "lobulus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009911" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "lobule" ; rdfs:subClassOf obo:UBERON_0000063 . obo:UBERON_0009912 obo:IAO_0000115 "A portion of an organ, such as the liver, lung, breast, or brain." ; oboInOwl:hasDbXref "FMA:45728", "NCIT:C13393", "UMLS:C0796494" ; oboInOwl:hasExactSynonym "lobus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009912" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "anatomical lobe" ; rdfs:subClassOf obo:UBERON_0000063 . obo:UBERON_0009913 obo:IAO_0000115 "The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]." ; obo:IAO_0000116 "todo - add has_part relationships." ; obo:UBPROP_0000008 "human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys" ; oboInOwl:hasDbXref "FMA:17881", "NCIT:C32894", "UMLS:C0736382", "Wikipedia:Renal_lobe" ; oboInOwl:hasExactSynonym "kidney lobe", "lobi renalis", "lobus renalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobi renales" ; oboInOwl:id "UBERON:0009913" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renal lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png"^^xsd:anyURI . obo:UBERON_0009914 obo:IAO_0000115 "The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys." ; oboInOwl:hasDbXref "FMA:17670", "SCTID:361330004", "Wikipedia:Cortical_lobule" ; oboInOwl:hasExactSynonym "kidney lobule", "lobulus renalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cortical lobule", "cortical lobule of kidney", "lobuli corticales renis", "lobulus corticalis renalis", "renal cortical lobule", "renculus", "reniculus", "renunculus" ; oboInOwl:id "UBERON:0009914" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Alternate definition: One of the subdivisions of the kidney, consisting of a medullary ray and that portion of the convoluted port (renal corpuscles and convoluted tubules) associated with its collecting duct. -http://www.mondofacto.com/facts/dictionary?lobulus+corticalis+renalis" ; rdfs:label "renal lobule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001285 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0009883 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid149322 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0009916 obo:IAO_0000115 "An anatomical wall that is part of a ureter." ; oboInOwl:hasDbXref "FMA:15888", "SCTID:279397004" ; oboInOwl:hasExactSynonym "ureteral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009916" ; a owl:Class ; rdfs:label "wall of ureter" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005742 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006660 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0009917 obo:IAO_0000115 "The region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary." ; oboInOwl:hasDbXref "EMAPA:37886" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009917" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney corticomedullary boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid149351 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000362 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001225 ] ) ] . obo:UBERON_0009919 obo:IAO_0000115 "The smooth muscle tissue surrounding the epithelium of the ureter." ; oboInOwl:hasDbXref "EMAPA:28811" ; oboInOwl:hasExactSynonym "ureteral smooth muscle", "ureteral smooth muscle layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009919" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "ureter smooth muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006855 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000056 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0009920 oboInOwl:hasDbXref "EHDAA2:0001315", "EHDAA:1122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009920" ; a owl:Class ; rdfs:label "optic neural crest" ; rdfs:subClassOf obo:UBERON_0007530, _:genid149366 . obo:UBERON_0009953 obo:IAO_0000115 "A multicellular organism that existence_starts_with a post-embryonic stage." ; oboInOwl:hasDbXref "MA:0002405" ; oboInOwl:hasExactSynonym "postnatal organism" ; oboInOwl:hasNarrowSynonym "TS28 mouse", "post-hatching organism", "post-natal organism", "postnatal mouse" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009953" ; a owl:Class ; rdfs:label "post-embryonic organism" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/667"^^xsd:anyURI ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000092 ] ) ] . obo:UBERON_0009955 obo:IAO_0000115 "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." ; obo:IAO_0000232 "Includes: trigeminal, otic, lateral line and epibranchial placodes." ; obo:UBPROP_0000008 "While some sensory placodes (otic and olfactory) may have homologues in basal chordates (Wada et al., 1998), the so-called neurogenenic placodes (trigeminal, otic, lateral line and epibranchial placodes) appear to have emerged at a later time (Shimeld and Holland, 2000)" ; oboInOwl:hasDbXref "EFO:0003460", "TAO:0001309", "Wikipedia:Neurogenic_placodes", "XAO:0004620", "ZFA:0001309" ; oboInOwl:hasExactSynonym "neurogenic placodes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "placodae neurogenicae" ; oboInOwl:id "UBERON:0009955" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "neurogenic placode" ; rdfs:subClassOf obo:UBERON_0002546, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_2007013 ] ; owl:disjointWith obo:UBERON_0011814 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:CL_0000540 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0001714 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002385 ; owl:someValuesFrom obo:UBERON_0001785 ] ) ] . obo:UBERON_0009958 obo:IAO_0000115 "An anatomical space that is enclosed by a urinary bladder." ; oboInOwl:hasDbXref "EHDAA2:0004058", "FMA:15924", "SCTID:279405003", "galen:UrinaryBladderCavity" ; oboInOwl:hasExactSynonym "bladder cavity", "cavity of urinary bladder", "lumen of urinary bladder", "urinary bladder lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009958" ; a owl:Class ; rdfs:label "bladder lumen" ; rdfs:subClassOf _:genid149396, _:genid149398 ; owl:equivalentClass _:genid149391 . obo:UBERON_0009970 obo:IAO_0000115 "An epithelium that is part of a pancreatic duct." ; obo:IAO_0000116 "in EHDAA2, the embryonic pancreatic ducts (dorsal, ventral) are classified as eithelial sacs, which would render them subclasses of this" ; oboInOwl:hasDbXref "EFO:0002556", "FMA:67681" ; oboInOwl:hasExactSynonym "pancreatic duct epithelium", "pancreatic ductal epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009970" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "epithelium of pancreatic duct" ; rdfs:subClassOf _:genid149409 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007329 ] ) ] . obo:UBERON_0009972 obo:IAO_0000115 "The junction between the ureter and the renal pelvis of the kidney." ; oboInOwl:hasDbXref "EMAPA:37782", "FMA:15898", "MA:0003021", "NCIT:C106203", "SCTID:264130006" ; oboInOwl:hasExactSynonym "pelviureteric junction", "pelvoureteric junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009972" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ureteropelvic junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001008 ], _:genid149420 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001224 ] ) ] . obo:UBERON_0009973 obo:IAO_0000115 "The valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney." ; oboInOwl:hasDbXref "EMAPA:37783", "FMA:15899", "MA:0003020", "NCIT:C106202", "SCTID:261187001" ; oboInOwl:hasExactSynonym "vesico-ureteral junction", "vesico-ureteric junction", "vesicoureteric junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009973" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ureterovesical junction" ; rdfs:subClassOf obo:UBERON_0003978, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001008 ], _:genid149432 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000056 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0009979 obo:IAO_0000115 "An articular prominence of a bone, typically present in pairs, resembling a pair of knuckles. Examples: Condyle of humerus, condyle of femur." ; obo:UBPROP_0000001 "Protuberance on a bone that participates in a joint with another bone.[TAO]", "the round prominence at the end of a bone, most often part of a joint - an articulation with another bone[WP][Wikipedia:Condyle_(anatomy)]." ; obo:UBPROP_0000007 "condylar", "condyloid" ; oboInOwl:hasDbXref "FMA:75434", "NCIT:C83002", "SCTID:91737009", "TAO:0002259", "UMLS:C0524414", "Wikipedia:Condyle_(anatomy)", "galen:Condyle" ; oboInOwl:hasExactSynonym "condylus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009979" ; a owl:Class ; rdfs:label "condyle" ; rdfs:subClassOf obo:UBERON_0005913 . obo:UBERON_0009980 obo:IAO_0000115 "A condyle that is part of a distal epiphysis of femur." ; obo:UBPROP_0000001 "Convex articular facet of the distal head of the femur that articulates with the proximal head of the fibula.[AAO]" ; oboInOwl:hasDbXref "AAO:0000900", "FMA:32855", "NCIT:C114186", "SCTID:304912006", "galen:FemoralCondyle" ; oboInOwl:hasExactSynonym "condylus femoralis", "condylus femoris", "femoral condyle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibular condyle" ; oboInOwl:id "UBERON:0009980" ; a owl:Class ; rdfs:label "condyle of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004406 ] ) ] . obo:UBERON_0009984 obo:IAO_0000115 "The medial condyle is one of the two projections on the lower extremity of femur. The medial condyle is larger than the lateral (outer) condyle due to more weight bearing caused by the center of gravity being medial to the knee. On the posterior surface of the condyle the linea aspera (a ridge running down the posterior shaft of the femur) turns into the medial supracondylar ridge. The outermost protrusion on the medial surface of the medial condyle is referred to as the 'medial epicondyle' and can be palpated by running fingers medially from the patella with the knee in flexion." ; oboInOwl:hasDbXref "FMA:32858", "SCTID:182056007", "Wikipedia:Medial_condyle_of_femur" ; oboInOwl:hasExactSynonym "condylus medialis femoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "c. medialis femoris", "medial condyle of the femur", "medial femoral condyle" ; oboInOwl:id "UBERON:0009984" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medial condyle of femur" ; rdfs:subClassOf obo:UBERON_0009980, _:genid149451 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray246.png"^^xsd:anyURI . obo:UBERON_0009988 obo:IAO_0000115 "The distal end of the humerus, including the trochlea, capitulum and the olecranon, coronoid and radial fossae." ; obo:RO_0002171 obo:UBERON_0016497 ; obo:UBPROP_0000008 "As in the N.A., the Condylus humeri is the whole distal end of the bone except the epicondyles. The Capitulum humeri is present in Carnivora, more distinctly in the cat than in the dog. The Fossa coronoidea, present in the cat is medial to the Fossa radialis and accommodates the Processus coronoideus medialis ulnae when the elbow is flexed. A Foramen supratrochleare occurs in carnivora and occasionally in pig.[NOMINA ANATOMICA VETERINARIA (2005)]" ; oboInOwl:hasDbXref "FMA:23377", "SCTID:361778001" ; oboInOwl:hasExactSynonym "condylus humeri", "humeral condyle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009988" ; a owl:Class ; rdfs:label "condyle of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004404 ] ) ] . obo:UBERON_0009989 obo:IAO_0000115 "One of the lateral or medial condyles of the tibia." ; obo:UBPROP_0000001 "Convex articular facet of the distal head of the femur that articulates with the proximal head of the tibia.[AAO]" ; oboInOwl:hasDbXref "AAO:0000899", "SCTID:182062002", "Wikipedia:Tibial_condyle" ; oboInOwl:hasExactSynonym "tibial condyle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0009989" ; a owl:Class ; rdfs:label "condyle of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008772 ] ) ] . obo:UBERON_0010000 obo:IAO_0000115 "An anatomical structure that has more than one cell as a part." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "CARO:0010000", "FBbt:00100313" ; oboInOwl:hasExactSynonym "multicellular structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010000" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "multicellular anatomical structure" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000000 ] ; owl:equivalentClass _:genid147617 . obo:UBERON_0010005 obo:IAO_0000115 "The vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation." ; oboInOwl:hasExactSynonym "villous of placental labyrinth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "placental labyrinth villi" ; oboInOwl:id "UBERON:0010005" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "placental labyrinth villous" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003946 ], _:genid149479 . obo:UBERON_0010009 obo:IAO_0000115 "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." ; obo:IAO_0000116 "May be obsoleted." ; oboInOwl:hasDbXref "FMA:256381", "NLXANAT:20090509" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of nuclei of neuraxis" ; oboInOwl:id "UBERON:0010009" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "aggregate regional part of brain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0002616 ] ) ] . obo:UBERON_0010011 obo:IAO_0000115 "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." ; obo:IAO_0000116 "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the collection of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." ; obo:UBPROP_0000003 "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" ; oboInOwl:hasDbXref "BAMS:BG", "BIRNLEX:826", "BM:Tel-BG", "DHBA:10331", "EMAPA:32673", "FMA:84013", "GAID:617", "HBA:4275", "HBA:4276", "MA:0000184", "MBA:623", "MESH:D001479", "NCIT:C12447", "PBA:128012596", "PBA:4001", "UMLS:C0004781", "VHOG:0001696", "Wikipedia:Basal_ganglia", "neuronames:2677" ; oboInOwl:hasExactSynonym "basal ganglia", "basal ganglia set", "basal nuclei (basal ganglia)", "set of basal ganglia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal nuclei", "cerebral nuclei", "set of basal nuclei", "subcortical nuclei" ; oboInOwl:id "UBERON:0010011" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "collection of basal ganglia" ; rdfs:subClassOf obo:UBERON_0010009, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001891 ], _:genid149493, _:genid149496 . obo:UBERON_0010020 obo:IAO_0000115 "The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity." ; obo:UBPROP_0000003 "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0004115", "EHDAA:6772", "EMAPA:17002", "MA:0001218", "NCIT:C34318", "SCTID:361516008", "UMLS:C1284046", "VHOG:0001297" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tubotympanic recess" ; oboInOwl:id "UBERON:0010020" ; a owl:Class ; rdfs:label "tubotympanic recess epithelium" ; rdfs:subClassOf obo:UBERON_0005423, obo:UBERON_0007499, _:genid149509, _:genid149511 . obo:UBERON_0010031 obo:IAO_0000115 "Mesenchyme that is part of a pharyngeal arch 6." ; oboInOwl:hasDbXref "EHDAA2:0004076", "EMAPA:32765", "FMA:318209" ; oboInOwl:hasExactSynonym "6th pharyngeal arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "6th branchial arch mesenchyme", "pharyngeal arch 6 mesenchyme" ; oboInOwl:id "UBERON:0010031" ; a owl:Class ; rdfs:label "6th arch mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003117 ] ) ] . obo:UBERON_0010032 obo:IAO_0000115 "The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch." ; obo:UBPROP_0000011 "The lateral lingual swellings grow and fuse with eachother, encompassing the tuberculum impar to provide the ectodermally derived mucosa of the anterior 2/3 of the tongue" ; obo:UBPROP_0000012 "check NCIT" ; oboInOwl:hasDbXref "EMAPA:37437", "FMA:229084", "NCIT:C32130", "UMLS:C0226946", "Wikipedia:Anterior_tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior 2/3 of the tongue", "anterior 2/3 of tongue", "anterior two thirds of the tongue", "apex linguae", "apex of the tongue", "buccal part of the tongue", "front of the tongue", "oral part of the tongue", "pars anterior dorsi linguae" ; oboInOwl:id "UBERON:0010032" ; a owl:Class ; rdfs:label "anterior part of tongue" ; owl:disjointWith obo:UBERON_0010033 ; owl:equivalentClass _:genid149522 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg"^^xsd:anyURI . obo:UBERON_0010033 obo:IAO_0000115 "The Posterior tongue, or pharyngeal part, is the part of the tongue behind the terminal sulcus. At its root, it is directed backward, and connected with the hyoid bone by the Hyoglossi and Genioglossi muscles and the hyoglossal membrane; with the epiglottis by three folds (glossoepiglottic) of mucous membrane; with the soft palate by the glossopalatine arches; and with the pharynx by the Constrictores pharyngis superiores and the mucous membrane. It is derived primarily from the third pharyngeal arch. (The second arch has a substantial contribution during fetal development, but this later atrophies. The fourth arch may also contribute, depending upon how the boundaries of the tongue are defined.)." ; oboInOwl:hasDbXref "EMAPA:37438", "FMA:54645", "MA:0003031", "NCIT:C12228", "SCTID:362094001", "UMLS:C0226958", "Wikipedia:Posterior_tongue" ; oboInOwl:hasExactSynonym "base of tongue", "pars posterior (dorsum linguae)", "pars posterior dorsi linguae", "pars posterior linguae", "pars postsulcalis (dorsum linguae)", "pharyngeal part of tongue", "pharyngeal portion of dorsum of tongue", "posterior part of dorsum of tongue", "postsulcal part of dorsum of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "base of the tongue", "pharyngeal part of the tongue", "posterior 1/3 of the tongue", "posterior third of tongue", "radix linguae" ; oboInOwl:id "UBERON:0010033" ; a owl:Class ; rdfs:label "posterior part of tongue" ; rdfs:subClassOf obo:UBERON_0000064, _:genid149543, _:genid149545 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg"^^xsd:anyURI . obo:UBERON_0010039 obo:IAO_0000115 "An organ of the digestive tract that is capable of retaining and storing food." ; obo:IAO_0000232 "This is a very broad functionally defined grouping class that collects disparate structures from insects to vertebrates" ; oboInOwl:hasDbXref "BSA:0000123", "TADS:0000172", "TGMA:0001041" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010039" ; oboInOwl:inSubset core:functional_classification, core:grouping_class ; a owl:Class ; rdfs:label "food storage organ" ; rdfs:subClassOf obo:UBERON_0000062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] . obo:UBERON_0010042 obo:IAO_0000115 "Mesenchyme that is part of a pharyngeal arch 1." ; oboInOwl:hasDbXref "EMAPA:16128" ; oboInOwl:hasExactSynonym "mesenchyme of 1st arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010042" ; a owl:Class ; rdfs:label "1st arch mesenchyme" ; owl:equivalentClass _:genid147704 . obo:UBERON_0010045 obo:IAO_0000115 "Mesenchyme that is part of a 1st arch maxillary component." ; oboInOwl:hasDbXref "EHDAA2:0000041", "EMAPA:16391" ; oboInOwl:hasExactSynonym "mesenchyme of maxillary component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillary component mesenchyme", "maxillary mesenchyme" ; oboInOwl:id "UBERON:0010045" ; a owl:Class ; rdfs:label "1st arch maxillary mesenchyme" ; owl:equivalentClass _:genid147710 . obo:UBERON_0010046 obo:IAO_0000115 "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." ; oboInOwl:hasDbXref "EHDAA2:0001459", "EMAPA:16550", "XAO:0004524" ; oboInOwl:hasExactSynonym "associated mesenchyme of pharyngeal region", "entire branchial arch associated mesenchyme", "pharyngeal arch associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010046" ; a owl:Class ; rdfs:label "entire pharyngeal arch associated mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid149580, _:genid149582 . obo:UBERON_0010047 obo:IAO_0000115 "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." ; obo:UBPROP_0000012 "Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa" ; oboInOwl:hasAlternativeId "UBERON:0003293" ; oboInOwl:hasDbXref "EHDAA2:0001327", "EHDAA:2181", "EMAPA:16572", "EMAPA:16723", "VHOG:0000652" ; oboInOwl:hasNarrowSynonym "buccal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gland of oral opening", "gland of oral region", "mouth gland", "oral cavity gland", "oral region gland" ; oboInOwl:id "UBERON:0010047" ; a owl:Class ; rdfs:label "oral gland" ; rdfs:subClassOf obo:UBERON_0002365 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ) ] . obo:UBERON_0010052 obo:IAO_0000115 "A mucosa that is part of a dorsum of tongue." ; obo:IAO_0000116 "check surface terms" ; obo:UBPROP_0000011 "develops fungiform papillae by WNT induction at 11 weeks pc in human. Filiform papillae develop later. ISBN:1607950324" ; oboInOwl:hasDbXref "FMA:74871", "SCTID:245835003" ; oboInOwl:hasExactSynonym "mucosa of dorsal surface of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010052" ; a owl:Class ; rdfs:label "mucosa of dorsum of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 _:genid147731 ) ] . obo:UBERON_0010054 obo:IAO_0000115 "A malleus endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EMAPA:18229" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010054" ; a owl:Class ; rdfs:label "malleus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006262 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015018 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010055 obo:IAO_0000115 "A stapes endochondral element that is composed primarily of cartilage tissue." ; obo:IAO_0000116 "TODO - check relationship to Recihert's" ; obo:UBPROP_0000008 "The stapes is homologous to the hyomandibula. In this ontology, we use the class 'hyomandibular cartilage' generally to include the future stapes, the future hyomandibular bone of teleosts and the unossified cartilage in sharks." ; oboInOwl:hasDbXref "EMAPA:18230" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010055" ; a owl:Class ; rdfs:label "stapes cartilage element" ; rdfs:subClassOf obo:UBERON_0011607, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001686 ], _:genid147745 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015016 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010056 obo:IAO_0000115 "A compound organ that has the potential to develop into a tongue." ; oboInOwl:hasDbXref "EHDAA2:0000696", "EHDAA:2951" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010056" ; a owl:Class ; rdfs:label "future tongue" ; rdfs:subClassOf obo:UBERON_0003103, obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003103 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0010059 oboInOwl:hasDbXref "EHDAA2:0004610" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010059" ; a owl:Class ; rdfs:label "hypoglossal cord" ; rdfs:subClassOf obo:UBERON_0002036, _:genid149621 . obo:UBERON_0010060 obo:IAO_0000115 "On the lateral wall of the nasal part of the pharynx is the pharyngeal opening of auditory tube (pharyngeal ostium), somewhat triangular in shape, and bounded behind by a firm prominence, the torus or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane." ; oboInOwl:hasDbXref "FMA:54979", "SCTID:368945008", "Wikipedia:Pharyngeal_opening_of_auditory_tube" ; oboInOwl:hasExactSynonym "ostium pharyngeum tubae auditivae", "ostium pharyngeum tubae auditoriae", "pharyngeal opening of auditory tube", "pharyngeal opening of eustachian tube", "pharyngeal orifice of auditory tube", "pharyngeal orifice of eustachian tube", "pharyngeal orifice of pharyngotympanic tube", "pharyngeal ostium of auditory tube", "pharyngeal ostium of eustachian tube", "pharyngeal ostium of pharyngotympanic tube", "pharyngeal tubal ostium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ostium pharyngeum tubae auditivae", "pharyngeal ostium" ; oboInOwl:id "UBERON:0010060" ; a owl:Class ; rdfs:label "pharyngeal opening of pharyngotympanic tube" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0010061 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray1029.png"^^xsd:anyURI . obo:UBERON_0010061 oboInOwl:hasDbXref "FMA:55094" ; oboInOwl:hasExactSynonym "nasopharyngeal luman", "nasopharynx cavity", "nasopharynx lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010061" ; a owl:Class ; rdfs:label "lumen of nasopharynx" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001731 ] . obo:UBERON_0010062 oboInOwl:hasDbXref "EHDAA2:0004117", "EMAPA:32801", "FMA:285217", "MA:0003142" ; oboInOwl:hasExactSynonym "auditory tube epithelium", "eustachian tube epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010062" ; a owl:Class ; rdfs:label "pharyngotympanic tube epithelium" ; rdfs:subClassOf obo:UBERON_0003914, _:genid149643, _:genid149645 . obo:UBERON_0010063 oboInOwl:hasDbXref "EHDAA2:0004116" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010063" ; a owl:Class ; rdfs:label "tympanic cavity epithelium" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0004114 ], _:genid149650, _:genid149653 . obo:UBERON_0010064 obo:IAO_0000115 "An anatomical space with at least one opening to another space or the exterior." ; oboInOwl:hasDbXref "AEO:0000221", "EHDAA2:0004616" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010064" ; a owl:Class ; rdfs:label "open anatomical space" ; rdfs:subClassOf _:genid149659 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000610 ] ) ] . obo:UBERON_0010065 oboInOwl:hasDbXref "EHDAA2:0004114" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010065" ; a owl:Class ; rdfs:label "auditory meatus epithelium" ; rdfs:subClassOf obo:UBERON_0003914, _:genid149663, _:genid149665 . obo:UBERON_0010069 obo:IAO_0000115 "A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane." ; oboInOwl:hasDbXref "FMA:56819", "SCTID:39725007" ; oboInOwl:hasExactSynonym "cuticular layer of tympanic membrane", "cuticular stratum of tympanic membrane", "outer cuticular layer of tympanic membrane", "outer layer of tympanic membrane", "tympanic membrane external acoustic meatus epithelial component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010069" ; a owl:Class ; rdfs:label "outer epithelial layer of tympanic membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009647 _:genid147796 ) ] . obo:UBERON_0010070 obo:IAO_0000115 "The intermediate fibrous layer of the tympanic membrane." ; obo:UBPROP_0000012 "check MA" ; oboInOwl:hasDbXref "EMAPA:19063", "FMA:56830", "MA:0001223", "SCTID:44692008" ; oboInOwl:hasExactSynonym "connective tissue layer of tympanic membrane", "fibrous layer of tympanic membrane", "fibrous stratum of tympanic membrane", "intermediate fibrous layer of tympanic membrane", "tympanic endothelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010070" ; a owl:Class ; rdfs:label "intermediate layer of tympanic membrane" ; rdfs:subClassOf obo:UBERON_0010071 . obo:UBERON_0010071 obo:UBPROP_0000008 "In mammals, this class groups together the two epithelial layers plus the intermediate fibrous layer" ; oboInOwl:hasDbXref "FMA:56732" ; oboInOwl:hasExactSynonym "tympanic membrane layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010071" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "layer of tympanic membrane" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002364 ] . obo:UBERON_0010074 obo:IAO_0000115 "Organ system subdivision that consists primarily of chromaffin cells and their supporting structures." ; obo:UBPROP_0000008 "in adult cylostomes and teleosts, the interrenal bodies are separate from chromaffin bodies" ; oboInOwl:hasDbXref "FMA:79645", "MESH:D002838" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "argentaffin system", "chromaffin tissue" ; oboInOwl:id "UBERON:0010074" ; a owl:Class ; rdfs:label "chromaffin system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000166 ], _:genid149686, _:genid149688 . obo:UBERON_0010075 obo:IAO_0000115 "One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia." ; oboInOwl:hasDbXref "XAO:0004192" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010075" ; a owl:Class ; rdfs:label "sacral neural crest" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002342 ] . obo:UBERON_0010076 obo:IAO_0000115 "Tissue cavity consisting of intercommunicating trabecular spaces in the cancellous bone." ; oboInOwl:hasDbXref "FMA:259332" ; oboInOwl:hasExactSynonym "trabecular network of bone tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trabecular space network" ; oboInOwl:id "UBERON:0010076" ; a owl:Class ; rdfs:label "network of trabecular spaces in bone tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008867 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0008867 ] ) ] . obo:UBERON_0010077 obo:IAO_0000115 "An epithelium consisting of cuboidal epithelial cells." ; obo:IAO_0000116 "TODO - coordinate with CL, add cuboidal cell" ; obo:UBPROP_0000012 "in NCIT this is glandular" ; oboInOwl:hasDbXref "NCIT:C32415", "UMLS:C0682577", "Wikipedia:Cuboidal_epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010077" ; a owl:Class ; rdfs:label "cuboidal epithelium" ; rdfs:subClassOf obo:UBERON_0000483 . obo:UBERON_0010081 obo:IAO_0000115 "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." ; oboInOwl:hasDbXref "EHDAA2:0000595" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010081" ; a owl:Class ; rdfs:label "future common hepatic duct" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005604 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003703 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001175 ] ) ] . obo:UBERON_0010083 obo:IAO_0000115 "Mesenchyme that has the potential to develop into a dermis." ; obo:IAO_0000116 "check development" ; oboInOwl:hasDbXref "EHDAA2:0000598" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010083" ; a owl:Class ; rdfs:label "future dermis" ; rdfs:subClassOf _:genid149716, _:genid149718, _:genid149720 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002067 ] ) ] . obo:UBERON_0010084 obo:IAO_0000115 "A structure that will develop into a diaphragm." ; oboInOwl:hasDbXref "EHDAA2:0000599" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010084" ; a owl:Class ; rdfs:label "future diaphragm" ; rdfs:subClassOf _:genid149727, _:genid149729, _:genid149731 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] . obo:UBERON_0010090 obo:IAO_0000115 "A developing anatomical structure that has the potential to develop into a falx cerebri." ; oboInOwl:hasDbXref "EHDAA2:0000608" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010090" ; a owl:Class ; rdfs:label "future falx cerebri" ; rdfs:subClassOf obo:UBERON_0007524 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0006059 ] ) ] . obo:UBERON_0010091 obo:IAO_0000115 "A multi-tissue structure that has the potential to develop into a meninx of hindbrain." ; oboInOwl:hasDbXref "EHDAA2:0000610" ; oboInOwl:hasExactSynonym "future hindbrain meninges" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010091" ; a owl:Class ; rdfs:label "future hindbrain meninx" ; rdfs:subClassOf obo:UBERON_0007524, _:genid147862 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 _:genid147860 ) ] . obo:UBERON_0010092 obo:IAO_0000115 "A developing anatomical structure that has the potential to develop into a metencephalon." ; oboInOwl:hasDbXref "EHDAA2:0000623" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010092" ; a owl:Class ; rdfs:label "future metencephalon" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001895 ] ) ] . obo:UBERON_0010096 obo:IAO_0000115 "A developing anatomical structure that has the potential to develop into a myelencephalon." ; oboInOwl:hasDbXref "EHDAA2:0000640" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010096" ; a owl:Class ; rdfs:label "future myelencephalon" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0005290 ] ) ] . obo:UBERON_0010123 obo:IAO_0000115 "A gray matter that has the potential to develop into a facial nucleus." ; oboInOwl:hasDbXref "EHDAA2:0004639" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010123" ; a owl:Class ; rdfs:label "future facial nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000127 ] ) ] . obo:UBERON_0010125 obo:IAO_0000115 "A gray matter that has the potential to develop into a superior salivatory nucleus." ; oboInOwl:hasDbXref "EHDAA2:0004644" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010125" ; a owl:Class ; rdfs:label "future superior salivatory nucleus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002149 ] ) ] . obo:UBERON_0010129 obo:IAO_0000115 "A femur endochondral element that is composed primarily of cartilage tissue." ; obo:IAO_0000116 "TODO - request EHDAA2" ; oboInOwl:hasDbXref "EMAPA:17742" ; oboInOwl:hasExactSynonym "femoral cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010129" ; a owl:Class ; rdfs:label "femur cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006234 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000981 ], _:genid149772 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015052 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010130 obo:IAO_0000115 "The distal elements of the developing limb of vertebrates that will give rise to the autopod (e.g. manus, pes, paw)." ; oboInOwl:hasExactSynonym "autopod plate", "limb plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010130" ; a owl:Class ; rdfs:label "embryonic autopod plate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004347 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002050 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002470 ] ) ] . obo:UBERON_0010131 obo:IAO_0000115 "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." ; oboInOwl:hasDbXref "EHDAA2:0004528", "FMA:83378" ; oboInOwl:hasExactSynonym "specialized conducting tissue of heart", "specialized muscle tissue of heart" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010131" ; a owl:Class ; rdfs:label "conducting tissue of heart" ; rdfs:subClassOf obo:UBERON_0001133 . obo:UBERON_0010133 obo:IAO_0000115 "Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli." ; oboInOwl:hasDbXref "MA:0000720" ; oboInOwl:hasExactSynonym "neuroendocrine system gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010133" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "neuroendocrine gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002368 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0010134 obo:IAO_0000115 "A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid." ; oboInOwl:hasDbXref "EMAPA:35759", "MA:0002943", "neuronames:2857" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010134" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "secretory circumventricular organ" ; rdfs:subClassOf obo:UBERON_0005408, obo:UBERON_0010133 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005408 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ] ) ] . obo:UBERON_0010135 obo:IAO_0000115 "A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid." ; oboInOwl:hasDbXref "EMAPA:37741", "MA:0002944", "neuronames:2856" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "humerosensory circumventricular organ", "humerosensory system", "humerosensory system organ", "sensitive circumventricular organs", "sensitive organs", "sensory CVOs", "sensory circumventricular organs" ; oboInOwl:id "UBERON:0010135" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "sensory circumventricular organ" ; owl:equivalentClass _:genid147918 . obo:UBERON_0010141 obo:IAO_0000115 "A sex cord that is part of a indifferent gonad." ; obo:IAO_0000232 "note that this represents the indifferent structure." ; oboInOwl:hasDbXref "EHDAA2:0004051" ; oboInOwl:hasExactSynonym "indifferent sex cord", "primitive sex cords" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010141" ; a owl:Class ; rdfs:label "primitive sex cord of indifferent gonad" ; rdfs:subClassOf _:genid149816 ; owl:equivalentClass _:genid149811 . obo:UBERON_0010143 obo:IAO_0000115 "A bodily secretion that is produced by a seminal vesicle." ; obo:UBPROP_0000008 "constitutes 60-70 % of the ejaculate in humans[MP]" ; obo:UBPROP_0000009 "important for semen coagulation, sperm motility, and stability of sperm chromatin and suppression of the immune activity in the female reproductive tract[MP]" ; obo:UBPROP_0000012 "in ncit, seminal fluid is a subtype of seminal vesicle secretion" ; oboInOwl:hasBroadSynonym "vesicular fluid" ; oboInOwl:hasDbXref "BTO:0002053", "FMA:62969", "MA:0002526", "NCIT:C33529", "NCIT:C52552", "UMLS:C0036614", "UMLS:C0227987" ; oboInOwl:hasExactSynonym "secretion of seminal vesicle", "seminal vesicle secretion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "seminal fluid" ; oboInOwl:id "UBERON:0010143" ; a owl:Class ; rdfs:label "seminal vesicle fluid" ; rdfs:subClassOf obo:UBERON_0006530 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000456 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ] . obo:UBERON_0010147 obo:IAO_0000115 "Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male." ; oboInOwl:hasDbXref "BTO:0004798" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male accessory gland", "male accessory reproductive gland" ; oboInOwl:id "UBERON:0010147" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "male accessory sex gland" ; rdfs:subClassOf obo:UBERON_0005399, _:genid147948 . obo:UBERON_0010152 obo:IAO_0000115 "A mucous secretion that is produced by glands in the epidermis." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epidermal mucus", "skin mucous" ; oboInOwl:id "UBERON:0010152" ; a owl:Class ; rdfs:label "skin mucus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0004790 ] ) ] . obo:UBERON_0010155 obo:IAO_0000115 "Unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP:Squamosal_suture]." ; oboInOwl:hasDbXref "FMA:52947", "SCTID:136753005" ; oboInOwl:hasExactSynonym "parieto-mastoid suture of skull", "parietomastoid suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010155" ; a owl:Class ; rdfs:label "parietomastoid suture" ; rdfs:subClassOf obo:UBERON_0003685, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000210 ], _:genid147959 . obo:UBERON_0010156 obo:IAO_0000115 "The Sphenofrontal suture is the cranial suture between the sphenoid bone and the frontal bone." ; oboInOwl:hasDbXref "FMA:52938", "SCTID:136349005", "Wikipedia:Sphenofrontal_suture" ; oboInOwl:hasExactSynonym "frontosphenoid suture", "sphenofrontal suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spheno-frontal suture", "sphenofrontal", "sutura sphenofrontalis" ; oboInOwl:id "UBERON:0010156" ; a owl:Class ; rdfs:label "sphenofrontal suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001677 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png"^^xsd:anyURI . obo:UBERON_0010157 obo:IAO_0000115 "The Sphenoparietal suture is the cranial suture between the sphenoid bone and the parietal bone." ; oboInOwl:hasDbXref "FMA:52945", "SCTID:136551005", "Wikipedia:Sphenoparietal_suture" ; oboInOwl:hasExactSynonym "spheno-parietal suture", "sphenoparietal suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sutura sphenoparietalis" ; oboInOwl:id "UBERON:0010157" ; a owl:Class ; rdfs:label "sphenoparietal suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001677 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png"^^xsd:anyURI . obo:UBERON_0010158 obo:IAO_0000115 "The Sphenozygomatic suture is the cranial suture between the sphenoid bone and the zygomatic bone." ; oboInOwl:hasDbXref "FMA:52956", "SCTID:368980007", "Wikipedia:Sphenozygomatic_suture" ; oboInOwl:hasExactSynonym "sphenozygomatica suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sutura sphenozygomatica" ; oboInOwl:id "UBERON:0010158" ; a owl:Class ; rdfs:label "sphenozygomatic suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001677 ] _:genid147987 ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png"^^xsd:anyURI . obo:UBERON_0010160 obo:IAO_0000115 "An anatomical cavity that surrounded_by a lymphatic vessel." ; oboInOwl:hasDbXref "FMA:59681" ; oboInOwl:hasExactSynonym "lumen of lymphatic duct", "lymphatic vessel lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010160" ; a owl:Class ; rdfs:label "lumen of lymphatic vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001473 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001473 ] ) ] . obo:UBERON_0010161 obo:IAO_0000115 "An anatomical cavity that surrounded_by a blood vessel." ; oboInOwl:hasDbXref "FMA:312610", "SCTID:91747007" ; oboInOwl:hasExactSynonym "blood vessel lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010161" ; a owl:Class ; rdfs:label "lumen of blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0010162 obo:IAO_0000115 "The distal end of the tail." ; oboInOwl:hasDbXref "EMAPA:37760", "MA:0002848", "XAO:0004057" ; oboInOwl:hasExactSynonym "tail tip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "end of tail" ; oboInOwl:id "UBERON:0010162" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "post-anal tail tip" ; rdfs:subClassOf _:genid149894 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011676 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001108 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0010163 obo:IAO_0000115 "The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges. Their main function is to protect the eye, but they are also important to human communication and facial expression. It is not uncommon for people to modify their eyebrows by means of hair addition or removal, make up, or piercings." ; obo:UBPROP_0000012 "in NCIT, this is an 'eye appendage'" ; oboInOwl:hasDbXref "FMA:54237", "MESH:D005138", "NCIT:C32575", "SCTID:265781000", "UMLS:C0015420", "Wikipedia:Eyebrow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "supercilium" ; oboInOwl:id "UBERON:0010163" ; oboInOwl:inSubset core:pheno_slim, core:phenotype_rcn ; a owl:Class ; rdfs:label "eyebrow" ; rdfs:subClassOf obo:UBERON_0010165, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/29/Eyes_chris.jpg"^^xsd:anyURI . obo:UBERON_0010164 obo:IAO_0000115 "An anatomical cluster that composed_primarily_of a strand of hair." ; oboInOwl:hasDbXref "FMA:70752" ; oboInOwl:hasExactSynonym "hairs", "hairs set", "pili", "set of hairs" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010164" ; a owl:Class ; rdfs:label "collection of hairs" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0010001 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034925 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0001037 ] ) ] . obo:UBERON_0010165 obo:IAO_0000115 "A collection of hairs that is part of a face." ; oboInOwl:hasDbXref "FMA:70741" ; oboInOwl:hasExactSynonym "facial hairs set", "set of facial hairs" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial hair" ; oboInOwl:id "UBERON:0010165" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "collection of hair on face" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0010171 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] . obo:UBERON_0010168 obo:IAO_0000115 "A collection of hair on face that is part of a eyelash." ; oboInOwl:hasDbXref "FMA:70742", "SCTID:367575006" ; oboInOwl:hasExactSynonym "cilia", "eyelashes", "eyelashes set", "set of eyelashes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010168" ; a owl:Class ; rdfs:label "collection of eyelashes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010165 [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0001702 ] ) ] . obo:UBERON_0010171 obo:IAO_0000115 "A strand of hair that is part of a face." ; oboInOwl:hasDbXref "FMA:54360", "SCTID:368910000" ; oboInOwl:hasExactSynonym "face hair", "face hair strand", "hair of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial hair" ; oboInOwl:id "UBERON:0010171" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "strand of hair of face" ; owl:equivalentClass _:genid148048 . obo:UBERON_0010172 obo:IAO_0000115 "The portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles." ; obo:UBPROP_0000001 "The dilated first part of the aorta containing the aortic semilunar valves and the aortic sinuses." ; oboInOwl:hasDbXref "BTO:0004695", "FMA:3740", "SCTID:362032000" ; oboInOwl:hasExactSynonym "aorta bulb", "aortic bulb", "aortic root", "bulb of ascending aorta", "bulbus aortae", "root of aorta", "supraaortic valve area" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010172" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bulb of aorta" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001496 ], _:genid149941 . obo:UBERON_0010183 obo:IAO_0000115 "A trabecula that is part of a liver." ; oboInOwl:hasExactSynonym "liver trabeculae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic trabecula" ; oboInOwl:id "UBERON:0010183" ; a owl:Class ; rdfs:label "liver trabecula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000440 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0010186 obo:IAO_0000115 "Any of the numerous small mucous-secreting glands located in the wall of the penile urethra." ; oboInOwl:hasDbXref "EMAPA:29645", "FMA:21443", "NCIT:C49311", "SCTID:303562001", "UMLS:C1314737", "Wikipedia:Urethral_gland" ; oboInOwl:hasExactSynonym "Littre's gland", "gland of Littre", "gland of male urethra", "male urethra gland", "urethral gland (male)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandulae urethrales urethrae masculinae" ; oboInOwl:id "UBERON:0010186" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "male urethral gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001338 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 ] ) ] . obo:UBERON_0010187 obo:IAO_0000115 "An urethral gland that is part of a female urethra." ; oboInOwl:hasDbXref "EMAPA:29653", "FMA:21444", "SCTID:279476001" ; oboInOwl:hasExactSynonym "female urethra gland", "gland of female urethra", "urethral gland (female)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010187" ; a owl:Class ; rdfs:label "female urethral gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001338 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:UBERON_0010188 obo:IAO_0000115 "A roughly circular bulge in a surface." ; obo:IAO_0000116 "requires review" ; oboInOwl:hasDbXref "AEO:0000205", "EHDAA2:0003250", "FMA:82506" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010188" ; a owl:Class ; rdfs:label "protuberance" ; rdfs:subClassOf obo:UBERON_0034944 . obo:UBERON_0010189 obo:UBPROP_0000012 "part_of in EHDAA2. Only child in MA." ; oboInOwl:hasDbXref "EHDAA2:0001762", "EMAPA:17010", "EMAPA:17328", "MA:0001872" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "right venous valve" ; oboInOwl:id "UBERON:0010189" ; a owl:Class ; rdfs:label "right atrium venous valve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006675 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ] ) ] . obo:UBERON_0010191 oboInOwl:hasDbXref "EHDAA2:0004512" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010191" ; a owl:Class ; rdfs:label "aortic system" ; rdfs:subClassOf obo:UBERON_0011216, _:genid149982 . obo:UBERON_0010192 obo:IAO_0000115 "One of the laterally paired arteries that supply the gonads." ; oboInOwl:hasDbXref "Wikipedia:Gonadal_artery" ; oboInOwl:hasExactSynonym "gonadal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010192" ; a owl:Class ; rdfs:label "genital artery" ; rdfs:subClassOf _:genid149988 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004573 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000991 ] ) ] . obo:UBERON_0010194 obo:IAO_0000115 "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver." ; obo:UBPROP_0000001 "Part of the circulatory system which includes the ventral abdominal vein, pelvic veins, and portal vein and collects blood from the pelvic region, liver, gall bladder and stomach.[AAO]" ; oboInOwl:hasDbXref "AAO:0010225" ; oboInOwl:hasExactSynonym "hepatic-portal system", "portal system of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010194" ; a owl:Class ; rdfs:label "hepatic portal system" ; rdfs:subClassOf obo:UBERON_0005806, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001555 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002107 ] . obo:UBERON_0010199 obo:IAO_0000115 "An anatomical boundary that corresponds to some physical discontinuity." ; oboInOwl:hasDbXref "CARO:0001004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010199" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:comment "One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102)" ; rdfs:label "bona-fide anatomical boundary" ; rdfs:subClassOf obo:UBERON_0000466 . obo:UBERON_0010204 obo:IAO_0000115 "A vasculature that is part of a post-anal tail." ; obo:UBPROP_0000012 "isa blood vessel in XAO" ; oboInOwl:hasDbXref "TAO:0005037", "XAO:0004151", "ZFA:0005037" ; oboInOwl:hasExactSynonym "post-vent vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tail vasculature" ; oboInOwl:id "UBERON:0010204" ; a owl:Class ; rdfs:label "tail vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0010210 obo:IAO_0000115 "A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network." ; oboInOwl:hasDbXref "BTO:0000102", "Wikipedia:Thrombus", "galen:BloodClot" ; oboInOwl:hasExactSynonym "coagulated blood", "fibrin clot", "hemostatic plug", "thrombus" ; oboInOwl:hasNarrowSynonym "clot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010210" ; a owl:Class ; rdfs:label "blood clot" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000232 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000233 ], _:genid148124, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005577 ], _:genid150014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0007596 ] ) ] . obo:UBERON_0010212 obo:IAO_0000115 "Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring." ; obo:IAO_0000116 "check this. See also https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ; oboInOwl:hasDbXref "AAO:0000267", "EHDAA2:0000904" ; oboInOwl:hasExactSynonym "laryngeal cartilage system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010212" ; a owl:Class ; rdfs:label "laryngeal apparatus" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001739 ], _:genid150019 . obo:UBERON_0010213 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010213" ; a owl:Class ; rdfs:label "laryngeal pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid148135, _:genid150026, _:genid150028 . obo:UBERON_0010214 oboInOwl:hasDbXref "EHDAA2:0000327" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010214" ; a owl:Class ; rdfs:label "cricoid pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0010213 . obo:UBERON_0010215 obo:IAO_0000115 "Paired primordial elevations, on either side of the embryonic larynx, within which the arytenoid cartilages are formed." ; obo:UBPROP_0000012 "EHDAA2 and EMAPA appear to be inconsistent" ; oboInOwl:hasDbXref "EHDAA2:0000146" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010215" ; a owl:Class ; rdfs:label "arytenoid swellings" ; rdfs:subClassOf obo:UBERON_0005856, _:genid150031, _:genid150033 . obo:UBERON_0010219 oboInOwl:hasDbXref "EHDAA2:0004088" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010219" ; a owl:Class ; rdfs:label "thyroid pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0010213 . obo:UBERON_0010220 oboInOwl:hasDbXref "EHDAA2:0000144", "EMAPA:17387", "VHOG:0000998" ; oboInOwl:hasExactSynonym "arytenoid swelling pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010220" ; a owl:Class ; rdfs:label "arytenoid pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0010213, _:genid150037 . obo:UBERON_0010221 oboInOwl:hasDbXref "EHDAA2:0004085" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010221" ; a owl:Class ; rdfs:comment "Many sources say: thyroid cartilage from arch 4 other laryngeal cartilage (cricoid/arytenoid) from 6?" ; rdfs:label "laryngeal associated mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid148145, _:genid150041, _:genid150044, _:genid150046, _:genid150048 . obo:UBERON_0010222 oboInOwl:hasExactSynonym "inter-pupillary line", "interpupillary line" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010222" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anatomical line between pupils" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010223 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010224 ] ) ] . obo:UBERON_0010223 obo:IAO_0000115 "A pupil that is part of a left eye." ; oboInOwl:hasDbXref "FMA:58254", "SCTID:368597006" ; oboInOwl:hasExactSynonym "pupil of left eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010223" ; a owl:Class ; rdfs:label "left pupil" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004548 ] ) ] . obo:UBERON_0010224 obo:IAO_0000115 "A pupil that is part of a right eye." ; oboInOwl:hasDbXref "FMA:58253", "SCTID:368575009" ; oboInOwl:hasExactSynonym "pupil of right eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010224" ; a owl:Class ; rdfs:label "right pupil" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001771 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004549 ] ) ] . obo:UBERON_0010225 obo:IAO_0000115 "A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]." ; oboInOwl:hasDbXref "EHDAA2:0004469", "FMA:258745" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010225" ; a owl:Class ; rdfs:label "thalamic complex" ; rdfs:subClassOf obo:UBERON_0007245, _:genid150069 . obo:UBERON_0010227 obo:IAO_0000115 "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." ; oboInOwl:hasDbXref "FMA:71005", "TAO:0002228", "ZFA:0001718" ; oboInOwl:hasExactSynonym "presumptive atrium heart tube", "primordial atrium", "primordial cardiac atrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010227" ; a owl:Class ; rdfs:label "future cardiac atrium" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002081 ], _:genid150072 . obo:UBERON_0010230 obo:IAO_0000115 "The core globe-shaped component of the camera-type eye." ; obo:IAO_0000232 "See notes for camera-type eye" ; obo:UBPROP_0000202 obo:FMA_264089 ; oboInOwl:hasDbXref "FMA:12513", "MIAA:0000283", "SCTID:244486005", "VHOG:0001616", "Wikipedia:Globe_(human_eye)" ; oboInOwl:hasExactSynonym "bulbus oculi", "eye globe", "eyeball" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye", "globe" ; oboInOwl:id "UBERON:0010230" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "eyeball of camera-type eye" ; rdfs:subClassOf obo:UBERON_0000020, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid150079 . obo:UBERON_0010231 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inter-otic line", "inter-pinna line", "otic line" ; oboInOwl:id "UBERON:0010231" ; a owl:Class ; rdfs:label "anatomical line between outer ears" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148186 ] . obo:UBERON_0010233 obo:IAO_0000115 "The connective tissue that supports the lobules and follicles of the thyroid gland." ; oboInOwl:hasDbXref "FMA:86304", "SCTID:157862000" ; oboInOwl:hasExactSynonym "thyroid gland stroma", "thyroid stroma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010233" ; a owl:Class ; rdfs:label "stroma of thyroid gland" ; rdfs:subClassOf _:genid150097 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0010234 obo:IAO_0000115 "The palatopharyngeus or palatopharyngeal or pharyngopalatinus muscle is a long, fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the palatopharyngeal arch." ; obo:UBPROP_0000001 "Palatopharyngeus is a muscle that attaches to the palatine bones, soft palate, and pharynx and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" ; obo:UBPROP_0000010 "It is separated from the palatoglossus muscle by an angular interval, in which the palatine tonsil is lodged. It arises from the soft palate, where it is divided into two fasciculi by the levator veli palatini and musculus uvulae" ; oboInOwl:hasDbXref "FMA:46666", "SCTID:244796000", "Wikipedia:Palatopharyngeus_muscle" ; oboInOwl:hasExactSynonym "palatopharyngeal muscle", "palatopharyngeus", "pharyngopalatinus muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "musculus palatopharyngeus", "pharyngopalatinus" ; oboInOwl:id "UBERON:0010234" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "palatopharyngeus muscle" ; rdfs:subClassOf obo:UBERON_0000933, obo:UBERON_0003682, _:genid150103, _:genid150105, _:genid150107, _:genid150109, _:genid150111 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Musculuspalatopharyngeus.png"^^xsd:anyURI . obo:UBERON_0010235 obo:IAO_0000115 "The musculus uvulae (azygos uvulae) is a muscle of the soft palate. It arises from the posterior nasal spine of the palatine bones and from the palatine aponeurosis. It descends to be inserted into the uvula and functions to move and shape it. It is innervated by the pharyngeal branch of the vagus nerve via the pharyngeal plexus[WP]." ; obo:UBPROP_0000001 "The muscle of the uvuli is an integral part of the soft palate and is innervated by Cranial Nerve X .[FEED]" ; oboInOwl:hasDbXref "FMA:46733", "SCTID:244797009", "Wikipedia:Musculus_uvulae" ; oboInOwl:hasExactSynonym "uvular muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "azygos uvulae", "m. uvulae", "musculus uvulae", "musculus uvulae muscle", "uvulae muscle" ; oboInOwl:id "UBERON:0010235" ; a owl:Class ; rdfs:label "uvular muscle" ; rdfs:subClassOf obo:UBERON_0003682, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0014780 ], _:genid150124, _:genid150126 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001734 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray169.png"^^xsd:anyURI . obo:UBERON_0010243 obo:IAO_0000115 "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." ; obo:UBPROP_0000007 "merocrine" ; oboInOwl:hasDbXref "BTO:0002324", "MA:0003041", "Wikipedia:Merocrine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010243" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "merocrine gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002365 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006887 ] ) ] . obo:UBERON_0010252 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000037" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010252" ; a owl:Class ; rdfs:label "1st arch mandibular mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0010259, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007098 ], _:genid150149, _:genid150151 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid148234 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010253 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000044" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010253" ; a owl:Class ; rdfs:label "1st arch maxillary mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150162, _:genid150164 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010045 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010254 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000068", "EMAPA:16281" ; oboInOwl:hasExactSynonym "neural crest derived arch 2 mesenchyme", "pharyngeal arch 2 mesenchyme from neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 2 mesenchyme from neural crest" ; oboInOwl:id "UBERON:0010254" ; a owl:Class ; rdfs:label "2nd arch mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0007524, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007099 ], _:genid150174, _:genid150176 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010255 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000083", "EMAPA:16404", "VHOG:0000571" ; oboInOwl:hasExactSynonym "3rd pharyngeal arch mesenchyme derived from neural crest", "mesenchyme derived from neural crest of mesenchyme of 3rd arch", "neural crest derived arch 3 mesenchyme", "pharyngeal arch 3 mesenchyme from neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 3 mesenchyme from neural crest" ; oboInOwl:id "UBERON:0010255" ; a owl:Class ; rdfs:label "3rd arch mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150187, _:genid150189 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148265 ] . obo:UBERON_0010256 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme." ; obo:UBPROP_0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EHDAA2:0000098", "EMAPA:16772", "VHOG:0000580" ; oboInOwl:hasExactSynonym "4th pharyngeal arch mesenchyme derived from neural crest", "mesenchyme derived from neural crest of mesenchyme of 4th arch", "neural crest derived arch 4 mesenchyme", "pharyngeal arch 4 mesenchyme from neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 4 mesenchyme from neural crest" ; oboInOwl:id "UBERON:0010256" ; a owl:Class ; rdfs:label "4th arch mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150202, _:genid150204, _:genid150206 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005691 ] _:genid148281 ) ] . obo:UBERON_0010257 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004077" ; oboInOwl:hasExactSynonym "neural crest derived arch 6 mesenchyme", "pharyngeal arch 6 mesenchyme from neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 6 mesenchyme from neural crest" ; oboInOwl:id "UBERON:0010257" ; a owl:Class ; rdfs:label "6th arch mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150219, _:genid150221, _:genid150223 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010031 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010258 obo:IAO_0000115 "Mesenchyme that develops_from a rhombencephalon neural crest." ; oboInOwl:hasDbXref "EHDAA2:0004423" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010258" ; a owl:Class ; rdfs:label "mesenchyme from rhombencephalic neural crest" ; rdfs:subClassOf _:genid150230 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003852 ] ) ] . obo:UBERON_0010259 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." ; oboInOwl:hasDbXref "EMAPA:16129" ; oboInOwl:hasExactSynonym "mesenchyme derived from neural crest of mesenchyme of 1st arch", "neural crest derived arch 1 mesenchyme", "pharyngeal arch 1 mesenchyme from neural crest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 1 mesenchyme from neural crest" ; oboInOwl:id "UBERON:0010259" ; a owl:Class ; rdfs:label "1st arch mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150239 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010260 obo:IAO_0000115 "One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta." ; oboInOwl:hasDbXref "EMAPA:36493", "SCTID:408728001" ; oboInOwl:hasExactSynonym "allantoic vessel", "umbilical cord blood vessel", "umbilical vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "umbilical cord blood vessels", "umbilical vasculature" ; oboInOwl:id "UBERON:0010260" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "umbilical blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003422 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:UBERON_0010262 obo:IAO_0000115 "The most posterior portion of the inferior frontal gyrus of the frontal lobe in the brain. In an axial plane, the Sylvian fissure extends from the operculum posteriorly to divide the frontal from the temporal lobe. Broca's area is a notable part of the operculum, which plays a key role in conversation or speech production, reading and writing. Its vascular supply comes from the M3 branches of the middle cerebral artery[WP]." ; oboInOwl:hasBroadSynonym "operculum" ; oboInOwl:hasDbXref "SCTID:362351003", "Wikipedia:Operculum_(brain)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010262" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "operculum of brain" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016525 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Operculum.png"^^xsd:anyURI . obo:UBERON_0010272 obo:IAO_0000115 "A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage." ; obo:UBPROP_0000001 "Apparatus located in the floor of the mouth, under the mandibular arcade. The apparatus consists of a central corpus and four pairs of processes. This apparatus serves as the site of insertion for a variety of muscles associated with movements of the tongue and as the origin of the m. hyoglossus.[AAO]" ; obo:UBPROP_0000002 "relationship loss: part_of hyolaryngeal complex (AAO:0000226)[AAO]" ; obo:UBPROP_0000008 "In most mammals, including humans, the hyoid apparatus is shaped like a horseshoe. However, in humans, some of the bones of the hyoid apparatus are fused into a single bone called os hyoideum. In other animals such as frogs, the hyoid apparatus has a hyoid body that is chiefly comprised of hyaline cartilage and two pairs of processes (i.e. alary process and the posteriolateral process)." ; oboInOwl:hasDbXref "AAO:0000225", "AAO:0000682", "EMAPA:37600", "MA:0003037", "SCTID:410035009", "http://palaeos.com/vertebrates/bones/gill_arches/images/ReptileHyoids.gif" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "apparatus hyobranchialis", "apparatus hyoideus", "hyobranchial apparatus", "hyolingual system" ; oboInOwl:id "UBERON:0010272" ; a owl:Class ; rdfs:label "hyoid apparatus" ; rdfs:subClassOf obo:UBERON_0000075, _:genid150254 . obo:UBERON_0010273 obo:IAO_0000115 "A zone of bone organ that is part of a hyoid bone." ; oboInOwl:hasDbXref "FMA:59494", "SCTID:119534005" ; oboInOwl:hasExactSynonym "hyoid bone zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010273" ; a owl:Class ; rdfs:label "zone of hyoid bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001685 ] ) ] . obo:UBERON_0010276 obo:IAO_0000115 "Any anatomical space that is part of a vertebral column." ; oboInOwl:hasDbXref "AAO:0000700" ; oboInOwl:hasExactSynonym "vertebral column opening", "vertebral conduit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010276" ; a owl:Class ; rdfs:label "space in vertebral column" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ] ) ] . obo:UBERON_0010284 obo:IAO_0000115 "A minute orifice on the summit of the papillae lacrimales, which is the commencement point of the lacrimal canaliculi." ; obo:UBPROP_0000009 "collect tears produced by the lacrimal glands" ; oboInOwl:hasDbXref "FMA:59365", "SCTID:263344003", "Wikipedia:Lacrimal_punctum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lacrimal point", "lacrimal puncta", "puncta lacrimalia" ; oboInOwl:id "UBERON:0010284" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lacrimal punctum" ; rdfs:subClassOf obo:UBERON_0000161, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray895.png"^^xsd:anyURI . obo:UBERON_0010285 obo:IAO_0000115 "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." ; oboInOwl:hasDbXref "DHBA:12322", "EFO:0003567", "EHDAA2:0004375", "TAO:0000761", "ZFA:0000761" ; oboInOwl:hasExactSynonym "basal plate midbrain", "basal plate midbrain region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010285" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "midbrain basal plate" ; rdfs:subClassOf obo:UBERON_0002020, _:genid150283, _:genid150285 . obo:UBERON_0010286 obo:IAO_0000115 "Portion of neural tube that gives rise to the midbrain." ; obo:IAO_0000116 "we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed" ; oboInOwl:hasDbXref "TAO:0007039", "ZFA:0007039" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010286" ; a owl:Class ; rdfs:label "midbrain neural tube" ; rdfs:subClassOf obo:UBERON_0000479, _:genid150291 . obo:UBERON_0010291 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "Wikipedia:Sclera#Histology" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010291" ; a owl:Class ; rdfs:label "layer of sclera" ; rdfs:subClassOf obo:UBERON_0004923, _:genid150294 . obo:UBERON_0010294 obo:IAO_0000115 "An endothelium that is part of a sclera." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010294" ; a owl:Class ; rdfs:label "scleral endothelium" ; rdfs:subClassOf obo:UBERON_0010291 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] . obo:UBERON_0010295 obo:IAO_0000115 "A stroma that is part of a sclera." ; oboInOwl:hasBroadSynonym "subsantia propria" ; oboInOwl:hasDbXref "FMA:58365", "NCIT:C33652", "SCTID:368851004", "UMLS:C1704397" ; oboInOwl:hasExactSynonym "scleral stroma", "stroma of sclera", "subsantia propria sclerae", "substantia propria sclerae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010295" ; a owl:Class ; rdfs:label "substantia propria of sclera" ; rdfs:subClassOf obo:UBERON_0010291 ; owl:equivalentClass _:genid148372 . obo:UBERON_0010299 obo:IAO_0000115 "Mesenchyme surrounding the developing optic cup which develops into the sclera." ; obo:UBPROP_0000011 "The mesenchyme surrounding the developing optic cup differentiates into the sclera, the dense fibrous coat of the eye.. http://www.ncbi.nlm.nih.gov/pubmed/16496288" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010299" ; a owl:Class ; rdfs:label "scleral mesenchyme" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0003072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001773 ] ) ] . obo:UBERON_0010303 obo:IAO_0000115 "An epithelium that is part of a extraembryonic structure." ; oboInOwl:hasExactSynonym "extra-embryonic epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010303" ; a owl:Class ; rdfs:label "extraembryonic epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000478 ] ) ] . obo:UBERON_0010304 obo:IAO_0000115 "Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus." ; oboInOwl:hasDbXref "FMA:45569", "Wikipedia:Stratified_squamous_epithelium#Nonkeratinized" ; oboInOwl:hasExactSynonym "epithelium stratificatum squamosum noncornificatum", "nonkeratinizing stratified squamous epithelium", "stratified squamous non-keratinized epithelium", "stratified squamous nonkeratinizing epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010304" ; a owl:Class ; rdfs:label "non-keratinized stratified squamous epithelium" ; rdfs:subClassOf obo:UBERON_0006915 ; owl:disjointWith obo:UBERON_0012329 . obo:UBERON_0010305 obo:IAO_0000115 "One of the three major regions of the conjunctiva." ; oboInOwl:hasDbXref "FMA:59023", "SCTID:29445007", "Wikipedia:Conjunctiva#Gross_anatomy" ; oboInOwl:hasExactSynonym "conjunctiva region", "region of conjunctiva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010305" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "subdivision of conjunctiva" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000064 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:UBERON_0010306 obo:IAO_0000115 "The conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea." ; oboInOwl:hasDbXref "FMA:59024", "NCIT:C12902", "SCTID:264509009", "UMLS:C0229275" ; oboInOwl:hasExactSynonym "ocular conjunctiva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010306" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "covers the eyeball, over the sclera. This region of the conjunctiva is tightly bound to the underlying sclera by Tenon's capsule and moves with the eyeball movements." ; rdfs:label "bulbar conjunctiva" ; rdfs:subClassOf obo:UBERON_0010305, _:genid148407, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001772 ], _:genid148409 . obo:UBERON_0010309 obo:IAO_0000115 "An ossified element investing the upper eyelid." ; obo:IAO_0000116 "PMID:16496288 says 'invests' the eyelid, is this consistent across taxa?" ; obo:UBPROP_0000008 "The most extreme development of the palpebral is found in the armored dino- saur Euoplocephalus tutus, where the bone forms a quarter-sphere and adducts to completely occlude the or- bit (Coombs, 1972; Vickaryous and Russell, 2003). Notwithstanding the superficially similar position, palpe- brals and tarsal plates differ both anatomically and developmentally and are not considered homologous (Gauthier et al., 1988)" ; oboInOwl:hasBroadSynonym "palpebral" ; oboInOwl:hasDbXref "Wikipedia:Palpebral_(bone)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010309" ; a owl:Class ; rdfs:label "palpebral bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0010312 obo:IAO_0000115 "Developing anatomical structure that develops into the eyeball and associated structures." ; obo:UBPROP_0000001 "Multi-tissue structure that consists of the structures that develop into the retina and lens.[TAO]" ; oboInOwl:hasDbXref "TAO:0002201", "ZFA:0001678" ; oboInOwl:hasExactSynonym "future eye" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010312" ; a owl:Class ; rdfs:label "immature eye" ; rdfs:subClassOf _:genid150354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003071 ] ) ] . obo:UBERON_0010313 obo:IAO_0000115 "An anatomical structure that develops from the neural crest." ; obo:IAO_0000232 "Grouping term for query purposes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010313" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "neural crest-derived structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010314 obo:IAO_0000115 "An anatomical structure that has some part that develops from the neural crest." ; obo:IAO_0000232 "Grouping term for query purposes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010314" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "structure with developmental contribution from neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010316 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010316" ; a owl:Class ; rdfs:label "germ layer / neural crest" ; rdfs:subClassOf obo:UBERON_0000479, obo:UBERON_0002050, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002532 ] . obo:UBERON_0010321 obo:IAO_0000115 "A skeletal element that is part of a orbital region." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "eye skeleton", "ocular skeleton", "skeletal element of orbital region" ; oboInOwl:id "UBERON:0010321" ; a owl:Class ; rdfs:label "skeletal element of eye region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ], _:genid150375 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ) ] . obo:UBERON_0010323 obo:IAO_0000115 "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." ; obo:IAO_0000116 "we use 'cranial skeletal system', so that we can include the skull, which has joints/sutures as parts (recall, we follow FMA in distinguishing between the skeleton and skeletal system - only the latter includes joints)" ; obo:IAO_0000232 "that the cranial skeleton includes the pharyngeal arch skeleton. It is thus more inclusive that the cranium itself, and extends beyond the head in tetrapods. The AAO class called 'skull' belongs here, as it includes the whole splanchnocranium" ; obo:UBPROP_0000001 "Bony structure that encases the central nervous system and the primary sense organs of sight, olfaction, hearing, and equilibrium.[AAO]", "Skeletal system which is part of the skull, including the splanchnocranium, chondrocranium, and dermatocranium.[TAO]" ; oboInOwl:hasDbXref "AAO:0000109", "AAO:0000971", "AAO:0010185", "TAO:0000737", "VSAO:0000049", "XAO:0003075", "ZFA:0000737" ; oboInOwl:hasNarrowSynonym "cranial skeleton", "osteocranium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranium" ; oboInOwl:id "UBERON:0010323" ; a owl:Class ; rdfs:label "cranial skeletal system" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011137 ] . obo:UBERON_0010328 obo:IAO_0000115 "Mesenchyme that is part of a limb bud." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010328" ; a owl:Class ; rdfs:label "limb bud mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004347 ] ) ] . obo:UBERON_0010329 obo:IAO_0000115 "Mesenchyme that is part of a limb/fin bud." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010329" ; a owl:Class ; rdfs:label "paired limb/fin bud mesenchyme" ; rdfs:subClassOf _:genid150392 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004357 ] ) ] . obo:UBERON_0010330 obo:IAO_0000115 "Mesenchyme that is part of a developing eyelid." ; oboInOwl:hasDbXref "EMAPA:32759" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010330" ; a owl:Class ; rdfs:label "eyelid mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0010332 obo:IAO_0000115 "An epithelium that is part of a handplate." ; oboInOwl:hasDbXref "EHDAA2:0000730", "EMAPA:32630" ; oboInOwl:hasExactSynonym "handplate epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010332" ; a owl:Class ; rdfs:label "epithelium of handplate" ; rdfs:subClassOf obo:UBERON_0000490, _:genid150405 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006875 ] ) ] . obo:UBERON_0010333 obo:IAO_0000115 "Mesenchyme that is part of a extraembryonic membrane." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010333" ; a owl:Class ; rdfs:label "extraembryonic membrane mesenchyme" ; rdfs:subClassOf _:genid150413 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005631 ] ) ] . obo:UBERON_0010334 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004601" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010334" ; a owl:Class ; rdfs:label "maxillary process mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150423, _:genid150425 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009526 ] _:genid148484 ) ] . obo:UBERON_0010335 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004602" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010335" ; a owl:Class ; rdfs:label "maxillary process mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150435, _:genid150437 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009526 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010336 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004603" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010336" ; a owl:Class ; rdfs:label "mandibular process mesenchyme from neural crest" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150447, _:genid150449 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) ] . obo:UBERON_0010337 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004604" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010337" ; a owl:Class ; rdfs:label "mandibular process mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150459, _:genid150461 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010338 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000043" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010338" ; a owl:Class ; rdfs:label "1st arch maxillary mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150471, _:genid150473 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010045 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010339 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000036" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010339" ; a owl:Class ; rdfs:label "1st arch mandibular mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150483, _:genid150485 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid148532 _:genid148534 ) ] . obo:UBERON_0010341 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." ; oboInOwl:hasDbXref "EMAPA:16130" ; oboInOwl:hasExactSynonym "mesenchyme derived from head mesoderm of mesenchyme of 1st arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010341" ; a owl:Class ; rdfs:label "1st arch mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0003104, _:genid150495 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148541 ] . obo:UBERON_0010343 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000067", "EMAPA:16280" ; oboInOwl:hasExactSynonym "head mesenchyme derived arch 2 mesenchyme", "mesenchyme derived from head mesoderm of mesenchyme of 2nd arch", "pharyngeal arch 2 mesenchyme from head mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 2 mesenchyme from head mesenchyme" ; oboInOwl:id "UBERON:0010343" ; a owl:Class ; rdfs:label "2nd arch mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150506, _:genid150508 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005689 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010344 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000082", "EMAPA:16403" ; oboInOwl:hasExactSynonym "head mesenchyme derived arch 3 mesenchyme", "mesenchyme derived from head mesoderm of mesenchyme of 3rd arch", "pharyngeal arch 3 mesenchyme from head mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 3 mesenchyme from head mesenchyme" ; oboInOwl:id "UBERON:0010344" ; a owl:Class ; rdfs:label "3rd arch mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150519, _:genid150521 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010345 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000097", "EMAPA:16771" ; oboInOwl:hasExactSynonym "head mesenchyme derived arch 4 mesenchyme", "mesenchyme derived from head mesoderm of mesenchyme of 4th arch", "pharyngeal arch 4 mesenchyme from head mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 4 mesenchyme from head mesenchyme" ; oboInOwl:id "UBERON:0010345" ; a owl:Class ; rdfs:label "4th arch mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150532, _:genid150534 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005691 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010347 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0004078" ; oboInOwl:hasExactSynonym "head mesenchyme derived arch 6 mesenchyme", "pharyngeal arch 6 mesenchyme from head mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "branchial arch 6 mesenchyme from head mesenchyme" ; oboInOwl:id "UBERON:0010347" ; a owl:Class ; rdfs:label "6th arch mesenchyme from head mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150545, _:genid150547 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010031 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010348 oboInOwl:hasDbXref "EHDAA2:0000795" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hyoid muscle plate" ; oboInOwl:id "UBERON:0010348" ; a owl:Class ; rdfs:label "hyoid pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid150551 . obo:UBERON_0010349 obo:IAO_0000115 "An otic capsule endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0000833" ; oboInOwl:hasExactSynonym "otic capsule anlage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010349" ; a owl:Class ; rdfs:label "otic capsule pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004637 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010354 oboInOwl:hasDbXref "EMAPA:17351" ; oboInOwl:hasExactSynonym "future Reichert's cartilage", "hyoid cartilage pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010354" ; a owl:Class ; rdfs:label "Reichert's cartilage pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid150559 . obo:UBERON_0010355 obo:IAO_0000115 "The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed a ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between two cells of the same row also becomes calcified, and transverse bars of calcified substance stretch across from one calcareous column to another. Thus there are longitudinal groups of the cartilage cells enclosed in oblong cavities, the walls of which are formed of calcified matrix which cuts off all nutrition from the cells; the cells, in consequence, atrophy, leaving spaces called the primary areolC&." ; obo:IAO_0000116 "currently classified as a zone of a bone organ, but exists prior to bone ossifying" ; oboInOwl:hasDbXref "FMA:75436", "Wikipedia:Ossification_center" ; oboInOwl:hasExactSynonym "centrum ossificationis", "ossification centre" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "center of ossification", "centrum ossificationis" ; oboInOwl:id "UBERON:0010355" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ossification center" ; rdfs:subClassOf obo:UBERON_0005913 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fd/Gray79.png"^^xsd:anyURI . obo:UBERON_0010358 obo:IAO_0000115 "An arch-shaped structure of the vertebra that extends dorsally (neural arch) or ventrally (hemal arch) from the vertebral centrum." ; obo:UBPROP_0000003 "(...) certain common components [of vertebral structure] are found in nearly all vertebrate. A representative vertebra has a vertebral arch or neural arch, which extends dorsally around the spinal cord.[well established][VHOG]" ; obo:UBPROP_0000012 "Note that humans do not have hemal arches, so VA=NA for FMA" ; oboInOwl:hasDbXref "EMAPA:36614", "FMA:11946" ; oboInOwl:hasNarrowSynonym "arch of vertebra", "arcus vertebrae (vertebralis)", "vertebra arch", "vertebral arch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010358" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "arch of centrum of vertebra" ; rdfs:subClassOf obo:UBERON_0004765, _:genid150568 . obo:UBERON_0010359 obo:IAO_0000115 "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." ; oboInOwl:hasExactSynonym "arch mesenchyme from neural crest", "branchial arch mesenchyme from neural crest", "neural crest derived arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010359" ; a owl:Class ; rdfs:comment "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ; rdfs:label "pharyngeal arch mesenchyme from neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010046 ] _:genid148621 ) ] . obo:UBERON_0010360 obo:IAO_0000115 "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." ; oboInOwl:hasExactSynonym "arch mesenchyme from head mesenchyme", "branchial arch mesenchyme from head mesenchyme", "head mesenchyme derived arch mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010360" ; a owl:Class ; rdfs:comment "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ; rdfs:label "pharyngeal arch mesenchyme from head mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010046 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) ] . obo:UBERON_0010362 obo:IAO_0000115 "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." ; obo:UBPROP_0000001 "An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t" ; oboInOwl:hasDbXref "VSAO:0000037", "Wikipedia:Endoskeleton", "XAO:0004026" ; oboInOwl:hasExactSynonym "replacement skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010362" ; a owl:Class ; rdfs:label "endoskeleton" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0010522 ] . obo:UBERON_0010363 obo:IAO_0000115 "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." ; oboInOwl:hasDbXref "VSAO:0000139", "XAO:0004017", "ZFA:0005620" ; oboInOwl:hasExactSynonym "endochondral replacement element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010363" ; a owl:Class ; rdfs:label "endochondral element" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0004765 . obo:UBERON_0010364 obo:IAO_0000115 "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." ; oboInOwl:hasBroadSynonym "exoskeleton" ; oboInOwl:hasDbXref "VSAO:0000035", "XAO:0004025" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermal skeletal system", "dermoskeleton", "desmoskeleton" ; oboInOwl:id "UBERON:0010364" ; a owl:Class ; rdfs:comment "This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO" ; rdfs:label "dermal skeleton" ; rdfs:subClassOf obo:UBERON_0010912 . obo:UBERON_0010365 obo:IAO_0000115 "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." ; obo:UBPROP_0000008 "in many vertebrates, odontoid tissue is not restricted to the teeth" ; obo:UBPROP_0000012 "Classified as a portion of organism substance in FMA" ; oboInOwl:hasAlternativeId "UBERON:0001973" ; oboInOwl:hasDbXref "EMAPA:35872", "FMA:63001", "MA:0002540", "NCIT:C33794", "UMLS:C1519551", "VSAO:0000063", "XAO:0004046", "ZFA:0005623" ; oboInOwl:hasExactSynonym "odontogenic tissue" ; oboInOwl:hasNarrowSynonym "portion of substance of tooth", "substance of tooth", "tooth substance" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dental tissue", "tooth hard tissue", "tooth tissue" ; oboInOwl:id "UBERON:0010365" ; oboInOwl:inSubset core:uberon_slim ; a owl:Class ; rdfs:label "odontoid tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004755 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010364 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001763 ] ) ] . obo:UBERON_0010366 obo:IAO_0000115 "A vasculature that is part of a conjunctiva." ; oboInOwl:hasDbXref "FMA:70887" ; oboInOwl:hasExactSynonym "conjunctival veins", "conjunctival veins set", "set of conjunctival veins", "venae conjunctivales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010366" ; a owl:Class ; rdfs:label "conjunctival vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:UBERON_0010367 obo:IAO_0000115 "A vein that is part of a conjunctiva." ; oboInOwl:hasBroadSynonym "conjunctival blood vessel" ; oboInOwl:hasDbXref "FMA:70887", "SCTID:149885003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010367" ; a owl:Class ; rdfs:label "conjunctival vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010366 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148671 ] . obo:UBERON_0010368 obo:IAO_0000115 "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." ; oboInOwl:hasDbXref "FMA:75739", "NCIT:C33428" ; oboInOwl:hasExactSynonym "lobulus pulmonis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010368" ; a owl:Class ; rdfs:label "pulmonary lobule" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002187 ] ; owl:equivalentClass _:genid148676 . obo:UBERON_0010370 obo:IAO_0000115 "One of the veins of the lower leg; empty into the popliteal vein." ; oboInOwl:hasDbXref "EMAPA:37199", "MA:0002243", "NCIT:C33787", "UMLS:C0447138" ; oboInOwl:hasExactSynonym "vena tibialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010370" ; a owl:Class ; rdfs:label "tibial vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] . obo:UBERON_0010371 obo:IAO_0000115 "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." ; oboInOwl:hasDbXref "FMA:69064" ; oboInOwl:hasExactSynonym "ectoderm-derived epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010371" ; a owl:Class ; rdfs:label "ecto-epithelium" ; rdfs:subClassOf _:genid148692 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0010375 obo:IAO_0000116 "consider merging with dorsal pancreatic bud. Starts at CS12 in human (EHDAA2, embryology.ch 'bud anlagen')" ; oboInOwl:hasDbXref "EHDAA2:0001384", "FMA:79793" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal pancreas" ; oboInOwl:id "UBERON:0010375" ; a owl:Class ; rdfs:label "pancreas dorsal primordium" ; rdfs:subClassOf _:genid150658 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148695 ] . obo:UBERON_0010376 obo:UBPROP_0000008 "Starts at CS14 in human (EHDAA2) or CS13-14 (embryology.ch 'bud anlagen')" ; oboInOwl:hasDbXref "EHDAA2:0001387", "FMA:79794" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventral pancreas" ; oboInOwl:id "UBERON:0010376" ; a owl:Class ; rdfs:label "pancreas ventral primordium" ; rdfs:subClassOf _:genid150665 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0009709 ] ) ] . obo:UBERON_0010377 obo:IAO_0000115 "Mesenchyme that develops_from a somatopleure." ; obo:IAO_0000116 "the way this class is defined also includes extraembryonic mesenchyme such as the amniotic mesenchyme; in future this may be restricted to embryonic derivatives" ; oboInOwl:hasDbXref "EHDAA2:0001120" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010377" ; a owl:Class ; rdfs:label "mesenchyme from somatopleure" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150675 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 _:genid148708 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004874 ] ) ] . obo:UBERON_0010378 obo:IAO_0000115 "Mesenchyme that develops_from a splanchnopleure." ; oboInOwl:hasDbXref "EHDAA2:0001122" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010378" ; a owl:Class ; rdfs:label "mesenchyme from splanchnopleure" ; rdfs:subClassOf obo:UBERON_0007524, _:genid150685 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148716 ] . obo:UBERON_0010379 obo:IAO_0000115 "The superior tarsal muscle is a smooth muscle adjoining the levator palpebrae superioris muscle that helps to raise the upper eyelid." ; obo:IAO_0000116 "declaring this to be both smooth muscle and part of the LPS leads to a disjointness violation (smooth muscle and striated muscle)" ; oboInOwl:hasDbXref "FMA:49058", "SCTID:244775007", "Wikipedia:Superior_tarsal_muscle" ; oboInOwl:hasExactSynonym "Mueller's muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Muller's muscle", "Müller's muscle", "mueller muscle", "musculus tarsalis superior", "the superior tarsal muscle" ; oboInOwl:id "UBERON:0010379" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "superior tarsal muscle" ; rdfs:subClassOf _:genid150692, _:genid150694, _:genid150696 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148725 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6f/Gray894.png"^^xsd:anyURI . obo:UBERON_0010380 obo:IAO_0000115 "The neurons that innervate the esophagus, stomach, small and large bowel." ; oboInOwl:hasDbXref "EMAPA:37479", "MA:0001145" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010380" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "enteric nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002005 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002005 ] ) ] . obo:UBERON_0010384 obo:IAO_0000115 "An anatomical space that is enclosed by a hypopharynx." ; oboInOwl:hasDbXref "FMA:55096" ; oboInOwl:hasExactSynonym "laryngopharynx lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010384" ; a owl:Class ; rdfs:label "lumen of laryngopharynx" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001731 ], _:genid150716 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001051 ] ) ] . obo:UBERON_0010388 obo:IAO_0000115 "The segment of the rib that connects to a vertebra[MP]. a small part of the rib composed of the head, neck, tuberculum and a short proximal part of the body[PMID]." ; oboInOwl:hasDbXref "EMAPA:37495", "MA:0001400", "MA:0001414" ; oboInOwl:hasExactSynonym "proximal part of rib", "proximal rib", "proximal rib segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "costal part of rib", "vertebral part of rib" ; oboInOwl:id "UBERON:0010388" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "The proximal rib derives from the caudal half of somite[PMID:15906248]" ; rdfs:label "proximal segment of rib" ; rdfs:subClassOf obo:UBERON_0005913, _:genid148753, _:genid150721 . obo:UBERON_0010390 obo:IAO_0000115 "An organ cavity that is part of a urethra." ; oboInOwl:hasDbXref "FMA:19709", "SCTID:279432008" ; oboInOwl:hasExactSynonym "urethral lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010390" ; a owl:Class ; rdfs:label "lumen of urethra" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ; owl:equivalentClass _:genid148759 . obo:UBERON_0010395 obo:IAO_0000115 "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." ; oboInOwl:hasDbXref "EMAPA:35530", "FMA:312350", "MA:0000743" ; oboInOwl:hasExactSynonym "primary follicle of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010395" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lymph node primary follicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010422 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_0010399 obo:IAO_0000115 "One of the branches of the splenic artery[MP]." ; obo:UBPROP_0000001 "When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia]" ; oboInOwl:hasDbXref "MA:0000759", "NCIT:C49775", "UMLS:C1710159", "Wikipedia:Trabecular_arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trabecular artery" ; oboInOwl:id "UBERON:0010399" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen trabecular artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002106 ], _:genid150744 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001265 ] ) ] . obo:UBERON_0010400 obo:IAO_0000115 "One of the veins that feed the splenic vein." ; obo:UBPROP_0000001 "The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia]" ; oboInOwl:hasDbXref "MA:0000760", "NCIT:C49779", "UMLS:C1710160", "Wikipedia:Trabecular_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "trabecular vein" ; oboInOwl:id "UBERON:0010400" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen trabecular vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0003713 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001265 ] ) ] . obo:UBERON_0010402 obo:IAO_0000115 "Any layer of the epidermis that is superior to the stratum basale." ; oboInOwl:hasBroadSynonym "suprabasal layer" ; oboInOwl:hasDbXref "EMAPA:35315", "MA:0000808" ; oboInOwl:hasExactSynonym "suprabasal cell layer of skin", "suprabasal layer of epidermis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010402" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epidermis suprabasal layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0002025 ] ) ] . obo:UBERON_0010408 obo:IAO_0000115 "The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein." ; oboInOwl:hasDbXref "EMAPA:37673", "FMA:49583", "MA:0002010", "NCIT:C32076", "SCTID:145238006", "UMLS:C0226116" ; oboInOwl:hasExactSynonym "angular artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010408" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ocular angle artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001612 ] . obo:UBERON_0010409 obo:IAO_0000115 "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." ; oboInOwl:hasDbXref "EMAPA:35336", "MA:0002486" ; oboInOwl:hasExactSynonym "eye surface", "eye surface region", "ocular surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010409" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ocular surface region" ; rdfs:subClassOf obo:UBERON_0000063, _:genid148803, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0022288 ] . obo:UBERON_0010411 obo:IAO_0000115 "Encapsulated adipose tissue found on the dorsal side of the peritoneum." ; oboInOwl:hasDbXref "MA:0002549" ; oboInOwl:hasExactSynonym "retroperitoneal fat depot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010411" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "retroperitoneal fat pad" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003693 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 ] ) ] . obo:UBERON_0010412 obo:IAO_0000115 "Encapsulated adipose tissue associated with the epididymis." ; oboInOwl:hasDbXref "EMAPA:35316", "MA:0002550" ; oboInOwl:hasExactSynonym "periepididymal fat pad" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010412" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epididymal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148814 ] . obo:UBERON_0010418 obo:IAO_0000115 "An orifice that is part of a lower urinary tract." ; oboInOwl:hasDbXref "EMAPA:35965", "MA:0002867" ; oboInOwl:hasExactSynonym "urethral orifice" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010418" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "urethral opening" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001556 ] ) ] . obo:UBERON_0010420 obo:IAO_0000115 "A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it." ; oboInOwl:hasBroadSynonym "germinal center mantle zone", "mantle zone of germinal center" ; oboInOwl:hasDbXref "EMAPA:37661", "MA:0002990" ; oboInOwl:hasExactSynonym "lymph node B cell corona", "lymph node follicular corona", "lymph node follicular mantle", "lymph node inactive zone", "lymph node peripheral zone", "mantle zone of lymph node germinal center" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymph node dark zone" ; oboInOwl:id "UBERON:0010420" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lymph node germinal center mantle zone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0009039 ], _:genid150799 ; owl:equivalentClass _:genid148825 . obo:UBERON_0010421 obo:IAO_0000115 "The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes." ; oboInOwl:hasBroadSynonym "B cell domain of the spleen", "B lymphocyte domain of the spleen", "lymphocytic corona", "splenic corona" ; oboInOwl:hasDbXref "EMAPA:37962" ; oboInOwl:hasExactSynonym "follicle mantle", "spleen B cell corona", "spleen B-cell corona", "spleen lymphocytic corona", "splenic B cell corona" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spleen mantle zone" ; oboInOwl:id "UBERON:0010421" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "spleen B cell corona" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0005196 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004042 ], _:genid150813 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010755 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0010422 obo:IAO_0000115 "A lymphoid follicle containing naive B cells." ; obo:UBPROP_0000015 "The cortex of lymph nodes, the white pulp of spleen, and mucosa associated lymphoid tissue all have these primary follicles" ; oboInOwl:hasDbXref "FMA:55223" ; oboInOwl:hasExactSynonym "primary lymphoid follicle", "primary lymphoid nodule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "primary follicle" ; oboInOwl:id "UBERON:0010422" ; a owl:Class ; rdfs:label "primary nodular lymphoid tissue" ; rdfs:subClassOf obo:UBERON_0000444, _:genid150829 . obo:UBERON_0010423 obo:IAO_0000115 "A primary nodular lymphoid tissue that is part of a tonsil." ; oboInOwl:hasDbXref "FMA:86018" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymphoid nodule of tonsil" ; oboInOwl:id "UBERON:0010423" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "primary lymphoid nodule of tonsil" ; rdfs:subClassOf obo:UBERON_0010422 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010422 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:UBERON_0010424 oboInOwl:hasDbXref "EMAPA:37492", "MA:0001397", "MA:0001418" ; oboInOwl:hasExactSynonym "distal part of rib", "distal rib", "distal rib segment" ; oboInOwl:hasNarrowSynonym "sternal rib", "vertical segment of rib" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010424" ; a owl:Class ; rdfs:comment "The distal rib derives from both somite halves[PMID:15906248]" ; rdfs:label "distal segment of rib" ; rdfs:subClassOf obo:UBERON_0005913, _:genid150840 . obo:UBERON_0010425 obo:IAO_0000115 "A naris that is located inside the nasal cavity and connects to the pharynx." ; obo:UBPROP_0000007 "choanal" ; obo:UBPROP_0000008 "In humans the only internal naris is the posterior nasal aperture, which connects to the nasopharynx" ; obo:UBPROP_0000202 obo:FMA_76585 ; oboInOwl:hasDbXref "NCIT:C32856" ; oboInOwl:hasExactSynonym "choana", "internal choana" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "choanae", "internal nares", "internal nostril" ; oboInOwl:id "UBERON:0010425" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "internal naris" ; owl:equivalentClass _:genid148871 . obo:UBERON_0010427 obo:IAO_0000115 "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." ; oboInOwl:hasDbXref "FMA:76551", "SCTID:280860001", "Wikipedia:Ciliary_processes" ; oboInOwl:hasExactSynonym "ciliary processes", "ciliary processes set", "processus ciliares", "set of ciliary processes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ciliary process", "processus ciliares" ; oboInOwl:id "UBERON:0010427" ; a owl:Class ; rdfs:label "ciliary processes" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png"^^xsd:anyURI . obo:UBERON_0010428 obo:IAO_0000115 "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." ; obo:UBPROP_0000008 "In an adult mammal, most red blood cells are formed in flat bones" ; obo:UBPROP_0000009 "Flat bones are those bones which are found where the principal requirement is either extensive protection or the provision of broad surfaces for muscular attachment" ; oboInOwl:hasDbXref "FMA:7476", "NCIT:C32616", "SCTID:332907008", "UMLS:C0222649", "Wikipedia:Flat_bone", "galen:FlatBone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "os planum" ; oboInOwl:id "UBERON:0010428" ; a owl:Class ; rdfs:comment "Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs" ; rdfs:label "flat bone" ; rdfs:subClassOf obo:UBERON_0001474, _:genid148888 . obo:UBERON_0010437 obo:IAO_0000115 "One of: zygomaticus major, zygomaticus minor." ; oboInOwl:hasDbXref "EMAPA:37703", "MA:0002404", "NCIT:C53182", "UMLS:C1710708" ; oboInOwl:hasExactSynonym "m. zygomaticus", "zygomaticus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "m. levator nasii" ; oboInOwl:id "UBERON:0010437" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "origin: posterior braincase" ; rdfs:label "zygomaticus muscle" ; rdfs:subClassOf obo:UBERON_0001577, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ], _:genid150872, _:genid150874 ; owl:equivalentClass [ a owl:Class ; owl:unionOf _:genid148894 ] . obo:UBERON_0010498 obo:IAO_0000115 "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." ; obo:UBPROP_0000009 "Pseudostratified epithelia function in secretion or absorption. If a specimen looks stratified but has cilia, then it is a pseudostratified ciliated epithelium, since stratified epithelia do not have cilia." ; obo:UBPROP_0000012 "glandular in NCIT; we consider the two NCIT terms synonymous" ; oboInOwl:hasDbXref "FMA:45572", "NCIT:C33419", "NCIT:C49316", "UMLS:C0836138", "UMLS:C1514590", "Wikipedia:Pseudostratified_columnar_epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010498" ; a owl:Class ; rdfs:label "pseudostratified columnar epithelium" ; rdfs:subClassOf obo:UBERON_0000485 . obo:UBERON_0010499 obo:IAO_0000115 "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." ; oboInOwl:hasDbXref "FMA:13146", "NCIT:C13181", "UMLS:C0506992" ; oboInOwl:hasExactSynonym "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010499" ; a owl:Class ; rdfs:label "pseudostratified ciliated columnar epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010498 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000067 ] ) ] . obo:UBERON_0010522 obo:IAO_0000115 "Skeletal element that forms as a replacement or substitution of another element or tissue." ; oboInOwl:hasDbXref "VSAO:0000135", "XAO:0004016", "ZFA:0005624" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010522" ; a owl:Class ; rdfs:label "replacement element" ; rdfs:subClassOf obo:UBERON_0004765, _:genid150893 . obo:UBERON_0010523 obo:IAO_0000115 "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." ; oboInOwl:hasDbXref "MESH:D055806", "TAO:0005251", "ZFA:0005251" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "microcirculatory vessels" ; oboInOwl:id "UBERON:0010523" ; a owl:Class ; rdfs:label "microcirculatory vessel" ; rdfs:subClassOf obo:UBERON_0000055, _:genid150896 . obo:UBERON_0010527 obo:IAO_0000115 "An organ cavity that surrounded_by a bone." ; oboInOwl:hasDbXref "FMA:24021" ; oboInOwl:hasExactSynonym "bone organ cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010527" ; a owl:Class ; rdfs:label "cavity of bone organ" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_0010528 oboInOwl:hasDbXref "FMA:24028" ; oboInOwl:hasExactSynonym "air space of bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010528" ; a owl:Class ; rdfs:label "pneumatic cavity of bone" ; rdfs:subClassOf obo:UBERON_0010527, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008193 ] . obo:UBERON_0010531 obo:IAO_0000115 "." ; obo:UBPROP_0000012 "different versions of EMAPA have different labels for the same classes. In vHOG this is part of metanephros cortex but this leads to a cycle in basic." ; oboInOwl:hasDbXref "EHDAA2:0001143", "EHDAA:7007", "EHDAA:8105", "EMAPA:17953", "EMAPA:27621", "MA:0002998", "VHOG:0001241" ; oboInOwl:hasExactSynonym "induced blastemal cells", "nephrogenic interstitium of nephrogenic zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cap mesenchyme of metanephros of urinary system", "nephrogenic interstitium", "peripheral blastema" ; oboInOwl:id "UBERON:0010531" ; a owl:Class ; rdfs:label "metanephros induced blastemal cells" ; rdfs:subClassOf obo:UBERON_0005423, _:genid148931, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000354 ], _:genid148933, _:genid150911 . obo:UBERON_0010532 obo:IAO_0000115 "An epithelial tube that is fated to become a nephron." ; obo:UBPROP_0000012 "EHDAA2 treats this as already having a tubular structure, but in the ZFA representation this is a cluster of cells" ; oboInOwl:hasBroadSynonym "developing nephron", "primitive nephron" ; oboInOwl:hasExactSynonym "future nephron", "presumptive nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010532" ; a owl:Class ; rdfs:label "primitive nephron" ; rdfs:subClassOf obo:UBERON_0003914, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003918 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001285 ], _:genid150923 . obo:UBERON_0010533 obo:IAO_0000115 "The metanephric cortex is the outer region of the metanephros[GO]." ; oboInOwl:hasDbXref "VHOG:0000714" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010533" ; a owl:Class ; rdfs:label "metanephros cortex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005113 ], _:genid150932 ; owl:equivalentClass _:genid148948 . obo:UBERON_0010534 obo:IAO_0000115 "Anatomical cluster which give rise to mature mesonephric nephrons. Zebrafish continously generate new mesonephric nephrons." ; oboInOwl:hasDbXref "ZFA:0005584" ; oboInOwl:hasExactSynonym "developing mesonephric nephron", "primitive mesonephric nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010534" ; a owl:Class ; rdfs:label "primitive mesonephric nephron" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid148956 ] . obo:UBERON_0010535 obo:IAO_0000115 "A primitive nephron that is part of a metanephros." ; oboInOwl:hasBroadSynonym "primitive nephron" ; oboInOwl:hasDbXref "EHDAA2:0001516" ; oboInOwl:hasExactSynonym "developing metanephric nephron", "primitive metanephric nephron" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010535" ; a owl:Class ; rdfs:label "primitive metanephric nephron" ; rdfs:subClassOf _:genid150946 ; owl:equivalentClass _:genid148961 . obo:UBERON_0010536 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010536" ; a owl:Class ; rdfs:label "nephron progenitor" ; rdfs:subClassOf obo:UBERON_0000479, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001285 ], _:genid150951 . obo:UBERON_0010537 obo:IAO_0000115 "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." ; oboInOwl:hasDbXref "ZFA:0005587" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010537" ; a owl:Class ; rdfs:label "mesonephric nephron progenitor" ; owl:equivalentClass _:genid148971 . obo:UBERON_0010538 obo:IAO_0000115 "An appendage segment that is part of a limb/fin." ; oboInOwl:hasExactSynonym "limb/fin segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010538" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "paired limb/fin segment" ; owl:disjointWith obo:UBERON_0010912 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010758 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004708 ] ) ] . obo:UBERON_0010540 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a tarsal bone." ; oboInOwl:hasDbXref "EHDAA2:0001978" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010540" ; a owl:Class ; rdfs:label "tarsus pre-cartilage condensation" ; rdfs:subClassOf _:genid148985, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010695 ], _:genid150968 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] . obo:UBERON_0010541 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a tarsal bone." ; oboInOwl:hasDbXref "EHDAA2:0001977" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010541" ; a owl:Class ; rdfs:label "tarsus cartilage element" ; rdfs:subClassOf _:genid148994, _:genid150978, _:genid150980, _:genid150983 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005863 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001447 ] ) ] . obo:UBERON_0010543 obo:IAO_0000115 "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]." ; oboInOwl:hasDbXref "FMA:231315", "VSAO:0005028" ; oboInOwl:hasExactSynonym "acropodial skeleton", "acropodium skeleton", "set of phalanges", "skeletal parts of acropodial region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acropodium", "digital skeleton", "digits skeleton", "phalangeal skeleton", "skeletal parts of acropodium", "skeleton of digits" ; oboInOwl:id "UBERON:0010543" ; a owl:Class ; rdfs:label "acropodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012354 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0015023 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0010546 ], _:genid150990 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0012354 ] ) ] . obo:UBERON_0010544 obo:IAO_0000115 "The metacarpus is the intermediate part of the manus skeleton that is located between the phalanges (bones of the fingers) distally and the carpus which forms the connection to the forearm. The metacarpus consists of metacarpal bones. The metacarpals form a transverse arch to which the rigid row of distal carpal bones are fixed. The peripheral metacarpals (those of the thumb and little finger) form the sides of the cup of the palmar gutter and as they are brought together they deepen this concavity. The index metacarpal is the most firmly fixed, while the thumb metacarpal articulates with the trapezium and acts independently from the others. The middle metacarpals are tightly united to the carpus by intrinsic interlocking bone elements at their bases. The ring metacarpal forms a transitional element of the semi-independent last metacarpal. [WP,unvetted]." ; obo:UBPROP_0000001 "Segment of the forearm corresponding to the metacarpus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" ; oboInOwl:hasDbXref "AAO:0000946", "EMAPA:36158", "FMA:71336", "MESH:D050279", "VSAO:0005026", "Wikipedia:Metacarpus", "XAO:0003208" ; oboInOwl:hasExactSynonym "anterior metapodial skeleton", "metacarpal bones", "metacarpal skeleton", "metacarpals [I-V]", "metacarpals set", "ossa metacarpalia [I-V]", "ossa metacarpi [I-V]", "set of metacarpal bones", "set of metacarpals", "set of metacarpals [I-V]", "skeleton of metacarpus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior metapodium", "fore metapodial skeleton", "fore metapodium", "metacarpalia" ; oboInOwl:id "UBERON:0010544" ; a owl:Class ; rdfs:label "metacarpus skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004453 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0009880 ], _:genid151003, _:genid151005 ; owl:disjointWith obo:UBERON_0010545 ; owl:equivalentClass _:genid149010 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg"^^xsd:anyURI . obo:UBERON_0010545 obo:IAO_0000115 "Limb segment that consists of the long bones of the pes. The metatarsals are analogous to the metacarpal bones of the manus." ; obo:UBPROP_0000001 "Segment of the leg corresponding to the metatarsus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" ; oboInOwl:hasDbXref "AAO:0000221", "FMA:71340", "MESH:D008684", "VSAO:0005027", "Wikipedia:Metatarsus", "XAO:0003212" ; oboInOwl:hasExactSynonym "metatarsal bones set", "metatarsal skeleton", "metatarsals [I-V]", "ossa metatarsalia [I-V]", "ossa metatarsi[I-V]", "posterior metapodial skeleton", "set of metatarsal bones", "set of metatarsals [I-V]", "skeleton of metatarsus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsalia", "ossa metatarsalia", "posterior metapodium" ; oboInOwl:id "UBERON:0010545" ; a owl:Class ; rdfs:label "metatarsus skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000983 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0009879 ], _:genid151027, _:genid151029 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0000983 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png"^^xsd:anyURI . obo:UBERON_0010546 obo:IAO_0000115 "Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton." ; obo:UBPROP_0000001 "Endochondral bone complex located between the mesopodium and the acropodium and consisting of the metacarpals or metatarsals.[VSAO]" ; obo:UBPROP_0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: connected_to subdivision of skeleton (UBERON:0010912)[VSAO]", "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" ; oboInOwl:hasDbXref "VSAO:0005025" ; oboInOwl:hasExactSynonym "metacarpal/metatarsal skeleton", "metapodial skeleton", "metapodium skeleton", "skeletal parts of metapodium", "skeleton of metapodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metapodium" ; oboInOwl:id "UBERON:0010546" ; a owl:Class ; rdfs:label "metapodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009877 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0010543 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0009878 ], _:genid151047 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0009877 ] ) ] . obo:UBERON_0010547 obo:IAO_0000115 "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 1 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002040", "EMAPA:17725" ; oboInOwl:hasExactSynonym "hind limb digit 1 metatarsal pre-cartilage condensation", "pedal digit I metatarsal pre-cartilage condensation", "toe 1 metatarsal pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 1 metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010547" ; a owl:Class ; rdfs:label "pedal digit 1 metatarsal pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015037 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010548 obo:IAO_0000115 "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 2 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002045", "EMAPA:17727" ; oboInOwl:hasExactSynonym "hind limb digit 2 metatarsal pre-cartilage condensation", "pedal digit II metatarsal pre-cartilage condensation", "toe 2 metatarsal pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 2 metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010548" ; a owl:Class ; rdfs:label "pedal digit 2 metatarsal pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015038 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010549 obo:IAO_0000115 "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 3 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002050", "EMAPA:17729" ; oboInOwl:hasExactSynonym "hind limb digit 3 metatarsal pre-cartilage condensation", "pedal digit III metatarsal pre-cartilage condensation", "toe 3 metatarsal pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 3 metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010549" ; a owl:Class ; rdfs:label "pedal digit 3 metatarsal pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015039 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010550 obo:IAO_0000115 "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 4 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002055", "EMAPA:17731" ; oboInOwl:hasExactSynonym "hind limb digit 4 metatarsal pre-cartilage condensation", "pedal digit IV metatarsal pre-cartilage condensation", "toe 4 metatarsal pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 4 metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010550" ; a owl:Class ; rdfs:label "pedal digit 4 metatarsal pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015040 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010551 obo:IAO_0000115 "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 5 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002060", "EMAPA:17733" ; oboInOwl:hasExactSynonym "hind limb digit 5 metatarsal pre-cartilage condensation", "pedal digit V metatarsal pre-cartilage condensation", "toe 5 metatarsal pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 5 metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010551" ; a owl:Class ; rdfs:label "pedal digit 5 metatarsal pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015041 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010557 obo:IAO_0000115 "A pedal digit metatarsal cartilage condensation that is part of a pedal digit 1 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18106" ; oboInOwl:hasExactSynonym "hind limb digit 1 metatarsal cartilage condensation", "pedal digit I metatarsal cartilage element", "toe 1 metatarsal cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 1 metatarsal cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010557" ; a owl:Class ; rdfs:label "pedal digit 1 metatarsal cartilage element" ; rdfs:subClassOf _:genid149115 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015037 _:genid149113 ) ] . obo:UBERON_0010558 obo:IAO_0000115 "A pedal digit metatarsal cartilage element that is part of a pedal digit 2 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18111" ; oboInOwl:hasExactSynonym "hind limb digit 2 metatarsal cartilage condensation", "pedal digit II metatarsal cartilage element", "toe 2 metatarsal cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 2 metatarsal cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010558" ; a owl:Class ; rdfs:label "pedal digit 2 metatarsal cartilage element" ; rdfs:subClassOf _:genid149124 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015038 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010559 obo:IAO_0000115 "A pedal digit metatarsal cartilage element that is part of a pedal digit 3 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18116" ; oboInOwl:hasExactSynonym "hind limb digit 3 metatarsal cartilage condensation", "pedal digit III metatarsal cartilage element", "toe 3 metatarsal cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 3 metatarsal cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010559" ; a owl:Class ; rdfs:label "pedal digit 3 metatarsal cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010549 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015039 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010560 obo:IAO_0000115 "A pedal digit metatarsal cartilage element that is part of a pedal digit 4 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18121" ; oboInOwl:hasExactSynonym "hind limb digit 4 metatarsal cartilage condensation", "pedal digit IV metatarsal cartilage element", "toe 4 metatarsal cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 4 metatarsal cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010560" ; a owl:Class ; rdfs:label "pedal digit 4 metatarsal cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010550 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015040 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010561 obo:IAO_0000115 "A pedal digit metatarsal cartilage element that is part of a pedal digit 5 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18126" ; oboInOwl:hasExactSynonym "hind limb digit 5 metatarsal cartilage element", "pedal digit V metatarsal cartilage element", "toe 5 metatarsal cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 5 metatarsal cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010561" ; a owl:Class ; rdfs:label "pedal digit 5 metatarsal cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010551 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015041 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010562 obo:IAO_0000115 "Mesenchyme that is part of a developing pedal digit 1." ; oboInOwl:hasDbXref "EHDAA2:0002039", "EMAPA:17462" ; oboInOwl:hasExactSynonym "hind limb digit 1 mesenchyme", "pedal digit I mesenchyme" ; oboInOwl:hasNarrowSynonym "foot digit 1 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010562" ; a owl:Class ; rdfs:label "pedal digit 1 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0010564 obo:IAO_0000115 "Mesenchyme that is part of a developing manual digit 1." ; oboInOwl:hasDbXref "EHDAA2:0000513", "EMAPA:17431" ; oboInOwl:hasExactSynonym "fore limb digit 1 mesenchyme", "manual digit I mesenchyme" ; oboInOwl:hasNarrowSynonym "hand digit 1 mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010564" ; a owl:Class ; rdfs:label "manual digit 1 mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0010565 obo:IAO_0000115 "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 1 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000515", "EMAPA:17714" ; oboInOwl:hasExactSynonym "finger 1 metacarpus pre-cartilage condensation", "fore limb digit 1 metacarpus pre-cartilage condensation", "manual digit I metacarpus pre-cartilage condensation", "metacarpal 1 pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 1 metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010565" ; a owl:Class ; rdfs:label "manual digit 1 metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149173 ] . obo:UBERON_0010566 obo:IAO_0000115 "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 2 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000521", "EMAPA:17716" ; oboInOwl:hasExactSynonym "finger 2 metacarpus pre-cartilage condensation", "fore limb digit 2 metacarpus pre-cartilage condensation", "manual digit II metacarpus pre-cartilage condensation", "metacarpal 2 pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 2 metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010566" ; a owl:Class ; rdfs:label "manual digit 2 metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015044 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010567 obo:IAO_0000115 "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 3 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000527", "EMAPA:17718" ; oboInOwl:hasExactSynonym "finger 3 metacarpus pre-cartilage condensation", "fore limb digit 3 metacarpus pre-cartilage condensation", "manual digit III metacarpus pre-cartilage condensation", "metacarpal 3 pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 3 metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010567" ; a owl:Class ; rdfs:label "manual digit 3 metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015045 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010568 obo:IAO_0000115 "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 4 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000533", "EMAPA:17720" ; oboInOwl:hasExactSynonym "finger 4 metacarpus pre-cartilage condensation", "fore limb digit 4 metacarpus pre-cartilage condensation", "manual digit IV metacarpus pre-cartilage condensation", "metacarpal 4 pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 4 metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010568" ; a owl:Class ; rdfs:label "manual digit 4 metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015046 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010569 obo:IAO_0000115 "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 5 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000539", "EMAPA:17722" ; oboInOwl:hasExactSynonym "finger 5 metacarpus pre-cartilage condensation", "fore limb digit 5 metacarpus pre-cartilage condensation", "manual digit V metacarpus pre-cartilage condensation", "metacarpal 5 pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 5 metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010569" ; a owl:Class ; rdfs:label "manual digit 5 metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015047 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010570 obo:IAO_0000115 "A manual digit metacarpus cartilage element that is part of a manual digit 1 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000514", "EMAPA:18065" ; oboInOwl:hasExactSynonym "finger 1 metacarpus cartilage element", "fore limb digit 1 metacarpus cartilage element", "manual digit I metacarpus cartilage element", "metacarpus 1 cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 1 metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010570" ; a owl:Class ; rdfs:label "manual digit 1 metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010565 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015043 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010571 obo:IAO_0000115 "A manual digit metacarpus cartilage element that is part of a manual digit 2 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000520", "EMAPA:18070" ; oboInOwl:hasExactSynonym "finger 2 metacarpus cartilage element", "fore limb digit 2 metacarpus cartilage element", "manual digit II metacarpus cartilage element", "metacarpus 2 cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 2 metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010571" ; a owl:Class ; rdfs:label "manual digit 2 metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010566 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015044 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010572 obo:IAO_0000115 "A manual digit metacarpus cartilage element that is part of a manual digit 3 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000526", "EMAPA:18075" ; oboInOwl:hasExactSynonym "finger 3 metacarpus cartilage element", "fore limb digit 3 metacarpus cartilage element", "manual digit III metacarpus cartilage element", "metacarpus 3 cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 3 metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010572" ; a owl:Class ; rdfs:label "manual digit 3 metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010567 ] ; owl:equivalentClass _:genid149237 . obo:UBERON_0010573 obo:IAO_0000115 "A manual digit metacarpus cartilage element that is part of a manual digit 4 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000532", "EMAPA:18080" ; oboInOwl:hasExactSynonym "finger 4 metacarpus cartilage condensation", "fore limb digit 4 metacarpus cartilage element", "manual digit IV metacarpus cartilage element", "metacarpus 4 cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 4 metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010573" ; a owl:Class ; rdfs:label "manual digit 4 metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010568 ] ; owl:equivalentClass _:genid149247 . obo:UBERON_0010574 obo:IAO_0000115 "A manual digit metacarpus cartilage element that is part of a manual digit 5 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000538", "EMAPA:18085" ; oboInOwl:hasExactSynonym "finger 5 metacarpus cartilage condensation", "fore limb digit 5 metacarpus cartilage element", "manual digit V metacarpus cartilage element", "metacarpus 5 cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 5 metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010574" ; a owl:Class ; rdfs:label "manual digit 5 metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010569 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015047 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010575 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit 1 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000516", "EMAPA:17715" ; oboInOwl:hasExactSynonym "fore limb digit 1 phalanx pre-cartilage condensation", "manual digit I phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 1 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010575" ; a owl:Class ; rdfs:label "manual digit 1 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015025 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010576 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit 2 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000522", "EMAPA:17717" ; oboInOwl:hasExactSynonym "fore limb digit 2 phalanx pre-cartilage condensation", "manual digit II phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 2 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010576" ; a owl:Class ; rdfs:label "manual digit 2 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015026 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010577 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit 3 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000528", "EMAPA:17719" ; oboInOwl:hasExactSynonym "fore limb digit 3 phalanx pre-cartilage condensation", "manual digit III phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 3 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010577" ; a owl:Class ; rdfs:label "manual digit 3 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149284 ] . obo:UBERON_0010578 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit 4 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000534", "EMAPA:17721" ; oboInOwl:hasExactSynonym "fore limb digit 4 phalanx pre-cartilage condensation", "manual digit IV phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 4 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010578" ; a owl:Class ; rdfs:label "manual digit 4 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015028 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010579 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit 5 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0000540", "EMAPA:17723" ; oboInOwl:hasExactSynonym "fore limb digit 5 phalanx pre-cartilage condensation", "manual digit V phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit 5 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010579" ; a owl:Class ; rdfs:label "manual digit 5 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015029 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010580 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit 1 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002041", "EMAPA:17726" ; oboInOwl:hasExactSynonym "hind limb digit 1 phalanx pre-cartilage condensation", "pedal digit I phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 1 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010580" ; a owl:Class ; rdfs:label "pedal digit 1 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015031 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010581 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit 2 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002046", "EMAPA:17728" ; oboInOwl:hasExactSynonym "hind limb digit 2 phalanx pre-cartilage condensation", "pedal digit II phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 2 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010581" ; a owl:Class ; rdfs:label "pedal digit 2 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015032 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010582 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit 3 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002051", "EMAPA:17730" ; oboInOwl:hasExactSynonym "hind limb digit 3 phalanx pre-cartilage condensation", "pedal digit III phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 3 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010582" ; a owl:Class ; rdfs:label "pedal digit 3 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015033 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010583 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit 4 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002056", "EMAPA:17732" ; oboInOwl:hasExactSynonym "hind limb digit 4 phalanx pre-cartilage condensation", "pedal digit IV phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 4 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010583" ; a owl:Class ; rdfs:label "pedal digit 4 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015034 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010584 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit 5 mesenchyme." ; oboInOwl:hasDbXref "EHDAA2:0002061", "EMAPA:17734" ; oboInOwl:hasExactSynonym "hind limb digit 5 phalanx pre-cartilage condensation", "pedal digit V phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit 5 phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010584" ; a owl:Class ; rdfs:label "pedal digit 5 phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015035 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010585 obo:IAO_0000115 "A pre-cartilage condensation that is part of a pedal digit mesenchyme." ; oboInOwl:hasDbXref "EMAPA:32950", "VHOG:0000952" ; oboInOwl:hasExactSynonym "foot phalanx pre-cartilage condensation", "hind limb digit phalanx pre-cartilage condensation", "hindlimb phalanx pre-cartilage condensation", "pes phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010585" ; a owl:Class ; rdfs:label "pedal digit phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015030 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010586 obo:IAO_0000115 "A pre-cartilage condensation that is part of a manual digit mesenchyme." ; oboInOwl:hasDbXref "EMAPA:32639", "VHOG:0000954" ; oboInOwl:hasExactSynonym "fore limb digit phalanx pre-cartilage condensation", "forelimb phalanx pre-cartilage condensation", "hand phalanx pre-cartilage condensation", "manus phalanx pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit phalanx pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010586" ; a owl:Class ; rdfs:label "manual digit phalanx pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015024 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010675 obo:IAO_0000115 "A cartilage element that is part of a manual digit 1 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18066" ; oboInOwl:hasExactSynonym "fore limb digit 1 phalanx cartilage condensation", "manual digit I phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 1 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010675" ; a owl:Class ; rdfs:label "manual digit 1 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010575 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015025 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010676 obo:IAO_0000115 "A cartilage element that is part of a manual digit 2 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18071" ; oboInOwl:hasExactSynonym "fore limb digit 2 phalanx cartilage condensation", "manual digit II phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 2 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010676" ; a owl:Class ; rdfs:label "manual digit 2 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015026 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010677 obo:IAO_0000115 "A cartilage element that is part of a manual digit 3 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18076" ; oboInOwl:hasExactSynonym "fore limb digit 3 phalanx cartilage condensation", "manual digit III phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 3 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010677" ; a owl:Class ; rdfs:label "manual digit 3 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010577 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015027 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010678 obo:IAO_0000115 "A cartilage element that is part of a manual digit 4 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18081" ; oboInOwl:hasExactSynonym "fore limb digit 4 phalanx cartilage condensation", "manual digit IV phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 4 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010678" ; a owl:Class ; rdfs:label "manual digit 4 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010578 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149391 ] . obo:UBERON_0010679 obo:IAO_0000115 "A cartilage element that is part of a manual digit 5 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18086" ; oboInOwl:hasExactSynonym "fore limb digit 5 phalanx cartilage condensation", "manual digit V phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit 5 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010679" ; a owl:Class ; rdfs:label "manual digit 5 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010579 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015029 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010680 obo:IAO_0000115 "A cartilage element that is part of a pedal digit 1 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18107" ; oboInOwl:hasExactSynonym "hind limb digit 1 phalanx cartilage condensation", "pedal digit I phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 1 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010680" ; a owl:Class ; rdfs:label "pedal digit 1 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010580 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149409 ] . obo:UBERON_0010681 obo:IAO_0000115 "A cartilage element that is part of a pedal digit 2 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18112" ; oboInOwl:hasExactSynonym "hind limb digit 2 phalanx cartilage condensation", "pedal digit II phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 2 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010681" ; a owl:Class ; rdfs:label "pedal digit 2 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010581 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015032 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010682 obo:IAO_0000115 "A cartilage element that is part of a pedal digit 3 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18117" ; oboInOwl:hasExactSynonym "hind limb digit 3 phalanx cartilage condensation", "pedal digit III phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 3 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010682" ; a owl:Class ; rdfs:label "pedal digit 3 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010582 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015033 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010683 obo:IAO_0000115 "A cartilage element that is part of a pedal digit 4 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18122" ; oboInOwl:hasExactSynonym "hind limb digit 4 phalanx cartilage condensation", "pedal digit IV phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 4 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010683" ; a owl:Class ; rdfs:label "pedal digit 4 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010583 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015034 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010684 obo:IAO_0000115 "A cartilage element that is part of a pedal digit 5 mesenchyme." ; oboInOwl:hasDbXref "EMAPA:18127" ; oboInOwl:hasExactSynonym "hind limb digit 5 phalanx cartilage condensation", "pedal digit V phalanx cartilage element" ; oboInOwl:hasNarrowSynonym "foot digit 5 phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010684" ; a owl:Class ; rdfs:label "pedal digit 5 phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010584 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015035 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010685 obo:IAO_0000115 "A cartilage element that is part of a pedal digit mesenchyme." ; oboInOwl:hasDbXref "EMAPA:32948" ; oboInOwl:hasExactSynonym "hind limb digit phalanx cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit phalanx cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010685" ; a owl:Class ; rdfs:label "pedal digit phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010585 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015030 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010686 obo:IAO_0000115 "A cartilage element that is part of a manual digit mesenchyme." ; oboInOwl:hasDbXref "EMAPA:32658" ; oboInOwl:hasExactSynonym "fore limb digit phalanx cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit phalanx cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010686" ; a owl:Class ; rdfs:label "manual digit phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010586 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015024 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010687 oboInOwl:hasDbXref "EMAPA:32956", "EMAPA:35568", "VHOG:0000948" ; oboInOwl:hasExactSynonym "hind limb digit metatarsal pre-cartilage condensation", "metatarsal bone pre-cartilage condensation", "metatarsus pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit metatarsal pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsal pre-cartilage condensation" ; oboInOwl:id "UBERON:0010687" ; a owl:Class ; rdfs:label "pedal digit metatarsal pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010688 obo:IAO_0000115 "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified]." ; oboInOwl:hasDbXref "FMA:71337", "VSAO:0005029", "Wikipedia:Phalanges_of_the_hand" ; oboInOwl:hasExactSynonym "all phalanges in forelimb autopod", "anterior acropodium skeleton", "fore acropodium skeleton", "hand digit skeleton", "manual digit skeleton", "manual phalanges", "phalanges of hand", "phalanges of manus", "set of manual phalanges", "set of phalanges of hand", "set of phalanges of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior acropodium" ; oboInOwl:id "UBERON:0010688" ; a owl:Class ; rdfs:label "skeleton of manual acropodium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0010544 ], _:genid151474 ; owl:disjointWith obo:UBERON_0010696 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010543 _:genid149479 ) ] . obo:UBERON_0010690 obo:IAO_0000115 "An epithelium that is part of a manual digit 1." ; oboInOwl:hasDbXref "EHDAA2:0000512", "EMAPA:17430" ; oboInOwl:hasExactSynonym "fore limb digit 1 epithelium", "manual digit I epithelium" ; oboInOwl:hasNarrowSynonym "hand digit 1 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010690" ; a owl:Class ; rdfs:label "manual digit 1 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ] . obo:UBERON_0010693 obo:IAO_0000115 "An epithelium that is part of a pedal digit 1." ; oboInOwl:hasDbXref "EHDAA2:0002038", "EMAPA:17461" ; oboInOwl:hasExactSynonym "hind limb digit 1 epithelium", "pedal digit I epithelium" ; oboInOwl:hasNarrowSynonym "foot digit 1 epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010693" ; a owl:Class ; rdfs:label "pedal digit 1 epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0010695 obo:IAO_0000115 "Mesenchyme of the carpal region that contributes to the tarsal skeleton." ; oboInOwl:hasDbXref "EMAPA:18502" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010695" ; a owl:Class ; rdfs:label "mesenchyme of tarsal region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ] . obo:UBERON_0010696 obo:IAO_0000115 "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm]." ; oboInOwl:hasDbXref "FMA:78512", "VSAO:0005030", "Wikipedia:Phalanges_of_the_foot" ; oboInOwl:hasExactSynonym "all phalanges in hindlimb autopod", "foot digit skeleton", "hind acropodium skeleton", "pedal phalanges", "phalanges of foot", "phalanges of pes", "posterior acropodium skeleton", "set of pedal phalanges", "set of phalanges of foot", "set of phalanges of pes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior acropodium" ; oboInOwl:id "UBERON:0010696" ; a owl:Class ; rdfs:label "skeleton of pedal acropodium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0010545 ], _:genid151508 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149511 ] . obo:UBERON_0010697 obo:IAO_0000116 "EMAPA represents the specific child classes as being part of the digit mesenchyme - we follow this although for the fully formed structure we represent the metatarsals as adjoining rather than being part of the digit skeleton" ; oboInOwl:hasDbXref "EMAPA:32951" ; oboInOwl:hasExactSynonym "hind limb digit metatarsal cartilage condensation" ; oboInOwl:hasNarrowSynonym "foot digit metatarsal cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsal cartilage condensation" ; oboInOwl:id "UBERON:0010697" ; a owl:Class ; rdfs:label "pedal digit metatarsal cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010687 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149522 ] . obo:UBERON_0010698 oboInOwl:hasDbXref "EMAPA:32850", "VHOG:0000953" ; oboInOwl:hasExactSynonym "fore limb digit metacarpus pre-cartilage condensation", "metacarpal bone pre-cartilage condensation", "metacarpal pre-cartilage condensation", "metacarpus pre-cartilage condensation" ; oboInOwl:hasNarrowSynonym "hand digit metacarpus pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010698" ; a owl:Class ; rdfs:label "manual digit metacarpus pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010699 oboInOwl:hasDbXref "EMAPA:32849" ; oboInOwl:hasExactSynonym "finger metacarpus cartilage element", "fore limb digit metacarpus cartilage element", "metacarpal cartilage element", "metacarpus cartilage element" ; oboInOwl:hasNarrowSynonym "hand digit metacarpus cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metacarpal cartilage condensation" ; oboInOwl:id "UBERON:0010699" ; a owl:Class ; rdfs:label "manual digit metacarpus cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010698 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010700 oboInOwl:hasDbXref "EMAPA:32720" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010700" ; a owl:Class ; rdfs:label "phalanx pre-cartilage condensation" ; rdfs:subClassOf _:genid151544 ; owl:equivalentClass _:genid149545 . obo:UBERON_0010701 oboInOwl:hasDbXref "EMAPA:32721" ; oboInOwl:hasExactSynonym "phalanx cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010701" ; a owl:Class ; rdfs:label "phalanx cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010700 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010702 obo:IAO_0000115 "Mesenchyme of the digit region." ; oboInOwl:hasDbXref "EMAPA:32719", "NCIT:C34141", "UMLS:C1511959" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digital ray" ; oboInOwl:id "UBERON:0010702" ; a owl:Class ; rdfs:label "digit mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] . obo:UBERON_0010703 obo:IAO_0000115 "The collection of all skeletal elements in an forelimb zeugopod region." ; obo:IAO_0000116 "adding proxinally_connected_to humerus causes inconsistencies - requires investigation" ; obo:UBPROP_0000001 "Segment of the forearm corresponding to the radius and ulna.[AAO]" ; oboInOwl:hasDbXref "AAO:0000200", "FMA:71199", "VSAO:0005011" ; oboInOwl:hasExactSynonym "antebrachial skeleton", "antebrachium skeleton", "anterior zeugopodium skeleton", "fore epipodium skeleton", "forearm skeleton", "skeleton of forearm" ; oboInOwl:hasNarrowSynonym "wing zeugopod skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior zeugopodium", "fore epipodium", "forelimb epipodium", "forelimb epipodium skeleton", "mesomere 2 of pectoral appendage", "radius and ulna" ; oboInOwl:id "UBERON:0010703" ; a owl:Class ; rdfs:label "forelimb zeugopod skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386 ] ; owl:disjointWith obo:UBERON_0010720 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002386 ] ) ] . obo:UBERON_0010707 obo:IAO_0000115 "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." ; obo:IAO_0000116 "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" ; obo:UBPROP_0000001 "Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO]" ; obo:UBPROP_0000005 "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" ; obo:UBPROP_0000012 "note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region)" ; dcterms:contributor ; oboInOwl:creation_date "2012-04-23T10:46:51Z" ; oboInOwl:hasDbXref "EMAPA:37858", "FMA:7182", "VSAO:0000214" ; oboInOwl:hasExactSynonym "appendage complex", "appendage-girdle complex", "appendage/girdle complex", "girdle plus limb or fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "limb" ; oboInOwl:id "UBERON:0010707" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "appendage girdle complex" ; rdfs:subClassOf obo:UBERON_0000475, _:genid149580, [ a owl:Restriction ; owl:onProperty obo:RO_0002328 ; owl:someValuesFrom obo:GO_0040011 ] . obo:UBERON_0010708 obo:IAO_0000115 "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." ; obo:UBPROP_0000001 "Appendage girdle complex that when present, encompasses the pectoral appendage and half of the pectoral girdle.[VSAO]" ; obo:UBPROP_0000012 "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region)" ; oboInOwl:hasDbXref "EMAPA:37860", "FMA:7183", "SCTID:110716002", "VSAO:0000213" ; oboInOwl:hasExactSynonym "pectoral appendage/girdle complex", "pectoral girdle plus anterior limb or fin", "pectoral girdle plus pectoral limb or fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "upper limb", "upper limb and pectoral girdle", "upper limb and shoulder" ; oboInOwl:id "UBERON:0010708" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pectoral complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0012475 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010707 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_0010709 obo:IAO_0000115 "Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle." ; obo:RO_0002171 obo:UBERON_0010708 ; obo:UBPROP_0000001 "Appendage girdle complex that when present, encompasses the pelvic appendage and the pelvic girdle.[VSAO]" ; obo:UBPROP_0000012 "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region). Note the MA class 'hindlimb' may also belong here" ; oboInOwl:hasDbXref "EMAPA:37863", "FMA:7184", "SCTID:416631005", "VSAO:0000215" ; oboInOwl:hasExactSynonym "pelvic appendage/girdle complex", "pelvic girdle plus pelvic limb or fin", "pelvic girdle plus posterior limb or fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower limb", "lower limb and pelvic girdle", "lower limb and pelvis" ; oboInOwl:id "UBERON:0010709" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pelvic complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0012476 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010707 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001271 ] ) ] . obo:UBERON_0010712 obo:IAO_0000115 "Skeletal subdivision that is a segment of the limb skeleton." ; obo:IAO_0000116 "note the distinction between this and skeleton of limb" ; oboInOwl:hasDbXref "VSAO:0005018" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010712" ; a owl:Class ; rdfs:label "limb skeleton subdivision" ; rdfs:subClassOf _:genid151622 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0010714 obo:IAO_0000115 "An iliac endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0000808", "EMAPA:18347", "VHOG:0001126" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "iliac cartilage condensation" ; oboInOwl:id "UBERON:0010714" ; a owl:Class ; rdfs:label "iliac cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, _:genid151630, _:genid151632 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015054 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010718 obo:IAO_0000115 "A pubic endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001573", "EMAPA:26928" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pubic cartilage condensation" ; oboInOwl:id "UBERON:0010718" ; a owl:Class ; rdfs:label "pubic cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, _:genid151641, _:genid151643 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015055 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010719 obo:IAO_0000115 "The subdivision of the skeleton of either the pectoral or pelvic girdle." ; obo:UBPROP_0000001 "Skeletal subdivision that is part of the appendage girdle region.[VSAO]" ; obo:UBPROP_0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: part_of subdivision of skeleton (UBERON:0010912)[VSAO]", "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: proximally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" ; oboInOwl:hasDbXref "AAO:0010686", "VSAO:0000302" ; oboInOwl:hasExactSynonym "skeleton of girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010719" ; a owl:Class ; rdfs:label "girdle skeleton" ; rdfs:subClassOf _:genid149650, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007823 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0002090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0007823 ] ) ] . obo:UBERON_0010720 obo:IAO_0000115 "Subdivision of skeleton consisting of all skeletal elements in an hindlimb zeugopod region. Typically consists of the tibia and the fibula." ; obo:UBPROP_0000001 "Segment of the leg corresponding to the tibia and fibula.[AAO]" ; oboInOwl:hasDbXref "AAO:0000216", "VSAO:0005014" ; oboInOwl:hasExactSynonym "crural skeleton", "crus skeleton", "hindlimb zygopod skeleton", "posterior zeugopodium skeleton", "skeleton cruris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hind epipodium", "hindlimb epipodium", "mesomere 2 of pelvic appendage", "posterior zeugopodium" ; oboInOwl:id "UBERON:0010720" ; a owl:Class ; rdfs:label "hindlimb zeugopod skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0000981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 _:genid149659 ) ] . obo:UBERON_0010721 obo:IAO_0000115 "There are three cuneiform bones in the human foot: the medial cuneiform the intermediate cuneiform also known as the middle the lateral cuneiform. They are located between the navicular bone and the first, second and third metatarsal bones and are medial to the cuboid bone[WP, unvetted, human specific]." ; obo:UBPROP_0000001 "Series of elements that articulate with the metatarsals.[AAO]" ; oboInOwl:hasDbXref "AAO:0000914", "FMA:24517", "NCIT:C32416", "SCTID:182102002", "UMLS:C1511560", "Wikipedia:Cuneiform_(anatomy)" ; oboInOwl:hasExactSynonym "cuneiform bone", "distal tarsal", "distal tarsal bone", "os cuneiform", "os cuneiforme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cuneiform" ; oboInOwl:id "UBERON:0010721" ; a owl:Class ; rdfs:label "distal tarsal bone" ; rdfs:subClassOf obo:UBERON_0002513, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015100 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0001448 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray268.png"^^xsd:anyURI . obo:UBERON_0010728 obo:IAO_0000115 "An orbitosphenoid endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0003449" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010728" ; a owl:Class ; rdfs:label "sphenoid lesser wing pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, _:genid151691, _:genid151693 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149686 ] . obo:UBERON_0010737 obo:IAO_0000115 "Endochondral tarsal bone articulating with centralia and metatarsal 4." ; obo:IAO_0000116 "We need to restrict the logical definition such that it is *only* connecting to metatarsal 4" ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metatarsal IV. It may be absent in some taxa.[AAO]" ; obo:UBPROP_0000013 "NominaAnatomicaVeterinaria uses os cuboideum as an official synonym for distal tarsal IV, but some sources also use this as the label for the human cuboid bone which is regarded to be formed from tarsals IV and V. We therefore decline to use exact syns in either case." ; oboInOwl:hasBroadSynonym "distal tarsal 4", "tarsal 4" ; oboInOwl:hasDbXref "AAO:0000932", "VSAO:0005055" ; oboInOwl:hasExactSynonym "os tarsale IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cuboideum", "os cuboideum" ; oboInOwl:id "UBERON:0010737" ; a owl:Class ; rdfs:label "distal tarsal bone 4" ; rdfs:subClassOf obo:UBERON_0010721, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015112 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003653 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015111 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0010738 obo:IAO_0000115 "Endochondral tarsal bone articulating with centralia and metatarsal 5." ; obo:UBPROP_0000001 "Small element that articulates anteriorly with metatarsal V. It may be absent in some taxa.[AAO]" ; oboInOwl:hasDbXref "AAO:0000933", "VSAO:0005056" ; oboInOwl:hasExactSynonym "distal tarsal 5", "tarsal 5" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cuboideum" ; oboInOwl:id "UBERON:0010738" ; a owl:Class ; rdfs:comment "We need to restrict the logical definition such that it is *only* connecting to metatarsal 5" ; rdfs:label "distal tarsal bone 5" ; rdfs:subClassOf obo:UBERON_0010721, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015115 ], [ a owl:Restriction ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0003654 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001451 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015114 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0010740 obo:IAO_0000115 "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." ; oboInOwl:hasDbXref "EMAPA:35494", "MA:0000688" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of extended limb/fin region", "limb bone" ; oboInOwl:id "UBERON:0010740" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone of appendage girdle complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002091 ], _:genid151728 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010707 ] ) ] . obo:UBERON_0010741 obo:IAO_0000115 "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." ; obo:IAO_0000116 "considering adding pectoral and pelvic complex skeleton classes" ; obo:UBPROP_0000012 "note that the MA class includes girdle parts so it belongs here;" ; oboInOwl:hasDbXref "EMAPA:32623", "EMAPA:35933", "MA:0000612" ; oboInOwl:hasNarrowSynonym "wing bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bone of forelimb or pectoral fin or pectoral girdle", "forelimb bone" ; oboInOwl:id "UBERON:0010741" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone of pectoral complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid149731 ] . obo:UBERON_0010742 obo:IAO_0000115 "A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle." ; obo:UBPROP_0000012 "the MA class called 'hindlimb bone' belongs here, as it includes bones in the pelvic girdle" ; oboInOwl:hasDbXref "EMAPA:32633", "EMAPA:35934", "MA:0000660" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindlimb bone" ; oboInOwl:id "UBERON:0010742" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone of pelvic complex" ; rdfs:subClassOf obo:UBERON_0010740, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_0010743 obo:IAO_0000115 "The collection of all meningeal layers that line a central nervous system." ; obo:UBPROP_0000007 "meningeal" ; obo:UBPROP_0000008 "In some primitive organisms, the meningeal cluster includes only the primitive meninx" ; oboInOwl:hasDbXref "EHDAA2:0004661", "EMAPA:32660", "FMA:231572", "NCIT:C12349", "SCTID:362879001", "UMLS:C0228116", "Wikipedia:Meninges", "neuronames:1465" ; oboInOwl:hasExactSynonym "cerebral meninges", "cluster of meninges", "meninges" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010743" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "meningeal cluster" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034925 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0002360 ] ) ] . obo:UBERON_0010744 obo:IAO_0000115 "A sacral vertebra endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EHDAA2:0001774", "EMAPA:17677" ; oboInOwl:hasExactSynonym "sacral vertebral pre-cartilage condensation group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010744" ; a owl:Class ; rdfs:label "sacral vertebra pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015010 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010745 obo:IAO_0000115 "A sacral vertebra endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001773", "EMAPA:18009" ; oboInOwl:hasExactSynonym "sacral vertebral cartilage condensation", "sacral vertebral cartilage condensation group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010745" ; a owl:Class ; rdfs:label "sacral vertebra cartilage element" ; rdfs:subClassOf _:genid151773 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015010 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010746 obo:IAO_0000115 "The extension of the ilium above the level of the acetabulum. Attachment site for both hindlimb and caudal musculature. Medially is the site of attachment of the sacral ribs, where these exist[PHENOSCAPE:ad]." ; obo:UBPROP_0000008 "Often dorsally expanded in amniotes" ; oboInOwl:hasDbXref "FMA:42826", "SCTID:182024000", "Wikipedia:Wing_of_ilium" ; oboInOwl:hasExactSynonym "a. ossis ilii", "ala of ilium", "ala ossis ilii", "ilium ala", "wing of ilium", "wing of the ilium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010746" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "iliac blade" ; rdfs:subClassOf obo:UBERON_0005913, _:genid149772 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray235.png"^^xsd:anyURI . obo:UBERON_0010747 obo:IAO_0000115 "The body of ilium enters into the formation of the acetabulum, of which it forms rather less than two-fifths. Its external surface is partly articular, partly non-articular; the articular segment forms part of the lunate surface of the acetabulum, the non-articular portion contributes to the acetabular fossa. The internal surface of the body is part of the wall of the lesser pelvis and gives origin to some fibers of the Obturator internus. Below, it is continuous with the pelvic surfaces of the ischium and pubis, only a faint line indicating the place of union." ; oboInOwl:hasDbXref "FMA:42825", "SCTID:292524005", "Wikipedia:Body_of_ilium" ; oboInOwl:hasExactSynonym "ilium body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corpus ossis ilii" ; oboInOwl:id "UBERON:0010747" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "body of ilium" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001273 ] . obo:UBERON_0010748 obo:IAO_0000115 "A lymphoid follicle that is part of a lymph node." ; oboInOwl:hasDbXref "EMAPA:35527", "MA:0000742" ; oboInOwl:hasExactSynonym "follicle of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010748" ; a owl:Class ; rdfs:label "lymph node follicle" ; rdfs:subClassOf _:genid151795 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000444 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_0010751 oboInOwl:hasDbXref "EHDAA2:0001907", "EHDAA:9536" ; oboInOwl:hasExactSynonym "squamosal bone primordium", "squamosal primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010751" ; a owl:Class ; rdfs:label "squamous part of temporal bone primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 ], _:genid151802 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001695 ] ) ] . obo:UBERON_0010753 obo:IAO_0000115 "A secondary follicle that is located in a lymph node." ; oboInOwl:hasDbXref "EMAPA:35531", "FMA:312352", "MA:0000744" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010753" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "lymph node secondary follicle" ; rdfs:subClassOf obo:UBERON_0010748, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010395 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001745 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_0010754 obo:IAO_0000115 "A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center." ; oboInOwl:hasDbXref "BTO:0003671", "EV:0100051", "MESH:D018858", "NCIT:C13337", "SCTID:64626006", "UMLS:C0282491", "Wikipedia:Germinal_center" ; oboInOwl:hasExactSynonym "central zone of follice", "reaction center of follicle" ; oboInOwl:hasNarrowSynonym "light zone of follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lymhpoid nodule", "nodule" ; oboInOwl:id "UBERON:0010754" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.[GO]" ; rdfs:label "germinal center" ; rdfs:subClassOf obo:UBERON_0001744, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001745 ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg"^^xsd:anyURI . obo:UBERON_0010755 obo:IAO_0000115 "The part of the secondary follicle that surrounds the germinal center." ; obo:IAO_0000116 "consider making terminology consistent amongst subclasses - see https://github.com/obophenotype/uberon/issues/7" ; oboInOwl:hasDbXref "NCIT:C33053", "UMLS:C1512987", "Wikipedia:Mantle_zone" ; oboInOwl:hasExactSynonym "inactive zone of follicle", "peripheral zone of follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "B cell corona", "dark zone of follicle", "mantle zone" ; oboInOwl:id "UBERON:0010755" ; a owl:Class ; rdfs:label "secondary follicle corona" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001744 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001745 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0010754 ] ) ] . obo:UBERON_0010758 obo:IAO_0000115 "A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg." ; oboInOwl:hasDbXref "FBbt:00007018" ; oboInOwl:hasExactSynonym "appendage segment", "appendicular segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010758" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "subdivision of organism along appendicular axis" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ] . obo:UBERON_0010760 obo:IAO_0000115 "The supraglenoid tubercle is a region of the scapula to which the long head of the biceps brachii muscle attaches." ; oboInOwl:hasDbXref "FMA:23263", "Wikipedia:Supraglenoid_tubercle" ; oboInOwl:hasExactSynonym "supraglenoid tuberosity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tuberculum supraglenoidale" ; oboInOwl:id "UBERON:0010760" ; a owl:Class ; rdfs:label "supraglenoid tubercle" ; rdfs:subClassOf obo:UBERON_0005813, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006633 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Gray205_left_scapula_lateral_view.png"^^xsd:anyURI . obo:UBERON_0010801 obo:IAO_0000115 "A calcaneum endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasDbXref "EMAPA:17736" ; oboInOwl:hasExactSynonym "calcaneous pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010801" ; a owl:Class ; rdfs:label "calcaneum pre-cartilage condensation" ; rdfs:subClassOf obo:UBERON_0005866, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015014 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010842 obo:IAO_0000115 "A calcaneum endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EMAPA:18143" ; oboInOwl:hasExactSynonym "calcaneous cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010842" ; a owl:Class ; rdfs:label "calcaneum cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010801 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015014 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010843 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a clavicle." ; obo:UBPROP_0000008 "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." ; oboInOwl:hasDbXref "EMAPA:18342" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010843" ; a owl:Class ; rdfs:label "clavicle cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010844 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005863 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ] . obo:UBERON_0010844 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a clavicle." ; obo:UBPROP_0000008 "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." ; oboInOwl:hasDbXref "EMAPA:18026" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010844" ; a owl:Class ; rdfs:label "clavicle pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ] . obo:UBERON_0010846 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a radius bone." ; obo:IAO_0000116 "still to decide whether this is a distinct pre-cartilage condensation" ; oboInOwl:hasDbXref "EHDAA2:0001586" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010846" ; a owl:Class ; rdfs:label "radius pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ], _:genid151871, _:genid151874 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0010847 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a ulna." ; oboInOwl:hasDbXref "EHDAA2:0002100", "EHDAA:6226" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010847" ; a owl:Class ; rdfs:label "ulna pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ], _:genid151881, _:genid151884 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0010848 obo:IAO_0000115 "A radius-ulna endochondral element that is composed primarily of cartilage tissue." ; obo:UBPROP_0000012 "note that this is not represented as a single unit in EHDAA2" ; oboInOwl:hasDbXref "EMAPA:17711" ; oboInOwl:hasExactSynonym "radio-ulna cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010848" ; a owl:Class ; rdfs:label "radius-ulna cartilage element" ; rdfs:subClassOf obo:UBERON_0005863, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006287 ], _:genid151891 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015002 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010849 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a tibia." ; oboInOwl:hasDbXref "EMAPA:18155" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010849" ; a owl:Class ; rdfs:label "tibia cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010850 ], _:genid151902 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015004 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010850 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a tibia." ; oboInOwl:hasDbXref "EHDAA2:0002036" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010850" ; a owl:Class ; rdfs:label "tibia pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ], _:genid151911 ; owl:equivalentClass _:genid149894 . obo:UBERON_0010851 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a fibula." ; oboInOwl:hasDbXref "EMAPA:18154" ; oboInOwl:hasExactSynonym "fibulal cartilage condensation", "fibular cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibulra cartilage condensation" ; oboInOwl:id "UBERON:0010851" ; a owl:Class ; rdfs:label "fibula cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010852 ], _:genid151920 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015013 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010852 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a fibula." ; oboInOwl:hasDbXref "EHDAA2:0000509", "EHDAA:6196" ; oboInOwl:hasExactSynonym "fibulal pre-cartilage condensation", "fibular pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010852" ; a owl:Class ; rdfs:label "fibula pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], _:genid151932 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0010879 obo:IAO_0000115 "A calcareous tooth that is elongated and protrudes from the mouth." ; obo:UBPROP_0000001 "Elongated, continuously growing front teeth, usually but not always in pairs, that protrude well beyond the mouth of certain mammal species. They are most commonly canines, as with warthogs, pig, and walruses, or, in the case of elephants and narwhals, elongated incisors. In most tusked species both the males and the females have tusks although the males are larger. Tusks are generally curved, though the narwhal's sole tusk is straight and has a helical structure. In the elephant, the tusks were originally second incisors. Continuous growth is enabled by formative tissues in the apical oproperty_value external_definitionof the roots of the teeth" ; oboInOwl:hasDbXref "SCTID:54040005", "Wikipedia:Tusk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010879" ; a owl:Class ; rdfs:label "tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] ) ] . obo:UBERON_0010881 obo:IAO_0000115 "A skeletal element that is part of a limb and composed of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010881" ; a owl:Class ; rdfs:label "limb cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010882 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015061 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010882 obo:IAO_0000115 "A skeletal element that is part of a limb and composed of pre-cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010882" ; a owl:Class ; rdfs:label "limb bone pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015061 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010883 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a forelimb bone." ; oboInOwl:hasDbXref "EMAPA:32626" ; oboInOwl:hasNarrowSynonym "forelimb wing cartilaginous condensation", "wing cartilaginous condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010883" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "forelimb cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010884 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015021 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010884 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a forelimb bone." ; oboInOwl:hasDbXref "EMAPA:32625" ; oboInOwl:hasNarrowSynonym "wing bone pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010884" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "forelimb bone pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015021 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010885 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a hindlimb bone." ; oboInOwl:hasDbXref "EMAPA:32632" ; oboInOwl:hasExactSynonym "hindlimb cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010885" ; a owl:Class ; rdfs:label "hindlimb cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010886 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015022 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0010886 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a hindlimb bone." ; oboInOwl:hasDbXref "EMAPA:32638" ; oboInOwl:hasExactSynonym "hindlimb pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010886" ; a owl:Class ; rdfs:label "hindlimb pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015022 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0010887 obo:IAO_0000115 "A small pointed eminence of the external ear, situated in front of the concha, and projecting backward over the meatus." ; obo:UBPROP_0000008 "The tragus is generally believed to play a role in vertical sound localization in bats" ; oboInOwl:hasDbXref "FMA:60998", "NCIT:C33801", "SCTID:362541003", "UMLS:C0229312", "Wikipedia:Tragus_(ear)" ; oboInOwl:hasExactSynonym "tragal part of pinna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010887" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tragus" ; rdfs:subClassOf obo:UBERON_0001444, _:genid151981, _:genid151983 . obo:UBERON_0010890 obo:IAO_0000115 "Muscles of the pelvic girdle, hindlimb or pelvic fin." ; obo:UBPROP_0000001 "Muscles of the pelvic girdle, thigh, leg (crus), and foot (pes).[AAO]" ; oboInOwl:hasDbXref "AAO:0000218", "EMAPA:32634", "FMA:9622", "MA:0000663" ; oboInOwl:hasExactSynonym "pelvic girdle and hind limb muscles" ; oboInOwl:hasNarrowSynonym "pelvic girdle or hind limb muscle", "pelvic girdle or posterior limb muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower limb muscle", "muscle of lower limb", "muscle of pelvic girdle and leg" ; oboInOwl:id "UBERON:0010890" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pelvic complex muscle" ; rdfs:subClassOf _:genid151992 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_0010891 obo:IAO_0000115 "A muscle of a pectoral girdle, pectoral fin or anterior limb." ; obo:IAO_0000116 "the MA class belongs here, based on its current child classes" ; obo:UBPROP_0000001 "Muscles of the pectoral girdle, arm, forearm, and hand (brachium, antebrachium, manus respectively).[AAO]" ; oboInOwl:hasDbXref "AAO:0010687", "EMAPA:32624", "FMA:9621", "MA:0000615" ; oboInOwl:hasExactSynonym "pectoral girdle and fore limb muscles" ; oboInOwl:hasNarrowSynonym "muscle of pectoral girdle and wing", "muscle of upper limb", "upper limb muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle of pectoral girdle and limb" ; oboInOwl:id "UBERON:0010891" ; a owl:Class ; rdfs:label "pectoral complex muscle" ; rdfs:subClassOf _:genid152005 ; owl:equivalentClass _:genid149982 . obo:UBERON_0010893 obo:IAO_0000115 "Am unpaired external naris that lies in the midline of the head." ; oboInOwl:hasAlternativeId "UBERON:0012123" ; oboInOwl:hasExactSynonym "median anterior naris", "median nostril", "nasohypophysial opening" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010893" ; oboInOwl:inSubset core:cyclostome_subset ; a owl:Class ; rdfs:label "median external naris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005928 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0010894 oboInOwl:hasExactSynonym "horny denticle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010894" ; oboInOwl:inSubset core:cyclostome_subset ; a owl:Class ; rdfs:comment "The hagfish's jawless mouth contains two parallel rows of pointed keratinous teeth" ; rdfs:label "keratinous tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003913 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0045095 ] ) ] . obo:UBERON_0010899 obo:IAO_0000115 "Hermaphroditic organism that produces both male and female gametes at the same time." ; oboInOwl:hasDbXref "AAO:0010046", "BILA:0000046", "CARO:0000046", "HAO:0000046", "TADS:0000609" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "serially hermaphroditic organism", "simultaneous hermaphroditic organism" ; oboInOwl:id "UBERON:0010899" ; a owl:Class ; rdfs:label "synchronous hermaphroditic organism" ; rdfs:subClassOf obo:UBERON_0007197 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000473 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0010905 obo:IAO_0000115 "A primordium that develops into a clavicle bone." ; oboInOwl:hasDbXref "EHDAA2:0000254" ; oboInOwl:hasExactSynonym "clavicle primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010905" ; a owl:Class ; rdfs:comment "lateral part derives from a fish dermal bone while the medial part comes from a spur off the manubrium endochondral bone[JB]" ; rdfs:label "clavicle bone primordium" ; rdfs:subClassOf _:genid152038, _:genid152040, _:genid152042 ; owl:equivalentClass _:genid150014 . obo:UBERON_0010911 obo:IAO_0000115 "Skeletal element that is often isolated, small, and variable in composition." ; oboInOwl:hasDbXref "VSAO:0000132", "Wikipedia:Ossicles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010911" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Ossicles are composed of a combination skeletal tissues, including bone, calcified cartilage, hyaline cartilage, etc, and exhibit variable development across species. Ossicles are not necessarily jointed, and examples include the menisci of synovial joints, 'Panda's thumb' (radial sesamoid), cardiac skeletal elements, sclerotic bones, middle ear ossicles, and sesamoids." ; rdfs:label "ossicle" ; rdfs:subClassOf obo:UBERON_0004765 . obo:UBERON_0010912 obo:IAO_0000115 "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." ; obo:UBPROP_0000001 "Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]" ; oboInOwl:hasDbXref "FMA:23879", "SCTID:129140006", "VSAO:0000042" ; oboInOwl:hasExactSynonym "skeletal subdivision" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "subdivision of skeleton (in vivo)" ; oboInOwl:id "UBERON:0010912" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of skeleton" ; rdfs:subClassOf obo:UBERON_0011216, _:genid152048, _:genid152050 . obo:UBERON_0010913 obo:IAO_0000115 "Skeletal element that forms around the notochord and is part of the vertebral column." ; obo:IAO_0000232 "we include a distinct subclass for bony vertebra" ; obo:UBPROP_0000003 "In contrast to lampreys and jawed vertebrates, hagfishes were thought to lack vertebrae. Now, long overlooked vertebral rudiments have been analysed in hagfish, suggesting that vertebrae existed in the last common ancestor of all vertebrates.[well established][VHOG]" ; obo:UBPROP_0000007 "vertebral" ; obo:UBPROP_0000008 "Typically an endochondral element, in salamanders there is an argument that vertebral development is perichondral and not preformed in cartilage" ; oboInOwl:hasAlternativeId "UBERON:0015005" ; oboInOwl:hasBroadSynonym "vertebra skeletal element" ; oboInOwl:hasDbXref "VHOG:0001143", "VSAO:0000184" ; oboInOwl:hasExactSynonym "vertebra element" ; oboInOwl:hasNarrowSynonym "vertebra endochondral element", "vertebral endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010913" ; a owl:Class ; rdfs:label "vertebral element" ; rdfs:subClassOf obo:UBERON_0004765, _:genid152057, _:genid152059 . obo:UBERON_0010929 oboInOwl:hasDbXref "EHDAA2:0001909" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010929" ; a owl:Class ; rdfs:label "stapedius pre-muscle condensation" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152068, _:genid152070 . obo:UBERON_0010932 obo:IAO_0000115 "Cricoarytenoid muscles are muscles that connect the cricoid cartilage and arytenoid cartilage. More specifically, it can refer to: Posterior cricoarytenoid muscle Lateral cricoarytenoid muscle." ; obo:IAO_0000116 "candidate for obsoletion. See https://github.com/obophenotype/uberon/issues/530" ; oboInOwl:hasDbXref "EMAPA:37498", "MA:0002283", "NCIT:C32398", "SCTID:244811003", "UMLS:C0448336", "Wikipedia:Cricoarytenoid_muscle" ; oboInOwl:hasExactSynonym "crico-arytenoid", "cricoarytenoid", "cricoarytenoid muscle", "cricoarytenoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010932" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:label "crico-arytenoid muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/530"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0006328, _:genid152073, _:genid152075, _:genid152077, _:genid152079 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray959.png"^^xsd:anyURI . obo:UBERON_0010933 obo:IAO_0000115 "The orbicularis oris is a superficial facial muscle with fibers that encircle the opening of the oral cavity that attaches to the maxilla, mandible, skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve (CN VII)." ; obo:UBPROP_0000001 "The orbicularis oris is a superficial facial muscle that attaches to the skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve .[FEED]" ; oboInOwl:hasDbXref "FMA:46841", "MFMO:0000058", "SCTID:244749008", "Wikipedia:Orbicularis_oris_muscle" ; oboInOwl:hasExactSynonym "orbicularis oris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "incisivii labii inferioris", "incisivii labii superioris", "musculus orbicularis oris", "nasolabialis muscle", "orbicularis oris" ; oboInOwl:id "UBERON:0010933" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "orbicularis oris muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/473"^^xsd:anyURI ; rdfs:subClassOf _:genid152099, _:genid152101, _:genid152103, _:genid152105 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001577 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000166 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002097 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011386 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/b6/Orbicularis_oris.jpg"^^xsd:anyURI . obo:UBERON_0010935 oboInOwl:hasDbXref "EHDAA2:0002002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010935" ; a owl:Class ; rdfs:label "tensor tympani pre-muscle condensation" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152116, _:genid152118 . obo:UBERON_0010938 oboInOwl:hasBroadSynonym "belly", "venter" ; oboInOwl:hasDbXref "FMA:9719", "SCTID:29823001" ; oboInOwl:hasExactSynonym "belly of muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010938" ; a owl:Class ; rdfs:label "muscle belly" ; rdfs:subClassOf obo:UBERON_0000064, _:genid152120 . obo:UBERON_0010940 obo:IAO_0000115 "Either of the two muscles that comprise the digastric group (anterior or posterior)." ; obo:UBPROP_0000012 "FMA represents this as a muscle belly, but this classification does not work well across mammals (pers. comm., FEED:rd), so we classify this is a distinct muscle organ here." ; oboInOwl:hasDbXref "FMA:46297", "SCTID:360772008" ; oboInOwl:hasNarrowSynonym "belly of digastric", "digastric belly" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "belly of digastric muscle", "digastric", "digastric muscle", "digastricus", "muscle body proper of digastric", "musculus digastricus" ; oboInOwl:id "UBERON:0010940" ; a owl:Class ; rdfs:label "muscle of digastric group" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001562 ] ) ] . obo:UBERON_0010943 obo:IAO_0000115 "The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid (a branch of the third division of the trigeminal nerve), is attached to the mandible and to the hyoid apparatus, and it is superficial to mylohyoid muscle." ; obo:UBPROP_0000001 "The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid and superficial to mylohyoid muscle, and lacks the midline raphe.[FEED]" ; obo:UBPROP_0000008 "absent in orangutans" ; oboInOwl:hasDbXref "EMAPA:37405", "FMA:46302", "SCTID:141804004" ; oboInOwl:hasExactSynonym "anterior belly of digastric", "anterior belly of digastric muscle", "anterior digastric", "anterior digastric muscle", "digastric, anterior", "digastricus anterior", "digastricus anterior belly", "digastricus, venter rostralis", "venter anterior (musculus digastricus)", "venter posterior musculus digastrici anterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010943" ; oboInOwl:inSubset core:feed_aligned, core:human_reference_atlas ; a owl:Class ; rdfs:label "anterior digastric muscle" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/538"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0010940, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ], _:genid150107, _:genid152146 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018544 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000108 ; owl:someValuesFrom obo:UBERON_0001564 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001684 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001685 ] ) ] . obo:UBERON_0010946 obo:IAO_0000115 "The occipitofrontalis or epicranius is a muscle which covers parts of the skull. It consists of two parts or bellies: The occipital belly, near the occipital bone, and the frontal belly, near the frontal bone." ; obo:UBPROP_0000012 "A zone of muscle in FMA" ; oboInOwl:hasDbXref "FMA:9624", "NCIT:C33198", "SCTID:361811007", "UMLS:C1518531", "Wikipedia:Occipitofrontalis_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epicranius", "musculus occipitofrontalis", "occipito-frontalis", "occipitofrontalis" ; oboInOwl:id "UBERON:0010946" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "occipitofrontalis muscle" ; rdfs:subClassOf obo:UBERON_0001630, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid152159, _:genid152161 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png"^^xsd:anyURI . obo:UBERON_0010948 obo:IAO_0000115 "A muscle organ that attaches_to a clavicle and attaches_to a occipital bone." ; oboInOwl:hasDbXref "EMAPA:37688", "MA:0002276", "NCIT:C52895" ; oboInOwl:hasExactSynonym "cleido-occipitalis", "cleido-occipitalis muscle", "cleidooccipital" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010948" ; a owl:Class ; rdfs:comment "Some studies have indicated a supernumerary cleido-occipital muscle more or less separate from the sterno-cleido-mastoid muscle; The frequency of cleido-occipital muscle occurrence has been reported up to 33%" ; rdfs:label "cleidooccipital muscle" ; rdfs:subClassOf obo:UBERON_0000933 ; owl:equivalentClass _:genid150126 . obo:UBERON_0010949 obo:IAO_0000115 "A muscle organ that has_muscle_insertion a occipital bone and has_muscle_origin a sternum." ; oboInOwl:hasDbXref "EMAPA:37702", "MA:0002385", "NCIT:C53069", "UMLS:C1710196" ; oboInOwl:hasExactSynonym "sternooccipital" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010949" ; a owl:Class ; rdfs:label "sternooccipital muscle" ; rdfs:subClassOf obo:UBERON_0002377 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000975 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001676 ] ) ] . obo:UBERON_0010952 obo:IAO_0000115 "A belly of the occipitofrontalis muscle that is near the frontal bone." ; oboInOwl:hasDbXref "FMA:46757", "SCTID:368680005", "Wikipedia:Frontalis_muscle" ; oboInOwl:hasExactSynonym "frontal belly of occipitofrontalis", "frontal part of occipitofrontalis", "frontalis", "frontalis muscke", "orbito-temporo-auricularis", "venter frontalis (musculus occipitofrontalis)", "venter frontalis musculus occipitofrontalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "frontal belly of occipitofrontalis muscle", "venter frontalis musculi occipitofrontalis" ; oboInOwl:id "UBERON:0010952" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "frontalis muscle belly" ; rdfs:subClassOf obo:UBERON_0010938, _:genid152188 ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/be/Musculus_frontalis.png"^^xsd:anyURI . obo:UBERON_0010953 obo:IAO_0000115 "The nasalis (compressor naris) is a sphincter-like muscle of the nose whose function is to compress the nasal cartilage. It consists of two parts, transverse and alar: The transverse part arises from the maxilla, above and lateral to the incisive fossa; its fibers proceed upward and medially, expanding into a thin aponeurosis which is continuous on the bridge of the nose with that of the muscle of the opposite side, and with the aponeurosis of the Procerus. The alar part is attached at one end to the greater alar cartilage, and at the other to the integument at the point of the nose. Other sources divide it into 'Compressor nasalis' and 'Dilator nasalis'." ; oboInOwl:hasDbXref "FMA:46770", "SCTID:244732001", "Wikipedia:Nasalis_muscle" ; oboInOwl:hasExactSynonym "nasalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "compressor naris", "compressor narium minor", "compressor nasi", "musculus nasalis" ; oboInOwl:id "UBERON:0010953" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "nasalis muscle" ; rdfs:subClassOf obo:UBERON_0008522, _:genid152201, _:genid152203, _:genid152205 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Nasalis.png"^^xsd:anyURI . obo:UBERON_0010955 oboInOwl:hasDbXref "EHDAA2:0002079" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010955" ; a owl:Class ; rdfs:label "trapezius pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152214, _:genid152216 . obo:UBERON_0010959 obo:IAO_0000115 "Any muscle organ that is part of either the head or the neck." ; oboInOwl:hasDbXref "NCIT:C32716", "UMLS:C0448281" ; oboInOwl:hasExactSynonym "muscle of head or neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle of head and neck" ; oboInOwl:id "UBERON:0010959" ; a owl:Class ; rdfs:label "craniocervical muscle" ; rdfs:subClassOf _:genid152222 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0010962 oboInOwl:hasDbXref "EHDAA2:0000459" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010962" ; a owl:Class ; rdfs:label "extensor pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152227 . obo:UBERON_0010963 oboInOwl:hasDbXref "EHDAA2:0003425" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010963" ; a owl:Class ; rdfs:comment "isa row in EHDAA2" ; rdfs:label "trunk and cervical myotome group" ; rdfs:subClassOf obo:UBERON_0003082, _:genid152229 . obo:UBERON_0010970 oboInOwl:hasDbXref "EHDAA2:0000843" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010970" ; a owl:Class ; rdfs:label "intercostal pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152232, _:genid152234, _:genid152236 . obo:UBERON_0010975 oboInOwl:hasDbXref "EHDAA2:0000470" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010975" ; a owl:Class ; rdfs:label "external oblique pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152239, _:genid152241 . obo:UBERON_0010977 oboInOwl:hasDbXref "EHDAA2:0000543" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010977" ; a owl:Class ; rdfs:label "flexor pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152244 . obo:UBERON_0010982 oboInOwl:hasDbXref "EHDAA2:0000933" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010982" ; a owl:Class ; rdfs:label "latissimus dorsi pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152247, _:genid152249 . obo:UBERON_0010983 oboInOwl:hasDbXref "EHDAA2:0000993" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010983" ; a owl:Class ; rdfs:label "levator scapulae pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152252, _:genid152254 . obo:UBERON_0010984 oboInOwl:hasDbXref "EHDAA2:0001423" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010984" ; a owl:Class ; rdfs:label "pectoral pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152257, _:genid152259 . obo:UBERON_0010986 oboInOwl:hasDbXref "EHDAA2:0001833", "EHDAA:5992" ; oboInOwl:hasExactSynonym "serratus anterior pre-muscle mass" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0010986" ; a owl:Class ; rdfs:label "serratus ventralis pre-muscle mass" ; rdfs:subClassOf obo:UBERON_0005865, _:genid152262, _:genid152264 . obo:UBERON_0010996 obo:IAO_0000115 "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." ; oboInOwl:hasDbXref "AEO:0000179", "BTO:0001572", "CALOHA:TS-0055", "EFO:0001902", "EMAPA:35149", "FMA:12264", "GAID:101", "MA:0000487", "MESH:D002358", "NCIT:C32144", "SCTID:305026006", "UMLS:C0007303", "galen:ArticularCartilage" ; oboInOwl:hasExactSynonym "articular cartilage", "cartilago articularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hyaline cartilage", "joint-associated cartilage" ; oboInOwl:id "UBERON:0010996" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas, core:pheno_slim, core:uberon_slim, core:vertebrate_core ; a owl:Class ; rdfs:label "articular cartilage of joint" ; rdfs:subClassOf obo:UBERON_0001994, _:genid152268 . obo:UBERON_0011004 obo:IAO_0000115 "A cartilage element that is part of a splanchnocranium." ; oboInOwl:hasDbXref "EFO:0003689", "TAO:0001460", "ZFA:0001460" ; oboInOwl:hasExactSynonym "pharyngeal arch cartilages", "splanchnocranium cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011004" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "pharyngeal arch cartilage" ; rdfs:subClassOf obo:UBERON_0003933, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002539 ], _:genid152281 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 ] ) ] . obo:UBERON_0011024 obo:IAO_0000115 "The extrinsic extensor muscles of the hand are located in the back of the forearm and have long tendons connecting them to bones in the hand, where they exert their action." ; oboInOwl:hasDbXref "Wikipedia:Extrinsic_extensor_muscles_of_the_hand" ; oboInOwl:hasExactSynonym "extrinsic extensor muscle of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011024" ; a owl:Class ; rdfs:label "extrinsic extensor muscle of manus" ; owl:equivalentClass _:genid150219 . obo:UBERON_0011085 obo:IAO_0000115 "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]." ; obo:UBPROP_0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" ; oboInOwl:hasDbXref "EFO:0003659", "TAO:0001272", "VHOG:0000511", "ZFA:0001272" ; oboInOwl:hasExactSynonym "dorsal visceral arch 1", "upper pharyngeal jaw" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal mandibular arch", "dorsal pharyngeal arch 1", "dorsal visceral arch 1", "palatoquadrate arch", "upper jaw", "upper pharyngeal jaw" ; oboInOwl:id "UBERON:0011085" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "palatoquadrate arch" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ], _:genid152297 . obo:UBERON_0011088 obo:IAO_0000115 "A ligament that is part of a knee joint." ; oboInOwl:hasDbXref "FMA:44580", "SCTID:182440009" ; oboInOwl:hasExactSynonym "knee joint ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011088" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ligament of knee joint" ; rdfs:subClassOf obo:UBERON_0008846 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001485 ] ) ] . obo:UBERON_0011090 obo:IAO_0000115 "A skeleton of pelvic girdle that is part of a right pelvic girdle region." ; oboInOwl:hasDbXref "FMA:87593" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011090" ; a owl:Class ; rdfs:label "skeleton of right pelvic girdle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007832 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011092 ] ) ] . obo:UBERON_0011091 obo:IAO_0000115 "A skeleton of pelvic girdle that is part of a left pelvic girdle region." ; oboInOwl:hasDbXref "FMA:87594" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011091" ; a owl:Class ; rdfs:label "skeleton of left pelvic girdle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007832 _:genid150254 ) ] . obo:UBERON_0011092 obo:IAO_0000115 "A pelvic girdle region that is in the right side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:16582" ; oboInOwl:hasExactSynonym "right pelvic girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011092" ; a owl:Class ; rdfs:label "right pelvic girdle region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011090 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001271 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0011093 obo:IAO_0000115 "A pelvic girdle region that is in the left side of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:16583" ; oboInOwl:hasExactSynonym "left pelvic girdle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011093" ; a owl:Class ; rdfs:label "left pelvic girdle region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011091 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001271 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0011094 obo:IAO_0000115 "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." ; obo:RO_0002175 obo:NCBITaxon_7764 ; obo:UBPROP_0000012 "This class is a superclass of individual vertebral cartilage condensations. Note that EHDAA2 represents these as condensation groups" ; oboInOwl:hasDbXref "EMAPA:32669", "VHOG:0000584" ; oboInOwl:hasExactSynonym "vertebral cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011094" ; a owl:Class ; rdfs:label "vertebra cartilage element" ; rdfs:subClassOf obo:UBERON_0010913, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011095 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002412 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0011095 obo:IAO_0000115 "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." ; oboInOwl:hasDbXref "EMAPA:32671", "VHOG:0000582" ; oboInOwl:hasExactSynonym "vertebral pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011095" ; a owl:Class ; rdfs:label "vertebra pre-cartilage condensation" ; rdfs:subClassOf _:genid150285, _:genid152354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 _:genid150283 ) ] . obo:UBERON_0011096 obo:IAO_0000115 "The lacrimal nerve is the smallest of the three branches of the ophthalmic division of the trigeminal nerve." ; oboInOwl:hasDbXref "FMA:52628", "NCIT:C32908", "SCTID:280218007", "Wikipedia:Lacrimal_nerve" ; oboInOwl:hasExactSynonym "nervus lacrimalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011096" ; a owl:Class ; rdfs:label "lacrimal nerve" ; rdfs:subClassOf _:genid152363 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 _:genid150291 ) ] . obo:UBERON_0011104 obo:IAO_0000115 "An epiphysis that is part of a metacarpal bone of digit 5." ; oboInOwl:hasDbXref "FMA:86330" ; oboInOwl:hasExactSynonym "fifth metacarpal bone epiphysis", "metacarpal 5 epiphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011104" ; a owl:Class ; rdfs:label "epiphysis of fifth metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003649 ] ) ] . obo:UBERON_0011107 obo:IAO_0000115 "A synovial joint that is part of a pelvic girdle region." ; oboInOwl:hasDbXref "FMA:35173", "NCIT:C32890", "UMLS:C0827002" ; oboInOwl:hasExactSynonym "joint of pelvic girdle", "pelvic girdle joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011107" ; a owl:Class ; rdfs:label "synovial joint of pelvic girdle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0007830 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001271 ] ) ] . obo:UBERON_0011108 obo:IAO_0000115 "A synovial joint that is part of a pectoral girdle region." ; obo:UBPROP_0000012 "in FMA, these are part of the bony pectoral girdle" ; oboInOwl:hasDbXref "FMA:35243", "SCTID:303080001" ; oboInOwl:hasExactSynonym "joint of shoulder girdle", "pectoral girdle joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011108" ; a owl:Class ; rdfs:label "synovial joint of pectoral girdle" ; rdfs:subClassOf obo:UBERON_0008114, [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0007829 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_0011110 obo:IAO_0000115 "The humeroulnar joint, is part of the elbow-joint or the Olecron Joint, between the ulna and humerus bones is the simple hinge-joint, which allows for movements of flexion, extension and circumduction. The Humero-Ulnar Joint is the junction of trochlear notch of the ulna and the trochlea of the humerus. Owing to the obliquity of the trochlea of the humerus, this movement does not take place in the antero-posterior plane of the body of the humerus. When the forearm is extended and supinated, the axis of the arm and forearm are not in the same line; the arm forms an obtuse angle with the forearm. During flexion, however, the forearm and the hand tend to approach the middle line of the body, and thus enable the hand to be easily carried to the face. The accurate adaptation of the trochlea of the humerus, with its prominences and depressions, to the semilunar notch of the ulna, prevents any lateral movement. Flexion is produced by the action of the Biceps brachii and Brachialis, assisted by the Brachioradialis, with a tiny contribution from the muscles arising from the medial epicondyle of the humerus. Extension is produced by the Triceps brachii and AnconC&us, with a tiny contribution from the muscles arising from the lateral epicondyle of the humerus, such as the Extensor digitorum communis." ; oboInOwl:hasDbXref "FMA:38854", "SCTID:303064006", "Wikipedia:Humeroulnar_joint" ; oboInOwl:hasExactSynonym "articulatio humeroulnaris", "humero-ulnar joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011110" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "humeroulnar joint" ; rdfs:subClassOf obo:UBERON_0002217, _:genid152396 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray329.png"^^xsd:anyURI . obo:UBERON_0011111 obo:IAO_0000115 "A hinge joint between the head of the radius and the capitulum of the humerus." ; oboInOwl:hasDbXref "FMA:38855", "SCTID:182171008", "Wikipedia:Humeroradial_joint" ; oboInOwl:hasExactSynonym "articulatio humeroradialis", "humero-radial joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011111" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "humeroradial joint" ; rdfs:subClassOf _:genid152407 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray329.png"^^xsd:anyURI . obo:UBERON_0011112 obo:IAO_0000115 "A joint that connects the tibia and the fibula." ; obo:IAO_0000116 "we include location as part of the logical definition to prevent accidental classification of ankle joints as tibiofibular joints" ; oboInOwl:hasDbXref "FMA:35181", "SCTID:244554002", "Wikipedia:Tibiofibular_joint" ; oboInOwl:hasExactSynonym "fibulatibial joint", "fibulotibial joint", "tibiafibular joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011112" ; a owl:Class ; rdfs:label "tibiofibular joint" ; rdfs:subClassOf obo:UBERON_0002210 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0011118 obo:IAO_0000115 "The tarsometatarsal articulations are arthrodial joints in the pes." ; oboInOwl:hasDbXref "FMA:35216", "SCTID:182222008", "Wikipedia:Tarsometatarsal_articulations" ; oboInOwl:hasExactSynonym "tarso-metatarsal join" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Lisfranc joint", "articulationes tarsometatarsales", "cuboideometatarsal", "tarsometatarsal", "tarsometatarsal articulation" ; oboInOwl:id "UBERON:0011118" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tarsometatarsal joint" ; rdfs:subClassOf obo:UBERON_0002217, _:genid150354 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001447 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray355.png"^^xsd:anyURI, "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png"^^xsd:anyURI . obo:UBERON_0011119 obo:IAO_0000115 "The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones." ; oboInOwl:hasBroadSynonym "CMJ", "carpometacarpal" ; oboInOwl:hasDbXref "FMA:35287", "MESH:D052737", "NCIT:C32265", "SCTID:361842002", "UMLS:C0224620", "Wikipedia:Carpometacarpal_joint" ; oboInOwl:hasExactSynonym "articulationes carpometacarpeæ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpometacarpal articulation" ; oboInOwl:id "UBERON:0011119" ; a owl:Class ; rdfs:label "carpometacarpal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001435 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray335.png"^^xsd:anyURI . obo:UBERON_0011120 obo:IAO_0000115 "A skeletal joint that connects a laryngeal cartilage." ; oboInOwl:hasDbXref "FMA:55100" ; oboInOwl:hasExactSynonym "joint of larynx", "laryngeal articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011120" ; a owl:Class ; rdfs:label "laryngeal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001739 ] ) ] . obo:UBERON_0011121 obo:IAO_0000115 "The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the thyroid cartilage." ; oboInOwl:hasDbXref "FMA:55101", "NCIT:C32402", "SCTID:361944002", "UMLS:C0225540", "Wikipedia:Cricothyroid_articulation" ; oboInOwl:hasExactSynonym "cricothyroid articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crico-thyroid joint" ; oboInOwl:id "UBERON:0011121" ; a owl:Class ; rdfs:label "cricothyroid joint" ; rdfs:subClassOf obo:UBERON_0011120, _:genid152465 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg"^^xsd:anyURI . obo:UBERON_0011122 obo:IAO_0000115 "The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the arytenoid cartilage." ; oboInOwl:hasDbXref "FMA:55102", "NCIT:C32397", "SCTID:361945001", "UMLS:C0225555", "Wikipedia:Cricoarytenoid_articulation" ; oboInOwl:hasExactSynonym "crico-arytenoid joint", "cricoarytenoid articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crico-arytenoid joint" ; oboInOwl:id "UBERON:0011122" ; a owl:Class ; rdfs:label "cricoarytenoid joint" ; rdfs:subClassOf obo:UBERON_0011120, _:genid152478 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001740 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray960.png"^^xsd:anyURI . obo:UBERON_0011130 oboInOwl:hasDbXref "EMAPA:18714" ; oboInOwl:hasExactSynonym "temporo-mandibular joint primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011130" ; a owl:Class ; rdfs:label "temporomandibular joint primordium" ; rdfs:subClassOf obo:UBERON_0001048, _:genid152485 . obo:UBERON_0011131 obo:IAO_0000115 "A skeletal joint that connects two adjacent metacarpals[FMA,modified]." ; oboInOwl:hasDbXref "FMA:35288", "SCTID:303065007", "Wikipedia:Intermetacarpal_articulations" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intermetacarpal", "intermetacarpal articulation" ; oboInOwl:id "UBERON:0011131" ; a owl:Class ; rdfs:label "intermetacarpal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004453 ], _:genid152494 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150413 ] . obo:UBERON_0011132 obo:IAO_0000115 "A skeletal joint that connects two carpal bones." ; oboInOwl:hasDbXref "FMA:35292", "NCIT:C32264", "SCTID:182176003", "UMLS:C1262468", "Wikipedia:Intercarpal_articulations" ; oboInOwl:hasExactSynonym "carpal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intercarpal", "intercarpal articulation", "midcarpal articulation" ; oboInOwl:id "UBERON:0011132" ; a owl:Class ; rdfs:label "intercarpal joint" ; rdfs:subClassOf obo:UBERON_0002217, _:genid152504, _:genid152506 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150423 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/37/Gray336.png"^^xsd:anyURI . obo:UBERON_0011133 obo:IAO_0000115 "A joint that connects two adjacent metatarsals." ; obo:UBPROP_0000008 "In humans: The base of the first metatarsal is not connected with that of the second by any ligaments; in this respect the great toe resembles the thumb" ; oboInOwl:hasDbXref "FMA:35219", "SCTID:361868009", "Wikipedia:Intermetatarsal_articulations" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011133" ; a owl:Class ; rdfs:label "intermetatarsal joint" ; rdfs:subClassOf obo:UBERON_0002217, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000983 ], _:genid152520 ; owl:equivalentClass _:genid150435 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png"^^xsd:anyURI . obo:UBERON_0011134 obo:IAO_0000115 "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." ; oboInOwl:hasDbXref "FMA:7491" ; oboInOwl:hasExactSynonym "solid joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011134" ; a owl:Class ; rdfs:label "nonsynovial joint" ; rdfs:subClassOf obo:UBERON_0000982 . obo:UBERON_0011135 obo:IAO_0000115 "A cartilage element that lies between two successive vertebral centra." ; obo:UBPROP_0000001 "Block of cartilage, which usually ossifies, that lies between successive vertebral centra.[AAO]" ; oboInOwl:hasDbXref "AAO:0000795" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011135" ; a owl:Class ; rdfs:label "intervertebral cartilage" ; rdfs:subClassOf obo:UBERON_0007844, _:genid152531, _:genid152533 ; owl:equivalentClass _:genid150447 . obo:UBERON_0011136 obo:IAO_0000115 "Ligament that joins successive centra. Important in controlling the stiffness of the vertebral column when it flexes." ; oboInOwl:hasBroadSynonym "intervertebral ligament", "vertebral centrum ligament" ; oboInOwl:hasDbXref "FMA:31892", "SCTID:244590009" ; oboInOwl:hasExactSynonym "vertebral column ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011136" ; a owl:Class ; rdfs:label "ligament of vertebral column" ; rdfs:subClassOf _:genid150459 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001075 ] ) ] . obo:UBERON_0011137 obo:IAO_0000115 "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." ; oboInOwl:hasDbXref "FMA:7483" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011137" ; a owl:Class ; rdfs:label "axial skeletal system" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000982 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0005944 ] . obo:UBERON_0011138 obo:IAO_0000115 "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints." ; oboInOwl:hasBroadSynonym "axial skeletal system" ; oboInOwl:hasDbXref "FMA:302077" ; oboInOwl:hasExactSynonym "post-cranial axial skeletal system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011138" ; a owl:Class ; rdfs:label "postcranial axial skeletal system" ; rdfs:seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000075, _:genid152549 . obo:UBERON_0011139 obo:IAO_0000115 "Any synovial joint that is part of a (free) limb." ; oboInOwl:hasDbXref "FMA:258776" ; oboInOwl:hasExactSynonym "synovial joint of free limb segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011139" ; a owl:Class ; rdfs:comment "Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses." ; rdfs:label "synovial limb joint" ; rdfs:subClassOf obo:UBERON_0003657 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150471 ] . obo:UBERON_0011141 obo:IAO_0000115 "Ossicle that is part of the appendicular skeleton." ; oboInOwl:hasDbXref "VSAO:0000131", "XAO:0004194" ; oboInOwl:hasExactSynonym "ossicle of appendicular skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011141" ; a owl:Class ; rdfs:comment "Examples of appendicular ossicles include the patella and meniscus of the knee joint." ; rdfs:label "appendicular ossicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ] ) ] . obo:UBERON_0011142 obo:IAO_0000115 "Ossicle that is part of the axial skeleton." ; oboInOwl:hasDbXref "VSAO:0000133" ; oboInOwl:hasExactSynonym "ossicle of axial skeleton", "ossicle of postcranial-axial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vertebral ossicle" ; oboInOwl:id "UBERON:0011142" ; a owl:Class ; rdfs:comment "Examples of axial ossicles include the ossified tendons adjacent to the neural spines of the vertebral column." ; rdfs:label "axial ossicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150483 ] . obo:UBERON_0011143 obo:IAO_0000115 "Subdivision of urinary system which consists of the kidney and the ureters." ; oboInOwl:hasDbXref "FMA:45658", "NCIT:C61107", "SCTID:181413006", "galen:UpperUrinaryTract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011143" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper urinary tract" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000056 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002113 ], _:genid152573, _:genid152577 . obo:UBERON_0011144 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "BTO:0000030", "EMAPA:19166", "MA:0002267", "SCTID:181670005", "SCTID:368101007", "Wikipedia:Adductor_muscles_of_the_hip" ; oboInOwl:hasExactSynonym "adductor group (leg)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscle of adductor group" ; oboInOwl:id "UBERON:0011144" ; a owl:Class ; rdfs:label "adductor muscle of hip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001272 ], _:genid152584 ; owl:equivalentClass _:genid150495 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e2/Anterior_Hip_Muscles_2.PNG"^^xsd:anyURI . obo:UBERON_0011145 obo:IAO_0000115 "A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction." ; obo:UBPROP_0000001 "A muscle that brings a body part closer to the sagittal plane of the body.[TAO]" ; obo:UBPROP_0000002 "relationship loss: subclass cranial muscle (TAO:0001953)[TAO]" ; obo:UBPROP_0000012 "we place the TAO class here even though it is a cranial muscle; it is defined functionally" ; oboInOwl:hasDbXref "FMA:74998", "TAO:0002136", "Wikipedia:Adductor_muscle", "ZFA:0005268" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "adductor" ; oboInOwl:id "UBERON:0011145" ; oboInOwl:inSubset core:functional_classification ; a owl:Class ; rdfs:label "adductor muscle" ; rdfs:subClassOf obo:UBERON_0014892 . obo:UBERON_0011148 obo:IAO_0000115 "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." ; oboInOwl:hasDbXref "BTO:0003751", "EMAPA:37970", "Wikipedia:Submucosal_glands" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011148" ; a owl:Class ; rdfs:label "submucosal gland" ; rdfs:subClassOf _:genid152597 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150508 ] . obo:UBERON_0011151 obo:IAO_0000115 "A muscle whose action is to depress the lower jaw." ; obo:UBPROP_0000001 "Muscle located on ventral side of the head, linking the ventral hyoid arch to the dentary. Innervated by ramus mandibularis V and ramus hyoides VII.[TAO]", "Muscle that pulls the hyoid apparatus forward and depresses the lower jaw.[AAO]" ; obo:UBPROP_0000002 "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" ; obo:UBPROP_0000005 "Source: Winterbottom, R. 1973. A Descriptive Synonymy of the Striated Muscles of the Teleostei. Proceedings of the Academy of Natural Sciences of Philadelphia, Vol. 125 (1973), pp. 225-317.[TAO]" ; obo:UBPROP_0000008 "In amphibians, 'Muscle that pulls the hyoid apparatus forward and depresses the lower jaw.' [AAO:0010655]. 'The protractor hyoideus muscle in teleosts is commonly, albeit mistakenly, referred to as the geniohyoideus muscle, which is involved in the coracomandibularis coupling. According to Edgeworth (1935) and Winterbottom (1974), the protractor hyoideus is composed of a fusion of the intermandibularis posterior and the interhyoideus muscles which resulted in the protractor hyoideus which spans the hyoid and mandible. The intermandibularis spans the mandible while the closely apposed interhyoideus spans the hyoid in other fishes. Furthermore, they concluded that any muscle that is homologous to the geniohyoideus (coracomandibularis coupling) in other lower vertebrates has been lost in teleosts, as well as gars. However, the protractor hyoideus muscle is functionally analogous to the coracomandibularis coupling of other vertebrates and so we use it in our discussion to show the phylogenetically broad roles of these couplings in jaw mechanics.'" ; oboInOwl:hasDbXref "AAO:0010655", "TAO:0000612", "XAO:0004127" ; oboInOwl:hasNarrowSynonym "branchiomandibularis", "coracomandibularis", "depressor gnathalis", "geniohyoideus", "geniohyoideus muscle", "geniothoracis", "protractor hyoidei", "protractor hyoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011151" ; a owl:Class ; rdfs:label "jaw depressor muscle" ; rdfs:subClassOf obo:UBERON_0005493 . obo:UBERON_0011152 oboInOwl:hasDbXref "AAO:0010371", "TAO:0001401", "XAO:0003178", "ZFA:0001401" ; oboInOwl:hasExactSynonym "dorsal hyoid arch", "dorsal pharyngeal arch 2 skeleton", "dorsal visceral arch 2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011152" ; a owl:Class ; rdfs:label "dorsal hyoid arch skeleton" ; rdfs:subClassOf obo:UBERON_0010912, _:genid152615 . obo:UBERON_0011156 obo:IAO_0000115 "Subdivision of skull that consists of the facial bones." ; oboInOwl:hasDbXref "EHDAA2:0002206", "EHDAA:8361", "EMAPA:18022", "FMA:53673", "MA:0000318", "Wikipedia:Facial_skeleton" ; oboInOwl:hasExactSynonym "facial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial bone", "ossa facialia", "ossa faciei", "viscerocranium" ; oboInOwl:id "UBERON:0011156" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "facial skeleton" ; rdfs:subClassOf obo:UBERON_0011158, _:genid152620, _:genid152622 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg"^^xsd:anyURI . obo:UBERON_0011158 obo:IAO_0000115 "The skull can be divided into two: the neurocranium and the facial skeleton." ; oboInOwl:hasDbXref "FMA:54964" ; oboInOwl:hasExactSynonym "skull subdivision", "subdivision of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011158" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "primary subdivision of skull" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] . obo:UBERON_0011159 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011159" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "primary subdivision of cranial skeletal system" ; rdfs:subClassOf obo:UBERON_0000075, _:genid150545 . obo:UBERON_0011160 obo:IAO_0000115 "A suture joining a nasal bone to another bone." ; oboInOwl:hasDbXref "SCTID:368992007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011160" ; a owl:Class ; rdfs:label "nasal suture" ; owl:equivalentClass _:genid150547 . obo:UBERON_0011164 obo:IAO_0000115 "A bone that is part of a neurocranium [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35238", "MA:0001478", "SCTID:120229002" ; oboInOwl:hasExactSynonym "chondrocranium bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011164" ; a owl:Class ; rdfs:label "neurocranium bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 ] ) ] . obo:UBERON_0011171 obo:IAO_0000115 "Synovial joint that articulates bones of upper and lower jaw." ; obo:UBPROP_0000008 "Some synapsids retained two pairs of jaw joints - quadrate-articular and tempero-mandibular, but this unusual paired condition did not last long" ; oboInOwl:hasBroadSynonym "jaw joint" ; oboInOwl:hasDbXref "NCIT:C32888" ; oboInOwl:hasNarrowSynonym "craniomandibular joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011171" ; a owl:Class ; rdfs:label "joint connecting upper and lower jaws" ; rdfs:subClassOf obo:UBERON_0002217 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150559 ] . obo:UBERON_0011185 obo:IAO_0000115 "A sphincter muscle that is part of the gastrointestinal system." ; oboInOwl:hasDbXref "NCIT:C32669", "UMLS:C1517464" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011185" ; a owl:Class ; rdfs:label "gastrointestinal sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150568 ] . obo:UBERON_0011189 obo:IAO_0000115 "A lamina propria that is part of a large intestine." ; oboInOwl:hasDbXref "FMA:15654", "NCIT:C49298", "UMLS:C1708644" ; oboInOwl:hasExactSynonym "lamina propria of mucosa of large intestine", "large intestinal lamina propria", "large intestine lamina propria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011189" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lamina propria of large intestine" ; rdfs:subClassOf _:genid152667, _:genid152669 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0011191 obo:IAO_0000115 "Ophthalmic veins are veins which drain the eye. More specifically, they can refer to: Superior ophthalmic vein Inferior ophthalmic vein." ; oboInOwl:hasDbXref "EHDAA2:0004113", "EMAPA:19313", "Wikipedia:Ophthalmic_veins", "XAO:0004169" ; oboInOwl:hasExactSynonym "opthalmic vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vena ophthalmica" ; oboInOwl:id "UBERON:0011191" ; a owl:Class ; rdfs:label "ophthalmic vein" ; rdfs:subClassOf obo:UBERON_0009141 ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png"^^xsd:anyURI . obo:UBERON_0011192 obo:IAO_0000115 "The superior ophthalmic vein begins at the inner angle of the orbit in a vein named the nasofrontal which communicates anteriorly with the angular vein; it pursues the same course as the ophthalmic artery, and receives tributaries corresponding to the branches of that vessel. Forming a short single trunk, it passes between the two heads of the Rectus lateralis and through the medial part of the superior orbital fissure, and ends in the cavernous sinus. The ethmoidal veins drain into the superior ophthalmic vein. Vorticose veins also drain into the superior ophthalmic vein." ; oboInOwl:hasDbXref "FMA:51246", "SCTID:149481004", "Wikipedia:Superior_ophthalmic_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior ethmoidal vein", "posterior ethmoidal vein", "superior ophthalmic", "superior opthalmic vein" ; oboInOwl:id "UBERON:0011192" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "superior ophthalmic vein" ; rdfs:subClassOf obo:UBERON_0011191, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0003712 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png"^^xsd:anyURI . obo:UBERON_0011197 obo:IAO_0000115 "An epithelium that is part of a parathyroid gland." ; oboInOwl:hasDbXref "CALOHA:TS-2141", "NCIT:C48258", "UMLS:C1709466" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011197" ; a owl:Class ; rdfs:label "parathyroid epithelium" ; rdfs:subClassOf obo:UBERON_0000486, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004117 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002260 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) ] . obo:UBERON_0011198 obo:IAO_0000115 "A muscle layer that is part of a large intestine." ; oboInOwl:hasDbXref "FMA:14971", "NCIT:C32927", "UMLS:C0734205" ; oboInOwl:hasExactSynonym "muscular coat of large intestine", "muscular layer of large intestine", "muscularis externa of large intestine", "tunica muscularis intestini crassi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011198" ; a owl:Class ; rdfs:label "muscle layer of large intestine" ; rdfs:subClassOf _:genid152697 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ) ] . obo:UBERON_0011200 obo:IAO_0000115 "The sacrococcygeal symphysis (sacrococcygeal articulation, articulation of the sacrum and coccyx) is an amphiarthrodial joint, formed between the oval surface at the apex of the sacrum, and the base of the coccyx. It is a slightly moveable joint which is frequently, partially or completely, obliterated in old age, homologous with the joints between the bodies of the vertebrae." ; oboInOwl:hasDbXref "FMA:16210", "NCIT:C33506", "UMLS:C0224593", "Wikipedia:Sacrococcygeal_symphysis" ; oboInOwl:hasExactSynonym "sacrococcygeal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sacrococcygeal joint" ; oboInOwl:id "UBERON:0011200" ; a owl:Class ; rdfs:label "sacrococcygeal symphysis" ; rdfs:subClassOf obo:UBERON_0001468 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001350 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003690 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7f/Gray320.png"^^xsd:anyURI . obo:UBERON_0011201 obo:IAO_0000115 "A muscle layer that is part of a small intestine." ; oboInOwl:hasDbXref "FMA:14932", "NCIT:C33569", "SCTID:362145004", "UMLS:C0227269" ; oboInOwl:hasExactSynonym "muscular coat of small intestine", "muscular layer of small intestine", "muscularis externa of small intestine", "small intestine muscularis propria", "tunica muscularis (intestinum tenue)", "tunica muscularis intestini tenuis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011201" ; a owl:Class ; rdfs:label "muscle layer of small intestine" ; rdfs:subClassOf _:genid152720 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_0011202 obo:IAO_0000115 "An epithelium that is part of a urachus." ; oboInOwl:hasDbXref "EHDAA2:0004725", "NCIT:C54210", "UMLS:C1711256" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011202" ; a owl:Class ; rdfs:label "urachus epithelium" ; rdfs:subClassOf obo:UBERON_0003914 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002068 ] ) ] . obo:UBERON_0011203 obo:IAO_0000115 "Mesenchyme that is part of a developing urachus." ; oboInOwl:hasDbXref "EHDAA2:0004726" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011203" ; a owl:Class ; rdfs:label "urachus mesenchyme" ; rdfs:subClassOf obo:UBERON_0007524 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002068 ] ) ] . obo:UBERON_0011215 obo:IAO_0000115 "A multi cell part structure that is part of a central nervous system." ; oboInOwl:hasDbXref "FMA:83143" ; oboInOwl:hasExactSynonym "cell part cluster of neuraxis", "neuraxis layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011215" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "central nervous system cell part cluster" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005162 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0011216 obo:IAO_0000115 "A subdivision of an anatomical system." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FBbt:00007330", "FMA:67509", "SCTID:91690000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011216" ; oboInOwl:inSubset core:common_anatomy, core:upper_level ; a owl:Class ; rdfs:label "organ system subdivision" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000467 ] . obo:UBERON_0011220 obo:IAO_0000115 "The mastoid process is a conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. It is located just behind the external acoustic meatus, and lateral to the styloid process. Its size and form vary somewhat; it is larger in the male than in the female. This process serves for the attachment of the posterior belly of the digastric, sternocleidomastoid, splenius capitis, and longissimus capitis muscles. The word is derived from the Greek 'masto-', alluding to its resemblance to the breast." ; oboInOwl:hasDbXref "FMA:52872", "NCIT:C12503", "SCTID:304336002", "UMLS:C0446908", "Wikipedia:Mastoid_process" ; oboInOwl:hasExactSynonym "mastoid process", "mastoid process of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mastoid", "processus mastoideus ossis temporalis" ; oboInOwl:id "UBERON:0011220" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mastoid process of temporal bone" ; rdfs:subClassOf obo:UBERON_0000075, _:genid152754 . obo:UBERON_0011222 obo:UBPROP_0000001 "Muscles within the eye (bulbus oculi).[AAO]" ; oboInOwl:hasDbXref "AAO:0010038", "EMAPA:18808", "FMA:49150" ; oboInOwl:hasExactSynonym "intrinsic muscle of eyeball", "intrinsic ocular muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011222" ; a owl:Class ; rdfs:label "intra-ocular muscle" ; rdfs:subClassOf obo:UBERON_0001630, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], _:genid152763 . obo:UBERON_0011233 obo:IAO_0000115 "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa." ; oboInOwl:hasBroadSynonym "synovium" ; oboInOwl:hasDbXref "BTO:0001823", "FMA:40878", "Wikipedia:Synovial_sheath" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011233" ; a owl:Class ; rdfs:comment "Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath]" ; rdfs:label "synovial membrane of synovial tendon sheath" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007616 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000304 ] ) ] . obo:UBERON_0011234 oboInOwl:hasDbXref "FMA:40877" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011234" ; a owl:Class ; rdfs:label "fibrous membrane of synovial tendon sheath" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000304 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011824 ] ) ] . obo:UBERON_0011241 obo:IAO_0000115 "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." ; obo:IAO_0000232 "currently this is not restricted to skeletal elements, unlike UBERONREF:0000007" ; oboInOwl:hasDbXref "AAO:0000986" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011241" ; a owl:Class ; rdfs:label "ethmoid region" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003112 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005945 ] . obo:UBERON_0011249 obo:IAO_0000115 "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." ; obo:UBPROP_0000001 "Skeletal system which consists of the appendicular skeleton plus associated joints.[VSAO]" ; oboInOwl:hasDbXref "FMA:7484", "VHOG:0001666", "VSAO:0000306" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011249" ; a owl:Class ; rdfs:label "appendicular skeletal system" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000982 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002091 ] . obo:UBERON_0011250 obo:IAO_0000115 "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011250" ; a owl:Class ; rdfs:label "autopod bone" ; rdfs:subClassOf obo:UBERON_0015063, _:genid150694 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015063 _:genid150692 ) ] . obo:UBERON_0011256 obo:IAO_0000115 "Moist, hairless, crenelated area around nostrils of some mammals." ; obo:RO_0002161 obo:NCBITaxon_9475 ; obo:UBPROP_0000008 "Absent in Tarsiers" ; oboInOwl:hasDbXref "Wikipedia:Rhinarium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011256" ; a owl:Class ; rdfs:label "rhinarium" ; rdfs:subClassOf obo:UBERON_0003102, _:genid150696, [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0005928 ] . obo:UBERON_0011265 obo:IAO_0000115 "A carpometacarpal joint that connects to metacarpal 1." ; obo:UBPROP_0000008 "In humans it connects the trapezium to the first metacarpal bone, plays an irreplaceable role in the normal functioning of the thumb. The most important joint connecting the wrist to the metacarpus, osteoarthritis of the TMC is a severely disabling condition; up to twenty times more common among old women than in average" ; oboInOwl:hasDbXref "FMA:35421", "SCTID:361843007", "Wikipedia:Carpometacarpal_joint#Thumb" ; oboInOwl:hasExactSynonym "carpometacarpal joint of digit I", "carpometacarpal joint of pollex", "carpometacarpal joint of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "TMJ", "carpometacarpal joint of the thumb", "trapeziometacarpal joint" ; oboInOwl:id "UBERON:0011265" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "carpometacarpal joint of digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011119 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003645 ] ) ] . obo:UBERON_0011270 obo:IAO_0000115 "The part of the trunk that is in the dorsum[cjm]." ; obo:UBPROP_0000008 "In humans, the subdivision of trunk which is demarcated from the trunk proper by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines, the external surface of the posterior abdominal wall; together with the trunk proper, it constitutes the trunk[FMA]" ; oboInOwl:hasDbXref "EMAPA:35162", "FMA:25056", "MA:0000020", "Wikipedia:Human_back" ; oboInOwl:hasExactSynonym "back of trunk", "dorsal part of trunk", "dorsum of trunk", "trunk back" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011270" ; a owl:Class ; rdfs:label "dorsal trunk" ; rdfs:subClassOf obo:UBERON_0009569, _:genid152808 . obo:UBERON_0011272 obo:IAO_0000116 "compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm'" ; oboInOwl:hasDbXref "EHDAA2:0001845" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "basal cell layer of skin", "outer epithelium of body" ; oboInOwl:id "UBERON:0011272" ; a owl:Class ; rdfs:label "embryonic skin basal layer" ; rdfs:subClassOf obo:UBERON_0000490, _:genid152815, _:genid152817 . obo:UBERON_0011273 obo:IAO_0000115 "A nail that is part of a manual digit 1." ; oboInOwl:hasDbXref "EMAPA:18734", "FMA:54329", "SCTID:181584008" ; oboInOwl:hasExactSynonym "claw of digit 1 of fore-paw", "nail of manual digit I", "nail of thumb", "nail plate of thumb", "thumb nail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011273" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of manual digit 1" ; rdfs:subClassOf obo:UBERON_0009565 ; owl:equivalentClass _:genid150721 . obo:UBERON_0011274 obo:IAO_0000115 "A nail that is part of a manual digit 2." ; oboInOwl:hasDbXref "EMAPA:18735", "FMA:54332", "SCTID:181580004" ; oboInOwl:hasExactSynonym "claw of digit 2 of fore-paw", "index finger nail", "nail of index finger", "nail of manual digit II", "nail of second finger", "nail plate of index finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011274" ; a owl:Class ; rdfs:label "nail of manual digit 2" ; rdfs:subClassOf obo:UBERON_0009565 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0011275 obo:IAO_0000115 "A nail that is part of a manual digit 3." ; oboInOwl:hasDbXref "EMAPA:18736", "FMA:54335", "SCTID:181581000" ; oboInOwl:hasExactSynonym "claw of digit 3 of fore-paw", "middle finger nail", "nail of manual digit III", "nail of middle finger", "nail of third finger", "nail plate of middle finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011275" ; a owl:Class ; rdfs:label "nail of manual digit 3" ; rdfs:subClassOf obo:UBERON_0009565 ; owl:equivalentClass _:genid150744 . obo:UBERON_0011276 obo:IAO_0000115 "A nail that is part of a manual digit 4." ; oboInOwl:hasDbXref "EMAPA:18737", "FMA:54338", "SCTID:181582007" ; oboInOwl:hasExactSynonym "claw of digit 4 of fore-paw", "nail of fourth finger", "nail of manual digit IV", "nail of ring finger", "nail plate of ring finger", "ring finger nail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011276" ; a owl:Class ; rdfs:label "nail of manual digit 4" ; rdfs:subClassOf obo:UBERON_0009565 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0011277 obo:IAO_0000115 "A nail that is part of a manual digit 5." ; oboInOwl:hasDbXref "EMAPA:18738", "FMA:54341", "SCTID:181583002" ; oboInOwl:hasExactSynonym "claw of digit 5 of fore-paw", "little finger nail", "nail of fifth finger", "nail of manual digit V", "nail plate of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nail of little finger" ; oboInOwl:id "UBERON:0011277" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of manual digit 5" ; rdfs:subClassOf obo:UBERON_0009565 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0011278 obo:IAO_0000115 "A nail that is part of a pedal digit 1." ; oboInOwl:hasDbXref "EMAPA:18739", "FMA:54344", "SCTID:181592004" ; oboInOwl:hasExactSynonym "big toe nail", "claw of digit 1 of hind-paw", "nail of big toe", "nail of great toe", "nail of pedal digit I", "nail plate of big toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nail of first toe" ; oboInOwl:id "UBERON:0011278" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of pedal digit 1" ; rdfs:subClassOf obo:UBERON_0009567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0011279 obo:IAO_0000115 "A nail that is part of a pedal digit 2." ; oboInOwl:hasDbXref "EMAPA:18740", "FMA:54347", "SCTID:181593009" ; oboInOwl:hasExactSynonym "claw of digit 2 of hind-paw", "nail of pedal digit II", "nail of second toe", "nail plate of second toe", "second toe nail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011279" ; a owl:Class ; rdfs:label "nail of pedal digit 2" ; rdfs:subClassOf obo:UBERON_0009567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0011280 obo:IAO_0000115 "A nail that is part of a pedal digit 3." ; oboInOwl:hasDbXref "EMAPA:18741", "FMA:54350", "SCTID:181594003" ; oboInOwl:hasExactSynonym "claw of digit 3 of hind-paw", "nail of pedal digit III", "nail of third toe", "nail plate of third toe", "third toe nail" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011280" ; a owl:Class ; rdfs:label "nail of pedal digit 3" ; rdfs:subClassOf obo:UBERON_0009567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0011281 obo:IAO_0000115 "A nail that is part of a pedal digit 4." ; oboInOwl:hasDbXref "EMAPA:18742", "FMA:54353", "SCTID:181595002" ; oboInOwl:hasExactSynonym "claw of digit 4 of hind-paw", "fourth toe nail", "nail of fourth toe", "nail of pedal digit IV", "nail plate of fourth toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011281" ; a owl:Class ; rdfs:label "nail of pedal digit 4" ; rdfs:subClassOf obo:UBERON_0009567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0011282 obo:IAO_0000115 "A nail that is part of a pedal digit 5." ; oboInOwl:hasDbXref "EMAPA:18743", "FMA:54356", "SCTID:181596001" ; oboInOwl:hasExactSynonym "claw of digit 5 of hind-paw", "little toe nail", "nail of fifth toe", "nail of little toe", "nail of pedal digit V", "nail plate of little toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011282" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nail of pedal digit 5" ; rdfs:subClassOf obo:UBERON_0009567 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0011289 obo:IAO_0000115 "The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis." ; oboInOwl:hasDbXref "FMA:55074", "SCTID:16675008", "Wikipedia:Pharyngobasilar_fascia" ; oboInOwl:hasExactSynonym "pharyngeal aponeurosis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pharyngeal aponeurosis" ; oboInOwl:id "UBERON:0011289" ; a owl:Class ; rdfs:label "pharyngobasilar fascia" ; rdfs:subClassOf obo:UBERON_0006614 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006614 _:genid150840 ) ] . obo:UBERON_0011298 obo:IAO_0000115 "The submucous layer of the wall of the uterine tube." ; oboInOwl:hasDbXref "BTO:0002116", "SCTID:245489008" ; oboInOwl:hasExactSynonym "submucosa of fallopian tube", "tela submucosa tubae uterinae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "submucous layer of uterine tube", "uterine submucosa" ; oboInOwl:id "UBERON:0011298" ; a owl:Class ; rdfs:label "submucosa of uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_0011299 obo:IAO_0000115 "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum." ; obo:UBPROP_0000001 "CNS white matter that is part of the telencephalon[ZFA:0000597]." ; oboInOwl:hasAlternativeId "UBERON:0013202", "UBERON:0022550" ; oboInOwl:hasDbXref "BIRNLEX:1075", "FMA:83930", "HBA:9219", "HBA:9230", "TAO:0000597", "ZFA:0000597" ; oboInOwl:hasExactSynonym "predominantly white regional part of telencephalon", "telencephalic tract/commissure", "telencephalic white matter" ; oboInOwl:hasNarrowSynonym "telencephalic tracts" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011299" ; a owl:Class ; rdfs:label "white matter of telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0011300 obo:IAO_0000115 "A portion of gray matter that is part of a telencephalon." ; oboInOwl:hasAlternativeId "UBERON:0024186" ; oboInOwl:hasDbXref "BIRNLEX:1067", "FMA:83911" ; oboInOwl:hasExactSynonym "predominantly gray regional part of telencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011300" ; a owl:Class ; rdfs:label "gray matter of telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0011306 obo:IAO_0000115 "The deep temporalis muscle is a separable part of the temporalis muscle that that attaches to the bony wall of the braincase and is deep to the superficial temporalis." ; oboInOwl:hasDbXref "MFMO:0000086" ; oboInOwl:hasExactSynonym "medial temporal", "posterior temporal", "temporal muscle posterior part", "temporalis bbHauptmassebb", "temporalis lamina profunda", "temporalis pars posterior", "temporalis pars profunda", "temporalis posterior head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011306" ; a owl:Class ; rdfs:label "deep part of temporalis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001101 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0011313 obo:UBPROP_0000001 "The posterior masseter is a separable part of the deep masseter muscle that attaches to the postero-ventral surface of the zygomatic arch.[FEED]" ; oboInOwl:hasExactSynonym "masseter, posterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011313" ; a owl:Class ; rdfs:label "posterior subdivision of masseter" ; owl:disjointWith obo:UBERON_0011314 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0011314 obo:UBPROP_0000001 "The anterior masseter is a separable part of the masseter muscle that is attached to anterior root of zygomatic arch.[FEED]" ; oboInOwl:hasExactSynonym "masseter, anterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011314" ; a owl:Class ; rdfs:label "anterior subdivision of masseter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0011318 obo:IAO_0000115 "The articular capsule (capsular ligament) is a thin, loose envelope, attached above to the circumference of the mandibular fossa and the articular tubercle immediately in front; below, to the neck of the condyle of the mandible." ; oboInOwl:hasDbXref "FMA:57050", "MFMO:0000046", "SCTID:303404000", "Wikipedia:Capsule_of_temporomandibular_joint" ; oboInOwl:hasExactSynonym "articular capsule of temporomandibular joint", "capsula articularis articulationis temporomandibularis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011318" ; a owl:Class ; rdfs:label "capsule of temporomandibular joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150896 ] . obo:UBERON_0011320 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "FMA:57070", "SCTID:127861009", "Wikipedia:Temporomandibular_joint#Ligaments" ; oboInOwl:hasExactSynonym "temporomandibular joint ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011320" ; a owl:Class ; rdfs:label "ligament of temporomandibular joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003700 ] ) ] . obo:UBERON_0011321 obo:IAO_0000115 "A muscular branch of the mandibular nerve passing to the medial surface of the masseter muscle, which it innervates." ; oboInOwl:hasDbXref "FMA:53103", "SCTID:280254006", "Wikipedia:Masseteric_nerve" ; oboInOwl:hasExactSynonym "nervus massetericus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011321" ; a owl:Class ; rdfs:label "masseteric nerve" ; rdfs:subClassOf _:genid153011 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0011322 obo:IAO_0000115 "A nerve that innervates the mylohyoid muscle and the anterior belly of the digastric muscle." ; oboInOwl:hasDbXref "BAMS:myhy", "FMA:53247", "SCTID:280269007", "Wikipedia:Mylohyoid_nerve" ; oboInOwl:hasExactSynonym "branch of inferior alveolar nerve to mylohyoid", "mylodigastric nerve", "mylohyoid branch of inferior alveolar nerve", "nerve to mylohyoid", "nervus mylohyoideus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nerve to mylohyoid" ; oboInOwl:id "UBERON:0011322" ; a owl:Class ; rdfs:label "mylohyoid nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001564 ] ) ] . obo:UBERON_0011332 oboInOwl:hasDbXref "EMAPA:17884" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011332" ; a owl:Class ; rdfs:label "extrinsic tongue pre-muscle mass" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005865 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001575 ] ) ] . obo:UBERON_0011342 obo:IAO_0000115 "An anatomical surface that is part of a mandible." ; oboInOwl:hasDbXref "FMA:57558" ; oboInOwl:hasExactSynonym "mandibular surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011342" ; a owl:Class ; rdfs:label "surface of mandible" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 _:genid150932 ) ] . obo:UBERON_0011344 oboInOwl:hasBroadSynonym "lateral surface of mandibular ramus" ; oboInOwl:hasDbXref "FMA:59463" ; oboInOwl:hasExactSynonym "lateral surface of ramus of mandible" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external surface of ramus of mandible" ; oboInOwl:id "UBERON:0011344" ; a owl:Class ; rdfs:label "lateral surface of mandible" ; rdfs:subClassOf obo:UBERON_0011342 . obo:UBERON_0011349 obo:IAO_0000115 "The pterygomandibular raphe (pterygomandibular ligament) is a tendinous band of the buccopharyngeal fascia, attached by one extremity to the hamulus of the medial pterygoid plate, and by the other to the posterior end of the mylohyoid line of the mandible. Its medial surface is covered by the mucous membrane of the mouth. Its lateral surface is separated from the ramus of the mandible by a quantity of adipose tissue. Its posterior border gives attachment to the superior pharyngeal constrictor muscle. Its anterior border attaches to the posterior edge of the buccinator." ; obo:UBPROP_0000012 "isa anatomical line in FMA" ; oboInOwl:hasDbXref "FMA:55618", "SCTID:142713007", "Wikipedia:Pterygomandibular_raphe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pterygomandibular ligament", "pterygomandibular raph%c3%a9" ; oboInOwl:id "UBERON:0011349" ; a owl:Class ; rdfs:label "pterygomandibular raphe" ; rdfs:subClassOf obo:UBERON_0002384, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] . obo:UBERON_0011362 obo:IAO_0000115 "A blood vasculature that is part of a head." ; obo:UBPROP_0000001 "Blood vessel part of cranial vasculature.[TAO]" ; oboInOwl:hasDbXref "TAO:0005297", "ZFA:0005297" ; oboInOwl:hasExactSynonym "cranial blood vessel", "set of blood vessels of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial blood vessels" ; oboInOwl:id "UBERON:0011362" ; a owl:Class ; rdfs:label "cranial blood vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004537 _:genid150946 ) ] . obo:UBERON_0011363 obo:IAO_0000115 "A lymph vasculature that is part of a head." ; oboInOwl:hasDbXref "FMA:224562", "TAO:0005298", "ZFA:0005298" ; oboInOwl:hasExactSynonym "cranial lymph vessel", "cranial lymphatics", "set of lymphatic vessels of head" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial lymph vessels", "set of cranial lymphatic vessels" ; oboInOwl:id "UBERON:0011363" ; a owl:Class ; rdfs:label "cranial lymph vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004536 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0011364 obo:IAO_0000115 "The cleidomastoideus is a thick, strap-like muscle that together with the cleidocervicalis forms the proximal part of the brachiocephalicus. It lies beneath the cleidocervicalis. Its origin is the clavicular tendon with its insertion being at the mastoid process of the temporal bone. It is distinctly narrow and is united with the cleidocervicalis and cleidobrachialis by the clavicular tendon. Together with the other two components of the brachiocephalicus muscle, its primary function is to advance the free limb, however, it can also act as an shoulder extensor. Acting bilaterally, it fixes and depresses the neck, while by its unilateral action, it allows the head and neck to be drawn to the side. Its blood supply is the inferior cervical, carotid and vertebral arteries and its nerve supply is the spinal accessory, cervical and axillary nerves." ; oboInOwl:hasDbXref "EMAPA:37687", "MA:0002275", "NCIT:C52893", "UMLS:C1707412" ; oboInOwl:hasExactSynonym "cleidocephalic", "cleidocephalic muscle", "cleidocephalicus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cleidomastoid", "cleidomastoid muscle", "cleidomastoideus", "pars mastoideus" ; oboInOwl:id "UBERON:0011364" ; a owl:Class ; rdfs:comment "alt def: \"Combination of cleidomastoid and cleidocervical muscles\"" ; rdfs:label "cleidocephalicus muscle" ; rdfs:subClassOf _:genid150968, [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001105 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011220 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011220 ] ) ] . obo:UBERON_0011366 obo:IAO_0000115 "This muscle makes up the distal segment of the brachiocephalicus. It originates at the clavicular tendon but functionally, from the head and neck through the cleidocervicalis. It inserts at the distal end of the cranial border of the humerus, where it lies between the biceps brachii medially and the brachialis laterally. The muscle partly covers the pectoral muscles at their insertions. In conjunction with the cleidocervicalis, it advances the limb, extends the shoulder and causes lateral movement of the head and neck." ; oboInOwl:hasDbXref "EMAPA:37686", "MA:0002274", "NCIT:C52892", "UMLS:C1707411" ; oboInOwl:hasExactSynonym "cleidobrachial", "cleidobrachial muscle", "cleidobrachialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011366" ; a owl:Class ; rdfs:label "cleidobrachialis muscle" ; rdfs:subClassOf _:genid150983, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000976 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011364 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ] . obo:UBERON_0011368 obo:IAO_0000115 "The brachiocephalicus is a long and flat, complex of muscles that extends from the lower half of the humeral shaft to the head and neck. The muscle divides into two parts at the clavicular intersection. This is also the point of origin for all the muscles that make up the brachiocephalicus. This point is situated just cranial to the shoulder. The two main sections are the cleidobrachialis which is distal to the clavicular intersection and the cleidocephalicus which extends proximally to the clavivular intersection. The cleidocephalicus can also be divided into the pars cervicalis, which inserts on the broad aponeurosis, over the fibrous raphe of the cranial half of the neck. The other part, the pars mastoideus inserts on the mastoid process of the temporal bone via a strong tendon. The cleidobrachialis extends distally from the clavicular intersection and inserts on the cranial edge of the distal half of the humerus. The tendon that inserts the cleidobrachialis lies between the brachialis muscle and the biceps brachii. As a result of the brachiocephalicus spanning a large region it has the ability to provide a number of actions. These include extending the shoulder joint, protracts the limb, provides lateral movement of the head and allows the neck to be depressed." ; oboInOwl:hasBroadSynonym "brachiocephalicus" ; oboInOwl:hasDbXref "EMAPA:37685" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011368" ; a owl:Class ; rdfs:comment "The brachiocephalicus is more complex than other muscles of the forelimb. It consists of 2 elements that unite at the clavicle in dogs. In dogs the caudal part, known as the cleidobrachialis, runs from the clavicle to the humerus and is closely associated with the deltoid. The cranial portion runs from the clavicle to various attachments via a broad aponeurosis on the upper part of the head and neck. It is called the cleidomastoideus in the dog because it inserts on the mastoid process of the temporal bone. It may have a different name, like cleido-occipitalis, in other mammals. The name brachiocephalicus signifies that this complex of muscles runs from the upper arm to the head and does not specify the details of muscle attachments because these vary so much from species to species. The brachiocephalicus advances the limb and may also extend the shoulder joint, but this depends on the cranial attachment being fixed and the limb being free to move. However, when the forelimb is firmly on the ground and the head is free to move, it forces the head and neck either ventrally or to one side depending on whether or not both muscles act in tandem" ; rdfs:label "brachiocephalic muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid150990 ] . obo:UBERON_0011370 obo:IAO_0000115 "A transverse process of vertebra that is part of a vertebral bone 1." ; oboInOwl:hasDbXref "FMA:23981", "SCTID:181895009", "Wikipedia:Transverse_processes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011370" ; a owl:Class ; rdfs:label "transverse process of atlas" ; rdfs:subClassOf _:genid153101 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001092 ] ) ] . obo:UBERON_0011371 obo:IAO_0000115 "The sternocephalicus is a flat muscle and its caudal border is adjacent to the ventral border of the brachiocephalicus. The lateral aspect of this muscle is crossed obliquely by the external jugular vein. It originates as a unit on the first sternebrae. The cranial portion of the muscle divides into two separate sections with different insertion points. These are the sternomastoideus and the sterno-occipitalis. The ventral portion, the sternomastiodeus is the stronger and main continuation of the sternocephalicus, which inserts on the mastoid part of the temporal bone. The thin but wide dorsal segment, the sterno-occipitalis attaches to the dorsal nuchal crest by a thin aponeurosis. The main action provided by the sternocephalicus is movement of the head and neck to the side. Ventral branches of the cervical nerves are attached to this muscle." ; oboInOwl:hasDbXref "NCIT:C117980", "SCTID:21636001" ; oboInOwl:hasExactSynonym "sternocephalicus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011371" ; a owl:Class ; rdfs:label "sternocephalicus muscle" ; rdfs:subClassOf _:genid153112 ; owl:equivalentClass _:genid151003 . obo:UBERON_0011374 obo:IAO_0000115 "A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present." ; obo:IAO_0000232 "this is a generic sex-neutral grouping class for the male and female prepuce. Note that this structure is a combination of skin and other tissue" ; obo:UBPROP_0000007 "preputial" ; oboInOwl:hasDbXref "NCIT:C12323" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011374" ; a owl:Class ; rdfs:label "prepuce" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003133 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000014 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000344 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0035004 ] . obo:UBERON_0011375 obo:IAO_0000115 "A zone of skin that is part of a prepuce of clitoris." ; oboInOwl:hasDbXref "FMA:27886", "SCTID:367670008" ; oboInOwl:hasExactSynonym "preputial skin of clitoris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011375" ; a owl:Class ; rdfs:label "skin of prepuce of clitoris" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005298 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005299 ] ) ] . obo:UBERON_0011379 obo:IAO_0000115 "The external sphincter muscle of urethra (or sphincter urethrae membranaceae) surrounds the whole length of the membranous portion of the urethra, and is enclosed in the fasciæ of the urogenital diaphragm. They arch across the front of the urethra and bulbourethral glands, pass around the urethra, and behind it unite with the muscle of the opposite side, by means of a tendinous raphé." ; obo:UBPROP_0000012 "MA includes a term bulboglandular - some sources claim this as the muscles that are associated with the bulbourethral gland, so we place this here" ; oboInOwl:hasDbXref "FMA:19733", "MA:0002273", "NCIT:C52891", "UMLS:C1707060", "Wikipedia:External_sphincter_muscle_of_male_urethra" ; oboInOwl:hasExactSynonym "external urethral sphincter of male urethra", "male sphincter urethrae", "male sphincter urethrae muscle", "male urethral sphincter muscle", "musculus sphincter urethrae externus (urethra masculina)", "musculus sphincter urethrae externus urethrae masculinae", "musculus sphincter urethrae membranaceae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bulboglandular", "bulboglandular muscle" ; oboInOwl:id "UBERON:0011379" ; a owl:Class ; rdfs:label "male external urethral sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004919 _:genid151027 ) ] . obo:UBERON_0011380 obo:IAO_0000115 "The external sphincter muscle of female urethra is a muscle which controls urination." ; oboInOwl:hasDbXref "FMA:19778", "Wikipedia:External_sphincter_muscle_of_female_urethra" ; oboInOwl:hasExactSynonym "external urethral sphincter of female urethra", "musculus sphincter urethrae externus (urethra feminina)", "musculus sphincter urethrae externus urethrae femininae", "outer muscle layer of female urethra", "rhabdosphincter of female urethra", "striated muscle layer of female urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "compressor urethrae", "sphincter urethrovaginalis", "urethrovaginal sphincter" ; oboInOwl:id "UBERON:0011380" ; a owl:Class ; rdfs:label "female external urethral sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004919 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0011386 obo:IAO_0000115 "A chiasma of facial muscles held together by fibrous tissue, located lateral and slightly superior to each angle of the mouth. It is important in moving the mouth, facial expression and in dentistry. It derives its motor nerve supply from the facial nerve, and its blood supply from labial branches of the facial artery. It is contributed to by the following muscles: orbicularis oris, buccinator, levator anguli oris, depressor anguli oris, zygomaticus major, risorius quadratus labii superioris, quadratus labii inferioris." ; oboInOwl:hasBroadSynonym "modiolus" ; oboInOwl:hasDbXref "FMA:46837", "MFMO:0000057", "Wikipedia:Modiolus_(face)" ; oboInOwl:hasExactSynonym "modiolus anguli oris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011386" ; a owl:Class ; rdfs:label "facial modiolus" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/471"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0002385, _:genid153155 . obo:UBERON_0011390 obo:IAO_0000115 "The pudendal nerve is a somatic nerve in the pelvic region that innervates the external genitalia of both sexes, as well as sphincters for the bladder and the rectum. It originates in Onuf's nucleus in the sacral region of the spinal cord." ; oboInOwl:hasBroadSynonym "pudendal" ; oboInOwl:hasDbXref "FMA:19037", "MESH:D060525", "SCTID:181057000", "Wikipedia:Pudendal_nerve" ; oboInOwl:hasExactSynonym "nervus pudendae", "nervus pudendales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal pudendal nerve", "pudenal nerve" ; oboInOwl:id "UBERON:0011390" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pudendal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000012 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004176 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004919 ] ) ] . obo:UBERON_0011391 obo:IAO_0000115 "A nerve arising from the pudendal nerve that supplies the perineum." ; oboInOwl:hasDbXref "FMA:21866", "SCTID:303236009", "Wikipedia:Perineal_nerve" ; oboInOwl:hasExactSynonym "perineal branch of pudendal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011391" ; a owl:Class ; rdfs:label "perineal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0011390 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002356 ] ) ] . obo:UBERON_0011565 oboInOwl:hasDbXref "FMA:54364", "SCTID:432899004" ; oboInOwl:hasExactSynonym "cavity of digestive tract", "cavity of gastrointestinal tract", "gastrointestinal tract lumen", "lumen of gastrointestinal tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011565" ; a owl:Class ; rdfs:label "lumen of gastrointestinal system" ; rdfs:subClassOf obo:UBERON_0002553, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ] . obo:UBERON_0011566 obo:IAO_0000115 "An anatomical cavity that is part of a esophagus." ; oboInOwl:hasDbXref "EMAPA:18380", "FMA:9398", "SCTID:322648002" ; oboInOwl:hasExactSynonym "cavity of eosophagus", "cavity of esophagus", "eosophageal cavity", "eosophageal lumen", "eosophagus lumen", "esophageal cavity", "esophageal lumen", "esophagus lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011566" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lumen of esophagus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ], _:genid153191 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0011574 obo:IAO_0000115 "A tube lumen that is part of a mesonephric duct." ; oboInOwl:hasDbXref "EHDAA2:0001244" ; oboInOwl:hasExactSynonym "nephric duct lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cavity of nephric duct" ; oboInOwl:id "UBERON:0011574" ; a owl:Class ; rdfs:label "mesonephric duct lumen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005082 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003074 ] ) ] . obo:UBERON_0011575 obo:IAO_0000115 "The styloid process of the ulna projects from the medial and back part of the bone; it descends a little lower than the head, and its rounded end affords attachment to the ulnar collateral ligament of the wrist[WP,unvetted]." ; oboInOwl:hasDbXref "FMA:23628", "SCTID:181952009", "Wikipedia:Ulnar_styloid_process" ; oboInOwl:hasExactSynonym "processus styloideus ulnae", "ulnar styloid process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011575" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "styloid process of ulna" ; rdfs:subClassOf obo:UBERON_0004529, _:genid153205 . obo:UBERON_0011576 obo:IAO_0000115 "The superior half of the orbital rim, which constitutes the curved superior border of the orbital opening, formed by the frontal bone." ; obo:UBPROP_0000008 "Neanderthals have a Supraorbital torus, a prominent, trabecular (spongy) brow ridge." ; obo:UBPROP_0000012 "see also: 'supraorbital flange'. FMA has 2 related classes, but these refer to the line and surface" ; oboInOwl:hasDbXref "FMA:317104", "NCIT:C82953", "SCTID:280550003", "UMLS:C2826587", "Wikipedia:Supraorbital_ridge" ; oboInOwl:hasExactSynonym "margo supraorbitalis", "superior orbital rim", "supra-orbital margin", "supra-orbital ridge", "supraorbital margin" ; oboInOwl:hasNarrowSynonym "frontal torus", "supraorbital torus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arcus superciliaris", "eyebrow bone", "frontal torus", "margin of the orbit", "margo supraorbitalis (os frontale)", "orbital ridge", "superciliary ridge", "supra-orbital border of frontal bone", "supra-orbital margin of frontal bone", "supraorbital arch", "supraorbital margin", "supraorbital margin of frontal bone", "supraorbital surface of frontal bone", "supraorbital torus" ; oboInOwl:id "UBERON:0011576" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "supraorbital ridge" ; rdfs:seeAlso obo:FMA_53097, obo:FMA_57137 ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000209 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035849 ] . obo:UBERON_0011582 obo:IAO_0000115 "The collection of all skeletal elements in an individual limb or fin." ; obo:UBPROP_0000001 "Skeletal subdivision that is part of the paired limb/fin.[VSAO]" ; oboInOwl:hasDbXref "VSAO:0000301" ; oboInOwl:hasExactSynonym "limb/fin skeleton", "skeletal parts of limb/fin", "skeleton of limb/fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011582" ; oboInOwl:inSubset core:homology_grouping ; a owl:Class ; rdfs:label "paired limb/fin skeleton" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004708 ], _:genid153239 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0004708 ] ) ] . obo:UBERON_0011583 obo:IAO_0000115 "Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]." ; obo:UBPROP_0000001 "Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO]" ; obo:UBPROP_0000007 "propodial", "stylopodial" ; oboInOwl:hasDbXref "VSAO:0005007" ; oboInOwl:hasExactSynonym "stylopodium skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mesomere 1", "propodial skeleton", "propodium", "proximal metapterygial mesomere", "stylopod", "stylopodium" ; oboInOwl:id "UBERON:0011583" ; a owl:Class ; rdfs:label "stylopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002472 ], _:genid153249 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002472 ] ) ] . obo:UBERON_0011584 obo:IAO_0000115 "Section of the forelimb skeleton located between the stylopodium and the autopodium." ; obo:UBPROP_0000007 "zeugopodial", "zygopodial" ; oboInOwl:hasDbXref "VSAO:0005010" ; oboInOwl:hasExactSynonym "epipodial skeleton", "skeleton of zeugopod", "zeugopod skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epipodium", "mesomere 2", "mesomere 2 skeleton", "zygopodium" ; oboInOwl:id "UBERON:0011584" ; a owl:Class ; rdfs:label "zeugopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002471 ], [ a owl:Restriction ; owl:onProperty core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0011583 ], _:genid153262 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002471 ] ) ] . obo:UBERON_0011585 obo:IAO_0000115 "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." ; obo:IAO_0000116 "consider obsoleting, coordinate with VSAO" ; oboInOwl:hasDbXref "VSAO:0000006", "XAO:0004021" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011585" ; a owl:Class ; rdfs:label "cell condensation" ; rdfs:subClassOf obo:UBERON_0000061 . obo:UBERON_0011587 obo:IAO_0000115 "Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix." ; oboInOwl:hasDbXref "EMAPA:36439", "VSAO:0000071", "XAO:0004052" ; oboInOwl:hasExactSynonym "pre-dentine tissue", "predentin", "predentine tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011587" ; a owl:Class ; rdfs:label "pre-dentine" ; rdfs:subClassOf obo:UBERON_0010365, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ], _:genid153276, _:genid153278 . obo:UBERON_0011588 obo:IAO_0000115 "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." ; oboInOwl:hasDbXref "VSAO:0000066", "XAO:0004202" ; oboInOwl:hasExactSynonym "pre-enamel tissue", "preenamel tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011588" ; a owl:Class ; rdfs:label "pre-enamel" ; rdfs:subClassOf obo:UBERON_0010365, [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:CL_0000059 ] . obo:UBERON_0011589 obo:IAO_0000115 "Cartilage tissue that is not mineralized." ; obo:IAO_0000116 "add developmental relationships; add disjointness axiom" ; oboInOwl:hasDbXref "VSAO:0000089", "XAO:0004044" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011589" ; a owl:Class ; rdfs:label "non-mineralized cartilage tissue" ; rdfs:subClassOf obo:UBERON_0002418 . obo:UBERON_0011590 obo:IAO_0000115 "A commissure that is part of a diencephalon." ; oboInOwl:hasDbXref "FMA:62445" ; oboInOwl:hasExactSynonym "diencephalon commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011590" ; a owl:Class ; rdfs:label "commissure of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0011591 obo:IAO_0000115 "An axon tract that is part of a diencephalon." ; oboInOwl:hasDbXref "FMA:62447" ; oboInOwl:hasExactSynonym "diencephalon tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011591" ; a owl:Class ; rdfs:label "tract of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0011592 oboInOwl:hasDbXref "EHDAA2:0002120" ; oboInOwl:hasExactSynonym "upper jaw future lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011592" ; a owl:Class ; rdfs:label "future upper lip" ; rdfs:subClassOf obo:UBERON_0000490, _:genid153304, _:genid153306, _:genid153308 . obo:UBERON_0011593 obo:IAO_0000115 "A tooth that is attached to a maxilla[TAO,modified]." ; obo:IAO_0000232 "this ontology also contains a class for 'tooth of upper jaw'. This is not equivalent to 'maxillary tooth' in a multi-species context, because many vertebrates have other tooth-bearing bones in the upper jaw[http://orcid.org/0000-0002-6601-2165]" ; obo:UBPROP_0000001 "Tooth that is attached to the maxilla.[TAO]" ; oboInOwl:hasDbXref "AAO:0000287", "FMA:321646", "SCTID:422279005", "TAO:0001627", "Wikipedia:Tooth_(human)" ; oboInOwl:hasExactSynonym "maxillary teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011593" ; a owl:Class ; rdfs:label "maxillary tooth" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009680 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_0011594 obo:IAO_0000115 "Tooth that is attached to a dentary/mandible[TAO,modified]." ; obo:IAO_0000116 "Note that we treat dentary tooth and mandibular tooth as equivalent" ; obo:UBPROP_0000001 "Tooth that is attached to the dentary.[TAO]" ; obo:UBPROP_0000002 "relationship loss: part_of dentary tooth row (TAO:0001952)[TAO]" ; oboInOwl:hasDbXref "AAO:0000125", "AAO:0000641", "FMA:321647", "SCTID:245547003", "TAO:0001628" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mandibular teeth", "mandibular tooth", "tooth of dentary" ; oboInOwl:id "UBERON:0011594" ; a owl:Class ; rdfs:label "dentary tooth" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009679 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004742 ] ) ] . obo:UBERON_0011595 obo:IAO_0000115 "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." ; oboInOwl:hasDbXref "EMAPA:32905", "NCIT:C114916" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011595" ; a owl:Class ; rdfs:label "jaw region" ; rdfs:seeAlso "http://eol.org/collections/11578"^^xsd:anyURI ; rdfs:subClassOf _:genid153332 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001708 ] ) ] . obo:UBERON_0011596 oboInOwl:hasDbXref "EHDAA2:0001020" ; oboInOwl:hasExactSynonym "lower jaw future lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011596" ; a owl:Class ; rdfs:label "future lower lip" ; rdfs:subClassOf obo:UBERON_0000490, _:genid153336, _:genid153338 . obo:UBERON_0011597 obo:IAO_0000115 "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species)." ; obo:IAO_0000116 "Do not manually classify under here - bones are automatically classified" ; oboInOwl:hasExactSynonym "upper jaw bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011597" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "bone of upper jaw" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0011601 obo:IAO_0000115 "A gingiva that is part of a upper jaw region." ; oboInOwl:hasDbXref "EMAPA:18970", "FMA:59763", "NCIT:C54205", "SCTID:304703001", "UMLS:C0227121" ; oboInOwl:hasExactSynonym "gum of maxilla", "gum of upper jaw", "upper gingiva", "upper jaw gingiva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "maxillary gum", "upper gum" ; oboInOwl:id "UBERON:0011601" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gingiva of upper jaw" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001828 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0011602 obo:IAO_0000115 "A gingiva that is part of a lower jaw region." ; oboInOwl:hasDbXref "EMAPA:18967", "FMA:59764", "NCIT:C54204", "SCTID:304704007", "UMLS:C0227123" ; oboInOwl:hasExactSynonym "gum of lower jaw", "gum of mandible", "lower gingiva", "lower jaw gingiva" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lower gum", "lower jaw gum", "mandibular gum" ; oboInOwl:id "UBERON:0011602" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gingiva of lower jaw" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001828 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0011606 obo:IAO_0000115 "Replacement bone that is bilaterally paired and (in teleosts) articulates with the neurocranium dorsally and the opercle posteriorly[TAO,modified]." ; obo:UBPROP_0000001 "Replacement bone that is bilaterally paired and articulates with the neurocranium dorsally and the opercle posteriorly.[TAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps hyomandibula-metapterygoid joint (TAO:0001979)[TAO]", "relationship loss: overlaps hyomandibula-opercle joint (TAO:0005265)[TAO]", "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]", "relationship loss: overlaps preopercle vertical limb-hyomandibula joint (TAO:0005278)[TAO]", "relationship loss: overlaps quadrate-hyomandibula joint (TAO:0001801)[TAO]" ; obo:UBPROP_0000003 "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" ; obo:UBPROP_0000008 "In most teleosts, there is a symplectic, and the hyomandibula articulates with it anteroventrally." ; oboInOwl:hasBroadSynonym "hyomandibula", "hyomandibular" ; oboInOwl:hasDbXref "EFO:0003556", "TAO:0000672", "VHOG:0000688", "Wikipedia:Hyomandibula", "ZFA:0000672" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011606" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "hyomandibular bone" ; rdfs:subClassOf obo:UBERON_0002513, _:genid153369 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011608 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0011607 obo:IAO_0000115 "Cartilage form of the hyomandibular element." ; obo:UBPROP_0000001 "Pharyngeal arch cartilage that is bilaterally paired and articulates with the chondrocranium dorsally, the opercle bone posteriorly, and the palatoquadrate cartilage anteriorly.[TAO]" ; obo:UBPROP_0000003 "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" ; obo:UBPROP_0000008 "The stapes is homologous to the hyomandibula. In this ontology, we use the class 'hyomandibular cartilage' generally to include the future stapes, the future hyomandibular bone of teleosts and the unossified cartilage in sharks." ; oboInOwl:hasDbXref "EFO:0003686", "TAO:0001422", "VHOG:0000688", "ZFA:0001422" ; oboInOwl:hasExactSynonym "hyosymplectic cartilage", "symplectic cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011607" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "hyomandibular cartilage" ; rdfs:subClassOf obo:UBERON_0011004 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011608 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0011608 obo:IAO_0000115 "The upper paired deep bone or cartilage of the hyoid region, sometimes taking part in jaw suspension and which supports the opercle. Dorsally it articulates with the otic capsule at the hyomandibular fossa, ventrally with the quadrate and symplectic. In most Teleostei it has a foramen for the hyomandibular branch of the facial nerve (VII)." ; obo:UBPROP_0000001 "Replacement bone that is bilaterally paired and articulates with the neurocranium dorsally and the opercle posteriorly.[TAO]" ; obo:UBPROP_0000002 "relationship loss: overlaps hyomandibula-metapterygoid joint (TAO:0001979)[TAO]", "relationship loss: overlaps hyomandibula-opercle joint (TAO:0005265)[TAO]", "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]", "relationship loss: overlaps preopercle vertical limb-hyomandibula joint (TAO:0005278)[TAO]", "relationship loss: overlaps quadrate-hyomandibula joint (TAO:0001801)[TAO]" ; obo:UBPROP_0000003 "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" ; obo:UBPROP_0000005 "In most teleosts, there is a symplectic, and the hyomandibula articulates with it anteroventrally.[TAO]" ; oboInOwl:hasDbXref "TAO:0000672", "VHOG:0000688" ; oboInOwl:hasExactSynonym "hyomandibula - stapes", "hyomandibula element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epihyal", "hyomandibula" ; oboInOwl:id "UBERON:0011608" ; a owl:Class ; rdfs:label "hyomandibular element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011152 ] . obo:UBERON_0011628 oboInOwl:hasDbXref "EHDAA2:0001495" ; oboInOwl:hasExactSynonym "future premaxilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011628" ; a owl:Class ; rdfs:label "early premaxilla" ; rdfs:subClassOf obo:UBERON_0007842, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid153405, _:genid153407, _:genid153409 . obo:UBERON_0011641 obo:IAO_0000115 "An odontogenic papilla that is part of a molar tooth [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32881", "MA:0003230" ; oboInOwl:hasExactSynonym "molar mesenchyme", "odontogenic mesenchyme of molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011641" ; a owl:Class ; rdfs:label "odontogenic mesenchyme of molar" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0011642 obo:IAO_0000115 "An epithelium that develops_from a ectoderm and is part of a oral epithelium." ; oboInOwl:hasDbXref "EHDAA2:0004137" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011642" ; a owl:Class ; rdfs:label "oral epithelium from ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, _:genid153425 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002424 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0011645 obo:IAO_0000115 "Limb extensor that runs from ilium to femur." ; oboInOwl:hasExactSynonym "iliofemoralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011645" ; a owl:Class ; rdfs:label "iliofemoralis muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001325 [ a owl:Restriction ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001273 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000981 ] ) ] . obo:UBERON_0011648 oboInOwl:hasDbXref "AAO:0000247", "EFO:0003511", "TAO:0000236", "XAO:0003269", "ZFA:0000236" ; oboInOwl:hasExactSynonym "mandibular muscle", "mandibular muscles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011648" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "jaw muscle" ; rdfs:subClassOf obo:UBERON_0002376, [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071626 ] . obo:UBERON_0011676 obo:IAO_0000115 "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." ; obo:IAO_0000116 "Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem" ; oboInOwl:hasExactSynonym "axial subdivision of organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body segment", "main body segment" ; oboInOwl:id "UBERON:0011676" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "subdivision of organism along main body axis" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013701 ] . obo:UBERON_0011677 obo:IAO_0000115 "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly." ; obo:UBPROP_0000202 obo:FMA_72066 ; oboInOwl:hasExactSynonym "thoracolumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "presacral vertebra" ; oboInOwl:id "UBERON:0011677" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "trunk vertebra" ; rdfs:subClassOf obo:UBERON_0004451 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009568 ] ) ] . obo:UBERON_0011678 obo:IAO_0000115 "A proximal tarsal bone that articulates with the fibula." ; obo:UBPROP_0000008 "The amphibian intermedium forms part of the astragalus in amniotes[http://www.science.marshall.edu/okeefef/PDFS/OKeefe_et_al_2006_JMorph.pdf]" ; oboInOwl:hasBroadSynonym "intermedium" ; oboInOwl:hasDbXref "AAO:0000923" ; oboInOwl:hasExactSynonym "hidlimb intermedium", "intermedium (hind)", "intermedium of pes", "pedal intermedium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011678" ; a owl:Class ; rdfs:label "hindlimb intermedium bone" ; rdfs:subClassOf obo:UBERON_0011679 . obo:UBERON_0011679 obo:IAO_0000115 "A tarsal bone that connected_to a hindlimb zeugopod skeleton." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011679" ; a owl:Class ; rdfs:label "proximal tarsal bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015082 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015081 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0011695 obo:IAO_0000115 "A cardiovascular system that is part of a conceptus." ; oboInOwl:hasDbXref "EHDAA2:0000216", "FMA:305965", "NCIT:C34148" ; oboInOwl:hasExactSynonym "conceptus cardiovascular system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic circulatory system", "fetal circulatory system" ; oboInOwl:id "UBERON:0011695" ; a owl:Class ; rdfs:label "embryonic cardiovascular system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004535 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004716 ] ) ] . obo:UBERON_0011741 oboInOwl:hasDbXref "EMAPA:35903", "MA:0003179" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "valve leaflet" ; oboInOwl:id "UBERON:0011741" ; a owl:Class ; rdfs:label "cardiac valve leaflet" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000946 ] . obo:UBERON_0011742 obo:IAO_0000115 "A cardiac valve leaflet that is part of a aortic valve." ; obo:UBPROP_0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18627", "VHOG:0000819" ; oboInOwl:hasExactSynonym "aortic valve leaflets" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011742" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aortic valve leaflet" ; rdfs:subClassOf _:genid153469 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011741 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002137 ] ) ] . obo:UBERON_0011745 obo:IAO_0000115 "A cardiac valve leaflet that is part of a pulmonary valve." ; obo:UBPROP_0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" ; oboInOwl:hasDbXref "EMAPA:18629", "VHOG:0000820" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011745" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary valve leaflets" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011741 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002146 ] ) ] . obo:UBERON_0011754 obo:IAO_0000115 "Paired structures in the embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. In both males and females the two swellings merge: in the female, they become the posterior labial commissure; In the male, they become the scrotum." ; obo:IAO_0000116 "todo - add parthood relationships to tubercles" ; oboInOwl:hasDbXref "EMAPA:30074", "EMAPA:35377", "VHOG:0000976", "Wikipedia:Labioscrotal_swelling" ; oboInOwl:hasExactSynonym "labioscrotal swelling" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tuberculum labioscrotale" ; oboInOwl:id "UBERON:0011754" ; a owl:Class ; rdfs:label "genital swelling" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005876 ] . obo:UBERON_0011755 obo:IAO_0000115 "A genital swelling that is part of a female reproductive system." ; oboInOwl:hasBroadSynonym "labial swelling" ; oboInOwl:hasDbXref "EHDAA2:0000501", "EHDAA:9363", "EMAPA:18329", "EMAPA:30423" ; oboInOwl:hasExactSynonym "labioscrotal swelling of female" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labial primordium" ; oboInOwl:id "UBERON:0011755" ; a owl:Class ; rdfs:label "female labial swelling" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006233 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0011756 obo:IAO_0000115 "A genital swelling that is part of a male reproductive organ." ; oboInOwl:hasDbXref "EHDAA2:0001049", "EMAPA:30509" ; oboInOwl:hasExactSynonym "labioscrotal swelling of male", "scrotal bulge", "scrotal primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011756" ; a owl:Class ; rdfs:label "male genital swelling" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006261 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003135 ] ) ] . obo:UBERON_0011757 obo:IAO_0000115 "." ; oboInOwl:hasDbXref "NCIT:C34274", "UMLS:C1514448", "Wikipedia:Primordial_phallus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "phallus", "phallus primordialis", "primordial phallus" ; oboInOwl:id "UBERON:0011757" ; a owl:Class ; rdfs:label "differentiated genital tubercle" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004176 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005876 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006233 obo:UBERON_0006261 ) ] . obo:UBERON_0011766 obo:UBPROP_0000008 "The left nerve is longer than the right, because it crosses under the arch of the aorta at the ligamentum arteriosum.[WP]" ; oboInOwl:hasDbXref "EMAPA:25350", "FMA:14469", "MA:0001107", "SCTID:280300006" ; oboInOwl:hasExactSynonym "left recurrent laryngeal branch", "left recurrent laryngeal nerve", "vagus X nerve left recurrent laryngeal branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011766" ; a owl:Class ; rdfs:label "left recurrent laryngeal nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003716 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/64/Recurrent_laryngeal_nerve.svg"^^xsd:anyURI . obo:UBERON_0011767 oboInOwl:hasDbXref "EMAPA:17275", "FMA:14468", "MA:0001108", "SCTID:280299003" ; oboInOwl:hasExactSynonym "right recurrent laryngeal branch", "right recurrent laryngeal nerve", "vagus X nerve right recurrent laryngeal branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011767" ; a owl:Class ; rdfs:label "right recurrent laryngeal nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003716 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0011769 obo:IAO_0000115 "Anatomical projection that is composed of cartilage tissue." ; oboInOwl:hasDbXref "FMA:284626" ; oboInOwl:hasExactSynonym "cartilage process", "cartilaginous process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011769" ; a owl:Class ; rdfs:label "cartilaginous projection" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004529 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0011772 obo:IAO_0000115 "An anatomical space that is part of a bone of lower jaw." ; oboInOwl:hasDbXref "AAO:0000273" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011772" ; a owl:Class ; rdfs:label "lower jaw opening" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004768 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0004768 ] ) ] . obo:UBERON_0011773 obo:IAO_0000115 "An anatomical space that is part of a bone of upper jaw." ; oboInOwl:hasDbXref "AAO:0000621" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011773" ; a owl:Class ; rdfs:label "upper jaw opening" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011597 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0011597 ] ) ] . obo:UBERON_0011775 obo:IAO_0000115 "A cranial nerve nucleus that is associated with a vagus nerve." ; oboInOwl:hasDbXref "FMA:54573", "SCTID:362467005" ; oboInOwl:hasExactSynonym "nucleus of Xth nerve", "nucleus of vagal X nerve", "nucleus of vagal nerve", "nucleus of vagus nerve", "tenth cranial nerve nucleus", "vagal X nucleus", "vagal nucleus", "vagus nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nodosal nucleus" ; oboInOwl:id "UBERON:0011775" ; a owl:Class ; rdfs:label "vagus nerve nucleus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000126 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001759 ] ) ] . obo:UBERON_0011777 obo:IAO_0000115 "A neural nucleus that is part of the spinal cord." ; oboInOwl:hasDbXref "FMA:77011" ; oboInOwl:hasExactSynonym "spinal cord nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011777" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "nucleus of spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0011779 obo:IAO_0000115 "A nerve that is part of a head." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cephalic nerve", "head nerve" ; oboInOwl:id "UBERON:0011779" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "nerve of head region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0011814 obo:IAO_0000115 "Ectodermal placode that does not develop into a component of the nervous system." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011814" ; a owl:Class ; rdfs:label "non-neurogenic ectodermal placode" ; rdfs:subClassOf obo:UBERON_0005085 . obo:UBERON_0011817 obo:IAO_0000115 "An ectodermal placode that gives rise to any of the cutaneous appendages that protrude from the skin epidermis (heair, feathers, epidermal scales)." ; oboInOwl:hasExactSynonym "cutaneous appendage follicle placode", "skin follicle placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011817" ; a owl:Class ; rdfs:label "skin appendage placode" ; rdfs:subClassOf obo:UBERON_0011814, [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0001003 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002067 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005085 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0036150 ] ) ] . obo:UBERON_0011818 obo:IAO_0000115 "Superficial fascia is found in the subcutis in most regions of the body, blending with the reticular layer of the dermis. It is present on the face, over the upper portion of the sternocleidomastoid, at the nape of the neck, and overlying the sternum. It is comprised mainly of loose areolar connective tissue and adipose and is the layer that primarily determines the shape of a body. In addition to its subcutaneous presence, this type of fascia surrounds organs and glands, neurovascular bundles, and is found at many other locations where it fills otherwise unoccupied space. It serves as a storage medium of fat and water; as a passageway for lymph, nerve and blood vessels; and as a protective padding to cushion and insulate. Superficial fascia is present, but does not contain fat, in the eyelids, ear, scrotum, penis and clitoris." ; obo:UBPROP_0000012 "we follow FMA, BTO, NCIT and WP in making this a distinct class from hypodermis." ; oboInOwl:hasDbXref "BTO:0004525", "FMA:9630", "GAID:929", "MESH:D040521", "NCIT:C33660", "SCTID:361713003", "Wikipedia:Superficial_fascia" ; oboInOwl:hasExactSynonym "subcutaneous tissue", "superficial fascial layer", "tela subcutanea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011818" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "superficial fascia" ; rdfs:subClassOf obo:UBERON_0000479, _:genid153573 . obo:UBERON_0011819 obo:IAO_0000115 "A tube lumen that is part of a atrioventricular canal." ; oboInOwl:hasDbXref "EHDAA2:0000152" ; oboInOwl:hasExactSynonym "AVC lumen", "cavity of atrioventricular canal", "lumen of AVC" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011819" ; a owl:Class ; rdfs:label "lumen of atrioventricular canal" ; rdfs:subClassOf obo:UBERON_0005082, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002087 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002087 ] ) ] . obo:UBERON_0011820 obo:IAO_0000115 "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." ; oboInOwl:hasDbXref "EHDAA2:0004149", "FMA:85125" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "AV region", "AV segment", "atrial ventricular junction", "atrioventricular junction", "atrioventricular segment" ; oboInOwl:id "UBERON:0011820" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "atrioventricular region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002081 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002082 ] ) ] . obo:UBERON_0011821 obo:IAO_0000115 "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." ; oboInOwl:hasDbXref "FMA:20107" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011821" ; a owl:Class ; rdfs:label "irregular connective tissue" ; rdfs:subClassOf obo:UBERON_0002384 . obo:UBERON_0011822 obo:IAO_0000115 "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." ; obo:UBPROP_0000001 "Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT]" ; oboInOwl:hasDbXref "FMA:20109", "NCIT:C32882", "UMLS:C0738366", "Wikipedia:Dense_irregular_connective_tissue" ; oboInOwl:hasExactSynonym "irregular dense connective tissue", "typus irregularis (textus connectivus collagenosus compactus)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011822" ; a owl:Class ; rdfs:label "dense irregular connective tissue" ; rdfs:subClassOf obo:UBERON_0011821, obo:UBERON_0011823 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011860 ] ) ] . obo:UBERON_0011823 obo:IAO_0000115 "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets." ; obo:IAO_0000116 "our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid." ; obo:UBPROP_0000001 "Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT]" ; oboInOwl:hasDbXref "AAO:0000121", "NCIT:C32450", "UMLS:C1511770", "Wikipedia:Dense_connective_tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011823" ; a owl:Class ; rdfs:label "dense connective tissue" ; owl:disjointWith obo:UBERON_0011825 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011860 ] ) ] . obo:UBERON_0011824 oboInOwl:hasDbXref "FMA:75634", "SCTID:363130003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011824" ; a owl:Class ; rdfs:label "fibrous connective tissue" ; rdfs:subClassOf obo:UBERON_0011822 . obo:UBERON_0011825 obo:IAO_0000115 "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." ; oboInOwl:hasDbXref "FMA:19783", "NCIT:C33007", "UMLS:C1253917", "Wikipedia:Loose_connective_tissue" ; oboInOwl:hasExactSynonym "textus connectivus collagenosus laxus", "textus connectivus laxus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011825" ; a owl:Class ; rdfs:label "loose connective tissue" ; rdfs:subClassOf obo:UBERON_0011821 . obo:UBERON_0011827 obo:IAO_0000115 "A sebaceous glands in the areola surrounding the nipple." ; obo:UBPROP_0000001 "Lobular organ the parenchyma of which consists of acini connected to the surface of the areola or to a lactiferous duct by the duct of areolar gland. Examples: There are variable numbers of areolar glands[FMA:58090]." ; oboInOwl:hasDbXref "EMAPA:37668", "FMA:58090", "MA:0000794", "NCIT:C92833", "SCTID:279034002", "UMLS:C0929386", "Wikipedia:Areolar_glands" ; oboInOwl:hasExactSynonym "Montgomery's gland", "accessory gland of Montgomery", "accessory gland of breast", "gland of Montgomery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "mammary gland sebaceous gland" ; oboInOwl:id "UBERON:0011827" ; a owl:Class ; rdfs:label "areolar gland" ; rdfs:seeAlso "https://sourceforge.net/p/obo/mouse-anatomy-requests/80/"^^xsd:anyURI ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002032 ] ) ] . obo:UBERON_0011845 obo:IAO_0000115 "A duct that is part of a sebaceous gland." ; oboInOwl:hasDbXref "FMA:70947", "NCIT:C33520" ; oboInOwl:hasExactSynonym "sebaceous gland duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011845" ; a owl:Class ; rdfs:label "duct of sebaceous gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:UBERON_0011846 obo:IAO_0000115 "An acinus that is part of a sebaceous gland." ; oboInOwl:hasDbXref "FMA:59657" ; oboInOwl:hasExactSynonym "sebaceous gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011846" ; a owl:Class ; rdfs:label "acinus of sebaceous gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001821 ] ) ] . obo:UBERON_0011847 obo:IAO_0000115 "An acinus that is part of a parotid gland." ; oboInOwl:hasDbXref "EMAPA:37933", "FMA:59863", "SCTID:46926004" ; oboInOwl:hasExactSynonym "parotid gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011847" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "acinus of parotid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0011850 obo:IAO_0000115 "An acinus that is part of a salivary gland." ; oboInOwl:hasDbXref "FMA:59870" ; oboInOwl:hasExactSynonym "salivary gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011850" ; a owl:Class ; rdfs:label "acinus of salivary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0011854 obo:IAO_0000115 "An acinus that is part of a areolar gland." ; oboInOwl:hasDbXref "FMA:62081" ; oboInOwl:hasExactSynonym "areolar gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011854" ; a owl:Class ; rdfs:label "acinus of areolar gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011827 ] ) ] . obo:UBERON_0011856 obo:IAO_0000115 "An acinus that is part of a mammary gland." ; oboInOwl:hasDbXref "FMA:74438" ; oboInOwl:hasExactSynonym "lactiferous gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011856" ; a owl:Class ; rdfs:label "acinus of lactiferous gland" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001912 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0011857 obo:IAO_0000115 "An acinus that is part of a lacrimal gland." ; oboInOwl:hasDbXref "FMA:85250" ; oboInOwl:hasExactSynonym "lacrimal gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011857" ; a owl:Class ; rdfs:label "acinus of lacrimal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001817 ] ) ] . obo:UBERON_0011858 obo:IAO_0000115 "An acinus that is part of a exocrine gland." ; oboInOwl:hasExactSynonym "exocrine gland acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011858" ; a owl:Class ; rdfs:label "acinus of exocrine gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002365 ] ) ] . obo:UBERON_0011859 obo:IAO_0000115 "The internal auditory meatus (also internal acoustic meatus, internal auditory canal, and internal acoustic canal) is a canal in the petrous bone of the temporal bone of the skull that carries nerves from inside the cranium towards the middle and inner ear compartments namely cranial nerve VII and cranial nerve VIII." ; oboInOwl:hasDbXref "FMA:53163", "NCIT:C95443", "SCTID:264484004", "UMLS:C0149591", "Wikipedia:Internal_auditory_meatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal acoustic canal", "internal acoustic meatus", "internal auditory canal", "internal auditory meatus", "porus acusticus internus" ; oboInOwl:id "UBERON:0011859" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Alternate def: The internal acoustic meatus (or internal auditory meatus ) is an opening on the medial surface of the petrous temporal bone. It is through this passageway that the facial nerve (cranial nerve VII) and vestibulocochlear nerve (cranial nerve VIII) pass to reach their sites of innervation. The vestibulocochlear nerve divides at the internal acoustic meatus to continue as separate vestibular and cochlear components. [MURDOCH:908]" ; rdfs:label "internal acoustic meatus" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001846 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001647 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001648 ], _:genid153686 . obo:UBERON_0011860 obo:UBPROP_0000012 "the FMA class specifically refers to ureter" ; oboInOwl:hasDbXref "FMA:63212", "MESH:D024022", "NCIT:C32339", "NIF_Subcellular:sao7547390221" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011860" ; a owl:Class ; rdfs:label "collection of collagen fibrils" ; rdfs:seeAlso obo:UBERON_0007377 ; rdfs:subClassOf obo:UBERON_0000476, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0005581 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0098643 ] . obo:UBERON_0011861 obo:IAO_0000115 "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011861" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aorta collagen fibril" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0004664 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004664 ] ) ] . obo:UBERON_0011862 obo:IAO_0000115 "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011862" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary collagen fibril" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0011863 obo:IAO_0000115 "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011863" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bone collagen fibril" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_0011864 obo:IAO_0000115 "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011864" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tendon collagen fibril" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000043 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000043 ] ) ] . obo:UBERON_0011865 obo:IAO_0000115 "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011865" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "corneal stroma collagen fibril" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001777 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011860 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001777 ] ) ] . obo:UBERON_0011871 obo:IAO_0000115 "A cranial suture that connects a nasal bone and connects a maxilla." ; oboInOwl:hasDbXref "FMA:52960" ; oboInOwl:hasExactSynonym "nasomaxillary suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "articulation of the nasal bone with maxilla" ; oboInOwl:id "UBERON:0011871" ; a owl:Class ; rdfs:label "nasomaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001681 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_0011875 obo:IAO_0000115 "A skeletal ligament that is part of a sternoclavicular joint." ; oboInOwl:hasDbXref "FMA:63980", "SCTID:182386007" ; oboInOwl:hasExactSynonym "ligamentum sternoclavicularis", "sternoclavicular joint ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011875" ; a owl:Class ; rdfs:label "ligament of sternoclavicular joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001469 ] ) ] . obo:UBERON_0011877 obo:IAO_0000115 "The lateral border that separates the dorsum from the inferior surface of the tongue on each side, the two borders meeting anteriorly at the apex.." ; oboInOwl:hasDbXref "FMA:54650", "SCTID:368572007", "SCTID:368594004" ; oboInOwl:hasExactSynonym "margo linguae", "tongue margin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011877" ; a owl:Class ; rdfs:label "margin of tongue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ; owl:equivalentClass _:genid151622 . obo:UBERON_0011878 obo:IAO_0000115 "A muscle layer that is part of a wall of esophagus." ; obo:UBPROP_0000010 "In the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle" ; oboInOwl:hasDbXref "FMA:62998" ; oboInOwl:hasExactSynonym "muscle coat of esophagus", "muscular coat of oesophagus", "muscular layer of oesophagus", "tela muscularis (oesophagus)", "tunica muscularis esophagi", "tunica muscularis oesophageae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011878" ; a owl:Class ; rdfs:label "muscle layer of esophagus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001096 ], _:genid153761 ; owl:equivalentClass _:genid151632 . obo:UBERON_0011892 obo:IAO_0000115 "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." ; oboInOwl:hasDbXref "EMAPA:37417", "SCTID:280656002" ; oboInOwl:hasExactSynonym "Haller tunica vascula", "anterior part of uveal tract", "anterior uveal tract", "anterior vascular layer of the eyeball", "anterior vascular tunic of the eye", "tunica vasculosa bulbosa", "ventral uveal tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ciliary body and iris", "vasculosa oculi" ; oboInOwl:id "UBERON:0011892" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anterior uvea" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001769 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001775 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001768 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001801 ], _:genid153772 . obo:UBERON_0011894 obo:IAO_0000115 "An organ cavity that is part of a vagina." ; oboInOwl:hasDbXref "FMA:19982" ; oboInOwl:hasExactSynonym "vaginal lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011894" ; a owl:Class ; rdfs:label "lumen of vagina" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0011899 obo:IAO_0000115 "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." ; obo:UBPROP_0000009 "The Epimysium also protects muscles from friction against other muscles and bones" ; oboInOwl:hasDbXref "FMA:9726", "NCIT:C32527", "UMLS:C0504096", "Wikipedia:Epimysium" ; oboInOwl:hasExactSynonym "fascia of muscle organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epimysia" ; oboInOwl:id "UBERON:0011899" ; a owl:Class ; rdfs:label "epimysium" ; rdfs:subClassOf obo:UBERON_0011822, [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0014892 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000043 ], _:genid153791 . obo:UBERON_0011918 obo:IAO_0000115 "The thickened peripheral margin of the vitreous membrane of the cornea." ; obo:UBPROP_0000012 "A line in FMA, a structure in MP" ; oboInOwl:hasDbXref "EMAPA:37895", "FMA:58422" ; oboInOwl:hasExactSynonym "Schwalbe line", "Schwalbe's line", "Schwalbe's ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011918" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "line of Schwalbe" ; rdfs:subClassOf obo:UBERON_0006800, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005969 ], _:genid153801 . obo:UBERON_0011919 obo:IAO_0000115 "Masses of developing blood cells attached to endothelium in the yolk sac." ; oboInOwl:hasDbXref "EHDAA2:0000177", "EMAPA:16115" ; oboInOwl:hasExactSynonym "visceral yolk sac blood island", "yolk sac blood islands" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011919" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "yolk sac blood island" ; rdfs:subClassOf _:genid153814 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003316 ] ) ] . obo:UBERON_0011921 obo:UBPROP_0000012 "in EHDAA2 gives rise to connecting stalk blood vessels and extraembryonic umbilical vessels" ; oboInOwl:hasDbXref "EHDAA2:0003242" ; oboInOwl:hasExactSynonym "blood island of umbilical vesicle", "insula sanguinea vesiculae umbilicalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011921" ; a owl:Class ; rdfs:label "connecting stalk blood islands" ; rdfs:subClassOf obo:UBERON_0007503, _:genid153820, _:genid153822 . obo:UBERON_0011922 obo:IAO_0000115 "The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes." ; oboInOwl:hasDbXref "EMAPA:37830" ; oboInOwl:hasExactSynonym "basement membrane of cochlear labyrinth", "cochlea basement membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011922" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cochlear basement membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002499 ] ) ] . obo:UBERON_0011925 obo:IAO_0000115 "Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released." ; oboInOwl:hasDbXref "FMA:5923", "MESH:D001339", "NCIT:C12624", "Wikipedia:Preganglionic_nerve_fibers" ; oboInOwl:hasExactSynonym "preganglionic nerve fiber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "preganglionic autonomic fibre" ; oboInOwl:id "UBERON:0011925" ; a owl:Class ; rdfs:label "preganglionic autonomic fiber" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0034728 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006134 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001805 ] ) ] . obo:UBERON_0011927 obo:IAO_0000115 "A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion." ; oboInOwl:hasDbXref "SCTID:323517007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sympathetic preganglionic fiber" ; oboInOwl:id "UBERON:0011927" ; a owl:Class ; rdfs:label "preganglionic sympathetic fiber" ; rdfs:subClassOf obo:UBERON_0011925, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0034729 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006134 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001806 ] ) ] . obo:UBERON_0011930 obo:IAO_0000115 "A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion." ; oboInOwl:hasDbXref "Wikipedia:Preganglionic_fibers" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "parasympathetic preganglionic fiber" ; oboInOwl:id "UBERON:0011930" ; a owl:Class ; rdfs:label "preganglionic parasympathetic fiber" ; rdfs:subClassOf obo:UBERON_0011925, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004293 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006134 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001017 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001808 ] ) ] . obo:UBERON_0011931 obo:IAO_0000115 "Hair in the nose." ; oboInOwl:hasDbXref "FMA:53670", "SCTID:368885003", "Wikipedia:Nasal_hair" ; oboInOwl:hasExactSynonym "hair of nose", "hair of vestibular part of nose", "nose hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011931" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasal hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] . obo:UBERON_0011932 obo:IAO_0000115 "An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle." ; oboInOwl:hasDbXref "EMAPA:36582", "FMA:70661", "Wikipedia:Pilosebaceous_unit" ; oboInOwl:hasExactSynonym "fabrica pilosebacea", "pilo-sebaceous apparatus", "pilo-sebaceous unit", "pilosebaceous apparatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pilosebaceous gland" ; oboInOwl:id "UBERON:0011932" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pilosebaceous unit" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001821 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002033 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002073 ], _:genid153868 . obo:UBERON_0011953 obo:IAO_0000115 "A region of the stomach that is lined with glandular epithelium." ; obo:IAO_0000116 "as currently defined, this would include the cardiac antrum; however, the intent may be to exclude the cardiac glands and in mice for this to be part of the region distal to the margo plicatus" ; oboInOwl:hasDbXref "EMAPA:17623", "MA:0001613", "NCIT:C77661", "SCTID:27633001", "UMLS:C0227197" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glandular stomach" ; oboInOwl:id "UBERON:0011953" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "stomach glandular region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009870 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006924 ] ) ] . obo:UBERON_0011955 obo:IAO_0000115 "A hepatic vein that is part of a left lobe of liver." ; oboInOwl:hasDbXref "EMAPA:37164", "FMA:14339", "MA:0003032", "SCTID:55188000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011955" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left hepatic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001115 ] ) ] . obo:UBERON_0011956 obo:IAO_0000115 "A hepatic vein that is part of a right lobe of liver." ; oboInOwl:hasDbXref "EMAPA:37377", "FMA:14338", "MA:0003034", "SCTID:18135006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011956" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right hepatic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001143 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001114 ] ) ] . obo:UBERON_0011960 obo:IAO_0000115 "An articular capsule that is part of the glenohumeral joint." ; oboInOwl:hasDbXref "FMA:34944", "SCTID:361836001", "Wikipedia:Articular_capsule_of_the_humerus" ; oboInOwl:hasExactSynonym "articular capsule of humerus", "articular capsule of shoulder joint", "capsule of shoulder joint", "fibrous capsule of glenohumeral joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "glenohumeral joint capsule" ; oboInOwl:id "UBERON:0011960" ; a owl:Class ; rdfs:label "articular capsule of glenohumeral joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001470 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001484 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001470 ] ) ] . obo:UBERON_0011961 obo:IAO_0000115 "An articular capsule that is part of the hip joint." ; oboInOwl:hasDbXref "FMA:42821", "SCTID:263382006", "Wikipedia:Capsule_of_hip_joint" ; oboInOwl:hasExactSynonym "capsula articularis coxae", "capsule of hip joint", "fibrous capsule of hip joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011961" ; a owl:Class ; rdfs:label "articular capsule of hip joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001486 ] ; owl:equivalentClass _:genid151773 . obo:UBERON_0011962 obo:IAO_0000115 "The transverse tarsal joint is formed by the articulation of the calcaneus with the cuboid, and the articulation of the talus with the navicular. The movement which takes place in this joint is more extensive than that in the other tarsal joints, and consists of a sort of rotation by means of which the foot may be slightly flexed or extended, the sole being at the same time carried medially (inverted) or laterally." ; oboInOwl:hasDbXref "FMA:35201", "NCIT:C102354", "SCTID:182220000", "Wikipedia:Transverse_tarsal_joint" ; oboInOwl:hasExactSynonym "articulatio tarsi transversa", "chopart's joint", "midtarsal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011962" ; a owl:Class ; rdfs:label "transverse tarsal joint" ; rdfs:subClassOf obo:UBERON_0011139, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] . obo:UBERON_0011963 obo:IAO_0000115 "The talocalcaneonavicular articulation is an arthrodial joint: the rounded head of the talus being received into the concavity formed by the posterior surface of the navicular, the anterior articular surface of the calcaneus, and the upper surface of the plantar calcaneonavicular ligament. There are two ligaments in this joint: the articular capsule and the dorsal talonavicular." ; oboInOwl:hasDbXref "FMA:35204", "SCTID:182211009", "Wikipedia:Talocalcaneonavicular_articulation" ; oboInOwl:hasExactSynonym "articulatio talocalcaneonavicularis", "talocalcaneonavicular articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011963" ; a owl:Class ; rdfs:label "talocalcaneonavicular joint" ; rdfs:subClassOf _:genid153928 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001450 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] . obo:UBERON_0011964 obo:IAO_0000115 "Calcaneocuboid Articulation (articulation of the calcaneus with the cuboid). The ligaments connecting the calcaneus with the cuboid are five in number, viz. , the articular capsule, the dorsal calcaneocuboid, part of the bifurcated, the long plantar, and the plantar calcaneocuboid." ; oboInOwl:hasDbXref "FMA:35207", "SCTID:361866008", "Wikipedia:Calcaneocuboid_articulation" ; oboInOwl:hasExactSynonym "articulatio calcaneocubiodea", "calcaneocuboid articulation", "calcaneocuboidal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011964" ; a owl:Class ; rdfs:label "calcaneocuboid joint" ; rdfs:subClassOf _:genid153939 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 _:genid151802 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001455 ] ) ] . obo:UBERON_0011968 obo:IAO_0000115 "A skeletal joint that connects a radius bone and connects a carpal skeleton." ; oboInOwl:hasBroadSynonym "wrist joint" ; oboInOwl:hasDbXref "EMAPA:19205", "FMA:35291", "MA:0000461", "SCTID:361839008" ; oboInOwl:hasExactSynonym "articulatio radiocarpea", "radiocarpal articulation", "radiocarpal joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011968" ; a owl:Class ; rdfs:label "radio-carpal joint" ; rdfs:subClassOf obo:UBERON_0001491 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001423 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0009880 ] ) ] . obo:UBERON_0011969 obo:IAO_0000115 "An ankle joint that passes between the proximal and distal tarsals." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011969" ; a owl:Class ; rdfs:comment "Calcaneus and astragalus are interlocked, line of flexion is distal to them[Kardong]" ; rdfs:label "mesotarsal joint" ; rdfs:subClassOf obo:UBERON_0001488, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010721 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011679 ] ) ] . obo:UBERON_0011970 obo:IAO_0000115 "A skeletal ligament that connects the fibula to the talus. Examples: anterior and posterior talofibular ligament." ; oboInOwl:hasDbXref "FMA:44080", "SCTID:244649001", "Wikipedia:Talofibular_ligament" ; oboInOwl:hasExactSynonym "ligamentum talofibulare", "talo-fibular ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011970" ; a owl:Class ; rdfs:label "talofibular ligament" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001488 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0012291 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg"^^xsd:anyURI . obo:UBERON_0011971 obo:IAO_0000115 "A skeletal ligament that connects the fibula to the calcaneus." ; obo:UBPROP_0000008 "In humans, it is a narrow, rounded cord, running from the apex of the fibular malleolus downward and slightly backward to a tubercle on the lateral surface of the calcaneus. It is covered by the tendons of the Peronæi longus and brevis." ; oboInOwl:hasDbXref "FMA:44089", "SCTID:244650001", "Wikipedia:Calcaneofibular_ligament" ; oboInOwl:hasExactSynonym "ligamentum calcaneofibulare" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011971" ; a owl:Class ; rdfs:label "calcaneofibular ligament" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001488 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001446 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001450 ] ) ] ; foaf:depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg"^^xsd:anyURI . obo:UBERON_0011972 obo:IAO_0000115 "A skeletal ligament that connects a tibia and connects a tarsal skeleton." ; oboInOwl:hasDbXref "FMA:44055", "SCTID:41159004" ; oboInOwl:hasExactSynonym "deltoid collateral ligament of ankle joint", "deltoid ligament of ankle joint", "ligamentum collaterale mediale (articulatio talocruralis)", "ligamentum collaterale mediale articulationis talocruralis", "ligamentum deltoideum", "ligamentum deltoideum (articulatio talocruralis)", "medial collateral ligament of ankle joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011972" ; a owl:Class ; rdfs:label "medial ligament of ankle joint" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001488 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0009879 ] ) ] . obo:UBERON_0011973 obo:IAO_0000115 "An epiphysis that is part of a phalanx of a pes [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:314621001" ; oboInOwl:hasExactSynonym "epiphysis of phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011973" ; a owl:Class ; rdfs:label "epiphysis of phalanx of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0011974 obo:IAO_0000115 "An epiphysis that is part of a proximal phalanx of pes." ; oboInOwl:hasDbXref "SCTID:280047006" ; oboInOwl:hasExactSynonym "epiphysis of proximal phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011974" ; a owl:Class ; rdfs:label "epiphysis of proximal phalanx of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 _:genid151871 ) ] . obo:UBERON_0011975 obo:IAO_0000115 "An epiphysis that is part of a middle phalanx of pes." ; oboInOwl:hasDbXref "SCTID:280048001" ; oboInOwl:hasExactSynonym "epiphysis of middle phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011975" ; a owl:Class ; rdfs:label "epiphysis of middle phalanx of pes" ; owl:equivalentClass _:genid151874 . obo:UBERON_0011976 obo:IAO_0000115 "An epiphysis that is part of a distal phalanx of pes." ; oboInOwl:hasDbXref "SCTID:280049009" ; oboInOwl:hasExactSynonym "epiphysis of distal phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011976" ; a owl:Class ; rdfs:label "epiphysis of distal phalanx of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 _:genid151881 ) ] . obo:UBERON_0011977 obo:IAO_0000115 "An epiphysis that is part of a proximal phalanx of manus." ; oboInOwl:hasDbXref "SCTID:280044004" ; oboInOwl:hasExactSynonym "epiphysis of proximal phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011977" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphysis of proximal phalanx of manus" ; owl:equivalentClass _:genid151884 . obo:UBERON_0011978 obo:IAO_0000115 "An epiphysis that is part of a middle phalanx of manus." ; oboInOwl:hasDbXref "SCTID:280045003" ; oboInOwl:hasExactSynonym "epiphysis of middle phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011978" ; a owl:Class ; rdfs:label "epiphysis of middle phalanx of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 _:genid151891 ) ] . obo:UBERON_0011979 obo:IAO_0000115 "An epiphysis that is part of a distal phalanx of manus." ; oboInOwl:hasDbXref "FMA:321561", "SCTID:280046002" ; oboInOwl:hasExactSynonym "epiphysis of distal phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0011979" ; a owl:Class ; rdfs:label "epiphysis of distal phalanx of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] . obo:UBERON_0011980 obo:IAO_0000115 "A joint that connects the bones of the crus to the proximal tarsal bones." ; obo:UBPROP_0000001 "an ankle joint that passes between the astragalus and calcaneum[Palaeos]." ; oboInOwl:hasDbXref "Wikipedia:Crurotarsal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "crurotarsal" ; oboInOwl:id "UBERON:0011980" ; a owl:Class ; rdfs:comment "line of flexion between calcaneus and astragalus" ; rdfs:label "crurotarsal joint" ; rdfs:subClassOf obo:UBERON_0001488 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010720 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011679 ] ) ] . obo:UBERON_0011997 obo:IAO_0000115 "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." ; obo:IAO_0000116 "EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining." ; obo:RO_0002161 obo:NCBITaxon_147099 ; obo:UBPROP_0000007 "coelomic" ; oboInOwl:hasDbXref "EHDAA2:0004731", "Wikipedia:Coelom" ; oboInOwl:hasNarrowSynonym "enterocoelom", "haemocoelom", "schizocoelom" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "coelem", "coelomic cavity" ; oboInOwl:id "UBERON:0011997" ; a owl:Class ; rdfs:label "coelom" ; rdfs:subClassOf obo:UBERON_0000481 . obo:UBERON_0012054 obo:IAO_0000115 "The cavity within a myotome." ; obo:UBPROP_0000003 "The central cavity within the mesoderm is the paired primary or embryonic coelom. Parts of the embryonic coelom often become enclosed in the mesoderm, forming a myocoel within the epimere, a nephrocoel within the mesomere, and simple coelom (body cavity) within the lateral plate mesoderm.[well established][VHOG]" ; oboInOwl:hasDbXref "EMAPA:31134", "VHOG:0001283" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012054" ; a owl:Class ; rdfs:label "myocoele" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003082 ] ) ] . obo:UBERON_0012069 oboInOwl:hasDbXref "FMA:62811" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012069" ; a owl:Class ; rdfs:label "epithelium-associated lymphoid tissue" ; rdfs:subClassOf obo:UBERON_0001744 . obo:UBERON_0012070 obo:IAO_0000115 "A tooth that is on the roof of the mouth." ; oboInOwl:hasExactSynonym "palatal teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012070" ; a owl:Class ; rdfs:label "palatal tooth" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009680 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid151920 ] . obo:UBERON_0012071 obo:IAO_0000115 "Any bone that is part of a palate." ; obo:IAO_0000232 "this is distinct (but not disjoint) from palatine bone" ; oboInOwl:hasDbXref "EMAPA:37930", "NCIT:C33248", "UMLS:C1518857" ; oboInOwl:hasExactSynonym "palatal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012071" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "palate bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007375 ] ) ] . obo:UBERON_0012072 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dermatocranium, palatal series", "palatal series" ; oboInOwl:id "UBERON:0012072" ; a owl:Class ; rdfs:label "palatal part of dermatocranium" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007375 ] . obo:UBERON_0012073 obo:IAO_0000115 "A tooth that is attached to a palatine bone." ; obo:UBPROP_0000001 "Teeth present in some fishes on the palatine bones, bones that lie inside the upper jaw bones (sometimes maxillaries, sometimes premaxillaries) usually behind the vomerine tooth patch." ; oboInOwl:hasExactSynonym "palatine teeth", "palatine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012073" ; a owl:Class ; rdfs:label "tooth of palatine bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001682 ] ) ] . obo:UBERON_0012074 obo:IAO_0000115 "A subdivision of skeletal system that subdivision_of a hard palate." ; oboInOwl:hasDbXref "EMAPA:37444", "FMA:59857" ; oboInOwl:hasExactSynonym "bony palate", "hard palate skeleton", "palatum osseum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012074" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bony part of hard palate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012072 ], _:genid154083 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000075 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0003216 ] ) ] . obo:UBERON_0012075 obo:IAO_0000115 "Bone that forms as a replacement of another structural tissue." ; obo:UBPROP_0000001 "Bone that forms as a replacement of another structural tissue.[TAO]" ; obo:UBPROP_0000012 "This class was introduced to be consistent with the ZFA hierarchy. The corresponding TAO term was obsoleted, and never introduced into VSAO. Note that VSAO does have replacement element." ; oboInOwl:hasDbXref "AAO:0010768", "TAO:0001637", "ZFA:0001628" ; oboInOwl:hasExactSynonym "replacement bones" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012075" ; a owl:Class ; rdfs:label "replacement bone" ; rdfs:subClassOf obo:UBERON_0001474, obo:UBERON_0010522 . obo:UBERON_0012076 obo:IAO_0000115 "A skeletal joint that connects a tibia and connects a talus." ; obo:UBPROP_0000012 "see also FMA:44063 ! tibiotalar part of medial ligament of ankle joint" ; oboInOwl:hasBroadSynonym "ankle joint" ; oboInOwl:hasDbXref "SCTID:361864006" ; oboInOwl:hasNarrowSynonym "talotibial joint", "tibioastragalar joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012076" ; a owl:Class ; rdfs:label "tibiotalar joint" ; rdfs:subClassOf obo:UBERON_0001488 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000979 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] . obo:UBERON_0012080 obo:IAO_0000115 "A cartilaginous condensation that has the potential to develop into a patella." ; obo:IAO_0000116 "Note some sources have this as intramembranous" ; oboInOwl:hasDbXref "EMAPA:19140" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012080" ; a owl:Class ; rdfs:label "patella cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0012081 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001485 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005863 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002446 ] ) ] . obo:UBERON_0012081 obo:IAO_0000115 "A pre-cartilage condensation that has the potential to develop into a patella." ; oboInOwl:hasDbXref "EMAPA:18510" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012081" ; a owl:Class ; rdfs:label "patella pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ], _:genid154121 ; owl:equivalentClass _:genid151981 . obo:UBERON_0012082 obo:IAO_0000115 "An anatomical cavity that is part of a bronchus." ; oboInOwl:hasDbXref "FMA:62646", "SCTID:199401001" ; oboInOwl:hasExactSynonym "bronchial lumen", "lumen of bronchus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012082" ; a owl:Class ; rdfs:label "bronchial lumen" ; rdfs:subClassOf _:genid154129 ; owl:equivalentClass _:genid154124 . obo:UBERON_0012102 obo:IAO_0000115 "A salivary gland that is part of a cheek." ; oboInOwl:hasDbXref "FMA:59793", "NCIT:C32237" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012102" ; a owl:Class ; rdfs:label "buccal salivary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ] ) ] . obo:UBERON_0012111 obo:IAO_0000115 "A space or gap between two teeth." ; obo:UBPROP_0000008 "Many species of mammals have diastemata as a normal feature, most commonly between the incisors and molars" ; oboInOwl:hasAlternativeId "UBERON:0013134" ; oboInOwl:hasDbXref "FMA:77271", "MESH:D003970", "SCTID:410003009", "Wikipedia:Diastema_(dentistry)" ; oboInOwl:hasExactSynonym "interdental space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "diastemata" ; oboInOwl:id "UBERON:0012111" ; a owl:Class ; rdfs:comment "Some animals, like horses, that have diastema between incisors and premolars because canines were evolutionarily loss, sometimes have a vestigial canine in the diastema, but the diastema is still considered between the incisor and premolar." ; rdfs:label "diastema" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003672 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001091 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0001091 ; owl:onProperty obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] . obo:UBERON_0012126 obo:IAO_0000115 "One of two elements that constitute the basal row of tarsals. The fibulare constitutes the preaxial element[AAO]." ; obo:UBPROP_0000001 "One of two element that constitute the basal row of tarsals. The fibulare constitutes the preaxial element. In salamanders this element is aproximatelly rounded, whereas in anurans it is an elongate, cylindrical bone with the proximal and distal heads fused to the heads of the tibiale.[AAO]" ; obo:UBPROP_0000008 "In salamanders this element is aproximatelly rounded, whereas in anurans it is an elongate, cylindrical bone with the proximal and distal heads fused to the heads of the tibiale" ; oboInOwl:hasDbXref "AAO:0000913" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "astragalus" ; oboInOwl:id "UBERON:0012126" ; a owl:Class ; rdfs:label "fibulare" ; rdfs:subClassOf obo:UBERON_0002513, obo:UBERON_0011679, [ a owl:Restriction ; owl:onProperty obo:BSPO_0001113 ; owl:someValuesFrom obo:UBERON_0009879 ], _:genid154146 . obo:UBERON_0012128 obo:IAO_0000115 "Outermost point on an external nose or snout." ; oboInOwl:hasDbXref "EMAPA:37915", "FMA:59518", "SCTID:361926005" ; oboInOwl:hasExactSynonym "apex nasi", "apex of nose", "nasal tip", "tip of nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pirula", "snout tip", "tip of snout" ; oboInOwl:id "UBERON:0012128" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nose tip" ; rdfs:subClassOf obo:UBERON_0006983, _:genid154153 . obo:UBERON_0012131 obo:IAO_0000115 "Endochondral bone located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE]." ; obo:IAO_0000232 "This term corresponds both to the navicular bone in the pes and the similar central carpals in the manus" ; obo:UBPROP_0000012 "the FMA term is under 'general anatomical term'." ; oboInOwl:hasDbXref "EMAPA:36170", "FMA:77232" ; oboInOwl:hasExactSynonym "central mesopodium bone", "os centrale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "centralia" ; oboInOwl:id "UBERON:0012131" ; a owl:Class ; rdfs:label "centrale" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015077 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015067 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0012139 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012139" ; a owl:Class ; rdfs:label "segment of autopod" ; rdfs:subClassOf obo:UBERON_0002529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] . obo:UBERON_0012140 obo:IAO_0000115 "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "acropodium (Wagner)" ; oboInOwl:id "UBERON:0012140" ; a owl:Class ; rdfs:label "digitopodium region" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006716 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012139 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0012150 ] ) ] . obo:UBERON_0012141 obo:IAO_0000115 "A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012141" ; a owl:Class ; rdfs:label "manual digitopodium region" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0012151 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152040 ] . obo:UBERON_0012142 obo:IAO_0000115 "A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012142" ; a owl:Class ; rdfs:label "pedal digitopodium region" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0012152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012140 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0012150 obo:IAO_0000115 "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digitopodium", "skeleton of digits" ; oboInOwl:id "UBERON:0012150" ; a owl:Class ; rdfs:label "skeleton of digitopodium" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006717 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012140 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0012140 ] ) ] . obo:UBERON_0012151 obo:IAO_0000115 "A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digitopodium" ; oboInOwl:id "UBERON:0012151" ; a owl:Class ; rdfs:label "skeleton of manual digitopodium" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ], _:genid154205 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0012152 obo:IAO_0000115 "A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton." ; obo:UBPROP_0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digitopodium" ; oboInOwl:id "UBERON:0012152" ; a owl:Class ; rdfs:label "skeleton of pedal digitopodium" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod"^^xsd:anyURI ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001445 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012142 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152068 ] . obo:UBERON_0012167 obo:IAO_0000115 "The Buccal fat pad is one of several encapsulated fat masses in the cheek. It is a deep fat pad located on either side of the face between the buccinator muscle and several more superficial muscles. It should not be confused with the malar fat pad, which is directly below the skin of the cheek. It should also not be confused with jowl fat pads. It is implicated in the formation of hollow cheeks and the nasolabial fold, but not in the formation of jowls." ; oboInOwl:hasDbXref "FMA:59799", "SCTID:25930004", "Wikipedia:Buccal_fat_pad" ; oboInOwl:hasExactSynonym "Bichat's fat pad", "cheek fat pad" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012167" ; a owl:Class ; rdfs:label "buccal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152075 ] . obo:UBERON_0012168 obo:IAO_0000115 "Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." ; oboInOwl:hasDbXref "BTO:0004053", "CALOHA:TS-1079", "EFO:0001942", "MESH:D005312", "Wikipedia:Cord_blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cord blood", "fetal blood", "umbilical cord blood" ; oboInOwl:id "UBERON:0012168" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:comment "Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders.[WP]" ; rdfs:label "umbilical cord blood" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001310 ] ) ] . obo:UBERON_0012172 obo:IAO_0000115 "A primordium that has the potential to develop into a stomach." ; oboInOwl:hasDbXref "EFO:0002580", "NCIT:C34305", "UMLS:C1514976" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "stomach endoderm" ; oboInOwl:id "UBERON:0012172" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "stomach primordium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003258 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0012175 oboInOwl:hasDbXref "EHDAA2:0000494", "EMAPA:16794", "SCTID:361514006", "VHOG:0000715" ; oboInOwl:hasExactSynonym "acousticofacial ganglion", "facio-acoustic ganglion", "facio-acoustic ganglion complex VII-VIII" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facio-acoustic VII-VIII ganglion complex", "facio-acoustic ganglion complex" ; oboInOwl:id "UBERON:0012175" ; a owl:Class ; rdfs:label "acoustico-facial VII-VIII ganglion complex" ; rdfs:subClassOf obo:UBERON_0001714, _:genid154239, _:genid154241 . obo:UBERON_0012177 obo:IAO_0000115 "An apocrine gland that is part of a skin of body." ; oboInOwl:hasDbXref "MA:0000147" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012177" ; a owl:Class ; rdfs:comment "Note that 'skin apocrine gland' does not cover 'apocrine sweat gland': in the former, \"apocrine\" refers to the type of secretion mechanism, while in the latter it refers to a structural feature." ; rdfs:label "skin apocrine gland" ; rdfs:subClassOf obo:UBERON_0002419 ; owl:equivalentClass _:genid152103 . obo:UBERON_0012180 obo:IAO_0000115 "A zone of skin that is part of a craniocervical region." ; oboInOwl:hasDbXref "EMAPA:37276", "MA:0000574", "NCIT:C12294", "UMLS:C1522650" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012180" ; a owl:Class ; rdfs:label "head or neck skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0012193 obo:IAO_0000115 "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins." ; oboInOwl:hasDbXref "EMAPA:37180", "MA:0002194", "NCIT:C53062", "UMLS:C1709532" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012193" ; a owl:Class ; rdfs:label "phrenic vein" ; owl:equivalentClass _:genid152116 . obo:UBERON_0012197 obo:IAO_0000115 "The intercostal veins are a group of veins which drain the area between the ribs." ; oboInOwl:hasDbXref "EMAPA:18762", "MA:0003166", "SCTID:281057004", "Wikipedia:Intercostal_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012197" ; a owl:Class ; rdfs:label "intercostal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0012198 ] ) ] . obo:UBERON_0012198 obo:IAO_0000115 "A space in the rib cage between two successive ribs." ; oboInOwl:hasDbXref "FMA:12243", "SCTID:243937005", "Wikipedia:Intercostal_space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012198" ; a owl:Class ; rdfs:label "intercostal space" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003252 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002228 ] . obo:UBERON_0012236 obo:IAO_0000115 "The intercostal lymph nodes (intercostal glands ) occupy the posterior parts of the intercostal spaces, in relation to the intercostal vessels. They receive the deep lymphatics from the postero-lateral aspect of the chest; some of these vessels are interrupted by small lateral intercostal glands." ; oboInOwl:hasDbXref "FMA:5932", "NCIT:C77652", "SCTID:204088001", "UMLS:C0229761", "Wikipedia:Intercostal_lymph_nodes" ; oboInOwl:hasExactSynonym "intercostal node", "nodi lymphoidei intercostales", "nodus intercostale" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012236" ; a owl:Class ; rdfs:label "intercostal lymph node" ; rdfs:subClassOf obo:UBERON_0007644 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0012198 ] ) ] . obo:UBERON_0012239 obo:IAO_0000115 "Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]." ; oboInOwl:hasDbXref "EMAPA:28679" ; oboInOwl:hasExactSynonym "bladder vasculature", "blood vessels of bladder", "set of urinary bladder blood vessels" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "blood vessel of bladder" ; oboInOwl:id "UBERON:0012239" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "urinary bladder vasculature" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001255 ] ; owl:equivalentClass _:genid154284 . obo:UBERON_0012240 obo:IAO_0000115 "External opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia[MP]." ; oboInOwl:hasDbXref "EMAPA:37977", "FMA:19650", "SCTID:181424008", "Wikipedia:Urinary_meatus" ; oboInOwl:hasExactSynonym "external meatus of urethra", "external urethral orifice", "external urethral ostium", "external urinary meatus", "meatus urinarius", "orificium urethrae externum", "orificium urethræ externum", "urethral meatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "urinary meatus" ; oboInOwl:id "UBERON:0012240" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "urethral meatus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010390 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013514 ] ) ] . obo:UBERON_0012241 obo:IAO_0000115 "A urethral meatus that is part of a male urethra[Automatically generated definition]." ; obo:UBPROP_0000001 "The external urethral orifice is the external opening or meatus of the urethra, normally placed at the tip of glans penis; it presents as a vertical slit, possibly bounded on either side by two small labia-like projections, In some cases the slit may be more rounded. This occurs naturally in some males and may also be a side effect of excess skin removal during circumcision. Congenital misplacement of the urethral orifice is called hypospadias when it is located in the underside (ventral aspect) of the penis, and epispadias when located in the dorsum (upper aspect). Improper shaping of the meatus can result in meatal stenosis." ; oboInOwl:hasDbXref "EMAPA:36434", "FMA:85265", "MA:0002642", "SCTID:279478000", "Wikipedia:External_urethral_orifice_(male)" ; oboInOwl:hasExactSynonym "external orifice of male urethra", "external urethral orifice (male)", "male urethra ostium", "ostium urethrae externum (urethra masculina)", "urethral meatus of penile urethra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal urethral opening of male", "urethral opening of penile urethra" ; oboInOwl:id "UBERON:0012241" ; a owl:Class ; rdfs:label "male urethral meatus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001299 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012240 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] . obo:UBERON_0012242 obo:IAO_0000115 "The usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone." ; oboInOwl:hasDbXref "FMA:85263", "SCTID:362228001", "Wikipedia:Internal_urethral_orifice" ; oboInOwl:hasExactSynonym "internal meatus of urethra", "internal urethral orifice of urinary bladder", "internal urethral ostium", "orificium urethrae internum", "ostium orificium internum", "ostium urethrae internum", "vesicourethral orifice" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal urethral ostium", "internal urinary meatus" ; oboInOwl:id "UBERON:0012242" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "internal urethral orifice" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0009958 ] _:genid152188 ) ] . obo:UBERON_0012247 obo:IAO_0000115 "Mucus-secreting glands in the mucosa of the uterine cervix." ; obo:UBPROP_0000202 obo:FMA_71646 ; oboInOwl:hasDbXref "NCIT:C32296", "SCTID:280836000", "UMLS:C2724437" ; oboInOwl:hasExactSynonym "glandulae cervicales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012247" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical gland" ; rdfs:subClassOf obo:UBERON_0000414, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012248 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152201 ] . obo:UBERON_0012248 obo:IAO_0000115 "Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing." ; oboInOwl:hasDbXref "BTO:0000411" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012248" ; a owl:Class ; rdfs:label "cervical mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0012249 obo:IAO_0000115 "The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium." ; obo:UBPROP_0000012 "distinction between two FMA classes not clear - we merge them here" ; oboInOwl:hasAlternativeId "UBERON:0010182" ; oboInOwl:hasDbXref "BTO:0001850", "CALOHA:TS-1098", "FMA:77056", "FMA:86484", "NCIT:C12310", "SCTID:264459002", "UMLS:C0227829", "Wikipedia:Vaginal_portion_of_cervix" ; oboInOwl:hasExactSynonym "ectocervix", "portio vaginalis", "portio vaginalis cervicis", "uterine ectocervix", "vaginal part of cervix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "exocervix" ; oboInOwl:id "UBERON:0012249" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "ectocervix" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010304 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000100 ; owl:someValuesFrom obo:UBERON_0000996 ], _:genid154361 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152214 ] . obo:UBERON_0012250 obo:IAO_0000115 "A glandular epithelium that is part of a uterine cervix." ; obo:UBPROP_0000010 "The 'glandular' or columnar epithelium of the cervix is located cephalad to the squamocolumnar junction. It covers a variable amount of the ectocervix and lines the endocervical canal. It is comprised of a single layer of mucin-secreting cells. The epithelium is thrown into longitudinal folds and invaginations that make up the so-called endocervical glands (they are not true glands). These infolding crypts and channels make the cytologic and colposcopic detection of neoplasia less reliable and more problematic. The complex architecture of the endocervical glands gives the columnar epithelium a papillary appearance through the colposcope and a grainy appearance upon gross visual inspection. The single cell layer allows the coloration of the underlying vasculature to be seen more easily. Therefore, the columnar epithelium appears more red in comparison with the more opaque squamous epithelium." ; oboInOwl:hasDbXref "NCIT:C54414", "UMLS:C1707350" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervix columnar epithelium" ; oboInOwl:id "UBERON:0012250" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervix glandular epithelium" ; owl:equivalentClass _:genid152229 . obo:UBERON_0012251 obo:IAO_0000115 "An epithelium that is part of a ectocervix." ; oboInOwl:hasDbXref "SCTID:361376000" ; oboInOwl:hasExactSynonym "exocervical epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012251" ; a owl:Class ; rdfs:label "ectocervical epithelium" ; owl:equivalentClass _:genid152236 . obo:UBERON_0012252 obo:IAO_0000115 "The glandular epithelium that lines the endocervix." ; oboInOwl:hasDbXref "NCIT:C96180", "SCTID:362256006" ; oboInOwl:hasExactSynonym "endocervical glandular epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012252" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endocervical epithelium" ; rdfs:subClassOf obo:UBERON_0006799 ; owl:equivalentClass _:genid152241 . obo:UBERON_0012253 obo:IAO_0000115 "Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet." ; oboInOwl:hasBroadSynonym "squamocolumnar junction" ; oboInOwl:hasDbXref "NCIT:C97148", "SCTID:280451001" ; oboInOwl:hasExactSynonym "squamo-columnar junction of uterine cervix", "squamocolumnar junction of uterine cervix" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012253" ; a owl:Class ; rdfs:comment "Site of 90% of lower genital tract neoplasia. This junction is presumed, but not proven, to be the embryologic junction of the Müllerian and urogenital sinus epithelia." ; rdfs:label "cervical squamo-columnar junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152247 ] . obo:UBERON_0012254 obo:IAO_0000115 "An artery that originates from the abdominal aorta." ; oboInOwl:hasDbXref "SCTID:281470000" ; oboInOwl:hasExactSynonym "abdominal artery", "artery of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012254" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "abdominal aorta artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 _:genid152257 ) ] . obo:UBERON_0012274 obo:IAO_0000115 "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]." ; oboInOwl:hasDbXref "Wikipedia:Columnar_epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012274" ; a owl:Class ; rdfs:label "columnar epithelium" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000075 ] . obo:UBERON_0012275 obo:IAO_0000115 "Epithelium that derives from the mesoderm. [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:86452" ; oboInOwl:hasExactSynonym "mesoderm-derived epithelium", "mesoepithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012275" ; a owl:Class ; rdfs:label "meso-epithelium" ; owl:equivalentClass _:genid152262 . obo:UBERON_0012276 oboInOwl:hasDbXref "EMAPA:35308", "FMA:86488", "MA:0002732" ; oboInOwl:hasExactSynonym "glandular part of endometrium", "uterine glands", "uterine glands set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012276" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endometrium glandular epithelium" ; rdfs:subClassOf obo:UBERON_0007592 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152268 ] . obo:UBERON_0012278 obo:IAO_0000115 "The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands." ; oboInOwl:hasBroadSynonym "nasal gland" ; oboInOwl:hasDbXref "EMAPA:37871", "FMA:321518", "NCIT:C22725", "SCTID:368881007", "UMLS:C1522269", "Wikipedia:Nasal_glands" ; oboInOwl:hasExactSynonym "glandula nasalis", "glandulae nasales" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012278" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gland of nasal mucosa" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000159 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001826 ] ) ] . obo:UBERON_0012282 obo:IAO_0000115 "Encapsulated adipose tissue associated with the mammary gland." ; oboInOwl:hasDbXref "EMAPA:37901" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012282" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "mammary fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0012283 obo:IAO_0000115 "Encapsulated adipose tissue associated with the femur." ; oboInOwl:hasExactSynonym "femoral fat depot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012283" ; a owl:Class ; rdfs:label "femoral fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ] . obo:UBERON_0012288 obo:IAO_0000115 "A tarsal bone that is formed from the fusion of the central and 4th tarsal bones." ; oboInOwl:hasExactSynonym "os centroquartale", "os naviculocuboideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012288" ; a owl:Class ; rdfs:label "centroquartal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152297 ] . obo:UBERON_0012289 obo:IAO_0000115 "A tarsal bone that is formed from the fusion of the 2nd and 3rd tarsal bones." ; oboInOwl:hasExactSynonym "fused tarsals 2 and 3", "os cuneiforme intermediolaterale", "os tarsale II et III" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tarsals 2+3" ; oboInOwl:id "UBERON:0012289" ; a owl:Class ; rdfs:label "fused tarsal bones 2 and 3" ; rdfs:subClassOf obo:UBERON_0010721 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001453 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001454 ] ) ] . obo:UBERON_0012290 obo:IAO_0000115 "A carpal bone that is formed from the fusion of the 2nd and 3rd distal carpal bones." ; oboInOwl:hasExactSynonym "fused carpals 2 and 3" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpals 2+3" ; oboInOwl:id "UBERON:0012290" ; a owl:Class ; rdfs:label "fused carpal bones 2 and 3" ; rdfs:subClassOf obo:UBERON_0001481 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001435 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001431 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001432 ] ) ] . obo:UBERON_0012291 obo:IAO_0000115 "Malleolus is the name for the bony prominence on each side of the ankle." ; obo:UBPROP_0000008 "In bovids, the distal end of the fibula is present only as the lateral malleolus, a separate bone that articulates with the lateral side of the distal tibia." ; oboInOwl:hasBroadSynonym "lateral malleolus" ; oboInOwl:hasDbXref "EMAPA:37893", "FMA:35502", "SCTID:361795009", "Wikipedia:Malleolus" ; oboInOwl:hasNarrowSynonym "malleolar bone", "malleolar bone of ankle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal extremity of fibula", "external malleolus of fibula", "fibular malleolus" ; oboInOwl:id "UBERON:0012291" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lateral malleolus of fibula" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004410 ] . obo:UBERON_0012292 obo:IAO_0000115 "One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly." ; oboInOwl:hasBroadSynonym "cloacal fold" ; oboInOwl:hasDbXref "EHDAA2:0004009" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012292" ; a owl:Class ; rdfs:comment "We presume this is distinct from AAO:0001003, an external integumentary structure - check with amphibian anatomy ontology developers. AO notes: the text def states mesenchymal swelling, EHDAA2 splits into mesenchymal and epithelial parts" ; rdfs:label "embryonic cloacal fold" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006217 ], _:genid154476 . obo:UBERON_0012299 obo:IAO_0000115 "A mucosa that is part of a urethra." ; oboInOwl:hasDbXref "EMAPA:37912", "FMA:76904", "SCTID:362229009" ; oboInOwl:hasExactSynonym "mucous membrane of urethra", "tunica mucosa urethrae", "urethral mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012299" ; a owl:Class ; rdfs:label "mucosa of urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0012313 oboInOwl:hasDbXref "EHDAA2:0000039", "EMAPA:16389" ; oboInOwl:hasExactSynonym "ectoderm of maxillary component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012313" ; a owl:Class ; rdfs:label "1st arch maxillary ectoderm" ; rdfs:subClassOf obo:UBERON_0000490, _:genid154491, _:genid154493, _:genid154495 . obo:UBERON_0012314 obo:IAO_0000115 "One of five swellings formed during the development of the face." ; oboInOwl:hasDbXref "FMA:293103", "SCTID:89066004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "embryonic facial process", "facial primordium", "primordium of face" ; oboInOwl:id "UBERON:0012314" ; a owl:Class ; rdfs:label "embryonic facial prominence" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] . obo:UBERON_0012317 obo:IAO_0000115 "The median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice." ; oboInOwl:hasBroadSynonym "introitus" ; oboInOwl:hasDbXref "EMAPA:37983", "FMA:19984", "Wikipedia:Vaginal_orifice" ; oboInOwl:hasExactSynonym "opening of vagina", "orifice of vagina", "ostium vaginae", "vagina opening", "vaginal orifice" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "introitus", "introitus of vagina", "vaginal introitus" ; oboInOwl:id "UBERON:0012317" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vagina orifice" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 _:genid152354 ) ] . obo:UBERON_0012318 obo:IAO_0000115 "The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP]." ; oboInOwl:hasDbXref "FMA:49986", "SCTID:312160004", "Wikipedia:Anterior_ethmoidal_artery" ; oboInOwl:hasExactSynonym "a. ethmoidalis anterior", "arteria ethmoidalis anterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior ethmoid artery", "anterior meningeal arteries", "anterior meningeal artery" ; oboInOwl:id "UBERON:0012318" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "anterior ethmoidal artery" ; rdfs:subClassOf obo:UBERON_0005193 ; owl:disjointWith obo:UBERON_0012319 . obo:UBERON_0012319 obo:IAO_0000115 "The posterior ethmoidal artery is an artery of the head. It is smaller than the anterior ethmoidal artery, branches off from the ophthalmic artery when it reaches the medial wall of the orbit." ; oboInOwl:hasDbXref "FMA:49989", "SCTID:312161000", "Wikipedia:Posterior_ethmoidal_artery" ; oboInOwl:hasExactSynonym "a. ethmoidalis posterior", "arteria ethmoidalis posterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior ethmoidal vessel" ; oboInOwl:id "UBERON:0012319" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "posterior ethmoidal artery" ; rdfs:subClassOf obo:UBERON_0005193 . obo:UBERON_0012320 obo:IAO_0000115 "An artery of the neck." ; oboInOwl:hasDbXref "EMAPA:37075", "NCIT:C52850", "UMLS:C1707349" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012320" ; a owl:Class ; rdfs:label "cervical artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0012321 obo:IAO_0000115 "The deep cervical artery (Profunda cervicalis) is an artery of the neck." ; oboInOwl:hasDbXref "FMA:10659", "SCTID:244223002", "Wikipedia:Deep_cervical_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "profunda cervicalis" ; oboInOwl:id "UBERON:0012321" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "deep cervical artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ], _:genid154538 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012320 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] ) ] . obo:UBERON_0012324 obo:IAO_0000115 "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." ; obo:UBPROP_0000012 "Unclear if MA class belongs here or in parent" ; oboInOwl:hasDbXref "FMA:10664", "MA:0001936", "SCTID:244224008", "Wikipedia:Transverse_cervical_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervical artery", "cervical transverse artery", "descending branch of the transverse cervical", "transversalis artery colli", "transversalis colli artery", "transverse cervical", "transverse cervical vessels" ; oboInOwl:id "UBERON:0012324" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "transverse cervical artery" ; rdfs:subClassOf obo:UBERON_0012320 . obo:UBERON_0012329 obo:IAO_0000115 "Keratinized stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesize and accumulate keratin." ; oboInOwl:hasDbXref "FMA:45568", "Wikipedia:Stratified_squamous_epithelium#Keratinized" ; oboInOwl:hasExactSynonym "epithelium stratificatum squamosum cornificatum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012329" ; a owl:Class ; rdfs:label "keratinized stratified squamous epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0045095 ] ) ] . obo:UBERON_0012330 obo:IAO_0000115 "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." ; oboInOwl:hasDbXref "FMA:79771", "MA:0003030", "NCIT:C77659", "UMLS:C2698431" ; oboInOwl:hasExactSynonym "NALT", "naso-pharyngeal lymphoid tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012330" ; a owl:Class ; rdfs:label "nasal-associated lymphoid tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005022 ] ; owl:equivalentClass _:genid152407 . obo:UBERON_0012332 obo:IAO_0000115 "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis." ; oboInOwl:hasDbXref "FMA:16516", "MESH:D001956", "NCIT:C12318", "SCTID:362723009", "UMLS:C0006205", "Wikipedia:Broad_ligament_of_the_uterus" ; oboInOwl:hasExactSynonym "broad uterine ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "broad ligament", "ligamentum latum uteri" ; oboInOwl:id "UBERON:0012332" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "broad ligament of uterus" ; rdfs:subClassOf obo:UBERON_0000211, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000459 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002355 ] . obo:UBERON_0012344 obo:IAO_0000115 "Any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen." ; oboInOwl:hasDbXref "BTO:0002325", "MA:0003042", "Wikipedia:Holocrine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012344" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "holocrine gland" ; rdfs:subClassOf obo:UBERON_0002365 . obo:UBERON_0012351 obo:IAO_0000115 "An anatomical space that is enclosed by a urachus." ; oboInOwl:hasExactSynonym "urachus lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012351" ; a owl:Class ; rdfs:label "urachal lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002068 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002068 ] ) ] . obo:UBERON_0012354 obo:IAO_0000115 "The segment of the autopod that is distal to the metapodial region and consists of the digits." ; obo:IAO_0000232 "class refers to an entire limb segment, not just the bones" ; oboInOwl:hasExactSynonym "acropodial limb segment", "acropodial region", "acropodial segment of autopod", "set of digits" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012354" ; a owl:Class ; rdfs:label "acropodium region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012140 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000097 ; owl:someValuesFrom obo:UBERON_0009877 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012139 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010543 ] ) ] . obo:UBERON_0012355 obo:IAO_0000115 "The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers)." ; obo:IAO_0000232 "class refers to an entire limb segment, not just the bones" ; oboInOwl:hasDbXref "FMA:75592" ; oboInOwl:hasExactSynonym "acropodial hindlimb segment", "acropodial region of manus", "acropodial segment of manus", "all fingers", "anterior acropodium region", "anterior acropodium segment of limb", "digiti manus", "digits of hand", "fingers including thumb", "fingers set", "manual acropodium region", "manual acropodium segment of limb", "set of digits of hand", "set of fingers" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior acropodium", "manual acropodium" ; oboInOwl:id "UBERON:0012355" ; a owl:Class ; rdfs:label "manual acropodium region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010688 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012354 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0012356 obo:IAO_0000115 "The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes)." ; obo:IAO_0000232 "class refers to an entire limb segment, not just the bones" ; oboInOwl:hasDbXref "FMA:70664", "SCTID:362835004" ; oboInOwl:hasExactSynonym "acropodial forelimb segment", "acropodial region of pes", "acropodial segment of pes", "all toes", "digits of foot", "pedal acropodium region", "set of toes", "toes set" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "toes" ; oboInOwl:id "UBERON:0012356" ; a owl:Class ; rdfs:label "pedal acropodium region" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012142 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0010696 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012354 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0012357 obo:IAO_0000115 "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." ; obo:UBPROP_0000006 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit bone" ; oboInOwl:id "UBERON:0012357" ; a owl:Class ; rdfs:label "digitopodium bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152465 ] . obo:UBERON_0012358 obo:IAO_0000115 "A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton." ; obo:UBPROP_0000006 ; oboInOwl:hasDbXref "SCTID:265809008" ; oboInOwl:hasExactSynonym "bone of forelimb digitopodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012358" ; a owl:Class ; rdfs:label "manual digitopodium bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012151 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012357 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0012359 obo:IAO_0000115 "A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton." ; obo:UBPROP_0000006 ; oboInOwl:hasExactSynonym "bone of hindlimb digitopodium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012359" ; a owl:Class ; rdfs:label "pedal digitopodium bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152478 ] . obo:UBERON_0012360 obo:IAO_0000115 "A bone element that is part of a jaw region." ; obo:IAO_0000116 "Do not manually classify under here - bones are automatically classified" ; oboInOwl:hasDbXref "EMAPA:35453", "MA:0003130", "SCTID:369003004" ; oboInOwl:hasExactSynonym "jaw bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012360" ; a owl:Class ; rdfs:label "bone of jaw" ; rdfs:subClassOf obo:UBERON_0003462, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001474 _:genid152485 ) ] . obo:UBERON_0012361 oboInOwl:hasDbXref "EHDAA2:0004588" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012361" ; a owl:Class ; rdfs:label "internal anal region" ; rdfs:subClassOf obo:UBERON_0000481, _:genid154639 . obo:UBERON_0012367 obo:IAO_0000115 "A muscle layer that is part of an intestine." ; oboInOwl:hasDbXref "FMA:15697" ; oboInOwl:hasExactSynonym "intestinal muscularis propria", "muscularis externa of intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "smooth muscle of intestine" ; oboInOwl:id "UBERON:0012367" ; a owl:Class ; rdfs:label "muscle layer of intestine" ; rdfs:subClassOf _:genid154645 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0012373 obo:IAO_0000115 "A nerve plexus that is part of a sympathetic nervous system." ; oboInOwl:hasDbXref "EMAPA:37617", "MA:0001160" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012373" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sympathetic nerve plexus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001810 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000013 ] ) ] . obo:UBERON_0012375 obo:IAO_0000115 "A layer of tissue between the muscularis and serosa." ; oboInOwl:hasDbXref "FMA:45636", "NCIT:C94494", "SCTID:2255006", "UMLS:C0225334", "Wikipedia:Subserosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012375" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "Contains nerves, blood vessels, lymphatics and lymph nodes" ; rdfs:label "subserosa" ; owl:equivalentClass _:genid152504 . obo:UBERON_0012377 obo:IAO_0000115 "A muscular coat that is part of a jejunum." ; oboInOwl:hasDbXref "FMA:14951" ; oboInOwl:hasExactSynonym "muscularis externa of jejunum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "jejunal smooth muscle", "muscularis propria of jejunum", "smooth muscle of jejunum" ; oboInOwl:id "UBERON:0012377" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle layer of jejunum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0012378 obo:IAO_0000115 "A muscular coat that is part of a urinary bladder." ; oboInOwl:hasDbXref "FMA:15930", "NCIT:C32206", "UMLS:C1288327" ; oboInOwl:hasExactSynonym "bladder muscular coat", "muscle layer of urinary bladder", "muscular coat of bladder", "muscular coat of urinary bladder", "muscular layer of bladder", "muscular layer of urinary bladder", "tunica musculari vesicae", "tunica muscularis (vesica urinaria)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012378" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle layer of urinary bladder" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004228 ], _:genid154677 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) ] . obo:UBERON_0012416 oboInOwl:hasDbXref "EMAPA:37567", "MA:0001802" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012416" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory system arterial smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003643 ] ) ] . obo:UBERON_0012418 obo:IAO_0000115 "A smooth muscle tissue that is part of a respiratory system venous blood vessel." ; oboInOwl:hasDbXref "EMAPA:37586", "MA:0001812" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012418" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "respiratory system venous smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003476 ] ) ] . obo:UBERON_0012423 obo:IAO_0000115 "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." ; obo:UBPROP_0000009 "a wide variety of physiological and cellular functions including absorption, secretion, cellular adhesion, and mechanotransduction", "increases the surface area of a cell lining whilst minimizing increase in volume" ; obo:UBPROP_0000012 "FMA class represents an individual microvillus." ; oboInOwl:hasDbXref "FMA:67296", "MESH:D008871", "NCIT:C33112", "UMLS:C0026049", "Wikipedia:Microvillus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "microvilli", "microvillus" ; oboInOwl:id "UBERON:0012423" ; a owl:Class ; rdfs:label "layer of microvilli" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0005902 ] . obo:UBERON_0012425 obo:IAO_0000115 "A microvillus layer that is striated and found in the intestine." ; obo:UBPROP_0000012 "FMA class represents an individual microvillus" ; oboInOwl:hasDbXref "FMA:70978", "NCIT:C33634" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "striated border" ; oboInOwl:id "UBERON:0012425" ; a owl:Class ; rdfs:label "striated border microvillus layer" ; rdfs:subClassOf obo:UBERON_0012423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] . obo:UBERON_0012429 obo:IAO_0000115 "Blood-forming tissue, consisting of reticular fibers and cells." ; obo:UBPROP_0000008 "Bone marrow in humans, kidney interstitium in Danio, within a stroma of reticuloendothelial tissue" ; oboInOwl:hasDbXref "CALOHA:TS-2142", "FMA:14073", "NCIT:C13051", "UMLS:C0229619" ; oboInOwl:hasExactSynonym "haemopoietic tissue", "hematopoietic tissue", "hemopoietic tissue", "textus haemopoieticus" ; oboInOwl:hasNarrowSynonym "bone marrow tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012429" ; a owl:Class ; rdfs:label "hematopoietic tissue" ; rdfs:subClassOf obo:UBERON_0034769, _:genid154715 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty core:site_of ; owl:someValuesFrom obo:GO_0030097 ] ) ] . obo:UBERON_0012430 obo:IAO_0000115 "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." ; oboInOwl:hasBroadSynonym "tunica fibrosa" ; oboInOwl:hasDbXref "FMA:58102", "SCTID:361318005", "Wikipedia:Fibrous_tunic_of_eyeball" ; oboInOwl:hasExactSynonym "fibrous layer of eyeball" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corneosclera", "fibrous tunic" ; oboInOwl:id "UBERON:0012430" ; a owl:Class ; rdfs:label "tunica fibrosa of eyeball" ; rdfs:subClassOf obo:UBERON_0004923, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000964 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001773 ] . obo:UBERON_0012437 obo:IAO_0000115 "An anatomical line that adjacent_to a epithelium and adjacent_to a mesenchyme." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012437" ; a owl:Class ; rdfs:label "epithelial-mesenchymal boundary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000483 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003104 ] ) ] . obo:UBERON_0012463 obo:IAO_0000115 "An anatomical space that is enclosed by a cloaca." ; obo:UBPROP_0000012 "the ZFA class belongs here as it is an anatomical space. See https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/102/" ; oboInOwl:hasDbXref "TAO:0000330", "ZFA:0000330" ; oboInOwl:hasExactSynonym "cloaca lumen", "cloacal chamber" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012463" ; a owl:Class ; rdfs:label "cloacal lumen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ], _:genid154744 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012464 obo:IAO_0000115 "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." ; oboInOwl:hasExactSynonym "cloacal opening" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cloacal orifice", "vent" ; oboInOwl:id "UBERON:0012464" ; a owl:Class ; rdfs:label "cloacal vent" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 _:genid152597 ) ] . obo:UBERON_0012465 obo:IAO_0000115 "An anatomical space that is enclosed by a terminal part of digestive tract." ; obo:UBPROP_0000008 "includes the cloacal lumen, in species where this is present" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012465" ; a owl:Class ; rdfs:label "lumen of terminal part of digestive tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006866 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0006866 ] ) ] . obo:UBERON_0012466 oboInOwl:hasDbXref "EHDAA2:0000472", "EMAPA:16054", "VHOG:0000767" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "extraembryonic cavities" ; oboInOwl:id "UBERON:0012466" ; a owl:Class ; rdfs:label "extraembryonic cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] ) ] . obo:UBERON_0012467 obo:IAO_0000115 "An anatomical space with no opening to another space or to the exterior." ; oboInOwl:hasDbXref "AEO:0000222" ; oboInOwl:hasExactSynonym "closed anatomical space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012467" ; a owl:Class ; rdfs:label "enclosed anatomical space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000608 ] ) ] . obo:UBERON_0012468 obo:IAO_0000115 "Triangular calcified papillae (often five) placed radially around the anus of some Holothuriidae." ; oboInOwl:hasExactSynonym "anal teeth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "calcified anal papilla", "cloacal tooth", "perianal tooth" ; oboInOwl:id "UBERON:0012468" ; a owl:Class ; rdfs:label "anal tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] ) ] . obo:UBERON_0012469 oboInOwl:hasDbXref "EHDAA2:0004589" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012469" ; a owl:Class ; rdfs:label "external anal region" ; rdfs:subClassOf obo:UBERON_0000481, _:genid154777 . obo:UBERON_0012475 obo:IAO_0000115 "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." ; oboInOwl:hasDbXref "FMA:24139" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bones of upper limb", "ossa membri superioris", "pectoral complex skeleton", "set of bones of upper limb", "skeleton of anterior limb/fin and girdle", "upper limb skeleton" ; oboInOwl:id "UBERON:0012475" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skeleton of pectoral complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ], _:genid154784 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_0012476 obo:IAO_0000115 "The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle." ; oboInOwl:hasDbXref "FMA:24140" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bones of lower limb", "lower limb skeleton", "ossa membri inferioris", "pelvic complex skeleton", "set of bones of lower limb", "skeleton of posterior limb/fin and girdle" ; oboInOwl:id "UBERON:0012476" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skeleton of pelvic complex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 ], _:genid154798 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_0012477 obo:IAO_0000115 "The posterior region of the neck, including the suboccipital region." ; obo:UBPROP_0000007 "nuchal" ; oboInOwl:hasBroadSynonym "nape" ; oboInOwl:hasDbXref "BTO:0000957", "FMA:24189", "SCTID:182326009", "SCTID:304036007" ; oboInOwl:hasExactSynonym "back of neck", "nape of neck", "neck back", "nucha", "nuchal region", "posterior cervical region", "posterior neck region", "posterior part of neck", "regio cervicalis posterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hindneck" ; oboInOwl:id "UBERON:0012477" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dorsal part of neck" ; rdfs:subClassOf obo:UBERON_0005434, _:genid154808, _:genid154810, _:genid154812 . obo:UBERON_0012478 obo:IAO_0000115 "A gland that is part of a cloaca." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012478" ; a owl:Class ; rdfs:label "cloacal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012480 obo:IAO_0000115 "A mucosa that is part of a cloaca [Automatically generated definition]." ; oboInOwl:hasAlternativeId "UBERON:0003349" ; oboInOwl:hasExactSynonym "cloaca mucosa", "cloaca mucosa of organ", "cloaca mucous membrane", "cloaca organ mucosa", "cloacal mucous membrane", "mucosa of cloaca", "mucosa of organ of cloaca", "mucous membrane of cloaca", "organ mucosa of cloaca" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012480" ; a owl:Class ; rdfs:label "cloacal mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152669 ] . obo:UBERON_0012481 obo:IAO_0000115 "An epithelium that is part of a cloaca." ; obo:UBPROP_0000001 "cloacal epithelium (cle) (syn: cloacal endoderm) (TS17-TS20): the cloacal epithelium is derived from endoderm and lines the cloacal cavity. It is marked by Shh and Cdh1 and lines the cloacal lumen. The cloacal epithelium gives rise to the urogenital sinus epithelium, hindgut epithelium and the urethral plate epithelium." ; oboInOwl:hasDbXref "EMAPA:27577", "EMAPA:36070", "ZFA:0005783" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cloacal endoderm" ; oboInOwl:id "UBERON:0012481" ; a owl:Class ; rdfs:label "cloacal epithelium" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012482 obo:IAO_0000115 "A submucosa that is part of a cloaca [Automatically generated definition]." ; oboInOwl:hasExactSynonym "cloaca submucosa", "cloacal submucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012482" ; a owl:Class ; rdfs:label "submucosa of cloaca" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012483 obo:IAO_0000115 "A serous membrane that is part of a cloaca [Automatically generated definition]." ; oboInOwl:hasExactSynonym "cloaca serosa", "cloaca serous membrane", "cloacal serosa", "serous membrane of cloaca", "visceral peritoneum of cloaca" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012483" ; a owl:Class ; rdfs:label "serosa of cloaca" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012485 oboInOwl:hasExactSynonym "cloacal villi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012485" ; a owl:Class ; rdfs:label "cloacal villus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0012486 obo:IAO_0000115 "A muscular coat that is part of a cloaca." ; oboInOwl:hasExactSynonym "muscularis externa of cloaca" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "smooth muscle of cloaca" ; oboInOwl:id "UBERON:0012486" ; a owl:Class ; rdfs:label "muscle layer of cloaca" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid152697 ] . obo:UBERON_0012487 obo:IAO_0000115 "A sphincter muscle that is part of a vagina." ; oboInOwl:hasExactSynonym "sphincter of vagina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012487" ; a owl:Class ; rdfs:label "vaginal sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0012488 obo:IAO_0000115 "A muscular coat that is part of a duodenum." ; oboInOwl:hasDbXref "FMA:14944", "SCTID:362147007" ; oboInOwl:hasExactSynonym "duodenal muscularis propria", "muscularis externa of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscularis propria of duodenum", "smooth muscle of duodenum" ; oboInOwl:id "UBERON:0012488" ; a owl:Class ; rdfs:label "muscle layer of duodenum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0012489 obo:IAO_0000115 "A muscular coat that is part of a colon." ; oboInOwl:hasDbXref "EMAPA:27383", "FMA:14986", "MA:0003198", "SCTID:362158003" ; oboInOwl:hasExactSynonym "colonic muscularis propria", "muscular coat of colon", "muscular layer of colon", "muscularis externa of colon", "tunica muscularis coli" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "colon muscularis" ; oboInOwl:id "UBERON:0012489" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "muscle layer of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0012490 obo:IAO_0000115 "A muscular coat that is part of a anal canal." ; oboInOwl:hasDbXref "FMA:15708", "SCTID:362171000" ; oboInOwl:hasExactSynonym "anal canal muscularis propria", "anal muscularis propria", "muscular coat of anal canal", "muscular layer of anal canal", "muscularis externa of anal canal", "muscularis propria of anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012490" ; a owl:Class ; rdfs:label "muscle layer of anal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0012499 obo:IAO_0000115 "A serous membrane that is part of a fallopian tube." ; oboInOwl:hasDbXref "FMA:18316", "SCTID:259593000" ; oboInOwl:hasExactSynonym "serosa of fallopian tube", "serosa of oviduct", "serous coat of uterine tube", "tunica serosa (tuba uterina)", "tunica serosa tubae uterinae", "uterine tubal serosa", "uterine tube serosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012499" ; a owl:Class ; rdfs:label "serosa of uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_0012504 obo:IAO_0000115 "An adventitia that is part of a esophagus." ; oboInOwl:hasDbXref "FMA:63006", "SCTID:85950006" ; oboInOwl:hasExactSynonym "adventitia of oesophagus", "adventitious layer of esophagus", "esophageal adventitia", "esophagus adventitia", "tunica adventitia (esophagus)", "tunica adventitia oesophageae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012504" ; a owl:Class ; rdfs:label "adventitia of esophagus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005742 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0012615 obo:IAO_0000115 "A smooth muscle tissue that is part of a umbilical cord." ; oboInOwl:hasDbXref "BTO:0001847" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012615" ; a owl:Class ; rdfs:label "umbilical smooth muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:UBERON_0012650 obo:IAO_0000115 "An anatomical junction that connects a stomach and connects a duodenum." ; oboInOwl:hasDbXref "FMA:17046", "SCTID:264014000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012650" ; a owl:Class ; rdfs:label "gastroduodenal junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 _:genid152763 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0012651 obo:IAO_0000115 "A mucosa that is part of a gastroduodenal junction." ; oboInOwl:hasDbXref "BTO:0005415" ; oboInOwl:hasExactSynonym "gastroduodenal mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0012651" ; a owl:Class ; rdfs:label "mucosa of gastroduodenal junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001199 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012650 ] ) ] . obo:UBERON_0013069 obo:IAO_0000115 "A depression on the ventral side of the femur, at the knee joint, between the condyles." ; oboInOwl:hasDbXref "FMA:22525", "NCIT:C103222", "SCTID:362791002", "Wikipedia:Popliteal_fossa", "http://palaeos.com/vertebrates/glossary/images/popliteal.gif" ; oboInOwl:hasExactSynonym "popliteal fossa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "knee pit", "popliteal region", "popliteal space" ; oboInOwl:id "UBERON:0013069" ; a owl:Class ; rdfs:label "popliteal area" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] . obo:UBERON_0013118 obo:IAO_0000115 "A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals." ; obo:IAO_0000116 "sulci are considered absent from lissencephalic mammals such as mice, but they may possess fissures. For example, the Allen mouse brain Atlas includes hippocampal, rhinal and choroid fissure. For this reason we do not place a taxon constraint on this class" ; obo:UBPROP_0000001 "Indentation on the surface of the brain or spinal cord that forms a recognizable landmark, e.g., central sulcus, sulcus limitans (CUMBO)" ; oboInOwl:hasBroadSynonym "sulci & spaces", "sulcus" ; oboInOwl:hasDbXref "DHBA:10610", "HBA:9352", "NCIT:C32292", "SCTID:279337001", "Wikipedia:Sulcus_(neuroanatomy)", "neuronames:1208" ; oboInOwl:hasExactSynonym "cerebral sulci" ; oboInOwl:hasNarrowSynonym "fissure of brain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebral sulci", "cerebral sulcus" ; oboInOwl:id "UBERON:0013118" ; oboInOwl:inSubset core:cumbo ; a owl:Class ; rdfs:label "sulcus of brain" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000200 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000093 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0013121 oboInOwl:hasDbXref "FMA:32888" ; oboInOwl:hasExactSynonym "basal epiphysis of phalanx of foot", "base of phalanx of foot", "basis phalangis (pedis)", "basis phalangis pedis", "proximal epiphysis of phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013121" ; a owl:Class ; rdfs:label "proximal epiphysis of phalanx of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] . obo:UBERON_0013122 oboInOwl:hasDbXref "FMA:32890", "SCTID:236801009" ; oboInOwl:hasExactSynonym "caput phalangis (pedis)", "caput phalangis pedis", "distal end of phalanx of foot", "distal epiphysis of phalanx of toe", "head of phalanx of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of toe" ; oboInOwl:id "UBERON:0013122" ; a owl:Class ; rdfs:label "distal epiphysis of phalanx of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001449 ] ) ] . obo:UBERON_0013124 obo:IAO_0000115 "A posterior cardinal vein that is in_the_left_side_of a multicellular organism." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EHDAA2:0001486", "FMA:70316", "SCTID:361504002" ; oboInOwl:hasExactSynonym "left postcardinal vein", "posterior cardinal vein left" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013124" ; a owl:Class ; rdfs:label "left posterior cardinal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002065 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0013126 obo:IAO_0000115 "A vein that is part of a abdomen." ; obo:IAO_0000116 "TODO mirror representation of abdominal aorta" ; obo:IAO_0000232 "this class groups all veins that are in the abdomen. The term 'abdominal vein' may have specific meanings in different contexts. The lateral abdominal veins are present in fishes but usually merged or absent in tetrapods; in amphibians, the L&R abdominal veins merge into the ventral abdominal vein" ; oboInOwl:hasDbXref "SCTID:281473003" ; oboInOwl:hasExactSynonym "abdominal vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013126" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "vein of abdomen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0013135 obo:IAO_0000115 "The interdental plate refers to the bone-filled mesial-distal region between the teeth." ; obo:UBPROP_0000008 "In paleobiology, the presence or absence of the interdental plate can determine the place of an animal in the evolutionary scale, and paleontologists use the interdental plate when trying to classify a new specimen. Thecodont reptiles and theropod dinosaur fossils have an interdental plate, whereas acrodont reptiles such as Sphenodontia do not.[3] Its presence in Archaeopteryx, an extinct avian, resulted in the proposal of the dinosaur-bird connection" ; oboInOwl:hasDbXref "Wikipedia:Interdental_plate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013135" ; a owl:Class ; rdfs:label "interdental plate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001708 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005913 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0012111 ] ) ] . obo:UBERON_0013136 obo:IAO_0000115 "A vein that drains a lip." ; oboInOwl:hasDbXref "SCTID:367664002" ; oboInOwl:hasExactSynonym "labial vein of face", "lip vein", "vena labialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "labial vein" ; oboInOwl:id "UBERON:0013136" ; a owl:Class ; rdfs:label "vein of lip" ; rdfs:subClassOf _:genid154996 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0013139 obo:IAO_0000115 "A nonskeletal ligament that is part of a liver." ; oboInOwl:hasDbXref "FMA:15820", "NCIT:C32997", "SCTID:48536008", "UMLS:C0230238" ; oboInOwl:hasExactSynonym "hepatic ligament", "liver ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013139" ; a owl:Class ; rdfs:label "ligament of liver" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008845 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0013140 obo:IAO_0000115 "Any vein within the general circulation that transports blood back to the right atrium of the heart." ; oboInOwl:hasDbXref "FMA:66644", "NCIT:C33719", "SCTID:244389004", "UMLS:C0447117" ; oboInOwl:hasExactSynonym "systemic venous tree organ part" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013140" ; a owl:Class ; rdfs:label "systemic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004581 ] ) ] . obo:UBERON_0013142 obo:IAO_0000115 "A vein that drains the soleus." ; oboInOwl:hasDbXref "SCTID:397427005" ; oboInOwl:hasExactSynonym "soleus vein", "vein of soleus muscle", "vena solealis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013142" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "soleal vein" ; rdfs:subClassOf obo:UBERON_0001551, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001546 ], _:genid155021 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001389 ] ) ] . obo:UBERON_0013143 obo:IAO_0000115 "A vein that drains the gastrocnemius." ; oboInOwl:hasDbXref "SCTID:264481007" ; oboInOwl:hasExactSynonym "vein of gastrocnemius muscle", "vena gastrocnemii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013143" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "divided in medial gastrocnemius vein (vena medialis gastrocnemii), lateral gastrocnemius vein (vena lateralis gastrocnemii), and intergemellar vein (Vena intergemellaris), the vein ascending between the two heads of the gastrocnemius[http://www.veinsurg.com/fr/biblio/echodoppler/echodoppler_11.php]" ; rdfs:label "gastrocnemius vein" ; rdfs:subClassOf obo:UBERON_0001551, _:genid155030 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001388 ] ) ] . obo:UBERON_0013147 oboInOwl:hasDbXref "EHDAA2:0001102" ; oboInOwl:hasExactSynonym "mesencephalic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013147" ; a owl:Class ; rdfs:comment "gives rise to midbrain vesicle which gives rise to cerebral aqueduct" ; rdfs:label "early mesencephalic vesicle" ; rdfs:subClassOf obo:UBERON_0013150, _:genid155034 . obo:UBERON_0013148 oboInOwl:hasDbXref "EHDAA2:0001103", "SCTID:361481005" ; oboInOwl:hasExactSynonym "midbrain vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013148" ; a owl:Class ; rdfs:comment "develops into cerebral aqueduct" ; rdfs:label "early midbrain vesicle" ; rdfs:subClassOf obo:UBERON_0013150, _:genid155037, _:genid155039 . obo:UBERON_0013149 oboInOwl:hasDbXref "EHDAA2:0000101", "SCTID:361482003" ; oboInOwl:hasExactSynonym "rhombencephalic vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013149" ; a owl:Class ; rdfs:comment "gives rise of 4th ventricle" ; rdfs:label "hindbrain vesicle" ; rdfs:subClassOf obo:UBERON_0013150, _:genid155042 . obo:UBERON_0013150 obo:IAO_0000116 "consider adding all secondary vesicles (e.g. diencephalic; my/metencephalic. See http://www.dartmouth.edu/~rswenson/NeuroSci/chapter_4.html)." ; obo:UBPROP_0000012 "Note that some sources may treat the term vesicle as the progenitor of the whole brain region; for example 'The retina develops directly from the neural tube as an outpouching from the diencephalic vesicle'" ; oboInOwl:hasDbXref "NCIT:C34259", "SCTID:360409004", "neuronames:2499" ; oboInOwl:hasExactSynonym "early brain vesicle", "primitive brain vesicle" ; oboInOwl:hasNarrowSynonym "primary brain vesicle", "secondary brain vesicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain vesicle" ; oboInOwl:id "UBERON:0013150" ; a owl:Class ; rdfs:label "future brain vesicle" ; rdfs:subClassOf obo:UBERON_0010064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006238 ], _:genid155047 . obo:UBERON_0013151 obo:IAO_0000115 "One of two arteries (anterior and posterior choroidal artery) that supply blood to the choroid plexus, optic tract, hippocampus, globus pallidus, and other various brain regions." ; oboInOwl:hasDbXref "NCIT:C32310", "SCTID:244210009", "UMLS:C0226164" ; oboInOwl:hasExactSynonym "artery of choroid plexus", "choroid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013151" ; a owl:Class ; rdfs:label "choroidal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001886 ] ) ] . obo:UBERON_0013156 oboInOwl:hasDbXref "EHDAA2:0000033", "EMAPA:16384" ; oboInOwl:hasExactSynonym "endoderm of mandibular component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013156" ; a owl:Class ; rdfs:label "1st arch mandibular endoderm" ; rdfs:subClassOf obo:UBERON_0000490, _:genid155057, _:genid155059, _:genid155061, _:genid155063 . obo:UBERON_0013158 obo:IAO_0000115 "A gland that is part of a foregut-midgut junction." ; oboInOwl:hasDbXref "EHDAA2:0000574", "EMAPA:17065" ; oboInOwl:hasExactSynonym "gland of foregut-midgut junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013158" ; a owl:Class ; rdfs:label "foregut-midgut junction gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 ] ) ] . obo:UBERON_0013159 oboInOwl:hasDbXref "EHDAA2:0000449", "EHDAA:5435", "EMAPA:17533", "VHOG:0000913" ; oboInOwl:hasExactSynonym "mantle layer epithalamus", "mantle layer of epithalamus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013159" ; a owl:Class ; rdfs:label "epithalamus mantle layer" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009580 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001899 ] ) ] . obo:UBERON_0013160 oboInOwl:hasDbXref "EHDAA2:0000450", "EHDAA:5437", "EMAPA:17535", "VHOG:0000884" ; oboInOwl:hasExactSynonym "ventricular layer epithalamus", "ventricular layer of epithalamus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013160" ; a owl:Class ; rdfs:label "epithalamus ventricular layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001899 ] ) ] . obo:UBERON_0013161 obo:IAO_0000115 "A telencephalic ventricle that is in_the_left_side_of a telencephalon." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:78450", "SCTID:368593005" ; oboInOwl:hasExactSynonym "left telencephalic ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013161" ; a owl:Class ; rdfs:label "left lateral ventricle" ; rdfs:subClassOf _:genid155087 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002285 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0013162 obo:IAO_0000115 "A telencephalic ventricle that is in_the_right_side_of a telencephalon." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:78449", "SCTID:368571000" ; oboInOwl:hasExactSynonym "right telencephalic ventricle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013162" ; a owl:Class ; rdfs:label "right lateral ventricle" ; rdfs:subClassOf _:genid155094 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002285 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0013164 obo:IAO_0000115 "A molar or premolar." ; oboInOwl:hasExactSynonym "postcanine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cheek tooth", "molariform" ; oboInOwl:id "UBERON:0013164" ; a owl:Class ; rdfs:label "molariform tooth" ; rdfs:subClassOf obo:UBERON_0001091, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006844 ] . obo:UBERON_0013167 obo:IAO_0000115 "Laryngeal ligament that connects the cricoid cartilage to the pharynx[WP,modified]." ; oboInOwl:hasDbXref "FMA:55260", "SCTID:172455006", "Wikipedia:Cricopharyngeal_ligament" ; oboInOwl:hasExactSynonym "crico-pharyngeal ligament", "ligamentum cricopharyngeum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013167" ; a owl:Class ; rdfs:label "cricopharyngeal ligament" ; rdfs:subClassOf obo:UBERON_0001730 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001743 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] . obo:UBERON_0013168 obo:IAO_0000115 "Laryngeal ligament that connects the epiglottis to the thyroid cartilage[WP,modified]." ; oboInOwl:hasDbXref "FMA:55230", "NCIT:C33777", "SCTID:279562000", "UMLS:C0225514", "Wikipedia:Thyroepiglottic_ligament" ; oboInOwl:hasExactSynonym "ligamentum thyroepiglotticum", "thyroepiglottic ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013168" ; a owl:Class ; rdfs:label "thyroepiglottic ligament" ; rdfs:subClassOf obo:UBERON_0006325 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001743 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001742 ] ) ] . obo:UBERON_0013170 obo:IAO_0000115 "Laryngeal ligament that connects the cricoid and arytenoid cartilages[WP,modified]." ; oboInOwl:hasDbXref "FMA:55261", "SCTID:172533001", "Wikipedia:Cricoarytenoid_ligament" ; oboInOwl:hasExactSynonym "crico-arytenoid ligament", "ligamentum cricoaryteneoideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013170" ; a owl:Class ; rdfs:label "cricoarytenoid ligament" ; rdfs:subClassOf obo:UBERON_0001730 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001743 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001740 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] . obo:UBERON_0013171 obo:IAO_0000115 "This attaches the caudal border of the thyroid cartilage to the ventral arch of the cricoid cartilage. Its sheetlike ventral portion is sometimes referred to as the cricothyroid membrane. Being elastic, it 'balances' movement at the hinge-like cricothyroid joint and determines the resting position of the larynx when the muscles are relaxed[MURDOCH]. The cricothyroid ligament is the larger part of the laryngeal membrane, continuing inferiorly as a median or anterior part and twin lateral ligaments. The median cricothyroid ligament is a flat band of white tissue joining the cricoid and thyroid cartilages, while the lateral cricothyroid ligament is also known as the cricothyroid membrane (also called conus elasticus)." ; oboInOwl:hasDbXref "FMA:55233", "NCIT:C32403", "SCTID:279558006", "UMLS:C0225542", "Wikipedia:Cricothyroid_ligament" ; oboInOwl:hasExactSynonym "crico-thyroid ligament", "ligamentum cricothyreoideum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013171" ; a owl:Class ; rdfs:label "cricothyroid ligament" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001743 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001738 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] ) ] . obo:UBERON_0013172 obo:IAO_0000115 "The cricotracheal ligament connects the cricoid cartilage with the first ring of the trachea[WP]. The caudal border of the cricoid cartilage is joined to the first ring of the trachea by this ligament. It is an extrinsic laryngeal ligament. It resembles the fibrous membrane which connects the cartilaginous rings of the trachea to each other." ; oboInOwl:hasDbXref "FMA:55259", "NCIT:C32405", "SCTID:279553002", "UMLS:C0225543", "Wikipedia:Cricotracheal_ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013172" ; a owl:Class ; rdfs:label "cricotracheal ligament" ; rdfs:subClassOf obo:UBERON_0001730 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001743 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002375 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003604 ] ) ] . obo:UBERON_0013191 obo:IAO_0000115 "The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles." ; oboInOwl:hasDbXref "EMAPA:37927", "FMA:18613", "NCIT:C33243", "UMLS:C0227878" ; oboInOwl:hasExactSynonym "cortex of ovary", "cortex ovarii (zona parenchymatosa)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013191" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "ovarian cortex" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006960 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0013192 obo:IAO_0000115 "Highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles." ; obo:UBPROP_0000010 "composed of loose connective tissue that contains blood vessels, lymph vessels and nerves" ; oboInOwl:hasDbXref "EMAPA:37928", "FMA:18616", "NCIT:C33245", "UMLS:C0227879", "Wikipedia:Medulla_of_ovary" ; oboInOwl:hasExactSynonym "medulla of ovary", "medulla ovarii (zona vasculosa)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "zona vasculosa of Waldeyer" ; oboInOwl:id "UBERON:0013192" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ovarian medulla" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000992 ] ) ] . obo:UBERON_0013228 obo:IAO_0000115 "Glands of Moll, also known as ciliary glands, are modified apocrine sweat glands that are found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the Meibomian glands within the distal eyelid margin. These glands are relatively large and tubular-shaped. The glands of Moll are named after Dutch oculist Jacob Anton Moll (1832-1914). Glands of Moll empty into the adjacent lashes. Glands of Moll and Zeis secrete lipid that adds to the superficial layer of the tear film, retarding evaporation. The glands of Moll are prone to infection and blockage of its duct with sebum and cell debris. Blockage of the gland's duct causes swelling which can manifest itself as a stye." ; oboInOwl:hasDbXref "FMA:59159", "NCIT:C32679", "SCTID:280586002", "Wikipedia:Gland_of_Moll" ; oboInOwl:hasExactSynonym "Moll's gland", "ciliary gland", "ciliary gland of moll", "ciliary sweat gland of eyelid", "gland of Moll" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013228" ; a owl:Class ; rdfs:label "sweat gland of eyelid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000382 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0013229 obo:IAO_0000115 "Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland)." ; oboInOwl:hasDbXref "SCTID:280574000" ; oboInOwl:hasExactSynonym "gland of eyelid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013229" ; a owl:Class ; rdfs:label "eyelid gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0013231 obo:IAO_0000115 "Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013231" ; a owl:Class ; rdfs:label "sebaceous gland of eyelid" ; owl:equivalentClass _:genid153011 . obo:UBERON_0013232 obo:IAO_0000115 "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." ; oboInOwl:hasDbXref "FMA:86279" ; oboInOwl:hasExactSynonym "acinus of serous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013232" ; a owl:Class ; rdfs:label "serous acinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000313 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000409 ] ) ] . obo:UBERON_0013235 obo:IAO_0000115 "A major organism subdivisionthat is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane." ; obo:UBPROP_0000007 "ventral" ; oboInOwl:hasBroadSynonym "front", "ventral region" ; oboInOwl:hasDbXref "FMA:259204" ; oboInOwl:hasExactSynonym "front of body proper", "ventral part of organism", "ventral region of organism" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013235" ; a owl:Class ; rdfs:label "ventrum" ; rdfs:subClassOf obo:UBERON_0000475 . obo:UBERON_0013238 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013238" ; a owl:Class ; rdfs:label "future glans" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011757 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0035651 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0013239 obo:UBERON_0013240 ) ] . obo:UBERON_0013239 obo:IAO_0000115 "A future glans that is part of a male genital tubercle." ; oboInOwl:hasDbXref "EMAPA:29252" ; oboInOwl:hasExactSynonym "glans of male genital tubercle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013239" ; a owl:Class ; rdfs:label "future glans penis" ; rdfs:subClassOf _:genid155208 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013238 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006261 ] ) ] . obo:UBERON_0013240 obo:IAO_0000115 "A future glans that is part of a female genital tubercle." ; oboInOwl:hasDbXref "EMAPA:19170" ; oboInOwl:hasExactSynonym "glans of female genital tubercle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013240" ; a owl:Class ; rdfs:label "future glans clitoris" ; rdfs:subClassOf _:genid155215 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013238 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006233 ] ) ] . obo:UBERON_0013241 obo:IAO_0000115 "The precursor of the urethra." ; obo:UBPROP_0000008 "In humans, the urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. It typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week" ; oboInOwl:hasDbXref "SCTID:361531004", "Wikipedia:Urethral_groove" ; oboInOwl:hasExactSynonym "sulcus urethralis primarius", "urethral groove", "urethral sulcus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013241" ; a owl:Class ; rdfs:label "embryonic urethral groove" ; rdfs:subClassOf obo:UBERON_0002050, _:genid155218 . obo:UBERON_0013247 obo:IAO_0000115 "An epithelial tube that develops from a Mullerian duct in a male. Later degenerates." ; obo:IAO_0000116 "consider separating the duct from the degenerating portion, as in EMAPA" ; oboInOwl:hasDbXref "EHDAA2:0001052", "EMAPA:29161", "EMAPA:35661" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "degenerating mesonephric portion of male paramesonephric duct" ; oboInOwl:id "UBERON:0013247" ; a owl:Class ; rdfs:label "male paramesonephric duct" ; rdfs:subClassOf _:genid155229, _:genid155231 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003890 ] ) ] . obo:UBERON_0013279 obo:IAO_0000115 "A diaphysis that is part of a fibula[Automatically generated definition]." ; obo:UBPROP_0000001 "The body of fibula presents four borders - the antero-lateral, the antero-medial, the postero-lateral, and the postero-medial; and four surfaces - anterior, posterior, medial, and lateral[Wikipedia:Body_of_fibula]." ; oboInOwl:hasDbXref "EMAPA:37892", "FMA:33738", "SCTID:302528006", "Wikipedia:Body_of_fibula" ; oboInOwl:hasExactSynonym "body of fibula", "corpus fibulae", "fibula diaphysis", "shaft of fibula" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013279" ; a owl:Class ; rdfs:label "diaphysis of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0013280 obo:IAO_0000115 "A diaphysis that is part of a tibia." ; obo:UBPROP_0000001 "The body of the tibia has three borders and three surfaces[Wikipedia:Body_of_tibia]." ; oboInOwl:hasDbXref "EMAPA:37770", "FMA:33125", "MA:0003049", "SCTID:302525009", "Wikipedia:Body_of_tibia" ; oboInOwl:hasExactSynonym "body of tibia", "corpus tibiae", "shaft of tibia", "tibial diaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body of the tibia", "shaft of tibia" ; oboInOwl:id "UBERON:0013280" ; a owl:Class ; rdfs:label "diaphysis of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0013411 obo:IAO_0000115 "Anatomical cavity that is the lumen of the skull and contains the brain." ; oboInOwl:hasDbXref "EMAPA:37497", "FMA:9644", "MA:0003061", "NCIT:C77638", "SCTID:264452006", "UMLS:C0230041", "Wikipedia:Cranial_cavity", "neuronames:2806" ; oboInOwl:hasExactSynonym "cavitas cranii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intracranial cavity", "intracranial space" ; oboInOwl:id "UBERON:0013411" ; a owl:Class ; rdfs:label "cranial cavity" ; rdfs:subClassOf _:genid155263 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg"^^xsd:anyURI . obo:UBERON_0013424 obo:IAO_0000115 "The occipital angle is rounded and corresponds with the point of meeting of the sagittal and lambdoidal sutures-a point which is termed the lambda (after the Greek letter of the same name); in the fetus this part of the skull is membranous, and is called the posterior fontanelle." ; oboInOwl:hasBroadSynonym "lambda" ; oboInOwl:hasDbXref "FMA:264773", "Wikipedia:Lambda_(anatomy)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior fontanelle" ; oboInOwl:id "UBERON:0013424" ; a owl:Class ; rdfs:label "anatomical point connecting sagittal and lambdoidal sutures" ; rdfs:subClassOf _:genid155277 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006983 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002491 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002492 ] ) ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray1193.svg"^^xsd:anyURI . obo:UBERON_0013455 obo:IAO_0000115 "The sphenopetrosal fissure (or sphenopetrosal suture) is the cranial suture between the sphenoid bone and the petrous portion of the temporal bone. It is in the middle cranial fossa." ; oboInOwl:hasDbXref "FMA:75038", "Wikipedia:Sphenopetrosal_fissure" ; oboInOwl:hasExactSynonym "fissura sphenopetrosa", "sphenopetrosal fissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013455" ; a owl:Class ; rdfs:label "spheno-petrosal fissure" ; rdfs:subClassOf _:genid155288 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid153101 ] ; foaf:depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png"^^xsd:anyURI . obo:UBERON_0013472 obo:IAO_0000115 "The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type." ; oboInOwl:hasDbXref "NCIT:C12253", "SCTID:276801001", "UMLS:C0227187" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal part of esophagus", "upper third of esophagus" ; oboInOwl:id "UBERON:0013472" ; a owl:Class ; rdfs:label "upper esophagus" ; rdfs:subClassOf obo:UBERON_0004921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] . obo:UBERON_0013475 obo:IAO_0000115 "A serous salivary gland which resides adjacent to the moats surrounding the circumvallate papillae in the posterior one-third of the tongue, anterior to the terminal sulcus." ; obo:UBPROP_0000009 "posterior deep lingual glands produce lingual lipase, which hydrolyzes triacylglycerols in the acidic gastric lumen, the first step in the digestion of dietary fat (Hamosh & Scow, 1973; Hamosh & Burns, 1977). In view of their close proximity to the lingual lymphatic tissues, the glands were also thought to be involved in antimicrobial action and local immune response (Nair & Schroeder, 1983)[PMCID:PMC2667924]" ; obo:UBPROP_0000010 "a group of tubulo-acinar serous glands located beneath the circumvallate and foliate papillae of the tongue and their ducts open into the trough at the base of the papillae. The saliva from posterior deep lingual glands is known to modulate the microenvironment at taste reception sites, and affect chemoreception (Gurkan & Bradley, 1988) and it is an important source of growth factors for taste receptor cells (Morris-Wiman et al. 2000)[PMCID:PMC2667924]" ; oboInOwl:hasDbXref "FMA:293448", "Wikipedia:Von_Ebner's_gland" ; oboInOwl:hasExactSynonym "posterior deep lingual gland", "posterior lingual serous gland", "von Ebner gland", "von Ebner's gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013475" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "gustatory gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001044 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010033 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000313 ] ) ] . obo:UBERON_0013479 obo:IAO_0000115 "A blood vessel endothelium that is part of a lung [Automatically generated definition]." ; oboInOwl:hasDbXref "BTO:0004128", "CALOHA:TS-0573" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "respiratory endothelium" ; oboInOwl:id "UBERON:0013479" ; a owl:Class ; rdfs:label "lung endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0013491 obo:IAO_0000115 "Any fascia tissue that is part of the neck region." ; oboInOwl:hasDbXref "FMA:76866", "SCTID:361906006", "Wikipedia:Cervical_fascia" ; oboInOwl:hasExactSynonym "fascia of neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013491" ; a owl:Class ; rdfs:label "cervical fascia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0013493 obo:IAO_0000115 "A fascia that is part of a abdomen." ; oboInOwl:hasDbXref "FMA:19841", "SCTID:306708007", "Wikipedia:Abdominal_fascia" ; oboInOwl:hasExactSynonym "endo-abdominopelvic fascia", "fascia of abdomen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013493" ; a owl:Class ; rdfs:label "abdominal fascia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0013498 obo:IAO_0000116 "requires verification" ; oboInOwl:hasDbXref "EHDAA2:0004313", "EMAPA:17570" ; oboInOwl:hasExactSynonym "vestibulocochlear VIII ganglion complex", "vestibulocochlear ganglion complex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vestibular VIII ganglion complex" ; oboInOwl:id "UBERON:0013498" ; a owl:Class ; rdfs:label "vestibulo-cochlear VIII ganglion complex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001714 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001648 ] ) ] . obo:UBERON_0013501 obo:IAO_0000115 "A sphincter muscle that is part of a cloaca." ; oboInOwl:hasDbXref "NCIT:C34129", "UMLS:C1516658" ; oboInOwl:hasExactSynonym "sphincter cloacae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013501" ; a owl:Class ; rdfs:comment "the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938)." ; rdfs:label "cloacal sphincter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0013503 obo:IAO_0000115 "A caudal vertebra endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasAlternativeId "UBERON:0013517" ; oboInOwl:hasDbXref "EHDAA2:0000260", "EMAPA:18044" ; oboInOwl:hasExactSynonym "coccygeal vertebra cartilage element", "coccygeal vertebral cartilage condensation group", "tail vertebral cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013503" ; a owl:Class ; rdfs:label "caudal vertebra cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006076 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013504 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001095 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid153155 ] . obo:UBERON_0013504 obo:IAO_0000115 "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasAlternativeId "UBERON:0013518" ; oboInOwl:hasDbXref "EMAPA:18045" ; oboInOwl:hasExactSynonym "coccygeal vertebra pre-cartilage condensation", "tail vertebral pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013504" ; a owl:Class ; rdfs:label "caudal vertebra pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006076 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018142 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0013505 obo:IAO_0000115 "A cervical vertebra endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0000240" ; oboInOwl:hasExactSynonym "cervical vertebral cartilage condensation group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013505" ; a owl:Class ; rdfs:label "cervical vertebra cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013506 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002413 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015007 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0013506 obo:IAO_0000115 "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013506" ; a owl:Class ; rdfs:label "cervical vertebra pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015007 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0013507 obo:IAO_0000115 "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0002014" ; oboInOwl:hasExactSynonym "thoracic vertebral cartilage condensation group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013507" ; a owl:Class ; rdfs:label "thoracic vertebra cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ], _:genid153191, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002347 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015008 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0013508 obo:IAO_0000115 "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013508" ; a owl:Class ; rdfs:label "thoracic vertebra pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015008 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0013509 obo:IAO_0000115 "A lumbar vertebra endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "EHDAA2:0001038" ; oboInOwl:hasExactSynonym "lumbar vertebral cartilage condensation group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013509" ; a owl:Class ; rdfs:label "lumbar vertebra cartilage element" ; rdfs:subClassOf _:genid153205, [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002414 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015009 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0013510 obo:IAO_0000115 "A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013510" ; a owl:Class ; rdfs:label "lumbar vertebra pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015009 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0013514 obo:IAO_0000115 "The space that surrounds an organism." ; oboInOwl:hasExactSynonym "external to organism", "outside of body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013514" ; a owl:Class ; rdfs:label "space surrounding organism" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0013515 obo:IAO_0000115 "A section through the tube or network of tubes that connects the ovaries to the outside of the body." ; obo:UBPROP_0000012 "FMA class may only represent the uterine portion" ; oboInOwl:hasDbXref "FMA:18302" ; oboInOwl:hasExactSynonym "subdivision of oviduct", "subdivision of uterine tube", "uterine tube zone", "zone of uterine tube" ; oboInOwl:hasNarrowSynonym "subdivision of fallopian tube" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013515" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of oviduct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000993 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0000993 ] ) ] . obo:UBERON_0013522 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013522" ; a owl:Class ; rdfs:label "subdivision of tube" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000025 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000060 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000464 ], [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0000025 ] . obo:UBERON_0013525 obo:IAO_0000115 "The anatomical space that is enclosed by a stomach." ; obo:UBPROP_0000001 "Organ cavity which is bound by the internal surface of the wall of stomach. Examples: There is only one cavity of stomach[FMA:14585]." ; oboInOwl:hasDbXref "EMAPA:18395", "FMA:14585" ; oboInOwl:hasExactSynonym "cavity of stomach" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gastric cavity" ; oboInOwl:id "UBERON:0013525" ; a owl:Class ; rdfs:label "stomach lumen" ; rdfs:subClassOf _:genid155421 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000945 ] ) ] . obo:UBERON_0013526 obo:IAO_0000115 "An anatomical cavity that is part of a ear vesicle." ; oboInOwl:hasDbXref "EHDAA2:0004121", "EMAPA:25363" ; oboInOwl:hasExactSynonym "lumen of otocyst" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013526" ; a owl:Class ; rdfs:label "otocyst lumen" ; rdfs:subClassOf obo:UBERON_0007473, _:genid155432, _:genid155434 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003051 ] ) ] . obo:UBERON_0013581 obo:IAO_0000115 "A metapodium bone that is part of a digit 1 plus metapodial segment." ; oboInOwl:hasExactSynonym "metapodium 1", "metapodium I" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013581" ; a owl:Class ; rdfs:label "metapodium bone 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006048 ] ) ] . obo:UBERON_0013582 obo:IAO_0000115 "A metapodium bone that is part of a digit 2 plus metapodial segment." ; oboInOwl:hasExactSynonym "metapodium 2", "metapodium II" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013582" ; a owl:Class ; rdfs:label "metapodium bone 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006049 ] ) ] . obo:UBERON_0013583 obo:IAO_0000115 "A metapodial bone that is associated with digit III." ; oboInOwl:hasExactSynonym "3rd metapodium bone", "metapodial bone III", "metapodium 3", "metapodium III" ; oboInOwl:hasNarrowSynonym "cannon bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013583" ; a owl:Class ; rdfs:label "metapodium bone 3" ; owl:equivalentClass _:genid153262 . obo:UBERON_0013584 obo:IAO_0000115 "A metapodium bone that is part of a digit 4 plus metapodial segment." ; oboInOwl:hasExactSynonym "metapodium 4", "metapodium IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013584" ; a owl:Class ; rdfs:label "metapodium bone 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006051 ] ) ] . obo:UBERON_0013585 obo:IAO_0000115 "A metapodium bone that is part of a digit 5 plus metapodial segment." ; oboInOwl:hasExactSynonym "metapodium 5", "metapodium V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013585" ; a owl:Class ; rdfs:label "metapodium bone 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid153276 ] . obo:UBERON_0013586 obo:IAO_0000115 "An element formed from the fusion of metapodium 3 and metapodium 4 (i.e. either metatarsals 3 and 4 or metacarpals 3 and 4)." ; obo:IAO_0000232 "this class can be used in annotation when it is unclear whether the element is a fusion of the metacarpal and metatarsal elements." ; oboInOwl:hasExactSynonym "fused metapodials 3/4", "os metapodiale III et IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metapodial 3+4" ; oboInOwl:id "UBERON:0013586" ; a owl:Class ; rdfs:label "fused metapodial bones 3 and 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0013583 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0013584 ] ) ] . obo:UBERON_0013587 obo:IAO_0000115 "An element formed from the fusion of metacarpal 3 and metacarpal 4." ; obo:UBPROP_0000008 "In many artiodactyls, the 3rd & 4th metapodials are fused, creating a main metapodial." ; oboInOwl:hasExactSynonym "fused metacarpal 3/4", "os metacarpale III et IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metacarpal 3+4" ; oboInOwl:id "UBERON:0013587" ; a owl:Class ; rdfs:label "fused metacarpal bones 3 and 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002374 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003647 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003648 ] ) ] . obo:UBERON_0013588 obo:IAO_0000115 "An element formed from the fusion of metatarsal 3 and metatarsal 4." ; obo:UBPROP_0000008 "In many artiodactyls, the 3rd & 4th metapodials are fused, creating a main metapodial." ; oboInOwl:hasExactSynonym "fused metatarsal 3/4", "os metatarsale III et IV (Ru)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metatarsal 3+4" ; oboInOwl:id "UBERON:0013588" ; a owl:Class ; rdfs:label "fused metatarsal bones 3 and 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001448 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003652 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003653 ] ) ] . obo:UBERON_0013616 obo:IAO_0000116 "TODO - logical definition" ; oboInOwl:hasDbXref "FMA:84206", "SCTID:368703003" ; oboInOwl:hasExactSynonym "deciduous molar tooth", "primary molar tooth", "temporary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013616" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "primary molar tooth" ; owl:equivalentClass _:genid153304 . obo:UBERON_0013617 obo:IAO_0000115 "A primary molar tooth that is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:84210", "SCTID:422318005" ; oboInOwl:hasExactSynonym "primary upper molar tooth", "upper deciduous molar", "upper deciduous molar tooth", "upper primary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013617" ; a owl:Class ; rdfs:label "upper primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013616 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0013618 oboInOwl:hasDbXref "FMA:84207", "SCTID:421593002" ; oboInOwl:hasExactSynonym "permanent molar tooth", "secondary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013618" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003655 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0013619 obo:IAO_0000115 "A secondary molar tooth that is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:55720" ; oboInOwl:hasExactSynonym "maxillary secondary molar tooth", "upper permanent molar tooth", "upper secondary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013619" ; a owl:Class ; rdfs:label "upper secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013618 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0013620 obo:IAO_0000115 "A primary molar tooth that is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:84213", "SCTID:421482001" ; oboInOwl:hasExactSynonym "lower deciduous molar tooth", "primary lower molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013620" ; a owl:Class ; rdfs:label "lower primary molar tooth" ; owl:equivalentClass _:genid153332 . obo:UBERON_0013621 obo:IAO_0000115 "A secondary molar tooth that is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:55721" ; oboInOwl:hasExactSynonym "lower permanent molar", "lower permanent molar tooth", "mandibular secondary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013621" ; a owl:Class ; rdfs:label "lower secondary molar tooth" ; owl:equivalentClass _:genid153338 . obo:UBERON_0013630 obo:IAO_0000115 "Short bones are designated as those bones that are as wide as they are long. Their primary function is to provide support and stability with little to no movement. They are one of five types of bones: long, short, flat, irregular and sesamoid. Examples of these bones include the tarsals in the foot and the carpals in the hand." ; obo:IAO_0000116 "TODO - make subclass links" ; oboInOwl:hasDbXref "FMA:7475", "NCIT:C33545", "SCTID:332807009", "Wikipedia:Short_bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013630" ; a owl:Class ; rdfs:label "short bone" ; rdfs:subClassOf obo:UBERON_0001474 . obo:UBERON_0013631 obo:IAO_0000115 "Ossicle that develops within bands of dense, regular connective tissue (e.g., tendons and ligaments). Sesamoids are generally located proximate to a bony prominence, over which the dense regular connective tissue wraps, and/or a joint or articulation." ; oboInOwl:hasDbXref "VSAO:0000137" ; oboInOwl:hasExactSynonym "sesamoid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013631" ; a owl:Class ; rdfs:comment "Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage." ; rdfs:label "sesamoid element" ; rdfs:subClassOf obo:UBERON_0010911, _:genid155534 . obo:UBERON_0013632 obo:IAO_0000115 "A sesamoid element that is composed primarily of cartilage tissue." ; oboInOwl:hasDbXref "FMA:55379" ; oboInOwl:hasExactSynonym "cartilago sesamoidea", "sesamoid cartilage of cricopharyngeal ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013632" ; a owl:Class ; rdfs:label "sesamoid cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013631 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0013636 obo:IAO_0000115 "An epithelium that is part of a intestinal villus." ; oboInOwl:hasDbXref "FMA:63587" ; oboInOwl:hasExactSynonym "intestinal villus epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "villous epithelium", "villus epithelium" ; oboInOwl:id "UBERON:0013636" ; a owl:Class ; rdfs:label "epithelium of intestinal villus" ; rdfs:subClassOf _:genid155549 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:UBERON_0013637 obo:IAO_0000115 "The prostate gland lobe that is located on the lateral side of the organ." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "EMAPA:29822", "FMA:19577", "MA:0003125", "NCIT:C13092" ; oboInOwl:hasExactSynonym "lateral lobe of prostate", "lateral lobe of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral prostate", "lateral ventral lobe of prostate gland" ; oboInOwl:id "UBERON:0013637" ; a owl:Class ; rdfs:label "prostate gland lateral lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001328 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0013646 obo:IAO_0000115 "The buccal nerve (also called the long buccal nerve) is a nerve in the face. It is a branch of the mandibular nerve (which is itself a branch of the trigeminal nerve) and transmits sensory information from skin over the buccal membrane (in general, the cheek) and from the second and third molar teeth." ; oboInOwl:hasDbXref "BAMS:bucn", "FMA:53066", "SCTID:280253000", "Wikipedia:Buccal_nerve" ; oboInOwl:hasExactSynonym "buccinator nerve", "long buccal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "buccinator branch", "long buccal nerve" ; oboInOwl:id "UBERON:0013646" ; a owl:Class ; rdfs:label "buccal nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001567 ], _:genid155562 . obo:UBERON_0013647 obo:IAO_0000115 "A nerve that innervates the lateral pterygoid muscle." ; obo:UBPROP_0000001 "The nerve to the Pterygoideus externus frequently arises in conjunction with the buccinator nerve, but it may be given off separately from the anterior division of the mandibular nerve. It enters the deep surface of the muscle." ; oboInOwl:hasDbXref "FMA:53107", "SCTID:48852002", "Wikipedia:Lateral_pterygoid_nerve" ; oboInOwl:hasExactSynonym "branch of buccal nerve to lateral pterygoid", "nerve to lateral pterygoid", "nervus pterygoideus lateralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external pterygoid nerve" ; oboInOwl:id "UBERON:0013647" ; a owl:Class ; rdfs:label "lateral pterygoid nerve" ; rdfs:subClassOf _:genid155573 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006719 ] ) ] . obo:UBERON_0013648 obo:IAO_0000115 "The masseteric artery is small and passes laterally through the mandibular notch to the deep surface of the masseter muscle, which it supplies. It anastomoses with the masseteric branches of the external maxillary artery and with the transverse facial artery." ; oboInOwl:hasDbXref "FMA:49739", "NCIT:C53052", "SCTID:147864007", "UMLS:C0226149", "Wikipedia:Masseteric_artery" ; oboInOwl:hasExactSynonym "arteria masseterica" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013648" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "masseteric artery" ; rdfs:subClassOf _:genid155585 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001597 ] ) ] . obo:UBERON_0013649 obo:IAO_0000115 "A tarsal bone that is formed from the fusion of the 1st and 2nd tarsal bones." ; oboInOwl:hasExactSynonym "fused tarsals 1 and 2", "os cuneiforme mediointermedium", "os tarsale I et II" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tarsals 1+2" ; oboInOwl:id "UBERON:0013649" ; a owl:Class ; rdfs:label "fused tarsal bones 1 and 2" ; rdfs:subClassOf obo:UBERON_0010721 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001453 ] ) ] . obo:UBERON_0013678 obo:IAO_0000115 "An anatomical line of the face that connects the two inner (medial) canthi of the eye. The length of this line is known as the inter canthal distance." ; oboInOwl:hasBroadSynonym "inter-canthal line", "intercanthal line" ; oboInOwl:hasDbXref "FMA:284806" ; oboInOwl:hasExactSynonym "inter inner canthal line", "inter medial canthal line" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bicanthal plane" ; oboInOwl:id "UBERON:0013678" ; a owl:Class ; rdfs:label "anatomical line between inner canthi" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid153409 ] . obo:UBERON_0013679 obo:IAO_0000115 "An inner canthus that is part of a right eye." ; oboInOwl:hasDbXref "FMA:59319" ; oboInOwl:hasExactSynonym "right inner canthus", "right medial canthus", "right medial palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial angle of right eye", "medial canthus of right eye" ; oboInOwl:id "UBERON:0013679" ; a owl:Class ; rdfs:label "inner canthus of right eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005611 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004549 ] ) ] . obo:UBERON_0013680 obo:IAO_0000115 "An inner canthus that is part of a left eye." ; oboInOwl:hasDbXref "FMA:59320" ; oboInOwl:hasExactSynonym "left inner canthus", "left medial canthus", "left medial palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial angle of left eye", "medial canthus of left eye" ; oboInOwl:id "UBERON:0013680" ; a owl:Class ; rdfs:label "inner canthus of left eye" ; owl:equivalentClass _:genid153425 . obo:UBERON_0013683 obo:IAO_0000115 "A dorsal thalamus that is in_the_left_side_of a diencephalon." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "left thalamus" ; oboInOwl:hasDbXref "FMA:258716" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013683" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left dorsal thalamus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004703 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0013684 obo:IAO_0000115 "A dorsal thalamus that is in_the_right_side_of a diencephalon." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasBroadSynonym "right thalamus" ; oboInOwl:hasDbXref "FMA:258714" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013684" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right dorsal thalamus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004703 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0013685 obo:IAO_0000115 "Anatomical space that is an opening in a bone of the skull." ; oboInOwl:hasDbXref "FMA:53165", "SCTID:276742007", "Wikipedia:Foramina_of_the_skull" ; oboInOwl:hasExactSynonym "foramen of skull" ; oboInOwl:hasNarrowSynonym "cranial conduit", "cranial foramen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramina of the skull" ; oboInOwl:id "UBERON:0013685" ; a owl:Class ; rdfs:label "foramen of skull" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005744 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:UBERON_0013686 obo:IAO_0000115 "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FMA:9338" ; oboInOwl:hasNarrowSynonym "foramen space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013686" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical conduit space" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0004111 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0000464 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] . obo:UBERON_0013687 obo:IAO_0000115 "Periosteum that is part of a skull." ; oboInOwl:hasDbXref "FMA:76623" ; oboInOwl:hasExactSynonym "periosteum externum cranii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013687" ; a owl:Class ; rdfs:label "pericranium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002515 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:UBERON_0013688 obo:IAO_0000115 "A germinal center that is part of a tonsil." ; obo:IAO_0000116 "consider adding related terms, e.g. secondary lymphoid tissue of tonsil" ; obo:UBPROP_0000001 "The germinal center or reaction center is the activated center of a lymphoid follicle in secondary lymphoid tissue where B-lymphocytes are stimulated by antigens and helper T cells (T-lymphocytes, helper-inducer) are stimulated to generate memory cells. Here, the germinal center of a tonsil[TS-1288]." ; oboInOwl:hasDbXref "CALOHA:TS-1288" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tonsil reaction center" ; oboInOwl:id "UBERON:0013688" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tonsil germinal center" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:UBERON_0013691 obo:IAO_0000115 "A zone of soft tissue located on the posterior of the lateral side of the pelvic region corresponding to the gluteal muscles." ; obo:UBPROP_0000007 "gluteal" ; obo:UBPROP_0000202 obo:FMA_76446 ; oboInOwl:hasDbXref "CALOHA:TS-2224", "EFO:0003070", "FMA:25245", "MESH:D002081", "NCIT:C89806", "SCTID:362677002", "UMLS:C0006497", "Wikipedia:Buttocks" ; oboInOwl:hasExactSynonym "clunis", "gluteal part of pelvic girdle", "gluteal region", "regio glutealis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "buttocks" ; oboInOwl:id "UBERON:0013691" ; oboInOwl:inSubset core:efo_slim, core:pheno_slim ; a owl:Class ; rdfs:label "buttock" ; rdfs:subClassOf obo:UBERON_0034929, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002000 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001271 ], _:genid155661 . obo:UBERON_0013694 obo:IAO_0000115 "Vascular endothelium found in blood vessels of the blood-brain-barrier." ; oboInOwl:hasDbXref "BTO:0001852", "BTO:0003248", "CALOHA:TS-0092" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebromicrovascular endothelium" ; oboInOwl:id "UBERON:0013694" ; a owl:Class ; rdfs:label "brain endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0013695 obo:IAO_0000115 "Vascular endothelium found in colon blood vessels." ; oboInOwl:hasDbXref "CALOHA:TS-0162" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "colon endothelial cell", "colon endothelial cells", "colonic endothelial cell", "colonic endothelium", "colorectal endothelial cell", "colorectal endothelium" ; oboInOwl:id "UBERON:0013695" ; a owl:Class ; rdfs:label "colon endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0013696 obo:IAO_0000115 "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." ; oboInOwl:hasDbXref "CALOHA:TS-2070" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium of tonsil", "tonsil epithelial cell" ; oboInOwl:id "UBERON:0013696" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tonsil epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] . obo:UBERON_0013697 obo:IAO_0000115 "Epithelium lining the exocrine pancreas." ; oboInOwl:hasDbXref "CALOHA:TS-2108" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epithelium of exocrine pancreas", "exocrine pancreas epithelial cell" ; oboInOwl:id "UBERON:0013697" ; a owl:Class ; rdfs:label "exocrine pancreas epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:UBERON_0013698 obo:IAO_0000115 "A hair in the frontal genital area of adolescent and adult humans, located on and around the sex organs, the crotch, and sometimes at the top of the inside of the thighs, in the pubic region around the pubis bone." ; oboInOwl:hasDbXref "FMA:54319", "NCIT:C33424", "UMLS:C1305636", "Wikipedia:Pubic_hair" ; oboInOwl:hasExactSynonym "pubic hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013698" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "strand of pubic hair" ; rdfs:subClassOf obo:UBERON_0001037 . obo:UBERON_0013699 obo:IAO_0000115 "A strand of hair that is part of a axilla." ; obo:UBPROP_0000202 obo:FMA_70756 ; oboInOwl:hasDbXref "FMA:54253", "SCTID:280911007" ; oboInOwl:hasExactSynonym "axilla hair", "axillary hair", "hair of axilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013699" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "strand of axillary hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] . obo:UBERON_0013700 obo:IAO_0000115 "Musculature of the head and neck, spine, and ribs." ; oboInOwl:hasDbXref "EHDAA2:0000159", "EMAPA:18166" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013700" ; a owl:Class ; rdfs:label "axial musculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013701 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0005944 ] ) ] . obo:UBERON_0013701 obo:IAO_0000115 "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013701" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "main body axis" ; rdfs:subClassOf obo:UBERON_0000475 . obo:UBERON_0013702 obo:IAO_0000115 "The region of the organism associated with the visceral organs." ; obo:UBPROP_0000001 "Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]." ; oboInOwl:hasDbXref "AEO:0000103", "BTO:0001489", "EMAPA:36031", "FMA:231424" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "body", "whole body" ; oboInOwl:id "UBERON:0013702" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "body proper" ; rdfs:subClassOf obo:UBERON_0000475, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013701 ] . obo:UBERON_0013703 obo:IAO_0000115 "Anatomical projection that is part of the integumentl system." ; oboInOwl:hasNarrowSynonym "skin projection" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013703" ; a owl:Class ; rdfs:label "integumentary projection" ; rdfs:subClassOf obo:UBERON_0006003 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] ) ] . obo:UBERON_0013704 obo:IAO_0000115 "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." ; oboInOwl:hasDbXref "FMA:293127", "NCIT:C34230", "UMLS:C1518428" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "chordal canal" ; oboInOwl:id "UBERON:0013704" ; a owl:Class ; rdfs:label "notochordal canal" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006268 ] ) ] . obo:UBERON_0013705 obo:IAO_0000115 "The deep layer (fascia of Scarpa) is a layer of the anterior abdominal wall." ; oboInOwl:hasDbXref "FMA:19923", "Wikipedia:Fascia_of_Scarpa" ; oboInOwl:hasExactSynonym "Colles' fascia", "Scarpa's fascia", "deep layer of superficial fascia of abdomen", "membranous layer of subcutaneous tissue of abdomen", "membranous layer of superficial fascia of abdomen", "stratum membranosum telae subcutaneae abdominis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "Colles fascia", "Scarpa's fascia", "fascia of Scarpa" ; oboInOwl:id "UBERON:0013705" ; a owl:Class ; rdfs:label "fascia of Scarpa" ; rdfs:subClassOf obo:UBERON_0003916, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] . obo:UBERON_0013718 obo:IAO_0000115 "The dartos fascia is a fat-free layer of smooth muscular fiber outside the external spermatic fascia but below the skin. It is a continuation of Scarpa's Fascia which is a membranous layer of the subcutaneous tissue in the abdominal wall." ; obo:UBPROP_0000007 "dartoic", "dartoid" ; oboInOwl:hasDbXref "FMA:18088", "Wikipedia:Dartos" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dartos muscle", "dartos tunic", "tunica dartos" ; oboInOwl:id "UBERON:0013718" ; a owl:Class ; rdfs:label "dartos muscle" ; rdfs:subClassOf obo:UBERON_0008982, [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0013705 ] . obo:UBERON_0013719 obo:IAO_0000115 "A dartos muscle that is part of a male reproductive system." ; obo:UBPROP_0000009 "The tunica dartos acts to regulate the temperature of the testicles, which promotes spermatogenesis. It does this by expanding or contracting to wrinkle the scrotal skin. The wrinkled (rugose) appearance of the scrotum is due to this layer of fascia" ; obo:UBPROP_0000012 "the FMA class appears to belong here due to its synonyms." ; oboInOwl:hasDbXref "FMA:27647", "SCTID:279582001" ; oboInOwl:hasExactSynonym "dartos layer of scrotum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dartos tunic" ; oboInOwl:id "UBERON:0013719" ; a owl:Class ; rdfs:label "dartos muscle of scrotum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0001659 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013718 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0013720 obo:IAO_0000115 "A dartos muscle that is part of a female reproductive system." ; oboInOwl:hasExactSynonym "dartos layer of labia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dartos muliebris" ; oboInOwl:id "UBERON:0013720" ; a owl:Class ; rdfs:label "dartos muscle of labia majora" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004085 ] ; owl:equivalentClass _:genid153573 . obo:UBERON_0013721 obo:IAO_0000115 "The entrance to the inguinal canal." ; oboInOwl:hasDbXref "FMA:19927", "NCIT:C32832", "SCTID:278831000", "Wikipedia:Deep_inguinal_ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal inguinal ring", "annulus inguinalis profundus", "internal abdominal ring", "internal inguinal ring", "internal ring" ; oboInOwl:id "UBERON:0013721" ; a owl:Class ; rdfs:label "deep inguinal ring" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006674 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001101 ; owl:someValuesFrom obo:UBERON_0006204 ] ) ] . obo:UBERON_0013727 obo:IAO_0000115 "Fluid contained within the notochordal canal." ; oboInOwl:hasExactSynonym "notochord fluid", "portion of notochordal fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013727" ; a owl:Class ; rdfs:comment "Distinct feature of coelocanths" ; rdfs:label "notochordal fluid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006314 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036242 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0013704 ] ) ] . obo:UBERON_0013748 obo:IAO_0000115 "A metaphysis that is part of a ulna." ; oboInOwl:hasDbXref "FMA:33767" ; oboInOwl:hasExactSynonym "metaphysis of ulna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013748" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ulnar metaphysis" ; rdfs:subClassOf _:genid155793 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001424 ] ) ] . obo:UBERON_0013749 obo:IAO_0000115 "A metaphysis that is part of a metaphysis." ; oboInOwl:hasDbXref "FMA:32830" ; oboInOwl:hasExactSynonym "diaphyseal end of humerus", "humeral metaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013749" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metaphysis of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_0013750 obo:IAO_0000115 "A metaphysis that is part of a tibia." ; oboInOwl:hasDbXref "EMAPA:37772", "FMA:33135", "MA:0003106" ; oboInOwl:hasExactSynonym "tibial metaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013750" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metaphysis of tibia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ] . obo:UBERON_0013751 obo:IAO_0000115 "A metaphysis that is part of a radius bone." ; oboInOwl:hasDbXref "FMA:33789" ; oboInOwl:hasExactSynonym "radial metaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013751" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "metaphysis of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0013752 obo:IAO_0000115 "A diaphysis that is part of a metacarpal bone." ; oboInOwl:hasDbXref "FMA:33804" ; oboInOwl:hasExactSynonym "body of metacarpal", "corpus ossis metacarpi", "metacarpal bone diaphysis", "shaft of metacarpal", "shaft of metacarpal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013752" ; a owl:Class ; rdfs:label "diaphysis of metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] . obo:UBERON_0013753 obo:IAO_0000115 "A distal epiphysis that is part of a metacarpal bone." ; oboInOwl:hasDbXref "FMA:33798" ; oboInOwl:hasExactSynonym "caput ossis metacarpi", "distal end of metacarpal bone", "head of metacarpal bone", "lower end of metacarpal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013753" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal epiphysis of metacarpal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002374 ] ) ] . obo:UBERON_0013754 obo:IAO_0000115 "An organ component layer that is part of a integumental system." ; oboInOwl:hasDbXref "SCTID:314820002" ; oboInOwl:hasNarrowSynonym "layer of skin", "skin layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013754" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "integumentary system layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] ) ] . obo:UBERON_0013755 obo:IAO_0000115 "A blood that is part of a artery." ; oboInOwl:hasDbXref "FMA:83066" ; oboInOwl:hasExactSynonym "arterial blood", "blood in artery", "portion of arterial blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013755" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "arterial blood" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001637 ] ) ] . obo:UBERON_0013756 obo:IAO_0000115 "A blood that is part of a vein." ; oboInOwl:hasDbXref "FMA:83067" ; oboInOwl:hasExactSynonym "blood in vein", "portion of venous blood", "venous blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013756" ; a owl:Class ; rdfs:label "venous blood" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001638 ] ) ] . obo:UBERON_0013757 obo:IAO_0000115 "A blood that is part of a capillary." ; oboInOwl:hasDbXref "FMA:263901", "NCIT:C32212" ; oboInOwl:hasExactSynonym "blood in capillary", "portion of blood in capillary", "portion of capillary blood" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013757" ; a owl:Class ; rdfs:label "capillary blood" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001982 ] ) ] . obo:UBERON_0013758 obo:IAO_0000115 "One of two openings in the uterine cervix." ; oboInOwl:hasDbXref "FMA:20422" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervical opening", "uterine cervix opening" ; oboInOwl:id "UBERON:0013758" ; a owl:Class ; rdfs:label "cervical os" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0013760 obo:IAO_0000115 "Opening of uterine cervix into the vagina." ; obo:UBPROP_0000001 "The external orifice of the uterus (or ostium of uterus, or external os) is a small, depressed, somewhat circular aperture on the rounded extremity of the vaginal portion of the cervix. Through this aperture, the cervical cavity communicates with that of the vagina. The external orifice is bounded by two lips, an anterior and a posterior. The anterior is shorter and thicker, though it projects lower than the posterior because of the slope of the cervix. Normally, both lips are in contact with the posterior vaginal wall. Prior to pregnancy, the external orifice has a rounded shape when viewed through the vaginal canal (as through a speculum). Following parturition, the orifice takes on an appearance more like a transverse slit or is 'H-shaped'[Wikipedia:External_orifice_of_the_uterus]." ; oboInOwl:hasDbXref "FMA:76836", "NCIT:C32491", "SCTID:362255005", "UMLS:C1512165", "Wikipedia:External_orifice_of_the_uterus" ; oboInOwl:hasExactSynonym "external os of uterus", "ostium uteri" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external os", "ostium of uterus" ; oboInOwl:id "UBERON:0013760" ; a owl:Class ; rdfs:label "external cervical os" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012249 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000002 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000996 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013758 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0013761 obo:IAO_0000115 "The cavity formed by the walls of the cervix." ; oboInOwl:hasDbXref "BTO:0002249", "FMA:17746", "Wikipedia:Canal_of_the_cervix" ; oboInOwl:hasExactSynonym "lumen of cervix of uterus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "canal of the cervix", "cavity of cervix", "cervical canal", "cervical canal of uterus", "endocervical", "endocervical canal", "endocervix" ; oboInOwl:id "UBERON:0013761" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0013765 obo:IAO_0000115 "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." ; oboInOwl:hasDbXref "EMAPA:37843", "SCTID:272627002" ; oboInOwl:hasExactSynonym "digestive organ", "digestive system organ" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013765" ; oboInOwl:inSubset core:grouping_class, core:pheno_slim ; a owl:Class ; rdfs:label "digestive system element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ] ) ] . obo:UBERON_0013766 obo:IAO_0000115 "A fold of skin of the upper eyelid that partially covers the inner corner of the eye." ; oboInOwl:hasDbXref "FMA:59370", "SCTID:74824007", "Wikipedia:Epicanthic_fold" ; oboInOwl:hasExactSynonym "epicanthic fold", "epicanthus", "eye fold", "medial canthic fold", "palpebronasal fold", "plica palpebronasalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013766" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epicanthal fold" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005611 ] . obo:UBERON_0013767 obo:IAO_0000115 "A plate of bone from the maxilla that that projects upward, medialward, and backward, by the side of the nose, forming part of its lateral boundary[WP,modified]." ; oboInOwl:hasDbXref "FMA:52894", "SCTID:368869008", "Wikipedia:Frontal_process_of_maxilla" ; oboInOwl:hasExactSynonym "processus frontalis (maxilla)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "frontal appendage of maxilla", "frontal process of the maxilla", "nasal process of maxilla", "processus frontalis maxillae" ; oboInOwl:id "UBERON:0013767" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "frontal process of maxilla" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002397 ] . obo:UBERON_0013768 obo:IAO_0000115 "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." ; oboInOwl:hasBroadSynonym "great vessel" ; oboInOwl:hasDbXref "EMAPA:36460", "SCTID:304066000", "Wikipedia:Great_vessels" ; oboInOwl:hasExactSynonym "great vessel of thorax" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013768" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:comment "Groupings may vary - typically pulmonary vessels and aorta and vena cavae" ; rdfs:label "great vessel of heart" ; rdfs:subClassOf obo:UBERON_0001981 . obo:UBERON_0013769 obo:IAO_0000115 "An organ cavity that is part of a uterus." ; oboInOwl:hasDbXref "EMAPA:36273", "FMA:17745", "Wikipedia:Uterine_cavity" ; oboInOwl:hasExactSynonym "cavity of uterus", "uterine cavity", "uterine space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013769" ; a owl:Class ; rdfs:label "uterine lumen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002558 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ] . obo:UBERON_0013771 obo:IAO_0000115 "Line across midline connecting a left and right nipples." ; obo:UBPROP_0000008 "In mammals with multiple pairs of nipples, this line is only applicable for laterally homologous nipples" ; oboInOwl:hasExactSynonym "intermammary line" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013771" ; a owl:Class ; rdfs:label "line connecting laterally paired nipples" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001854 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013772 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013773 ] ) ] . obo:UBERON_0013772 obo:IAO_0000115 "A nipple that is in_the_left_side_of a body proper." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:223695" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013772" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left nipple" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002030 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0013702 ] ) ] . obo:UBERON_0013773 obo:IAO_0000115 "A nipple that is in_the_right_side_of a body proper." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:223693" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013773" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right nipple" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002030 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0013702 ] ) ] . obo:UBERON_0013774 obo:IAO_0000115 "A diaphysis that is part of a metatarsal bone." ; oboInOwl:hasDbXref "FMA:33826" ; oboInOwl:hasExactSynonym "diaphysis of metatarsal", "metatarsal bone diaphysis", "metatarsal diaphysis", "shaft of metatarsal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013774" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "diaphysis of metatarsal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001448 ] ) ] . obo:UBERON_0013776 obo:IAO_0000115 "A zone of skin that is part of a palmar/plantar part of autopod." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013776" ; a owl:Class ; rdfs:label "skin of palmar/plantar part of autopod" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008837 ] ) ] . obo:UBERON_0013777 obo:IAO_0000115 "A zone of skin that is part of a palmar part of manus." ; oboInOwl:hasDbXref "FMA:38301", "SCTID:181544004" ; oboInOwl:hasExactSynonym "palmar skin of hand", "skin of palmar area of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013777" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of palm of manus" ; rdfs:subClassOf _:genid155959 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008878 ] ) ] . obo:UBERON_0013778 obo:IAO_0000115 "A zone of skin that is part of a skin of pes." ; oboInOwl:hasDbXref "FMA:37849", "SCTID:181566006" ; oboInOwl:hasExactSynonym "plantar skin of foot", "skin of plantar part of foot", "skin of sole of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0013778" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of sole of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008338 ] ) ] . obo:UBERON_0014371 obo:IAO_0000115 "Embryonic structure that gives rise to the telencephalon." ; oboInOwl:hasDbXref "EHDAA2:0004424", "EMAPA:36024", "TAO:0000571", "ZFA:0000571" ; oboInOwl:hasExactSynonym "presumptive telencephalon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014371" ; a owl:Class ; rdfs:comment "paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP]" ; rdfs:label "future telencephalon" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006240 ], _:genid155976 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0014375 obo:IAO_0000115 "Any of the intrinsic muscles of the manus (hand)." ; obo:UBPROP_0000202 obo:FMA_42372 ; oboInOwl:hasDbXref "FMA:42380", "SCTID:244997002" ; oboInOwl:hasExactSynonym "intrinsic hand muscle", "intrinsic muscle of hand" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014375" ; a owl:Class ; rdfs:label "intrinsic muscle of manus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035112 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0014376 obo:IAO_0000115 "Any of the muscles of the thenar eminence, a raised fleshy area on the palm of the hand near the base of the thumb." ; obo:UBPROP_0000007 "thenar" ; oboInOwl:hasDbXref "FMA:64916", "SCTID:181640000", "Wikipedia:Thenar_eminence" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thenar compartment", "thenar eminence", "thenar muscle", "thenar muscles" ; oboInOwl:id "UBERON:0014376" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "thenar muscle" ; rdfs:subClassOf obo:UBERON_0014375 . obo:UBERON_0014378 obo:IAO_0000115 "Any of the intrinsic muscles of the pes (foot)." ; oboInOwl:hasDbXref "FMA:65020" ; oboInOwl:hasExactSynonym "intrinsic muscle of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014378" ; a owl:Class ; rdfs:label "intrinsic muscle of pes" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035112 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0014381 obo:IAO_0000115 "A patch of hair growing in the opposite direction of the rest of the hair." ; obo:UBPROP_0000202 obo:FMA_76564 ; oboInOwl:hasBroadSynonym "hair whorl", "whorl" ; oboInOwl:hasDbXref "Wikipedia:Hair_whorl" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014381" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Hair whorls occur in most hairy animals, on the body as well as on the head. Hair whorls, also known as crowns, swirls, trichoglyphs, or cowlicks, can be either clockwise or counterclockwise in direction of growth.[WP]" ; rdfs:label "whorl of hair" ; rdfs:subClassOf obo:UBERON_0010164 . obo:UBERON_0014382 obo:IAO_0000115 "A collection of hairs that is part of a craniocervical region." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014382" ; a owl:Class ; rdfs:label "collection of hairs on head or neck" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 ] ) ] . obo:UBERON_0014385 obo:IAO_0000115 "The entrance of the larynx is a triangular opening, narrow in front, wide behind, and sloping obliquely downward and backward. It is bounded, in front, by the epiglottis; behind, by the apices of the arytenoid cartilages, the corniculate cartilages, and the interarytenoid notch; and on either side, by a fold of mucous membrane, enclosing ligamentous and muscular fibers, stretched between the side of the epiglottis and the apex of the arytenoid cartilage; this is the aryepiglottic fold, on the posterior part of the margin of which the cuneiform cartilage forms a more or less distinct whitish prominence, the cuneiform tubercle. These folds form the upper borders of the quadrangular membrane." ; oboInOwl:hasDbXref "FMA:55448", "NCIT:C32147", "SCTID:245503009", "UMLS:C1510944", "Wikipedia:Aryepiglottic_fold" ; oboInOwl:hasExactSynonym "ary-epiglottic fold" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "aryepiglottic folds", "aryepiglottic sphincter", "aryepiglottis", "plica aryepiglottica" ; oboInOwl:id "UBERON:0014385" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "aryepiglottic fold" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 ], [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001737 ] . obo:UBERON_0014386 obo:IAO_0000115 "Either of the the top and bottom portions of the vertebral bodies that interface with the vertebral discs. It is composed of a layer of thickened cancellous bone." ; oboInOwl:hasBroadSynonym "endplate" ; oboInOwl:hasDbXref "BTO:0005552", "FMA:293500", "Wikipedia:Endplates" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014386" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "vertebral endplate" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001075 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002483 ] . obo:UBERON_0014387 obo:IAO_0000115 "Mesenchyme that develops_from the neural crest[Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32735", "FMA:293883" ; oboInOwl:hasExactSynonym "mesenchyme from neural crest", "neural crest derived mesenchyme", "neural crest mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014387" ; a owl:Class ; rdfs:label "mesenchyme derived from neural crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid153822 ] . obo:UBERON_0014388 obo:IAO_0000115 "The simple cuboidal epithelium lining the lumen of kidney collecting ducts." ; obo:UBPROP_0000008 "In mouse, the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" ; oboInOwl:hasDbXref "EMAPA:37885" ; oboInOwl:hasExactSynonym "collecting duct of renal tubule epithelium", "epithelium of collecting duct of renal tubule", "epithelium of renal collecting tubule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014388" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "kidney collecting duct epithelium" ; rdfs:subClassOf obo:UBERON_0000484, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001232 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001232 ] ) ] . obo:UBERON_0014389 obo:IAO_0000115 "A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae." ; oboInOwl:hasDbXref "FMA:54822" ; oboInOwl:hasExactSynonym "gustatory papilla", "taste papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gustatory papillae", "taste papillae" ; oboInOwl:id "UBERON:0014389" ; a owl:Class ; rdfs:label "gustatory papilla of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001726 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001727 ] ) ] . obo:UBERON_0014390 obo:IAO_0000115 "A muscular coat that is part of a ileum." ; oboInOwl:hasDbXref "BTO:0005574", "FMA:14958" ; oboInOwl:hasExactSynonym "muscularis externa of ileum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ileal smooth muscle", "muscularis propria of ileum", "smooth muscle of ileum" ; oboInOwl:id "UBERON:0014390" ; a owl:Class ; rdfs:label "muscle layer of ileum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0014391 obo:IAO_0000115 "A sweat gland that is part of the skin of the palmar part of the manus or plantar part of the pes." ; obo:UBPROP_0000008 "in mice these are the only sweat glands present" ; oboInOwl:hasNarrowSynonym "palm sweat gland", "palmar eccrine sweat gland", "sweat gland of palmar part of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palm/sole sweat gland", "palmar/plantar eccrine sweat gland", "sweat gland of palmar/plant part of autopod" ; oboInOwl:id "UBERON:0014391" ; a owl:Class ; rdfs:label "palmar/plantar sweat gland" ; rdfs:subClassOf obo:UBERON_0000423 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008837 ] ) ] . obo:UBERON_0014392 obo:IAO_0000115 "Sweat that is produced by the glands on the palmar and plantar surfaces." ; obo:UBPROP_0000009 "serves a purpose of increasing friction on the palms of hands or the pads of paws[WP]" ; oboInOwl:hasDbXref "FMA:63084" ; oboInOwl:hasExactSynonym "palm sweat", "palmar sweat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014392" ; a owl:Class ; rdfs:label "sweat of palm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001089 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0014391 ] ) ] . obo:UBERON_0014393 obo:IAO_0000115 "Sweat that is produced by the glands of the axilla." ; oboInOwl:hasDbXref "FMA:63085" ; oboInOwl:hasExactSynonym "axillary sweat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014393" ; a owl:Class ; rdfs:label "sweat of axilla" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001089 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0018232 ] ) ] . obo:UBERON_0014394 obo:IAO_0000115 "Encapsulated adipose tissue associated with the uterus." ; oboInOwl:hasDbXref "EMAPA:37979" ; oboInOwl:hasExactSynonym "uterine fat depot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "peri-uterine fat pad", "periuterine fat pad" ; oboInOwl:id "UBERON:0014394" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "uterine fat pad" ; owl:equivalentClass _:genid153868 . obo:UBERON_0014395 obo:IAO_0000115 "A proximal mesopodial endochondral element that is composed primarily of a bone tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014395" ; a owl:Class ; rdfs:label "proximal mesopodial bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0017751 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017750 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0014398 obo:IAO_0000115 "Muscle that is part of the respiratory system." ; obo:IAO_0000232 "this class may be merged with 'respiratory system muscle'; check intercostals" ; oboInOwl:hasDbXref "MESH:D012132" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014398" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "respiratory muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001134 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007585 ] ) ] . obo:UBERON_0014399 obo:IAO_0000115 "An anatomical space that is enclosed by a sinusoid." ; oboInOwl:hasDbXref "FMA:63133" ; oboInOwl:hasExactSynonym "lumen of sinusoid", "sinusoid lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014399" ; a owl:Class ; rdfs:label "sinusoidal space" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003909 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0003909 ] ) ] . obo:UBERON_0014400 obo:IAO_0000115 "A sinusoidal space that is part of a hepatic sinusoid." ; oboInOwl:hasDbXref "FMA:262090" ; oboInOwl:hasExactSynonym "lumen of hepatic sinusoid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014400" ; a owl:Class ; rdfs:label "hepatic sinusoidal space" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014399 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001281 ] ) ] . obo:UBERON_0014401 obo:IAO_0000115 "Any member of the network of tubes that return blood from the renal tissues to the systemic circulation." ; obo:UBPROP_0000012 "we follow MA and MP in distinguishing the venous blood vessel from the vein. The kidney cortex vein is not considered a renal vein, nor is the vasa recta" ; oboInOwl:hasDbXref "EMAPA:31450", "MA:0002591" ; oboInOwl:hasExactSynonym "kidney venous blood vessel", "venous blood vessel of kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "kidney venous system" ; oboInOwl:id "UBERON:0014401" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renal venous blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003920 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0014402 obo:IAO_0000115 "A part of the body present only in a specific gender." ; oboInOwl:hasDbXref "AEO:0000174", "WBbt:0005752" ; oboInOwl:hasExactSynonym "gender-specific", "gender-specific anatomical structure", "sex-specific" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014402" ; a owl:Class ; rdfs:label "sex-specific anatomical structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0007548 ] ) ] . obo:UBERON_0014403 obo:IAO_0000115 "A part of the body present only in males." ; oboInOwl:hasDbXref "AEO:0000175", "WBbt:0005757" ; oboInOwl:hasExactSynonym "male-specific structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "male-specific" ; oboInOwl:id "UBERON:0014403" ; a owl:Class ; rdfs:label "male anatomical structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014402 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] . obo:UBERON_0014404 obo:IAO_0000115 "A part of the body present only in females." ; oboInOwl:hasDbXref "AEO:0000176" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014404" ; a owl:Class ; rdfs:label "female anatomical structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014402 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ) ] . obo:UBERON_0014411 obo:IAO_0000115 "On the dorsal border of the wing of the ilium , at it's junction with the shaft is a cut away. This forms the Greater sciatic notch. The sciatic nerve runs over the notch in passage to the hindlimb." ; obo:UBPROP_0000001 "deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium[HP:0010456]." ; oboInOwl:hasDbXref "FMA:16902", "SCTID:292728005", "Wikipedia:Greater_sciatic_notch" ; oboInOwl:hasExactSynonym "greater sacrosciatic notch", "incisura ischiadica major" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014411" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "greater sciatic notch" ; rdfs:subClassOf obo:UBERON_0014430, [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0008529 ] . obo:UBERON_0014430 obo:IAO_0000115 "Either of two notches on the dorsal border of the hip bone on each side that when closed off by ligaments form the corresponding sciatic foramina." ; oboInOwl:hasDbXref "SCTID:360956007", "Wikipedia:Sciatic_notch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014430" ; a owl:Class ; rdfs:label "sciatic notch" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001274 ] . obo:UBERON_0014437 obo:IAO_0000115 "Is part of the pelvis on the edge of the wing of the ilium. Round in shape, dorsal to the pubis and ischium. Acts as structrure that muscles can attach too." ; oboInOwl:hasDbXref "EMAPA:37602", "FMA:16914", "MA:0003053", "NCIT:C103818", "SCTID:182034009" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014437" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "iliac crest" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001273 ] . obo:UBERON_0014438 obo:IAO_0000115 "The superior pubic ramus is a part of the pubic bone which forms a portion of the obturator foramen. It extends from the body to the median plane where it articulates with its fellow of the opposite side. It is conveniently described in two portions, viz. , a medial flattened part and a narrow lateral prismoid portion." ; oboInOwl:hasDbXref "FMA:16988", "SCTID:182037002", "Wikipedia:Superior_pubic_ramus" ; oboInOwl:hasExactSynonym "superior ramus of pubis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "superior rami of the pubes", "superior ramus of the pubis" ; oboInOwl:id "UBERON:0014438" ; a owl:Class ; rdfs:label "superior pubic ramus" ; rdfs:subClassOf obo:UBERON_0014444 . obo:UBERON_0014439 obo:IAO_0000115 "The inferior pubic ramus is thin and flattened. It passes lateralward and downward from the medial end of the superior ramus; it becomes narrower as it descends and joins with the inferior ramus of the ischium below the obturator foramen." ; oboInOwl:hasDbXref "FMA:16989", "SCTID:182038007", "Wikipedia:Inferior_pubic_ramus" ; oboInOwl:hasExactSynonym "inferior ramus of pubis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inferior rami of the pubes", "inferior ramus of the pubis" ; oboInOwl:id "UBERON:0014439" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "inferior pubic ramus" ; rdfs:subClassOf obo:UBERON_0014444 . obo:UBERON_0014444 oboInOwl:hasDbXref "SCTID:182026003" ; oboInOwl:hasExactSynonym "ramus of pubis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014444" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pubic ramus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001275 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0014438 obo:UBERON_0014439 ) ] . obo:UBERON_0014445 obo:IAO_0000115 "The acetabular fossa is the roughened depression in the centre of the acetabulum, surrounded by the lunate acetabular surface and the acetabular notch. The acetabular fossa provides an insertion point for the teres ligaments that secure the femoral head." ; oboInOwl:hasDbXref "FMA:17269", "SCTID:289666003", "Wikipedia:Acetabular_fossa" ; oboInOwl:hasExactSynonym "fossa acetabularis", "fossa acetabularis (acetabuli)", "fossa acetabuli" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014445" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "It is occupied by the ligament of head of femur[WP]" ; rdfs:label "acetabular fossa" ; rdfs:subClassOf obo:UBERON_0004704, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001272 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0014446 ] . obo:UBERON_0014446 obo:IAO_0000115 "The acetabulum presents below a deep notch, the acetabular notch, which is continuous with a circular non-articular depression, the acetabular fossa, at the bottom of the cavity: this depression is perforated by numerous apertures, and lodges a mass of fat. The notch is converted into a foramen by the transverse ligament; through the foramen nutrient vessels and nerves enter the joint; the margins of the notch serve for the attachment of the ligament of the head of the femur." ; oboInOwl:hasDbXref "FMA:16944", "SCTID:289767000", "Wikipedia:Acetabular_notch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014446" ; a owl:Class ; rdfs:label "acetabular notch" ; rdfs:subClassOf obo:UBERON_0004111, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001272 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0018411 ] . obo:UBERON_0014451 obo:IAO_0000115 "A taste bud that is located on the tongue, situated on a gustatory papilla." ; oboInOwl:hasExactSynonym "gustatory papilla taste bud", "gustatory papillae taste bud" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014451" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tongue taste bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0014452 obo:IAO_0000115 "A gustatory epithelium that is part of a tongue." ; oboInOwl:hasDbXref "BIRNLEX:4099", "UMLS:C1179150" ; oboInOwl:hasExactSynonym "lingual gustatory epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014452" ; a owl:Class ; rdfs:label "gustatory epithelium of tongue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002926 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0014453 obo:IAO_0000115 "A gustatory epithelium that is part of a roof of mouth." ; oboInOwl:hasExactSynonym "palatal gustatory epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014453" ; a owl:Class ; rdfs:label "gustatory epithelium of palate" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002424 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002926 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007375 ] ) ] . obo:UBERON_0014454 obo:IAO_0000115 "Subcutaneous adipose tissue that is located in the peritoneal cavity." ; obo:UBPROP_0000001 "Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively[BTO:0004041]." ; oboInOwl:hasDbXref "BTO:0004041", "CALOHA:TS-2405" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "abdominal fat", "intra-abdominal adipose tissue", "intra-abdominal fat", "organ fat", "visceral adipose tissue", "visceral fat" ; oboInOwl:id "UBERON:0014454" ; a owl:Class ; rdfs:label "visceral abdominal adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002075 ] ) ] . obo:UBERON_0014455 obo:IAO_0000115 "Subcutaneous adipose tissue that is located in the abdominal region." ; oboInOwl:hasDbXref "CALOHA:TS-2406" ; oboInOwl:hasExactSynonym "abdominal subcutaneous adipose tissue", "subcutaneous abdominal fat", "subcutaneous fat of abdominal region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014455" ; a owl:Class ; rdfs:label "subcutaneous abdominal adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0014463 obo:IAO_0000115 "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery." ; obo:UBPROP_0000001 "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery[http://medical-dictionary.thefreedictionary.com/cardiac+ganglion]." ; oboInOwl:hasDbXref "EMAPA:36644", "FMA:77582", "SCTID:57098005" ; oboInOwl:hasExactSynonym "Wrisberg ganglion", "cardiac ganglia set", "cardiac ganglion of Wrisberg", "ganglia cardiaca", "ganglion of Wrisberg" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac ganglia" ; oboInOwl:id "UBERON:0014463" ; a owl:Class ; rdfs:label "cardiac ganglion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000011 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001808 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002008 ] ) ] . obo:UBERON_0014464 obo:IAO_0000115 "Encapsulated adipose tissue associated with the kidney." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "perirenal fat pad" ; oboInOwl:id "UBERON:0014464" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0014466 oboInOwl:hasDbXref "FMA:75136" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014466" ; a owl:Class ; rdfs:label "subarachnoid fissure" ; rdfs:subClassOf obo:UBERON_0000464, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000315 ] . obo:UBERON_0014477 obo:IAO_0000115 "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." ; oboInOwl:hasDbXref "EHDAA2:0002013", "FMA:77169", "Wikipedia:Thoracic_skeleton" ; oboInOwl:hasExactSynonym "skeleton of thorax", "thoracic part of axial skeleton", "thoracic skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014477" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "thoracic skeleton" ; rdfs:subClassOf obo:UBERON_0010912, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ] . obo:UBERON_0014478 obo:IAO_0000115 "Subdivision of skeletal system that consists of all ribs and rib joints in an organism. In many vertebrates this consists of the combination of the rib cage and all rib joints, but some vertebrates have ribs outside the thoracic rib cage." ; oboInOwl:hasDbXref "FMA:265719", "TAO:0002100" ; oboInOwl:hasExactSynonym "rib series" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rib skeleton", "set of all ribs" ; oboInOwl:id "UBERON:0014478" ; a owl:Class ; rdfs:label "rib skeletal system" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011138 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003252 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0015019 ] . obo:UBERON_0014483 obo:IAO_0000115 "A distal phalanx that is part of a digit 1 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "digit 1 distal phalanx", "distal phalanx of digit I", "distal phalanx of first digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit I P3", "first distal phalanx" ; oboInOwl:id "UBERON:0014483" ; a owl:Class ; rdfs:label "distal phalanx of digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006048 ] ) ] . obo:UBERON_0014484 obo:IAO_0000115 "A distal phalanx that is part of a digit 2 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "2nd digit distal phalanx", "digit 2 distal phalanx", "distal phalanx of 2nd digit", "distal phalanx of digit II", "distal phalanx of index digit", "distal phalanx of second digit", "second digit distal phalanx", "second distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit II P3" ; oboInOwl:id "UBERON:0014484" ; a owl:Class ; rdfs:label "distal phalanx of digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006049 ] ) ] . obo:UBERON_0014485 obo:IAO_0000115 "A distal phalanx that is part of a digit 3. In odd-toes ungulates (Perissodactyla e.g. horses) this is called the coffin bone. In even-toed ungulates (Artiodactyla e.g cattle) this is associated with the medial claw." ; obo:UBPROP_0000008 "the bottommost bone in the equine leg and is encased by the hoof capsule. The distal phalanx articulates with both the middle phalanx and the distal sesamoid, forming the distal interphalangeal joint[Wikipedia:Coffin_bone]" ; oboInOwl:hasDbXref "SCTID:370666003", "SCTID:370671005", "SCTID:410030004", "Wikipedia:Coffin_bone" ; oboInOwl:hasExactSynonym "3rd digit distal phalanx", "digit 3 distal phalanx", "distal phalanx of 3rd digit", "distal phalanx of digit III", "distal phalanx of middle digit", "distal phalanx of third digit", "equine 3rd phalanx of digit 3", "equine distal phalanx", "third digit distal phalanx", "third distal phalanx" ; oboInOwl:hasNarrowSynonym "coffin bone", "medial claw of artiodactyl", "medial claw of ruminant hoof", "medial ungual phalanx of artiodactyl", "pedal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit III P3" ; oboInOwl:id "UBERON:0014485" ; a owl:Class ; rdfs:label "distal phalanx of digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006050 ] ) ] . obo:UBERON_0014486 obo:IAO_0000115 "A distal phalanx that is part of a digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:370667007", "SCTID:370670006" ; oboInOwl:hasExactSynonym "4th digit distal phalanx", "digit 4 distal phalanx", "distal phalanx of 4th digit", "distal phalanx of digit IV", "distal phalanx of fourth digit", "distal phalanx of ring digit", "fourth digit distal phalanx", "fourth distal phalanx" ; oboInOwl:hasNarrowSynonym "lateral claw of artiodactyl", "lateral claw of ruminant hoof", "lateral ungual phalanx of artiodactyl" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit IV P3" ; oboInOwl:id "UBERON:0014486" ; a owl:Class ; rdfs:label "distal phalanx of digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006051 ] ) ] . obo:UBERON_0014487 obo:IAO_0000115 "A distal phalanx that is part of a digit 5 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "5th digit distal phalanx", "digit 5 distal phalanx", "distal phalanx of 5th digit", "distal phalanx of digit V", "distal phalanx of fifth digit", "distal phalanx of little digit", "fifth digit distal phalanx", "fifth distal phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit V P3" ; oboInOwl:id "UBERON:0014487" ; a owl:Class ; rdfs:label "distal phalanx of digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004300 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006052 ] ) ] . obo:UBERON_0014488 obo:IAO_0000115 "A middle phalanx that is part of a digit 2 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "2nd digit intermediate phalanx", "2nd digit middle phalanx", "2nd digit of intermediate phalanx", "2nd digit of middle phalanx", "digit 2 intermediate phalanx", "digit 2 middle phalanx", "intermediate phalanx of 2nd digit", "intermediate phalanx of digit 2", "intermediate phalanx of second digit", "middle phalanx of 2nd digit", "middle phalanx of digit II", "middle phalanx of index digit", "middle phalanx of second digit", "second digit intermediate phalanx", "second digit middle phalanx", "second middle phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit II P2" ; oboInOwl:id "UBERON:0014488" ; a owl:Class ; rdfs:label "middle phalanx of digit 2" ; rdfs:subClassOf _:genid154083 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006049 ] ) ] . obo:UBERON_0014489 obo:IAO_0000115 "A middle phalanx that is part of a digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:370676000", "SCTID:370730008" ; oboInOwl:hasExactSynonym "3rd digit intermediate phalanx", "3rd digit middle phalanx", "3rd digit of intermediate phalanx", "3rd digit of middle phalanx", "digit 3 intermediate phalanx", "digit 3 middle phalanx", "intermediate phalanx of 3rd digit", "intermediate phalanx of digit 3", "intermediate phalanx of third digit", "middle phalanx of 3rd digit", "middle phalanx of digit III", "middle phalanx of middle digit", "middle phalanx of third digit", "third digit intermediate phalanx", "third digit middle phalanx", "third middle phalanx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit III P2" ; oboInOwl:id "UBERON:0014489" ; a owl:Class ; rdfs:label "middle phalanx of digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006050 ] ) ] . obo:UBERON_0014490 obo:IAO_0000115 "A middle phalanx that is part of a digit 4 [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:370675001" ; oboInOwl:hasExactSynonym "4th digit intermediate phalanx", "4th digit middle phalanx", "4th digit of intermediate phalanx", "4th digit of middle phalanx", "digit 4 intermediate phalanx", "digit 4 middle phalanx", "fourth digit intermediate phalanx", "fourth digit middle phalanx", "fourth middle phalanx", "intermediate phalanx of 4th digit", "intermediate phalanx of digit 4", "intermediate phalanx of fourth digit", "middle phalanx of 4th digit", "middle phalanx of digit IV", "middle phalanx of fourth digit", "middle phalanx of ring digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit IV P2" ; oboInOwl:id "UBERON:0014490" ; a owl:Class ; rdfs:label "middle phalanx of digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006051 ] ) ] . obo:UBERON_0014491 obo:IAO_0000115 "A middle phalanx that is part of a digit 5 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "5th digit intermediate phalanx", "5th digit middle phalanx", "5th digit of intermediate phalanx", "5th digit of middle phalanx", "digit 5 intermediate phalanx", "digit 5 middle phalanx", "fifth digit intermediate phalanx", "fifth digit middle phalanx", "fifth middle phalanx", "intermediate phalanx of 5th digit", "intermediate phalanx of digit 5", "intermediate phalanx of fifth digit", "middle phalanx of 5th digit", "middle phalanx of digit V", "middle phalanx of fifth digit", "middle phalanx of little digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit V P2" ; oboInOwl:id "UBERON:0014491" ; a owl:Class ; rdfs:label "middle phalanx of digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004301 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006052 ] ) ] . obo:UBERON_0014501 obo:IAO_0000115 "A proximal phalanx that is part of a autopod digit 1 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "digit I P1", "digit I-1", "first proximal phalanx of autopod", "proximal phalanx of digit I", "proximal phalanx of first digit of autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014501" ; a owl:Class ; rdfs:label "proximal phalanx of digit 1" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006048 ] ) ] . obo:UBERON_0014502 obo:IAO_0000115 "A proximal phalanx that is part of a autopod digit 2 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "2nd digit of autopod proximal phalanx", "2nd digit proximal phalanx", "autopod digit 2 proximal phalanx", "digit II-1", "digit IU P1", "proximal phalanx of 2nd digit", "proximal phalanx of 2nd digit of autopod", "proximal phalanx of digit II", "proximal phalanx of index digit", "proximal phalanx of second digit", "proximal phalanx of second digit of autopod", "second digit proximal phalanx", "second proximal phalanx of autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014502" ; a owl:Class ; rdfs:label "proximal phalanx of digit 2" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006049 ] ) ] . obo:UBERON_0014503 obo:IAO_0000115 "A proximal phalanx that is part of a autopod digit 3 [Automatically generated definition]." ; oboInOwl:hasDbXref "SCTID:370732000", "SCTID:370733005" ; oboInOwl:hasExactSynonym "3rd digit of autopod proximal phalanx", "3rd digit proximal phalanx", "autopod digit 3 proximal phalanx", "digit III P1", "digit III-1", "proximal phalanx of 3rd digit", "proximal phalanx of 3rd digit of autopod", "proximal phalanx of digit III", "proximal phalanx of middle digit", "proximal phalanx of third digit", "proximal phalanx of third digit of autopod", "third digit proximal phalanx", "third proximal phalanx of autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014503" ; a owl:Class ; rdfs:label "proximal phalanx of digit 3" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid154124 ] . obo:UBERON_0014504 obo:IAO_0000115 "A proximal phalanx that is part of a autopod digit 4 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "4th digit of autopod proximal phalanx", "4th digit proximal phalanx", "autopod digit 4 proximal phalanx", "digit IV P1", "digit IV-1", "fourth digit proximal phalanx", "fourth proximal phalanx of autopod", "proximal phalanx of 4th digit", "proximal phalanx of 4th digit of autopod", "proximal phalanx of digit IV", "proximal phalanx of fourth digit", "proximal phalanx of fourth digit of autopod", "proximal phalanx of ring digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014504" ; a owl:Class ; rdfs:label "proximal phalanx of digit 4" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006051 ] ) ] . obo:UBERON_0014505 obo:IAO_0000115 "A proximal phalanx that is part of a autopod digit 5 [Automatically generated definition]." ; oboInOwl:hasExactSynonym "5th digit of autopod proximal phalanx", "5th digit proximal phalanx", "autopod digit 5 proximal phalanx", "digit V P1", "digit V-1", "fifth digit proximal phalanx", "fifth proximal phalanx of autopod", "proximal phalanx of 5th digit", "proximal phalanx of 5th digit of autopod", "proximal phalanx of digit V", "proximal phalanx of fifth digit", "proximal phalanx of fifth digit of autopod", "proximal phalanx of little digit" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014505" ; a owl:Class ; rdfs:label "proximal phalanx of digit 5" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5106052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006052 ] ) ] . obo:UBERON_0014506 obo:IAO_0000115 "A distal inter-phalangeal joint that is part of the 3rd digit." ; obo:UBPROP_0000008 "In Equidae, this is known as the coffin joint, and is the articulation between the short pastern bone (P2) and the coffin bone (P3 / distal phalanx)" ; oboInOwl:hasDbXref "NCIT:C102292", "SCTID:196392002", "SCTID:370892008" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of digit III" ; oboInOwl:hasNarrowSynonym "coffin joint", "equine distal interphalangeal joint", "equine second interphalangeal joint of limb digit III" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal interphalangeal joint 3" ; oboInOwl:id "UBERON:0014506" ; a owl:Class ; rdfs:label "distal interphalangeal joint of digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006050 ] ) ] . obo:UBERON_0014507 obo:IAO_0000115 "A distal inter-phalangeal joint that is part of the 3rd pedal digit." ; oboInOwl:hasDbXref "FMA:35375", "SCTID:361880001" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of pedal digit III", "distal interphalangeal joint of third digit of foot", "distal interphalangeal joint of third toe" ; oboInOwl:hasNarrowSynonym "equine distal interphalangeal joint of hindlimb", "hindlimb coffin joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014507" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of pedal digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ] . obo:UBERON_0014508 obo:IAO_0000115 "A distal inter-phalangeal joint that is part of the 3rd manual digit." ; oboInOwl:hasDbXref "FMA:35337", "SCTID:361854002", "SCTID:370683007" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of manual digit III", "distal interphalangeal joint of middle finger" ; oboInOwl:hasNarrowSynonym "equine distal interphalangeal joint of forelimb", "equine second interphalangeal joint of forelimb digit III", "forelimb coffin joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014508" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ] . obo:UBERON_0014530 oboInOwl:hasBroadSynonym "lamina of neuraxis", "neuraxis lamina" ; oboInOwl:hasDbXref "FMA:83856" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014530" ; a owl:Class ; rdfs:label "white matter lamina of neuraxis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 ] ) ] . obo:UBERON_0014531 oboInOwl:hasBroadSynonym "diencephalon lamina", "lamina of diencephalon" ; oboInOwl:hasDbXref "FMA:62449" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014531" ; a owl:Class ; rdfs:label "white matter lamina of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0014532 oboInOwl:hasBroadSynonym "cerebral hemisphere lamina", "lamina of cerebral hemisphere" ; oboInOwl:hasDbXref "FMA:67951" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014532" ; a owl:Class ; rdfs:label "white matter lamina of cerebral hemisphere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] ) ] . obo:UBERON_0014538 obo:IAO_0000115 "A subdivision of the central canal of the spinal cord along its anterior-posterior axis. This is typically subdivided into cervical, thoracic, lumbar and sacral segments." ; oboInOwl:hasDbXref "BIRNLEX:717" ; oboInOwl:hasExactSynonym "regional part of spinal cord central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014538" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of spinal cord central canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002291 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0002291 ] ) ] . obo:UBERON_0014540 obo:IAO_0000115 "The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex." ; oboInOwl:hasDbXref "BIRNLEX:1105", "SCTID:362413004", "UMLS:C0228472", "neuronames:163" ; oboInOwl:hasExactSynonym "lamina alba of cerebellar cortex", "laminae albae of cerebellar cortex", "white lamina of cerebellum", "white laminae of cerebellum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "isthmus cinguli", "isthmus gyri cingulatus", "isthmus gyri cinguli", "isthmus of gyrus fornicatus", "isthmus of the cingulate gyrus", "isthmus-2", "laminae albae of cerebellar cortex" ; oboInOwl:id "UBERON:0014540" ; a owl:Class ; rdfs:label "white matter lamina of cerebellum" ; rdfs:subClassOf _:genid154205 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0014541 obo:IAO_0000115 "Part of spinal cord central canal contained in the thoracic spinal cord. It is continuous rostrally with the cervical spinal cord central canal and caudally with the lumbar spinal cord central canal." ; oboInOwl:hasDbXref "BIRNLEX:1395", "FMA:321588", "SCTID:71118002", "UMLS:C0228637" ; oboInOwl:hasExactSynonym "thoracic spinal cord central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014541" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracic division of spinal cord central canal" ; rdfs:subClassOf obo:UBERON_0014538 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014538 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0003038 ] ) ] . obo:UBERON_0014542 obo:IAO_0000115 "Part of central canal contained within the cervical spinal cord. It is continuous caudally with the thoracic spinal cord central canal and rostrally with the fourth ventricle of the brain via the obex." ; oboInOwl:hasDbXref "BIRNLEX:1511", "FMA:321590", "SCTID:280403009", "UMLS:C0228620" ; oboInOwl:hasExactSynonym "cervical spinal cord central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014542" ; a owl:Class ; rdfs:label "cervical division of cord spinal central canal" ; rdfs:subClassOf obo:UBERON_0014538 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014538 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0002726 ] ) ] . obo:UBERON_0014543 obo:IAO_0000115 "Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1604", "FMA:321589", "SCTID:280406001", "UMLS:C0228644" ; oboInOwl:hasExactSynonym "lumbar spinal cord central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014543" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar division of spinal cord central canal" ; rdfs:subClassOf obo:UBERON_0014538 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014538 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0002792 ] ) ] . obo:UBERON_0014547 obo:IAO_0000115 "Part of spinal cord central canal contained in the sacral spinal cord. It is continuous rostrally with the spinal cord central canal of the lumbar cord." ; oboInOwl:hasDbXref "FMA:321696", "NLXANAT:1010008", "SCTID:362450003" ; oboInOwl:hasExactSynonym "sacral spinal cord central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lumbosacral spinal cord central canal" ; oboInOwl:id "UBERON:0014547" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral division of spinal cord central canal" ; owl:equivalentClass _:genid154241 . obo:UBERON_0014610 obo:IAO_0000115 "A ventral horn of spinal cord that is part of a thoracic spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1410", "SCTID:367876000", "UMLS:C0228632", "UMLS:C1288552" ; oboInOwl:hasExactSynonym "thoracic spinal cord ventral horn" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thoracic spinal cord anterior horn" ; oboInOwl:id "UBERON:0014610" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracic spinal cord ventral horn" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003038 ] ) ] . obo:UBERON_0014613 obo:IAO_0000115 "A gray matter of spinal cord that is part of a cervical spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1521", "SCTID:362438009", "UMLS:C0228610" ; oboInOwl:hasExactSynonym "cervical spinal cord gray matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014613" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical spinal cord gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002726 ] ) ] . obo:UBERON_0014614 obo:IAO_0000115 "A white matter of spinal cord that is part of a cervical spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1531", "SCTID:174829001", "UMLS:C0228616" ; oboInOwl:hasExactSynonym "cervical spinal cord white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014614" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical spinal cord white matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002318 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002726 ] ) ] . obo:UBERON_0014621 obo:IAO_0000115 "A ventral horn of spinal cord that is part of a cervical spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:1680", "SCTID:174363005", "UMLS:C0228615", "UMLS:C1278740" ; oboInOwl:hasExactSynonym "cervical spinal cord ventral horn" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervical spinal cord anterior horn" ; oboInOwl:id "UBERON:0014621" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cervical spinal cord ventral horn" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002726 ] ) ] . obo:UBERON_0014636 obo:IAO_0000115 "A gray matter of spinal cord that is part of a thoracic spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:980", "SCTID:362441000", "UMLS:C0228627" ; oboInOwl:hasExactSynonym "thoracic spinal cord gray matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014636" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracic spinal cord gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003038 ] ) ] . obo:UBERON_0014637 obo:IAO_0000115 "A white matter of spinal cord that is part of a thoracic spinal cord." ; oboInOwl:hasDbXref "BIRNLEX:999", "SCTID:367881009", "UMLS:C0228633", "UMLS:C1288557" ; oboInOwl:hasExactSynonym "thoracic spinal cord white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014637" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "thoracic spinal cord white matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002318 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003038 ] ) ] . obo:UBERON_0014639 obo:IAO_0000115 "A sulcus of brain that is part of a frontal cortex." ; oboInOwl:hasDbXref "HBA:9354", "NCIT:C32639", "UMLS:C0459388" ; oboInOwl:hasExactSynonym "frontal lobe sulci", "frontal lobe sulcus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014639" ; a owl:Class ; rdfs:label "frontal sulcus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013118 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001870 ] ) ] . obo:UBERON_0014649 obo:IAO_0000115 "A white matter that is part of a medulla oblongata." ; oboInOwl:hasDbXref "BAMS:mw", "BIRNLEX:1024", "BIRNLEX:1414", "FMA:83944", "neuronames:778" ; oboInOwl:hasExactSynonym "substantia alba medullae oblongatae", "white matter of medulla", "white substance of medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medullary white matter" ; oboInOwl:id "UBERON:0014649" ; a owl:Class ; rdfs:label "white matter of medulla oblongata" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 ] ) ] . obo:UBERON_0014668 oboInOwl:hasDbXref "FMA:35334", "SCTID:361852003" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of index finger", "distal interphalangeal joint of manual digit II" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014668" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ] . obo:UBERON_0014670 oboInOwl:hasDbXref "FMA:35340", "SCTID:361856000" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of manual digit IV", "distal interphalangeal joint of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014670" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ] . obo:UBERON_0014671 oboInOwl:hasDbXref "FMA:35343", "SCTID:361858004" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of little finger", "distal interphalangeal joint of manural digit V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014671" ; a owl:Class ; rdfs:label "distal interphalangeal joint of manural digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0014672 oboInOwl:hasDbXref "FMA:35369", "SCTID:361878007" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of pedal digit II", "distal interphalangeal joint of second digit of foot", "distal interphalangeal joint of second toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014672" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of pedal digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ] . obo:UBERON_0014674 oboInOwl:hasDbXref "FMA:35387", "SCTID:361882009" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of fourth digit of foot", "distal interphalangeal joint of fourth toe", "distal interphalangeal joint of pedal digit IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014674" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of pedal digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ] . obo:UBERON_0014675 oboInOwl:hasDbXref "FMA:35393", "SCTID:361884005" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of fifth digit of foot", "distal interphalangeal joint of fifth toe", "distal interphalangeal joint of little toe", "distal interphalangeal joint of pedal digit V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014675" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "distal interphalangeal joint of pedal digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0014677 obo:IAO_0000115 "A distal interphalangeal joint that is part of a digit 2." ; obo:IAO_0000116 "check whether NCITA classes belong with hand or generic autopod" ; oboInOwl:hasDbXref "NCIT:C102291" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of digit II" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal interphalangeal joint 2" ; oboInOwl:id "UBERON:0014677" ; a owl:Class ; rdfs:label "distal interphalangeal joint of digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006049 ] ) ] . obo:UBERON_0014679 obo:IAO_0000115 "A distal interphalangeal joint that is part of a digit 4." ; oboInOwl:hasDbXref "NCIT:C102293" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of digit IV" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal interphalangeal joint 4" ; oboInOwl:id "UBERON:0014679" ; a owl:Class ; rdfs:label "distal interphalangeal joint of digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006051 ] ) ] . obo:UBERON_0014680 obo:IAO_0000115 "A distal interphalangeal joint that is part of a digit 5." ; oboInOwl:hasDbXref "NCIT:C102294" ; oboInOwl:hasExactSynonym "distal interphalangeal joint of digit V" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal interphalangeal joint 5" ; oboInOwl:id "UBERON:0014680" ; a owl:Class ; rdfs:label "distal interphalangeal joint of digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009768 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006052 ] ) ] . obo:UBERON_0014686 obo:IAO_0000115 "The angular vein formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the external nasal veins of the ala nasi, and communicates with the superior ophthalmic vein through the nasofrontal vein, thus establishing an important anastomosis between the anterior facial vein and the cavernous sinus." ; oboInOwl:hasDbXref "FMA:50893", "SCTID:151804007", "Wikipedia:Angular_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014686" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "angular vein" ; rdfs:subClassOf obo:UBERON_0001638, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001653 ] . obo:UBERON_0014687 obo:IAO_0000115 "Any of three grooves in the temporal lobe including the inferior, middle, and superior temporal sulci." ; oboInOwl:hasDbXref "HBA:9377", "NCIT:C33744", "UMLS:C0459389" ; oboInOwl:hasExactSynonym "temporal lobe sulci", "temporal lobe sulcus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014687" ; a owl:Class ; rdfs:label "temporal sulcus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013118 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001871 ] ) ] . obo:UBERON_0014693 oboInOwl:hasDbXref "FMA:49695", "SCTID:276151008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014693" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "inferior alveolar artery" ; rdfs:subClassOf obo:UBERON_0009654, _:genid156572 . obo:UBERON_0014695 obo:IAO_0000115 "The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint." ; oboInOwl:hasDbXref "FMA:49689", "SCTID:147157007", "Wikipedia:Deep_auricular_artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014695" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "deep auricular artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0010069 ], _:genid156579 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009655 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] ) ] . obo:UBERON_0014699 obo:IAO_0000115 "A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component." ; oboInOwl:hasDbXref "EHDAA2:0000479", "EMAPA:16374", "VHOG:0000282" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014699" ; a owl:Class ; rdfs:label "extraembryonic venous system" ; rdfs:subClassOf obo:UBERON_0014701 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004582 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:UBERON_0014701 obo:IAO_0000115 "A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component." ; oboInOwl:hasDbXref "EHDAA2:0000478", "EMAPA:16370", "VHOG:0001396" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014701" ; a owl:Class ; rdfs:label "extraembryonic vascular system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007798 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002331 ] ) ] . obo:UBERON_0014702 obo:IAO_0000115 "An epithelium that is part of a frontonasal prominence." ; oboInOwl:hasDbXref "EHDAA2:0004108", "EMAPA:32918" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014702" ; a owl:Class ; rdfs:label "frontonasal process epithelium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid156602 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004066 ] ) ] . obo:UBERON_0014703 obo:IAO_0000115 "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." ; oboInOwl:hasDbXref "EHDAA2:0004019", "EMAPA:25040" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014703" ; a owl:Class ; rdfs:label "anal membrane ectodermal component" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ) ] . obo:UBERON_0014704 obo:IAO_0000115 "An anatomical space that is enclosed by a pleuroperitoneal canal." ; oboInOwl:hasDbXref "EHDAA2:0004736", "EMAPA:25034" ; oboInOwl:hasExactSynonym "pleuro-peritoneal canal cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014704" ; a owl:Class ; rdfs:label "pleuroperitoneal canal lumen" ; rdfs:subClassOf _:genid156616 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0006279 ] ) ] . obo:UBERON_0014705 obo:IAO_0000115 "An epithelium that is part of a median lingual swelling." ; oboInOwl:hasDbXref "EHDAA2:0001085", "EMAPA:17188" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tuberculum impar epitheilium" ; oboInOwl:id "UBERON:0014705" ; a owl:Class ; rdfs:label "median lingual swelling epithelium" ; rdfs:subClassOf obo:UBERON_0000490, _:genid156625 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006756 ] ) ] . obo:UBERON_0014706 oboInOwl:hasDbXref "EHDAA2:0001147", "EMAPA:17646" ; oboInOwl:hasExactSynonym "metanephros primitive collecting ducts", "primitive collecting duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014706" ; a owl:Class ; rdfs:label "primitive renal collecting duct system" ; rdfs:subClassOf obo:UBERON_0007501, _:genid156630 . obo:UBERON_0014716 obo:IAO_0000115 "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." ; oboInOwl:hasDbXref "NCIT:C32828", "UMLS:C1512857", "Wikipedia:Interlobular_ducts" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014716" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "interlobular duct" ; rdfs:subClassOf obo:UBERON_0035050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0009911 ] ) ] . obo:UBERON_0014717 obo:IAO_0000115 "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." ; oboInOwl:hasDbXref "FMA:86278" ; oboInOwl:hasExactSynonym "acinus of mucuous gland", "mucus acinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014717" ; a owl:Class ; rdfs:label "mucous acinus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000319 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000414 ] ) ] . obo:UBERON_0014719 obo:IAO_0000115 "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." ; oboInOwl:hasDbXref "SCTID:205214009" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intralobular ductule" ; oboInOwl:id "UBERON:0014719" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "intralobular duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009911 ] ) ] . obo:UBERON_0014720 obo:IAO_0000115 "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intralobular ductule" ; oboInOwl:id "UBERON:0014720" ; a owl:Class ; rdfs:label "interlobar duct" ; rdfs:subClassOf obo:UBERON_0035050 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002384 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0009912 ] ) ] . obo:UBERON_0014762 obo:IAO_0000115 "An element formed from the fusion of metapodium bones 2, 3 and 4 (i.e. either metatarsals 2-4 or metacarpals 3-4)." ; oboInOwl:hasExactSynonym "fused central metapodials", "fused metapodials 2-4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "metapodial 2+3+4" ; oboInOwl:id "UBERON:0014762" ; a owl:Class ; rdfs:label "fused metapodial bones 2-4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0013582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0013583 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0013584 ] ) ] . obo:UBERON_0014763 obo:IAO_0000115 "An element formed from the fusion of metapodium bones 2, 3 and 4 in the pedal autopod." ; obo:UBPROP_0000008 "The cannon bone of the 3-toed jerboa (jaculus jaculus) is the postnatal fusion of the 3 central metatarsals, which are distinct ossified elements prenatally" ; oboInOwl:hasExactSynonym "fused central metatarsals", "fused metatarsals 2-4" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cannon bone", "metatarsal 2+3+4" ; oboInOwl:id "UBERON:0014763" ; a owl:Class ; rdfs:label "fused metatarsal bones 2-4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001448 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003651 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003652 ] _:genid154476 ) ] . obo:UBERON_0014768 obo:IAO_0000115 "A blood vessel that drains from from an upper eyelid." ; oboInOwl:hasDbXref "FMA:50907" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "venae palpebrales superiores" ; oboInOwl:id "UBERON:0014768" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "superior palpebral vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014769 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0014769 obo:IAO_0000115 "A blood vessel that drains from from an eyelid." ; oboInOwl:hasDbXref "FMA:51997", "SCTID:152208004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "palpebral veins", "venae palpebrales" ; oboInOwl:id "UBERON:0014769" ; a owl:Class ; rdfs:label "palpebral vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ], _:genid154495 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid154491 ] . obo:UBERON_0014770 obo:IAO_0000115 "An artery that supplies blood to an eyelid." ; obo:UBPROP_0000008 "In humans, the eyelids are supplied with blood by two arches on each upper and lower lid. The arches are formed by anastamoses of the lateral palpebral arteries and medial palpebral arteries, branching off from the lacrimal artery and ophthalmic artery, respectively. In amphibians, the eyelids may be supplied by branches of the lateral pretrosal arteries.[cjm]" ; oboInOwl:hasDbXref "SCTID:148571007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014770" ; a owl:Class ; rdfs:label "palpebral artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0014775 obo:IAO_0000115 "A neuromere that is part of the presumptive forebrain." ; oboInOwl:hasBroadSynonym "forebrain segment", "segment of forebrain" ; oboInOwl:hasDbXref "FMA:61996" ; oboInOwl:hasExactSynonym "forebrain neuromere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future prosencephalon" ; oboInOwl:id "UBERON:0014775" ; a owl:Class ; rdfs:label "prosomere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006240 ] ) ] . obo:UBERON_0014776 obo:IAO_0000115 "A neuromere that is part of the presumptive midbrain." ; oboInOwl:hasBroadSynonym "mesomere", "midbrain segment", "segment of midbrain" ; oboInOwl:hasDbXref "EHDAA2:0004352", "FMA:61997" ; oboInOwl:hasExactSynonym "mesomere of nervous system", "neuromere of mesomere group" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "future mesencephalon", "mesomere group" ; oboInOwl:id "UBERON:0014776" ; a owl:Class ; rdfs:label "midbrain neuromere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009616 ] ) ] . obo:UBERON_0014777 obo:IAO_0000115 "A neuromere that is part of the presumptive spinal cord." ; oboInOwl:hasDbXref "TAO:0001332", "ZFA:0001332" ; oboInOwl:hasExactSynonym "spinal cord metameric segment", "spinal neuromeres" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "spinal cord segment" ; oboInOwl:id "UBERON:0014777" ; a owl:Class ; rdfs:label "spinal neuromere" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004731 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006241 ] ) ] . obo:UBERON_0014780 obo:IAO_0000115 "Attached to the posterior border of the hard palate is a thin, firm fibrous lamella called the palatine aponeurosis, which supports the muscles and gives strength to the soft palate. It is thicker above than below, where it becomes very thin and difficult to define. Laterally it is continuous with the pharyngeal aponeurosis. It serves as the insertion for the Tensor veli palatini and Levator veli palatini, and the origin for the Musculus uvulae, Palatopharyngeus, and Palatoglossus. It provides support for the soft palate." ; oboInOwl:hasDbXref "FMA:49429", "Wikipedia:Palatine_aponeurosis" ; oboInOwl:hasExactSynonym "aponeurosis of tensor veli palatini", "aponeurosis palatina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014780" ; a owl:Class ; rdfs:label "palatine aponeurosis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006614 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ] ) ] . obo:UBERON_0014783 obo:IAO_0000115 "Any muscle organ that is part of a cloaca." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014783" ; a owl:Class ; rdfs:label "cloacal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) ] . obo:UBERON_0014790 obo:IAO_0000115 "The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ." ; oboInOwl:hasDbXref "EMAPA:18274", "FMA:54813", "SCTID:368727001", "Wikipedia:Lingual_septum" ; oboInOwl:hasExactSynonym "septum of tongue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "median fibrous septum", "septum of tongue", "tongue septum" ; oboInOwl:id "UBERON:0014790" ; a owl:Class ; rdfs:label "lingual septum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) ] . obo:UBERON_0014791 obo:IAO_0000115 "Any collection of muscles that is part of the forelimb stylopod region [Automatically generated definition]." ; oboInOwl:hasDbXref "FMA:50202" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "arm musculature", "muscle group of arm", "musculature of arm", "set of muscles of arm" ; oboInOwl:id "UBERON:0014791" ; a owl:Class ; rdfs:label "musculature of forelimb stylopod" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ) ] . obo:UBERON_0014792 obo:IAO_0000115 "Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "EMAPA:37864", "FMA:71297" ; oboInOwl:hasNarrowSynonym "muscles of lower limb", "musculature of lower limb", "musculi membri inferioris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014792" ; a owl:Class ; rdfs:label "musculature of pelvic complex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_0014793 obo:IAO_0000115 "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." ; obo:IAO_0000116 "currently defined by location rather than attachment" ; oboInOwl:hasDbXref "EMAPA:37861", "FMA:71296" ; oboInOwl:hasNarrowSynonym "muscles of upper limb", "musculature of upper limb", "musculi membri superioris", "set of muscles of upper limb", "upper limb musculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014793" ; a owl:Class ; rdfs:label "musculature of pectoral complex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_0014794 obo:IAO_0000115 "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014794" ; a owl:Class ; rdfs:label "pectoral appendage muscle" ; rdfs:subClassOf _:genid156778 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 ] ) ] . obo:UBERON_0014795 obo:IAO_0000115 "Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014795" ; a owl:Class ; rdfs:label "pelvic appendage muscle" ; rdfs:subClassOf _:genid156785 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004709 ] ) ] . obo:UBERON_0014796 obo:IAO_0000115 "A ring of fibrous tissue surrounding the optic nerve at its entrance at the apex of the orbit." ; oboInOwl:hasDbXref "FMA:49071", "Wikipedia:Annulus_of_Zinn" ; oboInOwl:hasExactSynonym "anulus of Zinn", "anulus tendineus communis", "common annular tendon", "common anular tendon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "annulus of Zinn", "annulus tendineus communis", "anulus tendineus", "anulus tendineus communis", "common tendinous ring", "ligament of Zinn", "tendon of Zinn" ; oboInOwl:id "UBERON:0014796" ; a owl:Class ; rdfs:label "common tendinous ring" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000941 ] . obo:UBERON_0014847 obo:IAO_0000115 "The Vastus intermedius (Cruraeus) arises from the front and lateral surfaces of the body of the femur in its upper two-thirds, sitting under Rectus Femoris and from the lower part of the lateral intermuscular septum. Its fibers end in a superficial aponeurosis, which forms the deep part of the Quadriceps femoris tendon. The Vastus medialis and Vastus intermedius appear to be inseparably united, but when the Rectus femoris has been reflected a narrow interval will be observed extending upward from the medial border of the patella between the two muscles, and the separation may be continued as far as the lower part of the intertrochanteric line, where, however, the two muscles are frequently continuous." ; obo:UBPROP_0000001 "Origin: anterior and lateral surfaces of femur; insertion: patella, common tendon of quadriceps femoris; innervation: femoral; action, extends leg[BTO:0002542]." ; oboInOwl:hasDbXref "BTO:0002542", "EMAPA:36243", "FMA:22433", "SCTID:181682001", "Wikipedia:Vastus_intermedius_muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cruraeus", "crureus", "intermediate great muscle", "intermediate vastus muscle", "musculus vastus intermedius", "vastus intermedialis", "vastus intermedius" ; oboInOwl:id "UBERON:0014847" ; a owl:Class ; rdfs:label "vastus intermedius" ; rdfs:subClassOf obo:UBERON_0001630, [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0014848 ], _:genid156802, _:genid156804 . obo:UBERON_0014848 oboInOwl:hasDbXref "FMA:46900", "SCTID:245175008" ; oboInOwl:hasExactSynonym "common tendon of quadriceps femoris", "quadriceps femoris tendon", "quadriceps tendon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "common quadriceps femoris tendon", "common quadriceps tendon", "common tendon of quadriceps femoris muscle complex" ; oboInOwl:id "UBERON:0014848" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "tendon of quadriceps femoris" ; rdfs:subClassOf obo:UBERON_0000043, _:genid156817 . obo:UBERON_0014851 obo:IAO_0000115 "Chorda tendinea which is attached to the leaflet of mitral valve and is continuous with the endocardium of papillary muscle of left ventricle." ; oboInOwl:hasDbXref "FMA:9349" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014851" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chorda tendinea of left ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005994 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0014852 obo:IAO_0000115 "Chorda tendinea which is attached to the leaflet of tricuspid valve and is continuous with the endocardium of papillary muscle of right ventricle." ; oboInOwl:hasDbXref "FMA:9300" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014852" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chorda tendinea of right ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005994 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0014871 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of pedal digit 1." ; oboInOwl:hasDbXref "FMA:33036" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of big toe", "distal epiphysis of distal phalanx of big toe", "distal epiphysis of distal phalanx of pedal digit I", "head of distal phalanx of big toe", "head of distal phalanx of first digit of foot", "head of distal phalanx of great toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of big toe" ; oboInOwl:id "UBERON:0014871" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004315 ] ) ] . obo:UBERON_0014872 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of pedal digit 2." ; oboInOwl:hasDbXref "FMA:33045" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of second toe", "distal epiphysis of distal phalanx of pedal digit II", "distal epiphysis of distal phalanx of second toe", "head of distal phalanx of second toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of second toe" ; oboInOwl:id "UBERON:0014872" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004316 ] ) ] . obo:UBERON_0014873 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of pedal digit 3." ; oboInOwl:hasDbXref "FMA:33054" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of third toe", "distal epiphysis of distal phalanx of pedal digit III", "distal epiphysis of distal phalanx of third toe", "head of distal phalanx of third digit of foot", "head of distal phalanx of third toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of third toe" ; oboInOwl:id "UBERON:0014873" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004317 ] ) ] . obo:UBERON_0014874 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of pedal digit 4." ; oboInOwl:hasDbXref "FMA:33091" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of fourth toe", "distal epiphysis of distal phalanx of fourth toe", "distal epiphysis of distal phalanx of pedal digit IV", "head of distal phalanx of fourth digit of foot", "head of distal phalanx of fourth toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungal tuberosity of distal phalanx of fourth toe" ; oboInOwl:id "UBERON:0014874" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004318 ] ) ] . obo:UBERON_0014875 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of pedal digit 5." ; oboInOwl:hasDbXref "FMA:33106" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of little toe", "distal epiphysis of distal phalanx of little toe", "distal epiphysis of distal phalanx of pedal digit V", "head of distal phalanx of fifth digit of foot", "head of distal phalanx of fifth toe", "head of distal phalanx of little toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of fifth toe" ; oboInOwl:id "UBERON:0014875" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004319 ] ) ] . obo:UBERON_0014876 oboInOwl:hasExactSynonym "distal end of distal phalanx of toe", "head of distal phalanx of digit of foot", "head of distal phalanx of digit of pes", "head of distal phalanx of toe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014876" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of pedal digit" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003867 ] ) ] . obo:UBERON_0014881 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of manual digit 1." ; oboInOwl:hasDbXref "FMA:37609", "SCTID:182011000" ; oboInOwl:hasExactSynonym "distal end of phalanx of right thumb", "distal epiphysis of distal phalanx of manual digit I", "distal epiphysis of distal phalanx of thumb", "head of distal phalanx of first digit of hand", "head of distal phalanx of thumb" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of thumb" ; oboInOwl:id "UBERON:0014881" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004337 ] ) ] . obo:UBERON_0014882 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of manual digit 2." ; oboInOwl:hasDbXref "FMA:37621", "SCTID:263457005" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of index finger", "distal end of distal phalanx of second finger", "distal epiphysis of distal phalanx of index finger", "distal epiphysis of distal phalanx of manual digit II", "head of distal phalanx of index finger", "head of distal phalanx of second finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of index finger" ; oboInOwl:id "UBERON:0014882" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004311 ] ) ] . obo:UBERON_0014883 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of manual digit 3." ; oboInOwl:hasDbXref "FMA:37633", "SCTID:263458000" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of middle finger", "distal end of distal phalanx of third finger", "distal epiphysis of distal phalanx of manual digit III", "distal epiphysis of distal phalanx of middle finger", "head of distal phalanx of middle finger", "head of distal phalanx of third digit of hand", "head of distal phalanx of third finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of middle finger" ; oboInOwl:id "UBERON:0014883" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit 3" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004312 ] ) ] . obo:UBERON_0014884 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of manual digit 4." ; oboInOwl:hasDbXref "FMA:37645", "SCTID:263459008" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of fourth finger", "distal end of distal phalanx of ring finger", "distal epiphysis of distal phalanx of manual digit IV", "distal epiphysis of distal phalanx of ring finger", "head of distal phalanx of fourth digit of hand", "head of distal phalanx of fourth finger", "head of distal phalanx of ring finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of ring finger" ; oboInOwl:id "UBERON:0014884" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit 4" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004313 ] ) ] . obo:UBERON_0014885 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx of manual digit 5." ; oboInOwl:hasDbXref "FMA:37657", "SCTID:263460003" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of fifth finger", "distal end of distal phalanx of little finger", "distal epiphysis of distal phalanx of little finger", "distal epiphysis of distal phalanx of manual digit V", "head of distal phalanx of fifth digit of hand", "head of distal phalanx of fifth finger", "head of distal phalanx of little finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ungual tuberosity of distal phalanx of little finger" ; oboInOwl:id "UBERON:0014885" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit 5" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004314 ] ) ] . obo:UBERON_0014886 oboInOwl:hasDbXref "SCTID:182006002" ; oboInOwl:hasExactSynonym "distal end of distal phalanx of finger", "head of distal phalanx of digit of hand", "head of distal phalanx of digit of manus", "head of distal phalanx of finger" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014886" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of manual digit" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003865 ] ) ] . obo:UBERON_0014887 obo:IAO_0000115 "A distal epiphysis that is part of a distal phalanx." ; oboInOwl:hasExactSynonym "distal end of distal phalanx of digit", "head of distal phalanx", "head of distal phalanx of digit", "head of distal phalanx of digit of autopod" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014887" ; a owl:Class ; rdfs:label "distal epiphysis of distal phalanx of digit" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004379 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004300 ] ) ] . obo:UBERON_0014889 obo:IAO_0000115 "A cerebellar hemisphere that is in_the_left_side_of a cerebellum." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:83877" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014889" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "left hemisphere of cerebellum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002245 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0014890 obo:IAO_0000115 "A cerebellar hemisphere that is in_the_right_side_of a cerebellum." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:83876" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014890" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "right hemisphere of cerebellum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002245 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0014891 obo:IAO_0000115 "White matter that is part of a brainstem [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35189", "FMA:282112", "MA:0002741", "SCTID:360442003" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "brain stem white matter", "brainstem tract/commissure", "brainstem tracts", "brainstem tracts and commissures" ; oboInOwl:id "UBERON:0014891" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "brainstem white matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002298 ] ) ] . obo:UBERON_0014892 obo:IAO_0000115 "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." ; oboInOwl:hasBroadSynonym "skeletal muscle" ; oboInOwl:hasDbXref "AAO:0011099", "BTO:0001103", "CALOHA:TS-0933", "EFO:0000888", "EHDAA:5035", "EHDAA:5043", "EHDAA:5978", "EHDAA:5984", "EMAPA:35988", "EV:0100377", "GAID:141", "MA:0003148", "MAT:0000302", "MESH:D018482", "MIAA:0000302", "TAO:0005277", "VHOG:0000319", "XAO:0000174", "ZFA:0005277" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014892" ; a owl:Class ; rdfs:label "skeletal muscle organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0018254 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 _:genid154777 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003082 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0011899 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001134 ] ) ] . obo:UBERON_0014903 obo:IAO_0000115 "A portion of tissue that will develop into vasculature." ; oboInOwl:hasDbXref "EFO:0003708", "TAO:0005076", "ZFA:0005076" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014903" ; a owl:Class ; rdfs:label "primordial vasculature" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011695 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002049 ] ) ] . obo:UBERON_0014907 obo:IAO_0000115 "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." ; obo:UBPROP_0000001 "Blood vessels that connect the dorsal aorta or the posterior cardinal vein and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these don't have venous or arterial markers[ZFA:0001285, ZFIN:ZDB-PUB-030908-4]." ; oboInOwl:hasDbXref "EFO:0003664", "EMAPA:37389", "TAO:0001285", "XAO:0004075", "ZFA:0001285" ; oboInOwl:hasExactSynonym "intersegmental vessel", "intersegmental vessels", "intersomitic blood vessel", "intersomitic vessels", "segmental vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014907" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "intersomitic vessel" ; rdfs:subClassOf obo:UBERON_0001981, _:genid157000 . obo:UBERON_0014930 obo:IAO_0000115 "The space between a blood vessel and the pia mater." ; oboInOwl:hasBroadSynonym "VRS" ; oboInOwl:hasDbXref "NCIT:C83196", "SCTID:342298001", "UMLS:C0225983", "Wikipedia:Virchow-Robin_space" ; oboInOwl:hasExactSynonym "Virchow-Robin space", "perivascular region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "perivascular spaces" ; oboInOwl:id "UBERON:0014930" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "VRS belonging to the subarachnoid space are continuous with VRS of the subpial space. The direct communication between VRS of the subarachnoid space and the subpial space is unique to the brain's arteries, as no leptomeningeal layers surround the brain's veins[WP]" ; rdfs:label "perivascular space" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010743 ], _:genid154810 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001981 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002361 ] ) ] ; foaf:depicted_by "https://static-content.springer.com/image/art%3A10.1007%2Fs11064-015-1581-6/MediaObjects/11064_2015_1581_Fig3_HTML.gif"^^xsd:anyURI . obo:UBERON_0014932 oboInOwl:hasDbXref "SCTID:37065005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014932" ; a owl:Class ; rdfs:label "periventricular white matter" ; rdfs:subClassOf obo:UBERON_0002316, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004086 ] . obo:UBERON_0014950 obo:IAO_0000232 "these layers primarily refer to the mammalian future neocortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0014950" ; a owl:Class ; rdfs:label "layer of developing cerebral cortex" ; rdfs:subClassOf obo:UBERON_0005423, _:genid157023 . obo:UBERON_0015001 obo:IAO_0000115 "The major preaxial endrochondral skeletal element in the anterior zeugopod." ; oboInOwl:hasBroadSynonym "radius skeletal element" ; oboInOwl:hasExactSynonym "radius element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015001" ; a owl:Class ; rdfs:label "radius endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001423 obo:UBERON_0006286 obo:UBERON_0010846 ) ] . obo:UBERON_0015002 obo:IAO_0000115 "A radius-ulna bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "radius-ulna skeletal element" ; oboInOwl:hasExactSynonym "radius-ulna element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015002" ; a owl:Class ; rdfs:label "radius-ulna endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006287 obo:UBERON_0006715 obo:UBERON_0010848 ) ] . obo:UBERON_0015003 obo:IAO_0000115 "Major postaxial endrochondral skeletal element in the anterior zeugopod." ; oboInOwl:hasBroadSynonym "ulna skeletal element" ; oboInOwl:hasExactSynonym "ulna element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015003" ; a owl:Class ; rdfs:comment "The corresponding element in the posterior fin/limb is the fibula." ; rdfs:label "ulna endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001424 obo:UBERON_0006306 obo:UBERON_0010847 ) ] . obo:UBERON_0015004 obo:IAO_0000115 "The major preaxial endochondral element in the posterior zeugopod[Phenoscape]." ; oboInOwl:hasBroadSynonym "tibia skeletal element" ; oboInOwl:hasExactSynonym "tibia element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015004" ; a owl:Class ; rdfs:label "tibia endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0000979 obo:UBERON_0010849 obo:UBERON_0010850 ) ] . obo:UBERON_0015007 obo:IAO_0000115 "A vertebral endochondral element in the cervical region of the vertebral column." ; oboInOwl:hasBroadSynonym "cervical vertebra skeletal element" ; oboInOwl:hasExactSynonym "cervical vertebra element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015007" ; a owl:Class ; rdfs:label "cervical vertebra endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006072 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002413 obo:UBERON_0013505 obo:UBERON_0013506 ) ] . obo:UBERON_0015008 obo:IAO_0000115 "A vertebral endochondral element in the thoracic region of the vertebral column." ; oboInOwl:hasBroadSynonym "thoracic vertebra skeletal element" ; oboInOwl:hasExactSynonym "thoracic vertebra element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015008" ; a owl:Class ; rdfs:label "thoracic vertebra endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006073 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002347 obo:UBERON_0013507 obo:UBERON_0013508 ) ] . obo:UBERON_0015009 obo:IAO_0000115 "A lumbar vertebra bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "lumbar vertebra skeletal element" ; oboInOwl:hasExactSynonym "lumbar vertebra element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015009" ; a owl:Class ; rdfs:label "lumbar vertebra endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006074 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002414 obo:UBERON_0013509 obo:UBERON_0013510 ) ] . obo:UBERON_0015010 obo:IAO_0000115 "A vertebra endochondral element that is part of the sacral region of the vertebral column." ; oboInOwl:hasBroadSynonym "sacral vertebra skeletal element" ; oboInOwl:hasExactSynonym "sacral vertebra element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015010" ; a owl:Class ; rdfs:label "sacral vertebra endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006075 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001094 obo:UBERON_0010744 obo:UBERON_0010745 ) ] . obo:UBERON_0015013 obo:IAO_0000115 "The major postaxial endochondral element in the posterior zeugopod[Phenoscape]." ; oboInOwl:hasBroadSynonym "fibula skeletal element" ; oboInOwl:hasExactSynonym "fibula element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015013" ; a owl:Class ; rdfs:label "fibula endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010720 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001446 obo:UBERON_0010851 obo:UBERON_0010852 ) ] . obo:UBERON_0015014 obo:IAO_0000115 "A calcaneum bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "calcaneum skeletal element" ; oboInOwl:hasExactSynonym "calcaneum element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015014" ; a owl:Class ; rdfs:label "calcaneum endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001450 obo:UBERON_0010801 obo:UBERON_0010842 ) ] . obo:UBERON_0015016 obo:IAO_0000115 "A stapes bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "stapes skeletal element" ; oboInOwl:hasExactSynonym "stapes element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015016" ; a owl:Class ; rdfs:label "stapes endochondral element" ; rdfs:subClassOf obo:UBERON_0035130 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001687 obo:UBERON_0006294 obo:UBERON_0010055 ) ] . obo:UBERON_0015017 obo:IAO_0000115 "An incus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "incus skeletal element" ; oboInOwl:hasExactSynonym "incus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015017" ; a owl:Class ; rdfs:label "incus endochondral element" ; rdfs:subClassOf obo:UBERON_0035130 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001688 obo:UBERON_0006248 obo:UBERON_0007374 ) ] . obo:UBERON_0015018 obo:IAO_0000115 "A malleus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "malleus skeletal element" ; oboInOwl:hasExactSynonym "malleus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "malleus" ; oboInOwl:id "UBERON:0015018" ; a owl:Class ; rdfs:label "malleus endochondral element" ; rdfs:subClassOf obo:UBERON_0035130 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001689 obo:UBERON_0006262 obo:UBERON_0010054 ) ] . obo:UBERON_0015019 obo:IAO_0000115 "A rib bone or its cartilage or pre-cartilage precursor." ; obo:UBPROP_0000008 "Humans have 24 ribs (12 pairs). The first seven sets of ribs, known as 'true ribs', are directly attached to the sternum through the costal cartilage. The following five sets are known as 'false ribs', three of these sharing a common cartilaginous connection to the sternum, while the last two (eleventh and twelfth ribs) are termed floating ribs (costae fluitantes) or vertebral ribs. They are attached to the vertebrae only, and not to the sternum or cartilage coming off of the sternum. Some people are missing one of the two pairs of floating ribs, while others have a third pair. Rib removal is the surgical excision of ribs for therapeutic or cosmetic reasons. In fish, there are often two sets of ribs attached to the vertebral column. One set, the dorsal ribs, are found in the dividing septum between the upper and lower parts of the main muscle segments, projecting roughly sideways from the vertebral column. The second set, of ventral ribs arise from the vertebral column just below the dorsal ribs, and enclose the lower body, often joining at the tips. Not all species possess both types of rib, with the dorsal ribs being most commonly absent. Sharks, for example, have no dorsal ribs, and only very short ventral ribs, while lampreys have no ribs at all. In some teleosts, there may be additional rib-like bones within the muscle mass. Tetrapods, however, only ever have a single set of ribs which are probably homologous with the dorsal ribs of fishes. In the early tetrapods, every vertebra bore a pair of ribs, although those on the thoracic vertebrae are typically the longest. The sacral ribs were stout and short, since they formed part of the pelvis, connecting the backbone to the hip bones.[1] In most subsequent forms, many of these early ribs have been lost, and in living amphibians and reptiles, there is great variation in rib structure and number. For example, turtles have only eight pairs of ribs, which are developed into a bony or cartilagenous carapace and plastron, while snakes have numerous ribs running along the full length of their trunk. Frogs typically have no ribs, aside from a sacral pair, which form part of the pelvis.[1]. In birds, ribs are present as distinct bones only on the thoracic region, although small fused ribs are present on the cervical vertebrae. The thoracic ribs of birds possess a wide projection to the rear; this uncinate process is an attachment for the shoulder muscles.[1]. Mammals usually also only have distinct ribs on the thoracic vertebra, although fixed cervical ribs are also present in monotremes. In marsupials and placental mammals, the cervical and lumbar ribs are found only as tiny remnants fused to the vertebrae, where they are referred to as transverse processes. In general, the structure and number of the true ribs in humans is similar to that in other mammals. Unlike reptiles, caudal ribs are never found in mammals." ; oboInOwl:hasBroadSynonym "rib skeletal element" ; oboInOwl:hasExactSynonym "rib element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015019" ; a owl:Class ; rdfs:label "rib endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014478 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0002228 obo:UBERON_0006288 obo:UBERON_0006289 ) ] . obo:UBERON_0015021 obo:IAO_0000115 "A forelimb bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "forelimb skeletal element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015021" ; a owl:Class ; rdfs:label "forelimb endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0008962 obo:UBERON_0010883 obo:UBERON_0010884 ) ] . obo:UBERON_0015022 obo:IAO_0000115 "A hindlimb bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "hindlimb bone skeletal element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015022" ; a owl:Class ; rdfs:label "hindlimb endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003464 obo:UBERON_0010885 obo:UBERON_0010886 ) ] . obo:UBERON_0015023 obo:IAO_0000115 "A phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "phalanx skeletal element" ; oboInOwl:hasExactSynonym "phalanx element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015023" ; a owl:Class ; rdfs:label "phalanx endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0003221 obo:UBERON_0010700 obo:UBERON_0010701 ) ] . obo:UBERON_0015024 obo:IAO_0000115 "A manual digit phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit phalanx element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015024" ; a owl:Class ; rdfs:label "manual digit phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010688 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5102389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001436 obo:UBERON_0010586 obo:UBERON_0010686 ) ] . obo:UBERON_0015025 obo:IAO_0000115 "A manual digit 1 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 1 phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit 1 phalanx element", "manual digit I phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015025" ; a owl:Class ; rdfs:label "manual digit 1 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003620 obo:UBERON_0010575 obo:UBERON_0010675 ) ] . obo:UBERON_0015026 obo:IAO_0000115 "A manual digit 2 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 2 phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit 2 phalanx element", "manual digit II phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015026" ; a owl:Class ; rdfs:label "manual digit 2 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ] ; owl:equivalentClass _:genid154996, [ a owl:Class ; owl:unionOf (obo:UBERON_0003636 obo:UBERON_0010576 obo:UBERON_0010676 ) ] . obo:UBERON_0015027 obo:IAO_0000115 "A manual digit 3 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 3 phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit 3 phalanx element", "manual digit III phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015027" ; a owl:Class ; rdfs:label "manual digit 3 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003637 obo:UBERON_0010577 obo:UBERON_0010677 ) ] . obo:UBERON_0015028 obo:IAO_0000115 "A manual digit 4 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 4 phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit 4 phalanx element", "manual digit IV phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015028" ; a owl:Class ; rdfs:label "manual digit 4 phalanx endochondral element" ; rdfs:subClassOf _:genid155030 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003638 obo:UBERON_0010578 obo:UBERON_0010678 ) ] . obo:UBERON_0015029 obo:IAO_0000115 "A manual digit 5 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 5 phalanx skeletal element" ; oboInOwl:hasExactSynonym "manual digit 5 phalanx element", "manual digit V phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015029" ; a owl:Class ; rdfs:label "manual digit 5 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 _:genid155037 ) ], _:genid155039 . obo:UBERON_0015030 obo:IAO_0000115 "A pedal digit phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit phalanx element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015030" ; a owl:Class ; rdfs:label "pedal digit phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010696 ], _:genid155057 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001466 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001449 obo:UBERON_0010585 obo:UBERON_0010685 ) ] . obo:UBERON_0015031 obo:IAO_0000115 "A pedal digit 1 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 1 phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 1 phalanx element", "pedal digit I phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015031" ; a owl:Class ; rdfs:label "pedal digit 1 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103631 ] ; owl:equivalentClass _:genid155061, [ a owl:Class ; owl:unionOf (obo:UBERON_0003640 obo:UBERON_0010580 obo:UBERON_0010680 ) ] . obo:UBERON_0015032 obo:IAO_0000115 "A pedal digit 2 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 2 phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 2 phalanx element", "pedal digit II phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015032" ; a owl:Class ; rdfs:label "pedal digit 2 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003632 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003641 obo:UBERON_0010581 obo:UBERON_0010681 ) ] . obo:UBERON_0015033 obo:IAO_0000115 "A pedal digit 3 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 3 phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 3 phalanx element", "pedal digit III phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015033" ; a owl:Class ; rdfs:label "pedal digit 3 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103633 ] ; owl:equivalentClass _:genid155087, [ a owl:Class ; owl:unionOf (obo:UBERON_0003642 obo:UBERON_0010582 obo:UBERON_0010682 ) ] . obo:UBERON_0015034 obo:IAO_0000115 "A pedal digit 4 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 4 phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 4 phalanx element", "pedal digit IV phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015034" ; a owl:Class ; rdfs:label "pedal digit 4 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003862 obo:UBERON_0010583 obo:UBERON_0010683 ) ] . obo:UBERON_0015035 obo:IAO_0000115 "A pedal digit 5 phalanx bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 5 phalanx skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 5 phalanx element", "pedal digit V phalanx endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015035" ; a owl:Class ; rdfs:label "pedal digit 5 phalanx endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003863 obo:UBERON_0010584 obo:UBERON_0010684 ) ] . obo:UBERON_0015036 obo:IAO_0000115 "A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit metatarsal element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015036" ; a owl:Class ; rdfs:label "pedal digit metatarsal endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012152 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000983 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0010545 obo:UBERON_0010687 obo:UBERON_0010697 ) ] . obo:UBERON_0015037 obo:IAO_0000115 "A pedal digit 1 metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 1 metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 1 metatarsal element", "pedal digit I metatarsal endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015037" ; a owl:Class ; rdfs:label "pedal digit 1 metatarsal endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103631 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003650 obo:UBERON_0010547 obo:UBERON_0010557 ) ] . obo:UBERON_0015038 obo:IAO_0000115 "A pedal digit 2 metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 2 metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 2 metatarsal element", "pedal digit II metatarsal endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015038" ; a owl:Class ; rdfs:label "pedal digit 2 metatarsal endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103632 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003651 obo:UBERON_0010548 obo:UBERON_0010558 ) ] . obo:UBERON_0015039 obo:IAO_0000115 "A pedal digit 3 metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 3 metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 3 metatarsal element", "pedal digit III metatarsal endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015039" ; a owl:Class ; rdfs:label "pedal digit 3 metatarsal endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103633 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003652 obo:UBERON_0010549 obo:UBERON_0010559 ) ] . obo:UBERON_0015040 obo:IAO_0000115 "A pedal digit 4 metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 4 metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 4 metatarsal element", "pedal digit IV metatarsal endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015040" ; a owl:Class ; rdfs:label "pedal digit 4 metatarsal endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103634 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003653 obo:UBERON_0010550 obo:UBERON_0010560 ) ] . obo:UBERON_0015041 obo:IAO_0000115 "A pedal digit 5 metatarsal bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pedal digit 5 metatarsal skeletal element" ; oboInOwl:hasExactSynonym "pedal digit 5 metatarsal element", "pedal digit V metatarsal endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015041" ; a owl:Class ; rdfs:label "pedal digit 5 metatarsal endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103635 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003654 obo:UBERON_0010551 obo:UBERON_0010561 ) ] . obo:UBERON_0015042 obo:IAO_0000115 "A manual digit metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit metacarpus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015042" ; a owl:Class ; rdfs:label "manual digit metacarpus endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012151 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004453 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0010544 obo:UBERON_0010698 obo:UBERON_0010699 ) ] . obo:UBERON_0015043 obo:IAO_0000115 "A manual digit 1 metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 1 metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit 1 metacarpus element", "manual digit I metacarpus endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015043" ; a owl:Class ; rdfs:label "manual digit 1 metacarpus endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5101463 ] ) ], [ a owl:Class ; owl:unionOf _:genid155215 ] . obo:UBERON_0015044 obo:IAO_0000115 "A manual digit 2 metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 2 metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit 2 metacarpus element", "manual digit II metacarpus endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015044" ; a owl:Class ; rdfs:label "manual digit 2 metacarpus endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103622 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003646 obo:UBERON_0010566 obo:UBERON_0010571 ) ] . obo:UBERON_0015045 obo:IAO_0000115 "A manual digit 3 metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 3 metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit 3 metacarpus element", "manual digit III metacarpus endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015045" ; a owl:Class ; rdfs:label "manual digit 3 metacarpus endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103623 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003647 obo:UBERON_0010567 obo:UBERON_0010572 ) ] . obo:UBERON_0015046 obo:IAO_0000115 "A manual digit 4 metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 4 metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit 4 metacarpus element", "manual digit IV metacarpus endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015046" ; a owl:Class ; rdfs:label "manual digit 4 metacarpus endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103624 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0003648 obo:UBERON_0010568 obo:UBERON_0010573 ) ] . obo:UBERON_0015047 obo:IAO_0000115 "A manual digit 5 metacarpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "manual digit 5 metacarpus skeletal element" ; oboInOwl:hasExactSynonym "manual digit 5 metacarpus element", "manual digit V metacarpus endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015047" ; a owl:Class ; rdfs:label "manual digit 5 metacarpus endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5103625 ] ) ], [ a owl:Class ; owl:unionOf _:genid155263 ] . obo:UBERON_0015049 obo:IAO_0000115 "A carpus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "carpus skeletal element" ; oboInOwl:hasExactSynonym "carpus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015049" ; a owl:Class ; rdfs:label "carpus endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001435 obo:UBERON_0006213 obo:UBERON_0006214 ) ] . obo:UBERON_0015050 obo:IAO_0000115 "A tarsus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "tarsus skeletal element" ; oboInOwl:hasExactSynonym "tarsus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015050" ; a owl:Class ; rdfs:label "tarsus endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001447 obo:UBERON_0010540 obo:UBERON_0010541 ) ] . obo:UBERON_0015052 obo:IAO_0000115 "A femur bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "femur skeletal element" ; oboInOwl:hasExactSynonym "femur element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015052" ; a owl:Class ; rdfs:label "femur endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0000981 obo:UBERON_0006234 obo:UBERON_0010129 ) ] . obo:UBERON_0015053 obo:IAO_0000115 "A humerus bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "humerus skeletal element" ; oboInOwl:hasExactSynonym "humerus element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015053" ; a owl:Class ; rdfs:label "humerus endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0000976 obo:UBERON_0006245 obo:UBERON_0006246 ) ] . obo:UBERON_0015054 obo:IAO_0000115 "An iliac bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "iliac skeletal element" ; oboInOwl:hasExactSynonym "iliac element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015054" ; a owl:Class ; rdfs:label "iliac endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001273 obo:UBERON_0006247 obo:UBERON_0010714 ) ] . obo:UBERON_0015055 obo:IAO_0000115 "A pubic bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "pubic skeletal element" ; oboInOwl:hasExactSynonym "pubic element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015055" ; a owl:Class ; rdfs:label "pubic endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001275 obo:UBERON_0006285 obo:UBERON_0010718 ) ] . obo:UBERON_0015056 obo:IAO_0000115 "An ischial bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "ischial skeletal element" ; oboInOwl:hasExactSynonym "ischial element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015056" ; a owl:Class ; rdfs:label "ischial endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001274 obo:UBERON_0006254 obo:UBERON_0006255 ) ] . obo:UBERON_0015057 obo:IAO_0000115 "A scapula bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "scapula skeletal element" ; oboInOwl:hasExactSynonym "scapula element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015057" ; a owl:Class ; rdfs:label "scapula endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006290 obo:UBERON_0006291 obo:UBERON_0006849 ) ] . obo:UBERON_0015059 obo:IAO_0000115 "An orbitosphenoid bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "orbitosphenoid skeletal element" ; oboInOwl:hasExactSynonym "orbitosphenoid element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015059" ; a owl:Class ; rdfs:label "orbitosphenoid endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003111 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0002478 obo:UBERON_0005687 obo:UBERON_0010728 ) ] . obo:UBERON_0015060 obo:IAO_0000115 "A sphenoid bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "sphenoid bone skeletal element" ; oboInOwl:hasExactSynonym "sphenoid element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015060" ; a owl:Class ; rdfs:label "sphenoid endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001677 obo:UBERON_0009191 obo:UBERON_0009193 ) ] . obo:UBERON_0015061 obo:IAO_0000115 "A limb bone or its cartilage or pre-cartilage precursor." ; oboInOwl:hasBroadSynonym "limb bone skeletal element" ; oboInOwl:hasExactSynonym "limb bone endochondral element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015061" ; a owl:Class ; rdfs:label "limb endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004381 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002428 obo:UBERON_0010881 obo:UBERON_0010882 ) ] . obo:UBERON_0015063 obo:IAO_0000115 "An endochondral element that is part of a autopod region." ; obo:UBPROP_0000006 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015063" ; a owl:Class ; rdfs:label "autopod endochondral element" ; rdfs:subClassOf _:genid157585 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] ) ] . obo:UBERON_0015064 obo:IAO_0000115 "An autopod endochondral element that is composed primarily of cartilage tissue." ; obo:UBPROP_0000006 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015064" ; a owl:Class ; rdfs:label "autopod cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015063 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015067 obo:IAO_0000115 "Endochondral element located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE]." ; obo:IAO_0000232 "This term corresponds both to the navicular bone in the pes and the similar central carpals in the manus" ; obo:UBPROP_0000012 "the FMA term is under 'general anatomical term'." ; oboInOwl:hasExactSynonym "central mesopodium element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "centralia" ; oboInOwl:id "UBERON:0015067" ; a owl:Class ; rdfs:label "centrale endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009878 ] . obo:UBERON_0015068 obo:IAO_0000115 "A distal mesopodial endochondral element that is part of a forelimb." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal carpal" ; oboInOwl:id "UBERON:0015068" ; a owl:Class ; rdfs:label "distal carpal endochondral element" ; rdfs:subClassOf _:genid157602 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018099 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0015069 obo:IAO_0000115 "A distal carpal endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015069" ; a owl:Class ; rdfs:label "distal carpal cartilage element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015068 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015077 obo:IAO_0000115 "A centrale endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015077" ; a owl:Class ; rdfs:label "centrale cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015067 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015078 obo:IAO_0000115 "A proximal mesopodial endochondral element that is part of a forelimb." ; oboInOwl:hasExactSynonym "proximal carpal element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal carpal" ; oboInOwl:id "UBERON:0015078" ; a owl:Class ; rdfs:label "proximal carpal endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017750 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0015079 obo:IAO_0000115 "A proximal carpal endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015079" ; a owl:Class ; rdfs:label "proximal carpal cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015080 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015078 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015080 obo:IAO_0000115 "A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015080" ; a owl:Class ; rdfs:label "proximal carpal bone pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001442 ] ; owl:equivalentClass _:genid155421 . obo:UBERON_0015081 obo:IAO_0000115 "A proximal mesopodial endochondral element that is part of a hindlimb." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proximal tarsal" ; oboInOwl:id "UBERON:0015081" ; a owl:Class ; rdfs:label "proximal tarsal endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017750 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0015082 obo:IAO_0000115 "A proximal tarsal endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015082" ; a owl:Class ; rdfs:label "proximal tarsal cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015083 ] ; owl:equivalentClass _:genid155434 . obo:UBERON_0015083 obo:IAO_0000115 "A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015083" ; a owl:Class ; rdfs:label "proximal tarsal bone pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015081 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015084 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal carpal 1" ; oboInOwl:id "UBERON:0015084" ; a owl:Class ; rdfs:label "distal carpal bone 1 endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] . obo:UBERON_0015085 obo:IAO_0000115 "A distal carpal bone 1 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015085" ; a owl:Class ; rdfs:label "distal carpal bone 1 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015086 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015084 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015086 obo:IAO_0000115 "A distal carpal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015086" ; a owl:Class ; rdfs:label "distal carpal bone 1 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015084 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015087 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal carpal 2" ; oboInOwl:id "UBERON:0015087" ; a owl:Class ; rdfs:label "distal carpal bone 2 endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] . obo:UBERON_0015088 obo:IAO_0000115 "A distal carpal bone 2 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015088" ; a owl:Class ; rdfs:label "distal carpal bone 2 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015089 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015087 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015089 obo:IAO_0000115 "A distal carpal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015089" ; a owl:Class ; rdfs:label "distal carpal bone 2 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015087 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015090 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal carpal 3" ; oboInOwl:id "UBERON:0015090" ; a owl:Class ; rdfs:label "distal carpal bone 3 endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] . obo:UBERON_0015091 obo:IAO_0000115 "A distal carpal bone 3 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015091" ; a owl:Class ; rdfs:label "distal carpal bone 3 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015092 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015090 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015092 obo:IAO_0000115 "A distal carpal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015092" ; a owl:Class ; rdfs:label "distal carpal bone 3 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015090 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015093 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal carpal 4" ; oboInOwl:id "UBERON:0015093" ; a owl:Class ; rdfs:label "distal carpal bone 4 endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] . obo:UBERON_0015094 obo:IAO_0000115 "A distal carpal bone 4 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015094" ; a owl:Class ; rdfs:label "distal carpal bone 4 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015095 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015093 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015095 obo:IAO_0000115 "A distal carpal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015095" ; a owl:Class ; rdfs:label "distal carpal bone 4 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015093 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015099 obo:IAO_0000115 "A distal mesopodial endochondral element that is part of a hindlimb." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal" ; oboInOwl:id "UBERON:0015099" ; a owl:Class ; rdfs:label "distal tarsal endochondral element" ; rdfs:subClassOf _:genid157720 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018099 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0015100 obo:IAO_0000115 "A distal tarsal endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015100" ; a owl:Class ; rdfs:label "distal tarsal cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015101 obo:IAO_0000115 "A distal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015101" ; a owl:Class ; rdfs:label "distal tarsal bone pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015102 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal 1" ; oboInOwl:id "UBERON:0015102" ; a owl:Class ; rdfs:label "distal tarsal bone 1 endochondral element" ; rdfs:subClassOf obo:UBERON_0015099 . obo:UBERON_0015103 obo:IAO_0000115 "A distal tarsal bone 1 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasExactSynonym "distal tarsal 1 cartilage", "distal tarsal 1 cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015103" ; a owl:Class ; rdfs:label "distal tarsal bone 1 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015104 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015102 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015104 obo:IAO_0000115 "A distal tarsal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015104" ; a owl:Class ; rdfs:label "distal tarsal bone 1 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015102 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015105 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal 2" ; oboInOwl:id "UBERON:0015105" ; a owl:Class ; rdfs:label "distal tarsal bone 2 endochondral element" ; rdfs:subClassOf obo:UBERON_0015099 . obo:UBERON_0015106 obo:IAO_0000115 "A distal tarsal bone 2 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasExactSynonym "distal tarsal 2 cartilage", "distal tarsal 2 cartilage element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015106" ; a owl:Class ; rdfs:label "distal tarsal bone 2 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015107 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015105 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015107 obo:IAO_0000115 "A distal tarsal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015107" ; a owl:Class ; rdfs:label "distal tarsal bone 2 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015105 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015108 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal 3" ; oboInOwl:id "UBERON:0015108" ; a owl:Class ; rdfs:label "distal tarsal bone 3 endochondral element" ; rdfs:subClassOf obo:UBERON_0015099 . obo:UBERON_0015109 obo:IAO_0000115 "A distal tarsal bone 3 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015109" ; a owl:Class ; rdfs:label "distal tarsal bone 3 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015110 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015108 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015110 obo:IAO_0000115 "A distal tarsal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015110" ; a owl:Class ; rdfs:label "distal tarsal bone 3 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015108 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015111 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal 4" ; oboInOwl:id "UBERON:0015111" ; a owl:Class ; rdfs:label "distal tarsal bone 4 endochondral element" ; rdfs:subClassOf obo:UBERON_0015099 . obo:UBERON_0015112 obo:IAO_0000115 "A distal tarsal bone 4 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015112" ; a owl:Class ; rdfs:label "distal tarsal bone 4 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015113 ] ; owl:equivalentClass _:genid155573 . obo:UBERON_0015113 obo:IAO_0000115 "A distal tarsal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015113" ; a owl:Class ; rdfs:label "distal tarsal bone 4 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015111 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015114 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "distal tarsal 5" ; oboInOwl:id "UBERON:0015114" ; a owl:Class ; rdfs:label "distal tarsal bone 5 endochondral element" ; rdfs:subClassOf obo:UBERON_0015099 . obo:UBERON_0015115 obo:IAO_0000115 "A distal tarsal bone 5 endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015115" ; a owl:Class ; rdfs:label "distal tarsal bone 5 cartilage" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0015116 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015114 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0015116 obo:IAO_0000115 "A distal tarsal bone 5 endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015116" ; a owl:Class ; rdfs:label "distal tarsal bone 5 pre-cartilage condensation" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015114 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0015120 obo:IAO_0000115 "An outer canthus that is in_the_right_side_of a head." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:59317" ; oboInOwl:hasExactSynonym "right angle of eye", "right lateral palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral angle of right eye", "lateral canthus of right eye", "right lateral canthus" ; oboInOwl:id "UBERON:0015120" ; a owl:Class ; rdfs:label "right outer canthus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006726 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0015121 obo:IAO_0000115 "An outer canthus that is in_the_left_side_of a head." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; oboInOwl:hasDbXref "FMA:59318" ; oboInOwl:hasExactSynonym "left angle of eye", "left lateral palpebral commissure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral angle of left eye", "lateral canthus of left eye", "left lateral canthus" ; oboInOwl:id "UBERON:0015121" ; a owl:Class ; rdfs:label "left outer canthus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006726 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0015122 obo:IAO_0000115 "An anatomical line of the face that connects the two outer (lateral) canthi of the eye. The length of this line is known as the outer canthal distance." ; oboInOwl:hasExactSynonym "inter lateral canthal line", "inter outer canthal line" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015122" ; a owl:Class ; rdfs:label "anatomical line between outer canthi" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015120 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015121 ] ) ] . obo:UBERON_0015128 obo:IAO_0000116 "consider merging into myocardial compact layer" ; oboInOwl:hasDbXref "FMA:83105" ; oboInOwl:hasExactSynonym "perimysial connective tissue of subepicardium", "subepicardial connective tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015128" ; a owl:Class ; rdfs:label "subepicardial layer of epicardium" ; rdfs:subClassOf obo:UBERON_0001136, _:genid157839 . obo:UBERON_0015129 obo:IAO_0000115 "Visceral intrapericardial fat contiguous with the myocardial surface." ; oboInOwl:hasDbXref "FMA:9871", "SCTID:42267001" ; oboInOwl:hasExactSynonym "epicardial adipose tissue", "pericardial adipose tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015129" ; a owl:Class ; rdfs:label "epicardial fat" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015128 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_1000309 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002348 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002425 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0015130 obo:IAO_0000115 "A portion of connective tissue that is part of a prostate gland." ; oboInOwl:hasDbXref "FMA:74165" ; oboInOwl:hasExactSynonym "connective tissue of prostate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015130" ; a owl:Class ; rdfs:label "connective tissue of prostate gland" ; rdfs:subClassOf obo:UBERON_0011822 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0015142 obo:IAO_0000115 "A large fat pad that is located at the base of the abdominal wall, in the falciform ligament of the liver." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "falciform fat depot", "falciform ligament fat pad" ; oboInOwl:id "UBERON:0015142" ; a owl:Class ; rdfs:label "falciform fat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001247 ] ) ] . obo:UBERON_0015143 obo:IAO_0000115 "Encapsulated adipose tissue associated with the mesentery." ; oboInOwl:hasExactSynonym "mesenteric fat depot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015143" ; a owl:Class ; rdfs:label "mesenteric fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ) ] . obo:UBERON_0015144 obo:IAO_0000115 "A strand of hair that is part of a autopod region." ; oboInOwl:hasExactSynonym "hair of hand/foot", "hand/foot hair" ; oboInOwl:hasNarrowSynonym "paw hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015144" ; a owl:Class ; rdfs:label "autopod hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid155661 ] . obo:UBERON_0015145 obo:IAO_0000115 "A strand of hair that is part of a pes." ; oboInOwl:hasExactSynonym "foot hair", "hair of foot", "hind foot hair" ; oboInOwl:hasNarrowSynonym "hind paw hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015145" ; a owl:Class ; rdfs:label "pes hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_0015146 obo:IAO_0000115 "A strand of hair that is part of a manus." ; oboInOwl:hasExactSynonym "hair of hand", "hand hair" ; oboInOwl:hasNarrowSynonym "front paw hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015146" ; a owl:Class ; rdfs:label "manus hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_0015147 obo:IAO_0000115 "A strand of hair that is part of a pinna." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ear hair" ; oboInOwl:id "UBERON:0015147" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pinna hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ] ) ] . obo:UBERON_0015148 obo:IAO_0000115 "A strand of hair that is part of a tail." ; oboInOwl:hasDbXref "EMAPA:37971" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015148" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "tail hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002415 ] ) ] . obo:UBERON_0015149 obo:IAO_0000115 "A strand of hair that is part of a ventrum." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventral coat hair" ; oboInOwl:id "UBERON:0015149" ; a owl:Class ; rdfs:label "ventral hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013235 ] ) ] . obo:UBERON_0015150 obo:IAO_0000115 "A strand of hair that is part of a dorsum." ; oboInOwl:hasDbXref "FMA:54320" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "back hair", "dorsal coat hair", "hair of back" ; oboInOwl:id "UBERON:0015150" ; a owl:Class ; rdfs:label "dorsal hair" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0015152 obo:IAO_0000115 "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." ; obo:UBPROP_0000008 "the only orbital gland found in anuran amphibians is either the Harderian or the lacrimal; if it is a lacrimal, then a progressive lateral migration of the lacrimal glands must occur through the amniotes[PMID:7559104]", "the only orbital gland found in anuran amphibians is the Harderian[PMID:8843648]" ; oboInOwl:hasExactSynonym "ocular gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "orbital gland" ; oboInOwl:id "UBERON:0015152" ; a owl:Class ; rdfs:label "gland of ocular region" ; rdfs:subClassOf _:genid157913 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ) ] . obo:UBERON_0015154 obo:IAO_0000115 "A gland that is located in or around the ocular region, nearer the outer canthi." ; obo:IAO_0000232 "The class name or definition should not be taken to mean strictly in the lateral ocular region. We place the extraocular lacrimal glands, even though they are as the name suggests outside the ocular region. The class exists as the division between lateral vs medial (Harderian, nictitans) glands is standard, e.g. http://www.ncbi.nlm.nih.gov/pubmed/7559104" ; oboInOwl:hasExactSynonym "lateral ocular gland", "lateral orbital gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015154" ; a owl:Class ; rdfs:label "lateral gland of orbital region" ; rdfs:subClassOf obo:UBERON_0015152 . obo:UBERON_0015155 obo:IAO_0000115 "An anatomical space that is enclosed by a conjunctiva." ; oboInOwl:hasDbXref "FMA:59083", "SCTID:280957009" ; oboInOwl:hasExactSynonym "cavity of conjunctival sac", "conjunctival sac cavity", "subconjunctival space" ; oboInOwl:hasNarrowSynonym "subbrillar space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015155" ; a owl:Class ; rdfs:label "conjunctival space" ; rdfs:subClassOf _:genid157921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001811 ] ) ] . obo:UBERON_0015156 obo:IAO_0000115 "The two terminal branches of the ophthalmic artery in humans are the dorsal nasal artery and the supratrochlear artery." ; oboInOwl:hasDbXref "FMA:51956" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015156" ; a owl:Class ; rdfs:label "terminal branch of ophthalmic artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001619 ] . obo:UBERON_0015161 obo:IAO_0000115 "The inferior branch of the oculomotor nerve or the inferior division, the larger, divides into three branches. One passes beneath the optic nerve to the medial rectus. Another, to the inferior rectus. The third and longest runs forward between the inferior recti and lateralis to the inferior oblique. From the last a short thick branch is given off to the lower part of the ciliary ganglion, and forms its short root. All these branches enter the muscles on their ocular surfaces, with the exception of the nerve to the inferior oblique, which enters the muscle at its posterior border." ; oboInOwl:hasDbXref "AAO:0010632", "FMA:52573", "SCTID:280206003", "Wikipedia:Inferior_branch_of_oculomotor_nerve", "neuronames:2232" ; oboInOwl:hasExactSynonym "inferior ramus of oculomotor nerve", "oculomotor nerve inferior division", "ramus inferior (nervus oculomotorius [III])", "ramus inferior nervi oculomotorii", "ramus inferior nervus oculomotorii" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inferior division of oculomotor nerve", "ventral ramus of occulomotor nerve", "ventral ramus of oculomotor nerve" ; oboInOwl:id "UBERON:0015161" ; a owl:Class ; rdfs:label "inferior branch of oculomotor nerve" ; rdfs:subClassOf _:genid157935 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001643 ] ) ] . obo:UBERON_0015165 obo:IAO_0000115 "An eye consisting of multiple light-sensing organs." ; obo:RO_0002175 obo:NCBITaxon_7588 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015165" ; a owl:Class ; rdfs:label "multi-unit eye" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000970 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000020 ] ) ] . obo:UBERON_0015172 obo:IAO_0000115 "A blood vessel that is part of a endometrium." ; oboInOwl:hasDbXref "SCTID:254200009" ; oboInOwl:hasExactSynonym "blood vessel of endometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015172" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "endometrial blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ] . obo:UBERON_0015178 obo:IAO_0000115 "A region of somite adjacent to presomitic mesoderm." ; oboInOwl:hasDbXref "TAO:0001462", "XAO:0004074", "ZFA:0001462" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "inter-somited border", "intersomitic boundary", "intersomitic fissure", "intersomitic junction", "segmental border", "somite boundary" ; oboInOwl:id "UBERON:0015178" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "somite border" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002329 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0003059 ] ) ] . obo:UBERON_0015179 obo:IAO_0000115 "Epithelium located in the intersomitic region." ; oboInOwl:hasDbXref "XAO:0004077" ; oboInOwl:hasExactSynonym "intersomitic epithelium", "intersomitic membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015179" ; a owl:Class ; rdfs:label "somite boundary epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015178 ] ) ] . obo:UBERON_0015180 obo:IAO_0000115 "The neck of talus is directed forward and medialward, and comprises the constricted portion of the bone between the body and the oval head. Its upper and medial surfaces are rough, for the attachment of ligaments; its lateral surface is concave and is continuous below with the deep groove for the interosseous talocalcaneal ligament." ; oboInOwl:hasDbXref "FMA:33636", "SCTID:182104001", "Wikipedia:Neck_of_talus" ; oboInOwl:hasExactSynonym "talar neck", "talus neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "collum tali" ; oboInOwl:id "UBERON:0015180" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "neck of talus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] . obo:UBERON_0015181 obo:IAO_0000115 "The slightly constricted part of a tooth, between the crown and the root." ; oboInOwl:hasDbXref "FMA:55627", "NCIT:C32346", "SCTID:28638008" ; oboInOwl:hasExactSynonym "cervix dentis", "cervix of tooth", "collumn dentis", "dental neck", "tooth neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cervical margin of tooth", "cervical zone of tooth" ; oboInOwl:id "UBERON:0015181" ; a owl:Class ; rdfs:label "neck of tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001091 ] ) ] . obo:UBERON_0015203 obo:IAO_0000115 "An anatomical group whose component structures share a common function." ; oboInOwl:hasDbXref "AEO:0000093", "FBbt:00007278" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015203" ; a owl:Class ; rdfs:label "non-connected functional system" ; rdfs:subClassOf obo:UBERON_0034923 . obo:UBERON_0015204 obo:IAO_0000115 "A non-connected functional system that is composed primarily of a gland." ; oboInOwl:hasDbXref "EHDAA2:0002223" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015204" ; a owl:Class ; rdfs:label "glandular system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015203 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002530 ] ) ] . obo:UBERON_0015212 obo:IAO_0000115 "Any structure that is placed on one side of the left-right axis of a bilaterian." ; obo:IAO_0000232 "This class is primarily to implement taxon constraints. It may be removed in the future." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015212" ; oboInOwl:inSubset core:grouping_class, core:non_informative ; a owl:Class ; rdfs:label "lateral structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000465 ] ) ] . obo:UBERON_0015214 obo:IAO_0000115 "A ligament that is part of a diaphragm." ; oboInOwl:hasDbXref "EMAPA:19236", "FMA:58280" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015214" ; a owl:Class ; rdfs:label "arcuate ligament" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001103 ] ) ] . obo:UBERON_0015228 obo:IAO_0000115 "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." ; oboInOwl:hasBroadSynonym "heart" ; oboInOwl:hasDbXref "SPD:0000130" ; oboInOwl:hasExactSynonym "cardiac pump", "heart or heart like organ" ; oboInOwl:hasNarrowSynonym "circulatory vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cardiac structure" ; oboInOwl:id "UBERON:0015228" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "circulatory organ" ; rdfs:subClassOf obo:UBERON_0003103, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001690 ] . obo:UBERON_0015233 obo:IAO_0000115 "A nucleus of brain that is part of a dorsal thalamus." ; oboInOwl:hasExactSynonym "dorsal thalamic nucleus", "nucleus of thalamus proper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015233" ; a owl:Class ; rdfs:label "nucleus of dorsal thalamus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004703 ] ) ] . obo:UBERON_0015238 obo:IAO_0000115 "A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals." ; oboInOwl:hasDbXref "TAO:0001359", "ZFA:0001359" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015238" ; a owl:Class ; rdfs:label "pineal complex" ; rdfs:subClassOf obo:UBERON_0000477, _:genid158017 . obo:UBERON_0015249 obo:IAO_0000115 "A zone of skin that is part of a digit [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32615", "MA:0003011" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015249" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "digit skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] . obo:UBERON_0015251 oboInOwl:hasDbXref "EMAPA:37680", "MA:0003043" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015251" ; a owl:Class ; rdfs:label "modified sebaceous gland" ; rdfs:subClassOf obo:UBERON_0001821 . obo:UBERON_0015280 obo:IAO_0000115 "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." ; oboInOwl:hasDbXref "EMAPA:37711", "MA:0000722" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015280" ; a owl:Class ; rdfs:label "pancreas left lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007324 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:UBERON_0015281 obo:IAO_0000115 "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." ; oboInOwl:hasDbXref "EMAPA:37712", "MA:0000723" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015281" ; a owl:Class ; rdfs:label "pancreas right lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007324 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000017 ] ) ] . obo:UBERON_0015329 obo:IAO_0000115 "A basement membrane of epithelium that is part of a respiratory system." ; oboInOwl:hasDbXref "EMAPA:37570", "MA:0001815" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015329" ; a owl:Class ; rdfs:label "respiratory system basement membrane" ; rdfs:subClassOf _:genid158043 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0015410 oboInOwl:hasDbXref "EMAPA:37597", "MA:0002449" ; oboInOwl:hasExactSynonym "heart/pericardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015410" ; a owl:Class ; rdfs:label "heart plus pericardium" ; rdfs:subClassOf obo:UBERON_0005178, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 ] . obo:UBERON_0015418 obo:IAO_0000115 "A mesenchyme that is part of a urethra." ; oboInOwl:hasDbXref "EMAPA:37786", "MA:0002648" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015418" ; a owl:Class ; rdfs:label "urethra mesenchymal layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0015420 obo:IAO_0000115 "A valve that is part of a ureter." ; oboInOwl:hasDbXref "EMAPA:37781", "MA:0002658" ; oboInOwl:hasExactSynonym "ureteral valve", "valve or ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015420" ; a owl:Class ; rdfs:label "ureteral valve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0035809 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003978 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000056 ] ) ] . obo:UBERON_0015453 obo:IAO_0000115 "A lymph node that is part of a hypodermis." ; oboInOwl:hasDbXref "MA:0003028" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015453" ; a owl:Class ; rdfs:label "subcutaneous lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0015454 obo:IAO_0000115 "A fat pad that is part of a pancreas." ; oboInOwl:hasDbXref "MA:0003029" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015454" ; a owl:Class ; rdfs:label "pancreatic fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0015458 obo:IAO_0000115 "A fat pad that is part of a mediastinum." ; oboInOwl:hasDbXref "MA:0003063" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015458" ; a owl:Class ; rdfs:label "mediastinal fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003728 ] ) ] . obo:UBERON_0015474 obo:IAO_0000115 "A zone of skin that is part of a axilla." ; oboInOwl:hasDbXref "EMAPA:37349", "FMA:37322", "MA:0003087", "NCIT:C116164" ; oboInOwl:hasExactSynonym "axillary skin", "skin of axilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015474" ; a owl:Class ; rdfs:label "axilla skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] . obo:UBERON_0015476 obo:IAO_0000115 "A zone of skin that is part of a external nose." ; oboInOwl:hasDbXref "EMAPA:37684", "FMA:24763", "MA:0003090" ; oboInOwl:hasExactSynonym "external nasal skin", "skin of external nose", "skin of nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015476" ; a owl:Class ; rdfs:label "nose skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007827 ] ) ] . obo:UBERON_0015477 obo:IAO_0000115 "A fat pad that is part of a axilla." ; oboInOwl:hasDbXref "MA:0003091" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015477" ; a owl:Class ; rdfs:label "axillary fat pad" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] . obo:UBERON_0015479 obo:IAO_0000115 "A zone of skin that is part of a scrotum." ; oboInOwl:hasDbXref "EMAPA:36411", "FMA:20432", "MA:0003093", "SCTID:361710000" ; oboInOwl:hasExactSynonym "scrotal skin", "skin of scrotum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015479" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "scrotum skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ] ) ] . obo:UBERON_0015480 obo:IAO_0000115 "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." ; oboInOwl:hasDbXref "EMAPA:37217", "FMA:14772", "MA:0003095", "SCTID:244262006", "Wikipedia:Hepatic_artery_proper" ; oboInOwl:hasExactSynonym "hepatic artery proper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "proper hepatic" ; oboInOwl:id "UBERON:0015480" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "proper hepatic artery" ; rdfs:subClassOf obo:UBERON_0001193, _:genid158109 . obo:UBERON_0015481 obo:IAO_0000115 "A hepatic artery that is part of a left lobe of liver." ; oboInOwl:hasDbXref "EMAPA:37096", "FMA:14779", "MA:0003096" ; oboInOwl:hasExactSynonym "left branch of hepatic artery", "left part of hepatic artery proper", "ramus sinister (arteria hepatica propria)" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015481" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left hepatic artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0015480 ], _:genid158119 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001193 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001115 ] ) ] . obo:UBERON_0015482 obo:IAO_0000115 "A hepatic artery that is part of a right lobe of liver." ; oboInOwl:hasDbXref "EMAPA:37376", "FMA:14778", "MA:0003097" ; oboInOwl:hasExactSynonym "ramus dexter (arteria hepatica propria)", "right branch of hepatic artery proper", "right part of hepatic artery proper" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015482" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right hepatic artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0015480 ], _:genid158131 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001193 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001114 ] ) ] . obo:UBERON_0015485 obo:IAO_0000115 "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." ; oboInOwl:hasDbXref "EMAPA:37478", "MA:0003108" ; oboInOwl:hasExactSynonym "choledochoduodenal junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015485" ; a owl:Class ; rdfs:label "choledocho-duodenal junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002394 ] ) ] . obo:UBERON_0015593 obo:IAO_0000115 "A gyrus that is part of a frontal cortex." ; oboInOwl:hasDbXref "NCIT:C32636", "UMLS:C0228195" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015593" ; a owl:Class ; rdfs:label "frontal gyrus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000200 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001870 ] ) ] . obo:UBERON_0015716 obo:IAO_0000115 "An epithelium that is part of a anal canal." ; oboInOwl:hasDbXref "EMAPA:18835", "FMA:17511" ; oboInOwl:hasExactSynonym "anal canal epithelium", "epithelium of anal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015716" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "anal canal epithelium" ; rdfs:subClassOf obo:UBERON_0010371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] ) ] . obo:UBERON_0015717 obo:IAO_0000115 "A smooth muscle tissue that is part of a ejaculatory duct." ; oboInOwl:hasDbXref "EMAPA:32289", "FMA:19372" ; oboInOwl:hasExactSynonym "muscle layer of ejaculatory duct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015717" ; a owl:Class ; rdfs:label "smooth muscle tissue layer of ejaculatory duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000999 ] ) ] . obo:UBERON_0015751 obo:IAO_0000115 "A smooth muscle tissue that is part of a inferior eyelid tarsus." ; oboInOwl:hasDbXref "FMA:49059", "SCTID:368783000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015751" ; a owl:Class ; rdfs:label "inferior tarsal muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004774 ] ) ] . obo:UBERON_0015757 oboInOwl:hasDbXref "FMA:62798" ; oboInOwl:hasExactSynonym "portion of heterogeneous tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015757" ; a owl:Class ; rdfs:label "heterogeneous tissue" ; rdfs:subClassOf obo:UBERON_0000479 . obo:UBERON_0015766 obo:IAO_0000115 "An epithelium that is part of a duct of salivary gland." ; oboInOwl:hasDbXref "FMA:67682" ; oboInOwl:hasExactSynonym "epithelium of salivary duct", "salivary duct epithelium", "salivary ductal epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015766" ; a owl:Class ; rdfs:label "epithelium of duct of salivary gland" ; rdfs:subClassOf obo:UBERON_0010371 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001837 ] ) ] . obo:UBERON_0015783 obo:IAO_0000115 "A smooth muscle tissue that is part of a hypodermis." ; oboInOwl:hasDbXref "FMA:77862" ; oboInOwl:hasExactSynonym "muscle layer in fatty layer of subcutaneous tissue", "stratum musculosum panniculi adiposi telae subcutaneae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015783" ; a owl:Class ; rdfs:label "smooth muscle layer in fatty layer of subcutaneous tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002072 ] ) ] . obo:UBERON_0015787 obo:IAO_0000115 "Any anatomical conduit which is part of the upper respiratory tract." ; obo:UBPROP_0000001 "Anatomical cluster which consists a segment of the upper respiratory tract[FMA:265132]." ; oboInOwl:hasDbXref "FMA:265132" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "respiratory conduit" ; oboInOwl:id "UBERON:0015787" ; a owl:Class ; rdfs:label "upper respiratory conduit" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 ] ) ] . obo:UBERON_0015788 obo:IAO_0000115 "An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." ; oboInOwl:hasDbXref "FMA:265136" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015788" ; a owl:Class ; rdfs:label "olfactory apparatus chamber" ; rdfs:subClassOf obo:UBERON_0015787, _:genid155976 . obo:UBERON_0015789 obo:IAO_0000232 "see also, 'facial nerve muscle', which is not precisely equivalent. We include this grouping to accomodate the MA class, which includes masticatory muscle as a subtype; note the masticatory muscle is noy innervated by the facial nerve, unlike the facial muscles proper" ; oboInOwl:hasDbXref "EMAPA:25133", "MA:0000579" ; oboInOwl:hasExactSynonym "cranial/facial muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial-facial muscle", "cranio-facial muscle", "craniofacial muscle" ; oboInOwl:id "UBERON:0015789" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "cranial or facial muscle" ; rdfs:subClassOf obo:UBERON_0002376, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004473 ] . obo:UBERON_0015790 obo:IAO_0000115 "A zone of skin that is part of a autopod region." ; oboInOwl:hasDbXref "EMAPA:32723", "MA:0003120" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "paw skin" ; oboInOwl:id "UBERON:0015790" ; a owl:Class ; rdfs:label "autopod skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] ) ] . obo:UBERON_0015791 obo:IAO_0000115 "A portion of connective tissue that is part of a digit." ; oboInOwl:hasDbXref "EMAPA:37290", "MA:0003123" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015791" ; a owl:Class ; rdfs:label "digit connective tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0010702 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] ) ] . obo:UBERON_0015796 obo:IAO_0000115 "A blood vessel that is part of a liver." ; oboInOwl:hasDbXref "EMAPA:35498", "MA:0003137" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hepatic blood vessel" ; oboInOwl:id "UBERON:0015796" ; a owl:Class ; rdfs:label "liver blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0015807 obo:IAO_0000115 "An epithelium that is part of a ear." ; oboInOwl:hasDbXref "EMAPA:32800", "MA:0003161" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015807" ; a owl:Class ; rdfs:label "ear epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001690 ] ) ] . obo:UBERON_0015808 obo:IAO_0000115 "An epithelium that is part of a camera-type eye." ; oboInOwl:hasDbXref "EMAPA:35957", "MA:0003162" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015808" ; a owl:Class ; rdfs:label "eye epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ] ) ] . obo:UBERON_0015813 obo:IAO_0000115 "An epithelium that is part of a middle ear." ; oboInOwl:hasDbXref "EMAPA:35673", "MA:0003169" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015813" ; a owl:Class ; rdfs:label "middle ear epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] . obo:UBERON_0015814 obo:IAO_0000115 "An epithelium that is part of a external ear." ; oboInOwl:hasDbXref "EMAPA:35956", "MA:0003170" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015814" ; a owl:Class ; rdfs:label "outer ear epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_0015833 obo:IAO_0000115 "An epithelium that is part of a foregut." ; oboInOwl:hasDbXref "EMAPA:32922", "MA:0003204" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015833" ; a owl:Class ; rdfs:label "foregut epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 ] ) ] . obo:UBERON_0015834 obo:IAO_0000115 "A lamina propria that is part of a duodenum." ; oboInOwl:hasDbXref "EMAPA:27255", "FMA:15972", "MA:0003209" ; oboInOwl:hasExactSynonym "duodenal lamina propria", "lamina propria mucosae of duodenum", "lamina propria of duodenum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015834" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodenum lamina propria" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000320 ], _:genid158252 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000030 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0015837 obo:IAO_0000115 "A dental pulp that is part of a incisor tooth." ; obo:UBPROP_0000012 "FMA has classes for very specific sublcasses but no generic grouping at this level" ; oboInOwl:hasDbXref "EMAPA:35429", "FMA:294459", "MA:0003221" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015837" ; a owl:Class ; rdfs:label "incisor dental pulp" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0015838 obo:UBPROP_0000012 "FMA has classes for very specific sublcasses but no generic grouping at this level" ; oboInOwl:hasDbXref "EMAPA:35576", "FMA:294469", "MA:0003222" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015838" ; a owl:Class ; rdfs:label "molar dental pulp" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0015839 oboInOwl:hasDbXref "EMAPA:32878", "MA:0003224" ; oboInOwl:hasExactSynonym "epithelium of molar", "epithelium of molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015839" ; a owl:Class ; rdfs:label "molar epithelium" ; rdfs:subClassOf obo:UBERON_0003843 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0015842 obo:IAO_0000115 "A tooth enamel organ that is part of a incisor tooth." ; oboInOwl:hasDbXref "EMAPA:32895", "MA:0003227" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015842" ; a owl:Class ; rdfs:label "incisor enamel organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005176 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0015843 oboInOwl:hasDbXref "EMAPA:32880", "MA:0003228" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015843" ; a owl:Class ; rdfs:label "molar enamel organ" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015839 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005176 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0015844 oboInOwl:hasDbXref "EMAPA:32882", "MA:0003232" ; oboInOwl:hasExactSynonym "molar odontogenic papilla", "molar tooth odontogenic papilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015844" ; a owl:Class ; rdfs:label "molar dental papilla" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011641 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003655 ] ) ] . obo:UBERON_0015846 obo:IAO_0000115 "An odontogenic mesenchyme that is part of a incisor tooth." ; oboInOwl:hasDbXref "EMAPA:32894", "MA:0003229" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015846" ; a owl:Class ; rdfs:label "incisor mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0015847 obo:IAO_0000115 "A upper jaw incisor that is in_the_left_side_of a dentition." ; oboInOwl:hasDbXref "SCTID:245585000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015847" ; a owl:Class ; rdfs:label "upper left incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003450 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0003672 ] ) ] . obo:UBERON_0015848 obo:IAO_0000115 "An incisor tooth that protrudes beyond the mouth." ; obo:RO_0002175 obo:NCBITaxon_9780 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015848" ; a owl:Class ; rdfs:label "incisor tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] ) ] . obo:UBERON_0015849 obo:IAO_0000115 "An cuspid tooth that protrudes beyond the mouth." ; obo:RO_0002175 obo:NCBITaxon_41426, obo:NCBITaxon_9705, obo:NCBITaxon_9823 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015849" ; a owl:Class ; rdfs:label "canine tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003674 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] ) ] . obo:UBERON_0015850 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015850" ; a owl:Class ; rdfs:label "upper left incisor tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003450 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] ) ] . obo:UBERON_0015851 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015851" ; a owl:Class ; rdfs:label "upper right incisor tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003450 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] ) ] . obo:UBERON_0015852 obo:IAO_0000115 "A upper jaw incisor that protrudes prominently from the mouth as a single median tusk, found in narwhals." ; oboInOwl:hasExactSynonym "median incisor tusk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015852" ; a owl:Class ; rdfs:comment "Typically the left incisor with the right vestigial, but some males have two tusks" ; rdfs:label "narwhal tusk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003450 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000404 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001154 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001598 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002255 ] ) ] . obo:UBERON_0015853 obo:IAO_0000115 "A dental pulp that is part of a narwhal tusk." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015853" ; a owl:Class ; rdfs:label "dental pulp of median incisor tusk" ; rdfs:subClassOf _:genid158348 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001754 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015852 ] ) ] . obo:UBERON_0015854 obo:IAO_0000115 "An anatomical line that connects two successive vertebral pedicles. The length of this line is known as the interpedicular distance." ; oboInOwl:hasExactSynonym "inter-vertebral-pedicle line" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "interpedicular distance" ; oboInOwl:id "UBERON:0015854" ; a owl:Class ; rdfs:label "interpedicular line" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001078 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onClass obo:UBERON_0001078 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0015860 oboInOwl:hasDbXref "FMA:66178" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015860" ; a owl:Class ; rdfs:label "visceral abdominal lymph node" ; rdfs:subClassOf obo:UBERON_0002507 . obo:UBERON_0015870 obo:IAO_0000115 "A lymph node that is part of a head." ; oboInOwl:hasDbXref "FMA:61212", "SCTID:155136006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015870" ; a owl:Class ; rdfs:label "lymph node of head" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0015871 obo:IAO_0000115 "Any of the lymph nodes that are part of a face." ; obo:UBPROP_0000008 "In humans, these comprise three groups: (a) infraorbital or maxillary, scattered over the infraorbital region from the groove between the nose and cheek to the zygomatic arch; (b) buccinator, one or more placed on the Buccinator opposite the angle of the mouth; (c) supramandibular, on the outer surface of the mandible, in front of the Masseter and in contact with the external maxillary artery and anterior facial vein." ; oboInOwl:hasDbXref "FMA:61222", "SCTID:279139005", "Wikipedia:Facial_lymph_nodes" ; oboInOwl:hasExactSynonym "buccal lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015871" ; a owl:Class ; rdfs:label "facial lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] . obo:UBERON_0015873 obo:IAO_0000115 "A zone of skin that is part of a heel." ; oboInOwl:hasDbXref "EMAPA:37354", "MA:0003104", "SCTID:244185002" ; oboInOwl:hasExactSynonym "skin of heel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015873" ; a owl:Class ; rdfs:label "heel skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015875 ] ) ] . obo:UBERON_0015875 obo:IAO_0000115 "The part of the foot that is the projection of the calcaneus." ; oboInOwl:hasDbXref "FMA:24994", "MESH:D006365", "SCTID:362804005", "Wikipedia:Heel" ; oboInOwl:hasExactSynonym "calcaneal region", "heel region", "regio calcanea" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015875" ; a owl:Class ; rdfs:label "heel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004454 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005445 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001450 ] ) ] . obo:UBERON_0015917 obo:IAO_0000115 "A lymph node that is located close to the surface." ; oboInOwl:hasDbXref "FMA:12767", "NCIT:C102716" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015917" ; a owl:Class ; rdfs:label "superficial lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035549 ] ) ] . obo:UBERON_0015918 obo:IAO_0000115 "A lymph node that is located deeper within the organism, further from the surface." ; oboInOwl:hasDbXref "FMA:12768" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0015918" ; a owl:Class ; rdfs:label "deep lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] ) ] . obo:UBERON_0016398 obo:IAO_0000115 "A lymph node that is part of a hindlimb." ; oboInOwl:hasDbXref "FMA:44310", "SCTID:361109000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016398" ; a owl:Class ; rdfs:label "lymph node of lower limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 ] ) ] . obo:UBERON_0016399 obo:IAO_0000115 "A lymph node that is part of a forelimb." ; oboInOwl:hasDbXref "FMA:44311", "SCTID:276155004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016399" ; a owl:Class ; rdfs:label "lymph node of upper limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ] . obo:UBERON_0016400 obo:IAO_0000115 "The infrapatellar fat pad, also known as Hoffa's fat pad, is a cylindrical piece of fat that is situated under and behind the patella bone within the knee." ; oboInOwl:hasDbXref "FMA:58772", "SCTID:282128003", "Wikipedia:Infrapatellar_fat_pad" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016400" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "infrapatellar fat pad" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0013069 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) ] . obo:UBERON_0016404 obo:IAO_0000115 "A vertebral arch joint that is part of a cervical region of vertebral column." ; oboInOwl:hasDbXref "FMA:13668" ; oboInOwl:hasExactSynonym "cervical facet joint", "joint of cervical vertebral arch", "joint of cervical vertebral articular process", "zygapophyseal joint of cervical vertebrae", "zygapophysial joint of cervical vertebrae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016404" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "cervical vertebral arch joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001067 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006072 ] ) ] . obo:UBERON_0016405 obo:IAO_0000115 "A capillary that is part of a lung." ; oboInOwl:hasDbXref "FMA:14121" ; oboInOwl:hasExactSynonym "capillary of lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016405" ; oboInOwl:inSubset core:human_reference_atlas, core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary capillary" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0016408 obo:IAO_0000115 "The circumference of the base of the glans forms a rounded projecting border, the corona of the glans penis, overhanging a deep retroglandular sulcus, behind which is the neck of the penis." ; oboInOwl:hasDbXref "FMA:19627", "SCTID:362274002", "Wikipedia:Corona_of_glans_penis" ; oboInOwl:hasExactSynonym "corona of penis", "glans corona" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "corona glandis" ; oboInOwl:id "UBERON:0016408" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "corona of glans penis" ; rdfs:subClassOf obo:UBERON_0000064, _:genid158428 . obo:UBERON_0016409 oboInOwl:hasDbXref "FMA:19649" ; oboInOwl:hasExactSynonym "glans penile base" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016409" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "base of glans penis" ; rdfs:subClassOf obo:UBERON_0000064, _:genid158433 . obo:UBERON_0016410 obo:IAO_0000115 "A breast that is part of a male organism." ; oboInOwl:hasDbXref "FMA:19901", "NCIT:C33048", "UMLS:C0222604" ; oboInOwl:hasExactSynonym "mamma masculina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016410" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "male breast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000310 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ] . obo:UBERON_0016412 oboInOwl:hasDbXref "FMA:24003" ; oboInOwl:hasExactSynonym "central part of body of vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016412" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "central part of body of bony vertebral centrum" ; rdfs:subClassOf obo:UBERON_0005913, _:genid158442 . obo:UBERON_0016413 oboInOwl:hasDbXref "FMA:24023" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "central medullary cavity of long bone" ; oboInOwl:id "UBERON:0016413" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "medullary cavity of long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002484 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] . obo:UBERON_0016416 obo:IAO_0000115 "Subdivision of thorax which is anterior to the plane of the posterior boundary of the middle mediastinum." ; oboInOwl:hasDbXref "FMA:24816", "SCTID:182331006" ; oboInOwl:hasExactSynonym "anterior thoracic region", "front of chest", "ventral chest" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016416" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "anterior chest" ; rdfs:subClassOf obo:UBERON_0000475, _:genid158450 . obo:UBERON_0016418 obo:IAO_0000115 "The intersection of the frontal and two nasal bones of the human skull. Its manifestation on the visible surface of the face is a distinctly depressed area directly between the eyes, just superior to the bridge of the nose." ; oboInOwl:hasDbXref "FMA:264779", "Wikipedia:Nasion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016418" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "nasion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006983 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006813 ] ) ] . obo:UBERON_0016419 oboInOwl:hasDbXref "FMA:29741" ; oboInOwl:hasExactSynonym "bony part of arch of vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016419" ; a owl:Class ; rdfs:label "bony part of vertebral arch" ; rdfs:subClassOf obo:UBERON_0005913, _:genid158464 . obo:UBERON_0016422 obo:IAO_0000115 "A compact bone tissue that is part of a bone tissue of long bone." ; oboInOwl:hasDbXref "FMA:32674" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016422" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "compact bone of long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001439 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005808 ] ) ] . obo:UBERON_0016423 obo:IAO_0000115 "A compact bone tissue that is part of a diaphysis." ; oboInOwl:hasDbXref "FMA:32678" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016423" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "compact bone of diaphysis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001439 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004769 ] ) ] . obo:UBERON_0016425 obo:IAO_0000115 "An epiphyseal plate that is part of a radius bone." ; oboInOwl:hasDbXref "FMA:34354" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016425" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "epiphyseal plate of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002516 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001423 ] ) ] . obo:UBERON_0016426 oboInOwl:hasDbXref "FMA:35324" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016426" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "proximal interphalangeal joint of little finger" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009767 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003625 ] ) ] . obo:UBERON_0016430 obo:IAO_0000115 "The palmar branch of the median nerve is a branch of the median nerve which arises at the lower part of the forearm and innervates skin of proximal central palm and thenar eminence." ; obo:UBPROP_0000010 "does not pass through the carpal tunnel" ; oboInOwl:hasDbXref "FMA:44836", "Wikipedia:Palmar_branch_of_the_median_nerve" ; oboInOwl:hasExactSynonym "median nerve palmar branch", "palmar branch of anterior interosseous nerve", "palmar cutaneous branch of median nerve", "ramus palmaris (nervus medianus)", "ramus palmaris nervus interossei antebrachii anterior" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016430" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "palmar branch of median nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008878 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0017716 ], _:genid158489 . obo:UBERON_0016435 obo:IAO_0000115 "Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall." ; oboInOwl:hasDbXref "EMAPA:37233", "FMA:50060", "NCIT:C62484", "SCTID:181608004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016435" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chest wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001443 ] ) ] . obo:UBERON_0016440 obo:IAO_0000115 "A zone of the frontal bone that connects the supraorbital rirdges." ; oboInOwl:hasBroadSynonym "glabella" ; oboInOwl:hasDbXref "FMA:52851", "FMA:57136", "SCTID:137561005" ; oboInOwl:hasExactSynonym "glabellar surface of frontal bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016440" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "glabella region of bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000209 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0034766 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011576 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005913 [ a owl:Restriction ; owl:onClass obo:UBERON_0011576 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0016442 obo:IAO_0000115 "The line of junction between the horizontal parts of the palatine bones that extends from both sides of the skull to form the posterior part of the hard palate." ; oboInOwl:hasDbXref "FMA:52966" ; oboInOwl:hasExactSynonym "median palatine suture of skull", "middle palatine suture of skull", "midpalatal suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016442" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "median palatine suture" ; rdfs:subClassOf obo:UBERON_0035127 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035127 [ a owl:Restriction ; owl:onClass obo:UBERON_0001682 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0016446 obo:IAO_0000115 "A strand of hair that is part of a head." ; oboInOwl:hasDbXref "FMA:54241" ; oboInOwl:hasExactSynonym "head hair" ; oboInOwl:hasNarrowSynonym "hair of scalp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016446" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hair of head" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0016447 obo:IAO_0000115 "A strand of hair that is part of a trunk." ; oboInOwl:hasDbXref "FMA:54250" ; oboInOwl:hasExactSynonym "trunk hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016447" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hair of trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_0016452 oboInOwl:hasDbXref "FMA:55716" ; oboInOwl:hasExactSynonym "maxillary secondary premolar tooth", "upper permanent premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "permanent upper premolar tooth", "secondary upper premolar tooth" ; oboInOwl:id "UBERON:0016452" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper secondary premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017270 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0016453 oboInOwl:hasDbXref "FMA:55717" ; oboInOwl:hasExactSynonym "lower permanent premolar tooth", "mandibular secondary premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "permanent lower premolar tooth" ; oboInOwl:id "UBERON:0016453" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower secondary premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017270 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0016454 oboInOwl:hasDbXref "FMA:55722" ; oboInOwl:hasExactSynonym "maxillary central permanent incisor tooth", "maxillary central secondary incisor tooth", "upper central permanent incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "I1", "permanent upper central incisor tooth" ; oboInOwl:id "UBERON:0016454" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper central secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0016455 oboInOwl:hasDbXref "FMA:55724" ; oboInOwl:hasExactSynonym "maxillary lateral secondary incisor tooth", "upper lateral permanent incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "I2" ; oboInOwl:id "UBERON:0016455" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper lateral secondary incisor tooth" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/557"^^xsd:anyURI ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0016458 obo:IAO_0000115 "A hole in the diaphragm through which the esophagus passes." ; oboInOwl:hasDbXref "FMA:58289" ; oboInOwl:hasExactSynonym "esophageal hiatus of diaphragm", "oesophageal aperture", "oesophageal hiatus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016458" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "esophageal hiatus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0016459 obo:IAO_0000115 "The central point on the posterior surface of the lens." ; oboInOwl:hasDbXref "FMA:58898", "NCIT:C33375", "SCTID:302144008" ; oboInOwl:hasExactSynonym "polus posterior (lens)", "polus posterior lentis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016459" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "posterior pole of lens" ; rdfs:subClassOf obo:UBERON_0019210 . obo:UBERON_0016462 obo:IAO_0000115 "A zone of skin in the periorbital region of the face." ; oboInOwl:hasDbXref "EMAPA:37937", "FMA:59350" ; oboInOwl:hasExactSynonym "skin of orbital part of face" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016462" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "periorbital skin" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004090 ] ) ] . obo:UBERON_0016464 obo:IAO_0000115 "The midline prominence of the nose, extending from the nasal root to the tip." ; oboInOwl:hasDbXref "FMA:59517", "SCTID:368114008" ; oboInOwl:hasExactSynonym "nasal dorsum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nasal ridge" ; oboInOwl:id "UBERON:0016464" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "dorsum of nose" ; rdfs:subClassOf obo:UBERON_0000064, _:genid158592 . obo:UBERON_0016466 obo:IAO_0000115 "On the pinna, a curved prominence of cartilage, parallel with and in front of the helix, is called the antihelix, also known as the anthelix; this divides above into two crura, the crura antihelicis, between which is a triangular depression, the fossa triangularis." ; oboInOwl:hasDbXref "FMA:60995", "NCIT:C32120", "SCTID:279612003", "UMLS:C0229308", "Wikipedia:Antihelix" ; oboInOwl:hasExactSynonym "antihelical part of pinna", "antihelix (auricula)", "antihelix of pinna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anthelix" ; oboInOwl:id "UBERON:0016466" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "antihelix" ; rdfs:subClassOf obo:UBERON_0000481, _:genid158597, _:genid158599 . obo:UBERON_0016467 obo:IAO_0000115 "The antitragus is a feature of human ear anatomy. It is a small tubercle that points anteriorly. It is separated from the tragus by the intertragic notch." ; oboInOwl:hasDbXref "FMA:61001", "NCIT:C32121", "SCTID:362543000", "UMLS:C0229314", "Wikipedia:Antitragus" ; oboInOwl:hasExactSynonym "antitragal part of pinna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016467" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "antitragus" ; rdfs:subClassOf obo:UBERON_0000481, _:genid158606, _:genid158608 . obo:UBERON_0016475 obo:IAO_0000115 "A zone of skin that is part of a forehead." ; oboInOwl:hasDbXref "EMAPA:37952", "FMA:63883" ; oboInOwl:hasExactSynonym "forehead skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016475" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of forehead" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008200 ] ) ] . obo:UBERON_0016476 obo:IAO_0000115 "An incisor tooth that is part of a primary dentition." ; oboInOwl:hasDbXref "FMA:84200", "SCTID:51528000" ; oboInOwl:hasExactSynonym "deciduous incisor tooth", "temporary incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016476" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0016478 obo:IAO_0000115 "A stroma that is part of a liver." ; oboInOwl:hasDbXref "FMA:17553" ; oboInOwl:hasExactSynonym "hepatic stroma", "stroma of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016478" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "liver stroma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0016479 obo:IAO_0000115 "A collagenous capsule covering the external surface of the liver." ; obo:UBPROP_0000010 "It consists of type III collagen and extends to the stroma of endothelial sinusoids. It is covered by a single layer of mesothelial cells." ; oboInOwl:hasDbXref "FMA:15813", "SCTID:362185005", "Wikipedia:Fibrous_capsule_of_Glisson" ; oboInOwl:hasExactSynonym "capsula fibrosa perivascularis", "fibrous capsule of liver", "glisson's capsule", "hepatic capsule", "tunica fibrosa (hepar)", "tunica fibrosa hepatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fibrous capsule of Glisson", "liver capsule" ; oboInOwl:id "UBERON:0016479" ; a owl:Class ; rdfs:label "capsule of liver" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0018135 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_0016480 oboInOwl:hasDbXref "FMA:17525" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016480" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "interlobular stroma of liver" ; rdfs:subClassOf obo:UBERON_0016478, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004647 ] . obo:UBERON_0016481 obo:IAO_0000115 "A lymph node that is part of a bronchus." ; oboInOwl:hasDbXref "MA:0003078", "NCIT:C32232", "UMLS:C1305372" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016481" ; a owl:Class ; rdfs:label "bronchial lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) ] . obo:UBERON_0016490 obo:IAO_0000115 "Is the sensory system for the sense of hearing." ; obo:UBPROP_0000012 "Auditory system is general anatomical term in FMA" ; oboInOwl:hasDbXref "EMAPA:36002", "FMA:7192", "MA:0002443", "NCIT:C12889", "NLXANAT:090817", "UMLS:C0587901", "Wikipedia:Auditory_system", "neuronames:2888" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016490" ; a owl:Class ; rdfs:label "auditory system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002105 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001032 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007605 ] ) ] . obo:UBERON_0016491 obo:IAO_0000115 "Skeletal element that functionally replaces the notochord[VSAP,modified]." ; obo:UBPROP_0000001 "Skeletal element that surrounds the notochord.[VSAO]", "the main cylindrical portion of the vertebra ventral to the vertebral canal" ; obo:UBPROP_0000008 "The vertebral centrum may be cartilaginous, develop as cartilage but be replaced by bone or mineralized, or form directly through intramembranous ossification." ; oboInOwl:hasBroadSynonym "centrum" ; oboInOwl:hasDbXref "VSAO:0000183" ; oboInOwl:hasExactSynonym "centrum of vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016491" ; a owl:Class ; rdfs:label "vertebral centrum element" ; rdfs:subClassOf obo:UBERON_0004765, _:genid158663 . obo:UBERON_0016509 obo:IAO_0000115 "Luminal space of the right ventricle of the heart." ; oboInOwl:hasDbXref "EMAPA:26047", "FMA:9291" ; oboInOwl:hasExactSynonym "right ventricle lumen", "right ventricular cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016509" ; a owl:Class ; rdfs:label "cavity of right ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0016510 obo:IAO_0000115 "An epithelium that is part of a male urethra." ; oboInOwl:hasDbXref "EMAPA:30467", "FMA:19684" ; oboInOwl:hasExactSynonym "male urethral epithelium", "urethral epithelium of male" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016510" ; a owl:Class ; rdfs:label "epithelium of male urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 ] ) ] . obo:UBERON_0016512 obo:IAO_0000115 "An anatomical space that is part of a duodenum." ; oboInOwl:hasDbXref "EMAPA:19080", "FMA:14589" ; oboInOwl:hasExactSynonym "doudenal lumen", "duodenal lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016512" ; a owl:Class ; rdfs:label "lumen of duodenum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) ] . obo:UBERON_0016513 obo:IAO_0000115 "Luminal space of the left atrium of the heart." ; oboInOwl:hasDbXref "EMAPA:26011", "FMA:9465" ; oboInOwl:hasExactSynonym "left atrial cavity", "left atrium lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016513" ; a owl:Class ; rdfs:label "cavity of left atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002079 ] ) ] . obo:UBERON_0016514 obo:IAO_0000115 "Luminal space of the left ventricle of the heart." ; oboInOwl:hasDbXref "EMAPA:26038", "FMA:9466" ; oboInOwl:hasExactSynonym "left ventricular cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016514" ; a owl:Class ; rdfs:label "cavity of left ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0016517 obo:IAO_0000115 "An anatomical space that is part of a jejunum." ; oboInOwl:hasDbXref "EMAPA:18729", "FMA:14590" ; oboInOwl:hasExactSynonym "jejunal lumen", "jejunum lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016517" ; a owl:Class ; rdfs:label "lumen of jejunum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_0016520 obo:IAO_0000115 "An epithelium that is part of a female urethra." ; oboInOwl:hasDbXref "EMAPA:30470", "FMA:19774" ; oboInOwl:hasExactSynonym "female urethral epithelium", "urethral epithelium of female" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016520" ; a owl:Class ; rdfs:label "epithelium of female urethra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:UBERON_0016522 obo:IAO_0000115 "Luminal space of the right atrium of the heart." ; oboInOwl:hasDbXref "EMAPA:26020", "FMA:11359" ; oboInOwl:hasExactSynonym "right atrial cavity" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016522" ; a owl:Class ; rdfs:label "cavity of right atrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002078 ] ) ] . obo:UBERON_0016525 obo:IAO_0000115 "Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border." ; obo:IAO_0000116 "Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though" ; oboInOwl:hasBroadSynonym "frontal region", "regio frontalis" ; oboInOwl:hasDbXref "BAMS:Frontal_lobe", "BIRNLEX:928", "BM:Tel-Cx-FR", "CALOHA:TS-0389", "DHBA:12113", "EFO:0000913", "EV:0100167", "FMA:61824", "HBA:4009", "MAT:0000505", "MESH:D005625", "NCIT:C12352", "SCTID:180920004", "UMLS:C0016733", "UMLS:C1268977", "neuronames:56" ; oboInOwl:hasExactSynonym "lobi frontales", "lobus frontalis" ; oboInOwl:hasNarrowSynonym "frontal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016525" ; oboInOwl:inSubset core:efo_slim, core:human_reference_atlas ; a owl:Class ; rdfs:label "frontal lobe" ; rdfs:subClassOf obo:UBERON_0016526, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001871 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001872 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001893 ] . obo:UBERON_0016526 obo:IAO_0000115 "Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified]." ; obo:UBPROP_0000202 obo:FMA_77800 ; oboInOwl:hasAlternativeId "UBERON:0000322" ; oboInOwl:hasDbXref "BIRNLEX:922", "BTO:0000445", "FMA:61823", "SCTID:272632001", "neuronames:1210" ; oboInOwl:hasExactSynonym "cerebral hemisphere lobe", "cerebral lobe", "lobe of cerebral cortex", "lobe parts of cerebral cortex", "lobi cerebri" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cerebral cortical segment", "lobes of the brain", "regional organ part of cerebral cortex", "segment of cerebral cortex" ; oboInOwl:id "UBERON:0016526" ; a owl:Class ; rdfs:comment "We use the term lobe broadly as a rough regional area, encompassing homologous regions in smooth-brained mammals. We subdivide the lobes into white matter and neocortical parts." ; rdfs:label "lobe of cerebral hemisphere" ; rdfs:subClassOf obo:UBERON_0000064, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 ] . obo:UBERON_0016527 oboInOwl:hasDbXref "FMA:256176" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016527" ; a owl:Class ; rdfs:label "white matter of cerebral lobe" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0000107 ; owl:someValuesFrom obo:UBERON_0016529 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016526 ] ) ] . obo:UBERON_0016528 obo:IAO_0000115 "A white matter of cerebral lobe that is part of a frontal lobe." ; oboInOwl:hasDbXref "FMA:256178", "SCTID:362331002" ; oboInOwl:hasExactSynonym "frontal lobe white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016528" ; a owl:Class ; rdfs:label "white matter of frontal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016527 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016525 ] ) ] . obo:UBERON_0016529 obo:IAO_0000115 "Grey matter neocortex region of a lobe of the cerebral hemisphere." ; oboInOwl:hasDbXref "FMA:242197" ; oboInOwl:hasExactSynonym "cortex of cerebral hemisphere lobe", "cortex of lobe of cerebral hemisphere" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gray matter of lobe of cerebral hemisphere", "neocortical part of cerebral hemisphere" ; oboInOwl:id "UBERON:0016529" ; a owl:Class ; rdfs:label "cortex of cerebral lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005401 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016526 ] ) ] . obo:UBERON_0016530 obo:IAO_0000115 "Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border." ; oboInOwl:hasDbXref "DHBA:10208", "DMBA:16016", "EMAPA:35667", "FMA:242203", "MA:0000916", "NLX:79282", "SCTID:369217001", "neuronames:2473" ; oboInOwl:hasExactSynonym "cortex of parietal lobe", "parietal lobe cortex", "parietal neocortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gray matter of parietal lobe" ; oboInOwl:id "UBERON:0016530" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "parietal cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001872 ] ) ] . obo:UBERON_0016531 obo:IAO_0000115 "A white matter of cerebral lobe that is part of a parietal lobe." ; oboInOwl:hasDbXref "FMA:256184", "SCTID:369200008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016531" ; a owl:Class ; rdfs:label "white matter of parietal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016527 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001872 ] ) ] . obo:UBERON_0016534 obo:IAO_0000115 "A white matter of cerebral lobe that is part of a temporal lobe." ; oboInOwl:hasDbXref "FMA:256186", "SCTID:362344007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016534" ; a owl:Class ; rdfs:label "white matter of temporal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016527 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001871 ] ) ] . obo:UBERON_0016536 obo:IAO_0000115 "A white matter of cerebral lobe that is part of a limbic lobe." ; oboInOwl:hasDbXref "FMA:261091" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016536" ; a owl:Class ; rdfs:label "white matter of limbic lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016527 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002600 ] ) ] . obo:UBERON_0016538 obo:IAO_0000115 "Gray matter of the temporal region of the neocortex, located in the temporal lobe in gyrencephalic animals." ; oboInOwl:hasDbXref "BM:Tel-Cx-Te", "DHBA:10235", "DMBA:16044", "FMA:242201", "MA:0000941", "NLX:94939", "SCTID:362343001" ; oboInOwl:hasExactSynonym "cortex of temporal lobe", "temporal lobe cortex", "temporal neocortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gray matter of temporal lobe" ; oboInOwl:id "UBERON:0016538" ; a owl:Class ; rdfs:label "temporal cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001871 ] ) ] . obo:UBERON_0016542 oboInOwl:hasDbXref "FMA:242234" ; oboInOwl:hasExactSynonym "cortex of limbic lobe", "limbic lobe cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gray matter of limbic lobe" ; oboInOwl:id "UBERON:0016542" ; a owl:Class ; rdfs:label "limbic cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002600 ] ) ] . obo:UBERON_0016545 obo:IAO_0000115 "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." ; oboInOwl:hasAlternativeId "UBERON:2001379" ; oboInOwl:hasDbXref "TAO:0001379", "ZFA:0001379" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016545" ; a owl:Class ; rdfs:label "pharyngeal ectoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000490 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 ] ) ] . obo:UBERON_0016548 obo:IAO_0000115 "A layer of of the central nervous system that is part of gray matter." ; oboInOwl:hasBroadSynonym "grey matter layer" ; oboInOwl:hasDbXref "FMA:83142" ; oboInOwl:hasExactSynonym "CNS gray matter layer", "CNS grey matter layer", "gray matter layer of neuraxis", "grey matter layer of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016548" ; a owl:Class ; rdfs:label "central nervous system gray matter layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002020 ] ) ] . obo:UBERON_0016549 obo:IAO_0000115 "A layer of of the central nervous system that is composed of white matter." ; oboInOwl:hasBroadSynonym "white matter layer" ; oboInOwl:hasDbXref "FMA:83898" ; oboInOwl:hasExactSynonym "CNS white matter layer", "white matter layer of neuraxis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016549" ; a owl:Class ; rdfs:label "central nervous system white matter layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002316 ] ) ] . obo:UBERON_0016550 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016550" ; a owl:Class ; rdfs:label "spinal cord column" ; rdfs:subClassOf obo:UBERON_0005162, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] . obo:UBERON_0016551 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016551" ; oboInOwl:inSubset core:non_informative ; a owl:Class ; rdfs:label "subdivision of spinal cord ventral column" ; rdfs:subClassOf obo:UBERON_0016550, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005375 ] . obo:UBERON_0016552 obo:IAO_0000115 "Mucus produced in the respiratory tract." ; oboInOwl:hasDbXref "NCIT:C93171", "UMLS:C0225378" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016552" ; a owl:Class ; rdfs:label "phlegm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000912 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:UBERON_0016553 obo:IAO_0000115 "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016553" ; a owl:Class ; rdfs:label "respiratory system mucus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000912 _:genid156602 ) ] . obo:UBERON_0016554 obo:IAO_0000115 "A white matter that is part of the midbrain." ; oboInOwl:hasDbXref "DHBA:10650", "FMA:83936", "HBA:265505382" ; oboInOwl:hasExactSynonym "mesencephalic white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016554" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "white matter of midbrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0016565 obo:IAO_0000115 "A blood vessel that is part of a cerebellum." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016565" ; a owl:Class ; rdfs:label "cerebral blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008998 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0016566 obo:IAO_0000115 "An roughly circular indentation in a surface." ; oboInOwl:hasDbXref "AEO:0000204" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016566" ; oboInOwl:inSubset core:upper_level ; a owl:Class ; rdfs:label "pit" ; rdfs:subClassOf obo:UBERON_0036215 . obo:UBERON_0016570 oboInOwl:hasDbXref "FMA:68861", "Wikipedia:Rexed_laminae", "http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region" ; oboInOwl:hasExactSynonym "rexed lamina" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016570" ; a owl:Class ; rdfs:label "lamina of gray matter of spinal cord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0022303 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002315 ] ) ] . obo:UBERON_0016611 obo:IAO_0000115 "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016611" ; a owl:Class ; rdfs:label "auditory hillocks, pharyngeal arch 1 derived" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000477 _:genid156625 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ] ) ] . obo:UBERON_0016612 obo:IAO_0000115 "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016612" ; a owl:Class ; rdfs:label "auditory hillocks, pharyngeal arch 2 derived" ; owl:equivalentClass _:genid156630 . obo:UBERON_0016854 obo:IAO_0000115 "The dorsal region of the optic cup that gives rise to the dorsal part of the retina." ; oboInOwl:hasExactSynonym "dorsal optic cup", "dorsal region of optic cup" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016854" ; a owl:Class ; rdfs:label "dorsal part of optic cup" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0003072 ] ) ] . obo:UBERON_0016855 obo:IAO_0000115 "The ventral region of the optic cup that gives rise to the ventral part of the retina." ; oboInOwl:hasExactSynonym "ventral optic cup", "ventral region of optic cup" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016855" ; a owl:Class ; rdfs:comment "optic fissure, hyaloid artery, pecten" ; rdfs:label "ventral part of optic cup" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000481 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015102 ; owl:someValuesFrom obo:UBERON_0003072 ] ) ] . obo:UBERON_0016879 obo:IAO_0000115 "Primordium that develops into the central nervous system." ; oboInOwl:hasAlternativeId "UBERON:3000469" ; oboInOwl:hasExactSynonym "future CNS", "presumptive central nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016879" ; a owl:Class ; rdfs:label "future central nervous system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016880 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0016880 obo:IAO_0000115 "Primordium that develops into the nervous system." ; oboInOwl:hasAlternativeId "UBERON:3000477" ; oboInOwl:hasDbXref "AAO:0000477" ; oboInOwl:hasExactSynonym "presumptive nervous system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016880" ; a owl:Class ; rdfs:label "future nervous system" ; rdfs:subClassOf obo:UBERON_0006598, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002496 ; owl:someValuesFrom obo:UBERON_0000111 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0016884 obo:IAO_0000115 "The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints." ; oboInOwl:hasDbXref "MESH:D012785", "SCTID:361835002" ; oboInOwl:hasExactSynonym "joint of shoulder region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016884" ; a owl:Class ; rdfs:label "shoulder joint" ; rdfs:subClassOf _:genid158906 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 ] ) ] . obo:UBERON_0016885 obo:IAO_0000115 "Epithelium lining the distalmost portion of the digestive tract." ; oboInOwl:hasDbXref "BTO:0005445", "WBbt:0005800" ; oboInOwl:hasNarrowSynonym "rectum epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016885" ; a owl:Class ; rdfs:label "epithelium of terminal part of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006866 ] ) ] . obo:UBERON_0016886 obo:IAO_0000115 "Any muscle tissue of the distalmost portion of the digestive tract." ; oboInOwl:hasNarrowSynonym "rectum muscle", "rectum muscle structure" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016886" ; a owl:Class ; rdfs:label "muscle tissue of terminal part of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002385 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006866 ] ) ] . obo:UBERON_0016887 obo:IAO_0000115 "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." ; oboInOwl:hasDbXref "AEO:0000195", "EHDAA2:0000003", "EMAPA:16042" ; oboInOwl:hasExactSynonym "extra-embryonic component", "extraembryonic component" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016887" ; a owl:Class ; rdfs:label "entire extraembryonic component" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002050 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002491 ; owl:someValuesFrom obo:UBERON_0000068 ], _:genid158921 . obo:UBERON_0016888 obo:IAO_0000115 "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." ; oboInOwl:hasDbXref "AEO:0000132" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016888" ; a owl:Class ; rdfs:label "transitional anatomical structure" ; rdfs:subClassOf obo:UBERON_0005423 . obo:UBERON_0016896 obo:IAO_0000115 "A periosteum that is part of a long bone." ; oboInOwl:hasDbXref "FMA:32677" ; oboInOwl:hasExactSynonym "long bone periosteum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016896" ; a owl:Class ; rdfs:label "periosteum of long bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002515 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002495 ] ) ] . obo:UBERON_0016910 oboInOwl:hasDbXref "FMA:59820", "SCTID:264053009" ; oboInOwl:hasExactSynonym "frenulum labii", "labial frenulum", "lip frenulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial labial frenulum" ; oboInOwl:id "UBERON:0016910" ; a owl:Class ; rdfs:label "frenulum of lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003679 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0036294 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036293 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0016912 obo:IAO_0000115 "A frenulum of lip that is part of a upper lip." ; oboInOwl:hasDbXref "FMA:59821", "SCTID:264488001" ; oboInOwl:hasExactSynonym "f. labii superioris", "frenulum labii superioris", "upper lip frenulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016912" ; a owl:Class ; rdfs:label "frenulum of upper lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0005031 ], _:genid158947 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016910 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0016913 obo:IAO_0000115 "A frenulum of lip that is part of a lower lip." ; oboInOwl:hasDbXref "FMA:59822", "SCTID:277191003", "Wikipedia:Frenulum_of_lower_lip" ; oboInOwl:hasExactSynonym "frenulum labii inferioris", "lower lip frenulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "f. labii inferioris", "frenulum labii inferioris" ; oboInOwl:id "UBERON:0016913" ; a owl:Class ; rdfs:label "frenulum of lower lip" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0005032 ], _:genid158958 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016910 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] . obo:UBERON_0016915 obo:IAO_0000115 "The zone of the skin that surrounds a lip and is colored red due to thin epithelium and presence of eleidin." ; oboInOwl:hasBroadSynonym "vermilion border" ; oboInOwl:hasDbXref "FMA:59824", "SCTID:362086008" ; oboInOwl:hasExactSynonym "vermilion border of lip", "vermilion of lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vermillion" ; oboInOwl:id "UBERON:0016915" ; a owl:Class ; rdfs:label "vermilion" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000322 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0016918 obo:IAO_0000115 "A vermilion that is part of a upper lip." ; oboInOwl:hasDbXref "FMA:59827", "SCTID:245799004" ; oboInOwl:hasExactSynonym "vermilion border of upper lip", "vermilion of upper lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016918" ; a owl:Class ; rdfs:label "upper vermilion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0016919 obo:IAO_0000115 "A vermilion that is part of a lower lip." ; oboInOwl:hasDbXref "FMA:59828", "SCTID:245800000" ; oboInOwl:hasExactSynonym "vermilion border of lower lip", "vermilion of lower lip" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016919" ; a owl:Class ; rdfs:label "lower vermilion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016915 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] . obo:UBERON_0016928 obo:IAO_0000115 "A metaphysis that is part of a fibula." ; oboInOwl:hasDbXref "FMA:33745" ; oboInOwl:hasExactSynonym "fibula metaphysis", "fibular metaphysis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016928" ; a owl:Class ; rdfs:label "metaphysis of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0016943 oboInOwl:hasAlternativeId "UBERON:4200143" ; oboInOwl:hasBroadSynonym "LP" ; oboInOwl:hasExactSynonym "lower premolar tooth", "mandibular premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016943" ; a owl:Class ; rdfs:label "lower premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0016944 oboInOwl:hasAlternativeId "UBERON:4200144" ; oboInOwl:hasBroadSynonym "UP" ; oboInOwl:hasExactSynonym "maxillary premolar tooth", "upper premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0016944" ; a owl:Class ; rdfs:label "upper premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0017163 obo:IAO_0000115 "A bony structure embedded in skin, roughly equivalent to osteoderms." ; oboInOwl:hasBroadSynonym "bony tubercle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "bony tubercles" ; oboInOwl:id "UBERON:0017163" ; a owl:Class ; rdfs:label "skin bony tubercle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0017261 obo:IAO_0000115 "A sesamoid element that is part of a tarsal skeleton." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tarsal sesamoid" ; oboInOwl:id "UBERON:0017261" ; a owl:Class ; rdfs:label "intertarsal sesamoid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013631 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 ] ) ] . obo:UBERON_0017269 oboInOwl:hasDbXref "SCTID:421227007" ; oboInOwl:hasExactSynonym "deciduous premolar tooth", "primary premolar" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "primary bicuspid" ; oboInOwl:id "UBERON:0017269" ; a owl:Class ; rdfs:label "primary premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid156778 ] . obo:UBERON_0017270 oboInOwl:hasDbXref "SCTID:422038004" ; oboInOwl:hasExactSynonym "permanent premolar tooth", "secondary premolar" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "secondary bicuspid" ; oboInOwl:id "UBERON:0017270" ; a owl:Class ; rdfs:label "secondary premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0017271 oboInOwl:hasExactSynonym "maxillary primary premolar tooth", "upper deciduous premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017271" ; a owl:Class ; rdfs:label "upper primary premolar tooth" ; owl:equivalentClass _:genid156785 . obo:UBERON_0017272 oboInOwl:hasExactSynonym "lower deciduous premolar tooth", "mandibular primary premolar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017272" ; a owl:Class ; rdfs:label "lower primary premolar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0017615 obo:IAO_0000115 "A set of teeth in which each tooth that attaches to a vomer." ; oboInOwl:hasDbXref "AAO:0000635" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vomerine teeth" ; oboInOwl:id "UBERON:0017615" ; a owl:Class ; rdfs:label "vomerine dentition" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003672 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002396 ] ) ] . obo:UBERON_0017635 oboInOwl:hasDbXref "FMA:52568" ; oboInOwl:hasExactSynonym "paired dural venous sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017635" ; a owl:Class ; rdfs:label "paired venous dural sinus" ; owl:equivalentClass _:genid156802 . obo:UBERON_0017648 obo:IAO_0000115 "The ventral part of the body wall." ; oboInOwl:hasDbXref "EMAPA:37984", "FMA:86934" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior body wall" ; oboInOwl:id "UBERON:0017648" ; a owl:Class ; rdfs:label "ventral body wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013235 ] ) ] . obo:UBERON_0017649 obo:IAO_0000115 "The dorsal part of the body wall." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017649" ; a owl:Class ; rdfs:label "dorsal body wall" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000309 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ] ) ] . obo:UBERON_0017650 obo:IAO_0000115 "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." ; oboInOwl:hasDbXref "AEO:0001016" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017650" ; a owl:Class ; rdfs:label "developing mesenchymal structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0003104 ] ) ] . obo:UBERON_0017651 obo:IAO_0000115 "A primordium that has the potential to develop into a saliva-secreting gland." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017651" ; a owl:Class ; rdfs:label "salivary gland primordium" ; rdfs:subClassOf obo:UBERON_0005423, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0017654 obo:IAO_0000115 "Any of the small racemose mucous glands in the mucous membrane lining the cheeks." ; oboInOwl:hasDbXref "BTO:0005767", "SCTID:25421004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cheek gland" ; oboInOwl:id "UBERON:0017654" ; a owl:Class ; rdfs:label "buccal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ] ) ] . obo:UBERON_0017659 oboInOwl:hasDbXref "FMA:19624" ; oboInOwl:hasExactSynonym "urethral surface of penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017659" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "ventral surface of penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015102 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0017670 obo:IAO_0000115 "A bony part of vertebral arch that is part of a cervical vertebral arch." ; oboInOwl:hasDbXref "FMA:29794" ; oboInOwl:hasExactSynonym "bony part of arch of cervical vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017670" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bony part of cervical vertebral arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016419 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008434 ] ) ] . obo:UBERON_0017671 obo:IAO_0000115 "A bony part of vertebral arch that is part of a sacral vertebra 1." ; oboInOwl:hasDbXref "FMA:32395" ; oboInOwl:hasExactSynonym "bony part of vertebral arch of first sacral segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017671" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "bony part of vertebral arch of first sacral vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016419 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004622 ] ) ] . obo:UBERON_0017672 obo:IAO_0000115 "A viscus that is part of a abdomen." ; oboInOwl:hasDbXref "FMA:32413", "FMA:67355" ; oboInOwl:hasExactSynonym "abdominal viscera", "abdominal viscera set", "set of abdominal viscera" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017672" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "abdominal viscera" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ] . obo:UBERON_0017690 oboInOwl:hasDbXref "FMA:52856" ; oboInOwl:hasExactSynonym "facies interna (os frontale)", "facies interna ossis frontalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017690" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "internal surface of frontal bone" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000209 ] . obo:UBERON_0017692 obo:IAO_0000115 "Internal (endosteal) surface of the base of skull." ; oboInOwl:hasDbXref "FMA:53128" ; oboInOwl:hasExactSynonym "basis cranii interna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017692" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "internal surface of cranial base" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 ] . obo:UBERON_0017716 obo:IAO_0000115 "A raised fleshy area on the palm of the hand near the base of the thumb." ; oboInOwl:hasDbXref "FMA:61520", "SCTID:362748007", "Wikipedia:Thenar_eminence" ; oboInOwl:hasExactSynonym "thenar part of palm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017716" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "thenar eminence" ; rdfs:subClassOf obo:UBERON_0034929, _:genid159105 . obo:UBERON_0017717 obo:IAO_0000115 "Hypothenar refers to a group of three muscles of the palm that control the motion of the little finger. The three muscles are: Abductor digiti minimi Flexor digiti minimi Opponens digiti minimi." ; oboInOwl:hasDbXref "FMA:61523", "SCTID:362749004", "Wikipedia:Hypothenar_eminence" ; oboInOwl:hasExactSynonym "hypothenar part of palm" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017717" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "hypothenar eminence" ; rdfs:subClassOf obo:UBERON_0034929, _:genid159109 . obo:UBERON_0017732 obo:IAO_0000115 "A ridge of tissue that extends along the midline of the scrotum." ; obo:UBPROP_0000011 "The scrotal raphe is formed when the embryonic, urethral groove closes (week 12 in humans)" ; oboInOwl:hasDbXref "FMA:75130", "SCTID:279583006" ; oboInOwl:hasExactSynonym "scrotal raphe" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017732" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "raphe of scrotum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035106 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0006655 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013241 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0001300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002358 ] ) ] . obo:UBERON_0017748 obo:IAO_0000115 "A primary incisor tooth that is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:84215", "SCTID:420793009" ; oboInOwl:hasExactSynonym "lower deciduous incisor tooth", "primary lower incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deciduous lower incisor tooth" ; oboInOwl:id "UBERON:0017748" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0017750 obo:IAO_0000115 "A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton." ; obo:IAO_0000116 "awaiting approval by phenoscape curators" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017750" ; a owl:Class ; rdfs:label "proximal mesopodial endochondral element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009878 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010363 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006716 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0011584 ] ) ] . obo:UBERON_0017751 obo:IAO_0000115 "A proximal mesopodial endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0017751" ; a owl:Class ; rdfs:label "proximal mesopodial cartilage element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017750 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0018099 obo:IAO_0000115 "An endochondral element in the distal portion of the mesopodial skeleton, between the central mesopodial skeleton and the metapodial skeleton." ; obo:IAO_0000116 "TODO add logical definition" ; oboInOwl:hasExactSynonym "distal mesopodial" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018099" ; a owl:Class ; rdfs:label "distal mesopodial endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009878 ] . obo:UBERON_0018100 obo:IAO_0000115 "A distal mesopodial endochondral element that is composed primarily of cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018100" ; a owl:Class ; rdfs:label "distal mesopodial cartilage element" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0018101 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0018101 obo:IAO_0000115 "A distal mesopodial endochondral element that is composed primarily of a pre-cartilage condensation." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018101" ; a owl:Class ; rdfs:label "distal mesopodial pre-cartilage condensation" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0018102 obo:IAO_0000115 "A distal mesopodial endochondral element that is composed primarily of a bone tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018102" ; a owl:Class ; rdfs:label "distal mesopodial bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0018100 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018099 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) ] . obo:UBERON_0018111 obo:IAO_0000115 "A muscle layer that is part of the rectum." ; oboInOwl:hasDbXref "FMA:15035" ; oboInOwl:hasExactSynonym "muscular coat of rectum", "muscularis externa of rectum", "rectal muscularis propria", "tunica muscularis (rectum)", "tunica muscularis recti" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018111" ; a owl:Class ; rdfs:label "muscle layer of rectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0018112 obo:IAO_0000115 "Any portion of smooth muscle tissue that is part of the rectum." ; oboInOwl:hasExactSynonym "rectal smooth muscle tissue", "rectum smooth muscle", "smooth muscle of rectum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018112" ; a owl:Class ; rdfs:label "rectum smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0018113 obo:IAO_0000115 "A kidney interstitium that is part of a left kidney." ; oboInOwl:hasDbXref "FMA:74271" ; oboInOwl:hasExactSynonym "left renal stroma", "stroma of left kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018113" ; a owl:Class ; rdfs:label "left kidney interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004538 ] ) ] . obo:UBERON_0018114 obo:IAO_0000115 "A kidney interstitium that is part of a right kidney." ; oboInOwl:hasDbXref "FMA:74270" ; oboInOwl:hasExactSynonym "right renal stroma", "stroma of right kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018114" ; a owl:Class ; rdfs:label "right kidney interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004539 ] ) ] . obo:UBERON_0018115 obo:IAO_0000115 "A renal pelvis that is part of a left ureter." ; oboInOwl:hasDbXref "FMA:15579", "SCTID:243436005" ; oboInOwl:hasExactSynonym "pelvis of left ureter", "renal pelvis of left kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018115" ; a owl:Class ; rdfs:label "left renal pelvis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001224 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001223 ] ) ] . obo:UBERON_0018116 obo:IAO_0000115 "A renal pelvis that is part of a right ureter." ; oboInOwl:hasDbXref "FMA:15578", "SCTID:243419002" ; oboInOwl:hasExactSynonym "pelvis of right kidney", "pelvis of right ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018116" ; a owl:Class ; rdfs:label "right renal pelvis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001224 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001222 ] ) ] . obo:UBERON_0018117 obo:IAO_0000115 "A renal cortex interstitium that is part of a left kidney." ; oboInOwl:hasExactSynonym "cortical interstitial tissue of left kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018117" ; a owl:Class ; rdfs:label "left renal cortex interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005270 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004538 ] ) ] . obo:UBERON_0018118 obo:IAO_0000115 "A renal cortex interstitium that is part of a right kidney." ; oboInOwl:hasExactSynonym "cortical interstitial tissue of right kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018118" ; a owl:Class ; rdfs:label "right renal cortex interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005270 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004539 ] ) ] . obo:UBERON_0018119 obo:IAO_0000115 "A renal medulla interstitium that is part of a left kidney." ; oboInOwl:hasExactSynonym "medullary interstitial tissue of left kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018119" ; a owl:Class ; rdfs:label "left renal medulla interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004538 ] ) ] . obo:UBERON_0018120 obo:IAO_0000115 "A renal medulla interstitium that is part of a right kidney." ; oboInOwl:hasExactSynonym "medullary interstitial tissue of right kidney" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018120" ; a owl:Class ; rdfs:label "right renal medulla interstitium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004539 ] ) ] . obo:UBERON_0018132 obo:IAO_0000115 "Encapsulated adipose tissue that is part of a tail." ; obo:RO_0002175 obo:NCBITaxon_9258, obo:NCBITaxon_9305, obo:NCBITaxon_9935 ; obo:UBPROP_0000008 "The platypus uses its tail for storage of fat reserves (an adaptation also found in animals such as the Tasmanian devil and fat-tailed sheep)" ; oboInOwl:hasExactSynonym "tail fat depot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018132" ; a owl:Class ; rdfs:label "tail fat pad" ; rdfs:seeAlso obo:Tail_fat ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0018135 oboInOwl:hasDbXref "FMA:83521" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018135" ; a owl:Class ; rdfs:label "fibrocollagenous connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011824 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002462 ] ) ] . obo:UBERON_0018142 obo:IAO_0000115 "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx)." ; oboInOwl:hasAlternativeId "UBERON:0015006" ; oboInOwl:hasExactSynonym "caudal vertebra element", "tail vertebra element" ; oboInOwl:hasNarrowSynonym "coccygeal vertebra element", "coccyx vertebra element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018142" ; a owl:Class ; rdfs:label "caudal vertebra endochondral element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010913 _:genid157000 ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0001095 obo:UBERON_0013503 obo:UBERON_0013504 ) ] . obo:UBERON_0018143 obo:IAO_0000115 "A transverse process that is part of a cervical vertebra." ; obo:UBPROP_0000008 "May be homologous with the cervical ribs of some vertebrates" ; oboInOwl:hasDbXref "FMA:23894", "FMA:9913", "SCTID:280730000" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018143" ; a owl:Class ; rdfs:label "transverse process of cervical vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0018144 obo:IAO_0000115 "A rib that is attached to a cervical vertebra." ; obo:IAO_0000116 "Trunk, presacral and sacral ribs do not have a 'part of some region' asserted for them, we should add it to them[PHENOSCAPE:ad]" ; obo:UBPROP_0000008 "May be homologous with the transverse processes of cervical vertebra" ; oboInOwl:hasDbXref "EMAPA:37825", "MESH:D057070", "UBERONTEMP:d522e981-3a43-4cab-9862-4344b5c3ff22" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018144" ; a owl:Class ; rdfs:label "cervical rib" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005434 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002228 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002413 ] ) ] . obo:UBERON_0018145 obo:IAO_0000115 "A rib that is attached to a lumbar vertebra." ; obo:UBPROP_0000008 "May be homologous with the transverse processes of lumbar vertebra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018145" ; a owl:Class ; rdfs:label "lumbar rib" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002228 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] . obo:UBERON_0018146 obo:IAO_0000115 "A transverse process that is part of a lumbar vertebra." ; obo:UBPROP_0000008 "May be homologous with the lumbar ribs of some vertebrates" ; oboInOwl:hasDbXref "FMA:16080", "FMA:65469", "SCTID:280733003" ; oboInOwl:hasExactSynonym "costa lumbalis", "lumbar transverse process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018146" ; a owl:Class ; rdfs:label "transverse process of lumbar vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) ] . obo:UBERON_0018149 obo:IAO_0000115 "The lateral limit of each lateral part of the oral fissure." ; oboInOwl:hasDbXref "FMA:77269", "MFMO:0000145", "SCTID:263940002" ; oboInOwl:hasExactSynonym "angle of mouth", "mouth angle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018149" ; a owl:Class ; rdfs:comment "Serves as attachment site for zygomaticus major muscle." ; rdfs:label "angle of oral opening" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/1795" ; rdfs:subClassOf obo:UBERON_0010000, _:genid159271 . obo:UBERON_0018150 obo:IAO_0000115 "A zone of skin that is part of a lower lip." ; oboInOwl:hasDbXref "FMA:24767", "SCTID:281630002" ; oboInOwl:hasExactSynonym "lower lip skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018150" ; a owl:Class ; rdfs:label "skin of lower lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001835 ] ) ] . obo:UBERON_0018151 obo:IAO_0000115 "A zone of skin that is part of a upper lip." ; oboInOwl:hasDbXref "FMA:24765", "SCTID:281629007" ; oboInOwl:hasExactSynonym "upper lip skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018151" ; a owl:Class ; rdfs:label "skin of upper lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001834 ] ) ] . obo:UBERON_0018154 obo:IAO_0000115 "A ligament that is part of a middle ear." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018154" ; a owl:Class ; rdfs:label "ligament of middle ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ) ] . obo:UBERON_0018156 obo:IAO_0000115 "A skeletal ligament that attaches to the malleus." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018156" ; a owl:Class ; rdfs:label "malleal ligament" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001689 ] ) ] . obo:UBERON_0018226 obo:IAO_0000115 "An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels." ; oboInOwl:hasDbXref "FMA:67999" ; oboInOwl:hasExactSynonym "pulmonary lymphatic chain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pulmonary lymphatic vasculature" ; oboInOwl:id "UBERON:0018226" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pulmonary part of lymphatic system" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0018227 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011216 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006558 ] ) ] . obo:UBERON_0018227 obo:IAO_0000115 "A lymphatic vessel that is part of a lung." ; oboInOwl:hasDbXref "FMA:234006", "SCTID:321862009" ; oboInOwl:hasExactSynonym "lymphatic vessel of lung" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018227" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "pulmonary lymphatic vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0018226 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003529 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0018229 obo:IAO_0000115 "A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex." ; obo:IAO_0000232 "may be replaced by a GO process in future" ; oboInOwl:hasDbXref "FMA:74787", "MESH:D012084" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "renin angiotensin aldosterone system", "renin angiotensin system", "renin-angiotensin system", "renin-angiotensin-aldosterone system" ; oboInOwl:id "UBERON:0018229" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "renin-angiotensin system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0002016 ] . obo:UBERON_0018232 obo:IAO_0000115 "A sweat gland that is part of a axilla." ; oboInOwl:hasExactSynonym "axillary apocrine sweat gland", "sweat gland of axilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018232" ; a owl:Class ; rdfs:label "axillary sweat gland" ; rdfs:subClassOf obo:UBERON_0000382 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009472 ] ) ] . obo:UBERON_0018234 obo:IAO_0000115 "A stroma that is part of a pancreas." ; oboInOwl:hasDbXref "FMA:63121" ; oboInOwl:hasExactSynonym "pancreatic stroma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018234" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "stroma of pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0018235 obo:IAO_0000115 "A capsule that divides the parenchyma of the pancreas into lobes and lobules." ; obo:UBPROP_0000010 "typically thin but can thicken with age" ; oboInOwl:hasExactSynonym "pancreatic capsule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018235" ; a owl:Class ; rdfs:label "capsule of pancreas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0018239 obo:IAO_0000115 "A boundary delimiting a rhombomere." ; oboInOwl:hasExactSynonym "rhombomere junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018239" ; a owl:Class ; rdfs:label "rhombomere boundary" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007277 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001892 ] ) ] . obo:UBERON_0018243 obo:IAO_0000115 "A vein that supplies blood to the thymus." ; oboInOwl:hasDbXref "FMA:10647", "SCTID:76543001", "Wikipedia:Thymic_branches_of_internal_thoracic_artery" ; oboInOwl:hasExactSynonym "thymic branch of internal thoracic artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "thymic arteries" ; oboInOwl:id "UBERON:0018243" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:comment "The arteries supplying the thymus are derived from the internal thoracic artery, and from the superior thyroid artery and inferior thyroids.[WP]" ; rdfs:label "thymic artery" ; rdfs:subClassOf _:genid159351 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002370 ] ) ] . obo:UBERON_0018246 obo:IAO_0000115 "A vein that drains a thyroid gland." ; oboInOwl:hasDbXref "EMAPA:18648", "SCTID:303420005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018246" ; a owl:Class ; rdfs:label "thyroid vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0018247 obo:IAO_0000115 "An artery that supplies a cervical thymus." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018247" ; a owl:Class ; rdfs:label "cervical thymic artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0009114 ] ) ] . obo:UBERON_0018251 obo:IAO_0000115 "One of the veins draining a meninix." ; obo:UBPROP_0000008 "In humans, any of several veins that accompany the meningeal arteries, communicate with the sinuses of the dura mater and diploic veins, and drain into the regional veins outside the cranial vault." ; oboInOwl:hasDbXref "FMA:50839", "SCTID:84842006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018251" ; a owl:Class ; rdfs:label "meningeal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002360 ] ) ] . obo:UBERON_0018252 obo:IAO_0000115 "Accompanying vein of internal pudendal artery." ; obo:UBPROP_0000008 "In humans, they begin in the deep veins of the penis which issue from the corpus cavernosum penis, accompany the internal pudendal artery, and unite to form a single vessel, which ends in the internal iliac vein. They receive the veins from the urethral bulb, and the perineal and inferior hemorrhoidal veins" ; oboInOwl:hasDbXref "FMA:18917", "SCTID:14885008", "Wikipedia:Internal_pudendal_veins" ; oboInOwl:hasExactSynonym "vena pudenda interna" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "internal pudic vein" ; oboInOwl:id "UBERON:0018252" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "internal pudendal vein" ; rdfs:subClassOf obo:UBERON_0009029, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001317 ] . obo:UBERON_0018254 obo:IAO_0000116 "Added for consistency with MA EMAPA and EHDAA2. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/104" ; oboInOwl:hasDbXref "EHDAA2:0001842", "EMAPA:35578", "MA:0000165" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018254" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "skeletal musculature" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0014892 ], _:genid159375 . obo:UBERON_0018255 obo:IAO_0000115 "A branch of the superior mesenteric artery that supplies the jejunum." ; oboInOwl:hasDbXref "FMA:14808", "SCTID:265391008", "Wikipedia:Jejunal_arteries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "jejunal branch of superior mesenteric artery" ; oboInOwl:id "UBERON:0018255" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "jejunal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001182 ] ) ] . obo:UBERON_0018256 obo:IAO_0000115 "A vein that drains a lacrimal gland." ; oboInOwl:hasDbXref "FMA:51779", "SCTID:149582008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018256" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lacrimal vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0011192 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001817 ] ) ] . obo:UBERON_0018257 obo:IAO_0000115 "Any portion of submucosa that lines the digestive tract." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018257" ; a owl:Class ; rdfs:label "submucosa of digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0018260 obo:IAO_0000115 "Any organ component layer that consists of muscle tissue." ; obo:UBPROP_0000012 "NCITA class may refer to smooth muscle only" ; oboInOwl:hasDbXref "FMA:45634", "NCIT:C75444", "UMLS:C0225358" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018260" ; a owl:Class ; rdfs:label "layer of muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002385 ] ) ] . obo:UBERON_0018261 obo:IAO_0000115 "A muscular coat that is part of a digestive tract." ; obo:UBPROP_0000009 "responsible for gut movement, such as peristalsis" ; oboInOwl:hasExactSynonym "tunica muscularis of digestive tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "muscular layer of digestive tract", "muscularis externa of digestive tract", "tunica externa of digestive tract" ; oboInOwl:id "UBERON:0018261" ; a owl:Class ; rdfs:label "muscular coat of digestive tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0030432 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0018265 obo:IAO_0000115 "The anterior or rostral end of the zygomatic arch, which includes the temporal process of the zygomatic bone, but also including some of the body of the zygomatic bone. It may also include the zygomatico-temporal suture and the most rostral portion of the zygomatic process of the temporal bone." ; obo:IAO_0000116 "requires definition see https://github.com/obophenotype/uberon/issues/492" ; oboInOwl:hasDbXref "MFMO:0000109" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018265" ; a owl:Class ; rdfs:label "anterior root of zygomatic arch" ; rdfs:subClassOf obo:UBERON_0005913, _:genid159409 . obo:UBERON_0018299 obo:IAO_0000115 "Tooth of the lower jaw that is adjacent to the mandibular symphysis." ; oboInOwl:hasBroadSynonym "symphyseal tooth" ; oboInOwl:hasDbXref "UBERONTEMP:2f99ad4b-d842-4ae9-8886-87ee98811fe5" ; oboInOwl:hasExactSynonym "lower jaw symphyseal tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018299" ; a owl:Class ; rdfs:label "mandibular symphyseal tooth" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006606 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004768 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0018542 ] ) ] . obo:UBERON_0018302 obo:IAO_0000115 "First molar (counting anteroposteriorly) in the upper jaw." ; oboInOwl:hasDbXref "UBERONTEMP:12acbe6c-9036-48e3-b1a0-1f2fdaa0241d" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018302" ; a owl:Class ; rdfs:label "upper molar 1" ; rdfs:subClassOf obo:UBERON_0003666 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018303 obo:IAO_0000115 "Tissue that is part of some adrenal gland." ; obo:IAO_0000116 "TODO - describe typology of adrenal gland tissue used in this ontology" ; oboInOwl:hasDbXref "NCIT:C32051", "UBERONTEMP:a7bf197b-0db2-467e-824e-be45b39e2672" ; oboInOwl:hasExactSynonym "adrenal gland tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018303" ; a owl:Class ; rdfs:label "adrenal tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ] . obo:UBERON_0018321 obo:IAO_0000115 "Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX)." ; oboInOwl:hasDbXref "UBERONTEMP:9ca0bda7-9111-4f59-bc72-5d47bc3d7d61" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018321" ; a owl:Class ; rdfs:label "foramen for glossopharyngeal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003128 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001649 ] ) ] . obo:UBERON_0018326 obo:IAO_0000115 "Situated just caudal to the acetabulum, the foramen is bound dorsally by the illium and ventrally by the ischium. The foramen transmitts the ischiadic nerves and vessels (Baumel et al. 1993)." ; oboInOwl:hasDbXref "UBERONTEMP:63e09c69-ac98-49ba-b232-2da5c7b19019" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018326" ; a owl:Class ; rdfs:label "ilioischiadic foramen" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001273 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001274 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005744 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001322 ] ) ] . obo:UBERON_0018376 obo:IAO_0000115 "The molar tooth of the upper or lower jaw that is phylogenetically number 1." ; oboInOwl:hasDbXref "FMA:321614", "SCTID:422372003" ; oboInOwl:hasExactSynonym "first molar tooth", "molar 1", "molar 1 tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018376" ; a owl:Class ; rdfs:label "molar tooth 1" ; rdfs:subClassOf obo:UBERON_0003655 . obo:UBERON_0018405 oboInOwl:hasDbXref "FMA:53243", "SCTID:280261005" ; oboInOwl:hasExactSynonym "inferior dental nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018405" ; a owl:Class ; rdfs:label "inferior alveolar nerve" ; rdfs:subClassOf obo:UBERON_0001021, _:genid159445 . obo:UBERON_0018406 obo:IAO_0000115 "Mental nerve is a general somatic afferent (sensory) nerve which provides sensation to the anterior aspects of the chin and lower lip as well as the buccal gingivae of the mandibular anterior teeth and the premolars. It is a branch of the posterior trunk of the inferior alveolar nerve, which is itself a branch of the mandibular division of the trigeminal nerve (CN V). The nerve emerges at the mental foramen in the mandibula, and divides beneath the Depressor anguli oris muscle into three branches: one descends to the skin of the chin. two ascend to the skin and mucous membrane of the lower lip. These branches communicate freely with the facial nerve." ; oboInOwl:hasDbXref "FMA:53250", "SCTID:280138001", "Wikipedia:Mental_nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018406" ; a owl:Class ; rdfs:label "mental nerve" ; rdfs:subClassOf obo:UBERON_0001027, _:genid159452 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008199 ] ) ] . obo:UBERON_0018408 obo:IAO_0000115 "A branch of the maxillary nerve that enters the infraorbital canal and innervates the lower eyelid, upper lip, the nasal vestibule, the upper incisors, canines, premolars, upper gums, lower eyelid and conjunctiva, and part of the nose." ; oboInOwl:hasDbXref "FMA:52978", "SCTID:280360008", "Wikipedia:Infraorbital_nerve" ; oboInOwl:hasExactSynonym "infraorbital nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "infra-orbital nerve", "infraorbital portion" ; oboInOwl:id "UBERON:0018408" ; a owl:Class ; rdfs:label "infra-orbital nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000402 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001834 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0011601 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000377 ] ) ] . obo:UBERON_0018411 obo:IAO_0000115 "A skeletal ligament that is part of a hip joint." ; oboInOwl:hasDbXref "FMA:42868", "SCTID:182435001" ; oboInOwl:hasExactSynonym "hip joint ligament" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018411" ; a owl:Class ; rdfs:label "ligament of hip joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001486 ] ) ] . obo:UBERON_0018413 obo:IAO_0000115 "A Z-shaped canal running through the temporal bone from the internal acoustic meatus to the stylomastoid foramen. It is located within the middle ear region, according to its shape it is divided into three main segments: the labyrinthine, the tympanic, and the mastoidal segment ." ; oboInOwl:hasDbXref "FMA:54952", "Wikipedia:Facial_canal" ; oboInOwl:hasExactSynonym "canalis nervi facialis", "facial canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "fallopian canal" ; oboInOwl:id "UBERON:0018413" ; a owl:Class ; rdfs:label "facial nerve canal" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001647 ] ) ] . obo:UBERON_0018415 obo:IAO_0000115 "An bone foramen in the ethmoid bone." ; obo:UBPROP_0000008 "There are usually two Foramina ethmoidalia present on each side in the dog. Sometimes one is situated rostral to the other, but often it is dorsal. They are not homologous with the Foramen ethmoidale anterius and Foramen ethmoidale posterius of man. Therefore they are not listed separately.[NOMINA ANATOMICA VETERINARIA (2005)]" ; oboInOwl:hasDbXref "Wikipedia:Ethmoidal_foramina" ; oboInOwl:hasExactSynonym "ethmoidal foramen", "foramina ethmoidalia" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ethmoid foramina", "ethmoidal foramina" ; oboInOwl:id "UBERON:0018415" ; a owl:Class ; rdfs:comment "Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina" ; rdfs:label "ethmoid foramen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001679 ] ) ] . obo:UBERON_0018508 obo:IAO_0000115 "A vascular foramen opening on the outer surface of a nasal bone." ; oboInOwl:hasDbXref "FMA:57653", "Wikipedia:Nasal_foramina" ; oboInOwl:hasExactSynonym "foramina nasalia", "nasal foramen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "foramen of nasal bone", "nasal foramina" ; oboInOwl:id "UBERON:0018508" ; a owl:Class ; rdfs:label "foramen of nasal bone" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001981 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001681 ] ) ] . obo:UBERON_0018529 obo:IAO_0000115 "An inguinal ring that is part of a female reproductive system." ; oboInOwl:hasDbXref "EMAPA:19172", "MA:0003250" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018529" ; a owl:Class ; rdfs:label "female inguinal ring" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004353 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0018530 obo:IAO_0000115 "An inguinal ring that is part of a male reproductive system." ; oboInOwl:hasDbXref "EMAPA:29307" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018530" ; a owl:Class ; rdfs:label "male inguinal ring" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004354 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0018531 obo:IAO_0000115 "A deep inguinal ring that is part of a female reproductive system." ; oboInOwl:hasDbXref "EMAPA:19174", "MA:0003252" ; oboInOwl:hasExactSynonym "female external inguinal ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018531" ; a owl:Class ; rdfs:label "female superficial inguinal ring" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ] . obo:UBERON_0018532 obo:IAO_0000115 "A deep inguinal ring that is part of a male reproductive system." ; oboInOwl:hasDbXref "EMAPA:19173", "MA:0003251" ; oboInOwl:hasExactSynonym "female internal inguinal ring" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018532" ; a owl:Class ; rdfs:label "female deep inguinal ring" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079 ] ) ] . obo:UBERON_0018542 obo:IAO_0000115 "The region of the mandible on or near the midline (near the mandiblular symphysis)." ; oboInOwl:hasBroadSynonym "symphyseal region" ; oboInOwl:hasDbXref "MFMO:0000147" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018542" ; a owl:Class ; rdfs:label "mandibular symphyseal region" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004742 ] . obo:UBERON_0018543 obo:IAO_0000115 "The anatomical space within the intestine." ; obo:IAO_0000116 "see notes in inclusivity in class 'intestine'" ; oboInOwl:hasDbXref "FMA:14586", "TADS:0000495", "WBbt:0005791", "ZFA:0005807" ; oboInOwl:hasExactSynonym "intestinal lumen", "intestine lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gut lumen" ; oboInOwl:id "UBERON:0018543" ; a owl:Class ; rdfs:label "lumen of intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000160 ] ) ] . obo:UBERON_0018544 obo:IAO_0000115 "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." ; oboInOwl:hasDbXref "MFMO:0000072" ; oboInOwl:hasExactSynonym "muscle innervated by the trigeminal nerve", "muscles innervated by the trigeminal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018544" ; a owl:Class ; rdfs:label "trigeminal nerve muscle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004362 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001645 ] ) ] . obo:UBERON_0018550 oboInOwl:hasDbXref "FMA:84201", "SCTID:304571003" ; oboInOwl:hasExactSynonym "permanent incisor", "permanent incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018550" ; a owl:Class ; rdfs:label "secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018551 oboInOwl:hasDbXref "SCTID:422364000" ; oboInOwl:hasExactSynonym "central incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018551" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "central incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018552 oboInOwl:hasDbXref "SCTID:422366003" ; oboInOwl:hasExactSynonym "lateral incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018552" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lateral incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018553 oboInOwl:hasExactSynonym "primary central incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018553" ; a owl:Class ; rdfs:label "primary central incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016476 [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018554 oboInOwl:hasExactSynonym "primary lateral incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018554" ; a owl:Class ; rdfs:label "primary lateral incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016476 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018561 obo:IAO_0000115 "A secondary canine tooth that is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:55714" ; oboInOwl:hasExactSynonym "maxillary secondary canine tooth", "upper permanent canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "C", "permanent upper canine tooth" ; oboInOwl:id "UBERON:0018561" ; a owl:Class ; rdfs:label "upper secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018562 obo:IAO_0000115 "A secondary canine tooth that is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:55715" ; oboInOwl:hasExactSynonym "lower permanent canine tooth", "mandibular secondary canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "c", "permanent lower canine tooth" ; oboInOwl:id "UBERON:0018562" ; a owl:Class ; rdfs:label "lower secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018584 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018568 obo:IAO_0000115 "A lower jaw incisor that is in_the_central_side_of a dentition." ; oboInOwl:hasDbXref "FMA:55723" ; oboInOwl:hasExactSynonym "lower central permanent incisor tooth", "mandibular central permanent incisor", "mandibular central secondary incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "i1" ; oboInOwl:id "UBERON:0018568" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower central secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003451 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018570 obo:IAO_0000115 "A lower jaw incisor that is in_the_lateral_side_of a dentition." ; oboInOwl:hasDbXref "FMA:55725" ; oboInOwl:hasExactSynonym "lower lateral permanent incisor tooth", "mandibular lateral permanent incisor", "mandibular lateral secondary incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "i2" ; oboInOwl:id "UBERON:0018570" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower lateral secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003451 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018575 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:55811" ; oboInOwl:hasExactSynonym "maxillary first secondary molar tooth", "upper first permanent molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "M1" ; oboInOwl:id "UBERON:0018575" ; a owl:Class ; rdfs:label "upper first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018576 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:55812" ; oboInOwl:hasExactSynonym "maxillary second secondary molar tooth", "upper second permanent tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "M2" ; oboInOwl:id "UBERON:0018576" ; a owl:Class ; rdfs:label "upper second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018578 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:55814" ; oboInOwl:hasExactSynonym "lower first permanent molar tooth", "mandibular first secondary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "m1" ; oboInOwl:id "UBERON:0018578" ; a owl:Class ; rdfs:label "lower first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018579 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:55815" ; oboInOwl:hasExactSynonym "lower second permanent molar tooth", "lower secondary molar 2", "mandibular second secondary molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "m2" ; oboInOwl:id "UBERON:0018579" ; a owl:Class ; rdfs:label "lower second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018583 oboInOwl:hasDbXref "FMA:84202", "SCTID:15819002" ; oboInOwl:hasExactSynonym "deciduous canine tooth", "primary tooth C", "temporary canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018583" ; a owl:Class ; rdfs:label "primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018584 oboInOwl:hasDbXref "FMA:84203", "SCTID:134340007" ; oboInOwl:hasExactSynonym "permanent canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018584" ; a owl:Class ; rdfs:label "secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018588 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:84211" ; oboInOwl:hasExactSynonym "upper first deciduous molar tooth", "upper primary tooth D" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dM1" ; oboInOwl:id "UBERON:0018588" ; a owl:Class ; rdfs:label "upper first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018589 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:84212" ; oboInOwl:hasExactSynonym "lower first deciduous molar tooth", "lower primary molar 1", "lower primary tooth D" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dm1" ; oboInOwl:id "UBERON:0018589" ; a owl:Class ; rdfs:label "lower first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018591 obo:IAO_0000115 "A primary incisor tooth that is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:84214" ; oboInOwl:hasExactSynonym "upper deciduous incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deciduous upper incisor tooth" ; oboInOwl:id "UBERON:0018591" ; a owl:Class ; rdfs:label "upper primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016476 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018593 obo:IAO_0000115 "A upper primary canine tooth that is in_the_central_side_of a dentition." ; oboInOwl:hasDbXref "FMA:84216" ; oboInOwl:hasExactSynonym "upper central deciduous incisor tooth", "upper primary tooth A" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dI1" ; oboInOwl:id "UBERON:0018593" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018591 [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018594 obo:IAO_0000115 "A upper primary canine tooth that is in_the_lateral_side_of a dentition." ; oboInOwl:hasDbXref "FMA:84217" ; oboInOwl:hasExactSynonym "upper lateral deciduous incisor tooth", "upper primary tooth B" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dI2" ; oboInOwl:id "UBERON:0018594" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018591 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018595 obo:IAO_0000115 "A lower primary incisor tooth that is in_the_central_side_of a dentition." ; oboInOwl:hasDbXref "FMA:84218" ; oboInOwl:hasExactSynonym "lower central deciduous incisor tooth", "lower primary tooth A" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deciduous lower central incisor tooth", "di1" ; oboInOwl:id "UBERON:0018595" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017748 [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018596 obo:IAO_0000115 "A lower primary incisor tooth that is in_the_lateral_side_of a dentition." ; oboInOwl:hasDbXref "FMA:84219" ; oboInOwl:hasExactSynonym "lower lateral deciduous incisor tooth", "lower primary tooth B", "mandibular lateral primary incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deciduous lower lateral incisor tooth", "di2" ; oboInOwl:id "UBERON:0018596" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0017748 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018597 obo:IAO_0000115 "A primary canine tooth that is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:84228", "SCTID:421810006" ; oboInOwl:hasExactSynonym "upper deciduous canine tooth", "upper primary tooth C" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dC", "deciduous upper canine tooth" ; oboInOwl:id "UBERON:0018597" ; a owl:Class ; rdfs:label "upper primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018583 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018598 obo:IAO_0000115 "A primary canine tooth that is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:84229", "SCTID:420326009" ; oboInOwl:hasExactSynonym "lower deciduous canine tooth", "lower primary tooth C", "primary lower canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dc", "deciduous lower canine tooth" ; oboInOwl:id "UBERON:0018598" ; a owl:Class ; rdfs:label "lower primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018583 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018599 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:84236" ; oboInOwl:hasExactSynonym "upper primary tooth E", "upper second deciduous molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dM2" ; oboInOwl:id "UBERON:0018599" ; a owl:Class ; rdfs:label "upper second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018600 obo:IAO_0000116 "TODO - tooth numbering nomeculature to be aligned across species" ; oboInOwl:hasDbXref "FMA:84237" ; oboInOwl:hasExactSynonym "lower primary tooth E", "lower second deciduous molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dm2" ; oboInOwl:id "UBERON:0018600" ; a owl:Class ; rdfs:label "lower second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018601 obo:IAO_0000115 "An incisor tooth that is in_the_central_side_of a dentition and is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:290182" ; oboInOwl:hasExactSynonym "lower central incisor", "mandibular central incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018601" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower central incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018602 obo:IAO_0000115 "An incisor tooth that is in_the_lateral_side_of a dentition and is part of a lower jaw region." ; oboInOwl:hasDbXref "FMA:290197" ; oboInOwl:hasExactSynonym "lower lateral incisor", "mandibular lateral incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018602" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower lateral incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018603 obo:IAO_0000115 "An incisor tooth that is in_the_central_side_of a dentition and is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:290180" ; oboInOwl:hasExactSynonym "maxillary central incisor", "upper central incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018603" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper central incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0020001 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018604 obo:IAO_0000115 "An incisor tooth that is in_the_lateral_side_of a dentition and is part of a upper jaw region." ; oboInOwl:hasDbXref "FMA:290194" ; oboInOwl:hasExactSynonym "maxillary lateral incisor", "upper lateral incisor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018604" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper lateral incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0018645 ] ) ] . obo:UBERON_0018606 obo:IAO_0000115 "The molar tooth of the upper or lower jaw that is phylogenetically number 2." ; oboInOwl:hasDbXref "FMA:321613", "SCTID:422374002" ; oboInOwl:hasExactSynonym "molar 2", "molar 2 tooth", "second molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018606" ; a owl:Class ; rdfs:label "molar tooth 2" ; rdfs:subClassOf obo:UBERON_0003655 . obo:UBERON_0018607 oboInOwl:hasDbXref "SCTID:420479003" ; oboInOwl:hasExactSynonym "permanent second molar tooth", "second permanent molar", "second permanent molar tooth", "secondary second molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018607" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "permanent molar tooth 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018608 oboInOwl:hasDbXref "SCTID:304565009" ; oboInOwl:hasExactSynonym "first permanent molar", "first permanent molar tooth", "permanent first molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018608" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "permanent molar tooth 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0018613 oboInOwl:hasDbXref "SCTID:245564000" ; oboInOwl:hasExactSynonym "permanent upper tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018613" ; a owl:Class ; rdfs:label "secondary upper tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018614 oboInOwl:hasDbXref "SCTID:245588003" ; oboInOwl:hasExactSynonym "secondary lower tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018614" ; a owl:Class ; rdfs:label "permanent lower tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007775 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018616 oboInOwl:hasDbXref "SCTID:245613009" ; oboInOwl:hasExactSynonym "deciduous upper tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018616" ; a owl:Class ; rdfs:label "primary upper tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018617 oboInOwl:hasDbXref "SCTID:245628009" ; oboInOwl:hasExactSynonym "deciduous lower tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018617" ; a owl:Class ; rdfs:label "primary lower tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018621 oboInOwl:hasExactSynonym "maxillary canine tooth", "upper canine", "upper cuspid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018621" ; a owl:Class ; rdfs:label "upper canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0018622 oboInOwl:hasExactSynonym "lower canine", "lower cuspid", "mandibular canine tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018622" ; a owl:Class ; rdfs:label "lower canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003674 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018623 oboInOwl:hasDbXref "FMA:55713" ; oboInOwl:hasExactSynonym "lower permanent incisor tooth", "mandibular secondary incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "permanent lower incisor tooth" ; oboInOwl:id "UBERON:0018623" ; a owl:Class ; rdfs:label "lower secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018550 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0018643 oboInOwl:hasDbXref "SCTID:422595006" ; oboInOwl:hasExactSynonym "deciduous second molar tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018643" ; a owl:Class ; rdfs:label "deciduous molar tooth 2" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018606 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018644 oboInOwl:hasDbXref "SCTID:423890001" ; oboInOwl:hasExactSynonym "deciduous first molar tooth", "deciduous molar 1", "first temporarary molar" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018644" ; a owl:Class ; rdfs:label "deciduous molar tooth 1" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018376 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ] . obo:UBERON_0018645 obo:IAO_0000115 "The subdivision of the dentition that consists entire of incisor teeth." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "set of incisors" ; oboInOwl:id "UBERON:0018645" ; a owl:Class ; rdfs:label "incisor region of dentition" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003672 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001098 ] ) ] . obo:UBERON_0018649 oboInOwl:hasDbXref "FMA:83450" ; oboInOwl:hasExactSynonym "ventricular cardiac muscle tissue", "ventricular heart muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ventricular muscle" ; oboInOwl:id "UBERON:0018649" ; a owl:Class ; rdfs:label "cardiac muscle tissue of ventricle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001083 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001133 _:genid157585 ) ] . obo:UBERON_0018664 obo:IAO_0000115 "The neck region of a bone organ." ; oboInOwl:hasExactSynonym "bone neck", "neck of bone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018664" ; a owl:Class ; rdfs:label "neck of bone element" ; rdfs:subClassOf obo:UBERON_0005913 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_0018667 oboInOwl:hasDbXref "FMA:23254", "SCTID:181915009" ; oboInOwl:hasExactSynonym "anatomical neck of scapula", "collum scapulae", "scapular neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018667" ; a owl:Class ; rdfs:label "neck of scapula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] . obo:UBERON_0018673 oboInOwl:hasDbXref "EMAPA:37891", "FMA:35508" ; oboInOwl:hasExactSynonym "fibula neck", "fibular neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018673" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "neck of fibula" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001446 ] ) ] . obo:UBERON_0018674 obo:IAO_0000115 "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." ; oboInOwl:hasDbXref "FMA:73747", "ZFA:0005811" ; oboInOwl:hasExactSynonym "cardiac vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018674" ; a owl:Class ; rdfs:label "heart vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0018679 obo:IAO_0000115 "Thoracic splanchnic nerves are splanchnic nerves that arise from the sympathetic trunk in the thorax and travel inferiorly to provide sympathetic innervation to the abdomen. The nerves contain preganglionic sympathetic and general visceral afferent fibers." ; oboInOwl:hasDbXref "FMA:6280", "Wikipedia:Thoracic_splanchnic_nerves" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018679" ; a owl:Class ; rdfs:label "thoracic splanchnic nerve" ; rdfs:subClassOf _:genid159865 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003715 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004863 ] ) ] . obo:UBERON_0018691 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018691" ; a owl:Class ; rdfs:label "ventral side of post-anal tail" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013235 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015102 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0018692 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018692" ; a owl:Class ; rdfs:label "dorsal side of post-anal tail" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0018707 obo:IAO_0000115 "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." ; oboInOwl:hasDbXref "BTO:0000123" ; oboInOwl:hasNarrowSynonym "bladder" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0018707" ; a owl:Class ; rdfs:label "bladder organ" ; rdfs:subClassOf obo:UBERON_0000489, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001987 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000463 ] . obo:UBERON_0019042 oboInOwl:hasDbXref "BTO:0002439" ; oboInOwl:hasExactSynonym "genital mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019042" ; a owl:Class ; rdfs:label "reproductive system mucosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 ] ) ] . obo:UBERON_0019143 obo:IAO_0000115 "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." ; oboInOwl:hasDbXref "BTO:0004043" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intramuscular fat" ; oboInOwl:id "UBERON:0019143" ; a owl:Class ; rdfs:label "intramuscular adipose tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014892 ] ) ] . obo:UBERON_0019189 oboInOwl:hasDbXref "BTO:0004626" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carotid endothelium", "carotid epithelium" ; oboInOwl:id "UBERON:0019189" ; a owl:Class ; rdfs:label "carotid artery endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005396 ] ) ] . obo:UBERON_0019190 oboInOwl:hasDbXref "BTO:0004638", "FMA:13119", "SCTID:88410004" ; oboInOwl:hasExactSynonym "bronchial gland", "bronchial mucous gland", "peribronchial gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019190" ; a owl:Class ; rdfs:label "mucous gland of lung" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000414 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0019196 oboInOwl:hasDbXref "BTO:0004661" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019196" ; a owl:Class ; rdfs:label "iliac artery endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005609 ] ) ] . obo:UBERON_0019197 obo:IAO_0000115 "The deep terminal division of the pudendal nerve that runs along the dorsum of the penis and innervates the the corpus cavernosum penis, the prepuce and the glans penis." ; oboInOwl:hasDbXref "FMA:21869", "SCTID:306800005", "Wikipedia:Dorsal_nerve_of_the_penis" ; oboInOwl:hasExactSynonym "nervus dorsalis penis", "nervus dorsalis penis " ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal nerve of penis", "dorsal nerves of the penis" ; oboInOwl:id "UBERON:0019197" ; a owl:Class ; rdfs:label "dorsal nerve of penis" ; rdfs:subClassOf _:genid159924 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001299 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001332 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0011390 ] ) ] . obo:UBERON_0019198 obo:IAO_0000115 "The deep terminal division of the pudendal nerve that runs along the dorsum of the clitoral shaft and innervates the the glans clitoris." ; oboInOwl:hasDbXref "FMA:21870", "SCTID:367687005", "Wikipedia:Dorsal_nerve_of_clitoris" ; oboInOwl:hasExactSynonym "nervus dorsalis clitoridis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dorsal nerve of the clitoris" ; oboInOwl:id "UBERON:0019198" ; a owl:Class ; rdfs:label "dorsal nerve of clitoris" ; rdfs:subClassOf _:genid159939 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002411 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0006653 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0011390 ] ) ] . obo:UBERON_0019200 obo:IAO_0000115 "Zone of skin that is part of the anterior region of the chest." ; oboInOwl:hasDbXref "FMA:10461" ; oboInOwl:hasExactSynonym "anterior chest skin", "skin of anterior part of thorax", "skin of ventral chest", "ventral chest skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019200" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "skin of anterior chest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016416 ] ) ] . obo:UBERON_0019204 obo:IAO_0000115 "Any region of epithelium that is part of a skin region." ; oboInOwl:hasDbXref "BTO:0004382" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019204" ; a owl:Class ; rdfs:label "skin epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000014 ] ) ] . obo:UBERON_0019206 oboInOwl:hasDbXref "EMAPA:35869", "MA:0003178" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019206" ; a owl:Class ; rdfs:label "tongue papilla epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001726 ] ) ] . obo:UBERON_0019207 obo:IAO_0000115 "The part of the eye that consists of both the retina and the optic choroid." ; oboInOwl:hasDbXref "SCTID:110701000" ; oboInOwl:hasExactSynonym "chorioretina", "choroid and retina", "retinachoroid", "retinachoroidal region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019207" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "chorioretinal region" ; rdfs:subClassOf obo:UBERON_0000481, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000966 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001776 ] . obo:UBERON_0019210 obo:IAO_0000115 "A central point or region on the anterior or posterior surface of the lens." ; oboInOwl:hasDbXref "FMA:58067", "SCTID:280630009" ; oboInOwl:hasExactSynonym "lens pole", "lens zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "zone of lens" ; oboInOwl:id "UBERON:0019210" ; a owl:Class ; rdfs:label "pole of lens" ; rdfs:subClassOf obo:UBERON_0034944, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000965 ] . obo:UBERON_0019221 obo:IAO_0000115 "Either of the outermost digits in a five-digit autopod, or their phylogenetic equivalent." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral digit", "outer digit", "outermost digit" ; oboInOwl:id "UBERON:0019221" ; a owl:Class ; rdfs:label "digit 1 or 5" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0002544 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006048 obo:UBERON_0006052 ) ] . obo:UBERON_0019222 obo:IAO_0000115 "Any of the three medial digits in a five-digit autopod, or their phylogenetic equivalent." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial digit", "mesoaxial digit" ; oboInOwl:id "UBERON:0019222" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "digit 2, 3 or 4" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0002544 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006049 obo:UBERON_0006050 obo:UBERON_0006051 ) ] . obo:UBERON_0019231 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral finger", "lateral manual digit", "outer manual digit", "outermost manual digit" ; oboInOwl:id "UBERON:0019231" ; a owl:Class ; rdfs:label "manual digit 1 or 5" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0019221, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001463 obo:UBERON_0003625 ) ] . obo:UBERON_0019232 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial manual digit", "mesoaxial manual digit", "mesoxaxial finger" ; oboInOwl:id "UBERON:0019232" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "manual digit 2, 3 or 4" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0019222, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0003622 obo:UBERON_0003623 obo:UBERON_0003624 ) ] . obo:UBERON_0019241 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral pedal digit", "lateral toe", "outer pedal digit", "outermost pedal digit" ; oboInOwl:id "UBERON:0019241" ; a owl:Class ; rdfs:label "pedal digit 1 or 5" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0019221, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0003631 obo:UBERON_0003635 ) ] . obo:UBERON_0019242 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "medial pedal digit", "mesoaxial pedal digit", "mesoxaxial ftoe" ; oboInOwl:id "UBERON:0019242" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "pedal digit 2, 3 or 4" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/592"^^xsd:anyURI ; rdfs:subClassOf obo:UBERON_0019222, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0003632 obo:UBERON_0003633 obo:UBERON_0003634 ) ] . obo:UBERON_0019243 oboInOwl:hasDbXref "SCTID:280385004" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin groove" ; oboInOwl:id "UBERON:0019243" ; a owl:Class ; rdfs:label "skin crease" ; rdfs:subClassOf obo:UBERON_0003102, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000014 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002255 ] . obo:UBERON_0019246 oboInOwl:hasDbXref "SCTID:244159001" ; oboInOwl:hasExactSynonym "skin crease of palmar part of manus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019246" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "palmar skin crease" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0019243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008878 ] ) ] . obo:UBERON_0019247 oboInOwl:hasDbXref "SCTID:244192007" ; oboInOwl:hasExactSynonym "skin crease of plantar part of pes" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019247" ; a owl:Class ; rdfs:label "plantar skin crease" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0019243 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008338 ] ) ] . obo:UBERON_0019253 oboInOwl:hasDbXref "FMA:55712" ; oboInOwl:hasExactSynonym "maxillary secondary incisor tooth", "upper permanent incisor", "upper permanent incisor tooth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019253" ; a owl:Class ; rdfs:label "upper secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001098 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007774 ] ) ] . obo:UBERON_0019254 oboInOwl:hasDbXref "FMA:59408" ; oboInOwl:hasExactSynonym "eyelash of upper eyelid", "upper eyelid cilium", "upper eyelid eyelash" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hair of upper eyelid", "upper eyelid cilia" ; oboInOwl:id "UBERON:0019254" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "upper eyelash" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001702 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0019255 oboInOwl:hasDbXref "FMA:59409" ; oboInOwl:hasExactSynonym "eyelash of lower eyelid", "lower eyelid cilium", "lower eyelid eyelash" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "hair of lower eyelid", "lower eyelid cilia" ; oboInOwl:id "UBERON:0019255" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "lower eyelash" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001702 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0019258 obo:IAO_0000115 "A white matter that is part of the hindbrain." ; oboInOwl:hasDbXref "DHBA:10668", "FMA:268636" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019258" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "white matter of hindbrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0019261 obo:IAO_0000115 "A white matter that is part of the forebrain." ; oboInOwl:hasDbXref "DHBA:10557", "FMA:268634" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019261" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "white matter of forebrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0019262 obo:IAO_0000115 "A white matter that is part of the myelencephalon." ; oboInOwl:hasDbXref "HBA:9298" ; oboInOwl:hasExactSynonym "myelencephalic white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019262" ; a owl:Class ; rdfs:label "white matter of myelencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005290 ] ) ] . obo:UBERON_0019263 oboInOwl:hasDbXref "DHBA:10654", "FMA:268630" ; oboInOwl:hasExactSynonym "gray matter of the hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019263" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "gray matter of hindbrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0019264 oboInOwl:hasDbXref "DHBA:10157", "FMA:268608" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019264" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "gray matter of forebrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 ] ) ] . obo:UBERON_0019267 oboInOwl:hasDbXref "DHBA:10649", "FMA:83913" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019267" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "gray matter of midbrain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ] . obo:UBERON_0019269 oboInOwl:hasDbXref "FMA:83912" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019269" ; a owl:Class ; rdfs:label "gray matter of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0019291 oboInOwl:hasDbXref "FMA:83939", "HBA:9287" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019291" ; a owl:Class ; rdfs:label "white matter of metencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001895 ] ) ] . obo:UBERON_0019292 oboInOwl:hasDbXref "FMA:83940" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019292" ; a owl:Class ; rdfs:label "white matter of pons" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 _:genid157839 ) ] . obo:UBERON_0019293 oboInOwl:hasAlternativeId "UBERON:0025819" ; oboInOwl:hasDbXref "BIRNLEX:1069", "FMA:83942", "HBA:265505486" ; oboInOwl:hasExactSynonym "pontine white matter tracts", "predominantly white regional part of pontine tegmentum", "substantia alba tegmenti pontis", "white matter of pontile tegmentum", "white substance of pontile tegmentum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019293" ; a owl:Class ; rdfs:label "white matter of pontine tegmentum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 ] ) ] . obo:UBERON_0019294 oboInOwl:hasDbXref "HBA:9220" ; oboInOwl:hasExactSynonym "telencephalic commissures" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019294" ; a owl:Class ; rdfs:label "commissure of telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ] . obo:UBERON_0019304 oboInOwl:hasDbXref "EMAPA:35952", "MA:0003174" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019304" ; a owl:Class ; rdfs:label "sensory organ epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000020 ] ) ] . obo:UBERON_0019306 oboInOwl:hasDbXref "EMAPA:35958", "MA:0003171" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019306" ; a owl:Class ; rdfs:label "nose epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 ] ) ] . obo:UBERON_0019307 obo:IAO_0000115 "Epithelial layer that is part of the external part of the nose." ; oboInOwl:hasDbXref "FMA:63143" ; oboInOwl:hasExactSynonym "epithelium of skin of external nose" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019307" ; a owl:Class ; rdfs:label "epithelium of external nose" ; rdfs:subClassOf obo:UBERON_0012329 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007827 ] ) ] . obo:UBERON_0019315 obo:IAO_0000115 "An oily substance that prevents evaporation of the eye's tear film." ; obo:UBPROP_0000009 "provides barrier to prevent dessication of cornea[ISBN:0123813611]" ; obo:UBPROP_0000015 "part of surface lipid layer of tear film" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "tarsal gland secretion" ; oboInOwl:id "UBERON:0019315" ; a owl:Class ; rdfs:label "meibum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0010230 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0022287 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001866 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001818 ] ) ] . obo:UBERON_0019319 obo:IAO_0000115 "An exocrine gland that is part of a integumental system." ; oboInOwl:hasExactSynonym "integumental exocrine gland", "integumental system exocrine gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0019319" ; a owl:Class ; rdfs:label "exocrine gland of integumental system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] ) ] . obo:UBERON_0020358 obo:IAO_0000115 "The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals." ; oboInOwl:hasDbXref "EMAPA:37067", "FMA:83965", "MA:0001033", "Wikipedia:Spinal_accessory_nucleus", "neuronames:2003" ; oboInOwl:hasExactSynonym "accessory neural nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "accessory nucleus of anterior column of spinal cord", "nucleus accessorius columnae anterioris medullae spinalis", "nucleus nervi accessorii", "nucleus of accessory nerve", "nucleus of the accessory nerve", "nucleus of the spinal accessory nerve", "spinal accessory nucleus" ; oboInOwl:id "UBERON:0020358" ; a owl:Class ; rdfs:comment "See also: Wikipedia:Spinal_accessory_nucleus" ; rdfs:label "accessory XI nerve nucleus" ; rdfs:subClassOf obo:UBERON_0000126, obo:UBERON_0006331, _:genid160136 . obo:UBERON_0020550 obo:IAO_0000115 "A blood vessel that supplies or drains an ear." ; oboInOwl:hasDbXref "EMAPA:37386", "MA:0001226" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0020550" ; a owl:Class ; rdfs:label "auricular blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001690 ] ) ] . obo:UBERON_0022235 oboInOwl:hasDbXref "FMA:62444" ; oboInOwl:hasExactSynonym "diencephalon peduncle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022235" ; a owl:Class ; rdfs:label "peduncle of diencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007417 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ] . obo:UBERON_0022236 oboInOwl:hasDbXref "MBA:365", "neuronames:1982" ; oboInOwl:hasExactSynonym "thalamic peduncle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022236" ; a owl:Class ; rdfs:label "peduncle of thalamus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007417 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001897 ] ) ] . obo:UBERON_0022248 oboInOwl:hasDbXref "FMA:260712" ; oboInOwl:hasExactSynonym "cerebral fascicle", "cerebral fasciculus", "nerve fascicle of telencephalon", "telencephalic fascicle", "telencephalic nerve fascicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022248" ; a owl:Class ; rdfs:label "cerebral nerve fasciculus" ; owl:equivalentClass _:genid157913 . obo:UBERON_0022278 obo:IAO_0000115 "A nucleus in the ventral part of the anterior horn of the sacral region of the spinal cord that is the origin of the pudendal nerve." ; obo:UBPROP_0000009 "involved in the maintenance of micturition and defecatory continence, as well as muscular contraction during orgasm." ; obo:UBPROP_0000010 "The neurons in Onuf's nucleus are motoneurons, and like most motoneurons they are characterized by their mulipolarity and large Nissl bodies" ; oboInOwl:hasDbXref "FMA:257031", "FMA:77024", "Wikipedia:Onuf%27s_nucleus", "neuronames:2701" ; oboInOwl:hasExactSynonym "Onuf's nucleus", "nucleus of Onuf", "pudendal neural nucleus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022278" ; a owl:Class ; rdfs:label "nucleus of pudendal nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002257 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005853 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000125 _:genid157921 ) ] . obo:UBERON_0022279 oboInOwl:hasDbXref "FMA:53671" ; oboInOwl:hasExactSynonym "hair of external ear", "hair of tragus", "tragus hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022279" ; a owl:Class ; rdfs:label "strand of hair on external ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_0022284 obo:IAO_0000115 "The single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland)." ; obo:UBPROP_0000008 "in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; between E15.5 and E16.5 the bud undergoes branching morphogenesis, forming both a major extra-orbital lobe and a minor intraorbital lobe" ; oboInOwl:hasDbXref "EMAPA:35464" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022284" ; a owl:Class ; rdfs:label "lacrimal gland bud" ; rdfs:subClassOf obo:UBERON_0005153, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001750 ] . obo:UBERON_0022287 obo:IAO_0000115 "An aqueous substance that covers the anterior surface of the eyeball, keeping the cornea wet." ; obo:UBPROP_0000001 "the thin acellular fluid layer that adheres to the most superficial layer of the corneal epithelium and lubricates and protects the ocular surface; the film is generally composed of three layers: (i) an inner mucous layer, secreted largely by the conjunctival goblet cells with contributions from the lacrimal glands, which coats the cornea, provides a hydrophobic layer, and allows for even distribution of the tear film; (ii) a middle aqueous layer, secreted by the lacrimal glands, which keeps the corneal surface moist, and provides a mechanism for oxygenation and nutrient exchange with the avascular anterior corneal tissue; and (iii) an outer lipid layer, secreted principally by the Meibomian (tarsal) glands although lipid tear elements also are contributed by the Harderian glands; tear film lipids form a monolayer on the tear surface, and function by enhancing the surface tension which supports the integrity of the tear film against collapse due to gravity and also slows down the loss of the tear film by evaporation; in addition , the lipid layer provides a glassy, smooth interface between the air and the transparent cornea" ; obo:UBPROP_0000009 "maintenance of the avascular transparent corneal epithelium" ; obo:UBPROP_0000010 "The tear film is structurally complex with three distinct layers: a surface lipid layer, a middle aqueous layer, and an inner mucus layer[http://physiologyonline.physiology.org/content/13/2/97]" ; oboInOwl:hasExactSynonym "precorneal film" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022287" ; a owl:Class ; rdfs:label "tear film" ; rdfs:subClassOf obo:UBERON_0000456, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010409 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001735 ], [ a owl:Restriction ; owl:onProperty core:protects ; owl:someValuesFrom obo:UBERON_0010409 ], _:genid160191 . obo:UBERON_0022288 oboInOwl:hasDbXref "FMA:58315" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "surface of region of wall of eyeball" ; oboInOwl:id "UBERON:0022288" ; a owl:Class ; rdfs:label "surface of eyeball" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0010230 ] ) ] . obo:UBERON_0022292 oboInOwl:hasDbXref "NCIT:C33596", "SCTID:282511007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022292" ; a owl:Class ; rdfs:label "splenic arteriole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0022293 obo:IAO_0000115 "A portion of organism substance that is secreted by a reproductive gland." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "genital fluid", "genital secretion", "reproductive system fluid", "reproductive system fluid/secretion", "reproductive system secretion" ; oboInOwl:id "UBERON:0022293" ; a owl:Class ; rdfs:label "reproductive gland secretion" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0003937 ] ) ] . obo:UBERON_0022296 obo:IAO_0000115 "A nerve that innervates a lower eyelid and is a branch of the infra-orbital branch of the maxillary nerve." ; oboInOwl:hasDbXref "FMA:52983", "Wikipedia:Inferior_palpebral_nerve" ; oboInOwl:hasExactSynonym "rami palpebrales inferiores nervi infraorbitalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022296" ; a owl:Class ; rdfs:label "inferior palpebral branch of infra-orbital nerve" ; owl:equivalentClass _:genid160211 . obo:UBERON_0022297 obo:IAO_0000115 "A nerve that innervates an eyelid and is a branch of the infra-orbital branch of the maxillary nerve." ; oboInOwl:hasDbXref "SCTID:280236007" ; oboInOwl:hasExactSynonym "palpebral branch of maxillary nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022297" ; a owl:Class ; rdfs:label "palpebral branch of infra-orbital nerve" ; owl:equivalentClass _:genid160220 . obo:UBERON_0022298 obo:IAO_0000115 "A nerve that innervates a lower eyelid." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022298" ; a owl:Class ; rdfs:label "lower eyelid nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001713 ] ) ] . obo:UBERON_0022299 obo:IAO_0000115 "A nerve that innervates an upper eyelid." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022299" ; a owl:Class ; rdfs:label "upper eyelid nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001712 ] ) ] . obo:UBERON_0022302 obo:IAO_0000115 "A branch of the ciliary ganglion that innervates the ciliary muscles, the iris, and the tunics of the eyeball." ; obo:UBPROP_0000010 "Contains preganglionic parasympathetic axons." ; oboInOwl:hasDbXref "FMA:7041", "SCTID:417598000", "Wikipedia:Short_ciliary_nerves" ; oboInOwl:hasExactSynonym "lower branch of ciliary ganglion" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nervi ciliares breves", "nervi ciliares brevis", "short ciliary nerve" ; oboInOwl:id "UBERON:0022302" ; a owl:Class ; rdfs:label "short ciliary nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001605 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001769 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0012430 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002058 ] ) ] . obo:UBERON_0022303 obo:IAO_0000115 "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." ; obo:IAO_0000116 "this is currently used to group some cellular layers that may not strictly conform to the CARO definition of cell-part layer. Consider genericisizing and introducing subtypes for cellular layer, fibrous layer and cell soma layer" ; oboInOwl:hasBroadSynonym "lamina", "layer" ; oboInOwl:hasDbXref "NLX:149357" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022303" ; oboInOwl:inSubset core:cumbo ; a owl:Class ; rdfs:label "nervous system cell part layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005162 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002124 ] ) ] . obo:UBERON_0022350 obo:IAO_0000115 "Serous membrane layer that is adjacent to and lines an organ." ; oboInOwl:hasDbXref "FMA:15860" ; oboInOwl:hasExactSynonym "visceral wall of serous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022350" ; a owl:Class ; rdfs:label "visceral serous membrane" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000062 ] ) ] . obo:UBERON_0022351 obo:IAO_0000115 "Serous membrane layer that lines to a body cavity." ; oboInOwl:hasBroadSynonym "cavity lining" ; oboInOwl:hasDbXref "FMA:15859", "MA:0002448" ; oboInOwl:hasExactSynonym "parietal wall of serous membrane" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022351" ; a owl:Class ; rdfs:label "parietal serous membrane" ; owl:equivalentClass _:genid158017 . obo:UBERON_0022355 obo:IAO_0000115 "The layer of endometrial epithelium adjacent to the uterine cavity." ; oboInOwl:hasDbXref "FMA:86492", "NCIT:C32189" ; oboInOwl:hasExactSynonym "pars basalis of endometrium", "stratum basalis of endometrium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022355" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "basal layer of endometrium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004811 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013769 ] ) ] . obo:UBERON_0022357 oboInOwl:hasDbXref "FMA:14652" ; oboInOwl:hasExactSynonym "ileal mesentery", "ileum mesentery", "mesoileum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022357" ; a owl:Class ; rdfs:label "mesentery of ileum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_0022358 obo:IAO_0000115 "A blood vessel of the placenta." ; oboInOwl:hasBroadSynonym "placental vessel" ; oboInOwl:hasDbXref "SCTID:280716005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022358" ; a owl:Class ; rdfs:label "placenta blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:UBERON_0022360 obo:IAO_0000115 "A mammary gland duct that is part of a male organism. This structure typically regresses." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022360" ; a owl:Class ; rdfs:label "male mammary gland duct" ; owl:equivalentClass _:genid158043 . obo:UBERON_0022361 obo:IAO_0000115 "A specific region of the foregut into the area in which the lung will develop." ; oboInOwl:hasDbXref "SCTID:34922002" ; oboInOwl:hasExactSynonym "lung field" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0022361" ; a owl:Class ; rdfs:label "lung field" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003258 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007688 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0023879 obo:IAO_0000115 "A set of neural structures that subserve a specific function, e.g., visual system." ; obo:IAO_0000116 "this class was inherited from NIFSTD as part of the replacement of NIFSTD with Uberon. It may be obsoleted in the future" ; oboInOwl:hasDbXref "NLXANAT:090802" ; oboInOwl:hasExactSynonym "neural system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0023879" ; a owl:Class ; rdfs:label "neural system" ; rdfs:subClassOf obo:UBERON_0011216, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0024045 obo:IAO_0000115 "White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei." ; oboInOwl:hasDbXref "NLXANAT:20081249" ; oboInOwl:hasExactSynonym "white matter of the cerebellar cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0024045" ; a owl:Class ; rdfs:label "white matter of the cerebellar cortex" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002129 ] ) ] . obo:UBERON_0025261 oboInOwl:hasDbXref "BIRNLEX:749" ; oboInOwl:hasExactSynonym "thalamic fiber tracts" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0025261" ; a owl:Class ; rdfs:label "thalamic fiber tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001897 ] ) ] . obo:UBERON_0025525 obo:IAO_0000115 "The part of the central nervous system that is involved with movement." ; oboInOwl:hasDbXref "NLXANAT:090805" ; oboInOwl:hasExactSynonym "motor system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0025525" ; a owl:Class ; rdfs:comment "It consists of the pyramidal and extrapyramidal system" ; rdfs:label "motor system" ; rdfs:subClassOf obo:UBERON_0023879 . obo:UBERON_0025533 obo:IAO_0000115 "The sensory system for the sense of proprioception." ; oboInOwl:hasDbXref "NLXANAT:090814" ; oboInOwl:hasExactSynonym "proprioceptive system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0025533" ; a owl:Class ; rdfs:label "proprioceptive system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0023879 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0019230 ] ) ] . obo:UBERON_0026246 oboInOwl:hasDbXref "BIRNLEX:1500" ; oboInOwl:hasExactSynonym "sacral spinal cord white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0026246" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral spinal cord white matter" ; owl:disjointWith obo:UBERON_0029503 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005843 ] ) ] . obo:UBERON_0026386 oboInOwl:hasDbXref "BIRNLEX:1639" ; oboInOwl:hasExactSynonym "lumbar spinal cord white matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0026386" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar spinal cord white matter" ; owl:disjointWith obo:UBERON_0029636 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002792 ] ) ] . obo:UBERON_0029503 oboInOwl:hasDbXref "BIRNLEX:1491" ; oboInOwl:hasExactSynonym "sacral spinal cord gray matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0029503" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral spinal cord gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005843 ] ) ] . obo:UBERON_0029636 oboInOwl:hasDbXref "BIRNLEX:1624" ; oboInOwl:hasExactSynonym "lumbar spinal cord gray matter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0029636" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar spinal cord gray matter" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002020 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002792 ] ) ] . obo:UBERON_0030276 oboInOwl:hasDbXref "BIRNLEX:891" ; oboInOwl:hasExactSynonym "lumbar spinal cord ventral horn" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lumbar spinal cord anterior horn" ; oboInOwl:id "UBERON:0030276" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lumbar spinal cord ventral horn" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0029636 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002792 ] ) ] . obo:UBERON_0032748 oboInOwl:hasDbXref "BIRNLEX:1457" ; oboInOwl:hasExactSynonym "sacral spinal cord ventral horn" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sacral spinal cord anterior horn" ; oboInOwl:id "UBERON:0032748" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sacral spinal cord ventral horn" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0029503 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002257 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005843 ] ) ] . obo:UBERON_0034670 obo:IAO_0000115 "A taste bud that is located on the soft palate, in the roof of the mouth." ; obo:UBPROP_0000008 "In the mouse, Fungiform and palatal taste buds are innervated by the geniculate ganglion cells of the facial nerve[DOI:10.1523/JNEUROSCI.5142-05.2006]" ; oboInOwl:hasExactSynonym "taste bud of palate" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034670" ; a owl:Class ; rdfs:label "palatal taste bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014453 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001733 ] ) ] . obo:UBERON_0034681 obo:IAO_0000115 "Any organ that is the primary organ of vocalization behavior. Examples: The laryngeal vocal cord (humans), the syrinx (birds)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034681" ; a owl:Class ; rdfs:label "vocal organ" ; owl:equivalentClass _:genid158119 . obo:UBERON_0034705 obo:IAO_0000115 "An embryonic or larval epithelium that is committed to form part of the nervous system." ; oboInOwl:hasBroadSynonym "neurepithelium" ; oboInOwl:hasDbXref "AEO:0001008", "BTO:0000314", "EHDAA2_RETIRED:0004654", "FMA:64807" ; oboInOwl:hasExactSynonym "embryonic neuroepithelium", "neuroepithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034705" ; a owl:Class ; rdfs:label "developing neuroepithelium" ; rdfs:subClassOf obo:UBERON_0000483, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001016 ] . obo:UBERON_0034706 obo:IAO_0000115 "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." ; oboInOwl:hasDbXref "AEO:0001009" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034706" ; a owl:Class ; rdfs:label "proliferating neuroepithelium" ; rdfs:subClassOf obo:UBERON_0034705 . obo:UBERON_0034707 obo:IAO_0000115 "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." ; oboInOwl:hasDbXref "AEO:0001010" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034707" ; a owl:Class ; rdfs:label "differentiating neuroepithelium" ; rdfs:subClassOf obo:UBERON_0034705, _:genid158131 . obo:UBERON_0034708 obo:UBPROP_0000011 "In the cerebellum, some neuronal precursors enter the marginal zone to form clusters of neurons called nuclei[NBK10047]" ; oboInOwl:hasDbXref "DHBA:12695", "EHDAA2:0001152", "EMAPA:17789" ; oboInOwl:hasExactSynonym "marginal zone of cerebellum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "MZCB" ; oboInOwl:id "UBERON:0034708" ; a owl:Class ; rdfs:label "cerebellum marginal layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 ] ) ] . obo:UBERON_0034709 oboInOwl:hasDbXref "DHBA:12694", "EMAPA:32916" ; oboInOwl:hasExactSynonym "marginal zone of hindbrain" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "MZH" ; oboInOwl:id "UBERON:0034709" ; a owl:Class ; rdfs:label "hindbrain marginal layer" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0034710 oboInOwl:hasDbXref "EHDAA2:0001267", "EMAPA:17585" ; oboInOwl:hasExactSynonym "spinal cord lateral wall ventricular layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034710" ; a owl:Class ; rdfs:label "spinal cord ventricular layer" ; rdfs:subClassOf _:genid160403 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006241 ] ) ] . obo:UBERON_0034711 obo:IAO_0000115 "The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate." ; oboInOwl:hasDbXref "EMAPA:35261" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034711" ; a owl:Class ; rdfs:label "cortical preplate" ; rdfs:subClassOf obo:UBERON_0014950 . obo:UBERON_0034713 obo:IAO_0000115 "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "cranial nerve fiber bundle", "cranial nerve fiber tract", "cranial nerve or tract", "neuron projection bundle from brain" ; oboInOwl:id "UBERON:0034713" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "cranial neuron projection bundle" ; rdfs:subClassOf obo:UBERON_0000122, [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000033 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0000955 ] . obo:UBERON_0034714 obo:IAO_0000115 "A cranial nerve fiber tract that innervates the parietal eye." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "epiphyseal nerve" ; oboInOwl:id "UBERON:0034714" ; a owl:Class ; rdfs:comment "This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893]" ; rdfs:label "epiphyseal tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001899 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034713 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004869 ] ) ] . obo:UBERON_0034715 obo:IAO_0000115 "A cranial nerve fiber tract that innervates the pineal body." ; oboInOwl:hasDbXref "FMA:77600" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pineal nerve" ; oboInOwl:id "UBERON:0034715" ; a owl:Class ; rdfs:comment "This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893]" ; rdfs:label "pineal tract" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0034714 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001899 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034713 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001905 ] ) ] . obo:UBERON_0034717 obo:IAO_0000115 "A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034717" ; a owl:Class ; rdfs:label "integumental taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 ] ) ] . obo:UBERON_0034719 obo:IAO_0000115 "A taste bud that is located on a lip." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034719" ; a owl:Class ; rdfs:label "lip taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0034720 obo:IAO_0000115 "A taste bud that is located on the skin of the head." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034720" ; a owl:Class ; rdfs:label "head taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001084 ] ) ] . obo:UBERON_0034721 obo:IAO_0000115 "A taste bud that is located in the pharynx." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034721" ; a owl:Class ; rdfs:label "pharyngeal taste bud" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006562 ] ) ] . obo:UBERON_0034722 obo:IAO_0000115 "A taste bud that is located on the roof of the mouth." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034722" ; a owl:Class ; rdfs:label "mouth roof taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007375 ] ) ] . obo:UBERON_0034724 obo:IAO_0000115 "A taste bud that is located in the esophagus." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034724" ; a owl:Class ; rdfs:label "esophageal taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0034726 obo:IAO_0000115 "A taste bud that is located on the skin of the trunk." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034726" ; a owl:Class ; rdfs:label "trunk taste bud" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001727 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001085 ] ) ] . obo:UBERON_0034728 obo:IAO_0000115 "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa." ; oboInOwl:hasDbXref "EMAPA:37957", "FMA:5866", "MESH:D017776", "SCTID:276145003", "Wikipedia:Autonomic_nerve" ; oboInOwl:hasExactSynonym "nervus visceralis", "visceral nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034728" ; a owl:Class ; rdfs:label "autonomic nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002410 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0036264 ], [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001805 ] . obo:UBERON_0034729 oboInOwl:hasDbXref "EMAPA:37958", "SCTID:181098007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034729" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "sympathetic nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001806 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000013 ] ) ] . obo:UBERON_0034730 obo:UBPROP_0000001 "Telencephalic white matter which extends between the olfactory bulb and the ipsilateral dorsal telencephalon and carries secondary olfactory fibers. From Neuroanatomy of the Zebrafish Brain." ; oboInOwl:hasDbXref "TAO:0000229", "ZFA:0000229" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lateral olfactory tract", "tractus olfactorius lateralis" ; oboInOwl:id "UBERON:0034730" ; a owl:Class ; rdfs:label "olfactory tract linking bulb to ipsilateral dorsal telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002265 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000203 ] ) ] . obo:UBERON_0034736 obo:IAO_0000115 "Any ligament that connects the coracoid process with the clavicle." ; oboInOwl:hasDbXref "FMA:26029", "SCTID:361899005", "Wikipedia:Coracoclavicular_ligament" ; oboInOwl:hasExactSynonym "accessory ligament of acromioclavicular joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034736" ; a owl:Class ; rdfs:label "coracoclavicular ligament" ; rdfs:subClassOf _:genid160493 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008846 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006633 ] ) ] . obo:UBERON_0034762 obo:IAO_0000115 "Any sweat gland that is part of an areola." ; oboInOwl:hasDbXref "FMA:62149" ; oboInOwl:hasExactSynonym "areolar aprocine sweat gland", "sweat gland of areola" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034762" ; a owl:Class ; rdfs:label "areolar sweat gland" ; rdfs:subClassOf obo:UBERON_0000382 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001820 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002032 ] ) ] . obo:UBERON_0034763 obo:IAO_0000115 "Any commissure within the hindbrain." ; oboInOwl:hasDbXref "TAO:0002199", "ZFA:0001692" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034763" ; a owl:Class ; rdfs:label "hindbrain commissure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001020 _:genid158252 ) ] . obo:UBERON_0034765 obo:IAO_0000115 "The zone of skin that overlaps with the glabella region." ; obo:UBPROP_0000008 "in humans this area is normally hairless" ; oboInOwl:hasBroadSynonym "glabella" ; oboInOwl:hasDbXref "SCTID:244083007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034765" ; a owl:Class ; rdfs:label "glabella skin" ; rdfs:subClassOf obo:UBERON_0000014, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0034766 ] . obo:UBERON_0034766 obo:IAO_0000115 "A region of the forehead corresponding to the space between the eyebrows and above the nose." ; oboInOwl:hasDbXref "Wikipedia:Glabella" ; oboInOwl:hasNarrowSynonym "glabella" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034766" ; a owl:Class ; rdfs:label "glabella region" ; rdfs:subClassOf obo:UBERON_0001444, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008200 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0016440 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0034765 ] . obo:UBERON_0034768 obo:IAO_0000115 "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034768" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "morphological feature" ; rdfs:subClassOf obo:UBERON_0000061, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0000052 ] . obo:UBERON_0034769 oboInOwl:hasDbXref "FMA:79770", "NCIT:C41168" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034769" ; a owl:Class ; rdfs:label "lymphomyeloid tissue" ; rdfs:subClassOf obo:UBERON_0015757 . obo:UBERON_0034873 obo:IAO_0000115 "Any substance in the body or expelled from the body that is in a gaseous state." ; oboInOwl:hasDbXref "FMA:84580" ; oboInOwl:hasExactSynonym "gas in anatomical space", "portion of gas in anatomical space" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034873" ; a owl:Class ; rdfs:label "bodily gas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000463 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001547 ] ) ] . obo:UBERON_0034874 obo:IAO_0000115 "Any portion of gas located in a part of the respiratory system that is composed primarily of air." ; oboInOwl:hasDbXref "FMA:84581" ; oboInOwl:hasExactSynonym "respiratory air", "respiratory system air" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034874" ; a owl:Class ; rdfs:label "air in respiratory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034873 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CHEBI_25805 ] ) ] . obo:UBERON_0034875 oboInOwl:hasDbXref "EHDAA2:0001472", "EMAPA:32796" ; oboInOwl:hasExactSynonym "pituitary primordium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034875" ; a owl:Class ; rdfs:label "future pituitary gland" ; rdfs:subClassOf _:genid160538, _:genid160540 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] . obo:UBERON_0034876 obo:IAO_0000115 "The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland." ; oboInOwl:hasDbXref "EHDAA2:0004434", "EMAPA:16647" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "neurohypohysial region", "neurohypophyseal bud" ; oboInOwl:id "UBERON:0034876" ; a owl:Class ; rdfs:label "future neurohypophysis" ; rdfs:subClassOf _:genid160547, _:genid160549 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002198 ] ) ] . obo:UBERON_0034878 obo:IAO_0000115 "The area of axial mesoderm that develops into the prechordal plate." ; oboInOwl:hasExactSynonym "prechordal mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034878" ; a owl:Class ; rdfs:label "prechordal mesoderm" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005423 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003068 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003063 ] ) ] . obo:UBERON_0034898 obo:IAO_0000115 "The thickened ridge of bone that contains the tooth sockets on the premaxilla." ; oboInOwl:hasDbXref "AAO:0000397" ; oboInOwl:hasExactSynonym "pars dentalis of premaxilla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034898" ; a owl:Class ; rdfs:label "alveolar ridge of premaxilla" ; rdfs:subClassOf _:genid160565 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004103 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002244 ] ) ] . obo:UBERON_0034901 obo:IAO_0000115 "The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. These emerging postganglionic nerves synapse with preganglionic nerves from the thoracic spinal cord. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things." ; oboInOwl:hasDbXref "FMA:6261", "SCTID:280533000", "Wikipedia:Cervical_ganglia" ; oboInOwl:hasExactSynonym "cervical part of sympathetic trunk", "cervical sympathetic chain", "cervical sympathetic trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034901" ; a owl:Class ; rdfs:label "cervical sympathetic nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005434 ] ) ] . obo:UBERON_0034902 oboInOwl:hasDbXref "EMAPA:37656", "FMA:6264", "MA:0001164" ; oboInOwl:hasExactSynonym "sacral part of sympathetic trunk", "sacral sympathetic chain", "sacral sympathetic trunk" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pelvic sympathetic nerve trunk", "pelvic sympathetic trunk" ; oboInOwl:id "UBERON:0034902" ; a owl:Class ; rdfs:label "sacral sympathetic nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005473 ] ) ] . obo:UBERON_0034903 obo:IAO_0000115 "Endocardium that is part of the left atrium." ; obo:UBPROP_0000001 "Endocardium of atrium which is continuous with the tunica intima of the trunk of pulmonary vein." ; oboInOwl:hasDbXref "FMA:7286", "SCTID:190064008", "VHOG:0001226" ; oboInOwl:hasExactSynonym "endocardium of left atrium", "left atrial endocardium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "left atrium endocardial tissue" ; oboInOwl:id "UBERON:0034903" ; a owl:Class ; rdfs:label "left atrium endocardium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002079 ] ) ] . obo:UBERON_0034905 oboInOwl:hasExactSynonym "lumen of gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034905" ; a owl:Class ; rdfs:label "gland lumen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002530 ] ) ] . obo:UBERON_0034907 obo:IAO_0000115 "Parenchymal tissue that forms the pineal gland." ; oboInOwl:hasDbXref "NCIT:C41834", "UMLS:C1519088" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034907" ; a owl:Class ; rdfs:label "pineal parenchyma" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001905 ] ) ] . obo:UBERON_0034908 obo:IAO_0000115 "Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034908" ; a owl:Class ; rdfs:label "scapular muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0006849 ] ) ] . obo:UBERON_0034909 obo:IAO_0000115 "A cranial suture in the midline of the skull that connects the left and right maxilla bones." ; oboInOwl:hasDbXref "FMA:52963" ; oboInOwl:hasExactSynonym "intermaxillary suture of skull" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034909" ; a owl:Class ; rdfs:comment "in humans, the upper maxillae (the upper jaw) is composed of the right and left maxilla bones, which are fused in the midline at the intermaxillary suture to form the upper jaw.[https://orcid.org/0000-0001-5889-4463]" ; rdfs:label "intermaxillary suture" ; rdfs:subClassOf obo:UBERON_0009199, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ; owl:equivalentClass _:genid158348 . obo:UBERON_0034921 obo:IAO_0000115 "An multicellular anatomical structure that has subparts of multiple organs as a part." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "CARO:0020001" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomical cluster" ; oboInOwl:id "UBERON:0034921" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "multi organ part structure" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000064 ] . obo:UBERON_0034922 obo:IAO_0000115 "A cluster of cells, largely surrounded by a morphological boundary." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "CARO:0020002", "FMA:62807" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034922" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "cell cluster" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000015 ] . obo:UBERON_0034923 obo:IAO_0000115 "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "CARO:0020000", "FBbt:00007276" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034923" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "disconnected anatomical group" ; rdfs:subClassOf obo:UBERON_0000465, [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0010001 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000061 ], [ a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:UBERON_0000061 ; owl:onProperty obo:RO_0002180 ] . obo:UBERON_0034925 obo:IAO_0000115 "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." ; obo:IAO_0000116 "resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected" ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034925" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical collection" ; rdfs:subClassOf obo:UBERON_0000465, [ a owl:Restriction ; owl:onProperty obo:RO_0002351 ; owl:someValuesFrom obo:UBERON_0000061 ] . obo:UBERON_0034926 obo:IAO_0000115 "An anatomical collection that is arranged in a line." ; obo:IAO_0000116 "resolve if this should be a subclass of or merged with aligned anatomical group." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "FBbt:00100152" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034926" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical row" ; rdfs:subClassOf obo:UBERON_0034925 . obo:UBERON_0034928 oboInOwl:hasDbXref "FMA:19623" ; oboInOwl:hasExactSynonym "dorsum of penis", "dorsum penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034928" ; a owl:Class ; rdfs:label "dorsal surface of penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0034929 obo:IAO_0000115 "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034929" ; a owl:Class ; rdfs:label "external soft tissue zone" ; rdfs:subClassOf obo:UBERON_0010000, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000475 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000014 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001015 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001021 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002049 ] . obo:UBERON_0034932 obo:IAO_0000115 "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." ; oboInOwl:hasDbXref "BTO:0001513" ; oboInOwl:hasExactSynonym "biliary system epithelium" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "biliary epithelium", "biliary tract epithelium" ; oboInOwl:id "UBERON:0034932" ; a owl:Class ; rdfs:label "epithelium of biliary system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002294 ] ) ] . obo:UBERON_0034933 obo:IAO_0000115 "Any organ component layer that consists of smooth muscle tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034933" ; a owl:Class ; rdfs:label "layer of smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001135 ] ) ] . obo:UBERON_0034940 obo:IAO_0000115 "An enlarged chamber in the blood sinus capable of accumulating a large volume of blood." ; oboInOwl:hasDbXref "ZFA:0007073" ; oboInOwl:hasExactSynonym "blood sinus cavity", "blood sinus lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034940" ; a owl:Class ; rdfs:label "venous sinus cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0006615 ] ) ] . obo:UBERON_0034944 oboInOwl:hasDbXref "FMA:55268" ; oboInOwl:hasExactSynonym "organ sector", "organ zonal region", "organ zone" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "organ region with floating fiat boundary" ; oboInOwl:id "UBERON:0034944" ; a owl:Class ; rdfs:label "zone of organ" ; rdfs:subClassOf obo:UBERON_0000064 . obo:UBERON_0034945 obo:IAO_0000115 "Any gaseous product of an excretory process." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034945" ; a owl:Class ; rdfs:label "excreted gas" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034873 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0007588 ] ) ] . obo:UBERON_0034946 obo:IAO_0000115 "Any excreted gas that is produced by the digestive tract." ; oboInOwl:hasDbXref "FMA:78440" ; oboInOwl:hasNarrowSynonym "flatulence", "flatus", "intestinal gas" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034946" ; a owl:Class ; rdfs:comment "In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum" ; rdfs:label "gas excreted from digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034945 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ] . obo:UBERON_0034947 obo:IAO_0000115 "Any portion of gas located in a part of the respiratory system." ; oboInOwl:hasExactSynonym "respiratory gas", "respiratory system gas" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034947" ; a owl:Class ; rdfs:label "gas in respiratory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034873 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0034948 obo:IAO_0000115 "Any portion of gas located in a part of the respiratory system that is composed primarily of carbon dioxide." ; oboInOwl:hasExactSynonym "respiratory CO2", "respiratory system CO2" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034948" ; a owl:Class ; rdfs:label "carbon dioxide in respiratory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034873 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CHEBI_16526 ] ) ] . obo:UBERON_0034953 obo:IAO_0000115 "A population of lymphatic endothelial cell precursors that will form the lymph vessels." ; oboInOwl:hasDbXref "NCIT:C34262", "UMLS:C1514424" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "primary lymph sac" ; oboInOwl:id "UBERON:0034953" ; a owl:Class ; rdfs:label "embryonic lymph sac" ; rdfs:subClassOf obo:UBERON_0007499, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], _:genid160691 . obo:UBERON_0034969 oboInOwl:hasDbXref "NCIT:C25787", "UMLS:C1512086" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "duct epithelium", "ductal epithelium" ; oboInOwl:id "UBERON:0034969" ; a owl:Class ; rdfs:label "epithelial layer of duct" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 ] ; owl:equivalentClass _:genid158433 . obo:UBERON_0034994 oboInOwl:hasDbXref "DHBA:12682", "EMAPA:32917" ; oboInOwl:hasExactSynonym "hindbrain mantle layer" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034994" ; a owl:Class ; rdfs:label "hindbrain cortical intermediate zone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004040 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) ] . obo:UBERON_0034995 obo:IAO_0000115 "Mesenchyme that is part of a developing jaw [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32907", "EMAPA:35454" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0034995" ; a owl:Class ; rdfs:label "jaw mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ] ) ] . obo:UBERON_0035004 oboInOwl:hasDbXref "EMAPA:35702" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035004" ; a owl:Class ; rdfs:label "preputial swelling" ; rdfs:subClassOf obo:UBERON_0005423, _:genid160709 . obo:UBERON_0035005 oboInOwl:hasDbXref "EMAPA:29220" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prepuce of male" ; oboInOwl:id "UBERON:0035005" ; a owl:Class ; rdfs:label "preputial swelling of male" ; rdfs:subClassOf _:genid160715 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid158450 ] . obo:UBERON_0035006 oboInOwl:hasDbXref "EMAPA:30478" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "prepuce of female" ; oboInOwl:id "UBERON:0035006" ; a owl:Class ; rdfs:label "preputial swelling of female" ; rdfs:subClassOf _:genid160722 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100 ] ) ] . obo:UBERON_0035020 oboInOwl:hasDbXref "EMAPA:37798", "FMA:18157", "MA:0001151" ; oboInOwl:hasExactSynonym "left vagus neural trunk", "trunk of left vagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior vagus X nerve trunk" ; oboInOwl:id "UBERON:0035020" ; a owl:Class ; rdfs:label "left vagus X nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003535 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0035021 oboInOwl:hasDbXref "EMAPA:37799", "FMA:18151", "MA:0001152" ; oboInOwl:hasExactSynonym "right vagus neural trunk", "trunk of right vagus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "posterior vagus X nerve trunk" ; oboInOwl:id "UBERON:0035021" ; a owl:Class ; rdfs:label "right vagus X nerve trunk" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003535 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001016 ] ) ] . obo:UBERON_0035032 obo:IAO_0000115 "Either the external or internal abdominal oblique muscles." ; oboInOwl:hasDbXref "EMAPA:35603", "MA:0003024", "MESH:D000071596" ; oboInOwl:hasExactSynonym "oblique abdominal muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035032" ; a owl:Class ; rdfs:label "abdominal oblique muscle" ; rdfs:subClassOf obo:UBERON_0002461, obo:UBERON_0014892, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] . obo:UBERON_0035034 obo:IAO_0000115 "An epithelium that is part of an eyelid [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:32758", "MA:0003163" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035034" ; a owl:Class ; rdfs:label "eyelid epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ] . obo:UBERON_0035036 obo:IAO_0000115 "An epithelium that is part of a naris [Automatically generated definition]." ; oboInOwl:hasDbXref "EMAPA:35959", "MA:0003172" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035036" ; a owl:Class ; rdfs:label "naris epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000003 ] ) ] . obo:UBERON_0035037 oboInOwl:hasDbXref "EMAPA:32904", "MA:0003220" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035037" ; a owl:Class ; rdfs:label "jaw epithelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011595 ] ) ] . obo:UBERON_0035038 obo:IAO_0000115 "The fibro-osseous passageway on the palmar side of the wrist that connects the distal forearm to the middle compartment of the deep plane of the palm." ; oboInOwl:hasDbXref "FMA:42352", "Wikipedia:Carpal_tunnel" ; oboInOwl:hasExactSynonym "carpal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "carpel tunnel" ; oboInOwl:id "UBERON:0035038" ; a owl:Class ; rdfs:label "carpal tunnel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004111 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0001148 ] ) ] . obo:UBERON_0035039 oboInOwl:hasDbXref "SCTID:277967008" ; oboInOwl:hasExactSynonym "hemorrhoidal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035039" ; a owl:Class ; rdfs:label "rectal artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001052 ] ) ] . obo:UBERON_0035045 obo:IAO_0000115 "Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035045" ; a owl:Class ; rdfs:label "parotid gland intralobular duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014719 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0035048 obo:IAO_0000115 "Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035048" ; a owl:Class ; rdfs:label "parotid gland excretory duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0035049 obo:IAO_0000115 "Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized]." ; oboInOwl:hasDbXref "FMA:60052" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035049" ; a owl:Class ; rdfs:label "excretory duct of salivary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0035050 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035050" ; a owl:Class ; rdfs:label "excretory duct" ; rdfs:subClassOf obo:UBERON_0000058 . obo:UBERON_0035053 oboInOwl:hasDbXref "FMA:60053" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035053" ; a owl:Class ; rdfs:label "interlobular duct of salivary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014716 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001044 ] ) ] . obo:UBERON_0035073 oboInOwl:hasDbXref "FMA:70617" ; oboInOwl:hasExactSynonym "ductal part of eccrine sweat gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035073" ; a owl:Class ; rdfs:label "duct of eccrine sweat gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000423 ] ) ] . obo:UBERON_0035074 oboInOwl:hasDbXref "FMA:70643" ; oboInOwl:hasExactSynonym "ductal part of apocrine sweat gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035074" ; a owl:Class ; rdfs:label "duct of apocrine sweat gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000058 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000382 ] ) ] . obo:UBERON_0035075 oboInOwl:hasDbXref "FMA:71193" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "lobe or lobule of thymus" ; oboInOwl:id "UBERON:0035075" ; a owl:Class ; rdfs:label "thymus subunit" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ] . obo:UBERON_0035078 obo:IAO_0000115 "Any of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035078" ; a owl:Class ; rdfs:label "parotid gland interlobular duct" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0014716 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0035083 obo:IAO_0000115 "A vertebra that has a transverse process." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "TP vertebra", "pygal vertebra" ; oboInOwl:id "UBERON:0035083" ; a owl:Class ; rdfs:label "transverse process-bearing vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002412 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001077 ] ) ] . obo:UBERON_0035091 obo:IAO_0000115 "A post-anal tail that attaches outside the tail." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035091" ; a owl:Class ; rdfs:label "extrinsic post-anal tail muscle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003665 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0010742 ] ) ] . obo:UBERON_0035096 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035096" ; a owl:Class ; rdfs:label "fascia of tail" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0008982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_0035097 obo:IAO_0000115 "A muscle that attaches to the iliac crest and to a caudal vertebra." ; obo:UBPROP_0000008 "In anolis, This muscle lies deep to the m. extensor caudae medialis and originates via fleshy fibers from the iliac crest (Fig. 3A,B). It inserts via fleshy fibers onto the horizontal intramuscular septum as well as the chevron bones and dorsal aspect of the transverse processes of Ca3-6 or 7. The fibers of m. iliocaudalis are noticeably bipennate[PMID:22753107]" ; oboInOwl:hasExactSynonym "M. iliocaudalis", "iliocaudalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035097" ; a owl:Class ; rdfs:label "iliocaudalis muscle" ; rdfs:subClassOf obo:UBERON_0035091 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001630 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006071 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001095 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0014437 ] ) ] . obo:UBERON_0035102 obo:IAO_0000115 "A transverse process that is part of a caudal vertebra." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035102" ; a owl:Class ; rdfs:label "transverse process of caudal vertebra" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001077 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001095 ] ) ] . obo:UBERON_0035104 oboInOwl:hasDbXref "FMA:19646" ; oboInOwl:hasExactSynonym "penile raphe", "raphe penis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035104" ; a owl:Class ; rdfs:label "raphe of penis" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035106 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0000989 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002358 ] ) ] . obo:UBERON_0035105 obo:IAO_0000115 "Any of the two testis-carrying compartments of the scrotum." ; oboInOwl:hasDbXref "FMA:18251" ; oboInOwl:hasExactSynonym "scrotal comartment", "scrotal sac", "testis comartment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035105" ; a owl:Class ; rdfs:label "sac of scrotum" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001300 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0000473 ; owl:onProperty obo:RO_0002180 ; owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ] . obo:UBERON_0035106 obo:IAO_0000115 "The perineal raphe extends from the anus, through the mid-line of the scrotum (scrotal raphe) and upwards through the posterior mid-line aspect of the penis (penile raphe)." ; obo:UBPROP_0000011 "It is the result of a fetal developmental phenomenon whereby the scrotum (the developmental equivalent of the labia in females) and penis close toward the midline and fuse. The resulting ridge of tissue is evident as the perineal raphe" ; oboInOwl:hasDbXref "FMA:20244", "Wikipedia:Perineal_raphe" ; oboInOwl:hasExactSynonym "perineal raphe", "raphe perinealis", "raphe perinei" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035106" ; a owl:Class ; rdfs:label "raphe of perineum" ; rdfs:subClassOf _:genid160861 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid158592 ] . obo:UBERON_0035109 obo:IAO_0000115 "A nerve that innervates the sole of the foot. Planar nerves arise from the posterior branch of the tibial nerve." ; oboInOwl:hasDbXref "NCIT:C77674", "SCTID:181074000", "UMLS:C0446824", "Wikipedia:Plantar_nerve", "https://upload.wikimedia.org/wikipedia/commons/thumb/1/16/Gray834.svg/180px-Gray834.svg.png" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "nerve, plantar" ; oboInOwl:id "UBERON:0035109" ; a owl:Class ; rdfs:comment "Divided into medial and plantar based on the location of the foot supplied" ; rdfs:label "plantar nerve" ; rdfs:subClassOf _:genid158606, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001323 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0008338 ] ) ] . obo:UBERON_0035110 obo:IAO_0000115 "A plantar nerve that supplies the lateral side of the plantar part of the foot, including pedal digit 5." ; oboInOwl:hasDbXref "FMA:44724", "SCTID:181083005", "Wikipedia:Lateral_plantar_nerve" ; oboInOwl:hasExactSynonym "external plantar nerve", "nervus plantaris lateralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035110" ; a owl:Class ; rdfs:label "lateral plantar nerve" ; owl:disjointWith obo:UBERON_0035111 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035109 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0003635 ] ) ] . obo:UBERON_0035111 obo:IAO_0000115 "A plantar nerve that supplies the medial side of the plantar part of the foot, including pedal digit 1." ; oboInOwl:hasDbXref "FMA:44716", "SCTID:181082000", "Wikipedia:Medial_plantar_nerve" ; oboInOwl:hasExactSynonym "internal plantar nerve", "nervus plantaris medialis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035111" ; a owl:Class ; rdfs:label "medial plantar nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035109 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0003631 ] ) ] . obo:UBERON_0035112 obo:IAO_0000115 "Any of the muscles that are entirely within the body part or segment moved by them." ; obo:IAO_0000116 "ideally we would like to classify under this class automatically but this is difficult to do without applying external rules. Note that logical definitions that use this class as a genus may not be strictly correct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035112" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "intrinsic muscle" ; rdfs:subClassOf obo:UBERON_0014892 . obo:UBERON_0035115 obo:IAO_0000115 "A space or gap between the left and right central incisors, on either the upper or lower jaw." ; oboInOwl:hasExactSynonym "interdental space, central incisors", "midline diastema" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035115" ; a owl:Class ; rdfs:label "diastema between central incisors" ; rdfs:subClassOf obo:UBERON_0012111, [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0001708 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035119 [ a owl:Restriction ; owl:onClass obo:UBERON_0018551 ; owl:onProperty obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0035116 obo:IAO_0000115 "A space or gap between the left and right central incisors on the upper jaw." ; oboInOwl:hasExactSynonym "interdental space between maxillary central incisors", "interdental space, upper central incisors", "midline maxillary diastema" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035116" ; a owl:Class ; rdfs:label "diastema between upper central incisors" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0003277 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0018603 ; owl:onProperty obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_0035117 obo:IAO_0000115 "A space or gap between the left and right central incisors on the lower jaw." ; oboInOwl:hasExactSynonym "interdental space between mandibular central incisors", "interdental space, lower central incisors", "midline mandibular diastema" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035117" ; a owl:Class ; rdfs:label "diastema between lower central incisors" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0003278 ], [ a owl:Restriction ; owl:onClass obo:UBERON_0018601 ; owl:onProperty obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035115 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_0035118 obo:IAO_0000115 "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." ; obo:IAO_0000116 "Note that we treat any material entity that is ingested as an anatomical structure by defintion, although this may be expanding the CARO usage somewhat" ; oboInOwl:hasExactSynonym "digestive tract contents" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ingested material entity" ; oboInOwl:id "UBERON:0035118" ; a owl:Class ; rdfs:label "material entity in digestive tract" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0006909 ] ) ] . obo:UBERON_0035119 obo:IAO_0000115 "A space or gap any two incisors. This may be a midline diastema between central incisors, or a diastema located entirely in a single jaw quadrant between lateral incisors." ; oboInOwl:hasExactSynonym "incisor diastema", "interdental space, incisors" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035119" ; a owl:Class ; rdfs:label "diastema between incisors" ; rdfs:subClassOf obo:UBERON_0012111, [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0001708 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012111 [ a owl:Restriction ; owl:onClass obo:UBERON_0001098 ; owl:onProperty obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] . obo:UBERON_0035127 obo:IAO_0000115 "Any of the sutures of the hard palate." ; oboInOwl:hasExactSynonym "palatine suture" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035127" ; a owl:Class ; rdfs:label "suture of hard palate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003216 ] ) ] . obo:UBERON_0035128 oboInOwl:hasDbXref "EMAPA:32631" ; oboInOwl:hasExactSynonym "hand cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035128" ; a owl:Class ; rdfs:label "manus cartilage element" ; rdfs:subClassOf _:genid160934 ; owl:equivalentClass _:genid158663 . obo:UBERON_0035129 oboInOwl:hasDbXref "EMAPA:32657" ; oboInOwl:hasExactSynonym "foot cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035129" ; a owl:Class ; rdfs:label "pes cartilage element" ; rdfs:subClassOf _:genid160943 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0015063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0035130 oboInOwl:hasBroadSynonym "ossicle element" ; oboInOwl:hasExactSynonym "auditory skeletal element", "middle ear ossicle element" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "ear ossicle element", "ear ossicles element", "middle ear skeletal element", "ossicle element of ear", "ossicle element of inner ear", "ossicular chain element" ; oboInOwl:id "UBERON:0035130" ; a owl:Class ; rdfs:label "auditory ossicle endochondral element" ; rdfs:subClassOf obo:UBERON_0010363, [ a owl:Restriction ; owl:onProperty obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001756 ], _:genid160946, _:genid160948, _:genid160950 . obo:UBERON_0035131 oboInOwl:hasDbXref "EMAPA:35979" ; oboInOwl:hasExactSynonym "ossicle cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035131" ; a owl:Class ; rdfs:label "auditory ossicle cartilage element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035130 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ] . obo:UBERON_0035132 oboInOwl:hasDbXref "EMAPA:35982" ; oboInOwl:hasExactSynonym "ossicle pre-cartilage condensation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035132" ; a owl:Class ; rdfs:label "auditory ossicle pre-cartilage element" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0035130 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ] . obo:UBERON_0035133 obo:IAO_0000115 "A curved region of the skeleton of the pes (foot) formed by the tarsal and metatarsal bones." ; obo:RO_0002175 obo:NCBITaxon_9780 ; obo:UBPROP_0000012 "in FMA this is modeled as an anatomical line, here we model as an actual subdivision of the skeletal system, containing a row of bones as parts, arranged in a particular configuration" ; oboInOwl:hasDbXref "FMA:75030", "Wikipedia:Arches_of_the_foot" ; oboInOwl:hasExactSynonym "longitudinal arch of foot" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035133" ; a owl:Class ; rdfs:label "longitudinal arch of pes" ; rdfs:subClassOf obo:UBERON_0000075, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0009879 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0010545 ], [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001594 ] . obo:UBERON_0035139 obo:IAO_0000115 "A pointed projection at the front extremity of the intermaxillary suture." ; oboInOwl:hasDbXref "FMA:75770", "Wikipedia:Anterior_nasal_spine" ; oboInOwl:hasExactSynonym "spina nasalis anterior corporis maxillae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior nasal spine" ; oboInOwl:id "UBERON:0035139" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "anterior nasal spine of maxilla" ; rdfs:subClassOf obo:UBERON_0004529, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002397 ] . obo:UBERON_0035159 obo:IAO_0000115 "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface." ; oboInOwl:hasDbXref "FMA:61695", "NCIT:C29667", "SCTID:261060002", "UMLS:C0489451" ; oboInOwl:hasExactSynonym "surface of body" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035159" ; a owl:Class ; rdfs:label "entire surface of organism" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006984 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0035165 obo:IAO_0000115 "The flattened aspect of the prostate with a slight furrow facing the rectum and anus." ; oboInOwl:hasDbXref "FMA:19592", "NCIT:C13095", "SCTID:279697005", "UMLS:C0227961" ; oboInOwl:hasExactSynonym "facies posterior (prostatae)", "facies posterior prostatae", "posterior surface of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035165" ; a owl:Class ; rdfs:label "posterior surface of prostate" ; owl:disjointWith obo:UBERON_0035523 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0035174 obo:IAO_0000115 "The organ of hearing located on the right side of the head." ; oboInOwl:hasDbXref "FMA:53641", "NCIT:C81285", "SCTID:368570004", "UMLS:C0229298" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035174" ; a owl:Class ; rdfs:label "right ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001690 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0035198 obo:IAO_0000115 "The tubules that carry lymph throughout the body that are just beneath the surface of the skin." ; oboInOwl:hasDbXref "FMA:52011", "NCIT:C33663", "SCTID:20315002", "UMLS:C1282745" ; oboInOwl:hasExactSynonym "superficial lymph vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035198" ; a owl:Class ; rdfs:label "superficial lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035549 ] ) ] . obo:UBERON_0035237 oboInOwl:hasDbXref "FMA:70506", "NCIT:C32837", "SCTID:360629008", "UMLS:C1182571" ; oboInOwl:hasExactSynonym "internal carotid arterial subdivision", "subdivision of internal carotid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035237" ; a owl:Class ; rdfs:label "branch of internal carotid artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005396 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001532 ] ) ] . obo:UBERON_0035267 obo:IAO_0000115 "The narrowest portion of the gallbladder and distal to the cystic duct." ; oboInOwl:hasDbXref "FMA:14538", "NCIT:C32649", "SCTID:245394007", "UMLS:C0227546", "Wikipedia:Neck_of_gallbladder" ; oboInOwl:hasExactSynonym "cervix of gallbladder", "gallbladder neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035267" ; a owl:Class ; rdfs:label "neck of gallbladder" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0035295 obo:IAO_0000115 "The organ of hearing located on the left side of the head[ncit,modified]." ; oboInOwl:hasDbXref "FMA:53642", "NCIT:C81259", "SCTID:368592000", "UMLS:C0229299" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035295" ; a owl:Class ; rdfs:label "left ear" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001690 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_0035307 oboInOwl:hasDbXref "FMA:76259", "NCIT:C33867", "SCTID:360535000", "UMLS:C1185372" ; oboInOwl:hasExactSynonym "vertebral arterial branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035307" ; a owl:Class ; rdfs:label "branch of vertebral artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001535 ] ) ] . obo:UBERON_0035313 oboInOwl:hasDbXref "FMA:55063", "NCIT:C12249", "SCTID:276966005", "UMLS:C0227174" ; oboInOwl:hasExactSynonym "posterior wall of hypopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035313" ; a owl:Class ; rdfs:label "posterior wall of laryngopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0001051 ] ) ] . obo:UBERON_0035316 obo:IAO_0000115 "The membrane the surrounds the prostate gland." ; oboInOwl:hasDbXref "FMA:19583", "NCIT:C13086", "SCTID:279682007", "UMLS:C0227963" ; oboInOwl:hasExactSynonym "capsule of prostate", "capsule of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035316" ; a owl:Class ; rdfs:label "prostatic capsule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0035322 oboInOwl:hasDbXref "FMA:14765", "NCIT:C33474", "SCTID:283392005", "UMLS:C0226362" ; oboInOwl:hasExactSynonym "trunk of right common iliac arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035322" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right common iliac artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001191 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0035350 oboInOwl:hasDbXref "FMA:50081", "NCIT:C33114", "SCTID:314302003", "UMLS:C0923405" ; oboInOwl:hasExactSynonym "middle cerebral arterial branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035350" ; a owl:Class ; rdfs:label "branch of middle cerebral artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001627 ] ) ] . obo:UBERON_0035371 obo:IAO_0000115 "A lymph node located in the retroperitoneal space." ; oboInOwl:hasDbXref "FMA:16694", "NCIT:C98189", "SCTID:249613000", "UMLS:C0229802" ; oboInOwl:hasExactSynonym "retroperitoneal node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035371" ; a owl:Class ; rdfs:label "retroperitoneal lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003693 ] ) ] . obo:UBERON_0035383 oboInOwl:hasDbXref "FMA:54908", "NCIT:C12244", "SCTID:361937006", "UMLS:C0225486" ; oboInOwl:hasExactSynonym "lateral nasopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035383" ; a owl:Class ; rdfs:label "lateral wall of nasopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0035398 oboInOwl:hasDbXref "FMA:70505", "NCIT:C32552", "SCTID:244216003", "UMLS:C0447038" ; oboInOwl:hasExactSynonym "external carotid arterial subdivision", "subdivision of external carotid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035398" ; a owl:Class ; rdfs:label "branch of external carotid artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001070 ] ) ] . obo:UBERON_0035401 oboInOwl:hasDbXref "FMA:54907", "NCIT:C12243", "SCTID:361936002", "UMLS:C0225484" ; oboInOwl:hasExactSynonym "posterior nasopharynx" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035401" ; a owl:Class ; rdfs:label "posterior wall of nasopharynx" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ] . obo:UBERON_0035403 obo:IAO_0000115 "An artery that supplies the pituitary gland." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035403" ; a owl:Class ; rdfs:label "hypophysial artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000007 ] ) ] . obo:UBERON_0035431 obo:IAO_0000115 "The parietal pleura that lines the mediastinum." ; oboInOwl:hasDbXref "FMA:9736", "NCIT:C94820", "SCTID:362002008", "UMLS:C0225789", "Wikipedia:Mediastinal_pleura" ; oboInOwl:hasExactSynonym "mediastinal part of parietal pleura", "pars mediastinalis (pleurae)", "pars mediastinalis pleurae parietalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035431" ; a owl:Class ; rdfs:label "mediastinal pleura" ; rdfs:subClassOf obo:UBERON_0034944, _:genid161084, _:genid161086 . obo:UBERON_0035435 obo:IAO_0000115 "A vein that drains blood from the right adrenal gland into the inferior vena cava." ; oboInOwl:hasDbXref "FMA:14343", "NCIT:C53131", "SCTID:69354005", "UMLS:C0226721" ; oboInOwl:hasExactSynonym "vena suprarenalis (adrenalis) dextra" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035435" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "right suprarenal vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001072 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001146 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0035471 oboInOwl:hasDbXref "FMA:15590", "NCIT:C32895", "SCTID:279376000", "UMLS:C0227610" ; oboInOwl:hasExactSynonym "facies posterior (Ren)", "facies posterior renis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035471" ; a owl:Class ; rdfs:label "posterior surface of kidney" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0002113 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002113 ] ) ] . obo:UBERON_0035480 obo:IAO_0000115 "The external portion of the prostate including the anterior, inferolateral, lateral and posterior surfaces." ; oboInOwl:hasDbXref "FMA:19590", "NCIT:C13091", "SCTID:279694003", "UMLS:C0426735" ; oboInOwl:hasExactSynonym "prostatic surface", "surface of prostate gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035480" ; a owl:Class ; rdfs:label "surface of prostate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0035483 obo:IAO_0000115 "A vein that drains blood from the left adrenal gland into the left renal artery." ; oboInOwl:hasDbXref "FMA:14349", "NCIT:C53138", "SCTID:85087001", "UMLS:C0226709", "Wikipedia:Suprarenal_veins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035483" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left suprarenal vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001142 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001146 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0035489 oboInOwl:hasDbXref "FMA:76269", "NCIT:C32195", "SCTID:360537008", "UMLS:C1185381" ; oboInOwl:hasExactSynonym "basilar arterial branch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035489" ; a owl:Class ; rdfs:label "branch of basilar artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001633 ] ) ] . obo:UBERON_0035523 obo:IAO_0000115 "The aspect of the prostate facing the pubic symphysis." ; oboInOwl:hasDbXref "FMA:19591", "NCIT:C13089", "SCTID:279696001", "UMLS:C0227960" ; oboInOwl:hasExactSynonym "anterior surface of prostate gland", "facies anterior (prostatae)", "facies anterior prostatae" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035523" ; a owl:Class ; rdfs:label "anterior surface of prostate" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0036215 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0002367 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002367 ] ) ] . obo:UBERON_0035529 oboInOwl:hasDbXref "FMA:14766", "NCIT:C32957", "SCTID:283493001", "UMLS:C0226363" ; oboInOwl:hasExactSynonym "trunk of left common iliac arterial tree" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035529" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left common iliac artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001191 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_0035539 obo:IAO_0000115 "Any of several arteries that arise from the aorta and supply blood to the esophagus." ; oboInOwl:hasDbXref "FMA:4149", "NCIT:C32535", "SCTID:56548006", "UMLS:C0226294" ; oboInOwl:hasExactSynonym "aortic esophageal artery", "oesophageal artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035539" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "esophageal artery" ; rdfs:subClassOf obo:UBERON_0004573, [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0002345 ], _:genid161146 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ] . obo:UBERON_0035545 obo:IAO_0000115 "The tubules that carry lymph throughout the body that are in the interior of the body or limbs." ; oboInOwl:hasDbXref "FMA:52012", "NCIT:C32439", "SCTID:14033005", "UMLS:C1282746" ; oboInOwl:hasExactSynonym "deep lymph vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035545" ; a owl:Class ; rdfs:label "deep lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] ) ] . obo:UBERON_0035546 oboInOwl:hasDbXref "FMA:51797", "SCTID:149683007" ; oboInOwl:hasExactSynonym "ciliary vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035546" ; a owl:Class ; rdfs:label "uveal vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001768 ] ) ] . obo:UBERON_0035548 oboInOwl:hasDbXref "SCTID:77852007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035548" ; a owl:Class ; rdfs:label "colic artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_0035549 obo:IAO_0000115 "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." ; oboInOwl:hasDbXref "FMA:225275" ; oboInOwl:hasExactSynonym "superficial part of circulatory system", "superficial vasculature" ; oboInOwl:hasNarrowSynonym "dermis vasculature", "hypodermis vasculature" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "skin vasculature", "subcutaneous vasculature", "vasculature of skin" ; oboInOwl:id "UBERON:0035549" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vasculature of integument" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0001659 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002199 ] ) ] . obo:UBERON_0035550 obo:IAO_0000115 "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers." ; oboInOwl:hasDbXref "FMA:76719", "NCIT:C33666", "SCTID:341382008", "UMLS:C0226513", "Wikipedia:Superficial_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "superfical vein", "superficial veins", "superficial vessels" ; oboInOwl:id "UBERON:0035550" ; a owl:Class ; rdfs:label "superficial vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035549 ] ) ] . obo:UBERON_0035551 obo:IAO_0000115 "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin." ; oboInOwl:hasExactSynonym "deep part of circulatory system" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035551" ; a owl:Class ; rdfs:label "deep vasculature" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000107 ; owl:someValuesFrom obo:UBERON_0002199 ] ) ] . obo:UBERON_0035552 obo:IAO_0000115 "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery." ; oboInOwl:hasDbXref "FMA:76718", "NCIT:C32444", "SCTID:341484008", "UMLS:C0226514", "Wikipedia:Deep_vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "deep veins", "deep vessels" ; oboInOwl:id "UBERON:0035552" ; a owl:Class ; rdfs:label "deep vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035551 ] ) ] . obo:UBERON_0035553 obo:IAO_0000115 "Any chamber of the left side of the heart." ; oboInOwl:hasDbXref "FMA:7166", "SCTID:362008007" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035553" ; a owl:Class ; rdfs:label "left cardiac chamber" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid158921 ] . obo:UBERON_0035554 obo:IAO_0000115 "Any chamber of the right side of the heart." ; oboInOwl:hasDbXref "FMA:7165", "SCTID:362007002" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035554" ; a owl:Class ; rdfs:label "right cardiac chamber" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004151 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0035597 obo:IAO_0000115 "An embryonic structure positioned halfway between the prospective eye and ear, adjacent to the future midbrain-hindbrain boundary. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." ; oboInOwl:hasDbXref "XAO:0004093" ; oboInOwl:hasExactSynonym "ophthalmic lobe of trigeminal placode", "ophthalmic lobe of trigeminal placode complex", "ophthalmic placode", "profundus placode" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035597" ; a owl:Class ; rdfs:label "profundal placode" ; rdfs:subClassOf obo:UBERON_0009955, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003070 ] . obo:UBERON_0035606 oboInOwl:hasDbXref "FMA:61298" ; oboInOwl:hasExactSynonym "cartilage of acoustic meatus", "cartilage of auditory canal", "cartilago meatus acustici", "external acoustic meatus cartilage" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035606" ; a owl:Class ; rdfs:label "cartilage of external acoustic meatus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001352 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001867 ] ) ] . obo:UBERON_0035608 obo:IAO_0000115 "Any lymph vessel that is located in the dura mater of the brain." ; obo:UBPROP_0000010 "while Louveau et al (DOI:10.1038/nature14432) state this is within the CNS (thus overturning dogma about the presence of lymphatics in the CNS), in this ontology the dura" ; oboInOwl:hasExactSynonym "dural lymph vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "dural lymph vasculature" ; oboInOwl:id "UBERON:0035608" ; a owl:Class ; rdfs:comment "Louveau et al (DOI:10.1038/nature14432) claim the discovery of lymphatics in the cerebral dura mater, but this is disputed by Bucchieri et al (DOI:10.1111/joa.12381)" ; rdfs:label "dura mater lymph vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010743 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid158947 ] . obo:UBERON_0035639 obo:IAO_0000115 "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." ; oboInOwl:hasDbXref "FMA:76554", "NCIT:C32574", "SCTID:120612006", "UMLS:C0229243", "Wikipedia:Accessory_visual_structures" ; oboInOwl:hasExactSynonym "adnexa oculi" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "accessory parts of orbital region", "accessory visual structures", "accessory visual structures set", "adnexal parts of orbital region", "appendage of eye", "appendages of the eye", "eye adnexa", "set of accessory visual structures", "structurae oculi accessoriae" ; oboInOwl:id "UBERON:0035639" ; a owl:Class ; rdfs:label "ocular adnexa" ; rdfs:subClassOf obo:UBERON_0034921, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] . obo:UBERON_0035642 obo:IAO_0000115 "Any nerve that innervates the larynx." ; oboInOwl:hasDbXref "MESH:D007823", "SCTID:307013006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035642" ; a owl:Class ; rdfs:label "laryngeal nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001737 ] ) ] . obo:UBERON_0035648 obo:IAO_0000115 "Any nerve that innervates the pinna." ; oboInOwl:hasDbXref "EMAPA:36513", "MA:0001232" ; oboInOwl:hasExactSynonym "auricular nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035648" ; a owl:Class ; rdfs:label "nerve innervating pinna" ; rdfs:subClassOf _:genid161243 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001757 ] ) ] . obo:UBERON_0035649 obo:IAO_0000115 "Any nerve that innervates the penis." ; oboInOwl:hasDbXref "EMAPA:35057" ; oboInOwl:hasExactSynonym "penile nerve", "penis nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035649" ; a owl:Class ; rdfs:label "nerve of penis" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0035650 obo:IAO_0000115 "Any nerve that innervates the clitoris." ; oboInOwl:hasDbXref "EMAPA:35044" ; oboInOwl:hasExactSynonym "clitoral nerve", "clitoris nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035650" ; a owl:Class ; rdfs:label "nerve of clitoris" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0002411 ] ) ] . obo:UBERON_0035651 oboInOwl:hasDbXref "Wikipedia:Glans" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035651" ; a owl:Class ; rdfs:label "glans" ; rdfs:subClassOf obo:UBERON_0000063, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003133 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013238 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0001299 obo:UBERON_0006653 ) ] . obo:UBERON_0035652 obo:IAO_0000115 "Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches." ; oboInOwl:hasDbXref "EMAPA:36511", "MESH:D010543" ; oboInOwl:hasExactSynonym "peroneal nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035652" ; oboInOwl:inSubset core:grouping_class ; a owl:Class ; rdfs:label "fibular nerve" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0009132 ] ) ] . obo:UBERON_0035662 oboInOwl:hasDbXref "FMA:50919" ; oboInOwl:hasExactSynonym "anterior parotid vein", "parotid branch of facial vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035662" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "parotid vein" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001653 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001831 ] ) ] . obo:UBERON_0035763 oboInOwl:hasDbXref "EHDAA2:0004181", "FMA:9464" ; oboInOwl:hasExactSynonym "cardiac chamber cavity", "heart cavity", "heart lumen" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035763" ; a owl:Class ; rdfs:label "cavity of cardiac chamber" ; rdfs:subClassOf _:genid161278 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0004151 ] ) ] . obo:UBERON_0035764 oboInOwl:hasDbXref "FMA:5968" ; oboInOwl:hasExactSynonym "intrapulmonary lymph node", "pulmonary node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035764" ; a owl:Class ; rdfs:label "pulmonary lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008886 ] ) ] . obo:UBERON_0035767 oboInOwl:hasDbXref "FMA:223208", "NCIT:C12930", "UMLS:C1512970" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035767" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "intrapulmonary bronchus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002185 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ] . obo:UBERON_0035776 obo:IAO_0000115 "A parasympathetic ganglion located on the short ciliary nerve differentiated from the main ciliary ganglion by virtue of the fact that it had no root derived directly from the inferior trunk of the oculomotor nerve and it never attaches to this nerve." ; obo:RO_0002171 obo:UBERON_0001643 ; obo:UBPROP_0000008 "tested for and found to be present in pig, sika deer, domestic sheep, horse, cat, fox, racoon dog, marten, rat, rabbit, crab-eating macaque, japanese macaque and human[PMID:2802184]" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035776" ; a owl:Class ; rdfs:label "accessory ciliary ganglion" ; rdfs:subClassOf obo:UBERON_0001808, [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0022302 ], _:genid161293 . obo:UBERON_0035783 obo:IAO_0000115 "Any parasympathetic ganglion that extends fibers into the short ciliary nerve. Includes both the main and acccessory ciliary ganglia." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035783" ; a owl:Class ; rdfs:label "ganglion of ciliary nerve" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004088 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001808 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0022302 ] ) ], [ a owl:Class ; owl:unionOf (obo:UBERON_0002058 obo:UBERON_0035776 ) ] . obo:UBERON_0035784 obo:IAO_0000115 "A portion of semen in a coagulated state." ; oboInOwl:hasExactSynonym "seminal coagulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035784" ; a owl:Class ; rdfs:label "seminal clot" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001968 [ a owl:Restriction ; owl:onProperty obo:RO_0002353 ; owl:someValuesFrom obo:GO_0050817 ] ) ] . obo:UBERON_0035804 obo:IAO_0000115 "The primordial mouth region of the developing head." ; oboInOwl:hasDbXref "FMA:293105" ; oboInOwl:hasExactSynonym "primitive mouth", "primordial mouth" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035804" ; a owl:Class ; rdfs:label "future mouth" ; rdfs:subClassOf obo:UBERON_0013522, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007026 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000925 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000930 ] . obo:UBERON_0035805 obo:IAO_0000115 "A muscle layer that is part of the sigmoid colon." ; oboInOwl:hasDbXref "FMA:15028" ; oboInOwl:hasExactSynonym "muscularis externa of sigmoid colon", "muscularis propria of sigmoid colon", "sigmoid colon muscularis propria" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "sigmoideum muscularis", "tunica muscularis colon sigmoideum" ; oboInOwl:id "UBERON:0035805" ; a owl:Class ; rdfs:label "muscle layer of sigmoid colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_0035809 oboInOwl:hasDbXref "FMA:12241", "SCTID:304404008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035809" ; a owl:Class ; rdfs:label "serous cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002553 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0005906 ] ) ] . obo:UBERON_0035814 obo:IAO_0000115 "The sum of epicardial and paracardial fat deposits." ; oboInOwl:hasDbXref "SCTID:42267001", "ZFA:0005765" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035814" ; a owl:Class ; rdfs:label "pericardial fat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0035815 obo:IAO_0000115 "Fat deposits in the mediastinum outside the parietal pericardium ." ; oboInOwl:hasExactSynonym "intrathoracic fat" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035815" ; a owl:Class ; rdfs:label "paracardial fat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002408 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0035818 obo:IAO_0000115 "Any fat deposit surrounding a visceral organ." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035818" ; a owl:Class ; rdfs:label "visceral fat" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001013 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000062 ] ) ] . obo:UBERON_0035819 obo:IAO_0000115 "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity." ; oboInOwl:hasDbXref "FMA:12267", "Wikipedia:Abdominopelvic_cavity" ; oboInOwl:hasExactSynonym "cavitas abdominis et pelvis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035819" ; a owl:Class ; rdfs:label "abdominopelvic cavity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002323 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002417 ] ) ] . obo:UBERON_0035820 obo:IAO_0000115 "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." ; oboInOwl:hasDbXref "EMAPA:16137", "FMA:9908" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "peritoneal component" ; oboInOwl:id "UBERON:0035820" ; a owl:Class ; rdfs:label "peritoneal sac" ; rdfs:subClassOf obo:UBERON_0005906, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001179 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002358 ], [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003684 ] . obo:UBERON_0035825 obo:IAO_0000115 "The thick outer layer of the adrenal gland that is in the left side of the abdomen." ; oboInOwl:hasDbXref "FMA:69089" ; oboInOwl:hasExactSynonym "cortex of left adrenal gland", "cortex of left suprarenal gland", "left adrenal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035825" ; a owl:Class ; rdfs:label "left adrenal gland cortex" ; rdfs:subClassOf obo:UBERON_0001235 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001234 ] ) ] . obo:UBERON_0035826 obo:IAO_0000115 "The adrenal gland medulla that is in the left side of the abdomen." ; oboInOwl:hasDbXref "FMA:69092" ; oboInOwl:hasExactSynonym "left adrenal medulla", "medulla of left adrenal gland", "medulla of left suprarenal gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035826" ; a owl:Class ; rdfs:label "left adrenal gland medulla" ; rdfs:subClassOf obo:UBERON_0001236 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001234 ] ) ] . obo:UBERON_0035827 obo:IAO_0000115 "The thick outer layer of the adrenal gland that is in the right side of the abdomen." ; oboInOwl:hasDbXref "FMA:69088" ; oboInOwl:hasExactSynonym "cortex of right adrenal gland", "cortex of right suprarenal gland", "right adrenal cortex" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035827" ; a owl:Class ; rdfs:label "right adrenal gland cortex" ; rdfs:subClassOf obo:UBERON_0001235 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001851 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001233 ] ) ] . obo:UBERON_0035828 obo:IAO_0000115 "The adrenal gland medulla that is in the right side of the abdomen." ; oboInOwl:hasDbXref "FMA:69091" ; oboInOwl:hasExactSynonym "medulla of right adrenal gland", "medulla of right suprarenal gland", "right adrenal medulla" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035828" ; a owl:Class ; rdfs:label "right adrenal gland medulla" ; rdfs:subClassOf obo:UBERON_0001236 ; owl:equivalentClass _:genid159109 . obo:UBERON_0035849 obo:IAO_0000115 "The mostly sharp edge of the orbital opening that is the peripheral border of the base of the pyramidal orbit." ; oboInOwl:hasDbXref "FMA:53176", "SCTID:362641009" ; oboInOwl:hasExactSynonym "margin of orbit", "margo orbitalis", "orbital rim" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035849" ; a owl:Class ; rdfs:label "orbital margin" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001697 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0004867 ] . obo:UBERON_0035879 obo:IAO_0000115 "A suture between the frontal bone and the frontal process of the maxilla." ; oboInOwl:hasDbXref "FMA:52950" ; oboInOwl:hasExactSynonym "frontomaxillary suture of skull", "sutura frontomaxillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035879" ; a owl:Class ; rdfs:label "frontomaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000209 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013767 ] ) ] . obo:UBERON_0035881 obo:IAO_0000115 "A suture between the orbital surface of the body of the maxilla with the orbital plate of the ethmoid bone." ; oboInOwl:hasDbXref "FMA:52954" ; oboInOwl:hasExactSynonym "ethmoidomaxillary suture of skull", "sutura ethmoidomaxillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035881" ; a owl:Class ; rdfs:label "ethmoidomaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_0035882 obo:IAO_0000115 "An inconstant suture between the pterygoid process of the sphenoid bone and the body of the maxilla." ; oboInOwl:hasDbXref "FMA:52957" ; oboInOwl:hasExactSynonym "sphenomaxillary suture of skull", "sutura sphenomaxillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035882" ; a owl:Class ; rdfs:label "sphenomaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004649 ] ) ] . obo:UBERON_0035883 obo:IAO_0000115 "A suture between the lacrimal bone and the maxilla." ; oboInOwl:hasDbXref "FMA:52961" ; oboInOwl:hasExactSynonym "lacrimomaxillary suture of skull", "sutura lacrimomaxillaris" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035883" ; a owl:Class ; rdfs:label "lacrimomaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001680 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_0035884 obo:IAO_0000115 "A suture between the maxilla and premaxilla." ; obo:UBPROP_0000008 "present in mouse [PMID:21538817]", "transient in humans" ; oboInOwl:hasExactSynonym "maxillary-premaxillary incisive suture" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "incisive suture", "premaxillary suture" ; oboInOwl:id "UBERON:0035884" ; a owl:Class ; rdfs:label "maxillary-premaxillary suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_0035927 oboInOwl:hasDbXref "HBA:9370", "SCTID:314145001" ; oboInOwl:hasExactSynonym "parietal lobe sulci", "parietal lobe sulcus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "PLs" ; oboInOwl:id "UBERON:0035927" ; a owl:Class ; rdfs:label "sulcus of parietal lobe" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0013118 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001872 ] ) ] . obo:UBERON_0035956 obo:IAO_0000115 "The lumen of the epididymis." ; oboInOwl:hasDbXref "FMA:18274", "SCTID:367722009" ; oboInOwl:hasExactSynonym "epididymis lumen", "lumen of epididymis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0035956" ; a owl:Class ; rdfs:label "epididymal lumen" ; rdfs:subClassOf _:genid161456 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001301 ] ) ] . obo:UBERON_0035965 oboInOwl:hasDbXref "BTO:0004378", "EMAPA:37987", "FMA:67473" ; oboInOwl:hasExactSynonym "blood vessel wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vascular wall" ; oboInOwl:id "UBERON:0035965" ; a owl:Class ; rdfs:label "wall of blood vessel" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0004797 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001981 ] ) ] . obo:UBERON_0036013 obo:IAO_0000115 "The line that divided the gluteal regions of the body." ; oboInOwl:hasDbXref "FMA:20234" ; oboInOwl:hasExactSynonym "anal cleft", "crena analis", "crena ani", "crena interglutealis", "intergluteal crease", "natal cleft" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036013" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:label "intergluteal cleft" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013691 ] ; owl:equivalentClass _:genid161469 . obo:UBERON_0036014 obo:IAO_0000115 "A horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg." ; obo:RO_0002175 obo:NCBITaxon_9604 ; oboInOwl:hasDbXref "FMA:20233", "SCTID:362679004", "Wikipedia:Gluteal_sulcus" ; oboInOwl:hasExactSynonym "gluteal fold", "sulcus glutealis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "gluteal crease", "horizontal gluteal crease" ; oboInOwl:id "UBERON:0036014" ; oboInOwl:inSubset core:pheno_slim ; a owl:Class ; rdfs:comment "Children with developmental dysplasia of the hips are born with uneven gluteal folds and can be diagnosed with physical examination and sonogram" ; rdfs:label "gluteal sulcus" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0002103 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0013691 ] ) ] . obo:UBERON_0036072 oboInOwl:hasDbXref "EHDAA2:0004070" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036072" ; a owl:Class ; rdfs:label "respiratory primordium epithelium" ; rdfs:subClassOf _:genid161501 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008947 ] ) ] . obo:UBERON_0036073 oboInOwl:hasDbXref "EHDAA2:0004071" ; oboInOwl:hasExactSynonym "respiratory primordium associated mesenchyme" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036073" ; a owl:Class ; rdfs:label "respiratory primordium mesenchyme" ; rdfs:subClassOf _:genid161507 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008947 ] ) ] . obo:UBERON_0036074 obo:IAO_0000115 "A vein that leaves the vestibule through an individual bone canal running parallel to the vestibular aqueduct up to the dura of the posterior side of the petrosa in the area of the endolymphatic sac. It then opens in the inferior petrosal sinus or the jugular bulb. The vein receives other branches from the bone, dura and sac." ; oboInOwl:hasDbXref "FMA:52367" ; oboInOwl:hasExactSynonym "vena aqueductus vestibuli", "vestibular aqueduct vein" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036074" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "vein of vestibular aqueduct" ; rdfs:subClassOf obo:UBERON_0001638, _:genid161510, _:genid161512, _:genid161514 . obo:UBERON_0036146 obo:IAO_0000115 "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036146" ; a owl:Class ; rdfs:label "cardiopharyngeal field" ; rdfs:subClassOf obo:UBERON_0007688, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] . obo:UBERON_0036150 obo:IAO_0000115 "An organ subunit in the skin that gives rise to cutaneous appendage." ; oboInOwl:hasBroadSynonym "follicle" ; oboInOwl:hasExactSynonym "cutaneous appendage follicle", "skin follicle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036150" ; a owl:Class ; rdfs:label "skin appendage follicle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000014 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001003 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002067 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000021 ] ) ] . obo:UBERON_0036186 oboInOwl:hasDbXref "FMA:83520" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036186" ; a owl:Class ; rdfs:label "fibroelastic connective tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011824 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0071953 ] ) ] . obo:UBERON_0036212 obo:IAO_0000115 "A surface structure that is the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by theantitragus, and along its lower lateral margins and inferior boundary by the connection between the first two." ; oboInOwl:hasBroadSynonym "incisura" ; oboInOwl:hasDbXref "FMA:61175", "SCTID:362542005", "Wikipedia:Incisura_anterior_auris" ; oboInOwl:hasExactSynonym "incisura intertragica", "intertragal incisure", "intertragic incisure", "intertragic notch" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anterior auricular groove", "auricular notch", "incisura anterior auris", "intertragic incisure", "sulcus auriculae anterior" ; oboInOwl:id "UBERON:0036212" ; a owl:Class ; rdfs:comment "Measurement notes: The length is measured from the upper to the lower border (between tragus and antitragus)" ; rdfs:label "intertragic incisure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006846 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0010887 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0016467 ] ) ] . obo:UBERON_0036214 obo:IAO_0000115 "An anatomical junction that is between the sigmoid colon and rectum." ; oboInOwl:hasDbXref "NCIT:C54188", "SCTID:245429006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "rectosigmoid region" ; oboInOwl:id "UBERON:0036214" ; a owl:Class ; rdfs:label "rectosigmoid junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_0036215 obo:IAO_0000115 "Material anatomical entity that forms the outermost boundary of an anatomical structure." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasDbXref "AAO:0010270", "AEO:0000154", "ZFA:0005594" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036215" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical surface region" ; rdfs:subClassOf obo:UBERON_0000465, [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000061 ] . obo:UBERON_0036217 obo:IAO_0000115 "A bodily fluid that is located in the coelom." ; obo:UBPROP_0000009 "he coelomic fluid serves several functions; it acts as a hydroskeleton, it allows free movement and growth of internal organs, it serves for transport of gases, nutrients and waste products between different parts of the body, it allows storage of sperm and eggs during maturation and it acts as a reservoir for waste [Wikipedia:Coelom#Coelomic_fluid]" ; oboInOwl:hasDbXref "BTO:0001708" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036217" ; a owl:Class ; rdfs:label "coelomic fluid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006314 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0011997 ] ) ] . obo:UBERON_0036224 obo:IAO_0000115 "The corticobulbar and corticospinal tracts combined." ; oboInOwl:hasBroadSynonym "pyramidal tract" ; oboInOwl:hasDbXref "Wikipedia:Pyramidal_tracts" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036224" ; a owl:Class ; rdfs:label "corticobulbar and corticospinal tracts" ; rdfs:subClassOf obo:UBERON_0001018, _:genid161572 . obo:UBERON_0036225 obo:IAO_0000115 "Any gland that is part os the respiratory system." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036225" ; a owl:Class ; rdfs:label "respiratory system gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002530 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ] . obo:UBERON_0036242 obo:IAO_0000115 "A notochord that has persisted beyond the embryonic stage." ; obo:RO_0002175 obo:NCBITaxon_7746, obo:NCBITaxon_7878 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036242" ; a owl:Class ; rdfs:label "post-embryonic notochord" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002328 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009953 ] ) ] . obo:UBERON_0036243 obo:IAO_0000115 "Fluid that lines the vaginal walls that consists of multiple secretions that collect in the vagina from different glands." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "vaginal discharge", "vaginal secretion" ; oboInOwl:id "UBERON:0036243" ; a owl:Class ; rdfs:label "vaginal fluid" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006314 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0036244 obo:IAO_0000115 "A transudate found in the serous sac." ; oboInOwl:hasBroadSynonym "serous fluid" ; oboInOwl:hasDbXref "FMA:20932" ; oboInOwl:hasExactSynonym "serous sac fluid" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036244" ; a owl:Class ; rdfs:label "secretion of serous membrane" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005906 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007779 [ a owl:Restriction ; owl:onProperty core:filtered_through ; owl:someValuesFrom obo:UBERON_0000042 ] ) ] . obo:UBERON_0036245 obo:IAO_0000115 "Parenchymal tissue that consists of the alveoli, grape-like clusters where milk is stored, and branching ducts, which are tubular canals carrying gladular secretions." ; oboInOwl:hasExactSynonym "lactiferous gland parenchyma", "mammary gland parenchyma", "parenchyma of lactiferous gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036245" ; a owl:Class ; rdfs:label "parenchyma of mammary gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) ] . obo:UBERON_0036246 obo:IAO_0000115 "The small synovial joint connecting the inclus and the stapes, located between the lenticular process on the long crus of the incus and the head of the stapes." ; oboInOwl:hasDbXref "FMA:60065" ; oboInOwl:hasExactSynonym "articulatio incudostapedialis", "incudostapedial articulation" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036246" ; a owl:Class ; rdfs:label "incudostapedial joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015016 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015017 ] ) ] . obo:UBERON_0036247 obo:IAO_0000115 "The saddle-shaped synovial joint connecting the incus and the malleus." ; oboInOwl:hasDbXref "FMA:60064" ; oboInOwl:hasExactSynonym "articulatio incudomallearis", "incudomallear articulation", "incudomalleolar joint" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036247" ; a owl:Class ; rdfs:label "incudomallear joint" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015017 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0015018 ] ) ] . obo:UBERON_0036248 obo:IAO_0000115 "Any synovial joint that connects auditory ossicles." ; oboInOwl:hasDbXref "FMA:60063" ; oboInOwl:hasExactSynonym "auditory ossicle joint", "auditory ossicles joint", "joint of auditory ossicles" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036248" ; a owl:Class ; rdfs:label "joint of auditory ossicle" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0035130 ] ) ] . obo:UBERON_0036253 oboInOwl:hasDbXref "FMA:53133" ; oboInOwl:hasExactSynonym "cranial orifice", "skull orifice" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036253" ; a owl:Class ; rdfs:label "orifice of skull" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000161 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) ] . obo:UBERON_0036262 obo:IAO_0000115 "Any of the eight ligaments pertaining to the uterus including the anterior, posterior, lateral, sacro-uterine and round ligaments." ; oboInOwl:hasDbXref "NCIT:C61360", "SCTID:272668006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036262" ; a owl:Class ; rdfs:label "uterine ligament" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000211 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ] . obo:UBERON_0036264 obo:IAO_0000115 "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit." ; oboInOwl:hasDbXref "FMA:52972", "SCTID:280243001", "Wikipedia:Zygomaticotemporal_nerve" ; oboInOwl:hasExactSynonym "ramus zygomaticotemporalis (Nervus zygomaticus)", "ramus zygomaticotemporalis nervus zygomatici", "zygomaticotemporal branch of zygomatic nerve" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "zygomaticotemporal", "zygomaticotemporal branch" ; oboInOwl:id "UBERON:0036264" ; a owl:Class ; rdfs:label "zygomaticotemporal nerve" ; rdfs:subClassOf obo:UBERON_0001021, [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000377 ] . obo:UBERON_0036267 oboInOwl:hasDbXref "SCTID:279975006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036267" ; a owl:Class ; rdfs:label "vulval vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000997 ] ) ] . obo:UBERON_0036268 oboInOwl:hasDbXref "SCTID:13152008" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036268" ; a owl:Class ; rdfs:label "pelvic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002355 ] ) ] . obo:UBERON_0036269 oboInOwl:hasDbXref "EMAPA:30807", "SCTID:363673006" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "penis vasculature", "vasculature of penis" ; oboInOwl:id "UBERON:0036269" ; a owl:Class ; rdfs:label "penis blood vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0000989 ] ) ] . obo:UBERON_0036285 obo:IAO_0000115 "Wall of ventricle which is continuous with the wall of aorta." ; oboInOwl:hasDbXref "FMA:9556" ; oboInOwl:hasExactSynonym "left ventricular wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036285" ; a owl:Class ; rdfs:label "wall of left ventricle" ; rdfs:subClassOf obo:UBERON_0004784, _:genid161666 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004784 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0036286 obo:IAO_0000115 "Wall of ventricle which is continuous with the wall of pulmonary trunk." ; oboInOwl:hasDbXref "FMA:9533" ; oboInOwl:hasExactSynonym "right ventricular wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036286" ; a owl:Class ; rdfs:label "wall of right ventricle" ; rdfs:subClassOf obo:UBERON_0004784, _:genid161675 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004784 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0036288 oboInOwl:hasDbXref "FMA:9560" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036288" ; a owl:Class ; rdfs:label "anterior wall of left ventricle" ; rdfs:subClassOf _:genid161683 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004784 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ] . obo:UBERON_0036289 obo:IAO_0000115 "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle." ; oboInOwl:hasDbXref "FMA:9553" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036289" ; a owl:Class ; rdfs:label "anterior wall of right ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004784 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0002080 ] ) ] . obo:UBERON_0036290 oboInOwl:hasDbXref "FMA:87177" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036290" ; a owl:Class ; rdfs:label "myocardium of anterior wall of left ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036288 ] ) ] . obo:UBERON_0036291 oboInOwl:hasDbXref "FMA:260877" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036291" ; a owl:Class ; rdfs:label "myocardium of anterior wall of right ventricle" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002349 _:genid159409 ) ] . obo:UBERON_0036293 obo:IAO_0000115 "A small fold of mucous membrane in the mouth, connecting either the tongue or the lip to the mouth mucosa." ; oboInOwl:hasBroadSynonym "frenulum" ; oboInOwl:hasDbXref "SCTID:303771008" ; oboInOwl:hasExactSynonym "oral frenula", "oral frenulum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "oral frenum" ; oboInOwl:id "UBERON:0036293" ; a owl:Class ; rdfs:label "oral frenulum" ; rdfs:subClassOf obo:UBERON_0000344, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 ] ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0006689 obo:UBERON_0016910 ) ] . obo:UBERON_0036294 obo:IAO_0000115 "A mucosa that is part of a lip region [Automatically generated definition]." ; oboInOwl:hasDbXref "NCIT:C12226" ; oboInOwl:hasExactSynonym "labial mucosa" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036294" ; a owl:Class ; rdfs:label "mucosa of lip" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001833 ] ) ] . obo:UBERON_0036295 obo:IAO_0000115 "The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra." ; oboInOwl:hasDbXref "NCIT:C54419" ; oboInOwl:hasExactSynonym "renal pelvis and ureter", "renal pelvis plus ureter" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036295" ; a owl:Class ; rdfs:label "renal pelvis/ureter" ; rdfs:subClassOf obo:UBERON_0000477, _:genid161711 . obo:UBERON_0036301 oboInOwl:hasDbXref "FMA:225251", "SCTID:297287005" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036301" ; a owl:Class ; rdfs:label "vasculature of spleen" ; rdfs:subClassOf obo:UBERON_0006876 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_0036302 oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036302" ; a owl:Class ; rdfs:label "vasculature of central nervous system plus retina" ; rdfs:subClassOf obo:UBERON_0002049 ; owl:equivalentClass [ a owl:Class ; owl:unionOf (obo:UBERON_0004864 obo:UBERON_0036303 ) ] . obo:UBERON_0036303 oboInOwl:hasDbXref "FMA:259905" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036303" ; a owl:Class ; rdfs:label "vasculature of central nervous system" ; rdfs:subClassOf obo:UBERON_0036302 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 ] ) ] . obo:UBERON_0036304 obo:IAO_0000115 "An anatomical structure that is located along the line dividing two regions of an anatomical structure." ; obo:RO_0002175 obo:NCBITaxon_33090 ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036304" ; oboInOwl:inSubset core:common_anatomy ; a owl:Class ; rdfs:label "anatomical border" ; rdfs:subClassOf obo:UBERON_0000061 . obo:UBERON_0036328 oboInOwl:hasDbXref "FMA:14179" ; oboInOwl:hasExactSynonym "coronary arterial wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036328" ; a owl:Class ; rdfs:label "wall of coronary artery" ; rdfs:subClassOf obo:UBERON_0000415, _:genid161732 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 ] ) ] . obo:UBERON_0036343 oboInOwl:hasDbXref "FMA:14657" ; oboInOwl:hasExactSynonym "gallbladder wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036343" ; a owl:Class ; rdfs:label "wall of gallbladder" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161740 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 ] ) ] . obo:UBERON_0036351 oboInOwl:hasDbXref "FMA:15089" ; oboInOwl:hasExactSynonym "brachiocephalic arterial wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036351" ; a owl:Class ; rdfs:label "wall of brachiocephalic artery" ; rdfs:subClassOf obo:UBERON_0000415, _:genid161748 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001529 ] ) ] . obo:UBERON_0036352 oboInOwl:hasDbXref "FMA:15090" ; oboInOwl:hasExactSynonym "subclavian arterial wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036352" ; a owl:Class ; rdfs:label "wall of subclavian artery" ; rdfs:subClassOf obo:UBERON_0000415, _:genid161756 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 ] ) ] . obo:UBERON_0036362 oboInOwl:hasDbXref "FMA:15704" ; oboInOwl:hasExactSynonym "anal canal wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036362" ; a owl:Class ; rdfs:label "wall of anal canal" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161766, _:genid161768 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 ] ) ] . obo:UBERON_0036375 oboInOwl:hasDbXref "FMA:15889" ; oboInOwl:hasExactSynonym "right ureteral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036375" ; a owl:Class ; rdfs:label "wall of right ureter" ; rdfs:subClassOf obo:UBERON_0009916, _:genid161776 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001222 ] ) ] . obo:UBERON_0036376 oboInOwl:hasDbXref "FMA:15890" ; oboInOwl:hasExactSynonym "left ureteral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036376" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "wall of left ureter" ; rdfs:subClassOf obo:UBERON_0009916, _:genid161784 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001223 ] ) ] . obo:UBERON_0036422 oboInOwl:hasDbXref "FMA:18211" ; oboInOwl:hasExactSynonym "pulmonary arterial wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036422" ; a owl:Class ; rdfs:label "wall of pulmonary artery" ; rdfs:subClassOf obo:UBERON_0000415, _:genid161792 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 ] ) ] . obo:UBERON_0036441 oboInOwl:hasDbXref "FMA:18303" ; oboInOwl:hasExactSynonym "uterine tube wall", "wall of fallopian tube", "wall of oviduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036441" ; a owl:Class ; rdfs:label "wall of uterine tube" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161800 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_0036521 oboInOwl:hasDbXref "FMA:19779" ; oboInOwl:hasExactSynonym "urethral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036521" ; a owl:Class ; rdfs:label "wall of urethra" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161810 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0036523 oboInOwl:hasDbXref "FMA:19971" ; oboInOwl:hasExactSynonym "vaginal wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036523" ; a owl:Class ; rdfs:label "wall of vagina" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161818 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ] . obo:UBERON_0036553 oboInOwl:hasDbXref "FMA:231590" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036553" ; a owl:Class ; rdfs:label "wall of synovial tendon sheath" ; rdfs:subClassOf obo:UBERON_0000042, _:genid161826 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000304 ] ) ] . obo:UBERON_0036654 oboInOwl:hasDbXref "FMA:242772" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036654" ; a owl:Class ; rdfs:label "wall of lateral ventricle" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161833 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 ] ) ] . obo:UBERON_0036655 oboInOwl:hasDbXref "FMA:242774" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036655" ; a owl:Class ; rdfs:label "wall of cerebral aqueduct" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161840 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002289 ] ) ] . obo:UBERON_0036656 oboInOwl:hasDbXref "FMA:242776" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036656" ; a owl:Class ; rdfs:label "wall of third ventricle" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161847 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 ] ) ] . obo:UBERON_0036657 oboInOwl:hasDbXref "FMA:242778" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036657" ; a owl:Class ; rdfs:label "wall of fourth ventricle" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161854 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) ] . obo:UBERON_0036658 oboInOwl:hasDbXref "FMA:242780" ; oboInOwl:hasExactSynonym "wall of central canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036658" ; a owl:Class ; rdfs:label "wall of central canal of spinal cord" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161861 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002291 ] ) ] . obo:UBERON_0036661 oboInOwl:hasDbXref "FMA:242841" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036661" ; a owl:Class ; rdfs:label "wall of ventricular system of brain" ; rdfs:subClassOf obo:UBERON_0005358, _:genid161869 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005282 ] ) ] . obo:UBERON_0036925 oboInOwl:hasDbXref "FMA:58098" ; oboInOwl:hasExactSynonym "eyeball wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036925" ; a owl:Class ; rdfs:label "wall of eyeball" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161876 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 ] ) ] . obo:UBERON_0036990 oboInOwl:hasDbXref "FMA:60069" ; oboInOwl:hasExactSynonym "pharyngotympanic tube wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0036990" ; a owl:Class ; rdfs:label "wall of pharyngotympanic tube" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161884 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 ] ) ] . obo:UBERON_0037089 oboInOwl:hasDbXref "FMA:63144" ; oboInOwl:hasExactSynonym "orbit wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037089" ; a owl:Class ; rdfs:label "wall of orbit" ; rdfs:subClassOf obo:UBERON_0000075, _:genid161892 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001697 ] ) ] . obo:UBERON_0037094 oboInOwl:hasDbXref "FMA:66284" ; oboInOwl:hasExactSynonym "common carotid arterial wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037094" ; a owl:Class ; rdfs:label "wall of common carotid artery" ; rdfs:subClassOf obo:UBERON_0000415, _:genid161900 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001530 ] ) ] . obo:UBERON_0037144 obo:IAO_0000115 "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." ; oboInOwl:hasDbXref "FMA:7274" ; oboInOwl:hasExactSynonym "cardiac wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037144" ; a owl:Class ; rdfs:label "wall of heart" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161908, _:genid161910, _:genid161912 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 ] ) ] . obo:UBERON_0037191 oboInOwl:hasDbXref "FMA:79837" ; oboInOwl:hasExactSynonym "membranous labyrinth wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037191" ; a owl:Class ; rdfs:label "wall of membranous labyrinth" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161921 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001849 ] ) ] . obo:UBERON_0037237 oboInOwl:hasDbXref "FMA:85375" ; oboInOwl:hasExactSynonym "lacrimal ductal wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037237" ; a owl:Class ; rdfs:label "wall of lacrimal duct" ; rdfs:subClassOf obo:UBERON_0000060, _:genid161929 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 ] ) ] . obo:UBERON_0037447 oboInOwl:hasDbXref "FMA:19676" ; oboInOwl:hasExactSynonym "male urethral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037447" ; a owl:Class ; rdfs:label "wall of male urethra" ; rdfs:subClassOf obo:UBERON_0036521, _:genid161937 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 ] ) ] . obo:UBERON_0037455 oboInOwl:hasDbXref "FMA:19780" ; oboInOwl:hasExactSynonym "female urethral wall" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037455" ; a owl:Class ; rdfs:label "wall of female urethra" ; rdfs:subClassOf obo:UBERON_0036521, _:genid161945 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000060 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 ] ) ] . obo:UBERON_0037458 oboInOwl:hasDbXref "FMA:54242" ; oboInOwl:hasExactSynonym "neck hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037458" ; a owl:Class ; rdfs:label "hair of neck" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974 ] ) ] . obo:UBERON_0037459 oboInOwl:hasDbXref "FMA:54243" ; oboInOwl:hasExactSynonym "limb hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0037459" ; a owl:Class ; rdfs:label "hair of limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_0039175 oboInOwl:hasDbXref "FMA:322073" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039175" ; a owl:Class ; rdfs:label "subarachnoid space of brain" ; rdfs:subClassOf obo:UBERON_0000315 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_0039176 oboInOwl:hasDbXref "FMA:322074" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039176" ; a owl:Class ; rdfs:label "subarachnoid space of spinal cord" ; rdfs:subClassOf obo:UBERON_0000315 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000315 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 ] ) ] . obo:UBERON_0039222 obo:IAO_0000115 "An artery that supplies oxygenated blood to the cystic duct." ; oboInOwl:hasDbXref "FMA:14835" ; oboInOwl:hasExactSynonym "cholecystic artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039222" ; a owl:Class ; rdfs:label "cystic artery" ; rdfs:subClassOf _:genid161972 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001152 ] ) ] . obo:UBERON_0039228 oboInOwl:hasDbXref "FMA:15395" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039228" ; a owl:Class ; rdfs:label "sigmoid vein" ; rdfs:subClassOf _:genid161980 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_0039261 oboInOwl:hasDbXref "FMA:70471" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039261" ; a owl:Class ; rdfs:label "pancreatic artery" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001194 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001264 ] ) ] . obo:UBERON_0039355 oboInOwl:hasDbXref "FMA:20903" ; oboInOwl:hasExactSynonym "arteria urethralis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039355" ; a owl:Class ; rdfs:label "urethral artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0039377 obo:IAO_0000115 "A vein that drains the urethra." ; oboInOwl:hasDbXref "FMA:21270" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039377" ; a owl:Class ; rdfs:label "urethral vein" ; rdfs:subClassOf _:genid161996 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000057 ] ) ] . obo:UBERON_0039856 obo:IAO_0000115 "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." ; oboInOwl:hasDbXref "FMA:14342" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039856" ; a owl:Class ; rdfs:label "right ovarian vein" ; rdfs:subClassOf obo:UBERON_0001145, _:genid162004 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001145 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002118 ] ) ] . obo:UBERON_0039857 obo:IAO_0000115 "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." ; oboInOwl:hasDbXref "FMA:14347" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:0039857" ; a owl:Class ; rdfs:label "left ovarian vein" ; rdfs:subClassOf obo:UBERON_0001145 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001145 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0002119 ] ) ] . obo:UBERON_1000004 obo:IAO_0000115 "A collection of hairs that grows on the external ear." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "external ear hair" ; oboInOwl:id "UBERON:1000004" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "collection of hair on external ear" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0022279 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 ] ) ] . obo:UBERON_1000006 obo:IAO_0000115 "A collection of hairs that grows on the forehead." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000006" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "collection of hair on forehead" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010164 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008200 ] ) ] . obo:UBERON_1000009 obo:IAO_0000115 "A ridge or peak located along the middle part of the head, located approximately equidistant from the left and the right sides of the head." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000009" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "midline crest" ; rdfs:subClassOf obo:UBERON_0001444 . obo:UBERON_1000015 obo:IAO_0000115 "A zone of skin that is part of the snout." ; oboInOwl:hasDbXref "EMAPA:37746", "MA:0003079" ; oboInOwl:hasExactSynonym "snout skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000015" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "skin of snout" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006333 ] ) ] . obo:UBERON_1000020 obo:IAO_0000115 "A collection of hairs that grows on the snout." ; dcterms:contributor ; oboInOwl:creation_date "2012-02-05T05:21:29Z" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000020" ; oboInOwl:inSubset core:phenotype_rcn ; a owl:Class ; rdfs:label "collection of hair on snout" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006333 ] ) ] . obo:UBERON_1000021 obo:IAO_0000115 "A zone of skin that is part of the face." ; dcterms:contributor ; oboInOwl:creation_date "2012-02-05T05:23:01Z" ; oboInOwl:hasDbXref "EMAPA:36657", "FMA:24758", "NCIT:C33561", "SCTID:361703006", "UMLS:C0222084" ; oboInOwl:hasExactSynonym "face skin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "facial skin" ; oboInOwl:id "UBERON:1000021" ; oboInOwl:inSubset core:pheno_slim, core:phenotype_rcn ; a owl:Class ; rdfs:label "skin of face" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ] . obo:UBERON_1000023 obo:IAO_0000115 "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." ; oboInOwl:hasDbXref "EMAPA:35805", "FMA:15845", "MA:0002487", "NCIT:C33603", "SCTID:13515001", "UMLS:C0229691" ; oboInOwl:hasExactSynonym "Malpighian corpuscles", "pulp of spleen", "splenic pulp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000023" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "spleen pulp" ; rdfs:subClassOf obo:UBERON_0000064, _:genid162044 . obo:UBERON_1000024 obo:IAO_0000115 "A parenchyma that is part of a spleen." ; oboInOwl:hasDbXref "FMA:16029" ; oboInOwl:hasExactSynonym "splenic parenchyma" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1000024" ; a owl:Class ; rdfs:label "parenchyma of spleen" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002106 ] ) ] . obo:UBERON_1100000 obo:IAO_0000115 "An anatomical junction between two parts of the digestive tract." ; dcterms:contributor ; oboInOwl:creation_date "2021-02-05T11:19:31Z" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:1100000" ; a owl:Class ; rdfs:label "digestive tract junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004921 ] ) ] . obo:UBERON_2000238 obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0000238" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2000238" ; a owl:Class ; rdfs:label "olfactory tract linking bulb to ipsilateral ventral telencephalon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002265 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0000204 ] ) ] . obo:UBERON_2001053 oboInOwl:hasDbXref "EFO:0003612", "TAO:0001053", "ZFA:0001053" ; oboInOwl:hasExactSynonym "PICA", "primitive internal carotid artery" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001053" ; a owl:Class ; rdfs:label "future internal carotid artery" ; rdfs:subClassOf obo:UBERON_0001637, [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004363 ], _:genid162065 . obo:UBERON_2001073 obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0001073" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001073" ; a owl:Class ; rdfs:label "axial vasculature" ; rdfs:subClassOf obo:UBERON_0002049 . obo:UBERON_2001269 obo:IAO_0000115 "Fin or limb undergoing the process of regeneration." ; oboInOwl:hasDbXref "EFO:0003657", "TAO:0001269", "ZFA:0001269" ; oboInOwl:hasNarrowSynonym "regenerating fins" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001269" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "regenerating fin/limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004708 [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom obo:GO_0031099 ] ) ] . obo:UBERON_2001388 obo:IAO_0000115 "An epithelial-mesenchymal boundary that is part of a regenerating fin/limb." ; oboInOwl:hasDbXref "TAO:0001388", "ZFA:0001388" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001388" ; a owl:Class ; rdfs:label "epithelial mesenchymal boundary of regenerating fin/limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001269 ] ) ] . obo:UBERON_2001389 obo:IAO_0000115 "An epithelium that is part of a regenerating fin/limb." ; oboInOwl:hasBroadSynonym "epidermal cap", "wound epidermis", "wound epithelium" ; oboInOwl:hasDbXref "EFO:0003682", "TAO:0001389", "ZFA:0001389" ; oboInOwl:hasExactSynonym "epidermal cap of fin", "wound epidermis of fin", "wound epithelium of fin" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001389" ; oboInOwl:inSubset core:efo_slim ; a owl:Class ; rdfs:label "regeneration epithelium of fin/limb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_2001269 ] ) ] . obo:UBERON_2001457 obo:IAO_0000115 "Cartilage which is part of the axial skeleton." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0001457" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001457" ; a owl:Class ; rdfs:label "postcranial axial cartilage" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007844 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ] ) ] . obo:UBERON_2001626 obo:IAO_0000115 "Tooth that is attached to the premaxilla." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001626" ; a owl:Class ; rdfs:label "premaxillary tooth" ; rdfs:subClassOf obo:UBERON_0001091, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009680 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002244 ] ) ] . obo:UBERON_2001947 obo:IAO_0000115 "Joint that articulates the hyomandibular cartilage or bone and otic region cartilage or sphenotic bone, and often pterotic bone and prootic bone. Hyomandibular-otic region joint is paired." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0005544" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001947" ; a owl:Class ; rdfs:label "hyomandibular-otic region joint" ; rdfs:subClassOf obo:UBERON_0000982 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003110 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0011606 ] ) ] . obo:UBERON_2001950 obo:IAO_0000115 "Joint that articulates the left and right premaxillary bones. Inter-premaxillary joint is unpaired." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0005475" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2001950" ; a owl:Class ; rdfs:label "inter-premaxillary joint" ; rdfs:subClassOf obo:UBERON_0000982 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002244 ] ) ] . obo:UBERON_2002260 obo:IAO_0000115 "Joint that articulates the premaxilla and maxilla. Premaxillary-maxillary joint is paired." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2002260" ; a owl:Class ; rdfs:label "premaxillary-maxillary joint" ; rdfs:subClassOf obo:UBERON_0000982 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002244 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ] . obo:UBERON_2005260 obo:IAO_0000115 "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse." ; obo:IAO_0000116 "the ZFA class from which this was derived is not explicitly classified as a capillary - need to verify for taxon histology differences" ; obo:UBPROP_0000001 "Blood vessel endothelium that has pores that allow passage small molecules and proteins[ZFA]." ; oboInOwl:hasBroadSynonym "fenestrated blood vessel endothelium" ; oboInOwl:hasDbXref "FMA:63196", "NCIT:C32595", "TAO:0005260", "UMLS:C1179615", "Wikipedia:Capillary#Types", "ZFA:0005260" ; oboInOwl:hasExactSynonym "fenestrated capillary vessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2005260" ; a owl:Class ; rdfs:label "fenestrated capillary" ; rdfs:subClassOf obo:UBERON_0001982, obo:UBERON_0004638 . obo:UBERON_2005273 obo:IAO_0000115 "A thin layer of smooth muscle immediately beneath the base of the villi which permits the intestinal mucosa to dynamically move and fold." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0005273" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "intestinal lamina muscularis mucosae" ; oboInOwl:id "UBERON:2005273" ; a owl:Class ; rdfs:label "intestinal mucosal muscle" ; rdfs:subClassOf obo:UBERON_0001135, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] . obo:UBERON_2007013 obo:IAO_0000115 "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasDbXref "ZFA:0007013" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:2007013" ; a owl:Class ; rdfs:label "preplacodal ectoderm" ; rdfs:subClassOf obo:UBERON_0005497 . obo:UBERON_3000961 obo:IAO_0000115 "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3000961" ; a owl:Class ; rdfs:comment "Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305" ; rdfs:label "external integument structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0003102 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 ] ) ] . obo:UBERON_3000972 obo:IAO_0000115 "Dermal, epidermal, glandular and pigment structures of the external head integument." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3000972" ; a owl:Class ; rdfs:label "head external integument structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_3000961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ] . obo:UBERON_3000977 obo:IAO_0000115 "Dermal, epidermal, glandular and pigment structures of the body integument." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3000977" ; a owl:Class ; rdfs:label "body external integument structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_3000961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002100 ] ) ] . obo:UBERON_3000981 obo:IAO_0000115 "Dermal, epidermal, glandular and pigment structures of the limb integument." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3000981" ; a owl:Class ; rdfs:label "limb external integument structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_3000961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) ] . obo:UBERON_3000982 obo:IAO_0000115 "Dermal, epidermal, glandular and pigment structures of the tail integument." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3000982" ; a owl:Class ; rdfs:label "tail external integument structure" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_3000961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 ] ) ] . obo:UBERON_3010200 obo:IAO_0000115 "Blood vessels in respiratory skin." ; obo:IAO_0000116 "Modified from the original AAO source" ; obo:UBPROP_0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:3010200" ; a owl:Class ; rdfs:label "vasculature of respiratory integument" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 ] ) ] . obo:UBERON_4000013 obo:IAO_0000115 "Skeletal tissue that is mineralized." ; oboInOwl:hasBroadSynonym "mineralized tissue" ; oboInOwl:hasDbXref "VSAO:0000013", "XAO:0004039" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4000013" ; a owl:Class ; rdfs:label "mineralized skeletal tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004755 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002444 ] ) ] . obo:UBERON_4000020 obo:IAO_0000115 "Extracellular matrix that is mineralized." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (vertebrate_skeletal_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4000020" ; a owl:Class ; rdfs:label "mineralized extracellular matrix" ; rdfs:subClassOf obo:GO_0031012, obo:UBERON_0000479 . obo:UBERON_4000115 obo:IAO_0000115 "Bone tissue mineralized with hydroxyapatite." ; obo:UBPROP_0000004 "This class was sourced from an external ontology (vertebrate_skeletal_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4000115" ; a owl:Class ; rdfs:label "mineralized bone tissue" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_52255 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_4000020 ], _:genid159865 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002481 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002444 ] ) ] . obo:UBERON_4100000 obo:IAO_0000115 "Anatomical projection that is composed of bone or cartilage tissue." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4100000" ; a owl:Class ; rdfs:label "skeletal element projection" ; rdfs:subClassOf obo:UBERON_0004529 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004765 ] ) ] . obo:UBERON_4100117 obo:IAO_0000115 "Rib located anterior to the sacral region." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4100117" ; a owl:Class ; rdfs:label "presacral rib" ; rdfs:subClassOf obo:UBERON_0002228 . obo:UBERON_4200172 oboInOwl:hasDbXref "FMA:23356", "NCIT:C33164" ; oboInOwl:hasExactSynonym "collum anatomicum (Humerus)", "collum anatomicum humeri", "humeral neck" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "anatomic neck of humerus" ; oboInOwl:id "UBERON:4200172" ; a owl:Class ; rdfs:label "neck of humerus" ; rdfs:subClassOf obo:UBERON_0005913, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004411 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001560 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000976 ] ) ] . obo:UBERON_4200230 obo:IAO_0000115 "An anatomical surface that is part of a bone." ; oboInOwl:hasExactSynonym "bone surface" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4200230" ; a owl:Class ; rdfs:label "surface of bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006984 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001474 ] ) ] . obo:UBERON_4300226 obo:IAO_0000115 "Mesenchyme that is part of a forelimb bud." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4300226" ; a owl:Class ; rdfs:label "forelimb bud mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010328 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005417 ] ) ] . obo:UBERON_4300227 obo:IAO_0000115 "Mesenchyme that is part of a hindlimb bud." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:4300227" ; a owl:Class ; rdfs:label "hindlimb bud mesenchyme" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010328 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005418 ] ) ] . obo:UBERON_5001463 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit 1", "manual digit 1 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit 1 digitopodial subdivision", "manual digit 1 ray", "manual digit I plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5001463" ; a owl:Class ; rdfs:label "manual digit 1 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001463 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5101463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_5001466 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit", "pedal digit ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit digitopodial subdivision", "pedal digit ray" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5001466" ; a owl:Class ; rdfs:label "pedal digit plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001466 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5101466 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5002389 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit", "manual digit ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit digitopodial subdivision", "manual digit ray" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5002389" ; a owl:Class ; rdfs:label "manual digit plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002389 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5102389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid159924 ] . obo:UBERON_5002544 obo:IAO_0000115 "A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit", "digit ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit digitopodial subdivision", "digit ray" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5002544" ; a owl:Class ; rdfs:label "digit plus metapodial segment" ; rdfs:subClassOf _:genid159939, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000475 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5102544 ] ) ] . obo:UBERON_5003622 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit 2", "manual digit 2 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit 2 digitopodial subdivision", "manual digit 2 ray", "manual digit II plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003622" ; a owl:Class ; rdfs:label "manual digit 2 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003622 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_5003623 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit 3", "manual digit 3 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit 3 digitopodial subdivision", "manual digit 3 ray", "manual digit III plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003623" ; a owl:Class ; rdfs:label "manual digit 3 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003623 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_5003624 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit 4", "manual digit 4 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit 4 digitopodial subdivision", "manual digit 4 ray", "manual digit IV plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003624" ; a owl:Class ; rdfs:label "manual digit 4 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003624 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103624 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_5003625 obo:IAO_0000115 "A subdivision of the autopod consisting of manual digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "manual digit 5", "manual digit 5 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "manual digit 5 digitopodial subdivision", "manual digit 5 ray", "manual digit V plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003625" ; a owl:Class ; rdfs:label "manual digit 5 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5002389, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003625 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103625 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) ] . obo:UBERON_5003631 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit 1", "pedal digit 1 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit 1 digitopodial subdivision", "pedal digit 1 ray", "pedal digit I plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003631" ; a owl:Class ; rdfs:label "pedal digit 1 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003631 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006048 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5003632 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit 2", "pedal digit 2 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit 2 digitopodial subdivision", "pedal digit 2 ray", "pedal digit II plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003632" ; a owl:Class ; rdfs:label "pedal digit 2 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003632 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103632 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5003633 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit 3", "pedal digit 3 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit 3 digitopodial subdivision", "pedal digit 3 ray", "pedal digit III plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003633" ; a owl:Class ; rdfs:label "pedal digit 3 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003633 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006050 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5003634 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit 4", "pedal digit 4 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit 4 digitopodial subdivision", "pedal digit 4 ray", "pedal digit IV plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003634" ; a owl:Class ; rdfs:label "pedal digit 4 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003634 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006051 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5003635 obo:IAO_0000115 "A subdivision of the autopod consisting of pedal digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "pedal digit 5", "pedal digit 5 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "pedal digit 5 digitopodial subdivision", "pedal digit 5 ray", "pedal digit V plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5003635" ; a owl:Class ; rdfs:label "pedal digit 5 plus metapodial segment" ; rdfs:subClassOf obo:UBERON_5001466, [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003635 ], [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5103635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5006052 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) ] . obo:UBERON_5006048 obo:IAO_0000115 "A subdivision of the autopod consisting of digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit 1", "digit 1 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit 1 digitopodial subdivision", "digit 1 ray", "digit I plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5006048" ; a owl:Class ; rdfs:label "digit 1 plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5106048 ] ) ] . obo:UBERON_5006049 obo:IAO_0000115 "A subdivision of the autopod consisting of digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit 2", "digit 2 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit 2 digitopodial subdivision", "digit 2 ray", "digit II plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5006049" ; a owl:Class ; rdfs:label "digit 2 plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5106049 ] ) ] . obo:UBERON_5006050 obo:IAO_0000115 "A subdivision of the autopod consisting of digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit 3", "digit 3 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit 3 digitopodial subdivision", "digit 3 ray", "digit III plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5006050" ; a owl:Class ; rdfs:label "digit 3 plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5106050 ] ) ] . obo:UBERON_5006051 obo:IAO_0000115 "A subdivision of the autopod consisting of digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit 4", "digit 4 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit 4 digitopodial subdivision", "digit 4 ray", "digit IV plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5006051" ; a owl:Class ; rdfs:label "digit 4 plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5106051 ] ) ] . obo:UBERON_5006052 obo:IAO_0000115 "A subdivision of the autopod consisting of digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." ; oboInOwl:hasBroadSynonym "digit 5", "digit 5 ( phalanges plus metapodial) plus soft tissue" ; oboInOwl:hasExactSynonym "digit 5 digitopodial subdivision", "digit 5 ray", "digit V plus metapodial segment" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:5006052" ; a owl:Class ; rdfs:label "digit 5 plus metapodial segment" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_5106052 ] ) ] . obo:UBERON_5101463 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 1 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "manual digit I digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit 1", "manual digit 1 skeleton" ; oboInOwl:id "UBERON:5101463" ; a owl:Class ; rdfs:label "manual digit 1 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5001463 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5001463 ] ) ] . obo:UBERON_5101466 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit", "pedal digit skeleton" ; oboInOwl:id "UBERON:5101466" ; a owl:Class ; rdfs:label "pedal digit digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5001466 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 _:genid160136 ) ] . obo:UBERON_5102389 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit", "manual digit skeleton" ; oboInOwl:id "UBERON:5102389" ; a owl:Class ; rdfs:label "manual digit digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5002389 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5002389 ] ) ] . obo:UBERON_5102544 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit", "digit skeleton" ; oboInOwl:id "UBERON:5102544" ; a owl:Class ; rdfs:label "individual digit of digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5002544 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5002544 ] ) ] . obo:UBERON_5103622 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 2 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "manual digit II digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit 2", "manual digit 2 skeleton" ; oboInOwl:id "UBERON:5103622" ; a owl:Class ; rdfs:label "manual digit 2 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003622 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003622 ] ) ] . obo:UBERON_5103623 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 3 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "manual digit III digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit 3", "manual digit 3 skeleton" ; oboInOwl:id "UBERON:5103623" ; a owl:Class ; rdfs:label "manual digit 3 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003623 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003623 ] ) ] . obo:UBERON_5103624 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 4 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "manual digit IV digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit 4", "manual digit 4 skeleton" ; oboInOwl:id "UBERON:5103624" ; a owl:Class ; rdfs:label "manual digit 4 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003624 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003624 ] ) ] . obo:UBERON_5103625 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 5 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "manual digit V digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "manual digit 5", "manual digit 5 skeleton" ; oboInOwl:id "UBERON:5103625" ; a owl:Class ; rdfs:label "manual digit 5 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003625 ] ; owl:equivalentClass _:genid160191 . obo:UBERON_5103631 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 1 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "pedal digit I digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit 1", "pedal digit 1 skeleton" ; oboInOwl:id "UBERON:5103631" ; a owl:Class ; rdfs:label "pedal digit 1 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003631 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003631 ] ) ] . obo:UBERON_5103632 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 2 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "pedal digit II digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit 2", "pedal digit 2 skeleton" ; oboInOwl:id "UBERON:5103632" ; a owl:Class ; rdfs:label "pedal digit 2 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003632 ] ; owl:equivalentClass _:genid160211 . obo:UBERON_5103633 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 3 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "pedal digit III digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit 3", "pedal digit 3 skeleton" ; oboInOwl:id "UBERON:5103633" ; a owl:Class ; rdfs:label "pedal digit 3 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003633 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003633 ] ) ] . obo:UBERON_5103634 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 4 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "pedal digit IV digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit 4", "pedal digit 4 skeleton" ; oboInOwl:id "UBERON:5103634" ; a owl:Class ; rdfs:label "pedal digit 4 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003634 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003634 ] ) ] . obo:UBERON_5103635 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 5 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "pedal digit V digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "pedal digit 5", "pedal digit 5 skeleton" ; oboInOwl:id "UBERON:5103635" ; a owl:Class ; rdfs:label "pedal digit 5 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5003635 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003635 ] ) ] . obo:UBERON_5106048 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 1 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "digit I digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit 1", "digit 1 skeleton" ; oboInOwl:id "UBERON:5106048" ; a owl:Class ; rdfs:label "digit 1 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006048 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5006048 ] ) ] . obo:UBERON_5106049 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 2 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "digit II digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit 2", "digit 2 skeleton" ; oboInOwl:id "UBERON:5106049" ; a owl:Class ; rdfs:label "digit 2 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006049 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5006049 ] ) ] . obo:UBERON_5106050 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 3 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "digit III digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit 3", "digit 3 skeleton" ; oboInOwl:id "UBERON:5106050" ; a owl:Class ; rdfs:label "digit 3 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006050 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5006050 ] ) ] . obo:UBERON_5106051 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 4 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "digit IV digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit 4", "digit 4 skeleton" ; oboInOwl:id "UBERON:5106051" ; a owl:Class ; rdfs:label "digit 4 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006051 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5006051 ] ) ] . obo:UBERON_5106052 obo:IAO_0000115 "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 5 plus the associated metapodial element." ; obo:IAO_0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." ; oboInOwl:hasExactSynonym "digit V digitopodial skeleton" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "digit 5", "digit 5 skeleton" ; oboInOwl:id "UBERON:5106052" ; a owl:Class ; rdfs:label "digit 5 digitopodial skeleton" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 ], [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006052 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5006052 ] ) ] . obo:UBERON_7500046 obo:IAO_0000115 "The proximal-most point of the head of a femur." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500046" ; a owl:Class ; rdfs:label "proximal-most point of head of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006983 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0006767 ] ) ] . obo:UBERON_7500047 obo:IAO_0000115 "The proximal-most point of the head of a humerus." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500047" ; a owl:Class ; rdfs:label "proximal-most point of head of humerus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006983 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0006801 ] ) ] . obo:UBERON_7500049 obo:IAO_0000115 "The proximal-most point of the greater trochanter of a femur." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500049" ; a owl:Class ; rdfs:label "proximal-most point of greater trochanter of femur" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0006983 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001106 ; owl:someValuesFrom obo:UBERON_0002503 ] ) ] . obo:UBERON_7500062 obo:IAO_0000115 "The tibial tuberosity is on the anterior side of a tibia and is where a patella ligament attaches." ; dcterms:contributor ; oboInOwl:hasExactSynonym "fossa digitalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500062" ; a owl:Class ; rdfs:label "tibial tuberosity" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008772 ] ) ] . obo:UBERON_7500065 obo:IAO_0000115 "An articular prominence of a talus that engages with the tibia." ; dcterms:contributor ; oboInOwl:hasExactSynonym "condyle of astragalus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500065" ; a owl:Class ; rdfs:label "condyle of talus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002395 ] ) ] . obo:UBERON_7500073 obo:IAO_0000115 "Nasal bone on the left side of an organism when in anatomical position." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500073" ; a owl:Class ; rdfs:label "left nasal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001681 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_7500074 obo:IAO_0000115 "Nasal bone on the right side of an organism when in anatomical position." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500074" ; a owl:Class ; rdfs:label "right nasal bone" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001681 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_7500075 obo:IAO_0000115 "Zygomatic arch on the left side of an organism when in anatomical position." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500075" ; a owl:Class ; rdfs:label "left zygomatic arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002500 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_7500076 obo:IAO_0000115 "Zygomatic arch on the right side of an organism when in anatomical position." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500076" ; a owl:Class ; rdfs:label "right zygomatic arch" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002500 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_7500078 obo:IAO_0000115 "A condyle on the distal end and lateral side of a radius." ; dcterms:contributor ; oboInOwl:hasExactSynonym "radial condyle", "radial styloid process" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500078" ; a owl:Class ; rdfs:label "styloid process of radius" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004407 ] ) ] . obo:UBERON_7500094 obo:IAO_0000115 "A raised projection on the calcaneus." ; dcterms:contributor ; oboInOwl:hasExactSynonym "calcaneal tubercle", "calcaneal tuberosity", "tuberosity of calcaneus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500094" ; a owl:Class ; rdfs:label "tubercle of calcaneus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0005813 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001450 ] ) ] . obo:UBERON_7500102 obo:IAO_0000115 "Part of the orbital plate formed by the jugal (part of the zygomatic), lacrimal (which is sometimes fused), sometimes nasal (typically in species with elongated rostra), and maxilla bones anterior to the orbit." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500102" ; a owl:Class ; rdfs:label "preorbital bone region" ; rdfs:subClassOf obo:UBERON_0001062, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001697 ] . obo:UBERON_7500103 obo:IAO_0000115 "A hollow (fossa) in the preorbital region, typically lying on the maxillary bone, although sometimes can touch nasal bones (e.g., modern Equus)." ; dcterms:contributor , ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500103" ; a owl:Class ; rdfs:label "preorbital fossa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0004704 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_7500102 ] ) ] . obo:UBERON_7500107 obo:IAO_0000115 "A suture joining a sphenoid bone with the alae of a vomer to form a schindylesis type of joint." ; dcterms:contributor , ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:7500107" ; a owl:Class ; rdfs:label "sphenovomerine suture" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009199 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002396 ] ) ] . obo:UBERON_8000006 obo:IAO_0000115 "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8000006" ; a owl:Class ; rdfs:label "left side of back" ; rdfs:subClassOf obo:UBERON_0001137 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001137 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_8000007 obo:IAO_0000115 "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8000007" ; a owl:Class ; rdfs:label "right side of back" ; rdfs:subClassOf obo:UBERON_0001137 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001137 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] . obo:UBERON_8300000 obo:IAO_0000115 "A zone of skin that is part of a scalp." ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:24757" ; oboInOwl:hasExactSynonym "adult scalp zone of skin", "scalp skin", "scalp zone of skin", "zone of skin of adult scalp", "zone of skin of scalp" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8300000" ; a owl:Class ; rdfs:label "skin of scalp" ; rdfs:subClassOf obo:UBERON_0000014 ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ) ] . obo:UBERON_8300001 obo:IAO_0000115 "A forelimb that is on the right side of a pectoral complex." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:7185" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8300001" ; a owl:Class ; rdfs:label "right forelimb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002102 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_8300002 obo:IAO_0000115 "A forelimb that is on the left side of a pectoral complex." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:7186" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8300002" ; a owl:Class ; rdfs:label "left forelimb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002102 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ] . obo:UBERON_8300003 obo:IAO_0000115 "A hindlimb that is on the right side of a pelvic complex." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:7187" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8300003" ; a owl:Class ; rdfs:label "right hindlimb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002103 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_8300004 obo:IAO_0000115 "A hindlimb that is on the left side of a pelvic complex." ; obo:UBPROP_0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern"^^xsd:anyURI ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:7188" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8300004" ; a owl:Class ; rdfs:label "left hindlimb" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002103 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ] . obo:UBERON_8400021 obo:IAO_0000115 "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." ; dcterms:contributor ; oboInOwl:hasExactSynonym "serosa of liver", "tunica serosa hepatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8400021" ; a owl:Class ; rdfs:label "liver serosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_8400023 obo:IAO_0000115 "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." ; dcterms:contributor ; oboInOwl:hasExactSynonym "hepatic subserosa", "subserosal tissue of liver", "subserous layer of liver", "tela subserosa (hepar)", "tela subserosa hepatis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8400023" ; a owl:Class ; rdfs:label "liver subserosa" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012375 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ] . obo:UBERON_8400024 obo:IAO_0000115 "Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses." ; dcterms:contributor ; oboInOwl:hasExactSynonym "liver subcapsular region", "liver subcapsular tissue", "subcapsular tissue of liver" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8400024" ; a owl:Class ; rdfs:label "subcapsular region of liver" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0016479 ] ) ] . obo:UBERON_8410000 obo:IAO_0000115 "The anatomical junction between the duodenum and the jejunum." ; oboInOwl:hasDbXref "FMA:15957", "TA2:2952", "WikipediaVersioned:Duodenojejunal_flexure&oldid=937307798", "https://orcid.org/0000-0003-4183-8865" ; oboInOwl:hasExactSynonym "duodeno-jejunal flexure", "duodenojejunal flexure", "duodenojejunal junction", "flexura duodenojejunalis" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410000" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "duodeno-jejunal junction" ; rdfs:subClassOf obo:UBERON_0007651, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002114 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ] . obo:UBERON_8410001 obo:IAO_0000115 "Venule of villus of small intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "venule of small intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410001" ; oboInOwl:inSubset core:location_grouping ; a owl:Class ; rdfs:label "small intestine venule" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:UBERON_8410002 obo:IAO_0000115 "A lymphatic vessel that supplies the small intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "lymphatic vessel of small intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410002" ; oboInOwl:inSubset core:location_grouping ; a owl:Class ; rdfs:label "small intestine lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_8410004 obo:IAO_0000115 "Arteriole of villus of small intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "arteriole of small intestine", "arteriole of villus of small intestine", "small intestine villus arteriole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410004" ; oboInOwl:inSubset core:location_grouping ; a owl:Class ; rdfs:label "small intestine arteriole" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001213 ] ) ] . obo:UBERON_8410008 obo:IAO_0000115 "A venule that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "anorectum venule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410008" ; a owl:Class ; rdfs:label "venule of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:UBERON_8410009 obo:IAO_0000115 "An arteriole that is located in the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "anorectum arteriole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410009" ; a owl:Class ; rdfs:label "arteriole of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:UBERON_8410015 obo:IAO_0000115 "An arteriole located in the colon." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410015" ; a owl:Class ; rdfs:label "arteriole of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_8410016 obo:IAO_0000115 "The anatomical junction between the descending colon and the sigmoid colon." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "sigmoid junction" ; oboInOwl:hasExactSynonym "descending-sigmoid colon junction", "descending-sigmoid junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410016" ; a owl:Class ; rdfs:label "descending sigmoid junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000168 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001158 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001159 ] ) ] . obo:UBERON_8410017 obo:IAO_0000115 "A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery." ; dcterms:contributor ; oboInOwl:hasDbXref "FMA:15394" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410017" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "left colic vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002017 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001158 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001215 ] ) ] . obo:UBERON_8410019 obo:IAO_0000115 "The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "jejunoileal junction" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410019" ; a owl:Class ; rdfs:label "jejuno-ileal junction" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002115 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002116 ] ) ] . obo:UBERON_8410024 obo:IAO_0000115 "An anatomical junction between two parts of the intestine." ; dcterms:contributor ; oboInOwl:hasExactSynonym "junction of intestine" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410024" ; a owl:Class ; rdfs:label "intestinal junction" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0007651 _:genid160493 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004921 ] ) ] . obo:UBERON_8410032 obo:IAO_0000115 "The trabecular sinus is the lymph-filled space outside the trabeculae between lobules of the lymph node. This is a continuation of the subcapsular sinus which receives the afferent vessels and is present beneath the capsule. This space is traversed by both reticular fibers and cells in the lymph." ; dcterms:contributor ; oboInOwl:hasExactSynonym "lymph node trabecular sinus" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410032" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "trabecular sinus of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002195 ] ) ] . obo:UBERON_8410033 obo:IAO_0000115 "A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein." ; dcterms:contributor ; oboInOwl:hasExactSynonym "hilar vein of lymph node", "vein of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410033" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_8410034 obo:IAO_0000115 "An artery that enters the lymph node at the hilum and branches into smaller arterioles." ; oboInOwl:hasExactSynonym "artery of lymph node", "hilar artery of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410034" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "lymph node artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_8410035 obo:IAO_0000115 "An arteriole that arises from the hilar artery of a lymph node and radiates centrifugally, branching in the medulla." ; dcterms:contributor ; oboInOwl:hasExactSynonym "arteriole of medulla of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410035" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary arteriole of lymph node" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_8410034 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ] ) ] . obo:UBERON_8410036 obo:IAO_0000115 "Medullary venules are a continuation of high endothelial venules which condense repeatedly in the interfollicular cortex and peripheral deep cortical unit and then transition to medullary venules at the corticomedullary junction. The medullary venules condense and return centripetally to the hilar vein." ; dcterms:contributor ; oboInOwl:hasExactSynonym "venule of medulla of lymph node" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410036" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "medullary venule of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002007 ] ) ] . obo:UBERON_8410041 obo:IAO_0000115 "A venule that is part of a lymph node." ; dcterms:contributor ; oboInOwl:hasExactSynonym "lymph node venule" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410041" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "venule of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_8410042 obo:IAO_0000115 "An arteriole that is part of a lymph node." ; dcterms:contributor ; oboInOwl:hasExactSynonym "lymph node arteriole" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410042" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "arteriole of lymph node" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001980 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) ] . obo:UBERON_8410043 obo:IAO_0000115 "A submucosal gland located in a bronchus." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "airway submucosal gland" ; oboInOwl:hasExactSynonym "bronchial submucosal gland", "submucosal bronchial gland", "submucosal bronchus gland" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410043" ; oboInOwl:inSubset core:human_reference_atlas ; a owl:Class ; rdfs:label "bronchus submucosal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011148 _:genid160538 ) ] . obo:UBERON_8410048 obo:IAO_0000115 "A venule located in the colon." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410048" ; a owl:Class ; rdfs:label "venule of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001979 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_8410050 obo:IAO_0000115 "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." ; obo:IAO_0000116 "The anatomy, pathology and medical community considers the anus to be part of the large intestine, and supports the use of 'anorectum' to include rectum, anal canal and anus. Although a few resources seem to only include the distal part of the rectum in 'anorectum', this UBERON grouping term is meant to refer more broadly to the whole of rectum." ; obo:UBPROP_0000007 "anorectal" ; dcterms:contributor ; oboInOwl:hasNarrowSynonym "anorectal canal" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410050" ; a owl:Class ; rdfs:label "anorectum" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 ] ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid160547 ] . obo:UBERON_8410051 obo:IAO_0000115 "A lymphatic vessel located in the colon." ; dcterms:contributor ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410051" ; a owl:Class ; rdfs:label "lymphatic vessel of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_8410056 obo:IAO_0000115 "A capillary that is part of the anorectum." ; dcterms:contributor ; oboInOwl:hasExactSynonym "blood vessel capillary of anorectum" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410056" ; a owl:Class ; rdfs:label "capillary of anorectum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8410050 ] ) ] . obo:UBERON_8410057 obo:IAO_0000115 "A capillary that is part of the colon." ; dcterms:contributor ; oboInOwl:hasExactSynonym "blood vessel capillary of colon" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410057" ; a owl:Class ; rdfs:label "capillary of colon" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) ] . obo:UBERON_8410068 obo:IAO_0000115 "A capillary that is part of a small intestine." ; dcterms:contributor ; dcterms:date "2021-12-21T15:14:31Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "blood vessel capillary of small intestine", "small intestine capillary" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410068" ; oboInOwl:inSubset core:location_grouping ; a owl:Class ; rdfs:label "capillary of small intestine" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002108 ] ) ] . obo:UBERON_8410077 obo:IAO_0000115 "A submucosal gland found in a respiratory tract." ; dcterms:contributor ; dcterms:date "2022-03-24T14:21:59Z"^^xsd:dateTime ; oboInOwl:hasDbXref "EFO:0010666" ; oboInOwl:hasExactSynonym "respiratory tract submucosal gland", "submucosal gland of respiratory tract" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410077" ; a owl:Class ; rdfs:label "airway submucosal gland" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0011148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ] . obo:UBERON_8410079 obo:IAO_0000115 "Red bone marrow located in an iliac crest." ; oboInOwl:created_by "http://orcid.org/0000-0002-2825-0621" ; oboInOwl:hasExactSynonym "iliac crest red bone marrow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410079" ; a owl:Class ; rdfs:comment "The iliac crest has a large amount of red bone marrow, and thus it is the site of bone marrow harvests (from both sides) to collect the stem cells used in bone marrow transplantation." ; rdfs:label "red bone marrow of iliac crest" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014437 ] ) ] . obo:UBERON_8410080 obo:IAO_0000115 "Red bone marrow located in the sternum." ; oboInOwl:created_by "http://orcid.org/0000-0002-2825-0621" ; oboInOwl:hasExactSynonym "sternum red bone marrow" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410080" ; a owl:Class ; rdfs:label "red bone marrow of sternum" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000361 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 ] ) ] . obo:UBERON_8410081 obo:IAO_0000115 "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." ; obo:UBPROP_0000007 "microvascular" ; oboInOwl:created_by "http://orcid.org/0000-0002-2825-0621" ; oboInOwl:hasBroadSynonym "microvasculature", "microvessel" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8410081" ; a owl:Class ; rdfs:label "blood microvessel" ; rdfs:seeAlso "https://github.com/obophenotype/uberon/issues/2186" ; rdfs:subClassOf obo:UBERON_0001981, obo:UBERON_0010523 . obo:UBERON_8420000 obo:IAO_0000115 "Hair that grows on the scalp." ; dcterms:contributor ; oboInOwl:hasBroadSynonym "hair" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8420000" ; a owl:Class ; rdfs:label "hair of scalp" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403 ] ) ] . obo:UBERON_8440004 obo:IAO_0000115 "One or a subset of adjacent layers of the neocortex." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8440004" ; a owl:Class ; rdfs:label "laminar subdivision of the cortex" ; rdfs:subClassOf obo:UBERON_0011215, [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001950 ] . obo:UBERON_8440015 obo:IAO_0000115 "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8440015" ; a owl:Class ; rdfs:label "noradrenergic cell groups" ; rdfs:subClassOf obo:UBERON_0002616, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000459 ] . obo:UBERON_8450002 obo:IAO_0000115 "An anatomical system that eliminates waste products that arise as a result of metabolic activity." ; oboInOwl:created_by "http://orcid.org/0000-0002-6095-8718" ; oboInOwl:creation_date "2022-05-25T18:21:29Z" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8450002" ; a owl:Class ; rdfs:label "excretory system" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000467 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046903 ] ) ] . obo:UBERON_8470000 obo:IAO_0000115 "Blood located in the placenta." ; dcterms:contributor ; dcterms:date "2022-04-04T11:06:09Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8470000" ; a owl:Class ; rdfs:label "placental blood" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000178 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:UBERON_8470001 obo:IAO_0000115 "A lymph node with a lymph center located within the caudal abdomen and pelvis, on the ventral side of the lumbar region. Includes the medial iliac, internal iliac (previously termed hypogastric) and sacral lymph nodes." ; dcterms:contributor ; dcterms:date "2022-05-26T11:59:51Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8470001" ; a owl:Class ; rdfs:label "sublumbar lymph node" ; rdfs:subClassOf obo:UBERON_0000029 . obo:UBERON_8480000 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an iliac vein." ; dcterms:contributor ; dcterms:date "2022-06-17T14:34:50Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480000" ; a owl:Class ; rdfs:label "iliac vein smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005610 ] ) ] . obo:UBERON_8480001 obo:IAO_0000115 "A capillary that is part of the brain." ; dcterms:contributor ; dcterms:date "2022-06-24T09:28:31Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480001" ; a owl:Class ; rdfs:label "capillary of brain" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001982 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) ] . obo:UBERON_8480002 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of the thoracic aorta." ; dcterms:contributor ; dcterms:date "2022-06-24T09:30:54Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480002" ; a owl:Class ; rdfs:label "thoracic aorta smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001515 ] ) ] . obo:UBERON_8480003 obo:IAO_0000115 "A portion of smooth muscle tissue that is part of an iliac artery." ; dcterms:contributor ; dcterms:date "2022-06-24T09:32:07Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480003" ; a owl:Class ; rdfs:label "iliac artery smooth muscle tissue" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005609 ] ) ] . obo:UBERON_8480004 obo:IAO_0000115 "An endothelium that is part of an iliac vein." ; dcterms:contributor ; dcterms:date "2022-06-24T09:33:18Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480004" ; a owl:Class ; rdfs:label "iliac vein endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005610 ] ) ] . obo:UBERON_8480005 obo:IAO_0000115 "An endothelium that is part of the placental artery." ; dcterms:contributor ; dcterms:date "2022-06-24T09:34:25Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480005" ; a owl:Class ; rdfs:label "placental artery endothelium" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_8480007 ] ) ] . obo:UBERON_8480006 obo:IAO_0000115 "Lymphatic vessel that is part of the mesentery." ; dcterms:contributor ; dcterms:date "2022-06-24T09:35:29Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480006" ; a owl:Class ; rdfs:label "mesenteric lymphatic vessel" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 ] ) ] . obo:UBERON_8480007 obo:IAO_0000115 "An artery that is part of the placenta." ; dcterms:contributor ; dcterms:date "2022-06-24T11:25:24Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480007" ; a owl:Class ; rdfs:label "placental artery" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:UBERON_8480008 obo:IAO_0000115 "A vein that is part of the placenta." ; dcterms:contributor ; dcterms:date "2022-06-27T09:30:52Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480008" ; a owl:Class ; rdfs:label "placental vein" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 ] ) ] . obo:UBERON_8480014 obo:IAO_0000115 "A zone of skin that is part of the buttock." ; dcterms:contributor ; dcterms:date "2022-08-29T14:05:55Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480014" ; a owl:Class ; rdfs:label "skin of buttock" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0013691 ] ) ] . obo:UBERON_8480024 obo:IAO_0000115 "A zone of skin that is part of the sacral region." ; dcterms:contributor ; dcterms:date "2022-08-29T14:14:27Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480024" ; a owl:Class ; rdfs:label "skin of sacral region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005473 ] ) ] . obo:UBERON_8480025 obo:IAO_0000115 "A zone of skin that is above the clavicle zone in the pectoral girdle region." ; dcterms:contributor ; dcterms:date "2022-08-29T14:17:12Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480025" ; a owl:Class ; rdfs:label "skin of clavicle region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421 ] ) ] . obo:UBERON_8480026 obo:IAO_0000115 "A zone of skin that is above the iliac crest in the pelvic girdle bone/zone." ; dcterms:contributor ; dcterms:date "2022-08-29T14:19:16Z"^^xsd:dateTime ; oboInOwl:hasBroadSynonym "skin of posterior iliac crest region" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480026" ; a owl:Class ; rdfs:label "skin of iliac crest region" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007830 ] ) ] . obo:UBERON_8480029 obo:IAO_0000115 "A zone of skin that is part of the external genitalia." ; dcterms:contributor ; dcterms:date "2022-08-30T06:55:06Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480029" ; a owl:Class ; rdfs:label "skin of external genitalia" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004176 ] ) ] . obo:UBERON_8480030 obo:IAO_0000115 "A zone of skin that is part of the breast." ; dcterms:contributor ; dcterms:date "2022-08-29T14:03:54Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480030" ; a owl:Class ; rdfs:label "skin of breast" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 ] ) ] . obo:UBERON_8480037 obo:IAO_0000115 "Subserosa that is part of the uterine tube. It contains loose connective tissue, blood vessels and lymphatic tissue." ; dcterms:contributor ; dcterms:date "2022-10-21T08:55:11Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "subserosa of fallopian tube", "subserosa of oviduct" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8480037" ; a owl:Class ; rdfs:label "subserosa of uterine tube" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0012375 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 ] ) ] . obo:UBERON_8490001 obo:IAO_0000115 "A upper second secondary molar tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 2", "FDI tooth 17", "right upper second secondary molar tooth" ; a owl:Class ; rdfs:label "right upper second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018576 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490002 obo:IAO_0000115 "A upper first secondary molar tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 3", "FDI tooth 16", "right upper first secondary molar tooth" ; a owl:Class ; rdfs:label "right upper first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018575 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490005 obo:IAO_0000115 "A upper secondary canine tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 6", "FDI tooth 13", "right upper secondary canine tooth" ; a owl:Class ; rdfs:label "right upper secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018561 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490006 obo:IAO_0000115 "A upper lateral secondary incisor tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 7", "FDI tooth 12", "right upper lateral secondary incisor tooth" ; a owl:Class ; rdfs:label "right upper lateral secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016455 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490007 obo:IAO_0000115 "A upper central secondary incisor tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 8", "FDI tooth 11", "right upper central secondary incisor tooth" ; a owl:Class ; rdfs:label "right upper central secondary incisor tooth" ; owl:equivalentClass _:genid160715 . obo:UBERON_8490009 obo:IAO_0000115 "A lower second secondary molar tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 31", "FDI tooth 47", "right lower second secondary molar tooth" ; a owl:Class ; rdfs:label "right lower second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018579 _:genid160722 ) ] . obo:UBERON_8490010 obo:IAO_0000115 "A lower first secondary molar tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 30", "FDI tooth 46", "right lower first secondary molar tooth" ; a owl:Class ; rdfs:label "right lower first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018578 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490013 obo:IAO_0000115 "A lower secondary canine tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 27", "FDI tooth 43", "right lower secondary canine tooth" ; a owl:Class ; rdfs:label "right lower secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018562 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490014 obo:IAO_0000115 "A lower lateral secondary incisor tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 26", "FDI tooth 42", "right lower lateral secondary incisor tooth" ; a owl:Class ; rdfs:label "right lower lateral secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018570 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490015 obo:IAO_0000115 "A lower central secondary incisor tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 25", "FDI tooth 41", "right lower central secondary incisor tooth" ; a owl:Class ; rdfs:label "right lower central secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018568 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490016 obo:IAO_0000115 "A upper second primary molar tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth A", "FDI tooth 55", "right upper second primary molar tooth" ; a owl:Class ; rdfs:label "right upper second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018599 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490017 obo:IAO_0000115 "A upper first primary molar tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth B", "FDI tooth 54", "right upper first primary molar tooth" ; a owl:Class ; rdfs:label "right upper first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018588 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490018 obo:IAO_0000115 "A upper primary canine tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth C", "FDI tooth 53", "right upper primary canine tooth" ; a owl:Class ; rdfs:label "right upper primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018597 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490019 obo:IAO_0000115 "A upper lateral primary incisor tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth D", "FDI tooth 52", "right upper lateral primary incisor tooth" ; a owl:Class ; rdfs:label "right upper lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018594 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490020 obo:IAO_0000115 "A upper central primary incisor tooth that is in the right side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth E", "FDI tooth 51", "right upper central primary incisor tooth" ; a owl:Class ; rdfs:label "right upper central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018593 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490021 obo:IAO_0000115 "A lower second primary molar tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth T", "FDI tooth 85", "right lower second primary molar tooth" ; a owl:Class ; rdfs:label "right lower second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018600 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490022 obo:IAO_0000115 "A lower first primary molar tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth S", "FDI tooth 84", "right lower first primary molar tooth" ; a owl:Class ; rdfs:label "right lower first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018589 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490023 obo:IAO_0000115 "A lower primary canine tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth R", "FDI tooth 83", "right lower primary canine tooth" ; a owl:Class ; rdfs:label "right lower primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018598 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490024 obo:IAO_0000115 "A lower lateral primary incisor tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth Q", "FDI tooth 82", "right lower lateral primary incisor tooth" ; a owl:Class ; rdfs:label "right lower lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018596 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490025 obo:IAO_0000115 "A lower central primary incisor tooth that is in the right side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-13T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth P", "FDI tooth 81", "right lower central primary incisor tooth" ; a owl:Class ; rdfs:label "right lower central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018595 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490027 obo:IAO_0000115 "A upper second secondary molar tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 15", "FDI tooth 27", "left upper second secondary molar tooth" ; a owl:Class ; rdfs:label "left upper second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018576 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490028 obo:IAO_0000115 "A upper first secondary molar tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 14", "FDI tooth 26", "left upper first secondary molar tooth" ; a owl:Class ; rdfs:label "left upper first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018575 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490031 obo:IAO_0000115 "A upper secondary canine tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 11", "FDI tooth 23", "left upper secondary canine tooth" ; a owl:Class ; rdfs:label "left upper secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018561 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490032 obo:IAO_0000115 "A upper lateral secondary incisor tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 10", "FDI tooth 22", "left upper lateral secondary incisor tooth" ; a owl:Class ; rdfs:label "left upper lateral secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016455 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490033 obo:IAO_0000115 "A upper central secondary incisor tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 9", "FDI tooth 21", "left upper central secondary incisor tooth" ; a owl:Class ; rdfs:label "left upper central secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0016454 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490035 obo:IAO_0000115 "A lower second secondary molar tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 18", "FDI tooth 37", "left lower second secondary molar tooth" ; a owl:Class ; rdfs:label "left lower second secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018579 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490036 obo:IAO_0000115 "A lower first secondary molar tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 19", "FDI tooth 36", "left lower first secondary molar tooth" ; a owl:Class ; rdfs:label "left lower first secondary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018578 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490039 obo:IAO_0000115 "A lower secondary canine tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 22", "FDI tooth 33", "left lower secondary canine tooth" ; a owl:Class ; rdfs:label "left lower secondary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018562 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490040 obo:IAO_0000115 "A lower lateral secondary incisor tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 23", "FDI tooth 32", "left lower lateral secondary incisor tooth" ; a owl:Class ; rdfs:label "left lower lateral secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018570 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490041 obo:IAO_0000115 "A lower central secondary incisor tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth 24", "FDI tooth 31", "left lower central secondary incisor tooth" ; a owl:Class ; rdfs:label "left lower central secondary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018568 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490042 obo:IAO_0000115 "A upper second primary molar tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth J", "FDI tooth 65", "left upper second primary molar tooth" ; a owl:Class ; rdfs:label "left upper second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018599 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490043 obo:IAO_0000115 "A upper first primary molar tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth I", "FDI tooth 64", "left upper first primary molar tooth" ; a owl:Class ; rdfs:label "left upper first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018588 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490044 obo:IAO_0000115 "A upper primary canine tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth H", "FDI tooth 63", "left upper primary canine tooth" ; a owl:Class ; rdfs:label "left upper primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018597 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490045 obo:IAO_0000115 "A upper lateral primary incisor tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth G", "FDI tooth 62", "left upper lateral primary incisor tooth" ; a owl:Class ; rdfs:label "left upper lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid160861 ] . obo:UBERON_8490046 obo:IAO_0000115 "A upper central primary incisor tooth that is in the left side of the upper jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth F", "FDI tooth 61", "left upper central primary incisor tooth" ; a owl:Class ; rdfs:label "left upper central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018593 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ] . obo:UBERON_8490047 obo:IAO_0000115 "A lower second primary molar tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth K", "FDI tooth 75", "left lower second primary molar tooth" ; a owl:Class ; rdfs:label "left lower second primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018600 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490048 obo:IAO_0000115 "A lower first primary molar tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth L", "FDI tooth 74", "left lower first primary molar tooth" ; a owl:Class ; rdfs:label "left lower first primary molar tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018589 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490049 obo:IAO_0000115 "A lower primary canine tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth M", "FDI tooth 73", "left lower primary canine tooth" ; a owl:Class ; rdfs:label "left lower primary canine tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018598 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490050 obo:IAO_0000115 "A lower lateral primary incisor tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth N", "FDI tooth 72", "left lower lateral primary incisor tooth" ; a owl:Class ; rdfs:label "left lower lateral primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018596 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8490051 obo:IAO_0000115 "A lower central primary incisor tooth that is in the left side of the lower jaw region." ; dcterms:contributor ; oboInOwl:creation_date "2022-11-18T00:00:00Z" ; oboInOwl:hasExactSynonym "ADA tooth O", "FDI tooth 71", "left lower central primary incisor tooth" ; a owl:Class ; rdfs:label "left lower central primary incisor tooth" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0018595 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ] . obo:UBERON_8600004 obo:IAO_0000115 "A muscle tissue that is associated with soft internal organs (viscera)." ; dcterms:contributor ; dcterms:date "2023-02-16T10:17:46Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "visceral muscle" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8600004" ; a owl:Class ; rdfs:comment "It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated." ; rdfs:label "visceral muscle tissue" ; rdfs:subClassOf obo:UBERON_0002385, [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0008007 ] . obo:UBERON_8600006 obo:IAO_0000115 "A striated muscle tissue that is associated with soft internal organs (viscera)." ; dcterms:contributor ; dcterms:date "2023-02-16T10:34:43Z"^^xsd:dateTime ; oboInOwl:hasExactSynonym "striated visceral muscle tissue" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8600006" ; a owl:Class ; rdfs:label "visceral striated muscle tissue" ; rdfs:subClassOf obo:UBERON_0002036, obo:UBERON_8600004 . obo:UBERON_8600012 obo:IAO_0000115 "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium." ; dcterms:contributor ; dcterms:date "2023-05-02T08:57:27Z"^^xsd:dateTime ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "UBERON:8600012" ; a owl:Class ; rdfs:label "submucosal gland acinus" ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:UBERON_0009842 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011148 ] ) ] . obo:UBPROP_0000001 a owl:AnnotationProperty . obo:UBPROP_0000002 a owl:AnnotationProperty . obo:UBPROP_0000003 a owl:AnnotationProperty . obo:UBPROP_0000004 a owl:AnnotationProperty . obo:UBPROP_0000005 a owl:AnnotationProperty . obo:UBPROP_0000006 a owl:AnnotationProperty . obo:UBPROP_0000007 a owl:AnnotationProperty . obo:UBPROP_0000008 a owl:AnnotationProperty . obo:UBPROP_0000009 a owl:AnnotationProperty . obo:UBPROP_0000010 a owl:AnnotationProperty . obo:UBPROP_0000011 a owl:AnnotationProperty . obo:UBPROP_0000012 a owl:AnnotationProperty . obo:UBPROP_0000013 a owl:AnnotationProperty . obo:UBPROP_0000014 a owl:AnnotationProperty . obo:UBPROP_0000015 a owl:AnnotationProperty . obo:UBPROP_0000103 a owl:AnnotationProperty . obo:UBPROP_0000104 a owl:AnnotationProperty . obo:UBPROP_0000105 a owl:AnnotationProperty . obo:UBPROP_0000106 a owl:AnnotationProperty . obo:UBPROP_0000107 a owl:AnnotationProperty . obo:UBPROP_0000111 a owl:AnnotationProperty . obo:UBPROP_0000202 a owl:AnnotationProperty . caloha-reqs-vetted:PLURAL a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . chebi5:_STAR a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . chebi3:_STAR a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . chebi4:_STAR a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . chebi1:BRAND_NAME a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . chebi1:INN a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . chebi1:IUPAC_NAME a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . chebi1:has_functional_parent a owl:ObjectProperty . chebi1:has_parent_hydride a owl:ObjectProperty . chebi1:is_conjugate_acid_of a owl:ObjectProperty . chebi1:is_conjugate_base_of a owl:ObjectProperty . chebi1:is_enantiomer_of a owl:ObjectProperty . chebi1:is_substituent_group_from a owl:ObjectProperty . chebi1:is_tautomer_of a owl:ObjectProperty . chebi:charge a owl:AnnotationProperty . chebi:formula a owl:AnnotationProperty . chebi:inchi a owl:AnnotationProperty . chebi:inchikey a owl:AnnotationProperty . chebi:mass a owl:AnnotationProperty . chebi:monoisotopicmass a owl:AnnotationProperty . chebi:smiles a owl:AnnotationProperty . cl:BDS_subset a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:PLURAL a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . cl:abbreviation a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . cl:added_for_HCA a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:blood_and_immune_upper_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:eye_upper_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . cl:general_cell_types_upper_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:gocheck_do_not_annotate a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:gocheck_do_not_manually_annotate a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_agr a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_candida a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_chembl a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_drosophila a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_flybase_ribbon a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_generic a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_metagenomics a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_mouse a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_pir a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_plant a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_pombe a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_synapse a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:goslim_yeast a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:prokaryote_subset a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . go:syngo_official_label a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . go:systematic_synonym a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:abbreviation dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "abbreviation" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:display_label dc:date "2018-07-05T13:18:08Z"^^xsd:dateTime ; dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "display label" . hp:hposlim_core a owl:AnnotationProperty ; rdfs:comment "Core clinical terminology" ; rdfs:subPropertyOf oboInOwl:SubsetProperty . hp:layperson dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "layperson term" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:obsolete_synonym dc:date "2018-05-05T19:01:17Z"^^xsd:dateTime ; dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "discarded/obsoleted synonym" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:plural_form dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "plural form" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:secondary_consequence a owl:AnnotationProperty ; rdfs:comment "Consequence of a disorder in another organ system." ; rdfs:subPropertyOf oboInOwl:SubsetProperty . hp:uk_spelling dcterms:creator ; a owl:AnnotationProperty ; rdfs:label "UK spelling" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . obo:IAO_0000700 obo:HP_0000001 ; dc:creator "Human Phenotype Ontology Consortium", "Monarch Initiative", "Peter Robinson", "Sebastian Köhler" ; dc:description "The Human Phenotype Ontology (HPO) provides a standardized vocabulary of phenotypic abnormalities and clinical features encountered in human disease." ; dc:rights "Peter Robinson, Sebastian Koehler, The Human Phenotype Ontology Consortium, and The Monarch Initiative" ; dc:subject "Phenotypic abnormalities encountered in human disease" ; dc:title "Human Phenotype Ontology" ; dcterms:license ; oboInOwl:default-namespace "human_phenotype" ; oboInOwl:logical-definition-view-relation "has_part" ; a owl:Ontology ; rdfs:comment "Please see license of HPO at http://www.human-phenotype-ontology.org" ; owl:versionIRI . hsapdv:end_dpf a owl:AnnotationProperty . hsapdv:end_mpb a owl:AnnotationProperty . hsapdv:end_ypb a owl:AnnotationProperty . hsapdv:start_dpf a owl:AnnotationProperty . hsapdv:start_mpb a owl:AnnotationProperty . hsapdv:start_ypb a owl:AnnotationProperty . a owl:ObjectProperty ; rdfs:label "by_means"@en . a owl:ObjectProperty ; rdfs:label "has-input"@en . a owl:ObjectProperty ; rdfs:label "has_participant"@en . a owl:ObjectProperty ; rdfs:label "in_response_to"@en . a owl:ObjectProperty ; rdfs:label "qualifier"@en . pato:abnormal_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:absent_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:attribute_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:cell_quality a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:disposition_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:hpo_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:location_grouping a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:mpath_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:relational_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:scalar_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pato:seeAlso a owl:AnnotationProperty . pato:value_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . pr:Gene-based a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . pr:PRO-short-label a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . pr:has_constituent_monomer a owl:ObjectProperty . a swrl:Variable . a swrl:Variable . a swrl:Variable . subsets:ro-eco a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:ABBREVIATION a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:COMPARATIVE_PREFERRED a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:DEPRECATED a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:DUBIOUS a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:HOMOLOGY a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:HUMAN_PREFERRED a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:INCONSISTENT a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:LATIN a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:MISSPELLING a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:NON_AMNIOTE a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:NON_MAMMAL a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:PENDING_REVIEW a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:PLURAL a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:SENSU a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:SYSTEMATIC a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . core:anteriorly_connected_to obo:IAO_0000115 "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "anteriorly_connected_to" ; a owl:ObjectProperty ; rdfs:label "anteriorly connected to" ; rdfs:subPropertyOf obo:BSPO_0000099, obo:RO_0002170, core:transitively_anteriorly_connected_to . core:channel_for oboInOwl:hasBroadSynonym "carries" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "channel_for" ; a owl:ObjectProperty ; rdfs:domain obo:UBERON_0004111 ; rdfs:label "channel for" ; rdfs:range obo:UBERON_0000463 . core:channels_from oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "channels_from" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "channels_from" . core:channels_into oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "channels_into" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "channels_into" . core:common_anatomy a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:cumbo a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:cyclostome_subset a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:defined_by_ordinal_series a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:developmental_classification a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:distally_connected_to obo:IAO_0000115 "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "distally_connected_to" ; a owl:ObjectProperty ; rdfs:label "distally connected to" ; rdfs:subPropertyOf obo:BSPO_0000100, obo:RO_0002170, core:transitively_distally_connected_to ; owl:inverseOf core:proximally_connected_to . core:early_development a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:efo_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:emapa_ehdaa2 a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:extends_fibers_into obo:IAO_0000115 "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "extends_fibers_into" ; a owl:ObjectProperty, owl:SymmetricProperty ; rdfs:label "extends_fibers_into" ; rdfs:subPropertyOf obo:RO_0002170 . core:feed_aligned a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:filtered_through obo:IAO_0000115 "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "filtered_through" ; a owl:ObjectProperty ; rdfs:comment "Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed" ; rdfs:label "filtered through" . core:functional_classification a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:grouping_class a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:homology_grouping a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:human_reference_atlas a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:in_innermost_side_of oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_innermost_side_of" ; a owl:ObjectProperty ; rdfs:label "in_innermost_side_of" ; rdfs:subPropertyOf obo:BSPO_0000126 . core:in_outermost_side_of oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "in_outermost_side_of" ; a owl:ObjectProperty ; rdfs:label "in_outermost_side_of" ; rdfs:subPropertyOf obo:BSPO_0000126 . core:inconsistent_with_fma a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:indirectly_supplies obo:IAO_0000115 "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." ; obo:IAO_0000116 "add to RO" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "indirectly_supplies" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "indirectly_supplies" ; owl:propertyChainAxiom (obo:RO_0002569 obo:RO_0002178 ), (obo:RO_0002569 core:indirectly_supplies ) . core:layer_part_of oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "layer_part_of" ; a owl:ObjectProperty ; rdfs:label "layer part of" ; rdfs:subPropertyOf obo:BFO_0000050 . core:location_grouping a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:major_organ a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:non_informative a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:organ_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:pheno_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:phenotype_rcn a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:posteriorly_connected_to obo:IAO_0000115 "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "posteriorly_connected_to" ; a owl:ObjectProperty ; rdfs:label "posteriorly connected to" ; rdfs:subPropertyOf obo:BSPO_0000096, obo:RO_0002170 . core:protects oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "protects" ; a owl:ObjectProperty ; rdfs:label "protects" . core:proximally_connected_to obo:IAO_0000115 "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "proximally_connected_to" ; a owl:ObjectProperty ; rdfs:label "proximally connected to" ; rdfs:subPropertyOf obo:BSPO_0000097, obo:RO_0002170, core:transitively_proximally_connected_to . core:sexually_homologous_to oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "sexually_homologous_to" ; a owl:ObjectProperty ; rdfs:label "sexually_homologous_to" ; rdfs:subPropertyOf obo:RO_0002158 . core:site_of obo:IAO_0000115 "c site_of p if c is the bearer of a disposition that is realized by a process that has p as part." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:hasRelatedSynonym "capable_of_has_part" ; oboInOwl:id "site_of" ; a owl:ObjectProperty ; rdfs:label "site_of" . core:subdivision_of oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "subdivision_of" ; a owl:ObjectProperty ; rdfs:comment "placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B" ; rdfs:label "subdivision of" . core:transitively_anteriorly_connected_to obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "transitively_anteriorly_connected_to" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "transitively anteriorly connected to" . core:transitively_distally_connected_to obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "transitively_distally_connected_to" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "transitively distally connected to" . core:transitively_proximally_connected_to obo:IAO_0000115 "." ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "transitively_proximally_connected_to" ; a owl:ObjectProperty, owl:TransitiveProperty ; rdfs:label "transitively proximally connected to" . core:trunk_part_of oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "trunk_part_of" ; a owl:ObjectProperty ; rdfs:label "trunk_part_of" ; rdfs:subPropertyOf obo:BFO_0000050 . core:uberon_slim a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:unverified_taxonomic_grouping a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:upper_level a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . core:vertebrate_core a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . ubprop:_upper_level a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_annotation_extension a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_gp2term a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_go_ontology a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . obo:valid_for_gocam a owl:AnnotationProperty ; rdfs:subPropertyOf oboInOwl:SubsetProperty . dc:contributor a owl:AnnotationProperty . dc:creator oboInOwl:hasDbXref "http://purl.org/dc/elements/1.1/creator" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dc-creator" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "dc-creator" ; a owl:AnnotationProperty ; rdfs:label "creator" . dc:date a owl:AnnotationProperty . dc:description oboInOwl:hasDbXref "http://purl.org/dc/elements/1.1/description" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dc-description" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "dc-description" ; a owl:AnnotationProperty ; rdfs:label "description" . dc:license a owl:AnnotationProperty . dc:rights a owl:AnnotationProperty . dc:source a owl:AnnotationProperty . dc:subject a owl:AnnotationProperty . dc:title oboInOwl:hasDbXref "http://purl.org/dc/elements/1.1/title" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dc-title" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "dc-title" ; a owl:AnnotationProperty ; rdfs:label "title" . dc:type a owl:AnnotationProperty . dcterms:contributor oboInOwl:hasDbXref "http://purl.org/dc/terms/contributor" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dc-contributor" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "dc-contributor" ; a owl:AnnotationProperty ; rdfs:label "contributor" . dcterms:creator a owl:AnnotationProperty . dcterms:date a owl:AnnotationProperty . dcterms:description a owl:AnnotationProperty . dcterms:license oboInOwl:hasDbXref "http://purl.org/dc/terms/license" ; oboInOwl:hasOBONamespace "uberon" ; oboInOwl:id "dcterms-license" ; oboInOwl:is_metadata_tag true ; oboInOwl:shorthand "dcterms-license" ; a owl:AnnotationProperty ; rdfs:label "license" . dcterms:source a owl:AnnotationProperty . dcterms:title a owl:AnnotationProperty . cito:citesAsAuthority a owl:AnnotationProperty . swrla:isRuleEnabled a owl:AnnotationProperty . oboInOwl:SubsetProperty a owl:AnnotationProperty ; rdfs:label "subset_property" . oboInOwl:SynonymTypeProperty a owl:AnnotationProperty ; rdfs:label "synonym_type_property" . oboInOwl:component a owl:AnnotationProperty . oboInOwl:composition a owl:AnnotationProperty . oboInOwl:conflicts a owl:AnnotationProperty . oboInOwl:consider a owl:AnnotationProperty ; rdfs:label "consider" . oboInOwl:consistent_with a owl:AnnotationProperty . oboInOwl:contradicted_by a owl:AnnotationProperty . oboInOwl:count a owl:AnnotationProperty . oboInOwl:created_by a owl:AnnotationProperty . oboInOwl:creation_date a owl:AnnotationProperty . oboInOwl:date_retrieved a owl:AnnotationProperty . oboInOwl:default-namespace a owl:AnnotationProperty . oboInOwl:editor a owl:AnnotationProperty . oboInOwl:editor_note a owl:AnnotationProperty . oboInOwl:evidence a owl:AnnotationProperty . oboInOwl:exactly a owl:AnnotationProperty . oboInOwl:exception a owl:AnnotationProperty . oboInOwl:exceptions a owl:AnnotationProperty . oboInOwl:exceptions_url a owl:AnnotationProperty . oboInOwl:external_class a owl:AnnotationProperty . oboInOwl:external_class_label a owl:AnnotationProperty . oboInOwl:external_ontology a owl:AnnotationProperty . oboInOwl:gene a owl:AnnotationProperty . oboInOwl:hasAlternativeId a owl:AnnotationProperty ; rdfs:label "has_alternative_id" . oboInOwl:hasBroadSynonym a owl:AnnotationProperty ; rdfs:label "has_broad_synonym" . oboInOwl:hasDbXref a owl:AnnotationProperty ; rdfs:label "database_cross_reference" . oboInOwl:hasExactSynonym a owl:AnnotationProperty ; rdfs:label "has_exact_synonym" . oboInOwl:hasNarrowSynonym a owl:AnnotationProperty ; rdfs:label "has_narrow_synonym" . oboInOwl:hasOBOFormatVersion a owl:AnnotationProperty ; rdfs:label "has_obo_format_version" . oboInOwl:hasOBONamespace a owl:AnnotationProperty . oboInOwl:hasRelatedSynonym a owl:AnnotationProperty ; rdfs:label "has_related_synonym" . oboInOwl:hasScope a owl:AnnotationProperty . oboInOwl:hasSynonymType a owl:AnnotationProperty ; rdfs:label "has_synonym_type" . obo2:IAO_0000232 a owl:AnnotationProperty . oboInOwl:id a owl:AnnotationProperty . oboInOwl:inSubset a owl:AnnotationProperty ; rdfs:label "in_subset" . oboInOwl:inconsistent_with a owl:AnnotationProperty . oboInOwl:inferred_by a owl:AnnotationProperty . oboInOwl:is_entailed a owl:AnnotationProperty . oboInOwl:is_indirect a owl:AnnotationProperty . oboInOwl:is_inferred a owl:AnnotationProperty . oboInOwl:is_metadata_tag a owl:AnnotationProperty . oboInOwl:is_redundant a owl:AnnotationProperty . oboInOwl:logical-definition-view-relation a owl:AnnotationProperty ; rdfs:label "logical-definition-view-relation" . oboInOwl:min_count a owl:AnnotationProperty . oboInOwl:missing_from a owl:AnnotationProperty . oboInOwl:modified_from a owl:AnnotationProperty . oboInOwl:note a owl:AnnotationProperty . oboInOwl:notes a owl:AnnotationProperty . oboInOwl:ontology a owl:AnnotationProperty . oboInOwl:ontology_class a owl:AnnotationProperty . oboInOwl:order a owl:AnnotationProperty . oboInOwl:possible_exception a owl:AnnotationProperty . oboInOwl:proportion a owl:AnnotationProperty . oboInOwl:reference a owl:AnnotationProperty . oboInOwl:saved-by a owl:AnnotationProperty . oboInOwl:seeAlso a owl:AnnotationProperty . oboInOwl:shorthand a owl:AnnotationProperty ; rdfs:label "shorthand" . oboInOwl:source a owl:AnnotationProperty . oboInOwl:specialization_within a owl:AnnotationProperty . oboInOwl:status a owl:AnnotationProperty . oboInOwl:taxon a owl:AnnotationProperty . oboInOwl:taxon_notes a owl:AnnotationProperty . oboInOwl:todo a owl:AnnotationProperty . oboInOwl:treat-xrefs-as-equivalent a owl:AnnotationProperty . oboInOwl:url a owl:AnnotationProperty . oboInOwl:version a owl:AnnotationProperty . oboInOwl:xref a owl:AnnotationProperty . rdfs:comment a owl:AnnotationProperty . rdfs:label a owl:AnnotationProperty . owl:deprecated a owl:AnnotationProperty . skos:closeMatch a owl:AnnotationProperty . foaf:depicted_by a owl:AnnotationProperty . vocab:crossSpeciesExactMatch a owl:AnnotationProperty . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . a swrl:Variable . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002216 ; owl:annotatedTarget (obo:RO_0002215 obo:BFO_0000050 ) . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15705 ; owl:annotatedTarget "L-alpha-amino acids" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57726 ; owl:annotatedTarget "(2R)-pyrrolidinium-2-carboxylate" . [] oboInOwl:hasDbXref "PMID:16018165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100306 ; owl:annotatedTarget "Subsarcolemmal, eosinophilic glass-like regions in the cytoplasm of muscle fibers. Hyaline bodies show significant reactivity to myofibrillar ATPase after acid pre-incubation and with immunohistochemistry, show intense reactivity with only slow myosin heavy chain. Electron microscopy of the affected areas show a lack of myofibrils and a uniform, finely granular matrix, sometimes suggesting a filamentous nature, containing few scattered nuclei and mitochondria." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100306 ; owl:annotatedTarget "Muscle fibre hyaline bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100308 ; owl:annotatedTarget "Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100309 ; owl:annotatedTarget "Subdural haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100309 ; owl:annotatedTarget "Hemorrhage occurring between the dura mater and the arachnoid mater." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100310 ; owl:annotatedTarget "Hemorrhage occurring between the dura mater and the skull." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100310 ; owl:annotatedTarget "Epidural haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100312 ; owl:annotatedTarget "The presence of a germ cell tumor of the cerebrum." . [] oboInOwl:hasDbXref , "PMID:937513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100313 ; owl:annotatedTarget "Cerebral inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100314 ; owl:annotatedTarget "Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57726 ; owl:annotatedTarget "D-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100316 ; owl:annotatedTarget "Intracellular aggregates of actin and actin-associated proteins within nerve cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100317 ; owl:annotatedTarget "Presence of abundant argyrophilic grains and coiled bodies on microscopic examination of brain tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100318 ; owl:annotatedTarget "An intraneuronal inclusion body composed of acid mucopolysaccharides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100319 ; owl:annotatedTarget "Cerebral eosinophilic, discrete, intracytoplasmatic inclusions of unknown significance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100320 ; owl:annotatedTarget "Thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100320 ; owl:annotatedTarget "Rosenthal fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100321 ; owl:annotatedTarget "An abnormality of the dentate nucleus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100322 ; owl:annotatedTarget "Absent pyramidal tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100323 ; owl:annotatedTarget "Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100324 ; owl:annotatedTarget "A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin." . [] oboInOwl:hasDbXref "https://www.st-andrews.ac.uk/~gdk/bl4217web/Gp3%20Ref%20list/hypersensitivity%20printed.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100326 ; owl:annotatedTarget "Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100327 ; owl:annotatedTarget "Hypersensitivity in form of an adverse immune reaction against cow milk protein." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100327 ; owl:annotatedTarget "Cow milk allergy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100327 ; owl:annotatedTarget "Milk allergy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100328 ; owl:annotatedTarget "Fusion involving carpal and metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100328 ; owl:annotatedTarget "Fused wrist bones and long bones of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100329 ; owl:annotatedTarget "Fused bones of the midfoot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100333 ; owl:annotatedTarget "A non-midline cleft of the upper lip on one side only." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100333 ; owl:annotatedTarget "One sided cleft upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100333 ; owl:annotatedTarget "Unilateral cheiloschisis" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100333 ; owl:annotatedTarget "Unilateral cleft upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100334 ; owl:annotatedTarget "One sided cleft palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100334 ; owl:annotatedTarget "Unilateral palatoschisis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100335 ; owl:annotatedTarget "Clefting of the upper lip affecting the lateral portions of the upper lip rather than the midline/median region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100336 ; owl:annotatedTarget "A non-midline cleft of the upper lip on the left and right sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100336 ; owl:annotatedTarget "Bilateral cheiloschisis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100336 ; owl:annotatedTarget "Both sided cleft lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100336 ; owl:annotatedTarget "Right and left cleft lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100337 ; owl:annotatedTarget "Nonmidline cleft palate on the left and right sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100337 ; owl:annotatedTarget "Bilateral palatoschisis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100337 ; owl:annotatedTarget "Right and left cleft palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100338 ; owl:annotatedTarget "Paramedian cleft palate" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57887 ; owl:annotatedTarget "Gmelin:533978" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57887 ; owl:annotatedTarget "2-(1H-indol-3-yl)ethanaminium" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57887 ; owl:annotatedTarget "tryptamine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57887 ; owl:annotatedTarget "tryptaminium cation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57887 ; owl:annotatedTarget "tryptaminium(1+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100348 ; owl:annotatedTarget "The proximal interphalangeal joint of the 2nd toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100349 ; owl:annotatedTarget "The proximal interphalangeal joint of the 3rd toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100350 ; owl:annotatedTarget "The proximal interphalangeal joint of the 4th toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100350 ; owl:annotatedTarget "Contracture of the innermost hinge joint of the 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57947 ; owl:annotatedTarget "creatine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100351 ; owl:annotatedTarget "The proximal interphalangeal joint of the fifth toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57947 ; owl:annotatedTarget "{[amino(iminio)methyl](methyl)amino}acetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100352 ; owl:annotatedTarget "The distal interphalangeal joint of the 2nd toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57948 ; owl:annotatedTarget "(2R)-5-oxopyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100353 ; owl:annotatedTarget "The distal interphalangeal joint of the 3rd toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57948 ; owl:annotatedTarget "5-oxo-D-prolinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100354 ; owl:annotatedTarget "The distal interphalangeal joint of the 4th toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57948 ; owl:annotatedTarget "5-oxo-D-prolinate anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100355 ; owl:annotatedTarget "The distal interphalangeal joint of the 5th toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100355 ; owl:annotatedTarget "Contracture of the outermost hinge joint of the 5th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57948 ; owl:annotatedTarget "5-oxo-D-prolinate(1-)" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57948 ; owl:annotatedTarget "5-oxo-D-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100356 ; owl:annotatedTarget "The joint between the second metatarsal and the proximal phalanx of the 2nd toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100357 ; owl:annotatedTarget "The joint between the third metatarsal and the proximal phalanx of the third toe cannot be straightened actively or passively." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57966 ; owl:annotatedTarget "Gmelin:454332" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100358 ; owl:annotatedTarget "The joint between the fourth metatarsal and the proximal phalanx of the fourth toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57966 ; owl:annotatedTarget "3-azaniumylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100359 ; owl:annotatedTarget "The joint between the fifth metatarsal and the proximal phalanx of the fifth toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57966 ; owl:annotatedTarget "3-ammoniopropanoate" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57966 ; owl:annotatedTarget "beta-alanine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100362 ; owl:annotatedTarget "Absent digital bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100363 ; owl:annotatedTarget "Absent bones of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100364 ; owl:annotatedTarget "Absent little toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100364 ; owl:annotatedTarget "Absent pinkie toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100364 ; owl:annotatedTarget "Absent pinky toe bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57977 ; owl:annotatedTarget "Beilstein:4083310" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100366 ; owl:annotatedTarget "Developmental hypoplasia of the phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100366 ; owl:annotatedTarget "Short 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57977 ; owl:annotatedTarget "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100367 ; owl:annotatedTarget "Developmental hypoplasia of one or more phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100367 ; owl:annotatedTarget "Short 4th toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100368 ; owl:annotatedTarget "Developmental hypoplasia of one or more phalanx of little toe." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57977 ; owl:annotatedTarget "bilirubin IXalpha" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100368 ; owl:annotatedTarget "Short little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100368 ; owl:annotatedTarget "Short pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100368 ; owl:annotatedTarget "Short pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57977 ; owl:annotatedTarget "bilirubin dianion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100369 ; owl:annotatedTarget "Absent/small outermost 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100369 ; owl:annotatedTarget "Absent/underdeveloped outermost 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100370 ; owl:annotatedTarget "Absent/small outermost bone of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100370 ; owl:annotatedTarget "Absent/underdeveloped outermost bone of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100371 ; owl:annotatedTarget "Absent/small outermost little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100371 ; owl:annotatedTarget "Absent/small outermost pinkie toe bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58001 ; owl:annotatedTarget "an aliphatic amine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100371 ; owl:annotatedTarget "Absent/small outermost pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100371 ; owl:annotatedTarget "Absent/underdeveloped outermost pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100372 ; owl:annotatedTarget "Absent/small middle 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58001 ; owl:annotatedTarget "primary aliphatic ammonium cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100372 ; owl:annotatedTarget "Absent/underdeveloped middle 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100373 ; owl:annotatedTarget "Absent/small middle bone of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100373 ; owl:annotatedTarget "Absent/underdeveloped middle bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58001 ; owl:annotatedTarget "primary aliphatic ammonium cations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100374 ; owl:annotatedTarget "Absent/small middle 5th toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100374 ; owl:annotatedTarget "Absent/underdeveloped middle bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100374 ; owl:annotatedTarget "Absent/underdeveloped middle bone of pinkie toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58001 ; owl:annotatedTarget "primary aliphatic ammonium ions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100374 ; owl:annotatedTarget "Absent/underdeveloped middle bone of pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100375 ; owl:annotatedTarget "Absence (agenesis) or underdevelopment of the proximal phalanx of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100375 ; owl:annotatedTarget "Absent/small innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100375 ; owl:annotatedTarget "Absent/underdeveloped innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100376 ; owl:annotatedTarget "Absence (agenesis) or underdevelopment of the proximal phalanx of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100376 ; owl:annotatedTarget "Absent/small innermost 4th toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58048 ; owl:annotatedTarget "(2S)-4-amino-2-azaniumyl-4-oxobutanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100376 ; owl:annotatedTarget "Absent/underdeveloped innermost 4th toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100377 ; owl:annotatedTarget "Absence (agenesis) or underdevelopment of the proximal phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100377 ; owl:annotatedTarget "Absent/small innermost little toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58048 ; owl:annotatedTarget "(2S)-2-ammonio-3-carbamoylpropanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100377 ; owl:annotatedTarget "Absent/small innermost pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100377 ; owl:annotatedTarget "Absent/small innermost pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100377 ; owl:annotatedTarget "Absent/underdeveloped innermost 5th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58048 ; owl:annotatedTarget "(2S)-2-azaniumyl-3-carbamoylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100378 ; owl:annotatedTarget "Developmental aplasia of the distal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100378 ; owl:annotatedTarget "Absent outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100379 ; owl:annotatedTarget "Absent distal phalanx of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58048 ; owl:annotatedTarget "(2S)-4-amino-2-ammonio-4-oxobutanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100379 ; owl:annotatedTarget "Absent outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100380 ; owl:annotatedTarget "Absent outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100380 ; owl:annotatedTarget "Absent outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58048 ; owl:annotatedTarget "L-asparagine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100380 ; owl:annotatedTarget "Absent outermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100381 ; owl:annotatedTarget "Developmental aplasia of the middle phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100381 ; owl:annotatedTarget "Absent middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100382 ; owl:annotatedTarget "Absent middle bone of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100383 ; owl:annotatedTarget "Absent middle bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100383 ; owl:annotatedTarget "Absent middle bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100383 ; owl:annotatedTarget "Absent middle bone of pinky toe" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "PMID:10850983" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100384 ; owl:annotatedTarget "Absence of proximal phalanx of third toe, owing to a congenital defect of development." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100384 ; owl:annotatedTarget "Absent innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-2-hydroxy monocarboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100385 ; owl:annotatedTarget "Absent innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-2-hydroxy monocarboxylates" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100386 ; owl:annotatedTarget "Absent innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100386 ; owl:annotatedTarget "Absent innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100386 ; owl:annotatedTarget "Absent innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-2-hydroxy monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100387 ; owl:annotatedTarget "Absent middle toe bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-2-hydroxycarboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100388 ; owl:annotatedTarget "Absent innermost toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100389 ; owl:annotatedTarget "Developmental hypoplasia of the distal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100389 ; owl:annotatedTarget "Short outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-alpha-hydroxy monocarboxylic acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100390 ; owl:annotatedTarget "Developmental hypoplasia of the distal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100390 ; owl:annotatedTarget "Short outermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(2S)-alpha-hydroxy monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100391 ; owl:annotatedTarget "Developmental hypoplasia of the distal phalanx of little toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100391 ; owl:annotatedTarget "Short outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100391 ; owl:annotatedTarget "Short outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100391 ; owl:annotatedTarget "Short outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(S)-2-hydroxyacid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100392 ; owl:annotatedTarget "Developmental hypoplasia of the middle phalanx of third toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "(S)-2-hydroxyacid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100393 ; owl:annotatedTarget "Developmental hypoplasia of the middle phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100393 ; owl:annotatedTarget "Short middle bone of 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58123 ; owl:annotatedTarget "a (2S)-2-hydroxycarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100394 ; owl:annotatedTarget "Developmental hypoplasia of the middle phalanx of the 5th toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100394 ; owl:annotatedTarget "Hypoplastic/small middle phalanx of the 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100394 ; owl:annotatedTarget "Short middle bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100394 ; owl:annotatedTarget "Short middle bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100394 ; owl:annotatedTarget "Short middle bone of pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100395 ; owl:annotatedTarget "Abnormal reduction in length of proximal phalanx of third toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100396 ; owl:annotatedTarget "Developmental hypoplasia of the proximal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Developmental hypoplasia of the proximal phalanx of fifth toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Hypoplastic/small proximal phalanx of the 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Short innermost bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Short innermost bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Short innermost bone of pinky toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100397 ; owl:annotatedTarget "Short proximal phalanx of the fifth toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100398 ; owl:annotatedTarget "Partial or complete duplication of distal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100398 ; owl:annotatedTarget "Duplication of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58126 ; owl:annotatedTarget "3-[5-(azaniumylmethyl)-4-(carboxylatomethyl)-1H-pyrrol-3-yl]propanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100399 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100399 ; owl:annotatedTarget "Duplication of the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100400 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of little toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100400 ; owl:annotatedTarget "Duplication of the outermost bone of the fifth toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100400 ; owl:annotatedTarget "Duplication of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100400 ; owl:annotatedTarget "Duplication of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100400 ; owl:annotatedTarget "Duplication of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100401 ; owl:annotatedTarget "Partial or complete duplication of middle phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100401 ; owl:annotatedTarget "Duplication of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100402 ; owl:annotatedTarget "Partial or complete duplication of middle phalanx of fourth toe." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58126 ; owl:annotatedTarget "porphobilinogen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100402 ; owl:annotatedTarget "Duplication of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100403 ; owl:annotatedTarget "Partial or complete duplication of the middle phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100403 ; owl:annotatedTarget "Duplication of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100403 ; owl:annotatedTarget "Duplication of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100403 ; owl:annotatedTarget "Duplication of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100404 ; owl:annotatedTarget "Partial or complete duplication of proximal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100404 ; owl:annotatedTarget "Duplication of the innermost 3rd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100405 ; owl:annotatedTarget "Partial or complete duplication of the proximal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100405 ; owl:annotatedTarget "Duplication of the innermost 4th toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100406 ; owl:annotatedTarget "Partial or complete duplication of the proximal phalanx of fifth toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58126 ; owl:annotatedTarget "porphobilinogen anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100406 ; owl:annotatedTarget "Duplication of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100406 ; owl:annotatedTarget "Duplication of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100406 ; owl:annotatedTarget "Duplication of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100407 ; owl:annotatedTarget "Complete duplication of distal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100407 ; owl:annotatedTarget "Complete duplication of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100408 ; owl:annotatedTarget "Complete duplication of the distal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100408 ; owl:annotatedTarget "Complete duplication of the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100409 ; owl:annotatedTarget "Complete duplication of the distal phalanx of little toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100409 ; owl:annotatedTarget "Complete duplication of the outermost bone of the little toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58163 ; owl:annotatedTarget "4,4'-disulfanediylbis(2-azaniumylbutanoate)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100409 ; owl:annotatedTarget "Complete duplication of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100409 ; owl:annotatedTarget "Complete duplication of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100410 ; owl:annotatedTarget "Complete duplication of middle phalanx of third toe." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58163 ; owl:annotatedTarget "4,4'-disulfanediylbis(2-ammoniobutanoate)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100410 ; owl:annotatedTarget "Complete duplication of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100411 ; owl:annotatedTarget "Complete duplication of middle phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100411 ; owl:annotatedTarget "Complete duplication of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58163 ; owl:annotatedTarget "homocystine dizwitterion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100412 ; owl:annotatedTarget "Complete duplication of the middle phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100412 ; owl:annotatedTarget "Complete duplication of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100412 ; owl:annotatedTarget "Complete duplication of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100412 ; owl:annotatedTarget "Complete duplication of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100413 ; owl:annotatedTarget "Complete duplication of proximal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100413 ; owl:annotatedTarget "Complete duplication of the innermost 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100414 ; owl:annotatedTarget "Complete duplication of the innermost 4th toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100415 ; owl:annotatedTarget "Complete duplication of the proximal phalanx of fifth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100415 ; owl:annotatedTarget "Complete duplication of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100415 ; owl:annotatedTarget "Complete duplication of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100415 ; owl:annotatedTarget "Complete duplication of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100416 ; owl:annotatedTarget "Partial duplication of distal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100416 ; owl:annotatedTarget "Partial duplication of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100417 ; owl:annotatedTarget "Partial duplication of the distal phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100417 ; owl:annotatedTarget "Partial duplication of the outermost bone of the fourth toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100418 ; owl:annotatedTarget "Partial duplication of the distal phalanx of little toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(2R)-2-hydroxy monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100418 ; owl:annotatedTarget "Partial duplication of the outermost bone of the fifth toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100418 ; owl:annotatedTarget "Partial duplication of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100418 ; owl:annotatedTarget "Partial duplication of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100418 ; owl:annotatedTarget "Partial duplication of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100419 ; owl:annotatedTarget "Partial duplication of middle phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100419 ; owl:annotatedTarget "Partial duplication of the middle bone of 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100420 ; owl:annotatedTarget "Partial duplication of middle phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100420 ; owl:annotatedTarget "Partial duplication of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100421 ; owl:annotatedTarget "Partial duplication of the middle phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100421 ; owl:annotatedTarget "Partial duplication of the middle bone of the little toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(2R)-2-hydroxycarboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100421 ; owl:annotatedTarget "Partial duplication of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100421 ; owl:annotatedTarget "Partial duplication of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100422 ; owl:annotatedTarget "Partial duplication of proximal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100422 ; owl:annotatedTarget "Partial duplication of the innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100423 ; owl:annotatedTarget "Partial duplication of the innermost bone of 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100424 ; owl:annotatedTarget "Partial duplication of the proximal phalanx of fifth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100424 ; owl:annotatedTarget "Partial duplication of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100424 ; owl:annotatedTarget "Partial duplication of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100424 ; owl:annotatedTarget "Partial duplication of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(2R)-alpha-hydroxy monocarboxylic acid anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100425 ; owl:annotatedTarget "Broad middle 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(2R)-alpha-hydroxy monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100426 ; owl:annotatedTarget "Broad middle 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(R)-2-hydroxyacid anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100427 ; owl:annotatedTarget "Broad middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100427 ; owl:annotatedTarget "Broad middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100427 ; owl:annotatedTarget "Broad middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "(R)-2-hydroxyacid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100428 ; owl:annotatedTarget "Wide innermost bone of 3rd toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58314 ; owl:annotatedTarget "a (2R)-2-hydroxycarboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100429 ; owl:annotatedTarget "Wide innermost bone of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100430 ; owl:annotatedTarget "Broad innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100430 ; owl:annotatedTarget "Broad innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100430 ; owl:annotatedTarget "Broad innermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100431 ; owl:annotatedTarget "Broad outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100431 ; owl:annotatedTarget "Wide outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58375 ; owl:annotatedTarget "(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100432 ; owl:annotatedTarget "Broad outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100432 ; owl:annotatedTarget "Wide outermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58375 ; owl:annotatedTarget "hydroxyproline zwitterion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100433 ; owl:annotatedTarget "Broad outermost bone of the 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100433 ; owl:annotatedTarget "Wide outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100433 ; owl:annotatedTarget "Wide outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100433 ; owl:annotatedTarget "Wide outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58375 ; owl:annotatedTarget "trans-4-hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100434 ; owl:annotatedTarget "An abnormal morphology of the middle phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100434 ; owl:annotatedTarget "Bullet-shaped middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100435 ; owl:annotatedTarget "An abnormal morphology of the middle phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100435 ; owl:annotatedTarget "Bullet-shaped middle bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100436 ; owl:annotatedTarget "An abnormal morphology of the middle phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100436 ; owl:annotatedTarget "Bullet-shaped middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100436 ; owl:annotatedTarget "Bullet-shaped middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100436 ; owl:annotatedTarget "Bullet-shaped middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100437 ; owl:annotatedTarget "An abnormal morphology of the proximal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100437 ; owl:annotatedTarget "Bullet-shaped proximal bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100438 ; owl:annotatedTarget "An abnormal morphology of the proximal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100438 ; owl:annotatedTarget "Bullet-shaped proximal bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100439 ; owl:annotatedTarget "An abnormal morphology of the proximal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100439 ; owl:annotatedTarget "Bullet-shaped innermost bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100439 ; owl:annotatedTarget "Bullet-shaped innermost bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100439 ; owl:annotatedTarget "Bullet-shaped innermost bone of pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100440 ; owl:annotatedTarget "An abnormal morphology of the distal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100440 ; owl:annotatedTarget "Bullet-shaped outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100441 ; owl:annotatedTarget "An abnormal morphology of the distal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100441 ; owl:annotatedTarget "Bullet-shaped outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100442 ; owl:annotatedTarget "An abnormal morphology of the distal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100442 ; owl:annotatedTarget "Bullet-shaped outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100442 ; owl:annotatedTarget "Bullet-shaped outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100442 ; owl:annotatedTarget "Bullet-shaped outermost bone of the pinky toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "Reaxys:16709444" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100443 ; owl:annotatedTarget "A deviation from the normal straight form of the middle phalanx of the third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100443 ; owl:annotatedTarget "Curved middle bone of 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "N,N-dimethylmethanaminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100444 ; owl:annotatedTarget "A deviation from the normal straight form of the middle phalanx of the fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100444 ; owl:annotatedTarget "Curved middle bone of 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100445 ; owl:annotatedTarget "A deviation from the normal straight form of the middle phalanx of the fifth toe." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "trimethylamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100445 ; owl:annotatedTarget "Curved middle bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100445 ; owl:annotatedTarget "Curved middle bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100445 ; owl:annotatedTarget "Curved middle bone of pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "trimethylammonium cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100446 ; owl:annotatedTarget "A deviation from the normal straight form of the proximal phalanx of the third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100446 ; owl:annotatedTarget "Curved innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100447 ; owl:annotatedTarget "A deviation from the normal straight form of the proximal phalanx of the fourth toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "trimethylazanium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100447 ; owl:annotatedTarget "Curved innermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100448 ; owl:annotatedTarget "A deviation from the normal straight form of the proximal phalanx of the fifth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100448 ; owl:annotatedTarget "Curved innermost little toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58389 ; owl:annotatedTarget "trimethylazanium cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100448 ; owl:annotatedTarget "Curved innermost pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100448 ; owl:annotatedTarget "Curved innermost pinky toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100449 ; owl:annotatedTarget "A deviation from the normal straight form of the distal phalanx of the third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100449 ; owl:annotatedTarget "Curved outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100450 ; owl:annotatedTarget "A deviation from the normal straight form of the distal phalanx of the fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100450 ; owl:annotatedTarget "Curved outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100451 ; owl:annotatedTarget "A deviation from the normal straight form of the distal phalanx of the fifth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100451 ; owl:annotatedTarget "Curved outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100451 ; owl:annotatedTarget "Curved outermost bone of the pinkie toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_58402 ; owl:annotatedTarget "Beilstein:4783230" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100451 ; owl:annotatedTarget "Curved outermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100458 ; owl:annotatedTarget "Osteolytic defects of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100459 ; owl:annotatedTarget "Osteolytic defects of the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100460 ; owl:annotatedTarget "Osteolytic defects of the outermost bone of the 5th toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_58402 ; owl:annotatedTarget "Gmelin:675391" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100461 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58402 ; owl:annotatedTarget "(2S)-5-oxopyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58402 ; owl:annotatedTarget "5-oxo-L-prolate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100462 ; owl:annotatedTarget "Uneven increase in bone density of the middle phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100462 ; owl:annotatedTarget "Uneven increase in bone density in middle bone of the 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58402 ; owl:annotatedTarget "5-oxo-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100463 ; owl:annotatedTarget "Uneven increase in bone density of the middle phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100463 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100463 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100463 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100464 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_58419 ; owl:annotatedTarget "(2S)-4-hydroxypyrrolidinium-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100465 ; owl:annotatedTarget "Uneven increase in bone density of the proximal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100465 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58419 ; owl:annotatedTarget "4-hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100466 ; owl:annotatedTarget "Uneven increase in bone density of the proximal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100466 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100466 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100466 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58465 ; owl:annotatedTarget "dermatan 4'-sulfate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100467 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58945 ; owl:annotatedTarget "organophosphate oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100468 ; owl:annotatedTarget "Uneven increase in bone density of the distal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100468 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58951 ; owl:annotatedTarget "a short-chain fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100469 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of the distal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100469 ; owl:annotatedTarget "Uneven increase in bone density in the outermost little toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58951 ; owl:annotatedTarget "short-chain fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100469 ; owl:annotatedTarget "Uneven increase in bone density in the outermost pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100469 ; owl:annotatedTarget "Uneven increase in bone density in the outermost pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100470 ; owl:annotatedTarget "Fused middle bones of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100471 ; owl:annotatedTarget "Fused middle bones of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100472 ; owl:annotatedTarget "Fused middle bones of 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100473 ; owl:annotatedTarget "Fused innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100474 ; owl:annotatedTarget "Fused innermost bones of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100475 ; owl:annotatedTarget "Fused innermost bone of little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100475 ; owl:annotatedTarget "Fused innermost bone of pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100475 ; owl:annotatedTarget "Fused innermost bone of pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58953 ; owl:annotatedTarget "saturated fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100476 ; owl:annotatedTarget "Fused outermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100477 ; owl:annotatedTarget "Fused outermost bone of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100478 ; owl:annotatedTarget "Fused outermost bones of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100478 ; owl:annotatedTarget "Fused outermost bones of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100478 ; owl:annotatedTarget "Fused outermost bones of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100480 ; owl:annotatedTarget "Bony fusion of the middle and proximal phalanges of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100480 ; owl:annotatedTarget "Fused innermost and middle bones of 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100481 ; owl:annotatedTarget "Bony fusion of the middle and proximal phalanges of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100481 ; owl:annotatedTarget "Fused innermost and middle bones of 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100482 ; owl:annotatedTarget "Bony fusion of the middle and proximal phalanges of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100482 ; owl:annotatedTarget "Fused innermost and middle little toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100482 ; owl:annotatedTarget "Fused innermost and middle pinkie toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100482 ; owl:annotatedTarget "Fused innermost and middle pinky toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100483 ; owl:annotatedTarget "Fused innermost bone of 2nd toe with the 2nd long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100484 ; owl:annotatedTarget "Fused innermost bones of third toe with 3rd long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100485 ; owl:annotatedTarget "Fused innermost bone of the 4th toe with 4th long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100486 ; owl:annotatedTarget "Fused innermost pinky toe bone with the 5th long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100487 ; owl:annotatedTarget "Triangular shaped outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100487 ; owl:annotatedTarget "Triangular shaped outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100487 ; owl:annotatedTarget "Triangular shaped outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58954 ; owl:annotatedTarget "straight-chain saturated fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100488 ; owl:annotatedTarget "Fusion of the innermost big toe bone with the 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100489 ; owl:annotatedTarget "Bony fusion of the middle and proximal phalanges of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100489 ; owl:annotatedTarget "Fused middle and innermost bones of 2nd toe" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100490 ; owl:annotatedTarget "The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers cannot be extended to 180 degrees by either active or passive extension." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100490 ; owl:annotatedTarget "Permanent flexion of the finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100491 ; owl:annotatedTarget "Abnormality of lower limb joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100491 ; owl:annotatedTarget "Abnormality of the joints of the lower limbs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58955 ; owl:annotatedTarget "branched-chain fatty acid anions" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100493 ; owl:annotatedTarget "A decreased concentration of ammonia in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100494 ; owl:annotatedTarget "Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:10951105" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58956 ; owl:annotatedTarget "branched-chain saturated fatty acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100495 ; owl:annotatedTarget "The presence of an increased number of mast cells and CD34+ mast cell precursors in the body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100496 ; owl:annotatedTarget "Abnormality of the vitamin B3 metabolism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100497 ; owl:annotatedTarget "Vitamin B3 deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100501 ; owl:annotatedTarget "An increased susceptibility to bronchiolitis as manifested by a history of recurrent bronchiolitis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100502 ; owl:annotatedTarget "Vitamin B12 deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100503 ; owl:annotatedTarget "Vitamin B1 deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100504 ; owl:annotatedTarget "Vitamin B2 deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100505 ; owl:annotatedTarget "Vitamin B5 deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100506 ; owl:annotatedTarget "Vitamin B8 deficiency" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_58958 ; owl:annotatedTarget "organosulfate oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100507 ; owl:annotatedTarget "A reduced circulating concentration of folic acid, which is also known as vitamin B9." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100507 ; owl:annotatedTarget "Folate deficiency" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59132 ; owl:annotatedTarget "antigens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100508 ; owl:annotatedTarget "An anomaly in the metabolism of a vitamin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100508 ; owl:annotatedTarget "Abnormality of vitamin metabolism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59163 ; owl:annotatedTarget "biological marker" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100509 ; owl:annotatedTarget "Abnormality of vitamin C metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "PMID:17875790" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100510 ; owl:annotatedTarget "Vitamin C deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100511 ; owl:annotatedTarget "Abnormality of vitamin D metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "PMID:17986299" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100512 ; owl:annotatedTarget "Deficient in vitamin D" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100512 ; owl:annotatedTarget "Vitamin D deficiency" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "PMID:19101624" . [] oboInOwl:hasDbXref "PMID:30559825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100513 ; owl:annotatedTarget "A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100513 ; owl:annotatedTarget "Alpha-tocopherol deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100513 ; owl:annotatedTarget "Vitamin E deficiency" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "PMID:291959" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100515 ; owl:annotatedTarget "Increased frequency of urination." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100515 ; owl:annotatedTarget "Constant urination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100515 ; owl:annotatedTarget "Frequent urination" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100516 ; owl:annotatedTarget "The presence of a neoplasm of the ureter." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:10951108" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "PMID:3782019" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100517 ; owl:annotatedTarget "The presence of a neoplasm of the urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100518 ; owl:annotatedTarget "Painful or difficult urination." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100518 ; owl:annotatedTarget "Painful or difficult urination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100518 ; owl:annotatedTarget "Dull burning sensation with urination" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59174 ; owl:annotatedTarget "haptens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100519 ; owl:annotatedTarget "Absence of urine, clinically classified as below 50ml/day." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100519 ; owl:annotatedTarget "Absent urine output" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100520 ; owl:annotatedTarget "Low output of urine, clinically classified as an output below 300-500ml/day." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100521 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the thymus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100522 ; owl:annotatedTarget "A tumor originating from the epithelial cells of the thymus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100523 ; owl:annotatedTarget "The presence of an abscess of the liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100523 ; owl:annotatedTarget "Liver abscess" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59202 ; owl:annotatedTarget "straight-chain fatty acids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100524 ; owl:annotatedTarget "Limb duplication" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100525 ; owl:annotatedTarget "Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100526 ; owl:annotatedTarget "Tumor of the lung." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59203 ; owl:annotatedTarget "straight-chain FA anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100526 ; owl:annotatedTarget "Lung cancer" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100526 ; owl:annotatedTarget "Lung tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100526 ; owl:annotatedTarget "Lung tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100528 ; owl:annotatedTarget "A rare cancer originating in the lung or pleural cavity that occurs most often in infants and young children but also has been reported in adults. Pleuropulmonary blastoma is regarded as malignant." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59203 ; owl:annotatedTarget "straight-chain FA anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100529 ; owl:annotatedTarget "An abnormality of phosphate homeostasis or concentration in the body." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100530 ; owl:annotatedTarget "Abnormal Ca-PHOS regulating hormone level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100530 ; owl:annotatedTarget "Abnormal Ca2+ PO4 regulating hormone level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100531 ; owl:annotatedTarget "The appearance of abnormal valgus deformity in one knee in association with varus deformity in the other." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100531 ; owl:annotatedTarget "Wind-swept deformity of the knees" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100532 ; owl:annotatedTarget "Inflammation of the sclera." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100532 ; owl:annotatedTarget "Inflammation of the outer white part of the eye" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59203 ; owl:annotatedTarget "straight-chain fatty acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100533 ; owl:annotatedTarget "Inflammation of the eye, parts of the eye or the periorbital region." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100533 ; owl:annotatedTarget "Inflammatory abnormality of the eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100534 ; owl:annotatedTarget "Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100534 ; owl:annotatedTarget "Inflammation of the thin layer on top of the white part of eye" . ( ) . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100536 ; owl:annotatedTarget "An abnormality of fascia." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:11470131" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "Beilstein:4632263" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0100537 ; owl:annotatedTarget _:genid101287 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100537 ; owl:annotatedTarget "Inflammation of fascia, the tissue under the skin and over the muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100537 ; owl:annotatedTarget "Inflammation of the fascia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "An anomaly of the supraorbital portion of the frontal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "Abnormality of the brow of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "Deformity of the supraorbital margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "Deformity of the supraorbital ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "Malformation of the supraorbital margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100538 ; owl:annotatedTarget "Malformation of the supraorbital ridges" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:11164910" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100539 ; owl:annotatedTarget "Edema affecting the region situated around the orbit of the eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100539 ; owl:annotatedTarget "Periorbital cellulitis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100539 ; owl:annotatedTarget "Periorbital oedema" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:12058986" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Edema in the region of the eyelids." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Eyelid oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Fullness of eyelids" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:12950597" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Oedema of the eyelids" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Palpebral oedema" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Puffy eyelids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Puffy lids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100540 ; owl:annotatedTarget "Swelling of eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100541 ; owl:annotatedTarget "A hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal." . [] a owl:Axiom ; rdfs:label "Femoral hernia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100541 ; owl:annotatedTarget "MEDDRA:10016434" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:14613940" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100542 ; owl:annotatedTarget "An abnormal site of the kidney." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100542 ; owl:annotatedTarget "Abnormal localisation of kidneys" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:15179041" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Abnormal cognition with deficits in thinking, reasoning, or remembering." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Abnormality of cognition" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Cognitive abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Cognitive defects" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Cognitive deficits" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Cognitive impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100543 ; owl:annotatedTarget "Intellectual impairment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:19443021" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100544 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the heart." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100544 ; owl:annotatedTarget "Heart tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100544 ; owl:annotatedTarget "Heart tumour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:24027187" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100545 ; owl:annotatedTarget "Narrowing or constriction of the inner surface (lumen) of an artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100545 ; owl:annotatedTarget "Narrowing of an artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100546 ; owl:annotatedTarget "Narrowing of the carotid arteries." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100546 ; owl:annotatedTarget "Narrowing of carotid artery" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:25568069" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100547 ; owl:annotatedTarget "An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100547 ; owl:annotatedTarget "Abnormal shape of forebrain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100548 ; owl:annotatedTarget "Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall." . [] oboInOwl:hasDbXref , "PMID:27047816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100550 ; owl:annotatedTarget "Breakage (tear) of a tendon." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100550 ; owl:annotatedTarget "Rupture of tendons" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100550 ; owl:annotatedTarget "Ruptured tendon" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100550 ; owl:annotatedTarget "Tendon rupture" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:3142362" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100553 ; owl:annotatedTarget "Overgrowth of only one leg." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100553 ; owl:annotatedTarget "Overgrowth of one leg" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:11707898" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:31537530" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100554 ; owl:annotatedTarget "Overgrowth of only one arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100554 ; owl:annotatedTarget "Overgrowth of one arm" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:33164488" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100555 ; owl:annotatedTarget "A growth pattern that displays an abnormal difference between the left and the right side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100555 ; owl:annotatedTarget "Uneven or disproportionate growth of one body part compared to another" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:3768140" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100556 ; owl:annotatedTarget "Undergrowth of the limbs that affects only one side." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100556 ; owl:annotatedTarget "Asymmetric limb shortening" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:510308" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100557 ; owl:annotatedTarget "Unilateral atrophy (reduction in size) of a leg." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:599156" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100557 ; owl:annotatedTarget "Asymmetric lower limb shortening" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:6672002" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100558 ; owl:annotatedTarget "Unilateral atrophy (reduction in size) of an arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100558 ; owl:annotatedTarget "Asymmetric upper limb shortening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100559 ; owl:annotatedTarget "A difference in length or diameter between the left and right leg." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:7507746" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100559 ; owl:annotatedTarget "Left and right leg differ in length or width" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100559 ; owl:annotatedTarget "Leg length discrepancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100560 ; owl:annotatedTarget "Difference in length or size between the right and left arm." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "PMID:7706301" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100560 ; owl:annotatedTarget "Unequal size of arms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100562 ; owl:annotatedTarget "Duplication of the spinal cord." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100562 ; owl:annotatedTarget "Duplication of spinal cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100563 ; owl:annotatedTarget "Coexistence of two hemicords, at variable levels, causing splaying of the posterior vertebral elements. Results in neurological deficits in lower limb or perineum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100564 ; owl:annotatedTarget "Triplication of the spinal cord - extremely rare." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100564 ; owl:annotatedTarget "Triplication of spinal cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100565 ; owl:annotatedTarget "Dilation of central canal from incomplete fusion of the posterior columns or persistence of the primitive large canal of the embryo." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100566 ; owl:annotatedTarget "Congenital absence of the spinal cord." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100566 ; owl:annotatedTarget "Absent spinal cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100568 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the endocrine system." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "Reaxys:4632263" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "(6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100569 ; owl:annotatedTarget "An abnormality of the formation and mineralization of one or more vertebrae." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100569 ; owl:annotatedTarget "Abnormal bone maturation of vertebra" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100570 ; owl:annotatedTarget "A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100570 ; owl:annotatedTarget "Carcinoid tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100570 ; owl:annotatedTarget "Carcinoid tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100570 ; owl:annotatedTarget "Carcinoid tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100571 ; owl:annotatedTarget "A cardiac diverticulum is a rare congenital malformation which is either fibrous or muscular." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100572 ; owl:annotatedTarget "A fibrous cardiac diverticulum refers to an aneurysm and usually appears as an isolated congenital anomaly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100574 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the biliary system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:11911459" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100575 ; owl:annotatedTarget "The presence of a neoplasm of the gallbladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100576 ; owl:annotatedTarget "A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100577 ; owl:annotatedTarget "Inflammation of the urinary bladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100577 ; owl:annotatedTarget "Urinary bladder inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100578 ; owl:annotatedTarget "Localized loss of fat tissue." . [] a owl:Axiom ; rdfs:label "Lipoatrophy" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100578 ; owl:annotatedTarget "MEDDRA:10024604" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100578 ; owl:annotatedTarget "Atrophy of fat" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100578 ; owl:annotatedTarget "Loss of fat tissue in localised area" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100578 ; owl:annotatedTarget "Loss of fat tissue in localized area" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "(2->3')-a-Sialyllactose" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "(2->3')-alpha-Sialyllactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100579 ; owl:annotatedTarget "Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100580 ; owl:annotatedTarget "An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100580 ; owl:annotatedTarget "Barret syndrome" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100580 ; owl:annotatedTarget "Barrett oesophagus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100580 ; owl:annotatedTarget "Barrett's oesophagus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100581 ; owl:annotatedTarget "An abnormal enlargement of the renal calices, the system of ducts of the kidney that collect urine." . [] oboInOwl:hasDbXref , "PMID:18728843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100582 ; owl:annotatedTarget "Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100582 ; owl:annotatedTarget "Polyps of nose" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "(2S,4S,5R,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100583 ; owl:annotatedTarget "A rupture of the cornea through which a portion of the iris protrudes." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-(N-Acetyl-a-neuraminosyl)lactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100584 ; owl:annotatedTarget "An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100585 ; owl:annotatedTarget "Presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-(N-Acetyl-alpha-neuraminosyl)lactose" . [] oboInOwl:hasDbXref , "PMID:25760357", "PMID:26425144", "PMID:26917663" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100586 ; owl:annotatedTarget "Patients who routinely have greater than 20 leukocytes per microliter, but have abacterial urine, are said to have sterile pyuria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100588 ; owl:annotatedTarget "The foreskin becomes trapped behind the glans penis, and cannot be pulled back to its normal flaccid position covering the glans penis." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-Monosialyllactose" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-N-Acetylneuraminyl-D-lactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100589 ; owl:annotatedTarget "The presence of a fistula affecting the genitourinary system." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-N-Acetylneuraminyl-delta-lactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100590 ; owl:annotatedTarget "The presence of a fistula affecting the rectum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:11976203" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-Sialyl-D-lactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100592 ; owl:annotatedTarget "The presence of an abscess of the peritoneum." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-Sialyl-delta-lactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100594 ; owl:annotatedTarget "Thin (2-3mm) membranes of normal esophageal tissue consisting of mucosa and submucosa that can be congenital or acquired. Congenital webs commonly appear in the middle and inferior third of the esophagus, and they are more likely to be circumferential with a central or eccentric orifice. Acquired webs are much more common than congenital webs and typically appear in the cervical area (postcricoid). Clinical symptoms of this condition are selective (solid more than liquids) dysphagia, thoracic pain, nasopharyngeal reflux, aspiration, perforation and food impaction (the last two are very rare)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100595 ; owl:annotatedTarget "An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-a-Sialyllactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100596 ; owl:annotatedTarget "The nostrils (the paired channels of the nose) are not present." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100596 ; owl:annotatedTarget "Missing nostrils" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-alpha-Sialyllactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100598 ; owl:annotatedTarget "Fluid accumulation in the lungs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100598 ; owl:annotatedTarget "Excess fluid in lungs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100598 ; owl:annotatedTarget "Lung oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100598 ; owl:annotatedTarget "Wet lung" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100599 ; owl:annotatedTarget "Two penile structures, separated from the tip to the base of the shaft." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100599 ; owl:annotatedTarget "Penile duplication" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100600 ; owl:annotatedTarget "A partial or complete positional exchange between the penis and the scrotum, with positioning of the scrotum superior to the penis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100601 ; owl:annotatedTarget "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100602 ; owl:annotatedTarget "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100603 ; owl:annotatedTarget "Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "3'-sialyllactose" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100603 ; owl:annotatedTarget "Toxaemia of pregnancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100604 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100604 ; owl:annotatedTarget "Lip tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100604 ; owl:annotatedTarget "Lip tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100604 ; owl:annotatedTarget "Tumor of the lip" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100604 ; owl:annotatedTarget "Tumour of the lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100606 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the respiratory system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100606 ; owl:annotatedTarget "Respiratory system tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100606 ; owl:annotatedTarget "Respiratory system tumour" . [] oboInOwl:hasDbXref "PMID:15686299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100607 ; owl:annotatedTarget "Pain during menstruation that interferes with daily activities." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "32-N-Acetyl-a-neuraminyllactose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100607 ; owl:annotatedTarget "Painful menstruation" . [] oboInOwl:hasDbXref "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100608 ; owl:annotatedTarget "Bleeding at irregular intervals." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100608 ; owl:annotatedTarget "Abnormal uterus bleeding" . [] oboInOwl:hasDbXref , "PMID:28499529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100608 ; owl:annotatedTarget "Intermenstrual bleeding" . [] oboInOwl:hasDbXref , "PMID:28499529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100608 ; owl:annotatedTarget "Menstrual spotting" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100610 ; owl:annotatedTarget "A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100610 ; owl:annotatedTarget "High blood phenylalanine level in mother" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer", "PMID:20091054", "PMID:20367310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100611 ; owl:annotatedTarget "The presence of many cysts in the glomerulus of the kidney related to dilatation of the Bowman's capsule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100612 ; owl:annotatedTarget "Neoplasm involving odontogenic cells, an odontogenic tumor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100612 ; owl:annotatedTarget "Odontogenic tumour" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "32-N-Acetyl-alpha-neuraminyllactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100613 ; owl:annotatedTarget "Death between the age of 16 and 40 years." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100613 ; owl:annotatedTarget "Death in early adulthood" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "A2,3-Sialyllactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100614 ; owl:annotatedTarget "A general term for inflammation of the muscles without respect to the underlying cause." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100614 ; owl:annotatedTarget "Muscle inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100615 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the ovary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100615 ; owl:annotatedTarget "Ovarian cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100615 ; owl:annotatedTarget "Ovarian tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100615 ; owl:annotatedTarget "Ovarian tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100616 ; owl:annotatedTarget "The presence of a teratoma of the testis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "GM3 carbohydrate moiety" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100617 ; owl:annotatedTarget "The presence of a seminoma, an undifferentiated germ cell tumor of the testis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100618 ; owl:annotatedTarget "The presence of a neoplasm of the testis with origin in a Leydig cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100619 ; owl:annotatedTarget "The presence of a neoplasm of the testis with origin in a Sertoli cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100620 ; owl:annotatedTarget "A type of undifferentiated germ cell tumor that may be benign or malignant." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100621 ; owl:annotatedTarget "The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary." . [] oboInOwl:hasDbXref "PMID:25746572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100622 ; owl:annotatedTarget "A seizure during pregnancy." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100622 ; owl:annotatedTarget "Maternal seizures" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "N-Acetylneuraminoyllactose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:12139778" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "Neu5Aca2-3Galb1-4Glcb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100625 ; owl:annotatedTarget "Wide rib cage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100626 ; owl:annotatedTarget "Chronic liver failure" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "Neu5Acalpha2-3Galbeta1-4Glcbeta" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100627 ; owl:annotatedTarget "A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100628 ; owl:annotatedTarget "The presence of a diverticulum of the esophagus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100629 ; owl:annotatedTarget "A congenital malformation with a cleft (gap or opening) in the midline of the face." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100629 ; owl:annotatedTarget "Midline facial cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100630 ; owl:annotatedTarget "Tumor of the nasopharynx" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100630 ; owl:annotatedTarget "Tumour of the nasopharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100631 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the adrenal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100632 ; owl:annotatedTarget "The presence of a piece lung tissue which is not attached to the pulmonary blood supply and does not communicate with the other lung tissue (not connected to the standard bronchial airways and not performing a function in respiration)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100633 ; owl:annotatedTarget "Inflammation of the esophagus." . [] a owl:Axiom ; rdfs:label "Oesophagitis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100633 ; owl:annotatedTarget "MEDDRA:10030216" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3/a4-b1_b3-c2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100633 ; owl:annotatedTarget "Inflammation of the esophagus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100633 ; owl:annotatedTarget "Inflammation of the oesophagus" . [] oboInOwl:hasDbXref "NCIT:C3809", "PMID:28448665" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100634 ; owl:annotatedTarget "A tumor that originates from a neuroendocrine cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100635 ; owl:annotatedTarget "A paraganglioma (a neuroendocrine neoplasm) originating in a carotid artery." . [] oboInOwl:hasDbXref "PMID:26215714" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100636 ; owl:annotatedTarget "A rare paranglioma of the lung, tumors that arise from extra-adrenal chromaffin cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100638 ; owl:annotatedTarget "Tumor of the pharynx" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100638 ; owl:annotatedTarget "Tumour of the pharynx" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "a-Neu5Ac-(2->3)-b-D-Gal-(1->4)-D-Glc" . [] oboInOwl:hasDbXref "PMID:27188339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100639 ; owl:annotatedTarget "A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100639 ; owl:annotatedTarget "Abnormal erection" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100639 ; owl:annotatedTarget "Erectile abnormalities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose" . [] oboInOwl:hasDbXref , "PMID:24040590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100640 ; owl:annotatedTarget "Presence of a cyst (sac-like structure) located in the larynx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100641 ; owl:annotatedTarget "The presence of a neoplasm of the adrenal cortex." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Gal-(->4)-D-Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100642 ; owl:annotatedTarget "The presence of a neoplasm of the adrenal medulla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100643 ; owl:annotatedTarget "An anomaly of the color of the nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100643 ; owl:annotatedTarget "Abnormality of nail color" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100643 ; owl:annotatedTarget "Abnormality of nail colour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100644 ; owl:annotatedTarget "Brown or black discoloration of the nails." . [] a owl:Axiom ; rdfs:label "Melanonychia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100644 ; owl:annotatedTarget "MEDDRA:10058330" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100645 ; owl:annotatedTarget "Anterior vaginal wall prolapse with bulging of the bladder into the vagina." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100645 ; owl:annotatedTarget "Bladder hernia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100645 ; owl:annotatedTarget "Dropped bladder" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-delta-Gal-(1->4)-delta-Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100646 ; owl:annotatedTarget "Inflammation of the thyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100646 ; owl:annotatedTarget "Thyroid gland inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100647 ; owl:annotatedTarget "An autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis). This is caused by autoantibodies to the TSH-receptor (TSHR-Ab) that activate that TSH-receptor (TSHR), thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter). The resulting state of hyperthyroidism can cause a dramatic constellation of neuropsychological and physical signs and symptoms, which can severely compromise the patients." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59226 ; owl:annotatedTarget "alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100648 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the oral cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "Lesion of oral cavity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "Mouth tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "Mouth tumour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "Tumor of oral cavity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100649 ; owl:annotatedTarget "Tumour of oral cavity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100650 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the vagina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100650 ; owl:annotatedTarget "Vaginal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100650 ; owl:annotatedTarget "Vaginal tumour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "PMID:17113094" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100651 ; owl:annotatedTarget "A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100651 ; owl:annotatedTarget "Type 1 diabetes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100651 ; owl:annotatedTarget "Type I diabetes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100651 ; owl:annotatedTarget "Insulin-dependent diabetes mellitus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:15853927" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "PMID:9300789" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100653 ; owl:annotatedTarget "Inflammation of the optic nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100654 ; owl:annotatedTarget "Optic neuritis that occurs in the section of the optic nerve located behind the eyeball." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100657 ; owl:annotatedTarget "Congenital protrusion of the abdominal or thoracic viscera, usually with a defect of the sternum and ribs as well as of the abdominal walls." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100658 ; owl:annotatedTarget "Bacterial infection of skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100658 ; owl:annotatedTarget "Skin infection" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "acides gras cycliques" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "acidos grasos ciclicos" . [] oboInOwl:hasDbXref "PMID:30335330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100659 ; owl:annotatedTarget "An anomaly of the cerebral blood vessels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100659 ; owl:annotatedTarget "Abnormality of the cerebral blood vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100660 ; owl:annotatedTarget "A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100660 ; owl:annotatedTarget "Disorder of involuntary muscle movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100660 ; owl:annotatedTarget "Dyskinesias" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100661 ; owl:annotatedTarget "A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "cyclic fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100662 ; owl:annotatedTarget "Inflammation of cartilage." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100662 ; owl:annotatedTarget "Cartilage inflammation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59238 ; owl:annotatedTarget "zyklische Fettsaeuren" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100663 ; owl:annotatedTarget "A congenital malformation characterized by the union or approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100665 ; owl:annotatedTarget "Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100665 ; owl:annotatedTarget "Quincke oedema" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59252 ; owl:annotatedTarget "acyclic tetrapyrrole anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100668 ; owl:annotatedTarget "A developmental disorder in which there is a duplication the entire intestine or of a portion of the intestine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100668 ; owl:annotatedTarget "Bowel duplication" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100668 ; owl:annotatedTarget "Gut duplication" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59252 ; owl:annotatedTarget "acyclic tetrapyrrole anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100669 ; owl:annotatedTarget "An abnormality of the pigmentation of the mucosa of the mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100669 ; owl:annotatedTarget "Abnormal color of the oral mucosa" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100669 ; owl:annotatedTarget "Abnormal colour of the oral mucosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100669 ; owl:annotatedTarget "Abnormal pigmentation of oral mucous membrane" . [] oboInOwl:hasDbXref "PMID:409205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100670 ; owl:annotatedTarget "Coarse appearance of the components of the network of osseous tissue that makes up the cancellous structure of a bone, i.e., thickening of the (usually fine) white lines that are produced by trabeculae in radiograms." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59252 ; owl:annotatedTarget "linear tetrapyrrole anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100671 ; owl:annotatedTarget "Abnormal structure or form of trabecular bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100671 ; owl:annotatedTarget "Abnormal shape of spongy bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59266 ; owl:annotatedTarget "amino trisaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100672 ; owl:annotatedTarget "The presence of a hernia of the vagina." . [] oboInOwl:hasDbXref "PMID:32644551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100673 ; owl:annotatedTarget "A type of hydrocele testis in which the processus vaginalis remains patent only around the testes, and, as fluid accumulates, it renders the testes impalpable." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100677 ; owl:annotatedTarget "Varicosity of veins in the vulval region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100678 ; owl:annotatedTarget "The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms." . [] a owl:Axiom ; rdfs:label "Skin wrinkling" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100678 ; owl:annotatedTarget "MEDDRA:10040954" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100678 ; owl:annotatedTarget "Premature skin wrinkling" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100678 ; owl:annotatedTarget "Wrinkled skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100679 ; owl:annotatedTarget "Tight skin" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:15878720" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "CAS:11061-68-0" . [] oboInOwl:hasDbXref , "PMID:10464795" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100681 ; owl:annotatedTarget "A developmental disorder in which there is a duplication of a portion of the muscle and submucosa of the esophagus without epithelial duplication." . [] oboInOwl:hasDbXref , "PMID:9776081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100682 ; owl:annotatedTarget "A congenital absence or considerable underdevelopment of the trachea such that communication between the larynx proximally and the alveoli of the lungs distally is lacking." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100684 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of a salivary gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:22249812" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100684 ; owl:annotatedTarget "Tumor of salivary gland" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100684 ; owl:annotatedTarget "Tumour of salivary gland" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100684 ; owl:annotatedTarget "Cancer of salivary gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100685 ; owl:annotatedTarget "An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibres connecting periosteum to bone." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100685 ; owl:annotatedTarget "Abnormal Sharpey fibre morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100685 ; owl:annotatedTarget "Abnormality of Sharpey fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100686 ; owl:annotatedTarget "Inflammation of sharpey fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100687 ; owl:annotatedTarget "The presence of an extra auricle on one or both sides of the head." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:22617471" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100689 ; owl:annotatedTarget "A decreased anteroposterior thickness of the cornea." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100689 ; owl:annotatedTarget "Thin cornea" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:22715632" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100692 ; owl:annotatedTarget "An increase in the degree of curvature of the cornea compared to normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100693 ; owl:annotatedTarget "Tremulousness of the iris on movement of the eye, occurring in subluxation of the lens." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:22843207" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100694 ; owl:annotatedTarget "Twisted position of the tibia (shin bone) associated with pathological rotation of the leg." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100695 ; owl:annotatedTarget "Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise ." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100697 ; owl:annotatedTarget "A form of malignant cancer of the connective tissue surrounding nerves. Given its origin and behavior, it is classified as a sarcoma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100697 ; owl:annotatedTarget "Malignant peripheral nerve sheath tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100698 ; owl:annotatedTarget "A neurofibroma (benign peripheral nerve sheath tumor) localized in the subcutis (subcutaneous region)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:31301295" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100699 ; owl:annotatedTarget "Scarring" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100699 ; owl:annotatedTarget "Scar tissue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:31821343" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100700 ; owl:annotatedTarget "An abnormality of the Arachnoid mater." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:31876563" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100701 ; owl:annotatedTarget "An abnormality of the pia mater." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100702 ; owl:annotatedTarget "An extra-parenchymal and intra-arachnoidal collection of fluid with a composition similar to that of cerebrospinal fluid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100702 ; owl:annotatedTarget "Fluid-filled sac located in membrane surrounding brain or spinal cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100702 ; owl:annotatedTarget "Arachnoid cysts" . [] oboInOwl:hasDbXref "PMID:34413610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100703 ; owl:annotatedTarget "Pressing forward of the tongue in the mouth, a retained motoric habit from infantile swallowing patterns" . [] oboInOwl:hasDbXref , "PMID:28082927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100704 ; owl:annotatedTarget "A form of loss of vision caused by damage to the visual cortex rather than a defect in the eye." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100704 ; owl:annotatedTarget "CVI" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:32208558" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100705 ; owl:annotatedTarget "An abnormality of the glia cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:32398693" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100706 ; owl:annotatedTarget "One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:15941308" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:32629793" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100707 ; owl:annotatedTarget "An abnormality of astrocytes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:32797824" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100708 ; owl:annotatedTarget "An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "PMID:8019699" . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100710 ; owl:annotatedTarget "Acting on the spur of the moment in response to immediate stimuli; acting on a momentary basis without a plan or consideration of outcomes; difficulty establishing or following plans; a sense of urgency and self-harming behavior under emotional distress." . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100710 ; owl:annotatedTarget "Impulsive" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100710 ; owl:annotatedTarget "Impulsivity" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "Exubera" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100711 ; owl:annotatedTarget "An abnormality of the thoracic vertebral column." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "Insulin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100712 ; owl:annotatedTarget "Any structural abnormality of the lumbar vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100716 ; owl:annotatedTarget "Aggression towards oneself." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100716 ; owl:annotatedTarget "Self-injurious behavior" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100716 ; owl:annotatedTarget "Self-injurious behaviour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100716 ; owl:annotatedTarget "Self-injurious behaviors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100716 ; owl:annotatedTarget "Self-injurious behaviours" . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "Insulin recombinant" . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100717 ; owl:annotatedTarget "Any structural anomaly of the cementum, which is the mineralized connective tissue covering the dental root. The cementum allows anchoring of the fibers of the periodontal ligament. Cementum is secreted by cementoblasts, which may be, later on, embedded in the cementum. Cementum can be acellular (along the two third coronal portion of the root) and cellular (in the apical and interradicular part of the root)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "human insulin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100719 ; owl:annotatedTarget "A sectoral indentation of the crystalline lens, usually due to zonular weakness or absence." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100720 ; owl:annotatedTarget "Underdeveloped ear cartilage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100721 ; owl:annotatedTarget "Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100721 ; owl:annotatedTarget "Swollen lymph nodes in center of chest" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100721 ; owl:annotatedTarget "Swollen lymph nodes in centre of chest" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "GI stroma tumor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "insulin (recombinant)" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "GI stroma tumour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "GIST" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "Gastrointestinal stroma tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "Gastrointestinal stromal tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "Gastrointestinal stromal tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100723 ; owl:annotatedTarget "Gastrointestinal stromal tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100724 ; owl:annotatedTarget "An abnormality of coagulation associated with an increased risk of thrombosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100725 ; owl:annotatedTarget "Thickening and hardening of the epidermis seen with exaggeration of normal skin lines." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100726 ; owl:annotatedTarget "A systemic disease which can present with cutaneous lesions with or without internal involvement. Tumors are caused by Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100727 ; owl:annotatedTarget "An excessive number of histiocytes (tissue macrophages)." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "insulin human" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100729 ; owl:annotatedTarget "Big face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100729 ; owl:annotatedTarget "Large face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100729 ; owl:annotatedTarget "Large facies" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "insulina humana" . [] oboInOwl:hasDbXref , "PMID:24605255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100730 ; owl:annotatedTarget "A rare congenital cystic lesion of the lungs in the mediastinum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jhurst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100731 ; owl:annotatedTarget "A horizontal cleft of the face, varying from slight widening of the mouth, to a cleft extending to the ear." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100733 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the parathyroid gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:16162015" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "insuline humaine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100734 ; owl:annotatedTarget "Abnormal shape of the end part of the vertebra bone" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5931 ; owl:annotatedTarget "insulinum humanum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100736 ; owl:annotatedTarget "An abnormality of the soft palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100736 ; owl:annotatedTarget "Abnormality of the muscular palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100736 ; owl:annotatedTarget "Abnormality of the velum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100736 ; owl:annotatedTarget "Abnormality of the velum palatinum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100737 ; owl:annotatedTarget "Abnormality of the secondary palate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59326 ; owl:annotatedTarget "prostaglandin carboxylic acid anions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100738 ; owl:annotatedTarget "Abnormal eating behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100738 ; owl:annotatedTarget "Abnormal eating behaviour" . [] oboInOwl:hasDbXref , "PMID:23346610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100739 ; owl:annotatedTarget "A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100739 ; owl:annotatedTarget "Binge and purge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100742 ; owl:annotatedTarget "A benign or malignant neoplasm (tumor) originating in the vascular system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100742 ; owl:annotatedTarget "Blood vessel tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100742 ; owl:annotatedTarget "Blood vessel tumour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100743 ; owl:annotatedTarget "Rectal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100743 ; owl:annotatedTarget "Rectal tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59554 ; owl:annotatedTarget "MCFA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100745 ; owl:annotatedTarget "An anomaly of the joint between the trochlear notch of ulna and the trochlea of humerus, which is part of the elbow joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100746 ; owl:annotatedTarget "A type of Macrodactyly affecting one or several fingers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100747 ; owl:annotatedTarget "A type of Macrodactyly affecting one or several toes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59554 ; owl:annotatedTarget "MCFAs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100748 ; owl:annotatedTarget "Muscular oedema" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100749 ; owl:annotatedTarget "Chest pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100750 ; owl:annotatedTarget "Collapse of part of a lung associated with absence of inflation (air) of that part." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100750 ; owl:annotatedTarget "Partial or complete collapse of part or entire lung" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100751 ; owl:annotatedTarget "Esophageal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100751 ; owl:annotatedTarget "Esophageal tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59554 ; owl:annotatedTarget "medium-chain fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100752 ; owl:annotatedTarget "Formation of abnormal lobules (small masses of tissue) in the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100753 ; owl:annotatedTarget "A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%." . [] oboInOwl:hasDbXref "PMID:15104084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100754 ; owl:annotatedTarget "A state of abnormally elevated or irritable mood, arousal, and or energy levels." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100754 ; owl:annotatedTarget "Manic" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100755 ; owl:annotatedTarget "Abnormal spit" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100755 ; owl:annotatedTarget "Abnormality of salivation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100757 ; owl:annotatedTarget "A rare pediatric carcinoma of the pancreas." . [] oboInOwl:hasDbXref "ISBN:9780781770873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100758 ; owl:annotatedTarget "A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100758 ; owl:annotatedTarget "Death of body tissue due to lack of blood flow or infection" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "Terminal broadening of the fingers (distal phalanges of the fingers)." . [] a owl:Axiom ; rdfs:label "Finger clubbing" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "MEDDRA:10016680" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "Clubbed fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "Clubbing (hands)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "MCFA anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "Clubbing of fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100759 ; owl:annotatedTarget "Finger clubbing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100760 ; owl:annotatedTarget "Terminal broadening of the toes (distal phalanges of the toes)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100760 ; owl:annotatedTarget "Clubbed toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100762 ; owl:annotatedTarget "Bleeding into the biliary tree." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:16181134" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "MCFA anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100763 ; owl:annotatedTarget "An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively." . [] oboInOwl:hasDbXref , "PMID:12376602" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100764 ; owl:annotatedTarget "Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "a medium chain fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100765 ; owl:annotatedTarget "An abnormality of the tonsils." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Lymphatic_vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100766 ; owl:annotatedTarget "A structural anomaly of the vessel that contains or conveys lymph fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "medium-chain FA anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100767 ; owl:annotatedTarget "An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100767 ; owl:annotatedTarget "Placental issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100768 ; owl:annotatedTarget "A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "medium-chain FA anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59558 ; owl:annotatedTarget "medium-chain fatty acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100770 ; owl:annotatedTarget "Excessively active peristalsis (wave of contraction of the tubular organs of the gastrointestinal tract) marked by excessive rapidity of the passage of food through the stomach and intestine." . [] oboInOwl:hasDbXref , "http://www.healthhype.com/stomach-churning-sensation-feeling-causes-remedies.html" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100770 ; owl:annotatedTarget "Stomach churning" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100771 ; owl:annotatedTarget "Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100771 ; owl:annotatedTarget "Intestinal hypoperistalsis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100773 ; owl:annotatedTarget "Cartilage destruction" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59561 ; owl:annotatedTarget "diamino acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100774 ; owl:annotatedTarget "Excessive growth or abnormal thickening of bone tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100774 ; owl:annotatedTarget "Bone overgrowth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100775 ; owl:annotatedTarget "A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100776 ; owl:annotatedTarget "An increased susceptibility to pharyngitis as manifested by a history of recurrent pharyngitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100776 ; owl:annotatedTarget "Recurrent sore throat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100777 ; owl:annotatedTarget "An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100777 ; owl:annotatedTarget "Formation of new noncancerous bone on top of existing bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100778 ; owl:annotatedTarget "Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100779 ; owl:annotatedTarget "A rare birth defect in women where the urethra and vagina both open into a common channel." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59644 ; owl:annotatedTarget "PMID:6434570" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100780 ; owl:annotatedTarget "A hamartoma (disordered proliferation of mature tissues) of the conjunctiva." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59644 ; owl:annotatedTarget "PMID:8454196" . [] oboInOwl:hasDbXref , "PMID:16700283" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100781 ; owl:annotatedTarget "An anomaly of the sacroiliac joint, which connects the base of the spine (sacrum) to the ilium (a hip bone)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:16287364" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59644 ; owl:annotatedTarget "PMID:8638935" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100783 ; owl:annotatedTarget "Absent breast" . [] oboInOwl:hasDbXref "PMID:23423416" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100785 ; owl:annotatedTarget "Persistent difficulty initiating or maintaining sleep." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100785 ; owl:annotatedTarget "Difficulty staying or falling asleep" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100785 ; owl:annotatedTarget "Fragmented sleep" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100786 ; owl:annotatedTarget "Excessive sleepiness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59644 ; owl:annotatedTarget "oxo fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100788 ; owl:annotatedTarget "Lack of separation of the upper and lower lips." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100788 ; owl:annotatedTarget "Adhesion of upper and lower lips" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100788 ; owl:annotatedTarget "Fused lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100788 ; owl:annotatedTarget "Fusion of upper and lower lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100789 ; owl:annotatedTarget "A bony protrusion present on the midline of the hard palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100789 ; owl:annotatedTarget "Maxillary torus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59740 ; owl:annotatedTarget "nucleophile" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100789 ; owl:annotatedTarget "Palatal tori" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100789 ; owl:annotatedTarget "Palatal torus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100789 ; owl:annotatedTarget "Prominent midpalatal ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100790 ; owl:annotatedTarget "Hernias" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100792 ; owl:annotatedTarget "The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59740 ; owl:annotatedTarget "nucleophiles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100795 ; owl:annotatedTarget "The absence of the normal curvature of the vertebral column." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100795 ; owl:annotatedTarget "Abnormally straight spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100796 ; owl:annotatedTarget "Testicular inflammation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100796 ; owl:annotatedTarget "Inflammation of testicles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59740 ; owl:annotatedTarget "nucleophilic reagents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100797 ; owl:annotatedTarget "An abnormality of the development of the toenails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100797 ; owl:annotatedTarget "Abnormal toenail development" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100798 ; owl:annotatedTarget "An abnormality of the development of the fingernails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100798 ; owl:annotatedTarget "Abnormal fingernail development" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100799 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the middle ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100799 ; owl:annotatedTarget "Middle ear tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100799 ; owl:annotatedTarget "Middle ear tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100800 ; owl:annotatedTarget "A congenital underdevelopment (aplasia or hypoplasia) of the pancreas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100800 ; owl:annotatedTarget "Absent/small pancreas" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100800 ; owl:annotatedTarget "Absent/underdeveloped pancreas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59814 ; owl:annotatedTarget "L-alpha-amino carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100801 ; owl:annotatedTarget "Aplasia of the pancreas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100801 ; owl:annotatedTarget "Absent pancreas" . [] oboInOwl:hasDbXref , "PMID:16465538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100802 ; owl:annotatedTarget "Abnormal anatomical location of the stomach. This feature may be due to intestinal malrotation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59826 ; owl:annotatedTarget "progestins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100802 ; owl:annotatedTarget "Abnormal stomach location" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100803 ; owl:annotatedTarget "An abnormality of the region around the nails of the fingers or toes." . [] oboInOwl:hasDbXref , "PMID:18815399" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100804 ; owl:annotatedTarget "Flesh-colored papule in or around the nail bed. Ungual fibromas may be periungual (arising under the proximal nail fold) or subungual (originating under the nail plate)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100804 ; owl:annotatedTarget "Koenen tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100804 ; owl:annotatedTarget "Koenen's tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100806 ; owl:annotatedTarget "Systemic inflammatory response to infection." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100806 ; owl:annotatedTarget "Infection in blood stream" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100807 ; owl:annotatedTarget "The middle finger is more than 2 SD above the mean for newborns 27 to 41 weeks EGA or above the 97th centile for children from birth to 16 years of age AND the five digits retain their normal length proportions relative to each other (i.e., it is not the case that the middle finger is the only lengthened digit), or, Fingers that appear disproportionately long compared to the palm of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100807 ; owl:annotatedTarget "Long fingers" . [] oboInOwl:hasDbXref , "PMID:22257431" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100808 ; owl:annotatedTarget "An outpouching of the gastric wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100809 ; owl:annotatedTarget "Pain or discomfort of the scalp elicited by palpation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100809 ; owl:annotatedTarget "Scalp pain" . [] a owl:Axiom ; rdfs:label "Scalp tenderness" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100809 ; owl:annotatedTarget "MEDDRA:10039521" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59835 ; owl:annotatedTarget "OH-FA anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100809 ; owl:annotatedTarget "Scalp tenderness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100809 ; owl:annotatedTarget "Allodynia of scalp" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100810 ; owl:annotatedTarget "Pointed ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100810 ; owl:annotatedTarget "Spock's ear" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:16406688" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59835 ; owl:annotatedTarget "OH-FA-anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100811 ; owl:annotatedTarget "Congenital absence or underdevelopment of the colon." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100811 ; owl:annotatedTarget "Absent/small colon" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100811 ; owl:annotatedTarget "Absent/underdeveloped colon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100812 ; owl:annotatedTarget "Noticeably unpleasant odors exhaled in breathing." . [] a owl:Axiom ; rdfs:label "Breath odour" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100812 ; owl:annotatedTarget "MEDDRA:10006326" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100812 ; owl:annotatedTarget "Bad breath" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100813 ; owl:annotatedTarget "Testicular torsion is when the spermatic cord to a testicle twists, cutting off the blood supply. The most common symptom is acute testicular pain." . [] oboInOwl:hasSynonymType hp:layperson, hp:obsolete_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100814 ; owl:annotatedTarget "Mongolian spot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59835 ; owl:annotatedTarget "OH-fatty acid anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59835 ; owl:annotatedTarget "OH-fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100816 ; owl:annotatedTarget "Darkening of skin of the lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100816 ; owl:annotatedTarget "Hyperpigmentation of lip vermillion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100816 ; owl:annotatedTarget "Increased pigmentation on the lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100817 ; owl:annotatedTarget "The presence of hypertension related to stenosis of the renal artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100818 ; owl:annotatedTarget "Increased inferior to superior extent of the thorax." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100818 ; owl:annotatedTarget "Long rib cage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59835 ; owl:annotatedTarget "hydroxy fatty acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100819 ; owl:annotatedTarget "An abnormal connection between the gut and another hollow organ, such as the bladder, urethra, vagina, or other regions of the gastrointestinal tract." . [] a owl:Axiom ; rdfs:label "Intestinal fistula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100819 ; owl:annotatedTarget "MEDDRA:10022647" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100820 ; owl:annotatedTarget "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100820 ; owl:annotatedTarget "Diseased glomeruli" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100821 ; owl:annotatedTarget "The prolapse of the female urethra into the vagina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100822 ; owl:annotatedTarget "A Rectocele results from a tear in the rectovaginal septum (which is normally a tough, fibrous, sheet-like divider between the rectum and vagina). Rectal tissue bulges through this tear and into the vagina as a hernia. There are two main causes of this tear: childbirth, and hysterectomy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100825 ; owl:annotatedTarget "Inflammation of the lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100825 ; owl:annotatedTarget "Inflammation of the lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100825 ; owl:annotatedTarget "Red and sore lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100826 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the nail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100826 ; owl:annotatedTarget "Nail tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100826 ; owl:annotatedTarget "Nail tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59836 ; owl:annotatedTarget "oxo fatty acid anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59836 ; owl:annotatedTarget "oxo-FA anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100827 ; owl:annotatedTarget "Increase in the number or proportion of lymphocytes in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100827 ; owl:annotatedTarget "High lymphocyte count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100829 ; owl:annotatedTarget "Spontaneous flow of milk from the breast, unassociated with childbirth or nursing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59836 ; owl:annotatedTarget "oxo-FA anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100829 ; owl:annotatedTarget "Spontaneous milk flow from breast" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100830 ; owl:annotatedTarget "Round ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100831 ; owl:annotatedTarget "Vitamin K is a fat-soluble vitamin with a role in promoting the coagulation cascade." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100831 ; owl:annotatedTarget "Abnormality of vitamin K metabolism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100832 ; owl:annotatedTarget "Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100832 ; owl:annotatedTarget "Eye floaters" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100832 ; owl:annotatedTarget "Spots in front of eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100833 ; owl:annotatedTarget "The presence of a neoplasm of the small intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100833 ; owl:annotatedTarget "Small intestine tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100833 ; owl:annotatedTarget "Small intestine tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100834 ; owl:annotatedTarget "The presence of a neoplasm of the large intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100834 ; owl:annotatedTarget "Large intestine tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100834 ; owl:annotatedTarget "Large intestine tumour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "PMID:1226425" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100835 ; owl:annotatedTarget "Benign neoplasm of the CNS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100836 ; owl:annotatedTarget "A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100836 ; owl:annotatedTarget "Malignant neoplasm of the CNS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100837 ; owl:annotatedTarget "Symmetrical vermiform facial atrophy that affects mainly the forehead, the chin, the ear lobes and helices. Atrophodermia vermiculata is characterized by erythema and follicular plugs on the cheeks, developing into painless reticular impressions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100838 ; owl:annotatedTarget "An increased susceptibility to cutaneous abscess formation, as manifested by a medical history of recurrent cutaneous abscesses." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:16804013" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "PMID:17392575" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100839 ; owl:annotatedTarget "Absence of the liver owing to a failure of the liver to develop." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100839 ; owl:annotatedTarget "Failed liver development" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "PMID:3094448" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Absence or underdevelopment of the eyebrow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Absence of eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Agenesis of eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Hypotrophic eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Lack of eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Missing eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Sparse or absent eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Sparse to absent eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100840 ; owl:annotatedTarget "Sparse/absent eyebrows" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "PMID:7406063" . [] oboInOwl:hasDbXref "PMID:10067744" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100841 ; owl:annotatedTarget "A developmental anomaly wtih a small tubular or saccular midline stomach." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100842 ; owl:annotatedTarget "Underdevelopment of the optic nerve and absence of the septum pellucidum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100845 ; owl:annotatedTarget "An acute hypersensitivity reaction due to exposure to a previously encountered antigen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100845 ; owl:annotatedTarget "Anaphylaxis" . [] oboInOwl:hasDbXref , "PMID:23209116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100847 ; owl:annotatedTarget "A chronic, relapsing, pustular eruption that is localized to the palms and soles." . [] a owl:Axiom ; rdfs:label "Palmoplantar pustulosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100847 ; owl:annotatedTarget "MEDDRA:10050185" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100848 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the male external genitalia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100849 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the scrotum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100849 ; owl:annotatedTarget "Scrotum tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100849 ; owl:annotatedTarget "Scrotum tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "3-OH fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100850 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the penis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100850 ; owl:annotatedTarget "Penis tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100850 ; owl:annotatedTarget "Penis tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "3-OH fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100851 ; owl:annotatedTarget "An abnormality of emotional behaviour." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100852 ; owl:annotatedTarget "An abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100852 ; owl:annotatedTarget "Abnormal fear/anxiety-related behaviour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "3-hydroxy fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100853 ; owl:annotatedTarget "Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "beta-OH fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100854 ; owl:annotatedTarget "Absence of the musculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100854 ; owl:annotatedTarget "Absent musculature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "beta-OH fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100855 ; owl:annotatedTarget "Hypoplasia of the triceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100855 ; owl:annotatedTarget "Small triceps" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100855 ; owl:annotatedTarget "Underdeveloped triceps" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "beta-hydroxy fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100856 ; owl:annotatedTarget "Decreased ossification of the vertebral bodies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59845 ; owl:annotatedTarget "beta-hydroxy fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100857 ; owl:annotatedTarget "An abnormally flat sella turcica." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:17031479" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100858 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the wall of the celiac artery." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100858 ; owl:annotatedTarget "Dilatation of coeliac artery" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0100858 ; owl:annotatedTarget "Coeliac artery aneurysm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59869 ; owl:annotatedTarget "L-alpha-amino acid zwitterions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100859 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the wall of the superior mesenteric artery ." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59869 ; owl:annotatedTarget "an L-alpha-amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100860 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery ." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100861 ; owl:annotatedTarget "Increase in bone density of the vertebral body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59871 ; owl:annotatedTarget "D-alpha-amino acid zwitterions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100862 ; owl:annotatedTarget "Absent femoral head" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59871 ; owl:annotatedTarget "a D-alpha-amino acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100863 ; owl:annotatedTarget "Absent neck of thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100864 ; owl:annotatedTarget "An abnormally short femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100864 ; owl:annotatedTarget "Short neck of thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100865 ; owl:annotatedTarget "Increased width of the ischium, which forms the lower and back part of the hip bone." . [] oboInOwl:hasDbXref "PMID:29019756" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100866 ; owl:annotatedTarget "Underdevelopment of the iliac bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100866 ; owl:annotatedTarget "Short pelvis bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59874 ; owl:annotatedTarget "N-acyl-L-alpha-amino acid(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100867 ; owl:annotatedTarget "The narrowing or partial blockage of a portion of the duodenum." . [] a owl:Axiom ; rdfs:label "Duodenal stenosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0100867 ; owl:annotatedTarget "MEDDRA:10050094" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59874 ; owl:annotatedTarget "an N-acyl-L-amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100869 ; owl:annotatedTarget "The presence of telangiectases on the skin of palm of hand." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:1735411" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100870 ; owl:annotatedTarget "Telangiectases (small dilated blood vessels) located on the skin of sole of foot." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59876 ; owl:annotatedTarget "N-acyl-D-alpha-amino acid(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100871 ; owl:annotatedTarget "An abnormality of the palm, that is, of the front of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100871 ; owl:annotatedTarget "Abnormality of the palm" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59876 ; owl:annotatedTarget "an N-acyl-D-amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100872 ; owl:annotatedTarget "An abnormality of the plantar part of foot, that is of the soles of the feet." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100874 ; owl:annotatedTarget "Increased density of hairs, i.e., and elevated number of hairs per unit area." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100874 ; owl:annotatedTarget "Increased follicular density" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100874 ; owl:annotatedTarget "Increased hair density" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100874 ; owl:annotatedTarget "Thick hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Increased length and width of one half of the tounge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Hemiglossal hyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Hyperplasia of half of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Hemiglossal hypertrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Hypertrophy of half of the tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Increased size of half of the tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100875 ; owl:annotatedTarget "Large half of tongue" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100876 ; owl:annotatedTarget "Skin crease extending from below the inner canthus laterally along the malar process of the maxilla and zygoma." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100876 ; owl:annotatedTarget "Crease in skin under the eye" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59888 ; owl:annotatedTarget "Gmelin:1041559" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100876 ; owl:annotatedTarget "Groove in skin under the eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100877 ; owl:annotatedTarget "Cystic, urine-containing intrarenal cavities lined with transitional cell epithelium that communicate through a narrow channel with the collecting system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100878 ; owl:annotatedTarget "Enlarged uterus" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_59888 ; owl:annotatedTarget "4-azaniumylbutanoate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100879 ; owl:annotatedTarget "Enlarged ovaries" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100880 ; owl:annotatedTarget "Abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100881 ; owl:annotatedTarget "Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59888 ; owl:annotatedTarget "4-aminobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100882 ; owl:annotatedTarget "A rare, benign soft tissue tumor that typically occurs within the first two years of life." . [] oboInOwl:hasDbXref , "PMID:20594143", "PMID:24251055" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100883 ; owl:annotatedTarget "Hamartoma-like growth in the placenta consisting of blood vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100884 ; owl:annotatedTarget "A scoliosis which is the results of a difference in leg length (which might be due to hemihypertrophy or hemihypotrophy of a leg) and the resulting tilting of the pelvis. If untreated this will lead to the development of scoliosis over time." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100885 ; owl:annotatedTarget "Persistence of the embryonic dorsal or sciatic vein system that normally should have involuted around the tenth to twelfth week of intrauterine life." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59888 ; owl:annotatedTarget "4-ammoniobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100886 ; owl:annotatedTarget "An abnormality in the placement of the ocular globe (eyeball)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100886 ; owl:annotatedTarget "Abnormality of eyeball location" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100886 ; owl:annotatedTarget "Abnormality of eyeball position" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100886 ; owl:annotatedTarget "Abnormality of globe position" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100887 ; owl:annotatedTarget "An abnormality in the size of the ocular globe (eyeball)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100887 ; owl:annotatedTarget "Abnormality of eyeball size" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100887 ; owl:annotatedTarget "Eye size difference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100889 ; owl:annotatedTarget "An abnormality of the Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract, formed by the union of the Common hepatic duct and the Cystic duct from the gall bladder." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:17443912" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_59905 ; owl:annotatedTarget "Gmelin:328863" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100891 ; owl:annotatedTarget "A cleft of the xiphoid process of the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100892 ; owl:annotatedTarget "An abnormality of the xiphoid process of the sternum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_59905 ; owl:annotatedTarget "2-(3,4-dihydroxyphenyl)ethanaminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100893 ; owl:annotatedTarget "Increased prominence of the xiphoid process of the sternum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59905 ; owl:annotatedTarget "2-(3,4-dihydroxyphenyl)ethan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100894 ; owl:annotatedTarget "Increased side-to-side width of the xiphoid process of the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100896 ; owl:annotatedTarget "The presence of multiple rectal hyperplastic/adenomatous polyps." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100898 ; owl:annotatedTarget "Connective tissue nevi are hamartomas in which one or several components of the dermis is altered." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59905 ; owl:annotatedTarget "dopamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100899 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100899 ; owl:annotatedTarget "Increased bone density in the finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59905 ; owl:annotatedTarget "dopaminium cation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_59999 ; owl:annotatedTarget "Chemische Substanz" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100900 ; owl:annotatedTarget "Increased bone density in the outermost bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60004 ; owl:annotatedTarget "Mischung" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100901 ; owl:annotatedTarget "Increased bone density in the outermost bone of the middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100902 ; owl:annotatedTarget "Increased bone density in the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_60027 ; owl:annotatedTarget "Polymer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100903 ; owl:annotatedTarget "Increased bone density in the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100903 ; owl:annotatedTarget "Increased bone density in the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100903 ; owl:annotatedTarget "Increased bone density in the outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60027 ; owl:annotatedTarget "Kunststoff" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:18019400" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100904 ; owl:annotatedTarget "Increased bone density in the middle bone of the index finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_60039 ; owl:annotatedTarget "(2S)-pyrrolidinium-2-carboxylate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100905 ; owl:annotatedTarget "Increased bone density in the middle bone of the middle finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60039 ; owl:annotatedTarget "L-proline" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100906 ; owl:annotatedTarget "Increased bone density in the middle bone of the ring finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100907 ; owl:annotatedTarget "Increased bone density in the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100907 ; owl:annotatedTarget "Increased bone density in the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100907 ; owl:annotatedTarget "Increased bone density in the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60059 ; owl:annotatedTarget "dermatan" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60059 ; owl:annotatedTarget "dermatan polyanion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100908 ; owl:annotatedTarget "Increased bone density in the innermost bone of the index finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100909 ; owl:annotatedTarget "Increased bone density in innermost bone of the middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100910 ; owl:annotatedTarget "Increased bone density in the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60065 ; owl:annotatedTarget "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100911 ; owl:annotatedTarget "Increased bone density in innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100911 ; owl:annotatedTarget "Increased bone density in innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100911 ; owl:annotatedTarget "Increased bone density in innermost pinky finger bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60065 ; owl:annotatedTarget "ganglioside GM3 (d18:1(4E))" . [] a owl:Axiom ; rdfs:seeAlso ; owl:annotatedProperty obo:IAO_0000112 ; owl:annotatedSource obo:RO_0002220 ; owl:annotatedTarget "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:18076890" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100912 ; owl:annotatedTarget "An elevation of bone density in the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100912 ; owl:annotatedTarget "Increased bone density in the outermost bone of the thumb" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_60073 ; owl:annotatedTarget "5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100913 ; owl:annotatedTarget "An elevation of bone density in the proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100913 ; owl:annotatedTarget "Increased bone density in the innermost bone of the thumb" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60073 ; owl:annotatedTarget "N-acylneuraminate cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100914 ; owl:annotatedTarget "Increased bone density in 1st long bone of hand" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60073 ; owl:annotatedTarget "an N-acylneuraminate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100915 ; owl:annotatedTarget "An elevation in bone density in one or more distal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100915 ; owl:annotatedTarget "Increased bone density in outermost finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60164 ; owl:annotatedTarget "polyionic polymer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100916 ; owl:annotatedTarget "An elevation in bone density in one or more middle phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100916 ; owl:annotatedTarget "Increased bone density in middle finger bone of hand" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60242 ; owl:annotatedTarget "a monovalent cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100917 ; owl:annotatedTarget "An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100917 ; owl:annotatedTarget "Increased bone density in innermost finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100918 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the second finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100918 ; owl:annotatedTarget "Increased bone density in 2nd finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propionate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100919 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the third finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100919 ; owl:annotatedTarget "Increased bone density in middle finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:18773880" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "3,3',5-triiodo-L-thyronine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100920 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the fourth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100920 ; owl:annotatedTarget "Increased bone density in ring finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "3,3',5-triiodo-L-thyronine(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100921 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the fifth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100921 ; owl:annotatedTarget "Increased bone density in little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100921 ; owl:annotatedTarget "Increased bone density in pinkie finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "liothyronine anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100921 ; owl:annotatedTarget "Increased bone density in pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60308 ; owl:annotatedTarget "liothyronine(1-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100922 ; owl:annotatedTarget "Increased bone density in thumb bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60311 ; owl:annotatedTarget "thyroid hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100923 ; owl:annotatedTarget "An increase in bone density within the clavicle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100923 ; owl:annotatedTarget "Increased bone density in collarbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100923 ; owl:annotatedTarget "Osteosclerosis of the clavicles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100924 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100924 ; owl:annotatedTarget "Increased bone density in the toe bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60466 ; owl:annotatedTarget "a peptide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60466 ; owl:annotatedTarget "peptide zwitterions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100925 ; owl:annotatedTarget "An elevation in bone density in one or more foot bones. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100925 ; owl:annotatedTarget "Increased bone density in foot bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100926 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100926 ; owl:annotatedTarget "Increased bone density in 2nd toe bone" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60525 ; owl:annotatedTarget "PDB:3HBG" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100927 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100927 ; owl:annotatedTarget "Increased bone density in 3rd toe bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:19309105" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60525 ; owl:annotatedTarget "PDB:3HBP" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60525 ; owl:annotatedTarget "PDB:3HBQ" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100928 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the fourth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100928 ; owl:annotatedTarget "Increased bone density in 4th toe bone" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60525 ; owl:annotatedTarget "PMID:20356030" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100929 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the fifth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100929 ; owl:annotatedTarget "Increased bone density in little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100929 ; owl:annotatedTarget "Increased bone density in pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100929 ; owl:annotatedTarget "Increased bone density in pinky toe bone" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60525 ; owl:annotatedTarget "MoCo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100930 ; owl:annotatedTarget "An elevation in bone density in one or more phalanges of the big toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100930 ; owl:annotatedTarget "Increased bone density in big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100931 ; owl:annotatedTarget "An elevation in bone density in the proximal phalanx of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100931 ; owl:annotatedTarget "Increased bone density in the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100932 ; owl:annotatedTarget "An elevation in bone density in the proximal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100932 ; owl:annotatedTarget "Increased bone density in the innermost bone of the 3rd toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_606564 ; owl:annotatedTarget "Beilstein:8364130" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100933 ; owl:annotatedTarget "Increased bone density in the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_606564 ; owl:annotatedTarget "(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100934 ; owl:annotatedTarget "Increased bone density in the innermost bone of the little toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606564 ; owl:annotatedTarget "prostaglandin E2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100934 ; owl:annotatedTarget "Increased bone density in the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100934 ; owl:annotatedTarget "Increased bone density in the innermost bone of the pinky toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:20017611" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606564 ; owl:annotatedTarget "prostaglandin E2 anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100935 ; owl:annotatedTarget "Increased bone density in the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100936 ; owl:annotatedTarget "An elevation in bone density in the middle phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100936 ; owl:annotatedTarget "Increased bone density in the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100937 ; owl:annotatedTarget "Increased bone density in the middle bone of the 4th toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "Beilstein:3610359" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "Gmelin:329632" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100938 ; owl:annotatedTarget "Increased bone density in the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100938 ; owl:annotatedTarget "Increased bone density in the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100938 ; owl:annotatedTarget "Increased bone density in the middle bone of the pinky toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "PMID:22153801" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100939 ; owl:annotatedTarget "Increased bone density in the outermost bone of the 2nd toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "Reaxys:3610359" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100940 ; owl:annotatedTarget "An elevation in bone density in the distal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100940 ; owl:annotatedTarget "Increased bone density in the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "(benzoylamino)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100941 ; owl:annotatedTarget "Increased bone density in the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "2-benzamidoacetate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "N-benzoylglycinate anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100942 ; owl:annotatedTarget "Increased bone density in the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100942 ; owl:annotatedTarget "Increased bone density in the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100942 ; owl:annotatedTarget "Increased bone density in the outermost bone of the pinky toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:20681748" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "N-benzoylglycinate(1-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100943 ; owl:annotatedTarget "Increased bone density in the innermost bone of the big toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "N-benzoylglycine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100944 ; owl:annotatedTarget "Increased bone density in the outermost bone of the big toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_606565 ; owl:annotatedTarget "hippurate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100945 ; owl:annotatedTarget "Increased bone density in the 1st long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60895 ; owl:annotatedTarget "D-alpha-amino acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100946 ; owl:annotatedTarget "An elevation in bone density in one or more proximal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100946 ; owl:annotatedTarget "Increased bone density in innermost toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60895 ; owl:annotatedTarget "D-alpha-amino carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100947 ; owl:annotatedTarget "An elevation in bone density in one or more middle phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100947 ; owl:annotatedTarget "Increased bone density in middle toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60911 ; owl:annotatedTarget "melange racemique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100948 ; owl:annotatedTarget "An elevation in bone density in one or more distal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100948 ; owl:annotatedTarget "Increased bone density in the outermost bone of the toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60911 ; owl:annotatedTarget "racemates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60911 ; owl:annotatedTarget "racemic mixture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100952 ; owl:annotatedTarget "An increase in size of the subarachnoid space associated with the lateral cerebral sulcus (Sylvian fissure)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100954 ; owl:annotatedTarget "Underdevelopment of the operculum." . [] oboInOwl:hasDbXref , "PMID:22343825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100957 ; owl:annotatedTarget "Any structural abnormality of the medulla of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100958 ; owl:annotatedTarget "Decreased width of the foramen obturatorium. The foramen obturatorium (also known as the obturator foramen) is a hole located between the ischium and pubis bones of the pelvis." . [] oboInOwl:hasDbXref , "PMID:10352605" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100959 ; owl:annotatedTarget "Dense radiopaque bands of bone which are thicker than the adjacent diaphyseal cortex and may form at the metaphysis of growing bones. They appear on radiographs as bone that is more radiopaque that the adjacent diaphyseal cortex." . [] oboInOwl:hasDbXref , "PMID:18253688", "PMID:2257506" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100960 ; owl:annotatedTarget "Abnormal difference in size between the left and right lateral cerebral ventricles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:24398899" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60924 ; owl:annotatedTarget "keratan sulfates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100961 ; owl:annotatedTarget "Increase in size of the hippocampus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100962 ; owl:annotatedTarget "Shyness" . [] oboInOwl:hasDbXref "PMID:33085272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100963 ; owl:annotatedTarget "Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain." . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60924 ; owl:annotatedTarget "keratosulfate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200000 ; owl:annotatedTarget "Different levels of maturation of different bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200001 ; owl:annotatedTarget "A type of dysharmonic skeletal maturation in which there is an acceleration in skeletal maturation whose degree differs markedly in different bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200003 ; owl:annotatedTarget "Flaring (widening) of the epiphysis." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "CAS:80446-87-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200003 ; owl:annotatedTarget "Splayed end part of bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200005 ; owl:annotatedTarget "The presence of an abnormal shape of the palpebral fissure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200005 ; owl:annotatedTarget "Abnormal morphology of the palpebral fissure" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:12020649" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200005 ; owl:annotatedTarget "Abnormal shape of the opening between the eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200006 ; owl:annotatedTarget "Slanting of the opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200007 ; owl:annotatedTarget "An abnormal size of the palpebral fissures for example unusually long or short palpebral fissures." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:16133831" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200007 ; owl:annotatedTarget "Abnormal size of the opening between the eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200007 ; owl:annotatedTarget "Abnormal size of the eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200008 ; owl:annotatedTarget "The presence of multiple polyps in the intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0200008 ; owl:annotatedTarget "Growths in inner lining of intestine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200008 ; owl:annotatedTarget "Gastrointestinal polyps" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:17991151" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200013 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of adipose tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:2292729" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200013 ; owl:annotatedTarget "Tumor of fatty tissue" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200013 ; owl:annotatedTarget "Tumour of fatty tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200016 ; owl:annotatedTarget "Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:2456994" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200017 ; owl:annotatedTarget "Congenital defect with failure of the development of the cerebral white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200018 ; owl:annotatedTarget "A type of anomalous trichromacy associated with defective long-wavelength-sensitive (L) cones, causing the sensitivity spectrum to be shifted toward medium wavelengths. This leads to difficulties especially in distinguishing red and green." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200018 ; owl:annotatedTarget "Red-weak" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200020 ; owl:annotatedTarget "An erosion or abrasion of the cornea's outermost layer of epithelial cells." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200020 ; owl:annotatedTarget "Damage to outer layer of the cornea of the eye" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "PMID:9538266" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200021 ; owl:annotatedTarget "Low set, steeply sloping shoulders." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200021 ; owl:annotatedTarget "Down-sloping shoulders" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200021 ; owl:annotatedTarget "Rounded shoulders" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200021 ; owl:annotatedTarget "Rounded, sloping shoulders" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200021 ; owl:annotatedTarget "Sloping shoulders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200022 ; owl:annotatedTarget "Choroid plexus papilloma is a histologically benign neoplasm located in the ventricular system of the choroid plexus." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Reaxys:5386141" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200023 ; owl:annotatedTarget "A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:2674258" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-D-glucopyranose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200024 ; owl:annotatedTarget "The presence of premature sister chromatid segregation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200025 ; owl:annotatedTarget "Lower jaw pain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200026 ; owl:annotatedTarget "Eye pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200028 ; owl:annotatedTarget "A diffuse, non-pitting edema and thickening of the skin usually on the anterior aspect of the lower legs spreading to the dorsum of the feet." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200028 ; owl:annotatedTarget "Graves dermopathy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200029 ; owl:annotatedTarget "Cutaneous vasculitis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200032 ; owl:annotatedTarget "Grey-green or brownish-pigmented ring in the deep epithelial layers at the outer border of the cornea." . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "(Gal)2 (Glc)1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200032 ; owl:annotatedTarget "Fleischer's ring" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200032 ; owl:annotatedTarget "Fleischer-Kayser ring" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200032 ; owl:annotatedTarget "Fleischer-Struempell ring" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200034 ; owl:annotatedTarget "A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point." . [] a owl:Axiom ; rdfs:label "Papule" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0200034 ; owl:annotatedTarget "MEDDRA:10033733" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200034 ; owl:annotatedTarget "Papules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200035 ; owl:annotatedTarget "A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200036 ; owl:annotatedTarget "Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200037 ; owl:annotatedTarget "A circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200039 ; owl:annotatedTarget "A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "4'-galactosyllactose" . [] a owl:Axiom ; rdfs:label "Pustule" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0200039 ; owl:annotatedTarget "MEDDRA:10037578" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200039 ; owl:annotatedTarget "Pimple" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200039 ; owl:annotatedTarget "Pustules" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200039 ; owl:annotatedTarget "Skin pustules" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "4-O-(4-O-alpha-D-galactopyranosyl-beta-D-galactopyranosyl)-D-glucopyranose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200040 ; owl:annotatedTarget "Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200040 ; owl:annotatedTarget "Skin cyst" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200040 ; owl:annotatedTarget "Epidermoid cysts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200041 ; owl:annotatedTarget "A discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed." . [] a owl:Axiom ; rdfs:label "Skin erosion" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0200041 ; owl:annotatedTarget "MEDDRA:10040840" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Gal-alpha-1,4-Gal-beta-1,4-Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200042 ; owl:annotatedTarget "A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat." . [] a owl:Axiom ; rdfs:label "Skin ulcer" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0200042 ; owl:annotatedTarget "MEDDRA:10040943" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200042 ; owl:annotatedTarget "Open skin sore" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200043 ; owl:annotatedTarget "Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200043 ; owl:annotatedTarget "Warts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200044 ; owl:annotatedTarget "A clonal disorder of keratinization with one or multiple atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200046 ; owl:annotatedTarget "The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200046 ; owl:annotatedTarget "Cat cry" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200046 ; owl:annotatedTarget "cat-like cry" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200046 ; owl:annotatedTarget "cri de chat-associated cry" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Gal-alpha1,4Gal-beta1,4-Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200047 ; owl:annotatedTarget "Inflammation of the cartilage of the external ear." . [] oboInOwl:hasDbXref , "PMID:21642056" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200049 ; owl:annotatedTarget "Increased muscle tone observed in the arms of the affected person." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200050 ; owl:annotatedTarget "Bracket shaped end part of long bone of hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Galalpha1,4Gal-beta1,4Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200053 ; owl:annotatedTarget "Shortening of a leg affecting only one side." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Galalpha1-4Gal-beta1-4Glc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200055 ; owl:annotatedTarget "Disproportionately small hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200055 ; owl:annotatedTarget "Disproportionately small hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200055 ; owl:annotatedTarget "Small hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Galalpha1-4Gal-beta1-4Glc~OH" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200055 ; owl:annotatedTarget "Small hands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200056 ; owl:annotatedTarget "Scar tissue in the macula." . [] oboInOwl:hasDbXref "PMID:23520419", "PMID:32491607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200057 ; owl:annotatedTarget "An aberrant pupillary response characterized by (i) Constriction of pupils of both eyes when the light stimulus is applied to the normal eye, and (ii) Dilatation of pupils of both eyes when the light stimulus is rapidly transferred from the normal eye (after brief light exposure to the normal eye) to the affected eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200057 ; owl:annotatedTarget "Relative afferent pupil defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200057 ; owl:annotatedTarget "Relative afferent pupillary defect" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "Pk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200064 ; owl:annotatedTarget "Asymmetry between the two irides or asymmetry between different parts of one iris." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:29463897" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "WURCS=2.0/3,3,2/[a2122h-1x_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200067 ; owl:annotatedTarget "Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200067 ; owl:annotatedTarget "Spontaneous abortion, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200068 ; owl:annotatedTarget "Decreased visual acuity, nonprogressive" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200070 ; owl:annotatedTarget "Wasting of the outer part of the retina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200072 ; owl:annotatedTarget "Intermittent episodes of paralysis of all four limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200072 ; owl:annotatedTarget "Quadriplegia, episodic" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_60948 ; owl:annotatedTarget "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200083 ; owl:annotatedTarget "Severe limb shortening" . [] oboInOwl:hasDbXref "PMID:27746622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200084 ; owl:annotatedTarget "Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200084 ; owl:annotatedTarget "Giant cell hepatitis on biopsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200084 ; owl:annotatedTarget "Giant cell hepatitis on liver biopsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200084 ; owl:annotatedTarget "Giant cell hepatitis shown on biopsy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200085 ; owl:annotatedTarget "Involuntary shaking of limb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200085 ; owl:annotatedTarget "Limb tremor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200085 ; owl:annotatedTarget "Tremor of limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200096 ; owl:annotatedTarget "A facial appearance characterized by a permanently or nearly permanently opened mouth, in which the upper lip is tented in a way that the opened mouth has the appearance of a triangle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200096 ; owl:annotatedTarget "Triangular-shaped open mouth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "EC 3.5.1.98 (histone deacetylase) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Blisters arising in the mouth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Blebs of oral mucosa" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Blisters of mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Bullae of oral mucosa" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Oral mucosal blisters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200097 ; owl:annotatedTarget "Oral mucosa blisters" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "EC 3.5.1.98 inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200098 ; owl:annotatedTarget "Lack of skin pigmentation (coloring)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200098 ; owl:annotatedTarget "Absent skin pigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200098 ; owl:annotatedTarget "Lack of skin coloration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "EC 3.5.1.98 inhibitors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200101 ; owl:annotatedTarget "Decreased/absent ankle reflexes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200101 ; owl:annotatedTarget "Decreased or absent ankle reflexes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200102 ; owl:annotatedTarget "Sparse or absent eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200102 ; owl:annotatedTarget "Partial to total absence of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200102 ; owl:annotatedTarget "Sparse to absent eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDAC inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200104 ; owl:annotatedTarget "Absence of nail of little finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200104 ; owl:annotatedTarget "Absent fifth fingernail" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200104 ; owl:annotatedTarget "Absent nail of fifth finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDAC inhibitors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200105 ; owl:annotatedTarget "Absent fifth toenail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200105 ; owl:annotatedTarget "Missing fifth toenail" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200109 ; owl:annotatedTarget "Respiratory cilia have shortened or absent outer dynein arms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200113 ; owl:annotatedTarget "Aphalangy, hands and feet" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDACi" . [] oboInOwl:hasDbXref "PMID:29493916" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200114 ; owl:annotatedTarget "Metabolic alkalosis is defined as a disease state where the pH is elevated to greater than 7.45 secondary to some metabolic process." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200118 ; owl:annotatedTarget "Malabsorption of cyanocobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200118 ; owl:annotatedTarget "Vitamin B12 deficiency caused by intestinal malabsorption" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200119 ; owl:annotatedTarget "Acute liver inflammation" . [] oboInOwl:hasDbXref "PMID:7418593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200120 ; owl:annotatedTarget "Chronic hepatitis associated with recurrent clinical exacerbations, extrahepatic manifestations, and progression to cirrhosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200120 ; owl:annotatedTarget "Hepatitis, chronic active" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200122 ; owl:annotatedTarget "Atypical or prolonged liver inflammation" . [] oboInOwl:hasDbXref "https://patient.info/doctor/chronic-hepatitis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200123 ; owl:annotatedTarget "Hepatitis that lasts for more than six months." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200123 ; owl:annotatedTarget "Chronic liver inflammation" . [] oboInOwl:hasDbXref "PMID:23440042" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200124 ; owl:annotatedTarget "Chronic hepatitis associated with infection by cryptosporidia, as demonstrated (for example) by immunohistochemistry of liver tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDACis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200124 ; owl:annotatedTarget "Hepatitis, chronic, due to cryptosporidium infection" . [] oboInOwl:hasDbXref "PMID:27402624" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200127 ; owl:annotatedTarget "Any complex of structural, architectural, contractile or electrophysiological changes affecting the atria with the potential to produce clinically relevant manifestations." . [] oboInOwl:hasDbXref "PMID:28740584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200128 ; owl:annotatedTarget "Thickening of the heart walls in both ventricles." . [] oboInOwl:hasDbXref "PMID:21590624", "PMID:23213494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200134 ; owl:annotatedTarget "A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200136 ; owl:annotatedTarget "Oral pharyngeal dysphagia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200136 ; owl:annotatedTarget "Oropharyngeal dysphagia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200141 ; owl:annotatedTarget "Conical microdontia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200141 ; owl:annotatedTarget "Small, cone shaped teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200141 ; owl:annotatedTarget "Small, peg shaped teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200141 ; owl:annotatedTarget "Small, pointed teeth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:31951767" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDI" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200143 ; owl:annotatedTarget "Bone marrow biopsy shows megaloblastic erythroid hyperplasia" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200146 ; owl:annotatedTarget "An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200146 ; owl:annotatedTarget "MEMA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "HDIs" . [] oboInOwl:hasDbXref , "PMID:13729575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200147 ; owl:annotatedTarget "A reduction in the number of nerve cells in the basal ganglia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200148 ; owl:annotatedTarget "Abnormal liver function tests during pregnancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200148 ; owl:annotatedTarget "Abnormal liver function tests during pregnancy, resolves postpartum" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200149 ; owl:annotatedTarget "An increased lymphocyte count in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200150 ; owl:annotatedTarget "Increased serum bile acid concentration during pregnancy, resolves" . [] oboInOwl:hasDbXref , "PMID:21668033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0200151 ; owl:annotatedTarget "Multifocal dense infiltrates of mast cells in cutaneous tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone amidohydrolase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200153 ; owl:annotatedTarget "Failure of development of lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200153 ; owl:annotatedTarget "Absence of lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200153 ; owl:annotatedTarget "Missing lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone amidohydrolase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200154 ; owl:annotatedTarget "Failure of development of mandibular lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200154 ; owl:annotatedTarget "Absence of lower lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200154 ; owl:annotatedTarget "Absence of mandibular lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone deacetylase (EC 3.5.1.98) inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200154 ; owl:annotatedTarget "Missing lower lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200154 ; owl:annotatedTarget "Missing mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200158 ; owl:annotatedTarget "Failure of development of permanent mandibular lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone deacetylase (EC 3.5.1.98) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200158 ; owl:annotatedTarget "Absence of adult mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200158 ; owl:annotatedTarget "Absence of permanent mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200158 ; owl:annotatedTarget "Missing adult lower lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200158 ; owl:annotatedTarget "Missing permanent mandibular lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone deacetylase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Agenesis of deciduous mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Failure of development of deciduous mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Failure of development of primary mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Absence of deciduous mandibular lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Absence of lower front baby tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Absence of primary mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Missing deciduous mandibular lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200159 ; owl:annotatedTarget "Missing primary mandibular lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61115 ; owl:annotatedTarget "histone deacetylase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Failure of development of maxillary incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Failure of development of upper incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Absence of upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Absence of maxillary incisor" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61313 ; owl:annotatedTarget "a C21-steroid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Missing upper front tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200160 ; owl:annotatedTarget "Missing upper incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Agenesis of lower incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Failure of development of mandibular incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Absence of lower front tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Absence of lower incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Absence of mandibular incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Missing lower front tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0200161 ; owl:annotatedTarget "Missing lower incisor" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:33586561" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "3-hydroxy carboxylic acids" . [] oboInOwl:hasDbXref "PMID:19125436", "eom:96d8ca16a3c80216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Increased vertical distance from the vermillion border of the lower lip to the inferior-most point of the chin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Increased height of chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Increased height of menton region" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Long chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Tall chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Vertical excess of chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Vertical hyperplasia of chin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "3-hydroxycarboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0400000 ; owl:annotatedTarget "Long lower third of face" . [] oboInOwl:hasDbXref "PMID:19125436", "eom:8a5493c72e0dd13c" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Vertical crease fold situated below the vermilion border of the lower lip and above the fatty pad of the chin with the face at rest." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Chin with vertical crease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Chin with vertical furrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Chin with vertical groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Chin with vertical sulcus" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Cleft chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Vertical chin skin cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400001 ; owl:annotatedTarget "Vertical menton crease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "3-hydroxycarboxylic acids" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:40563f1f62db2319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400002 ; owl:annotatedTarget "Folds or ridges within the concha that are distinct from the crus helix." . [] oboInOwl:hasDbXref "PMID:19152421", "eom:5b0e213b31288acd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400003 ; owl:annotatedTarget "Absence of a localized portion of the ear that cannot be described by a more precise term (e.g., absent ear lobe)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "beta-hydroxy carboxylic acid" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:2028381d5c61842a" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400004 ; owl:annotatedTarget "Median longitudinal ear length greater than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400004 ; owl:annotatedTarget "Long ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400004 ; owl:annotatedTarget "Long ears" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "beta-hydroxy carboxylic acids" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:2cff5ac9b681fc73" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400005 ; owl:annotatedTarget "Median longitudinal ear length less than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400005 ; owl:annotatedTarget "Short ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0400005 ; owl:annotatedTarget "Short ears" . [] oboInOwl:hasDbXref "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400007 ; owl:annotatedTarget "Frequent menses; menstrual cycles lasting less than 21 days." . [] oboInOwl:hasDbXref "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0400008 ; owl:annotatedTarget "Prolonged/excessive menses and bleeding at irregular intervals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "beta-hydroxycarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410000 ; owl:annotatedTarget "Abnormality of vomer bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61355 ; owl:annotatedTarget "beta-hydroxycarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410005 ; owl:annotatedTarget "Cleft bony palate" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410005 ; owl:annotatedTarget "Cleft of hard palate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61360 ; owl:annotatedTarget "globosides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410006 ; owl:annotatedTarget "Abnormality of the first branch of the internal carotid artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410006 ; owl:annotatedTarget "Ophthalmic artery anomaly" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61409 ; owl:annotatedTarget "dihydroxyphenylacetic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410008 ; owl:annotatedTarget "Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410008 ; owl:annotatedTarget "Abnormality of the peripheral nervous system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410009 ; owl:annotatedTarget "Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:33704575" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61469 ; owl:annotatedTarget "polyanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410010 ; owl:annotatedTarget "Any abnormality of the somatic nerve plexus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410011 ; owl:annotatedTarget "Any abnormality of the masticatory muscle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61469 ; owl:annotatedTarget "polyanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410012 ; owl:annotatedTarget "Any abnormality of the mouth floor." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410012 ; owl:annotatedTarget "Abnormality of the floor of mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410012 ; owl:annotatedTarget "Abnormality of the mouth floor" . [] oboInOwl:hasDbXref , "https://www.dartmouth.edu/~humananatomy/part_8/chapter_49.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410013 ; owl:annotatedTarget "Any abnormality of the submandibular region, the region between the mandible and the hyoid bone contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61660 ; owl:annotatedTarget "an organic sulfamic acid anion" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/Ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410014 ; owl:annotatedTarget "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61660 ; owl:annotatedTarget "organic sulfamic acid anions" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/Ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410015 ; owl:annotatedTarget "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/Ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410016 ; owl:annotatedTarget "An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium." . [] oboInOwl:hasDbXref , "http://search.medscape.com/search/?q=otitis%20externa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410017 ; owl:annotatedTarget "Inflammation or infection of the external auditory canal (EAC), the auricle, or both." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410017 ; owl:annotatedTarget "Swimmer's ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410018 ; owl:annotatedTarget "Increased susceptibility to ear infections, as manifested by recurrent episodes of ear infections." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410018 ; owl:annotatedTarget "Frequent ear infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410018 ; owl:annotatedTarget "Recurrent ear infections" . [] oboInOwl:hasDbXref , "https://www.healthgrades.com/symptoms/epigastric-pain" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410019 ; owl:annotatedTarget "Pain that is localized to the region of the upper abdomen immediately below the ribs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61697 ; owl:annotatedTarget "FA derivative" . [] oboInOwl:hasDbXref "http://www.medicinenet.com/fish_odor_syndrome_trimethylaminuria/article.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylamine (TMA) in the urine, sweat, and breath of affected individuals." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Fish odour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Fishy body odor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Fishy body odour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Fishy odor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410020 ; owl:annotatedTarget "Fishy odour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410021 ; owl:annotatedTarget "Musty odor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410021 ; owl:annotatedTarget "Musty odour" . [] oboInOwl:hasDbXref "PMID:16086821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410022 ; owl:annotatedTarget "A fish odor in the vaginal area, that is characteristic of bacterial vaginosis (BV), and is due to trimethylamine (TMA)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410022 ; owl:annotatedTarget "Vaginal fish odor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61697 ; owl:annotatedTarget "FA derivatives" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410022 ; owl:annotatedTarget "Vaginal fish odour" . [] oboInOwl:hasDbXref "PMID:26850880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410023 ; owl:annotatedTarget "An anomalous amount or location of cell junction proteins such as plakoglobin or Cx43." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_61697 ; owl:annotatedTarget "fatty acid derivatives" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410030 ; owl:annotatedTarget "Cleft lip" . [] oboInOwl:hasDbXref "http://www.cleftline.org/who-we-are/what-we-do/publications/submucous-clefts/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410031 ; owl:annotatedTarget "Soft and hard-palate submucous clefts are characterized by bony defects in the midline of the soft and hard palate that are covered by the lining (ie mucous membrane) of the roof of the mouth." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62031 ; owl:annotatedTarget "MetaCyc:Polar-amino-acids" . [] oboInOwl:hasDbXref "MP:0000598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410042 ; owl:annotatedTarget "Any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:34067694" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62031 ; owl:annotatedTarget "a polar amino acid" . [] oboInOwl:hasDbXref "MP:0002151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410043 ; owl:annotatedTarget "Any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0410049 ; owl:annotatedTarget "An abnormality of the radial ray; the thumb bones and 1st meta carpel." . [] oboInOwl:hasDbXref "PMID:16731998", "PMID:17659063", "PMID:9357814" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410050 ; owl:annotatedTarget "A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues." . [] oboInOwl:hasDbXref "http://www.hmdb.ca/metabolites/HMDB0002712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410050 ; owl:annotatedTarget "Decreased level of 1,5-AG in serum" . [] oboInOwl:hasDbXref "http://www.hmdb.ca/metabolites/HMDB0002712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410050 ; owl:annotatedTarget "Decreased level of 1,5-anhydroglucitol in serum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62081 ; owl:annotatedTarget "1,1-di-unsubstituted alkanesulfonate" . [] oboInOwl:hasDbXref "PMID:15505778", "PMID:23705938" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410051 ; owl:annotatedTarget "The concentration of 3-hydroxy-3-methylglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62081 ; owl:annotatedTarget "1,1-di-unsubstituted alkanesulfonates" . [] oboInOwl:hasDbXref "PMID:18636793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410052 ; owl:annotatedTarget "An increase in the level of allantoin in the serum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62081 ; owl:annotatedTarget "1,1-diunsubstituted alkanesulfonates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62488 ; owl:annotatedTarget "signal molecule" . [] oboInOwl:hasDbXref "PMID:1485027", "PMID:25485164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410053 ; owl:annotatedTarget "An increase in the level of Gamma-aminobutyric acid (GABA) in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410053 ; owl:annotatedTarget "Increased circulating GABA concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410053 ; owl:annotatedTarget "Increased level of GABA in serum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62488 ; owl:annotatedTarget "signal molecules" . [] oboInOwl:hasDbXref "PMID:1485027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410054 ; owl:annotatedTarget "A decrease in the level of GABA in the serum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62488 ; owl:annotatedTarget "signaling molecule" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410055 ; owl:annotatedTarget "A decrease in the level of erythritol in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62488 ; owl:annotatedTarget "signaling molecules" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410056 ; owl:annotatedTarget "Concentration of erythritol in the cerebrospinal fluid below the lower limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62488 ; owl:annotatedTarget "signalling molecules" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:8689392" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410057 ; owl:annotatedTarget "An increase in the level of D-threitol in the plasma." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62499 ; owl:annotatedTarget "PMID:17030019" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410058 ; owl:annotatedTarget "An increase in the level of D-threitol in the cerebrospinal fluid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62499 ; owl:annotatedTarget "PMID:19747846" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410059 ; owl:annotatedTarget "An increase in the level of D-threitol in the urine." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62499 ; owl:annotatedTarget "PMID:19933331" . [] oboInOwl:hasDbXref "PMID:2576290", "PMID:29099052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410060 ; owl:annotatedTarget "A decrease in the level of D-mannose in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62499 ; owl:annotatedTarget "methyl-branched fatty acids" . [] oboInOwl:hasDbXref "PMID:11092512", "PMID:7671965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410061 ; owl:annotatedTarget "An increase in the level of galactitol in the plasma." . [] oboInOwl:hasDbXref "PMID:11092512", "PMID:7671965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410062 ; owl:annotatedTarget "An increase in the level of galactitol in the urine." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "MetaCyc:CPD-12826" . [] oboInOwl:hasDbXref "PMID:14680973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410063 ; owl:annotatedTarget "An increase in the level of galactonate in the red blood cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410063 ; owl:annotatedTarget "Increased level of galactonate in RBCs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "PMCID:PMC8181341" . [] oboInOwl:hasDbXref "PMID:14680973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410064 ; owl:annotatedTarget "An increase in the level of galactitol in the red blood cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "PMID:34051149" . [] oboInOwl:hasDbXref "PMID:22626821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410065 ; owl:annotatedTarget "An increase in the level of hippuric acid in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:9029640" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate(2-)" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "folate" . [] oboInOwl:hasDbXref "PMID:19551947", "PMID:22626821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410066 ; owl:annotatedTarget "An increase in the level of hippuric acid in the urine." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "folate" . [] oboInOwl:hasDbXref "PMID:2311216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410067 ; owl:annotatedTarget "An increase in the level of L-fucose in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "pteroyl-L-glutamate" . [] oboInOwl:hasDbXref "PMID:3426740" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410069 ; owl:annotatedTarget "An increase in the level of propylene glycol in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "pteroyl-L-monoglutamate" . [] oboInOwl:hasDbXref "PMID:14988808", "PMID:26054712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410070 ; owl:annotatedTarget "An increase in the level of ribitol in the urine. Ribotol is a crystalline pentose alcohol (C5H12O5) and is a metabolic end product formed by the reduction of ribose." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62501 ; owl:annotatedTarget "pteroylglutamate" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410071 ; owl:annotatedTarget "An increase in the level of ribitol in the cerebral spinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62643 ; owl:annotatedTarget "anionic phospholipids" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410072 ; owl:annotatedTarget "An increase in the level of ribose in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62643 ; owl:annotatedTarget "phospholipid anion" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410073 ; owl:annotatedTarget "An increase in the level of ribose in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62643 ; owl:annotatedTarget "phospholipid anions" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410074 ; owl:annotatedTarget "An increase in the level of xylitol in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:9928418" . [] oboInOwl:hasDbXref "PMID:14988808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410075 ; owl:annotatedTarget "An increase in the level of xylitol in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62761 ; owl:annotatedTarget "tyrosine derivatives" . [] oboInOwl:hasDbXref "PMID:10094443", "PMID:4557757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410132 ; owl:annotatedTarget "An increase in the level of L-pyroglutamic acid in the urine." . [] oboInOwl:hasDbXref "PMID:25807072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410133 ; owl:annotatedTarget "Urticaria characterized by spontaneously recurring hives for 6 weeks or longer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62803 ; owl:annotatedTarget "fuel additives" . [] oboInOwl:hasDbXref "PMID:25807072" ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410133 ; owl:annotatedTarget "CIU" . [] oboInOwl:hasDbXref "PMID:25807072" ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410133 ; owl:annotatedTarget "CSU" . [] oboInOwl:hasDbXref "PMID:25807072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410133 ; owl:annotatedTarget "Chronic spontaneous urticaria" . [] oboInOwl:hasDbXref "PMID:11702618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410134 ; owl:annotatedTarget "Urticaria caused by physical agents, such as heat, cold, light, friction." . [] oboInOwl:hasDbXref "PMID:11702618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410135 ; owl:annotatedTarget "Urticaria may be caused by cold temperatures." . [] oboInOwl:hasDbXref "PMID:22346281" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410136 ; owl:annotatedTarget "A form of physical urticaria, in which contact with water, regardless of its temperature and source, evokes pruritic follicular wheals on the skin." . [] oboInOwl:hasDbXref "PMID:29315482" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410137 ; owl:annotatedTarget "Urticaria in response to exposure to ultraviolet-A (UVA), ultraviolet-B (UVB), visible and rarely infrared light." . [] oboInOwl:hasDbXref "PMID:26841242" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410138 ; owl:annotatedTarget "Urticaria in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum." . [] oboInOwl:hasDbXref "PMID:7400473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410139 ; owl:annotatedTarget "Anaphylaxis after physical activity." . [] oboInOwl:hasDbXref "PMID:29359854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410144 ; owl:annotatedTarget "An abnormality in the biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62803 ; owl:annotatedTarget "fuel enhancer" . [] oboInOwl:hasDbXref "PMID:29359854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410145 ; owl:annotatedTarget "Concentration of biotinidase in the blood circulation below the lower limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." . [] oboInOwl:hasDbXref "PMID:29359854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410146 ; owl:annotatedTarget "Concentration of biotinidase in the blood circulation above the upper limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." . [] oboInOwl:hasDbXref , "PMID:23904840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410147 ; owl:annotatedTarget "Infiltration of eosinophils in the stomach mucosa, that is diagnosed by an upper endoscopy and microscopy that shows more than 20 eosinophils per high-power field in association with peripheral eosinophilia and the absence of secondary cause of eosinophilia." . [] oboInOwl:hasDbXref "PMID:28890861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410148 ; owl:annotatedTarget "A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment." . [] oboInOwl:hasDbXref "PMID:29135486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410149 ; owl:annotatedTarget "A form of anaphylaxis that is triggered by intake of drugs or medications." . [] oboInOwl:hasDbXref "PMID:27158535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410151 ; owl:annotatedTarget "Infiltration of numerous eosinophils (usually greater than 15 per high power field) into the squamous epithelium of the esophagus, and layering of eosinophils on the surface layer of the esophagus." . [] oboInOwl:hasDbXref "PMID:27158535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410152 ; owl:annotatedTarget "The formation of small localized collection of eosinophiles (an eosinophilic microabscess) in the esophagus. Usually clusters of greater than or equal to 4 eosinophils are seen, that appear as exudates or white spots or white plaques." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410152 ; owl:annotatedTarget "Eosinophilic micro-abscess formation in the oesophagus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62868 ; owl:annotatedTarget "antihepatotoxic agent" . [] oboInOwl:hasDbXref "PMID:16828325", "PMID:19343532", "PMID:3571488", "PMID:6616873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410153 ; owl:annotatedTarget "The concentration of methylsuccinic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62868 ; owl:annotatedTarget "hepatoprotective agents" . [] oboInOwl:hasDbXref "PMID:16828325", "PMID:19343532", "PMID:3571488", "PMID:6616873" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410153 ; owl:annotatedTarget "Increased level of pyrotartaric acid in urine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62868 ; owl:annotatedTarget "hepatoprotector" . [] oboInOwl:hasDbXref "PMID:22024767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410154 ; owl:annotatedTarget "An increase in the level of myristic acid in the serum." . [] oboInOwl:hasDbXref "PMID:7398077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410156 ; owl:annotatedTarget "An increase in the level of N-acetylneuraminic acid in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_62937 ; owl:annotatedTarget "icosanoid anion" . [] oboInOwl:hasDbXref "PMID:11992753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410157 ; owl:annotatedTarget "An increase in the level of N-acetylneuraminic acid in cultured fibroblasts." . [] oboInOwl:hasDbXref "GO:0036297", "PMID:16464006", "PMID:22064477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410166 ; owl:annotatedTarget "A defect in the of the process of interstrand cross-link repair: removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62937 ; owl:annotatedTarget "eicosanoid anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0410167 ; owl:annotatedTarget "Muscle issues in the chest" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "Reaxys:87671" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62937 ; owl:annotatedTarget "eicosanoid anions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0410168 ; owl:annotatedTarget "Muscle issues in the back" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62937 ; owl:annotatedTarget "icosanoid anions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410169 ; owl:annotatedTarget "Muscle issues in the shoulder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62943 ; owl:annotatedTarget "prostanoid anions" . [] oboInOwl:hasDbXref "PMID:15452153" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410174 ; owl:annotatedTarget "An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction." . [] oboInOwl:hasDbXref "PMID:27036365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410175 ; owl:annotatedTarget "An increase in the level of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410175 ; owl:annotatedTarget "Increased level of ketone bodies in blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62944 ; owl:annotatedTarget "sialic acid anions" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410176 ; owl:annotatedTarget "Abnormal G6PD level" . [] oboInOwl:hasDbXref "PMID:24787449" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410177 ; owl:annotatedTarget "An anomaly in the level of glucose-6-phosphate dehydrogenase in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410177 ; owl:annotatedTarget "Abnormal G6PD level in blood" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_62978 ; owl:annotatedTarget "4-hydroxypyrrolidine-2-carboxylate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410178 ; owl:annotatedTarget "Increased G6PD level in blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62978 ; owl:annotatedTarget "4-hydroxyproline anion" . [] oboInOwl:hasDbXref "PMID:24787449" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410179 ; owl:annotatedTarget "A decrease in the level of glucose-6-phosphate dehydrogenase in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410179 ; owl:annotatedTarget "Decreased G6PD level in blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62978 ; owl:annotatedTarget "hydroxyprolinate" . [] oboInOwl:hasDbXref "PMID:28479150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410180 ; owl:annotatedTarget "An anomaly in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410180 ; owl:annotatedTarget "Abnormal G6PD level in dried blood spot" . [] oboInOwl:hasDbXref "PMID:28479150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410181 ; owl:annotatedTarget "An increase in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410181 ; owl:annotatedTarget "Increased G6PD level in dried blood spot" . [] oboInOwl:hasDbXref "PMID:28479150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410182 ; owl:annotatedTarget "A decrease in the level of glucose-6-phosphate dehydrogenase in a dried blood spot." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410182 ; owl:annotatedTarget "Decreased G6PD level in dried blood spot" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "Carnosine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62978 ; owl:annotatedTarget "hydroxyproline anion" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/B978-0-12-383834-6.00086-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410183 ; owl:annotatedTarget "An anomaly in the level of glucose-6-phosphate dehydrogenase in leukocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410183 ; owl:annotatedTarget "Abnormal G6PD level in leukocytes" . [] oboInOwl:hasDbXref "PMID:18942156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410184 ; owl:annotatedTarget "An anomaly in the level of glucose-6-phosphate dehydrogenase in red blood cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410184 ; owl:annotatedTarget "Abnormal G6PD level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410184 ; owl:annotatedTarget "Abnormal G6PD level in red blood cells" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_62981 ; owl:annotatedTarget "Reaxys:4742919" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410185 ; owl:annotatedTarget "Abnormal G6PD level in tissue" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_62981 ; owl:annotatedTarget "(2S)-4-hydroxypyrrolidine-2-carboxylate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410186 ; owl:annotatedTarget "Increased G6PD level in tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_62981 ; owl:annotatedTarget "4-hydroxy-L-proline anion" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410187 ; owl:annotatedTarget "Decreased G6PD level in tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63046 ; owl:annotatedTarget "emulgent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63046 ; owl:annotatedTarget "emulgents" . [] oboInOwl:hasDbXref "PMID:18942156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410188 ; owl:annotatedTarget "A decrease in the level of glucose-6-phosphate dehydrogenase in red blood cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410188 ; owl:annotatedTarget "Decreased G6PD level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410188 ; owl:annotatedTarget "Decreased G6PD level in red blood cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63046 ; owl:annotatedTarget "emulsifiers" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410189 ; owl:annotatedTarget "Increased G6PD level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410189 ; owl:annotatedTarget "Increased G6PD level in red blood cells" . [] oboInOwl:hasDbXref "https://doi.org/10.1016/B978-0-12-383834-6.00086-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410190 ; owl:annotatedTarget "A decrease in the level of glucose-6-phosphate dehydrogenase in leukocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410190 ; owl:annotatedTarget "Decreased G6PD level in leukocytes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "N(alpha)-(beta-alanyl)-L-histidine" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63070 ; owl:annotatedTarget "Reaxys:3536336" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410191 ; owl:annotatedTarget "Increased G6PD level in leukocytes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_63070 ; owl:annotatedTarget "3-aminopropanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63070 ; owl:annotatedTarget "beta-alaninate anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63070 ; owl:annotatedTarget "beta-alaninate(1-)" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_63137 ; owl:annotatedTarget "4-hydroxypyrrolidinium-2-carboxylate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410196 ; owl:annotatedTarget "Abnormal UDP-glucose 4-epimerase level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410196 ; owl:annotatedTarget "Abnormal UDP-glucose 4-epimerase level in red blood cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63161 ; owl:annotatedTarget "glycosyl compounds" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410197 ; owl:annotatedTarget "Increased UDP-glucose 4-epimerase level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410197 ; owl:annotatedTarget "Increased UDP-glucose 4-epimerase level in red blood cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidant" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410198 ; owl:annotatedTarget "Decreased UDP-glucose 4-epimerase level in RBCs" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410198 ; owl:annotatedTarget "Decreased UDP-glucose 4-epimerase level in red blood cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidants" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidiser" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410199 ; owl:annotatedTarget "Elevated CSF urate concentration" . [] oboInOwl:hasDbXref "PMID:22206545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410204 ; owl:annotatedTarget "An increase in the length of time required for food to pass through the intestines." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidisers" . [] oboInOwl:hasDbXref "PMID:3243933" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0410205 ; owl:annotatedTarget "Nicotinuric acid is an acyl glycine, which are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Nicotinuric acid is the major detoxification product of nicotinic acid. It may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid." . [] oboInOwl:hasDbXref "PMID:10027825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410208 ; owl:annotatedTarget "Detection of cotinine, an alkaloid found in tobacco and the predominant metabolite of nicotine, in plasma or serum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidising agents" . [] oboInOwl:hasDbXref "PMID:15581159" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410209 ; owl:annotatedTarget "A reduced concentration of folic acid, which is also known as vitamin B9 in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:7926229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410210 ; owl:annotatedTarget "An abnormality in any umbilical cord measurement performed after birth, such as the blood gas level." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidizer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidizers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410212 ; owl:annotatedTarget "High cord blood oxygen level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidizing agent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410213 ; owl:annotatedTarget "Low cord blood oxygen level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63248 ; owl:annotatedTarget "oxidizing agents" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410214 ; owl:annotatedTarget "High cord blood carbon dioxide level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63299 ; owl:annotatedTarget "carbohydrate derivatives" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410215 ; owl:annotatedTarget "Low cord blood carbon dioxide level" . [] oboInOwl:hasDbXref , "https://www.researchgate.net/publication/277918795_Nonsyndromic_oligodontia_A_rare_case_report" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410218 ; owl:annotatedTarget "Abnormally small dimension of the maxilla (upper jaw) relative to the mandible (lower jaw)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410219 ; owl:annotatedTarget "Abnormally small dimension of the mandible (lower jaw) relative to the maxilla (upper jaw)." . [] oboInOwl:hasDbXref "PMID:26433529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410220 ; owl:annotatedTarget "Increased level of IgE antibody against dairy proteins, including casein, alpha-lactalbumin, beta-lactoglobulin or bovine serum albumin contained in cow, sheep or goat milk and milk products." . [] oboInOwl:hasDbXref "PMID:8543754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410221 ; owl:annotatedTarget "Increased level of IgE antibody against animal proteins, such as albumins that are present in animal hair, dander, shed skin, saliva and urine." . [] oboInOwl:hasDbXref "PMID:14719162" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410222 ; owl:annotatedTarget "Increased level of IgE antibody against seafood, including fish, shrimp, lobster, crab, squid and abalone." . [] oboInOwl:hasDbXref "https://www.atsjournals.org/doi/abs/10.1164/arrd.1982.125.1.80" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410223 ; owl:annotatedTarget "Increased level of IgE antibody against dust mites, such as house dust mites." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63299 ; owl:annotatedTarget "derivatised carbohydrate" . [] oboInOwl:hasDbXref "PMID:7835691" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410225 ; owl:annotatedTarget "Increased level of IgE antibody against a drug or class of drugs, such as antibiotics." . [] oboInOwl:hasDbXref "PMID:9534914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410226 ; owl:annotatedTarget "Increased level of IgE antibody against feathers, which could be indicative of an allergy against feathers themselves, or mite allergens present in feathers." . [] oboInOwl:hasDbXref "PMID:23229594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410227 ; owl:annotatedTarget "Increased level of IgE antibody against proteins found in foods, such as milk, egg, soy, wheat, peanut, treenut, fish, and shellfish." . [] oboInOwl:hasDbXref "PMID:26549334" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410228 ; owl:annotatedTarget "Increased level of IgE antibody against a plant based food allergen, including vegetables and fruits." . [] oboInOwl:hasDbXref "PMID:25788950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410229 ; owl:annotatedTarget "Increased level of IgE antibody against gluten, a protein found in wheat, barley, and rye." . [] oboInOwl:hasDbXref "PMID:12915766", "PMID:23229594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410230 ; owl:annotatedTarget "Increased level of IgE antibody against nut food products such as peanuts or tree nuts, such as hazelnuts, walnuts, cashews, and almonds." . [] oboInOwl:hasDbXref "PMID:11591198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410231 ; owl:annotatedTarget "Increased level of IgE antibody against eggs, including egg whites, egg yolks, and egg proteins such as ovoalbumin and ovomucoid." . [] oboInOwl:hasDbXref "PMID:12402012" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410232 ; owl:annotatedTarget "Increased level of IgE antibody against fungus, such as molds like zygomycota, ascomycota and deuteromycota." . [] oboInOwl:hasDbXref "PMID:30182427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410233 ; owl:annotatedTarget "Increased level of IgE antibody against meat, such as mammalian meat, including beef or pork, or poultry, like duck or chicken." . [] oboInOwl:hasDbXref "https://doi.org/10.1007/s40475-015-0058-7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410234 ; owl:annotatedTarget "Increased level of IgE antibody against parasites, such as helminths (parasitic worms, such as Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenalis, Necator americanus, Strongyloides stercoralis) or parasites such as Toxoplasma gondii." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "Karnozin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63299 ; owl:annotatedTarget "derivatised carbohydrates" . [] oboInOwl:hasDbXref "PMID:21913205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410235 ; owl:annotatedTarget "Increased level of IgE antibody against antigens from insects such as moths, mosquitos, or cockroaches." . [] oboInOwl:hasDbXref "PMID:21913205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410236 ; owl:annotatedTarget "Increased level of IgE antibody against venom from insects such as bees, wasps, hornets, yellowjackets." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63299 ; owl:annotatedTarget "derivatized carbohydrate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63299 ; owl:annotatedTarget "derivatized carbohydrates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63353 ; owl:annotatedTarget "disaccharide derivatives" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63367 ; owl:annotatedTarget "monosaccharide derivatives" . [] oboInOwl:hasDbXref "PMID:29986992" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410249 ; owl:annotatedTarget "Increased level of IgE antibody against galactose-alpha-1, 3 galactose (alpha-gal), a carbohydrate found in mammalian meat." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63394 ; owl:annotatedTarget "ketoaldonic acid derivatives" . [] oboInOwl:hasDbXref "PMID:8614468" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410251 ; owl:annotatedTarget "An abnormality in the cleavage of L-selectin during the process of guiding neutrophils to the site of infection. Proteolytic cleavage of L-selectin results in rapid shedding from the cell surface, which has a role in neutrophil rolling and accumulation at the site of infection." . [] oboInOwl:hasDbXref "PMID:23953336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410252 ; owl:annotatedTarget "Neutropenia with an absolute neutrophil count (ANC) less than 1,500,000,000/L lasting for more than 3 months." . [] oboInOwl:hasDbXref "PMID:23233578" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410253 ; owl:annotatedTarget "Chornic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow." . [] oboInOwl:hasDbXref "PMID:23233578" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410254 ; owl:annotatedTarget "Cyclic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow." . [] oboInOwl:hasDbXref "PMID:23953336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410255 ; owl:annotatedTarget "A transient reduction in the number of neutrophils in the peripheral blood. Transient neutropenia is most commonly associated with viral infections, but other causes include drugs and autoimmunity." . [] oboInOwl:hasDbXref "PMID:23953336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410256 ; owl:annotatedTarget "Transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan." . [] oboInOwl:hasDbXref "PMID:27543669" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410257 ; owl:annotatedTarget "An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus." . [] oboInOwl:hasDbXref "PMID:24050624" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410258 ; owl:annotatedTarget "An increased number of neutrophils circulating in the blood in the absence of an infection. Factors contributing to neutrophilia could include inflammation or congenital disorders." . [] oboInOwl:hasDbXref "PMID:28196822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410259 ; owl:annotatedTarget "Fusion of the liver with the lung." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "Karnozzn" . [] oboInOwl:hasDbXref "PMID:29701087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410260 ; owl:annotatedTarget "The presence of an asymmetrical gluteal crease, the horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg." . [] oboInOwl:hasDbXref "PMID:26167022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410262 ; owl:annotatedTarget "A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves." . [] oboInOwl:hasDbXref "PMID:30174006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410264 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, located in the airway, typically below the vocal chords, that can cause severe obstruction of the airway." . [] oboInOwl:hasDbXref "PMID:16866116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410265 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, located in the upper part of the larynx (voice box) including the epiglottis; the area above the vocal cords." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.epsc.2014.06.004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410266 ; owl:annotatedTarget "A hemangioma arising from within visceral structures, the internal organs of the body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63436 ; owl:annotatedTarget "carbohydrate acid derivatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410267 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, located in the intestines, which includes the bowel." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410267 ; owl:annotatedTarget "Intestinal hemangiomas" . [] oboInOwl:hasDbXref "PMID:11307096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410268 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the spleen." . [] oboInOwl:hasDbXref "http://www.jpss.eu/index.php/current-issue/item/457-forty-four-cases-of-labial-hemangioma-therapeutic-management" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410269 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the upper lip." . [] oboInOwl:hasDbXref "PMID:10626176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410270 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the esophagus." . [] oboInOwl:hasDbXref "PMID:28419860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410271 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the glottic or supraglottic regions." . [] oboInOwl:hasDbXref "PMID:29980161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410272 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the vulva." . [] oboInOwl:hasDbXref "PMID:26011223", "UBERON:0035619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410273 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the retropharyngeal space, the portion of the peripharyngeal space that is located posterior to the pharynx." . [] oboInOwl:hasDbXref "http://ispub.com/IJOS/11/1/8101#" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410274 ; owl:annotatedTarget "A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the paraspinal muscular region, the muscles next to the spine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63470 ; owl:annotatedTarget "sulfur-containing amino-acid anions" . [] oboInOwl:hasDbXref "PMID:25449217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410275 ; owl:annotatedTarget "A spinal cord hemangioma located in the lumbosacral spine region." . [] oboInOwl:hasDbXref "PMID:24075092", "https://www.chw.org/medical-care/birthmarks-and-vascular-anomalies-center/conditions/phace-syndrome/phace-syndrome-handbook/ventral-or-midline-abnormalities" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410276 ; owl:annotatedTarget "An abnormality of the sternum that presents at birth as a ventral sternal non-union defect, due to an abnormality of the fusion of the layers of the skin. It presents as a scar-like line that extends upward from the umbilicus (belly button)." . [] oboInOwl:hasDbXref "https://www.chw.org/medical-care/birthmarks-and-vascular-anomalies-center/conditions/phace-syndrome/phace-syndrome-handbook/ventral-or-midline-abnormalities" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410277 ; owl:annotatedTarget "A sternal pit is a small indentation or dimple in the skin overlying the sternum of the chest. In some cases, the skin defect can be linear, extending several inches over the sternum." . [] oboInOwl:hasDbXref "https://www.chop.edu/conditions-diseases/pituitary-cysts" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410278 ; owl:annotatedTarget "A fluid-filled sacs that develop on or near the pituitary gland." . [] oboInOwl:hasDbXref "DOI:10.1530/endoabs.44.EP82" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410279 ; owl:annotatedTarget "Partial or complete wasting (loss) of the pituitary gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410280 ; owl:annotatedTarget "Onset of disease manifestations before adulthood, defined here as before the age of 16 years, but excluding neonatal or congenital onset." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63471 ; owl:annotatedTarget "branched-chain amino-acid anions" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410280 ; owl:annotatedTarget "Paediatric onset" . [] oboInOwl:hasDbXref "PMID:23399526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410281 ; owl:annotatedTarget "A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410281 ; owl:annotatedTarget "Indigestion" . [] oboInOwl:hasDbXref "NCIT:C16284" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410282 ; owl:annotatedTarget "A deviation from the normal concentration of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands." . [] oboInOwl:hasDbXref "PubChem:18804" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410284 ; owl:annotatedTarget "Detection of norpropoxyphene in the blood, a major metabolite of the opioid analgesic drug dextropropoxyphene." . [] oboInOwl:hasDbXref "PubChem:23897" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410286 ; owl:annotatedTarget "Detection of molindone in the blood, an antipyschotic used for treatment of schizophrenia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63473 ; owl:annotatedTarget "aromatic amino-acid anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63477 ; owl:annotatedTarget "iodothyroninates" . [] oboInOwl:hasDbXref "PMID:28754582", "PMID:30262571" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410291 ; owl:annotatedTarget "Opposing or not responding to instructions or external stimuli." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410292 ; owl:annotatedTarget "Abnormal level of natural antibody to blood group agents" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410292 ; owl:annotatedTarget "Abnormal natural antibody level to blood group antigens in blood (isohemagglutinin)" . [] oboInOwl:hasDbXref "PMID:25309532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410293 ; owl:annotatedTarget "Absent or undetectable level of isohemagglutinin. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "L-carnosine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "GnRH agonist" . [] oboInOwl:hasDbXref "PMID:26018535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410294 ; owl:annotatedTarget "A reduced ability to synthesize postvaccination antibodies against proteins in vaccines, as measured by antibody titer determination following vaccination." . [] oboInOwl:hasDbXref "PMID:26018535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410299 ; owl:annotatedTarget "A reduced ability to synthesize postvaccination antibodies against polysaccharides in vaccines, as measured by antibody titer determination following vaccination." . [] oboInOwl:hasDbXref "PMID:26018535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410302 ; owl:annotatedTarget "A reduced ability to synthesize postvaccination antibodies against protein-conjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "GnRH agonists" . [] oboInOwl:hasDbXref , "PMID:117247" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410309 ; owl:annotatedTarget "The concentration of alpha-aminoadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "GnRH-A" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410310 ; owl:annotatedTarget "An abnormal form or size of neutrophils in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410311 ; owl:annotatedTarget "Hyposegmented (hypolobulated) or bilobed neutrophil nuclei in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410312 ; owl:annotatedTarget "An excessive division of the lobes of the nucleus of a neutrophil in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "gonadotrophin releasing hormone agonist" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "gonadotrophin releasing hormone agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410313 ; owl:annotatedTarget "Abnormal concentration of 1-methylhistidine in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63533 ; owl:annotatedTarget "gonadotropin releasing hormone agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410314 ; owl:annotatedTarget "Decreased concentration of 1-methylhistidine in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:21822758" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410315 ; owl:annotatedTarget "Increased concentration of 1-methylhistidine in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:21993877" . [] oboInOwl:hasDbXref , "PMID:6780020", "PMID:6790901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410316 ; owl:annotatedTarget "Abnormal amount of 3-methylhistidine in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22005599" . [] oboInOwl:hasDbXref , "PMID:6780020", "PMID:6790901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410317 ; owl:annotatedTarget "Increased concentration of 3-methylhistidine in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22082101" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "N-(3-aminopropanoyl)-L-histidine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22153577" . [] oboInOwl:hasDbXref , "PMID:6790901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410318 ; owl:annotatedTarget "Decreased concentration of 3-methylhistidine in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410319 ; owl:annotatedTarget "Alpha-gal allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410320 ; owl:annotatedTarget "Animal protein allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410321 ; owl:annotatedTarget "Animal dander allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410322 ; owl:annotatedTarget "Bacteria allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410323 ; owl:annotatedTarget "Drug allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410324 ; owl:annotatedTarget "Dust mite allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410326 ; owl:annotatedTarget "Feather allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410327 ; owl:annotatedTarget "Dairy allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410328 ; owl:annotatedTarget "Egg allergy" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22213370" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410329 ; owl:annotatedTarget "Gluten allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410330 ; owl:annotatedTarget "Meat allergen allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410330 ; owl:annotatedTarget "Meat allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410331 ; owl:annotatedTarget "Nut allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410331 ; owl:annotatedTarget "Nut food product allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410332 ; owl:annotatedTarget "Plant based food allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410333 ; owl:annotatedTarget "Seafood allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410334 ; owl:annotatedTarget "Fungal allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410334 ; owl:annotatedTarget "Fungi allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410334 ; owl:annotatedTarget "Fungus allergy" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22218931" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410335 ; owl:annotatedTarget "Insect allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410336 ; owl:annotatedTarget "Venom allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410337 ; owl:annotatedTarget "Parasite allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410338 ; owl:annotatedTarget "Plant product allergy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410339 ; owl:annotatedTarget "Insect bite allergy" . [] oboInOwl:hasDbXref "PMID:23204755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410340 ; owl:annotatedTarget "The occurrence of multiple or unique whitish or normal in color small papules or nodules in oral cavity, especially on labial and buccal mucosa, lower lip and tongue, and less often on the upper lip, gingiva and palate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22342987" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410341 ; owl:annotatedTarget "An abnormal level of heparan sulfate in the blood." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410341 ; owl:annotatedTarget "Abnormal circulating heparan sulphate level" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410341 ; owl:annotatedTarget "Abnormality of the concentration of heparan sulphate in the blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "PMID:22371656" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "monoamines" . [] oboInOwl:hasDbXref , "PMID:9692391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410342 ; owl:annotatedTarget "An abnormal increase in the concentration of heparan sulfate in the blood." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410342 ; owl:annotatedTarget "Increased blood heparan sulphate concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410342 ; owl:annotatedTarget "Increased circulating heparan sulphate level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "naturally occurring monoamine" . [] oboInOwl:hasDbXref , "PMID:23514715" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410343 ; owl:annotatedTarget "An abnormal decrease in the concentration of heparan sulfate in the blood." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410343 ; owl:annotatedTarget "Decreased blood heparan sulphate concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0410343 ; owl:annotatedTarget "Decreased circulating heparan sulphate level" . [] oboInOwl:hasDbXref , "PMID:18199743" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410344 ; owl:annotatedTarget "Decreased length of O-fucosylated glycans present on properdin." . [] oboInOwl:hasDbXref , "PMID:23676310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410345 ; owl:annotatedTarget "An abnormal increase in the concentration of polyhexose in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63534 ; owl:annotatedTarget "naturally occurring monoamines" . [] oboInOwl:hasDbXref , "PMID:23676310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410346 ; owl:annotatedTarget "An abnormal increase in the concentration of galactosylated oligosaccharides in urine." . [] oboInOwl:hasDbXref , "PMID:23676310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410347 ; owl:annotatedTarget "An abnormal increase in the concentration of high-mannose-type oligosaccharides in the urine." . [] oboInOwl:hasDbXref , "PMID:23676310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410348 ; owl:annotatedTarget "An abnormal increase in the concentration of multiantennary sialylated oligosaccharides in the urine." . [] oboInOwl:hasDbXref , "PMID:16385447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410349 ; owl:annotatedTarget "An abnormal decrease in glycosyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase enzymatic level." . [] oboInOwl:hasDbXref , "PMID:25251875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410350 ; owl:annotatedTarget "An abnormal increase in the concentrationl of small fucosylated oligosaccharides in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410351 ; owl:annotatedTarget "An abnormal concentration of complex N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410352 ; owl:annotatedTarget "An abnormal increase in the concentration of complex N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:21385794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410353 ; owl:annotatedTarget "An abnormal decrease in the concentration of complex N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410354 ; owl:annotatedTarget "An abnormal increase in the concentration of sialylated N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:23430903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410355 ; owl:annotatedTarget "An abnormal decrease in the concentration of sialylated N-glycans on glycoproteins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410356 ; owl:annotatedTarget "An abnormal concentration of high-mannose N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:23928051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410357 ; owl:annotatedTarget "An abnormal increase in the concentration of high-mannose N-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410358 ; owl:annotatedTarget "An abnormal decrease in the concentration of high-mannose N-glycans on glycoproteins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410359 ; owl:annotatedTarget "An abnormal in the concentration of core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:14578315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410360 ; owl:annotatedTarget "An abnormal increase in the concentration of core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "N-2-M" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63551 ; owl:annotatedTarget "carbohydrate acid anion derivative" . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410361 ; owl:annotatedTarget "An abnormal decrease in the concentration of core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref "PMID:21930648" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410362 ; owl:annotatedTarget "Hypoglycosylation of alpha-dystroglycan with O-mannosyl glycans. Alpha-dystroglycan is a functional target of O-mannosyl glycosylation and functional glycosylation of alpha-DG is essential in its interaction with the extracellular matrix." . [] oboInOwl:hasDbXref , "PMID:25142811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410363 ; owl:annotatedTarget "An abnormal increase in the concentration of monosialylated core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410364 ; owl:annotatedTarget "An abnormal decrease in the concentration of monosialylated core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63551 ; owl:annotatedTarget "carbohydrate acid anion derivatives" . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410365 ; owl:annotatedTarget "An abnormal increase in the concentration of disialylated core 1 O-glycans on glycoproteins." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410366 ; owl:annotatedTarget "An abnormal increase in the concentration of globoside Gb4." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63551 ; owl:annotatedTarget "carbohydrate acid derivative anions" . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410368 ; owl:annotatedTarget "An abnormal increase in the concentration of glycolipid globoside Gb3." . [] oboInOwl:hasDbXref , "PMID:24026681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410370 ; owl:annotatedTarget "The absence of ganglioside GM3." . [] oboInOwl:hasDbXref , "PMID:16251947" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410372 ; owl:annotatedTarget "An abnormal increase in the concentration of Tn antigen on glycoproteins." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63561 ; owl:annotatedTarget "ketoaldonate derivatives" . [] oboInOwl:hasDbXref "PMID:22474485" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410373 ; owl:annotatedTarget "Any abnormality in the proportion of naive CD4 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "PMID:26700072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410374 ; owl:annotatedTarget "Any abnormality in the proportion of naive CD8 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63563 ; owl:annotatedTarget "O-glycosylglycoside derivative" . [] oboInOwl:hasDbXref "PMID:22474485" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0410375 ; owl:annotatedTarget "An abnormally increased proportion of naive CD4 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "PMID:26700072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410376 ; owl:annotatedTarget "An abnormally increased proportion of naive CD8 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "PMID:26700072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410377 ; owl:annotatedTarget "An abnormally reduced proportion of naive CD8 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63563 ; owl:annotatedTarget "O-glycosylglycoside derivatives" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63563 ; owl:annotatedTarget "oligosaccharide derivatives" . [] oboInOwl:hasDbXref "PMID:22474485" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410378 ; owl:annotatedTarget "An abnormally reduced proportion of naive CD4 T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "CL:0000897" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410379 ; owl:annotatedTarget "An abnormal proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "N-beta-alanyl-L-histidine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63571 ; owl:annotatedTarget "trisaccharide derivatives" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:28481945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410380 ; owl:annotatedTarget "An abnormal proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410381 ; owl:annotatedTarget "An abnormal proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63726 ; owl:annotatedTarget "neuroprotectant" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63726 ; owl:annotatedTarget "neuroprotectants" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410383 ; owl:annotatedTarget "An abnormal proportion of effector memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_63726 ; owl:annotatedTarget "neuroprotective agents" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410384 ; owl:annotatedTarget "An abnormal proportion of central memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64047 ; owl:annotatedTarget "food additives" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64049 ; owl:annotatedTarget "acidity regulator" . [] oboInOwl:hasDbXref "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410385 ; owl:annotatedTarget "Decreased proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64049 ; owl:annotatedTarget "acidity regulators" . [] oboInOwl:hasDbXref "CL:0000897" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410386 ; owl:annotatedTarget "Decresaed proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410388 ; owl:annotatedTarget "A reduced proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64049 ; owl:annotatedTarget "food acidity regulators" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64049 ; owl:annotatedTarget "pH control agent" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410389 ; owl:annotatedTarget "A reduced proportion of CD8-positive, alpha-beta central memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64049 ; owl:annotatedTarget "pH control agents" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410390 ; owl:annotatedTarget "A reduced proportion of CD8-positive, alpha-beta effector memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "Nalpha-(beta-alanyl)-L-histidine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64365 ; owl:annotatedTarget "aralkylamino compounds" . [] oboInOwl:hasDbXref "CL:0000897" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410391 ; owl:annotatedTarget "An abnormally elevated proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410392 ; owl:annotatedTarget "An abnormally elevated proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410393 ; owl:annotatedTarget "An abnormally elevated proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410394 ; owl:annotatedTarget "An abnormally elevated proportion of effector memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "CAS:24003-67-6" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410395 ; owl:annotatedTarget "An increased proportion of effector memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410396 ; owl:annotatedTarget "An increased proportion of central memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref , "PMID:20037680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410397 ; owl:annotatedTarget "Saccular dilatation of the terminal bronchioles." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "Reaxys:1773416" . [] oboInOwl:hasDbXref "MP:0000647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410400 ; owl:annotatedTarget "Absence of the sebaceous gland, the holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0410401 ; owl:annotatedTarget "Applies to a sign or symptom that is exacerbated in the evening as compared to the day." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "N-hexanoylglycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "An abnormality of the frontal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "Abnormality of the bone of the forehead" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "Abnormal morphology of frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "Anomaly of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "Deformity of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430000 ; owl:annotatedTarget "Malformation of the frontal bone" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "n-Hexanoylglycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430002 ; owl:annotatedTarget "An abnormality of the lacrimal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430002 ; owl:annotatedTarget "Anomaly of the lacrimal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430002 ; owl:annotatedTarget "Deformity of the lacrimal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430002 ; owl:annotatedTarget "Malformation of the lacrimal bone" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "Caproylglycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430003 ; owl:annotatedTarget "An abnormality of the palatine bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430003 ; owl:annotatedTarget "Anomaly of the palatine bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430003 ; owl:annotatedTarget "Deformity of the palatine bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430003 ; owl:annotatedTarget "Malformation of the palatine bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "beta-alanyl-L-histidine" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "Hexanoylglycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430005 ; owl:annotatedTarget "An abnormality of the ethmoid bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430005 ; owl:annotatedTarget "Anomaly of the ethmoid bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430005 ; owl:annotatedTarget "Deformity of the ethmoid bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430005 ; owl:annotatedTarget "Malformation of the ethmoid bone" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "N-(1-oxohexyl)glycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG", "http://www.eyecareforanimals.com/animal-eye-conditions/general/251-distichiasis-trichiasis-ectopic-cilia.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430006 ; owl:annotatedTarget "An eyelash that emerges from the underside (conjunctiva) of the upper or lower eyelid." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG", "http://en.wikipedia.org/wiki/Symblepharon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430007 ; owl:annotatedTarget "A partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430007 ; owl:annotatedTarget "Eyelid adhesion to globe of eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430007 ; owl:annotatedTarget "Eyelid stuck to eyeball" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64390 ; owl:annotatedTarget "N-caproylglycine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430008 ; owl:annotatedTarget "The presence of more than the normal number of eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430008 ; owl:annotatedTarget "Extra eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430008 ; owl:annotatedTarget "Double eyelid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430009 ; owl:annotatedTarget "Developmental hypoplasia of the eyelid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0430009 ; owl:annotatedTarget "Small eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430009 ; owl:annotatedTarget "Decreased size of eyelid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_64554 ; owl:annotatedTarget "2-azaniumyl-3-(1H-indol-3-yl)propanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430009 ; owl:annotatedTarget "Underdevelopment of eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430009 ; owl:annotatedTarget "Short eyelid" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/microblepharia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430010 ; owl:annotatedTarget "Abnormal shortness of the vertical dimensions of the eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430010 ; owl:annotatedTarget "Abnormally small eyelid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64554 ; owl:annotatedTarget "2-ammonio-3-(1H-indol-3-yl)propanoate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430011 ; owl:annotatedTarget "An abnormality of the palpebral conjunctiva." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430012 ; owl:annotatedTarget "Failure to complete ossification (maturation and calcification) of the palatine bone." . _:genid105653 oboInOwl:hasDbXref ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430012 ; owl:annotatedTarget "Incomplete calcification of palatine bone" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001682 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430012 ; owl:annotatedTarget "Incomplete mineralization of palatine bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0430012 ; owl:annotatedTarget "Incomplete formation of palatine bone" . [] oboInOwl:creation_date ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0430013 ; owl:annotatedTarget _:genid105653 . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GOC_MG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430013 ; owl:annotatedTarget "Lack of formation of the palatine bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430013 ; owl:annotatedTarget "Absence of palatine bone calcification" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430013 ; owl:annotatedTarget "Absence of palatine bone mineralization" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_64558 ; owl:annotatedTarget "2-azaniumyl-4-(methylsulfanyl)butanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0430013 ; owl:annotatedTarget "Absence of palatine bone formation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430014 ; owl:annotatedTarget "An abnormality of one or more of the five muscles of the soft palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430015 ; owl:annotatedTarget "An abnormality of any of the muscles of the pharynx." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64558 ; owl:annotatedTarget "2-ammonio-4-(methylsulfanyl)butanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430016 ; owl:annotatedTarget "An abnormality of the tensor veli palatini muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430017 ; owl:annotatedTarget "An abnormality of the uvular muscle" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64558 ; owl:annotatedTarget "methionine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430018 ; owl:annotatedTarget "An abnormality of the muscles of the structure of the nose." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430018 ; owl:annotatedTarget "Abnormality of muscle of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430018 ; owl:annotatedTarget "Abnormality of musculature of the nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430018 ; owl:annotatedTarget "Abnormality of nasal musculature" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "beta-alanyl-L-histidine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430019 ; owl:annotatedTarget "An abnormality of any of the muscles of facial expression, which are innervated by the seventh (VII) cranial nerve and control facial expression." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430019 ; owl:annotatedTarget "Abnormality of muscle of facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430020 ; owl:annotatedTarget "An abnormality of the levator labii superioris alaeque nasi muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430021 ; owl:annotatedTarget "An abnormality of the common carotid arteries, which provide the arterial supply to the head and neck and give rise to the internal carotid artery and the external carotid artery." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430021 ; owl:annotatedTarget "Abnormality of the common carotid artery" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430022 ; owl:annotatedTarget "An abnormality of the sphenoid sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The sphenoid sinus is located within the sphenoid bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430023 ; owl:annotatedTarget "An abnormality of the maxillary sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The maxillary sinus is located within the skeleton of the midface, lateral to the nasal cavity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430023 ; owl:annotatedTarget "Abnormality of the upper jaw sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430024 ; owl:annotatedTarget "An abnormality of an external jugular vein of the neck." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Two-sided or bilateral weakness of the muscles of facial expression and eye closure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Bilateral facial muscle paralysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Bilateral facial muscle weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Bilateral facial paralysis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Paralysis of both sides of the face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430025 ; owl:annotatedTarget "Weakness of both sides of the face" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "EC 2.1.2.1 inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Big maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Big upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Hyperplasia of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Increased size of maxilla" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "EC 2.1.2.1 inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Increased size of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Large maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Large upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Maxillary excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Maxillary hyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Maxillary macrognathia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Maxillary prominence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Prominent maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Prominent upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Upper jaw bone excess" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "L-serine hydroxymethyltransferase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Upper jaw excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Increased projection of maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Increased projection of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Hypertrophy of maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Hypertrophy of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0430028 ; owl:annotatedTarget "Maxillary prognathia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "L-serine hydroxymethyltransferase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively large in size compared to the other parts of the maxilla or other facial structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Hyperplasia of the intermaxillary bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Hyperplasia of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Increased size of premaxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Increased size of the primary palate bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Large premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Large primary palate bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "L-threonine aldolase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Premaxillary excess" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0430029 ; owl:annotatedTarget "Primary palate bone excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "A perceived unpleasant smell given off by the body." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "BO" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "Body odor" . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/1072342-overview" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "Bromhidrosis" . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/1072342-overview" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "Bromidrosis" . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/1072342-overview" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500001 ; owl:annotatedTarget "Osmidrosis" . [] oboInOwl:hasDbXref "http://www.mayoclinic.org/symptoms/anal-pain/basics/definition/sym-20050918" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500005 ; owl:annotatedTarget "Pain in and around the anus or rectum (perianal region)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500005 ; owl:annotatedTarget "Anal pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "L-threonine aldolase inhibitors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500005 ; owl:annotatedTarget "Rectal pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "allothreonine aldolase inhibitor" . [] oboInOwl:hasDbXref "PMID:26220178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500006 ; owl:annotatedTarget "Inflammation of the urethra." . [] oboInOwl:hasDbXref "PMID:27843899", "PMID:7575269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500007 ; owl:annotatedTarget "Multiple cysts along the pupillary margin that appear as spherical or tear-drop-shaped pigmented lesions or wrinkled masses emerging from the pupillary border of the iris." . [] oboInOwl:hasDbXref "PMID:27843899" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500007 ; owl:annotatedTarget "Iris flocculi cause little, if any, visual impairment in most cases. However, they are occasionally associated with dissecting aortic aneurysm due to a shared mutation in smooth muscle that affects both the iris and the aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500008 ; owl:annotatedTarget "Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500008 ; owl:annotatedTarget "Cornea verticillata can be a feature of Fabry disease and can occur as an adverse effect of mediciations including amiodarone." . [] oboInOwl:hasDbXref "PMID:11073535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500009 ; owl:annotatedTarget "It is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0500009 ; owl:annotatedTarget "LDD" . [] oboInOwl:hasDbXref "PMID:11073535" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500009 ; owl:annotatedTarget "Often associated with Cowden syndrome." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "ignotine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "allothreonine aldolase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500011 ; owl:annotatedTarget "A rounded, puffy face with fat deposits in the temporal fossa and cheeks, a double chin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500011 ; owl:annotatedTarget "Moon face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500011 ; owl:annotatedTarget "Puffy face" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500012 ; owl:annotatedTarget "A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone (GnRH). Intermittent GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500012 ; owl:annotatedTarget "Abnormality of GnRH level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500013 ; owl:annotatedTarget "Secretion of gonadotropin-releasing hormone that does not occur in a pulsatile fashion." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500017 ; owl:annotatedTarget "Abnormal cardiac cath" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0500018 ; owl:annotatedTarget "Abnormal exercise test" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500018 ; owl:annotatedTarget "Abnormal treadmill test" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitors" . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/2009552-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500019 ; owl:annotatedTarget "Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2)." . [] oboInOwl:hasDbXref "https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=cardiac_biomarkers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500020 ; owl:annotatedTarget "Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes." . [] oboInOwl:hasDbXref , "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500021 ; owl:annotatedTarget "An decreased level of gamma-aminobutyric acid in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "glycine hydroxymethyltransferase inhibitor" . [] oboInOwl:hasDbXref "PMID:27979632" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500022 ; owl:annotatedTarget "A deviation from the normal concentration of dehydroepiandrosterone in the circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500022 ; owl:annotatedTarget "Abnormal serum DHEA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "glycine hydroxymethyltransferase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine aldolase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine aldolase inhibitors" . [] oboInOwl:hasDbXref "PMID:20460383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500028 ; owl:annotatedTarget "Deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500028 ; owl:annotatedTarget "CWPs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine hydroxymethylase inhibitor" . [] oboInOwl:hasDbXref "PMID:26835382" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500030 ; owl:annotatedTarget "Change in normal glycogen storage content." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine hydroxymethylase inhibitors" . [] oboInOwl:hasDbXref "PMID:21120491" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500031 ; owl:annotatedTarget "An elevation in bone density in one or more carpal bones of the hand." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine hydroxymethyltransferase inhibitor" . [] oboInOwl:hasDbXref "PMID:20404840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500032 ; owl:annotatedTarget "Abnormality of the structure and branching of the dendrites of a neuron." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "CAS:305-84-0" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine hydroxymethyltransferase inhibitors" . [] oboInOwl:hasDbXref "PMID:17203310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500034 ; owl:annotatedTarget "Blockage of the nasolacrimal sac." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine transhydroxymethylase inhibitor" . [] oboInOwl:hasDbXref "PMID:13434546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500035 ; owl:annotatedTarget "A mass of granulation tissue in response to chronic dacryocystitis as polypoid formations or they follow accidental injury, from probing and as a reaction to retained foreign bodies in the sac." . [] oboInOwl:hasDbXref "PMID:4352147" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500036 ; owl:annotatedTarget "Benign tumor of the nasolacrimal sac." . [] oboInOwl:hasDbXref "PMID:16253035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500037 ; owl:annotatedTarget "The malignant epithelial neoplasm with papillary growths in the nasolacrimal sac." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500039 ; owl:annotatedTarget "An abnormality of the conjuctiva and ocular surface caused by conjunctival inflammation and associated with scarring." . [] oboInOwl:hasDbXref "PMID:25586714" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500040 ; owl:annotatedTarget "A benign tumor composed of adipose tissue and dense connective tissue usually located near the temporal fornix." . [] oboInOwl:hasDbXref "https://www.aoa.org/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500041 ; owl:annotatedTarget "A condition where one or both of the two principal meridians focus in the front of the retina when the eye is at rest." . [] oboInOwl:hasDbXref "PMID:8719687", "https://www.aao.org/bcscsnippetdetail.aspx?id=03ad3eb3-3445-4be2-9470-2c4845169b75" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500043 ; owl:annotatedTarget "With the eyes in primary position, the sclera is visible above the superior corneal limbus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "serine transhydroxymethylase inhibitors" . [] oboInOwl:hasDbXref "PMID:7735674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500044 ; owl:annotatedTarget "An elevation of the eyelid above the normal level in the primary position." . [] oboInOwl:hasDbXref "PMID:17323781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500045 ; owl:annotatedTarget "A unilateral or bilateral eyelid retraction due to midbrain lesions." . [] oboInOwl:hasDbXref "PMID:10777824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500046 ; owl:annotatedTarget "Inflammation of the eyelid due to overactivity of the sebaceous gland." . [] oboInOwl:hasDbXref "PMID:10777824" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500046 ; owl:annotatedTarget "There is some suggestion that yeast bacterial strain called Malassezia furfur may cause seborrhoeic dermatitis. This yeast bacterial strain thrives in the oil of human skin especially in adults." . [] oboInOwl:hasDbXref , "PMID:9392338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500047 ; owl:annotatedTarget "A type of lymphoma that involves the nasolacrimal sac." . [] oboInOwl:hasDbXref "PMID:11222337" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500048 ; owl:annotatedTarget "A very common condition in which the extreme end of the nasolacrimal duct underneath the inferior turbinate fails to complete its canalization in the newborn period." . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9", "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500049 ; owl:annotatedTarget "An avascular or abnormally vascularized retina that occurs in premature infants and can lead to blindness." . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9", "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500050 ; owl:annotatedTarget "The retinal vessels stop and then a linear flat white line is present that usually runs the circumference of the vascular retina." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500050 ; owl:annotatedTarget "ROP stage 1" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500051 ; owl:annotatedTarget "The accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "threonine aldolase inhibitor" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500051 ; owl:annotatedTarget "ROP stage 2" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500052 ; owl:annotatedTarget "The neovascularization accumulates at the edge of the vascularized retina and extends into the vitreous (also called extra retinal fibrosis proliferation). In cases of Zone 2 and Zone 3, this may be sausage shaped. In more posterior Zone 1 disease, the stage 3 can appear as a direct extension of the normal retinal vessels but extending tangentially over the avascular retina." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500052 ; owl:annotatedTarget "ROP stage 3" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500053 ; owl:annotatedTarget "Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500053 ; owl:annotatedTarget "ROP stage 4" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500054 ; owl:annotatedTarget "A detachment that involves the peripheral retina that does not extend into the macula." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500054 ; owl:annotatedTarget "ROP stage 4a" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500055 ; owl:annotatedTarget "A detachment that involves the peripheral retina that involves the macula itself. The detachment usually starts in the temporal periphery although can also involve the nasal retina as well." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500055 ; owl:annotatedTarget "ROP 4b" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500056 ; owl:annotatedTarget "Funnel detachment from the retina with generally traction in all four quadrants." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64570 ; owl:annotatedTarget "threonine aldolase inhibitors" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500056 ; owl:annotatedTarget "ROP stage 5" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500057 ; owl:annotatedTarget "An open funnel detachment of the retina with generally traction in all four quadrants." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500057 ; owl:annotatedTarget "ROP stage 5a" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500058 ; owl:annotatedTarget "A closed funnel detachment of the retina with generally traction in all four quadrants." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500058 ; owl:annotatedTarget "ROP stage 5b" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9", "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500059 ; owl:annotatedTarget "Retinopathy which extends from the center of the optic disc to twice the distance from the center of the optic disc to the center of the macula." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500059 ; owl:annotatedTarget "ROP zone 1" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9", "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500060 ; owl:annotatedTarget "Retinopathy which extends centrifugally from the edge of zone I to the nasal ora serrata." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500060 ; owl:annotatedTarget "ROP zone II" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9", "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500061 ; owl:annotatedTarget "Retinopathy which is a residual crescent of retina anterior to zone II." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64571 ; owl:annotatedTarget "N-methyl-D-aspartate receptor agonist" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500061 ; owl:annotatedTarget "ROP zone III" . [] oboInOwl:hasDbXref "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500062 ; owl:annotatedTarget "Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500062 ; owl:annotatedTarget "ROP plus" . [] oboInOwl:hasDbXref "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500063 ; owl:annotatedTarget "As vascular abnormalities of the posterior pole that are insufficient for the diagnosis of plus disease but that demonstrate more arterial tortuosity and more venous dilatation than normal." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500063 ; owl:annotatedTarget "ROP pre-plus" . [] oboInOwl:hasDbXref "PMID:16009843" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500063 ; owl:annotatedTarget "Over time, the vessel abnormalities of pre-plus may progress to frank plus disease as the vessels dilate and become more tortuous." . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500064 ; owl:annotatedTarget "A retinopathy with a 50% likelihood of progressing to retinal detachment. Threshold disease is considered to be present when stage 3 retinopathy of prematurity (ROP) is present in either zone I or zone II, with at least 5 continuous or 8 total clock hours of disease, and the presence of plus disease." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500064 ; owl:annotatedTarget "ROP threshold" . [] oboInOwl:hasDbXref "ISBN:978-3-319-52190-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500065 ; owl:annotatedTarget "High risk patients who were in Zone 1 (no Plus or stage 3) or Zone 2 with Plus or stage 3 but not both." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500065 ; owl:annotatedTarget "ROP prethreshold" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64571 ; owl:annotatedTarget "N-methyl-D-aspartate receptor agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500066 ; owl:annotatedTarget "The difference between total and manifest myopia." . [] oboInOwl:hasDbXref , "ISBN-13:9781416029076" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500069 ; owl:annotatedTarget "A type of ectropion associated with orbicularis muscle weakness caused by cranial nerve VII palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500070 ; owl:annotatedTarget "A conjuctival lesion composed of adipose tissue and dense connective tissue. Such choristomas of dermal elements are normally found at the outer canthus, and have a gelatinous appearance. Classically, there is an indistinct posterior border (with the lesion frequently extending into the orbit) and a well-demarcated anterior border several millimetres posterior to the limbus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500072 ; owl:annotatedTarget "Eccentric fixation in which the angle of eccentricity equals the objective angle of deviation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500073 ; owl:annotatedTarget "Any deviation from the normal ocular alignment." . [] oboInOwl:hasDbXref "ISBN-13:978-0199679980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500074 ; owl:annotatedTarget "An incomitant tendency for an occluded eye to elevate and extort which resolves on uncovering." . [] oboInOwl:hasDbXref , "ISBN-13:978-0199679980" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500074 ; owl:annotatedTarget "Dissociated vertical deviation (DVD) occurs when the level of illumination received by either eye is reduced sufficiently and as a result eye deviates progressively upwards, but reverts to its original position when the level of illumination returns to normally acceptable levels. It may sometimes be so asymmetrical as to be virtually unilateral and is associated with heterotropia usually of early onset." . [] oboInOwl:hasDbXref "PMID:18427617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500075 ; owl:annotatedTarget "A change in horizontal ocular alignment, unrelated to accommodation, that is brought about solely by a change in the balance of visual input from the two eyes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500076 ; owl:annotatedTarget "A type of vertical tropia in which, when one eye is fixing, the other eye is deviated upwards." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500077 ; owl:annotatedTarget "A type of vertical phoria in which, in dissociation, the occluded eye deviates upwards." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64571 ; owl:annotatedTarget "NMDA receptor agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500078 ; owl:annotatedTarget "A type of vertical tropia in which, when one eye is fixing, the other eye is deviated downwards." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500079 ; owl:annotatedTarget "A type of vertical phoria in which, in dissociation, the occluded eye deviates downwards." . [] oboInOwl:hasDbXref "PMID:28358301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500081 ; owl:annotatedTarget "The term pseudophakia refers to having an artificial lens implanted after the natural eye lens has been removed. During cataract surgery the natural cloudy lens is replaced by an pseudophakia intraocular lens (IOL)." . [] oboInOwl:hasDbXref "PMID:24862768" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500086 ; owl:annotatedTarget "Having a characteristic appearance of a slate gray area of pigmentation within the disc margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500086 ; owl:annotatedTarget "Optic nerve grey crescent" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500086 ; owl:annotatedTarget "Temporal grey pigmentary crescent" . [] oboInOwl:hasDbXref "PMID:24862768" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500086 ; owl:annotatedTarget "This type of disc rim pigmentation can create the impression of neuroretinal rim thinning, and thus lead to the misdiagnosis of glaucoma or \"glaucoma suspect\" with attendant implications for overtreatment or unnecessary close monitoring of such patients." . [] oboInOwl:hasDbXref "PMID:20920826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500087 ; owl:annotatedTarget "Thinning in the layers of the retina and retinal pigment epithelium around the optic nerve." . [] oboInOwl:hasDbXref "PMID:24023426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500088 ; owl:annotatedTarget "Loss of pigment in the fovea centralis." . [] oboInOwl:hasDbXref "ISBN-13:978-0199552641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500089 ; owl:annotatedTarget "A benign tumor of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64571 ; owl:annotatedTarget "NMDAR agonist" . [] oboInOwl:hasDbXref "PMID:20616917" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500090 ; owl:annotatedTarget "A capillary hemangioma surrounding the eyeball but within the orbit." . [] oboInOwl:hasDbXref "ISBN-13:978-0199679980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500091 ; owl:annotatedTarget "A hamartoma of lymph vessels that usually presents in childhood. It tends to increase in size with head-down posture and with the Valsalva manoeuvre. Superficial lesions are visible as transilluminable cystic spaces of the lid or conjunctiva that may also contain blood. Deep lesions may cause gradual proptosis or present acutely with orbital pain and reduced vision due to haemorrhage." . [] oboInOwl:hasDbXref "PMID:27069254", "PMID:27069841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500093 ; owl:annotatedTarget "Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500093 ; owl:annotatedTarget "Food allergy" . [] oboInOwl:hasDbXref "PMID:15327474" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500094 ; owl:annotatedTarget "Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis." . [] oboInOwl:hasDbXref "PMID:16461139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500095 ; owl:annotatedTarget "Food-induced anaphylaxis is a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing food." . [] oboInOwl:hasDbXref "PMID:21458655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500096 ; owl:annotatedTarget "A form of anaphylaxis that is triggered by exposure to venom." . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500104 ; owl:annotatedTarget "Abnormal decrease in diastolic blood pressure." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500104 ; owl:annotatedTarget "Decreased diastolic BP" . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500105 ; owl:annotatedTarget "Abnormal decrease in systolic blood pressure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64571 ; owl:annotatedTarget "NMDAR agonists" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500105 ; owl:annotatedTarget "Decreased systolic BP" . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500106 ; owl:annotatedTarget "Elevated systolic blood pressure without an elevated blood pressure." . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500106 ; owl:annotatedTarget "Isolated systolic hypertension or an elevated systolic blood pressure without an elevated diastolic blood pressure is a known risk factor for incident heart failure in older adults." . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500107 ; owl:annotatedTarget "A decrease in diastolic blood pressure (<60 mmHg) without a decrease in systolic blood pressure (> or = to 100 mmHg)." . [] oboInOwl:hasDbXref "PMID:21947466" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500107 ; owl:annotatedTarget "Isolated diastolic hypotension is a risk factor for incident heart failure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500109 ; owl:annotatedTarget "Detection of barbiturate metabolites such as Phenobarbital in urine." . [] oboInOwl:hasDbXref "PMID:26339207" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500109 ; owl:annotatedTarget "Barbiturates are central nervous depressants. They can reduce heart rate, breathing, and blood pressure." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500110 ; owl:annotatedTarget "Positive urine marijuana test" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500110 ; owl:annotatedTarget "Postive urine pot test" . [] oboInOwl:hasDbXref "PMID:21134021" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500110 ; owl:annotatedTarget "Cannabis (marijuana, hashish) is the most widely used illegal drug in the world. The primary psychoactive component in cannabis is delta9-tetrahydrocannabinol (THC), which is rapidly metabolized to equipotent 11-hydroxy-THC (11-OH-THC) and non-psychoactive 11-nor-9-carboxy- delta9-tetrahydrocannabinol (THCCOOH)." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "CAS:305-84-0" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_64577 ; owl:annotatedTarget "flour treatment agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500114 ; owl:annotatedTarget "Abnormal concentration of urobilinogen present in the stool." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500115 ; owl:annotatedTarget "An increased amount of urobilinogen present in the stool." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500115 ; owl:annotatedTarget "Urobilinogen is formed from the reduction of bilirubin. An increased amount of urobilinogen in the urine may be indicative of liver disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500116 ; owl:annotatedTarget "Detection of barbiturate metabolites such as Phenobarbital in blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64577 ; owl:annotatedTarget "dough improver" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500117 ; owl:annotatedTarget "Abnormal concentration of urate in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "PMID:15571231" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500117 ; owl:annotatedTarget "Urate is largely excluded from the brain under non-inflammatory conditions but increases in particular conditions such as Guillain-Barre Syndrome and bacterial meningitis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64577 ; owl:annotatedTarget "dough improvers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500132 ; owl:annotatedTarget "A decreased amount of valine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500132 ; owl:annotatedTarget "Low blood valine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64577 ; owl:annotatedTarget "improving agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64577 ; owl:annotatedTarget "improving agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500133 ; owl:annotatedTarget "An decreased concentration of tyrosine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500133 ; owl:annotatedTarget "Decreased tyrosine in blood" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500133 ; owl:annotatedTarget "Low blood tyrosine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64584 ; owl:annotatedTarget "uremic toxins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500134 ; owl:annotatedTarget "An increased amount of tryptophan in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500134 ; owl:annotatedTarget "High blood tryptophan concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500134 ; owl:annotatedTarget "Increased tryptophan in blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:17504107" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500135 ; owl:annotatedTarget "A decreased amount of tryptophan in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:18758757" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500135 ; owl:annotatedTarget "Decreased tryptophan in blood" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500135 ; owl:annotatedTarget "Low blood tryptophan concentration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:20678516" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500136 ; owl:annotatedTarget "A decreased amount of threonine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500136 ; owl:annotatedTarget "Decreased threonine blood levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500136 ; owl:annotatedTarget "Low blood threonine concentration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:21141920" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500138 ; owl:annotatedTarget "High blood serine levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500138 ; owl:annotatedTarget "Increased serine blood concentration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15727 ; owl:annotatedTarget "PMID:10841274" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:21531289" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "PMID:22177408" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500139 ; owl:annotatedTarget "A decreased amount of proline in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500139 ; owl:annotatedTarget "Decreased blood proline levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500139 ; owl:annotatedTarget "Low blood proline concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "GlyT1 inhibitor" . [] oboInOwl:hasDbXref "PMID:4690509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500140 ; owl:annotatedTarget "A decreased amount of hydroxyproline in the blood." . [] oboInOwl:hasDbXref "PMID:4690509" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500140 ; owl:annotatedTarget "Decreased hydroxyproline in the blood" . [] oboInOwl:hasDbXref "PMID:4690509" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500140 ; owl:annotatedTarget "Low level of hydroxyproline in the blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "GlyT1 inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500141 ; owl:annotatedTarget "A decreased amount of phenylalanine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500141 ; owl:annotatedTarget "Decreased blood phenylalanine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64588 ; owl:annotatedTarget "glycine transporter 1 inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500141 ; owl:annotatedTarget "Low blood phenylalanine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64589 ; owl:annotatedTarget "glycine receptor agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500142 ; owl:annotatedTarget "A decreased amount of lysine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500142 ; owl:annotatedTarget "Decreased blood lysine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500142 ; owl:annotatedTarget "Low blood lysine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64600 ; owl:annotatedTarget "C21-steroid hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500143 ; owl:annotatedTarget "Decreased amount of leucine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500143 ; owl:annotatedTarget "Decreased blood concentration of leucine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500143 ; owl:annotatedTarget "Low blood leucine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64708 ; owl:annotatedTarget "one-carbon compounds" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64709 ; owl:annotatedTarget "organic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500144 ; owl:annotatedTarget "A decreased amount of isoleucine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500144 ; owl:annotatedTarget "Decreased blood isoleucine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500144 ; owl:annotatedTarget "Low blood isoleucine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64767 ; owl:annotatedTarget "anionic groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500145 ; owl:annotatedTarget "A decreased amount of histidine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500145 ; owl:annotatedTarget "Decreased blood histidine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500145 ; owl:annotatedTarget "Low blood histidine levels" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15734 ; owl:annotatedTarget "Primary alcohol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64775 ; owl:annotatedTarget "organic anionic groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500147 ; owl:annotatedTarget "Decreased amount of glutamine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500147 ; owl:annotatedTarget "Decreased blood glutamine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "poisonous agent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500147 ; owl:annotatedTarget "Low blood glutamine level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "poisonous agents" . [] oboInOwl:hasDbXref "PMID:22949847", "PMID:7623444" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500149 ; owl:annotatedTarget "Concentration of glutamate in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500149 ; owl:annotatedTarget "High blood glutamate levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500149 ; owl:annotatedTarget "Increased blood glutamate concentration" . [] oboInOwl:hasDbXref "PMID:22949847" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500149 ; owl:annotatedTarget "Under normal circumstances, plasma glutamate concentration is 5-100 microM/L, the whole blood concentration is 150-300 microM/L while in the brain's ECF it is only 0.3-2 microM/L." . [] oboInOwl:hasDbXref "PMID:22949847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500150 ; owl:annotatedTarget "A decreased amount of glutamate in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500150 ; owl:annotatedTarget "Decreased blood glutamate concentrations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500150 ; owl:annotatedTarget "Low blood glutamate levels" . [] oboInOwl:hasDbXref "PMID:22949847" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500150 ; owl:annotatedTarget "Under normal circumstances, plasma glutamate concentration is 5-100 microM/L, the whole blood concentration is 150-300 microM/L while in the brain's ECF it is only 0.3-2 microM/L." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "poisonous substance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "poisonous substances" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500151 ; owl:annotatedTarget "An increased amount of cystine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500151 ; owl:annotatedTarget "High blood cystine levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500151 ; owl:annotatedTarget "Increased blood cystine concentraions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "poisons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500152 ; owl:annotatedTarget "A decreased amount of cystine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500152 ; owl:annotatedTarget "Decreased blood cystine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500152 ; owl:annotatedTarget "Low blood cystine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "toxic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500153 ; owl:annotatedTarget "An increased amount of arginine levels in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "toxic agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500153 ; owl:annotatedTarget "High blood arginine levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500153 ; owl:annotatedTarget "Increased blood arginine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "toxic substance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500154 ; owl:annotatedTarget "A decreased amount of alanine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500154 ; owl:annotatedTarget "Decreased blood alanine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500154 ; owl:annotatedTarget "Low blood alanine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_64909 ; owl:annotatedTarget "toxic substances" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500155 ; owl:annotatedTarget "Any deviation from the normal concentration of asparagine in the blood circulation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15734 ; owl:annotatedTarget "1-Alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500156 ; owl:annotatedTarget "An increased amount of asparagine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500156 ; owl:annotatedTarget "High blood asaparagine levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500156 ; owl:annotatedTarget "Increased blood asparagine concentration" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_6495 ; owl:annotatedTarget "Lipoprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500157 ; owl:annotatedTarget "A decreased amount of asparagine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500157 ; owl:annotatedTarget "Decreased blood asparagine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500157 ; owl:annotatedTarget "Low blood asparagine levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_6495 ; owl:annotatedTarget "lipoproteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500158 ; owl:annotatedTarget "Any deviation from the normal concentration of aspartate in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_6495 ; owl:annotatedTarget "lipoprotein particle" . [] oboInOwl:hasDbXref "PMID:7353275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500159 ; owl:annotatedTarget "An increased concentration of aspartic acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65023 ; owl:annotatedTarget "anti-asthmatic agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500159 ; owl:annotatedTarget "High blood aspartic acid levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500159 ; owl:annotatedTarget "Increased blood aspartic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65023 ; owl:annotatedTarget "antiasthmatic agent" . [] oboInOwl:hasDbXref , "PMID:20017611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500160 ; owl:annotatedTarget "Any deviation from the normal concentration of carnosine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65023 ; owl:annotatedTarget "antiasthmatic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500161 ; owl:annotatedTarget "An increased amount of carnosine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500161 ; owl:annotatedTarget "High blood carnosine levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500161 ; owl:annotatedTarget "Increased blood carnosine concenrtation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500162 ; owl:annotatedTarget "A decreased amount of carnosine in bood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65212 ; owl:annotatedTarget "polysaccharide derivatives" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500162 ; owl:annotatedTarget "Decreased blood carnosine concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500162 ; owl:annotatedTarget "Low blood carnosine levels" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15734 ; owl:annotatedTarget "a primary alcohol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65255 ; owl:annotatedTarget "food preservatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500163 ; owl:annotatedTarget "An abnormal decrease in ornithine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500163 ; owl:annotatedTarget "Decreased blood ornithine concentrations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500163 ; owl:annotatedTarget "Low blood ornithine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65256 ; owl:annotatedTarget "antimicrobial food preservatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500164 ; owl:annotatedTarget "An abnormality of carbon dioxide (CO2) in the arterial blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500164 ; owl:annotatedTarget "Abnormal CO2 levels in blood" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500164 ; owl:annotatedTarget "Abnormal blood carbon dioxide level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65256 ; owl:annotatedTarget "antimicrobial preservative" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65256 ; owl:annotatedTarget "antimicrobial preservatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500165 ; owl:annotatedTarget "An abnormality of the partial pressure of oxygen in the arterial blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500165 ; owl:annotatedTarget "Abnormal O2 blood concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500165 ; owl:annotatedTarget "Abnormal blood O2 level" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500165 ; owl:annotatedTarget "Abnormal blood oxygen levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500166 ; owl:annotatedTarget "An abnormal concentration of gastrin in the blood." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65296 ; owl:annotatedTarget "a primary amine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500167 ; owl:annotatedTarget "An elevated amount of gastrin in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500167 ; owl:annotatedTarget "Elevated gastrin in the blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_65296 ; owl:annotatedTarget "substituted ammonium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500167 ; owl:annotatedTarget "Increased blood gastrin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500170 ; owl:annotatedTarget "An abnormal amount of acylcarnitine in the urine." . [] oboInOwl:hasDbXref "PMID:23258903" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500170 ; owl:annotatedTarget "Combined, the total daily bile and urine production of acylcarnitine is <200 micromol." . [] oboInOwl:hasDbXref "PMID:23814085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500173 ; owl:annotatedTarget "A loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure." . [] oboInOwl:hasDbXref "PMID:23814085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500173 ; owl:annotatedTarget "Reflex anoxic seizure" . [] oboInOwl:hasDbXref "PMID:23814085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500173 ; owl:annotatedTarget "Reflex anoxic seizures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66873 ; owl:annotatedTarget "C4-dicarboxylic acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15734 ; owl:annotatedTarget "primary alcohols" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_66874 ; owl:annotatedTarget "Reaxys:6337985" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500184 ; owl:annotatedTarget "Any deviation from the normal concentration of amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500184 ; owl:annotatedTarget "Abnormal amino acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_66874 ; owl:annotatedTarget "(2S)-2-(beta-alanylamino)-3-(1H-imidazol-4-yl)propanoate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500185 ; owl:annotatedTarget "Any deviation from the normal concentration of branched-chain amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500185 ; owl:annotatedTarget "Abnormal branched-chain amino acid levels in cerbrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66874 ; owl:annotatedTarget "N(alpha)-(beta-alanyl)-L-histidinate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500186 ; owl:annotatedTarget "Any deviation from the normal concentration of valine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500186 ; owl:annotatedTarget "Abnormal valine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66874 ; owl:annotatedTarget "carnosinate anion" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500187 ; owl:annotatedTarget "Any increased amount from normal of valine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66874 ; owl:annotatedTarget "carnosinate(1-)" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500187 ; owl:annotatedTarget "High valine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500188 ; owl:annotatedTarget "Any decreased amount from normal of valine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500188 ; owl:annotatedTarget "Low valine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500189 ; owl:annotatedTarget "Any deviation from the normal concentration of leucine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500189 ; owl:annotatedTarget "Abnormal leucine levels in cerebrospinal fluid" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_66884 ; owl:annotatedTarget "PMID:9989229" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500190 ; owl:annotatedTarget "Abnormally decreased levels of leucine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500190 ; owl:annotatedTarget "Low leucine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66884 ; owl:annotatedTarget "an N-alkylglycine" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500191 ; owl:annotatedTarget "Abnormally increased levels of leucine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500191 ; owl:annotatedTarget "High leucine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_66916 ; owl:annotatedTarget "2-azaniumylpropanoate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500192 ; owl:annotatedTarget "Any deviation from the normal concentration of isoleucine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500192 ; owl:annotatedTarget "Abnormal isoleucine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66916 ; owl:annotatedTarget "2-ammoniopropanoate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500193 ; owl:annotatedTarget "Abnormally increased levels of isoleucine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500193 ; owl:annotatedTarget "High levels of isoleucine in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_66922 ; owl:annotatedTarget "2-amino-5-(carbamoylamino)pentanoate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500194 ; owl:annotatedTarget "Abnormally decreased levels of isoleucine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500194 ; owl:annotatedTarget "Low levels of isoleucine in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500195 ; owl:annotatedTarget "Any deviation from the normal concentration of glutamine-family amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500195 ; owl:annotatedTarget "Abnormal glutamine family amino acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500196 ; owl:annotatedTarget "Any deviation from the normal concentration of glutamine amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500196 ; owl:annotatedTarget "Abnormal glutamine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_66924 ; owl:annotatedTarget "{[imino(amino)methyl](methyl)amino}acetate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500197 ; owl:annotatedTarget "Abnormally increased levels of glutamine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66924 ; owl:annotatedTarget "(N-methylcarbamimidamido)acetate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500197 ; owl:annotatedTarget "High glutamine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66924 ; owl:annotatedTarget "N-[amino(imino)methyl]-N-methylglycinate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500198 ; owl:annotatedTarget "Abnormally decreased levels of glutamine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500199 ; owl:annotatedTarget "Any deviation from the normal concentration of glutamic acid in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500199 ; owl:annotatedTarget "Abnormal glutamic acid levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_66933 ; owl:annotatedTarget "PMID:9989229" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500200 ; owl:annotatedTarget "Abnormally increased levels of glutamic acid in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500200 ; owl:annotatedTarget "High glutamic acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66933 ; owl:annotatedTarget "N-alkylglycines" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500201 ; owl:annotatedTarget "Abnormally decreased levels of glutamic acid in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500201 ; owl:annotatedTarget "Low glutamic acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_66998 ; owl:annotatedTarget "histidinate derivatives" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500202 ; owl:annotatedTarget "Any deviation from the normal concentration of arginine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500202 ; owl:annotatedTarget "Abnormal arginine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500203 ; owl:annotatedTarget "Abnormally increased levels of arginine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500203 ; owl:annotatedTarget "High arginine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67011 ; owl:annotatedTarget "folate" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500204 ; owl:annotatedTarget "Abnormally decreased levels of arginine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67011 ; owl:annotatedTarget "folate anion" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500204 ; owl:annotatedTarget "Low arginine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67011 ; owl:annotatedTarget "folate anions" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500205 ; owl:annotatedTarget "Any deviation from the normal concentration of aspartate-family amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500206 ; owl:annotatedTarget "Any deviation from the normal concentration of lysine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500206 ; owl:annotatedTarget "Abnormal lysine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67013 ; owl:annotatedTarget "methyl-branched fatty acid anions" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500207 ; owl:annotatedTarget "Abnormally decreased levels of lysine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500207 ; owl:annotatedTarget "Low lysine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67016 ; owl:annotatedTarget "tetrahydrofolate anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67016 ; owl:annotatedTarget "tetrahydrofolate anions" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500209 ; owl:annotatedTarget "Any deviation from the normal concentration of methionine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500209 ; owl:annotatedTarget "Abnormal methionine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67016 ; owl:annotatedTarget "tetrahydrofolates" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500210 ; owl:annotatedTarget "Concentration of methionine in the cerebrospinal fluid above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500210 ; owl:annotatedTarget "High methionine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67079 ; owl:annotatedTarget "anti-inflammatory agents" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500211 ; owl:annotatedTarget "Any deviation from the normal concentration of threonine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500211 ; owl:annotatedTarget "Abnormal threonine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67079 ; owl:annotatedTarget "antiinflammatory agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67079 ; owl:annotatedTarget "antiinflammatory agents" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500212 ; owl:annotatedTarget "Abnormally increased levels of threonine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500212 ; owl:annotatedTarget "High threonine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "base analog" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500213 ; owl:annotatedTarget "Abnormally decreased levels of threonine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500213 ; owl:annotatedTarget "Low threonine levels in the cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "base analogs" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500214 ; owl:annotatedTarget "Any deviation from the normal concentration of aromatic amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500214 ; owl:annotatedTarget "Abnormal aromatic amino acid levels in cerebrospinal fluid" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "Beilstein:1901205" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "base analogue" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500215 ; owl:annotatedTarget "Any deviation from the normal concentration of phenylalanine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "base analogues" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500215 ; owl:annotatedTarget "Abnormal phenylalanine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500217 ; owl:annotatedTarget "Abnormally increased levels of aspartic acid in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500217 ; owl:annotatedTarget "High aspartic acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500217 ; owl:annotatedTarget "Increased CSF aspartic acid concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "nucleobase analog" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500218 ; owl:annotatedTarget "Any deviation from the normal concentration of tryptophan in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "nucleobase analogs" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500219 ; owl:annotatedTarget "Any deviation from the normal concentration of tyrosine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500219 ; owl:annotatedTarget "Abnormal tyrosine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67142 ; owl:annotatedTarget "nucleobase analogues" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_67200 ; owl:annotatedTarget "provitamin As" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500220 ; owl:annotatedTarget "Abnormally increased levels of tyrosine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500220 ; owl:annotatedTarget "High tyrosine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68452 ; owl:annotatedTarget "azoles" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500221 ; owl:annotatedTarget "Abnormally decreased levels of tyrosine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500221 ; owl:annotatedTarget "Low tyrosine levels in the cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500222 ; owl:annotatedTarget "Abnormally increased levels of tryptophan in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500222 ; owl:annotatedTarget "High tryptophan levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "PMID:19443021" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500223 ; owl:annotatedTarget "Abnormally increased levels of phenylalanine in cerebrospinal fluid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "PMID:25568069" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500223 ; owl:annotatedTarget "High phenylalanine levels in cerebrospinal fluid" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "CAS:71-47-6" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "PMID:31537530" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500224 ; owl:annotatedTarget "Abnormally decreased levels of phenylalanine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500224 ; owl:annotatedTarget "Low phenylalanine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500225 ; owl:annotatedTarget "Any deviation from the normal concentration of serine-family amino acids in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500225 ; owl:annotatedTarget "Abnormal serine-family amino acid levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "Gala1-4Galb1-4Glcb" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500226 ; owl:annotatedTarget "Any deviation from the normal concentration of serine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500226 ; owl:annotatedTarget "Abnormal serine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "Galalpha1-4Galbeta1-4Glcbeta" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "O-alpha-D-galactopyranosyl-(1->4)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500227 ; owl:annotatedTarget "Abnormally increased levels of serine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500227 ; owl:annotatedTarget "High serine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500228 ; owl:annotatedTarget "Abnormally decreased levels of serine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500228 ; owl:annotatedTarget "Low serine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500229 ; owl:annotatedTarget "Any deviation from the normal concentration of glycine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68485 ; owl:annotatedTarget "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500230 ; owl:annotatedTarget "Abnormally increased levels of glycine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500230 ; owl:annotatedTarget "High glycine levels in cerebrospinal fluid" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "CAS:71-47-6" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "CAS:626-51-7" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500232 ; owl:annotatedTarget "Any deviation from the normal concentration of alanine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500232 ; owl:annotatedTarget "Abnormal alanine levels in cerebrospinal fluid" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170117" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500233 ; owl:annotatedTarget "Abnormally increased levels of alanine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500233 ; owl:annotatedTarget "High alanine levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500234 ; owl:annotatedTarget "Abnormally decreased levels of alanine in cerebrospinal fluid." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "Reaxys:1759502" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500234 ; owl:annotatedTarget "Low alanine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "3-methylpentanedioic acid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500235 ; owl:annotatedTarget "Any deviation from the normal concentration of histidine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500235 ; owl:annotatedTarget "Abnormal histidine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68566 ; owl:annotatedTarget "beta-methylglutaric acid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500236 ; owl:annotatedTarget "Abnormally increased levels of histidine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500236 ; owl:annotatedTarget "High histidine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500237 ; owl:annotatedTarget "Abnormally decreased levels of histidine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:715764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500237 ; owl:annotatedTarget "Low histidine levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:27067000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500238 ; owl:annotatedTarget "Any deviation from the normal concentration of albumin in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:27067000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500238 ; owl:annotatedTarget "Abnormal albumin levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:27067000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500239 ; owl:annotatedTarget "High albumin levels in cerebrospinal fluid" . [] oboInOwl:hasDbXref "PMID:27067000" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0500239 ; owl:annotatedTarget "Abnormally increased levels of albumin in cerebrospinal fluid." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "Gmelin:1006" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "CAS:486-56-6" . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500240 ; owl:annotatedTarget "Any deviation from the normal concentration of carnosine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500240 ; owl:annotatedTarget "Abnormal carnosine levels in cerebrospinal fluid" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "Drug_Central:737" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:14700346" . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500241 ; owl:annotatedTarget "Any deviation from the normal concentration of homocarnosine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500241 ; owl:annotatedTarget "Abnormal homocarnosine levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:21655912" . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500242 ; owl:annotatedTarget "Abnormally increased levels of homocarnosine in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:16341596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500242 ; owl:annotatedTarget "High homocarnosine levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:21953524" . [] oboInOwl:hasDbXref "PMID:20551690" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500243 ; owl:annotatedTarget "Any deviation from the normal concentration of ornithine in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:20551690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500243 ; owl:annotatedTarget "Abnormal ornithine levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22027507" . [] oboInOwl:hasDbXref "PMID:20551690" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500244 ; owl:annotatedTarget "Abnormally increased levels of ornithine in cerebrospinal fluid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22137886" . [] oboInOwl:hasDbXref "PMID:20551690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500244 ; owl:annotatedTarget "High ornithine levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22169225" . [] oboInOwl:hasDbXref "PMID:16793028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500245 ; owl:annotatedTarget "Any deviation from the normal concentration of citrulline in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:16793028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500245 ; owl:annotatedTarget "Abnormal citrulline levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22180597" . [] oboInOwl:hasDbXref "PMID:16793028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500246 ; owl:annotatedTarget "Abnormally increased levels of citrulline in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:16793028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500246 ; owl:annotatedTarget "High citrulline levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22200307" . [] oboInOwl:hasDbXref "PMID:3397910" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500247 ; owl:annotatedTarget "Any deviation from the normal concentration of alpha-aminobutyrate in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:3397910" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500247 ; owl:annotatedTarget "Abnormal alpha-aminobutyrate levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22244928" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22253001" . [] oboInOwl:hasDbXref "PMID:3397910" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500248 ; owl:annotatedTarget "Concentration of alpha-aminobutyrate in the cerebrospinal fluid above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:3397910" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500248 ; owl:annotatedTarget "High alpha-aminobutyrate levels in cerebrospinal fluid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22434216" . [] oboInOwl:hasDbXref "PMID:28785375" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500249 ; owl:annotatedTarget "Any deviation from the normal concentration of ethanolamine in circulation." . [] oboInOwl:hasDbXref "PMID:28785375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500249 ; owl:annotatedTarget "Abnormal ethanolamine levels in the blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22460317" . [] oboInOwl:hasDbXref "PMID:28785375" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500250 ; owl:annotatedTarget "Abnormally increased levels of ethanolamine in circulation." . [] oboInOwl:hasDbXref "PMID:28785375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500250 ; owl:annotatedTarget "High ethanolamine levels in the blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22487419" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22489581" . [] oboInOwl:hasDbXref "PMID:25051233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500251 ; owl:annotatedTarget "Abnormal concentration of sebacic acid in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22574797" . [] oboInOwl:hasDbXref "PMID:25051233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500252 ; owl:annotatedTarget "Elevated concentration of sebacic acid in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22608097" . [] oboInOwl:hasDbXref "PMID:11121859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500253 ; owl:annotatedTarget "Elevated concentration of gamma-aminobutyric acid in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22678157" . [] oboInOwl:hasDbXref "PMID:2775902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500254 ; owl:annotatedTarget "Abnormal concentration of hexanoylglycine in the urine." . [] oboInOwl:hasDbXref "PMID:2775902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500254 ; owl:annotatedTarget "Abnormal urinary N-hexanoylglycine levels" . [] oboInOwl:hasDbXref "PMID:2775902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500255 ; owl:annotatedTarget "Elevated concentration of hexanoylglycine in the urine." . [] oboInOwl:hasDbXref "PMID:2775902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500255 ; owl:annotatedTarget "Elevated urinary N-hexanoylglycine concentration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22687995" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "PMID:3946945" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "PMID:28053874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500256 ; owl:annotatedTarget "Abnormal concentration of isobutyrylglycine in the urine." . [] oboInOwl:hasDbXref "PMID:28053874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500256 ; owl:annotatedTarget "Abnormal urinary isobutyrylglycine levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22809871" . [] oboInOwl:hasDbXref "PMID:28053874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500257 ; owl:annotatedTarget "Elevated concentration of isobutyrylglycine in the urine." . [] oboInOwl:hasDbXref "PMID:28053874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500257 ; owl:annotatedTarget "High urinary isobutyrylglycine levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22871902" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500258 ; owl:annotatedTarget "Abnormal CO2 level in cord blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22878732" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500259 ; owl:annotatedTarget "Abnormal O2 level in cord blood" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22899265" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500261 ; owl:annotatedTarget "Anaesthetics trigger episodes" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500261 ; owl:annotatedTarget "Anaesthetics triggered symptoms" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0500261 ; owl:annotatedTarget "Triggered by anaesthetics" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:22919158" . [] oboInOwl:hasDbXref "PMID:14676077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500262 ; owl:annotatedTarget "The most dramatic and severe form of hair loss characterized by an absence of hair follicles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:23000417" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500263 ; owl:annotatedTarget "Abnormal proportion of helper T cells relative to the total number of T cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:23011941" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500264 ; owl:annotatedTarget "Increased proportion of helper T cells relative to the total number of T cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "PMID:23087643" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "Reaxys:5736575" . [] oboInOwl:hasDbXref "PMID:15838378" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500265 ; owl:annotatedTarget "An increased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "Reaxys:1901205" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "Reaxys:83099" . [] oboInOwl:hasDbXref "PMID:15838378" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500266 ; owl:annotatedTarget "An decreased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "(5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "(S)-(-)-Cotinine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500269 ; owl:annotatedTarget "Abnormal proportion of gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500270 ; owl:annotatedTarget "Increased proportion of gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "(S)-Cotinine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500271 ; owl:annotatedTarget "Decreased proportion of gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500272 ; owl:annotatedTarget "Abnormal proportion of immature gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "cotinina" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "cotinine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500273 ; owl:annotatedTarget "Increased proportion of immature gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "cotinine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0500274 ; owl:annotatedTarget "Decreased proportion of immature gamma-delta T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:3954464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0550003 ; owl:annotatedTarget "Symmetrical thickening, tightening and induration of the skin of the fingers and the skin proximal to the metacarpophalangeal or metatarsophalangeal joints. These changes can involve the entire limb, face, neck and trunk." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ucbasharo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0550004 ; owl:annotatedTarget "Slightly raised wart 2-5 mm in diameter often associated with viral infections, commonly persistent in immunodeficient individuals." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_68641 ; owl:annotatedTarget "cotininum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0550004 ; owl:annotatedTarget "Flat wart" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:7378088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0550005 ; owl:annotatedTarget "It is a bilateral reticular pattern of linear or lineonodular densities that are most pronounced in basilar portions of the lungs on standard chest x-ray. It is the third minor criterion for scleroderma diagnosis." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_7044 ; owl:annotatedTarget "Myoglobin" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "UM-BBD_compID:c0106" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7044 ; owl:annotatedTarget "vertebrate myoglobin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70709 ; owl:annotatedTarget "PR agonist" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70709 ; owl:annotatedTarget "PR agonists" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70709 ; owl:annotatedTarget "progesterone receptor agonists" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70958 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000013 ; owl:annotatedTarget "An abnormality of the platysma muscle." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70958 ; owl:annotatedTarget "Reaxys:611190" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70958 ; owl:annotatedTarget "1-methylhistidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000016 ; owl:annotatedTarget "An abnormality of the styloglossus muscle." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70958 ; owl:annotatedTarget "2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "formate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70958 ; owl:annotatedTarget "1-methyl-DL-histidine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000019 ; owl:annotatedTarget "Abnormality of cheek mucosa" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000019 ; owl:annotatedTarget "Abnormality of inside lining of cheek" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "PMID:24009031" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000023 ; owl:annotatedTarget "An abnormality of the angular artery, the terminal branch of the facial artery." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "PMID:24681531" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000024 ; owl:annotatedTarget "Any structural abnormality of a facial artery, one of the branches of the external carotid artery." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "Reaxys:83652" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "3-methylhistidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000030 ; owl:annotatedTarget "Abnormality of bones of the orbit of the skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000030 ; owl:annotatedTarget "Abnormality of the bony eye socket" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000030 ; owl:annotatedTarget "Abnormality of the orbital bones of skull" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70959 ; owl:annotatedTarget "3-methyl-DL-histidine" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "formate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000033 ; owl:annotatedTarget "Abnormality of adenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000033 ; owl:annotatedTarget "Abnormality of nasopharyngeal tonsil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000033 ; owl:annotatedTarget "Abnormality of pharyngeal tonsil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_3000033 ; owl:annotatedTarget "The adenoid, a mass of lymphatic tissue situated posterior to the nasal cavity, in the roof of the nasopharynx, where the nose blends into the throat." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:14723814" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000034 ; owl:annotatedTarget "Abnormality of cartilage of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000034 ; owl:annotatedTarget "Abnormality of cartilage of septum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000034 ; owl:annotatedTarget "Anomaly of cartilage of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_3000034 ; owl:annotatedTarget "Deformity of cartilage of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_3000034 ; owl:annotatedTarget "Malformation of cartilage of nasal septum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:17712735" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000035 ; owl:annotatedTarget "Abnormality of the plexus of the ventral rami of the first four cervical spinal nerves which are located from C1 to C4 cervical segment in the neck." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:20528888" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000036 ; owl:annotatedTarget "An abnormality of a blood vessel of the head, including branches of the arterial and venous systems of the head." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000036 ; owl:annotatedTarget "Abnormality of blood vessel of head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000036 ; owl:annotatedTarget "Abnormality of head blood vessel" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:20836999" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000037 ; owl:annotatedTarget "An abnormality of a blood vessel of the neck, including branches of the arterial and venous systems of the neck." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000037 ; owl:annotatedTarget "Abnormality of blood vessel of neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000037 ; owl:annotatedTarget "Abnormality of neck blood vessel" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:23062437" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:7360517" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_3000041 ; owl:annotatedTarget "Abnormality of carotid artery" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_3000041 ; owl:annotatedTarget "Disorder of carotid artery" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:7408214" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000042 ; owl:annotatedTarget "Abnormality of jugular vein" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000043 ; owl:annotatedTarget "Abnormal vein of face" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "HCO2 anion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "PMID:8548022" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000043 ; owl:annotatedTarget "Abnormality of facial vein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000044 ; owl:annotatedTarget "An abnormality of a frontal process of the maxilla bone." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "Reaxys:1762789" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "N-(2-methylpropanoyl)glycine" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "[(2-methylpropanoyl)amino]acetic acid" . [] oboInOwl:hasDbXref "PMID:26504711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000048 ; owl:annotatedTarget "Any structural anomaly of a great auricular nerve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "N-isobutanoylglycine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "isobutanoylglycine" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_70979 ; owl:annotatedTarget "isobutyrylglycine" . [] oboInOwl:hasDbXref "PMID:30969548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000052 ; owl:annotatedTarget "Any structural abnormality of the hyoid bone (hyoid), a small U-shaped (horseshoe-shaped) solitary bone, situated in the midline of the neck anteriorly at the base of the mandible and posteriorly at the fourth cervical vertebra." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "EC 2 inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000053 ; owl:annotatedTarget "A structural anomaly of the hypopharyx, which is the most inferior portion of the pharynx. The hypopharynx continues from the oropharynx at the pharyngoepiglottic fold superiorly and extends inferiorly to the level of the inferior aspect of the cricoid cartilage, which marks the beginning of the cervical esophagus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000053 ; owl:annotatedTarget "Abnormality of hypopharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000053 ; owl:annotatedTarget "Abnormality of lower pharynx" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "EC 2 inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "EC 2.* (transferase) inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "aminate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "EC 2.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "EC 2.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "transferase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71300 ; owl:annotatedTarget "transferase inhibitors" . [] oboInOwl:hasDbXref "PMID:26564432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000061 ; owl:annotatedTarget "A structural abnormality of an infra-orbital nerve. The infraorbital nerve arises from the maxillary branch of the trigeminal nerve and normally traverses the orbital floor in the infraorbital canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_3000064 ; owl:annotatedTarget "Abnormality of intrinsic lingual muscle" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_71406 ; owl:annotatedTarget "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-N-methylethanaminium" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71406 ; owl:annotatedTarget "(R)-adrenaline" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71406 ; owl:annotatedTarget "(R)-adrenaline cation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71406 ; owl:annotatedTarget "L-epinephrine cation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "formiate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71406 ; owl:annotatedTarget "L-epinephrine(1+)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71666 ; owl:annotatedTarget "gamma-amino acid anions" . [] oboInOwl:hasDbXref "PMID:27662622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_3000075 ; owl:annotatedTarget "Any structural anomaly of a lingual nerve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_71671 ; owl:annotatedTarget "aldonates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72695 ; owl:annotatedTarget "organic compound" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72695 ; owl:annotatedTarget "organic compounds" . [] oboInOwl:hasDbXref "PMID:18581348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000003 ; owl:annotatedTarget "Increased duration of myocardial T2 time without gadolinium contrast. Elevated T2, which can detect myocardial edema." . [] oboInOwl:hasDbXref "PMID:20704762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000004 ; owl:annotatedTarget "Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium." . [] oboInOwl:hasDbXref "PMID:21969014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000005 ; owl:annotatedTarget "Areas of high signal intensity in magnetic resonance imaging of the pericardium appearing around 10 minutes after injection of the intercellular contrast agent gadolinium." . [] oboInOwl:hasDbXref "PMID:24617686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000006 ; owl:annotatedTarget "Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity." . [] oboInOwl:hasDbXref "PMID:26694039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000007 ; owl:annotatedTarget "Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath." . [] oboInOwl:hasDbXref "PMID:26550358", "PMID:31704776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000008 ; owl:annotatedTarget "Pronuclei formation is a critical process during fertilisation. Normally, there are two pronuclei (2PN), including the paternal pronucleus and the maternal pronucleus, in the zygote after fertilisation. It is generally accepted that multiple pronuclei (MPN) formation is due to the abnormal extrusion of the second polar body or to abnormal fertilisation with multiple sperm. The MPN therefore can cause infertility and recurrent failure of IVF/ICSI." . [] oboInOwl:hasDbXref "PMID:29666064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000009 ; owl:annotatedTarget "An excessive, irrational and debilitating fear to carry out a physical movement, due to a feeling of vulnerability to a painful injury or reinjury." . [] oboInOwl:hasDbXref , "PMID:31474092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000010 ; owl:annotatedTarget "Decreased renal tubular reabsorption of bicarbonate." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72695 ; owl:annotatedTarget "organic molecules" . [] oboInOwl:hasDbXref "PMID:20300545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000011 ; owl:annotatedTarget "A congenital human papillomavirus (HPV) infection of the newborn. Congential HPV infection can manifest as condyloma cuminata in the newborn." . [] oboInOwl:hasDbXref "PMID:24275244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000015 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against envoplakin, a cytoskeletal linker protein that links intermediate filaments to cellular junctions." . [] oboInOwl:hasDbXref "PMID:24275244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000016 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against periplakin." . [] oboInOwl:hasDbXref "PMID:32048350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000019 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against BP230." . [] oboInOwl:hasDbXref "PMID:32048350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000020 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against BP180." . [] oboInOwl:hasDbXref "PMID:21725315", "PMID:24154702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000021 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-332." . [] oboInOwl:hasDbXref "PMID:24154702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000023 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against laminin gamma-1." . [] oboInOwl:hasDbXref "PMID:33483531" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000025 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against an integrin. Integrins are a family of cell adhesion molecules with 24 known integrin heterodimers. Integrins transduce mechanical and biochemical signals from fibrotic extracellular matrix into the cell, activate latent TGFbeta, and subsequently modulate fibroblast adhesion, migration, and growth." . [] oboInOwl:hasDbXref "PMID:11180014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000028 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against LABD97, which is structurally identical to a portion of the extracellular domain of BPAg2. BPAg2, a 180 kDa bullous pemphigoid antigen, is a transmembrane protein important for basement membrane cohesion." . [] oboInOwl:hasDbXref "PMID:24052912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000029 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against gliadin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:11160795" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000029 ; owl:annotatedTarget "AGA autoantibodies" . [] oboInOwl:hasDbXref "PMID:23365209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000030 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against reticulin." . [] oboInOwl:hasDbXref "PMID:29619029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000031 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against collagen type VII." . [] oboInOwl:hasDbXref "PMID:29443215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000032 ; owl:annotatedTarget "A perception that one's body is moving or swaying despite lack of motion of the body." . [] oboInOwl:hasDbXref "PMID:27083889", "PMID:32986636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000033 ; owl:annotatedTarget "A perception of unsteadiness of dizziness that is not characterized bythe spinning sensation of classic vertigo, but rather by an oscillatory perception (rocking, bobbing, or swaying despite the fact that the subject is not moving)." . [] oboInOwl:hasDbXref "PMID:32569607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000034 ; owl:annotatedTarget "Decreased lymphocyte count during infections." . [] oboInOwl:hasDbXref "PMID:23533926" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000035 ; owl:annotatedTarget "Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction." . [] oboInOwl:hasDbXref "PMID:32644551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000036 ; owl:annotatedTarget "A type of hydrocele testis in which both the proximal and distal portions of processus vaginalis get obliterated while the central portion remains patent and fluid accumulates within it." . [] oboInOwl:hasDbXref "PMID:32644551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000037 ; owl:annotatedTarget "Congenital hydrocele occurs when processus vaginalis is patent and communicates with the peritoneal cavity. This communication allows the movement of peritoneal fluid but is too small to allow the intra-abdominal contents to herniate through." . [] oboInOwl:hasDbXref "PMID:32644551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000038 ; owl:annotatedTarget "Infantile Hydrocele is a type pf hydrocele in which the processus vaginalis gets obliterated at the level of the deep inguinal ring. However, the portion distal to it remains patent and allows fluid accumulation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:11785425" . [] oboInOwl:hasDbXref "PMID:32161190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000039 ; owl:annotatedTarget "A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count." . [] oboInOwl:hasDbXref , "PMID:29261990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000041 ; owl:annotatedTarget "Extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein, a hepatic acute phase reactant." . [] oboInOwl:hasDbXref "PMID:9897960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000055 ; owl:annotatedTarget "A reaction characterizeds by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling localized to the in the intestinal tract." . [] oboInOwl:hasDbXref "PMID:11420279" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000056 ; owl:annotatedTarget "Any abnormality of programmed cell death (apoptosis), which is defined as the orchestrated collapse of a cell characterised by membrane blebbing, cell shrinkage, condensation of chromatin, and fragmentation of DNA followed by rapid engulfment of the corpse by neighbouring cells. Apoptosis is distinguished from death by necrosis by the absence of an associated inflammatory response." . [] oboInOwl:hasDbXref "PMID:29617412" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000057 ; owl:annotatedTarget "A reduced amount of programmed cell death upon stimulation of the FAS receptor, which normally induces caspase-8 dependent apoptosis." . [] oboInOwl:hasDbXref "PMID:24285676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000061 ; owl:annotatedTarget "A diffuse and specific increase in the number of alpha-cells." . [] oboInOwl:hasDbXref , "PMID:27698627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000062 ; owl:annotatedTarget "A congenital hand malformation characterized by the coalescence of the coalescence of third and fourth metacarpals (i.e., those corresponding to the middle and ring fingers)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "formic acid, ion(1-)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:1444258" . [] oboInOwl:hasDbXref "PMID:9685125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000067 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the iliac artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000068 ; owl:annotatedTarget "Any deviation from normal intensity or subject of a person's interests, which can be defined as a state of giving selective attention to something." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000069 ; owl:annotatedTarget "Fixated interest in unusual objects" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000069 ; owl:annotatedTarget "Fixated interest with parts of objects" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000069 ; owl:annotatedTarget "Fixation with parts of objects" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000070 ; owl:annotatedTarget "Circumscribed interests" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:15738217" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000070 ; owl:annotatedTarget "Restricted interests" . [] oboInOwl:hasDbXref "PMID:26803417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000075 ; owl:annotatedTarget "The number of times facial expressions are produced in a given period is lower than expected given the social and cultural context." . [] oboInOwl:hasDbXref "PMID:25388062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000076 ; owl:annotatedTarget "Moving another person's hand, body part, or body to communicate a desire, e.g. pushing or pulling someone toward a desired object or placing someone's hand on something." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000076 ; owl:annotatedTarget "Hand-leading gesture" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000076 ; owl:annotatedTarget "Hand-taking gestures" . [] oboInOwl:hasDbXref "PMID:23880382" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000078 ; owl:annotatedTarget "An abnormally intense interest in a topic or object that is not atypical for the social context of the affected person." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000079 ; owl:annotatedTarget "Unusual interest in sensory aspects of the environment." . [] oboInOwl:hasDbXref "PMID:21182208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000081 ; owl:annotatedTarget "Diminished use of typical non-verbal conversational gestures such as shaking the head to indicate no or nodding the head to indicate yes." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000087 ; owl:annotatedTarget "Abnormal facial expression use" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000089 ; owl:annotatedTarget "Atypical facial expressions" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:16075348" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000090 ; owl:annotatedTarget "Abnormal communicative gesture use" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000090 ; owl:annotatedTarget "Abnormal communicative gestures" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000090 ; owl:annotatedTarget "Abnormal gestures" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000092 ; owl:annotatedTarget "Failure of normal back-and-forth conversation" . [] oboInOwl:hasDbXref "PMID:22114445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000093 ; owl:annotatedTarget "A condition in which the permanent teeth, because of deficiency of growth in the jaw or segment of jaw, assume a path of eruption that intercepts a primary tooth, causes its premature loss and produces a consequent malposition of the permanent tooth." . [] oboInOwl:hasDbXref "PMID:21220346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000094 ; owl:annotatedTarget "A developmental anomaly characterized by undergrowth of the corpus cavernosum." . [] oboInOwl:hasDbXref "PMID:33916495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000095 ; owl:annotatedTarget "Concentration of the nucleobase thymine in the blood circulation above the normal range." . [] oboInOwl:hasDbXref "PMID:18985811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000100 ; owl:annotatedTarget "Elevated hydrogen gas level in exhaled breath following oral administration of lactose. In individuals with lactose intolerance, undigested lactose in the colon will be metabolized by colonic bacteria, releasing hydrogen gas." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:17440912" . [] oboInOwl:hasDbXref "PMID:7932993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000105 ; owl:annotatedTarget "The four-chamber (4Ch) view of the fetal heart is the most widely used screening examination for the detection of structural cardiac abnormalities during routine fetal ultrasonography. In the healthy normal fetus, the apical 4Ch view demonstrates four well-developed chambers, a concordant atrioventricular (AV) connection, unobstructed AV valves (mitral and tricuspid valves), the foramen ovale flap opening into left atrium (LA), and an intact interventricular septum. Additionally, the pulmonary venous opening can be visualized at the LA wall. Any structural deviations from normal anatomy may lead to congenital heart disease that can be determined by the 4Ch view of the fetal heart's ultrasound imaging." . [] oboInOwl:hasDbXref "PMID:21339940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000107 ; owl:annotatedTarget "Deposits of immunoglobulins and complement components along the dermoepidermal junction." . [] oboInOwl:hasDbXref "PMID:29716882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000108 ; owl:annotatedTarget "Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of erythroid precursors in the bone marrow." . [] oboInOwl:hasDbXref "PMID:28706902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000111 ; owl:annotatedTarget "History of exposure to asbestos, a fibrous mineral with physical and chemical properties that make it resistant to heat and degradation." . [] oboInOwl:hasDbXref "PMID:16129874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000112 ; owl:annotatedTarget "Information about current or past medications taken by an individual." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:18097339" . [] oboInOwl:hasDbXref "PMID:10193594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000123 ; owl:annotatedTarget "A part of the past medical history consisting of information about the typical food intake of an individual." . [] oboInOwl:hasDbXref "PMID:32887293" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000124 ; owl:annotatedTarget "A history of ingestion of a relatively high amount of foods containing high levels of oxalate, such as green-leaf vegetables, tea, nuts, chocolate and rhubarb." . [] oboInOwl:hasDbXref "PMID:26912510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000128 ; owl:annotatedTarget "Addiction to inhaled nitrous oxide gas (N2O)." . [] oboInOwl:hasDbXref "PMID:31536236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000134 ; owl:annotatedTarget "History of having been treateed with prostaglandin E1." . [] oboInOwl:hasDbXref "PMID:26123886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000138 ; owl:annotatedTarget "The cavum septum pellucidum (CSP) is an important fetal midline forebrain landmark that is normally visible by prenatal sonography. This term refers to the lack of visiblity of the CSP on prenatal sonography. The CSP normally can be visualized between 18 and 37 weeks of gestation. Lack of visualization of the CSP in this time period generally requires follow up and may indicate the presence of underlying malformations such as malformations of the corpus callosum. The lack of CSP before 18 weeks or after 37 weeks of gestation (or postnatally) is considered a normal finding." . [] oboInOwl:hasDbXref "PMID:12780436", "PMID:30763268", "PMID:34189111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000139 ; owl:annotatedTarget "Fetal abdominal cysts are usually detected during the second trimester anomaly scan or discovered incidentally at later gestations. However, a definitive diagnosis is often not made until postnatal life. The most common etiologies of fetal abdominal cysts are: ovarian, gastrointestinal cystic duplication, liver and choledochal, meconium pseudocysts, mesenteric and adrenal. Following identification of a cyst, careful morphological assessment allows the prediction of their natural history and importantly, the likelihood of surgical intervention being required postnatally." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000139 ; owl:annotatedTarget "Foetal abdominal cyst" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000139 ; owl:annotatedTarget "Foetal cystic abdominal mass" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000140 ; owl:annotatedTarget "Foetal bowel dilatation" . [] oboInOwl:hasDbXref "PMID:25250065", "PMID:26498670", "PMID:30363185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000142 ; owl:annotatedTarget "A fetal ultrasound finding defined by flattening of the occiput with pointing of the frontal bones and brachycephaly with an increased cephalic index. It is characterized by keel shaped deformity of forehead with midline ridge, bilateral fronto temporal constriction with compensatory biparietal expansion, supra orbital and lateral orbital retrusion and hypotelorism. This finding is said to resemble a strawberry." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:19453747" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000142 ; owl:annotatedTarget "Foetal trigonocephaly" . [] oboInOwl:hasDbXref "PMID:3317224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000149 ; owl:annotatedTarget "Areas of necrotic tissue within a lymph node." . [] oboInOwl:hasDbXref "PMID:32809572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000153 ; owl:annotatedTarget "A benign tumor arising from the epithelial surface of the cervix and usually caused by Human Papillomavirus infection." . [] oboInOwl:hasDbXref "PMID:33139985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000154 ; owl:annotatedTarget "A benign smooth muscle neoplasm that arises in the liver." . [] oboInOwl:hasDbXref "PMID:21296660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000162 ; owl:annotatedTarget "Decreased activity of the enzyme succinyl-CoA 3-ketoacid CoA transferase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000162 ; owl:annotatedTarget "SCOT activity low in fibroblasts" . [] oboInOwl:hasDbXref "PMID:10767344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000163 ; owl:annotatedTarget "Reduced activity of the enzyme phytanoyl-CoA hydroxylase, which plays a role in the catabolism of phytanic acid, a branched-chain fatty acid that is a normal constituent of the human diet." . [] oboInOwl:hasDbXref "PMID:32904102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000164 ; owl:annotatedTarget "Diminished activity of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4), also known as D-bifunctional protein (DBP), a peroxisomal enzyme that catalyzes multiple steps of beta-oxidation of very long chain fatty acids." . [] oboInOwl:hasDbXref "PMID:30974122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000165 ; owl:annotatedTarget "Reduced plasmalogen concentration in the blood circulation." . [] oboInOwl:hasDbXref "PMID:31527188" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000166 ; owl:annotatedTarget "Infection with live, attenuated varicella-zoster virus following vaccination. This is an extreemely rare event that may indicate immunocompromise." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:20172021" . [] oboInOwl:hasDbXref "PMID:23497566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000169 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the pons." . [] oboInOwl:hasDbXref "PMID:20816272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000171 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against a voltage-gated potassium channel." . [] oboInOwl:hasDbXref "PMID:36454551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_4000178 ; owl:annotatedTarget "History of having been treated with an antiretroviral agent." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_4000181 ; owl:annotatedTarget "Excessive wear and tear on teeth" . [] oboInOwl:hasDbXref "PMID:28062719", "PMID:33843981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000000 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-adenylate kinase 5 (AK5)." . [] oboInOwl:hasDbXref "PMID:25979696", "PMID:29225271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000001 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)." . [] oboInOwl:hasDbXref "PMID:20420178", "PMID:27773907", "PMID:31624089", "PMID:32087460", "PMID:33173498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000002 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Amphiphysin." . [] oboInOwl:hasDbXref "PMID:26298328", "PMID:28601293", "PMID:30158896" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000003 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Rho GTPase-activating protein 26 (ARHGAP26)." . [] oboInOwl:hasDbXref "PMID:23568983", "PMID:26377085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000004 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Carbonic anhydrase-related protein VIII (CARPVIII)." . [] oboInOwl:hasDbXref "PMID:29561731", "PMID:32651251", "PMID:32783406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000005 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against contactin-associated protein-like 2 (CASPR2)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:20631870" . [] oboInOwl:hasDbXref "PMID:18931014", "PMID:31656691", "PMID:32110228" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000006 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CV2/CRMP5. Anti-CV2/CRMP5 autoantibody is the most commonly detected anti-neuronal autoantibody. Patients with typical paraneoplastic chorea show fully developed chorea in the course of weeks to months with acute inflammation in the striatum." . [] oboInOwl:hasDbXref "PMID:27299786", "PMID:28258082", "PMID:32087460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000007 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dipeptidyl-peptidase-like protein 6 (DPPX)." . [] oboInOwl:hasDbXref "PMID:33563795", "PMID:33588772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000008 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against FGFR3." . [] oboInOwl:hasDbXref "PMID:28202703", "PMID:30347219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000009 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid A receptor, i.e., GABA(A)R." . [] oboInOwl:hasDbXref "PMID:32103919", "PMID:32710704", "PMID:32783406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000010 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid B receptor, i.e., GABA(B)R." . [] oboInOwl:hasDbXref "PMID:30343467", "PMID:32087461", "PMID:32123047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000011 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamic acid decarboxylase 65 (GAD65)." . [] oboInOwl:hasDbXref "PMID:20420178", "PMID:22270318", "PMID:29561731" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000012 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Gephyrin." . [] oboInOwl:hasDbXref "PMID:28120349", "PMID:30663514", "PMID:32019875", "PMID:32827972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000013 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glial fibrillary acidic protein (GFAP)." . [] oboInOwl:hasDbXref "PMID:21242500", "PMID:22215239", "PMID:32087460", "PMID:32585946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000014 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Glycine receptor (GlyR)." . [] oboInOwl:hasDbXref "PMID:26377085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000015 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Homer-3." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:20718297" . [] oboInOwl:hasDbXref "PMID:11344832", "PMID:18931014", "PMID:19015226", "PMID:25764259", "PMID:32851899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000016 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Hu." . [] oboInOwl:hasDbXref "PMID:27299786", "PMID:28381508", "PMID:30694925" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000017 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against immunoglobulin-like cell adhesion molecule 5 (IgLON5)." . [] oboInOwl:hasDbXref "PMID:28203616" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000018 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against inositol 1,4,5-trisphosphate receptor 1 (ITPR1)." . [] oboInOwl:hasDbXref "PMID:31269365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000019 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against kelch-like protein 11 (KLHL11)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5000019 ; owl:annotatedTarget "Anti-KLHL11 antibody" . [] oboInOwl:hasDbXref "PMID:32710704", "PMID:32783406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000020 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against leucine-rich glioma-inactivated 1 (LGI1)." . [] oboInOwl:hasDbXref "PMID:27460184", "PMID:33070888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000021 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma." . [] oboInOwl:hasDbXref "PMID:15179063", "PMID:15215214", "PMID:18223018", "PMID:26664526", "PMID:27460184", "PMID:31044049", "PMID:31454760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000022 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma2." . [] oboInOwl:hasDbXref "PMID:15179063", "PMID:27460184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000023 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma1." . [] oboInOwl:hasDbXref "PMID:26377085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000024 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 1 (mGluR1)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:2688547" . [] oboInOwl:hasDbXref "PMID:29703767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000025 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 5 (mGluR5)." . [] oboInOwl:hasDbXref "PMID:27170572", "PMID:27170573", "PMID:28840178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000026 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neurexin-3alpha." . [] oboInOwl:hasDbXref "PMID:18295972", "PMID:18653248", "PMID:21115345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000027 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against P/Q-type voltage-gated calcium channels (VGCCs)." . [] oboInOwl:hasDbXref "PMID:28074593", "PMID:31801846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000028 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against microtubule-associated protein 1B (MAP1B)." . [] oboInOwl:hasDbXref "PMID:16801349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000029 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against protein kinase Cgamma." . [] oboInOwl:hasDbXref "PMID:15179063", "PMID:29332416", "PMID:32170042" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000030 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ri, an antineuronal antibody." . [] oboInOwl:hasDbXref "PMID:29998156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000031 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Septin-5." . [] oboInOwl:hasDbXref "PMID:33144342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000032 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against seizure-related 6 homolog like 2 (SEZ6L2)." . [] oboInOwl:hasDbXref "PMID:19667272", "PMID:32103919" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000033 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SOX1. Anti-SOX1 antibodies, also known as antiglial nuclear antibody (AGNA), are specifically found in paraneoplastic neurological disorders. Since SOX1 is expressed in neuronal precursor cells in the developing central nervous system, it has been used as an early marker of neural stem cells." . [] oboInOwl:hasDbXref "PMID:15179063", "PMID:25745634", "PMID:26377319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000034 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Tr/DNER. Anti-Tr antibodies are directed against cerebellar Purkinje cells (termed anti-Tr or PCA-Tr). Anti-Tr autoantibodies are frequently associated with Hodgkin lymphoma (HL). Anti-Tr antibodies are defined by a specific staining pattern in cerebellar tissue that is characterized by punctate immunoreactivity in both the dendritic tree and soma of Purkinje cells but not in their axons. This characteristic pattern is indicative of the presence of anti-Tr antibodies. The Delta/Notch-like epidermal growth factor-related receptor (DNER) was identified as the target antigen of anti-Tr." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "formylate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "PMID:6354590" . [] oboInOwl:hasDbXref "PMID:28904989" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000035 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the axon initial segment protein tripartite motif 46 (TRIM46)." . [] oboInOwl:hasDbXref "PMID:30350014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000036 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against TRIM9/TRIM67." . [] oboInOwl:hasDbXref "PMID:10980743", "PMID:27606347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000037 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Yo." . [] oboInOwl:hasDbXref "PMID:27235344", "PMID:30918333", "PMID:32830177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000038 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against titin." . [] oboInOwl:hasDbXref "PMID:29249374", "PMID:29525731", "PMID:31533147", "PMID:32087460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000039 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Zic family member 4 (ZIC4)." . [] oboInOwl:hasDbXref "PMID:23568983", "PMID:26377085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000042 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Sj/inositol 1,4,5-trisphosphate receptor." . [] oboInOwl:hasDbXref "PMID:27299786", "PMID:32612568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000043 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dopamine-2 receptor." . [] oboInOwl:hasDbXref "PMID:33949707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000044 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamate kainate receptor subunit 2 (GluK2)." . [] oboInOwl:hasDbXref "PMID:32830177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000046 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against low-density lipoprotein receptor (Lrp4)." . [] oboInOwl:hasDbXref "PMID:30918333" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000047 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ryanodine receptor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "exopolysaccharides" . [] oboInOwl:hasDbXref "PMID:22167224", "PMID:30918333" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5000048 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the voltage-gated potassium channel Kv1.4." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200002 ; owl:annotatedTarget "Reduced range of facial expressions" . [] oboInOwl:hasDbXref "PMID:28838622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200009 ; owl:annotatedTarget "Hand stereotypies within the medial plane of the body." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200015 ; owl:annotatedTarget "Flat facial expression" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200021 ; owl:annotatedTarget "Abnormal social understanding" . [] oboInOwl:hasDbXref "PMID:18221343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200026 ; owl:annotatedTarget "A reduced ability to imitate a task or the movements of others." . [] oboInOwl:hasDbXref "PMID:26386541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200044 ; owl:annotatedTarget "Abnormality in one's ability to control their attention toward a specific subject or task. This could include the inability to change attention or hold attention." . [] oboInOwl:hasDbXref "PMID:16263865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200045 ; owl:annotatedTarget "Reduced ability to control, or a failure to resist a temptation, urge, or impulse." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200045 ; owl:annotatedTarget "Impaired self-restraint" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200045 ; owl:annotatedTarget "Impulse control disorders" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "extracellular polymeric substance" . [] oboInOwl:hasDbXref "PMID:22954367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200047 ; owl:annotatedTarget "When one uses gestures that are unique to them and have no apparent meaning to others." . [] oboInOwl:hasDbXref "PMID:31016439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200049 ; owl:annotatedTarget "Atypical focus on arranging, balancing, or positioning objects; may be atypical in focus or intensity." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200049 ; owl:annotatedTarget "Arranging" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200049 ; owl:annotatedTarget "Ordering" . [] oboInOwl:hasDbXref "PMID:31016439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200050 ; owl:annotatedTarget "Checking behavior that is excessive for the situational context." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200050 ; owl:annotatedTarget "Checking behaviors" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200050 ; owl:annotatedTarget "Checking behaviours" . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200058 ; owl:annotatedTarget "A decreased tolerance to sensory stimuli that triggers emotional and/or physical distress." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200059 ; owl:annotatedTarget "Increased tolerance to sensory stimuli due to diminished sensory ability." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200060 ; owl:annotatedTarget "Hyperresponsive to sound that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_72813 ; owl:annotatedTarget "extracellular polymeric substances" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200060 ; owl:annotatedTarget "Loudness intolerance" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200060 ; owl:annotatedTarget "Sensitivity to noise" . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200061 ; owl:annotatedTarget "A decreased tolerance to physical touch." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200062 ; owl:annotatedTarget "Pursuit of specific sounds or noises that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200063 ; owl:annotatedTarget "Pursuit of a particular taste that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200064 ; owl:annotatedTarget "Pursuit of specific scents, smells, or fragrances that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200064 ; owl:annotatedTarget "Smell seeking" . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200065 ; owl:annotatedTarget "Pursuit of a specific texture that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200066 ; owl:annotatedTarget "Pursuit of vestibular stimulation that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200067 ; owl:annotatedTarget "Pursuit visual stimulation by looking at specific sights, images, and/or colors that is abnormal in intensity and/or frequency." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73336 ; owl:annotatedTarget "vulneraries" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_5200069 ; owl:annotatedTarget "Twirling" . [] oboInOwl:hasDbXref "PMID:26263228" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5200105 ; owl:annotatedTarget "Reduced or lack of pretending in play (does not assign abstract properties to objects, use invisible objects, or use objects in nonliteral ways other than their intended purpose in play)." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201000 ; owl:annotatedTarget "Unilateral cleft lip cleft that starts from the bottom of the upper lip but does not reach the nasal cavity." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201001 ; owl:annotatedTarget "Unilateral cleft lip cleft that starts from the bottom of the upper lip and reaches the nasal cavity." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570", "PMID:33729631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201002 ; owl:annotatedTarget "Notch, groove, or scar of the upper lip without noticeable rupture of the lip. Microforms are sometimes associated with disruption of the continuity of the orbicularis oris muscle." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201003 ; owl:annotatedTarget "Cleft hard palate in which the cleft goes through the entire length of the hard palate." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201004 ; owl:annotatedTarget "Cleft hard palate in which the cleft doe not goes through the entire length of the hard palate." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201005 ; owl:annotatedTarget "Cleft soft palate in which the cleft goes through the entire length of the soft palate." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201006 ; owl:annotatedTarget "Cleft soft palate in which the cleft doe not goes through the entire length of the soft palate." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201007 ; owl:annotatedTarget "Cleft maxillary alveolar ridge in which the cleft does not go through the entire length of the maxillary alveolar ridge." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73336 ; owl:annotatedTarget "wound-healing agent" . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201008 ; owl:annotatedTarget "Cleft maxillary alveolar ridge in which the cleft goes through the entire length of the maxillary alveolar ridge." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570", "PMID:33729631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201009 ; owl:annotatedTarget "Cleft of the upper lip that starts from the bottom of the upper lip and reaches the nasal cavity." . [] oboInOwl:hasDbXref "PMID:21331089", "PMID:26171570", "PMID:33729631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201010 ; owl:annotatedTarget "Notch, groove, or scar of the upper lip without noticeable rupture of the lip." . [] oboInOwl:hasDbXref "PMID:19884685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201011 ; owl:annotatedTarget "Bilateral cleft lip in which the cleft lip on both sides is complete, i.e. start from the bottom of the upper lip and reach the nasal cavity." . [] oboInOwl:hasDbXref "PMID:19884685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201012 ; owl:annotatedTarget "Bilateral cleft lip in which the cleft lip on both sides are incomplete (i.e. start from the bottom of the upper lip but do not reach the nasal cavity), or the cleft lip on one is incomplete and a microform on the other side." . [] oboInOwl:hasDbXref "PMID:19884685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201013 ; owl:annotatedTarget "Bilateral cleft lip in which the cleft lip on both sides are microform, i.e. a notch, groove, or scar without noticeable rupture of the lip." . [] oboInOwl:hasDbXref "PMID:19884685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_5201014 ; owl:annotatedTarget "Bilateral cleft lip in which the cleft lip on one side is complete (i.e. starts from the bottom of the upper lip and reaches the nasal cavity), and the one on the other side is incomplete (i.e. starts from the bottom of the upper lip but does not reach the nasal cavity) or microform (i.e. a notch, groove, or scar without noticeable rupture of the lip)." . [] oboInOwl:hasDbXref "UBERON:0000105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000000 ; owl:annotatedTarget "A spatiotemporal region encompassing some part of the life cycle of an organism." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000001 ; owl:annotatedTarget "Temporal interval that defines human life from the prenatal stage until late adulthood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73336 ; owl:annotatedTarget "wound-healing agents" . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000002 ; owl:annotatedTarget "Prenatal stage that starts with fertilization and ends with a fully formed embryo, before undergoing last development during the fetal stage." . [] oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/Gestational_age" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HsapDv_0000002 ; owl:annotatedTarget "first trimester" . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000037 ; owl:annotatedTarget "Prenatal stage that starts with the fully formed embryo and ends at birth." . [] oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/Gestational_age" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HsapDv_0000037 ; owl:annotatedTarget "second and third trimester" . [] oboInOwl:hasDbXref "UBERON:0000068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000045 ; owl:annotatedTarget "Prenatal stage that starts with fertilization and ends at birth." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000080 ; owl:annotatedTarget "Human developmental stage that covers the period from birth until 12 years old." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73336 ; owl:annotatedTarget "wound-healing drug" . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000081 ; owl:annotatedTarget "Immature stage that refers to child who is over 2 and under 13 years old." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000082 ; owl:annotatedTarget "Immature stage that refers to a newborn who is under 32 days old." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000083 ; owl:annotatedTarget "Immature stage that refers to an infant who is over 31 days and is under 24 months old." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000086 ; owl:annotatedTarget "Mature stage that refers to an adolescent who is over 13 and under 19 years old." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73336 ; owl:annotatedTarget "wound-healing drugs" . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000087 ; owl:annotatedTarget "Human developmental stage that refers to an adult who is over 19." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000088 ; owl:annotatedTarget "Adult stage that refers to an adult who is under 45." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000089 ; owl:annotatedTarget "Early adulthood that refers to an adult who is under 25." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000091 ; owl:annotatedTarget "Adult stage that refers to an adult who is over 45." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73541 ; owl:annotatedTarget "organic heterobicyclic rings" . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000092 ; owl:annotatedTarget "Late adulthood that refers to an adult who is over 45 and under 65." . [] oboInOwl:hasDbXref "Bgee:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HsapDv_0000204 ; owl:annotatedTarget "Human developmental stage that refers to a sexually mature human." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_0 ; owl:annotatedTarget "Pathological structure or process" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_1 ; owl:annotatedTarget "The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors." . [] oboInOwl:hasDbXref "UOB:LTS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_1000 ; owl:annotatedTarget "Phenotypic observation of the presence or absence of a pathological entity." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_105 ; owl:annotatedTarget "Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_119 ; owl:annotatedTarget "Abnormal release of whole blood or the cellular component from the circulation." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_120 ; owl:annotatedTarget "A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "hydrogen carboxylate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73558 ; owl:annotatedTarget "D3 vitamin" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_124 ; owl:annotatedTarget "An area of necrosis resulting from a sudden cessation of arterial or venous blood supply." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_126 ; owl:annotatedTarget "Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_14 ; owl:annotatedTarget "A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_149 ; owl:annotatedTarget "Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia)." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_149 ; owl:annotatedTarget "epidermal hyperplasia." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_149 ; owl:annotatedTarget "squamous cell hyperplasia" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_154 ; owl:annotatedTarget "Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_154 ; owl:annotatedTarget "cornification" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_154 ; owl:annotatedTarget "hyperorthokeratosis" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_154 ; owl:annotatedTarget "hyperparakeratosis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_73558 ; owl:annotatedTarget "vitamin D3s" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_156 ; owl:annotatedTarget "Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_175 ; owl:annotatedTarget "The process, normal or abnormal, of damage repair or wound closure." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_176 ; owl:annotatedTarget "Replacement of connective tissue by fibro-fatty deposits and scar tissue." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_184 ; owl:annotatedTarget "Any pathological thickening or hardening of a tissue." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_184 ; owl:annotatedTarget "Induration" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_188 ; owl:annotatedTarget "Inappropriate or aberrant activation or suppression of the immune or inflammatory response." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_194 ; owl:annotatedTarget "Tissue response to inappropriate immune/inflammatory process." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_196 ; owl:annotatedTarget "Inflammation of the skin." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_197 ; owl:annotatedTarget "Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_198 ; owl:annotatedTarget "An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_201 ; owl:annotatedTarget "Inflammation of a blood vessel." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_201 ; owl:annotatedTarget "angiitis" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_201 ; owl:annotatedTarget "arteritis" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_201 ; owl:annotatedTarget "lymphangiitis" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_201 ; owl:annotatedTarget "phlebitis" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_212 ; owl:annotatedTarget "A tissue reaction to an internal or external injury." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_218 ; owl:annotatedTarget "A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_25 ; owl:annotatedTarget "Degenerative process characteristic of a particular tissue." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_254 ; owl:annotatedTarget "Tumors showing multiple histological componants/differentiation." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_267 ; owl:annotatedTarget "Neoplasms derived from glandular epithelial cells." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_27 ; owl:annotatedTarget "Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_27 ; owl:annotatedTarget "Degenerative joint disease" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_27 ; owl:annotatedTarget "osteoarthrosis" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_270 ; owl:annotatedTarget "A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_28 ; owl:annotatedTarget "Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_287 ; owl:annotatedTarget "Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0)." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_287 ; owl:annotatedTarget "Adenoma, endocrine pancreas" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_287 ; owl:annotatedTarget "adenomatosis" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_287 ; owl:annotatedTarget "islet (pancreatic) cell tumor benign" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_309 ; owl:annotatedTarget "Germ cell and non-germ cell tumors of the testis and ovary." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_31 ; owl:annotatedTarget "Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_310 ; owl:annotatedTarget "Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_322 ; owl:annotatedTarget "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1)." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_33 ; owl:annotatedTarget "Accumulation of substances within, on the surface of or between cells." . [] oboInOwl:hasDbXref "URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_335 ; owl:annotatedTarget "Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_34 ; owl:annotatedTarget "Extracellular deposition of amyloid protein." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_34 ; owl:annotatedTarget "Amyloidosis" . [] oboInOwl:hasDbXref "PMID:12070033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_342 ; owl:annotatedTarget "Leukaemias of the myeloid lineage." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_342 ; owl:annotatedTarget "granulocytic leukaemia" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_36 ; owl:annotatedTarget "Intra or extracellular deposition of calcium usually as calcium phosphate." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_379 ; owl:annotatedTarget "Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) ." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_387 ; owl:annotatedTarget "Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0)." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_404 ; owl:annotatedTarget "Neoplasms of the soft and connective tissues." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_429 ; owl:annotatedTarget "Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_474 ; owl:annotatedTarget "Dilation of a tubular structure." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_476 ; owl:annotatedTarget "A lesion formed by a dilated capillary or terminal artery." . [] oboInOwl:hasDbXref "PMID:12070033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_496 ; owl:annotatedTarget "Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition." . [] oboInOwl:hasDbXref "PMID:12070033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_502 ; owl:annotatedTarget "Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts." . [] oboInOwl:hasDbXref "PMID:12070033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_515 ; owl:annotatedTarget "Hematological neoplasias of non-lymphoid origin." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_55 ; owl:annotatedTarget "Developmental and structural abnormalities occurring during embryonic development or during adult life." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "CAS:516-05-2" . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_555 ; owl:annotatedTarget "Deposition of any homogeneous inorganic material." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_556 ; owl:annotatedTarget "Lesions which in some cases have the potential to become progressively growing malignant tumors." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_56 ; owl:annotatedTarget "Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult." . [] oboInOwl:hasDbXref "PMID:8383276" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_574 ; owl:annotatedTarget "Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_579 ; owl:annotatedTarget "Loss of epithelium and the basement membrane (full thickness). Cf Erosion." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_596 ; owl:annotatedTarget "The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_597 ; owl:annotatedTarget "Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_599 ; owl:annotatedTarget "developmental process abnormalities" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_602 ; owl:annotatedTarget "An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_603 ; owl:annotatedTarget "Anatomically located instance of pathological response or entity." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "CAS:601-75-2" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_607 ; owl:annotatedTarget "Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_608 ; owl:annotatedTarget "A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_62 ; owl:annotatedTarget "Formation of an epithelium bounded cavity not associated with neoplasia." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_622 ; owl:annotatedTarget "Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_622 ; owl:annotatedTarget "adipose degeneration" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_622 ; owl:annotatedTarget "fatty change" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_622 ; owl:annotatedTarget "fatty degeneration" . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_64 ; owl:annotatedTarget "Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_66 ; owl:annotatedTarget "Increase in the diameter of an orifice or tubular structure beyond its normal dimensions." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_68 ; owl:annotatedTarget "A blind ended outpouching through the wall of a tubular organ or bounded cavity." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "CAS:601-75-2" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_70 ; owl:annotatedTarget "An abnormal passage between two internal organs or leading from a cavity to the body surface." . [] oboInOwl:hasDbXref ":" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_718 ; owl:annotatedTarget "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine." . [] oboInOwl:hasDbXref "ISBN:0781727286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_74 ; owl:annotatedTarget "A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_86 ; owl:annotatedTarget "Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_89 ; owl:annotatedTarget "Abnormal development of the heart or vascular tissue resulting in morphological abnormality." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_90 ; owl:annotatedTarget "Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber." . [] oboInOwl:hasDbXref "Pathbase: Pathology Committee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:MPATH_98 ; owl:annotatedTarget "A stretching and widening of the lymphatic vessels." . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_98 ; owl:annotatedTarget "Lymphectasia" . [] oboInOwl:hasDbXref "Pathbase: Curation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:MPATH_98 ; owl:annotatedTarget "telangiectasia lymphatica" . [] oboInOwl:source "wikipedia:Emotions" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000003 ; owl:annotatedTarget "Behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "PMID:20187168" . [] oboInOwl:source "GO:jic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000006 ; owl:annotatedTarget "Behavior related to the acquisition and processing of information and/or the storage and retrieval of this information over time." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000009 ; owl:annotatedTarget "Observable characteristic of behavior associated with the specific movement from place to place of an organism." . [] oboInOwl:source "wikipedia:Aggression" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000015 ; owl:annotatedTarget "A behavioral interaction between organisms in which one organism has the intention of inflicting damage on another individual using physical or verbal means." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000018 ; owl:annotatedTarget "Emotional behavior related to fear or anxiety." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000024 ; owl:annotatedTarget "Behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15740 ; owl:annotatedTarget "methanoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "PMID:22133302" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000030 ; owl:annotatedTarget "A kinesthetic behavior which relatively increased." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000034 ; owl:annotatedTarget "Behaviour related to the activity which primary purpose is the sexual reproduction." . [] oboInOwl:hasDbXref "PMID:29327315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000043 ; owl:annotatedTarget "A behavior that occurs between two individuals, such as parent and child, and involves an emotional attachment that implies a special and focused relationship." . [] oboInOwl:source "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000054 ; owl:annotatedTarget "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000063 ; owl:annotatedTarget "A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of food." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000064 ; owl:annotatedTarget "A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of liquids." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "PMID:23161776" . [] oboInOwl:source "wikipedia:Depression" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000085 ; owl:annotatedTarget "Emotional behavior related to a state of low mood and aversion to activity." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000092 ; owl:annotatedTarget "An emotional behavior related to a feeling of uneasiness or nervousness triggered by an identifiable triggering stimulus." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000096 ; owl:annotatedTarget "A phobia characterised by fear of open spaces." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000119 ; owl:annotatedTarget "A behavior that occur quickly without control, planning, or consideration of the consequences of that behavior." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "PMID:6860317" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000120 ; owl:annotatedTarget "An aggressive behavior that aims to inflicting damage on another entity using physical means." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000128 ; owl:annotatedTarget "Behavior characterized by a quick excitability to annoyance, impatience, or anger." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000129 ; owl:annotatedTarget "Emotional behavior related to excitement or restlessness." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000130 ; owl:annotatedTarget "A behavior associated with the intake of liquid." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "Reaxys:774334" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000134 ; owl:annotatedTarget "A feeding behavior associated with the intake of food." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "ethylpropanedioic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "1,1-propanedicarboxylic acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "2-ethylmalonic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_741548 ; owl:annotatedTarget "alpha-carboxybutyric acid" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000162 ; owl:annotatedTarget "Duration of REM sleep." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000170 ; owl:annotatedTarget "Behavior related with the ability of an organism's ability to store, retain, and recall information and experiences." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74222 ; owl:annotatedTarget "gamma-lactams" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000229 ; owl:annotatedTarget "Observable characteristic of behavior related to the awareness of body balance and movement." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000233 ; owl:annotatedTarget "Behavior related to the tendency of an organism to maintain internal equilibrium." . [] oboInOwl:source "NBO:RH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000243 ; owl:annotatedTarget "An observable characteristic of the behavior of an organism." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000246 ; owl:annotatedTarget "A pathological anxiety characterized by fear or anxiety triggered by a specific stimulus or situation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74223 ; owl:annotatedTarget "2-pyrrolidinones" . [] oboInOwl:source "NBO:RH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000266 ; owl:annotatedTarget "Observable characteristic of behaviour related to cognitive processes." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000270 ; owl:annotatedTarget "Observable characteristic of behavior associated with the intake of food or liquids." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000304 ; owl:annotatedTarget "Behavior related with the gradual loss of information and experiences stored in the memory of an organism." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000308 ; owl:annotatedTarget "Cognitive perception of a sensation by any of the five senses -- vision, touch, smell, taste, and hearing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74223 ; owl:annotatedTarget "2-pyrrolidones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74223 ; owl:annotatedTarget "pyrrolidine-2-ones" . [] oboInOwl:source "MBP:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000317 ; owl:annotatedTarget "Behavior related to the awareness of body balance and movement." . [] oboInOwl:source "OBP:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000327 ; owl:annotatedTarget "Behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000347 ; owl:annotatedTarget "The coordination of large muscle groups and whole body movement." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000355 ; owl:annotatedTarget "Intentionally or habitually assumed arrangement of the body and its limbs." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000356 ; owl:annotatedTarget "Intentionally or habitually assumed arrangement of the body." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000357 ; owl:annotatedTarget "Intentionally or habitually assumed arrangement of the limbs." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000388 ; owl:annotatedTarget "Behavior related to movements that occur independent of planning." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_74337 ; owl:annotatedTarget "(2R)-4-amino-2-azaniumyl-4-oxobutanoate" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000389 ; owl:annotatedTarget "Behavior related to involuntary movement in response to a stimulus." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000403 ; owl:annotatedTarget "Behavior related to movements executed with intent." . [] oboInOwl:source "wikipedia:Reflex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000411 ; owl:annotatedTarget "A reflex that involves cranial nerves." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74337 ; owl:annotatedTarget "(2R)-4-amino-2-ammonio-4-oxobutanoate" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000419 ; owl:annotatedTarget "Observable characteristic of behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." . [] oboInOwl:source "MBP:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000420 ; owl:annotatedTarget "A NREM parasomnia characterised by Involuntarily grinding of teeth while sleeping." . [] oboInOwl:source "wikipedia:Attention" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000455 ; owl:annotatedTarget "The sustained focus of cognitive resources on information while filtering or ignoring extraneous information. Intended to encompass only attention to perceptual stimuli. " . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74337 ; owl:annotatedTarget "D-asparagine" . [] oboInOwl:source "wikipedia:Parasomnia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000493 ; owl:annotatedTarget "A sleeping behavior phenotype that involve abnormal and unnatural movements, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000499 ; owl:annotatedTarget "A type of parasomnia that occurs during NREM sleep." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000539 ; owl:annotatedTarget "Observable characteristic of feeding behavior that relates to eating." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000540 ; owl:annotatedTarget "Observable characteristic of feeding behavior that relates to drinking." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_74345 ; owl:annotatedTarget "PMID:20826786" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000541 ; owl:annotatedTarget "A pathological drinking behavior characterised by an excessive desire to drink." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_74345 ; owl:annotatedTarget "1-(5-hydroxy-2-oxo-2,3-dihydro-1H-imidazol-4-yl)urea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74345 ; owl:annotatedTarget "2-oxo-4-hydroxy-5-ureidoimidazoline" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000542 ; owl:annotatedTarget "A pathological drinking behavior characterised by large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74345 ; owl:annotatedTarget "allantoin, enol-form" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000543 ; owl:annotatedTarget "A pathological drinking behavior characterised by an excessive relative temporal desire to drink." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000544 ; owl:annotatedTarget "A pathological feeding behavior characterised by failure to eat." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74783 ; owl:annotatedTarget "adstringent" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000546 ; owl:annotatedTarget "A pathological eating behavior characterised by an abnormally large intake of food by mouth, usually due to excessive hunger that is relatively prolonged." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74783 ; owl:annotatedTarget "adstringents" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000564 ; owl:annotatedTarget "Observable characteristic of behavior that occurs predominantly or only, in individuals that are part of a group." . [] oboInOwl:source "wikipedia:Stereotypy" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000567 ; owl:annotatedTarget "A pathological behavior associated with repetitive or ritualistic movement, posture, or utterance." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000568 ; owl:annotatedTarget "Observable characteristic of behavior related to the movement of the body's muscles, tendons, and joints." . [] oboInOwl:source "JAX:" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000586 ; owl:annotatedTarget "A form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000587 ; owl:annotatedTarget "A sudden, involuntary contraction of a muscle or group of muscles associated with strychnine poisoning and tetanus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_74783 ; owl:annotatedTarget "astringents" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000588 ; owl:annotatedTarget "A sudden, involuntary contraction of a muscle or group of muscles." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000589 ; owl:annotatedTarget "An involuntary rhythmical, oscillatory movement of a body part." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000591 ; owl:annotatedTarget "Observable characteristic of behavior related to the coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions." . [] oboInOwl:source "wikipedia:Dystonia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000598 ; owl:annotatedTarget "A locomotory disorder in which sustained muscle contractions cause twisting and repetitive movements or abnormal postures." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75325 ; owl:annotatedTarget "cathartics" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000601 ; owl:annotatedTarget "Observable characteristic of behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." . [] oboInOwl:source "wikipedia:Delusion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000603 ; owl:annotatedTarget "A belief that is either mistaken or not substantiated that is held with vehemence." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C--N bond-forming ligase inhibitor" . [] oboInOwl:source "wikipedia:Forgetting" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000606 ; owl:annotatedTarget "Loss of information already encoded and stored in an individual's long term memory." . [] oboInOwl:source "NBO:JH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000607 ; owl:annotatedTarget "Behaviour related to cognitive processes." . [] oboInOwl:source "wikipedia:Hallucination" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000608 ; owl:annotatedTarget "Perception in the absence of a stimulus." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000609 ; owl:annotatedTarget "A form of hallucination that involves perceiving images without visual stimulus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C--N bond-forming ligase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C-N bond-forming ligase (EC 6.3.*) inhibitor" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000611 ; owl:annotatedTarget "A form of hallucination that involves perceiving odors without odor stimulus." . [] oboInOwl:source "wikipedia:Communication" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000612 ; owl:annotatedTarget "A social behavior related to the activity of conveying information." . [] oboInOwl:source "wikipedia:Frustration" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000620 ; owl:annotatedTarget "An emotional behavior that arises from the perceived resistance to the fulfillment of individual will." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000623 ; owl:annotatedTarget "Stereotypic behavior characterised by a tendency to repeat vocalizations." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000643 ; owl:annotatedTarget "Observable characteristic of behavior related to movements that occur independent of planning." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C-N bond-forming ligase (EC 6.3.*) inhibitors" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000644 ; owl:annotatedTarget "Observable characteristic of behavior related to movements executed with intent." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C-N bond-forming ligase inhibitor" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000655 ; owl:annotatedTarget "Observable characteristic of behavior related any of the five senses -- vision, touch, smell, taste, and hearing." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000656 ; owl:annotatedTarget "A phenotype manifested by a behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "C-N bond-forming ligase inhibitors" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000754 ; owl:annotatedTarget "Observable characteristic of behavior related to the stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000755 ; owl:annotatedTarget "Observable characteristic of behavior related to the actions or interactions of an organism that are associated with reproduction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "EC 6.3.* (C-N bond-forming ligase) inhibitorS" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000756 ; owl:annotatedTarget "Observable characteristic of behavior related to the interactions between organisms for the purpose of mating." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "EC 6.3.* inhibitor" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000758 ; owl:annotatedTarget "Observable characteristic of behavior related to the activity which primary purpose is the sexual reproduction." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000762 ; owl:annotatedTarget "Observable characteristic of behavior related to the act of sexual union between male and female, involving the transfer of sperm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "EC 6.3.* inhibitors" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000765 ; owl:annotatedTarget "Observable characteristic of behaviour related to the acquisition and processing of information and/or the storage and retrieval of this information over time." . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0000767 ; owl:annotatedTarget "Observable characteristic of behaviour related to the ability of an organism's ability to store, retain, and recall information and experiences." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "EC 6.3.*.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75600 ; owl:annotatedTarget "EC 6.3.*.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "EC 6.* (ligase) inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "EC 6.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "EC 6.* inhibitors" . [] oboInOwl:source "NBOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0001845 ; owl:annotatedTarget "Behavior related to the intake of substances." . [] oboInOwl:source "NBOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0002169 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of consumption behavior, the specific actions or reactions of an organism in response to external or internal stimuli." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "EC 6.*.*.* inhibitor" . [] oboInOwl:source "NBOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0002436 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of consumption of food or liquid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "EC 6.*.*.* inhibitors" . [] oboInOwl:source "NBO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0002519 ; owl:annotatedTarget "A pathological drinking behavior characterised by a lack of desire to drink." . [] oboInOwl:source "NBOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:NBO_0002603 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sexual activity, the specific actions or reactions of an organism in response to external or internal stimuli." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000001 ; owl:annotatedTarget "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "ligase inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000004 ; owl:annotatedTarget "A quality of inhering in a bearer by virtue of the bearer's disposition to move freely." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000014 ; owl:annotatedTarget "A composite chromatic quality composed of hue, saturation and intensity parts." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000016 ; owl:annotatedTarget "A scalar optical property that is the intensity, value or amount of perceived light." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000017 ; owl:annotatedTarget "A scalar chromatic property that is the degree of purity of perceived light." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000025 ; owl:annotatedTarget "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/concentration" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000033 ; owl:annotatedTarget "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/frequency" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000044 ; owl:annotatedTarget "A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time." . [] oboInOwl:hasDbXref "MGED:MGED" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000047 ; owl:annotatedTarget "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000048 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000049 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75603 ; owl:annotatedTarget "ligase inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000050 ; owl:annotatedTarget "A time quality inhering in a bearer by virtue of the bearer's expected maximum age." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000051 ; owl:annotatedTarget "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000052 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000057 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000060 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000069 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000070 ; owl:annotatedTarget "The number of entities of this type that are part of the whole organism." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000078 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's movement or variation characterized by the regular recurrence or alternation of different quantities or conditions." . [] oboInOwl:hasDbXref "reference.com:reference.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000082 ; owl:annotatedTarget "A rhythm quality inhering in a bearer by virtue of the repetitiveness of bearer's rhythm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C--C bond-forming ligase inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000085 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000117 ; owl:annotatedTarget "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000119 ; owl:annotatedTarget "A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000122 ; owl:annotatedTarget "A 1-D extent quality which is equal to the distance between two points." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000125 ; owl:annotatedTarget "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." . [] oboInOwl:hasDbXref "PATOC:JE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000133 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object." . [] oboInOwl:hasDbXref "PATOC:CJM", "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000136 ; owl:annotatedTarget "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000140 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000141 ; owl:annotatedTarget "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." . [] oboInOwl:hasDbXref "VT:1000738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PATO_0000141 ; owl:annotatedTarget "conformation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C--C bond-forming ligase inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000150 ; owl:annotatedTarget "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." . [] oboInOwl:hasDbXref "PATOC:melissa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000161 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000165 ; owl:annotatedTarget "A quality in which events occur in sequence." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000186 ; owl:annotatedTarget "An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000188 ; owl:annotatedTarget "A behavioral quality inhering in a bearer by virtue of the bearer's having or lacking skillful and effective interaction of movement." . [] oboInOwl:hasDbXref "Merriam-Webster:Merriam-Webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000261 ; owl:annotatedTarget "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000274 ; owl:annotatedTarget "A reproductive quality inhering in a bearer by virtue of the bearer's initiating, sustaining, or supporting reproduction." . [] oboInOwl:hasDbXref "PATOC:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000297 ; owl:annotatedTarget "A quality of a process which ends earlier than the natural end time or reference process." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000299 ; owl:annotatedTarget "A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C-C bond-forming ligase (EC 6.4.*) inhibitor" . [] oboInOwl:hasDbXref "Dictionary:http://dictionary.reference.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000318 ; owl:annotatedTarget "A color hue with low wavelength of that portion of the visible spectrum lying between green and indigo, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 490 nanometers." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000319 ; owl:annotatedTarget "A color consisting of green and blue hue." . [] oboInOwl:hasDbXref "Dictionary:http://dictionary.reference.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000320 ; owl:annotatedTarget "A color hue with medium-low wavelength of that portion of the visible spectrum lying between yellow and blue, evoked in the human observer by radiant energy with wavelengths of approximately 490 to 570 nanometers." . [] oboInOwl:hasDbXref "Dictionary:http://dictionary.reference.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000322 ; owl:annotatedTarget "A color hue with high wavelength of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately 630 to 750 nanometers." . [] oboInOwl:hasDbXref "Dictionary:http://dictionary.reference.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000323 ; owl:annotatedTarget "An achromatic color of maximum brightness; the color of objects that reflect nearly all light of all visible wavelengths." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000328 ; owl:annotatedTarget "A color saturation which is of low purity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000330 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C-C bond-forming ligase (EC 6.4.*) inhibitorS" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000380 ; owl:annotatedTarget "A frequency which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000381 ; owl:annotatedTarget "A frequency which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C-C bond-forming ligase inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000386 ; owl:annotatedTarget "A hardness quality of being rigid and resistant to pressure." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000387 ; owl:annotatedTarget "A hardness quality of giving little resistance to pressure." . [] oboInOwl:hasDbXref "dictionary:reference" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000389 ; owl:annotatedTarget "A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000394 ; owl:annotatedTarget "An intensity which is less than moderate in type or degree or effect or force." . [] oboInOwl:hasDbXref "Merriam-Webster:Merriam-Webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000395 ; owl:annotatedTarget "An intensity which is less than extreme in type or degree or effect or force." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "C-C bond-forming ligase inhibitors" . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000396 ; owl:annotatedTarget "An intensity which is extremely bad or unpleasant in type or degree or effect or force." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000402 ; owl:annotatedTarget "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000403 ; owl:annotatedTarget "A concave quality inhering in a bearer by virtue of the bearer's resembling a groove or fissure." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000404 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals)." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000405 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000406 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend." . [] oboInOwl:hasDbXref "web:http://www.merriam-webster.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000407 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000411 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000413 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000427 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's occurring or appearing again or repeatedly." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "EC 6.4.* (C-C bond-forming ligase) inhibitorS" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000440 ; owl:annotatedTarget "A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000460 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000461 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." . [] oboInOwl:hasDbXref "thefreedictionary.:thefreedictionary." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000462 ; owl:annotatedTarget "A quality denoting the lack of an entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000467 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's existence." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "EC 6.4.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000470 ; owl:annotatedTarget "An amount which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000498 ; owl:annotatedTarget "A duration quality of a process which is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "EC 6.4.* inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000499 ; owl:annotatedTarget "A duration quality of a process which is relatively low." . [] oboInOwl:hasDbXref "PATOC:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000502 ; owl:annotatedTarget "A quality of a process which starts later than the natural start time or the reference process." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000516 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000547 ; owl:annotatedTarget "A photosensitivity quality inhering in a bearer by virtue of the bearer's exhibiting photosensitivity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000569 ; owl:annotatedTarget "A height which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "EC 6.4.*.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000570 ; owl:annotatedTarget "A height which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000573 ; owl:annotatedTarget "A length quality which is relatively large." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75604 ; owl:annotatedTarget "EC 6.4.*.* inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000574 ; owl:annotatedTarget "A length quality which is relatively small." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000584 ; owl:annotatedTarget "An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ)." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000585 ; owl:annotatedTarget "A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75763 ; owl:annotatedTarget "eukaryotic metabolites" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000586 ; owl:annotatedTarget "A size quality which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000587 ; owl:annotatedTarget "A size quality which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75767 ; owl:annotatedTarget "animal metabolites" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000591 ; owl:annotatedTarget "A thickness which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000592 ; owl:annotatedTarget "A thickness which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75768 ; owl:annotatedTarget "mammalian metabolites" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000595 ; owl:annotatedTarget "A volume which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000596 ; owl:annotatedTarget "A volume which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000599 ; owl:annotatedTarget "A width which is relatively small." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000600 ; owl:annotatedTarget "A width which is relatively large." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000608 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000609 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's affording not completed blocked passage or view." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000610 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000614 ; owl:annotatedTarget "A pattern where all the repeated elements are oriented in the same direction." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000616 ; owl:annotatedTarget "A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000617 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000618 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000619 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being overfilled." . [] oboInOwl:hasDbXref "sdvc:sdvc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000623 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's protruding or projecting from the body." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000625 ; owl:annotatedTarget "An oriented quality inhering in a bearer by virtue of the bearer's being reversed in position, order, or condition." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000627 ; owl:annotatedTarget "A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000628 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000632 ; owl:annotatedTarget "A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division by a longitudinal plane into similar halves." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Beilstein:607489" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:22743781" . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000634 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's involvement of only one part or side." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000635 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's not being confined or restricted to a particular location." . [] oboInOwl:hasDbXref "PATOC:PortlandMeetingFeb2015", "PATOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000639 ; owl:annotatedTarget "A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000640 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's exhibiting an alteration in size, shape or organization of its constituent cells." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000642 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity." . [] oboInOwl:hasDbXref "spinalstenosis:spinalstenosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000643 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it." . [] oboInOwl:hasDbXref "Wikipedia:Hyperplasia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000644 ; owl:annotatedTarget "A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting an increased number of cells, typically associated with an increase in size." . [] oboInOwl:hasDbXref "PATOC:GVG", "Wikipedia:Hypoplasia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000645 ; owl:annotatedTarget "A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting a decreased number of cells, typically associated with a decrease in size." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000646 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:23093174" . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Necrotic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000647 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's undergoing unprogrammed cell death." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000648 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's being blocked or filled with obstacles or an obstacle." . [] oboInOwl:hasDbXref "PATOC:nw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000651 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's being no longer merged with another entity." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000665 ; owl:annotatedTarget "A color brightness which is relatively high." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000688 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's not occurring or existing at the same time or having the same period or phase." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000689 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000692 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's origin or development at an unusual time or out of the regular sequence." . [] oboInOwl:hasDbXref "PATO:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000694 ; owl:annotatedTarget "A quality of a process which starts earlier than the natural start time or the reference process." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000700 ; owl:annotatedTarget "A texture quality inhering in a bearer by virtue of the bearer's irregular surface." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000701 ; owl:annotatedTarget "A texture quality inhering in a bearer by virtue of the bearer's processing a surface free of roughness or irregularities." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:23238962" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000760 ; owl:annotatedTarget "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting increased activity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000761 ; owl:annotatedTarget "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting reduced activity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:23449527" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000763 ; owl:annotatedTarget "A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000890 ; owl:annotatedTarget "A male fertility quality inhering in a male by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000892 ; owl:annotatedTarget "A female fertility quality inhering in a female by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000911 ; owl:annotatedTarget "A rate which is relatively low." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:23462586" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000912 ; owl:annotatedTarget "A rate which is relatively high." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000915 ; owl:annotatedTarget "A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000918 ; owl:annotatedTarget "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000921 ; owl:annotatedTarget "A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000927 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy." . [] oboInOwl:hasDbXref "PATOC:mh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000941 ; owl:annotatedTarget "A structural quality inhering in a cytoplasm that contains fluid filled cavities." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000944 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000946 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having a somewhat elongated form with approximately parallel sides." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "PMID:23690582" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000947 ; owl:annotatedTarget "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." . [] oboInOwl:hasDbXref "http://en.wikipedia.org/wiki/Grey" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000950 ; owl:annotatedTarget "A color between white and black colors." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000956 ; owl:annotatedTarget "A fertility quality inhering in a bearer by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000957 ; owl:annotatedTarget "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000963 ; owl:annotatedTarget "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000964 ; owl:annotatedTarget "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000965 ; owl:annotatedTarget "A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000967 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having a sinuate margin and rippled surface." . [] oboInOwl:hasDbXref "Answers.com:Answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000969 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of the bearer's being abnormally small." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000992 ; owl:annotatedTarget "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "B vitamins" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0000998 ; owl:annotatedTarget "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001018 ; owl:annotatedTarget "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001019 ; owl:annotatedTarget "A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001020 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001025 ; owl:annotatedTarget "A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts." . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001031 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001043 ; owl:annotatedTarget "A quality inhering in an entity by virtue of the bearer's propensity to resist an external stimulus." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001046 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001152 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's having susceptibilty toward an external stimulus." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001154 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "B-group vitamin" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001159 ; owl:annotatedTarget "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001162 ; owl:annotatedTarget "A concentration which is higher relative to the normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "B-group vitamins" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001163 ; owl:annotatedTarget "A concentration which is lower relative to the normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001164 ; owl:annotatedTarget "A physical quality which inheres in a bearer by virtue of the bearer's exhibiting density." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001167 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired." . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001171 ; owl:annotatedTarget "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001178 ; owl:annotatedTarget "A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001190 ; owl:annotatedTarget "A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed." . [] oboInOwl:hasDbXref "PATOC:nw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001195 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001201 ; owl:annotatedTarget "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter Y." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001230 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's power or force." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001236 ; owl:annotatedTarget "A quality which inheres in an process." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75769 ; owl:annotatedTarget "vitamin B" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001241 ; owl:annotatedTarget "A quality which inheres in a continuant." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001292 ; owl:annotatedTarget "An EM radiation quality that is independent of the EM wavelength range." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001294 ; owl:annotatedTarget "A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001297 ; owl:annotatedTarget "A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001300 ; owl:annotatedTarget "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001301 ; owl:annotatedTarget "An optical quality that is the mixture, purity or pattern of wavelengths of light perceived by the observer." . [] oboInOwl:hasDbXref "Dictionary:http://dictionary.reference.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001303 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing." . [] oboInOwl:hasDbXref "PATOC:mellybelly" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001309 ; owl:annotatedTarget "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." . [] oboInOwl:hasDbXref "PATOC:melissa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001333 ; owl:annotatedTarget "A quality of a process which ends later than the natural end time." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "CAS:57-10-3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75771 ; owl:annotatedTarget "Mus musculus metabolite" . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Diameter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001334 ; owl:annotatedTarget "A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001354 ; owl:annotatedTarget "A optical quality inhering in a bearer by virtue of the bearer's exhibiting low opacity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001355 ; owl:annotatedTarget "A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001362 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's disposition to being easily damaged or destroyed." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Ploidy" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001374 ; owl:annotatedTarget "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Haploid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001375 ; owl:annotatedTarget "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Euploid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001393 ; owl:annotatedTarget "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Diploid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001394 ; owl:annotatedTarget "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001396 ; owl:annotatedTarget "A monadic quality of continuant that exists at the cellular level of organisation." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001397 ; owl:annotatedTarget "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75771 ; owl:annotatedTarget "Mus musculus metabolites" . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Unipotent" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001400 ; owl:annotatedTarget "A cellular potency that is the capacity to produce only one differentiated cell type." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001401 ; owl:annotatedTarget "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Multipotent" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001402 ; owl:annotatedTarget "A cellular potency that is the capacity to form multiple differentiated cell types." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001404 ; owl:annotatedTarget "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." . [] oboInOwl:hasDbXref "Biology-online:Biology-online" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001405 ; owl:annotatedTarget "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." . [] oboInOwl:hasDbXref "Biology-online:Biology-online" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001406 ; owl:annotatedTarget "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." . [] oboInOwl:hasDbXref "Biology-online:Biology-online" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001407 ; owl:annotatedTarget "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Ciliated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001408 ; owl:annotatedTarget "A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body." . [] oboInOwl:hasDbXref "Biology-online:Biology-online" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001409 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's resembling a long tapered rod." . [] oboInOwl:hasDbXref "Biology-online:Biology-online" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001410 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75771 ; owl:annotatedTarget "mouse metabolites" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001419 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001434 ; owl:annotatedTarget "An organismal quality inhering in a bearer by virtue of the bearer's ability to produce new life or offspring." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001435 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001439 ; owl:annotatedTarget "A contractile quality inhering in a bearer by virtue of the bearer's elastic tension that facilitate response to stimuli." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001442 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of whether the bearer includes all its components." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4606-0597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001444 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's components no longer being in a single contiguous unit." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001447 ; owl:annotatedTarget "A composition quality inhering in an bearer by virtue of the bearer's being encrusted or impregnated with calcium carbonate (CHEBI:3311)." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Cartilaginous" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001449 ; owl:annotatedTarget "A composition quality inhering in an bearer by virtue of the bearer's cartilage quantities." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001450 ; owl:annotatedTarget "A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001453 ; owl:annotatedTarget "An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "S. cerevisiae metabolite" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001457 ; owl:annotatedTarget "A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001468 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the back or upper surface of an organism." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001469 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the abdomen of an organism." . [] oboInOwl:hasDbXref "PATOC:nw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001470 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's magnitude in respect to a related entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001472 ; owl:annotatedTarget "A depth which is relatively low." . [] oboInOwl:hasDbXref "Dictionary.com:Dictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001473 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's being present in two copies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "S. cerevisiae metabolites" . [] oboInOwl:hasDbXref "bdid:bdid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001474 ; owl:annotatedTarget "An oriented quality inhering in a bearer by virtue of the bearer's axis being positioned forward." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001475 ; owl:annotatedTarget "A position which is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "S. cerevisiae secondary metabolite" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001476 ; owl:annotatedTarget "A positional which is relatively low." . [] oboInOwl:hasDbXref "Dictionary.com:Dictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001477 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being drawn in or pulled back from any given point." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001481 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction." . [] oboInOwl:hasDbXref "Dictionary.com:Dictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001482 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's standing out or projecting beyond a surface or line." . [] oboInOwl:hasDbXref "PATOC:GVG", "PATOC:PortlandMeetingFeb2015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001483 ; owl:annotatedTarget "Absence of an organ, tissue or cell due to failure to develop from a primordium or precursor cell." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001488 ; owl:annotatedTarget "A cellular quality inhering in a cell by virtue of whether the bearer exhibits the ability to move spontaneously." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001495 ; owl:annotatedTarget "A concave quality inhering in a bearer by virtue of the bearer's shape being a V-shaped cut." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "S. cerevisiae secondary metabolites" . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001499 ; owl:annotatedTarget "A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter)." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001500 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end." . [] oboInOwl:hasDbXref "Merriam-Webster:Merriam-Webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001501 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001505 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001507 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001509 ; owl:annotatedTarget "A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s)." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001510 ; owl:annotatedTarget "A functionality quality held by the bearer when the latter is able to perform a regular function(s)." . [] oboInOwl:hasDbXref "PATC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001511 ; owl:annotatedTarget "A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s)." . [] oboInOwl:hasDbXref "medical-dictionary:medical-dictionary" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001512 ; owl:annotatedTarget "A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "Saccharomyces cerevisiae metabolites" . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001543 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking." . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001544 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking." . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001545 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking." . [] oboInOwl:hasDbXref "Chemistry:http://chemistry.about.com/od/chemistryglossary/a/soliddefinition.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001546 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." . [] oboInOwl:hasDbXref "Chemistry:http://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm", "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001547 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." . [] oboInOwl:hasDbXref "url:http://www.chemistry-dictionary.com/definition/liquid.php" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001548 ; owl:annotatedTarget "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "Saccharomyces cerevisiae secondary metabolites" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001549 ; owl:annotatedTarget "A sensitivity toward an external stimulus which is higher than normal/average." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001550 ; owl:annotatedTarget "A sensitivity toward an external stimulus which is lower than normal/average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "baker's yeast metabolite" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001551 ; owl:annotatedTarget "A sensitivity of a process which is higher than normal or average." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001552 ; owl:annotatedTarget "A sensitivity of a process which is lower than normal or average." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001555 ; owl:annotatedTarget "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001558 ; owl:annotatedTarget "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "CAS:57-10-3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "baker's yeast metabolites" . [] oboInOwl:hasDbXref "PATO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001559 ; owl:annotatedTarget "A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s)." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001561 ; owl:annotatedTarget "A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "baker's yeast secondary metabolite" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001562 ; owl:annotatedTarget "A mass which is lower than normal or average." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001563 ; owl:annotatedTarget "A mass which is higher than normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001564 ; owl:annotatedTarget "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001571 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75772 ; owl:annotatedTarget "baker's yeast secondary metabolites" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001575 ; owl:annotatedTarget "A pressure which is relatively low." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001576 ; owl:annotatedTarget "A pressure which is relatively high." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001579 ; owl:annotatedTarget "A physical quality that is the ability to contract or shrink." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_75787 ; owl:annotatedTarget "prokaryotic metabolites" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001580 ; owl:annotatedTarget "A contractility which is relatively high." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001581 ; owl:annotatedTarget "A contractility which is relatively low." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001590 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's coinciding spatially, partially or wholly with another entity." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001591 ; owl:annotatedTarget "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001592 ; owl:annotatedTarget "A curvature which is relatively high." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_76042 ; owl:annotatedTarget "MetaCyc:Aromatic-Amino-Acids" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001593 ; owl:annotatedTarget "A curvature which is relatively low." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001594 ; owl:annotatedTarget "A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001595 ; owl:annotatedTarget "A 1-D extent quality inhering in a bearer by virtue of the bearer's downward or backward or inward dimension." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001596 ; owl:annotatedTarget "A depth quality which is relatively high." . [] oboInOwl:hasDbXref "thefreedictionary:thefreedictionary" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001597 ; owl:annotatedTarget "An oriented quality inhering in a bearer by virtue of the bearer's being turned outward in placement." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001598 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76042 ; owl:annotatedTarget "an aromatic amino-acid" . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001599 ; owl:annotatedTarget "An oriented quality inhering in a bearer by virtue of the bearer's being relocated around an axis." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001600 ; owl:annotatedTarget "A rotation quality inhering in a bearer by virtue of being rotated towards the rear of organism." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001602 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001603 ; owl:annotatedTarget "A life span which is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76042 ; owl:annotatedTarget "aromatic amino-acid zwitterions" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001604 ; owl:annotatedTarget "A life span which is relatively low." . [] oboInOwl:hasDbXref "Merriam-Webster:Merriam-Webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001608 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's being marked by, consisting of, or diversified with patches." . [] oboInOwl:hasDbXref "biology.lsu:biology.lsu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001609 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's being scattered; spread irregularly, and at a distance from each other." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001617 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76206 ; owl:annotatedTarget "xenobiotic metabolites" . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001618 ; owl:annotatedTarget "A tonicity which is relatively high." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001619 ; owl:annotatedTarget "A tonicity which is relatively low." . [] oboInOwl:hasDbXref "Wiikipedia:Wasting", "Wikipedia:Atrophy" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001623 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of a part or parts of the bearer's being decreased in size due to reduction in tissue mass through wasting." . [] oboInOwl:hasDbXref "PATO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001624 ; owl:annotatedTarget "A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s)." . [] oboInOwl:hasDbXref "PATO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001625 ; owl:annotatedTarget "A functional quality held by the bearer when the latter exhibits increased ability to perform a regular function(s)." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001626 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of whether the bearer has enough functionality." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001628 ; owl:annotatedTarget "A wholeness quality inhering in a bearer by virtue of the bearer's lacks enough functionality." . [] oboInOwl:hasDbXref "PATOC:nc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001645 ; owl:annotatedTarget "A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary into the surface or boundary of another entity." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "CAS:57-10-3" . [] oboInOwl:hasDbXref "PATOC:nc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001646 ; owl:annotatedTarget "A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary and outwards in relation to the physical space occupied by another entity." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001648 ; owl:annotatedTarget "An 1-D extent quality which is equal to the length of the closed curve of a circle." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001649 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the side." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001650 ; owl:annotatedTarget "A resistance to a stimulus which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001651 ; owl:annotatedTarget "A resistance to a stimulus which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001652 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001654 ; owl:annotatedTarget "An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning with respect to an additional entity." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001662 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's disposition to being damaged or destroyed." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "PMID:21886157" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001669 ; owl:annotatedTarget "A susceptibility toward an external stimulus which is higher than normal/average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001670 ; owl:annotatedTarget "A susceptibility toward an external stimulus which is lower than normal/average." . 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[] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001694 ; owl:annotatedTarget "A viscosity which relatively low." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "decanedioate" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001697 ; owl:annotatedTarget "A photosensitivity which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001698 ; owl:annotatedTarget "A photosensitivity which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001707 ; owl:annotatedTarget "A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting marked activity." . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "C10-DCA(2-)" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001708 ; owl:annotatedTarget "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001710 ; owl:annotatedTarget "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Perimeter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001711 ; owl:annotatedTarget "An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001712 ; owl:annotatedTarget "A perimeter which is relatively high." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "decanedioate" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001713 ; owl:annotatedTarget "A perimeter which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001714 ; owl:annotatedTarget "A diameter which is relatively large." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "decanedioate(2-)" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001715 ; owl:annotatedTarget "A diameter which is relatively small." . [] oboInOwl:hasDbXref "Merriam-Webster:Merriam-Webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001727 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's prevailing tendency, mood, or inclination." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001735 ; owl:annotatedTarget "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001748 ; owl:annotatedTarget "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76283 ; owl:annotatedTarget "sebacate" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001776 ; owl:annotatedTarget "A flexibility which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001777 ; owl:annotatedTarget "A flexibility which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76413 ; owl:annotatedTarget "greenhouse gases" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001778 ; owl:annotatedTarget "A strength which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001779 ; owl:annotatedTarget "A strength which is relatively low." . [] oboInOwl:hasDbXref "Wiikipedia:Wiikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001780 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of the bearer's being abnormally developed, usually due to malnutrition." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Gmelin:190200" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_76414 ; owl:annotatedTarget "PMID:22519407" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001782 ; owl:annotatedTarget "An intensity which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001783 ; owl:annotatedTarget "An intensity which is relatively low." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001784 ; owl:annotatedTarget "A branched quality inhering in a bearer by virtue of the bearer's being divided into two branches." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001785 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved outward." . [] oboInOwl:hasDbXref "die.net:die.net" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001786 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_76414 ; owl:annotatedTarget "PMID:24001847" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001787 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001788 ; owl:annotatedTarget "A density which is higher relative to the normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76414 ; owl:annotatedTarget "propellants" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001790 ; owl:annotatedTarget "A density which is lower relative to the normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001793 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity." . [] oboInOwl:hasDbXref "Online_Dictionary:Online_Dictionary" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001794 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001795 ; owl:annotatedTarget "A coiling which is relatively high." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_76579 ; owl:annotatedTarget "LIPID_MAPS_class:LMGL0301" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001796 ; owl:annotatedTarget "A coiling which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001800 ; owl:annotatedTarget "A composition quality inhering in an bearer by virtue of the quantities or relative ratios of water of the inhering entity." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Dehydrated" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001801 ; owl:annotatedTarget "A composition quality inhering in an bearer by virtue of the reduction in amount of water the bearer contains." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001802 ; owl:annotatedTarget "A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76579 ; owl:annotatedTarget "triradylglycerols" . [] oboInOwl:hasDbXref "url:http://www.thefreedictionary.com/wrinkled" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001810 ; owl:annotatedTarget "A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by one or more creases in a normally smooth surface." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001815 ; owl:annotatedTarget "A strength quality inhering in a bearer by virtue of the bearer's disposition to lose strength." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001816 ; owl:annotatedTarget "A fatigability which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001818 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001819 ; owl:annotatedTarget "A morphological quality inhering in a bearer by virtue of the bearer's absence or closure of a normal body orifice or tubular passage." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001821 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's having no opening." . [] oboInOwl:hasDbXref "wordreference.com:wordreference.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001822 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001824 ; owl:annotatedTarget "A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001827 ; owl:annotatedTarget "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001828 ; owl:annotatedTarget "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76619 ; owl:annotatedTarget "an omega-methyl fatty acid" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001829 ; owl:annotatedTarget "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001845 ; owl:annotatedTarget "A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm lacking pattern." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001847 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001848 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved asymmetrically." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001850 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's being fibrous tissue that replaces normal tissue destroyed by injury or disease." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001851 ; owl:annotatedTarget "A structure quality inhering in a bearer by virtue of the bearer's exhibiting transient abnormal enlargement, not due to cell proliferation." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001852 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position." . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001854 ; owl:annotatedTarget "A spatial pattern inhering in a bearer by virtue of the bearer's being situated at right angles to the horizon." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "C1-transferase (EC 2.1.*) inhibitor" . [] oboInOwl:hasDbXref "thefreedictionary.com:thefreedictionary.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001855 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being in the plane of the horizon." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001857 ; owl:annotatedTarget "A shape quality in a bearer by virtue of the bearer's curving inward." . [] oboInOwl:hasDbXref "PATOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001863 ; owl:annotatedTarget "A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Spheroid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001865 ; owl:annotatedTarget "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids." . [] oboInOwl:hasDbXref "PATOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001869 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001872 ; owl:annotatedTarget "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section)." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001873 ; owl:annotatedTarget "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." . [] oboInOwl:hasDbXref "PATOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001874 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "C1-transferase (EC 2.1.*) inhibitors" . [] oboInOwl:hasDbXref "wordreference:wordreference" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001875 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having three angles." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001876 ; owl:annotatedTarget "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two parts, roughly spherical and of equal size, connected by a bar." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001878 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped." . [] oboInOwl:hasDbXref "WordNet:WordNet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001879 ; owl:annotatedTarget "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter U." . [] oboInOwl:hasDbXref "MP:0000576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001883 ; owl:annotatedTarget "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's gradually becoming thicker towards the end." . [] oboInOwl:hasDbXref "InfoVisual:InfoVisual" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001890 ; owl:annotatedTarget "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being divided into three branches." . [] oboInOwl:hasDbXref "PATOC:mc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001891 ; owl:annotatedTarget "A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; egg-shaped." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "C1-transferase inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001898 ; owl:annotatedTarget "A circumference which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001899 ; owl:annotatedTarget "A circumference which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001908 ; owl:annotatedTarget "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." . [] oboInOwl:hasDbXref "PATOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001910 ; owl:annotatedTarget "A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "C1-transferase inhibitors" . [] oboInOwl:hasDbXref "PATOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001919 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the back or upper surface of an organism." . [] oboInOwl:hasDbXref "PATOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001921 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the front of an organism." . [] oboInOwl:hasDbXref "PATOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001922 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the rear of an organism." . [] oboInOwl:hasDbXref "PATOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001923 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the side of an organism." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001925 ; owl:annotatedTarget "A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001928 ; owl:annotatedTarget "A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer." . [] oboInOwl:hasDbXref "ISBN:0881923214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001937 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being oblong, with the lower end very much attenuated." . [] oboInOwl:hasDbXref "ISBN:0881923214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001938 ; owl:annotatedTarget "A spheroid quality inhering in a bearer by virtue of the bearer's being oval and a little angular in the middle." . [] oboInOwl:hasDbXref "PATOC:UMH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001940 ; owl:annotatedTarget "A size quality inhering in a bearer by virtue of the bearer's being many folds greater relative to the normal average." . [] oboInOwl:hasDbXref "PATOC:JE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001948 ; owl:annotatedTarget "A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by two or more parallel channels." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010001" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "EC 2.1.* (C1-transferase) inhibitors" . [] oboInOwl:hasDbXref "wordreference:wordreference" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001955 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001956 ; owl:annotatedTarget "A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001957 ; owl:annotatedTarget "A variability of size which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "EC 2.1.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001958 ; owl:annotatedTarget "A variability of size which is relatively high." . [] oboInOwl:hasDbXref "ISBN:0881923214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001973 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being tapering gradually into a rigid point." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001977 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having at least one salient angle on the margin." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001987 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." . [] oboInOwl:hasDbXref "url:http://www.oed.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001988 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001992 ; owl:annotatedTarget "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001993 ; owl:annotatedTarget "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001995 ; owl:annotatedTarget "A quality that inheres in an entire organism or part of an organism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "EC 2.1.* inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001997 ; owl:annotatedTarget "An amount which is relatively low." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0001999 ; owl:annotatedTarget "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002000 ; owl:annotatedTarget "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "one-carbon-containing group transferase inhibitor" . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002001 ; owl:annotatedTarget "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002002 ; owl:annotatedTarget "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002005 ; owl:annotatedTarget "Surface shape that refers to the inward or outward curvature of the surface." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002006 ; owl:annotatedTarget "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76655 ; owl:annotatedTarget "one-carbon-containing group transferase inhibitors" . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002007 ; owl:annotatedTarget "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." . [] oboInOwl:hasDbXref "PATOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002008 ; owl:annotatedTarget "A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002009 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." . [] oboInOwl:hasDbXref "PATOC:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002011 ; owl:annotatedTarget "A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002014 ; owl:annotatedTarget "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." . [] oboInOwl:hasDbXref "Wikipedia:http://en.wikipedia.org/wiki/Cone_(geometry)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002021 ; owl:annotatedTarget "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers)." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002026 ; owl:annotatedTarget "A quality of a single process inhering in a bearer by virtue of the bearer's not increasing over time." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002034 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being unseparated into parts or divisions." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "EC 1.* (oxidoreductase) inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002037 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002039 ; owl:annotatedTarget "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." . [] oboInOwl:hasDbXref "thefreedictionary:http://www.thefreedictionary.com/biconvexity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002040 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being convex on both sides or surface." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002041 ; owl:annotatedTarget "A diameter that is along the anterior-posterior axis." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002042 ; owl:annotatedTarget "An anterior-posterior diameter quality which is relatively small." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "EC 1.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002043 ; owl:annotatedTarget "An anterior-posterior diameter quality which is relatively large." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002044 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being a quadrilateral with two parallel sides." . [] oboInOwl:hasDbXref "PATOC:cvs" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002045 ; owl:annotatedTarget "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002049 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis and towards the side." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "EC 1.* inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002051 ; owl:annotatedTarget "An occurrence which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002052 ; owl:annotatedTarget "An occurrence which is relatively low." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "oxidoreductase (EC 1.*) inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002055 ; owl:annotatedTarget "A fragility which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002056 ; owl:annotatedTarget "A fragility which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002076 ; owl:annotatedTarget "A behavioral quality inhering in a bearer by virtue of the bearer's movement." . [] oboInOwl:hasDbXref "url:http://www.merriam-webster.com/dictionary/hollow" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002078 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002083 ; owl:annotatedTarget "Having extra or fewer parts." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "oxidoreductase (EC 1.*) inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002087 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's being short and wide and tapered distally." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002089 ; owl:annotatedTarget "A structure quality inhering in a bearer by virtue of the bearer's body containing more than one cyst - formations of sac-like closed membranous structures not associated with neoplasia." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002093 ; owl:annotatedTarget "A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002094 ; owl:annotatedTarget "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002096 ; owl:annotatedTarget "A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002097 ; owl:annotatedTarget "A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize." . [] oboInOwl:hasDbXref "answers.com:answers.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002112 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002118 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's being present in more than two copies." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002124 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002135 ; owl:annotatedTarget "A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:12492626" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "oxidoreductase inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002141 ; owl:annotatedTarget "A density quality which lacks pattern." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002149 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer exhibiting increased density resulting in exhibiting increased degree of radiopacity (in X-rays)." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002154 ; owl:annotatedTarget "A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the abdomen of an organism." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002155 ; owl:annotatedTarget "A rotation quality inhering in a bearer by virtue of being rotated towards the middle of an organism." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002156 ; owl:annotatedTarget "A rotation quality inhering in a bearer by virtue of being rotated towards the side of an organism." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002157 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being slightly out of its usual or proper place, or position." . [] oboInOwl:hasDbXref "mondofacto:mondofacto" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002161 ; owl:annotatedTarget "Having two horns or horn-shaped branches." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76725 ; owl:annotatedTarget "oxidoreductase inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002162 ; owl:annotatedTarget "A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002163 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it into the surface or boundary of another entity." . [] oboInOwl:hasDbXref "thefreedictionary.:thefreedictionary." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002165 ; owl:annotatedTarget "To bent or hang downwards." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002166 ; owl:annotatedTarget "A duration quality of a process inhering in a bearer by virtue of the bearer's premature completion of the closure of the opening of an anatomical entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002169 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being split along the median axis." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002175 ; owl:annotatedTarget "A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002176 ; owl:annotatedTarget "A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the side." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002177 ; owl:annotatedTarget "A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the middle." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002179 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue of the bearer's being positioned towards to point of attachment or origin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors" . [] oboInOwl:hasDbXref "merriam-webster:merriam-webster" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002180 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being free of curves, bends, or angles." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002181 ; owl:annotatedTarget "A positional quality inhering in a bearer by virtue the bearer's being changed in position." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002182 ; owl:annotatedTarget "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002198 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of its constitution." . [] oboInOwl:hasDbXref "merriam-webster:http://www.merriam-webster.com/dictionary/slender" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002212 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being small or narrow in circumference or width in proportion to length or height." . [] oboInOwl:hasDbXref "PATOC:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002254 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." . [] oboInOwl:hasDbXref "PATOC:JE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002255 ; owl:annotatedTarget "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." . [] oboInOwl:hasDbXref "PATOC:WD" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002257 ; owl:annotatedTarget "A cuscpidate quality inhering in a bearer by virtue of the bearer possessing more than one cusp." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002265 ; owl:annotatedTarget "A behavioral quality of a process inhering in a bearer by virtue of the bearer's disposition to exhibit marked activity." . [] oboInOwl:hasDbXref "PATOC:OREGON" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002266 ; owl:annotatedTarget "A shape that inheres in a 3 dimensional entity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "EC 1.1.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:CVC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002269 ; owl:annotatedTarget "A structural quality of the collection or massing of one physical object within another physical object." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002270 ; owl:annotatedTarget "An increased number of physical objects that are accumulated within another physical object usually as a result of a failure to break down or remove objects in a timely manner." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002281 ; owl:annotatedTarget "A cuscpidate quality inhering in a bearer by virtue of the bearer possessing two cusps." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002282 ; owl:annotatedTarget "A mobility which is relative high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "EC 1.1.* inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002283 ; owl:annotatedTarget "A mobility which is relative low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002287 ; owl:annotatedTarget "An elasticity which is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "inhibitor of oxidoreductase acting on CH-OH group of donor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002288 ; owl:annotatedTarget "An elasticity which is relatively low." . [] oboInOwl:hasDbXref "PATO:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002291 ; owl:annotatedTarget "Absence of a tissue or organ due to failure to develop." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002297 ; owl:annotatedTarget "A cellular motility which is lower relative to the normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "inhibitor of oxidoreductase acting on CH-OH group of donors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002298 ; owl:annotatedTarget "A cellular motility which is higher relative to the normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002299 ; owl:annotatedTarget "A cylindrical shape that is hollow." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002300 ; owl:annotatedTarget "A quality that has a value that is increased compared to normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "inhibitors of oxidoreductase acting on CH-OH group of donor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002301 ; owl:annotatedTarget "A quality that has a value that is decreased compared to normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002302 ; owl:annotatedTarget "A quality of a process that has a value that is decreased compared to normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "inhibitors of oxidoreductase acting on CH-OH group of donors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002303 ; owl:annotatedTarget "A quality of an object that has a value that is decreased compared to normal or average." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002304 ; owl:annotatedTarget "A quality of a process that has a value that is increased compared to normal or average." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002305 ; owl:annotatedTarget "A quality of an object that has a value that is increased compared to normal or average." . [] oboInOwl:hasDbXref "wikipedia:Parallelogram" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002317 ; owl:annotatedTarget """A convex quadrilateral is a parallelogram if and only if any one of the following statements are true: 1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation. 2. The opposite sides are congruent in pairs. 3. The diagonals bisect each other. 4. The opposite angles are congruent in pairs. 5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law) 6.It possesses rotational symmetry. 7.One pair of opposite sides are parallel and congruent. 8.Two pairs of adjacent angles are supplementary.""" . [] oboInOwl:hasDbXref "wiktionary:superellipse" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002318 ; owl:annotatedTarget "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" . [] oboInOwl:hasDbXref "PATOC:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002323 ; owl:annotatedTarget "A temporal distribution pattern of process occurrences within a regulation/reference process." . [] oboInOwl:hasDbXref "PATOC:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002324 ; owl:annotatedTarget "The temporal relation between the end of the process with respect to a reference process." . [] oboInOwl:hasDbXref "GOC:CJM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PATO_0002324 ; owl:annotatedTarget "completeness" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:15357969" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors" . [] oboInOwl:hasDbXref "GOC:CJM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PATO_0002324 ; owl:annotatedTarget "extent" . [] oboInOwl:hasDbXref "PATOC:LC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002325 ; owl:annotatedTarget "The temporal relation between the start of the process with respect to a reference process." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002326 ; owl:annotatedTarget "An orientation inhering in a bearer by virtue of the bearer's placement at an angle." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002327 ; owl:annotatedTarget "An angle which is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group inhibitor" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002328 ; owl:annotatedTarget "An angle which is relatively low." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002358 ; owl:annotatedTarget "An elongated raised margin or border." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002359 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the bearer's width being notably higher than its length." . [] oboInOwl:hasDbXref "PATOC:RH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002360 ; owl:annotatedTarget "A disposition that can be compared on a linear scale - that is that it can be increased or decreased." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76726 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group inhibitors" . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002361 ; owl:annotatedTarget "A tendency which is relatively high." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002362 ; owl:annotatedTarget "A tendency which is relatively low." . [] oboInOwl:hasDbXref "wikipedia:wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002400 ; owl:annotatedTarget "Having a spindle-like shape that is wide in the middle and tapers at both ends." . [] oboInOwl:hasDbXref "PATOC:MPTH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002403 ; owl:annotatedTarget "Affecting all regions without specificity of distribution." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002418 ; owl:annotatedTarget "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." . [] oboInOwl:hasDbXref "wikipedia:https://en.wikipedia.org/wiki/Acinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002422 ; owl:annotatedTarget "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "EC 3.* (hydrolase) inhibitors" . [] oboInOwl:hasDbXref "PATOC:WC" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002444 ; owl:annotatedTarget "A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material." . [] oboInOwl:hasDbXref "PATOC:WD" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002462 ; owl:annotatedTarget "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." . [] oboInOwl:hasDbXref "PATOC:WD" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002468 ; owl:annotatedTarget "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." . [] oboInOwl:hasDbXref "PATOC:DS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002478 ; owl:annotatedTarget "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." . [] oboInOwl:hasDbXref "PATOC:GVG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002505 ; owl:annotatedTarget "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." . [] oboInOwl:hasDbXref "PATOC:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002507 ; owl:annotatedTarget "A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin." . [] oboInOwl:hasDbXref "TheFreeDictionary:cancellous" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0002519 ; owl:annotatedTarget "A structural quality inhering in a bearer by virtue of the bearer's having an open, latticed, or porous structure; used especially of bone." . [] oboInOwl:hasDbXref "PATOC:WD" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0005021 ; owl:annotatedTarget "Cuspidate quality inhering in a bearer by virtue of the bearer's possessing a single cusp." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0010001 ; owl:annotatedTarget "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." . [] oboInOwl:hasDbXref "ORCID:0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0010006 ; owl:annotatedTarget "A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "EC 3.* inhibitor" . [] oboInOwl:hasDbXref "PATOC:PortlandMeetingFeb2015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0015001 ; owl:annotatedTarget "Absence due to a degenerative process." . [] oboInOwl:hasDbXref "GOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0015007 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the degree to which the bearers stands out or projects beyond a surface or line." . [] oboInOwl:hasDbXref "GOC:CJM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0015008 ; owl:annotatedTarget "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Fibrosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040019 ; owl:annotatedTarget "Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process." . [] oboInOwl:hasDbXref "https://medlineplus.gov/fractures.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040034 ; owl:annotatedTarget "A broken quality where an entity is cracked or broken, usually a bone." . [] oboInOwl:hasDbXref "https://www.mayoclinic.org/diseases-conditions/osteoporosis/multimedia/compression-fractures/img-20008995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040040 ; owl:annotatedTarget "A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Avulsion_fracture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040041 ; owl:annotatedTarget "A fractured quality in which the fragment of bone tears away from the main mass of bone as a result of physical trauma." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "EC 3.* inhibitors" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040042 ; owl:annotatedTarget "A proportionality quality inhering in a bearer by virtue of the bearer's decreased magnitude in respect to a related entity." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040043 ; owl:annotatedTarget "A proportionality quality inhering in a bearer by virtue of the bearer's increased magnitude in respect to a related entity." . [] oboInOwl:hasDbXref "https://www.dictionary.com/browse/unfragmented" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040047 ; owl:annotatedTarget "Existing or functioning as though broken into separate parts; disorganized; disunified." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0736-9199" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040048 ; owl:annotatedTarget "Red due to increase blood circulation in a defined area." . [] oboInOwl:hasDbXref "thefreedictionary.:thefreedictionary." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040058 ; owl:annotatedTarget "A quality denoting the lack of a physical entity or object, such as a chemical." . [] oboInOwl:hasDbXref "thefreedictionary.:thefreedictionary." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0040060 ; owl:annotatedTarget "A quality denoting the lack of an anatomical entity or cellular component." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "EC 3.*.*.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "EC 3.*.*.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "hydrolase (EC 3.*) inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "hydrolase (EC 3.*) inhibitors" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:1589452" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "hydrolase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76759 ; owl:annotatedTarget "hydrolase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "EC 3.1.* (ester hydrolase) inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "EC 3.1.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "EC 3.1.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "ester hydrolase (EC 3.1.*) inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "ester hydrolase (EC 3.1.*) inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "ester hydrolase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76760 ; owl:annotatedTarget "ester hydrolase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "EC 3.2.* (glycosylase) inhibitors" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:16509590" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "EC 3.2.* inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "EC 3.2.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "glycosylase (EC 3.2.*) inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "glycosylase (EC 3.2.*) inhibitors" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-9943-9018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0050000 ; owl:annotatedTarget "The number of repeated events per unit time, occurring in a repeating series. (e.g. the number of heart beats occurring over 1 minute)" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4148-4606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0055003 ; owl:annotatedTarget "A rate of occurrence that is relatively high." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "glycosylase inhibitor" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4148-4606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0055004 ; owl:annotatedTarget "A rate of occurrence that is relatively low." . [] oboInOwl:hasDbXref "PMID:18568015", "doi:10.1016/b978-0-12-369497-3.10004-4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0070006 ; owl:annotatedTarget "A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." . [] oboInOwl:hasDbXref "PMID:18568015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0070027 ; owl:annotatedTarget "A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0070046 ; owl:annotatedTarget "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0070047 ; owl:annotatedTarget "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-5111-7263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PATO_0070060 ; owl:annotatedTarget "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76761 ; owl:annotatedTarget "glycosylase inhibitors" . [] oboInOwl:hasDbXref "PRO:DAN", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000000001 ; owl:annotatedTarget "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000000001 ; owl:annotatedTarget "natural protein" . [] oboInOwl:hasDbXref "IEDB:BP" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000000001 ; owl:annotatedTarget "native protein" . [] oboInOwl:hasDbXref "PMID:15778510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001002 ; owl:annotatedTarget "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001002 ; owl:annotatedTarget "CD19" . [] oboInOwl:hasDbXref "PMID:16720896", "PMID:8983065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001003 ; owl:annotatedTarget "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001003 ; owl:annotatedTarget "CD34" . [] oboInOwl:hasDbXref "PMID:15326605" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001004 ; owl:annotatedTarget "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001004 ; owl:annotatedTarget "CD4" . [] oboInOwl:hasDbXref "PIRSF:PIRSF002497" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001005 ; owl:annotatedTarget "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" . [] oboInOwl:hasDbXref "PMID:1351092", "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001006 ; owl:annotatedTarget "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001006 ; owl:annotatedTarget "T200" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001006 ; owl:annotatedTarget "PTPRC" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001006 ; owl:annotatedTarget "CD45" . [] oboInOwl:hasDbXref "UniProtKB:P11215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001012 ; owl:annotatedTarget "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001012 ; owl:annotatedTarget "ITGAM" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001012 ; owl:annotatedTarget "CD11B" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001012 ; owl:annotatedTarget "CR3A" . [] oboInOwl:hasDbXref "UniProtKB:P20702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001013 ; owl:annotatedTarget "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001013 ; owl:annotatedTarget "ITGAX" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001013 ; owl:annotatedTarget "CD11C" . [] oboInOwl:hasDbXref "PMID:1351092", "PRO:CNA", "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001014 ; owl:annotatedTarget "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001014 ; owl:annotatedTarget "PTPRC/iso:CD45RABC" . [] oboInOwl:hasDbXref "PMID:1351092", "PRO:CNA", "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001015 ; owl:annotatedTarget "A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001015 ; owl:annotatedTarget "PTPRC/iso:CD45RA" . [] oboInOwl:hasDbXref "PMID:16473826", "PMID:1724736" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001018 ; owl:annotatedTarget "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001020 ; owl:annotatedTarget "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001020 ; owl:annotatedTarget "CD3E" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001020 ; owl:annotatedTarget "T3E" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001022 ; owl:annotatedTarget "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" . [] oboInOwl:hasDbXref "PMID:17975827" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001023 ; owl:annotatedTarget "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001024 ; owl:annotatedTarget "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001024 ; owl:annotatedTarget "NCAM1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001024 ; owl:annotatedTarget "NCAM" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001083 ; owl:annotatedTarget "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001083 ; owl:annotatedTarget "CD2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001083 ; owl:annotatedTarget "SRBC" . [] oboInOwl:hasDbXref "PMID:11114424", "PRO:CNA", "Wikipedia:CD8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001084 ; owl:annotatedTarget "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001084 ; owl:annotatedTarget "CD8A" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001084 ; owl:annotatedTarget "Lyt-2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001084 ; owl:annotatedTarget "Lyt2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001084 ; owl:annotatedTarget "MAL" . [] oboInOwl:hasDbXref "PRO:CNA", "Wikipedia:CD8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "CD8B" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "CD8B1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "Ly-3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "Lyt-3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001085 ; owl:annotatedTarget "Lyt3" . [] oboInOwl:hasDbXref "PMID:12761335", "PRO:DAN", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001087 ; owl:annotatedTarget "A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs." . [] oboInOwl:hasDbXref "IUPHARfam:17" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001087 ; owl:annotatedTarget "adhesion class GPCR" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:16884313" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001087 ; owl:annotatedTarget "fam:adhesion" . [] oboInOwl:hasDbXref "PMID:11790261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001087 ; owl:annotatedTarget "subfamily B2 G-protein coupled receptor" . [] oboInOwl:hasDbXref "PMID:12761335", "PRO:DAN", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001094 ; owl:annotatedTarget "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." . [] oboInOwl:hasDbXref "PMID:15914470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001094 ; owl:annotatedTarget "class 1 G-protein coupled receptor" . [] oboInOwl:hasDbXref "IUPHAR:GPCRListForward?class=A" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001094 ; owl:annotatedTarget "class A G-protein coupled receptor" . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001094 ; owl:annotatedTarget "fam:rhodopsin" . [] oboInOwl:hasDbXref "PMID:12037138", "PRO:WCB", "PRO:XQ" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001128 ; owl:annotatedTarget "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines." . [] oboInOwl:hasDbXref "PRO:DAN", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001197 ; owl:annotatedTarget "A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof." . [] oboInOwl:hasDbXref "PMID:12037138", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001199 ; owl:annotatedTarget "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001199 ; owl:annotatedTarget "CCR2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* inhibitor" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001199 ; owl:annotatedTarget "CMKBR2" . [] oboInOwl:hasDbXref "PMID:12037138", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "CCR7" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "CMKBR7" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "EBI1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "EVI1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001203 ; owl:annotatedTarget "Ebi1h" . [] oboInOwl:hasDbXref "PMID:12037138", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001206 ; owl:annotatedTarget "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001206 ; owl:annotatedTarget "CX3CR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001206 ; owl:annotatedTarget "CMKBRL1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76764 ; owl:annotatedTarget "EC 3.5.* inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001206 ; owl:annotatedTarget "GPR13" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001254 ; owl:annotatedTarget "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001254 ; owl:annotatedTarget "CCR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001254 ; owl:annotatedTarget "CMKBR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001254 ; owl:annotatedTarget "CMKR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001254 ; owl:annotatedTarget "SCYAR1" . [] oboInOwl:hasDbXref "PMID:12037138", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001255 ; owl:annotatedTarget "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001255 ; owl:annotatedTarget "CCR3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001255 ; owl:annotatedTarget "CMKBR3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001255 ; owl:annotatedTarget "Cmkbr1l2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76773 ; owl:annotatedTarget "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001281 ; owl:annotatedTarget "A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267)." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001289 ; owl:annotatedTarget "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001289 ; owl:annotatedTarget "MS4A1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001289 ; owl:annotatedTarget "CD20" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001289 ; owl:annotatedTarget "Ly-44" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001289 ; owl:annotatedTarget "Ms4a2" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001293 ; owl:annotatedTarget "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001293 ; owl:annotatedTarget "CD207" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001293 ; owl:annotatedTarget "CLEC4K" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76773 ; owl:annotatedTarget "EC 3.1.1.* inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "CD44" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "LHR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "MDU2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "MDU3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001307 ; owl:annotatedTarget "MIC4" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001308 ; owl:annotatedTarget "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001308 ; owl:annotatedTarget "CD48" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001308 ; owl:annotatedTarget "BCM1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001308 ; owl:annotatedTarget "BLAST1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001308 ; owl:annotatedTarget "Bcm-1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76773 ; owl:annotatedTarget "EC 3.1.1.* inhibitors" . [] oboInOwl:hasDbXref "PMID:12403782", "PRO:JAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001318 ; owl:annotatedTarget "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001318 ; owl:annotatedTarget "SELL" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001318 ; owl:annotatedTarget "LNHR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001318 ; owl:annotatedTarget "LYAM1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001318 ; owl:annotatedTarget "Ly22" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001327 ; owl:annotatedTarget "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001332 ; owl:annotatedTarget "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001332 ; owl:annotatedTarget "CEACAM8" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001332 ; owl:annotatedTarget "CGM6" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001338 ; owl:annotatedTarget "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76773 ; owl:annotatedTarget "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001338 ; owl:annotatedTarget "CR2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001338 ; owl:annotatedTarget "C3DR" . [] oboInOwl:hasDbXref "PMID:10466080", "PRO:CNA", "UniProtKB:Q07108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001343 ; owl:annotatedTarget "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001343 ; owl:annotatedTarget "CD69" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001343 ; owl:annotatedTarget "CLEC2C" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001344 ; owl:annotatedTarget "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001344 ; owl:annotatedTarget "ENPP3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001344 ; owl:annotatedTarget "PDNP3" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001345 ; owl:annotatedTarget "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001345 ; owl:annotatedTarget "ENG" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76773 ; owl:annotatedTarget "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001345 ; owl:annotatedTarget "END" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001345 ; owl:annotatedTarget "Edg" . [] oboInOwl:hasDbXref "InterPro:IPR001195", "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001352 ; owl:annotatedTarget "A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001355 ; owl:annotatedTarget "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001380 ; owl:annotatedTarget "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001380 ; owl:annotatedTarget "p55" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001380 ; owl:annotatedTarget "IL2RA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001380 ; owl:annotatedTarget "Il2r" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001381 ; owl:annotatedTarget "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001381 ; owl:annotatedTarget "p75" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76807 ; owl:annotatedTarget "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001381 ; owl:annotatedTarget "IL2RB" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001381 ; owl:annotatedTarget "IL15RB" . [] oboInOwl:hasDbXref "PRO:WCB", "Wikipedia:Tetraspanin" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001403 ; owl:annotatedTarget "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001408 ; owl:annotatedTarget "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001408 ; owl:annotatedTarget "CD38" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001444 ; owl:annotatedTarget "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001444 ; owl:annotatedTarget "CDH5" . [] oboInOwl:hasDbXref "InterPro:IPR001195", "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001460 ; owl:annotatedTarget "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001460 ; owl:annotatedTarget "GYPA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001460 ; owl:annotatedTarget "GPA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76807 ; owl:annotatedTarget "EC 3.5.1.* inhibitor" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001479 ; owl:annotatedTarget "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001479 ; owl:annotatedTarget "CD32" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001479 ; owl:annotatedTarget "Fcgr2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001479 ; owl:annotatedTarget "Fcgr2b" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "CD32" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "CDw32" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "FCGR2B" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "FCG2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001481 ; owl:annotatedTarget "IGFR2" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76807 ; owl:annotatedTarget "EC 3.5.1.* inhibitors" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001483 ; owl:annotatedTarget "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001483 ; owl:annotatedTarget "Fcgr3" . [] oboInOwl:hasDbXref "InterPro:IPR008795", "PMID:11467842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001785 ; owl:annotatedTarget "A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001786 ; owl:annotatedTarget "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001786 ; owl:annotatedTarget "PROM1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001786 ; owl:annotatedTarget "MSTP061" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001786 ; owl:annotatedTarget "PROML1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001786 ; owl:annotatedTarget "Prom" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001809 ; owl:annotatedTarget "A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001809 ; owl:annotatedTarget "CD59-like" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76807 ; owl:annotatedTarget "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001810 ; owl:annotatedTarget "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." . [] oboInOwl:hasDbXref "PRO:DAN", "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001813 ; owl:annotatedTarget "An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001813 ; owl:annotatedTarget "ADGRE1" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001813 ; owl:annotatedTarget "EMR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001813 ; owl:annotatedTarget "Gpf480" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001813 ; owl:annotatedTarget "TM7LN3" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001832 ; owl:annotatedTarget "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001833 ; owl:annotatedTarget "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001833 ; owl:annotatedTarget "SLAMF1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001833 ; owl:annotatedTarget "SLAM" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76807 ; owl:annotatedTarget "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001836 ; owl:annotatedTarget "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001836 ; owl:annotatedTarget "CD7" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001839 ; owl:annotatedTarget "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001839 ; owl:annotatedTarget "CD5" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001839 ; owl:annotatedTarget "LEU1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001843 ; owl:annotatedTarget "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001843 ; owl:annotatedTarget "THY1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001843 ; owl:annotatedTarget "Thy-1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001858 ; owl:annotatedTarget "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001858 ; owl:annotatedTarget "VPREB1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76823 ; owl:annotatedTarget "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001858 ; owl:annotatedTarget "VPREB" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001859 ; owl:annotatedTarget "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001859 ; owl:annotatedTarget "IGLL1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001859 ; owl:annotatedTarget "IGL1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001861 ; owl:annotatedTarget "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725)." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001865 ; owl:annotatedTarget "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001865 ; owl:annotatedTarget "IL3RA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001865 ; owl:annotatedTarget "IL3R" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001865 ; owl:annotatedTarget "Sut-1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001867 ; owl:annotatedTarget "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76823 ; owl:annotatedTarget "EC 6.3.1.* inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001867 ; owl:annotatedTarget "IL5RA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001867 ; owl:annotatedTarget "IL5R" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001869 ; owl:annotatedTarget "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001869 ; owl:annotatedTarget "IL7R" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001874 ; owl:annotatedTarget "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001879 ; owl:annotatedTarget "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001879 ; owl:annotatedTarget "SPN" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001879 ; owl:annotatedTarget "CD43" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "FCER2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76823 ; owl:annotatedTarget "EC 6.3.1.* inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "CD23A" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "CLEC4J" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "FCE2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "Fcer2a" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001880 ; owl:annotatedTarget "IGEBF" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001883 ; owl:annotatedTarget "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001888 ; owl:annotatedTarget "A protein with core architecture consisting of a Peptidase family M1 domain (Pfam:PF01433)." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001889 ; owl:annotatedTarget "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001889 ; owl:annotatedTarget "CD14" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001892 ; owl:annotatedTarget "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76823 ; owl:annotatedTarget "acid-ammonia (or amine) ligase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001892 ; owl:annotatedTarget "CD33" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001892 ; owl:annotatedTarget "SIGLEC3" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001896 ; owl:annotatedTarget "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001896 ; owl:annotatedTarget "CD244" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001896 ; owl:annotatedTarget "2B4" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001896 ; owl:annotatedTarget "Nmrk" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001898 ; owl:annotatedTarget "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001898 ; owl:annotatedTarget "MME" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001898 ; owl:annotatedTarget "EPN" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001903 ; owl:annotatedTarget "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76823 ; owl:annotatedTarget "acid-ammonia (or amine) ligase inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001903 ; owl:annotatedTarget "PAX5" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001903 ; owl:annotatedTarget "Pax-5" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001919 ; owl:annotatedTarget "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001919 ; owl:annotatedTarget "PDCD1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001919 ; owl:annotatedTarget "PD1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001925 ; owl:annotatedTarget "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001925 ; owl:annotatedTarget "CD163" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001925 ; owl:annotatedTarget "M130" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001932 ; owl:annotatedTarget "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001932 ; owl:annotatedTarget "CD24" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* (C-C bond forming ligase) inhibitor" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001932 ; owl:annotatedTarget "CD24A" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001935 ; owl:annotatedTarget "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001935 ; owl:annotatedTarget "SDC1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001935 ; owl:annotatedTarget "SDC" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001935 ; owl:annotatedTarget "Synd-1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001938 ; owl:annotatedTarget "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001944 ; owl:annotatedTarget "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001944 ; owl:annotatedTarget "SPI1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001944 ; owl:annotatedTarget "Sfpi-1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001944 ; owl:annotatedTarget "Sfpi1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* (C-C bond forming ligase) inhibitors" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001945 ; owl:annotatedTarget "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001945 ; owl:annotatedTarget "p90" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001945 ; owl:annotatedTarget "TFRC" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001945 ; owl:annotatedTarget "Trfr" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001950 ; owl:annotatedTarget "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001950 ; owl:annotatedTarget "TRAP" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001950 ; owl:annotatedTarget "CD40LG" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001950 ; owl:annotatedTarget "CD40L" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001950 ; owl:annotatedTarget "TNFSF5" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001963 ; owl:annotatedTarget "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:17502136" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* (C-C bond-forming ligase) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001963 ; owl:annotatedTarget "CD27" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001963 ; owl:annotatedTarget "TNFRSF7" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "p84" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "SIRPA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "BIT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "MFR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "MYD1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "PTPNS1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "SHPS1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* (carboxylase) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001968 ; owl:annotatedTarget "SIRP" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001969 ; owl:annotatedTarget "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000001969 ; owl:annotatedTarget "PLAUR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001969 ; owl:annotatedTarget "MO3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000001969 ; owl:annotatedTarget "UPAR" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000001971 ; owl:annotatedTarget "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002001 ; owl:annotatedTarget "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002001 ; owl:annotatedTarget "FLT3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002001 ; owl:annotatedTarget "CD135" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002001 ; owl:annotatedTarget "FLK2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* inhibitor" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002001 ; owl:annotatedTarget "STK1" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "CD93" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "Aa4" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "C1QR1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "Ly68" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002037 ; owl:annotatedTarget "MXRA4" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002039 ; owl:annotatedTarget "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002039 ; owl:annotatedTarget "ENPEP" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002062 ; owl:annotatedTarget "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "EC 6.4.1.* inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002062 ; owl:annotatedTarget "CSF1R" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002062 ; owl:annotatedTarget "Csfmr" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002062 ; owl:annotatedTarget "FMS" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002064 ; owl:annotatedTarget "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002064 ; owl:annotatedTarget "CD68" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002065 ; owl:annotatedTarget "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002065 ; owl:annotatedTarget "KIT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002065 ; owl:annotatedTarget "SCFR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002065 ; owl:annotatedTarget "Sl" . [] oboInOwl:hasDbXref "PRO:WCB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002112 ; owl:annotatedTarget "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "inhibitor of ligases forming C-C bonds" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002112 ; owl:annotatedTarget "KDR" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002112 ; owl:annotatedTarget "FLK1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002112 ; owl:annotatedTarget "VEGFR2" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002976 ; owl:annotatedTarget "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002977 ; owl:annotatedTarget "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002977 ; owl:annotatedTarget "Klrb1c" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002977 ; owl:annotatedTarget "Ly55c" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002977 ; owl:annotatedTarget "Nkrp1c" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002978 ; owl:annotatedTarget "An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002978 ; owl:annotatedTarget "Ly6g" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "inhibitor of ligases forming C-C bonds (EC 6.4.1.*)" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002979 ; owl:annotatedTarget "An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002979 ; owl:annotatedTarget "Ly6a" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002979 ; owl:annotatedTarget "Ly6" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002980 ; owl:annotatedTarget "An Ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002980 ; owl:annotatedTarget "Ly6c2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000002980 ; owl:annotatedTarget "Ly6c" . [] oboInOwl:hasDbXref "PMID:10848813", "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000002981 ; owl:annotatedTarget "A protein that is a translation product of the Ly76 gene in mouse." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000002981 ; owl:annotatedTarget "mLy76" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003457 ; owl:annotatedTarget "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003457 ; owl:annotatedTarget "RAG1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "inhibitors of ligases forming C-C bonds" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003457 ; owl:annotatedTarget "RNF74" . [] oboInOwl:hasDbXref "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003460 ; owl:annotatedTarget "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003460 ; owl:annotatedTarget "RAG2" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003516 ; owl:annotatedTarget "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000003516 ; owl:annotatedTarget "alpha-1,4-N-acetylglucosaminyltransferase" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003516 ; owl:annotatedTarget "A4GALT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003516 ; owl:annotatedTarget "A14GALT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003516 ; owl:annotatedTarget "A4GALT1" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "ADIPOQ" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76824 ; owl:annotatedTarget "inhibitors of ligases forming C-C bonds (EC 6.4.1.*)" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "ACDC" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "ACRP30" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "APM1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003777 ; owl:annotatedTarget "GBP28" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003809 ; owl:annotatedTarget "A protein that is a translation product of the human AFP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003809 ; owl:annotatedTarget "AFP" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003809 ; owl:annotatedTarget "HPAFP" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "ALB" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "Alb-1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76835 ; owl:annotatedTarget "EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "Alb1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "GIG20" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "GIG42" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "PRO0903" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "PRO1708" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "PRO2044" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "PRO2619" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "PRO2675" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003918 ; owl:annotatedTarget "UNQ696/PRO1341" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003964 ; owl:annotatedTarget "A protein that is a translation product of the human ALPI gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76835 ; owl:annotatedTarget "EC 1.1.1.* inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003964 ; owl:annotatedTarget "ALPI" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003968 ; owl:annotatedTarget "A protein that is a translation product of the human ALPL gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003968 ; owl:annotatedTarget "ALPL" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003968 ; owl:annotatedTarget "Akp-2" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003968 ; owl:annotatedTarget "Akp2" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000003969 ; owl:annotatedTarget "A protein that is a translation product of the human ALPP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000003969 ; owl:annotatedTarget "ALPP" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000003969 ; owl:annotatedTarget "PLAP" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000004089 ; owl:annotatedTarget "A protein that is a translation product of the human AOX1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000004089 ; owl:annotatedTarget "AOX1" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:20001317" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76835 ; owl:annotatedTarget "EC 1.1.1.* inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000004089 ; owl:annotatedTarget "AO" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000004089 ; owl:annotatedTarget "Ro" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000005061 ; owl:annotatedTarget "A protein that is a translation product of the human CAT gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000005061 ; owl:annotatedTarget "CAT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005061 ; owl:annotatedTarget "Cas-1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005061 ; owl:annotatedTarget "Cas1" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "p24" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "CD9" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "GIG2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76835 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "MIC3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005178 ; owl:annotatedTarget "TSPAN29" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000005307 ; owl:annotatedTarget "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000005307 ; owl:annotatedTarget "CEBPA" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000005307 ; owl:annotatedTarget "CEBP" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000005794 ; owl:annotatedTarget "A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000005794 ; owl:annotatedTarget "CP" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000006169 ; owl:annotatedTarget "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000006169 ; owl:annotatedTarget "Cd200r3" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000006611 ; owl:annotatedTarget "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76835 ; owl:annotatedTarget "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000006611 ; owl:annotatedTarget "DNTT" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000006611 ; owl:annotatedTarget "TDT" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000006678 ; owl:annotatedTarget "A protein that is a translation product of the human DPYD gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000006678 ; owl:annotatedTarget "DPD" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000006678 ; owl:annotatedTarget "dihydrothymine dehydrogenase" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000006678 ; owl:annotatedTarget "dihydrouracil dehydrogenase" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000006678 ; owl:annotatedTarget "DPYD" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007431 ; owl:annotatedTarget "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007431 ; owl:annotatedTarget "FCER1A" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007431 ; owl:annotatedTarget "FCE1A" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76874 ; owl:annotatedTarget "EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007499 ; owl:annotatedTarget "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007499 ; owl:annotatedTarget "FGF8" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007499 ; owl:annotatedTarget "AIGF" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "A protein that is a translation product of the human FOXN1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "FOXN1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "Fkh19" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "Hfh11" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "RONU" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007636 ; owl:annotatedTarget "WHN" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007749 ; owl:annotatedTarget "A glucose-6-phosphate dehydrogenase that is a translation product of the human G6PD gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76874 ; owl:annotatedTarget "EC 2.1.2.* inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007749 ; owl:annotatedTarget "G6PD" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007749 ; owl:annotatedTarget "G6pd-1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007749 ; owl:annotatedTarget "G6pdx" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007812 ; owl:annotatedTarget "A protein that is a translation product of the human GALE gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007812 ; owl:annotatedTarget "GALE" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007856 ; owl:annotatedTarget "A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007856 ; owl:annotatedTarget "GAST" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007856 ; owl:annotatedTarget "GAS" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007857 ; owl:annotatedTarget "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007857 ; owl:annotatedTarget "GATA1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76874 ; owl:annotatedTarget "EC 2.1.2.* inhibitors" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007857 ; owl:annotatedTarget "ERYF1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007857 ; owl:annotatedTarget "GF1" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007858 ; owl:annotatedTarget "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007858 ; owl:annotatedTarget "GATA2" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007891 ; owl:annotatedTarget "A protein that is a translation product of the human GCG gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007891 ; owl:annotatedTarget "GCG" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007939 ; owl:annotatedTarget "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007939 ; owl:annotatedTarget "GFAP" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000007975 ; owl:annotatedTarget "A protein that is a translation product of the human CBLIF gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000007975 ; owl:annotatedTarget "CBLIF" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76874 ; owl:annotatedTarget "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitor" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007975 ; owl:annotatedTarget "GIF" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000007975 ; owl:annotatedTarget "IFMH" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000008175 ; owl:annotatedTarget "A protein that is a translation product of the human GPI gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000008175 ; owl:annotatedTarget "NLK" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000008175 ; owl:annotatedTarget "GPI" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000008175 ; owl:annotatedTarget "Gpi1" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000008730 ; owl:annotatedTarget "A protein that is a translation product of the human HPD gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000008730 ; owl:annotatedTarget "HPD" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000008730 ; owl:annotatedTarget "PPD" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000008894 ; owl:annotatedTarget "A protein that is a translation product of the human IDS gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76874 ; owl:annotatedTarget "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000008894 ; owl:annotatedTarget "IDS" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000008894 ; owl:annotatedTarget "SIDS" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009054 ; owl:annotatedTarget "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000009054 ; owl:annotatedTarget "insulin" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009054 ; owl:annotatedTarget "INS" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009127 ; owl:annotatedTarget "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009127 ; owl:annotatedTarget "ITGA2B" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009127 ; owl:annotatedTarget "GP2B" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009127 ; owl:annotatedTarget "ITGAB" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009143 ; owl:annotatedTarget "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76924 ; owl:annotatedTarget "plant metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009143 ; owl:annotatedTarget "ITGB7" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009758 ; owl:annotatedTarget "A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009758 ; owl:annotatedTarget "LEP" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009758 ; owl:annotatedTarget "OB" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009758 ; owl:annotatedTarget "OBS" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009771 ; owl:annotatedTarget "A protein that is a translation product of the human LGALS3 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009771 ; owl:annotatedTarget "LGALS3" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009771 ; owl:annotatedTarget "MAC2" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000009978 ; owl:annotatedTarget "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000009978 ; owl:annotatedTarget "LTF" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76924 ; owl:annotatedTarget "plant secondary metabolites" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009978 ; owl:annotatedTarget "GIG12" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000009978 ; owl:annotatedTarget "LF" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000010379 ; owl:annotatedTarget "A protein that is a translation product of the human MGAT2 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000010379 ; owl:annotatedTarget "MGAT2" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000011649 ; owl:annotatedTarget "A protein that is a translation product of the human OPLAH gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000011649 ; owl:annotatedTarget "OPLAH" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000012234 ; owl:annotatedTarget "A protein that is a translation product of the human PAH gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000012234 ; owl:annotatedTarget "PAH" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000013246 ; owl:annotatedTarget "A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000013246 ; owl:annotatedTarget "PRL" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000013429 ; owl:annotatedTarget "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000013429 ; owl:annotatedTarget "PTH" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000013883 ; owl:annotatedTarget "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000013883 ; owl:annotatedTarget "REN" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000014841 ; owl:annotatedTarget "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000014841 ; owl:annotatedTarget "SHH" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000014841 ; owl:annotatedTarget "Hhg1" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000016043 ; owl:annotatedTarget "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000016043 ; owl:annotatedTarget "TAL1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000016043 ; owl:annotatedTarget "BHLHA17" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76928 ; owl:annotatedTarget "a 2,3-saturated fatty acid" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000016043 ; owl:annotatedTarget "SCL" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000016043 ; owl:annotatedTarget "TCL5" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000016401 ; owl:annotatedTarget "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000016401 ; owl:annotatedTarget "TMED1" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000016401 ; owl:annotatedTarget "IL1RL1L" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000016401 ; owl:annotatedTarget "IL1RL1LG" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000017364 ; owl:annotatedTarget "A protein that is a translation product of the human VWF gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000017364 ; owl:annotatedTarget "VWF" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000017364 ; owl:annotatedTarget "F8VWF" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000017477 ; owl:annotatedTarget "A protein that is a translation product of the human XDH gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000017477 ; owl:annotatedTarget "XDH" . [] oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_000017477 ; owl:annotatedTarget "XDHA" . [] oboInOwl:hasDbXref "PRO:DAN", "PRO:JSG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018263 ; owl:annotatedTarget "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000018263 ; owl:annotatedTarget "peptide" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000018263 ; owl:annotatedTarget "polypeptide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76932 ; owl:annotatedTarget "metabolic pathway inhibitor" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018264 ; owl:annotatedTarget "A protein that is produced as the result of proteolytic processing of a longer protein." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018264 ; owl:annotatedTarget "ClvPrd" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000018264 ; owl:annotatedTarget "peptide" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000018264 ; owl:annotatedTarget "polypeptide" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018335 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018335 ; owl:annotatedTarget "CD8A/SigPep-" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018337 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018337 ; owl:annotatedTarget "CD8B/SigPep-" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76932 ; owl:annotatedTarget "metabolic pathway inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018381 ; owl:annotatedTarget "A CD48 molecule that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018381 ; owl:annotatedTarget "CD48/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76932 ; owl:annotatedTarget "pathway inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018390 ; owl:annotatedTarget "An L-selectin that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018390 ; owl:annotatedTarget "SELL/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018406 ; owl:annotatedTarget "A carcinoembryonic antigen-related cell adhesion molecule 8 that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018406 ; owl:annotatedTarget "CEACAM8/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76946 ; owl:annotatedTarget "fungal metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018546 ; owl:annotatedTarget "A Thy-1 membrane glycoprotein that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018546 ; owl:annotatedTarget "THY1/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76956 ; owl:annotatedTarget "Aspergillus metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018568 ; owl:annotatedTarget "A low affinity immunoglobulin epsilon Fc receptor that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018568 ; owl:annotatedTarget "FCER2/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018594 ; owl:annotatedTarget "A scavenger receptor cysteine-rich type 1 protein M130 that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76967 ; owl:annotatedTarget "human xenobiotic metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018594 ; owl:annotatedTarget "CD163/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018603 ; owl:annotatedTarget "A transferrin receptor protein 1 that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018603 ; owl:annotatedTarget "TFRC/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76971 ; owl:annotatedTarget "E.coli metabolite" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018606 ; owl:annotatedTarget "A tumor necrosis factor ligand superfamily member 5 that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018606 ; owl:annotatedTarget "CD40LG/ClvPrd" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:25584012" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76971 ; owl:annotatedTarget "E.coli metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018950 ; owl:annotatedTarget "An albumin that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018950 ; owl:annotatedTarget "ALB/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000018969 ; owl:annotatedTarget "An alkaline phosphatase, placental type that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000018969 ; owl:annotatedTarget "ALPP/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_76971 ; owl:annotatedTarget "Escherichia coli metabolites" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000019705 ; owl:annotatedTarget "A dihydropyrimidine dehydrogenase [NADP(+)] that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000019705 ; owl:annotatedTarget "DPYD/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000019973 ; owl:annotatedTarget "A gastrin that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000019973 ; owl:annotatedTarget "GAST/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000019980 ; owl:annotatedTarget "A pro-glucagon that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000019980 ; owl:annotatedTarget "GCG/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000020230 ; owl:annotatedTarget "An iduronate 2-sulfatase that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000020230 ; owl:annotatedTarget "IDS/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "9-keto-prostaglandin E2 reductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000020329 ; owl:annotatedTarget "An integrin alpha-IIb that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000020329 ; owl:annotatedTarget "ITGA2B/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000020497 ; owl:annotatedTarget "A lactotransferrin that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "9-keto-prostaglandin E2 reductase inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000020497 ; owl:annotatedTarget "LTF/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000021170 ; owl:annotatedTarget "A parathyroid hormone that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000021170 ; owl:annotatedTarget "PTH/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "9-ketoprostaglandin reductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000021468 ; owl:annotatedTarget "A sonic hedgehog protein that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000021468 ; owl:annotatedTarget "SHH/ClvPrd" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "9-ketoprostaglandin reductase inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000021841 ; owl:annotatedTarget "A von Willebrand factor that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000021841 ; owl:annotatedTarget "VWF/ClvPrd" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000023661 ; owl:annotatedTarget "A protein that is a translation product of the Escherichia coli K-12 pyrF gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000023661 ; owl:annotatedTarget "pyrF" . [] oboInOwl:hasDbXref "PMID:18275828", "PMID:3264320", "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025402 ; owl:annotatedTarget "A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025403 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025403 ; owl:annotatedTarget "CD8A/iso:1" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025405 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025405 ; owl:annotatedTarget "CD8B/iso:1" . [] oboInOwl:hasDbXref "PMID:1541829" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025405 ; owl:annotatedTarget "CD8beta isoform M-1" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025406 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025406 ; owl:annotatedTarget "CD8A/iso:1/SigPep-" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025407 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025407 ; owl:annotatedTarget "CD8B/iso:1/SigPep-" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025408 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025408 ; owl:annotatedTarget "CD8A/iso:1/SigPep-/GlycoRes+" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025409 ; owl:annotatedTarget "A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025409 ; owl:annotatedTarget "CD8B/iso:1/SigPep-/GlycoRes+" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "EC 1.1.1.189 inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025455 ; owl:annotatedTarget "A CD2 molecule that has been processed by proteolytic cleavage." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025455 ; owl:annotatedTarget "CD2/ClvPrd" . [] oboInOwl:hasDbXref "PMID:19693543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025796 ; owl:annotatedTarget "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000025797 ; owl:annotatedTarget "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000025797 ; owl:annotatedTarget "fam:ITGAsansA" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PMID:28600633" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "EC 1.1.1.189 inhibitors" . [] oboInOwl:hasDbXref "MGI:2151253", "PRO:CNA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000027222 ; owl:annotatedTarget "A protein that is a translation product of the human CALCA gene or a 1:1 ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000027222 ; owl:annotatedTarget "CALCA" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000028527 ; owl:annotatedTarget "A proteolytic cleavage product that is derived from any of the casein milk proteins." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000028527 ; owl:annotatedTarget "CN (f)" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000029032 ; owl:annotatedTarget "A protein that is encoded in the genome of Mus musculus." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000029032 ; owl:annotatedTarget "mouse protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000029067 ; owl:annotatedTarget "A protein that is encoded in the genome of Homo sapiens." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000029067 ; owl:annotatedTarget "human protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000029968 ; owl:annotatedTarget "A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000029968 ; owl:annotatedTarget "fam:GH1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE-9-ketoreductase inhibitor" . [] oboInOwl:hasDbXref "IUPHARfam:694", "PRO:DAN", "Wikipedia:GPCR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000030035 ; owl:annotatedTarget "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." . [] oboInOwl:hasDbXref "IUPHARfam:694" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000030035 ; owl:annotatedTarget "7TM receptor" . [] oboInOwl:hasDbXref "IUPHARfam:694" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:PR_000030035 ; owl:annotatedTarget "seven-transmembrane receptor" . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000030035 ; owl:annotatedTarget "fam:GPCR" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000036194 ; owl:annotatedTarget "A protein that is encoded in the genome of some Eukaryota." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE-9-ketoreductase inhibitors" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000036194 ; owl:annotatedTarget "Eukaryota protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000037069 ; owl:annotatedTarget "A protein that includes at least one glycosylated residue." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000037069 ; owl:annotatedTarget "Prot/GlycoRes+" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000037069 ; owl:annotatedTarget "glycated protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000037069 ; owl:annotatedTarget "glycosylated protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000045358 ; owl:annotatedTarget "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000045358 ; owl:annotatedTarget "fam:INS" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2 9-oxoreductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000049995 ; owl:annotatedTarget "A protein that has alpha-amylase activity." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000049995 ; owl:annotatedTarget "fam:AMY" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000049996 ; owl:annotatedTarget "An active alpha-amylase isozyme that is encoded in the genome of human." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000049996 ; owl:annotatedTarget "fam:hAMY" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000050025 ; owl:annotatedTarget "A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000050025 ; owl:annotatedTarget "fam:angiotensinogenase" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000050060 ; owl:annotatedTarget "A protein that contains a single copy of the Glucose-6-phosphate dehydrogenase, NAD binding domain (Pfam:PF00479) at or near the N terminus, a single copy of the Glucose-6-phosphate dehydrogenase, C-terminal domain (Pfam:PF02781) at or near the C terminus, and no other domains." . [] oboInOwl:hasDbXref "PRO:DAN" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000050060 ; owl:annotatedTarget "fam:G6PD" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2 9-oxoreductase inhibitors" . [] oboInOwl:hasDbXref "GOC:add", "PRO:ADD", "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000050216 ; owl:annotatedTarget "A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A)." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_000050216 ; owl:annotatedTarget "PTPRC/iso:CD45R" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_000050567 ; owl:annotatedTarget "A material entity that minimally consists of a protein." . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000050567 ; owl:annotatedTarget "protein" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000050567 ; owl:annotatedTarget "protein aggregate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2-9-OR inhibitor" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000050567 ; owl:annotatedTarget "protein complex" . [] oboInOwl:hasDbXref "PRO:DAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:PR_000050567 ; owl:annotatedTarget "protein-containing complex" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:O14841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "A 5-oxoprolinase that is encoded in the genome of human." . [] a owl:Axiom ; rdfs:label "PR:O14841 located_in GO:0005829" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "Reactome:R-HSA-1247948" . [] oboInOwl:hasDbXref "UniProtKB:O14841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "5-OPase (human)" . [] oboInOwl:hasDbXref "UniProtKB:O14841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "5-oxo-L-prolinase (human)" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "hOPLAH" . [] oboInOwl:hasDbXref "UniProtKB:O14841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "pyroglutamase (human)" . [] oboInOwl:hasDbXref "UniProtKB:O14841" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_O14841 ; owl:annotatedTarget "OPLAH" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:P00450" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_P00450 ; owl:annotatedTarget "A ceruloplasmin that is encoded in the genome of human." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2-9-OR inhibitors" . [] oboInOwl:hasDbXref "UniProtKB:P00450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P00450 ; owl:annotatedTarget "ferroxidase (human)" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P00450 ; owl:annotatedTarget "hCP" . [] oboInOwl:hasDbXref "UniProtKB:P00450" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_P00450 ; owl:annotatedTarget "CP" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:P32754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human." . [] oboInOwl:hasDbXref "UniProtKB:P32754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "4-hydroxyphenylpyruvic acid oxidase (human)" . [] oboInOwl:hasDbXref "UniProtKB:P32754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "4HPPD (human)" . [] oboInOwl:hasDbXref "UniProtKB:P32754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "HPPDase (human)" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "hHPD" . [] oboInOwl:hasDbXref "UniProtKB:P32754" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "HPD" . [] oboInOwl:hasDbXref "UniProtKB:P32754" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_P32754 ; owl:annotatedTarget "PPD" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2-9-ketoreductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:P47989" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_P47989 ; owl:annotatedTarget "A xanthine dehydrogenase/oxidase that is encoded in the genome of human." . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_P47989 ; owl:annotatedTarget "hXDH" . [] oboInOwl:hasDbXref "UniProtKB:P47989" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_P47989 ; owl:annotatedTarget "XDH" . [] oboInOwl:hasDbXref "UniProtKB:P47989" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_P47989 ; owl:annotatedTarget "XDHA" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human." . [] a owl:Axiom ; rdfs:label "PR:Q10469 located_in GO:0000139" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "Reactome:R-HSA-975830" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "GNT-II (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "GlcNAc-T II (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "beta-1,2-N-acetylglucosaminyltransferase II (human)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "PGE2-9-ketoreductase inhibitors" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "hMGAT2" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "mannoside acetylglucosaminyltransferase 2 (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q10469" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q10469 ; owl:annotatedTarget "MGAT2" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:Q12882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human." . [] oboInOwl:hasDbXref "UniProtKB:Q12882" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "DHPDHase (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q12882" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "DPD (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q12882" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "dihydrothymine dehydrogenase (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q12882" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "dihydrouracil dehydrogenase (human)" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "hDPYD" . [] oboInOwl:hasDbXref "UniProtKB:Q12882" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q12882 ; owl:annotatedTarget "DPYD" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin 9-ketoreductase inhibitor" . [] oboInOwl:hasDbXref "PRO:DNx", "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "An adiponectin that is encoded in the genome of human." . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "30 kDa adipocyte complement-related protein (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "adipocyte complement-related 30 kDa protein (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "adipocyte, C1q and collagen domain-containing protein (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "adipose most abundant gene transcript 1 protein (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "apM-1 (human)" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "gelatin-binding protein (human)" . [] oboInOwl:hasDbXref "PRO:DNx" ; oboInOwl:hasSynonymType pr:PRO-short-label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "hADIPOQ" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "ACDC" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "ACRP30" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Reaxys:607489" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin 9-ketoreductase inhibitors" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "ADIPOQ" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "APM1" . [] oboInOwl:hasDbXref "UniProtKB:Q15848" ; oboInOwl:hasSynonymType pr:Gene-based ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:PR_Q15848 ; owl:annotatedTarget "GBP28" . [] oboInOwl:hasDbXref "span:ProcessualEntity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000000 ; owl:annotatedTarget "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin E 9-ketoreductase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Cervix", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "Lower, narrow portion of the uterus where it joins with the top end of the vagina." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001359" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/uterine+cervix" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001359" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1098/rspb.2004.2848 Lynch VJ, Roth JJ, Takahashi K, Dunn CW, Nonaka DF, Stopper GF, Wagner GP, Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals. Proceedings of the Royal Society of London, Series B (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG]" . [] oboInOwl:hasDbXref "EFO:0000979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "cervix" . [] oboInOwl:source "ncithesaurus:Cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "UMLS:C0007874" . [] oboInOwl:hasDbXref "FMA:17740", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "canalis cervicis uteri" . [] oboInOwl:hasDbXref "FMA:17740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "cervical canal of uterus" . [] oboInOwl:hasDbXref "EMAPA:29927" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "cervix uteri" . [] oboInOwl:hasDbXref "FMA:17740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "neck of uterus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin E 9-ketoreductase inhibitors" . [] oboInOwl:hasDbXref "FMA:17740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "uterine cervix" . [] oboInOwl:hasDbXref "FMA:17740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "cervical canal" . [] oboInOwl:hasDbXref "BTO:0001421" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000002 ; owl:annotatedTarget "cervix of uterus" . _:genid110827 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000033, obo:UBERON_0001707 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000003 ; owl:annotatedTarget _:genid110827 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin E2-9-oxoreductase inhibitor" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000003 ; owl:annotatedTarget "Orifice of the olfactory system. The naris is the route by which odorants enter the olfactory system[MAH]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000311" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000003 ; owl:annotatedTarget "One of paired external openings of the nasal chamber.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000663" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature02843 Zhu M, Ahlberg PE, The origin of the internal nostril in tetrapodes. Nature (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000003 ; owl:annotatedTarget "Naris refer to the external and interior naris (choana) of tetrapods, and to anterior and posterior naris of zebrafish. It seems now accepted that the structure is homologous: The choana, a unique 'internal nostril' opening from the nasal sac into the roof of the mouth, is a key part of the tetrapod (land vertebrate) respiratory system. It was the first component of the tetrapod body plan to evolve, well before the origin of limbs, and is therefore crucial to our understanding of the beginning of the fish-tetrapod transition. (...) Here we present new material of Kenichthys, a 395-million-year-old fossil fish from China, that provides direct evidence for the origin of the choana and establishes its homology: it is indeed a displaced posterior external nostril that, during a brief transitional stage illustrated by Kenichthys, separated the maxilla from the premaxilla.[well established][VHOG]" . _:genid110833 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000003 ; owl:annotatedTarget "we have classified this as an orifice, according to FMA. Note that in FMA, orifices are immaterial entities, but in ZFA this is a surface structure" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 . _:genid110835 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001004, obo:UBERON_0003050 . [] oboInOwl:source "FMA", "ZFA-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget _:genid110833 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget _:genid110835 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin E2-9-oxoreductase inhibitors" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity." . [] oboInOwl:source "ZFA:0000047" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047]." . [] oboInOwl:source "Wikipedia:Nose" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]." . [] oboInOwl:source "MP:0002233" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "the organ that is specialized for smell and is part of the respiratory system" . [] oboInOwl:source "ncithesaurus:Nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "UMLS:C0028429" . [] oboInOwl:hasDbXref "ZFA:0000047" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "nasal sac" . [] oboInOwl:hasDbXref "MA:0000281" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "nose" . [] oboInOwl:hasDbXref "ZFA:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "peripheral olfactory organ" . [] oboInOwl:hasDbXref "Wikipedia:Nose" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "nasus" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000004 ; owl:annotatedTarget "olfactory apparatus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitor" . [] oboInOwl:hasDbXref "FBbt:00005157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000005 ; owl:annotatedTarget "chemosensory sensory organ" . _:genid110859 oboInOwl:source "PMID:16417468" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget _:genid110859 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000168 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitors" . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget _:genid110861 . _:genid110861 oboInOwl:source "PMID:16417468" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget _:genid110863 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000172 . [] oboInOwl:hasDbXref "MA:0000127", "MESH:A03.734.414", "MP:0005215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "The clusters of hormone-producing cells that are scattered throughout the pancreas." . _:genid110863 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010406" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002067 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000646" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" . [] oboInOwl:source "ncithesaurus:Islet_of_Langerhans" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "UMLS:C0022131" . [] oboInOwl:hasDbXref "BTO:0000991" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "island of Langerhans" . [] oboInOwl:hasDbXref "BTO:0000991" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000006 ; owl:annotatedTarget "island of pancreas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "reductase, 15-hydroxy-9-oxoprostaglandin inhibitor" . [] oboInOwl:source "BTO", "EFO", "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget obo:UBERON_0002368 . _:genid110874 oboInOwl:source "MA", "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget _:genid110874 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget _:genid110876 . _:genid110876 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget _:genid110878 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000440 . [] oboInOwl:source "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget _:genid110884 . _:genid110878 oboInOwl:hasDbXref "Wikipedia:Pituitary_gland", "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000642 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010536" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "An endocrine gland derived from infundibulum of the floor of the diencephalon and an ectodermal dorsal protrusion from the buccal cavity which controls the secretion of many hormones influencing the function of various organs of the body.[AAO]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77119 ; owl:annotatedTarget "reductase, 15-hydroxy-9-oxoprostaglandin inhibitors" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000118" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000143" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1353", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "Hp" . [] oboInOwl:source "BIRNLEX:1353", "ncithesaurus:Pituitary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "UMLS:C0032005" . _:genid110884 oboInOwl:source "BIRNLEX:1353" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "neuronames:399" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0034875 . [] oboInOwl:hasDbXref "Wikipedia:Pituitary_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "glandula pituitaria" . [] oboInOwl:hasDbXref "BTO:0001073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "pituitary" . [] oboInOwl:hasDbXref "BTO:0001073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "pituitary body" . [] oboInOwl:hasDbXref "ZFA:0000118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "hypophysis" . [] oboInOwl:hasDbXref "MA:0000176" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000007 ; owl:annotatedTarget "hypophysis cerebri" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77182 ; owl:annotatedTarget "food coloring" . [] oboInOwl:hasDbXref "Wikipedia:Submucosa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "UMLS:C0225344" . [] oboInOwl:hasDbXref "FMA:85391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "organ submucosa" . [] oboInOwl:hasDbXref "FMA:85392" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "region of submucosa" . [] oboInOwl:hasDbXref "FMA:85391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "submucosa of organ" . [] oboInOwl:hasDbXref "FMA:85392" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "submucosa of region of organ" . [] oboInOwl:hasDbXref "BTO:0002107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "submucous layer" . [] oboInOwl:hasDbXref "BTO:0002107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000009 ; owl:annotatedTarget "tela submucosa" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "hexadecanoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77182 ; owl:annotatedTarget "food colorings" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:hasDbXref "GO:0007422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000142" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000429" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]" . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000399" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1007/978-0-387-46954-6_6 Dupin E, Creuzet S, Le Douarin NM, The contribution of the neural crest to the vertebrate body. Advances in experimental medicine and biology (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "(...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG]" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "PNS" . [] oboInOwl:source "BIRNLEX:1111", "ncithesaurus:Peripheral_Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "UMLS:C0206417" . [] oboInOwl:source "BIRNLEX:1111" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "UMLS:C1305921" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77182 ; owl:annotatedTarget "food colourings" . [] oboInOwl:hasDbXref "FMA:9903", "FMA:TA", "Wikipedia:Peripheral_nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "pars peripherica" . [] oboInOwl:hasDbXref "FMA:9903", "FMA:TA", "Wikipedia:Peripheral_nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000010 ; owl:annotatedTarget "systema nervosum periphericum" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "FMA", "MA", "WP", "ZFA-modified-from-isa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget _:genid110921 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget _:genid110923 . [] oboInOwl:hasDbXref "GO:0048486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010488" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "Part of the autonomic nervous system which has opposing physiological effects of the sympathetic nervous system. Examples include decreasing the heart rate or dilating the blood vessels.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000755" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.634, DOI:10.1016/S0306-4530(98)00057-2 Porges SW, Love: an emergent property of the mammalian autonomic nervous system. Psychoneuroendocrinology (1998)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "In mammals, the autonomic nervous system is divided into two contrasting, antagonistic systems of control over visceral activity: the sympathetic system and the parasympathetic system (reference 1); In general, the teleosts may be considered phylogenetically the first class of vertebrates in which the heart is regulated by both sympathetic and parasympathetic neural pathways (reference 2).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:2517", "ncithesaurus:Parasympathetic_Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "UMLS:C0030510" . [] oboInOwl:source "BIRNLEX:2517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "UMLS:C1305770" . _:genid110921 oboInOwl:hasDbXref "FMA:9907", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "pars parasympathica divisionis autonomici systematis nervosi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002410 . [] oboInOwl:hasDbXref "Wikipedia:Parasympathetic_nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000011 ; owl:annotatedTarget "pars parasympathica divisionis autonomici systematis nervosi" . _:genid110923 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000010, obo:UBERON_0002342 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000012 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:hasDbXref "NLXANAT:100301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000012 ; owl:annotatedTarget "Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors." . [] oboInOwl:hasDbXref "NLXANAT:100301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000012 ; owl:annotatedTarget "somatic nervous system, somatic division" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000012 ; owl:annotatedTarget "somatic part of peripheral nervous system" . [] oboInOwl:hasDbXref "NLXANAT:100301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000012 ; owl:annotatedTarget "somatic peripheral nervous system" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77450 ; owl:annotatedTarget "a monoamide of a dicarboxylate" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "FMA", "MA", "ZFA-modified-from-isa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget _:genid110941 . [] oboInOwl:hasDbXref "GO:0048485" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010487" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000384" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000384" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.461-463", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:2516", "ncithesaurus:Sympathetic_Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "UMLS:C0039044" . [] oboInOwl:source "BIRNLEX:2516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "UMLS:C1269646" . [] oboInOwl:hasDbXref "FMA:9906", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "pars sympathica divisionis autonomici systematis nervosi" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77746 ; owl:annotatedTarget "H. sapiens metabolite" . [] oboInOwl:hasDbXref "Wikipedia:Sympathetic_nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000013 ; owl:annotatedTarget "pars sympathica divisionis autonomici systematis nervosi" . _:genid110941 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097, obo:UBERON_0002410 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000014 ; owl:annotatedTarget obo:UBERON_0034944 . [] oboInOwl:hasDbXref "Wikipedia:Skin", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000014 ; owl:annotatedTarget "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000860" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000014 ; owl:annotatedTarget "(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "MA:0000151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000014 ; owl:annotatedTarget "skin" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000015 ; owl:annotatedTarget obo:UBERON_0000466 . [] oboInOwl:hasDbXref "CARO:0000010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000015 ; owl:annotatedTarget "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77746 ; owl:annotatedTarget "H. sapiens metabolites" . [] oboInOwl:hasDbXref "CARO:0000010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000015 ; owl:annotatedTarget "anatomical boundary" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget obo:UBERON_0000471 . [] oboInOwl:source "AAO", "FMA", "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget _:genid110963 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget _:genid110967 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget _:genid110969 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget _:genid110971 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77746 ; owl:annotatedTarget "Homo sapiens metabolite" . [] oboInOwl:hasDbXref "GO:GO", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000049" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Pancreas" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001260" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]" . _:genid110963 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000049" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 . [] oboInOwl:source "PMID:20959416" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys" . [] oboInOwl:hasDbXref "BTO:0000650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000016 ; owl:annotatedTarget "endocrine part of pancreas" . _:genid110967 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030073, obo:UBERON_0002330 . _:genid110969 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0070091, obo:UBERON_0007329 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77746 ; owl:annotatedTarget "Homo sapiens metabolites" . _:genid110971 a owl:Restriction ; owl:onProperty obo:RO_0002215, obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007586, obo:GO_0070253 . [] oboInOwl:hasDbXref "GOC:GO", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001249" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000048" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Pancreas" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000048" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Exocrine_Pancreas" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "UMLS:C0553695" . [] oboInOwl:hasDbXref "BTO:0000434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000017 ; owl:annotatedTarget "exocrine part of pancreas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "EC 3.5.1.4 (amidase) inhibitors" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget _:genid110998 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget _:genid111000 . [] oboInOwl:hasDbXref "GO:0043010", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000107" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "A cavitated compound organ that transduces light waves into neural signals.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000275" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "EC 3.5.1.4 inhibitor" . [] oboInOwl:hasDbXref "FMA:54448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "eye" . [] oboInOwl:source "BIRNLEX:1169", "ncithesaurus:Eye" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "UMLS:C0015392" . [] oboInOwl:source "BIRNLEX:1169" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "UMLS:C1280202" . [] oboInOwl:hasDbXref "FMA:54448", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "regio orbitalis" . [] oboInOwl:hasDbXref "TAO:0000107" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "eyes" . [] oboInOwl:hasDbXref "FMA:54448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "orbital part of face" . [] oboInOwl:hasDbXref "FMA:54448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000019 ; owl:annotatedTarget "orbital region" . (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 ] ) . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "1-Pentadecanecarboxylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "EC 3.5.1.4 inhibitors" . ( ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/549", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "An organ that is capable of transducing sensory stimulus to the nervous system." . [] oboInOwl:source "ncithesaurus:Organ_of_the_Special_Sense" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "UMLS:C0935626" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "organ of sense organ system" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "organ of sensory organ system" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "organ of sensory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "sense organ system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "sensory organ system organ" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "sensory system organ" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "N-acetylaminohydrolase inhibitor" . [] oboInOwl:hasDbXref "WBbt:0006929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "sensillum" . [] oboInOwl:hasDbXref "BTO:0000202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000020 ; owl:annotatedTarget "Sinnesorgan" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000021 ; owl:annotatedTarget "Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales." . [] oboInOwl:hasDbXref "FMA:71012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000021 ; owl:annotatedTarget "skin appendage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "N-acetylaminohydrolase inhibitors" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000025 ; owl:annotatedTarget "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." . [] oboInOwl:hasDbXref "CARO:DOS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "Major subdivision of an organism that protrudes from the body[DOS, CARO]." . [] oboInOwl:source "BILA:0000018" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]." . [] oboInOwl:source "GO:0048736" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "EMAPA:37283" . [] oboInOwl:source "ncithesaurus:Appendage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "UMLS:C0598782" . [] oboInOwl:hasDbXref "XAO:0000218" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "appendages" . [] oboInOwl:hasDbXref "BTO:0001492" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "extremitaet" . [] oboInOwl:hasDbXref "MP:0000001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000026 ; owl:annotatedTarget "limbs/digits/tail" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "acylamidase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "acylamidase inhibitors" . [] oboInOwl:hasDbXref "BTO:0000784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000029 ; owl:annotatedTarget "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001273" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.630", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000029 ; owl:annotatedTarget "Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000029 ; owl:annotatedTarget "UMLS:C0024204" . [] oboInOwl:hasDbXref "VHOG:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000029 ; owl:annotatedTarget "lymph gland" . [] oboInOwl:hasDbXref "Wikipedia:Lymph_node" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000029 ; owl:annotatedTarget "nodus lymphaticus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "acylamide amidohydrolase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Lamina_propria" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000030 ; owl:annotatedTarget "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." . [] oboInOwl:source "ncithesaurus:Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000030 ; owl:annotatedTarget "UMLS:C1179187" . [] oboInOwl:hasDbXref "BTO:0002330" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000030 ; owl:annotatedTarget "tunica propria" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget _:genid111074 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "A lamina propria that is part of a respiratory airway." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "acylamide amidohydrolase inhibitors" . [] oboInOwl:source "ncithesaurus:Trachea_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "UMLS:C1710457" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "lamina propria mucosa of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "lamina propria mucosa of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "lamina propria mucosae of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "lamina propria mucosae of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "lamina propria of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "trachea lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "trachea lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "windpipe lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "windpipe lamina propria mucosa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidase (EC 3.5.1.4) inhibitor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000031 ; owl:annotatedTarget "windpipe lamina propria mucosae" . [] oboInOwl:hasDbXref "GO:0060322", "Wikipedia:Head" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "The head is the anterior-most division of the body [GO]." . _:genid111074 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010335" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000379 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001114" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001644" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.82", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1230", "ncithesaurus:Head" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "UMLS:C0018670" . [] oboInOwl:hasDbXref "FMA:7154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "head (volume)" . [] oboInOwl:hasDbXref "SPD:0000016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000033 ; owl:annotatedTarget "cephalic area" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidase (EC 3.5.1.4) inhibitors" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget _:genid111101 . [] oboInOwl:hasDbXref "Wikipedia:Serous_membrane", "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005425" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Wikipedia:Serous_membrane" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" . [] oboInOwl:source "Wikipedia:Serous_membrane" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." . [] oboInOwl:source "ncithesaurus:Serosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "UMLS:C0036760" . [] oboInOwl:hasDbXref "FMA:9581" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "tunica serosa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidase inhibitor" . [] oboInOwl:hasDbXref "FMA:9581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "wall of serous sac" . [] oboInOwl:hasDbXref "Wikipedia:Serous_membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000042 ; owl:annotatedTarget "serosa" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget obo:UBERON_0007846 . [] oboInOwl:source "OG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget _:genid111112 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget _:genid111114 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget _:genid111116 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000073", "Wikipedia:Tendon", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "Dense regular connective tissue that connects muscle to bone[VSAO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000073" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "Dense regular connective tissue that connects muscle to bone.[VSAO]" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "1-hexyldecanoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidase inhibitors" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001286" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" . _:genid111101 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:source "ncithesaurus:Tendon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "UMLS:C0039508" . [] oboInOwl:hasDbXref "Wikipedia:Tendon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "sinew" . [] oboInOwl:hasDbXref "Wikipedia:Tendon" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000043 ; owl:annotatedTarget "tendo" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget _:genid111129 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget _:genid111131 . [] oboInOwl:inconsistent_with "BTO" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget obo:UBERON_0002420 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidohydrolase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Ganglion", "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "A biological tissue mass, most commonly a mass of nerve cell bodies." . [] oboInOwl:source "PMID:21062451" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures" . _:genid111112 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010426" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002204 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000190" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]" . _:genid111114 oboInOwl:source "NLXANAT:100302" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302]." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000156" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.02.021 Mazet F, Hutt JA, Milloz J, Millard J, Graham A, Shimeld SM, Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]" . _:genid111116 oboInOwl:source "ncithesaurus:Ganglion" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "UMLS:C0017067" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000327 . [] oboInOwl:hasDbXref "BTO:0000497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000045 ; owl:annotatedTarget "neural ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Eye#Simple_eyes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000047 ; owl:annotatedTarget "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "amidohydrolase inhibitors" . [] oboInOwl:hasDbXref "MESH:A09.371.729.522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000053 ; owl:annotatedTarget "An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)." . [] oboInOwl:source "BIRNLEX:2540", "ncithesaurus:Macula_Lutea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000053 ; owl:annotatedTarget "UMLS:C0450295" . [] oboInOwl:source "BIRNLEX:2540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000053 ; owl:annotatedTarget "UMLS:C1284755" . [] oboInOwl:hasDbXref "BTO:0003015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000053 ; owl:annotatedTarget "macula flava retinae" . [] oboInOwl:hasDbXref "BTO:0003015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000053 ; owl:annotatedTarget "macula retinae" . [] oboInOwl:hasDbXref "MESH:A09.246.631.909.625.125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000386" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "Patches of thickened, pseudostratified epithelium of the inner ear, consisting of regular arrays of sensory hair cells interspersed with supporting cells. Each patch has its own charcteristic shape and polarity pattern. (See Anatomical Atlas entry for sensory patches of the ear by T. Whitfield.)[TAO]" . _:genid111129 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "maculae" ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0003714 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "deaminase inhibitor" . [] oboInOwl:hasDbXref "ZFA:0000386" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "sensory macula" . _:genid111131 oboInOwl:hasDbXref "ZFA:0000386" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "sensory patch" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0003869 . [] oboInOwl:hasDbXref "MESH:A09.246.631.909.625.125" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "acoustic macula" . [] oboInOwl:hasDbXref "MESH:A09.246.631.909.625.125" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000054 ; owl:annotatedTarget "acoustic maculae" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000055 ; owl:annotatedTarget "A tubular structure that contains, conveys body fluid, such as blood or lymph." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "deaminase inhibitors" . [] oboInOwl:hasDbXref "MA:0000378" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget _:genid111160 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget _:genid111162 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget _:genid111166 . [] oboInOwl:hasDbXref "GO:0090189", "Wikipedia:Ureter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010254" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000605" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000605" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Ureter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "UMLS:C0041951" . [] oboInOwl:hasDbXref "ISBN:0073040584", "VHOG:0000605" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000056 ; owl:annotatedTarget "metanephric duct" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "fatty acylamidase inhibitor" . [] oboInOwl:notes "pelvic part of UG sinus gives rise to prostatic and membranous parts of urethra" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000057 ; owl:annotatedTarget _:genid111179 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000057 ; owl:annotatedTarget _:genid111181 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0000537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000057 ; owl:annotatedTarget "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." . [] oboInOwl:source "ncithesaurus:Urethra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000057 ; owl:annotatedTarget "UMLS:C0041967" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77941 ; owl:annotatedTarget "fatty acylamidase inhibitors" . _:genid111160 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002355, obo:UBERON_0034969 . _:genid111162 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002570 ; owl:someValuesFrom obo:UBERON_0000463, obo:UBERON_0011143 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm#ducts" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000058 ; owl:annotatedTarget "A tubular structure that transports secreted or excreted substances." . [] oboInOwl:source "ZFA:0005171" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000058 ; owl:annotatedTarget "A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]." . [] oboInOwl:source "ncithesaurus:Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000058 ; owl:annotatedTarget "UMLS:C0687028" . _:genid111166 oboInOwl:hasDbXref "XAO:0004000" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000058 ; owl:annotatedTarget "ducts" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005081 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77968 ; owl:annotatedTarget "humectants" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000059 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Large_intestine_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000059 ; owl:annotatedTarget "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000054" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000059 ; owl:annotatedTarget "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Large_Intestine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000059 ; owl:annotatedTarget "UMLS:C0021851" . [] oboInOwl:hasDbXref "BTO:0000706" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000059 ; owl:annotatedTarget "intestinum crassum" . [] oboInOwl:hasDbXref "FMA:82482" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000060 ; owl:annotatedTarget "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000060 ; owl:annotatedTarget "in FMA, serosa is a wall" . _:genid111179 oboInOwl:hasDbXref "FMA:82482" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000060 ; owl:annotatedTarget "wall of organ" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000164 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77969 ; owl:annotatedTarget "food humectants" . [] oboInOwl:hasDbXref "FMA:82482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000060 ; owl:annotatedTarget "organ wall" . _:genid111181 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002497 ; owl:someValuesFrom obo:UBERON_0000071, obo:UBERON_0013241 . [] oboInOwl:hasDbXref "CARO:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000061 ; owl:annotatedTarget "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." . [] oboInOwl:hasDbXref "CARO:0000003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000061 ; owl:annotatedTarget "connected biological structure" . [] oboInOwl:source "PMID:28192867" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget obo:UBERON_0002095 . [] oboInOwl:hasDbXref "Wikipedia:Organ_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget "Anatomical structure that performs a specific function or group of functions [WP]." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget obo:NCBITaxon_110815 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_77974 ; owl:annotatedTarget "food packaging gases" . [] oboInOwl:source "GO:0048513" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." . [] oboInOwl:source "ncithesaurus:Organ" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget "UMLS:C0178784" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000062 ; owl:annotatedTarget "element" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." . [] oboInOwl:source "FMA:86140" ; oboInOwl:version "3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball." . [] oboInOwl:source "FMA:86140" ; oboInOwl:version "1" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal." . [] oboInOwl:hasDbXref "FMA:86140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "organ region with fixed fiat boundary" . [] oboInOwl:hasDbXref "FMA:86140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "organ segment" . [] oboInOwl:hasDbXref "FMA:86140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000063 ; owl:annotatedTarget "segment of organ" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "16:00" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78017 ; owl:annotatedTarget "food propellants" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000064 ; owl:annotatedTarget "A multicellular structure that is a part of an organ." . [] oboInOwl:hasDbXref "FMA:82472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000064 ; owl:annotatedTarget "cardinal organ part" . [] oboInOwl:hasDbXref "BIRNLEX:16" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000064 ; owl:annotatedTarget "regional part of organ" . [] oboInOwl:source "NCBIBook:NBK10107" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000065 ; owl:annotatedTarget _:genid111233 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000065 ; owl:annotatedTarget "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78113 ; owl:annotatedTarget "fatty acid 3:0" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000066 ; owl:annotatedTarget "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000068 ; owl:annotatedTarget "A life cycle stage that starts with fertilization and ends with the fully formed embryo." . [] oboInOwl:hasDbXref "XAO:0000437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000071 ; owl:annotatedTarget "End of the life of an organism." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000071 ; owl:annotatedTarget "ncit:Death is an outcome" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000072 ; owl:annotatedTarget "An section of a respiratory tract." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000072 ; owl:annotatedTarget "MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole" . [] oboInOwl:hasDbXref "MA:0000434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000072 ; owl:annotatedTarget "respiratory tract" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78115 ; owl:annotatedTarget "fatty acid 4:0" . [] oboInOwl:hasDbXref "BIRNLEX:1157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000073 ; owl:annotatedTarget "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." . [] oboInOwl:source "ncithesaurus:Nervous_System_Part" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000073 ; owl:annotatedTarget "UMLS:C1518256" . _:genid111233 oboInOwl:hasDbXref "BIRNLEX:1157" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000073 ; owl:annotatedTarget "part of nervous system" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007026 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget _:genid111264 . [] oboInOwl:hasDbXref "MP:0005325", "Wikipedia:Glomerulus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule?" . [] oboInOwl:source "ncithesaurus:Glomerulus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "UMLS:C0022663" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78116 ; owl:annotatedTarget "fatty acid 6:0" . [] oboInOwl:hasDbXref "TAO:0001288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "renal glomeruli" . [] oboInOwl:hasDbXref "BTO:0000530" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "Malphigian glomerulus" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/malpighian+glomerulus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "Malpighian glomerulus" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/malpighian+glomerulus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "Malpighian tuft" . [] oboInOwl:hasDbXref "ZFA:0001288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "glomerular capillary tuft" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "glomerular tuft" . [] oboInOwl:hasDbXref "Wikipedia:Glomerulus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "glomerulus renis" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000074 ; owl:annotatedTarget "renal corpuscle" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78121 ; owl:annotatedTarget "fatty acid 14:0" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000075 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000075 ; owl:annotatedTarget "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." . [] oboInOwl:source "ncithesaurus:Skeletal_System_Part" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000075 ; owl:annotatedTarget "UMLS:C1519343" . [] oboInOwl:hasDbXref "FMA:85544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000075 ; owl:annotatedTarget "skeletal system subdivision" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000076 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000076 ; owl:annotatedTarget _:genid111287 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0012532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000076 ; owl:annotatedTarget "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." . [] oboInOwl:source "ncithesaurus:Surface_Ectoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000076 ; owl:annotatedTarget "UMLS:C1515087" . [] oboInOwl:hasDbXref "MP:0012532" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000076 ; owl:annotatedTarget "surface ectoderm" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78123 ; owl:annotatedTarget "fatty acid 16:0" . _:genid111264 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926, obo:UBERON_0001229 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000077 ; owl:annotatedTarget "An anatomical structure that develops from the endoderm and the mesoderm." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78125 ; owl:annotatedTarget "fatty acid 18:0" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000078 ; owl:annotatedTarget "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78295 ; owl:annotatedTarget "dietary component" . [] oboInOwl:hasDbXref "MP:0001145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "The organs associated with producing offspring in the gender that produces spermatozoa." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000725" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Male_Genitalia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "UMLS:C0017422" . [] oboInOwl:source "ncithesaurus:Male_Reproductive_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "UMLS:C1963704" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "genitalia of male organism" . [] oboInOwl:hasDbXref "FMA:45664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "male genital system" . _:genid111287 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "male organism genitalia" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "male organism reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "reproductive system of male organism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78295 ; owl:annotatedTarget "dietary components" . [] oboInOwl:hasDbXref "BTO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "male genital organ" . [] oboInOwl:hasDbXref "MA:0000396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "male reproductive tract" . [] oboInOwl:hasDbXref "BTO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000079 ; owl:annotatedTarget "systema genitale masculinum" . [] oboInOwl:hasDbXref "GO:0001823", "Wikipedia:Mesonephros" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000038" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "A kidney formed of nephric tubules arising in the middle region of the nephric ridge; a transient embryonic stage that replaces the pronephros, but is itself replaced by the adult metanephros [in mammals; in fishes and amphibians it is the adult kidney]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010384" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "Organ that is the definitive adult kidney. It replaces the earlier pronephros, which degenerates as the mesonephros becomes functional in feeding stage tadpoles.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000038" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates. (...) In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Mesonephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "UMLS:C0025492" . [] oboInOwl:hasDbXref "BTO:0001542", "GOC:yaf", "MESH:A16.254.500", "Wikipedia:Mesonephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "Wolffian body" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "C16" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78295 ; owl:annotatedTarget "food components" . [] oboInOwl:hasDbXref "XAO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "mesonephric kidney" . [] oboInOwl:hasDbXref "http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "mesonephroi" . [] oboInOwl:hasDbXref "XAO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "amphibian adult kidney" . [] oboInOwl:hasDbXref "BTO:0001542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "corpus Wolffi" . [] oboInOwl:hasDbXref "BTO:0001542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "middle kidney" . [] oboInOwl:hasDbXref "VHOG:0000038", "XAO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "opisthonephros" . [] oboInOwl:hasDbXref "http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000080 ; owl:annotatedTarget "opistonephros" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget _:genid111339 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78298 ; owl:annotatedTarget "environmental contaminants" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget _:genid111341 . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget _:genid111344 . [] oboInOwl:hasDbXref "GO:0001656", "Wikipedia:Metanephros#Metanephros" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000039" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "A kidney formed of nephric tubules arising in the posterior region of the nephric ridge and drained by a ureter; replaces the embryonic pronephros and mesonephros [in mammals]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000039" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Metanephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "UMLS:C0231049" . [] oboInOwl:hasDbXref "BTO:0001543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "metanephron" . [] oboInOwl:hasDbXref "BTO:0001543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "definite kidney" . [] oboInOwl:hasDbXref "BTO:0001543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "definitive kidney" . [] oboInOwl:hasDbXref "BTO:0001543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "hind kidney" . [] oboInOwl:hasDbXref "VHOG:0000039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000081 ; owl:annotatedTarget "metanephric kidney" . [] oboInOwl:hasDbXref "Wikipedia:Mesonephric_tubules" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000083 ; owl:annotatedTarget "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000500" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mesonephric+tubule" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000083 ; owl:annotatedTarget "Any of the renal tubules composing the mesonephros. In mammals they function as excretory structures during the early embryonic development but are later incorporated into the reproductive system. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000500" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000083 ; owl:annotatedTarget "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000500" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000083 ; owl:annotatedTarget "renal tubules" . [] oboInOwl:hasDbXref "Wikipedia:Mesonephric_tubules" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000083 ; owl:annotatedTarget "tubuli mesonephrici" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget _:genid111367 . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget _:genid111369 . [] oboInOwl:hasDbXref "MP:0010979", "PMID:19828308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000541" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts. [Embryology, See_Dudek_RW_and_Fix_JD, Third_Edition_(2004)_Philadelphia:_Lippincott_William_and_Wilkins, p.137][VHOG]" . [] oboInOwl:source "VHOG:0000541" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts[VHOG:0000541]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000541" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Metanephric_Diverticulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "UMLS:C1284058" . _:genid111339 oboInOwl:hasDbXref "BTO:0001646" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "diverticulum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003220 . [] oboInOwl:hasDbXref "Wikipedia:Ureteric_bud" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "diverticulum metanephricum" . _:genid111341 oboInOwl:hasDbXref "Wikipedia:Ureteric_bud" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "gemma ureterica" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005080 . [] oboInOwl:hasDbXref "BTO:0001646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "metanephric bud" . [] oboInOwl:hasDbXref "Wikipedia:Metanephros#Metanephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "metanephric diverticulum" . _:genid111344 oboInOwl:hasDbXref "VHOG:0000541" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000084 ; owl:annotatedTarget "ureteric diverticulum" ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0000080 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000085 ; owl:annotatedTarget _:genid111382 . [] oboInOwl:hasDbXref "MP:0012130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000085 ; owl:annotatedTarget "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000085 ; owl:annotatedTarget "EHDAA2 has embryo starting later" . [] oboInOwl:source "ncithesaurus:Morula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000085 ; owl:annotatedTarget "UMLS:C0026573" . [] oboInOwl:hasDbXref "EHDAA2:0000005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000085 ; owl:annotatedTarget "morula (2-16 cells)" . [] oboInOwl:hasDbXref "Wikipedia:Zona_pellucida" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000720" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "zona pellucida - vitelline membrane" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_78320 ; owl:annotatedTarget "CAS:50-21-5" . [] oboInOwl:source "ncithesaurus:Zona_Pellucida" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "UMLS:C0043519" . [] oboInOwl:hasDbXref "BTO:0003135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "oolemma" . [] oboInOwl:hasDbXref "BTO:0003135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "pellucid zone" . [] oboInOwl:hasDbXref "BTO:0003135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "striated membrane" . [] oboInOwl:hasDbXref "BTO:0003135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "zona radiata" . [] oboInOwl:hasDbXref "BTO:0003135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000086 ; owl:annotatedTarget "zona striata" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget _:genid111404 . _:genid111367 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget _:genid111406 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003074 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget _:genid111408 . _:genid111369 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget _:genid111410 ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0003220 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_78320 ; owl:annotatedTarget "2-Hydroxypropanoic acid" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:pvb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000742" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000742" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Inner_Cell_Mass" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "UMLS:C1283994" . [] oboInOwl:hasDbXref "VHOG:0000742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "ICM" . [] oboInOwl:hasDbXref "FMA:86557" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "early embryoblast" . [] oboInOwl:hasDbXref "Wikipedia:Inner_cell_mass" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000087 ; owl:annotatedTarget "embryoblastus; massa cellularis interna; pluriblastus senior" . [] oboInOwl:source "MP-def", "PMID:19829370" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget _:genid111420 . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_78320 ; owl:annotatedTarget "2-hydroxypropanoic acid" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." . [] oboInOwl:date_retrieved "2012-08-23" ; oboInOwl:external_class "MP:0005031" ; oboInOwl:external_class_label "trophoblast layer" ; oboInOwl:ontology "MP" ; oboInOwl:source "ISBN:0-683-40008-8" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" . _:genid111382 oboInOwl:source "PMID:19829370" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004716 . [] oboInOwl:source "ncithesaurus:Trophoblast" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "UMLS:C0041178" . [] oboInOwl:hasDbXref "MP:0005031" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "trophoblast layer" . [] oboInOwl:hasDbXref "Wikipedia:Trophoblast" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "massa cellularis externa" . [] oboInOwl:hasDbXref "Wikipedia:Trophoblast" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "trophoblastus" . [] oboInOwl:hasDbXref "BTO:0001079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000088 ; owl:annotatedTarget "trophoderm" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget _:genid111431 . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78320 ; owl:annotatedTarget "2-Hydroxypropionic acid" . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "embryonic disc" . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "embryonic shield" . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "germinal disc" . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "germinal disk" . [] oboInOwl:source "ncithesaurus:Bilaminar_Embryonic_Disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "UMLS:C1283997" . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "bilaminary germ disc" . [] oboInOwl:hasDbXref "Wikipedia:Bilaminar_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000091 ; owl:annotatedTarget "bilaminar disk" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "C16 fatty acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78320 ; owl:annotatedTarget "Lactic acid" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000092 ; owl:annotatedTarget "Stage succeeding embryo, including mature structure." . [] oboInOwl:hasDbXref "Wikipedia:Sulcus_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000093 ; owl:annotatedTarget "A depression or fissure in the surface of an organ." . [] oboInOwl:source "FMA-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000094 ; owl:annotatedTarget _:genid111446 . [] oboInOwl:hasDbXref "FMA:7145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000094 ; owl:annotatedTarget "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." . _:genid111404 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922, obo:UBERON_0002342 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget _:genid111450 . _:genid111406 oboInOwl:hasDbXref "Wikipedia:Cardiac_neural_crest" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000085 . [] oboInOwl:source "DOI:10.1242/dev.091751" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget "A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]." . _:genid111408 oboInOwl:external_ontology "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget "ZFA treats this as a subtype of NC." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000358 . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_neural_crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget "cardiac neural crest complex" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78433 ; owl:annotatedTarget "refrigerants" . _:genid111410 oboInOwl:hasDbXref "Wikipedia:Cardiac_neural_crest" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000095 ; owl:annotatedTarget "complexus cristae neuralis cardiacus" ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000088 . [] oboInOwl:hasDbXref "GOC:GO" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000102 ; owl:annotatedTarget "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000102 ; owl:annotatedTarget "lung vascular network" . [] oboInOwl:hasDbXref "FMA:73750" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000102 ; owl:annotatedTarget "pulmonary vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000102 ; owl:annotatedTarget "vascular network of lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000102 ; owl:annotatedTarget "vasculature of lung" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "Alpha-carboxylesterase inhibitor" . _:genid111420 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000105, obo:UBERON_0004345 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000104 ; owl:annotatedTarget "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000105 ; owl:annotatedTarget "A spatiotemporal region encompassing some part of the life cycle of an organism." . [] oboInOwl:hasDbXref "Wikipedia:Zygote" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "A stage at which the organism is a single cell produced by means of sexual reproduction." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000745" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" . [] oboInOwl:hasDbXref "BTO:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "fertilized egg stage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "Alpha-carboxylesterase inhibitors" . [] oboInOwl:hasDbXref "VHOG:0000745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "one-cell stage" . _:genid111431 oboInOwl:hasDbXref "VHOG:0000745" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "zygote" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000087 . [] oboInOwl:hasDbXref "Wikipedia:Zygote" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000106 ; owl:annotatedTarget "zygotum" . [] oboInOwl:hasDbXref "GO:0040016", "Wikipedia:Cleavage_(embryo)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000107 ; owl:annotatedTarget "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "Beta-esterase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Blastula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000108 ; owl:annotatedTarget "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." . [] oboInOwl:source "BILS" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget _:genid111490 . _:genid111446 oboInOwl:hasDbXref "GO:0007369" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0011823 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "blastocystis trilaminaris stage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "trilaminar blastocyst stage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "trilaminar blastoderm stage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "Beta-esterase inhibitors" . _:genid111450 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "trilaminar disk stage" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0005428 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "trilaminar germ stage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000109 ; owl:annotatedTarget "trilaminar stage" . [] oboInOwl:hasDbXref "GO:0001841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000110 ; owl:annotatedTarget "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." . [] oboInOwl:hasDbXref "Wikipedia:Organogenesis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000111 ; owl:annotatedTarget "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "EC 3.1.1.1 (carboxylesterase) inhibitors" . [] oboInOwl:source "XAO:1000010" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000112 ; owl:annotatedTarget "The stage of being a sexually immature adult animal[XAO:1000010]." . [] oboInOwl:hasDbXref "VHOG:FB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000112 ; owl:annotatedTarget "immature stage" . [] oboInOwl:hasDbXref "XAO:1000010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000112 ; owl:annotatedTarget "juvenile stage" . [] oboInOwl:hasDbXref "http://eol.org/schema/terms/subadult" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000112 ; owl:annotatedTarget "subadult stage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000113 ; owl:annotatedTarget "The stage of being a sexually mature adult animal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "ali-esterase inhibitor" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:anna", "MP:0002276", "PMID:14635660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000114 ; owl:annotatedTarget "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000114 ; owl:annotatedTarget "connective tissue of lung" . [] oboInOwl:hasDbXref "FMA:27533" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000114 ; owl:annotatedTarget "pulmonary interstitium" . [] oboInOwl:hasDbXref "MA:0001782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000114 ; owl:annotatedTarget "lung interstitial tissue" . [] oboInOwl:hasDbXref "EMAPA:35521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000114 ; owl:annotatedTarget "pulmonary connective tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "ali-esterase inhibitors" . [] oboInOwl:hasDbXref "MP:0006382" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000115 ; owl:annotatedTarget "The epithelial layer of the lung." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000115 ; owl:annotatedTarget "epithelial tissue of lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000115 ; owl:annotatedTarget "epithelium of lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000115 ; owl:annotatedTarget "lung epithelial tissue" . [] oboInOwl:hasDbXref "BTO:0001653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000115 ; owl:annotatedTarget "pulmonary epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "butyrate esterase inhibitor" . _:genid111490 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000025 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000065 ] ) ; owl:onProperty obo:BFO_0000062 ; owl:someValuesFrom obo:UBERON_0000108 . [] oboInOwl:hasDbXref "GO:0030323", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class)" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "EMAPA:37946" . [] oboInOwl:hasDbXref "FMA:12224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "segment of tracheobronchial tree" . [] oboInOwl:hasDbXref "MP:0004391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "respiratory conducting tube" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "C16:0" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "butyrate esterase inhibitors" . [] oboInOwl:hasDbXref "FMA:12224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "segment of tracheobronchial tree" . [] oboInOwl:hasDbXref "FMA:12224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000117 ; owl:annotatedTarget "tracheobronchial tree segment" . [] oboInOwl:source "GO:0060441" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget obo:UBERON_0005153 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget _:genid111551 . [] oboInOwl:hasDbXref "GO:0060431", "Wikipedia:Respiratory_bud" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "Structure derived from foregut that becomes a lung[GO]." . [] oboInOwl:source "ncithesaurus:Primary_Bronchial_Bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "UMLS:C1514420" . [] oboInOwl:source "ncithesaurus:Respiratory_Diverticulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "UMLS:C1514897" . [] oboInOwl:hasDbXref "Wikipedia:Lung_buds" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "gemma pulmonalis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "butyryl esterase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Lung_buds" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "gemma respiratoria" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "lung bud" . [] oboInOwl:hasDbXref "GO:0060572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "primary lung bud" . [] oboInOwl:hasDbXref "Wikipedia:Lung_buds" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000118 ; owl:annotatedTarget "respiratory diverticulum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000119 ; owl:annotatedTarget "Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium." . [] oboInOwl:hasDbXref "NCIT:C66831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000119 ; owl:annotatedTarget "layer" . [] oboInOwl:hasDbXref "CARO:0001001", "FBC:DOS", "FBbt:00005099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000122 ; owl:annotatedTarget "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "butyryl esterase inhibitors" . [] oboInOwl:hasDbXref "FBbt:00005099" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000122 ; owl:annotatedTarget "nerve fiber bundle" . [] oboInOwl:source "CUMBO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget _:genid111569 . [] oboInOwl:hasDbXref "NLX:28443" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." . [] oboInOwl:source "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget "Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]." . [] oboInOwl:hasDbXref "FMA:83686" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget "neuraxis nucleus" . [] oboInOwl:hasDbXref "AEO:0000136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget "neuronal nucleus" . [] oboInOwl:hasDbXref "NLX:28443" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000125 ; owl:annotatedTarget "nucleus of CNS" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxyl ester hydrolase inhibitor" . [] oboInOwl:hasDbXref "NLX:28532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000126 ; owl:annotatedTarget "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000126 ; owl:annotatedTarget "EMAPA:37066" . [] oboInOwl:hasDbXref "FMA:54501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000126 ; owl:annotatedTarget "cranial neural nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Cranial_nerve_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000126 ; owl:annotatedTarget "nucleus nervi cranialis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxyl ester hydrolase inhibitors" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget _:genid111591 . [] oboInOwl:hasDbXref "ISBN:0838580343", "MP:0000909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "The group of motor neurons residing in the pons that innervate the muscles of facial expression." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "FMA has 3 subclasses - left, right and motor nucleus of facial nerve, but no defs. It's not clear how facial nucleus is distinct from facial motor nucleus." . [] oboInOwl:source "ncithesaurus:Facial_Nerve_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "UMLS:C0228740" . [] oboInOwl:hasDbXref "MA:0001014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "facial VII nucleus" . [] oboInOwl:hasDbXref "FMA:54572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "nucleus of facial nerve" . [] oboInOwl:hasDbXref "MA:0001014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000127 ; owl:annotatedTarget "facial VII motor nucleus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylate esterase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Olivary_body" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000128 ; owl:annotatedTarget "Prominent oval structure in the medulla oblongata, present in pairs, the lower portion of the brainstem. They contain the olivary nuclei." . _:genid111551 oboInOwl:hasDbXref "Wikipedia:Olivary_body" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000128 ; owl:annotatedTarget "oliva" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008947 . [] oboInOwl:hasDbXref "BTO:0002299" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000128 ; owl:annotatedTarget "olivary nucleus" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0000153 ; owl:annotatedTarget obo:UBERON_0000154 . [] oboInOwl:source "ncithesaurus:Membrane" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000158 ; owl:annotatedTarget "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures." . [] oboInOwl:hasDbXref "FMA:82500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000158 ; owl:annotatedTarget "membranous organ component" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylate esterase inhibitors" . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000159 ; owl:annotatedTarget _:genid111612 . [] oboInOwl:hasDbXref "Wikipedia:Anal_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000159 ; owl:annotatedTarget "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." . [] oboInOwl:source "ncithesaurus:Anal_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000159 ; owl:annotatedTarget "UMLS:C0227411" . [] oboInOwl:hasDbXref "BTO:0001978", "Wikipedia:Anal_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000159 ; owl:annotatedTarget "canalis analis" . [] oboInOwl:hasDbXref "BTO:0001978" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000159 ; owl:annotatedTarget "pars analis recti" . _:genid111569 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001007, obo:UBERON_0001017 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylesterase inhibitor" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000160 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "GOC:GO", "Wikipedia:Intestine" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000160 ; owl:annotatedTarget "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000246" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000160 ; owl:annotatedTarget "Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000056" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000160 ; owl:annotatedTarget "The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:source "ncithesaurus:Intestine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000160 ; owl:annotatedTarget "UMLS:C0021853" . [] oboInOwl:hasDbXref "FMA:3724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000161 ; owl:annotatedTarget "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000161 ; owl:annotatedTarget "in FMA, this is an anatomical conduit *space*, rather than anatomical conduit" . [] oboInOwl:hasDbXref "FMA:3724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000161 ; owl:annotatedTarget "anatomical ostium" . [] oboInOwl:hasDbXref "FMA:3724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000161 ; owl:annotatedTarget "anatomical orifice" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget _:genid111630 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylesterase inhibitors" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget _:genid111632 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Cloaca" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." . [] oboInOwl:notes "most adult placentals have no trace of a cloaca. However, the tenrecs and golden moles, small placental mammals native to Africa, retain a cloaca as adults." ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget obo:NCBITaxon_9369 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001186" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/cloaca" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "A common passage for fecal, urinary, and reproductive discharge in most lower vertebrates as well as the terminal end of the hindgut before division into rectum, bladder, and genital primordia in mammalian embryos. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000095" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "Anatomical structure which is the common receptacle for the alimentary canal, Wolffian ducts, oviducts, and the bladder.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001186" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.572", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "A cloaca is apparently a primitive vertebrate feature because it occurs in most primitive gnathostomes and persists in the embryos of almost all vertebrates.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "hindgut endoderm and proctodeal ectoderm." . [] oboInOwl:source "ncithesaurus:Cloaca" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "UMLS:C0008987" . [] oboInOwl:hasDbXref "AAO:0000095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "cloacal chamber" . [] oboInOwl:hasDbXref "XAO:0000244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000162 ; owl:annotatedTarget "vent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic acid esterase inhibitor" . _:genid111591 a owl:Restriction ; owl:onProperty obo:RO_0002254, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0003064, obo:UBERON_0010123 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000163 ; owl:annotatedTarget _:genid111644 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000163 ; owl:annotatedTarget _:genid111646 . [] oboInOwl:hasDbXref "MP:0010115", "Wikipedia:Cloaca_(embryology)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000163 ; owl:annotatedTarget "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000163 ; owl:annotatedTarget "cloaca" . [] oboInOwl:source "MP-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget _:genid111651 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget _:genid111653 . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "CH3-[CH2]14-COOH" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic acid esterase inhibitors" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000414" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/urogenital+sinus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000414" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676678 Romer AS, Vertebrate body (1970)p.388-89 and Figure 300", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "In mammals the lowly monotremes still have a cloaca. Higher types have done away with this structure and have a separate anal outlet for the rectum. The monotreme cloaca shows the initiation of this subdivision. The cloaca has such includes only the distal part, roughly comparable to the proctodeum. The more proximal part is divided into (1) a large dorsal passage into which the intestine opens, the coprodeum, and (2) a ventral portion, the urodeum with which the bladder connects. (...) the development of the placental mammals recapitulates in many respects the phylogenetic story. In the sexually indifferent stage of placental mammal there is a cloaca. While the indifferent stage still persists, a septum develops, and extends out to the closing membrane. This divides the cloaca into two chambers: a coprodeum continuous with the gut above, and a urodeum or urogenital sinus below.[well established][VHOG]" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "the term 'urogenital sinus' may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal" . [] oboInOwl:hasDbXref "MP:0010116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "urogenital sinus" . [] oboInOwl:source "ncithesaurus:Urogenital_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "UMLS:C0231057" . [] oboInOwl:hasDbXref "MP:0010116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "UGS" . [] oboInOwl:hasDbXref "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "fetal UGS" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000164 ; owl:annotatedTarget "sinus urogenitalis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic esterase inhibitor" . ( ) . [] oboInOwl:notes "the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:notes "exceptions in some taxa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget _:genid111672 . [] oboInOwl:hasDbXref "Wikipedia:Mouth", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010355" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000812" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic esterase inhibitors" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips" . [] oboInOwl:hasDbXref "BTO:0004698", "FMA:49184", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "regio oralis" . [] oboInOwl:hasDbXref "Wikipedia:Mouth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "cavital oralis" . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "cavitas oris" . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "cavum oris" . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "mouth cavity" . [] oboInOwl:hasDbXref "EHDAA2:0001326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "oral region" . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "oral vestibule" . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "rima oris" . [] oboInOwl:hasDbXref "VHOG:0000812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "stomatodaeum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic-ester hydrolase inhibitor" . _:genid111630 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "trophic apparatus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 . [] oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "vestibule of mouth" . _:genid111632 oboInOwl:hasDbXref "BTO:0001090" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000165 ; owl:annotatedTarget "vestibulum oris" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004122 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget obo:UBERON_0000161 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget "The orifice that connects the mouth to the exterior of the body." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000280" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:59806" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget "oral fissure" . [] oboInOwl:hasDbXref "FMA:59806" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget "oral orifice" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000166 ; owl:annotatedTarget "mouth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "carboxylic-ester hydrolase inhibitors" . _:genid111644 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165, obo:UBERON_0001008 . _:genid111646 oboInOwl:hasDbXref "ISBN:0073040584", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012361 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000960" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000188" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/oral+cavity" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000188" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.32", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "cocaine esterase inhibitor" . [] oboInOwl:source "ncithesaurus:Oral_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "UMLS:C0226896" . _:genid111651 oboInOwl:hasDbXref "FMA:20292", "ISBN:0073040584" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000167 ; owl:annotatedTarget "buccal cavity" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000163 . (obo:UBERON_0013522 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0001155 ] ) . [] oboInOwl:order "4" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000168 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000168 ; owl:annotatedTarget "A section dividing a colon along a proximal-distal axis." . [] oboInOwl:hasDbXref "FMA:222905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000168 ; owl:annotatedTarget "segment of colon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "cocaine esterase inhibitors" . [] oboInOwl:source "FMA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000170 ; owl:annotatedTarget _:genid111724 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase A inhibitor" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000170 ; owl:annotatedTarget "The pair of anatomical structures comprised of a left lung and right lung." . [] oboInOwl:hasDbXref "FMA:68877", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000170 ; owl:annotatedTarget "pulmones" . _:genid111672 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0007585 ] ) ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001004 . [] oboInOwl:hasDbXref "GO:0007585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000171 ; owl:annotatedTarget "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000171 ; owl:annotatedTarget "apparatus respiratorius organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000171 ; owl:annotatedTarget "organ of apparatus respiratorius" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase A inhibitors" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000171 ; owl:annotatedTarget "organ of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000171 ; owl:annotatedTarget "respiratory system organ" . [] oboInOwl:hasDbXref "ENVO:02000021", "MP:MP" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000173 ; owl:annotatedTarget "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." . [] oboInOwl:source "ncithesaurus:Amniotic_Fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000173 ; owl:annotatedTarget "UMLS:C0002638" . [] oboInOwl:hasDbXref "BTO:0000068" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000173 ; owl:annotatedTarget "acqua amnii" . [] oboInOwl:hasDbXref "BTO:0000068" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000173 ; owl:annotatedTarget "liquor amnii" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase B inhibitor" . [] oboInOwl:hasDbXref "GO:0007588", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000174 ; owl:annotatedTarget "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." . [] oboInOwl:hasDbXref "FMA:9674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000174 ; owl:annotatedTarget "portion of excreted substance" . [] oboInOwl:hasDbXref "AEO:0000184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000174 ; owl:annotatedTarget "waste substance" . [] oboInOwl:hasDbXref "BTO:0000491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000174 ; owl:annotatedTarget "excretion" . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget _:genid111757 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "FA 16:0" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase B inhibitors" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/1330" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget _:genid111760 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget _:genid111762 . [] oboInOwl:hasDbXref "FMA:9670", "Wikipedia:Blood", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "A fluid that is composed of blood plasma and erythrocytes." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000007" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000046" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000046" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000224" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual review of cell and developmental biology (2006) ", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Blood" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "UMLS:C0005767" . [] oboInOwl:hasDbXref "BTO:0000089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000178 ; owl:annotatedTarget "whole blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase D inhibitor" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000179 ; owl:annotatedTarget "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000199 ; owl:annotatedTarget _:genid111780 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=58913" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000199 ; owl:annotatedTarget "The narrow part of the shaft of the radius just below the head." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "esterase D inhibitors" . [] oboInOwl:hasDbXref "_rib" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000199 ; owl:annotatedTarget "collum radii" . [] oboInOwl:hasDbXref "FMA:23479" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000199 ; owl:annotatedTarget "radial neck" . _:genid111724 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0001558, obo:UBERON_0013118 . [] oboInOwl:hasDbXref "Wikipedia:Gyrus", "https://github.com/obophenotype/uberon/issues/573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "A ridge on the cerebral cortex. It is generally surrounded by one or more sulci ." . [] oboInOwl:source "ncithesaurus:Cerebral_Gyrus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "UMLS:C0458308" . [] oboInOwl:hasDbXref "BTO:0002495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "cerebral gyrus" . [] oboInOwl:hasDbXref "FMA:83874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "gyrus of neuraxis" . [] oboInOwl:hasDbXref "FMA:83874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "neuraxis gyrus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "methylbutyrase inhibitor" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "folia" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "folium" . [] oboInOwl:hasDbXref "BTO:0002495" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "gyri" . [] oboInOwl:hasDbXref "BTO:0002495" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "gyri of cerebrum" . [] oboInOwl:hasDbXref "FMA:83874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "gyrus of cerebral hemisphere" . [] oboInOwl:hasDbXref "BTO:0002495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000200 ; owl:annotatedTarget "gyrus of cerebrum" . [] oboInOwl:hasDbXref "GO:0021543", "ISBN:0471888893", "Wikipedia:Pallium_(neuroanatomy)", "https://github.com/obophenotype/uberon/issues/287" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "Dorsal part (roof region) of the telencephalon[GO]." . [] oboInOwl:source "Wikipedia:Avian_pallium" ; oboInOwl:taxon "NCBITaxon:8782" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "methylbutyrase inhibitors" . [] oboInOwl:hasDbXref "ZFA:0000505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "area dorsalis telencephali" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "dorsal part of telencephalon" . [] oboInOwl:hasDbXref "ZFA:0000505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "dorsal telencephalic area" . [] oboInOwl:hasDbXref "ZFA:0000505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000203 ; owl:annotatedTarget "dorsal telencephalon" . [] oboInOwl:notes "separated by cell-free region" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget _:genid111808 . [] oboInOwl:hasDbXref "GO:0021544", "GO_REF:0000021", "ISBN:0471888893", "PMID:12626695" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "Ventral part (base region) of the telencephalon." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "BTO term refers specifically to the avian structure" . [] oboInOwl:hasDbXref "ZFA:0000304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "area ventralis telencephali" . [] oboInOwl:hasDbXref "GO:0021544", "ZFA:0000304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "subpallium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "methylbutyrate esterase inhibitor" . [] oboInOwl:hasDbXref "ZFA:0000304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "ventral telencephalon" . [] oboInOwl:hasDbXref "BTO:0003401", "NCBITaxon:8782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000204 ; owl:annotatedTarget "subpallium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget obo:UBERON_0010428 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget _:genid111818 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000107", "PMID:7914451", "Wikipedia:Frontal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "The bone forming the forehead and roof of the eye orbit." . _:genid111757 oboInOwl:source "ncithesaurus:Frontal_Bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "UMLS:C0016732" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000232 . [] oboInOwl:hasDbXref "AAO:0000206" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "frontal" . [] oboInOwl:hasDbXref "FMA:52734", "MA:0001466" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "frontal bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "methylbutyrate esterase inhibitors" . _:genid111760 oboInOwl:hasDbXref "Wikipedia:Frontal_bone" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "os frontal" ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002049 . [] oboInOwl:hasDbXref "Wikipedia:Frontal_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000209 ; owl:annotatedTarget "os frontale" . _:genid111762 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0001703, obo:UBERON_0006596 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget obo:UBERON_0010428 . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget _:genid111829 . [] oboInOwl:hasDbXref "Wikipedia:Parietal_bone", "ZFA:0000514" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "In humans: bone forming side and roof of cranium. Each bone is irregularly quadrilateral in form, and has two surfaces, four borders, and four angles." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001326" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-3899370805 Arratia G, Schultze HP, Wilson MVH, Mesozoic Fishes 4 - Homology and Phylogeny (2008) p.23-48", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "The homologization of cranial bones of actinopterygians with those of sarcopterygians based on the bone names established in human anatomy is favored in order to permit the building of phylogenetic relationship schemes beyond the taxonomic boundaries of osteichthyans (including tetrapods). (...) In actinopterygians, the terms parietal and postparietal bones have to replace the commonly used terms 'frontal' and 'parietal' bones for the two paired bones on the skull roof.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "The frontal bone in teleost fish is the homolog of the parietal bone in tetrapods[various]. In many non-mammalian tetrapods, they are bordered to the rear by a pair of postparietal bones that may be solely in the roof of the skull, or slope downwards to contribute to the back of the skull, depending on the species. In the living tuatara, and many fossil species, a small opening, the parietal foramen, lies between the two parietal bones. This opening is the location of a third eye in the midline of the skull, which is much smaller than the two main eyes" . [] oboInOwl:source "ncithesaurus:Parietal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "UMLS:C0030558" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "monobutyrase inhibitor" . [] oboInOwl:hasDbXref "TAO:0000514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "actinopterygian frontal bone" . [] oboInOwl:hasDbXref "TAO:0000514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "frontal bone" . [] oboInOwl:hasDbXref "AAO:0000390" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "parietal" . [] oboInOwl:hasDbXref "FMA:9613" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "parietal bone" . [] oboInOwl:hasDbXref "Wikipedia:Parietal_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000210 ; owl:annotatedTarget "os parietale" . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000073", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." . [] oboInOwl:source "FMA:21496" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001682" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "Portion of connective tissue that connects bone or cartilage.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001272" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:8710894 Ohno S, The notion of the Cambrian pananimalia genome. PNAS (1996)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "monobutyrase inhibitors" . _:genid111780 oboInOwl:source "ncithesaurus:Ligament" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "UMLS:C0023685" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004413 . [] oboInOwl:hasDbXref "FMA:21496" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000211 ; owl:annotatedTarget "ligament organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000218 ; owl:annotatedTarget "A neural arch that is part of a vertebral bone 2." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "nonspecific carboxylesterase inhibitor" . [] oboInOwl:hasDbXref "Wikipedia:Atlas_(anatomy)#Vertebral_foramen" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000219 ; owl:annotatedTarget "." . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget _:genid111865 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Hexadecanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "nonspecific carboxylesterase inhibitors" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-occipital_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." . [] oboInOwl:source "ncithesaurus:Atlanto-occipital_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget "UMLS:C0004169" . [] oboInOwl:hasDbXref "FMA:24939" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget "articulatio atlanto-occipitalis" . [] oboInOwl:hasDbXref "FMA:24939" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget "craniovertebral joint" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-occipital_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000220 ; owl:annotatedTarget "articulatio atlantooccipitalis" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget obo:UBERON_0011144 . [] oboInOwl:notes "pubic body just below the pubic crest" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget _:genid111874 . _:genid111808 oboInOwl:notes "linea aspera" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget _:genid111876 ; owl:onProperty obo:BSPO_0000098 ; owl:someValuesFrom obo:UBERON_0000203 . [] oboInOwl:hasDbXref "Wikipedia:Adductor_longus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget "An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "procaine esterase inhibitor" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010034" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget "Originates on the iliac portion of the ventral iliac rim and inserts on the lateral surface of the M. adductor magnus.[AAO]" . [] oboInOwl:external_ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget "definition generalized to accommodate AAO class - 'Originates on the iliac portion of the ventral iliac rim and inserts on the lateral surface of the M. adductor magnus.' [AAO:0010034]" . [] oboInOwl:hasDbXref "BTO:0000029" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget "long adductor muscle" . [] oboInOwl:hasDbXref "BTO:0000029", "Wikipedia:Adductor_longus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000303 ; owl:annotatedTarget "musculus adductor longus" . _:genid111818 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003113, obo:UBERON_0011233 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "procaine esterase inhibitors" . [] oboInOwl:hasDbXref "Wikipedia:Tendon_sheath" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000304 ; owl:annotatedTarget "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." . [] oboInOwl:source "ncithesaurus:Tendon_Sheath" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000304 ; owl:annotatedTarget "UMLS:C0224856" . [] oboInOwl:hasDbXref "FMA:45087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000304 ; owl:annotatedTarget "synovial tendon sheath" . [] oboInOwl:hasDbXref "Wikipedia:Tendon_sheath" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000304 ; owl:annotatedTarget "vagina tendinis" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget _:genid111895 . [] oboInOwl:source "ISBN:0073040584-table5.4" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget _:genid111898 . _:genid111829 oboInOwl:source "ISBN:0073040584-table5.4" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget _:genid111900 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "propionyl esterase inhibitor" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0005029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000721" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget "A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000721" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Amnion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget "UMLS:C0002630" . [] oboInOwl:hasDbXref "http://placentation.ucsd.edu/glossfs.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000305 ; owl:annotatedTarget "amnios" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "propionyl esterase inhibitors" . [] oboInOwl:hasDbXref "Wikipedia:Blastula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000307 ; owl:annotatedTarget "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." . [] oboInOwl:hasDbXref "BILA:0000059" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000307 ; owl:annotatedTarget "blastula embryo" . [] oboInOwl:hasDbXref "Wikipedia:Blastula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000307 ; owl:annotatedTarget "blastosphere" . [] oboInOwl:hasDbXref "MP:0003385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000309 ; owl:annotatedTarget "The external portion of an animal body derived from ectoderm and mesoderm layers that encloses the body cavity." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000309 ; owl:annotatedTarget "the BTO class refers to earthworms." . [] oboInOwl:hasDbXref "FMA:10427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000309 ; owl:annotatedTarget "wall fo trunk" . [] oboInOwl:hasDbXref "FMA:10427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000309 ; owl:annotatedTarget "trunk wall" . [] oboInOwl:hasDbXref "FMA:10427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000309 ; owl:annotatedTarget "wall of trunk" . [] oboInOwl:hasDbXref "Wikipedia:Breast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "The upper ventral region of the torso of an organism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "serine esterase inhibitor" . [] oboInOwl:source "WP,unvetted" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's." . [] oboInOwl:source "ncithesaurus:Breast" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "UMLS:C0006141" . [] oboInOwl:hasDbXref "FMA:9601" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "mammary part of chest" . [] oboInOwl:hasDbXref "FMA:9601" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "mammary region" . [] oboInOwl:hasDbXref "Wikipedia:Breast" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000310 ; owl:annotatedTarget "mamma" . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/extensor+muscle", "https://github.com/obophenotype/uberon/issues/57" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000311 ; owl:annotatedTarget "A skeletal muscle whose contraction extends or stretches a body part." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "serine esterase inhibitors" . [] oboInOwl:hasDbXref "Dorlands_Medical_Dictionary:MerckSource" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000313 ; owl:annotatedTarget "Cartilage pertaining to the tibia." . [] oboInOwl:hasDbXref "FMA:33923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000313 ; owl:annotatedTarget "cartilage of tibia" . (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002361 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002362 ] ) . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "triacetin esterase inhibitor" . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget _:genid111944 . [] oboInOwl:hasDbXref "GOC:add", "Wikipedia:Subarachnoid_space", "https://sourceforge.net/p/obo/mammalian-phenotype-requests/1168/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "The space between the arachnoid and pia mater." . _:genid111874 oboInOwl:hasDbXref "FMA:322060" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "subarachnoid space of neuraxis" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001275 . [] oboInOwl:hasDbXref "BTO:0000230" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "cavitas subarachnoidea" . _:genid111876 oboInOwl:hasDbXref "Wikipedia:Subarachnoid_space" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "cavum subarachnoideale" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000981 . [] oboInOwl:hasDbXref "BTO:0000230" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "spatium leptomeningeum" . [] oboInOwl:hasDbXref "BTO:0000230", "Wikipedia:Subarachnoid_space" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "spatium subarachnoideum" . [] oboInOwl:hasDbXref "BTO:0000230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000315 ; owl:annotatedTarget "subarachnoid cavity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "triacetin esterase inhibitors" . [] oboInOwl:hasDbXref "BTO:0000242", "Wikipedia:Cervix#Cervical_mucus", "Wikipedia:Mucus#Reproductive_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000316 ; owl:annotatedTarget "A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000316 ; owl:annotatedTarget "cervix mucus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "vitamin A esterase inhibitor" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." . [] oboInOwl:hasDbXref "FMA:14984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "colon mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "colon mucous membrane" . [] oboInOwl:hasDbXref "FMA:14984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "colonic mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "large bowel mucosa" . _:genid111895 oboInOwl:hasDbXref "FMA:14984" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "mucosa of colon" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005971 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000317 ; owl:annotatedTarget "mucosa of large bowel" . (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Hexadecylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78444 ; owl:annotatedTarget "vitamin A esterase inhibitors" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "A mucosa that is part of a duodenum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "doudenal mucosa" . [] oboInOwl:hasDbXref "FMA:14942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "duodenal mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "mucosa of duodenum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "mucous membrane of duodenum" . [] oboInOwl:hasDbXref "BTO:0000367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000320 ; owl:annotatedTarget "duodenum mucosa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78574 ; owl:annotatedTarget "pyrimidinecarboxylic acids" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." . [] oboInOwl:source "FMA:63919" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "Fetal structure, which is a developmental form of a vertebrate animal at any given time point from 8 weeks of gestation to birth (or hatching). Examples: There is only one fetus[FMA:63919]." . [] oboInOwl:source "ncithesaurus:Fetus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "UMLS:C0015965" . [] oboInOwl:hasDbXref "BTO:0000449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "fetus" . [] oboInOwl:hasDbXref "BTO:0000449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "embryo late growth stage" . [] oboInOwl:hasDbXref "BTO:0000449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000323 ; owl:annotatedTarget "embryo late stage" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000325 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000325 ; owl:annotatedTarget _:genid111991 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000325 ; owl:annotatedTarget "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." . [] oboInOwl:hasDbXref "GO:0030157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000326 ; owl:annotatedTarget "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." . [] oboInOwl:hasDbXref "BTO:0000504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000326 ; owl:annotatedTarget "succus pancreaticus" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_78608 ; owl:annotatedTarget "MetaCyc:Alpha-Amino-Acids" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000328 ; owl:annotatedTarget "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." . [] oboInOwl:hasDbXref "FMA:45653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000328 ; owl:annotatedTarget "wall of gut" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "A mucosa that is part of a ileum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "ileal mucous membrane" . [] oboInOwl:hasDbXref "FMA:14956", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "ileum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "ileum mucosa of organ" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78608 ; owl:annotatedTarget "an alpha-amino acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "ileum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "ileum organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "mucosa of ileum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "mucosa of organ of ileum" . _:genid111944 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "mucous membrane of ileum" ; owl:onProperty obo:RO_0001019 ; owl:someValuesFrom obo:UBERON_0001981 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000331 ; owl:annotatedTarget "organ mucosa of ileum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78616 ; owl:annotatedTarget "carbohydrates and derivatives" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/Yellow+Marrow" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000332 ; owl:annotatedTarget "Bone marrow in which the fat cells predominate in the meshes of the reticular network." . [] oboInOwl:hasDbXref "BTO:0000635" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000332 ; owl:annotatedTarget "medulla ossium flava" . [] oboInOwl:hasDbXref "BTO:0000635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000332 ; owl:annotatedTarget "yellow marrow" . [] oboInOwl:hasDbXref "BTO:0000635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000332 ; owl:annotatedTarget "fat marrow" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78616 ; owl:annotatedTarget "carbohydrates and their derivatives" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "bowel mucosa gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "bowel mucosa of organ gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "bowel mucous membrane gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "bowel organ mucosa gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of bowel mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of bowel mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of bowel mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of bowel organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of intestinal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of intestine mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of intestine mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of intestine mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of intestine organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucosa of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucosa of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucosa of organ of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucosa of organ of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucous membrane of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of mucous membrane of intestine" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_78631 ; owl:annotatedTarget "Reaxys:1283166" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of organ mucosa of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "gland of organ mucosa of intestine" . [] oboInOwl:hasDbXref "FMA:15052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "glandula intestinalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "intestinal mucosa gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "intestine mucosa gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "intestine mucosa of organ gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "intestine mucous membrane gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "intestine organ mucosa gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucosa of bowel gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucosa of intestine gland" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_78631 ; owl:annotatedTarget "3,4-dihydro-2H-chromen-6-ol" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucosa of organ of bowel gland" . _:genid111991 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucosa of organ of intestine gland" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006924 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucous membrane of bowel gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "mucous membrane of intestine gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "organ mucosa of bowel gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000333 ; owl:annotatedTarget "organ mucosa of intestine gland" . [] oboInOwl:hasDbXref "Wikipedia:Mucous_membrane" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Hexadecylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78631 ; owl:annotatedTarget "3,4-dihydrobenzopyran-6-ol" . [] oboInOwl:source "ncithesaurus:Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "UMLS:C0026724" . [] oboInOwl:hasDbXref "FMA:85355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "mucosa of organ" . [] oboInOwl:hasDbXref "FMA:85358" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "mucosa of organ part" . [] oboInOwl:hasDbXref "FMA:85358" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "mucosal region" . [] oboInOwl:hasDbXref "FMA:85355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "mucous membrane" . [] oboInOwl:hasDbXref "FMA:85355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "organ mucosa" . [] oboInOwl:hasDbXref "FMA:85358" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "region of mucosa" . [] oboInOwl:hasDbXref "BTO:0000886", "Wikipedia:Mucous_membrane" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000344 ; owl:annotatedTarget "tunica mucosa" . [] oboInOwl:hasDbXref "Wikipedia:Myelin" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000345 ; owl:annotatedTarget "A dielectric (electrically insulating) material consisting of protein and fat that forms a layer, the myelin sheath, usually around only the axon of a neuron. Myelin is about 40 % water; the dry mass of myelin is about 70 - 85 % lipids and about 15 - 30 % proteins. Some of the proteins that make up myelin are myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The primary lipid of myelin is a glycolipid called galactocerebroside (GalC). The intertwining hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78675 ; owl:annotatedTarget "essential metabolite" . [] oboInOwl:source "http://www1.pbrc.hawaii.edu/~danh/MyelinEvolution/evolution.html" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0000345 ; owl:annotatedTarget obo:NCBITaxon_6681 . [] oboInOwl:hasDbXref "MP:0003871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000347 ; owl:annotatedTarget "The insulating envelope that surrounds nerve fibers or axons." . [] oboInOwl:source "ncithesaurus:Myelin_Sheath" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000347 ; owl:annotatedTarget "UMLS:C0026973" . [] oboInOwl:hasDbXref "BTO:0000900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000347 ; owl:annotatedTarget "medullary sheath" . [] oboInOwl:notes "may be a distinct nerve in teleosts" ; oboInOwl:source "multiple" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget _:genid112092 . [] oboInOwl:hasDbXref "MP:0009798", "Wikipedia:Ophthalmic_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78675 ; owl:annotatedTarget "essential metabolites" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010648" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "Sensory medial ramus of the trigeminal nerve.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001349" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.177", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "The profundus nerve is a distinct nerve only in fishes. (...) In mammals, the profundus nerve is the same as the most rostral (ophthalmic) branch of the trigeminal nerve.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Ophthalmic_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "UMLS:C0029082" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "cranial nerve V, branch V1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "first branch of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "first division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "first division of trigeminal nerve" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "nervus ophthalmicus (V1)" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "nervus ophthalmicus (Va)" . [] oboInOwl:hasDbXref "FMA:52621", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "nervus ophthalmicus [v1]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78675 ; owl:annotatedTarget "fundamental metabolites" . [] oboInOwl:hasDbXref "FMA:52621", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "nervus ophthalmicus [va]" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division [V1]" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division [Va]" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division of trigeminal nerve (V1)" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division of trigeminal nerve (Va)" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic nerve [V1]" . [] oboInOwl:hasDbXref "FMA:52621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic nerve [Va]" . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "opthalmic nerve" . [] oboInOwl:hasDbXref "AAO:0010648" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ramus opthalmicus profundus (ramus V1)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78803 ; owl:annotatedTarget "nematode metabolites" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "rostral branch of trigeminal nerve" . [] oboInOwl:hasDbXref "MA:0001104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "trigeminal V nerve ophthalmic division" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryPo.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ciliary nerve" . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ethmoidal nerve" . [] oboInOwl:hasDbXref "BTO:0000926", "Wikipedia:Ophthalmic_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "ophthalmic division" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "profundal nerve" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryPo.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "profundus" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryPo.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "profundus nerve" . [] oboInOwl:hasDbXref "EMAPA:17800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000348 ; owl:annotatedTarget "trigeminal nerve ophthalmic division" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78804 ; owl:annotatedTarget "C. elegans metabolite" . [] oboInOwl:hasDbXref "BIRNLEX:Limbic_system", "Wikipedia:Limbic_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000349 ; owl:annotatedTarget "A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]." . [] oboInOwl:source "ncithesaurus:Limbic_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000349 ; owl:annotatedTarget "UMLS:C0023715" . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000349 ; owl:annotatedTarget "visceral brain" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget _:genid112128 . [] oboInOwl:notes "C7 in humans" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget _:genid112131 . [] oboInOwl:hasDbXref "Wikipedia:Nuchal_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget "A fibrous membrane, which, in the neck, represents the supraspinal ligaments of the upper vertebrae." . [] oboInOwl:hasDbXref "FMA:13427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget "ligament of neck" . [] oboInOwl:hasDbXref "FMA:13427" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget "ligamentum nuchae" . [] oboInOwl:hasDbXref "NCBITaxon:9895", "Wikipedia:Paddywhack" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000351 ; owl:annotatedTarget "paddywhack" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78804 ; owl:annotatedTarget "C. elegans metabolites" . [] oboInOwl:hasDbXref "Wikipedia:Parenchyma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000353 ; owl:annotatedTarget "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0000353 ; owl:annotatedTarget "Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000353 ; owl:annotatedTarget "the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated" . [] oboInOwl:source "ncithesaurus:Parenchyma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000353 ; owl:annotatedTarget "UMLS:C0933845" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "A mucosa that is part of a pharynx [Automatically generated definition]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78804 ; owl:annotatedTarget "Caenorhabditis elegans metabolites" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "mucosa of organ of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "mucosa of pharynx" . [] oboInOwl:hasDbXref "FMA:55031", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "mucous membrane of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "organ mucosa of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "pharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "pharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "pharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "pharynx organ mucosa" . [] oboInOwl:hasDbXref "FMA:55031", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "tunica mucosa pharyngea" . [] oboInOwl:hasDbXref "BTO:0001047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000355 ; owl:annotatedTarget "mucous membrane of the pharynx" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78840 ; owl:annotatedTarget "olefinic compounds" . [] oboInOwl:hasDbXref "GO:0001824", "Wikipedia:Blastocyst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000358 ; owl:annotatedTarget "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." . [] oboInOwl:source "ncithesaurus:Blastocyst" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000358 ; owl:annotatedTarget "UMLS:C1281743" . [] oboInOwl:hasDbXref "Wikipedia:Blastocyst" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000358 ; owl:annotatedTarget "blastocystis" . [] oboInOwl:hasDbXref "FMA:83041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000358 ; owl:annotatedTarget "blastula" . ( ) . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/red+marrow" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000361 ; owl:annotatedTarget "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." . [] oboInOwl:hasDbXref "BTO:0001160" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000361 ; owl:annotatedTarget "medulla ossium rubra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000361 ; owl:annotatedTarget "parenchymal red marrow" . [] oboInOwl:hasDbXref "BTO:0001160" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000361 ; owl:annotatedTarget "red marrow" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000361 ; owl:annotatedTarget "parenchyma of none marrow marrow" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Hexaectylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_78954 ; owl:annotatedTarget "(omega-1)-hydroxy fatty acids" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:smb", "MP:0003014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "The inner portion of the kidney consisting of the renal pyramids." . [] oboInOwl:source "ncithesaurus:Renal_Medulla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "UMLS:C0022664" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "kidney medulla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "medulla of kidney" . [] oboInOwl:hasDbXref "FMA:74268", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "medulla renalis" . [] oboInOwl:hasDbXref "FMA:74268", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "pyramides renales" . [] oboInOwl:hasDbXref "FMA:86327" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "renal medullae" . [] oboInOwl:hasDbXref "FMA:86327" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "renal medullae set" . [] oboInOwl:hasDbXref "FMA:74268" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "renal pyramids" . [] oboInOwl:hasDbXref "FMA:74268" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "renal pyramids set" . [] oboInOwl:hasDbXref "FMA:74268" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "medullary pyramids" . [] oboInOwl:hasDbXref "BTO:0001167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000362 ; owl:annotatedTarget "renal marrow" . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/flexor+muscle", "https://github.com/obophenotype/uberon/issues/57" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000366 ; owl:annotatedTarget "A skeletal muscle whose contraction bends a joint." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005271" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000366 ; owl:annotatedTarget "A muscle that decreases the angle of a joint.[TAO]" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget _:genid112199 . [] oboInOwl:hasDbXref "Wikipedia:Corpus_striatum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001175" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.ne.04.030181.001505, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.487 Figure 14-10", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget "Thus, certain telencephalic characters - such as the presence of a pallium divided into lateral, dorsal, and medial formations and a subpallium divided into striatum and septum - appear to characterize all vertebrates. They are primitive characters and are homologous among all vertebrates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Corpus_Striatum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget "UMLS:C0010097" . [] oboInOwl:hasDbXref "BTO:0001311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget "striate body" . [] oboInOwl:hasDbXref "BTO:0001311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000369 ; owl:annotatedTarget "striated body" . _:genid112128 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001645, obo:UBERON_0012477 . [] oboInOwl:hasDbXref "MP:0009800", "Wikipedia:Mandibular_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini." . [] oboInOwl:source "ncithesaurus:Inferior_Maxillary_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "UMLS:C0024695" . _:genid112131 oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "inferior maxillary nerve" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002413 . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular division [V3]" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular division [Vc]" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular division of trigeminal nerve [Vc; V3]" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular nerve [V3]" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "mandibular nerve [Vc]" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "nervus mandibularis [Vc; V3]" . [] oboInOwl:hasDbXref "FMA:52996", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "nervus mandibularis [v3]" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "Beilstein:3589907" . [] oboInOwl:hasDbXref "FMA:52996", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "nervus mandibularis [vc]" . [] oboInOwl:hasDbXref "AAO:0010688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "ramus mandibularis (ramus V3)" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "third division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "third division of trigeminal nerve" . [] oboInOwl:hasDbXref "MA:0001101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "trigeminal V nerve mandibular division" . [] oboInOwl:hasDbXref "Wikipedia:Mandibular_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "n. mandibularis" . [] oboInOwl:hasDbXref "BTO:0001375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "nervus mandibularis" . [] oboInOwl:hasDbXref "EMAPA:17798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000375 ; owl:annotatedTarget "trigeminal nerve mandibular division" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "CAS:143-20-4" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget _:genid112230 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "The part of the hindlimb between pelvis and the knee, corresponding to the femur." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000349" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/61" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "Naming conventions for pod terms under discussion within phenoscape group." . [] oboInOwl:source "ncithesaurus:Thigh" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "UMLS:C0039866" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hind limb stylopod" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "Gmelin:344266" . [] oboInOwl:hasDbXref "VHOG:0000349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hind limb stylopodium" . [] oboInOwl:hasDbXref "AAO:0000887" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hind propodium" . [] oboInOwl:hasDbXref "AAO:0000887" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hindlimb propodium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hindlimb stylopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "hindlimb stylopodium" . [] oboInOwl:hasDbXref "FMA:24967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "proximal segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "stylopod of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "stylopod of hindlimb" . [] oboInOwl:hasDbXref "MA:0000052" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "upper leg" . [] oboInOwl:hasDbXref "Wikipedia:Thigh" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000376 ; owl:annotatedTarget "femur" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "Reaxys:3589907" . [] oboInOwl:hasDbXref "MP:0009799", "Wikipedia:Maxillary_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010670" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "Medial ramus (sensory) of the trigeminal nerve.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010670" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary division [V2]" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary division [Vb]" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary division of trigeminal nerve (Vb; V2)" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary nerve [V2]" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "maxillary nerve [Vb]" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "hexadecanoate" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "nervus maxillaris (Vb; V2)" . [] oboInOwl:hasDbXref "FMA:52724", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "nervus maxillaris [v2]" . [] oboInOwl:hasDbXref "FMA:52724", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "nervus maxillaris [vb]" . [] oboInOwl:hasDbXref "AAO:0010670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "ramus maxillaris (ramus V2)" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "second division of fifth cranial nerve" . [] oboInOwl:hasDbXref "FMA:52724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "second division of trigeminal nerve" . [] oboInOwl:hasDbXref "MA:0001103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "trigeminal V nerve maxillary division" . [] oboInOwl:hasDbXref "Wikipedia:Maxillary_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "n. maxillaris" . [] oboInOwl:hasDbXref "BTO:0001378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "nervus maxillaris" . [] oboInOwl:hasDbXref "EMAPA:17799" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000377 ; owl:annotatedTarget "trigeminal nerve maxillary division" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "hexadecanoate" . _:genid112199 oboInOwl:source "FEED:rd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget obo:UBERON_0014892 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002420 . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "PALMITIC ACID" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "(16:0)" . [] oboInOwl:source "FEED:rd", "ISBN:1607950324" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget _:genid112278 . [] oboInOwl:hasDbXref "MP:0004136", "Wikipedia:Muscles_of_tongue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "The muscular portion of the tongue." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001390" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.20587 Kusakabe R, Kuratani S, Evolution and developmental patterning of the vertebrate skeletal muscles: perspectives from the lamprey. Developmental Dynamics (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Tongue_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "UMLS:C0448325" . [] oboInOwl:source "ncithesaurus:Tongue_Skeletal_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "UMLS:C1710437" . [] oboInOwl:hasDbXref "FMA:46689" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "muscle of tongue" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "muscle organ of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "skeletal muscle tissue of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "tongue skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "tongue skeletal muscle tissue" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "1-hexyldecanoate" . [] oboInOwl:hasDbXref "Wikipedia:Muscles_of_tongue" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000378 ; owl:annotatedTarget "musculi linguae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "A mucosa that is part of a respiratory airway." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucosa of organ of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucosa of organ of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucosa of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucosa of windpipe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "1-pentadecanecarboxylate" . [] oboInOwl:hasDbXref "FMA:7471", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucous membrane of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "mucous membrane of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "organ mucosa of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "organ mucosa of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "trachea mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "trachea mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "trachea mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "trachea organ mucosa" . [] oboInOwl:hasDbXref "FMA:7471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "tracheal mucous membrane" . [] oboInOwl:hasDbXref "FMA:7471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "tunica mucosa (tracheae)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "CH3-[CH2]14-COO(-)" . _:genid112230 oboInOwl:hasDbXref "FMA:7471", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "tunica mucosa tracheae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "windpipe mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "windpipe mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "windpipe mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000379 ; owl:annotatedTarget "windpipe organ mucosa" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget obo:UBERON_0001820 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget _:genid112316 . [] oboInOwl:hasDbXref "PMID:18489347", "Wikipedia:Apocrine_sweat_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget "Apocrine sweat glands are sweat glands composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. The ducts of apocrine glands open into the canals of hair follicles. The stimulus for the secretion of apocrine sweat glands is adrenaline, which is a hormone carried in the blood[WP]." . [] oboInOwl:source "http://www.nal.usda.gov/awic/pubs/swine/swine.htm" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget obo:NCBITaxon_9822 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget "EMAPA:37426" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "Hexadecanoic acid, ion(1-)" . [] oboInOwl:source "ncithesaurus:Apocrine_Sweat_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget "UMLS:C0930083" . [] oboInOwl:hasDbXref "Wikipedia:Apocrine_sweat_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000382 ; owl:annotatedTarget "glandula sudorifera apocrina" . [] oboInOwl:hasDbXref "VSAO:0000033" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000033" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "Anatomical system that consists of the muscles of the body.[VSAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "n-hexadecanoate" . [] oboInOwl:hasDbXref "FMA:72954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "muscular system" . [] oboInOwl:hasDbXref "BILA:0000088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "musculature system" . [] oboInOwl:hasDbXref "FMA:72954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "set of all muscles" . [] oboInOwl:hasDbXref "FMA:72954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "set of muscles of body" . [] oboInOwl:hasDbXref "BTO:0001369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "vertebrate muscular system" . [] oboInOwl:hasDbXref "BTO:0001485" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000383 ; owl:annotatedTarget "muskelsystem" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000388 ; owl:annotatedTarget _:genid112340 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "n-hexadecoate" . [] oboInOwl:hasDbXref "MGI:llw2", "MP:0010371", "Wikipedia:Epiglottis", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000388 ; owl:annotatedTarget "A part of the pharynx that consists of a flap of elastic cartilage tissue plus a mucous membrane covering, attached to the entrance of the larynx. The epiglottis is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink[MP,modified]." . [] oboInOwl:source "ncithesaurus:Epiglottis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000388 ; owl:annotatedTarget "UMLS:C0014540" . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/lens+cortex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000389 ; owl:annotatedTarget "Tissue that surrounds the lens nucleus." . [] oboInOwl:hasDbXref "FMA:58970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000389 ; owl:annotatedTarget "cortex of lens" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "palmitate" . [] oboInOwl:hasDbXref "BTO:0001633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000390 ; owl:annotatedTarget "The core of the crystalline lens, surrounded by the cortex." . [] oboInOwl:hasDbXref "FMA:58971" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000390 ; owl:annotatedTarget "nucleus of lens" . _:genid112278 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0005594, obo:UBERON_0007646 . [] oboInOwl:hasDbXref "Wikipedia:Leptomeninges", "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "Pia mater or arachnoid mater." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_7896 ; owl:annotatedTarget "pentadecanecarboxylate" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "in FMA/NIF this is a superclass of PM/AM - in BTO it is the mereological sum. We go with superclass here, as we are naming the class in the singular" . [] oboInOwl:source "ncithesaurus:Leptomeninges" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "UMLS:C0228126" . [] oboInOwl:hasDbXref "NLXANAT:090207" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "leptomeninges" . [] oboInOwl:hasDbXref "FMA:231515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "arachnoid mater and pia mater" . [] oboInOwl:hasDbXref "BTO:0001634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "arachnoidea mater et pia mater" . [] oboInOwl:hasDbXref "BTO:0001634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "pia-arachnoid" . [] oboInOwl:hasDbXref "FMA:231515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000391 ; owl:annotatedTarget "pia-arachnoid of neuraxis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79020 ; owl:annotatedTarget "2,3-unsaturated monocarboxylic acid" . [] oboInOwl:notes "cell bodies" ; oboInOwl:source "BTO-modified", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget _:genid112375 . [] oboInOwl:hasDbXref "MP:0002855", "http://www.dartmouth.edu/~humananatomy/part_8/chapter_44.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus." . [] oboInOwl:hasDbXref "FMA:53445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "Corti's ganglion" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "cochlear part of vestibulocochlear ganglion" . [] oboInOwl:hasDbXref "FMA:53445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "ganglion of Corti" . [] oboInOwl:hasDbXref "FMA:53445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "spiral ganglion" . [] oboInOwl:hasDbXref "MA:0001085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "vestibulocochlear VIII ganglion cochlear component" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Palmitate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79020 ; owl:annotatedTarget "2,3-unsaturated monocarboxylic acids" . [] oboInOwl:hasDbXref "BTO:0001688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "ganglion cochlearis" . [] oboInOwl:hasDbXref "Wikipedia:Spiral_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "ganglion spirale" . [] oboInOwl:hasDbXref "BTO:0001688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "ganglion spirale cochleae" . [] oboInOwl:hasDbXref "BTO:0001688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "spiral ganglion of cochlea" . [] oboInOwl:hasDbXref "EMAPA:17572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000395 ; owl:annotatedTarget "vestibulocochlear ganglion cochlear component" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "An epithelium that is part of a colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79020 ; owl:annotatedTarget "alpha,beta-unsaturated monocarboxylic acids" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005128" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "Intestinal epithelium which lines the lumen of the posterior intestine.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "colon epithelial tissue" . [] oboInOwl:hasDbXref "FMA:17302", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "colon epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "epithelial tissue of colon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "epithelial tissue of large bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "epithelium of colon" . _:genid112316 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "epithelium of large bowel" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "large bowel epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "large bowel epithelium" . [] oboInOwl:hasDbXref "ZFA:0005128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000397 ; owl:annotatedTarget "posterior intestine epithelium" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000398 ; owl:annotatedTarget "Any portion of cartilage tissue that is part of the sternum." . [] oboInOwl:hasDbXref "FMA:32567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000398 ; owl:annotatedTarget "cartilage of sternum" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79026 ; owl:annotatedTarget "molybdenum cofactor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "A mucosa that is part of a jejunum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "jejunal mucous membrane" . [] oboInOwl:hasDbXref "FMA:14949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "jejunum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "jejunum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "jejunum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "jejunum organ mucosa" . [] oboInOwl:hasDbXref "FMA:14949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "mucosa of jejunum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "mucosa of organ of jejunum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "mucous membrane of jejunum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000399 ; owl:annotatedTarget "organ mucosa of jejunum" . _:genid112340 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002115 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003115 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000400 ; owl:annotatedTarget obo:UBERON_0001902 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000400 ; owl:annotatedTarget _:genid112428 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000400 ; owl:annotatedTarget "An epithelium that is part of a jejunum." . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "The upturned perpendicular extremity of the mandible." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_79209 ; owl:annotatedTarget "PMID:1601877" . [] oboInOwl:hasDbXref "MA:0002815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "mandible ramus" . [] oboInOwl:hasDbXref "FMA:52828" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "ramus of mandible" . [] oboInOwl:hasDbXref "Wikipedia:Ramus_of_the_mandible" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "lower ramus" . [] oboInOwl:hasDbXref "Wikipedia:Ramus_of_the_mandible" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "rami mandibulae" . [] oboInOwl:hasDbXref "Wikipedia:Ramus_of_the_mandible" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000401 ; owl:annotatedTarget "ramus mandibulae" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_vestibule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000402 ; owl:annotatedTarget "The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted]." . [] oboInOwl:hasDbXref "FMA:59644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000402 ; owl:annotatedTarget "vestibular part of nasal cavity" . [] oboInOwl:hasDbXref "BTO:0001761" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000402 ; owl:annotatedTarget "vestibulum nasale" . [] oboInOwl:hasDbXref "BTO:0001761", "Wikipedia:Nasal_vestibule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000402 ; owl:annotatedTarget "vestibulum nasi" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_79209 ; owl:annotatedTarget "PMID:8643456" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000403 ; owl:annotatedTarget _:genid112444 . [] oboInOwl:hasDbXref "MESH:A01.456.810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000403 ; owl:annotatedTarget "The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000403 ; owl:annotatedTarget "EMAPA:37949" . [] oboInOwl:source "ncithesaurus:Scalp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000403 ; owl:annotatedTarget "UMLS:C0036270" . [] oboInOwl:hasDbXref "Wikipedia:Scalp" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000403 ; owl:annotatedTarget "scalpus" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79209 ; owl:annotatedTarget "ganglioside GM3" . _:genid112375 a owl:Restriction ; owl:onProperty obo:RO_0001025, obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0006723, obo:UBERON_0007794 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000409 ; owl:annotatedTarget "A gland in which the principal secretory cells are serous secreting cells." . [] oboInOwl:source "MP:0008052" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000409 ; owl:annotatedTarget "glands that secrete watery albuminous material that often contains enzymes[MP:0008052]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000409 ; owl:annotatedTarget "EMAPA:37950" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "A mucosa that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchi mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchi mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchi mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchi organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchial trunk mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchial trunk mucosa of organ" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_79210 ; owl:annotatedTarget "PMID:1601877" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchial trunk mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchial trunk organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "bronchus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of organ of bronchi" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Palmitic acid" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_79210 ; owl:annotatedTarget "PMID:8643456" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of organ of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucosa of organ of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucous membrane of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucous membrane of bronchial trunk" . [] oboInOwl:hasDbXref "FMA:62652", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "mucous membrane of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "organ mucosa of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "organ mucosa of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "organ mucosa of bronchus" . [] oboInOwl:hasDbXref "FMA:62652", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000410 ; owl:annotatedTarget "tunica mucosa bronchi" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79210 ; owl:annotatedTarget "ganglioside GM3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000414 ; owl:annotatedTarget "A gland in which the principal secretory cells are mucus secreting cells." . [] oboInOwl:hasScope "NCBITaxon:8292" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000414 ; owl:annotatedTarget "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000414 ; owl:annotatedTarget "EMAPA:37913" . [] oboInOwl:hasDbXref "Wikipedia:Mucous_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000414 ; owl:annotatedTarget "glandula mucosa" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79210 ; owl:annotatedTarget "ganglioside GM3(1-)" . [] oboInOwl:hasDbXref "BTO:0001979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000414 ; owl:annotatedTarget "muciparous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000415 ; owl:annotatedTarget "An anatomical wall that is part of an artery [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000415 ; owl:annotatedTarget "arterial wall" . [] oboInOwl:hasDbXref "FMA:14155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000415 ; owl:annotatedTarget "wall of artery" . _:genid112428 oboInOwl:source "MGI:anna" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget obo:UBERON_0010243 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008343 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget _:genid112514 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79346 ; owl:annotatedTarget "ganglioside anion" . [] oboInOwl:hasDbXref "Wikipedia:Eccrine_sweat_gland", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget "A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion." . [] oboInOwl:source "ncithesaurus:Eccrine_Sweat_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget "UMLS:C0013492" . [] oboInOwl:hasDbXref "Wikipedia:Eccrine_sweat_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget "glandula sudorifera eccrina" . [] oboInOwl:hasDbXref "Wikipedia:Eccrine_sweat_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget "glandula sudorifera merocrina" . [] oboInOwl:hasDbXref "FMA:59154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000423 ; owl:annotatedTarget "eccrine gland" . [] oboInOwl:hasDbXref "MP:0001168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "The prostate epithelium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79387 ; owl:annotatedTarget "trivalent inorganic anions" . [] oboInOwl:source "ncithesaurus:Prostatic_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "UMLS:C1179826" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "epithelial tissue of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "epithelial tissue of prostate gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "epithelium of prostate" . _:genid112444 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "epithelium of prostate gland" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 . [] oboInOwl:hasDbXref "FMA:79643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "epithelium of prostatic gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "prostate epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "prostate gland epithelial tissue" . [] oboInOwl:hasDbXref "FMA:66812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000428 ; owl:annotatedTarget "prostatic epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79388 ; owl:annotatedTarget "divalent inorganic anions" . [] oboInOwl:hasDbXref "BTO:0002437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies." . [] oboInOwl:hasDbXref "FMA:77597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "enteric nerve plexus" . [] oboInOwl:hasDbXref "MA:0001147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "intrinsic nerve plexus" . [] oboInOwl:hasDbXref "BTO:0002437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "plexus entericus" . [] oboInOwl:hasDbXref "FMA:77597", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "plexus nervosus entericus" . [] oboInOwl:hasDbXref "FMA:77597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000429 ; owl:annotatedTarget "sympathetic enteric nerve plexus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_79389 ; owl:annotatedTarget "monovalent inorganic anions" . [] oboInOwl:hasDbXref "Wikipedia:Arachnoid_trabeculae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000439 ; owl:annotatedTarget "The arachnoid trabeculae are delicate strands of connective tissue that loosely connect the two innermost layers of the meninges -- the arachnoid mater and the pia mater. They are found within the subarachnoid space where cerebrospinal fluid is also found. Embryologically, the trabeculae are the remnants of the common precursor that forms both the arachnoid and pial layers of the meninges." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000439 ; owl:annotatedTarget "arachnoid trabeculae" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000439 ; owl:annotatedTarget "trabecula arachnoideum" . [] oboInOwl:hasDbXref "GO:0060343", "Wikipedia:Trabecula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000440 ; owl:annotatedTarget "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_81568 ; owl:annotatedTarget "CAS:9002-67-9" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000440 ; owl:annotatedTarget "trabeculae" . [] oboInOwl:hasDbXref "Dorlands_Medical_Dictionary:MerckSource" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "A vein that drains the left pampiniform plexus and empties into the left renal vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "EMAPA:37383" . [] oboInOwl:hasDbXref "MA:0002220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "right spermatic vein" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_81568 ; owl:annotatedTarget "ICSH" . [] oboInOwl:hasDbXref "FMA:14341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "vena testicularis (adrenalis) dextra" . [] oboInOwl:hasDbXref "BTO:0002679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "vena testicularis dextra" . [] oboInOwl:hasDbXref "BTO:0002680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000442 ; owl:annotatedTarget "vena testicularis sinistra" . [] oboInOwl:hasDbXref "Dorlands_Medical_Dictionary:MerckSource" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000443 ; owl:annotatedTarget "A vein that drains the right pampiniform plexus and empties into the inferior vena cava." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_81568 ; owl:annotatedTarget "Interstitial cell stimulating hormone" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000443 ; owl:annotatedTarget "EMAPA:37167" . [] oboInOwl:hasDbXref "MA:0002219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000443 ; owl:annotatedTarget "left spermatic vein" . [] oboInOwl:hasDbXref "BTO:0002679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000443 ; owl:annotatedTarget "vena testicularis dextra" . [] oboInOwl:hasDbXref "BTO:0002680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000443 ; owl:annotatedTarget "vena testicularis sinistra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget obo:UBERON_0001744 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/6", "https://github.com/obophenotype/uberon/issues/7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "." . [] oboInOwl:source "ncithesaurus:Lymphoid_Follicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "UMLS:C0229654" . [] oboInOwl:hasDbXref "FMA:55222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "nodular lymphoid tissue" . [] oboInOwl:hasDbXref "BTO:0002684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "folliculus lymphaticus" . [] oboInOwl:hasDbXref "BTO:0002684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "lymphatic follicle" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Palmitinic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_81568 ; owl:annotatedTarget "LH" . [] oboInOwl:hasDbXref "BTO:0002684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "lymphatic nodule" . [] oboInOwl:hasDbXref "FMA:55222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "lymphoid nodule" . [] oboInOwl:hasDbXref "BTO:0002684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "nodulus lymphaticus" . [] oboInOwl:hasDbXref "BTO:0002684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000444 ; owl:annotatedTarget "nodulus lymphoideus" . [] oboInOwl:hasDbXref "BIRNLEX:963" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996)." . [] oboInOwl:source "FMA:61842" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "Subdivision of the telencephalon on the midline between the lateral ventricles which contains the septum pellucidum and the septal nuclei[FMA][FMA:61842]." . [] oboInOwl:hasDbXref "PMID:23375746" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "Se" . [] oboInOwl:hasDbXref "BIRNLEX:963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septum" . [] oboInOwl:source "BIRNLEX:963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "UMLS:C0752060" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83038 ; owl:annotatedTarget "Daphnia galeata metabolites" . [] oboInOwl:source "BIRNLEX:963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "neuronames:255" . [] oboInOwl:hasDbXref "FMA:61842", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "area septalis" . [] oboInOwl:hasDbXref "FMA:61842" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septal area" . [] oboInOwl:hasDbXref "FMA:61842" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septum (NN)" . _:genid112514 oboInOwl:hasDbXref "FMA:61842" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "telencephalon septum" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . [] oboInOwl:hasDbXref "NeuroNames:255" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "massa praecommissuralis" . [] oboInOwl:hasDbXref "BAMS:SEP" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septal region" . [] oboInOwl:hasDbXref "NeuroNames:255" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septum pellucidum (BNA,PNA)" . [] oboInOwl:hasDbXref "NeuroNames:255" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000446 ; owl:annotatedTarget "septum telencephali" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83039 ; owl:annotatedTarget "crustacean metabolites" . [] oboInOwl:hasDbXref "ncithesaurus:Cerebral_Subcortex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000454 ; owl:annotatedTarget "The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain." . [] oboInOwl:source "ncithesaurus:Cerebral_Subcortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000454 ; owl:annotatedTarget "UMLS:C0815008" . [] oboInOwl:hasDbXref "FMA:242188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000454 ; owl:annotatedTarget "cerebral medulla" . [] oboInOwl:hasDbXref "BTO:0002858" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000454 ; owl:annotatedTarget "subcortex" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "A portion of organism substance that is produced by exocrine glands." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83056 ; owl:annotatedTarget "Daphnia magna metabolites" . [] oboInOwl:hasDbXref "FMA:9675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "secretion" . [] oboInOwl:source "ncithesaurus:Exocrine_Gland_Fluid_or_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "UMLS:C1516992" . [] oboInOwl:hasDbXref "MESH:D012634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "bodily secretion" . [] oboInOwl:hasDbXref "MA:0002504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "exocrine gland fluid/secretion" . [] oboInOwl:hasDbXref "BTO:0002977" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000456 ; owl:annotatedTarget "external secretion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83057 ; owl:annotatedTarget "Daphnia metabolites" . [] oboInOwl:hasDbXref "BTO:0002996" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000457 ; owl:annotatedTarget "Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses." . [] oboInOwl:hasDbXref "FMA:70527" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000457 ; owl:annotatedTarget "cavernous branch of cavernous part of internal carotid artery" . [] oboInOwl:hasDbXref "FMA:70527", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000457 ; owl:annotatedTarget "ramus sinus cavernosi (pars cavernosa) (arteria carotis interna)" . [] oboInOwl:hasDbXref "BTO:0003002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000458 ; owl:annotatedTarget "The region of the opening of the uterine cervix into the uterine cavity." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83563 ; owl:annotatedTarget "a long-chain alkane" . [] oboInOwl:source "ncithesaurus:Endocervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000458 ; owl:annotatedTarget "UMLS:C0227837" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000459 ; owl:annotatedTarget "An anatomical wall that is part of a uterus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000459 ; owl:annotatedTarget "anatomical wall of uterus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000459 ; owl:annotatedTarget "uterus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000459 ; owl:annotatedTarget "uterus wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000459 ; owl:annotatedTarget "wall of uterus" . [] oboInOwl:notes "this relationship may be too strong and may be weakened in future" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget _:genid112647 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." . [] oboInOwl:hasDbXref "MA:0002450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "body fluid or substance" . [] oboInOwl:hasDbXref "FMA:9669" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "body substance" . [] oboInOwl:hasDbXref "CARO:0000004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "organism substance" . [] oboInOwl:hasDbXref "FMA:9669" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "portion of body substance" . [] oboInOwl:hasDbXref "ZFA:0001487" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000463 ; owl:annotatedTarget "portion of organism substance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "canonical amino acid derivative" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000464 ; owl:annotatedTarget "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." . [] oboInOwl:source "ncithesaurus:Lumen_Space" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000464 ; owl:annotatedTarget "UMLS:C0524461" . [] oboInOwl:hasDbXref "ZFA:0001643" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000464 ; owl:annotatedTarget "anatomical spaces" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000465 ; owl:annotatedTarget "Anatomical entity that has mass." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000466 ; owl:annotatedTarget "Anatomical entity that has no mass." . [] oboInOwl:hasDbXref "FMA:67112" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000466 ; owl:annotatedTarget "immaterial physical anatomical entity" . [] oboInOwl:hasDbXref "CARO:0000011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." . [] oboInOwl:hasDbXref "GO:0048731" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "system" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "canonical amino acid derivatives" . [] oboInOwl:source "ncithesaurus:Organ_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "UMLS:C0460002" . [] oboInOwl:hasDbXref "BIRNLEX:14" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "body system" . [] oboInOwl:hasDbXref "CARO:0000011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "connected anatomical system" . [] oboInOwl:hasDbXref "ZFA:0001439" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000467 ; owl:annotatedTarget "anatomical systems" . [] oboInOwl:hasDbXref "CARO:0000012", "Wikipedia:Multi-cellular_organism", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "Anatomical structure that is an individual member of a species and consists of more than one cell." . [] oboInOwl:hasDbXref "FBbt:00000001", "VHOG:0000671", "WBbt:0007833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "organism" . [] oboInOwl:hasDbXref "CARO:0000012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "multi-cellular organism" . [] oboInOwl:hasDbXref "BTO:0001489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "Koerper" . [] oboInOwl:hasDbXref "AEO:0000103", "BIRNLEX:18", "FMA:256135", "NCIT:C13041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "body" . [] oboInOwl:hasDbXref "BTO:0001489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "whole body" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "canonical amino-acid derivative" . [] oboInOwl:hasDbXref "FBbt:00000001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000468 ; owl:annotatedTarget "whole organism" . [] oboInOwl:hasDbXref "CARO:0000019", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000471 ; owl:annotatedTarget "Multi-tissue structure that is part of a compound organ." . [] oboInOwl:hasDbXref "ZFA:0001489" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000471 ; owl:annotatedTarget "compound organ components" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "A gonad of a male animal. A gonad produces and releases sperm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Palmitinsaeure" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "canonical amino-acid derivatives" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000598" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "Male reproductive organ.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000252" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" . [] oboInOwl:source "ISBN:0123971756" ; oboInOwl:taxon "NCBITaxon:40674" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "The testes are descended in metatherian and eutherian mammals, first transabdominally, then inguinoscrotally" . [] oboInOwl:source "ncithesaurus:Testis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "UMLS:C0039597" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "gonad of male genitalia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "gonad of male reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "male gonad" . [] oboInOwl:hasDbXref "FMA:7210" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "testicle" . [] oboInOwl:hasDbXref "BTO:0001363" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "orchis" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "testes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "proteinogenic amino acid derivatives" . [] oboInOwl:hasDbXref "BTO:0001363" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000473 ; owl:annotatedTarget "testiculus" . [] oboInOwl:hasDbXref "MP:0001119", "Wikipedia:Female_genitalia", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "The organs and associated structures associated with bearing offspring in a female animal." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000726" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Female_Reproductive_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "UMLS:C0700038" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "female organism genitalia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "proteinogenic amino-acid derivative" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "female organism reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "genitalia of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "reproductive system of female organism" . [] oboInOwl:hasDbXref "XAO:0000156" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "female genitals" . [] oboInOwl:hasDbXref "MA:0000381" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "female reproductive tract" . [] oboInOwl:hasDbXref "BTO:0000083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "gynaecological tissue" . [] oboInOwl:hasDbXref "BTO:0000083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000474 ; owl:annotatedTarget "systema genitale femininum" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget obo:UBERON_0010000 . [] oboInOwl:hasDbXref "CARO:0000032", "CARO:DOS", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83811 ; owl:annotatedTarget "proteinogenic amino-acid derivatives" . [] oboInOwl:source "ncithesaurus:Body_Part" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget "UMLS:C0229962" . [] oboInOwl:hasDbXref "MA:0002433" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget "anatomic region" . [] oboInOwl:hasDbXref "FMA:7153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget "body region" . [] oboInOwl:hasDbXref "FMA:7153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000475 ; owl:annotatedTarget "cardinal body part" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0000476 ; owl:annotatedTarget obo:UBERON_0010000 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000476 ; owl:annotatedTarget "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." . [] oboInOwl:hasDbXref "ZFA:0000382" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000476 ; owl:annotatedTarget "acellular anatomical structures" . [] oboInOwl:hasDbXref "FBbt:00007277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000477 ; owl:annotatedTarget "Anatomical group whose component anatomical structures lie in close proximity to each other." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83812 ; owl:annotatedTarget "non-canonical amino acid derivative" . [] oboInOwl:hasDbXref "CARO:DOS", "http://orcid.org/0000-0001-9114-8737", "https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000478 ; owl:annotatedTarget "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." . [] oboInOwl:source "ncithesaurus:Extraembryonic_Structure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000478 ; owl:annotatedTarget "UMLS:C1282438" . [] oboInOwl:hasDbXref "ZFA:0000020" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000478 ; owl:annotatedTarget "extraembryonic structures" . _:genid112647 oboInOwl:source "CARO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000479 ; owl:annotatedTarget obo:UBERON_0010000 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 . [] oboInOwl:hasDbXref "CARO:0000043" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000479 ; owl:annotatedTarget "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." . [] oboInOwl:source "ncithesaurus:Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000479 ; owl:annotatedTarget "UMLS:C0040300" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83812 ; owl:annotatedTarget "non-canonical amino-acid derivatives" . [] oboInOwl:hasDbXref "CARO:0000043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000479 ; owl:annotatedTarget "portion of tissue" . [] oboInOwl:hasDbXref "AEO:0000043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000479 ; owl:annotatedTarget "simple tissue" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000481 ; owl:annotatedTarget obo:UBERON_0010000 . [] oboInOwl:hasDbXref "CARO:0000055", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000481 ; owl:annotatedTarget "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." . [] oboInOwl:hasDbXref "ZFA:0001488" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000481 ; owl:annotatedTarget "multi-tissue structures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83812 ; owl:annotatedTarget "non-proteinogenic amino-acid derivatives" . [] oboInOwl:hasDbXref "Wikipedia:Epithelium", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000483 ; owl:annotatedTarget "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000387" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000483 ; owl:annotatedTarget "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000483 ; owl:annotatedTarget "UMLS:C0014609" . [] oboInOwl:hasDbXref "FMA:9639" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000483 ; owl:annotatedTarget "portion of epithelium" . [] oboInOwl:hasDbXref "Wikipedia:Simple_cuboidal_epithelium", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000484 ; owl:annotatedTarget "Unilaminar epithelium that consists of a single layer of cuboidal cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83813 ; owl:annotatedTarget "canonical amino acid" . [] oboInOwl:source "ncithesaurus:Simple_Cuboidal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000484 ; owl:annotatedTarget "UMLS:C0836134" . [] oboInOwl:hasDbXref "ZFA:0001497" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000484 ; owl:annotatedTarget "simple cuboidal epithelia" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Simple_columnar_epithelium", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000485 ; owl:annotatedTarget "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." . [] oboInOwl:hasDbXref "EHDAA2:0003068" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000485 ; owl:annotatedTarget "columnar epithelium" . [] oboInOwl:hasDbXref "AEO:0000068" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000485 ; owl:annotatedTarget "columnar epithlium" . [] oboInOwl:source "ncithesaurus:Simple_Columnar_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000485 ; owl:annotatedTarget "UMLS:C0836135" . [] oboInOwl:hasDbXref "ZFA:0001496" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000485 ; owl:annotatedTarget "simple columnar epithelia" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Stratified_epithelium", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000486 ; owl:annotatedTarget "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "CARO:0000069" ; oboInOwl:ontology "CARO" ; oboInOwl:source "FMA:45562", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000486 ; owl:annotatedTarget "Epithelium that consists of more than one layer of epithelial cells.[CARO]" . [] oboInOwl:source "ncithesaurus:Stratified_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000486 ; owl:annotatedTarget "UMLS:C0682575" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83813 ; owl:annotatedTarget "canonical amino acids" . [] oboInOwl:hasDbXref "BTO:0002074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000486 ; owl:annotatedTarget "laminated epithelium" . [] oboInOwl:hasDbXref "FMA:45565", "Wikipedia:Simple_squamous_epithelium", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000487 ; owl:annotatedTarget "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "CARO:0000070" ; oboInOwl:ontology "CARO" ; oboInOwl:source "FMA:45565", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000487 ; owl:annotatedTarget "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" . [] oboInOwl:source "ncithesaurus:Simple_Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000487 ; owl:annotatedTarget "UMLS:C0836133" . [] oboInOwl:hasDbXref "ZFA:0001498" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000487 ; owl:annotatedTarget "simple squamous epithelia" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000488 ; owl:annotatedTarget "Epithelium that consists of epithelial cells not arranged in one ore more layers." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83813 ; owl:annotatedTarget "proteinogenic amino acids" . [] oboInOwl:hasDbXref "ZFA:0001493" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000488 ; owl:annotatedTarget "atypical epithelia" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000489 ; owl:annotatedTarget "Compound organ that contains one or more macroscopic anatomical spaces." . [] oboInOwl:hasDbXref "FMA:55671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000489 ; owl:annotatedTarget "cavitated organ" . [] oboInOwl:hasDbXref "ZFA:0001490" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000489 ; owl:annotatedTarget "cavitated compound organs" . [] oboInOwl:hasDbXref "FMA:45561", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000490 ; owl:annotatedTarget "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "CARO:0000073" ; oboInOwl:ontology "CARO" ; oboInOwl:source "FMA:45561", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000490 ; owl:annotatedTarget "Epithelium that consists of a single layer of epithelial cells.[CARO]" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "Pentadecanecarboxylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-canonical amino acid" . [] oboInOwl:source "ncithesaurus:Simple_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000490 ; owl:annotatedTarget "UMLS:C0682574" . [] oboInOwl:hasDbXref "FMA:45561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000490 ; owl:annotatedTarget "simple epithelium" . [] oboInOwl:hasDbXref "ZFA:0001495" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000490 ; owl:annotatedTarget "unilaminar epithelia" . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget obo:UBERON_0008841 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget _:genid112795 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget _:genid112797 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-canonical amino acids" . [] oboInOwl:hasDbXref "Wikipedia:Suspensory_muscle_of_duodenum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "A thin muscle connecting the junction between the duodenum, jejunum, and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery." . [] oboInOwl:hasDbXref "FMA:20509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "ligament of Treitz" . [] oboInOwl:hasDbXref "FMA:20509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "muscle of Treitz" . [] oboInOwl:hasDbXref "FMA:20509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "musculus suspensorius duodeni" . [] oboInOwl:hasDbXref "FMA:20509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "suspensory muscle of duodenum" . [] oboInOwl:hasDbXref "Wikipedia:Suspensory_muscle_of_duodenum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000642 ; owl:annotatedTarget "musculus suspensorius duodeni" . [] oboInOwl:hasDbXref "Wikipedia:Mucus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000912 ; owl:annotatedTarget "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-canonical amino-acid" . [] oboInOwl:source "ncithesaurus:Mucus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000912 ; owl:annotatedTarget "UMLS:C0026727" . [] oboInOwl:hasDbXref "Wikipedia:Interstitial_fluid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000913 ; owl:annotatedTarget "Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid." . [] oboInOwl:hasDbXref "ENVO:02000042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000913 ; owl:annotatedTarget "intercellular fluid" . [] oboInOwl:hasDbXref "ENVO:02000042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000913 ; owl:annotatedTarget "tissue fluid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-canonical amino-acids" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000915 ; owl:annotatedTarget obo:UBERON_0009569 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000915 ; owl:annotatedTarget "Subdivision of trunk that lies between the head and the abdomen." . [] oboInOwl:hasDbXref "MA:0000022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000915 ; owl:annotatedTarget "thorax" . [] oboInOwl:hasDbXref "FMA:259209" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000915 ; owl:annotatedTarget "upper trunk" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000916 ; owl:annotatedTarget _:genid112823 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000916 ; owl:annotatedTarget "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." . [] oboInOwl:hasDbXref "FMA:9577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000916 ; owl:annotatedTarget "abdominopelvic region" . [] oboInOwl:hasDbXref "FMA:9577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000916 ; owl:annotatedTarget "abdominopelvis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-coded amino acid" . [] oboInOwl:hasDbXref "BTO:0000379", "FB:FBrf0039741", "FB:FBrf0041814", "GO:0009790", "Wikipedia:Embryo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000922 ; owl:annotatedTarget "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000922 ; owl:annotatedTarget "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" . [] oboInOwl:source "ncithesaurus:Embryo" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000922 ; owl:annotatedTarget "UMLS:C0013935" . [] oboInOwl:hasDbXref "BILA:0000056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000922 ; owl:annotatedTarget "embryonic organism" . [] oboInOwl:hasDbXref "BILA:0000056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000922 ; owl:annotatedTarget "developing organism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-coded amino acids" . [] oboInOwl:hasDbXref "Wikipedia:Germ_layer", "https://github.com/obophenotype/uberon/issues/203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001223" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:69069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "embryonic tissue" . [] oboInOwl:source "ncithesaurus:Embryonic_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "UMLS:C0920502" . [] oboInOwl:source "ncithesaurus:Germinal_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "UMLS:C1708239" . [] oboInOwl:hasDbXref "ncithesaurus:Germinal_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "germinal layer" . [] oboInOwl:hasDbXref "GO:0001704", "ZFA:0001122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000923 ; owl:annotatedTarget "primary germ layer" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget _:genid112849 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-coded amino-acid" . [] oboInOwl:hasDbXref "Wikipedia:Ectoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000137" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000153" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Ectoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget "UMLS:C0013574" . [] oboInOwl:hasDbXref "VHOG:0000153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000924 ; owl:annotatedTarget "embryonic ectoderm" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000925 ; owl:annotatedTarget _:genid112857 . [] oboInOwl:hasDbXref "Wikipedia:Endoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000925 ; owl:annotatedTarget "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000154" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000925 ; owl:annotatedTarget "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Endoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000925 ; owl:annotatedTarget "UMLS:C0014144" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-coded amino-acids" . [] oboInOwl:hasDbXref "DOI:10.5962/bhl.title.1013" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000925 ; owl:annotatedTarget "entoderm" . [] oboInOwl:notes "sometimes not considered primary" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget obo:UBERON_0000923 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget _:genid112865 . [] oboInOwl:hasDbXref "Wikipedia:Mesoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "The middle germ layer of the embryo, between the endoderm and ectoderm." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000304" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000152" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" . [] oboInOwl:source "ncithesaurus:Mesoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "UMLS:C0025485" . [] oboInOwl:hasDbXref "VHOG:0000152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "embryonic mesoderm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-proteinogenic amino acids" . [] oboInOwl:hasDbXref "SCTID:362854004", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000926 ; owl:annotatedTarget "entire mesoderm" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_part_of_vagus_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "Motor nerve of the pharynx, arises from the upper part of the ganglion nodosum, and consists principally of filaments from the cranial portion of the accessory nerve." . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "pharyngeal branch" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "pharyngeal branch of inferior vagal ganglion" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "pharyngeal branch of vagus" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "ramus pharyngealis nervi vagalis" . [] oboInOwl:hasDbXref "FMA:6234", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "ramus pharyngeus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-proteinogenic amino-acid" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "tenth cranial nerve pharyngeal branch" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "vagal pharyngeal branch" . [] oboInOwl:hasDbXref "FMA:6234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "vagus nerve pharyngeal branch" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_part_of_vagus_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000929 ; owl:annotatedTarget "ramus pharyngeus nervi vagi" . _:genid112795 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001103, obo:UBERON_0035804 . [] oboInOwl:hasDbXref "Wikipedia:Stomodeum", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." . _:genid112797 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001290" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002114 . [] oboInOwl:source "MP:0012522" ; oboInOwl:taxon "NCBITaxon:40674" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" . [] oboInOwl:hasDbXref "XAO:0000269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "stomodeal-hypophyseal primordium" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "cetylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83820 ; owl:annotatedTarget "non-proteinogenic amino-acids" . [] oboInOwl:source "ncithesaurus:Stomodeum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "UMLS:C1514977" . [] oboInOwl:hasDbXref "XAO:0000269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "mouth primordium" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "primitive oral cavity" . [] oboInOwl:hasDbXref "Wikipedia:Stomodeum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "stomatodeum" . [] oboInOwl:hasDbXref "EMAPA:16263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "mouth pit" . [] oboInOwl:hasDbXref "ZFA:0001290", "ZFIN:ZDB-PUB-100726-23" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "oral ectoderm" . [] oboInOwl:hasDbXref "EMAPA:16263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000930 ; owl:annotatedTarget "oral pit" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83821 ; owl:annotatedTarget "amino acid derivatives" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget obo:UBERON_0016566 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget _:genid112902 . [] oboInOwl:hasDbXref "ZFA:0000066", "https://github.com/obophenotype/uberon/issues/685", "https://sourceforge.net/p/fbbtdv/tickets/52" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000066" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "An inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011087" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ZFA:0000066" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "Inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[AAO]" . [] oboInOwl:source "ncithesaurus:Proctodeum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "UMLS:C0231054" . [] oboInOwl:hasDbXref "FBbt:00000123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "amnioproctodeal invagination" . [] oboInOwl:hasDbXref "VHOG:0000139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "anal pit" . [] oboInOwl:hasDbXref "XAO:0001019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000931 ; owl:annotatedTarget "anus porus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83821 ; owl:annotatedTarget "modified amino acids" . _:genid112823 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001015, obo:UBERON_0002417 . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_muscles", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "A muscle that acts on the pharynx[WP, vetted]." . [] oboInOwl:date_retrieved "2012-06-30" ; oboInOwl:external_class "GO:0043282" ; oboInOwl:notes "does not quite work for some muscles such as stylopharyngeus" ; oboInOwl:ontology "GO" ; oboInOwl:source "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "A pharyngeal muscle is any muscle that forms part of the pharynx[GO]." . [] oboInOwl:source "ncithesaurus:Pharyngeal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "UMLS:C0031346" . [] oboInOwl:hasDbXref "ZFA:0000172" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "branchial muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "muscle organ of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "pharynx muscle organ" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83822 ; owl:annotatedTarget "non-proteinogenic L-alpha-amino acids" . [] oboInOwl:hasDbXref "TAO:0000172" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "branchial muscles" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "musculi pharyngis" . [] oboInOwl:hasDbXref "BTO:0001048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "musculus pharyngis" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000933 ; owl:annotatedTarget "tunica muscularis pharyngis" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget obo:UBERON_0002473 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget obo:UBERON_0005341 . [] oboInOwl:hasDbXref "BTO:0002169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001558" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1749-6632.1969.tb20432.x", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "In all vertebrates the thin structure that connects the two halves of the telencephalon shows a ridge-like thickening at the basal side known as the anterior commissure.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1557", "ncithesaurus:Anterior_Commissure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "UMLS:C0152335" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "anterior cerebral commissure" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_8386 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02030000" . [] oboInOwl:hasDbXref "NeuroNames:205" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "commissura anterior cerebri" . [] oboInOwl:hasDbXref "NLX:144088" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "AC" . [] oboInOwl:hasDbXref "BAMS:AC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "anterior commissural nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_commissure" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "commissura anterior" . [] oboInOwl:hasDbXref "NeuroNames:205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "paleocortical commissure" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_commisure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "precommisure" . [] oboInOwl:hasDbXref "NeuroNames:205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000935 ; owl:annotatedTarget "rostral commissure" . _:genid112849 a owl:Restriction ; owl:onProperty obo:RO_0002134, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0000966, obo:UBERON_0006601 . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_8386 ; owl:annotatedTarget "pregnane" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget _:genid112949 . _:genid112857 oboInOwl:hasDbXref "ISBN:0471209627", "ISBN:0471888893" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006595 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000435" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "A collection of nerve cells that project visual information from the eyes to the brain. (Source: BioGlossary, www.Biology-Text.com)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010345" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "Fibrous, somatic sensory element covered by a fibrous connective-tissue sheath and is continuous with the layer of nerve cells on the inner surface of the eye.[AAO]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83925 ; owl:annotatedTarget "non-proteinogenic alpha-amino acids" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000543" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429, http://medical-dictionary.thefreedictionary.com/optic+stalk", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup (reference 1); The (optic) stalk persists as the optic nerve (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "(relaion to eye): MA, XAO, AAO and BTO consider this part of the eye. This is in contrast to GO, FMA, EHDAA2 (FMA has a class 'intra-ocular part of optic nerve' which represents the region of overlap). Relation to brain: part of diencephalon in EHDAA2, ZFA. In NIF, has the optic nerve root as part, which is a feature part of the diencphalon" . [] oboInOwl:hasDbXref "BIRNLEX:1640", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "2n" . [] oboInOwl:hasDbXref "FMA:50863", "ZFA:0000435" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "optic nerve" . [] oboInOwl:source "BIRNLEX:1640", "ncithesaurus:Optic_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "UMLS:C0029130" . _:genid112865 oboInOwl:source "BIRNLEX:1640" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "neuronames:289" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006603 . [] oboInOwl:hasDbXref "AAO:0010345" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "02 optic nerve" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "nervus opticus" . [] oboInOwl:hasDbXref "FMA:50863", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "nervus opticus [II]" . [] oboInOwl:hasDbXref "EHDAA2:0001313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "optic II" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83925 ; owl:annotatedTarget "non-proteinogenic alpha-amino-acid" . [] oboInOwl:hasDbXref "EHDAA2:0001313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "optic II nerve" . [] oboInOwl:hasDbXref "ZFA:0000435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "CN-II" . [] oboInOwl:hasDbXref "NeuroNames:289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "nerve II" . [] oboInOwl:hasDbXref "TAO:0000435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000941 ; owl:annotatedTarget "optic" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget obo:UBERON_0010039 . [] oboInOwl:evidence "ISBN:0486692132" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget _:genid112972 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Stomach", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83925 ; owl:annotatedTarget "non-proteinogenic alpha-amino-acids" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget obo:NCBITaxon_7878 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget obo:NCBITaxon_9259 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000579" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000408" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1525-142x.2000.00076.x Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM, Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evolution and development (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]" . [] oboInOwl:source "WP:Stomach#In_other_animals" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa" . [] oboInOwl:source "ncithesaurus:Stomach" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "UMLS:C0038351" . [] oboInOwl:hasDbXref "BTO:0001307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "gaster" . [] oboInOwl:hasDbXref "Wikipedia:Stomach" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000945 ; owl:annotatedTarget "ventriculus" . [] oboInOwl:source "PMID:15797462" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget _:genid112985 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83955 ; owl:annotatedTarget "1,2-saturated fatty acid anion" . [] oboInOwl:hasDbXref "MESH:A07.541.510", "MP:0000285", "PMID:7926784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget "A membranous fold of the heart that prevents reflux of fluid." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000818" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/heart+valve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget "One of the four structures within the heart that prevent backflow of blood by opening and closing with each heartbeat. The valves include two semilunar valves, the aortic and pulmonary; the mitral or bicuspid valve; and the tricuspid valve. The valves permit blood flow in only one direction. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000818" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cardiac_Valve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget "UMLS:C0018826" . [] oboInOwl:hasDbXref "XAO:0004126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000946 ; owl:annotatedTarget "heart valve" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget obo:UBERON_0003509 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget _:genid112993 . [] oboInOwl:source "MA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget _:genid112995 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MESH:A07.231.114.056", "MP:0000272", "Wikipedia:Aorta", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "hexadecoic acid" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83955 ; owl:annotatedTarget "a 1,2-saturated fatty acid" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010213" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]" . _:genid112902 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001523" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0012469 . [] oboInOwl:source "ncithesaurus:Aorta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "UMLS:C0003483" . [] oboInOwl:hasDbXref "Wikipedia:Aorta#In_other_animals", "ZFA:0000014" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "dorsal aorta" . [] oboInOwl:hasDbXref "Wikipedia:Aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000947 ; owl:annotatedTarget "arteria maxima" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83972 ; owl:annotatedTarget "3-methyl fatty acid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget _:genid113009 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget _:genid113012 . [] oboInOwl:hasDbXref "Wikipedia:Heart", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000114" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010210" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010210" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000276" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "UMLS:C0018787" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83972 ; owl:annotatedTarget "3-methyl-branched fatty acid anion" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "chambered heart" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "branchial heart" . [] oboInOwl:hasDbXref "EMAPA:16105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000948 ; owl:annotatedTarget "cardium" . [] oboInOwl:hasDbXref "NLM:endocrine+system", "Wikipedia:Endocrine_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000949 ; owl:annotatedTarget "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83972 ; owl:annotatedTarget "3-methyl-branched fatty acid(1-)" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010279" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000949 ; owl:annotatedTarget "Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000098" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000949 ; owl:annotatedTarget "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Endocrine_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000949 ; owl:annotatedTarget "UMLS:C0014136" . [] oboInOwl:hasDbXref "EHDAA2:0002224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000949 ; owl:annotatedTarget "endocrine glandular system" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/rotator+muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000951 ; owl:annotatedTarget "Any of a number of short transversospinal muscles chiefly developed in cervical, lumbar, and thoracic regions, arising from the transverse process of one vertebra and inserted into the root of the spinous process of the next two or three vertebrae above, with nerve supply from the dorsal branches of the spinal nerve, and whose actions rotate the vertebral column." . [] oboInOwl:hasDbXref "FMA:23081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000951 ; owl:annotatedTarget "rotator muscle" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget obo:UBERON_0000062 . _:genid112949 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget _:genid113046 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003902 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_83982 ; owl:annotatedTarget "L-glutamic acid derivatives" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget _:genid113052 . [] oboInOwl:hasDbXref "Wikipedia:Brain", "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000008" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010478" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]" . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000157" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:796", "ncithesaurus:Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "UMLS:C0006104" . [] oboInOwl:source "BIRNLEX:796" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "UMLS:C1269537" . [] oboInOwl:source "BIRNLEX:796" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "neuronames:21" . [] oboInOwl:hasDbXref "BTO:0000142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "encephalon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84087 ; owl:annotatedTarget "human urinary metabolites" . [] oboInOwl:hasDbXref "NeuroNames:21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "suprasegmental levels of nervous system" . [] oboInOwl:hasDbXref "NeuroNames:21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "suprasegmental structures" . [] oboInOwl:hasDbXref "NeuroNames:21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000955 ; owl:annotatedTarget "the brain" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget obo:UBERON_0016548 . [] oboInOwl:source "GO", "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget _:genid113067 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget _:genid113069 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget _:genid113071 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "PMID:24362891" . [] oboInOwl:hasDbXref "BIRNLEX:1494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." . [] oboInOwl:source "Wikipedia:Cerebral_cortex" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]." . _:genid112972 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000722" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1749-6632.1969.tb20437.x Kruger L, Experimental analyses of the reptilian nervous system. Annals of the New York Academy of Sciences (1969)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]" ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001696 . [] oboInOwl:source "BIRNLEX:1494", "ncithesaurus:Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "UMLS:C0007776" . [] oboInOwl:source "BIRNLEX:1494" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "neuronames:39" . [] oboInOwl:hasDbXref "BTO:0000233", "FMA:61830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "cortex of cerebral hemisphere" . [] oboInOwl:hasDbXref "BTO:0000233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "brain cortex" . [] oboInOwl:hasDbXref "NeuroNames:39" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "cortex cerebralis" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_cortex" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "cortex cerebri" . [] oboInOwl:hasDbXref "NeuroNames:39" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "cortical plate (CTXpl)" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "(2S,3R,4E)-3-hydroxy-2-[(15Z)-tetracos-15-enoylamino]octadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside" . [] oboInOwl:hasDbXref "NeuroNames:39" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "cortical plate (areas)" . [] oboInOwl:hasDbXref "BTO:0000233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000956 ; owl:annotatedTarget "pallium of the brain" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Lamina_of_the_vertebral_arch" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000957 ; owl:annotatedTarget "Any thin layer or plate." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000958 ; owl:annotatedTarget "Middle part of an organ, surrounded by the cortex." . [] oboInOwl:hasDbXref "FMA:61108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000958 ; owl:annotatedTarget "medulla" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "G(M3) ganglioside" . ( ) . ( ) . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget obo:UBERON_0007418 . [] oboInOwl:hasDbXref "MGI:llw2", "MP:0009770", "Wikipedia:Optic_chiasm", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "A decussation of the diencephalon where the fibers of the optic nerve cross." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "n-hexadecanoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "GM3" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010622" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:DSM" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "The point at which fibers of the optic nerves cross.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000190" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.preteyeres.2005.04.005 Jeffery G, Erskine L, Variations in the architecture and development of the vertebrate optic chiasm. Progress in retinal and eye research (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" . [] oboInOwl:source "BIRNLEX:1416", "ncithesaurus:Optic_Chiasm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "UMLS:C0029126" . [] oboInOwl:source "BIRNLEX:1416" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "neuronames:459" . [] oboInOwl:hasDbXref "Wikipedia:Optic_chiasm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "chiasma opticum" . [] oboInOwl:hasDbXref "FMA:62045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "decussation of optic nerve fibers" . [] oboInOwl:hasDbXref "Wikipedia:Optic_chiasm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "optic chiasm" . [] oboInOwl:hasDbXref "NeuroNames:459" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "chiasma" . [] oboInOwl:hasDbXref "NeuroNames:459" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "chiasma nervorum opticorum" . _:genid113009 oboInOwl:hasDbXref "NeuroNames:459" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000959 ; owl:annotatedTarget "optic chiasm (Rufus of Ephesus)" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015410 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "NANA-Gal-Glc-ceramide" . _:genid113012 a owl:Restriction ; owl:onProperty obo:RO_0002254, core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002342, obo:UBERON_0002726 . [] oboInOwl:hasDbXref "Wikipedia:Cervical_nerves" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000962 ; owl:annotatedTarget "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Cervical_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000962 ; owl:annotatedTarget "UMLS:C0228815" . [] oboInOwl:hasDbXref "FMA:5859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000962 ; owl:annotatedTarget "cervical nerve" . [] oboInOwl:hasDbXref "FMA:5859", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000962 ; owl:annotatedTarget "nervus cervicalis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-(15Z)-tetracos-15-enoylsphingosine" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget _:genid113124 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget _:genid113126 . [] oboInOwl:source "FMA-isa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget _:genid113128 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget _:genid113134 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MESH:A09.371.060.217", "MP:0001312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-cis-tetracos-15-enoylsphingosine" . [] oboInOwl:source "ncithesaurus:Cornea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget "UMLS:C0010031" . [] oboInOwl:hasDbXref "GO:0061303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget "cornea of camera-type eye" . [] oboInOwl:hasDbXref "ZFA:0000640" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000964 ; owl:annotatedTarget "corneas" . [] oboInOwl:hasDbXref "Wikipedia:Lens_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000169" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "monosialodihexosylganglioside" . [] oboInOwl:source "ncithesaurus:Crystalline_Lens" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "UMLS:C0023317" . [] oboInOwl:hasDbXref "GO:0002088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "camera-type eye lens" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "eye lens" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "lens" . [] oboInOwl:hasDbXref "Wikipedia:Lens_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "lens crystallina" . [] oboInOwl:hasDbXref "BTO:0000723", "PMID:36055924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "crystalline lens" . _:genid113046 oboInOwl:hasDbXref "ZFA:0000035" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "lenses" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001017 . [] oboInOwl:hasDbXref "BTO:0000723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000965 ; owl:annotatedTarget "ocular lens" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84118 ; owl:annotatedTarget "monosialoganglioside GM3" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget _:genid113160 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget _:genid113162 . _:genid113052 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget _:genid113164 ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006238 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget _:genid113166 . [] oboInOwl:hasDbXref "Wikipedia:Retina", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000152" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000229" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1153", "ncithesaurus:Retina" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "UMLS:C0035298" . [] oboInOwl:source "BIRNLEX:1153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "UMLS:C1278894" . [] oboInOwl:hasDbXref "GO:0060041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "retina of camera-type eye" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_84125 ; owl:annotatedTarget "PMID:24362891" . [] oboInOwl:hasDbXref "BTO:0001175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "Netzhaut" . [] oboInOwl:hasDbXref "ZFA:0000152" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000966 ; owl:annotatedTarget "retinas" . [] oboInOwl:source "PMID:21062451" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000970 ; owl:annotatedTarget _:genid113177 . [] oboInOwl:source "PMID:21062451" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000970 ; owl:annotatedTarget _:genid113179 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000970 ; owl:annotatedTarget "An organ that detects light." . _:genid113067 oboInOwl:hasDbXref "EV:0100336" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000970 ; owl:annotatedTarget "visual apparatus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000203 . _:genid113069 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005401, obo:UBERON_0007811 . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_84125 ; owl:annotatedTarget "(15Z)-N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide" . _:genid113071 a owl:Restriction ; owl:onProperty obo:RO_0002216, core:posteriorly_connected_to ; owl:someValuesFrom obo:GO_0007613, obo:UBERON_0002100 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000974 ; owl:annotatedTarget "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." . [] oboInOwl:source "ncithesaurus:Neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000974 ; owl:annotatedTarget "UMLS:C0027530" . [] oboInOwl:hasDbXref "Wikipedia:Neck" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000974 ; owl:annotatedTarget "collum" . [] oboInOwl:hasDbXref "FMA:7155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000974 ; owl:annotatedTarget "neck (volume)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84125 ; owl:annotatedTarget "(15Z)-N-[(2S,3R,4E)-1-{[N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget obo:UBERON_0010363 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget _:genid113194 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/67" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000765" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "Single element that constitutes the postzonal area of the pectoral girdle.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000765" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "relationship loss: part_of postzonal element (AAO:0000938)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000856" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.294", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "Fishes lack a sternum. (...) A sternum is absent in the first fossil tetrapods, but it is present in modern amphibians. (...) Thus, a sternum occurs in some modern amphibians, birds, mammals and archosaurs. However, its absence in the common ancestors to these groups means that it has arisen independently several times within the field of the midventral connective tissue.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "While its developmental origins are similar to the ribs (from the myospetum and septum of the trunk region), it is often associated with the pectoral skeleton, due to both function and physical connections (i.e. the coracoid of archosaurs). It may be a single element or a series of smaller structure (sternebrae). Based on Kardong 2012. [PHENOSCAPE:ad]." . [] oboInOwl:source "ncithesaurus:Sternum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "UMLS:C0038293" . [] oboInOwl:hasDbXref "BTO:0001302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000975 ; owl:annotatedTarget "breastbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84125 ; owl:annotatedTarget "GalbetaNAcbeta3Galalpha4Galbeta4GlcbetaCer" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget obo:UBERON_0002495 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget _:genid113211 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget _:genid113213 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget _:genid113216 . [] oboInOwl:hasDbXref "AAO:0000679", "PHENOSCAPE:mah", "https://github.com/obophenotype/uberon/issues/106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah]." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "n-hexadecoic acid" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84125 ; owl:annotatedTarget "globoside Gb4Cer(d18:1(4E)/24:1(15Z))" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000679" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "Paired, elongate, cylindrical bones of endochondral origin that extend from the pectoral girdle to the elbows.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001158" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "UMLS:C0020164" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "humeri" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "mesomere 1 of pectoral appendage" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "proximal metapterygial mesomere of pectoral appendage" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000976 ; owl:annotatedTarget "proximal metapterygial mesomere of pectoral fin" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000977 ; owl:annotatedTarget _:genid113236 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84185 ; owl:annotatedTarget "D-proline derivatives" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010820", "UBERON:cjm", "Wikipedia:Pulmonary_pleurae", "https://github.com/obophenotype/uberon/issues/1231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000977 ; owl:annotatedTarget "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000394" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:0124020607", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000977 ; owl:annotatedTarget "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" . [] oboInOwl:source "ncithesaurus:Pleural_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000977 ; owl:annotatedTarget "UMLS:C0032225" . [] oboInOwl:hasDbXref "BTO:0001791", "NCIT:C12469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000977 ; owl:annotatedTarget "pleural tissue" . _:genid113124 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001801, obo:UBERON_0002103 . _:genid113126 a owl:Restriction ; owl:onProperty obo:BFO_0000050, core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001464, obo:UBERON_0010409 . [] oboInOwl:hasDbXref "Wikipedia:Leg#Limb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000978 ; owl:annotatedTarget "The portion of the hindlimb that contains both the stylopod and zeugopod." . _:genid113128 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000345" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000978 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012430 . [] oboInOwl:source "3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0000978 ; owl:annotatedTarget "The term leg can mean: [1] an appendage on which an animal walks [2] the entire hindlimb of a tetrapod [3] the segment of a human leg between knee and ankle (cf FMA) [4] the region of a hindlimb include the stylopod and zeugopod, but excluding the autopod. We define this class as [4], and thus 'leg' is compltely analagous to 'arm'. For [1], see the class 'locomotive weight-bearing appendage'. For [2] we use 'hindlimb'. For" . [] oboInOwl:hasDbXref "MESH:A01.378.610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000978 ; owl:annotatedTarget "lower extremity" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget obo:UBERON_0002495 . [] oboInOwl:hasDbXref "PHENOSCAPE:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget "The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84186 ; owl:annotatedTarget "L-proline derivatives" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000890" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget "One of the two long bones of endochondral origin of the hind-epipodium; it is a straight, simple bone whose section is more or less rectangular at the ends and circular at its central portion.[AAO]" . [] oboInOwl:source "ncithesaurus:Tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget "UMLS:C0040184" . [] oboInOwl:hasDbXref "Wikipedia:Tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget "shankbone" . [] oboInOwl:hasDbXref "Wikipedia:Tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000979 ; owl:annotatedTarget "shinbone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget _:genid113266 . [] oboInOwl:hasDbXref "MP:0004627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget "A bony prominence near the extremity of the femur that normally serves as attachment points for hip and thigh muscles[MP,modified]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000897" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget "Process on the ventral surface of the shaft of the femur.[AAO]" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget "there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third)" . [] oboInOwl:source "ncithesaurus:Trochanter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget "UMLS:C0162370" . [] oboInOwl:hasDbXref "AAO:0000897" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000980 ; owl:annotatedTarget "femoral trochanter" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget obo:UBERON_0008202 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget _:genid113279 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget _:genid113281 . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84196 ; owl:annotatedTarget "a 3-hydroxy fatty acid" . _:genid113160 oboInOwl:evidence "definitional" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget _:genid113283 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000573 . [] oboInOwl:hasDbXref "VSAO:0000186", "Wikipedia:Femur" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified]." . _:genid113162 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000186" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:NI" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium.[VSAO]" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000604 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000889" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "Paired, elongate, cylindrical bones of endochondral origin that form the thighs, extending from the pelvic girdles to the knees.[AAO]" . _:genid113164 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001159" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000740 . [] oboInOwl:source "ncithesaurus:Femur" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "UMLS:C0015811" . _:genid113166 oboInOwl:hasDbXref "BTO:0001284" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "femoral bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003072 . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "mesomere 1 of pevlic appendage" . [] oboInOwl:hasDbXref "BTO:0001284" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "os femorale" . [] oboInOwl:hasDbXref "BTO:0001284" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "os femoris" . [] oboInOwl:hasDbXref "Wikipedia:Femur" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "os longissimum" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "proximal metapterygial mesomere of pelvic appendage" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000981 ; owl:annotatedTarget "proximal metapterygial mesomere of pelvic fin" . _:genid113177 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002176 ; owl:someValuesFrom obo:CL_0000149, obo:UBERON_0004765 . _:genid113179 oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000101", "Wikipedia:Joint", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000210 . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_84497 ; owl:annotatedTarget "(omega-1)-hydroxy fatty acid anion" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000101" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000367" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:pem" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]" . [] oboInOwl:hasDbXref "VSAO:0000101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "articulation" . [] oboInOwl:hasDbXref "FMA:7490", "VSAO:0000101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "joint" . [] oboInOwl:source "ncithesaurus:Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "UMLS:C0022417" . [] oboInOwl:hasDbXref "BTO:0001686" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "articular joint" . [] oboInOwl:hasDbXref "ZFA:0001596" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000982 ; owl:annotatedTarget "joints" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84497 ; owl:annotatedTarget "an (omega-1)-hydroxy fatty acid" . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget _:genid113316 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "A metapodium region that is part of a pes." . _:genid113194 oboInOwl:hasDbXref "AAO:0000221", "MA:th", "http://en.wiktionary.org/wiki/metapodial" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "hind metapodium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003252 . [] oboInOwl:hasDbXref "FMA:24997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "metatarsal part of foot" . [] oboInOwl:hasDbXref "FMA:24997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "metatarsal region" . [] oboInOwl:hasDbXref "FMA:24997", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "regio metatarsalis" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "hindlimb cannon region" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "hindlimb equine cannon region" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15756 ; owl:annotatedTarget "palmitic acid" . [] oboInOwl:hasDbXref "MA:0000049" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000983 ; owl:annotatedTarget "metatarsus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000985 ; owl:annotatedTarget "Vein that drains the axilla." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000985 ; owl:annotatedTarget "In human anatomy, the axillary vein is a large blood vessel that conveys blood from the lateral aspect of the thorax, axilla (armpit) and upper limb toward the heart. There is one axillary vein on each side of the body. Its origin is at the lower margin of the teres major muscle and a continuation of the brachial vein. Its tributaries include the basilic vein and cephalic vein, which are both superficial veins. It terminates at the lateral margin of the first rib, at which it becomes the subclavian vein. It is accompanied along its course by a similarly named artery, the axillary artery" . [] oboInOwl:source "ncithesaurus:Axillary_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000985 ; owl:annotatedTarget "UMLS:C0004456" . [] oboInOwl:hasDbXref "Wikipedia:Axillary_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000985 ; owl:annotatedTarget "vena axillaris" . _:genid113211 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440, obo:UBERON_0002298 . _:genid113213 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002298, obo:UBERON_0003822 . [] oboInOwl:source "neuronames" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget _:genid113337 . [] oboInOwl:hasDbXref "VHOG:0001176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." . _:genid113216 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001176" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pons" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006245 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001176" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.474", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:733", "ncithesaurus:Pons_Varolii" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "UMLS:C0032639" . [] oboInOwl:source "BIRNLEX:733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "UMLS:C1280999" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_84690 ; owl:annotatedTarget "LIPID_MAPS_instance:LMSP0502AA02" . [] oboInOwl:source "BIRNLEX:733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "neuronames:547" . [] oboInOwl:hasDbXref "ncithesaurus:Pons_Varolii" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "pons Varolii" . [] oboInOwl:hasDbXref "NeuroNames:547" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000988 ; owl:annotatedTarget "pons cerebri" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget obo:UBERON_0008811 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget _:genid113351 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget _:genid113353 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005187", "Wikipedia:Penis", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget "An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget "Most male birds (e.g., roosters and turkeys) have a cloaca (also present on the female), but not a penis. Among bird species with a penis are paleognathes (tinamous and ratites), Anatidae (ducks, geese and swans), and a very few other species (such as flamingoes). A bird penis is different in structure from mammal penises, being an erectile expansion of the cloacal wall and being erected by lymph, not blood. It is usually partially feathered and in some species features spines and brush-like filaments, and in flaccid state curls up inside the cloaca" . [] oboInOwl:source "ncithesaurus:Penis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget "UMLS:C0030851" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000989 ; owl:annotatedTarget "penes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_84690 ; owl:annotatedTarget "N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]octadecanamide" . _:genid113236 oboInOwl:hasDbXref "Wikipedia:Reproductive_system" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "Anatomical system that has as its parts the organs concerned with reproduction." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009778 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010258" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000182" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:21672850 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across Bilateria. Integrative and Comparative Biology (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Reproductive_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "UMLS:C1261210" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84690 ; owl:annotatedTarget "Gb3(d18:1/18:0)" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "genitalia" . [] oboInOwl:hasDbXref "BTO:0000081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "Geschlechtsorgan" . [] oboInOwl:hasDbXref "BTO:0000081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "animal reproductive system" . [] oboInOwl:hasDbXref "BTO:0000081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "organa genitalia" . [] oboInOwl:hasDbXref "BTO:0000081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "reproductive tissue" . [] oboInOwl:hasDbXref "Wikipedia:Reproductive_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000990 ; owl:annotatedTarget "systemata genitalia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84735 ; owl:annotatedTarget "algal metabolites" . [] oboInOwl:hasDbXref "ISBN:0140512888", "Wikipedia:Gonad", "ZFA:0000413", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000213" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000413" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000397" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "FMA xref is a 'general anatomical term'" . [] oboInOwl:source "ncithesaurus:Gonad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "UMLS:C0018067" . [] oboInOwl:hasDbXref "ZFA:0000413" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000991 ; owl:annotatedTarget "gonads" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001126", "Wikipedia:Ovary" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "The gonad of a female organism which contains germ cells." . _:genid113266 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000371" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000403" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "Female reproductive organ.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000251" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_84981 ; owl:annotatedTarget "2-aminohexanedioate" . [] oboInOwl:source "ncithesaurus:Ovary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "UMLS:C0029939" . [] oboInOwl:hasDbXref "EFO:0000973" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "animal ovary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female organism genitalia gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female organism genitalia gonada" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female organism reproductive system gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female organism reproductive system gonada" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female reproductive system gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "female reproductive system gonada" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "genitalia of female organism gonad" . _:genid113279 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "genitalia of female organism gonada" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_84981 ; owl:annotatedTarget "alpha-aminoadipate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonad of female organism genitalia" . _:genid113281 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonad of female organism reproductive system" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001441 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonad of female reproductive system" . _:genid113283 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonad of genitalia of female organism" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010129 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonad of reproductive system of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonada of female organism genitalia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonada of female organism reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonada of female reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonada of genitalia of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "gonada of reproductive system of female organism" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "Beilstein:5744307" . [] oboInOwl:hasDbXref "GO:0061039" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "ovum-producing ovary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "reproductive system of female organism gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "reproductive system of female organism gonada" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "ovaries" . [] oboInOwl:hasDbXref "Wikipedia:Ovary" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000992 ; owl:annotatedTarget "ovarium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "A tube or collection of tubes in an animal from the ovaries to the outside of the body." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001136" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/oviduct" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "A passage through which ova leave the maternal body or pass to an organ communicating with the exterior of the body. [TFD][VHOG]" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA03010000" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001136" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.687-688", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "In all remaining vertebrates (i.e., coelacanths, lungfishes, amphibians, reptiles, birds, and mammals), the oviduct arises in ontogeny as a longitudinal, groovelike invagination of the coelomic epithelium on the lateral surface of the mesonephros.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Oviduct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "UMLS:C0029954" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "ovarian duct" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "ovarian tube" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "female reproductive tracts" . [] oboInOwl:hasDbXref "ZFA:0000560" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "oviducts" . [] oboInOwl:hasDbXref "BTO:0000980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "tuba uterina" . [] oboInOwl:hasDbXref "BTO:0000980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "tuba uterinae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000993 ; owl:annotatedTarget "tubular parts of female reproductive system" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "PMID:6234649" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000995 ; owl:annotatedTarget obo:UBERON_0013515 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0001120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000995 ; owl:annotatedTarget "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001137" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/uterus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000995 ; owl:annotatedTarget "The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001137" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.678", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000995 ; owl:annotatedTarget "An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000995 ; owl:annotatedTarget "UMLS:C0042149" . _:genid113316 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0003975, obo:UBERON_0012142 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget obo:UBERON_0013515 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget _:genid113446 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget _:genid113448 . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "Reaxys:5744307" . [] oboInOwl:hasDbXref "Wikipedia:Vagina", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." . [] oboInOwl:date_retrieved "2012-11-29" ; oboInOwl:external_class "FMA:19949" ; oboInOwl:ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina.[FMA]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001138" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/vagina" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "The genital canal in the female, leading from the opening of the vulva to the cervix of the uterus. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001138" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.688", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Vagina" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "UMLS:C0042232" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000996 ; owl:annotatedTarget "vaginae" . [] oboInOwl:hasDbXref "Wikipedia:Vulva" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "External genital organs of the female mammal[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001458" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/vulva" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Vulva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "UMLS:C0042993" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "7-[(1S,2S)-2-octylcyclopentyl]heptanoic acid" . [] oboInOwl:hasDbXref "BTO:0003101", "FMA:20462", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "female pudendum" . [] oboInOwl:hasDbXref "FMA:20462" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "puboperineal region" . [] oboInOwl:hasDbXref "FMA:20462", "FMA:TA", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "pudendum femininum" . [] oboInOwl:hasDbXref "MA:0000395" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "vulva" . [] oboInOwl:hasDbXref "BTO:0003101", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "pudendum" . [] oboInOwl:hasDbXref "Wikipedia:Vulva", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "pudendum femininum" . [] oboInOwl:hasDbXref "BTO:0003101", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000997 ; owl:annotatedTarget "pudendum muliebre" . _:genid113337 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473, obo:UBERON_0001895 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "Prostanoic acid" . [] oboInOwl:hasDbXref "BTO:0001234", "Wikipedia:Seminal_vesicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001379" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/prominence" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "Either of a pair of pouchlike glands situated on each side of the male urinary bladder that secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001379" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.556", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "(In mammalian testis) Along the way (the sperm travel), three accessory sex glands, the seminal vesicle, prostate, and bulbourethral (Cowper's) gland, respectively, add their secretions as sperm move from the testes to the urethra.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Seminal_Vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "UMLS:C0036628" . [] oboInOwl:hasDbXref "BTO:0001234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "glandula seminalis" . [] oboInOwl:hasDbXref "BTO:0001234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "glandula vesiculosa" . [] oboInOwl:hasDbXref "BTO:0001234", "Wikipedia:Seminal_vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesicula seminalis" . [] oboInOwl:hasDbXref "Wikipedia:Seminal_vesicle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesiculae seminales" . [] oboInOwl:hasDbXref "Wikipedia:Seminal_vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesicular gland" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_8504 ; owl:annotatedTarget "prostan-1-oic acid" . [] oboInOwl:hasDbXref "Wikipedia:Seminal_vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesicular glands" . _:genid113351 oboInOwl:hasDbXref "Wikipedia:Seminal_vesicle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesicular seminalis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004876 . [] oboInOwl:hasDbXref "Wikipedia:Seminal_vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000998 ; owl:annotatedTarget "vesiculæ seminales" . _:genid113353 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000079, obo:UBERON_0005876 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_85234 ; owl:annotatedTarget "human blood serum metabolites" . [] oboInOwl:hasDbXref "Wikipedia:Ejaculatory_duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0000999 ; owl:annotatedTarget "The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Ejaculatory_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0000999 ; owl:annotatedTarget "UMLS:C0013747" . [] oboInOwl:hasDbXref "BTO:0001580" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000999 ; owl:annotatedTarget "ductus ejaculatorii" . [] oboInOwl:hasDbXref "BTO:0001580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0000999 ; owl:annotatedTarget "ductus ejaculatorius" . [] oboInOwl:hasDbXref "Wikipedia:Ejaculatory_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0000999 ; owl:annotatedTarget "ductus ejaculatorii" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_85425 ; owl:annotatedTarget "glycine transporter inhibitors" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget _:genid113497 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:pvb", "MP:0002769", "Wikipedia:Vas_deferens", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget "A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001135" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.670", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget "The continuation of the archinephric duct, now called the deferent duct, extends caudally to the cloaca or to the part of the mammalian urethra that is derived from the cloaca.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget "Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm is carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans. In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species. In amniotes, however, the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm. The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall." . [] oboInOwl:source "ncithesaurus:Vas_Deferens" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget "UMLS:C0042360" . [] oboInOwl:hasDbXref "Wikipedia:Vas_deferens" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001000 ; owl:annotatedTarget "ductus deferens" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "anti-fungal drug" . [] oboInOwl:hasDbXref "ISBN:0073040584", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "The outer epithelial layer of the skin that is superficial to the dermis." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000105" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000143" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000143" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "relationship loss: subclass external integument structures (AAO:0000961)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000077" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.71-72", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "(...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Epidermis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001003 ; owl:annotatedTarget "UMLS:C0014520" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "anti-fungal drugs" . [] oboInOwl:hasDbXref "Wikipedia:Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "Functional system which consists of structures involved in respiration." . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget obo:NCBITaxon_147099 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000541" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000202" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Respiratory_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "UMLS:C0035237" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_157668 ; owl:annotatedTarget "carbocyclic fatty acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "anti-fungal medication" . [] oboInOwl:hasDbXref "BTO:0000203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "Atmungssystem" . [] oboInOwl:hasDbXref "BTO:0000203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "apparatus respiratorius" . [] oboInOwl:hasDbXref "Wikipedia:Respiratory_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001004 ; owl:annotatedTarget "systema respiratorium" . [] oboInOwl:hasDbXref "Wikipedia:Trachea" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001005 ; owl:annotatedTarget "An airway through which respiratory air passes in organisms." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001005 ; owl:annotatedTarget "airway" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001005 ; owl:annotatedTarget "airways" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "anti-fungal medications" . [] oboInOwl:hasDbXref "FB:gg", "NLM:alimentary+system", "Wikipedia:Digestive_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001007 ; owl:annotatedTarget "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000129" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001007 ; owl:annotatedTarget "An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001007 ; owl:annotatedTarget "many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "antifungal drugs" . [] oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0099864", "GO:0072001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget obo:NCBITaxon_110815 . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget obo:NCBITaxon_147099 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010257" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000723" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-3540428541 Kapoor BG, Bhavna Khanna, Ichthyology Handbook (2004) p.406", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG]" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels" . [] oboInOwl:source "DOI:10.1371/journal.pone.0099864" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans" . [] oboInOwl:source "ncithesaurus:Urinary_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "UMLS:C1508753" . [] oboInOwl:hasDbXref "FMA:7159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "systema urinaria" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "antifungal medication" . [] oboInOwl:hasDbXref "BTO:0003092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "systema urinarium" . [] oboInOwl:hasDbXref "EHDAA:5901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001008 ; owl:annotatedTarget "renal or urinary system" . [] oboInOwl:hasDbXref "Wikipedia:Circulatory_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001009 ; owl:annotatedTarget "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001009 ; owl:annotatedTarget obo:NCBITaxon_147099 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000959" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001009 ; owl:annotatedTarget "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001248" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.493", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001009 ; owl:annotatedTarget "We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Circulatory_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001009 ; owl:annotatedTarget "systema cardiovasculare" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "antifungal medications" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_ulna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "The body of the ulna at its upper part is prismatic in form, and curved so as to be convex behind and lateralward; its central part is straight; its lower part is rounded, smooth, and bent a little lateralward. It tapers gradually from above downward, and has three borders and three surfaces." . [] oboInOwl:hasDbXref "FMA:33760" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "body of ulna" . [] oboInOwl:hasDbXref "FMA:33760" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "corpus ulnae" . _:genid113446 oboInOwl:hasDbXref "FMA:33760" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "shaft of ulna" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003975 . [] oboInOwl:hasDbXref "FMA:33760" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "ulnar diaphysis" . _:genid113448 oboInOwl:hasDbXref "Wikipedia:Body_of_ulna" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "shaft of ulna" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000164 . [] oboInOwl:hasDbXref "Wikipedia:Body_of_ulna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001010 ; owl:annotatedTarget "supinator crest" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "pharmaceutical fungicide" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget _:genid113583 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget _:genid113585 . [] oboInOwl:hasDbXref "Wikipedia:Head_of_radius" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget "The head of the radius has a cylindrical form, and on its upper surface is a shallow cup or fovea for articulation with the capitulum (or capitellum) of the humerus. The circumference of the head is smooth; it is broad medially where it articulates with the radial notch of the ulna, narrow in the rest of its extent, which is embraced by the annular ligament. The deepest point in the fovea is not axi-symmetric with the long axis of the radius, creating a cam effect during pronation and supination[WP]." . [] oboInOwl:hasDbXref "FMA:33773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget "radial head" . [] oboInOwl:hasDbXref "Wikipedia:Head_of_radius" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001012 ; owl:annotatedTarget "caput radii" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_86327 ; owl:annotatedTarget "pharmaceutical fungicides" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget obo:UBERON_0011822 . [] oboInOwl:hasDbXref "MESH:A10.165.114", "MGI:cwg", "MP:0000003", "Wikipedia:Adipose_tissue", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002134" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "Connective tissue in which fat is stored.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000001" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000001" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001284" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0029665107005423 Haugen F, Drevon CA, The interplay between nutrients and the adipose tissue. The Proceedings of the Nutrition Society (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "in FMA this is dense irregular connective tissue" . [] oboInOwl:source "ncithesaurus:Adipose_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "UMLS:C0001527" . [] oboInOwl:hasDbXref "MA:0000009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "fat" . [] oboInOwl:hasDbXref "BTO:0001487" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "adipose" . [] oboInOwl:hasDbXref "BTO:0001487" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001013 ; owl:annotatedTarget "bodyfat" . [] oboInOwl:hasDbXref "Wikipedia:Muscular_system", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "A subdivision of the muscular system corresponding to a subdisivision of an organism." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." . [] oboInOwl:source "ncithesaurus:Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "UMLS:C0026845" . [] oboInOwl:hasDbXref "FMA:32558", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "musculi" . [] oboInOwl:hasDbXref "FMA:32558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "set of muscles" . [] oboInOwl:hasDbXref "MA:0000165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001015 ; owl:annotatedTarget "set of skeletal muscles" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget _:genid113617 . [] oboInOwl:hasDbXref "BIRNLEX:844", "ISBN:0-14-051288-8", "ISBN:3110148986", "NLM:nervous+system", "WB:rynl", "Wikipedia:Nervous_system", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000396" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000324" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000402" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "UMLS:C0027763" . [] oboInOwl:hasDbXref "GO:0050877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "neurological system" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_86508 ; owl:annotatedTarget "PMID:24023812" . [] oboInOwl:hasDbXref "Wikipedia:Nerve_net" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "nerve net" . [] oboInOwl:hasDbXref "Wikipedia:Nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001016 ; owl:annotatedTarget "systema nervosum" . [] oboInOwl:source "FBbt", "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget _:genid113629 . [] oboInOwl:hasDbXref "GO:0021551", "http://www.frontiersinzoology.com/content/7/1/29", "https://sourceforge.net/p/geneontology/ontology-requests/11422/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget obo:NCBITaxon_147099 . _:genid113497 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000090" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "Part of the nervous system which includes the brain and spinal cord.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005352 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000012" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "The brain and spinal cord. Kimmel et al, 1995.[TAO]" . [] oboInOwl:source "BIRNLEX:1099" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_86508 ; owl:annotatedTarget "2-aminobutanoate" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000293" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 (reference 1), ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 (reference 2), DOI:10.1016/j.cell.2007.02.040 Denes AS, Jekely G, Steinmetz PRH, Raible F, Snyman H, Prud'homme B, Ferrier DEK, Balavoine G and Arendt D, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in Bilateria. Cell (2007) (reference 3)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1099", "ncithesaurus:Central_Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "UMLS:C0927232" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "CNS" . [] oboInOwl:hasDbXref "FMA:55675", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "systema nervosum centrale" . [] oboInOwl:hasDbXref "FMA:55675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "cerebrospinal axis" . [] oboInOwl:hasDbXref "FMA:55675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001017 ; owl:annotatedTarget "neuraxis" . [] oboInOwl:hasDbXref "http://flybrain.uni-freiburg.de/Flybrain/html/terms/terms.html", "https://github.com/obophenotype/uberon/issues/286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001018 ; owl:annotatedTarget "A group of axons linking two or more neuropils and having a common origin, termination[FBbt]." . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001018 ; owl:annotatedTarget "White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. (CUMBO)" . [] oboInOwl:hasDbXref "FMA:83847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001018 ; owl:annotatedTarget "neuraxis tract" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88167 ; owl:annotatedTarget "beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer" . [] oboInOwl:hasDbXref "FMA:83847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001018 ; owl:annotatedTarget "tract of neuraxis" . [] oboInOwl:hasDbXref "BIRNLEX:1649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001018 ; owl:annotatedTarget "nerve tract" . [] oboInOwl:hasDbXref "BIRNLEX:872", "FBbt:00005101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed)." . [] oboInOwl:hasDbXref "FBbt:00005101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "fascicle" . [] oboInOwl:source "ncithesaurus:Fascicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "UMLS:C1185741" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "fasciculus" . [] oboInOwl:hasDbXref "FMA:12235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "nerve bundle" . [] oboInOwl:hasDbXref "FMA:12235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "nerve fasciculus" . [] oboInOwl:hasDbXref "FMA:12235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "neural fasciculus" . [] oboInOwl:hasDbXref "BTO:0002191" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001019 ; owl:annotatedTarget "nerve fiber tract" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88167 ; owl:annotatedTarget "beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer" . [] oboInOwl:hasDbXref "NLXANAT:20090513", "https://github.com/obophenotype/uberon/issues/300", "https://github.com/obophenotype/uberon/issues/325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt]." . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "White matter fiber bundle that crosses the midline of the brain or spinal cord, that connects similar structures on both sides. (CUMBO; Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)" . [] oboInOwl:source "ncithesaurus:Commissure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "UMLS:C1185742" . [] oboInOwl:hasDbXref "FMA:83906" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "commissure of neuraxis" . [] oboInOwl:hasDbXref "FMA:83906" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "neuraxis commissure" . [] oboInOwl:hasDbXref "CUMBO:CUMBO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001020 ; owl:annotatedTarget "white matter commissure" . [] oboInOwl:source "FBbt" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget obo:UBERON_0000122 . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88167 ; owl:annotatedTarget "globoside Gb4Cer" . [] oboInOwl:hasDbXref "FBbt:00005105", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0007009" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "A portion of tissue which is a fasiculated group of axons.[TAO]" . [] oboInOwl:source "ncithesaurus:Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "UMLS:C0027740" . [] oboInOwl:source "ncithesaurus:Peripheral_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "UMLS:C0031119" . [] oboInOwl:hasDbXref "TAO:0007009" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "nerves" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "peripheral nerve" . [] oboInOwl:hasDbXref "FMA:65132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001021 ; owl:annotatedTarget "neural subtree" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001027 ; owl:annotatedTarget _:genid113673 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Sensory_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001027 ; owl:annotatedTarget "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." . [] oboInOwl:hasDbXref "Wikipedia:Sensory_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001027 ; owl:annotatedTarget "nervus sensorius" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Body_of_radius" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "A diaphysis that is part of a radius bone[Automatically generated definition]." . [] oboInOwl:source "Wikipedia:Body_of_radius" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "The body of the radius (or shaft of radius) is prismoid in form, narrower above than below, and slightly curved, so as to be convex lateralward. It presents three borders and three surfaces[Wikipedia:Body_of_radius]." . [] oboInOwl:hasDbXref "FMA:33782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "body of radius" . [] oboInOwl:hasDbXref "FMA:33782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "corpus radii" . [] oboInOwl:hasDbXref "FMA:33782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "radial diaphysis" . [] oboInOwl:hasDbXref "FMA:33782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "shaft of radius" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88184 ; owl:annotatedTarget "allergenic metal" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_radius" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "radial shaft" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_radius" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001028 ; owl:annotatedTarget "shaft of radius" . [] oboInOwl:hasDbXref "Wikipedia:Sensory_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001674" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:75259", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "organa sensuum" . [] oboInOwl:hasDbXref "FMA:75259" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "sense organs" . [] oboInOwl:hasDbXref "FMA:75259" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "sense organs set" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88184 ; owl:annotatedTarget "allergenic metals" . [] oboInOwl:hasDbXref "TAO:0000282" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "sensory systems" . [] oboInOwl:hasDbXref "Wikipedia:Sensory_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "organa sensuum" . [] oboInOwl:hasDbXref "FMA:75259" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001032 ; owl:annotatedTarget "set of sense organs" . [] oboInOwl:hasDbXref "NLXANAT:090803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001033 ; owl:annotatedTarget "The sensory system for the sense of taste." . [] oboInOwl:source "NLXANAT:090803" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001033 ; owl:annotatedTarget "The sensory system for the sense of taste[NLXANAT:090803]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88184 ; owl:annotatedTarget "metal allergens" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010577" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001033 ; owl:annotatedTarget "The sensory system used for the sense of taste.[AAO]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001033 ; owl:annotatedTarget "in ZFA and MA this is a subtype of sensory system. we should change sensory system to disambiguate parts and wholes" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget obo:UBERON_0000021 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget _:genid113710 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget _:genid113712 . [] oboInOwl:hasDbXref "Wikipedia:Hair" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget "A filament, mostly protein, that grows from follicles found in the dermis[WP]." . [] oboInOwl:source "ncithesaurus:Hair" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget "UMLS:C0018494" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget "quill" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_88188 ; owl:annotatedTarget "allergenic drug" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget "vibrissa" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001037 ; owl:annotatedTarget "whisker" . [] oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/635" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget obo:UBERON_0005631 . _:genid113583 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget obo:UBERON_0007499 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001490 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget _:genid113723 . _:genid113585 oboInOwl:source "ISBN:0073040584" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget _:genid113725 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004413 . [] oboInOwl:hasDbXref "Wikipedia:Yolk_sac" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000830" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/yolk+sac" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]" . [] oboInOwl:source "MP:0001718" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000830" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Yolk_Sac" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "UMLS:C0043425" . [] oboInOwl:hasDbXref "Wikipedia:Yolk_sac" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "saccus vitellinus" . [] oboInOwl:hasDbXref "Wikipedia:Yolk_sac" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001040 ; owl:annotatedTarget "vesicula umbilicalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "Anterior subdivision of a digestive tract." . [] oboInOwl:source "MP:0000474" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000285" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Foregut" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "UMLS:C0231051" . [] oboInOwl:hasDbXref "Wikipedia:Foregut" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "praeenteron" . [] oboInOwl:hasDbXref "Wikipedia:Foregut" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001041 ; owl:annotatedTarget "proenteron" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_157750 ; owl:annotatedTarget "heparan sulfate group" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget _:genid113741 . [] oboInOwl:hasDbXref "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." . [] oboInOwl:source "MESH:A03.867" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000967" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "Anatomical cavity bounded by the derivatives of the branchial arches.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000056" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO]" . [] oboInOwl:source "ZFIN:ZDB-PUB-961014-576" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000462" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000967" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000967" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000462" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) Box essay 13.1 and Box figure I, p.502-503", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "(...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme" . [] oboInOwl:hasDbXref "FMA:46688" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "pharynx" . [] oboInOwl:source "ncithesaurus:Pharynx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001042 ; owl:annotatedTarget "UMLS:C0031354" . _:genid113617 oboInOwl:source "FMA", "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget obo:UBERON_0000062 ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0016880 . [] oboInOwl:hasDbXref "Wikipedia:Esophagus", "http://www.rivm.nl/interspeciesinfo/inter/oesophagus/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000145" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "CAS:498-21-5" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000450" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1096-3642.1996.tb01658.x Mallatt J, Ventilation and the origin of jawed vertebrates: a new mouth. Zoological Journal of the Linnean Society (1996)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget "The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget "esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)" . [] oboInOwl:source "ncithesaurus:Esophagus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001043 ; owl:annotatedTarget "UMLS:C0014876" . _:genid113629 a owl:Restriction ; owl:onProperty obo:RO_0002215, obo:RO_0002495 ; owl:someValuesFrom obo:GO_0046541, obo:UBERON_0016879 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "CAS:498-21-5" . [] oboInOwl:hasDbXref "GO:0007431", "Wikipedia:Salivary_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "Saliva-secreting exocrine glands of the oral cavity[GO]." . [] oboInOwl:source "3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "currently we define saliva and salivary glands very generally in functional terms but it may be more appropriate to split this class. From WP: In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000376" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "A gland that produces the saliva. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000376" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptationm(2005) p.211", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "In air-feeding animals, the lack of water column to lubricate the food has been compensated for by the evolution of the salivary glands. These glands are present only in amniotes and are controlled by the parasympathetic system.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Salivary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "UMLS:C0036098" . [] oboInOwl:hasDbXref "MA:0000346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "salivary gland" . [] oboInOwl:hasDbXref "Wikipedia:Salivary_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001044 ; owl:annotatedTarget "glandulae salivariae" . [] oboInOwl:hasDbXref "GO:0007494", "Wikipedia:Midgut" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170119" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000290" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "in FMA this represents an embryonic region." . [] oboInOwl:source "ncithesaurus:Midgut" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "UMLS:C0231052" . [] oboInOwl:hasDbXref "Wikipedia:Midgut" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001045 ; owl:annotatedTarget "mesenteron" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget _:genid113787 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "The caudalmost subdivision of a digestive tract." . [] oboInOwl:source "MP:0008786" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "the caudal portion of the primitive digestive tube of the embryo" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000459" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "Reaxys:1722946" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "in FMA this class has no children. In MA it has a single child hindgut epithelium" . [] oboInOwl:source "ncithesaurus:Hindgut" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "UMLS:C0231053" . [] oboInOwl:hasDbXref "Wikipedia:Hindgut" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001046 ; owl:annotatedTarget "metenteron" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001048 ; owl:annotatedTarget obo:UBERON_0005423 . [] oboInOwl:hasDbXref "BTO:0001886", "FB:DJS", "FB:FBrf0089570", "http://flybase.org/reports/FBrf0178740.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001048 ; owl:annotatedTarget "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." . [] oboInOwl:source "ncithesaurus:Primordium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001048 ; owl:annotatedTarget "UMLS:C0678727" . [] oboInOwl:hasDbXref "FBbt:00005495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001048 ; owl:annotatedTarget "placode" . [] oboInOwl:hasDbXref "XAO:0003043" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001048 ; owl:annotatedTarget "primordia" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "rac-2-methylbutanedioic acid" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "Wikipedia:Neural_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010617" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:JOR" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000307" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/neural+tube" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000307" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . [] oboInOwl:source "GO:0021915" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium" . [] oboInOwl:source "ncithesaurus:Neural_Tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "UMLS:C0231024" . [] oboInOwl:hasDbXref "Wikipedia:Neural_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001049 ; owl:annotatedTarget "tubus neuralis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "(+-)-methylsuccinic acid" . [] oboInOwl:hasDbXref "Wikipedia:Hypopharynx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "Bottom part of the pharynx that connects to the esophagus." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000445" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/hypopharynx" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "The inferior portion of the pharynx, between the epiglottis and the larynx. [TFD][VHOG]" . _:genid113673 oboInOwl:source "ncithesaurus:Hypopharynx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "UMLS:C0020629" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000526 . [] oboInOwl:hasDbXref "FMA:54877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "laryngeal pharynx" . [] oboInOwl:hasDbXref "FMA:54877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "laryngopharynx" . [] oboInOwl:hasDbXref "BTO:0001740", "Wikipedia:Hypopharynx" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001051 ; owl:annotatedTarget "pars laryngea pharyngis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "(RS)-2-methylbutanedioic acid" . [] oboInOwl:order "4" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget _:genid113821 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget _:genid113824 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget _:genid113826 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000492", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget "The terminal portion of the intestinal tube, terminating with the anus." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001751" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:source "ncithesaurus:Rectum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget "UMLS:C0034896" . [] oboInOwl:hasDbXref "BTO:0001158" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001052 ; owl:annotatedTarget "intestinum rectum" . [] oboInOwl:hasDbXref "FMA:62955", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001062 ; owl:annotatedTarget "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." . [] oboInOwl:source "ncithesaurus:Anatomic_Structure_System_or_Substance" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001062 ; owl:annotatedTarget "UMLS:C1515976" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "(RS)-methylsuccinic acid" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget obo:UBERON_0007329 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget _:genid113839 . [] oboInOwl:hasDbXref "Wikipedia:Pancreatic_duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000256" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." . [] oboInOwl:hasDbXref "MESH:A03.734.667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "pancreatic duct" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "1,2-Propanedicarboxylic acid" . [] oboInOwl:source "ncithesaurus:Pancreatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "UMLS:C0030288" . [] oboInOwl:hasDbXref "FMA:16003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "chief pancreatic duct" . [] oboInOwl:hasDbXref "Wikipedia:Pancreatic_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "duct of Wirsung" . [] oboInOwl:hasDbXref "MA:0000126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "main pancreatic duct" . [] oboInOwl:hasDbXref "BTO:0002362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "canal of Wirsung" . [] oboInOwl:hasDbXref "BTO:0002362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001064 ; owl:annotatedTarget "hepaticopancreatic duct" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "2-methyl-butanedioic acid" . _:genid113710 oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Intervertebral_disk" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . [] oboInOwl:source "ncithesaurus:Intervertebral_Disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "UMLS:C0021815" . _:genid113712 oboInOwl:hasDbXref "FMA:10446", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "discus intervertebralis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011932 . [] oboInOwl:hasDbXref "Wikipedia:Spinal_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "spinal disc" . [] oboInOwl:hasDbXref "BTO:0003625" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "intervertebral fibrocartilage" . [] oboInOwl:hasDbXref "BTO:0003625" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001066 ; owl:annotatedTarget "spinal disk" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "2-methylbutanedioic acid" . _:genid113723 oboInOwl:hasDbXref "Wikipedia:Zygapophysial_joint" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001067 ; owl:annotatedTarget "A synovial joint between the prezygapophysis of one vertebra and the postzygapophysis of the vertebra directly above it. There are two facet joints in each spinal motion segment[WP]." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000925 . [] oboInOwl:source "ncithesaurus:Facet_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001067 ; owl:annotatedTarget "UMLS:C0224521" . _:genid113725 oboInOwl:hasDbXref "HP:0008482" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001067 ; owl:annotatedTarget "spinal facet joint" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0004872 . [] oboInOwl:hasDbXref "Wikipedia:Zygapophysial_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001067 ; owl:annotatedTarget "articulationes zygapophysiales" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "Methyl Succinic acid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget obo:UBERON_0001085 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget _:genid113879 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget "A zone of skin that is part of a back [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget "back zone of skin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget "skin, dorsal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001068 ; owl:annotatedTarget "zone of skin of back" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget obo:UBERON_0005396 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget _:genid113886 . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "Methylbutanedioic acid" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget _:genid113888 . _:genid113741 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget _:genid113891 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009145 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." . [] oboInOwl:source "ncithesaurus:External_Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget "UMLS:C0007275" . [] oboInOwl:hasDbXref "AAO:0010218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget "external carotid" . [] oboInOwl:hasDbXref "Wikipedia:External_carotid_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001070 ; owl:annotatedTarget "arteria carotis externa" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_89843 ; owl:annotatedTarget "Pyrotartaric acid" . [] oboInOwl:hasDbXref "Wikipedia:Superficial_part_of_transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001071 ; owl:annotatedTarget "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001071 ; owl:annotatedTarget "EMAPA:37117" . [] oboInOwl:source "ncithesaurus:Superficial_Cervical_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001071 ; owl:annotatedTarget "UMLS:C0226271" . [] oboInOwl:hasDbXref "Wikipedia:Superficial_part_of_transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001071 ; owl:annotatedTarget "superficial branch of transverse cervical artery" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "EC 6.4.1.1 (pyruvate carboxylase) inhibitors" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget obo:UBERON_0001585 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." . [] oboInOwl:source "FMA:10951" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001194" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Inferior_Vena_Cava" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "UMLS:C0042458" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "inferior caval vein" . [] oboInOwl:hasDbXref "Wikipedia:Venae_cavae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "inferior vena cava" . [] oboInOwl:hasDbXref "Wikipedia:Venae_cavae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "posterior vena cava" . [] oboInOwl:hasDbXref "VHOG:0001194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "caudal vena cava" . [] oboInOwl:hasDbXref "BTO:0002682", "Wikipedia:Inferior_vena_cava" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001072 ; owl:annotatedTarget "vena cava inferior" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "EC 6.4.1.1 inhibitor" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=46539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001073 ; owl:annotatedTarget "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001073 ; owl:annotatedTarget "EMAPA:37601" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "EC 6.4.1.1 inhibitors" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget obo:UBERON_0002323 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget _:genid113935 . _:genid113787 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget _:genid113938 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003104 . [] oboInOwl:hasDbXref "Wikipedia:Pericardium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "A potential space between the visceral and parietal layers of the pericardium." . [] oboInOwl:source "PMID:20959416" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget obo:NCBITaxon_7718 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate carboxylase (EC 6.4.1.1) inhibitor" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002220" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000556" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal)" . [] oboInOwl:source "ncithesaurus:Pericardial_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "UMLS:C0225972" . [] oboInOwl:hasDbXref "Wikipedia:Pericardial_cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "pericardial space" . [] oboInOwl:hasDbXref "Wikipedia:Pericardial_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001074 ; owl:annotatedTarget "cavitas pericardiaca" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate carboxylase (EC 6.4.1.1) inhibitors" . [] oboInOwl:hasDbXref "VSAO:0000183", "VSAO:curator", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "Ossified form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000126" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "Centra are represented by mineralized, calcified, or ossified portions that surround the notochord. The autocentrum, present in Danio and all other living teleosts, is formed by direct ossification outside the elastica externa of the notochord (Arratia, 1999).[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000697" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_2008" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "Cylindrical body of bone, round or oval in cross section, which functionally replaces the notochord.[AAO]" . [] oboInOwl:source "Wikipedia:Body_of_vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "The body is the largest part of a vertebra, and is more or less cylindrical in shape. Its upper and lower surfaces are flattened and rough, and give attachment to the intervertebral fibrocartilages, and each presents a rim around its circumference. In front, the body is convex from side to side and concave from above downward. Behind, it is flat from above downward and slightly concave from side to side. Its anterior surface presents a few small apertures, for the passage of nutrient vessels. On the posterior surface is a single large, irregular aperture, or occasionally more than one, for the exit of the basi-vertebral veins from the body of the vertebra. [WP,unvetted][Wikipedia:Body_of_vertebra]." . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "VSAO:0000183" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "The vertebral centrum may be cartilaginous, develop as cartilage but be replaced by bone or mineralized, or form directly through intramembranous ossification.[VSAO]" . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "VSAO definition states it surrounds notochord but not applicable to post-natal." . [] oboInOwl:source "ncithesaurus:Vertebral_Body" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "UMLS:C0223084" . [] oboInOwl:hasDbXref "FMA:11945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "body of vertebra" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "corpus vertebra" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate carboxylase inhibitor" . [] oboInOwl:hasDbXref "FMA:11945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "corpus vertebrae (vertebrale)" . [] oboInOwl:hasDbXref "FMA:11945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "vertebral body" . [] oboInOwl:hasDbXref "PMID:11746457" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "arcocentrum" . [] oboInOwl:hasDbXref "PMID:11746457", "ZFA:0000126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "autocentrum" . [] oboInOwl:hasDbXref "PMID:11746457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "holocentrum" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "centra" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_vertebra" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "corpus vertebrae" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "vertebral centra" . [] oboInOwl:hasDbXref "MA:0001457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001075 ; owl:annotatedTarget "vertebral centrum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate carboxylase inhibitors" . [] oboInOwl:hasDbXref "TAO:0001336", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "An extension of a neural arches dorsal to the neural canal[TAO,modified]." . _:genid113821 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000705" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_and_Maglia_2008" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "Elaboration of the mid-dorsal keel into a posterior or posterolateral process.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000059 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001336" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "Neural spines are extensions of neural arches dorsal to the neural canal in the median skeletogenous septum. Neural spines are typically unpaired median structures but can be paired in some instances, e.g., in the abdominal region of basal teleosts such as Leptolepis, Elops, Megalops, and Hiodon).[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000739" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_2002" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "Small, posteriorly directed process at the posterior margin of each neural arch lamina; it is not a neural spine.[AAO]" . _:genid113824 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000705" ; oboInOwl:ontology "AAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "relationship loss: part_of mid-dorsal keel (AAO:0000735)[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012361 . [] oboInOwl:hasDbXref "FMA:11948" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "spinous process of vertebra" . _:genid113826 oboInOwl:hasDbXref "MA:0001455" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "vertebra spinous process" ; owl:onProperty obo:BSPO_0001108 ; owl:someValuesFrom obo:UBERON_0000059 . [] oboInOwl:hasDbXref "ZFA:0001336" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "neural spines" . [] oboInOwl:hasDbXref "FMA:11948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001076 ; owl:annotatedTarget "spine of verterba" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001077 ; owl:annotatedTarget "The transverse or costal processes of a vertebra, two in number, project one at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes. They serve for the attachment of muscles and ligaments. [WP,unvetted]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor" . [] oboInOwl:source "AAO:0000698" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001077 ; owl:annotatedTarget "Projections on each side of the vertebra from the point where the neural arch lamina joins the pedicel for the articulation with the head of a single-headed rib or the upper head of a double-headed rib. Also called diapophyses. They provide surfaces for the attachment of muscles. In anurans, the term transverse process is used in reference to the processes associated with the presacral and postsacral vertebrae." . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0004604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "The two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae." . [] oboInOwl:source "ncithesaurus:Pedicle_of_Vertebral_Arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "UMLS:C0223080" . [] oboInOwl:hasDbXref "FMA:11950" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "pedicle of vertebral arch" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "pediculus arcus vertebrae" . [] oboInOwl:hasDbXref "FMA:11950" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "vertebral pedicle" . [] oboInOwl:hasDbXref "Wikipedia:Pedicle_of_vertebral_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "pediculus arcus vertebrae" . [] oboInOwl:hasDbXref "Wikipedia:Pedicle_of_vertebral_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001078 ; owl:annotatedTarget "radix arcus vertebrae" . _:genid113839 oboInOwl:hasDbXref "AAO:Pugener_and_Maglia_2008" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "Paired processes at the cephalic end of the neural arch. The articular facets of the prezygapophyses face dorsomedially and articulate with the lateroventrally facing facets of the postzygapophyses of the preceding vertebra." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003924 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001325" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "Paired, anteromedially directed processes from the neural arches, ligamentously joined to the postzygapophyses of the preceding vertebra.[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "EMAPA:37802" . [] oboInOwl:hasDbXref "FMA:11953", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "processus articularis superior vertebrae" . [] oboInOwl:hasDbXref "FMA:11953" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "superior articular process of vertebra" . [] oboInOwl:hasDbXref "FMA:11953", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "zygapophysis superior" . [] oboInOwl:hasDbXref "ZFA:0001325" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "neural prezygapophysis" . [] oboInOwl:hasDbXref "ZFA:0001325" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "neural prezygopophyses" . [] oboInOwl:hasDbXref "TAO:0001325" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001079 ; owl:annotatedTarget "neural prezygapophyses" . [] oboInOwl:hasDbXref "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "Paired processes at the caudal end of the neural arch. The articular facets of the postzygapophyses face lateroventrally and articulate with the dorsomedially facing facets of the prezygapophyses of the succeeding vertebra." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000681" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "Paired, dorsomedially directed processes on the posterior ends of the centra, ligamentously joined to the neural prezygapophyses of the immediately posterior vertebra.[TAO]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvic carboxylase inhibitor" . [] oboInOwl:hasDbXref "FMA:11954" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "inferior articular process of vertebra" . [] oboInOwl:hasDbXref "ZFA:0000681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "neural postzygopophysis" . [] oboInOwl:hasDbXref "FMA:11954", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "processus articularis inferior vertebrae" . [] oboInOwl:hasDbXref "FMA:11954", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "zygapophysis inferior" . [] oboInOwl:hasDbXref "ZFA:0000681" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "neural postzygapophysis" . [] oboInOwl:hasDbXref "TAO:0000681" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "neural postzygapophyses" . [] oboInOwl:hasDbXref "TAO:0000681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "neural postzygopophyses" . [] oboInOwl:hasDbXref "AAO:0000702" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001080 ; owl:annotatedTarget "processus obliquus posterior" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90318 ; owl:annotatedTarget "pyruvic carboxylase inhibitors" . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget _:genid114016 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "Endocardium that is part of the cardiac ventricle." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "cardiac ventricle endocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "endocardium of cardiac ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "endocardium of heart ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "endocardium of lower chamber of heart" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90710 ; owl:annotatedTarget "receptor modulators" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "endocardium of ventricle of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "heart ventricle endocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "lower chamber of heart endocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "ventricle of heart endocardium" . [] oboInOwl:hasDbXref "VHOG:0000607" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001081 ; owl:annotatedTarget "ventricle endocardial tissue" . _:genid113879 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082, obo:UBERON_0011270 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001082 ; owl:annotatedTarget "An epicardial layer that lines a cardiac ventricle." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005058" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001082 ; owl:annotatedTarget "The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001082 ; owl:annotatedTarget "cardiac ventricle epicardium" . ( ) . _:genid113888 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001530, obo:UBERON_0002082 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001083 ; owl:annotatedTarget _:genid114042 . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_90799 ; owl:annotatedTarget "a dipeptide" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001083 ; owl:annotatedTarget "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." . _:genid113891 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005061" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001083 ; owl:annotatedTarget "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO]" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001530 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000604" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001083 ; owl:annotatedTarget "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000604" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001083 ; owl:annotatedTarget "ventricle cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "A zone of skin that is part of a head [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Head_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "UMLS:C0205029" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "adult head zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "head zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "zone of skin of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001084 ; owl:annotatedTarget "zone of skin of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "A zone of skin that is part of a trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "EMAPA:37278" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_91007 ; owl:annotatedTarget "an aromatic carboxylate" . [] oboInOwl:source "ncithesaurus:Skin_of_the_Trunk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "UMLS:C0205031" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "torso zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "trunk zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "zone of skin of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001085 ; owl:annotatedTarget "zone of skin of trunk" . [] oboInOwl:hasDbXref "FMA:12273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001087 ; owl:annotatedTarget "Transudate contained in the pleural cavity." . [] oboInOwl:hasDbXref "Wikipedia:Urine", "https://github.com/geneontology/go-ontology/issues/11025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001088 ; owl:annotatedTarget "Excretion that is the output of a kidney." . [] oboInOwl:source "ncithesaurus:Urine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001088 ; owl:annotatedTarget "UMLS:C0042036" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_91315 ; owl:annotatedTarget "2-methylbutanedioic acid" . [] oboInOwl:hasDbXref "FMA:12275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001089 ; owl:annotatedTarget "Secretion produced by a sweat gland." . [] oboInOwl:source "ncithesaurus:Sweat" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001089 ; owl:annotatedTarget "UMLS:C0038984" . [] oboInOwl:hasDbXref "BTO:0001254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001089 ; owl:annotatedTarget "skin exudate" . (obo:UBERON_0007779 [ a owl:Restriction ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:CL_0000214 ] ) . _:genid113938 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:CHEBI_16336, obo:UBERON_0003887 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001090 ; owl:annotatedTarget obo:UBERON_0007794 . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK274/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001090 ; owl:annotatedTarget "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005154" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001090 ; owl:annotatedTarget "Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO]" . [] oboInOwl:source "ncithesaurus:Synovial_Fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001090 ; owl:annotatedTarget "UMLS:C0039097" . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK274/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001090 ; owl:annotatedTarget "joint fluid" . [] oboInOwl:source "XAO-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget _:genid114101 . [] oboInOwl:source "ZFA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget _:genid114103 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget _:genid114105 . [] oboInOwl:hasDbXref "Wikipedia:Tooth_(animal)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget "Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget obo:NCBITaxon_189497 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001733" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:19266065 Koussoulakou DS, Margaritis LH, Koussoulakos SL, A curriculum vitae of teeth: evolution, generation, regeneration. International Journal of Biological Sciences (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget "The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes.[well established][VHOG]" . [] oboInOwl:source "PMID:10210685" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget "absent in living platypus, present in toothed Miocene platypus Obduron dicksoni" . [] oboInOwl:source "ncithesaurus:Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget "UMLS:C0040426" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001091 ; owl:annotatedTarget "dental element" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "The first vertebral bone in the vertebral column." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000709" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001167" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "Vertebra that is posteriorly adjacent to the neurocranium.[TAO]" . [] oboInOwl:source "ncithesaurus:C1_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "UMLS:C0004170" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_91316 ; owl:annotatedTarget "Reaxys:1722948" . [] oboInOwl:hasDbXref "FMA:12519", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "atlas [C I]" . [] oboInOwl:hasDbXref "MP:0011576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "cervical atlas" . [] oboInOwl:hasDbXref "MA:0001421" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "cervical vertebra 1" . [] oboInOwl:hasDbXref "TAO:0001167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001092 ; owl:annotatedTarget "vertebra 1" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget _:genid114122 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "The second vertebral bone in the vertebral column." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001168" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "Vertebra that is posteriorly adjacent to vertebra 1.[TAO]" . [] oboInOwl:source "ncithesaurus:C2_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "UMLS:C0004457" . [] oboInOwl:hasDbXref "FMA:12520", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "axis [C II]" . [] oboInOwl:hasDbXref "MP:0004608" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "cervical axis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_91316 ; owl:annotatedTarget "(2S)-2-methylbutanedioic acid" . [] oboInOwl:hasDbXref "ZFA:0001168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "vertebra 2" . [] oboInOwl:hasDbXref "MA:0001422" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "cervical vertebra 2" . [] oboInOwl:hasDbXref "MA:0001422" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001093 ; owl:annotatedTarget "axis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001094 ; owl:annotatedTarget "A vertebra bone that is part of the sacral region of the vertebral column." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000552" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001094 ; owl:annotatedTarget "Enlarged vertebra with transverse processes (diapophyses), and ocassionally ribs, that are modified and elaborated for support of the pelvic girdle.[AAO]" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_91316 ; owl:annotatedTarget "(S)-2-methylbutanedioic acid" . [] oboInOwl:source "ncithesaurus:Sacral_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001094 ; owl:annotatedTarget "UMLS:C1261045" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000326" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "we deliberately merge the MA classes as we believe them equivalent" . [] oboInOwl:hasDbXref "FMA:12527" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "caudal vertebra" . [] oboInOwl:source "ncithesaurus:Coccygeal_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "UMLS:C0223616" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "caudal vertebrae" . [] oboInOwl:hasDbXref "FMA:12527" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "coccygeal vertebra" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "fused tail vertebra" . [] oboInOwl:hasDbXref "MA:0001420" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "coccygea" . [] oboInOwl:hasDbXref "MA:0000310" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001095 ; owl:annotatedTarget "tail vertebra" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_91317 ; owl:annotatedTarget "CAS:3641-51-8" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "An anatomical wall that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "anatomical wall of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "anatomical wall of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "anatomical wall of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "esophagus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "gullet anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "gullet wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "oesophagus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "oesophagus wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "wall of gullet" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_91317 ; owl:annotatedTarget "Reaxys:1722947" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001096 ; owl:annotatedTarget "wall of oesophagus" . [] oboInOwl:hasDbXref "Wikipedia:Incisor_tooth", "https://github.com/obophenotype/uberon/issues/221" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001098 ; owl:annotatedTarget "Incisors are the first kind of tooth in heterodont mammals. They are located in the premaxilla above and mandible below. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Incisor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001098 ; owl:annotatedTarget "UMLS:C0021156" . [] oboInOwl:hasDbXref "MA:0000349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001098 ; owl:annotatedTarget "incisor" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget obo:UBERON_0001495 . _:genid114016 oboInOwl:notes "third to fifth ribs near their costal cartilages" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget _:genid114175 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004784 . [] oboInOwl:notes "medial border and superior surface of the coracoid process of the scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget _:genid114177 . [] oboInOwl:hasDbXref "Wikipedia:Pectoralis_minor_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget "The Pectoralis minor is a thin, triangular muscle, situated at the upper part of the chest, beneath the Pectoralis major. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Pectoralis_Minor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget "UMLS:C0224347" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_91317 ; owl:annotatedTarget "(2R)-2-methylbutanedioic acid" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget "supracoracoideus" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget "supracoracoideus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Pectoralis_minor_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001100 ; owl:annotatedTarget "musculus pectoralis minor" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget _:genid114188 . [] oboInOwl:hasDbXref "MP:0002279" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." . [] oboInOwl:source "GO:0060539" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs[GO]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_91317 ; owl:annotatedTarget "(R)-2-methylbutanedioic acid" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000713" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471384618 Colbert EH, Evolution of the vertebrates: a history of the backboned animals through time (2001) p.278", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "The mammals are characterized by a diaphragm, which separates the thoracic portion of the body cavity from the abdominal region and assists in drawing air into the lungs and forcing it out. Modern reptiles lack a muscular diaphragm and it is reasonable to suppose that the diaphragm developed as a new device that made possible a large degree of oxygen intake for active animals. The change may have taken place during the transition from reptile to mammal (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Diaphragm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "UMLS:C0011980" . [] oboInOwl:hasDbXref "BTO:0000341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "diaphragm muscle" . [] oboInOwl:hasDbXref "BTO:0000341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "midriff" . [] oboInOwl:hasDbXref "BTO:0000341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001103 ; owl:annotatedTarget "phren" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget obo:UBERON_0002495 . [] oboInOwl:source "FMA", "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget _:genid114198 . [] oboInOwl:editor "mah" ; oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget _:genid114201 . [] oboInOwl:notes "from secondary cartilage of fusion" ; oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget _:genid114203 . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_91317 ; owl:annotatedTarget "d-Methylsuccinic acid" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "A paired dermal or endochondral bone that is part of the pectoral girdle. The clavicle may be in contact with the interclavicle or coracoid and forms an attachment site for pectoral musculature. [PHENOSCAPE:ad]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000761" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "Slender, paired bones of intramembranous origin that invest the anterior margins of the procoracoids.[AAO]" . _:genid114042 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000761" ; oboInOwl:ontology "AAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "relationship loss: part_of zonal element (AAO:0000936)[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004784 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000849" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.330-333 and Figure 9.18", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "In early tetrapods, the connecting skull bone, the posttemporal, and adjoining shoulder bones, supracleithrum and postcleithrum (=anocleithrum), are absent, leaving a dermal shoulder girdle composed of the remaining ventral elements: the paired cleithrum and clavicle, and an unpaired midventral interclavicle that joins both halves of the girdle across the midline. (...) Several dermal elements of the shoulder persist in early synapsids. The clavicle and interclavicle are present in therapsids and monotremes, but in marsupials and placentals, the interclavicle is absent, the clavicle often is reduced in size, and the scapula becomes the predominant shoulder element.[well established][VHOG]" . [] oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "FMA and MA differ in whether they consider this part of the shoulder" . [] oboInOwl:source "ncithesaurus:Clavicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "UMLS:C0008913" . [] oboInOwl:hasDbXref "VSAO:0005031" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "clavicle" . [] oboInOwl:hasDbXref "VSAO:0005031" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001105 ; owl:annotatedTarget "clavicula" . [] oboInOwl:hasDbXref "CARO:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000000 ; owl:annotatedTarget "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget _:genid114223 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget _:genid114225 . [] oboInOwl:hasDbXref "CARO:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000003 ; owl:annotatedTarget "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." . [] oboInOwl:notes "ribs 1-11" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget _:genid114227 . [] oboInOwl:notes "ribs 2-12" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget _:genid114229 . [] oboInOwl:hasDbXref "MESH:A02.633.567.900.500", "MGI:csmith", "MP:0002280" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget "The respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000903" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0262112789 Kent RD, The MIT Encyclopedia of Communication Disorders (20039 p.56", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget "Inspiration by active expansion of the thorax evolved later, in the ancestor of reptiles, birds, and mammals. This was powered originally by the intercostal muscles (as in lizards or crocodilians) and later (in mammals only) by a muscular diaphragm.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Intercostal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget "UMLS:C0021724" . [] oboInOwl:hasDbXref "FMA:13354", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001111 ; owl:annotatedTarget "musculus intercostalis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114235 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114237 . [] oboInOwl:notes "spinous processes of thoracic T7-T12 thoracolumbar fascia iliac crest and inferior 3 or 4 ribs inferior angle of scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114240 . [] oboInOwl:notes "floor of intertubercular groove of the humerus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114242 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114244 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget _:genid114246 . [] oboInOwl:hasDbXref "Wikipedia:Latissimus_dorsi_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget "The latissimus dorsi is the larger, flat, dorso-lateral muscle on the trunk, posterior to the arm, and partly covered by the trapezius on its median dorsal region. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Musculus_Latissimus_Dorsi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget "UMLS:C0224362" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget "latissimi dorsi" . [] oboInOwl:hasDbXref "Wikipedia:Latissimus_dorsi_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001112 ; owl:annotatedTarget "musculus latissimus dorsi" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001113 ; owl:annotatedTarget obo:UBERON_0009912 . [] oboInOwl:hasDbXref "Wikipedia:Liver#Lobes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001113 ; owl:annotatedTarget "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." . [] oboInOwl:source "ncithesaurus:Liver_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001113 ; owl:annotatedTarget "UMLS:C0447541" . [] oboInOwl:hasDbXref "Wikipedia:Right_lobe_of_liver" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005173" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO]" . [] oboInOwl:source "ncithesaurus:Right_Lobe_of_the_Liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "UMLS:C0227481" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "lobus hepaticus dexter" . [] oboInOwl:hasDbXref "ZFA:0005173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "right liver lobe" . [] oboInOwl:hasDbXref "TAO:0005173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "2nd lobe" . [] oboInOwl:hasDbXref "ZFA:0005173" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "gall bladder lobe" . [] oboInOwl:hasDbXref "Wikipedia:Right_lobe_of_liver" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "lobus hepatis dexter" . [] oboInOwl:hasDbXref "EMAPA:18311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "right hepatic lobe" . [] oboInOwl:hasDbXref "TAO:0005173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001114 ; owl:annotatedTarget "second lobe" . [] oboInOwl:hasDbXref "Wikipedia:Left_lobe_of_liver" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005172" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "Portion of the liver which develops on the fish's left side.[TAO]" . [] oboInOwl:source "ncithesaurus:Left_Lobe_of_the_Liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "UMLS:C0227486" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "lobus hepaticus sinister" . [] oboInOwl:hasDbXref "EMAPA:18307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "left hepatic lobe" . [] oboInOwl:hasDbXref "Wikipedia:Left_lobe_of_liver" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001115 ; owl:annotatedTarget "lobus hepatis sinister" . _:genid114101 oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget _:genid114276 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000930 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget "A lobe of tissue that is part of a thyroid gland." . _:genid114103 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000732" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://www.thyroidmanager.org/Chapter1/chapter01.htm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005176 . [] oboInOwl:source "ncithesaurus:Thyroid_Gland_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget "UMLS:C0447647" . _:genid114105 oboInOwl:hasDbXref "FMA:13367", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget "lobus glandulae thyroideae" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0008281 . [] oboInOwl:hasDbXref "Wikipedia:Lobes_of_thyroid_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001118 ; owl:annotatedTarget "lobuli glandulae thyroideae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001119 ; owl:annotatedTarget "A lobe of thyroid gland that is in the right side of a thyroid gland." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000733" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://www.thyroidmanager.org/Chapter1/chapter01.htm" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001119 ; owl:annotatedTarget "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Right_Thyroid_Gland_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001119 ; owl:annotatedTarget "UMLS:C0229581" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001120 ; owl:annotatedTarget "A lobe of thyroid gland that is in the left side of a thyroid gland." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000734" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://www.thyroidmanager.org/Chapter1/chapter01.htm" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001120 ; owl:annotatedTarget "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000005 ; owl:annotatedTarget "Any fibroblast that is deriived from the neural crest." . [] oboInOwl:source "ncithesaurus:Left_Thyroid_Gland_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001120 ; owl:annotatedTarget "UMLS:C0229582" . [] oboInOwl:notes "long thoracic nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget _:genid114297 . _:genid114122 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget _:genid114299 ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0001092 . [] oboInOwl:notes "fleshy slips from the outer surface of upper 8 or 9 ribs" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget _:genid114301 . [] oboInOwl:notes "costal aspect of medial margin of the scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget _:genid114303 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget _:genid114305 . [] oboInOwl:hasDbXref "Wikipedia:Serratus_anterior_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget "The serratus ventralis is a muscle that originates on the surface of the upper eight or nine ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Serratus_Ventralis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget "UMLS:C1710059" . [] oboInOwl:hasDbXref "VHOG:0000679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget "serratus anterior" . [] oboInOwl:hasDbXref "Wikipedia:Serratus_anterior_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget "musculus serratus anterior" . [] oboInOwl:hasDbXref "Wikipedia:Serratus_anterior_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001125 ; owl:annotatedTarget "serratus lateralis" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget _:genid114316 . [] oboInOwl:hasDbXref "VSAO:0000185", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000185" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "Anatomical cluster that consists of all the vertebra in the body.[VSAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001142" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/vertebral+column" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001142" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.53", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:13478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "spine" . [] oboInOwl:source "ncithesaurus:Vertebral_Column" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "UMLS:C0037949" . [] oboInOwl:source "ncithesaurus:Spinal_Cord_Column" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "UMLS:C1519455" . [] oboInOwl:hasDbXref "FMA:13478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "backbone" . [] oboInOwl:hasDbXref "AAO:0000699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "vertebral column skeleton" . [] oboInOwl:hasDbXref "BTO:0000818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "columna vertebralis" . [] oboInOwl:hasDbXref "BTO:0000818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "dorsal spine" . [] oboInOwl:hasDbXref "MESH:A02.835.232.834" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001130 ; owl:annotatedTarget "spinal column" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_foramen", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001131 ; owl:annotatedTarget "A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000729" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001131 ; owl:annotatedTarget "Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001131 ; owl:annotatedTarget "EMAPA:37803" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_foramen" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001131 ; owl:annotatedTarget "foramen vertebrale" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget _:genid114345 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000678", "Wikipedia:Parathyroid_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001188" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/parathyroid+gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "Any one of several small structures, usually four, attached to the dorsal surfaces of the lateral lobes of the thyroid gland. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010545" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "Either of the two pairs of small, spherical, encapsulated glands which develop from ventral growths of the third and fourth pharyngeal pouches and are closely associated with the external jugular veins. Calcitonin and parathyroid hormone are secreted by these glands.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001188" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "The evolution of the tetrapods, and the shift from an aquatic to a terrestrial environment, was believed to have required new controls for regulating calcium homeostasis, and thus the evolution of parathyroid glands (...) both the tetrapod parathyroid and the gills of fish contribute to the regulation of extracellular calcium levels. It is therefore reasonable to suggest that the parathyroid gland evolved as a result of the transformation of the gills into the parathyroid glands of tetrapods and the transition from an aquatic to a terrestrial environment. This interpretation would also explain the positioning of the parathyroid gland within the pharynx in the tetrapod body. Were the parathyroid gland to have emerged de novo with the evolution of the tetrapods it could, as an endocrine organ, have been placed anywhere in the body and still exert its effect.[well established][VHOG]" . [] oboInOwl:source "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "table 13.1 of Kardong is used to create the taxon-specific developmental relationships here, although some omissions are made for simplicity." . [] oboInOwl:source "ncithesaurus:Parathyroid_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "UMLS:C0030518" . [] oboInOwl:hasDbXref "XAO:0000167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001132 ; owl:annotatedTarget "epithelial body" . _:genid114175 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002228, obo:UBERON_0007100 . _:genid114177 oboInOwl:hasDbXref "ZFA:0005280" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0007174 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "cardiac muscle muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "cardiac muscle textus muscularis" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000007 ; owl:annotatedTarget "A cell found in the embryo before the formation of all the gem layers is complete." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "heart muscle muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "heart muscle textus muscularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "heart myocardium muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "heart myocardium textus muscularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle of heart muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle of heart textus muscularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle tissue of cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle tissue of heart muscle" . _:genid114188 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle tissue of heart myocardium" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010084 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle tissue of muscle of heart" . [] oboInOwl:hasDbXref "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000008 ; owl:annotatedTarget "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "muscle tissue of myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "myocardium muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "myocardium textus muscularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "textus muscularis of cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "textus muscularis of heart muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "textus muscularis of heart myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "textus muscularis of muscle of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "textus muscularis of myocardium" . _:genid114198 oboInOwl:hasDbXref "BILA:0000134" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001133 ; owl:annotatedTarget "cardiac musculature" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "Beilstein:3904386" . [] oboInOwl:hasDbXref "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000011 ; owl:annotatedTarget "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." . _:genid114201 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002473 ; owl:someValuesFrom obo:CL_0008002, obo:UBERON_0010905 . _:genid114203 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0010843, obo:UBERON_0014892 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "Muscle tissue that consists primarily of skeletal muscle fibers." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005277" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" . [] oboInOwl:external_class "FMA:14069" ; oboInOwl:ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000319" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:10368962 Oota S, Saitou N, Phylogenetic relationship of muscle tissues deduced from superimposition of gene trees. Mol Biol Evol (1999)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Skeletal_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "UMLS:C0242692" . [] oboInOwl:hasDbXref "BTO:0001103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "skeletal muscle system" . [] oboInOwl:hasDbXref "BTO:0001103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001134 ; owl:annotatedTarget "somatic muscle" . [] oboInOwl:hasDbXref "GO:0006939", "Wikipedia:Smooth_muscle_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005274" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010244" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:CAM" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001246" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "UMLS:C1267092" . _:genid114223 oboInOwl:hasDbXref "FMA:14070", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "textus muscularis nonstriatus" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003727 . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "visceral muscle" . _:genid114225 oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "visceral muscle tissue" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010970 . [] oboInOwl:hasDbXref "Wikipedia:Smooth_muscle_tissue" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001135 ; owl:annotatedTarget "textus muscularis levis; textus muscularis nonstriatus" . _:genid114227 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000487 _:genid114229 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 ] ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002228 . _:genid114229 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000042, obo:UBERON_0002228 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001136 ; owl:annotatedTarget _:genid114416 . [] oboInOwl:hasDbXref "FMA:14074", "Wikipedia:Mesothelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001136 ; owl:annotatedTarget "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." . _:genid114235 oboInOwl:source "ncithesaurus:Mesothelium" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001136 ; owl:annotatedTarget "UMLS:C0086610" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008713 . [] oboInOwl:hasDbXref "BSPO:0000063", "UBERONREF:0000006", "Wikipedia:Dorsum_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001137 ; owl:annotatedTarget "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." . _:genid114237 oboInOwl:source "ncithesaurus:Back" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001137 ; owl:annotatedTarget "UMLS:C0004600" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010982 . [] oboInOwl:hasDbXref "FMA:14181" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001137 ; owl:annotatedTarget "back" . [] oboInOwl:hasDbXref "FMA:14181" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001137 ; owl:annotatedTarget "back of body proper" . _:genid114240 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005617 _:genid114242 ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0007175 . _:genid114242 a owl:Restriction ; owl:onProperty obo:RO_0002179, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000976, obo:UBERON_0002108 . _:genid114244 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001476, obo:UBERON_0005806 . _:genid114246 oboInOwl:source "Wikipedia:Vitelline_vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001138 ; owl:annotatedTarget _:genid114430 ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0002380 . [] oboInOwl:hasDbXref "Wikipedia:Superior_mesenteric_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001138 ; owl:annotatedTarget "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Superior_Mesenteric_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001138 ; owl:annotatedTarget "UMLS:C0226742" . [] oboInOwl:hasDbXref "BTO:0002783" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001138 ; owl:annotatedTarget "upper mesenteric vein" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget obo:CL_0000034 . [] oboInOwl:hasDbXref "Wikipedia:Superior_mesenteric_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001138 ; owl:annotatedTarget "vena mesenterica superior" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget obo:UBERON_0005610 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget _:genid114437 . [] oboInOwl:hasDbXref "MURDOCH:403", "Wikipedia:Common_iliac_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget "A vein that drains the pelvis and lower limbs into the inferior vena cava." . [] oboInOwl:source "Wikipedia:Common_iliac_vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget "In human anatomy, the common iliac veins are formed by the external iliac veins and internal iliac veins and together, in the abdomen at the level of the fifth lumbar vertebrae, form the inferior vena cava. They drain blood from the pelvis and lower limbs. Both common iliac veins are accompanied along their course by common iliac arteries." . [] oboInOwl:source "ncithesaurus:Common_Iliac_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget "UMLS:C0226758" . [] oboInOwl:hasDbXref "Wikipedia:Common_iliac_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001139 ; owl:annotatedTarget "vena iliaca communis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget obo:CL_0000039 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0011323" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." . [] oboInOwl:source "Wikipedia:Renal_vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "in EHDAA2, the renal vein is part of the kidney" . [] oboInOwl:source "ncithesaurus:Renal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "UMLS:C0035092" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "kidney vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "vein of kidney" . [] oboInOwl:hasDbXref "Wikipedia:Renal_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001140 ; owl:annotatedTarget "venae renales" . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2012.05.016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000014 ; owl:annotatedTarget "A stem cell that is the precursor of gametes." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001141 ; owl:annotatedTarget "A renal vein that drains the right kidney." . [] oboInOwl:source "ncithesaurus:Right_Renal_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001141 ; owl:annotatedTarget "A vein that drains blood from the right kidney into the inferior vena cava[ncithesaurus]." . _:genid114276 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001141 ; owl:annotatedTarget "EMAPA:37381" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002046 . [] oboInOwl:source "ncithesaurus:Right_Renal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001141 ; owl:annotatedTarget "UMLS:C0508000" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001142 ; owl:annotatedTarget "A renal vein that drains the left kidney." . [] oboInOwl:source "ncithesaurus:Left_Renal_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001142 ; owl:annotatedTarget "A vein that drains blood from the left kidney into the inferior vena cava[ncithesaurus]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001142 ; owl:annotatedTarget "EMAPA:37166" . [] oboInOwl:source "ncithesaurus:Left_Renal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001142 ; owl:annotatedTarget "UMLS:C0508001" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget obo:CL_0000586 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget _:genid114477 . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_vein", "ZFA:0000670", "https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "Vein that carries blood away from the liver[ZFA]." . [] oboInOwl:source "ncithesaurus:Hepatic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "UMLS:C0019155" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "liver vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "vein of liver" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "vena hepatica" . _:genid114297 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "hepatic veins" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003726 . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001143 ; owl:annotatedTarget "venae hepaticae" . _:genid114299 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001638 _:genid114301 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010986 . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "CAS:156-80-9" . [] oboInOwl:hasDbXref "PMID:29462262", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000015 ; owl:annotatedTarget "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." . _:genid114301 a owl:Restriction ; owl:onProperty obo:RO_0002179, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000473, obo:UBERON_0002228 . _:genid114303 a owl:Restriction ; owl:onProperty obo:BSPO_0000126, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000468, obo:UBERON_0006849 . _:genid114305 a owl:Restriction ; owl:onProperty obo:RO_0002170, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001330, obo:UBERON_0002380 . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein", "http://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/?func=detail&aid=3220553&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "A vein that carries deoxygenated blood from a single male gonad. It is the male equivalent of the ovarian vein, and is the venous counterpart of the testicular artery. It is a paired vein, with one supplying each testis." . [] oboInOwl:source "ncithesaurus:Spermatic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "UMLS:C0226718" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "male gonadal vein" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "spermatic vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "testicle vein" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "testicular venous tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "vein of testicle" . [] oboInOwl:hasDbXref "BTO:0002678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "vena tesicularis" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "vena testicularis dextra" . _:genid114316 oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "vena testicularis sinistra" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011138 . [] oboInOwl:hasDbXref "Wikipedia:Testicular_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001144 ; owl:annotatedTarget "venae spermaticae" . [] oboInOwl:hasDbXref "Wikipedia:Ovarian_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." . [] oboInOwl:source "ncithesaurus:Ovarian_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "UMLS:C0226720" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "female reproductive system gonad vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "female reproductive system gonada vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "gonad of female reproductive system vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "gonada of female reproductive system vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "ovary vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vein of female reproductive system gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vein of female reproductive system gonada" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vein of gonad of female reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vein of gonada of female reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vein of ovary" . [] oboInOwl:hasDbXref "Wikipedia:Ovarian_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vena ovarica dextra" . [] oboInOwl:hasDbXref "Wikipedia:Ovarian_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001145 ; owl:annotatedTarget "vena ovarica sinistra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/mouse-anatomy-ontology/issues/110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001146 ; owl:annotatedTarget "A vein that drains the adrenal gland." . [] oboInOwl:source "ncithesaurus:Suprarenal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001146 ; owl:annotatedTarget "UMLS:C0226717" . [] oboInOwl:hasDbXref "MA:0002081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001146 ; owl:annotatedTarget "adrenal vein" . _:genid114345 a owl:Restriction ; owl:onProperty obo:RO_0002216, obo:RO_0002380 ; owl:someValuesFrom obo:GO_0055074, obo:UBERON_0001814 . [] oboInOwl:hasDbXref "Wikipedia:Median_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001148 ; owl:annotatedTarget "A nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery. It originates from the brachial plexus with roots from C5, C6, C7, C8 & T1." . [] oboInOwl:source "ncithesaurus:Median_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001148 ; owl:annotatedTarget "UMLS:C0025058" . [] oboInOwl:hasDbXref "Wikipedia:Median_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001148 ; owl:annotatedTarget "nervus medianus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget obo:UBERON_0003703 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget _:genid114543 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget _:genid114545 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000017 ; owl:annotatedTarget obo:CL_0000015 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0009493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005166" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget "Duct that connects the gall bladder and the common bile duct.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000213" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget "The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:source "ncithesaurus:Cystic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget "UMLS:C0010672" . [] oboInOwl:hasDbXref "Wikipedia:Cystic_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001152 ; owl:annotatedTarget "ductus cysticus" . [] oboInOwl:order "3" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget _:genid114555 . [] oboInOwl:hasDbXref "Wikipedia:Colon_(anatomy)", "ZFIN:curator", "http://orcid.org/0000-0002-2825-0621", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-1572-1316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "Some references do not consider the caecum to be part of the colon." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013090" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000017 ; owl:annotatedTarget "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010400" ; oboInOwl:ontology "AAO" ; oboInOwl:source "UBERON:0001155" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "The last portion of the digestive system, it extracts water and salt from solid wastes before they are eliminated from the body.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000706" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "The posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates. Wallace et al, 2005.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000648" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Colon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001155 ; owl:annotatedTarget "UMLS:C0009368" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001158 ; owl:annotatedTarget obo:UBERON_0000168 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001158 ; owl:annotatedTarget _:genid114566 . [] oboInOwl:hasDbXref "BTO:0000641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001158 ; owl:annotatedTarget "The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon." . [] oboInOwl:source "ncithesaurus:Descending_Colon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001158 ; owl:annotatedTarget "UMLS:C0227389" . [] oboInOwl:hasDbXref "Wikipedia:Descending_colon" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001158 ; owl:annotatedTarget "colon descendens" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget obo:UBERON_0000168 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget _:genid114573 . [] oboInOwl:hasDbXref "Wikipedia:Sigmoid_colon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." . [] oboInOwl:source "ncithesaurus:Sigmoid_Colon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget "UMLS:C0227391" . [] oboInOwl:source "ncithesaurus:Sigmoid_Flexure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget "UMLS:C0682612" . [] oboInOwl:hasDbXref "Wikipedia:Sigmoid_colon" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001159 ; owl:annotatedTarget "colon sigmoideum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget obo:UBERON_0009870 . [] oboInOwl:hasDbXref "GO:0014845", "Wikipedia:Body_of_stomach" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." . [] oboInOwl:source "ncithesaurus:Body_of_Stomach" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget "UMLS:C0227230" . [] oboInOwl:hasDbXref "BTO:0000505", "Wikipedia:Body_of_stomach" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget "corpus gastricum" . [] oboInOwl:hasDbXref "BTO:0000505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget "corpus ventriculare" . [] oboInOwl:hasDbXref "BTO:0000505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001161 ; owl:annotatedTarget "corpus ventriculi" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget obo:UBERON_0009870 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget _:genid114586 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "Gmelin:141932" . [] oboInOwl:source "ncithesaurus:Antrum_Pylori" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "UMLS:C0034193" . [] oboInOwl:hasDbXref "BTO:0001732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "antrum of Willis" . [] oboInOwl:hasDbXref "BTO:0001732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "antrum pylori" . [] oboInOwl:hasDbXref "BTO:0001732", "Wikipedia:Pyloric_antrum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "antrum pyloricum" . [] oboInOwl:hasDbXref "BTO:0001732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001165 ; owl:annotatedTarget "gastric antrum" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000420" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . _:genid114416 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000420" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000077 . [] oboInOwl:source "ncithesaurus:Pylorus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "UMLS:C0034196" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "pars pylorica" . [] oboInOwl:hasDbXref "FMA:14581", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "pars pylorica gastricae" . [] oboInOwl:hasDbXref "EHDAA2:0001580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "stomach pyloric region" . [] oboInOwl:hasDbXref "Wikipedia:Pylorus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001166 ; owl:annotatedTarget "valvula pylori" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010783" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "anatomical wall of stomach" . _:genid114430 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "anatomical wall of ventriculus" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005487 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "stomach anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "ventriculus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "ventriculus wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001167 ; owl:annotatedTarget "wall of ventriculus" . _:genid114437 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001072, obo:UBERON_0002108 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "An anatomical wall that is part of a small intestine [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Small_Intestinal_Wall_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "UMLS:C1519375" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "anatomical wall of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "anatomical wall of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "small bowel anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "small bowel wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "small intestine anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001168 ; owl:annotatedTarget "wall of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001169 ; owl:annotatedTarget "An anatomical wall that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001169 ; owl:annotatedTarget "anatomical wall of large intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001169 ; owl:annotatedTarget "large intestine anatomical wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget obo:UBERON_0007826 . [] oboInOwl:hasDbXref "Wikipedia:Mesentery#Mesentery_.28proper.29" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "EMAPA:37745" . [] oboInOwl:hasDbXref "Wikipedia:Mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "mesentery (proper)" . [] oboInOwl:hasDbXref "FMA:14643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "mesentery proper" . [] oboInOwl:hasDbXref "FMA:14643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "small intestinal mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001170 ; owl:annotatedTarget "small intestine mesentery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001171 ; owl:annotatedTarget obo:UBERON_0009911 . [] oboInOwl:source "MA", "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001171 ; owl:annotatedTarget _:genid114659 . [] oboInOwl:hasDbXref "MP:0008992" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001171 ; owl:annotatedTarget "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." . [] oboInOwl:source "ncithesaurus:Portal_Lobule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001171 ; owl:annotatedTarget "UMLS:C0682620" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001172 ; owl:annotatedTarget obo:UBERON_0009842 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001172 ; owl:annotatedTarget _:genid114665 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001172 ; owl:annotatedTarget "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." . [] oboInOwl:source "ncithesaurus:Liver_Acinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001172 ; owl:annotatedTarget "UMLS:C0227519" . (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002294 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002394 ] ) . [] oboInOwl:hasDbXref "DOI:10.1002/ar.20664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001173 ; owl:annotatedTarget "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011020" ; oboInOwl:ontology "AAO" ; oboInOwl:source "UBERON:0001173" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001173 ; owl:annotatedTarget "Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO]" . [] oboInOwl:source "ncithesaurus:Biliary_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001173 ; owl:annotatedTarget "UMLS:C0005423" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000018 ; owl:annotatedTarget obo:CL_0000015 . [] oboInOwl:hasDbXref "MA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001173 ; owl:annotatedTarget "biliary tract" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001174 ; owl:annotatedTarget "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005165" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001174 ; owl:annotatedTarget "Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000214" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001174 ; owl:annotatedTarget "The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" . [] oboInOwl:source "ncithesaurus:Common_Bile_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001174 ; owl:annotatedTarget "UMLS:C0009437" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "Reaxys:3904386" . [] oboInOwl:hasDbXref "MESH:D013087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000018 ; owl:annotatedTarget "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." . [] oboInOwl:hasDbXref "Wikipedia:Common_bile_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001174 ; owl:annotatedTarget "ductus choledochus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget obo:UBERON_0003703 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget _:genid114697 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget _:genid114699 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget _:genid114701 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget _:genid114703 . [] oboInOwl:hasDbXref "Wikipedia:Common_hepatic_duct", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000220" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget "The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:source "ncithesaurus:Common_Hepatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget "UMLS:C0019149" . [] oboInOwl:hasDbXref "Wikipedia:Common_hepatic_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001175 ; owl:annotatedTarget "ductus hepaticus communis" . [] oboInOwl:hasDbXref "http://www.medterms.com/script/main/art.asp?articlekey=26034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001176 ; owl:annotatedTarget "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000217" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001176 ; owl:annotatedTarget "The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" . [] oboInOwl:source "ncithesaurus:Right_Hepatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001176 ; owl:annotatedTarget "UMLS:C0227557" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget obo:CL_0000408 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001176 ; owl:annotatedTarget "ductus hepaticus dexter" . [] oboInOwl:hasDbXref "http://www.medterms.com/script/main/art.asp?articlekey=26035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001177 ; owl:annotatedTarget "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000218" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001177 ; owl:annotatedTarget "The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" . [] oboInOwl:source "ncithesaurus:Left_Hepatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001177 ; owl:annotatedTarget "UMLS:C0227560" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001177 ; owl:annotatedTarget "ductus hepaticus sinister" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000019 ; owl:annotatedTarget "A mature male germ cell that develops from a spermatid." . [] oboInOwl:hasDbXref "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001178 ; owl:annotatedTarget "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001178 ; owl:annotatedTarget "visceral serous membrane of peritoneum" . ( ) . _:genid114545 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget _:genid114744 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005604 . [] oboInOwl:hasDbXref "Wikipedia:Peritoneal_cavity", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "Anatomical cavity bounded by visceral and parietal peritoneum." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000852" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/peritoneal+cavity" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "The potential space between the parietal and visceral layers of the peritoneum, which are normally in contact. The peritoneal cavity is divided into the greater and lesser sac. The greater sac is the peritoneal cavity, and the lesser sac is the omental bursa. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000852" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Peritoneal_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "UMLS:C1704247" . [] oboInOwl:hasDbXref "BTO:0001782", "Wikipedia:Peritoneal_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "cavitas peritonealis" . [] oboInOwl:hasDbXref "Wikipedia:Peritoneal_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001179 ; owl:annotatedTarget "saccus serosus peritonei" . ( ) . [] oboInOwl:hasDbXref "MESH:A07.231.114.565.755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001182 ; owl:annotatedTarget "Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra." . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0001182 ; owl:annotatedTarget "Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon" . [] oboInOwl:source "ncithesaurus:Superior_Mesenteric_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001182 ; owl:annotatedTarget "UMLS:C0162861" . [] oboInOwl:hasDbXref "BTO:0002303", "Wikipedia:Superior_mesenteric_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001182 ; owl:annotatedTarget "arteria mesenterica superior" . _:genid114566 a owl:Restriction ; owl:onProperty obo:RO_0002178, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001046, obo:UBERON_0001158 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_mesenteric_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001183 ; owl:annotatedTarget "Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted]." . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001183 ; owl:annotatedTarget "IMA" . [] oboInOwl:source "ncithesaurus:Inferior_Mesenteric_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001183 ; owl:annotatedTarget "UMLS:C0162860" . _:genid114573 oboInOwl:hasDbXref "BTO:0002302", "Wikipedia:Inferior_mesenteric_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001183 ; owl:annotatedTarget "arteria mesenterica inferior" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001046 . [] oboInOwl:notes "dorsal aorta in Kardong" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget _:genid114778 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Renal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010223" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "Artery which supplies blood via branches to the gonads, oviducts, and kidneys.[AAO]" . [] oboInOwl:ontology "Wikipedia" ; oboInOwl:source "Wikipedia:Renal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "The renal arteries normally arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood. Each is directed across the crus of the diaphragm, so as to form nearly a right angle with the aorta. The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys. The arterial supply of the kidneys is variable and there may be one or more renal arteries supplying each kidney. It is located above the renal vein. It has a radius of approximately 0.25cm, 0.26 cm at the root. The measured mean diameter can differ depending on the imaging method used. For example, the diameter was found to be 5.04 ± 0.74 mm using ultrasound, but 5.68 ± 1.19 mm using angiography. [WP,unvetted].[Wikipedia]" . [] oboInOwl:source "ncithesaurus:Renal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "UMLS:C0035065" . [] oboInOwl:hasDbXref "Wikipedia:Renal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "arteria renalis" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001184 ; owl:annotatedTarget "renal arteries" . (obo:UBERON_0001184 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0004539 ] ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001185 ; owl:annotatedTarget "Renal artery that supplies the right kidney." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001185 ; owl:annotatedTarget "EMAPA:37380" . [] oboInOwl:source "ncithesaurus:Right_Renal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001185 ; owl:annotatedTarget "UMLS:C0226332" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001186 ; owl:annotatedTarget "Renal artery that supplies the left kidney." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001186 ; owl:annotatedTarget "EMAPA:37098" . [] oboInOwl:source "ncithesaurus:Left_Renal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001186 ; owl:annotatedTarget "UMLS:C0226333" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "propanedioate" . [] oboInOwl:hasDbXref "MESH:D013093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000020 ; owl:annotatedTarget "An euploid male germ cell of an early stage of spermatogenesis." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget _:genid114804 . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "One of a pair of arteries that is a branch of the abdominal aorta that supplies blood to a male gonad." . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "arteria testicularis" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "internal spermatic" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "internal spermatic arteries" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "internal spermatic artery" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "internal spermatic vessels" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "spermatic arteries" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "spermatic artery" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "spermatic vessels" . [] oboInOwl:hasDbXref "Wikipedia:Testicular_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001187 ; owl:annotatedTarget "testicular arteries" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001188 ; owl:annotatedTarget "A testicular artery that supplies a right testicle." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001188 ; owl:annotatedTarget "EMAPA:37382" . [] oboInOwl:source "ncithesaurus:Right_Spermatic_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001188 ; owl:annotatedTarget "UMLS:C0734076" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001189 ; owl:annotatedTarget "A testicular artery that supplies a left testicle." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001189 ; owl:annotatedTarget "EMAPA:37099" . [] oboInOwl:source "ncithesaurus:Left_Spermatic_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001189 ; owl:annotatedTarget "UMLS:C0734077" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001190 ; owl:annotatedTarget "An artery that supplies an ovary." . [] oboInOwl:source "Wikipedia:Ovarian_artery" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001190 ; owl:annotatedTarget "In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]." . [] oboInOwl:source "ncithesaurus:Ovarian_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001190 ; owl:annotatedTarget "UMLS:C0226411" . [] oboInOwl:hasDbXref "Wikipedia:Ovarian_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001190 ; owl:annotatedTarget "arteria ovarica" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001191 ; owl:annotatedTarget obo:UBERON_0005609 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001191 ; owl:annotatedTarget _:genid114842 . [] oboInOwl:hasDbXref "Wikipedia:Common_iliac_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001191 ; owl:annotatedTarget "The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Common_Iliac_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001191 ; owl:annotatedTarget "UMLS:C1261084" . [] oboInOwl:hasDbXref "Wikipedia:Common_iliac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001191 ; owl:annotatedTarget "arteria iliaca communis" . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_artery_proper", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001193 ; owl:annotatedTarget "An artery that supplies the liver." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005161" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001193 ; owl:annotatedTarget "Artery that supplies blood to the liver.[TAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000021 ; owl:annotatedTarget obo:CL_0000586 . [] oboInOwl:source "ncithesaurus:Hepatic_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001193 ; owl:annotatedTarget "UMLS:C0019145" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001193 ; owl:annotatedTarget "arteria hepatica propria" . [] oboInOwl:hasDbXref "BTO:0004307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001193 ; owl:annotatedTarget "arteria hepatica" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001194 ; owl:annotatedTarget "An artery that supplies the spleen." . _:genid114659 oboInOwl:source "ncithesaurus:Splenic_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001194 ; owl:annotatedTarget "UMLS:C0037996" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001280 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:11023867", "PMID:20454446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000021 ; owl:annotatedTarget "Female germ cell is a germ cell that supports female gamete production." . [] oboInOwl:hasDbXref "Wikipedia:Splenic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001194 ; owl:annotatedTarget "arteria splenica" . [] oboInOwl:hasDbXref "MA:0001991" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001194 ; owl:annotatedTarget "lienal artery" . [] oboInOwl:hasDbXref "Wikipedia:Splenic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001194 ; owl:annotatedTarget "arteria lienalis" . _:genid114665 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945, obo:UBERON_0001280 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "The mucosal layer that lines the stomach." . [] oboInOwl:source "Wikipedia:Gastric_mucosa" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]." . [] oboInOwl:source "ncithesaurus:Gastric_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "UMLS:C0017136" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "mucosa of organ of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "mucosa of organ of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "mucosa of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "mucous membrane of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "organ mucosa of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "organ mucosa of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "stomach mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "stomach mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "stomach organ mucosa" . [] oboInOwl:hasDbXref "FMA:14907", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "tunica mucosa gastricae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "ventriculus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "ventriculus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "ventriculus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "ventriculus organ mucosa" . [] oboInOwl:hasDbXref "BTO:0001308" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "Magenschleimhaut" . [] oboInOwl:hasDbXref "BTO:0001308", "Wikipedia:Gastric_mucosa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001199 ; owl:annotatedTarget "tunica mucosa gastris" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "The fibrous connective tissue layer beneath the stomach mucosa." . [] oboInOwl:source "ncithesaurus:Gastric_Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "UMLS:C0227211" . _:genid114697 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "submucosa of ventriculus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005604 . [] oboInOwl:hasDbXref "FMA:14908", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "tela submucosa gastricae" . _:genid114699 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "ventriculus submucosa" ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001176 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "(-)OOC-CH2-COO(-)" . [] oboInOwl:hasDbXref "BTO:0002110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "submucous layer of stomach" . _:genid114701 oboInOwl:hasDbXref "BTO:0002110" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001200 ; owl:annotatedTarget "tela submucosa ventriculi" ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001177 . (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167 ] ) . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." . [] oboInOwl:source "ncithesaurus:Gastric_Serosal_Surface" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "UMLS:C1517453" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget obo:CL_0000014 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "anatomical wall of stomach serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "anatomical wall of stomach serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "anatomical wall of ventriculus serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "anatomical wall of ventriculus serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "gastric wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "gastric wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of anatomical wall of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of anatomical wall of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of gastric wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of stomach anatomical wall" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of stomach wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of ventriculus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of ventriculus wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of wall of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serosa of wall of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of anatomical wall of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of anatomical wall of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of gastric wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of stomach anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of stomach wall" . [] oboInOwl:hasDbXref "doi:10.1016/j.stem.2012.05.016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000022 ; owl:annotatedTarget "A stem cell that is the precursor of female gametes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of ventriculus anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of ventriculus wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of wall of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "serous membrane of wall of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "stomach anatomical wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "stomach anatomical wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "stomach wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "stomach wall serous membrane" . [] oboInOwl:hasDbXref "FMA:14914", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "tunica serosa gastricae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "ventriculus anatomical wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "ventriculus anatomical wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "ventriculus wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "ventriculus wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "wall of stomach serosa" . _:genid114744 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "wall of stomach serous membrane" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003887 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "wall of ventriculus serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001201 ; owl:annotatedTarget "wall of ventriculus serous membrane" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001202 ; owl:annotatedTarget "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001466" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1525-142x.2000.00076.x", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001202 ; owl:annotatedTarget "(...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Pyloric_Sphincter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001202 ; owl:annotatedTarget "UMLS:C0227238" . [] oboInOwl:hasDbXref "Wikipedia:Pylorus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001202 ; owl:annotatedTarget "pyloric valve" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000023 ; owl:annotatedTarget "A female germ cell that has entered meiosis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "A mucosa that is part of a small intestine [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Small_Intestinal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "UMLS:C0227261" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "mucosa of organ of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "mucosa of organ of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "mucosa of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "mucous membrane of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "organ mucosa of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "organ mucosa of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small bowel mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small bowel mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small bowel mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small bowel organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small intestine mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "small intestine organ mucosa" . _:genid114778 oboInOwl:hasDbXref "FMA:14933", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001204 ; owl:annotatedTarget "tunica mucosa intestini tenuis" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001516 . [] oboInOwl:hasDbXref "Wikipedia:Small_intestinal_submucosa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "Submucosal tissue in the small intestines." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "EMAPA:37564" . [] oboInOwl:source "ncithesaurus:Small_Intestinal_Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "UMLS:C0227268" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "small bowel submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "submucosa of small bowel" . [] oboInOwl:hasDbXref "BTO:0002112" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001205 ; owl:annotatedTarget "tela submucosa intestini tenuis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "A serous membrane that is part of a small intestine [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "EMAPA:37561" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "serosa of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "serous membrane of small bowel" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "MALONATE ION" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "serous membrane of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "small bowel serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "small bowel serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "small intestine serous membrane" . _:genid114804 oboInOwl:hasDbXref "FMA:14938", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001206 ; owl:annotatedTarget "tunica serosa intestini tenuis" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001516 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "A mucosa that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Large_Intestinal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "UMLS:C0734203" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "large intestine mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "large intestine mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "large intestine organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "mucosa of organ of large intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "organ mucosa of large intestine" . [] oboInOwl:hasDbXref "FMA:14969", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001207 ; owl:annotatedTarget "tunica mucosa intestini crassi" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000024 ; owl:annotatedTarget obo:CL_0000021 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001208 ; owl:annotatedTarget "A submucosa that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001208 ; owl:annotatedTarget "EMAPA:37560" . [] oboInOwl:source "ncithesaurus:Large_Intestinal_Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001208 ; owl:annotatedTarget "UMLS:C0734204" . [] oboInOwl:hasDbXref "FMA:14970", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001208 ; owl:annotatedTarget "tela submucosa intestini crassi" . [] oboInOwl:hasDbXref "BTO:0002111" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001208 ; owl:annotatedTarget "submucous layer of large intestine" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000024 ; owl:annotatedTarget "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "A serous membrane that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "EMAPA:37557" . [] oboInOwl:source "ncithesaurus:Large_Intestinal_Serosal_Surface" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "UMLS:C1517727" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "large intestine serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "serous membrane of large intestine" . [] oboInOwl:hasDbXref "FMA:14975", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001209 ; owl:annotatedTarget "tunica serosa intestini crassi" . (obo:UBERON_0011148 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002114 ] ) . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget obo:UBERON_0000414 . [] oboInOwl:notes "compound tubular" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget obo:UBERON_0011148 . [] oboInOwl:source "MA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget _:genid115050 . [] oboInOwl:source "FMA, modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget _:genid115052 . [] oboInOwl:hasDbXref "Wikipedia:Brunner's_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." . [] oboInOwl:source "ISBN:9780521617147" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "Said to be absent outside mammlian (Andrew 1959) but Ziswiler and Farner (1972) noted similar glands at the gastroduodenal junction of some birds" . [] oboInOwl:source "ncithesaurus:Brunner_s_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "UMLS:C0006323" . [] oboInOwl:hasDbXref "FMA:15060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "Brunner's gland" . [] oboInOwl:hasDbXref "FMA:15060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "gland of Brunner" . [] oboInOwl:hasDbXref "BTO:0002376" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "glandula duodenales" . [] oboInOwl:hasDbXref "BTO:0002376" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001212 ; owl:annotatedTarget "glandula duodenales Brunneri" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget obo:UBERON_0004923 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget _:genid115063 . [] oboInOwl:hasDbXref "MGI:csmith", "MGI:rbabiuk", "MP:0008108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005125" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO]" . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "the BTO class refers to a generic villous" . [] oboInOwl:source "ncithesaurus:Villus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "UMLS:C1519988" . [] oboInOwl:hasDbXref "HP:0011473" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "enteric villi" . [] oboInOwl:hasDbXref "HP:0011473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "enteric villous" . [] oboInOwl:hasDbXref "HP:0011473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "enteric villus" . [] oboInOwl:hasDbXref "ZFA:0005125" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "intestinal villi" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "villi intestinales" . [] oboInOwl:hasDbXref "BTO:0003121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "villus" . [] oboInOwl:hasDbXref "FMA:15072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "villus intestinalis (intestinum tenue)" . [] oboInOwl:hasDbXref "MA:0001563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "small intestine villus" . [] oboInOwl:hasDbXref "Wikipedia:Intestinal_villus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001213 ; owl:annotatedTarget "villi intestinales" . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001215 ; owl:annotatedTarget _:genid115085 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_mesenteric_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001215 ; owl:annotatedTarget "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Inferior_Mesenteric_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001215 ; owl:annotatedTarget "UMLS:C0226754" . [] oboInOwl:hasDbXref "BTO:0002782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001215 ; owl:annotatedTarget "lower mesenteric vein" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_mesenteric_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001215 ; owl:annotatedTarget "vena mesenterica inferior" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001216 ; owl:annotatedTarget obo:UBERON_0002017 . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001216 ; owl:annotatedTarget _:genid115096 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000027 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "Wikipedia:Jejunal_veins", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001216 ; owl:annotatedTarget "A tributary of the superior mesenteric vein that drains the jejunum." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001216 ; owl:annotatedTarget "EMAPA:37160" . [] oboInOwl:hasDbXref "Wikipedia:Jejunal_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001216 ; owl:annotatedTarget "venae jejunales" . [] oboInOwl:source "FMA", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001217 ; owl:annotatedTarget _:genid115106 . [] oboInOwl:hasDbXref "ncithesaurus:Ileal_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001217 ; owl:annotatedTarget "The veins that drain blood from the ileum into the superior mesenteric vein." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "malo" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000027 ; owl:annotatedTarget "A smooth muscle cell derived from the neural crest." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001217 ; owl:annotatedTarget "EMAPA:37149" . [] oboInOwl:source "ncithesaurus:Ileal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001217 ; owl:annotatedTarget "UMLS:C1301431" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget obo:UBERON_0002461 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget _:genid115118 . [] oboInOwl:hasDbXref "ISBN:9781435464339", "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "The lateral abdominal wall muscle that is deep to the internal oblique." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000845" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/transversus+abdominis" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "One of a pair of transverse abdominal muscles that is the anterolateral muscle of the abdomen, lying immediately under the internal abdominal oblique. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000845" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.193", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Transversus_Abdominis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "UMLS:C0224378" . [] oboInOwl:hasDbXref "FMA:15570", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "musculus transversus abdominis" . [] oboInOwl:hasDbXref "FMA:15570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transverse abdominal" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversis abdominus" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversus abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversalis" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversalis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transverse abdominal" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transverse abdominal muscle" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transverse abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transverse abdominus" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversus" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversus abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversus abdominus" . [] oboInOwl:hasDbXref "Wikipedia:Transversus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001221 ; owl:annotatedTarget "transversus abdominus muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001222 ; owl:annotatedTarget "An ureter that is part of a right side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001222 ; owl:annotatedTarget "EMAPA:37373" . [] oboInOwl:source "ncithesaurus:Right_Ureter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001222 ; owl:annotatedTarget "UMLS:C0227682" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001223 ; owl:annotatedTarget "An ureter that is part of a left side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001223 ; owl:annotatedTarget "EMAPA:37372" . [] oboInOwl:source "ncithesaurus:Left_Ureter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001223 ; owl:annotatedTarget "UMLS:C0227683" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget _:genid115152 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget _:genid115155 . [] oboInOwl:hasDbXref "MP:0004194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." . [] oboInOwl:source "ncithesaurus:Renal_Pelvis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget "UMLS:C0227666" . [] oboInOwl:hasDbXref "Wikipedia:Renal_pelvis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget "p. renallis" . [] oboInOwl:hasDbXref "MP:0004194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001224 ; owl:annotatedTarget "pyelum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001225 ; owl:annotatedTarget _:genid115169 . [] oboInOwl:hasDbXref "Wikipedia:Renal_cortex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001225 ; owl:annotatedTarget "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000029 ; owl:annotatedTarget obo:CL_0000540 . [] oboInOwl:source "ncithesaurus:Renal_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001225 ; owl:annotatedTarget "UMLS:C0022655" . [] oboInOwl:hasDbXref "FMA:15581", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001225 ; owl:annotatedTarget "cortex renalis" . [] oboInOwl:hasDbXref "http://anatomy.uams.edu/anatomyhtml/kidney.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001228 ; owl:annotatedTarget "Tip of renal pyramid projecting into a minor calyx." . [] oboInOwl:source "ncithesaurus:Renal_Papilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001228 ; owl:annotatedTarget "UMLS:C0022666" . [] oboInOwl:hasDbXref "MP:0011303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001228 ; owl:annotatedTarget "kidney papilla" . [] oboInOwl:source "MA", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget _:genid115182 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget _:genid115184 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002827" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron." . [] oboInOwl:date_retrieved "2012-11-28" ; oboInOwl:external_class "BTO:0000333" ; oboInOwl:ontology "BTO" ; oboInOwl:source "BTO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney[BTO]" . [] oboInOwl:date_retrieved "2012-11-28" ; oboInOwl:external_class "XAO:0000146" ; oboInOwl:ontology "XAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated. Paired highly vascularized structures of the pronephros, responsible for blood filtration.[XAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005281" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "The part of the nephron that filters blood.[TAO]" . [] oboInOwl:source "ncithesaurus:Renal_Corpuscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "UMLS:C0227635" . [] oboInOwl:hasDbXref "MA:0000376" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "Malphigian corpuscle" . [] oboInOwl:hasDbXref "ZFA:0005281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "Malpighian corpuscle" . [] oboInOwl:hasDbXref "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000031 ; owl:annotatedTarget "A cell that will develop into a neuron often after a migration phase." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "corpusculum renale" . [] oboInOwl:hasDbXref "Wikipedia:Renal_corpuscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "corpusculum renis" . [] oboInOwl:hasDbXref "MA:0000376" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "cortical renal corpuscle" . [] oboInOwl:hasDbXref "Wikipedia:Renal_corpuscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001229 ; owl:annotatedTarget "kidney corpuscle" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget _:genid115201 . [] oboInOwl:hasDbXref "MGI:pvb", "MP:0002828", "Wikipedia:Bowman%27s_capsule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010526" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Anatomical structure found in the kidney consisting of an expanded end of a kidney tubule surrounding a glomerulus and is the major site of filtration.[AAO]" . [] oboInOwl:source "ncithesaurus:Bowman_s_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "UMLS:C0524448" . [] oboInOwl:hasDbXref "http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Bowman's capsule" . [] oboInOwl:hasDbXref "KUPO:0001001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Bowmans capsule" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "capsula glomerularis" . [] oboInOwl:hasDbXref "TAO:0005254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "renal glomerular capsule" . [] oboInOwl:hasDbXref "TAO:0005254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Bowman's capsule" . [] oboInOwl:hasDbXref "BTO:0002297" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Malphigian capsule" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Malpighian capsule" . [] oboInOwl:hasDbXref "BTO:0002297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Mueller capsule" . [] oboInOwl:hasDbXref "BTO:0002297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "Muellerian capsule" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "malonate" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "capsula glomeruli" . [] oboInOwl:hasDbXref "TAO:0005310" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001230 ; owl:annotatedTarget "pronephric glomerular capsule" . [] oboInOwl:source "GO", "MA", "ZFA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget _:genid115218 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget obo:UBERON_0009773 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget _:genid115224 . [] oboInOwl:notes "checkme" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget _:genid115226 . [] oboInOwl:hasDbXref "GO:0072078", "Wikipedia:Renal_tubule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget "An epithelial tube that is part of the nephron, the functional part of the kidney." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget "note that in ISBN:0073040584 (Vertebrates, Kardong), the uriniferous tubule contains the nephron, so we have a separate class, rather than using a synonym, as in MA" . [] oboInOwl:source "ncithesaurus:Renal_Tubule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget "UMLS:C0022674" . [] oboInOwl:hasDbXref "GAID:433" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget "kidney tubule" . [] oboInOwl:hasDbXref "MA:0000377" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001231 ; owl:annotatedTarget "uriniferous tubule" . [] oboInOwl:notes "checkme" ; oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget _:genid115234 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget _:genid115237 . [] oboInOwl:hasDbXref "GO:0072044", "Wikipedia:Collecting_tubule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005294" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "Renal duct that collects the output from renal tubules.[TAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "in ISBN:0073040584 (Vertebrates, Kardong), the nephron is adjacent to the collecting tubule, consistent with FMA, but not GO. Wikipedia says: Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron" . [] oboInOwl:hasDbXref "GO:0072044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "collecting duct" . [] oboInOwl:hasDbXref "FMA:15628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "renal collecting tubule" . [] oboInOwl:hasDbXref "Wikipedia:Connecting_tubule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "tubulus renalis arcuatus" . [] oboInOwl:hasDbXref "Wikipedia:Connecting_tubule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "arcuate renal tubule" . [] oboInOwl:hasDbXref "BTO:0000761" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "collecting duct system" . [] oboInOwl:hasDbXref "Wikipedia:Connecting_tubule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "junctional tube" . [] oboInOwl:hasDbXref "EMAPA:28407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001232 ; owl:annotatedTarget "ureteric tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001233 ; owl:annotatedTarget "An adrenal gland that is in the right side of the abdomen." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001233 ; owl:annotatedTarget "In humans, the right adrenal gland is triangular shaped" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001233 ; owl:annotatedTarget "EMAPA:37357" . [] oboInOwl:source "ncithesaurus:Right_Adrenal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001233 ; owl:annotatedTarget "UMLS:C0229559" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001233 ; owl:annotatedTarget "glandula suprarenalis dexter" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D013234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000034 ; owl:annotatedTarget "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001234 ; owl:annotatedTarget "An adrenal gland that is in the left side of the abdomen." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001234 ; owl:annotatedTarget "In humans, the left adrenal gland is semilunar shaped" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001234 ; owl:annotatedTarget "EMAPA:37356" . [] oboInOwl:source "ncithesaurus:Left_Adrenal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001234 ; owl:annotatedTarget "UMLS:C0229560" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001234 ; owl:annotatedTarget "glandula suprarenalis sinister" . ( ) . _:genid115052 a owl:Restriction ; owl:onProperty obo:RO_0001025, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0006704, obo:UBERON_0003332 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001235 ; owl:annotatedTarget _:genid115273 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:llw2", "MP:0008288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001235 ; owl:annotatedTarget "The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001481" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001235 ; owl:annotatedTarget "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Adrenal_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001235 ; owl:annotatedTarget "UMLS:C0001613" . [] oboInOwl:hasDbXref "BTO:0000045", "Wikipedia:Adrenal_cortex" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001235 ; owl:annotatedTarget "cortex glandulae suprarenalis" . _:genid115063 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001277, obo:UBERON_0002369 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget _:genid115287 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget _:genid115289 . [] oboInOwl:source "ISBN:0073040584", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget _:genid115292 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget _:genid115294 . [] oboInOwl:hasDbXref "MESH:A06.407.071.265", "MGI:llw2", "MP:0008289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001378" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Adrenal_Medulla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "UMLS:C0001629" . [] oboInOwl:hasDbXref "FMA:15633", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "medulla glandulae suprarenalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "medulla of adrenal gland" . [] oboInOwl:hasDbXref "BTO:0000049" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001236 ; owl:annotatedTarget "medulla of glandula suprarenalis" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget _:genid115307 . [] oboInOwl:hasDbXref "GOC:Obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "Lamina propria that is part_of the small intestine." . [] oboInOwl:source "ncithesaurus:Small_Intestinal_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "UMLS:C1711325" . _:genid115085 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "lamina propria mucosa of small bowel" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0003713 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "lamina propria mucosa of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "lamina propria mucosae of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "lamina propria of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "small bowel lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "small bowel lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "small bowel lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "small intestine lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001238 ; owl:annotatedTarget "small intestine lamina propria mucosae" . _:genid115096 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0000160, obo:UBERON_0001138 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "Mucosal layer that lines the intestine." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "malonic acid, ion(2-)" . [] oboInOwl:source "ncithesaurus:Intestinal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "UMLS:C0021839" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "bowel mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "bowel mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "bowel mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "bowel organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "intestine mucosa of organ" . _:genid115106 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "intestine mucous membrane" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001138 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "intestine organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "mucosa of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "mucosa of organ of bowel" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000035 ; owl:annotatedTarget "A stem cell that self-renews as well as give rise to a single mature cell type." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "mucosa of organ of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "mucous membrane of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "mucous membrane of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "organ mucosa of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001242 ; owl:annotatedTarget "organ mucosa of intestine" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "A serous membrane that is part of a wall of intestine [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "EMAPA:37619" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "anatomical wall of bowel serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "anatomical wall of bowel serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "anatomical wall of intestine serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "anatomical wall of intestine serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "bowel anatomical wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "bowel anatomical wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "bowel wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "bowel wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestinal wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestinal wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestine anatomical wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestine anatomical wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestine wall serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "intestine wall serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of anatomical wall of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of anatomical wall of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of bowel anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of bowel wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of intestinal wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of intestine anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of intestine wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of wall of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serosa of wall of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of anatomical wall of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of anatomical wall of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of bowel anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of bowel wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of intestinal wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of intestine anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of intestine wall" . _:genid115152 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of wall of bowel" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "serous membrane of wall of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "wall of bowel serosa" . _:genid115155 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "wall of bowel serous membrane" ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000056 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "wall of intestine serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001243 ; owl:annotatedTarget "wall of intestine serous membrane" . [] oboInOwl:hasDbXref "Wikipedia:Anus", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001245 ; owl:annotatedTarget "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." . [] oboInOwl:source "ncithesaurus:Anus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001245 ; owl:annotatedTarget "UMLS:C0003461" . _:genid115169 oboInOwl:source "FMA", "MA-part-of" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001246 ; owl:annotatedTarget obo:UBERON_0003704 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008987 . [] oboInOwl:source "FMA", "MA", "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001246 ; owl:annotatedTarget _:genid115394 . [] oboInOwl:hasDbXref "MP:0009500" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001246 ; owl:annotatedTarget "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." . [] oboInOwl:source "ncithesaurus:Interlobular_Bile_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001246 ; owl:annotatedTarget "UMLS:C0227515" . [] oboInOwl:hasDbXref "MP:0009500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001246 ; owl:annotatedTarget "interlobular ductule" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget _:genid115408 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget _:genid115410 . _:genid115182 oboInOwl:hasDbXref "Wikipedia:Falciform_ligament" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget "A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget "in FMA this is a subclass of mesentery. In MA it is a subclass of ligament, we infer and assert this is a nonskeletal ligament" . _:genid115184 oboInOwl:source "ncithesaurus:Falciform_Ligament" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget "UMLS:C0230240" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007684 . [] oboInOwl:hasDbXref "FMA:15823", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001247 ; owl:annotatedTarget "ligamentum falciforme hepatis" . [] oboInOwl:source "CL:tm", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget _:genid115420 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget _:genid115422 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget _:genid115424 . [] oboInOwl:hasDbXref "CL:tm", "MP:0008470", "https://github.com/obophenotype/uberon/issues/6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur." . [] oboInOwl:source "ncithesaurus:Splenic_Lymphoid_Follicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "UMLS:C1519475" . [] oboInOwl:hasDbXref "FMA:15843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "Malpighian body" . [] oboInOwl:hasDbXref "FMA:15843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "lymphatic follicle of spleen" . [] oboInOwl:hasDbXref "FMA:15843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "lymphoid follicle of spleen" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15792 ; owl:annotatedTarget "propanedioic acid, ion(2-)" . [] oboInOwl:hasDbXref "FMA:15843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "lymphoid nodule of spleen" . _:genid115201 oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "spleen B cell follicle" ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0003094 . [] oboInOwl:hasDbXref "MA:0002672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "spleen lymphoid follicle" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "splenic B cell follicle" . [] oboInOwl:hasDbXref "FMA:15843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "splenic lymphatic follicle" . [] oboInOwl:hasDbXref "MA:0002672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001249 ; owl:annotatedTarget "spleen lymphoid nodule" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0002356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001250 ; owl:annotatedTarget "The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation." . [] oboInOwl:source "ncithesaurus:Splenic_Red_Pulp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001250 ; owl:annotatedTarget "UMLS:C0229687" . [] oboInOwl:hasDbXref "FMA:15844", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001250 ; owl:annotatedTarget "pulpa rubra" . [] oboInOwl:hasDbXref "Wikipedia:Red_pulp" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001250 ; owl:annotatedTarget "pulpa splenica" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001251 ; owl:annotatedTarget "The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001251 ; owl:annotatedTarget "WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line." . [] oboInOwl:hasDbXref "Wikipedia:Marginal_zone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001251 ; owl:annotatedTarget "marginal zone" . _:genid115218 oboInOwl:source "ncithesaurus:Marginal_Zone" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001251 ; owl:annotatedTarget "UMLS:C1711368" ; owl:intersectionOf (obo:UBERON_0003914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 ] ) . [] oboInOwl:hasDbXref "MA:0000755" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001251 ; owl:annotatedTarget "spleen marginal zone" . _:genid115224 oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001252 ; owl:annotatedTarget _:genid115457 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0005009 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001252 ; owl:annotatedTarget "An adventitia that is part of a ureter." . _:genid115226 oboInOwl:hasDbXref "FMA:15892", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001252 ; owl:annotatedTarget "tunica adventitia (ureter)" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003918 . [] oboInOwl:hasDbXref "FMA:15892", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001252 ; owl:annotatedTarget "tunica adventitia ureteris" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget _:genid115467 . _:genid115234 oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget _:genid115469 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001285 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget "A lamina propria that is part of a ureter [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget "lamina propria mucosa of ureter" . _:genid115237 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget "lamina propria mucosae of ureter" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007684 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget "ureter lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001253 ; owl:annotatedTarget "ureter lamina propria mucosae" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget obo:UBERON_0018707 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget _:genid115477 . [] oboInOwl:notes "upper part of UG sinus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget _:genid115480 . [] oboInOwl:hasDbXref "MGI:anna", "Wikipedia:Urinary_bladder" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000740" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000623" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000740" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.577-78", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "bladder" . [] oboInOwl:source "ncithesaurus:Bladder" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "UMLS:C0005682" . [] oboInOwl:hasDbXref "Wikipedia:Urinary_bladder" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "vesica urinaria" . [] oboInOwl:hasDbXref "Wikipedia:Urinary_bladder" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "urocyst" . [] oboInOwl:hasDbXref "BTO:0001418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001255 ; owl:annotatedTarget "vesica" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "An anatomical wall that lines the insider of a urinary bladder." . [] oboInOwl:source "ncithesaurus:Bladder_Wall" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "UMLS:C0458421" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "anatomical wall of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "anatomical wall of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "bladder anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "bladder wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "urinary bladder anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001256 ; owl:annotatedTarget "wall of bladder" . [] oboInOwl:hasDbXref "MP:anna", "Wikipedia:Neck_of_urinary_bladder" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001258 ; owl:annotatedTarget "The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP]." . [] oboInOwl:source "ncithesaurus:Bladder_Neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001258 ; owl:annotatedTarget "UMLS:C0227716" . _:genid115273 oboInOwl:hasDbXref "FMA:15912", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001258 ; owl:annotatedTarget "cervix vesicae" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "FMA:15912", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001258 ; owl:annotatedTarget "collum vesicae" . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_urinary_bladder" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001258 ; owl:annotatedTarget "cervix vesicae urinariae" . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "The mucous membrane lining the urinary bladder." . [] oboInOwl:source "ncithesaurus:Bladder_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "UMLS:C0227691" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "bladder mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "bladder organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "mucosa of bladder" . _:genid115287 oboInOwl:hasDbXref "FMA:15928", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "tunica mucosa (vesica urinaria)" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002082 . [] oboInOwl:hasDbXref "FMA:15928", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "tunica mucosa vesicae" . _:genid115289 oboInOwl:hasDbXref "MP:MP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "tunica mucosa vesicae urinariae" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002083 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001259 ; owl:annotatedTarget "urinary bladder mucous membrane" . (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) . ( ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget _:genid115533 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "A serous membrane that is part of a urinary bladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "bladder serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "serous membrane of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "serous membrane of urinary bladder" . [] oboInOwl:hasDbXref "FMA:15932", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "tunica serosa (vesica urinaria)" . [] oboInOwl:hasDbXref "FMA:15932", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "tunica serosa vesicae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001260 ; owl:annotatedTarget "urinary bladder serous membrane" . _:genid115307 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168, obo:UBERON_0001259 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget _:genid115546 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "A lamina propria that is part of a urinary bladder [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bladder_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "UMLS:C1706967" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "bladder lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "bladder lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "bladder lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "lamina propria mucosa of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "lamina propria mucosa of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "lamina propria mucosae of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "lamina propria mucosae of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "lamina propria of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "urinary bladder lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001261 ; owl:annotatedTarget "urinary bladder lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "An anatomical wall that is part of a intestine [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Intestinal_Wall_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "UMLS:C1708548" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "anatomical wall of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "anatomical wall of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "bowel anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "bowel wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "intestine anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "wall of bowel" . [] oboInOwl:hasDbXref "MA:0001525" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001262 ; owl:annotatedTarget "bowel wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001263 ; owl:annotatedTarget _:genid115578 . [] oboInOwl:hasDbXref "MP:0009145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001263 ; owl:annotatedTarget "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." . [] oboInOwl:source "ncithesaurus:Pancreatic_Acinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001263 ; owl:annotatedTarget "UMLS:C0227578" . [] oboInOwl:hasDbXref "FMA:16011" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001263 ; owl:annotatedTarget "acinus pancreaticus" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001263 ; owl:annotatedTarget "pancreatic acini" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget _:genid115589 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget _:genid115591 . [] oboInOwl:hasDbXref "GO:0031016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010112" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000050" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" . [] oboInOwl:source "PMID:20959416" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)" . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans" . [] oboInOwl:source "ncithesaurus:Pancreas" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001264 ; owl:annotatedTarget "UMLS:C0030274" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001265 ; owl:annotatedTarget _:genid115603 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001265 ; owl:annotatedTarget "A trabecula that is part of a spleen." . [] oboInOwl:source "ncithesaurus:Splenic_Trabecula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001265 ; owl:annotatedTarget "UMLS:C0229688" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001265 ; owl:annotatedTarget "trabeculae of spleen" . [] oboInOwl:hasDbXref "Wikipedia:Femoral_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001267 ; owl:annotatedTarget "The femoral nerve, the largest branch of the lumbar plexus, arises from the ventral divisions of the second, third, and fourth lumbar nerves. It descends through the fibers of the Psoas major, emerging from the muscle at the lower part of its lateral border, and passes down between it and the Iliacus, behind the iliac fascia; it then runs beneath the inguinal ligament, into the thigh, and splits into an anterior and a posterior division. Under the inguinal ligament, it is separated from the femoral artery by a portion of the Psoas major. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Femoral_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001267 ; owl:annotatedTarget "UMLS:C0015808" . [] oboInOwl:hasDbXref "Wikipedia:Femoral_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001267 ; owl:annotatedTarget "nervus femoralis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001268 ; owl:annotatedTarget obo:UBERON_0007794 . [] oboInOwl:hasDbXref "FMA:16515" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001268 ; owl:annotatedTarget "Transudate contained in the peritoneal cavity." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "Phenoscape" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget _:genid115620 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget _:genid115622 . [] oboInOwl:hasDbXref "Wikipedia:Acetabulum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "The acetabulum is a concave surface of the pelvis. The head of the femur meets with the pelvis at the acetabulum, forming the hip joint. There are three bones of the os coxae (hip bone) that come together to form the acetabulum. Contributing a little more than two-fifths of the structure is the ischium, which provides lower and side boundaries to the acetabulum. The ilium forms the upper boundary, providing a little less than two-fifths of the structure of the acetabulum. The rest is formed by the pubis, near the midline. It is bounded by a prominent uneven rim, which is thick and strong above, and serves for the attachment of the acetabular labrum, which reduces its opening, and deepens the surface for formation of the hip joint. At the lower part of the acetabulum is the acetabular notch, which is continuous with a circular depression, the acetabular fossa, at the bottom of the cavity of the acetabulum. The rest of the acetabulum is formed by a curved, crescent-moon shaped surface, the lunate surface, where the joint is made with the head of the femur. Its counterpart in the pectoral girdle is the glenoid fossa.[WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000770" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "Cavity for the articulation of the proximal bone of the hind limb.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000974" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature04119 Boisvert CA, The pelvic fin and girdle of Panderichthys and the origin of tetrapod locomotion. Nature (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "During the transformation from the osteolepiform fins to tetrapod limbs, the appendages and girdles underwent a number of radical changes. The pelvic girdle became a weight-bearing structure by evolution of an ischium, a full mesio-ventral contact between the two sides of the girdle, an ilium, and a contact between the vertebral column and the girdle through a sacral rib. Fore- and hindlimbs shifted laterally by reorientation of the glenoid and the acetabulum.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "In reptiles and in birds, the acetabula are deep sockets." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "whilst WP defines this as a surface, MA treats it as a bone. There are other FMA classes that may be better suited to representing the surface." . [] oboInOwl:source "ncithesaurus:Acetabulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "UMLS:C0000962" . [] oboInOwl:hasDbXref "VHOG:0000974" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "acetabular region" . [] oboInOwl:hasDbXref "MA:0001335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001269 ; owl:annotatedTarget "acetabulum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001270 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/bony+pelvis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001270 ; owl:annotatedTarget "A ring of bone formed by the sacrum and the first few coccygeal vertebrae as the roof, the pubis and ischia as the floor and the ilia and the acetabular part of the ischia as the walls." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001270 ; owl:annotatedTarget "in FMA, this is part of the axial skeletal system" . [] oboInOwl:hasDbXref "FMA:16580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001270 ; owl:annotatedTarget "skeletal system of pelvis" . (obo:UBERON_0007823 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15801 ; owl:annotatedTarget "(2R)-2-hydroxypentanedioate" . [] oboInOwl:hasDbXref "DOI:10.1002/dvdy.22617", "FMA:16581", "FMA:23217", "UBERONREF:0000003", "https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001271 ; owl:annotatedTarget "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000304" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001271 ; owl:annotatedTarget "Subdivision of lower limb or fin which links the limb/fin to the body[FMA,modified]. There is only one instance of the pelvic girdle region per organism.[VSAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001271 ; owl:annotatedTarget "EMAPA:37862" . [] oboInOwl:source "ncithesaurus:Pelvic_Girdle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001271 ; owl:annotatedTarget "UMLS:C0684083" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001271 ; owl:annotatedTarget "pelvic girdle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget obo:UBERON_0010428 . _:genid115408 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget _:genid115652 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002095 . [] oboInOwl:hasDbXref "Wikipedia:Hip_bone", "https://github.com/obophenotype/uberon/issues/290", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]." . _:genid115410 oboInOwl:source "WP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "The hip/pelvic bone/basipterygium first appears in fishes, where it consists of a simple, usually triangular bone, to which the pelvic fin articulates. The hip bones on each side usually connect with each other at the forward end, and are even solidly fused in lungfishes and sharks, but they never attach to the vertebral column" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005626 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "in FMA this is a paired structure. NCITA has 'pelvic bone' but this is the *superclass* of ilium/ischium/pubis. The MA class 'pelvis bone' is actually a superclass of 'pelvic girdle bone' and caudal/sacral vertebra." . [] oboInOwl:hasDbXref "FMA:16585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "bone of pelvic girdle" . [] oboInOwl:hasDbXref "FMA:16585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "coxal bone" . [] oboInOwl:hasDbXref "FMA:16585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "hip bone" . [] oboInOwl:hasDbXref "FMA:16585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "innominate bone" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "os coxa" . [] oboInOwl:hasDbXref "FMA:16585", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "os coxae" . [] oboInOwl:hasDbXref "FMA:16585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "pelvic bone" . [] oboInOwl:hasDbXref "Wikipedia:Hip_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001272 ; owl:annotatedTarget "os innominatum" . _:genid115420 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015054 _:genid115422 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001959 . _:genid115422 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481, obo:UBERON_0006561 . _:genid115424 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0007832, obo:UBERON_1000024 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget _:genid115671 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget _:genid115673 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget _:genid115676 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/105", "https://github.com/obophenotype/uberon/issues/60" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "Paired endochondral bone that is the dorsal-most of the pelvic bones, offering attachment areas for gluteal muscles on its main surface [PHENOSCAPE:ad]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000037 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000772" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "Paired, rodlike endochondral bones that constitute the anterior pelvic girdle.[AAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "All reptiles have an ilium except snakes, although some snake species have a tiny bone which is considered to be an ilium" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "this is_a hip bone in MA." . [] oboInOwl:source "ncithesaurus:Ilium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "UMLS:C0020889" . [] oboInOwl:hasDbXref "EMAPA:18726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "iliac bone" . [] oboInOwl:hasDbXref "FMA:16589", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001273 ; owl:annotatedTarget "os ilium" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000037 ; owl:annotatedTarget "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget obo:UBERON_0007830 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget obo:UBERON_0008202 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget _:genid115694 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget _:genid115697 . [] oboInOwl:hasDbXref "VSAO:0005006", "VSAO:NI", "Wikipedia:Ischium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000860" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "Paired bones of endochondral origin that constitute the posterior elements of the pelvic girdle. They are synostotically fused to each other and form the posterior part of the acetabulum.[AAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "this is_a hip bone in MA; in FMA it is a zone of bone organ." . [] oboInOwl:source "ncithesaurus:Ischium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "UMLS:C0022122" . [] oboInOwl:hasDbXref "EMAPA:18727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "ischial bone" . [] oboInOwl:hasDbXref "AAO:0000860", "Wikipedia:Ischium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001274 ; owl:annotatedTarget "os ischii" . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget obo:UBERON_0007830 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget obo:UBERON_0008202 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget _:genid115713 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget _:genid115715 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/68" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "A paired endochondral bone making up the anteroventral region of the tripartite pelvic girdle forming part of the ventral edge of the acetabulum. The origin site of many proximal hindlimb muscles. [PHENOSCAPE:ad]." . _:genid115467 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000861" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "Paired, cartilaginous (ocassionally calcified) elements that form the ventral portion of the pelvic girdle. Each is located ventral to the acetabulum between the anteroventral margin of the ischium and the posteroventral margin of the illium. When the element calcifies or ossifies, its articulation with adjacent elements is difficult to distinguish. Both pubes are synchondrotically fused to one another.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004980 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "isa bone zone in FMA" . _:genid115469 oboInOwl:source "ncithesaurus:Pubic_Bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "UMLS:C0034014" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009916 . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000038 ; owl:annotatedTarget "A progenitor cell committed to the erythroid lineage." . [] oboInOwl:hasDbXref "Wikipedia:Pubis_(bone)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "os pubis" . [] oboInOwl:hasDbXref "Wikipedia:Pubis_(bone)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "pubic bone" . [] oboInOwl:hasDbXref "Wikipedia:Pubis_(bone)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001275 ; owl:annotatedTarget "pubis bone" . _:genid115477 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001199, obo:UBERON_0001556 . [] oboInOwl:hasDbXref "MP:0000471" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "The epithelial layer of the stomach ." . _:genid115480 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "in FMA this is classified as simple columnar, MA divides this into squamous and glandular" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000164 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "epithelial tissue of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "epithelial tissue of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "epithelium of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "stomach epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "stomach epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "ventriculus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "ventriculus epithelium" . [] oboInOwl:hasDbXref "BTO:0000500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001276 ; owl:annotatedTarget "gastric epithelium" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000039 ; owl:annotatedTarget "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "Epithelial layer that lines the intestine." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005124" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO]" . [] oboInOwl:source "ncithesaurus:Intestinal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "UMLS:C0226890" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "bowel epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "bowel epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15801 ; owl:annotatedTarget "(R)-2-hydroxyglutarate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "epithelial tissue of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "epithelial tissue of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "epithelium of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "epithelium of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "intestine epithelial tissue" . [] oboInOwl:hasDbXref "ZFA:0005124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001277 ; owl:annotatedTarget "villous epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001278 ; owl:annotatedTarget "An epithelium that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001278 ; owl:annotatedTarget "epithelial tissue of large intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001278 ; owl:annotatedTarget "large intestine epithelial tissue" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0008993", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001279 ; owl:annotatedTarget "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." . [] oboInOwl:source "ncithesaurus:Portal_Triad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001279 ; owl:annotatedTarget "UMLS:C0227514" . [] oboInOwl:hasDbXref "Wikipedia:Portal_triad" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001279 ; owl:annotatedTarget "trias hepatica" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget _:genid115780 . [] oboInOwl:hasDbXref "MP:0008986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "The functional units of the liver including the lobules." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000539" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/ar.20524 Hardman RC, Volz DC, Kullman SW, Hinton DE, An in vivo look at vertebrate liver architecture: three-dimensional reconstruction from Medaka (Oryzias latipes). The Anatomical Record (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:17540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "hepatic parenchyma" . [] oboInOwl:hasDbXref "XAO:0000454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "liver parenchyme" . [] oboInOwl:hasDbXref "FMA:17540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "parenchyma of liver" . _:genid115533 oboInOwl:hasDbXref "VHOG:0000539" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001280 ; owl:annotatedTarget "hepatic parenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget _:genid115794 . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_sinusoid", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000708" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Hepatic_Sinusoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "UMLS:C0227523" . _:genid115546 oboInOwl:hasDbXref "EHDAA2:0000999" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "liver hepatic sinusoids" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "liver sinusoidal blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "sinusoid of liver" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "sinusoidal blood vessel of liver" . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_sinusoid" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001281 ; owl:annotatedTarget "vas sinusoideum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget obo:UBERON_0003704 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget _:genid115808 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget _:genid115810 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009499" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." . [] oboInOwl:source "ncithesaurus:Canal_of_Hering" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "UMLS:C0227517" . [] oboInOwl:hasDbXref "FMA:17545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "canal of Herring" . [] oboInOwl:hasDbXref "FMA:17545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "cholangiole" . [] oboInOwl:hasDbXref "FMA:17545", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "ductus interlobularis bilifer" . [] oboInOwl:hasDbXref "Wikipedia:Canals_of_Hering" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "canals of Hering" . [] oboInOwl:hasDbXref "Wikipedia:Canals_of_Hering" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "duct of Herring" . [] oboInOwl:hasDbXref "Wikipedia:Canals_of_Hering" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001282 ; owl:annotatedTarget "intrahepatic bile ductule" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget _:genid115823 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget _:genid115825 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget _:genid115828 . [] oboInOwl:hasDbXref "PMID:9268568", "Wikipedia:Nephron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002153" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "Functional unit of the kidney that filters waste.[TAO]" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "In the avian kidney, three types of nephron are identified: mammalian-type nephrons with long and short loops of Henle, and reptilian type nephrons (Gambaryan, 1992)" . [] oboInOwl:source "ncithesaurus:Nephron" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "UMLS:C0027713" . [] oboInOwl:hasDbXref "EMAPA:28491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "mature nephron" . [] oboInOwl:hasDbXref "Wikipedia:Nephron" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "nephroneum" . [] oboInOwl:hasDbXref "Wikipedia:Nephron" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001285 ; owl:annotatedTarget "tubulus renalis" . _:genid115578 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000362, obo:UBERON_0007324 . [] oboInOwl:hasDbXref "GO:0072053" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "Innermost region of the mammalian kidney." . [] oboInOwl:source "GO:0072053" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "unique to mammals" . [] oboInOwl:hasDbXref "BTO:0001745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "renal inner medulla" . [] oboInOwl:hasDbXref "FMA:17734", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "zona interna (medullaris renalis)" . [] oboInOwl:hasDbXref "FMA:17734", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "zona interna medullae renalis" . [] oboInOwl:hasDbXref "BTO:0001745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001294 ; owl:annotatedTarget "kidney inner medulla" . _:genid115589 a owl:Restriction ; owl:onProperty obo:RO_0002254, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000995, obo:UBERON_0003923 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget _:genid115850 . _:genid115591 oboInOwl:hasDbXref "MESH:A05.360.319.679.490", "MGI:smb", "MP:0004896" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003924 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001285" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Endometrium" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "The mucous membrane lining the uterus. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001285" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "in FMA this is subdivided into basal and outer" . [] oboInOwl:source "ncithesaurus:Endometrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "UMLS:C0014180" . [] oboInOwl:hasDbXref "FMA:17742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "tunica mucosa (endometrium)" . [] oboInOwl:hasDbXref "Wikipedia:Endometrium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "tunica mucosa uteri" . [] oboInOwl:hasDbXref "BTO:0001422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "uterine endometrium" . [] oboInOwl:hasDbXref "BTO:0001422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001295 ; owl:annotatedTarget "uterine mucous membrane" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15801 ; owl:annotatedTarget "(R)-2-hydroxyglutarate" . ( ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget _:genid115866 . [] oboInOwl:hasDbXref "Wikipedia:Perimetrium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "Outer serosa layer of the uterus." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "EMAPA:37792" . [] oboInOwl:source "ncithesaurus:Perimetrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "UMLS:C0227824" . [] oboInOwl:hasDbXref "Wikipedia:Perimetrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "perimetrium" . [] oboInOwl:hasDbXref "Wikipedia:Perimetrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "serous coat of uterus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "serous membrane of uterus" . [] oboInOwl:hasDbXref "FMA:17744", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "tunica serosa uteri" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001297 ; owl:annotatedTarget "uterus serous membrane" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget _:genid115881 . _:genid115620 oboInOwl:hasDbXref "MGI:anna", "MP:0009102" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget "The conic expansion of the corpus spongiosum that forms the head of the penis." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001273 . [] oboInOwl:hasDbXref "EV:0100108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget "glans" . _:genid115622 oboInOwl:source "ncithesaurus:Glans_Penis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget "UMLS:C0227948" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001486 . [] oboInOwl:hasDbXref "BTO:0003118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget "balanus" . [] oboInOwl:hasDbXref "Wikipedia:Glans_penis" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001299 ; owl:annotatedTarget "coronal sulcus" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget _:genid115890 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002669", "Wikipedia:Scrotum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "The external sac of skin that encloses the testes. It is an extension of the abdomen, and in placentals is located between the penis and anus." . [] oboInOwl:source "PMC1570914" ; oboInOwl:taxon "NCBITaxon:9780" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "In elephants the testes remain in the abdomen" . [] oboInOwl:source "PMC1570914" ; oboInOwl:taxon "NCBITaxon:9363" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "In hedgehogs the testes remain in the inguinal canal" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget obo:CL_0002194 . [] oboInOwl:taxon "NCBITaxon:9606" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "In humans and some other mammals, the base of the scrotum becomes covered with pubic hair at puberty" . [] oboInOwl:source "PMID:10984412" ; oboInOwl:taxon "NCBITaxon:9263" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "In marsupials, the scrotum is not homologous to the eutherian scrotum, and development is under the control of X-linked genes, not androgens" . [] oboInOwl:source "ISBN:113945742X" ; oboInOwl:taxon "NCBITaxon:9263" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "In marsupials, the scrotum is positioned in the caudal area of the abdomen, in the same position as the pouch in females. It has been suggested that the pouch and marsupial scrotum are sexual homologs, but it is more likely they arise from different primordia in the same morphogenetic field" . [] oboInOwl:source "ncithesaurus:Scrotum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001300 ; owl:annotatedTarget "UMLS:C0036471" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001301 ; owl:annotatedTarget _:genid115899 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001301 ; owl:annotatedTarget _:genid115901 . [] oboInOwl:hasDbXref "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000040 ; owl:annotatedTarget "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." . [] oboInOwl:hasDbXref "MGI:pvb", "MP:0002631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001301 ; owl:annotatedTarget "The elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001301 ; owl:annotatedTarget "A similar, but probably non-homologous, structure is found in cartilaginous fishes" . [] oboInOwl:source "ncithesaurus:Epididymis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001301 ; owl:annotatedTarget "UMLS:C0014533" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001302 ; owl:annotatedTarget "A fallopian tube that is part of a right side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001302 ; owl:annotatedTarget "EMAPA:37369" . [] oboInOwl:source "ncithesaurus:Right_Fallopian_Tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001302 ; owl:annotatedTarget "UMLS:C0227900" . _:genid115652 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468, obo:UBERON_0001464 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001303 ; owl:annotatedTarget "A fallopian tube that is part of a left side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001303 ; owl:annotatedTarget "EMAPA:37368" . [] oboInOwl:source "ncithesaurus:Left_Fallopian_Tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001303 ; owl:annotatedTarget "UMLS:C0227902" . [] oboInOwl:hasDbXref "PMID:16923182", "Wikipedia:Germinal_epithelium_(female)", "Wikipedia:Talk:Germinal_epithelium_(female)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "Layer of simple cuboidal cells covering surface of ovary[WP]." . [] oboInOwl:source "ncithesaurus:Ovarian_Surface_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "UMLS:C0227875" . [] oboInOwl:hasDbXref "Wikipedia:Germinal_epithelium_(female)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "germinal epithelium (female)" . [] oboInOwl:hasDbXref "BTO:0004483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "ovarian surface epithelium" . [] oboInOwl:hasDbXref "EMAPA:17384" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "female coelomic epithelium" . [] oboInOwl:hasDbXref "EMAPA:17963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001304 ; owl:annotatedTarget "ovary surface epithelium" . _:genid115671 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001307 ; owl:annotatedTarget "A capsule that surrounds a female gonad." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001272 . [] oboInOwl:source "ncithesaurus:Ovarian_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001307 ; owl:annotatedTarget "UMLS:C0227877" . _:genid115673 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001191, obo:UBERON_0007832 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001308 ; owl:annotatedTarget obo:UBERON_0005609 . [] oboInOwl:hasDbXref "Wikipedia:External_iliac_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001308 ; owl:annotatedTarget "The external iliac artery is a large artery in the pelvic region that carries blood to the lower limb. The external iliac artery is a paired artery, meaning there is one on each side of the body: a right external iliac artery and left external iliac artery. The external iliac artery is accompanied by the external iliac vein, which is located posterior to the artery. [WP,unvetted]." . _:genid115676 oboInOwl:source "ncithesaurus:External_Iliac_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001308 ; owl:annotatedTarget "UMLS:C0226398" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010714 . [] oboInOwl:hasDbXref "Wikipedia:External_iliac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001308 ; owl:annotatedTarget "arteria iliaca externa" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001309 ; owl:annotatedTarget obo:UBERON_0005609 . [] oboInOwl:hasDbXref "Wikipedia:Internal_iliac_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001309 ; owl:annotatedTarget "The internal iliac artery (formerly known as the hypogastric artery) is the main artery of the pelvis. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Internal_Iliac_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001309 ; owl:annotatedTarget "UMLS:C0226364" . [] oboInOwl:hasDbXref "Wikipedia:Internal_iliac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001309 ; owl:annotatedTarget "arteria iliaca interna" . [] oboInOwl:hasDbXref "BTO:0004667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001309 ; owl:annotatedTarget "hypogastric artery" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001310 ; owl:annotatedTarget _:genid115951 . [] oboInOwl:hasDbXref "Wikipedia:Umbilical_artery", "https://github.com/obophenotype/uberon/issues/328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001310 ; owl:annotatedTarget "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Umbilical_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001310 ; owl:annotatedTarget "UMLS:C0041632" . [] oboInOwl:hasDbXref "Wikipedia:Umbilical_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001310 ; owl:annotatedTarget "a. umbilicalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "An artery that supplies blood to the upper urinary bladder." . _:genid115694 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "EMAPA:37123" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:source "ncithesaurus:Superior_Vesical_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "UMLS:C0226376" . [] oboInOwl:hasDbXref "Wikipedia:Superior_vesical_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "arteria vesicali superior" . _:genid115697 oboInOwl:hasDbXref "Wikipedia:Superior_vesical_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "arteria vesicalis superior" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006254 . [] oboInOwl:hasDbXref "Wikipedia:Superior_vesical_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001312 ; owl:annotatedTarget "arteriae vesicales superiores" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15841 ; owl:annotatedTarget "Polypeptide" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001316 ; owl:annotatedTarget obo:UBERON_0005610 . [] oboInOwl:hasDbXref "Wikipedia:External_iliac_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001316 ; owl:annotatedTarget "A large vein that connects the femoral vein to the common iliac vein. Their origin is at the inferior margin of the inguinal ligaments and they terminate when they join the internal iliac veins (to form the common iliac veins). Both external iliac veins are accompanied along their course by external iliac arteries. [WP,modified]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001316 ; owl:annotatedTarget "EMAPA:37144" . [] oboInOwl:source "ncithesaurus:External_Iliac_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001316 ; owl:annotatedTarget "UMLS:C0226761" . [] oboInOwl:hasDbXref "Wikipedia:External_iliac_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001316 ; owl:annotatedTarget "vena iliaca externa" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget obo:UBERON_0005610 . [] oboInOwl:hasDbXref "Wikipedia:Internal_iliac_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "A vein that begins near the upper part of the greater sciatic foramen, passes upward behind and slightly medial to the hypogastric artery and, at the brim of the pelvis, joins with the external iliac to form the common iliac vein. [WP,unvetted]." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000048 ; owl:annotatedTarget "A stem cell that can give rise to multiple lineages of cells." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "EMAPA:37148" . [] oboInOwl:source "ncithesaurus:Internal_Iliac_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "UMLS:C0226764" . [] oboInOwl:hasDbXref "MA:0002139", "Wikipedia:Internal_iliac_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "hypogastric vein" . _:genid115713 oboInOwl:hasDbXref "Wikipedia:Internal_iliac_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "v. hypogastrica" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001272 . [] oboInOwl:hasDbXref "Wikipedia:Internal_iliac_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001317 ; owl:annotatedTarget "v. iliaca interna" . _:genid115715 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001319 ; owl:annotatedTarget _:genid115987 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:hasDbXref "Wikipedia:Vaginal_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001319 ; owl:annotatedTarget "One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001319 ; owl:annotatedTarget "EMAPA:37796" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001319 ; owl:annotatedTarget "vagina vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001319 ; owl:annotatedTarget "vein of vagina" . [] oboInOwl:hasDbXref "Wikipedia:Sciatic_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb." . [] oboInOwl:source "BIRNLEX:1133", "ncithesaurus:Sciatic_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "UMLS:C0036394" . [] oboInOwl:hasDbXref "Wikipedia:Sciatic_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "ischiadic nerve" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0878932437", "MESH:D023461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." . [] oboInOwl:hasDbXref "Wikipedia:Sciatic_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "ischiatic nerve" . [] oboInOwl:hasDbXref "BTO:0001221", "Wikipedia:Sciatic_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "nervus ischiadicus" . [] oboInOwl:hasDbXref "BTO:0001221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001322 ; owl:annotatedTarget "nervus sciaticus" . [] oboInOwl:source "FMA", "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001323 ; owl:annotatedTarget _:genid116003 . [] oboInOwl:hasDbXref "Wikipedia:Tibial_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001323 ; owl:annotatedTarget "The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Tibial_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001323 ; owl:annotatedTarget "UMLS:C0040186" . [] oboInOwl:hasDbXref "Wikipedia:Tibial_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001323 ; owl:annotatedTarget "n. tibialis" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CMP" . [] oboInOwl:source "FMAdef" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget _:genid116008 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget obo:UBERON_0003833 . [] oboInOwl:hasDbXref "FMA:19086" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget "Muscle (organ) which is a part of the pelvis. Examples: levator ani,." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget "EMAPA:37481" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget "muscle organ of pelvis" . [] oboInOwl:hasDbXref "FMA:19086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget "pelvic muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001325 ; owl:annotatedTarget "pelvis muscle organ" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CFU-GEMM" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/665" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001328 ; owl:annotatedTarget "A portion of a prostate that forms a lobe." . [] oboInOwl:source "PMID:15163300", "https://github.com/obophenotype/uberon/issues/665" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001328 ; owl:annotatedTarget "Anatomically, the human prostate gland is located between the base of the bladder and the rectum, and it completely surrounds the proximal urethra (Fig. 1A). It is a single alobular structure with central (CZ), peripheral (PZ) and transitional (TZ) zones. In contrast, the mouse prostate is not merged into one compact anatomical structure. It comprises four paired lobes situated circumferentially around the urethra, immediately caudal to the urinary bladder-namely, anterior (AP), dorsal (DP), lateral (LP), and ventral (VP) prostate (Fig. 1B). Often, the dorsal and the lateral lobes are thought of in combination and referred to as the dorsolateral (DLP) lobe as they share a ductal system. The mouse AP is considered analogous to the human CZ, which is rarely a site of neoplastic transformation in humans. The mouse DLP is considered most similar to the human PZ, which is the zone in which most carcinomas arise (Xue et al. 1997). These analogies, however, are limited as they are based solely on descriptive data and need to be re-evaluated using molecular techniques before the relationship between specific mouse prostate lobes and the human prostate zones is definitively asserted (Abate-Shen & Shen 2000). The mouse VP does not have a human homologue, and the human TZ does not have a murine homologue" . [] oboInOwl:source "ncithesaurus:Prostate_Gland_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001328 ; owl:annotatedTarget "UMLS:C0227970" . [] oboInOwl:hasDbXref "Wikipedia:Pampiniform_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001330 ; owl:annotatedTarget "The pampiniform plexus is a network of many small veins found in the male spermatic cord. It is formed by the union of multiple spermatic veins from the back of the testis and tributaries from the epididymis. The veins of the plexus ascend along the cord in front of the ductus deferens. Below the subcutaneous inguinal ring they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins. These again unite to form a single vein, the testicular vein, which opens on the right side into the inferior vena cava, at an acute angle, and on the left side into the left renal vein, at a right angle. The pampinoform plexus forms the chief mass of the cord. In addition to its function in venous return from the testes, the pampiniform plexus also plays a role in the temperature regulation of the testes. It acts as a heat exchanger, cooling blood in adjacent arteries. An abnormal enlargement of the pampiniform plexus is a medical condition called varicocele. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001330 ; owl:annotatedTarget "EMAPA:37385" . [] oboInOwl:hasDbXref "FMA:19607", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001330 ; owl:annotatedTarget "plexus venosus pampiniformis" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "CFU-S" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001331 ; owl:annotatedTarget "A zone of skin that is part of a penis [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:19638" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001331 ; owl:annotatedTarget "penile skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001331 ; owl:annotatedTarget "penis zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001331 ; owl:annotatedTarget "zone of skin of penis" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" . [] oboInOwl:hasDbXref "Wikipedia:Foreskin", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect." . [] oboInOwl:hasDbXref "MA:0000407", "Wikipedia:Foreskin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "prepuce" . [] oboInOwl:hasDbXref "HP:0100587" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "preputium" . [] oboInOwl:source "ncithesaurus:Male_Prepuce" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "UMLS:C0227952" . [] oboInOwl:hasDbXref "FMA:19639" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "penile prepuce" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "multipotential myeloid stem cell" . _:genid115780 oboInOwl:hasDbXref "EMAPA:18989" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "prepuce of male" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008835 . [] oboInOwl:hasDbXref "FMA:19639", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "preputium penis" . [] oboInOwl:hasDbXref "FMA:19639" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "foreskin" . [] oboInOwl:hasDbXref "Wikipedia:Foreskin" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "praeputium" . [] oboInOwl:hasDbXref "Wikipedia:Foreskin" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001332 ; owl:annotatedTarget "prepucium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001333 ; owl:annotatedTarget "A urethra that is part of a male reproductive system." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "myeloid stem cell" . [] oboInOwl:source "ncithesaurus:Male_Urethra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001333 ; owl:annotatedTarget "UMLS:C0458452" . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001334 ; owl:annotatedTarget "A urethra that is part of a female reproductive system." . [] oboInOwl:source "ncithesaurus:Female_Urethra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001334 ; owl:annotatedTarget "UMLS:C0458485" . [] oboInOwl:hasDbXref "BTO:0004088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001334 ; owl:annotatedTarget "urethra feminina" . [] oboInOwl:hasDbXref "BTO:0004088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001334 ; owl:annotatedTarget "urethra muliebris" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15841 ; owl:annotatedTarget "polypeptides" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000049 ; owl:annotatedTarget "pluripotent stem cell (bone marrow)" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001338 ; owl:annotatedTarget obo:UBERON_0000414 . [] oboInOwl:hasDbXref "MP:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001338 ; owl:annotatedTarget "Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001338 ; owl:annotatedTarget "NCIT:C12339 paraurethral gland belongs here" . _:genid115808 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001338 ; owl:annotatedTarget "EMAPA:37784" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001172 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001338 ; owl:annotatedTarget "gland of urethra" . _:genid115810 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000473, obo:UBERON_0004647 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget _:genid116083 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0002216", "https://github.com/obophenotype/uberon/issues/1381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "The tubules in the testes where spermatogenesis occurs." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010399" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "Any of the coiled tubules located in the testes in which spermatozoa are produced.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001363" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/SEMINIFEROUS+TUBULE" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "One of two or three twisted curved tubules in each lobule of the testis in which spermatogenesis occurs. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001363" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.688 and Figure 21-28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "Frogs among amphibians and the amniotes have males with testes that are composed of seminiferous tubules, which differ from ampullae in being long, highly convoluted ductules.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Seminiferous_Tubule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "UMLS:C0036630" . [] oboInOwl:source "ncithesaurus:Seminiferous_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "UMLS:C1519236" . [] oboInOwl:hasDbXref "EMAPA:18685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "seminiferous cord" . [] oboInOwl:hasDbXref "Wikipedia:Seminiferous_tubule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001343 ; owl:annotatedTarget "tubuli seminiferi" . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) . ( ) . _:genid115828 oboInOwl:hasDbXref "MP:0001140" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "The epithelial layer of the vagina." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010532 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "FMA: nonkeratinizing stratified squamous epithelium; BTO: Vaginal epithelium is stratified squamous epithelium having a thickness of 15-200 microns; MA has single subclass (squamous)" . [] oboInOwl:source "ncithesaurus:Vaginal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "UMLS:C0920840" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "epithelial tissue of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "vagina epithelial tissue" . [] oboInOwl:hasDbXref "BTO:0000422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001344 ; owl:annotatedTarget "epithelium, vaginal" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget _:genid116113 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "A collection of caudal vertebrae in the coccygeal region that are fused and part of the bony pelvis." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000731" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_2002", "AAO:Pugener_and_Maglia_2008" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "Small, bony element consisting of several fused, rudimentary caudal vertebrae; near metamorphosis the hypochord fuses to the coccyx, thereby forming the urostyle.[AAO]" . [] oboInOwl:source "WP,unvetted" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "In humans: The coccyx, commonly referred to as the tailbone, is the final segment of the human vertebral column. Comprising three to five separate or fused vertebrae (the coccygeal vertebrae) below the sacrum, it is attached to the sacrum by a fibrocartilaginous joint, the sacrococcygeal symphysis, which permits limited movement between the sacrum and the coccyx." . [] oboInOwl:source "ncithesaurus:Coccyx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "UMLS:C0009194" . [] oboInOwl:hasDbXref "EHDAA2:0000259" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "coccygeal skeleton" . [] oboInOwl:hasDbXref "FMA:20229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "coccygeal vertebrae I-IV" . [] oboInOwl:hasDbXref "FMA:20229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "coccyx [coccygeal vertebrae I-IV]" . _:genid115850 oboInOwl:hasDbXref "FMA:20229", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "coccyx [vertebrae coccygeae I-IV]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000459 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "fused caudal vertebrae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "fused caudal vertebral column" . [] oboInOwl:hasDbXref "FMA:20229", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "os coccygis" . [] oboInOwl:hasDbXref "Wikipedia:Coccyx" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "os coccygis" . [] oboInOwl:hasDbXref "FMA:20229" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001350 ; owl:annotatedTarget "tailbone" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001351 ; owl:annotatedTarget "The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue." . [] oboInOwl:source "ncithesaurus:Lacrimal_Sac" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001351 ; owl:annotatedTarget "UMLS:C0229289" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_sac" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001351 ; owl:annotatedTarget "saccus lacrimalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget _:genid116133 . [] oboInOwl:source "PMID:11237469" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget _:genid116135 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget _:genid116138 . [] oboInOwl:hasDbXref "Wikipedia:External_acoustic_meatus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "subdivision of head in FMA." . _:genid115866 oboInOwl:source "ncithesaurus:External_Acoustic_Meatus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "UMLS:C0013444" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000459 . [] oboInOwl:hasDbXref "Wikipedia:Ear_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "ear canal" . [] oboInOwl:hasDbXref "FMA:61734" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "external acoustic tube" . [] oboInOwl:hasDbXref "FMA:61734" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "external auditory tube" . [] oboInOwl:hasDbXref "EHDAA2:0000460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001352 ; owl:annotatedTarget "auditory meatus" . [] oboInOwl:evidence "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001353 ; owl:annotatedTarget _:genid116148 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001353 ; owl:annotatedTarget "The anus and surrounding regions. Encompasses both internal and external regions, where present." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000395" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001353 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Anal_Region" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001353 ; owl:annotatedTarget "UMLS:C0230120" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000050 ; owl:annotatedTarget obo:CL_0002032 . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Deep_femoral_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001355 ; owl:annotatedTarget "The profunda femoris artery (also known as the deep femoral artery, or the deep artery of the thigh) is a branch of the femoral artery that, as its name suggests, travels more deeply (posteriorly) than the rest of the femoral artery. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001355 ; owl:annotatedTarget "EMAPA:37216" . [] oboInOwl:source "ncithesaurus:Deep_Femoral_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001355 ; owl:annotatedTarget "UMLS:C0226455" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001356 ; owl:annotatedTarget _:genid116166 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000050 ; owl:annotatedTarget "A progenitor cell committed to the megakaryocyte and erythroid lineages." . _:genid115890 oboInOwl:hasDbXref "Wikipedia:Medial_circumflex_femoral_artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001356 ; owl:annotatedTarget "The medial circumflex femoral artery (internal circumflex artery, medial femoral circumflex artery) is an artery in the upper thigh that helps supply blood to the neck of the femur. [WP,unvetted]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011756 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001356 ; owl:annotatedTarget "EMAPA:37670" . [] oboInOwl:hasDbXref "Wikipedia:Medial_circumflex_femoral_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001356 ; owl:annotatedTarget "arteria circumflexa femoris medialis" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget obo:UBERON_0007779 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget _:genid116172 . [] oboInOwl:notes "see notes" ; oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget _:genid116174 . [] oboInOwl:hasDbXref "Wikipedia:Cerebrospinal_fluid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002184" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "Portion of organism substance that is a clear fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.[TAO]" . _:genid115899 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001278" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1021/pr050213t Parada C, Gato A, Bueno D, Mammalian embryonic cerebrospinal fluid proteome has greater apolipoprotein and enzyme pattern complexity than the avian proteome. Journal of Proteome Research (2005)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "In vertebrates, at early stages of Central Nervous System (CNS) development, the architecture of the brain primordium reveals the presence of the cavity of brain vesicles, which is filled by Embryonic Cerebro-Spinal Fluid (E-CSF). (...) Rat and chick E-CSF proteomes are similar, although rat is more complex in certain groups of proteins, e.g., apolipoproteins, which may be involved in the control of neural diversity, and has soluble enzymes present, just like adult human CSF, but unlike chick E-CSF, revealing phylogenetic brain differences between these groups of vertebrates.[uncertain][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006947 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15841 ; owl:annotatedTarget "Polypeptid" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "EHDAA2 models this as developing from CP, which is wrong" . _:genid115901 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "the FMA def states that this is subarachnoid spaces only. ZFA def states subarachnoid spaces and brain ventricles, but not SC (and has part_of to brain). Circulation: It circulates from the lateral ventricles to the foramen of Monro (Interventricular foramen), third ventricle, aqueduct of Sylvius (Cerebral aqueduct), fourth ventricle, foramen of Magendie (Median aperture) and foramina of Luschka (Lateral apertures), subarachnoid space over brain and spinal cord. It should be noted that the CSF moves in a pulsatile manner throughout the CSF system with nearly zero net flow. CSF is reabsorbed into venous sinus blood via arachnoid granulations." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003074 . [] oboInOwl:source "BIRNLEX:1798", "ncithesaurus:Cerebrospinal_Fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "UMLS:C0007806" . [] oboInOwl:hasDbXref "ZFA:0001626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "cerebral spinal fluid" . [] oboInOwl:hasDbXref "Wikipedia:Cerebrospinal_fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "liquor cerebrospinalis" . [] oboInOwl:hasDbXref "BTO:0000237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001359 ; owl:annotatedTarget "spinal fluid" . [] oboInOwl:hasDbXref "Wikipedia:Femoral_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001361 ; owl:annotatedTarget "In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor canal (also known as Hunter's canal) and is a continuation of the popliteal vein. It ends at the inferior margin of the inguinal ligament, where it becomes the external iliac vein. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010237" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001361 ; owl:annotatedTarget "Either of the primary veins in the hindlimbs which collect blood from the hindlimb region.[AAO]" . [] oboInOwl:source "ncithesaurus:Femoral_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001361 ; owl:annotatedTarget "UMLS:C0015809" . [] oboInOwl:hasDbXref "Wikipedia:Femoral_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001361 ; owl:annotatedTarget "vena femoralis" . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget _:genid116192 . [] oboInOwl:hasDbXref "Wikipedia:Great_saphenous_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget "The great saphenous vein (GSV), also greater saphenous vein, is the large (subcutaneous) superficial vein of the leg and thigh. The terms 'safaina' (Greek) and 'el safin' (Arabic) have both been claimed as the origin for the word 'saphenous'. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget "EMAPA:37147" . [] oboInOwl:source "ncithesaurus:Long_Saphenous_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget "UMLS:C0392907" . [] oboInOwl:hasDbXref "BTO:0003271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget "large saphenous vein" . [] oboInOwl:hasDbXref "Wikipedia:Great_saphenous_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001363 ; owl:annotatedTarget "vena saphena magna" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001365 ; owl:annotatedTarget obo:UBERON_0011107 . [] oboInOwl:hasDbXref "Wikipedia:Sacroiliac_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001365 ; owl:annotatedTarget "The joint in the bony pelvis between the sacrum and the ilium of the pelvis, which are joined by strong ligaments." . [] oboInOwl:source "ncithesaurus:Sacroiliac_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001365 ; owl:annotatedTarget "UMLS:C0036036" . [] oboInOwl:hasDbXref "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001366 ; owl:annotatedTarget "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010816" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:JMG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001366 ; owl:annotatedTarget "Peritoneum attached to the abdominal wall.[AAO]" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001366 ; owl:annotatedTarget "parietal serous membrane of peritoneum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget _:genid116224 . [] oboInOwl:notes "combined rectus femoris and vastus muscles" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget _:genid116226 . [] oboInOwl:notes "tibial tuberosity" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget _:genid116228 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "One of the muscles belong to the group consisting of the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000828" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "The quadriceps is a collective term for the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius). [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.391][VHOG]" . [] oboInOwl:source "ncithesaurus:Quadriceps_Muscle_of_the_Thigh" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "UMLS:C0224440" . [] oboInOwl:hasDbXref "BTO:0001149", "Wikipedia:Quadriceps_femoris_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "musculus quadriceps femoris" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000051 ; owl:annotatedTarget "A oligopotent progenitor cell committed to the lymphoid lineage." . [] oboInOwl:hasDbXref "BTO:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "quadricep muscle" . _:genid115951 oboInOwl:hasDbXref "BTO:0001149" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "quadriceps muscle" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002331 . [] oboInOwl:hasDbXref "BTO:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "quadriceps muscle of the thigh" . [] oboInOwl:hasDbXref "BTO:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001377 ; owl:annotatedTarget "quadriceps muscle of thigh" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget _:genid116238 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget _:genid116240 . [] oboInOwl:notes "anterior inferior iliac spine and the exterior surface of the bony ridge which forms the iliac portion of the acetabulum" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget _:genid116242 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget _:genid116244 . [] oboInOwl:hasDbXref "Wikipedia:Rectus_femoris_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget "The Rectus femoris muscle is one of the four quadriceps muscles of the human body. (The others are the vastus medialis, the vastus intermedius, and the vastus lateralis. All four combine to form the quadriceps tendon, which inserts into the patella and continues as the patellar ligament. ) The Rectus femoris is situated in the middle of the front of the thigh; it is fusiform in shape, and its superficial fibers are arranged in a bipenniform manner, the deep fibers running straight down to the deep aponeurosis. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Rectus_Femoris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001378 ; owl:annotatedTarget "UMLS:C0584894" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000052 ; owl:annotatedTarget "A stem cell from which all cells of the body can form." . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001379 ; owl:annotatedTarget _:genid116248 . [] oboInOwl:hasDbXref "Wikipedia:Vastus_lateralis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001379 ; owl:annotatedTarget "The Vastus lateralis (Vastus externus) is the largest part of the Quadriceps femoris. It arises by a broad aponeurosis, which is attached to the upper part of the intertrochanteric line, to the anterior and inferior borders of the greater trochanter, to the lateral lip of the gluteal tuberosity, and to the upper half of the lateral lip of the linea aspera; this aponeurosis covers the upper three-fourths of the muscle, and from its deep surface many fibers take origin. A few additional fibers arise from the tendon of the Glutæus maximus, and from the lateral intermuscular septum between the Vastus lateralis and short head of the Biceps femoris. The fibers form a large fleshy mass, which is attached to a strong aponeurosis, placed on the deep surface of the lower part of the muscle: this aponeurosis becomes contracted and thickened into a flat tendon inserted into the lateral border of the patella, blending with the Quadriceps femoris tendon, and giving an expansion to the capsule of the knee-joint. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Vastus_Lateralis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001379 ; owl:annotatedTarget "UMLS:C0224444" . [] oboInOwl:hasDbXref "BTO:0001563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001379 ; owl:annotatedTarget "vastus externus" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget _:genid116253 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget _:genid116255 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget _:genid116257 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget _:genid116259 . [] oboInOwl:hasDbXref "Wikipedia:Vastus_medialis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget "The vastus medialis, often called the 'teardrop' muscle, is a medially located muscle of the quadriceps. [WP,unvetted]." . [] oboInOwl:hasDbXref "BTO:0004913" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001380 ; owl:annotatedTarget "vastus internus" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget _:genid116267 . [] oboInOwl:hasDbXref "Wikipedia:Leg_muscle", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "A muscle that is part of the region of the hindlimb between the pelvis and ankle." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "leg muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "leg skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "leg skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "muscle of hindlimb zeugopod or stylopod" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000055 ; owl:annotatedTarget "A precursor cell with a limited number of potential fates." . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "muscle of thigh or crus" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "muscle of upper or lower hindlimb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "muscle organ of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001383 ; owl:annotatedTarget "skeletal muscle of leg" . _:genid115987 a owl:Restriction ; owl:onProperty obo:RO_0002376, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001317, obo:UBERON_0001870 . [] oboInOwl:source "MA", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget _:genid116279 . [] oboInOwl:hasDbXref "NLX:143555" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032446", "PMID:21849021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000056 ; owl:annotatedTarget "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." . [] oboInOwl:source "NLX:143555" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html" . [] oboInOwl:date_retrieved "2012-08-31" ; oboInOwl:external_class "MP:0000800" ; oboInOwl:ontology "MP" ; oboInOwl:source "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP]" . [] oboInOwl:source "ncithesaurus:Primary_Motor_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "UMLS:C0026607" . [] oboInOwl:hasDbXref "FMA:224854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "motor cortex" . [] oboInOwl:hasDbXref "BTO:0004348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "Rolando's area" . [] oboInOwl:hasDbXref "BTO:0004348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "excitable area" . [] oboInOwl:hasDbXref "Wikipedia:Primary_motor_cortex" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "gyrus precentralis" . [] oboInOwl:hasDbXref "BTO:0004348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "motor area" . [] oboInOwl:hasDbXref "MP:0000798", "Wikipedia:Primary_motor_cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "prefrontal gyrus" . [] oboInOwl:hasDbXref "BAMS:MOp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "primary motor area" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15841 ; owl:annotatedTarget "polipeptido" . [] oboInOwl:hasDbXref "BAMS:MO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "somatic motor areas" . [] oboInOwl:hasDbXref "BAMS:MO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001384 ; owl:annotatedTarget "somatomotor areas" . [] oboInOwl:notes "medial cuneiform and first metatarsal bones of the foot" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget _:genid116297 . _:genid116003 oboInOwl:notes "medial cuneiform and first metatarsal bones of the foot" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget _:genid116299 ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001322 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget _:genid116301 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget _:genid116303 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget _:genid116305 . [] oboInOwl:hasDbXref "Wikipedia:Tibialis_anterior_muscle", "http://evolutionwiki.org/wiki/M._tibialis_cranialis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "A muscle that originates in the upper two-thirds of the lateral surface of the tibia and inserts into the medial cuneiform and first metatarsal bones of the foot. Its acts to invert the foot. It is situated on the lateral side of the tibia; it is thick and fleshy above, tendinous below. This muscle overlaps the anterior tibial vessels and deep peroneal nerve in the upper part of the leg. [WP,unvetted]. The M. tibialis cranialis is a muscle that flexes the tarsometatarsus. It originates on the craniodistal aspect of the femur and proximal tibiotarsus and inserts on the cranial surface of the tarsometarsus[EvoWiki]." . _:genid116008 oboInOwl:source "ncithesaurus:Tibialis_Cranialis" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "UMLS:C1710423" ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 ] ) . [] oboInOwl:hasDbXref "BTO:0001382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "tibialis anterior muscle" . [] oboInOwl:hasDbXref "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000057 ; owl:annotatedTarget "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." . [] oboInOwl:hasDbXref "MA:0002395" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "tibialis cranialis" . [] oboInOwl:hasDbXref "BTO:0001382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "anterior tibialis" . [] oboInOwl:hasDbXref "BTO:0001382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "ibialis anticus" . [] oboInOwl:hasDbXref "Wikipedia:Tibialis_anterior_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001385 ; owl:annotatedTarget "musculus tibialis anterior" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116314 . [] oboInOwl:notes "tibial nerve from the sciatic specifically nerve roots" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116317 . [] oboInOwl:notes "superior to articular surfaces of lateral condyle of femur and medial condyle of femur" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116320 . [] oboInOwl:notes "tendo calcaneus into mid-posteior calcaneus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116322 . [] oboInOwl:notes "tendo calcaneus into mid-posteior calcaneus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116324 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget _:genid116327 . [] oboInOwl:hasDbXref "ISBN:0073040584", "MP:0013188", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "The most superficial muscle of the triceps surae group, in the posterior portion of the lower hindleg." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001193" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/gastrocnemius" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "The most superficial calf muscle in the posterior part of the leg. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001193" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.393", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "The most prominent ventral muscle of the shank is the gastrocnemius, the 'calf' muscle. In mammals, it has two heads, resulting from the fusion of two different phylogenetic predecessors.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Gastrocnemius_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "UMLS:C0242691" . [] oboInOwl:hasDbXref "BTO:0000506" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "gastrocnemius muscle" . [] oboInOwl:hasDbXref "Wikipedia:Gastrocnemius_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001388 ; owl:annotatedTarget "musculus gastrocnemius" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget _:genid116335 . [] oboInOwl:notes "tibial nerve specifically nerve roots " ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget _:genid116337 . [] oboInOwl:notes "fibula medial border of tibia" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget _:genid116339 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget _:genid116341 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget _:genid116344 . [] oboInOwl:hasDbXref "Wikipedia:Soleus_muscle", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget "A deep muscle of the triceps surae group, in the superficial posterior compartment of the leg." . [] oboInOwl:source "Wikipedia:Soleus" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget obo:NCBITaxon_9611 . [] oboInOwl:source "MP:0003081" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget "responsible for plantar flexion of the foot" . [] oboInOwl:source "ncithesaurus:Soleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget "UMLS:C0242694" . [] oboInOwl:hasDbXref "MA:0002424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001389 ; owl:annotatedTarget "soleus" . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000058 ; owl:annotatedTarget "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001394 ; owl:annotatedTarget "Artery that supplies the axilla." . [] oboInOwl:source "ncithesaurus:Axillary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001394 ; owl:annotatedTarget "UMLS:C0004455" . [] oboInOwl:hasDbXref "Wikipedia:Axillary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001394 ; owl:annotatedTarget "arteria axillaris" . [] oboInOwl:hasDbXref "FMA:22654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001394 ; owl:annotatedTarget "axillary part of subclavian artery" . [] oboInOwl:hasDbXref "Wikipedia:Subscapular_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001397 ; owl:annotatedTarget "The subscapular artery, the largest branch of the axillary artery, arises at the lower border of the Subscapularis, which it follows to the inferior angle of the scapula, where it anastomoses with the lateral thoracic and intercostal arteries and with the descending branch of the transverse cervical, and ends in the neighboring muscles. About 4 cm. from its origin it gives off two branches, first the scapular circumflex artery and then the thoracodorsal artery. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001397 ; owl:annotatedTarget "EMAPA:37116" . [] oboInOwl:source "ncithesaurus:Subscapular_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001397 ; owl:annotatedTarget "UMLS:C0226422" . [] oboInOwl:hasDbXref "Wikipedia:Subscapular_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001397 ; owl:annotatedTarget "arteria subscapularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001415 ; owl:annotatedTarget "A zone of skin that is part of a pelvis [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001415 ; owl:annotatedTarget "EMAPA:37282" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001415 ; owl:annotatedTarget "pelvis zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001415 ; owl:annotatedTarget "zone of skin of pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001416 ; owl:annotatedTarget "A zone of skin that is part of an abdomen [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Abdominal_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001416 ; owl:annotatedTarget "UMLS:C0222166" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001416 ; owl:annotatedTarget "abdomen zone of skin" . [] oboInOwl:hasDbXref "FMA:22988" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001416 ; owl:annotatedTarget "skin of abdomen proper" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001416 ; owl:annotatedTarget "zone of skin of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "A zone of skin that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "EMAPA:37277" . [] oboInOwl:source "ncithesaurus:Neck_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "UMLS:C0205030" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "neck (volume) zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "neck zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "zone of skin of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001417 ; owl:annotatedTarget "zone of skin of neck (volume)" . _:genid116083 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000014 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005297 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001418 ; owl:annotatedTarget "A zone of skin that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001418 ; owl:annotatedTarget "EMAPA:37765" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001418 ; owl:annotatedTarget "thorax zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001418 ; owl:annotatedTarget "zone of skin of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001419 ; owl:annotatedTarget "A zone of skin that is part of a limb [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Skin_of_the_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001419 ; owl:annotatedTarget "UMLS:C1282135" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001419 ; owl:annotatedTarget "limb zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001419 ; owl:annotatedTarget "zone of skin of limb" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15889 ; owl:annotatedTarget "LIPID_MAPS_class:LMST01" . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000034", "MESH:D000565" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000059 ; owl:annotatedTarget "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." . [] oboInOwl:hasDbXref "FMA:23217", "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000305" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "VSAO:0000305" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "EMAPA:37856" . [] oboInOwl:hasDbXref "FMA:23217", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "cingulum membri superioris" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "cingulum membri superioris" . [] oboInOwl:hasDbXref "FMA:23217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "shoulder girdle" . [] oboInOwl:hasDbXref "FMA:23217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001421 ; owl:annotatedTarget "upper limb girdle" . _:genid116113 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001270 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001422 ; owl:annotatedTarget "A lymphatic vessel that is part of a face [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001422 ; owl:annotatedTarget "face lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001422 ; owl:annotatedTarget "face lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001422 ; owl:annotatedTarget "lymph vessel of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001422 ; owl:annotatedTarget "lymphatic vessel of face" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget _:genid116438 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget _:genid116441 . [] oboInOwl:hasDbXref "PHENOSCAPE:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget "The major preaxial endochondral bone in the anterior zeugopod[Phenoscape]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000788" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the lateral side of the ulna. Its upper end articulates with both the humerus and the ulna, whereas the lower articulates with the carpals.[AAO]" . [] oboInOwl:source "ncithesaurus:Radius_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget "UMLS:C0034627" . _:genid116133 oboInOwl:hasDbXref "MA:0001357" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001423 ; owl:annotatedTarget "radius" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 . (obo:UBERON_0015003 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) . _:genid116138 a owl:Restriction ; owl:onProperty obo:BSPO_0001115, obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0010065, obo:UBERON_0010703 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001424 ; owl:annotatedTarget _:genid116451 . [] oboInOwl:hasDbXref "GO_REF:0000034", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000060 ; owl:annotatedTarget "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001424 ; owl:annotatedTarget _:genid116454 . [] oboInOwl:hasDbXref "PHENOSCAPE:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001424 ; owl:annotatedTarget "The major postaxial endochondral bone in the anterior zeugopod[Phenoscape]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000789" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001424 ; owl:annotatedTarget "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the medial (inner) side of the radius. The upper end of the ulna articulates with the lower end of the humerus forming a strong hinge joint with the carpals, whereas the lower articulates with the carpals.[AAO]" . [] oboInOwl:source "ncithesaurus:Ulna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001424 ; owl:annotatedTarget "UMLS:C0041600" . _:genid116148 oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001425 ; owl:annotatedTarget "PL" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000931 . [] oboInOwl:hasDbXref "UBERON:mah", "https://github.com/obophenotype/uberon/issues/112" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "Endochondral proximal carpal bone articulating with the radius." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000790" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "One of two element that constitute the basal row of carpals. It articulates proximally with the radius, mesially with the ulnare (or pars intermedia of the ulnare when the ulnare is fused to the intermedium) and distally with the centrale (also recognized by some authors as element Y). This element originates from one or two condensation centers. Occasionally it may fuse to carpal 5(4), the ulnare, or other elements.[AAO]" . [] oboInOwl:source "MP:0010775,MGI:llw2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "the bone of the hand located at the radial side of the carpus and which articulates with the radius, trapezium, trapezoideum, capitate, and lunate bones" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "EMAPA:37660" . [] oboInOwl:source "ncithesaurus:Scaphoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "UMLS:C0223724" . [] oboInOwl:hasDbXref "Wikipedia:Scaphoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "os naviculare manus" . [] oboInOwl:hasDbXref "Wikipedia:Scaphoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "os scaphoideum" . [] oboInOwl:hasDbXref "MA:0002555", "NCBITaxon:40674", "Wikipedia:Scaphoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "scaphoid" . [] oboInOwl:hasDbXref "Wikipedia:Scaphoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001427 ; owl:annotatedTarget "scaphoideum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget obo:UBERON_0001480 . [] oboInOwl:hasDbXref "UBERON:mah", "https://github.com/obophenotype/uberon/issues/113" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "Endochondral carpal bone articulating with the ulnare and the radiale." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "intermedium" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "EMAPA:37659" . [] oboInOwl:source "ncithesaurus:Lunate_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "UMLS:C0036624" . [] oboInOwl:hasDbXref "VSAO:0005040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "lunar" . _:genid116166 oboInOwl:hasDbXref "MA:0002556", "NCBITaxon:40674" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "lunate" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001355 . [] oboInOwl:hasDbXref "VSAO:0005040" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "os lunatum" . [] oboInOwl:hasDbXref "Wikipedia:Lunate_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001428 ; owl:annotatedTarget "os lunatum" . ( ) . _:genid116174 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002307, obo:UBERON_0015085 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget obo:UBERON_0001481 . [] oboInOwl:hasDbXref "Wikipedia:Trapezium_(bone)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "located between radiale and first metacarpal[VSAO]. in humans - The capitate articulates with 1st metacarpal distally, scaphoid proximally, trapezoid medially, 2nd metacarpal medially" . [] oboInOwl:source "ncithesaurus:Trapezial_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "UMLS:C0223736" . [] oboInOwl:hasDbXref "VSAO:0005043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "distal carpal 1" . [] oboInOwl:hasDbXref "VSAO:0005043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "os trapezium" . [] oboInOwl:hasDbXref "FMA:23721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "trapezial bone" . [] oboInOwl:hasDbXref "VSAO:0005043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "trapezium" . [] oboInOwl:hasDbXref "FMA:23721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "trapezium bone" . [] oboInOwl:hasDbXref "AAO:0010634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "carpal 1" . [] oboInOwl:hasDbXref "MA:0001340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "greater multiangular" . [] oboInOwl:hasDbXref "MA:0001340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001430 ; owl:annotatedTarget "hand distal carpal bone 1" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000064 ; owl:annotatedTarget "A cell that has a filiform extrusion of the cell surface." . _:genid116192 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001361, obo:UBERON_0015088 . [] oboInOwl:hasDbXref "Wikipedia:Trapezoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000848" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "Small element that articulates with the prepollex, metacarpal II(I) and metacarpal III(II). It may be fused to element Y or carpal 3(2).[AAO]" . [] oboInOwl:source "Wikipedia:Trapezoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "The trapezoid bone (lesser multangular bone) is a carpal bone in tetrapods, including humans. It is the smallest bone in the distal row. It may be known by its wedge-shaped form, the broad end of the wedge constituting the dorsal, the narrow end the palmar surface; and by its having four articular facets touching each other, and separated by sharp edges. It is homologous with the 'second distal carpal' of reptiles and amphibians. The etymology derives from the Greek trapezion which means 'irregular quadrilateral,' from tra- 'four' and peza 'foot' or 'edge. ' Literally, 'a little table' from trapeza meaning 'table' and -oeides 'shaped.[Wikipedia:Trapezoid_bone]" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "located in the distal part of the carpus and articulating with the second metacarpal, the distal carpals 1 and 2 and the radiale.[VSAO] in humans - The capitate articulates with 2nd metacarpal distally, scaphoid proximally, trapezium medially, capitate medially[WP] Amphibians: Small element that articulates with the prepollex, metacarpal II(I) and metacarpal III(II). It may be fused to element Y or carpal 3(2)" . [] oboInOwl:source "ncithesaurus:Trapezoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "UMLS:C0223741" . [] oboInOwl:hasDbXref "VSAO:0005044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "distal carpal 2" . [] oboInOwl:hasDbXref "FMA:23724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "lesser multangular bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15889 ; owl:annotatedTarget "Sterol" . [] oboInOwl:hasDbXref "VSAO:0005044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "os trapezoideum" . [] oboInOwl:hasDbXref "VSAO:0005044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "trapezoid" . [] oboInOwl:hasDbXref "FMA:23724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "trapezoid bone" . [] oboInOwl:hasDbXref "AAO:0000848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "carpal 2" . [] oboInOwl:hasDbXref "MA:0001341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "hand distal carpal bone 2" . [] oboInOwl:hasDbXref "MA:0001341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001431 ; owl:annotatedTarget "lesser multiangular" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm", "MESH:D004847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000066 ; owl:annotatedTarget "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." . [] oboInOwl:source "FMA", "palaeos" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget obo:UBERON_0001481 . [] oboInOwl:hasDbXref "Wikipedia:Capitate_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000849" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "Small element that articulates anteriorly with metacarpal III(II). It may be fused to carpals 2(1), 4(3), 5(4), or other elements.[AAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "medially located and articulates with metacarpals 2-4, distal carpal 5 and the intermedium[VSAO] In the human hand, the capitate bone is the largest of the carpal bones, and occupies the center of the wrist - The capitate articulates with seven bones: the scaphoid and lunate proximally, the second metacarpal, third metacarpal, and fourth metacarpal distally, the lesser multangular on the radial side, and the hamate on the ulnar side" . [] oboInOwl:source "ncithesaurus:Capitate_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "UMLS:C0223733" . [] oboInOwl:hasDbXref "MA:0001342" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "capitate" . [] oboInOwl:hasDbXref "FMA:23727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "capitate bone" . [] oboInOwl:hasDbXref "VSAO:0005045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "distal carpal 3" . [] oboInOwl:hasDbXref "FMA:23727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "os magnum (carpus)" . [] oboInOwl:hasDbXref "AAO:0000849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "carpal 3" . [] oboInOwl:hasDbXref "MA:0001342" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "hand distal carpal bone 3" . [] oboInOwl:hasDbXref "VSAO:0005045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "magnum" . _:genid116224 oboInOwl:hasDbXref "Wikipedia:Capitate_bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001432 ; owl:annotatedTarget "os capitatum" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001267 . (obo:UBERON_0015093 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget obo:UBERON_0001481 . [] oboInOwl:hasDbXref "Wikipedia:Hamate_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000850" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "Small element that articulates anteriorly with metacarpal IV(III). It may be fused to carpal 3(2), 5(4), or other elements.[AAO]" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "articulates with the lunar, distal carpal 3, the ulnare as well as metacarpals 4 and 5.[VSAO]. In the human hand the lunate proximally the fourth and fifth metacarpals distally the triangular medially the capitate laterally[WP] Amphibians: Small element that articulates anteriorly with metacarpal IV(III). It may be fused to carpal 3(2), 5(4), or other elements" . [] oboInOwl:source "ncithesaurus:Hamate_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "UMLS:C0560737" . [] oboInOwl:hasDbXref "VSAO:0005046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "distal carpal 4" . [] oboInOwl:hasDbXref "MA:0001343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "hamate" . _:genid116238 oboInOwl:hasDbXref "FMA:23730" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "hamate bone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001377 . [] oboInOwl:hasDbXref "FMA:23730" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "unciform bone" . _:genid116240 oboInOwl:hasDbXref "AAO:0000850" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "carpal 4" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001267 . [] oboInOwl:hasDbXref "MA:0001343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "hand distal carpal bone 4" . _:genid116242 oboInOwl:hasDbXref "VSAO:0005046", "Wikipedia:Hamate_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "os hamatum" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001269 . [] oboInOwl:hasDbXref "MA:0001343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "unciform" . _:genid116244 oboInOwl:hasDbXref "MA:0001343" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001433 ; owl:annotatedTarget "uncinate" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0002463 . ( ) . _:genid116253 oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000027", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001377 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000434" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]" . _:genid116255 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000027" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001267 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000566" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "System that provides physical support to the organism.[AAO]" . _:genid116257 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001254" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1159/000324245 Donoghue PCJ, Sansom IJ, Origin and early evolution of vertebrate skeletonization. Microscopy research and technique (2002)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG]" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000981 . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates" . _:genid116259 oboInOwl:source "ncithesaurus:Skeletal_System" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "UMLS:C0037253" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002446 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000067 ; owl:annotatedTarget "An epithelial cell that has a cilia." . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "set of all bones and joints" . [] oboInOwl:hasDbXref "BTO:0001486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001434 ; owl:annotatedTarget "Skelettsystem" . _:genid116267 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004466, obo:UBERON_0006213 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001435 ; owl:annotatedTarget "A bone that is part of the carpal skeleton. Examples: scaphoid, lunate, capitate[cjm]." . [] oboInOwl:source "Wikipedia:Carpus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001435 ; owl:annotatedTarget "In tetrapods, the carpals is the sole cluster of the bones in the wrist between the radius and ulna and the metacarpus. The bones of the carpus do not belong to individual fingers (or toes in quadrupeds), whereas those of the metacarpus do. The corresponding part of the foot is the tarsus. The carpal bones allow the wrist to move and rotate vertically, horizontally and laterally. In human anatomy, the main role of the carpus is to facilitate effective positioning of the hand and powerful use of the extensors and flexors of the forearm, but the mobility of individual carpal bones increase the freedom of movements at the wrist." . [] oboInOwl:source "ncithesaurus:Carpal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001435 ; owl:annotatedTarget "UMLS:C0007285" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001435 ; owl:annotatedTarget "carpal" . [] oboInOwl:hasDbXref "EMAPA:25056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001435 ; owl:annotatedTarget "carpus bone" . _:genid116279 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001870, obo:UBERON_0010686 . [] oboInOwl:hasDbXref "Wikipedia:Phalanges_of_the_hand", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "A phalanx that is part of a forelimb autopod[Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000947" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the four digits of the manus. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the manus, in a medial to lateral sequence, is 2-2-3-3.[AAO]" . [] oboInOwl:source "ncithesaurus:Hand_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "UMLS:C0223792" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "digitus manus phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "hand digit phalanx" . [] oboInOwl:hasDbXref "MA:0000306" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "hand phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "phalanx of digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "phalanx of digitus manus" . [] oboInOwl:hasDbXref "FMA:23914" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "phalanx of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "phalanx of hand digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "digital bone of manus" . [] oboInOwl:hasDbXref "FMA:23914" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "bone of finger" . [] oboInOwl:hasDbXref "AAO:0000947" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001436 ; owl:annotatedTarget "phalanges of fore digit" . [] oboInOwl:hasDbXref "MESH:A02.835.232.251", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001437 ; owl:annotatedTarget "The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000742" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_2002" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001437 ; owl:annotatedTarget "Cartilaginous expansion at the distal end of an anterior rib or transverse process that serves for the attachment of muscles suspending the pectoral girdle to the vertebral column.[AAO]" . _:genid116297 oboInOwl:source "FMA:24012" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001437 ; owl:annotatedTarget "Subdivision of long bone which forms its expanded proximal or distal articular end; together with other the subdivisions of long bone, it constitutes the long bone. Examples: proximal epiphysis of humerus, distal epiphysis of femur." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001448 . [] oboInOwl:source "ncithesaurus:Long_Bone_Epiphysis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001437 ; owl:annotatedTarget "UMLS:C1708734" . _:genid116299 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001437 ; owl:annotatedTarget "epiphyses" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0010721 . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15889 ; owl:annotatedTarget "sterols" . _:genid116301 a owl:Restriction ; owl:onProperty obo:RO_0002220, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001388, obo:UBERON_0006861 . _:genid116303 oboInOwl:hasDbXref "FMA:24014", "Wikipedia:Metaphysis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001438 ; owl:annotatedTarget "Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]." ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001389 . [] oboInOwl:source "FMA:24014" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001438 ; owl:annotatedTarget "Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]" . _:genid116305 oboInOwl:source "ncithesaurus:Metaphysis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001438 ; owl:annotatedTarget "UMLS:C0222671" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001667 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001438 ; owl:annotatedTarget "metaphyses" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:hdene", "MP:0003797" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae." . [] oboInOwl:source "ncithesaurus:Cortical_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "UMLS:C0222661" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000068 ; owl:annotatedTarget "An epithelial cell that is part of a duct." . [] oboInOwl:hasDbXref "HP:0002753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "bony cortex" . [] oboInOwl:hasDbXref "MA:0001461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "compact bone" . [] oboInOwl:hasDbXref "FMA:24018", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "substantia compacta" . [] oboInOwl:hasDbXref "FMA:24018", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001439 ; owl:annotatedTarget "substantia corticalis" . _:genid116314 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0002102 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001665 . ( ) . _:genid116320 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget _:genid116633 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0009984 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle." . _:genid116322 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000202" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "Skeletal structure of the paired, anterior appendages.[AAO]" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001450 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000202" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" . _:genid116324 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001256" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003701 . [] oboInOwl:hasDbXref "VHOG:0001256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "forelimb skeleton" . [] oboInOwl:hasDbXref "FMA:24142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "free upper limb skeleton" . _:genid116327 oboInOwl:hasDbXref "FMA:24139", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "ossa membri superioris" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001385 . [] oboInOwl:hasDbXref "FMA:24142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "skeleton of free upper limb" . [] oboInOwl:hasDbXref "FMA:24139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "skeleton of upper limb" . [] oboInOwl:hasDbXref "EHDAA2:0002222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "upper limb skeleton" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001440 ; owl:annotatedTarget "wing skeleton" . ( ) . _:genid116337 a owl:Restriction ; owl:onProperty obo:RO_0002005, core:proximally_connected_to ; owl:someValuesFrom obo:UBERON_0001323, obo:UBERON_0007832 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget _:genid116652 . _:genid116339 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "Subdivision of skeleton consisting of all skeletal elements in an hindlimb region." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001446 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000217" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "Skeletal structure of the paired, posterior appendages.[AAO]" . _:genid116341 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000217" ; oboInOwl:ontology "AAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003701 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001255" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:24144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "free lower limb skeleton" . _:genid116344 oboInOwl:hasDbXref "XAO:0003062" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "hind limb skeleton" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001385 . [] oboInOwl:hasDbXref "VSAO:0000152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "hind-limb skeleton" . [] oboInOwl:hasDbXref "VHOG:0001255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "hindlimb skeleton" . [] oboInOwl:hasDbXref "FMA:24140", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "ossa membri inferioris" . [] oboInOwl:hasDbXref "FMA:24144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "skeleton of free lower limb" . [] oboInOwl:hasDbXref "FMA:24140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001441 ; owl:annotatedTarget "skeleton of lower limb" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget _:genid116671 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget obo:UBERON_0001445 . [] oboInOwl:hasDbXref "PHENOSCAPE:MAH", "https://github.com/obophenotype/uberon/issues/74", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape]." . [] oboInOwl:hasDbXref "FMA:24159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "bones of hand" . [] oboInOwl:hasDbXref "EHDAA2:0002227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "hand region skeleton" . [] oboInOwl:hasDbXref "FMA:24159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "hand skeleton" . [] oboInOwl:hasDbXref "FMA:24159", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "ossa manus" . [] oboInOwl:hasDbXref "FMA:24159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "set of bones of hand" . [] oboInOwl:hasDbXref "FMA:24159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "skeleton of hand" . [] oboInOwl:hasDbXref "VSAO:0005020", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "anterior autopodium" . [] oboInOwl:hasDbXref "VSAO:0005020", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001442 ; owl:annotatedTarget "manus" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget obo:UBERON_0009569 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget _:genid116685 . [] oboInOwl:hasDbXref "FMA:9576", "Wikipedia:Chest" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "EMAPA:37232" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000071 ; owl:annotatedTarget obo:CL_0000076 . [] oboInOwl:source "ncithesaurus:Thorax" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "UMLS:C0817096" . [] oboInOwl:source "ncithesaurus:Chest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "UMLS:C1527391" . [] oboInOwl:hasDbXref "FMA:24816", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "pectus" . [] oboInOwl:hasDbXref "MA:0000031" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "thoracic body wall" . [] oboInOwl:hasDbXref "FMA:9576", "Wikipedia:Chest" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001443 ; owl:annotatedTarget "thorax" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000071 ; owl:annotatedTarget "An endothelial cell that lines the vasculature." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget _:genid116699 . [] oboInOwl:hasDbXref "PHENOSCAPE:MAH", "https://github.com/obophenotype/uberon/issues/75", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape]." . [] oboInOwl:hasDbXref "EHDAA2:0002228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "foot region skeleton" . [] oboInOwl:hasDbXref "FMA:24222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "foot skeleton" . [] oboInOwl:hasDbXref "FMA:24222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "set of bones of foot" . [] oboInOwl:hasDbXref "FMA:24222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "skeleton of foot" . [] oboInOwl:hasDbXref "VSAO:0005021", "VSAO:NI" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "pes" . [] oboInOwl:hasDbXref "VSAO:0005021", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001445 ; owl:annotatedTarget "posterior autopodium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001446 ; owl:annotatedTarget obo:UBERON_0002495 . [] oboInOwl:hasDbXref "PHENOSCAPE:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001446 ; owl:annotatedTarget "The major postaxial endochondral bone in the posterior zeugopod[Phenoscape]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000891" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001446 ; owl:annotatedTarget "One of the two long bones of endochondral origin of the hind-epipodium; it is a rather more slender bone than the tibia but of about the same length.[AAO]" . [] oboInOwl:source "ncithesaurus:Fibula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001446 ; owl:annotatedTarget "UMLS:C0016068" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15889 ; owl:annotatedTarget "3-hydroxysteroids" . [] oboInOwl:hasDbXref "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000075 ; owl:annotatedTarget "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia." . [] oboInOwl:source "Wikipedia:Tarsus_(skeleton)" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "In primitive tetrapods, such as Trematops, the tarsus consists of three rows of bones. There are three proximal tarsals, the tibiale, intermedium, and fibulare, named for their points of articulation with the bones of the lower limb. These are followed by a second row of four bones, referred to as the centralia (singular: centrale), and then a row of five distal tarsals, each articulating with a single metatarsal. In the great majority of tetrapods, including all of those alive today, this simple pattern is modified by the loss and fusion of various of the bones.[3] In reptiles and mammals, there are normally just two proximal tarsals, the calcaneus (equivalent to the amphibian fibulare) and the talus (probably derived from a fusion of multiple bones). In mammals, including humans, the talus forms a hinge joint with the tibia, a feature especially well developed in the artiodactyls. The calcaneus is also modified, forming a heel for the attachment of the Achilles tendon. Neither of these adaptations is found in reptiles, which have a relatively simple structure to both bones.[3] The fifth distal tarsal disappears relatively early in evolution, with the remainder becoming the cuneiform and cuboid bones. Reptiles usually retain two centralia, while mammals typically have only one (the navicular).[3] In birds, the tarsus has disappeared, with the proximal tarsals having fused with the tibia, the centralia having disappeared, and the distal bones having fused with the metatarsals to form a single tarsometatarsus bone, effectively giving the leg a third segment" . [] oboInOwl:source "ncithesaurus:Tarsal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "UMLS:C0039316" . [] oboInOwl:hasDbXref "FMA:24491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "ankle bone" . [] oboInOwl:hasDbXref "FMA:24491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "bone of ankle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "bone of tarsal skeleton" . [] oboInOwl:hasDbXref "FMA:24491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "bone of tarsus" . [] oboInOwl:hasDbXref "FMA:71339", "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "ossa tarsalia" . [] oboInOwl:hasDbXref "FMA:71339", "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "ossa tarsi" . [] oboInOwl:hasDbXref "BTO:0002343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "bony tarsus" . [] oboInOwl:hasDbXref "AAO:0000220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "hind mesopodium" . [] oboInOwl:hasDbXref "BTO:0002343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "tarsal" . [] oboInOwl:hasDbXref "BTO:0002343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001447 ; owl:annotatedTarget "tarsus osseus" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000077 ; owl:annotatedTarget "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001448 ; owl:annotatedTarget obo:UBERON_0003821 . [] oboInOwl:hasDbXref "Wikipedia:Metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001448 ; owl:annotatedTarget "The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes. Lacking individual names, the metatarsal bones are numbered from the medial side (side of big toe): the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the manus. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001448 ; owl:annotatedTarget "UMLS:C0025584" . [] oboInOwl:hasDbXref "BTO:0002347" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001448 ; owl:annotatedTarget "ossa metatarsalia" . [] oboInOwl:hasDbXref "BTO:0002347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001448 ; owl:annotatedTarget "ossa metatarsi" . _:genid116438 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010685, obo:UBERON_0010703 . [] oboInOwl:hasDbXref "Wikipedia:Phalanges_of_the_foot", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "A phalanx that is part of a hindlimb autopod[Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000930" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the five digits of the pes. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the pes, in a medial to lateral sequence, is 2(1)-2-3-4(3)-3(2).[AAO]" . _:genid116441 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "digital bone of pes" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006286 . [] oboInOwl:source "ncithesaurus:Foot_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "UMLS:C0584876" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "digitus pedis phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "foot digit phalanx" . [] oboInOwl:hasDbXref "MA:0000305" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "foot phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "phalanx of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "phalanx of digitus pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "phalanx of foot digit" . [] oboInOwl:hasDbXref "FMA:24493" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "phalanx of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "toe phalanx" . _:genid116451 oboInOwl:hasDbXref "FMA:24493" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "bone of toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 . [] oboInOwl:hasDbXref "AAO:0000930" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001449 ; owl:annotatedTarget "phalanges of hind digit" . (obo:UBERON_0015014 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) . [] oboInOwl:hasDbXref "PHENOSCAPE:mah", "https://github.com/obophenotype/uberon/issues/72" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "The postaxial bone of the proximal tarsals series[Phenoscape]." . [] oboInOwl:source "ncithesaurus:Calcaneum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "UMLS:C0006655" . [] oboInOwl:hasDbXref "BTO:0002355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "calcaneal bone" . [] oboInOwl:hasDbXref "MA:0001348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "calcaneum" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "calcaneus bone" . [] oboInOwl:hasDbXref "FMA:24496" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "os calcis" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "calcanei" . [] oboInOwl:hasDbXref "AAO:0000913", "ISBN:0073040584", "VSAO:0005016", "Wikipedia:Calcaneus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "fibulare" . [] oboInOwl:hasDbXref "BTO:0002355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "heel bone" . [] oboInOwl:hasDbXref "BTO:0002355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001450 ; owl:annotatedTarget "os tarsi fibulare" . [] oboInOwl:notes "numbers vary" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget _:genid116789 . [] oboInOwl:hasDbXref "MGI:llw2", "MP:0009727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "The oval-shaped tarsal bone found between the talus and the 3 cuneiform bones." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000924" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "Oval tarsal element that is located on the center of the mesopodium. It articulates with all other elements of the tarsus except tarsal 5.[AAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "connections vary depending on species. AAO: Oval tarsal element that is located on the center of the mesopodium. It articulates with all other elements of the tarsus except tarsal 5. In humans: there is a cuboid instead of distal tarsal 4 and 5 - may articulate laterally with the cuboid" . [] oboInOwl:source "ncithesaurus:Navicular_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "UMLS:C0223947" . [] oboInOwl:hasDbXref "AAO:0000924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "centrale (hind)" . [] oboInOwl:hasDbXref "FMA:24499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "navicular bone of foot" . [] oboInOwl:hasDbXref "FMA:24499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "navicular of foot" . [] oboInOwl:hasDbXref "FMA:24499", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "os naviculare" . [] oboInOwl:hasDbXref "BTO:0002356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "os naviculare pedis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000080 ; owl:annotatedTarget "A cell which moves among different tissues of the body, via blood, lymph, or other medium." . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "os tarsi centrale" . [] oboInOwl:hasDbXref "Wikipedia:Navicular_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001451 ; owl:annotatedTarget "os naviculare" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget obo:UBERON_0001454 . [] oboInOwl:hasDbXref "VSAO:0005052", "Wikipedia:Medial_cuneiform_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "Endochondral tarsal bone articulating with centralia and metatarsal 1." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000918" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "Small element that articulates with the prehallux, metatarsal I and element Y. It may be fused to tarsal 2.[AAO]" . [] oboInOwl:source "ncithesaurus:Internal_Cuneiform_Bone_of_the_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "UMLS:C1512869" . [] oboInOwl:hasDbXref "VSAO:0005052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "cuneiforme 1" . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "distal tarsal 1 bone" . [] oboInOwl:hasDbXref "VSAO:0005052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "entocuneiforme" . [] oboInOwl:hasDbXref "Wikipedia:Medial_cuneiform_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "first cuneiform" . [] oboInOwl:hasDbXref "FMA:24518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "first cuneiform bone" . [] oboInOwl:hasDbXref "FMA:24518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "medial cuneiform" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15889 ; owl:annotatedTarget "a sterol" . [] oboInOwl:hasDbXref "FMA:24518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "medial cuneiform bone" . [] oboInOwl:hasDbXref "FMA:TA", "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "os cuneiforme mediale" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "os tarsale I" . [] oboInOwl:hasDbXref "AAO:0000918" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "tarsal 1" . [] oboInOwl:hasDbXref "EMAPA:36176" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "1st cuneiform" . [] oboInOwl:hasDbXref "VSAO:0005052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "distal tarsal 1" . [] oboInOwl:hasDbXref "Wikipedia:Medial_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "os cuneiform primum" . [] oboInOwl:hasDbXref "Wikipedia:Medial_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "os cuneiforme mediale" . [] oboInOwl:hasDbXref "BTO:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "os cuneiforme primum" . [] oboInOwl:hasDbXref "BTO:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001452 ; owl:annotatedTarget "ossa cuneiforme mediale" . [] oboInOwl:hasDbXref "VSAO:0005053", "Wikipedia:Intermediate_cuneiform_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "Endochondral tarsal bone articulating with centralia and metatarsal 2." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000919" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "Small element that articulates anteriorly with metatarsal II. It may be fused to tarsal 1 or to tarsal 3.[AAO]" . [] oboInOwl:source "ncithesaurus:Middle_Cuneiform_Bone_of_the_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "UMLS:C1513292" . [] oboInOwl:hasDbXref "VSAO:0005053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "cuneiforme 2" . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "distal tarsal 2 bone" . [] oboInOwl:hasDbXref "VSAO:0005053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "mesocuneiforme" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "os cuneiforme intermedium" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "os tarsale II" . [] oboInOwl:hasDbXref "AAO:0000919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "tarsal 2" . [] oboInOwl:hasDbXref "EMAPA:36177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "2nd cuneiform" . [] oboInOwl:hasDbXref "VSAO:0005053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "distal tarsal 2" . [] oboInOwl:hasDbXref "FMA:24519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "intermediate cuneiform bone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000081 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "BTO:0002359", "Wikipedia:Intermediate_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "os cuneiforme intermedium" . [] oboInOwl:hasDbXref "BTO:0002359", "Wikipedia:Intermediate_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001453 ; owl:annotatedTarget "os cuneiforme secundum" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000081 ; owl:annotatedTarget "A cell found predominately in the blood." . [] oboInOwl:hasDbXref "VSAO:0005054", "Wikipedia:Lateral_cuneiform_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "Endochondral tarsal bone articulating with centralia and metatarsal 3." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000920" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "Small element that articulates anteriorly with metatarsal III. It may be fused to tarsal 2.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:source "http://palaeos.com/vertebrates/glossary/glossaryE.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "In some types, the cuneiform is found as two or three bones, in which case the more anterior ('dorsal' in dorsal/plantar terminology) is the ectocuneiform, while the more posterior or plantar bones are the mesocuneiform and entocuneiform.[Palaeos]" . [] oboInOwl:source "ncithesaurus:External_Cuneiform_Bone_of_the_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "UMLS:C1517036" . [] oboInOwl:hasDbXref "VSAO:0005054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "cuneiforme 3" . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "distal tarsal 3 bone" . [] oboInOwl:hasDbXref "VSAO:0005054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "ectocuneiforme" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cuneiform_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "external cuneiform" . [] oboInOwl:hasDbXref "FMA:24520" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "lateral cuneiform bone" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "os cuneiforme laterale" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "os tarsale III" . [] oboInOwl:hasDbXref "AAO:0000920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "tarsal 3" . [] oboInOwl:hasDbXref "EMAPA:36178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "3rd cuneiform" . [] oboInOwl:hasDbXref "VSAO:0005054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "distal tarsal 3" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "os cuneiforme laterale" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cuneiform_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "os cuneiforme tertium" . [] oboInOwl:hasDbXref "BTO:0002358" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001454 ; owl:annotatedTarget "ossa cuneiforme laterale" . [] oboInOwl:hasDbXref "Wikipedia:Cuboid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001455 ; owl:annotatedTarget "A tarsal bone that is formed from distal tarsals 4 and 5. [WP,modified]." . [] oboInOwl:source "ncithesaurus:Cuboid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001455 ; owl:annotatedTarget "UMLS:C0376381" . [] oboInOwl:hasDbXref "BTO:0002357", "Wikipedia:Cuboid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001455 ; owl:annotatedTarget "os cuboideum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001455 ; owl:annotatedTarget "os tarsale IV et V" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." . [] oboInOwl:source "FMA:24728" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face." . [] oboInOwl:source "HAO:0000316", "http://api.hymao.org/api/ref/67791" ; oboInOwl:taxon "NCBITaxon:7399" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "The area that extends from the median ocellus to the oral foramen[HAO]." . [] oboInOwl:source "vanat.cvm.umn.edu/TFFlectPDFs/LectFaceDevelop.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence)" . [] oboInOwl:source "ncithesaurus:Face" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "UMLS:C0015450" . [] oboInOwl:hasDbXref "Wikipedia:Face" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "facia/facies" . [] oboInOwl:hasDbXref "BTO:0003369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001456 ; owl:annotatedTarget "visage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "A zone of skin that is part of a eyelid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "EMAPA:37536" . [] oboInOwl:source "ncithesaurus:Eyelid_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "UMLS:C0222088" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "blepharon zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "eyelid zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "zone of skin of blepharon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001457 ; owl:annotatedTarget "zone of skin of eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "A zone of skin that is part of a lip [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "EMAPA:37643" . [] oboInOwl:source "ncithesaurus:Skin_of_the_Lip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "UMLS:C0222101" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "lip zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "zone of skin of lip" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001458 ; owl:annotatedTarget "skin of lips" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000082 ; owl:annotatedTarget "An epithelial cell of the lung." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "A zone of skin that is part of a external ear [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Ear_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "UMLS:C0222110" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "auricular region of head zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "auricular region zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "external ear zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "outer ear zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "zone of skin of auricular region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "zone of skin of auricular region of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "zone of skin of external ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001459 ; owl:annotatedTarget "zone of skin of outer ear" . [] oboInOwl:hasDbXref "Wikipedia:Arm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001460 ; owl:annotatedTarget "The part of the forelimb extending from the shoulder to the autopod[cjm]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000339" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001460 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Arm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001460 ; owl:annotatedTarget "brachium" . [] oboInOwl:hasDbXref "MESH:A01.378.800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001460 ; owl:annotatedTarget "upper extremity" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001461 ; owl:annotatedTarget obo:UBERON_0002529 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001461 ; owl:annotatedTarget _:genid116941 . [] oboInOwl:hasDbXref "Wikipedia:Elbow" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001461 ; owl:annotatedTarget "The elbow is the region surrounding the elbow-joint-the ginglymus or hinge joint in the middle of the arm. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna, and the inner aspect of the elbow is called the antecubital fossa. [WP,unvetted,human-specific]." . [] oboInOwl:hasDbXref "Wikipedia:Elbow" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001461 ; owl:annotatedTarget "articulatio cubiti" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget _:genid116949 . [] oboInOwl:hasDbXref "PMCID:PMC2553264", "Wikipedia:Thumb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "1st (preaxial) digit of the manus[Wikipedia]." . [] oboInOwl:hasScope "NCBITaxon:8782" ; oboInOwl:seeAlso "UBERON:0012260" ; oboInOwl:source "PMID:10220427", "PhenoscapeRCN" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." . [] oboInOwl:hasDbXref "Wikipedia:Thumb" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "digitus I" . _:genid116633 oboInOwl:hasDbXref "Wikipedia:Thumb" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "digitus primus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 . [] oboInOwl:source "ncithesaurus:Hand_Digit_1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "UMLS:C0040067" . [] oboInOwl:hasDbXref "EMAPA:17429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "digit 1 of fore-paw" . [] oboInOwl:hasDbXref "EHDAA2:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "finger 1" . [] oboInOwl:hasDbXref "AAO:0010639" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "fore digit I" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "fore limb digit 1" . [] oboInOwl:hasDbXref "MA:0000454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "hand digit 1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "manual digit I" . [] oboInOwl:hasDbXref "Wikipedia:Thumb" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "pollex" . [] oboInOwl:hasDbXref "Wikipedia:Alula" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "alula" . [] oboInOwl:hasDbXref "Wikipedia:Dewclaw" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "forelimb dewclaw" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "hand digit 1" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "thumb" . [] oboInOwl:hasDbXref "EMAPA:17429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001463 ; owl:annotatedTarget "first finger" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget _:genid116971 . [] oboInOwl:hasDbXref "Wikipedia:Hip" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000346" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.333", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "See notes for shoulder. in BTO this is part of the abdomen - this creates an inconsistency if limb and abdomen are spatially disjoint" . _:genid116652 oboInOwl:source "ncithesaurus:Hip" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "UMLS:C0019552" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002103 . [] oboInOwl:hasDbXref "FMA:24964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "hip region" . [] oboInOwl:hasDbXref "FMA:24964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "regio coxae" . [] oboInOwl:hasDbXref "Wikipedia:Hip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001464 ; owl:annotatedTarget "coxa" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001465 ; owl:annotatedTarget "A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000083 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget _:genid116986 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "A digit that is part of a pes (foot)." . [] oboInOwl:source "ncithesaurus:Toe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "UMLS:C0040357" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "digit of terminal segment of lower limb" . [] oboInOwl:hasDbXref "FMA:70664", "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "digiti pedis" . [] oboInOwl:hasDbXref "MA:0000048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "foot digit" . [] oboInOwl:hasDbXref "XAO:0003035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "hind digit" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000083 ; owl:annotatedTarget "An epithelial cell of the pancreas." . [] oboInOwl:hasDbXref "AAO:0000888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "hind_digit" . _:genid116671 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "pedal digit (phalangeal portion) plus soft tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 . [] oboInOwl:hasDbXref "FMA:25046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "toe" . [] oboInOwl:hasDbXref "Wikipedia:Toe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "digiti pedis" . [] oboInOwl:hasDbXref "BTO:0002348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001466 ; owl:annotatedTarget "digitipedis" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget _:genid117002 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget "A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000342" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.332", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget "(...) endochondral elements of the early tetrapod shoulder develop from two centers of ossification, giving rise to a scapula and a 'coracoid'.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget "In FMA, the shoulder is part of the pectoral girdle region. in MA, shoulder structures like shoulder joints, bones, nerves etc are part of the shoulder and the forelimb. E.g. humerus is a shoulder bone" . [] oboInOwl:source "ncithesaurus:Shoulder" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget "UMLS:C0037004" . [] oboInOwl:hasDbXref "Wikipedia:Shoulder" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001467 ; owl:annotatedTarget "articulatio humeri" . _:genid116685 a owl:Restriction ; owl:onClass obo:UBERON_0001075 ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:someValuesFrom obo:UBERON_0000915 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget obo:UBERON_0002216 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget _:genid117014 . [] oboInOwl:notes "connects successive pairs of centra" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget _:genid117016 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=87401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "FMA has 'intervertebral joint' as a GAT, and has two distinct classes 'intervertebral symphysis' and 'intervertebral syndesmosis', but note that the latter do not connect the centra" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "EMAPA:37622" . [] oboInOwl:source "ncithesaurus:Vertebral_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "UMLS:C1182940" . [] oboInOwl:hasDbXref "FMA:25511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "intervertebral symphysis" . [] oboInOwl:hasDbXref "FMA:25511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001468 ; owl:annotatedTarget "joint of vertebral body" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget obo:UBERON_0011108 . [] oboInOwl:notes "clavicular notch of the manubrium sterni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget _:genid117031 . [] oboInOwl:notes "sternal end of the clavicle and first rib" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget _:genid117033 . [] oboInOwl:hasDbXref "Wikipedia:Sternoclavicular_articulation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget "The sternoclavicular articulation is a double arthrodial joint composed of two portions separated by an articular disc. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib, visible from the outside as the suprasternal notch. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, which is considerably thicker than that on the latter bone. The ligaments of this joint are: Articular capsule Anterior sternoclavicular ligament Posterior sternoclavicular ligament Interclavicular ligament Costoclavicular ligament Articular disk [WP,unvetted]." . [] oboInOwl:hasDbXref "Wikipedia:Sternoclavicular_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget "sternoclavicular" . [] oboInOwl:source "ncithesaurus:Sternoclavicular_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget "UMLS:C0038291" . [] oboInOwl:hasDbXref "Wikipedia:Sternoclavicular_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget "sternoclavicular articulation" . [] oboInOwl:hasDbXref "Wikipedia:Sternoclavicular_articulation" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001469 ; owl:annotatedTarget "articulatio sternoclavicularis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget obo:UBERON_0011139 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget _:genid117047 . [] oboInOwl:hasDbXref "Wikipedia:Glenohumeral_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "The glenohumeral joint, commonly known as the shoulder joint, is a multiaxial synovial ball and socket joint and involves articulation between the glenoid fossa of the scapula (shoulder blade) and the head of the humerus (upper arm bone). [WP,unvetted]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "in FMA, this is part of the bony pectoral girdle, alongside the skeleton of pectoral girdle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "joint of shoulder" . [] oboInOwl:hasDbXref "MA:0000459" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "shoulder joint" . [] oboInOwl:source "ncithesaurus:Shoulder_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "UMLS:C0037009" . [] oboInOwl:hasDbXref "FMA:25912", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "articulatio humeri" . [] oboInOwl:hasDbXref "FMA:25912" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "humeral joint" . [] oboInOwl:hasDbXref "Wikipedia:Glenohumeral_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001470 ; owl:annotatedTarget "humeroscapular joint" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000084 ; owl:annotatedTarget obo:CL_0000542 . [] oboInOwl:hasDbXref "MP:0003553", "NCBI:matt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001471 ; owl:annotatedTarget "The loose fold of skin that covers the penis." . [] oboInOwl:hasDbXref "Wikipedia:Vaginal_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001472 ; owl:annotatedTarget "The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001472 ; owl:annotatedTarget "EMAPA:37801" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000084 ; owl:annotatedTarget "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." . [] oboInOwl:hasDbXref "Wikipedia:Vaginal_venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001472 ; owl:annotatedTarget "plexus venosus vaginalis" . [] oboInOwl:hasDbXref "BTO:0000752", "Wikipedia:Lymphatic_vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005105" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011005" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "A vessel that contains or conveys lymph.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001249" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Lymphatic_Vessel" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "UMLS:C0229889" . [] oboInOwl:hasDbXref "Wikipedia:Lymphatic_vessel" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001473 ; owl:annotatedTarget "vas lymphaticum" . [] oboInOwl:source "VSAO-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget _:genid117090 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000057", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "Skeletal element that is composed of bone tissue." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000047" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001514" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000057" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "Skeletal element that is composed of bone tissue.[VSAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000047" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001190" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1159/000324245 Murdock DJ, Donoghue PC, Evolutionary Origins of Animal Skeletal Biomineralization. Cells Tissues Organs (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]" . [] oboInOwl:source "ncithesaurus:Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "UMLS:C0262950" . [] oboInOwl:hasDbXref "FMA:5018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "bone organ" . [] oboInOwl:hasDbXref "AEO:0000082", "BTO:0000140", "MA:0001459", "VHOG:0001190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "bone" . [] oboInOwl:hasDbXref "ZFA:0001514" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001474 ; owl:annotatedTarget "bones" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget obo:UBERON_0001482 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117111 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117113 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117115 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117117 . [] oboInOwl:notes "the anterior border and upper surface of the lateral third of the clavicle acromion spine of the scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117119 . [] oboInOwl:notes "the anterior border and upper surface of the lateral third of the clavicle acromion spine of the scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117121 . [] oboInOwl:notes "the anterior border and upper surface of the lateral third of the clavicle acromion spine of the scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117123 . [] oboInOwl:notes "deltoid tuberosity of humerus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117125 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117127 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget _:genid117129 . _:genid116789 oboInOwl:hasDbXref "FMA:32521", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "A muscle of shoulder which attaches to the scapula, clavicle and humerus.[FMA,generalized]." ; owl:onProperty core:distally_connected_to ; owl:someValuesFrom obo:UBERON_0010721 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010716" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:MEJ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus.[AAO]" . [] oboInOwl:source "ncithesaurus:Deltoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "UMLS:C0224234" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "deltoid muscle" . [] oboInOwl:hasDbXref "AAO:0010716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "m. deltoideus" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "musculus deltoideus" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "common shoulder muscle" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "deltoideus" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "deltoideus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001476 ; owl:annotatedTarget "musculus deltoideus" . [] oboInOwl:source "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001479 ; owl:annotatedTarget obo:UBERON_0013630 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001479 ; owl:annotatedTarget "A sesamoid element that is composed of bone tissue." . [] oboInOwl:source "ncithesaurus:Sesamoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001479 ; owl:annotatedTarget "UMLS:C0036846" . [] oboInOwl:hasDbXref "Wikipedia:Sesamoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001479 ; owl:annotatedTarget "ossa sesamoidea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001480 ; owl:annotatedTarget "A carpal bone that proximally_connected_to a forelimb zeugopod skeleton." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001481 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001481 ; owl:annotatedTarget "A distal carpal endochondral element that is composed primarily of a bone tissue." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000847" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001481 ; owl:annotatedTarget "Series of elements that articulate with the metacarpals.[AAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001481 ; owl:annotatedTarget "Primitively, each of the distal bones appears to have articulated with a single metacarpal" . [] oboInOwl:hasDbXref "AAO:0000847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001481 ; owl:annotatedTarget "distal carpal" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001482 ; owl:annotatedTarget _:genid117172 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001482 ; owl:annotatedTarget "Any muscle organ that is part of a shoulder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001482 ; owl:annotatedTarget "muscle organ of shoulder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001482 ; owl:annotatedTarget "shoulder muscle organ" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001483 ; owl:annotatedTarget "A zone of skin that is part of a shoulder region." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001483 ; owl:annotatedTarget "in MA this is a subclass of forelimb skin, but this violates part-disjointness in Uberon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001483 ; owl:annotatedTarget "shoulder zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001483 ; owl:annotatedTarget "zone of skin of shoulder" . [] oboInOwl:hasDbXref "Wikipedia:Articular_capsule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "check ncita" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "EMAPA:37621" . [] oboInOwl:source "ncithesaurus:Joint_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "UMLS:C0206207" . [] oboInOwl:hasDbXref "FMA:34836", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "capsula articularis" . [] oboInOwl:hasDbXref "Wikipedia:Articular_capsule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001484 ; owl:annotatedTarget "capsulae articulares" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001485 ; owl:annotatedTarget _:genid117207 . [] oboInOwl:hasDbXref "Wikipedia:Knee" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001485 ; owl:annotatedTarget "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Knee_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001485 ; owl:annotatedTarget "UMLS:C0022745" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001485 ; owl:annotatedTarget "joint of knee" . [] oboInOwl:hasDbXref "Wikipedia:Knee" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001485 ; owl:annotatedTarget "articulatio genus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget obo:UBERON_0011107 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget _:genid117220 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget _:genid117222 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget "A synovial joint that connects the femur to the acetbulum of the innominate bone." . [] oboInOwl:source "ncithesaurus:Hip_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget "UMLS:C0019558" . [] oboInOwl:hasDbXref "FMA:35178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget "articulatio coxofemoralis" . [] oboInOwl:hasDbXref "Wikipedia:Hip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001486 ; owl:annotatedTarget "coxal articulation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001487 ; owl:annotatedTarget "A skeletal joint that is part of a pes [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71349", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001487 ; owl:annotatedTarget "articulationes pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001487 ; owl:annotatedTarget "hind limb autopod joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001487 ; owl:annotatedTarget "joint of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "FMA:71349" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001487 ; owl:annotatedTarget "joints of foot" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.062", "Wikipedia:Ankle", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "A joint that connects the hindlimb autopod and zeugopod skeletons." . [] oboInOwl:source "ncithesaurus:Ankle_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "UMLS:C0003087" . [] oboInOwl:hasDbXref "Wikipedia:Hock_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "gambrel" . [] oboInOwl:hasDbXref "Wikipedia:Hock_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "hock" . [] oboInOwl:hasDbXref "Wikipedia:Hock_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "hock joint" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "talotibial joint" . [] oboInOwl:hasDbXref "BTO:0004706" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "mortise joint" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "talocrural articulation" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001488 ; owl:annotatedTarget "talocrural joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001489 ; owl:annotatedTarget "A skeletal joint that is part of a manus (hand) [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71345", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001489 ; owl:annotatedTarget "articulationes manus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001489 ; owl:annotatedTarget "joint of terminal segment of free upper limb" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget _:genid117271 . [] oboInOwl:hasDbXref "Wikipedia:Elbow", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "A joint that connects the forelimb zeugopod and stylopod skeletons[Obol]." . [] oboInOwl:source "HP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "In human anatomy, the elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis" . [] oboInOwl:source "ncithesaurus:Elbow_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "UMLS:C0013770" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "articulatio cubiti" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "cubital region joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "joint of cubital region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001490 ; owl:annotatedTarget "joint of elbow" . [] oboInOwl:hasDbXref "Wikipedia:Wrist", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/?group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "A joint connecting the forelimb zeugopod skeleton with the carpal skeleton." . _:genid116941 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "in FMA this includes radio-carpal and radio-ulnar *ligaments*" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 . [] oboInOwl:source "ncithesaurus:Wrist_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "UMLS:C1322271" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "carpal region joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "joint of carpal region" . [] oboInOwl:hasDbXref "FMA:35291" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001491 ; owl:annotatedTarget "radiocarpal joint" . _:genid116949 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0004487, obo:UBERON_0012141 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000094 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "Wikipedia:Radial_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001492 ; owl:annotatedTarget "A nerve that supplies the upper limb, including the triceps brachii muscle of the arm, as well as all 12 muscles in the posterior osteofascial compartment of the forearm, as well as the associated joints and overlying skin." . [] oboInOwl:source "ncithesaurus:Radial_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001492 ; owl:annotatedTarget "UMLS:C0034518" . [] oboInOwl:hasDbXref "Wikipedia:Radial_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001492 ; owl:annotatedTarget "nervus radialis" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget _:genid117301 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget _:genid117303 . [] oboInOwl:hasDbXref "Wikipedia:Axillary_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget "The axillary nerve is a nerve of the human body, that comes off the posterior cord of the brachial plexus at the level of the axilla (armpit) and carries nerve fibers from C5 and C6. The axillary nerve travels through the quadrangular space with the posterior circumflex humeral artery and vein. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Axillary_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget "UMLS:C0228885" . [] oboInOwl:hasDbXref "Wikipedia:Axillary_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget "auxillery nerve" . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000094 ; owl:annotatedTarget "A leukocyte with abundant granules in the cytoplasm." . [] oboInOwl:hasDbXref "Wikipedia:Axillary_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget "circumflex nerve" . [] oboInOwl:hasDbXref "Wikipedia:Axillary_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001493 ; owl:annotatedTarget "nervus axillaris" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget obo:UBERON_0008196 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget _:genid117312 . [] oboInOwl:hasDbXref "ncithesaurus:Pectoralis_Muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010727" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:MEJ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus.[AAO]" . [] oboInOwl:source "ncithesaurus:Pectoralis_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "UMLS:C0030747" . [] oboInOwl:hasDbXref "AAO:0010727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "M. pectoralis" . [] oboInOwl:hasDbXref "FMA:37349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "muscle of pectoral part of chest" . [] oboInOwl:hasDbXref "FMA:37349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "muscle of pectoral region" . _:genid116971 oboInOwl:hasDbXref "BTO:0000023" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "breast muscle" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001271 . [] oboInOwl:hasDbXref "BTO:0000023" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001495 ; owl:annotatedTarget "pectoralis muscle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget _:genid117324 . [] oboInOwl:hasDbXref "GO:0035905", "Wikipedia:Ascending_aorta" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." . [] oboInOwl:source "ncithesaurus:Ascending_Aorta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget "UMLS:C0003956" . [] oboInOwl:hasDbXref "EMAPA:17014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget "ascending thoracic aorta" . [] oboInOwl:hasDbXref "Wikipedia:Ascending_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget "aorta ascendens" . [] oboInOwl:hasDbXref "Wikipedia:Ascending_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001496 ; owl:annotatedTarget "pars ascendens aortae" . ( ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget _:genid117338 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "Any muscle organ that is part of a pelvic girdle [Automatically generated definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "Note that in MA, this is a subclass of pelvis muscle; in FMA this is a hindlimb muscle, but recall in FMA hindlimb includes the girdle." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "girdle-pelvic muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "muscle organ of girdle-pelvic" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "muscle organ of pelvic girdle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "muscle organ of pelvic girdle bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "pelvic girdle muscle organ" . [] oboInOwl:hasDbXref "EMAPA:18185" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001497 ; owl:annotatedTarget "pelvic girdle skeletal muscle" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001498 ; owl:annotatedTarget _:genid117353 . _:genid117002 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001498 ; owl:annotatedTarget "Any muscle organ that is part of a pes [Automatically generated definition]." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001421 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001498 ; owl:annotatedTarget "foot muscle organ" . [] oboInOwl:hasDbXref "FMA:37369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001498 ; owl:annotatedTarget "muscle of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001498 ; owl:annotatedTarget "muscle organ of foot" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget _:genid117363 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "A muscle organ that is part of an arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "MA:0000594" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "arm muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "arm skeletal muscle" . _:genid117014 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "arm skeletal muscle tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "muscle of upper arm or lower arm" . _:genid117016 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "upper arm / lower arm muscle" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001075 . [] oboInOwl:hasDbXref "EHDAA2:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001499 ; owl:annotatedTarget "arm muscle system" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget _:genid117377 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget "Any muscle organ that is part of a manus [Automatically generated definition]." . [] oboInOwl:hasDbXref "MA:0000628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget "hand muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget "manus muscle organ" . [] oboInOwl:hasDbXref "FMA:37372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget "muscle of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001500 ; owl:annotatedTarget "muscle organ of manus" . _:genid117031 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000975, obo:UBERON_0002398 . _:genid117033 a owl:Restriction ; owl:onProperty obo:RO_0002176, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001105, obo:UBERON_0002374 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget obo:UBERON_0014375 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget "Any of the interosseous muscles of the manus (hand). This includes the dorsal and plantar interossei." . [] oboInOwl:source "MURDOCH:1022" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget "The interosseous muscles are flexor muscles of the manus that help support and flex the metacarpophalangeal joints. In some species the muscles are known as the suspensory ligaments. The muscles are found under the deep digital flexor tendon and originate from the base of each metacarpal bone. From its origin each muscle runs a short way down until it divides into two tendons that continue down and insert onto the base of its corresponding proximal phalanx. Each tendon has a sesamoid imbedded within it, that lie over the metacarpophalangeal joint. A small tendon, sometimes known as an extensor branch, continues to proceed from the base of each proximal phalanx and connects to the common extensor tendon. It has a small role to play in the extension of each phalanx. The main innervation of this muscle is via a branch of the ulnaris nerve[MURDOCH:1022]." . [] oboInOwl:source "ncithesaurus:Hand_Interosseous_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget "UMLS:C0224295" . [] oboInOwl:hasDbXref "MA:0002313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget "hand interosseous muscle" . [] oboInOwl:hasDbXref "FMA:37417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001502 ; owl:annotatedTarget "interosseous muscle of hand" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget _:genid117396 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget _:genid117398 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_interossei_muscles_(hand)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "The dorsal interossei of the hand are muscles that occupy the space between the metacarpals. There are four dorsal interossei in each hand. They are specified as 'dorsal' to contrast them with the palmar interossei, which are located on the anterior side of the metacarpals. The dorsal interosseous muscles are bipennate, with each muscle arising by two heads from the adjacent sides of the metacarpal bones, but more extensively from the metacarpal bone of the finger into which the muscle is inserted. They are inserted into the bases of the proximal phalanges and into the extensor expansion of the corresponding extensor digitorum tendon. The middle digit has two dorsal interossei insert onto it while the first digit (thumb) and the fifth digit (little finger) have none[WP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "EMAPA:37519" . [] oboInOwl:source "ncithesaurus:Dorsal_Hand_Interosseous_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "UMLS:C1744530" . [] oboInOwl:hasDbXref "MA:0002314" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "dorsal hand interosseus muscle" . _:genid117047 oboInOwl:hasDbXref "FMA:37418" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "dorsal interosseous of hand" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 . [] oboInOwl:hasDbXref "FMA:37418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001503 ; owl:annotatedTarget "dorsal interosseous muscle of hand" . [] oboInOwl:notes "Musculocutaneous nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget _:genid117407 . [] oboInOwl:notes "short head: coracoid process of the scapula. long head: supraglenoid tubercle" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget _:genid117409 . [] oboInOwl:notes "short head: coracoid process of the scapula. long head: supraglenoid tubercle" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget _:genid117411 . [] oboInOwl:notes "radial tuberosity and bicipittal aponeurosis into deep fascia on medial part of forearm" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget _:genid117413 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget _:genid117415 . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "A muscle in the forelimb stylopod which in humans has several functions, the most important being to rotate the forearm and to flex the elbow. [WP,unvetted]." . [] oboInOwl:hasDbXref "EHDAA2:0000167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "biceps" . [] oboInOwl:source "ncithesaurus:Biceps" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "UMLS:C0559499" . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "biceps brachii %26 brachialis muscles" . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "biceps brachii muscle" . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "biceps cubiti" . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "biceps muscle" . [] oboInOwl:hasDbXref "Wikipedia:Biceps_brachii_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001507 ; owl:annotatedTarget "musculus biceps brachii" . [] oboInOwl:notes "left arch 4 in human" ; oboInOwl:source "embryology.ch" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget _:genid117427 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0004113" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001196" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/arch+of+aorta" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001196" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460 and p.461 Figure 12.20", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:3768", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "arcus aortae" . [] oboInOwl:hasDbXref "FMA:3768" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "aortic arch" . [] oboInOwl:hasDbXref "GAID:471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001508 ; owl:annotatedTarget "thoracic aorta" . [] oboInOwl:source "OG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117438 . [] oboInOwl:notes "radial nerve and axillary nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117440 . [] oboInOwl:notes "radial nerve and axillary nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117442 . [] oboInOwl:notes "lateral head: posterior humerus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117444 . [] oboInOwl:notes "long head: infraglenoid tubercle of scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117446 . [] oboInOwl:notes "olecranon process of ulna" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117448 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget _:genid117450 . [] oboInOwl:hasDbXref "Wikipedia:Triceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "The triceps brachii muscle (Latin for 'three-headed' muscle of the arm, it is called a three headed muscle because there are three bundles of muscle, each of different origin, joining together at the elbow) is the large muscle on the back of the human upper limb. It is the muscle principally responsible for extension of the elbow joint (i.e. straightening of the arm). Though a similarly-named muscle, the triceps surae, is found on the lower leg, the triceps brachii is commonly called simply the 'triceps'. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Triceps_Brachii" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "UMLS:C0559502" . [] oboInOwl:hasDbXref "EHDAA2:0002080" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "triceps" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "triceps brachii muscle" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_brachii_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "musculus triceps brachii" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_brachii_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001509 ; owl:annotatedTarget "triceps muscle" . _:genid117090 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001465, obo:UBERON_0002481 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001510 ; owl:annotatedTarget "A zone of skin that is part of a knee [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Knee_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001510 ; owl:annotatedTarget "UMLS:C0222275" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001510 ; owl:annotatedTarget "knee zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001510 ; owl:annotatedTarget "zone of skin of knee" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001511 ; owl:annotatedTarget "A zone of skin that is part of a leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001511 ; owl:annotatedTarget "EMAPA:37352" . [] oboInOwl:source "ncithesaurus:Leg_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001511 ; owl:annotatedTarget "UMLS:C0222279" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001511 ; owl:annotatedTarget "leg zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001511 ; owl:annotatedTarget "zone of skin of leg" . _:genid117111 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "A zone of skin that is part of an ankle [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008713 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "EMAPA:37353" . _:genid117113 oboInOwl:source "ncithesaurus:Ankle_Skin" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "UMLS:C0222286" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001493 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "ankle zone of skin" . _:genid117115 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "tarsal region skin" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006219 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001512 ; owl:annotatedTarget "zone of skin of ankle" . _:genid117117 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000014 _:genid117119 ) ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002498 . _:genid117119 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001105, obo:UBERON_0002387 . _:genid117121 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002387, obo:UBERON_0002497 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001513 ; owl:annotatedTarget obo:UBERON_0003532 . _:genid117123 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001513 ; owl:annotatedTarget "A zone of skin that is part of a pes [Automatically generated definition]." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006849 . [] oboInOwl:source "ncithesaurus:Foot_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001513 ; owl:annotatedTarget "UMLS:C0222289" . _:genid117125 oboInOwl:hasDbXref "FMA:37834" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001513 ; owl:annotatedTarget "skin of foot" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002498 . [] oboInOwl:hasDbXref "EMAPA:18504" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001513 ; owl:annotatedTarget "skin of hind-paw" . _:genid117127 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001009, obo:UBERON_0002036 . _:genid117129 a owl:Restriction ; owl:onProperty obo:RO_0002254, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001112, obo:UBERON_0005613 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget obo:UBERON_0005800 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget _:genid117498 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget _:genid117502 . [] oboInOwl:hasDbXref "GO:0035906", "Wikipedia:Descending_aorta" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Descending_Aorta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget "UMLS:C0011666" . [] oboInOwl:hasDbXref "FMA:3784" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget "pars descendens aortae" . [] oboInOwl:hasDbXref "Wikipedia:Descending_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget "aorta descendens" . [] oboInOwl:hasDbXref "Wikipedia:Descending_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001514 ; owl:annotatedTarget "pars descendens aortae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget obo:UBERON_0005800 . [] oboInOwl:hasDbXref "MP:0010468", "http://www.medterms.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." . [] oboInOwl:source "ncithesaurus:Thoracic_Aorta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget "UMLS:C1522460" . [] oboInOwl:hasDbXref "FMA:3786", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget "aorta thoracica" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget "aorta thoracalis" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001515 ; owl:annotatedTarget "pars thoracica aortae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget _:genid117522 . [] oboInOwl:hasDbXref "BTO:0002976", "Wikipedia:Abdominal_aorta" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Abdominal_Aorta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "UMLS:C0003484" . [] oboInOwl:hasDbXref "FMA:3789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "abdominal part of aorta" . [] oboInOwl:hasDbXref "FMA:3789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "descending abdominal aorta" . [] oboInOwl:hasDbXref "FMA:3789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "pars abdominalis aortae" . [] oboInOwl:hasDbXref "BTO:0002976" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "abdominal part of aorta" . [] oboInOwl:hasDbXref "BTO:0002976", "Wikipedia:Abdominal_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "aorta abdominalis" . [] oboInOwl:hasDbXref "BTO:0002976", "Wikipedia:Abdominal_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001516 ; owl:annotatedTarget "pars abdominalis aortae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "A zone of skin that is part of a elbow [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Elbow_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "UMLS:C0222213" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "cubital region zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "elbow zone of skin" . _:genid117172 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "zone of skin of cubital region" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004476 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001517 ; owl:annotatedTarget "zone of skin of elbow" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "A zone of skin that is part of a wrist [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "EMAPA:37351" . [] oboInOwl:source "ncithesaurus:Wrist_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "UMLS:C0222223" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "carpal region zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "wrist zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "zone of skin of carpal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001518 ; owl:annotatedTarget "zone of skin of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001519 ; owl:annotatedTarget "A zone of skin that is part of a manus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001519 ; owl:annotatedTarget "UMLS:C0222224" . [] oboInOwl:hasDbXref "MA:0000630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001519 ; owl:annotatedTarget "hand skin" . [] oboInOwl:hasDbXref "FMA:38295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001519 ; owl:annotatedTarget "skin of hand" . [] oboInOwl:hasDbXref "EMAPA:18486" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001519 ; owl:annotatedTarget "skin of fore-paw" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001528 ; owl:annotatedTarget obo:UBERON_0011139 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001528 ; owl:annotatedTarget "A joint that connects the radius and the ulna. Examples: proximal and distal radio-ulnar joints." . [] oboInOwl:hasDbXref "FMA:38863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001528 ; owl:annotatedTarget "radioulnar joint" . _:genid117207 a owl:Restriction ; owl:onProperty obo:RO_0002202, core:channels_from ; owl:someValuesFrom obo:UBERON_0001508, obo:UBERON_0006256 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010663" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "innominate" . [] oboInOwl:source "ncithesaurus:Innominate_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "UMLS:C0006094" . [] oboInOwl:hasDbXref "MA:0001922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "brachiocephalic trunk" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "innominate artery" . [] oboInOwl:hasDbXref "FMA:3932", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "truncus brachiocephalicus" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001529 ; owl:annotatedTarget "truncus brachiocephalicus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget obo:UBERON_0004573 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget _:genid117590 . [] oboInOwl:hasDbXref "Wikipedia:Common_carotid_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." . _:genid117220 oboInOwl:hasDbXref "FMA:3939" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "carotid artery" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001464 . [] oboInOwl:source "ncithesaurus:Common_Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "UMLS:C0162859" . _:genid117222 oboInOwl:hasDbXref "EHDAA2:0000217" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "carotid artery system" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006244 . [] oboInOwl:hasDbXref "FMA:3939" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "common carotid artery" . [] oboInOwl:hasDbXref "FMA:3939" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "trunk of common carotid tree" . [] oboInOwl:hasDbXref "Wikipedia:Common_carotid_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001530 ; owl:annotatedTarget "a. carotis communis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget obo:UBERON_0001530 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget "The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk." . [] oboInOwl:source "ncithesaurus:Right_Common_Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget "UMLS:C0226086" . [] oboInOwl:hasDbXref "MA:0001928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget "right common carotid artery" . [] oboInOwl:hasDbXref "FMA:3941" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget "trunk of right common carotid tree" . [] oboInOwl:hasDbXref "FMA:3941" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001531 ; owl:annotatedTarget "right common carotid artery" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget obo:UBERON_0005396 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget _:genid117611 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget _:genid117613 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget _:genid117615 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000267" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Internal+carotid+artery" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "Each of two arteries starting at the bifurcation of the common carotid arteries through which blood circulates to many structures and organs in the head. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011054" ; oboInOwl:ontology "AAO" ; oboInOwl:source "PMID:12606281" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "One of the major arteries of the head, it is the as the cranial continuation of the aortic arches and the dorsal aorta. It curves ventrally before resuming a dorsal course as it enters the head proper, and it lies ventral to the internal jugular vein. The internal carotid artery gives off palatine, ophthalmic, and cerebral branches by stage NF stage 41.[AAO]" . [] oboInOwl:source "ncithesaurus:Internal_Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "UMLS:C0007276" . [] oboInOwl:hasDbXref "ZFA:0005081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "cranial carotid artery" . [] oboInOwl:hasDbXref "AAO:0010219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "internal carotid" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "ICA" . [] oboInOwl:hasDbXref "Wikipedia:Internal_carotid_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001532 ; owl:annotatedTarget "arteria carotis interna" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget _:genid117628 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget _:genid117630 . [] oboInOwl:hasDbXref "ISBN:0073040584", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010232" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO]" . [] oboInOwl:source "Wikipedia:Subclavian_artery" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005086" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO]" . [] oboInOwl:source "ncithesaurus:Subclavian_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "UMLS:C0038530" . [] oboInOwl:hasDbXref "XAO:0000365" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "arteria subclavia" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "PA" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:068340007X", "MESH:D008407", "PMCID:PMC1312421", "PMCID:PMC2855166", "PMID:15153310", "PMID:16455980", "PMID:19671378", "PMID:212366338", "PMID:9354811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." . [] oboInOwl:hasDbXref "Wikipedia:Subclavian_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001533 ; owl:annotatedTarget "arteria subclavia" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001534 ; owl:annotatedTarget "The subclavian artery that supplies the right pectoral appendage." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001534 ; owl:annotatedTarget "EMAPA:37384" . [] oboInOwl:source "ncithesaurus:Right_Subclavian_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001534 ; owl:annotatedTarget "UMLS:C0226261" . [] oboInOwl:hasDbXref "FMA:3953", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001534 ; owl:annotatedTarget "arteria subclavia dextra" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "labrocyte" . _:genid117271 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001533, obo:UBERON_0006224 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0011513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001535 ; owl:annotatedTarget "The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck." . [] oboInOwl:source "ncithesaurus:Vertebral_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001535 ; owl:annotatedTarget "UMLS:C0042559" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001535 ; owl:annotatedTarget "arteria vertebralis" . [] oboInOwl:hasDbXref "ZFA:0005033" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001535 ; owl:annotatedTarget "vertebral arteries" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget obo:UBERON_0001530 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget "The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax." . [] oboInOwl:source "ncithesaurus:Left_Common_Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget "UMLS:C0226087" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "mastocyte" . [] oboInOwl:hasDbXref "MA:0001927" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget "left common carotid artery" . [] oboInOwl:hasDbXref "FMA:4058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget "trunk of left common carotid tree" . [] oboInOwl:hasDbXref "FMA:4058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001536 ; owl:annotatedTarget "left common carotid artery" . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget obo:UBERON_0003968 . [] oboInOwl:hasDbXref "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000097 ; owl:annotatedTarget "tissue basophil" . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002352", "Wikipedia:Popliteal_lymph_node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "The lymph nodes which drain the legs; contained in the popliteal fossa." . [] oboInOwl:source "PMID:16624319" ; oboInOwl:taxon "NCBITaxon:10090" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "In the popliteal fossa between biceps femoris m. and semitendinosus m.." . [] oboInOwl:source "ncithesaurus:Popliteal_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "UMLS:C0588057" . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_lymph_nodes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "popliteal glands" . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_lymph_nodes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "popliteal lymph glands" . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_lymph_nodes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001543 ; owl:annotatedTarget "popliteal lymph node" . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001544 ; owl:annotatedTarget _:genid117676 . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001544 ; owl:annotatedTarget "The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001544 ; owl:annotatedTarget "EMAPA:37181" . [] oboInOwl:source "ncithesaurus:Popliteal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001544 ; owl:annotatedTarget "UMLS:C0032652" . _:genid117301 oboInOwl:hasDbXref "Wikipedia:Popliteal_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001544 ; owl:annotatedTarget "vena poplitea" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget obo:UBERON_0010370 . _:genid117303 oboInOwl:source "FMA/obol" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget _:genid117683 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001814 . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget _:genid117685 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget obo:UBERON_0001546 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tibial_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget "A vein of the lower limb that carries blood from the anterior compartment of the leg to the popliteal vein which is forms when it joins with the posterior tibial vein. Like most deep veins, the anterior tibial vein is accompanied by an artery of the same name, the anterior tibial artery, along its course. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget "EMAPA:37135" . [] oboInOwl:source "ncithesaurus:Anterior_Tibial_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget "UMLS:C0226833" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tibial_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001545 ; owl:annotatedTarget "venae tibiales anteriores" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget obo:UBERON_0010370 . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget _:genid117693 . _:genid117312 oboInOwl:source "FMA/obol" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget _:genid117695 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004464 . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tibial_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget "A vein of the lower limb carries blood from the posterior compartment and plantar surface of the foot to the popliteal vein which it forms when it joins with the anterior tibial vein. Like most deep veins, the posterior tibial vein is accompanied by an artery of the same name, the posterior tibial artery, along its course. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget "EMAPA:37183" . [] oboInOwl:source "ncithesaurus:Posterior_Tibial_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget "UMLS:C0226832" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tibial_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001546 ; owl:annotatedTarget "venae tibiales posteriores" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001547 ; owl:annotatedTarget _:genid117701 . [] oboInOwl:hasDbXref "Wikipedia:Small_saphenous_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001547 ; owl:annotatedTarget "The small saphenous vein (also lesser saphenous vein), is a relatively large vein of the superficial posterior leg. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001547 ; owl:annotatedTarget "EMAPA:37187" . [] oboInOwl:source "ncithesaurus:Short_Saphenous_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001547 ; owl:annotatedTarget "UMLS:C0226827" . [] oboInOwl:hasDbXref "Wikipedia:Small_saphenous_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001547 ; owl:annotatedTarget "vena saphena parva" . _:genid117324 a owl:Restriction ; owl:onProperty obo:RO_0002179, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000983, obo:UBERON_0005338 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_metatarsal_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001549 ; owl:annotatedTarget "The dorsal metatarsal veins are veins which drain the metatarsus of the foot. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001549 ; owl:annotatedTarget "EMAPA:37143" . [] oboInOwl:source "ncithesaurus:Dorsal_Metatarsal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001549 ; owl:annotatedTarget "UMLS:C0835053" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_metatarsal_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001549 ; owl:annotatedTarget "venae metatarsales dorsales" . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001550 ; owl:annotatedTarget _:genid117716 . [] oboInOwl:hasDbXref "Wikipedia:Medial_marginal_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001550 ; owl:annotatedTarget "A continuation of the Dorsal venous arch of the foot and is the origin of the long saphenous vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001550 ; owl:annotatedTarget "EMAPA:37170" . [] oboInOwl:hasDbXref "FMA:44420", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001550 ; owl:annotatedTarget "vena marginalis medialis pedis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001551 ; owl:annotatedTarget _:genid117723 . _:genid117338 oboInOwl:source "http://www.veinsurg.com/fr/biblio/echodoppler/echodoppler_11.php" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0001551 ; owl:annotatedTarget "The term 'sural veins' is not sufficient to appropriately designate the complex venous system of the calf. This should be designated as soleal veins (venae solealis), the veins of the soleus muscle and gastrocnemius veins (venae gastrocnemii)" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004470 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001551 ; owl:annotatedTarget "EMAPA:37231" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000098 ; owl:annotatedTarget "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." . [] oboInOwl:hasDbXref "FMA:44561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001551 ; owl:annotatedTarget "sural vein" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001552 ; owl:annotatedTarget _:genid117728 . [] oboInOwl:hasDbXref "MP:0011315", "Wikipedia:Arcuate_artery_of_the_foot" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001552 ; owl:annotatedTarget "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." . [] oboInOwl:hasDbXref "MA:0002583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001552 ; owl:annotatedTarget "arcuate artery" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D007395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000099 ; owl:annotatedTarget "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "A zone of skin that is part of a hip region." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "in MA this isa hindlimb skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "hip region zone of skin" . _:genid117353 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "hip zone of skin" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004488 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "regio coxae zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "zone of skin of hip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "zone of skin of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001554 ; owl:annotatedTarget "zone of skin of regio coxae" . [] oboInOwl:hasDbXref "MESH:D009046", "PMID:16875686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000100 ; owl:annotatedTarget "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." . [] oboInOwl:source "NCBIBook:NBK10107" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget _:genid117748 . [] oboInOwl:hasDbXref "Wikipedia:Talk:Human_gastrointestinal_tract", "https://github.com/geneontology/go-ontology/issues/7549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "A tube extending from the mouth to the anus." . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget obo:NCBITaxon_147099 . _:genid117363 oboInOwl:source "DOI:10.1371/journal.pone.0016309" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget obo:NCBITaxon_41324 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004474 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000112" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "The alimentary or digestive tract, and associated organs.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000309" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "FMA also has a term 'gastrointestinal tract', but this includes the liver." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509" . [] oboInOwl:source "ncithesaurus:Gastrointestinal_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "UMLS:C0017189" . [] oboInOwl:hasDbXref "ZFA:0000112" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "enteric tract" . [] oboInOwl:hasDbXref "BTO:0000058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001555 ; owl:annotatedTarget "digestive canal" . [] oboInOwl:hasDbXref "FMA:45659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001556 ; owl:annotatedTarget "Subdivision of urinary system which consists of the urinary bladder and the urethra." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001557 ; owl:annotatedTarget "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." . _:genid117377 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001557 ; owl:annotatedTarget "Some specify that the glottis (vocal cords) is the defining line between the upper and lower respiratory tracts;[2] yet even others make the line at the cricoid cartilage. The FMA includes nose, nasopharynx, oropharynx and larynx[WP]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004489 . [] oboInOwl:hasDbXref "Wikipedia:Lower_respiratory_tract", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001558 ; owl:annotatedTarget "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001560 ; owl:annotatedTarget obo:UBERON_0034944 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget obo:UBERON_0008571 . [] oboInOwl:notes "anterior belly - mandibular division of the trigeminal via the mylohyoid nerve; posterior belly - facial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget _:genid117771 . [] oboInOwl:exception "Orangutan DOI:10.1007/BF02547558" ; oboInOwl:notes "Intermediate tendon" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget _:genid117773 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "A group of muscles (or in some classifications, muscle bellies) that are located under the jaw and attach to the base of the cranium and typically attaches to the hyoid apparatus via a common tendon." . [] oboInOwl:source "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "The digastric muscle (also digastricus) (named digastric as it has two bellies) is a small muscle located under the jaw. It lies below the body of the mandible, and extends, in a curved form, from the mastoid process to the symphysis menti. It belongs to the suprahyoid muscles group. A broad aponeurotic layer is given off from the tendon of the digastricus on either side, to be attached to body and greater cornu of the hyoid bone; this is termed the suprahyoid aponeurosis. Wikipedia:Digastric_muscle]." . [] oboInOwl:source "FEED:rd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "In most mammals there is a common tendon between the ant. and post. muscles, which also makes a connection to the hyoid apparatus, and then the other attachment is to the base of the cranium" . [] oboInOwl:source "ncithesaurus:Digastric_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "UMLS:C0224155" . [] oboInOwl:hasDbXref "MA:0002288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "digastric" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "musculus digastricus" . [] oboInOwl:hasDbXref "FMA:46291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "digastric" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "digastric muscle" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "digastricus" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001562 ; owl:annotatedTarget "musculus digastricus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget obo:UBERON_0008571 . [] oboInOwl:notes "mylohyoid nerve from inferior alveolar branch of mandibular nerve V3" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget _:genid117786 . _:genid117396 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget _:genid117788 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0010544 . [] oboInOwl:notes "body of hyoid bone and median raphe" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget _:genid117790 . _:genid117398 oboInOwl:hasDbXref "MFMO:0000084" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking right and left mylohyoid and the mandible." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0004302 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking R and L mylohyoid and the mandible.[FEED]" . [] oboInOwl:source "ncithesaurus:Mylohyoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "UMLS:C0224159" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "musculus mylohyoideus" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "mylohyoid" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "mylohyoideus" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "mylohyoideus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001564 ; owl:annotatedTarget "musculus mylohyoideus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget obo:UBERON_0008571 . _:genid117407 oboInOwl:notes "C1 via the hypoglossal nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget _:genid117801 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003724 . [] oboInOwl:notes "C1 via the hypoglossal nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget _:genid117803 . _:genid117409 oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget _:genid117805 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006633 . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000101 ; owl:annotatedTarget "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget _:genid117807 . _:genid117411 oboInOwl:hasDbXref "MFMO:0000068" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by the first cervical nerve (C1)." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0010760 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by C1.[FEED]" . _:genid117413 oboInOwl:source "ncithesaurus:Geniohyoid" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "UMLS:C0224160" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001423 . [] oboInOwl:hasDbXref "Wikipedia:Geniohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "geniohyoid" . _:genid117415 oboInOwl:hasDbXref "Wikipedia:Geniohyoid_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "geniohyoideus" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001509 . [] oboInOwl:hasDbXref "Wikipedia:Geniohyoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "geniohyoideus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Geniohyoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001565 ; owl:annotatedTarget "musculus geniohyoideus" . [] oboInOwl:notes "external laryngeal branch of the vagus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget _:genid117824 . _:genid117427 oboInOwl:notes "Anterior and lateral cricoid cartilage" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget _:genid117826 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003121 . [] oboInOwl:notes "Inferior cornu and lamina of the thyroid cartilage" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget _:genid117828 . [] oboInOwl:hasDbXref "MFMO:0000324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget "Intrinsic muscle of the larynx, innervated by the external division of the laryngeal nerve, a branch of the vagus nerve. It attaches to the anterolateral surface of the cricoid cartilage and the external surface of the thyroid cartilage." . [] oboInOwl:source "ncithesaurus:Cricothyroid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget "UMLS:C0224178" . [] oboInOwl:hasDbXref "Wikipedia:Cricothyroid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget "M. cricothyroideus" . [] oboInOwl:hasDbXref "FMA:46417", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001566 ; owl:annotatedTarget "musculus cricothyroideus" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget _:genid117836 . [] oboInOwl:hasDbXref "Wikipedia:Cheek", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "A fleshy subdivision of one side of the face bounded by an eye, ear and the nose." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002113" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "Surface structure that includes the scales, skin, and muscles that are located ventral and posterior to the eye.[TAO]" . _:genid117438 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "EMAPA:37451" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003822 . [] oboInOwl:source "ncithesaurus:Cheek" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "UMLS:C0007966" . _:genid117440 oboInOwl:hasDbXref "Wikipedia:Cheek" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "buccae" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001492 . [] oboInOwl:hasDbXref "Wikipedia:Cheek" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001567 ; owl:annotatedTarget "jowl" . _:genid117442 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014892 _:genid117444 ) ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001493 . _:genid117444 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000976, obo:UBERON_0001737 . _:genid117446 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001737, obo:UBERON_0006849 . _:genid117448 a owl:Restriction ; owl:onProperty obo:RO_0002373, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001737, obo:UBERON_0006810 . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001568 ; owl:annotatedTarget _:genid117849 . _:genid117450 oboInOwl:hasDbXref "MP:0002263" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001568 ; owl:annotatedTarget "The muscles associated with the larynx." ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001507 . [] oboInOwl:source "ncithesaurus:Laryngeal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001568 ; owl:annotatedTarget "UMLS:C0023054" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001568 ; owl:annotatedTarget "larynx muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001568 ; owl:annotatedTarget "muscle organ of larynx" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget obo:UBERON_0001575 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget _:genid117858 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget _:genid117860 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget _:genid117863 . [] oboInOwl:hasDbXref "VHOG:0000847", "Wikipedia:Genioglossus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0444009442" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000103 ; owl:annotatedTarget "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000847" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/genioglossus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010660" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BMZ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "Makes up bulk of tongue in frogs and salamanders; makes up entire tongue in caecilians.[AAO]" . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "see Intrinsic Tongue.[FEED]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010660" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000847" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.20587, DOI:10.1186/1471-213X-8-24 Table 7", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" . [] oboInOwl:source "AAO:0010660" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "Makes up bulk of tongue in frogs and salamanders; makes up entire tongue in caecilians." . [] oboInOwl:source "ncithesaurus:Genioglossus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001571 ; owl:annotatedTarget "UMLS:C0224194" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget obo:UBERON_0001575 . [] oboInOwl:notes "lingual process in horse" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget _:genid117882 . [] oboInOwl:hasDbXref "FEED:rd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010663" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BMZ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "Makes up part of the tongue in frogs and salamanders.[AAO]" . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "The hyoglossus is a muscle that attaches to the hyoid and tongue and is innervated by Cranial Nerve XII.[FEED]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010663" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" . [] oboInOwl:source "ncithesaurus:Hyoglossus_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "UMLS:C0224196" . [] oboInOwl:hasDbXref "Wikipedia:Hyoglossus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001572 ; owl:annotatedTarget "hyoglossus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget obo:UBERON_0001575 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget _:genid117892 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget _:genid117894 . [] oboInOwl:notes "tip and sides of tongue" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget _:genid117896 . [] oboInOwl:hasDbXref "Wikipedia:Styloglossus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget "The Styloglossus, the shortest and smallest of the three styloid muscles, arises from the anterior and lateral surfaces of the styloid process, near its apex, and from the stylomandibular ligament. Passing downward and forward between the internal and external carotid arteries, it divides upon the side of the tongue near its dorsal surface, blending with the fibers of the Longitudinalis inferior in front of the Hyoglossus; the other, oblique, overlaps the Hyoglossus and decussates with its fibers. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget "Styloglossus is a muscle that attaches to the tongue and stylohyal and is innervated by Cranial Nerve XII.[FEED]" . [] oboInOwl:source "ncithesaurus:Styloglossus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget "UMLS:C0224195" . [] oboInOwl:hasDbXref "Wikipedia:Styloglossus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001573 ; owl:annotatedTarget "musculus styloglossus" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget _:genid117902 . [] oboInOwl:notes "aponeurosis" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget _:genid117904 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget _:genid117906 . [] oboInOwl:hasDbXref "Wikipedia:Palatoglossus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget "The palatoglossus, glossopalatinus, or palatoglossal muscle is a small fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the glossopalatine arch. It arises from the anterior surface of the soft palate, where it is continuous with the muscle of the opposite side, and passing downward, forward, and lateralward in front of the palatine tonsil, is inserted into the side of the tongue, some of its fibers spreading over the dorsum, and others passing deeply into the substance of the organ to intermingle with the Transversus linguæ. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget "Palatoglossus is a muscle that attaches to the soft palate and the tongue and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" . [] oboInOwl:source "ncithesaurus:Palatoglossus_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget "UMLS:C1704249" . _:genid117498 oboInOwl:hasDbXref "Wikipedia:Palatoglossus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001574 ; owl:annotatedTarget "musculus palatoglossus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000947 . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget obo:UBERON_0000378 . [] oboInOwl:notes "check palatoglossus" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget _:genid117921 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000107 ; owl:annotatedTarget "A neuron whose cell body is within an autonomic ganglion." . [] oboInOwl:hasDbXref "Wikipedia:Muscles_of_tongue", "https://github.com/obophenotype/uberon/issues/331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget "A muscle organ that attaches the tongue to some other structure." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000825" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.20587 Kusakabe R, Kuratani S, Evolution and developmental patterning of the vertebrate skeletal muscles: perspectives from the lamprey. Developmental Dynamics (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget "main functions are altering the tongue's position allowing for protrusion, retraction, and side-to-side movement" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0001575 ; owl:annotatedTarget "All intrinsic and extrinsic muscles of the tongue are supplied by the hypoglossal nerve (CN XII), except for one of the extrinsic muscles, palatoglossus, which is innervated by the Vagus nerve CN X of the pharyngeal plexus." . _:genid117522 oboInOwl:is_inferred "true" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget obo:UBERON_0000378 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001514 . [] oboInOwl:source "FEED", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget _:genid117937 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget _:genid117939 . [] oboInOwl:hasDbXref "http://www.feedexp.org/wiki/Mammalian_Muscle_Ontology_Workshop" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget "The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget "The intrinsic tongue muscles are an integral part of the tongue that are innervated by Cranial Nerve XII.[FEED]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000748" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.20587 Kusakabe R, Kuratani S, Evolution and developmental patterning of the vertebrate skeletal muscles: perspectives from the lamprey. Developmental Dynamics (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0001576 ; owl:annotatedTarget "The main function of the intrinsic muscles is to provide shape. They are not involved with changing the position of the tongue and are not attached to bone" . [] oboInOwl:source "FEED", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget _:genid117949 . [] oboInOwl:hasDbXref "FEED:rd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "A muscle innervated by a facial nerve." . [] oboInOwl:source "ncithesaurus:Facial_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "UMLS:C0015460" . [] oboInOwl:hasDbXref "FMA:46751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "face muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "face muscle organ" . [] oboInOwl:hasDbXref "FMA:46751", "XAO:0001013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "facial muscle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "facial nerve innervated muscle" . [] oboInOwl:hasDbXref "FMA:46751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "muscle of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "muscle organ of face" . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "cranial-facial muscle" . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "cranio-facial muscle" . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "craniofacial muscle" . [] oboInOwl:hasDbXref "Wikipedia:Facial_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "mimetic muscles" . [] oboInOwl:hasDbXref "Wikipedia:Facial_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "muscle of facil expression" . [] oboInOwl:hasDbXref "Wikipedia:Facial_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "muscles of facial expression" . [] oboInOwl:hasDbXref "Wikipedia:Facial_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001577 ; owl:annotatedTarget "musculi faciei" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget obo:UBERON_0003660 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget _:genid117967 . [] oboInOwl:notes "branches of the facial nerve and Zygomatic branches of Facial Nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget _:genid117969 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget _:genid117971 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget _:genid117973 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget _:genid117975 . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oculi_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget "A circumorbital muscle in the face that closes the eyelid[HP]." . [] oboInOwl:source "ncithesaurus:Orbicularis_Oculi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget "UMLS:C0224122" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oculi_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget "orbicularis oculi" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oculi_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget "musculus orbicularis oculi" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000108 ; owl:annotatedTarget "A neuron that uses acetylcholine as a vesicular neurotransmitter." . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oculi_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001578 ; owl:annotatedTarget "tensor tarsi" . [] oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:notes "zygomatic branch" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget _:genid117984 . [] oboInOwl:notes "Skin and muscle of the upper lip" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget _:genid117986 . [] oboInOwl:notes "Skin and muscle of the upper lip" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget _:genid117988 . [] oboInOwl:hasDbXref "Wikipedia:Levator_labii_superioris" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget "The levator labii superioris (or quadratus labii superioris) is a broad sheet, the origin of which extends from the side of the nose to the zygomatic bone. Its medial fibers form the angular head, which arises by a pointed extremity from the upper part of the frontal process of the maxilla and passing obliquely downward and lateralward divides into two slips. One of these is inserted into the greater alar cartilage and skin of the nose; the other is prolonged into the lateral part of the upper lip, blending with the infraorbital head and with the Orbicularis oris. The intermediate portion or infraorbital head arises from the lower margin of the orbit immediately above the infraorbital foramen, some of its fibers being attached to the maxilla, others to the zygomatic bone. Its fibers converge, to be inserted into the muscular substance of the upper lip between the angular head and the Caninus. The lateral fibers, forming the zygomatic head, arise from the malar surface of the zygomatic bone immediately behind the zygomaticomaxillary suture and pass downward and medialward to the upper lip. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget "EMAPA:37503" . [] oboInOwl:source "ncithesaurus:Levator_Labii_Superioris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget "UMLS:C1704248" . [] oboInOwl:hasDbXref "Wikipedia:Levator_labii_superioris" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001580 ; owl:annotatedTarget "musculus levator labii superioris" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000111 ; owl:annotatedTarget "OBSOLETE A neuron that is part of nerve found outside the central nervous system." . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget _:genid117995 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget _:genid117997 . [] oboInOwl:notes "oblique line of the mandible between the symphysis and the mental foramen" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget _:genid117999 . [] oboInOwl:notes "integument of the lower lip Orbicularis oris fibers its fellow of the opposite side" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget _:genid118001 . [] oboInOwl:notes "integument of the lower lip Orbicularis oris fibers its fellow of the opposite side" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget _:genid118003 . [] oboInOwl:hasDbXref "MFMO:0000123" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget "A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip, orbicularis oris muscle, and mandible, and superficial and lateral to the mentalis muscle. See Diogo et al., 2009; Burrows et al., 2011)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget "EMAPA:37516" . [] oboInOwl:source "ncithesaurus:Depressor_Labii_Inferioris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001581 ; owl:annotatedTarget "UMLS:C0224119" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000115 ; owl:annotatedTarget "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." . _:genid117590 oboInOwl:notes "buccal branch" ; oboInOwl:source "FEED" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget _:genid118020 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004363 . [] oboInOwl:notes "from the alveolar processes of the maxillary bone and mandible temporomandibular joint" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget _:genid118022 . [] oboInOwl:notes "dbpedia says: in the fibers of the orbicularis oris" ; oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget _:genid118024 . [] oboInOwl:hasDbXref "FEED:cw", "FEED:rd", "MFMO:0000002", "http://www.feedexp.org/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "The buccinator is a muscle that is attached to the mandible, skin, pterygomandibular raphe and maxilla, and is innervated by Cranial Nerve VII and participates in oropharyngeal behavior." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "EMAPA:37453" . [] oboInOwl:source "ncithesaurus:Buccinator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "UMLS:C0224121" . [] oboInOwl:hasDbXref "MFMO:0000002", "NCBITaxon:9606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "trumpeters muscle" . [] oboInOwl:hasDbXref "MFMO:0000002" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "buccinatorius" . [] oboInOwl:hasDbXref "Wikipedia:Buccinator_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001582 ; owl:annotatedTarget "musculus buccinator" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Beilstein:1751215" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001584 ; owl:annotatedTarget "The subclavian artery that supplies the left pectoral appendage." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001584 ; owl:annotatedTarget "EMAPA:37100" . [] oboInOwl:source "ncithesaurus:Left_Subclavian_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001584 ; owl:annotatedTarget "UMLS:C0226262" . [] oboInOwl:hasDbXref "FMA:4694", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001584 ; owl:annotatedTarget "arteria subclavia (sinistra)" . _:genid117611 a owl:Restriction ; owl:onProperty obo:RO_0002179, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000153, obo:UBERON_0004363 . _:genid117613 a owl:Restriction ; owl:onProperty obo:RO_0002170, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002078, obo:UBERON_2001053 . [] oboInOwl:hasDbXref "Wikipedia:Superior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." . _:genid117615 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001195" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001530 . [] oboInOwl:source "ncithesaurus:Superior_Vena_Cava" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "UMLS:C0042459" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "superior caval vein" . [] oboInOwl:hasDbXref "FMA:4720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "superior vena cava" . [] oboInOwl:hasDbXref "VHOG:0001195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "cranial vena cava" . [] oboInOwl:hasDbXref "NIFSTD:sao1415726815" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000119 ; owl:annotatedTarget "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." . [] oboInOwl:hasDbXref "BTO:0002683", "Wikipedia:Superior_vena_cava" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "vena cava superior" . [] oboInOwl:hasDbXref "Wikipedia:Superior_vena_cava" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001585 ; owl:annotatedTarget "vena maxima" . [] oboInOwl:hasDbXref "Wikipedia:Internal_jugular_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001586 ; owl:annotatedTarget "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010236" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001586 ; owl:annotatedTarget "Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO]" . [] oboInOwl:source "ncithesaurus:Internal_Jugular_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001586 ; owl:annotatedTarget "UMLS:C0226550" . _:genid117628 oboInOwl:hasDbXref "EHDAA2:0000877" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001586 ; owl:annotatedTarget "internal jugular" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002457 . [] oboInOwl:hasDbXref "Wikipedia:Internal_jugular_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001586 ; owl:annotatedTarget "vena jugularis interna" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000120 ; owl:annotatedTarget "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." . _:genid117630 a owl:Restriction ; owl:onProperty obo:RO_0002170, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003711, obo:UBERON_0005622 . [] oboInOwl:hasDbXref "Wikipedia:Subclavian_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001587 ; owl:annotatedTarget "The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010510" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001587 ; owl:annotatedTarget "Vein which collects blood from the forelimb via the brachial veins and from the muscles and skin of the trunk via the anterior epigastric and lateral veins.[AAO]" . [] oboInOwl:source "ncithesaurus:Subclavian_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001587 ; owl:annotatedTarget "UMLS:C0038532" . [] oboInOwl:hasDbXref "Wikipedia:Subclavian_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001587 ; owl:annotatedTarget "vena subclavia" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001591 ; owl:annotatedTarget "A vein that drains blood from the thymus." . [] oboInOwl:source "ncithesaurus:Thymic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001591 ; owl:annotatedTarget "UMLS:C0226698" . [] oboInOwl:hasDbXref "Wikipedia:Thymic_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001591 ; owl:annotatedTarget "vena thymica" . [] oboInOwl:hasDbXref "Wikipedia:Thymic_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001591 ; owl:annotatedTarget "venae thymicae" . [] oboInOwl:hasDbXref "Wikipedia:Bronchial_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001592 ; owl:annotatedTarget "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." . [] oboInOwl:hasDbXref "MESH:D011689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000121 ; owl:annotatedTarget "The output neuron of the cerebellar cortex." . [] oboInOwl:source "ncithesaurus:Bronchial_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001592 ; owl:annotatedTarget "UMLS:C0226650" . [] oboInOwl:hasDbXref "Wikipedia:Venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001593 ; owl:annotatedTarget "A congregation of multiple veins." . [] oboInOwl:hasDbXref "Wikipedia:Venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001593 ; owl:annotatedTarget "plexus venosus" . [] oboInOwl:hasDbXref "Wikipedia:Venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001593 ; owl:annotatedTarget "rete venosum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget obo:UBERON_0003681 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget _:genid118099 . [] oboInOwl:notes "zygomatic arch and maxilla" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget _:genid118103 . [] oboInOwl:hasDbXref "MESH:D009457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000125 ; owl:annotatedTarget "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." . [] oboInOwl:notes "zygomatic arch and maxilla" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget _:genid118105 . [] oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget _:genid118107 . [] oboInOwl:hasDbXref "DOI:10.1093/icb/icr067", "MFMO:0000075" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000823" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.333-334 and same reference Table 10-4", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati)" . [] oboInOwl:source "ncithesaurus:Masseter_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "UMLS:C0024876" . _:genid117676 oboInOwl:hasDbXref "BTO:0001755", "FMA:48996", "MA:0002343" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "masseter" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001361 . [] oboInOwl:hasDbXref "Wikipedia:Masseter_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001597 ; owl:annotatedTarget "musculus masseter" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget _:genid118116 . [] oboInOwl:notes "coronoid process of the mandible." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget _:genid118119 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget _:genid118121 . _:genid117683 oboInOwl:hasDbXref "MFMO:0000085" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "Pharyngeal arch 1 muscle that is innervated by the deep temporal branches of the trigeminal nerve and attaches to the wall of the braincase (including the cranial vault) and mandible." ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001361 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "Pharyngeal arch 1 muscle that is innervated by the deep temporal nerves and attaches to the wall of the braincase and mandible.[FEED]" . _:genid117685 oboInOwl:source "MP:0004239" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000929" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.333-334 and Table 10-4", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Temporal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "UMLS:C0039487" . [] oboInOwl:hasDbXref "FMA:49006", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "musculus temporalis" . [] oboInOwl:hasDbXref "MA:0002390" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "temporalis" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000126 ; owl:annotatedTarget "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." . [] oboInOwl:hasDbXref "Wikipedia:Temporal_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001598 ; owl:annotatedTarget "musculus temporalis" . _:genid117693 a owl:Restriction ; owl:onProperty obo:RO_0002371, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001361, obo:UBERON_0001687 . _:genid117695 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544, obo:UBERON_0001756 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget _:genid118136 . [] oboInOwl:notes "neck of stapes" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget _:genid118139 . [] oboInOwl:hasDbXref "Wikipedia:Stapedius_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget "The muscle that stabilizes the stapes bone. The stapedius emerges from a pinpoint foramen in the apex of the pyramidal eminence (a hollow, cone-shaped prominence in the posterior wall of the tympanic cavity), and inserts into the neck of the stapes. [WP,unvetted]." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "CAS:107-35-7" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "MESH:D001253", "PMID:11746784", "PMID:12162730", "PMID:12898703", "PMID:20942978", "http://en.wikipedia.org/wiki/Astrocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000127 ; owl:annotatedTarget "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000813" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.398", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget "The depressor mandibulae of tetrapods, which opens the jaws, is the homologue of the levator operculi and epihyoidean. In mammals, the depressor mandibulae evolves into the stapedius (...).[well established][VHOG]" . _:genid117701 oboInOwl:source "ncithesaurus:Stapedius_Muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget "UMLS:C0038151" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544 . [] oboInOwl:hasDbXref "EHDAA2:0001909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget "stapedius" . [] oboInOwl:hasDbXref "Wikipedia:Stapedius_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001599 ; owl:annotatedTarget "musculus stapedius" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget _:genid118150 . [] oboInOwl:notes "medial pterygoid nerve from the mandibular nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget _:genid118153 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget _:genid118156 . [] oboInOwl:notes "handle of the malleus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget _:genid118158 . [] oboInOwl:hasDbXref "Wikipedia:Tensor_tympani_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "The larger of the two muscles of the tympanic cavity, is contained in the bony canal above the osseous portion of the auditory tube. Its role is to dampen sounds produced from chewing. It arises from the cartilaginous portion of the auditory tube and the adjoining part of the great wing of the sphenoid, as well as from the osseous canal in which it is contained. Passing backward through the canal, it ends in a slender tendon which enters the tympanic cavity, makes a sharp bend around the extremity of the septum, known as the processus cochleariformis[1], and is inserted into the manubrium of the malleus, near its root[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000698" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.333-334 and same reference Table 10-4", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "The division of the adductor mandibulae in the various lines of tetrapod evolution correlates with divergences in their methods of feeding. (...) As the jaws become stronger and their movements more complex in the line of evolution toward mammals, the adductor complex becomes divided into several distinct muscles (temporalis, masseter, pterygoideus, tensor tympani, tensor veli palati).[well established][VHOG]" . _:genid117716 oboInOwl:source "ncithesaurus:Tensor_Tympani" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "UMLS:C0039529" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001363 . [] oboInOwl:hasDbXref "Wikipedia:Tensor_tympani_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "tensor tympani muscle" . [] oboInOwl:hasDbXref "Wikipedia:Tensor_tympani_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "M. tensor tympani" . [] oboInOwl:hasDbXref "Wikipedia:Tensor_tympani_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "musculus tensor tympani" . [] oboInOwl:hasDbXref "Wikipedia:Tensor_tympani_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001600 ; owl:annotatedTarget "tympanic muscle" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget _:genid118167 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget _:genid118169 . _:genid117723 oboInOwl:source "HPO:pr" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget _:genid118171 ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget _:genid118173 . [] oboInOwl:hasDbXref "GO:0002074", "Wikipedia:Extraocular_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "Skeletal muscle derived from cranial mesoderm and controls eye movements." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000549" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/extraocular+muscle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "Any of the six small muscles that control movement of the eyeball within the socket. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010028" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "Muscles surrounding the eye (bulbus oculi) and having an effect on eye movements.[AAO]" . _:genid117728 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000549" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these (extrinsic ocular) muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "BTO and MA consider this part of the eye; we follow them here (inferred from skeletal muscle). Not clear if omission from FMA is deliberate." . [] oboInOwl:hasDbXref "FMA:49033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extraocular muscle" . [] oboInOwl:hasDbXref "ZFA:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extraocular musculature" . [] oboInOwl:hasDbXref "MA:0001271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extraocular skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extrinsic eye muscle" . [] oboInOwl:hasDbXref "FMA:49033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extrinsic muscle of eyeball" . [] oboInOwl:hasDbXref "EHDAA2:0000482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "extrinsic ocular muscle" . [] oboInOwl:hasDbXref "Wikipedia:Extraocular_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001601 ; owl:annotatedTarget "musculi externi bulbi oculi" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget obo:UBERON_0006533 . [] oboInOwl:notes "inferior division of the oculomotor nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget _:genid118189 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget obo:CL_0000126 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget obo:UBERON_0001603 . [] oboInOwl:hasDbXref "Wikipedia:Medial_rectus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "The medial rectus muscle is a muscle in the orbit. As with most of the muscles of the orbit, it is innervated by the inferior division of the oculomotor nerve (Cranial Nerve III). This muscle shares an origin with several other extrinsic eye muscles, the anulus tendineus, or common tendon. It is the largest of the extraocular muscles and its only action is adduction of the eyeball. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001127" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Medial_Rectus_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "UMLS:C0582820" . [] oboInOwl:hasDbXref "FMA:49037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "medial rectus" . [] oboInOwl:hasDbXref "MA:0001281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "medial rectus extraocular muscle" . [] oboInOwl:hasDbXref "AAO:0010113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "musculus rectus medialis" . [] oboInOwl:hasDbXref "ZFA:0000301" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "medial recti" . _:genid117748 oboInOwl:hasDbXref "Wikipedia:Medial_rectus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001602 ; owl:annotatedTarget "musculus rectus medialis bulbi" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007026 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget obo:UBERON_0006533 . [] oboInOwl:hasDbXref "MESH:D009836", "http://en.wikipedia.org/wiki/Oligodendrocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget _:genid118201 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_rectus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "The lateral rectus muscle is a muscle in the orbit. It is one of six extraocular muscles that control the movements of the eye (abduction in this case) and the only muscle innervated by the abducens nerve, cranial nerve VI. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010107" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "Cranial nerve VI innervated; lateral in the rectus group.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001129" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Lateral_Rectus_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "UMLS:C0582821" . [] oboInOwl:hasDbXref "FMA:49038" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "lateral rectus" . [] oboInOwl:hasDbXref "MA:0001280" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "lateral rectus extraocular muscle" . [] oboInOwl:hasDbXref "AAO:0010107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "musculus rectus lateralis" . [] oboInOwl:hasDbXref "ZFA:0000383", "ZFIN:ZDB-PUB-970121-6" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "posterior rectus" . [] oboInOwl:hasDbXref "ZFA:0000383" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "lateral recti" . [] oboInOwl:hasDbXref "PMID:8734446" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000128 ; owl:annotatedTarget "OLs" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_rectus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001603 ; owl:annotatedTarget "musculus rectus lateralis bulbi" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001604 ; owl:annotatedTarget obo:UBERON_0001601 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001604 ; owl:annotatedTarget _:genid118214 . [] oboInOwl:hasDbXref "Wikipedia:Levator_palpebrae_superioris" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001604 ; owl:annotatedTarget "The levator palpebrae superioris (or levator muscle of upper eyelid) is the muscle in the orbit that elevates the superior (upper) eyelid. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Levator_Palpebrae_Superioris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001604 ; owl:annotatedTarget "UMLS:C0224134" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget obo:UBERON_0003386 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget obo:UBERON_0011222 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget _:genid118222 . _:genid117771 oboInOwl:hasDbXref "Wikipedia:Ciliary_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:source "ncithesaurus:Ciliary_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "UMLS:C0559230" . _:genid117773 oboInOwl:hasDbXref "BTO:0000654" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "musculus ciliarus" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001685 . [] oboInOwl:hasDbXref "BTO:0000654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "Bowman`s muscles" . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "ciliaris" . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001605 ; owl:annotatedTarget "musculus ciliaris" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001606 ; owl:annotatedTarget obo:UBERON_0011222 . [] oboInOwl:hasDbXref "Wikipedia:Iris_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001606 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001606 ; owl:annotatedTarget "iris muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001606 ; owl:annotatedTarget "muscle organ of iris" . (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) . ( ) . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget obo:UBERON_0004234 . _:genid117790 oboInOwl:source "ISBN:0781772214" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget _:genid118244 ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003999 . [] oboInOwl:notes "encircles iris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget _:genid118246 . [] oboInOwl:notes "encircles iris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget _:genid118248 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget _:genid118250 . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "A sphincter muscle that is part of the iris." . [] oboInOwl:source "ncithesaurus:Sphincter_Pupillae_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "UMLS:C0229189" . [] oboInOwl:hasDbXref "BTO:0000656" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "iris sphincter muscle" . [] oboInOwl:hasDbXref "BTO:0000656" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "musculus sphincter pupillae" . [] oboInOwl:hasDbXref "BTO:0000656" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "sphincter muscle of pupil" . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "circular fibers" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "CAS:107-35-7" . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "constrictor pupillae" . _:genid117801 oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "iris constrictor muscle" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "iris sphincter" . _:genid117803 oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "m. sphincter pupillae" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001780 . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "pupillary constrictor muscle" . _:genid117805 oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "pupillary sphincter" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006606 . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "pupillary sphincter muscle" . _:genid117807 oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "sphincter pupillae" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001685 . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "sphincter pupillae muscle" . [] oboInOwl:hasDbXref "Wikipedia:Iris_sphincter_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001607 ; owl:annotatedTarget "spincter pupillae" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget obo:UBERON_0004234 . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget _:genid118269 . [] oboInOwl:notes "outer margins of iris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget _:genid118271 . [] oboInOwl:notes "inner margins of iris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget _:genid118273 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget _:genid118275 . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Dilator_Pupillae_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "UMLS:C0229190" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "dilator pupillae muscle" . [] oboInOwl:hasDbXref "BTO:0001371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "iris dilator muscle" . [] oboInOwl:hasDbXref "FMA:49158", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "musculus dilatator pupillae" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "pupillary dilator muscle" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "radial muscle of iris" . [] oboInOwl:hasDbXref "BTO:0001371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "dilator pupillae muscle" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "iris dilator" . _:genid117824 oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "musculus dilatator pupillae" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001759 . [] oboInOwl:hasDbXref "BTO:0001371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "musculus dilator pupillae" . _:genid117826 oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "pupil dilator" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002375 . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "pupil dilator muscle" . _:genid117828 oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "pupillary dilator" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001738 . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "pupillary muscle" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "radial muscle" . [] oboInOwl:hasDbXref "Wikipedia:Iris_dilator_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001608 ; owl:annotatedTarget "radiating fibers" . _:genid117836 oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget _:genid118298 ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001456 . [] oboInOwl:source "AA", "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget _:genid118300 . [] oboInOwl:hasDbXref "Wikipedia:Lingual_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget "The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010492" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget "Part of the external carotid which supplies blood to the tongue.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010492" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget "relationship loss: part_of external carotid (AAO:0010218)[AAO]" . [] oboInOwl:source "ncithesaurus:Lingual_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget "UMLS:C0226104" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001610 ; owl:annotatedTarget "arteria lingualis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget _:genid118311 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "A branch of the lingual artery that supplies the sublingual gland." . _:genid117849 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010491" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "Part of the external carotid which supplies blood to the tip of the snout where branches go to the tongue and the m. geniohyoideus.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004478 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010491" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "relationship loss: part_of external carotid (AAO:0010218)[AAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "EMAPA:37115" . [] oboInOwl:source "ncithesaurus:Sublingual_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "UMLS:C0226106" . [] oboInOwl:hasDbXref "Wikipedia:Sublingual_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001611 ; owl:annotatedTarget "arteria sublingualis" . _:genid117858 a owl:Restriction ; owl:onProperty obo:RO_0002005, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001070, obo:UBERON_0001650 . _:genid117860 oboInOwl:hasDbXref "Wikipedia:Facial_artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001612 ; owl:annotatedTarget "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010059 . [] oboInOwl:source "ncithesaurus:Facial_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001612 ; owl:annotatedTarget "UMLS:C0226109" . [] oboInOwl:hasDbXref "Wikipedia:Facial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001612 ; owl:annotatedTarget "arteria maxillaris externa" . _:genid117863 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001637 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0000403 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002377 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001070 ] ) ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0009471 . [] oboInOwl:hasDbXref "Wikipedia:Occipital_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001613 ; owl:annotatedTarget "The occipital artery arises opposite the facial artery, its path is below the posterior belly of digastric to the occipital region. This artery supplies blood to the back of the scalp and sterno-mastoid muscles. Other muscles it supplies are deep muscles in the back and neck. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001613 ; owl:annotatedTarget "EMAPA:37672" . [] oboInOwl:source "ncithesaurus:Occipital_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001613 ; owl:annotatedTarget "UMLS:C0226117" . [] oboInOwl:hasDbXref "Wikipedia:Occipital_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001613 ; owl:annotatedTarget "arteria occipitalis" . [] oboInOwl:hasDbXref "Wikipedia:Maxillary_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001616 ; owl:annotatedTarget "An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]." . [] oboInOwl:source "http://download.videohelp.com/vitualis/med/Vascular_Devt.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001616 ; owl:annotatedTarget "...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries" . _:genid117882 oboInOwl:source "ncithesaurus:Maxillary_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001616 ; owl:annotatedTarget "UMLS:C0024949" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001685 . [] oboInOwl:hasDbXref "Wikipedia:Maxillary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001616 ; owl:annotatedTarget "arteria maxillaris" . [] oboInOwl:hasDbXref "Wikipedia:Mental_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001617 ; owl:annotatedTarget "The mental branch of inferior alveolar artery escapes with the nerve at the mental foramen, supplies the chin, and anastomoses with the submental and inferior labial arteries. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001617 ; owl:annotatedTarget "EMAPA:37105" . _:genid117892 oboInOwl:source "ncithesaurus:Mental_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001617 ; owl:annotatedTarget "UMLS:C0226144" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 . [] oboInOwl:hasDbXref "FMA:49701", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001617 ; owl:annotatedTarget "ramus mentalis (arteria alveolaris inferior)" . _:genid117894 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001637 _:genid117896 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001582 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 ] ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0003960 . _:genid117896 a owl:Restriction ; owl:onProperty obo:RO_0002178, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001567, obo:UBERON_0001723 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "CAS:107-35-7" . _:genid117902 oboInOwl:hasDbXref "Wikipedia:Buccal_artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001618 ; owl:annotatedTarget "The buccal artery (buccinator artery) is small and runs obliquely forward, between the Pterygoideus internus and the insertion of the Temporalis, to the outer surface of the Buccinator, to which it is distributed, anastomosing with branches of the external maxillary and with the infraorbital. [WP,unvetted]." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000929 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001618 ; owl:annotatedTarget "EMAPA:37073" . _:genid117904 oboInOwl:source "ncithesaurus:Buccal_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001618 ; owl:annotatedTarget "UMLS:C0226151" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0003216 . [] oboInOwl:hasDbXref "Wikipedia:Buccal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001618 ; owl:annotatedTarget "arteria buccalis" . _:genid117906 oboInOwl:hasDbXref "Wikipedia:Buccal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001618 ; owl:annotatedTarget "arteria buccinatoria" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001723 . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010497" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "Part of internal carotid which carries blood via branches to the eye, the eye muscles, and eyelids.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010497" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "relationship loss: part_of internal carotid (AAO:0010219)[AAO]" . [] oboInOwl:source "ncithesaurus:Opthalmic_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "UMLS:C0029078" . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "arteria ophthalmica" . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001619 ; owl:annotatedTarget "opthalmic artery" . [] oboInOwl:notes "proximal portion" ; oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget _:genid118381 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget _:genid118383 . [] oboInOwl:hasDbXref "Wikipedia:Central_retinal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget "The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget "EMAPA:37113" . [] oboInOwl:source "ncithesaurus:Retinal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget "UMLS:C0035301" . _:genid117921 oboInOwl:hasDbXref "Wikipedia:Central_retinal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget "arteria centralis retinae" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 . [] oboInOwl:hasDbXref "Wikipedia:Central_retinal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001620 ; owl:annotatedTarget "central artery of the retina" . [] oboInOwl:hasDbXref "Wikipedia:Coronary_circulation#Coronary_anatomy", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001621 ; owl:annotatedTarget "An artery that supplies the myocardium." . [] oboInOwl:source "ncithesaurus:Coronary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001621 ; owl:annotatedTarget "UMLS:C0205042" . [] oboInOwl:hasDbXref "ZFA:0005812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001621 ; owl:annotatedTarget "coronary vessel" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001622 ; owl:annotatedTarget _:genid118399 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001622 ; owl:annotatedTarget "The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001622 ; owl:annotatedTarget "EMAPA:37094" . [] oboInOwl:source "ncithesaurus:Lacrimal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001622 ; owl:annotatedTarget "UMLS:C0226171" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001622 ; owl:annotatedTarget "a. lacrimalis" . _:genid117937 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget obo:UBERON_0015156 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001650 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nasal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget "The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted]." . _:genid117939 oboInOwl:source "ncithesaurus:Dorsal_Nasal_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget "UMLS:C0226194" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010059 . [] oboInOwl:hasDbXref "FMA:50000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget "dorsal nasal branch of ophthalmic artery" . [] oboInOwl:hasDbXref "FMA:50000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget "external nasal artery" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nasal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001623 ; owl:annotatedTarget "arteria dorsalis nasi" . [] oboInOwl:source "FMA", "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001627 ; owl:annotatedTarget _:genid118411 . [] oboInOwl:hasDbXref "Wikipedia:Middle_cerebral_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001627 ; owl:annotatedTarget "The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it then branches and projects to many parts of the lateral cerebral cortex. It also supplies blood to the anterior temporal lobes and the insular cortices. The left and right MCAs rise from trifurcations of the internal carotid arteries and thus are connected to the anterior cerebral arteries and the posterior communicating arteries, which connect to the posterior cerebral arteries. The MCAs are not considered a part of the Circle of Willis. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Middle_Cerebral_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001627 ; owl:annotatedTarget "UMLS:C0149566" . [] oboInOwl:hasDbXref "Wikipedia:Middle_cerebral_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001627 ; owl:annotatedTarget "arteria cerebri media" . _:genid117949 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003066, obo:UBERON_0003709 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D017628", "PMID:11517395", "PMID:12430718", "PMID:14561199", "PMID:14612429", "PMID:16177057", "PMID:19461673", "PMID:2089275", "http://en.wikipedia.org/wiki/Microglia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget _:genid118422 . [] oboInOwl:source "FMA", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget _:genid118424 . [] oboInOwl:hasDbXref "Wikipedia:Posterior_communicating_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005001" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery. Isogai et al. 2001.[TAO]" . [] oboInOwl:source "ncithesaurus:Posterior_Communicating_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "UMLS:C0149559" . [] oboInOwl:hasDbXref "ZFA:0005001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "caudal communicating segment" . [] oboInOwl:hasDbXref "ZFA:0005001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "posterior communicating segment of the basilar artery" . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "hortega cells" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_communicating_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001628 ; owl:annotatedTarget "arteria cerebri communicans posterior" . [] oboInOwl:hasDbXref "GO:0007517" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001630 ; owl:annotatedTarget "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." . _:genid117967 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005145" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001630 ; owl:annotatedTarget "Portion of tissue composed of contractile fibers.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001245" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.75", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001630 ; owl:annotatedTarget "It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG]" . _:genid117969 oboInOwl:hasDbXref "ZFA:0005145" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001630 ; owl:annotatedTarget "muscle" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "microgliocyte" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001630 ; owl:annotatedTarget "EMAPA:37474" . _:genid117971 oboInOwl:source "TAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget _:genid118442 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000209 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget _:genid118444 . _:genid117973 oboInOwl:hasDbXref "Wikipedia:Thoracic_duct" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget "A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001680 . [] oboInOwl:source "FMA:5031" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget "Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein." . _:genid117975 oboInOwl:source "ZFA:0005110" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget "The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0004724 . [] oboInOwl:source "ncithesaurus:Thoracic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget "UMLS:C0039979" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001631 ; owl:annotatedTarget "ductus thoracicus" . [] oboInOwl:hasDbXref "PMID:23616747" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000129 ; owl:annotatedTarget "Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget _:genid118454 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget "A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain." . _:genid117984 oboInOwl:source "ZFA:0005002" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget "Artery that runs along the ventral keel of the hindbrain. It lies between the primordial hindbrain channels(PHBC). It irrigates the hindbrain and is connected, through the hindbrain, to the PHBC by the central arteries." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:source "MP:0013186" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget "The unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear[MP]." . _:genid117986 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000237" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1242/dev.058776 Fujita M, Cha YR, Pham VN, Sakurai A, Roman BL, Gutkind JS, Weinstein BM, Assembly and patterning of the vascular network of the vertebrate hindbrain. Development (2011)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget "The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates.[well established][VHOG]" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001458 . [] oboInOwl:source "ncithesaurus:Basilar_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001633 ; owl:annotatedTarget "UMLS:C0004811" . _:genid117988 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003472 [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001895 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0001905 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002178 ; owl:someValuesFrom obo:UBERON_0002037 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001633 ] ) ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001834 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000133 ; owl:annotatedTarget "Ectoderm destined to be nervous tissue." . ( ) . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Superior_cerebellar_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001635 ; owl:annotatedTarget "The superior cerebellar artery (SCA) arises near the termination of the basilar artery. It passes lateralward, immediately below the oculomotor nerve, which separates it from the posterior cerebral artery, winds around the cerebral peduncle, close to the trochlear nerve, and, arriving at the upper surface of the cerebellum, divides into branches which ramify in the pia mater and anastomose with those of the inferior cerebellar arteries. Several branches are given to the pineal body, the anterior medullary velum, and the tela chorioidea of the third ventricle. [WP,unvetted]." . _:genid117999 oboInOwl:source "ncithesaurus:Superior_Cerebellar_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001635 ; owl:annotatedTarget "UMLS:C0149575" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001684 . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Drug_Central:4486" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget obo:CL_0002320 . [] oboInOwl:hasDbXref "Wikipedia:Superior_cerebellar_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001635 ; owl:annotatedTarget "arteria superior cerebelli" . _:genid118001 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001835, obo:UBERON_0004572 . _:genid118003 oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001637 ; owl:annotatedTarget "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0010933 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010211" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001637 ; owl:annotatedTarget "Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001251" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001637 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001637 ; owl:annotatedTarget "UMLS:C0003842" . [] oboInOwl:hasDbXref "TAO:0000005" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001637 ; owl:annotatedTarget "arteries" . [] oboInOwl:hasDbXref "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." . [] oboInOwl:hasDbXref "Wikipedia:Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010212" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001743" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "UMLS:C0042449" . [] oboInOwl:hasDbXref "EMAPA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "vascular element" . [] oboInOwl:hasDbXref "Wikipedia:Vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "vena" . [] oboInOwl:hasDbXref "VHOG:0001743" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001638 ; owl:annotatedTarget "venae" . [] oboInOwl:hasDbXref "PMID:11378515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "marrow stromal cells" . _:genid118020 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647, obo:UBERON_0010194 . _:genid118022 a owl:Restriction ; owl:onProperty obo:RO_0002372, core:channels_into ; owl:someValuesFrom obo:UBERON_0002107, obo:UBERON_0004528 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget obo:UBERON_0002017 . _:genid118024 oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Hepatic_portal_vein", "http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011386 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000642" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.265", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "liver portal vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "portal vein of liver" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "portal vein" . [] oboInOwl:hasDbXref "ZFA:0005090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "primary hepatic portal vein" . [] oboInOwl:hasDbXref "PMID:11378515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "MSC" . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_portal_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001639 ; owl:annotatedTarget "vena portae hepatis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget obo:UBERON_0004573 . [] oboInOwl:notes "dorsal aorta in primitive verts" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget _:genid118506 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget _:genid118508 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget _:genid118510 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget _:genid118512 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget _:genid118514 . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "The first major branch of the abdominal aorta." . [] oboInOwl:source "ncithesaurus:Coeliac_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "UMLS:C0007569" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "coeliac artery" . [] oboInOwl:hasDbXref "MESH:D044982" ; oboInOwl:hasSynonymType cl:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "mesenchymal progenitor cells" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "arteria coeliaca" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "arteria cœliaca" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "celiac trunk" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "coeliac axis" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "coeliac trunck" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "coeliac trunk" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "truncus coeliacus" . [] oboInOwl:hasDbXref "Wikipedia:Celiac_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001640 ; owl:annotatedTarget "truncus cœliacus" . [] oboInOwl:hasSynonymType cl:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "mesenchymal stromal cells" . [] oboInOwl:hasDbXref "http://radiopaedia.org/articles/transverse-sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "One of the dural venous sinuses and drains the superior sagittal sinus the occipital sinus and the straight sinus, and empties into the sigmoid sinus which in turn reaches the jugular bulb." . [] oboInOwl:hasDbXref "Wikipedia:Transverse_sinuses" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "sinus transversus durae matris" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_sinuses" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "groove for right and left transverse sinuses" . [] oboInOwl:hasDbXref "FMA:50763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "lateral sinus" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_sinuses" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "sinus transversus" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_sinuses" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "transverse sinus" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_sinuses" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001641 ; owl:annotatedTarget "transverse sinus vein" . [] oboInOwl:hasDbXref "MESH:D044982" ; oboInOwl:hasSynonymType cl:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000134 ; owl:annotatedTarget "stem cells, mesenchymal" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget _:genid118547 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Oculomotor_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010468" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "Somatic efferent fibers which innervate four eye muscles.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000692" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1646", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "3n" . [] oboInOwl:source "BIRNLEX:1646", "ncithesaurus:Oculomotor_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "UMLS:C0028864" . [] oboInOwl:source "BIRNLEX:1646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "neuronames:488" . [] oboInOwl:hasDbXref "Wikipedia:Oculomotor_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "nervus oculomotorius" . [] oboInOwl:hasDbXref "FMA:50864", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "nervus oculomotorius [III]" . [] oboInOwl:hasDbXref "EHDAA2:0001284" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "oculomotor III" . [] oboInOwl:hasDbXref "NeuroNames:488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "nerve III" . [] oboInOwl:hasDbXref "BAMS:3n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001643 ; owl:annotatedTarget "oculomotor nerve or its root" . [] oboInOwl:hasDbXref "MESH:D017667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000136 ; owl:annotatedTarget "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Trochlear_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "A cranial nerve that runs to the eye muscles." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010469" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "Somatic efferent nerve which supplies a single eye muscle, the m. obliquus superior.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000705" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1654", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "4n" . [] oboInOwl:source "BIRNLEX:1654", "ncithesaurus:Trochlear_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "UMLS:C0041159" . [] oboInOwl:source "BIRNLEX:1654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "neuronames:466" . [] oboInOwl:hasDbXref "VHOG:0000705", "ZFA:0000600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "cranial nerve IV" . [] oboInOwl:hasDbXref "FMA:50865", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "nervus trochlearis [IV]" . [] oboInOwl:hasDbXref "MA:0001105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "trochlear IV nerve" . [] oboInOwl:hasDbXref "NeuroNames:466" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "nerve IV" . [] oboInOwl:hasDbXref "Wikipedia:Trochlear_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "nervus trochlearis" . [] oboInOwl:hasDbXref "VHOG:0000705" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "pathetic nerve" . [] oboInOwl:hasDbXref "VHOG:0000705" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "trochlear" . _:genid118099 oboInOwl:hasDbXref "BAMS:4n" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "trochlear nerve or its root" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Gmelin:82121" . [] oboInOwl:hasDbXref "BAMS:4n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001644 ; owl:annotatedTarget "trochlear nerve/root" . _:genid118103 a owl:Restriction ; owl:onProperty obo:RO_0002134, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000165, obo:UBERON_0002397 . _:genid118105 a owl:Restriction ; owl:onProperty obo:RO_0002134, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002500, obo:UBERON_0011648 . _:genid118107 a owl:Restriction ; owl:onProperty obo:RO_0002134, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001684, obo:UBERON_1000021 . [] oboInOwl:hasDbXref "GO_REF:0000034", "MESH:D019902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000138 ; owl:annotatedTarget "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget _:genid118592 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Trigeminal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010470" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000704" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . _:genid118116 oboInOwl:source "ISBN:0471888893" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000375 . [] oboInOwl:hasDbXref "BIRNLEX:869", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "5n" . [] oboInOwl:source "BIRNLEX:869", "ncithesaurus:Trigeminal_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "UMLS:C0040996" . _:genid118119 oboInOwl:source "BIRNLEX:869" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "neuronames:549" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0004660 . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "nervus trigeminus" . _:genid118121 oboInOwl:hasDbXref "FMA:50866", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "nervus trigeminus [v]" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0005467 . [] oboInOwl:hasDbXref "EHDAA2:0002084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "trigeminal V" . [] oboInOwl:hasDbXref "NeuroNames:549" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "nerve V" . [] oboInOwl:hasDbXref "BTO:0001072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "nervus trigeminus" . [] oboInOwl:hasDbXref "BTO:0001072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001645 ; owl:annotatedTarget "trigeminus" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget _:genid118613 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Abducens_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "Cranial nerve that runs to the eye muscles." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010471" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "Somatic motor nerve which bifurcates innervating m. rectus lateralis and m. retractor bulbi (eye muscles).[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000697" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . _:genid118136 oboInOwl:source "WP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "Homologous abducens nerves are found in all vertebrates except lampreys and hagfishes.[WP] It controls the movement of a single muscle, the lateral rectus muscle of the eye, in humans. In most other mammals it also innervates the musculus retractor bulbi, which can retract the eye for protection" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:hasDbXref "BIRNLEX:876", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "6n" . [] oboInOwl:source "BIRNLEX:876", "ncithesaurus:Abducens_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "UMLS:C0000741" . _:genid118139 oboInOwl:source "BIRNLEX:876" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "neuronames:550" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001687 . [] oboInOwl:hasDbXref "FMA:50867", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "nervus abducens [VI]" . [] oboInOwl:hasDbXref "BAMS:6n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "abducens nerve/root" . [] oboInOwl:hasDbXref "EMAPA:18216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "abducents VI nerve" . [] oboInOwl:hasDbXref "NeuroNames:550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "nerve VI" . [] oboInOwl:hasDbXref "Wikipedia:Abducens_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001646 ; owl:annotatedTarget "nervus abducens" . ( ) . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget _:genid118633 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget _:genid118635 . _:genid118153 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget _:genid118637 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000375 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget _:genid118639 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Facial_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches)." . _:genid118156 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010472" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:DSM" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "Slender nerve composed of branchiomotor and visceral efferent fibers innervating the mouth and various muscles within the jaw. Sensory components innervate the bucccal roof and somatomotor components innervate the depressor musculature and muscle interhyoideus.[AAO]" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002393 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000706" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . _:genid118158 oboInOwl:hasDbXref "BIRNLEX:827", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "7n" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0006722 . [] oboInOwl:source "BIRNLEX:827", "ncithesaurus:Facial_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "UMLS:C0015462" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000145 ; owl:annotatedTarget "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." . [] oboInOwl:source "BIRNLEX:827" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "neuronames:551" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "face nerve" . [] oboInOwl:hasDbXref "EHDAA2:0000489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "facial VII" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "nerve of face" . [] oboInOwl:hasDbXref "ZFA:0000664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "nervus facialis" . [] oboInOwl:hasDbXref "FMA:50868", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "nervus facialis [vii]" . [] oboInOwl:hasDbXref "BAMS:7n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "facial nerve or its root" . _:genid118167 oboInOwl:hasDbXref "BAMS:7n" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "facial nerve/root" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:hasDbXref "NeuroNames:551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "nerve VII" . _:genid118169 oboInOwl:hasDbXref "Wikipedia:Facial_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001647 ; owl:annotatedTarget "nervus facialis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003269 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000147 ; owl:annotatedTarget "A pigment cell is a cell that contains pigment granules." . (obo:UBERON_0001785 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001844 ] [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001720 ] ) . ( ) . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget _:genid118663 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Vestibulocochlear_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010473" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:DSM" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "Nerve primarily composed of special somatic afferent fibers innervating the inner ear, and is involved in balance, position, and hearing.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000695" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:890", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "8n" . [] oboInOwl:source "BIRNLEX:890", "ncithesaurus:Vestibulocochlear_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "UMLS:C0001162" . [] oboInOwl:source "BIRNLEX:890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "UMLS:C1278835" . [] oboInOwl:source "BIRNLEX:890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "neuronames:553" . [] oboInOwl:hasDbXref "FMA:50869" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "acoustic nerve" . [] oboInOwl:hasDbXref "FMA:50869", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "nervus vestibulocochlearis [viii]" . [] oboInOwl:hasDbXref "NeuroNames:553" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "nervus octavus" . [] oboInOwl:hasDbXref "NeuroNames:553" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "nervus statoacusticus" . _:genid118189 oboInOwl:hasDbXref "BTO:0003490" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001648 ; owl:annotatedTarget "nervus vestibulocochlearis" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001643 . [] oboInOwl:notes "sensory" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget _:genid118680 . [] oboInOwl:notes "motor" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget _:genid118682 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Glossopharyngeal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010474" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "Small nerve consisting of branchiomotor and visceral efferent and afferent fibers which innervate the m. subarculais rectus I, dorsal buccal mucosa, and the tongue.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000701" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:899", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "9n" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:10098958" . [] oboInOwl:source "BIRNLEX:899", "ncithesaurus:Glossopharyngeal_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "UMLS:C0017679" . _:genid118201 oboInOwl:source "BIRNLEX:899" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "UMLS:C1305752" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001646 . [] oboInOwl:source "BIRNLEX:899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "neuronames:701" . [] oboInOwl:hasDbXref "EHDAA2:0000709" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "glossopharyngeal IX" . [] oboInOwl:hasDbXref "ZFA:0000668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "nervus glossopharyngeus" . [] oboInOwl:hasDbXref "FMA:50870", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "nervus glossopharyngeus [ix]" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "CN-IX" . [] oboInOwl:hasDbXref "NeuroNames:701" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "nerve IX" . [] oboInOwl:hasDbXref "Wikipedia:Glossopharyngeal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001649 ; owl:annotatedTarget "nervus glossopharyngeus" . ( ) . [] oboInOwl:hasDbXref "ISBN:080184780X", "VHOG:0000693", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "Cranial nerve that innervates the muscles of the tongue." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000693" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "Cranial nerve that innervates muscles in the tongue. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-14, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:source "ISBN:080184780X" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "In amphibians, represents the hypoglossal nerve in amniotes. Innverates mm. geniohyoideus, genioglossus, hyoglossus, rectus cervicis" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010477" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "Nerve which innervates the muscles associated with the tongue including mm geniohyoideus, genioglossus, hyoglossus and rectus cervicis.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000693" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "Wikipedia:Cranial_nerves", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG]" . _:genid118222 oboInOwl:hasDbXref "BIRNLEX:820", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "12n" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 . [] oboInOwl:source "BIRNLEX:820", "ncithesaurus:Hypoglossal_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "UMLS:C0020614" . [] oboInOwl:source "BIRNLEX:820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "neuronames:704" . [] oboInOwl:hasDbXref "BIRNLEX:820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "cranial nerve XII" . [] oboInOwl:hasDbXref "EHDAA2:0000798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "hypoglossal XII" . [] oboInOwl:hasDbXref "FMA:50871", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "nervus hypoglossus [xii]" . [] oboInOwl:hasDbXref "VHOG:0000693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "CN-XII" . [] oboInOwl:hasDbXref "BAMS:12n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "hypoglossal nerve/ root" . [] oboInOwl:hasDbXref "NeuroNames:704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "nerve XII" . [] oboInOwl:hasDbXref "NeuroNames:704" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "nervi hypoglossalis" . [] oboInOwl:hasDbXref "Wikipedia:Hypoglossal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001650 ; owl:annotatedTarget "nervus hypoglossus" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001651 ; owl:annotatedTarget "The pulmonary artery that supplies the right lung." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001651 ; owl:annotatedTarget "EMAPA:37378" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget obo:CL_0000147 . [] oboInOwl:source "ncithesaurus:Right_Pulmonary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001651 ; owl:annotatedTarget "UMLS:C0923924" . [] oboInOwl:hasDbXref "Wikipedia:Right_pulmonary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001651 ; owl:annotatedTarget "arteria pulmonalis dextra" . _:genid118244 a owl:Restriction ; owl:onProperty obo:RO_0002178, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002168, obo:UBERON_0002346 . _:genid118246 a owl:Restriction ; owl:onProperty obo:RO_0002170, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001769, obo:UBERON_0002333 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001652 ; owl:annotatedTarget "The pulmonary artery that supplies the left lung." . _:genid118248 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001652 ; owl:annotatedTarget "EMAPA:37097" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001769 . [] oboInOwl:source "ncithesaurus:Left_Pulmonary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001652 ; owl:annotatedTarget "UMLS:C0923925" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000148 ; owl:annotatedTarget "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." . _:genid118250 oboInOwl:hasDbXref "Wikipedia:Left_pulmonary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001652 ; owl:annotatedTarget "arteria pulmonalis sinistra" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001608 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget _:genid118741 . [] oboInOwl:hasDbXref "Wikipedia:Facial_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010513" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "MA and NCITA also has 'anterior facial vein'" . [] oboInOwl:source "ncithesaurus:Facial_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "UMLS:C0226532" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "face vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "vein of face" . [] oboInOwl:hasDbXref "Wikipedia:Facial_vein" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "anterior facial vein" . [] oboInOwl:hasDbXref "Wikipedia:Facial_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001653 ; owl:annotatedTarget "vena facialis anterior" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001663 ; owl:annotatedTarget "The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001663 ; owl:annotatedTarget "EMAPA:37140" . [] oboInOwl:source "ncithesaurus:Cerebral_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001663 ; owl:annotatedTarget "UMLS:C0007797" . _:genid118269 oboInOwl:hasDbXref "Wikipedia:Cerebral_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001663 ; owl:annotatedTarget "venae cerebri" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000150 ; owl:annotatedTarget "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001663 ; owl:annotatedTarget "venae encephali" . _:genid118271 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001769, obo:UBERON_0003823 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget _:genid118762 . _:genid118273 oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget _:genid118764 ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001769 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget _:genid118766 . _:genid118275 oboInOwl:hasDbXref "Wikipedia:Triceps_surae_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "The triceps surae is a pair of muscles located at the calf - the gastrocnemius and the soleus. These muscles both insert into the calcaneus, the bone of the heel of the human foot, and form the major part of the muscle of the back part of the lower leg, commonly known as the calf muscle. The triceps surae is connected to the foot through the Achilles tendon, and has 3 heads deriving from the 2 major masses of muscle. The superficial portion (the gastrocnemius) gives off 2 heads attaching to the base of the femur directly above the knee. The deep (profundis) mass of muscle (the soleus) forms the remaining head which attaches to the superior posterior area of the tibia. The triceps surae is innervated by the tibial nerve, specifically, nerve roots L5-S2. [WP,unvetted]." ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001607 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "A set of muscles in FMA, a single organ in MA" . [] oboInOwl:source "ncithesaurus:Triceps_Surae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "UMLS:C0224458" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_surae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "calf muscle" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_surae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "gastrosoleus" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_surae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "gastrosoleus complex" . [] oboInOwl:hasDbXref "Wikipedia:Triceps_surae_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001665 ; owl:annotatedTarget "musculus triceps surae" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118775 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118777 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118779 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118781 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118783 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget _:genid118785 . [] oboInOwl:hasDbXref "Wikipedia:Tibialis_posterior_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "The Tibialis posterior is the most central of all the leg muscles, and is located in the posterior compartment of the leg. It is the key stabilizing muscle of the lower leg. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Tibialis_Caudalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "UMLS:C1711425" . [] oboInOwl:hasDbXref "BTO:0000867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "ibialis posticus" . [] oboInOwl:hasDbXref "Wikipedia:Tibialis_posterior_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "musculus tibialis posterior" . [] oboInOwl:hasDbXref "BTO:0000867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "posterior tibialis" . [] oboInOwl:hasDbXref "BTO:0000867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001667 ; owl:annotatedTarget "tibialis posterior muscle" . _:genid118298 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "A vein that drains the cerebellum." ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001723 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "EMAPA:37139" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:10325611" . _:genid118300 oboInOwl:source "ncithesaurus:Cerebellar_Vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "UMLS:C0226601" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001070 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "cerebellum vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "epencephalon-1 vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "vein of cerebellum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001668 ; owl:annotatedTarget "vein of epencephalon-1" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/masseteric-veins.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001674 ; owl:annotatedTarget "A plexiform vein accompanying the masseteric artery that empty into the pterygoid venous plexus." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001674 ; owl:annotatedTarget "EMAPA:37168" . _:genid118311 oboInOwl:source "ncithesaurus:Masseteric_Vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001674 ; owl:annotatedTarget "UMLS:C0925179" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001610 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001674 ; owl:annotatedTarget "masseteric veins" . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget obo:UBERON_0001800 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget _:genid118817 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.ncbi.nlm.nih.gov/books/NBK53171", "https://github.com/obophenotype/uberon/issues/693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000151 ; owl:annotatedTarget "A cell that specializes in controlled release of one or more substances." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000295" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "A prominent collection of touch-sensory neurons of the trigeminal or fifth cranial nerve, positioned beside the brain between the eye and the ear. Kimmel et al, 1995.[TAO]" . [] oboInOwl:source "PMID:21452441", "XAO:0004093" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "In Xenopus, the profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." . [] oboInOwl:source "ncithesaurus:Trigeminal_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "UMLS:C0040995" . [] oboInOwl:hasDbXref "ZFA:0000295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "5th ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "Gasserian ganglion" . [] oboInOwl:hasDbXref "ZFA:0000295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "fifth ganglion" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "ganglion of trigeminal complex" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "semilunar ganglion" . [] oboInOwl:hasDbXref "MA:0001080" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "trigeminal V ganglion" . [] oboInOwl:hasDbXref "NCBITaxon:32524" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "fused trigeminal ganglion" . [] oboInOwl:hasDbXref "BTO:0001231" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "Gasser's ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_ganglion" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "Gasserian ganglia" . [] oboInOwl:hasDbXref "BTO:0001231" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "ganglion of trigeminal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "ganglion semilunare" . [] oboInOwl:hasDbXref "BTO:0001231", "Wikipedia:Trigeminal_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "ganglion trigeminale" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001675 ; owl:annotatedTarget "trigeminal ganglia" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget obo:UBERON_0010428 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget _:genid118837 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget _:genid118839 . [] oboInOwl:notes "basi paired exo and supra occipital bones" ; oboInOwl:source "MA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget _:genid118841 . [] oboInOwl:notes "interparietal (postparietal)" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget _:genid118843 . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget _:genid118845 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "The bone at the lower, posterior part of the skull." . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII" . [] oboInOwl:source "Kardong" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "fusion of basi-, exo- and supra-occipitals (and maybe tabular)" . [] oboInOwl:source "ncithesaurus:Occipital_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "UMLS:C0028784" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/bones/braincase/occiput.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "occipital complex" . [] oboInOwl:hasDbXref "Wikipedia:Occipital_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001676 ; owl:annotatedTarget "os occipitale" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget obo:UBERON_0008193 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget _:genid118859 . [] oboInOwl:notes "orbito pre and basi sphenoid" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget _:genid118861 . [] oboInOwl:notes "pterygoid process" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget _:genid118863 . [] oboInOwl:notes "alisphenoid" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget _:genid118865 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget _:genid118867 . [] oboInOwl:hasDbXref "Wikipedia:Sphenoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "part of viscerocranium (facial skeleton) in FMA" . [] oboInOwl:source "ncithesaurus:Sphenoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "UMLS:C0037884" . [] oboInOwl:hasDbXref "FMA:52736", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "os sphenoidale" . [] oboInOwl:hasDbXref "Wikipedia:Sphenoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "butterfly bone" . [] oboInOwl:hasDbXref "Wikipedia:Sphenoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "os sphenoidale" . [] oboInOwl:hasDbXref "Wikipedia:Sphenoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001677 ; owl:annotatedTarget "os sphenoidum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget obo:UBERON_0008193 . [] oboInOwl:notes "petrosal" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget _:genid118877 . [] oboInOwl:notes "squamosal plus angular", "temporal series" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget _:genid118879 . [] oboInOwl:notes "styloid process" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget _:genid118881 . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000152 ; owl:annotatedTarget "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous." . [] oboInOwl:source "chond." ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "fusion of squamosal + angular (tympanic annulus) [derm.] + petrosal (prootic + opisthotic)" . [] oboInOwl:source "[WP]" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "The temporal bone consists of four parts: * Squama temporalis * Mastoid portion * Petrous portion (Petrosal ridge) * Tympanic part[WP]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "Note the Temporal bone is not explicitly categorized to a part of the cranium in FMA" . [] oboInOwl:source "ncithesaurus:Temporal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "UMLS:C0039484" . [] oboInOwl:hasDbXref "Wikipedia:Temporal_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001678 ; owl:annotatedTarget "os temporale" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000153 ; owl:annotatedTarget "A cell that secretes glycosaminoglycans." . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget obo:UBERON_0002513 . _:genid118381 oboInOwl:evidence "definitional" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget _:genid118893 ; owl:onProperty obo:RO_0002225 ; owl:someValuesFrom obo:UBERON_0002270 . [] oboInOwl:hasDbXref "Wikipedia:Ethmoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." . _:genid118383 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001317" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/ethmoid+bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG]" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001619 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001317" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.259", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "Note the WP states the Neurocranium contains the ethmoid bone, both MA and FMA place the ethmoid as part of the viscerocranium. FMA also has it in neurocranium (via basicranium). Ideally we would have non-overlapping divisions of the skull, but for now we follow FMA" . [] oboInOwl:source "ncithesaurus:Ethmoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "UMLS:C0015027" . [] oboInOwl:hasDbXref "FMA:52740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "ethmoid" . [] oboInOwl:hasDbXref "MP:0000101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "ethmoidal bone" . [] oboInOwl:hasDbXref "FMA:52740", "FMA:TA", "Wikipedia:Ethmoid" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001679 ; owl:annotatedTarget "os ethmoidale" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:notes "orbital series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget _:genid118905 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget _:genid118909 . [] oboInOwl:source "ZFA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget _:genid118911 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "The irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001149" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-3899370805 Arratia G, Schultze HP, Wilson MVH, Mesozoic Fishes 4 - Homology and Phylogeny (2008) p.23-48", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "The infraorbital bone 1 of actinopterygians is homologous with the lacrimal bone (...).[well established][VHOG]" . _:genid118399 oboInOwl:source "ncithesaurus:Lacrimal_Bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "UMLS:C0222733" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001619 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:10349454" . [] oboInOwl:hasDbXref "VHOG:0001149", "ZFA:0000223" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "infraorbital 1" . [] oboInOwl:hasDbXref "VHOG:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "lachrymal bone - infraorbital 1" . [] oboInOwl:hasDbXref "VHOG:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "lacrimal - infraorbital 1" . [] oboInOwl:hasDbXref "VHOG:0001149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "lacrymal bone - infraorbital 1" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001680 ; owl:annotatedTarget "os lacrimale" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget obo:UBERON_0010428 . [] oboInOwl:notes "facial series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget _:genid118924 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget _:genid118927 . _:genid118411 oboInOwl:hasDbXref "Wikipedia:Nasal_bone", "ZFIN:curator", "https://github.com/obophenotype/uberon/issues/265" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "One of two small oblong bones, varying in size and form in different individuals; they are placed side by side at the middle and upper part of the face, and form, by their junction, 'the bridge' of the nose[WP]. Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish[ZFA]." ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001532 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000312" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "Paired bone of intramembranous origin that roofs the olfactory capsule.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000365" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish Cubbage and Mabee, 1996.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000365" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "relationship loss: overlaps mesethmoid-nasal joint (TAO:0001677)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000312" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000365" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "Synonym adnasal used in Weitzman 1960, and synonym discussed in Vari 1995.[TAO]" . [] oboInOwl:source "ncithesaurus:Nasal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "UMLS:C0027422" . [] oboInOwl:hasDbXref "ZFA:0000365" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "nasal bones" . [] oboInOwl:hasDbXref "TAO:0000365" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "nasals" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001681 ; owl:annotatedTarget "os nasale" . _:genid118422 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0003709, obo:UBERON_0011156 . _:genid118424 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000924, obo:UBERON_0001532 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:source "Palaeos" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget obo:UBERON_0008907 . [] oboInOwl:notes "palatal series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget _:genid118944 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget _:genid118946 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget _:genid118948 . [] oboInOwl:hasDbXref "Wikipedia:Palatine_bone", "http://palaeos.com/vertebrates/bones/dermal/palatal-palatines.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "A paired dermal bone situated in the mid-palate that helps form the hard palate [Palaeos]." . [] oboInOwl:source "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget obo:NCBITaxon_32519 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000015" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:GA_TG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "Dermal bone that forms the antero-lateral region of the palate and is located ventral to the autopalatine. The dermopalatine is bilaterally paired and usually bears teeth.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:source "http://palaeos.com/vertebrates/glossary/glossaryD.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "Dermopalatine: same as palatine. The prefix is used by fish people because the palatine is a dermal replacement bone for a section of the autopalatine section of the palatoquadrate. In that context, palatine is potentially ambiguous.[Palaeos]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000015" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "In ostariophysans, the dermopalatine is absent.[TAO]" . [] oboInOwl:source "ncithesaurus:Palatine_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "UMLS:C0222734" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryD.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "dermopalatine" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "os palatinum" . [] oboInOwl:hasDbXref "Wikipedia:Palatine_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001682 ; owl:annotatedTarget "palatum" . _:genid118442 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002065, obo:UBERON_0011156 . _:genid118444 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0006210, obo:UBERON_0011156 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:notes "orbital series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget _:genid118965 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget _:genid118969 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget _:genid118971 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005270" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "The quadrilateral bone that forms the prominence of the cheek." . [] oboInOwl:source "Wikipedia:Jugal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "The jugal is a skull bone found in most reptiles, amphibians, and birds. In mammals, the jugal is often called the malar or Zygomatic. It is connected to the quadratojugal and maxilla, as well as other bones, which may vary by species. This bone is considered key in the determination of general traits of the skull, in the case of creatures, as with dinosaurs in paleontology, whose entire skull has not been found[Wikipedia:Jugal_bone]." . [] oboInOwl:source "Wikipedia:Zygomatic_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "The zygomatic bone is a paired dermal bone which articulates with the maxilla. In humans it also articulates with the temporal bone, the sphenoid bone and the frontal bone. The zygomatic is homologous to the jugal bone of other tetrapods. It is situated at the upper and lateral part of the face and forms the prominence of the cheek, part of the lateral wall and floor of the orbit, and parts of the temporal and infratemporal fossae. It presents a malar and a temporal surface; four processes, the frontosphenoidal, orbital, maxillary, and temporal; and four borders[WP,modified][Wikipedia:Zygomatic_bone]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001638" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-3899370805 Arratia G, Schultze HP, Wilson MVH, Mesozoic Fishes 4 - Homology and Phylogeny (2008) p.23-48", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "(...) and the infraorbital bone 3 of advanced actinopterygians (is homologous) with the jugal bone of sarcopterygians.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:52747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "malar bone" . _:genid118454 oboInOwl:hasDbXref "FMA:52747", "FMA:TA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "os zygomaticum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001535 . [] oboInOwl:hasDbXref "MA:0001497", "https://github.com/obophenotype/uberon/issues/121" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "zygomatic bone" . [] oboInOwl:hasDbXref "Wikipedia:Zygomatic_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "jugal" . [] oboInOwl:hasDbXref "GAID:225", "Wikipedia:Zygomatic_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "jugal bone" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "jugale" . [] oboInOwl:hasDbXref "Wikipedia:Zygomatic_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "os zygomaticum" . [] oboInOwl:hasDbXref "Wikipedia:Zygomatic_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "os zygomaticus" . [] oboInOwl:hasDbXref "GAID:225", "Wikipedia:Zygomatic_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001683 ; owl:annotatedTarget "zygoma" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget obo:UBERON_0002514 . [] oboInOwl:hasDbXref "Wikipedia:Human_mandible", "Wikipedia:Mandible" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "A dentary bone that is the only bone in one of the lateral halves of the lower jaw skeleton." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "Note in ZFA 'mandible' is a syn for the ventral mandibular arch, which is a portion of the 1st pharyngeal arch; however the term 'mandibular symphysis' refers to the dentary" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "lower jaw" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "lower jaw bone" . [] oboInOwl:source "ncithesaurus:Mandible" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "UMLS:C0024687" . [] oboInOwl:hasDbXref "Wikipedia:Mandible" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "lower mandibula" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000157 ; owl:annotatedTarget obo:CL_0000151 . [] oboInOwl:hasDbXref "BTO:0001748", "Wikipedia:Human_mandible" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "mandibula" . [] oboInOwl:hasDbXref "ZFA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001684 ; owl:annotatedTarget "mandibular series" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget _:genid119000 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget _:genid119002 . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000684" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "Paired processes that extend posterolaterally from the posterior margin of the hyoid plate. These processes are the ossified posteromedial processes and invest the laryngeal apparatus.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000684" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "relationship loss: part_of hyoid plate (AAO:0000664)[AAO]" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000157 ; owl:annotatedTarget "A cell that specializes in secretion of surfactant in the alveoli of the lung." . [] oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/548" ; oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "The hyoid bone is derived from the lower half of the second gill arch in fish, which separates the first gill slit from the spiracle. In many animals, it also incorporates elements of other gill arches, and has a correspondingly greater number of cornua. Amphibians and reptiles may have many cornua, while mammals (including humans) have two pairs, and birds only one. In birds, and some reptiles, the body of the hyoid is greatly extended forward, creating a solid bony support for the tongue. The howler monkey Alouatta has a pneumatized hyoid bone, one of the few cases of postcranial pneumatization of bones outside Saurischia." . [] oboInOwl:source "ncithesaurus:Hyoid_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "UMLS:C0020417" . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "hyoid" . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "hyoid bone" . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "hyoideum" . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "lingual bone" . [] oboInOwl:hasDbXref "Wikipedia:Hyoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001685 ; owl:annotatedTarget "os hyoideum" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget _:genid119018 . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget _:genid119020 . [] oboInOwl:source "PMID:11237469", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget _:genid119022 . [] oboInOwl:hasDbXref "Wikipedia:Auditory_ossicle", "https://github.com/obophenotype/uberon/issues/91" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "One of 3 small bones contained within the middle ear space and serve to transmit sounds from the air to the fluid-filled labyrinth. The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term 'ossicles' literally means 'tiny bones' and commonly refers to the auditory ossicles, though the term may refer to any small bone throughout the body. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000461" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/auditory+ossicles" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "The small bones of the middle ear: incus, malleus, and stapes. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000461" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.695", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "Additional structural analysis within a phylogenetic context has led to the remarkable discovery that in synapsids, thought to be ancestral to mammals, both the quadrate and articular have become reduced and less firmly articulated with their surrounding bones, reducing their jaw-joint-bearing role. This trend culminated with the incorporation of the quadrate, the columella (which remains articulated with the quadrate), and the articular into the expanded middle ear in mammals.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "Studies have shown that ear bones in mammal embryos are attached to the dentary, which is part of the jaw. These are ossified portions of cartilage -- called Meckel's cartilage -- that are attached to the jaw. As the embryo develops, the cartilage hardens to form bone. Later in development, the bone structure breaks loose from the jaw and migrates to the inner ear area. The structure is known as the middle ear, and is made up of the incus, stapes, malleus, and tympanic membrane. These correspond to the quadrate, prearticular, articular, and angular structures in the reptile jaw. For this reason, researchers believe the similarity of the results shows that mammals and reptiles have a common ancestry." . [] oboInOwl:hasDbXref "EMAPA:17824", "Wikipedia:Auditory_ossicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "ossicle" . [] oboInOwl:source "ncithesaurus:Auditory_Ossicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "UMLS:C0013450" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:10827156" . [] oboInOwl:hasDbXref "MP:0005105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "middle ear ossicle" . [] oboInOwl:hasDbXref "MA:0000254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "auditory ossicle" . [] oboInOwl:hasDbXref "MA:0000254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "ear bone" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "ear ossicles" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001686 ; owl:annotatedTarget "ossicular chain" . (obo:UBERON_0015016 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481 ] ) . ( ) . [] oboInOwl:contradicted_by "DOI:10.1111/j.1469-7580.2006.00524.x" ; oboInOwl:source "classical definition" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget _:genid119039 . _:genid118510 oboInOwl:source "definitional" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget _:genid119041 ; owl:onProperty core:indirectly_supplies ; owl:someValuesFrom obo:UBERON_0000945 . [] oboInOwl:hasDbXref "DOI:10.1111/j.1469-7580.2005.00441.x", "Wikipedia:Stapes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "The stapes or stirrup is the stirrup-shaped small bone or ossicle in the middle ear which is attached to the incus laterally and to the fenestra ovalis, the 'oval window' medially. The oval window is adjacent to the vestibule of the inner ear. The stapes is the smallest and lightest bone in the human body. The stapes transmits the sound vibrations from the incus to the membrane of the inner ear inside the fenestra ovalis. The stapes is also stabilized by the stapedius muscle, which is innervated by the facial nerve. In non-mammalian vertebrates, the bone homologous to the stapes is usually called the columella; however, in reptiles, either term may be used[WP,unvetted]." . _:genid118512 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000688" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" ; owl:onProperty core:indirectly_supplies ; owl:someValuesFrom obo:UBERON_0002106 . [] oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00441.x" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "As the stapes first develops embryologically from the 6th to 8th week of life, it surrounds the stapedial artery, which supplies the majority of the vasculature of the embryonic head. After that period, the external carotid artery is generated and takes over for the stapedial artery, which subsequently involutes, leaving the stapes with a windowframe-like structure[WP] The stapes develops at the cranial end of the second branchial arch through an independent anlage of the cartilage of this arch. Between the stapedial anlage and the cranial end of the Reichert's cartilage there is a formation called the interhyale, the internal segment of which gives rise to the tendon of the stapedial muscle. The stapedial anlage is a unique formation with two distinct parts: the superior part that will comprise the base and the inferior part that will be crossed by the stapedial artery during embryonic development and will constitute the limbs and the head of the stapes. According to the results, the otic capsule is not involved in formation of the base of the stapes." . _:genid118514 oboInOwl:source "ncithesaurus:Stapes" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "UMLS:C0038152" ; owl:onProperty core:indirectly_supplies ; owl:someValuesFrom obo:UBERON_0002107 . [] oboInOwl:hasDbXref "Wikipedia:Stapes" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "columella" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "columella auris" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "columellare" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "interstapediale" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "mediostapediale" . [] oboInOwl:hasDbXref "DOI:10.1183/09031936.00146609", "DOI:10.1378/chest.12-2762", "GOC:tfm", "PMID:28128362", "PMID:29874100", "PMID:7905712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000158 ; owl:annotatedTarget "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "mesostapediale" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "os columellare" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "os intermedium" . [] oboInOwl:hasDbXref "Wikipedia:Stapes" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "stapellos" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "stapes" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "stelidium" . [] oboInOwl:hasDbXref "AAO:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001687 ; owl:annotatedTarget "stilus columellare" . [] oboInOwl:source "EMAPA-implied" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget _:genid119063 . [] oboInOwl:hasDbXref "Wikipedia:Incus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget "The incus or anvil is the anvil-shaped small bone or ossicle in the middle ear. It connects the malleus to the stapes. It was first described by Alessandro Achillin of Bologna. The incus transmits sound vibrations from the malleus to the stapes. The incus only exists in mammals, and is derived from a reptilian upper jaw bone, the quadrate bone. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000689" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget "According to this theory (Reichert-Gaupp theory), the mammalian stapes is derived from the reptilian columella, the incus from the quadrate and the malleus from the articular (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000689" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget "quadrate - incus" . [] oboInOwl:source "ncithesaurus:Incus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget "UMLS:C0021181" . [] oboInOwl:hasDbXref "MA:0001215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001688 ; owl:annotatedTarget "incus" . [] oboInOwl:hasDbXref "MESH:D020397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000160 ; owl:annotatedTarget "A cell of the epithelial lining that produce and secrete mucins." . [] oboInOwl:is_redundant "true" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget _:genid119074 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget _:genid119076 . [] oboInOwl:hasDbXref "Wikipedia:Malleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "The malleus or hammer is a hammer-shaped small bone or ossicle of the middle ear which connects with the incus and is attached to the inner surface of the eardrum. The word is Latin for hammer. It transmits the sound vibrations from the eardrum to the incus. The malleus is unique to mammals, and evolved from a lower jaw bone in basal amniotes called the articular, which still forms part of the jaw joint in reptiles. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000690" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "According to this theory (Reichert-Gaupp theory), the mammalian stapes is derived from the reptilian columella, the incus from the quadrate and the malleus from the articular (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "anguloarticular - malleus" . [] oboInOwl:hasDbXref "MA:0001216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "malleus" . _:genid118547 oboInOwl:source "ncithesaurus:Malleus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "UMLS:C0024631" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010285 . [] oboInOwl:hasDbXref "Wikipedia:Malleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001689 ; owl:annotatedTarget "malleus" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget _:genid119087 . [] oboInOwl:hasDbXref "GO:0042471", "Wikipedia:Ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000330" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/ear" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "The organ of hearing and of equilibrium. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000330" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.20207 Boekhoff-Falk G, Hearing in Drosophila: Development of Johnston's organ and emerging parallels to vertebrate ear development. Developmental Dynamics (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1062", "ncithesaurus:Ear" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "UMLS:C0013443" . [] oboInOwl:source "BIRNLEX:1062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "UMLS:C0521421" . [] oboInOwl:hasDbXref "BTO:0000368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001690 ; owl:annotatedTarget "auris" . [] oboInOwl:hasDbXref "GO:0042473", "Wikipedia:External_ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO]." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget obo:NCBITaxon_9709 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000311" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "The external part of the organ, which consists of an outer portion (external auditory meatus) which leads to the tympanum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000311" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1007/s00359-008-0327-1 Schoffelen RLM, Segenhout JM, Van Dijk P, Mechanics of the exceptional anuran ear. Journal of Comparative Physiology A (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "Some species, like Amolops tormotus (Feng et al. 2006), have a cavity in front of the tympanic membrane which is considered to be an ear canal and thus an outer ear. (...) The ancestral lineage of amphibians separated from the mammalian lineage, approximately 350 million years ago, in the paleozoic era. Many of the important developments in the auditory systems emerged after the ancestral paths separated (Manley and Clack 2003). This implies that shared features, like the tympanic middle ear, developed independently in different vertebrate lineages.[uncertain][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "in XAO this includes and is only the tympanum" . [] oboInOwl:source "BIRNLEX:1705", "ncithesaurus:External_Ear" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "UMLS:C0013453" . [] oboInOwl:source "BIRNLEX:1705" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "UMLS:C1269548" . [] oboInOwl:hasDbXref "MA:0000258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "outer ear" . [] oboInOwl:hasDbXref "BTO:0002100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001691 ; owl:annotatedTarget "auris externa" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget _:genid119109 . [] oboInOwl:hasDbXref "Wikipedia:Petrous_part_of_the_temporal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001553" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "The petrosal bone arises from the two otic bones on the lateral wall of the chondrocranium and encases the inner ear of mammals. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.258, see_Liem_KF][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "petrosal" . [] oboInOwl:source "ncithesaurus:Ciliary_Process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "UMLS:C1261761" . [] oboInOwl:hasDbXref "FMA:52871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "pars petrosa (os temporale)" . [] oboInOwl:hasDbXref "FMA:52871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "petromastoid part of temporal bone" . [] oboInOwl:hasDbXref "FMA:52871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "petrosal bone" . [] oboInOwl:hasDbXref "FMA:52871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001694 ; owl:annotatedTarget "petrous bone" . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget obo:UBERON_0002514 . [] oboInOwl:notes "see comments" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget _:genid119120 . [] oboInOwl:notes "temporal series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget _:genid119122 . [] oboInOwl:source "EHDAA2", "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget _:genid119124 . [] oboInOwl:hasDbXref "MP:0004423", "Wikipedia:Squama_temporalis", "Wikipedia:Squamosal_bone", "https://github.com/obophenotype/uberon/issues/122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "A bone which is fused with the temporal bone in many mammals and forms part of the cheek region articulating with quadrate and pterygoid in other vertebrates." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000574" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "Paired, intramembranous bones that lie at the posterolateral margins of the skull. Lateral and dorsal to the quadrate.[AAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000161 ; owl:annotatedTarget obo:CL_0000151 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001561" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "The squamosal bone is part of the dermatocranium in early tetrapods and becomes part of the mammalian occipital and temporal bones. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.246, see_Liem_KF][VHOG]" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "os squamosum" . _:genid118592 oboInOwl:hasDbXref "FMA:52883", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "pars squamosa ossis temporalis" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005239 . [] oboInOwl:hasDbXref "Wikipedia:Squama_temporalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "squama temporalis" . [] oboInOwl:hasDbXref "AAO:0000574" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "squamosal" . [] oboInOwl:hasDbXref "MA:0001473", "https://github.com/obophenotype/uberon/issues/122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "squamosal bone" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "squamous bone" . [] oboInOwl:hasDbXref "MP:0004423", "VHOG:0001561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001695 ; owl:annotatedTarget "temporal bone squamous part" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:11162030" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget _:genid119140 . [] oboInOwl:hasDbXref "TAO:0001410", "Wikipedia:Orbit_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001410" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "in FMA, this overlaps with bones such as the maxilla and sphenoid; in ZFA, individual bones are part of the orbit" . [] oboInOwl:source "ncithesaurus:Orbit" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "UMLS:C0029180" . [] oboInOwl:hasDbXref "FMA:53074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "orbit of skull" . [] oboInOwl:hasDbXref "ZFA:0001410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001697 ; owl:annotatedTarget "orbit" . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget obo:UBERON_0001800 . _:genid118613 oboInOwl:notes "check for multi-species" ; oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget _:genid119154 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005239 . [] oboInOwl:source "EHDAA2:0004623", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget _:genid119156 . [] oboInOwl:source "EHDAA2:0004623" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget _:genid119158 . [] oboInOwl:source "EHDAA2:0000491" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget _:genid119160 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001082" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "The group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000707" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Geniculate_ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "geniculate" . [] oboInOwl:source "ncithesaurus:Geniculate_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "UMLS:C0017406" . [] oboInOwl:hasDbXref "MA:0001076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "facial VII ganglion" . [] oboInOwl:hasDbXref "ZFA:0001291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "gVII" . [] oboInOwl:hasDbXref "FMA:53414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "ganglion genicularum" . [] oboInOwl:hasDbXref "FMA:53414", "Wikipedia:Geniculate_ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "genicular ganglion" . [] oboInOwl:hasDbXref "ZFA:0001291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "facial ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Geniculate_ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "ganglion geniculi" . [] oboInOwl:hasDbXref "Wikipedia:Geniculate_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "ganglion geniculi nervi facialis" . [] oboInOwl:hasDbXref "MA:0001076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "geniculate ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Geniculate_ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001700 ; owl:annotatedTarget "internal genu" . ( ) . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget obo:UBERON_0009127 . _:genid118635 oboInOwl:notes "dorsal" ; oboInOwl:source "EHDAA2", "ISBN:0471888893", "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget _:genid119180 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:notes "ventrolateral" ; oboInOwl:source "EHDAA2", "ISBN:0471888893", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget _:genid119182 . _:genid118637 oboInOwl:hasDbXref "MP:0001096" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget "The group of neuron cell bodies associated with the ninth cranial nerve." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003066 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000702" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" . _:genid118639 oboInOwl:hasDbXref "FMA:53471" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget "ganglion of glosspharyngeal nerve" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005239 . [] oboInOwl:hasDbXref "MA:0001077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget "glossopharyngeal IX ganglion" . [] oboInOwl:hasDbXref "ZFA:0001301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001701 ; owl:annotatedTarget "petrosal ganglion" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001702 ; owl:annotatedTarget "Any of the hairs that grow at the edge of the upper or lower eyelid." . [] oboInOwl:source "ncithesaurus:Eyelash" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001702 ; owl:annotatedTarget "UMLS:C0015422" . [] oboInOwl:hasDbXref "Wikipedia:Eyelash" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001702 ; owl:annotatedTarget "cilia" . [] oboInOwl:hasDbXref "Wikipedia:Eyelash" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001702 ; owl:annotatedTarget "cilium" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001702 ; owl:annotatedTarget "eyelid cilia" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget obo:UBERON_0011158 . [] oboInOwl:hasDbXref "PMID:11523816", "TAO:MAH", "Wikipedia:Neuroranium", "ZFA:0001580" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001580" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "Anatomical cluster that consists of the cartilages and bones that surround the brain.[TAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ..." . [] oboInOwl:hasDbXref "ZFA:0001580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "brain case" . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/braincase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "brain pan" . [] oboInOwl:hasDbXref "ZFA:0001580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001703 ; owl:annotatedTarget "braincase" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget _:genid119207 . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget _:genid119209 . _:genid118663 oboInOwl:hasDbXref "Wikipedia:Nail_(anatomy)", "https://github.com/obophenotype/uberon/issues/120" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003069 . [] oboInOwl:source "ncithesaurus:Nail" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget "UMLS:C0027342" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget "nail/claw" . [] oboInOwl:hasDbXref "Wikipedia:Claw" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001705 ; owl:annotatedTarget "claw" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget _:genid119217 . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget _:genid119219 . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget _:genid119221 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_septum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000017" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "A median dividing wall, sagittally directed, which divides the nasal cavity into the right and the left nasal fossae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010135" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "Medial vertical wall between nasal capsules.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000559" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "Medial, vertical plate that separates the nasal capsules.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000017" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1098/rstb.2001.0976 Kuratani S, Nobusada Y, Horigome N, Shigetani Y, Embryology of the lamprey and evolution of the vertebrate jaw: insights from molecular and developmental perspectives. Philosophical transactions of the Royal Society of London (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "Whatever the common ancestor of the lamprey and gnathostomes may have looked like, it most likely possessed a neural-crest-derived premandibular ectomesenchyme closely associated with the NHP. Invention of the jaw subsequently required a space for the nasal septum and maxillary process to develop, which might have been provided by subdivision of the NHP into the nasal placode and the hypophysis (diplorhiny, the state of bilaterally separated nasal openings, would also have been a prerequisite for this).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Nasal_Septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "UMLS:C0027432" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "septal cartilage" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "septum mobile nasi" . _:genid118680 oboInOwl:hasDbXref "Wikipedia:Nasal_septum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "septum nasi" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003099 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001706 ; owl:annotatedTarget "septum of the nose" . _:genid118682 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005239, obo:UBERON_0005870 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget _:genid119234 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000314" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "Saclike space internal to the nasal capsule lined by respiratory and sensory epithelium and glandular tissue.[AAO]" . [] oboInOwl:source "Wikipedia:Nasal_cavity" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "a large air filled space above and behind the nose in the middle of the face[WP][Wikipedia:Nasal_cavity]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000271" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1666/0094-8373(2006)032[0109:NCHACC]2.0.CO;2 Evans DC, Nasal cavity homologies and cranial crest function in lambeosaurine dinosaurs. Paleobiology (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "Despite significant modification to the nasal cavity within Archosauria and its extreme hypertrophy and supraorbital development in Lambeosaurinae, the neural olfactory system and the olfactory region of the nasal cavity proper retain their plesiomorphic positions and associations, suggesting that this system is highly conserved in vertebrate evolution.[well established][VHOG]" . [] oboInOwl:source "HP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "in humans, the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures" . [] oboInOwl:source "ncithesaurus:Nasal_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "UMLS:C0027423" . [] oboInOwl:hasDbXref "MESH:D055098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000163 ; owl:annotatedTarget "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "cavity of olfactory apparatus" . [] oboInOwl:hasDbXref "ZFA:0000130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "nasal canal" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "nasal conduit space" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "nasal fossa" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "olfactory chamber cavity" . [] oboInOwl:hasDbXref "BTO:0002096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "cavitas nasalis" . [] oboInOwl:hasDbXref "BTO:0002096", "Wikipedia:Nasal_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "cavitas nasi" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "cavum nasi" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "olfactory chamber" . [] oboInOwl:hasDbXref "ZFA:0000130" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001707 ; owl:annotatedTarget "olfactory pit" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:11842876" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000164 ; owl:annotatedTarget "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget _:genid119257 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget _:genid119262 . [] oboInOwl:hasDbXref "Wikipedia:Jaw", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "Subdivision of skeleton which includes upper and lower jaw skeletons." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001227" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "Skeletal and cartilage elements of the first pharyngeal arch.[TAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates" . [] oboInOwl:source "ncithesaurus:Jaw" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "UMLS:C0022359" . [] oboInOwl:hasDbXref "MA:0001905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "jaw" . [] oboInOwl:hasDbXref "ZFA:0001227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "jaw cartilage" . [] oboInOwl:hasDbXref "ZFA:0001227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "mandibular arch skeleton" . [] oboInOwl:hasDbXref "TAO:0001227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001708 ; owl:annotatedTarget "mandibular arch" . [] oboInOwl:hasDbXref "Wikipedia:Upper_jaw", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000620" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000454" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "Note isa/partof difference MA/FMA" . [] oboInOwl:hasDbXref "FMA:59399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "maxillary part of mouth" . [] oboInOwl:hasDbXref "FMA:59399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "alveolodental arch of bimaxilla" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "dorsal pharyngeal arch 1" . [] oboInOwl:hasDbXref "FMA:59399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "maxillary part of mouth proper" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001709 ; owl:annotatedTarget "palatoquadrate arch" . [] oboInOwl:source "Wikipedia:Mandibular_prominence" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget _:genid119292 . [] oboInOwl:hasDbXref "Wikipedia:Lower_jaw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000272" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget "Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000453" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" . _:genid118741 oboInOwl:external_ontology "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget "Note isa/partof difference MA/FMA" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001586 . [] oboInOwl:hasDbXref "FMA:59398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001710 ; owl:annotatedTarget "mandibular part of mouth" . [] oboInOwl:source "multiple" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget _:genid119299 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "Consider adding 'eye surface', like MA" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "FMA divides this into skin, fascia, conjunctiva" . [] oboInOwl:hasDbXref "MESH:D055099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget "A neuron that is capable of some hormone secretion in response to neuronal signals." . [] oboInOwl:source "ncithesaurus:Eyelid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "UMLS:C0015426" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "blephara" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001711 ; owl:annotatedTarget "palpebrae" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000389" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.431", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001712 ; owl:annotatedTarget "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Upper_Eyelid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001712 ; owl:annotatedTarget "UMLS:C0585636" . [] oboInOwl:hasDbXref "FMA:54439", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001712 ; owl:annotatedTarget "palpebra superior" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000388" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.431", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001713 ; owl:annotatedTarget "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Lower_Eyelid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001713 ; owl:annotatedTarget "UMLS:C0229258" . [] oboInOwl:hasDbXref "FMA:54442", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001713 ; owl:annotatedTarget "palpebra inferior" . [] oboInOwl:hasDbXref "PMID:5342440", "https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0000165 ; owl:annotatedTarget """The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.""" . ( ) . _:genid118764 oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0001081", "PMID:9362461" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "The groups of nerve cell bodies associated with the twelve cranial nerves." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001450 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000013" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "Ganglion which is located in the head.[TAO]" . _:genid118766 oboInOwl:hasDbXref "BIRNLEX:2597" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "cranial ganglion part of peripheral nervous system" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003701 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "cranial neural tree organ ganglion" . [] oboInOwl:hasDbXref "FMA:54502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "ganglion of cranial nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "ganglion of cranial neural tree organ" . [] oboInOwl:hasDbXref "ZFA:0000013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001714 ; owl:annotatedTarget "presumptive cranial ganglia" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0007245 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget _:genid119329 . [] oboInOwl:hasDbXref "BIRNLEX:1240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "Nuclear complex containing subnuclei that give rise to the axons of the occulomotor nerve, both motor and parasympathetic fibers, situated at the midline at the level of the superior colliculus in the midbrain tegmentum (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533-534)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0001944 . _:genid118775 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0001947 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001323 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0001966 . _:genid118777 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002141 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000979 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002438 . _:genid118779 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002691 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001446 . [] oboInOwl:hasDbXref "MESH:D019439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000166 ; owl:annotatedTarget "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002696 . _:genid118781 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002722 ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001451 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0002995 . _:genid118783 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget obo:UBERON_0003040 ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001452 . [] oboInOwl:source "XAO:0004389" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "The nucleus of the oculomotor nerve (cranial nerve III)[XAO:0004389]." . _:genid118785 oboInOwl:source "BIRNLEX:1240", "ncithesaurus:Oculomotor_Nucleus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "UMLS:C0228686" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001385 . [] oboInOwl:source "BIRNLEX:1240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "neuronames:492" . [] oboInOwl:hasDbXref "XAO:0004389" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "OM" . [] oboInOwl:hasDbXref "FMA:54510", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "nucleus nervi oculomotorii" . [] oboInOwl:hasDbXref "FMA:54510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "nucleus of oculomotor nerve" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "nucleus of oculomotor nuclear complex" . [] oboInOwl:hasDbXref "FMA:54510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "nucleus of third cranial nerve" . [] oboInOwl:hasDbXref "MA:0001073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "oculomotor III nucleus" . [] oboInOwl:hasDbXref "FMA:54510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "oculomotor nucleus" . [] oboInOwl:hasDbXref "FMA:54510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "third cranial nerve nucleus" . [] oboInOwl:hasDbXref "NeuroNames:492" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "nucleus oculomotorius" . [] oboInOwl:hasDbXref "XAO:0004389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001715 ; owl:annotatedTarget "oculomotor motornucleus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget _:genid119355 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:11918831" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget _:genid119357 . [] oboInOwl:notes "fusion" ; oboInOwl:source "http://www.indiana.edu/~anat550/hnanim/face/face.html" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget _:genid119359 . [] oboInOwl:hasDbXref "Wikipedia:Secondary_palate", "http://www.indiana.edu/~anat550/hnanim/face/face.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "The part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences." . [] oboInOwl:hasDbXref "EMAPA:18948", "GO:0060021", "MA:0002476" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "palate" . [] oboInOwl:source "ncithesaurus:Palate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "UMLS:C0700374" . [] oboInOwl:source "ncithesaurus:Secondary_Palate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "UMLS:C1519217" . [] oboInOwl:hasDbXref "EMAPA:18948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "definitive palate" . [] oboInOwl:hasDbXref "Wikipedia:Secondary_palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "palatum definitivum" . [] oboInOwl:hasDbXref "Wikipedia:Secondary_palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "palatum secundarium" . [] oboInOwl:hasDbXref "Wikipedia:Palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001716 ; owl:annotatedTarget "palatum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001720 ; owl:annotatedTarget "Any of the nuclei of the cochlear nuclear complex." . _:genid118817 oboInOwl:hasDbXref "MA:0001012" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001720 ; owl:annotatedTarget "cochlear VIII nucleus" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006304 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget obo:UBERON_0000020 . [] oboInOwl:source "BTO", "EHDAA2", "FMA", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119380 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119382 . [] oboInOwl:notes "anterior 2/3" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119386 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119388 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119390 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget _:genid119393 . [] oboInOwl:hasDbXref "FEED:rd", "https://github.com/obophenotype/uberon/issues/256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "A muscular organ in the floor of the mouth." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000419" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/tongue" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "A mobile mass of muscular tissue that is covered with mucous membrane, occupies much of the cavity of the mouth, forms part of its floor, bears the organ of taste, and assists in chewing and swallowing. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "Muscular organ in the floor of the mouth.[FEED]" . [] oboInOwl:source "GO:0043586" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech[GO][GO:0043586]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000419" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2002.00073.x Iwasaki S, Evolution of the structure and function of the vertebrate tongue. J Anat (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "UMLS:C0040408" . [] oboInOwl:hasDbXref "Wikipedia:Tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001723 ; owl:annotatedTarget "glossus" . _:genid118837 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703, obo:UBERON_0009639 . _:genid118839 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0003129, obo:UBERON_0005902 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001724 ; owl:annotatedTarget _:genid119407 . _:genid118841 oboInOwl:hasDbXref "MESH:A04.531.621.827", "Wikipedia:Sphenoidal_sinus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001724 ; owl:annotatedTarget "One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side[MESH]. The sphenoidal sinuses (or sphenoid) contained within the body of the sphenoid vary in size and shape; owing to the lateral displacement of the intervening septum they are rarely symmetrical. The following are their average measurements: vertical height, 2.2 cm. ; transverse breadth, 2 cm. ; antero-posterior depth, 2.2 cm. [WP,unvetted]." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002241 . [] oboInOwl:source "ncithesaurus:Sphenoid_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001724 ; owl:annotatedTarget "UMLS:C0037885" . _:genid118843 oboInOwl:hasDbXref "Wikipedia:Sphenoidal_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001724 ; owl:annotatedTarget "sinus sphenoidalis" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003113 . (obo:UBERON_0002215 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003129 ] ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001725 ; owl:annotatedTarget obo:UBERON_0002215 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=87514" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001725 ; owl:annotatedTarget "The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis." . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001726 ; owl:annotatedTarget _:genid119419 . [] oboInOwl:source "BIRNLEX:4102", "ncithesaurus:Papilla_of_the_Tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001726 ; owl:annotatedTarget "UMLS:C0226964" . [] oboInOwl:source "BIRNLEX:4102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001726 ; owl:annotatedTarget "UMLS:C1289183" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget obo:UBERON_0000062 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget _:genid119424 . [] oboInOwl:source "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget _:genid119426 . _:genid118859 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget _:genid119428 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:source "http://dev.biologists.org/content/128/22/4573.full" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget _:genid119430 . _:genid118861 oboInOwl:hasDbXref "http://periowiki.wikispot.org/Taste_bud_histology" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "A specialized receptor organ that is a collection of cells spanning the gustatory epithelium." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002241 . [] oboInOwl:source "http://periowiki.wikispot.org/Taste_bud_histology" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget obo:UBERON_0002467 . _:genid118863 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010573" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "A chemoreceptive organ.[AAO]" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000130" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/taste+bud" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "One of a number of receptor cell nests located in the epithelium of the papillae of the tongue and in the soft palate, epiglottis, and pharynx that mediate the sense of taste. [TFD][VHOG]" . _:genid118865 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000130" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "Experients in amphibia have shown that an intrinsic feature of the pharyngeal endoderm is its ability to generate taste buds and this capacity must have been acquired by the endoderm at the origin of the vertebrates.[well established][VHOG]" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:source "BIRNLEX:4101", "ncithesaurus:Taste_Bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "UMLS:C0039337" . _:genid118867 oboInOwl:hasDbXref "Wikipedia:Taste_bud" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "tastebud" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009193 . [] oboInOwl:hasDbXref "Wikipedia:Taste_bud" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "caliculus gustatorius" . [] oboInOwl:hasDbXref "Wikipedia:Taste_bud" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "taste buds" . [] oboInOwl:hasDbXref "Wikipedia:Taste_bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "taste-bud" . [] oboInOwl:hasDbXref "Wikipedia:Taste_bud" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001727 ; owl:annotatedTarget "tastebuds" . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "The section of the pharynx that lies above the soft palate." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000375" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/nasopharynx" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "The uppermost of the three regions of the throat (pharynx), situated behind the nasal cavity and extending from the posterior nares to the level above the soft palate. [TFD][VHOG]" . _:genid118877 oboInOwl:source "ncithesaurus:Nasopharynx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "UMLS:C0027442" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002241 . [] oboInOwl:hasDbXref "BTO:0000662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "Nasenrachenraum" . _:genid118879 oboInOwl:hasDbXref "Wikipedia:Pharynx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "epipharynx" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "Wikipedia:Nasopharynx" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001728 ; owl:annotatedTarget "pars nasalis pharyngis" . _:genid118881 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001730 ; owl:annotatedTarget "EMAPA:37627" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001731 ; owl:annotatedTarget _:genid119459 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001731 ; owl:annotatedTarget _:genid119462 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001731 ; owl:annotatedTarget "An anatomical space that is enclosed by a pharynx." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001731 ; owl:annotatedTarget "cavitas pharyngealis" . [] oboInOwl:hasDbXref "BTO:0002097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001731 ; owl:annotatedTarget "cavitas pharyngis" . _:genid118893 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001735, obo:UBERON_0006227 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget obo:UBERON_0012330 . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002384" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget "The lymph tissue in the roof and posterior wall of the nasopharynx." . [] oboInOwl:source "ncithesaurus:Pharyngeal_Tonsil" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget "UMLS:C0001428" . [] oboInOwl:hasDbXref "FMA:54970", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget "tonsilla pharyngealis" . [] oboInOwl:hasDbXref "BTO:0000777" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget "Rachenmandel" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_tonsil" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001732 ; owl:annotatedTarget "tonsilla pharyngea" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:11931837" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget obo:UBERON_0034921 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget _:genid119476 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget _:genid119478 . [] oboInOwl:hasDbXref "GO:0060023", "UBERON:cjm", "Wikipedia:Soft_palate", "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "A muscular arch-shaped structure that is composed of the musculus uvuli and parts of tensor veli palatini, levator veli palatini, palatoglossus and palatopharyngeus and attaches to the hard palate and modulates the connections between the oral cavity and pharynx soft tissue arch .[FEED]" . _:genid118905 oboInOwl:source "ncithesaurus:Soft_Palate" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "UMLS:C0030219" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "Wikipedia:Soft_palate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "muscular palate" . [] oboInOwl:hasDbXref "Wikipedia:Soft_palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "palatum molle" . [] oboInOwl:hasDbXref "Wikipedia:Soft_palate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "velum" . _:genid118909 oboInOwl:hasDbXref "Wikipedia:Soft_palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001733 ; owl:annotatedTarget "velum palatinum" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . _:genid118911 a owl:Restriction ; owl:onProperty obo:RO_0002131, obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071625, obo:UBERON_0001697 . [] oboInOwl:hasDbXref "Wikipedia:Palatine_uvula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "Conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers." . [] oboInOwl:source "PMID:1408233" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "In a study of eight mammals a small underdeveloped uvula was found only in baboons" . [] oboInOwl:source "ncithesaurus:Uvula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "UMLS:C0042173" . [] oboInOwl:hasDbXref "FMA:55022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "uvula" . [] oboInOwl:hasDbXref "FMA:55022", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "uvula palatina" . [] oboInOwl:hasDbXref "Wikipedia:Palatine_uvula" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001734 ; owl:annotatedTarget "uvula palatina" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001735 ; owl:annotatedTarget obo:UBERON_0001961 . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001735 ; owl:annotatedTarget "The circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils." . [] oboInOwl:source "ncithesaurus:Waldeyers_Tonsillar_Ring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001735 ; owl:annotatedTarget "UMLS:C0459892" . [] oboInOwl:hasDbXref "FMA:55070", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001735 ; owl:annotatedTarget "anulus lymphoideus pharyngis" . _:genid118924 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003113, obo:UBERON_0006298 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget _:genid119501 . [] oboInOwl:hasDbXref "DOI:10.1111/j.1432-0436.2006.00088.x", "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible." . _:genid118927 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000364" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/submandibular+gland" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG]" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000364" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.525", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "In mouse, multilobed and lobulated, on the ventral midline of the neck" . [] oboInOwl:source "ncithesaurus:Submandibular_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "UMLS:C0038556" . [] oboInOwl:hasDbXref "http://www.avdc.org/Nomenclature.pdf" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "mandibular gland" . [] oboInOwl:hasDbXref "http://www.avdc.org/Nomenclature.pdf" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "mandibular salivary gland" . [] oboInOwl:hasDbXref "Wikipedia:Submandibular_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001736 ; owl:annotatedTarget "glandula submandibularis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget _:genid119514 . [] oboInOwl:hasDbXref "Wikipedia:Larynx", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget "A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget "An anatomical cluster consisting of the epiglottus, the arytenoid cartilages, the thyroid cartilage, the cricoid cartilage and the muscles, membranes, and ligaments connecting them, and also of the mucosal covering these structures.[FEED]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget obo:CL_0000164 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000268" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget "Anatomical structure consisting of a narrowly triangular chamber supported by a series of semicircular cartilages in which part of the sound-production system is located.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001279" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.239-241", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Larynx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001737 ; owl:annotatedTarget "UMLS:C0023078" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget _:genid119522 . _:genid118944 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget _:genid119524 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012072 . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "The largest of the laryngeal cartilages." . _:genid118946 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001365" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/thyroid+cartilage" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "The largest cartilage of the larynx, having two broad processes that join anteriorly to form the Adam's apple. [TFD][VHOG]" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001365" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.239-241", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "[In anura] a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) [In mammals] Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" . _:genid118948 oboInOwl:source "ncithesaurus:Thyroid_Cartilage" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "UMLS:C0040126" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0012072 . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_cartilage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "cartilago thyroidea" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget obo:CL_0000168 . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "laryngeal prominence" . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "pomus" . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001738 ; owl:annotatedTarget "pomus adamus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget obo:UBERON_0007844 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "A cell that secretes insulin and is located towards the center of the islets of Langerhans." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget _:genid119539 . [] oboInOwl:hasDbXref "MP:0002256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "The cartilaginous structures that support the larynx." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001550" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.239-241", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Laryngeal_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "UMLS:C0023050" . [] oboInOwl:hasDbXref "FMA:55108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "cartilage of larynx" . _:genid118965 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "cartilagines laryngeales" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "VHOG:0001550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001739 ; owl:annotatedTarget "larynx cartilage" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget _:genid119550 . _:genid118969 oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002257" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "The paired triangular laryngeal cartilages located postlaterally at the level of the thyroid cartilage." ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:hasDbXref "ZFA:0009102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000674" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "Paired, anteroposteriorly elongated cartilages that are associated with the vocal cords. These cartilages are medially separated and hemispherical, and their concave side faces ventromedially.[AAO]" . _:genid118971 oboInOwl:source "ncithesaurus:Arytenoid_Cartilage" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "UMLS:C0003943" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001697 . [] oboInOwl:hasDbXref "EMAPA:18695" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "arytenoid" . [] oboInOwl:hasDbXref "Wikipedia:Arytenoid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "arytenoids" . [] oboInOwl:hasDbXref "Wikipedia:Arytenoid_cartilage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "cartilagines arytenoidea" . [] oboInOwl:hasDbXref "AAO:0000674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001740 ; owl:annotatedTarget "cartilago arytaenoidea" . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "B-cell of pancreatic islet" . [] oboInOwl:hasDbXref "MP:0002259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001742 ; owl:annotatedTarget "The most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing." . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001742 ; owl:annotatedTarget "laryngeal cartilage in MP" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001742 ; owl:annotatedTarget "EMAPA:37522" . [] oboInOwl:source "ncithesaurus:Epiglottic_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001742 ; owl:annotatedTarget "UMLS:C0458526" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001743 ; owl:annotatedTarget obo:UBERON_0008845 . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell of pancreatic islet" . [] oboInOwl:hasDbXref "http://education.yahoo.com/reference/gray/subjects/subject/236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001743 ; owl:annotatedTarget "A ligament that is part of a larynx and connexts the cartilages of the larynx." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001743 ; owl:annotatedTarget "EMAPA:37626" . [] oboInOwl:source "ncithesaurus:Laryngeal_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001743 ; owl:annotatedTarget "UMLS:C0458519" . [] oboInOwl:hasDbXref "MA:0001755" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001743 ; owl:annotatedTarget "larynx ligament" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001744 ; owl:annotatedTarget obo:UBERON_0034769 . [] oboInOwl:hasDbXref "Wikipedia:Lymphoid_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001744 ; owl:annotatedTarget "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." . [] oboInOwl:source "ncithesaurus:Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001744 ; owl:annotatedTarget "UMLS:C0024296" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:12297216" . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "insulin-secreting cell" . _:genid119000 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000444 _:genid119002 ) ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003066 . _:genid119002 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003114, obo:UBERON_0010754 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001745 ; owl:annotatedTarget "A lymphoid follicle that contains a germinal center." . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic B-cell" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001746 ; owl:annotatedTarget "EMAPA:37767" . [] oboInOwl:source "ncithesaurus:Thyroid_Gland_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001746 ; owl:annotatedTarget "UMLS:C0229575" . [] oboInOwl:hasDbXref "FMA:55513", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001746 ; owl:annotatedTarget "capsula fibrosa glandulae thyroideae" . [] oboInOwl:hasDbXref "FMA:55513" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001746 ; owl:annotatedTarget "fibrous capsule of thyroid gland" . [] oboInOwl:hasDbXref "MA:0002675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001746 ; owl:annotatedTarget "thyroid gland capsule" . _:genid119018 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756, obo:UBERON_0002046 . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic beta cell" . _:genid119020 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046, obo:UBERON_0008895 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget _:genid119604 . _:genid119022 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget _:genid119606 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003099 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "A parenchyma that is part of a thyroid follicle [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "EMAPA:37769" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "parenchyma of thyroid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "parenchyma of thyroid follicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "parenchyma of thyroid gland follicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "thyroid follicle parenchyma" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "thyroid gland follicle parenchyma" . [] oboInOwl:hasDbXref "MA:0002419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "pancreatic islet core" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "thyroid parenchyma" . [] oboInOwl:hasDbXref "BTO:0004579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001747 ; owl:annotatedTarget "parenchyma glandulae thyroideae" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001748 ; owl:annotatedTarget _:genid119621 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001748 ; owl:annotatedTarget "The dense and irregular connective tissue capsule surrounding a parathyroid gland." . _:genid119039 oboInOwl:source "ncithesaurus:Parathyroid_Gland_Capsule" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001748 ; owl:annotatedTarget "UMLS:C0927176" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004368 . [] oboInOwl:hasDbXref "FMA:70586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "type B enteroendocrine cell" . (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 ] ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001749 ; owl:annotatedTarget _:genid119631 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001749 ; owl:annotatedTarget _:genid119633 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001749 ; owl:annotatedTarget "A parenchyma that is part of a parathyroid gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001749 ; owl:annotatedTarget "parathyroid parenchyma" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001749 ; owl:annotatedTarget "parenchyma of parathyroid" . [] oboInOwl:hasDbXref "MA:0002419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000169 ; owl:annotatedTarget "beta cell islet" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget _:genid119638 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget _:genid119640 . [] oboInOwl:source "HPO:pr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget _:genid119642 . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget _:genid119644 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "this is an eye appendage in ncit, along with eyelid and eyebrow. in MA, part of eye surface part_of eye" . [] oboInOwl:source "ncithesaurus:Lacrimal_Apparatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "UMLS:C0022903" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_apparatus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "apparatus lacrimalis" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "lacrymal system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "lacrimal drainage system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "nasolacrimal drainage system" . [] oboInOwl:hasDbXref "HPO:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001750 ; owl:annotatedTarget "nasolacrimal system" . _:genid119063 a owl:Restriction ; owl:onProperty obo:RO_0000086, obo:RO_0002202 ; owl:someValuesFrom obo:PATO_0002444, obo:UBERON_0007374 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget obo:UBERON_0010365 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget _:genid119657 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000069", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005143" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "Mineralized collagen containing substance that forms the tooth structure.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001589" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "Dentine is a bona fide vertebrate novelty, and dentine-secreting odontoblasts represent a cell type that is exclusively derived from the neural crest.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Dentin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "UMLS:C0011429" . [] oboInOwl:hasDbXref "MA:0002542", "ZFA:0005143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "dentin" . [] oboInOwl:hasDbXref "GO:0070468" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001751 ; owl:annotatedTarget "predentin" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget obo:UBERON_0010365 . _:genid119074 oboInOwl:source "VSAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget _:genid119667 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003107 . [] oboInOwl:proportion "85" ; oboInOwl:source "Wikipedia:ENAM" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget _:genid119669 . _:genid119076 oboInOwl:hasDbXref "Wikipedia:Enamel_organ", "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget "A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010054 . [] oboInOwl:source "PMID:19730686" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget obo:NCBITaxon_9359 . [] oboInOwl:source "PMID:19730686" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget obo:NCBITaxon_9816 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000065" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget "Skeletal tissue that consists of an avascular, noncollagenous, hypermineralized matrix that is deposited by ameloblasts that are excluded from the matrix. Enamel develops from organic pre-enamel tissue that is replaced by a largely inorganic matrix.[VSAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget "part_of tooth enamel organ in MA" . [] oboInOwl:source "ncithesaurus:Enamel" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget "UMLS:C0011350" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001752 ; owl:annotatedTarget "enamel tissue" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget obo:UBERON_0010365 . [] oboInOwl:source "PMID:19767574", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget _:genid119679 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000062", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000062" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.[VSAO]" . _:genid119087 oboInOwl:source "FMA:55630" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth[FMA:55630]." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "ncithesaurus:Cementum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "UMLS:C0011343" . [] oboInOwl:hasDbXref "FMA:55630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "cement" . [] oboInOwl:hasDbXref "VSAO:0000062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001753 ; owl:annotatedTarget "bone of attachment" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget obo:UBERON_0011825 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget _:genid119690 . [] oboInOwl:hasDbXref "Wikipedia:Dental_pulp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005141" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "Material in the center of the dentine of the mature tooth. In secondary teeth the pulp contains blood vessels and odontoblast.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001469" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature07304 Soukup V, Epperlein HH, Horacek I, Cerny R, Dual epithelial origin of vertebrate oral teeth. Nature (2008), DOI:10.1186/1471-2148-11-307 The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evolutionary Biology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "The oral cavity of vertebrates is generally thought to arise as an ectodermal invagination. Consistent with this, oral teeth are proposed to arise exclusively from ectoderm, contributing to tooth enamel epithelium, and from neural crest derived mesenchyme, contributing to dentin and pulp (reference 1); Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin (reference 2).[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Dental_Pulp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "UMLS:C0011399" . [] oboInOwl:hasDbXref "ZFA:0005141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "tooth pulp" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:12499349" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000170 ; owl:annotatedTarget "A cell that secretes glucagon." . [] oboInOwl:hasDbXref "BTO:0000339" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001754 ; owl:annotatedTarget "dental pulp cell" . [] oboInOwl:hasDbXref "GO:0042474", "Wikipedia:Middle_ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000312" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "The intermediate portion of the ear which consists of a small air-filled and membrane-lined chamber. It is lodged in the temporal bone and continues with the nasopharynx through the Eustachian tube. It is separated from the external ear by the tympanic membrane and from the inner ear by the fenestrae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000312" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[uncertain][VHOG]" . [] oboInOwl:source "BIRNLEX:1695", "ncithesaurus:Middle_Ear" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "UMLS:C0013455" . [] oboInOwl:source "BIRNLEX:1695" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "UMLS:C1268972" . [] oboInOwl:hasDbXref "BTO:0002099", "Wikipedia:Middle_ear" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001756 ; owl:annotatedTarget "auris media" . _:genid119109 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691, obo:UBERON_0002517 . [] oboInOwl:hasDbXref "Wikipedia:Pinna_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "The part of the ear that projects from the head, connecting to the external acoustic meatus." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000460" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "The external expanded part of the ear characterized by a funnel-shaped structure through which the sound vibrations are received. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000460" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.420", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "Mammals have a third type of tympanic ear. An external flap, the auricle or pinna, helps funnel sound waves down the external acoustic meatus to the tympanic membrane.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Auricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "UMLS:C0928075" . [] oboInOwl:hasDbXref "Wikipedia:Auricula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "auricula" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001757 ; owl:annotatedTarget "pinnae" . _:genid119120 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget obo:UBERON_0000479 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget _:genid119717 . _:genid119122 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget _:genid119719 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "BTO:0001021", "Wikipedia:Periodontium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO]." . _:genid119124 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "FMA treats periodontium and periodontal ligament as the same" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 . [] oboInOwl:source "ncithesaurus:Periodontium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "UMLS:C0031093" . [] oboInOwl:hasDbXref "MESH:A14.254.646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "paradentium" . [] oboInOwl:hasDbXref "FMA:56665" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "periodontal ligament" . [] oboInOwl:hasDbXref "MA:0002467" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "periodontal membrane" . [] oboInOwl:hasDbXref "MESH:A14.254.646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001758 ; owl:annotatedTarget "tooth supporting structure" . [] oboInOwl:notes "sensory" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget _:genid119734 . [] oboInOwl:notes "motor" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget _:genid119736 . [] oboInOwl:hasDbXref "ISBN:0471209627", "Wikipedia:Vagus_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010475" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "Nerve consisting of branchiomotor and visceral efferent fibers which branch and innervate the smooth muscles and glands of the heart, lungs, esophagus, and stomach as well as some throat muscles. Sensory fibers supply mucosa of the mouth and pharynx.[AAO]" . _:genid119140 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000737" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:hasDbXref "BIRNLEX:801", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "10n" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "EMAPA:37797" . [] oboInOwl:source "BIRNLEX:801", "ncithesaurus:Vagus_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "UMLS:C0042276" . [] oboInOwl:source "BIRNLEX:801" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "UMLS:C1305910" . [] oboInOwl:source "BIRNLEX:801" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "neuronames:702" . [] oboInOwl:hasDbXref "FMA:5731", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "nervus vagus [x]" . [] oboInOwl:hasDbXref "MA:0001106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "vagus X nerve" . [] oboInOwl:hasDbXref "NeuroNames:702" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "nerve X" . [] oboInOwl:hasDbXref "BTO:0003472", "Wikipedia:Vagus_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "nervus vagus" . [] oboInOwl:hasDbXref "BTO:0003472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "pneuomgastric nerve" . [] oboInOwl:hasDbXref "BAMS:10n" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001759 ; owl:annotatedTarget "vagus nerve or its root" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget obo:UBERON_0001825 . [] oboInOwl:hasDbXref "MURDOCH:753", "Wikipedia:Frontal_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget "The frontal sinus occupies the dorsal part of the skull medial to the orbit. It overlaps cranial and nasal cavities and is often referred to as the conchofrontal sinus." . _:genid119154 oboInOwl:source "MURDOCh" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget "A unique feature in the horse is that the frontal sinus communicates with the caudal maxillary sinus via the frontomaxillary opening" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005565 . [] oboInOwl:source "ncithesaurus:Frontal_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget "UMLS:C0016734" . _:genid119156 oboInOwl:hasDbXref "FMA:57417" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget "cavity of frontal bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009124 . [] oboInOwl:hasDbXref "Wikipedia:Frontal_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001760 ; owl:annotatedTarget "sinus frontales" . _:genid119158 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005856 _:genid119160 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0007003 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010258 . _:genid119160 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008281, obo:UBERON_0012175 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget _:genid119766 . [] oboInOwl:hasDbXref "Wikipedia:Dental_papilla", "ZFA:0005140" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "A condensation of odontoblasts that forms the part of a tooth germ that gives rise to dentin and pulp in the mature tooth. It lies below a cellular aggregation known as the enamel organ." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000025" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "Cell condensation that is a well-defined population of densely organized mesenchymal cells that aggregates adjacent to an epithelium.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005140" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "Tissue of the developing tooth. It is composed of pre-odontoblast and undiffentiated mesnchyme cells and connects to the basal lamina.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001465" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1186/1471-2148-11-307 The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evolutionary Biology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VSAO:0000025" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "odontogenic condensation" . [] oboInOwl:hasDbXref "ZFA:0005140" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "pharyngeal tooth mesenchyme" . [] oboInOwl:hasDbXref "MA:0001598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "dental papilla" . [] oboInOwl:hasDbXref "BTO:0001839" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "dentinal papilla" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "dermal papilla" . [] oboInOwl:hasDbXref "Wikipedia:Dental_papilla" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "papilla dentis" . [] oboInOwl:hasDbXref "ZFA:0005140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001763 ; owl:annotatedTarget "tooth mesenchyme" . [] oboInOwl:hasDbXref "MESH:A04.531.621.578", "Wikipedia:Maxillary_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001764 ; owl:annotatedTarget "One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000171 ; owl:annotatedTarget "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." . _:genid119180 oboInOwl:source "ncithesaurus:Maxillary_Sinus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001764 ; owl:annotatedTarget "UMLS:C0024957" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005491 . [] oboInOwl:hasDbXref "Wikipedia:Maxillary_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001764 ; owl:annotatedTarget "sinus maxilliaris" . _:genid119182 oboInOwl:hasDbXref "MESH:A04.531.621.578" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001764 ; owl:annotatedTarget "Highmore antrum" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0009125 . [] oboInOwl:hasDbXref "MESH:A04.531.621.578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001764 ; owl:annotatedTarget "maxillary antrum" . [] oboInOwl:hasDbXref "GO:0060603", "Wikipedia:Lactiferous_duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "Epithelial tube that transports milk[GO]." . [] oboInOwl:source "ncithesaurus:Lactiferous_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "UMLS:C0222613" . [] oboInOwl:hasDbXref "FMA:58006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "lactiferous duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "lactiferous gland duct" . [] oboInOwl:hasDbXref "MA:0000791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "mammary gland duct" . [] oboInOwl:hasDbXref "BTO:0002845", "Wikipedia:Lactiferous_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "ductus lactiferi" . [] oboInOwl:hasDbXref "Wikipedia:Lactiferous_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "galactophorous duct" . [] oboInOwl:hasDbXref "BTO:0002845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "galactophorous tubule" . [] oboInOwl:hasDbXref "BTO:0002845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "lactiferous tubule" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:12834252" . [] oboInOwl:hasDbXref "Wikipedia:Lactiferous_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001765 ; owl:annotatedTarget "mammilary duct" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget obo:UBERON_0006311 . [] oboInOwl:hasDbXref "MESH:A09.371.060.067", "MP:0005205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001431" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/anterior+chamber" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" . _:genid119207 oboInOwl:source "ncithesaurus:Anterior_Chamber_of_the_Eye" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "UMLS:C0003151" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . [] oboInOwl:hasDbXref "HP:0000593", "MP:0010709" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "anterior chamber" . _:genid119209 oboInOwl:hasDbXref "BTO:0002084" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "camera anterior bulbi" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011272 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_chamber_of_eyeball" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "camera anterior bulbi oculi" . [] oboInOwl:hasDbXref "BTO:0002084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001766 ; owl:annotatedTarget "camera oculi anterior" . _:genid119217 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget obo:UBERON_0004923 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006813 . [] oboInOwl:hasDbXref "MP:0005197", "Wikipedia:Uvea" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." . _:genid119219 oboInOwl:source "ncithesaurus:Uvea" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "UMLS:C0042160" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011241 . [] oboInOwl:hasDbXref "FMA:58103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "tunica vasculosa of eyeball" . _:genid119221 oboInOwl:hasDbXref "FMA:58103" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "uvea" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009714 . [] oboInOwl:hasDbXref "FMA:58103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "uveal tract" . [] oboInOwl:hasDbXref "Wikipedia:Uvea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "pars iridica retinae" . [] oboInOwl:hasDbXref "Wikipedia:Uvea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "tunica vasculatis oculi" . [] oboInOwl:hasDbXref "Wikipedia:Uvea" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "tunica vasculosa bulbi" . [] oboInOwl:hasDbXref "FMA:58103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001768 ; owl:annotatedTarget "vascular layer of eyeball" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget _:genid119830 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001322" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000101" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000101" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Iris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "UMLS:C0022077" . _:genid119234 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "irides" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015788 . [] oboInOwl:hasDbXref "VHOG:0000101" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001769 ; owl:annotatedTarget "irises" . [] oboInOwl:source "AAO", "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget obo:UBERON_0000464 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget "The central circular aperture of the iris through which light rays enter the eye." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000116" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget "The circular orifice in the centre of the iris, through which light enters into the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000116" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pupil" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget "UMLS:C0034121" . [] oboInOwl:hasDbXref "ZFA:0001283" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001771 ; owl:annotatedTarget "pupils" . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget _:genid119851 . [] oboInOwl:hasDbXref "MESH:A09.371.060.217.325", "MGI:smb", "MP:0006000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "The smooth stratified squamous epithelium that covers the outer surface of the cornea." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002187" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-061010-3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" . [] oboInOwl:source "ncithesaurus:Corneal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "UMLS:C0459875" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "cornea epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "cornea epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "epithelial tissue of cornea" . [] oboInOwl:hasDbXref "FMA:58263", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "epithelium anterius corneae" . _:genid119257 oboInOwl:hasDbXref "BTO:0000287" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "anterior endothelium of cornea" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:hasDbXref "Wikipedia:Corneal_epithelium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "e. anterius corneae" . [] oboInOwl:hasDbXref "BTO:0000287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "endothelium anterius corneae" . [] oboInOwl:hasDbXref "BTO:0000287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "endothelium camerae anterioris bulbi" . [] oboInOwl:hasDbXref "BTO:0000287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "endothelium corneale" . _:genid119262 oboInOwl:hasDbXref "BTO:0000287" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001772 ; owl:annotatedTarget "epithelium posterius corneae" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget _:genid119867 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget _:genid119869 . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget _:genid119872 . [] oboInOwl:inferred_by "cjm" ; oboInOwl:source "ISBN:0781772214", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget _:genid119874 . [] oboInOwl:hasDbXref "Wikipedia:Sclera", "ZFIN:ZDB-PUB-050701-15" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." . [] oboInOwl:source "Wikipedia:Sclera" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001274" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/sclera" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Sclera" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001773 ; owl:annotatedTarget "UMLS:C0036410" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget _:genid119885 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "A skeletal muscle organ that is part of the trunk region." . [] oboInOwl:hasDbXref "ZFA:0000473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "body musculature" . [] oboInOwl:hasDbXref "FMA:58274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "muscle of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "muscle organ of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "muscle organ of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "torso muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001774 ; owl:annotatedTarget "trunk muscle organ" . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget _:genid119897 . [] oboInOwl:hasDbXref "FMA:0517223651", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000173 ; owl:annotatedTarget "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005099", "Wikipedia:Ciliary_body" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000102" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" . _:genid119292 oboInOwl:source "ncithesaurus:Ciliary_Body" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget "UMLS:C0008779" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005867 . [] oboInOwl:hasDbXref "VHOG:0000102" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget "ciliary bodies" . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_body" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001775 ; owl:annotatedTarget "corpus ciliare" . _:genid119299 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000019, obo:UBERON_0001768 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:14992292" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget _:genid119905 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget _:genid119908 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget obo:UBERON_0011892 . [] oboInOwl:hasDbXref "Wikipedia:Choroid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "MP treats posterior uvea and optic choroid as distinct" . [] oboInOwl:source "ncithesaurus:Choroid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "UMLS:C0008520" . [] oboInOwl:hasDbXref "MA:0000263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "choroid" . [] oboInOwl:hasDbXref "Wikipedia:Choroid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "choroid coat" . [] oboInOwl:hasDbXref "Wikipedia:Choroid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "choroidea" . [] oboInOwl:hasDbXref "VHOG:0001568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "eye choroid" . [] oboInOwl:hasDbXref "Wikipedia:Uvea#Regions" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "posterior uvea" . [] oboInOwl:hasDbXref "BTO:0001829" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "chorioid" . [] oboInOwl:hasDbXref "Wikipedia:Choroid" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "choroidea" . [] oboInOwl:hasDbXref "ZFA:0005229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001776 ; owl:annotatedTarget "optic choroid" . [] oboInOwl:inferred_by "cjm" ; oboInOwl:source "ISBN:0781772214", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget _:genid119930 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MESH:A09.371.060.217.228", "MP:0005300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002189" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-061010-3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002189" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002189" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" . [] oboInOwl:source "ncithesaurus:Corneal_Stroma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "UMLS:C0010040" . [] oboInOwl:hasDbXref "MA:0001245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "corneal stroma" . [] oboInOwl:hasDbXref "FMA:58306", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001777 ; owl:annotatedTarget "substantia propria corneae" . _:genid119329 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001943 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget obo:UBERON_0000488 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget _:genid119947 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget _:genid119949 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget _:genid119951 . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_body#Ciliary_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget "A double layer covering the ciliary body that produces aqueous humor." . [] oboInOwl:source "ncithesaurus:Ciliary_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget "UMLS:C0459736" . [] oboInOwl:hasDbXref "FMA:58464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget "ciliary body epithelium" . [] oboInOwl:hasDbXref "FMA:58464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001778 ; owl:annotatedTarget "epithelium of ciliary body" . [] oboInOwl:hasDbXref "Wikipedia:Iris_stroma", "http://www.drugs.com/dict/stroma-of-iris.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001779 ; owl:annotatedTarget "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." . [] oboInOwl:hasDbXref "MESH:A08.800.800.720", "MP:0001077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000824" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/spinal+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Spinal_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "UMLS:C0037941" . _:genid119355 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "backbone nerve" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "nerve of backbone" . _:genid119357 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "nerve of spinal column" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "nerve of spine" . _:genid119359 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "nerve of vertebral column" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005619 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "spinal column nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "spine nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "vertebral column nerve" . [] oboInOwl:hasDbXref "Wikipedia:Spinal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "nervi spinales" . [] oboInOwl:hasDbXref "BAMS:spin" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001780 ; owl:annotatedTarget "spinal nerves" . [] oboInOwl:hasDbXref "MP:0003727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001781 ; owl:annotatedTarget "Any of the layers that make up the retina[MP]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001781 ; owl:annotatedTarget "MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers" . [] oboInOwl:source "ncithesaurus:Retina_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001781 ; owl:annotatedTarget "UMLS:C0459649" . [] oboInOwl:hasDbXref "MP:0006069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001781 ; owl:annotatedTarget "retina neuronal layer" . [] oboInOwl:hasDbXref "MP:0006069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001781 ; owl:annotatedTarget "retinal neuronal layer" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget _:genid119993 . [] oboInOwl:hasDbXref "Wikipedia:Retinal_pigment_epithelium", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." . _:genid119380 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000144" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011096" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ZFA:0000144" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "The monolayer of pigmented epithelium covering the neural retina.[AAO]" . _:genid119382 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000536" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 . [] oboInOwl:source "ncithesaurus:Retinal_Pigment_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "UMLS:C0035322" . [] oboInOwl:hasDbXref "MP:0005201", "Wikipedia:Retinal_pigment_epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "retinal pigment epithelium" . [] oboInOwl:hasDbXref "ZFA:0000144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "retinal pigmented epithelium" . _:genid119386 oboInOwl:hasDbXref "FMA:58627", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "stratum pigmentosum retinae" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0006260 . [] oboInOwl:hasDbXref "BTO:0001177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "epithelium, retinal pigment" . _:genid119388 oboInOwl:hasDbXref "Wikipedia:Retinal_pigment_epithelium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "p. pigmentosa retinae" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0006756 . [] oboInOwl:hasDbXref "VHOG:0000536" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "retinal pigment layer" . _:genid119390 oboInOwl:hasDbXref "Wikipedia:Retinal_pigment_epithelium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001782 ; owl:annotatedTarget "stratum pigmentosa retinae" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0006757 . _:genid119393 oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "The optic disc or optic nerve head is the location where ganglion cell axons exit the eye to form the optic nerve. There are no light sensitive rods or cones to respond to a light stimulus at this point. This causes a break in the visual field called 'the blind spot' or the 'physiological blind spot'. The optic nerve head in a normal human eye carries from 1 to 1.2 million neurons from the eye towards the brain. [WP,unvetted]." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010056 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000551" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/optic+disc" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "The small blind spot on the surface of the retina. It is the point where the fibers of the retina leave the eye and become part of the optic nerve. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000551" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod (reference 2).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Optic_Disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "UMLS:C0029127" . [] oboInOwl:hasDbXref "MESH:A08.800.800.120.680.660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "optic disk" . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "optic disk" . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "optic nerve disc" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:15503229" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12050120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000178 ; owl:annotatedTarget "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "optic nerve head" . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "optic papilla" . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "physiologic blind spot" . [] oboInOwl:hasDbXref "Wikipedia:Optic_disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001783 ; owl:annotatedTarget "physiologic blind spot of mariotte" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Cranial_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000641" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000279" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1623", "ncithesaurus:Cranial_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "UMLS:C0010268" . [] oboInOwl:source "BIRNLEX:1623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "UMLS:C1269897" . [] oboInOwl:hasDbXref "Wikipedia:Cranial_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001785 ; owl:annotatedTarget "nervus cranialis" . _:genid119419 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_27547, obo:UBERON_0009471 . [] oboInOwl:hasDbXref "Wikipedia:Fovea", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001572" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/fovea" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "A small pit in the center of the macula lutea, the area of clearest vision, where the retinal layers are spread aside, and light falls directly on the cones. [TFD][VHOG]" . _:genid119424 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001572" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S095252380623342X Ahnelt PK, Schubert C, Kübber-Heiss A, Schiviz A, Anger E, Independent variation of retinal S and M cone photoreceptor topographies: A survey of four families of mammals. Visual neuroscience (2006), http://www.ncbi.nlm.nih.gov/pubmed/11193946 Azuma N, Molecular cell biology on morphogenesis of the fovea and evolution of the central vision. Nihon Ganka Gakkai Zasshi (2000), DOI:10.1016/S1350-9462(00)00012-4 Ahnelt PK, Kolb H, The mammalian photoreceptor mosaic-adaptive design. Progress in Retinal and Eye Research (2000)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "Definition of fovea centralis should be considered here as 'an area centralis at the visual axis' (reference 1). There is an uncertaincy of the relation, because: 1.-The fovea first appeared in evolution in the temporal retina of fishes. Then, in birds, the nasal fovea and bifoveal system with nasal and temporal foveas developed. The fovea disappeared in primitive mammals, and reappeared in primates. A residue of the fovea is conserved in the visual streak, and the disappearance and reappearance of the fovea, in primitive mammals and primates respectively, correlates with degeneration and restoration of cone pigment genes in photoreceptors (reference 2). 2.-Many retinal features (foveas, trichromacy, midget pathways and associated cell types) appear specific to primates. This has led to investigations in parallel with other mammalian models such as cat or rabbit. Correlation of the results often proves to be difficult, since an evolutionary scenario with transitions between the mammalian models is largely lacking (reference 3).[uncertain][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001033 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "EMAPA:37589" . _:genid119426 oboInOwl:source "BIRNLEX:2543", "ncithesaurus:Fovea_Centralis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "UMLS:C0016622" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002926 . [] oboInOwl:source "BIRNLEX:2543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "UMLS:C0450290" . _:genid119428 oboInOwl:hasDbXref "BIRNLEX:2543" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "centre of macula" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000209 . [] oboInOwl:hasDbXref "Wikipedia:Fovea_centralis_in_macula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "fovea centralis in macula" . _:genid119430 oboInOwl:hasDbXref "BIRNLEX:2543" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001786 ; owl:annotatedTarget "centre of fovea" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget _:genid120049 . [] oboInOwl:hasDbXref "Wikipedia:Layer_of_rods_and_cones", "ZFA:0000143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "The layer within the retina where the photoreceptor cell receptor segments reside." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001165" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "we follow MA and ZFA in subdividing this into inner and outer segments" . [] oboInOwl:source "ncithesaurus:Layer_of_the_Rods_and_Cones" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "UMLS:C0229206" . [] oboInOwl:hasDbXref "ZFA:0000143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "retinal photoreceptor layer" . [] oboInOwl:hasDbXref "FMA:58680", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "stratum segmentorum externorum et internorum retinae" . [] oboInOwl:hasDbXref "ZFA:0000143" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001787 ; owl:annotatedTarget "retinal photoreceptor layers" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget obo:UBERON_0007619 . [] oboInOwl:hasDbXref "MP:0010236", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "The row of jucntional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier[MP]." . [] oboInOwl:source "ncithesaurus:Outer_Limiting_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "UMLS:C1518685" . [] oboInOwl:hasDbXref "ZFA:0001331" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "external limiting membrane" . [] oboInOwl:hasDbXref "XAO:0003224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "outer limiting membrane" . [] oboInOwl:hasDbXref "MP:0010236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "retina outer limiting membrane" . [] oboInOwl:hasDbXref "FMA:58683", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "stratum limitans externum retinae" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "BRB" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "blood retina barrier" . [] oboInOwl:hasDbXref "ZFA:0001331" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001788 ; owl:annotatedTarget "outer limiting membranes" . [] oboInOwl:notes "soma" ; oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget _:genid120072 . [] oboInOwl:hasDbXref "ZFA:0001464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "The layer within the retina where the photoreceptor cell bodies reside." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001170" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . _:genid119459 oboInOwl:source "ncithesaurus:Outer_Nuclear_Layer_of_Retina" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "UMLS:C0229210" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "MESH:D022781", "PMID:19717280", "http://en.wikipedia.org/wiki/Hepatocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000182 ; owl:annotatedTarget "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." . [] oboInOwl:hasDbXref "EMAPA:19157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "neural retina outer nuclear layer" . [] oboInOwl:hasDbXref "FMA:58684", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "stratum nucleare externum retinae" . _:genid119462 oboInOwl:hasDbXref "BTO:0005600" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "external nuclear layer" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 . [] oboInOwl:hasDbXref "BTO:0005600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "layer of outer granules" . [] oboInOwl:hasDbXref "BAMS:Ronl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "retina, outer nuclear layer" . [] oboInOwl:hasDbXref "ZFA:0001464" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001789 ; owl:annotatedTarget "retinal outer nuclear layers" . [] oboInOwl:hasDbXref "ZFA:0001330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "The layer within the retina where the bipolar cells synapse with the photoreceptor cells[ZFA]. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells[GO]." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000183 ; owl:annotatedTarget "A cell whose primary function is to shorten." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001330" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "The layer within the retina where the bipolar cells synapse with the photoreceptor cells.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001171" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:hasDbXref "BTO:0003174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "external plexiform layer" . [] oboInOwl:source "ncithesaurus:Outer_Plexiform_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "UMLS:C0229217" . [] oboInOwl:hasDbXref "BTO:0003174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "outer plexiform layer" . [] oboInOwl:hasDbXref "FMA:58685", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "stratum plexiforme externum retinae" . _:genid119476 oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "OPL" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 . [] oboInOwl:hasDbXref "BAMS:Ropl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "retina, outer plexiform layer" . _:genid119478 oboInOwl:hasDbXref "ZFA:0001330" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001790 ; owl:annotatedTarget "retinal outer plexiform layers" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001716 . [] oboInOwl:hasDbXref "NLX:93816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia)." . [] oboInOwl:source "BTO:0003176" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "The layer of the retina composed of the cell bodies of bipolar cells, horizontal cells, and some of the cell bodies of amacrine cells[BTO:0003176]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001167" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Inner_Nuclear_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "UMLS:C0229211" . [] oboInOwl:hasDbXref "ZFA:0000119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "intermediate cell layer" . [] oboInOwl:hasDbXref "MESH:D032342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000187 ; owl:annotatedTarget "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." . [] oboInOwl:hasDbXref "EMAPA:19155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "neural retina inner nuclear layer" . [] oboInOwl:hasDbXref "FMA:58686", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "stratum nucleare internum retinae" . [] oboInOwl:hasDbXref "NLX:93816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "layer of inner granules" . [] oboInOwl:hasDbXref "BAMS:Rinl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001791 ; owl:annotatedTarget "retina, inner nuclear layer" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget obo:UBERON_0001781 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget _:genid120114 . [] oboInOwl:hasDbXref "NLX:36500" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:15780050" . [] oboInOwl:source "Wikipedia:Ganglion_cell_layer" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." . _:genid119501 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001166" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001710 . [] oboInOwl:external_ontology "NIF" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" . [] oboInOwl:hasDbXref "FMA:58687", "ZFA:0000024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "ganglion cell layer" . [] oboInOwl:hasDbXref "FMA:58687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "ganglionic cell layer of retina" . [] oboInOwl:hasDbXref "MP:0008510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "retinal ganglion layer" . [] oboInOwl:hasDbXref "FMA:58687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "stratum ganglionicum (retina)" . [] oboInOwl:hasDbXref "BAMS:Rgcl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "retina, ganglion cell layer" . [] oboInOwl:hasDbXref "Wikipedia:Ganglion_cell_layer" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001792 ; owl:annotatedTarget "stratum ganglionicum retinae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget _:genid120129 . _:genid119514 oboInOwl:hasDbXref "ISBN:0-914294-08-3", "MGI:smb" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "Layer of the retina formed by expansion of the fibers of the optic nerve." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008947 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001169" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "nerve fiber layer" . [] oboInOwl:hasDbXref "DMBA:15652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "optic fiber layer" . [] oboInOwl:hasDbXref "FMA:58688", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "stratum neurofibrarum retinae" . [] oboInOwl:hasDbXref "EMAPA:18591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "neural retina nerve fibre layer" . [] oboInOwl:hasDbXref "VHOG:0001169" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "optic fiber layer" . [] oboInOwl:hasDbXref "TAO:0002212" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "optic fiber layers" . _:genid119522 oboInOwl:hasDbXref "Wikipedia:Nerve_fiber_layer" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001793 ; owl:annotatedTarget "stratum neurofibrum retinae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010212 . _:genid119524 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:GO_0043005, obo:UBERON_0010219 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget obo:UBERON_0007619 . [] oboInOwl:hasDbXref "MP:0010235" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "The row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous[MP]." . [] oboInOwl:source "ZFIN:ZDB-PUB-071023-7, ZFIN:ZDB-PUB-120529-3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "Membrane on the apical surface of the retina. The retinal vasculature becomes adhered to the apical surface of the ILM by 30dpf[ZFIN:ZDB-PUB-071023-7, ZFIN:ZDB-PUB-120529-3]." . [] oboInOwl:hasDbXref "ZFA:0001029" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "ILM" . [] oboInOwl:source "ncithesaurus:Inner_Limiting_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "UMLS:C1512783" . [] oboInOwl:hasDbXref "XAO:0003222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "inner limiting membrane" . [] oboInOwl:hasDbXref "MP:0010235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "retina inner limiting membrane" . [] oboInOwl:hasDbXref "FMA:58689", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "stratum limitans internum retinae" . [] oboInOwl:hasDbXref "ZFA:0001029" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001794 ; owl:annotatedTarget "inner limiting membranes" . _:genid119539 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001791, obo:UBERON_0008895 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000188 ; owl:annotatedTarget "A somatic cell located in skeletal muscle." . [] oboInOwl:hasDbXref "NLX:20558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "Cytoarchitectural layer of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer (adapted from Wikipedia)." . [] oboInOwl:source "GO:0010842" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842]." . _:genid119550 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001329" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "The layer within the retina where the bipolar cells synapse with the dendrites of the ganglion cells.[TAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010220 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001168" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Inner_Plexiform_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "UMLS:C0229221" . [] oboInOwl:hasDbXref "FMA:58704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "stratum plexiforme internum" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "IPL" . [] oboInOwl:hasDbXref "BTO:0003175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "inner plexiform layer" . [] oboInOwl:hasDbXref "NLXANAT:1005032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "internal plexiform layer of retina" . [] oboInOwl:hasDbXref "BAMS:Ripl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "retina, inner plexiform layer" . [] oboInOwl:hasDbXref "NLXANAT:1005032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "retinal internal plexiform layer" . [] oboInOwl:hasDbXref "BTO:0003175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "stratum plexifome internum" . [] oboInOwl:hasDbXref "MESH:D032389", "PMID:9315361", "http://en.wikipedia.org/wiki/Smooth_muscle_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." . [] oboInOwl:hasDbXref "Wikipedia:Inner_plexiform_layer" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001795 ; owl:annotatedTarget "stratum plexiforme internum retinae" . [] oboInOwl:notes "FMA def states A and P", "located_in in EHDAA2" ; oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget _:genid120182 . [] oboInOwl:hasDbXref "Wikipedia:Aqueous_humor" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000548" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/aqueous+humour" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000548" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." . [] oboInOwl:source "ncithesaurus:Aqueous_Humor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "UMLS:C0003662" . [] oboInOwl:hasDbXref "EHDAA2:0000139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "aqueous humour" . [] oboInOwl:hasDbXref "PMID:9315361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "SMCs" . [] oboInOwl:hasDbXref "FMA:58819", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001796 ; owl:annotatedTarget "humor aquosus" . [] oboInOwl:hasDbXref "MP:0002699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." . [] oboInOwl:hasDbXref "FMA:67388" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "portion of vitreous humor" . [] oboInOwl:source "ncithesaurus:Vitreous_Humor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "UMLS:C0229096" . [] oboInOwl:hasDbXref "FMA:58822", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "humor vitreus" . [] oboInOwl:hasDbXref "ZFA:0005561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "vitreous" . [] oboInOwl:hasDbXref "FMA:58822" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "whole portion of vitreous humor" . [] oboInOwl:hasDbXref "MESH:D032389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000192 ; owl:annotatedTarget "myocytes, smooth muscle" . [] oboInOwl:hasDbXref "BTO:0001451" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "humoral fluid" . [] oboInOwl:hasDbXref "BTO:0001451" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "ocular fluid" . [] oboInOwl:hasDbXref "BTO:0001451" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001797 ; owl:annotatedTarget "vitreous fluid" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001798 ; owl:annotatedTarget obo:UBERON_0011825 . [] oboInOwl:notes "neural ectoderm of optic cup" ; oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001798 ; owl:annotatedTarget _:genid120207 . [] oboInOwl:hasDbXref "MP:0002699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001798 ; owl:annotatedTarget "Gelatinous mucoid tissue that is composed of vitreous humor and fills the cavity behind the crystalline lens of the eye and in front of the retina[MP,modified]." . [] oboInOwl:source "ncithesaurus:Vitreous_Body" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001798 ; owl:annotatedTarget "UMLS:C0042905" . [] oboInOwl:hasDbXref "BTO:0002087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball[BTO,modified]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "EMAPA:37805" . [] oboInOwl:source "ncithesaurus:Vitreous_Chamber" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "UMLS:C0229095" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "camera postrema" . [] oboInOwl:hasDbXref "FMA:58848", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "camera postrema bulbi oculi" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "camera vitrea" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:15911239" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "camera vitrea bulbi" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "postremal chamber" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "postremal chamber of eyeball" . [] oboInOwl:hasDbXref "FMA:58848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001799 ; owl:annotatedTarget "vitreous chamber" . _:genid119604 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000045 _:genid119606 ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000570 . _:genid119606 a owl:Restriction ; owl:onProperty obo:BFO_0000051, core:extends_fibers_into ; owl:someValuesFrom obo:CL_0002258, obo:UBERON_0001027 . [] oboInOwl:hasDbXref "MP:0000960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001800 ; owl:annotatedTarget "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." . [] oboInOwl:source "ncithesaurus:Sensory_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001800 ; owl:annotatedTarget "UMLS:C0206429" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001800 ; owl:annotatedTarget "ganglion sensorium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget _:genid120234 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget _:genid120236 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget obo:UBERON_0001802 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MESH:A09.371.060", "MP:0005193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget obo:UBERON_0001802 . [] oboInOwl:source "ncithesaurus:Anterior_Eye_Segment" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget "UMLS:C0003153" . [] oboInOwl:hasDbXref "ZFA:0005566" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget "anterior segment eye" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_segment_of_eyeball" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001801 ; owl:annotatedTarget "segmentum anterius bulbi oculi" . _:genid119621 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget _:genid120245 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001132 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget _:genid120247 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005195" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." . [] oboInOwl:source "ncithesaurus:Posterior_Eye_Segment" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget "UMLS:C0278450" . [] oboInOwl:hasDbXref "ZFA:0005567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget "posterior segment eye" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_segment_of_eyeball" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001802 ; owl:annotatedTarget "segmentum posterius bulbi oculi" . _:genid119631 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000446, obo:UBERON_0000965 . _:genid119633 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "A layer of epithelial cells that is part of the eye." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002199 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "epithelial tissue of eye lens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "epithelial tissue of lens" . [] oboInOwl:hasDbXref "FMA:58871", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "epithelium lentis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "epithelium of eye lens" . _:genid119638 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "eye lens epithelial tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "eye lens epithelium" . _:genid119640 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001803 ; owl:annotatedTarget "lens epithelial tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010409 . (obo:UBERON_0000476 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000965 ] ) . ( ) . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget _:genid120275 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget _:genid120277 . [] oboInOwl:hasDbXref "MGI:smb", "MP:0003236", "PMID:15483628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "The elastic, clear, membrane-like structure, that is outer most layer of the lens." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000550" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000550" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular" . [] oboInOwl:source "ncithesaurus:Lens_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "UMLS:C0229232" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001804 ; owl:annotatedTarget "capsula lentis" . (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002410 ] ) . [] oboInOwl:hasDbXref "Wikipedia:Autonomic_ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." . [] oboInOwl:source "ncithesaurus:Autonomic_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "UMLS:C0017068" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "autonomic nervous system ganglion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "ganglion of autonomic nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "ganglion of visceral nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "visceral nervous system ganglion" . _:genid119667 oboInOwl:hasDbXref "Wikipedia:Autonomic_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001805 ; owl:annotatedTarget "ganglion autonomicum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011588 . (obo:UBERON_0000045 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000013 ] ) . [] oboInOwl:source "DOI:10.1101/gr.157586.113", "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget _:genid120301 . [] oboInOwl:hasDbXref "MP:0001008", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." . [] oboInOwl:source "ncithesaurus:Sympathetic_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "UMLS:C0017071" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "ganglion of sympathetic nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "ganglion of sympathetic part of autonomic division of nervous system" . _:genid119679 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "sympathetic nervous system ganglion" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0008969 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "sympathetic part of autonomic division of nervous system ganglion" . [] oboInOwl:hasDbXref "BTO:0001333", "Wikipedia:Sympathetic_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001806 ; owl:annotatedTarget "ganglion sympathicum" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001808 ; owl:annotatedTarget _:genid120316 . [] oboInOwl:hasDbXref "NLXANAT:100303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001808 ; owl:annotatedTarget "Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands." . [] oboInOwl:hasDbXref "MESH:D008465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000199 ; owl:annotatedTarget "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." . _:genid119690 oboInOwl:source "ncithesaurus:Parasympathetic_Ganglion" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001808 ; owl:annotatedTarget "UMLS:C0017069" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001763 . [] oboInOwl:hasDbXref "BTO:0001256", "Wikipedia:Parasympathetic_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001808 ; owl:annotatedTarget "ganglion parasympathicum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001809 ; owl:annotatedTarget obo:UBERON_0001808 . [] oboInOwl:hasDbXref "Wikipedia:Enteric_ganglia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001809 ; owl:annotatedTarget "." . [] oboInOwl:source "ncithesaurus:Enteric_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001809 ; owl:annotatedTarget "UMLS:C0501399" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:16169526" . [] oboInOwl:hasDbXref "MP:0000972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000199 ; owl:annotatedTarget "mechanoreceptor" . [] oboInOwl:hasDbXref "FMA:5896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001809 ; owl:annotatedTarget "intramural ganglion" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget _:genid120333 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget _:genid120335 . [] oboInOwl:hasDbXref "FMA:5901", "Wikipedia:Nervous_system_plexus", "https://github.com/obophenotype/cell-ontology/issues/1306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget "Made to be a subtype of junction rather than tissue to be consistent with FMA" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget "EMAPA:37683" . [] oboInOwl:source "ncithesaurus:Nerve_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001810 ; owl:annotatedTarget "UMLS:C0501403" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget _:genid120342 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget _:genid120344 . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget _:genid120346 . [] oboInOwl:hasDbXref "MESH:A09.371.060.200", "MGI:csmith", "MP:0001310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." . [] oboInOwl:source "ncithesaurus:Conjunctiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "UMLS:C0009758" . _:genid119717 oboInOwl:hasDbXref "XAO:0000182" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "conjunctivae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003672 . [] oboInOwl:hasDbXref "XAO:0000182" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "conjunctivas" . _:genid119719 oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "tunica conjunctiva" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002166 . [] oboInOwl:hasDbXref "FMA:59011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001811 ; owl:annotatedTarget "wall of conjunctival sac" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget obo:UBERON_0010305 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget _:genid120358 . [] oboInOwl:hasDbXref "MP:0013394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget "A thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies." . [] oboInOwl:source "ncithesaurus:Palpebral_Conjunctiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget "UMLS:C0229274" . [] oboInOwl:hasDbXref "MP:0013394" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget "conjunctival layer of eyelids" . [] oboInOwl:hasDbXref "Wikipedia:Conjunctiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001812 ; owl:annotatedTarget "tarsal conjunctiva" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=70024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "An intermingling of fiber fascicles from adjacent spinal nerves to form a network." . _:genid119734 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000926" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.436", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "ncithesaurus:Spinal_Nerve_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "UMLS:C0228603" . _:genid119736 oboInOwl:hasDbXref "FMA:5903", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "plexus nervorum spinalium" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005239 . [] oboInOwl:hasDbXref "FMA:5903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "plexus of spinal nerves" . [] oboInOwl:hasDbXref "FMA:5903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "somatic nerve plexus" . [] oboInOwl:hasDbXref "FMA:5903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001813 ; owl:annotatedTarget "spinal nerve plexus" . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Brachial_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000372" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/brachial+plexus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "A nerve plexus originating from the anterior branches of the last four cervical and the first thoracic spinal nerves, giving off many of the principal nerves of the shoulder, chest, and arms. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000372" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.436", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Brachial_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "UMLS:C0006090" . [] oboInOwl:hasDbXref "MA:0001180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "brachial plexus" . [] oboInOwl:hasDbXref "Wikipedia:Brachial_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001814 ; owl:annotatedTarget "plexus brachialis" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001815 ; owl:annotatedTarget "An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle." . [] oboInOwl:source "ncithesaurus:Lumbosacral_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001815 ; owl:annotatedTarget "UMLS:C0024093" . [] oboInOwl:hasDbXref "FMA:5907", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001815 ; owl:annotatedTarget "plexus lumbosacralis" . [] oboInOwl:hasDbXref "Wikipedia:Lumbosacral_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001815 ; owl:annotatedTarget "plexus lumbosacralis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001816 ; owl:annotatedTarget "A nerve plexus that is part of an autonomic nervous system [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:5910", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001816 ; owl:annotatedTarget "plexus autonomicus" . [] oboInOwl:hasDbXref "FMA:5910", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001816 ; owl:annotatedTarget "plexus nervosus visceralis" . [] oboInOwl:hasDbXref "FMA:5910", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001816 ; owl:annotatedTarget "plexus visceralis" . _:genid119766 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001750, obo:UBERON_0003856 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_gland", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP]." . [] oboInOwl:source "FMA:59101" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "Lobular organ the parenchyma of which consists of glandular acini which communicate the lacrimal sac. Examples: There only two instances, right lacrimal and left lacrimal glands." . [] oboInOwl:source "Wikipedia:Preorbital_gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "The preorbital gland is a paired exocrine gland found in many species of hoofed animals, which is homologous to the lacrimal gland found in humans. These glands are trenchlike slits of dark blue to black, nearly bare skin extending from the medial canthus of each eye. They are lined by a combination of sebaceous and sudoriferous glands, and they produce secretions which contain pheromones and other semiochemical compounds. Ungulates frequently deposit these secretions on twigs and grass as a means of communication with other animals. The preorbital gland serves different roles in different species. Pheromone-containing secretions from the preorbital gland may serve to establish an animal's dominance (especially in preparation for breeding), mark its territory, or simply to produce a pleasurable sensation to the animal. Because of its critical role in scent marking, the preorbital gland is usually considered as a type of scent gland. A further function of these glands may be to produce antimicrobial compounds against skin pathogens. Antimicrobial compounds found in these glands may be biosynthesized by the animal itself, or by microorganisms that live in these glands[Wikipedia:Preorbital_gland]." . [] oboInOwl:source "ncithesaurus:Lacrimal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "UMLS:C0022907" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "glandula lacrimalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "lacrimal-preorbital gland" . [] oboInOwl:hasDbXref "NCBITaxon:91561", "Wikipedia:Preorbital_gland" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "glandula praeorbitalis" . [] oboInOwl:hasDbXref "NCBITaxon:91561", "Wikipedia:Preorbital_gland" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "preorbital gland" . [] oboInOwl:hasDbXref "BTO:0000044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001817 ; owl:annotatedTarget "tear gland" . [] oboInOwl:source "ISBN:0123813611", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget obo:UBERON_0015251 . [] oboInOwl:hasDbXref "ISBN:0123813611", "PMID:20664693", "Wikipedia:Meibomian_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget "A modified lobulated sebaceous gland at the rim of an eyelid, responsible for the supply of meibum." . [] oboInOwl:source "ncithesaurus:Meibomian_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget "UMLS:C0025181" . [] oboInOwl:hasDbXref "MA:0001249" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget "Meibomian gland" . [] oboInOwl:hasDbXref "MA:0001249" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget "palpebral gland" . [] oboInOwl:hasDbXref "BTO:0004165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001818 ; owl:annotatedTarget "tarsoconjunctival gland" . [] oboInOwl:hasDbXref "MESH:D002628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000206 ; owl:annotatedTarget "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001819 ; owl:annotatedTarget obo:UBERON_0000161 . [] oboInOwl:hasDbXref "Wikipedia:Palpebral_fissure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001819 ; owl:annotatedTarget "Orifice separating upper and lower eyelids. In the human adult this measures about 10mm vertically and 30 mm horizontally. It can be reduced in size in fetal alcohol syndrome. In Trisomy 9 the palpebral fissures can be upslanting. [WP,modified]." . [] oboInOwl:hasDbXref "Wikipedia:Palpebral_fissure" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001819 ; owl:annotatedTarget "rima palpebrarum" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:16444816" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget _:genid120437 . [] oboInOwl:notes "coiled tubular" ; oboInOwl:source "Wikipedia:Tubular_gland" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget _:genid120439 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget _:genid120441 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "Any of the coil glands of the skin that secrete sweat." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001467" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/sweat+gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "A gland that secretes sweat, found in the dermis or subcutaneous tissue, opening by a duct on the body surface. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001467" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.101", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "Sweat glands (also called sudoriferous glands) are unique to mammals.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Sweat_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "UMLS:C0038989" . [] oboInOwl:hasDbXref "BTO:0001331" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "glandula sudorifera" . [] oboInOwl:hasDbXref "BTO:0001331" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "sudoriferous gland" . [] oboInOwl:hasDbXref "BTO:0001331" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001820 ; owl:annotatedTarget "sudoriparous gland" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget obo:UBERON_0012344 . [] oboInOwl:inconsistent_with "BTO" ; oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget _:genid120451 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget _:genid120455 . [] oboInOwl:hasDbXref "MP:0000647", "Wikipedia:Sebaceous_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001468" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/sebaceous+gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "Any of the numerous holocrine glands in the dermis that empty into a hair follicle and produce and secrete sebum. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001468" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.102", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "Sebaceous glands are also limited to mammals.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Sebaceous_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "UMLS:C0036505" . [] oboInOwl:hasDbXref "Wikipedia:Sebaceous_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "glandula sebacea" . [] oboInOwl:hasDbXref "BTO:0001980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "glandula sebaceae" . [] oboInOwl:hasDbXref "BTO:0001980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001821 ; owl:annotatedTarget "sebaceous follicle" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001823 ; owl:annotatedTarget obo:UBERON_0002418 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_cartilage" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001823 ; owl:annotatedTarget "One of the cartilage structures in the nose that provide form and support[WP]." . _:genid119830 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001823 ; owl:annotatedTarget "EMAPA:37681" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004128 . [] oboInOwl:source "ncithesaurus:Nasal_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001823 ; owl:annotatedTarget "UMLS:C0225415" . [] oboInOwl:hasDbXref "MP:0002261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx." . [] oboInOwl:source "ncithesaurus:Laryngeal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "UMLS:C0023053" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "larynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "larynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "larynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "mucosa of organ of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "organ mucosa of larynx" . [] oboInOwl:hasDbXref "FMA:59662", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "tunica mucosa laryngis" . [] oboInOwl:hasDbXref "EMAPA:18334" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001824 ; owl:annotatedTarget "laryngeal mucous membrane" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001825 ; owl:annotatedTarget "The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity." . _:genid119851 oboInOwl:source "ncithesaurus:Paranasal_Sinus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001825 ; owl:annotatedTarget "UMLS:C0030471" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "GAID:355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001825 ; owl:annotatedTarget "nasal sinus" . [] oboInOwl:hasDbXref "MP:0002238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001826 ; owl:annotatedTarget "The mucous membrane that lines the nasal cavity[MP]." . [] oboInOwl:hasDbXref "FMA:59684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001826 ; owl:annotatedTarget "mucosa of nose" . [] oboInOwl:hasDbXref "FMA:59684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001826 ; owl:annotatedTarget "mucous membrane of nose" . [] oboInOwl:hasDbXref "FMA:59684", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001826 ; owl:annotatedTarget "tunica mucosa nasi" . _:genid119867 oboInOwl:hasDbXref "Wikipedia:Tear", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001827 ; owl:annotatedTarget "Aqueous substance secreted by the lacrimal gland." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012430 . [] oboInOwl:source "ncithesaurus:Tear" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001827 ; owl:annotatedTarget "UMLS:C0039409" . _:genid119869 oboInOwl:hasDbXref "FMA:59756" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001827 ; owl:annotatedTarget "tear" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000347 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001827 ; owl:annotatedTarget "tears" . [] oboInOwl:hasDbXref "BTO:0001499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001827 ; owl:annotatedTarget "tear fluid" . _:genid119872 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003314, obo:UBERON_0011595 . _:genid119874 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0007213, obo:UBERON_0008266 . [] oboInOwl:source "Carranza" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget _:genid120514 . [] oboInOwl:source "ISBN:0013002015" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget _:genid120517 . [] oboInOwl:hasDbXref "ISBN:0013002015", "Wikipedia:Gingiva" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget "The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001]." . [] oboInOwl:source "ncithesaurus:Gingiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget "UMLS:C0017562" . [] oboInOwl:hasDbXref "FMA:59762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget "gum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001828 ; owl:annotatedTarget "gum tissue" . [] oboInOwl:hasDbXref "MP:0003792" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001829 ; owl:annotatedTarget "One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands." . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001829 ; owl:annotatedTarget "There are 3 pairs of major salivary glands in human and mouse" . [] oboInOwl:source "ncithesaurus:Major_Salivary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001829 ; owl:annotatedTarget "UMLS:C0930553" . _:genid119885 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567, obo:UBERON_0004479 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget _:genid120530 . [] oboInOwl:hasDbXref "Wikipedia:Parotid_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget "The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000308" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget "A mammalian salivary gland located caudal to the ear. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-22, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000209 ; owl:annotatedTarget "A specialized cell involved in gustatory sensory perception." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000308" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.525", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Parotid_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget "UMLS:C0030580" . [] oboInOwl:hasDbXref "Wikipedia:Parotid_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001831 ; owl:annotatedTarget "glandula parotidea" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget obo:UBERON_0001829 . [] oboInOwl:hasDbXref "MGI:hdene", "MP:0004035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000363" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/sublingual+gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "One of a pair of small salivary glands situated under the mucous membrane of the floor of the mouth, beneath the tongue. [TFD][VHOG]" . _:genid119897 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000363" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.553", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "Most mammals have well-developed parotid, mandibular, and sublingual glands.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "Single lobed in mouse; largest acini of the 3 rodent salivary glands. In human and mouse, secretions are predominantly mucinous" . [] oboInOwl:source "ncithesaurus:Sublingual_Salivary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "UMLS:C0038553" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:16923232" . [] oboInOwl:hasDbXref "BTO:0001315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "Rivinus gland" . [] oboInOwl:hasDbXref "Wikipedia:Sublingual_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "glandula sublingualis" . [] oboInOwl:hasDbXref "MA:0001589" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001832 ; owl:annotatedTarget "submaxillary gland" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget obo:UBERON_0003102 . _:genid119905 oboInOwl:source "BTO", "FMA-implicit", "VHOG", "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget _:genid120549 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001768 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget _:genid120551 . [] oboInOwl:hasDbXref "Wikipedia:Lip", "http://www.medterms.com/script/main/art.asp?articlekey=9458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget "One of the two fleshy folds which surround the opening of the mouth." . _:genid119908 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0007006" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator", "http//:www.medterms.com/script/main/art.asp?articlekey=9458" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget "Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO]" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001802 . [] oboInOwl:source "ncithesaurus:Lip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget "UMLS:C0023759" . [] oboInOwl:hasDbXref "Wikipedia:Lip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001833 ; owl:annotatedTarget "labia oris" . [] oboInOwl:hasDbXref "TAO:0001970", "Wikipedia:Upper_lip" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001834 ; owl:annotatedTarget "Lip that covers the upper portion of the mouth.[TAO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001750" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001834 ; owl:annotatedTarget "Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001970" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001834 ; owl:annotatedTarget "Lip that covers the upper portion of the mouth.[TAO]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001834 ; owl:annotatedTarget "upper jaw lip" . [] oboInOwl:hasDbXref "Wikipedia:Upper_lip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001834 ; owl:annotatedTarget "labium superius oris" . [] oboInOwl:hasDbXref "TAO:0002060", "Wikipedia:Lower_lip" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001835 ; owl:annotatedTarget "Lip that covers the lower portion of the mouth.[TAO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002060" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001835 ; owl:annotatedTarget "Lip that covers the lower portion of the mouth.[TAO]" . [] oboInOwl:source "ncithesaurus:Lower_Lip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001835 ; owl:annotatedTarget "UMLS:C0458583" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001835 ; owl:annotatedTarget "lower jaw lip" . _:genid119930 oboInOwl:hasDbXref "Wikipedia:Lower_lip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001835 ; owl:annotatedTarget "labium inferius oris" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 . [] oboInOwl:hasDbXref "GO:0046541", "Wikipedia:Saliva" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions." . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "We classify a wide variety of not necessarily homologous fluids here. In humans, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin" . [] oboInOwl:source "ncithesaurus:Saliva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "UMLS:C0036087" . [] oboInOwl:hasDbXref "FMA:59862" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "salivary gland secretion" . [] oboInOwl:hasDbXref "Wikipedia:Saliva" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "sailva normalis" . [] oboInOwl:hasDbXref "Wikipedia:Saliva" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "saliva atomaris" . [] oboInOwl:hasDbXref "Wikipedia:Saliva" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001836 ; owl:annotatedTarget "saliva molecularis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000210 ; owl:annotatedTarget obo:CL_0000006 . _:genid119947 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001837 ; owl:annotatedTarget "The duct of a salivary gland." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001775 . [] oboInOwl:hasDbXref "BTO:0005115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001837 ; owl:annotatedTarget "secretory duct" . _:genid119949 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001837 _:genid119951 ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0048770 . [] oboInOwl:hasDbXref "MESH:D010786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000210 ; owl:annotatedTarget "A cell specialized to detect and transduce light." . _:genid119951 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0001796, obo:UBERON_0001832 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001838 ; owl:annotatedTarget "A duct of a sublingual gland." . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001839 ; owl:annotatedTarget _:genid120603 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001839 ; owl:annotatedTarget _:genid120605 . [] oboInOwl:hasDbXref "Wikipedia:Bony_labyrinth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001839 ; owl:annotatedTarget "A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000211 ; owl:annotatedTarget "A cell whose function is determined by the generation or the reception of an electric signal." . [] oboInOwl:source "ncithesaurus:Osseous_Labyrinth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001839 ; owl:annotatedTarget "UMLS:C0458699" . [] oboInOwl:hasDbXref "Wikipedia:Bony_labyrinth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001839 ; owl:annotatedTarget "labyrinthus osseus" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget obo:UBERON_0000025 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget _:genid120612 . [] oboInOwl:source "OG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget _:genid120614 . [] oboInOwl:hasDbXref "Wikipedia:Semicircular_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "One of three half-circular, interconnected tubes located inside each ear[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000431" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "Fluid-filled toroidal spaces, arranged orthogonally to each other in the ear, that detect angular accelerations. (See Anatomical Atlas entry for semicircular canals by T. Whitfield.)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001144" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.414", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. These ducts are sometimes called canals, but technically the term semicircular canal applies to the spaces in the osseus labyrinth in which the semicircular ducts lie.[uncertain][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "MA divides this into osseous and duct. In FMA, this is systemically part of the bony labyrinth. Note this is an anatomical space in ZFA. The MA treatment has advantages for representing the neuroepithelium, which should not be part of bone. Also check duct vs canal" . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000213 ; owl:annotatedTarget "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." . [] oboInOwl:source "ncithesaurus:Semicircular_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "UMLS:C0036622" . [] oboInOwl:hasDbXref "TAO:0000431" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "semicircular canals" . [] oboInOwl:hasDbXref "Wikipedia:Semicircular_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "canalis semicircularis" . [] oboInOwl:hasDbXref "BTO:0003383", "FMA:71880", "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "ductus semicirculares" . [] oboInOwl:hasDbXref "TAO:0000431" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "scc" . [] oboInOwl:hasDbXref "XAO:0000198" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001840 ; owl:annotatedTarget "semicircular ducts" . [] oboInOwl:source "FMA", "VHOG", "XAO", "ncit" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget _:genid120627 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000031", "Wikipedia:Cochlea" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000691" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/cochlea" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "A spiral-shaped cavity in the petrous portion of the temporal bone of the inner ear, containing the nerve endings essential for hearing and forming one of the divisions of the labyrinth. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000691" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0959-4388(98)80033-0 Manley GA, Koeppl C, Phylogenetic development of the cochlea and its innervation. Current Opinion in Neurobiology (1998)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "Because achieving high sensitivity is generally advantageous for auditory organs, it is not surprising that evidence for cochlear amplification is also seen in nonmammals. Spontaneous otoacoustic emissions (SOAEs) are narrow-band sound signals emitted from the inner ear, and it is generally assumed that their energy derives from the hair-cell molecular motors underlying cochlear amplification. However, all terrestrial vertebrates studied so far (including amphibians) show very similar SOAEs. The most parsimonious explanation for the universality of this phenomena is that some kind of amplifying mechanism is at least as old as land vertebrates themselves.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "sources vary in connection to bony labyrinth" . [] oboInOwl:source "BIRNLEX:1190", "ncithesaurus:Cochlea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "UMLS:C0009195" . [] oboInOwl:source "BIRNLEX:1190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "UMLS:C1278895" . [] oboInOwl:hasDbXref "XAO:0000197" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "lagena" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "cochleae" . [] oboInOwl:hasDbXref "BTO:0000267" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "cochlear organ" . [] oboInOwl:hasDbXref "ZFA:0000374" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001844 ; owl:annotatedTarget "lagenas" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget _:genid120641 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000214 ; owl:annotatedTarget obo:CL_0002078 . [] oboInOwl:hasDbXref "PMID:16217737", "Wikipedia:Internal_ear", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000217" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "The auditory (hearing) and vestibular (balance) organ of the fish, equivalent to the inner ear of amniotes. (See Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000284" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.366", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" . _:genid119993 oboInOwl:source "BIRNLEX:1196", "ncithesaurus:Internal_Ear" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "UMLS:C0022889" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001787 . [] oboInOwl:source "BIRNLEX:1196" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "UMLS:C1268973" . [] oboInOwl:hasDbXref "BTO:0000630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001846 ; owl:annotatedTarget "auris interna" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:17053427" . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000215 ; owl:annotatedTarget "A cell whose primary function is to prevent the transport of stuff across compartments." . [] oboInOwl:hasDbXref "Wikipedia:Ear_lobe" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001847 ; owl:annotatedTarget "The soft lower part of the external ear, projecting below the antitragus." . [] oboInOwl:source "WP,unvetted" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0001847 ; owl:annotatedTarget "The earlobe is composed of tough areolar and adipose (fatty) connective tissues, lacking the firmness and elasticity of the rest of the pinna. Since the earlobe does not contain cartilage the earlobe has a large blood supply and may help to warm the ears and maintain balance but generally earlobes are not considered to have any major biological function." . [] oboInOwl:source "ncithesaurus:Lobule_of_the_Auricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001847 ; owl:annotatedTarget "UMLS:C0229315" . [] oboInOwl:hasDbXref "FMA:60984", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001847 ; owl:annotatedTarget "lobulus auriculae" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/auricular+cartilage" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001848 ; owl:annotatedTarget "Cartilage of the pinna and much of the external ear canal." . [] oboInOwl:hasDbXref "FMA:61013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001848 ; owl:annotatedTarget "cartilage of pinna" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget _:genid120665 . [] oboInOwl:hasDbXref "FMA:61022", "Wikipedia:Membranous_labyrinth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000729" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/membranous+labyrinth" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "A system of communicating epithelial sacs and ducts within the bony labyrinth, containing the endolymph. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000729" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.366", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "inner ear has parts membranous and osseuous/bony labyrinth. it's not clear where the EMAPA term 'labyrinth' belong, we place them here for now" . [] oboInOwl:source "ncithesaurus:Membranous_Labyrinth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "UMLS:C0458700" . [] oboInOwl:hasDbXref "Wikipedia:Membranous_labyrinth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001849 ; owl:annotatedTarget "labyrinthus membranaceus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001850 ; owl:annotatedTarget obo:UBERON_0000062 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001850 ; owl:annotatedTarget _:genid120676 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001850 ; owl:annotatedTarget "A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct." . [] oboInOwl:hasDbXref "FMA:61063", "MA:0001295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001850 ; owl:annotatedTarget "lacrimal duct" . [] oboInOwl:hasDbXref "MA:0001295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001850 ; owl:annotatedTarget "tear duct" . [] oboInOwl:hasDbXref "Wikipedia:Cortex_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001851 ; owl:annotatedTarget "Outermost layer of an organ[WP]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001851 ; owl:annotatedTarget "this class is used more generically than in FMA, and includes e.g. cortex of hair" . [] oboInOwl:hasDbXref "FMA:61109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001851 ; owl:annotatedTarget "cortex" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget _:genid120688 . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000507" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/cochlear+duct" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "The coiled portion of the membranous labyrinth located inside the cochlea. It contains endolymph. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000507" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.413-414", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. (...) In all gnathostomes, the utriculus connects ventrally with a larger sac, called the sacculus (...) In most groups of gnathostomes, the caudoventral evagination of the sacculus forms a small lagena, and in some diapsids and mammals the lagena develops into a longer duct. The lagena becomes greatly elongated in therians and coils to form the cochlear duct.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:2562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "UMLS:C1281166" . [] oboInOwl:source "BIRNLEX:2562", "ncithesaurus:Cochlear_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "UMLS:C1323110" . [] oboInOwl:hasDbXref "FMA:61119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "Reissner's canal" . [] oboInOwl:hasDbXref "BIRNLEX:2562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "Reissners canal" . [] oboInOwl:hasDbXref "BIRNLEX:2562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "cochlea duct" . [] oboInOwl:hasDbXref "BIRNLEX:2562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "scala medias" . [] oboInOwl:hasDbXref "BTO:0001692", "Wikipedia:Cochlear_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "ductus cochlearis" . [] oboInOwl:hasDbXref "BTO:0001692" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "membranous cochlea" . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "scala media" . [] oboInOwl:hasDbXref "BTO:0001692" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001855 ; owl:annotatedTarget "scala of Loewenberg" . [] oboInOwl:hasDbXref "BTO:0001856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001862 ; owl:annotatedTarget "The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals." . _:genid120049 oboInOwl:source "ncithesaurus:Vestibular_Labyrinth" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001862 ; owl:annotatedTarget "UMLS:C0042606" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000287 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000216 ; owl:annotatedTarget obo:CL_0000630 . [] oboInOwl:hasDbXref "EHDAA2:0000832" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001862 ; owl:annotatedTarget "inner ear vestibular component" . [] oboInOwl:hasDbXref "BTO:0001856" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001862 ; owl:annotatedTarget "labyrinthus vestibularis" . [] oboInOwl:hasDbXref "BTO:0001981", "Wikipedia:Sebaceous_glands#Sebum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001866 ; owl:annotatedTarget "Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP]." . [] oboInOwl:source "ncithesaurus:Sebum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001866 ; owl:annotatedTarget "UMLS:C0036511" . [] oboInOwl:hasDbXref "MESH:D012708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000216 ; owl:annotatedTarget "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001867 ; owl:annotatedTarget "A cartilage that is part of a external ear [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001867 ; owl:annotatedTarget "EMAPA:37706" . [] oboInOwl:source "ncithesaurus:External_Ear_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001867 ; owl:annotatedTarget "UMLS:C0013445" . _:genid120072 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "A zone of skin that is part of a chest [Automatically generated definition]." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:CL_0000287 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "EMAPA:37279" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "anterior thoracic region zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "anterolateral part of thorax zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "chest zone of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "front of thorax zone of skin" . [] oboInOwl:hasDbXref "FMA:61416" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of anterior chest" . [] oboInOwl:hasDbXref "FMA:61416" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of anterior part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of front of thorax" . [] oboInOwl:hasDbXref "FMA:61417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001868 ; owl:annotatedTarget "zone of skin of pectoral part of chest" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget _:genid120743 . [] oboInOwl:hasDbXref "FMA:61817", "Wikipedia:Cerebral_hemisphere" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010480" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001639" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.ne.04.030181.001505 Northcutt RG, Evolution of the telencephalon in nonmammals. Ann. Rev. Neurosci. (1981)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cerebral_Hemisphere" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "UMLS:C0228174" . [] oboInOwl:source "BIRNLEX:1042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "UMLS:C0242202" . [] oboInOwl:source "BIRNLEX:1042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "neuronames:241" . [] oboInOwl:hasDbXref "MA:0000133", "VHOG:0001639", "https://github.com/obophenotype/uberon/issues/1208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "cerebrum" . [] oboInOwl:hasDbXref "VHOG:0001639" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "hemisphere" . [] oboInOwl:hasDbXref "BAMS:HEM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "hemispheric regions" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_hemisphere" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "hemispherium cerebri" . [] oboInOwl:hasDbXref "NeuroNames:241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "medial amygdalar nucleus" . [] oboInOwl:hasDbXref "NeuroNames:241" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "nucleus amygdaloideus medialis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:17081118" . [] oboInOwl:hasDbXref "NeuroNames:241" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001869 ; owl:annotatedTarget "nucleus medialis amygdalae" . [] oboInOwl:hasDbXref "NLXANAT:20090601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified]." . [] oboInOwl:source "NLXANAT:20090601" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "Anterior portion of the frontal cortex, lying anterior to the central sulcus. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally." . [] oboInOwl:hasDbXref "FMA:242199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "cortex of frontal lobe" . [] oboInOwl:hasDbXref "FMA:242199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "frontal lobe cortex" . [] oboInOwl:hasDbXref "FMA:242199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "gray matter of frontal lobe" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000219 ; owl:annotatedTarget "A cell that moves by its own activities." . [] oboInOwl:hasDbXref "DHBA:10161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001870 ; owl:annotatedTarget "frontal neocortex" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget obo:UBERON_0016526 . [] oboInOwl:hasDbXref "BIRNLEX:1160" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget "Lower lateral part of the cerebral hemisphere. (MSH)." . _:genid120114 oboInOwl:source "BIRNLEX:1160", "ncithesaurus:Temporal_Lobe" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget "UMLS:C0039485" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 . [] oboInOwl:source "BIRNLEX:1160" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget "UMLS:C1268978" . [] oboInOwl:source "BIRNLEX:1160" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget "neuronames:125" . [] oboInOwl:hasDbXref "Wikipedia:Temporal_lobe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001871 ; owl:annotatedTarget "lobus temporalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget obo:UBERON_0016526 . [] oboInOwl:hasDbXref "BIRNLEX:1148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget "Upper central part of the cerebral hemisphere. (MSH)." . [] oboInOwl:source "BIRNLEX:1148", "ncithesaurus:Parietal_Lobe_of_the_Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget "UMLS:C0030560" . [] oboInOwl:source "BIRNLEX:1148" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget "neuronames:95" . [] oboInOwl:hasDbXref "FMA:61826", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget "regio parietalis" . [] oboInOwl:hasDbXref "Wikipedia:Parietal_lobe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001872 ; owl:annotatedTarget "lobus parietalis" . [] oboInOwl:is_redundant "true" ; oboInOwl:source "EHDAA2", "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget _:genid120783 . [] oboInOwl:is_redundant "true" ; oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget _:genid120785 . _:genid120129 oboInOwl:is_redundant "true" ; oboInOwl:source "NIFSTD" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget _:genid120787 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003902 . [] oboInOwl:hasDbXref "MESH:D004475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000221 ; owl:annotatedTarget "A cell of the outer of the three germ layers of the embryo." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget _:genid120789 . [] oboInOwl:hasDbXref "BIRNLEX:1373" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species." . [] oboInOwl:source "FMA:61833" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833]." . [] oboInOwl:source "BIRNLEX:1373", "ncithesaurus:Caudate_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "UMLS:C0007461" . [] oboInOwl:source "BIRNLEX:1373" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "neuronames:226" . [] oboInOwl:hasDbXref "BAMS:CA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "Ammon horn fields" . [] oboInOwl:hasDbXref "BTO:0000211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "caudatum" . [] oboInOwl:hasDbXref "BTO:0000211", "Wikipedia:Caudate_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001873 ; owl:annotatedTarget "nucleus caudatus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget obo:UBERON_0002308 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget _:genid120800 . [] oboInOwl:hasDbXref "BIRNLEX:809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." . [] oboInOwl:source "Wikipedia:Putamen" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget "Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001456" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Putamen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget "UMLS:C0034169" . [] oboInOwl:source "BIRNLEX:809" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001874 ; owl:annotatedTarget "neuronames:230" . [] oboInOwl:hasDbXref "MESH:D008648" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000222 ; owl:annotatedTarget "A cell of the middle germ layer of the embryo." . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget _:genid120811 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget _:genid120813 . [] oboInOwl:source "BTO-weakened" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget _:genid120815 . [] oboInOwl:source "GO", "ISBN:1588900649" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget _:genid120817 . [] oboInOwl:hasDbXref "BIRNLEX:1234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "Subcortical nucleus, functionally part of the basal ganglia, which consists of two segments the external (or lateral) and internal (or medial) separated by the medial medullary lamina in primates. In rodents, The globus pallidus lateral is separated from the medial segment by the fibers of the internal capsule/cerebral peduncle." . [] oboInOwl:source "FMA:61835" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "Nucleus of brain which is located medially to the putamen and laterally to the internal capsule[FMA][FMA:61835]." . [] oboInOwl:source "BIRNLEX:1234", "ncithesaurus:Globus_Pallidus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "UMLS:C0017651" . [] oboInOwl:source "BIRNLEX:1234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "neuronames:231" . [] oboInOwl:hasDbXref "BIRNLEX:1234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "pale body" . [] oboInOwl:hasDbXref "Wikipedia:Globus_pallidus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "paleostriatum" . [] oboInOwl:hasDbXref "NeuroNames:231" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "globus pallidus (Burdach)" . [] oboInOwl:hasDbXref "NeuroNames:231" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "nucleus pallidus" . [] oboInOwl:hasDbXref "Wikipedia:Globus_pallidus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "pallidium" . [] oboInOwl:hasDbXref "BIRNLEX:1234", "GO:0021759", "Wikipedia:Globus_pallidus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001875 ; owl:annotatedTarget "pallidum" . [] oboInOwl:hasDbXref "MESH:D004707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000223 ; owl:annotatedTarget "A cell of the inner of the three germ layers of the embryo." . [] oboInOwl:hasDbXref "VHOG:0000728" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000728" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/phrenic+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Phrenic_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "UMLS:C0031774" . [] oboInOwl:hasDbXref "BTO:0001063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "diaphragmatic nerve" . [] oboInOwl:hasDbXref "BTO:0001063", "Wikipedia:Phrenic_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "nervus phrenicus" . [] oboInOwl:hasDbXref "BTO:0001063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001884 ; owl:annotatedTarget "phrenic" . [] oboInOwl:hasDbXref "ISBN:0471888893", "Wikipedia:Choroid_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001443" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "A tuft of capillaries that project into the ventricles of the brain and secretes cerebral spinal fluid. The choroid plexus is covered by a cuboidal epithelium which maintains the integrity of the blood-brain barrier.[TAO]" . [] oboInOwl:source "MP:0000820" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "Fringe of the tela choroidea of the brain ventricles[MP]" . _:genid120182 oboInOwl:hasDbXref "PMID:23375746" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "CP" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001766 . [] oboInOwl:source "ncithesaurus:Choroid_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "UMLS:C0008524" . [] oboInOwl:hasDbXref "FMA:61934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "chorioid plexus" . [] oboInOwl:hasDbXref "FMA:61934", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "plexus choroideus" . [] oboInOwl:hasDbXref "FMA:61934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "choroid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "Wikipedia:Choroid_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001886 ; owl:annotatedTarget "plexus choroideus" . [] oboInOwl:hasDbXref "BIRNLEX:1659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001887 ; owl:annotatedTarget "White matter regional part of brain which is flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem and spinal cord. It consists of three distinct parts: an anterior limb, posterior limb, and genu. (Adapted from MSH by Maryann Martone)." . [] oboInOwl:hasDbXref "MA:0002748" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001887 ; owl:annotatedTarget "internal capsule" . [] oboInOwl:source "BIRNLEX:1659", "ncithesaurus:Internal_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001887 ; owl:annotatedTarget "UMLS:C0152341" . [] oboInOwl:hasDbXref "MP:0008128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001887 ; owl:annotatedTarget "brain internal capsule" . [] oboInOwl:hasDbXref "Wikipedia:Internal_capsule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001887 ; owl:annotatedTarget "capsula interna" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001889 ; owl:annotatedTarget "EMAPA:37718" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:17875433" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget _:genid120868 . [] oboInOwl:hasDbXref "Wikipedia:Forebrain", "ZFIN:ZDB-PUB-961014-576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "The most anterior region of the brain including both the telencephalon and diencephalon." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010147" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000109" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000109" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" . _:genid120207 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000383" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:8787764 Holland ND, Panganiban G, Henyey EL, Holland LZ, Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest. Development (1996)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG]" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002346 . [] oboInOwl:hasDbXref "BIRNLEX:1509", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "FB" . [] oboInOwl:source "BIRNLEX:1509", "ncithesaurus:Fore-Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "UMLS:C0085140" . [] oboInOwl:source "BIRNLEX:1509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001890 ; owl:annotatedTarget "neuronames:27" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget _:genid120879 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget _:genid120882 . [] oboInOwl:hasDbXref "GO:0030901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:exceptions_url "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:source "ABA" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget obo:UBERON_0001894 . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "ABA" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget obo:UBERON_0002028 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010149" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "Middle part of the brain composed of the optic tectum and penducular region.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000128" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO]" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000225 ; owl:annotatedTarget "A cell that lacks a nucleus." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000069" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" . [] oboInOwl:external_ontology "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships" . [] oboInOwl:hasDbXref "BIRNLEX:1667", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "MB" . [] oboInOwl:source "BIRNLEX:1667", "ncithesaurus:Mesencephalon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "UMLS:C0025462" . [] oboInOwl:source "BIRNLEX:1667" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "neuronames:462" . [] oboInOwl:hasDbXref "Wikipedia:Midbrain" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001891 ; owl:annotatedTarget "mesencephalon" . [] oboInOwl:hasDbXref "Wikipedia:Rhombomere", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001064" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "A segment of the developing hindbrain. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000672" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1006/dbio.2002.0831 Mazet F, Shimeld SM, The Evolution of Chordate Neural Segmentation. Developmental Biology (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "hindbrain segment" . _:genid120234 oboInOwl:hasDbXref "ZFA:0001064" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "segment of hindbrain" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 . [] oboInOwl:hasDbXref "DHBA:HNM" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "hindbrain neuromeres" . _:genid120236 oboInOwl:hasDbXref "MIAA:0000272" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "future rhombencephalon" ; owl:onProperty obo:BSPO_0000123 ; owl:someValuesFrom obo:UBERON_0010230 . [] oboInOwl:hasDbXref "VHOG:0000672" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001892 ; owl:annotatedTarget "rhombomeres" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget _:genid120908 . [] oboInOwl:hasDbXref "AAO:0010479", "XAO:0000012" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget obo:UBERON_0002037 . [] oboInOwl:source "FMA:62000" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010479" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000079" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO]" . _:genid120245 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000079" ; oboInOwl:ontology "TAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000283" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG]" . _:genid120247 oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "In mammals the cortex covers almost the whole of the cerebral hemispheres." ; owl:onProperty obo:BSPO_0000122 ; owl:someValuesFrom obo:UBERON_0010230 . [] oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles." . [] oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum." . [] oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb." . [] oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure." . [] oboInOwl:source "Wikipedia:Telencephalon#Variation_among_species" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight." . [] oboInOwl:hasDbXref "Wikipedia:Tentorium_cerebelli" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "supratentorial region" . [] oboInOwl:source "BIRNLEX:1115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "UMLS:C0039452" . [] oboInOwl:source "BIRNLEX:1115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "neuronames:31" . [] oboInOwl:hasDbXref "BTO:0000239", "EMAPA:16910", "FMA:62000", "Wikipedia:Talk:Cerebrum/Archive_1", "https://github.com/obophenotype/uberon/issues/1208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "cerebrum" . [] oboInOwl:hasDbXref "Swanson:2004", "neuronames:31" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001893 ; owl:annotatedTarget "endbrain" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget _:genid120929 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget _:genid120932 . [] oboInOwl:hasDbXref "Wikipedia:Diencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "The division of the forebrain that develops from the foremost primary cerebral vesicle." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "ABA", "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget obo:UBERON_0001891 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget obo:UBERON_0002028 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000101" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010481" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000318" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" . [] oboInOwl:external_ontology "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "in ABA, this is part of the brain stem" . [] oboInOwl:hasDbXref "BIRNLEX:1503", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "DiE" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000226 ; owl:annotatedTarget "A cell with a single nucleus." . [] oboInOwl:source "BIRNLEX:1503", "ncithesaurus:Diencephalon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "UMLS:C0012144" . [] oboInOwl:source "BIRNLEX:1503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "neuronames:288" . [] oboInOwl:hasDbXref "Swanson:2004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "interbrain" . [] oboInOwl:hasDbXref "FMA:62001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "mature diencephalon" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "thalamencephalon" . _:genid120275 oboInOwl:hasDbXref "BTO:0000342" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "betweenbrain" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001803 . [] oboInOwl:hasDbXref "Wikipedia:Diencephalon" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001894 ; owl:annotatedTarget "diencephalon" . _:genid120277 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002028, obo:UBERON_0005614 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget _:genid120951 . [] oboInOwl:hasDbXref "Wikipedia:Metencephalon", "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." . [] oboInOwl:source "BIRNLEX:965" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "Anterior part of the hindbrain ventral to the cerebellum[BIRNLEX:965]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000741" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/metencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000741" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "ncithesaurus:Epencephalon" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "epencephalon" . [] oboInOwl:source "BIRNLEX:965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "UMLS:C0376353" . [] oboInOwl:source "ncithesaurus:Epencephalon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "UMLS:C1516904" . [] oboInOwl:source "BIRNLEX:965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "neuronames:543" . [] oboInOwl:hasDbXref "FMA:62003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001895 ; owl:annotatedTarget "epencephalon-2" . [] oboInOwl:hasDbXref "FMA:62004", "GO:0021550", "Wikipedia:Bone_marrow_of_ovary_oblongata" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010486" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000181" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000181" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" . [] oboInOwl:hasDbXref "ABA:MY" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "medulla" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:17997039" . [] oboInOwl:source "BIRNLEX:957", "ncithesaurus:Medulla_Oblongata" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "UMLS:C0025148" . _:genid120301 oboInOwl:source "BIRNLEX:957" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "UMLS:C1269575" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003083 . [] oboInOwl:source "BIRNLEX:957" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "neuronames:698" . [] oboInOwl:hasDbXref "FMA:62004", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "bulbus" . [] oboInOwl:hasDbXref "Wikipedia:Medulla_oblongata" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "medulla oblonzata" . [] oboInOwl:hasDbXref "FMA:62004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001896 ; owl:annotatedTarget "metepencephalon" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget _:genid120980 . [] oboInOwl:hasDbXref "BIRNLEX:954" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget obo:UBERON_0001898 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000657" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/thalamus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "One of a pair of large oval nervous structures made of gray matter and forming most of the lateral walls of the third ventricle of the brain and part of the diencephalon. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010483" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "Part of the diencephalon consisting of a mass of connecting fibers which relay sensory information to the cerebral cortex.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000657" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.484", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "(...) the brain regions of tetrapods, the structures they contain, and their basic organizational features are the same as in fishes.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:954", "NIFSTD:NeuroNames_abbrevSource", "PMID:23375746" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "Th" . [] oboInOwl:hasDbXref "FMA:62007", "MA:0000179" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "thalamus" . _:genid120316 oboInOwl:source "BIRNLEX:954", "ncithesaurus:Thalamus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "UMLS:C0039729" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "BIRNLEX:954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "neuronames:300" . [] oboInOwl:hasDbXref "PMCID:PMC3345571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "wider thalamus" . [] oboInOwl:hasDbXref "NeuroNames:300" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "thalamencephalon" . [] oboInOwl:hasDbXref "VHOG:0000657" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "thalami" . [] oboInOwl:hasDbXref "NeuroNames:300" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001897 ; owl:annotatedTarget "thalamus opticus" . [] oboInOwl:missing_from "FMA" ; oboInOwl:source "EHDAA2", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget _:genid120997 . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget _:genid120999 . [] oboInOwl:hasDbXref "Wikipedia:Hypothalamus", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget obo:UBERON_0001897 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000032" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010484" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "Part of the diencephalon ventral to the thalamus consisting of connecting fibers and is a center for control of the autonomous nervous system.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000179" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "For instance, the vertebrate ventral diencephalon generates the hypothalamus which functions as a major endocrine center in cooperation with the hypophysis, the anterior part of the pituitary gland, located just ventral to the hypothalamus. In the amphioxus brain, the presence of a hypothalamus-like structure has been reported associated with the ventrally located Hatschek's pit, the hypothetical hypophysial homologue. It is thus conceivable that a hypothalamus-like structure originally involved in endocrine functions may have already been present before the establishment of vertebrates.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "all vertebrates contain a hypothalamus" . [] oboInOwl:hasDbXref "BIRNLEX:734", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "Hy" . _:genid120333 oboInOwl:source "BIRNLEX:734", "ncithesaurus:Hypothalamus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "UMLS:C0020663" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000526 . [] oboInOwl:source "BIRNLEX:734" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "neuronames:292" . _:genid120335 oboInOwl:hasDbXref "Wikipedia:Hypothalamus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001898 ; owl:annotatedTarget "hypothalamus" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000527 . [] oboInOwl:hasDbXref "BIRNLEX:1710" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget obo:UBERON_0001903 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget obo:UBERON_0002733 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget obo:UBERON_0002736 . _:genid120342 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010482" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "Dorsal segment of the diencephalon containing the habenular ganglia, a choroid plexus, and the pineal organ.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005908 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000178" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "The roof of the diencephalon lying above the thalamus. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-11, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . _:genid120344 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000178" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910063.x Concha ML and Wilson SW, Asymmetry in the epithalamus of vertebrates. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "The epithalamus has been historically conceived as a distinct neuroanatomical moiety within the diencephalon of all vertebrates. (...) The evolutionary origins of epithalamic structures are uncertain but asymmetry in this region is likely to have existed at the origin of the vertebrate, perhaps even the chordate, lineage.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010409 . [] oboInOwl:hasDbXref "BIRNLEX:1710", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "ETh" . _:genid120346 oboInOwl:source "BIRNLEX:1710", "ncithesaurus:Epithalamus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "UMLS:C0152361" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:source "BIRNLEX:1710" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "neuronames:292" . [] oboInOwl:hasDbXref "Wikipedia:Epithalamus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001899 ; owl:annotatedTarget "epithalamus" . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002285" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "The epithelial lining of the trachea which contains numerous ciliated cells." . [] oboInOwl:source "ncithesaurus:Tracheal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "UMLS:C1179002" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "epithelial tissue of trachea" . _:genid120358 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "epithelial tissue of windpipe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "epithelium of windpipe" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000228 ; owl:annotatedTarget "A cell with more than one nucleus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "trachea epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "windpipe epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001901 ; owl:annotatedTarget "windpipe epithelium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget _:genid121044 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "An epithelium that is part of a small intestine [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005127" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "Intestinal epithelium which lines the lumen of the mid intestine.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "epithelial tissue of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "epithelial tissue of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "epithelium of small bowel" . [] oboInOwl:hasDbXref "ZFA:0005127" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "mid intestine epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "small bowel epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "small bowel epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001902 ; owl:annotatedTarget "small intestine epithelial tissue" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget obo:UBERON_0010134 . [] oboInOwl:source "ZFA", "various" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget _:genid121056 . [] oboInOwl:editor_note "add secretion" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget _:genid121060 . [] oboInOwl:hasDbXref "BIRNLEX:1184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget obo:UBERON_0001941 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget obo:UBERON_0001942 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000019" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "A circumscribed swelling, includes the pineal primordium that appears late in the segmentation period in the dorsal midline of the diencephalon. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010549" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "Anatomical structure which is a medial outgrowth of the thalamus on the dorsal surface of the brain. This structure is light sensitive and secretes melatonin when exposed to prolonged darkness.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000019" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "relationship loss: part_of pineal complex (TAO:0001359)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000051" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.516", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "The pineal gland has evolved from a part of the epiphyseal complex of anamniotes, which includes a median light-receptive pineal eye, parietal eye, or both.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1184", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "Pi" . [] oboInOwl:source "BIRNLEX:1184", "ncithesaurus:Pineal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "UMLS:C0031939" . [] oboInOwl:source "BIRNLEX:1184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "neuronames:297" . [] oboInOwl:hasDbXref "FMA:62033", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "glandula pinealis" . [] oboInOwl:hasDbXref "FMA:62033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "pineal gland" . [] oboInOwl:hasDbXref "ZFA:0000019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "pineal organ" . [] oboInOwl:hasDbXref "BIRNLEX:1184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "conarium" . [] oboInOwl:hasDbXref "ZFA:0000019" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "epiphysis" . [] oboInOwl:hasDbXref "Wikipedia:Epiphysis_cerebri" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "epiphysis cerebri" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:18060526" . [] oboInOwl:hasDbXref "VHOG:0000051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "frontal organ" . [] oboInOwl:hasDbXref "VHOG:0000051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "pineal" . [] oboInOwl:hasDbXref "NeuroNames:297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "pineal gland (Galen)" . [] oboInOwl:hasDbXref "VHOG:0000051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001905 ; owl:annotatedTarget "stirnorgan" . [] oboInOwl:hasDbXref "NIFSTD", "Wikipedia:Optic_tract", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF]." . [] oboInOwl:source "BIRNLEX:1684", "ncithesaurus:Optic_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "UMLS:C0152405" . [] oboInOwl:source "BIRNLEX:1684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "neuronames:460" . [] oboInOwl:hasDbXref "ZFA:0000252" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "optic tracts" . [] oboInOwl:hasDbXref "NeuroNames:460" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "tractus optici" . [] oboInOwl:hasDbXref "Wikipedia:Optic_tract" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "tractus opticus" . [] oboInOwl:hasDbXref "GAID:735" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001908 ; owl:annotatedTarget "visual pathway" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:hasDbXref "BTO:0000817", "Wikipedia:Mammary_gland", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000398" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mammary+gland" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "Any of the milk-producing apocrine glands typically occurring in pairs in female mammals and consisting of lobes containing clusters of alveoli with a system of ducts to convey the milk to an external nipple or teat. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000398" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.224", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Mammary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "UMLS:C0929301" . [] oboInOwl:hasDbXref "FMA:57983", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "glandula mammaria" . [] oboInOwl:hasDbXref "FMA:62088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "lactiferous gland" . [] oboInOwl:hasDbXref "NCBITaxon:9255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "milk patch" . [] oboInOwl:hasDbXref "BTO:0000817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "Brustdruese" . [] oboInOwl:hasDbXref "Wikipedia:Mammary_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "dug" . [] oboInOwl:hasDbXref "Wikipedia:Mammary_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "glandula mammaria" . [] oboInOwl:hasDbXref "FMA:62088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "lobe of mammary gland" . [] oboInOwl:hasDbXref "BTO:0000817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "mamma" . _:genid120437 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001911 ; owl:annotatedTarget "mammae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . _:genid120439 a owl:Restriction ; owl:onProperty obo:RO_0000086, obo:RO_0002433 ; owl:someValuesFrom obo:PATO_0002299, obo:UBERON_0001911 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget obo:UBERON_0009911 . _:genid120441 oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005089 . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "acinus of mammary gland" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "lactiferous acinus" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "lactiferous gland lobule" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "lactiferous lobule" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "lobule of lactiferous gland" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "lobule of mammary gland" . [] oboInOwl:hasDbXref "FMA:62090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "mammary acinus" . [] oboInOwl:hasDbXref "MA:0000793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001912 ; owl:annotatedTarget "mammary gland lobule" . _:genid120451 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000028527, obo:UBERON_0001003 . _:genid120455 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001913 ; owl:annotatedTarget "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005088 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001263" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.224", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001913 ; owl:annotatedTarget "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001913 ; owl:annotatedTarget "ncit:Milk refers specifically to cow milk" . [] oboInOwl:source "ncithesaurus:Breast_Fluid_or_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001913 ; owl:annotatedTarget "UMLS:C1511310" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "An endothelium that is part of a capillary [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Capillary_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "UMLS:C0006904" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "blood capillary endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "capillary vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "endothelium of blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001915 ; owl:annotatedTarget "endothelium of capillary vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001916 ; owl:annotatedTarget "An endothelium that is part of an arteriole [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Arteriole_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001916 ; owl:annotatedTarget "UMLS:C1179024" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001917 ; owl:annotatedTarget "An endothelium that is part of an artery [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011013" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001917 ; owl:annotatedTarget "The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001215" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001917 ; owl:annotatedTarget "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Artery_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001917 ; owl:annotatedTarget "UMLS:C1179025" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001918 ; owl:annotatedTarget "An endothelium that is part of a venule [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Venule_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001918 ; owl:annotatedTarget "UMLS:C1179026" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001919 ; owl:annotatedTarget "An endothelium that is part of a vein [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001216" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001919 ; owl:annotatedTarget "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Vein_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001919 ; owl:annotatedTarget "UMLS:C1179027" . [] oboInOwl:hasDbXref "VHOG:0001216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001919 ; owl:annotatedTarget "veinous endothelium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:18171928" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000232 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget _:genid121181 . [] oboInOwl:hasDbXref "FMA:FMA", "ISBN:0471888893", "Wikipedia:Midbrain_tegmentum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001367" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1200", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "MTg" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "tegmentum" . [] oboInOwl:source "BIRNLEX:1200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "UMLS:C0039441" . [] oboInOwl:source "BIRNLEX:1200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "neuronames:491" . [] oboInOwl:hasDbXref "Wikipedia:Midbrain_tegmentum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "tegmentum mesencephali" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D004912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000232 ; owl:annotatedTarget "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." . [] oboInOwl:hasDbXref "VHOG:0001367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "mesencephalic tegmentum" . [] oboInOwl:hasDbXref "NeuroNames:491" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001943 ; owl:annotatedTarget "tegmentum mesencephalicum" . _:genid120514 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240, obo:UBERON_0003729 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001948 ; owl:annotatedTarget "A multi-tissue structure that is part of a spinal cord." . _:genid120517 oboInOwl:source "ncithesaurus:Spinal_Cord_Part" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001948 ; owl:annotatedTarget "UMLS:C1268166" ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0003729 . [] oboInOwl:hasDbXref "BTO:0004998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001949 ; owl:annotatedTarget "A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO]." . [] oboInOwl:source "ncithesaurus:Gingival_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001949 ; owl:annotatedTarget "UMLS:C1179154" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001949 ; owl:annotatedTarget "epithelial tissue of gingiva" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001949 ; owl:annotatedTarget "gingiva epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001949 ; owl:annotatedTarget "gingiva epithelium" . [] oboInOwl:hasDbXref "BIRNLEX:2547", "OldNeuroNames:754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN)." . _:genid120530 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget obo:UBERON_0002264 ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001710 . [] oboInOwl:source "PMID:23027930" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils" . [] oboInOwl:source "BIRNLEX:2547" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "UMLS:C0175173" . [] oboInOwl:source "BIRNLEX:2547" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "neuronames:757" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "homogenetic cortex" . [] oboInOwl:hasDbXref "BIRNLEX:2547" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "homotypical cortex" . [] oboInOwl:hasDbXref "FMA:62429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "isocortex (sensu lato)" . [] oboInOwl:hasDbXref "DHBA:10160" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "neocortex (isocortex)" . [] oboInOwl:hasDbXref "BRAINSPAN:BRAINSPAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "isocortex" . [] oboInOwl:hasDbXref "BAMS:iso-cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "iso-cortex" . [] oboInOwl:hasDbXref "BTO:0000920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "nonolfactory cortex" . [] oboInOwl:hasDbXref "NeuroNames:757" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001950 ; owl:annotatedTarget "nucleus hypoglossalis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget _:genid121226 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "An epithelium that is part of a nasopharynx [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Nasopharynx_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "UMLS:C1179157" . _:genid120549 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "epithelial tissue of nasal part of pharynx" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "epithelial tissue of nasopharynx" . _:genid120551 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "epithelial tissue of rhinopharynx" ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000166 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "epithelium of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "epithelium of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "nasal part of pharynx epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "nasal part of pharynx epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "nasopharynx epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "rhinopharynx epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "rhinopharynx epithelium" . [] oboInOwl:hasDbXref "BTO:0004480" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001951 ; owl:annotatedTarget "nasopharyngeal epithelium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget _:genid121241 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget _:genid121243 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget _:genid121245 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget _:genid121247 . [] oboInOwl:hasDbXref "BIRNLEX:721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget obo:UBERON_0001885 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget obo:UBERON_0002601 . [] oboInOwl:source "BIRNLEX:721", "ncithesaurus:Hippocampus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "UMLS:C0019564" . [] oboInOwl:hasDbXref "GO:0021541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "Ammon's horn" . [] oboInOwl:hasDbXref "GO:0021541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "ammon gyrus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000233 ; owl:annotatedTarget obo:CL_0000763 . [] oboInOwl:hasDbXref "BIRNLEX:721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "ammon horn" . [] oboInOwl:hasDbXref "BIRNLEX:721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "hippocampus proper" . [] oboInOwl:hasDbXref "FMA:62493", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "hippocampus proprius" . [] oboInOwl:hasDbXref "BAMS:CA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "Ammon horn fields" . [] oboInOwl:hasDbXref "BTO:0003705" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "Ammons horn" . [] oboInOwl:hasDbXref "GO:0021541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "cornu ammonis" . [] oboInOwl:hasDbXref "MA:0000191" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001954 ; owl:annotatedTarget "hippocampus" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D001792", "PMID:11110672", "PMID:16987572", "PMID:17204662", "PMID:17479180", "PMID:20414831", "http://en.wikipedia.org/wiki/Platelet" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000233 ; owl:annotatedTarget "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget _:genid121267 . [] oboInOwl:hasDbXref "MP:0010988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." . [] oboInOwl:source "ncithesaurus:Bronchus_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "UMLS:C0225604" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "bronchi cartilage" . [] oboInOwl:hasDbXref "MP:0010988" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "bronchial cartilage ring" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "bronchial trunk cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "cartilage of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "cartilage of bronchial trunk" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001956 ; owl:annotatedTarget "cartilagines bronchiales" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "A submucosa that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "EMAPA:37449" . [] oboInOwl:source "ncithesaurus:Bronchus_Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "UMLS:C0225601" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "bronchi submucosa" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:19074966" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "bronchial trunk submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "submucosa of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "submucosa of bronchial trunk" . _:genid120603 oboInOwl:hasDbXref "FMA:62653", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "tela submucosa bronchi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001694 . [] oboInOwl:hasDbXref "BTO:0002108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001957 ; owl:annotatedTarget "submucous layer of bronchi" . _:genid120605 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002187 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget _:genid121295 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "An epithelium that lines a terminal bronchiole." . [] oboInOwl:source "ncithesaurus:Terminal_Bronchiole_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "UMLS:C1179400" . _:genid120612 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "bronchiolus terminalis epithelial tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "bronchiolus terminalis epithelium" . _:genid120614 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "epithelial tissue of bronchiolus terminalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001849 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "epithelial tissue of terminal bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "epithelium of bronchiolus terminalis" . [] oboInOwl:hasDbXref "FMA:62794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "epithelium of terminal bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001958 ; owl:annotatedTarget "terminal bronchiole epithelial tissue" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0002357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001959 ; owl:annotatedTarget "The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies." . [] oboInOwl:source "ncithesaurus:Splenic_White_Pulp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001959 ; owl:annotatedTarget "UMLS:C0229686" . [] oboInOwl:hasDbXref "FMA:62805", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001959 ; owl:annotatedTarget "pulpa alba" . [] oboInOwl:hasDbXref "Wikipedia:White_pulp" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001959 ; owl:annotatedTarget "noduli lymphoidei splenici" . _:genid120627 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget obo:UBERON_0012069 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001839 . [] oboInOwl:hasDbXref "Wikipedia:Mucosa-associated_lymphoid_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." . [] oboInOwl:source "ncithesaurus:Mucosa-Associated_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "UMLS:C0599921" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000234 ; owl:annotatedTarget "Any cell capable of ingesting particulate matter via phagocytosis." . [] oboInOwl:hasDbXref "FMA:62819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "epithelio-lymphoid tissue" . [] oboInOwl:hasDbXref "GO:0048537" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "mucosa-associated lymphoid tissue" . [] oboInOwl:hasDbXref "GO:0048537" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "mucosal-associated lymphatic tissue" . [] oboInOwl:hasDbXref "GO:0048537" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001961 ; owl:annotatedTarget "mucosal-associated lymphoid tissue" . [] oboInOwl:hasDbXref "Wikipedia:Gut-associated_lymphoid_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001962 ; owl:annotatedTarget "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." . [] oboInOwl:source "ncithesaurus:Gut_Associated_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001962 ; owl:annotatedTarget "UMLS:C0596638" . (obo:UBERON_0001961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001963 ; owl:annotatedTarget _:genid121331 . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001963 ; owl:annotatedTarget "A diffuse collection of lymphpoid cells that participate in airway immune responses." . [] oboInOwl:source "ncithesaurus:Bronchus-Associated_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001963 ; owl:annotatedTarget "UMLS:C1179418" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001968 ; owl:annotatedTarget "Organism substance that is composed of sperm cells suspended in seminal fluid." . [] oboInOwl:source "ncithesaurus:Male_Genital_System_Fluid_or_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001968 ; owl:annotatedTarget "UMLS:C1518159" . [] oboInOwl:source "ncithesaurus:Semen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001968 ; owl:annotatedTarget "UMLS:C2756969" . [] oboInOwl:hasDbXref "BTO:0001230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001968 ; owl:annotatedTarget "sperm" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001969 ; owl:annotatedTarget "The liquid component of blood, in which erythrocytes are suspended." . _:genid120665 oboInOwl:hasDbXref "MA:0002501" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001969 ; owl:annotatedTarget "plasma" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 . [] oboInOwl:hasDbXref "FMA:62970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001969 ; owl:annotatedTarget "portion of plasma" . [] oboInOwl:source "ncithesaurus:Plasma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001969 ; owl:annotatedTarget "UMLS:C0032105" . _:genid120676 oboInOwl:composition "0.3% in humans" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001970 ; owl:annotatedTarget _:genid121360 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001750 . [] oboInOwl:hasDbXref "DOI:10.1002/cphy.c120027", "Wikipedia:Bile" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001970 ; owl:annotatedTarget "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." . [] oboInOwl:source "ncithesaurus:Bile" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001970 ; owl:annotatedTarget "UMLS:C0005388" . [] oboInOwl:hasDbXref "BTO:0000121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001970 ; owl:annotatedTarget "fel" . [] oboInOwl:hasDbXref "BTO:0000121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001970 ; owl:annotatedTarget "gall" . [] oboInOwl:hasDbXref "Wikipedia:Gastric_juice" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001971 ; owl:annotatedTarget "." . [] oboInOwl:source "ncithesaurus:Gastric_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001971 ; owl:annotatedTarget "UMLS:C0017133" . [] oboInOwl:hasDbXref "BTO:0000501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001971 ; owl:annotatedTarget "succus gastricus" . _:genid120688 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002499 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "A submucosa that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "gullet submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "oesophagus submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "submucosa of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "submucosa of oesophagus" . [] oboInOwl:hasDbXref "FMA:62997", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "tela submucosa (oesophagus)" . [] oboInOwl:hasDbXref "BTO:0002109" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "tela submucosa esophagi" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:19212411" . [] oboInOwl:hasDbXref "FMA:62997", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "tela submucosa oesophageae" . [] oboInOwl:hasDbXref "BTO:0002109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "submucous layer of esophagus" . [] oboInOwl:hasDbXref "BTO:0002109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001972 ; owl:annotatedTarget "tela submucosa oesophagi" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget _:genid121396 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "A lamina propria that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Esophageal_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "UMLS:C1707949" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "esophagus lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "esophagus lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "gullet lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "gullet lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "gullet lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria mucosa of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria mucosa of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria mucosa of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria mucosae of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria mucosae of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "lamina propria of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "oesophagus lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "oesophagus lamina propria mucosae" . [] oboInOwl:hasDbXref "EMAPA:26987" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001974 ; owl:annotatedTarget "esophageal lamina propria" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000235 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "A serous membrane that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "esophagus serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "gullet serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "gullet serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "oesophagus serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "serosa of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "serous membrane of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "serous membrane of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "serous membrane of oesophagus" . [] oboInOwl:hasDbXref "FMA:63057", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001975 ; owl:annotatedTarget "tunica serosa oesophageae" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:16213494", "PMID:1919437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000235 ; owl:annotatedTarget "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget _:genid121434 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000468" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "The epithelial layer that lines the luminal space of the esophagus." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001499" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO]" . [] oboInOwl:source "ncithesaurus:Esophageal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "UMLS:C1179544" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "epithelial tissue of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "epithelial tissue of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "epithelial tissue of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "epithelium of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "epithelium of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "esophagus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "gullet epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "gullet epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001976 ; owl:annotatedTarget "oesophagus epithelial tissue" . [] oboInOwl:hasDbXref "Wikipedia:Serum_(blood)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001977 ; owl:annotatedTarget "The portion of blood plasma that excludes clotting factors." . [] oboInOwl:source "ncithesaurus:Serum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001977 ; owl:annotatedTarget "UMLS:C0229671" . [] oboInOwl:hasDbXref "MESH:A07.231.432.952", "MP:0004125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001979 ; owl:annotatedTarget "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005315" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001979 ; owl:annotatedTarget "Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO]" . [] oboInOwl:source "ncithesaurus:Venule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001979 ; owl:annotatedTarget "UMLS:C0042520" . [] oboInOwl:hasDbXref "Wikipedia:Venule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001979 ; owl:annotatedTarget "venula" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget obo:UBERON_0003509 . [] oboInOwl:hasDbXref "GO:0014830" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002138" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget "Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO]" . _:genid120783 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010253" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget "Small, terminal branch of an artery which generally connects to capillaries.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000369 . [] oboInOwl:source "ncithesaurus:Arteriole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget "UMLS:C0003847" . _:genid120785 oboInOwl:hasDbXref "Wikipedia:Arteriole" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001980 ; owl:annotatedTarget "arteriola" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002435 . _:genid120787 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002045, obo:UBERON_0005382 . _:genid120789 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002216 ; owl:someValuesFrom obo:GO_0008015, obo:UBERON_0005383 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget _:genid121478 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget _:genid121480 . [] oboInOwl:source "GO:0072360" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget _:genid121484 . [] oboInOwl:hasDbXref "BTO:0001102", "Wikipedia:Blood_vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "A vessel through which blood circulates in the body." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001250" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011004" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "Any of the vessels through which blood circulates in the body.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001250" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX" . [] oboInOwl:hasDbXref "EMAPA:35993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "vascular element" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:19309105" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000236 ; owl:annotatedTarget obo:CL_0000945 . _:genid120800 oboInOwl:source "ncithesaurus:Blood_Vessel" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "UMLS:C0005847" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001869 . [] oboInOwl:hasDbXref "FMA:50722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "region of vascular tree organ" . [] oboInOwl:hasDbXref "FMA:50722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "vascular tree organ region" . [] oboInOwl:hasDbXref "Wikipedia:Blood_vessel" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001981 ; owl:annotatedTarget "vas sanguineum" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000236 ; owl:annotatedTarget "A lymphocyte of B lineage that is capable of B cell mediated immunity." . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Capillary", "https://github.com/obophenotype/uberon/issues/137" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001982 ; owl:annotatedTarget "Any of the smallest blood vessels connecting arterioles with venules." . _:genid120811 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010252" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001982 ; owl:annotatedTarget "Any of the tiny blood vessels connecting the arterioles to the venules.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002420 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001253" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001982 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . _:genid120813 oboInOwl:source "ncithesaurus:Capillary" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001982 ; owl:annotatedTarget "UMLS:C0935624" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006514 . (obo:UBERON_0001986 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000964 ] ) . ( ) . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget _:genid121512 . [] oboInOwl:hasDbXref "Wikipedia:Corneal_endothelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." . [] oboInOwl:source "ncithesaurus:Corneal_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget "UMLS:C0014259" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget "cornea endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget "endothelium of cornea" . [] oboInOwl:hasDbXref "Wikipedia:Corneal_endothelium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001985 ; owl:annotatedTarget "epithelium posterius corneae" . [] oboInOwl:source "FMA-text-def", "https://github.com/obophenotype/uberon/issues/225" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001986 ; owl:annotatedTarget obo:UBERON_0000487 . [] oboInOwl:possible_exception "UBERON:0001985" ; oboInOwl:source "FMA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001986 ; owl:annotatedTarget _:genid121526 . [] oboInOwl:hasDbXref "FMA:63916", "MESH:A10.272.491", "https://github.com/obophenotype/uberon/issues/225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001986 ; owl:annotatedTarget "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." . [] oboInOwl:source "ncithesaurus:Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001986 ; owl:annotatedTarget "UMLS:C0014257" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget _:genid121532 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget _:genid121534 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget _:genid121536 . [] oboInOwl:hasDbXref "Wikipedia:Placenta", "http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." . [] oboInOwl:hasDbXref "PMID:19782676" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget obo:CL_0000312 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001266" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/35054550 Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, O'Brien SJ, Molecular phylogenetics and the origins of placental mammals. Nature (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget "Phylogenetic analyses of the concatenated data set using maximum parsimony, maximum likelihood and distance based (neighbour joining) methods all converged on a nearly identical, well supported topology defining four principal eutherian lineages. The results affirm monophyly of traditional placental orders (except Artiodactyla and Insectivora), and also support some previously proposed, as well as new, superordinal clades.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Placenta" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget "UMLS:C0032043" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001987 ; owl:annotatedTarget "allantoic placenta" . [] oboInOwl:hasDbXref "Wikipedia:Feces", "http://www.merriam-webster.com/dictionary/feces" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "Portion of semisolid bodily waste discharged through the anus[MW,modified]." . [] oboInOwl:source "FMA:64183" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "Excretion in semisolid state processed by the intestine.[FMA]" . [] oboInOwl:source "ncithesaurus:Feces" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "UMLS:C0015733" . [] oboInOwl:hasDbXref "MESH:D018862" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000242 ; owl:annotatedTarget "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." . [] oboInOwl:hasDbXref "PMID:23285307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "piece of shit" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "portionem cacas" . [] oboInOwl:hasDbXref "Wikipedia:Cow_dung" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "cow dung" . [] oboInOwl:hasDbXref "Wikipedia:Cow_dung" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "cow pat" . [] oboInOwl:hasDbXref "Wikipedia:Fewmet" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "fewmet" . [] oboInOwl:hasDbXref "Wikipedia:Frass" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "frass" . [] oboInOwl:hasDbXref "Wikipedia:Guano" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "guano" . [] oboInOwl:hasDbXref "Wikipedia:Spraint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "spraint" . [] oboInOwl:hasDbXref "BTO:0000440" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001988 ; owl:annotatedTarget "excrement" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget obo:UBERON_0002418 . [] oboInOwl:source "VSAO-text-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget _:genid121560 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000094", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." . [] oboInOwl:source "FMA:64783" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000094" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.[VSAO]" . [] oboInOwl:source "ncithesaurus:Hyaline_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "UMLS:C0225362" . [] oboInOwl:hasDbXref "MA:0000109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "hyaline cartilage" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001994 ; owl:annotatedTarget "chondroid cartilage" . _:genid120868 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002495 ; owl:someValuesFrom obo:CL_0000138, obo:UBERON_0006240 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000103", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." . [] oboInOwl:source "Wikipedia:Fibrocartilage" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "A mixture of white fibrous tissue and cartilaginous tissue in various proportions. It owes its flexibility and toughness to the former of these constituents, and its elasticity to the latter. It is the only type of cartilage that contains type I collagen in addition to the normal type I[Wikipedia:Fibrocartilage]I" . [] oboInOwl:source "FMA:64784" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel without a well-defined perichondrium[FMA:64784]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000103" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns.[VSAO]" . [] oboInOwl:source "ncithesaurus:Fibrocartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "UMLS:C0684077" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "fibrocartilage tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001995 ; owl:annotatedTarget "stratified cartilage tissue" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget obo:UBERON_0011589 . _:genid120879 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget _:genid121578 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003849 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget _:genid121581 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000091", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "Cartilage tissue that is flexible and contains abundant elastic fibers." . _:genid120882 oboInOwl:source "FMA:64785" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which consists of elastic fibers[FMA:64785]." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0009616 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000091" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "Cartilage tissue that is flexible and contains abundant elastic fibers.[VSAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "MA has a distinct class for yellow" . [] oboInOwl:source "ncithesaurus:Elastic_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "UMLS:C0682559" . [] oboInOwl:hasDbXref "MA:0000107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "elastic cartilage" . [] oboInOwl:hasDbXref "VSAO:0000091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "elastic cartilage tissue" . [] oboInOwl:hasDbXref "Wikipedia:Elastic_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "yellow elastic cartilage" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "reticular cartilage" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0001996 ; owl:annotatedTarget "yellow cartilage" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002000 ; owl:annotatedTarget _:genid121597 . [] oboInOwl:hasDbXref "Wikipedia:Gluteal_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002000 ; owl:annotatedTarget "On of the muscles that make up the buttocks: the gluteus maximus muscle, gluteus medius muscle and gluteus minimus muscle." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002000 ; owl:annotatedTarget "FMA includes tensor fasciae latae and other buttock muscles. BTO def: Any one of three large skeletal muscles that form the buttock and move the thigh." . [] oboInOwl:source "ncithesaurus:Gluteal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002000 ; owl:annotatedTarget "UMLS:C1744702" . [] oboInOwl:hasDbXref "BTO:0000531" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002000 ; owl:annotatedTarget "gluteus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:19940987" . [] oboInOwl:hasDbXref "TAIR:sr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000293 ; owl:annotatedTarget "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002001 ; owl:annotatedTarget _:genid121607 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002001 ; owl:annotatedTarget "Any joint that connects a rib to another structure (or another rib). Examples: costochondral, costovertebral, interchondral, sternocostal joints." . [] oboInOwl:source "ncithesaurus:Joint_of_the_Rib" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002001 ; owl:annotatedTarget "UMLS:C1261194" . (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001322 ] ) . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "FMA", "MA", "NIF", "ZFA-isa-changed" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget _:genid121616 . [] oboInOwl:source "Wikipedia", "ZFA", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget _:genid121618 . [] oboInOwl:hasDbXref "GO:0048484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget "The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget "most sources classify this as autonomic, but in FMA it is placed directly under nervous system." . [] oboInOwl:source "BIRNLEX:1166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget "UMLS:C0206111" . [] oboInOwl:hasDbXref "EFO:0000895" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget "PNS - enteric" . [] oboInOwl:hasDbXref "EFO:0000895" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002005 ; owl:annotatedTarget "enteric PNS" . [] oboInOwl:hasDbXref "Wikipedia:Cortex_of_lymph_node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002006 ; owl:annotatedTarget "Peripheral portion of the lymph node, underneath the capsule[WP]." . [] oboInOwl:source "ncithesaurus:Lymph_Node_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002006 ; owl:annotatedTarget "UMLS:C0933402" . [] oboInOwl:hasDbXref "Wikipedia:Cortex_of_lymph_node" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002006 ; owl:annotatedTarget "cortex nodi lymphoidei" . (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029 ] ) . _:genid120932 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006222, obo:UBERON_0009744 . [] oboInOwl:hasDbXref "Wikipedia:Lymph_node#Medulla", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002007 ; owl:annotatedTarget "The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." . [] oboInOwl:hasDbXref "Wikipedia:Medulla_of_lymph_node" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002007 ; owl:annotatedTarget "medulla nodi lymphoidei" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "A plexus of nerves situated at the base of the heart that innervate the heart." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "EMAPA:37460" . [] oboInOwl:source "ncithesaurus:Cardiac_Nerve_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "UMLS:C0459528" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "autonomic nerve plexus of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "autonomic plexus of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "heart autonomic nerve plexus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "heart autonomic plexus" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002008 ; owl:annotatedTarget "plexus cardiacus" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000295 ; owl:annotatedTarget "A peptide hormone secreting cell that produces growth hormone, somatotropin." . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Thoracodorsal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002011 ; owl:annotatedTarget "The thoracodorsal artery is a branch of the subscapular artery. It travels inferiorly with the thoracodorsal nerve and supplies the latissimus dorsi. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002011 ; owl:annotatedTarget "EMAPA:37129" . [] oboInOwl:source "ncithesaurus:Thoracodorsal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002011 ; owl:annotatedTarget "UMLS:C0933449" . [] oboInOwl:hasDbXref "Wikipedia:Thoracodorsal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002011 ; owl:annotatedTarget "arteria thoracodorsalis" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget _:genid121670 . [] oboInOwl:source "EHDAA2", "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget _:genid121672 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget _:genid121674 . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_artery", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010221" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "Major artery which supplies blood to the lungs.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000982" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pulmonary+artery" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000982" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pulmonary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "UMLS:C0034052" . [] oboInOwl:hasDbXref "FMA:66326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "pulmonary arterial tree" . [] oboInOwl:hasDbXref "FMA:66326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "pulmonary arterial tree organ part" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "arteria pulmonalis" . [] oboInOwl:hasDbXref "FMA:66326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "pulmonary arterial subtree" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002012 ; owl:annotatedTarget "truncus pulmonalis" . ( ) . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002015 ; owl:annotatedTarget "The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage." . [] oboInOwl:source "ncithesaurus:Renal_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002015 ; owl:annotatedTarget "UMLS:C0227637" . [] oboInOwl:hasDbXref "FMA:66610", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002015 ; owl:annotatedTarget "capsula fibrosa renis" . [] oboInOwl:hasDbXref "FMA:66610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002015 ; owl:annotatedTarget "fibrous capsule of kidney" . [] oboInOwl:hasDbXref "GO:0072127" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002015 ; owl:annotatedTarget "renal capsule" . [] oboInOwl:hasDbXref "GO:0060577" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010521" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001133" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pulmonary+vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG]" . _:genid120997 oboInOwl:source "MP:0002726,MGI:cwg" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "the veins that return oxygenated blood from the lungs to the left atrium of the heart" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010225 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001133" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" . _:genid120999 oboInOwl:source "ncithesaurus:Pulmonary_Vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "UMLS:C0034090" ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0046883 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:2122710" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002016 ; owl:annotatedTarget "venae pulmonales" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002017 ; owl:annotatedTarget obo:UBERON_0001638 . [] oboInOwl:hasDbXref "BTO:0001792" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002017 ; owl:annotatedTarget "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." . [] oboInOwl:source "ncithesaurus:Portal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002017 ; owl:annotatedTarget "UMLS:C0032718" . [] oboInOwl:hasDbXref "FMA:66645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002017 ; owl:annotatedTarget "portal venous tree organ part" . [] oboInOwl:hasDbXref "BIRNLEX:812", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord." . [] oboInOwl:source "ISBN:080184780X", "XAO:0004214" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "A small motor nerve which emerges from the lateral wall of the medulla with the roots of the vagus nerve, and innervates a single pectoral suspensory muscle, the m.cucullaris." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000699" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "Cranial nerve that innervates the sternocleidomastoid and trapezius complex of muscles. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-1, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010476" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "Small motor nerve which innervates a single pectoral suspensory muscle, the m. cucullaris.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000699" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "Wikipedia:Cranial_nerves", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG]" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "FMA has distinct cranial and spinal parts - WP says 'Traditional descriptions of the accessory nerve divide it into two parts: a spinal part and a cranial part.[1] However, because the cranial component rapidly joins the vagus nerve, becoming an integral part of said nerve, modern descriptions often consider the cranial component to be part of the vagus nerve and not part of the accessory nerve proper.[2]" . [] oboInOwl:source "BIRNLEX:812", "ncithesaurus:Accessory_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "UMLS:C0000905" . [] oboInOwl:source "BIRNLEX:812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "UMLS:C1305777" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget obo:CL_0000586 . [] oboInOwl:hasDbXref "EHDAA2:0000106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "accessory XI" . [] oboInOwl:hasDbXref "BIRNLEX:812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "cranial nerve XI" . [] oboInOwl:hasDbXref "BIRNLEX:812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "eleventh cranial nerve" . [] oboInOwl:hasDbXref "FMA:6720", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "nervus accessorius [XI]" . [] oboInOwl:hasDbXref "FMA:6720", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "pars spinalis nervus accessorius" . [] oboInOwl:hasDbXref "FMA:6720", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "radix spinalis nervus accessorius" . [] oboInOwl:hasDbXref "FMA:6720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "spinal accessory nerve" . [] oboInOwl:hasDbXref "VHOG:0000699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "CN-XI" . [] oboInOwl:hasDbXref "BAMS:XIn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002019 ; owl:annotatedTarget "accessory spinal nerve" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000300 ; owl:annotatedTarget "A mature sexual reproductive cell having a single set of unpaired chromosomes." . [] oboInOwl:hasDbXref "Wikipedia:Gray_matter", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002197" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "EMAPA:37596" . [] oboInOwl:source "ncithesaurus:Gray_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "UMLS:C0018220" . [] oboInOwl:hasDbXref "FMA:67242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "gray matter of neuraxis" . [] oboInOwl:hasDbXref "AEO:0001012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "neuronal grey matter" . [] oboInOwl:hasDbXref "FMA:67242", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "substantia grisea" . [] oboInOwl:hasDbXref "ZFA:0001681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "gray mater" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002020 ; owl:annotatedTarget "grisea" . _:genid121044 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000164, obo:UBERON_0001003 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells." . [] oboInOwl:hasDbXref "Wikipedia:Malpighian_layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "Malpighian layer" . [] oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "rete Malphighii" . [] oboInOwl:hasDbXref "Wikipedia:Malpighian_layer" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "stratum Malpighi" . [] oboInOwl:source "ncithesaurus:Stratum_Basale" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "UMLS:C0221925" . [] oboInOwl:hasDbXref "FMA:67540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "basal cell layer of epidermis" . [] oboInOwl:hasDbXref "ZFA:0001180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "basal epidermal layer" . [] oboInOwl:hasDbXref "TAO:0001180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "epidermal basal stratum" . [] oboInOwl:hasDbXref "XAO:0000041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002025 ; owl:annotatedTarget "epidermis sensorial layer" . _:genid121056 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0013754 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000649 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015238 . _:genid121060 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030187, obo:UBERON_0001003 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance." . [] oboInOwl:hasDbXref "Wikipedia:Malpighian_layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "Malpighian layer" . [] oboInOwl:hasDbXref "Wikipedia:Malpighian" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "stratum Malpighii" . [] oboInOwl:source "ncithesaurus:Stratum_Spinosum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "UMLS:C0221924" . [] oboInOwl:hasDbXref "FMA:67542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "prickle cell layer of epidermis" . [] oboInOwl:hasDbXref "BTO:0000435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002026 ; owl:annotatedTarget "prickle cell layer" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget _:genid121779 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010597" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:CAM" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "The keratinized outermost layer of the epidermis, which is periodically shed.[AAO]" . [] oboInOwl:hasDbXref "BTO:0000344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "horny layer" . [] oboInOwl:source "ncithesaurus:Stratum_Corneum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "UMLS:C0221921" . [] oboInOwl:hasDbXref "FMA:67545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "horny layer of epidermis" . [] oboInOwl:hasDbXref "Wikipedia:Stratum_corneum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002027 ; owl:annotatedTarget "stratum corneum epidermidis" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget _:genid121789 . [] oboInOwl:notes "modified-source-relation" ; oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget _:genid121791 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget _:genid121794 . [] oboInOwl:hasDbXref "Wikipedia:Rhombencephalon", "ZFA:0000029", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "ABA", "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget obo:UBERON_0001891 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget obo:UBERON_0001894 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010150" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000029" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000029" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000070" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000307 ; owl:annotatedTarget obo:CL_0002202 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps" . [] oboInOwl:source "BIRNLEX:942", "ncithesaurus:Hind-Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "UMLS:C0035507" . [] oboInOwl:source "BIRNLEX:942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "UMLS:C1522180" . [] oboInOwl:source "BIRNLEX:942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002028 ; owl:annotatedTarget "neuronames:540" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:21761941" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000307 ; owl:annotatedTarget "An epithelial cell found in the trachea." . [] oboInOwl:hasDbXref "MP:0009492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "The simple columnar epithelial lining of the gall bladder." . [] oboInOwl:source "ncithesaurus:Gallbladder_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "UMLS:C1180206" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "epithelial tissue of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "epithelial tissue of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "epithelium of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "gall bladder epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "gallbladder epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002029 ; owl:annotatedTarget "gallbladder epithelium" . [] oboInOwl:source "Stedmans" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget _:genid121822 . [] oboInOwl:hasDbXref "FMA:67771", "Wikipedia:Nipple" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "FMA makes this part of the breast, whereas in MA it is part of the mammary gland -" . [] oboInOwl:source "ncithesaurus:Nipple" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "UMLS:C0028109" . [] oboInOwl:hasDbXref "MP:0009723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "papilla mammae" . [] oboInOwl:hasDbXref "MP:0009723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "thele" . [] oboInOwl:hasDbXref "MP:0009723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "thelium" . [] oboInOwl:hasDbXref "Wikipedia:Nipple" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002030 ; owl:annotatedTarget "papilla mammaria" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget _:genid121836 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "An epithelium that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchial_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "UMLS:C0599333" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "bronchi epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "bronchi epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "bronchial trunk epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "bronchial trunk epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "bronchus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "epithelial tissue of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "epithelial tissue of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "epithelial tissue of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "epithelium of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002031 ; owl:annotatedTarget "epithelium of bronchial trunk" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002032 ; owl:annotatedTarget _:genid121851 . [] oboInOwl:hasDbXref "FMA:67796" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002032 ; owl:annotatedTarget "Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple." . [] oboInOwl:source "ncithesaurus:Areola" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002032 ; owl:annotatedTarget "UMLS:C0222608" . [] oboInOwl:hasDbXref "Wikipedia:Areola" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002032 ; owl:annotatedTarget "areola mammae" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002032 ; owl:annotatedTarget "areolae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget obo:UBERON_0001135 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget _:genid121859 . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "A tiny smooth muscle that connects the hair follicle with the dermis." . [] oboInOwl:hasDbXref "FMA:67821", "MA:0000778" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pili" . [] oboInOwl:hasDbXref "EMAPA:26779", "MP:0010679" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pili muscle" . [] oboInOwl:hasDbXref "MA:0000778" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pili smooth muscle" . [] oboInOwl:hasDbXref "MP:0010679" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pilli" . [] oboInOwl:hasDbXref "MP:0010679" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pilli muscle" . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pilorum" . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arrector pilorum muscle of hair" . [] oboInOwl:hasDbXref "BTO:0005132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "arectores pilorum" . [] oboInOwl:hasDbXref "BTO:0005132" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "erector pili" . [] oboInOwl:hasDbXref "BTO:0005132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "erectores pilorum" . [] oboInOwl:hasDbXref "BTO:0005132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002033 ; owl:annotatedTarget "pilomotor muscle" . [] oboInOwl:hasDbXref "CL:0000737", "GOC:dph", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002036 ; owl:annotatedTarget "Muscle tissue that contains fibers that are divided by transverse bands into striations." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010762" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:CAM" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002036 ; owl:annotatedTarget "Voluntary muscle tissue arranged in bundles of fibers.[AAO]" . [] oboInOwl:source "ncithesaurus:Striated_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002036 ; owl:annotatedTarget "UMLS:C1331262" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget _:genid121881 . [] oboInOwl:source "NIF", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget _:genid121883 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget _:genid121885 . [] oboInOwl:hasDbXref "BTO:0000232", "ISBN:3764351209", "MESH:A08.186.211.132.810.428.200", "ZFA:0000100", "https://sourceforge.net/tracker/index.php?func=detail&aid=3291162&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget obo:NCBITaxon_117565 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget obo:UBERON_0001893 . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "ABA", "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget obo:UBERON_0002298 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010485" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000100" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000024" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG]" . [] oboInOwl:external_ontology "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem" . [] oboInOwl:hasDbXref "Wikipedia:Tentorium_cerebelli" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "infratentorial region" . [] oboInOwl:source "BIRNLEX:1489", "ncithesaurus:Cerebellum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "UMLS:C0007765" . [] oboInOwl:source "BIRNLEX:1489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "UMLS:C1268981" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget obo:CL_0000237 . [] oboInOwl:source "BIRNLEX:1489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "neuronames:643" . _:genid121181 oboInOwl:hasDbXref "FMA:67944" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "epencephalon-1" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010285 . [] oboInOwl:hasDbXref "NeuroNames:643" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "corpus cerebelli" . [] oboInOwl:hasDbXref "NeuroNames:643" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002037 ; owl:annotatedTarget "parencephalon" . [] oboInOwl:source "multiple" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget _:genid121904 . [] oboInOwl:source "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget _:genid121906 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget _:genid121908 . [] oboInOwl:hasDbXref "BIRNLEX:789" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget obo:CL_0000362 . [] oboInOwl:source "FMA:67947" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "Subdivision of the midbrain anterior to the midbrain tegmentum which contains darkly pigmented neurons[FMA][FMA:67947]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001573" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.336", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "(...) the substantia nigra first appears in reptiles and is best developed in primates.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:789", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "SN" . [] oboInOwl:source "BIRNLEX:789", "ncithesaurus:Substantia_Nigra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "UMLS:C0038590" . [] oboInOwl:source "BIRNLEX:789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "UMLS:C1269578" . [] oboInOwl:source "BIRNLEX:789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "neuronames:536" . [] oboInOwl:hasDbXref "NeuroNames:536" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "nucleus pigmentosus subthalamo-peduncularis" . [] oboInOwl:hasDbXref "Wikipedia:Substantia_nigra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "substancia nigra" . [] oboInOwl:hasDbXref "NeuroNames:536" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002038 ; owl:annotatedTarget "substantia nigra (Soemmerringi)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:dsd", "MESH:D015603", "PMID:15582983", "PMID:15749908", "PMID:19727116", "http://en.wikipedia.org/wiki/Keratinocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000312 ; owl:annotatedTarget "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Bronchial_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002040 ; owl:annotatedTarget "A systemic artery that supplies the lung with with oxygenated blood." . [] oboInOwl:source "ncithesaurus:Bronchial_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002040 ; owl:annotatedTarget "UMLS:C0006257" . [] oboInOwl:hasDbXref "Wikipedia:Bronchial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002040 ; owl:annotatedTarget "arteriae bronchiales" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000313 ; owl:annotatedTarget "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." . [] oboInOwl:hasDbXref "Wikipedia:Bronchial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002040 ; owl:annotatedTarget "rami bronchiales partis thoracicae aortae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget _:genid121939 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005258" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "The vascular endothelium that lines the lymph vessels.[TAO]" . [] oboInOwl:source "ncithesaurus:Lymphatic_Vessel_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "UMLS:C1180786" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "endothelium of lymph vessel" . [] oboInOwl:hasDbXref "FMA:68444" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "endothelium of lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "lymph vessel endothelium" . [] oboInOwl:hasDbXref "BTO:0004303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002042 ; owl:annotatedTarget "lymphatic endothelium" . _:genid121226 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000067 ; owl:someValuesFrom obo:GO_0006590, obo:UBERON_0003929 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget _:genid121951 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget _:genid121953 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget _:genid121955 . [] oboInOwl:hasDbXref "BTO:0001379", "Wikipedia:Thyroid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010544" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000418" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]" . [] oboInOwl:hasScope "NCBITaxon:32443" ; oboInOwl:source "Romer", "Wikipedia:Thyroid_gland#Other_animals" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes" . [] oboInOwl:hasScope "NCBITaxon:7746" ; oboInOwl:source "Romer", "Wikipedia:Thyroid_gland#Other_animals" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine)" . [] oboInOwl:hasScope "NCBITaxon:32523" ; oboInOwl:source "Romer", "Wikipedia:Thyroid_gland#Other_animals" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species" . [] oboInOwl:source "ncithesaurus:Thyroid_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "UMLS:C0040132" . [] oboInOwl:hasDbXref "Wikipedia:Thyroid" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002046 ; owl:annotatedTarget "glandula thyroidea" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget _:genid121967 . _:genid121241 oboInOwl:hasDbXref "Wikipedia:Pontine_raphe_nucleus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000349 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget obo:UBERON_0002148 . _:genid121243 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget obo:UBERON_0002267 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget obo:UBERON_0002587 . _:genid121245 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget obo:UBERON_0003004 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002600 . [] oboInOwl:source "BIRNLEX:1110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "UMLS:C0175423" . _:genid121247 oboInOwl:source "BIRNLEX:1110" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "neuronames:589" ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007613 . [] oboInOwl:hasDbXref "FMA:68875", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "raphe pontis" . [] oboInOwl:hasDbXref "NeuroNames:589" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "nucleus raphe pontis" . [] oboInOwl:hasDbXref "Wikipedia:Pontine_raphe_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "nucleus raphes pontis" . [] oboInOwl:hasDbXref "NeuroNames:589" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002047 ; owl:annotatedTarget "raphe (mediana pontina)" . [] oboInOwl:note "some species only have a single lung" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget _:genid121980 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget "Respiration organ that develops as an outpocketing of the esophagus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010567" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:SBH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget "Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000310" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210, DOI:10.1371/journal.pone.0024019 Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D, Gong Z, Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000317 ; owl:annotatedTarget obo:CL_0000151 . [] oboInOwl:source "ncithesaurus:Lung" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget "UMLS:C0024109" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002048 ; owl:annotatedTarget "pulmo" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002049 ; owl:annotatedTarget obo:UBERON_0000477 . [] oboInOwl:hasDbXref "ZFA:0005249" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002049 ; owl:annotatedTarget "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." . _:genid121267 oboInOwl:hasDbXref "FMA:69050" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002049 ; owl:annotatedTarget "vascular network" ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001994 . [] oboInOwl:hasDbXref "MESH:D012629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000317 ; owl:annotatedTarget "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." . [] oboInOwl:hasDbXref "BTO:0000174", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "Anatomical structure that is part of an embryo." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000138" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001105" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000178" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "in FMA embryo is_a embryonic structure" . [] oboInOwl:source "ncithesaurus:Embryonic_Structure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "UMLS:C0013948" . [] oboInOwl:hasDbXref "FBbt:00004208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "developing embryonic structure" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0003169" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "embryonic anatomical structure" . [] oboInOwl:hasDbXref "BTO:0000174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "embryonale Struktur" . [] oboInOwl:hasDbXref "ZFA:0001105" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002050 ; owl:annotatedTarget "embryonic structures" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget obo:UBERON_0004802 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget _:genid122017 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget "An epithelium that is part of a bronchiole [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchiole_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget "UMLS:C1181296" . [] oboInOwl:hasDbXref "BTO:0001866" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget "bronchiolar epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget "bronchiole epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002051 ; owl:annotatedTarget "epithelial tissue of bronchiole" . _:genid121295 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003893 [ a owl:Restriction ; owl:onProperty obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0002369 ] ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000158 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:2370482" . [] oboInOwl:hasDbXref "MP:0013565" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002052 ; owl:annotatedTarget "The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex." . [] oboInOwl:source "ncithesaurus:Adrenal_Gland_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002052 ; owl:annotatedTarget "UMLS:C1181304" . [] oboInOwl:hasDbXref "FMA:69087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002052 ; owl:annotatedTarget "capsule of adrenal gland" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_suprarenal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002056 ; owl:annotatedTarget "Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002056 ; owl:annotatedTarget "EMAPA:37088" . [] oboInOwl:source "ncithesaurus:Inferior_Suprarenal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002056 ; owl:annotatedTarget "UMLS:C0226334" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_suprarenal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002056 ; owl:annotatedTarget "arteria suprarenalis inferior" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002057 ; owl:annotatedTarget "An artery that supplies the diaphragm." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002057 ; owl:annotatedTarget "EMAPA:37108" . [] oboInOwl:source "ncithesaurus:Phrenic_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002057 ; owl:annotatedTarget "UMLS:C1181536" . [] oboInOwl:source "http://orcid.org/0000-0001-9114-8737", "inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget _:genid122056 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Ciliary_ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget "A parasympathetic ganglion located in the posterior orbit that contains preganglionic nerves and postganglionic neurons of the oculomotor nerve, connects to the Edinger-Westphal nucleus via the oculomotor nerve and the eye muscles via the short ciliary nerve." . [] oboInOwl:source "Wikipedia:Ciliary_ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget "The ciliary ganglion is a parasympathetic ganglion located in the posterior orbit. It measures 1-2 millimeters in diameter and contains approximately 2,500 neurons. Preganglionic axons from the Edinger-Westphal nucleus form synapses with these cells. The postganglionic axons run in the short ciliary nerves and innervate two eye muscles: the sphincter pupillae constricts the pupil, known as Miosis. The opposite, Mydriasis, is the dilation of the pupil. the ciliaris muscle contracts, releasing tension on the Zonular Fibers, making the lens more convex, also known as accommodation. Both of these muscles are involuntary - they are controlled by the autonomic nervous system. It is one of four parasympathetic ganglia of the head and neck.. [WP,unvetted][Wikipedia:Ciliary_ganglion]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000805" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.autneu.2010.03.002 Young HM, Cane KN, Anderson CR, Development of the autonomic nervous system: A comparative view. Autonomic Neuroscience : basic and clinical (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget "Little is known about the development of parasympathetic neurons apart from the ciliary ganglion in chicks. Although there are considerable gaps in our knowledge, some of the mechanisms controlling sympathetic and enteric neuron development appear to be conserved between mammals, avians and zebrafish.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "MA:0001136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget "ciliary ganglion" . _:genid121331 oboInOwl:hasDbXref "Wikipedia:Ciliary_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002058 ; owl:annotatedTarget "ganglion ciliare" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001957 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget _:genid122067 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "The ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands." . [] oboInOwl:source "ncithesaurus:Submandibular_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "UMLS:C0229063" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20054144" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000322 ; owl:annotatedTarget "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "mandibular ganglion" . [] oboInOwl:hasDbXref "BTO:0001318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "Blandin`s ganglion" . [] oboInOwl:hasDbXref "BTO:0001318", "Wikipedia:Submandibular_ganglion" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "ganglion submandibulare" . [] oboInOwl:hasDbXref "MA:0002470", "https://sourceforge.net/tracker/index.php?func=detail&aid=2979467&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "lingual ganglion" . [] oboInOwl:hasDbXref "MA:0002470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "maxillary ganglion" . [] oboInOwl:hasDbXref "MA:0002470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002059 ; owl:annotatedTarget "submaxillary ganglion" . [] oboInOwl:source "FMA", "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002060 ; owl:annotatedTarget _:genid122078 . [] oboInOwl:hasDbXref "Wikipedia:Femoral_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002060 ; owl:annotatedTarget "The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010222" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002060 ; owl:annotatedTarget "Artery which supplies blood via branches to the hindlimbs.[AAO]" . [] oboInOwl:source "ncithesaurus:Femoral_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002060 ; owl:annotatedTarget "UMLS:C0015801" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000325 ; owl:annotatedTarget "A cell that is specialised to accumulate a particular substance(s)." . [] oboInOwl:hasDbXref "Wikipedia:Femoral_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002060 ; owl:annotatedTarget "arteria femoralis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget obo:UBERON_0002050 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget _:genid122086 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget _:genid122088 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget _:genid122090 . [] oboInOwl:hasDbXref "Wikipedia:Truncus_arteriosus_(embryology)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget "assume spelling error for ncit" . [] oboInOwl:source "ncithesaurus:Trancus_Arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002061 ; owl:annotatedTarget "UMLS:C1519589" . _:genid121360 oboInOwl:source "GO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget obo:UBERON_0003104 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_16990 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget _:genid122097 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget _:genid122099 . [] oboInOwl:source "Wikipedia", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget _:genid122101 . [] oboInOwl:hasDbXref "GO:0003197", "Wikipedia:Atrioventricular_cushions", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001317" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001317" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000932" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/35047564 Stainier DYR, Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics (2001) Figure 3", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Endocardial_cushion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "atrioventricular cushion" . [] oboInOwl:hasDbXref "PMID:15797462" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "cardiac cushion" . [] oboInOwl:hasDbXref "EHDAA2:0000434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "endocardial cushion tissue" . [] oboInOwl:hasDbXref "FMA:70302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "atrioventricular canal cushion" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002062 ; owl:annotatedTarget "endocardial cushions" . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget _:genid122112 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget _:genid122114 . [] oboInOwl:hasDbXref "PMID:20735616", "Wikipedia:Sinus_venosus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000154" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "Heart region collecting blood from the paired common cardinal veins and delivering to the atrium. One of four components of the heart. The sinus venosus also acts as a pacemaker and is the first to contract. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010505" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "Part of the circulatory system which receives blood from the systemic veins and contracts to pump the blood into the atrium of the heart.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000177" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" . [] oboInOwl:source "ZFA:0000154" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "In zebrafish, the sinus venosus also acts as a pacemaker and is the first to contract" . [] oboInOwl:hasDbXref "ZFA:0000154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "inflow tract" . [] oboInOwl:source "ncithesaurus:Sinus_Venarum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "UMLS:C0225857" . [] oboInOwl:source "ncithesaurus:Sinus_Venosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "UMLS:C0231084" . [] oboInOwl:hasDbXref "Wikipedia:Sinus_venosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "sinus venarum" . [] oboInOwl:hasDbXref "Wikipedia:Sinus_venosus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "sinus venosus cordis" . [] oboInOwl:hasDbXref "Wikipedia:Sinus_venosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "venarum" . [] oboInOwl:hasDbXref "Wikipedia:Sinus_venosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "venarum sinus" . [] oboInOwl:hasDbXref "Wikipedia:Sinus_venosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002063 ; owl:annotatedTarget "venosus" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Posterior_cardinal_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "One of two paired cardinal veins that return blood from the body of the embryo[Kardong]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000477" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "Continuation of the caudal vein cranial to the anal pore. The cardinal vein splits into a pair of vessels in the cranial trunk, just caudal to the radix of the aorta. The posterior cardinals each empty into the common cardinal vein. [TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010511" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "Either of two veins which receive blood as an alternate route from the kidneys.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000477" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "relationship loss: part_of axial vasculature (TAO:0001073)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000477" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "relationship loss: part_of cardinal system (TAO:0000096)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000111" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.462", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "In primitive vertebrates, the basic early embryonic pattern is retained, and blood from anterior and posterior systemic tissues is returned in anterior and posterior cardinal veins, both pairs of veins uniting in common cardinal veins near the heart. In derived vertebrates, the cardinals appear but usually persist only in the embryo, being functionally replaced by alternative adult vessels, the precava and postcava (anterior and posterior venae cavae).[well established][VHOG]" . _:genid121396 oboInOwl:source "WP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "join with the corresponding right and left cardinal veins to form the left common cardinal veins, which empty in the sinus venosus. Most of the posterior cardinal veins regress, what remains of them forms the renal segment of the inferior vena cava and the common iliac veins. Later in the development stages, the posterior cardinal veins are replaced by the subcardinal and supracardinal veins. The subcardinal veins form part of the inferior vena cava, renal veins and gonadal veins. The supracardinal veins form part of the inferior vena cava, the intercostal veins, hemiazygos vein and azygos vein" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002469 . [] oboInOwl:source "ncithesaurus:Posterior_Cardinal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "UMLS:C0231087" . [] oboInOwl:hasDbXref "http://www.embryology.ch/anglais/pcardio/venen01.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "inferior cardinal vein" . [] oboInOwl:hasDbXref "AAO:0010511", "FMA:70314", "Wikipedia:Posterior_cardinal_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002065 ; owl:annotatedTarget "postcardinal vein" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:24027187" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget obo:UBERON_0004923 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget _:genid122142 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget _:genid122148 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget _:genid122151 . [] oboInOwl:hasDbXref "Wikipedia:Dermis", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." . [] oboInOwl:hasDbXref "MESH:A16.254.600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000333 ; owl:annotatedTarget "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001119" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000108" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Dermis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "UMLS:C0011646" . [] oboInOwl:hasDbXref "BTO:0000294", "Wikipedia:Dermis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "corium" . [] oboInOwl:hasDbXref "BTO:0000294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002067 ; owl:annotatedTarget "cutis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget _:genid122160 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget _:genid122163 . [] oboInOwl:hasDbXref "MP:0011852", "MP:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget "A fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies[MP]." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:5025404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000335 ; owl:annotatedTarget "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000735" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/urachus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget "A fetal canal connecting the bladder with the allantois, persisting throughout life as a cord (median umbilical ligament). [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Urachus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002068 ; owl:annotatedTarget "UMLS:C0041916" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002069 ; owl:annotatedTarget "The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis." . [] oboInOwl:source "ncithesaurus:Stratum_Granulosum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002069 ; owl:annotatedTarget "UMLS:C0221923" . [] oboInOwl:hasDbXref "FMA:70344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002069 ; owl:annotatedTarget "granular layer of epidermis" . [] oboInOwl:hasDbXref "BTO:0000361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002069 ; owl:annotatedTarget "stratum granulosum" . _:genid121434 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926, obo:UBERON_0002469 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget obo:UBERON_0004923 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget _:genid122179 . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget _:genid122185 . [] oboInOwl:hasDbXref "Wikipedia:Hypodermis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001136" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]" . [] oboInOwl:source "FMA:70544" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "EMAPA:37505" . [] oboInOwl:source "ncithesaurus:Subcutis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "UMLS:C0278403" . [] oboInOwl:hasDbXref "BTO:0004525" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "sub-tegumental tissue" . [] oboInOwl:hasDbXref "Wikipedia:Hypodermis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "subcutaneous tissue" . [] oboInOwl:hasDbXref "BTO:0004525" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "subtegumental tissue" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "superficial fascia" . [] oboInOwl:hasDbXref "Wikipedia:Hypodermis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002072 ; owl:annotatedTarget "tela subcutanea" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget _:genid122198 . [] oboInOwl:source "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget _:genid122200 . [] oboInOwl:hasDbXref "Wikipedia:Hair_follicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget "A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001268" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-4431998051 Morioka K, Hair follicle: differentiation under the electron microscope, An atlas (2005) p.3", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget "The earliest reliable record of hair is found in a fossil of the Paleocene period, in which the structure of hair cuticles is preserved. Its appearance suggests that the complicated structure of the hair follicle, closely similar to that of present-day mammals, had already appeared at this time.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Hair_Follicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget "UMLS:C0221971" . [] oboInOwl:hasDbXref "Wikipedia:Hair_follicle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002073 ; owl:annotatedTarget "folliculus pili" . [] oboInOwl:source "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002074 ; owl:annotatedTarget _:genid122208 . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002074 ; owl:annotatedTarget "The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla." . [] oboInOwl:source "ncithesaurus:Shaft_of_the_Hair" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002074 ; owl:annotatedTarget "UMLS:C0221961" . [] oboInOwl:hasDbXref "BTO:0004672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002074 ; owl:annotatedTarget "scapus pili" . [] oboInOwl:hasDbXref "BTO:0001491", "Wikipedia:Viscus", "https://github.com/obophenotype/mouse-anatomy-ontology/issues/14" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010386" ; oboInOwl:ontology "AAO" ; oboInOwl:source "BTO:0001491" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs." . [] oboInOwl:source "ncithesaurus:Viscera" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "UMLS:C0042779" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0002201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "visceral organ" . [] oboInOwl:hasDbXref "MA:0000019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "visceral organ system" . [] oboInOwl:hasDbXref "BTO:0001491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "splanchnic tissue" . [] oboInOwl:hasDbXref "BTO:0001491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002075 ; owl:annotatedTarget "visceral tissue" . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget obo:CL_0000150 . _:genid121480 oboInOwl:hasDbXref "MGI:llw2", "MP:0003810" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002076 ; owl:annotatedTarget "Smooth and glossy outer protective cell layer of hair shaft." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007500 . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002077 ; owl:annotatedTarget "A cortex that is part of a hair [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002077 ; owl:annotatedTarget "coat hair cortex" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002077 ; owl:annotatedTarget "coat/hair cortex" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002077 ; owl:annotatedTarget "cortex of coat hair" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002077 ; owl:annotatedTarget "cortex of coat/hair" . [] oboInOwl:hasDbXref "Wikipedia:Right_atrium", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." . [] oboInOwl:source "FMA:7096" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000328" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Right_Atrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "UMLS:C0225844" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:2494044" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.britannica.com/EBchecked/topic/6405/adrenal-gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." . [] oboInOwl:hasDbXref "MA:0000075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "heart right atrium" . [] oboInOwl:hasDbXref "VHOG:0000328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "right atrium" . [] oboInOwl:hasDbXref "Wikipedia:Right_atrium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002078 ; owl:annotatedTarget "atrium dextrum" . [] oboInOwl:hasDbXref "Wikipedia:Left_atrium", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." . [] oboInOwl:source "FMA:7097" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA]" . [] oboInOwl:hasDbXref "FMA:69262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000336 ; owl:annotatedTarget "medullary chromaffin cell of adrenal gland" . [] oboInOwl:source "XAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "The chamber of the heart that receives blood from the lungs[XAO:EJS]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000369" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" . _:genid121512 oboInOwl:source "ncithesaurus:Left_Atrium" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "UMLS:C0225860" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:hasDbXref "Wikipedia:Left_atrium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "atrium sinistrum" . [] oboInOwl:hasDbXref "MA:0000074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "heart left atrium" . [] oboInOwl:hasDbXref "VHOG:0000369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002079 ; owl:annotatedTarget "left atrium" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000339 ; owl:annotatedTarget "An early neural cell developing from the early ependymal cell of the neural tube." . [] oboInOwl:source "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget _:genid122272 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget _:genid122274 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "A cardiac ventricle that is in the right side of the heart." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000717" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG]" . [] oboInOwl:source "ncithesaurus:Right_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "UMLS:C0225883" . _:genid121526 oboInOwl:hasDbXref "FMA:7098" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "right ventricle" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "EMAPA:17340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "right cardiac ventricle" . [] oboInOwl:hasDbXref "Wikipedia:Right_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002080 ; owl:annotatedTarget "ventriculus dexter" . [] oboInOwl:hasDbXref "Wikipedia:Heart_atrium", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "Cardiac chamber in which blood enters the heart." . _:genid121532 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000471" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "One of four heart chambers.[TAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000995 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010246" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO]" . _:genid121534 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000175" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003124 . [] oboInOwl:source "ncithesaurus:Cardiac_Atrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "UMLS:C0018792" . _:genid121536 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "atria" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004340 . [] oboInOwl:hasDbXref "ZFA:0000471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "atrium" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "cardiac atria" . [] oboInOwl:hasDbXref "BTO:0000903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002081 ; owl:annotatedTarget "atrial tissue" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget _:genid122294 . [] oboInOwl:hasDbXref "Wikipedia:Ventricle_(heart)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget "Cardiac chamber through which blood leaves the heart." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010249" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget "A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000009" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget "One of four heart chambers.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000435" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cardiac_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002082 ; owl:annotatedTarget "UMLS:C0018827" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget _:genid122307 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "A cardiac ventricle that is in the left side of the heart." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000718" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000718" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1126/science.1190181 Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L, Early chordate origins of the vertebrate second heart field. Science (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Left_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "UMLS:C0225897" . [] oboInOwl:hasDbXref "FMA:7101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "left ventricle" . [] oboInOwl:hasDbXref "Wikipedia:Left_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002084 ; owl:annotatedTarget "ventriculus sinister cordis" . _:genid121560 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002099 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002078 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002079 ] ) ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:GO_0005585 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002085 ; owl:annotatedTarget "A cardiac septum that divides the left and right atria of the heart." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000385" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/interatrial+septum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002085 ; owl:annotatedTarget "The partition separating the right and left atria of the heart. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000385" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002085 ; owl:annotatedTarget "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Interatrial_Septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002085 ; owl:annotatedTarget "UMLS:C0225836" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget _:genid122325 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget _:genid122329 . [] oboInOwl:hasDbXref "Wikipedia:Atrioventricular_canal", "ZFA:0001315", "https://github.com/obophenotype/uberon/issues/38" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "The part of the heart connecting the atrium to the cardiac ventricle[ZFA]. In the developing heart, the constriction between the atrium and ventricle constitutes the atrial canal, and indicates the site of the future atrioventricular valves[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001473" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/atrioventricular+canal" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "The canal connecting the primitive atrium and ventricle in fishes and amniotes embryo. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001473" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ddmec.2004.08.004 Haramis APG, Clevers HC, Holehearted: genetic approaches to congenital cardiac valve malformations. Drug Discovery Today: Disease Mechanisms (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "The heart is the first organ to form and function in a vertebrate. (...) Septation of the AV canal is initiated with the formation of inferior and superior endocardial cushions in response to signaling from the overlying myocardium. (...) Analysis of zebrafish mutants with cardiovascular defects uncovered a previously unexpected level of conservation between zebrafish and human cardiovascular physiology.[uncertain][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "this is a lumen in EHDAA2" . _:genid121578 oboInOwl:hasDbXref "ZFA:0001315" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "AVC" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0071953 . [] oboInOwl:hasDbXref "Wikipedia:Atrial_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "atrial canal" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000347 ; owl:annotatedTarget "A cell of the sclera of the eye." . [] oboInOwl:hasDbXref "EHDAA2:0000152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "atrio-ventricular canal" . _:genid121581 oboInOwl:hasDbXref "Wikipedia:Atrioventricular_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "canalis atrioventricularis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005863 . [] oboInOwl:hasDbXref "EMAPA:16546" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002087 ; owl:annotatedTarget "ependymal canal" . [] oboInOwl:source "FMA/obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002089 ; owl:annotatedTarget _:genid122344 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=97559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002089 ; owl:annotatedTarget "Companion vein of the thoracodorsal artery, draining the apical part of the latissimus dorsi and merging with the circumflex scapular vein to form a subscapular vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002089 ; owl:annotatedTarget "EMAPA:37198" . [] oboInOwl:hasDbXref "ZFA:0000317", "https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957", "https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000093" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000034" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000317" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO]" . _:genid121597 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000317" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1186/1742-9994-8-4 Schilling N, Evolution of the axial system in craniates: morphology and function of the perivertebral musculature. Frontiers in Zoology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . [] oboInOwl:hasDbXref "FMA:71221", "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "axial skeleton" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002090 ; owl:annotatedTarget "EMAPA:37721" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27291853" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "Wikipedia:Appendicular_skeleton", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000076" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000027" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000747" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO]" . _:genid121607 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014478 . [] oboInOwl:source "ncithesaurus:Appendicular_Skeleton" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "UMLS:C0222646" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/59" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "entire appendicular skeleton" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "paired fin skeleton" . [] oboInOwl:hasDbXref "Wikipedia:Appendicular_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002091 ; owl:annotatedTarget "skeleton appendiculare" . _:genid121616 oboInOwl:hasDbXref "MP:0009025" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002410 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000270" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "The outermost and densest membrane of the three mammalian meninges covering the brain and spinal cord. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" . _:genid121618 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000270" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005428 . [] oboInOwl:source "ncithesaurus:Cerebral_Dura_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "UMLS:C0459393" . [] oboInOwl:hasDbXref "FMA:71236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "cranial dura mater" . [] oboInOwl:hasDbXref "FMA:71236", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002092 ; owl:annotatedTarget "dura mater cranialis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "A dura mater that is part of a spinal cord [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000411" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "The outermost and densest membrane of the three mammalian meninges covering the brain and spinal cord. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000411" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Spinal_Cord_Dura_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "UMLS:C0228124" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "dura mater of neuraxis of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002093 ; owl:annotatedTarget "spinal cord dura mater of neuraxis" . [] oboInOwl:hasDbXref "FMA:7133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000386" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/interventricular+septum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "The partition separating the right and left ventricles of the heart. [TFD][VHOG]" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000348 ; owl:annotatedTarget "A structural cell that is part of optic choroid." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000386" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.430", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG]" . [] oboInOwl:source "ISBN:0124020607" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999)" . [] oboInOwl:source "ncithesaurus:Interventricular_Septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "UMLS:C0225870" . [] oboInOwl:hasDbXref "MA:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "heart interventricular septum" . [] oboInOwl:hasDbXref "MA:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "heart ventricular septum" . [] oboInOwl:hasDbXref "BTO:0002483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "interventricular septum of heart" . [] oboInOwl:hasDbXref "BTO:0002483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "interventriculare cordis" . [] oboInOwl:hasDbXref "Wikipedia:Interventricular_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "intraventricular septum" . [] oboInOwl:hasDbXref "Wikipedia:Interventricular_septum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "s. interventriculare cordis" . [] oboInOwl:hasDbXref "Wikipedia:Interventricular_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "septum inferius" . [] oboInOwl:hasDbXref "Wikipedia:Interventricular_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "septum membranaceum" . [] oboInOwl:hasDbXref "MA:0000085", "Wikipedia:Interventricular_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002094 ; owl:annotatedTarget "ventricular septum" . [] oboInOwl:hasDbXref "FMA:7144", "Wikipedia:Mesentery", "Wikipedia:Mesentery#Mesentery_.28general.29", "https://github.com/obophenotype/uberon/issues/85" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002095 ; owl:annotatedTarget "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002095 ; owl:annotatedTarget "in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery." . [] oboInOwl:source "ncithesaurus:Mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002095 ; owl:annotatedTarget "UMLS:C0025474" . [] oboInOwl:hasDbXref "Wikipedia:Mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002095 ; owl:annotatedTarget "generic mesentery" . [] oboInOwl:hasDbXref "Wikipedia:Mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002095 ; owl:annotatedTarget "mesentery (generic)" . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002097 ; owl:annotatedTarget _:genid122416 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002097 ; owl:annotatedTarget "The organ covering the body that consists of the dermis and epidermis." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002097 ; owl:annotatedTarget "MA uses the term skin to refer to what is called here: zone of skin" . [] oboInOwl:source "ncithesaurus:Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002097 ; owl:annotatedTarget "UMLS:C1123023" . _:genid121670 oboInOwl:hasDbXref "MESH:A07.541.459" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002061 . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this" . _:genid121672 oboInOwl:source "ncithesaurus:Heart_Septum" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "UMLS:C0018819" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003123 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "cardiac septa" . _:genid121674 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "heart septa" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005339 . [] oboInOwl:hasDbXref "XAO:0004141" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002099 ; owl:annotatedTarget "spiral septa" . [] oboInOwl:hasDbXref "TAO:0001115", "UBERONREF:0000006", "Wikipedia:Torso" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget obo:UBERON_0000026 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010339" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001115" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]" . [] oboInOwl:source "ncithesaurus:Trunk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "UMLS:C0460005" . [] oboInOwl:hasDbXref "XAO:0000054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "trunk region" . [] oboInOwl:hasDbXref "BTO:0001493" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002100 ; owl:annotatedTarget "Rumpf" . [] oboInOwl:specialization_within "Sarcopterygians" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget obo:UBERON_0004708 . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010336" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "Organism subdivision that has as its parts the jointed appendages used for locomotion and manipulation.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000336" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Limb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "UMLS:C0015385" . [] oboInOwl:hasDbXref "FMA:24875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "free limb" . [] oboInOwl:hasDbXref "MAT:0000090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "limb sensu Vertebrata" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "flipper" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002101 ; owl:annotatedTarget "extremities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27334436" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000205" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "Upper limb, which connects the manus with the pectoral girdle.[AAO]" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D014327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000351 ; owl:annotatedTarget "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "note that this corresponds to FMA:'free upper limb' (a limb segment), NOT FMA:'upper limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb" . [] oboInOwl:source "ncithesaurus:Upper_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "UMLS:C1140618" . [] oboInOwl:hasDbXref "FMA:24878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "free part of upper limb" . [] oboInOwl:hasDbXref "FMA:24878", "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "free upper limb" . [] oboInOwl:hasDbXref "FMA:7183", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "membrum superius" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002102 ; owl:annotatedTarget "pectoral flipper" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000352 ; owl:annotatedTarget "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." . [] oboInOwl:hasDbXref "UBERONREF:0000003", "Wikipedia:Hindlimb", "Wikipedia:Lower_limb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000219" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "Lower limb, which connects the pes with the pelvic girdle.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000337" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "note that this corresponds to FMA:'free lower limb' (a limb segment), NOT 'lower limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb. Note that AAO class probably refers to skeleton" . [] oboInOwl:source "ncithesaurus:Lower_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "UMLS:C0023216" . [] oboInOwl:source "ncithesaurus:Hind_Limb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "UMLS:C1522391" . [] oboInOwl:hasDbXref "MESH:D001756" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000353 ; owl:annotatedTarget "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." . [] oboInOwl:hasDbXref "FMA:24879", "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "free lower limb" . [] oboInOwl:hasDbXref "VSAO:0000150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "hind-limb" . [] oboInOwl:hasDbXref "FMA:7184", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "membrum inferius" . [] oboInOwl:hasDbXref "FMA:24879" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "free part of lower limb" . [] oboInOwl:hasDbXref "Wikipedia:Lower_limb" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002103 ; owl:annotatedTarget "membrum inferius" . [] oboInOwl:hasDbXref "NIFSTD:FMAID_7191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002104 ; owl:annotatedTarget "The sensory system subserving the sense of vision." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000632" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002104 ; owl:annotatedTarget "The sensory system used for sight.[AAO]" . [] oboInOwl:source "ncithesaurus:Visual_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002104 ; owl:annotatedTarget "UMLS:C0587900" . [] oboInOwl:hasDbXref "BILA:0000140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002104 ; owl:annotatedTarget "photosensory system" . [] oboInOwl:hasDbXref "ZFA:0001138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002105 ; owl:annotatedTarget "Sensory system responsible for the perception of spatial orientation and auditory stimuli." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000631" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002105 ; owl:annotatedTarget "The sensory system used for balance and hearing.[AAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002105 ; owl:annotatedTarget "EMAPA:37985" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget _:genid122505 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "The organ that functions to filter blood and to store red corpuscles and platelets." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010395" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BMZ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "An organ involved in red blood cell filtration and immune response.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000120" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" . [] oboInOwl:source "PMID:20959416" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)" . [] oboInOwl:source "ncithesaurus:Spleen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "UMLS:C0037993" . [] oboInOwl:hasDbXref "Wikipedia:Spleen" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002106 ; owl:annotatedTarget "lien" . [] oboInOwl:source "BTO", "EHDAA2", "GO-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122517 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122519 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122521 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122523 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122525 . [] oboInOwl:source "ZFA-weakened" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122528 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122530 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122532 . [] oboInOwl:source "http://www.stembook.org/node/512" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget _:genid122534 . [] oboInOwl:hasDbXref "BTO:0000759", "Wikipedia:Liver" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010111" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "Organ which secretes bile and participates in formation of certain blood proteins.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010111" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000257" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.526, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function." . [] oboInOwl:source "ncithesaurus:Liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "UMLS:C0023884" . [] oboInOwl:hasDbXref "Wikipedia:Liver" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "iecur" . _:genid121779 oboInOwl:hasDbXref "Wikipedia:Liver" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002107 ; owl:annotatedTarget "jecur" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002153 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000355 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:order "2" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Small_intestine" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001323" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget "The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000055" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Small_Intestine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget "UMLS:C0021852" . [] oboInOwl:hasDbXref "BTO:0000651", "Wikipedia:Small_intestine" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002108 ; owl:annotatedTarget "intestinum tenue" . (obo:UBERON_0034925 [ a owl:Restriction ; owl:onClass obo:UBERON_0000003 ; owl:onProperty obo:RO_0002351 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) . [] oboInOwl:hasDbXref "PMID:18282570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000355 ; owl:annotatedTarget "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." . ( ) . _:genid121794 oboInOwl:hasDbXref "Wikipedia:Nares" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002109 ; owl:annotatedTarget "Pair of nostrils." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007277 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002109 ; owl:annotatedTarget "this is a 'set of anatomical planes' in FMA" . [] oboInOwl:hasDbXref "FMA:72005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002109 ; owl:annotatedTarget "set of nares" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27345710" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget obo:UBERON_0018707 . [] oboInOwl:source "MA", "ZFA", "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget _:genid122569 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget _:genid122573 . [] oboInOwl:hasDbXref "Wikipedia:Gallbladder" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "An organ that aids digestion and stores bile produced by the liver[WP]." . [] oboInOwl:source "GOC:mr", "ISBN:9781840761122" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget obo:NCBITaxon_8801 . [] oboInOwl:source "GOC:mr", "ISBN:9781840761122" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget obo:NCBITaxon_8930 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000221" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010114" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010114" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000221" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/(SICI)1097-0029(19970915)38:6<571::AID-JEMT3>3.0.CO;2-I Oldham-Ott CK, Gilloteaux J, Comparative morphology of the gallbladder and biliary tract in vertebrates: Variation in structure, homology in function and gallstones. Microscopy research and technique (1997)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Gallbladder" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "UMLS:C0016976" . [] oboInOwl:hasDbXref "WikipediaVersioned:Gallbladder&oldid=1092217922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "cholecyst" . [] oboInOwl:hasDbXref "Wikipedia:Gallbladder" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "vesica biliaris" . [] oboInOwl:hasDbXref "Wikipedia:Gallbladder" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002110 ; owl:annotatedTarget "vesica fellea" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget obo:UBERON_0001135 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." . _:genid121822 oboInOwl:source "ncithesaurus:Artery_Smooth_Muscle_Tissue" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget "UMLS:C1706851" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008425 . [] oboInOwl:hasDbXref "BTO:0000087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget "arterial smooth muscle" . [] oboInOwl:hasDbXref "FMA:72024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget "smooth muscle of artery" . [] oboInOwl:hasDbXref "BTO:0000087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002111 ; owl:annotatedTarget "arterial smooth muscle cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "esophagus involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "esophagus non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "esophagus smooth muscle tissue" . _:genid121836 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "gullet involuntary muscle" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002209 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "gullet non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "gullet smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "gullet smooth muscle tissue" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "involuntary muscle of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "involuntary muscle of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "involuntary muscle of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "non-striated muscle of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "non-striated muscle of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "non-striated muscle of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "oesophagus involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "oesophagus non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "oesophagus smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "smooth muscle of gullet" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000358 ; owl:annotatedTarget "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "smooth muscle of oesophagus" . _:genid121851 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "smooth muscle tissue of esophagus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "smooth muscle tissue of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002112 ; owl:annotatedTarget "smooth muscle tissue of oesophagus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget _:genid122626 . _:genid121859 oboInOwl:evidence "definitional" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget _:genid122629 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011932 . [] oboInOwl:hasDbXref "Wikipedia:Kidney", "http://anatomy.uams.edu/anatomyhtml/kidney.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget "A paired organ of the urinary tract which has the production of urine as its primary function." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000250" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget "One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO]" . [] oboInOwl:source "ncithesaurus:Kidney" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget "UMLS:C0022646" . [] oboInOwl:hasDbXref "Wikipedia:Reniculate_kidney" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002113 ; owl:annotatedTarget "reniculate kidney" . [] oboInOwl:order "3" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "ISBN:0815318960", "Wikipedia:Duodenum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000052" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:hasScope "NCBITaxon:32443" ; oboInOwl:source "Wikipedia:Duodenum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum." . [] oboInOwl:hasScope "NCBITaxon:9606" ; oboInOwl:source "Wikipedia:Duodenum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz." . [] oboInOwl:source "ncithesaurus:Duodenum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "UMLS:C0013303" . [] oboInOwl:hasDbXref "BTO:0000365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "proximal intestine" . [] oboInOwl:hasDbXref "BTO:0000365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002114 ; owl:annotatedTarget "upper intestine" . [] oboInOwl:order "3" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget _:genid122651 . [] oboInOwl:hasDbXref "MGI:monikat", "MP:0004002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "The portion of the small intestine that extends from the duodenum to the ileum." . _:genid121881 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000053" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "The first two fifth of the small intestine beyond the duodenum. It extends from the end of the duodenum to the ileum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001895 . [] oboInOwl:source "ncithesaurus:Jejunum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "UMLS:C0022378" . _:genid121883 oboInOwl:hasDbXref "BTO:0000657" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "intestinum jejunum" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 . [] oboInOwl:hasDbXref "Wikipedia:Jejunum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "mid-intestine" . _:genid121885 oboInOwl:hasDbXref "BTO:0000657" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002115 ; owl:annotatedTarget "middle intestine" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006215 . [] oboInOwl:order "3" ; oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget obo:UBERON_0004921 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0002581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "The portion of the small intestine that extends from the jejunum to the colon." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000647" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Ileum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "UMLS:C0020885" . [] oboInOwl:hasDbXref "BTO:0000620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "distal intestine" . [] oboInOwl:hasDbXref "BTO:0000620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "intestinum ileum" . [] oboInOwl:hasDbXref "BTO:0000620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "lower intestine" . [] oboInOwl:hasDbXref "Wikipedia:Ileum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002116 ; owl:annotatedTarget "posterior intestine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27380030" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002118 ; owl:annotatedTarget "An ovary that is part of a right side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002118 ; owl:annotatedTarget "EMAPA:37367" . [] oboInOwl:source "ncithesaurus:Right_Ovary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002118 ; owl:annotatedTarget "UMLS:C0227873" . (obo:UBERON_0000992 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000468 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002119 ; owl:annotatedTarget "An ovary that is part of a left side of organism [Automatically generated definition]." . _:genid121908 oboInOwl:source "Wikipedia:Ovary#In_other_animals" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002119 ; owl:annotatedTarget "In some elasmobranchs, the left ovary does not mature, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001891 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002119 ; owl:annotatedTarget "EMAPA:37366" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000359 ; owl:annotatedTarget "A smooth muscle cell associated with the vasculature." . [] oboInOwl:source "ncithesaurus:Left_Ovary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002119 ; owl:annotatedTarget "UMLS:C0227874" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget obo:UBERON_0002113 . [] oboInOwl:source "OG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget _:genid122686 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget _:genid122688 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget _:genid122690 . [] oboInOwl:hasDbXref "GO:0048793", "Wikipedia:Pronephros" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000037" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "A kidney formed of nephric tubules arising in the anterior region of the nephric ridge; forms only as a transient embryonic structure. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.748][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011089" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "Organ that serves as a transient kidney, providing osmoregulation during early developmental stages and then degenerating during metamorphosis.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000151" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "The embryonic kidney, present at the level of the third somite, is composed of two glomeruli fused at the midline, two pronephric tubules, and paired bilateral pronephric ducts that modify the composition of the blood filtrate before delivering it to the cloaca for excretion.Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000037" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.637", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pronephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "UMLS:C0231048" . [] oboInOwl:hasDbXref "XAO:0002000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "pronephric kidney" . [] oboInOwl:hasDbXref "BTO:0001541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "archinephron" . [] oboInOwl:hasDbXref "BTO:0001541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "embryonic kidney" . [] oboInOwl:hasDbXref "BTO:0001541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002120 ; owl:annotatedTarget "pronephron" . [] oboInOwl:hasDbXref "MP:0002368" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002122 ; owl:annotatedTarget "The fibrous connective tissue surrounding the thymus." . [] oboInOwl:source "ncithesaurus:Thymic_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002122 ; owl:annotatedTarget "UMLS:C0229945" . _:genid121939 oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002371" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002123 ; owl:annotatedTarget "The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002138 . [] oboInOwl:source "ncithesaurus:Thymus_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002123 ; owl:annotatedTarget "UMLS:C0229948" . [] oboInOwl:hasDbXref "BTO:0002934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002123 ; owl:annotatedTarget "thymic cortex" . [] oboInOwl:hasDbXref "MA:0000767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002123 ; owl:annotatedTarget "thymus cortex" . [] oboInOwl:hasDbXref "Wikipedia:Thymus#Medulla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002124 ; owl:annotatedTarget "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." . [] oboInOwl:source "ncithesaurus:Thymus_Medulla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002124 ; owl:annotatedTarget "UMLS:C0229949" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002124 ; owl:annotatedTarget "medulla of thymus gland" . _:genid121951 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002124 ; owl:annotatedTarget "thymus gland medulla" ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0036161 . (obo:UBERON_0009911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 ] ) . ( ) . [] oboInOwl:hasDbXref "Flybase:dsj", "MA:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "An epithelial cell of the integument (the outer layer of an organism)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:Thymic_Lobule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002125 ; owl:annotatedTarget "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." . [] oboInOwl:source "ncithesaurus:Thymic_Lobule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002125 ; owl:annotatedTarget "UMLS:C1522462" . [] oboInOwl:hasDbXref "FMA:72215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002125 ; owl:annotatedTarget "lobule of thymus" . [] oboInOwl:hasDbXref "MA:0000770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002125 ; owl:annotatedTarget "thymus lobule" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget _:genid122742 . _:genid121967 oboInOwl:hasDbXref "ISBN:0-19-502694-2", "Wikipedia:Superior_olivary_complex" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004684 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget obo:UBERON_0002597 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget obo:UBERON_0006840 . [] oboInOwl:hasDbXref "FMA:62411" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "cell of epidermis" . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget obo:UBERON_0007634 . [] oboInOwl:source "BIRNLEX:1307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "UMLS:C0175427" . [] oboInOwl:source "BIRNLEX:1307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "neuronames:569" . [] oboInOwl:hasDbXref "FMA:72247", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "nucleus olivaris superior" . [] oboInOwl:hasDbXref "FMA:72247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "superior olivary nuclei" . [] oboInOwl:hasDbXref "NeuroNames:569" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "regio olivaris superioris" . [] oboInOwl:hasDbXref "FMA:72247" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "superior olivary nucleus" . [] oboInOwl:hasDbXref "NeuroNames:569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "superior olivary nucleus (Barr & Kiernan)" . [] oboInOwl:hasDbXref "FMA:72247", "ISBN:0-19-502694-2" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002128 ; owl:annotatedTarget "superior olive" . [] oboInOwl:hasDbXref "FMA:62411" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0000362 ; owl:annotatedTarget "epithelial cell of skin" . _:genid121980 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0000170, obo:UBERON_0002037 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget _:genid122758 . [] oboInOwl:hasDbXref "BIRNLEX:1566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget obo:UBERON_0002130 . [] oboInOwl:source "GO:0021695" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function[GO][GO:0021695]." . [] oboInOwl:source "BIRNLEX:1566", "ncithesaurus:Cerebellar_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "UMLS:C0007759" . [] oboInOwl:source "BIRNLEX:1566" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "UMLS:C1284087" . [] oboInOwl:source "BIRNLEX:1566" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "neuronames:647" . [] oboInOwl:hasDbXref "DMBA:CbHCx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "cortex of cerebellar hemisphere" . [] oboInOwl:hasDbXref "BTO:0000043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "cortex cerebellaris" . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000365 ; owl:annotatedTarget "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." . [] oboInOwl:hasDbXref "NeuroNames:647" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002129 ; owl:annotatedTarget "cortex cerebelli" . [] oboInOwl:hasDbXref "MP:0009979", "Wikipedia:Deep_cerebellar_nuclei" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP]." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget obo:UBERON_0002129 . [] oboInOwl:source "BIRNLEX:1568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "UMLS:C0007763" . [] oboInOwl:source "BIRNLEX:1568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "neuronames:682" . [] oboInOwl:hasDbXref "BIRNLEX:1568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "deep cerebellar nuclear complex" . [] oboInOwl:hasDbXref "FMA:72249", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "nuclei cerebelli" . [] oboInOwl:hasDbXref "NeuroNames:682" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "nuclei cerebellares" . [] oboInOwl:hasDbXref "NeuroNames:682" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "nuclei cerebellaris" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27412799" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000393 ; owl:annotatedTarget "A cell whose function is determined by its response to an electric signal." . [] oboInOwl:hasDbXref "Wikipedia:Deep_cerebellar_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002130 ; owl:annotatedTarget "nuclei cerebelli" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0009980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "The largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget obo:UBERON_0002153 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001700" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471210054 Butler AB, Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.260-261", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "One or more deep cerebellar nuclei appear in agnathans, sharks, ropefishes, lungfishes, Latimeria, and amphibians. Reptiles have two nuclei (a medial and a lateral), and birds and mammals have three nuclei (a medial, a lateral, and an interposed nucleus). The medial nucleus of mammals is known as the fastigial nucleus, and the lateral nucleus is known as the dentate nucleus.[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1171" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "UMLS:C0086120" . [] oboInOwl:source "BIRNLEX:1171" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "neuronames:683" . [] oboInOwl:hasDbXref "BIRNLEX:1171" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "dentate cerebellar nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Dentate_nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "dentate nucleus" . [] oboInOwl:hasDbXref "NeuroNames:683" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "dentate nucleus (Vicq d'Azyr)" . [] oboInOwl:hasDbXref "Wikipedia:Dentate_nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "dentatothalamocortical fibers" . [] oboInOwl:hasDbXref "Wikipedia:Dentate_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "nucleus dentatus" . [] oboInOwl:hasDbXref "NeuroNames:683" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "nucleus dentatus cerebelli" . [] oboInOwl:hasDbXref "NeuroNames:683" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002132 ; owl:annotatedTarget "nucleus lateralis cerebelli" . _:genid122017 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget _:genid122793 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002145 . [] oboInOwl:source "PMID:15797462", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget _:genid122798 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget _:genid122800 . [] oboInOwl:hasDbXref "Wikipedia:Heart_valve#Atrioventricular_valves", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "A cardial valve in the atrioventricular region that separates the atrium from the ventricle and prevent backflow from the ventricles into the atria during systole." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005064" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "The atrioventricular valve has four distinct leaflets oriented anterior, posterior, left, and right of the atrioventricular orifice. Hu et al. 2001.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001472" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/atrioventricular+valve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "Valve in the heart through which blood flows from the atria to the ventricles. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001472" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1152/physrev.00006.2003", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "The conus arteriosus is the most distal part of the primitive fish heart and forms the connection between the ventricle and the ventral aorta. At the sinoatrial, the atrioventricular, and the ventriculoconal junctions, valves developed to prevent backflow of blood during relaxation of the preceding compartment.[uncertain][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "in ZFA this is part of both atrium and ventricle, but we use a connecting relationship here; see also notes for left and right." . [] oboInOwl:hasDbXref "EMAPA:35154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002133 ; owl:annotatedTarget "atrio-ventricular valve" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "An atrioventricular valve that is part of the outflow part of the right atrium." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000816" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Tricuspid+valves" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "The three-segmented valve of the heart that keeps blood in the right ventricle from flowing back into the right atrium. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000816" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "FMA part_ofs changed to connects" . [] oboInOwl:source "ncithesaurus:Tricuspid_Valve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "UMLS:C0040960" . [] oboInOwl:hasDbXref "FMA:7234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "right atrioventricular valve" . [] oboInOwl:hasDbXref "FMA:7234", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "valva atrioventricularis dextra" . [] oboInOwl:hasDbXref "Wikipedia:Tricuspid_valve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002134 ; owl:annotatedTarget "valvula tricuspidalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget _:genid122826 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget _:genid122828 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget _:genid122830 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "An atrioventricular valve that is part of the outflow part of the left atrium." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000817" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mitral+valve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "A valve of the heart, composed of two triangular flaps, that is located between the left atrium and left ventricle and regulates blood flow between these chambers. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000817" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000397 ; owl:annotatedTarget obo:CL_0000099 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "FMA part_ofs changed to connects" . [] oboInOwl:source "ncithesaurus:Mitral_Valve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "UMLS:C0026264" . [] oboInOwl:hasDbXref "FMA:7235", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "valva atrioventricularis sinistra" . [] oboInOwl:hasDbXref "Wikipedia:Mitral_valve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002135 ; owl:annotatedTarget "valva mitralis" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002137 ; owl:annotatedTarget obo:UBERON_0005623 . _:genid122056 oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Aortic_valve" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002137 ; owl:annotatedTarget "Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000815" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/aortic+valve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002137 ; owl:annotatedTarget "The valve between the left ventricle of the heart and the ascending aorta, consisting of three semilunar cusps. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Aortic_Valve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002137 ; owl:annotatedTarget "UMLS:C0003501" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_valve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002137 ; owl:annotatedTarget "valva aortae" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_valve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002146 ; owl:annotatedTarget "The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery." . _:genid122067 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000814" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pulmonary+valve" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002146 ; owl:annotatedTarget "The valve with semilunar cusps at the entrance to the pulmonary trunk from the right ventricle of the heart. [TFD][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000011 . [] oboInOwl:source "ncithesaurus:Pulmonary_Valve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002146 ; owl:annotatedTarget "UMLS:C0034086" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_valve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002146 ; owl:annotatedTarget "valva trunci pulmonalis" . [] oboInOwl:notes "check ZFA" ; oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget _:genid122855 . [] oboInOwl:hasDbXref "GAID:577", "GO:0021703", "Wikipedia:Locus_ceruleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget obo:UBERON_0002047 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget obo:UBERON_0002267 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget obo:UBERON_0002587 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget obo:UBERON_0003004 . [] oboInOwl:source "BIRNLEX:905", "ncithesaurus:Locus_Coeruleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "UMLS:C0023951" . _:genid122078 oboInOwl:source "BIRNLEX:905" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "neuronames:583" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001308 . [] oboInOwl:hasDbXref "Noradrenergic_cell_group_A6&oldid=981960774" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "Noradrenergic cell group A6" . [] oboInOwl:hasDbXref "BIRNLEX:905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "blue nucleus" . [] oboInOwl:hasDbXref "BIRNLEX:905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "locus caeruleus" . [] oboInOwl:hasDbXref "FMA:72478", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "nucleus caeruleus" . [] oboInOwl:hasDbXref "BIRNLEX:905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "nucleus pigmentosus pontis" . [] oboInOwl:hasDbXref "BIRNLEX:905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "substantia ferruginea" . [] oboInOwl:hasDbXref "ZFA:0000539" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "loci coeruleus" . _:genid122086 oboInOwl:hasDbXref "BTO:0001408" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "locus cinereus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 . [] oboInOwl:hasDbXref "NeuroNames:583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "locus coeruleus (Vicq d'Azyr)" . _:genid122088 oboInOwl:hasDbXref "NeuroNames:583" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002148 ; owl:annotatedTarget "nucleus loci caerulei" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005498 . _:genid122090 oboInOwl:source "NIFSTD" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget _:genid122875 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005432 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget _:genid122878 . [] oboInOwl:hasDbXref "BIRNLEX:1131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002143 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002147 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002151 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002633 . _:genid122097 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002682 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002963 . _:genid122099 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0002968 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002165 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27471162" . [] oboInOwl:hasDbXref "doi:10.1016/B978-0-12-817424-1.00001-X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000402 ; owl:annotatedTarget "An interneuron that has its cell body in a central nervous system." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0003011 . _:genid122101 oboInOwl:source "ABA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget obo:UBERON_0007632 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "EMAPA:37756" . [] oboInOwl:source "BIRNLEX:1131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "UMLS:C0175447" . [] oboInOwl:source "BIRNLEX:1131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "neuronames:590" . [] oboInOwl:hasDbXref "GO:0021753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "superior salivary nucleus" . [] oboInOwl:hasDbXref "NeuroNames:590" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "nucleus salivarius superior" . [] oboInOwl:hasDbXref "NeuroNames:590" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "nucleus salivatorius cranialis" . [] oboInOwl:hasDbXref "NeuroNames:590" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "nucleus salivatorius rostralis" . [] oboInOwl:hasDbXref "NeuroNames:590" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002149 ; owl:annotatedTarget "nucleus salivatorius superior" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000404 ; owl:annotatedTarget "A cell that initiates an electrical signal and passes that signal to another cell." . [] oboInOwl:hasDbXref "BIRNLEX:1711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)." . [] oboInOwl:external_ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "we make the TAO class disjoint for now as it's not clear if this is the analagous structure" . _:genid122112 oboInOwl:source "BIRNLEX:1711" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "UMLS:C0152391" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002350 . [] oboInOwl:source "BIRNLEX:1711" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "neuronames:1736" . _:genid122114 oboInOwl:hasDbXref "BIRNLEX:1711" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "brachium conjunctivum" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007278 . [] oboInOwl:hasDbXref "NeuroNames:1736" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "crus cerebello-cerebrale" . [] oboInOwl:hasDbXref "NeuroNames:1736" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "pedunculus cerebellaris cranialis" . [] oboInOwl:hasDbXref "NeuroNames:1736" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "pedunculus cerebellaris rostralis" . [] oboInOwl:hasDbXref "Wikipedia:Superior_cerebellar_peduncle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "pedunculus cerebellaris superior" . [] oboInOwl:hasDbXref "MBA:326" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "scp" . [] oboInOwl:hasDbXref "MBA:326" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "superior cerebelar peduncles" . [] oboInOwl:hasDbXref "NeuroNames:1736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "superior cerebellar peduncle (Galen, Stilling)" . [] oboInOwl:hasDbXref "BAMS:scp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "superior cerebellar peduncle (brachium conjuctivum)" . [] oboInOwl:hasDbXref "BAMS:scp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "superior cerebellar peduncle (brachium conjunctivum)" . [] oboInOwl:hasDbXref "Wikipedia:Superior_cerebellar_peduncle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "superior peduncle" . [] oboInOwl:hasDbXref "NeuroNames:1736" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "tractus cerebello-rubralis" . [] oboInOwl:hasDbXref "NeuroNames:1736" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002150 ; owl:annotatedTarget "tractus cerebello-tegmentalis mesencephali" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget _:genid122916 . [] oboInOwl:hasDbXref "BIRNLEX:1529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM)." . [] oboInOwl:source "BIRNLEX:1529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "UMLS:C0152392" . [] oboInOwl:source "BIRNLEX:1529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "neuronames:620" . [] oboInOwl:hasDbXref "BIRNLEX:1529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "brachium pontis" . [] oboInOwl:hasDbXref "BAMS:bp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "brachium pontis (stem of middle cerebellar peduncle)" . [] oboInOwl:hasDbXref "NeuroNames:620" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "crus cerebelli ad pontem" . [] oboInOwl:hasDbXref "NeuroNames:620" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "crus ponto-cerebellare" . [] oboInOwl:hasDbXref "NeuroNames:620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "mid-cerebellar peduncle" . [] oboInOwl:hasDbXref "NeuroNames:620" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "pedunculus cerebellaris medialis" . [] oboInOwl:hasDbXref "Wikipedia:Middle_cerebellar_peduncle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "pedunculus cerebellaris medius" . [] oboInOwl:hasDbXref "NeuroNames:620" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002152 ; owl:annotatedTarget "pedunculus cerebellaris pontinus" . _:genid122142 oboInOwl:source "Bgee:AN" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget _:genid122931 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002097 . [] oboInOwl:hasDbXref "GO:0003157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001320" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "Layer that lines the lumen of the heart.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010408" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO]" . [] oboInOwl:source "FMA:7280" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber." . [] oboInOwl:source "ncithesaurus:Endocardium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "UMLS:C0014124" . _:genid122148 oboInOwl:hasDbXref "EMAPA:32686" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "endocardial lining" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:hasDbXref "EMAPA:17868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "endocardial tissue" . [] oboInOwl:hasDbXref "VHOG:0000084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002165 ; owl:annotatedTarget "heart endocardial tissue" . _:genid122151 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010083 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "Endocardium that is part of the atrium." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "Cardiac atria endocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "atrium of heart endocardium" . _:genid122160 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "cardiac atrium endocardium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "endocardium of Cardiac atria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "endocardium of atrium of heart" . _:genid122163 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "endocardium of cardiac atrium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004340 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "endocardium of heart atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "heart atrium endocardium" . [] oboInOwl:hasDbXref "VHOG:0000606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002166 ; owl:annotatedTarget "atrium endocardial tissue" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Right_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002167 ; owl:annotatedTarget "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000301" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002167 ; owl:annotatedTarget "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Right_Lung" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002167 ; owl:annotatedTarget "UMLS:C0225706" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Left_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002168 ; owl:annotatedTarget "Lung which consists of the left upper lobe and left lower lobe.[FMA]." . _:genid122179 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000618" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002168 ; owl:annotatedTarget "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget obo:CL_0000015 . [] oboInOwl:source "ncithesaurus:Left_Lung" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002168 ; owl:annotatedTarget "UMLS:C0225730" . _:genid122185 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002299, obo:UBERON_0011825 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget _:genid122975 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget _:genid122977 . [] oboInOwl:hasDbXref "MP:0010902", "Wikipedia:Alveolar_sac" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000408 ; owl:annotatedTarget obo:CL_0000300 . [] oboInOwl:source "ncithesaurus:Alveolar_Sac" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget "UMLS:C0225691" . [] oboInOwl:hasDbXref "MP:0010902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget "pulmonary alveolar sac" . [] oboInOwl:hasDbXref "FMA:7317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget "sacculus alveolaris" . [] oboInOwl:hasDbXref "MP:0010902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002169 ; owl:annotatedTarget "air sac" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget _:genid122986 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget obo:UBERON_0002258 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ventral+funiculus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "The white substance of the spinal cord lying on either side between the ventral median fissure and the ventral roots of the spinal nerves." . [] oboInOwl:hasDbXref "FMA:74003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "anterior white column of spinal cord" . _:genid122198 oboInOwl:hasDbXref "FMA:74003", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "funiculus anterior medullae spinalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001003 . [] oboInOwl:hasDbXref "ZFA:0000605" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "ventral funiculus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:27535560" . [] oboInOwl:hasDbXref "FB:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000412 ; owl:annotatedTarget "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." . _:genid122200 oboInOwl:hasDbXref "FMA:74003" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "ventral white column of spinal cord" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011932 . [] oboInOwl:hasDbXref "ZFA:0000605" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002180 ; owl:annotatedTarget "ventral funiculi" . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MESH:A04.411.125", "MGI:cwg", "MP:0002264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget obo:NCBITaxon_8507 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000262" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:source "ncithesaurus:Bronchus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "UMLS:C0006255" . _:genid122208 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "bronchi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001037 . [] oboInOwl:hasDbXref "FMA:7409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "bronchial trunk" . [] oboInOwl:hasDbXref "BTO:0001340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002185 ; owl:annotatedTarget "bronchial tissue" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget _:genid123004 . [] oboInOwl:source "ncit" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget _:genid123006 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget _:genid123008 . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching." . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "In FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however, there are two distinct terms for the corresponding epithelium." . [] oboInOwl:source "ncithesaurus:Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "UMLS:C0006270" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "bronchioli" . [] oboInOwl:hasDbXref "BTO:0002375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "bronchiolus" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/2795" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:UBERON_0002186 ; owl:annotatedTarget "In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole." . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002268" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002187 ; owl:annotatedTarget "The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls." . [] oboInOwl:source "ncithesaurus:Terminal_Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002187 ; owl:annotatedTarget "UMLS:C0225666" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002187 ; owl:annotatedTarget "bronchiolus terminalis" . [] oboInOwl:hasDbXref "Wikipedia:Terminal_bronchiole" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002187 ; owl:annotatedTarget "bronchioli terminalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." . [] oboInOwl:source "MP:0011156" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156]" . [] oboInOwl:hasDbXref "MP:0011156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "panniculus adiposus" . [] oboInOwl:hasDbXref "FMA:74315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "fatty layer of subcutaneous tissue" . [] oboInOwl:hasDbXref "MP:0011156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "hypodermis fat layer" . [] oboInOwl:hasDbXref "FMA:74315", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "panniculus adiposus (tela subcutanea)" . [] oboInOwl:hasDbXref "FMA:74315", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "panniculus adiposus telae subcutaneae" . [] oboInOwl:hasDbXref "MP:0011156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "subcutaneous fat layer" . [] oboInOwl:hasDbXref "FMA:74315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "fatty layer of superficial fascia" . [] oboInOwl:hasDbXref "BTO:0004042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002190 ; owl:annotatedTarget "subcutaneous fat" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002193 ; owl:annotatedTarget obo:UBERON_0000467 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002193 ; owl:annotatedTarget "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." . [] oboInOwl:hasDbXref "Wikipedia:Lymph_node#Capsule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002194 ; owl:annotatedTarget "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers." . [] oboInOwl:source "ncithesaurus:Lymph_Node_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002194 ; owl:annotatedTarget "UMLS:C0229699" . [] oboInOwl:hasDbXref "FMA:74604", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002194 ; owl:annotatedTarget "capsula nodi lymphoidei" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000413 ; owl:annotatedTarget "A cell whose nucleus contains a single haploid genome." . [] oboInOwl:hasDbXref "Wikipedia:Lymph_node_trabeculae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002195 ; owl:annotatedTarget "Membranous process coming from capsule of lymph node[WP]." . [] oboInOwl:source "ncithesaurus:Lymph_Node_Trabecula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002195 ; owl:annotatedTarget "UMLS:C1184179" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002195 ; owl:annotatedTarget "lymph node trabeculae" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002195 ; owl:annotatedTarget "trabeculae of lymph node" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Reticular_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000432 ; owl:annotatedTarget "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget _:genid123055 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget _:genid123058 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget _:genid123060 . [] oboInOwl:source "NCBIBook:NBK53175", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget _:genid123063 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget obo:UBERON_0002198 . [] oboInOwl:hasDbXref "Wikipedia:Adenohypophysis", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010540" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "Region of the pituitary gland derived from the buccal protrusion consisting of three regions.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001282" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin. In contrast to mamalian vertebrates, the adenohypophysis remains in a subepithelial position and there exists no equivalent of Rathke's pouch in zebrafish. Herzog et al, 2004.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000141" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "In contrast to mammalian vertebrates, the adenohypophysis remains in a subepithelial position and there exists no equivalent of Rathke's pouch in zebrafish" . _:genid122272 oboInOwl:hasDbXref "BIRNLEX:1581", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "AHP" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009889 . [] oboInOwl:source "BIRNLEX:1581", "ncithesaurus:Anterior_Lobe_of_the_Pituitary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "UMLS:C0032008" . _:genid122274 oboInOwl:source "BIRNLEX:1581" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "UMLS:C1280369" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0004706 . [] oboInOwl:source "BIRNLEX:1581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "neuronames:407" . [] oboInOwl:hasDbXref "ZFA:0001282" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "anterior hypophysis" . [] oboInOwl:hasDbXref "FMA:74627", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "lobus anterior (glandula pituitaria)" . [] oboInOwl:hasDbXref "FMA:74627", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "lobus anterior hypophysis" . [] oboInOwl:hasDbXref "BAMS:APit" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "anterior lobe of the pituitary" . [] oboInOwl:hasDbXref "BTO:0000040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "anterior pituitary gland" . [] oboInOwl:hasDbXref "BTO:0000496" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "cranial lobe" . [] oboInOwl:hasDbXref "NeuroNames:407" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "lobus anterior" . [] oboInOwl:hasDbXref "EMAPA:17514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "pituitary anterior lobe" . [] oboInOwl:hasDbXref "BAMS:AL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "pituitary glandanterior lobe" . [] oboInOwl:hasDbXref "BTO:0000496" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002196 ; owl:annotatedTarget "rostral lobe" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget obo:UBERON_0010134 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget _:genid123087 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget _:genid123090 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget _:genid123092 . [] oboInOwl:hasDbXref "MP:0004164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon." . [] oboInOwl:source "http://syllabus.med.unc.edu/courseware/embryo_images/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "request magnocellular cell from CL. Request oxytocin secretion from GO. Notes: 'The hypophysis or pituitary gland is derived, in part from an ectodermal outpocketing of the stomodeum (Rathke's Pouch) and in part from the floor of the diencephalon'" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010537" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "The infundibular part of the pituitary gland consisting of two regions.[AAO]" . _:genid122294 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000142" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006283 . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "todo - resolve EMAPA and EHDAA2 models, include future neurohypophysis (TS15-19)? relationship to infundibular recess of 3rd ventricle (TS15-19)" . [] oboInOwl:hasDbXref "BIRNLEX:1586", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "NHP" . [] oboInOwl:source "BIRNLEX:1586", "ncithesaurus:Posterior_Lobe_of_the_Pituitary_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "UMLS:C0032009" . [] oboInOwl:source "BIRNLEX:1586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "UMLS:C1280368" . [] oboInOwl:source "BIRNLEX:1586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "neuronames:401" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:3106924" . [] oboInOwl:hasDbXref "FMA:74628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "infundibular process" . [] oboInOwl:hasDbXref "FMA:74628", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "lobus nervosus neurohypophysis" . [] oboInOwl:hasDbXref "FMA:74628", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "lobus posterior (glandula pituitaria)" . [] oboInOwl:hasDbXref "FMA:74628", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "lobus posterior hypophysis" . [] oboInOwl:hasDbXref "FMA:74628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "neural lobe" . [] oboInOwl:hasDbXref "BIRNLEX:1586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "neural lobe of pituitary" . [] oboInOwl:hasDbXref "FMA:74628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "neural lobe of pituitary gland" . _:genid122307 oboInOwl:hasDbXref "FMA:74628" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "posterior lobe of pituitary gland" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004140 . [] oboInOwl:hasDbXref "NeuroNames:401" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "lobus nervosus" . [] oboInOwl:hasDbXref "NeuroNames:401" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "lobus posterior" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000438 ; owl:annotatedTarget "A peptide hormone secreting cell pituitary that produces luteinizing hormone." . [] oboInOwl:hasDbXref "BAMS:NL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "pituitary gland neural lobe" . [] oboInOwl:hasDbXref "NeuroNames:401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "pituitary gland, neural lobe" . [] oboInOwl:hasDbXref "NeuroNames:401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "posterior lobe of hypophysis" . [] oboInOwl:hasDbXref "BTO:0000937" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002198 ; owl:annotatedTarget "posterior pituitary gland" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget _:genid123118 . [] oboInOwl:hasDbXref "Wikipedia:Integument" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "The dermis, epidermis and hypodermis." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000239" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000029" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "Surface structure that is the outer protective covering of the body.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000368" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "EMAPA:37504" . [] oboInOwl:hasDbXref "FMA:74657", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "integumentum commune" . _:genid122325 oboInOwl:hasDbXref "FMA:74657" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "the integument" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011820 . [] oboInOwl:hasDbXref "BTO:0000634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "dermal system" . [] oboInOwl:hasDbXref "BTO:0000634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "dermoid system" . [] oboInOwl:hasDbXref "BTO:0000634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002199 ; owl:annotatedTarget "tegument" . _:genid122329 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 ] ) ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007279 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "Vasculature that is part of a head [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "adult head vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "adult head vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "head vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "vascular network of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "vascular network of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002200 ; owl:annotatedTarget "vasculature of adult head" . _:genid122344 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "A vasculature that is part of a trunk [Automatically generated definition]." ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0000985 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "torso vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "torso vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "trunk vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "vascular network of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "vascular network of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002201 ; owl:annotatedTarget "vasculature of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002202 ; owl:annotatedTarget "A submucosa that is part of a trachea." . [] oboInOwl:source "ncithesaurus:Trachea_Submucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002202 ; owl:annotatedTarget "UMLS:C0225586" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002202 ; owl:annotatedTarget "submucosa of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002202 ; owl:annotatedTarget "windpipe submucosa" . [] oboInOwl:hasDbXref "BTO:0002115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002202 ; owl:annotatedTarget "submucous layer of trachea" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000439 ; owl:annotatedTarget "A peptide hormone cell that secretes prolactin." . [] oboInOwl:source "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget _:genid123168 . [] oboInOwl:hasDbXref "OBOL:automatic", "https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget "Vasculature that is part of the eye region." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget "not part of the eye in ZFA. Note this changed to a blood vessel in ZFA" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget "eye vascular network" . [] oboInOwl:hasDbXref "ZFA:0007057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget "ocular blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002203 ; owl:annotatedTarget "vascular network of eye" . [] oboInOwl:notes "check ctenophore" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002204 ; owl:annotatedTarget _:genid123178 . [] oboInOwl:hasDbXref "VSAO:0000031", "VSAO:curator", "https://github.com/obophenotype/uberon/issues/77" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002204 ; owl:annotatedTarget "Anatomical system that consists of the muscular and skeletal systems." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010546" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002204 ; owl:annotatedTarget "Anatomical system that provides locomotion and physical support to the organism.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001275" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jez.b.21246 Shearman RM, Burke AC, The lateral somitic frontier in ontogeny and phylogeny. Journal of Experimental Zoology (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002204 ; owl:annotatedTarget "There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Musculoskeletal_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002204 ; owl:annotatedTarget "UMLS:C0026860" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget _:genid123186 . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process", "https://sourceforge.net/tracker/?func=detail&aid=3153001&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "A cartilaginous extension to the distal part of the sternum." . [] oboInOwl:source "WP,unvetted" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "this class may represent a mixed bony-cartilage element, or it may be the superclass of either purely cartilage or purely ossified elements" . [] oboInOwl:source "ncithesaurus:Xiphoid_Process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "UMLS:C0043356" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphisternum" . [] oboInOwl:hasDbXref "FMA:7488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphoid process" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "metasternum" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "processus xiphoideus" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphoid" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphoid process" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphoideus" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xiphosternal junction" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002207 ; owl:annotatedTarget "xyphoid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002208 ; owl:annotatedTarget _:genid123200 . [] oboInOwl:hasDbXref "Wikipedia:Sternebra", "http://medical-dictionary.thefreedictionary.com/sternebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002208 ; owl:annotatedTarget "One of the bony segments of the sternum[TFD]." . [] oboInOwl:hasDbXref "EMAPA:18724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002208 ; owl:annotatedTarget "sternebral bone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002209 ; owl:annotatedTarget obo:UBERON_0011134 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002209 ; owl:annotatedTarget _:genid123206 . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Fibrous_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002209 ; owl:annotatedTarget "Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA]." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:3393260" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005156" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002209 ; owl:annotatedTarget "A joint where fibrous tissue such as ligament connects two calcified tissues.[TAO]" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002209 ; owl:annotatedTarget "junctura fibrosa" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Syndesmosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002210 ; owl:annotatedTarget "Fibrous joint in which the articulating bones or cartilages of the vertebral column and the limbs as well as articulating ossicles, are connected by skeletal ligaments or membranes. Examples: Intervertebral syndesmosis, inferior tibiofibular joint.[FMA]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002210 ; owl:annotatedTarget "EMAPA:37465" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002213 ; owl:annotatedTarget obo:UBERON_0011134 . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Cartilaginous_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002213 ; owl:annotatedTarget "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000440 ; owl:annotatedTarget "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." . [] oboInOwl:hasDbXref "Wikipedia:Cartilaginous_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002213 ; owl:annotatedTarget "junctura cartilaginea" . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Synchondrosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002215 ; owl:annotatedTarget "Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA]." . _:genid122416 oboInOwl:hasDbXref "FMA:7497", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002215 ; owl:annotatedTarget "cartilago epiphysialis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011272 . [] oboInOwl:hasDbXref "FMA:7497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002215 ; owl:annotatedTarget "primary cartilaginous joint" . [] oboInOwl:hasDbXref "FMA:7497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002215 ; owl:annotatedTarget "epiphysial cartilage" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002216 ; owl:annotatedTarget obo:UBERON_0002209 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002216 ; owl:annotatedTarget obo:UBERON_0002213 . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Symphysis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002216 ; owl:annotatedTarget "Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002216 ; owl:annotatedTarget "EMAPA:37758" . [] oboInOwl:hasDbXref "FMA:7498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002216 ; owl:annotatedTarget "secondary cartilaginous joint" . [] oboInOwl:hasDbXref "FMA:7501", "Wikipedia:Synovial_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002217 ; owl:annotatedTarget "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005153" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002217 ; owl:annotatedTarget "Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0005153" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002217 ; owl:annotatedTarget "diarthroses" . [] oboInOwl:hasDbXref "ZFA:0005153" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002217 ; owl:annotatedTarget "diarthrodial joints" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget obo:UBERON_0002209 . [] oboInOwl:source "MA", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget _:genid123242 . [] oboInOwl:hasDbXref "Wikipedia:Fontanelle", "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001738" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "Anatomical structure that is a membranous gap between bones of the skull.[TAO]" . [] oboInOwl:source "ncithesaurus:Fontanelle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "UMLS:C0224548" . [] oboInOwl:hasDbXref "TAO:0001738" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "fontanelles" . [] oboInOwl:hasDbXref "TAO:0001738" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "fontanels" . [] oboInOwl:hasDbXref "Wikipedia:Fontanelle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002221 ; owl:annotatedTarget "fonticuli cranii" . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Thoracic_cavity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002224 ; owl:annotatedTarget "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." . [] oboInOwl:source "ncithesaurus:Thoracic_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002224 ; owl:annotatedTarget "UMLS:C0230139" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002224 ; owl:annotatedTarget "cavitas thoracis" . [] oboInOwl:hasDbXref "FMA:7565" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002224 ; owl:annotatedTarget "space of thoracic compartment" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget _:genid123265 . [] oboInOwl:hasDbXref "Wikipedia:Rib", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget "An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000538" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget "Endochondral bone that is intersegmental and rod-shaped, forming in the peritoneal membrane and attached to the vertebral parapophyses. Ribs protect and support internal organs.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000545" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_2002" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget "Endochondral, rodlike element that articulates with the transverse process and parapophysis (double-headed rib), or with the transverse process only (single-headed rib); it extends into the body wall and provides a site for muscle attachment.[AAO]" . [] oboInOwl:source "ncithesaurus:Rib" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget "UMLS:C0035561" . [] oboInOwl:hasDbXref "FMA:69078", "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000446 ; owl:annotatedTarget "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." . [] oboInOwl:hasDbXref "TAO:0000538" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002228 ; owl:annotatedTarget "ribs" . [] oboInOwl:source "PMID:15906248" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002231 ; owl:annotatedTarget _:genid123272 . [] oboInOwl:source "ncithesaurus:Rib_Shaft" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002231 ; owl:annotatedTarget "UMLS:C0448161" . [] oboInOwl:hasDbXref "FMA:7577", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002231 ; owl:annotatedTarget "corpus costae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "A proximal phalanx that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "EMAPA:37307" . [] oboInOwl:source "ncithesaurus:Proximal_Phalanx_of_Hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "UMLS:C0730117" . [] oboInOwl:hasDbXref "MA:0001395" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "hand proximal phalanx" . [] oboInOwl:hasDbXref "FMA:75816", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "phalanx proximalis manus" . [] oboInOwl:hasDbXref "FMA:75816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002234 ; owl:annotatedTarget "proximal phalanx of finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget _:genid123292 . [] oboInOwl:source "PMID:15906248" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget _:genid123294 . [] oboInOwl:hasDbXref "Wikipedia:Tubercle_(rib)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget "The tubercle of a rib is an eminence on the posterior surface, at the junction of the neck and body of the rib, and nearer the lower than the upper border. It consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs[WP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget "EMAPA:37736" . [] oboInOwl:source "ncithesaurus:Rib_Tubercle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget "UMLS:C0222809" . [] oboInOwl:hasDbXref "FMA:7583", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002235 ; owl:annotatedTarget "tuberculum costae" . [] oboInOwl:hasDbXref "ISBN:0-8036-0655-9", "MGI:smb", "MP:0006432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002236 ; owl:annotatedTarget "The nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it." . [] oboInOwl:source "ncithesaurus:Costal_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002236 ; owl:annotatedTarget "UMLS:C0222787" . [] oboInOwl:hasDbXref "Wikipedia:Costal_cartilage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002236 ; owl:annotatedTarget "cartilagines costales" . [] oboInOwl:hasDbXref "BTO:0001721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002236 ; owl:annotatedTarget "cartilago costalis" . [] oboInOwl:hasDbXref "BTO:0001721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002236 ; owl:annotatedTarget "sternal cartilage" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:True_ribs" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002237 ; owl:annotatedTarget "A rib that is ventrally connected to the sternum." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002237 ; owl:annotatedTarget "EMAPA:37774" . [] oboInOwl:hasDbXref "Wikipedia:True_ribs" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002237 ; owl:annotatedTarget "costae verae" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:False_rib" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002238 ; owl:annotatedTarget "A rib that is not directly ventrally connected to the sternum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:6198473" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002238 ; owl:annotatedTarget "EMAPA:37493" . [] oboInOwl:hasDbXref "Wikipedia:False_ribs" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002238 ; owl:annotatedTarget "asternal ribs" . [] oboInOwl:hasDbXref "Wikipedia:False_ribs" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002238 ; owl:annotatedTarget "costae spuriae" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Floating_rib" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "A rib that is not connected to sternum or sternal cartilage." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "EMAPA:37494" . _:genid122505 oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "costa fluitante" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002390 . [] oboInOwl:hasDbXref "PHENOSCAPE:Alex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "free rib" . [] oboInOwl:hasDbXref "Wikipedia:Floating_rib" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "costae fluctuantes" . [] oboInOwl:hasDbXref "Wikipedia:Floating_rib" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002239 ; owl:annotatedTarget "costae fluitantes" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget _:genid123325 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget _:genid123328 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget _:genid123330 . [] oboInOwl:hasDbXref "BIRNLEX:1709" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." . [] oboInOwl:exceptions "ZFA" ; oboInOwl:source "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget obo:UBERON_0000955 . _:genid122517 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010151" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000601" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" . _:genid122519 oboInOwl:source "BIRNLEX:1709", "ncithesaurus:Spinal_Cord" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "UMLS:C0037925" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 . [] oboInOwl:source "BIRNLEX:1709" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "neuronames:22" . _:genid122521 oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "SpC" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 . [] oboInOwl:hasDbXref "NeuroNames:22" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "cerebro-cerebellar fissure" . _:genid122523 oboInOwl:hasDbXref "NeuroNames:22" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "cerebrocerebellar fissure" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002330 . [] oboInOwl:hasDbXref "NeuroNames:22" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "fissura cerebro-cerebellaris" . _:genid122525 oboInOwl:hasDbXref "NeuroNames:22" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "fissura cerebrocerebellaris" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002423 . [] oboInOwl:hasDbXref "BTO:0001279", "Wikipedia:Spinal_cord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "medulla spinalis" . [] oboInOwl:hasDbXref "ZFA:0000075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "spinal cord structure" . _:genid122528 oboInOwl:hasDbXref "BTO:0001279" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002240 ; owl:annotatedTarget "spinal medulla" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002405 . _:genid122530 oboInOwl:hasDbXref "Wikipedia:Chondrocranium", "http://medical-dictionary.thefreedictionary.com/chondrocranium" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002241 ; owl:annotatedTarget "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003894 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010169" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002241 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[AAO]" . _:genid122532 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001424" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002241 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[TAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004161 . [] oboInOwl:hasDbXref "MA:0000317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002241 ; owl:annotatedTarget "calvarium" . _:genid122534 oboInOwl:hasDbXref "MA:0000317" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002241 ; owl:annotatedTarget "neurocranium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008836 . [] oboInOwl:editor "mah" ; oboInOwl:source "ISBN:0073040584", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget _:genid123357 . [] oboInOwl:hasDbXref "MGI:llw2", "MP:0006392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "we group two FMA classes together" . [] oboInOwl:hasDbXref "FMA:13550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "nucleus pulposus (diskus intervertebralis)" . [] oboInOwl:hasDbXref "Wikipedia:Nucleus_pulposus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "nucleus propulsus" . [] oboInOwl:hasDbXref "Wikipedia:Nucleus_pulposus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "nucleus propulsus of intervertebral disk" . [] oboInOwl:hasDbXref "FMA:13550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002242 ; owl:annotatedTarget "nucleus pulposus of intervertebral disk" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget _:genid123366 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget _:genid123368 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget _:genid123371 . [] oboInOwl:hasDbXref "VHOG:0000426", "Wikipedia:Incisive_bone", "Wikipedia:Premaxilla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "One of the bones of the upper jaw situated between and in front of the maxillae[VHOG]." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget obo:NCBITaxon_7901 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000567" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "Dermal bone that forms the anteriormost element of the upper jaw. It articulates with the maxilla posterodorsally and its antimere medially. The premaxilla is paired.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000426" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "One of the bones of the upper jaw situated between and in front of the maxillae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000461" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "Paired, intramembranous bones located at the anterior end of the skull; they form the anterior-most segment of the maxillary arch.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000567" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "relationship loss: overlaps inter-premaxillary joint (TAO:0001950)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000567" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "relationship loss: overlaps mesethmoid-premaxillary joint (TAO:0001676)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000567" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "relationship loss: overlaps premaxillary-maxillary joint (TAO:0002260)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000426" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100025585 O'Malley JF, Evolution of the nasal cavities and sinuses in relation to function. The Journal of Laryngology and Otology (1924), ISBN:978-3540428541 Kapoor BG, Bhavna Khanna, Ichthyology Handbook (2004) p.105", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "(...) in all higher vertebrates a premaxilla is present (...) (reference 1); Although the presence of a tooth-bearing outer buccal arcade (premaxilla, maxilla, dentary) is cited as a common character of Osteichthyes, dipnoans lack all three bones (...) (reference 2).[well established][VHOG]" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "premaxillae" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "premaxillary" . [] oboInOwl:hasDbXref "Wikipedia:Incisive_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "incisive bone" . [] oboInOwl:hasDbXref "Wikipedia:Premaxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "os incisivum" . [] oboInOwl:hasDbXref "Wikipedia:Premaxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "premaxilla bone" . [] oboInOwl:hasDbXref "Wikipedia:Premaxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002244 ; owl:annotatedTarget "premaxillary bone" . _:genid122569 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002129, obo:UBERON_0002423 . [] oboInOwl:hasDbXref "MP:0009959", "Wikipedia:Cerebellar_hemisphere" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "A paired regions of the cerebellum that lie outside and lateral to the central vermis[MP]. The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres. The lateral hemisphere is considered the portion of the cerebellum to develop most recently. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Hemisphere_of_the_Cerebellum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "UMLS:C0228465" . [] oboInOwl:hasDbXref "FMA:76925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "hemisphere of cerebellum" . _:genid122573 oboInOwl:hasDbXref "FMA:76925", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "hemispherium cerebelli [H II - H X]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006242 . [] oboInOwl:hasDbXref "FMA:76925", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "hemispherium cerebelli [hII-hX]" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "cerebellar hemispheres" . [] oboInOwl:hasDbXref "Wikipedia:Cerebellar_hemisphere" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002245 ; owl:annotatedTarget "hemispherium cerebelli" . [] oboInOwl:hasDbXref "MESH:A07.231.114.681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002250 ; owl:annotatedTarget "The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002250 ; owl:annotatedTarget "EMAPA:37109" . [] oboInOwl:source "ncithesaurus:Popliteal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002250 ; owl:annotatedTarget "UMLS:C0032649" . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002250 ; owl:annotatedTarget "arteria poplitea" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget _:genid123405 . [] oboInOwl:hasDbXref "GO:0021517", "MP:0005112", "Wikipedia:Anterior_horn_of_spinal_cord", "https://sourceforge.net/tracker/?group_id=36855&atid=440764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." . [] oboInOwl:source "Wikipedia:Anterior_horn_of_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "The anterior horn of the spinal cord (or anterior cornu, or anterior column, or ventral horn) is the ventral (front) grey matter section of the spinal cord. The anterior horn contains motor neurons that affect the axial muscles while the posterior horn receives information regarding touch and sensation. The anterior horn is where the cell bodies of alpha motorneurons are located[Wikipedia:Anterior_horn_of_spinal_cord]." . [] oboInOwl:source "BIRNLEX:2668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "UMLS:C0228569" . [] oboInOwl:source "ncithesaurus:Ventral_Horn_of_the_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "UMLS:C0228590" . [] oboInOwl:hasDbXref "FMA:256541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior gray column of spinal cord" . [] oboInOwl:hasDbXref "FMA:256541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior gray horn of spinal cord" . [] oboInOwl:hasDbXref "BIRNLEX:2668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior horn" . [] oboInOwl:hasDbXref "FMA:256541", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "columna grisea anterior medullae spinalis" . [] oboInOwl:hasDbXref "BIRNLEX:2668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "spinal cord anterior horn" . [] oboInOwl:hasDbXref "FMA:256541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral gray column of spinal cord" . [] oboInOwl:hasDbXref "FMA:256541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral gray matter of spinal cord" . [] oboInOwl:hasDbXref "BIRNLEX:2668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral grey horn" . [] oboInOwl:hasDbXref "ZFA:0000702" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral horn spinal cord" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_horn_of_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior column" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:7588651" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_horn_of_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior column of the spinal cord" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_horn_of_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "anterior horn (spinal cord)" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_horn_of_spinal_cord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "cornu anterius medullae spinalis" . [] oboInOwl:hasDbXref "BAMS:VH" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral horn of the spinal cord" . [] oboInOwl:hasDbXref "VHOG:0001288" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002257 ; owl:annotatedTarget "ventral horns spinal cord" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget _:genid123427 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/dorsal+funiculus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "The white substance of the spinal cord lying on either side between the posterior median sulcus and the dorsal root." . [] oboInOwl:hasDbXref "ZFA:0000501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "dorsal funiculus" . [] oboInOwl:hasDbXref "FMA:77461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "dorsal white column of spinal cord" . [] oboInOwl:hasDbXref "ZFA:0000501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "funiculus dorsalis" . [] oboInOwl:hasDbXref "FMA:77461", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "funiculus posterior medullae spinalis" . [] oboInOwl:hasDbXref "FMA:77461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002258 ; owl:annotatedTarget "posterior white column of spinal cord" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget obo:UBERON_0002308 . [] oboInOwl:source "BTO", "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget _:genid123436 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget _:genid123438 . [] oboInOwl:hasDbXref "Wikipedia:Lentiform_nucleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule. [WP,unvetted]." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "the EMAPA class is unclear" . [] oboInOwl:source "ncithesaurus:Lenticular_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "UMLS:C0162342" . [] oboInOwl:hasDbXref "BTO:0002250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "nucleus lenticularis" . [] oboInOwl:hasDbXref "BTO:0002250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "nucleus lentiformis" . [] oboInOwl:hasDbXref "BTO:0002250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "lenticular nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Lentiform_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002263 ; owl:annotatedTarget "nucleus lentiformis" . _:genid122626 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0005366, obo:UBERON_0011143 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget _:genid123450 . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget _:genid123452 . _:genid122629 oboInOwl:hasDbXref "BTO:0000961", "Wikipedia:Olfactory_bulb" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003918 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget obo:UBERON_0001950 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget obo:UBERON_0002421 . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "Part of the rostral part of the cerebrum where axons of olfactory cells from the nasal mucosa terminate. Projects onto olfactory parts of pallium via olfactory tracts" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010165" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "Part of the telencephalon comprised of anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits.[AAO]" . [] oboInOwl:source "FMA:77624" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "Segment of neural tree organ which is continuous with a set of olfactory nerves and an olfactory tract[FMA:77624]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000033" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "The part of the forebrain in which the olfactory nerves end and the olfactory tracts originate. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000033" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.ne.04.030181.001505 Northcutt RG, Evolution of the telencephalon in nonmammals. Ann. Rev. Neurosci. (1981)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "In most vertebrates, the olfactory bulb is the most rostral (forward) part of the brain. In humans, however, the olfactory bulb is on the inferior (bottom) side of the brain. The olfactory bulb is supported and protected by the cribriform plate which in mammals, separates it from the olfactory epithelium, and which is perforated by olfactory nerve axons. The bulb is divided into two distinct structures, the main olfactory bulb, and the accessory olfactory bulb" . [] oboInOwl:source "BIRNLEX:1137", "ncithesaurus:Olfactory_Bulb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "UMLS:C0028936" . [] oboInOwl:source "BIRNLEX:1137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "neuronames:279" . [] oboInOwl:hasDbXref "Wikipedia:Olfactory_bulb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "bulbus olfactorius" . [] oboInOwl:hasDbXref "Wikipedia:Olfactory_bulb" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "bulbus olfactorius" . [] oboInOwl:hasDbXref "NeuroNames:279" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "bulbus olfactorius (Morgagni)" . [] oboInOwl:hasDbXref "ZFA:0000402" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "olfactory lobe" . [] oboInOwl:hasDbXref "NeuroNames:279" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002264 ; owl:annotatedTarget "olfactory lobe (Barr & Kiernan)" . [] oboInOwl:hasDbXref "BIRNLEX:1663", "ISBN:0471888893", "Wikipedia:Olfactory_tract", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "White matter tract that contains projections from the olfactory bulb to other parts of the brain." . _:genid122651 oboInOwl:source "BTO:0003647" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "A nervelike, white band composed primarily of nerve fibres originating from the mitral cells and tufted cells of the olfactory bulb but also containing the scattered cells of the anterior olfactory nucleus[BTO:0003647]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001045 . [] oboInOwl:source "Wikipedia:Olfactory_tract" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. It lies in the olfactory sulcus on the inferior surface of the frontal lobe, and divides posteriorly into two striæ, a medial olfactory stria and a lateral olfactory stria.[Wikipedia]." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "Tract of brain which is continuous with olfactory bulb and the cerebral cortex.[FMA]" . [] oboInOwl:notes "deprecated class" ; oboInOwl:source "BIRNLEX:1663" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "White matter tract that contains projections from the olfactory bulb to the olfactory cortex (Maryann Martone)" . [] oboInOwl:editor "cjm" ; oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "The definition was adapted from the NIFSTD class which has been retired. It has been generalized so it is applicable to various different kinds of olfactory tracts found in different taxa." . [] oboInOwl:source "ncithesaurus:Olfactory_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "UMLS:C0162435" . [] oboInOwl:source "BIRNLEX:1663" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "neuronames:283" . [] oboInOwl:hasDbXref "BTO:0003647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "olfactory peduncle" . [] oboInOwl:hasDbXref "NeuroNames:283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "olfactory stalk" . [] oboInOwl:hasDbXref "NeuroNames:283" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "pedunclulus olfactorius" . [] oboInOwl:hasDbXref "NeuroNames:283" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "tractus olfactorium" . [] oboInOwl:hasDbXref "BTO:0003647", "Wikipedia:Olfactory_tract" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002265 ; owl:annotatedTarget "tractus olfactorius" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ." . [] oboInOwl:hasDbXref "BTO:0001772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "olfactory organ" . [] oboInOwl:hasDbXref "FBbt:00005158" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "olfactory sensory organ" . [] oboInOwl:hasDbXref "BTO:0001772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "olfactory neuroepithelium" . [] oboInOwl:hasDbXref "BTO:0001772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "organ olfactus" . [] oboInOwl:hasDbXref "BTO:0001772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002268 ; owl:annotatedTarget "organum olfactorium" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget _:genid123503 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget _:genid123505 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget _:genid123507 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget _:genid123509 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget _:genid123513 . [] oboInOwl:hasDbXref "Wikipedia:Hyaloid_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005045" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "Artery that is internal to the eye. Isogai et al. 2001.[TAO]" . _:genid122686 oboInOwl:hasDbXref "Wikipedia:Hyaloid_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "arteria hyaloidea" ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003887 . [] oboInOwl:hasDbXref "Wikipedia:Hyaloid_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "Cloquet's canal" . _:genid122688 oboInOwl:hasDbXref "Wikipedia:Hyaloid_artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "Cloquets canal" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005095 . [] oboInOwl:hasDbXref "EMAPA:19242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "central artery of retina" . _:genid122690 oboInOwl:hasDbXref "ZFA:0005045" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002270 ; owl:annotatedTarget "hyaloid arteries" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005721 . [] oboInOwl:hasDbXref "NeuroNames:1223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure" . [] oboInOwl:hasDbXref "NeuroNames:1223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "brain stem reticular formation" . [] oboInOwl:hasDbXref "MA:0003185", "NeuroNames:1223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "brainstem reticular formation" . [] oboInOwl:hasDbXref "NeuroNames:1223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "reticular formation (classical)" . [] oboInOwl:hasDbXref "NeuroNames:1223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002275 ; owl:annotatedTarget "reticular formation of the brainstem" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:8692051" . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_aqueduct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002279 ; owl:annotatedTarget "At the hinder part of the medial wall of the vestibule is the orifice of the vestibular aqueduct, which extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein, and contains a tubular prolongation of the membranous labyrinth, the ductus endolymphaticus, which ends in a cul-de-sac between the layers of the dura mater within the cranial cavity. [WP,unvetted]." . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_aqueduct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002279 ; owl:annotatedTarget "aqueductus vestibuli" . [] oboInOwl:notes "material to immaterial" ; oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget _:genid123541 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000451 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_ventricle", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere." . [] oboInOwl:source "Wikipedia:Lateral_ventricle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "The lateral ventricles are part of the ventricular system of the brain. Classified as part of the telencephalon, they are the largest of the ventricles. The lateral ventricles connect to the central third ventricle through the interventricular foramina of Monro[WP]." . [] oboInOwl:source "GO:0021670" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000643" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:1263", "ncithesaurus:Lateral_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "UMLS:C0152279" . [] oboInOwl:hasDbXref "MA:0000192" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "lateral ventricle" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "lateral ventricles" . [] oboInOwl:hasDbXref "VHOG:0000643", "ZFA:0000696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "telencephalic ventricle" . [] oboInOwl:hasDbXref "EHDAA2:0001984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "telencephalon lateral ventricle" . [] oboInOwl:hasDbXref "BTO:0000879" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "lateral ventricle of brain" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000451 ; owl:annotatedTarget "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." . [] oboInOwl:hasDbXref "BAMS:Tel-V" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "telencephalic ventricles" . [] oboInOwl:hasDbXref "ZFA:0000696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002285 ; owl:annotatedTarget "telencephalic vesicle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget _:genid123556 . [] oboInOwl:hasDbXref "BIRNLEX:714" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000161" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000161" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "relationship loss: develops_from forebrain ventricle (TAO:0001259)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000007" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:source "BIRNLEX:714", "ncithesaurus:Third_Ventricle_of_Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "UMLS:C0149555" . [] oboInOwl:hasDbXref "ZFA:0000161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "ventriculus diencephali" . [] oboInOwl:hasDbXref "Wikipedia:Third_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002286 ; owl:annotatedTarget "ventriculus tertius cerebri" . [] oboInOwl:hasDbXref "NLX:18606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "Part of choroid plexus contained in the third ventricle." . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_of_the_Third_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "UMLS:C0152291" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere of third ventricle" . [] oboInOwl:hasDbXref "ZFA:0001444" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "choroid plexus third ventricle" . [] oboInOwl:hasDbXref "ZFA:0001444" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "diencephalic choroid plexus" . _:genid122742 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002288 ; owl:annotatedTarget "third ventricle chorioid plexus of cerebral hemisphere" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget _:genid123578 . [] oboInOwl:hasDbXref "BIRNLEX:1261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000832" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "Two distinct classes in ncit. We classify this as a brain ventricle even though it is not classifically regarded as one (3rd = diencephalon, 4th = hindbrains)" . [] oboInOwl:source "BIRNLEX:1261", "ncithesaurus:Aqueduct_of_Sylvius" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "UMLS:C0007769" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_aqueduct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "Sylvian aqueduct" . [] oboInOwl:hasDbXref "FMA:78467", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "aqueductus mesencephali" . [] oboInOwl:hasDbXref "ZFA:0000159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "cerebral aquaduct" . [] oboInOwl:hasDbXref "MA:0000208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "cerebral aqueduct" . [] oboInOwl:hasDbXref "ZFA:0000159" ; oboInOwl:hasSynonymType core:NON_AMNIOTE ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "medial tectal ventricle" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_aqueduct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "mesencephalic duct" . [] oboInOwl:hasDbXref "ZFA:0000159" ; oboInOwl:hasSynonymType core:NON_AMNIOTE ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "mesencephalic ventricle" . [] oboInOwl:hasDbXref "EHDAA2:0001163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "midbrain cerebral aqueduct" . [] oboInOwl:hasDbXref "ZFA:0000159" ; oboInOwl:hasSynonymType core:NON_AMNIOTE ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "midbrain ventricle" . _:genid122758 oboInOwl:hasDbXref "ZFA:0000159" ; oboInOwl:hasSynonymType core:NON_AMNIOTE ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "tectal ventricle" ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0007613 . [] oboInOwl:hasDbXref "BAMS:AQ" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "aqueduct" . [] oboInOwl:hasDbXref "BAMS:AQ" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "aqueduct of Sylvius" . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_aqueduct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "aqueductus mesencephali" . [] oboInOwl:hasDbXref "BAMS:AQ" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "cerebral aqueduct proper" . [] oboInOwl:hasDbXref "ZFA:0000159" ; oboInOwl:hasSynonymType core:NON_AMNIOTE ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002289 ; owl:annotatedTarget "mesencephalic vesicle" . [] oboInOwl:hasDbXref "NLX:27388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002290 ; owl:annotatedTarget "Choroid plexus of the fourth ventricle." . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_of_the_Fourth_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002290 ; owl:annotatedTarget "UMLS:C0152293" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002290 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere of fourth ventricle" . [] oboInOwl:hasDbXref "ZFA:0001446" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002290 ; owl:annotatedTarget "choroid plexus fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002290 ; owl:annotatedTarget "fourth ventricle chorioid plexus of cerebral hemisphere" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget obo:UBERON_0004111 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget _:genid123610 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget _:genid123612 . [] oboInOwl:hasDbXref "PMID:23409159", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." . [] oboInOwl:source "ncithesaurus:Central_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "UMLS:C0459414" . [] oboInOwl:hasDbXref "ZFA:0000938" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "canalis centralis" . [] oboInOwl:hasDbXref "ZFA:0000938" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "central canal" . [] oboInOwl:hasDbXref "FMA:78497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "ventricle of spinal cord" . [] oboInOwl:hasDbXref "BAMS:C" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002291 ; owl:annotatedTarget "central canal, spinal cord/medulla" . _:genid122793 oboInOwl:source "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget obo:UBERON_0002001 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011820 . [] oboInOwl:hasDbXref "HP:0000920", "Wikipedia:Costochondral_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "A bars of hyaline cartilage located between the distal part of a rib and a costal cartilage, connecting the ribs to the sternum ." . [] oboInOwl:source "ncithesaurus:Costochondral_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "UMLS:C0224683" . [] oboInOwl:hasDbXref "FMA:7956", "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "articulatio costochondralis" . [] oboInOwl:hasDbXref "FMA:7956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "chondrocostal synchondrosis" . _:genid122798 oboInOwl:hasDbXref "FMA:7956", "HP:0000920" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "costochondral junction" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002062 . [] oboInOwl:hasDbXref "FMA:7956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "costochondral synchondrosis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:8818047" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000453 ; owl:annotatedTarget obo:CL_0000990 . _:genid122800 oboInOwl:hasDbXref "Wikipedia:Costochondral_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002293 ; owl:annotatedTarget "articulationes costochondrales" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004292 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149", "PMCID:PMC2346585", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000453 ; owl:annotatedTarget "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." . [] oboInOwl:hasDbXref "Wikipedia:Biliary_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002294 ; owl:annotatedTarget "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." . [] oboInOwl:hasDbXref "FMA:79646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002294 ; owl:annotatedTarget "biliary apparatus" . [] oboInOwl:hasDbXref "FMA:79646", "MA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002294 ; owl:annotatedTarget "biliary tract" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget obo:UBERON_0002050 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget _:genid123651 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_mesentery", "Wikipedia:Mesentery#Development", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005130" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget "The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO]" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget "dorsal mesogastrium" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_mesentery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002296 ; owl:annotatedTarget "mesenterium dorsale commune" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget obo:UBERON_0000481 . _:genid122826 oboInOwl:hasDbXref "ISBN:0471888893", "MP:0005277", "Wikipedia:Brainstem", "ZFA:0001707" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002079 . [] oboInOwl:notes "we apply a strict definition" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget obo:UBERON_0001890 . _:genid122828 oboInOwl:exceptions "ZFA" ; oboInOwl:source "ABA", "https://github.com/obophenotype/uberon/issues/378" ; oboInOwl:status "pending" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget obo:UBERON_0002037 ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002084 . [] oboInOwl:notes "we apply a strict definition" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget obo:UBERON_0002314 . _:genid122830 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002156" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ISBN:3764351209" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO]" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0005995 . [] oboInOwl:source "ZFA:0001707" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]." . [] oboInOwl:source "MP:0005277" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP]" . [] oboInOwl:source "BIRNLEX:1565", "ncithesaurus:Brain_Stem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "UMLS:C0006121" . [] oboInOwl:source "BIRNLEX:1565" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "neuronames:236" . [] oboInOwl:hasDbXref "ABA:BS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "brain stem" . [] oboInOwl:hasDbXref "Wikipedia:Brainstem" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "truncus encephali" . [] oboInOwl:hasDbXref "NeuroNames:236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "accessory medullary lamina of pallidum" . [] oboInOwl:hasDbXref "NeuroNames:236" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "lamella pallidi incompleta" . [] oboInOwl:hasDbXref "NeuroNames:236" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "lamina medullaris accessoria" . [] oboInOwl:hasDbXref "NeuroNames:236" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "lamina medullaris incompleta pallidi" . [] oboInOwl:hasDbXref "NeuroNames:236" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "lamina pallidi incompleta" . [] oboInOwl:hasDbXref "BTO:0000146" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002298 ; owl:annotatedTarget "truncus encephalicus" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget _:genid123685 . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_alveolus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_alveolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "alveolus pulmonis" . [] oboInOwl:hasDbXref "FMA:7318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "pulmonary alveolus" . [] oboInOwl:hasDbXref "BTO:0000060" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "alveoli" . _:genid122855 oboInOwl:hasDbXref "Wikipedia:Pulmonary_alveolus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "alveolus pulmonis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002299 ; owl:annotatedTarget "respiratory alveoli" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12438093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000454 ; owl:annotatedTarget "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." . [] oboInOwl:hasDbXref "ISBN-10:0-87893-742-0", "PMID:29081739", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002301 ; owl:annotatedTarget "One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets." . [] oboInOwl:hasDbXref "FMA:83138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002301 ; owl:annotatedTarget "layer of neocortex" . [] oboInOwl:hasDbXref "MA:0000186" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002301 ; owl:annotatedTarget "neocortex layer" . [] oboInOwl:hasDbXref "MA:0000186" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002301 ; owl:annotatedTarget "cerebral cortex layer" . [] oboInOwl:hasDbXref "FMA:83138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002301 ; owl:annotatedTarget "lamina of neocortex" . [] oboInOwl:hasDbXref "GO:0048242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000454 ; owl:annotatedTarget "adrenaline secreting cell" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002302 ; owl:annotatedTarget "The atrial part of middle layer of the heart, comprised of involuntary muscle." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000602" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002302 ; owl:annotatedTarget "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001374" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002302 ; owl:annotatedTarget "atrial myocardium" . [] oboInOwl:hasDbXref "VHOG:0000602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002302 ; owl:annotatedTarget "atrium cardiac muscle" . _:genid122875 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0016548 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002421 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 . ( ) . [] oboInOwl:hasDbXref "MP:0000813", "Wikipedia:Hippocampus_anatomy#Hippocampal_Cells_and_Layers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002305 ; owl:annotatedTarget "The layers of the laminar structure of the hippocampus." . [] oboInOwl:hasDbXref "BIRNLEX:1192" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002305 ; owl:annotatedTarget "cytoarchitectural fields of hippocampal formation" . [] oboInOwl:hasDbXref "FMA:83679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002305 ; owl:annotatedTarget "hippocampus proper layer" . [] oboInOwl:hasDbXref "FMA:83679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002305 ; owl:annotatedTarget "layer of cornu ammonis" . [] oboInOwl:hasDbXref "NLX:32548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002307 ; owl:annotatedTarget "Part of choroid plexus contained in the lateral ventricle." . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_of_the_Lateral_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002307 ; owl:annotatedTarget "UMLS:C0152289" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002307 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere of lateral ventricle" . [] oboInOwl:hasDbXref "ZFA:0001447" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002307 ; owl:annotatedTarget "choroid plexus telencephalic ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002307 ; owl:annotatedTarget "lateral ventricle chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002308 ; owl:annotatedTarget "A neural nucleus that is part of the brain." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "PMID:9635063" . [] oboInOwl:source "ncithesaurus:Brain_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002308 ; owl:annotatedTarget "UMLS:C1706993" . [] oboInOwl:hasDbXref "ZFA:0005575" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002308 ; owl:annotatedTarget "brain nuclei" . [] oboInOwl:hasDbXref "MP:0008503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." . [] oboInOwl:source "ncithesaurus:Gray_Matter_of_the_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "UMLS:C0475853" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "gray matter of spinal cord" . [] oboInOwl:hasDbXref "FMA:256580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "gray substance of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "spinal cord gray matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "spinal cord grey substance" . [] oboInOwl:hasDbXref "FMA:256580", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002315 ; owl:annotatedTarget "substantia grisea medullae spinalis" . _:genid122916 oboInOwl:hasDbXref "Wikipedia:White_matter", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002567 . [] oboInOwl:source "FMA:83929" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002142" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "Multi-tissue structure comprised largely of myelinated axons.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001764" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature09614 Nave KA, Myelination and support of axonal integrity by glia. Nature (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" . [] oboInOwl:external_ontology "NIF" ; oboInOwl:seeAlso "https://github.com/SciCrunch/NIF-Ontology/issues/83" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "nlx_anat_101177 seems to have been lost in the transition from NIFGA to Neurolex" . [] oboInOwl:source "ncithesaurus:White_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "UMLS:C0682708" . [] oboInOwl:hasDbXref "ZFA:0001682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "CNS tract/commissure" . [] oboInOwl:hasDbXref "AEO:0001011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "neuronal white matter" . [] oboInOwl:hasDbXref "FMA:83929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "white matter of neuraxis" . [] oboInOwl:hasDbXref "TAO:0000145" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "CNS tracts and commissures" . [] oboInOwl:hasDbXref "TAO:0002143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "CNS white matter" . [] oboInOwl:hasDbXref "Wikipedia:White_matter" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "substantia alba" . [] oboInOwl:hasDbXref "VHOG:0001764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002316 ; owl:annotatedTarget "white mater" . [] oboInOwl:source "FMA-weakened", "MA-weakened" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget _:genid123768 . [] oboInOwl:hasDbXref "BIRNLEX:1562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "Regional part of cerebellum consisting of the myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles." . _:genid122931 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002183" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "CNS white matter that is part of the cerebellum.[TAO]" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007280 . [] oboInOwl:external_ontology "NIF" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "in NIF this is a composite structure; in MA and FMA it is explicitly part of cerebellum. This leads to consistency problems with strict parcellation schemes like ABA, see cerebellar peduncles. In NIF this is a composite structure, this is followed partially here in weakening the relationship to overlaps" . [] oboInOwl:source "BIRNLEX:1562", "ncithesaurus:Cerebellum_White_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "UMLS:C0152381" . [] oboInOwl:source "BIRNLEX:1562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "neuronames:691" . [] oboInOwl:hasDbXref "ZFA:0001708" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "cerebellar tracts/commissures" . [] oboInOwl:hasDbXref "NeuroNames:691" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "medullary substance of cerebellum" . [] oboInOwl:hasDbXref "NeuroNames:691" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "substantia centralis medullaris cerebelli" . [] oboInOwl:hasDbXref "NeuroNames:691" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002317 ; owl:annotatedTarget "substantia medullaris cerebelli" . [] oboInOwl:hasDbXref "MP:0008027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." . [] oboInOwl:source "ncithesaurus:White_Matter_of_the_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "UMLS:C0458457" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "spinal cord white matter of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "spinal cord white substance" . [] oboInOwl:hasDbXref "FMA:83945", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "substantia alba medullae spinalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "white matter of neuraxis of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002318 ; owl:annotatedTarget "white substance of spinal cord" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19630576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000458 ; owl:annotatedTarget "A cell type that secretes 5-Hydroxytryptamine (serotonin)." . [] oboInOwl:hasDbXref "Wikipedia:Mesangium", "https://sourceforge.net/p/obo/foundational-model-of-anatomy-fma-requests/13/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002319 ; owl:annotatedTarget "The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002319 ; owl:annotatedTarget "WP considers this the same as glomerular mesangium. In MA, glomerular and extraglomerular are distingsuished. FMA class has no definition and is a type of stroma, which is inconsistent with our classification of this here." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002319 ; owl:annotatedTarget "EMAPA:36561" . [] oboInOwl:source "ncithesaurus:Mesangium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002319 ; owl:annotatedTarget "UMLS:C0017655" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget _:genid123804 . [] oboInOwl:hasDbXref "BTO:0001707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." . [] oboInOwl:date_retrieved "2012-09-12" ; oboInOwl:external_class "ZFA:0001438" ; oboInOwl:ontology "ZFA" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]." . [] oboInOwl:date_retrieved "2012-09-12" ; oboInOwl:external_class "BTO:0001707" ; oboInOwl:ontology "BTO" ; oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]." . [] oboInOwl:hasDbXref "BTO:0001707" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "body cavity" . [] oboInOwl:source "ncithesaurus:Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "UMLS:C0333343" . [] oboInOwl:hasDbXref "EHDAA2:0000267" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "coelomic cavity" . [] oboInOwl:hasDbXref "EHDAA2:0000267" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "coelomic cavity lumen" . [] oboInOwl:hasDbXref "FMA:85006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "space of body compartment" . [] oboInOwl:hasDbXref "NCBITaxon:7742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "ventral body cavity" . _:genid122975 oboInOwl:hasDbXref "BTO:0001707" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "celom" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006524 . [] oboInOwl:hasDbXref "BTO:0001707" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "coelome" . _:genid122977 oboInOwl:hasDbXref "FBbt:00005060" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002323 ; owl:annotatedTarget "hemocoel" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008874 . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002324 ; owl:annotatedTarget _:genid123824 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002324 ; owl:annotatedTarget "Any muscle organ that is part of a back [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002324 ; owl:annotatedTarget "back muscle organ" . _:genid122986 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002324 ; owl:annotatedTarget "muscle organ of back" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002318 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "GO:0061071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.." . [] oboInOwl:source "ncithesaurus:Urethra_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "UMLS:C1710584" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "epithelial tissue of urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "urethra epithelial tissue" . [] oboInOwl:hasDbXref "EMAPA:31518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "urethral plate" . [] oboInOwl:hasDbXref "EMAPA:31518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002325 ; owl:annotatedTarget "urethral seam" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Reaxys:1751215" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "A lamina propria that is part of a urethra [Automatically generated definition]." . _:genid123004 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "EMAPA:37785" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "lamina propria mucosa of urethra" . _:genid123006 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "lamina propria mucosae of urethra" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010368 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "urethra lamina propria mucosa" . _:genid123008 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002326 ; owl:annotatedTarget "urethra lamina propria mucosae" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0007196 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000459 ; owl:annotatedTarget "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002327 ; owl:annotatedTarget "EMAPA:37720" . [] oboInOwl:source "PMID:15890825" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget obo:UBERON_0000062 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget _:genid123861 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget _:genid123863 . [] oboInOwl:hasDbXref "ISBN:0815318960", "Wikipedia:Notochord", "http://tolweb.org/Chordata/2499", "https://github.com/obophenotype/uberon/issues/25", "https://github.com/obophenotype/uberon/issues/271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000032" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000135" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000327" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000327" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000199" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Notochord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "UMLS:C0028439" . [] oboInOwl:hasDbXref "ZFA:0000135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "notocord" . [] oboInOwl:hasDbXref "Wikipedia:Notochord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002328 ; owl:annotatedTarget "notochorda" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget obo:UBERON_0007503 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget _:genid123877 . [] oboInOwl:hasDbXref "DOI:10.1111/j.1439-0426.2012.01987.x", "Wikipedia:Somite" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010569" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000155" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000155" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000155" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010569" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000191" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.40, DOI:10.1093/icb/43.1.137 Balavoine G, Adoutte A, The segmented urbilateria: a testable scenario. Integrative and Comparative Biology (2003)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "(...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "GO:0001756" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "mesodermal cluster" . [] oboInOwl:source "ncithesaurus:Somite" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "UMLS:C0376449" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "epimere" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "epithelial somite" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "somites" . [] oboInOwl:hasDbXref "Wikipedia:Somite" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002329 ; owl:annotatedTarget "somitus" . [] oboInOwl:hasDbXref "Wikipedia:Exocrine_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002330 ; owl:annotatedTarget "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." . [] oboInOwl:source "ncithesaurus:Exocrine_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002330 ; owl:annotatedTarget "UMLS:C1516995" . [] oboInOwl:hasDbXref "EHDAA2:0002225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002330 ; owl:annotatedTarget "exocrine glandular system" . _:genid123055 oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001725", "PMID:9144284", "Wikipedia:Umbilical_cord" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "The connecting cord from the developing embryo to the placenta." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000295 . [] oboInOwl:source "Wikipedia:Umbilical_cord" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP]." . [] oboInOwl:source "ncithesaurus:Umbilical_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "UMLS:C0041633" . _:genid123058 oboInOwl:hasDbXref "MP:0012134" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "chorda umbilicalis" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000439 . [] oboInOwl:hasDbXref "MP:0012134" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "funiculus umbilicalis" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." . _:genid123060 oboInOwl:hasDbXref "Wikipedia:Umbilical_cord" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "birth cord" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000467 . [] oboInOwl:hasDbXref "Wikipedia:Umbilical_cord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "funiculus umbilicalis" . [] oboInOwl:hasDbXref "BTO:0001415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002331 ; owl:annotatedTarget "yolk stalk" . _:genid123063 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008886, obo:UBERON_0009122 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002333 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002333 ; owl:annotatedTarget "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001134" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pulmonary+trunk" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002333 ; owl:annotatedTarget "An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001134" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002333 ; owl:annotatedTarget "As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG]" . [] oboInOwl:hasDbXref "GO:0051458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "ACTH secreting cell" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002333 ; owl:annotatedTarget "main pulmonary artery" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0009525" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "The duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "FMA also has 'main submandibular duct' (FMA:59899)" . [] oboInOwl:source "ncithesaurus:Submandibular_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "UMLS:C0227472" . [] oboInOwl:hasDbXref "GO:0051458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000467 ; owl:annotatedTarget "corticotropin secreting cell" . [] oboInOwl:hasDbXref "FMA:59899", "Wikipedia:Submandibular_duct" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "Wharton's duct" . [] oboInOwl:hasDbXref "BTO:0004556" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "ductus submandibularis" . [] oboInOwl:hasDbXref "Wikipedia:Submandibular_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "ductus submaxillaris" . [] oboInOwl:hasDbXref "BTO:0004556" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002334 ; owl:annotatedTarget "submaxillar gland duct" . [] oboInOwl:source "FMA-part_of", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget obo:UBERON_0002473 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget obo:UBERON_0005340 . _:genid123087 oboInOwl:hasDbXref "BIRNLEX:1087" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget "White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres.it is subdivided into a genu, a rostrum, a body, and a splenium. (MM)." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000007 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001608" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/corpus+callosum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget "The largest commissure of the brain connecting the cerebral hemispheres. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001608" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1749-6632.1969.tb20447.x Ebner FF, A comparison of primitive forebrain organization in metatherian and eutherian mammals. Annals of the New York Academy of Sciences (1969)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget "In addition to the anterior commissure, placental mammals have a phylogenetically new forebrain commissure, the corpus callosum, which primarily interconnects the neocortex of the cerebral hemispheres.[well established][VHOG]" . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000473 ; owl:annotatedTarget "A cell whose primary function is to protect the organism." . _:genid123090 oboInOwl:source "Wikipedia:Corpus_callosum#Species_Differences" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget "The corpus callosum is found only in placental mammals. other groups do have other brain structures that allow for communication between the two hemispheres, such as the anterior commissure, which serves as the primary mode of interhemispheric communication in marsupials." ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001992 . [] oboInOwl:source "BIRNLEX:1087", "ncithesaurus:Corpus_Callosum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002336 ; owl:annotatedTarget "UMLS:C0010090" . _:genid123092 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003891 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001295 ] ) ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0030103 . [] oboInOwl:hasDbXref "ncithesaurus:Endometrial_Stroma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002337 ; owl:annotatedTarget "The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle." . [] oboInOwl:source "ncithesaurus:Endometrial_Stroma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002337 ; owl:annotatedTarget "UMLS:C0227849" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "2-aminoethanesulfonic acid" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget _:genid123947 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "A lamina propria that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchus_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "UMLS:C1707054" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchi lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchi lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchi lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchial trunk lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchial trunk lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchial trunk lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchus lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchus lamina propria mucosae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosa of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosa of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosa of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosae of bronchi" . _:genid123118 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosae of bronchial trunk" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria mucosae of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "lamina propria of bronchial trunk" . [] oboInOwl:hasDbXref "EMAPA:35194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002338 ; owl:annotatedTarget "bronchial lamina propria" . [] oboInOwl:source "XAO", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget _:genid123969 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget _:genid123971 . [] oboInOwl:source "PMID:11523831" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget _:genid123973 . [] oboInOwl:notes "pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget _:genid123975 . [] oboInOwl:source "PMID:11523831" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget _:genid123977 . [] oboInOwl:hasDbXref "MP:0009846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." . [] oboInOwl:source "ISBN:0073040584", "PMID:17377535" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002174 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget obo:NCBITaxon_117565 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000045" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010578" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO]" . [] oboInOwl:source "PMID:11523831" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000057" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Neural_Crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "UMLS:C0027789" . [] oboInOwl:hasDbXref "XAO:0000048" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "NC" . [] oboInOwl:hasDbXref "Wikipedia:Neural_crest" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "crista neuralis" . [] oboInOwl:hasDbXref "VHOG:0000057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002342 ; owl:annotatedTarget "neural crest material" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000484 ; owl:annotatedTarget obo:CL_0000097 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002343 ; owl:annotatedTarget "Set of all muscles in abdomen." . [] oboInOwl:hasDbXref "FMA:71294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002343 ; owl:annotatedTarget "muscle group of abdomen" . [] oboInOwl:hasDbXref "FMA:71294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002343 ; owl:annotatedTarget "muscles of abdomen" . [] oboInOwl:hasDbXref "FMA:86917" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002343 ; owl:annotatedTarget "musculature of abdominal wall" . [] oboInOwl:hasDbXref "FMA:71294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002343 ; owl:annotatedTarget "set of muscles of abdomen" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19923473", "PMID:9354811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000484 ; owl:annotatedTarget "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." . [] oboInOwl:hasDbXref "MP:0009868" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002345 ; owl:annotatedTarget "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget _:genid124004 . [] oboInOwl:hasDbXref "Wikipedia:Neuroectoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget "Embryonic ectoderm that gives rise to nervous tissue." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000150" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget "(...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Neuroectoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget "UMLS:C1518271" . [] oboInOwl:hasDbXref "Wikipedia:Neuroectoderm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget "epithelium tubi neuralis; neuroectoderma" . [] oboInOwl:hasDbXref "VHOG:0000150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002346 ; owl:annotatedTarget "ventral neurogenic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002347 ; owl:annotatedTarget "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." . [] oboInOwl:source "ncithesaurus:Thoracic_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002347 ; owl:annotatedTarget "UMLS:C0039987" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002347 ; owl:annotatedTarget "thorax vertebra" . _:genid123168 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002347 ; owl:annotatedTarget "vertebra of thorax" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003314 . [] oboInOwl:source "multiple" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget _:genid124021 . [] oboInOwl:source "FMA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget _:genid124023 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget _:genid124026 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005057" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "External layer of the heart.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010409" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "The inner layer of the pericardium that is in contact with the surface of the heart.[AAO]" . [] oboInOwl:source "ncithesaurus:Epicardium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "UMLS:C0225968" . [] oboInOwl:hasDbXref "FMA:9461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "visceral serous pericardium of heart" . _:genid123178 oboInOwl:hasDbXref "FMA:9461" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "visceral serous pericardium proper" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "EMAPA:16589" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002348 ; owl:annotatedTarget "pericardium visceral mesothelium" . _:genid123186 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002159 ; owl:someValuesFrom obo:UBERON_0002208, obo:UBERON_0002350 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0005329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000083" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010410" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "The middle layer of the heart, consisting of cardiac muscle.[AAO]" . [] oboInOwl:source "ncithesaurus:Myocardium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "UMLS:C0027061" . [] oboInOwl:hasDbXref "FMA:9462" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "muscle of heart" . [] oboInOwl:hasDbXref "ZFA:0001319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "cardiac muscle" . [] oboInOwl:hasDbXref "FMA:9462", "ZFA:0001319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002349 ; owl:annotatedTarget "heart muscle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget obo:UBERON_0010131 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124050 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124052 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124054 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124056 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Taurine" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000488 ; owl:annotatedTarget "A photoreceptor cell that detects visible light." . _:genid123200 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124058 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000975 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget _:genid124060 . [] oboInOwl:hasDbXref "GO:0003161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001271" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "cardiac conducting system" . [] oboInOwl:hasDbXref "GO:0003161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "cardiac impulse conducting system" . _:genid123206 oboInOwl:hasDbXref "FMA:9476", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "complexus stimulans cordis" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002320 . [] oboInOwl:hasDbXref "GO:0003161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "heart conduction system" . [] oboInOwl:hasDbXref "MA:0000094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "impulse conducting system" . [] oboInOwl:hasDbXref "FMA:9476", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002350 ; owl:annotatedTarget "systema conducente cordis" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget obo:UBERON_0010131 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget _:genid124073 . [] oboInOwl:hasDbXref "GO:0003163", "Wikipedia:Sinoatrial_node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." . [] oboInOwl:source "ncithesaurus:Sinoatrial_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "UMLS:C0037189" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "Koch's node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "SA nodal muscle tissue" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "SA node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "cardiac pacemaker" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "node of Keith-Flack" . [] oboInOwl:hasDbXref "FMA:9477", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "nodus sinuatrialis" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinoatrial node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinu-atrial node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinuatrial nodal muscle tissue" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinuatrial node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinus node" . [] oboInOwl:hasDbXref "FMA:9477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "sinus node of Keith and Flack" . [] oboInOwl:hasDbXref "Wikipedia:Sinoatrial_node" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002351 ; owl:annotatedTarget "nodus sinuatrialis" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget obo:UBERON_0010131 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Atrioventricular_node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001474" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Atrioventricular_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "UMLS:C0004247" . [] oboInOwl:hasDbXref "FMA:9478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "AV nodal muscle tissue" . [] oboInOwl:hasDbXref "FMA:9478", "MA:0000095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "AV node" . _:genid123242 oboInOwl:hasDbXref "FMA:9478" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "Aschoff-Tawara node" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 . [] oboInOwl:hasDbXref "FMA:9478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "atrioventricular nodal muscle tissue" . [] oboInOwl:hasDbXref "FMA:9478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "node of Tawara" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "nodus atrioventricularis" . [] oboInOwl:hasDbXref "EMAPA:35153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "A-V node" . [] oboInOwl:hasDbXref "EMAPA:35153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "atrio-ventricular node" . [] oboInOwl:hasDbXref "TAO:0005070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "atriovetricular node" . [] oboInOwl:hasDbXref "ZFA:0005070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "downstream pacemaker" . [] oboInOwl:hasDbXref "Wikipedia:Atrioventricular_node" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002352 ; owl:annotatedTarget "nodus atrioventricularis" . [] oboInOwl:hasDbXref "Wikipedia:Pelvis", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "MA and FMA differ in what they consider to be parts of the pelvis. MA includes ureter, urethra, urinary bladder, reproductive organs" . [] oboInOwl:source "ncithesaurus:Pelvis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "UMLS:C0030797" . [] oboInOwl:hasDbXref "FMA:9578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "lesser pelvis" . [] oboInOwl:hasDbXref "FMA:9578", "MA:0000030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "pelvis" . [] oboInOwl:hasDbXref "FMA:9578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002355 ; owl:annotatedTarget "true pelvis" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget obo:UBERON_0009569 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget _:genid124123 . [] oboInOwl:hasDbXref "FMA:9579", "Wikipedia:Perineum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget "Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, abdomen, and pelvis, it constitutes the trunk[FMA]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget "FMA has class anal part of perineum, which may be the same as what EHDAA2 calls perineum" . [] oboInOwl:source "ncithesaurus:Perineum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget "UMLS:C0031066" . _:genid123265 oboInOwl:hasDbXref "FMA:9579", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002356 ; owl:annotatedTarget "regio perinealis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006288 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002357 ; owl:annotatedTarget _:genid124129 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002357 ; owl:annotatedTarget _:genid124133 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000492 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "Wikipedia:Serous_pericardium", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002357 ; owl:annotatedTarget "Serous membrane which is divided into parietal and visceral serous pericardium." . [] oboInOwl:hasDbXref "FMA:9582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002357 ; owl:annotatedTarget "serous portion of pericardium" . _:genid123272 oboInOwl:hasDbXref "Wikipedia:Serous_pericardium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002357 ; owl:annotatedTarget "pericardium serosum" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010388 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget _:genid124142 . [] oboInOwl:hasDbXref "VHOG:0001257" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "A serous membrane that lines the peritoneal cavity[VHOG,modified]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "MESH:D006377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000492 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005120" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "An epithelium that lines the peritoneal cavity.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010814" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:JMG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "todo: check MA/EMAPA." . [] oboInOwl:source "ncithesaurus:Peritoneum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "UMLS:C0031153" . [] oboInOwl:hasDbXref "VHOG:0001257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002358 ; owl:annotatedTarget "peritonaeum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002359 ; owl:annotatedTarget obo:UBERON_0000094 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002359 ; owl:annotatedTarget _:genid124152 . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002359 ; owl:annotatedTarget _:genid124155 . [] oboInOwl:hasDbXref "FMA:9586" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002359 ; owl:annotatedTarget "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." . [] oboInOwl:hasDbXref "GOC:tfm", "http://en.wikipedia.org/wiki/Interneuron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000498 ; owl:annotatedTarget "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_pericardium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002359 ; owl:annotatedTarget "pericardium fibrosum" . _:genid123292 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002231, obo:UBERON_0002384 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget obo:UBERON_0000094 . _:genid123294 oboInOwl:source "Bgee:AN" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget _:genid124162 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010388 . [] oboInOwl:hasDbXref "FMA:9589", "Wikipedia:Meninx", "http://www.shsu.edu/~bio_mlt/Chap15.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "Membrane organ that surrounds the brain and the spinal cord." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001295" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/meninges" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "Membrane covering the brain and spinal cord. It is represented by a single layer in fishes, two in amphibians, reptiles and birds and three in mammals (named dura mater, arachnoid and pia mater). [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001295" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/1261" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "Not consider part of the CNS/neuraxis in FMA" . [] oboInOwl:source "ncithesaurus:Meninges" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "UMLS:C0025285" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "2-Aminoethanesulfonic acid" . [] oboInOwl:hasDbXref "VHOG:0001295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002360 ; owl:annotatedTarget "meninx primitiva" . [] oboInOwl:hasDbXref "NLXANAT:090209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002361 ; owl:annotatedTarget "The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals." . [] oboInOwl:source "Wikipedia:Pia_mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002361 ; owl:annotatedTarget "delicate innermost layer of the meninges-the membranes surrounding the brain and spinal cord. The thin, mesh-like pia mater closely envelops the entire surface of the brain, running down into the fissures of the cortex. It joins with the ependyma which lines the ventricles to form choroid plexuses that produce cerebrospinal fluid. In the spinal cord, the pia mater attaches to the dura mater by the denticular ligaments through the arachnoid membrane. The pia mater is a neural crest derivative[Wikipedia:Pia_mater]." . [] oboInOwl:source "ncithesaurus:Pia_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002361 ; owl:annotatedTarget "UMLS:C0031869" . [] oboInOwl:hasDbXref "NLXANAT:090209" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002361 ; owl:annotatedTarget "pial membrane" . [] oboInOwl:hasDbXref "NLXANAT:090209" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002361 ; owl:annotatedTarget "pia" . [] oboInOwl:hasDbXref "ISBN:0471888893", "Wikipedia:Arachnoid_mater" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002362 ; owl:annotatedTarget "A think avascular meningeal layer, between the pia mater and the dural mater. It is separated from the pia mater by the subarachnoid space." . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002362 ; owl:annotatedTarget obo:UBERON_0002049 . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D017154" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000499 ; owl:annotatedTarget "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." . [] oboInOwl:source "ncithesaurus:Arachnoid_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002362 ; owl:annotatedTarget "UMLS:C1510935" . [] oboInOwl:hasDbXref "NLXANAT:090208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002362 ; owl:annotatedTarget "arachnoid membrane" . [] oboInOwl:hasDbXref "BTO:0001636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002362 ; owl:annotatedTarget "arachnoidea mater" . [] oboInOwl:source "PMID:16496288" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget _:genid124182 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget _:genid124185 . [] oboInOwl:hasDbXref "NLXANAT:090206" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget "Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections." . [] oboInOwl:source "Wikipedia:Dura_mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget "the outermost of the three layers of the meninges surrounding the brain and spinal cord. The other two meningeal layers are the pia mater and the arachnoid mater. The dura surrounds the brain and the spinal cord and is responsible for keeping in the cerebrospinal fluid[Wikipedia:Dura_mater]." . [] oboInOwl:source "ncithesaurus:Dura_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget "UMLS:C0013313" . [] oboInOwl:hasDbXref "NLXANAT:090206" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget "pachymeninges" . [] oboInOwl:hasDbXref "BTO:0001637" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002363 ; owl:annotatedTarget "dura" . _:genid123325 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002433 ; owl:someValuesFrom obo:CL_0005000, obo:UBERON_0001756 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget obo:UBERON_0000094 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget _:genid124193 . _:genid123328 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget _:genid124199 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003853 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget _:genid124201 . [] oboInOwl:hasDbXref "MESH:D019864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000502 ; owl:annotatedTarget "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." . _:genid123330 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget _:genid124203 ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006241 . [] oboInOwl:hasDbXref "PMID:11237469", "Wikipedia:Tympanic_membrane" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001146" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "The thin membrane which closes externally the cavity of the middle ear and is deeply sited at the bottom of the external auditory meatus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001146" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.418", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "In particular, a tympanic membrane was not present in the earliest tetrapods (...). An ear utilizing a tympanic membrane evolved independently at least three times in tetrapods: (1) in the lineage that leads to anurans (frogs), (2) in the line of evolution to turtles and diapsids, and (3) in the late synapsid lineage that gave rise to mammals.[well established][VHOG]" . [] oboInOwl:source "PMID:11237469" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "most AOs consider this part of the middle ear, so we go with this and place it in the middle ear as a border to the external, although it could be considered to overlap the external ear in that it has an EAM layer as part - for this reason we do not consider middle and external ear to be spatially disjoint." . [] oboInOwl:source "ncithesaurus:Tympanic_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "UMLS:C0041445" . [] oboInOwl:hasDbXref "FMA:9595", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "paries membranaceus cavi tympani" . [] oboInOwl:hasDbXref "Wikipedia:Tympanic_membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002364 ; owl:annotatedTarget "tympanum" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000506 ; owl:annotatedTarget "An endorphine cell that secretes enkephalin." . [] oboInOwl:hasDbXref "Wikipedia:Exocrine_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002365 ; owl:annotatedTarget "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." . [] oboInOwl:source "ncithesaurus:Exocrine_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002365 ; owl:annotatedTarget "UMLS:C0015282" . [] oboInOwl:hasDbXref "AEO:0000097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002365 ; owl:annotatedTarget "ducted gland" . [] oboInOwl:hasDbXref "Wikipedia:Exocrine_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002365 ; owl:annotatedTarget "glandula exocrina" . [] oboInOwl:hasDbXref "GO:0030850", "Wikipedia:Prostate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002367 ; owl:annotatedTarget "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." . [] oboInOwl:source "ncithesaurus:Prostate_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002367 ; owl:annotatedTarget "UMLS:C0033572" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000507 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes endorphin." . [] oboInOwl:hasDbXref "PMID:10668204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002367 ; owl:annotatedTarget "male prostate" . [] oboInOwl:hasDbXref "Wikipedia:Prostate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002367 ; owl:annotatedTarget "prostata" . _:genid123357 oboInOwl:hasDbXref "Wikipedia:Endocrine_gland" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002368 ; owl:annotatedTarget "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002328 . [] oboInOwl:source "ncithesaurus:Endocrine_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002368 ; owl:annotatedTarget "UMLS:C0014133" . [] oboInOwl:hasDbXref "AEO:0000098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002368 ; owl:annotatedTarget "ductless gland" . [] oboInOwl:hasDbXref "Wikipedia:Ductless_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002368 ; owl:annotatedTarget "ductless gland" . [] oboInOwl:hasDbXref "Wikipedia:Endocrine_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002368 ; owl:annotatedTarget "glandulae endocrinae" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget _:genid124239 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget _:genid124241 . _:genid123366 oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget _:genid124243 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "BTO:0000047", "Wikipedia:Adrenal_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." . _:genid123368 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010551" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001141" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "MESH:D019863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000508 ; owl:annotatedTarget "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." . [] oboInOwl:source "ncithesaurus:Adrenal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "UMLS:C0001625" . _:genid123371 oboInOwl:hasDbXref "Wikipedia:Adrenal_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "glandula adrenalis" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0011628 . [] oboInOwl:hasDbXref "Wikipedia:Adrenal_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "glandula suprarenalis" . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "adrenal" . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "adrenal capsule" . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "atrabiliary capsule" . [] oboInOwl:hasDbXref "Wikipedia:Adrenal_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "epinephric gland" . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "epinephros" . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "glandula suprarenalis" . [] oboInOwl:hasDbXref "GO:0030325" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "interrenal gland" . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000509 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes gastrin." . [] oboInOwl:hasDbXref "BTO:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "suprarenal capsule" . [] oboInOwl:hasDbXref "Wikipedia:Adrenal_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002369 ; owl:annotatedTarget "suprarenal gland" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget obo:UBERON_0002368 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget _:genid124262 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget _:genid124264 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget _:genid124266 . [] oboInOwl:hasDbXref "GO:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000511 ; owl:annotatedTarget "A peptide hormone secreting cell that secretes androgen binding protein." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget _:genid124271 . [] oboInOwl:hasDbXref "NLM:thymus", "Wikipedia:Thymus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010548" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget "Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000253" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.558", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget "A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Thymus_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002370 ; owl:annotatedTarget "UMLS:C0040113" . [] oboInOwl:hasDbXref "IUBMB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "2-aminoethyl sulfonate" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget _:genid124283 . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "The soft tissue that fills the cavities of bones." . _:genid123405 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001218" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002315 . [] oboInOwl:source "ncithesaurus:Bone_Marrow" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "UMLS:C0005953" . [] oboInOwl:hasDbXref "BTO:0000141", "FMA:9608" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "medulla ossea" . [] oboInOwl:hasDbXref "BTO:0000141", "Wikipedia:Bone_marrow" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "medulla ossium" . [] oboInOwl:hasDbXref "BTO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002371 ; owl:annotatedTarget "medulla of bone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget obo:UBERON_0001961 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget _:genid124294 . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002380" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget "Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx." . [] oboInOwl:source "ncithesaurus:Tonsil" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget "UMLS:C0836921" . [] oboInOwl:source "ncithesaurus:Tonsilar_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget "UMLS:C1519547" . [] oboInOwl:source "ncithesaurus:Tonsillar_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget "UMLS:C1519548" . [] oboInOwl:hasDbXref "BTO:0001387" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002372 ; owl:annotatedTarget "Mandel" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002374 ; owl:annotatedTarget obo:UBERON_0003821 . _:genid123427 oboInOwl:hasDbXref "Wikipedia:Metacarpal_bone", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002374 ; owl:annotatedTarget "A bone that is part of the metacarpal skeleton." ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002318 . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002374 ; owl:annotatedTarget "UMLS:C0025526" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget obo:UBERON_0001739 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget _:genid124314 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget _:genid124316 . [] oboInOwl:hasDbXref "AAO:LAP", "FEED:rd", "https://github.com/obophenotype/uberon/issues/257" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "A cartilaginous ring that provides support for the arytenoid cartilages and forms the caudal part of the larynx." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000675" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "Cartilaginous ring that provides support for the arytenoid cartilages. Its ventral part is bent posteriorly to form a V.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001308" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/cricoid+cartilage" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "The ringlike cartilage forming the caudal part of the larynx. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001308" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.239-241", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]" . _:genid123436 oboInOwl:source "ncithesaurus:Cricoid_Cartilage" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "UMLS:C0010323" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000369 . [] oboInOwl:hasDbXref "Wikipedia:Cricoid_cartilage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cartilago cricoidea" . _:genid123438 oboInOwl:hasDbXref "Wikipedia:Cricoid_cartilage" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cartilaginis cricoideae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005403 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cartilago cricoidea" . [] oboInOwl:hasDbXref "AAO:0000675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cartilago cricotrachealis" . [] oboInOwl:hasDbXref "Wikipedia:Cricoid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cricoid" . [] oboInOwl:hasDbXref "Wikipedia:Cricoid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "cricoidea" . [] oboInOwl:hasDbXref "VHOG:0001308" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "innominate cartilage" . [] oboInOwl:hasDbXref "Wikipedia:Cricoid_cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002375 ; owl:annotatedTarget "krykoid cartilage" . ( ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget _:genid124337 . _:genid123452 oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget _:genid124339 ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001893 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "Any skeletal muscle that is part of the head region." . [] oboInOwl:hasDbXref "ZFA:0001652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "cephalic muscle" . [] oboInOwl:hasDbXref "MA:0000578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "head muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "head muscle organ" . [] oboInOwl:hasDbXref "FMA:9616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "muscle of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "muscle organ of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "muscle organ of head" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000513 ; owl:annotatedTarget obo:CL_0000056 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "adult head muscle organ" . [] oboInOwl:hasDbXref "ZFA:0001652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002376 ; owl:annotatedTarget "cranial muscle" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget _:genid124354 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "Any muscle that is part of the cervical (neck) region." . [] oboInOwl:source "ncithesaurus:Neck_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "UMLS:C0027532" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "muscle organ of neck" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000513 ; owl:annotatedTarget "A precursor cell destined to differentiate into cardiac muscle cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "muscle organ of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "neck (volume) muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002377 ; owl:annotatedTarget "neck muscle organ" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget _:genid124366 . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." . [] oboInOwl:source "ncithesaurus:Abdominal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget "UMLS:C0000739" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget "abdomen muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget "muscle organ of abdomen" . [] oboInOwl:hasDbXref "EMAPA:35103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002378 ; owl:annotatedTarget "abdominal wall musculature" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget _:genid124378 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "Any muscle organ that is part of a perineum [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Perineal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "UMLS:C0224382" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "muscle organ of perineal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "muscle organ of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "perineal region muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002379 ; owl:annotatedTarget "perineum muscle organ" . [] oboInOwl:notes "external occipital protuberance nuchal ligament medial superior nuchal line spinous processes of vertebrae C7-T12" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124387 . [] oboInOwl:notes "external occipital protuberance nuchal ligament medial superior nuchal line spinous processes of vertebrae C7-T12" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124389 . [] oboInOwl:notes "posterior border of the lateral third of the clavicle acromion process and spine of scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124391 . [] oboInOwl:notes "posterior border of the lateral third of the clavicle acromion process and spine of scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124393 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "Aminoethylsulfonic acid" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124395 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget _:genid124397 . [] oboInOwl:hasDbXref "Wikipedia:Trapezius_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget "A large superficial muscle that extends longitudinally from the occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula (shoulder blade). Its functions are to move the scapulae and support the arm. The trapezius has three functional regions: the superior region (descending part), which supports the weight of the arm; the intermediate region (transverse part), which retracts the scapulae; and the inferior region (ascending part), which medially rotates and depresses the scapulae. [WP,unvetted]." . _:genid123503 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000834" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.345", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget "The sternomastoid and the three parts of the trapezius are branchiomeric muscles that have secondarily acquired an attachment to the pectoral girdle. They evolved from the fish cucullaris.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003098 . [] oboInOwl:source "ncithesaurus:Trapezius_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget "UMLS:C0224361" . _:genid123505 oboInOwl:hasDbXref "Wikipedia:Trapezius_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget "musculus trapezius" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005492 . [] oboInOwl:hasDbXref "Wikipedia:Trapezius_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002380 ; owl:annotatedTarget "spinotrapezius" . _:genid123507 a owl:Restriction ; owl:onProperty obo:BSPO_0000108, obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001100, obo:UBERON_0005412 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget obo:UBERON_0001495 . _:genid123509 oboInOwl:notes "lateral pectoral nerve and medial pectoral nerveClavicular head: C5 and C6Sternocostal head: C7 C8 and T1" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget _:genid124406 ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0005606 . [] oboInOwl:notes "anterior surface of the sternum and the superior six costal cartilages and the aponeurosis of the external oblique muscle" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget _:genid124408 . [] oboInOwl:notes "anterior surface of the medial half of the clavicle" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget _:genid124410 . [] oboInOwl:notes "Lateral lip of intertubercular groove of the humerus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget _:genid124412 . _:genid123513 oboInOwl:hasDbXref "Wikipedia:Pectoralis_major_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget "The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001619 . [] oboInOwl:source "ncithesaurus:Pectoralis_Major" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget "UMLS:C0585574" . [] oboInOwl:hasDbXref "Wikipedia:Pectoralis_major_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002381 ; owl:annotatedTarget "musculus pectoralis major" . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget _:genid124417 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget _:genid124419 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget obo:CL_0000056 . [] oboInOwl:hasDbXref "Wikipedia:Rectus_abdominis_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget "The rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall of the abdomen. There are two parallel sets of muscles, separated by a midline band of connective tissue called the linea alba (white line). It extends from the pubic symphysis/pubic crest inferiorly to the xiphisternum/xiphoid process and lower costal cartilages (5-7) superiorly. It is contained in the Rectus sheath. The rectus is usually crossed by three fibrous bands licked by the tendinous inscriptions. [WP,modified]." . [] oboInOwl:source "ncithesaurus:Rectus_Abdominis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget "UMLS:C0206066" . [] oboInOwl:hasDbXref "AAO:0010789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget "m. rectus abdominis" . [] oboInOwl:hasDbXref "AAO:0010789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget "musculus rectus abdominis" . [] oboInOwl:hasDbXref "MA:0002364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002382 ; owl:annotatedTarget "rectus abdominis" . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000017", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/23" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000098" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001641" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000017" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D032390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "A precursor cell destined to differentiate into smooth muscle myocytes." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "MA also has set of connective tissues" . [] oboInOwl:source "ncithesaurus:Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "UMLS:C0009780" . [] oboInOwl:hasDbXref "FMA:9640" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "portion of connective tissue" . [] oboInOwl:hasDbXref "BTO:0000421" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002384 ; owl:annotatedTarget "Bindegewebe" . [] oboInOwl:hasDbXref "MESH:D032390" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000514 ; owl:annotatedTarget "myoblast, smooth muscle" . _:genid123541 oboInOwl:hasDbXref "GO:0060537", "Wikipedia:Muscle_tissue", "https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002385 ; owl:annotatedTarget "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0009676 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000306" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002385 ; owl:annotatedTarget "One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]" . [] oboInOwl:source "ncithesaurus:Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002385 ; owl:annotatedTarget "UMLS:C2328219" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002385 ; owl:annotatedTarget "muscular tissue" . [] oboInOwl:hasDbXref "FMA:9641" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002385 ; owl:annotatedTarget "portion of muscle tissue" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget _:genid124453 . [] oboInOwl:hasDbXref "PHENOSCAPE:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000341" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "The middle forelimb region. [Evolution, Fourth_Edition_(2006)_Boston_etc.:_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.321, see_Kardong_KV][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000341" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Forearm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "UMLS:C0016536" . _:genid123556 oboInOwl:hasDbXref "VSAO:0005058", "Wikipedia:Forearm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "antebrachium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006284 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "arm middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "arm zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "brachial region middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "brachial region zeugopod" . [] oboInOwl:hasDbXref "MA:0000034" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "lower arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "middle limb segment of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "middle limb segment of brachial region" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "middle limb segment of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "middle limb segment of proximal segment of free upper limb" . [] oboInOwl:hasDbXref "FMA:9663", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "regio antebrachialis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "zeugopod of brachial region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "zeugopod of proximal segment of free upper limb" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "wing zeugopod" . [] oboInOwl:hasDbXref "Wikipedia:Forearm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002386 ; owl:annotatedTarget "antebrachium" . [] oboInOwl:hasDbXref "Wikipedia:Foot", "Wikipedia:Pes_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "Distal portion of the hind limb, including tarsal region, metatarsal region and digits." . _:genid123578 oboInOwl:source "ncithesaurus:Foot" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "UMLS:C0016504" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013148 . [] oboInOwl:hasDbXref "MA:0000044" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hindlimb autopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hindlimb autopodium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hindlimb distal free limb segment" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "pes" . [] oboInOwl:hasDbXref "EMAPA:17428", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hind paw" . [] oboInOwl:hasDbXref "EMAPA:17428" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hind-paw" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hindfeet" . [] oboInOwl:hasDbXref "MA:0000044" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hindpaw" . [] oboInOwl:hasDbXref "VHOG:0000350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002387 ; owl:annotatedTarget "hind limb autopodium" . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget _:genid124498 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "A digit that is part of a manus (hand)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000857" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "One of the fingers of the manus.[AAO]" . [] oboInOwl:source "ncithesaurus:Finger" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "UMLS:C0016129" . [] oboInOwl:hasDbXref "FMA:9666" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "digit of hand" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15891 ; owl:annotatedTarget "beta-aminoethylsulfonic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000515 ; owl:annotatedTarget obo:CL_0000056 . [] oboInOwl:hasDbXref "FMA:9666" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "finger" . [] oboInOwl:hasDbXref "AAO:0000857", "XAO:0003036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "fore digit" . [] oboInOwl:hasDbXref "MA:0000041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "hand digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002389 ; owl:annotatedTarget "manual digit (phalangeal portion) plus soft tissue" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget _:genid124509 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget _:genid124511 . [] oboInOwl:hasDbXref "Wikipedia:Haematopoiesis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "Anatomical system that is involved in the production of hematopoietic cells." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011002" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "Anatomical system that consists of the blood and blood forming tissues.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001624" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.coph.2010.05.004 Ellett F, Lieschke GJ, Zebrafish as a model for vertebrate hematopoiesis. Current Opinion in Pharmacology (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000515 ; owl:annotatedTarget "A myoblast that differentiates into skeletal muscle fibers." . _:genid123610 oboInOwl:source "ncithesaurus:Hematopoietic_System" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "UMLS:C0018957" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002240 . [] oboInOwl:hasDbXref "BTO:0000570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002390 ; owl:annotatedTarget "Blutbildungssystem" . _:genid123612 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005281, obo:UBERON_0006558 . [] oboInOwl:hasDbXref "Wikipedia:Lymph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002391 ; owl:annotatedTarget "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." . [] oboInOwl:source "ncithesaurus:Lymph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002391 ; owl:annotatedTarget "UMLS:C0024202" . [] oboInOwl:hasDbXref "Wikipedia:Lymph" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002391 ; owl:annotatedTarget "lympha" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0008969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000664" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.256", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "The nasolacrimal duct is probably homologous to the posterior (excurrent) naris of actinopterygian fishes.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "nasolacrimal duct - posterior naris" . [] oboInOwl:source "ncithesaurus:Nasolacrimal_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "UMLS:C0027437" . [] oboInOwl:hasDbXref "Wikipedia:Nasolacrimal_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "d. nasolacrimalis" . [] oboInOwl:hasDbXref "Wikipedia:Nasolacrimal_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002392 ; owl:annotatedTarget "tear duct" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget obo:UBERON_0000062 . [] oboInOwl:source "UBERON:0010062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget _:genid124541 . [] oboInOwl:hasDbXref "FMA:FMA", "Wikipedia:Eustachian_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "Organ with organ cavity which connects the cavity of the middle ear to the cavity of the pharynx. Examples: There are only two pharyngotympanic tubes, the right and the left pharyngotympanic tubes.[FMA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000146" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "Furrow on the ventral surface of the otic capsule, and occasionally also the parasphenoid, that houses the Eustachian tube.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001145" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/auditory+tube" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "The narrow channel connecting the nasopharynx and the middle ear. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000146" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001145" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[uncertain][VHOG]" . [] oboInOwl:source "ncithesaurus:Eustachian_Tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "UMLS:C0015183" . [] oboInOwl:hasDbXref "MA:0000255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "auditory tube" . [] oboInOwl:hasDbXref "MA:0000255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "pharyngo-tympanic tube" . [] oboInOwl:hasDbXref "FMA:9705", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "tuba auditiva" . [] oboInOwl:hasDbXref "FMA:9705", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "tuba auditoria" . [] oboInOwl:hasDbXref "Wikipedia:Eustachian_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "tuba auditiva; tuba auditoria; tuba auditivea" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002393 ; owl:annotatedTarget "tuba pharyngotympanica" . _:genid123651 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001173, obo:UBERON_0009664 . [] oboInOwl:source "EMAPA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget _:genid124559 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget _:genid124561 . [] oboInOwl:hasDbXref "Wikipedia:Bile_duct", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." . [] oboInOwl:source "ZFA:0001100, ZFA:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "A duct that carries bile from the liver to the intestine." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000212" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/bile+duct" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000212" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "we place the ZFA class here as this fits its textual definition and child nodes. We may recommend a label change for ZFA" . [] oboInOwl:source "ncithesaurus:Bile_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "UMLS:C0005400" . [] oboInOwl:hasDbXref "FMA:9706" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "biliary duct" . [] oboInOwl:hasDbXref "BTO:0000122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "gall duct" . [] oboInOwl:hasDbXref "ZFA:0001100" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002394 ; owl:annotatedTarget "hepatic duct" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000525 ; owl:annotatedTarget "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." . [] oboInOwl:hasDbXref "Wikipedia:Talus_bone", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "A proximal tarsal bone resulting from fusion of intermedium and fibulare." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "The talus is apparently derived from the fusion of three separate bones in the feet of primitive amphibians; the tibiale, articulating with tibia, the intermedium, between the bases of the tibia and fibula, and the fourth centrale, lying in the mid-part of the tarsus. These bones are still partially separate in modern amphibians, which therefore do not have a true talus. The talus forms a considerably more flexible joint in mammals than it does in reptiles. This reaches its greatest extent in artiodactyls, where the distal surface of the bone has a smooth keel to allow greater freedom of movement of the foot, and thus increase running speed" . [] oboInOwl:source "ncithesaurus:Talus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "UMLS:C0039277" . [] oboInOwl:hasDbXref "BTO:0002354" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "astragaloid bone" . [] oboInOwl:hasDbXref "ISBN:0073040584", "MA:000135", "Wikipedia:Talus_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "astragalus" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Talus_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "astragalus bone" . [] oboInOwl:hasDbXref "BTO:0002354" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "os tarsi tibiale" . [] oboInOwl:hasDbXref "Wikipedia:Talus_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002395 ; owl:annotatedTarget "os trigonum" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D009475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000526 ; owl:annotatedTarget "A neuron which conveys sensory information centrally from the periphery." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:notes "palatal series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget _:genid124592 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "The triangular flat bone of the nasal septum." . _:genid123685 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000308" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006524 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000633" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000308" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000308" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "relationship loss: overlaps mesethmoid-vomer joint (TAO:0001680)[TAO]" . [] oboInOwl:source "Wikipedia:Vomer#In_other_animals" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "In bony fish, the vomers are flattened, paired, bones forming the anterior part of the roof of the mouth, just behind the premaxillary bones. In many species, they have teeth, supplementing those in the jaw proper; in some extinct species the teeth on the vomers were actually larger than the primary set. In amphibians and reptiles, the vomers become narrower, due to the presence of the enlarged choanae (the inner part of the nostrils) on either side, and they may extend further back in the jaw. They are typically small in birds, where they form the upper hind part of the beak, again being located between the choanae. In mammals, the vomers have become narrower still, and are fused into a single, vertically oriented bone. The development of the hard palate beneath the vomer means that the bone is now located in a nasal chamber, separate from the mouth[WP]" . [] oboInOwl:hasDbXref "MESH:D009476" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000527 ; owl:annotatedTarget "A neuron which sends impulses peripherally to activate muscles or secretory cells." . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000308" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "The vomer is paired in some taxa (e.g., Amia) while unpaired in others (e.g., teleosts).[TAO]" . [] oboInOwl:source "ncithesaurus:Vomer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "UMLS:C0242403" . [] oboInOwl:hasDbXref "TAO:0000308" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002396 ; owl:annotatedTarget "prevomer" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget obo:UBERON_0008193 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget obo:UBERON_0008907 . [] oboInOwl:notes "facial series" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget _:genid124606 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget _:genid124608 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget _:genid124610 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget _:genid124613 . [] oboInOwl:hasDbXref "Wikipedia:Maxilla", "http://palaeos.com/vertebrates/glossary/glossaryM.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "The bone which normally forms the lateral upper jaw in osteichthyans, including tetrapods." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000270" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:GA_TG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "Dermal bone that forms part of the upper jaw, located antero-ventral to the premaxilla. The maxilla is a paired bone.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000285" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "Paired, intramembranous bone located on the lateral sides of the skull, posterior to the premaxillae.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000270" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "relationship loss: overlaps autopalatine-maxillary joint (TAO:0001942)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000270" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "relationship loss: overlaps premaxillary-maxillary joint (TAO:0002260)[TAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000270" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "In some teleosts, the maxilla is located postero-ventral to the supramaxilla. Commonly, the articular process of the maxilla articulates with the autopalatine and ethmoidal region antero-medially. The maxilla is usually the largest bone in the upper jaw assemblage.[TAO]" . [] oboInOwl:source "ncithesaurus:Maxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "UMLS:C0024947" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "maxillae" . [] oboInOwl:hasDbXref "MESH:D009474", "http://en.wikipedia.org/wiki/Neuron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000540 ; owl:annotatedTarget "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." . [] oboInOwl:hasDbXref "Wikipedia:Maxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002397 ; owl:annotatedTarget "maxillary bone" . [] oboInOwl:hasDbXref "Wikipedia:Hand", "Wikipedia:Manus_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "Distal segment of the fore limb, including carpal region, metacarpal region and digits." . [] oboInOwl:source "ncithesaurus:Hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "UMLS:C0018563" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "forelimb autopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "forelimb autopodium" . [] oboInOwl:hasDbXref "MA:0000037" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "hand" . [] oboInOwl:hasDbXref "EHDAA2:0000728" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "hand region" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "fore foot" . [] oboInOwl:hasDbXref "EMAPA:17428", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "fore paw" . [] oboInOwl:hasDbXref "EMAPA:17428" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "fore-paw" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "forefeet" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "forefoot" . [] oboInOwl:hasDbXref "MA:0000037" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002398 ; owl:annotatedTarget "forepaw" . [] oboInOwl:hasDbXref "GOC:tfm", "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000541 ; owl:annotatedTarget "A cell that originates from the neural crest and differentiates into a pigment cell." . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002400 ; owl:annotatedTarget "The outer serous membrane of the pulmonary pleural." . [] oboInOwl:source "ncithesaurus:Parietal_Pleura" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002400 ; owl:annotatedTarget "UMLS:C0225777" . [] oboInOwl:hasDbXref "Wikipedia:Parietal_pleura" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002400 ; owl:annotatedTarget "pleura parietalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget _:genid124661 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." . [] oboInOwl:source "Wikipedia:Visceral_pleura" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "FMA treats this as part of the lungs" . [] oboInOwl:source "ncithesaurus:Visceral_Pleura" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "UMLS:C0225776" . [] oboInOwl:hasDbXref "FMA:9734", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "pleura pulmonalis" . [] oboInOwl:hasDbXref "Wikipedia:Visceral_pleura" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "pleura visceralis" . [] oboInOwl:hasDbXref "EHDAA2:0002205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "lung mesothelium" . [] oboInOwl:hasDbXref "FMA:9734" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002401 ; owl:annotatedTarget "pulmonary pleura" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget _:genid124677 . [] oboInOwl:hasDbXref "Wikipedia:Pleural_cavity", "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "The fluid-filled cavity that lies between the visceral and parietal pleurae." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000581" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86" . [] oboInOwl:source "ncithesaurus:Pleural_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "UMLS:C0178802" . _:genid123768 oboInOwl:hasDbXref "Wikipedia:Pleural_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "cavitas pleuralis" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0002037 . [] oboInOwl:hasDbXref "Wikipedia:Pleural_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "cavitum pleuralae" . [] oboInOwl:hasDbXref "Wikipedia:Pleural_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002402 ; owl:annotatedTarget "cavitum pleurale" . [] oboInOwl:hasDbXref "Wikipedia:Immune_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002405 ; owl:annotatedTarget "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001247" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:21046016 Dzik JM, The ancestry and cumulative evolution of immune reactions. Acta biochimica Polonica (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002405 ; owl:annotatedTarget "The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Immune_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002405 ; owl:annotatedTarget "UMLS:C0020962" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002406 ; owl:annotatedTarget _:genid124702 . [] oboInOwl:hasDbXref "Wikipedia:Pericardium", "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002406 ; owl:annotatedTarget "A double-walled sac containing the heart and the roots of the great vessels." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget _:genid124705 . [] oboInOwl:hasDbXref "Wikipedia:Pericardium", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010817" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:JMG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "Peritoneum that surrounds the heart.[AAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO)" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium" . [] oboInOwl:source "ncithesaurus:Pericardium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002407 ; owl:annotatedTarget "UMLS:C0031050" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002408 ; owl:annotatedTarget "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." . [] oboInOwl:source "ncithesaurus:Parietal_Pericardium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002408 ; owl:annotatedTarget "UMLS:C0225969" . [] oboInOwl:hasDbXref "FMA:9870", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002408 ; owl:annotatedTarget "lamina parietalis pericardii" . _:genid123804 oboInOwl:hasDbXref "VHOG:0000537" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002408 ; owl:annotatedTarget "parietal pericardium" ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0003886 . [] oboInOwl:hasDbXref "DOI:10.5962/bhl.title.1013" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002408 ; owl:annotatedTarget "pericardial sac" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002409 ; owl:annotatedTarget obo:UBERON_0007794 . [] oboInOwl:hasDbXref "FMA:9887", "Wikipedia:Pericardial_fluid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002409 ; owl:annotatedTarget "Transudate contained in the pericardial cavity.[FMA]." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "EMAPA", "MA", "NIFSTD", "ZFA-modified-from-isa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget _:genid124733 . [] oboInOwl:hasDbXref "GO:0048483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000396" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000033" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000396" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib" . [] oboInOwl:source "BIRNLEX:1123", "ncithesaurus:Autonomic_Nervous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "UMLS:C0004388" . [] oboInOwl:source "BIRNLEX:1123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "UMLS:C1305381" . [] oboInOwl:hasDbXref "FMA:65553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "autonomic division of peripheral nervous system" . _:genid123824 oboInOwl:hasDbXref "FMA:65553" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "autonomic part of peripheral nervous system" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004469 . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "divisio autonomica systematis nervosi peripherici" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "pars autonomica systematis nervosi peripherici" . [] oboInOwl:hasDbXref "FMA:65553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "peripheral autonomic nervous system" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "ANS" . [] oboInOwl:hasDbXref "Wikipedia:Autonomic_nervous_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002410 ; owl:annotatedTarget "divisio autonomica systematis nervosi peripherici" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002411 ; owl:annotatedTarget obo:UBERON_0000062 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002411 ; owl:annotatedTarget _:genid124751 . [] oboInOwl:source "EHDAA2", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002411 ; owl:annotatedTarget _:genid124753 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0003127" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002411 ; owl:annotatedTarget "The small, erectile body located at the anterior end of the vulva." . [] oboInOwl:source "ncithesaurus:Clitoris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002411 ; owl:annotatedTarget "UMLS:C0008984" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget obo:NCBITaxon_7901 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001189" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget "Endochondral bone that forms around the notochord and is part of the vertebral column.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000691" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_and_Maglia_2008" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget "Main component of the vertebral column. It consists of two essential parts, a dorsal neural arch and a ventral centrum.[AAO]" . [] oboInOwl:source "ncithesaurus:Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget "UMLS:C0549207" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002412 ; owl:annotatedTarget "vertebrae" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000542 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002413 ; owl:annotatedTarget obo:UBERON_0004451 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002413 ; owl:annotatedTarget "A vertebra that is located in the cervical region of the vertebral column." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002413 ; owl:annotatedTarget "cervical vertebrae" . [] oboInOwl:hasDbXref "Wikipedia:Cervical_vertebrae" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002413 ; owl:annotatedTarget "vertebrae cervicales" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0683073696", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000542 ; owl:annotatedTarget "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." . _:genid123861 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002481, obo:UBERON_0004880 . _:genid123863 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006267, obo:UBERON_0013509 . [] oboInOwl:hasDbXref "Wikipedia:Lumbar_vertebrae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002414 ; owl:annotatedTarget "Large vertebra of the movable part of the vertebral column, characterized by the absence of the foramen transversarium within the transverse process, and by the absence of facets on the sides of the body." . [] oboInOwl:source "PMCID:PMC2700063" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002414 ; owl:annotatedTarget "Whereas all rats had six lumbar vertebrae, variable patterns in mice included mostly five vertebrae in DBA/2J, mostly six vertebrae in C57BL/6J, and a mix in B6129PF2/J" . [] oboInOwl:source "ncithesaurus:Lumbar_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002414 ; owl:annotatedTarget "UMLS:C0024091" . [] oboInOwl:hasDbXref "AEO:0000109", "Wikipedia:Tail" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002415 ; owl:annotatedTarget "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002415 ; owl:annotatedTarget "caudal subdivision" . [] oboInOwl:hasDbXref "CARO:0002001", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/29" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000403" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "(...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Integumentary_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "UMLS:C0037267" . _:genid123877 oboInOwl:hasDbXref "FMA:72979" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "integumentary system" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003059 . [] oboInOwl:hasDbXref "MIAA:0000033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "dermal system" . [] oboInOwl:hasDbXref "Wikipedia:Integumentary_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "integumentum commune" . [] oboInOwl:hasDbXref "EHDAA2:0003154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "organism surface" . [] oboInOwl:hasDbXref "BILA:0000118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002416 ; owl:annotatedTarget "surface" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget obo:UBERON_0009569 . [] oboInOwl:hasDbXref "Wikipedia:Lumbar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget "The abdominal segment of the torso." . [] oboInOwl:hasDbXref "MA:0000021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget "abdomen/pelvis/perineum" . [] oboInOwl:hasDbXref "MA:0000021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget "lower body" . [] oboInOwl:hasDbXref "FMA:259211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget "lower trunk" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002417 ; owl:annotatedTarget "lumbar region" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/117" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget obo:UBERON_0002481 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000040", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/37", "https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000060" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001501" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000040" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000060" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001207" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1525-142X.2011.00520.x Hall BK, Parallelism, deep homology, and evo-devo. Evolution and Development (2012)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "UMLS:C0007301" . [] oboInOwl:hasDbXref "FMA:37377" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "cartilage tissue" . [] oboInOwl:hasDbXref "VSAO:0000040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "chondrogenic tissue" . [] oboInOwl:hasDbXref "VHOG:0001207" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "cartilages" . [] oboInOwl:hasDbXref "FMA:37377" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002418 ; owl:annotatedTarget "portion of cartilage tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002419 ; owl:annotatedTarget "A gland that is part of a skin of body [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71878", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002419 ; owl:annotatedTarget "glandulae cutis" . [] oboInOwl:hasDbXref "FMA:71878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002419 ; owl:annotatedTarget "set of skin glands" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002419 ; owl:annotatedTarget "skin glands" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002419 ; owl:annotatedTarget "skin glands set" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002420 ; owl:annotatedTarget obo:UBERON_0007245 . [] oboInOwl:hasDbXref "BIRNLEX:826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002420 ; owl:annotatedTarget "An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002420 ; owl:annotatedTarget "basal ganglia" . [] oboInOwl:hasDbXref "MA:0000184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002420 ; owl:annotatedTarget "basal nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Basal_ganglia" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002420 ; owl:annotatedTarget "nuclei basales" . [] oboInOwl:source "GO", "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget _:genid124841 . [] oboInOwl:source "MBA-indirect", "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget _:genid124843 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment]." . [] oboInOwl:source "NIF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum" . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget obo:UBERON_0002264 . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "BTO:0000601 is placed here since it includes the DG. GO also includes dentate gyrus development as part of hippocampus development, so we assume when GO says 'hippocampus' it means 'hippocampal formation'. In ABA HPF = (.. subiculum) + HIP, HIP = DG + AH." . [] oboInOwl:source "BIRNLEX:715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "UMLS:C0175202" . [] oboInOwl:source "BIRNLEX:715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "neuronames:177" . [] oboInOwl:hasDbXref "BTO:0000601", "GO:0021766" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "hippocampus" . [] oboInOwl:hasDbXref "MA:0000189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "archipallium" . [] oboInOwl:hasDbXref "NeuroNames:177" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "formatio hippocampi" . [] oboInOwl:hasDbXref "BTO:0000601" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "major hippocampus" . [] oboInOwl:hasDbXref "MA:0000189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "primal cortex" . [] oboInOwl:hasDbXref "NeuroNames:177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002421 ; owl:annotatedTarget "seahorse" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget _:genid124861 . [] oboInOwl:hasDbXref "BIRNLEX:1256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000110" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011043" ; oboInOwl:ontology "AAO" ; oboInOwl:source "UBERON:0002422" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "Irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.[AAO]" . [] oboInOwl:source "GO:0021592" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space[GO][GO:0021592]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000006" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Fourth_Ventricle_of_the_Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "UMLS:C0149556" . [] oboInOwl:hasDbXref "ZFA:0000110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "ventricle IV" . [] oboInOwl:hasDbXref "ZFA:0000110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "rhombencephalic vesicle" . _:genid123947 oboInOwl:hasDbXref "MA:0000196" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "4th ventricle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000410 . [] oboInOwl:hasDbXref "VHOG:0000006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "IVth ventricle" . [] oboInOwl:hasDbXref "BAMS:V4" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "fourth ventricle proper" . [] oboInOwl:hasDbXref "VHOG:0000006" ; oboInOwl:hasSynonymType core:NON_MAMMAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "hindbrain ventricle" . [] oboInOwl:hasDbXref "VHOG:0000006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "rhombencephalic ventricle" . [] oboInOwl:hasDbXref "BTO:0003426" ; oboInOwl:hasSynonymType core:NON_MAMMAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "ventricle of hindbrain" . [] oboInOwl:hasDbXref "BTO:0003426" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "ventricle of rhombencephalon" . [] oboInOwl:hasDbXref "Wikipedia:Fourth_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002422 ; owl:annotatedTarget "ventriculus quartus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002423 ; owl:annotatedTarget "The part of the digestive system that contains the liver and the biliary system." . [] oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002423 ; owl:annotatedTarget "System responsible for the production and movement of bile[ZFIN:curator]." . [] oboInOwl:source "ncithesaurus:Hepatobiliary_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002423 ; owl:annotatedTarget "UMLS:C1711359" . [] oboInOwl:hasDbXref "GO:0061008" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002423 ; owl:annotatedTarget "hepaticobiliary system" . [] oboInOwl:source "AAO-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget _:genid124893 . _:genid123969 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002346 . [] oboInOwl:source "ZFA:0000816" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]." . _:genid123971 oboInOwl:source "PMID:16488870" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003075 . [] oboInOwl:source "ncithesaurus:Oral_Cavity_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "UMLS:C1709332" . _:genid123973 oboInOwl:hasDbXref "FMA:265152" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "epithelium of mucosa of mouth" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005062 . [] oboInOwl:hasDbXref "FMA:265152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002424 ; owl:annotatedTarget "epithelium of oral mucosa" . _:genid123975 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0022350 _:genid123977 ) ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000333 . _:genid123977 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000110, obo:UBERON_0002357 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget _:genid124905 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget _:genid124907 . [] oboInOwl:hasDbXref "Wikipedia:Visceral_pericardium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." . [] oboInOwl:hasDbXref "Wikipedia:Epicardium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget "lamina visceralis pericardii serosi" . [] oboInOwl:hasDbXref "VHOG:0000538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget "visceral pericardium" . [] oboInOwl:hasDbXref "MA:0000484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget "epicardium" . [] oboInOwl:hasDbXref "EMAPA:16589" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002425 ; owl:annotatedTarget "pericardium visceral mesothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "Any muscle organ that is part of a chest [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "anterior thoracic region muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "anterolateral part of thorax muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "chest muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "front of thorax muscle organ" . [] oboInOwl:hasDbXref "FMA:9619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "muscle of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "muscle organ of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "muscle organ of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "muscle organ of chest" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "Beilstein:1281607" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002426 ; owl:annotatedTarget "muscle organ of front of thorax" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002427 ; owl:annotatedTarget "A zone of skin that is part of an arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002427 ; owl:annotatedTarget "EMAPA:37350" . [] oboInOwl:source "ncithesaurus:Arm_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002427 ; owl:annotatedTarget "UMLS:C0222204" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002427 ; owl:annotatedTarget "skin of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002427 ; owl:annotatedTarget "brachial region skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002428 ; owl:annotatedTarget "A bone that is part of a limb [Automatically generated definition]." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002428 ; owl:annotatedTarget "NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle" . [] oboInOwl:source "ncithesaurus:Bone_of_the_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002428 ; owl:annotatedTarget "UMLS:C0582791" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002428 ; owl:annotatedTarget "bone of limb" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002428 ; owl:annotatedTarget "free limb bone" . _:genid124021 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000029 _:genid124023 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 . _:genid124023 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000974, obo:UBERON_0002425 . [] oboInOwl:hasDbXref "Wikipedia:Cervical_lymph_node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002429 ; owl:annotatedTarget "Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted]." . _:genid124026 oboInOwl:source "ncithesaurus:Cervical_Lymph_Node" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002429 ; owl:annotatedTarget "UMLS:C0588054" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002349 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget _:genid124955 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget _:genid124957 . [] oboInOwl:source "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget _:genid124959 . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget _:genid124961 . [] oboInOwl:hasDbXref "GOC:jl", "Wikipedia:Striatum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO]." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget obo:UBERON_0006514 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "FMA divides 'striatum of neuraxis' into 4, neostriatum is seperate class. In NIF these are synonyms. TODO - check striatum vs corpus striatum see Wikipedia:Striatum#History. Check caudoputamen" . [] oboInOwl:source "BIRNLEX:1672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "UMLS:C0162512" . [] oboInOwl:source "BIRNLEX:1672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "neuronames:225" . [] oboInOwl:hasDbXref "BIRNLEX:1672", "GO:0021756", "Wikipedia:Striatum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "neostriatum" . [] oboInOwl:hasDbXref "FMA:83683" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "neuraxis striatum" . [] oboInOwl:hasDbXref "GO:0021756", "Wikipedia:Striatum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "striate nucleus" . [] oboInOwl:hasDbXref "BIRNLEX:1672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "striatum" . [] oboInOwl:hasDbXref "FMA:83683" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "striatum of neuraxis" . [] oboInOwl:hasDbXref "BIRNLEX:1672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "caudate putamen" . [] oboInOwl:hasDbXref "MA:0000891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "corpus striatum" . [] oboInOwl:hasDbXref "NeuroNames:225" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "corpus striatum (Zilles)" . [] oboInOwl:hasDbXref "BIRNLEX:1672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "dorsal striatum" . [] oboInOwl:hasDbXref "BTO:0000418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002435 ; owl:annotatedTarget "striated nucleus" . ( ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "White matter that is part of a cerebral hemisphere." . _:genid124052 oboInOwl:external_ontology "BTO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "The BTO class is inconsistent as it is part of the brain and spinal cord." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002068 . [] oboInOwl:source "BIRNLEX:711", "ncithesaurus:Cerebral_White_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "UMLS:C0152295" . _:genid124054 oboInOwl:source "BIRNLEX:711" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "UMLS:C1284115" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002073 . [] oboInOwl:source "BIRNLEX:711" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "neuronames:189" . _:genid124056 oboInOwl:hasDbXref "MA:0000945" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "cerebral white matter" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002074 . [] oboInOwl:hasDbXref "FMA:61822" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "white matter structure of cerebral hemisphere" . _:genid124058 oboInOwl:hasDbXref "FMA:256174" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "region of cerebral white matter" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000409 . [] oboInOwl:hasDbXref "NeuroNames:189" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002437 ; owl:annotatedTarget "substantia medullaris cerebri" . _:genid124060 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002464 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001493 ] ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000410 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002442 ; owl:annotatedTarget "EMAPA:37719" . [] oboInOwl:hasDbXref "FMA:65265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002442 ; owl:annotatedTarget "trunk of right axillary nerve" . [] oboInOwl:hasDbXref "MA:0001175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002442 ; owl:annotatedTarget "circumflex nerve trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "A blood vessel that is part of a choroid [Automatically generated definition]." . _:genid124073 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "blood vessel of choroid" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002350 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "blood vessel of choroid coat" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "blood vessel of choroidea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "blood vessel of posterior uvea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "choroid blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "choroid coat blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "choroidea blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "posterior uvea blood vessel" . [] oboInOwl:hasDbXref "FMA:76550", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "vasa sanguinea choroideae" . [] oboInOwl:hasDbXref "FMA:76550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002443 ; owl:annotatedTarget "set of choroid blood vessels" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/114" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "The postaxial bone of the proximal carpal region. Found in close approximation to the ulna, often in articulation[PHENOSCAPE:ad]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000845" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "One of two element that constitute the basal row of carpals. It articulates with the ulna, radius, radiale, centrale (element Y), and carpal 5(4). This element originates from one condensation center or the fusion of two elements (ulnare and intermedium). Occasionally it may fuse to carpal 5(4), the radiale, or other elements.[AAO]" . [] oboInOwl:source "ncithesaurus:Triangular_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "UMLS:C0223739" . [] oboInOwl:hasDbXref "FMA:23715", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "os triquetrum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "os ulnare" . [] oboInOwl:hasDbXref "MA:0001347", "NCBITaxon:9606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "triquetral" . [] oboInOwl:hasDbXref "MA:0001347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "cuneiform of hand" . [] oboInOwl:hasDbXref "MA:0001347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "triangular" . [] oboInOwl:hasDbXref "MA:0001347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "triquetrum" . [] oboInOwl:hasDbXref "MA:0001347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002445 ; owl:annotatedTarget "ulnar carpal bone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "CAS:492-61-5" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget obo:UBERON_0001479 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=3470151&group_id=76834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget "A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad]." . [] oboInOwl:source "ncithesaurus:Patella" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget "UMLS:C0030647" . [] oboInOwl:hasDbXref "FMA:24485" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget "knee bone" . [] oboInOwl:hasDbXref "Wikipedia:Patella" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget "knee cap" . [] oboInOwl:hasDbXref "Wikipedia:Patella" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002446 ; owl:annotatedTarget "patella" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:component "maternal" ; oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget _:genid125045 . [] oboInOwl:hasDbXref "MP:0004256", "PMID:11433360" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "The maternal uterine-derived portion of the placenta." . [] oboInOwl:source "ncithesaurus:Decidua" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "UMLS:C0011106" . [] oboInOwl:hasDbXref "FMA:85538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "decidous membrane" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "extraembryonic part of placenta" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "extraembryonic placenta" . [] oboInOwl:hasDbXref "MP:0004256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "maternal decidual layer" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "maternal part of placenta" . _:genid124123 oboInOwl:hasDbXref "EMAPA:35269", "GOC:dph" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "maternal placenta" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012469 . [] oboInOwl:hasDbXref "BTO:0001360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002450 ; owl:annotatedTarget "uterine decidua" . _:genid124129 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002406, obo:UBERON_0012276 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget obo:UBERON_0000414 . [] oboInOwl:source "Wikipedia:Tubular_gland" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget _:genid125064 . [] oboInOwl:hasDbXref "Wikipedia:Uterine_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget "The mucous secreting gland associated with the mucuous membrane lining the uterus." . _:genid124133 oboInOwl:source "ncithesaurus:Uterine_Gland" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget "UMLS:C1183035" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002359 . [] oboInOwl:hasDbXref "BTO:0003433" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget "endometrial gland" . [] oboInOwl:hasDbXref "FMA:71647", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget "glandulae uterinae" . [] oboInOwl:hasDbXref "Wikipedia:Uterine_glands" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002451 ; owl:annotatedTarget "glandulae uterinae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget obo:UBERON_0001825 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "The evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses." . [] oboInOwl:source "ncithesaurus:Ethmoid_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "UMLS:C0015028" . [] oboInOwl:hasDbXref "Wikipedia:Ethmoid_bone_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "ethmoidal bone sinus" . [] oboInOwl:hasDbXref "FMA:84115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "ethmoidal sinus" . _:genid124142 oboInOwl:hasDbXref "Wikipedia:Ethmoid_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "cellulae ethmoidales" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 . [] oboInOwl:hasDbXref "FMA:84115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002453 ; owl:annotatedTarget "ethmoidal air cell" . [] oboInOwl:hasDbXref "Wikipedia:Internal_thoracic_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "An artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "MA has both mammary and thoracic" . [] oboInOwl:source "ncithesaurus:Internal_Mammary_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "UMLS:C0226276" . [] oboInOwl:hasDbXref "MA:0001982" ; oboInOwl:hasSynonymType core:PENDING_REVIEW ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "internal mammary artery" . [] oboInOwl:hasDbXref "Wikipedia:Internal_thoracic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "arteria mammaria interna" . _:genid124152 oboInOwl:hasDbXref "Wikipedia:Internal_thoracic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "arteria thoracica interna" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002407 . [] oboInOwl:hasDbXref "EMAPA:18617" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002456 ; owl:annotatedTarget "mammary artery" . [] oboInOwl:hasDbXref "MP:0010662" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002457 ; owl:annotatedTarget "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." . _:genid124155 oboInOwl:source "ZFA:0001061" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002457 ; owl:annotatedTarget "Arteries that connect the dorsal aorta and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these vessels don't have venous or arteriproperty_value external_definitionmarkers. They form from the primary sprouts from the dorsal aorta[ZFA:0001061]." ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0006815 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000225" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.612", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002457 ; owl:annotatedTarget "Few changes of evolutionary significance occur in the branching pattern of the dorsal aorta. All vertebrates have (...) paired intersegmental arteries to the trunk, tail, and paired appendages.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002457 ; owl:annotatedTarget "intersegmental artery" . [] oboInOwl:hasDbXref "ZFA:0001061" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002457 ; owl:annotatedTarget "intersegmental arteries" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Spinal_artery", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002458 ; owl:annotatedTarget "Arteries that supply the spinal cord." . [] oboInOwl:source "ncithesaurus:Spinal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002458 ; owl:annotatedTarget "UMLS:C0447043" . [] oboInOwl:hasDbXref "ZFA:0000682" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002458 ; owl:annotatedTarget "spinal arteries" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002459 ; owl:annotatedTarget "A blood vessel that drains from from an lower eyelid." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002459 ; owl:annotatedTarget "EMAPA:37156" . [] oboInOwl:source "ncithesaurus:Inferior_Palpebral_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002459 ; owl:annotatedTarget "UMLS:C1760539" . [] oboInOwl:hasDbXref "MA:0002147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002459 ; owl:annotatedTarget "lower palpebral vein" . [] oboInOwl:hasDbXref "FMA:70847", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002459 ; owl:annotatedTarget "venae palpebrales inferiores" . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Vesical_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002460 ; owl:annotatedTarget "A tributary of the iliac vein that drains the urinary bladder." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002460 ; owl:annotatedTarget "EMAPA:37205" . _:genid124182 oboInOwl:hasDbXref "FMA:70911", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002460 ; owl:annotatedTarget "venae vesicales" ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0001773 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002460 ; owl:annotatedTarget "vesical veins" . (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget obo:UBERON_0002378 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget _:genid125123 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget "Any skeletal muscle organ that is part of a anterior abdominal wall. Examples: the obliques, pyramidalis and transversus abdominus." . [] oboInOwl:source "ncithesaurus:Anterior_Abdominal_Wall_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget "UMLS:C1744565" . [] oboInOwl:hasDbXref "FMA:20278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget "muscle of anterior abdominal wall" . _:genid124193 oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002461 ; owl:annotatedTarget "ventral abdominal wall muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 . [] oboInOwl:notes "sciatic nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget _:genid125130 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget _:genid125132 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget _:genid125134 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget _:genid125136 . _:genid124199 oboInOwl:hasDbXref "Wikipedia:Hamstring" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "Any of the posterior thigh muscles. [WP,modified]." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001691 . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "CAS:492-61-5" . [] oboInOwl:source "ncithesaurus:Hamstring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "UMLS:C0584895" . _:genid124201 oboInOwl:hasDbXref "MA:0002312" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "hamstring muscle" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009213 . [] oboInOwl:hasDbXref "FMA:22427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "muscle of posterior compartment of thigh" . _:genid124203 oboInOwl:hasDbXref "FMA:22427" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "posterior femoral muscle" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0004114 . [] oboInOwl:hasDbXref "VHOG:0000844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "hamstring" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_compartment_of_thigh" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "muscularis compartimentum femoris posterius" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_compartment_of_thigh" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "posterior fascial compartment of thigh" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_compartment_of_thigh" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "posterior femoral muscles" . [] oboInOwl:hasDbXref "FMA:81022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002463 ; owl:annotatedTarget "set of hamstring muscles" . [] oboInOwl:source "FMA:5913" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002464 ; owl:annotatedTarget "Segment of neural tree organ which consists of nerve fiber bundles aggregated to form a cable-like structure that branches off to different nerves; together with all nerves of the same tree. Example: trunk of cranial nerve, trunk of spinal nerve, trunk of peripheral nerve[FMA:5913]." . [] oboInOwl:hasDbXref "EMAPA:16986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002464 ; owl:annotatedTarget "peripheral nerve trunk" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget _:genid125155 . [] oboInOwl:hasDbXref "Wikipedia:Lymphoid_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010522" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000842" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" . [] oboInOwl:source "https://github.com/obophenotype/mouse-anatomy-ontology/issues/51" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "We follow FMA and MA in distinguishing between lymphatic system and lymphoid system, with lymhoid tissue part of the non-lymphatic component, although these terms are often used interchangeably. We assume the ZFA term lymphatic tissue actually corresponds to the broader class (e.g. ZFA lymph node in the ZFA lymphatic system). See tracker for more comments." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "EMAPA:37664" . [] oboInOwl:source "ncithesaurus:Lymphatic_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "UMLS:C0024235" . [] oboInOwl:hasDbXref "ZFA:0000385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "lymphatic system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "lymphatic circulatory system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "lymphatic drainage system" . [] oboInOwl:hasDbXref "Wikipedia:Lymphoid_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002465 ; owl:annotatedTarget "systema lymphoideum" . [] oboInOwl:hasDbXref "ISBN:0721601464", "MESH:A11.118.290.350.200", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." . [] oboInOwl:hasDbXref "Wikipedia:Succus_entericus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002466 ; owl:annotatedTarget "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." . [] oboInOwl:source "ncithesaurus:Intestinal_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002466 ; owl:annotatedTarget "UMLS:C0021849" . [] oboInOwl:hasDbXref "FMA:62974" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002466 ; owl:annotatedTarget "intestinal secretion" . [] oboInOwl:hasDbXref "Wikipedia:Succus_entericus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002466 ; owl:annotatedTarget "succus entericus" . [] oboInOwl:hasDbXref "BTO:0000644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002466 ; owl:annotatedTarget "intestinal juice" . _:genid124239 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000949, obo:UBERON_0001043 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000547 ; owl:annotatedTarget "rubriblast" . _:genid124241 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000926, obo:UBERON_0001096 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "A mucosa that is part of a esophagus [Automatically generated definition]." . _:genid124243 oboInOwl:source "ncithesaurus:Esophageal_Mucosa" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "UMLS:C0227176" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:hasDbXref "FMA:62996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "esophagus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "esophagus mucous membrane" . [] oboInOwl:hasDbXref "FMA:62996", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "lamina muscularis mucosae oesophageae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "mucosa of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "mucosa of oesophagus" . [] oboInOwl:hasDbXref "FMA:62996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "mucous membrane of oesophagus" . [] oboInOwl:hasDbXref "FMA:62996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "oesophageal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "oesophagus mucous membrane" . [] oboInOwl:hasDbXref "FMA:62996", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "tunica mucosa oesophageae" . [] oboInOwl:hasDbXref "FMA:62996" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "muscularis mucosae of oesophagus" . [] oboInOwl:hasDbXref "BTO:0002859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002469 ; owl:annotatedTarget "tunica mucosa oesophagi" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget _:genid125199 . _:genid124262 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/303", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 . [] oboInOwl:hasDbXref "MA:0002714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "autopod" . _:genid124264 oboInOwl:source "ncithesaurus:Paw" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "UMLS:C0687080" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002390 . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "autopodial limb segment" . _:genid124266 oboInOwl:hasDbXref "FMA:83015" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "distal free limb segment" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 . [] oboInOwl:hasDbXref "FMA:83015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "distal segment of free limb" . [] oboInOwl:hasDbXref "EMAPA:32722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002470 ; owl:annotatedTarget "distal segment of limb" . _:genid124271 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0005562, obo:UBERON_0011584 . [] oboInOwl:hasDbXref "PHENOSCAPE:curators", "https://github.com/obophenotype/uberon/issues/101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus)." . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "epipodium" . [] oboInOwl:hasDbXref "FMA:83016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "middle free limb segment" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "zeugopod limb segment" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "zeugopodial limb segment" . [] oboInOwl:hasDbXref "FMA:83016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002471 ; owl:annotatedTarget "middle segment of free limb" . (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0011583 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002472 ; owl:annotatedTarget "The proximal free limb segment. Includes as parts the stylopod skeleton." . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002472 ; owl:annotatedTarget "propodium" . [] oboInOwl:hasDbXref "FMA:83014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002472 ; owl:annotatedTarget "proximal free limb segment" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002472 ; owl:annotatedTarget "stylopodial limb segment" . [] oboInOwl:hasDbXref "FMA:83014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002472 ; owl:annotatedTarget "proximal segment of free limb" . _:genid124294 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001020 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002812 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002813 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001735 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "CAS:492-61-5" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002473 ; owl:annotatedTarget "A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum." . [] oboInOwl:hasDbXref "MA:0002721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002473 ; owl:annotatedTarget "interhemispheric commissure" . [] oboInOwl:source "NIF-isa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget _:genid125244 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget _:genid125246 . [] oboInOwl:hasDbXref "BIRNLEX:970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "A composite structure of the brain stem, which is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)[NIF, based on NN]." . [] oboInOwl:source "BIRNLEX:970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "UMLS:C0228514" . [] oboInOwl:source "BIRNLEX:970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "neuronames:224" . [] oboInOwl:hasDbXref "BIRNLEX:970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "cerebellar peduncles and decussations" . [] oboInOwl:hasDbXref "FMA:77791", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "pedunculi cerebellares" . [] oboInOwl:hasDbXref "NeuroNames:224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "basal ganglia (anatomic)" . [] oboInOwl:hasDbXref "NeuroNames:224" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "corpus striatum (Savel'ev)" . [] oboInOwl:hasDbXref "NeuroNames:224" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "ganglia basales" . [] oboInOwl:hasDbXref "FMA:77791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002474 ; owl:annotatedTarget "set of cerebellar peduncles" . _:genid124314 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015059 _:genid124316 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010214 . _:genid124316 a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001994, obo:UBERON_0002481 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget _:genid125262 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget _:genid125264 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget _:genid125266 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0004457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000345" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "Endochondral ossification of the lateral sides of the braincase.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "Large median unpaired cartilage bone consisting of two diverging plates. Positioned medial to the eye. The orbitosphenoid develops from the Trabeculae communis and forms the anterior and anterolateral boundary of the orbital foramen and constitutes a significant part of the sidewalls and floor of the cranial cavity. Bordered by the lateral ethmoid anteriorly, and the pterosphenoid posteriorly, The orbitosphenoid may extend ventrally to meet the parasphenoid. In the adult, the orbitosphenoid is fused ventrally to the parasphenoid via a thin sheet of bone.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship loss: develops_from taenia marginalis anterior (TAO:0001505)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship loss: overlaps orbitosphenoid-lateral ethmoid joint (TAO:0001941)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship loss: overlaps orbitosphenoid-prootic joint (TAO:0001794)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship loss: overlaps pterosphenoid-orbitosphenoid joint (TAO:0001831)[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000345" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship loss: part_of braincase and otic capsule skeleton (AAO:0000052)[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: develops_from neurocranium (UBERON:0001703)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000253" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: part_of neurocranium (UBERON:0001703)[TAO]" . [] oboInOwl:hasDbXref "FMA:52869" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "ala minor (os sphenoidale)" . [] oboInOwl:hasDbXref "FMA:52869", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "ala minor ossis sphenoidalis" . _:genid124337 oboInOwl:hasDbXref "FMA:52869" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "ingrassia's process" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004461 . [] oboInOwl:hasDbXref "FMA:52869" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "lesser wing of sphenoid" . _:genid124339 oboInOwl:hasDbXref "FMA:52869" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "lesser wing of sphenoidal bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "orbitosphenoid bone" . [] oboInOwl:hasDbXref "Wikipedia:Lesser_wing_of_sphenoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "alae parvae" . [] oboInOwl:hasDbXref "MA:0002773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "lesser wing of sphenoid bone" . [] oboInOwl:hasDbXref "ZFA:0000253" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002478 ; owl:annotatedTarget "orbitosphenoids" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget obo:UBERON_0004755 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000047", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000047" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]" . [] oboInOwl:source "ncithesaurus:Bone_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "UMLS:C0391978" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "osteogenic tissue" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." . [] oboInOwl:hasDbXref "XAO:0004040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "mineralized bone tissue" . [] oboInOwl:hasDbXref "MESH:A02.835.232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "bone" . [] oboInOwl:hasDbXref "FMA:224804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002481 ; owl:annotatedTarget "portion of bone tissue" . [] oboInOwl:hasDbXref "Wikipedia:Bone#Woven_or_lamellar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002482 ; owl:annotatedTarget "Bone tissue that has a regular parallel alignment of collagen into sheets (lamellae) and is mechanically strong." . _:genid124354 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002482 ; owl:annotatedTarget "EMAPA:37625" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004465 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "basophilic normoblast" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0000130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow." . [] oboInOwl:hasDbXref "FMA:24019", "MA:0002782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "cancellous bone" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "substantia spongiosa" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "substantia spongiosa ossium" . [] oboInOwl:hasDbXref "FMA:24019", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "substantia trabecularis" . _:genid124366 oboInOwl:hasDbXref "BTO:0001700" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "cancellated bone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002343 . [] oboInOwl:hasDbXref "BTO:0001700" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "substantia trabecularis ossium" . [] oboInOwl:hasDbXref "BTO:0001700" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002483 ; owl:annotatedTarget "trabecular substance" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "early erythroblast" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000065", "PMID:10709991" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002484 ; owl:annotatedTarget "The medullary cavities of the bones where bone marrow is stored." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002484 ; owl:annotatedTarget "not clear if the FMA intends to have two classes. MP:0000065: 'the medullary cavities of the bones.'. NCITA also has 'medullary bone'" . [] oboInOwl:hasDbXref "FMA:83698" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002484 ; owl:annotatedTarget "marrow cavity" . [] oboInOwl:hasDbXref "FMA:83698" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002484 ; owl:annotatedTarget "medullary cavity" . ( ) . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "early normoblast" . [] oboInOwl:source "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002485 ; owl:annotatedTarget _:genid125325 . [] oboInOwl:hasDbXref "MP:0009734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002485 ; owl:annotatedTarget "The minute canals that pass the prostatic secretions to the urethra." . [] oboInOwl:source "ncithesaurus:Prostatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002485 ; owl:annotatedTarget "UMLS:C0227965" . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002486 ; owl:annotatedTarget "The vocal apparatus of the larynx, which includes the vocal cords and the opening between them." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010610" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BMZ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002486 ; owl:annotatedTarget "A small, slit-like aperture lying longitudinally on the floor of the pharynx.[AAO]" . _:genid124387 oboInOwl:source "ncithesaurus:Glottis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002486 ; owl:annotatedTarget "UMLS:C0017681" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000351 . _:genid124389 oboInOwl:source "Wikipedia-uncited" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002488 ; owl:annotatedTarget _:genid125336 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001076 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000549 ; owl:annotatedTarget "prorubricyte" . [] oboInOwl:hasDbXref "Wikipedia:Helix" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002488 ; owl:annotatedTarget "The helix is the prominent rim of the pinna." . _:genid124391 oboInOwl:source "ncithesaurus:Helix" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002488 ; owl:annotatedTarget "UMLS:C0229304" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002497 . [] oboInOwl:hasDbXref "MA:0002793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002488 ; owl:annotatedTarget "helix" . _:genid124393 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003685 _:genid124395 _:genid124397 ) ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0007173 . _:genid124395 a owl:Restriction ; owl:onProperty obo:RO_0002176, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0000209, obo:UBERON_0001112 . _:genid124397 a owl:Restriction ; owl:onProperty obo:RO_0002176, obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0000210, obo:UBERON_0001125 . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "Drug_Central:845" . [] oboInOwl:hasDbXref "ISBN:0-8036-0655-9", "MGI:smb", "MP:0003840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002489 ; owl:annotatedTarget "The dense, fibrous connective tissue joint between the tetrapod parietal bones and the frontal bone." . [] oboInOwl:hasDbXref "PMID:11784098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002489 ; owl:annotatedTarget "fronto-parietal suture" . [] oboInOwl:hasDbXref "PMID:11784098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002489 ; owl:annotatedTarget "frontoparietal suture" . [] oboInOwl:hasDbXref "Wikipedia:Coronal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002489 ; owl:annotatedTarget "sutura coronalis" . _:genid124406 a owl:Restriction ; owl:onClass obo:UBERON_0000209 ; owl:onProperty obo:RO_0002005, obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:someValuesFrom obo:UBERON_0003726 . _:genid124408 oboInOwl:notes "two halves of the frontal bone" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget _:genid125356 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000975 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget "A suture that connects the two frontal bones of the skull." . _:genid124410 oboInOwl:hasDbXref "Wikipedia:Frontal_suture" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget "sutura frontalis" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001105 . [] oboInOwl:hasDbXref "FMA:52989", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget "sutura metopica" . _:genid124412 oboInOwl:hasDbXref "MA:0002796" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget "metopic suture" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000976 . [] oboInOwl:hasDbXref "Wikipedia:Frontal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002490 ; owl:annotatedTarget "sutura frontalis" . ( ) . ( ) . [] oboInOwl:source "HP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002491 ; owl:annotatedTarget _:genid125372 . [] oboInOwl:hasDbXref "ISBN:0-8036-0655-9", "MGI:smb", "MP:0003841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002491 ; owl:annotatedTarget "The dense, fibrous connective tissue joint between the parietal bones and the occipital bone." . [] oboInOwl:hasDbXref "MA:0002797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002491 ; owl:annotatedTarget "lambdoidal suture" . [] oboInOwl:hasDbXref "Wikipedia:Lambdoid_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002491 ; owl:annotatedTarget "sutura lambdoidea" . [] oboInOwl:notes "both parietals" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002492 ; owl:annotatedTarget _:genid125382 . [] oboInOwl:hasDbXref "ISBN:0-8036-0655-9", "MGI:smb", "MP:0003843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002492 ; owl:annotatedTarget "The dense, fibrous connective tissue joint between the tetrapod parietal bones." . [] oboInOwl:hasDbXref "Wikipedia:Sagittal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002492 ; owl:annotatedTarget "sutura sagittalis" . [] oboInOwl:hasDbXref "Wikipedia:Long_bone", "https://medlineplus.gov/ency/imagepages/9582.htm" ; oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/2010", "https://github.com/obophenotype/uberon/issues/32" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002495 ; owl:annotatedTarget "A long bone is a bone that has a shaft and 2 ends and is longer than it is wide. Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow. The ends of a long bone contain spongy bone and an epiphyseal plate or line depending on the stage of development. The epiphyseal plate is a hyaline cartilage, where new bone growth takes place, lengthening the bone prior to adulthood. Bone lengthening ceases when this cartilage is lost, leaving a remnant referred to as an epiphyseal line." . [] oboInOwl:source "ncithesaurus:Long_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002495 ; owl:annotatedTarget "UMLS:C0222647" . [] oboInOwl:hasDbXref "BTO:0004256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002495 ; owl:annotatedTarget "os longum" . [] oboInOwl:hasDbXref "VSAO:0005067" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "Region of the scapula where the latter meets with the clavicle: attachment point of the clavicle to the scapula in some taxa." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000826" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "Anterior rounded projection of the pars acromialis of the scapula.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000826" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "relationship loss: part_of pars acromialis (AAO:0000752)[AAO]" . [] oboInOwl:source "ncithesaurus:Acromion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "UMLS:C0001209" . [] oboInOwl:hasDbXref "VSAO:0005067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "acromion process" . [] oboInOwl:hasDbXref "VSAO:0005067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "scapular acromion" . [] oboInOwl:hasDbXref "Wikipedia:Acromion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "acromion of scapula" . [] oboInOwl:hasDbXref "Wikipedia:Acromion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002497 ; owl:annotatedTarget "acromion of the scapula" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0004353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "A rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches." . [] oboInOwl:hasDbXref "AAO:0000736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "crista ventralis" . _:genid124453 oboInOwl:hasDbXref "AAO:0000736", "MP:0004353" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid crest" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001460 . [] oboInOwl:hasDbXref "MP:0004353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid eminence" . [] oboInOwl:hasDbXref "MP:0004353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid impression" . [] oboInOwl:hasDbXref "FMA:23418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid tuberosity" . [] oboInOwl:hasDbXref "FMA:23418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid tuberosity of humerus" . [] oboInOwl:hasDbXref "FMA:23418", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "tuberositas deltoidea" . [] oboInOwl:hasDbXref "Wikipedia:Deltoid_tuberosity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "tuberositas deltoidea humeri" . [] oboInOwl:hasDbXref "AAO:0000736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "crista ventralis humeri" . [] oboInOwl:hasDbXref "MP:0004353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002498 ; owl:annotatedTarget "deltoid process" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002499 ; owl:annotatedTarget _:genid125413 . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_labyrinth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002499 ; owl:annotatedTarget "The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Cochlear_Labyrinth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002499 ; owl:annotatedTarget "UMLS:C0931689" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002500 ; owl:annotatedTarget obo:UBERON_0011164 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002500 ; owl:annotatedTarget _:genid125419 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0004469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002500 ; owl:annotatedTarget "The bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone." . [] oboInOwl:source "ncithesaurus:Zygomatic_Arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002500 ; owl:annotatedTarget "UMLS:C0162485" . [] oboInOwl:hasDbXref "Wikipedia:Zygomatic_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002500 ; owl:annotatedTarget "arcus zygomaticus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002503 ; owl:annotatedTarget _:genid125424 . [] oboInOwl:hasDbXref "Wikipedia:Greater_trochanter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002503 ; owl:annotatedTarget "The greater trochanter (great trochanter) of the femur is a large, irregular, quadrilateral eminence and a part of the skeletal system. It is directed a little lateralward and backward, and, in the adult, is about 1 cm lower than the head. Because the pelvic outlet in the female is larger than in the male, there is a greater distance between the greater trochanters in the female. It has two surfaces and four borders. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002503 ; owl:annotatedTarget "EMAPA:37594" . [] oboInOwl:source "ncithesaurus:Great_Trochanter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002503 ; owl:annotatedTarget "UMLS:C0223865" . [] oboInOwl:hasDbXref "Wikipedia:Greater_trochanter" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002503 ; owl:annotatedTarget "trochanter major" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002504 ; owl:annotatedTarget _:genid125430 . [] oboInOwl:hasDbXref "Wikipedia:Lesser_trochanter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002504 ; owl:annotatedTarget "The lesser trochanter (small trochanter) of the femur is a conical eminence, which varies in size in different subjects [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002504 ; owl:annotatedTarget "EMAPA:37595" . [] oboInOwl:source "ncithesaurus:Lesser_Trochanter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002504 ; owl:annotatedTarget "UMLS:C0223866" . [] oboInOwl:hasDbXref "Wikipedia:Lesser_trochanter" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002504 ; owl:annotatedTarget "trochanter minor" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget obo:UBERON_0000488 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget _:genid125441 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget _:genid125443 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "An epithelium that is part of a iris [Automatically generated definition]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "epithelial tissue of iris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "epithelium of iris" . [] oboInOwl:hasDbXref "FMA:58517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "epithelium pigmentosum (iris)" . [] oboInOwl:hasDbXref "FMA:58517", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "epithelium pigmentosum iridis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "iris epithelial tissue" . [] oboInOwl:hasDbXref "FMA:58517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "iris epithelium" . [] oboInOwl:hasDbXref "FMA:58517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "pigmented epithelium of iris" . [] oboInOwl:hasDbXref "MA:0002826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002506 ; owl:annotatedTarget "iris pigmented epithelium" . _:genid124498 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000916 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "Gmelin:648637" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002507 ; owl:annotatedTarget "A lymph node that is part of an abdomen [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002507 ; owl:annotatedTarget "abdomen lymph node" . [] oboInOwl:hasDbXref "FMA:12787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002507 ; owl:annotatedTarget "parietal abdominal lymph node" . _:genid124509 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002509 ; owl:annotatedTarget obo:UBERON_0015860 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002193 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "intermediate erythroblast" . [] oboInOwl:hasDbXref "MP:0005232" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002509 ; owl:annotatedTarget "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." . _:genid124511 oboInOwl:source "ncithesaurus:Mesenteric_Lymph_Node" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002509 ; owl:annotatedTarget "UMLS:C0229792" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003061 . [] oboInOwl:hasDbXref "BTO:0000767" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002509 ; owl:annotatedTarget "nodi lymphoidei mesenterici" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "intermediate normoblast" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget obo:UBERON_0006683 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_fontanelle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "In humans, the anterior fontanelle (bregmatic fontanelle, frontal fontanelle) is the largest, and is placed at the junction of the sagittal suture, coronal suture, and frontal suture; it is lozenge-shaped, and measures about 4 cm in its antero-posterior and 2.5 cm in its transverse diameter. The fontanelle allows the skull to deform during birth to ease its passage through the birth canal and for expansion of the brain after birth. While the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior is not completely closed until about the middle of the second year. Full ossification starts in the late twenties and finishes before the age of 50 . [WP,unvetted]." . [] oboInOwl:external_ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "TAO:0001739 anterior cranial fontanel is 'Fontanel that is located between the contralateral frontals and anterior to the epiphyseal bar'" . [] oboInOwl:hasDbXref "FMA:75439" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "anterior fontanelle" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_fontanelle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "bregmatic fontanelle" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_fontanelle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "fonticulus anterior" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_fontanelle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002510 ; owl:annotatedTarget "frontal fontanelle" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatic erythroblast" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget obo:UBERON_0010363 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget _:genid125490 . [] oboInOwl:hasDbXref "GO:0001958", "GO_REF:0000034", "VSAO:0000145", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/54" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "Replacement bone that forms within cartilage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000145" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "Replacement bone that forms within cartilage.[VSAO]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "some structures, e.g. in ZFA are both intramembrane and endochondral" . [] oboInOwl:hasDbXref "VSAO:0000145" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "ossified chondrogenic bone" . [] oboInOwl:hasDbXref "BTO:0002157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "cartilaginous bone" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatic normoblast" . [] oboInOwl:hasDbXref "ZFA:0001591" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002513 ; owl:annotatedTarget "endochondral bones" . _:genid124541 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003104, obo:UBERON_0010020 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:hasDbXref "GO:0001957", "Wikipedia:Intramembranous_ossification", "https://github.com/obophenotype/uberon/issues/267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001644" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget "Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0001644" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget "[In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001635" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget "intramembranous bones" . [] oboInOwl:hasDbXref "AEO:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002514 ; owl:annotatedTarget "membrane bone" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "polychromatophilic normoblast" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002515 ; owl:annotatedTarget "The thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints." . [] oboInOwl:source "ncithesaurus:Periosteum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002515 ; owl:annotatedTarget "UMLS:C0031110" . [] oboInOwl:hasDbXref "Wikipedia:Epiphyseal_plate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "A hyaline cartilage plate in the metaphysis at each end of a long bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line." . [] oboInOwl:hasDbXref "FMA:75427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "epiphysial plate" . [] oboInOwl:hasDbXref "MA:0002839" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "long bone epiphyseal plate" . [] oboInOwl:hasDbXref "BTO:0000412" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "cartilago epiphysialis" . [] oboInOwl:hasDbXref "BTO:0000412" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "epiphyseal disk" . _:genid124559 oboInOwl:hasDbXref "BTO:0000412" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "epiphyseal growth disk" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001173 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000550 ; owl:annotatedTarget "rubricyte" . [] oboInOwl:hasDbXref "MA:0002839" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "growth plate" . _:genid124561 oboInOwl:hasDbXref "Wikipedia:Epiphyseal_plate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "lamina epiphysialis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008835 . [] oboInOwl:hasDbXref "BTO:0000412" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002516 ; owl:annotatedTarget "physis" . [] oboInOwl:hasDbXref "Wikipedia:Base_of_skull" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002517 ; owl:annotatedTarget "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." . [] oboInOwl:source "ncithesaurus:Base_of_the_Skull" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002517 ; owl:annotatedTarget "UMLS:C0149543" . [] oboInOwl:hasDbXref "FMA:52801" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002517 ; owl:annotatedTarget "base of skull" . [] oboInOwl:hasDbXref "FMA:52801", "FMA:TA", "Wikipedia:Base_of_skull" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002517 ; owl:annotatedTarget "basis cranii" . [] oboInOwl:hasDbXref "FMA:52801", "MA:0002840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002517 ; owl:annotatedTarget "cranial base" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002521 ; owl:annotatedTarget "Connective tissue composed of elastic fibers." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002521 ; owl:annotatedTarget "textus connectivus elasticus" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget obo:UBERON_0004797 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget _:genid125537 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget _:genid125539 . [] oboInOwl:hasDbXref "Wikipedia:Tunica_media" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget "The middle layer of an artery or vein. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Tunica_Media" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget "UMLS:C0162867" . [] oboInOwl:hasDbXref "BTO:0002011", "Wikipedia:Tunica_media" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002522 ; owl:annotatedTarget "tunica media vasorum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget obo:UBERON_0004923 . [] oboInOwl:notes "check for exceptions, e.g. capillaries" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget _:genid125547 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget _:genid125549 . [] oboInOwl:hasDbXref "ISBN:0073040584", "NCIT:C33820", "Wikipedia:Tunica_intima" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." . [] oboInOwl:ontology "Wikipedia" ; oboInOwl:source "Wikipedia:Tunica_intima" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia]" . [] oboInOwl:source "ncithesaurus:Tunica_Intima" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "UMLS:C0162864" . _:genid124592 oboInOwl:hasDbXref "BTO:0002012" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "Bichat's tunic" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012072 . [] oboInOwl:hasDbXref "BTO:0002012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "intima" . [] oboInOwl:hasDbXref "BTO:0002012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002523 ; owl:annotatedTarget "tunica intima vasorum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "A lymph node that is part of a pancreas [Automatically generated definition]." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "PMID:19443021" . [] oboInOwl:source "ncithesaurus:Pancreatic_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "UMLS:C0229783" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "lymph node of pancreas" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "pancreas lymph node" . [] oboInOwl:hasDbXref "FMA:16626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "aJCC level 19 node" . [] oboInOwl:hasDbXref "MA:0002881" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002527 ; owl:annotatedTarget "pyloric lymph node" . (obo:UBERON_0000029 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005473 ] ) . ( ) . [] oboInOwl:hasDbXref "ncithesaurus:Sacral_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002528 ; owl:annotatedTarget "A lymph node located in the sacral region." . _:genid124610 oboInOwl:source "ncithesaurus:Sacral_Lymph_Node" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002528 ; owl:annotatedTarget "UMLS:C0229827" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . _:genid124613 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002101, obo:UBERON_0010334 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002529 ; owl:annotatedTarget "A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002529 ; owl:annotatedTarget "FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z" . [] oboInOwl:source "ncithesaurus:Extremity_Part" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002529 ; owl:annotatedTarget "UMLS:C1268195" . [] oboInOwl:hasDbXref "FMA:241863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002529 ; owl:annotatedTarget "free limb segment" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0002163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002530 ; owl:annotatedTarget "An organ that functions as a secretory or excretory organ." . [] oboInOwl:source "ncithesaurus:Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002530 ; owl:annotatedTarget "UMLS:C1285092" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002530 ; owl:annotatedTarget "glandular organ" . [] oboInOwl:hasDbXref "BTO:0000522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002530 ; owl:annotatedTarget "Druese" . [] oboInOwl:hasDbXref "BTO:0000522", "Wikipedia:Gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002530 ; owl:annotatedTarget "glandula" . [] oboInOwl:hasDbXref "Wikipedia:Epiblast", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000243" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000243" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "epiblast" . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "ectoblast" . [] oboInOwl:hasDbXref "Wikipedia:Epiblast" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "epiblastus" . [] oboInOwl:hasDbXref "VHOG:0000243" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002532 ; owl:annotatedTarget "primitive ectoderm" . [] oboInOwl:hasDbXref "BTO:0001445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011104" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0815318960", "OMD:tail+bud" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget obo:CL_0000765 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000201" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (5) a larva or embryo with a postanal tail.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "tail bud" . [] oboInOwl:hasDbXref "BTO:0001445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "end bud" . [] oboInOwl:hasDbXref "ZFA:0000077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002533 ; owl:annotatedTarget "tail bud mesenchyme" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." . [] oboInOwl:hasDbXref "Wikipedia:Ovotestis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002537 ; owl:annotatedTarget "A gonad with both testicular and ovarian aspects[WP]." . [] oboInOwl:hasDbXref "GO:0040035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002537 ; owl:annotatedTarget "hermaphrodite genitalia" . [] oboInOwl:hasDbXref "Wikipedia:Ovotestis#In_gastropods" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002537 ; owl:annotatedTarget "glandula hermaphroditica" . [] oboInOwl:hasDbXref "Wikipedia:Ovotestis#In_gastropods" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002537 ; owl:annotatedTarget "hermaphrodite gland" . [] oboInOwl:hasDbXref "BTO:0000981" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002537 ; owl:annotatedTarget "ovotestis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget obo:UBERON_0010188 . [] oboInOwl:source "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget _:genid125620 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget _:genid125622 . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "acidophilic erythroblast" . [] oboInOwl:source "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget _:genid125624 . _:genid124661 oboInOwl:hasDbXref "PMID:16313389", "ZFA:yb", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010359" ; oboInOwl:ontology "AAO" ; oboInOwl:source "NLM:branchial+arch" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000155" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pharyngeal_Arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "UMLS:C0080322" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "pharyngeal arches" . [] oboInOwl:hasDbXref "BTO:0001785", "MP:0002884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "branchial arch" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002539 ; owl:annotatedTarget "arcus pharyngei" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "eosinophilic erythroblast" . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget _:genid125637 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans)." . _:genid124677 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000944" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature07339 Boisvert CA, Mark-Kurik E and Ahlberg PE, The pectoral fin of Panderichthys and the origin of digits. Nature (2008)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "Our reinterpretation of the distal fin endoskeleton of Panderichthys removes the final piece of evidence supporting the formerly popular hypothesis that tetrapod digits are wholly new structures without homologues in sarcopterygian fish fins. This hypothesis, which was based partly on the complete absence of plausible digit homologues in Panderichthys (then the closest known relative of tetrapods), has already been called into question by the discovery of digit-like radials in Tiktaalik and the fact that Hox gene expression patterns closely resembling those associated with digit formation in tetrapods occur in the distal fin skeletons of paddlefish and Australian lungfish. Our new data show that Panderichthys is not an anomaly: like Tiktaalik and other fish members of the Tetrapodomorpha, it has distal radials that can be interpreted as digit homologues.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003887 . [] oboInOwl:notes "GAT" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "FMA:85518" . [] oboInOwl:source "ncithesaurus:Digit" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "UMLS:C0582802" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "orthochromatic normoblast" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "digit (phalangeal portion) plus soft tissue" . [] oboInOwl:hasDbXref "MA:0000690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002544 ; owl:annotatedTarget "limb digit" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget obo:UBERON_0005085 . [] oboInOwl:hasDbXref "http://www.ncbi.nlm.nih.gov/books/NBK53175/", "https://github.com/obophenotype/uberon/issues/135", "https://github.com/seger/aao/issues/4", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." . [] oboInOwl:source "PMID:11523831" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons" . [] oboInOwl:hasDbXref "FMA:293966", "PMID:22512454" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "ectodermal placode" . [] oboInOwl:hasDbXref "Wikipedia:Placode" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "placode" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "ectodermal cranial placode" . [] oboInOwl:hasDbXref "XAO:0000305" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002546 ; owl:annotatedTarget "cranial placodes" . [] oboInOwl:hasDbXref "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000552 ; owl:annotatedTarget "pyknotic eto enrythroblast" . [] oboInOwl:hasDbXref "FMA:67552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002553 ; owl:annotatedTarget "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002553 ; owl:annotatedTarget "EMAPA:37442" . [] oboInOwl:hasDbXref "FMA:12237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002558 ; owl:annotatedTarget "cavity of organ" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002561 ; owl:annotatedTarget "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "PMID:25568069" . [] oboInOwl:source "DOI:10.1186/s12983-014-0089-2" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0002561 ; owl:annotatedTarget obo:NCBITaxon_569425 . [] oboInOwl:hasDbXref "FMA:75007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002561 ; owl:annotatedTarget "cavity of neuraxis" . _:genid124702 oboInOwl:hasDbXref "FMA:75007" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002561 ; owl:annotatedTarget "cavity of ventricular system of neuraxis" ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0002359 . [] oboInOwl:hasDbXref "FMA:75007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002561 ; owl:annotatedTarget "neuraxis cavity" . _:genid124705 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002152, obo:UBERON_0015410 . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "Ventral subdivision of the pons which consists of the massive pontine pertuberance on pontine ventral surface." . [] oboInOwl:source "BIRNLEX:1043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "UMLS:C0228427" . [] oboInOwl:source "BIRNLEX:1043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "neuronames:616" . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "basal portion of pons" . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "base of pons" . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "basilar part of pons" . [] oboInOwl:hasDbXref "FMA:72244", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "pars basilaris pontis" . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "pons proper" . [] oboInOwl:hasDbXref "FMA:72244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "ventral portion of pons" . [] oboInOwl:hasDbXref "NeuroNames:616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "basal part of the pons" . [] oboInOwl:hasDbXref "NeuroNames:616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "basilar pons" . [] oboInOwl:hasDbXref "NeuroNames:616" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "basis pontis" . [] oboInOwl:hasDbXref "NeuroNames:616" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "pars anterior pontis" . [] oboInOwl:hasDbXref "NeuroNames:616" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002567 ; owl:annotatedTarget "pars ventralis pontis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget _:genid125690 . [] oboInOwl:hasDbXref "BIRNLEX:1089", "Wikipedia:Decussation_of_superior_cerebellar_peduncle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "Regional part of superior cerebellar peduncle located in the caudal midbrain, at the level of the inferior colliculus, consisting of a large bundle of fibers crossing the midline. It contains fibers projecting from the deep cerebellar nucleus to the midbrain and thalamus through the superior cerebellar peduncle (MM). The decussation of superior cerebellar peduncle is the portion of the superior cerebellar peduncle which crosses into the midbrain. [WP,unvetted]." . [] oboInOwl:source "BIRNLEX:1089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "UMLS:C0152374" . [] oboInOwl:source "BIRNLEX:1089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "neuronames:527" . [] oboInOwl:hasDbXref "FMA:72455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "Wernekink's decussation" . [] oboInOwl:hasDbXref "FMA:72455", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussatio pedunculorum cerebellarium superiorum" . [] oboInOwl:hasDbXref "FMA:72455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussation of brachium conjunctivum" . [] oboInOwl:hasDbXref "FMA:72455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussation of superior cerebellar peduncles" . [] oboInOwl:hasDbXref "FMA:72455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "superior cerebellar peduncle decussation" . _:genid124733 oboInOwl:hasDbXref "NeuroNames:527" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussatio brachii conjunctivi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000010 . [] oboInOwl:hasDbXref "NeuroNames:527" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussatio crurorum cerebello-cerebralium" . [] oboInOwl:hasDbXref "NeuroNames:527" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussation of the superior cerebellar peduncle" . [] oboInOwl:hasDbXref "NeuroNames:527" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "decussation of the superior cerebellar peduncle (Wernekinck)" . [] oboInOwl:hasDbXref "BAMS:dscp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002588 ; owl:annotatedTarget "descussation of the scp" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget obo:UBERON_0007702 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget _:genid125706 . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget _:genid125708 . [] oboInOwl:hasDbXref "BIRNLEX:1095" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "Part of the corticospinal tract located in the spinal cord, formed as 75 to 90% of the corticospinal fibers cross to the opposite side of the brainstem in the pyramidal decussation. This tract descends the length of the spinal cord in the lateral white column (Adapted from Brain Info)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "EMAPA:37888" . [] oboInOwl:source "BIRNLEX:1095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "UMLS:C0152402" . [] oboInOwl:source "BIRNLEX:1095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "neuronames:801" . [] oboInOwl:hasDbXref "MBA:1019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "corticospinal tract, crossed" . [] oboInOwl:hasDbXref "FMA:72635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "lateral pyramidal tract" . [] oboInOwl:hasDbXref "BAMS:py" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "pyramidal tract, crossed" . [] oboInOwl:hasDbXref "NeuroNames:2954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "corticospinal tract, crossed" . [] oboInOwl:hasDbXref "NeuroNames:2954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "crossed corticospinal tract" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_corticospinal_tract" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "fasciculus cerebrospinalis lateralis" . _:genid124751 oboInOwl:hasDbXref "NeuroNames:2954" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "lateral corticospinal tract" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000997 . [] oboInOwl:hasDbXref "NeuroNames:801" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "lateral corticospinal tract of the medulla" . _:genid124753 oboInOwl:hasDbXref "NeuroNames:801" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "tractus corticospinalis (pyramidalis) lateralis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005876 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_corticospinal_tract" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002589 ; owl:annotatedTarget "tractus corticospinalis lateralis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget obo:UBERON_0016526 . [] oboInOwl:hasDbXref "BIRNLEX:1128" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem." . [] oboInOwl:source "BIRNLEX:1128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "UMLS:C0458337" . [] oboInOwl:source "BIRNLEX:1128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "neuronames:834" . [] oboInOwl:hasDbXref "FMA:72719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "fornicate gyrus" . [] oboInOwl:hasDbXref "NeuroNames:834" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "fornicate convolution" . [] oboInOwl:hasDbXref "NeuroNames:834" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "fornicate lobe" . [] oboInOwl:hasDbXref "NeuroNames:834" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "gyrus fornicatus" . [] oboInOwl:hasDbXref "Wikipedia:Limbic_lobe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002600 ; owl:annotatedTarget "lobus limbicus" . [] oboInOwl:inconsistent_with "MA" ; oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget _:genid125733 . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_nuclei" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget "The cochlear nuclei consist of: (a) the dorsal cochlear nucleus, corresponding to the tuberculum acusticum on the dorso-lateral surface of the inferior peduncle; and (b) the ventral or accessory cochlear nucleus, placed between the two divisions of the nerve, on the ventral aspect of the inferior peduncle. [WP,unvetted]." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002126 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002162 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002591 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002864 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002866 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0002873 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget obo:UBERON_0007633 . [] oboInOwl:source "BIRNLEX:1151", "ncithesaurus:Cochlear_Nuclei" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget "UMLS:C0152411" . [] oboInOwl:source "BIRNLEX:1151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget "neuronames:720" . [] oboInOwl:hasDbXref "FMA:72240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget "cochlear nuclei" . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002610 ; owl:annotatedTarget "nuclei cochleares" . [] oboInOwl:hasDbXref "BIRNLEX:1167" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." . [] oboInOwl:source "ncithesaurus:Brain_Part" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "UMLS:C0445620" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "anatomical structure of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "biological structure of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "brain anatomical structure" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "brain biological structure" . [] oboInOwl:hasDbXref "FMA:55676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "neuraxis segment" . [] oboInOwl:hasDbXref "BIRNLEX:1167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002616 ; owl:annotatedTarget "segment of brain" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget _:genid125764 . [] oboInOwl:hasDbXref "BIRNLEX:1313" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone)." . [] oboInOwl:source "MP:0012682" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "Any of the groups of neural nuclei situated in the septal region which have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala." . [] oboInOwl:source "Wikipedia:Septal_nuclei" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "The septal nuclei are structures in the middle anteroventral cerebrum that are composed of medium-size neurons grouped into medial, lateral, and posterior groups. The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens. In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly in order to experience a euphoric feeling (i.e. press a bar to receive electrical current that will stimulate the neurons). [WP,unvetted][Wikipedia:Septal_nuclei]." . [] oboInOwl:external_ontology "NIF" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "in NIFSTD this is the mereological sum of the individual complexes - in MA it is the superclass" . [] oboInOwl:source "BIRNLEX:1313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "UMLS:C0036687" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "PMID:31537530" . [] oboInOwl:hasDbXref "FMA:61845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "parolfactory nuclei" . [] oboInOwl:hasDbXref "FMA:61845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "septal nuclei" . [] oboInOwl:hasDbXref "MA:0002978" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "septal nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Septal_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002663 ; owl:annotatedTarget "nuclei septales" . [] oboInOwl:source "ABA", "FMA", "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget _:genid125775 . [] oboInOwl:source "Wikipedia:Vestibular_nuclei" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget _:genid125777 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "Nuclear complex containing the vestibular nuclei." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0001719 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002127 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002154 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002155 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002559 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002870 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002871 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002872 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget obo:UBERON_0002877 . [] oboInOwl:source "BIRNLEX:1337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "UMLS:C0042600" . [] oboInOwl:source "BIRNLEX:1337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "neuronames:714" . [] oboInOwl:hasDbXref "FMA:72239", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "nuclei vestibulares in medulla oblongata" . [] oboInOwl:hasDbXref "FMA:72239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "vestibular nuclei" . [] oboInOwl:hasDbXref "FMA:72239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "vestibular nuclei in medulla oblongata" . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "nuclei vestibulares" . [] oboInOwl:hasDbXref "GO:0021750" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002673 ; owl:annotatedTarget "vestibular nucleus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0000126 . [] oboInOwl:conflicts "ABA", "ZFA" ; oboInOwl:source "GO", "MA", "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget _:genid125797 . [] oboInOwl:hasDbXref "BIRNLEX:1366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "Nucleus located beneath the floor of the 4th ventricle in the pontine tegmentum, containing motor neurons innervating the lateral rectus muscle of the eye (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0002143 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0002147 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0002149 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0002633 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0002963 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0003011 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget obo:UBERON_0007632 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000713" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ISBN:3764351209" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "Hindbrain motor nucleus which is the origin of motor axons of cranial nerve VI. From Neuroanatomy of the Zebrafish Brain.[TAO]" . [] oboInOwl:external_ontology "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "part of medulla oblongata in ABA and ZFA; part of pons in MA and pontine tegmentum in NIF; note that pons/medulla are spatially disjoint in ABA." . [] oboInOwl:source "BIRNLEX:1366", "ncithesaurus:Abducens_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "UMLS:C0152407" . [] oboInOwl:source "BIRNLEX:1366" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "neuronames:585" . [] oboInOwl:hasDbXref "MA:0001010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducens VI nucleus" . [] oboInOwl:hasDbXref "TAO:0000713" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducens motor nuclei" . [] oboInOwl:hasDbXref "ZFA:0000713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducens motor nucleus" . [] oboInOwl:hasDbXref "FMA:54504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducens nerve nucleus" . _:genid124841 oboInOwl:hasDbXref "FMA:54504" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducent nucleus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000203 . [] oboInOwl:hasDbXref "ZFA:0000713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "motor nucleus VI" . _:genid124843 oboInOwl:hasDbXref "ZFA:0000713" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nVI" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 . [] oboInOwl:hasDbXref "FMA:54504", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nucleus nervi abducentis" . [] oboInOwl:hasDbXref "FMA:54504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nucleus of abducens nerve" . [] oboInOwl:hasDbXref "FMA:54504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nucleus of abducens nerve (VI)" . [] oboInOwl:hasDbXref "FMA:54504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "sixth cranial nerve nucleus" . [] oboInOwl:hasDbXref "NeuroNames:585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "abducens nucleus proper" . [] oboInOwl:hasDbXref "NeuroNames:585" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nucleus abducens" . [] oboInOwl:hasDbXref "Wikipedia:Abducens_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002682 ; owl:annotatedTarget "nucleus nervi abducentis" . [] oboInOwl:notes "In NIFSTD this is a tract of brain but this leads to issues due to its overlap with the spinal cord" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget obo:UBERON_0001018 . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget _:genid125826 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0002878" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract." . [] oboInOwl:hasDbXref "BIRNLEX:1464", "MP:0002878", "neuronames:1320" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "pyramidal tract" . [] oboInOwl:source "BIRNLEX:1464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "UMLS:C0034229" . [] oboInOwl:source "BIRNLEX:1464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "neuronames:800" . [] oboInOwl:hasDbXref "NeuroNames:1320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "corticospinal fibers" . [] oboInOwl:hasDbXref "NeuroNames:1320" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "fasciculus cerebro-spinalis" . _:genid124861 oboInOwl:hasDbXref "NeuroNames:800" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "fasciculus pyramidalis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013149 . [] oboInOwl:hasDbXref "NeuroNames:1320" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "fibrae corticospinales" . [] oboInOwl:hasDbXref "NeuroNames:800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "pyramid (Willis)" . [] oboInOwl:hasDbXref "NeuroNames:1320" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "tractus cortico-spinalis" . [] oboInOwl:hasDbXref "NeuroNames:1320", "Wikipedia:Corticospinal_tract" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "tractus corticospinalis" . [] oboInOwl:hasDbXref "NeuroNames:800" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002707 ; owl:annotatedTarget "tractus pyramidalis" . [] oboInOwl:hasDbXref "BIRNLEX:1488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "Nucleus in the midbrain at the level of the inferior colliculus near the midline, containing the motor neurons giving rise to the trochlear nerve, innervating the contralateral superior oblique extraocular muscle of the eye (Brodal, Neurological Anatomy, 3rd ed, 1981, pg. 533)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0001715 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0001944 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0001947 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0001966 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0002141 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0002438 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0002691 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0002696 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0002995 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget obo:UBERON_0003040 . [] oboInOwl:source "BIRNLEX:1488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "UMLS:C0152406" . [] oboInOwl:source "BIRNLEX:1488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "neuronames:513" . [] oboInOwl:hasDbXref "FMA:54518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "fourth cranial nerve nucleus" . [] oboInOwl:hasDbXref "ZFA:0000450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "motor nucleus IV" . [] oboInOwl:hasDbXref "ZFA:0000450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "nIV" . [] oboInOwl:hasDbXref "FMA:54518", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "nucleus nervi trochlearis" . [] oboInOwl:hasDbXref "FMA:54518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "nucleus of trochlear nerve" . [] oboInOwl:hasDbXref "MA:0001075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "trochlear IV nucleus" . [] oboInOwl:hasDbXref "ZFA:0000450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "trochlear motor nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Trochlear_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002722 ; owl:annotatedTarget "nucleus nervi trochlearis" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "A spinal cord segment that adjacent_to a cervical region." . [] oboInOwl:source "BIRNLEX:1499", "ncithesaurus:Cervical_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "UMLS:C0581619" . [] oboInOwl:source "BIRNLEX:1499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "UMLS:C1278837" . [] oboInOwl:hasDbXref "FMA:71166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "cervical segment of spinal cord" . [] oboInOwl:hasDbXref "FMA:71166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "cervical segments of spinal cord [1-8]" . [] oboInOwl:hasDbXref "FMA:71166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "cervical spinal cord" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "PMID:32568414" . [] oboInOwl:hasDbXref "FMA:71166", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "pars cervicalis medullae spinalis" . [] oboInOwl:hasDbXref "FMA:71166", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002726 ; owl:annotatedTarget "segmenta cervicalia medullae spinalis [1-8" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget _:genid125877 . _:genid124905 oboInOwl:hasDbXref "Wikipedia:Septum_pellucidum#Layers" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "One of two layers of both white and gray matter of the septum pellucidum. During fetal development there is a space between the two laminae called the cavum septum pellucidum which, in ninety per cent of cases, disappears during infancy." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002348 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "FMA classifies as white matter" . _:genid124907 oboInOwl:source "BIRNLEX:1554" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "UMLS:C0152278" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002349 . [] oboInOwl:source "BIRNLEX:1554" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "neuronames:258" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "laminae septi pellucidi" . [] oboInOwl:hasDbXref "FMA:62472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "septum pellucidum lamina" . [] oboInOwl:hasDbXref "NeuroNames:258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "lamina of the septum pellucidum" . [] oboInOwl:hasDbXref "NeuroNames:258" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002742 ; owl:annotatedTarget "lamina septi pellucidi" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002743 ; owl:annotatedTarget _:genid125889 . [] oboInOwl:hasDbXref "BIRNLEX:1560" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002743 ; owl:annotatedTarget "A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert." . [] oboInOwl:source "BIRNLEX:1560" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002743 ; owl:annotatedTarget "neuronames:1997" . [] oboInOwl:hasDbXref "NeuroNames:1997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002743 ; owl:annotatedTarget "basal forebrain area" . [] oboInOwl:hasDbXref "Wikipedia:Basal_forebrain" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002743 ; owl:annotatedTarget "pars basalis telencephali" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002749 ; owl:annotatedTarget "A regional part of brain that is part of a cerebellar cortex [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:76924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002749 ; owl:annotatedTarget "cerebellar cortical segment" . [] oboInOwl:hasDbXref "BIRNLEX:1571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002749 ; owl:annotatedTarget "segment of cerebellar cortex" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget _:genid125906 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=23125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "The crossing of the two trochlear nerves at their exit through the velum medullare anterius." . [] oboInOwl:source "BIRNLEX:1690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "UMLS:C0175448" . [] oboInOwl:source "BIRNLEX:1690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "neuronames:595" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=23125" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussatio fibrarum nervorum trochlearium" . [] oboInOwl:hasDbXref "FMA:72488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussation of trochlear nerve (IV)" . [] oboInOwl:hasDbXref "DHBA:12338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussation of trochlear nerve fibers" . [] oboInOwl:hasDbXref "FMA:72488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "trochlear neural decussation" . [] oboInOwl:hasDbXref "NeuroNames:595" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussatio nervorum trochlearium" . [] oboInOwl:hasDbXref "NeuroNames:595" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussatio trochlearis" . [] oboInOwl:hasDbXref "NeuroNames:595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "decussation of the trochlear nerve" . [] oboInOwl:hasDbXref "BAMS:4x" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "trochlear decussation" . [] oboInOwl:hasDbXref "NeuroNames:595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002787 ; owl:annotatedTarget "trochlear nerve decussation" . [] oboInOwl:hasDbXref "Wikipedia:Lumbar_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "." . [] oboInOwl:source "BIRNLEX:1704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "UMLS:C0581620" . [] oboInOwl:source "ncithesaurus:Lumbar_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "UMLS:C0581621" . [] oboInOwl:source "BIRNLEX:1704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "UMLS:C1278838" . [] oboInOwl:hasDbXref "FMA:71168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "lumbar segment of spinal cord" . [] oboInOwl:hasDbXref "FMA:71168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "lumbar segments of spinal cord [1-5]" . [] oboInOwl:hasDbXref "FMA:71168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "lumbar spinal cord" . [] oboInOwl:hasDbXref "FMA:71168", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "pars lumbalis medullae spinalis" . [] oboInOwl:hasDbXref "FMA:71168", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "segmenta lumbalia medullae spinalis [1-5]" . _:genid124955 oboInOwl:hasDbXref "MA:0003083" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002792 ; owl:annotatedTarget "spinal cord lumbar segment" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000204 . (obo:UBERON_0001872 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 ] ) . ( ) . _:genid124961 oboInOwl:hasDbXref "BIRNLEX:1728" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002802 ; owl:annotatedTarget "Parietal lobe of the left hemisphere of the brain." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006098 . [] oboInOwl:source "BIRNLEX:1728" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002802 ; owl:annotatedTarget "UMLS:C1281960" . [] oboInOwl:hasDbXref "BIRNLEX:1729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002803 ; owl:annotatedTarget "Parietal lobe of the right hemisphere of the brain." . [] oboInOwl:source "BIRNLEX:1729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002803 ; owl:annotatedTarget "UMLS:C1281959" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002804 ; owl:annotatedTarget "A limbic lobe that is part of a left cerebral hemisphere." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002805 ; owl:annotatedTarget "A limbic lobe that is part of a right cerebral hemisphere." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002808 ; owl:annotatedTarget "A temporal lobe that is part of a left cerebral hemisphere." . [] oboInOwl:source "BIRNLEX:1784" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002808 ; owl:annotatedTarget "UMLS:C1281971" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002809 ; owl:annotatedTarget "A temporal lobe that is part of a right cerebral hemisphere." . [] oboInOwl:source "BIRNLEX:1785" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002809 ; owl:annotatedTarget "UMLS:C1281970" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002810 ; owl:annotatedTarget "A frontal cortex that is part of a right cerebral hemisphere." . [] oboInOwl:source "BIRNLEX:1786" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002810 ; owl:annotatedTarget "UMLS:C1281954" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "Reaxys:1281607" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002811 ; owl:annotatedTarget "A frontal cortex that is part of a left cerebral hemisphere." . [] oboInOwl:source "BIRNLEX:1787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002811 ; owl:annotatedTarget "UMLS:C1281955" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002812 ; owl:annotatedTarget "A cerebral hemisphere that is in the left side of a brain." . [] oboInOwl:source "ncithesaurus:Left_Cerebral_Hemisphere" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002812 ; owl:annotatedTarget "UMLS:C0228176" . [] oboInOwl:hasDbXref "BIRNLEX:1795" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002812 ; owl:annotatedTarget "left hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002813 ; owl:annotatedTarget "A cerebral hemisphere that is in the right side of a brain." . [] oboInOwl:source "ncithesaurus:Right_Cerebral_Hemisphere" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002813 ; owl:annotatedTarget "UMLS:C0228175" . [] oboInOwl:hasDbXref "BIRNLEX:1797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002813 ; owl:annotatedTarget "right hemisphere" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget obo:UBERON_0001800 . [] oboInOwl:hasDbXref "Wikipedia:Scarpa%27s_ganglion", "http://www.dartmouth.edu/~humananatomy/part_8/chapter_44.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "The ganglion of the vestibular nerve. It contains the cell bodies of the bipolar primary afferent neurons whose peripheral processes form synaptic contact with hair cells of the vestibular sensory end organs[WP,unvetted]. Distributed to the maculae of the utricle and saccule and to the ampullary crests of the semicircular ducts. The vestibular fibers arise in bipolar cells in the vestibular ganglion in the internal acoustic meatus." . [] oboInOwl:source "BIRNLEX:2549", "ncithesaurus:Vestibular_Ganglion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "UMLS:C0036286" . [] oboInOwl:hasDbXref "PMID:11722431", "PMID:12482498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "CFU-Meg" . [] oboInOwl:source "BIRNLEX:2549" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "UMLS:C0446706" . [] oboInOwl:source "BIRNLEX:2549" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "neuronames:495" . [] oboInOwl:hasDbXref "FMA:53435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "Scarpa's ganglion" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "vestibular part of vestibulocochlear ganglion" . [] oboInOwl:hasDbXref "MA:0001086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "vestibulocochlear VIII ganglion vestibular component" . [] oboInOwl:hasDbXref "NeuroNames:495" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "nucleus nervi oculomotorii, pars medialis" . [] oboInOwl:hasDbXref "EMAPA:17573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002824 ; owl:annotatedTarget "vestibulocochlear ganglion vestibular component" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget obo:UBERON_0001714 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget _:genid126016 . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget _:genid126018 . [] oboInOwl:hasDbXref "PMCID:PMC1794060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "Meg-CFC" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget _:genid126020 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget _:genid126022 . [] oboInOwl:hasDbXref "MGI:smb", "MP:0003703" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "The group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000588" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "The sensory ganglion of the ear. (See Anatomical Atlas entry for statoacoustic ganglion by T. Whitfield.)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000696" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:21452441 Park BY, Saint-Jeannet JP, Induction and Segregation of the Vertebrate Cranial Placodes. Developmental Biology (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "(During the development of the inner ear in a vertebrate embryo) As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII.[well established][VHOG]" . _:genid125045 oboInOwl:source "Wikipedia:Cochlear_nerve" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "The cell bodies of the cochlear nerve lie within the central aspect of the cochlea and are collectively known as the spiral ganglion. This name reflects the fact that the cell bodies, considered as a unit, have a spiral (or perhaps more accurately, a helical) shape, reflecting the shape of the cochlea. The terms 'cochlear nerve fiber' and 'spiral ganglion cell' are used, to some degree, interchangeably, although the former may be used to more specifically refer to the central axons of the cochlear nerve. These central axons exit the cochlea at its base, where it forms a nerve trunk. In humans, this aspect of the nerve is roughly one inch in length. It projects centrally to the brainstem, where its fibers synapse with the cell bodies of the cochlear nucleus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001987 . [] oboInOwl:hasDbXref "ZFA:0000588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "SAG" . [] oboInOwl:source "BIRNLEX:2564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "UMLS:C0037959" . [] oboInOwl:source "BIRNLEX:2564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "neuronames:496" . [] oboInOwl:hasDbXref "EMAPA:16982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "acoustic ganglion VIII" . [] oboInOwl:hasDbXref "PMID:21116988" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "MkP" . [] oboInOwl:hasDbXref "EHDAA2:0002196" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "acoustico-vestibular VIII ganglion" . [] oboInOwl:hasDbXref "ZFA:0000588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "auditory ganglion" . [] oboInOwl:hasDbXref "ZFA:0000588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "gVIII" . [] oboInOwl:hasDbXref "ZFA:0000588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "statoacoustic (VIII) ganglion" . [] oboInOwl:hasDbXref "ZFA:0000588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "statoacoustic ganglia" . [] oboInOwl:hasDbXref "XAO:0004142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "statoacoustic ganglion" . [] oboInOwl:hasDbXref "MA:0001084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "vestibulocochlear VIII ganglion" . [] oboInOwl:hasDbXref "VHOG:0000696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "acoustic ganglion" . [] oboInOwl:hasDbXref "BIRNLEX:2564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "auditory ganglion" . [] oboInOwl:hasDbXref "NeuroNames:496" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "nucleus nervi oculomotorii ventrolateralis" . [] oboInOwl:hasDbXref "PMID:12482498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000553 ; owl:annotatedTarget "megakaryocytic progenitor cell" . [] oboInOwl:hasDbXref "NeuroNames:496" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "nucleus nervi oculomotorii, pars ventralis" . [] oboInOwl:hasDbXref "VHOG:0000696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "statoacoustic VIII ganglion" . [] oboInOwl:hasDbXref "XAO:0004142" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002827 ; owl:annotatedTarget "vestibulocochlear ganglia" . (obo:UBERON_0000126 [ a owl:Restriction ; owl:onProperty core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0001650 ] ) . [] oboInOwl:hasDbXref "BIRNLEX:2644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453)." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0001719 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002127 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002154 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002155 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002559 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002673 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002870 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002872 . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget obo:UBERON_0002877 . [] oboInOwl:source "BIRNLEX:2644", "ncithesaurus:Hypoglossal_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "UMLS:C0228802" . [] oboInOwl:source "BIRNLEX:2644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "neuronames:757" . [] oboInOwl:hasDbXref "MA:0001039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "hypoglossal XII nucleus" . [] oboInOwl:hasDbXref "FMA:54505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "hypoglossal nerve nucleus" . [] oboInOwl:hasDbXref "FMA:54505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "hypoglossal nucleus" . [] oboInOwl:hasDbXref "FMA:54505", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "nucleus nervi hypoglossi" . [] oboInOwl:hasDbXref "FMA:54505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "nucleus of hypoglossal nerve" . [] oboInOwl:hasDbXref "FMA:54505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "twelfth cranial nerve nucleus" . [] oboInOwl:hasDbXref "NeuroNames:757" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "nucleus hypoglossalis" . [] oboInOwl:hasDbXref "Wikipedia:Hypoglossal_nucleus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002871 ; owl:annotatedTarget "nucleus nervi hypoglossi" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000556 ; owl:annotatedTarget obo:CL_0000763 . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget _:genid126076 . [] oboInOwl:hasDbXref "Wikipedia:Central_sulcus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "The central sulcus is a fold in the cerebral cortex of brains in vertebrates. Also called the central fissure, it was originally called the fissure of Rolando or the Rolandic fissure, after Luigi Rolando. The central sulcus is a prominent landmark of the brain, separating the parietal lobe from the frontal lobe and the primary motor cortex from the primary somatosensory cortex. [WP,unvetted]." . [] oboInOwl:hasDbXref "BIRNLEX:4035", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "CS" . [] oboInOwl:source "BIRNLEX:4035", "ncithesaurus:Central_Sulcus_of_Rolando" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "UMLS:C0228188" . [] oboInOwl:source "BIRNLEX:4035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "UMLS:C1281071" . [] oboInOwl:source "BIRNLEX:4035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "neuronames:48" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "BETA-D-GLUCOSE" . [] oboInOwl:hasDbXref "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000556 ; owl:annotatedTarget "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." . [] oboInOwl:hasDbXref "FMA:83752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "central cerebral sulcus" . [] oboInOwl:hasDbXref "FMA:83752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "central fissure" . [] oboInOwl:hasDbXref "BIRNLEX:4035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "rolandic fissure" . [] oboInOwl:hasDbXref "BIRNLEX:4035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "sulcus centralis" . [] oboInOwl:hasDbXref "BIRNLEX:4035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "sulcus centralis (rolandi)" . [] oboInOwl:hasDbXref "BIRNLEX:4035", "Wikipedia:Central_sulcus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002916 ; owl:annotatedTarget "sulcus centralis cerebri" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget obo:UBERON_0014466 . [] oboInOwl:hasDbXref "Wikipedia:Medial_longitudinal_fissure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "The deep groove which separates the two hemispheres of the vertebrate brain. The falx cerebri, a dural brain covering, lies within the medial longitudinal fissure. [WP,unvetted]." . [] oboInOwl:hasDbXref "BIRNLEX:4041", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "LF" . [] oboInOwl:source "BIRNLEX:4041", "ncithesaurus:Longitudinal_Fissure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "UMLS:C0228186" . [] oboInOwl:source "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "neuronames:35" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "fissura interhemispherica" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "fissura longitudinalis cerebrales" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "fissura longitudinalis cerebri" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "fissura longitudinalis magna" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "hemispheric sulcus" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "interhemispheric fissure" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "longitudinal cerebral fissure" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "longitudinal fissure of hemisphere" . [] oboInOwl:hasDbXref "BIRNLEX:4041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "longitudinal fissure of the cerebrum" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "longitudinal sulcus" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "medial longitudinal fissure" . [] oboInOwl:hasDbXref "FMA:83727" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002921 ; owl:annotatedTarget "sagittal fissure" . _:genid125123 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007641 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006210 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget obo:UBERON_0002308 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "A nucleus of brain that is part of a trigeminal nuclear complex." . _:genid125130 oboInOwl:external_ontology "GO" ; oboInOwl:url "https://github.com/obophenotype/mouse-anatomy-ontology/issues/58" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001322 . [] oboInOwl:source "ncithesaurus:Trigeminal_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "UMLS:C0040999" . _:genid125132 oboInOwl:hasDbXref "FMA:71247" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "nucleus of trigeminal nuclear complex" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000979 . [] oboInOwl:hasDbXref "MA:0001028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "trigeminal V nucleus" . _:genid125134 oboInOwl:hasDbXref "FMA:71247" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "trigeminal nuclear complex nucleus" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001446 . [] oboInOwl:hasDbXref "FMA:71248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "trigeminal nucleus" . _:genid125136 oboInOwl:hasDbXref "BTO:0001074" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "nucleus mesencephalicus nervi trigemini" ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0001378 . [] oboInOwl:hasDbXref "BTO:0001074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "nucleus mesencephalicus trigeminalis" . [] oboInOwl:hasDbXref "BTO:0001074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002925 ; owl:annotatedTarget "nucleus tractus mesencephali nervi trigeminalis" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002926 ; owl:annotatedTarget _:genid126126 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002926 ; owl:annotatedTarget "A sensory epithelium that is part of a gustatory system." . [] oboInOwl:hasDbXref "GO:0021681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget obo:UBERON_0002979 . [] oboInOwl:source "ncithesaurus:Granular_Layer_of_the_Cerebellum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "UMLS:C1708253" . _:genid125155 oboInOwl:source "BIRNLEX:779" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "neuronames:363" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002193 . [] oboInOwl:hasDbXref "GO:0021681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "cerebellar granular layer" . [] oboInOwl:hasDbXref "MA:0000993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "cerebellum granule cell layer" . [] oboInOwl:hasDbXref "BIRNLEX:779" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "granule cell layer of cerebellar cortex" . [] oboInOwl:hasDbXref "BTO:0004425" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "stratum granulosum cerebelli" . [] oboInOwl:hasDbXref "FMA:83140", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "stratum granulosum corticis cerebelli" . [] oboInOwl:hasDbXref "BTO:0004425" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002956 ; owl:annotatedTarget "granular layer of cerebellum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0002988 ; owl:annotatedTarget obo:UBERON_0001503 . [] oboInOwl:hasDbXref "FMA:37424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002988 ; owl:annotatedTarget "abductor indicis" . [] oboInOwl:hasDbXref "FMA:37424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0002988 ; owl:annotatedTarget "first dorsal interosseous of hand" . [] oboInOwl:hasDbXref "FMA:37424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0002988 ; owl:annotatedTarget "first dorsal interosseous muscle of hand" . [] oboInOwl:hasDbXref "BIRNLEX:923" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." . [] oboInOwl:source "BIRNLEX:923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "UMLS:C0228426" . [] oboInOwl:source "BIRNLEX:923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "neuronames:557" . [] oboInOwl:hasDbXref "FMA:71108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "dorsal portion of pons" . [] oboInOwl:hasDbXref "FMA:71108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "tegmental portion of pons" . [] oboInOwl:hasDbXref "FMA:71108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "tegmentum of pons" . [] oboInOwl:hasDbXref "FMA:71108", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "tegmentum pontis" . [] oboInOwl:hasDbXref "NeuroNames:557" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "pars dorsalis pontis" . [] oboInOwl:hasDbXref "NeuroNames:557" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "pars posterior pontis" . [] oboInOwl:hasDbXref "Wikipedia:Pontine_tegmentum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003023 ; owl:annotatedTarget "tegmentum pontis" . [] oboInOwl:hasDbXref "Wikipedia:Septum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003037 ; owl:annotatedTarget "A wall, dividing a cavity or structure into smaller ones[WP]." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003037 ; owl:annotatedTarget "septa" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_spinal_cord" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." . [] oboInOwl:source "BIRNLEX:966", "ncithesaurus:Thoracic_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "UMLS:C0581620" . [] oboInOwl:hasDbXref "FMA:71167", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "pars thoracica medullae spinalis" . [] oboInOwl:hasDbXref "FMA:71167", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "segmenta thoracica medullae spinalis [1-12]" . [] oboInOwl:hasDbXref "FMA:71167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "thoracic region of spinal cord" . [] oboInOwl:hasDbXref "FMA:71167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "thoracic segment of spinal cord" . [] oboInOwl:hasDbXref "FMA:71167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "thoracic segments of spinal cord [1-12]" . [] oboInOwl:hasDbXref "FMA:71167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003038 ; owl:annotatedTarget "thoracic spinal cord" . _:genid125199 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000935, obo:UBERON_0010130 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "beta-D-Glucose" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget obo:UBERON_0003043 . [] oboInOwl:hasDbXref "MP:0010859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "The horseshoe-shaped tract that connects the two olfactory bulbs." . [] oboInOwl:hasDbXref "MP:0008230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "pars anterior" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "EMAPA:37404" . [] oboInOwl:hasDbXref "MP:0010859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "anterior commissure pars anterior" . [] oboInOwl:hasDbXref "FMA:61963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "anterior commissure, anterior part" . [] oboInOwl:hasDbXref "FMA:61963", "MP:0008230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "anterior part of anterior commissure" . [] oboInOwl:hasDbXref "FMA:61963", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "commissura anterior, crus anterius" . [] oboInOwl:hasDbXref "FMA:61963", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "commissura anterior, pars anterior" . [] oboInOwl:hasDbXref "FMA:61963", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "commissura anterior, pars olfactoria" . [] oboInOwl:hasDbXref "FMA:61963", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "commissura rostralis, pars anterior" . [] oboInOwl:hasDbXref "FMA:61963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "olfactory limb of anterior commissure" . [] oboInOwl:hasDbXref "FMA:61963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "olfactory part of anterior commissure" . [] oboInOwl:hasDbXref "MP:0008230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "pars anterior commissurae anterioris" . [] oboInOwl:hasDbXref "FMA:61963", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "pars olfactoria commissurae anterioris" . [] oboInOwl:hasDbXref "BAMS:aco" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "anterior commissure olfactory limb" . [] oboInOwl:hasDbXref "BAMS:aco" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003039 ; owl:annotatedTarget "anterior commissure, olfactory limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "A nerve fiber that is part of a trigeminal nerve." . [] oboInOwl:source "BIRNLEX:974" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "UMLS:C0175452" . [] oboInOwl:source "BIRNLEX:974" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "neuronames:607" . [] oboInOwl:hasDbXref "FMA:72501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "central part of trigeminal nerve" . [] oboInOwl:hasDbXref "FMA:72501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "trigeminal nerve fibers" . [] oboInOwl:hasDbXref "FMA:72501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "trigeminal nerve tract" . [] oboInOwl:hasDbXref "NeuroNames:607" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003041 ; owl:annotatedTarget "fibrae nervi trigemini" . [] oboInOwl:hasDbXref "MP:0010860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "The major forebrain commissure that connects the two temporal lobes of the cortex." . [] oboInOwl:hasDbXref "MP:0008229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "pars posterior" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "EMAPA:37410" . _:genid125244 oboInOwl:source "BIRNLEX:977" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "UMLS:C0175210" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002317 . [] oboInOwl:hasDbXref "MP:0010860" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "anterior commissure pars posterior" . _:genid125246 oboInOwl:hasDbXref "MP:0008230" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "anterior commissure temporal limb" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014891 . [] oboInOwl:hasDbXref "FMA:61964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "anterior commissure, posterior part" . [] oboInOwl:hasDbXref "FMA:61964", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "commissura anterior, crus posterius" . [] oboInOwl:hasDbXref "FMA:61964", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "commissura anterior, pars posterior" . [] oboInOwl:hasDbXref "FMA:61964", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "commissura rostralis, pars posterior" . [] oboInOwl:hasDbXref "FMA:61964", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "pars posterior commissurae anterioris" . [] oboInOwl:hasDbXref "FMA:61964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "temporal limb of anterior commissure" . [] oboInOwl:hasDbXref "BAMS:act" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003043 ; owl:annotatedTarget "anterior commissure, temporal limb" . [] oboInOwl:contradicted_by "NCBIBook:NBK53171" ; oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget obo:UBERON_0009955 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget _:genid126239 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_placode", "XAO:0000005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000186" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG]" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget "olfactory placodes" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget "placoda nasalis" . _:genid125262 oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003050 ; owl:annotatedTarget "placoda olfactoria" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 . (obo:UBERON_0007499 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000924 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001846 ] ) . ( ) . [] oboInOwl:hasDbXref "MP:0009806", "Wikipedia:Otic_vesicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000051" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001148" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "One of the paired sacs of invaginated ectoderm that develop into the membranous labyrinth of the internal ear. [Biology_online][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001148" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.413", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "The inner ear develops embryonically in all vertebrates as an invagination of the ectodermal otic placode to form an otic vesicle.[well established][VHOG]" . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "MP defines as epithelial sac, but EHDAA defines as multi-tissue; See https://github.com/obophenotype/uberon/issues/1305" . [] oboInOwl:source "ncithesaurus:Otic_Vesicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "UMLS:C1518678" . [] oboInOwl:hasDbXref "MP:0004311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "otic vesicle" . [] oboInOwl:hasDbXref "VHOG:0001148" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "acoustic vesicle" . [] oboInOwl:hasDbXref "BTO:0002661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "auditory vesicle" . [] oboInOwl:hasDbXref "MP:0004311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003051 ; owl:annotatedTarget "otocyst" . [] oboInOwl:inconsistent_with "ZFA" ; oboInOwl:source "https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/106/" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget obo:UBERON_0007651 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget _:genid126273 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget _:genid126275 . [] oboInOwl:hasDbXref "GO:0021555" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000649" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget "Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]" . [] oboInOwl:hasDbXref "XAO:0000016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget "isthmic organizer territory" . [] oboInOwl:hasDbXref "VHOG:0000649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget "isthmo-cerebellar region" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003052 ; owl:annotatedTarget "isthmus/MHB" . [] oboInOwl:hasDbXref "GO:0021509", "PMID:15378040" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "A single row of glia at the dorsal midline of the developing neural tube along the entire anterior-posterior axis. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0007058" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "Multi-tissue structure that is the dorsal-most aspect of the devleloping neural tube.[TAO]" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "beta-D-glucopyranose" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:hasDbXref "VHOG:0000303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "roof plate neural tube" . [] oboInOwl:hasDbXref "ZFA:0001436" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "roof plate neural tube region" . [] oboInOwl:hasDbXref "Wikipedia:Roof_plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "alar plate" . [] oboInOwl:hasDbXref "EMAPA:35361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003054 ; owl:annotatedTarget "future brain roof plate" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget obo:UBERON_0000487 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget _:genid126292 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget _:genid126294 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget _:genid126296 . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001185" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO]" . [] oboInOwl:hasDbXref "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001185" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO]" . [] oboInOwl:source "ncithesaurus:Periderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "UMLS:C1518973" . [] oboInOwl:hasDbXref "EHDAA2:0001846" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "skin periderm" . [] oboInOwl:hasDbXref "ZFA:0001185" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "EVL" . [] oboInOwl:hasDbXref "MP:0013530" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003055 ; owl:annotatedTarget "epitrichium" . [] oboInOwl:hasDbXref "XB:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003056 ; owl:annotatedTarget "The portion of neural plate anterior to the mid-hindbrain junction." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001200" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003056 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "CFU-C , Colony forming unit in culture" . [] oboInOwl:hasDbXref "XB:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003057 ; owl:annotatedTarget "The portion of neural plate posterior to the mid-hindbrain junction." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001201" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003057 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . _:genid125325 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002329, obo:UBERON_0003820 . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "CFU-GM" . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget _:genid126320 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000279" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000559" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1006/dbio.2001.0460 Schubert M, Holland LZ, Dale Stokes M and Holland ND, Three Amphoxius Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates. Developmental Biology (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "unsegmented paraxial mesoderm" . [] oboInOwl:hasDbXref "GO:0002075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "somitomeric mesoderm" . _:genid125336 oboInOwl:hasDbXref "VHOG:0000559" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003059 ; owl:annotatedTarget "unsegmented mesenchyme" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0016611 . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget obo:UBERON_0009201 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget _:genid126330 . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "GMP" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget _:genid126332 . [] oboInOwl:hasDbXref "Wikipedia:Pronephric_duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000150" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "Duct of the embryonic kidney, present bilaterally ventral to the somites and leading to the anal region where it empties separately from, and just posterior to the anus. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000082" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "The first-formed kidney duct, which drains the kidney of most anamniotes and becomes the ductus deferens of male amniotes. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-3, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000082" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.686", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "(...) in all craniates, the archinephric duct develops in embryogeny.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pronephric_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "UMLS:C1283945" . [] oboInOwl:hasDbXref "VHOG:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "archinephric duct" . [] oboInOwl:hasDbXref "Wikipedia:Pronephric_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "ductus pronephricus" . [] oboInOwl:hasDbXref "ZFA:0000150" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003060 ; owl:annotatedTarget "pronephric ducts" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "colony forming unit granulocyte macrophage" . [] oboInOwl:hasDbXref "Wikipedia:Blood_island_of_umbilical_vesicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000094" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011006" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000094" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO]" . _:genid125356 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000085" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.450, DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual Review of Cell and Developmental Biology (2006)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG]" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000209 . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac" . [] oboInOwl:source "ncithesaurus:Blood_Island" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "UMLS:C1511224" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003061 ; owl:annotatedTarget "blood islands" . [] oboInOwl:hasDbXref "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000557 ; owl:annotatedTarget "granulocyte-macrophage progenitor" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget _:genid126353 . [] oboInOwl:todo "PMID:16313393" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget _:genid126355 . [] oboInOwl:hasDbXref "ISBN:0838580343", "MP:0004387" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000060" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000086" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000086" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1525-142x.2000.00073.x Neidert AH, Panopoulou G and Langeland JA, Amphioxus goosecoid and the evolution of the head organizer and prechordal plate. Evolution and Development (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG]" . [] oboInOwl:hasDbXref "XAO:0000079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "head mesenchyme" . [] oboInOwl:hasDbXref "XAO:0000079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003063 ; owl:annotatedTarget "head mesoderm" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget _:genid126364 . _:genid125372 oboInOwl:source "EMAPA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget _:genid126366 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004339 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget _:genid126368 . [] oboInOwl:hasDbXref "GOC:curators", "Wikipedia:Intermediate_mesoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010575" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000087" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "Wikipedia:Mesoderm, ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "(...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm')." . [] oboInOwl:source "ncithesaurus:Intermediate_Mesoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "UMLS:C1284010" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "intermediate mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:16178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "intermediate plate" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "intermediate plate mesoderm" . _:genid125382 oboInOwl:hasDbXref "Wikipedia:Intermediate_mesoderm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003064 ; owl:annotatedTarget "mesenchyma intermedium" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000210 . [] oboInOwl:hasDbXref "PMID:12784288", "ZFIN:yb", "https://github.com/obophenotype/uberon/issues/258" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010363" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "The second of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000297" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "in XAO, develops from visceral pouch 2" . [] oboInOwl:hasDbXref "Wikipedia:Second_pharyngeal_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "arcus pharyngeus secundus" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "branchial arch 2" . [] oboInOwl:hasDbXref "XAO:0000098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "hyoid arch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "second branchial arch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "second visceral arch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "visceral arch 2" . [] oboInOwl:hasDbXref "EHDAA2:0000050" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "2nd arch" . [] oboInOwl:hasDbXref "VHOG:0000297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "2nd visceral arch" . [] oboInOwl:hasDbXref "VHOG:0000297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003066 ; owl:annotatedTarget "pharyngeal arches 2" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003067 ; owl:annotatedTarget obo:UBERON_0009955 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003067 ; owl:annotatedTarget "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000103" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003067 ; owl:annotatedTarget "In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "beta-D-glucose" . [] oboInOwl:hasDbXref "ZFA:0001310" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003067 ; owl:annotatedTarget "dorsolateral placodes" . [] oboInOwl:hasDbXref "GO:0048318", "Wikipedia:Chordamesoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003068 ; owl:annotatedTarget "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000107" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003068 ; owl:annotatedTarget "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Chordamesoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003068 ; owl:annotatedTarget "chordamesoderm" . [] oboInOwl:notes "invaginates" ; oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget obo:UBERON_0003067 . [] oboInOwl:hasDbXref "NCBIBook:NBK53175", "Wikipedia:Otic_placode" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000138" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "Primordium of the ear epithelium before it hollows into the otic vesicle, present beside the hindbrain rudiment in the midsegmentation period. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000235" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG]" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "With the exception of the pigment cells of the stria vascularis and the secretory epithelium of the cochlea, which are of neural crest origin, all compo- nents of the inner ear derive from the otic placode. In most species the thickening of the ectoderm into a placode occurs in a region adjacent to rhombomere 5 (reviewed in Ohyama et al., 2007), while in amphibians the otic placode is centered onto rhombomere 4 (Ruiz i Altaba and Jessell, 1991)." . _:genid125413 oboInOwl:source "ncithesaurus:Otic_Placodes" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "UMLS:C1518677" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001849 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "placoda otica" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "octaval VIII placode" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003069 ; owl:annotatedTarget "octaval placode" . [] oboInOwl:source "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget obo:UBERON_0003067 . _:genid125419 oboInOwl:hasDbXref "PMID:22512454", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/693" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "The ectodermal precursor of the trigeminal ganglion. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24.[XAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000162" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "The ectodermal rudiment of the trigeminal ganglion, distinguishable during much of the segmentation period. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000109" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "The dorsolateral placodes (trigeminal and vestibular) develop from ectoderm lateral to the brain (...). In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0004209", "VHOG:0000109", "XAO:0000225", "ZFA:0000162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "trigeminal placode" . _:genid125424 oboInOwl:hasDbXref "ISBN:0471888893" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "profundus V placode" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004412 . [] oboInOwl:hasDbXref "ISBN:0471888893" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "profundus placode" . [] oboInOwl:hasDbXref "ZFA:0000162" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003070 ; owl:annotatedTarget "trigeminal placodes" . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "PMID:16496288", "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget _:genid126430 . [] oboInOwl:hasDbXref "GO:0046619", "ZFA:0000570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "eye placode" . [] oboInOwl:hasDbXref "GO:0046619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "optic placode" . [] oboInOwl:hasDbXref "GO:0046619", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "optic placode of camera-type eye" . [] oboInOwl:hasDbXref "XAO:0000227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "eye anlage" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003071 ; owl:annotatedTarget "optic placodes" . _:genid125441 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0001769, obo:UBERON_0003073 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget _:genid126440 . _:genid125443 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget _:genid126442 ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0048770 . [] oboInOwl:hasDbXref "MP:0004269", "Wikipedia:Optic_cup_(embryology)", "ZFA:0001202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000167" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Optic_Cup" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "UMLS:C0231109" . [] oboInOwl:hasDbXref "BTO:0005351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "eyecup" . [] oboInOwl:hasDbXref "VHOG:0000167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "ocular cup" . [] oboInOwl:hasDbXref "BTO:0005351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003072 ; owl:annotatedTarget "ophtalmic cup" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget _:genid126456 . [] oboInOwl:hasDbXref "Wikipedia:Lens_placode", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000122" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000166" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" . [] oboInOwl:source "ncithesaurus:Lens_Placodes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "UMLS:C1517770" . [] oboInOwl:hasDbXref "ZFA:0000122" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "lens placodes" . [] oboInOwl:hasDbXref "Wikipedia:Lens_placode" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003073 ; owl:annotatedTarget "placoda lentis" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget obo:UBERON_0009201 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget _:genid126469 . [] oboInOwl:hasDbXref "Wikipedia:Mesonephric_duct", "ZFIN:curator", "https://github.com/obophenotype/uberon/issues/28" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000637" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "Anatomical structure consisting of either of a pair of longitudinal ducts which carry urine and in males, sperm, to the cloaca.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000082" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "The first-formed kidney duct, which drains the kidney of most anamniotes and becomes the ductus deferens of male amniotes. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-3, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000082" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.686", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "(...) in all craniates, the archinephric duct develops in embryogeny.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Mesonephric_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "UMLS:C0043204" . [] oboInOwl:hasDbXref "GOC:yaf", "Wikipedia:Wolffian_duct", "ZFA:0000546" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "Wolffian duct" . [] oboInOwl:hasDbXref "Wikipedia:Wolffian_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "Leydig's duct" . [] oboInOwl:hasDbXref "VHOG:0000082", "Wikipedia:Wolffian_duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "archinephric duct" . [] oboInOwl:hasDbXref "Wikipedia:Mesonephric_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003074 ; owl:annotatedTarget "ductus mesonephricus; ductus Wolffi" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget obo:UBERON_0000483 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget _:genid126481 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget _:genid126483 . [] oboInOwl:hasDbXref "ISBN:0815318960", "OMD:neural+plate", "Wikipedia:Neural_plate", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000132" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000068" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Neural_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget "UMLS:C0920623" . [] oboInOwl:hasDbXref "Wikipedia:Neural_plate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003075 ; owl:annotatedTarget "lamina neuralis" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0003076 ; owl:annotatedTarget obo:UBERON_0003080 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001383" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003076 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . _:genid125490 a owl:Restriction ; owl:onProperty obo:BSPO_0000126, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000922, obo:UBERON_0007844 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget _:genid126498 . [] oboInOwl:hasDbXref "GO:0048339", "https://github.com/obophenotype/uberon/issues/30" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010568" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000114" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" . [] oboInOwl:source "ncithesaurus:Paraxial_Mesoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "UMLS:C1284009" . [] oboInOwl:hasDbXref "ZFA:0000255", "https://github.com/obophenotype/uberon/issues/30", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "paraxial mesenchyme" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15903 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[a2122h-1b_1-5]/1/" . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "somitic mesoderm" . [] oboInOwl:hasDbXref "Wikipedia:Paraxial_mesoderm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003077 ; owl:annotatedTarget "mesoderma paraxiale" . [] oboInOwl:source "NCBIBook:NBK53175", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget obo:UBERON_0009955 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget _:genid126509 . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget _:genid126512 . [] oboInOwl:hasDbXref "VHOG:0000117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000117" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. [Graham_A, The_development_and_evolution_of_the_pharyngeal_arches._J_Anat_(2001)_199:_133-141][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000117" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A, The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "Epibranchial placodes-derived neurons innervate internal organs to transmit information such as heart rate, blood pressure, and visceral distension from the periphery to the central nervous system (Baker and Bronner-Fraser, 2001). From rostral to caudal the epibranchial placodes comprise the geniculate, petrosal, and nodose placodes, each associated in sequence with the first, second and third branchial clefts. Each placode contributes sensory neurons to cranial nerves VII (facial nerve), IX (glossopharyngeal nerve), and X (vagal nerve), respectively" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group" . [] oboInOwl:hasDbXref "ZFA:0001294" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "epibranchial placodes" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003078 ; owl:annotatedTarget "ventrolateral placode" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001384" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003080 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2", "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget _:genid126527 . [] oboInOwl:source "EHDAA2", "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget _:genid126529 . [] oboInOwl:hasDbXref "MP:0010117", "Wikipedia:Lateral_plate_mesoderm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010574" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000118" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000118" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "subclass of mesoderm in ZFA." . [] oboInOwl:source "ncithesaurus:Lateral_Mesoderm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "UMLS:C1517749" . [] oboInOwl:hasDbXref "ZFA:0000121" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "LPM" . [] oboInOwl:hasDbXref "GO:0048368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "lateral mesoderm" . [] oboInOwl:hasDbXref "EHDAA2:0000919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "lateral plate mesenchyme" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plate_mesoderm" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003081 ; owl:annotatedTarget "mesoderma laminae lateralis" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget obo:UBERON_0017650 . [] oboInOwl:source "WP", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget _:genid126543 . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget _:genid126545 . [] oboInOwl:hasDbXref "AEO:0001018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." . _:genid125537 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001056" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0002521 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001244" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" . _:genid125539 oboInOwl:source "ncithesaurus:Myotome_Region" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "UMLS:C1513802" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004237 . [] oboInOwl:hasDbXref "TAO:0001056" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "myomeres" . [] oboInOwl:hasDbXref "Wikipedia:Myotome" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003082 ; owl:annotatedTarget "myotomus" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003083 ; owl:annotatedTarget _:genid126555 . [] oboInOwl:hasDbXref "ISBN:0815318960", "Wikipedia:Trunk_neural_crest" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003083 ; owl:annotatedTarget "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010582" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003083 ; owl:annotatedTarget "Post-cranial portion of the neural crest. Exact anatomical derivations not experimentally resolved in amphibians.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000062" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003083 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . _:genid125547 oboInOwl:hasDbXref "XAO:0000319" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003083 ; owl:annotatedTarget "TNC" ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0002522 . _:genid125549 oboInOwl:source "Obol" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget obo:UBERON_0001048 ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0010161 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget _:genid126562 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget _:genid126564 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget _:genid126567 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000028" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011044" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000028" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO]" . [] oboInOwl:source "ncithesaurus:Primordium_of_the_Heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "UMLS:C1514450" . [] oboInOwl:hasDbXref "ZFA:0000028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003084 ; owl:annotatedTarget "cardiac field" . [] oboInOwl:hasDbXref "Wikipedia:Caudal_artery", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003086 ; owl:annotatedTarget "Extension of the dorsal aorta in the tail." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000011" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003086 ; owl:annotatedTarget "Extension of the dorsal aorta in the tail. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011023" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-226-55763-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003086 ; owl:annotatedTarget "The posterior extension of the dorsal aorta to the tail region, which degenerates at metamorphosis.[AAO]" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget obo:UBERON_0005856 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget obo:UBERON_0007530 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget _:genid126587 . [] oboInOwl:hasDbXref "Wikipedia:Sclerotome", "XB:curator", "https://github.com/obophenotype/uberon/issues/316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010571" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "Skeletogenic portion of somites.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000680" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "part_of somite in XAO" . [] oboInOwl:source "ncithesaurus:Sclerotome" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "UMLS:C0183176" . [] oboInOwl:hasDbXref "TAO:0001080" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "sclerotomes" . [] oboInOwl:hasDbXref "Wikipedia:Sclerotome" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003089 ; owl:annotatedTarget "sclerotomus" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget _:genid126597 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget _:genid126599 . [] oboInOwl:source "ISBN:0073040584", "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget _:genid126601 . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/845125-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." . [] oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "Portion of tissue part of the pharyngeal endoderm that is fated to become thyroid follicle[ZFIN:curator]." . [] oboInOwl:source "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "In all vertebrates the thyroid arises from the ventral aspect of the second pouch" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "Note that we follow EHDAA2 in dividing this into endoderm and mesenchyme. In this ontology we place the broad developmental relationship at this level, and include specific relationships to the pharyngeal endoderm at the level of the endoderm" . [] oboInOwl:source "ncithesaurus:Thyroid_Primordium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "UMLS:C1519512" . [] oboInOwl:hasDbXref "ZFA:0001081" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003091 ; owl:annotatedTarget "thyroid primordia" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget obo:UBERON_0034705 . [] oboInOwl:hasDbXref "ISBN:0-914294-08-3", "MP:0004268" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000223" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/optic+stalk" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "The evagination from the neural tube of the developing embryo which develops the optic cup at its extremity; the stalk persists as the optic nerve. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000223" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Optic_Stalk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "UMLS:C0231107" . [] oboInOwl:hasDbXref "ZFA:0000137" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "optic stalks" . [] oboInOwl:hasDbXref "Wikipedia:Optic_stalk" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003098 ; owl:annotatedTarget "pedunculus opticus" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010580" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001194" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "Neural crest that is part of the head.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000063" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "XAO:0001001" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "CNC" . [] oboInOwl:hasDbXref "EMAPA:16091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "cephalic neural crest" . [] oboInOwl:hasDbXref "Wikipedia:Cranial_neural_crest" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003099 ; owl:annotatedTarget "crista neuralis cranialis" . [] oboInOwl:hasDbXref "CARO:0000028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003100 ; owl:annotatedTarget "Gonochoristic organism that can produce female gametes." . [] oboInOwl:hasDbXref "FMA:67812" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003100 ; owl:annotatedTarget "female human body" . [] oboInOwl:hasDbXref "TAO:0000303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003100 ; owl:annotatedTarget "female" . [] oboInOwl:hasDbXref "CARO:0000027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003101 ; owl:annotatedTarget "Gonochoristic organism that can produce male gametes." . [] oboInOwl:hasDbXref "FMA:67811" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003101 ; owl:annotatedTarget "male human body" . [] oboInOwl:hasDbXref "TAO:0000242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003101 ; owl:annotatedTarget "male" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/24" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003102 ; owl:annotatedTarget "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000292" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003102 ; owl:annotatedTarget "Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA]" . [] oboInOwl:hasDbXref "EHDAA2:0003010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003102 ; owl:annotatedTarget "anatomical surface feature" . [] oboInOwl:hasDbXref "ZFA:0000292" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003102 ; owl:annotatedTarget "surface structures" . [] oboInOwl:hasDbXref "CARO:0000024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003103 ; owl:annotatedTarget "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." . (obo:UBERON_0000479 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:CL_0008019 ] ) . ( ) . _:genid125624 oboInOwl:hasDbXref "https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up", "https://en.wikipedia.org/wiki/Mesenchyme", "https://github.com/obophenotype/uberon/issues/1641" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003104 ; owl:annotatedTarget "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000393" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003104 ; owl:annotatedTarget "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010427" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003104 ; owl:annotatedTarget "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" . [] oboInOwl:source "ncithesaurus:Mesenchyme" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003104 ; owl:annotatedTarget "UMLS:C0162415" . [] oboInOwl:hasDbXref "Wikipedia:Mesenchyme" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003104 ; owl:annotatedTarget "mesenchyma" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget obo:UBERON_0011004 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget _:genid126650 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget _:genid126652 . [] oboInOwl:hasDbXref "PMID:3693112", "Wikipedia:Meckel's_cartilage" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "Meckel's cartilage is the bilaterally paired, rod-like, cartilaginous ventral component of the lower jar, or ventral mandibular arch. It is typically resorbed in adults." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000289" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "Paired, rod-shaped elements that extend the length of the mandible and lie between the dentaries and the angulosplenials. Can be reduced to various extent in adults.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001205" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "Pharyngeal arch cartilage that is the cartilaginous embryonic component of the lower jaw, or ventral mandibular arch. It develops into the endochondral articular and retroarticular bones. Meckel's cartilage is paired.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000249" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.16-17", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "In all jawed vertebrates, including fish, the first pharyngeal arch generates the jaw apparatus. The neural crest cells of this arch migrate to form Meckel's cartilage, the precursor of the jaw.[well established][VHOG]" . _:genid125637 oboInOwl:source "http://www.briancoad.com" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "functional lower jaw of Elasmobranchii and Holocephali, the embryonic lower jaw of other gnathostomous vertebrates" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012140 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "cartilago arcus pharyngei primi" . [] oboInOwl:hasDbXref "http://www.briancoad.com" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "primary mandinle" . [] oboInOwl:hasDbXref "ZFA:0001205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003107 ; owl:annotatedTarget "ventral mandibular cartilage" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000189" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003110 ; owl:annotatedTarget "Anatomical cluster that is a posterolateral part of the cranium and structurally supports the vestibuloauditory system.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010208" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003110 ; owl:annotatedTarget "Anatomical cluster that is a posterolateral part of the neurocranium and structurally supports the vestibuloauditory system.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000189" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003110 ; owl:annotatedTarget "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003110 ; owl:annotatedTarget "cranial vault" . [] oboInOwl:hasDbXref "TAO:0000290", "UBERONREF:0000007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003111 ; owl:annotatedTarget "Anatomical cluster that forms the floor and sidewalls of the middle part of the cranium." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010207" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003111 ; owl:annotatedTarget "Anatomical cluster that forms the floor and sidewalls of the middle part of the neurocranium.[AAO]" . [] oboInOwl:hasDbXref "TAO:0000351" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003112 ; owl:annotatedTarget "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000351" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003112 ; owl:annotatedTarget "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the peripheral olfactory organ.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010206" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003112 ; owl:annotatedTarget "Anatomical cluster that is located in the anterior region of the neurocranium and provides structural support for the olfactory organs.[AAO]" . [] oboInOwl:hasDbXref "ZFA:0000351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003112 ; owl:annotatedTarget "ethmoid region" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget _:genid126679 . [] oboInOwl:hasDbXref "Wikipedia:Skull_roof", "ZFA:0000863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000558 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000863" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium and composed of dermally derived bones.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010154" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium which consists of dermally derived bones.[AAO]" . [] oboInOwl:hasDbXref "TAO:0000863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "dendrocranium" . [] oboInOwl:hasDbXref "UBERONREF:0000007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "exocranium" . [] oboInOwl:hasDbXref "PMID:11523816", "Wikipedia:Skull_roof" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "dermal skull roof" . [] oboInOwl:hasDbXref "Wikipedia:Skull_roof" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "roof of skull" . [] oboInOwl:hasDbXref "PMID:11523816", "Wikipedia:Skull_roof" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "skull roof" . [] oboInOwl:hasDbXref "ZFA:0000863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "dermal bone cranium" . [] oboInOwl:hasDbXref "Wikipedia:Skull_roof" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003113 ; owl:annotatedTarget "roofing bones of the skull" . [] oboInOwl:hasDbXref "MP:0006339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000558 ; owl:annotatedTarget "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010365" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "The most anterior, or first, pharygeal/branchial arch, composed of the mandibular process, forming the posterior border of the stomodeum, and the maxillary process anterior to the stomodeum, contains the first aortic arch.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000298" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "in XAO, called branchial arch 1 and df VP3" . [] oboInOwl:hasDbXref "ZFA:0001606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "first gill arch" . [] oboInOwl:hasDbXref "ZFA:0001606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "gill arch 1" . [] oboInOwl:hasDbXref "EHDAA2:0000069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "3rd arch" . [] oboInOwl:hasDbXref "VHOG:0000298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "3rd visceral arch" . [] oboInOwl:hasDbXref "AAO:0010365", "ZFA:0001606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "branchial arch 1" . [] oboInOwl:hasDbXref "ZFA:0001606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003114 ; owl:annotatedTarget "first branchial arch" . [] oboInOwl:hasDbXref "MP:0006340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010366" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "The second pharyngeal/branchial arch; arises as a thickening of the pharygeal wall between the first and second branchial clefts; contains the second aortic arch; forms part of the hyoid bone, tongue and facial musculature.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000299" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "in XAO, called branchial arch 2 and df VP4" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "4th branchial arch" . [] oboInOwl:hasDbXref "ZFA:0001607" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "gill arch 2" . [] oboInOwl:hasDbXref "ZFA:0001607" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "second gill arch" . [] oboInOwl:hasDbXref "EHDAA2:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "4th arch" . [] oboInOwl:hasDbXref "AAO:0010366", "ZFA:0001607" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "branchial arch 2" . [] oboInOwl:hasDbXref "VHOG:0000299" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "fourth visceral arch" . [] oboInOwl:hasDbXref "ZFA:0001607" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003115 ; owl:annotatedTarget "second branchial arch" . _:genid125690 oboInOwl:hasDbXref "MP:0006347" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001943 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010368" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "The forth in a series of paired bars in the wall of the pharynx, within which are formed the forth aortic arch and the cartilage bar of the visceral skeleton, forms and supports the gills.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001205" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0004075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "6th arch" . [] oboInOwl:hasDbXref "ZFA:0001609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "gill arch 4" . [] oboInOwl:hasDbXref "ZFA:0001609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "visceral arch 6" . [] oboInOwl:hasDbXref "VHOG:0001205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "6th pharyngeal arch" . [] oboInOwl:hasDbXref "VHOG:0001205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "6th visceral arch" . [] oboInOwl:hasDbXref "AAO:0010368", "ZFA:0001609" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "branchial arch 4" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "fourth branchial arch" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15904 ; owl:annotatedTarget "Long-chain fatty acid" . [] oboInOwl:hasDbXref "VHOG:0001205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "sixth pharyngeal arch" . [] oboInOwl:hasDbXref "XAO:0000453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003117 ; owl:annotatedTarget "sixth visceral arch" . _:genid125706 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001896, obo:UBERON_0004362 . [] oboInOwl:hasDbXref "MP:0010355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "The vessels formed within the first pair of branchial arches in embryogenesis." . _:genid125708 oboInOwl:external_ontology "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "ZFA states that The paired aortic arch 1 arteries branch off of the ventral aorta, and empty into the right and left lateral dorsal aortas" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002707 . [] oboInOwl:hasDbXref "EMAPA:16685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "1st arch artery" . [] oboInOwl:hasDbXref "ZFA:0005005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "AA1" . [] oboInOwl:hasDbXref "ZFA:0005005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "aortic arch 1" . [] oboInOwl:hasDbXref "XAO:0000342" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "first aortic arch" . [] oboInOwl:hasDbXref "ZFA:0005005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "mandibular aortic arch" . [] oboInOwl:hasDbXref "EMAPA:16685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "1st aortic arch artery" . [] oboInOwl:hasDbXref "EMAPA:16685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "1st branchial arch artery" . [] oboInOwl:hasDbXref "EMAPA:16685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "1st pharyngeal arch artery" . [] oboInOwl:hasDbXref "EMAPA:16685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003118 ; owl:annotatedTarget "first arch artery" . [] oboInOwl:hasDbXref "MP:0010356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "The vessels formed within the second pair of branchial arches in embryogenesis." . [] oboInOwl:source "Wikipedia:Aortic_arches#Arches_1_and_2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "The first and second arches disappear early, but the dorsal end of the second gives origin to the stapedial artery, a vessel which atrophies in humans but persists in some mammals. It passes through the ring of the stapes and divides into supraorbital, infraorbital, and mandibular branches which follow the three divisions of the trigeminal nerve. The infraorbital and mandibular arise from a common stem, the terminal part of which anastomoses with the external carotid. On the obliteration of the stapedial artery this anastomosis enlarges and forms the internal maxillary artery, and the branches of the stapedial artery are now branches of this vessel. The common stem of the infraorbital and mandibular branches passes between the two roots of the auriculotemporal nerve and becomes the middle meningeal artery; the original supraorbital branch of the stapedial is represented by the orbital twigs of the middle meningeal[WP][Wikipedia:Aortic_arches#Arches_1_and_2]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010418" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "The second in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 2 that is part of hyoid arch.[AAO]" . [] oboInOwl:hasDbXref "EHDAA2:0000051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "2nd arch artery" . [] oboInOwl:hasDbXref "ZFA:0005006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "AA2" . [] oboInOwl:hasDbXref "ZFA:0005006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "aortic arch 2" . [] oboInOwl:hasDbXref "ZFA:0005006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "hyoid aortic arch" . [] oboInOwl:hasDbXref "XAO:0000343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "second aortic arch" . [] oboInOwl:hasDbXref "EMAPA:16686" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "2nd aortic arch artery" . [] oboInOwl:hasDbXref "EMAPA:16686" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "2nd branchial arch artery" . _:genid125733 oboInOwl:hasDbXref "EMAPA:16686" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003119 ; owl:annotatedTarget "2nd pharyngeal arch artery" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 . [] oboInOwl:hasDbXref "MP:0006356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "The vessels formed within the third pair of branchial arches in embryogenesis." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005007" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO]" . [] oboInOwl:source "Wikipedia:Aortic_arches#Arch_3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "The third aortic arch constitutes the commencement of the internal carotid artery, and is therefore named the carotid arch[WP][Wikipedia:Aortic_arches#Arch_3]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010419" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "The third in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 3 lies within the 3rd branchial arch and branches directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO]" . [] oboInOwl:hasDbXref "EHDAA2:0000070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "3rd arch artery" . [] oboInOwl:hasDbXref "ZFA:0005007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "AA3" . [] oboInOwl:hasDbXref "ZFA:0005007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "aortic arch 3" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_arches#Arch_3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "carotid arch" . [] oboInOwl:hasDbXref "XAO:0000344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "third aortic arch" . [] oboInOwl:hasDbXref "EMAPA:16687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "3rd aortic arch artery" . [] oboInOwl:hasDbXref "EMAPA:16687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "3rd branchial arch artery" . [] oboInOwl:hasDbXref "EMAPA:16687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003120 ; owl:annotatedTarget "3rd pharyngeal arch artery" . [] oboInOwl:hasDbXref "MP:0006354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "The vessels formed within the fourth pair of branchial arches in embryogenesis." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005008" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010420" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "The forth in a series paired arterial connections between the dorsal and ventral aortae, lies within the 4th branchial arch. The paired aortic arch 4 arteries branch directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO]" . [] oboInOwl:source "Wikipedia:Aortic_arches#Arch_4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]." . [] oboInOwl:hasDbXref "EHDAA2:0000087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "4th arch artery" . [] oboInOwl:hasDbXref "ZFA:0005008" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "AA4" . [] oboInOwl:hasDbXref "ZFA:0005008" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "aortic arch 4" . [] oboInOwl:hasDbXref "XAO:0000355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "fourth aortic arch" . [] oboInOwl:hasDbXref "EMAPA:17004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "4th aortic arch artery" . _:genid125764 oboInOwl:hasDbXref "EMAPA:17004" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "4th branchial arch artery" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002743 . [] oboInOwl:hasDbXref "EMAPA:17004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "4th pharyngeal arch artery" . [] oboInOwl:hasDbXref "ISBN:0073040584", "XAO:0000355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003121 ; owl:annotatedTarget "systemic arch" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000559 ; owl:annotatedTarget obo:CL_0002194 . [] oboInOwl:hasDbXref "MP:0006355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "The vessels formed within the sixth pair of branchial arches in embryogenesis." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005016" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "The fifth and sixth arches, which come on-line at approximately 2.5 dpf, have a common trunk from the ventral aorta and drain to the midline dorsal aorta via an independent route. The fifth and sixth aortic arches supply the trunk and tail with oxigenated blood. Isogai et al. 2001.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010422" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-02-377110-0" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "The sixth in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 6 artery is paired and has a common trunk with aortic arch 5 from the ventral aorta, and drains via a separate branch of the lateral dorsal aorta. It forms part of the pulmonary arteries, and in the later embryo, the ductus arteriosis. Aortic arches 5 and 6 together supply the trunk and tail with oxygenated blood.[AAO]" . [] oboInOwl:source "Wikipedia:Aortic_arches#Arch_6" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "The sixth right arch disappears; the sixth left arch gives off the pulmonary arteries and forms the ductus arteriosus; this duct remains pervious during the whole of fetal life, but then closes within the first few days after birth due to increased O2 concentration. Oxygen concentration causes the production of bradykinin which causes the ductus to constrict occluding all flow. Within 1-3 months, the ductus is obliterated and becomes the ligamentum arteriosus. His showed that in the early embryo the right and left arches each gives a branch to the lungs, but that later both pulmonary arteries take origin from the left arch[WP][Wikipedia:Aortic_arches#Arch_6]." . _:genid125775 oboInOwl:source "http://emedicine.medscape.com/article/899609-overview" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "the distal left sixth arch becomes the ductus arteriosus, the proximal sixth arches bilaterally contribute to the proximal branch pulmonary arteries" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001896 . [] oboInOwl:hasDbXref "EMAPA:17005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "6th arch artery" . _:genid125777 oboInOwl:hasDbXref "ZFA:0005016" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "AA6" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004681 . [] oboInOwl:hasDbXref "ZFA:0005016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "aortic arch 6" . [] oboInOwl:hasDbXref "XAO:0000353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "sixth aortic arch" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000559 ; owl:annotatedTarget "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." . [] oboInOwl:hasDbXref "EMAPA:17005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "6th aortic arch artery" . [] oboInOwl:hasDbXref "EMAPA:17005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "6th branchial arch artery" . [] oboInOwl:hasDbXref "EMAPA:17005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "6th pharyngeal arch artery" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003123 ; owl:annotatedTarget "pulmonary arch" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget _:genid126809 . [] oboInOwl:hasDbXref "MESH:A10.615.284.473", "MP:0002836", "http://orcid.org/0000-0002-6601-2165", "https://github.com/geneontology/go-ontology/issues/22603" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "The outermost extraembryonic membrane of amniotes." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000200" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/chorion" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG]" . [] oboInOwl:source "BTO:0000252" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000200" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" . [] oboInOwl:source "PMID:19829370" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "Extra-embryonic ectoderm" . [] oboInOwl:source "ncithesaurus:Chorion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "UMLS:C0008503" . [] oboInOwl:source "ncithesaurus:Chorionic_Sac" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "UMLS:C1516505" . [] oboInOwl:hasDbXref "ZFIN:curator", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "uterine chorion" . [] oboInOwl:hasDbXref "Wikipedia:Chorion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "chorion frondosum" . _:genid125797 oboInOwl:hasDbXref "Wikipedia:Chorion" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003124 ; owl:annotatedTarget "chorionic sac" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15904 ; owl:annotatedTarget "Higher fatty acid" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget _:genid126824 . [] oboInOwl:hasDbXref "GO:0060438", "Wikipedia:Vertebrate_trachea" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010140" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "An elongated tube which carries air to and from the lungs.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000371" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000371" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.409", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG]" . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "in mouse 15-18 C-rings, 15-20 in human." . [] oboInOwl:source "ncithesaurus:Trachea" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "UMLS:C0040578" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "vertebrate trachea" . [] oboInOwl:hasDbXref "BTO:0001388" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003126 ; owl:annotatedTarget "tracheal tubule" . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D025042", "WikipediaVersioned:Amacrine_cell&oldid=1023572246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000561 ; owl:annotatedTarget "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." . [] oboInOwl:source "FMA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:hasDbXref "Wikipedia:Cranium_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "Upper portion of the skull that excludes the mandible (when present in the organism)." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton" . [] oboInOwl:hasDbXref "FMA:71325" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "bones of cranium" . [] oboInOwl:hasDbXref "FMA:71325", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "ossa cranii" . [] oboInOwl:hasDbXref "FMA:71325" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "set of bones of cranium" . [] oboInOwl:hasDbXref "BTO:0001328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003128 ; owl:annotatedTarget "calvarium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003129 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:hasDbXref "PMID:11523816", "Wikipedia:Skull", "http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003129 ; owl:annotatedTarget "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003129 ; owl:annotatedTarget "in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible." . _:genid125826 oboInOwl:source "WP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0003129 ; owl:annotatedTarget "A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 . [] oboInOwl:source "ncithesaurus:Skull" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003129 ; owl:annotatedTarget "UMLS:C0037303" . [] oboInOwl:hasDbXref "UBERON:xp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003133 ; owl:annotatedTarget "An organ involved in reproduction." . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003133 ; owl:annotatedTarget "GO uses genitalia for the singular organ" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003133 ; owl:annotatedTarget "EMAPA:37731" . [] oboInOwl:source "ncithesaurus:Genitalia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003133 ; owl:annotatedTarget "UMLS:C0017420" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003133 ; owl:annotatedTarget "genitalia" . [] oboInOwl:hasDbXref "UBERON:xp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "A female organ involved in reproduction." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "female organism reproductive organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "female organism reproductive structure" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "female organism reproductive system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "female organism sex organ" . [] oboInOwl:hasDbXref "MA:0000544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "female reproductive gland/organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "reproductive organ of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "reproductive structure of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "reproductive system organ of female organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003134 ; owl:annotatedTarget "sex organ of female organism" . [] oboInOwl:hasDbXref "UBERON:xp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "A male organ involved in reproduction." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male organism reproductive organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male organism reproductive structure" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male organism reproductive system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male organism sex organ" . [] oboInOwl:hasDbXref "MA:0000545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male reproductive gland/organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "reproductive organ of male organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "reproductive structure of male organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "reproductive system organ of male organism" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "sex organ of male organism" . [] oboInOwl:hasDbXref "WBbt:0008423" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003135 ; owl:annotatedTarget "male genital" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000562 ; owl:annotatedTarget obo:CL_0000232 . [] oboInOwl:hasDbXref "FBC:auto_generated_definition" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "gustatory organ system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "gustatory system organ" . _:genid125877 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "organ of gustatory organ system" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004714 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "organ of gustatory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "organ of taste system" . [] oboInOwl:hasDbXref "GOC:add", "GOc:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000562 ; owl:annotatedTarget "An erythrocyte having a nucleus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003212 ; owl:annotatedTarget "taste system organ" . [] oboInOwl:hasDbXref "GO:0060749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "A sac-like structure that is found in the mature gland[GO]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "alveolus of lactiferous gland" . _:genid125889 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "alveolus of lobe of breast" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001890 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "alveolus of lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "alveolus of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "lobe of breast alveolus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "lobe of mammary gland alveolus" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003214 ; owl:annotatedTarget "mammary alveoli" . [] oboInOwl:hasDbXref "Wikipedia:Alveolus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003215 ; owl:annotatedTarget "Organ part that has the form of a hollow cavity[WP]." . [] oboInOwl:source "ncithesaurus:Alveolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003215 ; owl:annotatedTarget "UMLS:C0034051" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget obo:UBERON_0034921 . [] oboInOwl:notes "check this" ; oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget _:genid126923 . [] oboInOwl:hasDbXref "GO:0060022", "Wikipedia:Hard_palate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget "Anterior portion of the palate consisting of bone and mucous membranes [GO]. The hard palate is formed from bony processes of the maxilla, premaxilla and palatine bone [Kardong]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15904 ; owl:annotatedTarget "LCFA" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget "in FMA this is divided into bony parts and submucosa" . [] oboInOwl:source "ncithesaurus:Hard_Palate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget "UMLS:C0226901" . [] oboInOwl:hasDbXref "Wikipedia:Hard_palate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003216 ; owl:annotatedTarget "palatum durum" . ( ) . [] oboInOwl:hasDbXref "GO:0080126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003218 ; owl:annotatedTarget "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget _:genid126940 . [] oboInOwl:hasDbXref "GO:0072075", "Wikipedia:Metanephric_blastema" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000540" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/metanephric+mesenchyme" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "A mass of intermediate mesodermal cells around the distal end of the ureteric bud that gives rise to nephrons in the metanephric kidney. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000540" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.462", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "When the ureteric buds emerge from the nephric duct, they enter the metanephrogenic mesenchyme. The ureteric buds induce this mesenchymal tissue to condense around them and differentiate into the nephrons of the mammalian kidney. As this mesenchyme differentiates, it tells the ureteric bud to branch and grow.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Metanephric_blastema" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "metanephric blastema" . [] oboInOwl:hasDbXref "Wikipedia:Metanephric_blastema" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "metanephric mesoderm" . [] oboInOwl:hasDbXref "EHDAA:5021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "metanephrogenic mesenchyme" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0001139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003220 ; owl:annotatedTarget "metanephros associated mesenchyme" . [] oboInOwl:hasDbXref "VSAO:0000199", "Wikipedia:Phalanx_bones" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three" . [] oboInOwl:source "ncithesaurus:Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "UMLS:C0222682" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "long bone of digit" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "phalanges" . [] oboInOwl:hasDbXref "Wikipedia:Phalanx_bones" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003221 ; owl:annotatedTarget "phalanx bone" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget _:genid126966 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "An epithelium that is part of a elbow [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "cubital region epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "cubital region epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "elbow epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "elbow epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "epithelial tissue of cubital region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "epithelial tissue of elbow" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003229 ; owl:annotatedTarget "epithelium of cubital region" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget _:genid126981 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "An epithelium that is part of a wrist [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "carpal region epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "carpal region epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "epithelial tissue of carpal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "epithelial tissue of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "epithelium of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "wrist epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003230 ; owl:annotatedTarget "wrist epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget _:genid126995 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "An epithelium that is part of a hip [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "epithelial tissue of hip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "epithelial tissue of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "epithelial tissue of regio coxae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "epithelium of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "epithelium of regio coxae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "hip epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "hip epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "hip region epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "hip region epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "regio coxae epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003231 ; owl:annotatedTarget "regio coxae epithelium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000566 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003232 ; owl:annotatedTarget _:genid127013 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003232 ; owl:annotatedTarget "An epithelium that is part of a knee [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003232 ; owl:annotatedTarget "epithelial tissue of knee" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003232 ; owl:annotatedTarget "knee epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003232 ; owl:annotatedTarget "knee epithelium" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:12768659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000566 ; owl:annotatedTarget "A mesenchymal stem cell capable of developing into blood vessel endothelium." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003233 ; owl:annotatedTarget _:genid127023 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003233 ; owl:annotatedTarget "An epithelium that is part of a shoulder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003233 ; owl:annotatedTarget "epithelial tissue of shoulder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003233 ; owl:annotatedTarget "shoulder epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003233 ; owl:annotatedTarget "shoulder epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15904 ; owl:annotatedTarget "LCFAs" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "MESH:A11.070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000568 ; owl:annotatedTarget "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "An epithelium that is part of a upper jaw [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "epithelial tissue of palatoquadrate arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "epithelial tissue of upper jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "epithelium of palatoquadrate arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "palatoquadrate arch epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "palatoquadrate arch epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "upper jaw epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003235 ; owl:annotatedTarget "upper jaw epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "An epithelium that is part of a lower jaw [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "epithelial tissue of lower jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "epithelial tissue of ventral mandibular arch" . _:genid126016 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "epithelium of ventral mandibular arch" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002105 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "lower jaw epithelial tissue" . _:genid126018 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "lower jaw epithelium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003249 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "ventral mandibular arch epithelial tissue" . _:genid126020 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003236 ; owl:annotatedTarget "ventral mandibular arch epithelium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005565 . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001855 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "Reissner's canal epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "Reissner's canal epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "cochlear duct epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "cochlear duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "cochlear duct of membranous labyrinth epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "cochlear duct of membranous labyrinth epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "epithelial tissue of Reissner's canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "epithelial tissue of cochlear duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "epithelial tissue of cochlear duct of membranous labyrinth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "epithelium of Reissner's canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003243 ; owl:annotatedTarget "epithelium of cochlear duct of membranous labyrinth" . [] oboInOwl:source "EHDAA2", "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget _:genid127073 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "The epithelial layer of the luminal surfaces of the mammary gland." . [] oboInOwl:source "ncithesaurus:Mammary_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "UMLS:C0596882" . [] oboInOwl:hasDbXref "FMA:74445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "epithelium of lactiferous gland" . [] oboInOwl:hasDbXref "FMA:74445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "lactiferous gland epithelium" . [] oboInOwl:hasDbXref "BTO:0001430" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "mammary epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "mammary gland epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003244 ; owl:annotatedTarget "mammary gland epithelium" . [] oboInOwl:hasDbXref "PMID:18816864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000569 ; owl:annotatedTarget "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003247 ; owl:annotatedTarget _:genid127087 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003247 ; owl:annotatedTarget "An epithelium that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003248 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003248 ; owl:annotatedTarget _:genid127095 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003248 ; owl:annotatedTarget "An epithelium that is part of a footplate." . [] oboInOwl:hasDbXref "EHDAA2:0000548" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003248 ; owl:annotatedTarget "footplate epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003249 ; owl:annotatedTarget "An epithelium that is part of a otic placode [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003249 ; owl:annotatedTarget "epithelial tissue of otic placode" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003249 ; owl:annotatedTarget "otic epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003249 ; owl:annotatedTarget "otic placode epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003249 ; owl:annotatedTarget "otic placode epithelium" . _:genid126076 oboInOwl:notes "check other species" ; oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget _:genid127108 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "Subdivision of skeletal system that consists of all ribs in an organism connected to the sternum and the vertebrae. Some vertebrates have abdominal ribs (gastrialia), not connected to the vertebrate - these are not considered part of the rib case." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002100" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "Anatomical cluster that consists of more than one rib in an individual.[TAO]" . [] oboInOwl:hasDbXref "FMA:7480", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "cavea thoracis" . [] oboInOwl:hasDbXref "FMA:7480" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "rib cage" . [] oboInOwl:hasDbXref "FMA:7480" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "thoracic cage" . [] oboInOwl:hasDbXref "Wikipedia:Human_rib_cage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003252 ; owl:annotatedTarget "cavea thoracis" . [] oboInOwl:source "PMID:15906248" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget _:genid127123 . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_rib" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget "The neck of the rib is the flattened portion which extends lateralward from the head; it is about 2.5 cm. long, and is placed in front of the transverse process of the lower of the two vertebrC& with which the head articulates. Its anterior surface is flat and smooth, its posterior rough for the attachment of the ligament of the neck, and perforated by numerous foramina. Of its two borders the superior presents a rough crest (crista colli costE) for the attachment of the anterior costotransverse ligament; its inferior border is rounded. On the posterior surface at the junction of the neck and body, and nearer the lower than the upper border, is an eminencebthe tubercle; it consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrC& to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget "EMAPA:37826" . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_rib" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget "collum costae" . [] oboInOwl:hasDbXref "FMA:7576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget "rib neck" . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_rib" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003253 ; owl:annotatedTarget "collum costae" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget _:genid127132 . [] oboInOwl:source "EHDAA2-via-amnioblasts", "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget _:genid127134 . [] oboInOwl:hasDbXref "EHDAA2:0000117", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget "amnion ectoderm" . [] oboInOwl:hasDbXref "ISBN:9780878932504", "http://placentation.ucsd.edu/glossfs.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget "amnionic ectoderm" . [] oboInOwl:hasDbXref "BTO:0000897" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003254 ; owl:annotatedTarget "amnion epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15904 ; owl:annotatedTarget "long-chain fatty acids" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003257 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003257 ; owl:annotatedTarget "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003258 ; owl:annotatedTarget "An endoderm that is part of a foregut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003258 ; owl:annotatedTarget "foregut endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003259 ; owl:annotatedTarget "An endoderm that is part of a midgut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003259 ; owl:annotatedTarget "midgut endoderm" . _:genid126126 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000012, obo:UBERON_0001046 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003260 ; owl:annotatedTarget "An endoderm that is part of a hindgut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003260 ; owl:annotatedTarget "hindgut endoderm" . [] oboInOwl:source "ZFA-propagated" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003261 ; owl:annotatedTarget _:genid127175 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003261 ; owl:annotatedTarget "An endoderm that is part of a thyroid primordium." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003261 ; owl:annotatedTarget "endoderm of thyroid primordium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget _:genid127186 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "A mesenchyme that is part of a amnion." . [] oboInOwl:hasDbXref "EHDAA2:0000118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "amnion mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "amnion mesoderm" . [] oboInOwl:hasDbXref "http://placentation.ucsd.edu/glossfs.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "amnionic mesoderm" . [] oboInOwl:hasDbXref "EMAPA:16265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "mesenchyme of amnion" . [] oboInOwl:hasDbXref "EMAPA:16265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "amnionic mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:16111" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003262 ; owl:annotatedTarget "amnionic mesoderm" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget _:genid127201 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget _:genid127203 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget "A mesenchyme that is part of a chorion." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget "chorion mesenchyme" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0000247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget "chorion mesoderm" . [] oboInOwl:hasDbXref "EHDAA2:0003245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget "chorionic mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003265 ; owl:annotatedTarget "mesenchyme of chorion (vertebrates)" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003267 ; owl:annotatedTarget "A calcareous tooth that is part of the upper jaw region. In mammals, the upper jaw teeth are attached to the maxilla." . [] oboInOwl:source "ncithesaurus:Upper_Jaw_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003267 ; owl:annotatedTarget "UMLS:C1710581" . [] oboInOwl:hasDbXref "MA:0001909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003267 ; owl:annotatedTarget "upper jaw tooth" . [] oboInOwl:hasDbXref "NCBITaxon:40674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003267 ; owl:annotatedTarget "maxillary tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget obo:CL_0000443 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary)." . [] oboInOwl:source "ncithesaurus:Lower_Jaw_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "UMLS:C1708757" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "calcareous tooth of lower jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "lower jaw calcareous tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "lower jaw dentine containing tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "lower jaw tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "lower jaw vertebrate tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget obo:CL_0000710 . [] oboInOwl:hasDbXref "NCBITaxon:40674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003268 ; owl:annotatedTarget "mandibular tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003269 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003269 ; owl:annotatedTarget "eye skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003269 ; owl:annotatedTarget "eye skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003269 ; owl:annotatedTarget "skeletal muscle tissue of eye" . [] oboInOwl:hasDbXref "EHDAA2:0000486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003269 ; owl:annotatedTarget "eye skeletal muscle group" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003277 ; owl:annotatedTarget "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000429" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003277 ; owl:annotatedTarget "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003277 ; owl:annotatedTarget "EMAPA/MA placement unclear. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" . [] oboInOwl:hasDbXref "MA:0001908" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003277 ; owl:annotatedTarget "upper jaw" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "C cell of thyroid gland" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget _:genid127258 . [] oboInOwl:source "VHOG-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget _:genid127260 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001273" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000428" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "clear cell of thyroid gland" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" . [] oboInOwl:hasDbXref "MA:0001906", "ZFA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "lower jaw" . [] oboInOwl:hasDbXref "ZFA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "mandible" . [] oboInOwl:hasDbXref "AAO:0000274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "lower jaw skeleton" . [] oboInOwl:hasDbXref "TAO:0001273" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "mandibles" . [] oboInOwl:hasDbXref "ZFA:0001273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003278 ; owl:annotatedTarget "mandibular series" . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "parafollicular cell of thyroid gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003279 ; owl:annotatedTarget "An endothelium that is part of a trachea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003279 ; owl:annotatedTarget "endothelium of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003279 ; owl:annotatedTarget "trachea endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003279 ; owl:annotatedTarget "windpipe endothelium" . _:genid126239 oboInOwl:source "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget obo:UBERON_0004854 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "FMA:68653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000570 ; owl:annotatedTarget "thyroid parafollicular cell" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget _:genid127284 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/mesogastrium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000358" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mesogastrium" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. [TFD][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "mesentery of ventriculus" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/mesogastrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "mesogaster" . [] oboInOwl:hasDbXref "MA:0001617" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "mesogastium" . [] oboInOwl:hasDbXref "http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "mesogastrium" . [] oboInOwl:hasDbXref "Obol:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "stomach mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003281 ; owl:annotatedTarget "ventriculus mesentery" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003282 ; owl:annotatedTarget "A mesentery that surrounds the heart." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003282 ; owl:annotatedTarget "heart mesentery" . [] oboInOwl:hasDbXref "EMAPA:16212" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003282 ; owl:annotatedTarget "cardiac mesentery" . [] oboInOwl:hasDbXref "MA:0000098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003282 ; owl:annotatedTarget "mesocardium" . [] oboInOwl:hasDbXref "MESH:D017949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000573 ; owl:annotatedTarget "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "A mesentery that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000415" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "MA:0001569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "esophagus mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "gullet mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "mesentery of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "mesentery of gullet" . [] oboInOwl:hasDbXref "VHOG:0000415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003283 ; owl:annotatedTarget "oesophagus mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003284 ; owl:annotatedTarget "A mesentery that is part of a midgut [Automatically generated definition]." . _:genid126273 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000413" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003284 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003284 ; owl:annotatedTarget "midgut mesentery" . _:genid126275 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002360 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891 ] ) ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0009615 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "A meninx that is part of a midbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000012" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "Meninges that are part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000012" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "meninges of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "midbrain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "midbrain meninx" . [] oboInOwl:hasDbXref "VHOG:0000012" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003288 ; owl:annotatedTarget "mesencephalon meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "A meninx that is part of a telencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000010" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "Meninges that are part of the telencephalon. [Bgee_curator][VHOG]" . _:genid126292 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000010" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 . [] oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "meninges of telencephalon" . _:genid126294 oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "telencephalon meninges" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003289 ; owl:annotatedTarget "telencephalon meninx" . _:genid126296 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002360 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007383 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "A meninx that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000009" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "Meninges that are part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000009" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "between brain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "between brain meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "diencephalon meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "diencephalon meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "interbrain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "interbrain meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "mature diencephalon meninges" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000575 ; owl:annotatedTarget "An epithelial cell of the cornea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "mature diencephalon meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninges of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninges of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninges of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninges of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninx of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninx of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003290 ; owl:annotatedTarget "meninx of mature diencephalon" . [] oboInOwl:hasDbXref "FMA:70551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000575 ; owl:annotatedTarget "epithelial cell of cornea" . _:genid126320 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0002028, obo:UBERON_0007282 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget _:genid127368 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "A meninx that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000011" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "Meninges that are part of the hindbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000011" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "hindbrain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "hindbrain meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "meninges of hindbrain" . [] oboInOwl:hasDbXref "VHOG:0000011" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003291 ; owl:annotatedTarget "rhomencephalon meninges" . _:genid126330 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002360 _:genid126332 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 . _:genid126332 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002240, obo:UBERON_0005721 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "A meninx that is part of a spinal cord [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000443" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "Meninges that are part of the spinal cord. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000443" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Spinal_Meninges" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "UMLS:C0037938" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "menines of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "meninges of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "spinal cord meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "spinal cord meninx" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003292 ; owl:annotatedTarget "spinal meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003294 ; owl:annotatedTarget "A gland that is part of a foregut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003294 ; owl:annotatedTarget "foregut gland" . _:genid126353 oboInOwl:source "BTO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003295 ; owl:annotatedTarget _:genid127400 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003068 . [] oboInOwl:hasDbXref "http://www.biology-online.org/dictionary/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003295 ; owl:annotatedTarget "Racemose mucous glands beneath the mucous membrane of the pharynx." . _:genid126355 oboInOwl:hasDbXref "EHDAA2:0001461" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003295 ; owl:annotatedTarget "pharynx gland" ; owl:onProperty obo:RO_0002494 ; owl:someValuesFrom obo:UBERON_0034878 . [] oboInOwl:hasDbXref "BTO:0004849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003295 ; owl:annotatedTarget "glandulae pharyngeae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003296 ; owl:annotatedTarget "Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003296 ; owl:annotatedTarget "diencephalon gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003296 ; owl:annotatedTarget "interbrain gland" . _:genid126364 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002530 _:genid126366 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000926 . _:genid126366 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002416, obo:UBERON_0005256 . _:genid126368 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003297 ; owl:annotatedTarget "A gland that is part of a integumental system [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003297 ; owl:annotatedTarget "integumental gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003297 ; owl:annotatedTarget "integumental system gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003297 ; owl:annotatedTarget "integumentary gland" . [] oboInOwl:hasDbXref "MGI:anna", "MGI:smb", "MP:0006103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "The mesencephalic roof plate, including the caudal and rostral part of the midbrain roof." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000772" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "Roof plate that is part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "midbrain roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "midbrain roofplate" . [] oboInOwl:hasDbXref "VHOG:0000772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "roof plate midbrain" . [] oboInOwl:hasDbXref "ZFA:0000355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "roof plate midbrain region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "roofplate of midbrain" . [] oboInOwl:hasDbXref "EMAPA:16981" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "midbrain roof" . [] oboInOwl:hasDbXref "VHOG:0000772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "roof plate mesencephalon" . [] oboInOwl:hasDbXref "VHOG:0000772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003299 ; owl:annotatedTarget "roofplate midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "A roof plate that is part of a telencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000774" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "Roof plate that is part of the telencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000774" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "roof plate telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "roofplate of telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "telencephalon roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "telencephalon roofplate" . [] oboInOwl:hasDbXref "VHOG:0000774" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003300 ; owl:annotatedTarget "roofplate medulla telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "A roof plate that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000771" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "Roof plate that is part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "between brain roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "between brain roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "diencephalon roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "diencephalon roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "interbrain roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "interbrain roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "mature diencephalon roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "mature diencephalon roofplate" . [] oboInOwl:hasDbXref "ZFA:0001358" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roof plate diencephalic region" . [] oboInOwl:hasDbXref "VHOG:0000771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roof plate diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roof plate of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roof plate of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roof plate of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roofplate of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roofplate of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roofplate of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roofplate of mature diencephalon" . [] oboInOwl:hasDbXref "VHOG:0000771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003301 ; owl:annotatedTarget "roofplate medulla diencephalon" . _:genid126430 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001895, obo:UBERON_0003056 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "A roof plate that is part of a metencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000770" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "Roof plate that is part of the metencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "epencephalon-2 roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "epencephalon-2 roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "metencephalon roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "metencephalon roofplate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000576 ; owl:annotatedTarget obo:CL_0000766 . _:genid126440 oboInOwl:hasDbXref "VHOG:0000770" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "roof plate metencephalon" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010312 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "roof plate of epencephalon-2" . _:genid126442 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "roofplate of epencephalon-2" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004128 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "roofplate of metencephalon" . [] oboInOwl:hasDbXref "VHOG:0000770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003302 ; owl:annotatedTarget "roofplate medulla metencephalon" . [] oboInOwl:hasDbXref "GO_REF:0000031", "MESH:D009000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000576 ; owl:annotatedTarget "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "A roof plate that is part of a medulla oblongata [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000776" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "Roof plate that is part of the medulla oblongata. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "bulb roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "bulb roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "medulla oblongata roof plate" . _:genid126456 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "medulla oblongata roofplate" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010312 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "medulla oblonmgata roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "medulla oblonmgata roofplate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "metepencephalon roof plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "metepencephalon roofplate" . [] oboInOwl:hasDbXref "VHOG:0000776" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roof plate medulla oblongata" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roof plate of bulb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roof plate of medulla oblonmgata" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roof plate of metepencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roofplate of bulb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roofplate of medulla oblongata" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roofplate of medulla oblonmgata" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roofplate of metepencephalon" . _:genid126469 oboInOwl:hasDbXref "VHOG:0000776" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003303 ; owl:annotatedTarget "roofplate medulla oblongata" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005792 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000586 ; owl:annotatedTarget obo:CL_0000039 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget obo:UBERON_0007503 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget _:genid127523 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget _:genid127525 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget "A blood island that is part of a mesoderm." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget "in EHDAA2, gives rise to blood and dorsal aorta" . [] oboInOwl:hasDbXref "EHDAA2:0003241" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget "mesoderm blood islands" . [] oboInOwl:hasDbXref "MESH:D005854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000586 ; owl:annotatedTarget "The reproductive cell in multicellular organisms." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003304 ; owl:annotatedTarget "mesenchyme blood island" . _:genid126481 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003104 _:genid126483 ) ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0002328 . _:genid126483 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0000473, obo:UBERON_0007284 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003312 ; owl:annotatedTarget "Mesenchyme that is part of a developing testis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003312 ; owl:annotatedTarget "testis mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003314 ; owl:annotatedTarget _:genid127541 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003314 ; owl:annotatedTarget "Mesenchyme that is part of a developing camera-type eye." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003314 ; owl:annotatedTarget "mesenchyme of eye" . _:genid126498 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "Mesenchyme that is part of a developing ovary [Automatically generated definition]." ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007285 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "female reproductive system gonad mesenchyme" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "Beilstein:1720524" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "female reproductive system gonada mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "gonad of female reproductive system mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "gonada of female reproductive system mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "mesenchyme of female reproductive system gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "mesenchyme of female reproductive system gonada" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "mesenchyme of gonad of female reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "mesenchyme of gonada of female reproductive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003315 ; owl:annotatedTarget "ovary mesenchyme" . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001040 ] ) . _:genid126512 oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003316 ; owl:annotatedTarget "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003316 ; owl:annotatedTarget "yolk sac mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003317 ; owl:annotatedTarget "An odontogenic papilla that is part of a incisor tooth [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003317 ; owl:annotatedTarget "incisor dental papilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003317 ; owl:annotatedTarget "incisor odontogenic papilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003317 ; owl:annotatedTarget "incisor tooth odontogenic papilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003317 ; owl:annotatedTarget "odontogenic papilla of incisor tooth" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003318 ; owl:annotatedTarget "Mesenchyme that is part of a developing elbow [Automatically generated definition]." . _:genid126529 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003318 ; owl:annotatedTarget "cubital region mesenchyme" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000593 ; owl:annotatedTarget "A steroid hormone secreting cell that secretes androgen." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003318 ; owl:annotatedTarget "elbow mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003318 ; owl:annotatedTarget "mesenchyme of cubital region" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003319 ; owl:annotatedTarget "Mesenchyme of the carpal region that contributes to the carpal skeleton." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003319 ; owl:annotatedTarget "carpal region mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003319 ; owl:annotatedTarget "carpus mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003319 ; owl:annotatedTarget "mesenchyme of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003319 ; owl:annotatedTarget "wrist mesenchyme" . _:genid126543 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001464, obo:UBERON_0002329 . _:genid126545 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "Mesenchyme that is part of a developing hip [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004290 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "hip mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "hip region mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "mesenchyme of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "mesenchyme of regio coxae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003320 ; owl:annotatedTarget "regio coxae mesenchyme" . _:genid126555 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003321 ; owl:annotatedTarget "Mesenchyme that is part of a developing knee [Automatically generated definition]." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000011 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003321 ; owl:annotatedTarget "knee mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003322 ; owl:annotatedTarget "Mesenchyme that is part of a developing shoulder [Automatically generated definition]." . _:genid126562 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003322 ; owl:annotatedTarget "shoulder mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] ) . _:genid126567 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003323 ; owl:annotatedTarget _:genid127618 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007005 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003323 ; owl:annotatedTarget "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003323 ; owl:annotatedTarget "mesenchyme of palatoquadrate arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003323 ; owl:annotatedTarget "palatoquadrate arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003323 ; owl:annotatedTarget "upper jaw mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003324 ; owl:annotatedTarget _:genid127628 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003324 ; owl:annotatedTarget "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003324 ; owl:annotatedTarget "lower jaw mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003324 ; owl:annotatedTarget "mesenchyme of ventral mandibular arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003324 ; owl:annotatedTarget "ventral mandibular arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "Mesenchyme that is part of a developing pinna [Automatically generated definition]." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "EMAPA divides this spatially into condensation + rest, and temporally into mesenchyme and cartilage condensation" . _:genid126587 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "auricle mesenchyme" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002329 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "auricle of ear mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "auricle of external ear mesenchyme" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000595 ; owl:annotatedTarget obo:CL_0000232 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "auricula (auris externa) mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "auricula mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of auricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of auricle of ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of auricle of external ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of auricula" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of auricula (auris externa)" . _:genid126597 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "mesenchyme of pinna of ear" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000949 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "pinna mesenchyme" . _:genid126599 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003325 ; owl:annotatedTarget "pinna of ear mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "CAS:488-81-3" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000595 ; owl:annotatedTarget "An erythrocyte lacking a nucleus." . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001911 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "Mesenchyme that is part of a developing mammary gland." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "lactiferous gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "lobe of breast mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "lobe of mammary gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "mammary gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "mesenchyme of lactiferous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "mesenchyme of lobe of breast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003326 ; owl:annotatedTarget "mesenchyme of lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003327 ; owl:annotatedTarget "Mesenchyme that is part of a developing lower arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "MESH:D017948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000604 ; owl:annotatedTarget "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003328 ; owl:annotatedTarget _:genid127674 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003328 ; owl:annotatedTarget "Mesenchyme that is part of a footplate." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003328 ; owl:annotatedTarget "We group two EMAPA classes here but these may need to be separated" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "A submucosa that is part of an anal canal [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "anal canal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "anal canal viewed anatomically submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "anal region submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "anatomical anal canal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "submucosa of anal canal viewed anatomically" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "submucosa of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003329 ; owl:annotatedTarget "submucosa of anatomical anal canal" . [] oboInOwl:hasDbXref "BTO:0002114" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003330 ; owl:annotatedTarget "The submucous layer of the wall of the rectum." . [] oboInOwl:hasDbXref "FMA:15034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003330 ; owl:annotatedTarget "rectal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003330 ; owl:annotatedTarget "rectum submucosa" . [] oboInOwl:hasDbXref "BTO:0002114" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003330 ; owl:annotatedTarget "tela submucosa recti" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003331 ; owl:annotatedTarget "A submucosa that is part of a colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003331 ; owl:annotatedTarget "colon submucosa" . _:genid126650 oboInOwl:hasDbXref "FMA:14985" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003331 ; owl:annotatedTarget "colonic submucosa" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003278 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003331 ; owl:annotatedTarget "large bowel submucosa" . _:genid126652 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003331 ; owl:annotatedTarget "submucosa of large bowel" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003332 ; owl:annotatedTarget "A submucosa that is part of a duodenum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14943" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003332 ; owl:annotatedTarget "doudenal submucosa" . [] oboInOwl:hasDbXref "FMA:14943" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003332 ; owl:annotatedTarget "duodenal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003332 ; owl:annotatedTarget "duodenum submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003333 ; owl:annotatedTarget "A submucosa that is part of a jejunum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14950" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003333 ; owl:annotatedTarget "jejunal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003333 ; owl:annotatedTarget "jejunum submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "A serous membrane that is part of a rectum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:15039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "rectal serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "rectum serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "rectum serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "serous membrane of rectum" . [] oboInOwl:hasDbXref "FMA:15039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003334 ; owl:annotatedTarget "visceral peritoneum of rectum" . (obo:UBERON_0000042 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001155 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "A serous membrane that is part of a colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "colon serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "colon serous membrane" . [] oboInOwl:hasDbXref "FMA:14990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "colonic serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "large bowel serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "large bowel serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "serosa of large bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "serous membrane of colon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "serous membrane of large bowel" . [] oboInOwl:hasDbXref "FMA:14990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003335 ; owl:annotatedTarget "visceral peritoneum of colon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "A serous membrane that is part of a duodenum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "doudenal serosa" . [] oboInOwl:hasDbXref "FMA:14948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "duodenal serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "duodenum serosa" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "CAS:488-81-3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "duodenum serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "serous membrane of duodenum" . [] oboInOwl:hasDbXref "FMA:14948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003336 ; owl:annotatedTarget "visceral peritoneum of duodenum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "A serous membrane that is part of a jejunum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14955" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "jejunal serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "jejunum serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "jejunum serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "serous membrane of jejunum" . [] oboInOwl:hasDbXref "FMA:14955" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003337 ; owl:annotatedTarget "visceral peritoneum of jejunum" . [] oboInOwl:hasDbXref "BIRNLEX:2548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003338 ; owl:annotatedTarget "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003338 ; owl:annotatedTarget "we follow MA in including separate classes for ganglion and peripheral nervous system, even though for vertebrates gangia are always in the PNS" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003338 ; owl:annotatedTarget "peripheral nervous system ganglion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003339 ; owl:annotatedTarget "A ganglion that is part of a central nervous system [Automatically generated definition]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003339 ; owl:annotatedTarget "this has no subclasses in FMA. In EHDAA2 and EMAPA it has only the cranial ganglia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003339 ; owl:annotatedTarget "central nervous system ganglion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003339 ; owl:annotatedTarget "ganglion of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003339 ; owl:annotatedTarget "neuraxis ganglion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "A mucosa that is part of an anal canal [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Anal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "UMLS:C0227414" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal viewed anatomically mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal viewed anatomically mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal viewed anatomically mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal canal viewed anatomically organ mucosa" . [] oboInOwl:hasDbXref "FMA:74654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal mucosa" . [] oboInOwl:hasDbXref "FMA:74654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal region mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal region mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal region mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anal region organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anatomical anal canal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anatomical anal canal mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anatomical anal canal mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "anatomical anal canal organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of anal canal viewed anatomically" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of anatomical anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of organ of anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of organ of anal canal viewed anatomically" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of organ of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucosa of organ of anatomical anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucous membrane of anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucous membrane of anal canal viewed anatomically" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucous membrane of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "mucous membrane of anatomical anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "organ mucosa of anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "organ mucosa of anal canal viewed anatomically" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "organ mucosa of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003342 ; owl:annotatedTarget "organ mucosa of anatomical anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "A mucosa that is part of a oral opening [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of oral opening" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of oral part of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of organ of oral opening" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of organ of oral part of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of organ of oral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of organ of subdivision of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucosa of subdivision of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucous membrane of oral opening" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucous membrane of oral part of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucous membrane of oral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "mucous membrane of subdivision of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral opening mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral opening mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral opening mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral opening organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral part of face mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral part of face mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral part of face mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral part of face organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral region mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral region mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral region mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "oral region organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "organ mucosa of oral opening" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "organ mucosa of oral part of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "organ mucosa of oral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "organ mucosa of subdivision of mouth" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "CAS:488-81-3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "subdivision of mouth mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "subdivision of mouth mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "subdivision of mouth mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003343 ; owl:annotatedTarget "subdivision of mouth organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "A mucosa that is part of a rectum [Automatically generated definition]." . _:genid126809 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "mucosa of organ of rectum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005971 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "mucous membrane of rectum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "organ mucosa of rectum" . [] oboInOwl:hasDbXref "FMA:15033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectal mucosa" . [] oboInOwl:hasDbXref "FMA:15033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectal mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003346 ; owl:annotatedTarget "rectum organ mucosa" . [] oboInOwl:hasDbXref "BTO:0003752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003350 ; owl:annotatedTarget "A layer of epithelial cells on the surface of the mucosa." . [] oboInOwl:hasDbXref "BTO:0003752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003350 ; owl:annotatedTarget "lamina epithelialis mucosa" . _:genid126824 oboInOwl:hasDbXref "BTO:0003752" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003350 ; owl:annotatedTarget "lamina epithelialis mucosae" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008947 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget _:genid127883 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget _:genid127885 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "An epithelium that is part of a pharynx [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001174" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "epithelial tissue of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "epithelium of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "pharynx epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003351 ; owl:annotatedTarget "pharynx epithelium" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003352 ; owl:annotatedTarget _:genid127897 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003352 ; owl:annotatedTarget "An epithelium that is part of a midgut." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003352 ; owl:annotatedTarget "epithelial tissue of midgut" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003352 ; owl:annotatedTarget "midgut epithelial tissue" . [] oboInOwl:hasDbXref "BTO:0005053", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003352 ; owl:annotatedTarget "midgut epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003353 ; owl:annotatedTarget "An epithelium that is part of a hindgut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003353 ; owl:annotatedTarget "epithelial tissue of hindgut" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003353 ; owl:annotatedTarget "hindgut epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003353 ; owl:annotatedTarget "hindgut epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003354 ; owl:annotatedTarget "An epithelium that is part of a rectum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003354 ; owl:annotatedTarget "epithelial tissue of rectum" . [] oboInOwl:hasDbXref "FMA:17510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003354 ; owl:annotatedTarget "rectal epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003354 ; owl:annotatedTarget "rectum epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003354 ; owl:annotatedTarget "rectum epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "An epithelium that is part of a incisor tooth [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "epithelial tissue of incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "epithelial tissue of incisor tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "epithelium of incisor tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "incisor epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "incisor epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "incisor tooth epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003355 ; owl:annotatedTarget "incisor tooth epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003356 ; owl:annotatedTarget "An epithelium that is part of a nasal septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003356 ; owl:annotatedTarget "epithelial tissue of nasal septum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003356 ; owl:annotatedTarget "nasal septum epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003356 ; owl:annotatedTarget "nasal septum epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "An epithelium that is part of a tongue [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Tongue_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "UMLS:C1710436" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "epithelial tissue of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "tongue epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "tongue epithelium" . [] oboInOwl:hasDbXref "BTO:0000992" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003357 ; owl:annotatedTarget "lingual epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003358 ; owl:annotatedTarget "An epithelium that is part of a soft palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003358 ; owl:annotatedTarget "epithelial tissue of soft palate" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "Gmelin:82894" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003358 ; owl:annotatedTarget "soft palate epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003358 ; owl:annotatedTarget "soft palate epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "An epithelium that is part of a submandibular gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "epithelial tissue of submandibular gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "submandibular gland epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "submandibular gland epithelium" . [] oboInOwl:hasDbXref "BTO:0004557" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "submandibular duct epithelium" . [] oboInOwl:hasDbXref "BTO:0004557" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "submandibular gland duct epithelium" . [] oboInOwl:hasDbXref "EMAPA:18813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003359 ; owl:annotatedTarget "submaxillary gland epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "An epithelium that is part of a parotid gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "epithelial tissue of parotid gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "epithelium of parotid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "epithelium of parotid gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "parotid epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "parotid epithelium" . _:genid126923 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "parotid gland epithelial tissue" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001716 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "parotid gland epithelium" . [] oboInOwl:hasDbXref "BTO:0004555" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003360 ; owl:annotatedTarget "parotid gland duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "An epithelium that is part of a sublingual gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "Rivinus'gland epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "Rivinus'gland epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "ductus sublingualis epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "ductus sublingualis epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "epithelial tissue of Rivinus'gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "epithelial tissue of ductus sublingualis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "epithelial tissue of sublingual gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "epithelium of Rivinus'gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "epithelium of ductus sublingualis" . _:genid126940 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "sublingual gland epithelial tissue" ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0000084 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "sublingual gland epithelium" . [] oboInOwl:hasDbXref "BTO:0004559" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "sublingual duct epithelium" . [] oboInOwl:hasDbXref "BTO:0004559" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003361 ; owl:annotatedTarget "sublingual gland duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003364 ; owl:annotatedTarget "An epithelium that is part of a right lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003364 ; owl:annotatedTarget "epithelial tissue of right lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003364 ; owl:annotatedTarget "right lung epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003364 ; owl:annotatedTarget "right lung epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003365 ; owl:annotatedTarget "An epithelium that is part of a left lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003365 ; owl:annotatedTarget "epithelial tissue of left lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003365 ; owl:annotatedTarget "left lung epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003365 ; owl:annotatedTarget "left lung epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003368 ; owl:annotatedTarget "An epithelium that is part of a hard palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003368 ; owl:annotatedTarget "epithelial tissue of hard palate" . _:genid126966 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003368 ; owl:annotatedTarget "hard palate epithelial tissue" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003368 ; owl:annotatedTarget "hard palate epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget _:genid128029 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget _:genid128032 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "An unilaminar epithelium that surrounds a pelvic appendage bud." . [] oboInOwl:hasDbXref "VHOG:0001048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "hindlimb ectoderm" . [] oboInOwl:hasDbXref "EMAPA:16780" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "hindlimb bud ectoderm" . [] oboInOwl:hasDbXref "VHOG:0001048" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "hindlimb ectoderm" . [] oboInOwl:hasDbXref "EHDAA2:0001034" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "lower limb bud ectoderm" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "pelvic fin bud ectoderm" . _:genid126981 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003371 ; owl:annotatedTarget "leg ectoderm" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget _:genid128045 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget _:genid128048 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "An unilaminar epithelium that surrounds a pectoral appendage bud." . [] oboInOwl:hasDbXref "EMAPA:16407" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "forelimb bud ectoderm" . [] oboInOwl:hasDbXref "VHOG:0001047" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "forelimb ectoderm" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "pectoral fin bud ectoderm" . [] oboInOwl:hasDbXref "EHDAA2:0002134" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "upper limb bud ectoderm" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "wing ectoderm" . _:genid126995 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003372 ; owl:annotatedTarget "arm ectoderm" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003371 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:15234337" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003373 ; owl:annotatedTarget "An ectoderm that is part of a footplate." . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003374 ; owl:annotatedTarget _:genid128068 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003374 ; owl:annotatedTarget "An extraembryonic structure that develops_from a ectoderm and is part of a chorion." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003374 ; owl:annotatedTarget "chorion ectoderm" . [] oboInOwl:hasDbXref "BTO:0005145" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003374 ; owl:annotatedTarget "chorionic epithelium" . _:genid127013 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002078, obo:UBERON_0003371 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "cardiac muscle of cardiac right atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "cardiac muscle of heart right atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "cardiac muscle tissue of heart right atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "cardiac muscle tissue of right atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "cardiac muscle tissue of right atrium of heart" . [] oboInOwl:hasDbXref "EHDAA2:0004155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "right atrium heart muscle" . [] oboInOwl:hasDbXref "VHOG:0001227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "right atrium myocardium" . _:genid127023 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "textus muscularis of myocardium of right atrium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "textus muscularis of myocardium of right atrium of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003379 ; owl:annotatedTarget "textus muscularis of myocardium of right cardiac atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "cardiac left atrium cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "cardiac left atrium cardiac muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "cardiac muscle of cardiac left atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "cardiac muscle of heart left atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "cardiac muscle of left atrium of heart" . [] oboInOwl:hasDbXref "EHDAA2:0004154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "left atrium heart muscle" . [] oboInOwl:hasDbXref "VHOG:0001225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "left atrium myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "textus muscularis of myocardium of cardiac left atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "textus muscularis of myocardium of heart left atrium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000613 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "textus muscularis of myocardium of left atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "textus muscularis of myocardium of left atrium of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003380 ; owl:annotatedTarget "textus muscularis of myocardium of left cardiac atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003381 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:83452" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003381 ; owl:annotatedTarget "cardiac muscle tissue of right ventricle" . [] oboInOwl:hasDbXref "GO:0003221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003381 ; owl:annotatedTarget "right ventricular cardiac muscle tissue" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMCID:PMC1312421", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000613 ; owl:annotatedTarget "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." . [] oboInOwl:hasDbXref "VHOG:0001236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003381 ; owl:annotatedTarget "right ventricle cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003382 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:83453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003382 ; owl:annotatedTarget "cardiac muscle tissue of left ventricle" . [] oboInOwl:hasDbXref "GO:0003220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003382 ; owl:annotatedTarget "left ventricular cardiac muscle tissue" . [] oboInOwl:hasDbXref "VHOG:0001234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003382 ; owl:annotatedTarget "left ventricle cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:84084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "cardiac muscle tissue of interventricular septum" . [] oboInOwl:hasDbXref "VHOG:0000999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "interventricular septum cardiac muscle" . [] oboInOwl:hasDbXref "EHDAA2:0004158" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "interventricular septum heart muscle" . [] oboInOwl:hasDbXref "VHOG:0000999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "interventricular septum myocardium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003383 ; owl:annotatedTarget "interventricular septum muscle" . _:genid127073 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003384 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011272 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003384 ; owl:annotatedTarget "pharynx skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003384 ; owl:annotatedTarget "pharynx skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003384 ; owl:annotatedTarget "skeletal muscle tissue of pharynx" . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0005247" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003386 ; owl:annotatedTarget "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." . [] oboInOwl:hasDbXref "MA:0001268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003386 ; owl:annotatedTarget "ocular smooth muscle" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003387 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Trachea_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003387 ; owl:annotatedTarget "UMLS:C1710458" . [] oboInOwl:hasDbXref "MA:0001863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003387 ; owl:annotatedTarget "trachea smooth muscle" . [] oboInOwl:hasDbXref "BTO:0001391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003387 ; owl:annotatedTarget "tracheal smooth muscle" . _:genid127095 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002407, obo:UBERON_0003372 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "A mesothelium that is part of a pericardium [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "cavity of pericardial sac meso-epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "cavity of pericardial sac mesothelium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:16664320" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000617 ; owl:annotatedTarget "A neuron that uses GABA as a vesicular neurotransmitter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "meso-epithelium of cavity of pericardial sac" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "meso-epithelium of pericardial cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "mesothelium of cavity of pericardial sac" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "pericardial cavity meso-epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003388 ; owl:annotatedTarget "pericardial cavity mesothelium" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "A mesothelium that is part of a diaphragm [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "diaphragm meso-epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "diaphragm mesothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "meso-epithelium of diaphragm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "meso-epithelium of thoracic diaphragm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "mesothelium of thoracic diaphragm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "thoracic diaphragm meso-epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003389 ; owl:annotatedTarget "thoracic diaphragm mesothelium" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000622 ; owl:annotatedTarget "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "A mesothelium that is part of a pleural cavity [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "meso-epithelium of pleural cavity" . _:genid127123 oboInOwl:hasDbXref "FMA:18148" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "mesothelium of pleura" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010388 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "pleural cavity meso-epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "pleural cavity mesothelium" . [] oboInOwl:hasDbXref "EMAPA:16775" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "pleural mesothelium" . [] oboInOwl:hasDbXref "EMAPA:16775" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003390 ; owl:annotatedTarget "pleura" . _:genid127132 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "A mesentery that is part of a urinary system [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000305 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "excretory system mesentery" . _:genid127134 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "mesentery of excretory system" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002532 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "mesentery of renal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "mesentery of systema urinaria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "renal system mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "systema urinaria mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003393 ; owl:annotatedTarget "urinary system mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003394 ; owl:annotatedTarget "A mesentery that is part of a hindgut [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003394 ; owl:annotatedTarget "hindgut mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003395 ; owl:annotatedTarget "A mesentery that is part of a rectum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003395 ; owl:annotatedTarget "rectum mesentery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget obo:UBERON_0007826 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "A mesentery that is part of a colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "colon mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "large bowel mesentery" . [] oboInOwl:hasDbXref "FMA:14645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "large intestinal mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "mesentery of large bowel" . [] oboInOwl:hasDbXref "FMA:14645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "mesentery of large intestine" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003396 ; owl:annotatedTarget "mesocolon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003397 ; owl:annotatedTarget "A mesentery that is part of a duodenum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003397 ; owl:annotatedTarget "duodenum mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003398 ; owl:annotatedTarget "A mesentery that is part of a jejunum [Automatically generated definition]." . _:genid127175 oboInOwl:hasDbXref "http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003398 ; owl:annotatedTarget "mesojejunum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "A zone of skin that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:38265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "forearm skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "lower arm skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "lower segment of arm skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "skin of antebrachial region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "skin of lower arm" . _:genid127186 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "skin of lower segment of arm" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005728 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003403 ; owl:annotatedTarget "skin of zeugopod of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003406 ; owl:annotatedTarget "A cartilage element that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003406 ; owl:annotatedTarget "apparatus respiratorius cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003406 ; owl:annotatedTarget "cartilage of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003406 ; owl:annotatedTarget "respiratory system cartilage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003407 ; owl:annotatedTarget "A cartilage that is part of a nasal septum [Automatically generated definition]." . _:genid127201 oboInOwl:hasDbXref "FMA:59503" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003407 ; owl:annotatedTarget "cartilago septal nasi" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004871 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003407 ; owl:annotatedTarget "nasal septum cartilage" . _:genid127203 oboInOwl:hasDbXref "FMA:59503" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003407 ; owl:annotatedTarget "septal nasal cartilage" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005728 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "A gland that is part of a digestive tract [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "digestive tract gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "gland of digestive tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "gland of lower gastrointestinal tract" . [] oboInOwl:hasDbXref "MA:0003202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "gut gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003408 ; owl:annotatedTarget "lower gastrointestinal tract gland" . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/lingual%20gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003409 ; owl:annotatedTarget "Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003409 ; owl:annotatedTarget "lingual gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003409 ; owl:annotatedTarget "tongue gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "Mesenchyme that is part of a pelvic appendage bud." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001386" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "Mesoderm part of pelvic fin bud.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "leg mesenchyme" . [] oboInOwl:hasDbXref "EHDAA2:0001035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "lower limb bud mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:16781" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "hindlimb bud mesenchyme" . [] oboInOwl:hasDbXref "ZFA:0001386" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "mesoderm pelvic fin bud" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003412 ; owl:annotatedTarget "pelvic fin bud mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "Mesenchyme that is part of a pectoral appendage bud." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000789" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "Mesoderm that is part of the pectoral fin bud.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "arm mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:16408" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "forelimb bud mesenchyme" . [] oboInOwl:hasDbXref "ZFA:0000789" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "mesoderm pectoral fin bud" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "pectoral fin bud mesenchyme" . [] oboInOwl:hasDbXref "EHDAA2:0002135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "upper limb bud mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003413 ; owl:annotatedTarget "wing mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "Mesenchyme that is part of a developing mandible [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "bone of lower jaw mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "bone of ventral mandibular arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "bone organ of lower jaw mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "bone organ of ventral mandibular arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "lower jaw bone mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "lower jaw bone organ mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mandible mesenchyme" . _:genid127258 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mandibulla mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of bone of lower jaw" . _:genid127260 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of bone of ventral mandibular arch" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of bone organ of lower jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of bone organ of ventral mandibular arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of lower jaw bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of lower jaw bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of mandibulla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of ventral mandibular arch bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "mesenchyme of ventral mandibular arch bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "ventral mandibular arch bone mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003414 ; owl:annotatedTarget "ventral mandibular arch bone organ mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003415 ; owl:annotatedTarget "Mesenchyme that is part of a developing nasal septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003415 ; owl:annotatedTarget "nasal septum mesenchyme" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:15771571" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000623 ; owl:annotatedTarget "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003416 ; owl:annotatedTarget "Mesenchyme that is part of a developing tongue [Automatically generated definition]." . [] oboInOwl:hasDbXref "EHDAA2:0004614" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003416 ; owl:annotatedTarget "tongue mesenchyme" . _:genid127284 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945, obo:UBERON_0001733 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003417 ; owl:annotatedTarget "Mesenchyme that is part of a developing soft palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003417 ; owl:annotatedTarget "soft palate mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003418 ; owl:annotatedTarget "Mesenchyme that is part of a developing submandibular gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003418 ; owl:annotatedTarget "submandibular gland mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:18814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003418 ; owl:annotatedTarget "submaxillary gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003419 ; owl:annotatedTarget "Mesenchyme that is part of a developing parotid gland [Automatically generated definition]." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003419 ; owl:annotatedTarget "mesenchyme of parotid gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003419 ; owl:annotatedTarget "parotid gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003419 ; owl:annotatedTarget "parotid mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "Mesenchyme that is part of a developing sublingual gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "Rivinus'gland mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "ductus sublingualis mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "mesenchyme of Rivinus'gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "mesenchyme of ductus sublingualis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003420 ; owl:annotatedTarget "sublingual gland mesenchyme" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003422 ; owl:annotatedTarget _:genid128379 . [] oboInOwl:hasDbXref "Wikipedia:Wharton's_jelly" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003422 ; owl:annotatedTarget "A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP]." . [] oboInOwl:hasDbXref "EMAPA:26127" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003422 ; owl:annotatedTarget "Wharton's jelly" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003422 ; owl:annotatedTarget "umbilical cord mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003424 ; owl:annotatedTarget "Mesenchyme that is part of a developing hard palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003424 ; owl:annotatedTarget "hard palate mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003425 ; owl:annotatedTarget "A lymph node that is located in a kidney [Automatically generated definition]." . [] oboInOwl:source "PMID:16624319" ; oboInOwl:taxon "NCBITaxon:10090" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003425 ; owl:annotatedTarget "Dorsal to the ipsilateral kidney nearby the renal blood vessels, caudal to the adrenal gland" . [] oboInOwl:source "ncithesaurus:Renal_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003425 ; owl:annotatedTarget "UMLS:C2699031" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003425 ; owl:annotatedTarget "kidney lymph node" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003425 ; owl:annotatedTarget "lymph node of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "An adipose tissue that is part of a dermis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "adipose tissue of dermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "dermis fat tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "dermis fatty tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "fat tissue of dermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003426 ; owl:annotatedTarget "fatty tissue of dermis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000624 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "MP:0000010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003427 ; owl:annotatedTarget "The encapsulated adipose tissue in the abdomen." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003427 ; owl:annotatedTarget "abdomen fat pad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003427 ; owl:annotatedTarget "fat pad of abdomen" . [] oboInOwl:hasDbXref "MP:0005335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "The encapsulated adipose tissue associated with the ovaries or testes." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000157" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "Anatomical structure associated with the gonads which vary in form among amphibians but are primarily composed of adipose tissue and are thought to be a source of nutrients for the gonads.[AAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "fat pad of gonad" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000624 ; owl:annotatedTarget "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "fat pad of gonads" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "gonad fat pad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003428 ; owl:annotatedTarget "gonadal fat pad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003429 ; owl:annotatedTarget "A nerve that is part of an abdomen [Automatically generated definition]." . _:genid127368 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003429 ; owl:annotatedTarget "nerve of abdomen" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010091 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003430 ; owl:annotatedTarget "A nerve that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003430 ; owl:annotatedTarget "EMAPA:37263" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003430 ; owl:annotatedTarget "neck (volume) nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003430 ; owl:annotatedTarget "nerve of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003430 ; owl:annotatedTarget "nerve of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003431 ; owl:annotatedTarget "A nerve that is part of a leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003431 ; owl:annotatedTarget "EMAPA:37343" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003431 ; owl:annotatedTarget "nerve of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "A nerve that is part of a chest [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "EMAPA:37266" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "anterior thoracic region nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "anterolateral part of thorax nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "front of thorax nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "nerve of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "nerve of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "nerve of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003432 ; owl:annotatedTarget "nerve of front of thorax" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:17979222" . _:genid127400 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042, obo:UBERON_0001460 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003433 ; owl:annotatedTarget "A nerve that is part of an arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003433 ; owl:annotatedTarget "EMAPA:37336" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003433 ; owl:annotatedTarget "brachial region nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003433 ; owl:annotatedTarget "nerve of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003433 ; owl:annotatedTarget "nerve of brachial region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003434 ; owl:annotatedTarget "A nerve that is part of a wrist [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003434 ; owl:annotatedTarget "EMAPA:37339" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003434 ; owl:annotatedTarget "carpal region nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003434 ; owl:annotatedTarget "nerve of carpal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003434 ; owl:annotatedTarget "nerve of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "A nerve that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "EMAPA:37348" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "digit of foot nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "digit of terminal segment of free lower limb nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "digitus pedis nerve" . [] oboInOwl:hasDbXref "MA:0000649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "foot digit nerve" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "hind limb digit nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of digit of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of digitus pedis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000625 ; owl:annotatedTarget obo:CL_0000791 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of foot digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of terminal segment of free lower limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "nerve of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "terminal segment of free lower limb digit nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "toe nerve" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003435 ; owl:annotatedTarget "foot digit nerve" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000625 ; owl:annotatedTarget "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003436 ; owl:annotatedTarget "A nerve that is part of a shoulder [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003436 ; owl:annotatedTarget "EMAPA:37335" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003436 ; owl:annotatedTarget "nerve of shoulder" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "A nerve that innervates an eyelid." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "EMAPA:37535" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "blepharon nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "nerve of blepharon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "nerve of eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003437 ; owl:annotatedTarget "palpebral nerve" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003438 ; owl:annotatedTarget "Any nerve that innervates the iris." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003438 ; owl:annotatedTarget "nerve of iris" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "EMAPA:37264" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "nerve of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "nerve of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "torso nerve" . [] oboInOwl:hasDbXref "MA:0000515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003439 ; owl:annotatedTarget "trunk nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003440 ; owl:annotatedTarget "A nerve that is part of a limb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003440 ; owl:annotatedTarget "EMAPA:37291" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003440 ; owl:annotatedTarget "nerve of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "A nerve that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "EMAPA:37334" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "fore limb nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "nerve of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "nerve of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "nerve of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "nerve of upper extremity" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003441 ; owl:annotatedTarget "wing nerve" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000626 ; owl:annotatedTarget "Granule cell that is part of the olfactory bulb." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "A nerve that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "EMAPA:37342" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "hind limb nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "nerve of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "nerve of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "nerve of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003442 ; owl:annotatedTarget "nerve of lower extremity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:23564164" . [] oboInOwl:hasDbXref "FB:ma", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000630 ; owl:annotatedTarget "A cell whose primary function is to support other cell types." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "A nerve that is located in a thoracic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "EMAPA:37267" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "cavity of chest nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "cavity of thorax nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "chest cavity nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "nerve of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "nerve of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "nerve of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "nerve of pectoral cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "nerve of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003443 ; owl:annotatedTarget "pectoral cavity nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003444 ; owl:annotatedTarget "A nerve that is part of a pelvis [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003444 ; owl:annotatedTarget "EMAPA:37269" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003444 ; owl:annotatedTarget "nerve of pelvis" . _:genid127523 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387, obo:UBERON_0007798 . _:genid127525 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003445 ; owl:annotatedTarget "A nerve that is part of a foot [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003445 ; owl:annotatedTarget "EMAPA:37347" . [] oboInOwl:hasDbXref "MA:0000653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003445 ; owl:annotatedTarget "foot nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003445 ; owl:annotatedTarget "nerve of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "A nerve that is part of an ankle [Automatically generated definition]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "FMA placement dubious" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "EMAPA:37346" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "nerve of ankle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "tarsal region nerve" . [] oboInOwl:hasDbXref "FMA:86901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003446 ; owl:annotatedTarget "neural network of ankle" . _:genid127541 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002389, obo:UBERON_0009920 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "A nerve that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "EMAPA:37341" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "digit of hand nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "digit of terminal segment of free upper limb nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "digitus manus nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "finger nerve" . [] oboInOwl:hasDbXref "MA:0000625" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "hand digit nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of digit of terminal segment of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of digitus manus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of hand digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "nerve of terminal segment of free upper limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003447 ; owl:annotatedTarget "terminal segment of free upper limb digit nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003448 ; owl:annotatedTarget "A nerve that is part of a manus [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003448 ; owl:annotatedTarget "EMAPA:37340" . [] oboInOwl:hasDbXref "MA:0000629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003448 ; owl:annotatedTarget "hand nerve" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003448 ; owl:annotatedTarget "nerve of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003448 ; owl:annotatedTarget "nerve of manus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget obo:CL_0002320 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "An intervertebral disk that is part of a tail [Automatically generated definition]." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "intervertebral disc of post-ventral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "intervertebral disc of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "intervertebral disk of post-ventral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "intervertebral disk of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "tail intervertebral disk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003449 ; owl:annotatedTarget "tail spinal disc" . [] oboInOwl:hasDbXref "GOC:dsd", "MESH:D055166", "PMID:12808230", "PMID:17239632", "PMID:18222966", "PMID:9302568", "http://en.wikipedia.org/wiki/Hepatic_stellate_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "An incisor tooth that is part of a upper jaw [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Upper_Jaw_Incisor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "UMLS:C1710579" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "incisor of palatoquadrate arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "incisor of upper jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "incisor tooth of palatoquadrate arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "incisor tooth of upper jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "palatoquadrate arch incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "palatoquadrate arch incisor tooth" . [] oboInOwl:hasDbXref "PMID:12808230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000632 ; owl:annotatedTarget "vitamin A-storing cells" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "upper incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "upper jaw incisor tooth" . [] oboInOwl:hasDbXref "FMA:55712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "maxillary incisor tooth" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003450 ; owl:annotatedTarget "premaxillary tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "An incisor tooth that is part of a lower jaw [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Lower_Jaw_Incisor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "UMLS:C1708755" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "incisor of lower jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "incisor of ventral mandibular arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "incisor tooth of lower jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "incisor tooth of ventral mandibular arch" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "lower incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "lower jaw incisor tooth" . [] oboInOwl:hasDbXref "BTO:0001942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "mandibular incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "ventral mandibular arch incisor" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003451 ; owl:annotatedTarget "ventral mandibular arch incisor tooth" . [] oboInOwl:hasDbXref "GOC:NV", "PMID:21911394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000636 ; owl:annotatedTarget "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "EMAPA:37580" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "apparatus respiratorius lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "apparatus respiratorius lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "lymph vessel of apparatus respiratorius" . _:genid127618 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "lymph vessel of respiratory system" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009526 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "lymphatic vessel of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "lymphatic vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003456 ; owl:annotatedTarget "respiratory system lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "A bone that is part of a head [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "adult head bone" . _:genid127628 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "adult head bone organ" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006905 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "bone of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "bone of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "bone organ of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "bone organ of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "head bone organ" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003457 ; owl:annotatedTarget "craniofacial bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "A bone that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "EMAPA:37246" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "bone of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "bone of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "bone organ of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "bone organ of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "neck (volume) bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "neck (volume) bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003458 ; owl:annotatedTarget "neck bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "A bone that is part of a chest [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "anterior thoracic region bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "anterior thoracic region bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "anterolateral part of thorax bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "anterolateral part of thorax bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone organ of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone organ of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone organ of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "bone organ of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "chest bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "front of thorax bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003459 ; owl:annotatedTarget "front of thorax bone organ" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000637 ; owl:annotatedTarget "A cell that stains readily in the anterior pituitary gland." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia." . _:genid127674 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "EMAPA:37303" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003412 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "arm bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "bone of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "bone organ of arm" . [] oboInOwl:hasDbXref "GAID:178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003460 ; owl:annotatedTarget "bone of upper extremity" . [] oboInOwl:notes "UBERONREF:0000003" ; oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003461 ; owl:annotatedTarget obo:UBERON_0010741 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003461 ; owl:annotatedTarget "A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003461 ; owl:annotatedTarget "this is a forelimb bone in MA, but this would lead to part-disjointness violations." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003461 ; owl:annotatedTarget "bone of shoulder" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000638 ; owl:annotatedTarget "An acidophilic chromophil cell that of the anterior pituitary gland." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget _:genid128756 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "A bone that is part of a facial skeleton [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Facial_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "UMLS:C0015455" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "bone of facial skeleton" . [] oboInOwl:hasDbXref "EMAPA:19019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "facial bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "facial skeleton bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "bone of viscerocranium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref "JB:jb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000642 ; owl:annotatedTarget "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003462 ; owl:annotatedTarget "viscerocranium bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "A bone that is part of a trunk [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "bone of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "bone of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "bone organ of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "bone organ of trunk" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000646 ; owl:annotatedTarget "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "torso bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "torso bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003463 ; owl:annotatedTarget "trunk bone organ" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle)." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "the MA class is actually bone of pelvic complex; in contrast the NCIT class excludes ilium etc" . [] oboInOwl:source "ncithesaurus:Bone_of_the_Lower_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "UMLS:C0448188" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone organ of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone organ of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "bone organ of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "hind limb bone" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "ISBN:0815332181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000649 ; owl:annotatedTarget "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "hind limb bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003464 ; owl:annotatedTarget "hindlimb bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "A bone that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "antebrachial region bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "antebrachial region bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "arm zeugopod bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "arm zeugopod bone organ" . [] oboInOwl:hasDbXref "MA:0000598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "lower arm bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "zeugopod bone, forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "zeugopod bone, upper" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003466 ; owl:annotatedTarget "wing zeugopod bone" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000650 ; owl:annotatedTarget "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003468 ; owl:annotatedTarget _:genid128814 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003468 ; owl:annotatedTarget _:genid128816 . [] oboInOwl:hasDbXref "Wikipedia:Ureteral_branches_of_renal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003468 ; owl:annotatedTarget "The ureteral branches of renal artery are small branches which supply the ureter." . [] oboInOwl:hasDbXref "MA:0002074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003468 ; owl:annotatedTarget "ureteric artery" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003468 ; owl:annotatedTarget "EMAPA:37676" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003469 ; owl:annotatedTarget "An artery that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003469 ; owl:annotatedTarget "EMAPA:37569" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget _:genid128832 . [] oboInOwl:hasDbXref "Wikipedia:Superior_labial_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "EMAPA:37430" . [] oboInOwl:hasDbXref "Wikipedia:Superior_labial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "arteria labialis superior" . [] oboInOwl:hasDbXref "Wikipedia:Superior_labial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "ramus labialis superior arteriae facialis" . [] oboInOwl:hasDbXref "FMA:49570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "superior labial artery" . [] oboInOwl:hasDbXref "FMA:49570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003470 ; owl:annotatedTarget "superior labial branch of facial artery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget _:genid128845 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_labial_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:16687276", "http://en.wikipedia.org/wiki/Pinealocyte" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000652 ; owl:annotatedTarget "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "EMAPA:37429" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_labial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "arteria labialis inferior" . [] oboInOwl:hasDbXref "FMA:49567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "inferior labial artery" . [] oboInOwl:hasDbXref "FMA:49567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "inferior labial branch of facial artery" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "ramus labialis inferior (arteria facialis)" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_labial_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003471 ; owl:annotatedTarget "ramus labialis inferior arteriae facialis" . [] oboInOwl:hasDbXref "Wikipedia:Cerebellar_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003472 ; owl:annotatedTarget "An artery that supplies blood to the cerebellum." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003472 ; owl:annotatedTarget "EMAPA:37074" . [] oboInOwl:source "ncithesaurus:Cerebellar_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003472 ; owl:annotatedTarget "UMLS:C0226246" . [] oboInOwl:hasDbXref "https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003473 ; owl:annotatedTarget "An artery that is part of a thoracic cavity[cjm]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003473 ; owl:annotatedTarget "in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "Reaxys:1720524" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003473 ; owl:annotatedTarget "EMAPA:37241" . [] oboInOwl:hasDbXref "MESH:A07.231.114.891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003473 ; owl:annotatedTarget "thoracic artery" . [] oboInOwl:hasDbXref "Wikipedia:Meningeal_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003474 ; owl:annotatedTarget "One of the arteries supplying a meninix[Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003474 ; owl:annotatedTarget "EMAPA:37104" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003475 ; owl:annotatedTarget "A vein that is part of a ureter [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003475 ; owl:annotatedTarget "EMAPA:37679" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003475 ; owl:annotatedTarget "ureter vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003475 ; owl:annotatedTarget "vein of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "A vein that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "EMAPA:37584" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "apparatus respiratorius vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "respiratory system vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "vein of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003476 ; owl:annotatedTarget "vein of respiratory system" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget _:genid128898 . [] oboInOwl:hasDbXref "Wikipedia:Superior_labial_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget "The inferior labial vein is the vein receiving blood from the upper lip." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget "EMAPA:37204" . [] oboInOwl:hasDbXref "FMA:52538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget "superior labial vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget "upper lip vein" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003477 ; owl:annotatedTarget "vena labialis superior" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000654 ; owl:annotatedTarget obo:CL_0000023 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget _:genid128909 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_labial_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "The inferior labial vein is the vein receiving blood from the lower lip." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "EMAPA:37202" . [] oboInOwl:hasDbXref "FMA:52541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "inferior labial vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "lower lip vein" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "vena labialis inferior" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_labial_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003478 ; owl:annotatedTarget "venae labiales inferiores" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000654 ; owl:annotatedTarget "A primary oocyte is an oocyte that has not completed female meosis I." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "A vein that is part of a thoracic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "EMAPA:37242" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "cavity of chest vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "cavity of thorax vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "chest cavity vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "pectoral cavity vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "vein of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "vein of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "vein of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "vein of pectoral cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003479 ; owl:annotatedTarget "vein of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003480 ; owl:annotatedTarget "A vein that is part of a clitoris [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003480 ; owl:annotatedTarget "EMAPA:37201" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003480 ; owl:annotatedTarget "clitoris vein" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Tail_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "A vein that is part of a tail [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "EMAPA:37761" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "post-vent region vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "vein of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "vein of tail" . [] oboInOwl:hasDbXref "Wikipedia:Tail_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003481 ; owl:annotatedTarget "caudal vein" . _:genid127883 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "A portion of vein that is part of a trabecular bone tissue [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "EMAPA:37203" . _:genid127885 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "spongy bone vein" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "trabecular bone tissue vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "trabecular bone vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "vein of spongy bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003482 ; owl:annotatedTarget "vein of trabecular bone tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "EMAPA:37766" . _:genid127897 oboInOwl:source "ncithesaurus:Thymic_Lymphoid_Tissue" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "UMLS:C1515429" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001045 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "lymphoid tissue of thymus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "lymphoid tissue of thymus gland" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "(2R,3s,4S)-pentane-1,2,3,4,5-pentol" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003483 ; owl:annotatedTarget "thymus gland lymphoid tissue" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget obo:UBERON_0003487 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "EMAPA:37531" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "camera-type eye sebaceous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "sebaceous gland of camera-type eye" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000655 ; owl:annotatedTarget obo:CL_0000023 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "sebaceous gland of vertebrate eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003484 ; owl:annotatedTarget "vertebrate eye sebaceous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003485 ; owl:annotatedTarget "A sebaceous gland that is part of a vagina [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003485 ; owl:annotatedTarget "EMAPA:37793" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003485 ; owl:annotatedTarget "sebaceous gland of vagina" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000655 ; owl:annotatedTarget "A secondary oocyte is an oocyte that has not completed meiosis II." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003487 ; owl:annotatedTarget _:genid128990 . [] oboInOwl:hasDbXref "MP:0009535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003487 ; owl:annotatedTarget "A holocrine gland of the dermis that secretes sebum into hair follicles." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003487 ; owl:annotatedTarget "sebaceous gland of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "A lactiferous gland that is part of the abdominal region [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "abdomen lactiferous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "abdomen lobe of breast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "abdomen lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "abdomen mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "lactiferous gland of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "lobe of breast of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "lobe of mammary gland of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003488 ; owl:annotatedTarget "mammary gland of abdomen" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget _:genid129011 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget _:genid129013 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "EMAPA:37575" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius blood capillary endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius capillary endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius capillary vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius endothelium of blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius endothelium of capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "apparatus respiratorius endothelium of capillary vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "blood capillary endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "blood capillary endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "capillary endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "capillary endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "capillary vessel endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "capillary vessel endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of blood capillary of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of blood capillary of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of capillary of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of capillary of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of capillary vessel of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "endothelium of capillary vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "respiratory system blood capillary endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "respiratory system capillary vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "respiratory system endothelium of blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "respiratory system endothelium of capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003489 ; owl:annotatedTarget "respiratory system endothelium of capillary vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003494 ; owl:annotatedTarget "A venule that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003494 ; owl:annotatedTarget "EMAPA:37587" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003494 ; owl:annotatedTarget "apparatus respiratorius venule" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003494 ; owl:annotatedTarget "venule of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003494 ; owl:annotatedTarget "venule of respiratory system" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003495 ; owl:annotatedTarget _:genid129053 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003495 ; owl:annotatedTarget "An arteriole that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003495 ; owl:annotatedTarget "EMAPA:37568" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003496 ; owl:annotatedTarget _:genid129061 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003496 ; owl:annotatedTarget "A blood vessel that is part of a head [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003496 ; owl:annotatedTarget "adult head blood vessel" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000656 ; owl:annotatedTarget obo:CL_0000017 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003496 ; owl:annotatedTarget "blood vessel of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003496 ; owl:annotatedTarget "blood vessel of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003497 ; owl:annotatedTarget "A blood vessel that is part of an abdomen [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003497 ; owl:annotatedTarget "blood vessel of abdomen" . [] oboInOwl:notes "abdominal aorta artery" ; a owl:Axiom ; owl:annotatedProperty rdfs:seeAlso ; owl:annotatedSource obo:UBERON_0003497 ; owl:annotatedTarget "UBERON:0012254" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "Ribitol" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000656 ; owl:annotatedTarget "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003498 ; owl:annotatedTarget "A blood vessel that is part of a heart [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003498 ; owl:annotatedTarget "blood vessel of heart" . [] oboInOwl:hasDbXref "EMAPA:35397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003498 ; owl:annotatedTarget "cardiac blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003499 ; owl:annotatedTarget "A blood vessel that is part of a brain [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003499 ; owl:annotatedTarget "blood vessel of brain" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003500 ; owl:annotatedTarget "A blood vessel that is part of a cornea [Automatically generated definition]." . [] oboInOwl:source "PMID:17051153" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0003500 ; owl:annotatedTarget obo:NCBITaxon_9775 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003500 ; owl:annotatedTarget "blood vessel of cornea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003500 ; owl:annotatedTarget "cornea blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "A blood vessel that is part of a retina [Automatically generated definition]." . _:genid128029 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "blood vessel of inner layer of eyeball" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "blood vessel of retina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "blood vessel of tunica interna of eyeball" . _:genid128032 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "inner layer of eyeball blood vessel" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "retinal blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003501 ; owl:annotatedTarget "tunica interna of eyeball blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003502 ; owl:annotatedTarget "A blood vessel that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003502 ; owl:annotatedTarget "EMAPA:37236" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003502 ; owl:annotatedTarget "blood vessel of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003502 ; owl:annotatedTarget "blood vessel of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003502 ; owl:annotatedTarget "neck (volume) blood vessel" . (obo:UBERON_0001981 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 ] ) . _:genid128048 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003503 ; owl:annotatedTarget "A blood vessel that is part of a leg [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003503 ; owl:annotatedTarget "blood vessel of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003504 ; owl:annotatedTarget "A blood vessel that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003504 ; owl:annotatedTarget "apparatus respiratorius blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003504 ; owl:annotatedTarget "blood vessel of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003504 ; owl:annotatedTarget "blood vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003505 ; owl:annotatedTarget "A blood vessel that is part of a trachea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003505 ; owl:annotatedTarget "blood vessel of trachea" . _:genid128068 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "A blood vessel that is part of a chest [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "EMAPA:37239" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "anterior thoracic region blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "anterolateral part of thorax blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "blood vessel of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "blood vessel of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "blood vessel of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "blood vessel of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003506 ; owl:annotatedTarget "front of thorax blood vessel" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000657 ; owl:annotatedTarget obo:CL_0000017 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003507 ; owl:annotatedTarget "A blood vessel that is part of an arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003507 ; owl:annotatedTarget "EMAPA:37293" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003507 ; owl:annotatedTarget "blood vessel of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "A blood vessel that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "EMAPA:37302" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000657 ; owl:annotatedTarget "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of digit of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of digitus pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of foot digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of terminal segment of free lower limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "blood vessel of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "digit of foot blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "digit of terminal segment of free lower limb blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "digitus pedis blood vessel" . [] oboInOwl:hasDbXref "MA:0000645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "foot digit blood vessel" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "meso-ribitol" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000667 ; owl:annotatedTarget "An extracellular matrix secreting cell that secretes collagen." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "hind limb digit blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "terminal segment of free lower limb digit blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "toe blood vessel" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003508 ; owl:annotatedTarget "foot digit blood vessel" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003509 ; owl:annotatedTarget "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "ISBN:0721662544", "MESH:D020286", "PMID:16807374", "PMID:17986482", "PMID:20024907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000669 ; owl:annotatedTarget "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003510 ; owl:annotatedTarget "A blood vessel that is part of a eyelid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003510 ; owl:annotatedTarget "EMAPA:37388" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003510 ; owl:annotatedTarget "blepharon blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003510 ; owl:annotatedTarget "blood vessel of blepharon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003510 ; owl:annotatedTarget "blood vessel of eyelid" . [] oboInOwl:hasDbXref "PMID:17986482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000669 ; owl:annotatedTarget "ARC" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003511 ; owl:annotatedTarget "A blood vessel that is part of a iris [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003511 ; owl:annotatedTarget "EMAPA:37387" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003511 ; owl:annotatedTarget "blood vessel of iris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003512 ; owl:annotatedTarget "A blood vessel that is part of a lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003512 ; owl:annotatedTarget "blood vessel of lung" . [] oboInOwl:hasDbXref "EMAPA:32867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003512 ; owl:annotatedTarget "pulmonary vascular element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003513 ; owl:annotatedTarget "A blood vessel that is part of a trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003513 ; owl:annotatedTarget "EMAPA:37237" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003513 ; owl:annotatedTarget "blood vessel of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003513 ; owl:annotatedTarget "blood vessel of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003513 ; owl:annotatedTarget "torso blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003514 ; owl:annotatedTarget "A blood vessel that is part of a limb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003514 ; owl:annotatedTarget "blood vessel of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "A blood vessel that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "EMAPA:37292" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "anteriormost limb blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "blood vessel of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "blood vessel of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "blood vessel of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "blood vessel of upper extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "fore limb blood vessel" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003515 ; owl:annotatedTarget "wing blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "A blood vessel that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "EMAPA:37298" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "blood vessel of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "blood vessel of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "blood vessel of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003516 ; owl:annotatedTarget "hind limb blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003517 ; owl:annotatedTarget "A blood vessel that is part of a kidney [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003517 ; owl:annotatedTarget "blood vessel of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003517 ; owl:annotatedTarget "renal blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "EMAPA:37240" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "blood vessel of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "blood vessel of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "blood vessel of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "blood vessel of pectoral cavity" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget obo:CL_0000039 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "blood vessel of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "cavity of chest blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "cavity of thorax blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "chest cavity blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003519 ; owl:annotatedTarget "pectoral cavity blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003520 ; owl:annotatedTarget "A blood vessel that is part of a pelvis [Automatically generated definition]." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "ribitol" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget obo:CL_0000219 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003520 ; owl:annotatedTarget "EMAPA:37244" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003520 ; owl:annotatedTarget "blood vessel of pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003521 ; owl:annotatedTarget "A blood vessel that is part of a foot [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003521 ; owl:annotatedTarget "EMAPA:37301" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003521 ; owl:annotatedTarget "blood vessel of foot" . [] oboInOwl:hasDbXref "MA:0000642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003521 ; owl:annotatedTarget "foot blood vessel" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:1381289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000670 ; owl:annotatedTarget "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "A blood vessel that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "EMAPA:37297" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "blood vessel of digit of terminal segment of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "blood vessel of terminal segment of free upper limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "digit of terminal segment of free upper limb blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "finger blood vessel" . [] oboInOwl:hasDbXref "MA:0000621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "hand digit blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "terminal segment of free upper limb digit blood vessel" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003522 ; owl:annotatedTarget "hand digit blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003523 ; owl:annotatedTarget "A blood vessel that is part of a manus [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003523 ; owl:annotatedTarget "EMAPA:37296" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003523 ; owl:annotatedTarget "blood vessel of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003523 ; owl:annotatedTarget "blood vessel of manus" . [] oboInOwl:hasDbXref "MA:0000618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003523 ; owl:annotatedTarget "hand blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003524 ; owl:annotatedTarget "A blood vessel that is part of a tail [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003524 ; owl:annotatedTarget "blood vessel of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003524 ; owl:annotatedTarget "blood vessel of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003524 ; owl:annotatedTarget "post-vent region blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "A capillary that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "EMAPA:37574" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "apparatus respiratorius blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "apparatus respiratorius capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "apparatus respiratorius capillary vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "blood capillary of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "blood capillary of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "capillary of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "capillary of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "capillary vessel of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "capillary vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "respiratory system blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003526 ; owl:annotatedTarget "respiratory system capillary vessel" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget _:genid129336 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "A capillary that is part of a kidney [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "blood capillary of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "capillary of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "capillary vessel of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "kidney blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "kidney capillary vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003527 ; owl:annotatedTarget "renal capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "A gray matter that is part of a brain [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Cerebral_Gray_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "UMLS:C1707348" . [] oboInOwl:hasDbXref "MA:0000810" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "brain grey matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "brain grey substance" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "gray matter of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "grey matter of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003528 ; owl:annotatedTarget "grey substance of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "EMAPA:37581" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "apparatus respiratorius endothelium of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "apparatus respiratorius lymph vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "apparatus respiratorius lymphatic vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "endothelium of lymph vessel of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "endothelium of lymph vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "lymph vessel endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "lymph vessel endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "lymphatic vessel endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "lymphatic vessel endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "respiratory system endothelium of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "respiratory system lymph vessel endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003529 ; owl:annotatedTarget "respiratory system lymphatic vessel endothelium" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "(2R,3s,4S)-pentane-1,2,3,4,5-pentol" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "A zone of skin that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "UMLS:C1708089" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "digit of foot skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "digit of terminal segment of free lower limb skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "digitus pedis skin" . [] oboInOwl:hasDbXref "MA:0000650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "foot digit skin" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "hind limb digit skin" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000680 ; owl:annotatedTarget "A non-terminally differentiated cell that is capable of developing into a muscle cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of digit of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of digitus pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of foot digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of terminal segment of free lower limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "skin of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "terminal segment of free lower limb digit skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "toe skin" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003530 ; owl:annotatedTarget "foot digit skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "A zone of skin that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Skin_of_the_Upper_Limb_and_Shoulder" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "UMLS:C0222212" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "anteriormost limb skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "fore limb skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "skin of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "skin of forelimb" . [] oboInOwl:hasDbXref "FMA:23101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "skin of upper limb" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000681 ; owl:annotatedTarget "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." . [] oboInOwl:hasDbXref "FMA:23101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "upper limb skin" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003531 ; owl:annotatedTarget "wing skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "A zone of skin that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Skin_of_the_Lower_Limb_and_Hip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "UMLS:C0222268" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "hind limb skin" . [] oboInOwl:hasDbXref "FMA:23102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "lower limb skin" . [] oboInOwl:hasDbXref "GOC:tfm", "JB:jb", "PMID:15153415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000696 ; owl:annotatedTarget "A cell that stores and secretes pancreatic polypeptide hormone." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "skin of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "skin of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "skin of lower extremity" . [] oboInOwl:hasDbXref "FMA:23102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003532 ; owl:annotatedTarget "skin of lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "A zone of skin that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_Skin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "UMLS:C1708318" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "digit of hand skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "digit of terminal segment of free upper limb skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "digitus manus skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "finger skin" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "fore limb digit skin" . [] oboInOwl:hasDbXref "MA:0000626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "hand digit skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of digit of terminal segment of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of digitus manus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of hand digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "skin of terminal segment of free upper limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "terminal segment of free upper limb digit skin" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003533 ; owl:annotatedTarget "hand digit skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003534 ; owl:annotatedTarget "A zone of skin that is part of a tail [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003534 ; owl:annotatedTarget "post-vent region skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003534 ; owl:annotatedTarget "skin of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003534 ; owl:annotatedTarget "skin of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003535 ; owl:annotatedTarget "A nerve trunk that is part of a vagus nerve." . [] oboInOwl:hasDbXref "FMA:6221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003535 ; owl:annotatedTarget "trunk of vagus nerve" . [] oboInOwl:hasDbXref "EMAPA:17272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003535 ; owl:annotatedTarget "vagal X nerve trunk" . _:genid128379 oboInOwl:hasDbXref "EMAPA:17272" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003535 ; owl:annotatedTarget "vagal nerve trunk" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CHEBI_37395 . [] oboInOwl:hasDbXref "FMA:6221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003535 ; owl:annotatedTarget "vagus neural trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003538 ; owl:annotatedTarget "A bronchiole that is part of a right lung [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Right_Lung_Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003538 ; owl:annotatedTarget "UMLS:C0225670" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003538 ; owl:annotatedTarget "bronchiole of right lung" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000710 ; owl:annotatedTarget "Epithelial cells derived from neural plate and neural crest." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003539 ; owl:annotatedTarget "A bronchiole that is part of a left lung [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Left_Lung_Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003539 ; owl:annotatedTarget "UMLS:C0225674" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003539 ; owl:annotatedTarget "bronchiole of left lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003540 ; owl:annotatedTarget "A terminal bronchiole that is part of a right lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "Adonitol" . [] oboInOwl:source "ncithesaurus:Right_Lung_Terminal_Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003540 ; owl:annotatedTarget "UMLS:C1709961" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003540 ; owl:annotatedTarget "bronchiolus terminalis of right lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003540 ; owl:annotatedTarget "right lung bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003540 ; owl:annotatedTarget "terminal bronchiole of right lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003541 ; owl:annotatedTarget "A terminal bronchiole that is part of a left lung [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Left_Lung_Terminal_Bronchiole" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003541 ; owl:annotatedTarget "UMLS:C1708675" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003541 ; owl:annotatedTarget "bronchiolus terminalis of left lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003541 ; owl:annotatedTarget "left lung bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003541 ; owl:annotatedTarget "terminal bronchiole of left lung" . [] oboInOwl:hasDbXref "MP:0008026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." . [] oboInOwl:source "ncithesaurus:Brain_White_Matter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "UMLS:C1706995" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "brain white matter of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "brain white substance" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "white matter of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "white matter of neuraxis of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003544 ; owl:annotatedTarget "white substance of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "A meninx that is part of a brain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000013" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "Meninges that are part of the brain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000013" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "brain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "meninges of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003547 ; owl:annotatedTarget "meninx of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003548 ; owl:annotatedTarget "A meninx that is part of a forebrain [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003548 ; owl:annotatedTarget "EMAPA:37543" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003548 ; owl:annotatedTarget "forebrain meninx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003548 ; owl:annotatedTarget "meninges of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003548 ; owl:annotatedTarget "meninx of forebrain" . [] oboInOwl:hasDbXref "MP:0009026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "The fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000470" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pia+mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "The innermost of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000470" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Brain_Pia_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "UMLS:C1706994" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "brain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "pia mater of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003549 ; owl:annotatedTarget "pia mater of neuraxis of brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003550 ; owl:annotatedTarget "A pia mater that is part of a forebrain [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003550 ; owl:annotatedTarget "EMAPA:37546" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003550 ; owl:annotatedTarget "forebrain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003550 ; owl:annotatedTarget "pia mater of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003550 ; owl:annotatedTarget "pia mater of neuraxis of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "A pia mater that is part of a midbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000467" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "Pia mater that is part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000467" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "midbrain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "pia mater of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "pia mater of neuraxis of midbrain" . [] oboInOwl:hasDbXref "VHOG:0000467" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003551 ; owl:annotatedTarget "mesencephalon pia mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "A pia mater that is part of a telencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000476" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "Pia mater that is part of the telencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000476" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "pia mater of neuraxis of telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "pia mater of telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003552 ; owl:annotatedTarget "telencephalon pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "A pia mater that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000723 ; owl:annotatedTarget obo:CL_0000034 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000475" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "Pia mater that is part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000475" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "between brain pia mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "between brain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "diencephalon pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "interbrain pia mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "interbrain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "mature diencephalon pia mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "mature diencephalon pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of between brain" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "D-Adonitol" . [] oboInOwl:hasDbXref "GO:0048103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000723 ; owl:annotatedTarget "A stem cell that can give rise to cell types of the body other than those of the germ-line." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of neuraxis of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of neuraxis of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of neuraxis of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003553 ; owl:annotatedTarget "pia mater of neuraxis of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "A pia mater that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000466" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "Pia mater that is part of the hindbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000466" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "hindbrain pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "pia mater of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "pia mater of neuraxis of hindbrain" . [] oboInOwl:hasDbXref "VHOG:0000466" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003554 ; owl:annotatedTarget "rhombencephalon pia mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "A pia mater that is part of a spinal cord [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000468" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/pia+mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "The innermost of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000468" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Spinal_Cord_Pia_Mater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "UMLS:C1710148" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "pia mater of neuraxis of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "pia mater of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003555 ; owl:annotatedTarget "spinal cord pia mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "An arachnoid mater that is part of a forebrain [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "EMAPA:37544" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "arachnoid mater of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "arachnoid mater of neuraxis of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "arachnoid of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "forebrain arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003556 ; owl:annotatedTarget "forebrain arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "An arachnoid mater that is part of a midbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000233" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "Arachnoid mater that is part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000233" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "arachnoid mater of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "arachnoid mater of neuraxis of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "arachnoid of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "midbrain arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "midbrain arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "VHOG:0000233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003557 ; owl:annotatedTarget "mesencephalon arachnoid mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "An arachnoid mater that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000231" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "Arachnoid mater that is part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000231" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of neuraxis of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of neuraxis of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of neuraxis of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid mater of neuraxis of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid of diencephalon" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000737 ; owl:annotatedTarget "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "arachnoid of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "between brain arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "between brain arachnoid mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "between brain arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "diencephalon arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "diencephalon arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "interbrain arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "interbrain arachnoid mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "interbrain arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "mature diencephalon arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "mature diencephalon arachnoid mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003558 ; owl:annotatedTarget "mature diencephalon arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "An arachnoid mater that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000236" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "Arachnoid mater that is part of the hindbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000236" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "arachnoid mater of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "arachnoid mater of neuraxis of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "arachnoid of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "hindbrain arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "hindbrain arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "VHOG:0000236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003559 ; owl:annotatedTarget "rhombencephalon arachnoid mater" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "D-Ribitol" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "An arachnoid mater that is part of a spinal cord [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000234" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/arachnoid+mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "The middle membrane of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000234" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "arachnoid mater of neuraxis of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "arachnoid mater of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "arachnoid of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "spinal cord arachnoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003560 ; owl:annotatedTarget "spinal cord arachnoid mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003561 ; owl:annotatedTarget "A dura mater that is part of a forebrain." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003561 ; owl:annotatedTarget "EMAPA:37545" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003561 ; owl:annotatedTarget "dura mater of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003561 ; owl:annotatedTarget "dura mater of neuraxis of forebrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003561 ; owl:annotatedTarget "forebrain dura mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "A dura mater that is part of a midbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000410" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "Dura mater that is part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000410" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "dura mater of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "dura mater of neuraxis of midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "midbrain dura mater of neuraxis" . [] oboInOwl:hasDbXref "VHOG:0000410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003562 ; owl:annotatedTarget "mesencephalon dura mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003563 ; owl:annotatedTarget "A dura mater that is part of a telencephalon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003563 ; owl:annotatedTarget "dura mater of neuraxis of telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003563 ; owl:annotatedTarget "dura mater of telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003563 ; owl:annotatedTarget "telencephalon dura mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "A dura mater that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000258" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "Dura mater that is part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000258" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "between brain dura mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "between brain dura mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "diencephalon dura mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of neuraxis of between brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of neuraxis of diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of neuraxis of interbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "dura mater of neuraxis of mature diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "interbrain dura mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "interbrain dura mater of neuraxis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "mature diencephalon dura mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003564 ; owl:annotatedTarget "mature diencephalon dura mater of neuraxis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000738 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "A dura mater that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000409" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "Dura mater that is part of the hindbrain. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000409" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "dura mater of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "dura mater of neuraxis of hindbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "hindbrain dura mater of neuraxis" . [] oboInOwl:hasDbXref "VHOG:0000409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003565 ; owl:annotatedTarget "rhombencephalon dura mater" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000738 ; owl:annotatedTarget "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "A portion of connective tissue that is part of a head [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "adult head connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "adult head portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "adult head textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "connective tissue of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "connective tissue of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "head portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "head textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "portion of connective tissue of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "portion of connective tissue of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "textus connectivus of adult head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003566 ; owl:annotatedTarget "textus connectivus of head" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000740 ; owl:annotatedTarget "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "abdomen portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "abdomen textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "connective tissue of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "portion of connective tissue of abdomen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003567 ; owl:annotatedTarget "textus connectivus of abdomen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15963 ; owl:annotatedTarget "L-ribitol" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "A portion of connective tissue that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "EMAPA:37250" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "connective tissue of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "connective tissue of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "neck (volume) connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "neck (volume) portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "neck (volume) textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "neck portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "neck textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "portion of connective tissue of neck" . [] oboInOwl:hasDbXref "ISBN:0195088433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000745 ; owl:annotatedTarget "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "portion of connective tissue of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "textus connectivus of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003568 ; owl:annotatedTarget "textus connectivus of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "A portion of connective tissue that is part of a leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "EMAPA:37324" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "connective tissue of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "leg portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "leg textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "portion of connective tissue of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003569 ; owl:annotatedTarget "textus connectivus of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "apparatus respiratorius connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "apparatus respiratorius portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "apparatus respiratorius textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "connective tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "connective tissue of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "portion of connective tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "portion of connective tissue of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "respiratory system portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "respiratory system textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "textus connectivus of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003570 ; owl:annotatedTarget "textus connectivus of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003571 ; owl:annotatedTarget "A portion of connective tissue that is part of a trachea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003571 ; owl:annotatedTarget "connective tissue of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003571 ; owl:annotatedTarget "connective tissue of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "A portion of connective tissue that is part of a chest [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "EMAPA:37254" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterior thoracic region connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterior thoracic region portion of connective tissue" . _:genid128756 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterior thoracic region textus connectivus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterolateral part of thorax connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterolateral part of thorax portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "anterolateral part of thorax textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "chest portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "chest textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "connective tissue of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "connective tissue of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "connective tissue of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "connective tissue of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "front of thorax connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "front of thorax portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "front of thorax textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "portion of connective tissue of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "portion of connective tissue of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "portion of connective tissue of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "portion of connective tissue of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "textus connectivus of anterior thoracic region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "textus connectivus of anterolateral part of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "textus connectivus of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003572 ; owl:annotatedTarget "textus connectivus of front of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003573 ; owl:annotatedTarget "A portion of connective tissue that is part of an arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003573 ; owl:annotatedTarget "EMAPA:37316" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003574 ; owl:annotatedTarget "A portion of connective tissue that is part of a elbow [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003574 ; owl:annotatedTarget "EMAPA:37318" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003574 ; owl:annotatedTarget "connective tissue of cubital region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003574 ; owl:annotatedTarget "connective tissue of elbow" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003574 ; owl:annotatedTarget "textus connectivus of cubital region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003575 ; owl:annotatedTarget "A portion of connective tissue that is part of a wrist [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003575 ; owl:annotatedTarget "EMAPA:37320" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003575 ; owl:annotatedTarget "carpal region connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003575 ; owl:annotatedTarget "connective tissue of carpal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003575 ; owl:annotatedTarget "connective tissue of wrist" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003576 ; owl:annotatedTarget "A portion of connective tissue that is part of a hip [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003576 ; owl:annotatedTarget "EMAPA:37323" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003576 ; owl:annotatedTarget "connective tissue of hip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003576 ; owl:annotatedTarget "connective tissue of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003576 ; owl:annotatedTarget "connective tissue of regio coxae" . (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001465 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003577 ; owl:annotatedTarget "A portion of connective tissue that is part of a knee [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003577 ; owl:annotatedTarget "EMAPA:37326" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003577 ; owl:annotatedTarget "connective tissue of knee" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003577 ; owl:annotatedTarget "knee portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "A portion of connective tissue that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "EMAPA:37330" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "connective tissue of digit of foot" . [] oboInOwl:hasDbXref "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "connective tissue of digitus pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "connective tissue of foot digit" . _:genid128832 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "connective tissue of toe" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001612 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "digitus pedis textus connectivus" . [] oboInOwl:hasDbXref "MA:0000647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "foot digit connective tissue" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "hind limb digit connective tissue" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003578 ; owl:annotatedTarget "foot digit connective tissue" . [] oboInOwl:hasDbXref "GO:0048739" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000746 ; owl:annotatedTarget "cardiac muscle fiber" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "A portion of connective tissue that is part of a shoulder [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "EMAPA:37315" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "connective tissue of shoulder" . _:genid128845 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "portion of connective tissue of shoulder" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001612 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "shoulder portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "shoulder textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003579 ; owl:annotatedTarget "textus connectivus of shoulder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "EMAPA:37548" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "connective tissue of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "lower respiratory tract portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "lower respiratory tract textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "portion of connective tissue of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003580 ; owl:annotatedTarget "textus connectivus of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "A portion of connective tissue that is part of a eyelid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "EMAPA:37532" . [] oboInOwl:source "ncithesaurus:Eyelid_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "UMLS:C1707989" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "blepharon connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "connective tissue of blepharon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003581 ; owl:annotatedTarget "connective tissue of eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "A portion of connective tissue that is part of a nasopharynx [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "EMAPA:37682" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "connective tissue of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "connective tissue of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "connective tissue of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "nasal part of pharynx connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "nasal part of pharynx portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "nasal part of pharynx textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "nasopharynx portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "nasopharynx textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "portion of connective tissue of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "portion of connective tissue of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "portion of connective tissue of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "rhinopharynx connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "rhinopharynx portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "rhinopharynx textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "textus connectivus of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "textus connectivus of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003582 ; owl:annotatedTarget "textus connectivus of rhinopharynx" . _:genid128898 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "A portion of connective tissue that is part of a larynx [Automatically generated definition]." ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001653 . [] oboInOwl:source "ncithesaurus:Laryngeal_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "UMLS:C1708651" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "connective tissue of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "larynx portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "larynx textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "portion of connective tissue of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "textus connectivus of larynx" . [] oboInOwl:hasDbXref "EMAPA:35471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003583 ; owl:annotatedTarget "laryngeal connective tissue" . ( ) . [] oboInOwl:hasDbXref "MP:0009507", "https://github.com/obophenotype/uberon/issues/1151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "The fibrous supportive tissue of the mammary gland." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "connective tissue of lactiferous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "connective tissue of lobe of breast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "connective tissue of lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "connective tissue of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "lactiferous gland connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "lactiferous gland portion of connective tissue" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "lactiferous gland stroma" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "mammary gland stroma" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "mammary stroma" . [] oboInOwl:hasDbXref "FMA:74483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003584 ; owl:annotatedTarget "stroma of lactiferous gland" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget _:genid130003 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "A portion of connective tissue that is part of a dermis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "connective tissue of dermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "dermis portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "dermis textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "portion of connective tissue of dermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003585 ; owl:annotatedTarget "textus connectivus of dermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "A portion of connective tissue that is part of a trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "EMAPA:37252" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "connective tissue of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "connective tissue of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "portion of connective tissue of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "portion of connective tissue of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "textus connectivus of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "textus connectivus of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "torso connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "torso portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "torso textus connectivus" . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000748 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "trunk portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003586 ; owl:annotatedTarget "trunk textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "A portion of connective tissue that is part of a limb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "EMAPA:37313" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "connective tissue of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "limb portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "limb textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "portion of connective tissue of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003587 ; owl:annotatedTarget "textus connectivus of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "A portion of connective tissue that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "EMAPA:37314" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "connective tissue of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "connective tissue of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "connective tissue of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "connective tissue of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "connective tissue of upper extremity" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003588 ; owl:annotatedTarget "wing connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "A portion of connective tissue that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "EMAPA:37322" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "connective tissue of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "connective tissue of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "connective tissue of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "connective tissue of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003589 ; owl:annotatedTarget "hind limb connective tissue" . (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchus_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "UMLS:C1707052" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchi connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchi portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchi textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchial trunk connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchial trunk portion of connective tissue" . [] oboInOwl:hasDbXref "PMID:14689473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000752 ; owl:annotatedTarget "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchial trunk textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchus portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchus textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "connective tissue of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "connective tissue of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "connective tissue of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "portion of connective tissue of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "portion of connective tissue of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "portion of connective tissue of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "textus connectivus of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "textus connectivus of bronchial trunk" . _:genid129011 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "textus connectivus of bronchus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003504 . [] oboInOwl:hasDbXref "EMAPA:35193" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchial connective tissue" . _:genid129013 oboInOwl:hasDbXref "EMAPA:32690" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003592 ; owl:annotatedTarget "bronchial mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003526 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "EMAPA:37255" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of chest connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of chest portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of chest textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of thorax connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of thorax portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "cavity of thorax textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "chest cavity connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "chest cavity portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "chest cavity textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "connective tissue of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "connective tissue of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "connective tissue of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "connective tissue of pectoral cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "connective tissue of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "pectoral cavity connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "pectoral cavity portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "pectoral cavity textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "portion of connective tissue of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "portion of connective tissue of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "portion of connective tissue of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "portion of connective tissue of pectoral cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "portion of connective tissue of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "textus connectivus of cavity of chest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "textus connectivus of cavity of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "textus connectivus of chest cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "textus connectivus of pectoral cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "textus connectivus of thoracic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "thoracic cavity portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003593 ; owl:annotatedTarget "thoracic cavity textus connectivus" . _:genid129053 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "A portion of connective tissue that is part of a pelvis [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003469 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "EMAPA:37257" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "connective tissue of pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "pelvis portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "pelvis textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "portion of connective tissue of pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003594 ; owl:annotatedTarget "textus connectivus of pelvis" . (obo:UBERON_0002384 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "A portion of connective tissue that is part of a foot [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "EMAPA:37329" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "connective tissue of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "connective tissue of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "MA:0000644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "foot connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003595 ; owl:annotatedTarget "textus connectivus of pes" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003596 ; owl:annotatedTarget "A portion of connective tissue that is part of an ankle [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003596 ; owl:annotatedTarget "EMAPA:37328" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003596 ; owl:annotatedTarget "connective tissue of ankle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003596 ; owl:annotatedTarget "tarsal region connective tissue" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000762 ; owl:annotatedTarget obo:CL_0000763 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "A portion of connective tissue that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "EMAPA:37321" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "connective tissue of digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "connective tissue of digitus manus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "connective tissue of finger" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:16360205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000762 ; owl:annotatedTarget "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "connective tissue of hand digit" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "fore limb digit connective tissue" . [] oboInOwl:hasDbXref "MA:0000623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "hand digit connective tissue" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003597 ; owl:annotatedTarget "hand digit connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003598 ; owl:annotatedTarget "A portion of connective tissue that is part of a hand [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003598 ; owl:annotatedTarget "connective tissue of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003598 ; owl:annotatedTarget "connective tissue of terminal segment of free upper limb" . [] oboInOwl:hasDbXref "MA:0000620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003598 ; owl:annotatedTarget "hand connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "A portion of connective tissue that is part of a tail [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "connective tissue of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "connective tissue of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "portion of connective tissue of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "portion of connective tissue of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "post-vent region connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "post-vent region portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "post-vent region textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "tail portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "tail textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "textus connectivus of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003599 ; owl:annotatedTarget "textus connectivus of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003601 ; owl:annotatedTarget "A cartilage that is part of a neck [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003601 ; owl:annotatedTarget "EMAPA:37251" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003601 ; owl:annotatedTarget "cartilage of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003601 ; owl:annotatedTarget "cartilage of neck (volume)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003601 ; owl:annotatedTarget "neck (volume) cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003603 ; owl:annotatedTarget "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003603 ; owl:annotatedTarget "EMAPA:37547" . [] oboInOwl:source "ncithesaurus:Lower_Respiratory_Tract_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003603 ; owl:annotatedTarget "UMLS:C1708759" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003603 ; owl:annotatedTarget "cartilage of lower respiratory tract" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000763 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "J:97123", "MGI:smb", "MP:0003120", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "The ring-shaped cartilaginous structures that support the trachea." . [] oboInOwl:source "ncithesaurus:Trachea_Cartilage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "UMLS:C1710456" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilage of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilage of windpipe" . [] oboInOwl:hasDbXref "EMAPA:18699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilaginous ring of trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilaginous trachea cartilage" . [] oboInOwl:hasDbXref "FMA:7434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilago trachealis" . [] oboInOwl:hasDbXref "FMA:7434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "tracheal cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "windpipe cartilage" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000763 ; owl:annotatedTarget "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." . [] oboInOwl:hasDbXref "Wikipedia:Tracheal_rings" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilage of the trachea" . [] oboInOwl:hasDbXref "Wikipedia:Tracheal_rings" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "cartilagines tracheales" . [] oboInOwl:hasDbXref "Wikipedia:Tracheal_rings" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "ring of the trachea" . [] oboInOwl:hasDbXref "Wikipedia:Tracheal_rings" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003604 ; owl:annotatedTarget "tracheal ring" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "A skin gland that is part of a camera-type eye [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "EMAPA:37530" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000764 ; owl:annotatedTarget "A immature or mature cell in the lineage leading to and including erythrocytes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "camera-type eye skin gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "camera-type eye skin glands" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "camera-type eye skin glands set" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin gland of camera-type eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin gland of vertebrate eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin glands of camera-type eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin glands of vertebrate eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin glands set of camera-type eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "skin glands set of vertebrate eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "vertebrate eye skin gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "vertebrate eye skin glands" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003605 ; owl:annotatedTarget "vertebrate eye skin glands set" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003606 ; owl:annotatedTarget "A long bone that is part of a limb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003606 ; owl:annotatedTarget "long bone of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "A long bone that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "anteriormost limb long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "fore limb long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "long bone of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "long bone of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "long bone of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "long bone of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "long bone of upper extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "superior member long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "upper extremity long bone" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003607 ; owl:annotatedTarget "wing long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "A long bone that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "hind limb long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "inferior member long bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "Beilstein:1723800" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "long bone of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "long bone of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "long bone of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "long bone of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003608 ; owl:annotatedTarget "lower extremity long bone" . [] oboInOwl:hasDbXref "MP:0009862" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "adult aorta elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "adult aorta elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "adult aorta textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "aorta elastic connective tissue" . [] oboInOwl:hasDbXref "MP:0009862" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "aorta elastic lamina" . [] oboInOwl:hasDbXref "MP:0009862" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "aorta elastic laminae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "aorta textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "dorsal aorta elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "dorsal aorta elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "dorsal aorta textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic connective tissue of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic connective tissue of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic connective tissue of dorsal aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic connective tissue of trunk of aortic tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic tissue of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic tissue of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic tissue of dorsal aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "elastic tissue of trunk of aortic tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "textus connectivus elasticus of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "textus connectivus elasticus of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "textus connectivus elasticus of dorsal aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "textus connectivus elasticus of trunk of aortic tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "trunk of aortic tree elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "trunk of aortic tree elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003609 ; owl:annotatedTarget "trunk of aortic tree textus connectivus elasticus" . [] oboInOwl:hasDbXref "MP:0009863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." . [] oboInOwl:hasDbXref "MP:0009863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "cardiac elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "elastic connective tissue of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "elastic tissue of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "heart elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "heart textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003610 ; owl:annotatedTarget "textus connectivus elasticus of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "An elastic tissue that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "EMAPA:37579" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "apparatus respiratorius elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "apparatus respiratorius elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "apparatus respiratorius textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "elastic connective tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "elastic connective tissue of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "elastic tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "elastic tissue of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "respiratory system elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "respiratory system textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "textus connectivus elasticus of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003611 ; owl:annotatedTarget "textus connectivus elasticus of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "An elastic tissue that is part of a circulatory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "cardiovascular system elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "cardiovascular system textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "circulatory system elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "circulatory system elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "circulatory system textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "elastic connective tissue of cardiovascular system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "elastic connective tissue of circulatory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "elastic tissue of cardiovascular system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "elastic tissue of circulatory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "textus connectivus elasticus of cardiovascular system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003613 ; owl:annotatedTarget "textus connectivus elasticus of circulatory system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "Elastic tissue layer that lines a blood vessel layer." . [] oboInOwl:hasDbXref "MP:0006083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "elastic lamina" . [] oboInOwl:hasDbXref "MP:0006083" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "elastic laminae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "blood vessel elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "blood vessel textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "elastic connective tissue of blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "elastic tissue of blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "textus connectivus elasticus of blood vessel" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "vascular elastic lamina" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "vascular elastic laminae" . [] oboInOwl:hasDbXref "MP:0006083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003614 ; owl:annotatedTarget "vascular elastic tissue" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "CAS:6893-26-1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "Elastic tissue that is part of a lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "elastic connective tissue of lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "elastic tissue of lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "lung elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "lung textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "textus connectivus elasticus of lung" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003615 ; owl:annotatedTarget "pulmonary elastic fiber" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "An elastic tissue that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchus_Elastic_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "UMLS:C1707053" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchi elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchi elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchi textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchial trunk elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchial trunk elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchial trunk textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchus elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "bronchus textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic connective tissue of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic connective tissue of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic connective tissue of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic tissue of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic tissue of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "elastic tissue of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "textus connectivus elasticus of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "textus connectivus elasticus of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003616 ; owl:annotatedTarget "textus connectivus elasticus of bronchus" . _:genid129336 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "An elastic tissue that is part of a trachea [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006544 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "cartilaginous trachea elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "cartilaginous trachea elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "cartilaginous trachea textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic connective tissue of cartilaginous trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic connective tissue of vertebrate trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic connective tissue of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic tissue of cartilaginous trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic tissue of vertebrate trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "elastic tissue of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "textus connectivus elasticus of cartilaginous trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "textus connectivus elasticus of vertebrate trachea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "textus connectivus elasticus of windpipe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "vertebrate trachea elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "vertebrate trachea elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "vertebrate trachea textus connectivus elasticus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "windpipe elastic connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "windpipe elastic tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003617 ; owl:annotatedTarget "windpipe textus connectivus elasticus" . [] oboInOwl:hasDbXref "MP:0009873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "adult aorta tunica media" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "dorsal aorta tunica media" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "trunk of aortic tree tunica media" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "tunica media of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "tunica media of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "tunica media of dorsal aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003618 ; owl:annotatedTarget "tunica media of trunk of aortic tree" . [] oboInOwl:hasDbXref "MP:0009872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "adult aorta tunica intima" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "dorsal aorta tunica intima" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "trunk of aortic tree tunica intima" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "tunica intima of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "tunica intima of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "tunica intima of dorsal aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003619 ; owl:annotatedTarget "tunica intima of trunk of aortic tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "A phalanx that is part of a hand digit 1 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_1_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "UMLS:C1711344" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "fore limb digit 1 phalanx" . [] oboInOwl:hasDbXref "MA:0001389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "hand digit 1 phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "manual digit I phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "phalanx of hand digit 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "phalanx of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "thumb phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003620 ; owl:annotatedTarget "hand digit 1 phalanx" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "CAS:6893-26-1" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget _:genid130479 . [] oboInOwl:hasDbXref "Wikipedia:Index_finger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "2nd digit of the manus." . [] oboInOwl:hasScope "NCBITaxon:8782" ; oboInOwl:seeAlso "UBERON:0012261" ; oboInOwl:source "PMID:10220427", "PhenoscapeRCN" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." . [] oboInOwl:source "ncithesaurus:Hand_Digit_2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "UMLS:C0230388" . [] oboInOwl:hasDbXref "EMAPA:17432" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "digit 2 of fore-paw" . [] oboInOwl:hasDbXref "EHDAA2:0000517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "finger 2" . [] oboInOwl:hasDbXref "AAO:0010640" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "fore digit II" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "fore limb digit 2" . [] oboInOwl:hasDbXref "MA:0000455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "hand digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "manual digit II" . [] oboInOwl:hasDbXref "FMA:24946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "second digit of hand" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003622 ; owl:annotatedTarget "hand digit 2" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget _:genid130497 . [] oboInOwl:hasDbXref "Wikipedia:Middle_finger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "3rd digit of the manus." . [] oboInOwl:hasScope "NCBITaxon:8782" ; oboInOwl:seeAlso "UBERON:0012262" ; oboInOwl:source "PMID:10220427", "PhenoscapeRCN" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." . [] oboInOwl:source "ncithesaurus:Hand_Digit_3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "UMLS:C0230393" . [] oboInOwl:hasDbXref "EMAPA:17435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "digit 3 of fore-paw" . [] oboInOwl:hasDbXref "EHDAA2:0000523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "finger 3" . [] oboInOwl:hasDbXref "AAO:0010641" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "fore digit III" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "fore limb digit 3" . [] oboInOwl:hasDbXref "MA:0000456" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "hand digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "manual digit III" . [] oboInOwl:hasDbXref "FMA:24947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "third digit of hand" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "hand digit 3" . [] oboInOwl:hasDbXref "Wikipedia:Middle_finger" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "digitus medius" . [] oboInOwl:hasDbXref "EMAPA:17435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003623 ; owl:annotatedTarget "long finger" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget _:genid130517 . [] oboInOwl:hasDbXref "Wikipedia:Ring_finger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "4th digit of the manus." . [] oboInOwl:source "ncithesaurus:Hand_Digit_4" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "UMLS:C0230398" . [] oboInOwl:hasDbXref "EMAPA:17438" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "digit 4 of fore-paw" . [] oboInOwl:hasDbXref "EHDAA2:0000529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "finger 4" . [] oboInOwl:hasDbXref "AAO:0010642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "fore digit IV" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "fore limb digit 4" . [] oboInOwl:hasDbXref "FMA:24948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "fourth digit of hand" . [] oboInOwl:hasDbXref "MA:0000457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "hand digit 4" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "manual digit IV" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "hand digit 4" . [] oboInOwl:hasDbXref "Wikipedia:Ring_finger" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003624 ; owl:annotatedTarget "digitus annularis" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget _:genid130535 . [] oboInOwl:hasDbXref "Wikipedia:Little_finger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "5th digit of the manus." . [] oboInOwl:source "ncithesaurus:Hand_Digit_5" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "UMLS:C0230403" . [] oboInOwl:hasDbXref "EMAPA:17441" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "digit 5 of fore-paw" . [] oboInOwl:hasDbXref "FMA:24949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "fifth digit of hand" . [] oboInOwl:hasDbXref "EHDAA2:0000535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "finger 5" . [] oboInOwl:hasDbXref "AAO:0010643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "fore digit V" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "fore limb digit 5" . [] oboInOwl:hasDbXref "MA:0000458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "hand digit 5" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "manual digit V" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "hand digit 5" . [] oboInOwl:hasDbXref "Wikipedia:Little_finger" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "manual digitus V" . [] oboInOwl:hasDbXref "Wikipedia:Little_finger" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "manual digitus minimus" . [] oboInOwl:hasDbXref "Wikipedia:Little_finger" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003625 ; owl:annotatedTarget "manus quintus" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget _:genid130555 . [] oboInOwl:hasDbXref "Wikipedia:Hallux" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "1st digit of the hind autopod." . [] oboInOwl:source "ncithesaurus:Foot_Digit_1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "UMLS:C1708079" . [] oboInOwl:hasDbXref "EMAPA:17460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "digit 1 of hind-paw" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000765 ; owl:annotatedTarget obo:CL_0000764 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "digitus primus pedis" . [] oboInOwl:hasDbXref "MA:0000465" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "foot digit 1" . [] oboInOwl:hasDbXref "FMA:25047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "great toe" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "hallux" . [] oboInOwl:hasDbXref "FMA:25047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "hallux; digitus primus [I]" . [] oboInOwl:hasDbXref "AAO:0010644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "hind digit I" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "hind limb digit 1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "pedal digit I" . [] oboInOwl:hasDbXref "EHDAA2:0002037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "toe 1" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "foot digit 1" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "PMID:18174176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000765 ; owl:annotatedTarget "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." . [] oboInOwl:hasDbXref "Wikipedia:Dewclaw" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "hindlimb dewclaw" . [] oboInOwl:hasDbXref "BTO:0002349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "digitus primus (I) pedis" . [] oboInOwl:hasDbXref "EMAPA:17460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "first toe" . [] oboInOwl:hasDbXref "EMAPA:17460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003631 ; owl:annotatedTarget "large toe" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget _:genid130580 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "CAS:6893-26-1" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "2nd digit of the hind autopod." . [] oboInOwl:source "ncithesaurus:Foot_Digit_2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "UMLS:C1708081" . [] oboInOwl:hasDbXref "EMAPA:17463" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "digit 2 of hind-paw" . [] oboInOwl:hasDbXref "FMA:25048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "digitus secundus [ii]" . [] oboInOwl:hasDbXref "BTO:0002350" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "digitus secundus pedis" . [] oboInOwl:hasDbXref "MA:0000466" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "foot digit 2" . [] oboInOwl:hasDbXref "AAO:0010645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "hind digit II" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "hind limb digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "pedal digit II" . [] oboInOwl:hasDbXref "FMA:25048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "second digit of foot" . [] oboInOwl:hasDbXref "FMA:25048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "second toe" . [] oboInOwl:hasDbXref "EHDAA2:0002042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "toe 2" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "foot digit 2" . [] oboInOwl:hasDbXref "BTO:0002350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003632 ; owl:annotatedTarget "digitus secundus (II) pedis" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget _:genid130601 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "3rd digit of the hind autopod." . [] oboInOwl:source "ncithesaurus:Foot_Digit_3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "UMLS:C1708083" . [] oboInOwl:hasDbXref "EMAPA:17466" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "digit 3 of hind-paw" . [] oboInOwl:hasDbXref "BTO:0002351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "digitus tertius (III) pedis" . [] oboInOwl:hasDbXref "FMA:25051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "digitus tertius [iii]" . [] oboInOwl:hasDbXref "BTO:0002351" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "digitus tertius pedis" . [] oboInOwl:hasDbXref "MA:0000467" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "foot digit 3" . [] oboInOwl:hasDbXref "AAO:0010646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "hind digit III" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "hind limb digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "pedal digit III" . [] oboInOwl:hasDbXref "FMA:25051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "third digit of foot" . [] oboInOwl:hasDbXref "FMA:25051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "third toe" . [] oboInOwl:hasDbXref "EHDAA2:0002047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "toe 3" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003633 ; owl:annotatedTarget "foot digit 3" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "4th digit of the hind autopod." . [] oboInOwl:source "ncithesaurus:Foot_Digit_4" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "UMLS:C1708085" . [] oboInOwl:hasDbXref "EMAPA:17469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "digit 4 of hind-paw" . [] oboInOwl:hasDbXref "BTO:0002352" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "digitus quartis pedis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000766 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "FMA:25052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "digitus quartus [iv]" . [] oboInOwl:hasDbXref "MA:0000468" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "foot digit 4" . [] oboInOwl:hasDbXref "FMA:25052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "fourth digit of foot" . [] oboInOwl:hasDbXref "FMA:25052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "fourth toe" . [] oboInOwl:hasDbXref "AAO:0010656" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "hind digit IV" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "hind limb digit 4" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "pedal digit IV" . [] oboInOwl:hasDbXref "EHDAA2:0002052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "toe 4" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "foot digit 4" . [] oboInOwl:hasDbXref "BTO:0002352" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003634 ; owl:annotatedTarget "digitus quartus (IV) pedis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000766 ; owl:annotatedTarget "A cell of the monocyte, granulocyte, or mast cell lineage." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget _:genid130638 . [] oboInOwl:hasDbXref "Wikipedia:Fifth_toe", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "5th digit of the hind autopod." . [] oboInOwl:source "ncithesaurus:Foot_Digit_5" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "UMLS:C1708087" . [] oboInOwl:hasDbXref "EMAPA:17472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digit 5 of hind-paw" . [] oboInOwl:hasDbXref "Wikipedia:Fifth_toe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus minimus pedis" . [] oboInOwl:hasDbXref "FMA:25053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus minimus; digitus quintus [v]" . [] oboInOwl:hasDbXref "FMA:25053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus quintus [V]" . [] oboInOwl:hasDbXref "FMA:25053", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus quintus [V] pedis" . [] oboInOwl:hasDbXref "Wikipedia:Fifth_toe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus quintus pedis" . [] oboInOwl:hasDbXref "FMA:25053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:25053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "fifth toe" . [] oboInOwl:hasDbXref "MA:0000469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "foot digit 5" . [] oboInOwl:hasDbXref "AAO:0010658" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "hind digit V" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "hind limb digit 5" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "pedal digit V" . [] oboInOwl:hasDbXref "EHDAA2:0002057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "toe 5" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "foot digit 5" . [] oboInOwl:hasDbXref "BTO:0002353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003635 ; owl:annotatedTarget "digitus quintus (V) pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "A phalanx that is part of a hand digit 2 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_2_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "UMLS:C1708312" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd digit of hand digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd digit of hand long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd digit of hand phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "2 nd finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "digit long bone of 2 nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "digit long bone of 2 nd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "digit long bone of hand digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "digit long bone of second finger" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "fore limb digit 2 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "hand digit 2 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "hand digit 2 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001390" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "hand digit 2 phalanx" . [] oboInOwl:hasDbXref "FMA:35480" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "index finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "long bone of digit of 2 nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "long bone of digit of 2 nd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "long bone of digit of hand digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "long bone of digit of second finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "Gmelin:201189" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "manual digit II phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of 2 nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of 2 nd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of hand digit 2" . [] oboInOwl:hasDbXref "FMA:35480" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of index finger" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of manual digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "phalanx of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "second finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "second finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "second finger phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003636 ; owl:annotatedTarget "hand digit 2 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "A phalanx that is part of a hand digit 3 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_3_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "UMLS:C1708314" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd digit of hand digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd digit of hand long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd digit of hand phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "3 rd finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "digit long bone of 3 rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "digit long bone of 3 rd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "digit long bone of hand digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "digit long bone of third finger" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "fore limb digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "hand digit 3 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "hand digit 3 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "hand digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "long bone of digit of 3 rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "long bone of digit of 3 rd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "long bone of digit of hand digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "long bone of digit of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "manual digit III phalanx" . [] oboInOwl:hasDbXref "FMA:35483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "middle finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "phalanx of 3 rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "phalanx of 3 rd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "phalanx of hand digit 3" . [] oboInOwl:hasDbXref "FMA:35483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "phalanx of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "phalanx of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "third finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "third finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "third finger phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003637 ; owl:annotatedTarget "hand digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "A phalanx that is part of a hand digit 4 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_4_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "UMLS:C1708316" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th digit of hand digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th digit of hand long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th digit of hand phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "4 th finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "digit long bone of 4 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "digit long bone of 4 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "digit long bone of fourth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "digit long bone of hand digit 4" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "fore limb digit 4 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "fourth finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "fourth finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "fourth finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "hand digit 4 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "hand digit 4 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001392" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "hand digit 4 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "long bone of digit of 4 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "long bone of digit of 4 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "long bone of digit of fourth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "long bone of digit of hand digit 4" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "manual digit IV phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "phalanx of 4 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "phalanx of 4 th finger" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000767 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "phalanx of fourth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "phalanx of hand digit 4" . [] oboInOwl:hasDbXref "FMA:35486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:35486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "ring finger phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003638 ; owl:annotatedTarget "hand digit 4 phalanx" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D001491", "PMCID:PMC2626675", "PMID:11927641", "PMID:19741522", "PMID:21236338", "PMID:9933081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000767 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "A phalanx that is part of a hand digit 5 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Hand_Digit_5_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "UMLS:C1708317" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th digit of hand digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th digit of hand long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th digit of hand phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "5 th finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "digit long bone of 5 th digit of hand" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "Reaxys:1723800" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "digit long bone of 5 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "digit long bone of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "digit long bone of hand digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "fifth finger digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "fifth finger long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "fifth finger phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "fore limb digit 5 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "hand digit 5 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "hand digit 5 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "hand digit 5 phalanx" . [] oboInOwl:hasDbXref "FMA:35489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "little finger phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "long bone of digit of 5 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "long bone of digit of 5 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "long bone of digit of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "long bone of digit of hand digit 5" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "manual digit V phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of 5 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of 5 th finger" . [] oboInOwl:hasDbXref "FMA:35489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of hand digit 5" . [] oboInOwl:hasDbXref "FMA:35489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "phalanx of manual digitus minimus" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003639 ; owl:annotatedTarget "hand digit 5 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "A phalanx that is part of a foot digit 1 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_1_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "UMLS:C1708080" . [] oboInOwl:hasDbXref "FMA:32884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "big toe phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "digit long bone of foot digit 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "digit long bone of hallux" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "foot digit 1 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "foot digit 1 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001381" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "foot digit 1 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "hallux digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "hallux long bone of digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "hallux phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "hind limb digit 1 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "long bone of digit of foot digit 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "long bone of digit of hallux" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "pedal digit I phalanx" . [] oboInOwl:hasDbXref "FMA:32884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of big toe" . [] oboInOwl:hasDbXref "FMA:32884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of first digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of foot digit 1" . [] oboInOwl:hasDbXref "FMA:32884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of great toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of hallux" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "foot digit 1 phalanx" . [] oboInOwl:hasDbXref "FMA:32884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003640 ; owl:annotatedTarget "phalanx of first toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "A phalanx that is part of a foot digit 2 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_2_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "UMLS:C1708082" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "digit long bone of foot digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "foot digit 2 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "foot digit 2 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "foot digit 2 phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "hind limb digit 2 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "long bone of digit of foot digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "pedal digit II phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "phalanx of foot digit 2" . [] oboInOwl:hasDbXref "FMA:32899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "phalanx of second toe" . [] oboInOwl:hasDbXref "FMA:32899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "second toe phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003641 ; owl:annotatedTarget "foot digit 2 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "A phalanx that is part of a foot digit 3 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_3_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "UMLS:C1708084" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "digit long bone of foot digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "foot digit 3 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "foot digit 3 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001383" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "foot digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "hind limb digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "long bone of digit of foot digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "pedal digit III phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "phalanx of foot digit 3" . [] oboInOwl:hasDbXref "FMA:32900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "phalanx of third toe" . [] oboInOwl:hasDbXref "FMA:32900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "third toe phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003642 ; owl:annotatedTarget "foot digit 3 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003643 ; owl:annotatedTarget "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003643 ; owl:annotatedTarget "EMAPA:37565" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "(2R)-2-aminopentanedioic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003644 ; owl:annotatedTarget "An arterial blood vessel that is part of a kidney [Automatically generated definition]." . [] oboInOwl:hasDbXref "EMAPA:31436" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003644 ; owl:annotatedTarget "kidney arterial system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 1." . [] oboInOwl:source "Wikipedia:First_metacarpal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "The first metacarpal bone or the metacarpal bone of the thumb is the first bone of the thumb. It is connected to the trapezium of the carpus at the first carpometacarpal joint and to the proximal thumb phalanx at the first metacarpophalangeal joint[Wikipedia:First_metacarpal_bone]." . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone_Digit_1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "UMLS:C1708987" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "first digit of hand metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "first digit of hand metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "first metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "hand digit 1 metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "hand digit 1 metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal I" . [] oboInOwl:hasDbXref "MA:0001364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal bone digit 1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal bone of digit I" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal bone of first digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal bone of hand digit 1" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000771 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal bone of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal of first digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal of hand digit 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "metacarpal of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "thumb metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "thumb metacarpal bone" . [] oboInOwl:hasDbXref "EMAPA:19112" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003645 ; owl:annotatedTarget "forelimb digit 1 metacarpus" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMCID:PMC2626675", "PMID:10914487", "PMID:1662676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000771 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 2." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000853" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with the prepollex and carpal 2(1) or carpal 2+3(1+2) proximally and with the proximal phalanx of digit II(I) distally.[AAO]" . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone_Digit_2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "UMLS:C1708988" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "2 nd digit of hand metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "2 nd digit of hand metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "2 nd finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "2 nd finger metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "hand digit 2 metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "hand digit 2 metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal II" . [] oboInOwl:hasDbXref "MA:0001365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone of 2 nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone of 2 nd finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone of digit II" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone of hand digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal bone of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal of 2 nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal of 2 nd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal of hand digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "metacarpal of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "second finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "second finger metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "second metacarpal bone" . [] oboInOwl:hasDbXref "EMAPA:19114" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003646 ; owl:annotatedTarget "forelimb digit 2 metacarpus" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Third_metacarpal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 3[Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000854" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with carpal 3(2) proximally and with the proximal phalanx of digit III(II) distally.[AAO]" . [] oboInOwl:source "Wikipedia:Third_metacarpal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "The third metacarpal bone (metacarpal bone of the middle finger) is a little smaller than the second. The dorsal aspect of its base presents on its radial side a pyramidal eminence, the styloid process, which extends upward behind the capitate; immediately distal to this is a rough surface for the attachment of the extensor carpi radialis brevis muscle. The carpal articular facet is concave behind, flat in front, and articulates with the capitate. On the radial side is a smooth, concave facet for articulation with the second metacarpal, and on the ulnar side two small oval facets for the fourth metacarpal[Wikipedia:Third_metacarpal_bone]." . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone_Digit_3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "UMLS:C1708989" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "3 rd digit of hand metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "3 rd digit of hand metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "3 rd finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "3 rd finger metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "hand digit 3 metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "hand digit 3 metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal III" . [] oboInOwl:hasDbXref "MA:0001366" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone of 3 rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone of 3 rd finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone of digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone of hand digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal bone of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal of 3 rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal of 3 rd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal of hand digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "metacarpal of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "third finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "third finger metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "third metacarpal bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "forelimb cannon bone" . [] oboInOwl:hasDbXref "EMAPA:19116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003647 ; owl:annotatedTarget "forelimb digit 3 metacarpus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 4." . [] oboInOwl:source "Wikipedia:Fourth_metacarpal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "The fourth metacarpal bone (metacarpal bone of the ring finger) is shorter and smaller than the third. The base is small and quadrilateral; its superior surface presents two facets, a large one medially for articulation with the hamate, and a small one laterally for the capitate. On the radial side are two oval facets, for articulation with the third metacarpal; and on the ulnar side a single concave facet, for the fifth metacarpal[Wikipedia:Fourth_metacarpal_bone]." . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone_Digit_4" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "UMLS:C1708990" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "4 th digit of hand metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "4 th digit of hand metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "4 th finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "4 th finger metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "fourth finger metacarpal" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "D-Glutamic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000775 ; owl:annotatedTarget obo:CL_0000094 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "fourth finger metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "fourth metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "hand digit 4 metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "hand digit 4 metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal IV" . [] oboInOwl:hasDbXref "MA:0001367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone digit 4" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone of 4 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone of 4 th finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone of digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone of fourth finger" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000775 ; owl:annotatedTarget "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal bone of hand digit 4" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal of 4 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal of 4 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal of fourth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "metacarpal of hand digit 4" . [] oboInOwl:hasDbXref "EMAPA:19118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003648 ; owl:annotatedTarget "forelimb digit 4 metacarpus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 5." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000855" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that articulates with carpal 5(4) proximally and with the proximal phalanx of digit V(IV) distally.[AAO]" . [] oboInOwl:source "Wikipedia:Fifth_metacarpal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "The fifth metacarpal bone (metacarpal bone of the little finger or pinky finger) is the most lateral metacarpal[Wikipedia:Fifth_metacarpal_bone]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "FMA also has FMA:36782 ! Bone of fifth metacarpal bone" . [] oboInOwl:source "ncithesaurus:Metacarpal_Bone_Digit_5" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "UMLS:C1711224" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "5 th digit of hand metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "5 th digit of hand metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "5 th finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "5 th finger metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "fifth finger metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "fifth finger metacarpal bone" . [] oboInOwl:hasDbXref "FMA:23903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "fifth metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "hand digit 5 metacarpal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "hand digit 5 metacarpal bone" . [] oboInOwl:hasDbXref "MA:0001368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone of 5 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone of 5 th finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone of digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal bone of hand digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal of 5 th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal of 5 th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "metacarpal of hand digit 5" . [] oboInOwl:hasDbXref "EMAPA:19120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003649 ; owl:annotatedTarget "forelimb digit 5 metacarpus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 1." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000925" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with the prepollex and tarsal 1 proximally and with the proximal phalanx of digit I distally.[AAO]" . [] oboInOwl:source "Wikipedia:First_metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "The first metatarsal bone is the bone in the body of the foot just behind the big toe. It is remarkable for its great thickness, and is the shortest of the metatarsal bones. The body is strong, and of well-marked prismoid form. The base presents, as a rule, no articular facets on its sides, but occasionally on the lateral side there is an oval facet, by which it articulates with the second metatarsal. Its proximal articular surface is of large size and kidney-shaped; its circumference is grooved, for the tarsometatarsal ligaments, and medially gives insertion to part of the tendon of the Tibialis anterior; its plantar angle presents a rough oval prominence for the insertion of the tendon of the Peronæus longus. The head is large; on its plantar surface are two grooved facets, on which glide sesamoid bones; the facets are separated by a smooth elevation[Wikipedia:First_metatarsal_bone]." . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone_Digit_1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "UMLS:C1708999" . [] oboInOwl:hasDbXref "FMA:24502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "first metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "foot digit 1 metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "hallux metatarsal bone" . [] oboInOwl:hasDbXref "AAO:0000925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "metatarsal I" . [] oboInOwl:hasDbXref "MA:0001369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "metatarsal bone digit 1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "metatarsal bone of digit I" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "metatarsal bone of foot digit 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "metatarsal bone of hallux" . [] oboInOwl:hasDbXref "EMAPA:19123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003650 ; owl:annotatedTarget "hindlimb digit 1 metatarsus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 2." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000926" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 2 proximally and with the proximal phalanx of digit II distally.[AAO]" . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone_Digit_2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "UMLS:C1709000" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "foot digit 2 metatarsal bone" . [] oboInOwl:hasDbXref "AAO:0000926" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "metatarsal II" . [] oboInOwl:hasDbXref "MA:0001370" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "metatarsal bone digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "metatarsal bone of digit II" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "metatarsal bone of foot digit 2" . [] oboInOwl:hasDbXref "FMA:24503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "second metatarsal bone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000782 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "EMAPA:19125" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003651 ; owl:annotatedTarget "hindlimb digit 2 metatarsus" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Third_metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 3[Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000927" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 3 proximally and with the proximal phalanx of digit III distally.[AAO]" . [] oboInOwl:source "Wikipedia:Third_metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "The third metatarsal bone articulates proximally, by means of a triangular smooth surface, with the third cuneiform; medially, by two facets, with the second metatarsal; and laterally, by a single facet, with the fourth metatarsal. This last facet is situated at the dorsal angle of the base[Wikipedia:Third_metatarsal_bone]." . [] oboInOwl:hasDbXref "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000782 ; owl:annotatedTarget "A dendritic cell of the myeloid lineage." . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone_Digit_3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "UMLS:C1709001" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "foot digit 3 metatarsal bone" . [] oboInOwl:hasDbXref "AAO:0000927" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "metatarsal III" . [] oboInOwl:hasDbXref "MA:0001371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "metatarsal bone digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "metatarsal bone of digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "metatarsal bone of foot digit 3" . [] oboInOwl:hasDbXref "FMA:24504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "third metatarsal bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "hindlimb cannon bone" . [] oboInOwl:hasDbXref "EMAPA:19127" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003652 ; owl:annotatedTarget "hindlimb digit 3 metatarsal" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "D-glutamic acid" . _:genid130003 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342, obo:UBERON_0010560 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 4." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000928" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 4 or the distal head of the tibiale-fibulare proximally and with the proximal phalanx of digit IV distally.[AAO]" . [] oboInOwl:source "Wikipedia:Fourth_metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "The fourth metatarsal bone is smaller in size than the third; its base presents an oblique quadrilateral surface for articulation with the cuboid; a smooth facet on the medial side, divided by a ridge into an anterior portion for articulation with the third metatarsal, and a posterior portion for articulation with the third cuneiform; on the lateral side a single facet, for articulation with the fifth metatarsal[Wikipedia:Fourth_metatarsal_bone]." . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone_Digit_4" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "UMLS:C1709002" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "foot digit 4 metatarsal bone" . [] oboInOwl:hasDbXref "FMA:24505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "fourth metatarsal bone" . [] oboInOwl:hasDbXref "AAO:0000928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "metatarsal IV" . [] oboInOwl:hasDbXref "MA:0001372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "metatarsal bone digit 4" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "metatarsal bone of digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "metatarsal bone of foot digit 4" . [] oboInOwl:hasDbXref "EMAPA:19129" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003653 ; owl:annotatedTarget "hindlimb digit 4 metatarsus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 5." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000929" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 5 or the distal head of the tibiale-fibulare proximally and with the proximal phalanx of digit V distally.[AAO]" . [] oboInOwl:source "Wikipedia:Fifth_metatarsal_bone" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "The fifth metatarsal bone is recognized by a rough eminence, the tuberosity, on the lateral side of its base. The base articulates behind, by a triangular surface cut obliquely in a transverse direction, with the cuboid; and medially, with the fourth metatarsal. On the medial part of its dorsal surface is inserted the tendon of the Peronæus tertius and on the dorsal surface of the tuberosity that of the Peronæus brevis. A strong band of the plantar aponeurosis connects the projecting part of the tuberosity with the lateral process of the tuberosity of the calcaneus. The plantar surface of the base is grooved for the tendon of the Abductor digiti quinti, and gives origin to the Flexor digiti quinti brevis. The base of the metatarsal is often injured and a particularly notorious fracture is the Jones fracture. When the tuberosity is broken, it is called a pseudo-Jones fracture or a dancer's fracture. This is a common fracture of the fifth metatarsal. Stress fractures are common in the fifth metatarsal among athletes[Wikipedia:Fifth_metatarsal_bone]." . [] oboInOwl:source "ncithesaurus:Metatarsal_Bone_Digit_5" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "UMLS:C1709003" . [] oboInOwl:hasDbXref "FMA:24506" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "fifth metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "foot digit 5 metatarsal bone" . [] oboInOwl:hasDbXref "AAO:0000929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "metatarsal V" . [] oboInOwl:hasDbXref "MA:0001373" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "metatarsal bone digit 5" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "metatarsal bone of digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "metatarsal bone of foot digit 5" . [] oboInOwl:hasDbXref "EMAPA:19131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003654 ; owl:annotatedTarget "hindlimb digit 5 metatarsus" . [] oboInOwl:hasDbXref "Wikipedia:Molar_(tooth)", "https://github.com/obophenotype/uberon/issues/221" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003655 ; owl:annotatedTarget "Molars are the rearmost and most complicated kind of tooth in most mammals." . [] oboInOwl:source "ncithesaurus:Molar_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003655 ; owl:annotatedTarget "UMLS:C0026367" . [] oboInOwl:hasDbXref "Wikipedia:Molar_(tooth)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003655 ; owl:annotatedTarget "dens molaris" . [] oboInOwl:hasDbXref "BTO:0001759" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003655 ; owl:annotatedTarget "molaris" . [] oboInOwl:hasDbXref "MA:0000350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003655 ; owl:annotatedTarget "molar" . [] oboInOwl:source "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget obo:UBERON_0013630 . [] oboInOwl:notes "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget _:genid131128 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget "A bone that is part of a mesopodial skeleton." . [] oboInOwl:source "Wikipedia:Carpus_and_tarsus_of_land_vertebrates" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget "The carpus (wrist) and tarsus (ankle) of land vertebrates primitively had three rows of carpal or tarsal bones. Often some of these have become lost or fused in evolution. Three proximals. In the hand humans has all three. In the foot the middle proximal appears in 5-15% of people as an os trigonum. Centrale or os centrale, on the medial side. In humans and our closest relatives the African apes (chimpanzees and gorillas) it fuses to the scaphoid where it forms the articulation with the trapezoid bone; occasionally it stays separate. In Man's foot it is the navicular. Some early land vertebrates had more than one (up to three) os centrale per hand or foot. Distals, one per finger / toe at the base of each metacarpal or metatarsal. In mammals the 4th and 5th fuse. In the horse the 1st is lost" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget "basipodium bone" . [] oboInOwl:hasDbXref "MA:0000295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003656 ; owl:annotatedTarget "carpal/tarsal bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003657 ; owl:annotatedTarget "Any joint that is part of a (free) limb." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003657 ; owl:annotatedTarget "joint of limb skeletal system" . [] oboInOwl:hasDbXref "GO:0036023" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003657 ; owl:annotatedTarget "skeletal limb joint" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget _:genid131145 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "Any muscle organ that is part of a hip [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "hip muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "hip region muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "muscle organ of hip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "muscle organ of hip region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "muscle organ of regio coxae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003658 ; owl:annotatedTarget "regio coxae muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "Any muscle organ that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "EMAPA:37333" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "digit of foot muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "digit of terminal segment of free lower limb muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "digitus pedis muscle organ" . [] oboInOwl:hasDbXref "MA:0000648" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "foot digit muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "foot digit muscle organ" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "hind limb digit muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of digit of terminal segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of digitus pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of foot digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of terminal segment of free lower limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "muscle organ of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "terminal segment of free lower limb digit muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "toe muscle organ" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003659 ; owl:annotatedTarget "foot digit muscle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000785 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "A muscle that attaches to an eyelid." . [] oboInOwl:source "ncithesaurus:Eyelid_Muscle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "The muscle in the orbit of the eye that lifts the upper eyelid[ncithesaurus:Eyelid_Muscle]." . [] oboInOwl:source "ncithesaurus:Eyelid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "UMLS:C1707990" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "blepharon muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "eyelid muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "muscle organ of blepharon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003660 ; owl:annotatedTarget "muscle organ of eyelid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "(R)-2-aminopentanedioic acid" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000785 ; owl:annotatedTarget "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget _:genid131190 . [] oboInOwl:seeAlso "https://purl.obolibrary.org/obo/uberon/tracker/324" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget _:genid131193 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget "Any muscle organ that is part of a limb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget "limb muscle organ" . [] oboInOwl:hasDbXref "OBOL:exploratory" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget "limb skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003661 ; owl:annotatedTarget "muscle organ of limb" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget _:genid131203 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "Any muscle organ that is part of a forelimb." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "FMA and MA class actually refer to muscles of entire pectoral complex" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "fore limb muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "forelimb muscle organ" . [] oboInOwl:hasDbXref "FMA:37348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "free upper limb muscle" . [] oboInOwl:hasDbXref "FMA:37348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "muscle of free upper limb" . [] oboInOwl:hasDbXref "FMA:9621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "muscle of upper limb" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "upper limb skeletal muscle" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "wing muscle" . [] oboInOwl:hasDbXref "EHDAA2:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "arm muscle system" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "musculature of arm" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003662 ; owl:annotatedTarget "musculature of the arm" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget _:genid131221 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "Any muscle organ that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "free lower limb muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "hind limb muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "hindlimb muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "inferior member muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "lower extremity muscle organ" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "lower limb skeletal muscle" . [] oboInOwl:hasDbXref "FMA:37368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle of free lower limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle of posterior limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle organ of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle organ of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle organ of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003663 ; owl:annotatedTarget "muscle organ of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "Any muscle organ that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "EMAPA:37331" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "digit of hand muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "digit of terminal segment of free upper limb muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "digitus manus muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "finger muscle organ" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "fore limb digit muscle" . [] oboInOwl:hasDbXref "MA:0000624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "hand digit muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "hand digit muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of digit of terminal segment of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of digitus manus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of hand digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "muscle organ of terminal segment of free upper limb digit" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "terminal segment of free upper limb digit muscle organ" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003664 ; owl:annotatedTarget "hand digit muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "the BTO class may possibly refer to an invertebrate structure" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "EMAPA:37759" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "muscle organ of post-vent region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "muscle organ of tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "post-vent region muscle organ" . [] oboInOwl:hasDbXref "MA:0000699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "tail muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003665 ; owl:annotatedTarget "tail muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "A molar tooth that is part of a upper jaw [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Upper_Jaw_Molar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "UMLS:C1710580" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "molar tooth of upper jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "upper jaw molar tooth" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "upper molar tooth" . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "maxillary secondary molar tooth" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "upper molar" . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "upper permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003666 ; owl:annotatedTarget "upper secondary molar tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "A molar tooth that is part of a lower jaw [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Lower_Jaw_Molar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "UMLS:C1708756" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "D-2-Aminoglutaric acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "lower jaw molar tooth" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "lower molar tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "molar tooth of lower jaw" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003667 ; owl:annotatedTarget "lower molar" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000787 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000126" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "Dentition refers to set of teeth, especially with regard to their number, kind, and arrangement, in the mouth.[AAO]" . [] oboInOwl:source "ncithesaurus:Dentition" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. (MeSH[ncithesaurus:Dentition])" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "In FMA this is an anatomical set" . [] oboInOwl:source "ncithesaurus:Dentition" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "UMLS:C0011443" . [] oboInOwl:hasDbXref "FMA:75150", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "dentes" . [] oboInOwl:hasDbXref "FMA:75150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "set of teeth" . [] oboInOwl:hasDbXref "FMA:75150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "teeth" . [] oboInOwl:hasDbXref "FMA:75150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003672 ; owl:annotatedTarget "teeth set" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338", "http://en.wikipedia.org/wiki/Memory_B_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000787 ; owl:annotatedTarget "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." . [] oboInOwl:count "1" ; oboInOwl:editor_note "cardinality not allowed with transitivity in OWL" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget _:genid131313 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "A tooth that is typically long and pointed and bearing a single cusp." . [] oboInOwl:notes "Although there are a few exceptions, the dental formula for the great majority of cricetids is 1.0.0.3" ; oboInOwl:source "Wikipedia:Cricetidae" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget obo:NCBITaxon_337687 . [] oboInOwl:source "ncithesaurus:Canine_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "UMLS:C0010482" . [] oboInOwl:hasDbXref "FMA:55636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "canine tooth" . [] oboInOwl:hasDbXref "FMA:55636", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "cuspis dentis" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "canine (tooth)" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "canine eminence" . [] oboInOwl:hasDbXref "GAID:1262", "Wikipedia:Canine_tooth" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "canine teeth" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "dens caninus" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "dentes canini" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "dogtooth (anatomy)" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "eye teeth" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "eye tooth" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "eyeteeth" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "eyetooth" . [] oboInOwl:hasDbXref "Wikipedia:Canine_tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003674 ; owl:annotatedTarget "fang" . [] oboInOwl:hasDbXref "ncithesaurus:Corona_Dentis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "The portion of the tooth covered by enamel." . [] oboInOwl:source "ncithesaurus:Corona_Dentis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "UMLS:C0226993" . [] oboInOwl:hasDbXref "FMA:55623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "anatomical crown" . [] oboInOwl:hasDbXref "ncithesaurus:Corona_Dentis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "corona dentis" . [] oboInOwl:hasDbXref "FMA:55623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "crown of tooth" . [] oboInOwl:hasDbXref "FMA:55623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003675 ; owl:annotatedTarget "tooth crown" . [] oboInOwl:hasDbXref "MP:0011165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003677 ; owl:annotatedTarget "The part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003677 ; owl:annotatedTarget "EMAPA:37975" . [] oboInOwl:hasDbXref "FMA:55624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003677 ; owl:annotatedTarget "radix corona" . [] oboInOwl:hasDbXref "FMA:55624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003677 ; owl:annotatedTarget "root of tooth" . [] oboInOwl:hasDbXref "FMA:55624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003677 ; owl:annotatedTarget "tooth root" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:Floor_of_the_Mouth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003679 ; owl:annotatedTarget "The ventral area of the mouth. In organisms with a tongue, this is the area under the ventral surface of the tongue[ncit, modified]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003679 ; owl:annotatedTarget "EMAPA:37911" . [] oboInOwl:source "ncithesaurus:Floor_of_the_Mouth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003679 ; owl:annotatedTarget "UMLS:C0026638" . [] oboInOwl:hasDbXref "FMA:86592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003679 ; owl:annotatedTarget "floor of mouth" . [] oboInOwl:hasDbXref "GAID:1283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003679 ; owl:annotatedTarget "sublingual region" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget _:genid131351 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget _:genid131353 . [] oboInOwl:source "MESH" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget _:genid131355 . [] oboInOwl:hasDbXref "MESH:A02.633.567.600", "Wikipedia:Muscles_of_mastication" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget "In humans: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)." . [] oboInOwl:source "http://php.med.unsw.edu.au/embryology" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget "originate from the somitomeres. These muscles develop late and are not complete even at birth. Tongue muscles develop before masticatory muscles and complete by birth" . [] oboInOwl:source "ncithesaurus:Muscle_of_the_Mastication" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget "UMLS:C0024890" . [] oboInOwl:hasDbXref "Wikipedia:Muscles_of_mastication" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003681 ; owl:annotatedTarget "musculi masticatorii" . [] oboInOwl:hasDbXref "MESH:A02.633.567.750", "Wikipedia:Muscles_of_soft_palate_and_fauces" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "The muscles of the palate are the glossopalatine, palatoglossus, levator palati(ni), musculus uvulae, palatopharyngeus, and tensor palati(ni)." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "see also FMA:71438 ! set of muscles of soft palate and fauces" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "EMAPA:37929" . [] oboInOwl:source "ncithesaurus:Palatal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "UMLS:C0030213" . [] oboInOwl:hasDbXref "FMA:46726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "muscle of palate" . [] oboInOwl:hasDbXref "FMA:46726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "palatal muscle" . [] oboInOwl:hasDbXref "FMA:46726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "palate muscle" . [] oboInOwl:hasDbXref "FMA:46726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "palatine muscle" . [] oboInOwl:hasDbXref "Wikipedia:Muscles_of_soft_palate_and_fauces" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003682 ; owl:annotatedTarget "musculi palati mollis et faucium" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity" . [] oboInOwl:source "ncithesaurus:Abdominal_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "UMLS:C0230168" . [] oboInOwl:hasDbXref "FMA:12266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "cavity of abdominal compartment" . [] oboInOwl:hasDbXref "FMA:12266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "cavity of compartment of abdomen" . [] oboInOwl:hasDbXref "FMA:12266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "space of abdominal compartment" . [] oboInOwl:hasDbXref "GAID:17", "Wikipedia:Abdominal_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003684 ; owl:annotatedTarget "cavitas abdominis" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget obo:UBERON_0009198 . [] oboInOwl:source "PMID:16496288" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget _:genid131393 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "D-Glutaminic acid" . [] oboInOwl:hasDbXref "FMA:71385", "ISBN:3110148986", "Wikipedia:Suture_(joint)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." . [] oboInOwl:hasDbXref "FMA:71385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget "suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget "cranium suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003685 ; owl:annotatedTarget "suture of cranium" . [] oboInOwl:hasDbXref "Wikipedia:Foramen_magnum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003687 ; owl:annotatedTarget "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002045" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003687 ; owl:annotatedTarget "Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003687 ; owl:annotatedTarget "EMAPA:37868" . [] oboInOwl:source "ncithesaurus:Foramen_Magnum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003687 ; owl:annotatedTarget "UMLS:C0016519" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget _:genid131410 . [] oboInOwl:hasDbXref "Wikipedia:Sella_turcica" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget "The sella turcica is a saddle-shaped depression in the sphenoid bone at the base of the human skull. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Sella_Turcica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget "UMLS:C0036609" . [] oboInOwl:hasDbXref "Wikipedia:Sella_turcica" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget "Turkey Chair" . [] oboInOwl:hasDbXref "Wikipedia:Sella_turcica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget "suprasellar" . [] oboInOwl:hasDbXref "Wikipedia:Sella_turcica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003689 ; owl:annotatedTarget "turkish saddle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget obo:UBERON_0008001 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget _:genid131424 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "A collection of sacral vertebrae in the sacral region that are fused and part of the bony pelvis." . [] oboInOwl:external_ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "the AAO class 'sacrum' is deliberately placed under 'sacral vertebra' rather than here" . [] oboInOwl:hasDbXref "FMA:16202", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "os sacrum [vertebrae sacrales I - V]" . [] oboInOwl:hasDbXref "FMA:16202" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "sacrum" . [] oboInOwl:hasDbXref "FMA:16202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "sacrum [sacral vertebrae I - V]" . [] oboInOwl:hasDbXref "FMA:16202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "sacrum [sacral vertebrae I-V]" . [] oboInOwl:hasDbXref "Wikipedia:Sacrum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "os sacrum" . [] oboInOwl:hasDbXref "FMA:16202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003690 ; owl:annotatedTarget "sacral bone" . [] oboInOwl:hasDbXref "Wikipedia:Epidural_space" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "The outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "in the FMA this is treated as a space of the head, but this ontology covers non-humans, where the space may continue into the tail" . [] oboInOwl:hasDbXref "Wikipedia:Epidural_space" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "cavum epidurale" . [] oboInOwl:hasDbXref "Wikipedia:Epidural_space" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "cavum extradurale" . [] oboInOwl:hasDbXref "FMA:71228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "extradural space" . [] oboInOwl:hasDbXref "Wikipedia:Epidural_space" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "spatium epidurale" . [] oboInOwl:hasDbXref "FMA:71228", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "spatium extradurale" . [] oboInOwl:hasDbXref "Wikipedia:Epidural_space" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003691 ; owl:annotatedTarget "epidural cavity" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget obo:UBERON_0011108 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget _:genid131455 . [] oboInOwl:hasDbXref "Wikipedia:Acromioclavicular_joint", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "Any joint connecting the acromonion of the scapula and clavicle." . [] oboInOwl:source "MESH:A02.835.583.032" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "The gliding joint formed by the outer extremity of the clavicle and the inner margin of the acromion process of the scapula." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000788 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:source "ncithesaurus:Acromioclavicular_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "UMLS:C0001208" . [] oboInOwl:hasDbXref "Wikipedia:Acromioclavicular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "acromioclavicular articulation" . [] oboInOwl:hasDbXref "Wikipedia:Acromioclavicular_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "articulatio acromioclavicularis" . [] oboInOwl:hasDbXref "Wikipedia:Acromioclavicular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003692 ; owl:annotatedTarget "scapuloclavicular articulation" . [] oboInOwl:hasDbXref "Wikipedia:Retroperitoneal_space" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003693 ; owl:annotatedTarget "Anatomical space in the abdominal cavity behind (retro) the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they only have peritoneum on their anterior side." . [] oboInOwl:source "ncithesaurus:Retroperitoneum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003693 ; owl:annotatedTarget "UMLS:C0035359" . [] oboInOwl:hasDbXref "FMA:15080" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003693 ; owl:annotatedTarget "retroperitoneum" . [] oboInOwl:hasDbXref "Wikipedia:Retroperitoneum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003693 ; owl:annotatedTarget "spatium retroperitoneale" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676", "PMID:20081059", "PMID:20839338", "PMID:20933013", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000788 ; owl:annotatedTarget "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." . [] oboInOwl:source "ncithesaurus:Atlanto-axial_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "UMLS:C0004168" . [] oboInOwl:hasDbXref "GAID:250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "atlanto axial joint" . [] oboInOwl:hasDbXref "GAID:250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "atlantoaxial joint" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "articulatio atlantoaxialis" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "articulatio atlantoepistrophica" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "atlantoaxial" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "lateral atlanto-axial joint" . [] oboInOwl:hasDbXref "Wikipedia:Atlanto-axial_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003694 ; owl:annotatedTarget "median atlanto-axial joint" . [] oboInOwl:hasDbXref "Wikipedia:Metacarpophalangeal_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted]." . [] oboInOwl:hasDbXref "FMA:35246" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "metacarpal joint" . [] oboInOwl:source "ncithesaurus:Metacarpophalangeal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "UMLS:C0025525" . [] oboInOwl:hasDbXref "FMA:35246" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "MP joint" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "knuckle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "knuckles" . [] oboInOwl:hasDbXref "MA:0000453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "metacarpo-phalangeal joint" . [] oboInOwl:hasDbXref "NCBITaxon:8782" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "carpometacarpophalangeal joint" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "D-Glutaminsaeure" . [] oboInOwl:hasDbXref "Wikipedia:Metacarpophalangeal_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "articulationes metacarpophalangeae" . [] oboInOwl:hasDbXref "HP:0004294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003695 ; owl:annotatedTarget "metacarpal phalangeal joint" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsophalangeal_articulations" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral." . [] oboInOwl:source "ncithesaurus:Metatarsophalangeal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "UMLS:C0025589" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "metatarsal-phalangeal joint" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsophalangeal_articulations" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "articulationes metatarsophalangeae" . [] oboInOwl:hasDbXref "FMA:35222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "metatarsal joint" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsophalangeal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "metatarsalphalangeal joint" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsophalangeal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "metatarsophalangeal" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsophalangeal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003696 ; owl:annotatedTarget "metatarsophalangeal articulation" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000789 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "ncithesaurus:Abdominal_Wall" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "EMAPA:37064" . [] oboInOwl:source "ncithesaurus:Abdominal_Wall" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "UMLS:C0836916" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_wall" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "paries abdominalis" . [] oboInOwl:hasDbXref "FMA:259054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "wall of abdomen" . [] oboInOwl:hasDbXref "FMA:10429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "wall of abdomen proper" . [] oboInOwl:hasDbXref "FMA:10429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "abdominal wall proper" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_wall" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "layers of the abdominal wall" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_wall" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003697 ; owl:annotatedTarget "paries abdominalis" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000789 ; owl:annotatedTarget "A T cell that expresses an alpha-beta T cell receptor complex." . [] oboInOwl:source "MESH" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget obo:UBERON_0008447 . [] oboInOwl:hasDbXref "Wikipedia:Subtalar_joint", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "A joint of the pes that connects the talus and the calcaneus." . [] oboInOwl:source "ncithesaurus:Subtalar_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "UMLS:C0038593" . [] oboInOwl:hasDbXref "FMA:35198", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "articulatio subtalaris" . [] oboInOwl:hasDbXref "FMA:35198", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "articulatio talocalcanea" . [] oboInOwl:hasDbXref "FMA:35198" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "subtalar joint" . [] oboInOwl:hasDbXref "Wikipedia:Subtalar_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "talocalcaneal articulation" . [] oboInOwl:hasDbXref "GAID:260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003698 ; owl:annotatedTarget "talocalcaneal joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget obo:UBERON_0002216 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget _:genid131546 . [] oboInOwl:hasDbXref "MP:0009575", "Wikipedia:Pubic_symphysis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "The firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000769" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "Medial attachment of the two halves of the pelvic girdle.[AAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "EMAPA:37940" . [] oboInOwl:source "ncithesaurus:Pubic_Symphisis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "UMLS:C0034015" . [] oboInOwl:hasDbXref "FMA:16950" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "symphysis pubis" . [] oboInOwl:hasDbXref "Wikipedia:Pubic_symphysis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "interpubic articulation" . [] oboInOwl:hasDbXref "Wikipedia:Pubic_symphysis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "symphisis pubis" . [] oboInOwl:hasDbXref "Wikipedia:Pubic_symphysis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "symphysis pubica" . [] oboInOwl:hasDbXref "Wikipedia:Pubic_symphysis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003699 ; owl:annotatedTarget "symphysis pubis" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget _:genid131567 . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "A synovial joint of the jaw that connects the mandible to the temporal bone." . [] oboInOwl:source "ncithesaurus:Jaw_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "UMLS:C0039493" . [] oboInOwl:hasDbXref "BTO:0003674", "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "TMJ" . [] oboInOwl:hasDbXref "HP:0010754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "temperomandibular joint" . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "articulatio temporomandibularis" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryT.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "dentary-squamosal joint" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryT.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "squamosal-dentary joint" . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "tempero-mandibular joint" . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "temporalmandibular joint" . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "temporomandibular" . _:genid130479 oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "temporomandibular articulation" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000790 ; owl:annotatedTarget obo:CL_0000789 . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003700 ; owl:annotatedTarget "temporomandibular joint" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget obo:UBERON_0000043 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget _:genid131587 . [] oboInOwl:hasDbXref "Wikipedia:Achilles_tendon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "The Achilles tendon is a tendon of the posterior leg. It serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "in FMA this is a ligament, and part of the muscle" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000790 ; owl:annotatedTarget "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." . [] oboInOwl:source "ncithesaurus:Achilles_Tendon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "UMLS:C0001074" . [] oboInOwl:hasDbXref "MA:0002993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "Achilles tendon" . [] oboInOwl:hasDbXref "FMA:51061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "calcaneal tendon" . [] oboInOwl:hasDbXref "Wikipedia:Achilles_tendon" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "tendo Achillis" . [] oboInOwl:hasDbXref "MA:0002993" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003701 ; owl:annotatedTarget "tendo calcaneus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget obo:UBERON_0004111 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget _:genid131598 . _:genid130497 oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MESH:A01.047.412", "MP:0003673" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget "The passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget "EMAPA:37881" . [] oboInOwl:source "ncithesaurus:Inguinal_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget "UMLS:C0021445" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "DGL" . [] oboInOwl:hasDbXref "Wikipedia:Inguinal_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003702 ; owl:annotatedTarget "canalis inguinalis" . [] oboInOwl:hasDbXref "MESH:A03.159.183.079" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003703 ; owl:annotatedTarget "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." . [] oboInOwl:source "ncithesaurus:Extrahepatic_Bile_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003703 ; owl:annotatedTarget "UMLS:C0206187" . [] oboInOwl:hasDbXref "MA:0002659" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003703 ; owl:annotatedTarget "bile duct extrahepatic part" . [] oboInOwl:hasDbXref "GAID:281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003703 ; owl:annotatedTarget "extrahepatic biliary system" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget obo:UBERON_0002394 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget _:genid131613 . [] oboInOwl:hasDbXref "MESH:A03.159.183.158" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005169" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget "Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO]" . [] oboInOwl:source "ncithesaurus:Intrahepatic_Bile_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget "UMLS:C0005401" . [] oboInOwl:hasDbXref "MA:0001630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003704 ; owl:annotatedTarget "bile duct intrahepatic part" . _:genid130517 oboInOwl:source "BTO", "FMA-abduced" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget _:genid131620 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget _:genid131622 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "Either of two pairs of folds of mucous membrane projecting into the larynx." . [] oboInOwl:source "ncithesaurus:Vocal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "UMLS:C0042930" . [] oboInOwl:hasDbXref "FMA:55457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "true vocal cord" . [] oboInOwl:hasDbXref "FMA:55457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "vocal cord" . [] oboInOwl:hasDbXref "BTO:0005084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "plica vocalis" . [] oboInOwl:hasDbXref "BTO:0005084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "vocal band" . [] oboInOwl:hasDbXref "BTO:0005084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "vocal chord" . [] oboInOwl:hasDbXref "MESH:A04.329.364.737" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003706 ; owl:annotatedTarget "vocal fold" . [] oboInOwl:source "FMA", "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget _:genid131633 . [] oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "One of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve." . [] oboInOwl:source "ncithesaurus:Sinus_of_Valsava" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "UMLS:C0503361" . [] oboInOwl:hasDbXref "MP:0010483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "Petit sinus" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "Petit's sinus" . [] oboInOwl:hasDbXref "MP:0010483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "Valsalva sinus" . [] oboInOwl:hasDbXref "MP:0010483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "aortic sinus" . _:genid130535 oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "sinus aorta" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "sinus aortae" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "sinus of Morgagni" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003707 ; owl:annotatedTarget "sinus of Otto" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget _:genid131646 . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget _:genid131648 . [] oboInOwl:hasDbXref "Wikipedia:Circle_of_Willis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle." . [] oboInOwl:source "http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "In zebrafish, the circle of vessels comprised of the basal communicating artery (BCA) and posterior communicating segments (PCS) superficially resemble but are not homologous to the human circle of Willis" . [] oboInOwl:hasDbXref "Wikipedia:Circle_of_Willis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "arterial circle" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "EMAPA:37829" . [] oboInOwl:hasDbXref "GAID:486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "cerebral arterial circle" . [] oboInOwl:hasDbXref "GAID:486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "Willis circle" . [] oboInOwl:hasDbXref "Wikipedia:Circle_of_Willis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003709 ; owl:annotatedTarget "circulus arteriosus cerebri" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000791 ; owl:annotatedTarget obo:CL_0000789 . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." . [] oboInOwl:source "ncithesaurus:Innominate_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "UMLS:C0006095" . [] oboInOwl:hasDbXref "FMA:4723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "brachiocephalic venous tree" . [] oboInOwl:hasDbXref "FMA:4723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "innominate vein" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "innomiate vein" . _:genid130555 oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "innominate trunk" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012142 . [] oboInOwl:hasDbXref "GAID:529", "Wikipedia:Brachiocephalic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "innominate vein" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "innominate veins" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "vena brachiocephalica" . [] oboInOwl:hasDbXref "Wikipedia:Brachiocephalic_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003711 ; owl:annotatedTarget "venae anonyma" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000791 ; owl:annotatedTarget "A alpha-beta T cell that has a mature phenotype." . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "The cavernous sinus (or lateral sellar compartment), within the human head, is a large collection of thin-walled veins creating a cavity bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica." . [] oboInOwl:source "MESH:A07.231.908.224.334" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "An irregularly shaped venous space in the dura mater at either side of the sphenoid bone[MESH:A07.231.908.224.334]." . [] oboInOwl:source "ncithesaurus:Cavernous_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "UMLS:C0007473" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "cavernous" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "cavernous sinus syndrome" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "cavernous sinuses" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "cavernus sinus vein" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "parasellar syndrome" . [] oboInOwl:hasDbXref "Wikipedia:Cavernous_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003712 ; owl:annotatedTarget "sinus cavernosus" . [] oboInOwl:hasDbXref "ncithesaurus:Splenic_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "EMAPA:37226" . [] oboInOwl:source "ncithesaurus:Splenic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "UMLS:C0038001" . [] oboInOwl:hasDbXref "FMA:14331", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "vena splenica" . [] oboInOwl:hasDbXref "MA:0002164", "Wikipedia:Splenic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "lienal vein" . [] oboInOwl:hasDbXref "Wikipedia:Splenic_vein" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003713 ; owl:annotatedTarget "vena lienalis" . ( ) . [] oboInOwl:hasDbXref "FMA:9642" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000325" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "FMA definition includes vasculature" . [] oboInOwl:source "ncithesaurus:Nervous_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "UMLS:C0027757" . [] oboInOwl:hasDbXref "FMA:9642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "nerve tissue" . [] oboInOwl:hasDbXref "FMA:9642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "nervous tissue" . [] oboInOwl:hasDbXref "FMA:9642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003714 ; owl:annotatedTarget "portion of neural tissue" . [] oboInOwl:hasDbXref "MP:0008318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003715 ; owl:annotatedTarget "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003715 ; owl:annotatedTarget "EMAPA:37959" . [] oboInOwl:hasDbXref "BAMS:spn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003715 ; owl:annotatedTarget "splanchnic nerves" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15966 ; owl:annotatedTarget "glutamic acid D-form" . [] oboInOwl:hasDbXref "Wikipedia:Splanchnic_nerves" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003715 ; owl:annotatedTarget "visceral nerve" . _:genid130601 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001737, obo:UBERON_0012142 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget _:genid131711 . [] oboInOwl:hasDbXref "Wikipedia:Recurrent_laryngeal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch." . [] oboInOwl:source "AAO:0010754" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "Branch of the vagus nerve that separates from the vagus well postcranially, then continues anteriorly to innervate the larynx[AAO:0010754]." . [] oboInOwl:hasDbXref "Wikipedia:Recurrent_laryngeal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "recurrent nerve" . [] oboInOwl:hasDbXref "Wikipedia:Recurrent_laryngeal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "nervus laryngeus recurrens" . [] oboInOwl:hasDbXref "VHOG:0001347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "vagus X nerve recurrent laryngeal branch" . [] oboInOwl:hasDbXref "GAID:804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "inferior laryngeal nerve" . [] oboInOwl:hasDbXref "AAO:0010754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003716 ; owl:annotatedTarget "ramus recurrens" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003721 ; owl:annotatedTarget "The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue." . [] oboInOwl:hasDbXref "MA:0001102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003721 ; owl:annotatedTarget "trigeminal V nerve lingual branch" . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "The vestibular nerve is one of the two branches of the Vestibulocochlear nerve (the cochlear nerve being the other). It goes to the semicircular canals via the vestibular ganglion. It receives positional information. Axons of the vestibular nerve synapse in the vestibular nucleus on the lateral floor and wall of the fourth ventricle in the pons and medulla. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper part of the outer end of the internal auditory meatus. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Vestibular_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "UMLS:C0042598" . [] oboInOwl:hasDbXref "FMA:53401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "vestibular root of acoustic nerve" . [] oboInOwl:hasDbXref "FMA:53401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "vestibular root of eighth cranial nerve" . [] oboInOwl:hasDbXref "MA:0001111" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "vestibulocochlear VIII nerve vestibular component" . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "nervus vestibularis" . [] oboInOwl:hasDbXref "GAID:840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "scarpa ganglion" . [] oboInOwl:hasDbXref "GAID:840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "scarpa's ganglion" . [] oboInOwl:hasDbXref "GAID:840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "scarpas ganglion" . _:genid130638 oboInOwl:hasDbXref "BAMS:vVIIIn" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003723 ; owl:annotatedTarget "vestibulocochlear nerve vestibular root" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012142 . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/musculocutaneous%20nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003724 ; owl:annotatedTarget "A large branch of the brachial plexus supplying various parts of the upper arm (as flexor muscles) and forearm (as the skin)." . [] oboInOwl:hasDbXref "FMA:37064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003724 ; owl:annotatedTarget "casserio's nerve" . [] oboInOwl:hasDbXref "Wikipedia:Musculocutaneous_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003724 ; owl:annotatedTarget "nervus musculocutaneus" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003725 ; owl:annotatedTarget "An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle." . [] oboInOwl:hasDbXref "FMA:5904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003725 ; owl:annotatedTarget "cervical nerve plexus" . [] oboInOwl:hasDbXref "FMA:5904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003725 ; owl:annotatedTarget "cervical plexus" . [] oboInOwl:hasDbXref "FMA:5904", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003725 ; owl:annotatedTarget "plexus cervicalis" . [] oboInOwl:hasDbXref "Wikipedia:Cervical_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003725 ; owl:annotatedTarget "plexus cervicalis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "MESH:A08.800.800.720.800" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003726 ; owl:annotatedTarget "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." . [] oboInOwl:hasDbXref "FMA:5860", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003726 ; owl:annotatedTarget "nervus thoracis" . [] oboInOwl:hasDbXref "FMA:5860" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003726 ; owl:annotatedTarget "thoracic spinal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_nerves" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003726 ; owl:annotatedTarget "nervi thoracici" . [] oboInOwl:hasDbXref "GAID:857" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003726 ; owl:annotatedTarget "pectoral nerve" . [] oboInOwl:hasDbXref "Wikipedia:Intercostal_nerves" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149", "PMID:19464985", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:source "ncithesaurus:Intercostal_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "UMLS:C1285089" . [] oboInOwl:hasDbXref "FMA:6028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "anterior ramus of thoracic nerve" . [] oboInOwl:hasDbXref "FMA:6028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "anterior ramus of thoracic spinal nerve" . [] oboInOwl:hasDbXref "FMA:6028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "ramus anterior, nervus thoracicus" . [] oboInOwl:hasDbXref "FMA:6028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "thoracic anterior ramus" . [] oboInOwl:hasDbXref "FMA:6028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "ventral ramus of thoracic spinal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Intercostal_nerves" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003727 ; owl:annotatedTarget "nervi intercostales" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003728 ; owl:annotatedTarget _:genid131778 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Mediastinum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003728 ; owl:annotatedTarget "The central part of the thoracic cavity enclosed by the left and right pleurae." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000792 ; owl:annotatedTarget "Treg" . [] oboInOwl:source "ncithesaurus:Mediastinum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003728 ; owl:annotatedTarget "UMLS:C0025066" . [] oboInOwl:hasDbXref "FMA:9826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003728 ; owl:annotatedTarget "mediastinal part of chest" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "A mucous membrane that lines the mouth." . [] oboInOwl:source "Wikipedia:Oral_mucosa" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]." . [] oboInOwl:source "ncithesaurus:Oral_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "UMLS:C0026639" . [] oboInOwl:hasDbXref "FMA:59660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mouth mucosa" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mouth mucous membrane" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mouth organ mucosa" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mucosa of mouth" . [] oboInOwl:hasDbXref "FMA:59660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mucous membrane of mouth" . [] oboInOwl:hasDbXref "FMA:59660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "oral part of viscerocranial mucosa" . [] oboInOwl:hasDbXref "FMA:59660", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "tunica mucosa oris" . [] oboInOwl:hasDbXref "GAID:951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "buccal mucosa" . [] oboInOwl:hasDbXref "MA:0002794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "mucosal lining of mouth" . [] oboInOwl:hasDbXref "GAID:951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "oral mucosa" . [] oboInOwl:hasDbXref "Wikipedia:Oral_mucosa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003729 ; owl:annotatedTarget "tunica mucosa oris" . [] oboInOwl:source "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003820 ; owl:annotatedTarget _:genid131810 . [] oboInOwl:hasDbXref "GO:0060513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003820 ; owl:annotatedTarget "A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." . [] oboInOwl:hasDbXref "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003820 ; owl:annotatedTarget "prostate ductal progenitor" . [] oboInOwl:hasDbXref "EMAPA:36141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003820 ; owl:annotatedTarget "prostate gland bud" . [] oboInOwl:source "FMA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget obo:UBERON_0002495 . [] oboInOwl:notes "https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget _:genid131820 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "A bone of the metapodial skeleton." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "EMAPA:37284" . [] oboInOwl:hasDbXref "MA:0000301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "metacarpal/metatarsal bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "metapodi bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "metapodial bone" . [] oboInOwl:hasDbXref "http://en.wiktionary.org/wiki/metapodial", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003821 ; owl:annotatedTarget "metapodium bone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000795 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget _:genid131832 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "The part of the forelimb between pectoral region and the elbow, corresponding to the humerus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000887" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "Segment of the hindleg corresponding to the humerus.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000343" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Arm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "UMLS:C0446516" . [] oboInOwl:hasDbXref "VSAO:0005057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "brachium" . [] oboInOwl:hasDbXref "AAO:0000199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "fore propodium" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "forelimb stylopodial element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "forelimb stylopodium" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000795 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:hasDbXref "FMA:24890", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "regio brachialis" . [] oboInOwl:hasDbXref "MA:0000035" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "upper arm" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "wing stylopod" . [] oboInOwl:hasDbXref "FMA:24890" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003822 ; owl:annotatedTarget "arm" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget _:genid131852 . [] oboInOwl:hasDbXref "PHENOSCAPE:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000348" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "FMA:24979 denotes the middle segment (zeugopod), its placement here is correct. See obo-anatomy archives for discussion" . [] oboInOwl:source "ncithesaurus:Leg" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "UMLS:C1140621" . [] oboInOwl:hasDbXref "VSAO:0005060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "crus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hind limb middle limb segment" . [] oboInOwl:hasDbXref "VHOG:0000348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hind limb zeudopodium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hind limb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hindlimb middle limb segment" . [] oboInOwl:hasDbXref "VHOG:0000348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hindlimb zeudopodium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hindlimb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hindlimb zeugopodium" . [] oboInOwl:hasDbXref "FMA:24979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "intermediate segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "lower extremity middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "lower extremity zeugopod" . [] oboInOwl:hasDbXref "MA:0000051" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "lower leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "middle limb segment of hind limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "middle limb segment of hindlimb" . [] oboInOwl:hasDbXref "VSAO:0005060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "shank" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "zeugopod of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "zeugopod of hindlimb" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "hind epipodium" . [] oboInOwl:hasDbXref "FMA:24979", "MESH:A01.378.610.500" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003823 ; owl:annotatedTarget "leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "A nerve that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "EMAPA:37265" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "nerve of thorax" . [] oboInOwl:hasDbXref "MA:0000562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "thoracic segment nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "thorax nerve" . [] oboInOwl:hasDbXref "MA:0000562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003824 ; owl:annotatedTarget "upper body nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003825 ; owl:annotatedTarget "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003825 ; owl:annotatedTarget "EMAPA:37061" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "MA:0000528" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003825 ; owl:annotatedTarget "abdominal segment nerve" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003826 ; owl:annotatedTarget "A bone that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003826 ; owl:annotatedTarget "femur" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000798 ; owl:annotatedTarget "A T cell that expresses a gamma-delta T cell receptor complex." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "A bone that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "EMAPA:37247" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "bone of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "bone organ of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "thorax bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "thorax bone organ" . [] oboInOwl:hasDbXref "MA:0000559" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003827 ; owl:annotatedTarget "upper body bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "EMAPA:37058" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "abdominal segment of trunk bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "abdominal segment of trunk bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "bone of abdominal segment of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003828 ; owl:annotatedTarget "bone organ of abdominal segment of trunk" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003829 ; owl:annotatedTarget "Any muscle tissue that is part of the urethra." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003829 ; owl:annotatedTarget "EMAPA:37787" . [] oboInOwl:hasDbXref "MA:0002649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003829 ; owl:annotatedTarget "urethral muscle layer" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003830 ; owl:annotatedTarget _:genid131934 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003830 ; owl:annotatedTarget "Any muscle organ that is part of a thorax [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003830 ; owl:annotatedTarget "muscle organ of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003830 ; owl:annotatedTarget "thorax muscle organ" . [] oboInOwl:hasDbXref "MA:0000561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003830 ; owl:annotatedTarget "upper body muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003831 ; owl:annotatedTarget "Any muscle organ that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003831 ; owl:annotatedTarget "apparatus respiratorius muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003831 ; owl:annotatedTarget "muscle organ of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003831 ; owl:annotatedTarget "muscle organ of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003831 ; owl:annotatedTarget "respiratory system muscle organ" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget _:genid131953 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "Any muscle organ that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "esophagus muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "gullet muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "muscle organ of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "muscle organ of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "muscle organ of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003832 ; owl:annotatedTarget "oesophagus muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003833 ; owl:annotatedTarget "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003833 ; owl:annotatedTarget "EMAPA:37060" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003833 ; owl:annotatedTarget "abdominal segment of trunk muscle organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003833 ; owl:annotatedTarget "muscle organ of abdominal segment of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003834 ; owl:annotatedTarget "A blood vessel that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003834 ; owl:annotatedTarget "EMAPA:37238" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003834 ; owl:annotatedTarget "blood vessel of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003834 ; owl:annotatedTarget "thorax blood vessel" . [] oboInOwl:hasDbXref "MA:0000558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003834 ; owl:annotatedTarget "upper body blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003835 ; owl:annotatedTarget "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003835 ; owl:annotatedTarget "EMAPA:37057" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003835 ; owl:annotatedTarget "abdominal segment of trunk blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003835 ; owl:annotatedTarget "blood vessel of abdominal segment of trunk" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000799 ; owl:annotatedTarget obo:CL_0000798 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003836 ; owl:annotatedTarget "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003836 ; owl:annotatedTarget "EMAPA:37063" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003836 ; owl:annotatedTarget "abdominal segment of trunk skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003836 ; owl:annotatedTarget "skin of abdominal segment of trunk" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000799 ; owl:annotatedTarget "A gamma-delta T cell that has an immature phenotype." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "A portion of connective tissue that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "EMAPA:37253" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "connective tissue of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "portion of connective tissue of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "textus connectivus of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "thorax connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "thorax portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "thorax textus connectivus" . [] oboInOwl:hasDbXref "MA:0000560" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003837 ; owl:annotatedTarget "upper body connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "EMAPA:37059" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "abdominal segment of trunk connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "abdominal segment of trunk portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "abdominal segment of trunk textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "connective tissue of abdominal segment of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "portion of connective tissue of abdominal segment of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003838 ; owl:annotatedTarget "textus connectivus of abdominal segment of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "A limb joint that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "anteriormost limb joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "anteriormost limb limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "fore limb joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "fore limb limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "forelimb joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "forelimb limb joint" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of limb of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of limb of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of limb of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of limb of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "joint of limb of upper extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "limb joint of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "limb joint of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "limb joint of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "limb joint of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "limb joint of upper extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "superior member joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "superior member limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "upper extremity joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "upper extremity limb joint" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003839 ; owl:annotatedTarget "wing joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "A limb joint that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "hind limb joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "hind limb limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "hindlimb joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "hindlimb limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "inferior member joint of limb" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000800 ; owl:annotatedTarget obo:CL_0000798 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "inferior member limb joint" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of limb of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of limb of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of limb of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of limb of lower extremity" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "joint of lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "limb joint of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "limb joint of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "limb joint of inferior member" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000800 ; owl:annotatedTarget "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "limb joint of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "lower extremity joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003840 ; owl:annotatedTarget "lower extremity limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "A limb joint that is part of an autopod [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "autopod joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "autopod limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "distal free limb segment joint of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "distal free limb segment limb joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "joint of limb of autopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "joint of limb of distal free limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "limb joint of autopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "limb joint of distal free limb segment" . [] oboInOwl:hasDbXref "MA:0002715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003841 ; owl:annotatedTarget "paw joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "An anatomical space that surrounded_by a neural tube." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001119" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "cavity of neural tube" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "lumen of neural tube" . [] oboInOwl:hasDbXref "EHDAA2:0001269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "neural tube neural lumen" . [] oboInOwl:hasDbXref "EHDAA:2889" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "neural lumen" . [] oboInOwl:hasDbXref "VHOG:0001119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003842 ; owl:annotatedTarget "neurocoel" . [] oboInOwl:notes "epithelium" ; oboInOwl:source "JB" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget _:genid132100 . [] oboInOwl:hasDbXref "ZFA:0005134", "https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "Epithelium that is part of a developing tooth or dental organ." . [] oboInOwl:source "PMID:10954731" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "In the developing molar dentition of the mouse, tooth inductive po- tential resides in the dental epithelium until embryonic day (E)12.5 (3). Thereafter, tooth inductive potential shifts to neural crest-derived dental mesenchyme, which acquires the ability to direct tooth formation in nonodontogenic tissues (3, 4)" . [] oboInOwl:source "ncithesaurus:Odontogenic_Epithelial_Remnants" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "UMLS:C1709309" . [] oboInOwl:hasDbXref "ZFA:0005134" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "dental epithelia" . [] oboInOwl:hasDbXref "ZFA:0005134" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "dental epithelium" . [] oboInOwl:hasDbXref "BTO:0001723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003843 ; owl:annotatedTarget "reduced enamel epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "An epithelium that is part of an upper eyelid [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "epithelial tissue of superior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "epithelial tissue of upper eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "epithelium of superior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "epithelium of upper eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "superior eyelid epithelial tissue" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "Beilstein:2691632" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "superior eyelid epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003844 ; owl:annotatedTarget "upper eyelid epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "An epithelium that is part of a lower eyelid [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "epithelial tissue of inferior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "epithelial tissue of lower eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "epithelium of inferior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "epithelium of lower eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "inferior eyelid epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "inferior eyelid epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003845 ; owl:annotatedTarget "lower eyelid epithelial tissue" . [] oboInOwl:source "PMID:21293377" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget _:genid132137 . [] oboInOwl:hasDbXref "MP:0009544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." . [] oboInOwl:source "ncithesaurus:Thymic_Epithelial_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "UMLS:C1711423" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "epithelial tissue of thymus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "epithelial tissue of thymus gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "epithelium of thymus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "epithelium of thymus gland" . [] oboInOwl:hasDbXref "BTO:0001836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "thymic epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "thymus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "thymus gland epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003846 ; owl:annotatedTarget "thymus gland epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003847 ; owl:annotatedTarget "An artery that supplies a thyroid gland." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010490" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003847 ; owl:annotatedTarget "Part of the external carotid which supplies blood to the thyroid gland.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010490" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003847 ; owl:annotatedTarget "relationship loss: part_of external carotid (AAO:0010218)[AAO]" . [] oboInOwl:source "ncithesaurus:Thyroid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003847 ; owl:annotatedTarget "UMLS:C1711424" . [] oboInOwl:hasDbXref "Wikipedia:Gonadal_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003848 ; owl:annotatedTarget "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003848 ; owl:annotatedTarget "gonad vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003848 ; owl:annotatedTarget "gonada vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003848 ; owl:annotatedTarget "vein of gonad" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003848 ; owl:annotatedTarget "vein of gonada" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003849 ; owl:annotatedTarget obo:UBERON_0003099 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003849 ; owl:annotatedTarget "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000796" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003849 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003849 ; owl:annotatedTarget "mesencephalic neural crest" . [] oboInOwl:hasDbXref "ZFA:0000935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003849 ; owl:annotatedTarget "neural crest midbrain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003850 ; owl:annotatedTarget "A neural crest that has_potential_to_developmentally_contribute_to a telencephalon." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000812" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003850 ; owl:annotatedTarget "Cranial neural crest that is part of the telencephalon.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000799" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003850 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003850 ; owl:annotatedTarget "neural crest telencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "A neural crest that has_potential_to_developmentally_contribute_to a diencephalon." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000798" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "diencephalic neural crest" . [] oboInOwl:hasDbXref "EHDAA2:0000603" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "future diencephalon neural crest" . [] oboInOwl:hasDbXref "ZFA:0000811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "neural crest diencephalon" . [] oboInOwl:hasDbXref "EMAPA:16518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003851 ; owl:annotatedTarget "neural crest of future diencephalon" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget obo:UBERON_0003099 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0007063" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "Cranial neural crest that is part of the hindbrain.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001210" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0007063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "neural crest hindbrain" . [] oboInOwl:hasDbXref "ZFA:0007063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "rhombencephalic neural crest" . [] oboInOwl:hasDbXref "EMAPA:35747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003852 ; owl:annotatedTarget "rhombomere neural crest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003853 ; owl:annotatedTarget "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001006" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003853 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003853 ; owl:annotatedTarget "neural crest spinal cord" . [] oboInOwl:hasDbXref "VHOG:0001006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003853 ; owl:annotatedTarget "spinal neural crest" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003854 ; owl:annotatedTarget _:genid132217 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003854 ; owl:annotatedTarget "A neural plate that develops_from a future spinal cord." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "CAS:156-39-8" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000439" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003854 ; owl:annotatedTarget "Neural plate that is part of the spinal cord. [Bgee_curator][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000439" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003854 ; owl:annotatedTarget "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003854 ; owl:annotatedTarget "neural plate of spinal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003855 ; owl:annotatedTarget "Mesenchyme that is part of a developing gonad [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003855 ; owl:annotatedTarget "gonada mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003855 ; owl:annotatedTarget "mesenchyme of gonad" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000805 ; owl:annotatedTarget obo:CL_0000893 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003855 ; owl:annotatedTarget "mesenchyme of gonada" . [] oboInOwl:notes "see comments" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget _:genid132235 . [] oboInOwl:hasDbXref "https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla." . [] oboInOwl:ontology "MP" ; oboInOwl:source "J:153554" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "Mesenchyme enclosed by dental organ.[MP]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005139" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "Mesenchyme enclosed by dental organ.[TAO]" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000805 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." . [] oboInOwl:hasDbXref "ZFA:0005139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "dental mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "dental organ mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "enamel organ mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "tooth enamel organ mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003856 ; owl:annotatedTarget "tooth mesenchyme" . ( ) . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003857 ; owl:annotatedTarget _:genid132250 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003857 ; owl:annotatedTarget "Mesenchyme that is part of a developing upper eyelid [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003857 ; owl:annotatedTarget "mesenchyme of superior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003857 ; owl:annotatedTarget "mesenchyme of upper eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003857 ; owl:annotatedTarget "superior eyelid mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003858 ; owl:annotatedTarget _:genid132260 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003858 ; owl:annotatedTarget "Mesenchyme that is part of a developing lower eyelid [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003858 ; owl:annotatedTarget "inferior eyelid mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003858 ; owl:annotatedTarget "mesenchyme of inferior eyelid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003858 ; owl:annotatedTarget "mesenchyme of lower eyelid" . _:genid131145 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102, obo:UBERON_0004475 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "Mesenchyme that is part of a developing forelimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "anteriormost limb mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "fore limb mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "mesenchyme of anteriormost limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "mesenchyme of fore limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "mesenchyme of forelimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "mesenchyme of superior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "mesenchyme of upper extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "superior member mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "upper extremity mesenchyme" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003859 ; owl:annotatedTarget "wing mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "Mesenchyme that is part of a developing hindlimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "hind limb mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "inferior member mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "lower extremity mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "mesenchyme of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "mesenchyme of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "mesenchyme of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003860 ; owl:annotatedTarget "mesenchyme of lower extremity" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_arch" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "Posterior part of a vertebra that consists of a pair of pedicles and a pair of laminae, and supports seven processes: four articular processes, two transverse processes one spinous process[WP]. ZFA: A neural arch encloses the neural canal and typically meets its partner to form a neural spine." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001066" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "A neural arch encloses the neural canal and typically meets its partner to form a neural spine. The neural arch can be a replacement ossification of the basidorsal cartilage or can form directly in membrane bone.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000725" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_2002" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "Bony arch perched on the vertebral centrum; successive arches enclose the neural canal that surrounds and protects the spinal cord dorsally.[AAO]" . [] oboInOwl:source "MP:0004599:csmith" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001066" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "relationship loss: develops_from basidorsal (TAO:0001060)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001670" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.270", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "(...) certain common components [of vertebral structure] are found in nearly all vertebrate. A representative vertebra has a vertebral arch or neural arch, which extends dorsally around the spinal cord.[well established][VHOG]" . [] oboInOwl:hasDbXref "MA:0001453" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "vertebra neural arch" . [] oboInOwl:source "ncithesaurus:Arch_of_the_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "UMLS:C0223076" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "arcus vertebra" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_arch" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "arcus vertebrae" . [] oboInOwl:hasDbXref "FMA:11946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "arcus vertebrae (vertebralis)" . [] oboInOwl:hasDbXref "ZFA:0001066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "dorsal arcocentrum" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "arcus vertebrae" . [] oboInOwl:hasDbXref "MA:0001453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003861 ; owl:annotatedTarget "vertebra dorsal arch" . _:genid131190 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004480, obo:UBERON_0010683 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "A phalanx that is part of a foot digit 4 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_4_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "UMLS:C1708086" . _:genid131193 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "digit long bone of foot digit 4" ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001134 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "foot digit 4 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "foot digit 4 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001384" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "foot digit 4 phalanx" . [] oboInOwl:hasDbXref "FMA:32901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "fourth toe phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "hind limb digit 4 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "long bone of digit of foot digit 4" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "CAS:156-39-8" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "pedal digit IV phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "phalanx of foot digit 4" . [] oboInOwl:hasDbXref "FMA:32901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "phalanx of fourth toe" . _:genid131203 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003862 ; owl:annotatedTarget "foot digit 4 phalanx" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004481 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "A phalanx that is part of a foot digit 5 [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Foot_Digit_5_Phalanx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "UMLS:C1708088" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "digit long bone of foot digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "foot digit 5 digit long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "foot digit 5 long bone of digit" . [] oboInOwl:hasDbXref "MA:0001385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "foot digit 5 phalanx" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "hind limb digit 5 phalanx" . [] oboInOwl:hasDbXref "FMA:32902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "little toe phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "long bone of digit of foot digit 5" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "pedal digit V phalanx" . [] oboInOwl:hasDbXref "FMA:32902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "phalanx of fifth digit of foot" . _:genid131221 oboInOwl:hasDbXref "FMA:32902" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "phalanx of fifth toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004482 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "phalanx of foot digit 5" . [] oboInOwl:hasDbXref "FMA:32902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "phalanx of little toe" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003863 ; owl:annotatedTarget "foot digit 5 phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "A middle phalanx that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "EMAPA:37306" . [] oboInOwl:source "ncithesaurus:Middle_Phalanx_of_the_Hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "UMLS:C0223828" . [] oboInOwl:hasDbXref "MA:0001394" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "hand middle phalanx" . [] oboInOwl:hasDbXref "FMA:75817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "middle phalanx of finger" . [] oboInOwl:hasDbXref "MA:0001394" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "middle phalanx of hand" . [] oboInOwl:hasDbXref "FMA:75817", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003864 ; owl:annotatedTarget "phalanx media manus" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000806 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "A distal phalanx that is part of a finger [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Distal_Phalanx_of_Hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "UMLS:C1269782" . [] oboInOwl:hasDbXref "FMA:75818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "distal phalanx of finger" . [] oboInOwl:hasDbXref "MA:0001388" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "hand distal phalanx" . [] oboInOwl:hasDbXref "FMA:75818", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "phalanx distalis manus" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "terminal phalanx of hand" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=67679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003865 ; owl:annotatedTarget "ungual phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003866 ; owl:annotatedTarget "A middle phalanx that is part of a toe [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003866 ; owl:annotatedTarget "EMAPA:37311" . [] oboInOwl:hasDbXref "MA:0001386" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003866 ; owl:annotatedTarget "foot middle phalanx" . [] oboInOwl:hasDbXref "FMA:75829" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003866 ; owl:annotatedTarget "middle phalanx of toe" . [] oboInOwl:hasDbXref "FMA:75829", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003866 ; owl:annotatedTarget "phalanx media pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "A distal phalanx that is part of a pedal digit [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "EMAPA:37310" . [] oboInOwl:source "ncithesaurus:Distal_Phalanx_of_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "UMLS:C0224026" . [] oboInOwl:hasDbXref "FMA:75830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "distal phalanx of toe" . [] oboInOwl:hasDbXref "MA:0001380" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "foot distal phalanx" . [] oboInOwl:hasDbXref "FMA:75830", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "phalanx distalis pedis" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "terminal phalanx of foot" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "terminal phalanx of hindlimb" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=67679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "ungual phalanx of foot" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=67679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003867 ; owl:annotatedTarget "ungual phalanx of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "EMAPA:37312" . [] oboInOwl:source "ncithesaurus:Proximal_Phalanx_of_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "UMLS:C0224020" . [] oboInOwl:hasDbXref "MA:0001387" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "foot proximal phalanx" . [] oboInOwl:hasDbXref "FMA:75828", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "phalanx proximalis pedis" . [] oboInOwl:hasDbXref "FMA:75828" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003868 ; owl:annotatedTarget "proximal phalanx of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003869 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a ganglion." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "CAS:156-39-8" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003885 ; owl:annotatedTarget _:genid132426 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003885 ; owl:annotatedTarget _:genid132428 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003885 ; owl:annotatedTarget "A mesentery that is part of a uterus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:19816", "MA:0002931", "http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003885 ; owl:annotatedTarget "mesentery of uterus" . _:genid131313 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000109, obo:UBERON_0006844 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003886 ; owl:annotatedTarget "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003887 ; owl:annotatedTarget _:genid132442 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0012187" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003887 ; owl:annotatedTarget "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000316" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.166", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003887 ; owl:annotatedTarget "(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Intraembryonic_Coelom" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003887 ; owl:annotatedTarget "UMLS:C1512940" . [] oboInOwl:hasDbXref "Wikipedia:Intraembryonic_coelom" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003887 ; owl:annotatedTarget "somatic coelom" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget _:genid132455 . [] oboInOwl:hasDbXref "MGI:smb", "MP:0003574", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "Initial section of the oviduct through which the ova pass from the ovary to the uterus." . [] oboInOwl:source "Wikipedia:Talk:Fallopian_tube#Homology" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "Homologous to appendix testis" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "salpinges" . [] oboInOwl:source "ncithesaurus:Fallopian_Tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "UMLS:C0015560" . [] oboInOwl:hasDbXref "https://sourceforge.net/p/geneontology/ontology-requests/8397/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "mammalian oviduct" . [] oboInOwl:hasDbXref "EHDAA2:0000504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "female paramesonephric duct" . [] oboInOwl:hasDbXref "EMAPA:35660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "paramesonephric duct of female" . [] oboInOwl:hasDbXref "Wikipedia:Fallopian_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003889 ; owl:annotatedTarget "tuba uterina" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget _:genid132469 . [] oboInOwl:hasDbXref "GO:0061205", "Wikipedia:Paramesonephric_duct", "http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001199" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/paramesonephric+duct" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "Either of the paired embryonic ducts developing into the uterine tubes, uterus, and vagina in the female and becoming largely obliterated in the male. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010141" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:RED" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "Transient developmental organ which gives rise to oviducts in female (documented to persist in some male frogs).[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001199" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.559", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "In females, the archinephric (mesonephric) ducts tend to function only within the urinary systems. The muellerian duct arises embryologically next to the archinephric (wolffian) duct. In males, the muellerian duct regresses if it appears at all, but in females, the muellerian ducts become the oviducts of the reproductive system.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Mullerian_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "UMLS:C0026732" . [] oboInOwl:hasDbXref "EMAPA:27665" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "paramesonephric duct" . [] oboInOwl:hasDbXref "EHDAA2:0004048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003890 ; owl:annotatedTarget "early paramesonephric duct" . _:genid131351 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003891 ; owl:annotatedTarget "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000375 . [] oboInOwl:source "ncithesaurus:Stroma_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003891 ; owl:annotatedTarget "UMLS:C0927195" . _:genid131353 a owl:Restriction ; owl:onProperty obo:RO_0002007, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000061, obo:UBERON_0004362 . [] oboInOwl:hasDbXref "Wikipedia:Capsule_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003893 ; owl:annotatedTarget "A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP]." . _:genid131355 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002107 ] ) ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001134 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget obo:UBERON_0000485 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget _:genid132489 . [] oboInOwl:notes "ventral foregut endoderm" ; oboInOwl:source "Zaret 1996" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget _:genid132491 . [] oboInOwl:hasDbXref "ISBN:3211492755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." . [] oboInOwl:source "ncithesaurus:Hepatic_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "UMLS:C0734013" . [] oboInOwl:source "ncithesaurus:Primordium_of_the_Liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "UMLS:C1514451" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "embryological hepatic plate" . [] oboInOwl:hasDbXref "ncithesaurus:Primordium_of_the_Liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "primordium of the liver" . [] oboInOwl:hasDbXref "EHDAA2:0000744" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "hepatic plate" . [] oboInOwl:hasDbXref "XAO:0003266", "ZFA:0000124" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "liver bud" . [] oboInOwl:hasDbXref "EFO:0002577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003894 ; owl:annotatedTarget "liver endoderm" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003895 ; owl:annotatedTarget "Portion of myotome that is ventral to the horizontal septum." . [] oboInOwl:hasDbXref "ZFA:0001085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003895 ; owl:annotatedTarget "hypaxial myotome region" . [] oboInOwl:hasDbXref "XAO:0003228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003895 ; owl:annotatedTarget "body wall muscle" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000807 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." . [] oboInOwl:hasDbXref "HP:0003327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003897 ; owl:annotatedTarget "One of the skeletal muscles of the head and neck, spine, and ribs." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget _:genid132518 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "A portion of skeletal muscle tissue in the trunk." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "skeletal muscle of torso" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "skeletal muscle tissue of torso" . _:genid131393 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "skeletal muscle tissue of trunk" ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0002363 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "torso skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "torso skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "trunk skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003898 ; owl:annotatedTarget "trunk skeletal muscle tissue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "PMID:11073718" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003900 ; owl:annotatedTarget "Portion of myotome that is dorsal to the horizontal septum." . [] oboInOwl:hasDbXref "ZFA:0001084" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003900 ; owl:annotatedTarget "epaxial myotome regions" . [] oboInOwl:hasDbXref "ISBN:0073040584", "ZFA:0000671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003901 ; owl:annotatedTarget "A logitudinal sheet of continuous connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses; each is destined to become, respectively, the epaxial and hyopaxial musculature." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000671" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003901 ; owl:annotatedTarget "A connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses. Kimmel et al, 1995.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000671" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0003901 ; owl:annotatedTarget "relationship loss: subclass myoseptum (TAO:0001089)[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003901 ; owl:annotatedTarget "horizontal myoseptum" . _:genid131410 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001781 [ a owl:Restriction ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0005425 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009639 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget _:genid132548 . [] oboInOwl:hasDbXref "GO:0003407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "The part of the retina that contains neurons and photoreceptor cells[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000535" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Neural_Retina" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "UMLS:C1518263" . [] oboInOwl:hasDbXref "FMA:58628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "neural layer of retina" . [] oboInOwl:hasDbXref "XAO:0003216", "ZFA:0000046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "neural retina" . [] oboInOwl:hasDbXref "ZFA:0000046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "neuroretina" . _:genid131424 oboInOwl:hasDbXref "FMA:58628" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "stratum nervosum (retina)" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001270 . [] oboInOwl:hasDbXref "FMA:58628", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "stratum nervosum retinae" . [] oboInOwl:hasDbXref "MA:000027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003902 ; owl:annotatedTarget "neural retinal epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003907 ; owl:annotatedTarget "An atrioventricular canal that is in the left side of a atrioventricular region." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003907 ; owl:annotatedTarget "EHDAA2 represents lumen" . [] oboInOwl:hasDbXref "EHDAA2:0000935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003907 ; owl:annotatedTarget "left atrio-ventricular canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003908 ; owl:annotatedTarget "An atrioventricular canal that is in the right side of a atrioventricular region." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003908 ; owl:annotatedTarget "EHDAA2 represents lumen" . [] oboInOwl:hasDbXref "EHDAA2:0001719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003908 ; owl:annotatedTarget "right atrio-ventricular canal" . [] oboInOwl:source "Wikipedia-inconsistent" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget obo:UBERON_0001982 . [] oboInOwl:source "Wikipedia", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget obo:UBERON_2005260 . [] oboInOwl:hasDbXref "Wikipedia:Sinusoid_(blood_vessel)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005261" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget "Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget "some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined)." . [] oboInOwl:hasDbXref "ZFA:0005261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget "sinusoidal blood vessel endothelium" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=13986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003909 ; owl:annotatedTarget "sinusoidal capillary" . [] oboInOwl:hasDbXref "Wikipedia:Red_pulp#Sinusoids" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003910 ; owl:annotatedTarget "Wide vessels in the spleen that drain into trabecular veins[WP]." . _:genid131455 oboInOwl:source "http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0003910 ; owl:annotatedTarget obo:NCBITaxon_9681 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001467 . [] oboInOwl:source "http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0003910 ; owl:annotatedTarget obo:NCBITaxon_9822 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003910 ; owl:annotatedTarget "sinusoidal blood vessel of spleen" . [] oboInOwl:hasDbXref "FMA:63199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003910 ; owl:annotatedTarget "sinusoid of red pulp of spleen" . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Choroid_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue." . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "UMLS:C1516506" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "choroid plexus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "epithelial tissue of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "epithelial tissue of choroid plexus" . [] oboInOwl:hasDbXref "FMA:242811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003911 ; owl:annotatedTarget "epithelium of choroid plexus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003913 ; owl:annotatedTarget "Hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003913 ; owl:annotatedTarget "tooth-like organ" . [] oboInOwl:hasDbXref "GO:0060562", "PMID:12526790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003914 ; owl:annotatedTarget "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003915 ; owl:annotatedTarget "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0000444", "GO:0060613", "http://medical-dictionary.thefreedictionary.com/fat+pad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003916 ; owl:annotatedTarget "A mass of closely packed fat cells (adipose tissue) surrounded by fibrous tissue septa[TMD]." . [] oboInOwl:ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003916 ; owl:annotatedTarget "An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue[BTO]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003916 ; owl:annotatedTarget "FMA says isa fascia organ. Note that XAO and AAO have structures called fat pad/body, but these are gonad-associated, so we place them with the gonad-specific subclass" . [] oboInOwl:hasDbXref "FMA:58616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003916 ; owl:annotatedTarget "fat body" . [] oboInOwl:hasDbXref "GO:0072074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003918 ; owl:annotatedTarget "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/venous+blood+vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003920 ; owl:annotatedTarget "A blood vessel that carries blood from the capillaries toward the heart." . [] oboInOwl:hasDbXref "FMA:86188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003920 ; owl:annotatedTarget "segment of venous tree organ" . [] oboInOwl:hasDbXref "FMA:86188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003920 ; owl:annotatedTarget "venous tree organ segment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "PMID:9106023" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget _:genid132636 . [] oboInOwl:hasDbXref "Wikipedia:Pancreas#Embryological_development" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget "Embryonic structure that develops into pancreatic bud." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget "in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds" . [] oboInOwl:hasDbXref "ZFA:0000254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget "pancreatic anlage" . [] oboInOwl:hasDbXref "EFO:0002579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget "pancreatic endoderm" . [] oboInOwl:hasDbXref "FMA:79792" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003921 ; owl:annotatedTarget "primordial pancreas" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget _:genid132644 . [] oboInOwl:source "Wikipedia:Pancreas#Embryological_development" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget _:genid132646 . [] oboInOwl:exception "zebrafish" ; oboInOwl:source "Wikipedia:Pancreatic_bud" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget _:genid132649 . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget _:genid132651 . [] oboInOwl:hasDbXref "PMID:16417468", "Wikipedia:Pancreatic_bud" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." . [] oboInOwl:source "ncithesaurus:Pancreatic_Bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget "UMLS:C1283285" . [] oboInOwl:hasDbXref "ZFA:0001390" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget "pancreatic bud" . [] oboInOwl:hasDbXref "TAO:0001390" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget "pancreatic buds" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000808 ; owl:annotatedTarget "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." . [] oboInOwl:hasDbXref "EMAPA:35645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003922 ; owl:annotatedTarget "pancreas epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget _:genid132658 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget _:genid132660 . [] oboInOwl:hasDbXref "Wikipedia:Pancreatic_bud" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget "Pancreatic bud that gives rise to the accessory pancreatic duct." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011031" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget "The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001428" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget "pancreas dorsal primordium duct bud" . [] oboInOwl:hasDbXref "XAO:0000467" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003923 ; owl:annotatedTarget "primary pancreatic bud" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003924 ; owl:annotatedTarget _:genid132667 . [] oboInOwl:source "PMID:16417468", "WP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003924 ; owl:annotatedTarget _:genid132669 . [] oboInOwl:hasDbXref "Wikipedia:Pancreatic_bud" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003924 ; owl:annotatedTarget "Pancreatic bud that gives rise to the major pancreatic duct." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001429" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0003924 ; owl:annotatedTarget "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003924 ; owl:annotatedTarget "pancreas ventral primordium duct bud" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003928 ; owl:annotatedTarget "A duct that is part of a digestive system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003928 ; owl:annotatedTarget "duct of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003928 ; owl:annotatedTarget "duct of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003928 ; owl:annotatedTarget "gastrointestinal system duct" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "An epithelium that lines the lumen of the digestive tract." . _:genid131546 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005123" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "Epithelium lining the lumen of the gut.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002355 . [] oboInOwl:source "ncithesaurus:Gut_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "UMLS:C0836205" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "digestive tract epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "epithelial tissue of digestive tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "epithelial tissue of gut" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "epithelium of digestive tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "epithelium of gut" . [] oboInOwl:hasDbXref "NCBITaxon:6073", "https://orcid.org/0000-0003-3308-6245" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "gastrodermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "gut epithelial tissue" . [] oboInOwl:hasDbXref "EHDAA2:0004567", "MA:0003201", "ZFA:0005123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "gut epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003929 ; owl:annotatedTarget "alimentary tract epithelium" . [] oboInOwl:hasDbXref "ZFA:0001616" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003930 ; owl:annotatedTarget "Endocardium that is part of the atrioventricular canal[ZFA,vetted]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003930 ; owl:annotatedTarget "AV canal endocardium" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003930 ; owl:annotatedTarget "AVC endocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003930 ; owl:annotatedTarget "endocardium of AV canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003930 ; owl:annotatedTarget "endocardium of atrioventricular canal" . (obo:UBERON_0002316 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003931 ; owl:annotatedTarget "White matter that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:hasDbXref "ZFA:0000338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003931 ; owl:annotatedTarget "diencephalic tract/commissure" . [] oboInOwl:hasDbXref "TAO:0000338" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003931 ; owl:annotatedTarget "diencephalic tracts and commissures" . [] oboInOwl:hasDbXref "BIRNLEX:1678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003931 ; owl:annotatedTarget "predominantly white regional part of diencephalon" . [] oboInOwl:hasDbXref "FMA:83931" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003931 ; owl:annotatedTarget "white matter of diencephalon" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003932 ; owl:annotatedTarget "A cartilage element of chondrocranium. Example: neurocranial trabecula." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003932 ; owl:annotatedTarget "cartilage of chondrocranium" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003932 ; owl:annotatedTarget "cartilaginous element of chondrocranium" . [] oboInOwl:hasDbXref "ZFA:0001461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003932 ; owl:annotatedTarget "chondrocranium cartilage" . [] oboInOwl:hasDbXref "ZFA:0001461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003932 ; owl:annotatedTarget "neurocranium cartilage" . ( ) . [] oboInOwl:hasDbXref "ZFA:0001458", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003933 ; owl:annotatedTarget "A cartilage element that is part of the cranial skeleton." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001458" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003933 ; owl:annotatedTarget "Cartilage which is part of the cranium.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003933 ; owl:annotatedTarget "cartilage of cranium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003933 ; owl:annotatedTarget "cranium cartilage" . [] oboInOwl:hasDbXref "ZFA:0001458" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003933 ; owl:annotatedTarget "cranial cartilages" . [] oboInOwl:hasDbXref "MP:0000653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." . _:genid131598 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "genitalia gland" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003697 . [] oboInOwl:hasDbXref "MP:0000653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "gland of genitalia" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "Reaxys:2691632" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "gland of reproductive system" . [] oboInOwl:hasDbXref "MA:0001751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "reproductive gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "reproductive system gland" . [] oboInOwl:hasDbXref "MP:0000653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003937 ; owl:annotatedTarget "sex gland" . [] oboInOwl:hasDbXref "NLXANAT:090818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003942 ; owl:annotatedTarget "The sensory system for the sense of touch and pain." . [] oboInOwl:source "MP:0000959" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003942 ; owl:annotatedTarget "The neural tissue involved in the transmission of sensory signals" . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0003942 ; owl:annotatedTarget "MP defines this in a may more appropriate to somatosensory cortex" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003942 ; owl:annotatedTarget "EMAPA:37954" . [] oboInOwl:hasDbXref "MP:0001716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003946 ; owl:annotatedTarget "The placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood." . _:genid131613 oboInOwl:hasDbXref "GO:0060713" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003946 ; owl:annotatedTarget "labyrinthine layer" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002107 . [] oboInOwl:hasDbXref "GO:0060713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003946 ; owl:annotatedTarget "labyrinthine layer of placenta" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000809 ; owl:annotatedTarget obo:CL_0000790 . _:genid131620 oboInOwl:hasDbXref "MP:0002200" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003947 ; owl:annotatedTarget "The brain ventricles or their associated choroid plexuses." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002486 . _:genid131622 a owl:Restriction ; owl:onProperty obo:BSPO_0000126, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001802, obo:UBERON_0002486 . [] oboInOwl:hasDbXref "MP:0002864", "Wikipedia:Fundus_(eye)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003951 ; owl:annotatedTarget "The posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003951 ; owl:annotatedTarget "EMAPA:37916" . [] oboInOwl:source "ncithesaurus:Fundus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003951 ; owl:annotatedTarget "UMLS:C0740422" . [] oboInOwl:hasDbXref "HP:0001098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003951 ; owl:annotatedTarget "fundus" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000809 ; owl:annotatedTarget "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." . _:genid131633 oboInOwl:source "lexical" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0003952 ; owl:annotatedTarget obo:UBERON_0003953 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010172 . [] oboInOwl:hasDbXref "MP:0003093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003952 ; owl:annotatedTarget "The anterior segment of the lamellated connective tissue layer of the cornea." . [] oboInOwl:hasDbXref "MP:0003093" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003952 ; owl:annotatedTarget "anterior stroma" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003952 ; owl:annotatedTarget "EMAPA:37414" . [] oboInOwl:hasDbXref "MP:0003093" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003952 ; owl:annotatedTarget "cornea anterior stroma" . [] oboInOwl:hasDbXref "MP:0003094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003953 ; owl:annotatedTarget "The posterior segment of the lamellated connective tissue layer of the cornea." . [] oboInOwl:hasDbXref "MP:0003094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003953 ; owl:annotatedTarget "posterior stroma" . _:genid131646 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003953 ; owl:annotatedTarget "EMAPA:37415" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0007142 . [] oboInOwl:hasDbXref "MP:0003094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003953 ; owl:annotatedTarget "cornea posterior stroma" . _:genid131648 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000210 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001695 ] ) ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0007143 . [] oboInOwl:hasDbXref "MP:0003844", "Wikipedia:Squamosal_suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "The articulation of the squamous portion of the temporal bones with the parietal bones[MP]. The squamosal suture arches backward from the pterion and connects the temporal squama with the lower border of the parietal: this suture is continuous behind with the short, nearly horizontal parietomastoid suture, which unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP]." . [] oboInOwl:hasDbXref "MP:0003844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "squamo-parietal suture" . [] oboInOwl:hasDbXref "Wikipedia:Squamosal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "sutura squamosa cranii" . [] oboInOwl:hasDbXref "Wikipedia:Squamosal_suture" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "squamosal suture" . [] oboInOwl:hasDbXref "Wikipedia:Squamosal_suture" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "squamous suture" . [] oboInOwl:hasDbXref "FMA:52946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003954 ; owl:annotatedTarget "squamous suture of skull" . [] oboInOwl:hasDbXref "MP:0003932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "The part of a molar that is covered by enamel." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "EMAPA:37910" . [] oboInOwl:hasDbXref "FMA:85301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "crown of molar tooth" . [] oboInOwl:hasDbXref "FMA:85301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "molar tooth crown" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "molar tooth tooth crown" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003955 ; owl:annotatedTarget "tooth crown of molar tooth" . [] oboInOwl:hasDbXref "MP:0005198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003956 ; owl:annotatedTarget "The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003956 ; owl:annotatedTarget "EMAPA:37427" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003959 ; owl:annotatedTarget _:genid132818 . [] oboInOwl:hasDbXref "MP:0006416", "Wikipedia:Rete_testis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003959 ; owl:annotatedTarget "An anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia[WP]." . [] oboInOwl:source "ncithesaurus:Rete_Testis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003959 ; owl:annotatedTarget "UMLS:C0035278" . [] oboInOwl:hasDbXref "FMA:19834" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003959 ; owl:annotatedTarget "Haller's rete" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget _:genid132827 . [] oboInOwl:source "MP-implied-by-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget _:genid132829 . [] oboInOwl:hasDbXref "MP:0008023", "Wikipedia:Temporal_styloid_process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "Slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments." . [] oboInOwl:hasDbXref "FMA:52877", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "processus styloideus" . [] oboInOwl:hasDbXref "Wikipedia:Temporal_styloid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "processus styloideus ossis temporalis" . [] oboInOwl:hasDbXref "FMA:52877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "styloid process" . [] oboInOwl:hasDbXref "FMA:52877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "styloid process of petrous part of temporal bone" . [] oboInOwl:hasDbXref "Wikipedia:Temporal_styloid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "temporal styloid process" . [] oboInOwl:hasDbXref "Wikipedia:Temporal_styloid_process" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003960 ; owl:annotatedTarget "processus styloideus ossis temporalis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "3-(4-hydroxyphenyl)-2-oxopropanoic acid" . [] oboInOwl:hasDbXref "MP:0008418" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003967 ; owl:annotatedTarget "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003967 ; owl:annotatedTarget "EMAPA:37841" . [] oboInOwl:hasDbXref "MP:0008418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003967 ; owl:annotatedTarget "cutaneous elastic fiber" . [] oboInOwl:hasDbXref "MP:0008418" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003967 ; owl:annotatedTarget "dermal elastic fiber" . [] oboInOwl:hasDbXref "MP:0008463", "https://github.com/obophenotype/uberon/issues/4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003968 ; owl:annotatedTarget "The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003968 ; owl:annotatedTarget "EMAPA:37938" . [] oboInOwl:hasDbXref "MP:0008803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003970 ; owl:annotatedTarget "Blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate." . _:genid131711 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003970 ; owl:annotatedTarget "placental vasculature" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003117 . [] oboInOwl:hasDbXref "MP:0009209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003975 ; owl:annotatedTarget "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." . [] oboInOwl:hasDbXref "FMA:45654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003975 ; owl:annotatedTarget "female internal genitalia" . [] oboInOwl:hasDbXref "BTO:0003099" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003975 ; owl:annotatedTarget "internal female genital organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003975 ; owl:annotatedTarget "internal genitalia of female reproductive system" . [] oboInOwl:hasDbXref "BTO:0003099" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003975 ; owl:annotatedTarget "organa genitalia feminina interna" . [] oboInOwl:hasDbXref "FMA:67611" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003978 ; owl:annotatedTarget "anatomical valve" . [] oboInOwl:hasDbXref "MP:0009267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "One of a set of deep furrows which divide the lobules of the cerebellum. Examples: postcentral, primary and secondary furrows." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "EMAPA:37818" . [] oboInOwl:hasDbXref "FMA:77789", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "fissurae cerebelli" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000810 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "BAMS:CBf" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "cerebellar fissures" . [] oboInOwl:hasDbXref "FMA:77789" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "cerebellar fissures set" . [] oboInOwl:hasDbXref "HBA:9406" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "cerebellar sulci" . [] oboInOwl:hasDbXref "FMA:77789" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003980 ; owl:annotatedTarget "set of cerebellar fissures" . [] oboInOwl:hasDbXref "MP:0009464", "Wikipedia:Conus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003983 ; owl:annotatedTarget "A conical pouch formed from the upper and left angle of the right ventricle in the chordate heart, from which the pulmonary artery arises[WP]. the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminates in the pulmonary trunk[MP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010250" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003983 ; owl:annotatedTarget "Receives blood from the left atrium and becomes the median truncus arteriosus.[AAO]" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000013 ; owl:annotatedSource obo:UBERON_0003983 ; owl:annotatedTarget "we use the term CA for the anterior chamber if it is composed of cardiac muscle, contractile, and contains conal valves internally" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget obo:UBERON_0013515 . [] oboInOwl:hasDbXref "MP:0009466", "Wikipedia:Infundibulum_of_uterine_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "The funnel-like expansion of the abdominal extremity of the uterine tube[MP]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000810 ; owl:annotatedTarget "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." . [] oboInOwl:source "Wikipedia:Infundibulum_of_uterine_tube" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct." . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "infundibulum" . [] oboInOwl:hasDbXref "FMA:18307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "infundibulum of oviduct" . [] oboInOwl:hasDbXref "FMA:18307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "infundibulum of uterine tube" . [] oboInOwl:hasDbXref "FMA:18307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "infundibulum of fallopian tube" . [] oboInOwl:hasDbXref "Wikipedia:Infundibulum_of_uterine_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003984 ; owl:annotatedTarget "infundibulum tubae uterinae" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "EMAPA:37974" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymic cortico-medullary boundary" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymic corticomedullary boundary" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymic corticomedullary junction" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymic corticomedullary zone" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymus CMZ" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymus cortico-medullary boundary" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymus corticomedullary junction" . [] oboInOwl:hasDbXref "MP:0009543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0003988 ; owl:annotatedTarget "thymus corticomedullary zone" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget obo:UBERON_0010273 . [] oboInOwl:hasDbXref "MP:0009917", "Wikipedia:Body_of_hyoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "The main curve of the hyoid bone, from which the horns extend." . [] oboInOwl:hasDbXref "MA:0002958" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "base of hyoid bone" . [] oboInOwl:hasDbXref "MA:0002958" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "basihyal bone" . [] oboInOwl:hasDbXref "MA:0002958" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "basihyoid bone" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "body of hyoid" . [] oboInOwl:hasDbXref "MA:0002958" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "body of hyoid bone" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_hyoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "corpus ossis hyoidei" . _:genid131778 oboInOwl:hasDbXref "MA:0002958" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0003999 ; owl:annotatedTarget "hyoid bone base" ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0035431 . [] oboInOwl:hasDbXref "MP:0009935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004000 ; owl:annotatedTarget "A sac-like structure comprising a sebaceous gland." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004000 ; owl:annotatedTarget "EMAPA:37972" . [] oboInOwl:hasDbXref "MP:0009946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004001 ; owl:annotatedTarget "." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004001 ; owl:annotatedTarget "EMAPA:37917" . [] oboInOwl:hasDbXref "NLXANAT:20090402" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004001 ; owl:annotatedTarget "cytoarchitectural part of olfactory bulb" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004008 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004008 ; owl:annotatedTarget _:genid132940 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004008 ; owl:annotatedTarget _:genid132942 . [] oboInOwl:hasDbXref "MP:0000856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004008 ; owl:annotatedTarget "The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium." . [] oboInOwl:hasDbXref "EHDAA2:0004401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004008 ; owl:annotatedTarget "cerebellum roof plate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "4-hydroxyphenylpyruvic acid" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget _:genid132946 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget _:genid132948 . [] oboInOwl:hasDbXref "MP:0003520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget "One of the folds of skin which form the inner lips on both sides of the vaginal opening." . [] oboInOwl:source "ncithesaurus:Labium_Minus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget "UMLS:C0227766" . [] oboInOwl:hasDbXref "MA:0002845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget "labium minorum" . [] oboInOwl:hasDbXref "FMA:20374" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget "labium minus" . [] oboInOwl:hasDbXref "Wikipedia:Labia_minora", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004014 ; owl:annotatedTarget "labium minus pudendi" . ( ) . [] oboInOwl:hasDbXref "MP:0003890" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004015 ; owl:annotatedTarget "The connection between the embryo proper and extraembryonic tissues." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget obo:UBERON_0017650 . [] oboInOwl:source "AEO-text" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget _:genid132963 . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget _:genid132965 . [] oboInOwl:hasDbXref "AEO:0001017", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." . [] oboInOwl:source "ncithesaurus:Dermatome" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget "UMLS:C0180383" . [] oboInOwl:hasDbXref "Wikipedia:Cutis_plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget "cutis plate" . _:genid131820 oboInOwl:hasDbXref "Wikipedia:Cutis_plate" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget "dermatomal mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010546 . [] oboInOwl:hasDbXref "Wikipedia:Dermatomal_mesenchyme" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004016 ; owl:annotatedTarget "mesenchyma dermatomiale" . [] oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004022 ; owl:annotatedTarget obo:UBERON_0034706 . [] oboInOwl:hasDbXref "MP:0004261", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004022 ; owl:annotatedTarget "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004022 ; owl:annotatedTarget "germinal neuroepithelial layer" . [] oboInOwl:hasDbXref "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004022 ; owl:annotatedTarget "germinal neuroepithelium" . [] oboInOwl:hasDbXref "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004022 ; owl:annotatedTarget "original neural tube" . _:genid131832 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001460, obo:UBERON_0004040 . [] oboInOwl:hasDbXref "MP:0008440", "Wikipedia:Subplate", "https://github.com/obophenotype/mouse-anatomy-ontology/issues/1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004035 ; owl:annotatedTarget "The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0004035 ; owl:annotatedTarget "The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects" . [] oboInOwl:hasDbXref "BRAINSPAN:BRAINSPAN" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004035 ; owl:annotatedTarget "SP" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000811 ; owl:annotatedTarget obo:CL_0000790 . [] oboInOwl:hasDbXref "EMAPA:32833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004035 ; owl:annotatedTarget "cerebral cortex subplate" . [] oboInOwl:hasDbXref "DHBA:10522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004035 ; owl:annotatedTarget "subplate zone" . [] oboInOwl:hasDbXref "MP:0008457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004040 ; owl:annotatedTarget "The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone." . [] oboInOwl:hasDbXref "BRAINSPAN:BRAINSPAN" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004040 ; owl:annotatedTarget "IZ" . [] oboInOwl:hasDbXref "EMAPA:17545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004040 ; owl:annotatedTarget "cerebral cortex mantle layer" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000811 ; owl:annotatedTarget "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." . [] oboInOwl:hasDbXref "MP:0008471" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004041 ; owl:annotatedTarget "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004041 ; owl:annotatedTarget "FMA:15843 is classified as primary follicle so it belongs here" . _:genid131852 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004041 ; owl:annotatedTarget "EMAPA:37960" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000978 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004041 ; owl:annotatedTarget "primary spleen B cell follicle" . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004042 ; owl:annotatedTarget _:genid133008 . [] oboInOwl:hasDbXref "MP:0008472" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004042 ; owl:annotatedTarget "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004042 ; owl:annotatedTarget "EMAPA:37961" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004042 ; owl:annotatedTarget "secondary spleen B cell follicle" . [] oboInOwl:hasDbXref "MP:0008472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004042 ; owl:annotatedTarget "splenic secondary B cell follicle" . [] oboInOwl:hasDbXref "MP:0009199" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004053 ; owl:annotatedTarget "The external masculine genital organs, including the penis and scrotum." . [] oboInOwl:hasDbXref "BTO:0003097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004053 ; owl:annotatedTarget "external male genital organ" . [] oboInOwl:hasDbXref "FMA:45642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004053 ; owl:annotatedTarget "male external genitalia" . [] oboInOwl:hasDbXref "BTO:0003097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004053 ; owl:annotatedTarget "organa genitalia masculina externa" . [] oboInOwl:hasDbXref "MP:0009205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004054 ; owl:annotatedTarget "The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands." . [] oboInOwl:hasDbXref "BTO:0003096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004054 ; owl:annotatedTarget "internal male genital organ" . [] oboInOwl:hasDbXref "FMA:45655" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004054 ; owl:annotatedTarget "male internal genitalia" . [] oboInOwl:hasDbXref "BTO:0003096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004054 ; owl:annotatedTarget "organa genitalia masculina interna" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget _:genid133033 . [] oboInOwl:hasDbXref "BTO:0002840", "MP:0009494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "In ZFA, Digestive system duct that collects bile from the canaliculus and transports bile through the liver -- (check if the same) // The smallest and the most peripheral branches of the biliary tree consist of a portal part (portal ductule) and an intralobular part (intralobular ductule)" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "EMAPA:37440" . [] oboInOwl:hasDbXref "BTO:0002840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "bile ductule" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?ductuli+biliferi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "biliary ductule" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?ductuli+biliferi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "ductuli biliferi" . [] oboInOwl:hasDbXref "BTO:0002840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "bile capillary" . [] oboInOwl:hasDbXref "BTO:0002840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "biliary ductule" . [] oboInOwl:hasDbXref "BTO:0002840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "cholangiole" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004058 ; owl:annotatedTarget "terminal cholangiole" . [] oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget obo:UBERON_0034706 . [] oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget _:genid133049 . [] oboInOwl:hasDbXref "MP:0009689", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." . [] oboInOwl:source "MP:0009689" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "The layer of undifferentiated, proliferating cells that line the neural tube lumen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "(4-hydroxyphenyl)pyruvic acid" . [] oboInOwl:hasDbXref "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "ependymal layer" . [] oboInOwl:hasDbXref "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "neural tube ependymal layer" . [] oboInOwl:hasDbXref "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "neural tube ventricular germinal zone" . [] oboInOwl:hasDbXref "MP:0009689" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "neural tube ventricular zone" . [] oboInOwl:hasDbXref "MP:0009689" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004060 ; owl:annotatedTarget "neural tube ependymal zone" . [] oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004061 ; owl:annotatedTarget obo:UBERON_0034707 . [] oboInOwl:notes "by division" ; oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004061 ; owl:annotatedTarget _:genid133060 . [] oboInOwl:hasDbXref "MP:0009690", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004061 ; owl:annotatedTarget "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." . [] oboInOwl:hasDbXref "MP:0009690", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004061 ; owl:annotatedTarget "neural tube intermediate zone" . [] oboInOwl:hasDbXref "EMAPA:35360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004061 ; owl:annotatedTarget "future brain marginal layer" . [] oboInOwl:notes "forms from axons" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004062 ; owl:annotatedTarget _:genid133068 . [] oboInOwl:hasDbXref "MP:0009691", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004062 ; owl:annotatedTarget "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." . [] oboInOwl:hasDbXref "MP:0009691" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004062 ; owl:annotatedTarget "neural tube marginal zone" . [] oboInOwl:gene "Shh" ; oboInOwl:source "Swenson" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004064 ; owl:annotatedTarget _:genid133076 . [] oboInOwl:hasDbXref "MP:0009693", "Wikipedia:Basal_plate_(neural_tube)", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004064 ; owl:annotatedTarget "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." . [] oboInOwl:source "ncithesaurus:Basal_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004064 ; owl:annotatedTarget "UMLS:C1511061" . [] oboInOwl:hasDbXref "Wikipedia:Basal_plate_(neural_tube)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004064 ; owl:annotatedTarget "basal plate of neural tube" . [] oboInOwl:hasDbXref "MP:0009693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004064 ; owl:annotatedTarget "spinal cord basal plate" . [] oboInOwl:hasDbXref "MP:0009901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." . [] oboInOwl:source "ncithesaurus:Frontonasal_Prominence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "UMLS:C1517321" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "embryonic frontonasal prominence" . [] oboInOwl:hasDbXref "MP:0009901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "forebrain prominence" . [] oboInOwl:hasDbXref "MP:0009901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "frontonasal mass" . [] oboInOwl:hasDbXref "MP:0009901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "frontonasal process" . _:genid131934 oboInOwl:hasDbXref "Wikipedia:Frontonasal_prominence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004066 ; owl:annotatedTarget "prominentia frontonasalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004464 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget _:genid133091 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget _:genid133093 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget obo:UBERON_0004068 . [] oboInOwl:hasDbXref "MP:0009902", "Wikipedia:Lateral_nasal_prominence" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget "The lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it." . [] oboInOwl:hasDbXref "EHDAA2:0000916" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget "lateral nasal process" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000813 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "EMAPA:16805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget "latero-nasal process" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget "lateral nasal swelling" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_nasal_prominence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004067 ; owl:annotatedTarget "prominentia nasalis lateralis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget _:genid133101 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget _:genid133104 . [] oboInOwl:hasDbXref "MP:0009903", "Wikipedia:Medial_nasal_prominence" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." . [] oboInOwl:hasDbXref "EHDAA2:0001076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "medial nasal process" . [] oboInOwl:hasDbXref "EMAPA:16808" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "medial-nasal process" . [] oboInOwl:hasDbXref "Wikipedia:Medial_nasal_prominence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "prominentia nasalis medialis" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000813 ; owl:annotatedTarget "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "medial nasal swelling" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004068 ; owl:annotatedTarget "nasomedial prominence" . _:genid131953 oboInOwl:source "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget _:genid133112 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001096 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget _:genid133114 . [] oboInOwl:hasDbXref "MP:0003511" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget "One of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening." . [] oboInOwl:source "ncithesaurus:Labium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget "UMLS:C0227759" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget "genital labia" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget "labia" . [] oboInOwl:hasDbXref "MA:0002464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004084 ; owl:annotatedTarget "labium" . [] oboInOwl:notes "posterior labial commissure" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004085 ; owl:annotatedTarget _:genid133122 . [] oboInOwl:hasDbXref "MP:0003515" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004085 ; owl:annotatedTarget "One of the folds of skin which form the outer lips on both sides of the vaginal opening." . [] oboInOwl:source "ncithesaurus:Labium_Majus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004085 ; owl:annotatedTarget "UMLS:C0227760" . [] oboInOwl:hasDbXref "MA:0002844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004085 ; owl:annotatedTarget "labium majorum" . [] oboInOwl:hasDbXref "Wikipedia:Labia_majora", "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004085 ; owl:annotatedTarget "labium majus pudendi" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid." . [] oboInOwl:source "BIRNLEX:1356" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "Organ cavity of the brain which consists of the lateral ventricles, the third and fourth ventricles and the cerebral aqueduct[BIRNLEX:1356]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "FMA draws the distinction between e.g. 'fourth ventricle' and 'cavity of fourth ventricle'. The latter is a cavity, and part of the former, which is a region. The superclass of 'fourth ventricle' is_a 'region of ventricular system of the brain'. We place this class here, although it is not equivalent to ventricles, as it includes ventricle bodies." . [] oboInOwl:source "ncithesaurus:Ventricle_Brain" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "UMLS:C0007799" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "brain ventricles" . [] oboInOwl:hasDbXref "HP:0002118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "cerebral ventricle" . [] oboInOwl:hasDbXref "FMA:78447" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004086 ; owl:annotatedTarget "region of ventricular system of brain" . [] oboInOwl:hasDbXref "Wikipedia:Venae_cavae", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004087 ; owl:annotatedTarget "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." . [] oboInOwl:source "ncithesaurus:Vena_Cava" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004087 ; owl:annotatedTarget "UMLS:C0042460" . [] oboInOwl:hasDbXref "Wikipedia:Venae_cavae" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004087 ; owl:annotatedTarget "venae cavae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." . [] oboInOwl:external_ontology "HP:0000284" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "in HP covers eyelid, eyebrow." . [] oboInOwl:hasDbXref "FMA:260119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "content of orbital part of eye" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "eye region" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "orbital part of face" . [] oboInOwl:hasDbXref "FMA:260119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "orbital content" . [] oboInOwl:hasDbXref "FMA:72951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004088 ; owl:annotatedTarget "orbital part of eye" . [] oboInOwl:hasDbXref "HP:0000309", "http://www.merriam-webster.com/medical/midface" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004089 ; owl:annotatedTarget "The middle of the face including the nose and its associated bony structures[MW]." . [] oboInOwl:hasDbXref "MA:0001910" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004089 ; owl:annotatedTarget "snout" . [] oboInOwl:hasDbXref "HP:0000606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004090 ; owl:annotatedTarget "." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004090 ; owl:annotatedTarget "does not contain any subparts in FMA. In HP covers eyelid, eyebrow, soft tissue" . [] oboInOwl:hasDbXref "FMA:59351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004090 ; owl:annotatedTarget "periorbita" . [] oboInOwl:hasDbXref "MA:0002875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004090 ; owl:annotatedTarget "periorbital area" . [] oboInOwl:hasDbXref "HP:0000864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004092 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "GAID:238", "HP:0003310", "Wikipedia:Dens_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "The toothlike process on the upper surface of the axis, which articulates with the atlas above[GAID]." . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002314 ; owl:annotatedTarget (obo:RO_0000052 obo:BFO_0000050 ) . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "(p-hydroxyphenyl)pyruvic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000815 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000721" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "Anterior process located between the atlantal cotyles that projects into the foramen magnum of the skull and bears facets that articulate with the lateral walls of the foramen.[AAO]" . [] oboInOwl:source "ncithesaurus:Odontoid_Process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "UMLS:C0028881" . [] oboInOwl:hasDbXref "FMA:24043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "axis dens" . [] oboInOwl:hasDbXref "MA:0002872" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "axis odontoid process" . [] oboInOwl:hasDbXref "MA:0002872" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "cervical vertebra 2 odontoid process" . [] oboInOwl:hasDbXref "EMAPA:26535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "dens" . [] oboInOwl:hasDbXref "FMA:24043", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "dens axis" . [] oboInOwl:hasDbXref "FMA:24043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "dens of axis" . [] oboInOwl:hasDbXref "FMA:24043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "odontoid process" . [] oboInOwl:hasDbXref "FMA:24043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "odontoid process of axis" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000815 ; owl:annotatedTarget "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." . [] oboInOwl:hasDbXref "Wikipedia:Dens_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004096 ; owl:annotatedTarget "odontoid" . [] oboInOwl:hasDbXref "HP:0003832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004098 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "HP:0003943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004099 ; owl:annotatedTarget "Joint cavity shared by all the joints of the elbow. The elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis. All three share a joint cavity which is highly sinuated/scalloped/coved. Joint spaces of the elbow summarizes the joint cavity shared by all three adjoining joints of the elbow joint." . [] oboInOwl:hasDbXref "FMA:38911" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004099 ; owl:annotatedTarget "synovial cavity of elbow joint" . [] oboInOwl:hasDbXref "HP:0004742", "Wikipedia:Collecting_duct_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004100 ; owl:annotatedTarget "The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone." . [] oboInOwl:hasDbXref "Wikipedia:Collecting_duct_system" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004100 ; owl:annotatedTarget "collecting duct system" . [] oboInOwl:hasDbXref "Wikipedia:Collecting_duct_system" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004100 ; owl:annotatedTarget "kidney collecting duct system" . [] oboInOwl:hasDbXref "Wikipedia:Collecting_duct_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004100 ; owl:annotatedTarget "tubulus renalis colligens" . [] oboInOwl:hasDbXref "HP:0005289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004101 ; owl:annotatedTarget "." . [] oboInOwl:source "PMID:19767574", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget _:genid133191 . [] oboInOwl:hasDbXref "HP:0006477", "Wikipedia:Alveolar_ridge" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "One of the two jaw ridges either on the roof of the mouth between the upper teeth and the hard palate or on the bottom of the mouth behind the lower teeth[WP]. The alveolar ridges contain the sockets (alveoli) of the teeth[HP]." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "in BTO, this is part of an embryo" . [] oboInOwl:source "ncithesaurus:Alveolar_Ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "UMLS:C0447411" . [] oboInOwl:hasDbXref "MP:0004189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "alveolar body" . [] oboInOwl:hasDbXref "MP:0004189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "alveolar bone" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004103 ; owl:annotatedTarget "margo alveolaris" . [] oboInOwl:hasDbXref "Wikipedia:Hairline" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004104 ; owl:annotatedTarget "Anatomical line demarcating the boundary between forehead and scalp." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004105 ; owl:annotatedTarget "Region beneath a nail or claw." . [] oboInOwl:source "Wikipedia-uncited" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004106 ; owl:annotatedTarget _:genid133210 . [] oboInOwl:hasDbXref "HP:0009895" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004106 ; owl:annotatedTarget "Horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear." . [] oboInOwl:source "ncithesaurus:Crus_Helicis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004106 ; owl:annotatedTarget "UMLS:C0229319" . [] oboInOwl:hasDbXref "FMA:61024", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004106 ; owl:annotatedTarget "crus helicis" . [] oboInOwl:hasDbXref "FMA:61024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004106 ; owl:annotatedTarget "crus of helix" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget _:genid133217 . [] oboInOwl:source "HP:0010558" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget _:genid133219 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget _:genid133221 . [] oboInOwl:hasDbXref "HP:0010558", "Wikipedia:Clivus_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "Part of the cranium, the clivus is a shallow depression behind the dorsum sellC& that slopes obliquely backward. It forms a gradual sloping process at the anterior most portion of the basilar occipital bone at its junction with the sphenoid bone. On axial planes, it sits just posterior to the sphenoid sinuses. Just lateral to the clivus bilaterally is the foramen lacerum which contains the internal carotid artery, proximal to its anastamosis with the Circle of Willis. Posterior to the clivus is the basilar artery. The clivus supports the upper part of the pons." . [] oboInOwl:source "ncithesaurus:Clivus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "UMLS:C0222724" . [] oboInOwl:hasDbXref "HP:0010558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "clivus" . [] oboInOwl:hasDbXref "FMA:75747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "occipital bone clivus" . [] oboInOwl:hasDbXref "Wikipedia:Clivus_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "Wackenheim's clivus line" . [] oboInOwl:hasDbXref "FMA:75747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004108 ; owl:annotatedTarget "clivus ossis occipitalis" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004109 ; owl:annotatedTarget "The outer or sperficial part of the humerus." . [] oboInOwl:hasDbXref "FMA:31542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004109 ; owl:annotatedTarget "compact bone of humerus" . [] oboInOwl:hasDbXref "HP:0010641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004110 ; owl:annotatedTarget "An anatomical cavity that is the combination of the cavity between the nares and the choanae[HP,modified]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004111 ; owl:annotatedTarget "Any tube, opening or passage that connects two distinct anatomical spaces." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004111 ; owl:annotatedTarget "FMA has both conduit and conduit space. In EHDAA2 this is a surface feature" . [] oboInOwl:hasDbXref "EHDAA2:0003080" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004111 ; owl:annotatedTarget "foramen" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004111 ; owl:annotatedTarget "foramina" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004111 ; owl:annotatedTarget "ostia" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget obo:UBERON_0002376 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "A muscle of the tympanic cavity that attaches to an auditory ossicle." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "EMAPA:37776" . [] oboInOwl:source "ncithesaurus:Muscle_of_the_Tympanum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "UMLS:C1513769" . [] oboInOwl:hasDbXref "FMA:49026" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "auditory ossicles muscle" . [] oboInOwl:hasDbXref "FMA:49026" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "muscle of auditory ossicles" . [] oboInOwl:hasDbXref "FMA:49026" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "ossicular muscle" . [] oboInOwl:hasDbXref "MA:0000256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004113 ; owl:annotatedTarget "tympanic cavity muscle" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "3-(4-HYDROXY-PHENYL)PYRUVIC ACID" . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget obo:UBERON_0010064 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget _:genid133273 . [] oboInOwl:hasDbXref "Wikipedia:Tympanic_cavity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "Small cavity surrounding the bones of the middle ear." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "EMAPA:37778" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "anatomical cavity of middle ear" . [] oboInOwl:hasDbXref "Wikipedia:Tympanic_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "cavitas tympani" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "cavity of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "middle ear cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "middle-ear cavity" . [] oboInOwl:hasDbXref "BTO:0002098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "cavitas tympanica" . [] oboInOwl:hasDbXref "BTO:0002098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004114 ; owl:annotatedTarget "tympanum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "A blood vessel that is part of a tympanic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "EMAPA:37775" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "anatomical cavity of middle ear blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "blood vessel of anatomical cavity of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "blood vessel of cavity of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "blood vessel of middle ear anatomical cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "blood vessel of middle ear cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "cavity of middle ear blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "middle ear anatomical cavity blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004115 ; owl:annotatedTarget "middle ear cavity blood vessel" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000816 ; owl:annotatedTarget "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "A nerve that is part of a tympanic cavity [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "EMAPA:37777" . _:genid132137 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "anatomical cavity of middle ear nerve" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:PR_000007636 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "cavity of middle ear nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "middle ear anatomical cavity nerve" . [] oboInOwl:hasDbXref "ISBN:781735149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000816 ; owl:annotatedTarget "newly formed B cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "middle ear cavity nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "nerve of anatomical cavity of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "nerve of cavity of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "nerve of middle ear anatomical cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "nerve of middle ear cavity" . [] oboInOwl:hasDbXref "MA:0001222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004116 ; owl:annotatedTarget "tympanic cavity nerves" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget _:genid133319 . [] oboInOwl:hasDbXref "PMID:23020903", "ZFA:0001106", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001106" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "Outpocketings of pharyngeal endoderm that interdigitate with the neural crest derived pharyngeal arches. The pouches later fuse with the surface ectoderm to form the gill slits. Crump et al, 2004.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001203" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "EMAPA also includes a distinct pouch endoderm" . [] oboInOwl:source "ncithesaurus:Pharyngeal_Pouch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "UMLS:C0231067" . [] oboInOwl:hasDbXref "Wikipedia:Branchial_pouch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "branchial pouch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "visceral pouch" . [] oboInOwl:hasDbXref "VHOG:0001203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "pharyngeal pouches" . [] oboInOwl:hasDbXref "VHOG:0001203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004117 ; owl:annotatedTarget "visceral pouches" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004118 ; owl:annotatedTarget "A vasculature that is part of a iris [Automatically generated definition]." . [] oboInOwl:hasDbXref "ZFA:0005568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004118 ; owl:annotatedTarget "iris blood vessels" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004118 ; owl:annotatedTarget "iris vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004118 ; owl:annotatedTarget "vascular network of iris" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004119 ; owl:annotatedTarget "An anatomical structure that develops (entirely or partially) from the endoderm." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004120 ; owl:annotatedTarget "An anatomical structure that develops (entirely or partially) from the mesoderm." . [] oboInOwl:hasDbXref "FBbt:00025998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004120 ; owl:annotatedTarget "mesodermal derivative" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004121 ; owl:annotatedTarget "An anatomical structure that develops (entirely or partially) from the ectoderm." . [] oboInOwl:hasDbXref "FBbt:00025990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004121 ; owl:annotatedTarget "ectodermal deriviative" . [] oboInOwl:hasDbXref "VHOG:0000286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000624" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000624" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "relationship type change: differentiates_from intermediate mesoderm (AAO:0010575) CHANGED TO: develops_from intermediate mesoderm (UBERON:0003064)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000286" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.633", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "Kidneys and gonads (of vertebrates) develop from adjacent tissues, and after the excretory or urinary ducts have developed, the reproductive system usually taps into them or their derivatives.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Genitourinary_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "UMLS:C0042066" . [] oboInOwl:hasDbXref "BTO:0003091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "Urogenitalsystem" . [] oboInOwl:hasDbXref "FMA:280610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "genito-urinary system" . [] oboInOwl:hasDbXref "BTO:0003091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004122 ; owl:annotatedTarget "urogenital tract" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "3-(4-hydroxyphenyl)pyruvic acid" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004123 ; owl:annotatedTarget "Any of the layers of the myocardium. Example: compact layer, trabecular layer." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004123 ; owl:annotatedTarget "EMAPA:37475" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000817 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "ZFA:0005059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005059" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the the endocardium. Unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae of the zebrafish have more strut-like character, and are more uniform without apparent regional differences Hu et al. 2001.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0005059" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "trabecular layer" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "heart muscle trabeculae" . _:genid132217 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "myocardial trabeculae carneae" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006241 . [] oboInOwl:hasDbXref "TAO:0005059" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004124 ; owl:annotatedTarget "trabeculae" . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000817 ; owl:annotatedTarget "A precursor B cell is a B cell with the phenotype CD10-positive." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget _:genid133393 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget _:genid133395 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget "A myocardium trabecular layer that is part of a cardiac ventricle." . [] oboInOwl:hasDbXref "FMA:83511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget "myocardium of region of ventricle" . [] oboInOwl:hasDbXref "GO:0003222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget "trabecular cardiac ventricle muscle" . [] oboInOwl:hasDbXref "GO:0003222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004126 ; owl:annotatedTarget "ventricular trabecular myocardium" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget _:genid133401 . [] oboInOwl:source "GO-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget _:genid133403 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget _:genid133405 . [] oboInOwl:hasDbXref "GO:0003404", "Wikipedia:Optic_vesicles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000165" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" . _:genid132235 oboInOwl:source "ncithesaurus:Optic_Vesicle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "UMLS:C0231106" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 . [] oboInOwl:hasDbXref "XAO:0000228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "eye vesicle" . [] oboInOwl:hasDbXref "VHOG:0000165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "ocular vesicle" . [] oboInOwl:hasDbXref "ZFA:0000050" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004128 ; owl:annotatedTarget "optic vesicles" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:Cortical_Cell_Layer_of_the_Cerebellum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004130 ; owl:annotatedTarget "A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo." . [] oboInOwl:source "ncithesaurus:Cortical_Cell_Layer_of_the_Cerebellum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004130 ; owl:annotatedTarget "UMLS:C1707522" . [] oboInOwl:hasDbXref "BIRNLEX:880" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004130 ; owl:annotatedTarget "cytoarchitectural part of the cerebellar cortex" . [] oboInOwl:hasDbXref "FMA:83141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004130 ; owl:annotatedTarget "gray matter layer of cerebellum" . _:genid132250 oboInOwl:hasDbXref "GO:0021751" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004133 ; owl:annotatedTarget "." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "GO:0021751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004133 ; owl:annotatedTarget "salivary nucleus" . [] oboInOwl:hasDbXref "GO:0003142" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004139 ; owl:annotatedTarget "The first recognizable structure derived from the heart field." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000975" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:15611355 Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE, Basics of cardiac development for the understanding of congenital heart malformations. Pediatric Research (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004139 ; owl:annotatedTarget "(In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004139 ; owl:annotatedTarget "myocardial plate" . [] oboInOwl:hasDbXref "EMAPA:16106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004139 ; owl:annotatedTarget "cardiac crescent" . [] oboInOwl:hasDbXref "GO:0003142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004139 ; owl:annotatedTarget "cardiogenic crescent" . [] oboInOwl:source "GO:0003128" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget _:genid133434 . _:genid132260 oboInOwl:source "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget _:genid133436 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "GO:0003138", "GOC:mtg_heart", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]" . [] oboInOwl:hasDbXref "XAO:0004185" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "first heart field" . [] oboInOwl:hasDbXref "PMID:17276708", "XAO:0004185" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "primary heart field" . [] oboInOwl:hasDbXref "XAO:0004185" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "FHF" . [] oboInOwl:hasDbXref "XAO:0004185" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "PHF" . [] oboInOwl:hasDbXref "XAO:0004185" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004140 ; owl:annotatedTarget "heart field" . [] oboInOwl:source "ZFA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget _:genid133446 . [] oboInOwl:hasDbXref "GO:0003143", "GOC:mtg_heart" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget "An epithelial tube that will give rise to the mature heart." . [] oboInOwl:source "MP:0012700" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget "the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube." . [] oboInOwl:hasDbXref "GO:0003143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget "embryonic heart tube" . [] oboInOwl:hasDbXref "MP:0012700" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget "endocardial heart tube" . [] oboInOwl:hasDbXref "XAO:0000337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004141 ; owl:annotatedTarget "endocardial tube" . [] oboInOwl:hasDbXref "GO:0003148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004142 ; owl:annotatedTarget "The outflow tract septum is a partition in the outflow tract." . [] oboInOwl:hasDbXref "GO:0003151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004145 ; owl:annotatedTarget "The outflow tract is the portion of the heart through which blood flows into the arteries." . [] oboInOwl:hasDbXref "PMID:20735616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004145 ; owl:annotatedTarget "cardiac outflow tract" . [] oboInOwl:hasDbXref "PMID:20735616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004145 ; owl:annotatedTarget "arterial (outflow) pole" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget obo:UBERON_0013140 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "Vein of heart that drains the myocardium." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "EMAPA:37137" . [] oboInOwl:source "ncithesaurus:Cardiac_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "UMLS:C0226654" . [] oboInOwl:source "ncithesaurus:Coronary_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "UMLS:C0226737" . [] oboInOwl:hasDbXref "FMA:12846" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "cardiac vein" . [] oboInOwl:hasDbXref "ZFA:0005814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "coronary vein" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "3-(p-hydroxyphenyl)-2-oxopropanoic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "heart vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "vein of heart" . [] oboInOwl:hasDbXref "Wikipedia:Coronary_circulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004148 ; owl:annotatedTarget "coronary vein" . [] oboInOwl:hasDbXref "GO:0003205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004151 ; owl:annotatedTarget "A cardiac chamber surrounds an enclosed cavity within the heart." . [] oboInOwl:notes "todo check other taxa" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004160 ; owl:annotatedTarget _:genid133483 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004160 ; owl:annotatedTarget _:genid133485 . [] oboInOwl:hasDbXref "GO:0003342", "http://en.wiktionary.org/wiki/proepicardium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004160 ; owl:annotatedTarget "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." . [] oboInOwl:hasDbXref "ZFA:0005808" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004160 ; owl:annotatedTarget "proepicardial cluster" . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-080218-16" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004160 ; owl:annotatedTarget "proepicardial organ" . [] oboInOwl:hasDbXref "VHOG:0000019", "Wikipedia:Septum_transversum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000019" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/transverse+septum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000019" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum" . [] oboInOwl:source "ncithesaurus:Septum_Transversum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "UMLS:C0231004" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004161 ; owl:annotatedTarget "transverse septum" . [] oboInOwl:hasDbXref "GO:0035260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004175 ; owl:annotatedTarget "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." . [] oboInOwl:hasDbXref "GO:0035261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004176 ; owl:annotatedTarget "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." . [] oboInOwl:hasDbXref "GOC:Obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "Organ that is part of the hematopoietic system." . [] oboInOwl:source "http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "the FMA class 'lymphoid organ' is a general anatomical term" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "EMAPA:37665" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "haematological system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "haemopoietic system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "hematopoietic system organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "organ of haematological system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "organ of haemopoietic system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "organ of hematopoietic system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "organ of organa haemopoietica" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "organa haemopoietica organ" . [] oboInOwl:hasDbXref "MA:0000747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "lymph organ" . [] oboInOwl:hasDbXref "BTO:0004605", "FMA:7143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004177 ; owl:annotatedTarget "lymphoid organ" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004178 ; owl:annotatedTarget "The nonstriated, involuntary muscle tissue located in the wall of the aorta." . [] oboInOwl:source "ncithesaurus:Aorta_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004178 ; owl:annotatedTarget "UMLS:C1706825" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004178 ; owl:annotatedTarget "aorta non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004178 ; owl:annotatedTarget "aorta smooth muscle" . [] oboInOwl:hasDbXref "BTO:0001685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004178 ; owl:annotatedTarget "aortic smooth muscle" . [] oboInOwl:hasDbXref "GO:0060611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "adipose tissue of lactiferous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "adipose tissue of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fat tissue of lactiferous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fat tissue of lobe of breast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fat tissue of lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fat tissue of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fatty tissue of lactiferous gland" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget obo:CL_0001201 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fatty tissue of lobe of breast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fatty tissue of lobe of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "fatty tissue of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lactiferous gland adipose tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lactiferous gland fat tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lactiferous gland fatty tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of breast adipose tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of breast fat tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of breast fatty tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of mammary gland adipose tissue" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12810111", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of mammary gland fat tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "lobe of mammary gland fatty tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "mammary gland adipose tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "mammary gland fat tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004180 ; owl:annotatedTarget "mammary gland fatty tissue" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000818 ; owl:annotatedTarget "transitional B cell" . [] oboInOwl:hasDbXref "MP:0013725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004182 ; owl:annotatedTarget "The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis." . [] oboInOwl:hasDbXref "GO:0060716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "blood vessel of labyrinthine layer" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "blood vessel of labyrinthine layer of placenta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "blood vessel of placenta labyrinth" . [] oboInOwl:hasDbXref "GO:0060716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "labyrinthine layer blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "labyrinthine layer of placenta blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004183 ; owl:annotatedTarget "placenta labyrinth blood vessel" . [] oboInOwl:hasDbXref "GO:0060741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." . [] oboInOwl:source "ncithesaurus:Prostatic_Stroma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "UMLS:C1521760" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "prostate stroma" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "4-hydroxy alpha-oxobenzenepropanoic acid" . [] oboInOwl:hasDbXref "FMA:45719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "prostatic stroma" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "stroma of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "stroma of prostate gland" . [] oboInOwl:hasDbXref "FMA:74349", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004184 ; owl:annotatedTarget "stroma of glandular part of prostate" . [] oboInOwl:hasDbXref "GO:0061031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004185 ; owl:annotatedTarget "A portions of the gut that is derived from endoderm." . [] oboInOwl:hasDbXref "EMAPA:32930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004185 ; owl:annotatedTarget "gut endoderm" . [] oboInOwl:hasDbXref "GO:0072010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004188 ; owl:annotatedTarget "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." . [] oboInOwl:hasDbXref "MA:0002847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004188 ; owl:annotatedTarget "kidney glomerular epithelium" . [] oboInOwl:hasDbXref "BTO:0001515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004188 ; owl:annotatedTarget "glomerular epithelial cell" . [] oboInOwl:hasDbXref "GO:0072011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004189 ; owl:annotatedTarget "The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004189 ; owl:annotatedTarget "endothelium of renal glomerulus" . _:genid132426 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004189 ; owl:annotatedTarget "renal glomerulus endothelium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000459 . (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000074 ] ) . [] oboInOwl:hasDbXref "GO:0072012" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "glomerulus vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "renal glomerulus vascular network" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "renal glomerulus vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "vascular network of renal glomerulus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004190 ; owl:annotatedTarget "vasculature of renal glomerulus" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004198 ; owl:annotatedTarget _:genid133617 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004198 ; owl:annotatedTarget _:genid133619 . [] oboInOwl:hasDbXref "GO:0072049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004198 ; owl:annotatedTarget "The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004198 ; owl:annotatedTarget "CSB" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004199 ; owl:annotatedTarget _:genid133623 . _:genid132442 oboInOwl:source "GO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004199 ; owl:annotatedTarget _:genid133625 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 . [] oboInOwl:hasDbXref "GO:0072050" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004199 ; owl:annotatedTarget "The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004199 ; owl:annotatedTarget "SSB" . [] oboInOwl:hasDbXref "http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004199 ; owl:annotatedTarget "stage II nephron" . [] oboInOwl:hasDbXref "GO:0072056", "http://anatomy.uams.edu/anatomyhtml/kidney.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "not the same as FMA:50609 Pyramid (which is a volume / dimensional entity)" . [] oboInOwl:hasDbXref "GO:0072056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "pyramid" . [] oboInOwl:source "ncithesaurus:Renal_Pyramid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "UMLS:C0227629" . [] oboInOwl:source "ncithesaurus:Pyramid_of_Malpighi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "UMLS:C1514613" . [] oboInOwl:hasDbXref "Wikipedia:Renal_pyramids" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "Malpighian pyramid" . [] oboInOwl:hasDbXref "Wikipedia:Renal_pyramids" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "renal pyramid" . _:genid132455 oboInOwl:hasDbXref "BTO:0003926" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "Malphigian pyramid" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0003975 . [] oboInOwl:hasDbXref "ncithesaurus:Pyramid_of_Malpighi" ; oboInOwl:hasSynonymType core:MISSPELLING ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "pyramid of Malphigi" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "pyramid of Malpighi" . [] oboInOwl:hasDbXref "Wikipedia:Renal_pyramids" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "pyramides renales" . [] oboInOwl:hasDbXref "BTO:0003926" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "pyramis renalis" . [] oboInOwl:hasDbXref "FMA:258870" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004200 ; owl:annotatedTarget "renal medullary region" . [] oboInOwl:hasDbXref "GO:0072059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004203 ; owl:annotatedTarget "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." . [] oboInOwl:hasDbXref "MA:0002600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004203 ; owl:annotatedTarget "kidney cortex collecting duct" . _:genid132469 oboInOwl:hasDbXref "MA:0002600" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004203 ; owl:annotatedTarget "renal cortex collecting duct" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 . [] oboInOwl:hasDbXref "GO:0072061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004205 ; owl:annotatedTarget "The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." . [] oboInOwl:hasDbXref "MA:0002598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004205 ; owl:annotatedTarget "inner renal medulla collecting duct" . [] oboInOwl:hasDbXref "MA:0002598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004205 ; owl:annotatedTarget "kidney inner medulla collecting duct" . [] oboInOwl:hasDbXref "MA:0002598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004205 ; owl:annotatedTarget "papillary collecting duct" . [] oboInOwl:hasDbXref "GO:0072076" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004208 ; owl:annotatedTarget "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004208 ; owl:annotatedTarget "mesenchyme of nephron" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004208 ; owl:annotatedTarget "nephron mesenchyme" . _:genid132489 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004209 ; owl:annotatedTarget obo:UBERON_0007503 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009550 . [] oboInOwl:hasDbXref "GO:0072077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004209 ; owl:annotatedTarget "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." . _:genid132491 oboInOwl:hasDbXref "ZFA:0005586", "http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004209 ; owl:annotatedTarget "stage I nephron" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 . [] oboInOwl:hasDbXref "GO:0072088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004211 ; owl:annotatedTarget "The nephron epithelium is a tissue that covers the surface of a nephron." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004211 ; owl:annotatedTarget "epithelial tissue of nephron" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004211 ; owl:annotatedTarget "epithelium of nephron" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004211 ; owl:annotatedTarget "nephron epithelial tissue" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15999 ; owl:annotatedTarget "p-Hydroxyphenylpyruvic acid" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget _:genid133688 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0011320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005284" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-000824-1", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "Capillary that is part of the renal glomerulus. Glomerular capillary endothelial membranes in zebrafish normally have a fenestrated morphology that is visible at the ultrastructural level.[TAO]" . [] oboInOwl:source "ncithesaurus:Glomerular_Capillary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "UMLS:C0226356" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000819 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "blood capillary of renal glomerulus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "capillary of renal glomerulus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "capillary vessel of renal glomerulus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "renal glomerulus blood capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "renal glomerulus capillary" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "renal glomerulus capillary vessel" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "glomerular capillaries" . [] oboInOwl:hasDbXref "MA:0002587" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004212 ; owl:annotatedTarget "glomerular capillary system" . _:genid132518 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000376 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004479 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GO_REF:0000031", "PMID:11861604", "PMID:20933013", "PMID:21220451", "http://en.wikipedia.org/wiki/B-1_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000819 ; owl:annotatedTarget "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "A nerve that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "EMAPA:37344" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "hind limb stylopod nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "hindlimb stylopod nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "lower extremity stylopod nerve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004214 ; owl:annotatedTarget "thigh RELATED" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004215 ; owl:annotatedTarget "A nerve that is part of a back [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004215 ; owl:annotatedTarget "EMAPA:37268" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004215 ; owl:annotatedTarget "nerve of back" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004216 ; owl:annotatedTarget "A nerve that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004216 ; owl:annotatedTarget "EMAPA:37338" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004217 ; owl:annotatedTarget "A nerve that is part of a forelimb stylopod [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004217 ; owl:annotatedTarget "EMAPA:37337" . (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004218 ; owl:annotatedTarget "A nerve that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004218 ; owl:annotatedTarget "EMAPA:37345" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:76909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "muscle layer of urethra" . [] oboInOwl:hasDbXref "FMA:76909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "muscular coat of urethra" . [] oboInOwl:hasDbXref "FMA:76909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "muscular layer of urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "smooth muscle of urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "smooth muscle tissue of urethra" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "tunica muscularis urethrae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "urethra smooth muscle tissue" . [] oboInOwl:hasDbXref "MA:0001691" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004219 ; owl:annotatedTarget "urethral smooth muscle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000820 ; owl:annotatedTarget obo:CL_0000819 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget _:genid133755 . [] oboInOwl:notes "consider merging" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget _:genid133757 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "involuntary muscle of large intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "large intestine involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "large intestine non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "large intestine smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "non-striated muscle of large intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "smooth muscle of large intestine" . [] oboInOwl:hasDbXref "GOC:add", "PMID:11861604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000820 ; owl:annotatedTarget "A B-1 B cell that has the phenotype CD5-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004220 ; owl:annotatedTarget "smooth muscle tissue of large intestine" . [] oboInOwl:notes "consider merging" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget _:genid133773 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" . [] oboInOwl:source "ncithesaurus:Intestinal_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "UMLS:C1708547" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "bowel involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "bowel non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "bowel smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "bowel smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "intestine involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "intestine non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "intestine smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "involuntary muscle of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "involuntary muscle of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "non-striated muscle of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "non-striated muscle of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "smooth muscle of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "smooth muscle of intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "smooth muscle tissue of bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "smooth muscle tissue of intestine" . [] oboInOwl:hasDbXref "EMAPA:35441" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "intestinal muscularis" . [] oboInOwl:hasDbXref "BTO:0000643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004221 ; owl:annotatedTarget "intestinal smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "involuntary muscle of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "involuntary muscle of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "non-striated muscle of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "non-striated muscle of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "smooth muscle of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "smooth muscle of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "smooth muscle tissue of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "smooth muscle tissue of ventriculus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "stomach involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "stomach non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "stomach smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "ventriculus involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "ventriculus non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "ventriculus smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "ventriculus smooth muscle tissue" . [] oboInOwl:hasDbXref "BTO:0001818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "gastric muscle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000821 ; owl:annotatedTarget obo:CL_0000819 . [] oboInOwl:hasDbXref "MA:0001627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "gastric smooth muscle" . [] oboInOwl:hasDbXref "BTO:0001818" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004222 ; owl:annotatedTarget "stomach muscle" . _:genid132636 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "involuntary muscle of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "non-striated muscle of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "smooth muscle of vagina" . [] oboInOwl:hasDbXref "GOC:add", "PMID:11861604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000821 ; owl:annotatedTarget "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "smooth muscle tissue of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "vagina involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "vagina non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "vagina smooth muscle tissue" . _:genid132644 oboInOwl:hasDbXref "BTO:0004999" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "vaginal smooth muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003921 . [] oboInOwl:hasDbXref "BTO:0004999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004223 ; owl:annotatedTarget "vagina smooth muscle" . _:genid132646 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001041 . ( ) . _:genid132651 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "A muscular coat that is part of a vas deferens [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009497 . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscle layer of deferent duct" . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscle layer of ductus deferens" . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscle layer of vas deferens" . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscular coat of ductus deferens" . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscular layer of ductus deferens" . [] oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "muscularis of vas deferens" . _:genid132658 oboInOwl:hasDbXref "FMA:19239" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "tunica muscularis (ductus deferens)" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010375 . [] oboInOwl:hasDbXref "FMA:19239", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004224 ; owl:annotatedTarget "tunica muscularis ductus deferentis" . _:genid132660 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001004 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001045 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004225 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0001660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004225 ; owl:annotatedTarget "respiratory smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004225 ; owl:annotatedTarget "smooth muscle of respiratory system" . _:genid132667 oboInOwl:hasDbXref "BTO:0001660" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004225 ; owl:annotatedTarget "airway smooth muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010376 . [] oboInOwl:hasDbXref "BTO:0001660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004225 ; owl:annotatedTarget "airway smooth muscle cell" . _:genid132669 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008835 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004226 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004226 ; owl:annotatedTarget "smooth muscle tissue of gastrointestinal system" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0011335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004227 ; owl:annotatedTarget "The smooth muscle tissue surrounding the urothelium of the kidney pelvis." . [] oboInOwl:hasDbXref "EMAPA:28120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004227 ; owl:annotatedTarget "kidney pelvis smooth muscle" . [] oboInOwl:hasDbXref "EMAPA:28120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004227 ; owl:annotatedTarget "renal pelvis smooth muscle" . [] oboInOwl:hasDbXref "FMA:262022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004227 ; owl:annotatedTarget "smooth muscle tissue of renal pelvis" . [] oboInOwl:hasDbXref "EMAPA:28120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004227 ; owl:annotatedTarget "pelvic smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "EMAPA:37791" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "bladder involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "bladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "bladder smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "bladder smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "involuntary muscle of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "involuntary muscle of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "non-striated muscle of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "non-striated muscle of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "smooth muscle of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "smooth muscle of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "smooth muscle tissue of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "smooth muscle tissue of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "urinary bladder involuntary muscle" . [] oboInOwl:hasDbXref "MA:0001697" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "urinary bladder muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "urinary bladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004228 ; owl:annotatedTarget "urinary bladder smooth muscle tissue" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000822 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "bladder neck involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "bladder neck non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "bladder neck smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "bladder neck smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "involuntary muscle of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "involuntary muscle of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "involuntary muscle of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "involuntary muscle of urinary bladder neck" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:11861604", "PMID:20933013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000822 ; owl:annotatedTarget "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "involuntary muscle of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of bladder involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of bladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of bladder smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of bladder smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of urinary bladder involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of urinary bladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of urinary bladder smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "neck of urinary bladder smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "non-striated muscle of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "non-striated muscle of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "non-striated muscle of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "non-striated muscle of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "non-striated muscle of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle tissue of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle tissue of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle tissue of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle tissue of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "smooth muscle tissue of vesical neck" . [] oboInOwl:hasDbXref "FMA:67990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "trigonal muscle" . [] oboInOwl:hasDbXref "FMA:67990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "trigonal muscle of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "urinary bladder neck involuntary muscle" . [] oboInOwl:hasDbXref "MA:0001699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "urinary bladder neck muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "urinary bladder neck non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "urinary bladder neck smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "vesical neck involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "vesical neck non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "vesical neck smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004230 ; owl:annotatedTarget "vesical neck smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "EMAPA:37394" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal part of perineum involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal part of perineum non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal part of perineum smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal part of perineum smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal region involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal region non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal region smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal triangle involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal triangle non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal triangle smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "anal triangle smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "involuntary muscle of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "involuntary muscle of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "involuntary muscle of anal triangle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "non-striated muscle of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "non-striated muscle of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "non-striated muscle of anal triangle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle of anal triangle" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000823 ; owl:annotatedTarget "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle tissue of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle tissue of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004231 ; owl:annotatedTarget "smooth muscle tissue of anal triangle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Lymphatic_Vessel_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "UMLS:C1708791" . [] oboInOwl:hasDbXref "PMID:12457618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000823 ; owl:annotatedTarget "p-NK" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "involuntary muscle of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "involuntary muscle of lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymph vessel involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymph vessel non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymph vessel smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymph vessel smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymphatic vessel involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymphatic vessel non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "lymphatic vessel smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "non-striated muscle of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "non-striated muscle of lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "smooth muscle of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "smooth muscle of lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "smooth muscle tissue of lymph vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004232 ; owl:annotatedTarget "smooth muscle tissue of lymphatic vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "involuntary muscle of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "lower respiratory tract involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "lower respiratory tract non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "lower respiratory tract smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "non-striated muscle of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "smooth muscle of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004233 ; owl:annotatedTarget "smooth muscle tissue of lower respiratory tract" . (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001769 ] ) . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget obo:UBERON_0003386 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "involuntary muscle of iris" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "iridial smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "iris involuntary muscle" . _:genid132827 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "iris non-striated muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "iris smooth muscle tissue" . _:genid132829 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "non-striated muscle of iris" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004368 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "smooth muscle of iris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004234 ; owl:annotatedTarget "smooth muscle tissue of iris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004235 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004235 ; owl:annotatedTarget "EMAPA:37669" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004235 ; owl:annotatedTarget "smooth muscle tissue of mammary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004236 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." . [] oboInOwl:hasDbXref "Wikipedia:Vascular_smooth_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "Smooth muscle found within, and composing the majority of the wall of blood vessels." . [] oboInOwl:source "ncithesaurus:Vascular_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "UMLS:C1519956" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "blood vessel involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "blood vessel non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "blood vessel smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "involuntary muscle of blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "non-striated muscle of blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "smooth muscle of blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "smooth muscle tissue of blood vessel" . [] oboInOwl:hasDbXref "ZFA:0005321" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004237 ; owl:annotatedTarget "vascular smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "involuntary muscle of spleen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "non-striated muscle of spleen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "smooth muscle of spleen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "smooth muscle tissue of spleen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "spleen involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "spleen non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004238 ; owl:annotatedTarget "spleen smooth muscle tissue" . [] oboInOwl:notes "consider merging" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget _:genid134063 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "involuntary muscle of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "involuntary muscle of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "non-striated muscle of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "non-striated muscle of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small bowel involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small bowel non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small bowel smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small bowel smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small intestine involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small intestine non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "small intestine smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "smooth muscle of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "smooth muscle of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "smooth muscle tissue of small bowel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004239 ; owl:annotatedTarget "smooth muscle tissue of small intestine" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Gallbladder_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "UMLS:C1708179" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gall bladder involuntary muscle" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "Beilstein:4655978" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gall bladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gall bladder smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gall bladder smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gallbladder involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "gallbladder non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "involuntary muscle of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "involuntary muscle of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "non-striated muscle of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "non-striated muscle of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "smooth muscle of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "smooth muscle of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "smooth muscle tissue of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "smooth muscle tissue of gallbladder" . [] oboInOwl:hasDbXref "MA:0001635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004240 ; owl:annotatedTarget "biliary smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Bronchus_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "UMLS:C1707055" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchi involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchi non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchi smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchi smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchial trunk involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchial trunk non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchial trunk smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchial trunk smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchus involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchus non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchus smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "involuntary muscle of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "involuntary muscle of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "involuntary muscle of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "non-striated muscle of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "non-striated muscle of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "non-striated muscle of bronchus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle of bronchi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle of bronchial trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle of bronchus" . _:genid132940 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle tissue of bronchi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002037 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle tissue of bronchial trunk" . _:genid132942 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "smooth muscle tissue of bronchus" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005568 . [] oboInOwl:hasDbXref "EMAPA:35195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004242 ; owl:annotatedTarget "bronchial smooth muscle" . _:genid132946 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0002367, obo:UBERON_0005056 . _:genid132948 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget _:genid134137 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004876 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "involuntary muscle of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "involuntary muscle of prostate gland" . [] oboInOwl:hasDbXref "FMA:74245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "muscular tissue of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "non-striated muscle of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "non-striated muscle of prostate gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate gland involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate gland non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate gland smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate non-striated muscle" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:11532393", "PMID:12457618", "PMID:15032583", "PMID:15766674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "prostate smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "smooth muscle of prostate" . _:genid132963 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "smooth muscle of prostate gland" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002329 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "smooth muscle tissue of prostate" . _:genid132965 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "smooth muscle tissue of prostate gland" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004290 . [] oboInOwl:hasDbXref "FMA:74245", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004243 ; owl:annotatedTarget "substantia muscularis prostatae" . [] oboInOwl:hasDbXref "PMID:12457618", "PMID:15032583", "PMID:15766674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "NKP" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "fallopian tube involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "fallopian tube non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "fallopian tube smooth muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "fallopian tube smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "involuntary muscle of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "non-striated muscle of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "smooth muscle of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004245 ; owl:annotatedTarget "smooth muscle tissue of fallopian tube" . [] oboInOwl:hasDbXref "PMID:11532393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "null cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "EMAPA:37708" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "involuntary muscle of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "non-striated muscle of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "outflow tract involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "outflow tract non-striated muscle" . [] oboInOwl:hasDbXref "PMID:11532393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000825 ; owl:annotatedTarget "preNK cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "outflow tract smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "smooth muscle of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004246 ; owl:annotatedTarget "smooth muscle tissue of outflow tract" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004247 ; owl:annotatedTarget "A bone that is part of the dorsal region of an animal." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004247 ; owl:annotatedTarget "EMAPA:37248" . [] oboInOwl:hasDbXref "MA:0000494" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004247 ; owl:annotatedTarget "back bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "Gmelin:362716" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004247 ; owl:annotatedTarget "bone of back" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004247 ; owl:annotatedTarget "dorsal region bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids." . _:genid133008 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "EMAPA:37309" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004041 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "bone of digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "digit of foot bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "digitus pedis bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "digitus pedis bone organ" . [] oboInOwl:hasDbXref "MA:0000646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "foot digit bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "foot digit bone organ" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "hind limb digit bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "toe bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "toe bone organ" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004248 ; owl:annotatedTarget "foot digit bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "EMAPA:37305" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "finger bone" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "fore limb digit bone" . [] oboInOwl:hasDbXref "MA:0000622" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "hand digit bone" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004249 ; owl:annotatedTarget "hand digit bone" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic", "https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004250 ; owl:annotatedTarget "A bone that is part of a forelimb stylopod [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004250 ; owl:annotatedTarget "humerus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "A bone that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of hind limb middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of hind limb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of hindlimb middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of hindlimb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of inferior member middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of inferior member zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of intermediate segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of lower extremity middle limb segment" . _:genid133049 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of lower extremity zeugopod" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0004022 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of lower leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of middle limb segment of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of middle limb segment of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of middle limb segment of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of middle limb segment of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of zeugopod of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of zeugopod of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of zeugopod of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of zeugopod of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone of zeugopod of lower extremity" . _:genid133060 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of hind limb middle limb segment" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004022 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of hind limb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of hindlimb middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of hindlimb zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of inferior member middle limb segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of inferior member zeugopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of intermediate segment of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of lower extremity middle limb segment" . _:genid133068 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of lower extremity zeugopod" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004061 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of lower leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of middle limb segment of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of middle limb segment of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of middle limb segment of inferior member" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of middle limb segment of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of zeugopod of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of zeugopod of hindlimb" . _:genid133076 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of zeugopod of inferior member" ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0002328 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of zeugopod of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "bone organ of zeugopod of lower extremity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hind limb middle limb segment bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hind limb middle limb segment bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hind limb zeugopod bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hind limb zeugopod bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hindlimb middle limb segment bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hindlimb middle limb segment bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hindlimb zeugopod bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "hindlimb zeugopod bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "inferior member middle limb segment bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "inferior member middle limb segment bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "inferior member zeugopod bone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "inferior member zeugopod bone organ" . _:genid133091 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "intermediate segment of free lower limb bone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004066 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "intermediate segment of free lower limb bone organ" . _:genid133093 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "lower extremity middle limb segment bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004066 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "lower extremity middle limb segment bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "lower extremity zeugopod bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "lower extremity zeugopod bone organ" . [] oboInOwl:hasDbXref "MA:0000676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "lower leg bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of hind limb bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of hind limb bone organ" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "Reaxys:4655978" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:12633665", "PMID:16551251", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of hindlimb bone" . _:genid133101 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of hindlimb bone organ" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004066 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of inferior member bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of inferior member bone organ" . _:genid133104 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of lower extremity bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004066 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "middle limb segment of lower extremity bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of hind limb bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of hind limb bone organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of hindlimb bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of hindlimb bone organ" . [] oboInOwl:hasDbXref "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "pre-pro B cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of inferior member bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of inferior member bone organ" . _:genid133112 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of leg bone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000997 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of leg bone organ" . _:genid133114 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of lower extremity bone" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0005056 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004251 ; owl:annotatedTarget "zeugopod of lower extremity bone organ" . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000826 ; owl:annotatedTarget "pre-B cell (Philadelphia nomenclature)" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004252 ; owl:annotatedTarget _:genid134310 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004252 ; owl:annotatedTarget "Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition]." . _:genid133122 oboInOwl:hasDbXref "FMA:22470" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004252 ; owl:annotatedTarget "muscle of thigh" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011755 . [] oboInOwl:hasDbXref "FMA:22470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004252 ; owl:annotatedTarget "thigh muscle" . [] oboInOwl:hasDbXref "MA:0000684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004252 ; owl:annotatedTarget "upper leg muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "Any muscle organ that is part of a skin of body [Automatically generated definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only" . [] oboInOwl:hasDbXref "MA:0003139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "integumental system muscle" . [] oboInOwl:hasDbXref "EMAPA:18187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "muscle of integumental system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "muscle organ of skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004253 ; owl:annotatedTarget "skin muscle organ" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget _:genid134331 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget "Any muscle organ that is part of a forelimb zeugopod (lower arm)[Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget "forearm muscle" . [] oboInOwl:hasDbXref "MA:0000600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget "lower arm muscle" . [] oboInOwl:hasDbXref "FMA:37371" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget "muscle of forearm" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004254 ; owl:annotatedTarget "wing zeugopod muscle" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget _:genid134342 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition]." . [] oboInOwl:hasDbXref "MA:0000606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "muscle of upper arm" . [] oboInOwl:hasDbXref "MA:0000606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "upper arm muscle" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "wing stylopod muscle" . [] oboInOwl:hasDbXref "FMA:37370" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "muscle of arm" . [] oboInOwl:hasDbXref "EMAPA:19107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004255 ; owl:annotatedTarget "skeletal muscle of upper arm" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004256 ; owl:annotatedTarget _:genid134354 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004256 ; owl:annotatedTarget "Any muscle organ that is part of a hindlimb zeugopod (lower leg) [Automatically generated definition]." . [] oboInOwl:hasDbXref "MA:0000678" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004256 ; owl:annotatedTarget "lower leg muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004256 ; owl:annotatedTarget "calf muscle" . [] oboInOwl:hasDbXref "FMA:22471" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004256 ; owl:annotatedTarget "muscle of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "A blood vessel that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "EMAPA:37299" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "blood vessel of stylopod of hind limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "blood vessel of stylopod of hindlimb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "blood vessel of thigh" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "blood vessel of upper leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "hind limb stylopod blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "hindlimb stylopod blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004257 ; owl:annotatedTarget "thigh blood vessel" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000827 ; owl:annotatedTarget obo:CL_0000838 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004258 ; owl:annotatedTarget "A blood vessel that is part of a back [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004258 ; owl:annotatedTarget "EMAPA:37243" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004258 ; owl:annotatedTarget "blood vessel of back" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000827 ; owl:annotatedTarget "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004259 ; owl:annotatedTarget "A blood vessel that is part of a lower arm [Automatically generated definition]." . _:genid133191 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004259 ; owl:annotatedTarget "EMAPA:37295" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0008969 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004259 ; owl:annotatedTarget "forelimb zeugopod blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004260 ; owl:annotatedTarget "A blood vessel that is part of a forelimb stylopod [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004260 ; owl:annotatedTarget "EMAPA:37294" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004260 ; owl:annotatedTarget "forelimb stylopod blood vessel" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "(2R)-2-hydroxypropanoate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004261 ; owl:annotatedTarget "A blood vessel that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004261 ; owl:annotatedTarget "EMAPA:37300" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004261 ; owl:annotatedTarget "hindlimb zeugopod blood vessel" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "A zone of skin that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "hind limb stylopod skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "hindlimb stylopod skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "skin of upper leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "skin of thigh" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004262 ; owl:annotatedTarget "thigh skin" . _:genid133217 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000014 _:genid133219 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001676 . _:genid133219 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0003822, obo:UBERON_0008788 . _:genid133221 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004263 ; owl:annotatedTarget "A zone of skin that is part of a forelimb stylopod [Automatically generated definition]." ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001677 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004263 ; owl:annotatedTarget "arm stylopod skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004263 ; owl:annotatedTarget "skin of arm stylopod" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004263 ; owl:annotatedTarget "skin of upper arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004264 ; owl:annotatedTarget "A zone of skin that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004264 ; owl:annotatedTarget "hind limb middle limb segment skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004264 ; owl:annotatedTarget "hind limb zeugopod skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "A myocardium that is part of a outflow tract [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000603" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:9187138 Fishman MC, Chien KR, Fashioning the vertebrate heart: earliest embryonic decisions. Development (1997)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "(...) (theme) is how the vertebrate cardiovascular system differs from that of the presumptive evolutionary chordate ancestor. (...) At best we can tell there are two essential new ingredients: (1) vertebrates all have a continuous endothelial lining to the heart and vessels and (2) vertebrates have developed a second chamber in the heart, one designed for generating high systemic blood pressure.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "cardiac muscle of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "heart muscle of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "heart myocardium of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "muscle of heart of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "myocardium of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "outflow tract cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "outflow tract heart muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "outflow tract heart myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004265 ; owl:annotatedTarget "outflow tract muscle of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004266 ; owl:annotatedTarget "A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004266 ; owl:annotatedTarget "EMAPA:37325" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004267 ; owl:annotatedTarget "A portion of connective tissue that is part of a back [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004267 ; owl:annotatedTarget "EMAPA:37256" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004267 ; owl:annotatedTarget "mesenchyne of back" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004268 ; owl:annotatedTarget "A portion of connective tissue that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004268 ; owl:annotatedTarget "EMAPA:37319" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000828 ; owl:annotatedTarget obo:CL_0000839 . _:genid133273 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004269 ; owl:annotatedTarget "A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition]." ; owl:onProperty obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0005625 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004269 ; owl:annotatedTarget "EMAPA:37317" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:7758949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000828 ; owl:annotatedTarget "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004270 ; owl:annotatedTarget "A portion of connective tissue that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004270 ; owl:annotatedTarget "EMAPA:37327" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004271 ; owl:annotatedTarget "A pericardium that is part of a outflow tract [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004271 ; owl:annotatedTarget "EMAPA:37707" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004271 ; owl:annotatedTarget "pericardium of outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "A cranial suture that is part of a cartilaginous joint [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "EMAPA:37463" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "articulatio cartilaginea cranial suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "articulatio cartilaginea cranial sutures" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "articulatio cartilaginea cranial sutures set" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "articulatio cartilaginea cranium suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "articulatio cartilaginea suture of cranium" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "(R)-lactate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cartilaginous joint cranial suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cartilaginous joint cranial sutures" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cartilaginous joint cranial sutures set" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cartilaginous joint cranium suture" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cartilaginous joint suture of cranium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial suture of articulatio cartilaginea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial suture of cartilaginous joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial sutures of articulatio cartilaginea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial sutures of cartilaginous joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial sutures set of articulatio cartilaginea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranial sutures set of cartilaginous joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranium suture of articulatio cartilaginea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "cranium suture of cartilaginous joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "suture of cranium of articulatio cartilaginea" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004273 ; owl:annotatedTarget "suture of cranium of cartilaginous joint" . _:genid133319 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_Epithelium_of_the_Lateral_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "UMLS:C1711323" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelium of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "choroid plexus epithelial tissue of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "choroid plexus epithelium of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "epithelial tissue of choroid plexus of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "epithelium of choroid plexus of lateral ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle chorioid plexus of cerebral hemisphere epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle choroid plexus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle epithelial tissue of choroid plexus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle epithelium of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004274 ; owl:annotatedTarget "lateral ventricle epithelium of choroid plexus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000829 ; owl:annotatedTarget obo:CL_0000835 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "A choroid plexus epithelium that is part of a third ventricle [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "EMAPA:37055" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelial tissue of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelium of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "choroid plexus epithelial tissue of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "choroid plexus epithelium of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "epithelial tissue of chorioid plexus of cerebral hemisphere of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "epithelial tissue of choroid plexus of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "epithelium of chorioid plexus of cerebral hemisphere of third ventricle" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000829 ; owl:annotatedTarget "A myeloblast committed to the basophil lineage." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "epithelium of choroid plexus of third ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle chorioid plexus of cerebral hemisphere epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle chorioid plexus of cerebral hemisphere epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle choroid plexus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle epithelial tissue of choroid plexus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle epithelium of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004275 ; owl:annotatedTarget "third ventricle epithelium of choroid plexus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Choroid_Plexus_Epithelium_of_the_Fourth_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "UMLS:C1707392" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "chorioid plexus of cerebral hemisphere epithelium of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "choroid plexus epithelial tissue of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "choroid plexus epithelium of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "epithelial tissue of choroid plexus of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "epithelium of choroid plexus of fourth ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle chorioid plexus of cerebral hemisphere epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle choroid plexus epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle epithelial tissue of choroid plexus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle epithelium of chorioid plexus of cerebral hemisphere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004276 ; owl:annotatedTarget "fourth ventricle epithelium of choroid plexus" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004277 ; owl:annotatedTarget _:genid134578 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004277 ; owl:annotatedTarget "A muscle that is part of the eye region." . [] oboInOwl:hasDbXref "VSAO:0000026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004288 ; owl:annotatedTarget "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000026" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004288 ; owl:annotatedTarget "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO]" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget obo:UBERON_0000486 . _:genid133393 oboInOwl:source "AEO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget obo:UBERON_0016888 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001083 . [] oboInOwl:source "EHDAA2", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget _:genid134589 . _:genid133395 oboInOwl:hasDbXref "AEO:0000214" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "The bilaminar epithelium formed from the myotome and dermatome." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004784 . [] oboInOwl:source "http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001513" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010572" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "Portion of somites that gives rise to dermis and muscles.[AAO]" . [] oboInOwl:source "http://medical-dictionary.thefreedictionary.com/dermomyotome" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "D-2-hydroxypropanoate" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000676" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1525-142X.2006.05079.x Devoto SH, Stoiber W, Hammond CL, Steinbacher P, Haslett JR, Barresi MJF, Patterson SE, Adiarte EG and Hughes SM, Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Evolution and Development (2006)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG]" . _:genid133401 oboInOwl:source "ncithesaurus:Dermomyotome" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "UMLS:C1511786" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010312 . [] oboInOwl:hasDbXref "VHOG:0000676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "dermamyotome" . _:genid133403 oboInOwl:hasDbXref "VHOG:0000676" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004290 ; owl:annotatedTarget "dermomyotomes" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002346 . _:genid133405 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004291 ; owl:annotatedTarget _:genid134600 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003071 . [] oboInOwl:hasDbXref "GO:0003313" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004291 ; owl:annotatedTarget "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000115" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004291 ; owl:annotatedTarget "The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO]" . [] oboInOwl:hasDbXref "GO:0003313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004291 ; owl:annotatedTarget "heart cone" . [] oboInOwl:hasDbXref "ZFA:0000115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004291 ; owl:annotatedTarget "rudimentary heart" . [] oboInOwl:hasDbXref "GO:0003204", "Wikipedia:Cardiac_skeleton" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." . [] oboInOwl:hasDbXref "EMAPA:36645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "cardiac fibrous skeleton" . [] oboInOwl:hasDbXref "GO:0003204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "heart fibrous skeleton" . [] oboInOwl:hasDbXref "FMA:9496" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "skeleton of heart" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "anulus fibrosus dexter cordis" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "anulus fibrosus sinister cordis" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "trigona fibrosa" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "trigonum fibrosum dextrum cordis" . [] oboInOwl:hasDbXref "Wikipedia:Cardiac_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004292 ; owl:annotatedTarget "trigonum fibrosum sinistrum cordis" . [] oboInOwl:source "NCBIBook:NBK10065" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004293 ; owl:annotatedTarget _:genid134623 . [] oboInOwl:source "NCBIBook:NBK10065" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004293 ; owl:annotatedTarget _:genid134625 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004293 ; owl:annotatedTarget "A nerve that is part of a parasympathetic nervous system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004293 ; owl:annotatedTarget "nerve of parasympathetic nervous system" . ( ) . _:genid133436 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004294 ; owl:annotatedTarget "An endothelium that is part of a glomerular capillary." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036146 . [] oboInOwl:source "ncithesaurus:Endothelium_of_the_Glomerular_Capillary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004294 ; owl:annotatedTarget "UMLS:C0227647" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004294 ; owl:annotatedTarget "renal glomerulus capillary endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004295 ; owl:annotatedTarget "A nerve trunk that is part of a sympathetic nervous system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004295 ; owl:annotatedTarget "nerve trunk of sympathetic nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004295 ; owl:annotatedTarget "nerve trunk of sympathetic part of autonomic division of nervous system" . _:genid133446 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004295 ; owl:annotatedTarget "sympathetic nervous system nerve trunk" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0005498 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004296 ; owl:annotatedTarget "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004296 ; owl:annotatedTarget "EMAPA:37582" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004296 ; owl:annotatedTarget "smooth muscle of lymph vessel of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004297 ; owl:annotatedTarget "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004297 ; owl:annotatedTarget "EMAPA:37573" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004297 ; owl:annotatedTarget "smooth muscle tissue of blood vessel of respiratory system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004300 ; owl:annotatedTarget "Distal-most phalanx within a digit." . [] oboInOwl:hasDbXref "Wikipedia:Distal_phalanges" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004300 ; owl:annotatedTarget "phalanx distalis" . [] oboInOwl:hasDbXref "AAO:0010676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004300 ; owl:annotatedTarget "terminal phalanx" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=67679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004300 ; owl:annotatedTarget "ungual phalanx" . [] oboInOwl:hasDbXref "Wikipedia:Distal_phalanges" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004300 ; owl:annotatedTarget "phalanx distalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004301 ; owl:annotatedTarget "A phalanx located between proximal and distal phalanges." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004301 ; owl:annotatedTarget "Intermediate phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones of the finger and toe which lie in the middle, between the two wrinkly joints. The thumb and big toe do not have intermediate phalanges. In most other vertebrates, they have a corresponding place in their limbs, whether they be paw, wing, hoof or fin" . [] oboInOwl:hasDbXref "AAO:0010677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004301 ; owl:annotatedTarget "penultimate phalanx" . _:genid133483 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003221 _:genid133485 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004161 . _:genid133485 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0003821, obo:UBERON_0004535 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004302 ; owl:annotatedTarget "Proximal-most phalanx within a digit." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004302 ; owl:annotatedTarget "Proximal phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones at the base of a toe or finger, the prominent, knobby ends of which are often called the knuckles. In other vertebrates, proximal phalanges have a similar placement in the corresponding limbs, be they paw, wing or fin. In many species, they are the longest and thickest phalanx ('finger' bone)" . [] oboInOwl:hasDbXref "AAO:0010680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004302 ; owl:annotatedTarget "proximal-most phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "A distal phalanx that is part of a hand digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "2nd digit of hand distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "2nd finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of 2nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of 2nd finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "D-2-hydroxypropionate" . [] oboInOwl:hasDbXref "FMA:23946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:23946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of second digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "distal phalanx of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "hand digit 2 distal phalanx" . [] oboInOwl:hasDbXref "FMA:23946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "second distal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004311 ; owl:annotatedTarget "second finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "A distal phalanx that is part of a hand digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "3rd digit of hand distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "3rd finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of 3rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of 3rd finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:23947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:23947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of third digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "distal phalanx of third finger" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "equine 3rd phalanx of forelimb digit 3" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "equine forelimb distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "hand digit 3 distal phalanx" . [] oboInOwl:hasDbXref "FMA:23947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "third distal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "third finger distal phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "forelimb coffin bone" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "forelimb medial claw of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "forelimb medial claw of ruminant hoof" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "forelimb medial ungual phalanx of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004312 ; owl:annotatedTarget "forelimb pedal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "A distal phalanx that is part of a hand digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "4th digit of hand distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "4th finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of 4th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of 4th finger" . [] oboInOwl:hasDbXref "FMA:23948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:23948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "distal phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:23948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "fourth distal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "fourth finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004313 ; owl:annotatedTarget "hand digit 4 distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "A distal phalanx that is part of a hand digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "5th digit of hand distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "5th finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of 5th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of 5th finger" . [] oboInOwl:hasDbXref "FMA:23949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:23949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "distal phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:23949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "fifth distal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "fifth finger distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004314 ; owl:annotatedTarget "hand digit 5 distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "A distal phalanx that is part of a foot digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:32627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of big toe" . [] oboInOwl:hasDbXref "FMA:32627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of first digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of foot digit 1" . [] oboInOwl:hasDbXref "FMA:32627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of great toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of hallux" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "distal phalanx of pedal digit I" . [] oboInOwl:hasDbXref "FMA:32627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "first distal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "foot digit 1 distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004315 ; owl:annotatedTarget "hallux distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "A distal phalanx that is part of a foot digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "2nd toe distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of 2nd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of foot digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of pedal digit II" . [] oboInOwl:hasDbXref "FMA:32628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of second digit of foot" . [] oboInOwl:hasDbXref "FMA:32628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of second toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "distal phalanx of the 2nd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "foot digit 2 distal phalanx" . [] oboInOwl:hasDbXref "FMA:32628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004316 ; owl:annotatedTarget "second distal phalanx of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16004 ; owl:annotatedTarget "D-lactate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "A distal phalanx that is part of a foot digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "3rd toe distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of 3rd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of foot digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of pedal digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of the 3rd toe" . [] oboInOwl:hasDbXref "FMA:32629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of third digit of foot" . [] oboInOwl:hasDbXref "FMA:32629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "distal phalanx of third toe" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "equine 3rd phalanx of hindlimb digit 3" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "equine hindlimb distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "foot digit 3 distal phalanx" . [] oboInOwl:hasDbXref "FMA:32629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "third distal phalanx of foot" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "hindlimb coffin bone" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "hindlimb medial claw of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "hindlimb medial claw of ruminant hoof" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "hindlimb medial ungual phalanx of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004317 ; owl:annotatedTarget "hindlimb pedal bone" . _:genid133617 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004300 _:genid133619 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010532 . _:genid133619 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003634, obo:UBERON_0004209 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "A distal phalanx that is part of a foot digit 4 [Automatically generated definition]." . _:genid133623 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "4th toe distal phalanx" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010532 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of 4th toe" . _:genid133625 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of foot digit 4" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004198 . [] oboInOwl:hasDbXref "FMA:32630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of fourth digit of foot" . [] oboInOwl:hasDbXref "FMA:32630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of pedal digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "distal phalanx of the 4th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "foot digit 4 distal phalanx" . [] oboInOwl:hasDbXref "FMA:32630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004318 ; owl:annotatedTarget "fourth distal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "A distal phalanx that is part of a foot digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "5th toe distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of 5th toe" . [] oboInOwl:hasDbXref "FMA:32631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:32631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of fifth toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of foot digit 5" . [] oboInOwl:hasDbXref "FMA:32631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of pedal digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "distal phalanx of the 5th toe" . [] oboInOwl:hasDbXref "FMA:32631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "fifth distal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004319 ; owl:annotatedTarget "foot digit 5 distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "A middle phalanx that is part of a hand digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "2nd digit of hand intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "2nd digit of hand middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "2nd finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "2nd finger middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "hand digit 2 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "hand digit 2 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "intermediate phalanx of 2nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "intermediate phalanx of 2nd finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "intermediate phalanx of hand digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "intermediate phalanx of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of 2nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of 2nd finger" . [] oboInOwl:hasDbXref "FMA:23933" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:23933" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of second digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "middle phalanx of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "second finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "second finger middle phalanx" . [] oboInOwl:hasDbXref "FMA:23933" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004320 ; owl:annotatedTarget "second middle phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "A middle phalanx that is part of a hand digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "3rd digit of hand intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "3rd digit of hand middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "3rd finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "3rd finger middle phalanx" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "forelimb digit III P2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "hand digit 3 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "hand digit 3 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "intermediate phalanx of 3rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "intermediate phalanx of 3rd finger" . _:genid133688 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "intermediate phalanx of hand digit 3" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004190 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "intermediate phalanx of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of 3rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of 3rd finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of manual digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:23934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of third digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "middle phalanx of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "third finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "third finger middle phalanx" . [] oboInOwl:hasDbXref "FMA:23934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "third middle phalanx of hand" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004321 ; owl:annotatedTarget "forelimb short pastern bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "A middle phalanx that is part of a hand digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "4th digit of hand intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "4th digit of hand middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "4th finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "4th finger middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "fourth finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "fourth finger middle phalanx" . [] oboInOwl:hasDbXref "FMA:23935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "fourth middle phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "hand digit 4 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "hand digit 4 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "intermediate phalanx of 4th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "intermediate phalanx of 4th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "intermediate phalanx of fourth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "intermediate phalanx of hand digit 4" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of 4th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of 4th finger" . [] oboInOwl:hasDbXref "FMA:23935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of manual digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004322 ; owl:annotatedTarget "middle phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "A middle phalanx that is part of a hand digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "5th digit of hand intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "5th digit of hand middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "5th finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "5th finger middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "fifth finger intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "fifth finger middle phalanx" . [] oboInOwl:hasDbXref "FMA:23936" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "fifth middle phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "hand digit 5 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "hand digit 5 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "intermediate phalanx of 5th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "intermediate phalanx of 5th finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "intermediate phalanx of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "intermediate phalanx of hand digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of 5th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of 5th finger" . [] oboInOwl:hasDbXref "FMA:23936" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of fifth finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004323 ; owl:annotatedTarget "middle phalanx of manual digit V" . _:genid133755 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "A middle phalanx that is part of a foot digit 2 [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001169 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "2nd toe intermediate phalanx" . _:genid133757 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "2nd toe middle phalanx" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0011198 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "foot digit 2 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "foot digit 2 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "intermediate phalanx of 2nd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "intermediate phalanx of foot digit 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of 2nd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of foot digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of pedal digit II" . [] oboInOwl:hasDbXref "FMA:32623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of second digit of foot" . [] oboInOwl:hasDbXref "FMA:32623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of second toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "middle phalanx of the 2nd toe" . [] oboInOwl:hasDbXref "FMA:32623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004324 ; owl:annotatedTarget "second middle phalanx of foot" . _:genid133773 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0012367, obo:UBERON_5103633 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "A middle phalanx that is part of a foot digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "3rd toe intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "3rd toe middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "foot digit 3 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "foot digit 3 middle phalanx" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "hindlimb digit III P2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "intermediate phalanx of 3rd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "intermediate phalanx of foot digit 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of 3rd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of foot digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of pedal digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of the 3rd toe" . [] oboInOwl:hasDbXref "FMA:32624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of third digit of foot" . [] oboInOwl:hasDbXref "FMA:32624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "middle phalanx of third toe" . [] oboInOwl:hasDbXref "FMA:32624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "third middle phalanx of foot" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004325 ; owl:annotatedTarget "hindlimb short pastern bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "A middle phalanx that is part of a pedal digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "4th toe intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "4th toe middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "foot digit 4 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "foot digit 4 middle phalanx" . [] oboInOwl:hasDbXref "FMA:32625" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "fourth middle phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "intermediate phalanx of 4th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "intermediate phalanx of foot digit 4" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of 4th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of foot digit 4" . [] oboInOwl:hasDbXref "FMA:32625" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of fourth digit of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of pedal digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004326 ; owl:annotatedTarget "middle phalanx of the 4th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "A middle phalanx that is part of a pedal digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "5th toe intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "5th toe middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "foot digit 5 intermediate phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "foot digit 5 middle phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "intermediate phalanx of 5th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "intermediate phalanx of foot digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "middle phalanx of 5th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "middle phalanx of foot digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "middle phalanx of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "middle phalanx of pedal digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004327 ; owl:annotatedTarget "middle phalanx of the 5th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "A proximal phalanx that is part of a hand digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "2nd digit of hand proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "2nd finger proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "hand digit 2 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "manual digit 2 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "manual phalanx II-1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of 2nd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of 2nd finger" . [] oboInOwl:hasDbXref "FMA:23919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:23919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of second digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "proximal phalanx of second finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "second finger proximal phalanx" . [] oboInOwl:hasDbXref "FMA:23919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004328 ; owl:annotatedTarget "second proximal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "A proximal phalanx that is part of a hand digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "3rd digit of hand proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "3rd finger proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "hand digit 3 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "manual digit 3 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "manual phalanx III-1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of 3rd digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of 3rd finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:23920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:23920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of third digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "proximal phalanx of third finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "third finger proximal phalanx" . [] oboInOwl:hasDbXref "FMA:23920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004329 ; owl:annotatedTarget "third proximal phalanx of hand" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000831 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "A proximal phalanx that is part of a hand digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "4th digit of hand proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "4th finger proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "fourth finger proximal phalanx" . [] oboInOwl:hasDbXref "FMA:23921" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "fourth proximal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "hand digit 4 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "manual digit 4 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "manual phalanx IV-1" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMCID:PMC1183570", "PMCID:PMC1312421", "PMID:8629001", "PMID:9354811", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000831 ; owl:annotatedTarget "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of 4th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of 4th finger" . [] oboInOwl:hasDbXref "FMA:23921" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:23921" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004330 ; owl:annotatedTarget "proximal phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "A proximal phalanx that is part of a hand digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "5th digit of hand proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "5th finger proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "fifth finger proximal phalanx" . [] oboInOwl:hasDbXref "FMA:23922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "fifth proximal phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "hand digit 5 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "manual digit 5 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "manual phalanx V-1" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "Beilstein:82131" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of 5th digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of 5th finger" . [] oboInOwl:hasDbXref "FMA:23922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:23922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004331 ; owl:annotatedTarget "proximal phalanx of manual digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "foot digit 1 proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "hallux proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "pedal phalanx I-1" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "predal digit 1 proximal phalanx" . [] oboInOwl:hasDbXref "FMA:43252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "proximal phalanx of big toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "proximal phalanx of foot digit 1" . [] oboInOwl:hasDbXref "FMA:43252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "proximal phalanx of great toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "proximal phalanx of hallux" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004332 ; owl:annotatedTarget "proximal phalanx of pedal digit I" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "2nd toe proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "foot digit 2 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "pedal phalanx II-1" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "predal digit 2 proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "proximal phalanx of 2nd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "proximal phalanx of foot digit 2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "proximal phalanx of pedal digit II" . [] oboInOwl:hasDbXref "FMA:32618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "proximal phalanx of second digit of foot" . [] oboInOwl:hasDbXref "FMA:32618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "proximal phalanx of second toe" . [] oboInOwl:hasDbXref "FMA:32618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004333 ; owl:annotatedTarget "second proximal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "3rd toe proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "foot digit 3 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "pedal phalanx III-1" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "predal digit 3 proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "proximal phalanx of 3rd toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "proximal phalanx of foot digit 3" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "proximal phalanx of pedal digit III" . [] oboInOwl:hasDbXref "FMA:32619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "proximal phalanx of third digit of foot" . [] oboInOwl:hasDbXref "FMA:32619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "proximal phalanx of third toe" . [] oboInOwl:hasDbXref "FMA:32619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004334 ; owl:annotatedTarget "third proximal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "4th toe proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "foot digit 4 proximal phalanx" . [] oboInOwl:hasDbXref "FMA:32620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "fourth proximal phalanx of foot" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "pedal phalanx IV-1" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "predal digit 4 proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "proximal phalanx of 4th toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "proximal phalanx of foot digit 4" . [] oboInOwl:hasDbXref "FMA:32620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "proximal phalanx of fourth digit of foot" . [] oboInOwl:hasDbXref "FMA:32620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "proximal phalanx of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004335 ; owl:annotatedTarget "proximal phalanx of pedal digit IV" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "A proximal phalanx that is part of a pedal digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "5th toe proximal phalanx" . [] oboInOwl:hasDbXref "FMA:32621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "fifth proximal phalanx of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "foot digit 5 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "pedal phalanx V-1" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "predal digit 5 proximal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of 5th toe" . [] oboInOwl:hasDbXref "FMA:32621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:32621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of fifth toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of foot digit 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004336 ; owl:annotatedTarget "proximal phalanx of pedal digit V" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "A distal phalanx that is part of a hand digit 1 [Automatically generated definition]." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "The human pollical distal phalanx (PDP) has a pronounced insertion for the flexor pollicis longus (asymmetric towards the radial side), an ungual fossa, and a pair of dissymmetric ungual spines (the ulnar being more prominent). This asymmetry is necessary to ensure that the thumb pulp is always facing the pulps of the other digits, an osteological configuration which provides the maximum contact surface with held objects." . [] oboInOwl:hasDbXref "Wikipedia:Distal_phalanges#Thumb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "PDP" . [] oboInOwl:hasDbXref "FMA:23945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "distal phalanx of first digit of hand" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "CAS:149-87-1" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000835 ; owl:annotatedTarget obo:CL_0002191 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "distal phalanx of manual digit I" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "distal phalanx of thumb" . [] oboInOwl:hasDbXref "FMA:23945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "first distal phalanx of hand" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "manual digit 1 distal phalanx" . [] oboInOwl:hasDbXref "Wikipedia:Distal_phalanges#Thumb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "pollical distal phalanx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004337 ; owl:annotatedTarget "thumb distal phalanx" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000835 ; owl:annotatedTarget "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "A proximal phalanx that is part of a hand digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:23918" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "first proximal phalanx of hand" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "manual digit 1 proximal phalanx" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "manual phalanx I-1" . [] oboInOwl:hasDbXref "FMA:23918" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "proximal phalanx of first digit of hand" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "proximal phalanx of manual digit I" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "proximal phalanx of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004338 ; owl:annotatedTarget "thumb proximal" . [] oboInOwl:notes "small pharyngeal arch and sclerotomal contribution" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget _:genid135220 . [] oboInOwl:hasDbXref "MP:0000076", "PMID:11523816", "Wikipedia:Calvaria_(skull)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "Upper part of skull, consisting of parietals, frontals, post-parietals, and in some species the squamosal and a portion of the alisphenoid." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000331" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.256", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "The earliest tetrapods arose from rhipidistian ancestors and retained many of their skull features, including most of the bones of the dermatocranium.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Skullcap" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "UMLS:C0205950" . [] oboInOwl:hasDbXref "FMA:52800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "calva" . [] oboInOwl:hasDbXref "ZFA:0005606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "cranial vault" . [] oboInOwl:hasDbXref "ZFA:0005606" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "calvaria" . [] oboInOwl:hasDbXref "ZFA:0005606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004339 ; owl:annotatedTarget "skullcap" . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget _:genid135230 . [] oboInOwl:source "Hymans" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget _:genid135232 . [] oboInOwl:notes "hindgut diverticulum endoderm" ; oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget _:genid135234 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget _:genid135236 . [] oboInOwl:hasDbXref "VHOG:0000738", "Wikipedia:Allantois" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000738" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/allantois" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000738" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "part_of embryo in EHDAA2 - note differences in humans" . [] oboInOwl:source "ncithesaurus:Allantois" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "UMLS:C0002084" . [] oboInOwl:hasDbXref "EMAPA:16107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004340 ; owl:annotatedTarget "allantoic bud" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget obo:UBERON_0000485 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget _:genid135245 . [] oboInOwl:hasDbXref "MP:0002231", "Wikipedia:Primitive_streak" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget "The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001202" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:9609826 Wu LH, Lengyel JA, Role of caudal in hindgut specification and gastrulation suggests homology between Drosophila amnioproctodeal invagination and vertebrate blastopore. Development (1998), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.139", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget "(...) the blastopore equivalent of chordates (germ ring in fish, marginal zone/blastopore lip in frog and node/primitive streak in chick and mouse) (...) (reference 1); Indeed, the primitive streak has been considered the homologue of the blastopore since the 1870s (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "VHOG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget "VHOG includes a very broad grouping here based on http://www.ncbi.nlm.nih.gov/pubmed/9609826" . [] oboInOwl:source "ncithesaurus:Primitive_Streak" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget "UMLS:C0033153" . [] oboInOwl:hasDbXref "VHOG:0001202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004341 ; owl:annotatedTarget "primitive streak - blastopore - germ ring" . [] oboInOwl:hasDbXref "MP:0004783" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001197" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.462", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "In primitive vertebrates, the basic early embryonic pattern is retained, and blood from anterior and posterior systemic tissues is returned in anterior and posterior cardinal veins, both pairs of veins uniting in common cardinal veins near the heart. In derived vertebrates, the cardinals appear but usually persist only in the embryo, being functionally replaced by alternative adult vessels, the precava and postcava (anterior and posterior venae cavae).[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cardinal_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "UMLS:C0231085" . [] oboInOwl:hasDbXref "BTO:0004385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "Cuvierian vein" . [] oboInOwl:hasDbXref "BTO:0004385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "cardinal sinus" . [] oboInOwl:hasDbXref "EHDAA2:0000213" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004344 ; owl:annotatedTarget "cardinal vein system" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget _:genid135262 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget _:genid135265 . [] oboInOwl:hasDbXref "MP:0005028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000979" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget "The outer cellular layer of the mammalian blastocyst. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.750, see_Kardong_KV][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000979" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676685 Romer AS, Parsons TS, Vertebrate body (1977) p.105-106", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget "(...) the trophoblast develops rapidly so that contact may be made with the maternal uterine tissues when conditions are appropriate. We have here an excellent example of an embryonic adaptation, the development of a structure never present in either adult or embryo of 'lower' vertebrates.[well established][VHOG]" . _:genid134063 oboInOwl:external_ontology "BTO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004345 ; owl:annotatedTarget "BTO has this has part of the trophoblast" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0011201 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget obo:UBERON_0008845 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget _:genid135272 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget _:genid135276 . [] oboInOwl:hasDbXref "MP:0005149", "Wikipedia:Gubernaculum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "Embryonic structures which begin as undifferentiated mesenchyme attaching to the caudal end of the gonads. The gubernaculum is present only during the development of the urinary and reproductive organs, being replaced by distinct vestiges in males and females[WP]. Enitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus[MP]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "WP def is male/female, split term? EMAP is male-specific. vestigial adult in FMA. TODO" . [] oboInOwl:source "ncithesaurus:Gubernaculum_Testis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "UMLS:C0228051" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "gubernaculum" . [] oboInOwl:hasDbXref "Wikipedia:Gubernaculum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "Gabernaculum" . [] oboInOwl:hasDbXref "EMAPA:19089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "caudal suspensory ligament" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004346 ; owl:annotatedTarget "gubernaculae" . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget _:genid135287 . [] oboInOwl:hasDbXref "ISBN:9780878932504", "MP:0005650", "Wikipedia:Limb_bud", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010375" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "Early outgrowth of presumptive limb.[AAO]" . [] oboInOwl:source "ncithesaurus:Limb_Bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "UMLS:C0282505" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "limb buds" . [] oboInOwl:hasDbXref "GO:0060174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "limbbud" . [] oboInOwl:hasDbXref "Wikipedia:Limb_bud" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004347 ; owl:annotatedTarget "gemmae membrorum" . [] oboInOwl:hasDbXref "MP:0006305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004348 ; owl:annotatedTarget "The embryonic structure that gives rise to the corneal ectoderm." . [] oboInOwl:hasDbXref "MP:0008015", "Wikipedia:Inguinal_canal#Contents" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004353 ; owl:annotatedTarget "An inguinal canal that is part of a female organism. Conveys the round ligament + the ilioinguinal nerve.[WP,unvetted]." . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004353 ; owl:annotatedTarget "in MP, this is implicitly part of female reproductive system, but not female genitalia" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "CAS:149-87-1" . [] oboInOwl:hasDbXref "MP:0008016", "Wikipedia:Inguinal_canal#Contents" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004354 ; owl:annotatedTarget "An inguinal canal that is part of a male organism. Conveys the spermatic cord and its coverings + the ilioinguinal nerve.[WP,unvetted]." . [] oboInOwl:external_ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004354 ; owl:annotatedTarget "in MP, this is implicitly part of male reproductive system, but not male genitalia" . [] oboInOwl:hasDbXref "MP:0001676", "Wikipedia:Apical_ectodermal_ridge" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010760" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002146" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "Proliferative region that is part of the developing fin fold or fin.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002146" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "relationship loss: subclass proliferative region (TAO:0000098)[TAO]" . [] oboInOwl:source "PMID:20574421" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold" . [] oboInOwl:source "ncithesaurus:Apical_Ectodermal_Ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "UMLS:C1516037" . [] oboInOwl:hasDbXref "XAO:0004121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "apical epidermal ridge" . [] oboInOwl:hasDbXref "MP:0001676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "AER" . [] oboInOwl:hasDbXref "Wikipedia:Apical_ectodermal_ridge" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004356 ; owl:annotatedTarget "crista ectodermalis apicalis" . [] oboInOwl:hasDbXref "ISBN:9780878932504", "MP:0005650", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004357 ; owl:annotatedTarget "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001258" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004357 ; owl:annotatedTarget "The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004357 ; owl:annotatedTarget "limb - fin bud" . [] oboInOwl:hasDbXref "VHOG:0001258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004357 ; owl:annotatedTarget "paired limb/fin bud" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010364" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" . [] oboInOwl:source "MP:0006337,MGI:smb" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000296" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:First_Pharyngeal_Arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "UMLS:C1517197" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "branchial arch 1" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "first branchial arch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "first visceral arch" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "visceral arch 1" . [] oboInOwl:hasDbXref "EHDAA2:0000006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "1st arch" . _:genid134137 oboInOwl:hasDbXref "VHOG:0000296" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "1st visceral arch" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_1000487 . [] oboInOwl:hasDbXref "Wikipedia:First_pharyngeal_arch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004362 ; owl:annotatedTarget "arcus pharyngeus primus" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget _:genid135352 . [] oboInOwl:notes "abduced from EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget _:genid135354 . [] oboInOwl:hasDbXref "MP:0002672" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000122" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/aortic+arches" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "Paired vessels arching from the ventral to the dorsal aorta through the pharyngeal arches. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000122" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Aortic_Arch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "UMLS:C0003489" . [] oboInOwl:hasDbXref "MP:0002672" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "PAA" . [] oboInOwl:hasDbXref "ZFA:0005004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "aortic arch" . [] oboInOwl:hasDbXref "ZFA:0005004" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "aortic arches" . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-080512-6" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "branchial aortic arches" . [] oboInOwl:hasDbXref "EMAPA:16684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "branchial arch artery" . [] oboInOwl:hasDbXref "EMAPA:16684", "MP:0002672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "embryonic aortic arch artery" . [] oboInOwl:hasDbXref "MP:0002672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "pharyngeal arch artery" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_arches" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "a. arcuum pharyngeorum" . [] oboInOwl:hasDbXref "EMAPA:16684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "aortic arch artery" . [] oboInOwl:hasDbXref "Wikipedia:Aortic_arches" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "arteriae arcuum pharyngeorum" . [] oboInOwl:hasDbXref "ZFA:0005004", "ZFIN:ZDB-PUB-080512-6" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "branchial aortic arches" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "pharyngeal arch arteries" . [] oboInOwl:hasDbXref "VHOG:0000122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004363 ; owl:annotatedTarget "pharyngeal arch artery" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004365 ; owl:annotatedTarget "Blood vessel that is connected to the yolk sac." . [] oboInOwl:source "Cline et al" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget _:genid135390 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget obo:UBERON_0004370 . [] oboInOwl:hasDbXref "MP:0004285", "https://github.com/obophenotype/uberon/issues/15" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]." . [] oboInOwl:date_retrieved "2016-05-01" ; oboInOwl:external_class "TAO:0002157" ; oboInOwl:ontology "ZFIN" ; oboInOwl:source "ZFIN:ZDB-PUB-061010-3", "https://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN]" . [] oboInOwl:source "ncithesaurus:Descemet_s_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "UMLS:C0011665" . [] oboInOwl:hasDbXref "FMA:58309" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "Descemet's posterior elastic lamina" . [] oboInOwl:hasDbXref "FMA:58309" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "lamina limitans posterior" . [] oboInOwl:hasDbXref "FMA:58309", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "lamina limitans posterior corneae" . [] oboInOwl:hasDbXref "MA:0001246" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "posterior limiting lamina" . [] oboInOwl:hasDbXref "FMA:58309" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "posterior limiting lamina of cornea" . [] oboInOwl:hasDbXref "ZFA:0001686" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004367 ; owl:annotatedTarget "posterior limiting membrane" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget _:genid135402 . [] oboInOwl:hasDbXref "DOI:10.1111/j.1469-7580.2006.00524.x", "MP:0004916" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget "A continuous cartilaginous formation in mesenchyme of the second pharyngeal arch in the embryo. The longer cranial or styloid segment is continuous with the otic capsule; its inferior end is angulated and is situated very close to the oropharynx. The smaller caudal segment is in contact with the body and greater horn of the hyoid cartilaginous structure." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget "in EHDAA2 this also develops from 3rd arch Mes from NC" . [] oboInOwl:hasDbXref "MP:0004916" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget "hyaloid cartilage" . [] oboInOwl:hasDbXref "EHDAA2:0000793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget "hyoid cartilage" . [] oboInOwl:hasDbXref "MP:0004916" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004368 ; owl:annotatedTarget "second pharyngeal arch cartilage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "ncithesaurus:Bowman_s_Membrane" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002155" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-061010-3" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO]" . [] oboInOwl:source "ncithesaurus:Bowman_s_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "UMLS:C0229127" . [] oboInOwl:hasDbXref "FMA:58273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "Bowman's anterior elastic lamina" . [] oboInOwl:hasDbXref "FMA:58273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "Bowman's layer" . [] oboInOwl:hasDbXref "FMA:58273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "Bowman's membrane" . [] oboInOwl:hasDbXref "ZFA:0001684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "anterior elastic lamina" . [] oboInOwl:hasDbXref "MA:0001240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "anterior limiting lamina" . [] oboInOwl:hasDbXref "FMA:58273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "anterior limiting lamina of cornea" . [] oboInOwl:hasDbXref "FMA:58273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "lamina limitans anterior (cornea)" . [] oboInOwl:hasDbXref "FMA:58273", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "lamina limitans anterior corneae" . [] oboInOwl:hasDbXref "http://sourceforge.net/tracker/?func=detail&aid=2956371&group_id=76834&atid=974957" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "Reichert's membrane" . [] oboInOwl:hasDbXref "ZFA:0001684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004370 ; owl:annotatedTarget "anterior limiting membrane" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004374 ; owl:annotatedTarget "Vascular network that is connected to the yolk sac." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004374 ; owl:annotatedTarget "omphalomesenteric system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004374 ; owl:annotatedTarget "vitelline bloos vessel system" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004374 ; owl:annotatedTarget "vitelline system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004375 ; owl:annotatedTarget "A bone that is part of an appendage [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004377 ; owl:annotatedTarget "A metaphysis that is in the distal side of a diaphysis." . [] oboInOwl:hasDbXref "FMA:32824" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004377 ; owl:annotatedTarget "distal diaphyseal end of long bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004378 ; owl:annotatedTarget "A metaphysis that is in the proximal side of a diaphysis." . [] oboInOwl:hasDbXref "FMA:32823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004378 ; owl:annotatedTarget "proximal diaphyseal end of long bone" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004379 ; owl:annotatedTarget "An epiphysis that is on the distal side of the bone." . [] oboInOwl:hasDbXref "FMA:32822" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004379 ; owl:annotatedTarget "distal end of long bone" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004380 ; owl:annotatedTarget "An epiphysis that is on the proximal side of the bone." . [] oboInOwl:hasDbXref "FMA:32821" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004380 ; owl:annotatedTarget "proximal end of long bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004381 ; owl:annotatedTarget "The collection of all skeletal elements in an individual limb." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000300" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004381 ; owl:annotatedTarget "Skeletal subdivision that is part of the limb.[VSAO]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004381 ; owl:annotatedTarget "EHDAA2 considers hip and shoulder joints part of limb skeleton." . [] oboInOwl:hasDbXref "VSAO:0000300" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004381 ; owl:annotatedTarget "free limb skeleton" . [] oboInOwl:hasDbXref "EHDAA2:0002221" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004381 ; owl:annotatedTarget "limb skeleton" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004382 ; owl:annotatedTarget "An epiphysis that is part of a humerus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004382 ; owl:annotatedTarget "humeral epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004383 ; owl:annotatedTarget "An epiphysis that is part of a tibia [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004383 ; owl:annotatedTarget "EMAPA:37771" . [] oboInOwl:hasDbXref "FMA:33112" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004383 ; owl:annotatedTarget "tibial epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004384 ; owl:annotatedTarget "An epiphysis that is part of a femur [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004384 ; owl:annotatedTarget "EMAPA:37539" . [] oboInOwl:hasDbXref "FMA:32838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004384 ; owl:annotatedTarget "femoral epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004385 ; owl:annotatedTarget "An epiphysis that is part of a radius [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004385 ; owl:annotatedTarget "radial epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004386 ; owl:annotatedTarget "An epiphysis that is part of an ulna [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33748" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004386 ; owl:annotatedTarget "ulnar epiphysis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004387 ; owl:annotatedTarget "An epiphysis that is part of a phalanx of a manus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:240707" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004387 ; owl:annotatedTarget "epiphysis of phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004388 ; owl:annotatedTarget "An epiphysis that is part of a fibula [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004388 ; owl:annotatedTarget "fibula epiphysis" . _:genid134310 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001448 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004463 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004389 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004389 ; owl:annotatedTarget "metatarsal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004390 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33792" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004390 ; owl:annotatedTarget "metacarpal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004391 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004391 ; owl:annotatedTarget "first metacarpal bone epiphysis" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004392 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004392 ; owl:annotatedTarget "second metacarpal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004393 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:86328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004393 ; owl:annotatedTarget "third metacarpal bone epiphysis" . _:genid134342 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003648, obo:UBERON_0014791 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004394 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:86329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004394 ; owl:annotatedTarget "fourth metacarpal bone epiphysis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000837 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004395 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004395 ; owl:annotatedTarget "first metatarsal bone epiphysis" . _:genid134354 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003651, obo:UBERON_0006067 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004396 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004396 ; owl:annotatedTarget "second metatarsal bone epiphysis" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000837 ; owl:annotatedTarget "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004397 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:86313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004397 ; owl:annotatedTarget "third metatarsal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004398 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:86314" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004398 ; owl:annotatedTarget "fourth metatarsal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004399 ; owl:annotatedTarget "An epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:86315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004399 ; owl:annotatedTarget "fifth metatarsal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004400 ; owl:annotatedTarget "A portion of bone tissue that is part of a epiphysis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004401 ; owl:annotatedTarget "A portion of bone tissue that is part of a distal epiphysis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004402 ; owl:annotatedTarget "A portion of bone tissue that is part of a proximal epiphysis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004403 ; owl:annotatedTarget "A periosteum that is part of a epiphysis [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:32687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004403 ; owl:annotatedTarget "epiphysis periosteum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "PMID:23217740" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004404 ; owl:annotatedTarget "A distal epiphysis that is part of a humerus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:32826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004404 ; owl:annotatedTarget "distal end of humerus" . [] oboInOwl:hasDbXref "FMA:32826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004404 ; owl:annotatedTarget "lower end of humerus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004405 ; owl:annotatedTarget "A distal epiphysis that is part of a tibia [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004405 ; owl:annotatedTarget "distal end of tibia" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000838 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "FMA:33116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004405 ; owl:annotatedTarget "lower end of tibia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004406 ; owl:annotatedTarget "A distal epiphysis that is part of a femur [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000893" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004406 ; owl:annotatedTarget "Head of the femur that articulates with the tibia and fibula.[AAO]" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004406 ; owl:annotatedTarget "distal femoral epiphysis" . [] oboInOwl:hasDbXref "AAO:0000893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004406 ; owl:annotatedTarget "distal head of femur" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000838 ; owl:annotatedTarget "A progenitor cell restricted to the lymphoid lineage." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004407 ; owl:annotatedTarget "A distal epiphysis that is part of a radius [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33776" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004407 ; owl:annotatedTarget "distal end of radius" . [] oboInOwl:hasDbXref "FMA:33776" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004407 ; owl:annotatedTarget "lower end of radius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004408 ; owl:annotatedTarget "A distal epiphysis that is part of a ulna [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004408 ; owl:annotatedTarget "distal end of ulna" . [] oboInOwl:hasDbXref "FMA:33754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004408 ; owl:annotatedTarget "lower end of ulna" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "A distal epiphysis that is part of a phalanx of manus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:226577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "distal end of phalanx of hand" . [] oboInOwl:hasDbXref "FMA:226577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "distal epiphysis of phalanx of hand" . [] oboInOwl:hasDbXref "FMA:226577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "head of phalanx of finger" . [] oboInOwl:hasDbXref "FMA:226577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "head of phalanx of hand" . [] oboInOwl:hasDbXref "FMA:226577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004409 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004410 ; owl:annotatedTarget "A distal epiphysis that is part of a fibula [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004410 ; owl:annotatedTarget "distal end of fibula" . [] oboInOwl:hasDbXref "FMA:33732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004410 ; owl:annotatedTarget "lower end of fibula" . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "The upper extremity of the humerus (proximal humerus) consists of a large rounded head joined to the body by a constricted portion called the neck, and two eminences, the greater and lesser tubercles." . [] oboInOwl:hasDbXref "FMA:23362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "proximal end of humerus" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "proximal humeral epiphysis" . [] oboInOwl:hasDbXref "FMA:23362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "upper end of humerus" . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "head of the humerus" . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "humeral head" . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "proximal humerus" . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004411 ; owl:annotatedTarget "upper extremity of humerus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004412 ; owl:annotatedTarget "A proximal epiphysis that is part of a femur [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004412 ; owl:annotatedTarget "proximal femoral epiphysis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004412 ; owl:annotatedTarget "capital femoral epiphysis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000839 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004413 ; owl:annotatedTarget "A proximal epiphysis that is part of a radius [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:39780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004413 ; owl:annotatedTarget "proximal end of radius" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004413 ; owl:annotatedTarget "proximal radial epiphysis" . [] oboInOwl:hasDbXref "FMA:39780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004413 ; owl:annotatedTarget "upper end of radius" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000839 ; owl:annotatedTarget "A progenitor cell restricted to the myeloid lineage." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004414 ; owl:annotatedTarget "A proximal epiphysis that is part of a phalanx of manus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:226482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004414 ; owl:annotatedTarget "basal epiphysis of phalanx of finger" . [] oboInOwl:hasDbXref "FMA:226482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004414 ; owl:annotatedTarget "base of phalanx of finger" . [] oboInOwl:hasDbXref "FMA:226482", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004414 ; owl:annotatedTarget "basis phalangis manus" . [] oboInOwl:hasDbXref "FMA:226482" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004414 ; owl:annotatedTarget "proximal epiphysis of phalanx of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004415 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:33817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004415 ; owl:annotatedTarget "base of metatarsal bone" . [] oboInOwl:hasDbXref "FMA:33817", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004415 ; owl:annotatedTarget "basis ossis metatarsi" . [] oboInOwl:hasDbXref "FMA:33817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004415 ; owl:annotatedTarget "proximal end of metatarsal bone" . [] oboInOwl:hasDbXref "FMA:33817" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004415 ; owl:annotatedTarget "upper end of metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone [Automatically generated definition]." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "Reaxys:82131" . [] oboInOwl:hasDbXref "FMA:33795" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "base of metacarpal bone" . [] oboInOwl:hasDbXref "FMA:33795", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "basis ossis metacarpi" . [] oboInOwl:hasDbXref "FMA:33795" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "metacarpal bone base" . [] oboInOwl:hasDbXref "FMA:33795" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "proximal end of metacarpal bone" . [] oboInOwl:hasDbXref "FMA:33795" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004416 ; owl:annotatedTarget "upper end of metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "A proximal epiphysis that is part of a manual digit 1 phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "basal epiphysis of phalanx of thumb" . [] oboInOwl:hasDbXref "FMA:37489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "base of phalanx of first digit of hand" . [] oboInOwl:hasDbXref "FMA:37489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "base of phalanx of thumb" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "proximal epiphysis of phalanx of manual digit I" . [] oboInOwl:hasDbXref "FMA:37489", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004417 ; owl:annotatedTarget "proximal epiphysis of phalanx of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "A proximal epiphysis that is part of a manual digit 2 phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "basal epiphysis of phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "base of phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "base of phalanx of second digit of hand" . [] oboInOwl:hasDbXref "FMA:37498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "base of phalanx of second finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "proximal epiphysis of phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:37498", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004418 ; owl:annotatedTarget "proximal epiphysis of phalanx of index finger" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000842 ; owl:annotatedTarget obo:CL_0000738 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "A proximal epiphysis that is part of a manual digit 3 phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "basal epiphysis of phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "base of phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "base of phalanx of third digit of hand" . [] oboInOwl:hasDbXref "FMA:37510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "base of phalanx of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "proximal epiphysis of phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:37510", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004419 ; owl:annotatedTarget "proximal epiphysis of phalanx of middle finger" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000842 ; owl:annotatedTarget "A leukocyte with a single non-segmented nucleus in the mature form." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "A proximal epiphysis that is part of a manual digit 4 phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "basal epiphysis of phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "base of phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:37522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "base of phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "base of phalanx of ring finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "proximal epiphysis of phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:37522", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004420 ; owl:annotatedTarget "proximal epiphysis of phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "A proximal epiphysis that is part of a manual digit 5 phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "basal epiphysis of phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "basal epiphysis of phalanx of little finger" . [] oboInOwl:hasDbXref "FMA:37534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "base of phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:37534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "base of phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "base of phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "proximal epiphysis of phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:37534", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004421 ; owl:annotatedTarget "proximal epiphysis of phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004422 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42788" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004422 ; owl:annotatedTarget "base of first metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42788" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004422 ; owl:annotatedTarget "first metacarpal bone base" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004423 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004423 ; owl:annotatedTarget "base of second metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004423 ; owl:annotatedTarget "proximal end of second metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004423 ; owl:annotatedTarget "second metacarpal bone base" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004424 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004424 ; owl:annotatedTarget "base of third metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004424 ; owl:annotatedTarget "proximal end of third metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004424 ; owl:annotatedTarget "third metacarpal bone base" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004425 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004425 ; owl:annotatedTarget "base of fourth metacarpal bone" . _:genid134589 oboInOwl:hasDbXref "FMA:42797" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004425 ; owl:annotatedTarget "fourth metacarpal bone base" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002329 . [] oboInOwl:hasDbXref "FMA:42797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004425 ; owl:annotatedTarget "proximal end of fourth metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004426 ; owl:annotatedTarget "A proximal epiphysis that is part of a metacarpal bone of digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004426 ; owl:annotatedTarget "base of fifth metacarpal bone" . [] oboInOwl:hasDbXref "FMA:42800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004426 ; owl:annotatedTarget "fifth metacarpal bone base" . [] oboInOwl:hasDbXref "FMA:42800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004426 ; owl:annotatedTarget "proximal end of fifth metacarpal bone" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-OXOPROLINE" . (obo:UBERON_0004380 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003650 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004427 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004427 ; owl:annotatedTarget "base of first metatarsal bone" . [] oboInOwl:hasDbXref "FMA:42963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004427 ; owl:annotatedTarget "proximal end of first metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004428 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004428 ; owl:annotatedTarget "base of second metatarsal bone" . [] oboInOwl:hasDbXref "FMA:42964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004428 ; owl:annotatedTarget "proximal end of second metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004429 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004429 ; owl:annotatedTarget "base of third metatarsal bone" . [] oboInOwl:hasDbXref "FMA:42965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004429 ; owl:annotatedTarget "proximal end of third metatarsal bone" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004430 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition]." . _:genid134625 oboInOwl:hasDbXref "FMA:42966" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004430 ; owl:annotatedTarget "base of fourth metatarsal bone" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0010075 . [] oboInOwl:hasDbXref "FMA:42966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004430 ; owl:annotatedTarget "proximal end of fourth metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004431 ; owl:annotatedTarget "A proximal epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004431 ; owl:annotatedTarget "base of fifth metatarsal bone" . [] oboInOwl:hasDbXref "FMA:42967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004431 ; owl:annotatedTarget "proximal end of fifth metatarsal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "A proximal epiphysis that is part of a distal phalanx of manual digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "basal epiphysis of distal phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "base of distal phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "base of distal phalanx of second digit of hand" . [] oboInOwl:hasDbXref "FMA:37505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "base of distal phalanx of second finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:37505", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004432 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of index finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "A proximal epiphysis that is part of a distal phalanx of manual digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "base of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "base of distal phalanx of third digit of hand" . [] oboInOwl:hasDbXref "FMA:37517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "base of distal phalanx of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:37517", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004433 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "A proximal epiphysis that is part of a distal phalanx of manual digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "basal epiphysis of distal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "basal epiphysis of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "base of distal phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:37529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "base of distal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "base of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:37529", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004434 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "A proximal epiphysis that is part of a distal phalanx of manual digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "basal epiphysis of distal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "basal epiphysis of distal phalanx of little finger" . [] oboInOwl:hasDbXref "FMA:37541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "base of distal phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:37541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "base of distal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "base of distal phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:37541", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004435 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "A proximal epiphysis that is part of a middle phalanx of manual digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "basal epiphysis of middle phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "base of middle phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "base of middle phalanx of second digit of hand" . [] oboInOwl:hasDbXref "FMA:37502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "base of middle phalanx of second finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:37502", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004436 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of index finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "A proximal epiphysis that is part of a middle phalanx of manual digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "basal epiphysis of middle phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "base of middle phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "base of middle phalanx of third digit of hand" . [] oboInOwl:hasDbXref "FMA:37514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "base of middle phalanx of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of manual digit III" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-Oxoproline" . [] oboInOwl:hasDbXref "FMA:37514", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004437 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "A proximal epiphysis that is part of a middle phalanx of manual digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "basal epiphysis of middle phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "basal epiphysis of middle phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "base of middle phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:37526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "base of middle phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "base of middle phalanx of ring finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:37526", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004438 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "A proximal epiphysis that is part of a middle phalanx of manual digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "basal epiphysis of middle phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "basal epiphysis of middle phalanx of little finger" . [] oboInOwl:hasDbXref "FMA:37538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "base of middle phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:37538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "base of middle phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "base of middle phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:37538", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004439 ; owl:annotatedTarget "proximal epiphysis of middle phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "A proximal epiphysis that is part of a proximal phalanx of manual digit 2 [Automatically generated definition]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000843 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "FMA:37499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "base of proximal phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "base of proximal phalanx of second digit of hand" . [] oboInOwl:hasDbXref "FMA:37499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "base of proximal phalanx of second finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:37499", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004440 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of index finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "A proximal epiphysis that is part of a proximal phalanx of manual digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMCID:PMC2193793", "PMID:20933013", "http://en.wikipedia.org/wiki/Follicular_B_Cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000843 ; owl:annotatedTarget "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." . [] oboInOwl:hasDbXref "FMA:37511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "basal epiphysis of proximal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "base of proximal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "base of proximal phalanx of third digit of hand" . [] oboInOwl:hasDbXref "FMA:37511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "base of proximal phalanx of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:37511", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004441 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "A proximal epiphysis that is part of a proximal phalanx of manual digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "basal epiphysis of proximal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "basal epiphysis of proximal phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "base of proximal phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:37523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "base of proximal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "base of proximal phalanx of ring finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:37523", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004442 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "A proximal epiphysis that is part of a proximal phalanx of manual digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "basal epiphysis of proximal phalanx of little finger" . [] oboInOwl:hasDbXref "FMA:37535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "base of proximal phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:37535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "base of proximal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "base of proximal phalanx of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:37535", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004443 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004444 ; owl:annotatedTarget "A proximal epiphysis that is part of a distal phalanx of manual digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37493" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004444 ; owl:annotatedTarget "base of distal phalanx of thumb" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004444 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of manual digit I" . [] oboInOwl:hasDbXref "FMA:37493", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004444 ; owl:annotatedTarget "proximal epiphysis of distal phalanx of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004445 ; owl:annotatedTarget "A proximal epiphysis that is part of a proximal phalanx of manual digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:37490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004445 ; owl:annotatedTarget "basal epiphysis of proximal phalanx of thumb" . [] oboInOwl:hasDbXref "FMA:37490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004445 ; owl:annotatedTarget "base of proximal phalanx of thumb" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004445 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of manual digit I" . [] oboInOwl:hasDbXref "FMA:37490", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004445 ; owl:annotatedTarget "proximal epiphysis of proximal phalanx of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004446 ; owl:annotatedTarget "An epiphysis that is part of a phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004447 ; owl:annotatedTarget "A proximal epiphysis that is part of a phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-oxoproline" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004448 ; owl:annotatedTarget "A distal epiphysis that is part of a phalanx [Automatically generated definition]." . [] oboInOwl:hasDbXref "Wikipedia:Cerebral_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004449 ; owl:annotatedTarget "One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010493" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004449 ; owl:annotatedTarget "Part of the internal carotid containing many branches supplying blood to the chorioid plexuses of the brain.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010493" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004449 ; owl:annotatedTarget "relationship loss: part_of internal carotid (AAO:0010219)[AAO]" . [] oboInOwl:external_ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004449 ; owl:annotatedTarget "in AAO this is part_of the internal carotid, but in humans the PCA intervenes for some cerebral arteries. Proper comparative review required" . [] oboInOwl:source "ncithesaurus:Cerebral_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004449 ; owl:annotatedTarget "UMLS:C0007770" . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004451 ; owl:annotatedTarget "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra." . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004451 ; owl:annotatedTarget "it's not clear if the XAO class belongs here or below" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000844 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004451 ; owl:annotatedTarget "EMAPA:37722" . [] oboInOwl:hasDbXref "MA:0002869" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004451 ; owl:annotatedTarget "presacral vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget obo:UBERON_0008785 . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:19447676", "PMID:20933013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000844 ; owl:annotatedTarget "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." . [] oboInOwl:hasDbXref "Wikipedia:Wrist", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted]." . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "fore basipodium" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "fore mesopodium" . [] oboInOwl:hasDbXref "FMA:24922", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "regio carpalis" . [] oboInOwl:hasDbXref "MA:0000039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "wrist" . [] oboInOwl:hasDbXref "EMAPA:19122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "carpus of fore-paw" . [] oboInOwl:hasDbXref "Wikipedia:Wrist" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "articulatio radiocarpea" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004452 ; owl:annotatedTarget "carpus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget obo:UBERON_0005451 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget _:genid136057 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "A metapodium region that is part of a manus." . [] oboInOwl:hasDbXref "FMA:24925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "distal segment of hand proper" . [] oboInOwl:hasDbXref "FMA:24925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "metacarpal part of hand" . [] oboInOwl:hasDbXref "FMA:24925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "metacarpal region" . [] oboInOwl:hasDbXref "MA:0000042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "metacarpus" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "forelimb cannon region" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004453 ; owl:annotatedTarget "forelimb equine cannon region" . [] oboInOwl:hasDbXref "Wikipedia:Ankle", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "Mesopodial segment of the pes, including the tarsal skeleton and associated tissues." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "MA has both tarsus (part of foot, has tarsal bone) and ankle (part of hindlimb, has joint, nerve, skin)." . [] oboInOwl:hasDbXref "MA:0000043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "ankle" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "articulatio talocruralis" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "hind basipodium" . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "hind mesopodium" . [] oboInOwl:hasDbXref "Wikipedia:Hock_(anatomy)" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004454 ; owl:annotatedTarget "hock" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004455 ; owl:annotatedTarget "An embryo at the neurula stage." . [] oboInOwl:source "ncithesaurus:Neurula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004455 ; owl:annotatedTarget "UMLS:C1518306" . [] oboInOwl:hasDbXref "BTO:0001766" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004455 ; owl:annotatedTarget "neurula" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004456 ; owl:annotatedTarget "Sum of all sensory systems in an organism." . [] oboInOwl:hasDbXref "FMA:78499" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004456 ; owl:annotatedTarget "sense organ system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "head musculature" . [] oboInOwl:hasDbXref "FMA:71287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "muscle group of head" . [] oboInOwl:hasDbXref "FMA:71287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "muscles of head" . [] oboInOwl:hasDbXref "FMA:71287", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "musculi capitis" . [] oboInOwl:hasDbXref "FMA:71287" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004461 ; owl:annotatedTarget "set of muscles of head" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004462 ; owl:annotatedTarget "Any collection of muscles that is part of a body wall [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004462 ; owl:annotatedTarget "EMAPA:37853" . [] oboInOwl:hasDbXref "FMA:86931" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004462 ; owl:annotatedTarget "body wall musculature" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-oxopyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004463 ; owl:annotatedTarget "Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004463 ; owl:annotatedTarget "muscle group of thigh" . [] oboInOwl:hasDbXref "FMA:50208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004463 ; owl:annotatedTarget "musculature of thigh" . [] oboInOwl:hasDbXref "FMA:50208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004463 ; owl:annotatedTarget "set of muscles of thigh" . [] oboInOwl:hasDbXref "FMA:50208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004463 ; owl:annotatedTarget "thigh musculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "Any collection of muscles that is part of a thorax [Automatically generated definition]." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "BTO and FMA do not mean precisely the same thing here. BTO thorax muscle is a pectoral muscle or diaphragm" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "EMAPA:37260" . [] oboInOwl:hasDbXref "FMA:71293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "muscle group of thorax" . [] oboInOwl:hasDbXref "FMA:71293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "muscles of thorax" . [] oboInOwl:hasDbXref "FMA:71293", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "musculi thoracis" . [] oboInOwl:hasDbXref "FMA:71293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "set of muscles of thorax" . [] oboInOwl:hasDbXref "FMA:71293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004464 ; owl:annotatedTarget "thoracic musculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "Any collection of muscles that is part of a neck [Automatically generated definition]." . [] oboInOwl:hasDbXref "AAO:0000091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "cervical muscles" . [] oboInOwl:hasDbXref "FMA:71290" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "muscle group of neck" . [] oboInOwl:hasDbXref "FMA:71290" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "muscles of neck" . [] oboInOwl:hasDbXref "FMA:71290", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "musculi cervicis" . [] oboInOwl:hasDbXref "FMA:71290", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "musculi colli" . [] oboInOwl:hasDbXref "FMA:71290" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "neck musculature" . [] oboInOwl:hasDbXref "FMA:71290" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004465 ; owl:annotatedTarget "set of muscles of neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004466 ; owl:annotatedTarget "Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition]." . [] oboInOwl:hasDbXref "EHDAA2:0000973" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004466 ; owl:annotatedTarget "leg muscle system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004467 ; owl:annotatedTarget "The collection of muscles that acts on the pharynx." . [] oboInOwl:hasDbXref "TAO:0001307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004467 ; owl:annotatedTarget "pharyngeal musculature" . [] oboInOwl:hasDbXref "FMA:264609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004467 ; owl:annotatedTarget "set of muscles of pharynx" . [] oboInOwl:hasDbXref "FMA:33061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004468 ; owl:annotatedTarget "muscle group of vertebral column" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004469 ; owl:annotatedTarget "Any collection of muscles that is part of a back [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004469 ; owl:annotatedTarget "muscle group of back" . [] oboInOwl:hasDbXref "FMA:71291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004469 ; owl:annotatedTarget "muscles of back" . [] oboInOwl:hasDbXref "FMA:71291", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004469 ; owl:annotatedTarget "musculi dorsi" . [] oboInOwl:hasDbXref "FMA:71291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004469 ; owl:annotatedTarget "set of muscles of back" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "we merge two FMA classes here" . [] oboInOwl:hasDbXref "FMA:50205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "muscle group of pelvic girdle" . [] oboInOwl:hasDbXref "FMA:50248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "muscle group of pelvis" . [] oboInOwl:hasDbXref "EHDAA2:0001429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "pelvic girdle muscle system" . [] oboInOwl:hasDbXref "AAO:0000427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "pelvic girdle muscles" . [] oboInOwl:hasDbXref "FMA:50205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "pelvic girdle musculature" . [] oboInOwl:hasDbXref "FMA:50205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "set of muscles of pelvic girdle" . [] oboInOwl:hasDbXref "FMA:50248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "muscular system of pelvis" . [] oboInOwl:hasDbXref "FMA:50248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004470 ; owl:annotatedTarget "set of muscles of pelvis" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "EMAPA:37857" . [] oboInOwl:hasDbXref "FMA:33519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "muscle group of pectoral girdle" . [] oboInOwl:hasDbXref "AAO:0000423" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "pectoral girdle muscles" . [] oboInOwl:hasDbXref "FMA:33519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "pectoral girdle musculature" . [] oboInOwl:hasDbXref "FMA:33519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004471 ; owl:annotatedTarget "set of muscles of pectoral girdle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "Any collection of muscles that is part of a face." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "entire facial musculature" . [] oboInOwl:hasDbXref "FMA:71288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "facial muscles" . [] oboInOwl:hasDbXref "FMA:71288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "muscle group of face" . [] oboInOwl:hasDbXref "FMA:71288", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "musculi faciei" . [] oboInOwl:hasDbXref "FMA:71288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "set of facial muscles" . [] oboInOwl:hasDbXref "FMA:71288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004473 ; owl:annotatedTarget "set of muscles of face" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004474 ; owl:annotatedTarget "Any collection of muscles that is part of an arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "EHDAA2:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004474 ; owl:annotatedTarget "arm muscle system" . [] oboInOwl:hasDbXref "FMA:50202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004474 ; owl:annotatedTarget "arm musculature" . [] oboInOwl:hasDbXref "FMA:50202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004474 ; owl:annotatedTarget "muscle group of arm" . [] oboInOwl:hasDbXref "FMA:50202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004474 ; owl:annotatedTarget "set of muscles of arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "2-pyrrolidone-5-carboxylic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000845 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004475 ; owl:annotatedTarget "The collection of muscles that form attachments to the hip skeleton." . [] oboInOwl:hasDbXref "FMA:50227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004475 ; owl:annotatedTarget "hip musculature" . [] oboInOwl:hasDbXref "FMA:50227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004475 ; owl:annotatedTarget "muscle group of hip" . [] oboInOwl:hasDbXref "FMA:50227" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004475 ; owl:annotatedTarget "set of muscles of hip" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:10933592", "PMID:20933013", "http://en.wikipedia.org/wiki/Marginal-zone_B_cell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000845 ; owl:annotatedTarget "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004476 ; owl:annotatedTarget "The collection of muscles that form attachments to the shoulder skeleton." . [] oboInOwl:hasDbXref "FMA:50220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004476 ; owl:annotatedTarget "muscle group of shoulder" . [] oboInOwl:hasDbXref "FMA:50220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004476 ; owl:annotatedTarget "set of muscles of shoulder" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "The collection of muscles that are part of the larynx." . [] oboInOwl:hasDbXref "FMA:46616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "laryngeal muscles" . [] oboInOwl:hasDbXref "FMA:46616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "laryngeal muscles set" . [] oboInOwl:hasDbXref "FMA:46616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "muscle group of larynx" . [] oboInOwl:hasDbXref "FMA:46616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "set of laryngeal muscles" . [] oboInOwl:hasDbXref "FMA:264611" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004478 ; owl:annotatedTarget "set of muscles of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004479 ; owl:annotatedTarget "Any collection of muscles that is part of a trunk [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004479 ; owl:annotatedTarget "muscle group of trunk" . [] oboInOwl:hasDbXref "FMA:50187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004479 ; owl:annotatedTarget "set of muscles of trunk" . [] oboInOwl:hasDbXref "FMA:50187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004479 ; owl:annotatedTarget "muscular system of trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004480 ; owl:annotatedTarget "Any collection of muscles that is part of a limb [Automatically generated definition]." . [] oboInOwl:hasDbXref "EHDAA2:0000995" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004480 ; owl:annotatedTarget "limb muscle system" . [] oboInOwl:hasDbXref "FMA:50188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004480 ; owl:annotatedTarget "limb musculature" . [] oboInOwl:hasDbXref "FMA:50188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004480 ; owl:annotatedTarget "muscle group of limb" . [] oboInOwl:hasDbXref "FMA:50188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004480 ; owl:annotatedTarget "set of muscles of limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004481 ; owl:annotatedTarget "Any collection of muscles that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004481 ; owl:annotatedTarget "free upper limb musculature" . [] oboInOwl:hasDbXref "FMA:50396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004481 ; owl:annotatedTarget "muscle group of free upper limb" . [] oboInOwl:hasDbXref "FMA:50396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004481 ; owl:annotatedTarget "musculature of free upper limb" . [] oboInOwl:hasDbXref "FMA:50396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004481 ; owl:annotatedTarget "set of muscles of free upper limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004482 ; owl:annotatedTarget "Any collection of muscles that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004482 ; owl:annotatedTarget "free lower limb musculature" . [] oboInOwl:hasDbXref "FMA:50399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004482 ; owl:annotatedTarget "muscle group of free lower limb" . [] oboInOwl:hasDbXref "PMID:16841163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000847 ; owl:annotatedTarget "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." . [] oboInOwl:hasDbXref "FMA:50399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004482 ; owl:annotatedTarget "musculature of free lower limb" . [] oboInOwl:hasDbXref "FMA:50399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004482 ; owl:annotatedTarget "set of muscles of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004486 ; owl:annotatedTarget "Any collection of muscles that is part of a perineum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71295", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004486 ; owl:annotatedTarget "musculi perinei" . [] oboInOwl:hasDbXref "FMA:71295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004486 ; owl:annotatedTarget "perineal muscles" . [] oboInOwl:hasDbXref "FMA:71295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004486 ; owl:annotatedTarget "perineal muscles set" . [] oboInOwl:hasDbXref "FMA:71295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004486 ; owl:annotatedTarget "set of perineal muscles" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004487 ; owl:annotatedTarget "Any collection of muscles that is part of a lower arm [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:39089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004487 ; owl:annotatedTarget "muscle group of forearm" . [] oboInOwl:hasDbXref "FMA:39089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004487 ; owl:annotatedTarget "musculature of forearm" . [] oboInOwl:hasDbXref "FMA:39089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004487 ; owl:annotatedTarget "set of muscles of forearm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004488 ; owl:annotatedTarget "Any collection of muscles that is part of a foot [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004488 ; owl:annotatedTarget "foot musculature" . [] oboInOwl:hasDbXref "FMA:50214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004488 ; owl:annotatedTarget "muscle group of foot" . [] oboInOwl:hasDbXref "FMA:50214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004488 ; owl:annotatedTarget "musculature of foot" . [] oboInOwl:hasDbXref "FMA:50214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004488 ; owl:annotatedTarget "set of muscles of foot" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004489 ; owl:annotatedTarget "Any collection of muscles that is part of a manus [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:42368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004489 ; owl:annotatedTarget "hand musculature" . [] oboInOwl:hasDbXref "FMA:42368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004489 ; owl:annotatedTarget "muscle group of hand" . [] oboInOwl:hasDbXref "FMA:42368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004489 ; owl:annotatedTarget "musculature of hand" . [] oboInOwl:hasDbXref "FMA:42368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004489 ; owl:annotatedTarget "set of muscles of hand" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-Pyrrolidone-2-carboxylic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging." . [] oboInOwl:hasDbXref "GO:0055009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "atrial cardiac muscle tissue" . [] oboInOwl:hasDbXref "GO:0055009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "atrial heart muscle" . [] oboInOwl:hasDbXref "GO:0055009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "cardiac atrium muscle" . [] oboInOwl:hasDbXref "GO:0055009", "GOC:mtg_heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004490 ; owl:annotatedTarget "atrial myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004491 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004491 ; owl:annotatedTarget "interatrial septum cardiac muscle tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004491 ; owl:annotatedTarget "interatrial septum heart muscle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004491 ; owl:annotatedTarget "interatrial septum muscle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004491 ; owl:annotatedTarget "interatrial septum myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004492 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004492 ; owl:annotatedTarget "cardiac septum cardiac muscle tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004492 ; owl:annotatedTarget "cardiac septum heart muscle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004492 ; owl:annotatedTarget "cardiac septum muscle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004492 ; owl:annotatedTarget "cardiac septum myocardium" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004493 ; owl:annotatedTarget _:genid136345 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004493 ; owl:annotatedTarget "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004495 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004498 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a quadriceps femoris [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004499 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a tibialis anterior [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004500 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a deltoid [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:261732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004500 ; owl:annotatedTarget "skeletal muscle tissue of deltoid muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004502 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a biceps brachii [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:261974" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004502 ; owl:annotatedTarget "skeletal muscle tissue of biceps brachii muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004503 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a digastric [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004504 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a mylohyoid [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004505 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a orbicularis oculi [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004506 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a masseter [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004507 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a temporalis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004508 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a levator palpebrae superioris [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004509 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a trapezius [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:261938" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004509 ; owl:annotatedTarget "skeletal muscle tissue of trapezius muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004510 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "5-oxo-DL-proline" . [] oboInOwl:hasDbXref "FMA:261968" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004510 ; owl:annotatedTarget "skeletal muscle tissue of pectoralis major muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004511 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a rectus abdominis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004515 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004516 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." . _:genid135220 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004518 ; owl:annotatedTarget "A muscle that is attached to a vertebra of the vertebral column." ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "FMA:22594" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004518 ; owl:annotatedTarget "vertebral column muscle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004519 ; owl:annotatedTarget obo:UBERON_0002379 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004519 ; owl:annotatedTarget "Any muscle organ that is part of a anal part of perineum." . [] oboInOwl:hasDbXref "FMA:77304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004519 ; owl:annotatedTarget "anal triangle muscle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget obo:CL_0000576 . (obo:UBERON_0002036 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002367 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004520 ; owl:annotatedTarget "A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition]." . _:genid135234 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002049 _:genid135236 ) ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000925 . _:genid135236 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0001630, obo:UBERON_0004872 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004521 ; owl:annotatedTarget "A vasculature that is part of a muscle organ [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:87123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004521 ; owl:annotatedTarget "muscular organ vasculature" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000860 ; owl:annotatedTarget "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004522 ; owl:annotatedTarget "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." . _:genid135245 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004103 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002397 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0004527 ; owl:annotatedTarget obo:UBERON_0004528 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004527 ; owl:annotatedTarget "The thickened ridge of bone that contains the tooth sockets on the maxilla." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004527 ; owl:annotatedTarget "In humans, the tooth-bearing bones are the maxilla and the mandible. The mineral content of alveolar bone is mostly hydroxyapatite, which is also found in enamel as the main inorganic substance" . [] oboInOwl:hasDbXref "AAO:0000396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004527 ; owl:annotatedTarget "pars dentalis of maxilla" . [] oboInOwl:hasDbXref "FMA:52897", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004527 ; owl:annotatedTarget "processus alveolaris maxillae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004528 ; owl:annotatedTarget "The thickened ridge of bone that contains the tooth sockets on the mandible." . [] oboInOwl:hasDbXref "FMA:52832" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004528 ; owl:annotatedTarget "alveolar process of mandible" . [] oboInOwl:hasDbXref "FMA:52832" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004528 ; owl:annotatedTarget "pars alveolaris (mandibula)" . [] oboInOwl:hasDbXref "FMA:52832" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004528 ; owl:annotatedTarget "alveolar arch of mandible" . _:genid135262 oboInOwl:hasDbXref "Wikipedia:Alveolar_part_of_mandible" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004528 ; owl:annotatedTarget "pars alveolaris mandibulae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005631 . [] oboInOwl:hasDbXref "Wikipedia:Process_(anatomy)", "https://github.com/obophenotype/uberon/issues/39" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "A projection or outgrowth of tissue from a larger body or organ." . _:genid135265 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010278" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, or tissue.[AAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000085 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001834" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000180" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "TAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[VSAO]" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "process" . [] oboInOwl:hasDbXref "FMA:67601", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "processus" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "flange" . [] oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "flanges" . _:genid135272 oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "lamella" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000323 . [] oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "lamellae" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "lamina" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "laminae" . _:genid135276 oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "processes" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "projection" . [] oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "projections" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "ridge" . [] oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "ridges" . [] oboInOwl:hasDbXref "VSAO:0000180" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "shelf" . [] oboInOwl:hasDbXref "VSAO:0000180" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004529 ; owl:annotatedTarget "shelves" . _:genid135287 a owl:Restriction ; owl:onProperty obo:RO_0002150, obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0003081, obo:UBERON_0004765 . [] oboInOwl:hasDbXref "VSAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004530 ; owl:annotatedTarget "Anatomical projection that is composed of bone tissue." . [] oboInOwl:hasDbXref "FMA:75433" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004530 ; owl:annotatedTarget "bone process" . [] oboInOwl:hasDbXref "ZFA:0001637" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004530 ; owl:annotatedTarget "bony projections" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004533 ; owl:annotatedTarget "A testis that is in the left side of the genitalia [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004533 ; owl:annotatedTarget "EMAPA:37370" . [] oboInOwl:source "ncithesaurus:Left_Testis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004533 ; owl:annotatedTarget "UMLS:C0227998" . [] oboInOwl:hasDbXref "MA:0001746" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004533 ; owl:annotatedTarget "left testicle" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "Glp" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004534 ; owl:annotatedTarget "A testis that is in the right side of the genitalia [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004534 ; owl:annotatedTarget "EMAPA:37371" . [] oboInOwl:source "ncithesaurus:Right_Testis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004534 ; owl:annotatedTarget "UMLS:C0227997" . [] oboInOwl:hasDbXref "MA:0001747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004534 ; owl:annotatedTarget "right testicle" . [] oboInOwl:hasDbXref "BTO:0000088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004535 ; owl:annotatedTarget "Anatomical system that has as its parts the heart and blood vessels." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000302" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.451", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004535 ; owl:annotatedTarget "The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cardiovascular_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004535 ; owl:annotatedTarget "UMLS:C0007226" . [] oboInOwl:hasDbXref "BTO:0000088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004535 ; owl:annotatedTarget "CV system" . [] oboInOwl:hasDbXref "BTO:0000088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004535 ; owl:annotatedTarget "Herz und Gefaesssystem" . [] oboInOwl:hasDbXref "ZFA:0005105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005105" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" . [] oboInOwl:hasDbXref "FMA:63815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "lymphatic trunks and ducts" . [] oboInOwl:hasDbXref "FMA:63815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "lymphatic vessels set" . [] oboInOwl:hasDbXref "FMA:63815", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "trunci et ductus lymphatici" . [] oboInOwl:hasDbXref "ZFA:0005105" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004536 ; owl:annotatedTarget "lymph vessels" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004537 ; owl:annotatedTarget "A vascular network consisting of blood vessels." . [] oboInOwl:hasDbXref "TAO:0001079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004537 ; owl:annotatedTarget "blood vessels" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004538 ; owl:annotatedTarget "A kidney that is part of a left side of organism [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Left_Kidney" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004538 ; owl:annotatedTarget "UMLS:C0227614" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004539 ; owl:annotatedTarget "A kidney that is part of a right side of organism [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Right_Kidney" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004539 ; owl:annotatedTarget "UMLS:C0227613" . _:genid135352 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301, obo:UBERON_0007303 . _:genid135354 a owl:Restriction ; owl:onProperty obo:RO_0002254, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001301, obo:UBERON_0002342 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0004933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004544 ; owl:annotatedTarget "The layer of secretory cells which lines the epididymis." . [] oboInOwl:hasDbXref "FMA:19153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004544 ; owl:annotatedTarget "epididymis epithelium" . [] oboInOwl:hasDbXref "FMA:19153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004544 ; owl:annotatedTarget "epithelium of epididymis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000861 ; owl:annotatedTarget obo:CL_0000235 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004548 ; owl:annotatedTarget "An eye that is part of a left side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004548 ; owl:annotatedTarget "EMAPA:37362" . [] oboInOwl:hasDbXref "FMA:12515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004548 ; owl:annotatedTarget "left eyeball" . [] oboInOwl:hasDbXref "FMA:54450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004548 ; owl:annotatedTarget "left orbital part of face" . [] oboInOwl:hasDbXref "FMA:54450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004548 ; owl:annotatedTarget "left orbital region" . [] oboInOwl:hasDbXref "GOC:add", "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:15771589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000861 ; owl:annotatedTarget "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004549 ; owl:annotatedTarget "An eye that is part of a right side of organism [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004549 ; owl:annotatedTarget "EMAPA:37363" . [] oboInOwl:hasDbXref "FMA:12514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004549 ; owl:annotatedTarget "right eyeball" . [] oboInOwl:hasDbXref "FMA:54449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004549 ; owl:annotatedTarget "right orbital part of face" . [] oboInOwl:hasDbXref "FMA:54449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004549 ; owl:annotatedTarget "right orbital region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004552 ; owl:annotatedTarget "An artery that is part of a digit [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004552 ; owl:annotatedTarget "EMAPA:37076" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004553 ; owl:annotatedTarget _:genid136602 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004553 ; owl:annotatedTarget "A digital artery that is part of a forelimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004553 ; owl:annotatedTarget "EMAPA:37210" . [] oboInOwl:hasDbXref "MA:0001953" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004553 ; owl:annotatedTarget "forelimb digital arteries" . _:genid135390 oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004553 ; owl:annotatedTarget "wing digital artery" ; owl:onProperty obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0001985 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004554 ; owl:annotatedTarget "A digital artery that is part of a hindlimb [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004554 ; owl:annotatedTarget "EMAPA:37214" . [] oboInOwl:hasDbXref "FMA:69713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004554 ; owl:annotatedTarget "digital artery of foot" . [] oboInOwl:hasDbXref "MA:0001964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004554 ; owl:annotatedTarget "hindlimb digital arteries" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "Pyroglutamate" . [] oboInOwl:source "MA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004571 ; owl:annotatedTarget obo:UBERON_0007798 . [] oboInOwl:hasDbXref "Wikipedia:Systemic_circulation#Arteries", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004571 ; owl:annotatedTarget "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." . _:genid135402 oboInOwl:hasDbXref "FMA:45623" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004571 ; owl:annotatedTarget "systemic arterial circulatory system" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001557 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004572 ; owl:annotatedTarget obo:UBERON_0007798 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004572 ; owl:annotatedTarget _:genid136621 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004572 ; owl:annotatedTarget "The part of the cardiovascular system consisting of all arteries." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000273" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004572 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Artery#Systemic_arteries", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004573 ; owl:annotatedTarget "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004573 ; owl:annotatedTarget "EMAPA:37126" . [] oboInOwl:hasDbXref "FMA:66464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004573 ; owl:annotatedTarget "systemic arterial subtree" . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Systemic_venous_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004581 ; owl:annotatedTarget "The part of the venous system that drains the general body tissues[Kardong]." . [] oboInOwl:source "Wikipedia:Systemic_venous_system" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004581 ; owl:annotatedTarget "In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP]" . [] oboInOwl:ontology "FMA" ; oboInOwl:source "FMA:45626" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004581 ; owl:annotatedTarget "Subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava[FMA]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000277" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004581 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000862 ; owl:annotatedTarget obo:CL_0000861 . [] oboInOwl:hasDbXref "FMA:45626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004581 ; owl:annotatedTarget "systemic venous circulatory system" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004582 ; owl:annotatedTarget obo:UBERON_0007798 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004582 ; owl:annotatedTarget "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000277" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004582 ; owl:annotatedTarget "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Venous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004582 ; owl:annotatedTarget "UMLS:C1267406" . [] oboInOwl:hasDbXref "Wikipedia:Sphincter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004590 ; owl:annotatedTarget "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004590 ; owl:annotatedTarget "FMA class is not a subtype of muscle" . [] oboInOwl:source "ncithesaurus:Sphincter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004590 ; owl:annotatedTarget "UMLS:C1409894" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "The first rib of the rib cage." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "PMID:20402419" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000862 ; owl:annotatedTarget "A macrophage that suppresses immune responses." . [] oboInOwl:source "ncithesaurus:Rib_1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "UMLS:C1709945" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "costa I" . [] oboInOwl:hasDbXref "FMA:7597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "costa prima (I)" . [] oboInOwl:hasDbXref "FMA:7597", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "costa prima [I]" . [] oboInOwl:hasDbXref "FMA:7597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "first rib" . [] oboInOwl:hasDbXref "Wikipedia:First_rib" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004601 ; owl:annotatedTarget "costa prima" . [] oboInOwl:hasDbXref "Wikipedia:Twelfth_rib" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004611 ; owl:annotatedTarget "In humans: The twelfth rib has a single articular facet on the head, which is of rather large size. It has no necks or tubercles, and is pointed at its anterior ends. The twelfth has angle nor costal groove; it is much shorter than the eleventh rib, and its head is inclined slightly downward. Sometimes the twelfth rib is even shorter than the first rib. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Rib_12" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004611 ; owl:annotatedTarget "UMLS:C1709948" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004611 ; owl:annotatedTarget "costa XII" . [] oboInOwl:hasDbXref "FMA:8515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004611 ; owl:annotatedTarget "twelfth rib" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget _:genid136658 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:C3_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "The third of the seven cervical vertebrae[ncit,modified]." . [] oboInOwl:source "ncithesaurus:C3_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "UMLS:C0459939" . [] oboInOwl:hasDbXref "FMA:12521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "C3 vertebra" . [] oboInOwl:hasDbXref "MA:0001423" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "cervical vertebra 3" . [] oboInOwl:hasDbXref "UBERONTEMP:aeb6ac70-fd18-403d-a0b9-dd03942c7812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "cervical vertebrae 3" . [] oboInOwl:hasDbXref "FMA:12521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "third cervical vertebra" . [] oboInOwl:hasDbXref "UBERONTEMP:aeb6ac70-fd18-403d-a0b9-dd03942c7812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004612 ; owl:annotatedTarget "third cervical vertebra of axial skeleton" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget _:genid136667 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:C4_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget "The fourth of the seven cervical vertebrae[ncit,modified]." . [] oboInOwl:source "ncithesaurus:C4_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget "UMLS:C0459941" . [] oboInOwl:hasDbXref "FMA:12522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget "C4 vertebra" . [] oboInOwl:hasDbXref "MA:0001424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget "cervical vertebra 4" . [] oboInOwl:hasDbXref "FMA:12522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004613 ; owl:annotatedTarget "fourth cervical vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget _:genid136674 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:C5_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget "The fifth of the seven cervical vertebrae[ncit,modified]." . [] oboInOwl:source "ncithesaurus:C5_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget "UMLS:C0459943" . [] oboInOwl:hasDbXref "FMA:12523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget "C5 vertebra" . [] oboInOwl:hasDbXref "MA:0001425" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget "cervical vertebra 5" . [] oboInOwl:hasDbXref "FMA:12523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004614 ; owl:annotatedTarget "fifth cervical vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget _:genid136681 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:C6_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget "The sixth of the seven cervical vertebrae[ncit,modified]." . [] oboInOwl:source "ncithesaurus:C6_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget "UMLS:C0459944" . [] oboInOwl:hasDbXref "FMA:12524" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget "C6 vertebra" . [] oboInOwl:hasDbXref "MA:0001426" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget "cervical vertebra 6" . [] oboInOwl:hasDbXref "FMA:12524" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004615 ; owl:annotatedTarget "sixth cervical vertebra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:L1_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004617 ; owl:annotatedTarget "The first lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." . [] oboInOwl:source "ncithesaurus:L1_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004617 ; owl:annotatedTarget "UMLS:C0223492" . [] oboInOwl:hasDbXref "FMA:13072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004617 ; owl:annotatedTarget "L1 vertebra" . [] oboInOwl:hasDbXref "FMA:13072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004617 ; owl:annotatedTarget "first lumbar vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004618 ; owl:annotatedTarget _:genid136692 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:L2_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004618 ; owl:annotatedTarget "The second lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." . [] oboInOwl:source "ncithesaurus:L2_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004618 ; owl:annotatedTarget "UMLS:C0223507" . [] oboInOwl:hasDbXref "FMA:13073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004618 ; owl:annotatedTarget "L2 vertebra" . [] oboInOwl:hasDbXref "FMA:13073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004618 ; owl:annotatedTarget "second lumbar vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004619 ; owl:annotatedTarget _:genid136698 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:L3_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004619 ; owl:annotatedTarget "The third lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." . [] oboInOwl:source "ncithesaurus:L3_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004619 ; owl:annotatedTarget "UMLS:C0223522" . [] oboInOwl:hasDbXref "FMA:13074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004619 ; owl:annotatedTarget "L3 vertebra" . [] oboInOwl:hasDbXref "FMA:13074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004619 ; owl:annotatedTarget "third lumbar vertebra" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000864 ; owl:annotatedTarget obo:CL_0000235 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004620 ; owl:annotatedTarget _:genid136704 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:L4_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004620 ; owl:annotatedTarget "The fourth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." . [] oboInOwl:source "ncithesaurus:L4_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004620 ; owl:annotatedTarget "UMLS:C0223537" . [] oboInOwl:hasDbXref "FMA:13075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004620 ; owl:annotatedTarget "L4 vertebra" . [] oboInOwl:hasDbXref "FMA:13075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004620 ; owl:annotatedTarget "fourth lumbar vertebra" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004621 ; owl:annotatedTarget _:genid136710 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:L5_Vertebra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004621 ; owl:annotatedTarget "The fifth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified]." . [] oboInOwl:source "ncithesaurus:L5_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004621 ; owl:annotatedTarget "UMLS:C0223552" . [] oboInOwl:hasDbXref "FMA:13076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004621 ; owl:annotatedTarget "L5 vertebra" . [] oboInOwl:hasDbXref "FMA:13076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004621 ; owl:annotatedTarget "fifth lumbar vertebra" . [] oboInOwl:hasDbXref "GOC:ana", "GO_REF:0000031", "PMID:19770654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000864 ; owl:annotatedTarget "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." . [] oboInOwl:source "ncithesaurus:S1_Vertebra" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004622 ; owl:annotatedTarget "UMLS:C0223598" . [] oboInOwl:hasDbXref "FMA:13077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004622 ; owl:annotatedTarget "S1 vertebra" . [] oboInOwl:hasDbXref "FMA:13077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004622 ; owl:annotatedTarget "first sacral segment" . [] oboInOwl:hasDbXref "FMA:13077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004622 ; owl:annotatedTarget "first sacral vertebra" . [] oboInOwl:hasDbXref "FMA:13077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004622 ; owl:annotatedTarget "first segment of sacrum" . [] oboInOwl:hasDbXref "http://www.biology-online.org/dictionary/Otic_capsule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "The capsule surrounding the inner ear mechanism." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010143" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "Skeletal elements surrounding the membranous labyrinth of the inner ear. Sensory capsules anterolateral to and confluent with occipital arch.[AAO]" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16010 ; owl:annotatedTarget "Pyroglutamic acid" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000854" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "The cartilage capsule surrounding the inner ear mechanism; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony. [Biology_online][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010143" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "relationship loss: part_of occipito-petrosal (AAO:0010831)[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010143" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "relationship loss: part_of otic and occipital (AAO:0000993)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000854" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.235, DOI:10.1016/S0378-5955(00)00168-4 Fay RR, Popper AN, Evolution of hearing in vertebrates: the inner ears and processing. Hearing research (2000)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "Otic capsules develop around the parts of the ear that lie within the chondrocranium. This part of the ear, known as the inner ear, is composed of the semicircular ducts and associated sacs that contain the receptive cells for equilibrium and hearing (reference 1); (...) considerations have led to our rethinking issues related to the origin of several aspects of vertebrate hearing, and to the view that many basic auditory functions evolved very early in vertebrate history, and that the functions observed in more `advanced' vertebrates, such as birds and mammals, are frequently modifications of themes first encountered in fishes, and perhaps even more ancestral animals.[well established][VHOG]" . [] oboInOwl:source "Biology-Online" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "in elasmobranchs, it remains cartilaginous in the adult; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony (at approximately 23 weeks in humans)" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "otic capsule skeletal element" . [] oboInOwl:hasDbXref "ZFA:0001500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "otic capsule" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "otic capsule element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "otic capsule endochondral element" . [] oboInOwl:hasDbXref "VHOG:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "auditory capsule" . [] oboInOwl:hasDbXref "VHOG:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004637 ; owl:annotatedTarget "periotic capsule" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004638 ; owl:annotatedTarget "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart." . [] oboInOwl:source "ncithesaurus:Blood_Vessel_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004638 ; owl:annotatedTarget "UMLS:C1706972" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget _:genid136745 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0011312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism." . [] oboInOwl:hasDbXref "MA:0002579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "afferent arteriole" . [] oboInOwl:hasDbXref "ZFA:0005307" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "afferent glomerular arteriole" . [] oboInOwl:hasDbXref "FMA:77042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "afferent glomerular arteriole of kidney" . [] oboInOwl:hasDbXref "FMA:77042", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "arteriola glomerularis afferens renis" . [] oboInOwl:hasDbXref "MP:0011312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "kidney afferent arteriole" . [] oboInOwl:hasDbXref "Wikipedia:Afferent_arterioles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004639 ; owl:annotatedTarget "arteriola glomerularis afferens" . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002227" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "The connective tissue that surrounds the spleen." . [] oboInOwl:source "ncithesaurus:Splenic_Capsule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "UMLS:C0229681" . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "Malpighian capsule" . [] oboInOwl:hasDbXref "FMA:15849", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "capsula splenica" . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "capsule of spleen" . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "fibroelastic coat of spleen" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget obo:CL_0000864 . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "fibrous capsule of spleen" . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "splenic capsule" . [] oboInOwl:hasDbXref "FMA:15849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "tunica fibrosa (splen)(lien)" . [] oboInOwl:hasDbXref "FMA:15849", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004641 ; owl:annotatedTarget "tunica fibrosa splenica" . [] oboInOwl:hasDbXref "Wikipedia:Infraorbital_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004646 ; owl:annotatedTarget "The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004646 ; owl:annotatedTarget "EMAPA:37090" . [] oboInOwl:source "ncithesaurus:Infraorbital_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004646 ; owl:annotatedTarget "UMLS:C0226153" . [] oboInOwl:hasDbXref "FMA:49767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004646 ; owl:annotatedTarget "infra-orbital artery" . [] oboInOwl:hasDbXref "Wikipedia:Infraorbital_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004646 ; owl:annotatedTarget "a. infraorbitalis" . [] oboInOwl:hasDbXref "GO_REF:0000031", "PMID:16322748" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000878 ; owl:annotatedTarget "A tissue-resident macrophage found in the central nervous system." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget obo:UBERON_0000064 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget _:genid136778 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0008987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." . [] oboInOwl:source "ncithesaurus:Hepatic_Lobule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "UMLS:C0227518" . [] oboInOwl:hasDbXref "FMA:14471" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "hepatic lobule" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "lobuli hepatici" . [] oboInOwl:hasDbXref "FMA:14471" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "lobulus hepaticus" . [] oboInOwl:hasDbXref "Wikipedia:Lobules_of_liver" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "lobules of liver" . [] oboInOwl:hasDbXref "Wikipedia:Lobules_of_liver" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004647 ; owl:annotatedTarget "lobuli hepatis" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget _:genid136790 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0004452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "The process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010086" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "Process that projects from posterior margin of commissure into subocular space.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010086" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "relationship loss: part_of anterior quadratocranial commissure (AAO:0010061)[AAO]" . [] oboInOwl:hasDbXref "FMA:54682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "processus pterygoideus" . [] oboInOwl:hasDbXref "FMA:54682", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "processus pterygoideus ossis sphenoidalis" . [] oboInOwl:hasDbXref "FMA:54682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid process" . [] oboInOwl:hasDbXref "FMA:54682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid process of sphenoid" . [] oboInOwl:hasDbXref "FMA:54682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid process of sphenoid bone" . [] oboInOwl:hasDbXref "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "processus pterygoideus ossis sphenoidalis" . [] oboInOwl:hasDbXref "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid plate" . [] oboInOwl:hasDbXref "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid process" . [] oboInOwl:hasDbXref "MA:0002774" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid process of sphenoid bone" . [] oboInOwl:hasDbXref "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid processes" . [] oboInOwl:hasDbXref "Wikipedia:Pterygoid_processes_of_the_sphenoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004649 ; owl:annotatedTarget "pterygoid processus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004650 ; owl:annotatedTarget "A keratinized stratified squamous epithelium that is part of a tongue." . [] oboInOwl:hasDbXref "FMA:74865" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004650 ; owl:annotatedTarget "keratinized epithelium of tongue" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_humerus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "The body or shaft of the humerus is almost cylindrical in the upper half of its extent, prismatic and flattened below, and has three borders and three surfaces." . [] oboInOwl:hasDbXref "FMA:13305" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "body of humerus" . [] oboInOwl:hasDbXref "FMA:13305", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "corpus humeri" . [] oboInOwl:hasDbXref "FMA:13305" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "diaphysis of humerus" . [] oboInOwl:hasDbXref "FMA:13305" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "humeral diaphysis" . [] oboInOwl:hasDbXref "FMA:13305" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "shaft of humerus" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "body of the humerus" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "medial humerus" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004652 ; owl:annotatedTarget "shaft of the humerus" . [] oboInOwl:hasDbXref "MFMO:0000056" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "Articular part of the mandible bone." . [] oboInOwl:hasDbXref "FMA:52836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "condylar process of mandible" . [] oboInOwl:hasDbXref "MFMO:0000056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "condyle of the mandible" . [] oboInOwl:hasDbXref "BTO:0001750" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "mandibular condyle" . [] oboInOwl:hasDbXref "FMA:52836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "processus condylaris" . [] oboInOwl:hasDbXref "FMA:52836", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "processus condylaris mandibulae" . [] oboInOwl:hasDbXref "Wikipedia:Condyloid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "condyle of mandible" . [] oboInOwl:hasDbXref "Wikipedia:Condyloid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "condyle of the mandible" . [] oboInOwl:hasDbXref "Wikipedia:Condyloid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "condyloid process" . [] oboInOwl:hasDbXref "MA:0002816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004657 ; owl:annotatedTarget "mandibular condyloid process" . [] oboInOwl:hasDbXref "Wikipedia:Coronoid_process_of_the_mandible", "http://palaeos.com/vertebrates/glossary/glossaryCh.html#Coronoid%20process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "A dorsal process on the lower jaw associated with muscle attachment. It may be formed by a separate coronoid bone or as a process of the dentary. In most living (and many extinct) mammals, the most dorsal of the three proximal processes of the jaw." . [] oboInOwl:external_ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "TAO:0001673 coronoid process, a bony projection on dentary" . [] oboInOwl:hasDbXref "AAO:0000103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "coronoid" . [] oboInOwl:hasDbXref "FMA:52833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "coronoid process of mandible" . [] oboInOwl:hasDbXref "FMA:52833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "processus coronoideus (mandibula)" . [] oboInOwl:hasDbXref "MA:0002819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "mandibular coronoid process" . [] oboInOwl:hasDbXref "Wikipedia:Coronoid_process_of_the_mandible" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004660 ; owl:annotatedTarget "processus coronoideus mandibulae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004663 ; owl:annotatedTarget "An anatomical wall that is part of an aorta, enclosing the luminal space." . [] oboInOwl:hasDbXref "FMA:14156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004663 ; owl:annotatedTarget "aortic wall" . [] oboInOwl:hasDbXref "FMA:14156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004663 ; owl:annotatedTarget "wall of aorta" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0009871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004664 ; owl:annotatedTarget "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers." . [] oboInOwl:hasDbXref "FMA:14283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004664 ; owl:annotatedTarget "tunica adventitia of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "A muscular coat that is part of a seminal vesicle [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:19404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "muscle layer of seminal vesicle" . [] oboInOwl:hasDbXref "FMA:19404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "muscular coat of seminal gland" . [] oboInOwl:hasDbXref "FMA:19404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "muscular layer of seminal gland" . [] oboInOwl:hasDbXref "FMA:19404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "tunica muscularis (vesicula seminalis)" . [] oboInOwl:hasDbXref "FMA:19404", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004665 ; owl:annotatedTarget "tunica muscularis glandulae vesiculosae" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget _:genid136879 . [] oboInOwl:hasDbXref "MP:0008823" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "The membranous portion of the wall between the two lower chambers of the heart." . [] oboInOwl:source "GO:0003149" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "The membranous septum is the upper part of ventricular septum[GO:0003149]." . [] oboInOwl:hasDbXref "GO:0003149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous septum" . [] oboInOwl:hasDbXref "VT:0000018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "ventricle membranous septum" . [] oboInOwl:hasDbXref "MP:0008823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "ventricular membranous septum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "cardiac ventricular membranous septum" . [] oboInOwl:hasDbXref "FMA:7135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous interventricular septum" . [] oboInOwl:hasDbXref "VHOG:0000927" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous part interventricular septum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000881 ; owl:annotatedTarget obo:CL_0000878 . [] oboInOwl:hasDbXref "FMA:7135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous part of interventricular septum" . [] oboInOwl:hasDbXref "FMA:7135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous portion of interventricular septum" . [] oboInOwl:hasDbXref "FMA:7135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "pars membranacea (septi interventricularis)" . [] oboInOwl:hasDbXref "FMA:7135", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "pars membranacea septi interventricularis" . [] oboInOwl:hasDbXref "MA:0002939" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004666 ; owl:annotatedTarget "membranous interventricular septum" . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000031", "PMID:16507898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000881 ; owl:annotatedTarget "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." . [] oboInOwl:hasDbXref "Wikipedia:Interventricular_septum#Portions", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "The muscular portion of the wall between the two lower chambers of the heart." . [] oboInOwl:source "GO:0003150" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "The muscular septum is the lower part of the ventricular septum[GO]" . [] oboInOwl:hasDbXref "GO:0003150" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "muscular septum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "cardiac ventricular muscular septum" . [] oboInOwl:hasDbXref "FMA:7134" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "muscular interventricular septum" . [] oboInOwl:hasDbXref "FMA:7134" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "muscular part of interventricular septum" . [] oboInOwl:hasDbXref "FMA:7134" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "pars muscularis (septi interventricularis)" . [] oboInOwl:hasDbXref "FMA:7134", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "pars muscularis septi interventricularis" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "septum membranaceum" . [] oboInOwl:hasDbXref "MA:0002940" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004667 ; owl:annotatedTarget "muscular interventricular septum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004668 ; owl:annotatedTarget "One of: the 4th ventricle median or lateral apertures." . [] oboInOwl:hasDbXref "FMA:242766" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004668 ; owl:annotatedTarget "aperture of fourth ventricle" . [] oboInOwl:hasDbXref "NLXANAT:090819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "The sensory system for the sense of balance." . [] oboInOwl:source "Wikipedia:Vestibular_system" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "The vestibular system, which contributes to our balance and our sense of spatial orientation, is the sensory system that provides the dominant input about movement and equilibrioception. Together with the cochlea, a part of the auditory system, it constitutes the labyrinth of the inner ear, situated in the vestibulum in the inner ear. As our movements consist of rotations and translations, the vestibular system comprises two components: the semicircular canal system, which indicate rotational movements; and the otoliths, which indicate linear accelerations. The vestibular system sends signals primarily to the neural structures that control our eye movements, and to the muscles that keep us upright. The projections to the former provide the anatomical basis of the vestibulo-ocular reflex, which is required for clear vision; and the projections to the muscles that control our posture are necessary to keep us upright[Wikipedia:Vestibular_system]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "FMA and NIF have no part information for this class. This is a GAT in FMA" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "EMAPA:37986" . [] oboInOwl:hasDbXref "FMA:7193" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "vestibular organ system" . [] oboInOwl:hasDbXref "NLXANAT:090819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004681 ; owl:annotatedTarget "vestibular system" . [] oboInOwl:source "GO", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget _:genid136928 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget _:genid136930 . [] oboInOwl:hasDbXref "NLXANAT:20090205", "https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." . [] oboInOwl:source "ncithesaurus:Raphe_Nuclei" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "UMLS:C0034671" . [] oboInOwl:hasDbXref "FMA:84017", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "nuclei raphes" . [] oboInOwl:hasDbXref "FMA:84017", "NLXANAT:20090205" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "raphe nuclei" . [] oboInOwl:hasDbXref "FMA:84017" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "raphe nuclei set" . [] oboInOwl:hasDbXref "Wikipedia:Raphe_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "nuclei raphes" . [] oboInOwl:hasDbXref "Wikipedia:Raphe_nuclei" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "raphe cluster" . [] oboInOwl:hasDbXref "ZFA:0001429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "raphe nucleus" . [] oboInOwl:hasDbXref "BAMS:RA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "raphe of mesenchephalon" . [] oboInOwl:hasDbXref "FMA:84017" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004684 ; owl:annotatedTarget "set of raphe nuclei" . [] oboInOwl:hasDbXref "Wikipedia:Costocervical_trunk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004688 ; owl:annotatedTarget "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004688 ; owl:annotatedTarget "EMAPA:37496" . [] oboInOwl:hasDbXref "FMA:10636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004688 ; owl:annotatedTarget "costocervical trunk" . [] oboInOwl:hasDbXref "FMA:10636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004688 ; owl:annotatedTarget "trunk of costocervical artery" . [] oboInOwl:hasDbXref "Wikipedia:Costocervical_trunk" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004688 ; owl:annotatedTarget "truncus costocervicalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004692 ; owl:annotatedTarget "An epithelium that is part of an external naris [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004695 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004696 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004698 ; owl:annotatedTarget "An endothelium that is part of a vena cava [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004698 ; owl:annotatedTarget "EMAPA:37800" . [] oboInOwl:source "ncithesaurus:Vena_Cava_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004698 ; owl:annotatedTarget "UMLS:C1710623" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004699 ; owl:annotatedTarget "An endothelium that is part of a outflow tract [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001524" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1254/jjp.87.253 Shigei T, Tsuru H, Ishikawa N, Yoshioka K, Absence of endothelium in invertebrate blood vessels: significance of endothelium and sympathetic nerve/medial smooth muscle in the vertebrate vascular system. Japanese Journal of Pharmacology (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004699 ; owl:annotatedTarget "It is assumed that during evolution, a circulatory system composed of the heart and endothelial tubular system first formed in vertebrates, medial smooth muscle then appeared for regulation of the system, and innervation of the muscle tissue took place. This sequence of development assumed for phylogenesis is actually realized in the ontogenetic processes.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004700 ; owl:annotatedTarget "An endothelium that is part of an arterial system [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Arterial_System_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004700 ; owl:annotatedTarget "UMLS:C1706849" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004701 ; owl:annotatedTarget "An endothelium that is part of a venous system [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Venous_System_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004701 ; owl:annotatedTarget "UMLS:C1710626" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004702 ; owl:annotatedTarget "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:62007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "dorsal thalamus" . [] oboInOwl:hasDbXref "FMA:62007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "dorsal thalamus (Anthoney)" . [] oboInOwl:hasDbXref "BTO:0001365", "Wikipedia:Thalamus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "thalamus dorsalis" . [] oboInOwl:hasDbXref "PMCID:PMC3345571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "thalamus proper" . [] oboInOwl:hasDbXref "ZFA:0000653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "thalamus, pars dorsalis" . [] oboInOwl:hasDbXref "DMBA:DTTh" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004703 ; owl:annotatedTarget "dorsal tier of thalamus" . [] oboInOwl:source "FMA-implied" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget obo:UBERON_0002553 . [] oboInOwl:hasDbXref "Wikipedia:Fossa#Anatomy" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "A depression or hollow in a bone[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001743" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "Anatomical space that is a concavity, shallow depression, or groove on a bone.[TAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "General Anatomical term in FMA; not restricted to bone in ncit; surface feature in VSAO; note that entities named 'fossa' are cavities in FMA, hence placement here" . [] oboInOwl:source "ncithesaurus:Fossa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "UMLS:C0836913" . [] oboInOwl:hasDbXref "TAO:0001743" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "concavities" . [] oboInOwl:hasDbXref "TAO:0001743" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "concavity" . [] oboInOwl:hasDbXref "TAO:0001743" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "depression" . [] oboInOwl:hasDbXref "TAO:0001743" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "depressions" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000889 ; owl:annotatedTarget obo:CL_0000766 . [] oboInOwl:hasDbXref "TAO:0001743" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "fossae" . [] oboInOwl:hasDbXref "TAO:0001743" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004704 ; owl:annotatedTarget "groove" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004706 ; owl:annotatedTarget "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000173" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004706 ; owl:annotatedTarget "A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO]" . [] oboInOwl:source "ncithesaurus:Bulbus_Cordis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004706 ; owl:annotatedTarget "UMLS:C1284055" . [] oboInOwl:hasDbXref "EHDAA2:0000197" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004706 ; owl:annotatedTarget "primitive right ventricle endocardium" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004707 ; owl:annotatedTarget "A stage that follows the blastula, gastrula and neurula stages. At the pharyngula stage, all vertebrate embryos show remarkable similarities." . [] oboInOwl:hasDbXref "GOC:add", "GOC:ana", "GO_REF:0000031", "PMID:16168663", "PMID:17016554", "PMID:17016559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000889 ; owl:annotatedTarget "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget obo:UBERON_0000026 . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000891 ; owl:annotatedTarget "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget _:genid137027 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget _:genid137033 . [] oboInOwl:hasDbXref "UBERON:cjm", "https://github.com/geneontology/go-ontology/issues/9029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "An appendage that is part of an appendage girdle complex." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "girdle-associated appendage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "limb or fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "limb/fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "pectoral or pelvic appendage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "pelvic/pectoral appendage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "jointed paired lateral appendage" . [] oboInOwl:hasDbXref "VSAO:0000067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004708 ; owl:annotatedTarget "paired appendage" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget _:genid137049 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget obo:UBERON_0004710 . [] oboInOwl:hasDbXref "VSAO:0000150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget "Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget "hindlimb/pelvic fin" . [] oboInOwl:hasDbXref "VSAO:0000126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget "pelvic appendage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget "pelvic limb/fin" . [] oboInOwl:hasDbXref "VSAO:0000126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004709 ; owl:annotatedTarget "posterior paired appendage" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget _:genid137063 . [] oboInOwl:hasDbXref "VSAO:0000150-modified" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001753" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jmor.10264 Davis MC, Shubin NH, Force A, Pectoral fin and girdle development in the basal actinopterygians Polyodon spathula and Acipenser transmontanus. Journal of Morphology (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "anterior limb/fin" . [] oboInOwl:hasDbXref "VSAO:0000148" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "anterior paired appendage" . [] oboInOwl:hasDbXref "VHOG:0001753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "forelimb - pectoral fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "forelimb or pectoral fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "forelimb/pectoral fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004710 ; owl:annotatedTarget "pectoral limb/fin" . [] oboInOwl:hasDbXref "Wikipedia:Jugular_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004711 ; owl:annotatedTarget "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava." . [] oboInOwl:source "ncithesaurus:Jugular_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004711 ; owl:annotatedTarget "UMLS:C0022427" . [] oboInOwl:hasDbXref "BTO:0001744" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004711 ; owl:annotatedTarget "vena jugularis" . [] oboInOwl:hasDbXref "BTO:0002019", "Wikipedia:Corpus_cavernosum_penis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "One of the columns of erectile tissue forming the dorsum and sides of the penis." . [] oboInOwl:hasDbXref "BTO:0002019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "corpus cavernosum" . [] oboInOwl:hasDbXref "MA:0001743" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "penis erectile tissue" . [] oboInOwl:source "ncithesaurus:Corpora_Cavernosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "UMLS:C0227937" . [] oboInOwl:source "ncithesaurus:Penis_Erectile_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "UMLS:C1709494" . [] oboInOwl:hasDbXref "FMA:19618" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "corpus cavernosum of penis" . [] oboInOwl:hasDbXref "BTO:0002019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "cavernous body of penis" . [] oboInOwl:hasDbXref "Wikipedia:Corpus_cavernosum_penis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "corpus cavernosum penis" . [] oboInOwl:hasDbXref "BTO:0002019" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "corpus spongiosum penis" . [] oboInOwl:hasDbXref "BTO:0002019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "penile corpus cavernosum" . [] oboInOwl:hasDbXref "BTO:0002019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "spongy body of male urethra" . [] oboInOwl:hasDbXref "BTO:0002019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004713 ; owl:annotatedTarget "spongy body of penis" . [] oboInOwl:hasDbXref "BIRNLEX:1315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "A triangular double membrane, consisting of glial cells and fibers (Heimer, 1996) separating the anterior horns of the lateral ventricles of the brain. It is situated in the median plane and bounded by the corpus callosum and the body and columns of the fornix." . [] oboInOwl:source "BIRNLEX:1315", "ncithesaurus:Septum_Pellucidum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "UMLS:C0036700" . [] oboInOwl:source "BIRNLEX:1315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "neuronames:256" . [] oboInOwl:hasDbXref "BIRNLEX:1315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "septal pellucidum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "septum pellucidum of telencephalic ventricle" . [] oboInOwl:hasDbXref "FMA:61844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "supracommissural septum" . [] oboInOwl:hasDbXref "MP:0012004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "lateral septum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000893 ; owl:annotatedTarget obo:CL_0002420 . [] oboInOwl:hasDbXref "BTO:0003448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "pellucidum" . [] oboInOwl:hasDbXref "NeuroNames:256" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "septum gliosum" . [] oboInOwl:hasDbXref "BTO:0003448", "MP:0012004" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004714 ; owl:annotatedTarget "septum lucidum" . [] oboInOwl:hasDbXref "BTO:0003629", "Wikipedia:Annulus_fibrosus_disci_intervertebralis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." . [] oboInOwl:hasDbXref "MA:0000111" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "annulus fibrosus" . [] oboInOwl:hasDbXref "FMA:13551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "anulus fibrosus (diskus intervertebralis)" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:12415312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000893 ; owl:annotatedTarget "An immature T cell located in the thymus." . [] oboInOwl:hasDbXref "FMA:13551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "anulus fibrosus of intervertebral disk" . [] oboInOwl:hasDbXref "BTO:0003629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "annulus fibrosus of intervertebral disc" . [] oboInOwl:hasDbXref "BTO:0003629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004715 ; owl:annotatedTarget "fibrous ring of intervertebral disc" . [] oboInOwl:hasDbXref "BTO:0003834", "Wikipedia:Conceptus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004716 ; owl:annotatedTarget "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." . [] oboInOwl:source "ncithesaurus:Conceptus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004716 ; owl:annotatedTarget "UMLS:C1516779" . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget _:genid137126 . [] oboInOwl:hasDbXref "BIRNLEX:1106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally)." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "In bony fish, or teleosts, it has been proposed that the cerebellar auricles, which receive a large amount of input from the vestibulolateral line system, constitute the vestibulocerebellum and are homologues of the flocculonodular lobe of higher vertebrates along with the corpus cerebelli, which receives spinocerebellar and tectocerebellar fibers. The labyrinth and the lateral line organs of lampreys have structural and functional similarity. An important difference between the two structures is that the arrangement of the lateral line organs are such that they are sensitive to relative motion of the fluid surrounding the animal, whereas the labyrinths, having very similar sensing mechanisms, are sensitive to endolymph, providing information concerning the animal's own equilibrium of the body and orientation in space" . [] oboInOwl:external_ontology "NIF" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "we follow MBA and NIFSTD in making this part of the cerebellar cortex, but FMA may handle this differently" . [] oboInOwl:source "BIRNLEX:1106", "ncithesaurus:Vermis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "UMLS:C0228482" . [] oboInOwl:hasDbXref "FMA:76928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "cerebellum vermis" . [] oboInOwl:hasDbXref "BIRNLEX:1175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermal parts of the cerebellum" . [] oboInOwl:hasDbXref "ABA:VERM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermal regions" . [] oboInOwl:hasDbXref "FMA:76928", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermis cerebelli [I-X]" . [] oboInOwl:hasDbXref "FMA:76928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermis of cerebellum" . [] oboInOwl:hasDbXref "FMA:76928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermis of cerebellum [I-X]" . [] oboInOwl:hasDbXref "Wikipedia:Cerebellar_vermis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermis" . [] oboInOwl:hasDbXref "Wikipedia:Cerebellar_vermis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004720 ; owl:annotatedTarget "vermis cerebelli" . [] oboInOwl:source "Wikipedia:Renal_circulation" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget obo:UBERON_0009885 . [] oboInOwl:hasDbXref "MP:0011316", "Wikipedia:Interlobular_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." . [] oboInOwl:source "ncithesaurus:Interlobular_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "UMLS:C1512856" . [] oboInOwl:hasDbXref "FMA:70498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "interlobular renal artery" . [] oboInOwl:hasDbXref "MP:0011316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "kidney interlobular artery" . [] oboInOwl:hasDbXref "Wikipedia:Interlobular_arteries" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "arteriae corticales radiatae" . [] oboInOwl:hasDbXref "Wikipedia:Interlobular_arteries" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "arteriae interlobulares renis" . [] oboInOwl:hasDbXref "Wikipedia:Interlobular_arteries" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "cortical radial arteries" . [] oboInOwl:hasDbXref "Wikipedia:Interlobular_arteries" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "interlobular" . [] oboInOwl:hasDbXref "FMA:70498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004723 ; owl:annotatedTarget "renal interlobular artery" . [] oboInOwl:hasDbXref "Wikipedia:Medial_palpebral_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004724 ; owl:annotatedTarget "The medial palpebral ligament (tendo oculi), about 4 mm. in length and 2 mm. in breadth, is attached to the frontal process of the maxilla in front of the lacrimal groove. Crossing the lacrimal sac, it divides into two parts, upper and lower, each attached to the medial end of the corresponding tarsus. As the ligament crosses the lacrimal sac, a strong aponeurotic is given off from its posterior surface; this expands over the sac, and is attached to the posterior lacrimal crest." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004724 ; owl:annotatedTarget "EMAPA:37608" . [] oboInOwl:source "ncithesaurus:Medial_Palpebral_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004724 ; owl:annotatedTarget "UMLS:C0229251" . [] oboInOwl:hasDbXref "Wikipedia:Medial_palpebral_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004724 ; owl:annotatedTarget "l. palpebrale mediale" . [] oboInOwl:hasDbXref "Wikipedia:Cochlear_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP]." . [] oboInOwl:source "ncithesaurus:Cochlear_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "UMLS:C0009201" . [] oboInOwl:hasDbXref "FMA:53431" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "auditory nerve" . [] oboInOwl:hasDbXref "FMA:53431" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "cochlear root of acoustic nerve" . [] oboInOwl:hasDbXref "FMA:53431" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "cochlear root of eighth cranial nerve" . [] oboInOwl:hasDbXref "MA:0001110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "vestibulocochlear VIII nerve cochlear component" . [] oboInOwl:hasDbXref "BTO:0003490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "nervus vestibulocochlearis" . [] oboInOwl:hasDbXref "EMAPA:17802" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004727 ; owl:annotatedTarget "vestibulocochlear nerve cochlear component" . [] oboInOwl:hasDbXref "DOI:10.1016/j.tins.2013.06.004", "https://github.com/obophenotype/uberon/issues/318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004731 ; owl:annotatedTarget "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001328" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004731 ; owl:annotatedTarget "A metameric segment of the central nervous system.[ZFA]" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004731 ; owl:annotatedTarget "neural tube metameric segment" . [] oboInOwl:hasDbXref "TAO:0001328" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004731 ; owl:annotatedTarget "neuromeres" . [] oboInOwl:hasDbXref "FBbt:00005140", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004732 ; owl:annotatedTarget "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." . [] oboInOwl:hasDbXref "FBbt:00005140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004732 ; owl:annotatedTarget "neuromere" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004733 ; owl:annotatedTarget "An organ subunit that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:61998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004733 ; owl:annotatedTarget "hindbrain segment" . [] oboInOwl:hasDbXref "FMA:61998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004733 ; owl:annotatedTarget "segment of hindbrain" . [] oboInOwl:hasDbXref "Wikipedia:Gastrula", "Wikipedia:Trilaminar_blastocyst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "Organism at the gastrula stage." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "We explicitly merge the NCITA terms here" . [] oboInOwl:source "ncithesaurus:Gastrula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "UMLS:C0017199" . [] oboInOwl:source "ncithesaurus:Trilaminar_Embryonic_Disc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "UMLS:C1284022" . [] oboInOwl:hasDbXref "BILA:0000060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "gastrula embryo" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "blastocystis trilaminaris" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "tri-laminar disc" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "tri-laminar disk" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "trilaminar blastocyst" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "trilaminar blastoderm" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "trilaminar disc" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "trilaminar disk" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004734 ; owl:annotatedTarget "trilaminar germ" . [] oboInOwl:hasDbXref "GO:0072224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004736 ; owl:annotatedTarget "Glomerulus of the mature vertebrate kidney, or metanephros." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004737 ; owl:annotatedTarget _:genid137225 . [] oboInOwl:source "Wikipedia-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004737 ; owl:annotatedTarget _:genid137227 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004737 ; owl:annotatedTarget "A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition]." . [] oboInOwl:hasDbXref "VHOG:0000983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004737 ; owl:annotatedTarget "metanephric collecting tubule" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget _:genid137236 . [] oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0099864", "GO:0072013", "GOC:mtg_kidney_jan10", "PMID:10572058", "PMID:15647339", "PMID:9268568", "XAO:0000318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "a glomus differs from a glomerulus in that each vascular glomus services several tubules" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001557" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "Paired highly vascularized portion of the pronephros. Left and right glomeruli are fused at the midline. Begins to function between 40 and 48hpf. Drummond, 2000.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001237" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:9806915 Drummond IA, Majumdar A, Hentschel H, Elger M, Solnica-Krezel L, Schier AF, Neuhauss SCF, Stemple DL, Zwartkruis F, Rangini Z, Driever W, Fishman MC, Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (1998), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.636", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "The teleost pronephros shares many essential features with the amphibian pronephros including its derivation from mesoderm associated with the coelom and the derivation of the glomerular blood supply from the medial dorsal aorta. However, unlike the pronephros of amphibians, which have an external glomus and tubules with nephrostomes open to the coelom, the mature teleost pronephros has no connection to the body cavity and instead functions as a closed system (reference 1); This variation in nephron types [with external glomeruli that open into the coelom and with internal glomeruli that do not connect with the coelom] and their pattern of distribution suggest an evolutionary sequence. Ancestral craniates probably had an external glomerulus and nephrostomes, as do the first few to develop in very primitive craniates. (...) The mechanism would become more efficient as the coelomic recess into which each glomerulus discharged became a part of the tubule, that is, grew around the glomerulus as a renal capsule. The glomerulus becomes internal. The nephrostomes were lost during subsequent evolution, leaving the type of renal tubule found in most vertebrates (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "GO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "GO treats glomus and pronephric glomerulus differently" . [] oboInOwl:hasDbXref "XAO:0000318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "glomus" . [] oboInOwl:hasDbXref "XAO:0000318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "corpuscle" . [] oboInOwl:hasDbXref "XAO:0000318" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "glomera" . [] oboInOwl:hasDbXref "VHOG:0001237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "pronephric glomera" . [] oboInOwl:hasDbXref "VHOG:0001237" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "pronephric glomeruli" . [] oboInOwl:hasDbXref "VHOG:0001237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004739 ; owl:annotatedTarget "pronephric glomus" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget obo:UBERON_0008907 . [] oboInOwl:notes "mandibular series" ; oboInOwl:source "ISBN:0073040584", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget _:genid137250 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget _:genid137252 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget _:genid137255 . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget _:genid137257 . [] oboInOwl:hasDbXref "VHOG:0001022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000191" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:GA_TG" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "Dermal bone that is usually the anteriormost bone of the lower jaw, and that articulates with the angular, or anguloarticular bone, posteriorly, and carries part of the mandibular sensory canal and pore openings of the mandibular sensory canal on its lateral surface. The dentary is a paired bone.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000124" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "Ossified element of intramembranous origin that invests the lateral margin of Meckel's cartilage thereby forming the lateral side of the mandible in anurans and salamanders (Duellman & Trueb, 1994:293). In caecilians, the dentary is part of a compound bone termed the pseudodentary.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001022" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians. In mammals the lower jaw consists entirely of the dentary bone. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, ZFA:0000191_and_Liem_KF, p.248][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000191" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "relationship loss: overlaps dentary-anguloarticular joint (TAO:0001749)[TAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000894 ; owl:annotatedTarget obo:CL_0000827 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001022" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.248", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "Of all these bones [dentary, splenials, coronoids, angular, surangular and prearticular], only the dentary remains in the lower jaw of a mammal.[well established][VHOG]" . [] oboInOwl:hasDbXref "TAO:0000191" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "dentaries" . [] oboInOwl:hasDbXref "ZFA:0000191" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "dentary bone" . [] oboInOwl:hasDbXref "AAO:0000124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "dentale" . [] oboInOwl:hasDbXref "AAO:0000124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "os dentale" . [] oboInOwl:hasDbXref "AAO:0000124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004742 ; owl:annotatedTarget "sur-angulaire" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget _:genid137270 . [] oboInOwl:hasDbXref "VSAO:0005002", "Wikipedia:Scapulocoracoid", "https://github.com/obophenotype/uberon/issues/125", "https://github.com/obophenotype/uberon/issues/66" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "Skeletal element that consists of the scapula and the coracoid[VSAO, modified]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000781" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "Fused, ossified portions of the scapula, procoracoid, and coracoid.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001455" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:GA_TG", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "Pectoral fin cartilage that consists of a paired cartilaginous plate of the embryonic primary pectoral girdle and from which the scapular and coracaoid bones ossify.[TAO]" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000894 ; owl:annotatedTarget "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." . [] oboInOwl:date_retrieved "2012-09-10" ; oboInOwl:source "http://palaeos.com/vertebrates/glossary/glossaryS.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "either a fusion of the scapula and coracoid (the two main bones of the shoulder girdle), or the scapula & coracoid considered as a single structural unit.[Palaeos]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000781" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "relationship loss: part_of scapular area (AAO:0000935)[AAO]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "ZFA defines as precursor to scapula and coracoid. Cartilage in TAO" . [] oboInOwl:hasDbXref "VSAO:0005002" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "scapulocoracoideum" . [] oboInOwl:hasDbXref "ZFA:0001455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "coraco-scapular cartilage" . [] oboInOwl:hasDbXref "TAO:0001455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "scapulo-coracoid cartilage" . [] oboInOwl:hasDbXref "TAO:0001455" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004753 ; owl:annotatedTarget "scapulocoracoid cartilage" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004755 ; owl:annotatedTarget obo:UBERON_0002384 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000015" ; oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004755 ; owl:annotatedTarget _:genid137284 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000015", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/134" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004755 ; owl:annotatedTarget "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000015" ; oboInOwl:notes "taken from version of VSAO used in TAO and used directly in Uberon" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004755 ; owl:annotatedTarget "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004755 ; owl:annotatedTarget "EMAPA:37744" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/206" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004756 ; owl:annotatedTarget "Dermis-derived entity that is made of skeletal tissue." . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004756 ; owl:annotatedTarget "dermal element" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Anal_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004760 ; owl:annotatedTarget "A gland that is part of an anal canal [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Anal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004760 ; owl:annotatedTarget "UMLS:C0162322" . _:genid136057 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004760 ; owl:annotatedTarget "gland of anal canal" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012141 . [] oboInOwl:hasDbXref "Wikipedia:Anal_gland" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004760 ; owl:annotatedTarget "anal sac" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:source "PMC1571569" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget _:genid137307 . [] oboInOwl:hasDbXref "Wikipedia:Chondrocranium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget "in contrast to chondrocranium, this structure is entirely cartiliginous. In Chondricthyes this is the same as the neurocranium. FMA:76621 is an undefined fetal structure, so we assume the correct placement is here. Note that this is distinct from MA:0000317 which is the uberon:neurocranium (the part of the cranium that encloses the brain)" . [] oboInOwl:source "ncithesaurus:Chondrocranium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget "UMLS:C1516496" . [] oboInOwl:hasDbXref "Wikipedia:Chondrocranium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget "chondocranium" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004761 ; owl:annotatedTarget "neurocranium" . [] oboInOwl:hasDbXref "GO:0001958", "VSAO:0000145", "Wikipedia:Endochondral_ossification" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004763 ; owl:annotatedTarget "Replacement bone tissue that forms within cartilage[VSAO, modified]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004763 ; owl:annotatedTarget "the distinction between endochondral bone and endochondral bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type" . [] oboInOwl:hasDbXref "GO:0001957", "Wikipedia:Intramembranous_ossification" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004764 ; owl:annotatedTarget "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004764 ; owl:annotatedTarget "note the distinction between intramembranous bone and intramembranous bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type (it is under bone tissue and connective tissue; there are no child classes)" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004765 ; owl:annotatedTarget _:genid137330 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004765 ; owl:annotatedTarget "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000128" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004765 ; owl:annotatedTarget "Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001890" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:VSAO_workshop" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004765 ; owl:annotatedTarget "Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]" . [] oboInOwl:hasDbXref "UBERON:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004766 ; owl:annotatedTarget "A bone that is part of a cranium." . [] oboInOwl:hasDbXref "UBERON:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004766 ; owl:annotatedTarget "cranium bone" . [] oboInOwl:hasDbXref "http://www.encyclo.co.uk/define/Vomerine%20teeth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004767 ; owl:annotatedTarget "A tooth that is on the vomer." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001631" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004767 ; owl:annotatedTarget "Tooth that is attached to the vomer.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001631" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0004767 ; owl:annotatedTarget "relationship type change: OBO_REL:part_of vomer (TAO:0000308) CHANGED TO: attaches_to vomer (UBERON:0002396)[TAO]" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004768 ; owl:annotatedTarget _:genid137354 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004768 ; owl:annotatedTarget "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular." . [] oboInOwl:hasDbXref "FMA:24013", "Wikipedia:Diaphysis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004769 ; owl:annotatedTarget "Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified]." . [] oboInOwl:source "FMA:24013" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004769 ; owl:annotatedTarget "Subdivision of long bone which forms the part of the bone between the two epiphyses; together with other the subdivisions of long bone, it constitutes the long bone. Examples: diaphysis of humerus, diaphysis of femur[FMA]." . [] oboInOwl:source "FMA:24013, Wikipedia:Diaphysis" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004769 ; owl:annotatedTarget "The main or mid section (shaft) of a long bone. It is made up of cortical bone and usually contains bone marrow and adipose tissue (fat)[WP][FMA:24013, Wikipedia:Diaphysis]." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004770 ; owl:annotatedTarget _:genid137364 . [] oboInOwl:hasDbXref "VSAO:0000181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004770 ; owl:annotatedTarget "Anatomical system that consists of all the joints of the body." . [] oboInOwl:hasDbXref "FMA:23878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004770 ; owl:annotatedTarget "joint system" . [] oboInOwl:hasDbXref "FMA:23878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004770 ; owl:annotatedTarget "set of all joints of body" . [] oboInOwl:hasDbXref "FMA:23878" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004770 ; owl:annotatedTarget "set of joints of body" . [] oboInOwl:hasDbXref "AAO:0000093", "Wikipedia:Posterior_nasal_apertures" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "Opening/conduit between the nasal cavity and the nasopharynx[AAO] The choanae are separated by the vomer[WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000545" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "One of the paired openings from the nasal cavities into the pharynx. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-6, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000093" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "Opening between the nasal cavity and the nasopharynx.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000545" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nature02843 Zhu M, Ahlberg PE, The origin of the internal nostril in tetrapodes. Nature (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "The choana, a unique 'internal nostril' opening from the nasal sac into the roof of the mouth, is a key part of the tetrapod (land vertebrate) respiratory system. It was the first component of the tetrapod body plan to evolve, well before the origin of limbs, and is therefore crucial to our understanding of the beginning of the fish-tetrapod transition. (...) Here we present new material of Kenichthys, a 395-million-year-old fossil fish from China, that provides direct evidence for the origin of the choana and establishes its homology: it is indeed a displaced posterior external nostril that, during a brief transitional stage illustrated by Kenichthys, separated the maxilla from the premaxilla.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "Fish don't have choanae, instead they have two pairs of external nostrils" . [] oboInOwl:hasDbXref "Wikipedia:Choane", "XAO:0000277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "choana" . [] oboInOwl:hasDbXref "MA:0001323" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "internal naris" . [] oboInOwl:hasDbXref "XAO:0000277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "posterior nasal apperture" . [] oboInOwl:hasDbXref "VHOG:0000545" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "choanae" . [] oboInOwl:hasDbXref "HP:0004496" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "posterior choana" . [] oboInOwl:hasDbXref "VHOG:0000545" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004771 ; owl:annotatedTarget "posterior naris" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget obo:UBERON_0000094 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget _:genid137391 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget _:genid137393 . [] oboInOwl:hasDbXref "Wikipedia:Tarsus_(eyelids)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "The tarsi (tarsal plates) are two comparatively thick, elongated plates of dense connective tissue, about 2.5 cm. in length; one is found in each eyelid, and contributes to its form and support. They directly abut the lid margins." . [] oboInOwl:source "PMID:16496288" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "In most taxa (birds, mammals, lizards), the tarsal plate is described as a dense, fibrous connective tissue, possibly including cartilage, present within one or both of the upper and lower eyelids (Gau- thier et al., 1988; Rieppel, 2000). In humans, the tarsal plate of the upper eyelid is composed of collagens types I, III, and V, as well as glycosaminogly- cans (chondroitin sulphate 4 and 6), aggrecan, and cartilage oligomeric matrix proteins but lacks collagen type II as well as chondrocytes (Milz et al., 2005). Thus, for humans, the upper tarsal plate represents neither a truly fibrous nor a truly cartilagi- nous element but instead one that is composed of a unique transitional tissue (Milz et al., 2005). In many birds, lizards, and Sphenodon (the tuatara), the upper eyelid has lim- ited mobility and a putative tarsal plate is instead found within the lower eyelid (Underwood, 1970; Gau- thier et al., 1988)." . [] oboInOwl:source "ncithesaurus:Tarsal_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "UMLS:C0459586" . [] oboInOwl:hasDbXref "FMA:59086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "tarsal plate" . [] oboInOwl:hasDbXref "FMA:59086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "tarsal plate of eyelid" . [] oboInOwl:hasDbXref "PMID:16496288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "tarsus palpebralis" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "eyelid tarsi" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004772 ; owl:annotatedTarget "tarsi" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "An eyelid tarsus that is part of a upper eyelid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "EMAPA:37607" . [] oboInOwl:hasDbXref "FMA:59087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "superior tarsal plate" . [] oboInOwl:hasDbXref "FMA:59087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "superior tarsus" . [] oboInOwl:hasDbXref "FMA:59087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "tarsal plate of upper eyelid" . [] oboInOwl:hasDbXref "FMA:59087", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004773 ; owl:annotatedTarget "tarsus superior" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "An eyelid tarsus that is part of a lower eyelid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "EMAPA:37606" . [] oboInOwl:hasDbXref "FMA:59088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "inferior tarsal plate" . [] oboInOwl:hasDbXref "FMA:59088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "inferior tarsus" . [] oboInOwl:hasDbXref "FMA:59088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "tarsal plate of lower eyelid" . [] oboInOwl:hasDbXref "FMA:59088", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004774 ; owl:annotatedTarget "tarsus inferior" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004777 ; owl:annotatedTarget "A submucosa that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004777 ; owl:annotatedTarget "EMAPA:37578" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004777 ; owl:annotatedTarget "apparatus respiratorius submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004777 ; owl:annotatedTarget "submucosa of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004777 ; owl:annotatedTarget "submucosa of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004778 ; owl:annotatedTarget "A submucosa that is part of a larynx [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004778 ; owl:annotatedTarget "submucosa of larynx" . [] oboInOwl:hasDbXref "EMAPA:35474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004778 ; owl:annotatedTarget "laryngeal submucosa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget _:genid137447 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "A lamina propria that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "EMAPA:37576" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "apparatus respiratorius lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "apparatus respiratorius lamina propria mucosa" . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:19100699", "PMID:22343568", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "lamina propria mucosa of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "lamina propria mucosa of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "lamina propria of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "lamina propria of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004779 ; owl:annotatedTarget "respiratory system lamina propria mucosa" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004780 ; owl:annotatedTarget _:genid137462 . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "naive CD4+ T cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004780 ; owl:annotatedTarget "A lamina propria that is part of a gastrointestinal system." . [] oboInOwl:source "ncithesaurus:Gastrointestinal_Tract_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004780 ; owl:annotatedTarget "UMLS:C1708197" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget _:genid137470 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "A lamina propria that is part of a gallbladder [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Gallbladder_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "UMLS:C1708175" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "gall bladder lamina propria" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000895 ; owl:annotatedTarget "Th0" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "gall bladder lamina propria mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "lamina propria mucosa of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "lamina propria mucosa of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "lamina propria of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "lamina propria of gallbladder" . [] oboInOwl:hasDbXref "MA:0001633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004781 ; owl:annotatedTarget "biliary lamina propria" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "A serous membrane that is part of a digestive system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "EMAPA:37592" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "digestive system serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "digestive system serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "gastrointestinal system serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "serosa of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "serosa of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "serous membrane of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004782 ; owl:annotatedTarget "serous membrane of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "A serous membrane that is part of a gallbladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "gall bladder serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "gallbladder serous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "serosa of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "serosa of gallbladder" . [] oboInOwl:hasDbXref "FMA:14659" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "serous coat of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "serous membrane of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "serous membrane of gallbladder" . [] oboInOwl:hasDbXref "FMA:14659" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "tunica serosa (vesica biliaris)" . [] oboInOwl:hasDbXref "FMA:14659", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "tunica serosa vesicae biliaris" . [] oboInOwl:hasDbXref "MA:0001634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004783 ; owl:annotatedTarget "biliary serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "anatomical wall of cardiac ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "anatomical wall of heart ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "anatomical wall of lower chamber of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "anatomical wall of ventricle of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "cardiac ventricle anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "cardiac ventricle wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "heart ventricle anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "lower chamber of heart anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "lower chamber of heart wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "ventricle of heart anatomical wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "ventricle of heart wall" . [] oboInOwl:hasDbXref "FMA:13884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "ventricular wall" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "wall of cardiac ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "wall of heart ventricle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "wall of lower chamber of heart" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "wall of ventricle of heart" . [] oboInOwl:hasDbXref "MA:0002791" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004784 ; owl:annotatedTarget "wall of ventricle" . [] oboInOwl:hasDbXref "MESH:A04.760", "MGI:cwg", "MP:0002277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "The mucous membrane lining the respiratory tract." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "EMAPA:37577" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "apparatus respiratorius mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "apparatus respiratorius mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "apparatus respiratorius mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucosa of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucosa of organ of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucosa of organ of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucosa of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucous membrane of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "mucous membrane of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "respiratory system mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "respiratory system mucous membrane" . [] oboInOwl:hasDbXref "EMAPA:18334" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "laryngeal mucous membrane" . [] oboInOwl:hasDbXref "BTO:0000973" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004785 ; owl:annotatedTarget "respiratory mucosa" . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget _:genid137556 . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget _:genid137558 . [] oboInOwl:source "PMID:16417468" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget _:genid137560 . [] oboInOwl:source "BTO-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget _:genid137562 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget "A mucosa that is part of a gastrointestinal system." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget "digestive tract mucosa" . [] oboInOwl:hasDbXref "BTO:0000546" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget "gut mucosa" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget "gut mucuous membrane" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004786 ; owl:annotatedTarget "mucosa of gut" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004789 ; owl:annotatedTarget "A mucous gland that is part of a larynx [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004789 ; owl:annotatedTarget "EMAPA:37631" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004789 ; owl:annotatedTarget "mucous gland of larynx" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004790 ; owl:annotatedTarget "A mucous gland that is part of the skin." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004790 ; owl:annotatedTarget "mucous gland of entire skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004790 ; owl:annotatedTarget "mucous gland of skin of body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004790 ; owl:annotatedTarget "skin mucus gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004790 ; owl:annotatedTarget "skin of body mucous gland" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget _:genid137592 . [] oboInOwl:hasDbXref "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002370" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "The thymic connective tissue which extends into the parenchyma." . [] oboInOwl:source "ncithesaurus:Thymic_Trabecula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "UMLS:C1515431" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "thymic trabecula" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "thymus gland trabecula" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "thymus trabeculae" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000896 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "trabecula of thymus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004791 ; owl:annotatedTarget "trabecula of thymus gland" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "A secretion that is part of a endocrine pancreas [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Pancreatic_Endocrine_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "UMLS:C1518866" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "endocrine pancreas secretion" . [] oboInOwl:hasDbXref "ncithesaurus:Pancreatic_Endocrine_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "pancreatic endocrine secretion" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000896 ; owl:annotatedTarget "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "pars endocrina pancreatis secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004792 ; owl:annotatedTarget "secretion of pars endocrina pancreatis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "A secretion that is part of a exocrine pancreas [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Pancreatic_Exocrine_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "UMLS:C1518867" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "exocrine pancreas secretion" . [] oboInOwl:hasDbXref "ncithesaurus:Pancreatic_Exocrine_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "pancreatic exocrine secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "pars exocrina pancreatis secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004793 ; owl:annotatedTarget "secretion of pars exocrina pancreatis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "A secretion that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Esophagus_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "UMLS:C0227179" . [] oboInOwl:hasDbXref "FMA:79662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "esophageal secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "gullet secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "oesophagus secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "secretion of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "secretion of gullet" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004794 ; owl:annotatedTarget "secretion of oesophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004795 ; owl:annotatedTarget "A secretion that is part of a pancreas [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Pancreatic_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004795 ; owl:annotatedTarget "UMLS:C0030296" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004795 ; owl:annotatedTarget "pancreatic secretion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004795 ; owl:annotatedTarget "secretion of pancreas" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget obo:UBERON_0006530 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "A bodily secretion that is produced by the prostate gland." . [] oboInOwl:source "ncithesaurus:Prostate_Gland_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "UMLS:C1709733" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "prostate secretion" . [] oboInOwl:hasDbXref "FMA:66884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "prostatic fluid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "secretion of prostate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "secretion of prostate gland" . [] oboInOwl:hasDbXref "BTO:0001232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004796 ; owl:annotatedTarget "prostate fluid" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004797 ; owl:annotatedTarget "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Beilstein:1723801" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "An epithelium that is part of a uterine cervix [Automatically generated definition]." . [] oboInOwl:source "Wikipedia:Cervix#Histology" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "The epithelium of the cervix is varied. The ectocervix (more distal, by the vagina) is composed of nonkeratinized stratified squamous epithelium. The endocervix (more proximal, within the uterus) is composed of simple columnar epithelium" . [] oboInOwl:source "ncithesaurus:Cervix_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "UMLS:C1711358" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "cervical canal epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "cervical canal epithelium" . [] oboInOwl:hasDbXref "BTO:0000241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "cervical epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "cervix epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004801 ; owl:annotatedTarget "epithelium of cervix" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:anna", "MP:0010942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "epithelial tissue of respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "epithelium of respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "respiratory tract epithelial tissue" . [] oboInOwl:hasDbXref "BTO:0000419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "airway epithelium" . [] oboInOwl:hasDbXref "BTO:0000419" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004802 ; owl:annotatedTarget "respiratory epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004803 ; owl:annotatedTarget "An epithelium that is part of a penis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004803 ; owl:annotatedTarget "epithelial tissue of penis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004803 ; owl:annotatedTarget "epithelium of penis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004803 ; owl:annotatedTarget "penis epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "An epithelium that is part of a oviduct [Automatically generated definition]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000897 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "epithelial tissue of oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "epithelium of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "epithelium of oviduct" . [] oboInOwl:hasDbXref "FMA:62016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "epithelium of uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "oviduct epithelial tissue" . [] oboInOwl:hasDbXref "BTO:0002402" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "columnar epithelium of the fallopian tube" . [] oboInOwl:hasDbXref "BTO:0002402" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "columnar epithelium of the oviduct" . [] oboInOwl:hasDbXref "BTO:0002402" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004804 ; owl:annotatedTarget "fallopian tube epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "An epithelium that is part of a seminal vesicle [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Seminal_Vesicle_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "UMLS:C1710049" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "epithelial tissue of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "epithelial tissue of seminal vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "epithelium of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "epithelium of seminal vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "seminal gland epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "seminal gland epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004805 ; owl:annotatedTarget "seminal vesicle epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "An epithelium that is part of a vas deferens [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Vas_Deferens_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "UMLS:C1710617" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "deferent duct epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "deferent duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "ductus deferens epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "ductus deferens epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelial tissue of deferent duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelial tissue of ductus deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelial tissue of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelial tissue of vas deferen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelial tissue of vas deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelium of deferent duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelium of ductus deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelium of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelium of vas deferen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "epithelium of vas deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "sperm duct epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "sperm duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "vas deferen epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "vas deferen epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004806 ; owl:annotatedTarget "vas deferens epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "An epithelium that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "apparatus respiratorius epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "apparatus respiratorius epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "epithelial tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "epithelial tissue of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "epithelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "epithelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004807 ; owl:annotatedTarget "respiratory system epithelial tissue" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "CAS:56-86-0" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "An epithelium that is part of a digestive system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "digestive system epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "digestive system epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "epithelial tissue of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "epithelial tissue of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "epithelium of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "epithelium of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004808 ; owl:annotatedTarget "gastrointestinal system epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004809 ; owl:annotatedTarget "An epithelium that is part of a salivary gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004809 ; owl:annotatedTarget "epithelial tissue of salivary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004809 ; owl:annotatedTarget "epithelium of salivary gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004809 ; owl:annotatedTarget "salivary gland epithelial tissue" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004810 ; owl:annotatedTarget "The cellular avascular layer of the renal tubule luminar surfaces." . [] oboInOwl:source "ncithesaurus:Renal_Tubule_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004810 ; owl:annotatedTarget "UMLS:C1709902" . [] oboInOwl:hasDbXref "MA:0001681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004810 ; owl:annotatedTarget "kidney tubule epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "An epithelium that is part of an endometrium [Automatically generated definition]." . [] oboInOwl:source "PMID:19829370" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "In rodents and primates, the uterine epithelium (the endometrium) is eroded away so that maternal blood comes into direct contact with the trophoblast surface (called haemochorial)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "endometrium epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "epithelial tissue of endometrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "epithelium of endometrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "epithelium of tunica mucosa of endometrium" . [] oboInOwl:hasDbXref "PMID:19829370" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004811 ; owl:annotatedTarget "uterine epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "An epithelium that is part of a prepuce of penis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelial tissue of prepuce" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelium of prepuce" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "prepuce epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "prepuce of penis epithelium" . [] oboInOwl:source "ncithesaurus:Prepuce_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "UMLS:C1709639" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelial tissue of foreskin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelial tissue of penile prepuce" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelial tissue of prepuce of penis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelium of foreskin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelium of penile prepuce" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "epithelium of prepuce of penis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "foreskin epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "foreskin epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "penile prepuce epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "penile prepuce epithelium" . [] oboInOwl:hasDbXref "MA:0001753" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "prepuce epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004812 ; owl:annotatedTarget "prepuce of penis epithelial tissue" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0011750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "The stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule." . [] oboInOwl:source "ncithesaurus:Seminiferous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "UMLS:C0036629" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "epithelial tissue of seminiferous tubule" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "epithelial tissue of seminiferous tubule of testis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "epithelium of seminiferous tubule" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "epithelium of seminiferous tubule of testis" . [] oboInOwl:hasDbXref "Wikipedia:Germinal_epithelium_(male)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "germinal epithelium (male)" . [] oboInOwl:hasDbXref "Wikipedia:Germinal_epithelium_(male)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "male germinal epithelium" . [] oboInOwl:hasDbXref "BTO:0001811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "seminiferous epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "seminiferous tubule epithelial tissue" . [] oboInOwl:hasDbXref "VHOG:0000631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "testis germinal epithelium" . [] oboInOwl:hasDbXref "Wikipedia:Germinal_epithelium_(male)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004813 ; owl:annotatedTarget "wall of seminiferous tubule" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004814 ; owl:annotatedTarget "An epithelium that is part of a upper respiratory tract [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004814 ; owl:annotatedTarget "epithelial tissue of upper respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004814 ; owl:annotatedTarget "epithelium of upper respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004814 ; owl:annotatedTarget "upper respiratory tract epithelial tissue" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000898 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004815 ; owl:annotatedTarget "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004815 ; owl:annotatedTarget "EMAPA:37549" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004815 ; owl:annotatedTarget "epithelial tissue of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004815 ; owl:annotatedTarget "epithelium of lower respiratory tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004815 ; owl:annotatedTarget "lower respiratory tract epithelial tissue" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "CAS:56-86-0" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19100699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000898 ; owl:annotatedTarget "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." . _:genid136602 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0001737, obo:UBERON_0002389 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "An epithelium that is part of a larynx [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Laryngeal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "UMLS:C0751258" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "epithelial tissue of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "epithelium of larynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "laryngeal epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004816 ; owl:annotatedTarget "larynx epithelial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004817 ; owl:annotatedTarget "An epithelium that is part of a lacrimal gland [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004817 ; owl:annotatedTarget "epithelial tissue of lacrimal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004817 ; owl:annotatedTarget "epithelium of lacrimal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004817 ; owl:annotatedTarget "lacrimal gland epithelial tissue" . _:genid136621 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002113, obo:UBERON_0004535 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0004967" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004819 ; owl:annotatedTarget "The cellular avascular layer of the kidney luminar surfaces." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004819 ; owl:annotatedTarget "epithelial tissue of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004819 ; owl:annotatedTarget "epithelium of kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004819 ; owl:annotatedTarget "kidney epithelial tissue" . [] oboInOwl:hasDbXref "EMAPA:35457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004819 ; owl:annotatedTarget "renal epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "Any epithelium that lines one of the bile ducts." . [] oboInOwl:source "BTO:0000417" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "The irregularly shaped proliferating bile ducts are lined by normal cuboidal epithelium." . [] oboInOwl:source "ncithesaurus:Bile_Duct_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "UMLS:C1711208" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "biliary duct epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "epithelium of bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004820 ; owl:annotatedTarget "epithelium of biliary duct" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget obo:UBERON_0000487 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget _:genid137903 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget _:genid137905 . [] oboInOwl:hasDbXref "BTO:0003511", "MP:0010898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "alveolus epithelial tissue" . [] oboInOwl:hasDbXref "MA:0001771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "alveolus epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "epithelial tissue of alveolus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "epithelium of alveolus" . [] oboInOwl:hasDbXref "FMA:63915" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "epithelium of pulmonary alveolus" . [] oboInOwl:hasDbXref "FMA:63915" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "pulmonary alveolar epithelium" . [] oboInOwl:hasDbXref "MP:0010898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "pulmonary alveolus epithelium" . [] oboInOwl:hasDbXref "EMAPA:35121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004821 ; owl:annotatedTarget "alveolar epithelium" . _:genid136658 a owl:Restriction ; owl:onProperty obo:BFO_0000050, core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0001093, obo:UBERON_0003703 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004822 ; owl:annotatedTarget "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Extrahepatic_Bile_Duct_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004822 ; owl:annotatedTarget "UMLS:C1711347" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004822 ; owl:annotatedTarget "epithelial tissue of extrahepatic bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004822 ; owl:annotatedTarget "epithelium of extrahepatic bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004822 ; owl:annotatedTarget "extrahepatic bile duct epithelial tissue" . _:genid136667 a owl:Restriction ; owl:onProperty obo:BFO_0000050, core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0003704, obo:UBERON_0004612 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004823 ; owl:annotatedTarget "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Intrahepatic_Bile_Duct_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004823 ; owl:annotatedTarget "UMLS:C1708552" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004823 ; owl:annotatedTarget "epithelial tissue of intrahepatic bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004823 ; owl:annotatedTarget "epithelium of intrahepatic bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004823 ; owl:annotatedTarget "intrahepatic bile duct epithelial tissue" . _:genid136674 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002046 ] ) ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004613 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "A medulla that is part of a thyroid [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "EMAPA:37768" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "medulla of thyroid" . _:genid136681 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "medulla of thyroid follicle" ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004614 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "medulla of thyroid gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "medulla of thyroid gland follicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "thyroid follicle medulla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "thyroid gland follicle medulla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004827 ; owl:annotatedTarget "thyroid medulla" . _:genid136692 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition]." ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004617 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "EMAPA:37788" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "skeletal muscle of urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "skeletal muscle tissue of urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "urethra skeletal muscle tissue" . [] oboInOwl:hasDbXref "MA:0001690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "urethra skeletal muscle" . _:genid136698 oboInOwl:hasDbXref "MA:0001690" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004829 ; owl:annotatedTarget "urethral skeletal muscle" ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004618 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "CAS:56-86-0" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." . _:genid136704 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "EMAPA:37583" ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004619 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "respiratory system skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "skeletal muscle of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "skeletal muscle of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "skeletal muscle tissue of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004830 ; owl:annotatedTarget "skeletal muscle tissue of respiratory system" . _:genid136710 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001134 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ; owl:onProperty core:anteriorly_connected_to ; owl:someValuesFrom obo:UBERON_0004620 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004831 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004831 ; owl:annotatedTarget "esophagus skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004831 ; owl:annotatedTarget "skeletal muscle of esophagus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "EMAPA:37393" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "anal part of perineum skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "anal part of perineum skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "anal region skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "anal triangle skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "anal triangle skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle of anal triangle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle tissue of anal part of perineum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle tissue of anal region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004832 ; owl:annotatedTarget "skeletal muscle tissue of anal triangle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004833 ; owl:annotatedTarget "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004833 ; owl:annotatedTarget "EMAPA:37642" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004833 ; owl:annotatedTarget "lip skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004833 ; owl:annotatedTarget "skeletal muscle of lip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004833 ; owl:annotatedTarget "skeletal muscle tissue of lip" . (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005171 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004834 ; owl:annotatedTarget "Smooth muscle tissue in all or part of a hepatic duct." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004834 ; owl:annotatedTarget "EMAPA:37598" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "epididymis involuntary muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "epididymis non-striated muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "epididymis smooth muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "involuntary muscle of epididymis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "non-striated muscle of epididymis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "smooth muscle of epididymis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004835 ; owl:annotatedTarget "smooth muscle tissue of epididymis" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget _:genid138028 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget _:genid138030 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:22343568", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "EMAPA:37566" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "apparatus respiratorius arterial endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "apparatus respiratorius artery endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "apparatus respiratorius endothelium of artery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "arterial endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "arterial endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "artery endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "artery endothelium of respiratory system" . _:genid136778 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "endothelium of artery of apparatus respiratorius" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001280 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "endothelium of artery of respiratory system" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000900 ; owl:annotatedTarget "naive CD8+ T cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "respiratory system artery endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004848 ; owl:annotatedTarget "respiratory system endothelium of artery" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget _:genid138051 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "EMAPA:37585" . _:genid136790 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "apparatus respiratorius endothelium of vein" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001677 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "apparatus respiratorius vein endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "apparatus respiratorius venous endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "endothelium of vein of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "endothelium of vein of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "respiratory system endothelium of vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "respiratory system vein endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "vein endothelium of apparatus respiratorius" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "vein endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "venous endothelium of apparatus respiratorius" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Drug_Central:1310" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004849 ; owl:annotatedTarget "venous endothelium of respiratory system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004850 ; owl:annotatedTarget "An endothelium that is part of a lymph node [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004850 ; owl:annotatedTarget "endothelium of lymph node" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." . [] oboInOwl:source "ncithesaurus:Aorta_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "UMLS:C1706824" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "adult aorta endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "endothelium of adult aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "endothelium of aorta" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "endothelium of trunk of aortic tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "endothelium of trunk of systemic arterial tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "trunk of aortic tree endothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "trunk of systemic arterial tree endothelium" . [] oboInOwl:hasDbXref "BTO:0000394" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004851 ; owl:annotatedTarget "aortic endothelium" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004852 ; owl:annotatedTarget "An endothelium that is part of the cardiovascular system." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001217" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0004852 ; owl:annotatedTarget "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Vascular_Endothelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004852 ; owl:annotatedTarget "UMLS:C0014261" . [] oboInOwl:hasDbXref "ZFA:0001639" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004852 ; owl:annotatedTarget "endothelia" . [] oboInOwl:hasDbXref "XAO:0000356" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004852 ; owl:annotatedTarget "vascular endothelia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004854 ; owl:annotatedTarget "A mesentery that is part of a digestive system [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004854 ; owl:annotatedTarget "EMAPA:37068" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004854 ; owl:annotatedTarget "digestive system mesentery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004854 ; owl:annotatedTarget "mesentery of digestive system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004854 ; owl:annotatedTarget "mesentery of gastrointestinal system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "A connective tissue that surrounds a skeletal muscle tissue." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "EMAPA:37743" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "connective tissue of skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "connective tissue of skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "portion of connective tissue of skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "portion of connective tissue of skeletal muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle tissue connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle tissue portion of connective tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle tissue textus connectivus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "textus connectivus of skeletal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "textus connectivus of skeletal muscle tissue" . [] oboInOwl:hasDbXref "MA:0002868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle interstitial tissue" . [] oboInOwl:hasDbXref "MA:0002868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004857 ; owl:annotatedTarget "skeletal muscle interstitum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004859 ; owl:annotatedTarget "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004859 ; owl:annotatedTarget "eye-associated gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004859 ; owl:annotatedTarget "gland of eye" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget obo:CL_0001204 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004861 ; owl:annotatedTarget "An alveolus that is part of a right lung [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Right_Lung_Alveolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004861 ; owl:annotatedTarget "UMLS:C1709959" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004861 ; owl:annotatedTarget "alveolus of right lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004862 ; owl:annotatedTarget "An alveolus that is part of a left lung [Automatically generated definition]." . _:genid136879 oboInOwl:source "ncithesaurus:Left_Lung_Alveolus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004862 ; owl:annotatedTarget "UMLS:C1708673" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000095 . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004862 ; owl:annotatedTarget "alveolus of left lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004862 ; owl:annotatedTarget "alveolus of lobe of left lung" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "A sympathetic nerve trunk that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "EMAPA:37657" . [] oboInOwl:source "ncithesaurus:Thoracic_Sympathetic_Nerve_Trunk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "UMLS:C1710393" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "nerve trunk of sympathetic nervous system of thorax" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000904 ; owl:annotatedTarget "central memory CD4+ T cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "nerve trunk of sympathetic part of autonomic division of nervous system of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "sympathetic nerve trunk of thorax" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "sympathetic nervous system nerve trunk of thorax" . [] oboInOwl:hasDbXref "FMA:6262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thoracic part of sympathetic trunk" . [] oboInOwl:hasDbXref "FMA:6262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thoracic sympathetic chain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thorax nerve trunk of sympathetic nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thorax nerve trunk of sympathetic part of autonomic division of nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thorax sympathetic nerve trunk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thorax sympathetic nervous system nerve trunk" . [] oboInOwl:hasDbXref "FMA:6262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004863 ; owl:annotatedTarget "thoracic sympathetic trunk" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Gmelin:3502" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "A vasculature that is part of a retina [Automatically generated definition]." . [] oboInOwl:hasDbXref "GO:0061298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "retina vasculature" . [] oboInOwl:hasDbXref "GO:0061298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "retina vasculature of camera-type eye" . [] oboInOwl:hasDbXref "FMA:76552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "retinal blood vessels" . [] oboInOwl:hasDbXref "FMA:76552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "retinal blood vessels set" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "retinal vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "set of blood vessels of retina" . [] oboInOwl:hasDbXref "FMA:76552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "set of retinal blood vessels" . [] oboInOwl:hasDbXref "FMA:76552", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004864 ; owl:annotatedTarget "vasa sanguinea retinae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004867 ; owl:annotatedTarget "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye." . [] oboInOwl:external_ontology "AAO" ; oboInOwl:seeAlso "https://github.com/obophenotype/uberon/issues/462" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004867 ; owl:annotatedTarget "note that the AAO and ZFA class is a cavity" . [] oboInOwl:hasDbXref "AAO:0000343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004867 ; owl:annotatedTarget "orbit" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004869 ; owl:annotatedTarget obo:UBERON_0003103 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004869 ; owl:annotatedTarget _:genid138186 . [] oboInOwl:hasDbXref "Wikipedia:Parietal_eye" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004869 ; owl:annotatedTarget "A part of the epithalamus present in some animal species. The eye may be photoreceptive and is usually associated with the pineal gland, regulating circadian rhythmicity and hormone production for thermoregulation. The parietal eye is a part of the epithalamus, which can be divided into two major parts; the epiphysis (the pineal organ, or pineal gland if mostly endocrine) and the parietal organ (often called the parietal eye, or third eye if it is photoreceptive). It arises as an anterior evagination of the pineal organ or as a separate outgrowth of the roof of the diencephalon. In some species, it protrudes through the skull.[4] The parietal eye uses a different biochemical method of detecting light than rod cells or cone cells in a normal vertebrate eye[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Parietal_eye" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004869 ; owl:annotatedTarget "parietal eye" . [] oboInOwl:hasDbXref "Wikipedia:Parietal_eye" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004869 ; owl:annotatedTarget "third eye" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004871 ; owl:annotatedTarget "Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP]." . _:genid136928 oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004871 ; owl:annotatedTarget "parietal mesoderm" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002275 . [] oboInOwl:hasDbXref "BILA:0000047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004871 ; owl:annotatedTarget "somatic mesoderm" . _:genid136930 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0001820, obo:UBERON_0000922 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004872 ; owl:annotatedTarget "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." . [] oboInOwl:external_ontology "BILA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004872 ; owl:annotatedTarget "We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors" . [] oboInOwl:hasDbXref "BILA:0000044", "http://www.drugs.com/dict/visceral-mesoderm.html", "http://www.stedmans.com/" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004872 ; owl:annotatedTarget "visceral mesoderm" . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004872 ; owl:annotatedTarget "splanchnic mesoderm" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004873 ; owl:annotatedTarget _:genid138203 . [] oboInOwl:hasDbXref "Wikipedia:Splanchnopleure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004873 ; owl:annotatedTarget "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]." . [] oboInOwl:source "ncithesaurus:Splanchnopleure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004873 ; owl:annotatedTarget "UMLS:C1519472" . [] oboInOwl:hasDbXref "Wikipedia:Intraembryonic_coelom" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004873 ; owl:annotatedTarget "ventral splanchnic mesoderm" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004874 ; owl:annotatedTarget _:genid138210 . [] oboInOwl:hasDbXref "Wikipedia:Somatopleure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004874 ; owl:annotatedTarget "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." . [] oboInOwl:source "ncithesaurus:Somatopleure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004874 ; owl:annotatedTarget "UMLS:C1519423" . [] oboInOwl:hasDbXref "Wikipedia:Nephrogenic_cord" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004875 ; owl:annotatedTarget "A portion of the urogenital ridge which is the source of much of the urinary system[WP]." . [] oboInOwl:source "ncithesaurus:Nephrogenic_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004875 ; owl:annotatedTarget "UMLS:C1283944" . [] oboInOwl:hasDbXref "Wikipedia:Nephrogenic_cord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004875 ; owl:annotatedTarget "chorda nephrogenica" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget _:genid138221 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget _:genid138223 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget _:genid138225 . [] oboInOwl:hasDbXref "MP:0011835", "MP:anna", "Wikipedia:Urogenital_folds" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget "One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]." . [] oboInOwl:hasDbXref "EMAPA:30888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget "urethral fold" . [] oboInOwl:hasDbXref "EHDAA2:0004022", "MP:0011835" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget "urogenital fold" . [] oboInOwl:hasDbXref "MP:0011835" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004876 ; owl:annotatedTarget "urogenital ridge" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004880 ; owl:annotatedTarget "The central region of trunk mesoderm. This tissue forms the notochord." . [] oboInOwl:source "ZFIN:ZDB-PUB-961014-576" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004880 ; owl:annotatedTarget "Notochord rudiment[ZFIN:ZDB-PUB-961014-576]." . [] oboInOwl:hasDbXref "ZFA:0000091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004880 ; owl:annotatedTarget "axial chorda mesoderm" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004880 ; owl:annotatedTarget "dorsal mesoderm" . [] oboInOwl:hasDbXref "ZFA:0000091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004880 ; owl:annotatedTarget "presumptive notochord" . [] oboInOwl:hasDbXref "GO:0060484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004883 ; owl:annotatedTarget "The mass of tissue made up of mesenchymal cells in the lung." . [] oboInOwl:hasDbXref "GO:0060484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004883 ; owl:annotatedTarget "lung-associated mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004883 ; owl:annotatedTarget "mesenchyme of lung" . [] oboInOwl:hasDbXref "GO:0060484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004883 ; owl:annotatedTarget "pulmonary mesenchyme" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget obo:CL_0001204 . [] oboInOwl:hasDbXref "LG:0012625", "Wikipedia:Alveolar_septum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004893 ; owl:annotatedTarget "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung." . [] oboInOwl:source "ncithesaurus:Alveolar_Septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004893 ; owl:annotatedTarget "UMLS:C1706784" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004893 ; owl:annotatedTarget "alveolar septum" . [] oboInOwl:hasDbXref "BTO:0003149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004893 ; owl:annotatedTarget "septum interalveolare" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "LG:0012626", "MP:0010903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "A wall that contains the alveoli." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "part of wall in FMA" . [] oboInOwl:source "ncithesaurus:Alveolar_Wall" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "UMLS:C0225695" . [] oboInOwl:hasDbXref "FMA:14117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "pulmonary alveolar wall" . [] oboInOwl:hasDbXref "FMA:14117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "pulmonary interalveolar septum" . [] oboInOwl:hasDbXref "FMA:14117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "wall of pulmonary alveolus" . [] oboInOwl:hasDbXref "EMAPA:35120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004894 ; owl:annotatedTarget "alveolus wall" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:15739367" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000905 ; owl:annotatedTarget "effector memory CD4+ T cell" . [] oboInOwl:hasDbXref "LG:0012628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004895 ; owl:annotatedTarget "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus." . [] oboInOwl:source "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget obo:UBERON_0000483 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget _:genid138279 . [] oboInOwl:hasDbXref "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget "The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget "we follow EHDAA2 in dividing the UGS into epithelium and lumen" . [] oboInOwl:hasDbXref "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget "UGE" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004902 ; owl:annotatedTarget "epithelium of urogenital sinus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004904 ; owl:annotatedTarget "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." . [] oboInOwl:hasDbXref "BTO:0000966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004904 ; owl:annotatedTarget "optic nerve" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004905 ; owl:annotatedTarget "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts." . ( ) . [] oboInOwl:hasDbXref "GO:0007439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004906 ; owl:annotatedTarget "A portion of the gut that is derived from ectoderm." . [] oboInOwl:hasDbXref "EMAPA:32930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004906 ; owl:annotatedTarget "gut ectoderm" . _:genid137033 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001046, obo:UBERON_0004357 . [] oboInOwl:hasDbXref "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004907 ; owl:annotatedTarget "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004907 ; owl:annotatedTarget "MA class was moved from here. See https://github.com/obophenotype/uberon/issues/509" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004907 ; owl:annotatedTarget "WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L" . [] oboInOwl:hasDbXref "GO:0048565" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0004907 ; owl:annotatedTarget "gut" . [] oboInOwl:source "ncithesaurus:Lower_Gastrointestinal_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004907 ; owl:annotatedTarget "UMLS:C0226875" . [] oboInOwl:hasDbXref "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004908 ; owl:annotatedTarget "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0004908 ; owl:annotatedTarget "WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L. In Galen, entire GI tract excludes esophagus" . [] oboInOwl:source "ncithesaurus:Upper_Gastrointestinal_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004908 ; owl:annotatedTarget "UMLS:C0226874" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004909 ; owl:annotatedTarget "An epithelium surrounding a gonad." . [] oboInOwl:source "ncithesaurus:Germinal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004909 ; owl:annotatedTarget "UMLS:C1517534" . _:genid137049 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004909 ; owl:annotatedTarget "gonad epithelium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005420 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004909 ; owl:annotatedTarget "gonadal epithelium" . [] oboInOwl:hasDbXref "FBbt:00004859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004909 ; owl:annotatedTarget "gonadal sheath" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004910 ; owl:annotatedTarget "An epithelium surrounding a testis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004910 ; owl:annotatedTarget "testis epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004911 ; owl:annotatedTarget "An epithelium surrounding an ovary." . _:genid137063 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004911 ; owl:annotatedTarget "ovarian epithelium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005419 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004911 ; owl:annotatedTarget "ovary epithelium" . [] oboInOwl:hasDbXref "FBbt:00004896" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0004911 ; owl:annotatedTarget "ovarian sheath" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004912 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004912 ; owl:annotatedTarget _:genid138339 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004912 ; owl:annotatedTarget _:genid138341 . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004912 ; owl:annotatedTarget _:genid138343 . [] oboInOwl:hasDbXref "EMAPA:16561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004912 ; owl:annotatedTarget "hepatic diverticulum" . [] oboInOwl:hasDbXref "Wikipedia:Ampulla_of_Vater" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005167" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-070212-11", "ZFIN:ZDB-PUB-080414-12" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO]" . [] oboInOwl:source "ncithesaurus:Ampulla_of_Vater" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "UMLS:C0042425" . [] oboInOwl:hasDbXref "FMA:15076", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "ampulla biliaropancreatica" . [] oboInOwl:hasDbXref "FMA:15076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "ampulla of bile duct" . [] oboInOwl:hasDbXref "ZFA:0005167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "papilla Vateri" . [] oboInOwl:hasDbXref "Wikipedia:Ampulla_of_Vater" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "ampulla Vaterii" . [] oboInOwl:hasDbXref "Wikipedia:Ampulla_of_Vater" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "ampulla hepatopancreatica" . [] oboInOwl:hasDbXref "ZFA:0005167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004913 ; owl:annotatedTarget "papilla duodeni major" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/duodenal+papilla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004914 ; owl:annotatedTarget "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." . [] oboInOwl:hasDbXref "Wikipedia:Major_duodenal_papilla" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004914 ; owl:annotatedTarget "papilla duodeni" . [] oboInOwl:hasDbXref "Wikipedia:Sphincter_of_ampulla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." . [] oboInOwl:source "ncithesaurus:Sphincter_of_Oddi" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "UMLS:C0028872" . [] oboInOwl:hasDbXref "FMA:15077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "hepatopancreatic ampullary sphincter" . [] oboInOwl:hasDbXref "FMA:15077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "musculus sphincter ampullae" . [] oboInOwl:hasDbXref "FMA:15077", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "musculus sphincter ampullae hepatopancreatica" . [] oboInOwl:hasDbXref "FMA:15077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004915 ; owl:annotatedTarget "sphincter of ampulla of vater" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:15930465" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004916 ; owl:annotatedTarget "A sphincter muscle that is part of a anal region." . [] oboInOwl:hasDbXref "Wikipedia:Urethral_sphincter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004917 ; owl:annotatedTarget "A sphincter muscle surrounding the urethra." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004917 ; owl:annotatedTarget "EMAPA:37789" . [] oboInOwl:notes "Junction of the inferior rami of the pubis and ischium to the extent of 1.25 to 2 cm." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget _:genid138388 . [] oboInOwl:notes "Junction of the inferior rami of the pubis and ischium to the extent of 1.25 to 2 cm." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget _:genid138390 . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra", "Wikipedia:External_sphincter_muscle_of_male_urethra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "EMAPA:37790" . [] oboInOwl:source "ncithesaurus:Urethralis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "UMLS:C1710586" . [] oboInOwl:hasDbXref "PMID:9879823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "m. urethralis" . [] oboInOwl:hasDbXref "MA:0002401", "PMID:9879823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "urethralis" . [] oboInOwl:hasDbXref "PMID:9879823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "urethralis muscle" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_male_urethra" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004919 ; owl:annotatedTarget "musculus sphincter urethrae membranaceae" . _:genid137126 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555, obo:UBERON_0002129 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004921 ; owl:annotatedTarget "A proximal-distal subdivision of the digestive tract." . [] oboInOwl:hasDbXref "FMA:71131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004921 ; owl:annotatedTarget "alimentary system subdivision" . [] oboInOwl:hasDbXref "FBbt:00100315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004921 ; owl:annotatedTarget "gut section" . [] oboInOwl:hasDbXref "FMA:71131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004921 ; owl:annotatedTarget "subdivision of alimentary system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004923 ; owl:annotatedTarget "A part of a wall of an organ that forms a layer." . [] oboInOwl:hasDbXref "BTO:0002113" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "The tissue underlying the tunica mucosa of the pharynx." . [] oboInOwl:hasDbXref "FMA:75144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "pharyngeal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "pharynx submucosa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000906 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "FMA:75144", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "tela submucosa pharyngea" . [] oboInOwl:hasDbXref "BTO:0002113" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "tela submucosa pharyngis" . [] oboInOwl:hasDbXref "BTO:0002113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "submucous coat of pharynx" . [] oboInOwl:hasDbXref "BTO:0002113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004924 ; owl:annotatedTarget "submucous layer of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "A submucosa that is part of a hypopharynx [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "hypopharynx submucosa" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000906 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "laryngeal pharynx submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "laryngopharynx submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "submucosa of hypopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "submucosa of laryngeal pharynx" . [] oboInOwl:hasDbXref "FMA:55072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004925 ; owl:annotatedTarget "tela submucosa (pars laryngea pharyngis)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004926 ; owl:annotatedTarget "A submucosa that is part of a cystic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004926 ; owl:annotatedTarget "cystic duct submucosa" . [] oboInOwl:hasDbXref "FMA:18013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004926 ; owl:annotatedTarget "cystic ductal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004931 ; owl:annotatedTarget "A submucosa that is part of a descending colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004931 ; owl:annotatedTarget "descending colon submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004932 ; owl:annotatedTarget "A submucosa that is part of a sigmoid colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004932 ; owl:annotatedTarget "sigmoid colon submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "A submucosa that is part of a body of stomach [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "body of stomach submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "corpus gastricum (ventriculare) submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "gastric body submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "stomach body submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "submucosa of corpus gastricum (ventriculare)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "submucosa of gastric body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004934 ; owl:annotatedTarget "submucosa of stomach body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "A submucosa that is part of a pyloric antrum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "antrum of stomach submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "pyloric antrum submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "stomach pyloric antrum submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "submucosa of antrum of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004936 ; owl:annotatedTarget "submucosa of stomach pyloric antrum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:16719819" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "A submucosa that is part of a pylorus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "pyloric part of stomach submucosa" . [] oboInOwl:hasDbXref "FMA:17462", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "pylorus submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "stomach pyloric region submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "submucosa of pyloric part of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004937 ; owl:annotatedTarget "submucosa of stomach pyloric region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004938 ; owl:annotatedTarget "A submucosa that is part of a biliary tree [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004938 ; owl:annotatedTarget "biliary tract submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004938 ; owl:annotatedTarget "biliary tree submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004938 ; owl:annotatedTarget "submucosa of biliary tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004939 ; owl:annotatedTarget "A submucosa that is part of a common bile duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004939 ; owl:annotatedTarget "common bile duct submucosa" . [] oboInOwl:hasDbXref "FMA:18011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004939 ; owl:annotatedTarget "common bile ductal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004939 ; owl:annotatedTarget "ductus choledochus (biliaris) submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004939 ; owl:annotatedTarget "submucosa of ductus choledochus (biliaris)" . _:genid137225 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001175, obo:UBERON_0005110 . _:genid137227 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004940 ; owl:annotatedTarget "A submucosa that is part of a common hepatic duct [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003220 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004940 ; owl:annotatedTarget "common hepatic duct submucosa" . [] oboInOwl:hasDbXref "FMA:18014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004940 ; owl:annotatedTarget "common hepatic ductal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004940 ; owl:annotatedTarget "hepatic duct submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004940 ; owl:annotatedTarget "submucosa of hepatic duct" . _:genid137236 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004941 ; owl:annotatedTarget "A submucosa that is part of a right hepatic duct [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007128 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004941 ; owl:annotatedTarget "right hepatic duct submucosa" . [] oboInOwl:hasDbXref "FMA:18015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004941 ; owl:annotatedTarget "right hepatic ductal submucosa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget obo:CL_0001203 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004942 ; owl:annotatedTarget "A submucosa that is part of a left hepatic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004942 ; owl:annotatedTarget "left hepatic duct submucosa" . [] oboInOwl:hasDbXref "FMA:18017" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004942 ; owl:annotatedTarget "left hepatic ductal submucosa" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . _:genid137250 oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget _:genid138527 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "BTO:0002117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "The submucous layer of the wall of the urinary bladder." . _:genid137252 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "bladder submucosa" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003278 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "submucosa of bladder" . [] oboInOwl:hasDbXref "FMA:15929", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "tela submucosa (vesica urinaria)" . _:genid137255 oboInOwl:hasDbXref "FMA:15929", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "tela submucosa vesicae" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010336 . [] oboInOwl:hasDbXref "BTO:0002117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "tela submucosa vesicae urinariae" . _:genid137257 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "urinary bladder submucosa" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003324 . [] oboInOwl:hasDbXref "BTO:0002117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004943 ; owl:annotatedTarget "submucous layer of urinary bladder" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000907 ; owl:annotatedTarget "central memory CD8+ T cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "A submucosa that is part of a neck of urinary bladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "bladder neck submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "neck of bladder submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "neck of urinary bladder submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "submucosa of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "submucosa of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "submucosa of urinary bladder neck" . _:genid137270 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "submucosa of vesical neck" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "urinary bladder neck submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004945 ; owl:annotatedTarget "vesical neck submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004946 ; owl:annotatedTarget "A submucosa that is part of a ileum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:14957" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004946 ; owl:annotatedTarget "ileal submucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004946 ; owl:annotatedTarget "ileum submucosa" . _:genid137284 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004952 ; owl:annotatedTarget "A submucosa that is part of a bronchiole [Automatically generated definition]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:CL_0007001 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004952 ; owl:annotatedTarget "bronchiole submucosa" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget _:genid138568 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "A mucosa that is part of a ureter [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "mucosa of organ of ureter" . [] oboInOwl:hasDbXref "FMA:15894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "mucosal layer of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "mucous membrane of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "organ mucosa of ureter" . [] oboInOwl:hasDbXref "FMA:15894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "tunica mucosa (ureter)" . [] oboInOwl:hasDbXref "FMA:15894", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "tunica mucosa ureteris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureter mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureter mucosa of organ" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:16892196" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureter mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureter organ mucosa" . [] oboInOwl:hasDbXref "FMA:15894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureteral mucosa" . [] oboInOwl:hasDbXref "FMA:15894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004980 ; owl:annotatedTarget "ureteric mucosa" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "A mucosa that is part of a epiglottis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "epiglottis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "epiglottis mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "epiglottis mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "epiglottis organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "mucosa of organ of epiglottis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "mucous membrane of epiglottis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004982 ; owl:annotatedTarget "organ mucosa of epiglottis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "A mucosa that is part of a vagina [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "mucosa of organ of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "mucous membrane of vagina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "organ mucosa of vagina" . [] oboInOwl:hasDbXref "FMA:19975", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "tunica mucosa vaginae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "vagina mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "vagina mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "vagina mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "vagina organ mucosa" . [] oboInOwl:hasDbXref "FMA:19975" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004983 ; owl:annotatedTarget "vaginal mucosa" . _:genid137330 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000998 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "A mucosa that is part of a seminal vesicle [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "mucosa of organ of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "mucosa of organ of seminal vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "mucosa of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "mucous membrane of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "mucous membrane of seminal vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "organ mucosa of seminal gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "organ mucosa of seminal vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal gland mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal gland mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal gland mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal gland organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal vesicle mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal vesicle mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal vesicle mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "seminal vesicle organ mucosa" . [] oboInOwl:hasDbXref "FMA:19405", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004984 ; owl:annotatedTarget "tunica mucosa glandulae vesiculosae" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "A mucosa that is part of a ejaculatory duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "ejaculatory duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "ejaculatory duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "ejaculatory duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "ejaculatory duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:19373" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "ejaculatory ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "mucosa of organ of ejaculatory duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "mucous membrane of ejaculatory duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004985 ; owl:annotatedTarget "organ mucosa of ejaculatory duct" . _:genid137364 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001000 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001434 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "A mucosa that is part of a vas deferens [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "deferent duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "deferent duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "deferent duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "deferent duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:19240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "deferent ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "ductus deferens mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "ductus deferens mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "ductus deferens mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "ductus deferens organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of ductus deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of organ of deferent duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of organ of ductus deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of organ of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of organ of vas deferen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of organ of vas deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of vas deferen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucosa of vas deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucous membrane of deferent duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucous membrane of ductus deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucous membrane of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucous membrane of vas deferen" . _:genid137391 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "mucous membrane of vas deferens" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "organ mucosa of deferent duct" . _:genid137393 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "organ mucosa of ductus deferens" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003581 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "organ mucosa of sperm duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "organ mucosa of vas deferen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "organ mucosa of vas deferens" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "sperm duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "sperm duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "sperm duct mucous membrane" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:19581495" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "sperm duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:19240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "tunica mucosa (ductus deferens)" . [] oboInOwl:hasDbXref "FMA:19240", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "tunica mucosa ductus deferentis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferen mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferen mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferen mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferen organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferens mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferens mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferens mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004986 ; owl:annotatedTarget "vas deferens organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "A mucosa that is part of a hypopharynx [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "hypopharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "hypopharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "hypopharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "hypopharynx organ mucosa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000908 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngeal pharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngeal pharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngeal pharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngeal pharynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngopharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngopharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngopharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "laryngopharynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucosa of hypopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucosa of laryngeal pharynx" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000908 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucosa of organ of hypopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucosa of organ of laryngeal pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucosa of organ of laryngopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucous membrane of hypopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucous membrane of laryngeal pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "mucous membrane of laryngopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "organ mucosa of hypopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "organ mucosa of laryngeal pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004987 ; owl:annotatedTarget "organ mucosa of laryngopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "A mucosa that is part of a cystic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "cystic duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "cystic duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "cystic duct mucous membrane" . _:genid137447 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "cystic duct organ mucosa" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004785 . [] oboInOwl:hasDbXref "FMA:14690" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "cystic ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "mucosa of organ of cystic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "mucous membrane of cystic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004988 ; owl:annotatedTarget "organ mucosa of cystic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "A mucosa that is part of a descending colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "descending colon mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "descending colon mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "descending colon mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "descending colon organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "mucosa of organ of descending colon" . _:genid137462 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "mucous membrane of descending colon" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004786 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004992 ; owl:annotatedTarget "organ mucosa of descending colon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "A mucosa that is part of a sigmoid colon [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "mucosa of organ of sigmoid colon" . _:genid137470 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "mucous membrane of sigmoid colon" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005033 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "organ mucosa of sigmoid colon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "sigmoid colon mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "sigmoid colon mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "sigmoid colon mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004993 ; owl:annotatedTarget "sigmoid colon organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "A mucosa that is part of a body of stomach [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "body of stomach mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "body of stomach mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "body of stomach mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "body of stomach organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "corpus gastricum (ventriculare) mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "corpus gastricum (ventriculare) mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "corpus gastricum (ventriculare) mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "corpus gastricum (ventriculare) organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "gastric body mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "gastric body mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "gastric body mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "gastric body organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of corpus gastricum (ventriculare)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of gastric body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of organ of body of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of organ of corpus gastricum (ventriculare)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of organ of gastric body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of organ of stomach body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucosa of stomach body" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:22219301" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucous membrane of body of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucous membrane of corpus gastricum (ventriculare)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucous membrane of gastric body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "mucous membrane of stomach body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "organ mucosa of body of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "organ mucosa of corpus gastricum (ventriculare)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "organ mucosa of gastric body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "organ mucosa of stomach body" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "stomach body mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "stomach body mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "stomach body mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004995 ; owl:annotatedTarget "stomach body organ mucosa" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget _:genid138795 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "A mucosa that is part of a pyloric antrum [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0004107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "antral mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "antrum of stomach mucosa" . [] oboInOwl:hasDbXref "GOC:add", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000909 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "antrum of stomach mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "antrum of stomach mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "antrum of stomach organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucosa of antrum of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucosa of organ of antrum of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucosa of organ of pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucosa of organ of stomach pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucosa of stomach pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucous membrane of antrum of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucous membrane of pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "mucous membrane of stomach pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "organ mucosa of antrum of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "organ mucosa of pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "organ mucosa of stomach pyloric antrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "pyloric antrum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "pyloric antrum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "pyloric antrum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "pyloric antrum organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "stomach pyloric antrum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "stomach pyloric antrum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "stomach pyloric antrum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "stomach pyloric antrum organ mucosa" . [] oboInOwl:hasDbXref "BTO:0004107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004997 ; owl:annotatedTarget "gastric antrum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "A mucosa that is part of a pylorus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucosa of organ of pyloric part of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucosa of organ of pylorus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucosa of organ of stomach pyloric region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucosa of pyloric part of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucosa of stomach pyloric region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucous membrane of pyloric part of stomach" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucous membrane of pylorus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "mucous membrane of stomach pyloric region" . _:genid137556 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "organ mucosa of pyloric part of stomach" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000172 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "organ mucosa of pylorus" . _:genid137558 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "organ mucosa of stomach pyloric region" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000696 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pyloric part of stomach mucosa" . _:genid137560 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pyloric part of stomach mucosa of organ" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002067 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pyloric part of stomach mucous membrane" . _:genid137562 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pyloric part of stomach organ mucosa" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006909 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pylorus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pylorus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pylorus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "pylorus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "stomach pyloric region mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "stomach pyloric region mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "stomach pyloric region mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "stomach pyloric region organ mucosa" . [] oboInOwl:hasDbXref "BTO:0002984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0004998 ; owl:annotatedTarget "antropyloric mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "A mucosa that is part of a biliary tree [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tract mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tract mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tract mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tract organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tree mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tree mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tree mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "biliary tree organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "mucosa of biliary tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "mucosa of organ of biliary tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "mucosa of organ of biliary tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "mucous membrane of biliary tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "mucous membrane of biliary tree" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "organ mucosa of biliary tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0004999 ; owl:annotatedTarget "organ mucosa of biliary tree" . _:genid137592 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001174 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002370 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "A mucosa that is part of a common bile duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "common bile duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "common bile duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "common bile duct mucous membrane" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "common bile duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:14688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "common bile ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "ductus choledochus (biliaris) mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "ductus choledochus (biliaris) mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "ductus choledochus (biliaris) mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "ductus choledochus (biliaris) organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "mucosa of ductus choledochus (biliaris)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "mucosa of organ of common bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "mucosa of organ of ductus choledochus (biliaris)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "mucous membrane of common bile duct" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000911 ; owl:annotatedTarget obo:CL_0002419 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "mucous membrane of ductus choledochus (biliaris)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "organ mucosa of common bile duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005000 ; owl:annotatedTarget "organ mucosa of ductus choledochus (biliaris)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "A mucosa that is part of a common hepatic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "common hepatic duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "common hepatic duct mucosa of organ" . [] oboInOwl:hasDbXref "GOC:PAM-ADD", "GOC:tfm", "ISBN:0877799148", "PMID:18395547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000911 ; owl:annotatedTarget "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "common hepatic duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "common hepatic duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:14691" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "common hepatic ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "hepatic duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "hepatic duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "hepatic duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "hepatic duct organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "mucosa of hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "mucosa of organ of common hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "mucosa of organ of hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "mucous membrane of common hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "mucous membrane of hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "organ mucosa of common hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005001 ; owl:annotatedTarget "organ mucosa of hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "A mucosa that is part of a right hepatic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "mucosa of organ of right hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "mucous membrane of right hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "organ mucosa of right hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "right hepatic duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "right hepatic duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "right hepatic duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "right hepatic duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:14692" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005002 ; owl:annotatedTarget "right hepatic ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "A mucosa that is part of a left hepatic duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "left hepatic duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "left hepatic duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "left hepatic duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "left hepatic duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:14693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "left hepatic ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "mucosa of organ of left hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "mucous membrane of left hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005003 ; owl:annotatedTarget "organ mucosa of left hepatic duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "A mucosa that is part of a right ureter [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "mucosa of organ of right ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "mucous membrane of right ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "organ mucosa of right ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "right ureter mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "right ureter mucosa of organ" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000912 ; owl:annotatedTarget obo:CL_0000911 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "right ureter mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "right ureter organ mucosa" . [] oboInOwl:hasDbXref "FMA:17806" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005004 ; owl:annotatedTarget "right ureteral mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "A mucosa that is part of a left ureter [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "left ureter mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "left ureter mucosa of organ" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18395547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000912 ; owl:annotatedTarget "A effector T cell that provides help in the form of secreted cytokines to other immune cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "left ureter mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "left ureter organ mucosa" . [] oboInOwl:hasDbXref "FMA:17807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "left ureteral mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "mucosa of organ of left ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "mucous membrane of left ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005005 ; owl:annotatedTarget "organ mucosa of left ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "A mucosa that is part of a renal pelvis [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "kidney pelvis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "kidney pelvis mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "kidney pelvis mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "kidney pelvis organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucosa of kidney pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucosa of organ of kidney pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucosa of organ of pelvis of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucosa of organ of renal pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucosa of pelvis of ureter" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Reaxys:1723801" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucous membrane of kidney pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucous membrane of pelvis of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "mucous membrane of renal pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "organ mucosa of kidney pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "organ mucosa of pelvis of ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "organ mucosa of renal pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "pelvis of ureter mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "pelvis of ureter mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "pelvis of ureter mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "pelvis of ureter organ mucosa" . [] oboInOwl:hasDbXref "FMA:17931" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "renal pelvic mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "renal pelvis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "renal pelvis mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "renal pelvis mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "renal pelvis organ mucosa" . [] oboInOwl:hasDbXref "FMA:17931", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005006 ; owl:annotatedTarget "tunica mucosa pelvis renalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "A mucosa that is part of a neck of urinary bladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "bladder neck mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "bladder neck mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "bladder neck mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "bladder neck organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of organ of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of organ of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of organ of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of organ of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of organ of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucosa of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucous membrane of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucous membrane of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucous membrane of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucous membrane of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "mucous membrane of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of bladder mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of bladder mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of bladder mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of bladder organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of urinary bladder mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of urinary bladder mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of urinary bladder mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "neck of urinary bladder organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "organ mucosa of bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "organ mucosa of neck of bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "organ mucosa of neck of urinary bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "organ mucosa of urinary bladder neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "organ mucosa of vesical neck" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "urinary bladder neck mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "urinary bladder neck mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "urinary bladder neck mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "vesical neck mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "vesical neck mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "vesical neck mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005010 ; owl:annotatedTarget "vesical neck organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "A mucosa that is part of a right uterine tube [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucosa of organ of right fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucosa of organ of right oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucosa of organ of right uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucosa of right fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucosa of right oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucous membrane of right fallopian tube" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget obo:CL_0001203 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucous membrane of right oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "mucous membrane of right uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "organ mucosa of right fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "organ mucosa of right oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "organ mucosa of right uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right fallopian tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right fallopian tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right fallopian tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right fallopian tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right oviduct mucosa" . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right oviduct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right oviduct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right oviduct organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right uterine tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right uterine tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right uterine tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005011 ; owl:annotatedTarget "right uterine tube organ mucosa" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000913 ; owl:annotatedTarget "effector memory CD8+ T cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "A mucosa that is part of a left uterine tube [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left fallopian tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left fallopian tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left fallopian tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left fallopian tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left oviduct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left oviduct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left oviduct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left oviduct organ mucosa" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "(2S)-2-aminopentanedioic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left uterine tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left uterine tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left uterine tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "left uterine tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucosa of left fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucosa of left oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucosa of organ of left fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucosa of organ of left oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucosa of organ of left uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucous membrane of left fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucous membrane of left oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "mucous membrane of left uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "organ mucosa of left fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "organ mucosa of left oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005012 ; owl:annotatedTarget "organ mucosa of left uterine tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "A mucosa that is part of a male urethra [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "male urethra mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "male urethra mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "male urethra mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "male urethra organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "mucosa of organ of male urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "mucous membrane of male urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005013 ; owl:annotatedTarget "organ mucosa of male urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "A mucosa that is part of a female urethra [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "female urethra mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "female urethra mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "female urethra mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "female urethra organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "mucosa of organ of female urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "mucous membrane of female urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005014 ; owl:annotatedTarget "organ mucosa of female urethra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "A mucosa that is part of a lacrimal sac [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "lacrimal sac mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "lacrimal sac mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "lacrimal sac mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "lacrimal sac organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "mucosa of organ of lacrimal sac" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "mucous membrane of lacrimal sac" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005017 ; owl:annotatedTarget "organ mucosa of lacrimal sac" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "A mucosa that is part of a nasal septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "mucosa of organ of nasal septum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "mucous membrane of nasal septum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "nasal septum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "nasal septum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "nasal septum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "nasal septum organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005018 ; owl:annotatedTarget "organ mucosa of nasal septum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "A mucosa that is part of a palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucosa of oral roof" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucosa of organ of oral roof" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucosa of organ of palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucosa of organ of roof of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucosa of roof of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucous membrane of oral roof" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucous membrane of palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "mucous membrane of roof of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "oral roof mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "oral roof mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "oral roof mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "oral roof organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "organ mucosa of oral roof" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "organ mucosa of palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "organ mucosa of roof of mouth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "palate mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "palate mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "palate mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "palate organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "roof of mouth mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "roof of mouth mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "roof of mouth mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005019 ; owl:annotatedTarget "roof of mouth organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "A mucosa that is part of a tongue [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:54807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "lingual mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "mucosa of organ of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "mucous membrane of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "organ mucosa of tongue" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "L-Glutamic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "tongue mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "tongue mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "tongue mucous membrane" . _:genid137903 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "tongue organ mucosa" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004894 . [] oboInOwl:hasDbXref "FMA:54807", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005020 ; owl:annotatedTarget "tunica mucosa linguae" . _:genid137905 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001724 ] ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002062 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "A mucosa that is part of a sphenoidal sinus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "mucosa of organ of sphenoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "mucosa of organ of sphenoidal sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "mucosa of sphenoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "mucous membrane of sphenoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "mucous membrane of sphenoidal sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "organ mucosa of sphenoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "organ mucosa of sphenoidal sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoid sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoid sinus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoid sinus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoid sinus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoidal sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoidal sinus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoidal sinus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005021 ; owl:annotatedTarget "sphenoidal sinus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "A mucosa that is part of a nasopharynx [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucosa of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucosa of organ of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucosa of organ of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucosa of organ of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucosa of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucous membrane of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucous membrane of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "mucous membrane of rhinopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasal part of pharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasal part of pharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasal part of pharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasal part of pharynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasopharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasopharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasopharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "nasopharynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "organ mucosa of nasal part of pharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "organ mucosa of nasopharynx" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "organ mucosa of rhinopharynx" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "rhinopharynx mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "rhinopharynx mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "rhinopharynx mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005022 ; owl:annotatedTarget "rhinopharynx organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "A mucosa that is part of a soft palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "mucosa of organ of soft palate" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "mucous membrane of soft palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "organ mucosa of soft palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "soft palate mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "soft palate mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "soft palate mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005024 ; owl:annotatedTarget "soft palate organ mucosa" . [] oboInOwl:hasDbXref "PMID:18371378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000936 ; owl:annotatedTarget "GMLP" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005025 ; owl:annotatedTarget "A mucosa that is part of a uvula [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:60030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005025 ; owl:annotatedTarget "uvula mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "A mucosa that is part of a middle ear [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "middle ear mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "middle ear mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "middle ear mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "middle ear organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "mucosa of organ of middle ear" . [] oboInOwl:hasDbXref "FMA:59663" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "mucosa of tympanic cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "mucous membrane of middle ear" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "organ mucosa of middle ear" . [] oboInOwl:hasDbXref "FMA:59663", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005026 ; owl:annotatedTarget "tunica mucosa cavitatis tympanicae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "A mucosa that is part of a frontal sinus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "frontal sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "frontal sinus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "frontal sinus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "frontal sinus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "mucosa of organ of frontal sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "mucous membrane of frontal sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005027 ; owl:annotatedTarget "organ mucosa of frontal sinus" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "L-glutamic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "A mucosa that is part of a maxillary sinus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "antrum of highmore mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "antrum of highmore mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "antrum of highmore mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "antrum of highmore organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "maxillary sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "maxillary sinus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "maxillary sinus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "maxillary sinus organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "mucosa of antrum of highmore" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "mucosa of organ of antrum of highmore" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "mucosa of organ of maxillary sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "mucous membrane of antrum of highmore" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "mucous membrane of maxillary sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "organ mucosa of antrum of highmore" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005028 ; owl:annotatedTarget "organ mucosa of maxillary sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005030 ; owl:annotatedTarget "A mucosa that adjacent_to a paranasal sinus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005030 ; owl:annotatedTarget "paranasal sinus mucosa" . _:genid138028 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "A mucosa that is part of a upper lip [Automatically generated definition]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003469 . [] oboInOwl:source "ncithesaurus:Mucosa_of_the_Upper_Lip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "UMLS:C0226933" . _:genid138030 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "mucosa of organ of upper lip" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003504 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "mucous membrane of upper lip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "organ mucosa of upper lip" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "upper labial mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "upper lip mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "upper lip mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "upper lip mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005031 ; owl:annotatedTarget "upper lip organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "A mucosa that is part of a lower lip [Automatically generated definition]." . [] oboInOwl:source "ncithesaurus:Mucosa_of_the_Lower_Lip" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "UMLS:C0226939" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "lower labial mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "lower lip mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "lower lip mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "lower lip mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "lower lip organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "mucosa of organ of lower lip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "mucous membrane of lower lip" . _:genid138051 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005032 ; owl:annotatedTarget "organ mucosa of lower lip" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003504 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "A mucosa that is part of a gallbladder [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gall bladder mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gall bladder mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gall bladder mucous membrane" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17100874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000937 ; owl:annotatedTarget "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gall bladder organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gallbladder mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gallbladder mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gallbladder mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "gallbladder organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "mucosa of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "mucosa of organ of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "mucosa of organ of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "mucous membrane of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "mucous membrane of gallbladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "organ mucosa of gall bladder" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "organ mucosa of gallbladder" . [] oboInOwl:hasDbXref "FMA:14662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "tunica mucosa (vesica biliaris)" . [] oboInOwl:hasDbXref "FMA:14662", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005033 ; owl:annotatedTarget "tunica mucosa vesicae biliaris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "A mucosa that is part of a bronchiole [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "bronchiole mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "bronchiole mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "bronchiole mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "bronchiole organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "mucosa of organ of bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "mucous membrane of bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005039 ; owl:annotatedTarget "organ mucosa of bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "bronchiolus terminalis mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "bronchiolus terminalis mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "bronchiolus terminalis mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "bronchiolus terminalis organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "mucosa of bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "mucosa of organ of bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "mucosa of organ of terminal bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "mucous membrane of bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "mucous membrane of terminal bronchiole" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "(S)-2-aminopentanedioic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "organ mucosa of bronchiolus terminalis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "organ mucosa of terminal bronchiole" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "terminal bronchiole mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "terminal bronchiole mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "terminal bronchiole mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005040 ; owl:annotatedTarget "terminal bronchiole organ mucosa" . [] oboInOwl:hasDbXref "PMID:11237469", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "in FMA this is classified as a mucosa" . [] oboInOwl:hasDbXref "FMA:56844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "mucosa of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "mucous layer of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "mucous stratum of tympanic membrane" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "tympanic membrane external middle ear cavity epithelial component" . [] oboInOwl:hasDbXref "FMA:56844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005042 ; owl:annotatedTarget "tympanic membrane mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "A mucosa that is part of a nasolacrimal duct [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "mucosa of organ of nasolacrimal duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "mucous membrane of nasolacrimal duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "nasolacrimal duct mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "nasolacrimal duct mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "nasolacrimal duct mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "nasolacrimal duct organ mucosa" . [] oboInOwl:hasDbXref "FMA:59664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "nasolacrimal ductal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005043 ; owl:annotatedTarget "organ mucosa of nasolacrimal duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "A mucosa that is part of a pharyngotympanic tube [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "auditory tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "auditory tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "auditory tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "auditory tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "internal auditory tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "internal auditory tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "internal auditory tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "internal auditory tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucosa of auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucosa of internal auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucosa of organ of auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucosa of organ of internal auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucosa of organ of pharyngotympanic tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucous membrane of auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucous membrane of internal auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucous membrane of pharyngotympanic tube" . [] oboInOwl:hasDbXref "FMA:60109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucuous membrane of eustachian tube" . [] oboInOwl:hasDbXref "FMA:60109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "mucuous membrane of pharyngotympanic tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "organ mucosa of auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "organ mucosa of internal auditory tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "organ mucosa of pharyngotympanic tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "pharyngotympanic tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "pharyngotympanic tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "pharyngotympanic tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "pharyngotympanic tube organ mucosa" . [] oboInOwl:hasDbXref "FMA:60109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "tunica mucosa (tuba auditiva)" . [] oboInOwl:hasDbXref "FMA:60109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005044 ; owl:annotatedTarget "tunica mucosa (tuba auditoria)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "A mucosa that is part of a ethmoid sinus [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "ethmoid sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "ethmoid sinus mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "ethmoid sinus mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "ethmoid sinus organ mucosa" . [] oboInOwl:hasDbXref "FMA:59776" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "ethmoidal sinus mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "mucosa of ethmoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "mucosa of organ of ethmoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "mucous membrane of ethmoid sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005045 ; owl:annotatedTarget "organ mucosa of ethmoid sinus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000941 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005046 ; owl:annotatedTarget "A mucosa that is part of a hard palate [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005046 ; owl:annotatedTarget "hard palate mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005046 ; owl:annotatedTarget "hard palate mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005046 ; owl:annotatedTarget "mucous membrane of hard palate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005046 ; owl:annotatedTarget "organ mucosa of hard palate" . (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003706 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "A mucosa that is part of a vocal cord [Automatically generated definition]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:19273629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000941 ; owl:annotatedTarget "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." . [] oboInOwl:hasDbXref "FMA:64017" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucosa of glottis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucosa of organ of true vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucosa of organ of vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucosa of true vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucosa of vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucous membrane of true vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "mucous membrane of vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "organ mucosa of true vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "organ mucosa of vocal cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "true vocal cord mucosa" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "(S)-glutamic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "true vocal cord mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "true vocal cord mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "true vocal cord organ mucosa" . _:genid138203 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "vocal cord mucosa" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "vocal cord mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "vocal cord mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "vocal cord organ mucosa" . [] oboInOwl:hasDbXref "FMA:64017" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005047 ; owl:annotatedTarget "vocal fold mucosa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000945 ; owl:annotatedTarget obo:CL_0000542 . _:genid138210 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081, obo:UBERON_0003889 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "A mucosa that is part of a fallopian tube [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "fallopian tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "fallopian tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "fallopian tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "fallopian tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucosa of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucosa of organ of fallopian tube" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucosa of organ of uterine tube" . [] oboInOwl:hasDbXref "GOC:add", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000945 ; owl:annotatedTarget "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." . [] oboInOwl:hasDbXref "FMA:18319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucosa of oviduct" . _:genid138221 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucous membrane of fallopian tube" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009196 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "mucous membrane of uterine tube" . _:genid138223 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "organ mucosa of fallopian tube" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003064 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "organ mucosa of uterine tube" . _:genid138225 oboInOwl:hasDbXref "FMA:18319", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "tunica mucosa tubae uterinae" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0012292 . [] oboInOwl:hasDbXref "FMA:18319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "uterine tubal mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "uterine tube mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "uterine tube mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "uterine tube mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005048 ; owl:annotatedTarget "uterine tube organ mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "A mucosa that is part of a uterine tube infundibulum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:18357" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "mucosa of infundibulum of fallopian tube" . [] oboInOwl:hasDbXref "FMA:18357" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "mucosa of infundibulum of oviduct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "mucosa of organ of uterine tube infundibulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "mucosa of uterine tube infundibulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "mucous membrane of uterine tube infundibulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "organ mucosa of uterine tube infundibulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "uterine tube infundibulum mucosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "uterine tube infundibulum mucosa of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "uterine tube infundibulum mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005049 ; owl:annotatedTarget "uterine tube infundibulum organ mucosa" . [] oboInOwl:hasDbXref "Wikipedia:Mediastinum_testis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005051 ; owl:annotatedTarget "The mediastinum testis is a network of fibrous connective tissue that extends from the upper to near the lower extremity of the testis, and is wider above than below. From its front and sides numerous imperfect septa (trabeculæ) are given off, which radiate toward the surface of the organ, and are attached to the tunica albuginea. They divide the interior of the organ into a number of incomplete spaces, called lobules. These are somewhat cone-shaped, being broad at their bases at the surface of the gland, and becoming narrower as they converge to the mediastinum. The mediastinum supports the rete testis and blood vessels of the testis in their passage to and from the substance of the gland[WP]." . [] oboInOwl:hasDbXref "FMA:19812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005051 ; owl:annotatedTarget "body of highmore" . [] oboInOwl:hasDbXref "FMA:19812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005051 ; owl:annotatedTarget "mediastinum of testis" . [] oboInOwl:hasDbXref "FMA:19812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005051 ; owl:annotatedTarget "testis mediastinum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005055 ; owl:annotatedTarget "An organ part that is part of a long bone [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005056 ; owl:annotatedTarget "An external genitalia that is part of a female reproductive system [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0003100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005056 ; owl:annotatedTarget "external female genital organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005056 ; owl:annotatedTarget "external genitalia of female reproductive system" . [] oboInOwl:hasDbXref "FMA:45649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005056 ; owl:annotatedTarget "female external genitalia" . [] oboInOwl:hasDbXref "BTO:0003100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005056 ; owl:annotatedTarget "organa genitalia feminina externa" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000946 ; owl:annotatedTarget obo:CL_0000945 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005057 ; owl:annotatedTarget "An organ that is part of a immune system [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005058 ; owl:annotatedTarget "A gland that is part of a hemolymphoid system [Automatically generated definition]." . [] oboInOwl:hasDbXref "GO:0048534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005058 ; owl:annotatedTarget "hemopoietic or lymphoid organ" . _:genid138279 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005058 ; owl:annotatedTarget "hemopoietic or lymphoid gland" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009846 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000946 ; owl:annotatedTarget "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." . [] oboInOwl:hasDbXref "EMAPA:18766" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005058 ; owl:annotatedTarget "haemolymphoid system gland" . [] oboInOwl:hasDbXref "GO:0001842", "Wikipedia:Neural_groove", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005061 ; owl:annotatedTarget "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." . [] oboInOwl:source "Wikipedia:Neural_groove" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005061 ; owl:annotatedTarget "The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]." . [] oboInOwl:source "ncithesaurus:Neural_Groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005061 ; owl:annotatedTarget "UMLS:C0814992" . [] oboInOwl:hasDbXref "GO:0001842", "MP:0011256", "Wikipedia:Neural_fold" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005062 ; owl:annotatedTarget "One of the two elevated edges of the neural groove[GO,MP]." . [] oboInOwl:source "Wikipedia:Neural_fold" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005062 ; owl:annotatedTarget "In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]." . [] oboInOwl:source "ncithesaurus:Neural_Fold" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005062 ; owl:annotatedTarget "UMLS:C0814993" . [] oboInOwl:hasDbXref "MP:0011256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005062 ; owl:annotatedTarget "medullary fold" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005064 ; owl:annotatedTarget _:genid139575 . [] oboInOwl:hasDbXref "GO:0003225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005064 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "E" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005066 ; owl:annotatedTarget _:genid139582 . [] oboInOwl:hasDbXref "GO:0003227" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005066 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "GO:0014024", "ZFA:0000133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005068 ; owl:annotatedTarget "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000133" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005068 ; owl:annotatedTarget "An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO]" . [] oboInOwl:hasDbXref "GO:0014027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005068 ; owl:annotatedTarget "neural tube rod" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget _:genid139597 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001367" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "The boundary between the diencephalon and the mesencephalon.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001367" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "relationship loss: develops_from forebrain midbrain boundary neural tube (TAO:0007040)[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "diencephalic-mesencephalic boundary" . [] oboInOwl:hasDbXref "ZFA:0001367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "forebrain midbrain boundary" . [] oboInOwl:hasDbXref "EMAPA:36449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005075 ; owl:annotatedTarget "forebrain-midbrain boundary region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005076 ; owl:annotatedTarget "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000948 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "GO:0035502" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005080 ; owl:annotatedTarget "The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]." . _:genid138339 oboInOwl:hasDbXref "GO:0035503" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005081 ; owl:annotatedTarget "The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002423 . [] oboInOwl:hasDbXref "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000948 ; owl:annotatedTarget "A class switched memory B cell that expresses IgE on the cell surface." . (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0000025 ] ) . ( ) . [] oboInOwl:hasDbXref "GO:0060609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005082 ; owl:annotatedTarget "A hole in a tube[GO]." . [] oboInOwl:hasDbXref "GO:0060788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005085 ; owl:annotatedTarget "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]." . [] oboInOwl:external_ontology "GO" ; oboInOwl:source "https://github.com/geneontology/go-ontology/issues/12223#issuecomment-215692347" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005085 ; owl:annotatedTarget "in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures" . [] oboInOwl:hasDbXref "AEO:0000112" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005085 ; owl:annotatedTarget "epithelial placode" . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget _:genid139637 . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate." . [] oboInOwl:source "GO:0060789" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud[GO]." . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "hair placode" . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "hair gem" . [] oboInOwl:hasDbXref "DOI:10.1016/j.cub.2008.12.005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "hair germ" . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005086 ; owl:annotatedTarget "hair peg" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:notes "check for other species" ; oboInOwl:source "Wikipedia:Tooth_development" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget _:genid139650 . [] oboInOwl:hasDbXref "GO:0060790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001153" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "Placode that develops into a tooth. The placode is a thickening of the pharyngeal epithelium.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "dental placode" . [] oboInOwl:hasDbXref "ZFA:0001153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "dental primordium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "odontogenic placode" . [] oboInOwl:hasDbXref "MP:0000117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "tooth anlage" . [] oboInOwl:hasDbXref "MP:0000117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "tooth primordium" . [] oboInOwl:hasDbXref "ZFA:0001153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005087 ; owl:annotatedTarget "tooth germ" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005088 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005088 ; owl:annotatedTarget _:genid139665 . [] oboInOwl:hasDbXref "GO:0060791" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005088 ; owl:annotatedTarget "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005089 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005089 ; owl:annotatedTarget _:genid139673 . _:genid138388 oboInOwl:hasDbXref "GO:0060793" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005089 ; owl:annotatedTarget "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001274 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000949 ; owl:annotatedTarget obo:CL_0000980 . _:genid138390 oboInOwl:hasDbXref "GO:0061061" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005090 ; owl:annotatedTarget "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001275 . [] oboInOwl:hasDbXref "FMA:30316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005090 ; owl:annotatedTarget "musculus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005092 ; owl:annotatedTarget obo:UBERON_0002050 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000489" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005092 ; owl:annotatedTarget "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005092 ; owl:annotatedTarget "sinus venosus right horn" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005095 ; owl:annotatedTarget _:genid139684 . [] oboInOwl:hasDbXref "GO:0072003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005095 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005095 ; owl:annotatedTarget "kidney anlage" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "GLUTAMIC ACID" . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000949 ; owl:annotatedTarget "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005103 ; owl:annotatedTarget "An epithelium that is part of a mesonephros [Automatically generated definition]." . [] oboInOwl:hasDbXref "GO:0072173" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005106 ; owl:annotatedTarget "A metanephric tubule is an epithelial tube that is part of the metanephros[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001526" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005106 ; owl:annotatedTarget "The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes.[well established][VHOG]" . [] oboInOwl:hasDbXref "GO:0072207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005108 ; owl:annotatedTarget "An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO]." . [] oboInOwl:hasDbXref "GO:0072208", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005109 ; owl:annotatedTarget "Any smooth muscle tissue that is part of a metanephros." . [] oboInOwl:source "Wikipedia", "Wikipedia:Nephron" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005110 ; owl:annotatedTarget _:genid139713 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005110 ; owl:annotatedTarget _:genid139715 . [] oboInOwl:hasDbXref "GO:0072273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005110 ; owl:annotatedTarget "A metanephric nephron is the functional unit of the metanephros[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000719" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1093/icb/34.4.542 Ruppert EE, Evolutionary Origin of the Vertebrate Nephron. Integrative and Comparative Biology (1994)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005110 ; owl:annotatedTarget "The primitive form of the vertebrate nephron consists of a vascular filtration surface overlain with podocytes, a specialized coelomic cavity to receive the ultrafiltrate, and a tubule for modification to final urine. Although previously thought to be unique to the vertebrates, this design is now known to be widespread among invertebrates, including most of the protochordates, and especially their larvae.[well established][VHOG]" . [] oboInOwl:hasDbXref "GO:0072211" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005111 ; owl:annotatedTarget "Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005113 ; owl:annotatedTarget _:genid139724 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005115 ; owl:annotatedTarget _:genid139730 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005115 ; owl:annotatedTarget _:genid139732 . [] oboInOwl:hasDbXref "GO:0072219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005115 ; owl:annotatedTarget "The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005133 ; owl:annotatedTarget _:genid139739 . [] oboInOwl:hasDbXref "GO:0072239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005133 ; owl:annotatedTarget "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000950 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005134 ; owl:annotatedTarget _:genid139746 . [] oboInOwl:hasDbXref "GO:0072243" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005134 ; owl:annotatedTarget "The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005135 ; owl:annotatedTarget _:genid139753 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005135 ; owl:annotatedTarget _:genid139755 . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000950 ; owl:annotatedTarget "A plasmablast that secretes IgE." . [] oboInOwl:hasDbXref "GO:0072244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005135 ; owl:annotatedTarget "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005136 ; owl:annotatedTarget _:genid139762 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005136 ; owl:annotatedTarget _:genid139764 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005136 ; owl:annotatedTarget _:genid139766 . [] oboInOwl:hasDbXref "GO:0072264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005136 ; owl:annotatedTarget "The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO]." . [] oboInOwl:hasDbXref "GO:0072213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005137 ; owl:annotatedTarget "The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005144 ; owl:annotatedTarget _:genid139778 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005144 ; owl:annotatedTarget _:genid139780 . [] oboInOwl:hasDbXref "GO:0072277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005144 ; owl:annotatedTarget "This process pertains to the initial formation of a structure from unspecified parts[GO]." . [] oboInOwl:hasDbXref "GO:0072278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005145 ; owl:annotatedTarget "The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005146 ; owl:annotatedTarget _:genid139792 . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005146 ; owl:annotatedTarget _:genid139794 . [] oboInOwl:hasDbXref "GO:0072282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005146 ; owl:annotatedTarget "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005147 ; owl:annotatedTarget _:genid139801 . [] oboInOwl:hasDbXref "GO:0072283" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005147 ; owl:annotatedTarget "The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Glu" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005148 ; owl:annotatedTarget _:genid139809 . [] oboInOwl:hasDbXref "GO:0072284" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005148 ; owl:annotatedTarget "The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." . [] oboInOwl:hasDbXref "GO:0060572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005153 ; owl:annotatedTarget "A bud is a protrusion that forms from an epithelial sheet by localized folding." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005154 ; owl:annotatedTarget obo:UBERON_0000486 . [] oboInOwl:hasDbXref "AEO:0000216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005154 ; owl:annotatedTarget "A cord of epithelial cells without a lumen and usually several cells thick." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005156 ; owl:annotatedTarget "Any anatomical structure that is part of the reproductive system." . [] oboInOwl:hasDbXref "GO:0060571" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005157 ; owl:annotatedTarget "An epithelial sheet bent on a linear axis." . [] oboInOwl:hasDbXref "CL:tm", "https://github.com/obophenotype/uberon/issues/8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005158 ; owl:annotatedTarget "The functional tissue of the central nervous system consisting of neurons and glial cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005158 ; owl:annotatedTarget "CNS parenchyma" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005158 ; owl:annotatedTarget "central nervous system parenchyma" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005158 ; owl:annotatedTarget "parenchyma of CNS" . [] oboInOwl:hasDbXref "CARO:0001000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005162 ; owl:annotatedTarget "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." . [] oboInOwl:external_ontology "CARO", "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005162 ; owl:annotatedTarget "we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'" . [] oboInOwl:hasDbXref "CARO:0001000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005162 ; owl:annotatedTarget "multi-cell-component structure" . _:genid138527 oboInOwl:hasDbXref "CARO:0001000" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005162 ; owl:annotatedTarget "multi-cell-part structure" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 . [] oboInOwl:hasDbXref "FMA:83115" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005162 ; owl:annotatedTarget "cell part cluster" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005169 ; owl:annotatedTarget obo:UBERON_0003891 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005169 ; owl:annotatedTarget "Connective tissue between the cellular elements of a structure." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005171 ; owl:annotatedTarget "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001100" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005171 ; owl:annotatedTarget "A duct that carries bile from the liver to the small intestine.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000219" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/hepatic+duct" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005171 ; owl:annotatedTarget "The excretory duct of the liver or one of its branches in the lobes of the liver. [TFD][VHOG]" . [] oboInOwl:source "GO:0061011" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005171 ; owl:annotatedTarget "The hepatic duct is the duct that leads from the liver to the bile duct[GO]." . [] oboInOwl:source "ncithesaurus:Hepatic_Duct" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005171 ; owl:annotatedTarget "UMLS:C0917710" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005172 ; owl:annotatedTarget "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." . [] oboInOwl:hasDbXref "MA:0000522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005172 ; owl:annotatedTarget "abdomen organ" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005173 ; owl:annotatedTarget "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005173 ; owl:annotatedTarget "EMAPA:37062" . [] oboInOwl:hasDbXref "MA:0000529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005173 ; owl:annotatedTarget "abdominal segment organ" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005174 ; owl:annotatedTarget "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005174 ; owl:annotatedTarget "EMAPA:37274" . [] oboInOwl:hasDbXref "MA:0001901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005174 ; owl:annotatedTarget "back organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005175 ; owl:annotatedTarget "An organ that is part of a chest [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005175 ; owl:annotatedTarget "EMAPA:37272" . _:genid138568 oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010747", "Wikipedia:Enamel_organ", "https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107", "https://github.com/obophenotype/uberon/issues/1313" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005176 ; owl:annotatedTarget "A circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009916 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005138" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005176 ; owl:annotatedTarget "A structure that is involved in tooth formation. A bell shape two layer epithelial structure that descends toward the ceratobranchial 5 bone, enclosing the dental mesenchyme. At later times in tooth development the cells at the apex of the bell may be involved in enameloid formation. This structure remains at the base of the erupted tooth and is the source of replacement teeth.[TAO]" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000952 ; owl:annotatedTarget obo:CL_0000957 . [] oboInOwl:hasDbXref "ZFA:0005138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005176 ; owl:annotatedTarget "dental organ" . [] oboInOwl:hasDbXref "MP:0010747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005176 ; owl:annotatedTarget "enamel organ" . [] oboInOwl:hasDbXref "Wikipedia:Enamel_organ" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005176 ; owl:annotatedTarget "organum enameleum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005177 ; owl:annotatedTarget "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005177 ; owl:annotatedTarget "EMAPA:37270" . [] oboInOwl:hasDbXref "MA:0000516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005177 ; owl:annotatedTarget "trunk organ" . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000952 ; owl:annotatedTarget "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005178 ; owl:annotatedTarget "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005178 ; owl:annotatedTarget "EMAPA:37273" . [] oboInOwl:hasDbXref "MA:0000557" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005178 ; owl:annotatedTarget "thoracic cavity organ" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005179 ; owl:annotatedTarget "An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005179 ; owl:annotatedTarget "EMAPA:37275" . [] oboInOwl:hasDbXref "MA:0000543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005179 ; owl:annotatedTarget "pelvis organ" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "Glutamate" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005181 ; owl:annotatedTarget "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005181 ; owl:annotatedTarget "EMAPA:37271" . [] oboInOwl:hasDbXref "MA:0000563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005181 ; owl:annotatedTarget "upper body organ" . [] oboInOwl:hasDbXref "Wikipedia:Bone_marrow_of_ovary_(hair)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005184 ; owl:annotatedTarget "Innermost layer of the hair shaft." . [] oboInOwl:hasDbXref "BTO:0004671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005184 ; owl:annotatedTarget "medulla of hair shaft" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005185 ; owl:annotatedTarget "The portion of the collecting duct that resides in the renal medulla." . [] oboInOwl:hasDbXref "MA:0002935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005185 ; owl:annotatedTarget "kidney medulla collecting duct" . [] oboInOwl:hasDbXref "EMAPA:28061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005185 ; owl:annotatedTarget "medullary collecting duct" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget _:genid139929 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget _:genid139931 . [] oboInOwl:hasDbXref "Wikipedia:Artery_to_the_ductus_deferens" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget "An artery in males that provides blood to the vas deferens. The artery usually arises from the anterior trunk of the superior vesical artery. It accompanies the vas deferens into the testis, where it anastomoses with the testicular artery. In this way it also supplies blood to the testis and epididymis. A small branch supplies the ureter[WP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget "EMAPA:37513" . [] oboInOwl:hasDbXref "Wikipedia:Artery_to_the_ductus_deferens" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget "arteria ductus deferentis" . [] oboInOwl:hasDbXref "FMA:18930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget "artery of ductus deferens" . [] oboInOwl:hasDbXref "FMA:18930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005192 ; owl:annotatedTarget "ductus deferens artery" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005193 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "FMA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005193 ; owl:annotatedTarget _:genid139943 . [] oboInOwl:hasDbXref "Wikipedia:Ethmoidal_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005193 ; owl:annotatedTarget "One of: anterior or posterior ethmoidal arteries." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005193 ; owl:annotatedTarget "EMAPA:37081" . [] oboInOwl:source "ncithesaurus:Ethmoidal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005193 ; owl:annotatedTarget "UMLS:C0226184" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005194 ; owl:annotatedTarget "A vein that is part of a thorax [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005194 ; owl:annotatedTarget "EMAPA:37197" . [] oboInOwl:source "ncithesaurus:Thoracic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005194 ; owl:annotatedTarget "UMLS:C0226629" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005195 ; owl:annotatedTarget "A vein that is part of a vas deferens [Automatically generated definition]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005195 ; owl:annotatedTarget "EMAPA:37514" . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget _:genid139965 . [] oboInOwl:hasDbXref "CL:tm", "https://github.com/obophenotype/uberon/issues/6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." . [] oboInOwl:source "ncithesaurus:Spleen_Germinal_Center" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget "UMLS:C1710156" . [] oboInOwl:hasDbXref "MP:0008474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget "spleen GC" . [] oboInOwl:hasDbXref "MP:0008474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget "spleen follicle center" . [] oboInOwl:hasDbXref "MP:0008474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005196 ; owl:annotatedTarget "splenic germinal center" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005199 ; owl:annotatedTarget "A mammary gland that is part of a cervical region." . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005200 ; owl:annotatedTarget _:genid139982 . [] oboInOwl:hasDbXref "Wikipedia:Mammary_gland#Other_mammals", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005200 ; owl:annotatedTarget "A lactiferous gland that is located in the thoracic region/breast." . [] oboInOwl:hasDbXref "FMA:62088" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005200 ; owl:annotatedTarget "lactiferous gland" . [] oboInOwl:hasDbXref "FMA:62088" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005200 ; owl:annotatedTarget "mammary gland" . [] oboInOwl:hasDbXref "Wikipedia:Mammary_gland#Other_mammals" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005200 ; owl:annotatedTarget "anterior mammary gland" . [] oboInOwl:hasDbXref "ISBN:1451113412", "MGI:Anna", "PMID:15973734", "http://medical-dictionary.thefreedictionary.com/tracheal+glands", "https://github.com/obophenotype/uberon/issues/1197" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005203 ; owl:annotatedTarget "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." . [] oboInOwl:hasDbXref "FMA:7473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005203 ; owl:annotatedTarget "glandula trachealis" . [] oboInOwl:hasDbXref "FMA:7473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005203 ; owl:annotatedTarget "tracheal gland" . [] oboInOwl:hasDbXref "FMA:7473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005203 ; owl:annotatedTarget "tubular seromucous gland of trachea" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000953 ; owl:annotatedTarget obo:CL_0000957 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005204 ; owl:annotatedTarget "A gland that is part of a larynx submucosa [Automatically generated definition]." . [] oboInOwl:hasDbXref "EMAPA:35475" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005204 ; owl:annotatedTarget "laryngeal submucosa gland" . [] oboInOwl:hasDbXref "MA:0002737" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005205 ; owl:annotatedTarget "vagina stroma" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "L-Glu" . [] oboInOwl:hasDbXref "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000953 ; owl:annotatedTarget "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." . [] oboInOwl:hasDbXref "PMCID:PMC3496674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005206 ; owl:annotatedTarget "Stromal matrix surrounding blood vessels within the choroid plexus." . [] oboInOwl:hasDbXref "PMCID:PMC3496674" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005206 ; owl:annotatedTarget "choroid plexus stromal matrix" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005207 ; owl:annotatedTarget "A capsule that is part of a tonsil [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005208 ; owl:annotatedTarget "A valve that is part of a right atrium [Automatically generated definition]." . [] oboInOwl:hasDbXref "EMAPA:17327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005208 ; owl:annotatedTarget "valve of right atrium" . [] oboInOwl:hasDbXref "EHDAA2:0000302" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005208 ; owl:annotatedTarget "right atrium valves" . [] oboInOwl:hasDbXref "EMAPA:17327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005208 ; owl:annotatedTarget "superior vena cava valve" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget _:genid140034 . [] oboInOwl:hasDbXref "Wikipedia:Bone_marrow_of_ovaryry_interstitium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget "Tissue surrounding the loop of Henle in the renal medulla." . [] oboInOwl:hasDbXref "MA:0002619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget "kidney medulla interstitium" . [] oboInOwl:hasDbXref "EMAPA:18326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget "renal medullary interstitium" . [] oboInOwl:hasDbXref "Wikipedia:Medullary_interstitium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget "medullary interstitium" . [] oboInOwl:hasDbXref "EMAPA:18326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005211 ; owl:annotatedTarget "medullary stroma" . [] oboInOwl:hasDbXref "MESH:A05.360.444.849" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "interstitium of testis" . [] oboInOwl:hasDbXref "EMAPA:18687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "interstitium of the testis" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "testis - interstitial" . [] oboInOwl:hasDbXref "MA:0002713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "testis interstitial tissue" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005212 ; owl:annotatedTarget "testis interstitium" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget _:genid140059 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget _:genid140061 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget "A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition]." . [] oboInOwl:hasDbXref "EMAPA:28364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget "inner medullary interstitium" . [] oboInOwl:hasDbXref "MA:0002620" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget "kidney inner medulla interstitium" . [] oboInOwl:hasDbXref "EMAPA:28364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005214 ; owl:annotatedTarget "papillary interstitium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget obo:UBERON_0003891 . [] oboInOwl:hasDbXref "DOI:10.1038/ki.1991.49", "PMID:18575881", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget "The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes." . [] oboInOwl:hasDbXref "FMA:70983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget "renal interstitium" . [] oboInOwl:hasDbXref "FMA:70983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget "renal stroma" . [] oboInOwl:hasDbXref "FMA:70983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget "stroma of kidney" . [] oboInOwl:hasDbXref "EMAPA:28518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005215 ; owl:annotatedTarget "kidney interstitium group" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005216 ; owl:annotatedTarget _:genid140083 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005216 ; owl:annotatedTarget "An external ectoderm that is part of a optic eminence [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005217 ; owl:annotatedTarget "A subarachnoid space that is part of a midbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001304" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005217 ; owl:annotatedTarget "Subarachnoid space that is part of the midbrain. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005217 ; owl:annotatedTarget "subarachnoid space midbrain" . [] oboInOwl:hasDbXref "VHOG:0001304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005217 ; owl:annotatedTarget "subarachnoid space mesencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005218 ; owl:annotatedTarget "A subarachnoid space that is part of a diencephalon [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001302" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005218 ; owl:annotatedTarget "Subarachnoid space that is part of the diencephalon. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005218 ; owl:annotatedTarget "subarachnoid space diencephalon" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005219 ; owl:annotatedTarget "A subarachnoid space that is part of a hindbrain [Automatically generated definition]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001303" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005219 ; owl:annotatedTarget "Subarachnoid space that is part of the hindbrain. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005219 ; owl:annotatedTarget "subarachnoid space hindbrain" . [] oboInOwl:hasDbXref "VHOG:0001303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005219 ; owl:annotatedTarget "subarachnoid space rhombencephalon" . (obo:UBERON_0000353 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001114 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005221 ; owl:annotatedTarget "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005221 ; owl:annotatedTarget "parenchyma of right lobe of liver" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "L-Glutaminic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005222 ; owl:annotatedTarget "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:71658" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005222 ; owl:annotatedTarget "parenchyma of left lobe of liver" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005225 ; owl:annotatedTarget _:genid140125 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005225 ; owl:annotatedTarget "An epithelium that is part of a hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005226 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005226 ; owl:annotatedTarget _:genid140133 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005226 ; owl:annotatedTarget "An epithelium that is part of a toe [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005226 ; owl:annotatedTarget "hind limb digit epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005226 ; owl:annotatedTarget "foot digit epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005227 ; owl:annotatedTarget _:genid140142 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005227 ; owl:annotatedTarget "An epithelium that is part of a finger [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005227 ; owl:annotatedTarget "fore limb digit epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005227 ; owl:annotatedTarget "hand digit epithelium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000954 ; owl:annotatedTarget obo:CL_0000955 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005228 ; owl:annotatedTarget _:genid140151 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005228 ; owl:annotatedTarget "An epithelium that is part of a forelimb stylopod [Automatically generated definition]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005229 ; owl:annotatedTarget _:genid140158 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000954 ; owl:annotatedTarget "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005229 ; owl:annotatedTarget "An epithelium that is part of a lower leg [Automatically generated definition]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005233 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005233 ; owl:annotatedTarget _:genid140166 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005233 ; owl:annotatedTarget "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005234 ; owl:annotatedTarget "An ectoderm that is part of a optic eminence [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0003382", "Wikipedia:Vestibule_of_the_ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "A small, oval, bony chamber of the labyrinth. The vestibule contains the utricle and saccule, organs which are part of the balancing apparatus of the ear." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001220" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "The vestibule is the central part of the osseous labyrinth, and is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals. [Wikipedia:Vestibule_of_the_ear][VHOG]" . [] oboInOwl:hasDbXref "MP:0000034", "XAO:0000199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibule" . [] oboInOwl:source "ncithesaurus:Vestibule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "UMLS:C0458718" . [] oboInOwl:hasDbXref "BTO:0003382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "inner ear vestibulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "osseous labyrinth vestibule" . [] oboInOwl:hasDbXref "FMA:60183" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibule of bony labyrinth" . [] oboInOwl:hasDbXref "BTO:0003382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "inner ear vestibule" . [] oboInOwl:hasDbXref "GAID:881" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibular apparatus" . [] oboInOwl:hasDbXref "FMA:60183" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibular part of bony labyrinth" . [] oboInOwl:hasDbXref "Wikipedia:Vestibule_of_the_ear" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibulum auris" . [] oboInOwl:hasDbXref "Wikipedia:Vestibule_of_the_ear" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005236 ; owl:annotatedTarget "vestibulum labyrinthi" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000320" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005239 ; owl:annotatedTarget "The ventral half of the developing neural tube that is the metencephalon. [Chordate_evolution_and_the_origin_of_craniates:_An_old_brain_in_a_new_head._AnaT_Rec_(New_Anat)_(2000)_261(3):_111-125, See_Butler_AB][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005239 ; owl:annotatedTarget "metencephalon basal plate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005243 ; owl:annotatedTarget "An endocardium that is part of a interventricular septum [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:83584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005243 ; owl:annotatedTarget "endocardium of interventricular septum" . [] oboInOwl:hasDbXref "VHOG:0000615" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005243 ; owl:annotatedTarget "interventricular septum endocardial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005248 ; owl:annotatedTarget "A myocardium that is part of a bulbus cordis [Automatically generated definition]." . [] oboInOwl:hasDbXref "VHOG:0000609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005248 ; owl:annotatedTarget "bulbus cordis cardiac muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005249 ; owl:annotatedTarget "A renal pelvis that is part of a metanephros." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000945" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005249 ; owl:annotatedTarget "The ureteric bud itself forms the collecting tubules and the ureter that drain the adult kidney. This type of kidney, called the metanephros, occurs in all adult amniotes.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005249 ; owl:annotatedTarget "metanephros pelvis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005250 ; owl:annotatedTarget "A gland that is part of a stomodeum." . [] oboInOwl:hasDbXref "VHOG:0000658" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005250 ; owl:annotatedTarget "stomatodaeum gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005251 ; owl:annotatedTarget "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "L-Glutaminsaeure" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0005251 ; owl:annotatedTarget "In mammals, the yolk sac cavity contains fluid rather than platelets" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005251 ; owl:annotatedTarget "in EHDAA2, there are separate primary and secondary yolk sac cavities" . [] oboInOwl:hasDbXref "FMA:63942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005251 ; owl:annotatedTarget "cavity of yolk sac" . [] oboInOwl:hasDbXref "FMA:63942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005251 ; owl:annotatedTarget "yolk sac space" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget _:genid140229 . [] oboInOwl:hasDbXref "ISBN:0683400088", "MP:0011260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000113" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget "Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO]" . [] oboInOwl:hasDbXref "MP:0011260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget "cephalic mesenchyme" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget "cranial mesenchyme" . [] oboInOwl:hasDbXref "FMA:76622" ; oboInOwl:hasSynonymType core:PENDING_REVIEW ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005253 ; owl:annotatedTarget "desmocranium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005254 ; owl:annotatedTarget "Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget _:genid140245 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget "Mesenchyme that is part of a developing toe [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget "hind limb digit mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget "foot digit mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget "finger ray mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005255 ; owl:annotatedTarget "pedal digital ray mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005256 ; owl:annotatedTarget _:genid140258 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005256 ; owl:annotatedTarget "Mesenchyme that is part of a developing trunk." . [] oboInOwl:hasDbXref "EHDAA2:0002092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005256 ; owl:annotatedTarget "trunk and cervical mesenchyme" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000955 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "Mesenchyme that is part of a developing finger [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "fore limb digit mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "hand digit mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "anterior limb digital ray mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "finger ray mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005257 ; owl:annotatedTarget "manual digital ray mesenchyme" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000955 ; owl:annotatedTarget "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005258 ; owl:annotatedTarget "Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005259 ; owl:annotatedTarget "Mesenchyme that is part of a developing lower leg [Automatically generated definition]." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005268 ; owl:annotatedTarget _:genid140287 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005268 ; owl:annotatedTarget "An artery that supplies the renal cortex." . [] oboInOwl:hasDbXref "MP:0011314" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005268 ; owl:annotatedTarget "kidney cortex artery" . [] oboInOwl:hasDbXref "MA:0002582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005268 ; owl:annotatedTarget "renal cortex artery" . [] oboInOwl:hasDbXref "MA:0002582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005268 ; owl:annotatedTarget "renal cortex arterial system" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005269 ; owl:annotatedTarget _:genid140298 . [] oboInOwl:hasDbXref "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005269 ; owl:annotatedTarget "Artery that receives blood from the renal cortex[MP, modified]." . [] oboInOwl:hasDbXref "MP:0011322" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005269 ; owl:annotatedTarget "kidney cortex vein" . [] oboInOwl:hasDbXref "MA:0002592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005269 ; owl:annotatedTarget "renal cortex venous system" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget _:genid140308 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget _:genid140310 . [] oboInOwl:hasDbXref "PMID:18575881" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget "A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells." . [] oboInOwl:source "PMID:18575881" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget "In the renal cortex, interstitial fibroblasts produce erythropoietin and are distinguished from other interstitial cells by their prominent F-actin cytoskeleton, abundance of rough endoplasmic reticulum, and by ecto-5'-nucleotidase expression in their plasma membrane. The resident dendritic cells belong to the mononuclear phagocyte system and fulfil a sentinel function. They are characterized by their expression of MHC class II and CD11c." . [] oboInOwl:hasDbXref "MA:0002608" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget "kidney cortex interstitium" . [] oboInOwl:hasDbXref "EMAPA:28136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005270 ; owl:annotatedTarget "cortical stroma" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005273 ; owl:annotatedTarget _:genid140318 . [] oboInOwl:hasDbXref "UBERON:gvg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005273 ; owl:annotatedTarget "Region of skin beneath the nail plate[WP]." . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "acide glutamique" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005276 ; owl:annotatedTarget "A dorsal skin of digit that is part of a manual digit." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005276 ; owl:annotatedTarget "this class is explicitly the union of the two FMA classes" . [] oboInOwl:hasDbXref "FMA:38320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005276 ; owl:annotatedTarget "skin of dorsal part of finger" . [] oboInOwl:hasDbXref "FMA:60346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005276 ; owl:annotatedTarget "subdivision of skin of dorsal part of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005277 ; owl:annotatedTarget "A dorsal skin of digit that is part of a pedal digit." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005277 ; owl:annotatedTarget "this class is explicitly the union of the two FMA classes" . [] oboInOwl:hasDbXref "FMA:37868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005277 ; owl:annotatedTarget "skin of dorsal part of toe" . [] oboInOwl:hasDbXref "FMA:60523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005277 ; owl:annotatedTarget "subdivision of skin of dorsal part of toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005278 ; owl:annotatedTarget "A nail bed that is part of a manual digit." . [] oboInOwl:hasDbXref "FMA:60348" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005278 ; owl:annotatedTarget "nail bed of finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005279 ; owl:annotatedTarget "A nail bed that is part of a pedal digit." . [] oboInOwl:hasDbXref "FMA:60529" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005279 ; owl:annotatedTarget "nail bed of toe" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget obo:UBERON_0000467 . [] oboInOwl:hasDbXref "Wikipedia:Ventricular_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP]." . [] oboInOwl:hasDbXref "EHDAA2:0004362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "CNS ventricular system" . [] oboInOwl:hasDbXref "ZFA:0001261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "ventricular system" . [] oboInOwl:hasDbXref "FMA:242675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "ventricular system of neuraxis" . [] oboInOwl:hasDbXref "Wikipedia:Ventricular_system" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "ventricle system" . [] oboInOwl:hasDbXref "Wikipedia:Ventricular_system" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005281 ; owl:annotatedTarget "ventriculi cerebri" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000005" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005282 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005282 ; owl:annotatedTarget "EMAPA:37447" . [] oboInOwl:hasDbXref "VHOG:0000005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005282 ; owl:annotatedTarget "brain ventricular system" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005283 ; owl:annotatedTarget _:genid140368 . [] oboInOwl:hasDbXref "ISBN:0471888893", "Wikipedia:Tela_chorioidea", "http://isc.temple.edu/neuroanatomy/lab/embryo_new/choroid/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005283 ; owl:annotatedTarget "A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm]." . [] oboInOwl:source "ZFA:0000447" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005283 ; owl:annotatedTarget "Portion of tissue that is part of the primitive meninx which forms a fold, roofing a ventricle of the brain and supporting the choroid plexus[ZFA:0000447]." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005283 ; owl:annotatedTarget "Note that the structure in ZFA may be different" . [] oboInOwl:hasDbXref "FMA:242849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005283 ; owl:annotatedTarget "tela chorioidea" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005286 ; owl:annotatedTarget "Tela choroidea that lines the tectal ventricle." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005157" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005286 ; owl:annotatedTarget "Tela chorioidea that lines the tectal ventricle.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0005157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005286 ; owl:annotatedTarget "tela chorioidea tectal ventricle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005286 ; owl:annotatedTarget "tela choroidea of cerebral aqueduct" . [] oboInOwl:hasDbXref "ZFA:0005157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005286 ; owl:annotatedTarget "tela choroidea tectal ventricle" . [] oboInOwl:hasDbXref "Wikipedia:Tela_chorioidea_of_fourth_ventricle", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005158" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "Tela chorioidea that lines the fourth ventricle.[TAO]" . [] oboInOwl:hasDbXref "FMA:78493", "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "tela choroidea" . [] oboInOwl:hasDbXref "FMA:78493" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "choroid membrane" . [] oboInOwl:hasDbXref "FMA:78493" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "choroid membrane of fourth ventricle" . [] oboInOwl:hasDbXref "FMA:78493", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "tela choroidea ventriculi quarti" . [] oboInOwl:hasDbXref "Wikipedia:Tela_chorioidea_of_fourth_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005287 ; owl:annotatedTarget "tela choroidea ventriculi quarti" . [] oboInOwl:hasDbXref "Wikipedia:Tela_chorioidea_of_third_ventricle", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "Tela chorioidea that lines the third ventricle[ZFA]. The part of the choroid plexus in relation to the body of the ventricle forms the vascular fringed margin of a triangular process of pia mater, named the tela chorioidea of the third ventricle, and projects from under cover of the lateral edge of the fornix. Blood is supplied by branches from the superior cerebellar artery[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005159" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "Tela chorioidea that lines the third ventricle.[TAO]" . [] oboInOwl:hasDbXref "FMA:78463" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "choroid membrane of third ventricle" . [] oboInOwl:hasDbXref "ZFA:0005159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "tela chorioidea third ventricle" . [] oboInOwl:hasDbXref "FMA:78463", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "tela choroidea ventriculi tertii" . [] oboInOwl:hasDbXref "Wikipedia:Tela_chorioidea_of_third_ventricle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005288 ; owl:annotatedTarget "tela choroidea ventriculi tertii" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005289 ; owl:annotatedTarget "Tela chorioidea that lines the telencephalic ventricle." . [] oboInOwl:hasDbXref "ZFA:0005160" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005289 ; owl:annotatedTarget "tela chorioidea telencephalic ventricle" . [] oboInOwl:hasDbXref "FMA:83712", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005289 ; owl:annotatedTarget "tela choroidea (ventriculi lateralis)" . [] oboInOwl:hasDbXref "FMA:83712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005289 ; owl:annotatedTarget "tela choroidea of lateral ventricle" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005290 ; owl:annotatedTarget _:genid140417 . [] oboInOwl:hasDbXref "BTO:0000758", "Wikipedia:Myelencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005290 ; owl:annotatedTarget "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000456" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/myelencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005290 ; owl:annotatedTarget "The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000456" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005290 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "DHBA:10662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005290 ; owl:annotatedTarget "myelencephalon (medulla oblongata)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005291 ; owl:annotatedTarget "A portion of tissue that is part of an embryo." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005291 ; owl:annotatedTarget "portion of embryonic tissue" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "acido glutamico" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005292 ; owl:annotatedTarget "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011411" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "The elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary." . [] oboInOwl:source "ncithesaurus:Urogenital_Ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "UMLS:C0231047" . [] oboInOwl:source "ncithesaurus:Gonadal_Ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "UMLS:C1512243" . [] oboInOwl:hasDbXref "MP:0011411", "Wikipedia:Gonadal_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "genital ridge" . [] oboInOwl:hasDbXref "Wikipedia:Gonadal_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "gonadal ridge" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "indifferent gonadal ridge" . [] oboInOwl:hasDbXref "Wikipedia:Gonadal_ridge" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "crista gonadalis" . [] oboInOwl:hasDbXref "MP:0011411" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005294 ; owl:annotatedTarget "genital cord" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005295 ; owl:annotatedTarget obo:UBERON_0005154 . [] oboInOwl:hasDbXref "Wikipedia:Sex_cords", "http://www.answers.com/topic/sex-cord" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005295 ; owl:annotatedTarget "Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female." . [] oboInOwl:source "ncithesaurus:Gonadal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005295 ; owl:annotatedTarget "UMLS:C1512242" . [] oboInOwl:hasDbXref "Wikipedia:Cortical_cords" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005296 ; owl:annotatedTarget "Structures that develop from sex cords in the female. After further development they become the ovarian follicles." . [] oboInOwl:source "ncithesaurus:Cortical_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005296 ; owl:annotatedTarget "UMLS:C1511527" . [] oboInOwl:hasDbXref "VHOG:0001339" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005296 ; owl:annotatedTarget "ovigerous cords" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005297 ; owl:annotatedTarget _:genid140463 . [] oboInOwl:hasDbXref "Wikipedia:Testis_cords" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005297 ; owl:annotatedTarget "The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP]." . [] oboInOwl:hasDbXref "MP:0006424" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005297 ; owl:annotatedTarget "testis cord" . [] oboInOwl:hasDbXref "EHDAA2:0002011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005297 ; owl:annotatedTarget "testis primary sex cords" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:20839338", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005298 ; owl:annotatedTarget "A zone of skin that is part of a clitoris [Automatically generated definition]." . [] oboInOwl:hasDbXref "Wikipedia:Clitoral_hood", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005299 ; owl:annotatedTarget "A retractable double-layered fold of skin and mucous membrane that covers the clitoral glans." . [] oboInOwl:source "ncithesaurus:Female_Prepuce" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005299 ; owl:annotatedTarget "UMLS:C0227771" . [] oboInOwl:hasDbXref "Wikipedia:Clitoral_hood" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005299 ; owl:annotatedTarget "clitoral hood" . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000956 ; owl:annotatedTarget "pro-B cell (Philadelphia nomenclature)" . [] oboInOwl:hasDbXref "EMAPA:30699" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005299 ; owl:annotatedTarget "prepuce of female" . [] oboInOwl:hasDbXref "Wikipedia:Clitoral_hood" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005299 ; owl:annotatedTarget "preputium clitoridis" . [] oboInOwl:hasDbXref "GO:0039019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005309 ; owl:annotatedTarget "A pronephric nephron is the functional unit of the pronephros[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011091" ; oboInOwl:ontology "AAO" ; oboInOwl:source "UBERON:0005309" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005309 ; owl:annotatedTarget "The structure that is the basic functional unit of the pronephros.[AAO]" . [] oboInOwl:source "GO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005310 ; owl:annotatedTarget _:genid140494 . [] oboInOwl:hasDbXref "GO:0039020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005310 ; owl:annotatedTarget "The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001558" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005310 ; owl:annotatedTarget "Bilaterally paired tubes connecting the pronephric glomeruli to the pronephric ducts. In zebrafish and other teleosts, the pronephric nephron and tubules form after the pronephric duct, connecting to the anterior-most tip of the pronephric ducts. Drummond, 2000.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005310 ; owl:annotatedTarget "pronephric tubule" . [] oboInOwl:hasDbXref "ZFA:0001558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005310 ; owl:annotatedTarget "ciliated neck segment" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005311 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:source "PMID:20484386" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005311 ; owl:annotatedTarget _:genid140501 . [] oboInOwl:source "Stedmans" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005311 ; owl:annotatedTarget _:genid140503 . [] oboInOwl:hasDbXref "GO:0060596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005311 ; owl:annotatedTarget "The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO]." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005316 ; owl:annotatedTarget "The endothelial lining of the endocardium." . [] oboInOwl:hasDbXref "FMA:83596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005316 ; owl:annotatedTarget "endocardium endothelium" . [] oboInOwl:hasDbXref "FMA:83596" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005316 ; owl:annotatedTarget "endothelium of endocardium" . [] oboInOwl:hasDbXref "GO:0061155" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005317 ; owl:annotatedTarget "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." . [] oboInOwl:hasDbXref "GO:0061155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005317 ; owl:annotatedTarget "pulmonary artery endothelial tube" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005319 ; owl:annotatedTarget _:genid140523 . [] oboInOwl:hasDbXref "GO:0061211" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005319 ; owl:annotatedTarget "The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO]." . [] oboInOwl:hasDbXref "GO:0061214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005321 ; owl:annotatedTarget "." . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005322 ; owl:annotatedTarget _:genid140535 . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "acidum glutamicum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005322 ; owl:annotatedTarget "A nephron that is part of a mesonephros." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010387" ; oboInOwl:ontology "AAO" ; oboInOwl:source "PMID:9268568" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005322 ; owl:annotatedTarget "The structure that is the basic functional unit of the kidney.[AAO]" . [] oboInOwl:hasDbXref "ZFA:0005592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005322 ; owl:annotatedTarget "stage IV nephron" . [] oboInOwl:hasDbXref "GO:0061219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005323 ; owl:annotatedTarget "Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO]." . [] oboInOwl:hasDbXref "GO:0061224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005325 ; owl:annotatedTarget "The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010388" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005325 ; owl:annotatedTarget "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001238" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0127224411 Vize PD, Woolf AS, Bard JBL, The kidney: From normal development to congenital disease (2003) p.3", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005325 ; owl:annotatedTarget "In animals in which the mesonephros is the terminal kidney, such as amphibians and fish, the final organ is very complex, containing a large number of nephrons, most of which have an internal glomerulus.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005325 ; owl:annotatedTarget "XAO/AAO class belongs here, as it refers to mesonephric structure" . [] oboInOwl:hasDbXref "AAO:0010388" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005325 ; owl:annotatedTarget "glomerulus" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005326 ; owl:annotatedTarget _:genid140558 . [] oboInOwl:hasDbXref "GO:0061231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005326 ; owl:annotatedTarget "The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO]." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005327 ; owl:annotatedTarget _:genid140565 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005327 ; owl:annotatedTarget _:genid140567 . [] oboInOwl:hasDbXref "GO:0061232" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005327 ; owl:annotatedTarget "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO]." . [] oboInOwl:hasDbXref "GO:0061236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005328 ; owl:annotatedTarget "The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005330 ; owl:annotatedTarget _:genid140579 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget obo:CL_0000955 . [] oboInOwl:hasDbXref "GO:0061241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005330 ; owl:annotatedTarget "The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO]." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005331 ; owl:annotatedTarget _:genid140586 . [] oboInOwl:hasDbXref "GO:0061243" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005331 ; owl:annotatedTarget "The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." . [] oboInOwl:hasDbXref "GO:0061244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005332 ; owl:annotatedTarget "The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005333 ; owl:annotatedTarget "A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland." . [] oboInOwl:source "http://medical-dictionary.thefreedictionary.com/mammary+bud" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0005333 ; owl:annotatedTarget "produced along the length of the embryonic mammary ridge these buds represent the future locations of the mammary glands. Invagination of ectoderm at each bud leads to the development of epithelial diverticula, later maturing as lactiferous ducts" . [] oboInOwl:hasDbXref "GO:0060648" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005333 ; owl:annotatedTarget "mammary gland bud" . [] oboInOwl:hasDbXref "PMID:11244048" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000957 ; owl:annotatedTarget "large pre-B cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005334 ; owl:annotatedTarget "A lamina propria that is part of a mucosa of oral region." . [] oboInOwl:hasDbXref "Wikipedia:Ventricular_outflow_tract" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005337 ; owl:annotatedTarget "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." . [] oboInOwl:hasDbXref "MP:0010224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005337 ; owl:annotatedTarget "heart ventricle outflow tract" . [] oboInOwl:hasDbXref "Wikipedia:Ventricular_outflow_tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005337 ; owl:annotatedTarget "ventricular outflow tract" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005338 ; owl:annotatedTarget "An outflow tract that is part of a aorta." . [] oboInOwl:hasDbXref "MP:0008219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005340 ; owl:annotatedTarget "A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005340 ; owl:annotatedTarget "EMAPA:37844" . [] oboInOwl:hasDbXref "MP:0008219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005340 ; owl:annotatedTarget "dorsal commissure" . [] oboInOwl:hasDbXref "MP:0008220" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005341 ; owl:annotatedTarget "The fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures[MP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005341 ; owl:annotatedTarget "EMAPA:37845" . [] oboInOwl:source "NCBIBook:NBK10047" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget _:genid140627 . [] oboInOwl:hasDbXref "MP:0008439", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget "The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP]." . [] oboInOwl:hasDbXref "BRAINSPAN:BRAINSPAN" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget "CP" . [] oboInOwl:hasDbXref "PMID:23375746" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget "CxP" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget "future cortical layers II-VI" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005343 ; owl:annotatedTarget "future neocortex" . [] oboInOwl:hasDbXref "MP:0010145", "Wikipedia:Spermatic_cord" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005352 ; owl:annotatedTarget "The cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis[MP]." . [] oboInOwl:source "ncithesaurus:Spermatic_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005352 ; owl:annotatedTarget "UMLS:C0037855" . [] oboInOwl:hasDbXref "Wikipedia:Spermatic_cord" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005352 ; owl:annotatedTarget "funiculus spermaticus" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005358 ; owl:annotatedTarget "A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord." . [] oboInOwl:hasDbXref "EMAPA:35209" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005358 ; owl:annotatedTarget "ventricular layer" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16015 ; owl:annotatedTarget "glutamic acid" . [] oboInOwl:hasDbXref "FMA:242770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005358 ; owl:annotatedTarget "region of wall of ventricular system of neuraxis" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget obo:UBERON_0009127 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "The group of sensory neuron cell bodies associated with the vagus nerve." . [] oboInOwl:hasDbXref "ZFA:0007067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "gX" . [] oboInOwl:hasDbXref "FMA:53472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "ganglion of vagus nerve" . [] oboInOwl:hasDbXref "FMA:53472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "right glossopharyngeal ganglion" . [] oboInOwl:hasDbXref "ZFA:0007067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "vagal ganglion" . [] oboInOwl:hasDbXref "FMA:53472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "vagus neural ganglion" . [] oboInOwl:hasDbXref "EMAPA:16798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005362 ; owl:annotatedTarget "vagus X" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget _:genid140656 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget _:genid140658 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0001087", "PMID:9362461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "The large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000685" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "EMAPA:17155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "inferior vagus X" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "ganglion inferius (nervus vagus)" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_ganglion_of_vagus_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "ganglion inferius nervi vagi" . [] oboInOwl:hasDbXref "FMA:6230", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "ganglion inferius nervus vagi" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_ganglion_of_vagus_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "ganglion nodosum" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "inferior ganglion of vagus" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "inferior ganglion of vagus nerve" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "nodose ganglion" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "tenth cranial nerve nodose ganglion" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "vagus nerve inferior ganglion" . [] oboInOwl:hasDbXref "FMA:6230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "vagus nerve nodose ganglion" . [] oboInOwl:hasDbXref "EMAPA:17155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "inferior vagus ganglion" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "nodose ganglia" . [] oboInOwl:hasDbXref "VHOG:0000685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005363 ; owl:annotatedTarget "vagus X inferior ganglion" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005366 ; owl:annotatedTarget "The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions." . [] oboInOwl:source "XAO:0004180" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005366 ; owl:annotatedTarget "Part of the telencephalon, comprised of paired anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits. In Xenopus,the olfactory bulbs begin to fuse at NF stage 50, fusion is complete around NF stage 58. The cerebral vein loops around the olfactory bulb by NF stage 43[XAO:0004180]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000833" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1753-4887.2004.tb00097.x Buck LB, Olfactory receptors and odor coding in mammals. Nutrition Reviews (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005366 ; owl:annotatedTarget "(In mammals) Odorant detection is mediated by millions of olfactory sensory neurons located in the olfactory epithelium lining the nasal cavity. These neurons transmit sensory signals to the olfactory bulb of the brain, which in turn sends signals to the olfactory cortex.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Olfactory_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005366 ; owl:annotatedTarget "UMLS:C0178780" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget _:genid140686 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget obo:UBERON_0005375 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "ISBN:0940780577", "MP:0009677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001623" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/posterior+column+of+spinal+cord" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "The dorsolateral ridge of gray matter in each lateral half of the spinal cord. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Posterior_Column" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "UMLS:C0458459" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_column" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "posterior column" . [] oboInOwl:hasDbXref "BAMS:dc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "dorsal column system" . [] oboInOwl:hasDbXref "BAMS:dc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005373 ; owl:annotatedTarget "dorsal columns" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0009679" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005375 ; owl:annotatedTarget "The area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001622" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/anterior+column+of+spinal+cord" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005375 ; owl:annotatedTarget "The ventral ridge of gray matter in each half of the spinal cord. [TFD][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005375 ; owl:annotatedTarget "in MA, this is a subclass of white matter, but in WP/Gray's, the anterior column is a synonym of the grey matter section. is this the same as funiculus? See lateral column." . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget _:genid140701 . [] oboInOwl:hasDbXref "NLXANAT:1010001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't." . [] oboInOwl:source "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum" . [] oboInOwl:source "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (putamen and the globus pallidus) and the caudate nucleus" . [] oboInOwl:source "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "It may also refer to both the basal ganglia and the internal capsule collectively." . [] oboInOwl:source "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "It may also refer to the putamen and caudate collectively." . [] oboInOwl:source "neuronames:2340" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance." . [] oboInOwl:hasDbXref "ABA:STRd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "striatum dorsal region" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "caudoputamen" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "corpus striatum" . [] oboInOwl:hasDbXref "BTO:0004701" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "dorsal basal ganglia" . [] oboInOwl:hasDbXref "BTO:0004701" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "dorsal basal ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_striatum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "striated body" . [] oboInOwl:hasDbXref "BTO:0004701" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005382 ; owl:annotatedTarget "striatum dorsale" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget _:genid140718 . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure." . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudateputamen" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudoputamen" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudate putamen" . [] oboInOwl:hasDbXref "BAMS:CPu" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudate putamen (striatum)" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudate-putamen" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "caudateputamen" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "dorsal striatum" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "neostriatum" . [] oboInOwl:hasDbXref "NLXANAT:100312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005383 ; owl:annotatedTarget "striatum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000958 ; owl:annotatedTarget obo:CL_0000818 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005384 ; owl:annotatedTarget "An epithelium that lines the nasal cavity." . [] oboInOwl:source "ncithesaurus:Nasal_Cavity_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005384 ; owl:annotatedTarget "UMLS:C1709151" . [] oboInOwl:hasDbXref "FMA:63140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005384 ; owl:annotatedTarget "nasal epithelium" . [] oboInOwl:hasDbXref "MA:0001324" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005384 ; owl:annotatedTarget "nasal mucosa" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000958 ; owl:annotatedTarget "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005388 ; owl:annotatedTarget "An array of photoreceptors and any supporting cells found in an eye." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005389 ; owl:annotatedTarget "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget obo:UBERON_0004573 . [] oboInOwl:hasDbXref "Wikipedia:Carotid_artery", "https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "One of: the common carotid artery, or its branches, the external and internal carotid arteries." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000097" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO]" . [] oboInOwl:source "ncithesaurus:Carotid_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "UMLS:C0007272" . [] oboInOwl:hasDbXref "AAO:0010217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "carotid" . [] oboInOwl:hasDbXref "MA:0001925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "carotid artery" . [] oboInOwl:hasDbXref "FMA:70504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "subdivision of common carotid artery" . [] oboInOwl:hasDbXref "FMA:70504" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005396 ; owl:annotatedTarget "common carotid arterial subdivision" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "An arachnoid mater that surrounds a brain." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000230" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/arachnoid+mater" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "The middle membrane of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000230" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "FMA:83981", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "arachnoidea mater cranialis" . [] oboInOwl:hasDbXref "FMA:83981", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "arachnoidea mater encephali" . [] oboInOwl:hasDbXref "MA:0000814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "brain arachnoid matter" . [] oboInOwl:hasDbXref "FMA:83981" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005397 ; owl:annotatedTarget "cranial arachnoid mater" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005398 ; owl:annotatedTarget "A sex gland that is part of a female reproductive system." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005399 ; owl:annotatedTarget "A sex gland that is part of a male reproductive system." . [] oboInOwl:hasDbXref "EMAPA:19285" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005399 ; owl:annotatedTarget "accessory sex gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005400 ; owl:annotatedTarget "An arachnoid mater that is part of a telencephalon." . [] oboInOwl:hasDbXref "MA:0000980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005400 ; owl:annotatedTarget "telencephalon arachnoid matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005401 ; owl:annotatedTarget "A gray matter that is part of a cerebral hemisphere." . [] oboInOwl:external_ontology "BTO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005401 ; owl:annotatedTarget "BTO may actually be a more generic structure; FMA may represent a more specific structure. Consider merging with gray matter of telencephalon" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005401 ; owl:annotatedTarget "EMAPA:37477" . [] oboInOwl:hasDbXref "BTO:0000823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005401 ; owl:annotatedTarget "cerebral gray matter" . [] oboInOwl:hasDbXref "MA:0000944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005401 ; owl:annotatedTarget "cerebral grey matter" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget obo:UBERON_0006846 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget _:genid140804 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget _:genid140807 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0012256", "Wikipedia:Philtrum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget "The vertical groove found on the median line of the upper lip, extending to the nose." . [] oboInOwl:hasDbXref "MA:0001577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget "lip philtrum" . [] oboInOwl:hasDbXref "Wikipedia:Philtrum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget "infranasal depression" . [] oboInOwl:hasDbXref "Wikipedia:Philtrum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget "medial cleft" . [] oboInOwl:hasDbXref "FMA:59819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005402 ; owl:annotatedTarget "philtral region of upper lip" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005403 ; owl:annotatedTarget _:genid140815 . [] oboInOwl:hasDbXref "NLX:57107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005403 ; owl:annotatedTarget "A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info)." . [] oboInOwl:source "neuronames:2341" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005403 ; owl:annotatedTarget "The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 )." . [] oboInOwl:hasDbXref "ABA:STRv" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005403 ; owl:annotatedTarget "striatum ventral region" . [] oboInOwl:hasDbXref "BTO:0004702" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005403 ; owl:annotatedTarget "striatum ventrale" . [] oboInOwl:hasDbXref "GO:0097095", "PMID:12416537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005404 ; owl:annotatedTarget "A suture between frontal and nasal bones." . [] oboInOwl:hasDbXref "FMA:52948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005404 ; owl:annotatedTarget "frontonasal suture of skull" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005407 ; owl:annotatedTarget _:genid140834 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005407 ; owl:annotatedTarget "The small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland." . [] oboInOwl:hasDbXref "MP:0013562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005408 ; owl:annotatedTarget "Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow." . [] oboInOwl:hasDbXref "NLXANAT:20090312" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005408 ; owl:annotatedTarget "CVO" . [] oboInOwl:hasDbXref "NLXANAT:20090312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005408 ; owl:annotatedTarget "circumventricular organ" . [] oboInOwl:hasDbXref "FMA:84081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005408 ; owl:annotatedTarget "circumventricular organ of neuraxis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "The part of the digestive system that excludes the hepatobiliary system." . [] oboInOwl:source "ncithesaurus:Gastrointestinal_System" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000412" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0721676685 Sherwood Romer A and Parsons T, Vertebrate body (1977) p.3", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG]" . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla." . [] oboInOwl:source "ncithesaurus:Gastrointestinal_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "UMLS:C0012240" . [] oboInOwl:hasDbXref "GAID:294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "GI tract" . [] oboInOwl:hasDbXref "MA:0000323" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "alimentary system" . [] oboInOwl:hasDbXref "MA:0000323" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "alimentary tract" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16024 ; owl:annotatedTarget "D-manno-hexose" . [] oboInOwl:hasDbXref "FMA:71132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "gastro-intestinal system" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "gastroenterological system" . [] oboInOwl:hasDbXref "GAID:294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "gastrointestinal (GI) tract" . [] oboInOwl:hasDbXref "FMA:71132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "gastrointestinal system" . [] oboInOwl:hasDbXref "FMA:71132" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005409 ; owl:annotatedTarget "gastrointestinal tract" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget _:genid140861 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "An otic capsule endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001500" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "Bilaterally paired cartilage encasing the semicircular canals of the inner ear.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001500" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: develops_from neurocranium (UBERON:0001703)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001500" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: part_of neurocranium (UBERON:0001703)[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "EMAPA:37467" . [] oboInOwl:hasDbXref "ZFA:0001500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005410 ; owl:annotatedTarget "auditory capsule" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005411 ; owl:annotatedTarget _:genid140873 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005411 ; owl:annotatedTarget "The cartilage or bony capsule surrounding the inner ear mechanism." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005411 ; owl:annotatedTarget "EMAPA:37466" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget obo:UBERON_0006846 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget _:genid140879 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget _:genid140881 . [] oboInOwl:hasDbXref "Wikipedia:Choroid_fissure", "ZFA:0001284", "http://medical-dictionary.thefreedictionary.com/optic+fissure", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3083162&group_id=36855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011026" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0815318960" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "A break in the continuity of the optic cup where the two sides of the cup meet.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000655" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "The folded arrangement of the vertebrate retina and RPE [retinal pigment epithelial] provides an evolutionary explanation for the occurrence of the choroid fissure, as proposed more than a century ago. Early in evolution, before the optic cup invaginated, the axons from retinal ganglion cells would simply have run over the surface of the structure. Hence, one can view the optic nerve as having acted rather like a rope in linking the retina to higher centres: the developing eye cup has simply wrapped around this 'rope', and the developing axons have thereby not needed to penetrate the retina.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000655" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "choroid fissure - optic fissure" . [] oboInOwl:hasDbXref "ZFA:0001284" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "optic fissures" . [] oboInOwl:hasDbXref "EHDAA2:0001319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "optic stalk fissure" . [] oboInOwl:hasDbXref "MA:0001305", "XAO:0000474", "ZFA:0001284" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "choroid fissure" . [] oboInOwl:hasDbXref "XAO:0000474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005412 ; owl:annotatedTarget "ventral choroidal fissure" . [] oboInOwl:hasDbXref "NLXANAT:1005036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005413 ; owl:annotatedTarget "This tract conveys interoceptive, proprioceptive, and exteroceptive information from the body's internal organs, and from the trunk, extremities, and neck region to the Cerebellum." . [] oboInOwl:source "Wikipedia:Spinocerebellar_tract" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005413 ; owl:annotatedTarget "The spinocerebellar tract is a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. This tract conveys information to the cerebellum about limb and joint position[Wikipedia:Spinocerebellar_tract]." . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0005417 ; owl:annotatedTarget obo:UBERON_0005418 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005417 ; owl:annotatedTarget "A limb bud that develops into a forelimb." . [] oboInOwl:hasDbXref "MIAA:0000065" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005417 ; owl:annotatedTarget "limb bud - forelimb" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0003198" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005417 ; owl:annotatedTarget "upper limb bud" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005417 ; owl:annotatedTarget "wing bud" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005418 ; owl:annotatedTarget "A limb bud that develops into a hindlimb." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010382" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005418 ; owl:annotatedTarget "The bilateral thickening of the ectoderm in the region of the first noticeable at NF stage 47, and innervated by NF stage 51. The hind limb buds develop before the forelimb buds.[AAO]" . [] oboInOwl:hasDbXref "XAO:0003066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005418 ; owl:annotatedTarget "hind limb bud" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000959 ; owl:annotatedTarget obo:CL_0000818 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "A limb bud that develops into a forelimb or pectoral fin." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000141" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "Fin bud that develops into the pectoral fin.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001754" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jmor.10264 Davis MC, Shubin NH, Force A, Pectoral fin and girdle development in the basal actinopterygians Polyodon spathula and Acipenser transmontanus. Journal of Morphology (2004)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001754" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "forelimb - pectoral fin bud" . [] oboInOwl:hasDbXref "TAO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "pectoral fin bud" . [] oboInOwl:hasDbXref "TAO:0000141" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005419 ; owl:annotatedTarget "pectoral fin buds" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000959 ; owl:annotatedTarget "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." . _:genid139575 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003382, obo:UBERON_0005730 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "A limb bud that develops into a hindlimb or pelvic fin." . [] oboInOwl:source "PMID:15893975" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget obo:NCBITaxon_31033 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001384" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "Fin bud that develops into the pelvic fin.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001260" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "hindlimb/pelvic fin bud" . [] oboInOwl:hasDbXref "TAO:0001384" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "pelvic fin bud" . _:genid139582 oboInOwl:hasDbXref "ZFA:0001384" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005420 ; owl:annotatedTarget "pelvic fin buds" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003381 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget _:genid140943 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "An apical ectodermal ridge that is part of a pectoral appendage bud." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001064" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "An ectodermal thickening at the end of the forelimb bud in the developing embryo. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000085" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "Apical ectodermal ridge that is part of the pectoral fin bud.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001064" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1440-169X.2007.00942.x", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "AER forelimb" . [] oboInOwl:hasDbXref "VHOG:0001064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "apical ectodermal ridge forelimb" . [] oboInOwl:hasDbXref "ZFA:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "apical ectodermal ridge pectoral fin bud" . [] oboInOwl:hasDbXref "EHDAA2:0000138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "upper limb bud apical ectodermal ridge" . [] oboInOwl:hasDbXref "Giesha:syn" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "wing AER" . _:genid139597 oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "wing apical ectodermal ridge" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007288 . [] oboInOwl:hasDbXref "TAO:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "aer pectoral fin" . [] oboInOwl:hasDbXref "TAO:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "apical ectodermal ridge pectoral fin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16024 ; owl:annotatedTarget "D-mannose" . [] oboInOwl:hasDbXref "TAO:0000085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005421 ; owl:annotatedTarget "apical fold pectoral fin" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget _:genid140962 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "An apical ectodermal ridge that is part of a pelvic appendage bud." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001066" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "An ectodermal thickening at the end of the hindlimb bud in the developing embryo. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001385" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZIFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "Apical ectodermal ridge that is part of the pelvic fin bud.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001066" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1440-169X.2007.00942.x", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "apical ectodermal ridge hind limb" . [] oboInOwl:hasDbXref "VHOG:0001066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "apical ectodermal ridge hindlimb" . [] oboInOwl:hasDbXref "EHDAA2:0003194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "lower lmb bud apical ectodermal ridge" . [] oboInOwl:hasDbXref "VHOG:0001066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "AER hindlimb" . [] oboInOwl:hasDbXref "TAO:0001385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005422 ; owl:annotatedTarget "apical ectodermal ridge pelvic fin bud" . [] oboInOwl:hasDbXref "MIAA:0000019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005423 ; owl:annotatedTarget "developmental tissue" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000492" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001306" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "optic cup outer layer" . [] oboInOwl:hasDbXref "ZFA:0000064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "outer layer optic cup" . [] oboInOwl:hasDbXref "ZFA:0000064" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "presumptive pigmented epithelia" . [] oboInOwl:hasDbXref "EMAPA:16677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "future PRE" . [] oboInOwl:hasDbXref "EMAPA:16677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "future pigmented layer" . [] oboInOwl:hasDbXref "EMAPA:16677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "future pigmented retinal epithelium" . [] oboInOwl:hasDbXref "TAO:0000064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005424 ; owl:annotatedTarget "presumptive pigmented epithelium" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "Portion of tissue that is the inner layer of the optic cup and will become the neural retina." . _:genid139637 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000490" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011272 . [] oboInOwl:hasDbXref "ZFA:0001071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "inner layer optic cup" . [] oboInOwl:hasDbXref "EHDAA2:0001304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "optic cup inner layer" . [] oboInOwl:hasDbXref "ZFA:0001071" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "presumptive retinas" . [] oboInOwl:hasDbXref "EMAPA:16675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "future neural epithelium" . [] oboInOwl:hasDbXref "EMAPA:16675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "future neural layer" . [] oboInOwl:hasDbXref "TAO:0001071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005425 ; owl:annotatedTarget "presumptive retina" . [] oboInOwl:hasDbXref "ZFIN:curator", "https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "Portion of tissue that gives rise to the lens." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001163" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/lens+vesicle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001163" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "hollow lens vesicle" . _:genid139650 oboInOwl:hasDbXref "ZFA:0001679" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "solid lens vesicle" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0004362 . [] oboInOwl:hasDbXref "ZFA:0001679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "immature lens" . [] oboInOwl:hasDbXref "ZFA:0001679", "ZFIN:ZDB-PUB-091023-49" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "lens mass" . [] oboInOwl:hasDbXref "ZFA:0001679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005426 ; owl:annotatedTarget "presumptive lens" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005427 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005427 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005427 ; owl:annotatedTarget _:genid141014 . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-061010-3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005427 ; owl:annotatedTarget "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000818" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001208" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:source "filemaps.com" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "In chicken fate mapping studies it was found to originate from neural crest residing between Somite 1-7 (S1-7); In mouse it is considered to be derived from rhombencephalic (post otic) neural crest cells and trunk neural crest cells (anterior to S5)" . [] oboInOwl:hasDbXref "XAO:0004191" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "VNC" . _:genid139665 oboInOwl:hasDbXref "ZFA:0000818" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005428 ; owl:annotatedTarget "post-otic neural crest" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011272 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005430 ; owl:annotatedTarget _:genid141027 . [] oboInOwl:hasDbXref "Wikipedia:Ansa_cervicalis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005430 ; owl:annotatedTarget "A loop of nerves that are part of the cervical plexus that lies superficial to the internal jugular vein in the carotid sheath. Branches from the ansa cervicalis innervate three of the four infrahyoid muscles, including the sternohyoid muscle, the sternothyroid muscle, and the omohyoid muscle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000961 ; owl:annotatedTarget obo:CL_0000843 . [] oboInOwl:hasDbXref "Wikipedia:Ansa_cervicalis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005430 ; owl:annotatedTarget "ansa cervicalis" . [] oboInOwl:hasDbXref "Wikipedia:Ansa_cervicalis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005430 ; owl:annotatedTarget "ansa hypoglossi" . _:genid139673 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004145, obo:UBERON_0011272 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005432 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005432 ; owl:annotatedTarget _:genid141035 . [] oboInOwl:hasDbXref "MP:0012510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005432 ; owl:annotatedTarget "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates." . [] oboInOwl:source "http://medical-dictionary.thefreedictionary.com/aortic+sac" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005432 ; owl:annotatedTarget "the merged ventral aortae of the embryo which supplies blood to the aortic arches[TMD][http://medical-dictionary.thefreedictionary.com/aortic+sac]." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005432 ; owl:annotatedTarget "saccus aorticus" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000961 ; owl:annotatedTarget "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." . [] oboInOwl:hasDbXref "FMA:24219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005434 ; owl:annotatedTarget "cervical region" . [] oboInOwl:hasDbXref "FMA:24219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005434 ; owl:annotatedTarget "neck subdivision" . [] oboInOwl:hasDbXref "FMA:24219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005434 ; owl:annotatedTarget "region of neck" . [] oboInOwl:hasDbXref "FMA:24219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005434 ; owl:annotatedTarget "subdivision of neck" . _:genid139684 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001640, obo:UBERON_0007687 . [] oboInOwl:hasDbXref "Wikipedia:Common_hepatic_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005436 ; owl:annotatedTarget "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005436 ; owl:annotatedTarget "EMAPA:37206" . [] oboInOwl:hasDbXref "Wikipedia:Common_hepatic_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005436 ; owl:annotatedTarget "arteria hepatica communis" . [] oboInOwl:hasDbXref "Wikipedia:Common_hepatic_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005436 ; owl:annotatedTarget "common hepatic" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005438 ; owl:annotatedTarget "The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0005438 ; owl:annotatedTarget "The sinus, before entering the auricle, is considerably dilated - nearly to the size of the end of the little finger. Its wall is partly muscular, and at its junction with the great coronary vein is somewhat constricted and furnished with a valve consisting of two unequal segments" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005438 ; owl:annotatedTarget "EMAPA:37836" . [] oboInOwl:source "ncithesaurus:Coronary_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005438 ; owl:annotatedTarget "UMLS:C0456944" . [] oboInOwl:hasDbXref "Wikipedia:Coronary_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005438 ; owl:annotatedTarget "sinus coronarius" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "halide ions" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget _:genid141059 . [] oboInOwl:notes "left branch" ; oboInOwl:source "embryology.ch" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget _:genid141065 . [] oboInOwl:hasDbXref "MESH:A07.541.278.395", "MP:0010564", "Wikipedia:Ductus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "A fetal blood vessel connecting the pulmonary artery with the descending aorta[MESH]. In the developing fetus, the ductus arteriosus is a shunt connecting the pulmonary artery to the aortic arch. It allows most of the blood from the right ventricle to bypass the fetus' fluid-filled lungs, protecting the lungs from being overworked and allowing the left ventricle to strengthen. There are two other fetal shunts, the ductus venosus and the foramen ovale[MP]. the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000923" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/ductus+arteriosus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "The temporary channel or blood vessel between the aorta and pulmonary artery in the fetus. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000923" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Ductus_Arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "UMLS:C0013273" . [] oboInOwl:hasDbXref "MP:0010564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "ductus Botallo" . [] oboInOwl:hasDbXref "Wikipedia:Ductus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "Botallo's duct" . [] oboInOwl:hasDbXref "MP:0010564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "arterial canal" . [] oboInOwl:hasDbXref "MP:0010564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "arterial duct" . [] oboInOwl:hasDbXref "Wikipedia:Ductus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "ductus arteriosis" . _:genid139713 oboInOwl:hasDbXref "Wikipedia:Ductus_arteriosus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "ductus arteriosum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003220 . [] oboInOwl:hasDbXref "Wikipedia:Ductus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "ductus botalli" . _:genid139715 oboInOwl:hasDbXref "Wikipedia:Ductus_arteriosus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "ductus layton" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010535 . [] oboInOwl:hasDbXref "MP:0010564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005440 ; owl:annotatedTarget "fetal ductus arteriosus" . _:genid139724 oboInOwl:notes "lower 6 intercostal nerve + subcostal nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget _:genid141086 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010531 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget _:genid141089 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget _:genid141091 . [] oboInOwl:hasDbXref "ISBN:9781435464339", "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "The lateral abdominal wall muscle that is the most superficial, immediately superficial to the internal oblique." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000788" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.193", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:External_Oblique_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "UMLS:C0224375" . _:genid139730 oboInOwl:hasDbXref "VHOG:0000788" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "abdominal external oblique muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004737 . [] oboInOwl:hasDbXref "FMA:13335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external abdominal oblique muscle" . _:genid139732 oboInOwl:hasDbXref "FMA:13335" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010533 . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique muscle" . [] oboInOwl:hasDbXref "MA:0002345" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "obliquus externus abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external abdominal oblique" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external abdominal oblique muscle" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique abdominal muscles" . _:genid139739 oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique abdominis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004736 . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "external oblique abdominis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "m. obliquus externus abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "oblique strength" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "obliquus abdominis externus" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "obliquus externus" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "obliquus externus abdominis" . _:genid139746 oboInOwl:hasDbXref "Wikipedia:Abdominal_external_oblique_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005442 ; owl:annotatedTarget "obliquus externus abdominis muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "A segment of autopod that is part of a pes." . [] oboInOwl:hasDbXref "FMA:24993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "foot region" . _:genid139753 oboInOwl:hasDbXref "FMA:24993" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "foot subdivision" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004736 . [] oboInOwl:hasDbXref "FMA:24993", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "regio pedis" . _:genid139755 oboInOwl:hasDbXref "FMA:24993" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "segment of foot" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:hasDbXref "FMA:24993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005445 ; owl:annotatedTarget "subdivision of foot" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Foramen_rotundum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa." . _:genid139764 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001543" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "A circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.vity. [Wikipedia:Foramen_rotundum][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001543" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:1018003 Presley R, Steel FLD, On the homology of the alisphenoid. Journal of Anatomy (1976)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "It is suggested that the mammalian lamina ascendens arose from an upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts, separating foramen rotundum from foramen ovale.[well established][VHOG]" . _:genid139766 oboInOwl:external_ontology "AAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "todo - check placement of AAO class" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005133 . [] oboInOwl:hasDbXref "Wikipedia:Foramen_rotundum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "foramen rotundum of the skull" . [] oboInOwl:hasDbXref "Wikipedia:Foramen_rotundum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "foramen rotundum ossis sphenoidalis" . [] oboInOwl:hasDbXref "VHOG:0001543" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005446 ; owl:annotatedTarget "round foramen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "A segment of autopod that is part of a manus." . [] oboInOwl:hasDbXref "FMA:24945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "hand region" . [] oboInOwl:hasDbXref "FMA:24945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "hand subdivision" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "regio manus" . _:genid139778 oboInOwl:hasDbXref "FMA:24945" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "segment of hand" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004736 . [] oboInOwl:hasDbXref "FMA:24945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005451 ; owl:annotatedTarget "subdivision of hand" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000962 ; owl:annotatedTarget obo:CL_0000843 . _:genid139780 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006635 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0005442 ] [ a owl:Restriction ; owl:onProperty obo:BSPO_0015014 ; owl:someValuesFrom obo:UBERON_0001221 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:notes "Inguinal ligament Iliac crest and the Lumbodorsal fascia." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget _:genid141154 . [] oboInOwl:notes "Linea alba Xiphoid process and the inferior ribs." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget _:genid141156 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000962 ; owl:annotatedTarget "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." . [] oboInOwl:notes "Linea alba Xiphoid process and the inferior ribs." ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget _:genid141158 . [] oboInOwl:hasDbXref "ISBN:9781435464339", "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "The lateral abdominal wall muscle that is deep to the external oblique and superficial to the transversus." . _:genid139792 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000789" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.193", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "Behind the thorax, the lateral group (of muscles in reptiles and mammals) remains essentially as for amphibians. (It breaks into three sheet-like layers: external oblique muscle, the internal oblique, and the transversus). More anteriorly, however, the ribs, now enlarged, penetrate and alter this group of muscles. The transversus is excluded from the thorax and the external and internal obliques become, respectively, the external and internal intercostal muscles, which contribute to the new function of ventilation of the lungs.[well established][VHOG]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:source "ncithesaurus:Internal_Oblique_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "UMLS:C1512878" . _:genid139794 oboInOwl:hasDbXref "VHOG:0000789" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "abdominal internal oblique muscle" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003220 . [] oboInOwl:hasDbXref "FMA:13891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal oblique" . [] oboInOwl:hasDbXref "MA:0002346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliquus internus abdominis" . [] oboInOwl:hasDbXref "FMA:13891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliquus internus abdominis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "abdominal internal oblique" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal abdominal oblique" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "HX" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal abdominal oblique muscle" . _:genid139801 oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal oblique abdominal" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005113 . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal oblique abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal oblique abdominis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "internal oblique muscle" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "musculus obliquus internus abdominis" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliqui internus" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliquus internus" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliquus internus abdominis" . _:genid139809 oboInOwl:hasDbXref "Wikipedia:Abdominal_internal_oblique_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005454 ; owl:annotatedTarget "obliquus internus abdominis muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005110 . [] oboInOwl:hasDbXref "Wikipedia:Jugular_foramen" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000249" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "Large foramen that houses the glossopharyngeal and vagus nerves and is located inside the condyloid fossa.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001113" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/jugular+foramen" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "One of a pair of openings between the lateral part of the occipital bone and the petrous part of the temporal bones in the skull. The foramen contains the inferior petrosal sinus; the transverse sinus; some meningeal branches of the occipital and ascending pharyngeal arteries; and the glossopharyngeal, vagus, and accessory nerves. [Free_Online_Medical_Dictionary]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000249" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "relationship loss: subclass braincase and otic capsule opening (AAO:0000051)[AAO]" . [] oboInOwl:source "ncithesaurus:Jugular_Foramen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "UMLS:C0222712" . [] oboInOwl:hasDbXref "FMA:56432" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "Posterior lacerate foramen" . [] oboInOwl:hasDbXref "Wikipedia:Jugular_foramen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005456 ; owl:annotatedTarget "foramen jugulare" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005457 ; owl:annotatedTarget "A thymus lobe that is in the left side of a thymus." . [] oboInOwl:hasDbXref "FMA:71195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005457 ; owl:annotatedTarget "left lobe of thymus" . [] oboInOwl:hasDbXref "FMA:71195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005457 ; owl:annotatedTarget "left thymic lobe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005460 ; owl:annotatedTarget "A vitelline vein that is in the left side of a multicellular organism." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141214 . [] oboInOwl:source "Kardong" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141216 . [] oboInOwl:notes "cervical nerve and dorsal scapular nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141218 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141220 . [] oboInOwl:notes "Posterior tubercles of transverse processes of C1 - C4 vertebrae" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141222 . [] oboInOwl:notes "Superior part of medial border of scapula" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget _:genid141224 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "An axial muscle that originates in the cervical vertebraae inserts on the scapula." . [] oboInOwl:hasDbXref "FMA:32519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "levator scapulae" . [] oboInOwl:hasDbXref "Wikipedia:Levator_scapulae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "levator scapula" . [] oboInOwl:hasDbXref "Wikipedia:Levator_scapulae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "levator scapulae muscle" . [] oboInOwl:hasDbXref "Wikipedia:Levator_scapulae_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "levator scapulæ" . [] oboInOwl:hasDbXref "Wikipedia:Levator_scapulae_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005461 ; owl:annotatedTarget "musculus levator scapulae" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget _:genid141233 . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "Subdivision of abdominal segment of trunk which in humans is demarcated from the front of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the front of the abdomen, it constitutes the abdomen[Modified from FMA]." . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "lumbar region" . [] oboInOwl:source "ncithesaurus:Lumbar_Region" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "UMLS:C0024090" . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "abdominal back" . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "back of abdomen" . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "dorsum of abdomen" . [] oboInOwl:hasDbXref "MA:0000027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "lower back" . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "lumbar part of back" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "lumbar region of back" . [] oboInOwl:hasDbXref "FMA:61681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "posterior part of abdomen" . [] oboInOwl:hasDbXref "FMA:61681", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "regio lumbalis" . [] oboInOwl:hasDbXref "BTO:0001505", "Wikipedia:Loin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005462 ; owl:annotatedTarget "loin" . [] oboInOwl:hasDbXref "Wikipedia:Lymph_node#Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae." . [] oboInOwl:hasDbXref "Wikipedia:Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "marginal sinus" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "EMAPA:37662" . [] oboInOwl:source "ncithesaurus:Lymph_Node_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "UMLS:C1518051" . [] oboInOwl:source "ncithesaurus:Lymph_Node_Subcapsular_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "UMLS:C1518052" . [] oboInOwl:hasDbXref "MA:0003027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "lymph node subcortical sinus" . [] oboInOwl:hasDbXref "Wikipedia:Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "lymph path" . [] oboInOwl:hasDbXref "Wikipedia:Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "lymph sinus" . [] oboInOwl:hasDbXref "Wikipedia:Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "marginal sinus of lymph node" . [] oboInOwl:hasDbXref "Wikipedia:Subcapsular_sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005463 ; owl:annotatedTarget "subcapsular sinus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000963 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "Wikipedia:Obturator_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005465 ; owl:annotatedTarget "The obturator nerve arises from the ventral divisions of the second, third, and fourth lumbar nerves; the branch from the third is the largest, while that from the second is often very small." . [] oboInOwl:source "ncithesaurus:Obturator_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005465 ; owl:annotatedTarget "UMLS:C0028783" . [] oboInOwl:hasDbXref "Wikipedia:Obturator_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005465 ; owl:annotatedTarget "nervus obturatorius" . [] oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:notes "cervical branch of the facial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget _:genid141272 . [] oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget _:genid141274 . [] oboInOwl:notes "base of mandible; skin of cheek and lower lip; angle of mouth; orbicularis oris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget _:genid141276 . [] oboInOwl:notes "base of mandible; skin of cheek and lower lip; angle of mouth; orbicularis oris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget _:genid141278 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "Halide" . [] oboInOwl:hasDbXref "GOC:add", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:9280752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000963 ; owl:annotatedTarget "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." . [] oboInOwl:hasDbXref "MFMO:0000059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve. It attaches to the mandible and it attaches to the skin of the head, neck, and thoracic region where it is found superficial to the clavicle. Burrows et al. (2011) argue that in hylobatids (and, presumably, other primates) the platysma in the region of the modiolus represents both the cervicale and myoides muscles." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve, and attaches to the skin.[FEED]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000931" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.398", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "One of these (facial muscles in mammals), the platysma, is an unspecialized muscle derived from the hyoid arch.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Platysma_Myoides" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "UMLS:C1514163" . [] oboInOwl:hasDbXref "BTO:0005124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "platysma muscle" . [] oboInOwl:hasDbXref "PMID:19531159" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "platysma cervicale" . [] oboInOwl:hasDbXref "PMID:19531159" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "platysma myoides" . [] oboInOwl:hasDbXref "BTO:0005124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005467 ; owl:annotatedTarget "neck platysma muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005469 ; owl:annotatedTarget "A thymus lobe that is in the right side of a thymus." . [] oboInOwl:hasDbXref "FMA:71194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005469 ; owl:annotatedTarget "right lobe of thymus" . [] oboInOwl:hasDbXref "FMA:71194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005469 ; owl:annotatedTarget "right thymic lobe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005472 ; owl:annotatedTarget "A vitelline vein that is in the right side of a multicellular organism." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "A subdivision of an organism along the anterior-posterior axis in the pelvic region immediately posterior to the lumbar region and anterior to the caudal region. Sometimes an intermediate region is defined between the sacral and caudal." . [] oboInOwl:hasDbXref "FMA:24228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "back of pelvis" . [] oboInOwl:hasDbXref "FMA:24228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "pelvic back" . [] oboInOwl:hasDbXref "FMA:24228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "posterior part of pelvis" . [] oboInOwl:hasDbXref "FMA:24228", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "regio sacralis" . [] oboInOwl:hasDbXref "FMA:24228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "sacral part of pelvis" . [] oboInOwl:hasDbXref "Wikipedia:Rump_(animal)" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "croup" . _:genid139929 oboInOwl:hasDbXref "Wikipedia:Rump_(animal)" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "hindquarter" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001310 . [] oboInOwl:hasDbXref "Wikipedia:Rump_(animal)" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005473 ; owl:annotatedTarget "rump" . _:genid139931 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000033, obo:UBERON_0001312 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005475 ; owl:annotatedTarget obo:UBERON_0017635 . [] oboInOwl:source "Palaeos" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005475 ; owl:annotatedTarget _:genid141313 . [] oboInOwl:hasDbXref "Wikipedia:Sigmoid_sinus", "http://palaeos.com/vertebrates/glossary/glossaryS.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005475 ; owl:annotatedTarget "A portion of the lateral venous sinus, bulging prominently into the mastoid cavity, that serves as a principal conduit by which blood leaves the cranium[EPIC]. The sigmoid is drained by the internal jugular vein." . [] oboInOwl:source "Wikipedia:Sigmoid_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005475 ; owl:annotatedTarget "The sigmoid sinuses, within a human head, are 2 areas beneath the brain, which allow blood veins to span the area, from the center of the head downward. They drain from the transverse sinuses (under the back of the brain) to the internal jugular vein. Each sigmoid sinus begins beneath the temporal bone and follows a tortuous course to the jugular foramen, at which point the sinus becomes continuous with the internal jugular vein[Wikipedia:Sigmoid_sinus]." . [] oboInOwl:hasDbXref "Wikipedia:Sigmoid_sinus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005475 ; owl:annotatedTarget "sulcus sigmoideus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005476 ; owl:annotatedTarget "Trunk part of spinal nerve, where dorsal and ventral roots meet to form the spinal nerve, before branching off to dorsal and ventral rami." . [] oboInOwl:hasDbXref "FMA:5929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005476 ; owl:annotatedTarget "spinal nerve (trunk)" . _:genid139943 oboInOwl:hasDbXref "FMA:5929" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005476 ; owl:annotatedTarget "spinal neural trunk" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001619 . [] oboInOwl:hasDbXref "FMA:5929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005476 ; owl:annotatedTarget "trunk of spinal nerve" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005478 ; owl:annotatedTarget _:genid141326 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/Sulcus+limitans", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005478 ; owl:annotatedTarget "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]." . [] oboInOwl:hasDbXref "EHDAA2:0001265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005478 ; owl:annotatedTarget "neural tube lateral wall sulcus limitans" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005483 ; owl:annotatedTarget _:genid141334 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005483 ; owl:annotatedTarget "Either of the two lateral lobes that constitute the thymus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005483 ; owl:annotatedTarget "lateral lobe of thymus" . [] oboInOwl:hasDbXref "FMA:71193" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005483 ; owl:annotatedTarget "lobe of thymus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "A valve leaflet that is part of a tricuspid valve." . [] oboInOwl:source "FMA:7237" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "Leaf of caridac valve which has as its parts the anterior, posterior and septal leaflets that is is attached to the chorda tendinea of the right ventricle and the fibrous ring of tricuspid valve." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000821" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "FMA:7237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "leaflet of tricuspid valve" . _:genid139965 oboInOwl:hasDbXref "FMA:7237" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "tricuspid valve leaflet" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004042 . [] oboInOwl:hasDbXref "VHOG:0000821" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "tricuspid valve leaflets" . [] oboInOwl:hasDbXref "FMA:7237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005484 ; owl:annotatedTarget "tricuspid valvular leaflet" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget _:genid141355 . [] oboInOwl:hasDbXref "Wikipedia:Dural_venous_sinuses" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "A venous channel found between layers of dura mater in the brain. Receives blood from internal and external veins of the brain, receive cerebrospinal fluid (CSF) from the subarachnoid space, and ultimately empty into the internal jugular vein." . [] oboInOwl:hasDbXref "FMA:50762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "cranial dural venous sinus" . [] oboInOwl:hasDbXref "FMA:50762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "dural sinus" . [] oboInOwl:hasDbXref "MA:0002113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "dural vein" . [] oboInOwl:hasDbXref "FMA:50762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "dural venous sinus" . [] oboInOwl:hasDbXref "EHDAA:6491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "venous dural" . [] oboInOwl:hasDbXref "EHDAA2:0002169" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "venous dural sinus" . [] oboInOwl:hasDbXref "Wikipedia:Dural_venous_sinuses" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005486 ; owl:annotatedTarget "s. durae matris" . _:genid139982 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001040 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000310 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0010666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "The paired veins that carry blood from the yolk sac back to the embryo." . [] oboInOwl:ontology "XAO" ; oboInOwl:source "XAO:0004147" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "One of two veins that run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.[XAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000401" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG]" . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "check zfa (no text def). Check vitelline/omphalomesenteric distinction in XAO" . [] oboInOwl:source "ncithesaurus:Vitelline_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "UMLS:C0231091" . [] oboInOwl:hasDbXref "VHOG:0000401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "embryonic vitelline vein" . [] oboInOwl:hasDbXref "XAO:0004147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "vascular vitelline network" . [] oboInOwl:hasDbXref "Wikipedia:Vitelline_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "vena vitellina" . [] oboInOwl:hasDbXref "EMAPA:16244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "omphalomesenteric vein" . [] oboInOwl:hasDbXref "XAO:0004147" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005487 ; owl:annotatedTarget "vitelline veins" . [] oboInOwl:hasDbXref "ZFA:0007066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005491 ; owl:annotatedTarget "Cranial neural crest which gives rise to the glossopharyngeal ganglion." . [] oboInOwl:source "ZFA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget _:genid141382 . [] oboInOwl:hasDbXref "MP:0001289", "ZFA:0005046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "A blood vessel that is associated with the lens. In mammals, this is transient and normally nourishes the retina, immature lens and primary vitreous of the developing eye." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "a halide anion" . [] oboInOwl:hasDbXref "XAO:0004154" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "hyaloid blood vessels" . [] oboInOwl:hasDbXref "TAO:0005046" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "hyaloid vessels" . [] oboInOwl:hasDbXref "MP:0001289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "hyaloid capillary system" . [] oboInOwl:hasDbXref "MP:0001289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "hyaloid vascular system" . [] oboInOwl:hasDbXref "ZFA:0005046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005492 ; owl:annotatedTarget "hyaloid vasculature" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget _:genid141390 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget _:genid141392 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget _:genid141395 . [] oboInOwl:hasDbXref "http://www.answers.com/topic/hyoid-muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget "One of a group of muscles used in mastication and swallowing. These muscles are attached to the hyoid bone, which is suspended in the neck and forms the base of the tongue and larynx. The muscles are divided into suprahyoid (superior) or infrahyoid (inferior) groups relative to the bone[WP, generalized]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001494" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1186/1471-213X-8-24 Diogo R, Hinits Y, Hughes SM, Development of mandibular, hyoid and hypobranchial muscles in the zebrafish: homologies and evolution of these muscles within bony fishes and tetrapods. BMC Developmental Biology (2008)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget "Although the zebrafish occupies a rather derived phylogenetic position within actinopterygians and even within teleosts, with respect to the mandibular, hyoid and hypobranchial muscles it seems justified to consider it an appropriate representative of these two groups. Among these muscles, the three with clear homologues in tetrapods and the further three identified in sarcopterygian fish are particularly appropriate for comparisons of results between the actinopterygian zebrafish and the sarcopterygians.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Hyoid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget "UMLS:C0448345" . [] oboInOwl:hasDbXref "ZFA:0000521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005493 ; owl:annotatedTarget "hyoid muscles" . [] oboInOwl:hasDbXref "ZFA:0001435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005496 ; owl:annotatedTarget "Portion of tissue on the side of the lumen of the neural tube." . [] oboInOwl:hasDbXref "ZFA:0001435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005496 ; owl:annotatedTarget "lateral wall neural tube" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget _:genid141405 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001372" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "non neural ectoderm" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000964 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "epidermal ectoderm" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "epithelial ectoderm" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "surface ectoderm" . [] oboInOwl:hasDbXref "ZFA:0001178" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005497 ; owl:annotatedTarget "ventral ectoderm" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005498 ; owl:annotatedTarget _:genid141414 . [] oboInOwl:hasDbXref "ZFA:0000149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005498 ; owl:annotatedTarget "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." . [] oboInOwl:hasDbXref "EMAPA:16215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005498 ; owl:annotatedTarget "primitive heart tube" . [] oboInOwl:hasDbXref "EMAPA:16208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005498 ; owl:annotatedTarget "early primitive heart tube" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005499 ; owl:annotatedTarget _:genid141419 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:17992590", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000964 ; owl:annotatedTarget "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." . [] oboInOwl:hasDbXref "ZFA:0001031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005499 ; owl:annotatedTarget "Hindbrain segment or neuromere 1." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001031" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005499 ; owl:annotatedTarget "Hindbrain segment or neuromere. Kimmel et al, 1995.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001031" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005499 ; owl:annotatedTarget "r1" . (obo:UBERON_0005496 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001892 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005501 ; owl:annotatedTarget "A neural tube lateral wall that is part of a rhombomere." . [] oboInOwl:hasDbXref "EMAPA:35364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005501 ; owl:annotatedTarget "future hindbrain lateral wall" . [] oboInOwl:hasDbXref "TAO:0001311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005502 ; owl:annotatedTarget "roof plate rhombomere" . [] oboInOwl:hasDbXref "ZFA:0001311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005502 ; owl:annotatedTarget "roof plate rhombomere region" . [] oboInOwl:hasDbXref "VHOG:0001018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005502 ; owl:annotatedTarget "roof plate rhombomeres" . [] oboInOwl:hasDbXref "EMAPA:35367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005502 ; owl:annotatedTarget "future hindbrain roof plate" . [] oboInOwl:hasDbXref "ZFA:0001311" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005502 ; owl:annotatedTarget "roof plate hindbrain" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget obo:UBERON_0000483 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget _:genid141440 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget _:genid141442 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget _:genid141444 . [] oboInOwl:notes "mesenchymal" ; oboInOwl:source "ZFA", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget _:genid141446 . [] oboInOwl:hasDbXref "ZFA:0001077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." . [] oboInOwl:source "ISBN:0781714125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "we follow Kardong table 13.1 in having some developmental contribution of pouch 4 in mammals, but this isn't reflected in EHDAA2. Consider adding distinct term for mesenchyme (see EHDAA2), to indicate NC constribution." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001077" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production. Willett et al, 1999.[TAO]" . [] oboInOwl:source "ISBN:0781714125" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "variability of developmental origin: In fish, thymic primordia are generated by all the pouches except the first. However, in avians the thymus arises from pouches 3 and 4, whereas in humans it is only generated by the third pouch[PMID:16313389] The thymus arises from the second pouch in frogs, 2-6 in cartilaginous fish, 2-3 in reptiles, 3 or 4 in bony fish, birds and mammals. The final number is variable - 5 paired organs in sharks, 4 in caecilians, 3 in urodeles, 1 in many teleost, anurans and many mammals" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "thymic primordium" . [] oboInOwl:hasDbXref "ZFA:0001077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005562 ; owl:annotatedTarget "thymic rudiment" . _:genid140059 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005563 ; owl:annotatedTarget obo:UBERON_0003099 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001294 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005563 ; owl:annotatedTarget obo:UBERON_0007530 . _:genid140061 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005563 ; owl:annotatedTarget _:genid141456 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005211 . [] oboInOwl:hasDbXref "ZFA:0000080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005563 ; owl:annotatedTarget "Cranial neural crest which gives rise to the trigeminal ganglion." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000269" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005563 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget _:genid141461 . [] oboInOwl:hasDbXref "ZFA:0001262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "Portion of tissue that gives rise to the immature gonad." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001262" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "Immature reproductive tissue that has not undergone final maturation into either testis or ovary.[TAO]" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "future gonad" . [] oboInOwl:hasDbXref "ZFA:0001262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "gonadal primordium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "primitive gonad" . [] oboInOwl:hasDbXref "ZFA:0001262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "undifferentiated gonad" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005564 ; owl:annotatedTarget "immature gonad" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005565 ; owl:annotatedTarget obo:UBERON_0007530 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005565 ; owl:annotatedTarget _:genid141472 . [] oboInOwl:hasDbXref "ZFA:0000762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005565 ; owl:annotatedTarget "Cranial neural crest that gives rise to the facio-acoustic ganglion." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000268" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005565 ; owl:annotatedTarget "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005565 ; owl:annotatedTarget "facio acoustic neural crest" . _:genid140083 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005567 ; owl:annotatedTarget "A rhombomere lateral wall that is part of a rhombomere 1." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005234 . [] oboInOwl:hasDbXref "ZFA:0000781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005567 ; owl:annotatedTarget "lateral wall rhombomere 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005568 ; owl:annotatedTarget "A rhombomere roof plate that is part of a rhombomere 1." . [] oboInOwl:hasDbXref "ZFA:0001033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005568 ; owl:annotatedTarget "roof plate rhombomere 1" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget _:genid141493 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget _:genid141495 . [] oboInOwl:hasDbXref "PMID:11830559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget "Somite located in the head region, caudal to the otic vesicle." . [] oboInOwl:source "PMID:11830559" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget "They provide the epaxial and hypaxial muscles of the neck, the pharyngeal and laryngeal muscles that develop in the caudal branchial arches and the musculature of the tongue. Despite their localisation in the head, myogenic precursors from occipital somites essentially follow the trunk programmes (E. H. Walters and S. D., unpublished). during evolution, have been secondarily incorporated into the head (Gans and Northcutt, 1983)" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget "EHDAA2 has both 'head somite' and 'head somite group', with part_of and develops_from for latter" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "halide anions" . [] oboInOwl:hasDbXref "PMID:11830559", "XAO:0000313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget "occipital somite" . [] oboInOwl:hasDbXref "XAO:0000313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005594 ; owl:annotatedTarget "cranial somite" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget _:genid141504 . [] oboInOwl:hasDbXref "XAO:0001002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." . [] oboInOwl:hasDbXref "XAO:0001002" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget "lateral diverticula" . [] oboInOwl:hasDbXref "AAO:3010717" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget "lung diverticulum" . [] oboInOwl:hasDbXref "EFO:0002578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005597 ; owl:annotatedTarget "lung endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005598 ; owl:annotatedTarget "A somite that is part of a trunk." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget obo:UBERON_0003281 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget _:genid141517 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget _:genid141519 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_mesentery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000352" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mesogastrium" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget "The dorsal sheet of the primitive mesentery that encloses the stomach. The greater omentum develops from the dorsal mesogastrium. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Dorsal_Mesogastrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget "UMLS:C1512038" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005602 ; owl:annotatedTarget "dorsal mesentery" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005604 ; owl:annotatedTarget _:genid141525 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005604 ; owl:annotatedTarget _:genid141527 . [] oboInOwl:hasDbXref "VHOG:0000215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005604 ; owl:annotatedTarget "extrahepatic part of the hepatic duct" . _:genid140125 oboInOwl:hasDbXref "MA:0001636" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005604 ; owl:annotatedTarget "hepatic duct extrahepatic part" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003371 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001477" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/hyaloid+fossa" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005606 ; owl:annotatedTarget "A depression in the front of the vitreous body, lodging the lens. [adapted_from_the_definition_of_the_hyaloid_fossa]" . [] oboInOwl:hasDbXref "Wikipedia:Iliac_artery", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005609 ; owl:annotatedTarget "Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery." . _:genid140133 oboInOwl:external_ontology "XAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005609 ; owl:annotatedTarget "we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003248 . [] oboInOwl:source "ncithesaurus:Iliac_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005609 ; owl:annotatedTarget "UMLS:C0020887" . [] oboInOwl:hasDbXref "ncithesaurus:Iliac_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005610 ; owl:annotatedTarget "Any of the three veins including the common, external and internal iliac veins." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005610 ; owl:annotatedTarget "EMAPA:37151" . [] oboInOwl:source "ncithesaurus:Iliac_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005610 ; owl:annotatedTarget "UMLS:C0020888" . ( ) . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget obo:UBERON_0006726 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "A corner of the medial (inner) part of an eye." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000829" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "The angle at the end of the palpebral fissure, the slit between the eyelids, close to the nose. [ISBN:0124020607, p.263][VHOG]" . [] oboInOwl:source "ncithesaurus:Inner_Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "UMLS:C1708516" . [] oboInOwl:hasDbXref "FMA:59316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "medial palpebral commissure" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "inner canthi" . [] oboInOwl:hasDbXref "MA:0001262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005611 ; owl:annotatedTarget "medial canthus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget obo:CL_0000844 . _:genid140151 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000484" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0174480198 Roberts MBV, Biology: a functional approach (1986) p.572", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005613 ; owl:annotatedTarget "A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:source "http://emedicine.medscape.com/article/899609-overview" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0005613 ; owl:annotatedTarget "Contributes to the arch of aorta in humans" . ( ) . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." . [] oboInOwl:source "FMA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget _:genid141564 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex." . [] oboInOwl:source "ncithesaurus:Subcapsular_Epithelium_of_the_Lens" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "UMLS:C1182652" . [] oboInOwl:hasDbXref "http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "lens subcapsular epithelium" . [] oboInOwl:hasDbXref "FMA:70612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "subcapsular lens epithelium" . [] oboInOwl:hasDbXref "EMAPA:17304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "anterior epithelium of lens vesicle" . _:genid140166 oboInOwl:hasDbXref "FMA:58889" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005614 ; owl:annotatedTarget "anterior surface of lens" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000965 ; owl:annotatedTarget "centroblast" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005616 ; owl:annotatedTarget _:genid141577 . [] oboInOwl:hasDbXref "MESH:A07.231.114.565", "Wikipedia:Mesenteric_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005616 ; owl:annotatedTarget "Arteries which arise from the abdominal aorta and distribute to most of the intestines." . [] oboInOwl:source "ncithesaurus:Mesenteric_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005616 ; owl:annotatedTarget "UMLS:C0025465" . [] oboInOwl:hasDbXref "MESH:A07.231.908.670.385", "Wikipedia:Mesenteric_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005617 ; owl:annotatedTarget "A vein that returns blood from the intestines." . [] oboInOwl:source "ncithesaurus:Mesenteric_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005617 ; owl:annotatedTarget "UMLS:C0025473" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005617 ; owl:annotatedTarget "intestinal vein" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget _:genid141588 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget _:genid141590 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/palatal+shelves", "http://www.indiana.edu/~anat550/hnanim/face/face.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "The outgrowths of the embryonic maxillary prominences that come together during prenatal development to form the secondary palate." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000378" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/palatal" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "The outgrowths of the embryonic maxillae that come together during prenatal development to form the secondary palate. [TFD][VHOG]" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/palatal+shelf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "lateral palatine process" . [] oboInOwl:hasDbXref "MA:0001581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "palatal shelf" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "palatal shelves" . [] oboInOwl:hasDbXref "VHOG:0000378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005619 ; owl:annotatedTarget "palatine shelf" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000485" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0174480198 Roberts MBV, Biology: a functional approach (1986) p.572", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005622 ; owl:annotatedTarget "A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG]" . [] oboInOwl:source "http://emedicine.medscape.com/article/899609-overview" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0005622 ; owl:annotatedTarget "Normally regresses in humans" . [] oboInOwl:hasDbXref "MGI:pvb", "MP:0002746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005623 ; owl:annotatedTarget "The valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001393" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005623 ; owl:annotatedTarget "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" . [] oboInOwl:hasDbXref "MA:0002790" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005623 ; owl:annotatedTarget "semilunar valve" . [] oboInOwl:hasDbXref "MA:0002790" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005623 ; owl:annotatedTarget "semilunar valves" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "halide(1-)" . [] oboInOwl:hasDbXref "Wikipedia:Adrenal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005624 ; owl:annotatedTarget "Artery that supplies blood to the adrenal glands." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005624 ; owl:annotatedTarget "EMAPA:37124" . [] oboInOwl:hasDbXref "MA:0001914", "Wikipedia:Adrenal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005624 ; owl:annotatedTarget "adrenal artery" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005625 ; owl:annotatedTarget _:genid141616 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005625 ; owl:annotatedTarget _:genid141618 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005625 ; owl:annotatedTarget "The cavity formed by the tubotympanic recess epithelium." . [] oboInOwl:hasDbXref "EHDAA2:0002095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005625 ; owl:annotatedTarget "tubotympanic recess" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget _:genid141622 . [] oboInOwl:hasDbXref "Wikipedia:Ventral_mesentery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget "Portion of ventral mesentery closest to the stomach." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005133" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget "The mesentery that originates from the ventral side of the peritoneal cavity.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000351" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/mesogastrium" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget "The ventral sheet of the primitive mesentery that encloses the stomach. The lesser omentum develops from the ventral mesogastrium. [TFD][VHOG]" . [] oboInOwl:source "ncithesaurus:Ventral_Mesogastrium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget "UMLS:C1519967" . [] oboInOwl:hasDbXref "Wikipedia:Ventral_mesentery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005626 ; owl:annotatedTarget "foregut ventral mesentery" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=70052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005629 ; owl:annotatedTarget "A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part." . [] oboInOwl:source "Wikipedia:Plexus#Circulatory_system" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005629 ; owl:annotatedTarget "In a vascular plexus, the contents of the vessels mix. A plexus allows blood to flow via multiple routes. If one branch of the plexus is obstructed, the blood may flow via the open branches[Wikipedia:Plexus#Circulatory_system]." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005629 ; owl:annotatedTarget "plexus vasculosus" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005631 ; owl:annotatedTarget "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005631 ; owl:annotatedTarget "EHDAA2 is a mereological sum." . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005637 ; owl:annotatedTarget "An epithelium that is part of a pylorus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005638 ; owl:annotatedTarget "An epithelium that is part of a anterior chamber of eyeball." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005645 ; owl:annotatedTarget "An epithelium that is part of a manual digit 2." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005645 ; owl:annotatedTarget "fore limb digit 2 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005645 ; owl:annotatedTarget "manual digit II epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005645 ; owl:annotatedTarget "hand digit 2 epithelium" . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005646 ; owl:annotatedTarget "An epithelium that is part of a manual digit 3." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005646 ; owl:annotatedTarget "fore limb digit 3 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005646 ; owl:annotatedTarget "manual digit III epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005646 ; owl:annotatedTarget "hand digit 3 epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005647 ; owl:annotatedTarget "An epithelium that is part of a manual digit 4." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005647 ; owl:annotatedTarget "fore limb digit 4 epithelium" . _:genid140258 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005647 ; owl:annotatedTarget "manual digit IV epithelium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009142 . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005647 ; owl:annotatedTarget "hand digit 4 epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005648 ; owl:annotatedTarget "An epithelium that is part of a manual digit 5." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005648 ; owl:annotatedTarget "fore limb digit 5 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005648 ; owl:annotatedTarget "manual digit V epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005648 ; owl:annotatedTarget "hand digit 5 epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005649 ; owl:annotatedTarget "An epithelium that is part of a pedal digit 2." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005649 ; owl:annotatedTarget "hind limb digit 2 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005649 ; owl:annotatedTarget "pedal digit II epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005649 ; owl:annotatedTarget "foot digit 2 epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005650 ; owl:annotatedTarget "An epithelium that is part of a pedal digit 3." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005650 ; owl:annotatedTarget "hind limb digit 3 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005650 ; owl:annotatedTarget "pedal digit III epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005650 ; owl:annotatedTarget "foot digit 3 epithelium" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005651 ; owl:annotatedTarget "An epithelium that is part of a pedal digit 4." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005651 ; owl:annotatedTarget "hind limb digit 4 epithelium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget obo:CL_0000844 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005651 ; owl:annotatedTarget "pedal digit IV epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005651 ; owl:annotatedTarget "foot digit 4 epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005652 ; owl:annotatedTarget "An epithelium that is part of a pedal digit 5." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005652 ; owl:annotatedTarget "hind limb digit 5 epithelium" . _:genid140298 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005652 ; owl:annotatedTarget "pedal digit V epithelium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005652 ; owl:annotatedTarget "foot digit 5 epithelium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "halides" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:18432934", "PMID:8006591" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005653 ; owl:annotatedTarget "A dental epithelium that is part of a upper jaw molar." . _:genid140308 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225, obo:UBERON_0003667 . [] oboInOwl:hasDbXref "PMID:17992590" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0000966 ; owl:annotatedTarget "centrocyte" . _:genid140310 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005215, obo:UBERON_0011642 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005654 ; owl:annotatedTarget "A dental epithelium that is part of a lower jaw molar." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005656 ; owl:annotatedTarget "An epithelium that is part of a lens vesicle." . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005619 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005658 ; owl:annotatedTarget "An epithelium that is part of a secondary palatal shelf." . [] oboInOwl:hasDbXref "VHOG:0001040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005658 ; owl:annotatedTarget "palatal shelf epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005660 ; owl:annotatedTarget "An ectoderm that is part of a pharyngeal arch 2." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001062" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005660 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005660 ; owl:annotatedTarget "2nd pharyngeal arch ectoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005661 ; owl:annotatedTarget "An ectoderm that is part of a pharyngeal arch 3." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000946" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005661 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005661 ; owl:annotatedTarget "3rd pharyngeal arch ectoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005662 ; owl:annotatedTarget "An ectoderm that is part of a pharyngeal arch 4." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001095" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005662 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005662 ; owl:annotatedTarget "4th pharyngeal arch ectoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005664 ; owl:annotatedTarget "An endoderm that is part of a pharyngeal arch 2." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001108" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005664 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005664 ; owl:annotatedTarget "2nd pharyngeal arch endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005665 ; owl:annotatedTarget "An endoderm that is part of a pharyngeal arch 3." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001081" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005665 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005665 ; owl:annotatedTarget "3rd pharyngeal arch endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005666 ; owl:annotatedTarget "An endoderm that is part of a pharyngeal arch 4." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001092" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005666 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005666 ; owl:annotatedTarget "4th pharyngeal arch endoderm" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005667 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005667 ; owl:annotatedTarget _:genid141778 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005667 ; owl:annotatedTarget _:genid141780 . _:genid140368 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001136 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005358 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "A mesothelium that is part of a peritoneal cavity." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "we believe that this corresponds to EMAPA:16139 based on synonyms and parenthood" . [] oboInOwl:hasDbXref "EMAPA:16139" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "peritoneum" . [] oboInOwl:hasDbXref "EMAPA:16139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "mesothelium of peritoneal component" . [] oboInOwl:hasDbXref "FMA:18147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "mesothelium of peritoneum" . [] oboInOwl:hasDbXref "BTO:0003156", "EMAPA:16139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "peritoneal mesothelium" . [] oboInOwl:hasDbXref "FMA:18147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005669 ; owl:annotatedTarget "peritoneum mesothelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005672 ; owl:annotatedTarget "An endothelium that is part of a right lung." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005673 ; owl:annotatedTarget "An endothelium that is part of a left lung." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005685 ; owl:annotatedTarget "A dorsal mesentery that is part of a midgut." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005687 ; owl:annotatedTarget obo:UBERON_0005863 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005687 ; owl:annotatedTarget _:genid141813 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16042 ; owl:annotatedTarget "halogen anion" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005687 ; owl:annotatedTarget _:genid141815 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005687 ; owl:annotatedTarget "An orbitosphenoid endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0001329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005687 ; owl:annotatedTarget "sphenoid lesser wing cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005688 ; owl:annotatedTarget "An anatomical cavity that is part of a lens vesicle." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000531" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005688 ; owl:annotatedTarget "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005688 ; owl:annotatedTarget "lens cavity" . [] oboInOwl:hasDbXref "EMAPA:17164" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005688 ; owl:annotatedTarget "cavity of lens vesicle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005689 ; owl:annotatedTarget "Mesenchyme that is part of a pharyngeal arch 2." . _:genid140417 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001102" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005689 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010096 . [] oboInOwl:hasDbXref "VHOG:0001102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005689 ; owl:annotatedTarget "2nd pharyngeal arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005690 ; owl:annotatedTarget "Mesenchyme that is part of a pharyngeal arch 3." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001083" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005690 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005690 ; owl:annotatedTarget "3rd pharyngeal arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005691 ; owl:annotatedTarget "Mesenchyme that is part of a pharyngeal arch 4." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001052" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005691 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001052" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005691 ; owl:annotatedTarget "4th pharyngeal arch mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005692 ; owl:annotatedTarget "Mesenchyme that is part of a developing manual digit 2." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005692 ; owl:annotatedTarget "fore limb digit 2 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005692 ; owl:annotatedTarget "manual digit II mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005692 ; owl:annotatedTarget "hand digit 2 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005693 ; owl:annotatedTarget "Mesenchyme that is part of a developing manual digit 3." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005693 ; owl:annotatedTarget "fore limb digit 3 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005693 ; owl:annotatedTarget "manual digit III mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005693 ; owl:annotatedTarget "hand digit 3 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005694 ; owl:annotatedTarget "Mesenchyme that is part of a developing manual digit 4." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005694 ; owl:annotatedTarget "fore limb digit 4 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005694 ; owl:annotatedTarget "manual digit IV mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005694 ; owl:annotatedTarget "hand digit 4 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005695 ; owl:annotatedTarget "Mesenchyme that is part of a developing manual digit 5." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005695 ; owl:annotatedTarget "fore limb digit 5 mesenchyme" . _:genid140463 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005695 ; owl:annotatedTarget "manual digit V mesenchyme" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0010141 . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005695 ; owl:annotatedTarget "hand digit 5 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005696 ; owl:annotatedTarget "Mesenchyme that is part of a developing pedal digit 2." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005696 ; owl:annotatedTarget "hind limb digit 2 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005696 ; owl:annotatedTarget "pedal digit II mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005696 ; owl:annotatedTarget "foot digit 2 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005697 ; owl:annotatedTarget "Mesenchyme that is part of a developing pedal digit 3." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005697 ; owl:annotatedTarget "hind limb digit 3 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005697 ; owl:annotatedTarget "pedal digit III mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005697 ; owl:annotatedTarget "foot digit 3 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005698 ; owl:annotatedTarget "Mesenchyme that is part of a developing pedal digit 4." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005698 ; owl:annotatedTarget "hind limb digit 4 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005698 ; owl:annotatedTarget "pedal digit IV mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005698 ; owl:annotatedTarget "foot digit 4 mesenchyme" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget obo:CL_0000787 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005699 ; owl:annotatedTarget "Mesenchyme that is part of a developing pedal digit 5." . _:genid140494 oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005699 ; owl:annotatedTarget "hind limb digit 5 mesenchyme" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005309 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005699 ; owl:annotatedTarget "pedal digit V mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005699 ; owl:annotatedTarget "foot digit 5 mesenchyme" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." . _:genid140501 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005700 ; owl:annotatedTarget _:genid141917 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005700 ; owl:annotatedTarget "An odontogenic papilla that is part of a upper jaw molar." . _:genid140503 oboInOwl:hasDbXref "EHDAA2:0002127" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005700 ; owl:annotatedTarget "upper jaw molar dental papilla" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008425 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005701 ; owl:annotatedTarget _:genid141925 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005701 ; owl:annotatedTarget "An odontogenic papilla that is part of a lower jaw molar." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "IgD+ memory B cell" . [] oboInOwl:hasDbXref "EHDAA2:0001027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005701 ; owl:annotatedTarget "lower jaw molar dental papilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005702 ; owl:annotatedTarget "Mesenchyme that is part of a optic eminence." . [] oboInOwl:hasDbXref "HP:0032126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0000970 ; owl:annotatedTarget "non-class-switched memory B cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005704 ; owl:annotatedTarget "Mesenchyme that is part of a developing secondary palatal shelf." . [] oboInOwl:hasDbXref "VHOG:0001063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005704 ; owl:annotatedTarget "palatal shelf mesenchyme" . (obo:UBERON_0001763 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003450 ] ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005707 ; owl:annotatedTarget _:genid141944 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005707 ; owl:annotatedTarget "An odontogenic papilla that is part of a upper jaw incisor." . [] oboInOwl:hasDbXref "EHDAA2:0002123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005707 ; owl:annotatedTarget "upper jaw incisor dental papilla" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005708 ; owl:annotatedTarget _:genid141952 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005708 ; owl:annotatedTarget "An odontogenic papilla that is part of a lower jaw incisor." . _:genid140535 oboInOwl:hasDbXref "EHDAA2:0001023" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005708 ; owl:annotatedTarget "lower jaw incisor dental papilla" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005323 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005709 ; owl:annotatedTarget "A dental epithelium that is part of a upper jaw incisor." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005710 ; owl:annotatedTarget "A dental epithelium that is part of a lower jaw incisor." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005711 ; owl:annotatedTarget "A mesentery of duodenum that is part of a foregut." . _:genid140558 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005325, obo:UBERON_0011642 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005712 ; owl:annotatedTarget "A mesentery of duodenum that is part of a midgut." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005719 ; owl:annotatedTarget _:genid141984 . _:genid140565 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005719 ; owl:annotatedTarget "An apical ectodermal ridge that is part of a footplate." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005322 . (obo:UBERON_0004582 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005720 ; owl:annotatedTarget "A venous system that is part of a hindbrain." . [] oboInOwl:hasDbXref "VHOG:0001322" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005720 ; owl:annotatedTarget "rhombencephalon venous system" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget _:genid141997 . [] oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget _:genid141999 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "A mesoderm that has the potential to develop into a pronephros." . _:genid140579 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011090" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "Portion of tissue that consists of the mesenchymal precursor to the pronephric kidney and that begins to separate from the intermediate mesoderm at NF stage 21 and epithelializes by NF stage 30.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005322 . [] oboInOwl:hasDbXref "XAO:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "pronephric anlage" . [] oboInOwl:hasDbXref "XAO:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "pronephric bulge" . [] oboInOwl:hasDbXref "XAO:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "pronephric mesenchyme" . [] oboInOwl:hasDbXref "XAO:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005721 ; owl:annotatedTarget "pronephric primordium" . _:genid140586 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002240, obo:UBERON_0010534 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000971 ; owl:annotatedTarget "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005724 ; owl:annotatedTarget "A tissue that is part of a spinal cord and is part of a roof plate." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000777" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005724 ; owl:annotatedTarget "Roof plate that is part of the spinal cord. [Bgee_curator][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000777" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005724 ; owl:annotatedTarget "roof plate spinal cord" . [] oboInOwl:hasDbXref "VHOG:0000777" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005724 ; owl:annotatedTarget "roofplate spinal cord" . [] oboInOwl:hasDbXref "VHOG:0000777" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005724 ; owl:annotatedTarget "spinal cord roof" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005725 ; owl:annotatedTarget "A sensory system that is capable of olfaction (the sensory perception of smell)." . [] oboInOwl:source "Wikipedia:Olfactory_system" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005725 ; owl:annotatedTarget "The olfactory system is the sensory system used for olfaction, or the sense of smell. Most mammals and reptiles have two distinct parts to their olfactory system: a main olfactory system and an accessory olfactory system. The main olfactory system detects volatile, airborne substances, while the accessory olfactory system senses fluid-phase stimuli. Behavioral evidence indicates that most often, the stimuli detected by the accessory olfactory system are pheromones. The olfactory system is often spoken of along with the gustatory system as the chemosensory senses because both transduce chemical signals into perception[WP][Wikipedia:Olfactory_system]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000978" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005725 ; owl:annotatedTarget "The sensory system used for olfaction (the sense of smell).[AAO]" . [] oboInOwl:source "ncithesaurus:Olfactory_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005725 ; owl:annotatedTarget "UMLS:C0228065" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005728 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005728 ; owl:annotatedTarget _:genid142035 . [] oboInOwl:hasDbXref "http://www.ana.ed.ac.uk/database/humat/notes/extraemb/mesoder.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005728 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005729 ; owl:annotatedTarget "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001453" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005729 ; owl:annotatedTarget "Embryonic region that develops into the pectoral fin bud.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001453" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005729 ; owl:annotatedTarget "pectoral fin field" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005730 ; owl:annotatedTarget "A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001454" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005730 ; owl:annotatedTarget "Embryonic region that develops into the pelvic fin bud.[TAO]" . _:genid140627 oboInOwl:hasDbXref "ZFA:0001454" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005730 ; owl:annotatedTarget "pelvic fin field" ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001950 . [] oboInOwl:source "ISBN:9780878932504", "ZFA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005732 ; owl:annotatedTarget _:genid142056 . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005732 ; owl:annotatedTarget "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." . [] oboInOwl:hasDbXref "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005733 ; owl:annotatedTarget "A ring of cells capable of forming a limb." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget obo:UBERON_0004797 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "The outermost layer of a blood vessel, composed mainly of fibrous tissue." . [] oboInOwl:source "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]." . [] oboInOwl:source "ncithesaurus:Tunica_Adventitia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "UMLS:C0225342" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "adventitia externa" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "tunica adventitia" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "tunica adventitia of vessel" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "external coat" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "tunica adventitia vasorum" . [] oboInOwl:hasDbXref "Wikipedia:Tunica_externa_(vessels)" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005734 ; owl:annotatedTarget "tunica externa vasorum" . _:genid140656 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005740 ; owl:annotatedTarget "A tunica intima that is part of a artery." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009126 . [] oboInOwl:hasDbXref "EV:0100028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005740 ; owl:annotatedTarget "arterial intima" . _:genid140658 oboInOwl:hasDbXref "FMA:14272" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005740 ; owl:annotatedTarget "tunica interna (intima)(arteriae)" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010258 . [] oboInOwl:hasDbXref "Wikipedia:Adventitia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005742 ; owl:annotatedTarget "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Adventitia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005742 ; owl:annotatedTarget "tunica advetitia" . [] oboInOwl:hasDbXref "FMA:45635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005742 ; owl:annotatedTarget "tunica externa" . [] oboInOwl:hasDbXref "TAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005744 ; owl:annotatedTarget "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005744 ; owl:annotatedTarget "in FMA and ZFA this is a conduit space, not a conduit. Note there may be some additional disambiguation required: foramen is used loosely in the sense of any opening (e.g. foramen primum). FMA appears to use cranial conduit (undefined) in the sense of any foramen of the skull (includes mental foramen, which is not in the cranium proper)." . [] oboInOwl:hasDbXref "ZFA:0005386" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005744 ; owl:annotatedTarget "foramen" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget _:genid142101 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010704", "Wikipedia:Optic_canal", "https://github.com/obophenotype/uberon/issues/1213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "An opening in the skull through which cranial nerve II passes.[MP]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001408" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/optic+foramen" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "An aperture in the root of the lesser wing of the sphenoid bone transmitting the optic nerve. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002025" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "Foramen in the orbital region of the neurocranium for the passage of the optic nerve (cranial nerve II).[TAO]" . [] oboInOwl:external_class "MP:0010704" ; oboInOwl:ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "The short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery" . [] oboInOwl:hasDbXref "Wikipedia:Optic_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "optic canal" . [] oboInOwl:hasDbXref "Wikipedia:Optic_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "optic foramen" . [] oboInOwl:hasDbXref "ZFA:0005428", "ZFIN:ZDB-PUB-961014-192" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "optic nerve (II) foramen" . [] oboInOwl:hasDbXref "TAO:0002025" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "optic nerve foramen" . _:genid140686 oboInOwl:hasDbXref "Wikipedia:Optic_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "canalis opticus" ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0019230 . [] oboInOwl:hasDbXref "Wikipedia:Optic_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005745 ; owl:annotatedTarget "foramen opticum ossis sphenoidalis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000972 ; owl:annotatedTarget obo:CL_0000787 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005749 ; owl:annotatedTarget _:genid142115 . [] oboInOwl:hasDbXref "MP:0005325", "Wikipedia:Glomerulus", "http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005749 ; owl:annotatedTarget "The capillary loops of the kidney that normally function as a filtration unit[MP]." . [] oboInOwl:source "GudMap" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0005749 ; owl:annotatedTarget "...Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus" . [] oboInOwl:hasDbXref "EMAPA:28239" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005749 ; owl:annotatedTarget "glomerulus" . [] oboInOwl:hasDbXref "http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005753 ; owl:annotatedTarget "The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005753 ; owl:annotatedTarget "caudal portion of nephrogenic cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005753 ; owl:annotatedTarget "caudal region of nephrogenic cord" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005753 ; owl:annotatedTarget "rear part of nephrogenic cord" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "CAS:154-58-5" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:9295047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000972 ; owl:annotatedTarget "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." . [] oboInOwl:hasDbXref "Wikipedia:Metanephros#Metanephros" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005753 ; owl:annotatedTarget "rear portion of nephrogenic cord" . _:genid140701 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922, obo:UBERON_0002435 . [] oboInOwl:hasDbXref "http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005754 ; owl:annotatedTarget "The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005764 ; owl:annotatedTarget "An acellular anatomical structure that is the bounding layer of a anatomical structure." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget obo:UBERON_0005764 . [] oboInOwl:hasDbXref "Wikipedia:Basement_membrane", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." . [] oboInOwl:source "http://palaeos.com/metazoa/porifera/homoscleromorpha.html" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget obo:NCBITaxon_80999 . [] oboInOwl:source "ncithesaurus:Basement_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget "UMLS:C0004799" . [] oboInOwl:hasDbXref "FMA:63872" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget "basement membrane of connective tissue" . _:genid140718 oboInOwl:hasDbXref "Wikipedia:Basement_membrane" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget "membrana basalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005382 . [] oboInOwl:hasDbXref "FMA:63872" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005769 ; owl:annotatedTarget "basement membrane" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget _:genid142152 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005285" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-000824-1" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "Membrane between the mesonephric podocytes and the renal glomerular capillaries. It is a trilaminar structure composed of the fused basement membranes of the glomerular capillaries and basement membrane of the podocytes. The capillary membranes touch the GBM at contact points that are separated by pores. The membrane is semi-permeable allowing water and small molecules to pass into the renal capsular space.[TAO]" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "GBM" . [] oboInOwl:source "ncithesaurus:Glomerular_Basement_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "UMLS:C0599297" . [] oboInOwl:hasDbXref "MA:0001659" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "glomerular capillary basement membrane" . [] oboInOwl:hasDbXref "ZFA:0005285" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005777 ; owl:annotatedTarget "glomerular filtration membrane" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005788 ; owl:annotatedTarget "Layer of the glomerular basement membrane adjacent to the glomerular capillary." . [] oboInOwl:source "ncithesaurus:Lamina_Rara_Interna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005788 ; owl:annotatedTarget "UMLS:C1517719" . [] oboInOwl:hasDbXref "FMA:74277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005788 ; owl:annotatedTarget "internal layer of glomerular basement membrane" . [] oboInOwl:hasDbXref "FMA:74277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005788 ; owl:annotatedTarget "lamina interna of glomerular basement membrane" . [] oboInOwl:hasDbXref "http://cwx.prenhall.com/bookbind/pubbooks/martini10/chapter27/custom2/deluxe-content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005792 ; owl:annotatedTarget "Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions." . [] oboInOwl:hasDbXref "VHOG:0001240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005792 ; owl:annotatedTarget "nephric cord" . [] oboInOwl:hasDbXref "FMA:72173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005795 ; owl:annotatedTarget "fetal uterus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000973 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "ncithesaurus:Aortic_Segment" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005800 ; owl:annotatedTarget "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." . [] oboInOwl:source "ncithesaurus:Aortic_Segment" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005800 ; owl:annotatedTarget "UMLS:C0506947" . [] oboInOwl:hasDbXref "FMA:13087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005800 ; owl:annotatedTarget "aortic segment" . [] oboInOwl:hasDbXref "FMA:13087" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005800 ; owl:annotatedTarget "segment of aorta" . [] oboInOwl:hasDbXref "GO:0035907", "https://sourceforge.net/p/geneontology/ontology-requests/8525/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." . [] oboInOwl:source "Wikipedia:Dorsal_aorta" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "Each primitive aorta receives anteriorly a vein 'the vitelline vein' from the yolk-sac, and is prolonged backward on the lateral aspect of the notochord under the name of the dorsal aorta. The dorsal aortae give branches to the yolk-sac, and are continued backward through the body-stalk as the umbilical arteries to the villi of the chorion. The two dorsal aortae combine to become the descending aorta in later development[WP]." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000973 ; owl:annotatedTarget "A class switched memory B cell that expresses IgA." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000014" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "Principal unpaired, median artery of the trunk, leading from the paired roots (radices) of the dorsal aorta to the caudal artery. Kimmel et al, 1995.[TAO]" . [] oboInOwl:source "BTO:0004673" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "The artery in vertebrate embryos that transports blood from the aortic arches to the trunk and limbs. In adult fish it is a major artery that carries oxygenated blood from the efferent branchial arteries to branches that supply the body organ. In adult tetrapods it arises from the systemic arch" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000014" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "relationship loss: part_of axial vasculature (TAO:0001073)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000264" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "DA" . [] oboInOwl:hasDbXref "XAO:0000051" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "aorta dorsalis" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_aorta" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "aortae dorsales" . [] oboInOwl:hasDbXref "VHOG:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "dorsal aorta root" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_aorta" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "dorsal aortae" . [] oboInOwl:hasDbXref "VHOG:0000264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "dorsal aortic root" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_aorta" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005805 ; owl:annotatedTarget "dorsal aortæ" . [] oboInOwl:hasDbXref "Wikipedia:Portal_venous_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005806 ; owl:annotatedTarget "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." . [] oboInOwl:source "ncithesaurus:Portal_Venous_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005806 ; owl:annotatedTarget "UMLS:C0226727" . [] oboInOwl:hasDbXref "FMA:45628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005806 ; owl:annotatedTarget "portal venous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005808 ; owl:annotatedTarget "A bone tissue that is part of a long bone." . [] oboInOwl:hasDbXref "FMA:83117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005808 ; owl:annotatedTarget "osseous tissue of long bone" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005809 ; owl:annotatedTarget "The outer or sperficial part of a bone of the manus." . [] oboInOwl:hasDbXref "Wikipedia:Tubercle_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005813 ; owl:annotatedTarget "A round nodule, small eminence, or warty outgrowth on an anatomical surface, such as bones, skin, or within the lungs (in the case of tuberculosis). They are also found on the leading edge of Humpback Whale's flippers, improving fluid flow over the flipper's surface[WP]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005814 ; owl:annotatedTarget "A vertebral arch that is part of the first cervical vertebra." . [] oboInOwl:hasDbXref "FMA:23975" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005814 ; owl:annotatedTarget "atlas arch" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005837 ; owl:annotatedTarget "A fascicle that is part of a spinal cord." . [] oboInOwl:hasDbXref "FMA:75799" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005837 ; owl:annotatedTarget "spinal cord fasciculus" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "CAS:154-58-5" . _:genid140804 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001834, obo:UBERON_0002316 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005838 ; owl:annotatedTarget "A fascicle that is part of a brain." . [] oboInOwl:hasDbXref "FMA:83844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005838 ; owl:annotatedTarget "brain fasciculus" . _:genid140807 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005844 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0005473 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004068 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000979 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "A spinal cord segment that adjacent_to a sacral region." . [] oboInOwl:source "BIRNLEX:1275", "ncithesaurus:Sacral_Spinal_Cord" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "UMLS:C0581669" . [] oboInOwl:source "BIRNLEX:1275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "UMLS:C1280196" . [] oboInOwl:hasDbXref "FMA:256623", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "pars sacralis medullae spinalis" . _:genid140815 oboInOwl:hasDbXref "FMA:256623" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "sacral segment of spinal cord" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002435 . [] oboInOwl:hasDbXref "FMA:256623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "sacral segments of spinal cord [1-5]" . [] oboInOwl:hasDbXref "FMA:256623", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005843 ; owl:annotatedTarget "segmenta sacralia medullae spinalis [1-5]" . [] oboInOwl:hasDbXref "BIRNLEX:2665" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005844 ; owl:annotatedTarget "axial part of spinal cord" . [] oboInOwl:hasDbXref "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000979 ; owl:annotatedTarget "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." . [] oboInOwl:hasDbXref "BIRNLEX:2665" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005844 ; owl:annotatedTarget "axial regional part of spinal cord" . [] oboInOwl:hasDbXref "FMA:62420" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005844 ; owl:annotatedTarget "segment of spinal cord" . [] oboInOwl:hasDbXref "TAO:0001332" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005844 ; owl:annotatedTarget "spinal neuromeres" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "A spinal cord segment that adjacent_to a caudal region." . [] oboInOwl:hasDbXref "FMA:256635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "coccygeal segment of spinal cord" . [] oboInOwl:hasDbXref "FMA:256635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "coccygeal segments of spinal cord [1-3]" . [] oboInOwl:hasDbXref "FMA:256635", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "pars coccygea medullae spinalis" . [] oboInOwl:hasDbXref "FMA:256635", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "segmenta coccygea medullae spinalis [1-3]" . [] oboInOwl:hasDbXref "NeuroNames:1656" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005845 ; owl:annotatedTarget "segmenta coccygea" . (obo:UBERON_0016551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003038 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005852 ; owl:annotatedTarget "A subdivision of spinal cord ventral column that is part of a thoracic spinal cord." . [] oboInOwl:source "BIRNLEX:1448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005852 ; owl:annotatedTarget "UMLS:C0228636" . [] oboInOwl:source "BIRNLEX:1448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005852 ; owl:annotatedTarget "UMLS:C1288556" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005853 ; owl:annotatedTarget "A subdivision of spinal cord ventral column that is part of a sacral spinal cord." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005854 ; owl:annotatedTarget "A subdivision of spinal cord ventral column that is part of a cervical spinal cord." . [] oboInOwl:source "BIRNLEX:1660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005854 ; owl:annotatedTarget "UMLS:C0228619" . [] oboInOwl:source "BIRNLEX:1660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005854 ; owl:annotatedTarget "UMLS:C1278746" . [] oboInOwl:hasDbXref "BIRNLEX:1660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005854 ; owl:annotatedTarget "cervical spinal cord anterior column" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005855 ; owl:annotatedTarget "A subdivision of spinal cord ventral column that is part of a lumbar spinal cord." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005856 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005856 ; owl:annotatedTarget obo:UBERON_0011585 . [] oboInOwl:source "AEO-modified-relation" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005856 ; owl:annotatedTarget _:genid142288 . _:genid140861 oboInOwl:hasDbXref "AEO:0000148" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005856 ; owl:annotatedTarget "A delimited region of dense mesenchyme within looser mesenchyme." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010349 . [] oboInOwl:hasDbXref "EMAPA:25351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005856 ; owl:annotatedTarget "mesenchyme condensation" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget obo:UBERON_0005856 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget _:genid142293 . [] oboInOwl:hasDbXref "GO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget "isa cell condensation in VSAO; has_part chondroblast in AEO" . [] oboInOwl:hasDbXref "EMAPA:25353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget "cartilage condensation" . [] oboInOwl:hasDbXref "EHDAA2:0003147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget "cartilagenous condensation" . [] oboInOwl:hasDbXref "VSAO:0000092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005863 ; owl:annotatedTarget "chondrogenic condensation" . _:genid140873 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000680, obo:UBERON_0001694 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005865 ; owl:annotatedTarget _:genid142305 . _:genid140879 oboInOwl:source "AEO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005866 ; owl:annotatedTarget obo:UBERON_0005856 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003098 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005866 ; owl:annotatedTarget _:genid142310 . _:genid140881 oboInOwl:hasDbXref "AEO:0000150", "AEO:JB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005866 ; owl:annotatedTarget "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0016855 . [] oboInOwl:source "http://dictionary.reference.com/browse/precartilage" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005866 ; owl:annotatedTarget "A closely packed aggregation of mesenchymal cells just prior to their differentiation into embryonic cartilage." . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010939" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005867 ; owl:annotatedTarget "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip." . [] oboInOwl:source "ncithesaurus:Mandibular_Prominence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005867 ; owl:annotatedTarget "UMLS:C1512982" . [] oboInOwl:hasDbXref "Wikipedia:Mandibular_prominence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005867 ; owl:annotatedTarget "mandibular process" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005867 ; owl:annotatedTarget "mandibular swelling" . [] oboInOwl:hasDbXref "Wikipedia:Mandibular_prominence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005867 ; owl:annotatedTarget "prominentia mandibularis" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0010940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005868 ; owl:annotatedTarget "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw." . [] oboInOwl:source "ncithesaurus:Maxillary_Prominence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005868 ; owl:annotatedTarget "UMLS:C1513037" . [] oboInOwl:hasDbXref "EHDAA2:0001070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005868 ; owl:annotatedTarget "maxillary process" . [] oboInOwl:hasDbXref "Wikipedia:Maxillary_prominence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005868 ; owl:annotatedTarget "prominentia maxilaris" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget obo:UBERON_0016566 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget _:genid142329 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget _:genid142332 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "PMID:15277408" . [] oboInOwl:source "XAO:0000275 nasal pit" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget _:genid142334 . [] oboInOwl:hasDbXref "GO:0060166", "Wikipedia:Nasal_pit" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget "An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO]." . [] oboInOwl:source "Wikipedia:Nasal_pit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget "By the upgrowth of the surrounding parts the olfactory areas are converted into pits, the nasal pits or olfactory pits, which indent the fronto-nasal process and divide it into a medial and two lateral nasal processes[Wikipedia:Nasal_pit]." . [] oboInOwl:hasDbXref "XAO:0000275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005870 ; owl:annotatedTarget "nasal pit" . [] oboInOwl:hasDbXref "ISBN:0124020607", "VHOG:OG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "A groove that is situated between the 1st and 2nd pharyngeal arch." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000969" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.semcdb.2010.01.022 Grevellec A, Tucker AS, The pharyngeal pouches and clefts: development, evolution, structure and derivatives. Seminars in Cell and Developmental Biology (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "In all jawed vertebrates the first arch forms the jaw, while the second arch forms the hyoid apparatus. These two arches are separated by the first pharyngeal pouch and cleft.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000008" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st arch branchial groove" . [] oboInOwl:hasDbXref "EHDAA2:0000009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st arch groove ectoderm" . [] oboInOwl:hasDbXref "VHOG:0000969" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st pharyngeal groove" . [] oboInOwl:hasDbXref "VHOG:0000554" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st pharyngeal groove ectoderm" . [] oboInOwl:hasDbXref "EMAPA:16119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "branchial groove of 1st arch" . [] oboInOwl:hasDbXref "EMAPA:16119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st branchial cleft" . [] oboInOwl:hasDbXref "VHOG:0000969" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005872 ; owl:annotatedTarget "1st pharyngeal cleft" . [] oboInOwl:hasDbXref "ISBN:0124020607", "VHOG:OG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "A groove that is situated between the 2nd and 3rd pharyngeal arch." . [] oboInOwl:hasDbXref "EHDAA2:0000054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd arch branchial groove" . [] oboInOwl:hasDbXref "EHDAA2:0000057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd arch groove ectoderm" . [] oboInOwl:hasDbXref "VHOG:0000972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd pharyngeal groove" . [] oboInOwl:hasDbXref "VHOG:0000568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd pharyngeal groove ectoderm" . [] oboInOwl:hasDbXref "EMAPA:16396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "branchial groove of 2nd arch" . [] oboInOwl:hasDbXref "EMAPA:16396" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd branchial cleft" . [] oboInOwl:hasDbXref "VHOG:0000972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005873 ; owl:annotatedTarget "2nd pharyngeal cleft" . [] oboInOwl:hasDbXref "ISBN:0124020607", "VHOG:OG" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "A groove that is situated between the 3rd and 4th pharyngeal arch." . [] oboInOwl:hasDbXref "EHDAA2:0000071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd arch branchial groove" . [] oboInOwl:hasDbXref "EHDAA2:0000074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd arch groove ectoderm" . [] oboInOwl:hasDbXref "VHOG:0000973" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd pharyngeal groove" . _:genid140943 oboInOwl:hasDbXref "VHOG:0000572" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd pharyngeal groove ectoderm" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:hasDbXref "EMAPA:16581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "branchial groove of 3rd arch" . [] oboInOwl:hasDbXref "EMAPA:16581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd branchial cleft" . [] oboInOwl:hasDbXref "VHOG:0000973" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005874 ; owl:annotatedTarget "3rd pharyngeal cleft" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget _:genid142382 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011771", "https://github.com/obophenotype/uberon/issues/1230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000583" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/genital+tubercle" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "The eminence in the embryo which develops into the clitoris or penis. [TFD][VHOG]" . [] oboInOwl:ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until ~E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000583" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1242/dev.036830 Seifert AW, Yamaguchi T, Cohn MJ, Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "In mammalian embryos, male and female external genitalia develop from the genital tubercle.[well established][VHOG]" . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "we assume the EMAPA class is the undifferentiated form based on TS timings" . [] oboInOwl:hasDbXref "VHOG:0000583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "undifferentiated genital tubercle" . [] oboInOwl:hasDbXref "EMAPA:17382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "genital tubercle" . [] oboInOwl:hasDbXref "Wikipedia:Genital_tubercle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "tuberculum genitale" . [] oboInOwl:hasDbXref "Wikipedia:Genital_tubercle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005876 ; owl:annotatedTarget "tuberculum phallicum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000980 ; owl:annotatedTarget obo:CL_0000785 . _:genid140962 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget obo:UBERON_0006846 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003371 . [] oboInOwl:source "EHDAA2-adbuced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget _:genid142396 . [] oboInOwl:hasDbXref "PMID:23020903", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "EMAPA distinguishes between the groove ectoderm and epithelium, with the latter arising after the former" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "pharyngeal groove" . [] oboInOwl:source "ncithesaurus:Pharyngeal_Groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "UMLS:C1280559" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "pharyngeal groove ectoderm" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "branchial cleft" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2673126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000980 ; owl:annotatedTarget "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." . [] oboInOwl:hasDbXref "AAO:0010623", "Wikipedia:Pharyngeal_groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "branchial groove" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "pharyngeal slit" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_groove" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005879 ; owl:annotatedTarget "sulcus pharyngei" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005881 ; owl:annotatedTarget "A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget _:genid142412 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget _:genid142414 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "A subdivision of skeleton that supports pharyngeal arch 2." . [] oboInOwl:external_ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "it's not clear where AAO:'hyobranchial skeleton' belongs" . [] oboInOwl:hasDbXref "ZFA:0001276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "hyoid arch skeleton" . [] oboInOwl:hasDbXref "ZFA:0001276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "pharyngeal arch 2 skeleton" . [] oboInOwl:hasDbXref "TAO:0001276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "hyoid bars" . [] oboInOwl:hasDbXref "TAO:0001276" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "hyoid arch" . [] oboInOwl:hasDbXref "TAO:0001276" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005884 ; owl:annotatedTarget "visceral arch 2" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005891 ; owl:annotatedTarget _:genid142425 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005891 ; owl:annotatedTarget _:genid142427 . [] oboInOwl:hasDbXref "Wikipedia:Coelomic_epithelium", "XAO:0000329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005891 ; owl:annotatedTarget "The epithelial lining of the surface of the coelom." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0005891 ; owl:annotatedTarget "EHDAA2:0004049 used to be called 'coelomic epithelium' but is now 'gonadal ridge mesothelium'" . [] oboInOwl:hasDbXref "Wikipedia:Coelomic_epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005891 ; owl:annotatedTarget "germinal epithelium of Waldeyer" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005893 ; owl:annotatedTarget "A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005893 ; owl:annotatedTarget "EMAPA:37304" . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002329 ; owl:annotatedTarget (obo:BFO_0000050 obo:RO_0002215 ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "PMID:18492944" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005897 ; owl:annotatedTarget "A bone that is part of the manus skeleton. Note that this includes the carpal bones." . [] oboInOwl:hasDbXref "MA:0000619" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005897 ; owl:annotatedTarget "hand bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005899 ; owl:annotatedTarget "A bone that is part of the pes skeleton." . [] oboInOwl:source "ncithesaurus:Foot_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005899 ; owl:annotatedTarget "UMLS:C0016505" . [] oboInOwl:hasDbXref "MA:0000643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005899 ; owl:annotatedTarget "foot bone" . [] oboInOwl:hasDbXref "TAO:0001414", "UBERONREF:0000007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles." . _:genid141014 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010199" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "An anatomical cluster that is located in the posterior region of the neurocranium and forms the margin of the foramen margin and occipital condyles.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001414" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occiptal condyle.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001414" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "basicranial region" . [] oboInOwl:hasDbXref "FMA:49187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "occipital part of head" . [] oboInOwl:hasDbXref "FMA:49187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "occipital region of head" . [] oboInOwl:hasDbXref "FMA:49187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005902 ; owl:annotatedTarget "back of head" . [] oboInOwl:hasDbXref "Wikipedia:Excretory_duct_of_seminal_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP]." . _:genid141027 oboInOwl:hasDbXref "FMA:19473" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "ductus excretorius (vesicula seminalis)" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001650 . [] oboInOwl:hasDbXref "FMA:19473", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "ductus excretorius glandulae vesiculosae" . [] oboInOwl:hasDbXref "FMA:19473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "excretory duct of seminal gland" . [] oboInOwl:hasDbXref "FMA:19473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "seminal vesicle duct" . [] oboInOwl:hasDbXref "Wikipedia:Excretory_duct_of_seminal_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005903 ; owl:annotatedTarget "ductus excretorius glandulae vesiculosae" . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005904 ; owl:annotatedTarget "Any of the ducts that are part of a male reproductive system." . [] oboInOwl:hasDbXref "FMA:9689", "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005906 ; owl:annotatedTarget "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000981 ; owl:annotatedTarget obo:CL_0000787 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget obo:UBERON_0005906 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget _:genid142482 . [] oboInOwl:source "HPO:pr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget _:genid142484 . [] oboInOwl:modified_from "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget _:genid142486 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Serous-Membranes-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget "A serous sac which is the aggregate of the conjunctiva plus the conjunctival space." . [] oboInOwl:hasDbXref "NCBITaxon:8570" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005908 ; owl:annotatedTarget "subbrillar sac" . [] oboInOwl:hasDbXref "GOC:msz", "GOC:tfm", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000981 ; owl:annotatedTarget "A memory B cell with the phenotype IgD-negative and CD27-negative." . [] oboInOwl:hasDbXref "FMA:69065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005911 ; owl:annotatedTarget "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005913 ; owl:annotatedTarget obo:UBERON_0034944 . [] oboInOwl:hasDbXref "FMA:10483" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005913 ; owl:annotatedTarget "bone organ zone" . _:genid141059 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004145, obo:UBERON_0013514 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget obo:UBERON_0003102 . _:genid141065 oboInOwl:hasDbXref "Wikipedia:Nostril", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "A naris that provides one of the small external openings of the head that give passage to air for breathing." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003123 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000024" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "Hole on the nasal capsule that connects the nasal cavity with the exterior.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000024" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "relationship loss: subclass nasal opening (AAO:0000316)[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000544" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.257 and Figure 7.27", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "In a tetrapod, the nasal sac has an external naris (homologous with the anterior naris of the fish) (...).[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0000550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "naris" . [] oboInOwl:source "ncithesaurus:Nostril" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "UMLS:C0595944" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "external nares" . [] oboInOwl:hasDbXref "FMA:59645", "XAO:0003033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "nostril" . [] oboInOwl:hasDbXref "Wikipedia:Blowhole_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "blowhole" . [] oboInOwl:hasDbXref "VHOG:0000544" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "anterior nares" . [] oboInOwl:hasDbXref "ZFA:0001427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005928 ; owl:annotatedTarget "anterior naris" . [] oboInOwl:hasDbXref "FMA:71221", "VSAO:0000056", "Wikipedia:Axial_skeleton", "https://github.com/obophenotype/uberon/issues/44", "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005944 ; owl:annotatedTarget "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000056" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005944 ; owl:annotatedTarget "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" . [] oboInOwl:source "ncithesaurus:Axial_Skeleton" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005944 ; owl:annotatedTarget "UMLS:C0222645" . [] oboInOwl:hasDbXref "Wikipedia:Axial_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005944 ; owl:annotatedTarget "skeleton axiale" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget obo:UBERON_0003932 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget _:genid142529 . _:genid141086 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget _:genid142531 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003727 . [] oboInOwl:hasDbXref "ZFA:0001321" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget "trabecula" . [] oboInOwl:hasDbXref "ZFA:0001321" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget "trabecular cartilage" . _:genid141089 oboInOwl:hasDbXref "ZFA:0001321" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005945 ; owl:annotatedTarget "neurocranial trabeculae" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0006204 . (obo:UBERON_0004145 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002081 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005946 ; owl:annotatedTarget "An outflow tract that is part of a cardiac atrium." . [] oboInOwl:hasDbXref "FMA:14141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005946 ; owl:annotatedTarget "outflow part of atrium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "PMID:19796288" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000982 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:source "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget _:genid142548 . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk." . [] oboInOwl:hasDbXref "Wikipedia:Conus_arteriosus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "infundibulum" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "EMAPA:37926" . [] oboInOwl:source "ncithesaurus:Infundibulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "UMLS:C1881209" . [] oboInOwl:hasDbXref "MP:0010428" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "RVOT" . [] oboInOwl:hasDbXref "FMA:7216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "conus arteriosus (infundibulum)" . [] oboInOwl:hasDbXref "FMA:7216", "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "infundibulum of right ventricle" . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000982 ; owl:annotatedTarget "A plasmablast that secretes IgG." . [] oboInOwl:hasDbXref "FMA:7216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "outflow tract of right ventricle" . [] oboInOwl:hasDbXref "FMA:7216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "pulmonary conus" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "right ventricle pulmonary outflow tract" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "right ventricular outflow tract" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "arterial cone" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "conus arteriosus" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "pulmonary cone" . [] oboInOwl:hasDbXref "MP:0010428" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005953 ; owl:annotatedTarget "pulmonary conus" . [] oboInOwl:hasDbXref "MP:0010429" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "EMAPA:37925" . [] oboInOwl:hasDbXref "MP:0010429" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "LVOT" . [] oboInOwl:hasDbXref "MP:0010429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "Sibson vestibule" . [] oboInOwl:hasDbXref "FMA:9473", "MP:0010429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "aortic vestibule" . [] oboInOwl:hasDbXref "MP:0010429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "heart left ventricle outflow tract" . [] oboInOwl:hasDbXref "FMA:9473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "left ventricular outflow" . [] oboInOwl:hasDbXref "HP:0011103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "left ventricular outflow tract" . [] oboInOwl:hasDbXref "FMA:9473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "outflow tract of left ventricle" . [] oboInOwl:hasDbXref "FMA:9473", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005956 ; owl:annotatedTarget "vestibulum aortae" . [] oboInOwl:hasDbXref "FMA:9550", "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005965 ; owl:annotatedTarget "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]." . [] oboInOwl:hasDbXref "FMA:9550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005965 ; owl:annotatedTarget "main part of right atrium" . [] oboInOwl:hasDbXref "FMA:9550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005965 ; owl:annotatedTarget "outflow tract of right atrium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005966 ; owl:annotatedTarget "An outflow tract of atrium that is part of a left atrium." . [] oboInOwl:hasDbXref "FMA:9551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005966 ; owl:annotatedTarget "main part of left atrium" . [] oboInOwl:hasDbXref "FMA:9551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005966 ; owl:annotatedTarget "outflow tract of left atrium" . [] oboInOwl:hasDbXref "MP:0005203", "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP]." . [] oboInOwl:source "ncithesaurus:Trabecular_Meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "UMLS:C0040573" . [] oboInOwl:hasDbXref "MA:0003086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "eye trabecular meshwork" . _:genid141154 oboInOwl:hasDbXref "BTO:0001605" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "reticulum trabeculare" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0006204 . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "trabecular meshwork of the eye" . _:genid141156 oboInOwl:hasDbXref "BTO:0001605" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "Hueck's ligament" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002207 . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "cribiform ligament" . _:genid141158 oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "iridis" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002228 . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "ligamentum peactin-tum iridis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000983 ; owl:annotatedTarget obo:CL_0000980 . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "ligamentum pectinatum" . [] oboInOwl:hasDbXref "BTO:0001605" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "ligamentum pectinatum anguli iridocornealis" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "ligamentum pectinatum iridis" . [] oboInOwl:hasDbXref "BTO:0001605" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "pectinate ligament" . [] oboInOwl:hasDbXref "BTO:0001605" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "pectinate ligament of iris" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "reticulum trabeculare sclerae" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "scleral trabeculae" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "scleral trabecular" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "scleral trabecule" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "scribiform ligament" . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000983 ; owl:annotatedTarget "A plasmablast that secretes IgM." . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_meshwork" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "trabecular mesh" . [] oboInOwl:hasDbXref "BTO:0001605", "GO:0002930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005969 ; owl:annotatedTarget "trabecular meshwork" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:csmith", "MP:0002199", "https://github.com/obophenotype/uberon/issues/325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005970 ; owl:annotatedTarget "Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain." . [] oboInOwl:date_retrieved "2012-08-08" ; oboInOwl:external_class "MP:0002199" ; oboInOwl:ontology "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0005970 ; owl:annotatedTarget "any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain[MP]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005970 ; owl:annotatedTarget "EMAPA:37446" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005971 ; owl:annotatedTarget _:genid142627 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005971 ; owl:annotatedTarget "A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong]." . [] oboInOwl:hasDbXref "http://placentation.ucsd.edu/glossfs.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005971 ; owl:annotatedTarget "amnionic fold" . [] oboInOwl:hasDbXref "MP:0010495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005979 ; owl:annotatedTarget "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005979 ; owl:annotatedTarget "EMAPA:37837" . [] oboInOwl:hasDbXref "FMA:9236", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005979 ; owl:annotatedTarget "crista terminalis atrii dextri" . [] oboInOwl:hasDbXref "FMA:9236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005979 ; owl:annotatedTarget "crista terminalis cordis" . [] oboInOwl:hasDbXref "FMA:9236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005979 ; owl:annotatedTarget "crista terminalis of right atrium" . [] oboInOwl:hasDbXref "MP:0010545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005983 ; owl:annotatedTarget "The laminar structure of the heart." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "Reaxys:80736" . [] oboInOwl:hasDbXref "MP:0010551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005985 ; owl:annotatedTarget "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005988 ; owl:annotatedTarget _:genid142654 . [] oboInOwl:hasDbXref "MP:0010581", "ZFA:0005810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005988 ; owl:annotatedTarget "The supporting bundles of muscular fibers lining the walls of the atrial myocardium." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005988 ; owl:annotatedTarget "EMAPA:37432" . [] oboInOwl:hasDbXref "MP:0010581" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005988 ; owl:annotatedTarget "atrium myocardial trabeculae" . [] oboInOwl:hasDbXref "ZFA:0005810" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005988 ; owl:annotatedTarget "trabecular layer of the atrium" . _:genid141214 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002078, obo:UBERON_0008713 . _:genid141216 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002084, obo:UBERON_0013700 . _:genid141218 oboInOwl:source "PMID:15797462", "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005989 ; owl:annotatedTarget _:genid142667 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000962 . [] oboInOwl:hasDbXref "MP:0010592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005989 ; owl:annotatedTarget "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000984 ; owl:annotatedTarget obo:CL_0000980 . _:genid141220 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005989 ; owl:annotatedTarget "EMAPA:37431" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010983 . [] oboInOwl:hasDbXref "FMA:7136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005989 ; owl:annotatedTarget "membranous atrioventricular septum" . _:genid141222 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006009 _:genid141224 ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001077 . _:genid141224 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0002137, obo:UBERON_0007174 . [] oboInOwl:hasDbXref "MP:0010595" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005990 ; owl:annotatedTarget "The three fibrous triangular components and associated flap of the aortic valve." . [] oboInOwl:hasDbXref "FMA:7251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005990 ; owl:annotatedTarget "aortic semilunar valvule" . [] oboInOwl:hasDbXref "FMA:7251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005990 ; owl:annotatedTarget "aortic valvular cusp" . [] oboInOwl:hasDbXref "GOC:msz", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000984 ; owl:annotatedTarget "A plasmablast that secretes IgA." . [] oboInOwl:hasDbXref "FMA:7251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005990 ; owl:annotatedTarget "cusp of aortic valve" . [] oboInOwl:hasDbXref "FMA:7251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005990 ; owl:annotatedTarget "semilunar valvule of aortic valve" . (obo:UBERON_0006008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002137 ] ) . [] oboInOwl:hasDbXref "MP:0010598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "The fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "EMAPA:37418" . [] oboInOwl:hasDbXref "FMA:9502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "anulus of aortic valve" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000988 ; owl:annotatedTarget "A cell of a hematopoietic lineage." . [] oboInOwl:hasDbXref "FMA:9502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "aortic anulus" . [] oboInOwl:hasDbXref "FMA:9502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "aortic valvar anulus" . [] oboInOwl:hasDbXref "FMA:9502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005991 ; owl:annotatedTarget "fibrous ring of aortic valve" . [] oboInOwl:hasDbXref "MP:0010602" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "The three fibrous triangular components and associated flap of the pulmonary valve." . [] oboInOwl:hasDbXref "FMA:7248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "cusp of pulmonary valve" . [] oboInOwl:hasDbXref "FMA:7248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "pulmonary semilunar valvule" . [] oboInOwl:hasDbXref "FMA:7248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "pulmonary valvular cusp" . [] oboInOwl:hasDbXref "FMA:7248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "semilunar cusp of pulmonary valve" . [] oboInOwl:hasDbXref "FMA:7248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005992 ; owl:annotatedTarget "semilunar valvule of pulmonary valve" . [] oboInOwl:hasDbXref "MP:0010606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "The fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "EMAPA:37420" . [] oboInOwl:hasDbXref "FMA:9503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "anulus of pulmonary valve" . [] oboInOwl:hasDbXref "FMA:9503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "fibrous ring of pulmonary valve" . [] oboInOwl:hasDbXref "FMA:9503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "pulmonary anulus" . [] oboInOwl:hasDbXref "FMA:9503" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005993 ; owl:annotatedTarget "pulmonary valvar anulus" . [] oboInOwl:source "FMA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005994 ; owl:annotatedTarget _:genid142716 . [] oboInOwl:hasDbXref "MP:0010608", "Wikipedia:Chordae_tendineae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005994 ; owl:annotatedTarget "The tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria." . [] oboInOwl:source "ncithesaurus:Chordae_Tendineae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005994 ; owl:annotatedTarget "UMLS:C0008484" . [] oboInOwl:hasDbXref "FMA:12225" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005994 ; owl:annotatedTarget "chordae tendinea" . [] oboInOwl:hasDbXref "Wikipedia:Chordae_tendineae" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0005994 ; owl:annotatedTarget "chordae tendineae cordis" . _:genid141272 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006008 _:genid141274 _:genid141276 ) ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000962 . _:genid141274 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002135, obo:UBERON_0003066 . _:genid141276 a owl:Restriction ; owl:onProperty obo:RO_0002371, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0000165, obo:UBERON_0005996 . _:genid141278 a owl:Restriction ; owl:onProperty obo:RO_0002373, obo:RO_0002433 ; owl:someValuesFrom obo:UBERON_0002135, obo:UBERON_0010933 . [] oboInOwl:hasDbXref "MP:0010613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "The fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "EMAPA:37419" . [] oboInOwl:hasDbXref "FMA:9498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "anulus of mitral valve" . [] oboInOwl:hasDbXref "FMA:9498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "fibrous ring of mitral valve" . [] oboInOwl:hasDbXref "Wikipedia:Mitral_annulus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "mitral annulus" . [] oboInOwl:hasDbXref "FMA:9498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "mitral anulus" . [] oboInOwl:hasDbXref "FMA:9498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005995 ; owl:annotatedTarget "mitral valvar anulus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0000990 ; owl:annotatedTarget obo:CL_0000451 . [] oboInOwl:hasDbXref "MP:0010614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005996 ; owl:annotatedTarget "The two fibrous components and associated flaps of the mitral valve." . [] oboInOwl:hasDbXref "MP:0010621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "The fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "EMAPA:37421" . [] oboInOwl:hasDbXref "FMA:9500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "anulus of tricuspid valve" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "(2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol" . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:17850486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0000990 ; owl:annotatedTarget "Conventional dendritic cell is a dendritic cell that is CD11c-high." . [] oboInOwl:hasDbXref "FMA:9500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "fibrous ring of tricuspid valve" . [] oboInOwl:hasDbXref "FMA:9500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "tricuspid anulus" . [] oboInOwl:hasDbXref "FMA:9500" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005997 ; owl:annotatedTarget "tricuspid valvar anulus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget obo:UBERON_0005484 . [] oboInOwl:hasDbXref "MP:0010622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "The three fibrous triangular components and associated flaps of the tricuspid valve." . [] oboInOwl:hasDbXref "FMA:7240", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "cuspis septalis (valva tricuspidalis)" . [] oboInOwl:hasDbXref "FMA:7240", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "cuspis septalis valvae atrioventricularis dextrae" . [] oboInOwl:hasDbXref "FMA:7240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "septal cusp of right atrioventricular valve" . _:genid141313 oboInOwl:hasDbXref "FMA:7240" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "septal cusp of tricuspid valve" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001586 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "septal leaflet of right-sided tricuspid valve" . [] oboInOwl:hasDbXref "FMA:7240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "septal leaflet of tricuspid valve" . [] oboInOwl:hasDbXref "FMA:7240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0005998 ; owl:annotatedTarget "septal tricuspid leaflet" . [] oboInOwl:notes "ventral branch" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006002 ; owl:annotatedTarget _:genid142772 . [] oboInOwl:hasDbXref "MP:0010664", "Wikipedia:Vitelline_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006002 ; owl:annotatedTarget "The paired arteries that carry blood to the yolk sac from the dorsal aorta." . [] oboInOwl:hasDbXref "http://code.google.com/p/caro2/issues/detail?id=5", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." . [] oboInOwl:source "MP:0010678" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678]" . _:genid141326 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "EMAPA:37883" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005496 . [] oboInOwl:hasDbXref "GO:GO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "body hair or bristle" . [] oboInOwl:hasDbXref "Wikipedia:Skin_appendage" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "adnexae cutis" . [] oboInOwl:hasDbXref "Wikipedia:Skin_appendage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "skin adnexa" . [] oboInOwl:hasDbXref "Wikipedia:Skin_appendage" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006003 ; owl:annotatedTarget "skin appendage" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_rings_of_heart", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "EMAPA:37422" . [] oboInOwl:hasDbXref "FMA:9497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "anulus fibrosus of heart" . [] oboInOwl:hasDbXref "BTO:0003628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "Lower's ring" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_rings_of_heart" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "annulus fibrosus cordis" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_rings_of_heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "anulus fibrosus cordis" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_rings_of_heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "aortic annulus" . [] oboInOwl:hasDbXref "BTO:0003628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "atrioventricular ring" . [] oboInOwl:hasDbXref "BTO:0003628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "coronary tendon" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_rings_of_heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006008 ; owl:annotatedTarget "fibrous ring of heart" . [] oboInOwl:hasDbXref "Wikipedia:Cusps_of_heart_valves" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "The part of the heart valves that serves to seal the heart valves when closed. There are three cusps for each valve except for the mitral valve, which has only two (hence its alternate name, 'bicuspid valve'). 'Nodules' are located at the tip of the valve, to form a tighter seal[WP]." . [] oboInOwl:source "ncithesaurus:Cardiac_Valve_Cusp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "UMLS:C0225923" . [] oboInOwl:hasDbXref "FMA:7232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "cardiac valve cusp" . [] oboInOwl:hasDbXref "FMA:7232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "cardiac valvular cusp" . [] oboInOwl:hasDbXref "FMA:7232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "cardiac valvule" . [] oboInOwl:hasDbXref "FMA:7232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006009 ; owl:annotatedTarget "semilunar valvule" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget _:genid142806 . _:genid141355 oboInOwl:hasDbXref "Wikipedia:Hyaloid_canal" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget "A small transparent canal running through the vitreous body from the optical nerve disc to the lens. It is formed by an invagination of the hyaloid, a membrane which encloses the vitreous body[WP]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003711 . [] oboInOwl:hasDbXref "FMA:58837", "Wikipedia:Hyaloid_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget "Cloquet's canal" . [] oboInOwl:hasDbXref "FMA:58837", "Wikipedia:Hyaloid_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget "Stilling's canal" . [] oboInOwl:hasDbXref "FMA:58837" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget "canal of Cloquet" . [] oboInOwl:hasDbXref "Wikipedia:Hyaloid_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006010 ; owl:annotatedTarget "canalis hyaloideus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006048 ; owl:annotatedTarget "A digit that is part of a digit 1 plus metapodial segment." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006048 ; owl:annotatedTarget "EMAPA:37285" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006048 ; owl:annotatedTarget "digit I" . [] oboInOwl:hasDbXref "MA:0003023" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006048 ; owl:annotatedTarget "limb digit 1" . [] oboInOwl:hasDbXref "Wikipedia:Dewclaw" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006048 ; owl:annotatedTarget "dewclaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006049 ; owl:annotatedTarget "A digit that is part of a digit 2 plus metapodial segment." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006049 ; owl:annotatedTarget "EMAPA:37286" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006049 ; owl:annotatedTarget "digit II" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006050 ; owl:annotatedTarget "A digit that is part of a digit 3 plus metapodial segment." . _:genid141382 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006050 ; owl:annotatedTarget "EMAPA:37287" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002203 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006050 ; owl:annotatedTarget "digit III" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006051 ; owl:annotatedTarget "A digit that is part of a digit 4 plus metapodial segment." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006051 ; owl:annotatedTarget "EMAPA:37288" . _:genid141390 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006051 ; owl:annotatedTarget "digit IV" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004467 . (obo:UBERON_0002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006052 ] ) . _:genid141395 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006052 ; owl:annotatedTarget "A digit that is part of a digit 5 plus metapodial segment." ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002036 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006052 ; owl:annotatedTarget "EMAPA:37289" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006052 ; owl:annotatedTarget "digit V" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-Anhydro-D-glucitol" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006058 ; owl:annotatedTarget "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." . _:genid141405 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924, obo:UBERON_0002363 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006059 ; owl:annotatedTarget _:genid142859 . [] oboInOwl:hasDbXref "Wikipedia:Falx_cerebri" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006059 ; owl:annotatedTarget "The falx cerebri, also known as the cerebral falx, so named from its sickle-like form, is a strong, arched fold of dura mater which descends vertically in the longitudinal fissure between the cerebral hemispheres. It is narrow in front, where it is attached to the crista galli of the ethmoid; and broad behind, where it is connected with the upper surface of the tentorium cerebelli. Its upper margin is convex, and attached to the inner surface of the skull in the middle line, as far back as the internal occipital protuberance; it contains the superior sagittal sinus. Its lower margin is free and concave, and contains the inferior sagittal sinus. The falx cerebri is known to calcify with age." . [] oboInOwl:source "ncithesaurus:Falx_Cerebri" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006059 ; owl:annotatedTarget "UMLS:C0228120" . [] oboInOwl:hasDbXref "FMA:83967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006059 ; owl:annotatedTarget "cerebral falx" . [] oboInOwl:hasDbXref "Wikipedia:Vertebral_column#Structure_of_individual_vertebrae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006061 ; owl:annotatedTarget "A process projection from a part of the vertebra such as centrum or arches. Examples: transverse process, diapophyses, parapophyses, and zygapophyses (both the cranial zygapophyses and the caudal zygapophyses)." . [] oboInOwl:hasDbXref "FMA:24530" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006061 ; owl:annotatedTarget "vertebral process" . [] oboInOwl:hasDbXref "AAO:0000739" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006061 ; owl:annotatedTarget "spinous process" . _:genid141414 a owl:Restriction ; owl:onProperty obo:BSPO_0000126, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002412, obo:UBERON_0004291 . [] oboInOwl:hasDbXref "AAO:Pugener_and_Maglia_2008", "Wikipedia:Articular_processes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region[AAO]. The articular processes or zygapophyses of a vertebra, in human anatomy contain two superior and two inferior, spring from the junctions of the pedicles and laminae. These stick out of an end of a vertebra to lock with a zygapophysis on the next vertebra, to make the backbone more stable. The superior processes project upward from a lower vertebra, and their articular surfaces are directed more or less backward. The inferior processes project downward from a higher vertebra, and their articular surfaces are directed more or less forward and outward. The articular surfaces are coated with hyaline cartilage." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000710" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Pugener_and_Maglia_2008" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region.[AAO]" . [] oboInOwl:hasDbXref "Wikipedia:Articular_processes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "articular process" . [] oboInOwl:hasDbXref "FMA:11952" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "articular process of vertebra" . _:genid141419 oboInOwl:hasDbXref "FMA:11952" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "processus articularis (zygapophysis)" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007289 . [] oboInOwl:hasDbXref "Wikipedia:Articular_processes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "zygapophysis" . [] oboInOwl:hasDbXref "TAO:0001549" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "intercalarium articulating process" . [] oboInOwl:hasDbXref "Wikipedia:Articular_processes" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "p. articularis vertebrae" . [] oboInOwl:hasDbXref "Wikipedia:Articular_processes" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006062 ; owl:annotatedTarget "processus articularis vertebrae" . [] oboInOwl:hasDbXref "BTO:0001763" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006063 ; owl:annotatedTarget "One of the cartilaginous structures surrounding the embryonic spinal cord, formed by the dorsal growth of the dorsolateral arcualia; it is the primordium of the vertebral arch." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006067 ; owl:annotatedTarget "Any collection of muscles that is part of a hindlimb zeugopod." . [] oboInOwl:hasDbXref "FMA:50211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006067 ; owl:annotatedTarget "leg musculature" . [] oboInOwl:hasDbXref "FMA:50211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006067 ; owl:annotatedTarget "muscle group of leg" . [] oboInOwl:hasDbXref "FMA:50211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006067 ; owl:annotatedTarget "set of muscles of leg" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006068 ; owl:annotatedTarget "A bone that is part of a post-anal tail." . _:genid141440 oboInOwl:external_ontology "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006068 ; owl:annotatedTarget "MA has distinct classes for 'tail bone', 'caudal vertebra' and 'coccygeal vertebra' but these may all be equivalent. This class may be obsoleted in future." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002405 . [] oboInOwl:hasDbXref "MA:0000696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006068 ; owl:annotatedTarget "tail bone" . _:genid141442 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006068 ; owl:annotatedTarget "tail vertebra" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003295 . _:genid141444 a owl:Restriction ; owl:onProperty obo:BSPO_0000099, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001245, obo:UBERON_0007690 . _:genid141446 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0005428 . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "post-anal caudal region" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "post-anal tail region" . [] oboInOwl:hasDbXref "AAO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "postsacral region" . [] oboInOwl:hasDbXref "AAO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006071 ; owl:annotatedTarget "tail region" . _:genid141456 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090, obo:UBERON_0007213 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget _:genid142911 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "That portion of the spine comprising the cervical vertebrae. The neck area of the spine." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000092" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "Anterior region of the vertebral column consisting of one to 19 or 20 vertebrae.[AAO]" . [] oboInOwl:source "ncithesaurus:Cervical_Spine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "UMLS:C0728985" . _:genid141461 oboInOwl:hasDbXref "MA:0003154" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "axial skeleton cervical region" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000990 . [] oboInOwl:hasDbXref "EHDAA2:0000238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "cervical skeleton" . [] oboInOwl:hasDbXref "FMA:24138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "cervical spinal column" . [] oboInOwl:hasDbXref "FMA:24138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "cervical spine" . [] oboInOwl:hasDbXref "FMA:24138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "cervical vertebral column" . [] oboInOwl:hasDbXref "FMA:24138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006072 ; owl:annotatedTarget "skeletal system of neck" . _:genid141472 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget _:genid142926 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003849 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "That part of the spine comprising the thoracic vertebrae." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000612" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" . [] oboInOwl:source "ncithesaurus:Thoracic_Spine" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "UMLS:C0581269" . [] oboInOwl:hasDbXref "MA:0003155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "axial skeleton thoracic region" . [] oboInOwl:hasDbXref "FMA:9140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "columna vertebralis thoracicus" . [] oboInOwl:hasDbXref "FMA:9140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "thoracic spine" . [] oboInOwl:hasDbXref "FMA:9140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006073 ; owl:annotatedTarget "thoracic vertebral column" . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006074 ; owl:annotatedTarget "Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae." . [] oboInOwl:hasDbXref "MA:0003156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006074 ; owl:annotatedTarget "axial skeleton lumbar region" . [] oboInOwl:hasDbXref "EHDAA2:0001037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006074 ; owl:annotatedTarget "lumbar skeleton" . [] oboInOwl:hasDbXref "BTO:0004147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006074 ; owl:annotatedTarget "lumbar spine" . [] oboInOwl:hasDbXref "FMA:16203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006074 ; owl:annotatedTarget "lumbar vertebral column" . _:genid141493 a owl:Restriction ; owl:onProperty obo:BFO_0000050, core:subdivision_of ; owl:someValuesFrom obo:UBERON_0005473, obo:UBERON_0009617 . _:genid141495 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002090, obo:UBERON_0009617 . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006075 ; owl:annotatedTarget "Subdivision of vertebral column that corresponds to the sacral subdivision of the body, containing the sacral vertebrae or sacrum." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000724" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006075 ; owl:annotatedTarget "Region of the vertebral column represented by one or two vertebrae.[AAO]" . [] oboInOwl:hasDbXref "MA:0003157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006075 ; owl:annotatedTarget "axial skeleton sacral region" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-anhydro-D-glucitol" . [] oboInOwl:hasDbXref "EHDAA2:0001772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006075 ; owl:annotatedTarget "sacral skeleton" . ( ) . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000082" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "Region of the vertebral column posterior to the caudal-sacral region, that may consists of two or three to more than 100 vertebrae. These vertebrae exhibit a gradual reduction in the sizes of their transverse processes and zygapophyses, but these structures are never entirely absent. All caudal vertebrae bear haemal arches.[AAO]" . [] oboInOwl:external_ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "in AAO, this is posterior to the caudal-sacral region" . [] oboInOwl:hasDbXref "MA:0003158" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "axial skeleton tail region" . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "caudal skeleton" . [] oboInOwl:hasDbXref "http://purl.bioontology.org/ontology/provisional/a047a2d5-418f-4d9c-ad21-ee0b7c29c29d" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "caudal vertebrae series" . [] oboInOwl:hasDbXref "AAO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "caudal region" . [] oboInOwl:hasDbXref "AAO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "postsacral region" . [] oboInOwl:hasDbXref "AAO:0000082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006076 ; owl:annotatedTarget "tail region" . (obo:UBERON_0000075 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0001130 ] ) . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006077 ; owl:annotatedTarget _:genid142977 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006077 ; owl:annotatedTarget "A collection of all skeletal elements in some subdivision of the vertebral column." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006077 ; owl:annotatedTarget "subdivision of vertebral skeleton" . [] oboInOwl:hasDbXref "FMA:16201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006077 ; owl:annotatedTarget "vertebral column subdivision" . _:genid141525 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002743, obo:UBERON_0003703 . [] oboInOwl:hasDbXref "BIRNLEX:1629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "The deep nuclei of telencephalic origin found in the basal region of the forebrain." . _:genid141527 oboInOwl:source "BIRNLEX:1629" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "UMLS:C0004781" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005171 . [] oboInOwl:source "BIRNLEX:1629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "neuronames:224" . [] oboInOwl:hasDbXref "BIRNLEX:1629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "basal nuclei" . [] oboInOwl:hasDbXref "BIRNLEX:1629" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "basal nuclei of the forebrain" . [] oboInOwl:hasDbXref "BIRNLEX:1629" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "basal ganglia" . [] oboInOwl:hasDbXref "NeuroNames:224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "basal ganglia (anatomic)" . [] oboInOwl:hasDbXref "NeuroNames:224" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "corpus striatum (Savel'ev)" . [] oboInOwl:hasDbXref "NeuroNames:224" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006098 ; owl:annotatedTarget "ganglia basales" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006127 ; owl:annotatedTarget "A funiculus of neuraxis that is part of a spinal cord." . [] oboInOwl:hasDbXref "FMA:77460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006127 ; owl:annotatedTarget "spinal cord funiculus" . [] oboInOwl:hasDbXref "FMA:77460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006127 ; owl:annotatedTarget "white column of spinal cord" . [] oboInOwl:hasDbXref "Wikipedia:Funiculus_(neurology)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006133 ; owl:annotatedTarget "The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans." . [] oboInOwl:hasDbXref "Wikipedia:Nervous_system_fiber" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system." . [] oboInOwl:hasDbXref "FMA:5914" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "nerve fibre" . [] oboInOwl:hasDbXref "FMA:5914", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "neurofibra" . [] oboInOwl:hasDbXref "FMA:5914" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "neurofibrum" . [] oboInOwl:hasDbXref "BAMS:nfi" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "nerve fibers" . [] oboInOwl:hasDbXref "Wikipedia:Nerve_fiber" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006134 ; owl:annotatedTarget "neurofibra" . [] oboInOwl:hasDbXref "ncithesaurus:Myelinated_Nerve_Fiber" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006135 ; owl:annotatedTarget "Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH)." . [] oboInOwl:source "ncithesaurus:Myelinated_Nerve_Fiber" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006135 ; owl:annotatedTarget "UMLS:C0027750" . [] oboInOwl:source "ncithesaurus:Unmyelinated_Nerve_Fiber" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006136 ; owl:annotatedTarget "UMLS:C0501409" . _:genid141564 oboInOwl:hasDbXref "FMA:5916" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006136 ; owl:annotatedTarget "non-myelinated nerve fiber" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 . [] oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0099864", "GO:0061285", "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006170 ; owl:annotatedTarget "The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006183 ; owl:annotatedTarget _:genid143031 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006183 ; owl:annotatedTarget _:genid143033 . [] oboInOwl:hasDbXref "GO:0061249" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006183 ; owl:annotatedTarget "." . _:genid141577 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001516, obo:UBERON_0001757 . [] oboInOwl:source "http://php.med.unsw.edu.au" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget _:genid143037 . [] oboInOwl:hasDbXref "FMA:61006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget "concha" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001008 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:source "ncithesaurus:Concha" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget "UMLS:C0229316" . [] oboInOwl:hasDbXref "FMA:61006", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget "concha auriculae" . [] oboInOwl:hasDbXref "FMA:61006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget "concha of auricle" . [] oboInOwl:hasDbXref "FMA:61006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006203 ; owl:annotatedTarget "concha of pinna" . [] oboInOwl:hasDbXref "Wikipedia:Inguinal_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006204 ; owl:annotatedTarget "A band running from the pubic tubercle to the anterior superior iliac spine. Its anatomy is very important for operating on hernia patients. It forms the base of the inguinal canal through which an indirect inguinal hernia may develop. The inguinal ligament runs from the anterior superior iliac spine of the ilium to the pubic tubercle of the pubic bone. It is formed by the external abdominal oblique aponeurosis and is continuous with the fascia lata of the thigh." . [] oboInOwl:hasDbXref "FMA:19855", "Wikipedia:Inguinal_ligament" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006204 ; owl:annotatedTarget "Poupart's ligament" . [] oboInOwl:hasDbXref "FMA:19855" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006204 ; owl:annotatedTarget "Vesalius' ligament" . _:genid141588 oboInOwl:hasDbXref "FMA:19855", "Wikipedia:Inguinal_ligament" ; oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006204 ; owl:annotatedTarget "fallopian ligament" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001008 ; owl:annotatedTarget "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." . _:genid141590 oboInOwl:hasDbXref "MP:0004221" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006206 ; owl:annotatedTarget "Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005868 . [] oboInOwl:hasDbXref "FMA:58577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006206 ; owl:annotatedTarget "anterior chamber angle" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget _:genid143058 . [] oboInOwl:source "PMID:6844926", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget _:genid143060 . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-anhydro-D-glucitol" . [] oboInOwl:hasDbXref "MP:0010650", "Wikipedia:Aorticopulmonary_septum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions." . [] oboInOwl:hasDbXref "Wikipedia:Aorticopulmonary_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "aortico-pulmonary septum" . [] oboInOwl:hasDbXref "Wikipedia:Aorticopulmonary_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "aorticopulmonary septum" . [] oboInOwl:hasDbXref "Wikipedia:Aorticopulmonary_septum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "septum aorticopulmonale" . [] oboInOwl:hasDbXref "Wikipedia:Aorticopulmonary_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "aortic septum" . [] oboInOwl:hasDbXref "Wikipedia:Aorticopulmonary_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006207 ; owl:annotatedTarget "spiral septum" . [] oboInOwl:hasDbXref "Wikipedia:Pinna_(anatomy)#Development" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006208 ; owl:annotatedTarget "A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head." . [] oboInOwl:hasDbXref "VHOG:0001364" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006208 ; owl:annotatedTarget "auditory tubercles" . _:genid141616 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget _:genid143074 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 . [] oboInOwl:hasDbXref "MP:0012521" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." . _:genid141618 oboInOwl:hasDbXref "MP:0012521" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget "oral membrane" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007122 . [] oboInOwl:hasDbXref "MP:0012521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget "oral plate" . [] oboInOwl:hasDbXref "Wikipedia:Buccopharyngeal_membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget "oropharyngeal membrane" . [] oboInOwl:hasDbXref "MP:0012521" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006211 ; owl:annotatedTarget "pharyngeal membrane" . _:genid141622 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005863 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001435 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009668 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006213 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a carpal bone." . [] oboInOwl:hasDbXref "EMAPA:18102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006213 ; owl:annotatedTarget "carpal cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006214 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a carpal bone." . [] oboInOwl:hasDbXref "EMAPA:17724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006214 ; owl:annotatedTarget "carpal pre-cartilage condensation" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget _:genid143104 . [] oboInOwl:source "EHDAA2", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget _:genid143106 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0012525" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001440" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "The interface between the dorsal neuroepithelium and the roofplate of the fourth ventricle. The source of a number of migratory neuron populations of the hindbrain.[TAO]" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "cerebellar anlage" . [] oboInOwl:hasDbXref "EMAPA:17074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "cerebellar primordium" . [] oboInOwl:hasDbXref "EHDAA2:0000231", "EMAPA:17074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "cerebellum primordium" . [] oboInOwl:hasDbXref "EMAPA:17074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "dorsal part of alar plate of metencephalon" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "future cerebellum" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "presumptive cerebellum" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006215 ; owl:annotatedTarget "rostral rhombic lip" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget _:genid143118 . [] oboInOwl:hasDbXref "MP:0011837", "MP:anna", "Wikipedia:Cloacal_membrane" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget "The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001198" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget "A membrane that separates the proctodeum and the hindgut in the early embryo. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.497, see_Kardong_KV][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001198" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "PMID:11830557 De Santa Barbara P, Roberts DJ, Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13. Development (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget "In mammals, the cloaca exists as an embryonic structure that undergoes septation to become distinct urethral, anal, and genital orifices.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Cloacal_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget "UMLS:C0231056" . [] oboInOwl:hasDbXref "Wikipedia:Cloacal_membrane" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006217 ; owl:annotatedTarget "membrana cloacalis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006219 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006219 ; owl:annotatedTarget _:genid143130 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006219 ; owl:annotatedTarget _:genid143132 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006222 ; owl:annotatedTarget _:genid143138 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Diencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006222 ; owl:annotatedTarget "The foremost region of the future forebrain that develops into the diencephalon." . [] oboInOwl:hasDbXref "TAO:0000574" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006222 ; owl:annotatedTarget "presumptive diencephalon" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006227 ; owl:annotatedTarget _:genid143148 . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006227 ; owl:annotatedTarget _:genid143150 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006227 ; owl:annotatedTarget _:genid143152 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006230 ; owl:annotatedTarget _:genid143154 . [] oboInOwl:source "EHDAA2", "ISBN:0781772214" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006230 ; owl:annotatedTarget _:genid143156 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006232 ; owl:annotatedTarget _:genid143158 . [] oboInOwl:hasDbXref "EMAPA:16660" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006232 ; owl:annotatedTarget "facio-acoustic preganglion complex" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006233 ; owl:annotatedTarget _:genid143166 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006233 ; owl:annotatedTarget "A differentiated genital tubercle that is part of a female reproductive system." . [] oboInOwl:hasDbXref "EMAPA:18680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006233 ; owl:annotatedTarget "genital tubercle of female" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006234 ; owl:annotatedTarget "A femur endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-ANHYDROSORBITOL" . [] oboInOwl:hasDbXref "EMAPA:17502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006234 ; owl:annotatedTarget "femoral pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006235 ; owl:annotatedTarget "An anatomical junctions that overlaps the foregut and midgut." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000291" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006235 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006236 ; owl:annotatedTarget "frontal bone primordium" . [] oboInOwl:hasDbXref "NLX:94995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "The embryonic precursor of the brain." . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO)" . [] oboInOwl:hasDbXref "TAO:0000146" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "brain rudiment" . [] oboInOwl:hasDbXref "ZFA:0000146" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "presumptive brain" . [] oboInOwl:hasDbXref "NLX:94995" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "encephalon" . [] oboInOwl:hasDbXref "BTO:0004726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006238 ; owl:annotatedTarget "embryonic brain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006240 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a forebrain." . [] oboInOwl:hasDbXref "ZFA:0000062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006240 ; owl:annotatedTarget "presumptive forebrain" . [] oboInOwl:hasDbXref "TAO:0000062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006240 ; owl:annotatedTarget "presumptive prosencephalon" . [] oboInOwl:hasDbXref "EHDAA2:0000661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006240 ; owl:annotatedTarget "prosencephalon" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006241 ; owl:annotatedTarget _:genid143210 . [] oboInOwl:hasDbXref "ZFA:0000417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006241 ; owl:annotatedTarget "presumptive spinal cord" . [] oboInOwl:hasDbXref "TAO:0000417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006241 ; owl:annotatedTarget "presumptive spinal cord neural keel" . [] oboInOwl:hasDbXref "TAO:0000417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006241 ; owl:annotatedTarget "presumptive spinal cord neural plate" . [] oboInOwl:hasDbXref "TAO:0000417" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006241 ; owl:annotatedTarget "presumptive spinal cord neural rod" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006242 ; owl:annotatedTarget _:genid143222 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006242 ; owl:annotatedTarget _:genid143224 . [] oboInOwl:hasDbXref "ISBN:0815318960", "XAO:0004205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006242 ; owl:annotatedTarget "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006245 ; owl:annotatedTarget _:genid143233 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006245 ; owl:annotatedTarget _:genid143235 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006245 ; owl:annotatedTarget _:genid143237 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006245 ; owl:annotatedTarget "A humerus endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EMAPA:17713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006245 ; owl:annotatedTarget "humeral cartilage condensation" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006246 ; owl:annotatedTarget _:genid143246 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006246 ; owl:annotatedTarget _:genid143248 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006246 ; owl:annotatedTarget "A humerus endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "EMAPA:17427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006246 ; owl:annotatedTarget "humeral pre-cartilage condensation" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001021 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006247 ; owl:annotatedTarget _:genid143257 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006247 ; owl:annotatedTarget _:genid143259 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006247 ; owl:annotatedTarget "An iliac endochondral element that is composed primarily of a pre-cartilage condensation." . _:genid141778 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002331, obo:UBERON_0005866 . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001021 ; owl:annotatedTarget "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." . _:genid141780 oboInOwl:source "EHDAA2-generalized" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006248 ; owl:annotatedTarget _:genid143266 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005728 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006248 ; owl:annotatedTarget "An incus endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006254 ; owl:annotatedTarget obo:UBERON_0005863 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006254 ; owl:annotatedTarget _:genid143274 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006254 ; owl:annotatedTarget _:genid143276 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006254 ; owl:annotatedTarget "An ischial endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EMAPA:26930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006254 ; owl:annotatedTarget "ischial cartilage condensation" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006255 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006255 ; owl:annotatedTarget _:genid143285 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006255 ; owl:annotatedTarget "An ischial endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-Anhydro-D-sorbitol" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006260 ; owl:annotatedTarget obo:UBERON_0010188 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006260 ; owl:annotatedTarget _:genid143292 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000449" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/lingual+swellings" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006260 ; owl:annotatedTarget "Primordium of the tongue; the median swelling and the distal and proximal swellings arise from the ventral aspect of the stomodeum. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000449" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2002.00073.x Iwasaki S, Evolution of the structure and function of the vertebrate tongue. J Anat (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006260 ; owl:annotatedTarget "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0000996" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006260 ; owl:annotatedTarget "lingual swelling" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006261 ; owl:annotatedTarget _:genid143302 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006261 ; owl:annotatedTarget "A differentiated genital tubercle that is part of a male reproductive system." . _:genid141813 oboInOwl:hasDbXref "EMAPA:17969" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006261 ; owl:annotatedTarget "genital tubercle of male" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009193 . [] oboInOwl:hasDbXref "EMAPA:17969" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006261 ; owl:annotatedTarget "penis anlage" . _:genid141815 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015018 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010728 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006262 ; owl:annotatedTarget _:genid143311 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006262 ; owl:annotatedTarget "A malleus endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006263 ; owl:annotatedTarget _:genid143315 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006263 ; owl:annotatedTarget _:genid143317 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006264 ; owl:annotatedTarget "An anatomical junctions that overlaps the mouth and foregut." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget _:genid143329 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget _:genid143331 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget _:genid143334 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_groove", "http://www.indiana.edu/~anat550/hnanim/face/face.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget "Groove between maxillary prominence and lateral nasal process." . [] oboInOwl:source "ncithesaurus:Nasolacrimal_Groove" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget "UMLS:C1513875" . [] oboInOwl:hasDbXref "EMAPA:16679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget "naso-lacrimal groove" . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_groove" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006266 ; owl:annotatedTarget "s. lacrimalis maxillae" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006267 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006267 ; owl:annotatedTarget _:genid143344 . [] oboInOwl:hasDbXref "VHOG:0001212" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006267 ; owl:annotatedTarget "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001212" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006267 ; owl:annotatedTarget "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]" . [] oboInOwl:source "ncithesaurus:Notochordal_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006267 ; owl:annotatedTarget "UMLS:C1518429" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006268 ; owl:annotatedTarget _:genid143349 . [] oboInOwl:hasDbXref "http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006268 ; owl:annotatedTarget "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot." . [] oboInOwl:source "ncithesaurus:Notochordal_Process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006268 ; owl:annotatedTarget "UMLS:C1518430" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006271 ; owl:annotatedTarget _:genid143357 . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/orbital%20fissure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006271 ; owl:annotatedTarget "Either of two openings transmitting nerves and blood vessels to or from the orbit." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001022 ; owl:annotatedTarget obo:CL_0000576 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006273 ; owl:annotatedTarget obo:UBERON_0016566 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0011172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006273 ; owl:annotatedTarget "The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001147" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://medical-dictionary.thefreedictionary.com/Otic+pit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006273 ; owl:annotatedTarget "A depression appearing in each otic placode, marking the beginnning of embryonic development of the internal ear. [TFD][VHOG]" . [] oboInOwl:hasDbXref "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006273 ; owl:annotatedTarget "otic cup" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001022 ; owl:annotatedTarget "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." . [] oboInOwl:hasDbXref "EHDAA2:0001404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006274 ; owl:annotatedTarget "parietal bone primordium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006279 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006279 ; owl:annotatedTarget _:genid143380 . [] oboInOwl:hasDbXref "ISBN:0124020607", "VHOG:0001505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006279 ; owl:annotatedTarget "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001505" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006279 ; owl:annotatedTarget "Each of the canal that links the peritoneal cavity and the caudal part of a pleural cavity. [ISBN:0124020607][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006279 ; owl:annotatedTarget "pleuroperitoneal channel" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget _:genid143386 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget _:genid143388 . [] oboInOwl:hasDbXref "ZFA:0001719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." . [] oboInOwl:hasDbXref "ZFA:0001719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "presumptive cardiac ventricle heart tube" . [] oboInOwl:hasDbXref "EHDAA2:0001531" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "primitive ventricle" . [] oboInOwl:hasDbXref "EMAPA:16350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "primitive ventricle of heart" . [] oboInOwl:hasDbXref "FMA:71006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "primordial cardiac ventricle" . [] oboInOwl:hasDbXref "FMA:71006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006283 ; owl:annotatedTarget "primordial ventricle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget _:genid143397 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "Future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000644" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "prosencephalic vesicle" . [] oboInOwl:hasDbXref "VHOG:0000644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "forebrain ventricle" . [] oboInOwl:hasDbXref "VHOG:0000644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "forebrain vesicle" . [] oboInOwl:hasDbXref "VHOG:0000644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006284 ; owl:annotatedTarget "prosencephalic ventricle" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-Anhydroglucitol" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006285 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006285 ; owl:annotatedTarget _:genid143410 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006285 ; owl:annotatedTarget "A pubic endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006286 ; owl:annotatedTarget _:genid143417 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006286 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a radius bone." . _:genid141917 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866, obo:UBERON_0010334 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006287 ; owl:annotatedTarget "A radius-ulna endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006287 ; owl:annotatedTarget "EMAPA has a separate radius-ulna cartilage condensation." . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006288 ; owl:annotatedTarget obo:UBERON_0005863 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006288 ; owl:annotatedTarget _:genid143434 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006288 ; owl:annotatedTarget "A rib endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006289 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2-abduced", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006289 ; owl:annotatedTarget _:genid143443 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006289 ; owl:annotatedTarget "A rib endochondral element that is composed primarily of a pre-cartilage condensation." . _:genid141944 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006290 ; owl:annotatedTarget _:genid143452 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010334 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006290 ; owl:annotatedTarget _:genid143454 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006290 ; owl:annotatedTarget "A scapula endochondral element that is composed primarily of cartilage tissue." . _:genid141952 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006291 ; owl:annotatedTarget _:genid143462 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010336 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006291 ; owl:annotatedTarget _:genid143464 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006291 ; owl:annotatedTarget "A scapula endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "PMID:21455939" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0006291 ; owl:annotatedTarget "the scapula has been shown to develop from multiple tissues, such as the dermomyotome of the somites, the mesodermal portion of the soma- topleure (a domain of the lateral plate mesoderm or LPM) and neural crest cell-derived mesenchyme (Huang et al., 2000; Matsuoka et al., 2005; Wang et al., 2005)." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006292 ; owl:annotatedTarget obo:UBERON_0005856 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006292 ; owl:annotatedTarget _:genid143471 . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006292 ; owl:annotatedTarget "this is part of the forelimb skeleton in EHDAA2, but this violates part-disjointness" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget _:genid143476 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget _:genid143478 . [] oboInOwl:hasDbXref "ISBN:0123747295", "MP:0011263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "check difference between splenic and spleen in EMAPA; note that in EHDAA2 the class 'spleen' refers to the mesenchyme" . [] oboInOwl:hasDbXref "MP:0011263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "spleen mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "splenic mesenchyme" . [] oboInOwl:hasDbXref "EHDAA2:0001904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "splenic primordium" . [] oboInOwl:hasDbXref "XAO:0000326" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006293 ; owl:annotatedTarget "left spleen primordium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006294 ; owl:annotatedTarget _:genid143490 . [] oboInOwl:notes "cranial end" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00441.x", "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006294 ; owl:annotatedTarget _:genid143492 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006294 ; owl:annotatedTarget "A stapes endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "DOI:10.1111/j.1469-7580.2005.00441.x" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006294 ; owl:annotatedTarget "stapedial anlage" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006295 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006295 ; owl:annotatedTarget _:genid143498 . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006297 ; owl:annotatedTarget "A primordium that has the potential to develop into a sublingual gland." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006298 ; owl:annotatedTarget "A primordium that has the potential to develop into a submandibular gland." . [] oboInOwl:hasDbXref "EMAPA:17755" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006298 ; owl:annotatedTarget "submaxillary gland primordium" . _:genid141997 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001675, obo:UBERON_0003064 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006304 ; owl:annotatedTarget _:genid143517 . _:genid141999 oboInOwl:hasDbXref "EMAPA:16663" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006304 ; owl:annotatedTarget "trigeminal V preganglion" ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0007297 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-anhydro-D-sorbitol" . [] oboInOwl:hasDbXref "EMAPA:16663" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006304 ; owl:annotatedTarget "trigeminal preganglion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006306 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a ulna." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001023 ; owl:annotatedTarget obo:CL_0001059 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "A segment of the eyeball that is filled with refractive media." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "EMAPA:37529" . [] oboInOwl:source "ncithesaurus:Chamber_of_the_Eye" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "UMLS:C0459556" . [] oboInOwl:hasDbXref "MA:0002459" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "eye chamber" . [] oboInOwl:hasDbXref "FMA:58071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "eyeball chamber" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:1261582", "PMID:17952047", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001023 ; owl:annotatedTarget "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." . [] oboInOwl:hasDbXref "BTO:0002085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006311 ; owl:annotatedTarget "chamber of eye" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006312 ; owl:annotatedTarget "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light." . [] oboInOwl:hasDbXref "MESH:A12.207", "Wikipedia:Body_fluid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006314 ; owl:annotatedTarget "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006314 ; owl:annotatedTarget "EMAPA:37441" . [] oboInOwl:hasDbXref "GAID:266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006314 ; owl:annotatedTarget "body fluid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget obo:UBERON_0006532 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget _:genid143551 . [] oboInOwl:notes "orbital surface of the maxilla lateral to the lacrimal groove" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget _:genid143553 . [] oboInOwl:notes "laterally onto the eyeball deep to the lateral rectus by a short flat tendon" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget _:genid143555 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "Thin, narrow muscle placed near the anterior margin of the floor of the orbit." . _:genid142035 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001132" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008780 . [] oboInOwl:source "ncithesaurus:Inferior_Oblique_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "UMLS:C0582817" . [] oboInOwl:hasDbXref "FMA:49040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "inferior oblique" . [] oboInOwl:hasDbXref "AAO:0010117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "musculus obliquus inferior" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "musculus obliquus inferior bulbi" . [] oboInOwl:hasDbXref "FMA:49040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "obliquus inferior" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "obliquus oculi inferior" . [] oboInOwl:hasDbXref "VHOG:0001132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "ventral oblique extraocular muscle" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_oblique_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "musculus obliquus inferior bulbi" . [] oboInOwl:hasDbXref "VHOG:0001132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006320 ; owl:annotatedTarget "ventral oblique extraocular muscles" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget obo:UBERON_0006532 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget _:genid143569 . [] oboInOwl:notes "Outer posterior quadrant of the eyeball" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget _:genid143572 . [] oboInOwl:hasDbXref "Wikipedia:Superior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "The superior oblique muscle, or obliquus oculi superior, is a fusiform muscle in the upper, medial side of the orbit whose primary action is downward, lateral rotation of the eye. One of the extraocular muscles, the superior oblique is the only muscle innervated by the trochlear nerve (the fourth cranial nerve)." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010119" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "Cranial nerve IV innervated; dorsal in the obliquus group.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001131" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Superior_Oblique_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "UMLS:C0582816" . [] oboInOwl:hasDbXref "VHOG:0001131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "dorsal oblique extraocular muscle" . [] oboInOwl:hasDbXref "AAO:0010119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "musculus obliquus superior" . [] oboInOwl:hasDbXref "FMA:49039" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "obliquus superior" . _:genid142056 oboInOwl:hasDbXref "FMA:49039" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "superior oblique" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 . [] oboInOwl:hasDbXref "Wikipedia:Superior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "M. obliquus superior" . [] oboInOwl:hasDbXref "VHOG:0001131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "dorsal oblique extraocular muscles" . [] oboInOwl:hasDbXref "Wikipedia:Superior_oblique_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "musculus obliquus superior bulbi" . [] oboInOwl:hasDbXref "Wikipedia:Superior_oblique_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006321 ; owl:annotatedTarget "obliquus oculi superior" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget obo:UBERON_0006533 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_rectus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "A muscle in the orbit that depresses, adducts, and helps extort (rotate laterally) the eye. The inferior rectus muscle is the only muscle that is capable of depressing the pupil when it is in a fully abducted position." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001130" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Inferior_Rectus_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "UMLS:C0582819" . [] oboInOwl:hasDbXref "FMA:49036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "inferior rectus" . [] oboInOwl:hasDbXref "AAO:0010101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "musculus rectus inferior" . [] oboInOwl:hasDbXref "VHOG:0001130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "ventral rectus extraocular muscle" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_rectus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "musculus rectus inferior bulbi" . [] oboInOwl:hasDbXref "TAO:0000457" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "ventral recti" . [] oboInOwl:hasDbXref "TAO:0000457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006322 ; owl:annotatedTarget "ventral rectus" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006325 ; owl:annotatedTarget "EMAPA:37628" . [] oboInOwl:hasDbXref "FMA:72058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006325 ; owl:annotatedTarget "intrinsic ligament of larynx" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006328 ; owl:annotatedTarget "EMAPA:37630" . [] oboInOwl:hasDbXref "FEED:FEED" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006328 ; owl:annotatedTarget "intrinsic laryngeal muscle" . [] oboInOwl:hasDbXref "FMA:55226" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006328 ; owl:annotatedTarget "intrinsic muscle of larynx" . [] oboInOwl:hasDbXref "FEED:FEED" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006328 ; owl:annotatedTarget "intrinsic laryneal muscles" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006331 ; owl:annotatedTarget "A nucleus of brain that is part of a brainstem." . [] oboInOwl:hasDbXref "EMAPA:32790" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006331 ; owl:annotatedTarget "brain stem nucleus" . [] oboInOwl:hasDbXref "Wikipedia:Snout" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006333 ; owl:annotatedTarget "." . [] oboInOwl:date_retrieved "2012-10-05" ; oboInOwl:ontology "ZFA" ; oboInOwl:ontology_class "ZFA:0005496" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006333 ; owl:annotatedTarget "Surface structure that is the region of the head in front of and between the orbits, and above the lower jaw. Nares are located on the snout[ZFA]." . [] oboInOwl:hasDbXref "MA:0001910" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006333 ; owl:annotatedTarget "muzzle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006338 ; owl:annotatedTarget "A choroid plexus stroma that is part of a lateral ventricle." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006339 ; owl:annotatedTarget "A choroid plexus stroma that is part of a third ventricle." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006339 ; owl:annotatedTarget "EMAPA:37056" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16070 ; owl:annotatedTarget "1,5-anhydroglucitol" . (obo:UBERON_0005206 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006340 ; owl:annotatedTarget "A choroid plexus stroma that is part of a fourth ventricle." . [] oboInOwl:hasDbXref "ncithesaurus:Communicating_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006347 ; owl:annotatedTarget "An artery that connects two larger arteries." . [] oboInOwl:source "ncithesaurus:Communicating_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006347 ; owl:annotatedTarget "UMLS:C1707451" . ( ) . [] oboInOwl:hasDbXref "ncithesaurus:Epigastric_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006349 ; owl:annotatedTarget "An external iliac artery branch that supplies blood to the anterior abdominal wall." . [] oboInOwl:source "ncithesaurus:Epigastric_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006349 ; owl:annotatedTarget "UMLS:C0282640" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006355 ; owl:annotatedTarget obo:UBERON_0002460 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006356 ; owl:annotatedTarget "A vein that drains the anterior abdominal wall." . [] oboInOwl:source "ncithesaurus:Epigastric_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006356 ; owl:annotatedTarget "UMLS:C1707930" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006430 ; owl:annotatedTarget "A costal cartilage that is part of a xiphoid process." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000940" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006430 ; owl:annotatedTarget "Distal, cartilaginous portion of the sternum.[AAO]" . [] oboInOwl:hasDbXref "FMA:32574" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006430 ; owl:annotatedTarget "cartilage of xiphoid process" . [] oboInOwl:hasDbXref "FMA:32574" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006430 ; owl:annotatedTarget "xiphoid process cartilage" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006430 ; owl:annotatedTarget "ensiform cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006431 ; owl:annotatedTarget "A bone tissue that is part of a xiphoid process." . [] oboInOwl:hasDbXref "FMA:32577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006431 ; owl:annotatedTarget "bone tissue of xiphoid process" . [] oboInOwl:hasDbXref "Wikipedia:Xiphoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006431 ; owl:annotatedTarget "xiphoid bone" . [] oboInOwl:hasDbXref "MGI:anna", "MP:0009103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006435 ; owl:annotatedTarget "The unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species." . [] oboInOwl:hasDbXref "Wikipedia:Baculum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006435 ; owl:annotatedTarget "baculum" . [] oboInOwl:hasDbXref "MP:0009104", "Wikipedia:Baculum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006435 ; owl:annotatedTarget "penile bone" . _:genid142152 oboInOwl:hasDbXref "Wikipedia:Baculum" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006435 ; owl:annotatedTarget "penis bone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004188 . [] oboInOwl:hasDbXref "MP:0011849" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006440 ; owl:annotatedTarget "The ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans; it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals." . [] oboInOwl:hasDbXref "Wikipedia:Baculum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006440 ; owl:annotatedTarget "baubellum" . [] oboInOwl:hasDbXref "MP:0011849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006440 ; owl:annotatedTarget "clitoral bone" . [] oboInOwl:hasDbXref "Wikipedia:Baculum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006440 ; owl:annotatedTarget "os clitoridis" . [] oboInOwl:hasDbXref "BTO:0003627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006444 ; owl:annotatedTarget "A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart)." . [] oboInOwl:hasDbXref "BTO:0003627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006444 ; owl:annotatedTarget "anulus" . [] oboInOwl:hasDbXref "FMA:76704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006444 ; owl:annotatedTarget "anulus fibrosus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006444 ; owl:annotatedTarget "fibrocartilaginous ring" . [] oboInOwl:hasDbXref "BTO:0003627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006444 ; owl:annotatedTarget "fibrous ring" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget obo:UBERON_0014378 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "Any of the interosseous muscles of the pes (foot). Includes the plantar and dorsal interossei." . [] oboInOwl:source "MURDOCH:920" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "Interroseous muscles are short digital muscles found together on the plantar aspect of the hindlimb. They act as shock absorbers for the pes, and closely resemble the interossei found in the forelimb. They originate from the proximal ends of all metatarsal bones and initially insert on the sesamoid bones at the metatarsophalangeal joints. The interosseous are then continued by distal sesamoidean ligaments which join the extensor tendons and attach to the phalanges[MURDOCH:920]." . [] oboInOwl:source "ncithesaurus:Foot_Interosseous_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "UMLS:C0448494" . [] oboInOwl:hasDbXref "FMA:37456" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "foot interosseous" . [] oboInOwl:hasDbXref "MA:0002302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "foot interosseus muscle" . [] oboInOwl:hasDbXref "FMA:37456" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "interosseous of foot" . [] oboInOwl:hasDbXref "FMA:37456" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006497 ; owl:annotatedTarget "interosseous muscle of foot" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006508 ; owl:annotatedTarget _:genid143710 . [] oboInOwl:hasDbXref "Wikipedia:Interossei", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006508 ; owl:annotatedTarget "Any of the muscles of the autopod region that lie between metacarpal or metatarsal bones." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006508 ; owl:annotatedTarget "interossei" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget obo:UBERON_0002020 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget _:genid143715 . [] oboInOwl:hasDbXref "http://www.medterms.com/script/main/art.asp?articlekey=11614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget "Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum." . [] oboInOwl:source "ABA" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget obo:UBERON_0002435 . [] oboInOwl:hasDbXref "FMA:83684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget "neuraxis pallidum" . [] oboInOwl:hasDbXref "FMA:83684" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006514 ; owl:annotatedTarget "pallidum of neuraxis" . [] oboInOwl:hasDbXref "MESH:A05.810.453.537.503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211)." . [] oboInOwl:hasDbXref "EMAPA:18676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "calyx" . [] oboInOwl:source "ncithesaurus:Renal_Calyx" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "UMLS:C0022651" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "calices renales" . [] oboInOwl:hasDbXref "MA:0000369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "renal calyx" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006517 ; owl:annotatedTarget "calices renales" . [] oboInOwl:hasDbXref "BTO:0000136" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006524 ; owl:annotatedTarget "System pertaining to a bronchus and alveoli." . [] oboInOwl:hasDbXref "MP:0010899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006524 ; owl:annotatedTarget "pulmonary alveolar system" . [] oboInOwl:hasDbXref "BTO:0000136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006524 ; owl:annotatedTarget "bronchoalveolar system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006530 ; owl:annotatedTarget "A substance formed from the secretion of one or more glands of the male genital tract in which sperm cells are suspended." . [] oboInOwl:source "DOI:10.1046/j.1365-2540.2001.00961.x" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0006530 ; owl:annotatedTarget "This term covers a variety of species. Example: In D. melanogaster, seminal fluid proteins affect female receptivity, ovulation, oogenesis, sperm storage, sperm competition and mating plug formation" . [] oboInOwl:hasDbXref "BTO:0001232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006530 ; owl:annotatedTarget "seminal plasma" . [] oboInOwl:hasDbXref "PMID:31287811", "PMID:35203131" ; obo2:IAO_0000232 "A secretion from the glands of the male reproductive system in some aquatic animals that contains sperm and is sprayed onto the eggs." ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006530 ; owl:annotatedTarget "milt" . [] oboInOwl:hasDbXref "BTO:0001232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006530 ; owl:annotatedTarget "seminal fluid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006531 ; owl:annotatedTarget obo:UBERON_0001601 . [] oboInOwl:hasDbXref "MESH:A02.633.567.700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006531 ; owl:annotatedTarget "The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006531 ; owl:annotatedTarget "we follow MA in making this a subclass of extra-ocular muscle but the distinction is not clear" . [] oboInOwl:source "ncithesaurus:Oculomotor_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006531 ; owl:annotatedTarget "UMLS:C0028863" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006535 ; owl:annotatedTarget "A portion of organism substance that secreted_by a zone of skin." . [] oboInOwl:hasDbXref "MA:0002537" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006535 ; owl:annotatedTarget "skin fluid/secretion" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006536 ; owl:annotatedTarget "A portion of organism substance that is secreted by a male reproductive gland." . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." . [] oboInOwl:hasDbXref "MA:0002521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006536 ; owl:annotatedTarget "male reproductive system fluid/secretion" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006537 ; owl:annotatedTarget "A portion of organism substance that is secreted by a female reproductive gland." . [] oboInOwl:hasDbXref "MA:0002510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006537 ; owl:annotatedTarget "female reproductive system fluid/secretion" . [] oboInOwl:hasDbXref "PMID:16140871" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001024 ; owl:annotatedTarget "CD133-positive hematopoietic stem cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006538 ; owl:annotatedTarget "A portion of organism substance that secreted_by a respiratory system." . [] oboInOwl:source "ncithesaurus:Respiratory_System_Fluid_or_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006538 ; owl:annotatedTarget "UMLS:C1514899" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006539 ; owl:annotatedTarget "A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006544 ; owl:annotatedTarget "A vasculature that is part of a kidney." . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-071029-9" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006553 ; owl:annotatedTarget "A tube in the kidney that collect and transport urine." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006553 ; owl:annotatedTarget "in ZFA this is defined as part of mesonephros" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006555 ; owl:annotatedTarget "A tube that is part of a excretory system." . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget _:genid143801 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget _:genid143803 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010522" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "in FMA this is part of the cardiovascular system, but here we treat the CV system as a separate component of the circulatory system from the lymphatic system" . [] oboInOwl:hasDbXref "FMA:7162", "MA:0002435" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "lymphatic system" . [] oboInOwl:hasDbXref "FMA:7162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "lymphatic tree system" . [] oboInOwl:hasDbXref "VHOG:0001761" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006558 ; owl:annotatedTarget "lymporeticular system" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006561 ; owl:annotatedTarget "An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels.." . [] oboInOwl:hasDbXref "FMA:74623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006561 ; owl:annotatedTarget "non-lymphatic lymphoid system" . [] oboInOwl:hasDbXref "GO:0060465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006562 ; owl:annotatedTarget "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." . _:genid142288 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:CL_0000335, obo:UBERON_0002333 . [] oboInOwl:hasDbXref "FMA:85030", "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006563 ; owl:annotatedTarget "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]." . _:genid142293 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003100, obo:UBERON_0004288 . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:External_urethral_orifice_(female)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "A urethral meatus that is part of a female urethra[Automatically generated definition]." . [] oboInOwl:source "Wikipedia:External_urethral_orifice_(female)" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "The external urethral orifice (urinary meatus) is the external opening of the urethra, from which urine is ejected during urination. It is placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina; it usually assumes the form of a short, sagittal cleft with slightly raised margins. To its left and right are the openings of the Skene's ducts." . [] oboInOwl:hasDbXref "FMA:85266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "external orifice of female urethra" . [] oboInOwl:hasDbXref "FMA:85266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "external urethral orifice (female)" . [] oboInOwl:hasDbXref "FMA:85266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "female urethral meatus" . [] oboInOwl:hasDbXref "FMA:85266", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "ostium urethrae externum (urethra feminina)" . [] oboInOwl:hasDbXref "EMAPA:36453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "urethral meatus of clitoral urethra" . [] oboInOwl:hasDbXref "EMAPA:36453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "distal urethral opening of female" . [] oboInOwl:hasDbXref "EMAPA:36453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006565 ; owl:annotatedTarget "urethral opening of clitoral urethra" . _:genid142305 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001083 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 ] ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000680 . _:genid142310 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006566 ; owl:annotatedTarget "A myocardium that is part of a left ventricle of a heart." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004288 . [] oboInOwl:source "FMA:9558" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006566 ; owl:annotatedTarget "Myocardium of ventricle which is continuous with the tunica media of aorta." . [] oboInOwl:hasDbXref "FMA:9558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006566 ; owl:annotatedTarget "left ventricular myocardium" . [] oboInOwl:hasDbXref "FMA:9558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006566 ; owl:annotatedTarget "myocardium of left ventricle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006567 ; owl:annotatedTarget "A myocardium that is part of a right ventricle of a heart." . [] oboInOwl:source "FMA:9535" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006567 ; owl:annotatedTarget "Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk." . [] oboInOwl:hasDbXref "FMA:9535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006567 ; owl:annotatedTarget "myocardium of right ventricle" . [] oboInOwl:hasDbXref "FMA:9535" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006567 ; owl:annotatedTarget "right ventricular myocardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006568 ; owl:annotatedTarget "A nucleus of brain that is part of a hypothalamus." . [] oboInOwl:hasDbXref "FMA:258762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006568 ; owl:annotatedTarget "nucleus of hypothalamus" . _:genid142329 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006569 ; owl:annotatedTarget "A nucleus of brain that is part of a diencephalon." . _:genid142334 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0007651 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000931 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001046 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003050 . [] oboInOwl:hasDbXref "Wikipedia:Pectinate_line" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "FMA also has FMA:29321 but it's not clear how this differs" . [] oboInOwl:source "ncithesaurus:Pectinate_Line" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "UMLS:C0821671" . [] oboInOwl:hasDbXref "FMA:75383", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "linea pectinata canalis analis" . [] oboInOwl:hasDbXref "FMA:75383" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "pectinate line of anal canal" . [] oboInOwl:hasDbXref "EMAPA:19159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "Hilton's 'white line'" . [] oboInOwl:hasDbXref "Wikipedia:Pectinate_line" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "dentate line" . [] oboInOwl:hasDbXref "Wikipedia:Pectinate_line" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "linea anocutanea" . [] oboInOwl:hasDbXref "Wikipedia:Pectinate_line" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "recto-anal junction" . [] oboInOwl:hasDbXref "EMAPA:19159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006574 ; owl:annotatedTarget "site of anal membrane" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006585 ; owl:annotatedTarget _:genid143884 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006585 ; owl:annotatedTarget "An organ that is part of a vestibular system." . [] oboInOwl:source "BIRNLEX:2519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006585 ; owl:annotatedTarget "UMLS:C0682674" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006585 ; owl:annotatedTarget "balance organ" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget obo:UBERON_0008845 . [] oboInOwl:notes "lower gubernaculum" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget _:genid143890 . [] oboInOwl:hasDbXref "MESH:A02.513.803", "Wikipedia:Round_ligament_of_uterus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "The round ligament of the uterus originates at the uterine horns, in the parametrium. It leaves the pelvis via the deep inguinal ring, passes through the inguinal canal and continues on to the labia majora where its fibers spread and mix with the tissue of the mons pubis[WP]. A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus[MESH]." . [] oboInOwl:hasDbXref "GAID:130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "round ligament" . [] oboInOwl:source "ncithesaurus:Round_Ligament_of_the_Uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "UMLS:C0035877" . [] oboInOwl:hasDbXref "FMA:20420" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "Hunter's ligament" . [] oboInOwl:hasDbXref "Wikipedia:Round_ligament_of_uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "ligamentum teres uteri" . [] oboInOwl:hasDbXref "Wikipedia:Round_ligament_of_uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "round ligament of the uterus" . [] oboInOwl:hasDbXref "Wikipedia:Round_ligament_of_uterus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006589 ; owl:annotatedTarget "ligamentum teres uteri" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006595 ; owl:annotatedTarget "Presumptive structure of the blastula that will develop into endoderm." . ( ) . [] oboInOwl:hasDbXref "GOC:CVS", "GOC:YMB", "ZFA:0001116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006598 ; owl:annotatedTarget "Portion of embryonic tissue determined by fate mapping to become a structure." . [] oboInOwl:hasDbXref "ZFA:0001116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006598 ; owl:annotatedTarget "presumptive structures" . [] oboInOwl:source "NCBIBook:NBK10065" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006600 ; owl:annotatedTarget _:genid143922 . _:genid142396 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000076, obo:UBERON_0000924 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006601 ; owl:annotatedTarget "Presumptive structure of the blastula that will develop into ectoderm." . [] oboInOwl:hasDbXref "ZFA:0001376" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006601 ; owl:annotatedTarget "presumptive epidermis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006603 ; owl:annotatedTarget "Presumptive structure of the blastula that will develop into mesoderm." . _:genid142412 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget obo:UBERON_0002216 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:notes "connects adjacent mandibles" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget _:genid143945 . _:genid142414 oboInOwl:hasDbXref "TAO:wd", "Wikipedia:Symphysis_menti", "ZFA:0005488" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003066 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001851" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "Joint that articulates the left and right dentary bones. Mandibular symphysis is unpaired.[TAO]" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "in snakes, the mandibular symphysis is composed of soft tissues, allowing independent movement of each mandible" . [] oboInOwl:hasDbXref "TAO:0001851" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "dentary symphysis" . [] oboInOwl:hasDbXref "TAO:0001851" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "inter-dentary joint" . [] oboInOwl:hasDbXref "TAO:0001851" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "inter-mandibular joint" . [] oboInOwl:hasDbXref "MA:0001490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "symphysis menti" . [] oboInOwl:hasDbXref "Wikipedia:Symphysis_menti" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "mental symphysis" . [] oboInOwl:hasDbXref "Wikipedia:Symphysis_menti" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006606 ; owl:annotatedTarget "symphysis mandibulae" . _:genid142425 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002411, obo:UBERON_0004871 . _:genid142427 oboInOwl:hasDbXref "Wikipedia:Corpus_cavernosum_of_clitoris" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "The corpus cavernosum clitoridis is one of a pair of sponge-like regions of erectile tissue which contain most of the blood in the clitoris during clitoral erection. This is homologous to the corpus cavernosum penis in the male; the body of the clitoris contains erectile tissue in a pair of corpora cavernosa (literally 'cave-like bodies'), with a recognisably similar structure." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0004872 . [] oboInOwl:hasDbXref "FMA:20172" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "corpus cavernosum of clitoris" . [] oboInOwl:hasDbXref "BTO:0002018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "cavernous body of clitoris" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001025 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "BTO:0002018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "clitoral corpus cavernosum" . [] oboInOwl:hasDbXref "BTO:0002018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "corpus cavernosum" . [] oboInOwl:hasDbXref "Wikipedia:Corpus_cavernosum_of_clitoris" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006608 ; owl:annotatedTarget "corpus cavernosum clitoridis" . [] oboInOwl:hasDbXref "Wikipedia:Corpus_cavernosum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006609 ; owl:annotatedTarget "." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget obo:UBERON_0000158 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget _:genid143968 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget _:genid143970 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget _:genid143972 . [] oboInOwl:hasDbXref "AEO:0000092", "Wikipedia:Aponeurosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "A sheet of extracellular matrix." . [] oboInOwl:source "Wikipedia:Aponeurosis" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "Aponeuroses are layers of flat broad tendons. They have a shiny, whitish-silvery color, and are histologically similar to tendons, but are very sparingly supplied with blood vessels and nerves. When dissected, aponeuroses are papery, and peel off by sections. The primary regions with thick aponeurosis is in the ventral abdominal region, the dorsal lumbar region, and in the palmar region. Their primary function is to join muscles and the body parts the muscles act upon[Wikipedia:Aponeurosis]." . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001025 ; owl:annotatedTarget "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "in ZFA, aponeuroses are subtypes of tendons, but this is inconsistent with tendons being muscle-bone connections" . [] oboInOwl:source "ncithesaurus:Aponeurosis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "UMLS:C0225205" . [] oboInOwl:hasDbXref "Wikipedia:Aponeurosis" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "aponeuroses" . [] oboInOwl:hasDbXref "Wikipedia:Aponeurosis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006614 ; owl:annotatedTarget "aponeurotic" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/venous+sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006615 ; owl:annotatedTarget "A large vein or channel for the circulation of venous blood." . [] oboInOwl:source "ncithesaurus:Venous_Sinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006615 ; owl:annotatedTarget "UMLS:C0226504" . [] oboInOwl:hasDbXref "ZFA:0007072" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006615 ; owl:annotatedTarget "blood sinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006616 ; owl:annotatedTarget "An external ear that is in the right side of a multicellular organism." . [] oboInOwl:hasDbXref "FMA:53643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006616 ; owl:annotatedTarget "right auricular region" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006616 ; owl:annotatedTarget "EMAPA:37361" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006617 ; owl:annotatedTarget "An external ear that is in the left side of a multicellular organism." . [] oboInOwl:hasDbXref "FMA:53644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006617 ; owl:annotatedTarget "left auricular region" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006617 ; owl:annotatedTarget "EMAPA:37360" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/musculophrenic+artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006632 ; owl:annotatedTarget "An artery with its origin in the lateral terminal branch of the internal thoracic artery, with distribution to the diaphragm and the intercostal muscles, and with anastomoses to the branches of the pericardiacophrenic and inferior phrenic." . [] oboInOwl:hasDbXref "FMA:10645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006632 ; owl:annotatedTarget "musculophrenic artery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:source "EMAPA", "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget _:genid144006 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "http://www.merriam-webster.com/medical/coracoid%20process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget "A process of the scapula in most mammals representing the remnant of the coracoid bone of lower vertebrates thas has become fused with the scapula." . [] oboInOwl:source "Wikipedia:Coracoid_process" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget "The coracoid process is a small hook-like structure on the lateral edge of the superior anterior portion of the scapula. Pointing laterally forward, it, together with the acromion, serves to stabilize the shoulder joint. It is palpable in the deltopectoral groove between the deltoid and pectoralis major muscles. It is the site of attachment for several structures: * The pectoralis minor muscle - to 3rd to 5th ribs. * The short head of biceps brachii muscle - to Radial tuberosity. * The coracobrachialis muscle - to medial humerus. * The coracoclavicular ligament - to the clavicle. (The ligament is formed by the conoid ligament and trapezoid ligament.) * The coracoacromial ligament - to the acromion[WP][Wikipedia:Coracoid_process]." . [] oboInOwl:hasDbXref "Wikipedia:Coracoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget "coracoid process" . [] oboInOwl:hasDbXref "Wikipedia:Coracoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget "coracoid process of the scapula" . [] oboInOwl:hasDbXref "Wikipedia:Coracoid_process" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006633 ; owl:annotatedTarget "processus coracoideus" . [] oboInOwl:hasDbXref "Wikipedia:Abdominal_wall" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006635 ; owl:annotatedTarget "The abdominal wall represents the boundaries of the abdominal cavity. The abdominal wall is split into the posterior (back), lateral (sides) and anterior (front) walls. There is a common set of layers covering and forming all the walls: the deepest being the extraperitoneal fat, the parietal peritoneum, and a layer of fascia which has different names over where it covers (eg transversalis, psoas fascia). Superficial to these, but not present in the posterior wall are the three layers of muscle, the transversus abdominis (transverse abdominal muscle), the internal (obliquus internus) and the external oblique (obliquus externus)." . _:genid142482 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "A muscle layer that is part of a fallopian tube." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscle layer of fallopian tube" . _:genid142484 oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscle layer of oviduct" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscle layer of uterine tube" . _:genid142486 oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscular coat of uterine tube" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001801 . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscular layer of uterine tube" . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "muscularis of uterine tube" . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "tunica muscularis (Tuba uterina)" . [] oboInOwl:hasDbXref "FMA:18318", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "tunica muscularis tubae uterinae" . [] oboInOwl:hasDbXref "FMA:18318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006642 ; owl:annotatedTarget "uterine tubal muscularis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006645 ; owl:annotatedTarget "An adventitia that is part of a epididymis." . [] oboInOwl:hasDbXref "FMA:19136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006645 ; owl:annotatedTarget "epididymis adventitia" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "Beilstein:1721708" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006646 ; owl:annotatedTarget "A muscle layer that is part of a epididymis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "An adventitia that is part of a vas deferens." . [] oboInOwl:hasDbXref "FMA:19238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "adventitia of deferent duct" . [] oboInOwl:hasDbXref "FMA:19238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "adventitia of ductus deferens" . [] oboInOwl:hasDbXref "FMA:19238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "adventitia of vas deferens" . [] oboInOwl:hasDbXref "FMA:19238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "deferent ductal adventitia" . [] oboInOwl:hasDbXref "FMA:19238" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "tunica adventitia (ductus deferens)" . [] oboInOwl:hasDbXref "FMA:19238", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006647 ; owl:annotatedTarget "tunica adventitia ductus deferentis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006648 ; owl:annotatedTarget "An adventitia that is part of a seminal vesicle." . [] oboInOwl:hasDbXref "FMA:19403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006648 ; owl:annotatedTarget "adventitia of seminal gland" . [] oboInOwl:hasDbXref "FMA:19403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006648 ; owl:annotatedTarget "seminal vesicle adventitia" . [] oboInOwl:hasDbXref "FMA:19403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006648 ; owl:annotatedTarget "tunica adventitia (vesicula seminalis)" . [] oboInOwl:hasDbXref "FMA:19403", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006648 ; owl:annotatedTarget "tunica adventitia glandulae vesiculosae" . [] oboInOwl:hasDbXref "FMA:19976" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006652 ; owl:annotatedTarget "muscular coat of vagina" . [] oboInOwl:hasDbXref "FMA:19976", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006652 ; owl:annotatedTarget "tunica muscularis vaginae" . _:genid142529 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0035651 _:genid142531 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001703 . _:genid142531 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411, obo:UBERON_0003112 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget _:genid144070 . [] oboInOwl:hasDbXref "BTO:0003117", "Wikipedia:Clitoral_glans" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "Erectile tissue at the end of the clitoris, which is continuous with the intermediate part of the vestibulovaginal bulbs[BTO]. The clitoral glans (glans clitoridis) is an external portion of the clitoris[WP]." . [] oboInOwl:source "ncithesaurus:Glans_Clitoris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "UMLS:C0227769" . [] oboInOwl:hasDbXref "FMA:19999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "clitoris glans" . [] oboInOwl:hasDbXref "FMA:19999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "glans of clitoris" . [] oboInOwl:hasDbXref "Wikipedia:Clitoral_glans" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "glans clitoridis" . [] oboInOwl:hasDbXref "Wikipedia:Clitoral_glans" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006653 ; owl:annotatedTarget "glans clitoris" . _:genid142548 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009889, obo:UBERON_0013718 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=81109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006655 ; owl:annotatedTarget "An incomplete wall of connective tissue and nonstriated muscle (dartos fascia) dividing the scrotum into two sacs, each containing a testis." . [] oboInOwl:hasDbXref "FMA:20729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006655 ; owl:annotatedTarget "scrotal septum" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006655 ; owl:annotatedTarget "septum scroti" . [] oboInOwl:notes "to be revised after scapulocoracoid fixes" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget _:genid144091 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "Anatomical cavity for the proximal articular surface of the proximal limb or fin element with the scapulocoracoid or equivalent structure." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000749" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "Cavity for the articulation of the forelimb formed by the scapula, coracoid, and clavicle.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000749" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "relationship loss: part_of scapular area (AAO:0000935)[AAO]" . [] oboInOwl:source "ad" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "The glenoid fossa can be associated with the metapterygium in sarcopterygians, or either the meso- or propterygium in basal gnathostomes such as Chondrichthyans" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "FMA also has classes for the bony parts around the cavity - these may be more useful than the cavity term itself" . [] oboInOwl:source "ncithesaurus:Glenoid_Fossa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "UMLS:C1261046" . [] oboInOwl:hasDbXref "FMA:23275", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "cavitas glenoidalis scapulae" . [] oboInOwl:hasDbXref "FMA:23275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "cavitus glenoidalis" . [] oboInOwl:hasDbXref "FMA:23275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "glenoid cavity" . [] oboInOwl:hasDbXref "FMA:23275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "glenoid cavity of scapula" . [] oboInOwl:hasDbXref "Wikipedia:Glenoid_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "cavitas glenoidalis" . [] oboInOwl:hasDbXref "AAO:0000749" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006657 ; owl:annotatedTarget "glenoid cavity" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget _:genid144109 . [] oboInOwl:notes "two phalanges in series" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget _:genid144111 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget "A joint that connects one phalanx to another along a proximodistal axis." . [] oboInOwl:source "ncithesaurus:Interphalangeal_Joint" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget "Hinge joints between the phalanges of the hand or foot[ncithesaurus:Interphalangeal_Joint]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget "EMAPA:37884" . [] oboInOwl:hasDbXref "FMA:42765" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006658 ; owl:annotatedTarget "inter-phalangeal joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget obo:UBERON_0004923 . [] oboInOwl:hasDbXref "Wikipedia:Muscular_layer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." . [] oboInOwl:source "BTO:0004838" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "An outer layer of smooth muscle surrounding a hollow or tubular organ as the bladder, esophagus, large intestine, small intestine, stomach, ureter, uterus, and vagina that often consists of an inner layer of circular fibers serving to narrow the lumen of the organ and an outer layer of longitudinal fibers serving to shorten its length[BTO]." . [] oboInOwl:source "ncithesaurus:Muscle_Layer" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "UMLS:C0225358" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "muscular layer" . [] oboInOwl:hasDbXref "FMA:45634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "muscularis layer" . [] oboInOwl:hasDbXref "BTO:0004838" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "tunica muscularis" . [] oboInOwl:hasDbXref "Wikipedia:Muscularis_externa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "muscular coat" . [] oboInOwl:hasDbXref "BTO:0004838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "muscularis externa" . [] oboInOwl:hasDbXref "Wikipedia:Muscularis_externa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "muscularis propria" . [] oboInOwl:hasDbXref "Wikipedia:Muscularis_externa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "transverse muscular fibers" . [] oboInOwl:hasDbXref "BTO:0004838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "tunica externa" . [] oboInOwl:hasDbXref "Wikipedia:Muscularis_externa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006660 ; owl:annotatedTarget "tunica muscularis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget _:genid144132 . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance." . [] oboInOwl:hasDbXref "FMA:46768", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "aponeurosis epicranialis" . [] oboInOwl:hasDbXref "FMA:46768" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "aponeurosis of epicranius" . [] oboInOwl:hasDbXref "FMA:46768" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "epicranial aponeurosis" . [] oboInOwl:hasDbXref "FMA:46768" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "epicranius aponeurosis" . [] oboInOwl:hasDbXref "FMA:46768" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "galea aponeurotica" . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "cranial aponeurosis" . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "epicranial aponeurosis" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "Beilstein:1752568" . [] oboInOwl:hasDbXref "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001026 ; owl:annotatedTarget "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "galea aponeurosis" . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "galea aponeurotica; aponeurosis epicranialis" . [] oboInOwl:hasDbXref "Wikipedia:Galea_aponeurotica" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006661 ; owl:annotatedTarget "galeal aponeurosis" . [] oboInOwl:hasDbXref "Wikipedia:Greater_palatine_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006664 ; owl:annotatedTarget "The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity." . [] oboInOwl:hasDbXref "MA:0001993" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006664 ; owl:annotatedTarget "major palatine artery" . [] oboInOwl:hasDbXref "Wikipedia:Greater_palatine_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006664 ; owl:annotatedTarget "arteria palatina major" . [] oboInOwl:hasDbXref "Wikipedia:Carotid_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006668 ; owl:annotatedTarget "On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Carotid_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006668 ; owl:annotatedTarget "canalis caroticus" . [] oboInOwl:source "inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget _:genid144160 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget "A fat pad that is part of a orbital region." . [] oboInOwl:hasDbXref "FMA:59005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget "intraorbital fat pad" . [] oboInOwl:hasDbXref "FMA:59005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget "orbital fat" . [] oboInOwl:hasDbXref "FMA:59005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget "orbital fat body" . [] oboInOwl:hasDbXref "FMA:59005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006671 ; owl:annotatedTarget "retrobulbar fat" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Mandibular_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006673 ; owl:annotatedTarget "A canal within the mandible that contains the inferior alveolar nerve, inferior alveolar artery, and inferior alveolar vein. It runs obliquely downward and forward in the ramus, and then horizontally forward in the body, where it is placed under the alveoli and communicates with them by small openings." . [] oboInOwl:external_ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006673 ; owl:annotatedTarget "TAO has mandibular sensory canal, which is part of the lateral line system" . [] oboInOwl:hasDbXref "EMAPA:19161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006673 ; owl:annotatedTarget "inferior alveolar canal" . [] oboInOwl:hasDbXref "Wikipedia:Inguinal_rings" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006674 ; owl:annotatedTarget "An entrance or exit of the inguinal canal." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006675 ; owl:annotatedTarget "A valve that is part of a vein." . [] oboInOwl:hasDbXref "FMA:68095" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006675 ; owl:annotatedTarget "valve of vein" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006677 ; owl:annotatedTarget "An anatomical boundary that adjacent_to a epithelium." . [] oboInOwl:hasDbXref "FMA:70997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006677 ; owl:annotatedTarget "epithelium surface" . _:genid142654 oboInOwl:hasDbXref "Wikipedia:Hypoglossal_canal" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006682 ; owl:annotatedTarget "The hypoglossal canal is a bony canal in the occipital bone of the skull." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004124 . [] oboInOwl:hasDbXref "EMAPA:19012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006682 ; owl:annotatedTarget "anterior condylar canal" . [] oboInOwl:hasDbXref "Wikipedia:Hypoglossal_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006682 ; owl:annotatedTarget "canalis nervi hypoglossi" . [] oboInOwl:hasDbXref "Wikipedia:Hypoglossal_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006682 ; owl:annotatedTarget "hyperglossal canal" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_fontanelle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006683 ; owl:annotatedTarget "A gap between bones in the skull at the junction of the sagittal suture and lambdoidal suture." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006683 ; owl:annotatedTarget "fonticulus posterior" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006683 ; owl:annotatedTarget "posterior fontanelle of skull" . _:genid142667 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006686 ; owl:annotatedTarget "A vein that is part of a vertebral column." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002062 . [] oboInOwl:hasDbXref "FMA:76735", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006686 ; owl:annotatedTarget "vena spinalis" . [] oboInOwl:hasDbXref "FMA:76735" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006686 ; owl:annotatedTarget "spinal branch" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "A small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue." . [] oboInOwl:source "ncithesaurus:Frenulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "UMLS:C2339893" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_tongue" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "frenulum linguae" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "frenulum linguæ" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "frenulum of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "lingual frenulum" . [] oboInOwl:hasDbXref "FMA:54659" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "tongue frenulum" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006689 ; owl:annotatedTarget "lingual frenum" . [] oboInOwl:hasDbXref "Wikipedia:Spinal_canal", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000693" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "Canal formed by the vertebral centra ventrally, the pedicels laterally, and the neural arches dorsally that encloses and protects the spinal cord.[AAO]" . [] oboInOwl:source "ncithesaurus:Vertebral_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "UMLS:C0037922" . [] oboInOwl:source "ncithesaurus:Neural_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "UMLS:C1522467" . [] oboInOwl:hasDbXref "Wikipedia:Spinal_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "c. vertebralis" . [] oboInOwl:hasDbXref "AAO:0000693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "foramen vertebrale" . [] oboInOwl:hasDbXref "AAO:0000693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "neural canal" . [] oboInOwl:hasDbXref "AAO:0000693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "spinal canal" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "CAS:352-21-6" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001027 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "Wikipedia:Spinal_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "spinal cavity" . [] oboInOwl:hasDbXref "Wikipedia:Spinal_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006692 ; owl:annotatedTarget "vertebral canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006694 ; owl:annotatedTarget "A vasculature that is part of a cerebellum." . [] oboInOwl:hasDbXref "GOC:amm", "GO_REF:0000031", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001027 ; owl:annotatedTarget "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006715 ; owl:annotatedTarget _:genid144254 . [] oboInOwl:hasDbXref "AAO:Maglia_et_al_2007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006715 ; owl:annotatedTarget "Paired, long bones of endochondral origin formed by the fusion of the radius and ulna." . _:genid142716 oboInOwl:hasDbXref "XAO:0003209" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006715 ; owl:annotatedTarget "radioulna" ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0005484 . [] oboInOwl:hasDbXref "XAO:0003209" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006715 ; owl:annotatedTarget "radius-ulna" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006716 ; owl:annotatedTarget _:genid144268 . [] oboInOwl:hasDbXref "MA:th", "Wikipedia:Carpus_and_tarsus_of_land_vertebrates", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006716 ; owl:annotatedTarget "The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus)." . [] oboInOwl:hasDbXref "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006716 ; owl:annotatedTarget "mesopodial limb segment" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "The collection of all skeletal elements in an autopodium region." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005019" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "Distal section of the limb skeleton, consisting of the anterior autopodium or posterior autopodium.[VSAO]" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "autopod skeleton" . [] oboInOwl:hasDbXref "VSAO:0005019" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "autopodial skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "skeletal parts of autopod" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "skeleton of autopod" . [] oboInOwl:hasDbXref "VSAO:0005019", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006717 ; owl:annotatedTarget "autopodium" . [] oboInOwl:notes "mandibular nerve via nerve to medial pterygoid" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget _:genid144287 . [] oboInOwl:source "MFMO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget _:genid144289 . [] oboInOwl:notes "medial surface in MFMO" ; oboInOwl:source "MFMO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget _:genid144291 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget obo:UBERON_0006719 . [] oboInOwl:hasDbXref "MFMO:0000083" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle.[FEED]" . [] oboInOwl:source "ncithesaurus:Internal_Pterygoid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "UMLS:C1512882" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "musculus pterygoideus internus" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "musculus pterygoideus medialis" . [] oboInOwl:hasDbXref "MA:0002361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "pterygoid medialis" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "pterygoideus medial" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "pterygoideus medialis" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "internal pterygoid" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "medial pterygoid" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "pterygoidei internus" . [] oboInOwl:hasDbXref "Wikipedia:Medial_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006718 ; owl:annotatedTarget "pterygoideus internus" . [] oboInOwl:is_indirect "true" ; oboInOwl:notes "lateral pterygoid nerve from the mandibular nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget _:genid144312 . [] oboInOwl:notes "Great wing of sphenoid and pterygoid plate" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget _:genid144315 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget _:genid144317 . [] oboInOwl:hasDbXref "MFMO:0000074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and temporomandibular joint (TMJ) capsule, and the cranial base." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and TMJ capsule, and the cranial base.[FEED]" . [] oboInOwl:hasDbXref "FEED:rd", "MA:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "pterygoid lateralis" . [] oboInOwl:source "ncithesaurus:External_Pterygoid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "UMLS:C1517045" . _:genid142772 oboInOwl:hasDbXref "MFMO:0000074" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "external pterygoid muscle" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0005805 . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "lateral pteregoid" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "lateral pteregoid muscle" . [] oboInOwl:hasDbXref "FEED:rd", "FMA:49015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "lateral pterygoid" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "m. pterygoideus externus" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "m. pterygoideus lateralis" . [] oboInOwl:hasDbXref "FEED:rd", "FMA:49015" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "musculus pterygoides lateralis" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "musculus pterygoideus externus" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "musculus pterygoideus lateralis" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "pterygoideus externus" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "pterygoideus externus muscle" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "pterygoideus lateral" . [] oboInOwl:hasDbXref "FEED:rd", "Wikipedia:Lateral_pterygoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006719 ; owl:annotatedTarget "pterygoideus lateral muscle" . [] oboInOwl:notes "generalized from lateral and medial" ; oboInOwl:source "FEED", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006720 ; owl:annotatedTarget _:genid144336 . [] oboInOwl:notes "generalized" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006720 ; owl:annotatedTarget _:genid144338 . [] oboInOwl:hasDbXref "EMAPA:25139" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006720 ; owl:annotatedTarget "pterygoid" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget _:genid144342 . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?manubrium+of+malleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "The handle of the malleus; the portion that extends downward, inward, and backward from the neck of the malleus; it is embedded throughout its length in the tympanic membrane." . [] oboInOwl:source "http://audilab.bmed.mcgill.ca/AudiLab/teach/me_saf/me_saf.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "Conical in shape, with the cone extending inwards (e.g. mammals) or outwards (e.g. in birds)" . [] oboInOwl:hasDbXref "FMA:52760" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "malleus handle" . [] oboInOwl:hasDbXref "FMA:52760" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "manubrium of malleus" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "handle of malleus" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "malleal manubrium" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "malleus handle" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "malleus manubrium" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "manubrium mallei" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "CAS:352-21-6" . [] oboInOwl:hasDbXref "MA:0002985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006722 ; owl:annotatedTarget "manubrium of malleus" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget _:genid144355 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MGI:anna", "MP:0003309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "The central cone shaped core of spongy bone about which turns the spiral canal." . [] oboInOwl:hasDbXref "MA:0001182" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "modiolus" . [] oboInOwl:source "ncithesaurus:Modiolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "UMLS:C0229503" . _:genid142806 oboInOwl:hasDbXref "FMA:61278" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "cochlea modiolus" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002270 . [] oboInOwl:hasDbXref "FMA:61278", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "modiolus cochleae" . [] oboInOwl:hasDbXref "FMA:61278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "modiolus of cochlea" . [] oboInOwl:hasDbXref "BTO:0001693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006723 ; owl:annotatedTarget "columella cochleae" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001028 ; owl:annotatedTarget obo:CL_0000051 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "A corner of the outer (lateral) part of an eye." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001571" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "The angle at the end of the palpebral fissure, the slit between the eyelids, close to the temporal region of the skull. [ISBN:0124020607, p.263][VHOG]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "EMAPA:37458" . [] oboInOwl:source "ncithesaurus:Outer_Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "UMLS:C1711189" . [] oboInOwl:hasDbXref "FMA:59321" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "lateral canthus of eye" . [] oboInOwl:hasDbXref "FMA:59315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "lateral palpebral commissure" . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001028 ; owl:annotatedTarget "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." . [] oboInOwl:hasDbXref "FMA:59321" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "lateral angle of eye" . [] oboInOwl:hasDbXref "MA:0001264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "lateral canthus" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006726 ; owl:annotatedTarget "outer canthi" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "A canthus is a corner of the eye where the upper and lower eyelids meet. The bicanthal plane is the transversal plane linking both canthi and defines the upper boundary of the midface." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "EMAPA:37457" . [] oboInOwl:hasDbXref "FMA:59222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "palpebral commissure" . [] oboInOwl:hasDbXref "FMA:59222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "angle of eye" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "bicanthal" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "bicanthal plane" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "canthi" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "canthoplasty" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "canthorum" . [] oboInOwl:hasDbXref "Wikipedia:Canthus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "canthus (anatomy)" . [] oboInOwl:hasDbXref "FMA:59222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006742 ; owl:annotatedTarget "canthus of eye" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget _:genid144394 . [] oboInOwl:hasDbXref "Wikipedia:Tuberculum_impar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget "During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000730" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2002.00073.x", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" . [] oboInOwl:hasDbXref "EHDAA2:0001081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget "median lingual swelling" . [] oboInOwl:hasDbXref "http://emedicine.medscape.com/article/845125-overview" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget "median tongue bud" . [] oboInOwl:hasDbXref "Wikipedia:Tuberculum_impar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006756 ; owl:annotatedTarget "tuberculum linguale mediale" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_lingual_swelling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006757 ; owl:annotatedTarget "During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000731" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2002.00073.x Iwasaki S, Evolution of the structure and function of the vertebrate tongue. J Anat (2002)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006757 ; owl:annotatedTarget "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_lingual_swelling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006757 ; owl:annotatedTarget "lateral swellings" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_lingual_swelling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006757 ; owl:annotatedTarget "tuberculum laterale" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_lingual_swelling" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006757 ; owl:annotatedTarget "tuberculum linguale laterale" . ( ) . [] oboInOwl:hasDbXref "MP:0013477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "EMAPA:37835" . [] oboInOwl:hasDbXref "FMA:58342", "GAID:896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "corneal limbus" . [] oboInOwl:hasDbXref "PMID:17051547" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "corneal-scleral limbus" . [] oboInOwl:hasDbXref "GAID:896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "corneoscleral junction" . [] oboInOwl:hasDbXref "Wikipedia:Corneal_limbus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "limbus corneae" . [] oboInOwl:hasDbXref "FMA:58342" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "sclerocorneal junction" . [] oboInOwl:hasDbXref "GAID:896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "sclerocorneal limbus" . [] oboInOwl:hasDbXref "Wikipedia:Corneal_limbus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006761 ; owl:annotatedTarget "limbus corneae" . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget obo:UBERON_0008841 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget _:genid144427 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget _:genid144431 . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "The zonule of Zinn (Zinn's membrane, ciliary zonule) is a ring of fibrous strands connecting the ciliary body with the crystalline lens of the eye. The zonule of Zinn is split into two layers: a thin layer, which lines the hyaloid fossa, and a thicker layer, which is a collection of zonular fibers. Together, the fibers are known as the suspensory ligament of the lens[WP]. Modified or toughened vitreous that suspend the lens at the equator to the non-pigmented epithelium of the ciliary zone. In zebrafish, dorsal zonules are thickened as compared to ventral zonules. In both dorsal and ventral regions, these fibers delimit the vitreous body aqueous humor boundary[ZFA]." . [] oboInOwl:hasDbXref "FMA:58838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "Zinn's membrane" . [] oboInOwl:hasDbXref "FMA:58838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "ciliary zonule" . [] oboInOwl:hasDbXref "FMA:58838" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonule of Zinn" . [] oboInOwl:hasDbXref "ZFA:0005573" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonules" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "ciliary zonule" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "suspensory ligament of the lens" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonula" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonula ciliaris" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonular fiber" . [] oboInOwl:hasDbXref "Wikipedia:Zonule_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006762 ; owl:annotatedTarget "zonule" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget obo:UBERON_0010304 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget _:genid144449 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget "Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue." . [] oboInOwl:source "ncithesaurus:Conjunctival_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget "UMLS:C1179037" . [] oboInOwl:hasDbXref "FMA:62131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget "conjunctiva epithelium" . [] oboInOwl:hasDbXref "BTO:0005131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006763 ; owl:annotatedTarget "conjunctival epithelium" . [] oboInOwl:hasDbXref "MESH:A02.835.232.500.247.343", "Wikipedia:Femur_head" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "The hemispheric articular surface at the upper extremity of the thigh bone[Stedman, 26th ed]. The femur head is the highest part of the thigh bone. It is supported by the neck of the femur. The head is globular and forms rather more than a hemisphere, is directed upward, medialward, and a little forward, the greater part of its convexity being above and in front. Its surface is smooth, coated with cartilage in the fresh state, except over an ovoid depression, the fovea capitis femoris, which is situated a little below and behind the center of the head, and gives attachment to the ligament of head of femur. If there is a fracture of the neck of the femur, the blood supply through the ligament becomes crucial. In orthopedic surgery, the head of the femur is important because it can undergo avascular necrosis and consequent osteochondritis dissecans. The head is removed in total hip replacement surgery [WP]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000892" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "Proximal head of the femur, which articulates with the acetabulum.[AAO]" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "Drug_Central:1263" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "EMAPA:37541" . [] oboInOwl:source "ncithesaurus:Head_of_the_Femur" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "UMLS:C0015813" . [] oboInOwl:hasDbXref "AAO:0000892" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "acetabular head" . [] oboInOwl:hasDbXref "FMA:32851" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "femoral head" . [] oboInOwl:hasDbXref "FMA:32851", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "kopf des Schenkelbeins" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/capital+femoral+epiphysis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "capital femoral epiphysis" . [] oboInOwl:hasDbXref "AAO:0000892", "Wikipedia:Femur_head" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "caput femoris" . [] oboInOwl:hasDbXref "MESH:A02.835.232.500.247.343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006767 ; owl:annotatedTarget "femur head" . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006799 ; owl:annotatedTarget "An epithelium that is composed primarily of secretory cells." . [] oboInOwl:source "ncithesaurus:Glandular_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006799 ; owl:annotatedTarget "UMLS:C0682578" . [] oboInOwl:source "ncithesaurus:Glandular_Epithelial_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006799 ; owl:annotatedTarget "UMLS:C1708242" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006800 ; owl:annotatedTarget "Non-material anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface." . [] oboInOwl:hasDbXref "Wikipedia:Upper_extremity_of_humerus#Humeral_head" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "Hemispherical structure on proximal epiphysis of humerus that articulates with glenoid cavity[WP,modified]." . [] oboInOwl:external_class "AAO:0000835" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "Hemispherical ball on the proximal end of the humerus that fits into the glenoid cavity of the pectoral girdle to form the shoulder joint[AAO]." . [] oboInOwl:source "ncithesaurus:Head_of_the_Humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "UMLS:C0223683" . [] oboInOwl:hasDbXref "FMA:13304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "head of humerus" . [] oboInOwl:hasDbXref "AAO:0000835", "Wikipedia:Upper_extremity_of_humerus#Humeral_head" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "caput humeri" . [] oboInOwl:hasDbXref "FMA:13304", "PHENOSCAPE:curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006801 ; owl:annotatedTarget "humeral head" . _:genid142926 oboInOwl:hasDbXref "AAO:0000812" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "Medial end of the clavicle, which usually lies on the ventral side of the epicoracoid cartilage, just posterior to the epicoracoid bridge." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008231 . [] oboInOwl:hasDbXref "FMA:23297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "extremitas sternalis (clavicula)" . [] oboInOwl:hasDbXref "FMA:23297", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "extremitas sternalis claviculae" . [] oboInOwl:hasDbXref "FMA:23297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "medial end of clavicle" . [] oboInOwl:hasDbXref "AAO:0000812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "extremitas medialis" . [] oboInOwl:hasDbXref "AAO:0000812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "medial end" . [] oboInOwl:hasDbXref "FMA:23297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006805 ; owl:annotatedTarget "proximal epyphysis of clavicle" . [] oboInOwl:hasDbXref "Wikipedia:Olecranon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "The olecranon is a large, thick, curved bony eminence of the forearm that projects behind the elbow. It is situated at the upper (proximal) end of the ulna, one of the two bones in the forearm. When the hand faces forward the olecranon faces towards the back (posteriorly). It is bent forward at the summit so as to present a prominent lip which is received into the olecranon fossa of the humerus in extension of the forearm. Its base is contracted where it joins the body and the narrowest part of the upper end of the ulna. Its posterior surface, directed backward, is triangular, smooth, subcutaneous, and covered by a bursa. Its superior surface is of quadrilateral form, marked behind by a rough impression for the insertion of the Triceps brachii; and in front, near the margin, by a slight transverse groove for the attachment of part of the posterior ligament of the elbow-joint. Its anterior surface is smooth, concave, and forms the upper part of the semilunar notch. Its borders present continuations of the groove on the margin of the superior surface; they serve for the attachment of ligaments, viz. , the back part of the ulnar collateral ligament medially, and the posterior ligament laterally. From the medial border a part of the Flexor carpi ulnaris arises; while to the lateral border the anconeus muscle is attached." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000843" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "Large and thick process situated at the proximal (upper) end of the ulna. Its inner face forms the medial articular surface that articulates with the humeral head.[AAO]" . [] oboInOwl:source "ncithesaurus:Olecranon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "UMLS:C0223710" . [] oboInOwl:hasDbXref "Wikipedia:Olecranon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "olecranon process of ulna" . [] oboInOwl:hasDbXref "Wikipedia:Olecranon" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "olecranon process" . [] oboInOwl:hasDbXref "AAO:0000843" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006810 ; owl:annotatedTarget "ulnar process" . [] oboInOwl:hasDbXref "Wikipedia:Mental_foramen" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006812 ; owl:annotatedTarget "The mental foramen is one of two holes ('foramina') located on the anterior surface of the mandible. It permits passage of the mental nerve and vessels. The mental foramen descends slightly in edentulous individuals." . [] oboInOwl:hasDbXref "OBOL:automatic" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006812 ; owl:annotatedTarget "mental foramina" . [] oboInOwl:hasDbXref "Wikipedia:Mental_foramen" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006812 ; owl:annotatedTarget "foramen mentale" . [] oboInOwl:hasDbXref "Wikipedia:Mental_foramen" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006812 ; owl:annotatedTarget "foramen mentalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006813 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006813 ; owl:annotatedTarget _:genid144514 . [] oboInOwl:notes "facial series" ; oboInOwl:source "Kardong-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006813 ; owl:annotatedTarget _:genid144516 . [] oboInOwl:hasDbXref "AAO:0000320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006813 ; owl:annotatedTarget "Structural framework that provides support to the nasal sacs and ducts." . [] oboInOwl:hasDbXref "FMA:60116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006813 ; owl:annotatedTarget "skeleton of nose" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget obo:UBERON_0011825 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget _:genid144523 . [] oboInOwl:hasDbXref "FMA:63897" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000027" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000027" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "cushions body organs" . [] oboInOwl:hasDbXref "FMA:63897" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "loose areolar connective tissue" . [] oboInOwl:hasDbXref "AAO:0000027" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006815 ; owl:annotatedTarget "loose connective tissue" . [] oboInOwl:hasDbXref "Wikipedia:Head_of_ulna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "The head of ulna presents an articular surface, part of which, of an oval or semilunar form, is directed downward, and articulates with the upper surface of the triangular articular disk which separates it from the wrist-joint; the remaining portion, directed lateralward, is narrow, convex, and received into the ulnar notch of the radius." . [] oboInOwl:hasDbXref "FMA:33751", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "caput ulnae" . [] oboInOwl:hasDbXref "FMA:33751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "head of ulna" . _:genid142977 oboInOwl:hasDbXref "FMA:33751" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "proximal end of ulna" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 . [] oboInOwl:hasDbXref "FMA:33751" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "upper end of ulna" . [] oboInOwl:hasDbXref "Wikipedia:Head_of_ulna" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006822 ; owl:annotatedTarget "caput ulnae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006833 ; owl:annotatedTarget "An anatomical space that surrounded_by a trachea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006833 ; owl:annotatedTarget "lumen of cartilaginous trachea" . [] oboInOwl:hasDbXref "FMA:7469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006833 ; owl:annotatedTarget "tracheal lumen" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006834 ; owl:annotatedTarget "A subdivision of a the reproductive tract in a female organism that is the site of embryo development." . [] oboInOwl:hasDbXref "FBbt:00004924" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006834 ; owl:annotatedTarget "uterus" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "4-amino-3-hydroxybutanoic acid" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget obo:UBERON_0006839 . [] oboInOwl:hasDbXref "Wikipedia:Spinal_nerve", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "Branch of spinal nerve that innervates the hypaxial muscles." . [] oboInOwl:hasDbXref "FMA:5982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "ramus anterior" . [] oboInOwl:hasDbXref "FMA:5982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "anterior primary ramus of spinal nerve" . [] oboInOwl:hasDbXref "FMA:5982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "anterior ramus of spinal nerve" . [] oboInOwl:hasDbXref "FMA:5982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "ventral ramus of spinal nerve" . [] oboInOwl:hasDbXref "FMA:5982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "anterior branch of spinal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ramus_of_spinal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006838 ; owl:annotatedTarget "ramus anterior nervi spinalis" . [] oboInOwl:hasDbXref "Wikipedia:Spinal_nerve", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "Branch of spinal nerve that innervates the epaxial muscles." . [] oboInOwl:hasDbXref "FMA:5983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "dorsal ramus" . [] oboInOwl:hasDbXref "FMA:5983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "ramus posterior" . [] oboInOwl:hasDbXref "FMA:5983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "posterior primary ramus" . [] oboInOwl:hasDbXref "FMA:5983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "posterior ramus of spinal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_ramus_of_spinal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "ramus posterior nervi spinalis" . [] oboInOwl:hasDbXref "FMA:5983" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006839 ; owl:annotatedTarget "posterior branch of spinal nerve" . [] oboInOwl:hasDbXref "ZFA:0005168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006841 ; owl:annotatedTarget "Vein that is central to a lobule in the liver." . [] oboInOwl:hasDbXref "ZFA:0005168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006841 ; owl:annotatedTarget "central vein" . [] oboInOwl:hasDbXref "FMA:17544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006841 ; owl:annotatedTarget "terminal branch of hepatic vein" . [] oboInOwl:hasDbXref "FMA:17544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006841 ; owl:annotatedTarget "terminal hepatic venule" . [] oboInOwl:hasDbXref "FMA:17544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006841 ; owl:annotatedTarget "vena centralis (hepar)" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget obo:UBERON_0000476 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget _:genid144591 . [] oboInOwl:hasDbXref "ncithesaurus:Tooth_Cusp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "A raised area of the biting surface of a tooth." . _:genid143031 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001973" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "Anatomical structure that is a natural outgrowth, prominence, or point that is part of the surface of a tooth.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005322 . [] oboInOwl:date_retrieved "2012-09-28" ; oboInOwl:source "http://anthro.palomar.edu/primate/glossary.htm" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "the elevated, somewhat pointed portions of the chewing surfaces on premolar and molar teeth" . _:genid143033 oboInOwl:source "ncithesaurus:Tooth_Cusp" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "UMLS:C0226994" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005325 . [] oboInOwl:hasDbXref "FMA:56481" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "tooth cusp" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006844 ; owl:annotatedTarget "tooth cone" . _:genid143037 oboInOwl:hasDbXref "AEO:0000161", "AEO:JB", "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006846 ; owl:annotatedTarget "A furrow or an incomplete tube." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0016612 . [] oboInOwl:hasDbXref "AEO:0000161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006846 ; owl:annotatedTarget "groove" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006847 ; owl:annotatedTarget "A nervous system commissure that connects a left hemisphere of cerebellum and connects a right hemisphere of cerebellum." . [] oboInOwl:hasDbXref "ZFA:0000490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006847 ; owl:annotatedTarget "commissura cerebelli" . [] oboInOwl:source "ZFA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget _:genid144615 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget _:genid144617 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget _:genid144619 . [] oboInOwl:hasDbXref "VSAO:0000157", "https://github.com/obophenotype/uberon/issues/204", "https://github.com/obophenotype/uberon/issues/339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage." . [] oboInOwl:source "TAO:0000583" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "Endochondral bone that is located medial to the cleithrum, and articulates ventrally with the coracoid, medially with the mesocoracoid when the later is present and posteriorly with the upper one to three proximal radials. The scapula develops from the scapulocoracoid cartilage and belongs to the primary pectoral girdle. It may be perforated by the scapular foramen or it may be notched ventr and forms together with a similar notch of the coracoid the scapulocoracoid foramen[TAO:0000583]." . _:genid143058 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000751" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "Paired bony elements of endochondral origin. They are situated at the level of the jaw articulation, in a vertical position, with the suprascapular margin being dorsal and the glenoid end being ventral.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004145 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000751" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "relationship loss: has pars glenoidalis of scapula (AAO:0000753)[AAO]" . _:genid143060 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000751" ; oboInOwl:ontology "AAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "relationship loss: part_of scapular area (AAO:0000935)[AAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000095 . [] oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "present in all tetrapods with even vestiges of anterior limbs, e.g., turtles & birds & mammals." . [] oboInOwl:source "ncithesaurus:Scapula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "UMLS:C0036277" . [] oboInOwl:hasDbXref "ZFA:0000583" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "scapulae" . [] oboInOwl:hasDbXref "BTO:0001218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "scapula bone" . [] oboInOwl:hasDbXref "TAO:0000583" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006849 ; owl:annotatedTarget "scapulas" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget _:genid144636 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "A muscular coat that is part of a ureter." . [] oboInOwl:hasDbXref "FMA:15893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "muscular coat of ureter" . [] oboInOwl:hasDbXref "FMA:15893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "muscular layer of ureter" . _:genid143074 oboInOwl:hasDbXref "FMA:15893" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "muscularis of ureter" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006264 . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "tunica muscularis (ureter)" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "tunica muscularis ureteris" . [] oboInOwl:hasDbXref "EMAPA:28567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006855 ; owl:annotatedTarget "ureteral smooth muscle layer" . [] oboInOwl:hasDbXref "GO:0030325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006858 ; owl:annotatedTarget "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001141" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006858 ; owl:annotatedTarget "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0001141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006858 ; owl:annotatedTarget "adrenal gland - interrenal gland" . [] oboInOwl:hasDbXref "VHOG:0001141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006858 ; owl:annotatedTarget "adrenal - interrenal gland" . [] oboInOwl:hasDbXref "VHOG:0001141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006858 ; owl:annotatedTarget "suprarenal gland - interrenal gland" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006861 ; owl:annotatedTarget "Subdivision of long bone which forms the part of the bone between two metaphyses. Note that the diaphysis includes the metaphyses, but the diaphysis proper excludes these." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006861 ; owl:annotatedTarget "The MA class is associated with EMAPA:35505 but we associate this with the more precise concept of diaphyseal plate" . [] oboInOwl:hasDbXref "FMA:32688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006861 ; owl:annotatedTarget "body proper of long bone" . [] oboInOwl:hasDbXref "FMA:32688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006861 ; owl:annotatedTarget "shaft proper of long bone" . [] oboInOwl:hasDbXref "MA:0002803" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006861 ; owl:annotatedTarget "long bone diaphysis" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Body_of_femur" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "A diaphysis that is part of a femur[Automatically generated definition]." . [] oboInOwl:source "Wikipedia:Body_of_femur" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "The body of the femur (or shaft), almost cylindrical in form, is a little broader above than in the center, broadest and somewhat flattened from before backward below. It is slightly arched, so as to be convex in front, and concave behind, where it is strengthened by a prominent longitudinal ridge, the linea aspera. It presents for examination three borders, separating three surfaces. Of the borders, one, the linea aspera, is posterior, one is medial, and the other, lateral[Wikipedia:Body_of_femur]." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "gamma-Amino-beta-hydroxybutyric acid" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "EMAPA:37538" . [] oboInOwl:hasDbXref "FMA:32847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "body of femur" . [] oboInOwl:hasDbXref "FMA:32847", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "corpus femoris" . [] oboInOwl:hasDbXref "FMA:32847" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "femoral diaphysis" . _:genid143104 oboInOwl:hasDbXref "FMA:32847" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006862 ; owl:annotatedTarget "shaft of femur" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028 . (obo:UBERON_0004378 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006863 ; owl:annotatedTarget _:genid144676 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006863 ; owl:annotatedTarget "A proximal metaphysis that is part of a femur." . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006864 ; owl:annotatedTarget _:genid144683 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006864 ; owl:annotatedTarget "A distal metaphysis that is part of a femur." . (obo:UBERON_0001438 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000981 ] ) . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006865 ; owl:annotatedTarget _:genid144690 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006865 ; owl:annotatedTarget "A metaphysis that is part of a femur." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006865 ; owl:annotatedTarget "EMAPA:37540" . [] oboInOwl:hasDbXref "FMA:32875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006865 ; owl:annotatedTarget "femoral metaphysis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006866 ; owl:annotatedTarget "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." . [] oboInOwl:hasDbXref "FBbt:00005756" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006866 ; owl:annotatedTarget "rectum" . _:genid143130 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002356, obo:UBERON_0008713 . _:genid143132 oboInOwl:hasDbXref "Wikipedia:Anal_triangle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006867 ; owl:annotatedTarget "The anal triangle is the posterior part of the perineum. It contains the anal canal. [WP,unvetted]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . [] oboInOwl:hasDbXref "FMA:20347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006867 ; owl:annotatedTarget "anal region" . [] oboInOwl:hasDbXref "FMA:20347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006867 ; owl:annotatedTarget "anal triangle" . [] oboInOwl:hasDbXref "Wikipedia:Anal_triangle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006867 ; owl:annotatedTarget "regio analis" . _:genid143138 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0003000 ; owl:someValuesFrom obo:UBERON_0006240, obo:UBERON_0006530 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006868 ; owl:annotatedTarget "A gland that secretes a seminal fluid." . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0004576", "UBERON:cjm", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2218" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006871 ; owl:annotatedTarget "The distal elements of the developing limb of vertebrates that will give rise to the pes (foot)." . _:genid143148 oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006871 ; owl:annotatedTarget "EHDAA2 does not have a single class for footplate, but includes epithelium, mesenchyme and AER" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 . [] oboInOwl:source "ncithesaurus:Foot_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006871 ; owl:annotatedTarget "UMLS:C1517291" . _:genid143150 oboInOwl:hasDbXref "EMAPA:17249" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006871 ; owl:annotatedTarget "distal part of hindlimb bud" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011241 . (obo:UBERON_0004356 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006875 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006872 ; owl:annotatedTarget "An apical ectodermal ridge that is part of a handplate." . _:genid143156 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010130 _:genid143158 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003314 . _:genid143158 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001714, obo:UBERON_0002398 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0004576", "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006875 ; owl:annotatedTarget "The distal elements of the developing limb of vertebrates that will give rise to the manus (hand)." . [] oboInOwl:source "ncithesaurus:Hand_Plate" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006875 ; owl:annotatedTarget "UMLS:C1512334" . [] oboInOwl:hasDbXref "EMAPA:17245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006875 ; owl:annotatedTarget "distal part of forelimb bud" . _:genid143166 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000062, obo:UBERON_0005056 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006876 ; owl:annotatedTarget "A vasculature that is part of a organ." . [] oboInOwl:hasDbXref "FMA:74612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006876 ; owl:annotatedTarget "organ vasculature" . [] oboInOwl:hasDbXref "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." . [] oboInOwl:hasDbXref "FMA:74612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006876 ; owl:annotatedTarget "set of blood vessels of organ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "A vasculature that is part of a liver." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "the EHDAA2 term and the FMA term may not be exact equivalents - check" . [] oboInOwl:hasDbXref "FMA:73748" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "hepatic vasculature" . [] oboInOwl:hasDbXref "EMAPA:35501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "hepatic vascular element" . [] oboInOwl:hasDbXref "EMAPA:35501" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "liver vascular element" . [] oboInOwl:hasDbXref "PMID:21219184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "CDP" . [] oboInOwl:hasDbXref "EHDAA2:0003454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006877 ; owl:annotatedTarget "liver vascular system" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget obo:UBERON_0005253 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget _:genid144756 . [] oboInOwl:source "EHDAA2", "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget _:genid144758 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget "A head mesenchyme that develops_from a mesoderm." . [] oboInOwl:hasDbXref "EHDAA2:0001118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget "head mesenchyme from head mesoderm" . [] oboInOwl:hasDbXref "PMID:21219184" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001029 ; owl:annotatedTarget "pro-DCs" . [] oboInOwl:hasDbXref "EHDAA:1057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget "mesenchyme derived from head mesoderm" . [] oboInOwl:hasDbXref "UBERON:0005280" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget "cranial mesoderm" . [] oboInOwl:hasDbXref "AAO:0011051", "UBERON:0005280" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006904 ; owl:annotatedTarget "head mesoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006905 ; owl:annotatedTarget "Mesenchyme that is part of a mandibular prominence." . [] oboInOwl:hasDbXref "EMAPA:17357" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006905 ; owl:annotatedTarget "mesenchyme of mandibular process" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006905 ; owl:annotatedTarget "mesenchyme of mandibular prominence" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "3-hydroxy-GABA" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget _:genid144773 . [] oboInOwl:hasDbXref "DOI:10.1002/ajmg.a.32600", "Wikipedia:Ala_of_nose" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "The lateral surface parts of the external nose, inferiorly, surrounding the naris[EoM]." . [] oboInOwl:hasDbXref "FMA:59519" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "nasal ala" . [] oboInOwl:hasDbXref "Wikipedia:Ala_of_nose" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "ala nasi" . [] oboInOwl:hasDbXref "Wikipedia:Ala_of_nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "ala of the nose" . [] oboInOwl:hasDbXref "Wikipedia:Ala_of_nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "wing of nose" . [] oboInOwl:hasDbXref "Wikipedia:Ala_of_nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "wing of the nose" . [] oboInOwl:hasDbXref "Wikipedia:Ala_of_nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006906 ; owl:annotatedTarget "wings of the nose" . _:genid143210 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001555 ] ) ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001049 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "An anatomical space that surrounded_by a digestive tract." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "digestive tract lumen" . [] oboInOwl:hasDbXref "BTO:0000349" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "gut cavity" . [] oboInOwl:hasDbXref "FMA:45677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "gut lumen" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "lumen of alimentary tract" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "lumen of digestive tract" . [] oboInOwl:hasDbXref "FMA:45677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006909 ; owl:annotatedTarget "lumen of gut" . _:genid143222 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 _:genid143224 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004912 . _:genid143224 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001152, obo:UBERON_0001833 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006913 ; owl:annotatedTarget "An epithelium that is part of a lip." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005334" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:ZDB-PUB-060921-12" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006913 ; owl:annotatedTarget "The thick, high squamous-stratified epithelium that covers the lips. It contains abundant melanocytes, many mucous cells and has well differentiated taste buds.[TAO]" . [] oboInOwl:hasDbXref "Wikipedia:Squamous_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006914 ; owl:annotatedTarget "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." . _:genid143233 oboInOwl:external_ontology "FBbt" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006914 ; owl:annotatedTarget "FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 . [] oboInOwl:source "ncithesaurus:Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006914 ; owl:annotatedTarget "UMLS:C0221909" . _:genid143235 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000486 _:genid143237 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005258 . _:genid143237 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000076, obo:UBERON_0006246 . [] oboInOwl:hasDbXref "FMA:45563", "Wikipedia:Stratified_squamous_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006915 ; owl:annotatedTarget "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]." . [] oboInOwl:source "ncithesaurus:Stratified_Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006915 ; owl:annotatedTarget "UMLS:C0836131" . [] oboInOwl:hasDbXref "FMA:45563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006915 ; owl:annotatedTarget "epithelium stratificatum squamosum" . _:genid143246 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006916 ; owl:annotatedTarget "A non-keratinized stratified squamous epithelium that is part of a tongue." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001440 . (obo:UBERON_0006914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006919 ; owl:annotatedTarget "A squamous epithelium that is part of a tongue." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006919 ; owl:annotatedTarget "this is a singleton subclass of tongue epithelium in MA" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006919 ; owl:annotatedTarget "squamous epithelium of tongue" . _:genid143257 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043, obo:UBERON_0007832 . _:genid143259 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "A squamous epithelium that is part of a esophagus." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006210 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "MA introduces basal and squamous subtypes of esophagus epithelium; consider adding the FMA class 'epithelium of esophagus' here, because it is classified as squamous. BTO also has a singleton subclass" . [] oboInOwl:source "ncithesaurus:Esophageal_Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "UMLS:C1707950" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "esophageal squamous epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "squamous epithelium of esophagus" . [] oboInOwl:hasDbXref "MA:0001567" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006920 ; owl:annotatedTarget "squamous oesophageal epithelium" . (obo:UBERON_0006914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006921 ; owl:annotatedTarget "A squamous epithelium that is part of a stomach." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget obo:CL_0000120 . _:genid143274 oboInOwl:hasDbXref "http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006922 ; owl:annotatedTarget "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:source "ncithesaurus:Cervix_Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006922 ; owl:annotatedTarget "UMLS:C1707351" . _:genid143276 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006914 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006255 . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001031 ; owl:annotatedTarget "Granule cell that is part of the cerebellum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006923 ; owl:annotatedTarget "A squamous epithelium that is part of a vagina." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006923 ; owl:annotatedTarget "EMAPA:37794" . [] oboInOwl:source "ncithesaurus:Vaginal_Squamous_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006923 ; owl:annotatedTarget "UMLS:C1711259" . _:genid143285 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945, obo:UBERON_0007832 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006924 ; owl:annotatedTarget obo:UBERON_0006929 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006924 ; owl:annotatedTarget "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." . [] oboInOwl:hasDbXref "FMA:63458" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0006924 ; owl:annotatedTarget "epithelium of gastric gland" . _:genid143292 oboInOwl:hasDbXref "FMA:63458" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006924 ; owl:annotatedTarget "gastric gland epithelium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010056 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006925 ; owl:annotatedTarget "Any gland that is part of the digestive system." . [] oboInOwl:hasDbXref "BTO:0000345" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006925 ; owl:annotatedTarget "digestive gland" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "4-Amino-3-hydroxybutanoic acid" . ( ) . [] oboInOwl:hasDbXref "FMA:64800" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006929 ; owl:annotatedTarget "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]." . [] oboInOwl:source "ncithesaurus:Columnar_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006929 ; owl:annotatedTarget "UMLS:C0225337" . _:genid143311 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003107, obo:UBERON_0011953 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006931 ; owl:annotatedTarget "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." . [] oboInOwl:hasDbXref "EMAPA:27167" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006931 ; owl:annotatedTarget "stomach glandular region glandular mucous membrane" . _:genid143315 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 _:genid143317 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . _:genid143317 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001862, obo:UBERON_0006905 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006932 ; owl:annotatedTarget "An epithelium that is part of a vestibular labyrinth." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006932 ; owl:annotatedTarget "epithelium of vestibular labyrinth" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0000834" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006932 ; owl:annotatedTarget "inner ear vestibular component epithelium" . [] oboInOwl:hasDbXref "FMA:75606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006932 ; owl:annotatedTarget "vestibular sensory epithelium" . [] oboInOwl:hasDbXref "BTO:0000314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006934 ; owl:annotatedTarget "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." . _:genid143329 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006934 ; owl:annotatedTarget "note that the definition sourced from Dorlands say 'simple columnar', but FMA says atypical" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001032 ; owl:annotatedTarget "Granule cell that is part of the cerebral cortex." . [] oboInOwl:hasDbXref "BTO:0000314" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006934 ; owl:annotatedTarget "neuroepithelium" . _:genid143331 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002122 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000076 . ( ) . [] oboInOwl:hasDbXref "ISBN:0-8153-1691-7", "MGI:cwg", "MP:0002369" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006936 ; owl:annotatedTarget "The epithelial cells lining the capsule and trabeculae of the thymus." . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0003308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006937 ; owl:annotatedTarget "The epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals." . _:genid143344 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001757, obo:UBERON_0006268 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006938 ; owl:annotatedTarget "An epithelium that is part of a pinna." . _:genid143349 a owl:Restriction ; owl:onProperty obo:RO_0002202, core:channels_from ; owl:someValuesFrom obo:UBERON_0000924, obo:UBERON_0003959 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget _:genid144921 . [] oboInOwl:hasDbXref "Wikipedia:Efferent_ducts" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "The efferent ducts (or efferent ductules or ductuli efferentes) connect the rete testis with the initial section of the epididymis. The ductuli are unilaminar and composed of columnar ciliated and non-ciliated (absorptive) cells. The ciliated cells serve to stir the luminal fluids, possibly to help ensure homogeneous absorption of water from the fluid produced by the testis, which results in an increase in the concentration of luminal sperm. The epithelium is surrounded by a band of smooth muscle that helps to propel the sperm toward the epididymis." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010532" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "Any of a group ranging from one to twelve (varies in species) small seminal ducts per testis which transport sperm from the testes to the kidney.[AAO]" . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "Check EMAPA" . [] oboInOwl:source "ncithesaurus:Efferent_Ductule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "UMLS:C0228013" . [] oboInOwl:hasDbXref "FMA:19081", "Wikipedia:Efferent_ducts" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "efferent ductule" . _:genid143357 oboInOwl:hasDbXref "Wikipedia:Efferent_ducts" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "ductuli efferentes testis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011156 . [] oboInOwl:hasDbXref "AAO:0010532", "Wikipedia:Efferent_ducts" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006946 ; owl:annotatedTarget "vasa efferentia" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006947 ; owl:annotatedTarget _:genid144934 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006947 ; owl:annotatedTarget "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0006947 ; owl:annotatedTarget "in FMA includes as parts: seminal vesicle, efferent ductule (vas efferentia), epididymis, deferent duct (vas deferens), ejaculatory duct" . [] oboInOwl:hasDbXref "ZFA:0001268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006947 ; owl:annotatedTarget "sperm duct" . [] oboInOwl:hasDbXref "TAO:0001268" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006947 ; owl:annotatedTarget "sperm ducts" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006948 ; owl:annotatedTarget "An epithelium that is part of a efferent duct." . [] oboInOwl:hasDbXref "FMA:19195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006948 ; owl:annotatedTarget "epithelium of efferent ductule of testis" . [] oboInOwl:hasDbXref "PMID:1238970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006953 ; owl:annotatedTarget "The ejaculatory duct epithelium is composed of cuboidal to columnar cells between or through which project the terminal parts of the ducts of the unicellular prostate glands." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001033 ; owl:annotatedTarget "Granule cell with a soma found in the hippocampus." . _:genid143380 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995, obo:UBERON_0011997 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006955 ; owl:annotatedTarget "An epithelium that is part of a uterus." . [] oboInOwl:hasDbXref "BTO:0003082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006955 ; owl:annotatedTarget "uterus epithelium" . _:genid143386 oboInOwl:hasDbXref "http://www.medterms.com/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006956 ; owl:annotatedTarget "The inner lining of the cheeks and lips." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004141 . [] oboInOwl:source "ncithesaurus:Buccal_Mucosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006956 ; owl:annotatedTarget "UMLS:C1578559" . _:genid143388 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006298 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005498 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006957 ; owl:annotatedTarget "An epithelium that is part of a submandibular gland primordium." . [] oboInOwl:hasDbXref "EMAPA:17756" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006957 ; owl:annotatedTarget "submaxillary gland primordium epithelium" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget _:genid144973 . [] oboInOwl:hasDbXref "Wikipedia:Stroma_of_ovary" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "4-amino-3-hydroxybutyric acid" . [] oboInOwl:source "ncithesaurus:Stroma_of_the_Ovarian_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "UMLS:C0737271" . [] oboInOwl:hasDbXref "FMA:18626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "interstitial tissue of ovary" . [] oboInOwl:hasDbXref "FMA:18626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "ovarian stroma" . [] oboInOwl:hasDbXref "MA:0002991" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "ovary stroma" . [] oboInOwl:hasDbXref "Wikipedia:Stroma_of_ovary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "stroma of the ovary" . [] oboInOwl:hasDbXref "FMA:18626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "stroma ovarica" . [] oboInOwl:hasDbXref "Wikipedia:Stroma_of_ovary" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006960 ; owl:annotatedTarget "stroma ovarii" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget obo:UBERON_0000483 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget _:genid144984 . [] oboInOwl:hasDbXref "Dorlands_Medical_Dictionary:MerckSource", "Wikipedia:Pars_distalis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "The distal part of adenohypophysis: the part that makes up the main body of the gland." . _:genid143410 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010542" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "Region of the adenohypophysis which produces the follicle-stimulating hormone, luteinizing hormone, prolactin, thyrotropin, and adrenocorticotropin.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000244" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/", "http://www.thefreedictionary.com/pars+anterior" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "The anterior part of the adenohypophysis. [TFD][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000244" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" . [] oboInOwl:hasDbXref "BIRNLEX:1022", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "DHP" . [] oboInOwl:hasDbXref "EHDAA2:0001416", "MA:0000854", "ZFA:0001195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars anterior" . [] oboInOwl:source "BIRNLEX:1022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "UMLS:C0175322" . [] oboInOwl:source "BIRNLEX:1022" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "neuronames:410" . _:genid143417 oboInOwl:hasDbXref "BIRNLEX:1022" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "distal part of hypophysis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327 . [] oboInOwl:hasDbXref "FMA:74630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars anterior of adenohypophysis" . [] oboInOwl:hasDbXref "FMA:74630", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis (glandula pituitaria)" . [] oboInOwl:hasDbXref "FMA:74630", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis adenohypophysis" . [] oboInOwl:hasDbXref "FMA:74630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis of anterior lobe of pituitary gland" . [] oboInOwl:hasDbXref "FMA:74630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars glandularis of adenohypophysis" . [] oboInOwl:hasDbXref "MA:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "anterior lobe" . [] oboInOwl:hasDbXref "NeuroNames:410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "distal part of the hypophysis" . [] oboInOwl:hasDbXref "MA:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis" . [] oboInOwl:hasDbXref "NeuroNames:410" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis (hypophysis)" . [] oboInOwl:hasDbXref "BTO:0001787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis adenohypophyseos" . [] oboInOwl:hasDbXref "BTO:0001787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars distalis lobi anterioris hypophyseos" . [] oboInOwl:hasDbXref "MA:0000854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0006964 ; owl:annotatedTarget "pars glandularis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001035 ; owl:annotatedTarget obo:CL_0000548 . _:genid143434 oboInOwl:hasDbXref "GO:0072360", "ZFA:0005077" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006965 ; owl:annotatedTarget "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006289 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006966 ; owl:annotatedTarget _:genid145016 . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001035 ; owl:annotatedTarget "A connective tissue cell found in bone." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006966 ; owl:annotatedTarget "A capillary that is part of the coronary system." . [] oboInOwl:hasDbXref "GO:0003248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0006966 ; owl:annotatedTarget "heart capillary" . [] oboInOwl:hasDbXref "FMA:9658", "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006983 ; owl:annotatedTarget "Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface." . _:genid143443 oboInOwl:notes "via morphological boundary in CARO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0006984 ; owl:annotatedTarget obo:UBERON_0010199 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 . [] oboInOwl:hasDbXref "CARO:0001002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0006984 ; owl:annotatedTarget "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n." . [] oboInOwl:source "ncithesaurus:Anatomic_Surface" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0006984 ; owl:annotatedTarget "UMLS:C1515977" . [] oboInOwl:hasDbXref "XAO:0000235", "http://www.drugs.com/dict/cardiogenic-mesoderm.html", "https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." . [] oboInOwl:hasDbXref "EHDAA2:0000214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "cardiogenic splanchnopleure" . _:genid143452 oboInOwl:hasDbXref "XAO:0000235" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "cardiac mesoderm" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/cardiogenic-mesoderm.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "cardiogenic mesoderm" . _:genid143454 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "cardiogenic region" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006291 . [] oboInOwl:hasDbXref "XAO:0000235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007005 ; owl:annotatedTarget "heart primordia" . _:genid143462 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007010 ; owl:annotatedTarget "Organism at the cleavage stage." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 . (obo:UBERON_0000468 [ a owl:Restriction ; owl:onProperty obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000112 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002493 ; owl:someValuesFrom obo:UBERON_0000112 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007021 ; owl:annotatedTarget "A multicellular organism that is at the juvenile stage." . _:genid143471 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002047" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007021 ; owl:annotatedTarget "Whole organism that is not fully grown or sexually mature.[TAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003322 . [] oboInOwl:hasDbXref "BILA:0000076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007021 ; owl:annotatedTarget "juvenile organism" . [] oboInOwl:hasDbXref "TAO:0002047" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007021 ; owl:annotatedTarget "juveniles" . _:genid143476 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002489 ; owl:someValuesFrom obo:UBERON_0000113, obo:UBERON_0005602 . _:genid143478 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002493 ; owl:someValuesFrom obo:UBERON_0000113, obo:UBERON_0004872 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007023 ; owl:annotatedTarget "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002046" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007023 ; owl:annotatedTarget "Whole organism that is fully grown or sexually mature.[TAO]" . [] oboInOwl:source "ncithesaurus:Adult" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007023 ; owl:annotatedTarget "UMLS:C0001675" . [] oboInOwl:hasDbXref "TAO:0002046" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007023 ; owl:annotatedTarget "adults" . _:genid143490 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002488 ; owl:someValuesFrom obo:UBERON_0000109, obo:UBERON_0001686 . [] oboInOwl:source "NCBIBook:NBK10107" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0007026 ; owl:annotatedTarget "The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis" . _:genid143492 oboInOwl:source "ncithesaurus:Primordial_Gut" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007026 ; owl:annotatedTarget "UMLS:C1514442" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005689 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007098 ; owl:annotatedTarget obo:UBERON_0003099 . _:genid143498 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007098 ; owl:annotatedTarget _:genid145076 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006210 . [] oboInOwl:hasDbXref "ZFA:0007064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007098 ; owl:annotatedTarget "Cranial neural crest that migrates into the mandibular arch." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16080 ; owl:annotatedTarget "GABOB" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007099 ; owl:annotatedTarget obo:UBERON_0003099 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007099 ; owl:annotatedTarget _:genid145080 . [] oboInOwl:hasDbXref "ZFA:0007065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007099 ; owl:annotatedTarget "Cranial neural crest that migrates into the hyoid arch." . [] oboInOwl:hasDbXref "XAO:0000025" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007099 ; owl:annotatedTarget "hyoid crest" . [] oboInOwl:notes "GO uses blood circulation generically to include the haemolymphatic fluid of arthropods" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007100 ; owl:annotatedTarget _:genid145089 . [] oboInOwl:hasDbXref "GO:0007507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007100 ; owl:annotatedTarget "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." . [] oboInOwl:hasDbXref "Wikipedia:Heart" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007100 ; owl:annotatedTarget "dorsal tube" . [] oboInOwl:hasDbXref "GO:0007507" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007100 ; owl:annotatedTarget "heart" . [] oboInOwl:hasDbXref "FBbt:00003154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007100 ; owl:annotatedTarget "adult heart" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Deciduous_teeth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007115 ; owl:annotatedTarget "One of the first set of teeth in the growth development of humans and many other mammals[WP]." . [] oboInOwl:source "ncithesaurus:Temporary_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007115 ; owl:annotatedTarget "UMLS:C0040455" . [] oboInOwl:hasDbXref "FMA:55655" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007115 ; owl:annotatedTarget "primary tooth" . [] oboInOwl:hasDbXref "FMA:55655" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007115 ; owl:annotatedTarget "temporary tooth" . [] oboInOwl:hasDbXref "Wikipedia:Deciduous_teeth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007115 ; owl:annotatedTarget "dentes decidui" . [] oboInOwl:hasDbXref "MESH:A14.254.245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "The set of teeth first in order or time of development that will be replaced by permanent dentition upon their loss." . [] oboInOwl:hasDbXref "FMA:75151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "baby teeth" . [] oboInOwl:hasDbXref "FMA:75151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "deciduous teeth" . [] oboInOwl:hasDbXref "FMA:75151", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "dentes decidui" . [] oboInOwl:hasDbXref "FMA:75151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "milk teeth" . [] oboInOwl:hasDbXref "FMA:75151", "GAID:1266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "primary teeth" . [] oboInOwl:hasDbXref "FMA:75151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "set of deciduous teeth" . [] oboInOwl:hasDbXref "FMA:75151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "set of primary teeth" . [] oboInOwl:hasDbXref "GAID:1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007116 ; owl:annotatedTarget "deciduous dentition" . [] oboInOwl:hasDbXref "MESH:A01.047.849", "Wikipedia:Navel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007118 ; owl:annotatedTarget "The pit in the center of the abdominal wall marking the point where the umbilical cord entered in the fetus." . [] oboInOwl:source "ncithesaurus:Umbilicus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007118 ; owl:annotatedTarget "UMLS:C0041638" . [] oboInOwl:hasDbXref "FMA:61584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007118 ; owl:annotatedTarget "navel" . [] oboInOwl:hasDbXref "FMA:61584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007118 ; owl:annotatedTarget "umbilical part of abdomen" . [] oboInOwl:hasDbXref "FMA:61584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007118 ; owl:annotatedTarget "umbilical region" . [] oboInOwl:hasDbXref "Wikipedia:Femur_neck" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward." . [] oboInOwl:source "ncithesaurus:Femoral_Neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "UMLS:C0015815" . [] oboInOwl:hasDbXref "FMA:42385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "femoral neck" . [] oboInOwl:hasDbXref "Wikipedia:Femur_neck" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "collum femoris" . [] oboInOwl:hasDbXref "Wikipedia:Femur_neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "femur neck" . [] oboInOwl:hasDbXref "Wikipedia:Femur_neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007119 ; owl:annotatedTarget "neck of the femur" . [] oboInOwl:editor_note "cardinality not allowed with transitivity in OWL" ; oboInOwl:min_count "2" ; oboInOwl:taxon_notes "some premolars may have 3 cusps" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget _:genid145131 . _:genid143551 oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "The premolar teeth or bicuspids are transitional teeth located between the canine and molar teeth." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001643 . [] oboInOwl:notes "Although there are a few exceptions, the dental formula for the great majority of cricetids is 1.0.0.3" ; oboInOwl:source "Wikipedia:Cricetidae" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget obo:NCBITaxon_337687 . _:genid143553 oboInOwl:source "ncithesaurus:Bicuspid_Tooth" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "UMLS:C1704302" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002397 . [] oboInOwl:hasDbXref "FMA:55637" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "secondary premolar tooth" . _:genid143555 oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "bicuspid" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001603 . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "bicuspid teeth" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "bicuspid tooth" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "bicuspids" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "biscuspid" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "dens premolaris" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "dentes premolares" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "mandibular bicuspid" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "maxillary bicuspid" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "maxillary premolar" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "pm3 (dentistry)" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "praemolares" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "premolar" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "premolar teeth" . _:genid143569 oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "premolar tooth" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001644 . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001044 ; owl:annotatedTarget "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "premolars" . [] oboInOwl:hasDbXref "Wikipedia:Premolar" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007120 ; owl:annotatedTarget "præmolares" . _:genid143572 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004117 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003066 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0004362 ] ) ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0010230 . [] oboInOwl:hasDbXref "ISBN:0124020607", "PMID:16313389", "VHOG:0000970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "A pharyngeal pouch that is between pharyngeal arches 1 and 2." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000970" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget ". [][VHOG]" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001044 ; owl:annotatedTarget "effector CD4+ T cell" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000970" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.semcdb.2010.01.022 Grevellec A, Tucker AS, The pharyngeal pouches and clefts: development, evolution, structure and derivatives. Seminars in Cell and Developmental Biology (2010)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "In all jawed vertebrates the first arch forms the jaw, while the second arch forms the hyoid apparatus. These two arches are separated by the first pharyngeal pouch and cleft.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "The endoderm lines the future auditory tube (Pharyngotympanic Eustachian tube) , middle ear, mastoid antrum, and inner layer of the tympanic membrane. & origin of Mandibular nerve & Maxillary artery" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "we use adjacency relations rather than part_of, as in EHDAA2." . [] oboInOwl:source "ncithesaurus:First_Pharyngeal_Pouch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "UMLS:C0231068" . [] oboInOwl:hasDbXref "EHDAA2:0000013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "1st arch branchial pouch" . [] oboInOwl:hasDbXref "EHDAA2:0000016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "1st arch branchial pouch endoderm" . [] oboInOwl:hasDbXref "EHDAA2:0000016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "1st arch pouch endoderm" . [] oboInOwl:hasDbXref "VHOG:0000555" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "1st pharyngeal pouch endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "first arch pharyngeal pouch" . [] oboInOwl:hasDbXref "XAO:0000102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "first visceral pouch" . [] oboInOwl:hasDbXref "ZFA:0001128" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "pharyngeal pouches 1" . [] oboInOwl:hasDbXref "XAO:0000102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "visceral pouch 1" . [] oboInOwl:hasDbXref "VHOG:0000970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007122 ; owl:annotatedTarget "first pharyngeal pouch" . [] oboInOwl:hasDbXref "ISBN:0124020607", "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "A pharyngeal puch that is between the pharyngeal arches 2 and 3." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000967" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "A pouch that is situated between the 2nd and 3rd pharyngeal arch. [ISBN:0124020607][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011115" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-226-55763-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "Second of the pharyngeal (endodermal) evaginations between the visceral arches from which the Eustachian tube is derived; pouches 2-4 open as gill slits.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000967" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "Contributes to the middle ear, epithelial lining of Crypts (spaces) of the palatine tonsils, supplied by the facial nerve" . [] oboInOwl:source "ncithesaurus:Second_Pharyngeal_Pouch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "UMLS:C0231069" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0000060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "2nd arch branchial pouch" . [] oboInOwl:hasDbXref "EHDAA2:0000061" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "2nd arch branchial pouch endoderm" . [] oboInOwl:hasDbXref "EHDAA2:0000058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "2nd arch pouch endoderm" . [] oboInOwl:hasDbXref "VHOG:0000561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "2nd pharyngeal pouch endoderm" . [] oboInOwl:hasDbXref "ZFA:0001130" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "pharyngeal pouches 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "second arch pharyngeal pouch" . [] oboInOwl:hasDbXref "XAO:0000247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "second visceral pouch" . [] oboInOwl:hasDbXref "XAO:0000247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "visceral pouch 2" . [] oboInOwl:hasDbXref "VHOG:0000967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007123 ; owl:annotatedTarget "second pharyngeal pouch" . [] oboInOwl:hasDbXref "ISBN:0124020607", "PMID:16313389", "Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "A pharyngeal pouch that between pharyngeal arches 3 and 4." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000966" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "A pouch that is situated between the 3rd and 4th pharyngeal arch. [ISBN:0124020607][VHOG]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0011116" ; oboInOwl:ontology "AAO" ; oboInOwl:source "ISBN:0-226-55763-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "Third of the pharyngeal (endodermal) evaginations between the visceral arches from which the Eustachian tube is derived; pouches 2-4 open as gill slits.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000966" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000011 ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "The third pouch possesses Dorsal and Ventral wings. Derivatives of the dorsal wings include the inferior parathyroid glands, while the ventral wings fuse to form the cytoreticular cells of the thymus. The main nerve supply to the derivatives of this pouch is Cranial Nerve IX, glossopharyngeal nerve" . [] oboInOwl:source "ncithesaurus:Third_Pharyngeal_Pouch" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "UMLS:C0231070" . [] oboInOwl:hasDbXref "RETIRED_EHDAA2:0000076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "3rd arch branchial pouch" . [] oboInOwl:hasDbXref "EHDAA2:0000077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "3rd arch branchial pouch endoderm" . [] oboInOwl:hasDbXref "VHOG:0001030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "3rd pharyngeal pouch endoderm" . [] oboInOwl:hasDbXref "ZFA:0001131" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "pharyngeal pouches 3" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "third arch pharyngeal pouch" . [] oboInOwl:hasDbXref "XAO:0000251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "third visceral pouch" . [] oboInOwl:hasDbXref "XAO:0000251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "visceral pouch 3" . [] oboInOwl:hasDbXref "VHOG:0000966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007124 ; owl:annotatedTarget "third pharyngeal pouch" . [] oboInOwl:hasDbXref "ISBN:0815318960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007128 ; owl:annotatedTarget "Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm." . [] oboInOwl:hasDbXref "XAO:0000110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007128 ; owl:annotatedTarget "corpuscle" . [] oboInOwl:hasDbXref "XAO:0000110" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007128 ; owl:annotatedTarget "glomerulus" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007134 ; owl:annotatedTarget "Ganglion which is located in the trunk." . [] oboInOwl:hasDbXref "MAT:0000344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007134 ; owl:annotatedTarget "body ganglion" . [] oboInOwl:hasDbXref "ZFA:0001573" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007134 ; owl:annotatedTarget "trunk ganglia" . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-961014-576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007135 ; owl:annotatedTarget "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000131" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007135 ; owl:annotatedTarget "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007135 ; owl:annotatedTarget "presumptive central nervous system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007142 ; owl:annotatedTarget "An internal carotid artery that branching_part_of a left common carotid artery plus branches." . [] oboInOwl:hasDbXref "FMA:4062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007142 ; owl:annotatedTarget "arteria caritis interna sinistra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007143 ; owl:annotatedTarget "An internal carotid artery that branching_part_of a right common carotid artery plus branches." . [] oboInOwl:hasDbXref "FMA:3949" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007143 ; owl:annotatedTarget "arteria carotis interna dextra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007144 ; owl:annotatedTarget "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail." . [] oboInOwl:hasDbXref "FMA:85540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007144 ; owl:annotatedTarget "embryo tail" . [] oboInOwl:hasDbXref "FMA:85540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007144 ; owl:annotatedTarget "tail of embryo" . [] oboInOwl:hasDbXref "FMA:85540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007144 ; owl:annotatedTarget "embryonic tail" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007147 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a midgut." . [] oboInOwl:hasDbXref "FMA:54366" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007147 ; owl:annotatedTarget "midgut lumen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007148 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a hindgut." . [] oboInOwl:hasDbXref "FMA:54367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007148 ; owl:annotatedTarget "hindgut lumen" . [] oboInOwl:source "FMA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget _:genid145271 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "A valve leafleft that is part of a mitral valve." . [] oboInOwl:source "FMA:7241" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "Leaf of cardiac valve which has as its parts the anterior, and posterior leaflets that is attached to the chorda tendinea of left ventricle and to the frbrous ring of mitral valve." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000822" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "FMA:7241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "leaflet of mitral valve" . [] oboInOwl:hasDbXref "FMA:7241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "mitral valve leaflet" . [] oboInOwl:hasDbXref "FMA:7241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "mitral valvular leaflet" . [] oboInOwl:hasDbXref "VHOG:0000822" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007151 ; owl:annotatedTarget "mitral valve leaflets" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_thyroid_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007156 ; owl:annotatedTarget "The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins." . [] oboInOwl:hasDbXref "FMA:4728" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007156 ; owl:annotatedTarget "inferior thyroid venous tree" . [] oboInOwl:hasDbXref "FMA:4728" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007156 ; owl:annotatedTarget "vena thyroidea inferioris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007158 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a anal canal." . [] oboInOwl:hasDbXref "FMA:17357" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007158 ; owl:annotatedTarget "anal canal lumen" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001050 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." . _:genid143710 a owl:Restriction ; owl:onProperty obo:RO_0002373, obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0001155, obo:UBERON_0004302 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007159 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a colon." . [] oboInOwl:hasDbXref "FMA:18374" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007159 ; owl:annotatedTarget "colon lumen" . _:genid143715 oboInOwl:hasDbXref "FMA:18374" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007159 ; owl:annotatedTarget "colonic lumen" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002420 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007160 ; owl:annotatedTarget obo:UBERON_0017635 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_petrosal_sinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007160 ; owl:annotatedTarget "The inferior petrosal sinus, within the human head, is an area beneath the brain, which allows blood veins to span the area, from the center of the head downward. It drains from the cavernous sinus (beneath the brain) to the sigmoid sinuses above the internal jugular vein." . [] oboInOwl:hasDbXref "FMA:50770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007160 ; owl:annotatedTarget "sinus petrosal inferior" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001050 ; owl:annotatedTarget "effector CD8+ T cell" . [] oboInOwl:hasDbXref "FMA:23797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007171 ; owl:annotatedTarget "scapular border" . [] oboInOwl:hasDbXref "FMA:23800" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007172 ; owl:annotatedTarget "scapular angle" . [] oboInOwl:source "EMAPA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget obo:UBERON_0007171 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget obo:UBERON_0007174 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_border_of_the_scapula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "The lateral border (or axillary border, or margin) is the thickest of the three borders of the scapula. It begins above at the lower margin of the glenoid cavity, and inclines obliquely downward and backward to the inferior angle. Immediately below the glenoid cavity is a rough impression, the infraglenoid tuberosity, about 2.5 cm. in length, which gives origin to the long head of the Triceps brachii; in front of this is a longitudinal groove, which extends as far as the lower third of this border, and affords origin to part of the Subscapularis. The inferior third is thin and sharp, and serves for the attachment of a few fibers of the Teres major behind, and of the Subscapularis in front." . [] oboInOwl:hasDbXref "FMA:23239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "axillary border of scapula" . [] oboInOwl:hasDbXref "FMA:23239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "lateral border of scapula" . [] oboInOwl:hasDbXref "FMA:23239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "margo lateralis (scapula)" . [] oboInOwl:hasDbXref "FMA:23239", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "margo lateralis scapulae" . [] oboInOwl:hasDbXref "FMA:23239" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007173 ; owl:annotatedTarget "lateral part of scapula" . [] oboInOwl:source "EMAPA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget obo:UBERON_0007171 . [] oboInOwl:source "PMID:20136669" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget _:genid145319 . [] oboInOwl:hasDbXref "Wikipedia:Medial_border_of_scapula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "The medial border of the scapula (vertebral border, medial margin) is the longest of the three borders, and extends from the medial to the inferior angle. It is arched, intermediate in thickness between the superior and the axillary borders, and the portion of it above the spine forms an obtuse angle with the part below. This border presents an anterior and a posterior lip, and an intermediate narrow area. The anterior lip affords attachment to the Serratus anterior; the posterior lip, to the Supraspinatus above the spine, the Infraspinatus below; the area between the two lips, to the Levator scapulC& above the triangular surface at the commencement of the spine, to the Rhomboideus minor on the edge of that surface, and to the Rhomboideus major below it; this last is attached by means of a fibrous arch, connected above to the lower part of the triangular surface at the base of the spine, and below to the lower part of the border." . [] oboInOwl:hasDbXref "FMA:23242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "margo medialis (scapula)" . [] oboInOwl:hasDbXref "FMA:23242", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "margo medialis scapulae" . [] oboInOwl:hasDbXref "FMA:23242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "medial part of scapula" . [] oboInOwl:hasDbXref "FMA:23242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "vertebral border of scapula" . [] oboInOwl:hasDbXref "Wikipedia:Medial_border_of_scapula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "medial border of the scapula" . [] oboInOwl:hasDbXref "Wikipedia:Medial_border_of_scapula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "medial margin of the scapula" . [] oboInOwl:hasDbXref "Wikipedia:Medial_border_of_scapula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "vertebral border" . [] oboInOwl:hasDbXref "Wikipedia:Medial_border_of_scapula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007174 ; owl:annotatedTarget "vertebral border of the scapula" . [] oboInOwl:source "EMAPA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007175 ; owl:annotatedTarget obo:UBERON_0007172 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_angle_of_scapula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007175 ; owl:annotatedTarget "An angle of the scapula formed by the union of the vertebral and axillary borders; its dorsal surface affords attachment to the Teres major and frequently to a few fibers of the Latissimus dorsi.[WP,unvetted]." . [] oboInOwl:hasDbXref "FMA:13315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007175 ; owl:annotatedTarget "angulus inferior (scapula)" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_angle_of_scapula" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007175 ; owl:annotatedTarget "angulus inferior scapulae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007177 ; owl:annotatedTarget "A lamina propria that is part of a colonic mucosa." . [] oboInOwl:hasDbXref "FMA:15657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007177 ; owl:annotatedTarget "colonic lamina propria" . [] oboInOwl:hasDbXref "FMA:15657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007177 ; owl:annotatedTarget "lamina propria mucosae of colon" . [] oboInOwl:hasDbXref "FMA:15657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007177 ; owl:annotatedTarget "lamina propria of colonic mucosa" . [] oboInOwl:hasDbXref "FMA:15657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007177 ; owl:annotatedTarget "lamina propria of colonic mucous membrane" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007181 ; owl:annotatedTarget "A serous membrane that is part of a uterine tube infundibulum." . [] oboInOwl:hasDbXref "FMA:18324" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007181 ; owl:annotatedTarget "serosa of infundibulum of fallopian tube" . [] oboInOwl:hasDbXref "FMA:18324" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007181 ; owl:annotatedTarget "serosa of infundibulum of oviduct" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001053 ; owl:annotatedTarget "A memory B cell that lacks expression of surface IgD." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007182 ; owl:annotatedTarget "A muscle layer that is part of a uterine tube infundibulum." . [] oboInOwl:hasDbXref "FMA:18336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007182 ; owl:annotatedTarget "muscle layer of infundibulum of fallopian tube" . [] oboInOwl:hasDbXref "FMA:18336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007182 ; owl:annotatedTarget "muscle layer of infundibulum of oviduct" . [] oboInOwl:hasDbXref "FMA:18336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007182 ; owl:annotatedTarget "muscularis of infundibulum of uterine tube" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001053 ; owl:annotatedTarget "IgD- memory B cell" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007188 ; owl:annotatedTarget "A mesothelium that is part of a serous pericardium." . [] oboInOwl:hasDbXref "FMA:18149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007188 ; owl:annotatedTarget "mesothelium of pericardium" . [] oboInOwl:hasDbXref "FMA:18149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007188 ; owl:annotatedTarget "pericardial mesothelium" . [] oboInOwl:hasDbXref "FMA:18149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007188 ; owl:annotatedTarget "serous pericardium mesothelium" . [] oboInOwl:hasDbXref "Wikipedia:Bone_marrow#Stroma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007195 ; owl:annotatedTarget "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." . [] oboInOwl:hasDbXref "FMA:21426" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007195 ; owl:annotatedTarget "bone marrow stroma" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007196 ; owl:annotatedTarget _:genid145380 . [] oboInOwl:hasDbXref "Wikipedia:Tracheobronchial_tree" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007196 ; owl:annotatedTarget "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." . [] oboInOwl:hasDbXref "FMA:7393", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007196 ; owl:annotatedTarget "arbor tracheobronchialis" . [] oboInOwl:hasDbXref "HP:0005607" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007196 ; owl:annotatedTarget "tracheobronchial system" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "CAS:14383-50-7" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007197 ; owl:annotatedTarget "Multicellular organism that can produce both male and female gametes." . _:genid143801 oboInOwl:hasDbXref "BILA:0000029" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007197 ; owl:annotatedTarget "dioecious organism" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001009 . [] oboInOwl:hasDbXref "WBbt:0007849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007197 ; owl:annotatedTarget "hermaphrodite" . _:genid143803 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014402 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007197 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002465 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-4422-9726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007198 ; owl:annotatedTarget "An anatomical structure present only in hermaphrodites." . [] oboInOwl:hasDbXref "WBbt:0005758" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007198 ; owl:annotatedTarget "hermaphrodite-specific" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007204 ; owl:annotatedTarget "The vasculature consisting of brachiocephalic arteries and veins." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007213 ; owl:annotatedTarget obo:UBERON_0005253 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007213 ; owl:annotatedTarget "Mesenchyme that develops_from a cranial neural crest." . [] oboInOwl:hasDbXref "EHDAA2:0000735" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007213 ; owl:annotatedTarget "head mesenchyme from neural crest" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007214 ; owl:annotatedTarget "Mesenchyme that develops_from a trunk neural crest." . [] oboInOwl:hasDbXref "EHDAA2:0002093" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007214 ; owl:annotatedTarget "trunk mesenchyme from neural crest" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "An embryo stage that covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." . [] oboInOwl:hasDbXref "MIAA:0000399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "embryo late (growth) stage" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "fetal stage" . [] oboInOwl:hasDbXref "MIAA:0000399" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "fetus" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "fetus stage" . [] oboInOwl:hasDbXref "BTO:0000449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "embryo late growth stage" . [] oboInOwl:hasDbXref "BTO:0000449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007220 ; owl:annotatedTarget "embryo late stage" . [] oboInOwl:hasDbXref "http://www.innerbody.com/image_nerv14/nerv175.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007223 ; owl:annotatedTarget "The osseous cochlea is the bony foundation that forms the small shell arrangement for the cochlear nerve." . [] oboInOwl:hasDbXref "Wikipedia:Vestibular_nuclei", "http://www.sciencedirect.com/science/article/pii/S0079612305510069", "https://github.com/geneontology/go-ontology/issues/9028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007228 ; owl:annotatedTarget "A cranial nucleus for the vestibular nerve. [WP,unvetted]." . [] oboInOwl:source "ncithesaurus:Vestibular_Nucleus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007228 ; owl:annotatedTarget "UMLS:C0042600" . [] oboInOwl:hasDbXref "MA:0001032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007228 ; owl:annotatedTarget "vestibular VIII nucleus" . [] oboInOwl:hasDbXref "FMA:54602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007228 ; owl:annotatedTarget "vestibular nucleus of acoustic nerve" . [] oboInOwl:hasDbXref "FMA:54602" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007228 ; owl:annotatedTarget "vestibular nucleus of eighth cranial nerve" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007237 ; owl:annotatedTarget _:genid145432 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000510" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007237 ; owl:annotatedTarget "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007237 ; owl:annotatedTarget "ventral pharyngeal arch 1" . [] oboInOwl:hasDbXref "VHOG:0000510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007237 ; owl:annotatedTarget "ventral mandibular arch" . [] oboInOwl:hasDbXref "VHOG:0000510" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007237 ; owl:annotatedTarget "ventral visceral arch 1" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007238 ; owl:annotatedTarget _:genid145439 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000511" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007238 ; owl:annotatedTarget "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007239 ; owl:annotatedTarget "A tunica media that is part of a artery." . [] oboInOwl:source "ncithesaurus:Venous_System_Smooth_Muscle_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007239 ; owl:annotatedTarget "UMLS:C1710627" . [] oboInOwl:hasDbXref "EV:0100029" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007239 ; owl:annotatedTarget "arterial media" . [] oboInOwl:hasDbXref "FMA:14273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007239 ; owl:annotatedTarget "tunica media (arteriae)" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007240 ; owl:annotatedTarget _:genid145456 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007240 ; owl:annotatedTarget "A tunica adventitia that is part of a artery." . [] oboInOwl:hasDbXref "EV:0100030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007240 ; owl:annotatedTarget "arterial adventitia" . [] oboInOwl:hasDbXref "FMA:14274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007240 ; owl:annotatedTarget "tunica externa (adventitia)(arteriae)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007241 ; owl:annotatedTarget "A tunica adventitia that is part of a vein." . [] oboInOwl:hasDbXref "FMA:14355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007241 ; owl:annotatedTarget "tunica externa (adventitia)(venae)" . [] oboInOwl:hasDbXref "EV:0100034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007241 ; owl:annotatedTarget "venous adventitia" . _:genid143884 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007242 ; owl:annotatedTarget "A tunica intima that is part of a vein." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000012 . [] oboInOwl:hasDbXref "FMA:14353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007242 ; owl:annotatedTarget "tunica interna (intima)(venae)" . [] oboInOwl:hasDbXref "EV:0100032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007242 ; owl:annotatedTarget "venous intima" . [] oboInOwl:hasDbXref "GOC:add", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001054 ; owl:annotatedTarget "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007243 ; owl:annotatedTarget "A tunica media that is part of a vein." . [] oboInOwl:hasDbXref "FMA:14354" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007243 ; owl:annotatedTarget "tunica media (venae)" . [] oboInOwl:hasDbXref "EV:0100033" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007243 ; owl:annotatedTarget "venous media" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007245 ; owl:annotatedTarget "Gray matter of the central nervous system which is a collection of clustered nuclei." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "Gmelin:2031" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:CL_0001054 ; owl:annotatedTarget "monocyte" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007247 ; owl:annotatedTarget "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei." . [] oboInOwl:hasDbXref "FMA:72246" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007247 ; owl:annotatedTarget "superior olivary complex nucleus" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007250 ; owl:annotatedTarget _:genid145494 . [] oboInOwl:hasDbXref "MGI:cwg", "MP:0002385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007250 ; owl:annotatedTarget "The lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue." . [] oboInOwl:source "ncithesaurus:Lingual_Tonsil" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007250 ; owl:annotatedTarget "UMLS:C0229871" . [] oboInOwl:hasDbXref "MA:0000773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007250 ; owl:annotatedTarget "lingual tonsillar tissue" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_tonsils" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007250 ; owl:annotatedTarget "tonsilla lingualis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007252 ; owl:annotatedTarget "An intervertebral disk that is part of a cervical region of vertebral column. A cervical intervertebral disk connects at least one cervical vertebra, either to another cervical vertebra, or at one point on the vertebral colummn, to a thoracic vertebra." . [] oboInOwl:hasDbXref "FMA:13895" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007252 ; owl:annotatedTarget "cervical intervertebral disc" . [] oboInOwl:hasDbXref "EMAPA:19415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007252 ; owl:annotatedTarget "intervertebral disc of cervical region" . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007254 ; owl:annotatedTarget "An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connects at least one thoracic vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a lumbar vertebra." . [] oboInOwl:hasDbXref "EMAPA:19489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007254 ; owl:annotatedTarget "intervertebral disc of thoracic region" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007255 ; owl:annotatedTarget "An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least one lumbar vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." . [] oboInOwl:hasDbXref "EMAPA:19468" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007255 ; owl:annotatedTarget "intervertebral disc of lumbar region" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007257 ; owl:annotatedTarget "An intervertebral disk that is part of a sacral region of vertebral column. A sacral intervertebral disk connects at least one sacral vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." . [] oboInOwl:hasDbXref "EMAPA:19575" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007257 ; owl:annotatedTarget "intervertebral disc of sacral region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007260 ; owl:annotatedTarget "An intervertebral disk that connects a mammalian cervical vertebra 3 and connects a mammalian cervical vertebra 4." . [] oboInOwl:hasDbXref "FMA:13896" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007260 ; owl:annotatedTarget "C3 intervertebral disk" . _:genid143945 oboInOwl:hasDbXref "FMA:13896" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007260 ; owl:annotatedTarget "intervertebral disk, C3-C4" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004742 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007261 ; owl:annotatedTarget "An intervertebral disk that connects a mammalian cervical vertebra 4 and connects a mammalian cervical vertebra 5." . [] oboInOwl:hasDbXref "FMA:13897" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007261 ; owl:annotatedTarget "intervertebral disc of fourth cervical vertebra" . [] oboInOwl:hasDbXref "FMA:13897" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007261 ; owl:annotatedTarget "intervertebral disk, C4-C5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007262 ; owl:annotatedTarget "An intervertebral disk that connects a mammalian cervical vertebra 5 and connects a mammalian cervical vertebra 6." . [] oboInOwl:hasDbXref "FMA:13898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007262 ; owl:annotatedTarget "intervertebral disc of fifth cervical vertebra" . [] oboInOwl:hasDbXref "FMA:13898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007262 ; owl:annotatedTarget "intervertebral disk, C5-C6" . _:genid143968 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001630, obo:UBERON_0004612 . [] oboInOwl:hasDbXref "GOC:add", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001055 ; owl:annotatedTarget "An intermediate monocyte that is CD14-positive and with low amounts of CD16." . _:genid143970 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "An intervertebral disk that connects a vertebral bone 2 and connects a mammalian cervical vertebra 3." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000327 . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "C2 disk" . _:genid143972 oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "C2 intervertebral disk" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002320 . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "intervertebral disc of cervical vertebra 2" . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "intervertebral disc of second cervical vertebra" . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "intervertebral disk of cervical vertebra 2" . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "intervertebral disk of second cervical vertebra" . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "intervertebral disk, C2-C3" . [] oboInOwl:hasDbXref "FMA:25058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007265 ; owl:annotatedTarget "second cervical intervertebral disk" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007266 ; owl:annotatedTarget "An intervertebral disk that connects a vertebral bone 1 and connects a vertebral bone 2." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007267 ; owl:annotatedTarget _:genid145579 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007267 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a trachea." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007269 ; owl:annotatedTarget "Any collection of muscles that is part of a pectoral appendage." . [] oboInOwl:hasDbXref "ZFA:0000563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007269 ; owl:annotatedTarget "pectoral fin muscle" . [] oboInOwl:hasDbXref "ZFA:0000563" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007269 ; owl:annotatedTarget "pectoral fin musculature" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "sulfurothioate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007270 ; owl:annotatedTarget "Any collection of muscles that is part of a pelvic appendage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000258" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007270 ; owl:annotatedTarget "Musculature that is part of the pelvic fin.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000258" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007270 ; owl:annotatedTarget "pelvic fin musculature" . _:genid144006 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001015 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000026 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006849 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007271 ; owl:annotatedTarget "Any collection of muscles that is part of an appendage." . [] oboInOwl:hasDbXref "ZFA:0000207" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007271 ; owl:annotatedTarget "fin musculature" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007272 ; owl:annotatedTarget _:genid145606 . [] oboInOwl:hasDbXref "VSAO:0005000", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007272 ; owl:annotatedTarget "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." . [] oboInOwl:hasDbXref "VSAO:0005000", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007272 ; owl:annotatedTarget "cheiropterygium" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007273 ; owl:annotatedTarget _:genid145614 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007273 ; owl:annotatedTarget "The collection of all skeletal elements in a pelvic appendage region." . [] oboInOwl:source "XAO-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget _:genid145622 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget _:genid145624 . [] oboInOwl:hasDbXref "Wikipedia:Rhombencephalon" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." . [] oboInOwl:source "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]." . [] oboInOwl:hasDbXref "ZFA:0000569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "presumptive rhombencephalon" . [] oboInOwl:hasDbXref "CALOHA:TS-2118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "embryonic rhombencephalon" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "future hindbrain" . [] oboInOwl:hasDbXref "EHDAA2:0001630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007277 ; owl:annotatedTarget "rhombencephalon" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007278 ; owl:annotatedTarget _:genid145636 . [] oboInOwl:hasDbXref "ZFA:0001722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007278 ; owl:annotatedTarget "Portion of tissue that is part of the heart tube and will become the sinus venosus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007279 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a atrioventricular canal." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002227" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007279 ; owl:annotatedTarget "Portion of tissue that is part of the heart tube and will become the atrioventricular canal.[TAO]" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007280 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a endocardium." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002233" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007280 ; owl:annotatedTarget "Portion of tissue that is part of the heart tube and will become the endocardium.[TAO]" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007281 ; owl:annotatedTarget _:genid145658 . [] oboInOwl:hasDbXref "ZFA:0001187" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007281 ; owl:annotatedTarget "Embryonic structure that gives rise to the midbrain hindbrain boundary." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007281 ; owl:annotatedTarget "presumptive MHB" . [] oboInOwl:hasDbXref "ZFA:0001187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007281 ; owl:annotatedTarget "presumptive midbrain-hindbrain boundary" . ( ) . [] oboInOwl:consistent_with "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; oboInOwl:source "EDHAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007282 ; owl:annotatedTarget _:genid145667 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007282 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a presomitic mesoderm." . [] oboInOwl:hasDbXref "ZFA:0000053" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007282 ; owl:annotatedTarget "presumptive segmental plates" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007284 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a neural plate." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000063" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007284 ; owl:annotatedTarget "Region of the gastrula which gives rise to the neural plate.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007284 ; owl:annotatedTarget "prospective neuroectoderm" . [] oboInOwl:hasDbXref "ZFA:0000063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007284 ; owl:annotatedTarget "prospective vegetal ectoderm" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/1277" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0007285 ; owl:annotatedTarget _:genid145681 . [] oboInOwl:hasDbXref "UBERON:cjm", "https://github.com/obophenotype/uberon/issues/1277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007285 ; owl:annotatedTarget "The part of the blastula that has the potential to develop into a paraxial mesoderm." . _:genid144091 oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007285 ; owl:annotatedTarget "future paraxial mesenchyme" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0006849 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007288 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a forebrain-midbrain boundary." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "thiosulfate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007289 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a rhombomere 1." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007297 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a pronephric mesoderm." . [] oboInOwl:hasDbXref "ZFA:0001070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007297 ; owl:annotatedTarget "nephron primordium" . _:genid144109 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001886 _:genid144111 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 . _:genid144111 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002289, obo:UBERON_0003221 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007299 ; owl:annotatedTarget "A choroid plexus that is part of a cerebral aqueduct." . [] oboInOwl:hasDbXref "ZFA:0001445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007299 ; owl:annotatedTarget "choroid plexus tectal ventricle" . [] oboInOwl:hasDbXref "ZFA:0001445" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007299 ; owl:annotatedTarget "choroid plexus tectal ventricles" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007300 ; owl:annotatedTarget "A blood vessel that is part of a pectoral appendage." . [] oboInOwl:hasDbXref "ZFA:0005301" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007300 ; owl:annotatedTarget "pectoral fin blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007301 ; owl:annotatedTarget "A blood vessel that is part of a limb/fin." . [] oboInOwl:hasDbXref "ZFA:0005299" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007301 ; owl:annotatedTarget "fin blood vessel" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007301 ; owl:annotatedTarget "limb blood vessel" . _:genid144132 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000403, obo:UBERON_0004710 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007302 ; owl:annotatedTarget "A vasculature that is part of a pectoral appendage." . [] oboInOwl:hasDbXref "ZFA:0005096" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007302 ; owl:annotatedTarget "pectoral fin vasculature" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007303 ; owl:annotatedTarget "A vasculature that is part of a chordate pharynx." . [] oboInOwl:hasDbXref "ZFA:0005003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007303 ; owl:annotatedTarget "branchial vasculature" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007304 ; owl:annotatedTarget "A vasculature that is part of a limb/fin." . [] oboInOwl:hasDbXref "ZFA:0005095" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007304 ; owl:annotatedTarget "fin vasculature" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CMP" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007306 ; owl:annotatedTarget _:genid145750 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007306 ; owl:annotatedTarget _:genid145752 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007306 ; owl:annotatedTarget "A glomerular capillary that is part of a pronephros." . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007307 ; owl:annotatedTarget _:genid145759 . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CFU-GEMM" . _:genid144160 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007307 ; owl:annotatedTarget "A glomerular basement membrane that is part of a pronephros." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 . [] oboInOwl:hasDbXref "ZFA:0005313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007307 ; owl:annotatedTarget "pronephric glomerular filtration membrane" . [] oboInOwl:hasDbXref "Wikipedia:Pudendal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007312 ; owl:annotatedTarget "Either the internal or external pudendal arteries." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007312 ; owl:annotatedTarget "EMAPA:37111" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007312 ; owl:annotatedTarget "arteriae pudendae" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007312 ; owl:annotatedTarget "arteriae pudendales" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget _:genid145768 . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "CFU-S" . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "The internal pudendal artery is an artery that branches off the internal iliac artery, providing blood to the external genitalia. The internal pudendal artery is the terminal branch of the anterior trunk of the internal iliac artery. It is smaller in the female than in the male." . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "internal pudendal vessels" . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "arteria pudenda interna" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "arteriae pudendae interna" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "arteriae pudendales interna" . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007315 ; owl:annotatedTarget "internal pudic artery" . [] oboInOwl:hasDbXref "BTO:0001808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007318 ; owl:annotatedTarget "Either of two main superficial veins of the leg, one larger than the other, that begin at the foot." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007318 ; owl:annotatedTarget "EMAPA:37186" . [] oboInOwl:source "ncithesaurus:Saphenous_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007318 ; owl:annotatedTarget "UMLS:C0036186" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007324 ; owl:annotatedTarget "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007324 ; owl:annotatedTarget "EMAPA:37710" . [] oboInOwl:hasDbXref "FMA:16012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007324 ; owl:annotatedTarget "lobulus pancreaticus" . [] oboInOwl:hasDbXref "MA:0000721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007324 ; owl:annotatedTarget "pancreas lobe" . [] oboInOwl:hasDbXref "FMA:16012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007324 ; owl:annotatedTarget "pancreatic lobule" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "multipotential myeloid stem cell" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget obo:UBERON_0003928 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget _:genid145797 . [] oboInOwl:hasDbXref "GOC:cvs", "GOC:ymb", "Wikipedia:Pancreatic_duct", "https://github.com/obophenotype/uberon/issues/1250", "https://orcid.org/0000-0002-2244-7917", "https://orcid.org/0000-0002-6601-2165", "https://orcid.org/0000-0002-9900-7880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "A duct that collects and carries secretions of the exocrine pancreas to the intestine." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000254" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "trioxidosulfidosulfate(2-)" . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "myeloid stem cell" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000254" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "duct of pancreas" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "pancreas duct" . [] oboInOwl:hasDbXref "Wikipedia:Pancreatic_duct" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007329 ; owl:annotatedTarget "ductus pancreaticus" . [] oboInOwl:hasDbXref "Wikipedia:Cartilage_of_pharyngotympanic_tube", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "A triangular plate of elastic fibrocartilage that forms the cartilage component of the pharyngotympanic tube." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_0001059 ; owl:annotatedTarget "pluripotent stem cell (bone marrow)" . [] oboInOwl:hasDbXref "FMA:60096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "cartilage of auditory tube" . [] oboInOwl:hasDbXref "FMA:60096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "cartilage of eustachian tube" . [] oboInOwl:hasDbXref "FMA:60096", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "cartilago tubae auditivae" . [] oboInOwl:hasDbXref "FMA:60096", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "cartilago tubae auditoriae" . [] oboInOwl:hasDbXref "FMA:60096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "pharyngotympanic tube cartilage" . [] oboInOwl:hasDbXref "Wikipedia:Cartilage_of_pharyngotympanic_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007354 ; owl:annotatedTarget "cartilago tubae auditivae; cartilago tubae auditoriae" . [] oboInOwl:hasDbXref "Wikipedia:Bony_part_of_pharyngotympanic_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "The bony part of pharyngotympanic tube is about 12 mm. in length. It begins in the carotid wall of the tympanic cavity, below the septum canalis musculotubarii, and, gradually narrowing, ends at the angle of junction of the squama and the petrous portion of the temporal bone, its extremity presenting a jagged margin which serves for the attachment of the cartilaginous portion." . [] oboInOwl:hasDbXref "FMA:60057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "bony part of auditory tube" . [] oboInOwl:hasDbXref "FMA:60057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "bony part of eustachian tube" . [] oboInOwl:hasDbXref "FMA:60057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "osseous portion of eustachian tube" . [] oboInOwl:hasDbXref "FMA:60057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "pars ossea (tuba auditiva)" . [] oboInOwl:hasDbXref "FMA:60057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "pars ossea (tuba auditoria)" . [] oboInOwl:hasDbXref "Wikipedia:Bony_part_of_pharyngotympanic_tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "osseous portion" . [] oboInOwl:hasDbXref "Wikipedia:Bony_part_of_pharyngotympanic_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007355 ; owl:annotatedTarget "pars ossea tubae auditivae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007367 ; owl:annotatedTarget "An anatomical surface that is part of a tongue." . [] oboInOwl:hasDbXref "FMA:54647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007367 ; owl:annotatedTarget "tongue surface" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007371 ; owl:annotatedTarget "The upper (superior) side of the tongue." . [] oboInOwl:hasDbXref "FMA:54646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007371 ; owl:annotatedTarget "dorsal surface of tongue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007373 ; owl:annotatedTarget "The lower (inferior) side of the tongue." . [] oboInOwl:hasDbXref "FMA:54648" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007373 ; owl:annotatedTarget "ventral surface of tongue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007374 ; owl:annotatedTarget "An incus endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007375 ; owl:annotatedTarget "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones." . _:genid144254 oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007375 ; owl:annotatedTarget "palatum" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010703 . [] oboInOwl:hasDbXref "GO:0008544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007376 ; owl:annotatedTarget "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." . [] oboInOwl:hasDbXref "GO:0008544" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007376 ; owl:annotatedTarget "epidermis" . [] oboInOwl:hasDbXref "BTO:0000313" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007376 ; owl:annotatedTarget "hypoderm" . [] oboInOwl:hasDbXref "GO:0008544", "WBbt:0005733" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007376 ; owl:annotatedTarget "hypodermis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007383 ; owl:annotatedTarget "Outermost layer of cells surrounding the embryo." . _:genid144268 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000086" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007383 ; owl:annotatedTarget "Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000086" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0007383 ; owl:annotatedTarget "relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007383 ; owl:annotatedTarget "EVL" . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-961014-576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007383 ; owl:annotatedTarget "enveloping layer" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007384 ; owl:annotatedTarget "A lymphatic vessel that is part of a limb/fin." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007385 ; owl:annotatedTarget "A lymphatic vessel that is part of a pectoral appendage." . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007386 ; owl:annotatedTarget "A lymphatic vessel that is part of a pelvic appendage." . _:genid144289 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002418 _:genid144291 ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002517 . _:genid144291 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001684, obo:UBERON_0004708 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007389 ; owl:annotatedTarget "A cartilage tissue that is part of a paired limb or fin." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001543" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007389 ; owl:annotatedTarget "Cartilage which is part of one of the paired fins.[TAO]" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "Hyposulfite" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007390 ; owl:annotatedTarget "A cartilage tissue that is part of a pectoral appendage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000257" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007390 ; owl:annotatedTarget "Cartilage which is part of the pectoral fin.[TAO]" . [] oboInOwl:hasDbXref "TAO:0000257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007390 ; owl:annotatedTarget "pectoral fin cartilage" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007391 ; owl:annotatedTarget "A cartilage tissue that is part of a pelvic appendage." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001459" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007391 ; owl:annotatedTarget "Cartilage which is part of the pelvic fin.[TAO]" . [] oboInOwl:hasDbXref "TAO:0001459" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007391 ; owl:annotatedTarget "pelvic fin cartilage" . _:genid144312 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000125 [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001943 ] ) ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000375 . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007414 ; owl:annotatedTarget "A nucleus of brain that spans a midbrain tegmentum." . _:genid144317 oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007414 ; owl:annotatedTarget "tegmental nuclei" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0004657 . [] oboInOwl:hasDbXref "ZFA:0005577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007414 ; owl:annotatedTarget "tegmental nucleus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007416 ; owl:annotatedTarget obo:UBERON_0007417 . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0009976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007416 ; owl:annotatedTarget "Any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem." . [] oboInOwl:source "ncithesaurus:Cerebellar_Peduncle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007416 ; owl:annotatedTarget "UMLS:C0228515" . [] oboInOwl:hasDbXref "EMAPA:35213" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007416 ; owl:annotatedTarget "cerebellum peduncle" . [] oboInOwl:hasDbXref "FMA:83860" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007417 ; owl:annotatedTarget "neuraxis peduncle" . [] oboInOwl:hasDbXref "NLX:144064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007418 ; owl:annotatedTarget "Nerve fibers crossing the midline of the neuraxis relative to their point of origin, on a course to from one level of the nervous system to another. (CUMBO, Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)." . [] oboInOwl:hasDbXref "FMA:83858" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007418 ; owl:annotatedTarget "decussation of neuraxis" . [] oboInOwl:hasDbXref "FMA:83858" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007418 ; owl:annotatedTarget "neuraxis decussation" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007425 ; owl:annotatedTarget obo:UBERON_0007418 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007425 ; owl:annotatedTarget _:genid145938 . _:genid144336 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007425 ; owl:annotatedTarget "A neural decussation that is part of a diencephalon." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000375 . [] oboInOwl:hasDbXref "FMA:62446" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007425 ; owl:annotatedTarget "diencephalon decussation" . _:genid144338 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000464 [ a owl:Restriction ; owl:onProperty obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0007499 ] ) ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001684 . _:genid144342 a owl:Restriction ; owl:onProperty obo:RO_0000086, obo:RO_0002219 ; owl:someValuesFrom obo:PATO_0000608, obo:UBERON_0002364 . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007473 ; owl:annotatedTarget "The space within an epithelial sphere." . [] oboInOwl:hasDbXref "AEO:0000079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007473 ; owl:annotatedTarget "cavity of vesicle" . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007475 ; owl:annotatedTarget "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." . _:genid144355 oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007490 ; owl:annotatedTarget "Acellular anatomical structure whose predominant constituent is keratin." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007223 . [] oboInOwl:hasDbXref "EHDAA2:0003099" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007490 ; owl:annotatedTarget "keratin-based structure" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007499 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "AEO:JB", "UBERONREF:0000001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007499 ; owl:annotatedTarget "An epithelial tube that is open at one end only." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007500 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "AEO:JB", "UBERONREF:0000001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007500 ; owl:annotatedTarget "An epithelial tube open at both ends that allows fluid flow." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007501 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007501 ; owl:annotatedTarget _:genid145970 . [] oboInOwl:hasDbXref "AEO:JB", "UBERONREF:0000001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007501 ; owl:annotatedTarget "A collection of connected epithelial tubes with a single portal." . [] oboInOwl:hasDbXref "AEO:0000117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007501 ; owl:annotatedTarget "arborising epithelial duct system" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007503 ; owl:annotatedTarget obo:UBERON_0000483 . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007503 ; owl:annotatedTarget "A closed epithelium with a lumen." . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007521 ; owl:annotatedTarget "A ring of smooth muscle cells whose contraction closes the opening of the ring." . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007522 ; owl:annotatedTarget "A ring of striated muscle cells whose contraction closes the opening of the ring." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007524 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007524 ; owl:annotatedTarget _:genid145989 . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007524 ; owl:annotatedTarget "Mesenchyme with little extracellular matrix." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007529 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007529 ; owl:annotatedTarget _:genid145993 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007529 ; owl:annotatedTarget _:genid145995 . [] oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007529 ; owl:annotatedTarget "Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix." . _:genid144394 oboInOwl:hasDbXref "AEO:JB" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007530 ; owl:annotatedTarget "Mesenchymal cells that are migrating." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006260 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "S2O3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007567 ; owl:annotatedTarget "An anatomical structure that is undergoing regeneration." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005147" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007567 ; owl:annotatedTarget "A portion of tissue that is regrowing after damage or amputation.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0005147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007567 ; owl:annotatedTarget "regenerating tissue" . [] oboInOwl:hasDbXref "ZFA:0005147" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007567 ; owl:annotatedTarget "regenerating tissues" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget obo:UBERON_0004804 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget obo:UBERON_0007592 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget "A ciliated columnar epithelium that is part of a oviduct." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" . [] oboInOwl:hasDbXref "FMA:62016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget "epithelium of uterine tube" . [] oboInOwl:hasDbXref "FMA:62016" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007589 ; owl:annotatedTarget "uterine tube epithelium" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007590 ; owl:annotatedTarget obo:UBERON_0004804 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007590 ; owl:annotatedTarget "A cuboidal epithelium that is part of a oviduct." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007592 ; owl:annotatedTarget obo:UBERON_0000485 . [] oboInOwl:hasDbXref "FMA:64798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007592 ; owl:annotatedTarget "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]." . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000067 ] ) . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ciliated+epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007601 ; owl:annotatedTarget "Epithelium bearing vibratile cilia on the free surface." . _:genid144431 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007602 ; owl:annotatedTarget obo:UBERON_0000486 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001797 . [] oboInOwl:hasDbXref "Wikipedia:Stratified_columnar_epithelia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007602 ; owl:annotatedTarget "Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP]." . [] oboInOwl:source "ncithesaurus:Stratified_Columnar_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007602 ; owl:annotatedTarget "UMLS:C0836132" . [] oboInOwl:hasDbXref "FMA:45564" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007602 ; owl:annotatedTarget "epithelium stratificatum columnare" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007606 ; owl:annotatedTarget obo:UBERON_0007602 . [] oboInOwl:source "MESH" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007610 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:hasDbXref "MESH:A07.231.114.895" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007610 ; owl:annotatedTarget "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot." . [] oboInOwl:source "ncithesaurus:Tibial_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007610 ; owl:annotatedTarget "UMLS:C0085427" . _:genid144449 oboInOwl:source "BTO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget _:genid146057 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 . [] oboInOwl:hasDbXref "BTO:0001338", "http://www.britannica.com/EBchecked/topic/578563/synovial-tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." . [] oboInOwl:hasDbXref "CALOHA:TS-0998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "synovium" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "stratum synoviale" . [] oboInOwl:hasDbXref "FMA:66762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "synovial layer" . [] oboInOwl:hasDbXref "FMA:66762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "synovial membrane" . [] oboInOwl:hasDbXref "BTO:0001338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007616 ; owl:annotatedTarget "synovial tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a synovial joint." . [] oboInOwl:hasDbXref "FMA:11356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "articular cavity (synovial joint)" . [] oboInOwl:hasDbXref "FMA:11356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "cavitas articularis (junctura synovialis)" . [] oboInOwl:hasDbXref "FMA:11356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "cavity of synovial joint" . [] oboInOwl:hasDbXref "FMA:11356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "joint cavity" . [] oboInOwl:hasDbXref "FMA:11356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007617 ; owl:annotatedTarget "synovial cavity" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007618 ; owl:annotatedTarget _:genid146079 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007618 ; owl:annotatedTarget "A synovial cavity of joint that is part of a hip joint." . [] oboInOwl:source "UBERON" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007619 ; owl:annotatedTarget obo:UBERON_0001781 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007619 ; owl:annotatedTarget "MA does treat internal/external limiting membranes as layers - these are classified as laminae. We do not follow this convention. However, we do following MA is grouping these terms together" . [] oboInOwl:hasDbXref "MA:0001318", "https://github.com/obophenotype/uberon/issues/52" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007619 ; owl:annotatedTarget "retina lamina" . [] oboInOwl:hasDbXref "MP:0005200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007625 ; owl:annotatedTarget "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." . [] oboInOwl:hasDbXref "MESH:A09.371.670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007625 ; owl:annotatedTarget "eye pigment epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007635 ; owl:annotatedTarget "A neural nucleus that is part of a medulla oblongata." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget obo:UBERON_0007245 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget _:genid146098 . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_nerve_nuclei" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget "in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate." . [] oboInOwl:source "BIRNLEX:4096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget "UMLS:C0040999" . [] oboInOwl:hasDbXref "FMA:71248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget "trigeminal nuclei" . [] oboInOwl:hasDbXref "Wikipedia:Trigeminal_nerve_nuclei" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007641 ; owl:annotatedTarget "nuclei trigemini" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Lymph_node#Lymph_nodes_of_the_thorax" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007644 ; owl:annotatedTarget "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "S2O3(2-)" . [] oboInOwl:source "ncithesaurus:Thoracic_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007644 ; owl:annotatedTarget "UMLS:C0229745" . [] oboInOwl:hasDbXref "FMA:12772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007644 ; owl:annotatedTarget "lymph node of thorax" . [] oboInOwl:hasDbXref "FMA:12772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007644 ; owl:annotatedTarget "deep thoracic lymph node" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget _:genid146119 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget _:genid146121 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001060 ; owl:annotatedTarget "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget "A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx." . [] oboInOwl:source "MP:0009726" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget "the outermost mesenchymal covering of the developing brain and spinal cord that is composed of tough fibrous connective tissue from which the arachnoid mater, pia mater and dura mater are formed[MP:0009726]d" . [] oboInOwl:hasDbXref "EHDAA2:0004453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget "primary meninx" . [] oboInOwl:hasDbXref "MP:0009726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007645 ; owl:annotatedTarget "meninx primitiva" . _:genid144514 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0007645 _:genid144516 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000004 . _:genid144516 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000391, obo:UBERON_0003113 . [] oboInOwl:source "ISBN:9781607950325" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007646 ; owl:annotatedTarget _:genid146131 . [] oboInOwl:hasDbXref "ISBN:9781607950325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007646 ; owl:annotatedTarget "The innermost layer of the mesenchymal capsule that surrounds the developing brain, primarily of neural crest origin. The endomeninx forms the leptomeninx." . ( ) . [] oboInOwl:source "ISBN:9781607950325" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007647 ; owl:annotatedTarget _:genid146138 . [] oboInOwl:source "ISBN:9781607950325" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007647 ; owl:annotatedTarget _:genid146140 . [] oboInOwl:hasDbXref "ISBN:9781607950325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007647 ; owl:annotatedTarget "The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer)." . [] oboInOwl:hasDbXref "EHDAA2:0004317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007647 ; owl:annotatedTarget "future dura mater" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007651 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:hasDbXref "http://code.google.com/p/caro2/issues/detail?id=15" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007651 ; owl:annotatedTarget "An anatomical structure that connects two structures." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007652 ; owl:annotatedTarget "A sphincter that is part of an esophagus." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007684 ; owl:annotatedTarget _:genid146152 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007684 ; owl:annotatedTarget "Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." . [] oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0099864", "GO:0072004", "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007687 ; owl:annotatedTarget "Region of the embryo into the area in which the kidney rudiment will develop." . [] oboInOwl:hasDbXref "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007687 ; owl:annotatedTarget "kidney anlage" . [] oboInOwl:source "FBbt" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007688 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "AEO", "FBbt" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007688 ; owl:annotatedTarget obo:UBERON_0005423 . [] oboInOwl:hasDbXref "FBbt:00005426", "http://flybase.org/reports/FBrf0178740.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007688 ; owl:annotatedTarget "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007689 ; owl:annotatedTarget _:genid146168 . [] oboInOwl:hasDbXref "MP:0004662", "Wikipedia:Thyroid_diverticulum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007689 ; owl:annotatedTarget "Endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_diverticulum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007689 ; owl:annotatedTarget "diverticulum thyroideum" . [] oboInOwl:hasDbXref "Wikipedia:Thyroid_diverticulum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007689 ; owl:annotatedTarget "saccus thyroideus" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget _:genid146176 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget _:genid146178 . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001061 ; owl:annotatedTarget "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." . [] oboInOwl:hasDbXref "http://dev.biologists.org/content/128/22/4573.full" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "EHDAA2:0001457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget "early pharyngeal arch endoderm" . [] oboInOwl:hasDbXref "ZFA:0001104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget "pharyngeal endoderm" . [] oboInOwl:hasDbXref "EHDAA2:0001456" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007690 ; owl:annotatedTarget "pharyngeal region endoderm" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget obo:UBERON_0000161 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget _:genid146189 . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?gustatory+pore" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget "The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project." . [] oboInOwl:source "ncithesaurus:Taste_Pore" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget "UMLS:C0226971" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?gustatory+pore" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget "porus gustatorius" . [] oboInOwl:hasDbXref "FMA:63589" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007691 ; owl:annotatedTarget "taste pore" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007692 ; owl:annotatedTarget "A nucleus of brain that is part of a thalamus." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dos", "PMID:15032595", "PMID:16237082", "PMID:26883338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." . [] oboInOwl:hasDbXref "MA:0002992" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007692 ; owl:annotatedTarget "thalamic nucleus" . [] oboInOwl:hasDbXref "FMA:256693" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007692 ; owl:annotatedTarget "nuclear complex of thalamus" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007699 ; owl:annotatedTarget _:genid146207 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007699 ; owl:annotatedTarget "An axon tract that is part of a spinal cord." . [] oboInOwl:source "ncithesaurus:Spinal_Cord_Tract" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007699 ; owl:annotatedTarget "UMLS:C1519456" . [] oboInOwl:hasDbXref "FMA:75683" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007699 ; owl:annotatedTarget "spinal cord tract" . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "TEMRA" . (obo:UBERON_0001018 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000955 ] ) . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007702 ; owl:annotatedTarget _:genid146216 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007702 ; owl:annotatedTarget "An axon tract that is part of a brain." . [] oboInOwl:hasDbXref "FMA:83848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007702 ; owl:annotatedTarget "brain tract" . [] oboInOwl:hasDbXref "DMBA:tracts" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007702 ; owl:annotatedTarget "landmark tracts" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget _:genid146222 . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "TETRATHIONATE" . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "CD8+ TEMRA" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "FMA:72495 most likely denotes this class rather than the more generic parent, due to the part of relationship to pontine tegmentum." . [] oboInOwl:hasDbXref "BIRNLEX:1726", "NIFSTD:NeuroNames_abbrevSource" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "SCPP" . [] oboInOwl:source "BIRNLEX:1726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "neuronames:833" . [] oboInOwl:hasDbXref "BIRNLEX:1726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "SCPP" . [] oboInOwl:hasDbXref "BIRNLEX:1726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "superior cerebellar peduncle of pons" . [] oboInOwl:hasDbXref "NeuroNames:833" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "pedunculus cerebellaris superior (pontis)" . [] oboInOwl:hasDbXref "NeuroNames:833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007709 ; owl:annotatedTarget "superior cerebellar peduncle of the pons" . [] oboInOwl:hasDbXref "PMID:15032595" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0001062 ; owl:annotatedTarget "CD8-positive TEMRA" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/1158" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007719 ; owl:annotatedTarget "A bone that is part of a reproductive organ." . ( ) . _:genid144617 oboInOwl:notes "two in series" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget _:genid146240 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004753 . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_foot" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments." . _:genid144619 oboInOwl:source "ncithesaurus:Interphalangeal_Joint_of_the_Foot" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "UMLS:C0040356" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006290 . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "foot interphalangeal joint" . [] oboInOwl:hasDbXref "EMAPA:36337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "hindlimb digit inter-phalangeal joint" . [] oboInOwl:hasDbXref "FMA:35225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "interphalangeal joint of foot" . [] oboInOwl:hasDbXref "FMA:35225", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "interphalangeal joint of toe" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007721 ; owl:annotatedTarget "toe joint" . [] oboInOwl:notes "two in series" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget _:genid146254 . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes." . [] oboInOwl:source "ncithesaurus:Interphalangeal_Joint_of_the_Hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "UMLS:C0016125" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "articulationes digitorum manus" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "articulationes interphalangeae manus" . [] oboInOwl:hasDbXref "FMA:35285" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "interphalangeal joint of hand" . _:genid144636 oboInOwl:hasDbXref "FMA:35285", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "interphalangeal joint of finger" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009916 . [] oboInOwl:hasDbXref "FMA:35285" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "IP joint" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "articulations of the digits" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "interphalangeal articulations of hand" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007722 ; owl:annotatedTarget "interphalangeal joints of hand" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007723 ; owl:annotatedTarget "An interphalangeal joint of manus that is part of a manual digit 1." . [] oboInOwl:hasDbXref "FMA:35312" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007723 ; owl:annotatedTarget "interphalangeal joint of first digit of hand" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007723 ; owl:annotatedTarget "interphalangeal joint of manual digit I" . [] oboInOwl:hasDbXref "FMA:35312", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007723 ; owl:annotatedTarget "interphalangeal joint of thumb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "An interphalangeal joint of pes that is part of a pedal digit 1." . [] oboInOwl:hasDbXref "FMA:35353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of first digit of foot" . [] oboInOwl:hasDbXref "FMA:35353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of first digit of pes" . [] oboInOwl:hasDbXref "FMA:35353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of great toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of pedal digit I" . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001063 ; owl:annotatedTarget "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." . [] oboInOwl:hasDbXref "FMA:35353", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of big toe" . [] oboInOwl:hasDbXref "FMA:35353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007724 ; owl:annotatedTarget "interphalangeal joint of first toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007725 ; owl:annotatedTarget "An interphalangeal joint of pes that is part of a pedal digit 2." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007725 ; owl:annotatedTarget "interphalangeal joint of pedal digit II" . [] oboInOwl:hasDbXref "FMA:35356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007725 ; owl:annotatedTarget "interphalangeal joint of second digit of foot" . [] oboInOwl:hasDbXref "FMA:35356", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007725 ; owl:annotatedTarget "interphalangeal joint of second toe" . _:genid144676 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007726 ; owl:annotatedTarget "An interphalangeal joint of pes that is part of a pedal digit 3." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006862 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007726 ; owl:annotatedTarget "interphalangeal joint of pedal digit III" . [] oboInOwl:hasDbXref "FMA:35359" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007726 ; owl:annotatedTarget "interphalangeal joint of third digit of foot" . [] oboInOwl:hasDbXref "FMA:35359", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007726 ; owl:annotatedTarget "interphalangeal joint of third toe" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007727 ; owl:annotatedTarget "An interphalangeal joint of pes that is part of a pedal digit 4." . [] oboInOwl:hasDbXref "FMA:35362" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007727 ; owl:annotatedTarget "interphalangeal joint of fourth digit of foot" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007727 ; owl:annotatedTarget "interphalangeal joint of pedal digit IV" . [] oboInOwl:hasDbXref "FMA:35362", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007727 ; owl:annotatedTarget "interphalangeal joint of fourth toe" . (obo:UBERON_0007721 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007728 ; owl:annotatedTarget "An interphalangeal joint of pes that is part of a pedal digit 5." . [] oboInOwl:hasDbXref "FMA:35365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007728 ; owl:annotatedTarget "interphalangeal joint of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:35365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007728 ; owl:annotatedTarget "interphalangeal joint of fifth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007728 ; owl:annotatedTarget "interphalangeal joint of pedal digit V" . [] oboInOwl:hasDbXref "FMA:35365", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007728 ; owl:annotatedTarget "interphalangeal joint of little toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "Thiosulfate" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget _:genid146329 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget "An interphalangeal joint of manus that is part of a manual digit 2." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget "interphalangeal joint of manual digit II" . [] oboInOwl:hasDbXref "FMA:35397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget "interphalangeal joint of second digit of hand" . [] oboInOwl:hasDbXref "FMA:35397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget "interphalangeal joint of second finger" . [] oboInOwl:hasDbXref "FMA:35397", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007729 ; owl:annotatedTarget "interphalangeal joint of index finger" . [] oboInOwl:hasDbXref "GOC:add", "GOC:cg", "GOC:wdd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001064 ; owl:annotatedTarget "A neoplastic cell that is capable of entering a surrounding tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007730 ; owl:annotatedTarget "An interphalangeal joint of manus that is part of a manual digit 3." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007730 ; owl:annotatedTarget "interphalangeal joint of manual digit III" . [] oboInOwl:hasDbXref "FMA:35400" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007730 ; owl:annotatedTarget "interphalangeal joint of third digit of hand" . [] oboInOwl:hasDbXref "FMA:35400" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007730 ; owl:annotatedTarget "interphalangeal joint of third finger" . [] oboInOwl:hasDbXref "FMA:35400", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007730 ; owl:annotatedTarget "interphalangeal joint of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007731 ; owl:annotatedTarget "An interphalangeal joint of manus that is part of a manual digit 4." . [] oboInOwl:hasDbXref "FMA:35403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007731 ; owl:annotatedTarget "interphalangeal joint of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:35403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007731 ; owl:annotatedTarget "interphalangeal joint of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007731 ; owl:annotatedTarget "interphalangeal joint of manual digit IV" . [] oboInOwl:hasDbXref "FMA:35403", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007731 ; owl:annotatedTarget "interphalangeal joint of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007732 ; owl:annotatedTarget "An interphalangeal joint of manus that is part of a manual digit 5." . [] oboInOwl:hasDbXref "FMA:35407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007732 ; owl:annotatedTarget "interphalangeal joint of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:35407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007732 ; owl:annotatedTarget "interphalangeal joint of fifth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007732 ; owl:annotatedTarget "interphalangeal joint of manual digit V" . [] oboInOwl:hasDbXref "FMA:35407", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007732 ; owl:annotatedTarget "interphalangeal joint of little finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget _:genid146373 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 1." . [] oboInOwl:hasDbXref "FMA:35249" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget "metacarpophalangeal joint of first digit of hand" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget "metacarpophalangeal joint of manual digit I" . [] oboInOwl:hasDbXref "EMAPA:25057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget "metacarpo-phalangeal joint of digit 1 of fore-paw" . [] oboInOwl:hasDbXref "FMA:35249", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007735 ; owl:annotatedTarget "metacarpophalangeal joint of thumb" . _:genid144756 a owl:Restriction ; owl:onProperty obo:RO_0002176, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926, obo:UBERON_0004328 . _:genid144758 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget _:genid146386 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003063 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 2." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "metacarpophalangeal joint of manual digit II" . [] oboInOwl:hasDbXref "FMA:35252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "metacarpophalangeal joint of second digit of hand" . [] oboInOwl:hasDbXref "FMA:35252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "metacarpophalangeal joint of second finger" . [] oboInOwl:hasDbXref "EMAPA:25060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "metacarpo-phalangeal joint of digit 2 of fore-paw" . [] oboInOwl:hasDbXref "FMA:35252", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007738 ; owl:annotatedTarget "metacarpophalangeal joint of index finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget _:genid146400 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 3." . _:genid144773 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "metacarpophalangeal joint of manual digit III" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0007827 . [] oboInOwl:hasDbXref "FMA:35255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "metacarpophalangeal joint of third digit of hand" . [] oboInOwl:hasDbXref "FMA:35255" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "metacarpophalangeal joint of third finger" . [] oboInOwl:hasDbXref "NCBITaxon:8782" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "carpometacarpophalangeal joint of third digit" . [] oboInOwl:hasDbXref "EMAPA:25063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "metacarpo-phalangeal joint of digit 3 of fore-paw" . [] oboInOwl:hasDbXref "FMA:35255", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007741 ; owl:annotatedTarget "metacarpophalangeal joint of middle finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget _:genid146415 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 4." . [] oboInOwl:hasDbXref "FMA:35258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "metacarpophalangeal joint of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:35258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "metacarpophalangeal joint of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "metacarpophalangeal joint of manual digit IV" . [] oboInOwl:hasDbXref "NCBITaxon:8782" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "carpometacarpophalangeal joint of fourth digit" . [] oboInOwl:hasDbXref "EMAPA:25066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "metacarpo-phalangeal joint of digit 4 of fore-paw" . [] oboInOwl:hasDbXref "FMA:35258", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007744 ; owl:annotatedTarget "metacarpophalangeal joint of ring finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget _:genid146430 . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "[SO3S](2-)" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 5." . [] oboInOwl:hasDbXref "FMA:35261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "metacarpophalangeal joint of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:35261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "metacarpophalangeal joint of fifth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "metacarpophalangeal joint of manual digit V" . [] oboInOwl:hasDbXref "EMAPA:25069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "metacarpo-phalangeal joint of digit 5 of fore-paw" . [] oboInOwl:hasDbXref "FMA:35261", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007747 ; owl:annotatedTarget "metacarpophalangeal joint of little finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget _:genid146444 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 1." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "the name of the structure in EMAPA is incorrect" . [] oboInOwl:hasDbXref "FMA:35228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "metatarsophalangeal joint of first digit of foot" . [] oboInOwl:hasDbXref "FMA:35228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "metatarsophalangeal joint of great toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "metatarsophalangeal joint of pedal digit I" . [] oboInOwl:hasDbXref "FMA:35228", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "metatarsophalangeal joint of big toe" . [] oboInOwl:hasDbXref "FMA:35228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007750 ; owl:annotatedTarget "metatarsophalangeal joint of first toe" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001065 ; owl:annotatedTarget "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget _:genid146459 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 2." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget "the name of the structure in EMAPA is incorrect" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget "metatarsophalangeal joint of pedal digit II" . [] oboInOwl:hasDbXref "FMA:35231" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget "metatarsophalangeal joint of second digit of foot" . [] oboInOwl:hasDbXref "FMA:35231", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007753 ; owl:annotatedTarget "metatarsophalangeal joint of second toe" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget _:genid146472 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 3." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget "the name of the structure in EMAPA is incorrect" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget "metatarsophalangeal joint of pedal digit III" . [] oboInOwl:hasDbXref "FMA:35234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget "metatarsophalangeal joint of third digit of foot" . [] oboInOwl:hasDbXref "FMA:35234", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007756 ; owl:annotatedTarget "metatarsophalangeal joint of third toe" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget _:genid146485 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 4." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget "the name of the structure in EMAPA is incorrect" . [] oboInOwl:hasDbXref "FMA:35237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget "metatarsophalangeal joint of fourth digit of foot" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget "metatarsophalangeal joint of pedal digit IV" . [] oboInOwl:hasDbXref "FMA:35237", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007759 ; owl:annotatedTarget "metatarsophalangeal joint of fourth toe" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget _:genid146498 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 5." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "the name of the structure in EMAPA is incorrect" . [] oboInOwl:hasDbXref "FMA:35240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "metatarsophalangeal joint of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:35240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "metatarsophalangeal joint of fifth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "metatarsophalangeal joint of pedal digit V" . [] oboInOwl:hasDbXref "FMA:35240", "NCBITaxon:9606" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007762 ; owl:annotatedTarget "metatarsophalangeal joint of little toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007771 ; owl:annotatedTarget "A gland that is part of a epidermis." . [] oboInOwl:hasDbXref "FMA:59153" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007771 ; owl:annotatedTarget "gland of epidermis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007772 ; owl:annotatedTarget "Any portion of sweat that is produced by a sweat gland of the scrotum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007772 ; owl:annotatedTarget "scrotum sweat" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007772 ; owl:annotatedTarget "sweat of scrotal sac" . [] oboInOwl:hasDbXref "FMA:73266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007772 ; owl:annotatedTarget "sweat of scrotum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007773 ; owl:annotatedTarget "Any sweat gland that is part of a scrotum." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget obo:UBERON_0003672 . [] oboInOwl:hasDbXref "MESH:A14.254.237" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "The teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed)." . [] oboInOwl:hasDbXref "FMA:75152", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "dentes permanentes" . [] oboInOwl:hasDbXref "GAID:1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "permanent dentition" . [] oboInOwl:hasDbXref "FMA:75152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "permanent teeth" . [] oboInOwl:hasDbXref "FMA:75152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "set of permanent teeth" . [] oboInOwl:hasDbXref "FMA:75152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "set of secondary teeth" . [] oboInOwl:hasDbXref "GAID:1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "adult dentition" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "thiosulfate ion(2-)" . [] oboInOwl:hasDbXref "GAID:1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007774 ; owl:annotatedTarget "secondary dentition" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007775 ; owl:annotatedTarget "A tooth that forms after a primary tooth." . [] oboInOwl:source "ncithesaurus:Permanent_Tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007775 ; owl:annotatedTarget "UMLS:C0348070" . [] oboInOwl:hasDbXref "FMA:55654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007775 ; owl:annotatedTarget "permanent tooth" . [] oboInOwl:hasDbXref "Wikipedia:Permanent_teeth" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007775 ; owl:annotatedTarget "dentes permanentes" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007778 ; owl:annotatedTarget obo:UBERON_0001986 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007778 ; owl:annotatedTarget _:genid146551 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007778 ; owl:annotatedTarget "An endothelium that is part of a umbilical artery." . ( ) . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/transudate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007779 ; owl:annotatedTarget "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007794 ; owl:annotatedTarget "Any fluid produced by a serous gland." . [] oboInOwl:hasDbXref "Wikipedia:Serous_fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007794 ; owl:annotatedTarget "serosal fluid" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007798 ; owl:annotatedTarget _:genid146569 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007798 ; owl:annotatedTarget "Anatomical system that consists of all blood and lymph vessels." . [] oboInOwl:source "ncithesaurus:Vascular_System" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007798 ; owl:annotatedTarget "The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]." . _:genid144934 oboInOwl:external_ontology "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007798 ; owl:annotatedTarget "in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0004054 . [] oboInOwl:source "ncithesaurus:Vascular_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007798 ; owl:annotatedTarget "UMLS:C0489903" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007806 ; owl:annotatedTarget obo:UBERON_0000478 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007806 ; owl:annotatedTarget _:genid146576 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007806 ; owl:annotatedTarget "A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord." . [] oboInOwl:source "ncithesaurus:Connecting_Stalk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007806 ; owl:annotatedTarget "UMLS:C1516792" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007807 ; owl:annotatedTarget _:genid146584 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007807 ; owl:annotatedTarget "A vasculature that is part of a connecting stalk." . [] oboInOwl:hasDbXref "EHDAA2:0000313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007807 ; owl:annotatedTarget "connecting stalk blood vessels" . [] oboInOwl:hasDbXref "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007808 ; owl:annotatedTarget "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007808 ; owl:annotatedTarget "abdominal adipose tissue" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007808 ; owl:annotatedTarget "abdominal fat" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007808 ; owl:annotatedTarget "intra-abdominal fat" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget obo:UBERON_0000475 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." . [] oboInOwl:source "ncithesaurus:Head_and_Neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "UMLS:C0460004" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/379" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "cephalic area" . [] oboInOwl:hasDbXref "Wikipedia:Head" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "cephalic part of animal" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/379" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "cephalic region" . [] oboInOwl:hasDbXref "FMA:280881" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007811 ; owl:annotatedTarget "head and neck" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton." . _:genid144973 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010338" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "Anatomical structure that is the terminal, flexible posterior appendage of the organism.[AAO]" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0002095 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001117" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "Organism subdivision which is the part of the body posterior to the vent which includes the anal and caudal fins.[TAO]" . [] oboInOwl:source "ncithesaurus:Tail" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "UMLS:C0039259" . [] oboInOwl:hasDbXref "http://purl.oboibrary.org/obo/uberon/tracker/185" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "post-anal fin tail" . [] oboInOwl:hasDbXref "TAO:0001117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007812 ; owl:annotatedTarget "post-vent region" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." . _:genid144984 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000303" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002196 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "EMAPA:37854" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "fin girdle" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "fin girdle region" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "limb girdle" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007823 ; owl:annotatedTarget "limb girdle region" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007826 ; owl:annotatedTarget _:genid146635 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007826 ; owl:annotatedTarget _:genid146637 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007826 ; owl:annotatedTarget "Mesentery that is located in the peritoneum." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "thiosulphate" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007827 ; owl:annotatedTarget "External part of the nose containing the external nares." . [] oboInOwl:source "FMA:59515" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007827 ; owl:annotatedTarget "Subdivision of face, the exterior of the nose, which consists of a root, dorsum, tip, columella, and right and left alae[FMA:59515]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007827 ; owl:annotatedTarget "EMAPA:37831" . [] oboInOwl:source "ncithesaurus:External_Nose" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007827 ; owl:annotatedTarget "UMLS:C0458561" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007828 ; owl:annotatedTarget "A bone that is part of a appendage girdle region." . [] oboInOwl:hasDbXref "MA:0000291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007828 ; owl:annotatedTarget "girdle bone" . _:genid145016 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001421, obo:UBERON_0018674 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007829 ; owl:annotatedTarget obo:UBERON_0007828 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007829 ; owl:annotatedTarget "A bone that is part of a pectoral girdle region." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007830 ; owl:annotatedTarget obo:UBERON_0007828 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007830 ; owl:annotatedTarget "A bone element or fused bone that is part of pelvic girdle." . [] oboInOwl:source "ncithesaurus:Pelvic_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007830 ; owl:annotatedTarget "UMLS:C0030786" . [] oboInOwl:hasDbXref "MA:0000293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007830 ; owl:annotatedTarget "pelvic girdle bone" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget _:genid146679 . [] oboInOwl:hasDbXref "Wikipedia:Pectoral_girdle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000407" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "Anatomical cluster of paired dermal and endochondral bones that attaches to the dorso-posterior part of the cranium, and support the radials and pectoral fin. It consists of two components: the primary pectoral girdle consisting of the endochondral coracoid, scapula and mesocoracoid bones, and the secondary pectoral girdle consisting of the dermal posttemporal, supracleithrum, cleithrum and poscleithrum(thra) bones.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000156" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "Girdle skeleton consisting of a set of bones linking the axial series to the forelimb/fin skeleton and offering anchoring areas for forelimb/fin and caudal musculature.[VSAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000422" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "Skeletal structure immediately behind the head attached to the vertebral column by muscles and supporting the forelimbs.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001156" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.336 and Figure 9.18", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "The pectoral girdle is clearly of dual origin, composed of dermal as well as endochondral bones. The endochondral component, the scapulocoracoid, evolved by fusion or enlargment of several basal fin elements. (...) The dermal component of the shoulder girdle evolved from dermal bones of the body's surface. (...) Like endochondral bones, these dermal bones were passed along to tetrapods (...).[well established][VHOG]" . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "Note that the VSAO and many ontologies use the label 'pectoral girdle' to denote the skeletal region specifically." . [] oboInOwl:source "ncithesaurus:Shoulder_Girdle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "UMLS:C0427245" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "skeletal parts of pectoral girdle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "skeleton of pectoral girdle" . [] oboInOwl:hasDbXref "Wikipedia:Pectoral_girdle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "cingulum pectorale" . [] oboInOwl:hasDbXref "VSAO:0000156" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "pectoral girdle" . [] oboInOwl:hasDbXref "TAO:0000407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007831 ; owl:annotatedTarget "scapular girdle" . [] oboInOwl:source "PMID:21455939" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget _:genid146701 . [] oboInOwl:hasDbXref "VSAO:0000155", "Wikipedia:Pelvis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000426" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "Anatomical cluster by which the hind limbs are supported and attached to the vertebral column.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000565" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "Anatomical cluster that consists of the paired basipterygia which support the pelvic fin.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000155" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "Girdle skeleton consisting of a set of bones linking the axial series to the hindlimb/fin skeleton and offering anchoring areas for hindlimb/fin and caudal musculature.[VSAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000305" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.333", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "Note that the VSAO and many ontologies use the label 'pelvic girdle' to denote the skeletal region specifically. We place the EHDAA2 class here, note that this includes the pre-cartilage condensation as parts" . [] oboInOwl:hasDbXref "VSAO:0000155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "pelvic girdle skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "skeletal parts of pelvic girdle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "skeleton of pelvic girdle" . [] oboInOwl:hasDbXref "VSAO:0000155" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007832 ; owl:annotatedTarget "pelvic girdle" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007842 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000023", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007842 ; owl:annotatedTarget "Bone element that arises as a result of intramembranous ossification." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000023" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007842 ; owl:annotatedTarget "Bone element that arises as a result of intramembranous ossification.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001645" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007842 ; owl:annotatedTarget "Intramembranous bone that forms deep in the organism.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0001636" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007842 ; owl:annotatedTarget "membrane bones" . _:genid145076 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418, obo:UBERON_0003852 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget obo:UBERON_0004765 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget _:genid146724 . _:genid145080 oboInOwl:source "VSAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget _:genid146726 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003852 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000000", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "Skeletal element that is composed of cartilage tissue and may be permanent or transient." . [] oboInOwl:external_ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "TAO still mixes tissue and element" . [] oboInOwl:hasDbXref "FMA:55107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "cartilage organ" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "cartilaginous element" . [] oboInOwl:hasDbXref "VSAO:0000000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "chondrogenic element" . [] oboInOwl:hasDbXref "VSAO:0000000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0007844 ; owl:annotatedTarget "cartilage" . _:genid145089 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002215 ; owl:someValuesFrom obo:GO_0008015, obo:UBERON_0011860 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007845 ; owl:annotatedTarget obo:UBERON_0002384 . [] oboInOwl:hasDbXref "FMA:20103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007845 ; owl:annotatedTarget "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget obo:UBERON_0007845 . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget obo:UBERON_0011823 . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16094 ; owl:annotatedTarget "trioxido-1kappa(3)O-disulfate(S--S)(2-)" . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000050", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000050" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO]" . [] oboInOwl:date_retrieved "2012-08-29" ; oboInOwl:external_class "FMA:64781" ; oboInOwl:ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA]" . [] oboInOwl:source "ncithesaurus:Regular_Dense_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "UMLS:C0225333" . [] oboInOwl:hasDbXref "FMA:64781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "dense fibrous connective tissue" . [] oboInOwl:hasDbXref "FMA:64781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "dense regular collagenous connective tissue" . [] oboInOwl:hasDbXref "FMA:64781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "dense regular collagenous tissue" . [] oboInOwl:hasDbXref "FMA:64781" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007846 ; owl:annotatedTarget "typus regularis (textus connectivus collagenosus compactus)" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001066 ; owl:annotatedTarget "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007914 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007914 ; owl:annotatedTarget _:genid146760 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007914 ; owl:annotatedTarget "A bone that is part of a craniocervical region." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0007914 ; owl:annotatedTarget "EMAPA:37245" . [] oboInOwl:hasDbXref "MA:0000569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007914 ; owl:annotatedTarget "head or neck bone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0007997 ; owl:annotatedTarget obo:UBERON_0001479 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0007997 ; owl:annotatedTarget "A sesamoid bone that is part of a manus." . [] oboInOwl:hasDbXref "FMA:42353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0007997 ; owl:annotatedTarget "sesamoid bone of hand" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008000 ; owl:annotatedTarget obo:UBERON_0001479 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008000 ; owl:annotatedTarget _:genid146778 . _:genid145131 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008000 ; owl:annotatedTarget "A sesamoid bone that is part of a pes." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0006844 . [] oboInOwl:hasDbXref "FMA:45096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008000 ; owl:annotatedTarget "sesamoid bone of foot" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008001 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:hasDbXref "Wikipedia:Irregular_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008001 ; owl:annotatedTarget "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." . [] oboInOwl:source "ncithesaurus:Irregular_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008001 ; owl:annotatedTarget "UMLS:C0502414" . [] oboInOwl:hasDbXref "Wikipedia:Irregular_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008001 ; owl:annotatedTarget "os irregulare" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008114 ; owl:annotatedTarget obo:UBERON_0000982 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008114 ; owl:annotatedTarget "A skeletal joint that is part of a appendage girdle region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008114 ; owl:annotatedTarget "girdle joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008115 ; owl:annotatedTarget "An anatomical surface that is part of a cartilage element." . [] oboInOwl:hasDbXref "FMA:76668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008115 ; owl:annotatedTarget "cartilage surface" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008188 ; owl:annotatedTarget obo:UBERON_0000043 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008188 ; owl:annotatedTarget "A tendon that attaches_to a biceps brachii." . [] oboInOwl:hasDbXref "FMA:38152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008188 ; owl:annotatedTarget "biceps brachii tendon" . [] oboInOwl:hasDbXref "FMA:38152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008188 ; owl:annotatedTarget "tendon of biceps brachii muscle" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dsd", "PMID:23348417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001067 ; owl:annotatedTarget "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008192 ; owl:annotatedTarget obo:UBERON_0000043 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008192 ; owl:annotatedTarget "A tendon that attaches_to a triceps brachii." . [] oboInOwl:hasDbXref "FMA:38380" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008192 ; owl:annotatedTarget "triceps brachii tendon" . [] oboInOwl:hasDbXref "FMA:38380" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008192 ; owl:annotatedTarget "tendon of triceps brachii muscle" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=11303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008193 ; owl:annotatedTarget "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." . [] oboInOwl:hasDbXref "FMA:7478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008193 ; owl:annotatedTarget "os pneumaticum" . [] oboInOwl:hasDbXref "FMA:7478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008193 ; owl:annotatedTarget "pneumatic bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008196 ; owl:annotatedTarget "Any muscle organ that is part of a pectoral girdle region." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008196 ; owl:annotatedTarget "EMAPA has both non-skeletal and skeletal types, with the non-skeletal also including a chest muscle, so we place the skeletal class here as the most accurate" . [] oboInOwl:hasDbXref "FMA:37347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008196 ; owl:annotatedTarget "muscle of shoulder girdle" . [] oboInOwl:hasDbXref "FMA:37347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008196 ; owl:annotatedTarget "pectoral girdle muscle" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008198 ; owl:annotatedTarget _:genid146833 . [] oboInOwl:hasDbXref "Wikipedia:Nail_plate", "https://github.com/obophenotype/uberon/issues/20", "https://sourceforge.net/p/geneontology/ontology-requests/8479/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008198 ; owl:annotatedTarget "The nail plate is the hard and translucent portion of the nail, composed of keratin." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008198 ; owl:annotatedTarget "in FMA, the nail is the nail plate" . [] oboInOwl:hasDbXref "Wikipedia:Nail_plate" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008198 ; owl:annotatedTarget "lamina unguis" . [] oboInOwl:source "MESH" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget _:genid146839 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget _:genid146841 . [] oboInOwl:hasDbXref "TAO:0002254", "Wikipedia:Chin" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "A subdivision of the face that is the anteriormost part of the lower jaw region." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002254" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "Surface structure that is the anteriormost region of the lower jaw.[TAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "EMAPA:37827" . [] oboInOwl:hasDbXref "FMA:46495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "mental part of face" . [] oboInOwl:hasDbXref "FMA:46495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "mental region" . [] oboInOwl:hasDbXref "FMA:46495" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "mental region of face" . [] oboInOwl:hasDbXref "FMA:46495", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "regio mentalis" . [] oboInOwl:hasDbXref "Wikipedia:Chin" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008199 ; owl:annotatedTarget "mentum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget _:genid146851 . [] oboInOwl:hasDbXref "MESH:A01.456.505.580", "Wikipedia:Forehead" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget "The part of the face above the eyes[MESH]. In human anatomy, the forehead is the fore part of the head. It is, formally, an area of the head bounded by three features, two of the skull and one of the scalp. The top of the forehead is marked by the hairline, the edge of the area where hair on the scalp grows. The bottom of the forehead is marked by the supraorbital ridge, the bone feature of the skull above the eyes. The two sides of the forehead are marked by the temporal ridge, a bone feature that links the supraorbital ridge to the coronal suture line and beyond[WP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget "EMAPA:37869" . [] oboInOwl:source "ncithesaurus:Forehead" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget "UMLS:C0016540" . [] oboInOwl:hasDbXref "Wikipedia:Forehead" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget "fore head" . [] oboInOwl:hasDbXref "Wikipedia:Forehead" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008200 ; owl:annotatedTarget "sinciput" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008202 ; owl:annotatedTarget _:genid146858 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008202 ; owl:annotatedTarget "in MA, this includes the femur. i.e. pelvic girdle bone or femur; note that this makes the ilium etc in MA hindlimb bones. in MA this is a hindlimb bone" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008202 ; owl:annotatedTarget "EMAPA:37308" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001082 ; owl:annotatedTarget "An innate lyphoid cell with an immature phenotype." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008203 ; owl:annotatedTarget "The part of the ventral body cavity that is within the pelvis." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008203 ; owl:annotatedTarget "EMAPA:37235" . [] oboInOwl:hasDbXref "FMA:9738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008203 ; owl:annotatedTarget "space of pelvic compartment" . [] oboInOwl:hasDbXref "Wikipedia:Pelvic_cavity" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008203 ; owl:annotatedTarget "cavitas pelvis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001201 ; owl:annotatedTarget "A B cell that is CD19-positive." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget obo:UBERON_0001015 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget _:genid146878 . [] oboInOwl:hasDbXref "ZFA:0000328", "ZFA:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "Musculature system of the pharyngeal and head regions." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "in MA this is restricted to skeletal muscles" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "EMAPA:37259" . [] oboInOwl:hasDbXref "MA:0000571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "head or neck muscle" . [] oboInOwl:hasDbXref "ZFA:0000328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "head muscles" . [] oboInOwl:hasDbXref "MA:0000571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008229 ; owl:annotatedTarget "head or neck muscle" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008230 ; owl:annotatedTarget obo:UBERON_0000366 . [] oboInOwl:hasDbXref "Fast_Health_Medical_Dictionary:http://www.fasthealth.com/dictionary/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008230 ; owl:annotatedTarget "Either of two muscles of the calf of the leg." . [] oboInOwl:source "ncithesaurus:Tibialis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008230 ; owl:annotatedTarget "UMLS:C1710422" . [] oboInOwl:hasDbXref "MA:0002425" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008230 ; owl:annotatedTarget "tibialis muscle" . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget _:genid146891 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget _:genid146893 . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "EMAPA:37234" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001203 ; owl:annotatedTarget obo:CL_0000909 . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "dorsum of thorax" . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "posterior part of thorax" . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "thoracic back" . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "thoracic part of back" . [] oboInOwl:hasDbXref "MA:0000028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "upper back" . [] oboInOwl:hasDbXref "FMA:24217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008231 ; owl:annotatedTarget "back of thorax" . [] oboInOwl:hasDbXref "GOC:tfm", "GO_REF:0000031", "PMID:20146720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001203 ; owl:annotatedTarget "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008242 ; owl:annotatedTarget obo:UBERON_0003833 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008242 ; owl:annotatedTarget _:genid146908 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008242 ; owl:annotatedTarget "A muscle of back that is part of a lower back." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008242 ; owl:annotatedTarget "EMAPA:37262" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008243 ; owl:annotatedTarget obo:UBERON_0003830 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008243 ; owl:annotatedTarget _:genid146917 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008243 ; owl:annotatedTarget "A muscle of back that is part of a dorsal thoracic segment of trunk." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008243 ; owl:annotatedTarget "EMAPA:37261" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008255 ; owl:annotatedTarget obo:UBERON_0001105 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008255 ; owl:annotatedTarget "A clavicle that is in the right side of a entire appendicular skeleton." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0001204 ; owl:annotatedTarget obo:CL_0000897 . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008256 ; owl:annotatedTarget obo:UBERON_0001105 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008256 ; owl:annotatedTarget "A clavicle that is in the left side of a entire appendicular skeleton." . [] oboInOwl:source "FMA-moved" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget obo:UBERON_0008846 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget _:genid146938 . [] oboInOwl:hasDbXref "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0001204 ; owl:annotatedTarget "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." . [] oboInOwl:is_entailed "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget _:genid146940 . [] oboInOwl:source "PMID:19767574", "Wikipedia:Dental_follicle" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget _:genid146942 . [] oboInOwl:hasDbXref "BTO:0001020", "Wikipedia:Periodontal_fiber", "https://github.com/obophenotype/uberon/issues/1233", "https://github.com/obophenotype/uberon/issues/21" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]." . [] oboInOwl:source "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "The collagen fibers, running from the cementum to the alveolar bone, that suspend a tooth in its socket; they include apical, oblique, horizontal, and alveolar crest fibers, indicating that the orientation of the fibers varies at different levels[http://www.drugs.com/dict/desmodentium.html]." . [] oboInOwl:source "Wikipedia:Periodontal_fiber" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. It consist of cells, extracellular compartment of fibers. The cells are fibroblast, epithelial, undifferentiated mesenchymal cells, bone and cementum cells. The extracellular compartment consists of collagen fibers bundles embedded in ground substance. The PDL substance has been estimated to be 70% water and is thought to have a significant effect on the tooth's ability to withstand stress loads[WP][BTO:0001020, Wikipedia:Periodontal_fiber, https://github.com/obophenotype/uberon/issues/21]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "FMA treats periodontium and periodontal ligament as the same; it has a separate class desmodentium, which we place here even though it is classified as fetal in FMA" . [] oboInOwl:hasDbXref "Wikipedia:Periodontal_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "fibra periodontalis" . [] oboInOwl:hasDbXref "Wikipedia:Periodontal_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "periodontal fiber" . [] oboInOwl:hasDbXref "Wikipedia:Periodontal_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "periodontal fibre" . [] oboInOwl:hasDbXref "Wikipedia:Periodontal_ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "PDL" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "alveolar periosteum" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "alveolodental ligament" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "alveolodental membrane" . [] oboInOwl:hasDbXref "BTO:0001020", "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "desmodontium" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "odontoperiosteum" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "paradentium" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridental membrane" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontal fiber" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontal fibre" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontal ligament fiber" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/desmodentium.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontal ligament fibre" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontal membrane" . [] oboInOwl:hasDbXref "BTO:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "peridontium" . [] oboInOwl:hasDbXref "FMA:56665" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008266 ; owl:annotatedTarget "periodontium" . [] oboInOwl:hasDbXref "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/tooth+germ" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008281 ; owl:annotatedTarget "A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them." . [] oboInOwl:source "ncithesaurus:Tooth_Bud" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008281 ; owl:annotatedTarget "UMLS:C0040442" . [] oboInOwl:hasDbXref "FMA:306006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008281 ; owl:annotatedTarget "dental bud" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/tooth+germ" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008281 ; owl:annotatedTarget "dental germ" . [] oboInOwl:hasDbXref "Wikipedia:Tooth_development" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008281 ; owl:annotatedTarget "tooth germ" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008307 ; owl:annotatedTarget "An endothelium that is part of a heart [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0004293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008307 ; owl:annotatedTarget "cardiac endothelium" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008310 ; owl:annotatedTarget "A gland that is part of a nasopharynx." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008320 ; owl:annotatedTarget obo:UBERON_0004573 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008320 ; owl:annotatedTarget _:genid146984 . [] oboInOwl:hasDbXref "Wikipedia:Penile_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008320 ; owl:annotatedTarget "The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery." . [] oboInOwl:hasDbXref "FMA:66318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008320 ; owl:annotatedTarget "artery of penis" . [] oboInOwl:hasDbXref "BTO:0005085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008320 ; owl:annotatedTarget "penile artery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget _:genid146997 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget _:genid146999 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget _:genid147001 . [] oboInOwl:hasDbXref "Wikipedia:Deep_artery_of_the_penis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "The deep artery of the penis (artery to the corpus cavernosum), one of the terminal branches of the internal pudendal, arises from that vessel while it is situated between the two fascia of the urogenital diaphragm (deep perineal pouch). It pierces the inferior fascia, and, entering the crus penis obliquely, runs forward in the center of the corpus cavernosum penis, to which its branches are distributed." . [] oboInOwl:hasDbXref "BTO:0005086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "arteria profunda penis" . [] oboInOwl:hasDbXref "FMA:19794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "deep penile artery" . [] oboInOwl:hasDbXref "BTO:0005086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "arteria cavernosa penis" . [] oboInOwl:hasDbXref "Wikipedia:Deep_artery_of_the_penis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "arteria profunda penis" . [] oboInOwl:hasDbXref "BTO:0005086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008321 ; owl:annotatedTarget "cavernosal artery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008322 ; owl:annotatedTarget _:genid147015 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008322 ; owl:annotatedTarget _:genid147017 . [] oboInOwl:hasDbXref "Wikipedia:Deep_artery_of_clitoris" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008322 ; owl:annotatedTarget "The deep artery of clitoris is a branch of the internal pudendal artery." . [] oboInOwl:hasDbXref "Wikipedia:Deep_artery_of_clitoris" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008322 ; owl:annotatedTarget "arteria profunda clitoridis" . [] oboInOwl:hasDbXref "Wikipedia:Erectile_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008324 ; owl:annotatedTarget "With numerous vascular spaces that may become engorged with blood." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008331 ; owl:annotatedTarget "A smooth muscle tissue that is part of a clitoris." . [] oboInOwl:hasDbXref "BTO:0005000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008331 ; owl:annotatedTarget "clitoris smooth muscle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget obo:UBERON_0005445 . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "The sole is the bottom of the foot." . [] oboInOwl:source "ncithesaurus:Plantar_Region" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "UMLS:C0230463" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "planta" . [] oboInOwl:hasDbXref "FMA:25000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "plantar part of foot" . [] oboInOwl:hasDbXref "FMA:25000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "plantar region" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "regio plantaris" . [] oboInOwl:hasDbXref "FMA:25000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "sole" . [] oboInOwl:hasDbXref "FMA:25000" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "sole of foot" . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "pelma" . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "planta" . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "sole of foot" . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "sole of the foot" . [] oboInOwl:hasDbXref "Wikipedia:Sole_(foot)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008338 ; owl:annotatedTarget "soles of the feet" . _:genid145380 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0007592, obo:UBERON_8410081 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008339 ; owl:annotatedTarget obo:UBERON_0004852 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008340 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008340 ; owl:annotatedTarget _:genid147054 . [] oboInOwl:hasDbXref "DOI:10.1002/ajmg.a.32600", "Wikipedia:Nasal_bridge" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008340 ; owl:annotatedTarget "A saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canth[WP]." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008341 ; owl:annotatedTarget _:genid147057 . [] oboInOwl:hasDbXref "DOI:10.1002/ajmg.a.32600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008341 ; owl:annotatedTarget "The tissue that links the nasal tip to the nasal base, and separates the nares. It is the inferior margin of the nasal septum[EoM]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008341 ; owl:annotatedTarget "EMAPA:37832" . [] oboInOwl:hasDbXref "FMA:59725" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008341 ; owl:annotatedTarget "columella" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008342 ; owl:annotatedTarget "An intestinal villus in the duodenum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008343 ; owl:annotatedTarget "An intestinal villus in the jejunum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008344 ; owl:annotatedTarget "An intestinal villus in the ileum." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008345 ; owl:annotatedTarget _:genid147084 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008345 ; owl:annotatedTarget "An epithelium that is part of a ileum." . [] oboInOwl:hasDbXref "FMA:17233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008345 ; owl:annotatedTarget "epithelium of ileum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008346 ; owl:annotatedTarget _:genid147092 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008346 ; owl:annotatedTarget "An epithelium that is part of a duodenum." . [] oboInOwl:hasDbXref "FMA:17231" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008346 ; owl:annotatedTarget "epithelium of duodenum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008367 ; owl:annotatedTarget "An epithelium that is part of a breast." . ( ) . [] oboInOwl:hasDbXref "Dorlands_Medical_Dictionary:MerckMedicus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008397 ; owl:annotatedTarget "Epithelium pertaining to the trachea and bronchi." . [] oboInOwl:hasDbXref "BTO:0002925" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008397 ; owl:annotatedTarget "bronchotracheal epithelium" . _:genid145439 oboInOwl:source "BTO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008420 ; owl:annotatedTarget _:genid147111 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004362 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008420 ; owl:annotatedTarget "An epithelium that is part of a buccal mucosa." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008425 ; owl:annotatedTarget "A ridge of epidermal cells that will form the mammary placodes." . [] oboInOwl:hasDbXref "http://dictionary.reference.com/browse/mammary+ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008425 ; owl:annotatedTarget "mammary fold" . [] oboInOwl:hasDbXref "EMAPA:18541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008425 ; owl:annotatedTarget "mammary gland ridge" . [] oboInOwl:hasDbXref "Wikipedia:Milk_line" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008425 ; owl:annotatedTarget "mammary line" . [] oboInOwl:hasDbXref "Wikipedia:Milk_line" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008425 ; owl:annotatedTarget "milk line" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008429 ; owl:annotatedTarget "A vertebral foramen that is part of a cervical vertebra." . (obo:UBERON_0001131 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002414 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008430 ; owl:annotatedTarget "A vertebral foramen that is part of a lumbar vertebra." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008431 ; owl:annotatedTarget "A vertebral foramen that is part of a sacral vertebra." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008432 ; owl:annotatedTarget "A vertebral foramen that is part of a thoracic vertebra." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008433 ; owl:annotatedTarget "A neural arch that is part of a lumbar vertebra." . [] oboInOwl:hasDbXref "FMA:16076" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008433 ; owl:annotatedTarget "arch of lumbar vertebra" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002000 ; owl:annotatedTarget obo:CL_0001066 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008434 ; owl:annotatedTarget "A neural arch that is part of a cervical vertebra." . [] oboInOwl:hasDbXref "FMA:23893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008434 ; owl:annotatedTarget "arch of cervical vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008435 ; owl:annotatedTarget "A neural arch that is part of a sacral vertebra." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002000 ; owl:annotatedTarget "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008436 ; owl:annotatedTarget "A neural arch that is part of a thoracic vertebra." . [] oboInOwl:hasDbXref "FMA:9151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008436 ; owl:annotatedTarget "arch of thoracic vertebra" . (obo:UBERON_0000982 [ a owl:Restriction ; owl:onClass obo:UBERON_0001447 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:notes "two adjacent tarsals" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget _:genid147172 . [] oboInOwl:hasDbXref "Wikipedia:Intertarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "EMAPA:37762" . [] oboInOwl:source "ncithesaurus:Tarsal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "UMLS:C1527245" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "articulationes intertarsale" . [] oboInOwl:hasDbXref "Wikipedia:Intertarsal_articulations" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "articulationes intertarsales" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "articulationes intertarseae" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "intermetatarsal joint" . [] oboInOwl:hasDbXref "Wikipedia:Intertarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "intertarsal" . [] oboInOwl:hasDbXref "Wikipedia:Intertarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "intertarsal articulation" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "intertarsal joint" . [] oboInOwl:hasDbXref "MESH:A02.835.583.378.831" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "tarsal joint" . [] oboInOwl:hasDbXref "Wikipedia:Intertarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008447 ; owl:annotatedTarget "tarsal joints" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008456 ; owl:annotatedTarget "A prezygapophysis that is part of a lumbar vertebra." . [] oboInOwl:hasDbXref "FMA:16126" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008456 ; owl:annotatedTarget "cranial articular process of lumbar vertebra" . [] oboInOwl:hasDbXref "FMA:16126" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008456 ; owl:annotatedTarget "superior articular process of lumbar vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "A prezygapophysis that is part of a sacral vertebra." . [] oboInOwl:hasDbXref "FMA:16215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "articular process of sacral segment" . [] oboInOwl:hasDbXref "FMA:16215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "processus articularis superior (os sacrum)" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "processus articularis superior ossis sacri" . [] oboInOwl:hasDbXref "FMA:16215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "superior articular process of sacral segment" . [] oboInOwl:hasDbXref "FMA:16215" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "superior articular process of sacral vertebra" . [] oboInOwl:hasDbXref "FMA:16215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008457 ; owl:annotatedTarget "superior articular process of sacrum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008459 ; owl:annotatedTarget "A prezygapophysis that is part of a cervical vertebra." . [] oboInOwl:hasDbXref "FMA:23969" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008459 ; owl:annotatedTarget "superior articular process of cervical vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "A prezygapophysis that is part of a thoracic vertebra." . [] oboInOwl:hasDbXref "FMA:9155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "cranial articular process of thoracic vertebra" . [] oboInOwl:hasDbXref "FMA:9155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "processus articularis (zygapophysis) thoracicus superior" . [] oboInOwl:hasDbXref "FMA:9155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "superior apophyseal process" . [] oboInOwl:hasDbXref "FMA:9155" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "superior articular process of thoracic vertebra" . [] oboInOwl:hasDbXref "FMA:9155" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008460 ; owl:annotatedTarget "superior zygapophysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008461 ; owl:annotatedTarget "An postzygapophysis that is part of a lumbar vertebra." . [] oboInOwl:hasDbXref "FMA:16127" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008461 ; owl:annotatedTarget "caudal articular process of lumbar vertebra" . [] oboInOwl:hasDbXref "FMA:16127" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008461 ; owl:annotatedTarget "inferior articular process of lumbar vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008462 ; owl:annotatedTarget "An postzygapophysis that is part of a cervical vertebra." . [] oboInOwl:hasDbXref "FMA:23970" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008462 ; owl:annotatedTarget "inferior articular process of cervical vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "An postzygapophysis that is part of a thoracic vertebra." . [] oboInOwl:hasDbXref "FMA:9156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "caudal articular process of thoracic vertebra" . [] oboInOwl:hasDbXref "FMA:9156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "inferior apophyseal process" . [] oboInOwl:hasDbXref "FMA:9156" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "inferior articular process of thoracic vertebra" . [] oboInOwl:hasDbXref "FMA:9156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "inferior zygapophysis" . [] oboInOwl:hasDbXref "FMA:9156" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008463 ; owl:annotatedTarget "processus articularis (zygapophysis) thoracicus inferior" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008522 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008522 ; owl:annotatedTarget "Any muscle organ that is part of an nose." . [] oboInOwl:source "ncithesaurus:Nasal_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008522 ; owl:annotatedTarget "UMLS:C0224219" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008522 ; owl:annotatedTarget "muscle of nose" . _:genid145579 a owl:Restriction ; owl:onProperty obo:BSPO_0000099, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001685, obo:UBERON_0009505 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget _:genid147255 . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "The infrahyoid muscles are a group of four pairs of muscles in the anterior part of the neck. (The term infrahyoid refers to the region below to the hyoid bone in the neck. ) Collectively, they are referred to as the strap muscles, because the muscles are long and flat much like a strap." . [] oboInOwl:hasDbXref "FMA:13338", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "musculus infrahyoideus" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "infrahyoid" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "infrahyoid muscle" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "infrahyoidala" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "musculi infrahyoidei" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "strap muscle" . [] oboInOwl:hasDbXref "Wikipedia:Infrahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008523 ; owl:annotatedTarget "strap muscles" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002001 ; owl:annotatedTarget obo:CL_0000557 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget obo:UBERON_0002000 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget _:genid147266 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget _:genid147268 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget _:genid147270 . [] oboInOwl:hasDbXref "Wikipedia:Piriformis_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "The piriformis is a muscle in the gluteal region that originates from the anterior (front) part of the sacrum, the part of the spine in the gluteal region, and from the superior margin of the greater sciatic notch (as well as the sacroiliac joint capsule and the sacrotuberous ligament). It exits the pelvis through the greater sciatic foramen to insert on the greater trochanter of the femur. Its tendon often joins with the tendons of the superior gemellus, inferior gemellus, and obturator internus muscles prior to insertion[WP,modified]." . [] oboInOwl:hasDbXref "FMA:19082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "m.piriformis" . [] oboInOwl:hasDbXref "FMA:19082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "piriformis" . [] oboInOwl:hasDbXref "Wikipedia:Piriformis_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "musculus piriformis" . [] oboInOwl:hasDbXref "Wikipedia:Piriformis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "piriform muscle" . [] oboInOwl:hasDbXref "Wikipedia:Piriformis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008529 ; owl:annotatedTarget "piriformis muscle" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Beilstein:2060565" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002001 ; owl:annotatedTarget "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." . [] oboInOwl:hasDbXref "Wikipedia:Suprahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008571 ; owl:annotatedTarget "A muscle in the region above the hyoid bone in the neck. The suprahyoid muscles include digastric, stylohyoid, geniohyoid, and mylohyoid." . [] oboInOwl:hasDbXref "Wikipedia:Suprahyoid_muscles" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008571 ; owl:annotatedTarget "musculi suprahyoidei" . _:genid145606 oboInOwl:hasDbXref "Wikipedia:Suprahyoid_muscles" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008571 ; owl:annotatedTarget "suprahyoid" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004710 . [] oboInOwl:hasDbXref "Wikipedia:Suprahyoid_muscles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008571 ; owl:annotatedTarget "suprahyoidala" . [] oboInOwl:notes "recurrent laryngeal branch of the vagus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget _:genid147286 . [] oboInOwl:notes "posterior part of the cricoid" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget _:genid147288 . [] oboInOwl:notes "muscular process of the arytenoid cartilage" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget _:genid147290 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget _:genid147292 . [] oboInOwl:hasDbXref "Wikipedia:Posterior_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "The posterior cricoarytenoid muscles are extremely small, paired muscles that extend from the posterior cricoid cartilage to the arytenoid cartilages in the larynx. By rotating the arytenoid cartilages laterally, these muscles abduct the vocal cords and thereby open the rima glottidis. Their action opposes the lateral cricoarytenoid muscles. The posterior cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X). Paralysis of the posterior cricoarytenoid muscles may lead to asphyxiation as they are the only laryngeal muscles to open the true vocal folds, allowing inspiration and expiration." . [] oboInOwl:hasDbXref "FMA:46576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "posterior cricoarytenoid" . _:genid145614 oboInOwl:hasDbXref "Wikipedia:Posterior_cricoarytenoid_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "posterior cricoarytenoid muscle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004709 . [] oboInOwl:hasDbXref "FMA:46576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "posterior cricoarytenoideus" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "cricoarytaenoideus posterior" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "cricoarytænoideus posterior" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_cricoarytenoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008572 ; owl:annotatedTarget "musculus cricoarytenoideus posterior" . [] oboInOwl:notes "recurrent laryngeal branch of the vagus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget _:genid147301 . [] oboInOwl:notes "lateral part of the arch of the cricoid" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget _:genid147303 . [] oboInOwl:notes "muscular process of the arytenoid cartilage" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget _:genid147305 . _:genid145622 oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget _:genid147307 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003076 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "The lateral cricoarytenoid (also anterior cricoarytenoid) muscles extend from the lateral cricoid cartilage to the ipsilateral arytenoid cartilage. By rotating the arytenoid cartilages medially, these muscles adduct the vocal cords and thereby close the rima glottidis, protecting the airway. (Their action is antagonistic to that of the posterior cricoarytenoid muscles. ) The lateral cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X)." . _:genid145624 oboInOwl:hasDbXref "FMA:46579" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "lateral cricoarytenoid" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003852 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "lateral cricoarytenoid muscle" . [] oboInOwl:hasDbXref "FMA:46579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "lateral cricoarytenoideus" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "cricoarytaenoideus lateralis" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "cricoarytaenoideus lateralis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "cricoarytænoideus lateralis" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "cricoarytænoideus lateralis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_cricoarytenoid_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008573 ; owl:annotatedTarget "musculus cricoarytenoideus lateralis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget obo:UBERON_0003682 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget _:genid147319 . [] oboInOwl:notes "Pharyngeal Branch of Vagus" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget _:genid147321 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget _:genid147323 . _:genid145636 oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "The levator veli palatini is the elevator muscle of the velum palatinum in the human body. During swallowing, it contracts, elevating the soft palate to help prevent food from entering the nasopharynx. It is innervated via the pharyngeal plexus, primarily by the vagus nerve (CN X). The levator veli palatini (Levator palati) is a thick, rounded muscle situated lateral to the choanC&. It arises from the under surface of the apex of the petrous part of the temporal bone and from the medial lamina of the cartilage of the auditory tube. After passing above the upper concave margin of the Constrictor pharyngis superior it spreads out in the palatine velum, its fibers extending obliquely downward and medially to the middle line, where they blend with those of the opposite side." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004141 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "The levator veli palatini is part of the soft palate that attaches to the cranial base, pharyngotympanic tube and the soft palate and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" . [] oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "levator palati" . [] oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "levator veli" . [] oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "levator veli palatini muscle" . [] oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "levator velum palatini muscle" . [] oboInOwl:hasDbXref "Wikipedia:Levator_veli_palatini" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008585 ; owl:annotatedTarget "musculus levator veli palatini" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget obo:UBERON_0008522 . [] oboInOwl:notes "Temporal Branch of the facial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget _:genid147333 . [] oboInOwl:hasDbXref "Wikipedia:Procerus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget "The Procerus is a small pyramidal slip of muscle deep to the superior orbital nerve, artery and vein." . [] oboInOwl:hasDbXref "Wikipedia:Procerus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget "depressor glabellae" . [] oboInOwl:hasDbXref "Wikipedia:Procerus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget "musculus procerus glabellae" . [] oboInOwl:hasDbXref "Wikipedia:Procerus_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget "procerus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Procerus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008588 ; owl:annotatedTarget "pyramidalis nasi" . _:genid145658 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0006238, obo:UBERON_0011386 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget obo:UBERON_0010437 . [] oboInOwl:notes "zygomatic branch of facial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget _:genid147353 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget _:genid147355 . [] oboInOwl:hasDbXref "MFMO:0000138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." . _:genid145667 oboInOwl:source "ncithesaurus:Zygomaticus_Major" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "UMLS:C0224115" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009618 . [] oboInOwl:hasDbXref "MFMO:0000138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "zygomatic muscle" . [] oboInOwl:hasDbXref "MFMO:0000138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "auriculolabialis superior" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticus_major_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "musculus zygomaticus major" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticus_major_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "zygomatic major" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticus_major_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "zygomatic major muscle" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticus_major_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "zygomaticcus major" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticus_major_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008593 ; owl:annotatedTarget "zygomaticus major" . _:genid145681 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006598 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000307 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0003077 ] ) ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0010933 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget _:genid147379 . [] oboInOwl:hasDbXref "MFMO:0000138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. This muscle is ventral to the zygomaticus minor and dorsal to the platysma muscle. In many mammals this muscle also has an attachment to the cartilage of the external ear, in which case it is called the auriculolabialis inferior. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." . [] oboInOwl:source "ncithesaurus:Zygomaticus_Minor" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "UMLS:C0224116" . [] oboInOwl:hasDbXref "MFMO:0000137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "musculus quadratus labii superioris, zygomatic head" . [] oboInOwl:hasDbXref "MFMO:0000137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "musculus zygomaticus minor" . [] oboInOwl:hasDbXref "MFMO:0000137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "square muscle of the upper lip, zygomatic head" . [] oboInOwl:hasDbXref "MFMO:0000137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008594 ; owl:annotatedTarget "auriculolabialis superior" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:notes "buccal branches" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget _:genid147388 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget _:genid147390 . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "The levator anguli oris (caninus) is a facial muscle of the mouth arising from the canine fossa, immediately below the infraorbital foramen. Its fibers are inserted into the angle of the mouth, intermingling with those of the Zygomaticus, Triangularis, and Orbicularis oris." . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "levator anguli oris muscle" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "CAS:57-88-5" . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "caninus" . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "caninus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "levator anguli oris" . [] oboInOwl:hasDbXref "Wikipedia:Levator_anguli_oris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008595 ; owl:annotatedTarget "musculus levator anguli oris" . [] oboInOwl:source "MFMO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget _:genid147408 . [] oboInOwl:notes "mandibular branch" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget _:genid147410 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget _:genid147412 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget _:genid147414 . [] oboInOwl:hasDbXref "MFMO:0000122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget "A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip and inferior to the lower lip (in humans this region is called the chin or mental region), the orbicularis oris muscle, and the mandible in the symphyseal region. See Diogo et al., 2009; Burrows et al., 2011)." . [] oboInOwl:source "FEED" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002171 ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget obo:UBERON_0001581 . [] oboInOwl:hasDbXref "MFMO:0000122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget "mentalis" . [] oboInOwl:hasDbXref "Wikipedia:Mentalis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008596 ; owl:annotatedTarget "musculus mentalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:notes "mandibular branch" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget _:genid147421 . [] oboInOwl:notes "tubercle of mandible" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget _:genid147423 . [] oboInOwl:notes "modiolus of mouth" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget _:genid147425 . [] oboInOwl:hasDbXref "Wikipedia:Depressor_anguli_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "The Depressor anguli oris (Triangularis) arises from the oblique line of the mandible, whence its fibers converge, to be inserted, by a narrow fasciculus, into the angle of the mouth." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "EMAPA:37842" . [] oboInOwl:hasDbXref "Wikipedia:Depressor_anguli_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "depressor anguli oris" . [] oboInOwl:hasDbXref "Wikipedia:Depressor_anguli_oris_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "musculus depressor anguli oris" . [] oboInOwl:hasDbXref "Wikipedia:Depressor_anguli_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "triangularis" . [] oboInOwl:hasDbXref "Wikipedia:Depressor_anguli_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008597 ; owl:annotatedTarget "triangularis muscle" . [] oboInOwl:source "MFMO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008598 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:notes "buccal branch" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008598 ; owl:annotatedTarget _:genid147444 . [] oboInOwl:hasDbXref "MFMO:0000141" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008598 ; owl:annotatedTarget "Facial muscle that attaches to the fascia of the masseter muscle and the facia of the skin in the region of the corner (angle) of the mouth. Even in species in which this muscle is present, it is highly variable. A true risorius muscle may only be present in Hominins (humans and great apes). See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980." . [] oboInOwl:hasDbXref "Wikipedia:Risorius" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008598 ; owl:annotatedTarget "musculus risorius" . [] oboInOwl:hasDbXref "MFMO:0000141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008598 ; owl:annotatedTarget "risorius" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008715 ; owl:annotatedTarget "A muscle tissue that is part of a prostate gland." . _:genid145752 oboInOwl:source "ncithesaurus:Prostatic_Muscular_Tissue" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008715 ; owl:annotatedTarget "UMLS:C1183911" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005309 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008715 ; owl:annotatedTarget "prostate gland muscle tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008715 ; owl:annotatedTarget "prostate muscle tissue" . _:genid145759 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008772 ; owl:annotatedTarget "A proximal epiphysis that is part of a tibia." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004739 . [] oboInOwl:source "ncithesaurus:Head_of_the_Tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008772 ; owl:annotatedTarget "UMLS:C0932431" . [] oboInOwl:hasDbXref "FMA:33113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008772 ; owl:annotatedTarget "head of tibia" . [] oboInOwl:hasDbXref "FMA:33113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008772 ; owl:annotatedTarget "proximal end of tibia" . [] oboInOwl:hasDbXref "FMA:33113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008772 ; owl:annotatedTarget "upper end of tibia" . _:genid145768 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "A proximal epiphysis that is part of a fibula." ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0006867 . [] oboInOwl:source "Wikipedia:Head_of_fibula" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "The upper extremity or head of the fibula is of an irregular quadrate form, presenting above a flattened articular surface, directed upward, forward, and medialward, for articulation with a corresponding surface on the lateral condyle of the tibia. On the lateral side is a thick and rough prominence continued behind into a pointed eminence, the apex, which projects upward from the posterior part of the head. The prominence, at its upper and lateral part, gives attachment to the tendon of the Biceps femoris and to the fibular collateral ligament of the knee-joint, the ligament dividing the tendon into two parts. The remaining part of the circumference of the head is rough, for the attachment of muscles and ligaments. It presents in front a tubercle for the origin of the upper and anterior fibers of the Peronæus longus, and a surface for the attachment of the anterior ligament of the head; and behind, another tubercle, for the attachment of the posterior ligament of the head and the origin of the upper fibers of the Soleus[Wikipedia:Head_of_fibula]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "EMAPA:37890" . [] oboInOwl:source "ncithesaurus:Head_of_the_Fibula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "UMLS:C0223908" . [] oboInOwl:hasDbXref "Wikipedia:Head_of_fibula" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "caput fibulae" . [] oboInOwl:hasDbXref "FMA:33729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "head of fibula" . [] oboInOwl:hasDbXref "FMA:33729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "proximal end of fibula" . [] oboInOwl:hasDbXref "FMA:33729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "upper end of fibula" . [] oboInOwl:hasDbXref "FMA:33729" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008775 ; owl:annotatedTarget "fibular head" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget _:genid147484 . [] oboInOwl:hasDbXref "Wikipedia:Epaxial_and_Hypaxial_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "Musculature that is derived from the hypaxial myotome region, trunk muscles that lie ventral to the horizontal septum of the vertebrae. Hypaxial muscles include some vertebral muscles, the diaphragm, the abdominal muscles, and all limb muscles." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000228" ; oboInOwl:ontology "AAO" ; oboInOwl:source "UBERON:0008777" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "Trunk muscle that lies ventral to the horizontal septum of the vertebrae.[AAO]" . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "The hypaxial muscles are located on the lower side of the body, often below the horizontal septum in many species (primarily fish and amphibians). In amniotes, the positional distinctions have been lost as the body's muscles have changed through evolution, but in all species, the hypaxial muscles are innervated by the ventral ramus of the spinal nerves, while the epaxial muscles are innervated by the dorsal ramus." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "EMAPA:37852" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "hypaxial muscles" . [] oboInOwl:hasDbXref "XAO:0003228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008777 ; owl:annotatedTarget "hypaxial muscle" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget _:genid147497 . [] oboInOwl:hasDbXref "Wikipedia:Epaxial_and_hypaxial_muscles", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "Musculature that is derived from the epaxial myotome region, ventral to the horizontal septum of the vertebrae. Epaxial muscles include other (dorsal) muscles associated with the vertebrae, ribs, and base of the skull." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000142" ; oboInOwl:ontology "AAO" ; oboInOwl:source "XAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "Trunk muscles that lies dorsal to the horizontal septum.[AAO]" . _:genid145797 oboInOwl:source "MP:0004248,PMID:1591996" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "the muscles derived from the medial myotome; includes the intrinsic back muscles" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000017 . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "The hypaxial muscles are located on the lower side of the body, often below the horizontal septum in many species (primarily fish and amphibians). In amniotes, the positional distinctions have been lost as the body's muscles have changed through evolution, but in all species, the hypaxial muscles are innervated by the ventral ramus of the spinal nerves, while the epaxial muscles are innervated by the dorsal ramus." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "EMAPA:37851" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "CAS:57-88-5" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002002 ; owl:annotatedTarget obo:CL_0000557 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "epaxial muscles" . [] oboInOwl:hasDbXref "XAO:0003229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008778 ; owl:annotatedTarget "epaxial muscle" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008780 ; owl:annotatedTarget _:genid147512 . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008780 ; owl:annotatedTarget "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers." . [] oboInOwl:source "ncithesaurus:Epiblast" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008780 ; owl:annotatedTarget "UMLS:C1516906" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:16322423", "PMID:19022770", "PMID:19273628", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002002 ; owl:annotatedTarget "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." . [] oboInOwl:hasDbXref "MP:0003886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008780 ; owl:annotatedTarget "embryonic epiblast" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget obo:UBERON_0001638 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_venous_arch_of_the_foot" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget "The dorsal venous arch of the foot is a superficial vein that connects the small saphenous vein and the great saphenous vein. Anatomically, it is defined by where the dorsal veins of the first and fifth digit, respectively, meet the great saphenous vein and small saphenous vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget "EMAPA:37521" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_venous_arch_of_the_foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget "arcus venosus dorsalis pedis" . [] oboInOwl:hasDbXref "FMA:44356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget "dorsal venous arch of foot" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_venous_arch_of_the_foot" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008783 ; owl:annotatedTarget "arcus venosus dorsalis pedis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008784 ; owl:annotatedTarget "A limb segment that is part of a hindlimb." . [] oboInOwl:hasDbXref "FMA:24877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008784 ; owl:annotatedTarget "free lower limb segment" . [] oboInOwl:hasDbXref "FMA:24877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008784 ; owl:annotatedTarget "free lower limb subdivision" . [] oboInOwl:hasDbXref "FMA:24877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008784 ; owl:annotatedTarget "segment of free lower limb" . [] oboInOwl:hasDbXref "FMA:24877" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008784 ; owl:annotatedTarget "subdivision of free lower limb" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008785 ; owl:annotatedTarget "A limb segment that is part of a forelimb." . [] oboInOwl:hasDbXref "FMA:24876" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008785 ; owl:annotatedTarget "free upper limb segment" . [] oboInOwl:hasDbXref "FMA:24876" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008785 ; owl:annotatedTarget "free upper limb subdivision" . [] oboInOwl:hasDbXref "FMA:24876" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008785 ; owl:annotatedTarget "segment of free upper limb" . [] oboInOwl:hasDbXref "FMA:24876" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008785 ; owl:annotatedTarget "subdivision of free upper limb" . [] oboInOwl:hasDbXref "MESH:A01.456.830.200", "Wikipedia:Posterior_cranial_fossa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008788 ; owl:annotatedTarget "The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE." . [] oboInOwl:hasDbXref "ncithesaurus:Posterior" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0008788 ; owl:annotatedTarget "posterior fossa" . [] oboInOwl:source "ncithesaurus:Posterior_Fossa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008788 ; owl:annotatedTarget "UMLS:C0010265" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_cranial_fossa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008788 ; owl:annotatedTarget "fossa cranii posterior" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008789 ; owl:annotatedTarget _:genid147553 . [] oboInOwl:hasDbXref "http://mw1.merriam-webster.com/medical/cranial%20fossa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008789 ; owl:annotatedTarget "Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity." . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008801 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008803 ; owl:annotatedTarget "A zone of skin that is part of a cheek." . [] oboInOwl:hasDbXref "FMA:24759" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008803 ; owl:annotatedTarget "cheek skin" . [] oboInOwl:hasDbXref "Wikipedia:Gingival_sulcus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008805 ; owl:annotatedTarget "The gingival sulcus is an area of potential space between a tooth and the surrounding gingival tissue and is lined by sulcular epithelium. The depth of the sulcus (Latin for groove) is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin." . [] oboInOwl:hasDbXref "FMA:74580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008805 ; owl:annotatedTarget "gingival sulcus" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008805 ; owl:annotatedTarget "sulcus gingivalis" . [] oboInOwl:hasDbXref "Wikipedia:Gingival_sulcus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008805 ; owl:annotatedTarget "sulcus gingivalis" . [] oboInOwl:hasDbXref "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/nasopalatine+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "A branch of that maxillary nerve that innervates the mucous membrane of the hard palate." . [] oboInOwl:hasDbXref "FMA:52797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "Scarpa's nerve" . [] oboInOwl:hasDbXref "Wikipedia:Nasopalatine_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "naso-palatine nerve" . [] oboInOwl:hasDbXref "Wikipedia:Nasopalatine_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "nasopalatine" . [] oboInOwl:hasDbXref "Wikipedia:Nasopalatine_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "nasopalatine nerves" . [] oboInOwl:hasDbXref "Wikipedia:Nasopalatine_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008810 ; owl:annotatedTarget "nervus nasopalatinus" . [] oboInOwl:hasDbXref "Wikipedia:Intromittent_organ" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008811 ; owl:annotatedTarget "An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002036" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008811 ; owl:annotatedTarget "Surface structure that is an external structure of a male organism through which sperm is transferred to a female organism during mating.[TAO]" . [] oboInOwl:hasDbXref "FBbt:00004850" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0008811 ; owl:annotatedTarget "aedeagus" . [] oboInOwl:hasDbXref "GO:0060037", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008814 ; owl:annotatedTarget "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." . [] oboInOwl:source "ncithesaurus:Pharyngeal_Apparatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008814 ; owl:annotatedTarget "UMLS:C1519038" . [] oboInOwl:hasDbXref "GO:0060037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008814 ; owl:annotatedTarget "pharyngeal system" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002003 ; owl:annotatedTarget obo:CL_0001066 . [] oboInOwl:hasDbXref "EHDAA2:0000187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008814 ; owl:annotatedTarget "pharyngeal arch region" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008816 ; owl:annotatedTarget "A head that is part of a embryo." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "CAS:57-88-5" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19621348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002003 ; owl:annotatedTarget "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." . [] oboInOwl:source "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008817 ; owl:annotatedTarget _:genid147607 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008817 ; owl:annotatedTarget "An endoderm that is part of a thymus primordium." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008823 ; owl:annotatedTarget obo:UBERON_0000489 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008823 ; owl:annotatedTarget _:genid147615 . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008823 ; owl:annotatedTarget _:genid147617 . [] oboInOwl:hasDbXref "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008823 ; owl:annotatedTarget "A brain that develops_from a neural tube." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget obo:UBERON_0000058 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget _:genid147625 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget "Any duct branching of of the main epididymis duct." . [] oboInOwl:source "ncithesaurus:Duct_of_the_Epididymis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget "UMLS:C0458632" . [] oboInOwl:hasDbXref "MA:0001735" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget "epididymal duct" . [] oboInOwl:hasDbXref "FMA:18297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008824 ; owl:annotatedTarget "epididymis duct" . [] oboInOwl:hasDbXref "Wikipedia:Pulmonary_surfactant" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008826 ; owl:annotatedTarget "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein)." . [] oboInOwl:source "ncithesaurus:Lung_Surfactant" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008826 ; owl:annotatedTarget "UMLS:C0034085" . [] oboInOwl:hasDbXref "FMA:62780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008826 ; owl:annotatedTarget "alveolar surfactant" . [] oboInOwl:hasDbXref "MA:0002534" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008826 ; owl:annotatedTarget "lung surfactant" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget _:genid147640 . [] oboInOwl:source "FMA", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget _:genid147642 . [] oboInOwl:hasDbXref "Wikipedia:Great_auricular_nerve", "http://medical-dictionary.thefreedictionary.com/great+auricular+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget "A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw." . [] oboInOwl:hasDbXref "Wikipedia:Great_auricular_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget "nervus auricularis magnus" . [] oboInOwl:hasDbXref "Wikipedia:Great_auricular_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget "great auricular" . [] oboInOwl:hasDbXref "Wikipedia:Great_auricular_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008833 ; owl:annotatedTarget "greater auricular nerve" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:notes "caudal part" ; oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget _:genid147650 . _:genid145938 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget _:genid147652 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget _:genid147654 . [] oboInOwl:hasDbXref "MP:MP", "http://www.stembook.org/node/512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." . [] oboInOwl:source "ncithesaurus:Hepatic_Diverticulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget "UMLS:C1512407" . [] oboInOwl:hasDbXref "XAO:0000101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget "liver diverticulum" . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_diverticulum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008835 ; owl:annotatedTarget "diverticulum hepaticum" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008836 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008836 ; owl:annotatedTarget _:genid147661 . [] oboInOwl:source "http://www.stembook.org/node/512" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008836 ; owl:annotatedTarget _:genid147663 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008841 ; owl:annotatedTarget "A ligament that supports a body part, especially an organ." . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008842 ; owl:annotatedTarget obo:UBERON_0008841 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008842 ; owl:annotatedTarget _:genid147672 . [] oboInOwl:hasDbXref "Wikipedia:Scrotal_ligament", "http://www.medilexicon.com/medicaldictionary.php?t=49790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008842 ; owl:annotatedTarget "The cranial atrophic portion of the urogenital ridge attached to the cranial pole of the intraabdominal embryonic testis." . [] oboInOwl:hasDbXref "Wikipedia:Gubernaculum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008842 ; owl:annotatedTarget "scrotal ligament" . [] oboInOwl:hasDbXref "BTO:0002813" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008843 ; owl:annotatedTarget "The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies." . [] oboInOwl:hasDbXref "MA:0003248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0008843 ; owl:annotatedTarget "gubernaculum" . [] oboInOwl:hasDbXref "BTO:0002813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008843 ; owl:annotatedTarget "Hunter's gubernaculum" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008844 ; owl:annotatedTarget "A gubernaculum that is part of a female reproductive system." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008845 ; owl:annotatedTarget obo:UBERON_0000211 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008845 ; owl:annotatedTarget "A ligament that does not connect two skeletal elements." . [] oboInOwl:source "FMA:25625" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008845 ; owl:annotatedTarget "Ligament organ that primarily consists of dense connective tissue aggregated into fasciculi which may be admixed with smooth muscle. Examples: ligament of liver, ovarian ligament[FMA:25625]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008845 ; owl:annotatedTarget "this class is used more generally than the FMA class, to include for example folds of mesentery such as the broad ligament of the uterus." . [] oboInOwl:hasDbXref "Wikipedia:Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008845 ; owl:annotatedTarget "fibrous ligament" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002004 ; owl:annotatedTarget obo:CL_0000547 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget _:genid147704 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget _:genid147706 . [] oboInOwl:notes "bones or cartilage organs" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget _:genid147708 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget _:genid147710 . _:genid145989 oboInOwl:hasDbXref "GO_REF:0000034", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified]." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19621348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002004 ; owl:annotatedTarget "A proerythoblast that is CD34-negative and GlyA-negative." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000072" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.[VSAO]" . [] oboInOwl:source "FMA:25624" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "Ligament organ that primarily consists of regular dense connective tissue aggregated into fasciculi; connects bone and cartilage organs. Examples: sutural ligament, ligament of pinna, tarsal ligament[FMA:25624]." . [] oboInOwl:hasDbXref "VSAO:0000072", "ZFA:0001675" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "ligament" . _:genid145993 oboInOwl:hasDbXref "Wikipedia:Ligament" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "articular larua" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 . [] oboInOwl:hasDbXref "Wikipedia:Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "articular ligament" . _:genid145995 oboInOwl:hasDbXref "Wikipedia:Ligament" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008846 ; owl:annotatedTarget "true ligament" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000327 . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Gmelin:550297" . [] oboInOwl:hasDbXref "MP:0011165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008854 ; owl:annotatedTarget "The part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008854 ; owl:annotatedTarget "EMAPA:37948" . [] oboInOwl:hasDbXref "MP:0011166" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008854 ; owl:annotatedTarget "molar root" . [] oboInOwl:hasDbXref "FMA:85302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008854 ; owl:annotatedTarget "molar tooth root" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget _:genid147731 . [] oboInOwl:source "MA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget _:genid147733 . [] oboInOwl:hasDbXref "MP:0010779" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "the muscularis externa in the stomach differs from that of other GI organs in that it has three layers of smooth muscle instead of two" . [] oboInOwl:hasDbXref "FMA:14909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "gastric muscularis" . [] oboInOwl:hasDbXref "FMA:14909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "muscle layer of stomach" . [] oboInOwl:hasDbXref "FMA:14909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "muscularis externa of stomach" . [] oboInOwl:hasDbXref "FMA:14909" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008856 ; owl:annotatedTarget "tunica muscularis (gaster)" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget obo:UBERON_0009870 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget _:genid147745 . [] oboInOwl:hasDbXref "MP:0010791", "Wikipedia:Pyloric_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget "EMAPA:37944" . [] oboInOwl:hasDbXref "Wikipedia:Pyloric_canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget "canalis pyloricus" . [] oboInOwl:hasDbXref "Wikipedia:Pyloric_canal" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008858 ; owl:annotatedTarget "canalis pyloricus" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget obo:UBERON_0000414 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget _:genid147760 . [] oboInOwl:source "Wikipedia:Tubular_gland" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget _:genid147762 . [] oboInOwl:hasDbXref "MP:0010797", "Wikipedia:Pyloric_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." . [] oboInOwl:source "ncithesaurus:Pyloric_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget "UMLS:C0227239" . [] oboInOwl:hasDbXref "FMA:14922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget "glandula pylorica" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget "pyloric antrum gland" . [] oboInOwl:hasDbXref "FMA:14922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008861 ; owl:annotatedTarget "pyloric gland" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008867 ; owl:annotatedTarget _:genid147770 . [] oboInOwl:hasDbXref "MP:0010867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008867 ; owl:annotatedTarget "The network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force." . [] oboInOwl:source "ncithesaurus:Bone_Trabeculae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008867 ; owl:annotatedTarget "UMLS:C2826619" . [] oboInOwl:hasDbXref "MP:0010867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008867 ; owl:annotatedTarget "bone trabecula" . [] oboInOwl:hasDbXref "MP:0010867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008867 ; owl:annotatedTarget "bone trabeculae" . [] oboInOwl:hasDbXref "MP:0010901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008870 ; owl:annotatedTarget "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008870 ; owl:annotatedTarget "EMAPA:37942" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget obo:UBERON_0010368 . [] oboInOwl:hasDbXref "MP:0010911", "Wikipedia:Acinus#The_Lungs" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "The part of the airway consisting of a respiratory bronchiole and all of its branches." . _:genid146057 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "EMAPA:37941" ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002384 . [] oboInOwl:source "ncithesaurus:Pulmonary_Acinus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "UMLS:C0225696" . [] oboInOwl:hasDbXref "FMA:7313", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "acinus pulmonaris" . [] oboInOwl:hasDbXref "FMA:7313", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "arbor alveolaris" . [] oboInOwl:hasDbXref "FMA:7313", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "lobulus pulmonis primarius" . [] oboInOwl:hasDbXref "FMA:7313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008874 ; owl:annotatedTarget "primary pulmonary lobule" . [] oboInOwl:source "MP-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008876 ; owl:annotatedTarget _:genid147796 . [] oboInOwl:hasDbXref "ISBN:0123813611", "MP:0011157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008876 ; owl:annotatedTarget "Any skeletal muscle organ in the hypodermis / superficial fascia." . [] oboInOwl:hasDbXref "MP:0011157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008876 ; owl:annotatedTarget "hypodermal muscle layer" . [] oboInOwl:hasDbXref "MP:0011157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008876 ; owl:annotatedTarget "hypodermis muscle layer" . [] oboInOwl:hasDbXref "MP:0011157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0008876 ; owl:annotatedTarget "panniculus carnosus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget obo:UBERON_0005451 . [] oboInOwl:source "ncithesaurus:Palmar_Region" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "UMLS:C0931849" . [] oboInOwl:hasDbXref "FMA:24920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "front of hand" . [] oboInOwl:hasDbXref "FMA:24920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "palm" . _:genid146079 oboInOwl:hasDbXref "FMA:24920" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "palm of hand" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001486 . [] oboInOwl:hasDbXref "FMA:24920" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "palmar region" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008878 ; owl:annotatedTarget "regio palmaris" . [] oboInOwl:hasDbXref "MP:0009694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008882 ; owl:annotatedTarget "The nerve fiber tracts that span the midline of the spinal cord." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008882 ; owl:annotatedTarget "EMAPA:37955" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget obo:UBERON_0002481 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000046", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000046" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.[VSAO]" . [] oboInOwl:reference "ISBN:0-683-40008-8" ; oboInOwl:source "MP:0010924" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "Newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalci[ISBN:0-683-40008-8]n" . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "Note that in VSAO this was classified both as tissue and acellular extracellular matrix. Consider also the AEO class 'bone condensation'. is_a intercellular matrix in FMA." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "EMAPA:37923" . [] oboInOwl:source "ncithesaurus:Osteoid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "UMLS:C0682561" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "osteoid tissue" . [] oboInOwl:hasDbXref "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "pre-bone" . _:genid146098 oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "prebone" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0003023 . [] oboInOwl:hasDbXref "FMA:66830", "MP:0002113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008883 ; owl:annotatedTarget "prebone tissue" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST01010001" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002005 ; owl:annotatedTarget obo:CL_0000050 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008884 ; owl:annotatedTarget "A putamen that is part of a left cerebral hemisphere." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008885 ; owl:annotatedTarget "A putamen that is part of a right cerebral hemisphere." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:190227700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002005 ; owl:annotatedTarget "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget obo:UBERON_0007798 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget _:genid147841 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Pulmonary_circulation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." . [] oboInOwl:ontology "FMA" ; oboInOwl:source "FMA:45621" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget "Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA]" . [] oboInOwl:hasDbXref "FMA:45621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget "pulmonary circulatory system" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008886 ; owl:annotatedTarget "pulmonary system" . (obo:UBERON_0001593 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0001052 ] ) . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget obo:UBERON_0001593 . [] oboInOwl:hasDbXref "Wikipedia:Rectal_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "The hemorrhoidal plexus (or rectal venous plexus) surrounds the rectum, and communicates in front with the vesical venous plexus in the male, and the uterovaginal plexus in the female. A free communication between the portal and systemic venous systems is established through the hemorrhoidal plexus." . [] oboInOwl:source "ncithesaurus:Hemorrhoidal_Plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "UMLS:C0226766" . [] oboInOwl:hasDbXref "Wikipedia:Rectal_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "haemorrhoidal plexus" . [] oboInOwl:hasDbXref "Wikipedia:Rectal_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "hemorrhoidal plexus" . [] oboInOwl:hasDbXref "Wikipedia:Rectal_venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "plexus haemorrhoidalis" . [] oboInOwl:hasDbXref "Wikipedia:Rectal_venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008887 ; owl:annotatedTarget "plexus venosus rectalis" . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/83" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget _:genid147860 . [] oboInOwl:notes "redundant" ; oboInOwl:source "Grays", "PMID:11237469" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget _:genid147862 . _:genid146131 oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Facial_skeleton", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "Subdivision of endoskeleton derived from pharyngeal arches." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007213 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001216" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010157" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000315" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000315" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.242, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.235", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG]" . [] oboInOwl:external_ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "pharyngeal endoskeleton" . _:genid146138 oboInOwl:hasDbXref "VHOG:0000315", "Wikipedia:Viscerocranium", "ZFA:0001216" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "viscerocranium" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009617 . [] oboInOwl:hasDbXref "VSAO:0000149" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "pharyngeal arch" . _:genid146140 oboInOwl:hasDbXref "ZFA:0001216" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "pharyngeal arch skeleton" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0007213 . [] oboInOwl:hasDbXref "ZFA:0001216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "pharyngeal skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "visceral cranium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "visceral skeletal system" . [] oboInOwl:hasDbXref "UBERONREF:0000007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008895 ; owl:annotatedTarget "visceral skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010362" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "Posterior-most stream of cranial neural crest, which sub-divides during migration.[AAO]" . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "branchial arch" . _:genid146152 oboInOwl:hasDbXref "ZFA:0001613" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "branchial arches" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "branchial bar" . [] oboInOwl:hasDbXref "ZFA:0001613" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "branchial bars" . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "gill arch" . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "gill arches 1-5" . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "pharyngeal arch 3-7" . [] oboInOwl:hasDbXref "ZFA:0001613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "visceral arches 3-7" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008896 ; owl:annotatedTarget "gill bar" . [] oboInOwl:source "wd" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget obo:UBERON_0004756 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget obo:UBERON_0007842 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget _:genid147899 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000130", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." . _:genid146168 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001590" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget "Intramembranous bone that forms superficially in the organism.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042 . [] oboInOwl:hasDbXref "ZFA:0001590" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008907 ; owl:annotatedTarget "dermal bones" . [] oboInOwl:notes "not in VSAO" ; oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008909 ; owl:annotatedTarget obo:UBERON_0012075 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000307", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008909 ; owl:annotatedTarget "Bone element that is adjacent to the notochord." . _:genid146176 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001639" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0008909 ; owl:annotatedTarget "Replacement bone that forms within the connective tissue surrounding the notochord.[TAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009722 . [] oboInOwl:hasDbXref "ZFA:0001629" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008909 ; owl:annotatedTarget "perichordal bones" . _:genid146178 oboInOwl:hasDbXref "ZFA:0001629" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008909 ; owl:annotatedTarget "perichordal bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget obo:UBERON_0000353 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget _:genid147918 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget "A parenchyma that is part of a lung." . [] oboInOwl:hasDbXref "FMA:27360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget "respiratory portion of lung" . [] oboInOwl:hasDbXref "BTO:0000763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget "parenchyma of lung" . [] oboInOwl:hasDbXref "EMAPA:35522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008946 ; owl:annotatedTarget "pulmonary parenchyma" . _:genid146189 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001727, obo:UBERON_0003258 . [] oboInOwl:source "Obol" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008947 ; owl:annotatedTarget obo:UBERON_0001048 . [] oboInOwl:source "ncithesaurus:Respiratory_Primordium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008947 ; owl:annotatedTarget "UMLS:C1514898" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008962 ; owl:annotatedTarget "A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder." . [] oboInOwl:source "ncithesaurus:Bone_of_the_Upper_Extremity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008962 ; owl:annotatedTarget "UMLS:C0003793" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:10901445" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008962 ; owl:annotatedTarget "free forelimb bone" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0008962 ; owl:annotatedTarget "wing bone" . [] oboInOwl:source "PMID:19767574" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008969 ; owl:annotatedTarget _:genid147939 . [] oboInOwl:hasDbXref "Wikipedia:Dental_follicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008969 ; owl:annotatedTarget "A sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively." . [] oboInOwl:hasDbXref "MA:0003121", "Wikipedia:Dental_follicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008969 ; owl:annotatedTarget "dental sac" . _:genid146207 oboInOwl:hasDbXref "BTO:0000337" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008969 ; owl:annotatedTarget "tooth follicle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0008974 ; owl:annotatedTarget obo:UBERON_0010243 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008974 ; owl:annotatedTarget "Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008982 ; owl:annotatedTarget obo:UBERON_0007846 . [] oboInOwl:notes "fasciae connect muscles to other muscles" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008982 ; owl:annotatedTarget _:genid147948 . [] oboInOwl:hasDbXref "Wikipedia:Fascia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008982 ; owl:annotatedTarget "A dense regular connective tissue that that connects muscles together[WP, modified]." . [] oboInOwl:source "ncithesaurus:Fascia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008982 ; owl:annotatedTarget "UMLS:C0015641" . _:genid146216 oboInOwl:hasDbXref "FMA:30318" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008982 ; owl:annotatedTarget "fascia cluster" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008987 ; owl:annotatedTarget obo:UBERON_0000353 . _:genid146222 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0008987 ; owl:annotatedTarget _:genid147959 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003023 . [] oboInOwl:hasDbXref "BTO:0003604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008987 ; owl:annotatedTarget "The functional tissue of the kidney, consisting of the nephrons." . [] oboInOwl:hasDbXref "FMA:15574" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008987 ; owl:annotatedTarget "parenchyma of kidney" . [] oboInOwl:hasDbXref "BTO:0003604" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0008987 ; owl:annotatedTarget "kidney parenchyma" . [] oboInOwl:hasDbXref "BTO:0003634", "Wikipedia:Esophageal_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008989 ; owl:annotatedTarget "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." . [] oboInOwl:source "ncithesaurus:Esophageal_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0008989 ; owl:annotatedTarget "UMLS:C0227178" . [] oboInOwl:hasDbXref "FMA:9404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008989 ; owl:annotatedTarget "esophageal gland" . [] oboInOwl:hasDbXref "Wikipedia:Esophageal_glands" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008989 ; owl:annotatedTarget "glandulae oesophageae" . [] oboInOwl:hasDbXref "FMA:9404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008989 ; owl:annotatedTarget "mucous gland of submucosa of esophagus" . _:genid146240 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001449, obo:UBERON_0002130 . [] oboInOwl:hasDbXref "BTO:0003835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008995 ; owl:annotatedTarget "Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii." . [] oboInOwl:hasDbXref "BTO:0003835" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008995 ; owl:annotatedTarget "cerebellar nucleus" . [] oboInOwl:hasDbXref "BTO:0003840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0008998 ; owl:annotatedTarget "System pertaining to blood vessels in the brain." . [] oboInOwl:hasDbXref "BTO:0003840" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008998 ; owl:annotatedTarget "cerebrovascular system" . [] oboInOwl:hasDbXref "FMA:61935" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0008998 ; owl:annotatedTarget "intracerebral vasculature" . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009002 ; owl:annotatedTarget _:genid147987 . [] oboInOwl:hasDbXref "BTO:0004196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009002 ; owl:annotatedTarget "The membrane separating the fetal from the maternal blood in the placenta." . [] oboInOwl:source "ncithesaurus:Placental_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009002 ; owl:annotatedTarget "UMLS:C0230984" . _:genid146254 oboInOwl:hasDbXref "BTO:0004196" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009002 ; owl:annotatedTarget "placental barrier" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001436 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009010 ; owl:annotatedTarget "Any portion of tissue that surrounds a urethra." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009014 ; owl:annotatedTarget obo:UBERON_0003836 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009014 ; owl:annotatedTarget "A zone of skin that is part of a lower back." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009014 ; owl:annotatedTarget "EMAPA:37281" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009015 ; owl:annotatedTarget obo:UBERON_0001418 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009015 ; owl:annotatedTarget "A zone of skin that is part of a dorsal thoracic segment of trunk." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009015 ; owl:annotatedTarget "EMAPA:37280" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009027 ; owl:annotatedTarget "An artery that supplies blood to the urinary bladder." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002006 ; owl:annotatedTarget obo:CL_0000050 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009027 ; owl:annotatedTarget "EMAPA:37131" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009027 ; owl:annotatedTarget "arteria vesicali" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009027 ; owl:annotatedTarget "vesical arteries" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009029 ; owl:annotatedTarget obo:UBERON_0001638 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://veintreatmentcenter.com/vein-information/pudendal-veins/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009029 ; owl:annotatedTarget "Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009029 ; owl:annotatedTarget "EMAPA:37184" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009029 ; owl:annotatedTarget "vena pudendae" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009029 ; owl:annotatedTarget "vena pudendales" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12615892", "PMID:19022770", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002006 ; owl:annotatedTarget "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009030 ; owl:annotatedTarget "Vein that drains left lung and returns blood to the heart." . [] oboInOwl:source "ncithesaurus:Left_Pulmonary_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009030 ; owl:annotatedTarget "A vein that returns oxygenated blood from the left lung to the left atrium of the heart[ncithesaurus:Left_Pulmonary_Vein]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009030 ; owl:annotatedTarget "EMAPA:37165" . [] oboInOwl:source "ncithesaurus:Left_Pulmonary_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009030 ; owl:annotatedTarget "UMLS:C0226670" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:11412894" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009032 ; owl:annotatedTarget "Vein that drains right lung and returns blood to the heart." . [] oboInOwl:source "ncithesaurus:Right_Pulmonary_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009032 ; owl:annotatedTarget "A vein that returns oxygenated blood from the right lung to the left atrium of the heart[ncithesaurus:Right_Pulmonary_Vein]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009032 ; owl:annotatedTarget "EMAPA:37379" . [] oboInOwl:source "ncithesaurus:Right_Pulmonary_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009032 ; owl:annotatedTarget "UMLS:C0226669" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009039 ; owl:annotatedTarget _:genid148048 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009039 ; owl:annotatedTarget "A germinal center that is located in a lymph node." . [] oboInOwl:hasDbXref "BTO:0003671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0009039 ; owl:annotatedTarget "germinal center" . [] oboInOwl:hasDbXref "Wikipedia:Prostatic_venous_plexus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009042 ; owl:annotatedTarget "The prostatic veins form a well-marked prostatic plexus which lies partly in the fascial sheath of the prostate and partly between the sheath and the prostatic capsule. It communicates with the pudendal and vesical plexuses." . [] oboInOwl:hasDbXref "Wikipedia:Prostatic_venous_plexus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009042 ; owl:annotatedTarget "plexus venosus prostaticus" . [] oboInOwl:hasDbXref "FMA:29711" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009042 ; owl:annotatedTarget "pudendal venous plexus" . [] oboInOwl:hasDbXref "BTO:0004733" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009097 ; owl:annotatedTarget "An organism containing a developing embryo, fetus, or unborn offspring within the body." . [] oboInOwl:hasDbXref "BTO:0004733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009097 ; owl:annotatedTarget "gravid" . [] oboInOwl:hasDbXref "BTO:0004733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009097 ; owl:annotatedTarget "pregnant adult" . [] oboInOwl:hasDbXref "BTO:0004733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009097 ; owl:annotatedTarget "pregnant adult stage" . [] oboInOwl:hasDbXref "BTO:0004733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009097 ; owl:annotatedTarget "pregnant stage" . _:genid146329 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000995 [ a owl:Restriction ; owl:onProperty obo:RO_0001015 ; owl:someValuesFrom obo:UBERON_0000922 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/gravid+uterus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009098 ; owl:annotatedTarget "The uterus in pregnancy." . [] oboInOwl:source "ncithesaurus:Pregnant_Uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009098 ; owl:annotatedTarget "UMLS:C1514389" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009114 ; owl:annotatedTarget "A mature thymus that is entirely part of the cervical region." . [] oboInOwl:source "MA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009115 ; owl:annotatedTarget _:genid148086 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009115 ; owl:annotatedTarget "A mature thymus that is entirely part of thoracic region." . [] oboInOwl:hasDbXref "http://www.medterms.com/script/main/art.asp?articlekey=8981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009117 ; owl:annotatedTarget "A gonad prior to differentiating into a definitive testis or ovary." . [] oboInOwl:source "ncithesaurus:Indifferent_Gonad" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009117 ; owl:annotatedTarget "UMLS:C1512703" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009122 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009122 ; owl:annotatedTarget _:genid148093 . [] oboInOwl:hasDbXref "http://www.ncbi.nlm.nih.gov/books/NBK53175/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009122 ; owl:annotatedTarget "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary." . [] oboInOwl:hasDbXref "ZFA:0001198" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009122 ; owl:annotatedTarget "pituitary placode" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget obo:UBERON_0003078 . [] oboInOwl:hasDbXref "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "Rostralmost epibranchial placode. Associated with 1st branchial cleft." . [] oboInOwl:hasDbXref "EHDAA2:0004206" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "epibranchial placode 1" . [] oboInOwl:hasDbXref "XAO:0004211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "facial epibranchial placode" . [] oboInOwl:hasDbXref "ZFA:0001295" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "facial placode" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "hyoid VII placode" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009124 ; owl:annotatedTarget "hyoid placode" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget obo:UBERON_0003078 . [] oboInOwl:hasDbXref "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget "Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft." . [] oboInOwl:hasDbXref "EHDAA2:0004207" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget "epibranchial placode 2" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget "glossopharyngeal IX placode" . [] oboInOwl:hasDbXref "XAO:0004212" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget "glossopharyngeal epibranchial placode" . [] oboInOwl:hasDbXref "ISBN:0471888893", "ZFA:0001296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009125 ; owl:annotatedTarget "glossopharyngeal placode" . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget obo:UBERON_0003078 . [] oboInOwl:hasDbXref "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "Caudalmost epibranchial placode. Associated with 3rd branchial cleft." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002009 ; owl:annotatedTarget obo:CL_0002032 . [] oboInOwl:hasDbXref "EHDAA2:0004208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "epibranchial placode 3" . [] oboInOwl:hasDbXref "XAO:0004213" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "nodose placode" . [] oboInOwl:hasDbXref "XAO:0004213" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "nodose placodes" . _:genid146373 oboInOwl:hasDbXref "XAO:0004213" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "vagal epibranchial placode" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 . [] oboInOwl:hasDbXref "XAO:0004213" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "vagal epibranchial placodes" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "vagal X placode" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009126 ; owl:annotatedTarget "vagal placode" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002009 ; owl:annotatedTarget "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009127 ; owl:annotatedTarget obo:UBERON_0001714 . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009127 ; owl:annotatedTarget _:genid148124 . [] oboInOwl:hasDbXref "PMID:20133851", "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009127 ; owl:annotatedTarget "Cranial ganglion which develops from an epibranchial placode." . [] oboInOwl:hasDbXref "ZFA:0001555" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009127 ; owl:annotatedTarget "epibranchial ganglia" . (obo:UBERON_0002165 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002078 ] ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget _:genid148133 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget _:genid148135 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget "Endocardium that is part of the right atrium." . [] oboInOwl:hasDbXref "FMA:7281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget "endocardium of right atrium" . [] oboInOwl:hasDbXref "FMA:7281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget "right atrial endocardium" . [] oboInOwl:hasDbXref "VHOG:0001228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009129 ; owl:annotatedTarget "right atrium endocardial tissue" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009132 ; owl:annotatedTarget _:genid148141 . [] oboInOwl:source "wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009132 ; owl:annotatedTarget _:genid148143 . [] oboInOwl:source "wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009132 ; owl:annotatedTarget _:genid148145 . [] oboInOwl:hasDbXref "Wikipedia:Fibularis_muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009132 ; owl:annotatedTarget "One of a group of three muscles fibularis (peronæus) longus, brevis, and tertius originating on the fibula and inserting on the metatarsals." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:16341241" . _:genid146400 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001179, obo:UBERON_0003623 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget obo:UBERON_0002050 . [] oboInOwl:hasDbXref "Wikipedia:Pleuroperitoneal", "http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000757" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pleuroperitoneal_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget "UMLS:C1283968" . [] oboInOwl:hasDbXref "VHOG:0000757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget "pleuroperitoneal fold" . [] oboInOwl:hasDbXref "EHDAA2:0001483" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009133 ; owl:annotatedTarget "pleuroperitoneal membranes" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009139 ; owl:annotatedTarget "A posterior cardinal vein that is in_the_right_side_of a multicellular organism." . [] oboInOwl:hasDbXref "EHDAA2:0004536" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009139 ; owl:annotatedTarget "posterior cardinal vein right" . _:genid146415 oboInOwl:hasDbXref "FMA:70315" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009139 ; owl:annotatedTarget "right postcardinal vein" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003624 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009141 ; owl:annotatedTarget _:genid148168 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009141 ; owl:annotatedTarget "A vein that is part of a craniocervical region." . [] oboInOwl:hasDbXref "EHDAA2:0004542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009141 ; owl:annotatedTarget "head and neck veins" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009142 ; owl:annotatedTarget _:genid148173 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009142 ; owl:annotatedTarget "Sum total of mesenchyme in the embryo." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009145 ; owl:annotatedTarget _:genid148177 . [] oboInOwl:hasDbXref "EMAPA:16549" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009145 ; owl:annotatedTarget "pharyngeal region" . (obo:UBERON_0015060 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009191 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009191 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009191 ; owl:annotatedTarget _:genid148186 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009191 ; owl:annotatedTarget _:genid148188 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009191 ; owl:annotatedTarget "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009193 ; owl:annotatedTarget obo:UBERON_0005863 . _:genid146444 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009193 ; owl:annotatedTarget _:genid148196 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003631 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009193 ; owl:annotatedTarget "A sphenoid endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0001888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009193 ; owl:annotatedTarget "sphenoid bone cartilage condensation" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009196 ; owl:annotatedTarget obo:UBERON_0004176 . [] oboInOwl:hasDbXref "GO:0097094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009198 ; owl:annotatedTarget "Any suture between cranial and/or facial bones." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009198 ; owl:annotatedTarget "joint of the skull bones" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009198 ; owl:annotatedTarget "articulation of skull bones" . _:genid146459 a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:UBERON_0003462 ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003632 . [] oboInOwl:notes "between two adjacent facial bones" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009199 ; owl:annotatedTarget _:genid148216 . [] oboInOwl:hasDbXref "GO:0097096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009199 ; owl:annotatedTarget "Any suture between facial bones." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009200 ; owl:annotatedTarget "The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." . _:genid146472 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113, obo:UBERON_0003633 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009201 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "GO:0072176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009201 ; owl:annotatedTarget "A nephric duct is a tube that drains a primitive kidney[GO]." . [] oboInOwl:notes "between both nasal bones" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget _:genid148234 . [] oboInOwl:hasDbXref "Wikipedia:Internasal_suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget "A suture joining the nasal bones." . [] oboInOwl:hasDbXref "GO:0097097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget "nasal suture" . [] oboInOwl:hasDbXref "FMA:52959" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget "internasal suture of skull" . [] oboInOwl:hasDbXref "Wikipedia:Internasal_suture" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget "sutura internasalis" . [] oboInOwl:hasDbXref "Wikipedia:Internasal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009203 ; owl:annotatedTarget "sutura internasalis" . _:genid146485 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004068 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003634 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009204 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009204 ; owl:annotatedTarget _:genid148246 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009204 ; owl:annotatedTarget _:genid148248 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0009204 ; owl:annotatedTarget obo:UBERON_0009205 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009204 ; owl:annotatedTarget "Mesenchyme that is part of a medial nasal prominence." . _:genid146498 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009205 ; owl:annotatedTarget _:genid148256 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003635 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009205 ; owl:annotatedTarget "Mesenchyme that is part of a lateral nasal prominence." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:24287311" . [] oboInOwl:hasDbXref "EMAPA:16807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009205 ; owl:annotatedTarget "mesenchyme of latero-nasal process" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009206 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009206 ; owl:annotatedTarget _:genid148265 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009206 ; owl:annotatedTarget _:genid148267 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009206 ; owl:annotatedTarget "An ectoderm that is part of a lateral nasal prominence." . [] oboInOwl:hasDbXref "EMAPA:16806" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009206 ; owl:annotatedTarget "ectoderm of latero-nasal process" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009210 ; owl:annotatedTarget _:genid148271 . [] oboInOwl:hasDbXref "http://musom.marshall.edu/anatomy/grosshom/z_devbranc.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009210 ; owl:annotatedTarget "A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001427" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0124020603 Kaufman MH, Bard JBL, The anatomical basis of mouse development (1999) p.72", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0009210 ; owl:annotatedTarget "In all vertebrates, the endodermal epithelium lining each pouch contacts the surface ectoderm of the clefts to form a series of bilayered branchial membranes, that break down in fish to form the gill openings.[well established][VHOG]" . [] oboInOwl:source "ncithesaurus:Pharyngeal_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009210 ; owl:annotatedTarget "UMLS:C1519040" . [] oboInOwl:hasDbXref "EMAPA:32749" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009210 ; owl:annotatedTarget "branchial arch membrane" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget _:genid148281 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget "A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch." . [] oboInOwl:hasDbXref "EMAPA:16992" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget "1st branchial membrane" . [] oboInOwl:hasDbXref "VHOG:0001427" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget "1st pharyngeal membrane" . [] oboInOwl:hasDbXref "EMAPA:17281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget "future tympanic membrane" . [] oboInOwl:hasDbXref "ISBN:1416037055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009213 ; owl:annotatedTarget "tympanic membrane primordium" . [] oboInOwl:hasDbXref "VSAO:0000183", "VSAO:curator", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009291 ; owl:annotatedTarget "Cartilaginous form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." . [] oboInOwl:hasDbXref "PMID:11746457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009291 ; owl:annotatedTarget "postcaudal cartilaginous centrum" . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009292 ; owl:annotatedTarget "medial or lateral; in EHDAA2 also frontonasal or intermaxillary" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget _:genid148298 . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/dorsum-of-tongue.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget "The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis)." . [] oboInOwl:source "ncithesaurus:Dorsum_of_the_Tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget "UMLS:C0226952" . [] oboInOwl:hasDbXref "FMA:54651" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget "dorsal tongue" . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/dorsum-of-tongue.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget "dorsum linguae" . [] oboInOwl:hasDbXref "FMA:54651" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009471 ; owl:annotatedTarget "tongue dorsum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget _:genid148305 . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "The axilla is the area directly under the joint where the forelimb connects to the shoulder." . [] oboInOwl:source "ncithesaurus:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "UMLS:C0004454" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "arm pit" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "armpit" . [] oboInOwl:hasDbXref "FMA:24864" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "axillary region" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "regio axillaris" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "armpits" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "axilla" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "axillae" . _:genid146551 oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "axillary region" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001310 . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "oxter" . [] oboInOwl:hasDbXref "Wikipedia:Axilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009472 ; owl:annotatedTarget "underarm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009477 ; owl:annotatedTarget "Mesenchyme that is part of a otic placode." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009479 ; owl:annotatedTarget "An ectoderm that is part of a buccopharyngeal membrane." . _:genid146569 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009480 ; owl:annotatedTarget "An endoderm that is part of a buccopharyngeal membrane." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009482 ; owl:annotatedTarget "Mesenchyme that is part of a foregut-midgut junction." . (obo:UBERON_0002095 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009483 ; owl:annotatedTarget "A mesentery that is part of a foregut-midgut junction." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000430" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0009483 ; owl:annotatedTarget "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000430" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009483 ; owl:annotatedTarget "foregut-midgut junction mesentery" . _:genid146584 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002539, obo:UBERON_0011921 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget _:genid148353 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget "A portion of mesenchymal tissue associated with an individual pharyngeal arch." . [] oboInOwl:source "MP:0011262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget "this represents a part of the entire arch mesenchyme (UBERON:0010046), and is therefore a superclass of the individual arch mesenchyme classes. Alternate definition: primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures." . [] oboInOwl:hasDbXref "MP:0011262" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget "branchial arch mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009494 ; owl:annotatedTarget "pharyngeal arch mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009497 ; owl:annotatedTarget _:genid148363 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009497 ; owl:annotatedTarget _:genid148365 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009497 ; owl:annotatedTarget "An epithelium that is part of a foregut-midgut junction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:25308664" . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget _:genid148372 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget _:genid148374 . [] oboInOwl:hasDbXref "PMID:3794595", "XAO:0004474", "XAO:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget "Anatomical region that surrounds the otic vesicle." . [] oboInOwl:hasDbXref "EHDAA2:0001343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget "otocyst associated mesenchyme" . [] oboInOwl:hasDbXref "EMAPA:16670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget "otocyst mesenchyme" . [] oboInOwl:hasDbXref "XAO:0004474" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009500 ; owl:annotatedTarget "periotic region" . [] oboInOwl:hasDbXref "MP:0011266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009501 ; owl:annotatedTarget "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head." . [] oboInOwl:hasDbXref "MP:0011266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009501 ; owl:annotatedTarget "frontonasal mesenchyme" . [] oboInOwl:hasDbXref "MP:0011266" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009501 ; owl:annotatedTarget "naso-frontal mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009503 ; owl:annotatedTarget "Mesenchyme that is part of a developing hindgut." . [] oboInOwl:hasDbXref "EHDAA2:0000780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009503 ; owl:annotatedTarget "hindgut associated mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009505 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009505 ; owl:annotatedTarget "Mesenchyme that is part of a developing trachea." . [] oboInOwl:hasDbXref "EHDAA2:0002067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009505 ; owl:annotatedTarget "trachea associated mesenchyme" . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget obo:UBERON_0007524 . _:genid146637 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget _:genid148407 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002358 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget _:genid148409 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget "Mesenchyme that is part of a developing middle ear." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget "Also 1st arch maxillary mesenchyme in EHDAA2" . [] oboInOwl:hasDbXref "EHDAA2:0001182" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009506 ; owl:annotatedTarget "middle ear associated mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009521 ; owl:annotatedTarget "An endoderm that is part of a anal region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009522 ; owl:annotatedTarget "An epithelium that is part of a lateral lingual swelling." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009523 ; owl:annotatedTarget _:genid148430 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009523 ; owl:annotatedTarget "Mesenchyme that is part of a handplate." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009523 ; owl:annotatedTarget "We group two EMAPA classes here but these may need to be separated" . [] oboInOwl:hasDbXref "EHDAA2:0000731" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009523 ; owl:annotatedTarget "handplate mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009526 ; owl:annotatedTarget "Mesenchyme that is part of a maxillary prominence." . [] oboInOwl:hasDbXref "EMAPA:17361" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009526 ; owl:annotatedTarget "mesenchyme of maxillary process" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009526 ; owl:annotatedTarget "mesenchyme of maxillary prominence" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009536 ; owl:annotatedTarget "A vascular plexus that is part of a left lung." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009537 ; owl:annotatedTarget "A vascular plexus that is part of a right lung." . _:genid146679 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006297 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009538 ; owl:annotatedTarget "Mesenchyme that is part of a sublingual gland primordium." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009539 ; owl:annotatedTarget "Mesenchyme that is part of a submandibular gland primordium." . [] oboInOwl:hasDbXref "EMAPA:17757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009539 ; owl:annotatedTarget "submaxillary gland primordium mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009548 ; owl:annotatedTarget "A hepatic sinusoid that is part of a left lobe of liver." . [] oboInOwl:hasDbXref "VHOG:0000709" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009548 ; owl:annotatedTarget "left lobe hepatic sinusoids" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:25451949" . _:genid146701 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001114, obo:UBERON_0010377 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009549 ; owl:annotatedTarget "A hepatic sinusoid that is part of a right lobe of liver." . [] oboInOwl:hasDbXref "VHOG:0000710" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009549 ; owl:annotatedTarget "right lobe hepatic sinusoids" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009550 ; owl:annotatedTarget "An endoderm that is part of a foregut-midgut junction." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009551 ; owl:annotatedTarget _:genid148484 . [] oboInOwl:hasDbXref "DOI:10.1038/nature10346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009551 ; owl:annotatedTarget "A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium)." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009551 ; owl:annotatedTarget "digit tip" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009551 ; owl:annotatedTarget "distal digit segment" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009551 ; owl:annotatedTarget "tip of digit" . (obo:UBERON_0009551 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002389 ] ) . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "A segment of the manual digit containing the distal phalanx." . [] oboInOwl:hasDbXref "DOI:10.1038/nature10346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "finger digit tip" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "finger distal segment" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "finger tip" . [] oboInOwl:hasDbXref "HP:0001211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "fingertip" . [] oboInOwl:hasDbXref "DOI:10.1038/nature10346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009552 ; owl:annotatedTarget "forelimb digit tip" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "A segment of the pedal digit containing the distal phalanx. Note this class represents a digit segment and thus includes tissues in addition to bone." . [] oboInOwl:hasDbXref "DOI:10.1038/nature10346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "hindlimb digit tip" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "tip of toe" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002010 ; owl:annotatedTarget obo:CL_0002031 . [] oboInOwl:hasDbXref "DOI:10.1038/nature10346" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "toe digit tip" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "toe distal segment" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "P3 segment of pedal digit" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009553 ; owl:annotatedTarget "distalmost part of toe" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002010 ; owl:annotatedTarget "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget "A skeletal joint that connects a mesopodium bone and connects a proximal phalanx." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget "metacarpo-tarsophalangeal joint" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget "metapodial-phalangeal joint" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget "metapodium-phalanx joint" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "Wikipedia:Fetlock", "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009559 ; owl:annotatedTarget "fetlock" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009564 ; owl:annotatedTarget _:genid148532 . [] oboInOwl:source "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009564 ; owl:annotatedTarget _:genid148534 . _:genid146760 oboInOwl:hasDbXref "PMID:11710767" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009564 ; owl:annotatedTarget "A nail, hoof or claw." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007811 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget _:genid148541 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget _:genid148543 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "A nail that is part of a manual digit." . [] oboInOwl:source "ncithesaurus:Fingernail" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "UMLS:C0222001" . [] oboInOwl:hasDbXref "FMA:54327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "finger nail" . [] oboInOwl:hasDbXref "FMA:54327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "fingernail" . [] oboInOwl:hasDbXref "FMA:54327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "nail of finger" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "claw of hand" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "claw of manus" . [] oboInOwl:hasDbXref "EMAPA:35349" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "forelimb digit claw" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "manual claw" . [] oboInOwl:hasDbXref "FMA:54327" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009565 ; owl:annotatedTarget "nail plate of finger" . (obo:UBERON_0000009 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009566 ; owl:annotatedTarget _:genid148559 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009566 ; owl:annotatedTarget "A submucosa that is part of a intestine." . [] oboInOwl:hasDbXref "FMA:15696" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009566 ; owl:annotatedTarget "submucosa of intestine" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget _:genid148567 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget _:genid148569 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "A nail that is part of a pedal digit." . [] oboInOwl:source "ncithesaurus:Toe_Nail" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "UMLS:C0222007" . [] oboInOwl:hasDbXref "FMA:54328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "nail of toe" . [] oboInOwl:hasDbXref "FMA:54328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "toe nail" . [] oboInOwl:hasDbXref "FMA:54328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "toenail" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "claw of foot" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "claw of pes" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "claw of toe" . [] oboInOwl:hasDbXref "EMAPA:36457" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "hindlimb claw" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "hindlimb digit claw" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:25522988" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "pedal claw" . [] oboInOwl:hasDbXref "FMA:54328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009567 ; owl:annotatedTarget "nail plate of toe" . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000612" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Duellman_and_Trueb_1994" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" . [] oboInOwl:hasDbXref "FMA:72066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "thoracolumbar vertebrae set" . [] oboInOwl:hasDbXref "AAO:0000612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "presacral region" . [] oboInOwl:hasDbXref "AAO:0000612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "thoracolumbar region" . [] oboInOwl:hasDbXref "AAO:0000612" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009568 ; owl:annotatedTarget "trunk region" . [] oboInOwl:hasDbXref "FMA:25054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009569 ; owl:annotatedTarget "region of trunk" . [] oboInOwl:hasDbXref "FMA:25054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009569 ; owl:annotatedTarget "trunk subdivision" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009570 ; owl:annotatedTarget "A sulcus limitans of neural tube that is part of a future spinal cord." . [] oboInOwl:hasDbXref "EHDAA2:0001265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009570 ; owl:annotatedTarget "spinal cord lateral wall sulcus limitans" . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009572 ; owl:annotatedTarget _:genid148609 . [] oboInOwl:hasDbXref "Wikipedia:Central_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009572 ; owl:annotatedTarget "A cerebrospinal fluid-filled space that runs longitudinally through the length of the entire spinal cord. The central canal is contiguous with the ventricular system of the brain. The central canal represents the adult remainder of the neural tube." . [] oboInOwl:hasDbXref "FMA:242845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009572 ; owl:annotatedTarget "cavity of central canal of spinal cord" . _:genid146833 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009572 ; owl:annotatedTarget "central canal lumen" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001705 . [] oboInOwl:hasDbXref "EMAPA:25042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009572 ; owl:annotatedTarget "spinal cord lumen" . _:genid146839 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009576 ; owl:annotatedTarget _:genid148621 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009576 ; owl:annotatedTarget "A sulcus limitans of neural tube that is part of a future medulla oblongata." . _:genid146841 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005478 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010092 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009577 ; owl:annotatedTarget "A sulcus limitans of neural tube that is part of a future metencephalon." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009578 ; owl:annotatedTarget "A sulcus limitans of neural tube that is part of a future myelencephalon." . _:genid146851 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004061 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006222 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 . [] oboInOwl:hasDbXref "VHOG:0000912" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009580 ; owl:annotatedTarget "mantle layer lateral wall diencephalon" . _:genid146858 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001464, obo:UBERON_0009616 . [] oboInOwl:hasDbXref "VHOG:0000910" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009581 ; owl:annotatedTarget "mantle layer lateral wall midbrain" . [] oboInOwl:hasDbXref "VHOG:0000910" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009581 ; owl:annotatedTarget "mantle layer lateral wall mesencephalon" . [] oboInOwl:hasDbXref "VHOG:0000911" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009583 ; owl:annotatedTarget "mantle layer lateral wall spinal cord" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002011 ; owl:annotatedTarget obo:CL_0002009 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009584 ; owl:annotatedTarget _:genid148654 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009584 ; owl:annotatedTarget "Mesenchyme that is part of a 1st arch mandibular component." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009584 ; owl:annotatedTarget "mesenchymal region of mandibular component of first pharyngeal arch" . [] oboInOwl:hasDbXref "EMAPA:16385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009584 ; owl:annotatedTarget "mesenchyme of mandibular component" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009602 ; owl:annotatedTarget "Mesenchyme that is part of a developing left lung." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002011 ; owl:annotatedTarget "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." . [] oboInOwl:hasDbXref "EMAPA:17654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009602 ; owl:annotatedTarget "left lung mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009603 ; owl:annotatedTarget "Mesenchyme that is part of a developing right lung." . [] oboInOwl:hasDbXref "EMAPA:17662" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009603 ; owl:annotatedTarget "right lung mesenchyme" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009610 ; owl:annotatedTarget _:genid148671 . _:genid146891 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009610 ; owl:annotatedTarget _:genid148676 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000915 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009610 ; owl:annotatedTarget "A neural plate that develops_from a future forebrain." . (obo:UBERON_0003075 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009616 ] ) . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009611 ; owl:annotatedTarget _:genid148679 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009611 ; owl:annotatedTarget _:genid148684 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009611 ; owl:annotatedTarget "A neural plate that develops_from a presumptive midbrain." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:25658343" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009614 ; owl:annotatedTarget _:genid148687 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009614 ; owl:annotatedTarget _:genid148692 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009614 ; owl:annotatedTarget "A neural plate that develops_from a presumptive hindbrain." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009615 ; owl:annotatedTarget _:genid148695 . [] oboInOwl:notes "https://github.com/obophenotype/uberon/issues/438" ; oboInOwl:source "Bgee:AN" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009615 ; owl:annotatedTarget _:genid148697 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009615 ; owl:annotatedTarget "MHB neural plate" . _:genid146908 oboInOwl:hasDbXref "ZFA:0007044" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009615 ; owl:annotatedTarget "midbrain-hindbrain boundary neural plate" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005462 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget _:genid148705 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget _:genid148708 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget "A presumptive structure that has the potential to develop into a midbrain." . _:genid146917 oboInOwl:hasDbXref "ZFA:0000148" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget "presumptive mesencephalon" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008231 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget "early midbrain" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget "future midbrain" . [] oboInOwl:hasDbXref "EHDAA2:0000615" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009616 ; owl:annotatedTarget "mesencephalon" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget _:genid148716 . [] oboInOwl:hasDbXref "PMID:21610022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "cephalic paraxial mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "cephalic paraxial mesoderm" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "cranial paraxial mesenchyme" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "cranial paraxial mesoderm" . [] oboInOwl:hasDbXref "EHDAA2:0000736", "https://github.com/obophenotype/uberon/issues/30" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009617 ; owl:annotatedTarget "head paraxial mesenchyme" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009618 ; owl:annotatedTarget _:genid148725 . [] oboInOwl:hasDbXref "EHDAA2:0002094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009618 ; owl:annotatedTarget "trunk and cervical paraxial mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/30" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009618 ; owl:annotatedTarget "trunk paraxial mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009621 ; owl:annotatedTarget "A somite that is part of a tail." . _:genid146938 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001780 _:genid146940 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001758 . _:genid146940 a owl:Restriction ; owl:onProperty obo:RO_0002202, core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0002342, obo:UBERON_0002792 . _:genid146942 oboInOwl:hasDbXref "Wikipedia:Lumbar_nerves" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009624 ; owl:annotatedTarget "The lumbar nerves are the five spinal nerves emerging from the lumbar vertebrae. They are divided into posterior and anterior divisions." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0008969 . [] oboInOwl:source "ncithesaurus:Lumbar_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009624 ; owl:annotatedTarget "UMLS:C0228897" . [] oboInOwl:hasDbXref "FMA:5861" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009624 ; owl:annotatedTarget "lumbar spinal nerve" . [] oboInOwl:hasDbXref "FMA:5861", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009624 ; owl:annotatedTarget "nervus lumbalis" . [] oboInOwl:hasDbXref "Wikipedia:Lumbar_nerves" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009624 ; owl:annotatedTarget "nervi lumbales" . [] oboInOwl:hasDbXref "Wikipedia:Sacral_nerves" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009625 ; owl:annotatedTarget "The five sacral nerves emerge from the sacrum. Although the vertebral components of the sacrum are fused into a single bone, the sacral vertebrae are still used to number the sacral nerves. Posteriorly, they emerge from the posterior sacral foramina, and form the posterior branches of sacral nerves. Anteriorly, they emerge from the anterior sacral foramina, and contribute to the sacral plexus (S1-S4) and coccygeal plexus." . [] oboInOwl:source "ncithesaurus:Sacral_Nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009625 ; owl:annotatedTarget "UMLS:C0228922" . [] oboInOwl:hasDbXref "FMA:5862", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009625 ; owl:annotatedTarget "nervus sacralis" . [] oboInOwl:hasDbXref "FMA:5862" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009625 ; owl:annotatedTarget "sacral spinal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Sacral_nerves" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009625 ; owl:annotatedTarget "nervi sacrales" . [] oboInOwl:hasDbXref "ISBN:1588903958", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009636 ; owl:annotatedTarget "Chondrocranium chondrification center that that forms anterior body of sphenoid, containing the sella turcica and posterior body of sphenoid." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget _:genid148753 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget _:genid148755 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget _:genid148757 . [] oboInOwl:source "ISBN:1588903958" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget _:genid148759 . [] oboInOwl:source "ISBN:1588903958" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget _:genid148761 . [] oboInOwl:hasDbXref "Wikipedia:Body_of_sphenoid_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "The body of the sphenoid bone, more or less cubical in shape, is hollowed out in its interior to form two large cavities, the sphenoidal air sinuses, which are separated from each other by a septum." . [] oboInOwl:hasDbXref "FMA:52867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "body of sphenoidal bone" . [] oboInOwl:hasDbXref "FMA:52867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "central body of sphenoid" . [] oboInOwl:hasDbXref "FMA:52867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "corpus (os sphenoidale)" . [] oboInOwl:hasDbXref "FMA:52867" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "sphenoid body" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_sphenoid_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009639 ; owl:annotatedTarget "corpus ossis sphenoidalis" . [] oboInOwl:hasDbXref "ISBN:1588903958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009640 ; owl:annotatedTarget "Forms around the developing pituitary, and together with prechordal cartilages creates body of sphenoid bone." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009644 ; owl:annotatedTarget obo:UBERON_0003571 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "A sympathetic nerve trunk that is part of a lower back." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "EMAPA:37655" . [] oboInOwl:source "ncithesaurus:Lumbar_Sympathetic_Nerve_Trunk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "UMLS:C1708762" . [] oboInOwl:hasDbXref "FMA:6263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "lumbar sympathetic trunk" . [] oboInOwl:hasDbXref "FMA:6263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "lumbar part of sympathetic trunk" . [] oboInOwl:hasDbXref "FMA:6263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009646 ; owl:annotatedTarget "lumbar sympathetic chain" . _:genid146984 oboInOwl:hasDbXref "PMID:11237469", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009647 ; owl:annotatedTarget "One of the two epithelia which make up the tympanic membrane (along with the fibrous layer)." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000989 . [] oboInOwl:source "ncithesaurus:Tympanic_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009647 ; owl:annotatedTarget "UMLS:C1711401" . [] oboInOwl:hasDbXref "MA:0001224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009647 ; owl:annotatedTarget "tympanic epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009648 ; owl:annotatedTarget "An eyelid connective tissue that is part of a hypodermis." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009648 ; owl:annotatedTarget "EMAPA:37533" . [] oboInOwl:source "ncithesaurus:Eyelid_Subcutaneous_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009648 ; owl:annotatedTarget "UMLS:C1707991" . [] oboInOwl:hasDbXref "FMA:63975" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009648 ; owl:annotatedTarget "superficial fascia of eyelid" . (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 ] ) . ( ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:25977713" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget _:genid148801 . _:genid147001 oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget _:genid148803 ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0007315 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget "A basement membrane that is part of a nephron tubule." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget "EMAPA:37490" . [] oboInOwl:source "ncithesaurus:Renal_Tubule_Basement_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget "UMLS:C1709901" . [] oboInOwl:hasDbXref "MA:0001680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget "kidney tubule basement membrane" . [] oboInOwl:hasDbXref "MA:0001680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009651 ; owl:annotatedTarget "renal tubule basement membrane" . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget _:genid148814 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget "A basement membrane that is part of a bronchus." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget "MA classifies as type of connective tissue: https://github.com/obophenotype/mouse-anatomy-ontology/issues/108" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget "EMAPA:37809" . _:genid147015 oboInOwl:source "ncithesaurus:Bronchus_Basement_Membrane" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget "UMLS:C1707051" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009652 ; owl:annotatedTarget "bronchial basement membrane" . _:genid147017 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005769 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003126 ] ) ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0007315 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002012 ; owl:annotatedTarget obo:CL_0000547 . [] oboInOwl:is_inferred "true" ; oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009653 ; owl:annotatedTarget _:genid148825 . [] oboInOwl:source "MA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009653 ; owl:annotatedTarget _:genid148827 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009653 ; owl:annotatedTarget "A basement membrane that is part of a trachea." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009653 ; owl:annotatedTarget "EMAPA:37552" . [] oboInOwl:source "ncithesaurus:Trachea_Basement_Membrane" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009653 ; owl:annotatedTarget "UMLS:C1710455" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009654 ; owl:annotatedTarget obo:UBERON_0001637 . [] oboInOwl:hasDbXref "ncithesaurus:Alveolar_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009654 ; owl:annotatedTarget "A branch of the maxillary artery that is found in the gingiva, premolars, and molars." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002012 ; owl:annotatedTarget "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009654 ; owl:annotatedTarget "EMAPA:37069" . [] oboInOwl:source "ncithesaurus:Alveolar_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009654 ; owl:annotatedTarget "UMLS:C1706783" . [] oboInOwl:hasDbXref "ncithesaurus:Auricular_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009655 ; owl:annotatedTarget "An artery that supplies oxygenated blood to the ear." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009655 ; owl:annotatedTarget "EMAPA:37072" . [] oboInOwl:source "ncithesaurus:Auricular_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009655 ; owl:annotatedTarget "UMLS:C1706858" . [] oboInOwl:hasDbXref "MA:0001987" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0009657 ; owl:annotatedTarget "labial artery" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009657 ; owl:annotatedTarget "EMAPA:37092" . [] oboInOwl:source "ncithesaurus:Labial_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009657 ; owl:annotatedTarget "UMLS:C1708633" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009661 ; owl:annotatedTarget "Nucleus located in the midbrain." . ( ) . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009662 ; owl:annotatedTarget "Nucleus located within the hindbrain." . (obo:UBERON_0002308 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009663 ; owl:annotatedTarget "A nucleus of brain that is part of a telencephalon." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009664 ; owl:annotatedTarget _:genid148867 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009664 ; owl:annotatedTarget "peritoneal cavity mesentary" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009664 ; owl:annotatedTarget "peritoneal mesentary" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009668 ; owl:annotatedTarget _:genid148871 . [] oboInOwl:hasDbXref "Wikipedia:Ventral_mesentery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009668 ; owl:annotatedTarget "Ventral mesentery is the part of the peritoneum closest to the navel." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009669 ; owl:annotatedTarget "An anatomical space that surrounded_by a embryonic cloaca." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009670 ; owl:annotatedTarget _:genid148886 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009670 ; owl:annotatedTarget _:genid148888 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009670 ; owl:annotatedTarget "An anatomical space that surrounded_by a rectum." . [] oboInOwl:hasDbXref "FMA:14598" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009670 ; owl:annotatedTarget "lumen of rectum" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009676 ; owl:annotatedTarget _:genid148892 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009676 ; owl:annotatedTarget _:genid148894 . _:genid147084 oboInOwl:hasDbXref "EHDAA2:0001981" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009676 ; owl:annotatedTarget "early telencephalic vesicle" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008344 . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009678 ; owl:annotatedTarget "Anatomical cluster consisting of adjacent teeth constituting a row." . [] oboInOwl:hasDbXref "FMA:59415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009678 ; owl:annotatedTarget "dental arcade" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009678 ; owl:annotatedTarget "row of teeth" . _:genid147092 oboInOwl:hasDbXref "ZFA:0001642" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009678 ; owl:annotatedTarget "tooth rows" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008342 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "A tooth row that is part of a skeleton of lower jaw." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "arcus dentalis inferior" . [] oboInOwl:hasDbXref "FMA:55635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "lower dental arcade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:4696527" . [] oboInOwl:hasDbXref "EHDAA2:0001029" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "lower jaw teeth" . [] oboInOwl:hasDbXref "FMA:55635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "set of all lower teeth" . [] oboInOwl:hasDbXref "FMA:55635" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009679 ; owl:annotatedTarget "mandibular dental arcade" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "A tooth row that is part of a skeleton of upper jaw." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "arcus dentalis superior" . [] oboInOwl:hasDbXref "FMA:55634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "set of all upper teeth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002013 ; owl:annotatedTarget obo:CL_0000549 . [] oboInOwl:hasDbXref "FMA:55634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "upper dental arcade" . _:genid147111 oboInOwl:hasDbXref "EHDAA2:0002129" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "upper jaw teeth" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006956 . [] oboInOwl:hasDbXref "FMA:55634" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009680 ; owl:annotatedTarget "maxillary dental arcade" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget obo:UBERON_0005082 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget _:genid148931 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002013 ; owl:annotatedTarget "A basophilic erythroblast that is GlyA-positive." . [] oboInOwl:source "EHDAA2/Kardong" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget _:genid148933 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget "An organ cavity that is part of a pharyngotympanic tube." . [] oboInOwl:hasDbXref "EHDAA2:0004118" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget "auditory tube lumen" . [] oboInOwl:hasDbXref "FMA:60079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget "lumen of auditory tube" . [] oboInOwl:hasDbXref "FMA:60079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget "lumen of eustachian tube" . [] oboInOwl:hasDbXref "FMA:60079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009692 ; owl:annotatedTarget "pharyngotympanic tube lumen" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget _:genid148944 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget _:genid148946 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget _:genid148948 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget "An epithelium that is part of a hypopharynx." . [] oboInOwl:hasDbXref "FMA:62454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget "epithelium of laryngeal pharynx" . [] oboInOwl:hasDbXref "FMA:62454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009695 ; owl:annotatedTarget "laryngopharynx epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009708 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009708 ; owl:annotatedTarget _:genid148954 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009708 ; owl:annotatedTarget _:genid148956 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009708 ; owl:annotatedTarget _:genid148958 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009709 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009709 ; owl:annotatedTarget _:genid148961 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009709 ; owl:annotatedTarget _:genid148963 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009709 ; owl:annotatedTarget _:genid148965 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget _:genid148971 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget _:genid148973 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "Any endocardium that is part of the right ventricle of the heart." . [] oboInOwl:source "FMA:9536" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "Endocardium of ventricle which is continuous tricuspid valve, pulmonary valve and with the tunica intima of the pulmonary trunk." . [] oboInOwl:hasDbXref "VHOG:0001235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "right ventricle endocardium" . [] oboInOwl:hasDbXref "FMA:9536" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "right ventricular endocardium" . [] oboInOwl:hasDbXref "EMAPA:17341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "endocardial lining of right ventricle" . [] oboInOwl:hasDbXref "VHOG:0001235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009712 ; owl:annotatedTarget "right ventricle endocardial tissue" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget _:genid148985 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "Any endocardium that is part of the left ventricle of the heart." . [] oboInOwl:source "FMA:9559" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "Endocardium of ventricle which is continuous with mitral valve, aortic valve, atrioventricular septum and the tunica intima of the aorta." . [] oboInOwl:hasDbXref "VHOG:0001233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "left ventricle endocardium" . [] oboInOwl:hasDbXref "FMA:9559" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "left ventricular endocardium" . [] oboInOwl:hasDbXref "EMAPA:17338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "endocardial lining of left ventricle" . [] oboInOwl:hasDbXref "VHOG:0001233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009713 ; owl:annotatedTarget "left ventricle endocardial tissue" . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget obo:UBERON_0009292 . [] oboInOwl:notes "inconsistent" ; oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget _:genid148994 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget _:genid148996 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?s=intermaxillary+segment" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget "The primordial mass of tissue formed by the merging of the medial nasal prominences of the embryo; it contributes to the intermaxillary portion of the upper jaw, the prolabial portion of the upper lip, and the primary palate." . [] oboInOwl:hasDbXref "Wikipedia:Intermaxillary_segment" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget "globular process" . _:genid147172 oboInOwl:hasDbXref "Wikipedia:Intermaxillary_segment" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget "globular processes of his" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001447 . [] oboInOwl:hasDbXref "Wikipedia:Intermaxillary_segment" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009714 ; owl:annotatedTarget "intermaxillary segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009715 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a stomodeum." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009722 ; owl:annotatedTarget _:genid149007 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009722 ; owl:annotatedTarget _:genid149010 . [] oboInOwl:hasDbXref "EHDAA2:0004621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009722 ; owl:annotatedTarget "pharyngeal arch endoderm" . [] oboInOwl:hasDbXref "MP:0011222" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009744 ; owl:annotatedTarget "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009744 ; owl:annotatedTarget "EMAPA:37898" . [] oboInOwl:hasDbXref "MP:0011224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009745 ; owl:annotatedTarget "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009745 ; owl:annotatedTarget "EMAPA:37897" . [] oboInOwl:hasDbXref "MP:0011261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009749 ; owl:annotatedTarget "The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009749 ; owl:annotatedTarget "EMAPA mapping from TH" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009749 ; owl:annotatedTarget "limb mesoderm" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "PMID:8838010" . [] oboInOwl:hasDbXref "MP:0011264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009751 ; owl:annotatedTarget "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." . [] oboInOwl:hasDbXref "EMAPA:36438" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009751 ; owl:annotatedTarget "heart mesenchyme" . [] oboInOwl:hasDbXref "MP:0011265" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009752 ; owl:annotatedTarget "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009758 ; owl:annotatedTarget "A ganglion that is part of a abdominal segment of trunk." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009767 ; owl:annotatedTarget "An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx." . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009767 ; owl:annotatedTarget "PIJ joint" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009767 ; owl:annotatedTarget "PIP joint" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009768 ; owl:annotatedTarget "An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx." . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009768 ; owl:annotatedTarget "DIJ joint" . [] oboInOwl:hasDbXref "Wikipedia:Interphalangeal_articulations_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009768 ; owl:annotatedTarget "DIP joint" . [] oboInOwl:hasDbXref "DOI:10.1371/journal.pone.0099864", "GO:0061333", "GOC:dph", "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009773 ; owl:annotatedTarget "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009773 ; owl:annotatedTarget "renal tubule (generic)" . [] oboInOwl:hasDbXref "OBOL:automatic", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009773 ; owl:annotatedTarget "tubule of excretory system" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009778 ; owl:annotatedTarget _:genid149069 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002014 ; owl:annotatedTarget obo:CL_0000549 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009778 ; owl:annotatedTarget _:genid149071 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009778 ; owl:annotatedTarget "A serous sac that has the pleura and the pleural cavity as parts." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009778 ; owl:annotatedTarget "despite its name the class EHDAA2:0004737 is not a true cavity, it corresponds to what we call the sac" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002014 ; owl:annotatedTarget "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." . [] oboInOwl:hasDbXref "Wikipedia:Acinus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009842 ; owl:annotatedTarget "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." . [] oboInOwl:hasDbXref "FMA:55588" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0009842 ; owl:annotatedTarget "acinus" . [] oboInOwl:hasDbXref "Wikipedia:Acinus" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009842 ; owl:annotatedTarget "acini" . (obo:UBERON_0005154 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002367 ] ) . [] oboInOwl:hasDbXref "GO:0060527", "OBOL:automatic", "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009843 ; owl:annotatedTarget "A solid cord of prostate epithelium." . [] oboInOwl:hasDbXref "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009843 ; owl:annotatedTarget "cord of prostate epithelium" . _:genid147266 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009844 ; owl:annotatedTarget _:genid149097 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004470 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009844 ; owl:annotatedTarget "An anatomical space that surrounded_by a primitive urogenital sinus." . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002221 ; owl:someValuesFrom obo:UBERON_0000164 ] ) . ( ) . [] oboInOwl:source "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009845 ; owl:annotatedTarget _:genid149101 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009845 ; owl:annotatedTarget "Mesenchyme that surrounds primitive urogenital sinus." . [] oboInOwl:hasDbXref "PMID:18977204" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009845 ; owl:annotatedTarget "UGM" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009846 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009846 ; owl:annotatedTarget _:genid149113 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009846 ; owl:annotatedTarget _:genid149115 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009846 ; owl:annotatedTarget "An epithelium that is part of a embryonic cloaca." . [] oboInOwl:hasDbXref "EHDAA2:0004585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0009846 ; owl:annotatedTarget "cloacal epithelium" . ( ) . _:genid147288 oboInOwl:source "PMID:18977204" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009847 ; owl:annotatedTarget _:genid149124 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002375 . [] oboInOwl:source "PMID:18977204" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009847 ; owl:annotatedTarget _:genid149126 . _:genid147290 oboInOwl:hasDbXref "GO:0060515", "GOC:dph", "PMID:18977204" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009847 ; owl:annotatedTarget "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001740 . (obo:UBERON_0009856 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001555 ] ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009854 ; owl:annotatedTarget "Branch or outpocketing of the digestive tract." . [] oboInOwl:hasDbXref "FBbt:00100316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009854 ; owl:annotatedTarget "diverticulum of gut" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Reaxys:2060565" . _:genid147301 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000464 _:genid147303 ) ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0003716 . _:genid147303 a owl:Restriction ; owl:onProperty obo:RO_0002372, obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0002375, obo:UBERON_0004714 . _:genid147305 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001740, obo:UBERON_0004714 . _:genid147307 oboInOwl:hasDbXref "BTO:0003447", "Wikipedia:Cave_of_septum_pellucidum" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "A space enclosed within the laminae of the septum pelludicum, the membranous partition that seperates the frontal horns of the ventricle. contains cerebrospinal fluid (CSF) that filters from the ventricles through the septal laminae. bounded anteriorly by the genu of the corpus callosum; superiorly by the body of the corpus callosum; posteriorly by the anterior limb and pillars of the fornix; inferiorly by the anterior commissure and the rostrum of the corpus callosum; and laterally by the leaflets of the septum pellucidum." ; owl:onProperty obo:RO_0002568 ; owl:someValuesFrom obo:UBERON_0008572 . [] oboInOwl:source "ncithesaurus:Fifth_Ventricle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "UMLS:C0228158" . [] oboInOwl:hasDbXref "FMA:61874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "cave of septum pellucidum" . [] oboInOwl:hasDbXref "FMA:61874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "cavum of septum pellucidum" . [] oboInOwl:hasDbXref "FMA:61874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "septum pellucidum cave" . [] oboInOwl:hasDbXref "FMA:61874" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "ventriculus septi pellucidi" . [] oboInOwl:hasDbXref "Wikipedia:Cave_of_septum_pellucidum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "cavum septi pellucidi" . [] oboInOwl:hasDbXref "FMA:61874", "Wikipedia:Cave_of_septum_pellucidum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009857 ; owl:annotatedTarget "fifth ventricle" . [] oboInOwl:hasDbXref "Wikipedia:Endosteum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009859 ; owl:annotatedTarget "A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones." . _:genid147319 oboInOwl:source "ncithesaurus:Endosteum" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009859 ; owl:annotatedTarget "UMLS:C0222658" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001733 . (obo:UBERON_0034944 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) . ( ) . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Stomach#Sections" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009870 ; owl:annotatedTarget "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." . [] oboInOwl:hasDbXref "FMA:14558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009870 ; owl:annotatedTarget "gastric zone" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009871 ; owl:annotatedTarget "Outer portion of the renal cortex. Site of formation of medullary and cortical elements." . [] oboInOwl:hasDbXref "PMID:29449449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009871 ; owl:annotatedTarget "cortical nephrogenic niche" . [] oboInOwl:hasDbXref "PMID:29449449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009871 ; owl:annotatedTarget "cortical nephrogenic zone" . _:genid147333 a owl:Restriction ; owl:onProperty obo:RO_0002005, obo:RO_0002551 ; owl:someValuesFrom obo:UBERON_0001647, obo:UBERON_0010546 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009877 ; owl:annotatedTarget _:genid149173 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009877 ; owl:annotatedTarget _:genid149175 . [] oboInOwl:hasDbXref "MA:th", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009877 ; owl:annotatedTarget "Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region." . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009877 ; owl:annotatedTarget "cannon region" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009877 ; owl:annotatedTarget "equine cannon region" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005022" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "Limb skeleton subdivision consisting of endochondral bones increasing the freedom of movement of the autopodia, and located between zeugopodia and autopodia.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005022" ; oboInOwl:ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" . [] oboInOwl:hasDbXref "VSAO:0005022", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "basipodium skeleton" . _:genid147353 oboInOwl:hasDbXref "VSAO:0005022" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "mesopodial skeleton" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "mesopodium skeleton" . _:genid147355 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "skeletal parts of mesopodium" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001683 . [] oboInOwl:hasDbXref "VSAO:0005022", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "basipodium" . [] oboInOwl:hasDbXref "VSAO:0005022", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009878 ; owl:annotatedTarget "mesopodium" . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "VSAO:0005024", "https://github.com/obophenotype/uberon/issues/94" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "Subdivision of skeleton that consists of endochondral elements distal to the zeugopodial skeletal elements which constitute the proximal region of the posterior autopod skeleton[PHENOSCAPE:ad]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000220" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "Segment of the leg corresponding to the tarsus. It consists of several elements that articulate with the tibia and fibula at one end and the metatarsals at the other end.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001160" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" . [] oboInOwl:source "PHENOSCAPE:ad" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002015 ; owl:annotatedTarget obo:CL_0000550 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "we assume MA:tarsus belongs here, as there is a distinct class MA:ankle, with the tarsal bone being part of the former. XAO:tarsus is part of the hindlimb skeleton. FMA set-of class lacks definition but we assume this to be equivalent." . [] oboInOwl:hasDbXref "FMA:71339" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "set of tarsal bones" . [] oboInOwl:hasDbXref "FMA:71339" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "tarsal bones set" . [] oboInOwl:hasDbXref "XAO:0003211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "tarsalia" . [] oboInOwl:hasDbXref "VSAO:0005024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "basipodium" . [] oboInOwl:hasDbXref "VSAO:0005024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "mesopodium" . [] oboInOwl:hasDbXref "XAO:0003211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009879 ; owl:annotatedTarget "tarsus" . _:genid147379 a owl:Restriction ; owl:onProperty obo:RO_0002005, obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001647, obo:UBERON_0004452 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002015 ; owl:annotatedTarget "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/93" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "Subdivision of skeleton that consists of the endochondral elements distal to the anterior limb/fin zeugopodial skeletal elements which constitute the proximal region of the anterior autopod skeleton[PHENOSCAPE:ad]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000201" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "Segment of the forearm corresponding to the carpus. It consists of several elements that articulate with the radius and ulna at one end and the metacarpals at the other end.[AAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001161" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" . _:genid147388 oboInOwl:source "Wikipedia:Carpus#Evolutionary_variations" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present[PHENOSCAPE:ad]." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "we assume MA:carpus belongs here, as there is a distinct class MA:wrist, with the carpal bone being part of the former. XAO:carpus is part of the forelimb skeleton. FMA set-of class lacks definition but we assume this to be equivalent." . _:genid147390 oboInOwl:hasDbXref "EMAPA:25056", "FMA:71335" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "carpal bones" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002397 . [] oboInOwl:hasDbXref "FMA:71335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "carpal bones set" . [] oboInOwl:hasDbXref "MA:0000040", "XAO:0003207" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "carpus" . [] oboInOwl:hasDbXref "AAO:0000201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "fore mesopodium" . [] oboInOwl:hasDbXref "Wikipedia:Carpus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "ossa carpi" . [] oboInOwl:hasDbXref "FMA:71335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009880 ; owl:annotatedTarget "set of carpal bones" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009881 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009881 ; owl:annotatedTarget _:genid149237 . [] oboInOwl:hasDbXref "ZFA:0005041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009881 ; owl:annotatedTarget "ALPM" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "CHOLESTEROL" . [] oboInOwl:hasDbXref "Wikipedia:Anal_columns" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009882 ; owl:annotatedTarget "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP]." . [] oboInOwl:source "ncithesaurus:Anal_Column" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009882 ; owl:annotatedTarget "UMLS:C0227428" . [] oboInOwl:hasDbXref "FMA:15713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009882 ; owl:annotatedTarget "column of Morgagni" . [] oboInOwl:hasDbXref "Wikipedia:Anal_columns" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009882 ; owl:annotatedTarget "columnae anales" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget obo:UBERON_0000064 . _:genid147408 oboInOwl:source "MP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget _:genid149247 ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0008199 . [] oboInOwl:hasDbXref "MP:0011347", "Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla." . _:genid147410 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "FMA says parenchyma, MP says cortex" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "EMAPA:37906" . _:genid147412 oboInOwl:hasDbXref "MP:0011347" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "Ferrein's pyramid" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001684 . [] oboInOwl:hasDbXref "MP:0011347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "kidney medullary ray" . _:genid147414 oboInOwl:hasDbXref "MP:0011347" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009883 ; owl:annotatedTarget "renal medullary ray" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0008199 . [] oboInOwl:hasDbXref "Wikipedia:Interlobar_arteries", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "An artery that supplies a renal lobe." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "FMA only has the set term" . _:genid147421 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "EMAPA:37091" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "arteriae interlobares renis" . _:genid147423 oboInOwl:hasDbXref "FMA:71637" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "interlobar artery of kidney" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001684 . [] oboInOwl:hasDbXref "MP:0011355" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "renal interlobar artery" . _:genid147425 oboInOwl:hasDbXref "Wikipedia:Interlobar_arteries" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "arteriae interlobares renis" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011386 . [] oboInOwl:hasDbXref "FMA:71637" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "interlobar arteries of kidney" . [] oboInOwl:hasDbXref "FMA:71637" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009885 ; owl:annotatedTarget "set of interlobar arteries of kidney" . [] oboInOwl:hasDbXref "Wikipedia:Interlobar_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "The interlobar veins are veins of the renal circulation which drain the renal lobes." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "FMA only has the set term" . [] oboInOwl:hasDbXref "FMA:71631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "interlobar vein of kidney" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "venae interlobares renis" . [] oboInOwl:hasDbXref "FMA:71631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "interlobar veins of kidney" . [] oboInOwl:hasDbXref "FMA:71631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "set of interlobar veins of kidney" . [] oboInOwl:hasDbXref "Wikipedia:Interlobar_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009887 ; owl:annotatedTarget "venae interlobares renis" . [] oboInOwl:source "GO:0003129" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget _:genid149282 . [] oboInOwl:source "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget _:genid149284 . [] oboInOwl:source "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget _:genid149286 . [] oboInOwl:hasDbXref "GO:0003139", "GOC:mtg_heart", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." . _:genid147444 oboInOwl:source "PMID:17276708" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "extra-cardiac population of mesodermal progenitors that gives rise to the right ventricle and outflow tract[PMID:17276708]." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:source "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "In general, the two studies in chick concluded that the contribution of the SHF was to the outflow tract, whereas the mouse work suggested that the second lineage contributed more broadly to the heart, including the outflow tract and much or all of the right ventricle [11-14]. These different conclusions may represent differences in the experimental approaches used or may represent bona fide differences in the contribution of the second lineage to the hearts of birds compared to mammals [11]. Alternatively, the secondary/anterior heart fields described in the chick may represent a subset of a broader field that makes a more substantial contribution to the heart, as the mouse studies suggested" . [] oboInOwl:hasDbXref "PMID:17276708" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "anterior heart field" . [] oboInOwl:hasDbXref "Geisha:syn", "NCBITaxon:8782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "anterior/second heart field" . [] oboInOwl:hasDbXref "XAO:0004186" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "second heart field" . [] oboInOwl:hasDbXref "XAO:0004186" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009889 ; owl:annotatedTarget "SHF" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009891 ; owl:annotatedTarget "Mesenchyme that is part of a developing face." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009911 ; owl:annotatedTarget obo:UBERON_0000063 . [] oboInOwl:source "ncithesaurus:Lobule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009911 ; owl:annotatedTarget "UMLS:C0921005" . [] oboInOwl:hasDbXref "FMA:45737", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009911 ; owl:annotatedTarget "lobulus" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009912 ; owl:annotatedTarget obo:UBERON_0000063 . [] oboInOwl:hasDbXref "ncithesaurus:Lobe" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009912 ; owl:annotatedTarget "A portion of an organ, such as the liver, lung, breast, or brain." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002016 ; owl:annotatedTarget obo:CL_0000550 . [] oboInOwl:hasDbXref "FMA:45728", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009912 ; owl:annotatedTarget "lobus" . [] oboInOwl:hasDbXref "MP:0011381", "Wikipedia:Renal_lobe" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]." . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys" . [] oboInOwl:source "ncithesaurus:Kidney_Lower_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "UMLS:C0736382" . [] oboInOwl:hasDbXref "MP:0011381" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "kidney lobe" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002016 ; owl:annotatedTarget "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." . [] oboInOwl:hasDbXref "Wikipedia:Renal_lobe" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "lobi renalis" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "lobus renalis" . [] oboInOwl:hasDbXref "Wikipedia:Renal_lobe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009913 ; owl:annotatedTarget "lobi renales" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget _:genid149322 . [] oboInOwl:hasDbXref "MP:0011382", "Wikipedia:Cortical_lobule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys." . [] oboInOwl:hasDbXref "MP:0011382" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "kidney lobule" . [] oboInOwl:hasDbXref "MP:0011382", "Wikipedia:Cortical_lobule" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "cortical lobule" . _:genid147484 oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "cortical lobule of kidney" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001774 . [] oboInOwl:hasDbXref "Wikipedia:Cortical_lobule" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "lobuli corticales renis" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "lobulus corticalis renalis" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "renal cortical lobule" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "renculus" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "reniculus" . [] oboInOwl:hasDbXref "http://www.mondofacto.com/facts/dictionary?lobus+renalis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009914 ; owl:annotatedTarget "renunculus" . _:genid147497 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009916 ; owl:annotatedTarget "An anatomical wall that is part of a ureter." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001774 . [] oboInOwl:hasDbXref "FMA:15888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009916 ; owl:annotatedTarget "ureteral wall" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Cholesterol" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009917 ; owl:annotatedTarget _:genid149351 . [] oboInOwl:hasDbXref "MP:0011376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009917 ; owl:annotatedTarget "The region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009917 ; owl:annotatedTarget "EMAPA:37886" . ( ) . [] oboInOwl:hasDbXref "MP:0011426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009919 ; owl:annotatedTarget "The smooth muscle tissue surrounding the epithelium of the ureter." . [] oboInOwl:hasDbXref "MP:0011426" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009919 ; owl:annotatedTarget "ureteral smooth muscle" . [] oboInOwl:hasDbXref "EMAPA:28844" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009919 ; owl:annotatedTarget "ureteral smooth muscle layer" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009920 ; owl:annotatedTarget obo:UBERON_0007530 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009920 ; owl:annotatedTarget _:genid149366 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009953 ; owl:annotatedTarget "A multicellular organism that existence_starts_with a post-embryonic stage." . [] oboInOwl:hasDbXref "MA:0002405" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009953 ; owl:annotatedTarget "TS28 mouse" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009953 ; owl:annotatedTarget "post-hatching organism" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009953 ; owl:annotatedTarget "post-natal organism" . [] oboInOwl:hasDbXref "MA:0002405" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0009953 ; owl:annotatedTarget "postnatal mouse" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009955 ; owl:annotatedTarget obo:UBERON_0002546 . [] oboInOwl:hasDbXref "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009955 ; owl:annotatedTarget "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." . [] oboInOwl:source "NCBIBook:NBK53171" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0009955 ; owl:annotatedTarget "While some sensory placodes (otic and olfactory) may have homologues in basal chordates (Wada et al., 1998), the so-called neurogenenic placodes (trigeminal, otic, lateral line and epibranchial placodes) appear to have emerged at a later time (Shimeld and Holland, 2000)" . [] oboInOwl:hasDbXref "ZFA:0001309" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009955 ; owl:annotatedTarget "neurogenic placodes" . [] oboInOwl:hasDbXref "Wikipedia:Neurogenic_placodes" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009955 ; owl:annotatedTarget "placodae neurogenicae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget _:genid149391 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget _:genid149396 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget _:genid149398 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget "An anatomical space that is enclosed by a urinary bladder." . [] oboInOwl:hasDbXref "FMA:15924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget "bladder cavity" . [] oboInOwl:hasDbXref "FMA:15924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget "cavity of urinary bladder" . [] oboInOwl:hasDbXref "FMA:15924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget "lumen of urinary bladder" . _:genid147553 oboInOwl:hasDbXref "FMA:15924" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009958 ; owl:annotatedTarget "urinary bladder lumen" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004766 . [] oboInOwl:source "FMA-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009970 ; owl:annotatedTarget _:genid149409 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009970 ; owl:annotatedTarget "An epithelium that is part of a pancreatic duct." . [] oboInOwl:hasDbXref "FMA:67681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009970 ; owl:annotatedTarget "pancreatic duct epithelium" . [] oboInOwl:hasDbXref "FMA:67681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009970 ; owl:annotatedTarget "pancreatic ductal epithelium" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009972 ; owl:annotatedTarget _:genid149420 . [] oboInOwl:hasDbXref "MP:0011487" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009972 ; owl:annotatedTarget "The junction between the ureter and the renal pelvis of the kidney." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009972 ; owl:annotatedTarget "EMAPA:37782" . [] oboInOwl:hasDbXref "FMA:15898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009972 ; owl:annotatedTarget "pelviureteric junction" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009973 ; owl:annotatedTarget _:genid149432 . [] oboInOwl:hasDbXref "MP:0011488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009973 ; owl:annotatedTarget "The valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009973 ; owl:annotatedTarget "EMAPA:37783" . [] oboInOwl:hasDbXref "MA:0003020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009973 ; owl:annotatedTarget "vesico-ureteral junction" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "http://www.merriam-webster.com/dictionary/condyle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget "An articular prominence of a bone, typically present in pairs, resembling a pair of knuckles. Examples: Condyle of humerus, condyle of femur." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002259" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget "Protuberance on a bone that participates in a joint with another bone.[TAO]" . [] oboInOwl:source "Wikipedia:Condyle_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget "the round prominence at the end of a bone, most often part of a joint - an articulation with another bone[WP][Wikipedia:Condyle_(anatomy)]." . [] oboInOwl:source "ncithesaurus:Condyle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget "UMLS:C0524414" . [] oboInOwl:hasDbXref "Wikipedia:Condyle_(anatomy)" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009979 ; owl:annotatedTarget "condylus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009980 ; owl:annotatedTarget "A condyle that is part of a distal epiphysis of femur." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000900" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009980 ; owl:annotatedTarget "Convex articular facet of the distal head of the femur that articulates with the proximal head of the fibula.[AAO]" . [] oboInOwl:hasDbXref "AAO:0000900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009980 ; owl:annotatedTarget "fibular condyle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget _:genid149451 . [] oboInOwl:hasDbXref "Wikipedia:Medial_condyle_of_femur" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget "The medial condyle is one of the two projections on the lower extremity of femur. The medial condyle is larger than the lateral (outer) condyle due to more weight bearing caused by the center of gravity being medial to the knee. On the posterior surface of the condyle the linea aspera (a ridge running down the posterior shaft of the femur) turns into the medial supracondylar ridge. The outermost protrusion on the medial surface of the medial condyle is referred to as the 'medial epicondyle' and can be palpated by running fingers medially from the patella with the knee in flexion." . [] oboInOwl:hasDbXref "FMA:32858", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget "condylus medialis femoris" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "cholest-5-en-3beta-ol" . [] oboInOwl:hasDbXref "Wikipedia:Medial_condyle_of_femur" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget "c. medialis femoris" . [] oboInOwl:hasDbXref "Wikipedia:Medial_condyle_of_femur" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget "medial condyle of the femur" . [] oboInOwl:hasDbXref "FMA:32858" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0009984 ; owl:annotatedTarget "medial femoral condyle" . _:genid147607 oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=19715" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009988 ; owl:annotatedTarget "The distal end of the humerus, including the trochlea, capitulum and the olecranon, coronoid and radial fossae." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0007124 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009988 ; owl:annotatedTarget "condylus humeri" . [] oboInOwl:hasDbXref "FMA:23377" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009988 ; owl:annotatedTarget "humeral condyle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002017 ; owl:annotatedTarget obo:CL_0000552 . [] oboInOwl:hasDbXref "Wikipedia:Tibial_condyle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0009989 ; owl:annotatedTarget "One of the lateral or medial condyles of the tibia." . _:genid147615 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000899" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0009989 ; owl:annotatedTarget "Convex articular facet of the distal head of the femur that articulates with the proximal head of the tibia.[AAO]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033 . [] oboInOwl:hasDbXref "AAO:0000899" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0009989 ; owl:annotatedTarget "tibial condyle" . _:genid147617 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000061 [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0001993 ] ) ; owl:onProperty obo:RO_0002495 ; owl:someValuesFrom obo:UBERON_0006238 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002017 ; owl:annotatedTarget "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." . [] oboInOwl:hasDbXref "CARO:0010000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010000 ; owl:annotatedTarget "An anatomical structure that has more than one cell as a part." . [] oboInOwl:hasDbXref "FBbt:00100313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010000 ; owl:annotatedTarget "multicellular structure" . _:genid147625 oboInOwl:source "MP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010005 ; owl:annotatedTarget _:genid149479 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 . [] oboInOwl:hasDbXref "MP:0011522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010005 ; owl:annotatedTarget "The vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010005 ; owl:annotatedTarget "placental labyrinth villi" . [] oboInOwl:hasDbXref "NLXANAT:20090509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010009 ; owl:annotatedTarget "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." . [] oboInOwl:hasDbXref "FMA:256381" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010009 ; owl:annotatedTarget "set of nuclei of neuraxis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget obo:UBERON_0010009 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget _:genid149493 . [] oboInOwl:source "MA", "NIF" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget _:genid149496 . _:genid147640 oboInOwl:hasDbXref "BIRNLEX:826" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001757 . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001696" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" . _:genid147642 oboInOwl:source "ncithesaurus:Basal_Ganglia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "UMLS:C0004781" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0003725 . [] oboInOwl:hasDbXref "FMA:84013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "basal ganglia" . [] oboInOwl:hasDbXref "FMA:84013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "basal ganglia set" . [] oboInOwl:hasDbXref "PBA:BN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "basal nuclei (basal ganglia)" . [] oboInOwl:hasDbXref "FMA:84013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "set of basal ganglia" . [] oboInOwl:hasDbXref "NeuroNames:2677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "cerebral nuclei" . [] oboInOwl:hasDbXref "FMA:84013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "set of basal nuclei" . [] oboInOwl:hasDbXref "NeuroNames:2677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010011 ; owl:annotatedTarget "subcortical nuclei" . _:genid147650 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget obo:UBERON_0007499 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004161 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget _:genid149509 . _:genid147652 oboInOwl:source "EHDAA2", "ISBN:0073040584", "PMID:11237469" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget _:genid149511 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 . [] oboInOwl:hasDbXref "ISBN:0124020607", "VHOG:0001297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget "The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity." . _:genid147654 oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001297" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417", "http://bgee.unil.ch/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[well established][VHOG]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003894 . [] oboInOwl:source "ncithesaurus:Tubotympanic_Recess" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget "UMLS:C1284046" . [] oboInOwl:hasDbXref "VHOG:0001297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010020 ; owl:annotatedTarget "tubotympanic recess" . _:genid147661 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010031 ; owl:annotatedTarget "Mesenchyme that is part of a pharyngeal arch 6." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006235 . _:genid147663 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001723, obo:UBERON_0008835 . [] oboInOwl:source "ISBN:1607950324" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget _:genid149522 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget obo:UBERON_0010033 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "check NCIT" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "EMAPA:37437" . _:genid147672 oboInOwl:source "ncithesaurus:Apex_of_the_Tongue" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "UMLS:C0226946" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004876 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "anterior 2/3 of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "anterior 2/3 of tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "anterior two thirds of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "apex linguae" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "apex of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "buccal part of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "front of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "oral part of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_tongue" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010032 ; owl:annotatedTarget "pars anterior dorsi linguae" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget _:genid149543 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget _:genid149545 . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "The Posterior tongue, or pharyngeal part, is the part of the tongue behind the terminal sulcus. At its root, it is directed backward, and connected with the hyoid bone by the Hyoglossi and Genioglossi muscles and the hyoglossal membrane; with the epiglottis by three folds (glossoepiglottic) of mucous membrane; with the soft palate by the glossopalatine arches; and with the pharynx by the Constrictores pharyngis superiores and the mucous membrane. It is derived primarily from the third pharyngeal arch. (The second arch has a substantial contribution during fetal development, but this later atrophies. The fourth arch may also contribute, depending upon how the boundaries of the tongue are defined.)." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "EMAPA:37438" . [] oboInOwl:source "ncithesaurus:Base_of_the_Tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "UMLS:C0226958" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "base of tongue" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pars posterior (dorsum linguae)" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pars posterior dorsi linguae" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pars posterior linguae" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pars postsulcalis (dorsum linguae)" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pharyngeal part of tongue" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pharyngeal portion of dorsum of tongue" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "posterior part of dorsum of tongue" . [] oboInOwl:hasDbXref "FMA:54645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "postsulcal part of dorsum of tongue" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "base of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "pharyngeal part of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "posterior 1/3 of the tongue" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "posterior third of tongue" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "cholesterol" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002018 ; owl:annotatedTarget obo:CL_0000552 . [] oboInOwl:hasDbXref "Wikipedia:Posterior_tongue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010033 ; owl:annotatedTarget "radix linguae" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010039 ; owl:annotatedTarget "An organ of the digestive tract that is capable of retaining and storing food." . _:genid147704 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003104 _:genid147706 ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000057 . _:genid147706 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000327, obo:UBERON_0004362 . _:genid147708 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010042 ; owl:annotatedTarget "Mesenchyme that is part of a pharyngeal arch 1." ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0004765 . [] oboInOwl:hasDbXref "EMAPA:16128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010042 ; owl:annotatedTarget "mesenchyme of 1st arch" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002018 ; owl:annotatedTarget "An erythroblast that is GlyA-positive and CD71-negative." . _:genid147710 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007238 ] ) ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0007846 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010045 ; owl:annotatedTarget "Mesenchyme that is part of a 1st arch maxillary component." . [] oboInOwl:hasDbXref "EMAPA:16391" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010045 ; owl:annotatedTarget "mesenchyme of maxillary component" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget _:genid149580 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget _:genid149582 . [] oboInOwl:hasDbXref "XAO:0004524", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." . [] oboInOwl:hasDbXref "EMAPA:16550" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget "associated mesenchyme of pharyngeal region" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget "entire branchial arch associated mesenchyme" . [] oboInOwl:hasDbXref "EHDAA2:0001459" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010046 ; owl:annotatedTarget "pharyngeal arch associated mesenchyme" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010047 ; owl:annotatedTarget "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010047 ; owl:annotatedTarget "Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa" . _:genid147731 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001167, obo:UBERON_0009471 . _:genid147733 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010052 ; owl:annotatedTarget "A mucosa that is part of a dorsum of tongue." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004222 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010054 ; owl:annotatedTarget "A malleus endochondral element that is composed primarily of cartilage tissue." . _:genid147745 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001166, obo:UBERON_0006294 . [] oboInOwl:source "http://people.eku.edu/ritchisong/342notes4.htm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010055 ; owl:annotatedTarget obo:UBERON_0011607 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010055 ; owl:annotatedTarget "A stapes endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010056 ; owl:annotatedTarget obo:UBERON_0003103 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010056 ; owl:annotatedTarget "A compound organ that has the potential to develop into a tongue." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010059 ; owl:annotatedTarget obo:UBERON_0002036 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010059 ; owl:annotatedTarget _:genid149621 . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_opening_of_auditory_tube" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "On the lateral wall of the nasal part of the pharynx is the pharyngeal opening of auditory tube (pharyngeal ostium), somewhat triangular in shape, and bounded behind by a firm prominence, the torus or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane." . _:genid147760 oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "ostium pharyngeum tubae auditivae" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000319 . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "ostium pharyngeum tubae auditoriae" . _:genid147762 oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal opening of auditory tube" ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002299 . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal opening of eustachian tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal orifice of auditory tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal orifice of eustachian tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal orifice of pharyngotympanic tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal ostium of auditory tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal ostium of eustachian tube" . [] oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal ostium of pharyngotympanic tube" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002019 ; owl:annotatedTarget obo:CL_0002422 . _:genid147770 oboInOwl:hasDbXref "FMA:54979" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal tubal ostium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002483 . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_opening_of_auditory_tube" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "ostium pharyngeum tubae auditivae" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngeal_opening_of_auditory_tube" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010060 ; owl:annotatedTarget "pharyngeal ostium" . [] oboInOwl:hasDbXref "FMA:55094" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010061 ; owl:annotatedTarget "nasopharynx lumen" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010062 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010062 ; owl:annotatedTarget _:genid149643 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010062 ; owl:annotatedTarget _:genid149645 . [] oboInOwl:hasDbXref "EHDAA2:0004117" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010062 ; owl:annotatedTarget "auditory tube epithelium" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:18539294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002019 ; owl:annotatedTarget "A reticulocyte that is Ly76-high and is Kit-negative." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010062 ; owl:annotatedTarget "eustachian tube epithelium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010063 ; owl:annotatedTarget obo:UBERON_0007499 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010063 ; owl:annotatedTarget _:genid149650 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010063 ; owl:annotatedTarget _:genid149653 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010064 ; owl:annotatedTarget _:genid149659 . [] oboInOwl:hasDbXref "AEO:0000221" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010064 ; owl:annotatedTarget "An anatomical space with at least one opening to another space or the exterior." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010065 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010065 ; owl:annotatedTarget _:genid149663 . [] oboInOwl:source "EHDAA2", "PMID:16313389" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010065 ; owl:annotatedTarget _:genid149665 . _:genid147796 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001352, obo:UBERON_0002190 . [] oboInOwl:hasDbXref "PMID:11237469", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010069 ; owl:annotatedTarget "A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane." . [] oboInOwl:hasDbXref "FMA:56819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010069 ; owl:annotatedTarget "cuticular layer of tympanic membrane" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "(3beta,14beta,17alpha)-cholest-5-en-3-ol" . [] oboInOwl:hasDbXref "FMA:56819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010069 ; owl:annotatedTarget "cuticular stratum of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010069 ; owl:annotatedTarget "outer cuticular layer of tympanic membrane" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010069 ; owl:annotatedTarget "tympanic membrane external acoustic meatus epithelial component" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget obo:UBERON_0010071 . [] oboInOwl:hasDbXref "PMID:11237469", "https://sourceforge.net/tracker/?func=detail&aid=3468783&group_id=76834&atid=1205376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "The intermediate fibrous layer of the tympanic membrane." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "check MA" . [] oboInOwl:hasDbXref "FMA:56830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "connective tissue layer of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "fibrous layer of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "fibrous stratum of tympanic membrane" . [] oboInOwl:hasDbXref "FMA:56830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "intermediate fibrous layer of tympanic membrane" . [] oboInOwl:hasDbXref "MA:0001223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010070 ; owl:annotatedTarget "tympanic endothelium" . [] oboInOwl:hasDbXref "FMA:56732" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010071 ; owl:annotatedTarget "tympanic membrane layer" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010074 ; owl:annotatedTarget _:genid149686 . [] oboInOwl:source "CL", "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010074 ; owl:annotatedTarget _:genid149688 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010074 ; owl:annotatedTarget "Organ system subdivision that consists primarily of chromaffin cells and their supporting structures." . [] oboInOwl:hasDbXref "MESH:A06.224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010074 ; owl:annotatedTarget "argentaffin system" . [] oboInOwl:hasDbXref "XB:curator", "http://www.ncbi.nlm.nih.gov/books/NBK10065/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010075 ; owl:annotatedTarget "One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia." . [] oboInOwl:hasDbXref "FMA:259332" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010076 ; owl:annotatedTarget "Tissue cavity consisting of intercommunicating trabecular spaces in the cancellous bone." . [] oboInOwl:hasDbXref "FMA:259332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010076 ; owl:annotatedTarget "trabecular network of bone tissue" . [] oboInOwl:hasDbXref "FMA:259332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010076 ; owl:annotatedTarget "trabecular space network" . [] oboInOwl:hasDbXref "Wikipedia:Cuboidal_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010077 ; owl:annotatedTarget "An epithelium consisting of cuboidal epithelial cells." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010077 ; owl:annotatedTarget "in NCIT this is glandular" . [] oboInOwl:source "ncithesaurus:Cuboidal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010077 ; owl:annotatedTarget "UMLS:C0682577" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010081 ; owl:annotatedTarget "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002020 ; owl:annotatedTarget obo:CL_0002422 . _:genid147841 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010083 ; owl:annotatedTarget _:genid149716 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004535 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010083 ; owl:annotatedTarget _:genid149718 . [] oboInOwl:source "XAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010083 ; owl:annotatedTarget _:genid149720 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010083 ; owl:annotatedTarget "Mesenchyme that has the potential to develop into a dermis." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010084 ; owl:annotatedTarget _:genid149727 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:1638021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002020 ; owl:annotatedTarget "A reticulocyte that is GlyA-positive." . [] oboInOwl:source "PMID:23586979" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010084 ; owl:annotatedTarget _:genid149729 . [] oboInOwl:source "PMID:23586979" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010084 ; owl:annotatedTarget _:genid149731 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010084 ; owl:annotatedTarget "A structure that will develop into a diaphragm." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010090 ; owl:annotatedTarget "A developing anatomical structure that has the potential to develop into a falx cerebri." . _:genid147860 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002539, obo:UBERON_0003291 . _:genid147862 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0002028, obo:UBERON_0003099 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010091 ; owl:annotatedTarget "A multi-tissue structure that has the potential to develop into a meninx of hindbrain." . [] oboInOwl:hasDbXref "EHDAA2:0000610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010091 ; owl:annotatedTarget "future hindbrain meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010092 ; owl:annotatedTarget "A developing anatomical structure that has the potential to develop into a metencephalon." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010096 ; owl:annotatedTarget "A developing anatomical structure that has the potential to develop into a myelencephalon." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010123 ; owl:annotatedTarget "A gray matter that has the potential to develop into a facial nucleus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010125 ; owl:annotatedTarget "A gray matter that has the potential to develop into a superior salivatory nucleus." . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010129 ; owl:annotatedTarget _:genid149772 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010129 ; owl:annotatedTarget "A femur endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EMAPA:17742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010129 ; owl:annotatedTarget "femoral cartilage condensation" . ( ) . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Cholest-5-en-3beta-ol" . [] oboInOwl:hasDbXref "MP:0004576", "UBERON:cjm", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/1151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010130 ; owl:annotatedTarget "The distal elements of the developing limb of vertebrates that will give rise to the autopod (e.g. manus, pes, paw)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010131 ; owl:annotatedTarget "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." . [] oboInOwl:hasDbXref "FMA:83378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010131 ; owl:annotatedTarget "specialized conducting tissue of heart" . [] oboInOwl:hasDbXref "FMA:83378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010131 ; owl:annotatedTarget "specialized muscle tissue of heart" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002021 ; owl:annotatedTarget obo:CL_0000595 . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0000631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010133 ; owl:annotatedTarget "Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010134 ; owl:annotatedTarget obo:UBERON_0005408 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010134 ; owl:annotatedTarget obo:UBERON_0010133 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010134 ; owl:annotatedTarget "A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid." . _:genid147918 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005408 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001032 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:20134094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002021 ; owl:annotatedTarget "An enucleate erythrocyte that is GlyA-positive." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "EMAPA:37741" . [] oboInOwl:hasDbXref "NeuroNames:2856" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "humerosensory system" . [] oboInOwl:hasDbXref "NeuroNames:2856" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "sensitive circumventricular organs" . [] oboInOwl:hasDbXref "NeuroNames:2856" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "sensitive organs" . [] oboInOwl:hasDbXref "NeuroNames:2856" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "sensory CVOs" . [] oboInOwl:hasDbXref "NeuroNames:2856" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010135 ; owl:annotatedTarget "sensory circumventricular organs" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0010141 ; owl:annotatedTarget _:genid149811 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010141 ; owl:annotatedTarget _:genid149816 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010141 ; owl:annotatedTarget "A sex cord that is part of a indifferent gonad." . [] oboInOwl:hasDbXref "EHDAA2:0004051" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010141 ; owl:annotatedTarget "primitive sex cords" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget obo:UBERON_0006530 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "A bodily secretion that is produced by a seminal vesicle." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "in ncit, seminal fluid is a subtype of seminal vesicle secretion" . [] oboInOwl:source "ncithesaurus:Seminal_Fluid" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "UMLS:C0036614" . [] oboInOwl:source "ncithesaurus:Seminal_Vesicle_Secretion" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "UMLS:C0227987" . [] oboInOwl:hasDbXref "FMA:62969" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "secretion of seminal vesicle" . [] oboInOwl:hasDbXref "FMA:62969" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "seminal vesicle secretion" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010143 ; owl:annotatedTarget "seminal fluid" . _:genid147948 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000079, obo:UBERON_0001630 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010147 ; owl:annotatedTarget obo:UBERON_0005399 . [] oboInOwl:hasDbXref "BTO:0004798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010147 ; owl:annotatedTarget "Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male." . [] oboInOwl:hasDbXref "BTO:0004798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010147 ; owl:annotatedTarget "male accessory gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010152 ; owl:annotatedTarget "A mucous secretion that is produced by glands in the epidermis." . [] oboInOwl:hasDbXref "BTO:0005082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010152 ; owl:annotatedTarget "epidermal mucus" . _:genid147959 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001678, obo:UBERON_0002113 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010155 ; owl:annotatedTarget obo:UBERON_0003685 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010155 ; owl:annotatedTarget "Unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP:Squamosal_suture]." . [] oboInOwl:hasDbXref "FMA:52947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010155 ; owl:annotatedTarget "parietomastoid suture of skull" . [] oboInOwl:hasDbXref "Wikipedia:Sphenofrontal_suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010156 ; owl:annotatedTarget "The Sphenofrontal suture is the cranial suture between the sphenoid bone and the frontal bone." . [] oboInOwl:hasDbXref "FMA:52938" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010156 ; owl:annotatedTarget "frontosphenoid suture" . [] oboInOwl:hasDbXref "FMA:52938" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010156 ; owl:annotatedTarget "sphenofrontal suture of skull" . [] oboInOwl:hasDbXref "Wikipedia:Sphenofrontal_suture" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010156 ; owl:annotatedTarget "sphenofrontal" . [] oboInOwl:hasDbXref "Wikipedia:Sphenofrontal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010156 ; owl:annotatedTarget "sutura sphenofrontalis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002022 ; owl:annotatedTarget obo:CL_0000595 . [] oboInOwl:hasDbXref "Wikipedia:Sphenoparietal_suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010157 ; owl:annotatedTarget "The Sphenoparietal suture is the cranial suture between the sphenoid bone and the parietal bone." . [] oboInOwl:hasDbXref "FMA:52945" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010157 ; owl:annotatedTarget "sphenoparietal suture of skull" . [] oboInOwl:hasDbXref "Wikipedia:Sphenoparietal_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010157 ; owl:annotatedTarget "sutura sphenoparietalis" . _:genid147987 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001683, obo:UBERON_0001987 . [] oboInOwl:hasDbXref "Wikipedia:Sphenozygomatic_suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010158 ; owl:annotatedTarget "The Sphenozygomatic suture is the cranial suture between the sphenoid bone and the zygomatic bone." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:19805084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002022 ; owl:annotatedTarget "An enucleate erythrocyte that is Lyg-76-high." . [] oboInOwl:hasDbXref "FMA:52956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010158 ; owl:annotatedTarget "sphenozygomatica suture of skull" . [] oboInOwl:hasDbXref "Wikipedia:Sphenozygomatic_suture" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010158 ; owl:annotatedTarget "sutura sphenozygomatica" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010160 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a lymphatic vessel." . [] oboInOwl:hasDbXref "FMA:59681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010160 ; owl:annotatedTarget "lumen of lymphatic duct" . [] oboInOwl:hasDbXref "FMA:59681" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010160 ; owl:annotatedTarget "lymphatic vessel lumen" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16113 ; owl:annotatedTarget "Cholesterin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010161 ; owl:annotatedTarget "An anatomical cavity that surrounded_by a blood vessel." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010162 ; owl:annotatedTarget _:genid149894 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010162 ; owl:annotatedTarget "The distal end of the tail." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010162 ; owl:annotatedTarget "EMAPA:37760" . [] oboInOwl:hasDbXref "MA:0002848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010162 ; owl:annotatedTarget "tail tip" . [] oboInOwl:hasDbXref "MA:0002848" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010162 ; owl:annotatedTarget "end of tail" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010163 ; owl:annotatedTarget obo:UBERON_0010165 . [] oboInOwl:hasDbXref "Wikipedia:Eyebrow" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010163 ; owl:annotatedTarget "The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges. Their main function is to protect the eye, but they are also important to human communication and facial expression. It is not uncommon for people to modify their eyebrows by means of hair addition or removal, make up, or piercings." . [] oboInOwl:external_ontology "ncit" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010163 ; owl:annotatedTarget "in NCIT, this is an 'eye appendage'" . [] oboInOwl:source "ncithesaurus:Eyebrow" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010163 ; owl:annotatedTarget "UMLS:C0015420" . [] oboInOwl:hasDbXref "Wikipedia:Eyebrow" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010163 ; owl:annotatedTarget "supercilium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010164 ; owl:annotatedTarget "An anatomical cluster that composed_primarily_of a strand of hair." . [] oboInOwl:hasDbXref "FMA:70752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010164 ; owl:annotatedTarget "hairs" . [] oboInOwl:hasDbXref "FMA:70752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010164 ; owl:annotatedTarget "hairs set" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010164 ; owl:annotatedTarget "pili" . [] oboInOwl:hasDbXref "FMA:70752" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010164 ; owl:annotatedTarget "set of hairs" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010165 ; owl:annotatedTarget "A collection of hairs that is part of a face." . [] oboInOwl:hasDbXref "FMA:70741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010165 ; owl:annotatedTarget "facial hairs set" . [] oboInOwl:hasDbXref "FMA:70741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010165 ; owl:annotatedTarget "set of facial hairs" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010168 ; owl:annotatedTarget "A collection of hair on face that is part of a eyelash." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010168 ; owl:annotatedTarget "cilia" . [] oboInOwl:hasDbXref "FMA:70742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010168 ; owl:annotatedTarget "eyelashes" . [] oboInOwl:hasDbXref "FMA:70742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010168 ; owl:annotatedTarget "eyelashes set" . [] oboInOwl:hasDbXref "FMA:70742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010168 ; owl:annotatedTarget "set of eyelashes" . _:genid148048 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010753 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010171 ; owl:annotatedTarget "A strand of hair that is part of a face." . [] oboInOwl:hasDbXref "FMA:54360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010171 ; owl:annotatedTarget "face hair" . [] oboInOwl:hasDbXref "FMA:54360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010171 ; owl:annotatedTarget "hair of face" . [] oboInOwl:hasDbXref "FMA:54360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010171 ; owl:annotatedTarget "facial hair" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget _:genid149941 . [] oboInOwl:hasDbXref "MP:0011572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "The portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles." . [] oboInOwl:source "http://medical-dictionary.thefreedictionary.com/aortic+bulb" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "The dilated first part of the aorta containing the aortic semilunar valves and the aortic sinuses." . [] oboInOwl:hasDbXref "MP:0011575" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "aorta bulb" . [] oboInOwl:hasDbXref "FMA:3740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "aortic bulb" . [] oboInOwl:hasDbXref "MP:0011572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "aortic root" . [] oboInOwl:hasDbXref "FMA:3740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "bulb of ascending aorta" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "bulbus aortae" . [] oboInOwl:hasDbXref "FMA:3740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "root of aorta" . [] oboInOwl:hasDbXref "FMA:3740" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010172 ; owl:annotatedTarget "supraaortic valve area" . [] oboInOwl:hasDbXref "GO:0060344", "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010183 ; owl:annotatedTarget "A trabecula that is part of a liver." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010183 ; owl:annotatedTarget "liver trabeculae" . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010186 ; owl:annotatedTarget "Any of the numerous small mucous-secreting glands located in the wall of the penile urethra." . [] oboInOwl:source "ncithesaurus:Urethral_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010186 ; owl:annotatedTarget "UMLS:C1314737" . [] oboInOwl:hasDbXref "FMA:21443" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010186 ; owl:annotatedTarget "Littre's gland" . [] oboInOwl:hasDbXref "FMA:21443" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010186 ; owl:annotatedTarget "urethral gland (male)" . [] oboInOwl:hasDbXref "Wikipedia:Urethral_gland" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010186 ; owl:annotatedTarget "glandulae urethrales urethrae masculinae" . _:genid148086 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010187 ; owl:annotatedTarget "An urethral gland that is part of a female urethra." ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002224 . [] oboInOwl:hasDbXref "FMA:21444" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010187 ; owl:annotatedTarget "urethral gland (female)" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010188 ; owl:annotatedTarget obo:UBERON_0034944 . [] oboInOwl:hasDbXref "EHDAA2:0003250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010188 ; owl:annotatedTarget "A roughly circular bulge in a surface." . ( ) . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010189 ; owl:annotatedTarget "part_of in EHDAA2. Only child in MA." . [] oboInOwl:hasDbXref "EHDAA2:0001762" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010189 ; owl:annotatedTarget "right venous valve" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010191 ; owl:annotatedTarget _:genid149982 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010192 ; owl:annotatedTarget _:genid149988 . [] oboInOwl:hasDbXref "ISBN:0073040584", "Wikipedia:Gonadal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010192 ; owl:annotatedTarget "One of the laterally paired arteries that supply the gonads." . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010194 ; owl:annotatedTarget "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010225" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BJB" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010194 ; owl:annotatedTarget "Part of the circulatory system which includes the ventral abdominal vein, pelvic veins, and portal vein and collects blood from the pelvic region, liver, gall bladder and stomach.[AAO]" . [] oboInOwl:hasDbXref "AAO:0010225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010194 ; owl:annotatedTarget "hepatic-portal system" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010199 ; owl:annotatedTarget obo:UBERON_0000466 . [] oboInOwl:hasDbXref "CARO:0001004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010199 ; owl:annotatedTarget "An anatomical boundary that corresponds to some physical discontinuity." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010204 ; owl:annotatedTarget "A vasculature that is part of a post-anal tail." . [] oboInOwl:external_ontology "XAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010204 ; owl:annotatedTarget "isa blood vessel in XAO" . [] oboInOwl:hasDbXref "ZFA:0005037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010204 ; owl:annotatedTarget "post-vent vasculature" . [] oboInOwl:hasDbXref "ZFA:0005037" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010204 ; owl:annotatedTarget "tail vasculature" . _:genid148124 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:CL_0000738, obo:UBERON_0003078 . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010210 ; owl:annotatedTarget _:genid150014 . [] oboInOwl:hasDbXref "BTO:0000102", "Wikipedia:Thrombus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010210 ; owl:annotatedTarget "A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network." . [] oboInOwl:hasDbXref "Wikipedia:Thrombus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010210 ; owl:annotatedTarget "hemostatic plug" . [] oboInOwl:hasDbXref "BTO:0000102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010210 ; owl:annotatedTarget "thrombus" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010212 ; owl:annotatedTarget _:genid150019 . _:genid148133 oboInOwl:hasDbXref "AAO:0000267" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010212 ; owl:annotatedTarget "Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006218 . [] oboInOwl:hasDbXref "EHDAA2:0000904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010212 ; owl:annotatedTarget "laryngeal cartilage system" . _:genid148135 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005092, obo:UBERON_0008895 . [] oboInOwl:source "EHDAA2-abstracted" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010213 ; owl:annotatedTarget _:genid150026 . [] oboInOwl:source "EHDAA2-abstracted" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010213 ; owl:annotatedTarget _:genid150028 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010215 ; owl:annotatedTarget obo:UBERON_0005856 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010215 ; owl:annotatedTarget _:genid150031 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010215 ; owl:annotatedTarget _:genid150033 . _:genid148141 oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=87317" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010215 ; owl:annotatedTarget "Paired primordial elevations, on either side of the embryonic larynx, within which the arytenoid cartilages are formed." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003823 . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010215 ; owl:annotatedTarget "EHDAA2 and EMAPA appear to be inconsistent" . _:genid148143 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010220 ; owl:annotatedTarget _:genid150037 ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001446 . [] oboInOwl:hasDbXref "EMAPA:17387" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010220 ; owl:annotatedTarget "arytenoid swelling pre-cartilage condensation" . _:genid148145 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001448, obo:UBERON_0008895 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010221 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010221 ; owl:annotatedTarget _:genid150041 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010221 ; owl:annotatedTarget _:genid150044 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010221 ; owl:annotatedTarget _:genid150046 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010221 ; owl:annotatedTarget _:genid150048 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010223 ; owl:annotatedTarget "A pupil that is part of a left eye." . [] oboInOwl:hasDbXref "FMA:58254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010223 ; owl:annotatedTarget "pupil of left eye" . _:genid148168 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010224 ; owl:annotatedTarget "A pupil that is part of a right eye." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004581 . [] oboInOwl:hasDbXref "FMA:58253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010224 ; owl:annotatedTarget "pupil of right eye" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002024 ; owl:annotatedTarget obo:CL_0000553 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010225 ; owl:annotatedTarget _:genid150069 . [] oboInOwl:hasDbXref "Wikipedia:Thalamus#Thalamic_nuclei" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010225 ; owl:annotatedTarget "A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]." . _:genid148173 oboInOwl:source "ZFA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010227 ; owl:annotatedTarget _:genid150072 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000926 . [] oboInOwl:hasDbXref "ZFA:0001718" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010227 ; owl:annotatedTarget "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." . [] oboInOwl:hasDbXref "ZFA:0001718" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010227 ; owl:annotatedTarget "presumptive atrium heart tube" . [] oboInOwl:hasDbXref "FMA:71005" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010227 ; owl:annotatedTarget "primordial atrium" . _:genid148177 oboInOwl:hasDbXref "FMA:71005" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010227 ; owl:annotatedTarget "primordial cardiac atrium" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001041 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget _:genid150079 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:16951553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002024 ; owl:annotatedTarget "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget "The core globe-shaped component of the camera-type eye." . [] oboInOwl:hasDbXref "VHOG:0001616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget "eye globe" . [] oboInOwl:hasDbXref "FMA:12513" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget "eyeball" . [] oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget "eye" . [] oboInOwl:hasDbXref "HP:0100886", "MIAA:0000283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010230 ; owl:annotatedTarget "globe" . (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006616 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006617 ] ) . ( ) . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010233 ; owl:annotatedTarget _:genid150097 . _:genid148196 oboInOwl:hasDbXref "http://www.drugs.com/dict/stroma-of-thyroid-gland.html" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010233 ; owl:annotatedTarget "The connective tissue that supports the lobules and follicles of the thyroid gland." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 . [] oboInOwl:hasDbXref "FMA:86304" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010233 ; owl:annotatedTarget "thyroid gland stroma" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget obo:UBERON_0000933 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget obo:UBERON_0003682 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget _:genid150103 . [] oboInOwl:notes "vagus nerve and cranial accessory nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget _:genid150105 . [] oboInOwl:notes "vagus nerve and cranial accessory nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget _:genid150107 . [] oboInOwl:notes "palatine aponeurosis and hard palate" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget _:genid150109 . [] oboInOwl:notes "Upper border of thyroid cartilage" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget _:genid150111 . [] oboInOwl:hasDbXref "Wikipedia:Palatopharyngeus_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "The palatopharyngeus or palatopharyngeal or pharyngopalatinus muscle is a long, fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the palatopharyngeal arch." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "Palatopharyngeus is a muscle that attaches to the palatine bones, soft palate, and pharynx and is innervated by Cranial Nerve X via the pharyngeal plexus.[FEED]" . [] oboInOwl:hasDbXref "FMA:46666" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "palatopharyngeus" . [] oboInOwl:hasDbXref "Wikipedia:Palatopharyngeus_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "pharyngopalatinus muscle" . [] oboInOwl:hasDbXref "Wikipedia:Palatopharyngeus_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "musculus palatopharyngeus" . [] oboInOwl:hasDbXref "Wikipedia:Palatopharyngeus_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010234 ; owl:annotatedTarget "pharyngopalatinus" . _:genid148216 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget obo:UBERON_0003682 ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003462 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget _:genid150124 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget _:genid150126 . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "The musculus uvulae (azygos uvulae) is a muscle of the soft palate. It arises from the posterior nasal spine of the palatine bones and from the palatine aponeurosis. It descends to be inserted into the uvula and functions to move and shape it. It is innervated by the pharyngeal branch of the vagus nerve via the pharyngeal plexus[WP]." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "The muscle of the uvuli is an integral part of the soft palate and is innervated by Cranial Nerve X .[FEED]" . [] oboInOwl:hasDbXref "FMA:46733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "uvular muscle" . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "azygos uvulae" . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "m. uvulae" . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "musculus uvulae" . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "musculus uvulae muscle" . [] oboInOwl:hasDbXref "Wikipedia:Musculus_uvulae" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010235 ; owl:annotatedTarget "uvulae muscle" . [] oboInOwl:hasDbXref "MGI:anna", "MP:0013544", "Wikipedia:Merocrine" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010243 ; owl:annotatedTarget "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." . _:genid148234 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001681, obo:UBERON_0009584 . [] oboInOwl:source "inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010252 ; owl:annotatedTarget obo:UBERON_0010259 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010252 ; owl:annotatedTarget _:genid150149 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010252 ; owl:annotatedTarget _:genid150151 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010252 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." . ( ) . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010253 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010253 ; owl:annotatedTarget _:genid150162 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010253 ; owl:annotatedTarget _:genid150164 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010253 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002027 ; owl:annotatedTarget obo:CL_0000556 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010254 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010254 ; owl:annotatedTarget _:genid150174 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010254 ; owl:annotatedTarget _:genid150176 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010254 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme." . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005690 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) . ( ) . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002027 ; owl:annotatedTarget "A megakaryocyte cell with is CD9-positive and CD41-positive." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget obo:UBERON_0007524 . _:genid148271 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget _:genid150187 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002539 . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget _:genid150189 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000571" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget "3rd pharyngeal arch mesenchyme derived from neural crest" . [] oboInOwl:hasDbXref "EMAPA:16404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010255 ; owl:annotatedTarget "mesenchyme derived from neural crest of mesenchyme of 3rd arch" . _:genid148281 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342, obo:UBERON_0004362 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget _:genid150202 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget _:genid150204 . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget _:genid150206 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000580" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget "4th pharyngeal arch mesenchyme derived from neural crest" . [] oboInOwl:hasDbXref "EMAPA:16772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010256 ; owl:annotatedTarget "mesenchyme derived from neural crest of mesenchyme of 4th arch" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010257 ; owl:annotatedTarget obo:UBERON_0007524 . _:genid148298 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010257 ; owl:annotatedTarget _:genid150219 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001723 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010257 ; owl:annotatedTarget _:genid150221 . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010257 ; owl:annotatedTarget _:genid150223 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010257 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010258 ; owl:annotatedTarget _:genid150230 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010258 ; owl:annotatedTarget "Mesenchyme that develops_from a rhombencephalon neural crest." . [] oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010259 ; owl:annotatedTarget _:genid150239 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010259 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." . [] oboInOwl:hasDbXref "EMAPA:16129" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010259 ; owl:annotatedTarget "mesenchyme derived from neural crest of mesenchyme of 1st arch" . [] oboInOwl:hasDbXref "MP:0003230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010260 ; owl:annotatedTarget "One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta." . [] oboInOwl:hasDbXref "Hymans:Hymans" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010260 ; owl:annotatedTarget "allantoic vessel" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010260 ; owl:annotatedTarget "umbilical cord blood vessels" . [] oboInOwl:hasDbXref "Wikipedia:Operculum_(brain)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010262 ; owl:annotatedTarget "The most posterior portion of the inferior frontal gyrus of the frontal lobe in the brain. In an axial plane, the Sylvian fissure extends from the operculum posteriorly to divide the frontal from the temporal lobe. Broca's area is a notable part of the operculum, which plays a key role in conversation or speech production, reading and writing. Its vascular supply comes from the M3 branches of the middle cerebral artery[WP]." . [] oboInOwl:hasDbXref "HP:0100954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010262 ; owl:annotatedTarget "operculum" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget _:genid150254 . [] oboInOwl:hasDbXref "http://www.biology-online.org/dictionary/Hyoid_apparatus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000225" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "Apparatus located in the floor of the mouth, under the mandibular arcade. The apparatus consists of a central corpus and four pairs of processes. This apparatus serves as the site of insertion for a variety of muscles associated with movements of the tongue and as the origin of the m. hyoglossus.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000225" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "relationship loss: part_of hyolaryngeal complex (AAO:0000226)[AAO]" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "EMAPA:37600" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "apparatus hyobranchialis" . [] oboInOwl:hasDbXref "http://www.biology-online.org/dictionary/Hyoid_apparatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "apparatus hyoideus" . [] oboInOwl:hasDbXref "AAO:0000225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "hyobranchial apparatus" . [] oboInOwl:hasDbXref "AAO:0000225" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010272 ; owl:annotatedTarget "hyolingual system" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010273 ; owl:annotatedTarget "A zone of bone organ that is part of a hyoid bone." . [] oboInOwl:hasDbXref "FMA:59494" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010273 ; owl:annotatedTarget "hyoid bone zone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010276 ; owl:annotatedTarget "Any anatomical space that is part of a vertebral column." . [] oboInOwl:hasDbXref "AAO:0000700" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010276 ; owl:annotatedTarget "vertebral column opening" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010284 ; owl:annotatedTarget obo:UBERON_0000161 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_punctum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010284 ; owl:annotatedTarget "A minute orifice on the summit of the papillae lacrimales, which is the commencement point of the lacrimal canaliculi." . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_punctum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010284 ; owl:annotatedTarget "lacrimal point" . _:genid148353 oboInOwl:hasDbXref "Wikipedia:Lacrimal_punctum" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010284 ; owl:annotatedTarget "lacrimal puncta" ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003099 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_punctum" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010284 ; owl:annotatedTarget "puncta lacrimalia" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget obo:UBERON_0002020 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget _:genid150283 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget _:genid150285 . [] oboInOwl:hasDbXref "ZFA:0000761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." . [] oboInOwl:hasDbXref "TAO:0000761" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget "basal plate midbrain" . [] oboInOwl:hasDbXref "ZFA:0000761" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010285 ; owl:annotatedTarget "basal plate midbrain region" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010286 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010286 ; owl:annotatedTarget _:genid150291 . _:genid148363 oboInOwl:hasDbXref "ZFA:0007039" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010286 ; owl:annotatedTarget "Portion of neural tube that gives rise to the midbrain." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003929 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010291 ; owl:annotatedTarget _:genid150294 . _:genid148365 oboInOwl:hasDbXref "Wikipedia:Sclera#Histology" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010291 ; owl:annotatedTarget "." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009550 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010294 ; owl:annotatedTarget obo:UBERON_0010291 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010294 ; owl:annotatedTarget "An endothelium that is part of a sclera." . _:genid148372 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003891 _:genid148374 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001444 . _:genid148374 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001773, obo:UBERON_0009477 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget obo:UBERON_0010291 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "A stroma that is part of a sclera." . [] oboInOwl:source "ncithesaurus:Substantia_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "UMLS:C1704397" . [] oboInOwl:hasDbXref "FMA:58365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "scleral stroma" . [] oboInOwl:hasDbXref "FMA:58365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "stroma of sclera" . [] oboInOwl:hasDbXref "FMA:58365" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "subsantia propria sclerae" . [] oboInOwl:hasDbXref "FMA:58365", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010295 ; owl:annotatedTarget "substantia propria sclerae" . [] oboInOwl:hasDbXref "PMID:16496288", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010299 ; owl:annotatedTarget "Mesenchyme surrounding the developing optic cup which develops into the sclera." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010303 ; owl:annotatedTarget "An epithelium that is part of a extraembryonic structure." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget obo:UBERON_0006915 . [] oboInOwl:hasDbXref "FMA:45569", "Wikipedia:Stratified_squamous_epithelium#Nonkeratinized" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget "Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus." . [] oboInOwl:hasDbXref "FMA:45569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget "epithelium stratificatum squamosum noncornificatum" . [] oboInOwl:hasDbXref "FMA:45569" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget "nonkeratinizing stratified squamous epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget "stratified squamous non-keratinized epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010304 ; owl:annotatedTarget "stratified squamous nonkeratinizing epithelium" . [] oboInOwl:hasDbXref "Wikipedia:Conjunctiva#Gross_anatomy" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010305 ; owl:annotatedTarget "One of the three major regions of the conjunctiva." . [] oboInOwl:hasDbXref "FMA:59023" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010305 ; owl:annotatedTarget "region of conjunctiva" . _:genid148407 a owl:Restriction ; owl:onProperty obo:RO_0000086, obo:RO_0002254 ; owl:someValuesFrom obo:PATO_0000964, obo:UBERON_0005689 . _:genid148409 a owl:Restriction ; owl:onProperty obo:RO_0002220, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0001773, obo:UBERON_0010045 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010306 ; owl:annotatedTarget obo:UBERON_0010305 . [] oboInOwl:hasDbXref "MP:0013402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010306 ; owl:annotatedTarget "The conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea." . [] oboInOwl:source "ncithesaurus:Bulbar_Conjunctiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010306 ; owl:annotatedTarget "UMLS:C0229275" . [] oboInOwl:hasDbXref "Wikipedia:Conjunctiva" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010306 ; owl:annotatedTarget "ocular conjunctiva" . [] oboInOwl:hasDbXref "PMID:16496288", "Wikipedia:Palpebral_(bone)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010309 ; owl:annotatedTarget "An ossified element investing the upper eyelid." . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010312 ; owl:annotatedTarget _:genid150354 . [] oboInOwl:hasDbXref "ZFA:0001678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010312 ; owl:annotatedTarget "Developing anatomical structure that develops into the eyeball and associated structures." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002201" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010312 ; owl:annotatedTarget "Multi-tissue structure that consists of the structures that develop into the retina and lens.[TAO]" . _:genid148430 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010313 ; owl:annotatedTarget "An anatomical structure that develops from the neural crest." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003413 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010314 ; owl:annotatedTarget "An anatomical structure that has some part that develops from the neural crest." . [] oboInOwl:source "GO", "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010316 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "PMID:16496288" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010321 ; owl:annotatedTarget _:genid150375 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010321 ; owl:annotatedTarget "A skeletal element that is part of a orbital region." . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000049", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010323 ; owl:annotatedTarget "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000109" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010323 ; owl:annotatedTarget "Bony structure that encases the central nervous system and the primary sense organs of sight, olfaction, hearing, and equilibrium.[AAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000737" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010323 ; owl:annotatedTarget "Skeletal system which is part of the skull, including the splanchnocranium, chondrocranium, and dermatocranium.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0000737" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010323 ; owl:annotatedTarget "cranium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010328 ; owl:annotatedTarget "Mesenchyme that is part of a limb bud." . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010329 ; owl:annotatedTarget _:genid150392 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010329 ; owl:annotatedTarget "Mesenchyme that is part of a limb/fin bud." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010330 ; owl:annotatedTarget "Mesenchyme that is part of a developing eyelid." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002028 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010332 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010332 ; owl:annotatedTarget _:genid150405 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010332 ; owl:annotatedTarget "An epithelium that is part of a handplate." . [] oboInOwl:hasDbXref "EHDAA2:0000730" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010332 ; owl:annotatedTarget "handplate epithelium" . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010333 ; owl:annotatedTarget _:genid150413 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010333 ; owl:annotatedTarget "Mesenchyme that is part of a extraembryonic membrane." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002028 ; owl:annotatedTarget "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" . _:genid148484 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0002529 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002544 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0004300 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0009768 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010334 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010334 ; owl:annotatedTarget _:genid150423 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010334 ; owl:annotatedTarget _:genid150425 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010334 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010335 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010335 ; owl:annotatedTarget _:genid150435 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010335 ; owl:annotatedTarget _:genid150437 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010335 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010336 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010336 ; owl:annotatedTarget _:genid150447 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010336 ; owl:annotatedTarget _:genid150449 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010336 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010337 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010337 ; owl:annotatedTarget _:genid150459 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010337 ; owl:annotatedTarget _:genid150461 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010337 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010338 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010338 ; owl:annotatedTarget _:genid150471 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010338 ; owl:annotatedTarget _:genid150473 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010338 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." . _:genid148532 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009551, obo:UBERON_0009584 . _:genid148534 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904, obo:UBERON_0011272 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010339 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010339 ; owl:annotatedTarget _:genid150483 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010339 ; owl:annotatedTarget _:genid150485 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010339 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 ] ) . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010341 ; owl:annotatedTarget obo:UBERON_0003104 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010341 ; owl:annotatedTarget _:genid150495 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010341 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." . [] oboInOwl:hasDbXref "EMAPA:16130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010341 ; owl:annotatedTarget "mesenchyme derived from head mesoderm of mesenchyme of 1st arch" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010343 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010343 ; owl:annotatedTarget _:genid150506 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010343 ; owl:annotatedTarget _:genid150508 . _:genid148559 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010343 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001262 . [] oboInOwl:hasDbXref "EMAPA:16280" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010343 ; owl:annotatedTarget "mesenchyme derived from head mesoderm of mesenchyme of 2nd arch" . _:genid148567 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010344 ; owl:annotatedTarget obo:UBERON_0007524 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005277 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010344 ; owl:annotatedTarget _:genid150519 . _:genid148569 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010344 ; owl:annotatedTarget _:genid150521 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009553 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010344 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme." . [] oboInOwl:hasDbXref "EMAPA:16403" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010344 ; owl:annotatedTarget "mesenchyme derived from head mesoderm of mesenchyme of 3rd arch" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010345 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010345 ; owl:annotatedTarget _:genid150532 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010345 ; owl:annotatedTarget _:genid150534 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010345 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme." . [] oboInOwl:hasDbXref "EMAPA:16771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010345 ; owl:annotatedTarget "mesenchyme derived from head mesoderm of mesenchyme of 4th arch" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010347 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010347 ; owl:annotatedTarget _:genid150545 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010347 ; owl:annotatedTarget _:genid150547 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010347 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010348 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010348 ; owl:annotatedTarget _:genid150551 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010349 ; owl:annotatedTarget "An otic capsule endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "DOI:10.1111/j.1469-7580.2005.00441.x", "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010354 ; owl:annotatedTarget _:genid150559 . [] oboInOwl:hasDbXref "EMAPA:17351" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010354 ; owl:annotatedTarget "hyoid cartilage pre-cartilage condensation" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:hasDbXref "Wikipedia:Ossification_center" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget "The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed a ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between two cells of the same row also becomes calcified, and transverse bars of calcified substance stretch across from one calcareous column to another. Thus there are longitudinal groups of the cartilage cells enclosed in oblong cavities, the walls of which are formed of calcified matrix which cuts off all nutrition from the cells; the cells, in consequence, atrophy, leaving spaces called the primary areolC&." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget "centrum ossificationis" . [] oboInOwl:hasDbXref "FMA:75436" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget "ossification centre" . [] oboInOwl:hasDbXref "Wikipedia:Ossification_center" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget "center of ossification" . [] oboInOwl:hasDbXref "Wikipedia:Ossification_center" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010355 ; owl:annotatedTarget "centrum ossificationis" . _:genid148609 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget _:genid150568 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005281 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "An arch-shaped structure of the vertebra that extends dorsally (neural arch) or ventrally (hemal arch) from the vertebral centrum." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001670" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.270", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "(...) certain common components [of vertebral structure] are found in nearly all vertebrate. A representative vertebra has a vertebral arch or neural arch, which extends dorsally around the spinal cord.[well established][VHOG]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "Note that humans do not have hemal arches, so VA=NA for FMA" . [] oboInOwl:hasDbXref "FMA:11946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "arch of vertebra" . [] oboInOwl:hasDbXref "FMA:11946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "arcus vertebrae (vertebralis)" . [] oboInOwl:hasDbXref "MA:0001453" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "vertebra arch" . [] oboInOwl:hasDbXref "FMA:11946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010358 ; owl:annotatedTarget "vertebral arch" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002029 ; owl:annotatedTarget obo:CL_0000831 . _:genid148621 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342, obo:UBERON_0009578 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010359 ; owl:annotatedTarget "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002029 ; owl:annotatedTarget "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010360 ; owl:annotatedTarget "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010362 ; owl:annotatedTarget obo:UBERON_0010912 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000037", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010362 ; owl:annotatedTarget "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." . [] oboInOwl:source "Wikipedia:Endoskeleton" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010362 ; owl:annotatedTarget "An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010362 ; owl:annotatedTarget "replacement skeleton" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010363 ; owl:annotatedTarget obo:UBERON_0004765 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000139", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010363 ; owl:annotatedTarget "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." . [] oboInOwl:hasDbXref "VSAO:0000139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010363 ; owl:annotatedTarget "endochondral replacement element" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget obo:UBERON_0010912 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000035", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." . [] oboInOwl:hasDbXref "VSAO:curator" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget "exoskeleton" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget "dermal skeletal system" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget "dermoskeleton" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010364 ; owl:annotatedTarget "desmoskeleton" . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000063", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "Classified as a portion of organism substance in FMA" . _:genid148654 oboInOwl:source "ncithesaurus:Tooth_Tissue" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "UMLS:C1519551" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007237 . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "odontogenic tissue" . [] oboInOwl:hasDbXref "FMA:63001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "portion of substance of tooth" . [] oboInOwl:hasDbXref "FMA:63001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "substance of tooth" . [] oboInOwl:hasDbXref "MA:0002540" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "tooth substance" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "dental tissue" . [] oboInOwl:hasDbXref "VT:0003930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010365 ; owl:annotatedTarget "tooth hard tissue" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010366 ; owl:annotatedTarget "A vasculature that is part of a conjunctiva." . [] oboInOwl:hasDbXref "FMA:70887" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010366 ; owl:annotatedTarget "conjunctival veins" . [] oboInOwl:hasDbXref "FMA:70887" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010366 ; owl:annotatedTarget "conjunctival veins set" . [] oboInOwl:hasDbXref "FMA:70887" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010366 ; owl:annotatedTarget "set of conjunctival veins" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010366 ; owl:annotatedTarget "venae conjunctivales" . (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001811 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010367 ; owl:annotatedTarget "A vein that is part of a conjunctiva." . _:genid148676 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0009911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002048 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003056 . ( ) . [] oboInOwl:hasDbXref "ncithesaurus:Pulmonary_Lobule" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010368 ; owl:annotatedTarget "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." . [] oboInOwl:hasDbXref "FMA:75739", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010368 ; owl:annotatedTarget "lobulus pulmonis" . _:genid148684 oboInOwl:source "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010370 ; owl:annotatedTarget obo:UBERON_0001638 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003056 . [] oboInOwl:hasDbXref "http://www.thefreedictionary.com/tibial+vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010370 ; owl:annotatedTarget "One of the veins of the lower leg; empty into the popliteal vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010370 ; owl:annotatedTarget "EMAPA:37199" . _:genid148687 oboInOwl:source "ncithesaurus:Tibial_Vein" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010370 ; owl:annotatedTarget "UMLS:C0447138" ; owl:intersectionOf (obo:UBERON_0003075 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007277 ] ) . _:genid148692 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:CL_0002077, obo:UBERON_0003057 . [] oboInOwl:hasDbXref "FMA:69064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010371 ; owl:annotatedTarget "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." . (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0009708 ] ) . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010375 ; owl:annotatedTarget _:genid150658 . [] oboInOwl:hasDbXref "FMA:79793" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010375 ; owl:annotatedTarget "dorsal pancreas" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010376 ; owl:annotatedTarget _:genid150665 . _:genid148705 oboInOwl:hasDbXref "FMA:79794" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010376 ; owl:annotatedTarget "ventral pancreas" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006238 . _:genid148708 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000922, obo:UBERON_0010286 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010377 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010377 ; owl:annotatedTarget _:genid150675 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010377 ; owl:annotatedTarget "Mesenchyme that develops_from a somatopleure." . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000922 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004873 ] ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010378 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010378 ; owl:annotatedTarget _:genid150685 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010378 ; owl:annotatedTarget "Mesenchyme that develops_from a splanchnopleure." . (obo:UBERON_0001135 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004773 ] ) . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget _:genid150692 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget _:genid150694 . [] oboInOwl:notes "underside of levator palpebrae superioris" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget _:genid150696 . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "The superior tarsal muscle is a smooth muscle adjoining the levator palpebrae superioris muscle that helps to raise the upper eyelid." . [] oboInOwl:hasDbXref "FMA:49058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "Mueller's muscle" . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "Muller's muscle" . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "Müller's muscle" . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "mueller muscle" . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "musculus tarsalis superior" . [] oboInOwl:hasDbXref "Wikipedia:Superior_tarsal_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010379 ; owl:annotatedTarget "the superior tarsal muscle" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0001046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010380 ; owl:annotatedTarget "The neurons that innervate the esophagus, stomach, small and large bowel." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010380 ; owl:annotatedTarget "EMAPA:37479" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002030 ; owl:annotatedTarget obo:CL_0000613 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010384 ; owl:annotatedTarget _:genid150716 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010384 ; owl:annotatedTarget "An anatomical space that is enclosed by a hypopharynx." . [] oboInOwl:hasDbXref "FMA:55096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010384 ; owl:annotatedTarget "laryngopharynx lumen" . _:genid148753 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002170 ; owl:someValuesFrom obo:UBERON_0001677, obo:UBERON_0002412 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010388 ; owl:annotatedTarget _:genid150721 . _:genid148755 oboInOwl:hasDbXref "MP:0000152", "PMID:15906248" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010388 ; owl:annotatedTarget "The segment of the rib that connects to a vertebra[MP]. a small part of the rib composed of the head, neck, tuberculum and a short proximal part of the body[PMID]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002241 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010388 ; owl:annotatedTarget "EMAPA:37495" . _:genid148757 oboInOwl:hasDbXref "PMID:15906248" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010388 ; owl:annotatedTarget "proximal part of rib" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002517 . [] oboInOwl:hasDbXref "MA:0001400" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010388 ; owl:annotatedTarget "proximal rib" . _:genid148759 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000464 _:genid148761 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009636 . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC1312421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002030 ; owl:annotatedTarget "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." . _:genid148761 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002572 ; owl:someValuesFrom obo:UBERON_0000057, obo:UBERON_0009640 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010390 ; owl:annotatedTarget "An organ cavity that is part of a urethra." . [] oboInOwl:hasDbXref "FMA:19709" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010390 ; owl:annotatedTarget "urethral lumen" . [] oboInOwl:hasDbXref "MP:0002345", "https://github.com/obophenotype/uberon/issues/6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010395 ; owl:annotatedTarget "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010399 ; owl:annotatedTarget _:genid150744 . [] oboInOwl:hasDbXref "MP:0002354", "Wikipedia:Trabecular_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010399 ; owl:annotatedTarget "One of the branches of the splenic artery[MP]." . [] oboInOwl:ontology "Wikipedia" ; oboInOwl:source "Wikipedia:Trabecular_arteries" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010399 ; owl:annotatedTarget "When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia]" . [] oboInOwl:source "ncithesaurus:Splenic_Trabecular_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010399 ; owl:annotatedTarget "UMLS:C1710159" . [] oboInOwl:hasDbXref "MP:0002228", "Wikipedia:Trabecular_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010400 ; owl:annotatedTarget "One of the veins that feed the splenic vein." . [] oboInOwl:ontology "Wikipedia" ; oboInOwl:source "Wikipedia:Trabecular_veins" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010400 ; owl:annotatedTarget "The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia]" . [] oboInOwl:source "ncithesaurus:Splenic_Trabecular_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010400 ; owl:annotatedTarget "UMLS:C1710160" . [] oboInOwl:hasDbXref "Wikipedia:Trabecular_veins" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010400 ; owl:annotatedTarget "trabecular vein" . [] oboInOwl:hasDbXref "MP:0001233", "PMID:10469309", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010402 ; owl:annotatedTarget "Any layer of the epidermis that is superior to the stratum basale." . [] oboInOwl:hasDbXref "MP:0001233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010402 ; owl:annotatedTarget "suprabasal layer" . [] oboInOwl:hasDbXref "MP:MP" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010408 ; owl:annotatedTarget "The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010408 ; owl:annotatedTarget "EMAPA:37673" . _:genid148801 oboInOwl:source "ncithesaurus:Angular_Artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010408 ; owl:annotatedTarget "UMLS:C0226116" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001231 . [] oboInOwl:hasDbXref "FMA:49583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010408 ; owl:annotatedTarget "angular artery" . _:genid148803 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019, obo:UBERON_0004810 . [] oboInOwl:hasDbXref "MP:0013754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010409 ; owl:annotatedTarget "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." . [] oboInOwl:hasDbXref "MA:0002486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010409 ; owl:annotatedTarget "eye surface" . [] oboInOwl:hasDbXref "MGI:csmith", "MP:0005337" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010411 ; owl:annotatedTarget "Encapsulated adipose tissue found on the dorsal side of the peritoneum." . (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001301 ] ) . [] oboInOwl:hasDbXref "MGI:csmith", "MGI:rbabiuk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010412 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the epididymis." . [] oboInOwl:hasDbXref "MP:0009288" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010412 ; owl:annotatedTarget "periepididymal fat pad" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002031 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010418 ; owl:annotatedTarget "An orifice that is part of a lower urinary tract." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010418 ; owl:annotatedTarget "urethral orifice" . _:genid148825 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010755 _:genid148827 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001901 . _:genid148827 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000029, obo:UBERON_0009644 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002031 ; owl:annotatedTarget "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget _:genid150799 . [] oboInOwl:hasDbXref "MP:MP", "PMID:25656706", "http://orcid.org/0000-0003-4183-8865", "https://github.com/obophenotype/uberon/issues/7", "https://orcid.org/0000-0001-9990-8331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "EMAPA:37661" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "lymph node B cell corona" . [] oboInOwl:hasDbXref "MA:0002990" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "lymph node follicular mantle" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "lymph node inactive zone" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "lymph node peripheral zone" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010420 ; owl:annotatedTarget "lymph node dark zone" . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget _:genid150813 . [] oboInOwl:hasDbXref "CL:tm", "PMID:17495967", "https://github.com/obophenotype/uberon/issues/6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes." . [] oboInOwl:hasDbXref "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "B cell domain of the spleen" . [] oboInOwl:hasDbXref "CL:tm", "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "lymphocytic corona" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "splenic corona" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "EMAPA:37962" . [] oboInOwl:hasDbXref "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "follicle mantle" . [] oboInOwl:hasDbXref "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "spleen B cell corona" . [] oboInOwl:hasDbXref "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "spleen B-cell corona" . [] oboInOwl:hasDbXref "CL:tm", "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "spleen lymphocytic corona" . [] oboInOwl:hasDbXref "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "splenic B cell corona" . [] oboInOwl:hasDbXref "CL:tm", "MP:0002360" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010421 ; owl:annotatedTarget "spleen mantle zone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010422 ; owl:annotatedTarget obo:UBERON_0000444 . [] oboInOwl:source "CL:tm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010422 ; owl:annotatedTarget _:genid150829 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010422 ; owl:annotatedTarget "A lymphoid follicle containing naive B cells." . [] oboInOwl:hasDbXref "FMA:55223" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010422 ; owl:annotatedTarget "primary lymphoid nodule" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010423 ; owl:annotatedTarget obo:UBERON_0010422 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010423 ; owl:annotatedTarget "A primary nodular lymphoid tissue that is part of a tonsil." . [] oboInOwl:hasDbXref "FMA:86018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010423 ; owl:annotatedTarget "lymphoid nodule of tonsil" . _:genid148867 oboInOwl:source "MA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010424 ; owl:annotatedTarget _:genid150840 ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0001179 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010424 ; owl:annotatedTarget "EMAPA:37492" . [] oboInOwl:hasDbXref "PMID:15906248" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010424 ; owl:annotatedTarget "distal part of rib" . [] oboInOwl:hasDbXref "MA:0001397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010424 ; owl:annotatedTarget "distal rib" . _:genid148871 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000003 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001707 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0006562 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009664 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010425 ; owl:annotatedTarget "A naris that is located inside the nasal cavity and connects to the pharynx." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010425 ; owl:annotatedTarget "choanae" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010425 ; owl:annotatedTarget "internal nares" . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_processes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." . [] oboInOwl:hasDbXref "FMA:76551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "ciliary processes" . [] oboInOwl:hasDbXref "FMA:76551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "ciliary processes set" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "processus ciliares" . [] oboInOwl:hasDbXref "FMA:76551" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "set of ciliary processes" . _:genid148886 oboInOwl:hasDbXref "Wikipedia:Ciliary_processes" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "ciliary process" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012465 . [] oboInOwl:hasDbXref "Wikipedia:Ciliary_processes" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010427 ; owl:annotatedTarget "processus ciliares" . _:genid148888 a owl:Restriction ; owl:onProperty obo:RO_0000086, obo:RO_0002202 ; owl:someValuesFrom obo:PATO_0000407, obo:UBERON_0009669 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010428 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002032 ; owl:annotatedTarget obo:CL_0000988 . [] oboInOwl:hasDbXref "Wikipedia:Flat_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010428 ; owl:annotatedTarget "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." . [] oboInOwl:source "ncithesaurus:Flat_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010428 ; owl:annotatedTarget "UMLS:C0222649" . _:genid148892 oboInOwl:hasDbXref "Wikipedia:Flat_bone" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010428 ; owl:annotatedTarget "os planum" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 . (obo:UBERON_0008593 obo:UBERON_0008594 ) . [] oboInOwl:source "MFMO-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget obo:UBERON_0001577 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget _:genid150872 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget _:genid150874 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Beilstein:3587154" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002032 ; owl:annotatedTarget "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget "One of: zygomaticus major, zygomaticus minor." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget "EMAPA:37703" . [] oboInOwl:source "ncithesaurus:Zygomaticus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget "UMLS:C1710708" . [] oboInOwl:hasDbXref "MA:0002404" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010437 ; owl:annotatedTarget "zygomaticus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010498 ; owl:annotatedTarget obo:UBERON_0000485 . [] oboInOwl:hasDbXref "Wikipedia:Pseudostratified_columnar_epithelium", "http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010498 ; owl:annotatedTarget "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010498 ; owl:annotatedTarget "glandular in NCIT; we consider the two NCIT terms synonymous" . [] oboInOwl:source "ncithesaurus:Pseudostratified_Columnar_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010498 ; owl:annotatedTarget "UMLS:C0836138" . [] oboInOwl:source "ncithesaurus:Pseudostratified_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010498 ; owl:annotatedTarget "UMLS:C1514590" . [] oboInOwl:hasDbXref "NCIT:NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010499 ; owl:annotatedTarget "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." . [] oboInOwl:source "ncithesaurus:Pseudostratified_Columnar_Ciliated_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010499 ; owl:annotatedTarget "UMLS:C0506992" . [] oboInOwl:hasDbXref "FMA:13146" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010499 ; owl:annotatedTarget "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010522 ; owl:annotatedTarget obo:UBERON_0004765 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010522 ; owl:annotatedTarget _:genid150893 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000135", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010522 ; owl:annotatedTarget "Skeletal element that forms as a replacement or substitution of another element or tissue." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010523 ; owl:annotatedTarget _:genid150896 . [] oboInOwl:hasDbXref "MESH:A07.231.432", "ZFA:0005251", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010523 ; owl:annotatedTarget "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." . [] oboInOwl:hasDbXref "TAO:0005251" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010523 ; owl:annotatedTarget "microcirculatory vessels" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010527 ; owl:annotatedTarget "An organ cavity that surrounded_by a bone." . [] oboInOwl:hasDbXref "FMA:24021" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010527 ; owl:annotatedTarget "bone organ cavity" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010528 ; owl:annotatedTarget obo:UBERON_0010527 . [] oboInOwl:hasDbXref "FMA:24028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010528 ; owl:annotatedTarget "air space of bone" . _:genid148931 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0009871, obo:UBERON_0010062 . _:genid148933 a owl:Restriction ; owl:onProperty obo:RO_0002256, obo:RO_0002285 ; owl:someValuesFrom obo:UBERON_0000084, obo:UBERON_0005625 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget _:genid150911 . [] oboInOwl:hasDbXref "http://www.embryology.ch/anglais/turinary/urinhaute03.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "." . [] oboInOwl:external_ontology "EMAPA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "different versions of EMAPA have different labels for the same classes. In vHOG this is part of metanephros cortex but this leads to a cycle in basic." . [] oboInOwl:hasDbXref "VHOG:0001241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "induced blastemal cells" . [] oboInOwl:hasDbXref "EMAPA:17953" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "nephrogenic interstitium of nephrogenic zone" . [] oboInOwl:hasDbXref "EMAPA:17645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "cap mesenchyme of metanephros of urinary system" . [] oboInOwl:hasDbXref "EMAPA:17953" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010531 ; owl:annotatedTarget "peripheral blastema" . _:genid148944 oboInOwl:source "EHDAA2-inferred" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010532 ; owl:annotatedTarget obo:UBERON_0003914 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010532 ; owl:annotatedTarget _:genid150923 . _:genid148946 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010532 ; owl:annotatedTarget "An epithelial tube that is fated to become a nephron." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003929 . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010532 ; owl:annotatedTarget "EHDAA2 treats this as already having a tubular structure, but in the ZFA representation this is a cluster of cells" . _:genid148948 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001225 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000081 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010533 ; owl:annotatedTarget _:genid150932 . _:genid148954 oboInOwl:hasDbXref "GO:0072214" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010533 ; owl:annotatedTarget "The metanephric cortex is the outer region of the metanephros[GO]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 . (obo:UBERON_0010532 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000080 ] ) . ( ) . [] oboInOwl:hasDbXref "GOC:cvs", "ZFA:0005584", "https://orcid.org/0000-0002-2244-7917" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010534 ; owl:annotatedTarget "Anatomical cluster which give rise to mature mesonephric nephrons. Zebrafish continously generate new mesonephric nephrons." . [] oboInOwl:hasDbXref "ZFA:0005584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010534 ; owl:annotatedTarget "developing mesonephric nephron" . _:genid148961 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010532 _:genid148963 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 . _:genid148963 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000081, obo:UBERON_0010376 . _:genid148965 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010535 ; owl:annotatedTarget _:genid150946 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003924 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010535 ; owl:annotatedTarget "A primitive nephron that is part of a metanephros." . [] oboInOwl:hasDbXref "EHDAA2:0001516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010535 ; owl:annotatedTarget "primitive nephron" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010536 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010536 ; owl:annotatedTarget _:genid150951 . _:genid148971 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010536 _:genid148973 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004706 . _:genid148973 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000080, obo:UBERON_0006567 . [] oboInOwl:hasDbXref "ZFA:0005587" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010537 ; owl:annotatedTarget "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010538 ; owl:annotatedTarget "An appendage segment that is part of a limb/fin." . _:genid148985 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0003328, obo:UBERON_0006566 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010540 ; owl:annotatedTarget _:genid150968 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010540 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a tarsal bone." . _:genid148994 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004067, obo:UBERON_0004454 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010541 ; owl:annotatedTarget _:genid150978 . _:genid148996 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010541 ; owl:annotatedTarget _:genid150980 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004068 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010541 ; owl:annotatedTarget _:genid150983 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010541 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a tarsal bone." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "CAS:7664-41-7" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002033 ; owl:annotatedTarget obo:CL_0001008 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010543 ; owl:annotatedTarget _:genid150990 . _:genid149007 oboInOwl:hasDbXref "VSAO:0005028", "VSAO:NI", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010543 ; owl:annotatedTarget "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003929 . [] oboInOwl:hasDbXref "FMA:231315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010543 ; owl:annotatedTarget "set of phalanges" . [] oboInOwl:hasDbXref "VSAO:0005028", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010543 ; owl:annotatedTarget "acropodium" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15572596", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002033 ; owl:annotatedTarget "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." . _:genid149010 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0004453 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000925 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget _:genid151003 . [] oboInOwl:notes "many to one" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget _:genid151005 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget obo:UBERON_0010545 . [] oboInOwl:hasDbXref "Wikipedia:Metacarpus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "The metacarpus is the intermediate part of the manus skeleton that is located between the phalanges (bones of the fingers) distally and the carpus which forms the connection to the forearm. The metacarpus consists of metacarpal bones. The metacarpals form a transverse arch to which the rigid row of distal carpal bones are fixed. The peripheral metacarpals (those of the thumb and little finger) form the sides of the cup of the palmar gutter and as they are brought together they deepen this concavity. The index metacarpal is the most firmly fixed, while the thumb metacarpal articulates with the trapezium and acts independently from the others. The middle metacarpals are tightly united to the carpus by intrinsic interlocking bone elements at their bases. The ring metacarpal forms a transitional element of the semi-independent last metacarpal. [WP,unvetted]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000946" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "Segment of the forearm corresponding to the metacarpus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "metacarpal bones" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "metacarpals [I-V]" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "metacarpals set" . [] oboInOwl:hasDbXref "FMA:71336", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "ossa metacarpalia [I-V]" . [] oboInOwl:hasDbXref "FMA:71336", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "ossa metacarpi [I-V]" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "set of metacarpal bones" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "set of metacarpals" . [] oboInOwl:hasDbXref "FMA:71336" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "set of metacarpals [I-V]" . [] oboInOwl:hasDbXref "VSAO:0005026", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "anterior metapodium" . [] oboInOwl:hasDbXref "AAO:0000946", "MA:th", "http://en.wiktionary.org/wiki/metapodial" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "fore metapodium" . [] oboInOwl:hasDbXref "Wikipedia:Metacarpus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010544 ; owl:annotatedTarget "metacarpalia" . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget _:genid151027 . [] oboInOwl:notes "many to one" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget _:genid151029 . [] oboInOwl:hasDbXref "Wikipedia:Metatarsus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "Limb segment that consists of the long bones of the pes. The metatarsals are analogous to the metacarpal bones of the manus." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000221" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "Segment of the leg corresponding to the metatarsus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" . [] oboInOwl:hasDbXref "FMA:71340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "metatarsal bones set" . [] oboInOwl:hasDbXref "FMA:71340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "metatarsals [I-V]" . [] oboInOwl:hasDbXref "FMA:71340", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "ossa metatarsalia [I-V]" . [] oboInOwl:hasDbXref "FMA:71340", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "ossa metatarsi[I-V]" . [] oboInOwl:hasDbXref "FMA:71340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "set of metatarsal bones" . [] oboInOwl:hasDbXref "FMA:71340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "set of metatarsals [I-V]" . [] oboInOwl:hasDbXref "Wikipedia:Metatarsus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "ossa metatarsalia" . [] oboInOwl:hasDbXref "VSAO:0005027", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010545 ; owl:annotatedTarget "posterior metapodium" . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget _:genid151047 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005025" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "Endochondral bone complex located between the mesopodium and the acropodium and consisting of the metacarpals or metatarsals.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005025" ; oboInOwl:ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005025" ; oboInOwl:ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" . [] oboInOwl:hasDbXref "VSAO:0005025" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "metapodial skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "metapodium skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "skeletal parts of metapodium" . [] oboInOwl:hasDbXref "VSAO:0005025", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010546 ; owl:annotatedTarget "metapodium" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010547 ; owl:annotatedTarget "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 1 mesenchyme." . _:genid149071 oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010547 ; owl:annotatedTarget "hind limb digit 1 metatarsal pre-cartilage condensation" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001004 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010547 ; owl:annotatedTarget "pedal digit I metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "EHDAA2:0002040" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010547 ; owl:annotatedTarget "toe 1 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010547 ; owl:annotatedTarget "foot digit 1 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010548 ; owl:annotatedTarget "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 2 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010548 ; owl:annotatedTarget "hind limb digit 2 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010548 ; owl:annotatedTarget "pedal digit II metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "EHDAA2:0002045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010548 ; owl:annotatedTarget "toe 2 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010548 ; owl:annotatedTarget "foot digit 2 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010549 ; owl:annotatedTarget "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 3 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010549 ; owl:annotatedTarget "hind limb digit 3 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010549 ; owl:annotatedTarget "pedal digit III metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "EHDAA2:0002050" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010549 ; owl:annotatedTarget "toe 3 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010549 ; owl:annotatedTarget "foot digit 3 metatarsal pre-cartilage condensation" . _:genid149097 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010550 ; owl:annotatedTarget "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 4 mesenchyme." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009669 . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010550 ; owl:annotatedTarget "hind limb digit 4 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010550 ; owl:annotatedTarget "pedal digit IV metatarsal pre-cartilage condensation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "CAS:7664-41-7" . [] oboInOwl:hasDbXref "EHDAA2:0002055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010550 ; owl:annotatedTarget "toe 4 metatarsal pre-cartilage condensation" . _:genid149101 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010550 ; owl:annotatedTarget "foot digit 4 metatarsal pre-cartilage condensation" ; owl:intersectionOf _:genid147268 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010551 ; owl:annotatedTarget "A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010551 ; owl:annotatedTarget "hind limb digit 5 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010551 ; owl:annotatedTarget "pedal digit V metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "EHDAA2:0002060" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010551 ; owl:annotatedTarget "toe 5 metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010551 ; owl:annotatedTarget "foot digit 5 metatarsal pre-cartilage condensation" . _:genid149113 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418, obo:UBERON_0003929 . _:genid149115 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003353, obo:UBERON_0010547 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010557 ; owl:annotatedTarget "A pedal digit metatarsal cartilage condensation that is part of a pedal digit 1 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010557 ; owl:annotatedTarget "hind limb digit 1 metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010557 ; owl:annotatedTarget "pedal digit I metatarsal cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010557 ; owl:annotatedTarget "foot digit 1 metatarsal cartilage element" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002034 ; owl:annotatedTarget obo:CL_0001008 . _:genid149124 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004902, obo:UBERON_0010548 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010558 ; owl:annotatedTarget "A pedal digit metatarsal cartilage element that is part of a pedal digit 2 mesenchyme." . _:genid149126 oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010558 ; owl:annotatedTarget "hind limb digit 2 metatarsal cartilage condensation" ; owl:onProperty obo:RO_0002256 ; owl:someValuesFrom obo:UBERON_0009845 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010558 ; owl:annotatedTarget "pedal digit II metatarsal cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010558 ; owl:annotatedTarget "foot digit 2 metatarsal cartilage element" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15572596", "PMID:17582345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002034 ; owl:annotatedTarget "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010559 ; owl:annotatedTarget "A pedal digit metatarsal cartilage element that is part of a pedal digit 3 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010559 ; owl:annotatedTarget "hind limb digit 3 metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010559 ; owl:annotatedTarget "pedal digit III metatarsal cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010559 ; owl:annotatedTarget "foot digit 3 metatarsal cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010560 ; owl:annotatedTarget "A pedal digit metatarsal cartilage element that is part of a pedal digit 4 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010560 ; owl:annotatedTarget "hind limb digit 4 metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010560 ; owl:annotatedTarget "pedal digit IV metatarsal cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010560 ; owl:annotatedTarget "foot digit 4 metatarsal cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010561 ; owl:annotatedTarget "A pedal digit metatarsal cartilage element that is part of a pedal digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010561 ; owl:annotatedTarget "hind limb digit 5 metatarsal cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010561 ; owl:annotatedTarget "pedal digit V metatarsal cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010561 ; owl:annotatedTarget "foot digit 5 metatarsal cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010562 ; owl:annotatedTarget "Mesenchyme that is part of a developing pedal digit 1." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010562 ; owl:annotatedTarget "hind limb digit 1 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010562 ; owl:annotatedTarget "pedal digit I mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010562 ; owl:annotatedTarget "foot digit 1 mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010564 ; owl:annotatedTarget "Mesenchyme that is part of a developing manual digit 1." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010564 ; owl:annotatedTarget "fore limb digit 1 mesenchyme" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010564 ; owl:annotatedTarget "manual digit I mesenchyme" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010564 ; owl:annotatedTarget "hand digit 1 mesenchyme" . (obo:UBERON_0015043 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010565 ; owl:annotatedTarget "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 1 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000515" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010565 ; owl:annotatedTarget "finger 1 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010565 ; owl:annotatedTarget "fore limb digit 1 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010565 ; owl:annotatedTarget "manual digit I metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010565 ; owl:annotatedTarget "hand digit 1 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010566 ; owl:annotatedTarget "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 2 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010566 ; owl:annotatedTarget "finger 2 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010566 ; owl:annotatedTarget "fore limb digit 2 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010566 ; owl:annotatedTarget "manual digit II metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010566 ; owl:annotatedTarget "hand digit 2 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010567 ; owl:annotatedTarget "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 3 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000527" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010567 ; owl:annotatedTarget "finger 3 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010567 ; owl:annotatedTarget "fore limb digit 3 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010567 ; owl:annotatedTarget "manual digit III metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010567 ; owl:annotatedTarget "hand digit 3 metacarpus pre-cartilage condensation" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "CAS:7664-41-7" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010568 ; owl:annotatedTarget "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 4 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000533" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010568 ; owl:annotatedTarget "finger 4 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010568 ; owl:annotatedTarget "fore limb digit 4 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010568 ; owl:annotatedTarget "manual digit IV metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010568 ; owl:annotatedTarget "hand digit 4 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010569 ; owl:annotatedTarget "A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 5 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000539" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010569 ; owl:annotatedTarget "finger 5 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010569 ; owl:annotatedTarget "fore limb digit 5 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010569 ; owl:annotatedTarget "manual digit V metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010569 ; owl:annotatedTarget "hand digit 5 metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010570 ; owl:annotatedTarget "A manual digit metacarpus cartilage element that is part of a manual digit 1 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000514" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010570 ; owl:annotatedTarget "finger 1 metacarpus cartilage element" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010570 ; owl:annotatedTarget "fore limb digit 1 metacarpus cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010570 ; owl:annotatedTarget "manual digit I metacarpus cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010570 ; owl:annotatedTarget "hand digit 1 metacarpus cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010571 ; owl:annotatedTarget "A manual digit metacarpus cartilage element that is part of a manual digit 2 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000520" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010571 ; owl:annotatedTarget "finger 2 metacarpus cartilage element" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010571 ; owl:annotatedTarget "fore limb digit 2 metacarpus cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010571 ; owl:annotatedTarget "manual digit II metacarpus cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010571 ; owl:annotatedTarget "hand digit 2 metacarpus cartilage element" . _:genid149237 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015045 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010572 ; owl:annotatedTarget "A manual digit metacarpus cartilage element that is part of a manual digit 3 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000526" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010572 ; owl:annotatedTarget "finger 3 metacarpus cartilage element" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010572 ; owl:annotatedTarget "fore limb digit 3 metacarpus cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010572 ; owl:annotatedTarget "manual digit III metacarpus cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010572 ; owl:annotatedTarget "hand digit 3 metacarpus cartilage element" . _:genid149247 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015046 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001225 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002035 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010573 ; owl:annotatedTarget "A manual digit metacarpus cartilage element that is part of a manual digit 4 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000532" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010573 ; owl:annotatedTarget "finger 4 metacarpus cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010573 ; owl:annotatedTarget "fore limb digit 4 metacarpus cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010573 ; owl:annotatedTarget "manual digit IV metacarpus cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010573 ; owl:annotatedTarget "hand digit 4 metacarpus cartilage element" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002035 ; owl:annotatedTarget "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010574 ; owl:annotatedTarget "A manual digit metacarpus cartilage element that is part of a manual digit 5 mesenchyme." . [] oboInOwl:hasDbXref "EHDAA2:0000538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010574 ; owl:annotatedTarget "finger 5 metacarpus cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010574 ; owl:annotatedTarget "fore limb digit 5 metacarpus cartilage element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010574 ; owl:annotatedTarget "manual digit V metacarpus cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010574 ; owl:annotatedTarget "hand digit 5 metacarpus cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010575 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit 1 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010575 ; owl:annotatedTarget "fore limb digit 1 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010575 ; owl:annotatedTarget "manual digit I phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010575 ; owl:annotatedTarget "hand digit 1 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010576 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit 2 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010576 ; owl:annotatedTarget "fore limb digit 2 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010576 ; owl:annotatedTarget "manual digit II phalanx pre-cartilage condensation" . _:genid149282 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010576 ; owl:annotatedTarget "hand digit 2 phalanx pre-cartilage condensation" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003081 . (obo:UBERON_0015027 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010577 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit 3 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010577 ; owl:annotatedTarget "fore limb digit 3 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010577 ; owl:annotatedTarget "manual digit III phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010577 ; owl:annotatedTarget "hand digit 3 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010578 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit 4 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010578 ; owl:annotatedTarget "fore limb digit 4 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010578 ; owl:annotatedTarget "manual digit IV phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010578 ; owl:annotatedTarget "hand digit 4 phalanx pre-cartilage condensation" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Drug_Central:4625" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010579 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010579 ; owl:annotatedTarget "fore limb digit 5 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010579 ; owl:annotatedTarget "manual digit V phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010579 ; owl:annotatedTarget "hand digit 5 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010580 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit 1 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010580 ; owl:annotatedTarget "hind limb digit 1 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010580 ; owl:annotatedTarget "pedal digit I phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010580 ; owl:annotatedTarget "foot digit 1 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010581 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit 2 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010581 ; owl:annotatedTarget "hind limb digit 2 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010581 ; owl:annotatedTarget "pedal digit II phalanx pre-cartilage condensation" . _:genid149322 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010581 ; owl:annotatedTarget "foot digit 2 phalanx pre-cartilage condensation" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009913 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010582 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit 3 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010582 ; owl:annotatedTarget "hind limb digit 3 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010582 ; owl:annotatedTarget "pedal digit III phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010582 ; owl:annotatedTarget "foot digit 3 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010583 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit 4 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010583 ; owl:annotatedTarget "hind limb digit 4 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010583 ; owl:annotatedTarget "pedal digit IV phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010583 ; owl:annotatedTarget "foot digit 4 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010584 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010584 ; owl:annotatedTarget "hind limb digit 5 phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010584 ; owl:annotatedTarget "pedal digit V phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010584 ; owl:annotatedTarget "foot digit 5 phalanx pre-cartilage condensation" . _:genid149351 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010585 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a pedal digit mesenchyme." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002113 . [] oboInOwl:hasDbXref "VHOG:0000952" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010585 ; owl:annotatedTarget "foot phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010585 ; owl:annotatedTarget "hind limb digit phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010585 ; owl:annotatedTarget "foot digit phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010586 ; owl:annotatedTarget "A pre-cartilage condensation that is part of a manual digit mesenchyme." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002036 ; owl:annotatedTarget obo:CL_0000837 . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010586 ; owl:annotatedTarget "fore limb digit phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "VHOG:0000954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010586 ; owl:annotatedTarget "hand phalanx pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010586 ; owl:annotatedTarget "hand digit phalanx pre-cartilage condensation" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010675 ; owl:annotatedTarget "A cartilage element that is part of a manual digit 1 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010675 ; owl:annotatedTarget "fore limb digit 1 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002036 ; owl:annotatedTarget "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010675 ; owl:annotatedTarget "manual digit I phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010675 ; owl:annotatedTarget "hand digit 1 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010676 ; owl:annotatedTarget "A cartilage element that is part of a manual digit 2 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010676 ; owl:annotatedTarget "fore limb digit 2 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010676 ; owl:annotatedTarget "manual digit II phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010676 ; owl:annotatedTarget "hand digit 2 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010677 ; owl:annotatedTarget "A cartilage element that is part of a manual digit 3 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010677 ; owl:annotatedTarget "fore limb digit 3 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010677 ; owl:annotatedTarget "manual digit III phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010677 ; owl:annotatedTarget "hand digit 3 phalanx cartilage element" . (obo:UBERON_0015028 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010678 ; owl:annotatedTarget "A cartilage element that is part of a manual digit 4 mesenchyme." . _:genid149396 oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010678 ; owl:annotatedTarget "fore limb digit 4 phalanx cartilage condensation" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010678 ; owl:annotatedTarget "manual digit IV phalanx cartilage element" . _:genid149398 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010678 ; owl:annotatedTarget "hand digit 4 phalanx cartilage element" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009844 . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Gmelin:79" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010679 ; owl:annotatedTarget "A cartilage element that is part of a manual digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010679 ; owl:annotatedTarget "fore limb digit 5 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010679 ; owl:annotatedTarget "manual digit V phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010679 ; owl:annotatedTarget "hand digit 5 phalanx cartilage element" . (obo:UBERON_0015031 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010680 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit 1 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010680 ; owl:annotatedTarget "hind limb digit 1 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010680 ; owl:annotatedTarget "pedal digit I phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010680 ; owl:annotatedTarget "foot digit 1 phalanx cartilage element" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010681 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit 2 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010681 ; owl:annotatedTarget "hind limb digit 2 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010681 ; owl:annotatedTarget "pedal digit II phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010681 ; owl:annotatedTarget "foot digit 2 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010682 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit 3 mesenchyme." . _:genid149432 oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010682 ; owl:annotatedTarget "hind limb digit 3 phalanx cartilage condensation" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010682 ; owl:annotatedTarget "pedal digit III phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010682 ; owl:annotatedTarget "foot digit 3 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010683 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit 4 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010683 ; owl:annotatedTarget "hind limb digit 4 phalanx cartilage condensation" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010683 ; owl:annotatedTarget "pedal digit IV phalanx cartilage element" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010683 ; owl:annotatedTarget "foot digit 4 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010684 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit 5 mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010684 ; owl:annotatedTarget "hind limb digit 5 phalanx cartilage condensation" . _:genid149451 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010684 ; owl:annotatedTarget "pedal digit V phalanx cartilage element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004406 . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010684 ; owl:annotatedTarget "foot digit 5 phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010685 ; owl:annotatedTarget "A cartilage element that is part of a pedal digit mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010685 ; owl:annotatedTarget "hind limb digit phalanx cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010685 ; owl:annotatedTarget "foot digit phalanx cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010686 ; owl:annotatedTarget "A cartilage element that is part of a manual digit mesenchyme." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010686 ; owl:annotatedTarget "fore limb digit phalanx cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010686 ; owl:annotatedTarget "hand digit phalanx cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010687 ; owl:annotatedTarget "hind limb digit metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "VHOG:0000948" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010687 ; owl:annotatedTarget "metatarsus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010687 ; owl:annotatedTarget "foot digit metatarsal pre-cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:32956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010687 ; owl:annotatedTarget "metatarsal pre-cartilage condensation" . _:genid149479 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398, obo:UBERON_0003946 . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget _:genid151474 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget obo:UBERON_0010696 . [] oboInOwl:hasDbXref "VSAO:0005029", "VSAO:NI", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified]." . [] oboInOwl:hasDbXref "VSAO:0005029", "VSAO:NI" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget "manual phalanges" . [] oboInOwl:hasDbXref "FMA:71337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget "phalanges of hand" . [] oboInOwl:hasDbXref "FMA:71337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget "set of phalanges of hand" . [] oboInOwl:hasDbXref "VSAO:0005029", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010688 ; owl:annotatedTarget "anterior acropodium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002043 ; owl:annotatedTarget obo:CL_0000837 . _:genid149493 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010690 ; owl:annotatedTarget "An epithelium that is part of a manual digit 1." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000454 . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010690 ; owl:annotatedTarget "fore limb digit 1 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010690 ; owl:annotatedTarget "manual digit I epithelium" . _:genid149496 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010690 ; owl:annotatedTarget "hand digit 1 epithelium" ; owl:onProperty obo:RO_0002131 ; owl:someValuesFrom obo:UBERON_0001893 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:110589" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18371405", "PMID:19022770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002043 ; owl:annotatedTarget "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010693 ; owl:annotatedTarget "An epithelium that is part of a pedal digit 1." . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010693 ; owl:annotatedTarget "hind limb digit 1 epithelium" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010693 ; owl:annotatedTarget "pedal digit I epithelium" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010693 ; owl:annotatedTarget "foot digit 1 epithelium" . _:genid149509 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010695 ; owl:annotatedTarget "Mesenchyme of the carpal region that contributes to the tarsal skeleton." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 . (obo:UBERON_0010543 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) . [] oboInOwl:source "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget _:genid151508 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm]." . [] oboInOwl:hasDbXref "VSAO:0005030", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget "pedal phalanges" . [] oboInOwl:hasDbXref "FMA:78512" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget "phalanges of foot" . [] oboInOwl:hasDbXref "FMA:78512" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget "set of phalanges of foot" . [] oboInOwl:hasDbXref "VSAO:0005030", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010696 ; owl:annotatedTarget "posterior acropodium" . (obo:UBERON_0015036 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010697 ; owl:annotatedTarget "hind limb digit metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010697 ; owl:annotatedTarget "foot digit metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:32951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010697 ; owl:annotatedTarget "metatarsal cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010698 ; owl:annotatedTarget "fore limb digit metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "VHOG:0000953" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010698 ; owl:annotatedTarget "metacarpal bone pre-cartilage condensation" . [] oboInOwl:hasDbXref "VHOG:0000953" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010698 ; owl:annotatedTarget "metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010698 ; owl:annotatedTarget "hand digit metacarpus pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:accepted" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010699 ; owl:annotatedTarget "fore limb digit metacarpus cartilage element" . _:genid149543 oboInOwl:hasDbXref "NCBITaxon:9606", "OBOL:accepted" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010699 ; owl:annotatedTarget "hand digit metacarpus cartilage element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009471 . [] oboInOwl:hasDbXref "EMAPA:32849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010699 ; owl:annotatedTarget "metacarpal cartilage condensation" . _:genid149545 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003114 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010700 ; owl:annotatedTarget _:genid151544 . [] oboInOwl:hasDbXref "EMAPA:32721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010701 ; owl:annotatedTarget "phalanx cartilage condensation" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010702 ; owl:annotatedTarget "Mesenchyme of the digit region." . [] oboInOwl:hasDbXref "NCIT:C34141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010702 ; owl:annotatedTarget "digital ray" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget obo:UBERON_0010720 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "The collection of all skeletal elements in an forelimb zeugopod region." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000200" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "Segment of the forearm corresponding to the radius and ulna.[AAO]" . [] oboInOwl:hasDbXref "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "antebrachium skeleton" . [] oboInOwl:hasDbXref "VSAO:0005011", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "anterior zeugopodium skeleton" . [] oboInOwl:hasDbXref "FMA:71199" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "forearm skeleton" . [] oboInOwl:hasDbXref "FMA:71199" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "skeleton of forearm" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "wing zeugopod skeleton" . [] oboInOwl:hasDbXref "VSAO:0005011", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "anterior zeugopodium" . [] oboInOwl:hasDbXref "AAO:0000200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "fore epipodium" . [] oboInOwl:hasDbXref "VSAO:0005011", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "forelimb epipodium" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010703 ; owl:annotatedTarget "mesomere 2 of pectoral appendage" . _:genid149580 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0000468, obo:UBERON_0008814 . _:genid149582 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003099 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000214" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "VSAO:0000214" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region)" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "EMAPA:37858" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "appendage complex" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "appendage-girdle complex" . [] oboInOwl:hasDbXref "VSAO:0000214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "appendage/girdle complex" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "girdle plus limb or fin" . [] oboInOwl:hasDbXref "FMA:7182" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010707 ; owl:annotatedTarget "limb" . [] oboInOwl:hasDbXref "VSAO:0000213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000213" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "Appendage girdle complex that when present, encompasses the pectoral appendage and half of the pectoral girdle.[VSAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:11139349" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "EMAPA:37860" . [] oboInOwl:hasDbXref "VSAO:0000213" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "pectoral appendage/girdle complex" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "pectoral girdle plus anterior limb or fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "pectoral girdle plus pectoral limb or fin" . [] oboInOwl:hasDbXref "FMA:7183" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "upper limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "upper limb and pectoral girdle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010708 ; owl:annotatedTarget "upper limb and shoulder" . [] oboInOwl:hasDbXref "VSAO:0000215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000215" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "Appendage girdle complex that when present, encompasses the pelvic appendage and the pelvic girdle.[VSAO]" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region). Note the MA class 'hindlimb' may also belong here" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "EMAPA:37863" . [] oboInOwl:hasDbXref "VSAO:0000215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "pelvic appendage/girdle complex" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "pelvic girdle plus pelvic limb or fin" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "pelvic girdle plus posterior limb or fin" . [] oboInOwl:hasDbXref "FMA:7184" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "lower limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "lower limb and pelvic girdle" . _:genid149621 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010709 ; owl:annotatedTarget "lower limb and pelvis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010056 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010712 ; owl:annotatedTarget _:genid151622 . [] oboInOwl:hasDbXref "VSAO:0005018", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010712 ; owl:annotatedTarget "Skeletal subdivision that is a segment of the limb skeleton." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002044 ; owl:annotatedTarget obo:CL_0002028 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010714 ; owl:annotatedTarget obo:UBERON_0005863 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010714 ; owl:annotatedTarget _:genid151630 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010714 ; owl:annotatedTarget _:genid151632 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010714 ; owl:annotatedTarget "An iliac endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EMAPA:18347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010714 ; owl:annotatedTarget "iliac cartilage condensation" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002044 ; owl:annotatedTarget "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010718 ; owl:annotatedTarget obo:UBERON_0005863 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010718 ; owl:annotatedTarget _:genid151641 . _:genid149643 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010718 ; owl:annotatedTarget _:genid151643 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010718 ; owl:annotatedTarget "A pubic endochondral element that is composed primarily of cartilage tissue." . _:genid149645 oboInOwl:hasDbXref "EMAPA:26928" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010718 ; owl:annotatedTarget "pubic cartilage condensation" ; owl:onProperty obo:RO_0002225 ; owl:someValuesFrom obo:UBERON_0010020 . _:genid149650 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756, obo:UBERON_0002091 . _:genid149653 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010719 ; owl:annotatedTarget "The subdivision of the skeleton of either the pectoral or pelvic girdle." ; owl:onProperty obo:RO_0002225 ; owl:someValuesFrom obo:UBERON_0010020 . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000302" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010719 ; owl:annotatedTarget "Skeletal subdivision that is part of the appendage girdle region.[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000302" ; oboInOwl:ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0010719 ; owl:annotatedTarget "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: part_of subdivision of skeleton (UBERON:0010912)[VSAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000302" ; oboInOwl:ontology "VSAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0010719 ; owl:annotatedTarget "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: proximally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" . _:genid149659 a owl:Restriction ; owl:onProperty obo:RO_0002170, obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0000464, obo:UBERON_0003823 . _:genid149663 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "Subdivision of skeleton consisting of all skeletal elements in an hindlimb zeugopod region. Typically consists of the tibia and the fibula." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001691 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000216" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "Segment of the leg corresponding to the tibia and fibula.[AAO]" . _:genid149665 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "crural skeleton" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005872 . [] oboInOwl:hasDbXref "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "crus skeleton" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "skeleton cruris" . [] oboInOwl:hasDbXref "AAO:0000216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "hind epipodium" . [] oboInOwl:hasDbXref "VSAO:0005014", "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "hindlimb epipodium" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "mesomere 2 of pelvic appendage" . [] oboInOwl:hasDbXref "VSAO:0005014" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010720 ; owl:annotatedTarget "posterior zeugopodium" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:hasDbXref "Wikipedia:Cuneiform_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget "There are three cuneiform bones in the human foot: the medial cuneiform the intermediate cuneiform also known as the middle the lateral cuneiform. They are located between the navicular bone and the first, second and third metatarsal bones and are medial to the cuboid bone[WP, unvetted, human specific]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000914" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget "Series of elements that articulate with the metatarsals.[AAO]" . [] oboInOwl:source "ncithesaurus:Cuneiform_Bone_of_the_Foot" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget "UMLS:C1511560" . [] oboInOwl:hasDbXref "FMA:24517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget "cuneiform bone" . [] oboInOwl:hasDbXref "AAO:0000914" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010721 ; owl:annotatedTarget "distal tarsal" . (obo:UBERON_0015059 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) . ( ) . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010728 ; owl:annotatedTarget obo:UBERON_0005866 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010728 ; owl:annotatedTarget _:genid151691 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010728 ; owl:annotatedTarget _:genid151693 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010728 ; owl:annotatedTarget "An orbitosphenoid endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:11540049" . [] oboInOwl:hasDbXref "VSAO:0005055" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "Endochondral tarsal bone articulating with centralia and metatarsal 4." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000932" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "Small element that articulates anteriorly with metatarsal IV. It may be absent in some taxa.[AAO]" . [] oboInOwl:hasDbXref "VSAO:0005055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "distal tarsal 4" . [] oboInOwl:hasDbXref "AAO:0000932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "tarsal 4" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "os tarsale IV" . [] oboInOwl:hasDbXref "VSAO:0005055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "cuboideum" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010737 ; owl:annotatedTarget "os cuboideum" . _:genid149716 oboInOwl:hasDbXref "VSAO:0005056" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010738 ; owl:annotatedTarget "Endochondral tarsal bone articulating with centralia and metatarsal 5." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000933" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Francis_1934" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010738 ; owl:annotatedTarget "Small element that articulates anteriorly with metatarsal V. It may be absent in some taxa.[AAO]" . _:genid149718 oboInOwl:hasDbXref "VSAO:0005056" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010738 ; owl:annotatedTarget "distal tarsal 5" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 . [] oboInOwl:hasDbXref "AAO:0000933" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010738 ; owl:annotatedTarget "tarsal 5" . _:genid149720 oboInOwl:hasDbXref "VSAO:0005056" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010738 ; owl:annotatedTarget "cuboideum" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004016 . [] oboInOwl:notes "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010740 ; owl:annotatedTarget _:genid151728 . _:genid149727 oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010740 ; owl:annotatedTarget "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002323 . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010740 ; owl:annotatedTarget "bone of extended limb/fin region" . _:genid149729 oboInOwl:hasDbXref "MA:0000688", "UBERONREF:0000003" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010740 ; owl:annotatedTarget "limb bone" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005594 . (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010741 ; owl:annotatedTarget "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010741 ; owl:annotatedTarget "note that the MA class includes girdle parts so it belongs here;" . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010741 ; owl:annotatedTarget "wing bone" . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010741 ; owl:annotatedTarget "bone of forelimb or pectoral fin or pectoral girdle" . [] oboInOwl:hasDbXref "MA:0000612", "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010741 ; owl:annotatedTarget "forelimb bone" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010742 ; owl:annotatedTarget obo:UBERON_0010740 . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010742 ; owl:annotatedTarget "A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010742 ; owl:annotatedTarget "the MA class called 'hindlimb bone' belongs here, as it includes bones in the pelvic girdle" . [] oboInOwl:hasDbXref "MA:0000660", "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010742 ; owl:annotatedTarget "hindlimb bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010743 ; owl:annotatedTarget "The collection of all meningeal layers that line a central nervous system." . [] oboInOwl:hasDbXref "FMA:231572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010743 ; owl:annotatedTarget "cluster of meninges" . [] oboInOwl:hasDbXref "FMA:231572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010743 ; owl:annotatedTarget "meninges" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010744 ; owl:annotatedTarget "A sacral vertebra endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "EHDAA2:0001774" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010744 ; owl:annotatedTarget "sacral vertebral pre-cartilage condensation group" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010745 ; owl:annotatedTarget _:genid151773 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010745 ; owl:annotatedTarget "A sacral vertebra endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0001773" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010745 ; owl:annotatedTarget "sacral vertebral cartilage condensation group" . _:genid149772 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001273, obo:UBERON_0005254 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:hasDbXref "PHENOSCAPE:ad", "https://github.com/obophenotype/uberon/issues/69" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "The extension of the ilium above the level of the acetabulum. Attachment site for both hindlimb and caudal musculature. Medially is the site of attachment of the sacral ribs, where these exist[PHENOSCAPE:ad]." . [] oboInOwl:source "ad" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "Often dorsally expanded in amniotes" . [] oboInOwl:hasDbXref "Wikipedia:Wing_of_ilium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "a. ossis ilii" . [] oboInOwl:hasDbXref "FMA:42826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "ala of ilium" . [] oboInOwl:hasDbXref "FMA:TA", "Wikipedia:Wing_of_ilium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "ala ossis ilii" . [] oboInOwl:hasDbXref "FMA:42826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "ilium ala" . [] oboInOwl:hasDbXref "Wikipedia:Wing_of_ilium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010746 ; owl:annotatedTarget "wing of the ilium" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010747 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:hasDbXref "Wikipedia:Body_of_ilium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010747 ; owl:annotatedTarget "The body of ilium enters into the formation of the acetabulum, of which it forms rather less than two-fifths. Its external surface is partly articular, partly non-articular; the articular segment forms part of the lunate surface of the acetabulum, the non-articular portion contributes to the acetabular fossa. The internal surface of the body is part of the wall of the lesser pelvis and gives origin to some fibers of the Obturator internus. Below, it is continuous with the pelvic surfaces of the ischium and pubis, only a faint line indicating the place of union." . [] oboInOwl:hasDbXref "FMA:42825" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010747 ; owl:annotatedTarget "ilium body" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_ilium" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010747 ; owl:annotatedTarget "corpus ossis ilii" . [] oboInOwl:notes "issues/7" ; oboInOwl:source "MP-def" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010748 ; owl:annotatedTarget _:genid151795 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010748 ; owl:annotatedTarget "A lymphoid follicle that is part of a lymph node." . [] oboInOwl:source "EHDAA2", "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010751 ; owl:annotatedTarget _:genid151802 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:11746427" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010753 ; owl:annotatedTarget obo:UBERON_0010748 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010753 ; owl:annotatedTarget "A secondary follicle that is located in a lymph node." . [] oboInOwl:hasDbXref "CL:tm", "Wikipedia:Germinal_center", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center." . [] oboInOwl:source "ncithesaurus:Germinal_Center" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "UMLS:C0282491" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "central zone of follice" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "reaction center of follicle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002045 ; owl:annotatedTarget obo:CL_0000826 . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "light zone of follicle" . _:genid149811 oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "lymhpoid nodule" ; owl:intersectionOf (obo:UBERON_0005295 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009117 ] ) . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010754 ; owl:annotatedTarget "nodule" . ( ) . [] oboInOwl:hasDbXref "CL:tm", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010755 ; owl:annotatedTarget "The part of the secondary follicle that surrounds the germinal center." . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:12633665", "PMID:17582343", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002045 ; owl:annotatedTarget "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." . [] oboInOwl:source "ncithesaurus:Mantle_Zone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010755 ; owl:annotatedTarget "UMLS:C1512987" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010755 ; owl:annotatedTarget "inactive zone of follicle" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010755 ; owl:annotatedTarget "peripheral zone of follicle" . [] oboInOwl:hasDbXref "CL:tm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010755 ; owl:annotatedTarget "dark zone of follicle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010758 ; owl:annotatedTarget "A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg." . [] oboInOwl:hasDbXref "FBbt:00007018" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010758 ; owl:annotatedTarget "appendage segment" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010760 ; owl:annotatedTarget obo:UBERON_0005813 . [] oboInOwl:hasDbXref "Wikipedia:Supraglenoid_tubercle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010760 ; owl:annotatedTarget "The supraglenoid tubercle is a region of the scapula to which the long head of the biceps brachii muscle attaches." . [] oboInOwl:hasDbXref "FMA:23263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010760 ; owl:annotatedTarget "supraglenoid tuberosity" . [] oboInOwl:hasDbXref "Wikipedia:Supraglenoid_tubercle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010760 ; owl:annotatedTarget "tuberculum supraglenoidale" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010801 ; owl:annotatedTarget "A calcaneum endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010842 ; owl:annotatedTarget "A calcaneum endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010843 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a clavicle." . [] oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0010843 ; owl:annotatedTarget "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010844 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a clavicle." . [] oboInOwl:source "ISBN:978-0-12-319060-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0010844 ; owl:annotatedTarget "In most birds and mammals the clavicles are the only dermal elements in the trunk, and is the only membrane bone associated with the pectoral girdle in these taxa. However, there can be secondary cartilage, or subsequent endochondral ossification, or fusion with endochondral elements. In rodents, the lateral ends of the clavicle are endochondral but the main portion is dermal." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010846 ; owl:annotatedTarget _:genid151871 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010846 ; owl:annotatedTarget _:genid151874 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010846 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a radius bone." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010847 ; owl:annotatedTarget _:genid151881 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010847 ; owl:annotatedTarget _:genid151884 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010847 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a ulna." . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010848 ; owl:annotatedTarget _:genid151891 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010848 ; owl:annotatedTarget "A radius-ulna endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010848 ; owl:annotatedTarget "note that this is not represented as a single unit in EHDAA2" . [] oboInOwl:hasDbXref "EMAPA:17711" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010848 ; owl:annotatedTarget "radio-ulna cartilage condensation" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010849 ; owl:annotatedTarget _:genid151902 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010849 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a tibia." . _:genid149894 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005866 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0000979 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007812 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010850 ; owl:annotatedTarget _:genid151911 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:11783653" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010850 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a tibia." . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010851 ; owl:annotatedTarget _:genid151920 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010851 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a fibula." . [] oboInOwl:hasDbXref "EMAPA:18154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010851 ; owl:annotatedTarget "fibulal cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:18154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010851 ; owl:annotatedTarget "fibular cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:18154" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010851 ; owl:annotatedTarget "fibulra cartilage condensation" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010852 ; owl:annotatedTarget _:genid151932 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010852 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a fibula." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002047 ; owl:annotatedTarget obo:CL_0002400 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010879 ; owl:annotatedTarget "A calcareous tooth that is elongated and protrudes from the mouth." . [] oboInOwl:source "Wikipedia:Tusk" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010879 ; owl:annotatedTarget "Elongated, continuously growing front teeth, usually but not always in pairs, that protrude well beyond the mouth of certain mammal species. They are most commonly canines, as with warthogs, pig, and walruses, or, in the case of elephants and narwhals, elongated incisors. In most tusked species both the males and the females have tusks although the males are larger. Tusks are generally curved, though the narwhal's sole tusk is straight and has a helical structure. In the elephant, the tusks were originally second incisors. Continuous growth is enabled by formative tissues in the apical oproperty_value external_definitionof the roots of the teeth" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:tfm", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002047 ; owl:annotatedTarget "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010881 ; owl:annotatedTarget "A skeletal element that is part of a limb and composed of cartilage tissue." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010882 ; owl:annotatedTarget "A skeletal element that is part of a limb and composed of pre-cartilage tissue." . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010883 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a forelimb bone." . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010883 ; owl:annotatedTarget "forelimb wing cartilaginous condensation" . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010883 ; owl:annotatedTarget "wing cartilaginous condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010884 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a forelimb bone." . [] oboInOwl:hasDbXref "NCBITaxon:8782", "OBOL:automatic" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010884 ; owl:annotatedTarget "wing bone pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010885 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a hindlimb bone." . [] oboInOwl:hasDbXref "EMAPA:32632" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010885 ; owl:annotatedTarget "hindlimb cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010886 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a hindlimb bone." . [] oboInOwl:hasDbXref "EMAPA:32638" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010886 ; owl:annotatedTarget "hindlimb pre-cartilage condensation" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010887 ; owl:annotatedTarget _:genid151981 . [] oboInOwl:source "Wikipedia-uncited" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010887 ; owl:annotatedTarget _:genid151983 . [] oboInOwl:hasDbXref "Wikipedia:Tragus_(ear)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010887 ; owl:annotatedTarget "A small pointed eminence of the external ear, situated in front of the concha, and projecting backward over the meatus." . [] oboInOwl:source "ncithesaurus:Tragus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010887 ; owl:annotatedTarget "UMLS:C0229312" . [] oboInOwl:hasDbXref "FMA:60998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010887 ; owl:annotatedTarget "tragal part of pinna" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget _:genid151992 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "Muscles of the pelvic girdle, hindlimb or pelvic fin." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000218" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "Muscles of the pelvic girdle, thigh, leg (crus), and foot (pes).[AAO]" . [] oboInOwl:hasDbXref "AAO:0000218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "pelvic girdle and hind limb muscles" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "pelvic girdle or hind limb muscle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "pelvic girdle or posterior limb muscle" . [] oboInOwl:hasDbXref "FMA:9622" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "lower limb muscle" . [] oboInOwl:hasDbXref "FMA:9622" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010890 ; owl:annotatedTarget "muscle of lower limb" . _:genid149982 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010708 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004571 . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget _:genid152005 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "A muscle of a pectoral girdle, pectoral fin or anterior limb." . _:genid149988 oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010687" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "Muscles of the pectoral girdle, arm, forearm, and hand (brachium, antebrachium, manus respectively).[AAO]" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001516 . [] oboInOwl:hasDbXref "AAO:0010687" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "pectoral girdle and fore limb muscles" . [] oboInOwl:hasDbXref "NCBITaxon:8782" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "muscle of pectoral girdle and wing" . [] oboInOwl:hasDbXref "FMA:9621" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "muscle of upper limb" . [] oboInOwl:hasDbXref "FMA:9621" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010891 ; owl:annotatedTarget "upper limb muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010893 ; owl:annotatedTarget "Am unpaired external naris that lies in the midline of the head." . [] oboInOwl:hasDbXref "http://tolweb.org/Hyperoartia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010893 ; owl:annotatedTarget "nasohypophysial opening" . [] a owl:Axiom ; rdfs:comment "We need to import uberon muscle to create a stricter domain constraint" ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0002372 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:13753780" . [] oboInOwl:hasDbXref "http://tolweb.org/Hyperoartia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010894 ; owl:annotatedTarget "horny denticle" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010899 ; owl:annotatedTarget obo:UBERON_0007197 . [] oboInOwl:hasDbXref "CARO:0000046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010899 ; owl:annotatedTarget "Hermaphroditic organism that produces both male and female gametes at the same time." . [] oboInOwl:hasDbXref "CARO:0000046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010899 ; owl:annotatedTarget "serially hermaphroditic organism" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010899 ; owl:annotatedTarget "simultaneous hermaphroditic organism" . _:genid150014 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001048 [ a owl:Restriction ; owl:onProperty obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0001105 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000178 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010905 ; owl:annotatedTarget _:genid152038 . _:genid150019 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010905 ; owl:annotatedTarget _:genid152040 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 . [] oboInOwl:editor "mah" ; oboInOwl:notes "shown in mouse" ; oboInOwl:source "PMC1352163" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010905 ; owl:annotatedTarget _:genid152042 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010905 ; owl:annotatedTarget "A primordium that develops into a clavicle bone." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010911 ; owl:annotatedTarget obo:UBERON_0004765 . [] oboInOwl:hasDbXref "PSPUB:0000169", "VSAO:0000132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010911 ; owl:annotatedTarget "Skeletal element that is often isolated, small, and variable in composition." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget obo:UBERON_0011216 . [] oboInOwl:source "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget _:genid152048 . _:genid150026 oboInOwl:source "VSAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget _:genid152050 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010212 . [] oboInOwl:hasDbXref "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." . _:genid150028 oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000042" ; oboInOwl:notes "incorrect" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:curator" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget "Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010221 . [] oboInOwl:hasDbXref "VSAO:0000042" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget "skeletal subdivision" . [] oboInOwl:hasDbXref "FMA:23879" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010912 ; owl:annotatedTarget "subdivision of skeleton (in vivo)" . _:genid150031 oboInOwl:source "VSAO", "https://github.com/obophenotype/uberon/issues/82" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget obo:UBERON_0004765 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010212 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget _:genid152057 . _:genid150033 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget _:genid152059 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010221 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "Skeletal element that forms around the notochord and is part of the vertebral column." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001143" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1016/j.cub.2011.07.014 Janvier P, Comparative anatomy: all vertebrates do have vertebrae. Current Biology (2011)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "In contrast to lampreys and jawed vertebrates, hagfishes were thought to lack vertebrae. Now, long overlooked vertebral rudiments have been analysed in hagfish, suggesting that vertebrae existed in the last common ancestor of all vertebrates.[well established][VHOG]" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "vertebra skeletal element" . _:genid150037 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "vertebra element" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010215 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/82" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "vertebra endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/82" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010913 ; owl:annotatedTarget "vertebral endochondral element" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010929 ; owl:annotatedTarget obo:UBERON_0005865 . _:genid150041 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010929 ; owl:annotatedTarget _:genid152068 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010929 ; owl:annotatedTarget _:genid152070 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget obo:UBERON_0006328 . _:genid150044 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget _:genid152073 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002539 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget _:genid152075 . _:genid150046 oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget _:genid152077 ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003115 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget _:genid152079 . _:genid150048 oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "Cricoarytenoid muscles are muscles that connect the cricoid cartilage and arytenoid cartilage. More specifically, it can refer to: Posterior cricoarytenoid muscle Lateral cricoarytenoid muscle." ; owl:onProperty obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0003117 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "EMAPA:37498" . [] oboInOwl:source "ncithesaurus:Cricoarytenoid_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "UMLS:C0448336" . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "crico-arytenoid" . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "cricoarytenoid" . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010932 ; owl:annotatedTarget "cricoarytenoid muscle" . [] oboInOwl:notes "cranial nerve VII buccal branch of the facial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget _:genid152099 . [] oboInOwl:notes "Maxilla and mandible" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget _:genid152101 . [] oboInOwl:notes "Maxilla and mandible" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget _:genid152103 . _:genid150069 oboInOwl:notes "Skin around the lips" ; oboInOwl:source "dbpedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget _:genid152105 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001894 . [] oboInOwl:hasDbXref "DOI:10.1002/ar.21355", "DOI:10.1111/j.1469-7580.2009.01111.x", "FEED:rd", "MFMO:0000058", "http://www.feedexp.org/wiki/Mammalian_Muscle_Ontology_Workshop" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "The orbicularis oris is a superficial facial muscle with fibers that encircle the opening of the oral cavity that attaches to the maxilla, mandible, skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve (CN VII)." . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "The orbicularis oris is a superficial facial muscle that attaches to the skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve .[FEED]" . _:genid150072 oboInOwl:hasDbXref "FMA:46841" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "orbicularis oris" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004141 . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "incisivii labii inferioris" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "incisivii labii superioris" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oris_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "musculus orbicularis oris" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "nasolabialis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Orbicularis_oris_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010933 ; owl:annotatedTarget "orbicularis oris" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010935 ; owl:annotatedTarget obo:UBERON_0005865 . _:genid150079 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010935 ; owl:annotatedTarget _:genid152116 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000019 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010935 ; owl:annotatedTarget _:genid152118 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010938 ; owl:annotatedTarget _:genid152120 . [] oboInOwl:hasDbXref "FMA:9719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010938 ; owl:annotatedTarget "belly" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0010938 ; owl:annotatedTarget "venter" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "Either of the two muscles that comprise the digastric group (anterior or posterior)." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "FMA represents this as a muscle belly, but this classification does not work well across mammals (pers. comm., FEED:rd), so we classify this is a distinct muscle organ here." . [] oboInOwl:hasDbXref "FMA:46297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "belly of digastric" . [] oboInOwl:hasDbXref "FMA:46297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "digastric belly" . [] oboInOwl:hasDbXref "FMA:46297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "belly of digastric muscle" . [] oboInOwl:hasDbXref "FMA:46291" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "digastric" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "digastric muscle" . [] oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "digastricus" . [] oboInOwl:hasDbXref "FMA:46297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "muscle body proper of digastric" . _:genid150097 oboInOwl:hasDbXref "Wikipedia:Digastric_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010940 ; owl:annotatedTarget "musculus digastricus" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:14663195" . ( ) . ( ) . _:genid150107 a owl:Restriction ; owl:onProperty obo:RO_0002005, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001684, obo:UBERON_0002019 . [] oboInOwl:notes "mandibular division (V3) of the trigeminal (CN V) via the mylohyoid nerve" ; oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget _:genid152146 . _:genid150109 oboInOwl:hasDbXref "MFMO:0000073", "http://www.feedexp.org/" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid (a branch of the third division of the trigeminal nerve), is attached to the mandible and to the hyoid apparatus, and it is superficial to mylohyoid muscle." ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0003216 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid and superficial to mylohyoid muscle, and lacks the midline raphe.[FEED]" . _:genid150111 oboInOwl:source "DOI:10.1007/BF02547558" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "absent in orangutans" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001738 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "EMAPA:37405" . [] oboInOwl:hasDbXref "FMA:46302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "anterior belly of digastric" . [] oboInOwl:hasDbXref "FEED:FEED" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "digastric, anterior" . [] oboInOwl:hasDbXref "FMA:46302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "venter anterior (musculus digastricus)" . [] oboInOwl:hasDbXref "FMA:46302", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010943 ; owl:annotatedTarget "venter posterior musculus digastrici anterior" . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget _:genid152159 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget _:genid152161 . [] oboInOwl:hasDbXref "Wikipedia:Occipitofrontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "The occipitofrontalis or epicranius is a muscle which covers parts of the skull. It consists of two parts or bellies: The occipital belly, near the occipital bone, and the frontal belly, near the frontal bone." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "A zone of muscle in FMA" . [] oboInOwl:source "ncithesaurus:Occipito-frontalis_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "UMLS:C1518531" . [] oboInOwl:hasDbXref "Wikipedia:Occipitofrontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "epicranius" . _:genid150124 oboInOwl:hasDbXref "Wikipedia:Occipitofrontalis_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "musculus occipitofrontalis" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0000929 . [] oboInOwl:hasDbXref "Wikipedia:Occipitofrontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010946 ; owl:annotatedTarget "occipitofrontalis" . _:genid150126 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001105 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0001676 ] ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0003216 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002049 ; owl:annotatedTarget obo:CL_0002400 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010948 ; owl:annotatedTarget "A muscle organ that attaches_to a clavicle and attaches_to a occipital bone." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010948 ; owl:annotatedTarget "EMAPA:37688" . [] oboInOwl:hasDbXref "MA:0002276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010948 ; owl:annotatedTarget "cleidooccipital" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002049 ; owl:annotatedTarget "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010949 ; owl:annotatedTarget "A muscle organ that has_muscle_insertion a occipital bone and has_muscle_origin a sternum." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010949 ; owl:annotatedTarget "EMAPA:37702" . [] oboInOwl:source "ncithesaurus:Sternooccipital" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010949 ; owl:annotatedTarget "UMLS:C1710196" . [] oboInOwl:hasDbXref "MA:0002385" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010949 ; owl:annotatedTarget "sternooccipital" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget _:genid152188 . [] oboInOwl:hasDbXref "Wikipedia:Occipitofrontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "A belly of the occipitofrontalis muscle that is near the frontal bone." . [] oboInOwl:hasDbXref "FMA:46757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "frontal belly of occipitofrontalis" . [] oboInOwl:hasDbXref "FMA:46757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "frontal part of occipitofrontalis" . _:genid150149 oboInOwl:hasDbXref "FMA:46757" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "frontalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009584 . [] oboInOwl:hasDbXref "Wikipedia:Frontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "frontalis muscke" . _:genid150151 oboInOwl:hasDbXref "PMID:18657257" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "orbito-temporo-auricularis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010258 . [] oboInOwl:hasDbXref "FMA:46757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "venter frontalis (musculus occipitofrontalis)" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "venter frontalis musculus occipitofrontalis" . [] oboInOwl:hasDbXref "Wikipedia:Frontalis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "frontal belly of occipitofrontalis muscle" . [] oboInOwl:hasDbXref "Wikipedia:Frontalis_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010952 ; owl:annotatedTarget "venter frontalis musculi occipitofrontalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget obo:UBERON_0008522 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget _:genid152201 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget _:genid152203 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget _:genid152205 . [] oboInOwl:hasDbXref "Wikipedia:Nasalis_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "The nasalis (compressor naris) is a sphincter-like muscle of the nose whose function is to compress the nasal cartilage. It consists of two parts, transverse and alar: The transverse part arises from the maxilla, above and lateral to the incisive fossa; its fibers proceed upward and medially, expanding into a thin aponeurosis which is continuous on the bridge of the nose with that of the muscle of the opposite side, and with the aponeurosis of the Procerus. The alar part is attached at one end to the greater alar cartilage, and at the other to the integument at the point of the nose. Other sources divide it into 'Compressor nasalis' and 'Dilator nasalis'." . [] oboInOwl:hasDbXref "FMA:46770" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "nasalis" . _:genid150162 oboInOwl:hasDbXref "Wikipedia:Nasalis_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "compressor naris" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010045 . [] oboInOwl:hasDbXref "Wikipedia:Nasalis_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "compressor narium minor" . _:genid150164 oboInOwl:hasDbXref "Wikipedia:Nasalis_muscle" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "compressor nasi" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010258 . [] oboInOwl:hasDbXref "Wikipedia:Nasalis_muscle" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010953 ; owl:annotatedTarget "musculus nasalis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010955 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010955 ; owl:annotatedTarget _:genid152214 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010955 ; owl:annotatedTarget _:genid152216 . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010959 ; owl:annotatedTarget _:genid152222 . _:genid150174 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010959 ; owl:annotatedTarget "Any muscle organ that is part of either the head or the neck." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005689 . [] oboInOwl:source "ncithesaurus:Head_and_Neck_Muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010959 ; owl:annotatedTarget "UMLS:C0448281" . _:genid150176 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010962 ; owl:annotatedTarget obo:UBERON_0005865 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010258 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010962 ; owl:annotatedTarget _:genid152227 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010963 ; owl:annotatedTarget _:genid152229 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010970 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010970 ; owl:annotatedTarget _:genid152232 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010970 ; owl:annotatedTarget _:genid152234 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010970 ; owl:annotatedTarget _:genid152236 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010975 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010975 ; owl:annotatedTarget _:genid152239 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010975 ; owl:annotatedTarget _:genid152241 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010977 ; owl:annotatedTarget obo:UBERON_0005865 . _:genid150187 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010977 ; owl:annotatedTarget _:genid152244 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005690 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010982 ; owl:annotatedTarget obo:UBERON_0005865 . _:genid150189 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010982 ; owl:annotatedTarget _:genid152247 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003852 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010982 ; owl:annotatedTarget _:genid152249 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010983 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010983 ; owl:annotatedTarget _:genid152252 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010983 ; owl:annotatedTarget _:genid152254 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010984 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010984 ; owl:annotatedTarget _:genid152257 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010984 ; owl:annotatedTarget _:genid152259 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010986 ; owl:annotatedTarget obo:UBERON_0005865 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010986 ; owl:annotatedTarget _:genid152262 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010986 ; owl:annotatedTarget _:genid152264 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:15092448" . [] oboInOwl:hasDbXref "EHDAA2:0001833" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010986 ; owl:annotatedTarget "serratus anterior pre-muscle mass" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget obo:UBERON_0001994 . _:genid150202 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget _:genid152268 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005691 . [] oboInOwl:hasDbXref "BTO:0001572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." . _:genid150204 oboInOwl:source "ncithesaurus:Articular_Cartilage" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "UMLS:C0007303" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010258 . [] oboInOwl:hasDbXref "MA:0000487" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "articular cartilage" . _:genid150206 oboInOwl:hasDbXref "FMA:12264" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "cartilago articularis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003852 . [] oboInOwl:hasDbXref "BTO:0001572" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "hyaline cartilage" . [] oboInOwl:hasDbXref "AEO:0000179" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0010996 ; owl:annotatedTarget "joint-associated cartilage" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011004 ; owl:annotatedTarget obo:UBERON_0003933 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011004 ; owl:annotatedTarget _:genid152281 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011004 ; owl:annotatedTarget "A cartilage element that is part of a splanchnocranium." . [] oboInOwl:hasDbXref "ZFA:0001460" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011004 ; owl:annotatedTarget "pharyngeal arch cartilages" . [] oboInOwl:hasDbXref "ZFA:0001460" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011004 ; owl:annotatedTarget "splanchnocranium cartilage" . _:genid150219 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000311 _:genid150221 _:genid150223 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010031 . _:genid150221 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002386, obo:UBERON_0010258 . _:genid150223 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0003852, obo:UBERON_0005897 . [] oboInOwl:hasDbXref "Wikipedia:Extrinsic_extensor_muscles_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011024 ; owl:annotatedTarget "The extrinsic extensor muscles of the hand are located in the back of the forearm and have long tendons connecting them to bones in the hand, where they exert their action." . [] oboInOwl:hasDbXref "Wikipedia:Extrinsic_extensor_muscles_of_the_hand" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011024 ; owl:annotatedTarget "extrinsic extensor muscle of hand" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget obo:UBERON_0010912 . _:genid150230 oboInOwl:source "VHOG" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget _:genid152297 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007213 . [] oboInOwl:hasDbXref "VHOG:0000511", "https://github.com/obophenotype/uberon/issues/153" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000511" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "dorsal visceral arch 1" . [] oboInOwl:hasDbXref "ZFA:0001272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "upper pharyngeal jaw" . [] oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "dorsal mandibular arch" . [] oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "dorsal pharyngeal arch 1" . [] oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "dorsal visceral arch 1" . [] oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "palatoquadrate arch" . _:genid150239 oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "upper jaw" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003852 . [] oboInOwl:hasDbXref "VHOG:0000511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011085 ; owl:annotatedTarget "upper pharyngeal jaw" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011088 ; owl:annotatedTarget "A ligament that is part of a knee joint." . [] oboInOwl:hasDbXref "FMA:44580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011088 ; owl:annotatedTarget "knee joint ligament" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011090 ; owl:annotatedTarget "A skeleton of pelvic girdle that is part of a right pelvic girdle region." . _:genid150254 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005884, obo:UBERON_0011093 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011091 ; owl:annotatedTarget "A skeleton of pelvic girdle that is part of a left pelvic girdle region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011092 ; owl:annotatedTarget "A pelvic girdle region that is in the right side of a multicellular organism." . [] oboInOwl:hasDbXref "FMA:16582" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011092 ; owl:annotatedTarget "right pelvic girdle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011093 ; owl:annotatedTarget "A pelvic girdle region that is in the left side of a multicellular organism." . [] oboInOwl:hasDbXref "FMA:16583" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011093 ; owl:annotatedTarget "left pelvic girdle" . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011094 ; owl:annotatedTarget "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." . [] oboInOwl:notes "vertebra-like cartilage in hagfish are homologous to gnathostome vertebrae. mesenchymal cells express Pax1/9 and Twist" ; oboInOwl:source "PMC3157150" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0011094 ; owl:annotatedTarget obo:NCBITaxon_7764 . [] oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011094 ; owl:annotatedTarget "This class is a superclass of individual vertebral cartilage condensations. Note that EHDAA2 represents these as condensation groups" . [] oboInOwl:hasDbXref "VHOG:0000584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011094 ; owl:annotatedTarget "vertebral cartilage condensation" . _:genid150283 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866, obo:UBERON_0009581 . _:genid150285 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002412, obo:UBERON_0010286 . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011095 ; owl:annotatedTarget _:genid152354 . [] oboInOwl:hasDbXref "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011095 ; owl:annotatedTarget "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." . [] oboInOwl:hasDbXref "VHOG:0000582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011095 ; owl:annotatedTarget "vertebral pre-cartilage condensation" . _:genid150291 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001817, obo:UBERON_0003080 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011096 ; owl:annotatedTarget _:genid152363 . _:genid150294 oboInOwl:hasDbXref "Wikipedia:Lacrimal_nerve" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011096 ; owl:annotatedTarget "The lacrimal nerve is the smallest of the three branches of the ophthalmic division of the trigeminal nerve." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001773 . [] oboInOwl:hasDbXref "Wikipedia:Lacrimal_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011096 ; owl:annotatedTarget "nervus lacrimalis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:15094021" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002050 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011104 ; owl:annotatedTarget "An epiphysis that is part of a metacarpal bone of digit 5." . [] oboInOwl:hasDbXref "FMA:86330" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011104 ; owl:annotatedTarget "fifth metacarpal bone epiphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011107 ; owl:annotatedTarget "A synovial joint that is part of a pelvic girdle region." . [] oboInOwl:source "ncithesaurus:Joint_of_the_Pelvic_Girdle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011107 ; owl:annotatedTarget "UMLS:C0827002" . [] oboInOwl:hasDbXref "FMA:35173" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011107 ; owl:annotatedTarget "pelvic girdle joint" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002050 ; owl:annotatedTarget "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011108 ; owl:annotatedTarget "A synovial joint that is part of a pectoral girdle region." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011108 ; owl:annotatedTarget "in FMA, these are part of the bony pectoral girdle" . [] oboInOwl:hasDbXref "FMA:35243" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011108 ; owl:annotatedTarget "pectoral girdle joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011110 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011110 ; owl:annotatedTarget _:genid152396 . [] oboInOwl:hasDbXref "Wikipedia:Humeroulnar_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011110 ; owl:annotatedTarget "The humeroulnar joint, is part of the elbow-joint or the Olecron Joint, between the ulna and humerus bones is the simple hinge-joint, which allows for movements of flexion, extension and circumduction. The Humero-Ulnar Joint is the junction of trochlear notch of the ulna and the trochlea of the humerus. Owing to the obliquity of the trochlea of the humerus, this movement does not take place in the antero-posterior plane of the body of the humerus. When the forearm is extended and supinated, the axis of the arm and forearm are not in the same line; the arm forms an obtuse angle with the forearm. During flexion, however, the forearm and the hand tend to approach the middle line of the body, and thus enable the hand to be easily carried to the face. The accurate adaptation of the trochlea of the humerus, with its prominences and depressions, to the semilunar notch of the ulna, prevents any lateral movement. Flexion is produced by the action of the Biceps brachii and Brachialis, assisted by the Brachioradialis, with a tiny contribution from the muscles arising from the medial epicondyle of the humerus. Extension is produced by the Triceps brachii and AnconC&us, with a tiny contribution from the muscles arising from the lateral epicondyle of the humerus, such as the Extensor digitorum communis." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011110 ; owl:annotatedTarget "articulatio humeroulnaris" . [] oboInOwl:hasDbXref "FMA:38854" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011110 ; owl:annotatedTarget "humero-ulnar joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011111 ; owl:annotatedTarget _:genid152407 . [] oboInOwl:hasDbXref "Wikipedia:Humeroradial_joint", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011111 ; owl:annotatedTarget "A hinge joint between the head of the radius and the capitulum of the humerus." . [] oboInOwl:hasDbXref "Wikipedia:Humeroradial_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011111 ; owl:annotatedTarget "articulatio humeroradialis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011112 ; owl:annotatedTarget obo:UBERON_0002210 . [] oboInOwl:hasDbXref "Wikipedia:Tibiofibular_joint", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011112 ; owl:annotatedTarget "A joint that connects the tibia and the fibula." . _:genid150354 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002387, obo:UBERON_0003071 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "The tarsometatarsal articulations are arthrodial joints in the pes." . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "Lisfranc joint" . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "articulationes tarsometatarsales" . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "cuboideometatarsal" . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "tarsometatarsal" . [] oboInOwl:hasDbXref "Wikipedia:Tarsometatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011118 ; owl:annotatedTarget "tarsometatarsal articulation" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones." . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "CMJ" . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "carpometacarpal" . [] oboInOwl:source "ncithesaurus:Carpometacarpal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "UMLS:C0224620" . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "articulationes carpometacarpeæ" . _:genid150375 oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011119 ; owl:annotatedTarget "carpometacarpal articulation" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011120 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011120 ; owl:annotatedTarget "A skeletal joint that connects a laryngeal cartilage." . [] oboInOwl:hasDbXref "FMA:55100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011120 ; owl:annotatedTarget "joint of larynx" . [] oboInOwl:hasDbXref "FMA:55100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011120 ; owl:annotatedTarget "laryngeal articulation" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget obo:UBERON_0011120 . _:genid150392 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget _:genid152465 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010377 . [] oboInOwl:hasDbXref "Wikipedia:Cricothyroid_articulation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget "The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the thyroid cartilage." . [] oboInOwl:source "ncithesaurus:Cricothyroid_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget "UMLS:C0225540" . [] oboInOwl:hasDbXref "FMA:55101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget "cricothyroid articulation" . [] oboInOwl:hasDbXref "Wikipedia:Cricothyroid_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011121 ; owl:annotatedTarget "crico-thyroid joint" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:15554424" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget obo:UBERON_0011120 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget _:genid152478 . _:genid150405 oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_articulation" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget "The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the arytenoid cartilage." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003372 . [] oboInOwl:source "ncithesaurus:Cricoarytenoid_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget "UMLS:C0225555" . [] oboInOwl:hasDbXref "FMA:55102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget "crico-arytenoid joint" . [] oboInOwl:hasDbXref "FMA:55102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget "cricoarytenoid articulation" . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011122 ; owl:annotatedTarget "crico-arytenoid joint" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011130 ; owl:annotatedTarget _:genid152485 . [] oboInOwl:hasDbXref "EMAPA:18714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011130 ; owl:annotatedTarget "temporo-mandibular joint primordium" . (obo:UBERON_0000982 [ a owl:Restriction ; owl:onClass obo:UBERON_0002374 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011131 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:notes "two adjacent metacarpals" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011131 ; owl:annotatedTarget _:genid152494 . [] oboInOwl:hasDbXref "FMA:35288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011131 ; owl:annotatedTarget "A skeletal joint that connects two adjacent metacarpals[FMA,modified]." . [] oboInOwl:hasDbXref "Wikipedia:Intermetacarpal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011131 ; owl:annotatedTarget "intermetacarpal" . [] oboInOwl:hasDbXref "Wikipedia:Intermetacarpal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011131 ; owl:annotatedTarget "intermetacarpal articulation" . (obo:UBERON_0000982 [ a owl:Restriction ; owl:onClass obo:UBERON_0001435 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget _:genid152504 . [] oboInOwl:notes "two adjacent carpals" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget _:genid152506 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "A skeletal joint that connects two carpal bones." . [] oboInOwl:source "ncithesaurus:Carpal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "UMLS:C1262468" . [] oboInOwl:hasDbXref "FMA:35292" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "carpal joint" . [] oboInOwl:hasDbXref "Wikipedia:Intercarpal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "intercarpal" . [] oboInOwl:hasDbXref "Wikipedia:Intercarpal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "intercarpal articulation" . [] oboInOwl:hasDbXref "Wikipedia:Intercarpal_articulations" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011132 ; owl:annotatedTarget "midcarpal articulation" . _:genid150435 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000982 _:genid150437 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009526 . _:genid150437 a owl:Restriction ; owl:onClass obo:UBERON_0001448 ; owl:onProperty obo:RO_0002176, obo:RO_0002202 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:someValuesFrom obo:UBERON_0010338 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011133 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:notes "two adjacent metatarsals" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011133 ; owl:annotatedTarget _:genid152520 . [] oboInOwl:hasDbXref "Wikipedia:Intermetatarsal_articulations" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011133 ; owl:annotatedTarget "A joint that connects two adjacent metatarsals." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011133 ; owl:annotatedTarget "In humans: The base of the first metatarsal is not connected with that of the second by any ligaments; in this respect the great toe resembles the thumb" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011134 ; owl:annotatedTarget obo:UBERON_0000982 . [] oboInOwl:hasDbXref "FMA:7491" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011134 ; owl:annotatedTarget "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." . [] oboInOwl:hasDbXref "FMA:7491" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011134 ; owl:annotatedTarget "solid joint" . _:genid150447 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0007844 _:genid150449 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006905 . _:genid150449 a owl:Restriction ; owl:onClass obo:UBERON_0001075 ; owl:onProperty obo:RO_0002202, obo:RO_0002220 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:someValuesFrom obo:UBERON_0010252 . [] oboInOwl:source "FMA", "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011135 ; owl:annotatedTarget _:genid152531 . [] oboInOwl:notes "between two centra" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011135 ; owl:annotatedTarget _:genid152533 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011135 ; owl:annotatedTarget "A cartilage element that lies between two successive vertebral centra." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000795" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:Trueb_1973" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011135 ; owl:annotatedTarget "Block of cartilage, which usually ossifies, that lies between successive vertebral centra.[AAO]" . _:genid150459 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130, obo:UBERON_0006905 . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011136 ; owl:annotatedTarget "Ligament that joins successive centra. Important in controlling the stiffness of the vertebral column when it flexes." . _:genid150461 oboInOwl:hasDbXref "FMA:31892" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011136 ; owl:annotatedTarget "vertebral column ligament" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010339 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011137 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011137 ; owl:annotatedTarget "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011138 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011138 ; owl:annotatedTarget _:genid152549 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/44", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011138 ; owl:annotatedTarget "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011138 ; owl:annotatedTarget "axial skeletal system" . (obo:UBERON_0002217 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002101 ] ) . ( ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011139 ; owl:annotatedTarget "Any synovial joint that is part of a (free) limb." . [] oboInOwl:hasDbXref "FMA:258776" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011139 ; owl:annotatedTarget "synovial joint of free limb segment" . [] oboInOwl:hasDbXref "PSPUB:0000169", "VSAO:0000131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011141 ; owl:annotatedTarget "Ossicle that is part of the appendicular skeleton." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011141 ; owl:annotatedTarget "ossicle of appendicular skeleton" . (obo:UBERON_0010911 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002090 ] ) . ( ) . [] oboInOwl:hasDbXref "PSPUB:0000169", "VSAO:0000133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011142 ; owl:annotatedTarget "Ossicle that is part of the axial skeleton." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011142 ; owl:annotatedTarget "ossicle of axial skeleton" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011142 ; owl:annotatedTarget "ossicle of postcranial-axial skeleton" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011142 ; owl:annotatedTarget "vertebral ossicle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011143 ; owl:annotatedTarget _:genid152573 . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011143 ; owl:annotatedTarget _:genid152577 . [] oboInOwl:hasDbXref "FMA:45658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011143 ; owl:annotatedTarget "Subdivision of urinary system which consists of the kidney and the ureters." . _:genid150495 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0011145 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010042 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:15969015" . [] oboInOwl:notes "a small part of adductor magnus is innervated by the tibial nerve" ; oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011144 ; owl:annotatedTarget _:genid152584 . [] oboInOwl:hasDbXref "Wikipedia:Adductor_muscles_of_the_hip" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011144 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "MA:0002267" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011144 ; owl:annotatedTarget "adductor group (leg)" . [] oboInOwl:hasDbXref "Wikipedia:Adduction", "Wikipedia:Adductor_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011145 ; owl:annotatedTarget "A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002136" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFA:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011145 ; owl:annotatedTarget "A muscle that brings a body part closer to the sagittal plane of the body.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0002136" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011145 ; owl:annotatedTarget "relationship loss: subclass cranial muscle (TAO:0001953)[TAO]" . _:genid150506 oboInOwl:external_ontology "TAO" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011145 ; owl:annotatedTarget "we place the TAO class here even though it is a cranial muscle; it is defined functionally" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005689 . (obo:UBERON_0000414 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0000009 ] ) . [] oboInOwl:notes "perforates" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011148 ; owl:annotatedTarget _:genid152597 . [] oboInOwl:hasDbXref "BTO:0003751", "Wikipedia:Submucosal_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011148 ; owl:annotatedTarget "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011148 ; owl:annotatedTarget "EMAPA:37970" . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436", "https://github.com/obophenotype/uberon/issues/232" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "A muscle whose action is to depress the lower jaw." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000612" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "Muscle located on ventral side of the head, linking the ventral hyoid arch to the dentary. Innervated by ramus mandibularis V and ramus hyoides VII.[TAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010655" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:BMZ" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "Muscle that pulls the hyoid apparatus forward and depresses the lower jaw.[AAO]" . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010655" ; oboInOwl:ontology "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000612" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "Source: Winterbottom, R. 1973. A Descriptive Synonymy of the Striated Muscles of the Teleostei. Proceedings of the Academy of Natural Sciences of Philadelphia, Vol. 125 (1973), pp. 225-317.[TAO]" . _:genid150519 oboInOwl:source "DOI:10.1006/bijl.2000.0436" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "In amphibians, 'Muscle that pulls the hyoid apparatus forward and depresses the lower jaw.' [AAO:0010655]. 'The protractor hyoideus muscle in teleosts is commonly, albeit mistakenly, referred to as the geniohyoideus muscle, which is involved in the coracomandibularis coupling. According to Edgeworth (1935) and Winterbottom (1974), the protractor hyoideus is composed of a fusion of the intermandibularis posterior and the interhyoideus muscles which resulted in the protractor hyoideus which spans the hyoid and mandible. The intermandibularis spans the mandible while the closely apposed interhyoideus spans the hyoid in other fishes. Furthermore, they concluded that any muscle that is homologous to the geniohyoideus (coracomandibularis coupling) in other lower vertebrates has been lost in teleosts, as well as gars. However, the protractor hyoideus muscle is functionally analogous to the coracomandibularis coupling of other vertebrates and so we use it in our discussion to show the phylogenetically broad roles of these couplings in jaw mechanics.'" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005690 . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "branchiomandibularis" . _:genid150521 oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "coracomandibularis" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "depressor gnathalis" . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436", "TAO:0000612" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "geniohyoideus" . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "geniohyoideus muscle" . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "geniothoracis" . [] oboInOwl:hasDbXref "TAO:0000612" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "protractor hyoidei" . [] oboInOwl:hasDbXref "DOI:10.1006/bijl.2000.0436" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011151 ; owl:annotatedTarget "protractor hyoideus" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011152 ; owl:annotatedTarget _:genid152615 . [] oboInOwl:hasDbXref "ZFA:0001401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011152 ; owl:annotatedTarget "dorsal hyoid arch" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002052 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "ZFA:0001401" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011152 ; owl:annotatedTarget "dorsal visceral arch 2" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget obo:UBERON_0011158 . _:genid150532 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget _:genid152620 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005691 . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget _:genid152622 . _:genid150534 oboInOwl:hasDbXref "MP:0005274", "Wikipedia:Facial_skeleton", "http://www.bartleby.com/107/37.html", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "Subdivision of skull that consists of the facial bones." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 . [] oboInOwl:hasDbXref "FMA:53673" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "facial skeleton" . [] oboInOwl:hasDbXref "MA:0000318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "facial bone" . [] oboInOwl:hasDbXref "Wikipedia:Facial_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "ossa facialia" . [] oboInOwl:hasDbXref "Wikipedia:Facial_skeleton" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "ossa faciei" . [] oboInOwl:hasDbXref "MA:0000318" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011156 ; owl:annotatedTarget "viscerocranium" . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002052 ; owl:annotatedTarget "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011158 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011158 ; owl:annotatedTarget "The skull can be divided into two: the neurocranium and the facial skeleton." . [] oboInOwl:hasDbXref "FMA:54964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011158 ; owl:annotatedTarget "skull subdivision" . [] oboInOwl:hasDbXref "FMA:54964" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011158 ; owl:annotatedTarget "subdivision of skull" . _:genid150545 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010031, obo:UBERON_0010323 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011159 ; owl:annotatedTarget obo:UBERON_0000075 . _:genid150547 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0009199 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001681 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002052 ; owl:annotatedTarget "fraction D pre-B cell" . _:genid150551 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011160 ; owl:annotatedTarget "A suture joining a nasal bone to another bone." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010343 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011164 ; owl:annotatedTarget "A bone that is part of a neurocranium [Automatically generated definition]." . [] oboInOwl:hasDbXref "MA:0001478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011164 ; owl:annotatedTarget "chondrocranium bone" . (obo:UBERON_0000982 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003277 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0003278 ] ) . [] oboInOwl:source "abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011171 ; owl:annotatedTarget obo:UBERON_0002217 . [] oboInOwl:hasDbXref "http://evolution.berkeley.edu/evolibrary/article/evograms_05", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011171 ; owl:annotatedTarget "Synovial joint that articulates bones of upper and lower jaw." . [] oboInOwl:source "http://evolution.berkeley.edu" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011171 ; owl:annotatedTarget "Some synapsids retained two pairs of jaw joints - quadrate-articular and tempero-mandibular, but this unusual paired condition did not last long" . (obo:UBERON_0004590 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005409 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011185 ; owl:annotatedTarget "A sphincter muscle that is part of the gastrointestinal system." . [] oboInOwl:source "ncithesaurus:Gastrointestinal_Sphincter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011185 ; owl:annotatedTarget "UMLS:C1517464" . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget _:genid152667 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget _:genid152669 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget "A lamina propria that is part of a large intestine." . [] oboInOwl:source "ncithesaurus:Large_Intestinal_Lamina_Propria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget "UMLS:C1708644" . [] oboInOwl:hasDbXref "FMA:15654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget "lamina propria of mucosa of large intestine" . [] oboInOwl:hasDbXref "FMA:15654" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011189 ; owl:annotatedTarget "large intestine lamina propria" . [] oboInOwl:source "EHDAA2-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011191 ; owl:annotatedTarget obo:UBERON_0009141 . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011191 ; owl:annotatedTarget "Ophthalmic veins are veins which drain the eye. More specifically, they can refer to: Superior ophthalmic vein Inferior ophthalmic vein." . [] oboInOwl:hasDbXref "EHDAA2:0004113" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011191 ; owl:annotatedTarget "opthalmic vein" . [] oboInOwl:hasDbXref "Wikipedia:Ophthalmic_veins" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011191 ; owl:annotatedTarget "vena ophthalmica" . [] oboInOwl:hasDbXref "Wikipedia:Superior_ophthalmic_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011192 ; owl:annotatedTarget "The superior ophthalmic vein begins at the inner angle of the orbit in a vein named the nasofrontal which communicates anteriorly with the angular vein; it pursues the same course as the ophthalmic artery, and receives tributaries corresponding to the branches of that vessel. Forming a short single trunk, it passes between the two heads of the Rectus lateralis and through the medial part of the superior orbital fissure, and ends in the cavernous sinus. The ethmoidal veins drain into the superior ophthalmic vein. Vorticose veins also drain into the superior ophthalmic vein." . [] oboInOwl:hasDbXref "Wikipedia:Superior_ophthalmic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011192 ; owl:annotatedTarget "anterior ethmoidal vein" . [] oboInOwl:hasDbXref "Wikipedia:Superior_ophthalmic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011192 ; owl:annotatedTarget "posterior ethmoidal vein" . [] oboInOwl:hasDbXref "Wikipedia:Superior_ophthalmic_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011192 ; owl:annotatedTarget "superior ophthalmic" . [] oboInOwl:source "EHDAA2-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011197 ; owl:annotatedTarget obo:UBERON_0000486 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011197 ; owl:annotatedTarget "An epithelium that is part of a parathyroid gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16008360" . [] oboInOwl:source "ncithesaurus:Parathyroid_Gland_Epithelial_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011197 ; owl:annotatedTarget "UMLS:C1709466" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget _:genid152697 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "A muscle layer that is part of a large intestine." . [] oboInOwl:source "ncithesaurus:Large_Intestinal_Muscular_Coat" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "UMLS:C0734205" . [] oboInOwl:hasDbXref "FMA:14971" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "muscular coat of large intestine" . [] oboInOwl:hasDbXref "FMA:14971" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "muscular layer of large intestine" . [] oboInOwl:hasDbXref "FMA:14971" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "muscularis externa of large intestine" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011198 ; owl:annotatedTarget "tunica muscularis intestini crassi" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011200 ; owl:annotatedTarget obo:UBERON_0001468 . [] oboInOwl:hasDbXref "Wikipedia:Sacrococcygeal_symphysis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011200 ; owl:annotatedTarget "The sacrococcygeal symphysis (sacrococcygeal articulation, articulation of the sacrum and coccyx) is an amphiarthrodial joint, formed between the oval surface at the apex of the sacrum, and the base of the coccyx. It is a slightly moveable joint which is frequently, partially or completely, obliterated in old age, homologous with the joints between the bodies of the vertebrae." . [] oboInOwl:source "ncithesaurus:Sacrococcygeal_Joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011200 ; owl:annotatedTarget "UMLS:C0224593" . [] oboInOwl:hasDbXref "FMA:16210" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011200 ; owl:annotatedTarget "sacrococcygeal joint" . [] oboInOwl:hasDbXref "Wikipedia:Sacrococcygeal_symphysis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011200 ; owl:annotatedTarget "sacrococcygeal joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget _:genid152720 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "A muscle layer that is part of a small intestine." . [] oboInOwl:source "ncithesaurus:Small_Intestinal_Muscular_Coat" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "UMLS:C0227269" . [] oboInOwl:hasDbXref "FMA:14932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "muscular coat of small intestine" . [] oboInOwl:hasDbXref "FMA:14932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "muscular layer of small intestine" . [] oboInOwl:hasDbXref "FMA:14932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "muscularis externa of small intestine" . [] oboInOwl:hasDbXref "FMA:14932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "small intestine muscularis propria" . [] oboInOwl:hasDbXref "FMA:14932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "tunica muscularis (intestinum tenue)" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011201 ; owl:annotatedTarget "tunica muscularis intestini tenuis" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011202 ; owl:annotatedTarget obo:UBERON_0003914 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011202 ; owl:annotatedTarget "An epithelium that is part of a urachus." . [] oboInOwl:source "ncithesaurus:Urachal_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011202 ; owl:annotatedTarget "UMLS:C1711256" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011203 ; owl:annotatedTarget obo:UBERON_0007524 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011203 ; owl:annotatedTarget "Mesenchyme that is part of a developing urachus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011215 ; owl:annotatedTarget "A multi cell part structure that is part of a central nervous system." . [] oboInOwl:hasDbXref "FMA:83143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011215 ; owl:annotatedTarget "cell part cluster of neuraxis" . [] oboInOwl:hasDbXref "FMA:83143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011215 ; owl:annotatedTarget "neuraxis layer" . [] oboInOwl:source "FBbt" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011216 ; owl:annotatedTarget obo:UBERON_0010000 . _:genid150658 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011216 ; owl:annotatedTarget "A subdivision of an anatomical system." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003921 . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:source "ncithesaurus" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget _:genid152754 . [] oboInOwl:hasDbXref "Wikipedia:Mastoid_process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget "The mastoid process is a conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. It is located just behind the external acoustic meatus, and lateral to the styloid process. Its size and form vary somewhat; it is larger in the male than in the female. This process serves for the attachment of the posterior belly of the digastric, sternocleidomastoid, splenius capitis, and longissimus capitis muscles. The word is derived from the Greek 'masto-', alluding to its resemblance to the breast." . [] oboInOwl:source "ncithesaurus:Mastoid_Process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget "UMLS:C0446908" . [] oboInOwl:hasDbXref "FMA:52872" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget "mastoid process" . [] oboInOwl:hasDbXref "Wikipedia:Mastoid_process" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget "mastoid" . _:genid150665 oboInOwl:hasDbXref "Wikipedia:Mastoid_process" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011220 ; owl:annotatedTarget "processus mastoideus ossis temporalis" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003921 . [] oboInOwl:notes "organ component in FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011222 ; owl:annotatedTarget obo:UBERON_0001630 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011222 ; owl:annotatedTarget _:genid152763 . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0010038" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011222 ; owl:annotatedTarget "Muscles within the eye (bulbus oculi).[AAO]" . [] oboInOwl:hasDbXref "EMAPA:18808" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011222 ; owl:annotatedTarget "intrinsic ocular muscle" . _:genid150675 oboInOwl:hasDbXref "FMA:45087", "Wikipedia:Synovial_sheath" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011233 ; owl:annotatedTarget "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009142 . [] oboInOwl:hasDbXref "BTO:0001823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011233 ; owl:annotatedTarget "synovium" . _:genid150685 oboInOwl:hasDbXref "UBERONREF:0000007", "http://palaeos.com/vertebrates/bones/braincase/ethmoid.html" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011241 ; owl:annotatedTarget "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009142 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011249 ; owl:annotatedTarget "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000306" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011249 ; owl:annotatedTarget "Skeletal system which consists of the appendicular skeleton plus associated joints.[VSAO]" . _:genid150692 a owl:Restriction ; owl:onProperty obo:RO_0002005, obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0000013, obo:UBERON_0002481 . _:genid150694 a owl:Restriction ; owl:onProperty obo:RO_0002150, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001604, obo:UBERON_0015064 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011250 ; owl:annotatedTarget "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." . _:genid150696 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001604, obo:UBERON_0007827 . [] oboInOwl:hasDbXref "Wikipedia:Rhinarium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011256 ; owl:annotatedTarget "Moist, hairless, crenelated area around nostrils of some mammals." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16050680" . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint#Thumb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "A carpometacarpal joint that connects to metacarpal 1." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "In humans it connects the trapezium to the first metacarpal bone, plays an irreplaceable role in the normal functioning of the thumb. The most important joint connecting the wrist to the metacarpus, osteoarthritis of the TMC is a severely disabling condition; up to twenty times more common among old women than in average" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "carpometacarpal joint of digit I" . [] oboInOwl:hasDbXref "FMA:35421" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "carpometacarpal joint of pollex" . [] oboInOwl:hasDbXref "FMA:35421" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "carpometacarpal joint of thumb" . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint#Thumb" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "TMJ" . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint#Thumb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "carpometacarpal joint of the thumb" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002054 ; owl:annotatedTarget obo:CL_0000816 . [] oboInOwl:hasDbXref "Wikipedia:Carpometacarpal_joint#Thumb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011265 ; owl:annotatedTarget "trapeziometacarpal joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget obo:UBERON_0009569 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget _:genid152808 . [] oboInOwl:hasDbXref "UBERONREF:0000006", "Wikipedia:Human_back" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget "The part of the trunk that is in the dorsum[cjm]." . [] oboInOwl:hasDbXref "FMA:25056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget "back of trunk" . [] oboInOwl:hasDbXref "FMA:25056" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget "dorsum of trunk" . _:genid150716 oboInOwl:hasDbXref "FMA:25056" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011270 ; owl:annotatedTarget "trunk back" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001051 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011272 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011272 ; owl:annotatedTarget _:genid152815 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011272 ; owl:annotatedTarget _:genid152817 . [] oboInOwl:hasDbXref "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002054 ; owl:annotatedTarget "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." . [] oboInOwl:hasDbXref "Wikipathways:WP2062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011272 ; owl:annotatedTarget "outer epithelium of body" . _:genid150721 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001463 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002228 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget obo:UBERON_0009565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "A nail that is part of a manual digit 1." . [] oboInOwl:hasDbXref "EMAPA:18734" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "claw of digit 1 of fore-paw" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "nail of manual digit I" . [] oboInOwl:hasDbXref "FMA:54329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "nail of thumb" . [] oboInOwl:hasDbXref "FMA:54329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "nail plate of thumb" . [] oboInOwl:hasDbXref "FMA:54329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011273 ; owl:annotatedTarget "thumb nail" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget obo:UBERON_0009565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "A nail that is part of a manual digit 2." . [] oboInOwl:hasDbXref "EMAPA:18735" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "claw of digit 2 of fore-paw" . [] oboInOwl:hasDbXref "FMA:54332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "index finger nail" . [] oboInOwl:hasDbXref "FMA:54332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "nail of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "nail of manual digit II" . [] oboInOwl:hasDbXref "FMA:54332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "nail of second finger" . [] oboInOwl:hasDbXref "FMA:54332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011274 ; owl:annotatedTarget "nail plate of index finger" . _:genid150744 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001705 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003623 ] ) ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001194 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget obo:UBERON_0009565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "A nail that is part of a manual digit 3." . [] oboInOwl:hasDbXref "EMAPA:18736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "claw of digit 3 of fore-paw" . [] oboInOwl:hasDbXref "FMA:54335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "middle finger nail" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "nail of manual digit III" . [] oboInOwl:hasDbXref "FMA:54335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "nail of middle finger" . [] oboInOwl:hasDbXref "FMA:54335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "nail of third finger" . [] oboInOwl:hasDbXref "FMA:54335" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011275 ; owl:annotatedTarget "nail plate of middle finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget obo:UBERON_0009565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "A nail that is part of a manual digit 4." . [] oboInOwl:hasDbXref "EMAPA:18737" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "claw of digit 4 of fore-paw" . [] oboInOwl:hasDbXref "FMA:54338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "nail of fourth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "nail of manual digit IV" . [] oboInOwl:hasDbXref "FMA:54338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "nail of ring finger" . [] oboInOwl:hasDbXref "FMA:54338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "nail plate of ring finger" . [] oboInOwl:hasDbXref "FMA:54338" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011276 ; owl:annotatedTarget "ring finger nail" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget obo:UBERON_0009565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "A nail that is part of a manual digit 5." . [] oboInOwl:hasDbXref "EMAPA:18738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "claw of digit 5 of fore-paw" . [] oboInOwl:hasDbXref "FMA:54341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "little finger nail" . [] oboInOwl:hasDbXref "FMA:54341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "nail of fifth finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "nail of manual digit V" . [] oboInOwl:hasDbXref "FMA:54341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "nail plate of little finger" . [] oboInOwl:hasDbXref "FMA:54341" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011277 ; owl:annotatedTarget "nail of little finger" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget obo:UBERON_0009567 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "A nail that is part of a pedal digit 1." . [] oboInOwl:hasDbXref "FMA:54344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "big toe nail" . [] oboInOwl:hasDbXref "EMAPA:18739" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "claw of digit 1 of hind-paw" . [] oboInOwl:hasDbXref "FMA:54344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "nail of big toe" . [] oboInOwl:hasDbXref "FMA:54344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "nail of great toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "nail of pedal digit I" . [] oboInOwl:hasDbXref "FMA:54344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "nail plate of big toe" . [] oboInOwl:hasDbXref "FMA:54344" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011278 ; owl:annotatedTarget "nail of first toe" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget obo:UBERON_0009567 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "A nail that is part of a pedal digit 2." . _:genid150799 oboInOwl:hasDbXref "EMAPA:18740" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "claw of digit 2 of hind-paw" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010753 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16348008" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "nail of pedal digit II" . [] oboInOwl:hasDbXref "FMA:54347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "nail of second toe" . [] oboInOwl:hasDbXref "FMA:54347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "nail plate of second toe" . [] oboInOwl:hasDbXref "FMA:54347" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011279 ; owl:annotatedTarget "second toe nail" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget obo:UBERON_0009567 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "A nail that is part of a pedal digit 3." . [] oboInOwl:hasDbXref "EMAPA:18741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "claw of digit 3 of hind-paw" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "nail of pedal digit III" . [] oboInOwl:hasDbXref "FMA:54350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "nail of third toe" . _:genid150813 oboInOwl:hasDbXref "FMA:54350" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "nail plate of third toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004042 . [] oboInOwl:hasDbXref "FMA:54350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011280 ; owl:annotatedTarget "third toe nail" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget obo:UBERON_0009567 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "A nail that is part of a pedal digit 4." . [] oboInOwl:hasDbXref "EMAPA:18742" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "claw of digit 4 of hind-paw" . [] oboInOwl:hasDbXref "FMA:54353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "fourth toe nail" . [] oboInOwl:hasDbXref "FMA:54353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "nail of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "nail of pedal digit IV" . [] oboInOwl:hasDbXref "FMA:54353" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011281 ; owl:annotatedTarget "nail plate of fourth toe" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget obo:UBERON_0009567 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "A nail that is part of a pedal digit 5." . [] oboInOwl:hasDbXref "EMAPA:18743" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "claw of digit 5 of hind-paw" . [] oboInOwl:hasDbXref "FMA:54356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "little toe nail" . [] oboInOwl:hasDbXref "FMA:54356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "nail of fifth toe" . [] oboInOwl:hasDbXref "FMA:54356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "nail of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "nail of pedal digit V" . [] oboInOwl:hasDbXref "FMA:54356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011282 ; owl:annotatedTarget "nail plate of little toe" . _:genid150840 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001042, obo:UBERON_0002228 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011289 ; owl:annotatedTarget obo:UBERON_0006614 . [] oboInOwl:hasDbXref "Wikipedia:Pharyngobasilar_fascia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011289 ; owl:annotatedTarget "The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis." . [] oboInOwl:hasDbXref "FMA:55074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011289 ; owl:annotatedTarget "pharyngeal aponeurosis" . [] oboInOwl:hasDbXref "Wikipedia:Pharyngobasilar_fascia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011289 ; owl:annotatedTarget "pharyngeal aponeurosis" . [] oboInOwl:hasDbXref "BTO:0002116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011298 ; owl:annotatedTarget "The submucous layer of the wall of the uterine tube." . [] oboInOwl:hasDbXref "BTO:0002116" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011298 ; owl:annotatedTarget "tela submucosa tubae uterinae" . [] oboInOwl:hasDbXref "BTO:0002116" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011298 ; owl:annotatedTarget "submucous layer of uterine tube" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum." . [] oboInOwl:source "ZFA:0000597" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "CNS white matter that is part of the telencephalon[ZFA:0000597]." . [] oboInOwl:hasDbXref "BIRNLEX:1075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "predominantly white regional part of telencephalon" . [] oboInOwl:hasDbXref "ZFA:0000597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "telencephalic tract/commissure" . [] oboInOwl:hasDbXref "HBA:TELWM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "telencephalic white matter" . [] oboInOwl:hasDbXref "TAO:0000597" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011299 ; owl:annotatedTarget "telencephalic tracts" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011300 ; owl:annotatedTarget "A portion of gray matter that is part of a telencephalon." . [] oboInOwl:hasDbXref "BIRNLEX:1067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011300 ; owl:annotatedTarget "predominantly gray regional part of telencephalon" . ( ) . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "The deep temporalis muscle is a separable part of the temporalis muscle that that attaches to the bony wall of the braincase and is deep to the superficial temporalis." . _:genid150874 oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "medial temporal" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001683 . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "posterior temporal" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporal muscle posterior part" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporalis bbHauptmassebb" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporalis lamina profunda" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporalis pars posterior" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporalis pars profunda" . [] oboInOwl:hasDbXref "MFMO:0000086" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011306 ; owl:annotatedTarget "temporalis posterior head" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0011313 ; owl:annotatedTarget obo:UBERON_0011314 . [] oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011313 ; owl:annotatedTarget "The posterior masseter is a separable part of the deep masseter muscle that attaches to the postero-ventral surface of the zygomatic arch.[FEED]" . [] oboInOwl:hasDbXref "FEED:FEED" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011313 ; owl:annotatedTarget "masseter, posterior" . _:genid150893 oboInOwl:date_retrieved "2012-07-02" ; oboInOwl:ontology "FEED" ; oboInOwl:url "http://www.feedexp.org" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011314 ; owl:annotatedTarget "The anterior masseter is a separable part of the masseter muscle that is attached to anterior root of zygomatic arch.[FEED]" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010362 . [] oboInOwl:hasDbXref "FEED:FEED" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011314 ; owl:annotatedTarget "masseter, anterior" . (obo:UBERON_0001484 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003700 ] ) . [] oboInOwl:hasDbXref "Wikipedia:Capsule_of_temporomandibular_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011318 ; owl:annotatedTarget "The articular capsule (capsular ligament) is a thin, loose envelope, attached above to the circumference of the mandibular fossa and the articular tubercle immediately in front; below, to the neck of the condyle of the mandible." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16349403" . [] oboInOwl:hasDbXref "FMA:57050" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011318 ; owl:annotatedTarget "articular capsule of temporomandibular joint" . [] oboInOwl:hasDbXref "Wikipedia:Capsule_of_the_temporomandibular_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011318 ; owl:annotatedTarget "capsula articularis articulationis temporomandibularis" . [] oboInOwl:hasDbXref "Wikipedia:Temporomandibular_joint#Ligaments" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011320 ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "FMA:57070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011320 ; owl:annotatedTarget "temporomandibular joint ligament" . ( ) . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011321 ; owl:annotatedTarget _:genid153011 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/masseteric+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011321 ; owl:annotatedTarget "A muscular branch of the mandibular nerve passing to the medial surface of the masseter muscle, which it innervates." . [] oboInOwl:hasDbXref "Wikipedia:Masseteric_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011321 ; owl:annotatedTarget "nervus massetericus" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "A nerve that innervates the mylohyoid muscle and the anterior belly of the digastric muscle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002056 ; owl:annotatedTarget obo:CL_0000785 . [] oboInOwl:hasDbXref "FMA:53247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "branch of inferior alveolar nerve to mylohyoid" . [] oboInOwl:hasDbXref "FMA:53247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "mylodigastric nerve" . [] oboInOwl:hasDbXref "FMA:53247" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "mylohyoid branch of inferior alveolar nerve" . _:genid150923 oboInOwl:hasDbXref "FMA:53247" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "nerve to mylohyoid" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004209 . [] oboInOwl:hasDbXref "FMA:TA", "Wikipedia:Mylohyoid_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "nervus mylohyoideus" . [] oboInOwl:hasDbXref "Wikipedia:Mylohyoid_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011322 ; owl:annotatedTarget "nerve to mylohyoid" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17582343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002056 ; owl:annotatedTarget "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." . _:genid150932 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002007 ; owl:someValuesFrom obo:UBERON_0000081, obo:UBERON_0001684 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011342 ; owl:annotatedTarget "An anatomical surface that is part of a mandible." . [] oboInOwl:hasDbXref "FMA:57558" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011342 ; owl:annotatedTarget "mandibular surface" . [] oboInOwl:hasDbXref "FMA:59463" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011344 ; owl:annotatedTarget "lateral surface of mandibular ramus" . [] oboInOwl:hasDbXref "FMA:59463" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011344 ; owl:annotatedTarget "lateral surface of ramus of mandible" . [] oboInOwl:hasDbXref "FMA:59463" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011344 ; owl:annotatedTarget "external surface of ramus of mandible" . [] oboInOwl:hasDbXref "Wikipedia:Pterygomandibular_raphe" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011349 ; owl:annotatedTarget "The pterygomandibular raphe (pterygomandibular ligament) is a tendinous band of the buccopharyngeal fascia, attached by one extremity to the hamulus of the medial pterygoid plate, and by the other to the posterior end of the mylohyoid line of the mandible. Its medial surface is covered by the mucous membrane of the mouth. Its lateral surface is separated from the ramus of the mandible by a quantity of adipose tissue. Its posterior border gives attachment to the superior pharyngeal constrictor muscle. Its anterior border attaches to the posterior edge of the buccinator." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011349 ; owl:annotatedTarget "isa anatomical line in FMA" . [] oboInOwl:hasDbXref "Wikipedia:Pterygomandibular_raphe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011349 ; owl:annotatedTarget "pterygomandibular ligament" . [] oboInOwl:hasDbXref "Wikipedia:Pterygomandibular_raphe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011349 ; owl:annotatedTarget "pterygomandibular raph%c3%a9" . _:genid150946 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033, obo:UBERON_0005113 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011362 ; owl:annotatedTarget "A blood vasculature that is part of a head." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0005297" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011362 ; owl:annotatedTarget "Blood vessel part of cranial vasculature.[TAO]" . [] oboInOwl:hasDbXref "ZFA:0005297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011362 ; owl:annotatedTarget "cranial blood vessel" . _:genid150951 oboInOwl:hasDbXref "TAO:0005297" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011362 ; owl:annotatedTarget "cranial blood vessels" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003918 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "A lymph vasculature that is part of a head." . [] oboInOwl:hasDbXref "ZFA:0005298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "cranial lymph vessel" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "cranial lymphatics" . [] oboInOwl:hasDbXref "FMA:224562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "set of lymphatic vessels of head" . [] oboInOwl:hasDbXref "TAO:0005298" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "cranial lymph vessels" . [] oboInOwl:hasDbXref "FMA:224562" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011363 ; owl:annotatedTarget "set of cranial lymphatic vessels" . _:genid150968 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001445, obo:UBERON_0011368 . [] oboInOwl:hasDbXref "MURDOCH:379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011364 ; owl:annotatedTarget "The cleidomastoideus is a thick, strap-like muscle that together with the cleidocervicalis forms the proximal part of the brachiocephalicus. It lies beneath the cleidocervicalis. Its origin is the clavicular tendon with its insertion being at the mastoid process of the temporal bone. It is distinctly narrow and is united with the cleidocervicalis and cleidobrachialis by the clavicular tendon. Together with the other two components of the brachiocephalicus muscle, its primary function is to advance the free limb, however, it can also act as an shoulder extensor. Acting bilaterally, it fixes and depresses the neck, while by its unilateral action, it allows the head and neck to be drawn to the side. Its blood supply is the inferior cervical, carotid and vertebral arteries and its nerve supply is the spinal accessory, cervical and axillary nerves." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011364 ; owl:annotatedTarget "EMAPA:37687" . [] oboInOwl:source "ncithesaurus:Cleidocephalic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011364 ; owl:annotatedTarget "UMLS:C1707412" . [] oboInOwl:hasDbXref "MA:0002275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011364 ; owl:annotatedTarget "cleidocephalic" . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002059 ; owl:annotatedTarget obo:CL_0000941 . ( ) . _:genid150983 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001105, obo:UBERON_0010540 . [] oboInOwl:hasDbXref "MURDOCH:376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011366 ; owl:annotatedTarget "This muscle makes up the distal segment of the brachiocephalicus. It originates at the clavicular tendon but functionally, from the head and neck through the cleidocervicalis. It inserts at the distal end of the cranial border of the humerus, where it lies between the biceps brachii medially and the brachialis laterally. The muscle partly covers the pectoral muscles at their insertions. In conjunction with the cleidocervicalis, it advances the limb, extends the shoulder and causes lateral movement of the head and neck." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011366 ; owl:annotatedTarget "EMAPA:37686" . [] oboInOwl:source "ncithesaurus:Cleidobrachial" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011366 ; owl:annotatedTarget "UMLS:C1707411" . [] oboInOwl:hasDbXref "MA:0002274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011366 ; owl:annotatedTarget "cleidobrachial" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002059 ; owl:annotatedTarget "A conventional thymic dendritic cell that is CD8alpha-positive." . (obo:UBERON_0014892 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0000976 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0011220 ] ) . [] oboInOwl:hasDbXref "http://ccg.murdoch.edu.au/museum/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011368 ; owl:annotatedTarget "The brachiocephalicus is a long and flat, complex of muscles that extends from the lower half of the humeral shaft to the head and neck. The muscle divides into two parts at the clavicular intersection. This is also the point of origin for all the muscles that make up the brachiocephalicus. This point is situated just cranial to the shoulder. The two main sections are the cleidobrachialis which is distal to the clavicular intersection and the cleidocephalicus which extends proximally to the clavivular intersection. The cleidocephalicus can also be divided into the pars cervicalis, which inserts on the broad aponeurosis, over the fibrous raphe of the cranial half of the neck. The other part, the pars mastoideus inserts on the mastoid process of the temporal bone via a strong tendon. The cleidobrachialis extends distally from the clavicular intersection and inserts on the cranial edge of the distal half of the humerus. The tendon that inserts the cleidobrachialis lies between the brachialis muscle and the biceps brachii. As a result of the brachiocephalicus spanning a large region it has the ability to provide a number of actions. These include extending the shoulder joint, protracts the limb, provides lateral movement of the head and allows the neck to be depressed." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011368 ; owl:annotatedTarget "EMAPA:37685" . [] obo:IAO_0000116 "We need to import uberon muscle into RO to use as a stricter domain constraint" ; a owl:Axiom ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0002373 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16614889" . [] oboInOwl:source "FMA-abduced-lr" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011370 ; owl:annotatedTarget _:genid153101 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011370 ; owl:annotatedTarget "A transverse process of vertebra that is part of a vertebral bone 1." . _:genid151003 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014892 _:genid151005 [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001676 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0011220 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012151 . _:genid151005 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002208, obo:UBERON_0010699 . [] oboInOwl:notes "nuchal crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011371 ; owl:annotatedTarget _:genid153112 . [] oboInOwl:hasDbXref "MURDOCH:1749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011371 ; owl:annotatedTarget "The sternocephalicus is a flat muscle and its caudal border is adjacent to the ventral border of the brachiocephalicus. The lateral aspect of this muscle is crossed obliquely by the external jugular vein. It originates as a unit on the first sternebrae. The cranial portion of the muscle divides into two separate sections with different insertion points. These are the sternomastoideus and the sterno-occipitalis. The ventral portion, the sternomastiodeus is the stronger and main continuation of the sternocephalicus, which inserts on the mastoid part of the temporal bone. The thin but wide dorsal segment, the sterno-occipitalis attaches to the dorsal nuchal crest by a thin aponeurosis. The main action provided by the sternocephalicus is movement of the head and neck to the side. Ventral branches of the cervical nerves are attached to this muscle." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011374 ; owl:annotatedTarget "A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011375 ; owl:annotatedTarget "A zone of skin that is part of a prepuce of clitoris." . [] oboInOwl:hasDbXref "FMA:27886" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011375 ; owl:annotatedTarget "preputial skin of clitoris" . _:genid151027 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000079, obo:UBERON_0012152 . _:genid151029 oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_male_urethra" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "The external sphincter muscle of urethra (or sphincter urethrae membranaceae) surrounds the whole length of the membranous portion of the urethra, and is enclosed in the fasciæ of the urogenital diaphragm. They arch across the front of the urethra and bulbourethral glands, pass around the urethra, and behind it unite with the muscle of the opposite side, by means of a tendinous raphé." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010697 . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "MA includes a term bulboglandular - some sources claim this as the muscles that are associated with the bulbourethral gland, so we place this here" . [] oboInOwl:source "ncithesaurus:Bulboglandular" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "UMLS:C1707060" . [] oboInOwl:hasDbXref "FMA:19733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "external urethral sphincter of male urethra" . [] oboInOwl:hasDbXref "FMA:19733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "male sphincter urethrae" . [] oboInOwl:hasDbXref "FMA:19733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "male sphincter urethrae muscle" . [] oboInOwl:hasDbXref "FMA:19733" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "male urethral sphincter muscle" . [] oboInOwl:hasDbXref "FMA:19733", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "musculus sphincter urethrae externus (urethra masculina)" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_male_urethra" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "musculus sphincter urethrae externus urethrae masculinae" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_male_urethra" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "musculus sphincter urethrae membranaceae" . [] oboInOwl:hasDbXref "MA:0002273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011379 ; owl:annotatedTarget "bulboglandular" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20054144", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002062 ; owl:annotatedTarget "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "The external sphincter muscle of female urethra is a muscle which controls urination." . [] oboInOwl:hasDbXref "FMA:19778", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "musculus sphincter urethrae externus (urethra feminina)" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "musculus sphincter urethrae externus urethrae femininae" . _:genid151047 oboInOwl:hasDbXref "FMA:19778" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "outer muscle layer of female urethra" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012150 . [] oboInOwl:hasDbXref "FMA:19778" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "rhabdosphincter of female urethra" . [] oboInOwl:hasDbXref "FMA:19778" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "striated muscle layer of female urethra" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "compressor urethrae" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "sphincter urethrovaginalis" . [] oboInOwl:hasDbXref "Wikipedia:External_sphincter_muscle_of_female_urethra" ; oboInOwl:hasSynonymType core:DEPRECATED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011380 ; owl:annotatedTarget "urethrovaginal sphincter" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011386 ; owl:annotatedTarget _:genid153155 . [] oboInOwl:hasDbXref "Wikipedia:Modiolus_(face)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011386 ; owl:annotatedTarget "A chiasma of facial muscles held together by fibrous tissue, located lateral and slightly superior to each angle of the mouth. It is important in moving the mouth, facial expression and in dentistry. It derives its motor nerve supply from the facial nerve, and its blood supply from labial branches of the facial artery. It is contributed to by the following muscles: orbicularis oris, buccinator, levator anguli oris, depressor anguli oris, zygomaticus major, risorius quadratus labii superioris, quadratus labii inferioris." . [] oboInOwl:hasDbXref "MFMO:0000057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011386 ; owl:annotatedTarget "modiolus" . [] oboInOwl:hasDbXref "FMA:46837", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011386 ; owl:annotatedTarget "modiolus anguli oris" . [] oboInOwl:hasDbXref "Wikipedia:Pudendal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "The pudendal nerve is a somatic nerve in the pelvic region that innervates the external genitalia of both sexes, as well as sphincters for the bladder and the rectum. It originates in Onuf's nucleus in the sacral region of the spinal cord." . [] oboInOwl:hasDbXref "Wikipedia:Pudendal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "pudendal" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "nervus pudendae" . [] oboInOwl:hasDbXref "doi:10.1002/ca.23705" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "nervus pudendales" . [] oboInOwl:hasDbXref "Wikipedia:Pudendal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "internal pudendal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Pudendal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011390 ; owl:annotatedTarget "pudenal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Perineal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011391 ; owl:annotatedTarget "A nerve arising from the pudendal nerve that supplies the perineum." . [] oboInOwl:hasDbXref "FMA:21866" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011391 ; owl:annotatedTarget "perineal branch of pudendal nerve" . [] oboInOwl:hasDbXref "FMA:54364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011565 ; owl:annotatedTarget "gastrointestinal tract lumen" . [] oboInOwl:hasDbXref "FMA:54364" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011565 ; owl:annotatedTarget "lumen of gastrointestinal tract" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget _:genid153191 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget "An anatomical cavity that is part of a esophagus." . [] oboInOwl:hasDbXref "FMA:9398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget "cavity of esophagus" . [] oboInOwl:hasDbXref "FMA:9398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget "esophageal cavity" . [] oboInOwl:hasDbXref "FMA:9398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget "esophageal lumen" . [] oboInOwl:hasDbXref "FMA:9398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011566 ; owl:annotatedTarget "esophagus lumen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011574 ; owl:annotatedTarget "A tube lumen that is part of a mesonephric duct." . [] oboInOwl:hasDbXref "EHDAA2:0001244" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011574 ; owl:annotatedTarget "nephric duct lumen" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16664306" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011575 ; owl:annotatedTarget obo:UBERON_0004529 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011575 ; owl:annotatedTarget _:genid153205 . [] oboInOwl:hasDbXref "Wikipedia:Ulnar_styloid_process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011575 ; owl:annotatedTarget "The styloid process of the ulna projects from the medial and back part of the bone; it descends a little lower than the head, and its rounded end affords attachment to the ulnar collateral ligament of the wrist[WP,unvetted]." . [] oboInOwl:hasDbXref "FMA:TA", "Wikipedia:Ulnar_styloid_process" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011575 ; owl:annotatedTarget "processus styloideus ulnae" . [] oboInOwl:hasDbXref "FMA:23628" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011575 ; owl:annotatedTarget "ulnar styloid process" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=52809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "The superior half of the orbital rim, which constitutes the curved superior border of the orbital opening, formed by the frontal bone." . [] oboInOwl:source "Wikipedia:Neanderthal_anatomy" ; oboInOwl:taxon "NCBITaxon:63221" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "Neanderthals have a Supraorbital torus, a prominent, trabecular (spongy) brow ridge." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "see also: 'supraorbital flange'. FMA has 2 related classes, but these refer to the line and surface" . [] oboInOwl:source "ncithesaurus:Orbital_Ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "UMLS:C2826587" . [] oboInOwl:hasDbXref "FMA:53097", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "margo supraorbitalis" . [] oboInOwl:hasDbXref "FMA:317104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supra-orbital margin" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "frontal torus" . [] oboInOwl:hasDbXref "NCBITaxon:63221", "Wikipedia:Supraorbital_ridge" ; oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital torus" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "arcus superciliaris" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "eyebrow bone" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "frontal torus" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "margin of the orbit" . [] oboInOwl:hasDbXref "FMA:53097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "margo supraorbitalis (os frontale)" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911", "PMID:8540632", "http://www.copewithcytokines.de" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002063 ; owl:annotatedTarget "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "superciliary ridge" . [] oboInOwl:hasDbXref "FMA:53097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supra-orbital border of frontal bone" . [] oboInOwl:hasDbXref "FMA:53097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supra-orbital margin of frontal bone" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital arch" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital margin" . [] oboInOwl:hasDbXref "FMA:53097" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital margin of frontal bone" . [] oboInOwl:hasDbXref "FMA:57137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital surface of frontal bone" . [] oboInOwl:hasDbXref "Wikipedia:Supraorbital_ridge" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011576 ; owl:annotatedTarget "supraorbital torus" . [] oboInOwl:source "ISBN:9780878932504" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011582 ; owl:annotatedTarget _:genid153239 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011582 ; owl:annotatedTarget "The collection of all skeletal elements in an individual limb or fin." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000301" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011582 ; owl:annotatedTarget "Skeletal subdivision that is part of the paired limb/fin.[VSAO]" . [] oboInOwl:hasDbXref "VSAO:0000301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011582 ; owl:annotatedTarget "limb/fin skeleton" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget _:genid153249 . [] oboInOwl:hasDbXref "VSAO:0005007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0005007" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:NI" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO]" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "mesomere 1" . [] oboInOwl:hasDbXref "VSAO:0005007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "propodium" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "proximal metapterygial mesomere" . [] oboInOwl:hasDbXref "VSAO:0005007" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011583 ; owl:annotatedTarget "stylopod" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget _:genid153262 . [] oboInOwl:hasDbXref "VSAO:0005010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "Section of the forelimb skeleton located between the stylopodium and the autopodium." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "skeleton of zeugopod" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "zeugopod skeleton" . [] oboInOwl:hasDbXref "VSAO:0005010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "epipodium" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "mesomere 2" . [] oboInOwl:hasDbXref "ISBN:0226313409" ; oboInOwl:hasSynonymType core:HOMOLOGY ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "mesomere 2 skeleton" . [] oboInOwl:hasDbXref "VSAO:0005010" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011584 ; owl:annotatedTarget "zygopodium" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011585 ; owl:annotatedTarget obo:UBERON_0000061 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000006", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011585 ; owl:annotatedTarget "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget obo:UBERON_0010365 . [] oboInOwl:source "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget _:genid153276 . [] oboInOwl:source "text definition" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget _:genid153278 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000071", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget "Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix." . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget "pre-dentine tissue" . [] oboInOwl:hasDbXref "PMCID:PMC3360947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget "predentin" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011587 ; owl:annotatedTarget "predentine tissue" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011588 ; owl:annotatedTarget obo:UBERON_0010365 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000066", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011588 ; owl:annotatedTarget "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011588 ; owl:annotatedTarget "pre-enamel tissue" . [] oboInOwl:hasDbXref "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011588 ; owl:annotatedTarget "preenamel tissue" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011589 ; owl:annotatedTarget obo:UBERON_0002418 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget obo:CL_0000083 . [] oboInOwl:hasDbXref "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000089", "http://dx.plos.org/10.1371/journal.pone.0051070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011589 ; owl:annotatedTarget "Cartilage tissue that is not mineralized." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011590 ; owl:annotatedTarget "A commissure that is part of a diencephalon." . [] oboInOwl:hasDbXref "FMA:62445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011590 ; owl:annotatedTarget "diencephalon commissure" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget obo:CL_0000622 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011591 ; owl:annotatedTarget "An axon tract that is part of a diencephalon." . [] oboInOwl:hasDbXref "FMA:62447" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011591 ; owl:annotatedTarget "diencephalon tract" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011592 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011592 ; owl:annotatedTarget _:genid153304 . [] oboInOwl:notes "fusion" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011592 ; owl:annotatedTarget _:genid153306 . [] oboInOwl:notes "fusion" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011592 ; owl:annotatedTarget _:genid153308 . [] oboInOwl:hasDbXref "EHDAA2:0002120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011592 ; owl:annotatedTarget "upper jaw future lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:16842901" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002064 ; owl:annotatedTarget "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." . [] oboInOwl:hasDbXref "TAO:0001627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011593 ; owl:annotatedTarget "A tooth that is attached to a maxilla[TAO,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001627" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011593 ; owl:annotatedTarget "Tooth that is attached to the maxilla.[TAO]" . [] oboInOwl:hasDbXref "AAO:0000287" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011593 ; owl:annotatedTarget "maxillary teeth" . [] oboInOwl:hasDbXref "TAO:0001628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011594 ; owl:annotatedTarget "Tooth that is attached to a dentary/mandible[TAO,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001628" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011594 ; owl:annotatedTarget "Tooth that is attached to the dentary.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001628" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011594 ; owl:annotatedTarget "relationship loss: part_of dentary tooth row (TAO:0001952)[TAO]" . [] oboInOwl:hasDbXref "AAO:0000641" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011594 ; owl:annotatedTarget "mandibular teeth" . [] oboInOwl:source "EMAPA", "FMA-abduced", "ZFA-abduced" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011595 ; owl:annotatedTarget _:genid153332 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011595 ; owl:annotatedTarget "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011596 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011596 ; owl:annotatedTarget _:genid153336 . [] oboInOwl:source "Wikipedia:Mandibular_prominence" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011596 ; owl:annotatedTarget _:genid153338 . [] oboInOwl:hasDbXref "EHDAA2:0001020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011596 ; owl:annotatedTarget "lower jaw future lip" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011597 ; owl:annotatedTarget "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011601 ; owl:annotatedTarget "A gingiva that is part of a upper jaw region." . [] oboInOwl:hasDbXref "EMAPA:18970" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011601 ; owl:annotatedTarget "gum of upper jaw" . [] oboInOwl:hasDbXref "FMA:59763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011601 ; owl:annotatedTarget "upper jaw gingiva" . [] oboInOwl:hasDbXref "FMA:59763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011601 ; owl:annotatedTarget "maxillary gum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011602 ; owl:annotatedTarget "A gingiva that is part of a lower jaw region." . [] oboInOwl:hasDbXref "EMAPA:18967" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011602 ; owl:annotatedTarget "gum of lower jaw" . [] oboInOwl:hasDbXref "FMA:59764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011602 ; owl:annotatedTarget "lower jaw gingiva" . [] oboInOwl:hasDbXref "FMA:59764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011602 ; owl:annotatedTarget "lower jaw gum" . [] oboInOwl:hasDbXref "FMA:59764" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011602 ; owl:annotatedTarget "mandibular gum" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0412046911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002067 ; owl:annotatedTarget "An enteroendocrine cell that produces glucagon." . [] oboInOwl:source "TAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:source "TAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget _:genid153369 . [] oboInOwl:hasDbXref "TAO:0000672", "Wikipedia:Hyomandibula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "Replacement bone that is bilaterally paired and (in teleosts) articulates with the neurocranium dorsally and the opercle posteriorly[TAO,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "Replacement bone that is bilaterally paired and articulates with the neurocranium dorsally and the opercle posteriorly.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "relationship loss: overlaps hyomandibula-metapterygoid joint (TAO:0001979)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "relationship loss: overlaps hyomandibula-opercle joint (TAO:0005265)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "relationship loss: overlaps preopercle vertical limb-hyomandibula joint (TAO:0005278)[TAO]" . [] oboInOwl:hasDbXref "FMA:0412046911", "GOC:tfm", "PMID:19939742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002068 ; owl:annotatedTarget "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "relationship loss: overlaps quadrate-hyomandibula joint (TAO:0001801)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000688" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" . [] oboInOwl:hasDbXref "TAO:0000672" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "hyomandibula" . [] oboInOwl:hasDbXref "TAO:0000672", "Wikipedia:Hyomandibula" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011606 ; owl:annotatedTarget "hyomandibular" . [] oboInOwl:source "TAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget obo:UBERON_0011004 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget "Cartilage form of the hyomandibular element." . [] oboInOwl:hasDbXref "FMA:67101", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002072 ; owl:annotatedTarget "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001422" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget "Pharyngeal arch cartilage that is bilaterally paired and articulates with the chondrocranium dorsally, the opercle bone posteriorly, and the palatoquadrate cartilage anteriorly.[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000688" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" . [] oboInOwl:hasDbXref "ZFA:0001422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget "hyosymplectic cartilage" . [] oboInOwl:hasDbXref "TAO:0001422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011607 ; owl:annotatedTarget "symplectic cartilage" . [] oboInOwl:hasDbXref "http://en.academic.ru/dic.nsf/en_ichthyology/8715/hyomandibula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "The upper paired deep bone or cartilage of the hyoid region, sometimes taking part in jaw suspension and which supports the opercle. Dorsally it articulates with the otic capsule at the hyomandibular fossa, ventrally with the quadrate and symplectic. In most Teleostei it has a foramen for the hyomandibular branch of the facial nerve (VII)." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; oboInOwl:source "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "Replacement bone that is bilaterally paired and articulates with the neurocranium dorsally and the opercle posteriorly.[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "relationship loss: overlaps hyomandibula-metapterygoid joint (TAO:0001979)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "relationship loss: overlaps hyomandibula-opercle joint (TAO:0005265)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "relationship loss: overlaps hyomandibular-otic region joint (TAO:0001947)[TAO]" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002072 ; owl:annotatedTarget "cardiac pacemaker cell" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "relationship loss: overlaps preopercle vertical limb-hyomandibula joint (TAO:0005278)[TAO]" . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000002 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "relationship loss: overlaps quadrate-hyomandibula joint (TAO:0001801)[TAO]" . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000688" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1017/S0022215100009087 Gerrie J, The phylogeny of the mammalian tympanic cavity and auditory ossicles. The Journal of Laryngology and Otology (1948)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "This structure (the hyomandibular), on ontogenic grounds alone, can be considered homologous with the amphibian and reptilian columella and the mammalian stapes.[well established][VHOG]" . [] oboInOwl:date_retrieved "2012-09-06" ; oboInOwl:external_class "TAO:0000672" ; oboInOwl:ontology "TAO" ; oboInOwl:source "Curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000005 ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "In most teleosts, there is a symplectic, and the hyomandibula articulates with it anteroventrally.[TAO]" . [] oboInOwl:hasDbXref "VHOG:0000688" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "hyomandibula - stapes" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/bones/gill_arches/gill_arches.html" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011608 ; owl:annotatedTarget "epihyal" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011628 ; owl:annotatedTarget obo:UBERON_0007842 . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011628 ; owl:annotatedTarget _:genid153405 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011628 ; owl:annotatedTarget _:genid153407 . [] oboInOwl:hasDbXref "FMA:67142", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002073 ; owl:annotatedTarget "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011628 ; owl:annotatedTarget _:genid153409 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011641 ; owl:annotatedTarget "An odontogenic papilla that is part of a molar tooth [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011641 ; owl:annotatedTarget "molar mesenchyme" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011641 ; owl:annotatedTarget "odontogenic mesenchyme of molar tooth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:17025297" . [] oboInOwl:hasDbXref "FMA:67111", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002074 ; owl:annotatedTarget "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011642 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011642 ; owl:annotatedTarget _:genid153425 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011642 ; owl:annotatedTarget "An epithelium that develops_from a ectoderm and is part of a oral epithelium." . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011645 ; owl:annotatedTarget "Limb extensor that runs from ilium to femur." . [] oboInOwl:hasDbXref "TAO:0000236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011648 ; owl:annotatedTarget "mandibular muscle" . [] oboInOwl:hasDbXref "TAO:0000236" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011648 ; owl:annotatedTarget "mandibular muscles" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011676 ; owl:annotatedTarget "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." . [] oboInOwl:hasDbXref "FMA:69075", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002076 ; owl:annotatedTarget "An epithelial cell derived from endoderm." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011677 ; owl:annotatedTarget obo:UBERON_0004451 . [] oboInOwl:hasDbXref "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011677 ; owl:annotatedTarget "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011677 ; owl:annotatedTarget "presacral vertebra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011678 ; owl:annotatedTarget "A proximal tarsal bone that articulates with the fibula." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011678 ; owl:annotatedTarget "intermedium" . [] oboInOwl:hasDbXref "AAO:0000923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011678 ; owl:annotatedTarget "intermedium (hind)" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011678 ; owl:annotatedTarget "intermedium of pes" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011678 ; owl:annotatedTarget "pedal intermedium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011679 ; owl:annotatedTarget "A tarsal bone that connected_to a hindlimb zeugopod skeleton." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011695 ; owl:annotatedTarget "A cardiovascular system that is part of a conceptus." . [] oboInOwl:hasDbXref "MA:0003179" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011741 ; owl:annotatedTarget "valve leaflet" . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011742 ; owl:annotatedTarget _:genid153469 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011742 ; owl:annotatedTarget "A cardiac valve leaflet that is part of a aortic valve." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000819" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011742 ; owl:annotatedTarget "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" . [] oboInOwl:hasDbXref "VHOG:0000819" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011742 ; owl:annotatedTarget "aortic valve leaflets" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011745 ; owl:annotatedTarget "A cardiac valve leaflet that is part of a pulmonary valve." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0000820" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0011745 ; owl:annotatedTarget "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011754 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:hasDbXref "Wikipedia:Labioscrotal_swelling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011754 ; owl:annotatedTarget "Paired structures in the embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. In both males and females the two swellings merge: in the female, they become the posterior labial commissure; In the male, they become the scrotum." . [] oboInOwl:hasDbXref "Wikipedia:Labioscrotal_swelling" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011754 ; owl:annotatedTarget "tuberculum labioscrotale" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011755 ; owl:annotatedTarget "A genital swelling that is part of a female reproductive system." . [] oboInOwl:hasDbXref "EMAPA:18329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011755 ; owl:annotatedTarget "labial swelling" . [] oboInOwl:hasDbXref "EMAPA:30423" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011755 ; owl:annotatedTarget "labioscrotal swelling of female" . [] oboInOwl:hasDbXref "FMA:69074", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002077 ; owl:annotatedTarget "An epithelial cell derived from ectoderm." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011756 ; owl:annotatedTarget "A genital swelling that is part of a male reproductive organ." . [] oboInOwl:hasDbXref "EMAPA:30509" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011756 ; owl:annotatedTarget "labioscrotal swelling of male" . [] oboInOwl:hasDbXref "Wikipedia:Primordial_phallus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011757 ; owl:annotatedTarget "." . [] oboInOwl:source "ncithesaurus:Primordial_Phallus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011757 ; owl:annotatedTarget "UMLS:C1514448" . [] oboInOwl:hasDbXref "Wikipedia:Primordial_phallus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011757 ; owl:annotatedTarget "phallus" . [] oboInOwl:hasDbXref "Wikipedia:Primordial_phallus" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011757 ; owl:annotatedTarget "phallus primordialis" . [] oboInOwl:hasDbXref "Wikipedia:Primordial_phallus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011757 ; owl:annotatedTarget "primordial phallus" . [] oboInOwl:hasDbXref "EMAPA:25350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011766 ; owl:annotatedTarget "left recurrent laryngeal branch" . [] oboInOwl:hasDbXref "FMA:14469" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011766 ; owl:annotatedTarget "left recurrent laryngeal nerve" . [] oboInOwl:hasDbXref "MA:0001107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011766 ; owl:annotatedTarget "vagus X nerve left recurrent laryngeal branch" . [] oboInOwl:hasDbXref "EMAPA:17275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011767 ; owl:annotatedTarget "right recurrent laryngeal branch" . [] oboInOwl:hasDbXref "FMA:14468" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011767 ; owl:annotatedTarget "right recurrent laryngeal nerve" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "MA:0001108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011767 ; owl:annotatedTarget "vagus X nerve right recurrent laryngeal branch" . [] oboInOwl:hasDbXref "VSAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011769 ; owl:annotatedTarget "Anatomical projection that is composed of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011772 ; owl:annotatedTarget "An anatomical space that is part of a bone of lower jaw." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011773 ; owl:annotatedTarget "An anatomical space that is part of a bone of upper jaw." . [] oboInOwl:hasDbXref "FMA:69076", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002078 ; owl:annotatedTarget "Epithelial cell derived from mesoderm or mesenchyme." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "A cranial nerve nucleus that is associated with a vagus nerve." . [] oboInOwl:hasDbXref "FMA:54573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "nucleus of vagus nerve" . [] oboInOwl:hasDbXref "FMA:54573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "tenth cranial nerve nucleus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "vagal X nucleus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "vagal nucleus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "vagus nucleus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011775 ; owl:annotatedTarget "nodosal nucleus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011777 ; owl:annotatedTarget "A neural nucleus that is part of the spinal cord." . [] oboInOwl:hasDbXref "FMA:77011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011777 ; owl:annotatedTarget "spinal cord nucleus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011779 ; owl:annotatedTarget "A nerve that is part of a head." . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011814 ; owl:annotatedTarget obo:UBERON_0005085 . [] oboInOwl:hasDbXref "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011814 ; owl:annotatedTarget "Ectodermal placode that does not develop into a component of the nervous system." . [] oboInOwl:source "NCBIBook:NBK53175" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011817 ; owl:annotatedTarget obo:UBERON_0011814 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011817 ; owl:annotatedTarget "An ectodermal placode that gives rise to any of the cutaneous appendages that protrude from the skin epidermis (heair, feathers, epidermal scales)." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011818 ; owl:annotatedTarget _:genid153573 . [] oboInOwl:hasDbXref "Wikipedia:Superficial_fascia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011818 ; owl:annotatedTarget "Superficial fascia is found in the subcutis in most regions of the body, blending with the reticular layer of the dermis. It is present on the face, over the upper portion of the sternocleidomastoid, at the nape of the neck, and overlying the sternum. It is comprised mainly of loose areolar connective tissue and adipose and is the layer that primarily determines the shape of a body. In addition to its subcutaneous presence, this type of fascia surrounds organs and glands, neurovascular bundles, and is found at many other locations where it fills otherwise unoccupied space. It serves as a storage medium of fat and water; as a passageway for lymph, nerve and blood vessels; and as a protective padding to cushion and insulate. Superficial fascia is present, but does not contain fat, in the eyelids, ear, scrotum, penis and clitoris." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011818 ; owl:annotatedTarget "we follow FMA, BTO, NCIT and WP in making this a distinct class from hypodermis." . [] oboInOwl:hasDbXref "FMA:9630" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011818 ; owl:annotatedTarget "subcutaneous tissue" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011818 ; owl:annotatedTarget "tela subcutanea" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011819 ; owl:annotatedTarget obo:UBERON_0005082 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011819 ; owl:annotatedTarget "A tube lumen that is part of a atrioventricular canal." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." . [] oboInOwl:hasDbXref "PMID:21234997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "AV region" . [] oboInOwl:hasDbXref "PMID:21234997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "AV segment" . _:genid151474 oboInOwl:hasDbXref "GO:0003294" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "atrial ventricular junction" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012151 . [] oboInOwl:hasDbXref "FMA:85125", "GO:0003294" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "atrioventricular junction" . [] oboInOwl:hasDbXref "PMID:21234997" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011820 ; owl:annotatedTarget "atrioventricular segment" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011821 ; owl:annotatedTarget obo:UBERON_0002384 . [] oboInOwl:hasDbXref "FMA:20107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011821 ; owl:annotatedTarget "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011822 ; owl:annotatedTarget obo:UBERON_0011821 . [] oboInOwl:hasDbXref "FMA:20109", "Wikipedia:Dense_irregular_connective_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011822 ; owl:annotatedTarget "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." . [] oboInOwl:date_retrieved "2012-08-29" ; oboInOwl:external_class "ncithesaurus:Irregular_Dense_Connective_Tissue" ; oboInOwl:ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011822 ; owl:annotatedTarget "Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT]" . [] oboInOwl:source "ncithesaurus:Irregular_Dense_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011822 ; owl:annotatedTarget "UMLS:C0738366" . [] oboInOwl:hasDbXref "FMA:20109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011822 ; owl:annotatedTarget "typus irregularis (textus connectivus collagenosus compactus)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget obo:CL_0000083 . [] oboInOwl:hasDbXref "Wikipedia:Dense_connective_tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011823 ; owl:annotatedTarget "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets." . [] oboInOwl:date_retrieved "2012-08-29" ; oboInOwl:external_class "ncithesaurus:Dense_Connective_Tissue" ; oboInOwl:ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011823 ; owl:annotatedTarget "Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT]" . [] oboInOwl:source "ncithesaurus:Dense_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011823 ; owl:annotatedTarget "UMLS:C1511770" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011824 ; owl:annotatedTarget obo:UBERON_0011822 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011825 ; owl:annotatedTarget obo:UBERON_0011821 . [] oboInOwl:hasDbXref "FMA:19783" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011825 ; owl:annotatedTarget "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:17569513" . [] oboInOwl:hasDbXref "FMA:63099", "GOC:tfm", "PMID:14740223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002079 ; owl:annotatedTarget "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." . [] oboInOwl:source "ncithesaurus:Loose_Connective_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011825 ; owl:annotatedTarget "UMLS:C1253917" . [] oboInOwl:hasDbXref "FMA:19783", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011825 ; owl:annotatedTarget "textus connectivus collagenosus laxus" . [] oboInOwl:hasDbXref "FMA:19783", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011825 ; owl:annotatedTarget "textus connectivus laxus" . [] oboInOwl:hasDbXref "Wikipedia:Areolar_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "A sebaceous glands in the areola surrounding the nipple." . _:genid151508 oboInOwl:source "FMA:58090" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "Lobular organ the parenchyma of which consists of acini connected to the surface of the areola or to a lactiferous duct by the duct of areolar gland. Examples: There are variable numbers of areolar glands[FMA:58090]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012152 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "EMAPA:37668" . [] oboInOwl:source "ncithesaurus:Montgomery_s_Tubercle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "UMLS:C0929386" . [] oboInOwl:hasDbXref "FMA:58090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "accessory gland of Montgomery" . [] oboInOwl:hasDbXref "FMA:58090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "accessory gland of breast" . [] oboInOwl:hasDbXref "MA:0000794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011827 ; owl:annotatedTarget "mammary gland sebaceous gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011845 ; owl:annotatedTarget "A duct that is part of a sebaceous gland." . [] oboInOwl:hasDbXref "FMA:70947" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011845 ; owl:annotatedTarget "sebaceous gland duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011846 ; owl:annotatedTarget "An acinus that is part of a sebaceous gland." . [] oboInOwl:hasDbXref "FMA:59657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011846 ; owl:annotatedTarget "sebaceous gland acinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011847 ; owl:annotatedTarget "An acinus that is part of a parotid gland." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011847 ; owl:annotatedTarget "EMAPA:37933" . [] oboInOwl:hasDbXref "FMA:59863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011847 ; owl:annotatedTarget "parotid gland acinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011850 ; owl:annotatedTarget "An acinus that is part of a salivary gland." . [] oboInOwl:hasDbXref "FMA:59870" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011850 ; owl:annotatedTarget "salivary gland acinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011854 ; owl:annotatedTarget "An acinus that is part of a areolar gland." . _:genid151544 oboInOwl:hasDbXref "FMA:62081" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011854 ; owl:annotatedTarget "areolar gland acinus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010702 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011856 ; owl:annotatedTarget "An acinus that is part of a mammary gland." . [] oboInOwl:hasDbXref "FMA:74438" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011856 ; owl:annotatedTarget "lactiferous gland acinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011857 ; owl:annotatedTarget "An acinus that is part of a lacrimal gland." . [] oboInOwl:hasDbXref "FMA:85250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011857 ; owl:annotatedTarget "lacrimal gland acinus" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011858 ; owl:annotatedTarget "An acinus that is part of a exocrine gland." . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget _:genid153686 . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "The internal auditory meatus (also internal acoustic meatus, internal auditory canal, and internal acoustic canal) is a canal in the petrous bone of the temporal bone of the skull that carries nerves from inside the cranium towards the middle and inner ear compartments namely cranial nerve VII and cranial nerve VIII." . [] oboInOwl:source "ncithesaurus:Internal_Auditory_Canal_of_Ear" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "UMLS:C0149591" . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "internal acoustic canal" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget obo:CL_0000083 . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "internal acoustic meatus" . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "internal auditory canal" . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "internal auditory meatus" . [] oboInOwl:hasDbXref "Wikipedia:Internal_auditory_meatus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011859 ; owl:annotatedTarget "porus acusticus internus" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011860 ; owl:annotatedTarget obo:UBERON_0000476 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011860 ; owl:annotatedTarget "the FMA class specifically refers to ureter" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12142741", "PMID:20018761", "PMID:8185160" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002080 ; owl:annotatedTarget "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." . [] oboInOwl:hasDbXref "MP:0011640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011861 ; owl:annotatedTarget "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:hasDbXref "MP:0011641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011862 ; owl:annotatedTarget "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:hasDbXref "MP:0011642" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011863 ; owl:annotatedTarget "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:17737668" . [] oboInOwl:hasDbXref "MP:0011643" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011864 ; owl:annotatedTarget "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:hasDbXref "MP:0011650" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011865 ; owl:annotatedTarget "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011871 ; owl:annotatedTarget "A cranial suture that connects a nasal bone and connects a maxilla." . [] oboInOwl:hasDbXref "FMA:52960" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011871 ; owl:annotatedTarget "nasomaxillary suture of skull" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011875 ; owl:annotatedTarget "A skeletal ligament that is part of a sternoclavicular joint." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011875 ; owl:annotatedTarget "ligamentum sternoclavicularis" . [] oboInOwl:hasDbXref "FMA:63980" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011875 ; owl:annotatedTarget "sternoclavicular joint ligament" . _:genid151622 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0007371 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0007373 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 . [] oboInOwl:hasDbXref "http://www.drugs.com/dict/margin-of-tongue.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011877 ; owl:annotatedTarget "The lateral border that separates the dorsum from the inferior surface of the tongue on each side, the two borders meeting anteriorly at the apex.." . _:genid151630 oboInOwl:hasDbXref "http://www.drugs.com/dict/margin-of-tongue.html" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011877 ; owl:annotatedTarget "margo linguae" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:hasDbXref "FMA:54650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011877 ; owl:annotatedTarget "tongue margin" . _:genid151632 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001043 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006247 . [] oboInOwl:notes "upper part" ; oboInOwl:source "Wikipedia:Muscular_layer" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget _:genid153761 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "A muscle layer that is part of a wall of esophagus." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "In the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle" . [] oboInOwl:hasDbXref "FMA:62998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "muscle coat of esophagus" . _:genid151641 oboInOwl:hasDbXref "FMA:62998" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "muscular coat of oesophagus" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007832 . [] oboInOwl:hasDbXref "FMA:62998" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "muscular layer of oesophagus" . _:genid151643 oboInOwl:hasDbXref "FMA:62998", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "tela muscularis (oesophagus)" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006285 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "tunica muscularis esophagi" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011878 ; owl:annotatedTarget "tunica muscularis oesophageae" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002082 ; owl:annotatedTarget obo:CL_0000336 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget _:genid153772 . [] oboInOwl:hasDbXref "MP:0005194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget "EMAPA:37417" . [] oboInOwl:hasDbXref "MP:0005194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget "Haller tunica vascula" . [] oboInOwl:hasDbXref "MP:0005194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget "tunica vasculosa bulbosa" . [] oboInOwl:hasDbXref "MP:0005194" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011892 ; owl:annotatedTarget "vasculosa oculi" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002082 ; owl:annotatedTarget "A chromaffin cell of the adrenal medulla that produces epinephrine." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011894 ; owl:annotatedTarget "An organ cavity that is part of a vagina." . [] oboInOwl:hasDbXref "FMA:19982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011894 ; owl:annotatedTarget "vaginal lumen" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget obo:UBERON_0011822 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget _:genid153791 . [] oboInOwl:hasDbXref "Wikipedia:Epimysium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." . [] oboInOwl:source "ncithesaurus:Epimysium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget "UMLS:C0504096" . [] oboInOwl:hasDbXref "FMA:9726" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget "fascia of muscle organ" . [] oboInOwl:hasDbXref "Wikipedia:Epimysium" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011899 ; owl:annotatedTarget "epimysia" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget obo:UBERON_0006800 . [] oboInOwl:source "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget _:genid153801 . [] oboInOwl:hasDbXref "MP:0006250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "The thickened peripheral margin of the vitreous membrane of the cornea." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "A line in FMA, a structure in MP" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "EMAPA:37895" . [] oboInOwl:hasDbXref "FMA:58422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "Schwalbe line" . [] oboInOwl:hasDbXref "FMA:58422" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "Schwalbe's line" . [] oboInOwl:hasDbXref "MP:0006250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011918 ; owl:annotatedTarget "Schwalbe's ring" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011919 ; owl:annotatedTarget _:genid153814 . [] oboInOwl:hasDbXref "MP:0011204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011919 ; owl:annotatedTarget "Masses of developing blood cells attached to endothelium in the yolk sac." . [] oboInOwl:hasDbXref "MP:0011204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011919 ; owl:annotatedTarget "visceral yolk sac blood island" . [] oboInOwl:hasDbXref "EHDAA2:0000177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011919 ; owl:annotatedTarget "yolk sac blood islands" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget obo:UBERON_0007503 . _:genid151691 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget _:genid153820 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009191 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget _:genid153822 . _:genid151693 oboInOwl:external_ontology "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget "in EHDAA2 gives rise to connecting stalk blood vessels and extraembryonic umbilical vessels" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006904 . [] oboInOwl:hasDbXref "Wikipedia:Blood_island" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget "blood island of umbilical vesicle" . [] oboInOwl:hasDbXref "Wikipedia:Blood_island" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011921 ; owl:annotatedTarget "insula sanguinea vesiculae umbilicalis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:18670398" . [] oboInOwl:hasDbXref "MP:0004598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011922 ; owl:annotatedTarget "The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011922 ; owl:annotatedTarget "EMAPA:37830" . [] oboInOwl:hasDbXref "MESH:A08.663.542.122", "Wikipedia:Preganglionic_nerve_fibers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011925 ; owl:annotatedTarget "Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released." . [] oboInOwl:hasDbXref "FMA:5923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011925 ; owl:annotatedTarget "preganglionic nerve fiber" . [] oboInOwl:hasDbXref "MP:0008310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011927 ; owl:annotatedTarget "A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion." . [] oboInOwl:hasDbXref "MP:0008310" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011927 ; owl:annotatedTarget "sympathetic preganglionic fiber" . [] oboInOwl:hasDbXref "MP:0008311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011930 ; owl:annotatedTarget "A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion." . _:genid151728 oboInOwl:hasDbXref "MP:0008311" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011930 ; owl:annotatedTarget "parasympathetic preganglionic fiber" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002091 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002083 ; owl:annotatedTarget obo:CL_0000336 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_hair" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011931 ; owl:annotatedTarget "Hair in the nose." . [] oboInOwl:hasDbXref "FMA:53670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011931 ; owl:annotatedTarget "hair of nose" . [] oboInOwl:hasDbXref "FMA:53670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011931 ; owl:annotatedTarget "hair of vestibular part of nose" . [] oboInOwl:hasDbXref "FMA:53670" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011931 ; owl:annotatedTarget "nose hair" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002083 ; owl:annotatedTarget "A chromaffin cell of the adrenal medulla that produces norepinephrine." . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011932 ; owl:annotatedTarget _:genid153868 . [] oboInOwl:hasDbXref "ISBN:0123813611", "PMCID:PMC3130146", "Wikipedia:Pilosebaceous_unit" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011932 ; owl:annotatedTarget "An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle." . [] oboInOwl:hasDbXref "Wikipedia:Pilosebaceous_unit" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011932 ; owl:annotatedTarget "fabrica pilosebacea" . [] oboInOwl:hasDbXref "FMA:70661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011932 ; owl:annotatedTarget "pilo-sebaceous apparatus" . [] oboInOwl:hasDbXref "FMA:70661" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011932 ; owl:annotatedTarget "pilosebaceous gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011953 ; owl:annotatedTarget "A region of the stomach that is lined with glandular epithelium." . [] oboInOwl:hasDbXref "FMA:67968", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002086 ; owl:annotatedTarget "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." . [] oboInOwl:source "ncithesaurus:Glandular_Stomach" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011953 ; owl:annotatedTarget "UMLS:C0227197" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011955 ; owl:annotatedTarget "A hepatic vein that is part of a left lobe of liver." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011955 ; owl:annotatedTarget "EMAPA:37164" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011956 ; owl:annotatedTarget "A hepatic vein that is part of a right lobe of liver." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0011956 ; owl:annotatedTarget "EMAPA:37377" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011960 ; owl:annotatedTarget "An articular capsule that is part of the glenohumeral joint." . [] oboInOwl:hasDbXref "Wikipedia:Articular_capsule_of_the_humerus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011960 ; owl:annotatedTarget "articular capsule of humerus" . [] oboInOwl:hasDbXref "FMA:34944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011960 ; owl:annotatedTarget "capsule of shoulder joint" . [] oboInOwl:hasDbXref "FMA:34944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011960 ; owl:annotatedTarget "fibrous capsule of glenohumeral joint" . [] oboInOwl:hasDbXref "FMA:34944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011960 ; owl:annotatedTarget "glenohumeral joint capsule" . _:genid151773 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001484 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001486 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010744 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011961 ; owl:annotatedTarget "An articular capsule that is part of the hip joint." . [] oboInOwl:hasDbXref "Wikipedia:Capsule_of_hip_joint" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011961 ; owl:annotatedTarget "capsula articularis coxae" . [] oboInOwl:hasDbXref "Wikipedia:Capsule_of_hip_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011961 ; owl:annotatedTarget "capsule of hip joint" . [] oboInOwl:hasDbXref "FMA:42821" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011961 ; owl:annotatedTarget "fibrous capsule of hip joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011962 ; owl:annotatedTarget obo:UBERON_0011139 . [] oboInOwl:hasDbXref "Wikipedia:Transverse_tarsal_joint" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011962 ; owl:annotatedTarget "The transverse tarsal joint is formed by the articulation of the calcaneus with the cuboid, and the articulation of the talus with the navicular. The movement which takes place in this joint is more extensive than that in the other tarsal joints, and consists of a sort of rotation by means of which the foot may be slightly flexed or extended, the sole being at the same time carried medially (inverted) or laterally." . [] oboInOwl:hasDbXref "Wikipedia:Transverse_tarsal_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011962 ; owl:annotatedTarget "articulatio tarsi transversa" . [] oboInOwl:hasDbXref "FMA:35201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011962 ; owl:annotatedTarget "chopart's joint" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_tarsal_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011962 ; owl:annotatedTarget "midtarsal joint" . ( ) . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011963 ; owl:annotatedTarget _:genid153928 . [] oboInOwl:hasDbXref "Wikipedia:Talocalcaneonavicular_articulation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011963 ; owl:annotatedTarget "The talocalcaneonavicular articulation is an arthrodial joint: the rounded head of the talus being received into the concavity formed by the posterior surface of the navicular, the anterior articular surface of the calcaneus, and the upper surface of the plantar calcaneonavicular ligament. There are two ligaments in this joint: the articular capsule and the dorsal talonavicular." . [] oboInOwl:hasDbXref "Wikipedia:Talocalcaneonavicular_articulation" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011963 ; owl:annotatedTarget "articulatio talocalcaneonavicularis" . [] oboInOwl:hasDbXref "Wikipedia:Talocalcaneonavicular_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011963 ; owl:annotatedTarget "talocalcaneonavicular articulation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22002069" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002087 ; owl:annotatedTarget obo:CL_0000738 . _:genid151802 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001450, obo:UBERON_0004339 . [] oboInOwl:source "FMA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011964 ; owl:annotatedTarget _:genid153939 . [] oboInOwl:hasDbXref "Wikipedia:Calcaneocuboid_articulation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011964 ; owl:annotatedTarget "Calcaneocuboid Articulation (articulation of the calcaneus with the cuboid). The ligaments connecting the calcaneus with the cuboid are five in number, viz. , the articular capsule, the dorsal calcaneocuboid, part of the bifurcated, the long plantar, and the plantar calcaneocuboid." . [] oboInOwl:hasDbXref "FMA:35207" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011964 ; owl:annotatedTarget "articulatio calcaneocubiodea" . [] oboInOwl:hasDbXref "Wikipedia:Calcaneocuboid_articulation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011964 ; owl:annotatedTarget "calcaneocuboid articulation" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002087 ; owl:annotatedTarget "A leukocyte that lacks granules." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011968 ; owl:annotatedTarget obo:UBERON_0001491 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011968 ; owl:annotatedTarget "A skeletal joint that connects a radius bone and connects a carpal skeleton." . [] oboInOwl:hasDbXref "FMA:35291" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0011968 ; owl:annotatedTarget "wrist joint" . [] oboInOwl:hasDbXref "Wikipedia:Wrist" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011968 ; owl:annotatedTarget "articulatio radiocarpea" . [] oboInOwl:hasDbXref "Wikipedia:Wrist" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011968 ; owl:annotatedTarget "radiocarpal articulation" . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/glossary/glossaryM.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011969 ; owl:annotatedTarget "An ankle joint that passes between the proximal and distal tarsals." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011970 ; owl:annotatedTarget "A skeletal ligament that connects the fibula to the talus. Examples: anterior and posterior talofibular ligament." . [] oboInOwl:hasDbXref "Wikipedia:Talofibular_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011970 ; owl:annotatedTarget "ligamentum talofibulare" . [] oboInOwl:hasDbXref "Wikipedia:Calcaneofibular_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011971 ; owl:annotatedTarget "A skeletal ligament that connects the fibula to the calcaneus." . [] oboInOwl:source "WP,modified" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0011971 ; owl:annotatedTarget "In humans, it is a narrow, rounded cord, running from the apex of the fibular malleolus downward and slightly backward to a tubercle on the lateral surface of the calcaneus. It is covered by the tendons of the Peronæi longus and brevis." . [] oboInOwl:hasDbXref "Wikipedia:Calcaneofibular_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011971 ; owl:annotatedTarget "ligamentum calcaneofibulare" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "A skeletal ligament that connects a tibia and connects a tarsal skeleton." . [] oboInOwl:hasDbXref "FMA:44055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "deltoid collateral ligament of ankle joint" . [] oboInOwl:hasDbXref "FMA:44055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "deltoid ligament of ankle joint" . [] oboInOwl:hasDbXref "FMA:44055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "ligamentum collaterale mediale (articulatio talocruralis)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002092 ; owl:annotatedTarget obo:CL_0001035 . [] oboInOwl:hasDbXref "FMA:44055", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "ligamentum collaterale mediale articulationis talocruralis" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "ligamentum deltoideum" . [] oboInOwl:hasDbXref "FMA:44055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "ligamentum deltoideum (articulatio talocruralis)" . [] oboInOwl:hasDbXref "FMA:44055" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0011972 ; owl:annotatedTarget "medial collateral ligament of ankle joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011973 ; owl:annotatedTarget "An epiphysis that is part of a phalanx of a pes [Automatically generated definition]." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002092 ; owl:annotatedTarget "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." . _:genid151871 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327, obo:UBERON_0003868 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011974 ; owl:annotatedTarget "An epiphysis that is part of a proximal phalanx of pes." . _:genid151874 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003866 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006287 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011975 ; owl:annotatedTarget "An epiphysis that is part of a middle phalanx of pes." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002095 ; owl:annotatedTarget "A cell in the hilum of the ovary that produces androgens." . _:genid151881 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327, obo:UBERON_0003867 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011976 ; owl:annotatedTarget "An epiphysis that is part of a distal phalanx of pes." . _:genid151884 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001437 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002234 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006287 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011977 ; owl:annotatedTarget "An epiphysis that is part of a proximal phalanx of manus." . _:genid151891 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003327, obo:UBERON_0003864 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011978 ; owl:annotatedTarget "An epiphysis that is part of a middle phalanx of manus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011979 ; owl:annotatedTarget "An epiphysis that is part of a distal phalanx of manus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22081570" . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Crurotarsal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011980 ; owl:annotatedTarget "A joint that connects the bones of the crus to the proximal tarsal bones." . [] oboInOwl:source "http://palaeos.com/vertebrates/glossary/glossaryCr.html#Crurotarsal%20joint" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0011980 ; owl:annotatedTarget "an ankle joint that passes between the astragalus and calcaneum[Palaeos]." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0011997 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Body_cavity", "Wikipedia:Coelom" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0011997 ; owl:annotatedTarget "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." . [] oboInOwl:source "Wikipedia:Acoelomorpha" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002161 ; owl:annotatedSource obo:UBERON_0011997 ; owl:annotatedTarget obo:NCBITaxon_147099 . [] oboInOwl:hasDbXref "NCBITaxon:33511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0011997 ; owl:annotatedTarget "enterocoelom" . _:genid151911 oboInOwl:hasDbXref "EHDAA2:0004731" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0011997 ; owl:annotatedTarget "coelomic cavity" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005259 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/myocoele" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012054 ; owl:annotatedTarget "The cavity within a myotome." . [] oboInOwl:date_retrieved "2012-09-17" ; oboInOwl:external_class "VHOG:0001283" ; oboInOwl:ontology "VHOG" ; oboInOwl:source "ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.166 and Figure 5.6", "http://bgee.unil.ch/" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000003 ; owl:annotatedSource obo:UBERON_0012054 ; owl:annotatedTarget "The central cavity within the mesoderm is the paired primary or embryonic coelom. Parts of the embryonic coelom often become enclosed in the mesoderm, forming a myocoel within the epimere, a nephrocoel within the mesomere, and simple coelom (body cavity) within the lateral plate mesoderm.[well established][VHOG]" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012069 ; owl:annotatedTarget obo:UBERON_0001744 . (obo:UBERON_0001091 [ a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0012071 ] ) . [] oboInOwl:hasDbXref "http://palaeos.com/vertebrates/therapsida/anteosauria.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012070 ; owl:annotatedTarget "A tooth that is on the roof of the mouth." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012070 ; owl:annotatedTarget "palatal teeth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002097 ; owl:annotatedTarget obo:CL_0002078 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012071 ; owl:annotatedTarget "Any bone that is part of a palate." . _:genid151932 oboInOwl:source "MA:th" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012071 ; owl:annotatedTarget "EMAPA:37930" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005259 . [] oboInOwl:source "ncithesaurus:Palate_Bone" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012071 ; owl:annotatedTarget "UMLS:C1518857" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012072 ; owl:annotatedTarget "dermatocranium, palatal series" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012072 ; owl:annotatedTarget "palatal series" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002097 ; owl:annotatedTarget "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012073 ; owl:annotatedTarget "A tooth that is attached to a palatine bone." . [] oboInOwl:source "http://www.fishbase.org/glossary/Glossary.php?q=palatine+teeth" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0012073 ; owl:annotatedTarget "Teeth present in some fishes on the palatine bones, bones that lie inside the upper jaw bones (sometimes maxillaries, sometimes premaxillaries) usually behind the vomerine tooth patch." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012073 ; owl:annotatedTarget "palatine teeth" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget _:genid154083 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget "A subdivision of skeletal system that subdivision_of a hard palate." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget "EMAPA:37444" . [] oboInOwl:hasDbXref "FMA:59857" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget "bony palate" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget "hard palate skeleton" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012074 ; owl:annotatedTarget "palatum osseum" . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget obo:UBERON_0010522 . [] oboInOwl:hasDbXref "ZFA:0001628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget "Bone that forms as a replacement of another structural tissue." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "TAO:0001637" ; oboInOwl:ontology "TAO" ; oboInOwl:source "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget "Bone that forms as a replacement of another structural tissue.[TAO]" . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget "This class was introduced to be consistent with the ZFA hierarchy. The corresponding TAO term was obsoleted, and never introduced into VSAO. Note that VSAO does have replacement element." . [] oboInOwl:hasDbXref "ZFA:0001628" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012075 ; owl:annotatedTarget "replacement bones" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012076 ; owl:annotatedTarget "A skeletal joint that connects a tibia and connects a talus." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012076 ; owl:annotatedTarget "see also FMA:44063 ! tibiotalar part of medial ligament of ankle joint" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0012076 ; owl:annotatedTarget "ankle joint" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0012076 ; owl:annotatedTarget "talotibial joint" . [] oboInOwl:hasDbXref "Wikipedia:Ankle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0012076 ; owl:annotatedTarget "tibioastragalar joint" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012080 ; owl:annotatedTarget "A cartilaginous condensation that has the potential to develop into a patella." . _:genid151981 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005866 _:genid151983 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 . _:genid151983 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002387 ; owl:someValuesFrom obo:UBERON_0002446, obo:UBERON_0016611 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012081 ; owl:annotatedTarget _:genid154121 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012081 ; owl:annotatedTarget "A pre-cartilage condensation that has the potential to develop into a patella." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002101 ; owl:annotatedTarget obo:CL_0000788 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0012082 ; owl:annotatedTarget _:genid154124 . _:genid151992 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012082 ; owl:annotatedTarget _:genid154129 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014792 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012082 ; owl:annotatedTarget "An anatomical cavity that is part of a bronchus." . [] oboInOwl:hasDbXref "FMA:62646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012082 ; owl:annotatedTarget "bronchial lumen" . [] oboInOwl:hasDbXref "FMA:62646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012082 ; owl:annotatedTarget "lumen of bronchus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22088435" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002101 ; owl:annotatedTarget "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012102 ; owl:annotatedTarget "A salivary gland that is part of a cheek." . _:genid152005 oboInOwl:hasDbXref "UBERON:cjm", "Wikipedia:Diastema_(dentistry)" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012111 ; owl:annotatedTarget "A space or gap between two teeth." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0014793 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012111 ; owl:annotatedTarget "diastemata" . [] oboInOwl:notes "editor note: add cartilage precursors and infer this" ; oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget obo:UBERON_0002513 . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget _:genid154146 . [] oboInOwl:hasDbXref "AAO:0000913" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget "One of two elements that constitute the basal row of tarsals. The fibulare constitutes the preaxial element[AAO]." . [] oboInOwl:date_retrieved "2012-06-20" ; oboInOwl:external_class "AAO:0000913" ; oboInOwl:ontology "AAO" ; oboInOwl:source "AAO:LAP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget "One of two element that constitute the basal row of tarsals. The fibulare constitutes the preaxial element. In salamanders this element is aproximatelly rounded, whereas in anurans it is an elongate, cylindrical bone with the proximal and distal heads fused to the heads of the tibiale.[AAO]" . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget "In salamanders this element is aproximatelly rounded, whereas in anurans it is an elongate, cylindrical bone with the proximal and distal heads fused to the heads of the tibiale" . [] oboInOwl:hasDbXref "AAO:0000913" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012126 ; owl:annotatedTarget "astragalus" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget _:genid154153 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "Outermost point on an external nose or snout." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "EMAPA:37915" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "apex nasi" . [] oboInOwl:hasDbXref "FMA:59518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "apex of nose" . [] oboInOwl:hasDbXref "FMA:59518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "nasal tip" . [] oboInOwl:hasDbXref "FMA:59518" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "tip of nose" . [] oboInOwl:hasDbXref "https://www.abdn.ac.uk/bestiary/translat/84v.hti" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012128 ; owl:annotatedTarget "pirula" . [] oboInOwl:hasDbXref "PHENOSCAPE:AMAO", "https://github.com/obophenotype/uberon/issues/124" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012131 ; owl:annotatedTarget "Endochondral bone located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012131 ; owl:annotatedTarget "the FMA term is under 'general anatomical term'." . [] oboInOwl:hasDbXref "FMA:77232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012131 ; owl:annotatedTarget "os centrale" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012131 ; owl:annotatedTarget "centralia" . [] oboInOwl:notes "may be revised" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012139 ; owl:annotatedTarget obo:UBERON_0002529 . _:genid152038 oboInOwl:hasDbXref "PHENOSCAPE:ni", "https://github.com/obophenotype/uberon/issues/131" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012140 ; owl:annotatedTarget "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007831 . (obo:UBERON_0012140 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] ) . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012141 ; owl:annotatedTarget "A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region." . ( ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002102 ; owl:annotatedTarget obo:CL_0000788 . _:genid152050 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012142 ; owl:annotatedTarget "A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004288 . _:genid152057 oboInOwl:hasDbXref "PHENOSCAPE:ni" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012150 ; owl:annotatedTarget "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001130 . [] oboInOwl:hasDbXref "PHENOSCAPE:ni" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012150 ; owl:annotatedTarget "digitopodium" . _:genid152059 oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012150 ; owl:annotatedTarget "skeleton of digits" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002102 ; owl:annotatedTarget "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012151 ; owl:annotatedTarget _:genid154205 . [] oboInOwl:hasDbXref "PHENOSCAPE:ni", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012151 ; owl:annotatedTarget "A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton." . (obo:UBERON_0012150 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) . ( ) . _:genid152073 oboInOwl:hasDbXref "PHENOSCAPE:ni", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012152 ; owl:annotatedTarget "A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001737 . (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001567 ] ) . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Buccal_fat_pad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012167 ; owl:annotatedTarget "The Buccal fat pad is one of several encapsulated fat masses in the cheek. It is a deep fat pad located on either side of the face between the buccinator muscle and several more superficial muscles. It should not be confused with the malar fat pad, which is directly below the skin of the cheek. It should also not be confused with jowl fat pads. It is implicated in the formation of hollow cheeks and the nasolabial fold, but not in the formation of jowls." . _:genid152079 oboInOwl:hasDbXref "FMA:59799" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012167 ; owl:annotatedTarget "Bichat's fat pad" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001740 . [] oboInOwl:hasDbXref "Wikipedia:Cord_blood" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012168 ; owl:annotatedTarget "Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." . [] oboInOwl:hasDbXref "BTO:0004053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012168 ; owl:annotatedTarget "cord blood" . [] oboInOwl:hasDbXref "MESH:A12.207.152.200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012168 ; owl:annotatedTarget "fetal blood" . [] oboInOwl:hasDbXref "MESH:A12.207.152.200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012168 ; owl:annotatedTarget "umbilical cord blood" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012172 ; owl:annotatedTarget "A primordium that has the potential to develop into a stomach." . [] oboInOwl:source "ncithesaurus:Stomach_Primordium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012172 ; owl:annotatedTarget "UMLS:C1514976" . [] oboInOwl:hasDbXref "EFO:0002580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012172 ; owl:annotatedTarget "stomach endoderm" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget obo:UBERON_0001714 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget _:genid154239 . _:genid152099 oboInOwl:source "cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget _:genid154241 ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22100291" . [] oboInOwl:hasDbXref "EMAPA:16794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget "facio-acoustic ganglion complex VII-VIII" . _:genid152101 oboInOwl:hasDbXref "VHOG:0000715" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget "facio-acoustic VII-VIII ganglion complex" ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0001684 . [] oboInOwl:hasDbXref "EMAPA:16794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012175 ; owl:annotatedTarget "facio-acoustic ganglion complex" . _:genid152103 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0008974 _:genid152105 ) ; owl:onProperty obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0002397 . _:genid152105 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001458, obo:UBERON_0002097 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012177 ; owl:annotatedTarget obo:UBERON_0002419 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012177 ; owl:annotatedTarget "An apocrine gland that is part of a skin of body." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002103 ; owl:annotatedTarget obo:CL_0000981 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012180 ; owl:annotatedTarget "A zone of skin that is part of a craniocervical region." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012180 ; owl:annotatedTarget "EMAPA:37276" . [] oboInOwl:source "ncithesaurus:Skin_of_the_Scalp_and_Neck" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012180 ; owl:annotatedTarget "UMLS:C1522650" . _:genid152116 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001638 _:genid152118 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 . _:genid152118 a owl:Restriction ; owl:onProperty obo:RO_0002179, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0001103, obo:UBERON_0009506 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002103 ; owl:annotatedTarget "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." . _:genid152120 oboInOwl:hasDbXref "ncithesaurus:Phrenic_Vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012193 ; owl:annotatedTarget "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001630 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012193 ; owl:annotatedTarget "EMAPA:37180" . [] oboInOwl:source "ncithesaurus:Phrenic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012193 ; owl:annotatedTarget "UMLS:C1709532" . [] oboInOwl:hasDbXref "Wikipedia:Intercostal_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012197 ; owl:annotatedTarget "The intercostal veins are a group of veins which drain the area between the ribs." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012198 ; owl:annotatedTarget "A space in the rib cage between two successive ribs." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget obo:UBERON_0007644 . [] oboInOwl:hasDbXref "Wikipedia:Intercostal_lymph_nodes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget "The intercostal lymph nodes (intercostal glands ) occupy the posterior parts of the intercostal spaces, in relation to the intercostal vessels. They receive the deep lymphatics from the postero-lateral aspect of the chest; some of these vessels are interrupted by small lateral intercostal glands." . [] oboInOwl:source "ncithesaurus:Intercostal_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget "UMLS:C0229761" . [] oboInOwl:hasDbXref "FMA:5932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget "intercostal node" . [] oboInOwl:hasDbXref "Wikipedia:Intercostal_lymph_nodes" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget "nodi lymphoidei intercostales" . [] oboInOwl:hasDbXref "FMA:5932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012236 ; owl:annotatedTarget "nodus intercostale" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0012239 ; owl:annotatedTarget _:genid154284 . _:genid152146 oboInOwl:hasDbXref "MP:MP" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012239 ; owl:annotatedTarget "Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0011322 . [] oboInOwl:hasDbXref "EMAPA:28679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012239 ; owl:annotatedTarget "blood vessels of bladder" . [] oboInOwl:hasDbXref "EMAPA:28679" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012239 ; owl:annotatedTarget "blood vessel of bladder" . [] oboInOwl:hasDbXref "MP:MP", "Wikipedia:Urinary_meatus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "External opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia[MP]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "EMAPA:37977" . _:genid152159 oboInOwl:hasDbXref "FMA:19650" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "external meatus of urethra" ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0001647 . [] oboInOwl:hasDbXref "FMA:19650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "external urethral orifice" . _:genid152161 oboInOwl:hasDbXref "FMA:19650" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "external urethral ostium" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0006661 . [] oboInOwl:hasDbXref "FMA:19650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "external urinary meatus" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "meatus urinarius" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "orificium urethrae externum" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "orificium urethræ externum" . [] oboInOwl:hasDbXref "FMA:19650" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012240 ; owl:annotatedTarget "urethral meatus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002104 ; owl:annotatedTarget obo:CL_0000981 . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:External_urethral_orifice_(male)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "A urethral meatus that is part of a male urethra[Automatically generated definition]." . [] oboInOwl:source "Wikipedia:External_urethral_orifice_(male)" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "The external urethral orifice is the external opening or meatus of the urethra, normally placed at the tip of glans penis; it presents as a vertical slit, possibly bounded on either side by two small labia-like projections, In some cases the slit may be more rounded. This occurs naturally in some males and may also be a side effect of excess skin removal during circumcision. Congenital misplacement of the urethral orifice is called hypospadias when it is located in the underside (ventral aspect) of the penis, and epispadias when located in the dorsum (upper aspect). Improper shaping of the meatus can result in meatal stenosis." . [] oboInOwl:hasDbXref "FMA:85265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "external orifice of male urethra" . [] oboInOwl:hasDbXref "FMA:85265" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "external urethral orifice (male)" . [] oboInOwl:hasDbXref "MA:0002642" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "male urethra ostium" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "ostium urethrae externum (urethra masculina)" . [] oboInOwl:hasDbXref "EMAPA:36434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "urethral meatus of penile urethra" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002104 ; owl:annotatedTarget "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." . [] oboInOwl:hasDbXref "EMAPA:36434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "distal urethral opening of male" . [] oboInOwl:hasDbXref "EMAPA:36434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012241 ; owl:annotatedTarget "urethral opening of penile urethra" . _:genid152188 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0010390, obo:UBERON_0010946 . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011782" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "The usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone." . [] oboInOwl:hasDbXref "FMA:85263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "internal meatus of urethra" . [] oboInOwl:hasDbXref "FMA:85263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "internal urethral orifice of urinary bladder" . [] oboInOwl:hasDbXref "FMA:85263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "internal urethral ostium" . [] oboInOwl:hasDbXref "MP:0011782" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "orificium urethrae internum" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "ostium orificium internum" . [] oboInOwl:hasDbXref "Wikipedia:Internal_urethral_orifice" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "ostium urethrae internum" . [] oboInOwl:hasDbXref "FMA:85263" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "vesicourethral orifice" . [] oboInOwl:hasDbXref "MP:0011782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "internal urethral ostium" . [] oboInOwl:hasDbXref "MP:0011782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012242 ; owl:annotatedTarget "internal urinary meatus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22130175" . (obo:UBERON_0002365 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) . ( ) . _:genid152205 oboInOwl:hasDbXref "http://www.thefreedictionary.com/cervical+glands" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012247 ; owl:annotatedTarget "Mucus-secreting glands in the mucosa of the uterine cervix." ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001681 . [] oboInOwl:source "ncithesaurus:Cervical_Gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012247 ; owl:annotatedTarget "UMLS:C2724437" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012247 ; owl:annotatedTarget "glandulae cervicales" . [] oboInOwl:hasDbXref "BTO:0000411" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012248 ; owl:annotatedTarget "Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing." . (obo:UBERON_0000064 [ a owl:Restriction ; owl:onProperty obo:BSPO_0001108 ; owl:someValuesFrom obo:UBERON_0000002 ] ) . ( ) . [] oboInOwl:source "BTO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget _:genid154361 . [] oboInOwl:hasDbXref "BTO:0001850", "Wikipedia:Vaginal_portion_of_cervix" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "distinction between two FMA classes not clear - we merge them here" . _:genid152222 oboInOwl:source "ncithesaurus:Ectocervix" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "UMLS:C0227829" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008229 . [] oboInOwl:hasDbXref "BTO:0001850", "FMA:86484" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "ectocervix" . [] oboInOwl:hasDbXref "Wikipedia:Vaginal_portion_of_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "portio vaginalis" . [] oboInOwl:hasDbXref "BTO:0001850" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "portio vaginalis cervicis" . [] oboInOwl:hasDbXref "CALOHA:TS-1098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "uterine ectocervix" . _:genid152227 oboInOwl:hasDbXref "FMA:77056" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "vaginal part of cervix" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . [] oboInOwl:hasDbXref "BTO:0001850" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012249 ; owl:annotatedTarget "exocervix" . _:genid152229 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0006799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005256 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002105 ; owl:annotatedTarget obo:CL_0000979 . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012250 ; owl:annotatedTarget "A glandular epithelium that is part of a uterine cervix." . _:genid152234 oboInOwl:source "http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0012250 ; owl:annotatedTarget "The 'glandular' or columnar epithelium of the cervix is located cephalad to the squamocolumnar junction. It covers a variable amount of the ectocervix and lines the endocervical canal. It is comprised of a single layer of mucin-secreting cells. The epithelium is thrown into longitudinal folds and invaginations that make up the so-called endocervical glands (they are not true glands). These infolding crypts and channels make the cytologic and colposcopic detection of neoplasia less reliable and more problematic. The complex architecture of the endocervical glands gives the columnar epithelium a papillary appearance through the colposcope and a grainy appearance upon gross visual inspection. The single cell layer allows the coloration of the underlying vasculature to be seen more easily. Therefore, the columnar epithelium appears more red in comparison with the more opaque squamous epithelium." ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0012198 . [] oboInOwl:source "ncithesaurus:Cervix_Columnar_Epithelium" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012250 ; owl:annotatedTarget "UMLS:C1707350" . _:genid152236 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012249 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . ( ) . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002105 ; owl:annotatedTarget "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012251 ; owl:annotatedTarget "An epithelium that is part of a ectocervix." . _:genid152241 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000458 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006210 . ( ) . [] oboInOwl:hasDbXref "ncithesaurus:Endocervical_Glandular_Epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012252 ; owl:annotatedTarget "The glandular epithelium that lines the endocervix." . (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0006922 ] _:genid152252 ) . ( _:genid152252 ) . _:genid152252 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0008713, obo:UBERON_0012250 . _:genid152254 oboInOwl:hasDbXref "http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012253 ; owl:annotatedTarget "Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . _:genid152257 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001516, obo:UBERON_0008713 . _:genid152259 oboInOwl:hasDbXref "Wikipedia:Abdominal_aorta#Branches", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012254 ; owl:annotatedTarget "An artery that originates from the abdominal aorta." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0010963 . [] oboInOwl:hasDbXref "Wikipedia:Columnar_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012274 ; owl:annotatedTarget "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]." . _:genid152262 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 _:genid152264 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003897 . _:genid152264 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000926, obo:UBERON_0010963 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012275 ; owl:annotatedTarget "Epithelium that derives from the mesoderm. [Automatically generated definition]." . (obo:UBERON_0006799 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004811 ] ) . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012276 ; owl:annotatedTarget obo:UBERON_0007592 . [] oboInOwl:hasDbXref "FMA:86488" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012276 ; owl:annotatedTarget "glandular part of endometrium" . [] oboInOwl:hasDbXref "Wikipedia:Nasal_glands" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012278 ; owl:annotatedTarget "The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012278 ; owl:annotatedTarget "EMAPA:37871" . _:genid152281 oboInOwl:source "ncithesaurus:Nose_Nasal_Cavity_Nasal_Gland_MMHCC" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012278 ; owl:annotatedTarget "UMLS:C1522269" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008895 . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012278 ; owl:annotatedTarget "glandula nasalis" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012278 ; owl:annotatedTarget "glandulae nasales" . [] oboInOwl:hasDbXref "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012282 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the mammary gland." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012282 ; owl:annotatedTarget "EMAPA:37901" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002106 ; owl:annotatedTarget obo:CL_0002105 . [] oboInOwl:hasDbXref "MP:0008905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012283 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the femur." . [] oboInOwl:hasDbXref "MP:0008905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012283 ; owl:annotatedTarget "femoral fat depot" . (obo:UBERON_0001447 [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0001451 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0010737 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22150211" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002106 ; owl:annotatedTarget "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." . [] oboInOwl:hasDbXref "UBERON:skansa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012288 ; owl:annotatedTarget "A tarsal bone that is formed from the fusion of the central and 4th tarsal bones." . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012288 ; owl:annotatedTarget "os centroquartale" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012288 ; owl:annotatedTarget "os naviculocuboideum" . [] oboInOwl:hasDbXref "UBERON:skansa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012289 ; owl:annotatedTarget "A tarsal bone that is formed from the fusion of the 2nd and 3rd tarsal bones." . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012289 ; owl:annotatedTarget "os cuneiforme intermediolaterale" . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012289 ; owl:annotatedTarget "os tarsale II et III" . [] oboInOwl:hasDbXref "UBERON:skansa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012290 ; owl:annotatedTarget "A carpal bone that is formed from the fusion of the 2nd and 3rd distal carpal bones." . [] oboInOwl:hasDbXref "Wikipedia:Malleolus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "Malleolus is the name for the bony prominence on each side of the ankle." . [] oboInOwl:hasScope "NCBITaxon:9895" ; oboInOwl:seeAlso "UBERON:0004410" ; oboInOwl:source "UBERON:skansa" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "In bovids, the distal end of the fibula is present only as the lateral malleolus, a separate bone that articulates with the lateral side of the distal tibia." . [] oboInOwl:hasDbXref "FMA:35502" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "lateral malleolus" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "EMAPA:37893" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "malleolar bone" . [] oboInOwl:hasSynonymType core:SENSU ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "malleolar bone of ankle" . [] oboInOwl:hasDbXref "Wikipedia:Malleolus#Lateral_malleolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "distal extremity of fibula" . [] oboInOwl:hasDbXref "Wikipedia:Malleolus#Lateral_malleolus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012291 ; owl:annotatedTarget "external malleolus of fibula" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012292 ; owl:annotatedTarget _:genid154476 . [] oboInOwl:hasDbXref "MP:0011836", "MP:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012292 ; owl:annotatedTarget "One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly." . [] oboInOwl:hasDbXref "EHDAA2:0004009" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0012292 ; owl:annotatedTarget "cloacal fold" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012299 ; owl:annotatedTarget "A mucosa that is part of a urethra." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012299 ; owl:annotatedTarget "EMAPA:37912" . [] oboInOwl:hasDbXref "FMA:76904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012299 ; owl:annotatedTarget "mucous membrane of urethra" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012299 ; owl:annotatedTarget "tunica mucosa urethrae" . [] oboInOwl:hasDbXref "FMA:76904" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012299 ; owl:annotatedTarget "urethral mucosa" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012313 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012313 ; owl:annotatedTarget _:genid154491 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012313 ; owl:annotatedTarget _:genid154493 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012313 ; owl:annotatedTarget _:genid154495 . [] oboInOwl:hasDbXref "EMAPA:16389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012313 ; owl:annotatedTarget "ectoderm of maxillary component" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002107 ; owl:annotatedTarget obo:CL_0002105 . [] oboInOwl:hasDbXref "http://www.indiana.edu/~anat550/hnanim/face/face.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012314 ; owl:annotatedTarget "One of five swellings formed during the development of the face." . _:genid152354 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000996, obo:UBERON_0003089 . [] oboInOwl:hasDbXref "MGI:anna", "MGI:csmith", "MP:0001142" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "The median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice." . [] oboInOwl:hasDbXref "FMA:19984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "introitus" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "EMAPA:37983" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002107 ; owl:annotatedTarget "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." . [] oboInOwl:hasDbXref "FMA:19984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "orifice of vagina" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "ostium vaginae" . [] oboInOwl:hasDbXref "MP:0001142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "vagina opening" . _:genid152363 oboInOwl:hasDbXref "FMA:19984" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "vaginal orifice" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000348 . [] oboInOwl:hasDbXref "FMA:19984" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "introitus" . [] oboInOwl:hasDbXref "MP:0001142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012317 ; owl:annotatedTarget "introitus of vagina" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget obo:UBERON_0012319 . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP]." . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "a. ethmoidalis anterior" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "arteria ethmoidalis anterior" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "anterior ethmoid artery" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "anterior meningeal arteries" . [] oboInOwl:hasDbXref "Wikipedia:Anterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012318 ; owl:annotatedTarget "anterior meningeal artery" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012319 ; owl:annotatedTarget "The posterior ethmoidal artery is an artery of the head. It is smaller than the anterior ethmoidal artery, branches off from the ophthalmic artery when it reaches the medial wall of the orbit." . [] oboInOwl:hasDbXref "Wikipedia:Posterior_ethmoidal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012319 ; owl:annotatedTarget "a. ethmoidalis posterior" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_ethmoidal_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012319 ; owl:annotatedTarget "arteria ethmoidalis posterior" . [] oboInOwl:hasDbXref "Wikipedia:Posterior_ethmoidal_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012319 ; owl:annotatedTarget "posterior ethmoidal vessel" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012320 ; owl:annotatedTarget "An artery of the neck." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012320 ; owl:annotatedTarget "EMAPA:37075" . [] oboInOwl:source "ncithesaurus:Cervical_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012320 ; owl:annotatedTarget "UMLS:C1707349" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012321 ; owl:annotatedTarget _:genid154538 . [] oboInOwl:hasDbXref "Wikipedia:Deep_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012321 ; owl:annotatedTarget "The deep cervical artery (Profunda cervicalis) is an artery of the neck." . [] oboInOwl:hasDbXref "Wikipedia:Deep_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012321 ; owl:annotatedTarget "profunda cervicalis" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "Unclear if MA class belongs here or in parent" . [] oboInOwl:hasDbXref "MA:0001936", "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "cervical artery" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "cervical transverse artery" . _:genid152396 oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "descending branch of the transverse cervical" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001490 . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "transversalis artery colli" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "transversalis colli artery" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "transverse cervical" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22240068" . [] oboInOwl:hasDbXref "Wikipedia:Transverse_cervical_artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012324 ; owl:annotatedTarget "transverse cervical vessels" . [] oboInOwl:hasDbXref "FMA:45568", "Wikipedia:Stratified_squamous_epithelium#Keratinized" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012329 ; owl:annotatedTarget "Keratinized stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesize and accumulate keratin." . [] oboInOwl:hasDbXref "FMA:45568" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012329 ; owl:annotatedTarget "epithelium stratificatum squamosum cornificatum" . _:genid152407 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001961 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001728 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001490 . [] oboInOwl:hasDbXref "ncithesaurus:Nasal-Associated_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012330 ; owl:annotatedTarget "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." . [] oboInOwl:source "ncithesaurus:Nasal-Associated_Lymphoid_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012330 ; owl:annotatedTarget "UMLS:C2698431" . [] oboInOwl:hasDbXref "Wikipedia:Mucosa-associated_lymphoid_tissue#Categorisation" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012330 ; owl:annotatedTarget "NALT" . [] oboInOwl:hasDbXref "FMA:79771" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012330 ; owl:annotatedTarget "naso-pharyngeal lymphoid tissue" . [] oboInOwl:source "MESH" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget obo:UBERON_0000211 . [] oboInOwl:hasDbXref "MESH:A02.513.170", "Wikipedia:Broad_ligament_of_the_uterus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis." . [] oboInOwl:source "ncithesaurus:Broad_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget "UMLS:C0006205" . [] oboInOwl:hasDbXref "FMA:16516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget "broad uterine ligament" . [] oboInOwl:hasDbXref "MESH:A02.513.170" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget "broad ligament" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012332 ; owl:annotatedTarget "ligamentum latum uteri" . [] oboInOwl:source "MA", "MP" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012344 ; owl:annotatedTarget obo:UBERON_0002365 . [] oboInOwl:hasDbXref "MP:0013543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012344 ; owl:annotatedTarget "Any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002108 ; owl:annotatedTarget obo:CL_0000979 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012351 ; owl:annotatedTarget "An anatomical space that is enclosed by a urachus." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012354 ; owl:annotatedTarget "The segment of the autopod that is distal to the metapodial region and consists of the digits." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002108 ; owl:annotatedTarget "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers)." . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "digiti manus" . [] oboInOwl:hasDbXref "FMA:75592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "digits of hand" . [] oboInOwl:hasDbXref "FMA:75592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "fingers including thumb" . [] oboInOwl:hasDbXref "FMA:75592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "fingers set" . [] oboInOwl:hasDbXref "FMA:75592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "set of digits of hand" . [] oboInOwl:hasDbXref "FMA:75592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012355 ; owl:annotatedTarget "set of fingers" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012356 ; owl:annotatedTarget "The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes)." . [] oboInOwl:hasDbXref "FMA:70664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012356 ; owl:annotatedTarget "digits of foot" . [] oboInOwl:hasDbXref "FMA:70664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012356 ; owl:annotatedTarget "set of toes" . [] oboInOwl:hasDbXref "FMA:70664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012356 ; owl:annotatedTarget "toes set" . [] oboInOwl:hasDbXref "FMA:70664" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012356 ; owl:annotatedTarget "toes" . (obo:UBERON_0001474 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012140 ] ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012357 ; owl:annotatedTarget "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." . [] oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012357 ; owl:annotatedTarget "digit bone" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012358 ; owl:annotatedTarget "A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton." . (obo:UBERON_0012357 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002387 ] ) . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012359 ; owl:annotatedTarget "A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton." . _:genid152485 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001694, obo:UBERON_0011595 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012360 ; owl:annotatedTarget "A bone element that is part of a jaw region." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012361 ; owl:annotatedTarget _:genid154639 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002109 ; owl:annotatedTarget obo:CL_0002101 . _:genid152494 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012367 ; owl:annotatedTarget _:genid154645 ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0002374 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012367 ; owl:annotatedTarget "A muscle layer that is part of an intestine." . [] oboInOwl:hasDbXref "FMA:15697" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012367 ; owl:annotatedTarget "intestinal muscularis propria" . [] oboInOwl:hasDbXref "FMA:15697" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012367 ; owl:annotatedTarget "muscularis externa of intestine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22290316" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002109 ; owl:annotatedTarget "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012373 ; owl:annotatedTarget "A nerve plexus that is part of a sympathetic nervous system." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012373 ; owl:annotatedTarget "EMAPA:37617" . _:genid152504 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004923 _:genid152506 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0006815 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004452 . _:genid152506 a owl:Restriction ; owl:onProperty obo:RO_0002176, obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0000042, obo:UBERON_0001435 . [] oboInOwl:hasDbXref "Wikipedia:Subserosa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012375 ; owl:annotatedTarget "A layer of tissue between the muscularis and serosa." . [] oboInOwl:source "ncithesaurus:Subserosa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012375 ; owl:annotatedTarget "UMLS:C0225334" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012377 ; owl:annotatedTarget "A muscular coat that is part of a jejunum." . [] oboInOwl:hasDbXref "FMA:14951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012377 ; owl:annotatedTarget "muscularis externa of jejunum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012377 ; owl:annotatedTarget "jejunal smooth muscle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012377 ; owl:annotatedTarget "muscularis propria of jejunum" . _:genid152520 oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012377 ; owl:annotatedTarget "smooth muscle of jejunum" ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001448 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget _:genid154677 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "A muscular coat that is part of a urinary bladder." . [] oboInOwl:source "ncithesaurus:Bladder_Muscular_Coat" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "UMLS:C1288327" . [] oboInOwl:hasDbXref "FMA:15930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "muscle layer of urinary bladder" . [] oboInOwl:hasDbXref "FMA:15930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "muscular coat of bladder" . _:genid152531 oboInOwl:hasDbXref "FMA:15930" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "muscular coat of urinary bladder" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001468 . [] oboInOwl:hasDbXref "FMA:15930" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "muscular layer of bladder" . _:genid152533 oboInOwl:hasDbXref "FMA:15930" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "muscular layer of urinary bladder" ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0001075 . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "tunica musculari vesicae" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012378 ; owl:annotatedTarget "tunica muscularis (vesica urinaria)" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012416 ; owl:annotatedTarget "EMAPA:37567" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012418 ; owl:annotatedTarget "A smooth muscle tissue that is part of a respiratory system venous blood vessel." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012418 ; owl:annotatedTarget "EMAPA:37586" . [] oboInOwl:hasDbXref "GO:0005902", "Wikipedia:Microvillus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012423 ; owl:annotatedTarget "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." . _:genid152549 oboInOwl:external_ontology "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012423 ; owl:annotatedTarget "FMA class represents an individual microvillus." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003089 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002110 ; owl:annotatedTarget obo:CL_0002101 . [] oboInOwl:source "ncithesaurus:Microvillus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012423 ; owl:annotatedTarget "UMLS:C0026049" . [] oboInOwl:hasDbXref "MESH:A11.284.180.565" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012423 ; owl:annotatedTarget "microvilli" . [] oboInOwl:hasDbXref "FMA:67296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012423 ; owl:annotatedTarget "microvillus" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/striated+border", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012425 ; owl:annotatedTarget "A microvillus layer that is striated and found in the intestine." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012425 ; owl:annotatedTarget "FMA class represents an individual microvillus" . [] oboInOwl:hasDbXref "FMA:70978" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012425 ; owl:annotatedTarget "striated border" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002110 ; owl:annotatedTarget "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget obo:UBERON_0034769 . [] oboInOwl:source "defitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget _:genid154715 . [] oboInOwl:hasDbXref "http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "Blood-forming tissue, consisting of reticular fibers and cells." . [] oboInOwl:source "ncithesaurus:Hematopoietic_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "UMLS:C0229619" . [] oboInOwl:hasDbXref "FMA:14073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "haemopoietic tissue" . [] oboInOwl:hasDbXref "FMA:14073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "hematopoietic tissue" . [] oboInOwl:hasDbXref "FMA:14073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "hemopoietic tissue" . [] oboInOwl:hasDbXref "FMA:14073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "textus haemopoieticus" . [] oboInOwl:hasDbXref "NCBITaxon:9606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0012429 ; owl:annotatedTarget "bone marrow tissue" . _:genid152573 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012430 ; owl:annotatedTarget obo:UBERON_0004923 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001008 . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_tunic_of_eyeball" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012430 ; owl:annotatedTarget "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." . [] oboInOwl:hasDbXref "FMA:58102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012430 ; owl:annotatedTarget "fibrous layer of eyeball" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_tunic_of_eyeball" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012430 ; owl:annotatedTarget "corneosclera" . _:genid152577 oboInOwl:hasDbXref "Wikipedia:Fibrous_tunic_of_eyeball" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012430 ; owl:annotatedTarget "fibrous tunic" ; owl:onProperty obo:BSPO_0000126 ; owl:someValuesFrom obo:UBERON_0001008 . _:genid152584 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012437 ; owl:annotatedTarget "An anatomical line that adjacent_to a epithelium and adjacent_to a mesenchyme." ; owl:onProperty obo:RO_0002005 ; owl:someValuesFrom obo:UBERON_0005465 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012463 ; owl:annotatedTarget _:genid154744 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012463 ; owl:annotatedTarget "An anatomical space that is enclosed by a cloaca." . [] oboInOwl:external_ontology "ZFA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0012463 ; owl:annotatedTarget "the ZFA class belongs here as it is an anatomical space. See https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/102/" . [] oboInOwl:hasDbXref "ZFA:0000330" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012463 ; owl:annotatedTarget "cloaca lumen" . [] oboInOwl:hasDbXref "ZFA:0000330" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012463 ; owl:annotatedTarget "cloacal chamber" . _:genid152597 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002150 ; owl:someValuesFrom obo:UBERON_0000162, obo:UBERON_0003350 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012464 ; owl:annotatedTarget "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22342082" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012465 ; owl:annotatedTarget "An anatomical space that is enclosed by a terminal part of digestive tract." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002111 ; owl:annotatedTarget obo:CL_0000970 . [] oboInOwl:hasDbXref "EHDAA2:0000472" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012466 ; owl:annotatedTarget "extraembryonic cavities" . _:genid152615 oboInOwl:hasDbXref "AEO:0000222" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012467 ; owl:annotatedTarget "An anatomical space with no opening to another space or to the exterior." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005884 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002111 ; owl:annotatedTarget "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . _:genid152620 oboInOwl:hasDbXref "http://species-identification.org/species.php?species_group=nasc&selected=definitie&menuentry=woordenlijst&record=Anal%20teeth", "https://orcid.org/0000-0002-6601-2165", "https://www.karger.com/Article/Pdf/142845" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012468 ; owl:annotatedTarget "Triangular calcified papillae (often five) placed radially around the anus of some Holothuriidae." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012468 ; owl:annotatedTarget "anal teeth" . _:genid152622 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012469 ; owl:annotatedTarget _:genid154777 ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget _:genid154784 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." . [] oboInOwl:hasDbXref "FMA:24139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "bones of upper limb" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "ossa membri superioris" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "pectoral complex skeleton" . [] oboInOwl:hasDbXref "FMA:24139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "set of bones of upper limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "skeleton of anterior limb/fin and girdle" . [] oboInOwl:hasDbXref "FMA:24139" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012475 ; owl:annotatedTarget "upper limb skeleton" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget _:genid154798 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle." . [] oboInOwl:hasDbXref "FMA:24140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "bones of lower limb" . [] oboInOwl:hasDbXref "FMA:24140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "lower limb skeleton" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "ossa membri inferioris" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "pelvic complex skeleton" . [] oboInOwl:hasDbXref "FMA:24140" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "set of bones of lower limb" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012476 ; owl:annotatedTarget "skeleton of posterior limb/fin and girdle" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget obo:UBERON_0005434 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget _:genid154808 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget _:genid154810 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget _:genid154812 . [] oboInOwl:hasDbXref "MP:0012723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "The posterior region of the neck, including the suboccipital region." . [] oboInOwl:hasDbXref "BTO:0000957" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "nape" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "back of neck" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "neck back" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "nucha" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "nuchal region" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "posterior cervical region" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "posterior neck region" . [] oboInOwl:hasDbXref "FMA:24189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "posterior part of neck" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012477 ; owl:annotatedTarget "regio cervicalis posterior" . _:genid152667 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012478 ; owl:annotatedTarget "A gland that is part of a cloaca." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001169 . (obo:UBERON_0000344 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002112 ; owl:annotatedTarget obo:CL_0002111 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012480 ; owl:annotatedTarget "A mucosa that is part of a cloaca [Automatically generated definition]." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012481 ; owl:annotatedTarget "An epithelium that is part of a cloaca." . [] oboInOwl:source "EMAPA:27577" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0012481 ; owl:annotatedTarget "cloacal epithelium (cle) (syn: cloacal endoderm) (TS17-TS20): the cloacal epithelium is derived from endoderm and lines the cloacal cavity. It is marked by Shh and Cdh1 and lines the cloacal lumen. The cloacal epithelium gives rise to the urogenital sinus epithelium, hindgut epithelium and the urethral plate epithelium." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002112 ; owl:annotatedTarget "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "EMAPA:27577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012481 ; owl:annotatedTarget "cloacal endoderm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012482 ; owl:annotatedTarget "A submucosa that is part of a cloaca [Automatically generated definition]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012483 ; owl:annotatedTarget "A serous membrane that is part of a cloaca [Automatically generated definition]." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012485 ; owl:annotatedTarget "cloacal villi" . (obo:UBERON_0006660 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000162 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22385337" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012486 ; owl:annotatedTarget "A muscular coat that is part of a cloaca." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012487 ; owl:annotatedTarget "A sphincter muscle that is part of a vagina." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012488 ; owl:annotatedTarget "A muscular coat that is part of a duodenum." . [] oboInOwl:hasDbXref "FMA:14944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012488 ; owl:annotatedTarget "duodenal muscularis propria" . [] oboInOwl:hasDbXref "FMA:14944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012488 ; owl:annotatedTarget "muscularis externa of duodenum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012488 ; owl:annotatedTarget "muscularis propria of duodenum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012488 ; owl:annotatedTarget "smooth muscle of duodenum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "A muscular coat that is part of a colon." . _:genid152720 oboInOwl:hasDbXref "FMA:14986" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "colonic muscularis propria" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001168 . [] oboInOwl:hasDbXref "FMA:14986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "muscular coat of colon" . [] oboInOwl:hasDbXref "FMA:14986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "muscular layer of colon" . [] oboInOwl:hasDbXref "FMA:14986" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "muscularis externa of colon" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "tunica muscularis coli" . [] oboInOwl:hasDbXref "MA:0003198" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0012489 ; owl:annotatedTarget "colon muscularis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002113 ; owl:annotatedTarget obo:CL_0002111 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012490 ; owl:annotatedTarget "A muscular coat that is part of a anal canal." . [] oboInOwl:hasDbXref "FMA:15708" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012490 ; owl:annotatedTarget "anal muscularis propria" . [] oboInOwl:hasDbXref "FMA:15708" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012490 ; owl:annotatedTarget "muscularis propria of anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "A serous membrane that is part of a fallopian tube." . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "serosa of fallopian tube" . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "serosa of oviduct" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002113 ; owl:annotatedTarget "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "serous coat of uterine tube" . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "tunica serosa (tuba uterina)" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "tunica serosa tubae uterinae" . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "uterine tubal serosa" . [] oboInOwl:hasDbXref "FMA:18316" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012499 ; owl:annotatedTarget "uterine tube serosa" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "An adventitia that is part of a esophagus." . [] oboInOwl:hasDbXref "FMA:63006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "adventitia of oesophagus" . [] oboInOwl:hasDbXref "FMA:63006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "adventitious layer of esophagus" . [] oboInOwl:hasDbXref "FMA:63006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "esophageal adventitia" . [] oboInOwl:hasDbXref "FMA:63006" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "esophagus adventitia" . _:genid152754 oboInOwl:hasDbXref "FMA:63006" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "tunica adventitia (esophagus)" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001678 . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012504 ; owl:annotatedTarget "tunica adventitia oesophageae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012615 ; owl:annotatedTarget "A smooth muscle tissue that is part of a umbilical cord." . _:genid152763 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0000945, obo:UBERON_0003386 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012650 ; owl:annotatedTarget "An anatomical junction that connects a stomach and connects a duodenum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0012651 ; owl:annotatedTarget "A mucosa that is part of a gastroduodenal junction." . [] oboInOwl:hasDbXref "BTO:0005415" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0012651 ; owl:annotatedTarget "gastroduodenal mucosa" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013069 ; owl:annotatedTarget "A depression on the ventral side of the femur, at the knee joint, between the condyles." . [] oboInOwl:hasDbXref "FMA:22525" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013069 ; owl:annotatedTarget "popliteal fossa" . [] oboInOwl:hasDbXref "Wikipedia:Popliteal_fossa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013069 ; owl:annotatedTarget "knee pit" . [] oboInOwl:hasDbXref "Wikipedia:Sulcus_(neuroanatomy)", "https://github.com/obophenotype/uberon/issues/315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals." . [] oboInOwl:source "http://neurolex.org/wiki/Cumbo_terms" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "Indentation on the surface of the brain or spinal cord that forms a recognizable landmark, e.g., central sulcus, sulcus limitans (CUMBO)" . [] oboInOwl:hasDbXref "HBA:9352" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "sulci & spaces" . [] oboInOwl:hasDbXref "NLX:144078" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "sulcus" . [] oboInOwl:hasDbXref "DHBA:10610" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "cerebral sulci" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002114 ; owl:annotatedTarget obo:CL_0000970 . [] oboInOwl:hasDbXref "Wikipedia:Sulcus_(neuroanatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "fissure of brain" . [] oboInOwl:hasDbXref "NeuroNames:1208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "cerebral sulci" . [] oboInOwl:hasDbXref "NeuroNames:1208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013118 ; owl:annotatedTarget "cerebral sulcus" . [] oboInOwl:hasDbXref "FMA:32888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013121 ; owl:annotatedTarget "basal epiphysis of phalanx of foot" . [] oboInOwl:hasDbXref "FMA:32888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013121 ; owl:annotatedTarget "base of phalanx of foot" . [] oboInOwl:hasDbXref "FMA:32888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013121 ; owl:annotatedTarget "basis phalangis (pedis)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22443779" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002114 ; owl:annotatedTarget "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013121 ; owl:annotatedTarget "basis phalangis pedis" . [] oboInOwl:hasDbXref "FMA:32888" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013121 ; owl:annotatedTarget "proximal epiphysis of phalanx of toe" . [] oboInOwl:hasDbXref "FMA:32890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "caput phalangis (pedis)" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "caput phalangis pedis" . _:genid152808 oboInOwl:hasDbXref "FMA:32890" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "distal end of phalanx of foot" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001137 . [] oboInOwl:hasDbXref "FMA:32890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "distal epiphysis of phalanx of toe" . [] oboInOwl:hasDbXref "FMA:32890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "head of phalanx of foot" . [] oboInOwl:hasDbXref "FMA:32890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013122 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of toe" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013124 ; owl:annotatedTarget "A posterior cardinal vein that is in_the_left_side_of a multicellular organism." . _:genid152817 oboInOwl:hasDbXref "FMA:70316" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013124 ; owl:annotatedTarget "left postcardinal vein" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000076 . [] oboInOwl:hasDbXref "EHDAA2:0001486" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013124 ; owl:annotatedTarget "posterior cardinal vein left" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013126 ; owl:annotatedTarget "A vein that is part of a abdomen." . [] oboInOwl:hasDbXref "Wikipedia:Interdental_plate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013135 ; owl:annotatedTarget "The interdental plate refers to the bone-filled mesial-distal region between the teeth." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0013135 ; owl:annotatedTarget "In paleobiology, the presence or absence of the interdental plate can determine the place of an animal in the evolutionary scale, and paleontologists use the interdental plate when trying to classify a new specimen. Thecodont reptiles and theropod dinosaur fossils have an interdental plate, whereas acrodont reptiles such as Sphenodontia do not.[3] Its presence in Archaeopteryx, an extinct avian, resulted in the proposal of the dinosaur-bird connection" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013136 ; owl:annotatedTarget _:genid154996 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013136 ; owl:annotatedTarget "A vein that drains a lip." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013136 ; owl:annotatedTarget "lip vein" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013136 ; owl:annotatedTarget "vena labialis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013139 ; owl:annotatedTarget "A nonskeletal ligament that is part of a liver." . [] oboInOwl:source "ncithesaurus:Liver_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013139 ; owl:annotatedTarget "UMLS:C0230238" . [] oboInOwl:hasDbXref "FMA:15820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013139 ; owl:annotatedTarget "hepatic ligament" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002115 ; owl:annotatedTarget obo:CL_0002114 . [] oboInOwl:hasDbXref "ncithesaurus:Systemic_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013140 ; owl:annotatedTarget "Any vein within the general circulation that transports blood back to the right atrium of the heart." . [] oboInOwl:source "ncithesaurus:Systemic_Vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013140 ; owl:annotatedTarget "UMLS:C0447117" . [] oboInOwl:hasDbXref "FMA:66644" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013140 ; owl:annotatedTarget "systemic venous tree organ part" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013142 ; owl:annotatedTarget obo:UBERON_0001551 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013142 ; owl:annotatedTarget _:genid155021 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002115 ; owl:annotatedTarget "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013142 ; owl:annotatedTarget "A vein that drains the soleus." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013142 ; owl:annotatedTarget "vena solealis" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013143 ; owl:annotatedTarget obo:UBERON_0001551 . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013143 ; owl:annotatedTarget _:genid155030 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013143 ; owl:annotatedTarget "A vein that drains the gastrocnemius." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013143 ; owl:annotatedTarget "vena gastrocnemii" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013147 ; owl:annotatedTarget _:genid155034 . [] oboInOwl:hasDbXref "EHDAA2:0001102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013147 ; owl:annotatedTarget "mesencephalic vesicle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013148 ; owl:annotatedTarget _:genid155037 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013148 ; owl:annotatedTarget _:genid155039 . [] oboInOwl:hasDbXref "EHDAA2:0001103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013148 ; owl:annotatedTarget "midbrain vesicle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013149 ; owl:annotatedTarget _:genid155042 . [] oboInOwl:hasDbXref "EHDAA2:0000101" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013149 ; owl:annotatedTarget "rhombencephalic vesicle" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013150 ; owl:annotatedTarget obo:UBERON_0010064 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013150 ; owl:annotatedTarget _:genid155047 . [] oboInOwl:hasDbXref "ncithesaurus:Choroidal_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013151 ; owl:annotatedTarget "One of two arteries (anterior and posterior choroidal artery) that supply blood to the choroid plexus, optic tract, hippocampus, globus pallidus, and other various brain regions." . [] oboInOwl:source "ncithesaurus:Choroidal_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013151 ; owl:annotatedTarget "UMLS:C0226164" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget _:genid155057 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget _:genid155059 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget _:genid155061 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget _:genid155063 . [] oboInOwl:hasDbXref "EMAPA:16384" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013156 ; owl:annotatedTarget "endoderm of mandibular component" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013158 ; owl:annotatedTarget "A gland that is part of a foregut-midgut junction." . [] oboInOwl:hasDbXref "EMAPA:17065" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013158 ; owl:annotatedTarget "gland of foregut-midgut junction" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "PMID:22560242" . [] oboInOwl:hasDbXref "VHOG:0000913" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013159 ; owl:annotatedTarget "mantle layer epithalamus" . [] oboInOwl:hasDbXref "VHOG:0000884" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013160 ; owl:annotatedTarget "ventricular layer epithalamus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002116 ; owl:annotatedTarget obo:CL_0002114 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013161 ; owl:annotatedTarget _:genid155087 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013161 ; owl:annotatedTarget "A telencephalic ventricle that is in_the_left_side_of a telencephalon." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002116 ; owl:annotatedTarget "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013162 ; owl:annotatedTarget _:genid155094 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013162 ; owl:annotatedTarget "A telencephalic ventricle that is in_the_right_side_of a telencephalon." . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013164 ; owl:annotatedTarget "A molar or premolar." . [] oboInOwl:hasDbXref "http://www.termwiki.com/EN:postcanine_teeth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013164 ; owl:annotatedTarget "postcanine tooth" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013164 ; owl:annotatedTarget "cheek tooth" . [] oboInOwl:hasDbXref "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013164 ; owl:annotatedTarget "molariform" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013167 ; owl:annotatedTarget obo:UBERON_0001730 . [] oboInOwl:hasDbXref "Wikipedia:Cricopharyngeal_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013167 ; owl:annotatedTarget "Laryngeal ligament that connects the cricoid cartilage to the pharynx[WP,modified]." . [] oboInOwl:hasDbXref "Wikipedia:Cricopharyngeal_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013167 ; owl:annotatedTarget "ligamentum cricopharyngeum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013168 ; owl:annotatedTarget obo:UBERON_0006325 . [] oboInOwl:hasDbXref "Wikipedia:Thyroepiglottic_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013168 ; owl:annotatedTarget "Laryngeal ligament that connects the epiglottis to the thyroid cartilage[WP,modified]." . [] oboInOwl:source "ncithesaurus:Thyroepiglottic_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013168 ; owl:annotatedTarget "UMLS:C0225514" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013168 ; owl:annotatedTarget "ligamentum thyroepiglotticum" . [] oboInOwl:hasDbXref "FMA:55230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013168 ; owl:annotatedTarget "thyroepiglottic ligament" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013170 ; owl:annotatedTarget obo:UBERON_0001730 . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013170 ; owl:annotatedTarget "Laryngeal ligament that connects the cricoid and arytenoid cartilages[WP,modified]." . [] oboInOwl:hasDbXref "FMA:55261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013170 ; owl:annotatedTarget "crico-arytenoid ligament" . [] oboInOwl:hasDbXref "Wikipedia:Cricoarytenoid_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013170 ; owl:annotatedTarget "ligamentum cricoaryteneoideum" . [] oboInOwl:hasDbXref "MURDOCH:483", "Wikipedia:Cricothyroid_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013171 ; owl:annotatedTarget "This attaches the caudal border of the thyroid cartilage to the ventral arch of the cricoid cartilage. Its sheetlike ventral portion is sometimes referred to as the cricothyroid membrane. Being elastic, it 'balances' movement at the hinge-like cricothyroid joint and determines the resting position of the larynx when the muscles are relaxed[MURDOCH]. The cricothyroid ligament is the larger part of the laryngeal membrane, continuing inferiorly as a median or anterior part and twin lateral ligaments. The median cricothyroid ligament is a flat band of white tissue joining the cricoid and thyroid cartilages, while the lateral cricothyroid ligament is also known as the cricothyroid membrane (also called conus elasticus)." . [] oboInOwl:source "ncithesaurus:Cricothyroid_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013171 ; owl:annotatedTarget "UMLS:C0225542" . [] oboInOwl:hasDbXref "Wikipedia:Cricothyroid_ligament" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013171 ; owl:annotatedTarget "ligamentum cricothyreoideum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002117 ; owl:annotatedTarget obo:CL_0000972 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013172 ; owl:annotatedTarget obo:UBERON_0001730 . [] oboInOwl:hasDbXref "MURDOCH:486", "Wikipedia:Cricotracheal_ligament" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013172 ; owl:annotatedTarget "The cricotracheal ligament connects the cricoid cartilage with the first ring of the trachea[WP]. The caudal border of the cricoid cartilage is joined to the first ring of the trachea by this ligament. It is an extrinsic laryngeal ligament. It resembles the fibrous membrane which connects the cartilaginous rings of the trachea to each other." . [] oboInOwl:source "ncithesaurus:Cricotracheal_Ligament" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013172 ; owl:annotatedTarget "UMLS:C0225543" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002117 ; owl:annotatedTarget "A class switched memory B cell that lacks IgG on the cell surface." . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013191 ; owl:annotatedTarget "The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013191 ; owl:annotatedTarget "EMAPA:37927" . [] oboInOwl:source "ncithesaurus:Ovarian_Cortex" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013191 ; owl:annotatedTarget "UMLS:C0227878" . [] oboInOwl:hasDbXref "FMA:18613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013191 ; owl:annotatedTarget "cortex of ovary" . [] oboInOwl:hasDbXref "FMA:18613" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013191 ; owl:annotatedTarget "cortex ovarii (zona parenchymatosa)" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "Highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles." . [] oboInOwl:source "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000010 ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "composed of loose connective tissue that contains blood vessels, lymph vessels and nerves" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "EMAPA:37928" . [] oboInOwl:source "ncithesaurus:Ovarian_Medulla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "UMLS:C0227879" . [] oboInOwl:hasDbXref "FMA:18616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "medulla of ovary" . [] oboInOwl:hasDbXref "FMA:18616" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "medulla ovarii (zona vasculosa)" . [] oboInOwl:hasDbXref "Wikipedia:Medulla_of_ovary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013192 ; owl:annotatedTarget "zona vasculosa of Waldeyer" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Reaxys:3587154" . [] oboInOwl:hasDbXref "Wikipedia:Gland_of_Moll" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "Glands of Moll, also known as ciliary glands, are modified apocrine sweat glands that are found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the Meibomian glands within the distal eyelid margin. These glands are relatively large and tubular-shaped. The glands of Moll are named after Dutch oculist Jacob Anton Moll (1832-1914). Glands of Moll empty into the adjacent lashes. Glands of Moll and Zeis secrete lipid that adds to the superficial layer of the tear film, retarding evaporation. The glands of Moll are prone to infection and blockage of its duct with sebum and cell debris. Blockage of the gland's duct causes swelling which can manifest itself as a stye." . [] oboInOwl:hasDbXref "FMA:59159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "Moll's gland" . [] oboInOwl:hasDbXref "FMA:59159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "ciliary gland" . [] oboInOwl:hasDbXref "FMA:59159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "ciliary gland of moll" . [] oboInOwl:hasDbXref "FMA:59159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "ciliary sweat gland of eyelid" . [] oboInOwl:hasDbXref "FMA:59159" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013228 ; owl:annotatedTarget "gland of Moll" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013229 ; owl:annotatedTarget "Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland)." . _:genid153011 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001711 ] ) ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0000375 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013231 ; owl:annotatedTarget "Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013232 ; owl:annotatedTarget "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." . [] oboInOwl:hasDbXref "BSPO:0000068", "UBERONREF:0000006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013235 ; owl:annotatedTarget "A major organism subdivisionthat is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane." . [] oboInOwl:hasDbXref "FMA:259204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013235 ; owl:annotatedTarget "front of body proper" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002118 ; owl:annotatedTarget obo:CL_0002117 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013239 ; owl:annotatedTarget _:genid155208 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013239 ; owl:annotatedTarget "A future glans that is part of a male genital tubercle." . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013240 ; owl:annotatedTarget _:genid155215 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002118 ; owl:annotatedTarget "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013240 ; owl:annotatedTarget "A future glans that is part of a female genital tubercle." . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013241 ; owl:annotatedTarget _:genid155218 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013241 ; owl:annotatedTarget "The precursor of the urethra." . [] oboInOwl:source "Wikipedia:Urethral_groove" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0013241 ; owl:annotatedTarget "In humans, the urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. It typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week" . [] oboInOwl:hasDbXref "Wikipedia:Urethral_groove" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013241 ; owl:annotatedTarget "sulcus urethralis primarius" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013247 ; owl:annotatedTarget _:genid155229 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013247 ; owl:annotatedTarget _:genid155231 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013247 ; owl:annotatedTarget "An epithelial tube that develops from a Mullerian duct in a male. Later degenerates." . [] oboInOwl:hasDbXref "EMAPA:29161" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013247 ; owl:annotatedTarget "degenerating mesonephric portion of male paramesonephric duct" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Body_of_fibula" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "A diaphysis that is part of a fibula[Automatically generated definition]." . [] oboInOwl:source "Wikipedia:Body_of_fibula" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "The body of fibula presents four borders - the antero-lateral, the antero-medial, the postero-lateral, and the postero-medial; and four surfaces - anterior, posterior, medial, and lateral[Wikipedia:Body_of_fibula]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "EMAPA:37892" . [] oboInOwl:hasDbXref "FMA:33738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "body of fibula" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "corpus fibulae" . [] oboInOwl:hasDbXref "FMA:33738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "fibula diaphysis" . [] oboInOwl:hasDbXref "FMA:33738" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013279 ; owl:annotatedTarget "shaft of fibula" . [] oboInOwl:hasDbXref "OBOL:automatic", "Wikipedia:Body_of_tibia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "A diaphysis that is part of a tibia." . [] oboInOwl:source "Wikipedia:Body_of_tibia" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "The body of the tibia has three borders and three surfaces[Wikipedia:Body_of_tibia]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "EMAPA:37770" . [] oboInOwl:hasDbXref "FMA:33125" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "body of tibia" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "corpus tibiae" . [] oboInOwl:hasDbXref "FMA:33125" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "shaft of tibia" . [] oboInOwl:hasDbXref "FMA:33125" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "tibial diaphysis" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "body of the tibia" . [] oboInOwl:hasDbXref "Wikipedia:Body_of_tibia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013280 ; owl:annotatedTarget "shaft of tibia" . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget _:genid155263 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "Anatomical cavity that is the lumen of the skull and contains the brain." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "EMAPA:37497" . [] oboInOwl:source "ncithesaurus:Cranial_Cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "UMLS:C0230041" . [] oboInOwl:hasDbXref "FMA:9644", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "cavitas cranii" . [] oboInOwl:hasDbXref "Wikipedia:Cranial_cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "intracranial cavity" . [] oboInOwl:hasDbXref "Wikipedia:Cranial_cavity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013411 ; owl:annotatedTarget "intracranial space" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002119 ; owl:annotatedTarget obo:CL_0002117 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013424 ; owl:annotatedTarget _:genid155277 . [] oboInOwl:hasDbXref "Wikipedia:Lambda_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013424 ; owl:annotatedTarget "The occipital angle is rounded and corresponds with the point of meeting of the sagittal and lambdoidal sutures-a point which is termed the lambda (after the Greek letter of the same name); in the fetus this part of the skull is membranous, and is called the posterior fontanelle." . [] oboInOwl:hasDbXref "Wikipedia:Lambda_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0013424 ; owl:annotatedTarget "lambda" . [] oboInOwl:hasDbXref "Wikipedia:Lambda_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013424 ; owl:annotatedTarget "posterior fontanelle" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "AMMONIA" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002119 ; owl:annotatedTarget "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." . (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001677 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0001694 ] ) . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013455 ; owl:annotatedTarget _:genid155288 . [] oboInOwl:hasDbXref "Wikipedia:Sphenopetrosal_fissure" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013455 ; owl:annotatedTarget "The sphenopetrosal fissure (or sphenopetrosal suture) is the cranial suture between the sphenoid bone and the petrous portion of the temporal bone. It is in the middle cranial fossa." . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013455 ; owl:annotatedTarget "fissura sphenopetrosa" . [] oboInOwl:hasDbXref "FMA:75038" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013455 ; owl:annotatedTarget "sphenopetrosal fissure" . [] oboInOwl:hasDbXref "ncithesaurus:Upper_Third_of_the_Esophagus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013472 ; owl:annotatedTarget "The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type." . _:genid153112 oboInOwl:source "ncithesaurus:Upper_Third_of_the_Esophagus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013472 ; owl:annotatedTarget "UMLS:C0227187" ; owl:onProperty obo:RO_0002373 ; owl:someValuesFrom obo:UBERON_0001676 . [] oboInOwl:hasDbXref "Wikipedia:Von_Ebner's_gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013475 ; owl:annotatedTarget "A serous salivary gland which resides adjacent to the moats surrounding the circumvallate papillae in the posterior one-third of the tongue, anterior to the terminal sulcus." . [] oboInOwl:hasDbXref "PMCID:PMC2667924" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013475 ; owl:annotatedTarget "posterior deep lingual gland" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013475 ; owl:annotatedTarget "posterior lingual serous gland" . [] oboInOwl:hasDbXref "Wikipedia:Von_Ebner's_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013475 ; owl:annotatedTarget "von Ebner gland" . [] oboInOwl:hasDbXref "Wikipedia:Von_Ebner's_gland" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013475 ; owl:annotatedTarget "von Ebner's gland" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013479 ; owl:annotatedTarget "A blood vessel endothelium that is part of a lung [Automatically generated definition]." . [] oboInOwl:hasDbXref "BTO:0004128" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013479 ; owl:annotatedTarget "respiratory endothelium" . [] oboInOwl:hasDbXref "Wikipedia:Cervical_fascia", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013491 ; owl:annotatedTarget "Any fascia tissue that is part of the neck region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013493 ; owl:annotatedTarget "A fascia that is part of a abdomen." . [] oboInOwl:hasDbXref "FMA:19841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013493 ; owl:annotatedTarget "endo-abdominopelvic fascia" . [] oboInOwl:hasDbXref "FMA:19841" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013493 ; owl:annotatedTarget "fascia of abdomen" . [] oboInOwl:hasDbXref "EHDAA2:0004313" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013498 ; owl:annotatedTarget "vestibular VIII ganglion complex" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002120 ; owl:annotatedTarget obo:CL_0002118 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013501 ; owl:annotatedTarget "A sphincter muscle that is part of a cloaca." . [] oboInOwl:source "ncithesaurus:Cloacal_Sphincter" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013501 ; owl:annotatedTarget "UMLS:C1516658" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013501 ; owl:annotatedTarget "sphincter cloacae" . (obo:UBERON_0018142 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002120 ; owl:annotatedTarget "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013503 ; owl:annotatedTarget "A caudal vertebra endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013503 ; owl:annotatedTarget "coccygeal vertebra cartilage element" . [] oboInOwl:hasDbXref "EHDAA2:0000260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013503 ; owl:annotatedTarget "coccygeal vertebral cartilage condensation group" . [] oboInOwl:hasDbXref "EMAPA:18044" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013503 ; owl:annotatedTarget "tail vertebral cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013504 ; owl:annotatedTarget "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013504 ; owl:annotatedTarget "coccygeal vertebra pre-cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:18045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013504 ; owl:annotatedTarget "tail vertebral pre-cartilage condensation" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013505 ; owl:annotatedTarget "A cervical vertebra endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0000240" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013505 ; owl:annotatedTarget "cervical vertebral cartilage condensation group" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013506 ; owl:annotatedTarget "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." . _:genid153191 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011565, obo:UBERON_0013508 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013507 ; owl:annotatedTarget "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0002014" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013507 ; owl:annotatedTarget "thoracic vertebral cartilage condensation group" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Ammonia" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013508 ; owl:annotatedTarget "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." . _:genid153205 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004408, obo:UBERON_0013510 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013509 ; owl:annotatedTarget "A lumbar vertebra endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "EHDAA2:0001038" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013509 ; owl:annotatedTarget "lumbar vertebral cartilage condensation group" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002121 ; owl:annotatedTarget obo:CL_0002118 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013510 ; owl:annotatedTarget "A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013514 ; owl:annotatedTarget "The space that surrounds an organism." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002121 ; owl:annotatedTarget "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "A section through the tube or network of tubes that connects the ovaries to the outside of the body." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "FMA class may only represent the uterine portion" . [] oboInOwl:hasDbXref "FMA:18302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "subdivision of oviduct" . [] oboInOwl:hasDbXref "FMA:18302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "uterine tube zone" . [] oboInOwl:hasDbXref "FMA:18302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "zone of uterine tube" . [] oboInOwl:hasDbXref "FMA:18302" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0013515 ; owl:annotatedTarget "subdivision of fallopian tube" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013525 ; owl:annotatedTarget _:genid155421 . _:genid153239 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013525 ; owl:annotatedTarget "The anatomical space that is enclosed by a stomach." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003081 . [] oboInOwl:source "FMA:14585" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013525 ; owl:annotatedTarget "Organ cavity which is bound by the internal surface of the wall of stomach. Examples: There is only one cavity of stomach[FMA:14585]." . [] oboInOwl:hasDbXref "FMA:14585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013525 ; owl:annotatedTarget "cavity of stomach" . [] oboInOwl:hasDbXref "FMA:14585" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013525 ; owl:annotatedTarget "gastric cavity" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013526 ; owl:annotatedTarget obo:UBERON_0007473 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013526 ; owl:annotatedTarget _:genid155432 . _:genid153249 oboInOwl:source "EHDAA2" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013526 ; owl:annotatedTarget _:genid155434 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004381 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013526 ; owl:annotatedTarget "An anatomical cavity that is part of a ear vesicle." . [] oboInOwl:hasDbXref "EMAPA:25363" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013526 ; owl:annotatedTarget "lumen of otocyst" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013581 ; owl:annotatedTarget "A metapodium bone that is part of a digit 1 plus metapodial segment." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013582 ; owl:annotatedTarget "A metapodium bone that is part of a digit 2 plus metapodial segment." . _:genid153262 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006050 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004381 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013583 ; owl:annotatedTarget "A metapodial bone that is associated with digit III." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013583 ; owl:annotatedTarget "3rd metapodium bone" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013583 ; owl:annotatedTarget "metapodial bone III" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "Wikipedia:Equine_forelimb_anatomy#Metacarpal_bones" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0013583 ; owl:annotatedTarget "cannon bone" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002122 ; owl:annotatedTarget obo:CL_0002119 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013584 ; owl:annotatedTarget "A metapodium bone that is part of a digit 4 plus metapodial segment." . (obo:UBERON_0003821 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_5006052 ] ) . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013585 ; owl:annotatedTarget "A metapodium bone that is part of a digit 5 plus metapodial segment." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002122 ; owl:annotatedTarget "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-7920-5321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013586 ; owl:annotatedTarget "An element formed from the fusion of metapodium 3 and metapodium 4 (i.e. either metatarsals 3 and 4 or metacarpals 3 and 4)." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013586 ; owl:annotatedTarget "os metapodiale III et IV" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-7920-5321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013587 ; owl:annotatedTarget "An element formed from the fusion of metacarpal 3 and metacarpal 4." . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013587 ; owl:annotatedTarget "os metacarpale III et IV" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "ammonia" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-7920-5321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013588 ; owl:annotatedTarget "An element formed from the fusion of metatarsal 3 and metatarsal 4." . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013588 ; owl:annotatedTarget "os metatarsale III et IV (Ru)" . _:genid153304 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003655 _:genid153306 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 . _:genid153306 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004068, obo:UBERON_0007116 . _:genid153308 oboInOwl:hasDbXref "FMA:84206" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013616 ; owl:annotatedTarget "deciduous molar tooth" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005868 . [] oboInOwl:hasDbXref "FMA:84206" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013616 ; owl:annotatedTarget "primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84206" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013616 ; owl:annotatedTarget "temporary molar tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013617 ; owl:annotatedTarget "A primary molar tooth that is part of a upper jaw region." . [] oboInOwl:hasDbXref "FMA:84210" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013617 ; owl:annotatedTarget "upper deciduous molar tooth" . [] oboInOwl:hasDbXref "FMA:84210" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013617 ; owl:annotatedTarget "upper primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84207" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013618 ; owl:annotatedTarget "permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:84207" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013618 ; owl:annotatedTarget "secondary molar tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013619 ; owl:annotatedTarget "A secondary molar tooth that is part of a upper jaw region." . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013619 ; owl:annotatedTarget "maxillary secondary molar tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002123 ; owl:annotatedTarget obo:CL_0002119 . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013619 ; owl:annotatedTarget "upper permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:55720" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013619 ; owl:annotatedTarget "upper secondary molar tooth" . _:genid153332 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0013616 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000165 . _:genid153336 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013620 ; owl:annotatedTarget "A primary molar tooth that is part of a lower jaw region." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 . [] oboInOwl:hasDbXref "FMA:84213" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013620 ; owl:annotatedTarget "lower deciduous molar tooth" . _:genid153338 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0013618 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001710 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005867 . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002123 ; owl:annotatedTarget "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013621 ; owl:annotatedTarget "A secondary molar tooth that is part of a lower jaw region." . [] oboInOwl:hasDbXref "FMA:55721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013621 ; owl:annotatedTarget "lower permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:55721" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013621 ; owl:annotatedTarget "mandibular secondary molar tooth" . [] oboInOwl:source "NCIT" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013630 ; owl:annotatedTarget obo:UBERON_0001474 . [] oboInOwl:hasDbXref "Wikipedia:Short_bone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013630 ; owl:annotatedTarget "Short bones are designated as those bones that are as wide as they are long. Their primary function is to provide support and stability with little to no movement. They are one of five types of bones: long, short, flat, irregular and sesamoid. Examples of these bones include the tarsals in the foot and the carpals in the hand." . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013631 ; owl:annotatedTarget obo:UBERON_0010911 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013631 ; owl:annotatedTarget _:genid155534 . [] oboInOwl:hasDbXref "PSPUB:0000169", "VSAO:0000137" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013631 ; owl:annotatedTarget "Ossicle that develops within bands of dense, regular connective tissue (e.g., tendons and ligaments). Sesamoids are generally located proximate to a bony prominence, over which the dense regular connective tissue wraps, and/or a joint or articulation." . [] oboInOwl:hasDbXref "VSAO:0000137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013631 ; owl:annotatedTarget "sesamoid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013632 ; owl:annotatedTarget "A sesamoid element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "FMA:55379" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013632 ; owl:annotatedTarget "cartilago sesamoidea" . [] oboInOwl:hasDbXref "FMA:55379" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013632 ; owl:annotatedTarget "sesamoid cartilage of cricopharyngeal ligament" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013636 ; owl:annotatedTarget _:genid155549 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013636 ; owl:annotatedTarget "An epithelium that is part of a intestinal villus." . [] oboInOwl:hasDbXref "FMA:63587" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013636 ; owl:annotatedTarget "intestinal villus epithelium" . _:genid153369 oboInOwl:hasDbXref "ncithesaurus:Lateral_Lobe_of_the_Prostate" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013637 ; owl:annotatedTarget "The prostate gland lobe that is located on the lateral side of the organ." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0011607 . [] oboInOwl:hasDbXref "FMA:19577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013637 ; owl:annotatedTarget "lateral lobe of prostate" . [] oboInOwl:hasDbXref "FMA:19577" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013637 ; owl:annotatedTarget "lateral lobe of prostate gland" . [] oboInOwl:hasDbXref "MorphoBank:MorphoBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013637 ; owl:annotatedTarget "lateral ventral lobe of prostate gland" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget _:genid155562 . [] oboInOwl:hasDbXref "Wikipedia:Buccal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget "The buccal nerve (also called the long buccal nerve) is a nerve in the face. It is a branch of the mandibular nerve (which is itself a branch of the trigeminal nerve) and transmits sensory information from skin over the buccal membrane (in general, the cheek) and from the second and third molar teeth." . [] oboInOwl:hasDbXref "FMA:53066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget "buccinator nerve" . [] oboInOwl:hasDbXref "FMA:53066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget "long buccal nerve" . [] oboInOwl:hasDbXref "Wikipedia:Buccal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget "buccinator branch" . [] oboInOwl:hasDbXref "Wikipedia:Buccal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013646 ; owl:annotatedTarget "long buccal nerve" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget _:genid155573 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "A nerve that innervates the lateral pterygoid muscle." . [] oboInOwl:source "Wikipedia:Lateral_pterygoid_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "The nerve to the Pterygoideus externus frequently arises in conjunction with the buccinator nerve, but it may be given off separately from the anterior division of the mandibular nerve. It enters the deep surface of the muscle." . [] oboInOwl:hasDbXref "FMA:53107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "branch of buccal nerve to lateral pterygoid" . [] oboInOwl:hasDbXref "FMA:53107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "nerve to lateral pterygoid" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "nervus pterygoideus lateralis" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_pterygoid_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013647 ; owl:annotatedTarget "external pterygoid nerve" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013648 ; owl:annotatedTarget _:genid155585 . [] oboInOwl:hasDbXref "Wikipedia:Masseteric_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013648 ; owl:annotatedTarget "The masseteric artery is small and passes laterally through the mandibular notch to the deep surface of the masseter muscle, which it supplies. It anastomoses with the masseteric branches of the external maxillary artery and with the transverse facial artery." . [] oboInOwl:source "ncithesaurus:Masseteric_Artery" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013648 ; owl:annotatedTarget "UMLS:C0226149" . [] oboInOwl:hasDbXref "Wikipedia:Masseteric_artery" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013648 ; owl:annotatedTarget "arteria masseterica" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "azane" . _:genid153405 oboInOwl:hasDbXref "UBERON:skansa" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013649 ; owl:annotatedTarget "A tarsal bone that is formed from the fusion of the 1st and 2nd tarsal bones." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003113 . [] oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013649 ; owl:annotatedTarget "os cuneiforme mediointermedium" . _:genid153407 oboInOwl:hasDbXref "NominaAnatomicaVeterinaria:2005" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013649 ; owl:annotatedTarget "os tarsale I et II" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003277 . (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001456 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013679 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002176 ; owl:someValuesFrom obo:UBERON_0013680 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013678 ; owl:annotatedTarget "An anatomical line of the face that connects the two inner (medial) canthi of the eye. The length of this line is known as the inter canthal distance." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013679 ; owl:annotatedTarget "An inner canthus that is part of a right eye." . [] oboInOwl:hasDbXref "FMA:59319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013679 ; owl:annotatedTarget "right medial palpebral commissure" . [] oboInOwl:hasDbXref "FMA:59319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013679 ; owl:annotatedTarget "medial angle of right eye" . [] oboInOwl:hasDbXref "FMA:59319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013679 ; owl:annotatedTarget "medial canthus of right eye" . _:genid153425 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005611 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0004548 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009479 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013680 ; owl:annotatedTarget "An inner canthus that is part of a left eye." . [] oboInOwl:hasDbXref "FMA:59320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013680 ; owl:annotatedTarget "left medial palpebral commissure" . [] oboInOwl:hasDbXref "FMA:59320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013680 ; owl:annotatedTarget "medial angle of left eye" . [] oboInOwl:hasDbXref "FMA:59320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013680 ; owl:annotatedTarget "medial canthus of left eye" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013683 ; owl:annotatedTarget "A dorsal thalamus that is in_the_left_side_of a diencephalon." . [] oboInOwl:hasDbXref "FMA:258716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0013683 ; owl:annotatedTarget "left thalamus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002124 ; owl:annotatedTarget obo:CL_0000800 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013684 ; owl:annotatedTarget "A dorsal thalamus that is in_the_right_side_of a diencephalon." . [] oboInOwl:hasDbXref "FMA:258714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0013684 ; owl:annotatedTarget "right thalamus" . [] oboInOwl:hasDbXref "TAO:curator", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013685 ; owl:annotatedTarget "Anatomical space that is an opening in a bone of the skull." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:19270712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002124 ; owl:annotatedTarget "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." . [] oboInOwl:hasDbXref "Wikipedia:Foramina_of_the_skull" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013685 ; owl:annotatedTarget "foramen of skull" . [] oboInOwl:hasDbXref "FMA:53165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0013685 ; owl:annotatedTarget "cranial conduit" . [] oboInOwl:hasDbXref "Wikipedia:Foramina_of_the_skull" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013685 ; owl:annotatedTarget "foramina of the skull" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013686 ; owl:annotatedTarget obo:UBERON_0000464 . [] oboInOwl:hasDbXref "FMA:9338", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013686 ; owl:annotatedTarget "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013687 ; owl:annotatedTarget "Periosteum that is part of a skull." . [] oboInOwl:hasDbXref "FMA:76623", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013687 ; owl:annotatedTarget "periosteum externum cranii" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013688 ; owl:annotatedTarget "A germinal center that is part of a tonsil." . [] oboInOwl:source "TS-1288" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013688 ; owl:annotatedTarget "The germinal center or reaction center is the activated center of a lymphoid follicle in secondary lymphoid tissue where B-lymphocytes are stimulated by antigens and helper T cells (T-lymphocytes, helper-inducer) are stimulated to generate memory cells. Here, the germinal center of a tonsil[TS-1288]." . _:genid153469 oboInOwl:hasDbXref "CALOHA:TS-1288" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013688 ; owl:annotatedTarget "tonsil reaction center" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010172 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget _:genid155661 . [] oboInOwl:hasDbXref "Wikipedia:Buttocks", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "A zone of soft tissue located on the posterior of the lateral side of the pelvic region corresponding to the gluteal muscles." . [] oboInOwl:source "ncithesaurus:Buttock" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "UMLS:C0006497" . [] oboInOwl:hasDbXref "FMA:25245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "clunis" . [] oboInOwl:hasDbXref "FMA:25245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "gluteal part of pelvic girdle" . [] oboInOwl:hasDbXref "FMA:25245" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "gluteal region" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "regio glutealis" . [] oboInOwl:hasDbXref "Wikipedia:Buttocks" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013691 ; owl:annotatedTarget "buttocks" . [] oboInOwl:hasDbXref "CALOHA:TS-0092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013694 ; owl:annotatedTarget "Vascular endothelium found in blood vessels of the blood-brain-barrier." . [] oboInOwl:hasDbXref "CALOHA:TS-0092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013694 ; owl:annotatedTarget "cerebromicrovascular endothelium" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "Vascular endothelium found in colon blood vessels." . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colon endothelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colon endothelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colonic endothelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colonic endothelium" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colorectal endothelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-0162" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013695 ; owl:annotatedTarget "colorectal endothelium" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "Ammoniak" . [] oboInOwl:hasDbXref "CALOHA:TS-2070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013696 ; owl:annotatedTarget "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." . [] oboInOwl:hasDbXref "CALOHA:TS-2070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013696 ; owl:annotatedTarget "epithelium of tonsil" . [] oboInOwl:hasDbXref "CALOHA:TS-2070" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013696 ; owl:annotatedTarget "tonsil epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-2108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013697 ; owl:annotatedTarget "Epithelium lining the exocrine pancreas." . [] oboInOwl:hasDbXref "CALOHA:TS-2108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013697 ; owl:annotatedTarget "epithelium of exocrine pancreas" . [] oboInOwl:hasDbXref "CALOHA:TS-2108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013697 ; owl:annotatedTarget "exocrine pancreas epithelial cell" . [] oboInOwl:hasDbXref "Wikipedia:Pubic_hair" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013698 ; owl:annotatedTarget "A hair in the frontal genital area of adolescent and adult humans, located on and around the sex organs, the crotch, and sometimes at the top of the inside of the thighs, in the pubic region around the pubis bone." . [] oboInOwl:source "ncithesaurus:Pubic_Hair" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013698 ; owl:annotatedTarget "UMLS:C1305636" . [] oboInOwl:hasDbXref "FMA:54319" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013698 ; owl:annotatedTarget "pubic hair" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013699 ; owl:annotatedTarget "A strand of hair that is part of a axilla." . [] oboInOwl:hasDbXref "FMA:54253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013699 ; owl:annotatedTarget "axillary hair" . [] oboInOwl:hasDbXref "FMA:54253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013699 ; owl:annotatedTarget "hair of axilla" . [] oboInOwl:hasDbXref "HP:0003327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013700 ; owl:annotatedTarget "Musculature of the head and neck, spine, and ribs." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013701 ; owl:annotatedTarget "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013702 ; owl:annotatedTarget obo:UBERON_0000475 . [] oboInOwl:hasDbXref "AEO:0000103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013702 ; owl:annotatedTarget "The region of the organism associated with the visceral organs." . [] oboInOwl:source "FMA:231424" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013702 ; owl:annotatedTarget "Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]." . [] oboInOwl:hasDbXref "AEO:0000103" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013702 ; owl:annotatedTarget "body" . [] oboInOwl:hasDbXref "BTO:0001489" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013702 ; owl:annotatedTarget "whole body" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013703 ; owl:annotatedTarget "Anatomical projection that is part of the integumentl system." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/notochordal+canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013704 ; owl:annotatedTarget "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." . [] oboInOwl:source "ncithesaurus:Notochordal_Canal" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013704 ; owl:annotatedTarget "UMLS:C1518428" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget obo:UBERON_0003916 . [] oboInOwl:hasDbXref "Wikipedia:Fascia_of_Scarpa" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "The deep layer (fascia of Scarpa) is a layer of the anterior abdominal wall." . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "Colles' fascia" . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "Scarpa's fascia" . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "deep layer of superficial fascia of abdomen" . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "membranous layer of subcutaneous tissue of abdomen" . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "membranous layer of superficial fascia of abdomen" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "stratum membranosum telae subcutaneae abdominis" . [] oboInOwl:hasDbXref "FMA:19923" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "Colles fascia" . [] oboInOwl:hasDbXref "Wikipedia:Fascia_of_Scarpa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "Scarpa's fascia" . [] oboInOwl:hasDbXref "Wikipedia:Fascia_of_Scarpa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013705 ; owl:annotatedTarget "fascia of Scarpa" . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013718 ; owl:annotatedTarget "The dartos fascia is a fat-free layer of smooth muscular fiber outside the external spermatic fascia but below the skin. It is a continuation of Scarpa's Fascia which is a membranous layer of the subcutaneous tissue in the abdominal wall." . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013718 ; owl:annotatedTarget "dartos muscle" . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013718 ; owl:annotatedTarget "dartos tunic" . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013718 ; owl:annotatedTarget "tunica dartos" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013719 ; owl:annotatedTarget "A dartos muscle that is part of a male reproductive system." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000009 ; owl:annotatedSource obo:UBERON_0013719 ; owl:annotatedTarget "The tunica dartos acts to regulate the temperature of the testicles, which promotes spermatogenesis. It does this by expanding or contracting to wrinkle the scrotal skin. The wrinkled (rugose) appearance of the scrotum is due to this layer of fascia" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0013719 ; owl:annotatedTarget "the FMA class appears to belong here due to its synonyms." . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013719 ; owl:annotatedTarget "dartos tunic" . _:genid153573 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0013718 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000474 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002199 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013720 ; owl:annotatedTarget "A dartos muscle that is part of a female reproductive system." . [] oboInOwl:hasDbXref "Wikipedia:Dartos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013720 ; owl:annotatedTarget "dartos muliebris" . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "The entrance to the inguinal canal." . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "abdominal inguinal ring" . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "annulus inguinalis profundus" . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "internal abdominal ring" . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "internal inguinal ring" . [] oboInOwl:hasDbXref "Wikipedia:Deep_inguinal_ring" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013721 ; owl:annotatedTarget "internal ring" . [] oboInOwl:hasDbXref "http://animaldiversity.org/accounts/Latimeria_chalumnae/", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013727 ; owl:annotatedTarget "Fluid contained within the notochordal canal." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "NH3" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013748 ; owl:annotatedTarget _:genid155793 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013748 ; owl:annotatedTarget "A metaphysis that is part of a ulna." . [] oboInOwl:hasDbXref "FMA:33767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013748 ; owl:annotatedTarget "metaphysis of ulna" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013749 ; owl:annotatedTarget "A metaphysis that is part of a metaphysis." . [] oboInOwl:hasDbXref "FMA:32830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013749 ; owl:annotatedTarget "diaphyseal end of humerus" . [] oboInOwl:hasDbXref "FMA:32830" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013749 ; owl:annotatedTarget "humeral metaphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013750 ; owl:annotatedTarget "A metaphysis that is part of a tibia." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013750 ; owl:annotatedTarget "EMAPA:37772" . [] oboInOwl:hasDbXref "FMA:33135" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013750 ; owl:annotatedTarget "tibial metaphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013751 ; owl:annotatedTarget "A metaphysis that is part of a radius bone." . [] oboInOwl:hasDbXref "FMA:33789" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013751 ; owl:annotatedTarget "radial metaphysis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "A diaphysis that is part of a metacarpal bone." . [] oboInOwl:hasDbXref "FMA:33804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "body of metacarpal" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "corpus ossis metacarpi" . [] oboInOwl:hasDbXref "FMA:33804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "metacarpal bone diaphysis" . [] oboInOwl:hasDbXref "FMA:33804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "shaft of metacarpal" . [] oboInOwl:hasDbXref "FMA:33804" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013752 ; owl:annotatedTarget "shaft of metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013753 ; owl:annotatedTarget "A distal epiphysis that is part of a metacarpal bone." . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013753 ; owl:annotatedTarget "caput ossis metacarpi" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002126 ; owl:annotatedTarget obo:CL_0000799 . [] oboInOwl:hasDbXref "FMA:33798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013753 ; owl:annotatedTarget "distal end of metacarpal bone" . [] oboInOwl:hasDbXref "FMA:33798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013753 ; owl:annotatedTarget "head of metacarpal bone" . [] oboInOwl:hasDbXref "FMA:33798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013753 ; owl:annotatedTarget "lower end of metacarpal bone" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013754 ; owl:annotatedTarget "An organ component layer that is part of a integumental system." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19270712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002126 ; owl:annotatedTarget "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013755 ; owl:annotatedTarget "A blood that is part of a artery." . [] oboInOwl:hasDbXref "FMA:83066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013755 ; owl:annotatedTarget "arterial blood" . [] oboInOwl:hasDbXref "FMA:83066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013755 ; owl:annotatedTarget "blood in artery" . [] oboInOwl:hasDbXref "FMA:83066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013755 ; owl:annotatedTarget "portion of arterial blood" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013756 ; owl:annotatedTarget "A blood that is part of a vein." . [] oboInOwl:hasDbXref "FMA:83067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013756 ; owl:annotatedTarget "blood in vein" . [] oboInOwl:hasDbXref "FMA:83067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013756 ; owl:annotatedTarget "portion of venous blood" . [] oboInOwl:hasDbXref "FMA:83067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013756 ; owl:annotatedTarget "venous blood" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013757 ; owl:annotatedTarget "A blood that is part of a capillary." . [] oboInOwl:hasDbXref "FMA:263901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013757 ; owl:annotatedTarget "portion of blood in capillary" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013758 ; owl:annotatedTarget "One of two openings in the uterine cervix." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "Opening of uterine cervix into the vagina." . [] oboInOwl:source "Wikipedia:External_orifice_of_the_uterus" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "The external orifice of the uterus (or ostium of uterus, or external os) is a small, depressed, somewhat circular aperture on the rounded extremity of the vaginal portion of the cervix. Through this aperture, the cervical cavity communicates with that of the vagina. The external orifice is bounded by two lips, an anterior and a posterior. The anterior is shorter and thicker, though it projects lower than the posterior because of the slope of the cervix. Normally, both lips are in contact with the posterior vaginal wall. Prior to pregnancy, the external orifice has a rounded shape when viewed through the vaginal canal (as through a speculum). Following parturition, the orifice takes on an appearance more like a transverse slit or is 'H-shaped'[Wikipedia:External_orifice_of_the_uterus]." . [] oboInOwl:source "ncithesaurus:Ectocervical_Os" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "UMLS:C1512165" . [] oboInOwl:hasDbXref "FMA:76836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "external os of uterus" . _:genid153686 oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "ostium uteri" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001846 . [] oboInOwl:hasDbXref "Wikipedia:External_orifice_of_the_uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "external os" . [] oboInOwl:hasDbXref "Wikipedia:External_orifice_of_the_uterus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013760 ; owl:annotatedTarget "ostium of uterus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "The cavity formed by the walls of the cervix." . [] oboInOwl:hasDbXref "FMA:17746" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "lumen of cervix of uterus" . [] oboInOwl:hasDbXref "Wikipedia:Canal_of_the_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "canal of the cervix" . [] oboInOwl:hasDbXref "BTO:0002249" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "cavity of cervix" . [] oboInOwl:hasDbXref "Wikipedia:Canal_of_the_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "cervical canal" . [] oboInOwl:hasDbXref "BTO:0002249" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "cervical canal of uterus" . [] oboInOwl:hasDbXref "Wikipedia:Canal_of_the_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "endocervical" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "NH3" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002127 ; owl:annotatedTarget obo:CL_0000911 . [] oboInOwl:hasDbXref "BTO:0002249", "Wikipedia:Canal_of_the_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "endocervical canal" . [] oboInOwl:hasDbXref "Wikipedia:Canal_of_the_cervix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013761 ; owl:annotatedTarget "endocervix" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013765 ; owl:annotatedTarget "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0013765 ; owl:annotatedTarget "EMAPA:37843" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20581831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002127 ; owl:annotatedTarget "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." . [] oboInOwl:hasDbXref "MGI:smb", "VT:0006168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013766 ; owl:annotatedTarget "A fold of skin of the upper eyelid that partially covers the inner corner of the eye." . [] oboInOwl:hasDbXref "FMA:59370" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013766 ; owl:annotatedTarget "medial canthic fold" . [] oboInOwl:hasDbXref "FMA:59370" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013766 ; owl:annotatedTarget "palpebronasal fold" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013766 ; owl:annotatedTarget "plica palpebronasalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget obo:UBERON_0004529 . [] oboInOwl:hasDbXref "Wikipedia:Frontal_process_of_maxilla" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "A plate of bone from the maxilla that that projects upward, medialward, and backward, by the side of the nose, forming part of its lateral boundary[WP,modified]." . [] oboInOwl:hasDbXref "FMA:52894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "processus frontalis (maxilla)" . [] oboInOwl:hasDbXref "FMA:52894" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "frontal appendage of maxilla" . [] oboInOwl:hasDbXref "Wikipedia:Frontal_process_of_maxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "frontal process of the maxilla" . [] oboInOwl:hasDbXref "Wikipedia:Frontal_process_of_maxilla" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "nasal process of maxilla" . [] oboInOwl:hasDbXref "Wikipedia:Frontal_process_of_maxilla" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0013767 ; owl:annotatedTarget "processus frontalis maxillae" . [] oboInOwl:hasDbXref "Wikipedia:Great_vessels" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013768 ; owl:annotatedTarget "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013769 ; owl:annotatedTarget "An organ cavity that is part of a uterus." . [] oboInOwl:hasDbXref "FMA:17745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013769 ; owl:annotatedTarget "cavity of uterus" . [] oboInOwl:hasDbXref "FMA:17745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013769 ; owl:annotatedTarget "uterine cavity" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013771 ; owl:annotatedTarget "Line across midline connecting a left and right nipples." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013772 ; owl:annotatedTarget "A nipple that is in_the_left_side_of a body proper." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013773 ; owl:annotatedTarget "A nipple that is in_the_right_side_of a body proper." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013774 ; owl:annotatedTarget "A diaphysis that is part of a metatarsal bone." . [] oboInOwl:hasDbXref "FMA:33826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013774 ; owl:annotatedTarget "metatarsal bone diaphysis" . [] oboInOwl:hasDbXref "FMA:33826" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013774 ; owl:annotatedTarget "shaft of metatarsal bone" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002132 ; owl:annotatedTarget "A stomal cell of the ovary" . _:genid153761 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013776 ; owl:annotatedTarget "A zone of skin that is part of a palmar/plantar part of autopod." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001134 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0013777 ; owl:annotatedTarget _:genid155959 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013777 ; owl:annotatedTarget "A zone of skin that is part of a palmar part of manus." . [] oboInOwl:hasDbXref "FMA:38301" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013777 ; owl:annotatedTarget "palmar skin of hand" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002132 ; owl:annotatedTarget "ovarian stromal cell" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0013778 ; owl:annotatedTarget "A zone of skin that is part of a skin of pes." . [] oboInOwl:hasDbXref "FMA:37849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013778 ; owl:annotatedTarget "plantar skin of foot" . [] oboInOwl:hasDbXref "FMA:37849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013778 ; owl:annotatedTarget "skin of plantar part of foot" . [] oboInOwl:hasDbXref "FMA:37849" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0013778 ; owl:annotatedTarget "skin of sole of foot" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014371 ; owl:annotatedTarget _:genid155976 . [] oboInOwl:hasDbXref "ZFA:0000571", "ZFA:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014371 ; owl:annotatedTarget "Embryonic structure that gives rise to the telencephalon." . [] oboInOwl:hasDbXref "ZFA:0000571" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014371 ; owl:annotatedTarget "presumptive telencephalon" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/intrinsic+muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014375 ; owl:annotatedTarget "Any of the intrinsic muscles of the manus (hand)." . [] oboInOwl:hasDbXref "FMA:42380" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014375 ; owl:annotatedTarget "intrinsic muscle of hand" . _:genid153791 oboInOwl:source "FMA" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget obo:UBERON_0014375 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001134 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/Thenar+muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget "Any of the muscles of the thenar eminence, a raised fleshy area on the palm of the hand near the base of the thumb." . [] oboInOwl:hasDbXref "Wikipedia:Thenar_eminence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget "thenar compartment" . [] oboInOwl:hasDbXref "Wikipedia:Thenar_eminence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget "thenar eminence" . [] oboInOwl:hasDbXref "Wikipedia:Thenar_eminence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget "thenar muscle" . [] oboInOwl:hasDbXref "Wikipedia:Thenar_eminence" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014376 ; owl:annotatedTarget "thenar muscles" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "NH3" . _:genid153801 oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/intrinsic+muscles" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014378 ; owl:annotatedTarget "Any of the intrinsic muscles of the pes (foot)." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005969 . [] oboInOwl:hasDbXref "FMA:65020" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014378 ; owl:annotatedTarget "intrinsic muscle of foot" . [] oboInOwl:hasDbXref "Wikipedia:Hair_whorl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014381 ; owl:annotatedTarget "A patch of hair growing in the opposite direction of the rest of the hair." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014382 ; owl:annotatedTarget "A collection of hairs that is part of a craniocervical region." . [] oboInOwl:hasDbXref "Wikipedia:Aryepiglottic_fold" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "The entrance of the larynx is a triangular opening, narrow in front, wide behind, and sloping obliquely downward and backward. It is bounded, in front, by the epiglottis; behind, by the apices of the arytenoid cartilages, the corniculate cartilages, and the interarytenoid notch; and on either side, by a fold of mucous membrane, enclosing ligamentous and muscular fibers, stretched between the side of the epiglottis and the apex of the arytenoid cartilage; this is the aryepiglottic fold, on the posterior part of the margin of which the cuneiform cartilage forms a more or less distinct whitish prominence, the cuneiform tubercle. These folds form the upper borders of the quadrangular membrane." . [] oboInOwl:source "ncithesaurus:Aryteno-epiglottic_Fold" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "UMLS:C1510944" . [] oboInOwl:hasDbXref "FMA:55448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "ary-epiglottic fold" . _:genid153814 oboInOwl:hasDbXref "Wikipedia:Aryepiglottic_fold" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "aryepiglottic folds" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003316 . [] oboInOwl:hasDbXref "Wikipedia:Aryepiglottic_fold" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "aryepiglottic sphincter" . [] oboInOwl:hasDbXref "Wikipedia:Aryepiglottic_fold" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "aryepiglottis" . [] oboInOwl:hasDbXref "Wikipedia:Aryepiglottic_fold" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014385 ; owl:annotatedTarget "plica aryepiglottica" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002134 ; owl:annotatedTarget obo:CL_0002132 . _:genid153820 oboInOwl:hasDbXref "HPO:curators", "Wikipedia:Endplates" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014386 ; owl:annotatedTarget "Either of the the top and bottom portions of the vertebral bodies that interface with the vertebral discs. It is composed of a layer of thickened cancellous bone." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002331 . (obo:UBERON_0003104 [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002342 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/248" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014387 ; owl:annotatedTarget "Mesenchyme that develops_from the neural crest[Automatically generated definition]." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002134 ; owl:annotatedTarget "A stromal cell of the ovarian medulla." . [] oboInOwl:hasDbXref "MGI:anna", "MP:0011843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014388 ; owl:annotatedTarget "The simple cuboidal epithelium lining the lumen of kidney collecting ducts." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014388 ; owl:annotatedTarget "EMAPA:37885" . [] oboInOwl:hasDbXref "MGI:smb", "MP:0006256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014389 ; owl:annotatedTarget "A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014389 ; owl:annotatedTarget "gustatory papillae" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014389 ; owl:annotatedTarget "taste papillae" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014390 ; owl:annotatedTarget "A muscular coat that is part of a ileum." . [] oboInOwl:hasDbXref "FMA:14958" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014390 ; owl:annotatedTarget "muscularis externa of ileum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014390 ; owl:annotatedTarget "ileal smooth muscle" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014390 ; owl:annotatedTarget "muscularis propria of ileum" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014390 ; owl:annotatedTarget "smooth muscle of ileum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014391 ; owl:annotatedTarget "A sweat gland that is part of the skin of the palmar part of the manus or plantar part of the pes." . [] oboInOwl:source "MP:0000675" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0014391 ; owl:annotatedTarget "in mice these are the only sweat glands present" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014392 ; owl:annotatedTarget "Sweat that is produced by the glands on the palmar and plantar surfaces." . [] oboInOwl:hasDbXref "FMA:63084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014392 ; owl:annotatedTarget "palm sweat" . [] oboInOwl:hasDbXref "FMA:63084" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014392 ; owl:annotatedTarget "palmar sweat" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014393 ; owl:annotatedTarget "Sweat that is produced by the glands of the axilla." . [] oboInOwl:hasDbXref "FMA:63085" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014393 ; owl:annotatedTarget "axillary sweat" . _:genid153868 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003916 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000995 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006003 . [] oboInOwl:hasDbXref "MP:0008900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014394 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the uterus." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014394 ; owl:annotatedTarget "EMAPA:37979" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014395 ; owl:annotatedTarget "A proximal mesopodial endochondral element that is composed primarily of a bone tissue." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014398 ; owl:annotatedTarget "Muscle that is part of the respiratory system." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014399 ; owl:annotatedTarget "An anatomical space that is enclosed by a sinusoid." . [] oboInOwl:hasDbXref "FMA:63133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014399 ; owl:annotatedTarget "lumen of sinusoid" . [] oboInOwl:hasDbXref "FMA:63133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014399 ; owl:annotatedTarget "sinusoid lumen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014400 ; owl:annotatedTarget "A sinusoidal space that is part of a hepatic sinusoid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "R-717" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget obo:CL_0002139 . [] oboInOwl:hasDbXref "FMA:262090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014400 ; owl:annotatedTarget "lumen of hepatic sinusoid" . [] oboInOwl:hasDbXref "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014401 ; owl:annotatedTarget "Any member of the network of tubes that return blood from the renal tissues to the systemic circulation." . [] oboInOwl:external_ontology "MA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0014401 ; owl:annotatedTarget "we follow MA and MP in distinguishing the venous blood vessel from the vein. The kidney cortex vein is not considered a renal vein, nor is the vasa recta" . [] oboInOwl:hasDbXref "MA:0002591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014401 ; owl:annotatedTarget "kidney venous blood vessel" . [] oboInOwl:hasDbXref "EMAPA:31450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014401 ; owl:annotatedTarget "kidney venous system" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17846148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002138 ; owl:annotatedTarget "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." . [] oboInOwl:hasDbXref "AEO:0000174", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014402 ; owl:annotatedTarget "A part of the body present only in a specific gender." . [] oboInOwl:hasDbXref "AEO:0000174" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014402 ; owl:annotatedTarget "gender-specific anatomical structure" . [] oboInOwl:hasDbXref "AEO:0000175", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014403 ; owl:annotatedTarget "A part of the body present only in males." . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:12768659" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002139 ; owl:annotatedTarget "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." . [] oboInOwl:hasDbXref "WBbt:0005757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014403 ; owl:annotatedTarget "male-specific" . [] oboInOwl:hasDbXref "AEO:0000176", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014404 ; owl:annotatedTarget "A part of the body present only in females." . [] oboInOwl:hasDbXref "MURDOCH:865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014411 ; owl:annotatedTarget "On the dorsal border of the wing of the ilium , at it's junction with the shaft is a cut away. This forms the Greater sciatic notch. The sciatic nerve runs over the notch in passage to the hindlimb." . _:genid153928 oboInOwl:source "HP:0010456" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0014411 ; owl:annotatedTarget "deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium[HP:0010456]." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011962 . [] oboInOwl:hasDbXref "Wikipedia:Greater_sciatic_notch" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014411 ; owl:annotatedTarget "incisura ischiadica major" . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/sciatic+notch" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014430 ; owl:annotatedTarget "Either of two notches on the dorsal border of the hip bone on each side that when closed off by ligaments form the corresponding sciatic foramina." . [] oboInOwl:hasDbXref "MURDOCH:931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014437 ; owl:annotatedTarget "Is part of the pelvis on the edge of the wing of the ilium. Round in shape, dorsal to the pubis and ischium. Acts as structrure that muscles can attach too." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014437 ; owl:annotatedTarget "EMAPA:37602" . [] oboInOwl:hasDbXref "Wikipedia:Superior_pubic_ramus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014438 ; owl:annotatedTarget "The superior pubic ramus is a part of the pubic bone which forms a portion of the obturator foramen. It extends from the body to the median plane where it articulates with its fellow of the opposite side. It is conveniently described in two portions, viz. , a medial flattened part and a narrow lateral prismoid portion." . [] oboInOwl:hasDbXref "FMA:16988" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014438 ; owl:annotatedTarget "superior ramus of pubis" . [] oboInOwl:hasDbXref "Wikipedia:Superior_pubic_ramus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014438 ; owl:annotatedTarget "superior rami of the pubes" . [] oboInOwl:hasDbXref "Wikipedia:Superior_pubic_ramus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014438 ; owl:annotatedTarget "superior ramus of the pubis" . _:genid153939 oboInOwl:hasDbXref "Wikipedia:Inferior_pubic_ramus" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014439 ; owl:annotatedTarget "The inferior pubic ramus is thin and flattened. It passes lateralward and downward from the medial end of the superior ramus; it becomes narrower as it descends and joins with the inferior ramus of the ischium below the obturator foramen." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011962 . [] oboInOwl:hasDbXref "FMA:16989" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014439 ; owl:annotatedTarget "inferior ramus of pubis" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_pubic_ramus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014439 ; owl:annotatedTarget "inferior rami of the pubes" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_pubic_ramus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014439 ; owl:annotatedTarget "inferior ramus of the pubis" . [] oboInOwl:hasDbXref "MURDOCH:100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014445 ; owl:annotatedTarget "The acetabular fossa is the roughened depression in the centre of the acetabulum, surrounded by the lunate acetabular surface and the acetabular notch. The acetabular fossa provides an insertion point for the teres ligaments that secure the femoral head." . [] oboInOwl:hasDbXref "Wikipedia:Acetabular_fossa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014445 ; owl:annotatedTarget "fossa acetabularis" . [] oboInOwl:hasDbXref "FMA:17269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014445 ; owl:annotatedTarget "fossa acetabularis (acetabuli)" . [] oboInOwl:hasDbXref "Wikipedia:Acetabular_fossa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014445 ; owl:annotatedTarget "fossa acetabuli" . [] oboInOwl:hasDbXref "Wikipedia:Acetabular_notch" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014446 ; owl:annotatedTarget "The acetabulum presents below a deep notch, the acetabular notch, which is continuous with a circular non-articular depression, the acetabular fossa, at the bottom of the cavity: this depression is perforated by numerous apertures, and lodges a mass of fat. The notch is converted into a foramen by the transverse ligament; through the foramen nutrient vessels and nerves enter the joint; the margins of the notch serve for the attachment of the ligament of the head of the femur." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014451 ; owl:annotatedTarget "A taste bud that is located on the tongue, situated on a gustatory papilla." . [] oboInOwl:hasDbXref "MP:0006260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014451 ; owl:annotatedTarget "gustatory papillae taste bud" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014452 ; owl:annotatedTarget "A gustatory epithelium that is part of a tongue." . [] oboInOwl:source "BIRNLEX:4099" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014452 ; owl:annotatedTarget "UMLS:C1179150" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014452 ; owl:annotatedTarget "lingual gustatory epithelium" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002140 ; owl:annotatedTarget obo:CL_0000317 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014453 ; owl:annotatedTarget "A gustatory epithelium that is part of a roof of mouth." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014453 ; owl:annotatedTarget "palatal gustatory epithelium" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002140 ; owl:annotatedTarget "A sebum secreting cell of the skin that secretes sebum into the hair follicles." . [] oboInOwl:hasDbXref "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "Subcutaneous adipose tissue that is located in the peritoneal cavity." . [] oboInOwl:source "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively[BTO:0004041]." . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "abdominal fat" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "intra-abdominal fat" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "organ fat" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "visceral adipose tissue" . [] oboInOwl:hasDbXref "BTO:0004041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014454 ; owl:annotatedTarget "visceral fat" . [] oboInOwl:hasDbXref "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014455 ; owl:annotatedTarget "Subcutaneous adipose tissue that is located in the abdominal region." . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "[NH3]" . [] oboInOwl:hasDbXref "ISBN:0-683-40008-8", "MP:0003685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery." . [] oboInOwl:source "http://medical-dictionary.thefreedictionary.com/cardiac+ganglion" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery[http://medical-dictionary.thefreedictionary.com/cardiac+ganglion]." . [] oboInOwl:hasDbXref "MP:0003685" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "Wrisberg ganglion" . [] oboInOwl:hasDbXref "FMA:77582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "cardiac ganglia set" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "ganglia cardiaca" . [] oboInOwl:hasDbXref "FMA:77582" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "ganglion of Wrisberg" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014463 ; owl:annotatedTarget "cardiac ganglia" . [] oboInOwl:hasDbXref "MP:0008902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014464 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the kidney." . [] oboInOwl:hasDbXref "MP:0008902" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014464 ; owl:annotatedTarget "perirenal fat pad" . [] oboInOwl:hasDbXref "Wikipedia:Rib_cage", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014477 ; owl:annotatedTarget "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." . [] oboInOwl:hasDbXref "EHDAA2:0002013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014477 ; owl:annotatedTarget "thoracic skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014478 ; owl:annotatedTarget "Subdivision of skeletal system that consists of all ribs and rib joints in an organism. In many vertebrates this consists of the combination of the rib cage and all rib joints, but some vertebrates have ribs outside the thoracic rib cage." . [] oboInOwl:hasDbXref "TAO:0002100" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014478 ; owl:annotatedTarget "rib series" . [] oboInOwl:hasDbXref "FMA:265719" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014478 ; owl:annotatedTarget "set of all ribs" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002144 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014483 ; owl:annotatedTarget "A distal phalanx that is part of a digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014483 ; owl:annotatedTarget "digit 1 distal phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014483 ; owl:annotatedTarget "distal phalanx of digit I" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002144 ; owl:annotatedTarget "An endothelial cell found in capillaries." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014484 ; owl:annotatedTarget "A distal phalanx that is part of a digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014484 ; owl:annotatedTarget "digit 2 distal phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014484 ; owl:annotatedTarget "distal phalanx of digit II" . [] oboInOwl:hasDbXref "Wikipedia:Coffin_bone", "Wikipedia:Equine_forelimb_anatomy#Distal_phalanx", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "A distal phalanx that is part of a digit 3. In odd-toes ungulates (Perissodactyla e.g. horses) this is called the coffin bone. In even-toed ungulates (Artiodactyla e.g cattle) this is associated with the medial claw." . [] oboInOwl:source "Wikipedia:Coffin_bone" ; oboInOwl:taxon "NCBITaxon:9788" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "the bottommost bone in the equine leg and is encased by the hoof capsule. The distal phalanx articulates with both the middle phalanx and the distal sesamoid, forming the distal interphalangeal joint[Wikipedia:Coffin_bone]" . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "digit 3 distal phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "distal phalanx of digit III" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "equine 3rd phalanx of digit 3" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "equine distal phalanx" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "coffin bone" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "medial claw of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "medial claw of ruminant hoof" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "medial ungual phalanx of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:9787" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014485 ; owl:annotatedTarget "pedal bone" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002145 ; owl:annotatedTarget "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "A distal phalanx that is part of a digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "digit 4 distal phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "distal phalanx of digit IV" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "lateral claw of artiodactyl" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "lateral claw of ruminant hoof" . [] oboInOwl:hasDbXref "NCBITaxon:91561" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014486 ; owl:annotatedTarget "lateral ungual phalanx of artiodactyl" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014487 ; owl:annotatedTarget "A distal phalanx that is part of a digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014487 ; owl:annotatedTarget "digit 5 distal phalanx" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014487 ; owl:annotatedTarget "distal phalanx of digit V" . _:genid154083 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003216, obo:UBERON_5106049 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014488 ; owl:annotatedTarget "A middle phalanx that is part of a digit 2 [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014488 ; owl:annotatedTarget "middle phalanx of digit II" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014489 ; owl:annotatedTarget "A middle phalanx that is part of a digit 3 [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014489 ; owl:annotatedTarget "middle phalanx of digit III" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014490 ; owl:annotatedTarget "A middle phalanx that is part of a digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014490 ; owl:annotatedTarget "middle phalanx of digit IV" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "ammoniac" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014491 ; owl:annotatedTarget "A middle phalanx that is part of a digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014491 ; owl:annotatedTarget "middle phalanx of digit V" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:36267574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002148 ; owl:annotatedTarget "A cell found within the dental pulp." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014501 ; owl:annotatedTarget "A proximal phalanx that is part of a autopod digit 1 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014501 ; owl:annotatedTarget "digit I-1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014501 ; owl:annotatedTarget "proximal phalanx of digit I" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014502 ; owl:annotatedTarget "A proximal phalanx that is part of a autopod digit 2 [Automatically generated definition]." . _:genid154121 oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014502 ; owl:annotatedTarget "digit II-1" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006256 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014502 ; owl:annotatedTarget "proximal phalanx of digit II" . (obo:UBERON_0004302 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006050 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014503 ; owl:annotatedTarget "A proximal phalanx that is part of a autopod digit 3 [Automatically generated definition]." . _:genid154129 oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014503 ; owl:annotatedTarget "digit III-1" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002185 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014503 ; owl:annotatedTarget "proximal phalanx of digit III" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014504 ; owl:annotatedTarget "A proximal phalanx that is part of a autopod digit 4 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014504 ; owl:annotatedTarget "digit IV-1" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014504 ; owl:annotatedTarget "proximal phalanx of digit IV" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014505 ; owl:annotatedTarget "A proximal phalanx that is part of a autopod digit 5 [Automatically generated definition]." . [] oboInOwl:hasDbXref "PHENOSCAPE:wd" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014505 ; owl:annotatedTarget "digit V-1" . _:genid154146 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014505 ; owl:annotatedTarget "proximal phalanx of digit V" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014506 ; owl:annotatedTarget "A distal inter-phalangeal joint that is part of the 3rd digit." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014506 ; owl:annotatedTarget "distal interphalangeal joint of digit III" . _:genid154153 oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014506 ; owl:annotatedTarget "coffin joint" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007827 . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014506 ; owl:annotatedTarget "equine distal interphalangeal joint" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014506 ; owl:annotatedTarget "equine second interphalangeal joint of limb digit III" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002149 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "A distal inter-phalangeal joint that is part of the 3rd pedal digit." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "distal interphalangeal joint of pedal digit III" . [] oboInOwl:hasDbXref "FMA:35375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "distal interphalangeal joint of third digit of foot" . [] oboInOwl:hasDbXref "FMA:35375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "distal interphalangeal joint of third toe" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "equine distal interphalangeal joint of hindlimb" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014507 ; owl:annotatedTarget "hindlimb coffin joint" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002149 ; owl:annotatedTarget "An epithelial cell of the uterus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "A distal inter-phalangeal joint that is part of the 3rd manual digit." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "distal interphalangeal joint of manual digit III" . [] oboInOwl:hasDbXref "FMA:35337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "distal interphalangeal joint of middle finger" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "equine distal interphalangeal joint of forelimb" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "equine second interphalangeal joint of forelimb digit III" . [] oboInOwl:hasDbXref "NCBITaxon:9788", "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014508 ; owl:annotatedTarget "forelimb coffin joint" . [] oboInOwl:hasDbXref "FMA:83856" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014530 ; owl:annotatedTarget "lamina of neuraxis" . [] oboInOwl:hasDbXref "FMA:83856" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014530 ; owl:annotatedTarget "neuraxis lamina" . [] oboInOwl:hasDbXref "FMA:62449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014531 ; owl:annotatedTarget "diencephalon lamina" . [] oboInOwl:hasDbXref "FMA:62449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014531 ; owl:annotatedTarget "lamina of diencephalon" . [] oboInOwl:hasDbXref "FMA:67951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014532 ; owl:annotatedTarget "cerebral hemisphere lamina" . [] oboInOwl:hasDbXref "FMA:67951" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014532 ; owl:annotatedTarget "lamina of cerebral hemisphere" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014538 ; owl:annotatedTarget "A subdivision of the central canal of the spinal cord along its anterior-posterior axis. This is typically subdivided into cervical, thoracic, lumbar and sacral segments." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "amoniaco" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002153 ; owl:annotatedTarget "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." . [] oboInOwl:hasDbXref "BIRNLEX:717" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014538 ; owl:annotatedTarget "regional part of spinal cord central canal" . _:genid154205 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0001107 ; owl:someValuesFrom obo:UBERON_0002956, obo:UBERON_0012141 . [] oboInOwl:hasDbXref "http://neurolex.org/wiki/Category:White_laminae_of_cerebellum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex." . [] oboInOwl:source "BIRNLEX:1105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "UMLS:C0228472" . [] oboInOwl:source "BIRNLEX:1105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "neuronames:163" . [] oboInOwl:hasDbXref "BIRNLEX:1105" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "white laminae of cerebellum" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002159 ; owl:annotatedTarget "Epithelial cells derived from general body ectoderm and ectoderm placodes." . [] oboInOwl:hasDbXref "NeuroNames:163" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus cinguli" . [] oboInOwl:hasDbXref "NeuroNames:163" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus gyri cingulatus" . [] oboInOwl:hasDbXref "NeuroNames:163" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus gyri cinguli" . [] oboInOwl:hasDbXref "NeuroNames:163" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus of gyrus fornicatus" . [] oboInOwl:hasDbXref "NeuroNames:163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus of the cingulate gyrus" . [] oboInOwl:hasDbXref "NeuroNames:163" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "isthmus-2" . [] oboInOwl:hasDbXref "BIRNLEX:1105" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014540 ; owl:annotatedTarget "laminae albae of cerebellar cortex" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014541 ; owl:annotatedTarget obo:UBERON_0014538 . [] oboInOwl:hasDbXref "BIRNLEX:1395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014541 ; owl:annotatedTarget "Part of spinal cord central canal contained in the thoracic spinal cord. It is continuous rostrally with the cervical spinal cord central canal and caudally with the lumbar spinal cord central canal." . [] oboInOwl:source "BIRNLEX:1395" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014541 ; owl:annotatedTarget "UMLS:C0228637" . [] oboInOwl:hasDbXref "BIRNLEX:1395" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014541 ; owl:annotatedTarget "thoracic spinal cord central canal" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014542 ; owl:annotatedTarget obo:UBERON_0014538 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002166 ; owl:annotatedTarget obo:CL_0002159 . [] oboInOwl:hasDbXref "BIRNLEX:1511" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014542 ; owl:annotatedTarget "Part of central canal contained within the cervical spinal cord. It is continuous caudally with the thoracic spinal cord central canal and rostrally with the fourth ventricle of the brain via the obex." . [] oboInOwl:source "BIRNLEX:1511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014542 ; owl:annotatedTarget "UMLS:C0228620" . [] oboInOwl:hasDbXref "BIRNLEX:1511" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014542 ; owl:annotatedTarget "cervical spinal cord central canal" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014543 ; owl:annotatedTarget obo:UBERON_0014538 . [] oboInOwl:hasDbXref "BIRNLEX:1604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014543 ; owl:annotatedTarget "Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord." . _:genid154239 oboInOwl:source "BIRNLEX:1604" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014543 ; owl:annotatedTarget "UMLS:C0228644" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003051 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651", "ISBN:0815129521" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002166 ; owl:annotatedTarget "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." . [] oboInOwl:hasDbXref "BIRNLEX:1604" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014543 ; owl:annotatedTarget "lumbar spinal cord central canal" . _:genid154241 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0014538 [ a owl:Restriction ; owl:onProperty core:subdivision_of ; owl:someValuesFrom obo:UBERON_0005843 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006232 . [] oboInOwl:hasDbXref "NLXANAT:1010008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014547 ; owl:annotatedTarget "Part of spinal cord central canal contained in the sacral spinal cord. It is continuous rostrally with the spinal cord central canal of the lumbar cord." . [] oboInOwl:hasDbXref "NLXANAT:1010008" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014547 ; owl:annotatedTarget "sacral spinal cord central canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014610 ; owl:annotatedTarget "A ventral horn of spinal cord that is part of a thoracic spinal cord." . [] oboInOwl:source "BIRNLEX:1410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014610 ; owl:annotatedTarget "UMLS:C0228632" . [] oboInOwl:source "BIRNLEX:1410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014610 ; owl:annotatedTarget "UMLS:C1288552" . [] oboInOwl:hasDbXref "BIRNLEX:1410" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014610 ; owl:annotatedTarget "thoracic spinal cord ventral horn" . [] oboInOwl:hasDbXref "BIRNLEX:1410" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014610 ; owl:annotatedTarget "thoracic spinal cord anterior horn" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014613 ; owl:annotatedTarget "A gray matter of spinal cord that is part of a cervical spinal cord." . [] oboInOwl:source "BIRNLEX:1521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014613 ; owl:annotatedTarget "UMLS:C0228610" . [] oboInOwl:hasDbXref "BIRNLEX:1521" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014613 ; owl:annotatedTarget "cervical spinal cord gray matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014614 ; owl:annotatedTarget "A white matter of spinal cord that is part of a cervical spinal cord." . [] oboInOwl:source "BIRNLEX:1531" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014614 ; owl:annotatedTarget "UMLS:C0228616" . [] oboInOwl:hasDbXref "BIRNLEX:1531" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014614 ; owl:annotatedTarget "cervical spinal cord white matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014621 ; owl:annotatedTarget "A ventral horn of spinal cord that is part of a cervical spinal cord." . [] oboInOwl:source "BIRNLEX:1680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014621 ; owl:annotatedTarget "UMLS:C0228615" . [] oboInOwl:source "BIRNLEX:1680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014621 ; owl:annotatedTarget "UMLS:C1278740" . [] oboInOwl:hasDbXref "BIRNLEX:1680" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014621 ; owl:annotatedTarget "cervical spinal cord ventral horn" . [] oboInOwl:hasDbXref "BIRNLEX:1680" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014621 ; owl:annotatedTarget "cervical spinal cord anterior horn" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014636 ; owl:annotatedTarget "A gray matter of spinal cord that is part of a thoracic spinal cord." . _:genid154284 oboInOwl:source "BIRNLEX:980" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014636 ; owl:annotatedTarget "UMLS:C0228627" ; owl:intersectionOf (obo:UBERON_0002049 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001255 ] ) . [] oboInOwl:hasDbXref "BIRNLEX:980" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014636 ; owl:annotatedTarget "thoracic spinal cord gray matter" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:7143026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002167 ; owl:annotatedTarget "A specialized cell involved in sensory perception of smell." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014637 ; owl:annotatedTarget "A white matter of spinal cord that is part of a thoracic spinal cord." . [] oboInOwl:source "BIRNLEX:999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014637 ; owl:annotatedTarget "UMLS:C0228633" . [] oboInOwl:source "BIRNLEX:999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014637 ; owl:annotatedTarget "UMLS:C1288557" . [] oboInOwl:hasDbXref "BIRNLEX:999" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014637 ; owl:annotatedTarget "thoracic spinal cord white matter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014639 ; owl:annotatedTarget "A sulcus of brain that is part of a frontal cortex." . [] oboInOwl:source "ncithesaurus:Frontal_Sulcus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014639 ; owl:annotatedTarget "UMLS:C0459388" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16134 ; owl:annotatedTarget "spirit of hartshorn" . [] oboInOwl:hasDbXref "HBA:FLs" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014639 ; owl:annotatedTarget "frontal lobe sulci" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014649 ; owl:annotatedTarget "A white matter that is part of a medulla oblongata." . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014649 ; owl:annotatedTarget "substantia alba medullae oblongatae" . [] oboInOwl:hasDbXref "FMA:83944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014649 ; owl:annotatedTarget "white matter of medulla" . [] oboInOwl:hasDbXref "FMA:83944" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014649 ; owl:annotatedTarget "white substance of medulla" . [] oboInOwl:hasDbXref "BAMS:mw" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014649 ; owl:annotatedTarget "medullary white matter" . [] oboInOwl:hasDbXref "FMA:35334" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014668 ; owl:annotatedTarget "distal interphalangeal joint of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014668 ; owl:annotatedTarget "distal interphalangeal joint of manual digit II" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014670 ; owl:annotatedTarget "distal interphalangeal joint of manual digit IV" . [] oboInOwl:hasDbXref "FMA:35340" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014670 ; owl:annotatedTarget "distal interphalangeal joint of ring finger" . [] oboInOwl:hasDbXref "FMA:35343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014671 ; owl:annotatedTarget "distal interphalangeal joint of little finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014671 ; owl:annotatedTarget "distal interphalangeal joint of manural digit V" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014672 ; owl:annotatedTarget "distal interphalangeal joint of pedal digit II" . [] oboInOwl:hasDbXref "FMA:35369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014672 ; owl:annotatedTarget "distal interphalangeal joint of second digit of foot" . [] oboInOwl:hasDbXref "FMA:35369" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014672 ; owl:annotatedTarget "distal interphalangeal joint of second toe" . [] oboInOwl:hasDbXref "FMA:35387" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014674 ; owl:annotatedTarget "distal interphalangeal joint of fourth digit of foot" . [] oboInOwl:hasDbXref "FMA:35387" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014674 ; owl:annotatedTarget "distal interphalangeal joint of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014674 ; owl:annotatedTarget "distal interphalangeal joint of pedal digit IV" . [] oboInOwl:hasDbXref "FMA:35393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014675 ; owl:annotatedTarget "distal interphalangeal joint of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:35393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014675 ; owl:annotatedTarget "distal interphalangeal joint of fifth toe" . [] oboInOwl:hasDbXref "FMA:35393" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014675 ; owl:annotatedTarget "distal interphalangeal joint of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014675 ; owl:annotatedTarget "distal interphalangeal joint of pedal digit V" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:12014572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002170 ; owl:annotatedTarget "A keratinized cell located in the hard palate or gingiva." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014677 ; owl:annotatedTarget "A distal interphalangeal joint that is part of a digit 2." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014677 ; owl:annotatedTarget "distal interphalangeal joint of digit II" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014679 ; owl:annotatedTarget "A distal interphalangeal joint that is part of a digit 4." . _:genid154361 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014679 ; owl:annotatedTarget "distal interphalangeal joint of digit IV" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000002 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014680 ; owl:annotatedTarget "A distal interphalangeal joint that is part of a digit 5." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014680 ; owl:annotatedTarget "distal interphalangeal joint of digit V" . [] oboInOwl:hasDbXref "Wikipedia:Angular_vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014686 ; owl:annotatedTarget "The angular vein formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the external nasal veins of the ala nasi, and communicates with the superior ophthalmic vein through the nasofrontal vein, thus establishing an important anastomosis between the anterior facial vein and the cavernous sinus." . [] oboInOwl:hasDbXref "ncithesaurus:Temporal_Sulcus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014687 ; owl:annotatedTarget "Any of three grooves in the temporal lobe including the inferior, middle, and superior temporal sulci." . [] oboInOwl:hasDbXref "HBA:TLs" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014687 ; owl:annotatedTarget "temporal lobe sulci" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014693 ; owl:annotatedTarget _:genid156572 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014695 ; owl:annotatedTarget _:genid156579 . [] oboInOwl:hasDbXref "Wikipedia:Deep_auricular_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014695 ; owl:annotatedTarget "The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint." . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014699 ; owl:annotatedTarget obo:UBERON_0014701 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014699 ; owl:annotatedTarget "A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014701 ; owl:annotatedTarget "A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002177 ; owl:annotatedTarget obo:CL_0000642 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014702 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014702 ; owl:annotatedTarget _:genid156602 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014702 ; owl:annotatedTarget "An epithelium that is part of a frontonasal prominence." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002177 ; owl:annotatedTarget "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014703 ; owl:annotatedTarget "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014704 ; owl:annotatedTarget _:genid156616 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014704 ; owl:annotatedTarget "An anatomical space that is enclosed by a pleuroperitoneal canal." . [] oboInOwl:hasDbXref "EMAPA:25034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014704 ; owl:annotatedTarget "pleuro-peritoneal canal cavity" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014705 ; owl:annotatedTarget obo:UBERON_0000490 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014705 ; owl:annotatedTarget _:genid156625 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014705 ; owl:annotatedTarget "An epithelium that is part of a median lingual swelling." . [] oboInOwl:hasDbXref "EMAPA:17188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014705 ; owl:annotatedTarget "tuberculum impar epitheilium" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014706 ; owl:annotatedTarget obo:UBERON_0007501 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014706 ; owl:annotatedTarget _:genid156630 . [] oboInOwl:hasDbXref "EHDAA2:0001147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014706 ; owl:annotatedTarget "metanephros primitive collecting ducts" . [] oboInOwl:hasDbXref "EMAPA:17646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014706 ; owl:annotatedTarget "primitive collecting duct" . [] oboInOwl:hasDbXref "ncithesaurus:Interlobular_Duct" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014716 ; owl:annotatedTarget "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014717 ; owl:annotatedTarget "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." . [] oboInOwl:hasDbXref "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014719 ; owl:annotatedTarget "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." . [] oboInOwl:hasDbXref "http://www.siumed.edu/~dking2/intro/glands.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014720 ; owl:annotatedTarget "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002178 ; owl:annotatedTarget obo:CL_0002251 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014762 ; owl:annotatedTarget "An element formed from the fusion of metapodium bones 2, 3 and 4 (i.e. either metatarsals 2-4 or metacarpals 3-4)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014762 ; owl:annotatedTarget "fused central metapodials" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014762 ; owl:annotatedTarget "fused metapodials 2-4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014762 ; owl:annotatedTarget "metapodial 2+3+4" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002178 ; owl:annotatedTarget "An epithelial cell found in the lining of the stomach." . _:genid154476 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002374 ; owl:someValuesFrom obo:UBERON_0003653, obo:UBERON_0012469 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "An element formed from the fusion of metapodium bones 2, 3 and 4 in the pedal autopod." . [] oboInOwl:source "PMID:22135653" ; oboInOwl:taxon "NCBITaxon:51337" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "The cannon bone of the 3-toed jerboa (jaculus jaculus) is the postnatal fusion of the 3 central metatarsals, which are distinct ossified elements prenatally" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "fused central metatarsals" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "fused metatarsals 2-4" . [] oboInOwl:hasDbXref "NCBITaxon:51337" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "cannon bone" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014763 ; owl:annotatedTarget "metatarsal 2+3+4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014768 ; owl:annotatedTarget "A blood vessel that drains from from an upper eyelid." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014768 ; owl:annotatedTarget "venae palpebrales superiores" . (obo:UBERON_0001638 [ a owl:Restriction ; owl:onProperty obo:RO_0002179 ; owl:someValuesFrom obo:UBERON_0001711 ] ) . ( ) . _:genid154495 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0000076, obo:UBERON_0014686 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014769 ; owl:annotatedTarget "A blood vessel that drains from from an eyelid." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014769 ; owl:annotatedTarget "palpebral veins" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014769 ; owl:annotatedTarget "venae palpebrales" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014770 ; owl:annotatedTarget "An artery that supplies blood to an eyelid." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014775 ; owl:annotatedTarget "A neuromere that is part of the presumptive forebrain." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014776 ; owl:annotatedTarget "A neuromere that is part of the presumptive midbrain." . [] oboInOwl:hasDbXref "EHDAA2:0004352" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014776 ; owl:annotatedTarget "mesomere group" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002180 ; owl:annotatedTarget obo:CL_0002178 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014777 ; owl:annotatedTarget "A neuromere that is part of the presumptive spinal cord." . [] oboInOwl:hasDbXref "TAO:0001332" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014777 ; owl:annotatedTarget "spinal neuromeres" . [] oboInOwl:hasDbXref "TAO:0001332" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014777 ; owl:annotatedTarget "spinal cord segment" . [] oboInOwl:hasDbXref "Wikipedia:Palatine_aponeurosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014780 ; owl:annotatedTarget "Attached to the posterior border of the hard palate is a thin, firm fibrous lamella called the palatine aponeurosis, which supports the muscles and gives strength to the soft palate. It is thicker above than below, where it becomes very thin and difficult to define. Laterally it is continuous with the pharyngeal aponeurosis. It serves as the insertion for the Tensor veli palatini and Levator veli palatini, and the origin for the Musculus uvulae, Palatopharyngeus, and Palatoglossus. It provides support for the soft palate." . [] oboInOwl:hasDbXref "FMA:49429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014780 ; owl:annotatedTarget "aponeurosis of tensor veli palatini" . [] oboInOwl:hasDbXref "Wikipedia:Palatine_aponeurosis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014780 ; owl:annotatedTarget "aponeurosis palatina" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002180 ; owl:annotatedTarget "A mucous cell in the epithelium of the stomach." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014783 ; owl:annotatedTarget "Any muscle organ that is part of a cloaca." . ( ) . [] oboInOwl:hasDbXref "Wikipedia:Lingual_septum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014790 ; owl:annotatedTarget "The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ." . [] oboInOwl:hasDbXref "FMA:54813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014790 ; owl:annotatedTarget "septum of tongue" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014790 ; owl:annotatedTarget "median fibrous septum" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014790 ; owl:annotatedTarget "septum of tongue" . [] oboInOwl:hasDbXref "Wikipedia:Lingual_septum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014790 ; owl:annotatedTarget "tongue septum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014791 ; owl:annotatedTarget "Any collection of muscles that is part of the forelimb stylopod region [Automatically generated definition]." . [] oboInOwl:hasDbXref "FMA:50202" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014791 ; owl:annotatedTarget "arm musculature" . [] oboInOwl:hasDbXref "FMA:50202" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014791 ; owl:annotatedTarget "muscle group of arm" . [] oboInOwl:hasDbXref "FMA:50202" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014791 ; owl:annotatedTarget "musculature of arm" . [] oboInOwl:hasDbXref "FMA:50202" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014791 ; owl:annotatedTarget "set of muscles of arm" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014792 ; owl:annotatedTarget "Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014792 ; owl:annotatedTarget "EMAPA:37864" . [] oboInOwl:hasDbXref "FMA:71297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014792 ; owl:annotatedTarget "muscles of lower limb" . [] oboInOwl:hasDbXref "FMA:71297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014792 ; owl:annotatedTarget "musculature of lower limb" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014792 ; owl:annotatedTarget "musculi membri inferioris" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "EMAPA:37861" . [] oboInOwl:hasDbXref "FMA:71296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "muscles of upper limb" . [] oboInOwl:hasDbXref "FMA:71296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "musculature of upper limb" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "musculi membri superioris" . [] oboInOwl:hasDbXref "FMA:71296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "set of muscles of upper limb" . [] oboInOwl:hasDbXref "FMA:71296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0014793 ; owl:annotatedTarget "upper limb musculature" . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014794 ; owl:annotatedTarget _:genid156778 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014794 ; owl:annotatedTarget "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002183 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:source "prolog" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014795 ; owl:annotatedTarget _:genid156785 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014795 ; owl:annotatedTarget "Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin)." . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "A ring of fibrous tissue surrounding the optic nerve at its entrance at the apex of the orbit." . [] oboInOwl:hasDbXref "FMA:49071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "anulus of Zinn" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "anulus tendineus communis" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002183 ; owl:annotatedTarget "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." . [] oboInOwl:hasDbXref "FMA:49071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "common annular tendon" . [] oboInOwl:hasDbXref "FMA:49071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "common anular tendon" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "annulus of Zinn" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "annulus tendineus communis" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "anulus tendineus" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "anulus tendineus communis" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "common tendinous ring" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "ligament of Zinn" . [] oboInOwl:hasDbXref "Wikipedia:Annulus_of_Zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014796 ; owl:annotatedTarget "tendon of Zinn" . [] oboInOwl:source "ISBN:0073040584" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget _:genid156802 . [] oboInOwl:source "dbpedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget _:genid156804 . [] oboInOwl:hasDbXref "Wikipedia:Vastus_intermedius_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "The Vastus intermedius (Cruraeus) arises from the front and lateral surfaces of the body of the femur in its upper two-thirds, sitting under Rectus Femoris and from the lower part of the lateral intermuscular septum. Its fibers end in a superficial aponeurosis, which forms the deep part of the Quadriceps femoris tendon. The Vastus medialis and Vastus intermedius appear to be inseparably united, but when the Rectus femoris has been reflected a narrow interval will be observed extending upward from the medial border of the patella between the two muscles, and the separation may be continued as far as the lower part of the intertrochanteric line, where, however, the two muscles are frequently continuous." . [] oboInOwl:source "BTO:0002542" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "Origin: anterior and lateral surfaces of femur; insertion: patella, common tendon of quadriceps femoris; innervation: femoral; action, extends leg[BTO:0002542]." . [] oboInOwl:hasDbXref "Wikipedia:Vastus_intermedius_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "cruraeus" . [] oboInOwl:hasDbXref "BTO:0002542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "crureus" . [] oboInOwl:hasDbXref "BTO:0002542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "intermediate great muscle" . [] oboInOwl:hasDbXref "BTO:0002542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "intermediate vastus muscle" . [] oboInOwl:hasDbXref "BTO:0002542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "musculus vastus intermedius" . [] oboInOwl:hasDbXref "Wikipedia:Vastus_intermedius_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "vastus intermedialis" . [] oboInOwl:hasDbXref "Wikipedia:Vastus_intermedius_muscle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014847 ; owl:annotatedTarget "vastus intermedius" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget obo:UBERON_0000043 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget _:genid156817 . [] oboInOwl:hasDbXref "FMA:46900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget "quadriceps femoris tendon" . [] oboInOwl:hasDbXref "FMA:46900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget "quadriceps tendon" . [] oboInOwl:hasDbXref "FMA:46900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget "common quadriceps femoris tendon" . [] oboInOwl:hasDbXref "FMA:46900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget "common quadriceps tendon" . [] oboInOwl:hasDbXref "FMA:46900" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014848 ; owl:annotatedTarget "common tendon of quadriceps femoris muscle complex" . [] oboInOwl:hasDbXref "FMA:9349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014851 ; owl:annotatedTarget "Chorda tendinea which is attached to the leaflet of mitral valve and is continuous with the endocardium of papillary muscle of left ventricle." . [] oboInOwl:hasDbXref "FMA:9300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014852 ; owl:annotatedTarget "Chorda tendinea which is attached to the leaflet of tricuspid valve and is continuous with the endocardium of papillary muscle of right ventricle." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of pedal digit 1." . [] oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "distal end of distal phalanx of big toe" . [] oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "distal epiphysis of distal phalanx of big toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "distal epiphysis of distal phalanx of pedal digit I" . [] oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "head of distal phalanx of big toe" . [] oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "head of distal phalanx of first digit of foot" . [] oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "head of distal phalanx of great toe" . _:genid154639 oboInOwl:hasDbXref "FMA:33036" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014871 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of big toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001353 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002187 ; owl:annotatedTarget obo:CL_0000646 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of pedal digit 2." . _:genid154645 oboInOwl:hasDbXref "FMA:33045" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "distal end of distal phalanx of second toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001262 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "distal epiphysis of distal phalanx of pedal digit II" . [] oboInOwl:hasDbXref "FMA:33045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "distal epiphysis of distal phalanx of second toe" . [] oboInOwl:hasDbXref "FMA:33045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "head of distal phalanx of second toe" . [] oboInOwl:hasDbXref "FMA:33045" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014872 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of second toe" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002187 ; owl:annotatedTarget "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of pedal digit 3." . [] oboInOwl:hasDbXref "FMA:33054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "distal end of distal phalanx of third toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "distal epiphysis of distal phalanx of pedal digit III" . [] oboInOwl:hasDbXref "FMA:33054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "distal epiphysis of distal phalanx of third toe" . [] oboInOwl:hasDbXref "FMA:33054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "head of distal phalanx of third digit of foot" . [] oboInOwl:hasDbXref "FMA:33054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "head of distal phalanx of third toe" . [] oboInOwl:hasDbXref "FMA:33054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014873 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of third toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of pedal digit 4." . [] oboInOwl:hasDbXref "FMA:33091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "distal end of distal phalanx of fourth toe" . [] oboInOwl:hasDbXref "FMA:33091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "distal epiphysis of distal phalanx of fourth toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "distal epiphysis of distal phalanx of pedal digit IV" . [] oboInOwl:hasDbXref "FMA:33091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "head of distal phalanx of fourth digit of foot" . [] oboInOwl:hasDbXref "FMA:33091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "head of distal phalanx of fourth toe" . [] oboInOwl:hasDbXref "FMA:33091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014874 ; owl:annotatedTarget "ungal tuberosity of distal phalanx of fourth toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of pedal digit 5." . _:genid154677 oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "distal end of distal phalanx of little toe" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001256 . [] oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "distal epiphysis of distal phalanx of little toe" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "distal epiphysis of distal phalanx of pedal digit V" . [] oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "head of distal phalanx of fifth digit of foot" . [] oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "head of distal phalanx of fifth toe" . [] oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "head of distal phalanx of little toe" . [] oboInOwl:hasDbXref "FMA:33106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014875 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of fifth toe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of manual digit 1." . [] oboInOwl:hasDbXref "FMA:37609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "distal end of phalanx of right thumb" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "distal epiphysis of distal phalanx of manual digit I" . [] oboInOwl:hasDbXref "FMA:37609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "distal epiphysis of distal phalanx of thumb" . [] oboInOwl:hasDbXref "FMA:37609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "head of distal phalanx of first digit of hand" . [] oboInOwl:hasDbXref "FMA:37609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "head of distal phalanx of thumb" . [] oboInOwl:hasDbXref "FMA:37609" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014881 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of thumb" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002188 ; owl:annotatedTarget obo:CL_0000115 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of manual digit 2." . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "distal end of distal phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "distal end of distal phalanx of second finger" . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "distal epiphysis of distal phalanx of index finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "distal epiphysis of distal phalanx of manual digit II" . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "head of distal phalanx of index finger" . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "head of distal phalanx of second finger" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15840009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002188 ; owl:annotatedTarget "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." . [] oboInOwl:hasDbXref "FMA:37621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014882 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of index finger" . _:genid154715 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of manual digit 3." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002390 . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "distal end of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "distal end of distal phalanx of third finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "distal epiphysis of distal phalanx of manual digit III" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "distal epiphysis of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "head of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "head of distal phalanx of third digit of hand" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "head of distal phalanx of third finger" . [] oboInOwl:hasDbXref "FMA:37633" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014883 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of middle finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of manual digit 4." . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "distal end of distal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "distal end of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "distal epiphysis of distal phalanx of manual digit IV" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "distal epiphysis of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "head of distal phalanx of fourth digit of hand" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "head of distal phalanx of fourth finger" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "head of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "FMA:37645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014884 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of ring finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx of manual digit 5." . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "distal end of distal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "distal end of distal phalanx of little finger" . _:genid154744 oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "distal epiphysis of distal phalanx of little finger" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0012465 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "distal epiphysis of distal phalanx of manual digit V" . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "head of distal phalanx of fifth digit of hand" . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "head of distal phalanx of fifth finger" . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "head of distal phalanx of little finger" . [] oboInOwl:hasDbXref "FMA:37657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014885 ; owl:annotatedTarget "ungual tuberosity of distal phalanx of little finger" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014887 ; owl:annotatedTarget "A distal epiphysis that is part of a distal phalanx." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002191 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014889 ; owl:annotatedTarget "A cerebellar hemisphere that is in_the_left_side_of a cerebellum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014890 ; owl:annotatedTarget "A cerebellar hemisphere that is in_the_right_side_of a cerebellum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002191 ; owl:annotatedTarget "A cell involved in the formation of a granulocyte." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014891 ; owl:annotatedTarget "White matter that is part of a brainstem [Automatically generated definition]." . [] oboInOwl:hasDbXref "EMAPA:35189" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014891 ; owl:annotatedTarget "brain stem white matter" . _:genid154777 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002103 ; owl:someValuesFrom obo:CL_0000100, obo:UBERON_0001353 . ( ) . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014892 ; owl:annotatedTarget "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." . [] oboInOwl:hasDbXref "ZFA:0005076", "ZFA:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014903 ; owl:annotatedTarget "A portion of tissue that will develop into vasculature." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget obo:UBERON_0001981 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget _:genid157000 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." . [] oboInOwl:source "ZFA:0001285, ZFIN:ZDB-PUB-030908-4" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "Blood vessels that connect the dorsal aorta or the posterior cardinal vein and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these don't have venous or arterial markers[ZFA:0001285, ZFIN:ZDB-PUB-030908-4]." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "EMAPA:37389" . _:genid154798 oboInOwl:hasDbXref "ZFA:0001285" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "intersegmental vessel" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010709 . [] oboInOwl:hasDbXref "ZFA:0001285" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "intersegmental vessels" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Beilstein:635770" . [] oboInOwl:hasDbXref "XAO:0004075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "intersomitic blood vessel" . [] oboInOwl:hasDbXref "ZFA:0001285" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "intersomitic vessels" . [] oboInOwl:hasDbXref "ZFA:0001285" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014907 ; owl:annotatedTarget "segmental vessel" . ( ) . _:genid154810 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0001019 ; owl:someValuesFrom obo:UBERON_0001137, obo:UBERON_0001359 . [] oboInOwl:hasDbXref "DOI:10.1007/s11064-015-1581-6", "ncithesaurus:Perivascular_Space" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0014930 ; owl:annotatedTarget "The space between a blood vessel and the pia mater." . _:genid154812 oboInOwl:hasDbXref "Wikipedia:Virchow-Robin_space" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0014930 ; owl:annotatedTarget "VRS" ; owl:onProperty obo:BSPO_0015101 ; owl:someValuesFrom obo:UBERON_0000974 . [] oboInOwl:hasDbXref "Wikipedia:Virchow-Robin_space" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0014930 ; owl:annotatedTarget "Virchow-Robin space" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0014930 ; owl:annotatedTarget "perivascular spaces" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0014950 ; owl:annotatedTarget _:genid157023 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002194 ; owl:annotatedTarget obo:CL_0000839 . [] oboInOwl:hasDbXref "UBERON:mah", "https://github.com/obophenotype/uberon/issues/70" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015001 ; owl:annotatedTarget "The major preaxial endrochondral skeletal element in the anterior zeugopod." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015001 ; owl:annotatedTarget "radius skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015001 ; owl:annotatedTarget "radius element" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002194 ; owl:annotatedTarget "A cell involved in the formation of a monocyte (monopoiesis)." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015002 ; owl:annotatedTarget "A radius-ulna bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015002 ; owl:annotatedTarget "radius-ulna skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015002 ; owl:annotatedTarget "radius-ulna element" . [] oboInOwl:hasDbXref "UBERON:mah", "https://github.com/obophenotype/uberon/issues/70" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015003 ; owl:annotatedTarget "Major postaxial endrochondral skeletal element in the anterior zeugopod." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015003 ; owl:annotatedTarget "ulna skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015003 ; owl:annotatedTarget "ulna element" . [] oboInOwl:hasDbXref "PHENOSCAPE:mah", "https://github.com/obophenotype/uberon/issues/71" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015004 ; owl:annotatedTarget "The major preaxial endochondral element in the posterior zeugopod[Phenoscape]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015004 ; owl:annotatedTarget "tibia skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015004 ; owl:annotatedTarget "tibia element" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015007 ; owl:annotatedTarget "A vertebral endochondral element in the cervical region of the vertebral column." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015007 ; owl:annotatedTarget "cervical vertebra skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015007 ; owl:annotatedTarget "cervical vertebra element" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015008 ; owl:annotatedTarget "A vertebral endochondral element in the thoracic region of the vertebral column." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015008 ; owl:annotatedTarget "thoracic vertebra skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015008 ; owl:annotatedTarget "thoracic vertebra element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015009 ; owl:annotatedTarget "A lumbar vertebra bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015009 ; owl:annotatedTarget "lumbar vertebra skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015009 ; owl:annotatedTarget "lumbar vertebra element" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:26798363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015010 ; owl:annotatedTarget "A vertebra endochondral element that is part of the sacral region of the vertebral column." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015010 ; owl:annotatedTarget "sacral vertebra skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015010 ; owl:annotatedTarget "sacral vertebra element" . [] oboInOwl:hasDbXref "PHENOSCAPE:mah", "https://github.com/obophenotype/uberon/issues/73" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015013 ; owl:annotatedTarget "The major postaxial endochondral element in the posterior zeugopod[Phenoscape]." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015013 ; owl:annotatedTarget "fibula skeletal element" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "CAS:79-31-2" . [] oboInOwl:hasDbXref "PMID:18442648" ; oboInOwl:hasSynonymType cl:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002195 ; owl:annotatedTarget "HpSC" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015013 ; owl:annotatedTarget "fibula element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015014 ; owl:annotatedTarget "A calcaneum bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015014 ; owl:annotatedTarget "calcaneum skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015014 ; owl:annotatedTarget "calcaneum element" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002198 ; owl:annotatedTarget "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015016 ; owl:annotatedTarget "A stapes bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015016 ; owl:annotatedTarget "stapes skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015016 ; owl:annotatedTarget "stapes element" . [] oboInOwl:hasDbXref "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002199 ; owl:annotatedTarget "An oncocyte located in the parathyroid gland." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015017 ; owl:annotatedTarget "An incus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015017 ; owl:annotatedTarget "incus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015017 ; owl:annotatedTarget "incus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015018 ; owl:annotatedTarget "A malleus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015018 ; owl:annotatedTarget "malleus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015018 ; owl:annotatedTarget "malleus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015018 ; owl:annotatedTarget "malleus" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015019 ; owl:annotatedTarget "A rib bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015019 ; owl:annotatedTarget "rib skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015019 ; owl:annotatedTarget "rib element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015021 ; owl:annotatedTarget "A forelimb bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015021 ; owl:annotatedTarget "forelimb skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015022 ; owl:annotatedTarget "A hindlimb bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015022 ; owl:annotatedTarget "hindlimb bone skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015023 ; owl:annotatedTarget "A phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015023 ; owl:annotatedTarget "phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015023 ; owl:annotatedTarget "phalanx element" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20013317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002200 ; owl:annotatedTarget "An oncocyte located in the thyroid." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015024 ; owl:annotatedTarget "A manual digit phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015024 ; owl:annotatedTarget "manual digit phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015024 ; owl:annotatedTarget "manual digit phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015025 ; owl:annotatedTarget "A manual digit 1 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015025 ; owl:annotatedTarget "manual digit 1 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015025 ; owl:annotatedTarget "manual digit 1 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015025 ; owl:annotatedTarget "manual digit I phalanx endochondral element" . _:genid154996 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003622 ] ) ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001653 . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "CAS:79-31-2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015026 ; owl:annotatedTarget "A manual digit 2 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015026 ; owl:annotatedTarget "manual digit 2 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015026 ; owl:annotatedTarget "manual digit 2 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015026 ; owl:annotatedTarget "manual digit II phalanx endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015027 ; owl:annotatedTarget "A manual digit 3 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015027 ; owl:annotatedTarget "manual digit 3 phalanx skeletal element" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002202 ; owl:annotatedTarget "An epithelial cell of the tracheobronchial tree." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015027 ; owl:annotatedTarget "manual digit 3 phalanx element" . _:genid155021 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015027 ; owl:annotatedTarget "manual digit III phalanx endochondral element" ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002209 ; owl:annotatedTarget "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." . _:genid155030 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001544, obo:UBERON_5103624 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015028 ; owl:annotatedTarget "A manual digit 4 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015028 ; owl:annotatedTarget "manual digit 4 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015028 ; owl:annotatedTarget "manual digit 4 phalanx element" . _:genid155034 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015028 ; owl:annotatedTarget "manual digit IV phalanx endochondral element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009616 . _:genid155037 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001891, obo:UBERON_0003625 . _:genid155039 a owl:Class, owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0013147 ; owl:unionOf (obo:UBERON_0003639 obo:UBERON_0010579 obo:UBERON_0010679 ) . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002220 ; owl:annotatedTarget "A cell located between the pinealocytes." . (obo:UBERON_0010679 ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015029 ; owl:annotatedTarget "A manual digit 5 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015029 ; owl:annotatedTarget "manual digit 5 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015029 ; owl:annotatedTarget "manual digit 5 phalanx element" . _:genid155047 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015029 ; owl:annotatedTarget "manual digit V phalanx endochondral element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005281 . _:genid155057 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007237, obo:UBERON_5101466 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015030 ; owl:annotatedTarget "A pedal digit phalanx bone or its cartilage or pre-cartilage precursor." . _:genid155059 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015030 ; owl:annotatedTarget "pedal digit phalanx skeletal element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009722 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002222 ; owl:annotatedTarget "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015030 ; owl:annotatedTarget "pedal digit phalanx element" . _:genid155061 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015023 _:genid155063 ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007122 . _:genid155063 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003631, obo:UBERON_0007690 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015031 ; owl:annotatedTarget "A pedal digit 1 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015031 ; owl:annotatedTarget "pedal digit 1 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015031 ; owl:annotatedTarget "pedal digit 1 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015031 ; owl:annotatedTarget "pedal digit I phalanx endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015032 ; owl:annotatedTarget "A pedal digit 2 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015032 ; owl:annotatedTarget "pedal digit 2 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015032 ; owl:annotatedTarget "pedal digit 2 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015032 ; owl:annotatedTarget "pedal digit II phalanx endochondral element" . _:genid155087 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015023 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003633 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002812 . (obo:UBERON_0010682 ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015033 ; owl:annotatedTarget "A pedal digit 3 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015033 ; owl:annotatedTarget "pedal digit 3 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015033 ; owl:annotatedTarget "pedal digit 3 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015033 ; owl:annotatedTarget "pedal digit III phalanx endochondral element" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "CAS:79-31-2" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015034 ; owl:annotatedTarget "A pedal digit 4 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002224 ; owl:annotatedTarget obo:CL_0000075 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015034 ; owl:annotatedTarget "pedal digit 4 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015034 ; owl:annotatedTarget "pedal digit 4 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015034 ; owl:annotatedTarget "pedal digit IV phalanx endochondral element" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002224 ; owl:annotatedTarget "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015035 ; owl:annotatedTarget "A pedal digit 5 phalanx bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015035 ; owl:annotatedTarget "pedal digit 5 phalanx skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015035 ; owl:annotatedTarget "pedal digit 5 phalanx element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015035 ; owl:annotatedTarget "pedal digit V phalanx endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015036 ; owl:annotatedTarget "A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015036 ; owl:annotatedTarget "pedal digit metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015036 ; owl:annotatedTarget "pedal digit metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015037 ; owl:annotatedTarget "A pedal digit 1 metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015037 ; owl:annotatedTarget "pedal digit 1 metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015037 ; owl:annotatedTarget "pedal digit 1 metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015037 ; owl:annotatedTarget "pedal digit I metatarsal endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015038 ; owl:annotatedTarget "A pedal digit 2 metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015038 ; owl:annotatedTarget "pedal digit 2 metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015038 ; owl:annotatedTarget "pedal digit 2 metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015038 ; owl:annotatedTarget "pedal digit II metatarsal endochondral element" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002231 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015039 ; owl:annotatedTarget "A pedal digit 3 metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015039 ; owl:annotatedTarget "pedal digit 3 metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015039 ; owl:annotatedTarget "pedal digit 3 metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015039 ; owl:annotatedTarget "pedal digit III metatarsal endochondral element" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002231 ; owl:annotatedTarget "An epithelial cell of the prostate." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015040 ; owl:annotatedTarget "A pedal digit 4 metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015040 ; owl:annotatedTarget "pedal digit 4 metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015040 ; owl:annotatedTarget "pedal digit 4 metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015040 ; owl:annotatedTarget "pedal digit IV metatarsal endochondral element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015041 ; owl:annotatedTarget "A pedal digit 5 metatarsal bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015041 ; owl:annotatedTarget "pedal digit 5 metatarsal skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015041 ; owl:annotatedTarget "pedal digit 5 metatarsal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015041 ; owl:annotatedTarget "pedal digit V metatarsal endochondral element" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Gmelin:49630" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015042 ; owl:annotatedTarget "A manual digit metacarpus bone or its cartilage or pre-cartilage precursor." . _:genid155208 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015042 ; owl:annotatedTarget "manual digit metacarpus skeletal element" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006261 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015042 ; owl:annotatedTarget "manual digit metacarpus element" . (obo:UBERON_0003645 obo:UBERON_0010565 obo:UBERON_0010570 ) . _:genid155218 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015043 ; owl:annotatedTarget "A manual digit 1 metacarpus bone or its cartilage or pre-cartilage precursor." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004876 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015043 ; owl:annotatedTarget "manual digit 1 metacarpus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015043 ; owl:annotatedTarget "manual digit 1 metacarpus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015043 ; owl:annotatedTarget "manual digit I metacarpus endochondral element" . (obo:UBERON_0010571 ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015044 ; owl:annotatedTarget "A manual digit 2 metacarpus bone or its cartilage or pre-cartilage precursor." . _:genid155231 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015044 ; owl:annotatedTarget "manual digit 2 metacarpus skeletal element" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003890 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015044 ; owl:annotatedTarget "manual digit 2 metacarpus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015044 ; owl:annotatedTarget "manual digit II metacarpus endochondral element" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget "An epithelial cell of prostatic duct." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015045 ; owl:annotatedTarget "A manual digit 3 metacarpus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015045 ; owl:annotatedTarget "manual digit 3 metacarpus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015045 ; owl:annotatedTarget "manual digit 3 metacarpus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015045 ; owl:annotatedTarget "manual digit III metacarpus endochondral element" . [] oboInOwl:hasDbXref "FMA:74224" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002232 ; owl:annotatedTarget "ductal epithelial cell of prostate" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015046 ; owl:annotatedTarget "A manual digit 4 metacarpus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015046 ; owl:annotatedTarget "manual digit 4 metacarpus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015046 ; owl:annotatedTarget "manual digit 4 metacarpus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015046 ; owl:annotatedTarget "manual digit IV metacarpus endochondral element" . (obo:UBERON_0003649 obo:UBERON_0010569 obo:UBERON_0010574 ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015047 ; owl:annotatedTarget "A manual digit 5 metacarpus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015047 ; owl:annotatedTarget "manual digit 5 metacarpus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015047 ; owl:annotatedTarget "manual digit 5 metacarpus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015047 ; owl:annotatedTarget "manual digit V metacarpus endochondral element" . (obo:UBERON_0006214 ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015049 ; owl:annotatedTarget "A carpus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015049 ; owl:annotatedTarget "carpus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015049 ; owl:annotatedTarget "carpus element" . (obo:UBERON_0010540 obo:UBERON_0010541 ) . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015050 ; owl:annotatedTarget "A tarsus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015050 ; owl:annotatedTarget "tarsus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015050 ; owl:annotatedTarget "tarsus element" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01020071" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15226377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002236 ; owl:annotatedTarget "A cell that constitutes the basal layer of epithelium in the prostatic duct." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015052 ; owl:annotatedTarget "A femur bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015052 ; owl:annotatedTarget "femur skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015052 ; owl:annotatedTarget "femur element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015053 ; owl:annotatedTarget "A humerus bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015053 ; owl:annotatedTarget "humerus skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015053 ; owl:annotatedTarget "humerus element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015054 ; owl:annotatedTarget "An iliac bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015054 ; owl:annotatedTarget "iliac skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015054 ; owl:annotatedTarget "iliac element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015055 ; owl:annotatedTarget "A pubic bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015055 ; owl:annotatedTarget "pubic skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015055 ; owl:annotatedTarget "pubic element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015056 ; owl:annotatedTarget "An ischial bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015056 ; owl:annotatedTarget "ischial skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015056 ; owl:annotatedTarget "ischial element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015057 ; owl:annotatedTarget "A scapula bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015057 ; owl:annotatedTarget "scapula skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015057 ; owl:annotatedTarget "scapula element" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002240 ; owl:annotatedTarget "A fibroblast in the bone marrow." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015059 ; owl:annotatedTarget "An orbitosphenoid bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015059 ; owl:annotatedTarget "orbitosphenoid skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015059 ; owl:annotatedTarget "orbitosphenoid element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015060 ; owl:annotatedTarget "A sphenoid bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015060 ; owl:annotatedTarget "sphenoid bone skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015060 ; owl:annotatedTarget "sphenoid element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015061 ; owl:annotatedTarget "A limb bone or its cartilage or pre-cartilage precursor." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0015061 ; owl:annotatedTarget "limb bone skeletal element" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015061 ; owl:annotatedTarget "limb bone endochondral element" . [] oboInOwl:source "cjm" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015063 ; owl:annotatedTarget _:genid157585 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015063 ; owl:annotatedTarget "An endochondral element that is part of a autopod region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015064 ; owl:annotatedTarget "An autopod endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "PHENOSCAPE:AMAO" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015067 ; owl:annotatedTarget "Endochondral element located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE]." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0015067 ; owl:annotatedTarget "the FMA term is under 'general anatomical term'." . [] oboInOwl:hasDbXref "UBERON:0012131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015067 ; owl:annotatedTarget "central mesopodium element" . [] oboInOwl:hasDbXref "UBERON:0012131" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015067 ; owl:annotatedTarget "centralia" . [] oboInOwl:source "skeleton pattern" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015068 ; owl:annotatedTarget _:genid157602 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015068 ; owl:annotatedTarget "A distal mesopodial endochondral element that is part of a forelimb." . [] oboInOwl:hasDbXref "AAO:0000847", "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015068 ; owl:annotatedTarget "distal carpal" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "PMID:10757489" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015069 ; owl:annotatedTarget "A distal carpal endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015077 ; owl:annotatedTarget "A centrale endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015078 ; owl:annotatedTarget "A proximal mesopodial endochondral element that is part of a forelimb." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015078 ; owl:annotatedTarget "proximal carpal element" . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015078 ; owl:annotatedTarget "proximal carpal" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002241 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015079 ; owl:annotatedTarget "A proximal carpal endochondral element that is composed primarily of cartilage tissue." . _:genid155421 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015078 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0005866 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011565 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015080 ; owl:annotatedTarget "A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002241 ; owl:annotatedTarget "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." . _:genid155432 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015081 ; owl:annotatedTarget "A proximal mesopodial endochondral element that is part of a hindlimb." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003051 . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015081 ; owl:annotatedTarget "proximal tarsal" . _:genid155434 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015081 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006273 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015082 ; owl:annotatedTarget "A proximal tarsal endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015083 ; owl:annotatedTarget "A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015084 ; owl:annotatedTarget "distal carpal 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015085 ; owl:annotatedTarget "A distal carpal bone 1 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015086 ; owl:annotatedTarget "A distal carpal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015087 ; owl:annotatedTarget "distal carpal 2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015088 ; owl:annotatedTarget "A distal carpal bone 2 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015089 ; owl:annotatedTarget "A distal carpal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015090 ; owl:annotatedTarget "distal carpal 3" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002242 ; owl:annotatedTarget "A cell containing at least one nucleus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015091 ; owl:annotatedTarget "A distal carpal bone 3 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015092 ; owl:annotatedTarget "A distal carpal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015093 ; owl:annotatedTarget "distal carpal 4" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015094 ; owl:annotatedTarget "A distal carpal bone 4 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "PMID:17580301" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015095 ; owl:annotatedTarget "A distal carpal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "skeleton pattern" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015099 ; owl:annotatedTarget _:genid157720 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015099 ; owl:annotatedTarget "A distal mesopodial endochondral element that is part of a hindlimb." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015099 ; owl:annotatedTarget "distal tarsal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015100 ; owl:annotatedTarget "A distal tarsal endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015101 ; owl:annotatedTarget "A distal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015102 ; owl:annotatedTarget "distal tarsal 1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015103 ; owl:annotatedTarget "A distal tarsal bone 1 endochondral element that is composed primarily of cartilage tissue." . _:genid155534 oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015103 ; owl:annotatedTarget "distal tarsal 1 cartilage" ; owl:onProperty obo:RO_0002226 ; owl:someValuesFrom obo:UBERON_0007846 . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015103 ; owl:annotatedTarget "distal tarsal 1 cartilage element" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget obo:CL_0000358 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015104 ; owl:annotatedTarget "A distal tarsal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015105 ; owl:annotatedTarget "distal tarsal 2" . _:genid155549 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015106 ; owl:annotatedTarget "A distal tarsal bone 2 endochondral element that is composed primarily of cartilage tissue." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001902 . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544", "ISBN:0721694128" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002243 ; owl:annotatedTarget "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015106 ; owl:annotatedTarget "distal tarsal 2 cartilage" . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015106 ; owl:annotatedTarget "distal tarsal 2 cartilage element" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015107 ; owl:annotatedTarget "A distal tarsal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015108 ; owl:annotatedTarget "distal tarsal 3" . ( ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015109 ; owl:annotatedTarget "A distal tarsal bone 3 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015110 ; owl:annotatedTarget "A distal tarsal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015111 ; owl:annotatedTarget "distal tarsal 4" . _:genid155573 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015111 [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0013646 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015112 ; owl:annotatedTarget "A distal tarsal bone 4 endochondral element that is composed primarily of cartilage tissue." . _:genid155585 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015113 ; owl:annotatedTarget "A distal tarsal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation." ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015114 ; owl:annotatedTarget "distal tarsal 5" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015115 ; owl:annotatedTarget "A distal tarsal bone 5 endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015116 ; owl:annotatedTarget "A distal tarsal bone 5 endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "PMID:17877388" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002246 ; owl:annotatedTarget obo:CL_0000037 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015120 ; owl:annotatedTarget "An outer canthus that is in_the_right_side_of a head." . [] oboInOwl:hasDbXref "FMA:59317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015120 ; owl:annotatedTarget "right lateral palpebral commissure" . [] oboInOwl:hasDbXref "FMA:59317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015120 ; owl:annotatedTarget "lateral angle of right eye" . [] oboInOwl:hasDbXref "FMA:59317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015120 ; owl:annotatedTarget "lateral canthus of right eye" . [] oboInOwl:hasDbXref "FMA:59317" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015120 ; owl:annotatedTarget "right lateral canthus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002246 ; owl:annotatedTarget "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015121 ; owl:annotatedTarget "An outer canthus that is in_the_left_side_of a head." . [] oboInOwl:hasDbXref "FMA:59318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015121 ; owl:annotatedTarget "left lateral palpebral commissure" . [] oboInOwl:hasDbXref "FMA:59318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015121 ; owl:annotatedTarget "lateral angle of left eye" . [] oboInOwl:hasDbXref "FMA:59318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015121 ; owl:annotatedTarget "lateral canthus of left eye" . [] oboInOwl:hasDbXref "FMA:59318" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015121 ; owl:annotatedTarget "left lateral canthus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015122 ; owl:annotatedTarget "An anatomical line of the face that connects the two outer (lateral) canthi of the eye. The length of this line is known as the outer canthal distance." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015128 ; owl:annotatedTarget obo:UBERON_0001136 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015128 ; owl:annotatedTarget _:genid157839 . [] oboInOwl:hasDbXref "FMA:83105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015128 ; owl:annotatedTarget "perimysial connective tissue of subepicardium" . [] oboInOwl:hasDbXref "FMA:83105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015128 ; owl:annotatedTarget "subepicardial connective tissue" . [] oboInOwl:hasDbXref "DOI:10.5935/abc.20130138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015129 ; owl:annotatedTarget "Visceral intrapericardial fat contiguous with the myocardial surface." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015130 ; owl:annotatedTarget obo:UBERON_0011822 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015130 ; owl:annotatedTarget "A portion of connective tissue that is part of a prostate gland." . [] oboInOwl:hasDbXref "FMA:74165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015130 ; owl:annotatedTarget "connective tissue of prostate" . [] oboInOwl:hasDbXref "MURDOCH:768" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015142 ; owl:annotatedTarget "A large fat pad that is located at the base of the abdominal wall, in the falciform ligament of the liver." . [] oboInOwl:hasDbXref "MP:0008903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015143 ; owl:annotatedTarget "Encapsulated adipose tissue associated with the mesentery." . [] oboInOwl:hasDbXref "MP:0008903" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015143 ; owl:annotatedTarget "mesenteric fat depot" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002251 ; owl:annotatedTarget "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." . (obo:UBERON_0001037 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002470 ] ) . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015144 ; owl:annotatedTarget "A strand of hair that is part of a autopod region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015145 ; owl:annotatedTarget "A strand of hair that is part of a pes." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015146 ; owl:annotatedTarget "A strand of hair that is part of a manus." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015147 ; owl:annotatedTarget "A strand of hair that is part of a pinna." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015148 ; owl:annotatedTarget "A strand of hair that is part of a tail." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015148 ; owl:annotatedTarget "EMAPA:37971" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015149 ; owl:annotatedTarget "A strand of hair that is part of a ventrum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015150 ; owl:annotatedTarget "A strand of hair that is part of a dorsum." . [] oboInOwl:hasDbXref "FMA:54320" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015150 ; owl:annotatedTarget "hair of back" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Reaxys:635770" . [] oboInOwl:source "inferred" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015152 ; owl:annotatedTarget _:genid157913 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015152 ; owl:annotatedTarget "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015154 ; owl:annotatedTarget "A gland that is located in or around the ocular region, nearer the outer canthi." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015155 ; owl:annotatedTarget _:genid157921 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015155 ; owl:annotatedTarget "An anatomical space that is enclosed by a conjunctiva." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002252 ; owl:annotatedTarget obo:CL_0002251 . [] oboInOwl:hasDbXref "FMA:59083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015155 ; owl:annotatedTarget "cavity of conjunctival sac" . [] oboInOwl:hasDbXref "FMA:59083" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015155 ; owl:annotatedTarget "conjunctival sac cavity" . [] oboInOwl:hasDbXref "NCBITaxon:8570", "PMID:7559104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0015155 ; owl:annotatedTarget "subbrillar space" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nasal_artery", "Wikipedia:Supratrochlear_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015156 ; owl:annotatedTarget "The two terminal branches of the ophthalmic artery in humans are the dorsal nasal artery and the supratrochlear artery." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002252 ; owl:annotatedTarget "An epithelial cell of the esophagus." . [] oboInOwl:source "AAO", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget _:genid157935 . [] oboInOwl:hasDbXref "Wikipedia:Inferior_branch_of_oculomotor_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "The inferior branch of the oculomotor nerve or the inferior division, the larger, divides into three branches. One passes beneath the optic nerve to the medial rectus. Another, to the inferior rectus. The third and longest runs forward between the inferior recti and lateralis to the inferior oblique. From the last a short thick branch is given off to the lower part of the ciliary ganglion, and forms its short root. All these branches enter the muscles on their ocular surfaces, with the exception of the nerve to the inferior oblique, which enters the muscle at its posterior border." . [] oboInOwl:hasDbXref "FMA:52573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "inferior ramus of oculomotor nerve" . [] oboInOwl:hasDbXref "FMA:52573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "oculomotor nerve inferior division" . [] oboInOwl:hasDbXref "FMA:52573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "ramus inferior (nervus oculomotorius [III])" . [] oboInOwl:hasDbXref "Wikipedia:Inferior_branch_of_oculomotor_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "ramus inferior nervi oculomotorii" . [] oboInOwl:hasDbXref "FMA:52573", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "ramus inferior nervus oculomotorii" . [] oboInOwl:hasDbXref "FMA:52573" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "inferior division of oculomotor nerve" . [] oboInOwl:hasDbXref "AAO:0010632" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "ventral ramus of occulomotor nerve" . [] oboInOwl:hasDbXref "AAO:0010632" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015161 ; owl:annotatedTarget "ventral ramus of oculomotor nerve" . [] oboInOwl:hasDbXref "PMID:21062451", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015165 ; owl:annotatedTarget "An eye consisting of multiple light-sensing organs." . [] oboInOwl:notes "The eyes (optic cushions) on the oral surface of Asteroida (Echinodermata), close to the base of the terminal tentacles, are also composed of a number of simple ocelli - as many as 80-200 in certain species" ; oboInOwl:source "PMID:21062451" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0015165 ; owl:annotatedTarget obo:NCBITaxon_7588 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015172 ; owl:annotatedTarget "A blood vessel that is part of a endometrium." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015178 ; owl:annotatedTarget "A region of somite adjacent to presomitic mesoderm." . [] oboInOwl:hasDbXref "XAO:0004074" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015178 ; owl:annotatedTarget "intersomitic junction" . [] oboInOwl:hasDbXref "ZFA:0001462" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015178 ; owl:annotatedTarget "somite boundary" . [] oboInOwl:hasDbXref "XAO:0004077", "XAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015179 ; owl:annotatedTarget "Epithelium located in the intersomitic region." . [] oboInOwl:hasDbXref "XAO:0004077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015179 ; owl:annotatedTarget "intersomitic epithelium" . [] oboInOwl:hasDbXref "XAO:0004077" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015179 ; owl:annotatedTarget "intersomitic membrane" . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_talus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015180 ; owl:annotatedTarget "The neck of talus is directed forward and medialward, and comprises the constricted portion of the bone between the body and the oval head. Its upper and medial surfaces are rough, for the attachment of ligaments; its lateral surface is concave and is continuous below with the deep groove for the interosseous talocalcaneal ligament." . [] oboInOwl:hasDbXref "FMA:33636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015180 ; owl:annotatedTarget "talar neck" . [] oboInOwl:hasDbXref "FMA:33636" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015180 ; owl:annotatedTarget "talus neck" . [] oboInOwl:hasDbXref "Wikipedia:Neck_of_talus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015180 ; owl:annotatedTarget "collum tali" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002253 ; owl:annotatedTarget obo:CL_0002563 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "The slightly constricted part of a tooth, between the crown and the root." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "cervix dentis" . [] oboInOwl:hasDbXref "FMA:55627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "cervix of tooth" . [] oboInOwl:hasDbXref "ncithesaurus:Collum_Dentis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "collumn dentis" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "dental neck" . [] oboInOwl:hasDbXref "FMA:55627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "tooth neck" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "cervical margin of tooth" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015181 ; owl:annotatedTarget "cervical zone of tooth" . [] oboInOwl:hasDbXref "AEO:0000093", "AEO:JB", "FBC:DOS", "FBbt:00007278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015203 ; owl:annotatedTarget "An anatomical group whose component structures share a common function." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002253 ; owl:annotatedTarget "An epithelial cell of the large intestine." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015204 ; owl:annotatedTarget "A non-connected functional system that is composed primarily of a gland." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015212 ; owl:annotatedTarget "Any structure that is placed on one side of the left-right axis of a bilaterian." . _:genid155793 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015214 ; owl:annotatedTarget "A ligament that is part of a diaphragm." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001010 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015228 ; owl:annotatedTarget "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "UM-BBD_compID:c0383" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015233 ; owl:annotatedTarget "A nucleus of brain that is part of a dorsal thalamus." . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015238 ; owl:annotatedTarget _:genid158017 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015238 ; owl:annotatedTarget "A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015249 ; owl:annotatedTarget "A zone of skin that is part of a digit [Automatically generated definition]." . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015251 ; owl:annotatedTarget obo:UBERON_0001821 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015251 ; owl:annotatedTarget "EMAPA:37680" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015280 ; owl:annotatedTarget "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015280 ; owl:annotatedTarget "EMAPA:37711" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015281 ; owl:annotatedTarget "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015281 ; owl:annotatedTarget "EMAPA:37712" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015329 ; owl:annotatedTarget _:genid158043 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015329 ; owl:annotatedTarget "A basement membrane of epithelium that is part of a respiratory system." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015329 ; owl:annotatedTarget "EMAPA:37570" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002254 ; owl:annotatedTarget obo:CL_0002563 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015410 ; owl:annotatedTarget obo:UBERON_0005178 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015410 ; owl:annotatedTarget "EMAPA:37597" . [] oboInOwl:hasDbXref "MA:0002449" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015410 ; owl:annotatedTarget "heart/pericardium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015418 ; owl:annotatedTarget "A mesenchyme that is part of a urethra." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015418 ; owl:annotatedTarget "EMAPA:37786" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002254 ; owl:annotatedTarget "An epithelial cell of the small intestine." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015420 ; owl:annotatedTarget "A valve that is part of a ureter." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015420 ; owl:annotatedTarget "EMAPA:37781" . [] oboInOwl:hasDbXref "MA:0002658" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015420 ; owl:annotatedTarget "ureteral valve" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015453 ; owl:annotatedTarget "A lymph node that is part of a hypodermis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015454 ; owl:annotatedTarget "A fat pad that is part of a pancreas." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015458 ; owl:annotatedTarget "A fat pad that is part of a mediastinum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015474 ; owl:annotatedTarget "A zone of skin that is part of a axilla." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015474 ; owl:annotatedTarget "EMAPA:37349" . [] oboInOwl:hasDbXref "FMA:37322" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015474 ; owl:annotatedTarget "axillary skin" . [] oboInOwl:hasDbXref "FMA:37322" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015474 ; owl:annotatedTarget "skin of axilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015476 ; owl:annotatedTarget "A zone of skin that is part of a external nose." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015476 ; owl:annotatedTarget "EMAPA:37684" . [] oboInOwl:hasDbXref "FMA:24763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015476 ; owl:annotatedTarget "external nasal skin" . [] oboInOwl:hasDbXref "FMA:24763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015476 ; owl:annotatedTarget "skin of external nose" . [] oboInOwl:hasDbXref "FMA:24763" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015476 ; owl:annotatedTarget "skin of nose" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015477 ; owl:annotatedTarget "A fat pad that is part of a axilla." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015479 ; owl:annotatedTarget "A zone of skin that is part of a scrotum." . [] oboInOwl:hasDbXref "FMA:20432" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015479 ; owl:annotatedTarget "skin of scrotum" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget obo:UBERON_0001193 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget _:genid158109 . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_artery_proper" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget "EMAPA:37217" . [] oboInOwl:hasDbXref "FMA:14772" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget "hepatic artery proper" . [] oboInOwl:hasDbXref "Wikipedia:Hepatic_artery_proper" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015480 ; owl:annotatedTarget "proper hepatic" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2-methylpropanoic acid" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget _:genid158119 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget "A hepatic artery that is part of a left lobe of liver." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget "EMAPA:37096" . [] oboInOwl:hasDbXref "FMA:14779" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget "left branch of hepatic artery" . [] oboInOwl:hasDbXref "FMA:14779" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget "left part of hepatic artery proper" . [] oboInOwl:hasDbXref "FMA:14779", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015481 ; owl:annotatedTarget "ramus sinister (arteria hepatica propria)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002255 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget _:genid158131 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget "A hepatic artery that is part of a right lobe of liver." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget "EMAPA:37376" . [] oboInOwl:hasDbXref "FMA:14778", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget "ramus dexter (arteria hepatica propria)" . [] oboInOwl:hasDbXref "FMA:14778" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget "right branch of hepatic artery proper" . [] oboInOwl:hasDbXref "FMA:14778" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015482 ; owl:annotatedTarget "right part of hepatic artery proper" . [] oboInOwl:hasDbXref "PMID:11331626", "PMID:30013421", "PMID:30309298", "Wiki:Decidualization&oldid=908981933#Endometrial_stromal_cells_(ESCs)", "https://doi.org/10.1038/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002255 ; owl:annotatedTarget "A stromal cell of the endometrium that is fibroblastic in appearance. During decidualization this cell may differentiate into a decidual stromal cell." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015485 ; owl:annotatedTarget "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015485 ; owl:annotatedTarget "EMAPA:37478" . [] oboInOwl:hasDbXref "MA:0003108" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015485 ; owl:annotatedTarget "choledochoduodenal junction" . [] oboInOwl:hasDbXref "PMID:30309298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002255 ; owl:annotatedTarget "endometrial stromal fibroblast" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015593 ; owl:annotatedTarget "A gyrus that is part of a frontal cortex." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015716 ; owl:annotatedTarget "An epithelium that is part of a anal canal." . [] oboInOwl:hasDbXref "FMA:17511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015716 ; owl:annotatedTarget "anal canal epithelium" . [] oboInOwl:hasDbXref "FMA:17511" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015716 ; owl:annotatedTarget "epithelium of anal canal" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015717 ; owl:annotatedTarget "A smooth muscle tissue that is part of a ejaculatory duct." . [] oboInOwl:hasDbXref "FMA:19372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015717 ; owl:annotatedTarget "muscle layer of ejaculatory duct" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015751 ; owl:annotatedTarget "A smooth muscle tissue that is part of a inferior eyelid tarsus." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015757 ; owl:annotatedTarget obo:UBERON_0000479 . [] oboInOwl:hasDbXref "FMA:62798" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015757 ; owl:annotatedTarget "portion of heterogeneous tissue" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015766 ; owl:annotatedTarget obo:UBERON_0010371 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015766 ; owl:annotatedTarget "An epithelium that is part of a duct of salivary gland." . _:genid155959 oboInOwl:hasDbXref "FMA:67682" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015766 ; owl:annotatedTarget "epithelium of salivary duct" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001519 . [] oboInOwl:hasDbXref "FMA:67682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015766 ; owl:annotatedTarget "salivary duct epithelium" . [] oboInOwl:hasDbXref "FMA:67682" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015766 ; owl:annotatedTarget "salivary ductal epithelium" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015783 ; owl:annotatedTarget "A smooth muscle tissue that is part of a hypodermis." . [] oboInOwl:hasDbXref "FMA:77862" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015783 ; owl:annotatedTarget "muscle layer in fatty layer of subcutaneous tissue" . [] oboInOwl:hasDbXref "FMA:77862", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015783 ; owl:annotatedTarget "stratum musculosum panniculi adiposi telae subcutaneae" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015787 ; owl:annotatedTarget "Any anatomical conduit which is part of the upper respiratory tract." . [] oboInOwl:source "FMA:265132" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0015787 ; owl:annotatedTarget "Anatomical cluster which consists a segment of the upper respiratory tract[FMA:265132]." . [] oboInOwl:hasDbXref "FMA:265132" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015787 ; owl:annotatedTarget "respiratory conduit" . _:genid155976 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002254 ; owl:someValuesFrom obo:UBERON_0000004, obo:UBERON_0003850 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015788 ; owl:annotatedTarget "An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." . [] oboInOwl:hasDbXref "MA:0000579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015789 ; owl:annotatedTarget "cranial/facial muscle" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002257 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015789 ; owl:annotatedTarget "cranial-facial muscle" . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015789 ; owl:annotatedTarget "cranio-facial muscle" . [] oboInOwl:hasDbXref "EMAPA:25133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015789 ; owl:annotatedTarget "craniofacial muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015790 ; owl:annotatedTarget "A zone of skin that is part of a autopod region." . [] oboInOwl:hasDbXref "MA:0003120" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015790 ; owl:annotatedTarget "paw skin" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002257 ; owl:annotatedTarget "An epithelial cell of thyroid gland." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015791 ; owl:annotatedTarget "A portion of connective tissue that is part of a digit." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015791 ; owl:annotatedTarget "EMAPA:37290" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "ISOBUTYRIC ACID" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0517223651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002258 ; owl:annotatedTarget "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015796 ; owl:annotatedTarget "A blood vessel that is part of a liver." . [] oboInOwl:hasDbXref "EMAPA:35498" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015796 ; owl:annotatedTarget "hepatic blood vessel" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015807 ; owl:annotatedTarget "An epithelium that is part of a ear." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015808 ; owl:annotatedTarget "An epithelium that is part of a camera-type eye." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015813 ; owl:annotatedTarget "An epithelium that is part of a middle ear." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015814 ; owl:annotatedTarget "An epithelium that is part of a external ear." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015833 ; owl:annotatedTarget "An epithelium that is part of a foregut." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015834 ; owl:annotatedTarget _:genid158252 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015834 ; owl:annotatedTarget "A lamina propria that is part of a duodenum." . [] oboInOwl:hasDbXref "FMA:15972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015834 ; owl:annotatedTarget "duodenal lamina propria" . [] oboInOwl:hasDbXref "FMA:15972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015834 ; owl:annotatedTarget "lamina propria mucosae of duodenum" . [] oboInOwl:hasDbXref "FMA:15972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015834 ; owl:annotatedTarget "lamina propria of duodenum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015837 ; owl:annotatedTarget "A dental pulp that is part of a incisor tooth." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0015837 ; owl:annotatedTarget "FMA has classes for very specific sublcasses but no generic grouping at this level" . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0015838 ; owl:annotatedTarget "FMA has classes for very specific sublcasses but no generic grouping at this level" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002260 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015842 ; owl:annotatedTarget "A tooth enamel organ that is part of a incisor tooth." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002260 ; owl:annotatedTarget "An epithelial cell of the parathyroid gland." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015844 ; owl:annotatedTarget "molar odontogenic papilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015844 ; owl:annotatedTarget "molar tooth odontogenic papilla" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002261 ; owl:annotatedTarget "An endothelial cell found in the mucosa associated with the facial skeleton." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015846 ; owl:annotatedTarget "An odontogenic mesenchyme that is part of a incisor tooth." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015847 ; owl:annotatedTarget "A upper jaw incisor that is in_the_left_side_of a dentition." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015848 ; owl:annotatedTarget "An incisor tooth that protrudes beyond the mouth." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015849 ; owl:annotatedTarget "An cuspid tooth that protrudes beyond the mouth." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Isobutyric acid" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002262 ; owl:annotatedTarget "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015852 ; owl:annotatedTarget "A upper jaw incisor that protrudes prominently from the mouth as a single median tusk, found in narwhals." . [] oboInOwl:source "DOI:10.1002/ar.22886" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015853 ; owl:annotatedTarget _:genid158348 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015853 ; owl:annotatedTarget "A dental pulp that is part of a narwhal tusk." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015854 ; owl:annotatedTarget "An anatomical line that connects two successive vertebral pedicles. The length of this line is known as the interpedicular distance." . [] oboInOwl:hasDbXref "HP:0008450" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0015854 ; owl:annotatedTarget "interpedicular distance" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0015860 ; owl:annotatedTarget obo:UBERON_0002507 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015870 ; owl:annotatedTarget "A lymph node that is part of a head." . [] oboInOwl:hasDbXref "Wikipedia:Facial_lymph_nodes", "http://www.bartleby.com/107/177.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015871 ; owl:annotatedTarget "Any of the lymph nodes that are part of a face." . [] oboInOwl:hasDbXref "FMA:61222" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015871 ; owl:annotatedTarget "buccal lymph node" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015873 ; owl:annotatedTarget "A zone of skin that is part of a heel." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0015873 ; owl:annotatedTarget "EMAPA:37354" . [] oboInOwl:hasDbXref "Wikipedia:Heel", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015875 ; owl:annotatedTarget "The part of the foot that is the projection of the calcaneus." . [] oboInOwl:hasDbXref "FMA:24994" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015875 ; owl:annotatedTarget "calcaneal region" . [] oboInOwl:hasDbXref "FMA:24994" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015875 ; owl:annotatedTarget "heel region" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0015875 ; owl:annotatedTarget "regio calcanea" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015917 ; owl:annotatedTarget "A lymph node that is located close to the surface." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002264 ; owl:annotatedTarget "A type of enteroendocrine cell found in the stomach that secretes glucagon." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0015918 ; owl:annotatedTarget "A lymph node that is located deeper within the organism, further from the surface." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016398 ; owl:annotatedTarget "A lymph node that is part of a hindlimb." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016399 ; owl:annotatedTarget "A lymph node that is part of a forelimb." . [] oboInOwl:hasDbXref "Wikipedia:Infrapatellar_fat_pad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016400 ; owl:annotatedTarget "The infrapatellar fat pad, also known as Hoffa's fat pad, is a cylindrical piece of fat that is situated under and behind the patella bone within the knee." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "A vertebral arch joint that is part of a cervical region of vertebral column." . [] oboInOwl:hasDbXref "FMA:13668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "cervical facet joint" . [] oboInOwl:hasDbXref "FMA:13668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "joint of cervical vertebral arch" . [] oboInOwl:hasDbXref "FMA:13668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "joint of cervical vertebral articular process" . [] oboInOwl:hasDbXref "FMA:13668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "zygapophyseal joint of cervical vertebrae" . [] oboInOwl:hasDbXref "FMA:13668" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016404 ; owl:annotatedTarget "zygapophysial joint of cervical vertebrae" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2,2-dimethylacetic acid" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016405 ; owl:annotatedTarget "A capillary that is part of a lung." . [] oboInOwl:hasDbXref "FMA:14121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016405 ; owl:annotatedTarget "capillary of lung" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016408 ; owl:annotatedTarget _:genid158428 . [] oboInOwl:hasDbXref "Wikipedia:Corona_of_glans_penis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016408 ; owl:annotatedTarget "The circumference of the base of the glans forms a rounded projecting border, the corona of the glans penis, overhanging a deep retroglandular sulcus, behind which is the neck of the penis." . [] oboInOwl:hasDbXref "FMA:19627" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016408 ; owl:annotatedTarget "glans corona" . [] oboInOwl:hasDbXref "Wikipedia:Corona_of_glans_penis" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016408 ; owl:annotatedTarget "corona glandis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016409 ; owl:annotatedTarget _:genid158433 . [] oboInOwl:hasDbXref "FMA:19649" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016409 ; owl:annotatedTarget "glans penile base" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016410 ; owl:annotatedTarget "A breast that is part of a male organism." . [] oboInOwl:hasDbXref "FMA:19901" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016410 ; owl:annotatedTarget "mamma masculina" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016412 ; owl:annotatedTarget _:genid158442 . [] oboInOwl:hasDbXref "FMA:24003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016412 ; owl:annotatedTarget "central part of body of vertebra" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002265 ; owl:annotatedTarget "A D cell located in the colon." . [] oboInOwl:hasDbXref "FMA:24023" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016413 ; owl:annotatedTarget "central medullary cavity of long bone" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016416 ; owl:annotatedTarget _:genid158450 . [] oboInOwl:hasDbXref "FMA:24816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016416 ; owl:annotatedTarget "Subdivision of thorax which is anterior to the plane of the posterior boundary of the middle mediastinum." . [] oboInOwl:hasDbXref "FMA:24816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016416 ; owl:annotatedTarget "anterior thoracic region" . [] oboInOwl:hasDbXref "FMA:24816" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016416 ; owl:annotatedTarget "front of chest" . [] oboInOwl:hasDbXref "HP:0007542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016416 ; owl:annotatedTarget "ventral chest" . [] oboInOwl:hasDbXref "Wikipedia:Nasion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016418 ; owl:annotatedTarget "The intersection of the frontal and two nasal bones of the human skull. Its manifestation on the visible surface of the face is a distinctly depressed area directly between the eyes, just superior to the bridge of the nose." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016419 ; owl:annotatedTarget _:genid158464 . [] oboInOwl:hasDbXref "FMA:29741" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016419 ; owl:annotatedTarget "bony part of arch of vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016422 ; owl:annotatedTarget "A compact bone tissue that is part of a bone tissue of long bone." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016423 ; owl:annotatedTarget "A compact bone tissue that is part of a diaphysis." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016425 ; owl:annotatedTarget "An epiphyseal plate that is part of a radius bone." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget _:genid158489 . [] oboInOwl:hasDbXref "Wikipedia:Palmar_branch_of_the_median_nerve", "http://medical-dictionary.thefreedictionary.com/palmar+branch+of+median+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "The palmar branch of the median nerve is a branch of the median nerve which arises at the lower part of the forearm and innervates skin of proximal central palm and thenar eminence." . [] oboInOwl:hasDbXref "FMA:44836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "median nerve palmar branch" . [] oboInOwl:hasDbXref "FMA:44836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "palmar branch of anterior interosseous nerve" . [] oboInOwl:hasDbXref "FMA:44836" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "palmar cutaneous branch of median nerve" . [] oboInOwl:hasDbXref "FMA:44836" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "ramus palmaris (nervus medianus)" . [] oboInOwl:hasDbXref "FMA:44836", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016430 ; owl:annotatedTarget "ramus palmaris nervus interossei antebrachii anterior" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002266 ; owl:annotatedTarget "A type D cell of the small intestine." . [] oboInOwl:hasDbXref "FMA:50060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016435 ; owl:annotatedTarget "Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016435 ; owl:annotatedTarget "EMAPA:37233" . [] oboInOwl:hasDbXref "Wikipedia:Glabella", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016440 ; owl:annotatedTarget "A zone of the frontal bone that connects the supraorbital rirdges." . [] oboInOwl:hasDbXref "FMA:52851" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016440 ; owl:annotatedTarget "glabella" . [] oboInOwl:hasDbXref "FMA:57136" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016440 ; owl:annotatedTarget "glabellar surface of frontal bone" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/median+palatine+suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016442 ; owl:annotatedTarget "The line of junction between the horizontal parts of the palatine bones that extends from both sides of the skull to form the posterior part of the hard palate." . [] oboInOwl:hasDbXref "FMA:52966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016442 ; owl:annotatedTarget "median palatine suture of skull" . [] oboInOwl:hasDbXref "FMA:52966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016442 ; owl:annotatedTarget "middle palatine suture of skull" . [] oboInOwl:hasDbXref "FMA:52966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016442 ; owl:annotatedTarget "midpalatal suture of skull" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016446 ; owl:annotatedTarget "A strand of hair that is part of a head." . [] oboInOwl:hasDbXref "FMA:54241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016446 ; owl:annotatedTarget "head hair" . [] oboInOwl:hasDbXref "FMA:54241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0016446 ; owl:annotatedTarget "hair of scalp" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2-METHYL-PROPIONIC ACID" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016447 ; owl:annotatedTarget "A strand of hair that is part of a trunk." . [] oboInOwl:hasDbXref "FMA:54250" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016447 ; owl:annotatedTarget "trunk hair" . [] oboInOwl:hasDbXref "FMA:55716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016452 ; owl:annotatedTarget "maxillary secondary premolar tooth" . [] oboInOwl:hasDbXref "FMA:55716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016452 ; owl:annotatedTarget "upper permanent premolar tooth" . [] oboInOwl:hasDbXref "FMA:55716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016452 ; owl:annotatedTarget "permanent upper premolar tooth" . [] oboInOwl:hasDbXref "FMA:55716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016452 ; owl:annotatedTarget "secondary upper premolar tooth" . [] oboInOwl:hasDbXref "FMA:55717" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016453 ; owl:annotatedTarget "lower permanent premolar tooth" . [] oboInOwl:hasDbXref "FMA:55717" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016453 ; owl:annotatedTarget "mandibular secondary premolar tooth" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002267 ; owl:annotatedTarget "A type D cell found in the stomach." . [] oboInOwl:hasDbXref "FMA:55717" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016453 ; owl:annotatedTarget "permanent lower premolar tooth" . [] oboInOwl:hasDbXref "FMA:55722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016454 ; owl:annotatedTarget "maxillary central secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016454 ; owl:annotatedTarget "upper central permanent incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016454 ; owl:annotatedTarget "I1" . [] oboInOwl:hasDbXref "FMA:55722" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016454 ; owl:annotatedTarget "permanent upper central incisor tooth" . [] oboInOwl:hasDbXref "FMA:55724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016455 ; owl:annotatedTarget "maxillary lateral secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016455 ; owl:annotatedTarget "upper lateral permanent incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016455 ; owl:annotatedTarget "I2" . [] oboInOwl:hasDbXref "HP:0002036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016458 ; owl:annotatedTarget "A hole in the diaphragm through which the esophagus passes." . [] oboInOwl:hasDbXref "FMA:58289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016458 ; owl:annotatedTarget "esophageal hiatus of diaphragm" . [] oboInOwl:hasDbXref "FMA:58289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016458 ; owl:annotatedTarget "oesophageal aperture" . [] oboInOwl:hasDbXref "FMA:58289" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016458 ; owl:annotatedTarget "oesophageal hiatus" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=70707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016459 ; owl:annotatedTarget "The central point on the posterior surface of the lens." . [] oboInOwl:hasDbXref "FMA:58898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016459 ; owl:annotatedTarget "polus posterior (lens)" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016459 ; owl:annotatedTarget "polus posterior lentis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016462 ; owl:annotatedTarget "A zone of skin in the periorbital region of the face." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016462 ; owl:annotatedTarget "EMAPA:37937" . [] oboInOwl:hasDbXref "FMA:59350" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016462 ; owl:annotatedTarget "skin of orbital part of face" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016464 ; owl:annotatedTarget _:genid158592 . [] oboInOwl:hasDbXref "HP:0011119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016464 ; owl:annotatedTarget "The midline prominence of the nose, extending from the nasal root to the tip." . [] oboInOwl:hasDbXref "FMA:59517" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016464 ; owl:annotatedTarget "nasal dorsum" . [] oboInOwl:hasDbXref "HP:0011119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016464 ; owl:annotatedTarget "nasal ridge" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget _:genid158597 . [] oboInOwl:source "http://php.med.unsw.edu.au" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget _:genid158599 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002274 ; owl:annotatedTarget "A cell type that secretes histamine." . [] oboInOwl:hasDbXref "Wikipedia:Antihelix" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget "On the pinna, a curved prominence of cartilage, parallel with and in front of the helix, is called the antihelix, also known as the anthelix; this divides above into two crura, the crura antihelicis, between which is a triangular depression, the fossa triangularis." . [] oboInOwl:hasDbXref "FMA:60995" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget "antihelical part of pinna" . [] oboInOwl:hasDbXref "FMA:60995" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget "antihelix (auricula)" . [] oboInOwl:hasDbXref "FMA:60995" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget "antihelix of pinna" . [] oboInOwl:hasDbXref "Wikipedia:Antihelix" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016466 ; owl:annotatedTarget "anthelix" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016467 ; owl:annotatedTarget _:genid158606 . [] oboInOwl:source "http://php.med.unsw.edu.au" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016467 ; owl:annotatedTarget _:genid158608 . [] oboInOwl:hasDbXref "Wikipedia:Antitragus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016467 ; owl:annotatedTarget "The antitragus is a feature of human ear anatomy. It is a small tubercle that points anteriorly. It is separated from the tragus by the intertragic notch." . [] oboInOwl:hasDbXref "FMA:61001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016467 ; owl:annotatedTarget "antitragal part of pinna" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016475 ; owl:annotatedTarget "A zone of skin that is part of a forehead." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016475 ; owl:annotatedTarget "EMAPA:37952" . [] oboInOwl:hasDbXref "FMA:63883" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016475 ; owl:annotatedTarget "forehead skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016476 ; owl:annotatedTarget "An incisor tooth that is part of a primary dentition." . [] oboInOwl:hasDbXref "FMA:84200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016476 ; owl:annotatedTarget "deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84200" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016476 ; owl:annotatedTarget "temporary incisor tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016478 ; owl:annotatedTarget "A stroma that is part of a liver." . [] oboInOwl:hasDbXref "FMA:17553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016478 ; owl:annotatedTarget "hepatic stroma" . [] oboInOwl:hasDbXref "FMA:17553" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016478 ; owl:annotatedTarget "stroma of liver" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2-Methylpropanoate" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_capsule_of_Glisson" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "A collagenous capsule covering the external surface of the liver." . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_capsule_of_Glisson" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "capsula fibrosa perivascularis" . [] oboInOwl:hasDbXref "FMA:15813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "fibrous capsule of liver" . [] oboInOwl:hasDbXref "FMA:15813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "glisson's capsule" . [] oboInOwl:hasDbXref "FMA:15813" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "hepatic capsule" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "tunica fibrosa (hepar)" . [] oboInOwl:hasDbXref "FMA:15813", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "tunica fibrosa hepatis" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_capsule_of_Glisson" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "fibrous capsule of Glisson" . [] oboInOwl:hasDbXref "Wikipedia:Fibrous_capsule_of_Glisson" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016479 ; owl:annotatedTarget "liver capsule" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016480 ; owl:annotatedTarget obo:UBERON_0016478 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016481 ; owl:annotatedTarget "A lymph node that is part of a bronchus." . [] oboInOwl:hasDbXref "NLXANAT:090817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016490 ; owl:annotatedTarget "Is the sensory system for the sense of hearing." . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0016490 ; owl:annotatedTarget "Auditory system is general anatomical term in FMA" . [] oboInOwl:source "ncithesaurus:Auditory_System" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016490 ; owl:annotatedTarget "UMLS:C0587901" . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget obo:UBERON_0004765 . [] oboInOwl:source "VSAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget _:genid158663 . [] oboInOwl:hasDbXref "VSAO:0000183", "VSAO:curator", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/207", "https://github.com/obophenotype/uberon/issues/80" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget "Skeletal element that functionally replaces the notochord[VSAP,modified]." . [] oboInOwl:date_retrieved "2012-08-14" ; oboInOwl:external_class "VSAO:0000183" ; oboInOwl:ontology "VSAO" ; oboInOwl:source "VSAO:curator" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget "Skeletal element that surrounds the notochord.[VSAO]" . [] oboInOwl:source "MP:0000141,ISBN:0-683-40008-8,PMID:10572046" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget "the main cylindrical portion of the vertebra ventral to the vertebral canal" . [] oboInOwl:hasDbXref "VSAO:0000183" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016491 ; owl:annotatedTarget "centrum" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016509 ; owl:annotatedTarget "Luminal space of the right ventricle of the heart." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002275 ; owl:annotatedTarget "A PP cell located in the islets of the pancreas." . [] oboInOwl:hasDbXref "EMAPA:26047" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016509 ; owl:annotatedTarget "right ventricle lumen" . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016509 ; owl:annotatedTarget "right ventricular cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016510 ; owl:annotatedTarget "An epithelium that is part of a male urethra." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016510 ; owl:annotatedTarget "male urethral epithelium" . [] oboInOwl:hasDbXref "EMAPA:30467" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016510 ; owl:annotatedTarget "urethral epithelium of male" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016512 ; owl:annotatedTarget "An anatomical space that is part of a duodenum." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016512 ; owl:annotatedTarget "doudenal lumen" . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016512 ; owl:annotatedTarget "duodenal lumen" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016513 ; owl:annotatedTarget "Luminal space of the left atrium of the heart." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016513 ; owl:annotatedTarget "left atrial cavity" . [] oboInOwl:hasDbXref "EMAPA:26011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016513 ; owl:annotatedTarget "left atrium lumen" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016514 ; owl:annotatedTarget "Luminal space of the left ventricle of the heart." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016514 ; owl:annotatedTarget "left ventricular cavity" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016517 ; owl:annotatedTarget "An anatomical space that is part of a jejunum." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016517 ; owl:annotatedTarget "jejunal lumen" . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016517 ; owl:annotatedTarget "jejunum lumen" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016520 ; owl:annotatedTarget "An epithelium that is part of a female urethra." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016520 ; owl:annotatedTarget "female urethral epithelium" . [] oboInOwl:hasDbXref "EMAPA:30470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016520 ; owl:annotatedTarget "urethral epithelium of female" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016522 ; owl:annotatedTarget "Luminal space of the right atrium of the heart." . [] oboInOwl:hasDbXref "FMA:FMA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016522 ; owl:annotatedTarget "right atrial cavity" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002293 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget obo:UBERON_0016526 . [] oboInOwl:hasDbXref "FMA:61824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border." . [] oboInOwl:source "MM" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000116 ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though" . [] oboInOwl:hasDbXref "FMA:61824" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "frontal region" . [] oboInOwl:hasDbXref "FMA:61824", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "regio frontalis" . [] oboInOwl:source "BIRNLEX:928", "ncithesaurus:Frontal_Lobe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "UMLS:C0016733" . [] oboInOwl:source "BIRNLEX:928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "UMLS:C1268977" . [] oboInOwl:source "BIRNLEX:928" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "neuronames:56" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2-Methylpropanoic acid" . [] oboInOwl:hasDbXref "FMA:72208", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002293 ; owl:annotatedTarget "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." . [] oboInOwl:hasDbXref "NeuroNames:56" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "lobi frontales" . [] oboInOwl:hasDbXref "Wikipedia:Frontal_lobe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "lobus frontalis" . [] oboInOwl:hasDbXref "FMA:61824" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0016525 ; owl:annotatedTarget "frontal cortex" . [] oboInOwl:hasDbXref "FMA:61823" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified]." . [] oboInOwl:hasDbXref "FMA:61823" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "cerebral hemisphere lobe" . [] oboInOwl:hasDbXref "BTO:0000445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "cerebral lobe" . [] oboInOwl:hasDbXref "BIRNLEX:922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "lobe of cerebral cortex" . [] oboInOwl:hasDbXref "BIRNLEX:922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "lobe parts of cerebral cortex" . [] oboInOwl:hasDbXref "FMA:77800", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "lobi cerebri" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:9264335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002294 ; owl:annotatedTarget "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." . [] oboInOwl:hasDbXref "FMA:68603" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "cerebral cortical segment" . [] oboInOwl:hasDbXref "BIRNLEX:922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "lobes of the brain" . [] oboInOwl:hasDbXref "FMA:68603" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "regional organ part of cerebral cortex" . [] oboInOwl:hasDbXref "BIRNLEX:922" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016526 ; owl:annotatedTarget "segment of cerebral cortex" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016528 ; owl:annotatedTarget "A white matter of cerebral lobe that is part of a frontal lobe." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016529 ; owl:annotatedTarget "Grey matter neocortex region of a lobe of the cerebral hemisphere." . [] oboInOwl:hasDbXref "FMA:242197" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016529 ; owl:annotatedTarget "cortex of cerebral hemisphere lobe" . [] oboInOwl:hasDbXref "FMA:242197" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016529 ; owl:annotatedTarget "cortex of lobe of cerebral hemisphere" . [] oboInOwl:hasDbXref "FMA:242197" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016529 ; owl:annotatedTarget "gray matter of lobe of cerebral hemisphere" . [] oboInOwl:hasDbXref "NLX:79282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016530 ; owl:annotatedTarget "Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border." . [] oboInOwl:hasDbXref "FMA:242203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016530 ; owl:annotatedTarget "cortex of parietal lobe" . [] oboInOwl:hasDbXref "FMA:242203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016530 ; owl:annotatedTarget "parietal lobe cortex" . [] oboInOwl:hasDbXref "DHBA:10208" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016530 ; owl:annotatedTarget "parietal neocortex" . [] oboInOwl:hasDbXref "FMA:242203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016530 ; owl:annotatedTarget "gray matter of parietal lobe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016531 ; owl:annotatedTarget "A white matter of cerebral lobe that is part of a parietal lobe." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016534 ; owl:annotatedTarget "A white matter of cerebral lobe that is part of a temporal lobe." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016536 ; owl:annotatedTarget "A white matter of cerebral lobe that is part of a limbic lobe." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002308 ; owl:annotatedTarget "An epithelial cell of a skin gland." . [] oboInOwl:hasDbXref "NLX:94939" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016538 ; owl:annotatedTarget "Gray matter of the temporal region of the neocortex, located in the temporal lobe in gyrencephalic animals." . [] oboInOwl:hasDbXref "FMA:242201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016538 ; owl:annotatedTarget "cortex of temporal lobe" . [] oboInOwl:hasDbXref "FMA:242201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016538 ; owl:annotatedTarget "temporal lobe cortex" . [] oboInOwl:hasDbXref "DHBA:10235" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016538 ; owl:annotatedTarget "temporal neocortex" . [] oboInOwl:hasDbXref "FMA:242201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016538 ; owl:annotatedTarget "gray matter of temporal lobe" . [] oboInOwl:hasDbXref "SANBI:mhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002312 ; owl:annotatedTarget "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." . [] oboInOwl:hasDbXref "FMA:242234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016542 ; owl:annotatedTarget "cortex of limbic lobe" . _:genid156572 oboInOwl:hasDbXref "FMA:242234" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016542 ; owl:annotatedTarget "limbic lobe cortex" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001616 . [] oboInOwl:hasDbXref "FMA:242234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016542 ; owl:annotatedTarget "gray matter of limbic lobe" . ( ) . [] oboInOwl:hasDbXref "PMID:23020903", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016545 ; owl:annotatedTarget "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016548 ; owl:annotatedTarget "A layer of of the central nervous system that is part of gray matter." . [] oboInOwl:hasDbXref "FMA:83142" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016548 ; owl:annotatedTarget "gray matter layer of neuraxis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016549 ; owl:annotatedTarget "A layer of of the central nervous system that is composed of white matter." . [] oboInOwl:hasDbXref "FMA:83898" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016549 ; owl:annotatedTarget "white matter layer of neuraxis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016552 ; owl:annotatedTarget "Mucus produced in the respiratory tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "2-Methylpropionsaeure" . _:genid156602 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0003001 ; owl:someValuesFrom obo:UBERON_0000076, obo:UBERON_0004785 . [] oboInOwl:hasDbXref "Wikipedia:Nasal_mucus#Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016553 ; owl:annotatedTarget "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016554 ; owl:annotatedTarget "A white matter that is part of the midbrain." . [] oboInOwl:hasDbXref "HBA:MESWM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016554 ; owl:annotatedTarget "mesencephalic white matter" . _:genid156616 oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016565 ; owl:annotatedTarget "A blood vessel that is part of a cerebellum." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0002323 . [] oboInOwl:hasDbXref "AEO:0000204", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016566 ; owl:annotatedTarget "An roughly circular indentation in a surface." . [] oboInOwl:hasDbXref "FMA:68861" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016570 ; owl:annotatedTarget "rexed lamina" . _:genid156625 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006208, obo:UBERON_0013156 . [] oboInOwl:hasDbXref "http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016611 ; owl:annotatedTarget "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." . _:genid156630 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000477 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006208 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0003066 ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000084 . [] oboInOwl:hasDbXref "http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016612 ; owl:annotatedTarget "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002313 ; owl:annotatedTarget "An ecto-epithelial cell of the prostate gland that secretes hormones." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016854 ; owl:annotatedTarget "The dorsal region of the optic cup that gives rise to the dorsal part of the retina." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016854 ; owl:annotatedTarget "dorsal optic cup" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016854 ; owl:annotatedTarget "dorsal region of optic cup" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016855 ; owl:annotatedTarget "The ventral region of the optic cup that gives rise to the ventral part of the retina." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016855 ; owl:annotatedTarget "ventral optic cup" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016855 ; owl:annotatedTarget "ventral region of optic cup" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016879 ; owl:annotatedTarget "Primordium that develops into the central nervous system." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016880 ; owl:annotatedTarget "Primordium that develops into the nervous system." . [] oboInOwl:hasDbXref "AAO:0000477" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016880 ; owl:annotatedTarget "presumptive nervous system" . [] oboInOwl:evidence "definitional" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016884 ; owl:annotatedTarget _:genid158906 . [] oboInOwl:hasDbXref "http://www.innerbody.com/image/skel17.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016884 ; owl:annotatedTarget "The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016885 ; owl:annotatedTarget "Epithelium lining the distalmost portion of the digestive tract." . [] oboInOwl:hasDbXref "BTO:0005445" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0016885 ; owl:annotatedTarget "rectum epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016886 ; owl:annotatedTarget "Any muscle tissue of the distalmost portion of the digestive tract." . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016887 ; owl:annotatedTarget obo:UBERON_0000481 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016887 ; owl:annotatedTarget _:genid158921 . [] oboInOwl:hasDbXref "AEO:0000195", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016887 ; owl:annotatedTarget "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002319 ; owl:annotatedTarget "A cell that is part of the nervous system." . [] oboInOwl:hasDbXref "AEO:0000195" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016887 ; owl:annotatedTarget "extraembryonic component" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016888 ; owl:annotatedTarget obo:UBERON_0005423 . [] oboInOwl:hasDbXref "AEO:0000132", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016888 ; owl:annotatedTarget "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016896 ; owl:annotatedTarget "A periosteum that is part of a long bone." . [] oboInOwl:hasDbXref "FMA:32677" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016896 ; owl:annotatedTarget "long bone periosteum" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Dimethylacetic acid" . [] oboInOwl:hasDbXref "FMA:59820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016910 ; owl:annotatedTarget "lip frenulum" . [] oboInOwl:hasDbXref "FMA:59820" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016910 ; owl:annotatedTarget "medial labial frenulum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016912 ; owl:annotatedTarget _:genid158947 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016912 ; owl:annotatedTarget "A frenulum of lip that is part of a upper lip." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016912 ; owl:annotatedTarget "f. labii superioris" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016912 ; owl:annotatedTarget "frenulum labii superioris" . [] oboInOwl:hasDbXref "FMA:59821" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016912 ; owl:annotatedTarget "upper lip frenulum" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0016913 ; owl:annotatedTarget _:genid158958 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016913 ; owl:annotatedTarget "A frenulum of lip that is part of a lower lip." . [] oboInOwl:hasDbXref "FMA:59822" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016913 ; owl:annotatedTarget "lower lip frenulum" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_lower_lip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016913 ; owl:annotatedTarget "f. labii inferioris" . [] oboInOwl:hasDbXref "Wikipedia:Frenulum_of_lower_lip" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016913 ; owl:annotatedTarget "frenulum labii inferioris" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016915 ; owl:annotatedTarget "The zone of the skin that surrounds a lip and is colored red due to thin epithelium and presence of eleidin." . [] oboInOwl:hasSynonymType core:DUBIOUS ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0016915 ; owl:annotatedTarget "vermillion" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002320 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016918 ; owl:annotatedTarget "A vermilion that is part of a upper lip." . [] oboInOwl:hasDbXref "FMA:59827" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016918 ; owl:annotatedTarget "vermilion of upper lip" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016919 ; owl:annotatedTarget "A vermilion that is part of a lower lip." . [] oboInOwl:hasDbXref "FMA:59828" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016919 ; owl:annotatedTarget "vermilion of lower lip" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002320 ; owl:annotatedTarget "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." . [] oboInOwl:hasDbXref "UBERON:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0016928 ; owl:annotatedTarget "A metaphysis that is part of a fibula." . [] oboInOwl:hasDbXref "FMA:33745" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0016928 ; owl:annotatedTarget "fibula metaphysis" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016943 ; owl:annotatedTarget "LP" . [] oboInOwl:hasDbXref "FMA:0618947256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002321 ; owl:annotatedTarget "A cell of the embryo." . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0016944 ; owl:annotatedTarget "UP" . [] oboInOwl:hasDbXref "PHENOSCAPE:Nizar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017163 ; owl:annotatedTarget "A bony structure embedded in skin, roughly equivalent to osteoderms." . [] oboInOwl:hasDbXref "UBERONTEMP:3b77fb04-1e62-43af-a84b-5d5eb7388525" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0017163 ; owl:annotatedTarget "bony tubercles" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017261 ; owl:annotatedTarget "A sesamoid element that is part of a tarsal skeleton." . (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) . _:genid156785 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0007120 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001709 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007116 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0007270 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Isobutanoate" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017615 ; owl:annotatedTarget "A set of teeth in which each tooth that attaches to a vomer." . _:genid156802 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0005486 _:genid156804 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001377 . _:genid156804 a owl:Restriction ; owl:onProperty obo:BSPO_0000126, obo:RO_0002372 ; owl:someValuesFrom obo:UBERON_0000033, obo:UBERON_0000981 . [] oboInOwl:hasDbXref "FMA:52568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017635 ; owl:annotatedTarget "paired dural venous sinus" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002323 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017648 ; owl:annotatedTarget "The ventral part of the body wall." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0017648 ; owl:annotatedTarget "EMAPA:37984" . [] oboInOwl:hasDbXref "FMA:86934" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0017648 ; owl:annotatedTarget "anterior body wall" . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017649 ; owl:annotatedTarget "The dorsal part of the body wall." . [] oboInOwl:hasDbXref "BFO:0000066", "GOC:tfm", "PMID:3211847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002323 ; owl:annotatedTarget "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." . [] oboInOwl:hasDbXref "AEO:0001016", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017650 ; owl:annotatedTarget "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017651 ; owl:annotatedTarget "A primordium that has the potential to develop into a saliva-secreting gland." . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/buccal%20gland" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017654 ; owl:annotatedTarget "Any of the small racemose mucous glands in the mucous membrane lining the cheeks." . [] oboInOwl:hasDbXref "FMA:19624" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017659 ; owl:annotatedTarget "urethral surface of penis" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017670 ; owl:annotatedTarget "A bony part of vertebral arch that is part of a cervical vertebral arch." . [] oboInOwl:hasDbXref "FMA:29794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017670 ; owl:annotatedTarget "bony part of arch of cervical vertebra" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017671 ; owl:annotatedTarget "A bony part of vertebral arch that is part of a sacral vertebra 1." . [] oboInOwl:hasDbXref "FMA:32395" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017671 ; owl:annotatedTarget "bony part of vertebral arch of first sacral segment" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017672 ; owl:annotatedTarget "A viscus that is part of a abdomen." . [] oboInOwl:hasDbXref "FMA:32413" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017672 ; owl:annotatedTarget "abdominal viscera" . [] oboInOwl:hasDbXref "FMA:32413" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017672 ; owl:annotatedTarget "abdominal viscera set" . [] oboInOwl:hasDbXref "FMA:32413" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017672 ; owl:annotatedTarget "set of abdominal viscera" . [] oboInOwl:hasDbXref "FMA:52856" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017690 ; owl:annotatedTarget "facies interna (os frontale)" . [] oboInOwl:hasDbXref "FMA:52856", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017690 ; owl:annotatedTarget "facies interna ossis frontalis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017692 ; owl:annotatedTarget "Internal (endosteal) surface of the base of skull." . [] oboInOwl:hasDbXref "FMA:53128", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017692 ; owl:annotatedTarget "basis cranii interna" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0017716 ; owl:annotatedTarget _:genid159105 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/Thenar+muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017716 ; owl:annotatedTarget "A raised fleshy area on the palm of the hand near the base of the thumb." . [] oboInOwl:hasDbXref "FMA:61520" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017716 ; owl:annotatedTarget "thenar part of palm" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget obo:CL_0002159 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0017717 ; owl:annotatedTarget _:genid159109 . [] oboInOwl:hasDbXref "Wikipedia:Hypothenar_eminence" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017717 ; owl:annotatedTarget "Hypothenar refers to a group of three muscles of the palm that control the motion of the little finger. The three muscles are: Abductor digiti minimi Flexor digiti minimi Opponens digiti minimi." . [] oboInOwl:hasDbXref "FMA:61523" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017717 ; owl:annotatedTarget "hypothenar part of palm" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002325 ; owl:annotatedTarget "The milk-producing cell of the alveolar unit that emerges during pregnancy." . [] oboInOwl:hasDbXref "HPO:probinson" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017732 ; owl:annotatedTarget "A ridge of tissue that extends along the midline of the scrotum." . [] oboInOwl:hasDbXref "FMA:75130" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017732 ; owl:annotatedTarget "scrotal raphe" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017748 ; owl:annotatedTarget "A primary incisor tooth that is part of a lower jaw region." . [] oboInOwl:hasDbXref "FMA:84215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0017748 ; owl:annotatedTarget "lower deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84215" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0017748 ; owl:annotatedTarget "deciduous lower incisor tooth" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017750 ; owl:annotatedTarget "A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Isobuttersaeure" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0017751 ; owl:annotatedTarget "A proximal mesopodial endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018099 ; owl:annotatedTarget "An endochondral element in the distal portion of the mesopodial skeleton, between the central mesopodial skeleton and the metapodial skeleton." . [] oboInOwl:hasDbXref "UBERON:cjm" ; oboInOwl:hasSynonymType core:SYSTEMATIC ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018099 ; owl:annotatedTarget "distal mesopodial" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018100 ; owl:annotatedTarget "A distal mesopodial endochondral element that is composed primarily of cartilage tissue." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018101 ; owl:annotatedTarget "A distal mesopodial endochondral element that is composed primarily of a pre-cartilage condensation." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018102 ; owl:annotatedTarget "A distal mesopodial endochondral element that is composed primarily of a bone tissue." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "A muscle layer that is part of the rectum." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19022771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002327 ; owl:annotatedTarget "An epithelial cell of the mammary gland." . [] oboInOwl:hasDbXref "FMA:15035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "muscular coat of rectum" . [] oboInOwl:hasDbXref "FMA:15035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "muscularis externa of rectum" . [] oboInOwl:hasDbXref "FMA:15035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "rectal muscularis propria" . [] oboInOwl:hasDbXref "FMA:15035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "tunica muscularis (rectum)" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018111 ; owl:annotatedTarget "tunica muscularis recti" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018112 ; owl:annotatedTarget "Any portion of smooth muscle tissue that is part of the rectum." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018113 ; owl:annotatedTarget "A kidney interstitium that is part of a left kidney." . [] oboInOwl:hasDbXref "FMA:74271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018113 ; owl:annotatedTarget "left renal stroma" . [] oboInOwl:hasDbXref "FMA:74271" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018113 ; owl:annotatedTarget "stroma of left kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018114 ; owl:annotatedTarget "A kidney interstitium that is part of a right kidney." . [] oboInOwl:hasDbXref "FMA:74270" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018114 ; owl:annotatedTarget "right renal stroma" . [] oboInOwl:hasDbXref "FMA:74270" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018114 ; owl:annotatedTarget "stroma of right kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018115 ; owl:annotatedTarget "A renal pelvis that is part of a left ureter." . [] oboInOwl:hasDbXref "FMA:15579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018115 ; owl:annotatedTarget "pelvis of left ureter" . [] oboInOwl:hasDbXref "FMA:15579" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018115 ; owl:annotatedTarget "renal pelvis of left kidney" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018116 ; owl:annotatedTarget "A renal pelvis that is part of a right ureter." . [] oboInOwl:hasDbXref "FMA:15578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018116 ; owl:annotatedTarget "pelvis of right kidney" . [] oboInOwl:hasDbXref "FMA:15578" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018116 ; owl:annotatedTarget "pelvis of right ureter" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018117 ; owl:annotatedTarget "A renal cortex interstitium that is part of a left kidney." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018118 ; owl:annotatedTarget "A renal cortex interstitium that is part of a right kidney." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018119 ; owl:annotatedTarget "A renal medulla interstitium that is part of a left kidney." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018120 ; owl:annotatedTarget "A renal medulla interstitium that is part of a right kidney." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002328 ; owl:annotatedTarget "An epithelial cell of the bronchus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018132 ; owl:annotatedTarget "Encapsulated adipose tissue that is part of a tail." . [] oboInOwl:source "WP" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000008 ; owl:annotatedSource obo:UBERON_0018132 ; owl:annotatedTarget "The platypus uses its tail for storage of fat reserves (an adaptation also found in animals such as the Tasmanian devil and fat-tailed sheep)" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "Isobutyrate" . _:genid157000 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0005805, obo:UBERON_0006076 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018142 ; owl:annotatedTarget "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx)." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018143 ; owl:annotatedTarget "A transverse process that is part of a cervical vertebra." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018144 ; owl:annotatedTarget "A rib that is attached to a cervical vertebra." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0018144 ; owl:annotatedTarget "EMAPA:37825" . _:genid157023 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018145 ; owl:annotatedTarget "A rib that is attached to a lumbar vertebra." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000956 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018146 ; owl:annotatedTarget "A transverse process that is part of a lumbar vertebra." . [] oboInOwl:hasDbXref "FMA:65469", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018146 ; owl:annotatedTarget "costa lumbalis" . [] oboInOwl:hasDbXref "FMA:16080" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018146 ; owl:annotatedTarget "lumbar transverse process" . [] oboInOwl:source "MFMO-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018149 ; owl:annotatedTarget _:genid159271 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621", "https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Angle-of-mouth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018149 ; owl:annotatedTarget "The lateral limit of each lateral part of the oral fissure." . [] oboInOwl:hasDbXref "FMA:77269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018149 ; owl:annotatedTarget "angle of mouth" . [] oboInOwl:hasDbXref "FMA:77269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018149 ; owl:annotatedTarget "mouth angle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018150 ; owl:annotatedTarget "A zone of skin that is part of a lower lip." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18757316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002332 ; owl:annotatedTarget "A ciliated cell of the bronchus." . [] oboInOwl:hasDbXref "FMA:24767" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018150 ; owl:annotatedTarget "lower lip skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018151 ; owl:annotatedTarget "A zone of skin that is part of a upper lip." . [] oboInOwl:hasDbXref "FMA:24765" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018151 ; owl:annotatedTarget "upper lip skin" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018154 ; owl:annotatedTarget "A ligament that is part of a middle ear." . [] oboInOwl:hasDbXref "ISBN:9781604061550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018156 ; owl:annotatedTarget "A skeletal ligament that attaches to the malleus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018226 ; owl:annotatedTarget "An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels." . [] oboInOwl:hasDbXref "FMA:67999" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018226 ; owl:annotatedTarget "pulmonary lymphatic chain" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018227 ; owl:annotatedTarget "A lymphatic vessel that is part of a lung." . [] oboInOwl:hasDbXref "MESH:G06.535.805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018229 ; owl:annotatedTarget "A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex." . [] oboInOwl:hasDbXref "MESH:G06.535.805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018229 ; owl:annotatedTarget "renin angiotensin aldosterone system" . [] oboInOwl:hasDbXref "MESH:G06.535.805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018229 ; owl:annotatedTarget "renin angiotensin system" . [] oboInOwl:hasDbXref "MESH:G06.535.805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018229 ; owl:annotatedTarget "renin-angiotensin system" . [] oboInOwl:hasDbXref "MESH:G06.535.805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018229 ; owl:annotatedTarget "renin-angiotensin-aldosterone system" . [] oboInOwl:source "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018232 ; owl:annotatedTarget obo:UBERON_0000382 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018232 ; owl:annotatedTarget "A sweat gland that is part of a axilla." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018232 ; owl:annotatedTarget "axillary apocrine sweat gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018232 ; owl:annotatedTarget "sweat gland of axilla" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018234 ; owl:annotatedTarget "A stroma that is part of a pancreas." . [] oboInOwl:hasDbXref "FMA:63121" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018234 ; owl:annotatedTarget "pancreatic stroma" . [] oboInOwl:hasDbXref "ISBN:0123813611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018235 ; owl:annotatedTarget "A capsule that divides the parenchyma of the pancreas into lobes and lobules." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "alpha-isobutyric acid" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17507398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002333 ; owl:annotatedTarget "A fat cell derived from a neural crest cell." . [] oboInOwl:hasDbXref "GO:0021654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018239 ; owl:annotatedTarget "A boundary delimiting a rhombomere." . [] oboInOwl:hasDbXref "GOC:tfm", "MESH:D009061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002336 ; owl:annotatedTarget "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018243 ; owl:annotatedTarget _:genid159351 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018243 ; owl:annotatedTarget "A vein that supplies blood to the thymus." . [] oboInOwl:hasDbXref "FMA:10647" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018243 ; owl:annotatedTarget "thymic branch of internal thoracic artery" . [] oboInOwl:hasDbXref "Wikipedia:Thymic_branches_of_internal_thoracic_artery" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018243 ; owl:annotatedTarget "thymic arteries" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018246 ; owl:annotatedTarget "A vein that drains a thyroid gland." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018247 ; owl:annotatedTarget "An artery that supplies a cervical thymus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018251 ; owl:annotatedTarget "One of the veins draining a meninix." . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_veins" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018252 ; owl:annotatedTarget "Accompanying vein of internal pudendal artery." . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_veins" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018252 ; owl:annotatedTarget "vena pudenda interna" . [] oboInOwl:hasDbXref "Wikipedia:Internal_pudendal_veins" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018252 ; owl:annotatedTarget "internal pudic vein" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018254 ; owl:annotatedTarget _:genid159375 . [] oboInOwl:hasDbXref "Wikipedia:Jejunal_veins", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018255 ; owl:annotatedTarget "A branch of the superior mesenteric artery that supplies the jejunum." . [] oboInOwl:hasDbXref "FMA:14808" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018255 ; owl:annotatedTarget "jejunal branch of superior mesenteric artery" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018256 ; owl:annotatedTarget "A vein that drains a lacrimal gland." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018257 ; owl:annotatedTarget "Any portion of submucosa that lines the digestive tract." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018260 ; owl:annotatedTarget "Any organ component layer that consists of muscle tissue." . [] oboInOwl:external_ontology "NCIT" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0018260 ; owl:annotatedTarget "NCITA class may refer to smooth muscle only" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:15226377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002339 ; owl:annotatedTarget "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018261 ; owl:annotatedTarget "A muscular coat that is part of a digestive tract." . [] oboInOwl:source "MFMO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018265 ; owl:annotatedTarget _:genid159409 . [] oboInOwl:hasDbXref "MFMO:0000109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018265 ; owl:annotatedTarget "The anterior or rostral end of the zygomatic arch, which includes the temporal process of the zygomatic bone, but also including some of the body of the zygomatic bone. It may also include the zygomatico-temporal suture and the most rostral portion of the zygomatic process of the temporal bone." . [] oboInOwl:hasDbXref "GOC:tfm", "PMCID:PMC2673349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002341 ; owl:annotatedTarget "An undifferentiated cell of the prostate epithelium that lacks secretory activity." . [] oboInOwl:hasDbXref "PHENOSCAPE:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018299 ; owl:annotatedTarget "Tooth of the lower jaw that is adjacent to the mandibular symphysis." . [] oboInOwl:hasDbXref "PHENOSCAPE:Alex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018302 ; owl:annotatedTarget "First molar (counting anteroposteriorly) in the upper jaw." . [] oboInOwl:hasDbXref "PHENOSCAPE:Alex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018303 ; owl:annotatedTarget "Tissue that is part of some adrenal gland." . [] oboInOwl:hasDbXref "ncithesaurus:Adrenal_Gland_Tissue" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018303 ; owl:annotatedTarget "adrenal gland tissue" . [] oboInOwl:hasDbXref "PHENOSCAPE:alex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018321 ; owl:annotatedTarget "Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX)." . [] oboInOwl:hasDbXref "PHENOSCAPE:alex" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018326 ; owl:annotatedTarget "Situated just caudal to the acetabulum, the foramen is bound dorsally by the illium and ventrally by the ischium. The foramen transmitts the ischiadic nerves and vessels (Baumel et al. 1993)." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "alpha-methylpropanoic acid" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018376 ; owl:annotatedTarget "The molar tooth of the upper or lower jaw that is phylogenetically number 1." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018405 ; owl:annotatedTarget _:genid159445 . [] oboInOwl:hasDbXref "FMA:53243" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018405 ; owl:annotatedTarget "inferior dental nerve" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018406 ; owl:annotatedTarget _:genid159452 . [] oboInOwl:hasDbXref "Wikipedia:Mental_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018406 ; owl:annotatedTarget "Mental nerve is a general somatic afferent (sensory) nerve which provides sensation to the anterior aspects of the chin and lower lip as well as the buccal gingivae of the mandibular anterior teeth and the premolars. It is a branch of the posterior trunk of the inferior alveolar nerve, which is itself a branch of the mandibular division of the trigeminal nerve (CN V). The nerve emerges at the mental foramen in the mandibula, and divides beneath the Depressor anguli oris muscle into three branches: one descends to the skin of the chin. two ascend to the skin and mucous membrane of the lower lip. These branches communicate freely with the facial nerve." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget obo:CL_0000115 . [] oboInOwl:hasDbXref "Wikipedia:Infraorbital_nerve", "http://medical-dictionary.thefreedictionary.com/infra-orbital+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018408 ; owl:annotatedTarget "A branch of the maxillary nerve that enters the infraorbital canal and innervates the lower eyelid, upper lip, the nasal vestibule, the upper incisors, canines, premolars, upper gums, lower eyelid and conjunctiva, and part of the nose." . [] oboInOwl:hasDbXref "FMA:52978" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018408 ; owl:annotatedTarget "infraorbital nerve" . [] oboInOwl:hasDbXref "Wikipedia:Infraorbital_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018408 ; owl:annotatedTarget "infra-orbital nerve" . [] oboInOwl:hasDbXref "Wikipedia:Infraorbital_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018408 ; owl:annotatedTarget "infraorbital portion" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018411 ; owl:annotatedTarget "A skeletal ligament that is part of a hip joint." . [] oboInOwl:hasDbXref "GOC:tfm", "ISSN:0452-3458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." . [] oboInOwl:hasDbXref "FMA:42868" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018411 ; owl:annotatedTarget "hip joint ligament" . [] oboInOwl:hasDbXref "Wikipedia:Facial_canal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018413 ; owl:annotatedTarget "A Z-shaped canal running through the temporal bone from the internal acoustic meatus to the stylomastoid foramen. It is located within the middle ear region, according to its shape it is divided into three main segments: the labyrinthine, the tympanic, and the mastoidal segment ." . [] oboInOwl:hasDbXref "FMA:54952", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018413 ; owl:annotatedTarget "canalis nervi facialis" . [] oboInOwl:hasDbXref "FMA:54952" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018413 ; owl:annotatedTarget "facial canal" . [] oboInOwl:hasDbXref "FMA:54952" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018413 ; owl:annotatedTarget "fallopian canal" . [] oboInOwl:hasDbXref "FMA:75621" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002350 ; owl:annotatedTarget "endothelial cell of endocardium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018415 ; owl:annotatedTarget "An bone foramen in the ethmoid bone." . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018415 ; owl:annotatedTarget "foramina ethmoidalia" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018415 ; owl:annotatedTarget "ethmoid foramina" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018415 ; owl:annotatedTarget "ethmoidal foramina" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20025937", "PMID:20217494", "PMID:22728667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002351 ; owl:annotatedTarget "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/nasal+foramina" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018508 ; owl:annotatedTarget "A vascular foramen opening on the outer surface of a nasal bone." . [] oboInOwl:hasDbXref "Wikipedia:Nasal_foramina" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018508 ; owl:annotatedTarget "foramina nasalia" . [] oboInOwl:hasDbXref "FMA:57653" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018508 ; owl:annotatedTarget "nasal foramina" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018529 ; owl:annotatedTarget "An inguinal ring that is part of a female reproductive system." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018530 ; owl:annotatedTarget "An inguinal ring that is part of a male reproductive system." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018531 ; owl:annotatedTarget "A deep inguinal ring that is part of a female reproductive system." . [] oboInOwl:hasDbXref "MA:0003252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018531 ; owl:annotatedTarget "female external inguinal ring" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018532 ; owl:annotatedTarget "A deep inguinal ring that is part of a male reproductive system." . [] oboInOwl:hasDbXref "MA:0003251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018532 ; owl:annotatedTarget "female internal inguinal ring" . [] oboInOwl:hasDbXref "MFMO:0000147" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018542 ; owl:annotatedTarget "The region of the mandible on or near the midline (near the mandiblular symphysis)." . [] oboInOwl:hasDbXref "MFMO:0000147" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0018542 ; owl:annotatedTarget "symphyseal region" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018543 ; owl:annotatedTarget "The anatomical space within the intestine." . [] oboInOwl:hasDbXref "FMA:14586" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018543 ; owl:annotatedTarget "intestinal lumen" . [] oboInOwl:hasDbXref "ZFA:0005807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018543 ; owl:annotatedTarget "intestine lumen" . [] oboInOwl:hasDbXref "ZFA:0005807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018543 ; owl:annotatedTarget "gut lumen" . [] oboInOwl:hasDbXref "MFMO:0000072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018544 ; owl:annotatedTarget "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." . [] oboInOwl:hasDbXref "MFMO:0000072" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018544 ; owl:annotatedTarget "muscles innervated by the trigeminal nerve" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "alpha-methylpropionic acid" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-60327-246-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002352 ; owl:annotatedTarget "A hematopoietic stem cell that exists during embryogenesis." . [] oboInOwl:hasDbXref "FMA:84201" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018550 ; owl:annotatedTarget "permanent incisor tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018561 ; owl:annotatedTarget "A secondary canine tooth that is part of a upper jaw region." . [] oboInOwl:hasDbXref "FMA:55714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018561 ; owl:annotatedTarget "maxillary secondary canine tooth" . [] oboInOwl:hasDbXref "FMA:55714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018561 ; owl:annotatedTarget "upper permanent canine tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018561 ; owl:annotatedTarget "C" . [] oboInOwl:hasDbXref "FMA:55714" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018561 ; owl:annotatedTarget "permanent upper canine tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018562 ; owl:annotatedTarget "A secondary canine tooth that is part of a lower jaw region." . [] oboInOwl:hasDbXref "FMA:55715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018562 ; owl:annotatedTarget "lower permanent canine tooth" . [] oboInOwl:hasDbXref "FMA:55715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018562 ; owl:annotatedTarget "mandibular secondary canine tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018562 ; owl:annotatedTarget "c" . [] oboInOwl:hasDbXref "FMA:55715" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018562 ; owl:annotatedTarget "permanent lower canine tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018568 ; owl:annotatedTarget "A lower jaw incisor that is in_the_central_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:55723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018568 ; owl:annotatedTarget "lower central permanent incisor tooth" . [] oboInOwl:hasDbXref "FMA:55723" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018568 ; owl:annotatedTarget "mandibular central secondary incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018568 ; owl:annotatedTarget "i1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018570 ; owl:annotatedTarget "A lower jaw incisor that is in_the_lateral_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:55725" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018570 ; owl:annotatedTarget "lower lateral permanent incisor tooth" . [] oboInOwl:hasDbXref "FMA:55725" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018570 ; owl:annotatedTarget "mandibular lateral secondary incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018570 ; owl:annotatedTarget "i2" . [] oboInOwl:hasDbXref "FMA:55811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018575 ; owl:annotatedTarget "maxillary first secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018575 ; owl:annotatedTarget "upper first permanent molar tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018575 ; owl:annotatedTarget "M1" . [] oboInOwl:hasDbXref "FMA:55812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018576 ; owl:annotatedTarget "maxillary second secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55812" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018576 ; owl:annotatedTarget "upper second permanent tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018576 ; owl:annotatedTarget "M2" . [] oboInOwl:hasDbXref "FMA:55814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018578 ; owl:annotatedTarget "lower first permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:55814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018578 ; owl:annotatedTarget "mandibular first secondary molar tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018578 ; owl:annotatedTarget "m1" . [] oboInOwl:hasDbXref "FMA:55815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018579 ; owl:annotatedTarget "lower second permanent molar tooth" . [] oboInOwl:hasDbXref "FMA:55815" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018579 ; owl:annotatedTarget "mandibular second secondary molar tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018579 ; owl:annotatedTarget "m2" . [] oboInOwl:hasDbXref "FMA:84202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018583 ; owl:annotatedTarget "deciduous canine tooth" . [] oboInOwl:hasDbXref "FMA:84202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018583 ; owl:annotatedTarget "primary tooth C" . [] oboInOwl:hasDbXref "FMA:84202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018583 ; owl:annotatedTarget "temporary canine tooth" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "iso-C3H7COOH" . [] oboInOwl:hasDbXref "FMA:84203" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018584 ; owl:annotatedTarget "permanent canine tooth" . [] oboInOwl:hasDbXref "FMA:84211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018588 ; owl:annotatedTarget "upper first deciduous molar tooth" . [] oboInOwl:hasDbXref "FMA:84211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018588 ; owl:annotatedTarget "upper primary tooth D" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018588 ; owl:annotatedTarget "dM1" . [] oboInOwl:hasDbXref "FMA:84212" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018589 ; owl:annotatedTarget "lower first deciduous molar tooth" . [] oboInOwl:hasDbXref "FMA:84212" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018589 ; owl:annotatedTarget "lower primary tooth D" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018589 ; owl:annotatedTarget "dm1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018591 ; owl:annotatedTarget "A primary incisor tooth that is part of a upper jaw region." . [] oboInOwl:hasDbXref "FMA:84214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018591 ; owl:annotatedTarget "upper deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84214" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018591 ; owl:annotatedTarget "deciduous upper incisor tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018593 ; owl:annotatedTarget "A upper primary canine tooth that is in_the_central_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:84216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018593 ; owl:annotatedTarget "upper central deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84216" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018593 ; owl:annotatedTarget "upper primary tooth A" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018593 ; owl:annotatedTarget "dI1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018594 ; owl:annotatedTarget "A upper primary canine tooth that is in_the_lateral_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:84217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018594 ; owl:annotatedTarget "upper lateral deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84217" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018594 ; owl:annotatedTarget "upper primary tooth B" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018594 ; owl:annotatedTarget "dI2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018595 ; owl:annotatedTarget "A lower primary incisor tooth that is in_the_central_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:84218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018595 ; owl:annotatedTarget "lower central deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018595 ; owl:annotatedTarget "lower primary tooth A" . [] oboInOwl:hasDbXref "FMA:84218" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018595 ; owl:annotatedTarget "deciduous lower central incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018595 ; owl:annotatedTarget "di1" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018596 ; owl:annotatedTarget "A lower primary incisor tooth that is in_the_lateral_side_of a dentition." . [] oboInOwl:hasDbXref "FMA:84219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018596 ; owl:annotatedTarget "lower lateral deciduous incisor tooth" . [] oboInOwl:hasDbXref "FMA:84219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018596 ; owl:annotatedTarget "lower primary tooth B" . [] oboInOwl:hasDbXref "FMA:84219" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018596 ; owl:annotatedTarget "deciduous lower lateral incisor tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018596 ; owl:annotatedTarget "di2" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018597 ; owl:annotatedTarget "A primary canine tooth that is part of a upper jaw region." . [] oboInOwl:hasDbXref "FMA:84228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018597 ; owl:annotatedTarget "upper deciduous canine tooth" . [] oboInOwl:hasDbXref "FMA:84228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018597 ; owl:annotatedTarget "upper primary tooth C" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018597 ; owl:annotatedTarget "dC" . [] oboInOwl:hasDbXref "FMA:84228" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018597 ; owl:annotatedTarget "deciduous upper canine tooth" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018598 ; owl:annotatedTarget "A primary canine tooth that is part of a lower jaw region." . [] oboInOwl:hasDbXref "FMA:84229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018598 ; owl:annotatedTarget "lower deciduous canine tooth" . [] oboInOwl:hasDbXref "FMA:84229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018598 ; owl:annotatedTarget "lower primary tooth C" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018598 ; owl:annotatedTarget "dc" . [] oboInOwl:hasDbXref "FMA:84229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018598 ; owl:annotatedTarget "deciduous lower canine tooth" . [] oboInOwl:hasDbXref "FMA:84236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018599 ; owl:annotatedTarget "upper primary tooth E" . [] oboInOwl:hasDbXref "FMA:84236" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018599 ; owl:annotatedTarget "upper second deciduous molar tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018599 ; owl:annotatedTarget "dM2" . [] oboInOwl:hasDbXref "FMA:84237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018600 ; owl:annotatedTarget "lower primary tooth E" . [] oboInOwl:hasDbXref "FMA:84237" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018600 ; owl:annotatedTarget "lower second deciduous molar tooth" . [] oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018600 ; owl:annotatedTarget "dm2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "iso-butyric acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002353 ; owl:annotatedTarget obo:CL_0002352 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018601 ; owl:annotatedTarget "An incisor tooth that is in_the_central_side_of a dentition and is part of a lower jaw region." . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-1-60327-346-6", "PMID:16569764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002353 ; owl:annotatedTarget "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018602 ; owl:annotatedTarget "An incisor tooth that is in_the_lateral_side_of a dentition and is part of a lower jaw region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018603 ; owl:annotatedTarget "An incisor tooth that is in_the_central_side_of a dentition and is part of a upper jaw region." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018604 ; owl:annotatedTarget "An incisor tooth that is in_the_lateral_side_of a dentition and is part of a upper jaw region." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018606 ; owl:annotatedTarget "The molar tooth of the upper or lower jaw that is phylogenetically number 2." . [] oboInOwl:hasDbXref "FMA:55713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018623 ; owl:annotatedTarget "lower permanent incisor tooth" . [] oboInOwl:hasDbXref "FMA:55713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018623 ; owl:annotatedTarget "mandibular secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55713" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018623 ; owl:annotatedTarget "permanent lower incisor tooth" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018645 ; owl:annotatedTarget "The subdivision of the dentition that consists entire of incisor teeth." . _:genid157585 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002082, obo:UBERON_0006717 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018649 ; owl:annotatedTarget "ventricular cardiac muscle tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018649 ; owl:annotatedTarget "ventricular heart muscle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0018649 ; owl:annotatedTarget "ventricular muscle" . [] oboInOwl:notes "https://github.com/obophenotype/uberon/wiki/Hidden-GCIs" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018664 ; owl:annotatedTarget obo:UBERON_0005913 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018664 ; owl:annotatedTarget "The neck region of a bone organ." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "isobutanoic acid" . [] oboInOwl:hasDbXref "FMA:23254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018667 ; owl:annotatedTarget "anatomical neck of scapula" . _:genid157602 oboInOwl:hasDbXref "FMA:23254" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018667 ; owl:annotatedTarget "scapular neck" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009880 . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0018673 ; owl:annotatedTarget "EMAPA:37891" . [] oboInOwl:hasDbXref "FMA:35508" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018673 ; owl:annotatedTarget "fibula neck" . [] oboInOwl:hasDbXref "ZFA:0005811", "ZFA:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018674 ; owl:annotatedTarget "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." . [] oboInOwl:hasDbXref "FMA:73747" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0018674 ; owl:annotatedTarget "cardiac vasculature" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0018679 ; owl:annotatedTarget _:genid159865 . [] oboInOwl:hasDbXref "Wikipedia:Thoracic_splanchnic_nerves" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018679 ; owl:annotatedTarget "Thoracic splanchnic nerves are splanchnic nerves that arise from the sympathetic trunk in the thorax and travel inferiorly to provide sympathetic innervation to the abdomen. The nerves contain preganglionic sympathetic and general visceral afferent fibers." . [] oboInOwl:hasDbXref "BTO:0000123" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0018707 ; owl:annotatedTarget "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." . [] oboInOwl:hasDbXref "BTO:0000123" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0018707 ; owl:annotatedTarget "bladder" . [] oboInOwl:hasDbXref "BTO:0002439" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019042 ; owl:annotatedTarget "genital mucosa" . [] oboInOwl:hasDbXref "BTO:0004043" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019143 ; owl:annotatedTarget "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." . [] oboInOwl:hasDbXref "BTO:0004043" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019143 ; owl:annotatedTarget "intramuscular fat" . [] oboInOwl:hasDbXref "BTO:0004626" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019189 ; owl:annotatedTarget "carotid endothelium" . [] oboInOwl:hasDbXref "FMA:13119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019190 ; owl:annotatedTarget "bronchial gland" . [] oboInOwl:hasDbXref "FMA:13119" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019190 ; owl:annotatedTarget "bronchial mucous gland" . [] oboInOwl:hasDbXref "BTO:0004638" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019190 ; owl:annotatedTarget "peribronchial gland" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002354 ; owl:annotatedTarget obo:CL_0002352 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget _:genid159924 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nerve_of_the_penis", "http://medical-dictionary.thefreedictionary.com/dorsal%20nerve%20of%20penis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget "The deep terminal division of the pudendal nerve that runs along the dorsum of the penis and innervates the the corpus cavernosum penis, the prepuce and the glans penis." . [] oboInOwl:hasDbXref "FMA:21869" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget "nervus dorsalis penis" . [] oboInOwl:hasDbXref "GOC:tfm", "doi:10.1097/MOH.0b013e3282f97ae1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002354 ; owl:annotatedTarget "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." . [] oboInOwl:hasDbXref "FMA:21869", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget "nervus dorsalis penis " . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nerve_of_the_penis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget "dorsal nerve of penis" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nerve_of_the_penis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019197 ; owl:annotatedTarget "dorsal nerves of the penis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0019198 ; owl:annotatedTarget _:genid159939 . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nerve_of_clitoris", "http://medical-dictionary.thefreedictionary.com/dorsal%20nerve%20of%20clitoris" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019198 ; owl:annotatedTarget "The deep terminal division of the pudendal nerve that runs along the dorsum of the clitoral shaft and innervates the the glans clitoris." . [] oboInOwl:hasDbXref "FMA:21870" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019198 ; owl:annotatedTarget "nervus dorsalis clitoridis" . [] oboInOwl:hasDbXref "Wikipedia:Dorsal_nerve_of_clitoris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019198 ; owl:annotatedTarget "dorsal nerve of the clitoris" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019200 ; owl:annotatedTarget "Zone of skin that is part of the anterior region of the chest." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16135 ; owl:annotatedTarget "isopropylformic acid" . [] oboInOwl:hasDbXref "FMA:10461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019200 ; owl:annotatedTarget "anterior chest skin" . [] oboInOwl:hasDbXref "FMA:10461" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019200 ; owl:annotatedTarget "skin of anterior part of thorax" . [] oboInOwl:hasDbXref "HP:0007542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019200 ; owl:annotatedTarget "skin of ventral chest" . [] oboInOwl:hasDbXref "HP:0007542" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019200 ; owl:annotatedTarget "ventral chest skin" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019204 ; owl:annotatedTarget "Any region of epithelium that is part of a skin region." . [] oboInOwl:hasDbXref "UBERON:drseb", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019207 ; owl:annotatedTarget "The part of the eye that consists of both the retina and the optic choroid." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0019210 ; owl:annotatedTarget obo:UBERON_0034944 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019210 ; owl:annotatedTarget "A central point or region on the anterior or posterior surface of the lens." . _:genid157720 oboInOwl:hasDbXref "FMA:58067" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019210 ; owl:annotatedTarget "lens zone" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0009879 . [] oboInOwl:hasDbXref "FMA:58067" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019210 ; owl:annotatedTarget "zone of lens" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019221 ; owl:annotatedTarget "Either of the outermost digits in a five-digit autopod, or their phylogenetic equivalent." . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019221 ; owl:annotatedTarget "lateral digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019221 ; owl:annotatedTarget "outer digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019221 ; owl:annotatedTarget "outermost digit" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-1-60327-346-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002359 ; owl:annotatedTarget "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019222 ; owl:annotatedTarget "Any of the three medial digits in a five-digit autopod, or their phylogenetic equivalent." . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019222 ; owl:annotatedTarget "medial digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019222 ; owl:annotatedTarget "mesoaxial digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019231 ; owl:annotatedTarget "lateral finger" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019231 ; owl:annotatedTarget "lateral manual digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019231 ; owl:annotatedTarget "outer manual digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019231 ; owl:annotatedTarget "outermost manual digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019232 ; owl:annotatedTarget "medial manual digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019232 ; owl:annotatedTarget "mesoaxial manual digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019232 ; owl:annotatedTarget "mesoxaxial finger" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019241 ; owl:annotatedTarget "lateral pedal digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019241 ; owl:annotatedTarget "lateral toe" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019241 ; owl:annotatedTarget "outer pedal digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019241 ; owl:annotatedTarget "outermost pedal digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019242 ; owl:annotatedTarget "medial pedal digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019242 ; owl:annotatedTarget "mesoaxial pedal digit" . [] oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019242 ; owl:annotatedTarget "mesoxaxial ftoe" . [] oboInOwl:hasDbXref "FMA:55712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019253 ; owl:annotatedTarget "maxillary secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019253 ; owl:annotatedTarget "upper permanent incisor tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002363 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "FMA:59408" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019254 ; owl:annotatedTarget "eyelash of upper eyelid" . [] oboInOwl:hasDbXref "FMA:59408" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019254 ; owl:annotatedTarget "upper eyelid eyelash" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019254 ; owl:annotatedTarget "upper eyelid cilia" . [] oboInOwl:hasDbXref "FMA:59409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019255 ; owl:annotatedTarget "eyelash of lower eyelid" . [] oboInOwl:hasDbXref "FMA:59409" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019255 ; owl:annotatedTarget "lower eyelid eyelash" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0019255 ; owl:annotatedTarget "lower eyelid cilia" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:978-0-7020-2958-5" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002363 ; owl:annotatedTarget "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019258 ; owl:annotatedTarget "A white matter that is part of the hindbrain." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019261 ; owl:annotatedTarget "A white matter that is part of the forebrain." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019262 ; owl:annotatedTarget "A white matter that is part of the myelencephalon." . [] oboInOwl:hasDbXref "HBA:MYWM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019262 ; owl:annotatedTarget "myelencephalic white matter" . [] oboInOwl:hasDbXref "DHBA:HGM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019263 ; owl:annotatedTarget "gray matter of the hindbrain" . _:genid157839 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000988, obo:UBERON_0002348 . [] oboInOwl:hasDbXref "HBA:PoWM" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019293 ; owl:annotatedTarget "pontine white matter tracts" . [] oboInOwl:hasDbXref "BIRNLEX:1069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019293 ; owl:annotatedTarget "predominantly white regional part of pontine tegmentum" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019293 ; owl:annotatedTarget "substantia alba tegmenti pontis" . [] oboInOwl:hasDbXref "FMA:83942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019293 ; owl:annotatedTarget "white matter of pontile tegmentum" . [] oboInOwl:hasDbXref "FMA:83942" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019293 ; owl:annotatedTarget "white substance of pontile tegmentum" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18403190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002364 ; owl:annotatedTarget "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." . [] oboInOwl:hasDbXref "HBA:TELCom" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019294 ; owl:annotatedTarget "telencephalic commissures" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0019307 ; owl:annotatedTarget obo:UBERON_0012329 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019307 ; owl:annotatedTarget "Epithelial layer that is part of the external part of the nose." . [] oboInOwl:hasDbXref "FMA:63143" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019307 ; owl:annotatedTarget "epithelium of skin of external nose" . [] oboInOwl:hasDbXref "PMID:20664693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019315 ; owl:annotatedTarget "An oily substance that prevents evaporation of the eye's tear film." . [] oboInOwl:hasDbXref "GOC:dos", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0019319 ; owl:annotatedTarget "An exocrine gland that is part of a integumental system." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019319 ; owl:annotatedTarget "integumental exocrine gland" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0019319 ; owl:annotatedTarget "integumental system exocrine gland" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget obo:UBERON_0000126 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget obo:UBERON_0006331 . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget _:genid160136 . [] oboInOwl:hasDbXref "Wikipedia:Spinal_accessory_nucleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "EMAPA:37067" . [] oboInOwl:hasDbXref "FMA:83965" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "accessory neural nucleus" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "accessory nucleus of anterior column of spinal cord" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "nucleus accessorius columnae anterioris medullae spinalis" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "nucleus nervi accessorii" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "nucleus of accessory nerve" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "nucleus of the accessory nerve" . [] oboInOwl:hasDbXref "NeuroNames:2003" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "nucleus of the spinal accessory nerve" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0020358 ; owl:annotatedTarget "spinal accessory nucleus" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18180458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002365 ; owl:annotatedTarget "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0020550 ; owl:annotatedTarget "A blood vessel that supplies or drains an ear." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0020550 ; owl:annotatedTarget "EMAPA:37386" . [] oboInOwl:hasDbXref "FMA:62444" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022235 ; owl:annotatedTarget "diencephalon peduncle" . _:genid157913 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001019 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001893 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 . [] oboInOwl:hasDbXref "FMA:260712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022248 ; owl:annotatedTarget "cerebral fascicle" . [] oboInOwl:hasDbXref "FMA:260712" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022248 ; owl:annotatedTarget "cerebral fasciculus" . _:genid157921 a owl:Restriction ; owl:onProperty obo:BFO_0000050, core:extends_fibers_into ; owl:someValuesFrom obo:UBERON_0005908, obo:UBERON_0011390 . [] oboInOwl:hasDbXref "Wikipedia:Onuf%27s_nucleus", "Wikipedia:Pudendal_nerve#Nucleus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022278 ; owl:annotatedTarget "A nucleus in the ventral part of the anterior horn of the sacral region of the spinal cord that is the origin of the pudendal nerve." . [] oboInOwl:hasDbXref "FMA:77024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022278 ; owl:annotatedTarget "Onuf's nucleus" . [] oboInOwl:hasDbXref "FMA:257031" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022278 ; owl:annotatedTarget "nucleus of Onuf" . [] oboInOwl:hasDbXref "FMA:77024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022278 ; owl:annotatedTarget "pudendal neural nucleus" . [] oboInOwl:hasDbXref "FMA:53671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022279 ; owl:annotatedTarget "hair of external ear" . [] oboInOwl:hasDbXref "FMA:53671" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022279 ; owl:annotatedTarget "hair of tragus" . _:genid157935 oboInOwl:hasDbXref "FMA:53671" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022279 ; owl:annotatedTarget "tragus hair" ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001602 . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022284 ; owl:annotatedTarget "The single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland)." . [] oboInOwl:notes "primarily aqueous layer" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0022287 ; owl:annotatedTarget _:genid160191 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022287 ; owl:annotatedTarget "An aqueous substance that covers the anterior surface of the eyeball, keeping the cornea wet." . [] oboInOwl:source "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0022287 ; owl:annotatedTarget "the thin acellular fluid layer that adheres to the most superficial layer of the corneal epithelium and lubricates and protects the ocular surface; the film is generally composed of three layers: (i) an inner mucous layer, secreted largely by the conjunctival goblet cells with contributions from the lacrimal glands, which coats the cornea, provides a hydrophobic layer, and allows for even distribution of the tear film; (ii) a middle aqueous layer, secreted by the lacrimal glands, which keeps the corneal surface moist, and provides a mechanism for oxygenation and nutrient exchange with the avascular anterior corneal tissue; and (iii) an outer lipid layer, secreted principally by the Meibomian (tarsal) glands although lipid tear elements also are contributed by the Harderian glands; tear film lipids form a monolayer on the tear surface, and function by enhancing the surface tension which supports the integrity of the tear film against collapse due to gravity and also slows down the loss of the tear film by evaporation; in addition , the lipid layer provides a glassy, smooth interface between the air and the transparent cornea" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022287 ; owl:annotatedTarget "precorneal film" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002367 ; owl:annotatedTarget obo:CL_0000115 . [] oboInOwl:hasDbXref "FMA:58315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0022288 ; owl:annotatedTarget "surface of region of wall of eyeball" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022293 ; owl:annotatedTarget "A portion of organism substance that is secreted by a reproductive gland." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:14500801" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002367 ; owl:annotatedTarget "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0022296 ; owl:annotatedTarget _:genid160211 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022296 ; owl:annotatedTarget "A nerve that innervates a lower eyelid and is a branch of the infra-orbital branch of the maxillary nerve." . [] oboInOwl:hasDbXref "Wikipedia:Inferior_palpebral_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022296 ; owl:annotatedTarget "rami palpebrales inferiores nervi infraorbitalis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0022297 ; owl:annotatedTarget _:genid160220 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022297 ; owl:annotatedTarget "A nerve that innervates an eyelid and is a branch of the infra-orbital branch of the maxillary nerve." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022298 ; owl:annotatedTarget "A nerve that innervates a lower eyelid." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022299 ; owl:annotatedTarget "A nerve that innervates an upper eyelid." . [] oboInOwl:hasDbXref "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/long+ciliary+nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022302 ; owl:annotatedTarget "A branch of the ciliary ganglion that innervates the ciliary muscles, the iris, and the tunics of the eyeball." . [] oboInOwl:hasDbXref "FMA:7041" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022302 ; owl:annotatedTarget "lower branch of ciliary ganglion" . [] oboInOwl:hasDbXref "Wikipedia:Short_ciliary_nerves" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0022302 ; owl:annotatedTarget "nervi ciliares breves" . [] oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0022302 ; owl:annotatedTarget "nervi ciliares brevis" . [] oboInOwl:hasDbXref "Wikipedia:Short_ciliary_nerves" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0022302 ; owl:annotatedTarget "short ciliary nerve" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16137 ; owl:annotatedTarget "Chondroitin" . [] oboInOwl:hasDbXref "NLX:149357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022303 ; owl:annotatedTarget "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." . [] oboInOwl:hasDbXref "CUMBO:CUMBO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0022303 ; owl:annotatedTarget "lamina" . [] oboInOwl:hasDbXref "CUMBO:CUMBO" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0022303 ; owl:annotatedTarget "layer" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002368 ; owl:annotatedTarget obo:CL_0002076 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022350 ; owl:annotatedTarget "Serous membrane layer that is adjacent to and lines an organ." . [] oboInOwl:hasDbXref "FMA:15860" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022350 ; owl:annotatedTarget "visceral wall of serous membrane" . _:genid158017 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0004923 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000042 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0002553 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001899 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002368 ; owl:annotatedTarget "An endo-epithelial cell of the respiratory tract." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022351 ; owl:annotatedTarget "Serous membrane layer that lines to a body cavity." . [] oboInOwl:hasDbXref "MA:0002448" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0022351 ; owl:annotatedTarget "cavity lining" . [] oboInOwl:hasDbXref "FMA:15859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022351 ; owl:annotatedTarget "parietal wall of serous membrane" . [] oboInOwl:hasDbXref "Wikipedia:Endometrium#Histology" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022355 ; owl:annotatedTarget "The layer of endometrial epithelium adjacent to the uterine cavity." . [] oboInOwl:hasDbXref "FMA:86492" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022355 ; owl:annotatedTarget "stratum basalis of endometrium" . [] oboInOwl:hasDbXref "FMA:14652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022357 ; owl:annotatedTarget "ileal mesentery" . [] oboInOwl:hasDbXref "FMA:14652" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0022357 ; owl:annotatedTarget "ileum mesentery" . [] oboInOwl:hasDbXref "GO:0060674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022358 ; owl:annotatedTarget "A blood vessel of the placenta." . _:genid158043 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0001765 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003570 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022360 ; owl:annotatedTarget "A mammary gland duct that is part of a male organism. This structure typically regresses." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0022361 ; owl:annotatedTarget "A specific region of the foregut into the area in which the lung will develop." . [] oboInOwl:hasDbXref "NLXANAT:090802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0023879 ; owl:annotatedTarget "A set of neural structures that subserve a specific function, e.g., visual system." . [] oboInOwl:hasDbXref "NLXANAT:090802" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0023879 ; owl:annotatedTarget "neural system" . [] oboInOwl:hasDbXref "NLXANAT:20081249" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0024045 ; owl:annotatedTarget "White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei." . [] oboInOwl:hasDbXref "NLXANAT:20081249" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0024045 ; owl:annotatedTarget "white matter of the cerebellar cortex" . [] oboInOwl:hasDbXref "BIRNLEX:749" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0025261 ; owl:annotatedTarget "thalamic fiber tracts" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0025525 ; owl:annotatedTarget obo:UBERON_0023879 . [] oboInOwl:hasDbXref "Wikipedia:Motor_system" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0025525 ; owl:annotatedTarget "The part of the central nervous system that is involved with movement." . [] oboInOwl:hasDbXref "NLXANAT:090805" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0025525 ; owl:annotatedTarget "motor system" . [] oboInOwl:hasDbXref "NLXANAT:090814" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0025533 ; owl:annotatedTarget "The sensory system for the sense of proprioception." . [] oboInOwl:hasDbXref "NLXANAT:090814" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0025533 ; owl:annotatedTarget "proprioceptive system" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0026246 ; owl:annotatedTarget obo:UBERON_0029503 . [] oboInOwl:hasDbXref "BIRNLEX:1500" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0026246 ; owl:annotatedTarget "sacral spinal cord white matter" . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0026386 ; owl:annotatedTarget obo:UBERON_0029636 . [] oboInOwl:hasDbXref "BIRNLEX:1639" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0026386 ; owl:annotatedTarget "lumbar spinal cord white matter" . [] oboInOwl:hasDbXref "MP:0010863" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002370 ; owl:annotatedTarget "respiratory mucosa goblet cells" . [] oboInOwl:hasDbXref "BIRNLEX:1491" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0029503 ; owl:annotatedTarget "sacral spinal cord gray matter" . [] oboInOwl:hasDbXref "BIRNLEX:1624" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0029636 ; owl:annotatedTarget "lumbar spinal cord gray matter" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16137 ; owl:annotatedTarget "Chondroitin-D-glucuronate" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002371 ; owl:annotatedTarget "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." . [] oboInOwl:hasDbXref "BIRNLEX:891" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0030276 ; owl:annotatedTarget "lumbar spinal cord ventral horn" . [] oboInOwl:hasDbXref "BIRNLEX:891" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0030276 ; owl:annotatedTarget "lumbar spinal cord anterior horn" . ( ) . [] oboInOwl:hasDbXref "BIRNLEX:1457" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0032748 ; owl:annotatedTarget "sacral spinal cord ventral horn" . [] oboInOwl:hasDbXref "BIRNLEX:1457" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0032748 ; owl:annotatedTarget "sacral spinal cord anterior horn" . [] oboInOwl:hasDbXref "DOI:10.1523/JNEUROSCI.5142-05.2006", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034670 ; owl:annotatedTarget "A taste bud that is located on the soft palate, in the roof of the mouth." . _:genid158119 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000062 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0071625 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001115 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034681 ; owl:annotatedTarget "Any organ that is the primary organ of vocalization behavior. Examples: The laryngeal vocal cord (humans), the syrinx (birds)." . [] oboInOwl:hasDbXref "AEO:0001008", "AEO:JB" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034705 ; owl:annotatedTarget "An embryonic or larval epithelium that is committed to form part of the nervous system." . [] oboInOwl:hasDbXref "BTO:0000314" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0034705 ; owl:annotatedTarget "neurepithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034705 ; owl:annotatedTarget "embryonic neuroepithelium" . [] oboInOwl:hasDbXref "AEO:0001008" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034705 ; owl:annotatedTarget "neuroepithelium" . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034706 ; owl:annotatedTarget obo:UBERON_0034705 . [] oboInOwl:hasDbXref "AEO:0001009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034706 ; owl:annotatedTarget "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." . _:genid158131 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BFO_0000051 ; owl:someValuesFrom obo:CL_0000031, obo:UBERON_0001114 . [] oboInOwl:source "AEO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034707 ; owl:annotatedTarget obo:UBERON_0034705 . [] oboInOwl:hasDbXref "AEO:0001010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034707 ; owl:annotatedTarget "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." . [] oboInOwl:hasDbXref "DHBA:12695" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034708 ; owl:annotatedTarget "marginal zone of cerebellum" . [] oboInOwl:hasDbXref "DHBA:12695" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034708 ; owl:annotatedTarget "MZCB" . [] oboInOwl:hasDbXref "DHBA:12694" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034709 ; owl:annotatedTarget "marginal zone of hindbrain" . [] oboInOwl:hasDbXref "DHBA:12694" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034709 ; owl:annotatedTarget "MZH" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034710 ; owl:annotatedTarget _:genid160403 . [] oboInOwl:hasDbXref "EHDAA2:0001267" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034710 ; owl:annotatedTarget "spinal cord lateral wall ventricular layer" . [] oboInOwl:hasDbXref "PMID:12626695" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034711 ; owl:annotatedTarget "The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate." . [] oboInOwl:hasDbXref "ISBN:0471888893", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034713 ; owl:annotatedTarget "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034713 ; owl:annotatedTarget "cranial nerve fiber bundle" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034713 ; owl:annotatedTarget "cranial nerve fiber tract" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034713 ; owl:annotatedTarget "cranial nerve or tract" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034713 ; owl:annotatedTarget "neuron projection bundle from brain" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034714 ; owl:annotatedTarget "A cranial nerve fiber tract that innervates the parietal eye." . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034714 ; owl:annotatedTarget "epiphyseal nerve" . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034715 ; owl:annotatedTarget "A cranial nerve fiber tract that innervates the pineal body." . [] oboInOwl:hasDbXref "ISBN:0471888893" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034715 ; owl:annotatedTarget "pineal nerve" . [] oboInOwl:hasDbXref "PMID:11921337", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034717 ; owl:annotatedTarget "A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish." . [] oboInOwl:hasDbXref "PMID:11921337", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034719 ; owl:annotatedTarget "A taste bud that is located on a lip." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002372 ; owl:annotatedTarget "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034720 ; owl:annotatedTarget "A taste bud that is located on the skin of the head." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034721 ; owl:annotatedTarget "A taste bud that is located in the pharynx." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034722 ; owl:annotatedTarget "A taste bud that is located on the roof of the mouth." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034724 ; owl:annotatedTarget "A taste bud that is located in the esophagus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034726 ; owl:annotatedTarget "A taste bud that is located on the skin of the trunk." . [] oboInOwl:hasDbXref "Wikipedia:Autonomic_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034728 ; owl:annotatedTarget "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0034728 ; owl:annotatedTarget "EMAPA:37957" . [] oboInOwl:hasDbXref "FMA:5866" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034728 ; owl:annotatedTarget "nervus visceralis" . [] oboInOwl:hasDbXref "FMA:5866" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034728 ; owl:annotatedTarget "visceral nerve" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0034729 ; owl:annotatedTarget "EMAPA:37958" . [] oboInOwl:source "ZFA:0000229" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0034730 ; owl:annotatedTarget "Telencephalic white matter which extends between the olfactory bulb and the ipsilateral dorsal telencephalon and carries secondary olfactory fibers. From Neuroanatomy of the Zebrafish Brain." . [] oboInOwl:hasDbXref "ZFA:0000229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034730 ; owl:annotatedTarget "lateral olfactory tract" . [] oboInOwl:hasDbXref "ZFA:0000229" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034730 ; owl:annotatedTarget "tractus olfactorius lateralis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034736 ; owl:annotatedTarget _:genid160493 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034736 ; owl:annotatedTarget "Any ligament that connects the coracoid process with the clavicle." . [] oboInOwl:hasDbXref "FMA:26029" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034736 ; owl:annotatedTarget "accessory ligament of acromioclavicular joint" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034762 ; owl:annotatedTarget obo:UBERON_0000382 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034762 ; owl:annotatedTarget "Any sweat gland that is part of an areola." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034762 ; owl:annotatedTarget "areolar aprocine sweat gland" . [] oboInOwl:hasDbXref "FMA:62149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034762 ; owl:annotatedTarget "sweat gland of areola" . _:genid158252 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002028, obo:UBERON_0008342 . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-090417-11", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034763 ; owl:annotatedTarget "Any commissure within the hindbrain." . [] oboInOwl:hasDbXref "Wikipedia:Glabella", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034765 ; owl:annotatedTarget "The zone of skin that overlaps with the glabella region." . [] oboInOwl:hasDbXref "Wikipedia:Glabella", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034766 ; owl:annotatedTarget "A region of the forehead corresponding to the space between the eyebrows and above the nose." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034768 ; owl:annotatedTarget "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034769 ; owl:annotatedTarget obo:UBERON_0015757 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034873 ; owl:annotatedTarget "Any substance in the body or expelled from the body that is in a gaseous state." . [] oboInOwl:hasDbXref "FMA:84580" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034873 ; owl:annotatedTarget "portion of gas in anatomical space" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034874 ; owl:annotatedTarget "Any portion of gas located in a part of the respiratory system that is composed primarily of air." . [] oboInOwl:hasDbXref "FMA:84581" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034874 ; owl:annotatedTarget "respiratory air" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034875 ; owl:annotatedTarget _:genid160538 . [] oboInOwl:source "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034875 ; owl:annotatedTarget _:genid160540 . [] oboInOwl:hasDbXref "EHDAA2:0001472" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034875 ; owl:annotatedTarget "pituitary primordium" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034876 ; owl:annotatedTarget _:genid160547 . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034876 ; owl:annotatedTarget _:genid160549 . [] oboInOwl:hasDbXref "MP:0013339", "https://sourceforge.net/p/obo/mammalian-phenotype-requests/1930/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034876 ; owl:annotatedTarget "The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland." . [] oboInOwl:hasDbXref "EHDAA2:0004434" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034876 ; owl:annotatedTarget "neurohypohysial region" . [] oboInOwl:hasDbXref "MP:0013339" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034876 ; owl:annotatedTarget "neurohypophyseal bud" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16180 ; owl:annotatedTarget "N-Acylglycine" . [] oboInOwl:hasDbXref "MGI:anna" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034878 ; owl:annotatedTarget "The area of axial mesoderm that develops into the prechordal plate." . [] oboInOwl:source "AAO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034898 ; owl:annotatedTarget _:genid160565 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034898 ; owl:annotatedTarget "The thickened ridge of bone that contains the tooth sockets on the premaxilla." . [] oboInOwl:hasDbXref "AAO:0000397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034898 ; owl:annotatedTarget "pars dentalis of premaxilla" . [] oboInOwl:hasDbXref "Wikipedia:Cervical_ganglia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034901 ; owl:annotatedTarget "The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. These emerging postganglionic nerves synapse with preganglionic nerves from the thoracic spinal cord. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things." . [] oboInOwl:hasDbXref "FMA:6261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034901 ; owl:annotatedTarget "cervical part of sympathetic trunk" . [] oboInOwl:hasDbXref "FMA:6261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034901 ; owl:annotatedTarget "cervical sympathetic chain" . [] oboInOwl:hasDbXref "FMA:6261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034901 ; owl:annotatedTarget "cervical sympathetic trunk" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0034902 ; owl:annotatedTarget "EMAPA:37656" . [] oboInOwl:hasDbXref "FMA:6264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034902 ; owl:annotatedTarget "sacral part of sympathetic trunk" . [] oboInOwl:hasDbXref "FMA:6264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034902 ; owl:annotatedTarget "sacral sympathetic chain" . [] oboInOwl:hasDbXref "FMA:6264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034902 ; owl:annotatedTarget "sacral sympathetic trunk" . [] oboInOwl:hasDbXref "MA:0001164" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034902 ; owl:annotatedTarget "pelvic sympathetic nerve trunk" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:20870168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002393 ; owl:annotatedTarget "A monocyte that has characteristics of both patrolling and inflammatory monocytes." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034903 ; owl:annotatedTarget "Endocardium that is part of the left atrium." . [] oboInOwl:source "FMA:7286" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000001 ; owl:annotatedSource obo:UBERON_0034903 ; owl:annotatedTarget "Endocardium of atrium which is continuous with the tunica intima of the trunk of pulmonary vein." . [] oboInOwl:hasDbXref "FMA:7286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034903 ; owl:annotatedTarget "endocardium of left atrium" . [] oboInOwl:hasDbXref "VHOG:0001226" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034903 ; owl:annotatedTarget "left atrium endocardial tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034907 ; owl:annotatedTarget "Parenchymal tissue that forms the pineal gland." . [] oboInOwl:hasDbXref "HPO:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034908 ; owl:annotatedTarget "Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." . _:genid158348 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0003685 [ a owl:Restriction ; owl:onClass obo:UBERON_0002397 ; owl:onProperty obo:RO_0002176 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom obo:GO_0050906 . [] oboInOwl:hasDbXref "http://www.researchgate.net/publication/255909975_Relationship_between_intermaxillary_suture_and_midline_diastema", "https://orcid.org/0000-0001-5889-4463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034909 ; owl:annotatedTarget "A cranial suture in the midline of the skull that connects the left and right maxilla bones." . [] oboInOwl:hasDbXref "FMA:52963" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034909 ; owl:annotatedTarget "intermaxillary suture of skull" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034921 ; owl:annotatedTarget obo:UBERON_0010000 . [] oboInOwl:hasDbXref "CARO:0020001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034921 ; owl:annotatedTarget "An multicellular anatomical structure that has subparts of multiple organs as a part." . [] oboInOwl:hasDbXref "CARO:0020001" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034921 ; owl:annotatedTarget "anatomical cluster" . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034922 ; owl:annotatedTarget obo:UBERON_0010000 . [] oboInOwl:hasDbXref "CARO:0020002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034922 ; owl:annotatedTarget "A cluster of cells, largely surrounded by a morphological boundary." . [] oboInOwl:source "CARO" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034923 ; owl:annotatedTarget obo:UBERON_0000465 . [] oboInOwl:hasDbXref "CARO:0020000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034923 ; owl:annotatedTarget "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034925 ; owl:annotatedTarget "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034926 ; owl:annotatedTarget "An anatomical collection that is arranged in a line." . [] oboInOwl:hasDbXref "FMA:19623" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034928 ; owl:annotatedTarget "dorsum of penis" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034928 ; owl:annotatedTarget "dorsum penis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034929 ; owl:annotatedTarget "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." . [] oboInOwl:hasDbXref "BTO:0001513", "MGI:cs", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034932 ; owl:annotatedTarget "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034932 ; owl:annotatedTarget "biliary system epithelium" . [] oboInOwl:hasDbXref "BTO:0001513" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034932 ; owl:annotatedTarget "biliary epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034932 ; owl:annotatedTarget "biliary tract epithelium" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034933 ; owl:annotatedTarget "Any organ component layer that consists of smooth muscle tissue." . [] oboInOwl:hasDbXref "GOC:YMB", "ZFA:0007073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034940 ; owl:annotatedTarget "An enlarged chamber in the blood sinus capable of accumulating a large volume of blood." . [] oboInOwl:hasDbXref "ZFA:0007073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034940 ; owl:annotatedTarget "blood sinus cavity" . [] oboInOwl:hasDbXref "ZFA:0007073" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034940 ; owl:annotatedTarget "blood sinus lumen" . [] oboInOwl:hasDbXref "FMA:55268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034944 ; owl:annotatedTarget "organ sector" . [] oboInOwl:hasDbXref "FMA:55268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034944 ; owl:annotatedTarget "organ zone" . [] oboInOwl:hasDbXref "FMA:55268" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0034944 ; owl:annotatedTarget "organ region with floating fiat boundary" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034945 ; owl:annotatedTarget "Any gaseous product of an excretory process." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034946 ; owl:annotatedTarget "Any excreted gas that is produced by the digestive tract." . [] oboInOwl:hasDbXref "FMA:78440" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0034946 ; owl:annotatedTarget "flatulence" . [] oboInOwl:hasDbXref "Wikipedia:Flatulence" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_0034946 ; owl:annotatedTarget "flatus" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034947 ; owl:annotatedTarget "Any portion of gas located in a part of the respiratory system." . ( ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034948 ; owl:annotatedTarget "Any portion of gas located in a part of the respiratory system that is composed primarily of carbon dioxide." . [] oboInOwl:source "VHOG" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0034953 ; owl:annotatedTarget _:genid160691 . [] oboInOwl:hasDbXref "DOI:10.1152/japplphysiol.00201.2013", "https://github.com/obophenotype/uberon/issues/1383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034953 ; owl:annotatedTarget "A population of lymphatic endothelial cell precursors that will form the lymph vessels." . _:genid158433 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000483 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000058 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001299 . _:genid158442 oboInOwl:hasDbXref "EMAPA:32917" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0034994 ; owl:annotatedTarget "hindbrain mantle layer" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001075 . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0034995 ; owl:annotatedTarget "Mesenchyme that is part of a developing jaw [Automatically generated definition]." . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035004 ; owl:annotatedTarget _:genid160709 . (obo:UBERON_0035004 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003101 ] ) . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035005 ; owl:annotatedTarget _:genid160715 . [] oboInOwl:hasDbXref "EMAPA:29220" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035005 ; owl:annotatedTarget "prepuce of male" . [] oboInOwl:source "EMAPA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035006 ; owl:annotatedTarget _:genid160722 . [] oboInOwl:hasDbXref "EMAPA:30478" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035006 ; owl:annotatedTarget "prepuce of female" . ( ) . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0035020 ; owl:annotatedTarget "EMAPA:37798" . [] oboInOwl:hasDbXref "FMA:18157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035020 ; owl:annotatedTarget "left vagus neural trunk" . [] oboInOwl:hasDbXref "FMA:18157" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035020 ; owl:annotatedTarget "trunk of left vagus" . [] oboInOwl:hasDbXref "MA:0001151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035020 ; owl:annotatedTarget "anterior vagus X nerve trunk" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0035021 ; owl:annotatedTarget "EMAPA:37799" . [] oboInOwl:hasDbXref "FMA:18151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035021 ; owl:annotatedTarget "right vagus neural trunk" . [] oboInOwl:hasDbXref "FMA:18151" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035021 ; owl:annotatedTarget "trunk of right vagus" . [] oboInOwl:hasDbXref "MA:0001152" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035021 ; owl:annotatedTarget "posterior vagus X nerve trunk" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035032 ; owl:annotatedTarget obo:UBERON_0002461 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035032 ; owl:annotatedTarget "Either the external or internal abdominal oblique muscles." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002395 ; owl:annotatedTarget obo:CL_0000860 . [] oboInOwl:hasDbXref "MA:0003024" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035032 ; owl:annotatedTarget "oblique abdominal muscle" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035034 ; owl:annotatedTarget "An epithelium that is part of an eyelid [Automatically generated definition]." . ( ) . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:8890901", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002395 ; owl:annotatedTarget "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035036 ; owl:annotatedTarget "An epithelium that is part of a naris [Automatically generated definition]." . [] oboInOwl:hasDbXref "Wikipedia:Carpal_tunnel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035038 ; owl:annotatedTarget "The fibro-osseous passageway on the palmar side of the wrist that connects the distal forearm to the middle compartment of the deep plane of the palm." . [] oboInOwl:hasDbXref "FMA:42352" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035038 ; owl:annotatedTarget "carpal canal" . [] oboInOwl:hasDbXref "Wikipedia:Carpal_tunnel" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035038 ; owl:annotatedTarget "carpel tunnel" . [] oboInOwl:hasDbXref "MP:0013746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035045 ; owl:annotatedTarget "Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts." . [] oboInOwl:hasDbXref "MP:0013750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035048 ; owl:annotatedTarget "Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product." . [] oboInOwl:hasDbXref "MP:0013750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035049 ; owl:annotatedTarget "Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized]." . [] oboInOwl:hasDbXref "FMA:70617" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035073 ; owl:annotatedTarget "ductal part of eccrine sweat gland" . [] oboInOwl:hasDbXref "FMA:70643" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035074 ; owl:annotatedTarget "ductal part of apocrine sweat gland" . [] oboInOwl:hasDbXref "MP:0013749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035078 ; owl:annotatedTarget "Any of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035083 ; owl:annotatedTarget "A vertebra that has a transverse process." . [] oboInOwl:hasDbXref "PMID:22753107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035083 ; owl:annotatedTarget "TP vertebra" . [] oboInOwl:hasDbXref "PMID:22753107" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035083 ; owl:annotatedTarget "pygal vertebra" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035091 ; owl:annotatedTarget "A post-anal tail that attaches outside the tail." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149", "PMID:21937707", "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002397 ; owl:annotatedTarget "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002397 ; owl:annotatedTarget "CD16+ monocyte" . [] oboInOwl:source "PMID:22753107" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035097 ; owl:annotatedTarget obo:UBERON_0035091 . [] oboInOwl:hasDbXref "PMID:22753107", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035097 ; owl:annotatedTarget "A muscle that attaches to the iliac crest and to a caudal vertebra." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035102 ; owl:annotatedTarget "A transverse process that is part of a caudal vertebra." . [] oboInOwl:hasDbXref "FMA:19646" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035104 ; owl:annotatedTarget "penile raphe" . [] oboInOwl:hasDbXref "FMA:19646", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035104 ; owl:annotatedTarget "raphe penis" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035105 ; owl:annotatedTarget "Any of the two testis-carrying compartments of the scrotum." . [] oboInOwl:hasDbXref "FMA:18251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035105 ; owl:annotatedTarget "scrotal sac" . (obo:UBERON_0034929 [ a owl:Restriction ; owl:onProperty obo:BSPO_0005001 ; owl:someValuesFrom obo:UBERON_0002356 ] [ a owl:Restriction ; owl:onProperty obo:RO_0000086 ; owl:someValuesFrom obo:PATO_0002358 ] ) . _:genid158597 oboInOwl:source "Wikipedia" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035106 ; owl:annotatedTarget _:genid160861 ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757 . [] oboInOwl:hasDbXref "Wikipedia:Perineal_raphe" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035106 ; owl:annotatedTarget "The perineal raphe extends from the anus, through the mid-line of the scrotum (scrotal raphe) and upwards through the posterior mid-line aspect of the penis (penile raphe)." . _:genid158599 oboInOwl:hasDbXref "FMA:20244" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035106 ; owl:annotatedTarget "perineal raphe" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0016612 . [] oboInOwl:hasDbXref "Wikipedia:Perineal_raphe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035106 ; owl:annotatedTarget "raphe perinealis" . [] oboInOwl:hasDbXref "Wikipedia:Perineal_raphe" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035106 ; owl:annotatedTarget "raphe perinei" . _:genid158606 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001757, obo:UBERON_0002103 . _:genid158608 oboInOwl:hasDbXref "Wikipedia:Plantar_nerve", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035109 ; owl:annotatedTarget "A nerve that innervates the sole of the foot. Planar nerves arise from the posterior branch of the tibial nerve." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0016612 . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0035110 ; owl:annotatedTarget obo:UBERON_0035111 . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plantar_nerve", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035110 ; owl:annotatedTarget "A plantar nerve that supplies the lateral side of the plantar part of the foot, including pedal digit 5." . [] oboInOwl:hasDbXref "FMA:44724" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035110 ; owl:annotatedTarget "external plantar nerve" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plantar_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035110 ; owl:annotatedTarget "nervus plantaris lateralis" . [] oboInOwl:hasDbXref "Wikipedia:Lateral_plantar_nerve", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035111 ; owl:annotatedTarget "A plantar nerve that supplies the medial side of the plantar part of the foot, including pedal digit 1." . [] oboInOwl:hasDbXref "FMA:44716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035111 ; owl:annotatedTarget "internal plantar nerve" . [] oboInOwl:hasDbXref "Wikipedia:Medial_plantar_nerve" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035111 ; owl:annotatedTarget "nervus plantaris medialis" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/intrinsic+muscles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035112 ; owl:annotatedTarget "Any of the muscles that are entirely within the body part or segment moved by them." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035115 ; owl:annotatedTarget "A space or gap between the left and right central incisors, on either the upper or lower jaw." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035116 ; owl:annotatedTarget "A space or gap between the left and right central incisors on the upper jaw." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035117 ; owl:annotatedTarget "A space or gap between the left and right central incisors on the lower jaw." . [] oboInOwl:hasDbXref "https://github.com/EnvironmentOntology/envo/issues/110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035118 ; owl:annotatedTarget "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035118 ; owl:annotatedTarget "digestive tract contents" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035119 ; owl:annotatedTarget "A space or gap any two incisors. This may be a midline diastema between central incisors, or a diastema located entirely in a single jaw quadrant between lateral incisors." . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/palatine%20suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035127 ; owl:annotatedTarget "Any of the sutures of the hard palate." . [] oboInOwl:hasDbXref "http://www.merriam-webster.com/medical/palatine%20suture" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035127 ; owl:annotatedTarget "palatine suture" . _:genid158663 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0015063 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002398 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0002418 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010913 . [] oboInOwl:source "EMAPA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035128 ; owl:annotatedTarget _:genid160934 . [] oboInOwl:hasDbXref "EMAPA:32631" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035128 ; owl:annotatedTarget "hand cartilage condensation" . [] oboInOwl:source "EMAPA-modified" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035129 ; owl:annotatedTarget _:genid160943 . [] oboInOwl:hasDbXref "EMAPA:32657" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035129 ; owl:annotatedTarget "foot cartilage condensation" . [] oboInOwl:source "MA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget _:genid160946 . [] oboInOwl:source "PMID:11523816" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget _:genid160948 . [] oboInOwl:source "PMID:11237469", "https://github.com/obophenotype/uberon/wiki/The-neural-crest" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget _:genid160950 . [] oboInOwl:hasDbXref "EMAPA:17824", "Wikipedia:Auditory_ossicle" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget "ossicle element" . [] oboInOwl:hasDbXref "MP:0005105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget "middle ear ossicle element" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget "ear ossicles element" . [] oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035130 ; owl:annotatedTarget "ossicular chain element" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20628149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002398 ; owl:annotatedTarget "An intermediate monocyte that is Gr1-positive, CD43-positive." . [] oboInOwl:hasDbXref "EMAPA:35979" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035131 ; owl:annotatedTarget "ossicle cartilage condensation" . [] oboInOwl:hasDbXref "EMAPA:35982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035132 ; owl:annotatedTarget "ossicle pre-cartilage condensation" . [] oboInOwl:hasDbXref "Wikipedia:Arches_of_the_foot#Longitudinal_arches" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035133 ; owl:annotatedTarget "A curved region of the skeleton of the pes (foot) formed by the tarsal and metatarsal bones." . [] oboInOwl:source "PMC2048995" ; a owl:Axiom ; owl:annotatedProperty obo:RO_0002175 ; owl:annotatedSource obo:UBERON_0035133 ; owl:annotatedTarget obo:NCBITaxon_9780 . [] oboInOwl:external_ontology "FMA" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000012 ; owl:annotatedSource obo:UBERON_0035133 ; owl:annotatedTarget "in FMA this is modeled as an anatomical line, here we model as an actual subdivision of the skeletal system, containing a row of bones as parts, arranged in a particular configuration" . [] oboInOwl:hasDbXref "FMA:75030" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035133 ; owl:annotatedTarget "longitudinal arch of foot" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/anterior+nasal+spine" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035139 ; owl:annotatedTarget "A pointed projection at the front extremity of the intermaxillary suture." . [] oboInOwl:hasDbXref "FMA:75770", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035139 ; owl:annotatedTarget "spina nasalis anterior corporis maxillae" . [] oboInOwl:hasDbXref "FMA:61695" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035159 ; owl:annotatedTarget "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface." . [] oboInOwl:hasDbXref "FMA:61695" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035159 ; owl:annotatedTarget "surface of body" . [] oboInOwl:source "lexical" ; a owl:Axiom ; owl:annotatedProperty owl:disjointWith ; owl:annotatedSource obo:UBERON_0035165 ; owl:annotatedTarget obo:UBERON_0035523 . [] oboInOwl:hasDbXref "ncithesaurus:Posterior_Surface_of_the_Prostate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035165 ; owl:annotatedTarget "The flattened aspect of the prostate with a slight furrow facing the rectum and anus." . [] oboInOwl:hasDbXref "FMA:19592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035165 ; owl:annotatedTarget "facies posterior (prostatae)" . [] oboInOwl:hasDbXref "FMA:19592", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035165 ; owl:annotatedTarget "facies posterior prostatae" . [] oboInOwl:hasDbXref "FMA:19592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035165 ; owl:annotatedTarget "posterior surface of prostate gland" . [] oboInOwl:hasDbXref "ncithesaurus:Right_Ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035174 ; owl:annotatedTarget "The organ of hearing located on the right side of the head." . [] oboInOwl:hasDbXref "ncithesaurus:Superficial_Lymphatic_Vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035198 ; owl:annotatedTarget "The tubules that carry lymph throughout the body that are just beneath the surface of the skin." . [] oboInOwl:hasDbXref "FMA:52011" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035198 ; owl:annotatedTarget "superficial lymph vessel" . [] oboInOwl:hasDbXref "FMA:70506" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035237 ; owl:annotatedTarget "internal carotid arterial subdivision" . [] oboInOwl:hasDbXref "FMA:70506" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035237 ; owl:annotatedTarget "subdivision of internal carotid artery" . [] oboInOwl:hasDbXref "ncithesaurus:Gallbladder_Neck" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035267 ; owl:annotatedTarget "The narrowest portion of the gallbladder and distal to the cystic duct." . [] oboInOwl:hasDbXref "FMA:14538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035267 ; owl:annotatedTarget "cervix of gallbladder" . [] oboInOwl:hasDbXref "FMA:14538" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035267 ; owl:annotatedTarget "gallbladder neck" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "ncithesaurus:Left_Ear" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035295 ; owl:annotatedTarget "The organ of hearing located on the left side of the head[ncit,modified]." . [] oboInOwl:hasDbXref "FMA:76259" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035307 ; owl:annotatedTarget "vertebral arterial branch" . [] oboInOwl:hasDbXref "FMA:55063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035313 ; owl:annotatedTarget "posterior wall of hypopharynx" . [] oboInOwl:hasDbXref "ncithesaurus:Capsule_of_the_Prostate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035316 ; owl:annotatedTarget "The membrane the surrounds the prostate gland." . [] oboInOwl:hasDbXref "FMA:19583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035316 ; owl:annotatedTarget "capsule of prostate" . [] oboInOwl:hasDbXref "FMA:19583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035316 ; owl:annotatedTarget "capsule of prostate gland" . [] oboInOwl:hasDbXref "FMA:14765" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035322 ; owl:annotatedTarget "trunk of right common iliac arterial tree" . [] oboInOwl:hasDbXref "FMA:50081" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035350 ; owl:annotatedTarget "middle cerebral arterial branch" . [] oboInOwl:hasDbXref "ncithesaurus:Retroperitoneal_Lymph_Node" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035371 ; owl:annotatedTarget "A lymph node located in the retroperitoneal space." . [] oboInOwl:hasDbXref "FMA:16694" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035371 ; owl:annotatedTarget "retroperitoneal node" . [] oboInOwl:hasDbXref "FMA:54908" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035383 ; owl:annotatedTarget "lateral nasopharynx" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Beilstein:3648446" . [] oboInOwl:hasDbXref "FMA:70505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035398 ; owl:annotatedTarget "external carotid arterial subdivision" . [] oboInOwl:hasDbXref "FMA:70505" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035398 ; owl:annotatedTarget "subdivision of external carotid artery" . [] oboInOwl:hasDbXref "FMA:54907" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035401 ; owl:annotatedTarget "posterior nasopharynx" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035403 ; owl:annotatedTarget "An artery that supplies the pituitary gland." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget _:genid161084 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget _:genid161086 . [] oboInOwl:hasDbXref "ncithesaurus:Mediastinal_Pleura" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget "The parietal pleura that lines the mediastinum." . [] oboInOwl:hasDbXref "FMA:9736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget "mediastinal part of parietal pleura" . [] oboInOwl:hasDbXref "FMA:9736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget "pars mediastinalis (pleurae)" . [] oboInOwl:hasDbXref "FMA:9736", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035431 ; owl:annotatedTarget "pars mediastinalis pleurae parietalis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002400 ; owl:annotatedTarget obo:CL_0000817 . [] oboInOwl:hasDbXref "ncithesaurus:Right_Suprarenal_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035435 ; owl:annotatedTarget "A vein that drains blood from the right adrenal gland into the inferior vena cava." . [] oboInOwl:hasDbXref "FMA:14343" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035435 ; owl:annotatedTarget "vena suprarenalis (adrenalis) dextra" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002400 ; owl:annotatedTarget "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." . [] oboInOwl:hasDbXref "FMA:15590" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035471 ; owl:annotatedTarget "facies posterior (Ren)" . [] oboInOwl:hasDbXref "FMA:15590", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035471 ; owl:annotatedTarget "facies posterior renis" . [] oboInOwl:hasDbXref "ncithesaurus:Surface_of_the_Prostate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035480 ; owl:annotatedTarget "The external portion of the prostate including the anterior, inferolateral, lateral and posterior surfaces." . [] oboInOwl:hasDbXref "FMA:19590" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035480 ; owl:annotatedTarget "prostatic surface" . [] oboInOwl:hasDbXref "FMA:19590" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035480 ; owl:annotatedTarget "surface of prostate gland" . [] oboInOwl:hasDbXref "ncithesaurus:Left_Suprarenal_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035483 ; owl:annotatedTarget "A vein that drains blood from the left adrenal gland into the left renal artery." . [] oboInOwl:hasDbXref "FMA:76269" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035489 ; owl:annotatedTarget "basilar arterial branch" . [] oboInOwl:hasDbXref "ncithesaurus:Anterior_Surface_of_the_Prostate" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035523 ; owl:annotatedTarget "The aspect of the prostate facing the pubic symphysis." . [] oboInOwl:hasDbXref "FMA:19591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035523 ; owl:annotatedTarget "anterior surface of prostate gland" . [] oboInOwl:hasDbXref "FMA:19591" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035523 ; owl:annotatedTarget "facies anterior (prostatae)" . [] oboInOwl:hasDbXref "FMA:19591", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035523 ; owl:annotatedTarget "facies anterior prostatae" . [] oboInOwl:hasDbXref "FMA:14766" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035529 ; owl:annotatedTarget "trunk of left common iliac arterial tree" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035539 ; owl:annotatedTarget obo:UBERON_0004573 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035539 ; owl:annotatedTarget _:genid161146 . [] oboInOwl:hasDbXref "ncithesaurus:Esophageal_Artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035539 ; owl:annotatedTarget "Any of several arteries that arise from the aorta and supply blood to the esophagus." . [] oboInOwl:hasDbXref "FMA:4149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035539 ; owl:annotatedTarget "aortic esophageal artery" . [] oboInOwl:hasDbXref "FMA:4149" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035539 ; owl:annotatedTarget "oesophageal artery" . [] oboInOwl:hasDbXref "ncithesaurus:Deep_Lymphatic_Vessel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035545 ; owl:annotatedTarget "The tubules that carry lymph throughout the body that are in the interior of the body or limbs." . [] oboInOwl:hasDbXref "FMA:52012" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035545 ; owl:annotatedTarget "deep lymph vessel" . [] oboInOwl:hasDbXref "FMA:51797" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035546 ; owl:annotatedTarget "ciliary vein" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035549 ; owl:annotatedTarget "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." . [] oboInOwl:hasDbXref "FMA:225275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035549 ; owl:annotatedTarget "vasculature of skin" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "CAS:14808-79-8" . [] oboInOwl:hasDbXref "ncithesaurus:Superficial_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035550 ; owl:annotatedTarget "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers." . [] oboInOwl:hasDbXref "Wikipedia:Superficial_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035550 ; owl:annotatedTarget "superfical vein" . _:genid158906 oboInOwl:hasDbXref "Wikipedia:Superficial_vein" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035550 ; owl:annotatedTarget "superficial veins" ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0006292 . [] oboInOwl:hasDbXref "Wikipedia:Superficial_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035550 ; owl:annotatedTarget "superficial vessels" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035551 ; owl:annotatedTarget "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin." . [] oboInOwl:hasDbXref "ncithesaurus:Deep_Vein" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035552 ; owl:annotatedTarget "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery." . [] oboInOwl:hasDbXref "Wikipedia:Deep_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035552 ; owl:annotatedTarget "deep veins" . [] oboInOwl:hasDbXref "Wikipedia:Deep_vein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035552 ; owl:annotatedTarget "deep vessels" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002405 ; owl:annotatedTarget obo:CL_0000893 . (obo:UBERON_0004151 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0000948 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035553 ; owl:annotatedTarget "Any chamber of the left side of the heart." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035554 ; owl:annotatedTarget "Any chamber of the right side of the heart." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20725107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002405 ; owl:annotatedTarget "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." . [] oboInOwl:hasDbXref "PMID:21452441", "XAO:0004093", "https://github.com/obophenotype/uberon/issues/693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035597 ; owl:annotatedTarget "An embryonic structure positioned halfway between the prospective eye and ear, adjacent to the future midbrain-hindbrain boundary. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." . [] oboInOwl:hasDbXref "NCBIBook:NBK53171" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035597 ; owl:annotatedTarget "ophthalmic lobe of trigeminal placode" . [] oboInOwl:hasDbXref "NCBIBook:NBK53171" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035597 ; owl:annotatedTarget "ophthalmic lobe of trigeminal placode complex" . [] oboInOwl:hasDbXref "PMID:22512454" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035597 ; owl:annotatedTarget "ophthalmic placode" . [] oboInOwl:hasDbXref "XAO:0004093" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035597 ; owl:annotatedTarget "profundus placode" . [] oboInOwl:hasDbXref "FMA:61298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035606 ; owl:annotatedTarget "cartilage of acoustic meatus" . [] oboInOwl:hasDbXref "FMA:61298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035606 ; owl:annotatedTarget "cartilage of auditory canal" . [] oboInOwl:hasDbXref "FMA:TA" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035606 ; owl:annotatedTarget "cartilago meatus acustici" . [] oboInOwl:hasDbXref "FMA:61298" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035606 ; owl:annotatedTarget "external acoustic meatus cartilage" . (obo:UBERON_0001473 [ a owl:Restriction ; owl:onProperty obo:RO_0001025 ; owl:someValuesFrom obo:UBERON_0002363 ] ) . [] oboInOwl:hasDbXref "DOI:10.1038/nature14432", "DOI:10.1111/joa.12381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035608 ; owl:annotatedTarget "Any lymph vessel that is located in the dura mater of the brain." . [] oboInOwl:hasDbXref "HPO:pr", "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/ocular+adnexa", "https://github.com/obophenotype/uberon/issues/1132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ocular+adnexa" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "adnexa oculi" . [] oboInOwl:hasDbXref "FMA:76554", "Wikipedia:Accessory_visual_structures" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "accessory visual structures" . [] oboInOwl:hasDbXref "FMA:76554" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "accessory visual structures set" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ocular+adnexa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "appendage of eye" . _:genid158958 oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ocular+adnexa" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "appendages of the eye" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005032 . [] oboInOwl:hasDbXref "FMA:76554" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "set of accessory visual structures" . [] oboInOwl:hasDbXref "Wikipedia:Accessory_visual_structures" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035639 ; owl:annotatedTarget "structurae oculi accessoriae" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035642 ; owl:annotatedTarget "Any nerve that innervates the larynx." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035648 ; owl:annotatedTarget _:genid161243 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035648 ; owl:annotatedTarget "Any nerve that innervates the pinna." . [] oboInOwl:hasDbXref "MA:0001232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035648 ; owl:annotatedTarget "auricular nerve" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035649 ; owl:annotatedTarget "Any nerve that innervates the penis." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035650 ; owl:annotatedTarget "Any nerve that innervates the clitoris." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035652 ; owl:annotatedTarget "Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches." . [] oboInOwl:hasDbXref "FMA:50919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035662 ; owl:annotatedTarget "anterior parotid vein" . [] oboInOwl:hasDbXref "FMA:50919" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035662 ; owl:annotatedTarget "parotid branch of facial vein" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "CAS:14808-79-8" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002419 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035763 ; owl:annotatedTarget _:genid161278 . [] oboInOwl:hasDbXref "FMA:9464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035763 ; owl:annotatedTarget "cardiac chamber cavity" . [] oboInOwl:hasDbXref "FMA:9464" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035763 ; owl:annotatedTarget "heart cavity" . [] oboInOwl:hasDbXref "EHDAA2:0004181" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035763 ; owl:annotatedTarget "heart lumen" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002419 ; owl:annotatedTarget "A T cell that expresses a T cell receptor complex and has completed T cell selection." . [] oboInOwl:hasDbXref "FMA:5968" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035764 ; owl:annotatedTarget "intrapulmonary lymph node" . [] oboInOwl:hasDbXref "FMA:5968" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035764 ; owl:annotatedTarget "pulmonary node" . [] oboInOwl:source "http://orcid.org/0000-0001-9114-8737" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035776 ; owl:annotatedTarget _:genid161293 . [] oboInOwl:hasDbXref "PMID:2802184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035776 ; owl:annotatedTarget "A parasympathetic ganglion located on the short ciliary nerve differentiated from the main ciliary ganglion by virtue of the fact that it had no root derived directly from the inferior trunk of the oculomotor nerve and it never attaches to this nerve." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035783 ; owl:annotatedTarget "Any parasympathetic ganglion that extends fibers into the short ciliary nerve. Includes both the main and acccessory ciliary ganglia." . [] oboInOwl:hasDbXref "PMID:18482984", "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035784 ; owl:annotatedTarget "A portion of semen in a coagulated state." . [] oboInOwl:hasDbXref "PMID:18482984" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035784 ; owl:annotatedTarget "seminal coagulum" . [] oboInOwl:hasDbXref "MP:0003119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035804 ; owl:annotatedTarget "The primordial mouth region of the developing head." . [] oboInOwl:hasDbXref "FMA:293105" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035804 ; owl:annotatedTarget "primitive mouth" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1162" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035805 ; owl:annotatedTarget "A muscle layer that is part of the sigmoid colon." . [] oboInOwl:hasDbXref "FMA:15028" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035805 ; owl:annotatedTarget "muscularis externa of sigmoid colon" . [] oboInOwl:hasDbXref "DOI:10.5935/abc.20130138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035814 ; owl:annotatedTarget "The sum of epicardial and paracardial fat deposits." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002420 ; owl:annotatedTarget obo:CL_0000084 . [] oboInOwl:hasDbXref "DOI:10.5935/abc.20130138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035815 ; owl:annotatedTarget "Fat deposits in the mediastinum outside the parietal pericardium ." . [] oboInOwl:hasDbXref "DOI:10.5935/abc.20130138" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035815 ; owl:annotatedTarget "intrathoracic fat" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035818 ; owl:annotatedTarget "Any fat deposit surrounding a visceral organ." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002420 ; owl:annotatedTarget "A T cell that has not completed T cell selection." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035819 ; owl:annotatedTarget "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035819 ; owl:annotatedTarget "cavitas abdominis et pelvis" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/86" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035820 ; owl:annotatedTarget "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." . [] oboInOwl:hasDbXref "EMAPA:16137" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035820 ; owl:annotatedTarget "peritoneal component" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035825 ; owl:annotatedTarget obo:UBERON_0001235 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035825 ; owl:annotatedTarget "The thick outer layer of the adrenal gland that is in the left side of the abdomen." . [] oboInOwl:hasDbXref "FMA:69089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035825 ; owl:annotatedTarget "cortex of left adrenal gland" . [] oboInOwl:hasDbXref "FMA:69089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035825 ; owl:annotatedTarget "cortex of left suprarenal gland" . [] oboInOwl:hasDbXref "FMA:69089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035825 ; owl:annotatedTarget "left adrenal cortex" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035826 ; owl:annotatedTarget obo:UBERON_0001236 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035826 ; owl:annotatedTarget "The adrenal gland medulla that is in the left side of the abdomen." . [] oboInOwl:hasDbXref "FMA:69092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035826 ; owl:annotatedTarget "left adrenal medulla" . [] oboInOwl:hasDbXref "FMA:69092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035826 ; owl:annotatedTarget "medulla of left adrenal gland" . [] oboInOwl:hasDbXref "FMA:69092" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035826 ; owl:annotatedTarget "medulla of left suprarenal gland" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Gmelin:2120" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035827 ; owl:annotatedTarget obo:UBERON_0001235 . _:genid159105 oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1170" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035827 ; owl:annotatedTarget "The thick outer layer of the adrenal gland that is in the right side of the abdomen." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008878 . [] oboInOwl:hasDbXref "FMA:69088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035827 ; owl:annotatedTarget "cortex of right adrenal gland" . [] oboInOwl:hasDbXref "FMA:69088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035827 ; owl:annotatedTarget "cortex of right suprarenal gland" . [] oboInOwl:hasDbXref "FMA:69088" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035827 ; owl:annotatedTarget "right adrenal cortex" . _:genid159109 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0000958 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001233 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0008878 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035828 ; owl:annotatedTarget obo:UBERON_0001236 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035828 ; owl:annotatedTarget "The adrenal gland medulla that is in the right side of the abdomen." . [] oboInOwl:hasDbXref "FMA:69091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035828 ; owl:annotatedTarget "medulla of right adrenal gland" . [] oboInOwl:hasDbXref "FMA:69091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035828 ; owl:annotatedTarget "medulla of right suprarenal gland" . [] oboInOwl:hasDbXref "FMA:69091" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035828 ; owl:annotatedTarget "right adrenal medulla" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002421 ; owl:annotatedTarget obo:CL_0000558 . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=52793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035849 ; owl:annotatedTarget "The mostly sharp edge of the orbital opening that is the peripheral border of the base of the pyramidal orbit." . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=52793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035849 ; owl:annotatedTarget "margin of orbit" . [] oboInOwl:hasDbXref "FMA:TA", "http://www.medilexicon.com/medicaldictionary.php?t=52793" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035849 ; owl:annotatedTarget "margo orbitalis" . [] oboInOwl:hasDbXref "http://www.medilexicon.com/medicaldictionary.php?t=52793" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035849 ; owl:annotatedTarget "orbital rim" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002421 ; owl:annotatedTarget "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/frontomaxillary+suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035879 ; owl:annotatedTarget "A suture between the frontal bone and the frontal process of the maxilla." . [] oboInOwl:hasDbXref "FMA:52950" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035879 ; owl:annotatedTarget "frontomaxillary suture of skull" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035879 ; owl:annotatedTarget "sutura frontomaxillaris" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/ethmoidomaxillary+suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035881 ; owl:annotatedTarget "A suture between the orbital surface of the body of the maxilla with the orbital plate of the ethmoid bone." . [] oboInOwl:hasDbXref "FMA:52954" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035881 ; owl:annotatedTarget "ethmoidomaxillary suture of skull" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035881 ; owl:annotatedTarget "sutura ethmoidomaxillaris" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/sphenomaxillary+suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035882 ; owl:annotatedTarget "An inconstant suture between the pterygoid process of the sphenoid bone and the body of the maxilla." . [] oboInOwl:hasDbXref "FMA:52957" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035882 ; owl:annotatedTarget "sphenomaxillary suture of skull" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035882 ; owl:annotatedTarget "sutura sphenomaxillaris" . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/lacrimomaxillary+suture" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035883 ; owl:annotatedTarget "A suture between the lacrimal bone and the maxilla." . [] oboInOwl:hasDbXref "FMA:52961" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035883 ; owl:annotatedTarget "lacrimomaxillary suture of skull" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035883 ; owl:annotatedTarget "sutura lacrimomaxillaris" . [] oboInOwl:hasDbXref "MGI:csmith", "PMID:21538817", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035884 ; owl:annotatedTarget "A suture between the maxilla and premaxilla." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035884 ; owl:annotatedTarget "maxillary-premaxillary incisive suture" . [] oboInOwl:hasDbXref "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035884 ; owl:annotatedTarget "incisive suture" . [] oboInOwl:hasDbXref "MGI:csmith" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035884 ; owl:annotatedTarget "premaxillary suture" . [] oboInOwl:hasDbXref "HBA:9370" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035927 ; owl:annotatedTarget "parietal lobe sulci" . [] oboInOwl:hasDbXref "HBA:9370" ; oboInOwl:hasSynonymType core:ABBREVIATION ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035927 ; owl:annotatedTarget "PLs" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0035956 ; owl:annotatedTarget _:genid161456 . [] oboInOwl:hasDbXref "GOC:DOS", "https://github.com/obophenotype/uberon/issues/1209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0035956 ; owl:annotatedTarget "The lumen of the epididymis." . [] oboInOwl:hasDbXref "FMA:18274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035956 ; owl:annotatedTarget "epididymis lumen" . [] oboInOwl:hasDbXref "FMA:18274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035956 ; owl:annotatedTarget "lumen of epididymis" . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_0035965 ; owl:annotatedTarget "EMAPA:37987" . [] oboInOwl:hasDbXref "FMA:67473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0035965 ; owl:annotatedTarget "blood vessel wall" . [] oboInOwl:hasDbXref "BTO:0004378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0035965 ; owl:annotatedTarget "vascular wall" . [] oboInOwl:exactly "2" ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget _:genid161469 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "The line that divided the gluteal regions of the body." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:11200094" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002422 ; owl:annotatedTarget obo:CL_0000558 . [] oboInOwl:hasDbXref "FMA:20234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "anal cleft" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "crena analis" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "crena ani" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "crena interglutealis" . [] oboInOwl:hasDbXref "FMA:20234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "intergluteal crease" . [] oboInOwl:hasDbXref "FMA:20234" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036013 ; owl:annotatedTarget "natal cleft" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0-12203-052-4", "ISBN:0721601464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002422 ; owl:annotatedTarget "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." . [] oboInOwl:hasDbXref "Wikipedia:Gluteal_sulcus", "https://github.com/obophenotype/uberon/issues/1216" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036014 ; owl:annotatedTarget "A horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg." . [] oboInOwl:hasDbXref "FMA:20233", "Wikipedia:Gluteal_sulcus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036014 ; owl:annotatedTarget "gluteal fold" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036014 ; owl:annotatedTarget "sulcus glutealis" . [] oboInOwl:hasDbXref "Wikipedia:Gluteal_sulcus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036014 ; owl:annotatedTarget "gluteal crease" . [] oboInOwl:hasDbXref "Wikipedia:Gluteal_sulcus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036014 ; owl:annotatedTarget "horizontal gluteal crease" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036072 ; owl:annotatedTarget _:genid161501 . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036073 ; owl:annotatedTarget _:genid161507 . [] oboInOwl:hasDbXref "EHDAA2:0004071" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036073 ; owl:annotatedTarget "respiratory primordium associated mesenchyme" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget _:genid161510 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget _:genid161512 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget _:genid161514 . [] oboInOwl:hasDbXref "PMID:42339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget "A vein that leaves the vestibule through an individual bone canal running parallel to the vestibular aqueduct up to the dura of the posterior side of the petrosa in the area of the endolymphatic sac. It then opens in the inferior petrosal sinus or the jugular bulb. The vein receives other branches from the bone, dura and sac." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget "vena aqueductus vestibuli" . [] oboInOwl:hasDbXref "FMA:52367" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036074 ; owl:annotatedTarget "vestibular aqueduct vein" . [] oboInOwl:hasDbXref "http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1", "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036146 ; owl:annotatedTarget "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." . [] oboInOwl:hasDbXref "UBERON:cjm", "https://github.com/obophenotype/uberon/issues/1266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036150 ; owl:annotatedTarget "An organ subunit in the skin that gives rise to cutaneous appendage." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002423 ; owl:annotatedTarget obo:CL_0000806 . [] oboInOwl:hasDbXref "PMID:20082456", "UBERON:cjm", "Wikipedia:Incisura_anterior_auris", "https://github.com/obophenotype/human-phenotype-ontology/issues/2274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "A surface structure that is the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by theantitragus, and along its lower lateral margins and inferior boundary by the connection between the first two." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/human-phenotype-ontology/issues/2274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "incisura" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "incisura intertragica" . [] oboInOwl:hasDbXref "FMA:61175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "intertragal incisure" . [] oboInOwl:hasDbXref "FMA:61175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "intertragic incisure" . [] oboInOwl:hasDbXref "FMA:61175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "intertragic notch" . [] oboInOwl:hasDbXref "Wikipedia:Incisura_anterior_auris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "anterior auricular groove" . [] oboInOwl:hasDbXref "Wikipedia:Incisura_anterior_auris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "auricular notch" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20595614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002423 ; owl:annotatedTarget "A DN2 thymocyte that is Kit-hi." . [] oboInOwl:hasDbXref "Wikipedia:Incisura_anterior_auris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "incisura anterior auris" . _:genid159271 oboInOwl:hasDbXref "Wikipedia:Incisura_anterior_auris" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "intertragic incisure" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000166 . [] oboInOwl:hasDbXref "Wikipedia:Incisura_anterior_auris" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036212 ; owl:annotatedTarget "sulcus auriculae anterior" . [] oboInOwl:hasDbXref "NCIT:C54188", "https://github.com/obophenotype/uberon/issues/1319", "https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036214 ; owl:annotatedTarget "An anatomical junction that is between the sigmoid colon and rectum." . [] oboInOwl:hasDbXref "NCIT:C54188" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036214 ; owl:annotatedTarget "rectosigmoid region" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/1324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036215 ; owl:annotatedTarget "Material anatomical entity that forms the outermost boundary of an anatomical structure." . [] oboInOwl:hasDbXref "PMID:10874572", "https://github.com/obophenotype/uberon/issues/1326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036217 ; owl:annotatedTarget "A bodily fluid that is located in the coelom." . [] oboInOwl:source "NIFSTD" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036224 ; owl:annotatedTarget _:genid161572 . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036224 ; owl:annotatedTarget "The corticobulbar and corticospinal tracts combined." . [] oboInOwl:hasDbXref "BIRNLEX:1464", "MP:0002878", "neuronames:1320" ; oboInOwl:hasSynonymType core:INCONSISTENT ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0036224 ; owl:annotatedTarget "pyramidal tract" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036225 ; owl:annotatedTarget "Any gland that is part os the respiratory system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:11452993" . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036242 ; owl:annotatedTarget "A notochord that has persisted beyond the embryonic stage." . [] oboInOwl:hasDbXref "http://www.bumc.bu.edu/sexualmedicine/physicianinformation/female-genital-anatomy/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036243 ; owl:annotatedTarget "Fluid that lines the vaginal walls that consists of multiple secretions that collect in the vagina from different glands." . [] oboInOwl:hasDbXref "FMA:20932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036244 ; owl:annotatedTarget "A transudate found in the serous sac." . [] oboInOwl:hasDbXref "FMA:20932" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_0036244 ; owl:annotatedTarget "serous fluid" . [] oboInOwl:hasDbXref "http://www.newworldencyclopedia.org/entry/Mammary_gland", "https://github.com/obophenotype/uberon/issues/1349", "https://orcid.org/0000-0003-3308-6245" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036245 ; owl:annotatedTarget "Parenchymal tissue that consists of the alveoli, grape-like clusters where milk is stored, and branching ducts, which are tubular canals carrying gladular secretions." . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/incudostapedial+joint", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036246 ; owl:annotatedTarget "The small synovial joint connecting the inclus and the stapes, located between the lenticular process on the long crus of the incus and the head of the stapes." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036246 ; owl:annotatedTarget "articulatio incudostapedialis" . [] oboInOwl:hasDbXref "FMA:60065" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036246 ; owl:annotatedTarget "incudostapedial articulation" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002424 ; owl:annotatedTarget obo:CL_0000806 . [] oboInOwl:hasDbXref "http://medical-dictionary.thefreedictionary.com/incudomallear+joint", "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036247 ; owl:annotatedTarget "The saddle-shaped synovial joint connecting the incus and the malleus." . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036247 ; owl:annotatedTarget "articulatio incudomallearis" . [] oboInOwl:hasDbXref "FMA:60064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036247 ; owl:annotatedTarget "incudomallear articulation" . [] oboInOwl:hasDbXref "FMA:60064" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036247 ; owl:annotatedTarget "incudomalleolar joint" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20595614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002424 ; owl:annotatedTarget "A DN2 thymocyte that is Kit-low." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036248 ; owl:annotatedTarget "Any synovial joint that connects auditory ossicles." . [] oboInOwl:hasDbXref "FMA:60063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036248 ; owl:annotatedTarget "auditory ossicles joint" . [] oboInOwl:hasDbXref "FMA:60063" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036248 ; owl:annotatedTarget "joint of auditory ossicles" . [] oboInOwl:hasDbXref "FMA:53133" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036253 ; owl:annotatedTarget "cranial orifice" . _:genid159351 oboInOwl:hasDbXref "FMA:53133" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036253 ; owl:annotatedTarget "skull orifice" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0002456 . [] oboInOwl:hasDbXref "NCIT:C61360" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036262 ; owl:annotatedTarget "Any of the eight ligaments pertaining to the uterus including the anterior, posterior, lateral, sacro-uterine and round ligaments." . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticotemporal_nerve" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit." . [] oboInOwl:hasDbXref "FMA:52972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "ramus zygomaticotemporalis (Nervus zygomaticus)" . [] oboInOwl:hasDbXref "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "ramus zygomaticotemporalis nervus zygomatici" . [] oboInOwl:hasDbXref "FMA:52972" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "zygomaticotemporal branch of zygomatic nerve" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticotemporal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "zygomaticotemporal" . [] oboInOwl:hasDbXref "Wikipedia:Zygomaticotemporal_nerve" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036264 ; owl:annotatedTarget "zygomaticotemporal branch" . ( ) . [] oboInOwl:hasDbXref "EMAPA:30807" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_0036269 ; owl:annotatedTarget "vasculature of penis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036285 ; owl:annotatedTarget obo:UBERON_0004784 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036285 ; owl:annotatedTarget _:genid161666 . [] oboInOwl:hasDbXref "FMA:9556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036285 ; owl:annotatedTarget "Wall of ventricle which is continuous with the wall of aorta." . [] oboInOwl:hasDbXref "FMA:9556" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036285 ; owl:annotatedTarget "left ventricular wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036286 ; owl:annotatedTarget obo:UBERON_0004784 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036286 ; owl:annotatedTarget _:genid161675 . [] oboInOwl:hasDbXref "FMA:9533" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036286 ; owl:annotatedTarget "Wall of ventricle which is continuous with the wall of pulmonary trunk." . [] oboInOwl:hasDbXref "FMA:9533" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036286 ; owl:annotatedTarget "right ventricular wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036288 ; owl:annotatedTarget _:genid161683 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:11581495" . [] oboInOwl:hasDbXref "FMA:9553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036289 ; owl:annotatedTarget "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle." . _:genid159409 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002500, obo:UBERON_0036289 . [] oboInOwl:hasDbXref "UBERON:cjm", "https://github.com/obophenotype/human-phenotype-ontology/issues/3336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036293 ; owl:annotatedTarget "A small fold of mucous membrane in the mouth, connecting either the tongue or the lip to the mouth mucosa." . [] oboInOwl:hasDbXref "HP:0000190" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036293 ; owl:annotatedTarget "oral frenula" . [] oboInOwl:hasDbXref "HP:0000190" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036293 ; owl:annotatedTarget "oral frenulum" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036294 ; owl:annotatedTarget "A mucosa that is part of a lip region [Automatically generated definition]." . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036294 ; owl:annotatedTarget "labial mucosa" . [] oboInOwl:source "NCIT" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036295 ; owl:annotatedTarget _:genid161711 . [] oboInOwl:hasDbXref "NCIT:C54419" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036295 ; owl:annotatedTarget "The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036301 ; owl:annotatedTarget obo:UBERON_0006876 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0036304 ; owl:annotatedTarget "An anatomical structure that is located along the line dividing two regions of an anatomical structure." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036328 ; owl:annotatedTarget obo:UBERON_0000415 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036328 ; owl:annotatedTarget _:genid161732 . _:genid159445 oboInOwl:hasDbXref "FMA:14179" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036328 ; owl:annotatedTarget "coronary arterial wall" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0003721 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002425 ; owl:annotatedTarget obo:CL_0000827 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036343 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036343 ; owl:annotatedTarget _:genid161740 . _:genid159452 oboInOwl:hasDbXref "FMA:14657" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036343 ; owl:annotatedTarget "gallbladder wall" ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0018405 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036351 ; owl:annotatedTarget obo:UBERON_0000415 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036351 ; owl:annotatedTarget _:genid161748 . [] oboInOwl:hasDbXref "FMA:15089" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036351 ; owl:annotatedTarget "brachiocephalic arterial wall" . [] oboInOwl:hasDbXref "GOC:dsd", "GOC:tfm", "PMID:16551251", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002425 ; owl:annotatedTarget "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036352 ; owl:annotatedTarget obo:UBERON_0000415 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036352 ; owl:annotatedTarget _:genid161756 . [] oboInOwl:hasDbXref "FMA:15090" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036352 ; owl:annotatedTarget "subclavian arterial wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036362 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036362 ; owl:annotatedTarget _:genid161766 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036362 ; owl:annotatedTarget _:genid161768 . [] oboInOwl:hasDbXref "FMA:15704" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036362 ; owl:annotatedTarget "anal canal wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036375 ; owl:annotatedTarget obo:UBERON_0009916 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036375 ; owl:annotatedTarget _:genid161776 . [] oboInOwl:hasDbXref "FMA:15889" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036375 ; owl:annotatedTarget "right ureteral wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036376 ; owl:annotatedTarget obo:UBERON_0009916 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036376 ; owl:annotatedTarget _:genid161784 . [] oboInOwl:hasDbXref "FMA:15890" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036376 ; owl:annotatedTarget "left ureteral wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036422 ; owl:annotatedTarget obo:UBERON_0000415 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036422 ; owl:annotatedTarget _:genid161792 . [] oboInOwl:hasDbXref "FMA:18211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036422 ; owl:annotatedTarget "pulmonary arterial wall" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:11798107" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036441 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036441 ; owl:annotatedTarget _:genid161800 . [] oboInOwl:hasDbXref "FMA:18303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036441 ; owl:annotatedTarget "uterine tube wall" . [] oboInOwl:hasDbXref "FMA:18303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036441 ; owl:annotatedTarget "wall of fallopian tube" . [] oboInOwl:hasDbXref "FMA:18303" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036441 ; owl:annotatedTarget "wall of oviduct" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002427 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036521 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036521 ; owl:annotatedTarget _:genid161810 . [] oboInOwl:hasDbXref "FMA:19779" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036521 ; owl:annotatedTarget "urethral wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036523 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036523 ; owl:annotatedTarget _:genid161818 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002427 ; owl:annotatedTarget "A double-positive, alpha-beta thymocyte that is small and not proliferating." . [] oboInOwl:hasDbXref "FMA:19971" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036523 ; owl:annotatedTarget "vaginal wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036553 ; owl:annotatedTarget obo:UBERON_0000042 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036553 ; owl:annotatedTarget _:genid161826 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036654 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036654 ; owl:annotatedTarget _:genid161833 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036655 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036655 ; owl:annotatedTarget _:genid161840 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036656 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036656 ; owl:annotatedTarget _:genid161847 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036657 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036657 ; owl:annotatedTarget _:genid161854 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036658 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036658 ; owl:annotatedTarget _:genid161861 . [] oboInOwl:hasDbXref "FMA:242780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036658 ; owl:annotatedTarget "wall of central canal" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036661 ; owl:annotatedTarget obo:UBERON_0005358 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036661 ; owl:annotatedTarget _:genid161869 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036925 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036925 ; owl:annotatedTarget _:genid161876 . [] oboInOwl:hasDbXref "FMA:58098" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036925 ; owl:annotatedTarget "eyeball wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036990 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0036990 ; owl:annotatedTarget _:genid161884 . [] oboInOwl:hasDbXref "FMA:60069" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0036990 ; owl:annotatedTarget "pharyngotympanic tube wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037089 ; owl:annotatedTarget obo:UBERON_0000075 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037089 ; owl:annotatedTarget _:genid161892 . [] oboInOwl:hasDbXref "FMA:63144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037089 ; owl:annotatedTarget "orbit wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037094 ; owl:annotatedTarget obo:UBERON_0000415 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037094 ; owl:annotatedTarget _:genid161900 . [] oboInOwl:hasDbXref "FMA:66284" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037094 ; owl:annotatedTarget "common carotid arterial wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget _:genid161908 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget _:genid161910 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget _:genid161912 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:12166931" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002428 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "FMA:7274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." . [] oboInOwl:hasDbXref "FMA:7274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037144 ; owl:annotatedTarget "cardiac wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037191 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037191 ; owl:annotatedTarget _:genid161921 . [] oboInOwl:hasDbXref "FMA:79837" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037191 ; owl:annotatedTarget "membranous labyrinth wall" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002428 ; owl:annotatedTarget "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037237 ; owl:annotatedTarget obo:UBERON_0000060 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037237 ; owl:annotatedTarget _:genid161929 . [] oboInOwl:hasDbXref "FMA:85375" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037237 ; owl:annotatedTarget "lacrimal ductal wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037447 ; owl:annotatedTarget obo:UBERON_0036521 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037447 ; owl:annotatedTarget _:genid161937 . [] oboInOwl:hasDbXref "FMA:19676" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037447 ; owl:annotatedTarget "male urethral wall" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037455 ; owl:annotatedTarget obo:UBERON_0036521 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0037455 ; owl:annotatedTarget _:genid161945 . [] oboInOwl:hasDbXref "FMA:19780" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037455 ; owl:annotatedTarget "female urethral wall" . [] oboInOwl:hasDbXref "FMA:54242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037458 ; owl:annotatedTarget "neck hair" . [] oboInOwl:hasDbXref "FMA:54243" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0037459 ; owl:annotatedTarget "limb hair" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039175 ; owl:annotatedTarget obo:UBERON_0000315 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039176 ; owl:annotatedTarget obo:UBERON_0000315 . [] oboInOwl:source "FMA", "Wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039222 ; owl:annotatedTarget _:genid161972 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165", "https://en.wikipedia.org/wiki/Cystic_artery" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0039222 ; owl:annotatedTarget "An artery that supplies oxygenated blood to the cystic duct." . [] oboInOwl:hasDbXref "FMA:14835" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0039222 ; owl:annotatedTarget "cholecystic artery" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039228 ; owl:annotatedTarget _:genid161980 . [] oboInOwl:hasDbXref "A12.2.15.042" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_0039355 ; owl:annotatedTarget "arteria urethralis" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039377 ; owl:annotatedTarget _:genid161996 . [] oboInOwl:hasDbXref "UBERON:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0039377 ; owl:annotatedTarget "A vein that drains the urethra." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039856 ; owl:annotatedTarget obo:UBERON_0001145 . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039856 ; owl:annotatedTarget _:genid162004 . [] oboInOwl:hasDbXref "FMA:14342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0039856 ; owl:annotatedTarget "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_0039857 ; owl:annotatedTarget obo:UBERON_0001145 . [] oboInOwl:hasDbXref "FMA:14347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_0039857 ; owl:annotatedTarget "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000004 ; owl:annotatedTarget "A collection of hairs that grows on the external ear." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:12668033" . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000006 ; owl:annotatedTarget "A collection of hairs that grows on the forehead." . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000009 ; owl:annotatedTarget "A ridge or peak located along the middle part of the head, located approximately equidistant from the left and the right sides of the head." . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000015 ; owl:annotatedTarget "A zone of skin that is part of the snout." . [] oboInOwl:source "MA:th" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_1000015 ; owl:annotatedTarget "EMAPA:37746" . [] oboInOwl:hasDbXref "MA:0003079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_1000015 ; owl:annotatedTarget "snout skin" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002429 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000020 ; owl:annotatedTarget "A collection of hairs that grows on the snout." . [] oboInOwl:hasDbXref "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000021 ; owl:annotatedTarget "A zone of skin that is part of the face." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002429 ; owl:annotatedTarget "A double-positive thymocyte that is CD69-positive and has begun positive selection." . [] oboInOwl:source "ncithesaurus:Skin_of_the_Face" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_1000021 ; owl:annotatedTarget "UMLS:C0222084" . [] oboInOwl:hasDbXref "EMAPA:36657", "FMA:24758" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_1000021 ; owl:annotatedTarget "face skin" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_1000023 ; owl:annotatedTarget _:genid162044 . [] oboInOwl:hasDbXref "ncithesaurus:Splenic_Pulp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000023 ; owl:annotatedTarget "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." . [] oboInOwl:source "ncithesaurus:Splenic_Pulp" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_1000023 ; owl:annotatedTarget "UMLS:C0229691" . [] oboInOwl:hasDbXref "FMA:15845" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_1000023 ; owl:annotatedTarget "Malpighian corpuscles" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1000024 ; owl:annotatedTarget "A parenchyma that is part of a spleen." . [] oboInOwl:hasDbXref "FMA:16029" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_1000024 ; owl:annotatedTarget "splenic parenchyma" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_1100000 ; owl:annotatedTarget "An anatomical junction between two parts of the digestive tract." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2000238 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:source "EHDAA2" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_2001053 ; owl:annotatedTarget _:genid162065 . [] oboInOwl:hasDbXref "TAO:0001053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_2001053 ; owl:annotatedTarget "PICA" . [] oboInOwl:hasDbXref "ZFA:0001053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_2001053 ; owl:annotatedTarget "primitive internal carotid artery" . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2001073 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001269 ; owl:annotatedTarget "Fin or limb undergoing the process of regeneration." . [] oboInOwl:hasDbXref "ZFA:0001269" ; oboInOwl:hasSynonymType core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:UBERON_2001269 ; owl:annotatedTarget "regenerating fins" . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001388 ; owl:annotatedTarget "An epithelial-mesenchymal boundary that is part of a regenerating fin/limb." . [] oboInOwl:hasDbXref "OBOL:automatic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001389 ; owl:annotatedTarget "An epithelium that is part of a regenerating fin/limb." . [] oboInOwl:hasDbXref "ZFA:0001389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_2001389 ; owl:annotatedTarget "epidermal cap" . [] oboInOwl:hasDbXref "ZFA:0001389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_2001389 ; owl:annotatedTarget "wound epidermis" . [] oboInOwl:hasDbXref "ZFA:0001389" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_2001389 ; owl:annotatedTarget "wound epithelium" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001457 ; owl:annotatedTarget "Cartilage which is part of the axial skeleton." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2001457 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001626 ; owl:annotatedTarget "Tooth that is attached to the premaxilla." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2001626 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001947 ; owl:annotatedTarget "Joint that articulates the hyomandibular cartilage or bone and otic region cartilage or sphenotic bone, and often pterotic bone and prootic bone. Hyomandibular-otic region joint is paired." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2001947 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2001950 ; owl:annotatedTarget "Joint that articulates the left and right premaxillary bones. Inter-premaxillary joint is unpaired." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2001950 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "TAO:wd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2002260 ; owl:annotatedTarget "Joint that articulates the premaxilla and maxilla. Premaxillary-maxillary joint is paired." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:14597181" . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2002260 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:source "FMA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget obo:UBERON_0001982 . [] oboInOwl:source "ZFA" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget obo:UBERON_0004638 . [] oboInOwl:hasDbXref "Wikipedia:Capillary#Types", "Wikipedia:Fenestra_(histology)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse." . [] oboInOwl:hasDbXref "ZFA:0005260" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget "fenestrated blood vessel endothelium" . [] oboInOwl:source "ncithesaurus:Fenestrated_Capillary" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget "UMLS:C1179615" . [] oboInOwl:hasDbXref "FMA:63196" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_2005260 ; owl:annotatedTarget "fenestrated capillary vessel" . [] oboInOwl:hasDbXref "ZFIN:ZDB-PUB-090217-11" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2005273 ; owl:annotatedTarget "A thin layer of smooth muscle immediately beneath the base of the villi which permits the intestinal mucosa to dynamically move and fold." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2005273 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "http:www.vivo.colostate.edu/hbooks/pathphys/digestion/basics/gi_microanatomy.html" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_2005273 ; owl:annotatedTarget "intestinal lamina muscularis mucosae" . [] oboInOwl:hasDbXref "ZFIN:curator" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_2007013 ; owl:annotatedTarget "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." . [] oboInOwl:source "http://purl.obolibrary.org/obo/tao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_2007013 ; owl:annotatedTarget "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3000961 ; owl:annotatedTarget "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3000961 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3000972 ; owl:annotatedTarget "Dermal, epidermal, glandular and pigment structures of the external head integument." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3000972 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3000977 ; owl:annotatedTarget "Dermal, epidermal, glandular and pigment structures of the body integument." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3000977 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3000981 ; owl:annotatedTarget "Dermal, epidermal, glandular and pigment structures of the limb integument." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3000981 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002430 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3000982 ; owl:annotatedTarget "Dermal, epidermal, glandular and pigment structures of the tail integument." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3000982 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "AAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_3010200 ; owl:annotatedTarget "Blood vessels in respiratory skin." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002430 ; owl:annotatedTarget "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." . [] oboInOwl:source "http://purl.obolibrary.org/obo/aao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_3010200 ; owl:annotatedTarget "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "XAO:0004039", "XAO:EJS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4000013 ; owl:annotatedTarget "Skeletal tissue that is mineralized." . [] oboInOwl:hasDbXref "VSAO:0000013" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_4000013 ; owl:annotatedTarget "mineralized tissue" . [] oboInOwl:hasDbXref "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4000020 ; owl:annotatedTarget "Extracellular matrix that is mineralized." . [] oboInOwl:source "http://purl.obolibrary.org/obo/vsao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_4000020 ; owl:annotatedTarget "This class was sourced from an external ontology (vertebrate_skeletal_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . _:genid159865 a owl:Restriction ; owl:onProperty obo:RO_0002202, obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0004863, obo:UBERON_0008883 . [] oboInOwl:hasDbXref "PSPUB:0000170" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4000115 ; owl:annotatedTarget "Bone tissue mineralized with hydroxyapatite." . [] oboInOwl:source "http://purl.obolibrary.org/obo/vsao.owl" ; a owl:Axiom ; owl:annotatedProperty obo:UBPROP_0000004 ; owl:annotatedSource obo:UBERON_4000115 ; owl:annotatedTarget "This class was sourced from an external ontology (vertebrate_skeletal_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" . [] oboInOwl:hasDbXref "PHENOSCAPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4100000 ; owl:annotatedTarget "Anatomical projection that is composed of bone or cartilage tissue." . [] oboInOwl:hasDbXref "PHENOSCAPE:NI" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4100117 ; owl:annotatedTarget "Rib located anterior to the sacral region." . [] oboInOwl:hasDbXref "FMA:23356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_4200172 ; owl:annotatedTarget "collum anatomicum (Humerus)" . [] oboInOwl:hasDbXref "FMA:23356", "FMA:TA" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_4200172 ; owl:annotatedTarget "collum anatomicum humeri" . [] oboInOwl:hasDbXref "FMA:23356" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_4200172 ; owl:annotatedTarget "anatomic neck of humerus" . [] oboInOwl:hasDbXref "PHENOSCAPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4200230 ; owl:annotatedTarget "An anatomical surface that is part of a bone." . [] oboInOwl:hasDbXref "PHENOSCAPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4300226 ; owl:annotatedTarget "Mesenchyme that is part of a forelimb bud." . [] oboInOwl:hasDbXref "PHENOSCAPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_4300227 ; owl:annotatedTarget "Mesenchyme that is part of a hindlimb bud." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:15093386" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "manual digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "manual digit 1 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "manual digit 1 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "manual digit 1 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5001463 ; owl:annotatedTarget "manual digit I plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "pedal digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "pedal digit ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "pedal digit digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5001466 ; owl:annotatedTarget "pedal digit ray" . (obo:UBERON_5002544 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002102 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "manual digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "manual digit ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "manual digit digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5002389 ; owl:annotatedTarget "manual digit ray" . _:genid159939 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002411, obo:UBERON_0012140 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "digit ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "digit digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5002544 ; owl:annotatedTarget "digit ray" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "manual digit 2" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "manual digit 2 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "manual digit 2 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "manual digit 2 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003622 ; owl:annotatedTarget "manual digit II plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "manual digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "manual digit 3 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002431 ; owl:annotatedTarget obo:CL_0000809 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "manual digit 3 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "manual digit 3 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003623 ; owl:annotatedTarget "manual digit III plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002431 ; owl:annotatedTarget "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "manual digit 4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "manual digit 4 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "manual digit 4 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "manual digit 4 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003624 ; owl:annotatedTarget "manual digit IV plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "A subdivision of the autopod consisting of manual digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "manual digit 5" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "manual digit 5 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "manual digit 5 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "manual digit 5 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003625 ; owl:annotatedTarget "manual digit V plus metapodial segment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:15984785" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "pedal digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "pedal digit 1 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "pedal digit 1 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "pedal digit 1 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003631 ; owl:annotatedTarget "pedal digit I plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "pedal digit 2" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "pedal digit 2 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "pedal digit 2 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "pedal digit 2 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003632 ; owl:annotatedTarget "pedal digit II plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "pedal digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "pedal digit 3 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "pedal digit 3 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "pedal digit 3 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003633 ; owl:annotatedTarget "pedal digit III plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "pedal digit 4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "pedal digit 4 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "pedal digit 4 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "pedal digit 4 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003634 ; owl:annotatedTarget "pedal digit IV plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "A subdivision of the autopod consisting of pedal digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "pedal digit 5" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002432 ; owl:annotatedTarget obo:CL_0000810 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "pedal digit 5 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "pedal digit 5 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "pedal digit 5 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5003635 ; owl:annotatedTarget "pedal digit V plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002432 ; owl:annotatedTarget "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "digit 1 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "digit 1 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "digit 1 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006048 ; owl:annotatedTarget "digit I plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "digit 2" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "digit 2 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "digit 2 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "digit 2 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006049 ; owl:annotatedTarget "digit II plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "digit 3 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "digit 3 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "digit 3 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006050 ; owl:annotatedTarget "digit III plus metapodial segment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16186560" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "digit 4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "digit 4 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "digit 4 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "digit 4 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006051 ; owl:annotatedTarget "digit IV plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "A subdivision of the autopod consisting of digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." . [] oboInOwl:source "https://github.com/obophenotype/uberon/issues/458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000232 ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "digit 5" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "digit 5 ( phalanges plus metapodial) plus soft tissue" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "digit 5 digitopodial subdivision" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "digit 5 ray" . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5006052 ; owl:annotatedTarget "digit V plus metapodial segment" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5101463 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 1 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5101463 ; owl:annotatedTarget "manual digit I digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5101463 ; owl:annotatedTarget "manual digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5101463 ; owl:annotatedTarget "manual digit 1 skeleton" . _:genid160136 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_0001896, obo:UBERON_5001466 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5101466 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5101466 ; owl:annotatedTarget "pedal digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5101466 ; owl:annotatedTarget "pedal digit skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5102389 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002433 ; owl:annotatedTarget obo:CL_0000810 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5102389 ; owl:annotatedTarget "manual digit" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5102389 ; owl:annotatedTarget "manual digit skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5102544 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5102544 ; owl:annotatedTarget "digit" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002433 ; owl:annotatedTarget "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5102544 ; owl:annotatedTarget "digit skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103622 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 2 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103622 ; owl:annotatedTarget "manual digit II digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103622 ; owl:annotatedTarget "manual digit 2" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103622 ; owl:annotatedTarget "manual digit 2 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103623 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 3 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103623 ; owl:annotatedTarget "manual digit III digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103623 ; owl:annotatedTarget "manual digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103623 ; owl:annotatedTarget "manual digit 3 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103624 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 4 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103624 ; owl:annotatedTarget "manual digit IV digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103624 ; owl:annotatedTarget "manual digit 4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103624 ; owl:annotatedTarget "manual digit 4 skeleton" . _:genid160191 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003625 ] ) ; owl:onProperty obo:RO_0002473 ; owl:someValuesFrom obo:UBERON_0001827 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103625 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 5 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103625 ; owl:annotatedTarget "manual digit V digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103625 ; owl:annotatedTarget "manual digit 5" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16345535" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103625 ; owl:annotatedTarget "manual digit 5 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103631 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 1 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103631 ; owl:annotatedTarget "pedal digit I digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103631 ; owl:annotatedTarget "pedal digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103631 ; owl:annotatedTarget "pedal digit 1 skeleton" . _:genid160211 a owl:Class ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001713 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0018408 ] ), (obo:UBERON_0010912 [ a owl:Restriction ; owl:onProperty obo:RO_0002576 ; owl:someValuesFrom obo:UBERON_5003632 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103632 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 2 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103632 ; owl:annotatedTarget "pedal digit II digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103632 ; owl:annotatedTarget "pedal digit 2" . _:genid160220 oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom, owl:Class ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103632 ; owl:annotatedTarget "pedal digit 2 skeleton" ; owl:intersectionOf (obo:UBERON_0001021 [ a owl:Restriction ; owl:onProperty obo:RO_0002134 ; owl:someValuesFrom obo:UBERON_0001711 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0018408 ] ) . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103633 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 3 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103633 ; owl:annotatedTarget "pedal digit III digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103633 ; owl:annotatedTarget "pedal digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103633 ; owl:annotatedTarget "pedal digit 3 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103634 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 4 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103634 ; owl:annotatedTarget "pedal digit IV digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103634 ; owl:annotatedTarget "pedal digit 4" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002434 ; owl:annotatedTarget obo:CL_0000811 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103634 ; owl:annotatedTarget "pedal digit 4 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5103635 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 5 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5103635 ; owl:annotatedTarget "pedal digit V digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103635 ; owl:annotatedTarget "pedal digit 5" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002434 ; owl:annotatedTarget "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5103635 ; owl:annotatedTarget "pedal digit 5 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5106048 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 1 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5106048 ; owl:annotatedTarget "digit I digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106048 ; owl:annotatedTarget "digit 1" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106048 ; owl:annotatedTarget "digit 1 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5106049 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 2 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5106049 ; owl:annotatedTarget "digit II digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106049 ; owl:annotatedTarget "digit 2" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106049 ; owl:annotatedTarget "digit 2 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5106050 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 3 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5106050 ; owl:annotatedTarget "digit III digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106050 ; owl:annotatedTarget "digit 3" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106050 ; owl:annotatedTarget "digit 3 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5106051 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 4 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5106051 ; owl:annotatedTarget "digit IV digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106051 ; owl:annotatedTarget "digit 4" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106051 ; owl:annotatedTarget "digit 4 skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_5106052 ; owl:annotatedTarget "A subdivision of the skeleton of the autopod consisting of the phalanges of digit 5 plus the associated metapodial element." . [] oboInOwl:hasDbXref "https://github.com/obophenotype/uberon/issues/458" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_5106052 ; owl:annotatedTarget "digit V digitopodial skeleton" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; oboInOwl:hasSynonymType core:COMPARATIVE_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106052 ; owl:annotatedTarget "digit 5" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16347366" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:UBERON_5106052 ; owl:annotatedTarget "digit 5 skeleton" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500046 ; owl:annotatedTarget "The proximal-most point of the head of a femur." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500047 ; owl:annotatedTarget "The proximal-most point of the head of a humerus." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500049 ; owl:annotatedTarget "The proximal-most point of the greater trochanter of a femur." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Tuberosity_of_the_tibia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500062 ; owl:annotatedTarget "The tibial tuberosity is on the anterior side of a tibia and is where a patella ligament attaches." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500065 ; owl:annotatedTarget "An articular prominence of a talus that engages with the tibia." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002435 ; owl:annotatedTarget obo:CL_0000811 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500073 ; owl:annotatedTarget "Nasal bone on the left side of an organism when in anatomical position." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500074 ; owl:annotatedTarget "Nasal bone on the right side of an organism when in anatomical position." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002435 ; owl:annotatedTarget "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500075 ; owl:annotatedTarget "Zygomatic arch on the left side of an organism when in anatomical position." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500076 ; owl:annotatedTarget "Zygomatic arch on the right side of an organism when in anatomical position." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Radial_styloid_process" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500078 ; owl:annotatedTarget "A condyle on the distal end and lateral side of a radius." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-2699-3066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500094 ; owl:annotatedTarget "A raised projection on the calcaneus." . [] oboInOwl:hasDbXref "https://doi.org/10.1111/let.12011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500102 ; owl:annotatedTarget "Part of the orbital plate formed by the jugal (part of the zygomatic), lacrimal (which is sometimes fused), sometimes nasal (typically in species with elongated rostra), and maxilla bones anterior to the orbit." . [] oboInOwl:hasDbXref "ISSN:0001-0196", "http://hdl.handle.net/2246/997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500103 ; owl:annotatedTarget "A hollow (fossa) in the preorbital region, typically lying on the maxillary bone, although sometimes can touch nasal bones (e.g., modern Equus)." . [] oboInOwl:hasDbXref "DOI:10.1097/SCS.0000000000002945", "PMID:27483100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_7500107 ; owl:annotatedTarget "A suture joining a sphenoid bone with the alae of a vomer to form a schindylesis type of joint." . [] oboInOwl:hasDbXref "https://microbiomedb.org/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8000006 ; owl:annotatedTarget "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." . [] oboInOwl:hasDbXref "https://microbiomedb.org/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8000007 ; owl:annotatedTarget "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." . [] oboInOwl:hasDbXref "http://www.ncbi.nlm.nih.gov/books/NBK551565/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8300000 ; owl:annotatedTarget "A zone of skin that is part of a scalp." . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8300001 ; owl:annotatedTarget "A forelimb that is on the right side of a pectoral complex." . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8300002 ; owl:annotatedTarget "A forelimb that is on the left side of a pectoral complex." . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8300003 ; owl:annotatedTarget "A hindlimb that is on the right side of a pelvic complex." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16348007" . ( ) . [] oboInOwl:hasDbXref "UBERONREF:0000003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8300004 ; owl:annotatedTarget "A hindlimb that is on the left side of a pelvic complex." . [] oboInOwl:hasDbXref "https://medical-dictionary.thefreedictionary.com/serosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8400021 ; owl:annotatedTarget "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." . [] oboInOwl:hasDbXref "FMA:15811" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400021 ; owl:annotatedTarget "serosa of liver" . [] oboInOwl:SynonymTypeProperty "LATIN" ; oboInOwl:hasDbXref "https://medical-dictionary.thefreedictionary.com/serosa+of+liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400021 ; owl:annotatedTarget "tunica serosa hepatis" . [] oboInOwl:hasDbXref "FMA:15812", "https://medical-dictionary.thefreedictionary.com/subserosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8400023 ; owl:annotatedTarget "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." . [] oboInOwl:hasDbXref "FMA:15821" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400023 ; owl:annotatedTarget "tela subserosa (hepar)" . [] oboInOwl:hasDbXref "https://medical-dictionary.thefreedictionary.com/subserosa+of+liver" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400023 ; owl:annotatedTarget "tela subserosa hepatis" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002436 ; owl:annotatedTarget obo:CL_0000624 . [] oboInOwl:hasDbXref "PMID:30992875", "https://orcid.org/0000-0002-0449-2730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8400024 ; owl:annotatedTarget "Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses." . [] oboInOwl:hasDbXref "PMID:30992875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400024 ; owl:annotatedTarget "liver subcapsular region" . [] oboInOwl:hasDbXref "PMID:30992875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400024 ; owl:annotatedTarget "liver subcapsular tissue" . [] oboInOwl:hasDbXref "PMID:30992875" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8400024 ; owl:annotatedTarget "subcapsular tissue of liver" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002436 ; owl:annotatedTarget "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." . [] oboInOwl:hasDbXref "PMID:23961897", "PMID:29064554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410000 ; owl:annotatedTarget "The anatomical junction between the duodenum and the jejunum." . [] oboInOwl:hasDbXref "Wikipedia:Duodenojejunal_flexure" ; oboInOwl:hasSynonymType core:LATIN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8410000 ; owl:annotatedTarget "flexura duodenojejunalis" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410001 ; owl:annotatedTarget "Venule of villus of small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410002 ; owl:annotatedTarget "A lymphatic vessel that supplies the small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410004 ; owl:annotatedTarget "Arteriole of villus of small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410008 ; owl:annotatedTarget "A venule that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410009 ; owl:annotatedTarget "An arteriole that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410015 ; owl:annotatedTarget "An arteriole located in the colon." . [] oboInOwl:hasDbXref "PMID:27233374", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410016 ; owl:annotatedTarget "The anatomical junction between the descending colon and the sigmoid colon." . [] oboInOwl:hasDbXref "WikipediaVersioned:Left_colic_vein&oldid=964575339", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410017 ; owl:annotatedTarget "A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery." . [] oboInOwl:hasDbXref "DOI:10.1016/B978-1-4377-2206-2.00068-3", "PMID:21802415", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410019 ; owl:annotatedTarget "The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum." . _:genid160493 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160, obo:UBERON_0003692 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410024 ; owl:annotatedTarget "An anatomical junction between two parts of the intestine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16483812" . [] oboInOwl:hasDbXref "PMID:32491649", "WikipediaVersioned:Lymph_node&oldid=1020495758", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410032 ; owl:annotatedTarget "The trabecular sinus is the lymph-filled space outside the trabeculae between lobules of the lymph node. This is a continuation of the subcapsular sinus which receives the afferent vessels and is present beneath the capsule. This space is traversed by both reticular fibers and cells in the lymph." . [] oboInOwl:hasDbXref "PMID:17067937", "WikipediaVersioned:Lymph_node&oldid=1001655735#Structure", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410033 ; owl:annotatedTarget "A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002437 ; owl:annotatedTarget obo:CL_0000625 . [] oboInOwl:hasDbXref "PMID:17067937", "WikipediaVersioned:Lymph_node&oldid=1001655735#Structure", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410034 ; owl:annotatedTarget "An artery that enters the lymph node at the hilum and branches into smaller arterioles." . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002437 ; owl:annotatedTarget "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." . [] oboInOwl:hasDbXref "PMID:17067937", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410035 ; owl:annotatedTarget "An arteriole that arises from the hilar artery of a lymph node and radiates centrifugally, branching in the medulla." . [] oboInOwl:hasDbXref "PMID:17067937", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410036 ; owl:annotatedTarget "Medullary venules are a continuation of high endothelial venules which condense repeatedly in the interfollicular cortex and peripheral deep cortical unit and then transition to medullary venules at the corticomedullary junction. The medullary venules condense and return centripetally to the hilar vein." . [] oboInOwl:hasDbXref "PMID:17067937", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410041 ; owl:annotatedTarget "A venule that is part of a lymph node." . [] oboInOwl:hasDbXref "PMID:17067937", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410042 ; owl:annotatedTarget "An arteriole that is part of a lymph node." . _:genid160538 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000033, obo:UBERON_0002185 . _:genid160540 oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410043 ; owl:annotatedTarget "A submucosal gland located in a bronchus." ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0000924 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410048 ; owl:annotatedTarget "A venule located in the colon." . (obo:UBERON_0004921 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0000159 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001052 ] [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0001245 ] ) . ( ) . [] oboInOwl:hasDbXref "DOI:10.1007/978-3-319-26938-2_8", "DOI:10.1148/rg.2015150037", "PMID:29742860", "http://orcid.org/0000-0002-6826-8770", "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410050 ; owl:annotatedTarget "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410051 ; owl:annotatedTarget "A lymphatic vessel located in the colon." . _:genid160565 oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410056 ; owl:annotatedTarget "A capillary that is part of the anorectum." ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002244 . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410057 ; owl:annotatedTarget "A capillary that is part of the colon." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410068 ; owl:annotatedTarget "A capillary that is part of a small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410077 ; owl:annotatedTarget "A submucosal gland found in a respiratory tract." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-7655-4833", "https://en.wikipedia.org/wiki/Iliac_crest" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410079 ; owl:annotatedTarget "Red bone marrow located in an iliac crest." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:10704434", "PMID:11756508", "PMID:20142420", "PMID:2182078", "PMID:24133281", "PMID:9826671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410080 ; owl:annotatedTarget "Red bone marrow located in the sternum." . [] oboInOwl:hasDbXref "Wikipedia:Microcirculation", "http://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8410081 ; owl:annotatedTarget "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." . [] oboInOwl:hasDbXref "PMID:3126903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8420000 ; owl:annotatedTarget "Hair that grows on the scalp." . [] oboInOwl:hasDbXref "PMID:30783333" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:UBERON_8420000 ; owl:annotatedTarget "hair" . [] oboInOwl:hasDbXref "ISBN-10:0-87893-742-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8440004 ; owl:annotatedTarget "One or a subset of adjacent layers of the neocortex." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16534979" . [] oboInOwl:hasDbXref "PMID:24133281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "O-2A/OPC" . [] oboInOwl:hasDbXref "WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8440015 ; owl:annotatedTarget "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." . [] oboInOwl:hasDbXref "GO:0007588" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8450002 ; owl:annotatedTarget "An anatomical system that eliminates waste products that arise as a result of metabolic activity." . [] oboInOwl:hasDbXref "PMID:11756508" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "O2A/OPC" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0001-6595-0902", "https://www.ncbi.nlm.nih.gov/books/NBK53254/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8470000 ; owl:annotatedTarget "Blood located in the placenta." . [] oboInOwl:hasDbXref "NCIT:C77655", "PMID:32655159", "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8470001 ; owl:annotatedTarget "A lymph node with a lymph center located within the caudal abdomen and pelvis, on the ventral side of the lumbar region. Includes the medial iliac, internal iliac (previously termed hypogastric) and sacral lymph nodes." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480000 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an iliac vein." . [] oboInOwl:hasDbXref "PMID:2253328" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480001 ; owl:annotatedTarget "A capillary that is part of the brain." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480002 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of the thoracic aorta." . [] dcterms:contributor ; oboInOwl:hasDbXref "PMID:24133281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "oligodendrocyte/type-2 astrocyte progenitor cell" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480003 ; owl:annotatedTarget "A portion of smooth muscle tissue that is part of an iliac artery." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480004 ; owl:annotatedTarget "An endothelium that is part of an iliac vein." . [] oboInOwl:hasDbXref "ISBN:9780702028991", "PMID:10704434", "PMID:2182078" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_0002453 ; owl:annotatedTarget "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480005 ; owl:annotatedTarget "An endothelium that is part of the placental artery." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480006 ; owl:annotatedTarget "Lymphatic vessel that is part of the mesentery." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480007 ; owl:annotatedTarget "An artery that is part of the placenta." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480008 ; owl:annotatedTarget "A vein that is part of the placenta." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480014 ; owl:annotatedTarget "A zone of skin that is part of the buttock." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480024 ; owl:annotatedTarget "A zone of skin that is part of the sacral region." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480025 ; owl:annotatedTarget "A zone of skin that is above the clavicle zone in the pectoral girdle region." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480026 ; owl:annotatedTarget "A zone of skin that is above the iliac crest in the pelvic girdle bone/zone." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480029 ; owl:annotatedTarget "A zone of skin that is part of the external genitalia." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480030 ; owl:annotatedTarget "A zone of skin that is part of the breast." . ( ) . [] oboInOwl:hasDbXref "ISBN:9783662026762", "PMID:30095490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8480037 ; owl:annotatedTarget "Subserosa that is part of the uterine tube. It contains loose connective tissue, blood vessels and lymphatic tissue." . [] oboInOwl:hasDbXref "PMID:30095490" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8480037 ; owl:annotatedTarget "subserosa of fallopian tube" . [] oboInOwl:hasDbXref "PMID:34440264" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8480037 ; owl:annotatedTarget "subserosa of oviduct" . [] oboInOwl:hasDbXref "FMA:55697" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490001 ; owl:annotatedTarget "right upper second secondary molar tooth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16656509" . [] oboInOwl:hasDbXref "FMA:55698" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490002 ; owl:annotatedTarget "right upper first secondary molar tooth" . _:genid160709 oboInOwl:hasDbXref "FMA:55798" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490005 ; owl:annotatedTarget "right upper secondary canine tooth" ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005876 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002454 ; owl:annotatedTarget obo:CL_0002465 . [] oboInOwl:hasDbXref "FMA:55680" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490006 ; owl:annotatedTarget "right upper lateral secondary incisor tooth" . _:genid160715 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:UBERON_0016454 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001709 ] ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006261 . [] oboInOwl:hasDbXref "FMA:55681" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490007 ; owl:annotatedTarget "right upper central secondary incisor tooth" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002454 ; owl:annotatedTarget "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." . _:genid160722 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:BSPO_0000121 ; owl:someValuesFrom obo:UBERON_0001710, obo:UBERON_0006233 . [] oboInOwl:hasDbXref "FMA:55706" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490009 ; owl:annotatedTarget "right lower second secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55705" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490010 ; owl:annotatedTarget "right lower first secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55686" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490013 ; owl:annotatedTarget "right lower secondary canine tooth" . [] oboInOwl:hasDbXref "FMA:57140" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490014 ; owl:annotatedTarget "right lower lateral secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:57142" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490015 ; owl:annotatedTarget "right lower central secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84240" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490016 ; owl:annotatedTarget "right upper second primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84238" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490017 ; owl:annotatedTarget "right upper first primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84230" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490018 ; owl:annotatedTarget "right upper primary canine tooth" . [] oboInOwl:hasDbXref "FMA:84222" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490019 ; owl:annotatedTarget "right upper lateral primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84220" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490020 ; owl:annotatedTarget "right upper central primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84244" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490021 ; owl:annotatedTarget "right lower second primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84242" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490022 ; owl:annotatedTarget "right lower first primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84232" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490023 ; owl:annotatedTarget "right lower primary canine tooth" . [] oboInOwl:hasDbXref "FMA:84226" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490024 ; owl:annotatedTarget "right lower lateral primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84224" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490025 ; owl:annotatedTarget "right lower central primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55700" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490027 ; owl:annotatedTarget "left upper second secondary molar tooth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16742508" . [] oboInOwl:hasDbXref "FMA:55699" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490028 ; owl:annotatedTarget "left upper first secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55799" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490031 ; owl:annotatedTarget "left upper secondary canine tooth" . [] oboInOwl:hasDbXref "FMA:55683" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490032 ; owl:annotatedTarget "left upper lateral secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55682" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490033 ; owl:annotatedTarget "left upper central secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:55703" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490035 ; owl:annotatedTarget "left lower second secondary molar tooth" . [] oboInOwl:hasDbXref "FMA:55704" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490036 ; owl:annotatedTarget "left lower first secondary molar tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002457 ; owl:annotatedTarget obo:CL_0000453 . [] oboInOwl:hasDbXref "FMA:55687" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490039 ; owl:annotatedTarget "left lower secondary canine tooth" . [] oboInOwl:hasDbXref "FMA:57141" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490040 ; owl:annotatedTarget "left lower lateral secondary incisor tooth" . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002457 ; owl:annotatedTarget "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." . [] oboInOwl:hasDbXref "FMA:57143" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490041 ; owl:annotatedTarget "left lower central secondary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84241" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490042 ; owl:annotatedTarget "left upper second primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84239" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490043 ; owl:annotatedTarget "left upper first primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84231" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490044 ; owl:annotatedTarget "left upper primary canine tooth" . (obo:UBERON_0018594 [ a owl:Restriction ; owl:onProperty obo:BSPO_0000120 ; owl:someValuesFrom obo:UBERON_0001709 ] ) . [] oboInOwl:hasDbXref "FMA:84223" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490045 ; owl:annotatedTarget "left upper lateral primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84221" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490046 ; owl:annotatedTarget "left upper central primary incisor tooth" . [] oboInOwl:hasDbXref "FMA:84245" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490047 ; owl:annotatedTarget "left lower second primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84243" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490048 ; owl:annotatedTarget "left lower first primary molar tooth" . [] oboInOwl:hasDbXref "FMA:84233" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490049 ; owl:annotatedTarget "left lower primary canine tooth" . [] oboInOwl:hasDbXref "FMA:84227" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490050 ; owl:annotatedTarget "left lower lateral primary incisor tooth" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002460 ; owl:annotatedTarget obo:CL_0000941 . [] oboInOwl:hasDbXref "FMA:84225" ; oboInOwl:hasSynonymType core:HUMAN_PREFERRED ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8490051 ; owl:annotatedTarget "left lower central primary incisor tooth" . [] oboInOwl:hasDbXref "BTO:0002780", "CLAO:0001295" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8600004 ; owl:annotatedTarget "A muscle tissue that is associated with soft internal organs (viscera)." . [] a owl:Axiom ; rdfs:comment "BTO:0002780" ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:UBERON_8600004 ; owl:annotatedTarget "visceral muscle" . [] oboInOwl:hasDbXref "FBbt:00005070", "https://en.wikipedia.org/wiki/Smooth_muscle" ; a owl:Axiom ; rdfs:comment "PMID:8720463" ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:UBERON_8600004 ; owl:annotatedTarget "It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated." . [] oboInOwl:hasDbXref "PMID:8720463", "https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8600006 ; owl:annotatedTarget "A striated muscle tissue that is associated with soft internal organs (viscera)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:16742518" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002460 ; owl:annotatedTarget "A conventional thymic dendritic cell that is CD8alpha-negative." . [] oboInOwl:hasDbXref "PMID:17394068", "PMID:17707699", "PMID:25648514", "PMID:30864819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:UBERON_8600012 ; owl:annotatedTarget "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium." . [] a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001405 ] ) ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Class ; owl:complementOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] ] ) . [] a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001408 ] ) ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005929 ] ) . [] a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onClass obo:GO_0005634 ; owl:onProperty obo:RO_0002180 ; owl:qualifiedCardinality "2"^^xsd:nonNegativeInteger ] ) ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001406 ] ) . [] a owl:Class ; owl:equivalentClass _:genid160934 ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407 ] ) . _:genid160934 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onClass obo:GO_0005634 ; owl:onProperty obo:RO_0002180 ; owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ] ) ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0009523 . [] a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:intersectionOf _:genid160943 ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) . (obo:CL_0000000 [ a owl:Restriction ; owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ; owl:onClass obo:GO_0005634 ; owl:onProperty obo:RO_0002180 ] ) . _:genid160946 a owl:Class, owl:Restriction ; rdfs:subClassOf _:genid160950 ; owl:intersectionOf (obo:CL_0000000 _:genid160948 ) ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001756 . _:genid160948 a owl:Restriction ; owl:onProperty obo:BFO_0000050, obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001407, obo:UBERON_0008895 . _:genid160950 a owl:Restriction ; owl:onProperty obo:BFO_0000051, obo:RO_0002202 ; owl:someValuesFrom obo:GO_0005634, obo:UBERON_0003099 . [] a owl:Class ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:GO_0005634 ] ; owl:intersectionOf (obo:CL_0000000 [ a owl:Restriction ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0001908 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000160 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000945 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_0000164 ; owl:intersectionOf (obo:CL_0000163 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001264 ] ) . [] a owl:Class ; rdfs:subClassOf obo:CL_4033018 ; owl:intersectionOf (obo:CL_0000556 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000114 ] ) . [] a owl:Class ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] ; owl:intersectionOf (obo:UBERON_0001062 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0019233 ] ) . [] a owl:Class ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003942 ] ; owl:intersectionOf (obo:UBERON_0001062 [ a owl:Restriction ; owl:onProperty obo:RO_0002216 ; owl:someValuesFrom obo:GO_0050975 ] ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002462 ; owl:annotatedTarget obo:CL_0000990 . [] a owl:Restriction ; rdfs:subClassOf obo:CL_0000000 ; owl:onProperty obo:RO_0000053 ; owl:someValuesFrom obo:PATO_0010006 . [] a owl:Restriction ; rdfs:subClassOf [ a owl:Class ; owl:unionOf ([ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0002418 ; owl:someValuesFrom obo:BFO_0000015 ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002215 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0000056 ; owl:someValuesFrom [ a owl:Restriction ; owl:onProperty obo:RO_0002418 ; owl:someValuesFrom obo:BFO_0000015 ] ] ] ) ] ; owl:onProperty obo:RO_0002566 ; owl:someValuesFrom obo:BFO_0000040 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002462 ; owl:annotatedTarget "A F4/80-negative dendritic cell located in adipose tissue." . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002180 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000015 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000015 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002018 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:17120760" . [] a swrl:Imp ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000016 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000053 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000091 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000019 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000053 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000086 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000023 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000053 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000087 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:BFO_0000034 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000053 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0000085 ] ) . [] swrla:isRuleEnabled true ; a swrl:Imp ; rdfs:comment "MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z" ; rdfs:label "infer input from direct reg" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0003674 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0003674 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002463 ; owl:annotatedTarget "An adipose dendritic cell that is SIRPa-positive." . [] a swrl:Imp ; rdfs:comment """GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'""" ; rdfs:label "enabling an MF enables its parts" ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0003674 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000051 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] ) . [] swrla:isRuleEnabled true ; a swrl:Imp ; rdfs:comment "GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'" ; rdfs:label "involved in BP" ; swrl:body ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0008150 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:BFO_0000050 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002327 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002331 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate obo:GO_0016301 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002447 ] ) . [] a swrl:Imp ; rdfs:comment "If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this." ; rdfs:label "inferring direct reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002013 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] ) . [] a swrl:Imp ; rdfs:label "inferring direct neg reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] _:genid161084 ) ; swrl:head (_:genid161086 ) . _:genid161084 a owl:Restriction, swrl:IndividualPropertyAtom ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002400 ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002014 . _:genid161086 a owl:Restriction, swrl:IndividualPropertyAtom ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom obo:UBERON_0003728 ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 . [] a swrl:Imp ; rdfs:label "inferring direct positive reg edge from input to regulatory subfunction" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002352 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002333 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002015 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] ) . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002464 ; owl:annotatedTarget "An adipose dendritic cell that is SIRPa-negative." . [] a swrl:Imp ; rdfs:label "effector input is compound function input" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:17420092" . [] a swrl:Imp ; rdfs:label "Input of effector is input of its parent MF" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002233 ] ) . [] a swrl:Imp ; rdfs:comment "if effector directly regulates X, its parent MF directly regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002578 ] ) . [] a swrl:Imp ; rdfs:comment "if effector directly positively regulates X, its parent MF directly positively regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002629 ] ) . [] a swrl:Imp ; rdfs:label "if effector directly negatively regulates X, its parent MF directly negatively regulates X" ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002025 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002630 ] ) . [] a swrl:Imp ; rdfs:label "'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties)." ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002404 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002131 ] ) ; swrl:head ([ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] ) . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002465 ; owl:annotatedTarget obo:CL_0000990 . [] a swrl:Imp ; rdfs:label "'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties)." ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002411 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002131 ] ) ; swrl:head (_:genid161146 [ a swrl:ClassAtom ; swrl:argument1 ; swrl:classPredicate owl:Nothing ] ) . _:genid161146 a owl:Restriction, swrl:ClassAtom ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001515 ; swrl:argument1 ; swrl:classPredicate owl:Nothing . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0012011 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002211 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0012012 ] ) . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002465 ; owl:annotatedTarget "A conventional dendritic cell that expresses CD11b (ITGAM)." . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002213 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002213 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0019002 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002212 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0019001 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002264 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002411 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002263 ] ) . [] a swrl:Imp ; swrl:body ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002411 ] [ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0002411 ] ) ; swrl:head ([ a swrl:IndividualPropertyAtom ; swrl:argument1 ; swrl:argument2 ; swrl:propertyPredicate obo:RO_0012011 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002467 ; owl:annotatedTarget obo:CL_0000889 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002467 ; owl:annotatedTarget "A myeloid suppressor cell that is Gr1-high and CD11c-negative." . _:genid161243 a owl:Restriction ; owl:onProperty obo:RO_0002380 ; owl:someValuesFrom obo:UBERON_0001647 . _:genid161278 a owl:Restriction ; owl:onProperty obo:RO_0002219 ; owl:someValuesFrom obo:UBERON_0002165 . _:genid161293 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0035639 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:17709180" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002468 ; owl:annotatedTarget obo:CL_0000889 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002468 ; owl:annotatedTarget "A myeloid suppressor cell that is Gr1-low and CD11c-positive." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002469 ; owl:annotatedTarget obo:CL_0002395 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002469 ; owl:annotatedTarget "Gr1-high monocyte that lacks MHC-II receptor complex." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:18398178" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002470 ; owl:annotatedTarget obo:CL_0002395 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002470 ; owl:annotatedTarget "Gr1-high monocyte that has a MHC-II receptor complex." . _:genid161456 a owl:Restriction ; owl:onProperty obo:RO_0001019 ; owl:someValuesFrom obo:UBERON_0006530 . _:genid161469 a owl:Class ; owl:intersectionOf (obo:UBERON_0006800 [ a owl:Restriction ; owl:onProperty obo:RO_0002220 ; owl:someValuesFrom obo:UBERON_0013691 ] ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:18815700" . _:genid161501 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0007690 . _:genid161507 a owl:Restriction ; owl:onProperty obo:RO_0002202 ; owl:someValuesFrom obo:UBERON_0004873 . _:genid161510 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001641 . _:genid161512 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0005475 . _:genid161514 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0007160 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002474 ; owl:annotatedTarget obo:CL_0002469 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002474 ; owl:annotatedTarget "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." . _:genid161572 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002316 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:18846414" . _:genid161666 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002084 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002476 ; owl:annotatedTarget obo:CL_0000864 . _:genid161675 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002080 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002476 ; owl:annotatedTarget "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." . _:genid161683 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0036285 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:19047345" . _:genid161711 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0011143 . _:genid161732 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001621 . _:genid161740 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002110 . _:genid161748 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001529 . _:genid161756 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001533 . _:genid161766 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000159 . _:genid161768 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001007 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002477 ; owl:annotatedTarget obo:CL_0000864 . _:genid161776 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001222 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002477 ; owl:annotatedTarget "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." . _:genid161784 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001223 . _:genid161792 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002012 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:19244483" . _:genid161800 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0003889 . _:genid161810 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000057 . _:genid161818 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000996 . _:genid161826 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000304 . _:genid161833 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002285 . _:genid161840 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002289 . _:genid161847 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002286 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002478 ; owl:annotatedTarget obo:CL_0002477 . _:genid161854 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002422 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002478 ; owl:annotatedTarget "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." . _:genid161861 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002291 . _:genid161869 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0005282 . _:genid161876 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0010230 . _:genid161884 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0002393 . _:genid161892 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001697 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:19544990" . _:genid161900 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001530 . _:genid161908 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000948 . _:genid161910 a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0002406 . _:genid161912 a owl:Restriction ; owl:onProperty obo:RO_0002371 ; owl:someValuesFrom obo:UBERON_0004292 . _:genid161921 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001849 . _:genid161929 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001850 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002479 ; owl:annotatedTarget obo:CL_0002477 . _:genid161937 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001333 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002479 ; owl:annotatedTarget "An adipose macrophage that does not express MHC-II but is F4/80-positive." . _:genid161945 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001334 . _:genid161972 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0015482 . _:genid161980 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001215 . _:genid161996 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0018252 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:19628332" . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002480 ; owl:annotatedTarget "A goblet cell located in the nasal epithelium." . _:genid162004 a owl:Restriction ; owl:onProperty obo:RO_0002376 ; owl:someValuesFrom obo:UBERON_0001072 . _:genid162044 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_1000024 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002482 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:tfm", "MP:0009386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002482 ; owl:annotatedTarget "A melanocyte that produces pigment in the dermis." . _:genid162065 a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0001530 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:19812358" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002483 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0004381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002483 ; owl:annotatedTarget "A melanocyte that produces pigment within the hair follicle." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002484 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0009388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002484 ; owl:annotatedTarget "A melanocyte that produces pigment in the epithelium." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "PMID:30398859" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002485 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0010190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002485 ; owl:annotatedTarget "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Reaxys:3648446" . [] oboInOwl:hasDbXref "GOC:tfm", "MP:0002407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002489 ; owl:annotatedTarget "A thymocyte that lacks expression of CD4 and CD8." . [] oboInOwl:hasDbXref "MP:0002407" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002489 ; owl:annotatedTarget "CD4-CD8- T cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002491 ; owl:annotatedTarget "A specialized cell involved in auditory sensory perception." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Sulfate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002494 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002494 ; owl:annotatedTarget "A cell located in the heart, including both muscle and non muscle cells." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002503 ; owl:annotatedTarget "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "sulfate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002504 ; owl:annotatedTarget "A smooth muscle cell of the intestine." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "sulfate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002507 ; owl:annotatedTarget obo:CL_0000990 . [] oboInOwl:hasDbXref "GOC:tfm", "http://www.immgen.org/index_content.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002507 ; owl:annotatedTarget "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "tetraoxidosulfate(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002518 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:hasDbXref "GOC:tfm", "KUPO:SJ" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002518 ; owl:annotatedTarget "An epithelial cell of the kidney." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002521 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002521 ; owl:annotatedTarget "A fat cell that is part of subcutaneous adipose tissue." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "tetraoxosulfate(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "An epithelial cell of the cervix." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervical canal epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervical canal of uterus epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervix epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "cervix of uterus epithelial cell" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "tetraoxosulfate(VI)" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervical canal" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervical canal of uterus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of cervix of uterus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of neck of uterus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "epithelial cell of uterine cervix" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "neck of uterus epithelial cell" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002535 ; owl:annotatedTarget "uterine cervix epithelial cell" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "SO4(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002536 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002536 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002536 ; owl:annotatedTarget "An epithelial cell that is part of the amnion." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20446274", "PMID:21339039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002537 ; owl:annotatedTarget "A mesenchymal stem cell of the amnion membrane." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "SULFATE ION" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget obo:CL_1000488 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0002538 ; owl:annotatedTarget "small bile duct cholangiocyte" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Sulfate anion(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002539 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002539 ; owl:annotatedTarget "A smooth muscle cell of the aorta." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002540 ; owl:annotatedTarget "A mesenchymal stem cell that is part of the bone marrow." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Sulfate dianion" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002541 ; owl:annotatedTarget "A mesenchymal stem cell of the chorionic membrane." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002543 ; owl:annotatedTarget "An endothelial cell that is part of the vein." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002546 ; owl:annotatedTarget "An endothelial progenitor cell that participates in angiogenesis during development." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Sulfate(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002547 ; owl:annotatedTarget obo:CL_1000306 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002547 ; owl:annotatedTarget "A fibroblast of the aortic adventitia." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "Sulfuric acid ion(2-)" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget obo:CL_0002494 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002548 ; owl:annotatedTarget "A fibroblast that is part of the heart." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002549 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002549 ; owl:annotatedTarget "A fibroblast that is part of the choroid plexus." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "[SO4](2-)" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002550 ; owl:annotatedTarget "A fibroblast that is part of the conjuctiva of the eye." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002551 ; owl:annotatedTarget obo:CL_0002620 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "sulphate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002552 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002553 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002553 ; owl:annotatedTarget "A fibroblast that is part of lung." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16189 ; owl:annotatedTarget "sulphate ion" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002554 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002554 ; owl:annotatedTarget "A fibroblast of the lymphatic system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002555 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002555 ; owl:annotatedTarget "A fibroblast that is part of the mammary gland." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002556 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002556 ; owl:annotatedTarget "A fibroblast of the periodontium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002557 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002557 ; owl:annotatedTarget "A fibroblast of pulmonary artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002559 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002559 ; owl:annotatedTarget "An animal cell that is part of a hair follicle." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002563 ; owl:annotatedTarget "An epithelial cell of the intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002564 ; owl:annotatedTarget "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002569 ; owl:annotatedTarget "A mesenchymal stem cell of the umbilical cord." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002570 ; owl:annotatedTarget "A mesenchymal stem cell of adipose tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002571 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002571 ; owl:annotatedTarget "A mesenchymal stem cell of liver." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002572 ; owl:annotatedTarget obo:CL_0000134 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002572 ; owl:annotatedTarget "A mesenchymal stem cell of the vertebrae." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002574 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002574 ; owl:annotatedTarget "A stromal cell of the pancreas." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002575 ; owl:annotatedTarget obo:CL_0000669 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002575 ; owl:annotatedTarget "A pericyte of the central nervous system." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002577 ; owl:annotatedTarget obo:CL_0000349 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002577 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002577 ; owl:annotatedTarget "An epithelial cell of the placenta." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget obo:CL_0002518 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget obo:CL_0002681 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002584 ; owl:annotatedTarget "An epithelial cell of the kidney cortex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002585 ; owl:annotatedTarget "A blood vessel endothelial cell that is part of the retina." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002586 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Beilstein:635724" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002586 ; owl:annotatedTarget "An epithelial cell of the retinal pigmented epithelium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002589 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002589 ; owl:annotatedTarget "A smooth muscle cell of the bachiocephalic vasculature." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "CAS:57-13-6" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002590 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002590 ; owl:annotatedTarget "A vascular associated smooth muscle cell of the brain vasculature." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002591 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002591 ; owl:annotatedTarget "A smooth muscle of the pulmonary artery." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "CAS:57-13-6" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002592 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002592 ; owl:annotatedTarget "A smooth muscle cell of the coronary artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002593 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "CAS:57-13-6" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002593 ; owl:annotatedTarget "A smooth muscle of the internal thoracic artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002594 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002594 ; owl:annotatedTarget "A smooth muscle cell of the umbilical artery." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Drug_Central:4264" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002595 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002595 ; owl:annotatedTarget "A smooth muscle cell of the subclavian artery." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002596 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002596 ; owl:annotatedTarget "Smooth muscle cell of the carotid artery." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Gmelin:1378" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002597 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002597 ; owl:annotatedTarget "A smooth muscle cell of the bladder." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002598 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "PMID:18037357" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002599 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002599 ; owl:annotatedTarget "A smooth muscle cell of the esophagus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002600 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002600 ; owl:annotatedTarget "A smooth muscle cell of the trachea." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002601 ; owl:annotatedTarget "A smooth muscle cell of the uterus." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Reaxys:635724" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002602 ; owl:annotatedTarget obo:CL_0002320 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002603 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002603 ; owl:annotatedTarget "An astrocyte of the cerebellum." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "UM-BBD_compID:c0165" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002604 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7258-9596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002604 ; owl:annotatedTarget "An astrocyte that is part of the hippocampus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002605 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "UREA" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002605 ; owl:annotatedTarget "An astrocyte of the cerebral cortex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002606 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002606 ; owl:annotatedTarget "An astrocyte of the spinal cord." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002607 ; owl:annotatedTarget "A neural crest cell that gives rise to cells of the enteric nervous system." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Urea" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002608 ; owl:annotatedTarget "A neuron with a soma found in the hippocampus." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002610 ; owl:annotatedTarget obo:CL_0000117 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002610 ; owl:annotatedTarget "A neuron of the raphe nuclei." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "urea" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002612 ; owl:annotatedTarget obo:CL_0000117 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002612 ; owl:annotatedTarget "A neuron of the ventral spinal cord." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002613 ; owl:annotatedTarget obo:CL_0000117 . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "urea" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002613 ; owl:annotatedTarget "A neuron of the striatum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002614 ; owl:annotatedTarget obo:CL_0000117 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002614 ; owl:annotatedTarget "A neuron of the substantia nigra." . [] oboInOwl:hasDbXref "PPDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "1728" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002617 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002617 ; owl:annotatedTarget "A fat cell that is part of the breast." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002620 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002620 ; owl:annotatedTarget "A fibroblast of skin." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Carbamide" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002621 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002621 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002622 ; owl:annotatedTarget obo:CL_0000499 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "E927b" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002622 ; owl:annotatedTarget "A stromal cell of the prostate." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002623 ; owl:annotatedTarget obo:CL_0000622 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002623 ; owl:annotatedTarget "An acinar cell of salivary gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "H2NC(O)NH2" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002625 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002625 ; owl:annotatedTarget "A cell of the seminiferous tubule epithelium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002631 ; owl:annotatedTarget obo:CL_0002368 . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Harnstoff" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002632 ; owl:annotatedTarget obo:CL_0002368 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002634 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002634 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "Karbamid" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002634 ; owl:annotatedTarget "An epithelial cell of the anal column." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002637 ; owl:annotatedTarget "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "carbamide" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002656 ; owl:annotatedTarget "A glandular epithelial cell of the endometrium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget obo:CL_0000150 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget obo:CL_0002252 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002657 ; owl:annotatedTarget "A glandular epithelial cell of the esophagus." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "carbonyldiamide" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002658 ; owl:annotatedTarget obo:CL_0000150 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002658 ; owl:annotatedTarget "A glandular epithelial cell of the large intestine." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002659 ; owl:annotatedTarget obo:CL_0000150 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002659 ; owl:annotatedTarget "A glandular epithelial cell that is part of the stomach." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "ur" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002663 ; owl:annotatedTarget obo:CL_0002074 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002663 ; owl:annotatedTarget "A myocardial endocrine cell that is part of the atrium." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20959166", "PMID:21148186" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002672 ; owl:annotatedTarget "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16199 ; owl:annotatedTarget "uree" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:18816858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002673 ; owl:annotatedTarget "A skeletal muscle cell that is part of the tongue." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:17407019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002676 ; owl:annotatedTarget "A neuroblast derived from a neural crest cell." . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:21739668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002678 ; owl:annotatedTarget "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002679 ; owl:annotatedTarget obo:CL_0000542 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:20023630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002679 ; owl:annotatedTarget "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002680 ; owl:annotatedTarget obo:CL_0000696 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:2420136", "PMID:728970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0002680 ; owl:annotatedTarget "A PP cell found in intestine." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0002681 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005000 ; owl:annotatedTarget obo:CL_0000402 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005000 ; owl:annotatedTarget "A CNS interneuron located in the spinal cord." . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005009 ; owl:annotatedTarget "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005012 ; owl:annotatedTarget "A ciliated epithelial cell with many cilia." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005020 ; owl:annotatedTarget obo:CL_0000048 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005020 ; owl:annotatedTarget "Lymphatic progenitor cells." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0005022 ; owl:annotatedTarget obo:CL_0005020 . [] oboInOwl:hasDbXref "CL:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005022 ; owl:annotatedTarget "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "Beilstein:147911" . [] oboInOwl:hasDbXref "ZFIN:CVS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005024 ; owl:annotatedTarget "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." . [] oboInOwl:hasDbXref "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0005026 ; owl:annotatedTarget "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." . [] oboInOwl:hasDbXref "GO_REF:0000034", "PMCID:PMC2737325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007000 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007001 ; owl:annotatedTarget "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0007001 ; owl:annotatedTarget "scleroblast" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "CAS:73-40-5" . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007002 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into a cementoblast." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007003 ; owl:annotatedTarget "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." . [] oboInOwl:hasDbXref "UBERONREF:0000002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007004 ; owl:annotatedTarget "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007009 ; owl:annotatedTarget "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "CAS:73-40-5" . [] oboInOwl:hasDbXref "CL:MAH" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0007011 ; owl:annotatedTarget "Neuron that is part of the enteric nervous system." . [] oboInOwl:hasDbXref "GOC:DOS" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008000 ; owl:annotatedTarget "Any muscle cell in which the fibers are not organised into sarcomeres." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008001 ; owl:annotatedTarget "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "CAS:73-40-5" . [] oboInOwl:hasDbXref "GOC:tfm", "ISBN:0323052908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008002 ; owl:annotatedTarget "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "Gmelin:431879" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008007 ; owl:annotatedTarget "A muscle cell that is part of some visceral muscle." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008008 ; owl:annotatedTarget "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "PMID:8070089" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008009 ; owl:annotatedTarget "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." . [] oboInOwl:hasDbXref "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008017 ; owl:annotatedTarget "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." . [] oboInOwl:hasDbXref "PMID:23303905" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_0008017 ; owl:annotatedTarget "myogenic precursor cell" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "Reaxys:147911" . [] oboInOwl:hasDbXref "PMID:18816864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008022 ; owl:annotatedTarget "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "2-amino-1,9-dihydro-6H-purin-6-one" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008024 ; owl:annotatedTarget "An endocrine cell that is part of the pancreas." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "GUANINE" . [] oboInOwl:hasDbXref "PMID:30429548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008033 ; owl:annotatedTarget "A pericyte of the decidual vasculature." . [] oboInOwl:hasDbXref "Wiki:Mural_cell&oldid=930603194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0008034 ; owl:annotatedTarget "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "Guanine" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0009000 ; owl:annotatedTarget obo:CL_0000101 . [] oboInOwl:hasDbXref "GOC:nv", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009000 ; owl:annotatedTarget "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "guanine" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009004 ; owl:annotatedTarget "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009006 ; owl:annotatedTarget "An enteroendocrine cell that is located in the small intestine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "2-Amino-6-hydroxypurine" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009018 ; owl:annotatedTarget "A lymphocyte that resides in the lamina propria of the large intestine." . [] oboInOwl:hasDbXref "PMID:29449449", "https://orcid.org/0000-0002-3163-0115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009019 ; owl:annotatedTarget "A kidney cortical cell that is part of the nephrogenic zone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "2-amino-6-oxopurine" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009021 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the large intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009022 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the small intestine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "G" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009024 ; owl:annotatedTarget "A mesothelial cell that is part of the small intestine." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009025 ; owl:annotatedTarget "A mesothelial cell that is part of the colon." . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16235 ; owl:annotatedTarget "Gua" . [] oboInOwl:hasDbXref "PMID:8011279", "http://orcid.org/0000-0003-4183-8865/", "https://www.arppress.org/v/vspfiles/assets/images/Chapter1T25LymphNodes.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009037 ; owl:annotatedTarget "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009038 ; owl:annotatedTarget "A macrophage that is located in the colon." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009039 ; owl:annotatedTarget "A goblet cell that is located in the colon." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009040 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the colon." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16247 ; owl:annotatedTarget "Phospholipid" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009042 ; owl:annotatedTarget "An enteroendocrine cell that is located in the colon." . [] oboInOwl:hasDbXref "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009044 ; owl:annotatedTarget "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16247 ; owl:annotatedTarget "a phospholipid derivative" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009045 ; owl:annotatedTarget "A B cell found in the lymph node medullary sinus." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009046 ; owl:annotatedTarget "A T cell found in the lymph node medullary sinus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16247 ; owl:annotatedTarget "phospholipids" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009047 ; owl:annotatedTarget "A macrophage found in the medullary sinus of the lymph node." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009048 ; owl:annotatedTarget "A macrophage that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009050 ; owl:annotatedTarget "A B cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009051 ; owl:annotatedTarget "A T cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009052 ; owl:annotatedTarget "A smooth muscle cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009053 ; owl:annotatedTarget "A stromal cell found in the lamina propria of the anorectum." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Causality" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002410 ; owl:annotatedTarget "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009057 ; owl:annotatedTarget "A goblet cell that is located in the anorectum." . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009063 ; owl:annotatedTarget "An enteroendocrine cell that is located in the anorectum." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "Beilstein:1789963" . [] oboInOwl:hasDbXref "http://orcid.org/0000-0003-3440-1876" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009066 ; owl:annotatedTarget "A stratified squamous epithelial cell that is part of the anal canal." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009084 ; owl:annotatedTarget "An epithelial cell that is part of an endometrial gland." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "CAS:14721-66-5" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009086 ; owl:annotatedTarget "An endothelial cell that is part of a respiratory system lymphatic vessel." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009089 ; owl:annotatedTarget "A pericyte cell that is part of a lung." . [] oboInOwl:hasDbXref "PMID:21181888", "http://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009091 ; owl:annotatedTarget "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "CAS:14721-66-5" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009092 ; owl:annotatedTarget "An endothelial cell that is part of a placenta." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009093 ; owl:annotatedTarget "A smooth muscle cell that is part of a placenta." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01020251" . [] oboInOwl:hasDbXref "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009094 ; owl:annotatedTarget "An endothelial cell that is part of a hepatic portal vein." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009095 ; owl:annotatedTarget "An endothelial cell that is part of a uterus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "PMID:12187408" . [] oboInOwl:hasDbXref "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009097 ; owl:annotatedTarget "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." . [] oboInOwl:hasDbXref "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009100 ; owl:annotatedTarget "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "PMID:17956237" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-7655-4833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0009115 ; owl:annotatedTarget "An endothelial cell located in a lymph node lymphatic vessel." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "PMID:9819701" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "Reaxys:1789963" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "3,7,11,15-tetramethylhexadecanoic acid" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010011 ; owl:annotatedTarget "A GABAergic interneuron whose soma is located in the cerebral cortex." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "Phytanic acid" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010012 ; owl:annotatedTarget "A CNS neuron of the cerebral cortex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "3,7,11,15-Tetramethyl-hexadecansaeure" . [] oboInOwl:hasDbXref "PMID:12486170", "PMID:29265764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0010022 ; owl:annotatedTarget "A neuron that has its soma in the heart." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "3,7,11,15-tetramethyl hexadecanoic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0011001 ; owl:annotatedTarget obo:CL_0000100 . [] oboInOwl:hasDbXref "GOC:nv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011001 ; owl:annotatedTarget "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "GOC:nv", "PMID:29724907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011005 ; owl:annotatedTarget "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16285 ; owl:annotatedTarget "3,7,11,15-tetramethyl-hexadecanoic acid" . [] oboInOwl:hasDbXref "GOC:NV", "PMID:11687492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011007 ; owl:annotatedTarget "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011012 ; owl:annotatedTarget "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." . [] oboInOwl:hasDbXref "PMID:30612620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011013 ; owl:annotatedTarget "A sperm cell that is cabaple of motion (motility)." . [] oboInOwl:hasDbXref "PMID:30612620", "https://www.lexico.com/en/definition/flagellum" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011016 ; owl:annotatedTarget "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." . [] oboInOwl:hasDbXref "PMID:16285891" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011024 ; owl:annotatedTarget "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." . [] oboInOwl:hasDbXref "PMID:26544946" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0011025 ; owl:annotatedTarget "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." . [] oboInOwl:hasDbXref "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011026 ; owl:annotatedTarget "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." . [] oboInOwl:hasDbXref "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011027 ; owl:annotatedTarget "Any fibroblast that is part of skeletal muscle tissue." . [] oboInOwl:hasDbXref "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011030 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of the dermis." . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011101 ; owl:annotatedTarget "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011108 ; owl:annotatedTarget "Epithelial cell that is part of the colon epithelium." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "Beilstein:80811" . [] oboInOwl:hasDbXref "GOC:NV" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011113 ; owl:annotatedTarget "Neuron found in the spiral ganglion." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0011115 ; owl:annotatedTarget "A cell that, by division or terminal differentiation, can give rise to other cell types." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "CAS:344-25-2" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0012000 ; owl:annotatedTarget obo:CL_0000127 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_0012001 ; owl:annotatedTarget obo:CL_0000117 . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "CAS:344-25-2" . [] oboInOwl:hasDbXref "PMID:33842835", "http://orcid.org/0000-0001-7772-9578" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017002 ; owl:annotatedTarget "A neuroendocrine cell that is part of the prostate epithelium." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "Gmelin:833984" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017500 ; owl:annotatedTarget "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017502 ; owl:annotatedTarget "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:19023642" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017503 ; owl:annotatedTarget "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017504 ; owl:annotatedTarget "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:20023020" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0017505 ; owl:annotatedTarget "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:20959625" . [] oboInOwl:hasDbXref "PMID:15109561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019017 ; owl:annotatedTarget "A smooth muscle cell that is part of any lymphatic vessel." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:21374575" . [] oboInOwl:hasDbXref "PMID:9108778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019018 ; owl:annotatedTarget "A smooth muscle cell that is part of any blood vessel." . [] oboInOwl:hasDbXref "PMID:10853867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019019 ; owl:annotatedTarget "A smooth muscle cell that is part of the tracheobronchial tree." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:21563681" . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019020 ; owl:annotatedTarget "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." . [] oboInOwl:hasDbXref "PMID:23720296" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019020 ; owl:annotatedTarget "large bile duct cholangiocyte" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:22475019" . [] oboInOwl:hasDbXref "PMID:27423426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "periportal LSEC" . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019021 ; owl:annotatedTarget "periportal hepatic sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "PMID:27423426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "central venous hepatic sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "PMID:28287163" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019022 ; owl:annotatedTarget "pericentral LSEC" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "PMID:22479580" . [] oboInOwl:hasDbXref "PMID:1996606", "PMID:24942678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_0019031 ; owl:annotatedTarget "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." . [] oboInOwl:hasDbXref "PMID:1996606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_0019031 ; owl:annotatedTarget "intestinal goblet cell" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "Reaxys:80811" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "D-PROLINE" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "D-Proline" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000147 ; owl:annotatedTarget "A cell that is part of a cardiac valve." . [] oboInOwl:hasDbXref "PMID:30796046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000147 ; owl:annotatedTarget "heart valve cell" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "D-proline" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "(2R)-pyrrolidine-2-carboxylic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget "A smooth muscle cell that is part of the small intestine." . [] oboInOwl:hasDbXref "FMA:15050" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000275 ; owl:annotatedTarget "non-striated muscle fiber of small intestine" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "(R)-2-Carboxypyrrolidine" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget "A smooth muscle cell that is part of the duodenum." . [] oboInOwl:hasDbXref "FMA:15058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000276 ; owl:annotatedTarget "non-striated muscle fiber of duodenum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget "A smooth muscle cell that is part of the jejunum." . [] oboInOwl:hasDbXref "FMA:15062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000277 ; owl:annotatedTarget "non-striated muscle fiber of jejunum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "(R)-pyrrolidine-2-carboxylic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget obo:CL_1000275 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget "A smooth muscle cell that is part of the ileum." . [] oboInOwl:hasDbXref "FMA:15066" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000278 ; owl:annotatedTarget "non-striated muscle fiber of ileum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "D-Prolin" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget "A smooth muscle cell that is part of the large intestine." . [] oboInOwl:hasDbXref "FMA:15653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000279 ; owl:annotatedTarget "non-striated muscle fiber of large intestine" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000280 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000280 ; owl:annotatedTarget "A smooth muscle cell that is part of the colon." . [] oboInOwl:hasDbXref "FMA:15663" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000280 ; owl:annotatedTarget "non-striated muscle fiber of colon" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16313 ; owl:annotatedTarget "DPR" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget "A smooth muscle cell that is part of the descending colon." . [] oboInOwl:hasDbXref "FMA:17520" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000284 ; owl:annotatedTarget "non-striated muscle fiber of descending colon" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget obo:CL_1000280 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget "A smooth muscle cell that is part of the sigmoid colon." . [] oboInOwl:hasDbXref "FMA:17521" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000285 ; owl:annotatedTarget "non-striated muscle fiber of sigmoid colon" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000286 ; owl:annotatedTarget obo:CL_0002504 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000286 ; owl:annotatedTarget "A smooth muscle cell that is part of the rectum." . [] oboInOwl:hasDbXref "FMA:17522" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000286 ; owl:annotatedTarget "non-striated muscle fiber of rectum" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000296 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000296 ; owl:annotatedTarget "An epithelial cell that is part of the urethra." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "Beilstein:8538277" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000298 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000298 ; owl:annotatedTarget "A mesothelial cell that is part of the dura mater." . [] oboInOwl:hasDbXref "FMA:256516" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000298 ; owl:annotatedTarget "squamous mesothelial cell of dura mater" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000303 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "CAS:9004-61-9" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000303 ; owl:annotatedTarget "A fibroblast that is part of the areolar connective tissue." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000306 ; owl:annotatedTarget obo:CL_0000057 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000306 ; owl:annotatedTarget "A fibroblast that is part of the tunica adventitia of artery." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "CAS:9004-61-9" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000307 ; owl:annotatedTarget "A fibroblast that is part of the dense regular elastic tissue." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "A fat cell that is part of the epicardial fat." . [] oboInOwl:hasDbXref "FMA:261293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "adipocyte of epicardial fat" . [] oboInOwl:hasDbXref "FMA:261293" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000309 ; owl:annotatedTarget "epicardial fat cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "PMID:11122186" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "A fat cell that is part of the epicardial fat of right ventricle." . [] oboInOwl:hasDbXref "FMA:261297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "epicardial adipocyte of right ventricle" . [] oboInOwl:hasDbXref "FMA:261297" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000310 ; owl:annotatedTarget "epicardial fat cell of right ventricle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "PMID:18056362" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget obo:CL_0000136 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "A fat cell that is part of the epicardial fat of left ventricle." . [] oboInOwl:hasDbXref "FMA:261300" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "epicardial adipocyte of left ventricle" . [] oboInOwl:hasDbXref "FMA:261300" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000311 ; owl:annotatedTarget "epicardial fat cell of left ventricle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "PMID:18290544" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of bronchus." . [] oboInOwl:hasDbXref "FMA:263032" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000312 ; owl:annotatedTarget "goblet cell of epithelium of bronchus" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000313 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of stomach." . [] oboInOwl:hasDbXref "FMA:263035" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000313 ; owl:annotatedTarget "goblet cell of epithelium of stomach" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "Reaxys:8187837" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000317 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of intestinal villus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "Hyaluronic acid" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000320 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of large intestine." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000322 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of pancreatic duct." . [] oboInOwl:hasDbXref "FMA:263058" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000322 ; owl:annotatedTarget "goblet cell of epithelium of pancreatic duct" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "Hyaluronsaeure" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000323 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of pyloric gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000324 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of duodenum." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000325 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of jejunum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "acide hyaluronique" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000326 ; owl:annotatedTarget "A goblet cell that is part of the epithelium proper of ileum." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget "A goblet cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "acido hialuronico" . [] oboInOwl:hasDbXref "FMA:263075" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000329 ; owl:annotatedTarget "goblet cell of epithelium of trachea" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000330 ; owl:annotatedTarget obo:CL_0000313 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000330 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of trachea." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16336 ; owl:annotatedTarget "hyaluronan" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000331 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of bronchus." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000332 ; owl:annotatedTarget "A serous secreting cell that is part of the epithelium of terminal bronchiole." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "sulfides" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000361 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000361 ; owl:annotatedTarget "A transitional myocyte that is part of the interatrial septum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000362 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000362 ; owl:annotatedTarget "A transitional myocyte that is part of the interventricular septum." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "RSR" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000376 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000376 ; owl:annotatedTarget "A Purkinje myocyte that is part of the interventricular septum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "Sulfide" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "A melanocyte that is part of the eyelid." . [] oboInOwl:hasDbXref "FMA:59175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "eyelid melanocyte" . [] oboInOwl:hasDbXref "FMA:59175" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000391 ; owl:annotatedTarget "sebaceous gland of wolff" . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:3926620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "LSEC" . [] oboInOwl:hasDbXref "FMA:62911" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "endotheliocyte of hepatic sinusoid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "Thioether" . [] oboInOwl:hasDbXref "PMID:30348985" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000398 ; owl:annotatedTarget "liver sinusoidal endothelial cell" . [] oboInOwl:hasDbXref "FMA:67102", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "A muscle cell that is part of the sinoatrial node." . [] oboInOwl:hasDbXref "FMA:67102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "SA nodal myocyte" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "SA node cardiac muscle cell" . [] oboInOwl:hasDbXref "FMA:67102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "myocyte of sinoatrial node" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "sinoatrial node cell" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "organic sulfides" . [] oboInOwl:hasDbXref "FMA:67102" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000409 ; owl:annotatedTarget "sinuatrial node myocyte" . [] oboInOwl:hasDbXref "FMA:67106", "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "A muscle cell that is part of the atrioventricular node." . [] oboInOwl:hasDbXref "FMA:67106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV nodal myocyte" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV node cardiac muscle cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "AV node cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "atrioventricular node cell" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16385 ; owl:annotatedTarget "thioethers" . [] oboInOwl:hasDbXref "FMA:67106" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000410 ; owl:annotatedTarget "atrioventricular node myocyte" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000412 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000412 ; owl:annotatedTarget "An endothelial cell that is part of the arteriole." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000413 ; owl:annotatedTarget "A blood vessel endothelial cell that is part of an arterial endothelium." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000414 ; owl:annotatedTarget obo:CL_0002139 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000414 ; owl:annotatedTarget "An endothelial cell that is part of the venule." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000415 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000415 ; owl:annotatedTarget "An epithelial cell that is part of the gallbladder." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget "A chromaffin cell that is part of the adrenal gland." . [] oboInOwl:hasDbXref "GO:0061104" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000426 ; owl:annotatedTarget "adrenal chromaffin cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000427 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000427 ; owl:annotatedTarget "A chromaffin cell that is part of the adrenal cortex." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget obo:CL_0000723 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget "A somatic stem cell that is part of the epidermis." . [] oboInOwl:hasDbXref "FMA:70541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000428 ; owl:annotatedTarget "epidermal stem cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget "An epithelial cell that is part of the conjunctiva." . [] oboInOwl:hasDbXref "FMA:70552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000432 ; owl:annotatedTarget "epithelial cell of conjunctiva" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000434 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000434 ; owl:annotatedTarget "An epithelial cell that is part of the external acoustic meatus." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Beilstein:635807" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000435 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000435 ; owl:annotatedTarget "An epithelial cell that is part of the lacrimal duct." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000436 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000436 ; owl:annotatedTarget "An epithelial cell that is part of the lacrimal sac." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "CAS:302-72-7" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000437 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000437 ; owl:annotatedTarget "An epithelial cell that is part of the nasolacrimal duct." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "CAS:302-72-7" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget "A smooth muscle cell that is part of the ciliary body." . [] oboInOwl:hasDbXref "FMA:70610" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000443 ; owl:annotatedTarget "smooth muscle cell of ciliary body" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000444 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000444 ; owl:annotatedTarget "A mesothelial cell that is part of the anterior chamber of eyeball." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "CAS:302-72-7" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget obo:CL_0000646 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget "A basal cell that is part of the epithelium of esophagus." . [] oboInOwl:hasDbXref "FMA:70731" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000447 ; owl:annotatedTarget "basal cell of esophageal epithelium" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Drug_Central:4306" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000448 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000448 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000448 ; owl:annotatedTarget "An epithelial cell that is part of the sweat gland." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000449 ; owl:annotatedTarget "An epithelial cell that is part of the nephron." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Gmelin:2449" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget obo:CL_0000066 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget obo:CL_1000612 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget "An epithelial cell that is part of the glomerular capsule." . [] oboInOwl:hasDbXref "FMA:70966" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000450 ; owl:annotatedTarget "epithelial cell of Bowman's capsule" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget obo:CL_0000072 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget obo:CL_0002518 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget obo:CL_1001225 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget "An epithelial cell that is part of the collecting duct of renal tubule." . [] oboInOwl:hasDbXref "FMA:70982" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000454 ; owl:annotatedTarget "epithelial cell of renal collecting tubule" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000456 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000456 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000456 ; owl:annotatedTarget "A mesothelial cell that is part of the parietal peritoneum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000457 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Reaxys:635807" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000457 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000457 ; owl:annotatedTarget "A mesothelial cell that is part of the visceral peritoneum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget obo:CL_0000148 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "A melanocyte that is part of the skin of body." . [] oboInOwl:hasDbXref "FMA:72144" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000458 ; owl:annotatedTarget "skin melanocyte" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "2-aminopropanoic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000465 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000465 ; owl:annotatedTarget "A chromaffin cell that is part of the ovary." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000466 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Alanine" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000466 ; owl:annotatedTarget "A chromaffin cell that is part of the right ovary." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000467 ; owl:annotatedTarget obo:CL_0000166 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000467 ; owl:annotatedTarget "A chromaffin cell that is part of the left ovary." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "alanine" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000478 ; owl:annotatedTarget obo:CL_0002073 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000478 ; owl:annotatedTarget "A transitional myocyte that is part of the sinoatrial node." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000479 ; owl:annotatedTarget obo:CL_0002068 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000479 ; owl:annotatedTarget "A Purkinje myocyte that is part of the atrioventricular node." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "2-Aminopropanoic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000482 ; owl:annotatedTarget obo:CL_0002074 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000482 ; owl:annotatedTarget "A myocardial endocrine cell that is part of the interventricular septum." . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "2-Aminopropionic acid" . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "A smooth muscle cell that is part of the prostate gland." . [] oboInOwl:hasDbXref "FMA:84583" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000487 ; owl:annotatedTarget "smooth muscle fiber of prostate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "A" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget obo:CL_0000069 . [] oboInOwl:hasDbXref "GOC:tfm", "PMID:16550043", "PMID:18356246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000488 ; owl:annotatedTarget "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "ALA" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000490 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000490 ; owl:annotatedTarget "A mesothelial cell that is part of the peritoneum." . [] oboInOwl:hasDbXref "FMA:86736" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000490 ; owl:annotatedTarget "peritoneal mesothelial cell" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget "A mesothelial cell that is part of the pleura." . [] oboInOwl:hasDbXref "FMA:86737" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000491 ; owl:annotatedTarget "pleural mesothelial cell" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "Alanin" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000492 ; owl:annotatedTarget obo:CL_0000077 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000492 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000492 ; owl:annotatedTarget "A mesothelial cell that is part of the parietal pleura." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16449 ; owl:annotatedTarget "alanina" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000493 ; owl:annotatedTarget obo:CL_0002371 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000493 ; owl:annotatedTarget "A mesothelial cell that is part of the visceral pleura." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000494 ; owl:annotatedTarget "An epithelial cell that is part of a nephron tubule." . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1000495 ; owl:annotatedTarget "A goblet cell that is part of the small intestine." . [] oboInOwl:hasDbXref "FMA:86929" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1000495 ; owl:annotatedTarget "small intestinal goblet cell" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16498 ; owl:annotatedTarget "5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000497 ; owl:annotatedTarget obo:CL_0000548 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000500 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16498 ; owl:annotatedTarget "N-Acylneuraminate" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000504 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000505 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16498 ; owl:annotatedTarget "N-acylneuraminic acids" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000507 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000510 ; owl:annotatedTarget obo:CL_0002518 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000546 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000547 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000549 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000600 ; owl:annotatedTarget obo:CL_0000548 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000601 ; owl:annotatedTarget obo:CL_0000548 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000612 ; owl:annotatedTarget obo:CL_0002584 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000617 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000681 ; owl:annotatedTarget obo:CL_1000500 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000682 ; owl:annotatedTarget obo:CL_1000500 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000682 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000702 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000702 ; owl:annotatedTarget obo:CL_1000505 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000708 ; owl:annotatedTarget obo:CL_1000601 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget obo:CL_0005009 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000714 ; owl:annotatedTarget obo:CL_1000549 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget obo:CL_0005009 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000718 ; owl:annotatedTarget obo:CL_1000547 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000746 ; owl:annotatedTarget obo:CL_0002584 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000746 ; owl:annotatedTarget obo:CL_1000612 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000803 ; owl:annotatedTarget obo:CL_1000617 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000803 ; owl:annotatedTarget obo:CL_1000682 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000854 ; owl:annotatedTarget obo:CL_1000504 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000891 ; owl:annotatedTarget obo:CL_1000854 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "Beilstein:1900390" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000893 ; owl:annotatedTarget obo:CL_1000854 . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CAS:124-38-9" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000979 ; owl:annotatedTarget obo:CL_0000192 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1000979 ; owl:annotatedTarget obo:CL_1000601 . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CAS:124-38-9" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001005 ; owl:annotatedTarget obo:CL_1000746 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001005 ; owl:annotatedTarget obo:CL_1000892 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget obo:CL_0002584 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001006 ; owl:annotatedTarget obo:CL_1000891 . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CAS:124-38-9" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001045 ; owl:annotatedTarget obo:CL_0002584 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001045 ; owl:annotatedTarget obo:CL_1000891 . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "Drug_Central:4256" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001052 ; owl:annotatedTarget obo:CL_0002584 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001052 ; owl:annotatedTarget obo:CL_1000893 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001096 ; owl:annotatedTarget obo:CL_1000412 . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "Gmelin:989" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001097 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001135 ; owl:annotatedTarget obo:CL_1001045 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:10826146" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001138 ; owl:annotatedTarget obo:CL_1001045 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:11094503" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001213 ; owl:annotatedTarget obo:CL_0000071 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001213 ; owl:annotatedTarget obo:CL_1000413 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001214 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:11584085" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001217 ; owl:annotatedTarget obo:CL_0000359 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:11802652" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001225 ; owl:annotatedTarget obo:CL_1000497 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001318 ; owl:annotatedTarget obo:CL_0000669 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:14639145" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001319 ; owl:annotatedTarget obo:CL_0000548 . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001320 ; owl:annotatedTarget obo:CL_0000548 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:15050588" . [] oboInOwl:is_inferred "true" ; a owl:Axiom ; owl:annotatedProperty rdfs:subClassOf ; owl:annotatedSource obo:CL_1001431 ; owl:annotatedTarget obo:CL_0005009 . [] oboInOwl:hasDbXref "GOC:tfm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001433 ; owl:annotatedTarget "An epithelial cell of the exocrine pancreas." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:16591971" . [] oboInOwl:hasDbXref "PMID:18603310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001434 ; owl:annotatedTarget "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" . [] oboInOwl:hasDbXref "MP:0010802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001516 ; owl:annotatedTarget "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:16656478" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:16659660" . [] oboInOwl:hasDbXref "BTO:0001141" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001568 ; owl:annotatedTarget "PAEC cell" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001569 ; owl:annotatedTarget "An interneuron with a soma found in the hippocampus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:17190796" . [] oboInOwl:hasDbXref "NPX:PDR", "https://orcid.org/0000-0001-5208-3432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "A vascular endothelial cell found in colon blood vessels." . [] oboInOwl:hasDbXref "CALOHA:TS-2397" ; oboInOwl:hasSynonymType caloha-reqs-vetted:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "colon endothelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001572 ; owl:annotatedTarget "colonic endothelial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001573 ; owl:annotatedTarget "Cell of the nasopharyngeal epithelium." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:17448243" . [] oboInOwl:hasDbXref "CALOHA:TS-2398" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001573 ; owl:annotatedTarget "nasopharynx respiratory epithelial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "Squamous cell of uterine cervix epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "cervix, uterine squamous epithelial cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:17878298" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "uterine cervix squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1251" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001575 ; owl:annotatedTarget "uterine cervix squamous epithelial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "Squamous cell of oral epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral cavity mucosa squamous cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral cavity mucosa squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral mucosa squamous epithelial cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:17884085" . [] oboInOwl:hasDbXref "CALOHA:TS-1252" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001576 ; owl:annotatedTarget "oral mucosa squamous epithelial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "Squamous cell of tonsil epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsil squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsil squamous epithelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsillar squamous cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:19043767" . [] oboInOwl:hasDbXref "CALOHA:TS-1253" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001577 ; owl:annotatedTarget "tonsillar squamous epithelial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "Squamous cell of vaginal epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vagina squamous epithelial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vagina squamous epithelial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vaginal squamous cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:19259576" . [] oboInOwl:hasDbXref "CALOHA:TS-1254" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001578 ; owl:annotatedTarget "vaginal squamous epithelial cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "Glial cell of cerebral cortex." . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "brain cortex glial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "cerebral cortex glial cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1256" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001579 ; owl:annotatedTarget "cerebrum cortex glial cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:19854893" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "A glial cell that is part of the hippocampus." . [] oboInOwl:hasDbXref "CALOHA:TS-1257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "hippocampus glial cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1257" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001580 ; owl:annotatedTarget "hippocampus neuroglial cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:23384758" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001581 ; owl:annotatedTarget "Glial cell of lateral ventricle." . [] oboInOwl:hasDbXref "CALOHA:TS-1258" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001581 ; owl:annotatedTarget "lateral ventricle glial cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "Neuron of lateral ventricle." . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neural cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neuronal cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1261" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001582 ; owl:annotatedTarget "lateral ventricle neuronal cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:23828359" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "breast glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "breast glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1272" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001586 ; owl:annotatedTarget "mammary glandular cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:24258718" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "Glandular cell of uterine cervix epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix, uterine glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1273" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001587 ; owl:annotatedTarget "cervix, uterine glandular cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:8482095" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001588 ; owl:annotatedTarget "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1274" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001588 ; owl:annotatedTarget "colon glandular cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:8818713" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001589 ; owl:annotatedTarget "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." . [] oboInOwl:hasDbXref "CALOHA:TS-1275" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001589 ; owl:annotatedTarget "duodenum glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "Glandular cell of epididymal epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "epididymal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1276" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001590 ; owl:annotatedTarget "epididymis glandular cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:8869828" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "fallopian tube glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "fallopian tube glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1277" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001591 ; owl:annotatedTarget "uterine tube glandular cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:9611769" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "Glandular cell of gallbladder epithelium." . [] oboInOwl:hasDbXref "FMA:7202" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gall bladder glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gall bladder glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-1278" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001592 ; owl:annotatedTarget "gallbladder glandular cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "PMID:9730350" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1279" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "parathyroid gland glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1279" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001593 ; owl:annotatedTarget "parathyroid gland glandular cells" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "Reaxys:1900390" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." . [] oboInOwl:hasDbXref "CALOHA:TS-1281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "rectal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1281" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001595 ; owl:annotatedTarget "rectum glandular cells" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001596 ; owl:annotatedTarget "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "UM-BBD_compID:c0131" . [] oboInOwl:hasDbXref "CALOHA:TS-1282" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001596 ; owl:annotatedTarget "salivary gland glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget "Glandular cell of seminal vesicle epithelium." . [] oboInOwl:hasDbXref "CALOHA:TS-1283" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001597 ; owl:annotatedTarget "seminal vesicle glandular cells" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CARBON DIOXIDE" . [] oboInOwl:hasDbXref "NCI_Thesaurus:Small_Intestinal_Glandular_Cell", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small bowel glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small intestinal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1286" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001598 ; owl:annotatedTarget "small intestine glandular cells" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "Carbon dioxide" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." . [] oboInOwl:hasDbXref "CALOHA:TS-1242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "exocrine pancreas glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-1242" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001599 ; owl:annotatedTarget "pancreas exocrine glandular cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "carbon dioxide" . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "adrenal gland glandular cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "adrenal glandular cell" . [] oboInOwl:hasDbXref "CALOHA:TS-2177" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001601 ; owl:annotatedTarget "suprarenal gland glandular cell" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "Endothelial cells forming the walls of the capillaries within the cerebral cortex." . [] oboInOwl:hasDbXref "CALOHA:TS-2372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "cerebral cortex endothelial cells" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "dioxidocarbon" . [] oboInOwl:hasDbXref "CALOHA:TS-2372" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001602 ; owl:annotatedTarget "endothelial cells of cerebral cortex" . [] oboInOwl:hasDbXref "HPA:HPA", "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." . [] oboInOwl:hasDbXref "CALOHA:TS-0576" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001603 ; owl:annotatedTarget "lung macrophages" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "methanedione" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001606 ; owl:annotatedTarget "Keratinocyte from foreskin." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001607 ; owl:annotatedTarget "Chondrocyte forming the hyaline cartilage found in joints." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CO2" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001608 ; owl:annotatedTarget "Fibroblast from foreskin." . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001609 ; owl:annotatedTarget "Fibroblast from muscle organ." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "CO2" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." . [] oboInOwl:hasDbXref "CALOHA:TS-2109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "bone marrow hematopoietic cells" . [] oboInOwl:hasDbXref "CALOHA:TS-2109" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001610 ; owl:annotatedTarget "bone marrow poietic cells" . [] oboInOwl:hasDbXref "NPX:PDR" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_1001611 ; owl:annotatedTarget "Neuron of the cerebellum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "E 290" . [] oboInOwl:hasDbXref "CALOHA:TS-2359" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_1001611 ; owl:annotatedTarget "cerebellum neuron" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000000 ; owl:annotatedTarget "Any melanocyte that is part of a epidermis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "E-290" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000001 ; owl:annotatedTarget "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." . [] oboInOwl:hasDbXref "BTO:0002770", "NCIT:C32429", "PMID:30013421", "PMID:30429548", "Wiki:Decidual_cells&oldid=937509751", "Wiki:Decidualization&oldid=908981933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." . [] oboInOwl:hasDbXref "BTO:0002770", "NCIT:C32429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "decidua cell" . [] oboInOwl:hasDbXref "BTO:0005756", "PMID:11719592" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000002 ; owl:annotatedTarget "decidual stromal cell" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "E290" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000004 ; owl:annotatedTarget "Any cell that is part of a pituitary gland." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000005 ; owl:annotatedTarget "Any macroglial cell that is part of a brain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "R-744" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000006 ; owl:annotatedTarget "Any germinal center B cell that is part of a tonsil." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000007 ; owl:annotatedTarget "Chondrocyte forming the hyaline cartilage found in the knee joint." . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "[CO2]" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000008 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of a microvascular endothelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000010 ; owl:annotatedTarget "Any blood vessel endothelial cell that is part of a dermis." . [] oboInOwl:hasDbXref "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16526 ; owl:annotatedTarget "carbonic anhydride" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000011 ; owl:annotatedTarget "Any endothelial cell of lymphatic vessel that is part of a dermis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000012 ; owl:annotatedTarget "Any skin fibroblast that is part of a pedal digit skin." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000013 ; owl:annotatedTarget "Any skin fibroblast that is part of a skin of abdomen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000014 ; owl:annotatedTarget "Any skin fibroblast that is part of a upper leg skin." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16541 ; owl:annotatedTarget "Protein" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000015 ; owl:annotatedTarget "Any skin fibroblast that is part of a arm." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000016 ; owl:annotatedTarget "Any lung endothelial cell that is part of a microvascular endothelium." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16541 ; owl:annotatedTarget "a protein" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000017 ; owl:annotatedTarget "Any fibroblast that is part of a periodontal ligament." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000018 ; owl:annotatedTarget "Any endothelial cell of artery that is part of a coronary artery." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16541 ; owl:annotatedTarget "polypeptide chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000020 ; owl:annotatedTarget "Any native cell that is part of a inner cell mass." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000021 ; owl:annotatedTarget "Any native cell that is part of a sebaceous gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16541 ; owl:annotatedTarget "protein polypeptide chains" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000022 ; owl:annotatedTarget "Any native cell that is part of a cardiac septum." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000023 ; owl:annotatedTarget "Any interneuron that is part of a spinal cord ventral column." . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002432 ; owl:annotatedTarget (obo:RO_0002327 obo:BFO_0000066 ) . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "carbohydrate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000025 ; owl:annotatedTarget "Any oligodendrocyte that is part of a spinal cord." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000028 ; owl:annotatedTarget "Any glutamatergic neuron that is part of a cerebellum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "carbohydrates" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000029 ; owl:annotatedTarget "Any neuron that is part of a central nervous system." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000030 ; owl:annotatedTarget "Any native cell that is part of a hypothalamus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "Kohlenhydrat" . [] oboInOwl:hasDbXref "GOC:TermGenie", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000032 ; owl:annotatedTarget "A neuron that is part of a peripheral nervous system." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000033 ; owl:annotatedTarget "Any basal cell of epidermis that is part of a limb." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "Kohlenhydrate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000040 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a urinary bladder." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000041 ; owl:annotatedTarget "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "a carbohydrate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000042 ; owl:annotatedTarget "Any fibroblast that is part of a embryo." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000043 ; owl:annotatedTarget "Any pericyte cell that is part of a brain." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "carbohidrato" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000044 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a brain." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000045 ; owl:annotatedTarget "Any melanocyte that is part of a prepuce of penis." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "carbohidratos" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000046 ; owl:annotatedTarget "Any cardiac muscle cell that is part of a cardiac ventricle." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000047 ; owl:annotatedTarget "Any motor neuron that is part of a brainstem." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "glucide" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000051 ; owl:annotatedTarget "Any fibroblast that is part of a spleen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000052 ; owl:annotatedTarget "Any endothelial cell of artery that is part of a umbilical cord." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "glucides" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000053 ; owl:annotatedTarget "Any endothelial cell that is part of a spleen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000055 ; owl:annotatedTarget "Any dendritic cell that is part of a liver." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "glucido" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000059 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a prostate gland." . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." . [] oboInOwl:hasDbXref "PMID:31049600" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000060 ; owl:annotatedTarget "vCTB" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "glucidos" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000061 ; owl:annotatedTarget "Any mesenchymal stem cell that is part of a placenta." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000062 ; owl:annotatedTarget "Any capillary endothelial cell that is part of a placenta." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "hydrates de carbone" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000063 ; owl:annotatedTarget "Any fibroblast that is part of a female gonad." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000064 ; owl:annotatedTarget "Any epithelial cell that is part of a female gonad." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "saccharide" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000065 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a female urethra." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000066 ; owl:annotatedTarget "Any fibroblast that is part of a cardiac ventricle." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "saccharides" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000067 ; owl:annotatedTarget "Any fibroblast that is part of a cardiac atrium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000068 ; owl:annotatedTarget "Any fibroblast that is part of a pericardium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16646 ; owl:annotatedTarget "saccharidum" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000069 ; owl:annotatedTarget "Any fibroblast that is part of a gallbladder." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000070 ; owl:annotatedTarget "Any fibroblast that is part of a optic choroid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000071 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a breast." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000072 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a adipose tissue." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000073 ; owl:annotatedTarget "Any migratory neural crest cell that is part of a cardiac neural crest." . [] oboInOwl:hasDbXref "PMID:33060096" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_2000073 ; owl:annotatedTarget "cardiac neural crest cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000074 ; owl:annotatedTarget "Any leukocyte that is part of a spleen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000076 ; owl:annotatedTarget "Any vein endothelial cell that is part of a hindlimb stylopod." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000077 ; owl:annotatedTarget "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "Beilstein:4655977" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000078 ; owl:annotatedTarget "Any pericyte cell that is part of a placenta." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000079 ; owl:annotatedTarget "Any mesenchymal stem cell of the bone marrow that is part of a femur." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "Gmelin:324523" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000080 ; owl:annotatedTarget "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000081 ; owl:annotatedTarget "Any melanocyte of skin that is part of a skin of face." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "Reaxys:4655977" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000082 ; owl:annotatedTarget "Any melanocyte of skin that is part of a skin of prepuce of penis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000084 ; owl:annotatedTarget "Any goblet cell that is part of a conjunctiva." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "UM-BBD_compID:c0152" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000085 ; owl:annotatedTarget "Any mononuclear cell that is part of a umbilical cord." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000091 ; owl:annotatedTarget "Any microvascular endothelial cell that is part of a endometrial blood vessel." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "(2S)-2-hydroxypropanoate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000092 ; owl:annotatedTarget "Any keratinocyte that is part of a hair follicle." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000093 ; owl:annotatedTarget "Any fibroblast of lung that is part of a bronchus." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "(S)-lactate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_2000095 ; owl:annotatedTarget "Any hematopoietic stem cell that is part of a umbilical cord blood." . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:29802404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000000 ; owl:annotatedTarget "A ciliated epithelial cell of the esophagus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "(+)-lactate" . [] oboInOwl:hasDbXref "GOC:CellBLAST", "PMID:30096314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_3000004 ; owl:annotatedTarget "Peripheral sensory neuron." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "L(+)-lactate" . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4023057 ; owl:annotatedTarget "A GABAergic interneuron whose soma is located in the cerebellar cortex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "L-(+)-lactate" . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023068 ; owl:annotatedTarget "An excitatory neuron that has its soma located in the thalamic complex." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023072 ; owl:annotatedTarget "A cell that is part of the brain vasculature." . [] oboInOwl:hasDbXref "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16651 ; owl:annotatedTarget "L-lactate" . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023073 ; owl:annotatedTarget "A cell that is part of the choroid plexus." . [] oboInOwl:hasDbXref "DOI:10.1101/2022.10.12.511898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023079 ; owl:annotatedTarget "A GABAergic inhibitory neuron that is derived from the midbrain." . [] oboInOwl:hasDbXref "DOI:10.1007/3-540-29623-9_3240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023154 ; owl:annotatedTarget "A glial cell that myelinates axonal processes." . [] oboInOwl:hasDbXref "PMID:22865660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4023168 ; owl:annotatedTarget "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." . [] oboInOwl:hasDbXref "PMID:31819095", "http://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030000 ; owl:annotatedTarget "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." . [] oboInOwl:hasDbXref "PMID:31819095", "PMID:34082079" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030000 ; owl:annotatedTarget "Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002432 ; owl:annotatedTarget "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16670 ; owl:annotatedTarget "Peptide" . [] oboInOwl:hasDbXref "doi:10.1038/s41467-020-20082-7" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030001 ; owl:annotatedTarget "A stromal cell that is part of the thymus." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "An alpha-beta memory T cell with the phenotype CD45RA-positive." . [] oboInOwl:hasDbXref "PMID:16237082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "TEMRA" . [] oboInOwl:hasDbXref "PMID:16237082" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "effector memory RA T cell" . [] oboInOwl:hasDbXref "PMID:25104859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "TEMRA cell" . [] oboInOwl:hasDbXref "PMID:25104859" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "terminally differentiated effector memory CD45RA+ T cells" . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/T_cell#Memory_T_cells" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030002 ; owl:annotatedTarget "terminally differentiated effector memory cells re-expressing CD45RA" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16670 ; owl:annotatedTarget "peptides" . [] oboInOwl:hasDbXref , "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030022 ; owl:annotatedTarget "A fibroblast that is located in the renal medulla interstitium." . [] oboInOwl:hasDbXref "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030022 ; owl:annotatedTarget "It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis." . [] oboInOwl:hasDbXref "PMID:10559635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030025 ; owl:annotatedTarget "A fibroblast that is located in the renal cortical interstitium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16670 ; owl:annotatedTarget "Peptid" . [] oboInOwl:hasDbXref "PMID:16230044" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030025 ; owl:annotatedTarget "Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin." . [] oboInOwl:hasDbXref "https://doi.org/10.1016/j.cell.2020.08.013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030027 ; owl:annotatedTarget "An amacrine cell that uses GABA as a neurotransmitter." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16670 ; owl:annotatedTarget "peptido" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030029 ; owl:annotatedTarget "A lymphocyte located in blood." . [] oboInOwl:hasDbXref "PMID:24987007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030031 ; owl:annotatedTarget "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16670 ; owl:annotatedTarget "peptidos" . [] oboInOwl:hasDbXref , "PMID:25311230", "https://doi.org/10.1098/rsif.2017.0580", "https://doi.org/10.1161/ATVBAHA.120.314789", "https://doi.org/10.1161/JAHA.117.006339", "https://doi.org/10.2353/ajpath.2007.070251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." . [] oboInOwl:hasDbXref "PMID:25311230", "PMID:30796046" ; oboInOwl:hasSynonymType cl:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "VIC" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "valvular interstitial cell" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030032 ; owl:annotatedTarget "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis)." . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." . [] oboInOwl:hasDbXref "PMID:25311230", "PMID:30796046" ; oboInOwl:hasSynonymType cl:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "VEC" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "valvular endothelial cell" . [] oboInOwl:hasDbXref "PMID:25311230" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030033 ; owl:annotatedTarget "At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration." . [] oboInOwl:hasDbXref "PMID:18757316", "PMID:21364219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030034 ; owl:annotatedTarget "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_166902 ; owl:annotatedTarget "noradrenaline" . [] oboInOwl:hasDbXref , "DOI:10.1177/154405910208100806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030035 ; owl:annotatedTarget "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." . [] oboInOwl:hasSynonymType cl:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4030035 ; owl:annotatedTarget "DPSC" . [] oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z", "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4030040 ; owl:annotatedTarget "A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium." . [] oboInOwl:hasDbXref "ttps://www.nature.com/articles/s41591-020-1040-z" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4030040 ; owl:annotatedTarget "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted." . [] oboInOwl:hasDbXref "PMID:28217126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033000 ; owl:annotatedTarget "A(n) endothelial cell that is part of a(n) venule of lymph node." . [] oboInOwl:hasDbXref "PMID:28217126" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033001 ; owl:annotatedTarget "A(n) endothelial cell that is part of a(n) arteriole of lymph node." . [] oboInOwl:hasDbXref "PMID:5487122", "PMID:9651178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033005 ; owl:annotatedTarget "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." . [] oboInOwl:hasDbXref "PMID:34030460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033008 ; owl:annotatedTarget "A(n) vein endothelial cell that is part of a(n) respiratory system." . [] oboInOwl:hasDbXref "PMID:35883599", "PMID:9520465", "https://www.proteinatlas.org/humanproteome/single+cell+type/squamous+epithelial+cells#suprabasalkeratinocytes" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033013 ; owl:annotatedTarget "A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1." . [] oboInOwl:hasDbXref "PMID:25236977", "PMID:33796062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." . [] oboInOwl:SynonymTypeProperty core:PLURAL ; oboInOwl:hasDbXref "PMID:33796062" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "retinal astroglia" . [] oboInOwl:hasDbXref "PMID:32555229", "PMID:33796062" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:CL_4033015 ; owl:annotatedTarget "In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive." . [] oboInOwl:hasDbXref "ISBN:9781260462982", "PMID:15347627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033017 ; owl:annotatedTarget "A smooth muscle cell that is part of a bronchiole." . [] oboInOwl:hasDbXref "PMID:33351116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "A megakaryocyte that is resident in the lung connective tissue." . [] oboInOwl:hasDbXref "PMID:33351116" ; oboInOwl:hasSynonymType cl:abbreviation, core:PLURAL ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033018 ; owl:annotatedTarget "lung MKs" . [] oboInOwl:hasDbXref "PMID:18931053", "PMID:29656943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033020 ; owl:annotatedTarget "A mucus secreting cell that is part of a submucosal gland of the trachea." . [] oboInOwl:hasDbXref "PMID:18931053" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033020 ; owl:annotatedTarget "tracheal submucosal gland mucous cell" . [] oboInOwl:hasDbXref "PMID:19965983" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "A mucus secreting cell of a submucosal gland of the bronchus." . [] oboInOwl:hasDbXref "PMID:5487122" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4033022 ; owl:annotatedTarget "bronchial gland mucous cell" . [] oboInOwl:hasDbXref "PMID:30864819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033037 ; owl:annotatedTarget "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Beilstein:608603" . [] oboInOwl:hasDbXref "DOI:10.1111/j.1096-3642.1981.tb01137.x", "PMID:10052456", "PMID:28655883", "http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4033049 ; owl:annotatedTarget "A taste receptor cell that is part of a taste bud of a tongue." . [] oboInOwl:hasDbXref "DOI:10.1016/s0022-5320(69)80043-2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4033049 ; owl:annotatedTarget "gustatory cell of tongue" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "CAS:73-24-5" . [] oboInOwl:hasDbXref "PMID:16336493", "PMID:17483847", "PMID:25975510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." . [] oboInOwl:hasDbXref "PMID:11169131", "PMID:25170211" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "enteric glial cell" . [] oboInOwl:SynonymTypeProperty ; oboInOwl:hasDbXref "PMID:11169131" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CL_4040002 ; owl:annotatedTarget "enteric glia" . [] oboInOwl:hasDbXref "PMID:1316350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." . [] oboInOwl:hasDbXref "PMID:9624168" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal alveolar pre-type II epithelial cell" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal pre-type 2 pneumocyte" . [] oboInOwl:hasDbXref "PMID:12114192" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CL_4040003 ; owl:annotatedTarget "fetal pre-type II alveolar epithelial cell" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000002 ; owl:annotatedTarget "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete", "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000003 ; owl:annotatedTarget "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "CAS:73-24-5" . [] oboInOwl:hasDbXref "PMID:12023280" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000016 ; owl:annotatedTarget "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." . [] a owl:Axiom ; rdfs:label "lactose + H2O => D-glucose + D-galactose" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0000016 ; owl:annotatedTarget "Reactome:R-HSA-189062" . [] a owl:Axiom ; rdfs:label "Defective LCT does not hydrolyze Lac" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0000016 ; owl:annotatedTarget "Reactome:R-HSA-5658001" . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000018 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000052 ; owl:annotatedTarget "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "CAS:73-24-5" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000070 ; owl:annotatedTarget "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000096 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000226 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0000226 ; owl:annotatedTarget "microtubule cytoskeleton organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0000226 ; owl:annotatedTarget "microtubule cytoskeleton organization and biogenesis" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Drug_Central:89" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000228 ; owl:annotatedTarget "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Gmelin:3903" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000262 ; owl:annotatedTarget "A chromosome found in the mitochondrion of a eukaryotic cell." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000271 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." . [] oboInOwl:hasDbXref "PMID:33139480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000272 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0815316194", "Reactome:69278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000278 ; owl:annotatedTarget "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:11985597" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000280 ; owl:annotatedTarget "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mcc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000313 ; owl:annotatedTarget "A ribosome contained within a subcellular membrane-bounded organelle." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000323 ; owl:annotatedTarget "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." . [] oboInOwl:hasDbXref "GOC:elh", "PMID:20404130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000785 ; owl:annotatedTarget "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:12829005" . [] oboInOwl:hasDbXref "PMID:32017156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000791 ; owl:annotatedTarget "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." . [] oboInOwl:hasDbXref "PMID:32017156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000792 ; owl:annotatedTarget "A compact and highly condensed form of chromatin that is refractory to transcription." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:elh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000819 ; owl:annotatedTarget "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000820 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:12951489" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0000821 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001501 ; owl:annotatedTarget "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." . [] oboInOwl:hasDbXref "GOC:mtg_mpo", "PMID:17572649" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001503 ; owl:annotatedTarget "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001505 ; owl:annotatedTarget "Any process that modulates levels of neurotransmitter." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001508 ; owl:annotatedTarget "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001523 ; owl:annotatedTarget "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:15063338" . [] oboInOwl:hasDbXref "ISBN:0878932453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001525 ; owl:annotatedTarget "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." . [] oboInOwl:hasSynonymType go:systematic_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001525 ; owl:annotatedTarget "blood vessel formation from pre-existing blood vessels" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:hjd", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001539 ; owl:annotatedTarget "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001558 ; owl:annotatedTarget "Any process that modulates the frequency, rate, extent or direction of cell growth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:15715490" . [] oboInOwl:hasDbXref "GOC:hjd", "UBERON:0001981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001568 ; owl:annotatedTarget "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001569 ; owl:annotatedTarget "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0001569 ; owl:annotatedTarget "patterning of blood vessels" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001573 ; owl:annotatedTarget "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001578 ; owl:annotatedTarget "A process that results in a parallel arrangement of microtubules." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001659 ; owl:annotatedTarget "A homeostatic process in which an organism modulates its internal body temperature." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001659 ; owl:annotatedTarget "thermoregulation" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001667 ; owl:annotatedTarget "Cell migration that is accomplished by extension and retraction of a pseudopodium." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:hjd", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001675 ; owl:annotatedTarget "The formation of the acrosome from the spermatid Golgi." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001675 ; owl:annotatedTarget "acrosome formation" . [] oboInOwl:hasDbXref "GOC:ajp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001676 ; owl:annotatedTarget "The chemical reactions and pathways involving a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons." . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001696 ; owl:annotatedTarget "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001701 ; owl:annotatedTarget "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "PMID:8070089" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001704 ; owl:annotatedTarget "The formation of the ectoderm, mesoderm and endoderm during gastrulation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001705 ; owl:annotatedTarget "The formation of ectoderm during gastrulation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001706 ; owl:annotatedTarget "The formation of the endoderm during gastrulation." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001706 ; owl:annotatedTarget "endoblast formation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001707 ; owl:annotatedTarget "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001763 ; owl:annotatedTarget "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Reaxys:608603" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001763 ; owl:annotatedTarget "branching morphogenesis" . [] oboInOwl:hasDbXref "CL:0000540", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001764 ; owl:annotatedTarget "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." . [] oboInOwl:hasDbXref "GOC:mgi_curators", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001773 ; owl:annotatedTarget "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." . [] oboInOwl:hasDbXref "GOC:mgi_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001775 ; owl:annotatedTarget "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001816 ; owl:annotatedTarget "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001816 ; owl:annotatedTarget "interferon production" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001816 ; owl:annotatedTarget "interferon secretion" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001816 ; owl:annotatedTarget "interleukin production" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001816 ; owl:annotatedTarget "interleukin secretion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "9H-purin-6-amine" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001817 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of production of a cytokine." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "ADENINE" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001818 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the rate of production of a cytokine." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001819 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of production of a cytokine." . [] oboInOwl:hasDbXref "GOC:ef", "ISBN:0198506732", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001820 ; owl:annotatedTarget "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0001820 ; owl:annotatedTarget "serotonin release" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Adenine" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001821 ; owl:annotatedTarget "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." . [] oboInOwl:hasDbXref "GOC:dph", "ISBN:0824072820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001838 ; owl:annotatedTarget "The morphogenesis of an embryonic epithelium into a tube-shaped structure." . [] oboInOwl:hasDbXref "GOC:dph", "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001841 ; owl:annotatedTarget "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001841 ; owl:annotatedTarget "neural tube morphogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001843 ; owl:annotatedTarget "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." . [] oboInOwl:hasDbXref "GOC:add", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001894 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "adenine" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001894 ; owl:annotatedTarget "tissue maintenance" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001906 ; owl:annotatedTarget "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149", "PMID:11911826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001909 ; owl:annotatedTarget "The directed killing of a target cell by a leukocyte." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11911826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001910 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "6-Aminopurine" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11911826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001911 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "A" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11911826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001912 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." . [] oboInOwl:hasDbXref "GOC:dph", "UBERON:0002409" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001944 ; owl:annotatedTarget "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001956 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." . [] oboInOwl:hasDbXref "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001957 ; owl:annotatedTarget "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Ade" . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0001957 ; owl:annotatedTarget "dermal ossification" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0001957 ; owl:annotatedTarget "intramembranous bone ossification" . [] oboInOwl:hasDbXref "GO_REF:0000034", "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001958 ; owl:annotatedTarget "Replacement ossification wherein bone tissue replaces cartilage." . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001959 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16708 ; owl:annotatedTarget "Adenin" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001959 ; owl:annotatedTarget "regulation of cytokine mediated signaling pathway" . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001960 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001960 ; owl:annotatedTarget "negative regulation of cytokine mediated signaling pathway" . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001961 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001961 ; owl:annotatedTarget "positive regulation of cytokine mediated signaling pathway" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001964 ; owl:annotatedTarget "An action or movement due to the application of a sudden unexpected stimulus." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_167114 ; owl:annotatedTarget "a 2-hydroxydicarboxylate" . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001976 ; owl:annotatedTarget "The regulation of blood pressure mediated by detection of stimuli and a neurological response." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0001976 ; owl:annotatedTarget "neurological process involved in regulation of systemic arterial blood pressure" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001977 ; owl:annotatedTarget "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0001977 ; owl:annotatedTarget "renal regulation of blood volume" . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001990 ; owl:annotatedTarget "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0001992 ; owl:annotatedTarget "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:tb", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002009 ; owl:annotatedTarget "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_cardio", "GOC:tb", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002016 ; owl:annotatedTarget "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0002016 ; owl:annotatedTarget "renin-angiotensin regulation of blood volume" . [] oboInOwl:hasDbXref "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002018 ; owl:annotatedTarget "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb", "PMID:10358008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002027 ; owl:annotatedTarget "Any process that modulates the frequency or rate of heart contraction." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0002027 ; owl:annotatedTarget "cardiac chronotropy" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002053 ; owl:annotatedTarget "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb", "PMID:12458206" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002087 ; owl:annotatedTarget "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0002087 ; owl:annotatedTarget "neurological control of breathing" . [] oboInOwl:hasDbXref "GOC:hjd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002185 ; owl:annotatedTarget "A protein complex having creatine kinase activity." . [] oboInOwl:hasDbXref "PMID:16236486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002187 ; owl:annotatedTarget "An octomeric protein complex having creatine kinase activity." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Beilstein:969212" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:16102575", "PMID:16166509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002200 ; owl:annotatedTarget "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002204 ; owl:annotatedTarget "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002204 ; owl:annotatedTarget "somatic recombination of immunoglobulin genes during immune response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:14991701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002208 ; owl:annotatedTarget "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002208 ; owl:annotatedTarget "somatic diversification of immunoglobulins during immune response" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "CAS:71-43-2" . [] oboInOwl:hasDbXref "GOC:add", "PMID:11807545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002225 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002228 ; owl:annotatedTarget "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002232 ; owl:annotatedTarget "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002232 ; owl:annotatedTarget "leukocyte chemotaxis during inflammatory response" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "CAS:71-43-2" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002233 ; owl:annotatedTarget "The movement of an immune cell in response to an external stimulus a part of an immune response." . [] oboInOwl:hasDbXref "GOC:add", "GOC:rl", "ISBN:0781735149", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002244 ; owl:annotatedTarget "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "CAS:71-43-2" . [] oboInOwl:hasDbXref "GOC:jal", "ISBN:0721601871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002246 ; owl:annotatedTarget "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002246 ; owl:annotatedTarget "healing during inflammatory response" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002246 ; owl:annotatedTarget "inflammatory response wound healing" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002250 ; owl:annotatedTarget "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." . [] oboInOwl:hasDbXref "ISBN:068340007X" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0002250 ; owl:annotatedTarget "acquired immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0002250 ; owl:annotatedTarget "immune memory response" . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002251 ; owl:annotatedTarget "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002252 ; owl:annotatedTarget "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Gmelin:1671" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002253 ; owl:annotatedTarget "Any process that initiates an immune response." . [] oboInOwl:hasDbXref "CL:0000763", "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002262 ; owl:annotatedTarget "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002263 ; owl:annotatedTarget "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002263 ; owl:annotatedTarget "cell activation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:11684179" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002269 ; owl:annotatedTarget "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002269 ; owl:annotatedTarget "leukocyte activation during inflammatory response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002274 ; owl:annotatedTarget "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002275 ; owl:annotatedTarget "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002275 ; owl:annotatedTarget "myeloid cell activation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:11993966" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002277 ; owl:annotatedTarget "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002277 ; owl:annotatedTarget "myeloid dendritic cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002284 ; owl:annotatedTarget "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:12857942" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002284 ; owl:annotatedTarget "myeloid dendritic cell differentiation during immune response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002285 ; owl:annotatedTarget "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002285 ; owl:annotatedTarget "lymphocyte activation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:14677922" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002286 ; owl:annotatedTarget "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002286 ; owl:annotatedTarget "T cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:add", "PMID:8717523" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002290 ; owl:annotatedTarget "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002290 ; owl:annotatedTarget "gamma-delta T cell activation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:15468289" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002292 ; owl:annotatedTarget "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002292 ; owl:annotatedTarget "T cell development involved in immune response" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002292 ; owl:annotatedTarget "T cell differentiation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:15935818" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002303 ; owl:annotatedTarget "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002303 ; owl:annotatedTarget "gamma-delta T cell development involved in immune response" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002303 ; owl:annotatedTarget "gamma-delta T cell differentiation during immune response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002309 ; owl:annotatedTarget "The expansion of a T cell population by cell division as part of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002309 ; owl:annotatedTarget "T cell proliferation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:16161967" . [] oboInOwl:hasDbXref "GOC:jal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002312 ; owl:annotatedTarget "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002312 ; owl:annotatedTarget "B cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:jal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002313 ; owl:annotatedTarget "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:17373369" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002313 ; owl:annotatedTarget "mature B cell development involved in immune response" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002313 ; owl:annotatedTarget "mature B cell differentiation during immune response" . [] oboInOwl:hasDbXref "GOC:jal", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002319 ; owl:annotatedTarget "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002319 ; owl:annotatedTarget "memory B cell development" . [] oboInOwl:hasDbXref "GOC:jal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002322 ; owl:annotatedTarget "The expansion of a B cell population by cell division following B cell activation during an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002322 ; owl:annotatedTarget "B cell proliferation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:18072742" . [] oboInOwl:hasDbXref "GOC:jal", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002335 ; owl:annotatedTarget "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002335 ; owl:annotatedTarget "mature cell development" . [] oboInOwl:hasDbXref "GOC:jal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002339 ; owl:annotatedTarget "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." . [] oboInOwl:hasDbXref "GOC:jal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002343 ; owl:annotatedTarget "Any B cell selection process that occurs in the periphery." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002344 ; owl:annotatedTarget "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:16730260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002349 ; owl:annotatedTarget "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:16730260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002351 ; owl:annotatedTarget "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:18407866" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002366 ; owl:annotatedTarget "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002366 ; owl:annotatedTarget "leukocyte activation during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:18409691" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002367 ; owl:annotatedTarget "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002367 ; owl:annotatedTarget "cytokine production during immune response" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002367 ; owl:annotatedTarget "cytokine secretion during immune response" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002376 ; owl:annotatedTarget "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002377 ; owl:annotatedTarget "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:18836923" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:9185563" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002381 ; owl:annotatedTarget "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002381 ; owl:annotatedTarget "immunoglobulin production during immune response" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002381 ; owl:annotatedTarget "immunoglobulin production involved in immune response" . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002384 ; owl:annotatedTarget "An immune response taking place in the liver." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002440 ; owl:annotatedTarget "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:19228219" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002441 ; owl:annotatedTarget "The regulated release of histamine by a cell as part of an inflammatory response." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002442 ; owl:annotatedTarget "The regulated release of serotonin by a cell as part of an inflammatory response." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002442 ; owl:annotatedTarget "serotonin release involved in inflammatory response" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002443 ; owl:annotatedTarget "Any process involved in the carrying out of an immune response by a leukocyte." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002444 ; owl:annotatedTarget "Any process involved in the carrying out of an immune response by a myeloid leukocyte." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:21325737" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002446 ; owl:annotatedTarget "Any process involved in the carrying out of an immune response by a neutrophil." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002449 ; owl:annotatedTarget "Any process involved in the carrying out of an immune response by a lymphocyte." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002456 ; owl:annotatedTarget "Any process involved in the carrying out of an immune response by a T cell." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_sensu", "ISBN:0781735149", "ISBN:1405196831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002460 ; owl:annotatedTarget "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002461 ; owl:annotatedTarget "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002465 ; owl:annotatedTarget "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:081533642X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002467 ; owl:annotatedTarget "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:15531770", "PMID:15771591", "PMID:16153240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002504 ; owl:annotatedTarget "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002507 ; owl:annotatedTarget "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:23088855" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002520 ; owl:annotatedTarget "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." . [] oboInOwl:hasDbXref "CL:0000738", "GOC:add", "PMID:16551264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002521 ; owl:annotatedTarget "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002522 ; owl:annotatedTarget "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:23222815" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002523 ; owl:annotatedTarget "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002523 ; owl:annotatedTarget "leukocyte migration during inflammatory response" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002526 ; owl:annotatedTarget "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." . [] oboInOwl:hasDbXref "GOC:add", "GOC:dph", "GOC:tb", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002532 ; owl:annotatedTarget "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:23534829" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002534 ; owl:annotatedTarget "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002536 ; owl:annotatedTarget "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002538 ; owl:annotatedTarget "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:6353911" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0002538 ; owl:annotatedTarget "arachidonic acid metabolite production involved in acute inflammatory response" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002539 ; owl:annotatedTarget "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." . [] oboInOwl:hasDbXref "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002544 ; owl:annotatedTarget "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." . [] oboInOwl:hasDbXref "GOC:add", "PMID:11696603", "PMID:15173832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002548 ; owl:annotatedTarget "The movement of a monocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:16102575", "PMID:16166509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002562 ; owl:annotatedTarget "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." . [] oboInOwl:hasDbXref "ISBN:0781735149", "PMID:16102575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002566 ; owl:annotatedTarget "The process in which immune receptor genes are diversified through somatic mutation." . [] oboInOwl:hasDbXref "GOC:add", "PMID:16551251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002573 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002574 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "PMID:8124204" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002577 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002578 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Reaxys:969212" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002579 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "UM-BBD_compID:c0142" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002580 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002581 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "BENZENE" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002582 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002634 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of germinal center formation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Benzene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002635 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "benzene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002636 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of germinal center formation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002637 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of immunoglobulin production." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "benzene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002638 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002639 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "benzene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002643 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of tolerance induction." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Benzen" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002644 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002645 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of tolerance induction." . [] oboInOwl:hasDbXref "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Benzine" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002652 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002653 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Benzol" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002654 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Bicarburet of hydrogen" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002658 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002659 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Coal naphtha" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002660 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002673 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Mineral naphtha" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002674 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Phene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002675 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002676 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Pyrobenzol" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002677 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002678 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "Pyrobenzole" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:12789499" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002679 ; owl:annotatedTarget "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "[6]annulene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002682 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an immune system process." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002683 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "benzole" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002684 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an immune system process." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002685 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of leukocyte migration." . [] oboInOwl:hasDbXref "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "cyclohexatriene" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002686 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." . [] oboInOwl:hasDbXref "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16716 ; owl:annotatedTarget "phenyl hydride" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002687 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002688 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002689 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002690 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002694 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of leukocyte activation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16733 ; owl:annotatedTarget "D-alpha-amino acid" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002695 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002696 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16733 ; owl:annotatedTarget "D-alpha-amino acids" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002697 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an immune effector process." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002698 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16733 ; owl:annotatedTarget "D-Amino acid" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002699 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an immune effector process." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16733 ; owl:annotatedTarget "D-alpha-amino acids" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002700 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002701 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002702 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002703 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002704 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002705 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002706 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "CAS:60-27-5" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002707 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002708 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "CAS:60-27-5" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002709 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "CAS:60-27-5" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002710 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002711 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:11256540" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002712 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002713 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:11981083" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002714 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002715 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002716 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:17422601" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002717 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002718 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:18182718" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002718 ; owl:annotatedTarget "regulation of cytokine production during immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002719 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002719 ; owl:annotatedTarget "negative regulation of cytokine production during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:19236048" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002720 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0002720 ; owl:annotatedTarget "positive regulation of cytokine production during immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:19715855" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002759 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002760 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:19968328" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002761 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002762 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:21775764" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002763 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002775 ; owl:annotatedTarget "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002776 ; owl:annotatedTarget "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22047975" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002784 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22121923" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002785 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002790 ; owl:annotatedTarget "The controlled release of a peptide from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002791 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of peptide secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22166252" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002792 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002793 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of peptide secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22207347" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002794 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22212624" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002795 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002796 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22223530" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002819 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an adaptive immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002820 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22331238" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002821 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22338083" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002822 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002823 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22349552" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002824 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002828 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of a type 2 immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22390548" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002828 ; owl:annotatedTarget "regulation of T-helper 2 type immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002828 ; owl:annotatedTarget "regulation of Th2 immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002829 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002829 ; owl:annotatedTarget "negative regulation of T-helper 2 type immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002829 ; owl:annotatedTarget "negative regulation of Th2 immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22432114" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002830 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002830 ; owl:annotatedTarget "positive regulation of T-helper 2 type immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0002830 ; owl:annotatedTarget "positive regulation of Th2 immune response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22441184" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002831 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002832 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22459582" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002833 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "PMID:22498455" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002886 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002887 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "Reaxys:112064" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002888 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002889 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." . [] obo:RO_0002581 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002479 ; owl:annotatedTarget (obo:BFO_0000051 obo:BFO_0000066 ) . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "2-imino-1-methylimidazolidin-4-one" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002890 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "Creatinine" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002891 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002920 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of a humoral immune response." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "creatinine" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002921 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0002922 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "creatinine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003002 ; owl:annotatedTarget "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003002 ; owl:annotatedTarget "pattern formation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003006 ; owl:annotatedTarget "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0003006 ; owl:annotatedTarget "puberty" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003006 ; owl:annotatedTarget "reproductive developmental process" . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003008 ; owl:annotatedTarget "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "1-Methylglycocyamidine" . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003009 ; owl:annotatedTarget "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003010 ; owl:annotatedTarget "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003012 ; owl:annotatedTarget "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003013 ; owl:annotatedTarget "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:mtg_cardio", "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003014 ; owl:annotatedTarget "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003015 ; owl:annotatedTarget "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_cardio", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003016 ; owl:annotatedTarget "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003044 ; owl:annotatedTarget "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "1-Methylhydantoin-2-imide" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_cardio", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003071 ; owl:annotatedTarget "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0003071 ; owl:annotatedTarget "renal regulation of systemic arterial blood pressure" . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003073 ; owl:annotatedTarget "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003081 ; owl:annotatedTarget "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003091 ; owl:annotatedTarget "Renal process involved in the maintenance of an internal steady state of water in the body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "1-methylglycocyamidine" . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003093 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." . [] oboInOwl:hasDbXref "GOC:mtg_cardio", "GOC:sart", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003094 ; owl:annotatedTarget "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003097 ; owl:annotatedTarget "The directed movement of water (H2O) by the renal system." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "2-Amino-1-methylimidazolin-4-one" . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003104 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-one" . [] oboInOwl:hasDbXref "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003105 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003330 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "Creatine anhydride" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003331 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003332 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003341 ; owl:annotatedTarget "The directed, self-propelled movement of a cilium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "Kreatinin" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0003341 ; owl:annotatedTarget "flagellar movement" . [] oboInOwl:hasDbXref "GOC:ascb_2009", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003341 ; owl:annotatedTarget "cilium beating" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003352 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003352 ; owl:annotatedTarget "regulation of flagellar movement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16737 ; owl:annotatedTarget "creatinina" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003353 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003353 ; owl:annotatedTarget "positive regulation of flagellar movement" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003354 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." . [] oboInOwl:hasDbXref "GOC:pdt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003674 ; owl:annotatedTarget "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." . [] oboInOwl:hasDbXref "GOC:vw", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003824 ; owl:annotatedTarget "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0003824 ; owl:annotatedTarget "enzyme activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-ketoacyl-CoA reductase" . [] a owl:Axiom ; rdfs:label "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-193455" . [] a owl:Axiom ; rdfs:label "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-193508" . [] a owl:Axiom ; rdfs:label "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-389995" . [] a owl:Axiom ; rdfs:label "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-390251" . [] a owl:Axiom ; rdfs:label "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-508369" . [] a owl:Axiom ; rdfs:label "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-6809264" . [] a owl:Axiom ; rdfs:label "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-70837" . [] a owl:Axiom ; rdfs:label "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77254" . [] a owl:Axiom ; rdfs:label "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77283" . [] a owl:Axiom ; rdfs:label "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77303" . [] a owl:Axiom ; rdfs:label "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77312" . [] a owl:Axiom ; rdfs:label "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77323" . [] a owl:Axiom ; rdfs:label "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77331" . [] a owl:Axiom ; rdfs:label "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "Reactome:R-HSA-77342" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" . [] oboInOwl:hasDbXref "PMID:19685079" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "3-oxoacyl-thioester reductase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "L-3-hydroxyacyl CoA dehydrogenase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "L-3-hydroxyacyl coenzyme A dehydrogenase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-hydroxyacyl dehydrogenase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-hydroxyacyl-coenzyme A synthetase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-hydroxyacylcoenzyme A dehydrogenase activity" . [] oboInOwl:hasDbXref "EC:1.1.1.35" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0003857 ; owl:annotatedTarget "beta-keto-reductase activity" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "glycerophosphatase activity" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "phosphomonoesterase activity" . [] a owl:Axiom ; rdfs:label "ALPI dimer hydrolyses phosphate monoesters" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "Reactome:R-HSA-8878787" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "alkaline phenyl phosphatase activity" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "alkaline phosphohydrolase activity" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "alkaline phosphomonoesterase activity" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" . [] oboInOwl:hasDbXref "EC:3.1.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004035 ; owl:annotatedTarget "phosphate-monoester phosphohydrolase (alkaline optimum)" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." . [] a owl:Axiom ; rdfs:label "CPT1A,B transfers PALM to CAR" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "Reactome:R-HSA-200406" . [] a owl:Axiom ; rdfs:label "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "Reactome:R-HSA-200410" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPT" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPT I (outer membrane carnitine palmitoyl transferase)" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPT-A" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPT-B" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPTi" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "CPTo" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "L-carnitine palmitoyltransferase activity" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "acylcarnitine transferase activity" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "carnitine palmitoyltransferase I" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Beilstein:383901" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "carnitine palmitoyltransferase II" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "carnitine palmitoyltransferase activity" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "carnitine palmitoyltransferase-A" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" . [] oboInOwl:hasDbXref "EC:2.3.1.21" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004095 ; owl:annotatedTarget "palmitoylcarnitine transferase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.2", "RHEA:12460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "Catalysis of the reaction: (S)-malate = fumarate + H2O." . [] a owl:Axiom ; rdfs:label "(S)-Malate <=> Fumarate + H2O" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "Reactome:R-HSA-451033" . [] a owl:Axiom ; rdfs:label "Fumarate + H2O <=> (S)-Malate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "Reactome:R-HSA-70982" . [] oboInOwl:hasDbXref "EC:4.2.1.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "(S)-malate hydro-lyase (fumarate-forming)" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "CAS:65-86-1" . [] oboInOwl:hasDbXref "EC:4.2.1.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "(S)-malate hydro-lyase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "L-malate hydro-lyase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004333 ; owl:annotatedTarget "fumarase activity" . [] oboInOwl:hasDbXref "EC:5.4.99.2", "RHEA:22888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." . [] a owl:Axiom ; rdfs:label "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "Reactome:R-HSA-3322971" . [] a owl:Axiom ; rdfs:label "MUT isomerises L-MM-CoA to SUCC-CoA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "Reactome:R-HSA-71010" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "(S)-methylmalonyl-CoA mutase activity" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "methylmalonyl coenzyme A carbonylmutase activity" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "CAS:65-86-1" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "methylmalonyl coenzyme A mutase activity" . [] oboInOwl:hasDbXref "EC:5.4.99.2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004494 ; owl:annotatedTarget "methylmalonyl-CoA CoA-carbonyl mutase activity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004553 ; owl:annotatedTarget "Catalysis of the hydrolysis of any O-glycosyl bond." . [] a owl:Axiom ; rdfs:label "ABHD10 hydrolyses MPAG" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004553 ; owl:annotatedTarget "Reactome:R-HSA-5694563" . [] a owl:Axiom ; rdfs:label "CHIT1 hydrolyses CHIT to 3xADGP" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004553 ; owl:annotatedTarget "Reactome:R-HSA-6786652" . [] a owl:Axiom ; rdfs:label "Bacterial GUSB hydrolyses BDG to BIL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004553 ; owl:annotatedTarget "Reactome:R-HSA-9661820" . [] oboInOwl:hasDbXref "PMID:12527308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004556 ; owl:annotatedTarget "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." . [] oboInOwl:hasDbXref "EC:3.2.1.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0004556 ; owl:annotatedTarget "glycogenase activity" . [] a owl:Axiom ; rdfs:label "Digestion of linear starch (amylose) by extracellular amylase" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004556 ; owl:annotatedTarget "Reactome:R-HSA-188979" . [] a owl:Axiom ; rdfs:label "Digestion of branched starch (amylopectin) by extracellular amylase" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004556 ; owl:annotatedTarget "Reactome:R-HSA-191114" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "CAS:65-86-1" . [] oboInOwl:hasDbXref "EC:3.2.1.23" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." . [] a owl:Axiom ; rdfs:label "Beta-galactosidase hydrolyses GM1 to GM2" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-1605624" . [] a owl:Axiom ; rdfs:label "Beta-galactosidase can also hydrolyse globosides to form cerebrosides" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-1606312" . [] a owl:Axiom ; rdfs:label "GLB1 hydrolyses a glycosaminoglycan" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-1630306" . [] a owl:Axiom ; rdfs:label "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-1793217" . [] a owl:Axiom ; rdfs:label "GLB1 hydrolyses linker chain(2)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-2090079" . [] a owl:Axiom ; rdfs:label "Defective GLB1 does not hydrolyse a glycosaminoglycan" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-2265534" . [] a owl:Axiom ; rdfs:label "Defective GLB1 does not hydrolyse linker chain(2)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "Reactome:R-HSA-9036061" . [] oboInOwl:hasDbXref "EC:3.2.1.23" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004565 ; owl:annotatedTarget "exo-(1->4)-beta-D-galactanase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3", "RHEA:14801" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Drug_Central:3402" . [] a owl:Axiom ; rdfs:label "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "Reactome:R-HSA-70486" . [] a owl:Axiom ; rdfs:label "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "Reactome:R-HSA-71850" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-PGK" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-phosphoglycerate kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-phosphoglycerate phosphokinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-phosphoglyceric acid kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-phosphoglyceric acid phosphokinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "3-phosphoglyceric kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Gmelin:101990" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "PGK" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "glycerate 3-phosphate kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "glycerophosphate kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "phosphoglyceric acid kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "phosphoglyceric kinase activity" . [] oboInOwl:hasDbXref "EC:2.7.2.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004618 ; owl:annotatedTarget "phosphoglycerokinase activity" . [] oboInOwl:hasDbXref "RHEA:15901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004619 ; owl:annotatedTarget "Catalysis of the reaction: 2-phosphoglycerate = 3-phosphoglycerate." . [] a owl:Axiom ; rdfs:label "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004619 ; owl:annotatedTarget "Reactome:R-HSA-71445" . [] a owl:Axiom ; rdfs:label "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004619 ; owl:annotatedTarget "Reactome:R-HSA-71654" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:11059538" . [] oboInOwl:hasDbXref "EC:4.2.1.11", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." . [] a owl:Axiom ; rdfs:label "Enolase dimers (ENO1,2,3) convert PEP to 2PG" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "Reactome:R-HSA-70494" . [] a owl:Axiom ; rdfs:label "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "Reactome:R-HSA-71660" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "nervous-system specific enolase" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "14-3-2-protein" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "2-phospho-D-glycerate hydro-lyase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "2-phosphoglycerate dehydratase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "2-phosphoglycerate enolase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "2-phosphoglyceric dehydratase activity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22019295" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "enolase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "gamma-enolase activity" . [] oboInOwl:hasDbXref "EC:4.2.1.11" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004634 ; owl:annotatedTarget "phosphoenolpyruvate hydratase activity" . [] oboInOwl:hasDbXref "EC:6.4.1.3" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004658 ; owl:annotatedTarget "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." . [] a owl:Axiom ; rdfs:label "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004658 ; owl:annotatedTarget "Reactome:R-HSA-71031" . [] oboInOwl:hasDbXref "EC:6.4.1.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004658 ; owl:annotatedTarget "PCCase activity" . [] oboInOwl:hasDbXref "EC:6.4.1.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004658 ; owl:annotatedTarget "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" . [] oboInOwl:hasDbXref "EC:6.4.1.3" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004658 ; owl:annotatedTarget "propionyl coenzyme A carboxylase activity" . [] oboInOwl:hasDbXref "EC:6.4.1.1", "RHEA:20844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004736 ; owl:annotatedTarget "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate." . [] a owl:Axiom ; rdfs:label "PC catalyzes the carboxylation of PYR to form OA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004736 ; owl:annotatedTarget "Reactome:R-HSA-70501" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22285839" . [] oboInOwl:hasDbXref "EC:6.4.1.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004736 ; owl:annotatedTarget "pyruvate:carbon-dioxide ligase (ADP-forming)" . [] oboInOwl:hasDbXref "EC:6.4.1.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0004736 ; owl:annotatedTarget "pyruvic carboxylase activity" . [] oboInOwl:hasDbXref "GOC:go_curators", "Wikipedia:Transmembrane_receptor" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004888 ; owl:annotatedTarget "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0004888 ; owl:annotatedTarget "transmembrane receptor activity" . [] a owl:Axiom ; rdfs:label "Sphingomyelinase is activated by the NGF:p75NTR complex" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004888 ; owl:annotatedTarget "Reactome:R-HSA-193672" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0004888 ; owl:annotatedTarget "transmembrane signalling receptor activity" . [] oboInOwl:hasDbXref "GOC:bf", "Wikipedia:GPCR", "http://www.iuphar-db.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0004930 ; owl:annotatedTarget "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." . [] a owl:Axiom ; rdfs:label "Thrombin-activated PARs activate G12/13" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004930 ; owl:annotatedTarget "Reactome:R-HSA-114552" . [] a owl:Axiom ; rdfs:label "Thrombin-activated PARs activate Gq" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004930 ; owl:annotatedTarget "Reactome:R-HSA-114558" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22307261" . [] a owl:Axiom ; rdfs:label "The high affinity receptor complex binds to G-protein" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0004930 ; owl:annotatedTarget "Reactome:R-HSA-167408" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0004930 ; owl:annotatedTarget "receptor activity, G-protein coupled" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dgf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005215 ; owl:annotatedTarget "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." . [] a owl:Axiom ; rdfs:label "Virion-associated M2 protein mediated ion infusion" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0005215 ; owl:annotatedTarget "Reactome:R-HSA-168313" . [] a owl:Axiom ; rdfs:label "SMAD7:SMURF1 complex is exported to the cytosol" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0005215 ; owl:annotatedTarget "Reactome:R-HSA-178215" . [] oboInOwl:hasDbXref "GOC:pdt", "NIF_Subcellular:sao1337158144" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005575 ; owl:annotatedTarget "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." . [] oboInOwl:hasDbXref "NIF_Subcellular:nlx_subcell_100315" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0005575 ; owl:annotatedTarget "subcellular entity" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005576 ; owl:annotatedTarget "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005577 ; owl:annotatedTarget "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22371390" . [] oboInOwl:hasDbXref "GOC:dos", "GOC:mah", "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005581 ; owl:annotatedTarget "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0721639976", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005583 ; owl:annotatedTarget "Any triple helical collagen trimer that forms fibrils." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:sl", "ISBN:0721639976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005584 ; owl:annotatedTarget "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." . [] oboInOwl:hasDbXref "ISBN:0721639976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005585 ; owl:annotatedTarget "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." . [] oboInOwl:hasDbXref "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005587 ; owl:annotatedTarget "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22634191" . [] oboInOwl:hasDbXref "ISBN:0198547684", "PMID:22505934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005604 ; owl:annotatedTarget "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005615 ; owl:annotatedTarget "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005622 ; owl:annotatedTarget "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0005622 ; owl:annotatedTarget "nucleocytoplasm" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0005622 ; owl:annotatedTarget "protoplast" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005623 ; owl:annotatedTarget "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005634 ; owl:annotatedTarget "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." . [] oboInOwl:hasDbXref "GOC:al", "GOC:mah", "GOC:vw", "PMID:15030757" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0005634 ; owl:annotatedTarget "horsetail nucleus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22707164" . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005635 ; owl:annotatedTarget "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005694 ; owl:annotatedTarget "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005730 ; owl:annotatedTarget "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005737 ; owl:annotatedTarget "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." . [] oboInOwl:hasDbXref "GOC:giardia", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005739 ; owl:annotatedTarget "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:pz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005740 ; owl:annotatedTarget "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005743 ; owl:annotatedTarget "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:ecd", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005746 ; owl:annotatedTarget "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:22863860" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005753 ; owl:annotatedTarget "A proton-transporting ATP synthase complex found in the mitochondrial membrane." . [] oboInOwl:hasDbXref "GOC:as", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005759 ; owl:annotatedTarget "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "PMID:7264771" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005761 ; owl:annotatedTarget "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005764 ; owl:annotatedTarget "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005766 ; owl:annotatedTarget "A lysosome before it has fused with a vesicle or vacuole." . [] oboInOwl:hasDbXref "GOC:mtg_sensu", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005773 ; owl:annotatedTarget "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Reaxys:383901" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005775 ; owl:annotatedTarget "The volume enclosed within the vacuolar membrane." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005840 ; owl:annotatedTarget "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1139385046" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0005840 ; owl:annotatedTarget "free ribosome" . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1291545653" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0005840 ; owl:annotatedTarget "membrane bound ribosome" . [] oboInOwl:hasDbXref "GOC:mah", "PMID:16959967", "PMID:27419875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005856 ; owl:annotatedTarget "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." . [] oboInOwl:hasDbXref "ISBN:0198506732", "http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005882 ; owl:annotatedTarget "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732", "PMID:10666339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005884 ; owl:annotatedTarget "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid" . [] oboInOwl:hasDbXref "ISBN:0716731363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005886 ; owl:annotatedTarget "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao6433132645" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0005886 ; owl:annotatedTarget "cellular membrane" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0005886 ; owl:annotatedTarget "plasma membrane lipid bilayer" . [] oboInOwl:hasDbXref "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005902 ; owl:annotatedTarget "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao671419673" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0005902 ; owl:annotatedTarget "microvilli" . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "GOC:dgh", "GOC:hb", "GOC:mah", "PMID:21422226", "PMID:28096264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005911 ; owl:annotatedTarget "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1395777368" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0005911 ; owl:annotatedTarget "intercellular junction" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:curators", "GOC:kmv", "GOC:vw", "ISBN:0198547684", "PMID:16824949", "PMID:17009929", "PMID:20144998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005929 ; owl:annotatedTarget "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "OROTIC ACID" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005938 ; owl:annotatedTarget "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005975 ; owl:annotatedTarget "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005976 ; owl:annotatedTarget "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005977 ; owl:annotatedTarget "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005978 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Orotic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005979 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005980 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0005980 ; owl:annotatedTarget "glycogenolysis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Orotsaeure" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005981 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0005981 ; owl:annotatedTarget "regulation of glycogenolysis" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0005996 ; owl:annotatedTarget "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006000 ; owl:annotatedTarget "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006006 ; owl:annotatedTarget "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006006 ; owl:annotatedTarget "cellular glucose metabolic process" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006012 ; owl:annotatedTarget "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16742 ; owl:annotatedTarget "Uracil-6-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006022 ; owl:annotatedTarget "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006023 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." . [] oboInOwl:hasDbXref "ISBN:0192800981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006024 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006066 ; owl:annotatedTarget "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006081 ; owl:annotatedTarget "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006082 ; owl:annotatedTarget "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006089 ; owl:annotatedTarget "The chemical reactions and pathways involving lactate, the anion of lactic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006090 ; owl:annotatedTarget "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006091 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006091 ; owl:annotatedTarget "intermediary metabolism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_167559 ; owl:annotatedTarget "glycans" . [] oboInOwl:hasDbXref "MetaCyc:GLUCONEO-PWY" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006094 ; owl:annotatedTarget "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:dph", "ISBN:0201090910", "ISBN:0716720094", "ISBN:0879010479", "Wikipedia:Glycolysis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006096 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006096 ; owl:annotatedTarget "glycolysis" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006109 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006110 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glycolysis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006111 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006112 ; owl:annotatedTarget "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006139 ; owl:annotatedTarget "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006139 ; owl:annotatedTarget "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006141 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006141 ; owl:annotatedTarget "regulation of purine base metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006142 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006142 ; owl:annotatedTarget "regulation of pyrimidine base metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006144 ; owl:annotatedTarget "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006144 ; owl:annotatedTarget "purine base metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006206 ; owl:annotatedTarget "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006206 ; owl:annotatedTarget "pyrimidine base metabolic process" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006259 ; owl:annotatedTarget "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." . [] oboInOwl:hasDbXref "PMID:11563486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006281 ; owl:annotatedTarget "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "Beilstein:125513" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006282 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of DNA repair." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006310 ; owl:annotatedTarget "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." . [] oboInOwl:hasDbXref "PMID:20404130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006325 ; owl:annotatedTarget "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006325 ; owl:annotatedTarget "chromatin organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006325 ; owl:annotatedTarget "establishment of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006325 ; owl:annotatedTarget "establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:jid", "GOC:vw", "PMID:12042764", "PMID:12697820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006338 ; owl:annotatedTarget "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "CAS:61-54-1" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006412 ; owl:annotatedTarget "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." . [] oboInOwl:hasDbXref "GOC:ems" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006414 ; owl:annotatedTarget "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "CAS:61-54-1" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006417 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006448 ; owl:annotatedTarget "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006486 ; owl:annotatedTarget "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006486 ; owl:annotatedTarget "protein amino acid glycosylation" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "CAS:61-54-1" . [] oboInOwl:hasDbXref "GOC:pr", "RESID:AA0151", "RESID:AA0156", "RESID:AA0327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006487 ; owl:annotatedTarget "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006487 ; owl:annotatedTarget "protein amino acid N-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:pr", "ISBN:0879695595", "RESID:AA0153", "RESID:AA0154", "RESID:AA0155", "RESID:AA0157", "RESID:AA0212" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006493 ; owl:annotatedTarget "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006493 ; owl:annotatedTarget "protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006508 ; owl:annotatedTarget "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0006508 ; owl:annotatedTarget "ATP-dependent proteolysis" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006518 ; owl:annotatedTarget "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006520 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "Gmelin:603448" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006521 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006525 ; owl:annotatedTarget "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006534 ; owl:annotatedTarget "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006541 ; owl:annotatedTarget "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006544 ; owl:annotatedTarget "The chemical reactions and pathways involving glycine, aminoethanoic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006547 ; owl:annotatedTarget "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006549 ; owl:annotatedTarget "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "PMID:16126914" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006551 ; owl:annotatedTarget "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006553 ; owl:annotatedTarget "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006555 ; owl:annotatedTarget "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." . [] oboInOwl:hasDbXref "GOC:jsg", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006558 ; owl:annotatedTarget "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006560 ; owl:annotatedTarget "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jsg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006563 ; owl:annotatedTarget "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006566 ; owl:annotatedTarget "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006568 ; owl:annotatedTarget "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006570 ; owl:annotatedTarget "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006573 ; owl:annotatedTarget "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006575 ; owl:annotatedTarget "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006575 ; owl:annotatedTarget "cellular modified amino acid metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006575 ; owl:annotatedTarget "modified amino acid metabolic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006575 ; owl:annotatedTarget "modified amino acid metabolism" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0395825172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006576 ; owl:annotatedTarget "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006577 ; owl:annotatedTarget "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006582 ; owl:annotatedTarget "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006586 ; owl:annotatedTarget "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0716720094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006590 ; owl:annotatedTarget "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006591 ; owl:annotatedTarget "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "PMID:24345948" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006600 ; owl:annotatedTarget "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006624 ; owl:annotatedTarget "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." . [] oboInOwl:hasDbXref "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006629 ; owl:annotatedTarget "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006631 ; owl:annotatedTarget "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006643 ; owl:annotatedTarget "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "PMID:24558969" . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006664 ; owl:annotatedTarget "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006665 ; owl:annotatedTarget "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006672 ; owl:annotatedTarget "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006687 ; owl:annotatedTarget "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." . [] oboInOwl:hasDbXref "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006690 ; owl:annotatedTarget "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006692 ; owl:annotatedTarget "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006693 ; owl:annotatedTarget "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006694 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006699 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006704 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "Reaxys:125513" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006705 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006720 ; owl:annotatedTarget "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006721 ; owl:annotatedTarget "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006725 ; owl:annotatedTarget "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006766 ; owl:annotatedTarget "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006767 ; owl:annotatedTarget "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006775 ; owl:annotatedTarget "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." . [] oboInOwl:hasDbXref "GOC:jl", "http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006776 ; owl:annotatedTarget "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732", "Wikipedia:Porphyrin#Natural_formation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006778 ; owl:annotatedTarget "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732", "Wikipedia:Porphyrin#Natural_formation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006779 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "2-(1H-indol-3-yl)ethanamine" . [] oboInOwl:hasDbXref "GOC:jl", "PMID:11788607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006783 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006790 ; owl:annotatedTarget "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006793 ; owl:annotatedTarget "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006796 ; owl:annotatedTarget "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006801 ; owl:annotatedTarget "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006807 ; owl:annotatedTarget "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006810 ; owl:annotatedTarget "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006811 ; owl:annotatedTarget "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006833 ; owl:annotatedTarget "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006835 ; owl:annotatedTarget "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "Tryptamine" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006836 ; owl:annotatedTarget "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006837 ; owl:annotatedTarget "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006858 ; owl:annotatedTarget "The transport of substances that occurs outside cells." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "1H-indole-3-ethanamine" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006860 ; owl:annotatedTarget "The directed extracellular movement of amino acids." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006865 ; owl:annotatedTarget "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006869 ; owl:annotatedTarget "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006873 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:ceb", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006874 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006886 ; owl:annotatedTarget "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "2-(1H-INDOL-3-YL)ETHANAMINE" . [] oboInOwl:hasDbXref "GOC:al" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006886 ; owl:annotatedTarget "copper-induced intracellular protein transport" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0716731363", "PMID:22323285" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006887 ; owl:annotatedTarget "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732", "ISBN:0716731363", "Wikipedia:Endocytosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006897 ; owl:annotatedTarget "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006900 ; owl:annotatedTarget "The evagination of a membrane, resulting in formation of a vesicle." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006900 ; owl:annotatedTarget "single organism membrane budding" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "2-(3-indolyl)ethylamine" . [] oboInOwl:hasDbXref "GOC:mah", "PMID:17335816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006903 ; owl:annotatedTarget "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006906 ; owl:annotatedTarget "Fusion of the membrane of a transport vesicle with its target membrane." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006909 ; owl:annotatedTarget "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:dhl", "GOC:ecd", "GOC:go_curators", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0198506732", "PMID:18846107", "PMID:21494263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006915 ; owl:annotatedTarget "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006915 ; owl:annotatedTarget "apoptotic cell death" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0006915 ; owl:annotatedTarget "apoptotic program" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16765 ; owl:annotatedTarget "3-(2-Aminoethyl)indole" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006921 ; owl:annotatedTarget "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006935 ; owl:annotatedTarget "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:mtg_muscle", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006936 ; owl:annotatedTarget "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006937 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of muscle contraction." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006939 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006940 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006941 ; owl:annotatedTarget "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006942 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of striated muscle contraction." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006950 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006952 ; owl:annotatedTarget "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." . [] oboInOwl:hasDbXref "GO_REF:0000022", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006954 ; owl:annotatedTarget "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16782 ; owl:annotatedTarget "Beilstein:5257108" . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006955 ; owl:annotatedTarget "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006956 ; owl:annotatedTarget "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006956 ; owl:annotatedTarget "complement cascade" . [] oboInOwl:hasDbXref "GOC:hb", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006959 ; owl:annotatedTarget "An immune response mediated through a body fluid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006974 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006996 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0006996 ; owl:annotatedTarget "single organism organelle organization" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006996 ; owl:annotatedTarget "organelle organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0006997 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16782 ; owl:annotatedTarget "Reaxys:5257108" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006997 ; owl:annotatedTarget "nuclear organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0006997 ; owl:annotatedTarget "nucleus organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah", "GOC:sgd_curators", "PMID:9786946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007005 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007005 ; owl:annotatedTarget "mitochondria organization" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007005 ; owl:annotatedTarget "mitochondrion organisation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16782 ; owl:annotatedTarget "(2S)-2-hydroxypentanedioate" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007006 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007006 ; owl:annotatedTarget "mitochondrial membrane organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007009 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007009 ; owl:annotatedTarget "plasma membrane organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007010 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007010 ; owl:annotatedTarget "cytoskeletal organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007010 ; owl:annotatedTarget "cytoskeleton organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007017 ; owl:annotatedTarget "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." . [] oboInOwl:hasDbXref "GOC:cjm", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007018 ; owl:annotatedTarget "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16782 ; owl:annotatedTarget "(S)-2-hydroxyglutarate" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007036 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:mtg_cell_cycle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007049 ; owl:annotatedTarget "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah", "GOC:mtg_cell_cycle", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007059 ; owl:annotatedTarget "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007076 ; owl:annotatedTarget "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007088 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mitosis." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:dos", "GOC:expert_vm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007113 ; owl:annotatedTarget "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007135 ; owl:annotatedTarget "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007140 ; owl:annotatedTarget "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007142 ; owl:annotatedTarget "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ems", "GOC:mah", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007143 ; owl:annotatedTarget "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002492 ; owl:annotatedTarget "Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007147 ; owl:annotatedTarget "The cell cycle process in which the second meiotic division occurs in the female germline." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007154 ; owl:annotatedTarget "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." . [] oboInOwl:hasDbXref "GOC:hb", "GOC:pf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007155 ; owl:annotatedTarget "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007159 ; owl:annotatedTarget "The attachment of a leukocyte to another cell via adhesion molecules." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007162 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:mtg_signaling_feb11" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007165 ; owl:annotatedTarget "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007165 ; owl:annotatedTarget "signalling pathway" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:mah", "GOC:pr", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007166 ; owl:annotatedTarget "The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007166 ; owl:annotatedTarget "cell surface receptor linked signaling pathway" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007166 ; owl:annotatedTarget "cell surface receptor linked signalling pathway" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:mah", "PMID:16902576", "PMID:24568158", "Wikipedia:G_protein-coupled_receptor" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007186 ; owl:annotatedTarget "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "Beilstein:3664503" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007186 ; owl:annotatedTarget "G-protein coupled receptor protein signaling pathway" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0007186 ; owl:annotatedTarget "G-protein coupled receptor signaling pathway via GPCR dimer" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0007186 ; owl:annotatedTarget "dimeric G-protein coupled receptor signalling pathway" . [] oboInOwl:hasDbXref "GOC:dos", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007267 ; owl:annotatedTarget "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." . [] oboInOwl:hasDbXref "GOC:jl", "MeSH:D009435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007268 ; owl:annotatedTarget "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0007268 ; owl:annotatedTarget "neurotransmission" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007269 ; owl:annotatedTarget "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." . [] oboInOwl:hasDbXref "GOC:dos", "Wikipedia:Cholinergic" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007271 ; owl:annotatedTarget "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "CAS:64-15-3" . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007272 ; owl:annotatedTarget "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:jl", "MeSH:D009435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007274 ; owl:annotatedTarget "The process of synaptic transmission from a neuron to a muscle, across a synapse." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ems", "GOC:isa_complete", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007275 ; owl:annotatedTarget "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." . [] oboInOwl:hasDbXref "GOC:ems", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007276 ; owl:annotatedTarget "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007281 ; owl:annotatedTarget "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." . [] oboInOwl:hasDbXref "GOC:jid", "ISBN:9780878933846", "PMID:28073824", "PMID:30990821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007283 ; owl:annotatedTarget "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." . [] oboInOwl:hasSynonymType go:systematic_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007283 ; owl:annotatedTarget "generation of spermatozoa" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "Gmelin:602479" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007286 ; owl:annotatedTarget "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:cilia", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007288 ; owl:annotatedTarget "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007289 ; owl:annotatedTarget "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." . [] oboInOwl:hasDbXref "GOC:dph", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007292 ; owl:annotatedTarget "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." . [] oboInOwl:hasDbXref "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007320 ; owl:annotatedTarget "The introduction of semen or sperm into the genital tract of a female." . [] oboInOwl:hasDbXref "GOC:ems", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007338 ; owl:annotatedTarget "The union of male and female gametes to form a zygote." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:11913971" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007346 ; owl:annotatedTarget "Any process that modulates the rate or extent of progress through the mitotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007346 ; owl:annotatedTarget "regulation of progression through mitotic cell cycle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:15612731" . [] oboInOwl:hasDbXref "GOC:curators", "ISBN:9780878933846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007369 ; owl:annotatedTarget "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete", "ISBN:0521436125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007389 ; owl:annotatedTarget "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007398 ; owl:annotatedTarget "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007399 ; owl:annotatedTarget "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:jid", "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007417 ; owl:annotatedTarget "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." . [] oboInOwl:hasDbXref "GOC:go_curators", "UBERON:0000010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007422 ; owl:annotatedTarget "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007492 ; owl:annotatedTarget "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007498 ; owl:annotatedTarget "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007548 ; owl:annotatedTarget "The establishment of the sex of an organism by physical differentiation." . [] oboInOwl:hasDbXref "ISBN:0192800825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007565 ; owl:annotatedTarget "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007567 ; owl:annotatedTarget "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007585 ; owl:annotatedTarget "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." . [] oboInOwl:hasDbXref "GOC:isa_complete", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007586 ; owl:annotatedTarget "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." . [] oboInOwl:hasDbXref "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007588 ; owl:annotatedTarget "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007589 ; owl:annotatedTarget "The controlled release of a fluid by a cell or tissue in an animal." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:19376872" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007595 ; owl:annotatedTarget "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0007595 ; owl:annotatedTarget "milk secretion" . [] oboInOwl:hasDbXref "ISBN:0198506732", "http://www.graylab.ac.uk/omd/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007596 ; owl:annotatedTarget "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "GOC:pde" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007597 ; owl:annotatedTarget "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "GOC:pde" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007598 ; owl:annotatedTarget "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007599 ; owl:annotatedTarget "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007600 ; owl:annotatedTarget "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:21184277" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007601 ; owl:annotatedTarget "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007605 ; owl:annotatedTarget "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007606 ; owl:annotatedTarget "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007608 ; owl:annotatedTarget "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." . [] oboInOwl:hasDbXref "GOC:ems", "GOC:jl", "ISBN:0395448956", "PMID:20160973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007610 ; owl:annotatedTarget "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." . [] oboInOwl:hasDbXref "GOC:jid", "PMID:8938125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007611 ; owl:annotatedTarget "The acquisition and processing of information and/or the storage and retrieval of this information over time." . [] oboInOwl:hasDbXref "GOC:curators", "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007613 ; owl:annotatedTarget "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007617 ; owl:annotatedTarget "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007620 ; owl:annotatedTarget "The act of sexual union between male and female, involving the transfer of sperm." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007622 ; owl:annotatedTarget "The specific behavior of an organism that recur with measured regularity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:21196226" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007623 ; owl:annotatedTarget "Any biological process in an organism that recurs with a regularity of approximately 24 hours." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007626 ; owl:annotatedTarget "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0007631 ; owl:annotatedTarget "Behavior associated with the intake of food." . [] oboInOwl:hasDbXref "GOC:mtg_heart", "ISBN:0192800825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008015 ; owl:annotatedTarget "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008016 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:21791173" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008104 ; owl:annotatedTarget "Any process in which a protein is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0008104 ; owl:annotatedTarget "cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0008104 ; owl:annotatedTarget "protein localisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0008104 ; owl:annotatedTarget "channel localizer activity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0008104 ; owl:annotatedTarget "asymmetric protein localisation" . [] oboInOwl:hasDbXref "GOC:pdt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008150 ; owl:annotatedTarget "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008152 ; owl:annotatedTarget "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008202 ; owl:annotatedTarget "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008203 ; owl:annotatedTarget "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008206 ; owl:annotatedTarget "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "PMID:24828042" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008211 ; owl:annotatedTarget "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008212 ; owl:annotatedTarget "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_cardio", "ISBN:0721643949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008217 ; owl:annotatedTarget "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008219 ; owl:annotatedTarget "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "Reaxys:3664503" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008277 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008283 ; owl:annotatedTarget "The multiplication or reproduction of cells, resulting in the expansion of a cell population." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008284 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of cell proliferation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "2-oxopentanedioate" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008285 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of cell proliferation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008348 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "2-ketoglutarate" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0878932437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008366 ; owl:annotatedTarget "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." . [] a owl:Axiom ; rdfs:label "MLCL is acylated to CL by HADH (IM)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-1482775" . [] a owl:Axiom ; rdfs:label "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-1482781" . [] a owl:Axiom ; rdfs:label "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-1482850" . [] a owl:Axiom ; rdfs:label "MLCL is acylated to CL by LCLAT1 (ER)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-1482861" . [] a owl:Axiom ; rdfs:label "DLCL is acylated to MLCL by LCLAT1 (ER)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-1482867" . [] a owl:Axiom ; rdfs:label "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-162683" . [] a owl:Axiom ; rdfs:label "PORCN palmitoleoylates N-glycosyl WNTs" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-3238694" . [] a owl:Axiom ; rdfs:label "Ghrelin O-acyltransferase decanoylates Proghrelin" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-422017" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "2-oxoglutarate" . [] a owl:Axiom ; rdfs:label "Ghrelin O-acyltransferase octanoylates Proghrelin" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-422104" . [] a owl:Axiom ; rdfs:label "HHAT palmitoylates Hh N-terminal fragment" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-5358343" . [] a owl:Axiom ; rdfs:label "HHAT G287V doesn't palmitoylate Hh-Np" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008374 ; owl:annotatedTarget "Reactome:R-HSA-5483229" . [] oboInOwl:hasDbXref "EC:1.8.3.1", "RHEA:24600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008482 ; owl:annotatedTarget "Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." . [] a owl:Axiom ; rdfs:label "Sulfite is oxidized to sulfate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008482 ; owl:annotatedTarget "Reactome:R-HSA-1614544" . [] oboInOwl:hasDbXref "EC:1.8.3.1" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0008482 ; owl:annotatedTarget "sulfite:oxygen oxidoreductase activity" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008483 ; owl:annotatedTarget "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." . [] a owl:Axiom ; rdfs:label "Transamination of MOB to methionine" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008483 ; owl:annotatedTarget "Reactome:R-HSA-1237102" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008514 ; owl:annotatedTarget "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "2-oxopentanedioic acid, ion(2-)" . [] a owl:Axiom ; rdfs:label "Growing HA is extruded from the cell by ABCC5" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008514 ; owl:annotatedTarget "Reactome:R-HSA-2142859" . [] a owl:Axiom ; rdfs:label "OAT1-3 transport organic anions with antiport of dicarboxylic acids" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008514 ; owl:annotatedTarget "Reactome:R-HSA-561041" . [] a owl:Axiom ; rdfs:label "SLC22A8 transports Cipro into renal cell" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0008514 ; owl:annotatedTarget "Reactome:R-HSA-9794830" . [] oboInOwl:hasDbXref "GOC:go_curators", "UBERON:0001003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008544 ; owl:annotatedTarget "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0008544 ; owl:annotatedTarget "hypodermis development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008610 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0008610 ; owl:annotatedTarget "lipogenesis" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008643 ; owl:annotatedTarget "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0008645 ; owl:annotatedTarget "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009056 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16810 ; owl:annotatedTarget "alpha-ketoglutarate" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009057 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:mtg_chebi_dec09" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0009057 ; owl:annotatedTarget "biopolymer catabolic process" . [] oboInOwl:hasDbXref "GOC:curators", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009058 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009059 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:mtg_chebi_dec09" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0009059 ; owl:annotatedTarget "biopolymer biosynthetic process" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009064 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009066 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009069 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009072 ; owl:annotatedTarget "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009081 ; owl:annotatedTarget "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0009081 ; owl:annotatedTarget "branched chain family amino acid metabolism" . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009100 ; owl:annotatedTarget "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009101 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." . [] oboInOwl:hasDbXref "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009112 ; owl:annotatedTarget "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009235 ; owl:annotatedTarget "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009250 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009251 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." . [] oboInOwl:hasDbXref "GOC:bm", "GOC:ma", "ISBN:3540076689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009295 ; owl:annotatedTarget "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009306 ; owl:annotatedTarget "The controlled release of proteins from a cell." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009308 ; owl:annotatedTarget "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." . [] oboInOwl:hasDbXref "GOC:jl", "Wikipedia:Electromagnetic_radiation" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009314 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009416 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009437 ; owl:annotatedTarget "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009438 ; owl:annotatedTarget "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." . [] oboInOwl:hasDbXref "GOC:tb", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009566 ; owl:annotatedTarget "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009581 ; owl:annotatedTarget "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009582 ; owl:annotatedTarget "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009583 ; owl:annotatedTarget "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009584 ; owl:annotatedTarget "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009593 ; owl:annotatedTarget "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009605 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009607 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009611 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009612 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009615 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009617 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." . [] oboInOwl:hasDbXref "GOC:hb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009628 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." . [] oboInOwl:hasDbXref "GOC:lr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009636 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0521436125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009653 ; owl:annotatedTarget "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009790 ; owl:annotatedTarget "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009791 ; owl:annotatedTarget "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009792 ; owl:annotatedTarget "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:go_curators", "ISBN:0471245208", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009887 ; owl:annotatedTarget "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." . [] oboInOwl:hasDbXref "ISBN:0471245208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009888 ; owl:annotatedTarget "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009889 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009890 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009891 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009892 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009893 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009894 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009895 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009896 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:mtg_sensu", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009913 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0009913 ; owl:annotatedTarget "hypodermal cell differentiation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Beilstein:636185" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009914 ; owl:annotatedTarget "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:sm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009966 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of signal transduction." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0009966 ; owl:annotatedTarget "regulation of signalling pathway" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "CAS:59-51-8" . [] oboInOwl:hasDbXref "GOC:sm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009967 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of signal transduction." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0009967 ; owl:annotatedTarget "positive regulation of signalling pathway" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "CAS:59-51-8" . [] oboInOwl:hasDbXref "GOC:sm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009968 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0009968 ; owl:annotatedTarget "negative regulation of signalling pathway" . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009987 ; owl:annotatedTarget "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0009991 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010001 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "CAS:59-51-8" . [] oboInOwl:hasDbXref "PMID:10072401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010032 ; owl:annotatedTarget "Compaction of chromatin structure prior to meiosis in eukaryotic cells." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010032 ; owl:annotatedTarget "chromosome condensation involved in meiotic cell cycle" . [] oboInOwl:hasDbXref "GOC:sm", "PMID:23356676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010033 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:sm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010256 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010256 ; owl:annotatedTarget "endomembrane system organisation" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010324 ; owl:annotatedTarget "The infolding of a membrane." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010463 ; owl:annotatedTarget "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Gmelin:3117" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010464 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." . [] oboInOwl:hasDbXref "GOC:txnOH-2018", "PMID:25934543", "PMID:31580950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010467 ; owl:annotatedTarget "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." . [] oboInOwl:hasDbXref "GOC:txnOH-2018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010468 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "PMID:16702333" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0010468 ; owl:annotatedTarget "gene regulation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010469 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010470 ; owl:annotatedTarget "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010543 ; owl:annotatedTarget "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "PMID:2543976" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010544 ; owl:annotatedTarget "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Reaxys:636185" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010556 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010557 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "UM-BBD_compID:c0094" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010558 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010559 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Methionine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010560 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "methionine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010561 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010562 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "methionine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010563 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010564 ; owl:annotatedTarget "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "2-Amino-4-(methylthio)butyric acid" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010565 ; owl:annotatedTarget "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "2-amino-4-(methylsulfanyl)butanoic acid" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010567 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010572 ; owl:annotatedTarget "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "2-amino-4-(methylthio)butanoic acid" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010604 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010605 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010608 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." . [] oboInOwl:hasDbXref "KEGG_DRUG" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "DL-Methionine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010623 ; owl:annotatedTarget "The activation of endogenous cellular processes that result in the death of a cell as part of its development." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Hmet" . [] oboInOwl:hasDbXref "GOC:txnOH-2018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010628 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." . [] oboInOwl:hasDbXref "GOC:txnOH-2018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010629 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "M" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010638 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010638 ; owl:annotatedTarget "positive regulation of organelle organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0010638 ; owl:annotatedTarget "positive regulation of organelle organization and biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Met" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010639 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010639 ; owl:annotatedTarget "negative regulation of organelle organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0010639 ; owl:annotatedTarget "negative regulation of organelle organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010646 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Methionin" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010647 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." . [] oboInOwl:hasDbXref "KEGG_DRUG" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "Racemethionine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010648 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010692 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "alpha-amino-gamma-methylmercaptobutyric acid" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010693 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010694 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16811 ; owl:annotatedTarget "metionina" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010700 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010701 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010720 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010721 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010817 ; owl:annotatedTarget "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010821 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010821 ; owl:annotatedTarget "regulation of mitochondrion organisation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010822 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010822 ; owl:annotatedTarget "positive regulation of mitochondrion organisation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010823 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010823 ; owl:annotatedTarget "negative regulation of mitochondrion organisation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Beilstein:1721903" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010827 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010828 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "CAS:608-66-2" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010829 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010876 ; owl:annotatedTarget "Any process in which a lipid is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010876 ; owl:annotatedTarget "lipid localisation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "CAS:608-66-2" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jp", "GOC:tb", "PMID:8830768" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010892 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010893 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "CAS:608-66-2" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010894 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Gmelin:83163" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010906 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010906 ; owl:annotatedTarget "regulation of glucose metabolism" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010907 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010907 ; owl:annotatedTarget "positive regulation of glucose metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:16664750" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010911 ; owl:annotatedTarget "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010912 ; owl:annotatedTarget "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010921 ; owl:annotatedTarget "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010922 ; owl:annotatedTarget "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010923 ; owl:annotatedTarget "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010927 ; owl:annotatedTarget "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:21501963" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010948 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010954 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010954 ; owl:annotatedTarget "positive regulation of protein maturation by peptide bond cleavage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:22155165" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010955 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010955 ; owl:annotatedTarget "negative regulation of protein maturation by peptide bond cleavage" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010960 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:22628202" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010962 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0010970 ; owl:annotatedTarget "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0010970 ; owl:annotatedTarget "establishment of localization by movement along microtubule" . [] oboInOwl:hasDbXref "GOC:lr", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0012501 ; owl:annotatedTarget "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." . [] oboInOwl:hasDbXref "GOC:lh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0012505 ; owl:annotatedTarget "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:22654107" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:vesicle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0012506 ; owl:annotatedTarget "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014003 ; owl:annotatedTarget "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:23830453" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014013 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014014 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014015 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." . [] oboInOwl:hasDbXref "GOC:ef", "ISBN:0878932585", "PMID:15327780" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014020 ; owl:annotatedTarget "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0014020 ; owl:annotatedTarget "primary neural tube morphogenesis" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014037 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Reaxys:1721903" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014038 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Galactitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014039 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014040 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014044 ; owl:annotatedTarget "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014046 ; owl:annotatedTarget "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "galactitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014047 ; owl:annotatedTarget "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014048 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "meso-galactitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014049 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014050 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014051 ; owl:annotatedTarget "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014052 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "D-Dulcitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014053 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014054 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "D-galactitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014055 ; owl:annotatedTarget "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014056 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Dulcitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014057 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Dulcose" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014058 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014059 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Euonymit" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014060 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014061 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "L-galactitol" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014062 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0014062 ; owl:annotatedTarget "regulation of serotonin release" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Melampyrin" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014063 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0014063 ; owl:annotatedTarget "positive regulation of serotonin release" . [] oboInOwl:hasDbXref "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014064 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16813 ; owl:annotatedTarget "Melampyrit" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0014064 ; owl:annotatedTarget "positive regulation of serotonin release" . [] oboInOwl:hasDbXref "GOC:ef", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014819 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." . [] oboInOwl:hasDbXref "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014821 ; owl:annotatedTarget "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." . [] oboInOwl:hasDbXref "GOC:mtg_muscle", "MA:0001539", "MSH:D007422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014827 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." . [] oboInOwl:hasDbXref "GOC:mtg_muscle", "MA:0001523", "MSH:D041981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014831 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." . [] oboInOwl:hasDbXref "GOC:mr", "GOC:mtg_muscle", "PMID:11768524", "PMID:18276178", "PMID:538956" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014832 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:mtg_muscle", "MA:0000325", "MSH:D014551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014848 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014852 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014853 ; owl:annotatedTarget "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_muscle", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014860 ; owl:annotatedTarget "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0014860 ; owl:annotatedTarget "neurotransmitter secretion involved in control of skeletal muscle contraction" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_muscle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0014861 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015031 ; owl:annotatedTarget "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015106 ; owl:annotatedTarget "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." . [] a owl:Axiom ; rdfs:label "BESTs transport cytosolic HCO3- to extracellular region" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0015106 ; owl:annotatedTarget "Reactome:R-HSA-2752067" . [] oboInOwl:hasDbXref "GOC:mtg_transport", "ISBN:0815340729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015318 ; owl:annotatedTarget "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0395825172", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015629 ; owl:annotatedTarget "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015669 ; owl:annotatedTarget "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "Beilstein:2339601" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015671 ; owl:annotatedTarget "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015695 ; owl:annotatedTarget "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015697 ; owl:annotatedTarget "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015701 ; owl:annotatedTarget "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015711 ; owl:annotatedTarget "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015718 ; owl:annotatedTarget "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:krc", "PMID:12663868", "PMID:14699511" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015721 ; owl:annotatedTarget "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:vw", "GO_REF:0000069" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015749 ; owl:annotatedTarget "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015800 ; owl:annotatedTarget "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jsg", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015807 ; owl:annotatedTarget "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "CAS:50-22-6" . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015812 ; owl:annotatedTarget "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015833 ; owl:annotatedTarget "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015837 ; owl:annotatedTarget "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015844 ; owl:annotatedTarget "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015849 ; owl:annotatedTarget "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015850 ; owl:annotatedTarget "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015870 ; owl:annotatedTarget "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015872 ; owl:annotatedTarget "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015874 ; owl:annotatedTarget "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015925 ; owl:annotatedTarget "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "CAS:50-22-6" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0015980 ; owl:annotatedTarget "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:mah", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016020 ; owl:annotatedTarget "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016020 ; owl:annotatedTarget "transmembrane" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016043 ; owl:annotatedTarget "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016043 ; owl:annotatedTarget "cellular component organisation at cellular level" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016043 ; owl:annotatedTarget "cellular component organisation in other organism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016043 ; owl:annotatedTarget "cell organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016049 ; owl:annotatedTarget "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016049 ; owl:annotatedTarget "non-developmental cell growth" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016049 ; owl:annotatedTarget "non-developmental growth of a unicellular organism" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "CAS:50-22-6" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016050 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016050 ; owl:annotatedTarget "vesicle organization and biogenesis" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016051 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016052 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016053 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016064 ; owl:annotatedTarget "An immune response mediated by immunoglobulins, whether cell-bound or in solution." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016101 ; owl:annotatedTarget "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016125 ; owl:annotatedTarget "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016137 ; owl:annotatedTarget "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016160 ; owl:annotatedTarget "Catalysis of the hydrolysis of amylose or an amylose derivative." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02030186" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mah", "ISBN:08789310662000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016192 ; owl:annotatedTarget "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016192 ; owl:annotatedTarget "vesicular transport" . [] oboInOwl:hasDbXref "GOC:mah", "PMID:11121744" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016234 ; owl:annotatedTarget "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao120573470" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016234 ; owl:annotatedTarget "cellular inclusion" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016301 ; owl:annotatedTarget "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." . [] a owl:Axiom ; rdfs:label "FN3KRP phosphorylates PsiAm, RibAm" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016301 ; owl:annotatedTarget "Reactome:R-HSA-6788855" . [] a owl:Axiom ; rdfs:label "FN3K phosphorylates ketosamines" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016301 ; owl:annotatedTarget "Reactome:R-HSA-6788867" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016310 ; owl:annotatedTarget "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016311 ; owl:annotatedTarget "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "PMID:10438974" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016321 ; owl:annotatedTarget "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016331 ; owl:annotatedTarget "The process in which the anatomical structures of embryonic epithelia are generated and organized." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016406 ; owl:annotatedTarget "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016409 ; owl:annotatedTarget "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." . [] a owl:Axiom ; rdfs:label "palmitoylation of eNOS" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016409 ; owl:annotatedTarget "Reactome:R-HSA-203567" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "PMID:11448093" . [] a owl:Axiom ; rdfs:label "ZDHHC2 transfers PALM from PALM-CoA to CKAP4" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016409 ; owl:annotatedTarget "Reactome:R-HSA-5686304" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016416 ; owl:annotatedTarget "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." . [] a owl:Axiom ; rdfs:label "LRAT esterifies RBP1:atROL and FACYLs to atREs" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016416 ; owl:annotatedTarget "Reactome:R-HSA-2404137" . [] a owl:Axiom ; rdfs:label "LRAT esterifies RBP1:atROL and FACYLs to atREs" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016416 ; owl:annotatedTarget "Reactome:R-HSA-2453855" . [] a owl:Axiom ; rdfs:label "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016416 ; owl:annotatedTarget "Reactome:R-HSA-2466710" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016421 ; owl:annotatedTarget "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." . [] oboInOwl:hasDbXref "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016444 ; owl:annotatedTarget "Recombination occurring within or between DNA molecules in somatic cells." . [] oboInOwl:hasDbXref "GOC:add", "GOC:ma", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016445 ; owl:annotatedTarget "The somatic process that results in the generation of sequence diversity of immunoglobulins." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11205330", "PMID:11205333", "PMID:14975236", "PMID:7813007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016446 ; owl:annotatedTarget "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "PMID:16817814" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016447 ; owl:annotatedTarget "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0716743663", "PMID:16691483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016469 ; owl:annotatedTarget "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:dph", "GOC:ems", "GOC:pf", "Wikipedia:Cell_migration" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016477 ; owl:annotatedTarget "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:jl", "GOC:jsg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016485 ; owl:annotatedTarget "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016485 ; owl:annotatedTarget "protein maturation by peptide bond cleavage" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016485 ; owl:annotatedTarget "protein maturation by peptide bond hydrolysis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016485 ; owl:annotatedTarget "peptidolysis during protein maturation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016485 ; owl:annotatedTarget "protein maturation by proteolysis" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." . [] a owl:Axiom ; rdfs:label "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-1614362" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "PMID:24446162" . [] a owl:Axiom ; rdfs:label "Monoiodinated tyrosine can be deiodinated" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-209921" . [] a owl:Axiom ; rdfs:label "Diiodinated tyrosine can be deiodinated" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-209960" . [] a owl:Axiom ; rdfs:label "MMACHC dealkylates RCbl" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-3095889" . [] a owl:Axiom ; rdfs:label "FAR1 reduces PalmCoA to HXOL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-390425" . [] a owl:Axiom ; rdfs:label "FAR2 reduces PalmCoA to HXOL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-390438" . [] a owl:Axiom ; rdfs:label "Dopachrome is transformed to DHICA by DCT" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-5662660" . [] a owl:Axiom ; rdfs:label "TYRP1 oxidises DHICA to IQCA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-8878581" . [] a owl:Axiom ; rdfs:label "MARC1,MARC2 reduce N-hydroxylated compounds" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-8936442" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9020249" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9020260" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "11beta,21-dihydroxypregn-4-ene-3,20-dione" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9024624" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9024630" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9025007" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9026001" . [] a owl:Axiom ; rdfs:label "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9026917" . [] a owl:Axiom ; rdfs:label "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9027033" . [] a owl:Axiom ; rdfs:label "Unknown sepiapterin synthase transforms PTHP to sepiapterin" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016491 ; owl:annotatedTarget "Reactome:R-HSA-9693722" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "CORTICOSTERONE" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016525 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016614 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." . [] a owl:Axiom ; rdfs:label "Fgd1 reactivates F420" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016614 ; owl:annotatedTarget "Reactome:R-HSA-1500781" . [] oboInOwl:hasDbXref "EC:1.1.1.-", "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016616 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." . [] a owl:Axiom ; rdfs:label "RDH11 reduces RBP2:atRAL to RBP2:atROL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016616 ; owl:annotatedTarget "Reactome:R-HSA-975629" . [] oboInOwl:hasDbXref "EC:1.1.1.26" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016616 ; owl:annotatedTarget "glycolate reductase" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016620 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." . [] a owl:Axiom ; rdfs:label "MscR reduces nitrosomycothiol to ammonia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016620 ; owl:annotatedTarget "Reactome:R-HSA-1222583" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "Corticosterone" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016667 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." . [] a owl:Axiom ; rdfs:label "Reduction of disulphide bonds in MHC II antigens" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016667 ; owl:annotatedTarget "Reactome:R-HSA-2213240" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016670 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016740 ; owl:annotatedTarget "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." . [] a owl:Axiom ; rdfs:label "PE is converted to PS by PTDSS2" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016740 ; owl:annotatedTarget "Reactome:R-HSA-1483089" . [] a owl:Axiom ; rdfs:label "PC is converted to PS by PTDSS1" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016740 ; owl:annotatedTarget "Reactome:R-HSA-1483186" . [] a owl:Axiom ; rdfs:label "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016740 ; owl:annotatedTarget "Reactome:R-HSA-5668414" . [] a owl:Axiom ; rdfs:label "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016740 ; owl:annotatedTarget "Reactome:R-HSA-8868783" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." . [] a owl:Axiom ; rdfs:label "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Reactome:R-HSA-159431" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "corticosterone" . [] a owl:Axiom ; rdfs:label "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Reactome:R-HSA-192312" . [] a owl:Axiom ; rdfs:label "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Reactome:R-HSA-193491" . [] a owl:Axiom ; rdfs:label "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Reactome:R-HSA-6792572" . [] a owl:Axiom ; rdfs:label "HRASLS transfer acyl group from PC to PE to form NAPE" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016746 ; owl:annotatedTarget "Reactome:R-HSA-8858298" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016747 ; owl:annotatedTarget "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." . [] oboInOwl:hasDbXref "EC:2.3.1.-" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0016747 ; owl:annotatedTarget "transferase activity, transferring groups other than amino-acyl groups" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016769 ; owl:annotatedTarget "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016772 ; owl:annotatedTarget "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016774 ; owl:annotatedTarget "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione" . [] a owl:Axiom ; rdfs:label "Partial proteolysis of antigen in phagolysosomes" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-1236938" . [] a owl:Axiom ; rdfs:label "Production of AA by iPLA2 upon FCGR activation" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-2029475" . [] a owl:Axiom ; rdfs:label "ABHD4 hydrolyses NAPE" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-5694583" . [] a owl:Axiom ; rdfs:label "ABHD14B hydrolyses PNPB" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-5695964" . [] a owl:Axiom ; rdfs:label "CMBL hydrolyses OM to OLMS" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-6786190" . [] a owl:Axiom ; rdfs:label "HDHD1:Mg2+ dephosphorylates PURIDP" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-6788295" . [] a owl:Axiom ; rdfs:label "ENPPs hydrolyse CoA-SH to PPANT, PAP" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-8938314" . [] a owl:Axiom ; rdfs:label "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016787 ; owl:annotatedTarget "Reactome:R-HSA-8952137" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016788 ; owl:annotatedTarget "Catalysis of the hydrolysis of any ester bond." . [] a owl:Axiom ; rdfs:label "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016788 ; owl:annotatedTarget "Reactome:R-HSA-162729" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "11beta,21-Dihydroxy-4-pregnene-3,20-dione" . [] a owl:Axiom ; rdfs:label "Butyrylcholinesterase hydrolyzes acyl Ghrelin" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016788 ; owl:annotatedTarget "Reactome:R-HSA-9023617" . [] a owl:Axiom ; rdfs:label "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016788 ; owl:annotatedTarget "Reactome:R-HSA-9023619" . [] a owl:Axiom ; rdfs:label "BCHE hydrolyzes ASA-" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016788 ; owl:annotatedTarget "Reactome:R-HSA-9749609" . [] oboInOwl:hasDbXref "GOC:curators", "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016791 ; owl:annotatedTarget "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." . [] a owl:Axiom ; rdfs:label "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016791 ; owl:annotatedTarget "Reactome:R-HSA-4419986" . [] a owl:Axiom ; rdfs:label "SapM dephosphorylates PI3P" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016791 ; owl:annotatedTarget "Reactome:R-HSA-9636457" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016798 ; owl:annotatedTarget "Catalysis of the hydrolysis of any glycosyl bond." . [] a owl:Axiom ; rdfs:label "DS is cleaved from its proteoglycan" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016798 ; owl:annotatedTarget "Reactome:R-HSA-1793176" . [] a owl:Axiom ; rdfs:label "CS is cleaved from its proteoglycan" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016798 ; owl:annotatedTarget "Reactome:R-HSA-2065233" . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016829 ; owl:annotatedTarget "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "11beta,21-dihydroxyprogesterone" . [] a owl:Axiom ; rdfs:label "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016829 ; owl:annotatedTarget "Reactome:R-HSA-5696408" . [] a owl:Axiom ; rdfs:label "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016829 ; owl:annotatedTarget "Reactome:R-HSA-6782895" . [] oboInOwl:hasDbXref "EC:4.2.-.-" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016835 ; owl:annotatedTarget "Catalysis of the breakage of a carbon-oxygen bond." . [] oboInOwl:hasDbXref "EC:4.2.1.-" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016836 ; owl:annotatedTarget "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." . [] a owl:Axiom ; rdfs:label "SDS dimers:PXLP dehydrate L-Thr to 2AA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016836 ; owl:annotatedTarget "Reactome:R-HSA-9014627" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016853 ; owl:annotatedTarget "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." . [] a owl:Axiom ; rdfs:label "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0016853 ; owl:annotatedTarget "Reactome:R-HSA-6787623" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016866 ; owl:annotatedTarget "Catalysis of the transfer of a functional group from one position to another within a single molecule." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016868 ; owl:annotatedTarget "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016874 ; owl:annotatedTarget "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "17-deoxycortisol" . [] oboInOwl:hasDbXref "GOC:jh2" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0016874 ; owl:annotatedTarget "synthetase activity" . [] oboInOwl:hasDbXref "EC:6.4.-.-", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016885 ; owl:annotatedTarget "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0016903 ; owl:annotatedTarget "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." . [] oboInOwl:hasDbXref "GOC:jid", "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0017145 ; owl:annotatedTarget "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0017148 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "Kendall's compound B" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0017157 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of exocytosis." . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0018130 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0018958 ; owl:annotatedTarget "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16827 ; owl:annotatedTarget "Reichstein's substance H" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019098 ; owl:annotatedTarget "The specific behavior of an organism that is associated with reproduction." . [] oboInOwl:hasDbXref "GOC:mcc", "PMID:21696459", "PMID:7848303", "RHEA:27754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019172 ; owl:annotatedTarget "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019216 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019217 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019218 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019219 ; owl:annotatedTarget "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0019219 ; owl:annotatedTarget "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019220 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:signaling", "PMID:19295629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019221 ; owl:annotatedTarget "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019222 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0019222 ; owl:annotatedTarget "regulation of organismal metabolic process" . [] oboInOwl:hasDbXref "GOC:curators", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019226 ; owl:annotatedTarget "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0019226 ; owl:annotatedTarget "conduction of nerve impulse" . [] oboInOwl:hasDbXref "ISBN:072168677X" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019230 ; owl:annotatedTarget "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019233 ; owl:annotatedTarget "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019249 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019318 ; owl:annotatedTarget "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019319 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019438 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." . [] oboInOwl:hasDbXref "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019538 ; owl:annotatedTarget "The chemical reactions and pathways involving a protein. Includes protein modification." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019724 ; owl:annotatedTarget "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." . [] oboInOwl:hasDbXref "GOC:isa_complete", "GOC:jl", "ISBN:0395825172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019725 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state at the level of the cell." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019730 ; owl:annotatedTarget "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019747 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019748 ; owl:annotatedTarget "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019752 ; owl:annotatedTarget "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019755 ; owl:annotatedTarget "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:add", "GOC:jl", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019814 ; owl:annotatedTarget "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019815 ; owl:annotatedTarget "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0019815 ; owl:annotatedTarget "antibody" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019852 ; owl:annotatedTarget "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019866 ; owl:annotatedTarget "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." . [] oboInOwl:hasDbXref "GOC:add", "GO_REF:0000022", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019882 ; owl:annotatedTarget "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." . [] oboInOwl:hasDbXref "Wikipedia:Sexual_reproduction" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0019953 ; owl:annotatedTarget "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "Beilstein:1769194" . [] oboInOwl:hasDbXref "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0021700 ; owl:annotatedTarget "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." . [] oboInOwl:hasDbXref "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0021782 ; owl:annotatedTarget "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." . [] oboInOwl:hasDbXref "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0021915 ; owl:annotatedTarget "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." . [] oboInOwl:hasDbXref "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022008 ; owl:annotatedTarget "Generation of cells within the nervous system." . [] oboInOwl:hasSynonymType go:systematic_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0022008 ; owl:annotatedTarget "nervous system cell generation" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0022008 ; owl:annotatedTarget "neural cell differentiation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "CAS:503-49-1" . [] oboInOwl:hasDbXref "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022010 ; owl:annotatedTarget "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." . [] oboInOwl:hasDbXref "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022011 ; owl:annotatedTarget "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." . [] oboInOwl:hasDbXref "GOC:isa_complete", "GOC:mtg_cell_cycle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022402 ; owl:annotatedTarget "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "CAS:503-49-1" . [] oboInOwl:hasDbXref "GOC:mtg_cell_cycle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022403 ; owl:annotatedTarget "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022407 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "Drug_Central:1670" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022408 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022409 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of cell adhesion to another cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:10916782" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022410 ; owl:annotatedTarget "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022411 ; owl:annotatedTarget "A cellular process that results in the breakdown of a cellular component." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022412 ; owl:annotatedTarget "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:17941049" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022414 ; owl:annotatedTarget "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." . [] oboInOwl:hasDbXref "GOC:isa_complete", "GOC:jid", "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022600 ; owl:annotatedTarget "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:3063529" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022601 ; owl:annotatedTarget "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022603 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022607 ; owl:annotatedTarget "The aggregation, arrangement and bonding together of a cellular component." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:4717513" . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mtg_transport", "ISBN:0815340729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." . [] a owl:Axiom ; rdfs:label "Egress of internalized antigen to the cytosol via sec61" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-1236947" . [] a owl:Axiom ; rdfs:label "SLC2A9 transports Fru, Glc, urate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-429036" . [] a owl:Axiom ; rdfs:label "Defective SLC2A9 does not transport Fru, Glc, urate" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-5638209" . [] a owl:Axiom ; rdfs:label "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-5671707" . [] a owl:Axiom ; rdfs:label "An unknown carrier transports cytosolic glyoxylate to the peroxisome" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-6784434" . [] a owl:Axiom ; rdfs:label "An unknown carrier transports mitochondrial glyoxylate to the cytosol" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:GO_0022857 ; owl:annotatedTarget "Reactome:R-HSA-6784436" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:6083597" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_cardio", "GOC:mtg_transport" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0022898 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." . [] oboInOwl:hasDbXref "GOC:mtg_signal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023019 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023019 ; owl:annotatedTarget "regulation of gene expression as a consequence of signal transmission" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "PMID:9658458" . [] oboInOwl:hasDbXref "GOC:mtg_signal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023051 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a signaling process." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023051 ; owl:annotatedTarget "regulation of signaling process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023051 ; owl:annotatedTarget "regulation of signalling process" . [] oboInOwl:hasDbXref "GOC:mtg_signal", "GOC:mtg_signaling_feb11", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023052 ; owl:annotatedTarget "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023052 ; owl:annotatedTarget "signalling process" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "Reaxys:1769194" . [] oboInOwl:hasDbXref "GOC:mtg_signal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023056 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0023056 ; owl:annotatedTarget "positive regulation of signalling process" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023056 ; owl:annotatedTarget "positive regulation of signaling process" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "3-hydroxy-3-methylpentanedioic acid" . [] oboInOwl:hasDbXref "GOC:mtg_signal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023057 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023057 ; owl:annotatedTarget "negative regulation of signaling process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0023057 ; owl:annotatedTarget "negative regulation of signalling process" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "(S)-3-Hydroxy-3-methylglutaric acid" . [] oboInOwl:hasDbXref "GOC:mtg_signal" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0023061 ; owl:annotatedTarget "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0023061 ; owl:annotatedTarget "signal secretion" . [] oboInOwl:hasDbXref "GOC:ceb", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030003 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." . [] oboInOwl:hasDbXref "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030016 ; owl:annotatedTarget "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." . [] oboInOwl:hasDbXref "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030017 ; owl:annotatedTarget "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah", "http://www.cogsci.princeton.edu/~wn/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030030 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030030 ; owl:annotatedTarget "cell projection organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030030 ; owl:annotatedTarget "cell surface structure organization and biogenesis" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "(S)-Meglutol" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah", "http://www.cogsci.princeton.edu/~wn/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030031 ; owl:annotatedTarget "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030031 ; owl:annotatedTarget "cell projection biogenesis" . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "GOC:mah", "ISBN:0198506732", "PMID:26820516", "PMID:28096264", "http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030054 ; owl:annotatedTarget "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030072 ; owl:annotatedTarget "The regulated release of a peptide hormone from a cell." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030073 ; owl:annotatedTarget "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." . [] oboInOwl:hasDbXref "GOC:dgh", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030097 ; owl:annotatedTarget "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." . [] oboInOwl:hasDbXref "CL:0000542", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030098 ; owl:annotatedTarget "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030098 ; owl:annotatedTarget "lymphocyte development" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030099 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "3-HYDROXY-3-METHYL-GLUTARIC ACID" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030100 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of endocytosis." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030103 ; owl:annotatedTarget "The regulated release of vasopressin from secretory granules into the blood." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030141 ; owl:annotatedTarget "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030154 ; owl:annotatedTarget "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "3-Hydroxy-3-methylpentanedioic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030155 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "Dicrotalic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030162 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." . [] oboInOwl:hasDbXref "http://www.graylab.ac.uk/omd/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030168 ; owl:annotatedTarget "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." . [] oboInOwl:hasDbXref "GOC:add", "GOC:pde" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030168 ; owl:annotatedTarget "blood coagulation, platelet activation" . [] oboInOwl:hasDbXref "GOC:mah", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030183 ; owl:annotatedTarget "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030183 ; owl:annotatedTarget "B cell development" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030186 ; owl:annotatedTarget "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030187 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "beta-Hydroxy-beta-methylglutaric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030193 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood coagulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "beta-hydroxy-beta-methylglutaric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030194 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood coagulation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030195 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030198 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030198 ; owl:annotatedTarget "extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030202 ; owl:annotatedTarget "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "meglutol" . [] oboInOwl:hasDbXref "ISBN:0192800981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030203 ; owl:annotatedTarget "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030210 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030216 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030217 ; owl:annotatedTarget "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0030217 ; owl:annotatedTarget "T cell development" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030218 ; owl:annotatedTarget "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030218 ; owl:annotatedTarget "RBC differentiation" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030218 ; owl:annotatedTarget "erythropoiesis" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "meglutol" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030218 ; owl:annotatedTarget "red blood cell differentiation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030219 ; owl:annotatedTarget "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030221 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030224 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030225 ; owl:annotatedTarget "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030252 ; owl:annotatedTarget "The regulated release of growth hormone from secretory granules into the blood." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030252 ; owl:annotatedTarget "somatotropin secretion" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030261 ; owl:annotatedTarget "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." . [] oboInOwl:hasDbXref "Wikipedia:DNA_condensation" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0030261 ; owl:annotatedTarget "DNA condensation" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030261 ; owl:annotatedTarget "eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16831 ; owl:annotatedTarget "meglutolum" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030261 ; owl:annotatedTarget "nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030262 ; owl:annotatedTarget "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030263 ; owl:annotatedTarget "The compaction of chromatin during apoptosis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030278 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030279 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." . [] oboInOwl:hasDbXref "GOC:mah", "PMID:22936354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030282 ; owl:annotatedTarget "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030307 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, extent or direction of cell growth." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030308 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030312 ; owl:annotatedTarget "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." . [] oboInOwl:hasDbXref "CL:0000092", "GOC:add", "ISBN:0781735149", "PMID:12161749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030316 ; owl:annotatedTarget "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000060", "PMID:26680031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030317 ; owl:annotatedTarget "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030317 ; owl:annotatedTarget "sperm flagellum movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030317 ; owl:annotatedTarget "sperm flagellum movement involved in flagellated sperm movement" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030323 ; owl:annotatedTarget "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." . [] oboInOwl:hasDbXref "GOC:jid", "UBERON:0002048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030324 ; owl:annotatedTarget "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030334 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell migration." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030335 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell migration." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030336 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030421 ; owl:annotatedTarget "The expulsion of feces from the rectum." . [] oboInOwl:hasDbXref "GOC:nln", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030424 ; owl:annotatedTarget "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "GOC:dos", "GOC:mah", "GOC:nln", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030425 ; owl:annotatedTarget "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." . [] oboInOwl:hasDbXref "ISBN:0192800981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030431 ; owl:annotatedTarget "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030432 ; owl:annotatedTarget "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030449 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of complement activation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030449 ; owl:annotatedTarget "regulation of complement cascade" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030500 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bone mineralization." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "Beilstein:906818" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030501 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bone mineralization." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030502 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030593 ; owl:annotatedTarget "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "CAS:56-12-2" . [] oboInOwl:hasDbXref "GOC:add", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030595 ; owl:annotatedTarget "The movement of a leukocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030656 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "CAS:56-12-2" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030659 ; owl:annotatedTarget "The lipid bilayer surrounding a cytoplasmic vesicle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030667 ; owl:annotatedTarget "The lipid bilayer surrounding a secretory granule." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030705 ; owl:annotatedTarget "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." . [] oboInOwl:hasDbXref "GOC:ecd", "http://life.nthu.edu.tw/~g864204/dict-search1.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030851 ; owl:annotatedTarget "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "CAS:56-12-2" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030852 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of granulocyte differentiation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030853 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "Drug_Central:1262" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030854 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." . [] oboInOwl:hasDbXref "GOC:ecd", "PMID:11839751" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030855 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "Gmelin:49775" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030856 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030857 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01100039" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030858 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." . [] oboInOwl:hasDbXref "PMID:9576833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030879 ; owl:annotatedTarget "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0030879 ; owl:annotatedTarget "mammogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "PMID:10630630" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030885 ; owl:annotatedTarget "Any process that modulates the frequency or rate of myeloid dendritic cell activation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030886 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "PMID:10930630" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030887 ; owl:annotatedTarget "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "PMID:16276116" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030888 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of B cell proliferation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030889 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "PMID:21614609" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030890 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of B cell proliferation." . [] oboInOwl:hasDbXref "ISBN:0721639976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030936 ; owl:annotatedTarget "Any collagen trimer that passes through a lipid bilayer membrane." . [] oboInOwl:hasDbXref "ISBN:0198599587" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0030936 ; owl:annotatedTarget "MACIT" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:kmv", "PMID:14570576", "PMID:22118932", "PMID:23945166" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0030990 ; owl:annotatedTarget "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah", "GOC:rph", "NIF_Subcellular:nlx_subcell_20090513", "PMID:21123617", "PMID:28089324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031012 ; owl:annotatedTarget "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:ns", "PMID:18708581", "PMID:24886889", "PMID:32986476" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031049 ; owl:annotatedTarget "A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing." . [] oboInOwl:hasDbXref "GOC:ns", "PMID:15956677", "PMID:25303953", "PMID:32165395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031052 ; owl:annotatedTarget "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031090 ; owl:annotatedTarget "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao830981606" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031090 ; owl:annotatedTarget "intracellular membrane" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "Reaxys:906818" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031099 ; owl:annotatedTarget "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." . [] oboInOwl:hasDbXref "PMID:15132736" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031214 ; owl:annotatedTarget "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031268 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031268 ; owl:annotatedTarget "pseudopodium organization and biogenesis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4-aminobutanoic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031323 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031324 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "gamma-Aminobutyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031325 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031326 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "gamma-aminobutyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031327 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4-Aminobutanoic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031328 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031329 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4-Aminobutyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031330 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031331 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4-aminobutanoic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031335 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4-aminobutyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031336 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031337 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "4Abu" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031338 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of vesicle fusion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031339 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "GABA" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031340 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of vesicle fusion." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "GABA" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031341 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031342 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "GAMMA-AMINO-BUTANOIC ACID" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031343 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell killing." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031344 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031344 ; owl:annotatedTarget "regulation of cell projection organization and biogenesis" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "gamma-Aminobuttersaeure" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031345 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0031345 ; owl:annotatedTarget "down regulation of cell projection organization" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031345 ; owl:annotatedTarget "negative regulation of cell projection organization and biogenesis" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "gamma-amino-n-butyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031346 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031346 ; owl:annotatedTarget "positive regulation of cell projection organization and biogenesis" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "gamma-aminobutanoic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031347 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a defense response." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031348 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "omega-aminobutyric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031349 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a defense response." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031399 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "piperidic acid" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031400 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16865 ; owl:annotatedTarget "piperidinic acid" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031401 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mah", "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031410 ; owl:annotatedTarget "A vesicle found in the cytoplasm of a cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ebc", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031424 ; owl:annotatedTarget "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031503 ; owl:annotatedTarget "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0031503 ; owl:annotatedTarget "protein complex localisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031503 ; owl:annotatedTarget "cellular protein complex localisation" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:dgh", "GOC:kmv", "PMID:17009929", "PMID:20144998", "PMID:22118931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031514 ; owl:annotatedTarget "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." . [] oboInOwl:hasDbXref "GOC:nln" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031594 ; owl:annotatedTarget "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." . [] oboInOwl:hasDbXref "GOC:ha" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031594 ; owl:annotatedTarget "NMJ" . [] oboInOwl:hasDbXref "NIF_Subcellular:nlx_subcell_20090512" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0031594 ; owl:annotatedTarget "motor endplate" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031640 ; owl:annotatedTarget "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031641 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031642 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031643 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031644 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0031644 ; owl:annotatedTarget "regulation of neurological process" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031645 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0031645 ; owl:annotatedTarget "negative regulation of neurological process" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031646 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0031646 ; owl:annotatedTarget "positive regulation of neurological process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031667 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031943 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031944 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031945 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Beilstein:907175" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031946 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031947 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "CAS:57-00-1" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031948 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031965 ; owl:annotatedTarget "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "CAS:57-00-1" . [] oboInOwl:hasDbXref "GOC:mah", "NIF_Subcellular:sao1045389829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031966 ; owl:annotatedTarget "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031967 ; owl:annotatedTarget "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031974 ; owl:annotatedTarget "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031975 ; owl:annotatedTarget "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "CAS:57-00-1" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031981 ; owl:annotatedTarget "The volume enclosed by the nuclear inner membrane." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:pz", "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031982 ; owl:annotatedTarget "Any small, fluid-filled, spherical organelle enclosed by membrane." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0031987 ; owl:annotatedTarget "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Drug_Central:4661" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032024 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Gmelin:240513" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032042 ; owl:annotatedTarget "The chemical reactions and pathways involving mitochondrial DNA." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032055 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:11356982" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032056 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mtg_apoptosis", "PMID:12083798", "PMID:16624291", "Wikipedia:Bleb_(cell_biology)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032060 ; owl:annotatedTarget "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0032060 ; owl:annotatedTarget "blebbing" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0032060 ; owl:annotatedTarget "membrane blebbing" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032060 ; owl:annotatedTarget "plasma membrane bleb assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:11483809" . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032060 ; owl:annotatedTarget "plasma membrane blebbing" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032098 ; owl:annotatedTarget "Any process which modulates appetite, the desire or physical craving for food." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032101 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a response to an external stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:11867929" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032102 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:12085493" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032103 ; owl:annotatedTarget "Any process that activates, maintains or increases the rate of a response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032104 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:12184144" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032105 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032106 ; owl:annotatedTarget "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:12878267" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032107 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a response to nutrient levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:16445883" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032108 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032109 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032222 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032223 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:17253521" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032224 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:17416441" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032228 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032229 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:18555535" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032230 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032274 ; owl:annotatedTarget "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032275 ; owl:annotatedTarget "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:19082141" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032276 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032277 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032277 ; owl:annotatedTarget "negative regulation of gonadotrophin secretion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:19651674" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032278 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032278 ; owl:annotatedTarget "positive regulation of gonadotrophin secretion" . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032286 ; owl:annotatedTarget "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032288 ; owl:annotatedTarget "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0032288 ; owl:annotatedTarget "myelin formation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:19741514" . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032289 ; owl:annotatedTarget "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032291 ; owl:annotatedTarget "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032292 ; owl:annotatedTarget "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032350 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:19968328" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032351 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:21556832" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032352 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032353 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:21660517" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032368 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032369 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:21698493" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032370 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22038587" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032386 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032387 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22101931" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032388 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032409 ; owl:annotatedTarget "Any process that modulates the activity of a transporter." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22196490" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032410 ; owl:annotatedTarget "Any process that stops or reduces the activity of a transporter." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22252611" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032411 ; owl:annotatedTarget "Any process that activates or increases the activity of a transporter." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032432 ; owl:annotatedTarget "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0032432 ; owl:annotatedTarget "actin cable" . [] oboInOwl:hasDbXref "GOC:curators", "GOC:dph", "GOC:isa_complete", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032501 ; owl:annotatedTarget "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032502 ; owl:annotatedTarget "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." . [] oboInOwl:hasDbXref "GOC:isa_complete", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032504 ; owl:annotatedTarget "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22347384" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032543 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22386973" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032594 ; owl:annotatedTarget "The directed movement of a protein from one location to another within a lipid bilayer." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:rl", "ISBN:0198506732", "PMID:12183377", "Wikipedia:Chemokine" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032602 ; owl:annotatedTarget "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "PMID:15546383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032609 ; owl:annotatedTarget "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032609 ; owl:annotatedTarget "IFNG production" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032609 ; owl:annotatedTarget "type II IFN production" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22422801" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032642 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of chemokine production." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "PMID:15546383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032649 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." . [] obo:IAO_0000116 "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional." ; a owl:Axiom ; owl:annotatedProperty rdfs:range ; owl:annotatedSource obo:RO_0002551 ; owl:annotatedTarget obo:UBERON_0000465 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22429992" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032682 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22465051" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "PMID:15546383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032689 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032722 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of chemokine production." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:22521466" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "PMID:15546383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032729 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." . [] oboInOwl:hasDbXref "GOC:ecd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032782 ; owl:annotatedTarget "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:vk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032787 ; owl:annotatedTarget "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "PMID:7752905" . [] oboInOwl:hasDbXref "GOC:vk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032811 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." . [] oboInOwl:hasDbXref "GOC:vk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032812 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Reaxys:907175" . [] oboInOwl:hasDbXref "GOC:krc", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032838 ; owl:annotatedTarget "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032839 ; owl:annotatedTarget "All of the contents of a dendrite, excluding the surrounding plasma membrane." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Creatine" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032879 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032879 ; owl:annotatedTarget "regulation of localisation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-[amino(imino)methyl]-N-methylglycine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032880 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032880 ; owl:annotatedTarget "regulation of cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032880 ; owl:annotatedTarget "regulation of protein localisation" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "((amino(imino)methyl)(methyl)amino)acetic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032881 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032885 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "(N-methylcarbamimidamido)acetic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032886 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032890 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "(alpha-methylguanido)acetic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032891 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "(alpha-methylguanido)acetic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032892 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032940 ; owl:annotatedTarget "The controlled release of a substance by a cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032941 ; owl:annotatedTarget "The controlled release of a substance by a tissue." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0032941 ; owl:annotatedTarget "expulsion of gland contents" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032943 ; owl:annotatedTarget "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Creatin" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032944 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032945 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Kreatin" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032946 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032989 ; owl:annotatedTarget "The process in which cellular structures, including whole cells or cell parts, are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032989 ; owl:annotatedTarget "cellular structure morphogenesis" . [] oboInOwl:hasDbXref "GOC:dos", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032991 ; owl:annotatedTarget "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032993 ; owl:annotatedTarget "A macromolecular complex containing both protein and DNA molecules." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0032993 ; owl:annotatedTarget "DNA-protein complex" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032994 ; owl:annotatedTarget "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0032997 ; owl:annotatedTarget "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "Methylglycocyamine" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:11244038", "PMID:12413532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033001 ; owl:annotatedTarget "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033013 ; owl:annotatedTarget "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033014 ; owl:annotatedTarget "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033036 ; owl:annotatedTarget "Any process in which a macromolecule is transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033036 ; owl:annotatedTarget "macromolecule localisation" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-(aminoiminomethyl)-N-methylglycine" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033043 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033043 ; owl:annotatedTarget "regulation of organelle organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0033043 ; owl:annotatedTarget "regulation of organelle organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033044 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033044 ; owl:annotatedTarget "regulation of chromosome organisation" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-Methyl-N-guanylglycine" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0033044 ; owl:annotatedTarget "regulation of chromosome organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033045 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sister chromatid segregation." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-[(E)-AMINO(IMINO)METHYL]-N-METHYLGLYCINE" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033046 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033047 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-amidinosarcosine" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033048 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781700221", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033151 ; owl:annotatedTarget "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "immunoglobulin V(D)J joining" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "immunoglobulin V-D-J joining" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "immunoglobulin V-D-J recombination" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-carbamimidoyl-N-methylglycine" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "immunoglobulin V-J joining" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0033152 ; owl:annotatedTarget "immunoglobulin V-J recombination" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033157 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "N-methyl-N-guanylglycine" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033238 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033239 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." . [] obo:IAO_0000116 "This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation." ; a owl:Axiom ; owl:annotatedProperty rdfs:domain ; owl:annotatedSource obo:RO_0001025 ; owl:annotatedTarget obo:BFO_0000004 . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16919 ; owl:annotatedTarget "alpha-Methylguanidino acetic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033240 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033363 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033363 ; owl:annotatedTarget "secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0033363 ; owl:annotatedTarget "secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033365 ; owl:annotatedTarget "A process in which a protein is transported to, or maintained in, a location within an organelle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033365 ; owl:annotatedTarget "protein localisation to organelle" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0033365 ; owl:annotatedTarget "protein localization in organelle" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033500 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033554 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033559 ; owl:annotatedTarget "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033602 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033603 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033604 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033605 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "Beilstein:82133" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033673 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "CAS:4042-36-8" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033674 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033684 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "CAS:4042-36-8" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033685 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0033686 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "Gmelin:1473408" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034097 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034097 ; owl:annotatedTarget "response to cytokine stimulus" . [] oboInOwl:hasDbXref "GOC:add", "PMID:10694114", "PMID:14754397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034101 ; owl:annotatedTarget "Any process of regulating the production and elimination of erythrocytes within an organism." . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034101 ; owl:annotatedTarget "RBC homeostasis" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034101 ; owl:annotatedTarget "red blood cell homeostasis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034103 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of tissue remodeling." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034104 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "Reaxys:82133" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034105 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034109 ; owl:annotatedTarget "The attachment of a cell to a second cell of the identical type via adhesion molecules." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034110 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "(2R)-5-oxopyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034111 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "5-Oxo-D-proline" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034112 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034219 ; owl:annotatedTarget "The process in which a carbohydrate is transported across a membrane." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034219 ; owl:annotatedTarget "transmembrane carbohydrate transport" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034220 ; owl:annotatedTarget "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034220 ; owl:annotatedTarget "transmembrane ion transport" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "5-oxo-D-proline" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034248 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034249 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "D-5-Pyrrolidone-2-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034250 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:expert_pt", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034358 ; owl:annotatedTarget "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah", "GOC:pde", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034435 ; owl:annotatedTarget "OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." . [] oboInOwl:hasDbXref "GOC:mah", "MP:0002817", "MSH:D014074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034505 ; owl:annotatedTarget "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034641 ; owl:annotatedTarget "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16924 ; owl:annotatedTarget "D-Pyroglutamic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034762 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034763 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034764 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034765 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034765 ; owl:annotatedTarget "regulation of transmembrane ion transport" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034766 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0034766 ; owl:annotatedTarget "negative regulation of transmembrane ion transport" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034767 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "Beilstein:1884707" . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0034982 ; owl:annotatedTarget "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:cilia", "GOC:jl", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035082 ; owl:annotatedTarget "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0035082 ; owl:annotatedTarget "axoneme biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0035082 ; owl:annotatedTarget "cilium axoneme biogenesis" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035148 ; owl:annotatedTarget "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "CAS:126-44-3" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035148 ; owl:annotatedTarget "tube lumen formation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0035148 ; owl:annotatedTarget "lumen formation in an anatomical structure" . [] oboInOwl:hasDbXref "GOC:jh2", "PMID:12848939", "Wikipedia:Social_behavior" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035176 ; owl:annotatedTarget "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." . [] oboInOwl:hasDbXref "GOC:bf", "PMID:14624839" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035239 ; owl:annotatedTarget "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035249 ; owl:annotatedTarget "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." . [] oboInOwl:hasDbXref "GOC:bf", "ISBN:0471245208", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035265 ; owl:annotatedTarget "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." . [] oboInOwl:hasDbXref "PMID:10611687", "PMID:9706689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035282 ; owl:annotatedTarget "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." . [] oboInOwl:hasDbXref "PMID:12526790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035295 ; owl:annotatedTarget "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "Gmelin:4239" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035303 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "Reaxys:1884707" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035305 ; owl:annotatedTarget "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035306 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:16464608", "PMID:17306522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035369 ; owl:annotatedTarget "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "2-hydroxypropane-1,2,3-tricarboxylate" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:jl", "GOC:signaling", "ISBN:3527303782" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035556 ; owl:annotatedTarget "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." . [] oboInOwl:hasDbXref "ISBN:3527303782" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035556 ; owl:annotatedTarget "intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0035556 ; owl:annotatedTarget "intracellular protein kinase cascade" . [] oboInOwl:hasDbXref "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0035556 ; owl:annotatedTarget "protein kinase cascade" . [] oboInOwl:hasDbXref "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0035556 ; owl:annotatedTarget "intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035592 ; owl:annotatedTarget "The directed movement of a protein to a specific location within the extracellular region." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "2-hydroxy-1,2,3-propanetricarboxylate" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035592 ; owl:annotatedTarget "establishment of protein localisation in extracellular region" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035630 ; owl:annotatedTarget "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "2-hydroxy-1,2,3-propanetricarboxylate(3-)" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:cilia", "Reactome:R-HSA-5620924.2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035735 ; owl:annotatedTarget "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." . [] oboInOwl:hasDbXref "GOC:mtg_25march11", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035809 ; owl:annotatedTarget "Any process that modulates the amount of urine excreted from the body over a unit of time." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035821 ; owl:annotatedTarget "The process in which an organism effects a change in the structure or processes of another organism." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0035821 ; owl:annotatedTarget "regulation of morphology of other organism" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0035821 ; owl:annotatedTarget "regulation of physiological process of other organism" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0035821 ; owl:annotatedTarget "regulation of physiology of other organism" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0035821 ; owl:annotatedTarget "regulation of morphology or physiology of other organism" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-)" . [] oboInOwl:hasDbXref "GOC:bf", "ISBN:0323025781", "UBERON:0001705", "Wikipedia:Nail_(anatomy)" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035878 ; owl:annotatedTarget "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." . [] oboInOwl:hasDbXref "GOC:cjm", "PMID:12171519", "PMID:21164021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035898 ; owl:annotatedTarget "The regulated release of parathyroid hormone into the circulatory system." . [] oboInOwl:hasDbXref "PMID:12171519", "PR:000013429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035898 ; owl:annotatedTarget "PTH secretion" . [] oboInOwl:hasDbXref "PR:000013429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035898 ; owl:annotatedTarget "parathormone secretion" . [] oboInOwl:hasDbXref "PR:000013429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0035898 ; owl:annotatedTarget "parathyrin secretion" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035929 ; owl:annotatedTarget "The regulated release of any steroid that acts as a hormone into the circulatory system." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035930 ; owl:annotatedTarget "The regulated release of any corticosteroid hormone into the circulatory system." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0035930 ; owl:annotatedTarget "corticosteroid secretion" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035931 ; owl:annotatedTarget "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035932 ; owl:annotatedTarget "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "2-hydroxytricarballylate" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035935 ; owl:annotatedTarget "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." . [] oboInOwl:hasDbXref "GOC:sl", "PMID:12606499" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0035936 ; owl:annotatedTarget "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." . [] oboInOwl:hasDbXref "GOC:sart", "PMID:19948734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036065 ; owl:annotatedTarget "The covalent attachment of a fucosyl group to an acceptor molecule." . [] oboInOwl:hasDbXref "GOC:sart", "PMID:19948734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036066 ; owl:annotatedTarget "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036072 ; owl:annotatedTarget "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036075 ; owl:annotatedTarget "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0036075 ; owl:annotatedTarget "indirect ossification" . [] oboInOwl:hasDbXref "GOC:cjm", "Wikipedia:Melanocyte-stimulating_hormone" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036160 ; owl:annotatedTarget "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0036160 ; owl:annotatedTarget "MSH secretion" . [] oboInOwl:hasDbXref "GOC:cjm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036161 ; owl:annotatedTarget "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "CITRATE ANION" . [] oboInOwl:hasDbXref "CL:0000187", "GOC:kmv", "PMID:15930100", "PMID:22464329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036194 ; owl:annotatedTarget "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." . [] oboInOwl:hasDbXref "CL:0000187" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0036194 ; owl:annotatedTarget "myocyte projection" . [] oboInOwl:hasDbXref "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0036194 ; owl:annotatedTarget "muscle arm" . [] oboInOwl:hasDbXref "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0036194 ; owl:annotatedTarget "myopodia" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036211 ; owl:annotatedTarget "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0036211 ; owl:annotatedTarget "protein modification" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:pad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0036477 ; owl:annotatedTarget "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0038023 ; owl:annotatedTarget "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0038023 ; owl:annotatedTarget "receptor activity involved in signal transduction" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040007 ; owl:annotatedTarget "The increase in size or mass of an entire organism, a part of an organism or a cell." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "cit" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0040007 ; owl:annotatedTarget "non-developmental growth" . [] oboInOwl:hasDbXref "GOC:ems", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040008 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040011 ; owl:annotatedTarget "Self-propelled movement of a cell or organism from one location to another." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "cit(3-)" . [] oboInOwl:hasDbXref "GOC:ems" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040012 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040013 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16947 ; owl:annotatedTarget "citrate" . [] oboInOwl:hasDbXref "GOC:clt", "ISBN:0070524300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040016 ; owl:annotatedTarget "The first few specialized divisions of an activated animal egg." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040017 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040019 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of embryonic development." . [] oboInOwl:hasDbXref "GOC:ems", "GOC:ma" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040020 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0040020 ; owl:annotatedTarget "regulation of meiosis" . [] oboInOwl:hasDbXref "PMID:10521337", "PMID:11498582", "PMID:22243696", "PMID:34414474" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0040029 ; owl:annotatedTarget "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042044 ; owl:annotatedTarget "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:bf", "PMID:15269788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042060 ; owl:annotatedTarget "The series of events that restore integrity to a damaged tissue, following an injury." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042063 ; owl:annotatedTarget "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." . [] oboInOwl:hasSynonymType go:systematic_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042063 ; owl:annotatedTarget "glial cell generation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042065 ; owl:annotatedTarget "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:kmv", "PMID:17981739", "PMID:18180368", "PMID:22869374", "Reactome:R-HSA-5620924.2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042073 ; owl:annotatedTarget "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0878932437", "http://www.cellmigration.org/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042074 ; owl:annotatedTarget "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:18000958", "PMID:18007680", "PMID:20065995", "PMID:20200518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042092 ; owl:annotatedTarget "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0042092 ; owl:annotatedTarget "T-helper 2 type immune response" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0042092 ; owl:annotatedTarget "Th2 immune response" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042098 ; owl:annotatedTarget "The expansion of a T cell population by cell division. Follows T cell activation." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042100 ; owl:annotatedTarget "The expansion of a B cell population by cell division. Follows B cell activation." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042101 ; owl:annotatedTarget "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042101 ; owl:annotatedTarget "TCR complex" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042102 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of T cell proliferation." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042105 ; owl:annotatedTarget "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042106 ; owl:annotatedTarget "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." . [] oboInOwl:hasDbXref "GOC:mgi_curators", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042110 ; owl:annotatedTarget "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." . [] oboInOwl:hasDbXref "GOC:mgi_curators", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042113 ; owl:annotatedTarget "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042127 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell proliferation." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042129 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of T cell proliferation." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042130 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0124325653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042168 ; owl:annotatedTarget "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0787650153" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042180 ; owl:annotatedTarget "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042182 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042221 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042221 ; owl:annotatedTarget "response to chemical stimulus" . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042246 ; owl:annotatedTarget "The regrowth of lost or destroyed tissues." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "Beilstein:906793" . [] oboInOwl:hasDbXref "GOC:jl", "PMID:11506998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042320 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "CAS:107-95-9" . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:jl", "ISBN:0192800981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042321 ; owl:annotatedTarget "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042322 ; owl:annotatedTarget "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "CAS:107-95-9" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042325 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042326 ; owl:annotatedTarget "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "CAS:107-95-9" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042327 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042330 ; owl:annotatedTarget "The directed movement of a motile cell or organism in response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0471331309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042359 ; owl:annotatedTarget "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042360 ; owl:annotatedTarget "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." . [] oboInOwl:hasDbXref "GOC:jl", "http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042373 ; owl:annotatedTarget "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "Gmelin:49614" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_cardio", "GOC:tb", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042391 ; owl:annotatedTarget "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042403 ; owl:annotatedTarget "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042405 ; owl:annotatedTarget "An intranuclear focus at which aggregated proteins have been sequestered." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042430 ; owl:annotatedTarget "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:11139233" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042435 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042440 ; owl:annotatedTarget "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042445 ; owl:annotatedTarget "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042446 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0192801023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042465 ; owl:annotatedTarget "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." . [] oboInOwl:hasDbXref "GOC:jl", "PMID:11584301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042470 ; owl:annotatedTarget "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:mah", "GOC:mtg_sensu", "PMID:10333884", "PMID:15355794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042475 ; owl:annotatedTarget "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042475 ; owl:annotatedTarget "odontogenesis of dentine-containing tooth" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042476 ; owl:annotatedTarget "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:11850512" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042481 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:12107759" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042482 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042483 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:12887142" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_sensu", "PMID:15355794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042487 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042487 ; owl:annotatedTarget "regulation of odontogenesis of dentine-containing tooth" . [] oboInOwl:hasDbXref "GOC:jl", "PMID:15355794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042488 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:14363188" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_sensu", "PMID:15355794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042489 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." . [] oboInOwl:hasDbXref "CL:0000798", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042492 ; owl:annotatedTarget "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0042492 ; owl:annotatedTarget "gamma-delta T cell development" . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042552 ; owl:annotatedTarget "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." . [] oboInOwl:hasDbXref "GOC:cjm", "HP:0003429" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0042552 ; owl:annotatedTarget "myelinogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:16934791" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042571 ; owl:annotatedTarget "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0042571 ; owl:annotatedTarget "antibody" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042578 ; owl:annotatedTarget "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." . [] oboInOwl:hasDbXref "GOC:jl", "PMID:17152095" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042582 ; owl:annotatedTarget "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042588 ; owl:annotatedTarget "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042589 ; owl:annotatedTarget "The lipid bilayer surrounding a zymogen granule." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0395825172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042592 ; owl:annotatedTarget "Any biological process involved in the maintenance of an internal steady state." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042593 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:18528519" . [] oboInOwl:hasDbXref "GOC:add", "GOC:jl", "ISBN:0781735149", "PMID:15928678", "PMID:16153240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042611 ; owl:annotatedTarget "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." . [] oboInOwl:hasDbXref "GOC:add", "GOC:jl", "ISBN:0120781859", "PMID:15928678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042613 ; owl:annotatedTarget "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:rl", "PMID:10580165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042627 ; owl:annotatedTarget "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042645 ; owl:annotatedTarget "The region of a mitochondrion to which the DNA is confined." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:18613640" . [] oboInOwl:hasDbXref "GOC:curators", "PMID:19117864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042695 ; owl:annotatedTarget "The beginning of development of the breasts in the female." . [] oboInOwl:hasDbXref "GOC:curators", "PMID:16311040" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042696 ; owl:annotatedTarget "The beginning of the menstrual cycle; the first menstrual cycle in an individual." . [] oboInOwl:hasDbXref "GOC:curators", "PMID:8693059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042703 ; owl:annotatedTarget "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." . [] oboInOwl:hasDbXref "GOC:jl", "http://www.cogsci.princeton.edu/~wn/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042713 ; owl:annotatedTarget "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." . [] oboInOwl:hasDbXref "GOC:jl", "PMID:15842654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042730 ; owl:annotatedTarget "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042742 ; owl:annotatedTarget "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." . [] oboInOwl:hasDbXref "GOC:jl", "http://www.sleepquest.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042745 ; owl:annotatedTarget "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0395825172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042747 ; owl:annotatedTarget "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:19239140" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042749 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:19955842" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042752 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042753 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:20199122" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042754 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:pr", "PMID:19361967" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042755 ; owl:annotatedTarget "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042756 ; owl:annotatedTarget "The specific behavior of an organism relating to the intake of liquids, especially water." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:20386120" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042762 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042886 ; owl:annotatedTarget "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042981 ; owl:annotatedTarget "Any process that modulates the occurrence or rate of cell death by apoptotic process." . [] oboInOwl:hasDbXref "GOC:jl", "http://www.cogsci.princeton.edu/~wn/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0042995 ; owl:annotatedTarget "A prolongation or process extending from a cell, e.g. a flagellum or axon." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:20479615" . [] oboInOwl:hasDbXref "GOC:jl", "http://www.cogsci.princeton.edu/~wn/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043005 ; owl:annotatedTarget "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao250931889" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043005 ; owl:annotatedTarget "neuron protrusion" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043005 ; owl:annotatedTarget "nerve fiber" . [] oboInOwl:hasDbXref "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043009 ; owl:annotatedTarget "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." . [] oboInOwl:hasDbXref "CL:0000782", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043011 ; owl:annotatedTarget "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043025 ; owl:annotatedTarget "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043043 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043062 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043062 ; owl:annotatedTarget "extracellular structure organization and biogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:20994958" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043065 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043066 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043067 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "Reaxys:906793" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043068 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043069 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "3-aminopropanoic acid" . [] oboInOwl:hasDbXref "GOC:jl", "Wikipedia:Penile_erection" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043084 ; owl:annotatedTarget "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." . [] oboInOwl:hasDbXref "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043085 ; owl:annotatedTarget "Any process that activates or increases the activity of an enzyme." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043085 ; owl:annotatedTarget "positive regulation of enzyme activity" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "BETA-ALANINE" . [] oboInOwl:hasDbXref "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043086 ; owl:annotatedTarget "Any process that stops or reduces the activity of an enzyme." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043086 ; owl:annotatedTarget "negative regulation of enzyme activity" . [] oboInOwl:hasDbXref "PMID:23708874", "PMID:9751757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043129 ; owl:annotatedTarget "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "beta-Alanine" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043143 ; owl:annotatedTarget "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043143 ; owl:annotatedTarget "regulation of translation by machinery localisation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043143 ; owl:annotatedTarget "translational machinery localization" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043170 ; owl:annotatedTarget "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:mtg_chebi_dec09" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043170 ; owl:annotatedTarget "biopolymer metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043207 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:jl", "NIF_Subcellular:sao593830697", "Wikipedia:Myelin" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043209 ; owl:annotatedTarget "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." . [] oboInOwl:hasDbXref "NIF_Subcellular:nlx_subcell_20090204" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0043209 ; owl:annotatedTarget "astrocyte sheath" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "beta-alanine" . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1279474730" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0043209 ; owl:annotatedTarget "oligodendrocyte myelin sheath" . [] oboInOwl:hasDbXref "GOC:dgh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043217 ; owl:annotatedTarget "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043226 ; owl:annotatedTarget "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043227 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "3-Aminopropionic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043228 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043229 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "3-aminopropanoic acid" . [] oboInOwl:hasDbXref "GOC:jl", "PMID:9914479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043230 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043231 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "H-beta-Ala-OH" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043232 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043233 ; owl:annotatedTarget "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043235 ; owl:annotatedTarget "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "bAla" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043255 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "beta-aminopropionic acid" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043264 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043269 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16958 ; owl:annotatedTarget "omega-aminopropionic acid" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043270 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043271 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:go_curators", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043292 ; owl:annotatedTarget "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." . [] oboInOwl:hasDbXref "ISBN:0781735149", "PMID:12414722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043368 ; owl:annotatedTarget "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043379 ; owl:annotatedTarget "The process in which a newly activated T cell acquires specialized features of a memory T cell." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043379 ; owl:annotatedTarget "memory T cell development" . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043380 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043380 ; owl:annotatedTarget "regulation of memory T cell development" . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043381 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043381 ; owl:annotatedTarget "negative regulation of memory T cell development" . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043382 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043382 ; owl:annotatedTarget "positive regulation of memory T cell development" . [] oboInOwl:hasDbXref "ISBN:0781735149", "PMID:12220932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043384 ; owl:annotatedTarget "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043412 ; owl:annotatedTarget "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043413 ; owl:annotatedTarget "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." . [] oboInOwl:hasDbXref "Wikipedia:Oxyacid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043436 ; owl:annotatedTarget "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043455 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043467 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." . [] oboInOwl:hasDbXref "GOC:mlg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043470 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043473 ; owl:annotatedTarget "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "Beilstein:74376" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043474 ; owl:annotatedTarget "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043474 ; owl:annotatedTarget "pigment metabolic process during pigmentation" . [] oboInOwl:hasDbXref "PMID:12565799", "PMID:15189144", "PMID:16050976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043504 ; owl:annotatedTarget "The process of restoring mitochondrial DNA after damage." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "CAS:635-65-4" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043549 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "CAS:635-65-4" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043555 ; owl:annotatedTarget "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043576 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "Gmelin:411033" . [] oboInOwl:hasDbXref "GOC:jl", "UBERON:0002097" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043588 ; owl:annotatedTarget "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043603 ; owl:annotatedTarget "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043604 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043648 ; owl:annotatedTarget "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." . [] oboInOwl:hasDbXref "EC:1.2.1.59" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043891 ; owl:annotatedTarget "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." . [] oboInOwl:hasDbXref "EC:1.2.1.59" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043891 ; owl:annotatedTarget "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" . [] oboInOwl:hasDbXref "EC:1.2.1.59" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0043891 ; owl:annotatedTarget "triosephosphate dehydrogenase (NAD(P)+)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:12799017" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043903 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:mtg_mpo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043931 ; owl:annotatedTarget "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043931 ; owl:annotatedTarget "ossification involved in skeletal development" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:18442622" . [] oboInOwl:hasDbXref "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0043931 ; owl:annotatedTarget "ossification involved in bone modeling" . [] oboInOwl:hasDbXref "GOC:mtg_mpo", "GO_REF:0000034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043932 ; owl:annotatedTarget "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0043933 ; owl:annotatedTarget "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0043933 ; owl:annotatedTarget "protein complex subunit organisation" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044042 ; owl:annotatedTarget "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:23763371" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044057 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:23768684" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044058 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044060 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:30224965" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044062 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044065 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:8605219" . [] oboInOwl:hasDbXref "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044085 ; owl:annotatedTarget "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044087 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "PMID:9587403" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044089 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." . [] oboInOwl:hasDbXref "GO:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044092 ; owl:annotatedTarget "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "Reaxys:74376" . [] oboInOwl:hasDbXref "GO:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044093 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044237 ; owl:annotatedTarget "The chemical reactions and pathways by which individual cells transform chemical substances." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044237 ; owl:annotatedTarget "intermediary metabolism" . [] oboInOwl:hasDbXref "GOC:go_curators", "http://www.metacyc.org" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044238 ; owl:annotatedTarget "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044248 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044249 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044255 ; owl:annotatedTarget "The chemical reactions and pathways involving lipids, as carried out by individual cells." . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044271 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044272 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:pde", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044281 ; owl:annotatedTarget "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044282 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." . [] oboInOwl:hasDbXref "GOC:curators", "GOC:pde", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044283 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044297 ; owl:annotatedTarget "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "NIF_Subcellular:sao884265541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044307 ; owl:annotatedTarget "A dendrite arising from another dendrite." . [] oboInOwl:hasDbXref "PMID:25431552" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0044307 ; owl:annotatedTarget "secondary dendrite" . [] oboInOwl:hasDbXref "GOC:cc", "PMID:31257129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044403 ; owl:annotatedTarget "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "bilirubin" . [] oboInOwl:hasDbXref "GOC:cc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044419 ; owl:annotatedTarget "Any process evolved to enable an interaction with an organism of a different species." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000079", "PMID:19776033", "PMID:21129373", "ZFIN:dsf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0044458 ; owl:annotatedTarget "nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044703 ; owl:annotatedTarget "A biological process that directly contributes to the process of producing new individuals, involving another organism." . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044706 ; owl:annotatedTarget "A multicellular organism process which involves another multicellular organism of the same or different species." . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044782 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid" . [] oboInOwl:hasDbXref "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0044848 ; owl:annotatedTarget "A distinct period or stage in a biological process or cycle." . [] oboInOwl:hasDbXref "ISBN:0781735149", "PMID:12414722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045058 ; owl:annotatedTarget "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." . [] oboInOwl:hasDbXref "GOC:add", "GOC:ebc", "GOC:mtg_sensu", "GO_REF:0000022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045087 ; owl:annotatedTarget "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045087 ; owl:annotatedTarget "innate immunity" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" . [] oboInOwl:hasDbXref "GOC:ebc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045088 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." . [] oboInOwl:hasDbXref "GOC:ebc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045089 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." . [] oboInOwl:hasDbXref "ISBN:0716731363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045095 ; owl:annotatedTarget "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." . [] oboInOwl:hasDbXref "ISBN:0716731363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045111 ; owl:annotatedTarget "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045124 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045132 ; owl:annotatedTarget "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045136 ; owl:annotatedTarget "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045144 ; owl:annotatedTarget "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045184 ; owl:annotatedTarget "The directed movement of a protein to a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045184 ; owl:annotatedTarget "establishment of protein localisation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "Bilirubin" . [] oboInOwl:hasDbXref "GOC:jl", "ISBN:0192800981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045187 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045190 ; owl:annotatedTarget "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "bilirubin(Z,Z)" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045191 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of isotype switching." . [] oboInOwl:hasDbXref "GOC:aruk", "ISBN:0198506732", "PMID:24619342", "PMID:29383328", "PMID:31998110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045202 ; owl:annotatedTarget "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1506103497" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0045202 ; owl:annotatedTarget "mixed synapse" . [] oboInOwl:hasDbXref "NIF_Subcellular:sao1311109124" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045202 ; owl:annotatedTarget "electrotonic synapse" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045211 ; owl:annotatedTarget "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045229 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045229 ; owl:annotatedTarget "external encapsulating structure organization and biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16990 ; owl:annotatedTarget "bilirubin-IXalpha" . [] oboInOwl:hasDbXref "ISBN:0198547684", "ISBN:0716743663" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045259 ; owl:annotatedTarget "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." . [] oboInOwl:hasDbXref "GOC:mah", "GOC:mtg_sensu", "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045260 ; owl:annotatedTarget "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045321 ; owl:annotatedTarget "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." . [] oboInOwl:hasDbXref "GOC:mah", "PMID:10968780" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045453 ; owl:annotatedTarget "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045577 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of B cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045577 ; owl:annotatedTarget "regulation of B cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045578 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045578 ; owl:annotatedTarget "negative regulation of B cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045579 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of B cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045579 ; owl:annotatedTarget "positive regulation of B cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045580 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045580 ; owl:annotatedTarget "regulation of T cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045581 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045581 ; owl:annotatedTarget "negative regulation of T cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045582 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045582 ; owl:annotatedTarget "positive regulation of T cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045586 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045586 ; owl:annotatedTarget "regulation of gamma-delta T cell development" . [] obo:IAO_0000116 "This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation." ; a owl:Axiom ; owl:annotatedProperty rdfs:range ; owl:annotatedSource obo:RO_0001025 ; owl:annotatedTarget obo:BFO_0000004 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Beilstein:385686" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045587 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045587 ; owl:annotatedTarget "negative regulation of gamma-delta T cell development" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "CAS:144-62-7" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045588 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045588 ; owl:annotatedTarget "positive regulation of gamma-delta T cell development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045595 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "CAS:144-62-7" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045596 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045597 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell differentiation." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "CAS:144-62-7" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045604 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045604 ; owl:annotatedTarget "regulation of hypodermal cell differentiation" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Gmelin:2208" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045605 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045605 ; owl:annotatedTarget "negative regulation of hypodermal cell differentiation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045606 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170031" . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045606 ; owl:annotatedTarget "positive regulation of hypodermal cell differentiation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045616 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "PMID:15587083" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045617 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045618 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045619 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045619 ; owl:annotatedTarget "regulation of lymphocyte development" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Reaxys:385686" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045620 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045620 ; owl:annotatedTarget "negative regulation of lymphocyte development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045621 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045621 ; owl:annotatedTarget "positive regulation of lymphocyte development" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "OXALIC ACID" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045637 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Oxalic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045638 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045639 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "oxalic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045640 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of basophil differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045641 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Ethandisaeure" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045642 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of basophil differentiation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Ethanedioic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045646 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045646 ; owl:annotatedTarget "regulation of RBC differentiation" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045646 ; owl:annotatedTarget "regulation of red blood cell differentiation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045647 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "H2ox" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045647 ; owl:annotatedTarget "negative regulation of RBC differentiation" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045647 ; owl:annotatedTarget "negative regulation of red blood cell differentiation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045648 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045648 ; owl:annotatedTarget "positive regulation of RBC differentiation" . [] oboInOwl:hasDbXref "CL:0000232" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045648 ; owl:annotatedTarget "positive regulation of red blood cell differentiation" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "HOOCCOOH" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045649 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of macrophage differentiation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "Oxalsaeure" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045650 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045651 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16995 ; owl:annotatedTarget "ethane-1,2-dioic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045652 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045653 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045654 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045655 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of monocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045656 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045657 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045670 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of osteoclast differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045671 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "CAS:57-55-6" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045672 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045682 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of epidermis development." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045682 ; owl:annotatedTarget "regulation of hypodermis development" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "CAS:57-55-6" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045683 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045683 ; owl:annotatedTarget "negative regulation of hypodermis development" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "CAS:57-55-6" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045684 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of epidermis development." . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:rk" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045684 ; owl:annotatedTarget "positive regulation of hypodermis development" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045685 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glia cell differentiation." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "Drug_Central:4024" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045686 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PMID:15665701" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045687 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045700 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PMID:16078503" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045701 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045702 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PMID:18346395" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045719 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PMID:18845115" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045721 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045722 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PMID:21616561" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045724 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045724 ; owl:annotatedTarget "positive regulation of flagellum biogenesis" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045725 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "Reaxys:1340498" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045727 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045727 ; owl:annotatedTarget "positive regulation of protein biosynthetic process" . [] oboInOwl:hasDbXref "GOC:curators", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045728 ; owl:annotatedTarget "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "Propane-1,2-diol" . [] oboInOwl:hasDbXref "ISBN:0198506732", "PMID:2537493", "PMID:9013127" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045729 ; owl:annotatedTarget "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045730 ; owl:annotatedTarget "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "propane-1,2-diol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045738 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045739 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of DNA repair." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "propane-1,2-diol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045744 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045745 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "1,2-Propanediol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045759 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "1,2-Propylenglykol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045760 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045763 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "1,2-dihydroxypropane" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045764 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045765 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of angiogenesis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "2-hydroxypropanol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045766 ; owl:annotatedTarget "Any process that activates or increases angiogenesis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "CH3CH(OH)CH2OH" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045778 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045779 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "HOCH2CH(OH)CH3" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045780 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bone resorption." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045785 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell adhesion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "HOCH2CH(OH)Me" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045786 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "MeCH(OH)CH2OH" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045787 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of progression through the cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045787 ; owl:annotatedTarget "positive regulation of progression through cell cycle" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045806 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "PPD" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045807 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of endocytosis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045818 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "Propylene glycol" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045818 ; owl:annotatedTarget "negative regulation of glycogenolysis" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045819 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045819 ; owl:annotatedTarget "positive regulation of glycogenolysis" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "alpha-propyleneglycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045820 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045821 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of glycolysis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "isopropylene glycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045822 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "methyl glycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045823 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of heart contraction." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045824 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "methylethyl glycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045827 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045828 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "methylethylene glycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045829 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_16997 ; owl:annotatedTarget "monopropylene glycol" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045830 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of isotype switching." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045833 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045834 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045835 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17002 ; owl:annotatedTarget "PMID:2474544" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045836 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of meiosis." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17002 ; owl:annotatedTarget "Cholesterol ester" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045839 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045840 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mitosis." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17002 ; owl:annotatedTarget "a cholesterol ester" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045861 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045862 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17002 ; owl:annotatedTarget "cholesterol esters" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045900 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17002 ; owl:annotatedTarget "cholesteryl esters" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045901 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of translational elongation." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045910 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045911 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of DNA recombination." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045912 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045913 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045916 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045916 ; owl:annotatedTarget "negative regulation of complement cascade" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045917 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of complement activation." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045917 ; owl:annotatedTarget "positive regulation of complement cascade" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045920 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045921 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of exocytosis." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045922 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045923 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045926 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "Beilstein:2951361" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045927 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "CAS:131-48-6" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045930 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045930 ; owl:annotatedTarget "negative regulation of progression through mitotic cell cycle" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:go_curators", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045931 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045931 ; owl:annotatedTarget "positive regulation of progression through mitotic cell cycle" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "CAS:131-48-6" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045932 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:14960498" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045933 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of muscle contraction." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045934 ; owl:annotatedTarget "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045934 ; owl:annotatedTarget "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:16209099" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045935 ; owl:annotatedTarget "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0045935 ; owl:annotatedTarget "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:16624269" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045936 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045937 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:18487279" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045938 ; owl:annotatedTarget "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045939 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:19329108" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045940 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:7508418" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045982 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045982 ; owl:annotatedTarget "negative regulation of purine base metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045983 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "PMID:8448384" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045984 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045984 ; owl:annotatedTarget "negative regulation of pyrimidine base metabolic process" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "Reaxys:1398688" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045985 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0045985 ; owl:annotatedTarget "positive regulation of pyrimidine base metabolic process" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045986 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045987 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "N-Acetylneuraminic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045988 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045989 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045992 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0045995 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of embryonic development." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "Aceneuramic acid" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046005 ; owl:annotatedTarget "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046110 ; owl:annotatedTarget "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "Neu5Ac" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046136 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046137 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046148 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046185 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "NeuAc" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046323 ; owl:annotatedTarget "The directed movement of the hexose monosaccharide glucose into a cell or organelle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046323 ; owl:annotatedTarget "glucose uptake" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046324 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046324 ; owl:annotatedTarget "regulation of glucose uptake" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "O-sialic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046325 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046325 ; owl:annotatedTarget "negative regulation of glucose uptake" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[Aad21122h-2x_2-6_5*NCC/3=O]/1/" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046326 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046326 ; owl:annotatedTarget "positive regulation of glucose uptake" . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046364 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046394 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046483 ; owl:annotatedTarget "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." . [] oboInOwl:hasDbXref "GOC:curators", "UBERON:0001836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046541 ; owl:annotatedTarget "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046543 ; owl:annotatedTarget "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046544 ; owl:annotatedTarget "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "aceneuramic acid" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046620 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "acide aceneuramique" . [] oboInOwl:hasDbXref "GOC:bf", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046621 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046622 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046629 ; owl:annotatedTarget "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "acidium aceneuramicum" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046643 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17012 ; owl:annotatedTarget "acido aceneuramico" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046644 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046645 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." . [] oboInOwl:hasDbXref "GOC:mgi_curators", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046649 ; owl:annotatedTarget "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046651 ; owl:annotatedTarget "The expansion of a lymphocyte population by cell division." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046661 ; owl:annotatedTarget "The establishment of the sex of a male organism by physical differentiation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046676 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046717 ; owl:annotatedTarget "The controlled release of acid by a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046849 ; owl:annotatedTarget "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046850 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046851 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046852 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bone remodeling." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046877 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046878 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046879 ; owl:annotatedTarget "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046883 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046885 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046886 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Beilstein:1915950" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046887 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046888 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "CAS:57-83-0" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046889 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046889 ; owl:annotatedTarget "positive regulation of lipogenesis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "CAS:57-83-0" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046890 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0046890 ; owl:annotatedTarget "regulation of lipogenesis" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046903 ; owl:annotatedTarget "The controlled release of a substance by a cell or a tissue." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "CAS:57-83-0" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046907 ; owl:annotatedTarget "The directed movement of substances within a cell." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0046907 ; owl:annotatedTarget "single organism intracellular transport" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046928 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Drug_Central:2279" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046929 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046942 ; owl:annotatedTarget "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046950 ; owl:annotatedTarget "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0046951 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." . [] oboInOwl:hasDbXref "GOC:jid", "ISBN:0582227089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048103 ; owl:annotatedTarget "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:pr", "ISBN:0879694238" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048137 ; owl:annotatedTarget "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Gmelin:708590" . [] oboInOwl:hasDbXref "GOC:jid", "ISBN:0716731363", "PMID:10219233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048193 ; owl:annotatedTarget "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048199 ; owl:annotatedTarget "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048209 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048232 ; owl:annotatedTarget "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "PMID:10438974" . [] oboInOwl:hasDbXref "GOC:jid", "ISBN:978-3-642-58301-8", "PMID:11820818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048240 ; owl:annotatedTarget "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." . [] oboInOwl:hasDbXref "PMID:23180860" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0048240 ; owl:annotatedTarget "sperm activation" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048241 ; owl:annotatedTarget "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048242 ; owl:annotatedTarget "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." . [] oboInOwl:hasDbXref "GOC:ef", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048243 ; owl:annotatedTarget "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048284 ; owl:annotatedTarget "The creation of a single organelle from two or more organelles." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048285 ; owl:annotatedTarget "The creation of two or more organelles by division of one organelle." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048332 ; owl:annotatedTarget "The process in which the anatomical structures of the mesoderm are generated and organized." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "PMID:9506942" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048468 ; owl:annotatedTarget "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0048468 ; owl:annotatedTarget "terminal differentiation" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048469 ; owl:annotatedTarget "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0048469 ; owl:annotatedTarget "functional differentiation" . [] oboInOwl:hasDbXref "GOC:kmv", "GOC:mtg_sensu", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048477 ; owl:annotatedTarget "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." . [] oboInOwl:hasSynonymType go:systematic_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0048477 ; owl:annotatedTarget "ovum development" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048511 ; owl:annotatedTarget "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:go_curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048512 ; owl:annotatedTarget "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Reaxys:1915950" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048513 ; owl:annotatedTarget "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048514 ; owl:annotatedTarget "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048515 ; owl:annotatedTarget "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "PROGESTERONE" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048518 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048519 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Progesterone" . [] oboInOwl:hasDbXref "GOC:jid", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048520 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048521 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "pregn-4-ene-3,20-dione" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048522 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "progesterone" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048523 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048580 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "(S)-4-Pregnene-3,20-dione" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048581 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048582 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "(S)-Pregn-4-en-3,20-dione" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048583 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "(S)-Progesterone" . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048584 ; owl:annotatedTarget "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048585 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048588 ; owl:annotatedTarget "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "17alpha-progesterone" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048589 ; owl:annotatedTarget "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mtg_sensu" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048598 ; owl:annotatedTarget "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0048598 ; owl:annotatedTarget "embryonic anatomical structure morphogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048609 ; owl:annotatedTarget "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "4-Pregnene-3,20-dione" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048638 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of developmental growth." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Agolutin" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048639 ; owl:annotatedTarget "Any process that activates, maintains or increases the rate of developmental growth." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048640 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048646 ; owl:annotatedTarget "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Akrolutin" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0048646 ; owl:annotatedTarget "formation of an anatomical structure involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:nln" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048699 ; owl:annotatedTarget "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:dsf", "GOC:jid", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048705 ; owl:annotatedTarget "The process in which the anatomical structures of the skeleton are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0048705 ; owl:annotatedTarget "skeletal morphogenesis" . [] oboInOwl:hasDbXref "GOC:vp", "PMID:15139015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048709 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Crinone" . [] oboInOwl:hasDbXref "GOC:vp", "PMID:15139015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048713 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." . [] oboInOwl:hasDbXref "GOC:vp", "PMID:15139015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048714 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Delta(4)-pregnene-3,20-dione" . [] oboInOwl:hasDbXref "GOC:vp", "PMID:15139015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048715 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048729 ; owl:annotatedTarget "The process in which the anatomical structures of a tissue are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048731 ; owl:annotatedTarget "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." . [] oboInOwl:hasDbXref "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048732 ; owl:annotatedTarget "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Gelbkoerperhormon" . [] oboInOwl:hasDbXref "GOC:jid", "GOC:rc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048736 ; owl:annotatedTarget "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048754 ; owl:annotatedTarget "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0048754 ; owl:annotatedTarget "tubulogenesis" . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048770 ; owl:annotatedTarget "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." . [] oboInOwl:hasDbXref "GOC:ebc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048771 ; owl:annotatedTarget "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048799 ; owl:annotatedTarget "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "Progesteron" . [] oboInOwl:hasDbXref "GOC:dsf", "PMID:16740480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048845 ; owl:annotatedTarget "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." . [] oboInOwl:hasDbXref "GO_REF:0000021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048856 ; owl:annotatedTarget "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048869 ; owl:annotatedTarget "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:dph", "GOC:isa_complete", "GOC:mlg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048870 ; owl:annotatedTarget "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048871 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048872 ; owl:annotatedTarget "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0048872 ; owl:annotatedTarget "homeostasis of cell number" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048873 ; owl:annotatedTarget "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0048878 ; owl:annotatedTarget "Any biological process involved in the maintenance of an internal steady state of a chemical." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050432 ; owl:annotatedTarget "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "corpus luteum hormone" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050433 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17026 ; owl:annotatedTarget "luteohormone" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050666 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050667 ; owl:annotatedTarget "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050668 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050669 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050670 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050671 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of lymphocyte proliferation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050672 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050687 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0050687 ; owl:annotatedTarget "negative regulation of antiviral response" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050688 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050708 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050709 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "Beilstein:1723530" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050714 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050727 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "CAS:56-84-8" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050728 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "CAS:56-84-8" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050729 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the inflammatory response." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050764 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "CAS:56-84-8" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050765 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050766 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of phagocytosis." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "Drug_Central:1550" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050767 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "Gmelin:3333" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050768 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050769 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "PMID:11568288" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050776 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050777 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "PMID:21359215" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050778 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050789 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:ebc", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050790 ; owl:annotatedTarget "Any process that modulates the activity of an enzyme." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "Reaxys:1723530" . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050793 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050794 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "(2S)-2-aminobutanedioic acid" . [] oboInOwl:hasDbXref "GOC:go_curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050795 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "L-Aspartic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050796 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of insulin." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050801 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050802 ; owl:annotatedTarget "The part of the circadian sleep/wake cycle where the organism is asleep." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "L-aspartic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050804 ; owl:annotatedTarget "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050805 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "(S)-2-aminobutanedioic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050806 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "(S)-2-aminosuccinic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050810 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." . [] oboInOwl:hasDbXref "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050817 ; owl:annotatedTarget "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050818 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "2-Aminosuccinic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050819 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "ASPARTIC ACID" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050820 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of coagulation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050863 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of T cell activation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "Asp" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050864 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of B cell activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050865 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "D" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050866 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17053 ; owl:annotatedTarget "L-Asparaginsaeure" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050867 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050868 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050869 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050870 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of T cell activation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17062 ; owl:annotatedTarget "RCH2NH2" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050871 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of B cell activation." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mtg_cardio" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050877 ; owl:annotatedTarget "A organ system process carried out by any of the organs or tissues of neurological system." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050878 ; owl:annotatedTarget "Any process that modulates the levels of body fluids." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_muscle", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050879 ; owl:annotatedTarget "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050881 ; owl:annotatedTarget "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050882 ; owl:annotatedTarget "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17062 ; owl:annotatedTarget "RCH2NH2" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050884 ; owl:annotatedTarget "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050885 ; owl:annotatedTarget "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." . [] oboInOwl:hasDbXref "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050886 ; owl:annotatedTarget "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." . [] oboInOwl:hasDbXref "ISBN:0721619908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050890 ; owl:annotatedTarget "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050891 ; owl:annotatedTarget "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0050891 ; owl:annotatedTarget "body fluid osmoregulation" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050892 ; owl:annotatedTarget "Any process in which nutrients are taken up from the contents of the intestine." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050896 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17062 ; owl:annotatedTarget "primary aliphatic amines" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050900 ; owl:annotatedTarget "The movement of a leukocyte within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050905 ; owl:annotatedTarget "Any process pertaining to the functions of the nervous and muscular systems of an organism." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050906 ; owl:annotatedTarget "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050907 ; owl:annotatedTarget "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050908 ; owl:annotatedTarget "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050909 ; owl:annotatedTarget "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050910 ; owl:annotatedTarget "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050911 ; owl:annotatedTarget "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050912 ; owl:annotatedTarget "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050920 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050921 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050922 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050953 ; owl:annotatedTarget "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050954 ; owl:annotatedTarget "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "Beilstein:1723805" . [] oboInOwl:hasDbXref "http://www.medterms.com" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050957 ; owl:annotatedTarget "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050962 ; owl:annotatedTarget "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "CAS:2889-31-8" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050966 ; owl:annotatedTarget "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0050966 ; owl:annotatedTarget "mechanical nociception" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050968 ; owl:annotatedTarget "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0050968 ; owl:annotatedTarget "chemical nociception" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "CAS:2889-31-8" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050973 ; owl:annotatedTarget "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050974 ; owl:annotatedTarget "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050975 ; owl:annotatedTarget "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050976 ; owl:annotatedTarget "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0050982 ; owl:annotatedTarget "The series of events by which a mechanical stimulus is received and converted into a molecular signal." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "Reaxys:1723805" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051046 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "2-hydroxyglutaric acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051047 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051048 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "2-hydroxypentanedioic acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051049 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051050 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17084 ; owl:annotatedTarget "alpha-hydroxyglutaric acid" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051051 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015006 ; owl:annotatedTarget "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "Ketone" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051052 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051053 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "ketones" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051054 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051055 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051055 ; owl:annotatedTarget "negative regulation of lipogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "Keton" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051093 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "R-CO-R'" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051094 ; owl:annotatedTarget "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051128 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051128 ; owl:annotatedTarget "regulation of cell organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051128 ; owl:annotatedTarget "regulation of cell organization" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "a ketone" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051128 ; owl:annotatedTarget "regulation of cellular component organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051129 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051129 ; owl:annotatedTarget "negative regulation of cell organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051129 ; owl:annotatedTarget "negative regulation of cellular component organization and biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "cetone" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051130 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051130 ; owl:annotatedTarget "positive regulation of cellular component organization and biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17087 ; owl:annotatedTarget "ketones" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051171 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051171 ; owl:annotatedTarget "regulation of nitrogen metabolic process" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051172 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051172 ; owl:annotatedTarget "negative regulation of nitrogen metabolic process" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "Glycoprotein" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051173 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051173 ; owl:annotatedTarget "positive regulation of nitrogen metabolic process" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "glycoproteins" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051174 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051175 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "Glykoprotein" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051176 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051179 ; owl:annotatedTarget "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051179 ; owl:annotatedTarget "localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051179 ; owl:annotatedTarget "single organism localization" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015007 ; owl:annotatedTarget "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "Glykoproteine" . [] oboInOwl:hasDbXref "GOC:cjm", "PMID:23251424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051216 ; owl:annotatedTarget "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051222 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "a glycoprotein" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051223 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051224 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051234 ; owl:annotatedTarget "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "glicoproteina" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051234 ; owl:annotatedTarget "establishment of localisation" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051239 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "glicoproteinas" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051240 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051241 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "glycoproteine" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051246 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17089 ; owl:annotatedTarget "glycoproteines" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051247 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051248 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051249 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lymphocyte activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051250 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051251 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051276 ; owl:annotatedTarget "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051276 ; owl:annotatedTarget "chromosome organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:di", "GOC:go_curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051301 ; owl:annotatedTarget "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." . [] oboInOwl:hasDbXref "GOC:go_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051302 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." . [] oboInOwl:hasDbXref "GOC:mtg_cell_cycle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051319 ; owl:annotatedTarget "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Beilstein:1719753" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051321 ; owl:annotatedTarget "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." . [] oboInOwl:hasDbXref "GOC:mtg_cell_cycle" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051325 ; owl:annotatedTarget "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051336 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015008 ; owl:annotatedTarget "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "CAS:149-32-6" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051338 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "CAS:149-32-6" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051339 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051340 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "CAS:149-32-6" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051341 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051345 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Gmelin:82499" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051346 ; owl:annotatedTarget "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMCID:PMC9193570" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051347 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051348 ; owl:annotatedTarget "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:12639570" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051349 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051350 ; owl:annotatedTarget "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:163226" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051351 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051352 ; owl:annotatedTarget "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051353 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051354 ; owl:annotatedTarget "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051355 ; owl:annotatedTarget "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051355 ; owl:annotatedTarget "proprioception during equilibrioception" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051356 ; owl:annotatedTarget "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051356 ; owl:annotatedTarget "visual perception during equilibrioception" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015011 ; owl:annotatedTarget "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:18369603" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051445 ; owl:annotatedTarget "Any process that modulates the rate or extent of progression through the meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051445 ; owl:annotatedTarget "regulation of progression through meiotic cell cycle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:19632091" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051446 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051446 ; owl:annotatedTarget "positive regulation of progression through meiotic cell cycle" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051447 ; owl:annotatedTarget "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051447 ; owl:annotatedTarget "negative regulation of progression through meiotic cell cycle" . [] oboInOwl:hasDbXref "GOC:cjm", "PMID:11027914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051458 ; owl:annotatedTarget "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:19804861" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051458 ; owl:annotatedTarget "adrenocorticotropin secretion" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051459 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051459 ; owl:annotatedTarget "regulation of adrenocorticotropic hormone secretion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051460 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051461 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:23421980" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051461 ; owl:annotatedTarget "positive regulation of adrenocorticotropin secretion" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051493 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051493 ; owl:annotatedTarget "regulation of cytoskeleton organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051493 ; owl:annotatedTarget "regulation of cytoskeleton organization and biogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:23574577" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051494 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051494 ; owl:annotatedTarget "negative regulation of cytoskeleton organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051494 ; owl:annotatedTarget "negative regulation of cytoskeleton organization and biogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:23890177" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051495 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051495 ; owl:annotatedTarget "positive regulation of cytoskeleton organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051495 ; owl:annotatedTarget "positive regulation of cytoskeleton organization and biogenesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051560 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051588 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051589 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051590 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051596 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:35289142" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051604 ; owl:annotatedTarget "Any process leading to the attainment of the full functional capacity of a protein." . [] oboInOwl:hasDbXref "GOC:add", "GOC:ai", "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051606 ; owl:annotatedTarget "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051607 ; owl:annotatedTarget "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051608 ; owl:annotatedTarget "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051640 ; owl:annotatedTarget "Any process in which an organelle is transported to, and/or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051640 ; owl:annotatedTarget "organelle localisation" . [] oboInOwl:hasDbXref "GOC:tb", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051641 ; owl:annotatedTarget "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051641 ; owl:annotatedTarget "cellular localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051641 ; owl:annotatedTarget "single organism cellular localization" . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-6601-2165" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015012 ; owl:annotatedTarget "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:35364613" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051648 ; owl:annotatedTarget "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051648 ; owl:annotatedTarget "vesicle localisation" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dos", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051649 ; owl:annotatedTarget "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051649 ; owl:annotatedTarget "establishment of localisation in cell" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0051649 ; owl:annotatedTarget "establishment of cellular localization" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051650 ; owl:annotatedTarget "The directed movement of a vesicle to a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051650 ; owl:annotatedTarget "establishment of vesicle localisation" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051656 ; owl:annotatedTarget "The directed movement of an organelle to a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051656 ; owl:annotatedTarget "establishment of organelle localisation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:35575772" . [] oboInOwl:hasDbXref "GOC:cc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051702 ; owl:annotatedTarget "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051703 ; owl:annotatedTarget "Any process in which an organism has an effect on an organism of the same species." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051707 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051709 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051709 ; owl:annotatedTarget "regulation of killing of cells of other organism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36276829" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051711 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36354105" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051712 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051716 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051726 ; owl:annotatedTarget "Any process that modulates the rate or extent of progression through the cell cycle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0051726 ; owl:annotatedTarget "arrest of mitotic cell cycle progression" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36478868" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051781 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell division." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36547619" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051782 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051783 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36615861" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051784 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051785 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:36849732" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051873 ; owl:annotatedTarget "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051917 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "PMID:9862657" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051918 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051919 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Reaxys:1735878" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051930 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." . [] oboInOwl:hasDbXref "PMID:19243617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015015 ; owl:annotatedTarget "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Erythritol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051931 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." . [] oboInOwl:hasDbXref "GOC:dos", "ISBN:0126603030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051932 ; owl:annotatedTarget "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." . [] oboInOwl:hasDbXref "GOC:ai", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051937 ; owl:annotatedTarget "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jsg", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051938 ; owl:annotatedTarget "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051938 ; owl:annotatedTarget "L-glutamate uptake" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "erythritol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051952 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051953 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "meso-erythritol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051954 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051955 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "(2R,3S)-butane-1,2,3,4-tetrol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051956 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051956 ; owl:annotatedTarget "negative regulation of amino acid transmembrane transport" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Erythrit" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051957 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051957 ; owl:annotatedTarget "positive regulation of amino acid transmembrane transport" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051960 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Erythrite" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051961 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Erythrol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051962 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051966 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "L-erythritol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051967 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051968 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "MESO-ERYTHRITOL" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051969 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051969 ; owl:annotatedTarget "regulation of conduction of nerve impulse" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Phycite" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051970 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051970 ; owl:annotatedTarget "negative regulation of conduction of nerve impulse" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051971 ; owl:annotatedTarget "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0051971 ; owl:annotatedTarget "positive regulation of conduction of nerve impulse" . [] oboInOwl:hasDbXref "PMID:19243617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0015016 ; owl:annotatedTarget "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "Phycitol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051983 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "erythro-tetritol" . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051984 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." . [] oboInOwl:hasDbXref "GOC:ai" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0051985 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055062 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055064 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17113 ; owl:annotatedTarget "mesoerythritol" . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055067 ; owl:annotatedTarget "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." . [] oboInOwl:hasDbXref "GOC:ai", "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055069 ; owl:annotatedTarget "OBSOLETE. Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." . [] oboInOwl:hasDbXref "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055071 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." . [] oboInOwl:hasDbXref "GOC:ceb", "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055074 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." . [] oboInOwl:hasDbXref "GOC:ceb", "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055080 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:ceb", "GOC:jid", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055081 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom." . [] oboInOwl:hasDbXref "GOC:isa_complete", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055082 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jid" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055085 ; owl:annotatedTarget "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055086 ; owl:annotatedTarget "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." . [] oboInOwl:hasDbXref "GOC:ecd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055117 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." . [] oboInOwl:hasDbXref "GOC:ecd" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055118 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." . [] oboInOwl:hasDbXref "GOC:mh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0055127 ; owl:annotatedTarget "The transmission of vibrations via ossicles to the inner ear." . [] oboInOwl:hasDbXref "GOC:dph", "ISBN:0877797099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060004 ; owl:annotatedTarget "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." . [] oboInOwl:hasDbXref "PMID:11784757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060005 ; owl:annotatedTarget "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060047 ; owl:annotatedTarget "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060048 ; owl:annotatedTarget "Muscle contraction of cardiac muscle tissue." . [] oboInOwl:hasDbXref "GOC:dms", "GOC:dph", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060049 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060049 ; owl:annotatedTarget "regulation of protein amino acid glycosylation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "Beilstein:3601453" . [] oboInOwl:hasDbXref "GOC:dms", "GOC:dph", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060050 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060050 ; owl:annotatedTarget "positive regulation of protein amino acid glycosylation" . [] oboInOwl:hasDbXref "GOC:dms", "GOC:dph", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060051 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060051 ; owl:annotatedTarget "negative regulation of protein amino acid glycosylation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "CAS:151-33-7" . [] oboInOwl:hasDbXref "GOC:dph", "PMID:15039218" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060055 ; owl:annotatedTarget "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060073 ; owl:annotatedTarget "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060078 ; owl:annotatedTarget "Any process that modulates the potential difference across a post-synaptic membrane." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:ef" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060079 ; owl:annotatedTarget "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "Gmelin:326340" . [] oboInOwl:hasDbXref "GOC:dph", "PMID:2913208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060082 ; owl:annotatedTarget "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." . [] oboInOwl:hasDbXref "GOC:dph", "PMID:15827347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060083 ; owl:annotatedTarget "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060083 ; owl:annotatedTarget "urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "hexanoate" . [] oboInOwl:hasDbXref "GOC:dph", "PMID:15827347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060084 ; owl:annotatedTarget "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." . [] oboInOwl:hasDbXref "GOC:dos", "GOC:pdt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060089 ; owl:annotatedTarget "A compound molecular function in which an effector function is controlled by one or more regulatory components." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "hexanoate" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060123 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060124 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "1-hexanoate" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060125 ; owl:annotatedTarget "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "1-pentacarboxylate" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060136 ; owl:annotatedTarget "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:dph", "GOC:mr", "GOC:st" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060156 ; owl:annotatedTarget "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." . [] oboInOwl:hasDbXref "GOC:dgh", "GOC:dph", "PMID:11487378" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060173 ; owl:annotatedTarget "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0060173 ; owl:annotatedTarget "limb bud development" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060249 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060249 ; owl:annotatedTarget "anatomical structure maintenance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "1-pentanecarboxylate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060255 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060259 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "CH3-[CH2]4-COO(-)" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060259 ; owl:annotatedTarget "regulation of feeding behaviour" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060263 ; owl:annotatedTarget "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "butylacetate" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:rl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060264 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060265 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "caproate" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060266 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "capronate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060267 ; owl:annotatedTarget "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060268 ; owl:annotatedTarget "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "hexoate" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:cilia", "GOC:dph", "GOC:kmv", "GOC:pr", "GOC:vw", "ISBN:0198506732", "PMID:13978319", "PMID:27350441", "Reactome:R-HSA-5617833.2" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060271 ; owl:annotatedTarget "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060271 ; owl:annotatedTarget "cilium biogenesis" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060271 ; owl:annotatedTarget "cilium organization" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "hexylate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060284 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:dgh", "GOC:dph", "GOC:krc", "GOC:mlg", "GOC:mtg_cambridge_2013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060285 ; owl:annotatedTarget "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060294 ; owl:annotatedTarget "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "n-caproate" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060295 ; owl:annotatedTarget "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060326 ; owl:annotatedTarget "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "n-hexanoate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060341 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060341 ; owl:annotatedTarget "regulation of cellular localisation" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060343 ; owl:annotatedTarget "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060343 ; owl:annotatedTarget "trabeculation" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060343 ; owl:annotatedTarget "trabecula biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "n-hexoate" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060348 ; owl:annotatedTarget "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060349 ; owl:annotatedTarget "The process in which bones are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph", "PMID:11680679" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060350 ; owl:annotatedTarget "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "n-hexylate" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060351 ; owl:annotatedTarget "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060374 ; owl:annotatedTarget "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060375 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "nPnCO2 anion" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060376 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060377 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "pentanecarboxylate" . [] oboInOwl:hasDbXref "GOC:add", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060405 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17120 ; owl:annotatedTarget "pentylformate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060406 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060407 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060425 ; owl:annotatedTarget "The process in which the anatomical structures of the lung are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060429 ; owl:annotatedTarget "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060441 ; owl:annotatedTarget "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060441 ; owl:annotatedTarget "lung branching morphogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060452 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of cardiac muscle contraction." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060453 ; owl:annotatedTarget "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060454 ; owl:annotatedTarget "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060455 ; owl:annotatedTarget "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060456 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "Beilstein:1866665" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060457 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060462 ; owl:annotatedTarget "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060463 ; owl:annotatedTarget "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "CAS:461-06-3" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060464 ; owl:annotatedTarget "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060467 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:dph", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060474 ; owl:annotatedTarget "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060491 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of cell projection assembly." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060491 ; owl:annotatedTarget "regulation of cell projection formation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "PMID:23868375" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_lung" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060495 ; owl:annotatedTarget "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060495 ; owl:annotatedTarget "cell-cell signalling involved in lung development" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060541 ; owl:annotatedTarget "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "Reaxys:1866665" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060560 ; owl:annotatedTarget "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060560 ; owl:annotatedTarget "differential growth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "3-hydroxy-4-(trimethylammonio)butanoate" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060561 ; owl:annotatedTarget "Any apoptotic process that contributes to the shaping of an anatomical structure." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0060561 ; owl:annotatedTarget "morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060562 ; owl:annotatedTarget "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060606 ; owl:annotatedTarget "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060623 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "carnitine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060627 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17126 ; owl:annotatedTarget "D,L-carnitine" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060632 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060688 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060759 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060760 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060761 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060764 ; owl:annotatedTarget "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0060764 ; owl:annotatedTarget "cell-cell signalling involved in mammary gland development" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060784 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060785 ; owl:annotatedTarget "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060786 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sdb_2009", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060841 ; owl:annotatedTarget "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060916 ; owl:annotatedTarget "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0060986 ; owl:annotatedTarget "The regulated release of a hormone into the circulatory system." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "CAS:15181-46-1" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061007 ; owl:annotatedTarget "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0061007 ; owl:annotatedTarget "hepatobiliary system process" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061024 ; owl:annotatedTarget "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0061024 ; owl:annotatedTarget "membrane organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0061024 ; owl:annotatedTarget "membrane organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061025 ; owl:annotatedTarget "The membrane organization process that joins two lipid bilayers to form a single membrane." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "CAS:15181-46-1" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061035 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061036 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "Gmelin:1455" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061037 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061041 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrogen(trioxidosulfate)(1-)" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061045 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrogensulfite(1-)" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061046 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061047 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrogentrioxosulfate(1-)" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061048 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061116 ; owl:annotatedTarget "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061138 ; owl:annotatedTarget "The process in which the anatomical structures of a branched epithelium are generated and organized." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061383 ; owl:annotatedTarget "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061448 ; owl:annotatedTarget "The progression of a connective tissue over time, from its formation to the mature structure." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061512 ; owl:annotatedTarget "A process in which a protein is transported to, or maintained in, a location within a cilium." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061526 ; owl:annotatedTarget "The regulated release of acetylcholine by a cell." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrogentrioxosulfate(IV)" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061534 ; owl:annotatedTarget "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061535 ; owl:annotatedTarget "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." . [] oboInOwl:hasDbXref "GOC:bhm", "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061695 ; owl:annotatedTarget "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." . [] oboInOwl:hasDbXref "GOC:dph", "PMID:11420129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061696 ; owl:annotatedTarget "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." . [] oboInOwl:hasDbXref "GOC:dph", "PMID:2198020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061727 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." . [] oboInOwl:hasDbXref "PMID:15761415", "PMID:24287494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061844 ; owl:annotatedTarget "An immune response against microbes mediated by anti-microbial peptides in body fluid." . [] oboInOwl:hasDbXref "PMID:29385397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0061983 ; owl:annotatedTarget "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydroxidodioxidosulfate(1-)" . [] oboInOwl:hasDbXref "PMID:29385397" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0061983 ; owl:annotatedTarget "second meiotic division" . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062012 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "monohydrogentrioxosulfate" . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062013 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." . [] oboInOwl:hasDbXref "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062014 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:rph", "PMID:21123617" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062023 ; owl:annotatedTarget "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "Bisulfite" . [] oboInOwl:hasDbXref "PMID:12773390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062033 ; owl:annotatedTarget "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "HSO3(-)" . [] oboInOwl:hasDbXref "PMID:28285835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062125 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." . [] oboInOwl:hasDbXref "PMID:19837031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0062149 ; owl:annotatedTarget "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete", "GOC:mah", "GOC:pr", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0065007 ; owl:annotatedTarget "Any process that modulates a measurable attribute of any biological process, quality or function." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:isa_complete", "GOC:mah", "GOC:pr", "GOC:vw" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0065008 ; owl:annotatedTarget "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "HSO3-" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0065009 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "Hydrogen sulfite" . [] oboInOwl:hasDbXref "GOC:isa_complete" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0065010 ; owl:annotatedTarget "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070013 ; owl:annotatedTarget "An organelle lumen that is part of an intracellular organelle." . [] oboInOwl:hasDbXref "GOC:hjd", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070085 ; owl:annotatedTarget "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070091 ; owl:annotatedTarget "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "[SO2(OH)](-)" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070092 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "bisulfite" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070093 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070094 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "bisulphite" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070125 ; owl:annotatedTarget "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070125 ; owl:annotatedTarget "mitochondrial translation elongation" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrogen sulfite(1-)" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070129 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070129 ; owl:annotatedTarget "regulation of mitochondrial protein anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070129 ; owl:annotatedTarget "regulation of mitochondrial protein biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070129 ; owl:annotatedTarget "regulation of mitochondrial protein formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070129 ; owl:annotatedTarget "regulation of mitochondrial protein synthesis" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17137 ; owl:annotatedTarget "hydrosulfite anion" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070130 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070130 ; owl:annotatedTarget "negative regulation of mitochondrial protein anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070130 ; owl:annotatedTarget "negative regulation of mitochondrial protein biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070130 ; owl:annotatedTarget "negative regulation of mitochondrial protein formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070130 ; owl:annotatedTarget "negative regulation of mitochondrial protein synthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070131 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070131 ; owl:annotatedTarget "positive regulation of mitochondrial protein anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070131 ; owl:annotatedTarget "positive regulation of mitochondrial protein biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070131 ; owl:annotatedTarget "positive regulation of mitochondrial protein formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070131 ; owl:annotatedTarget "positive regulation of mitochondrial protein synthesis" . [] oboInOwl:hasDbXref "ISBN:0815332181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070161 ; owl:annotatedTarget "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070161 ; owl:annotatedTarget "anchoring cell junction" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah", "GOC:sl", "PMID:10206335", "PMID:16931858", "PMID:21196346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070166 ; owl:annotatedTarget "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." . [] oboInOwl:hasDbXref "PMID:16931858" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0070166 ; owl:annotatedTarget "enamel formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070167 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070168 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070169 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070170 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070171 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070172 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070173 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070174 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070175 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070192 ; owl:annotatedTarget "A process of chromosome organization that is involved in a meiotic cell cycle." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070192 ; owl:annotatedTarget "chromosome organisation involved in meiosis" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Beilstein:1720523" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070192 ; owl:annotatedTarget "meiotic chromosome organization" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070201 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070201 ; owl:annotatedTarget "regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "CL:0000542", "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070227 ; owl:annotatedTarget "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "CAS:87-99-0" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070228 ; owl:annotatedTarget "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "CAS:87-99-0" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070229 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070229 ; owl:annotatedTarget "down regulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070229 ; owl:annotatedTarget "down-regulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070229 ; owl:annotatedTarget "downregulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070229 ; owl:annotatedTarget "inhibition of lymphocyte apoptosis" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "CAS:87-99-0" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "up regulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "up-regulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "upregulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "activation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070230 ; owl:annotatedTarget "stimulation of lymphocyte apoptosis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070253 ; owl:annotatedTarget "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:068340007X", "ISBN:0721662544" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070254 ; owl:annotatedTarget "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070254 ; owl:annotatedTarget "mucus production" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Drug_Central:4604" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070255 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070255 ; owl:annotatedTarget "regulation of mucus production" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Gmelin:82893" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070256 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070256 ; owl:annotatedTarget "negative regulation of mucus production" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070257 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070257 ; owl:annotatedTarget "positive regulation of mucus production" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:11154411" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070278 ; owl:annotatedTarget "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070278 ; owl:annotatedTarget "ECM constituent secretion" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070278 ; owl:annotatedTarget "ECM secretion" . [] oboInOwl:hasDbXref "GOC:mah", "PMID:19154717" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070288 ; owl:annotatedTarget "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070293 ; owl:annotatedTarget "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070293 ; owl:annotatedTarget "nephron absorption" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070293 ; owl:annotatedTarget "renal reabsorption" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070295 ; owl:annotatedTarget "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070295 ; owl:annotatedTarget "nephron water absorption" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:11163479" . [] oboInOwl:hasDbXref "GOC:dph" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070295 ; owl:annotatedTarget "renal water reabsorption" . [] oboInOwl:hasDbXref "PMID:11526084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070451 ; owl:annotatedTarget "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070451 ; owl:annotatedTarget "non-sensory hair" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070451 ; owl:annotatedTarget "imaginal disc-derived wing hair" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:12061879" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of haem biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of haem biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of heme anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of heme biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of heme formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070453 ; owl:annotatedTarget "regulation of heme synthesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:15377394" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "down regulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "down-regulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "downregulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "negative regulation of haem biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "negative regulation of heme anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "negative regulation of heme biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "negative regulation of heme formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "negative regulation of heme synthesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:16708791" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070454 ; owl:annotatedTarget "inhibition of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "positive regulation of haem biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "positive regulation of heme anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "positive regulation of heme biosynthesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "positive regulation of heme formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "positive regulation of heme synthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "up regulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "up-regulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "upregulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "activation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070455 ; owl:annotatedTarget "stimulation of heme biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah", "ISBN:0198506732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070459 ; owl:annotatedTarget "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." . [] oboInOwl:hasDbXref "GOC:ecd", "GOC:mah", "ISBN:0198547684", "Wikipedia:Respirasome" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070469 ; owl:annotatedTarget "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:17216457" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070469 ; owl:annotatedTarget "membrane electron transport chain" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070507 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070507 ; owl:annotatedTarget "regulation of microtubule cytoskeleton organisation" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070507 ; owl:annotatedTarget "regulation of microtubule dynamics" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:17216458" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:vk" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070527 ; owl:annotatedTarget "The adhesion of one platelet to one or more other platelets via adhesion molecules." . [] oboInOwl:hasDbXref "CL:0000233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070527 ; owl:annotatedTarget "blood platelet aggregation" . [] oboInOwl:hasDbXref "CL:0000233" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0070527 ; owl:annotatedTarget "thrombocyte aggregation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070613 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070661 ; owl:annotatedTarget "The expansion of a leukocyte population by cell division." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070663 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of leukocyte proliferation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070664 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070664 ; owl:annotatedTarget "down regulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070664 ; owl:annotatedTarget "down-regulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070664 ; owl:annotatedTarget "downregulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070664 ; owl:annotatedTarget "inhibition of leukocyte proliferation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:18316079" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "up regulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "up-regulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "upregulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "activation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070665 ; owl:annotatedTarget "stimulation of leukocyte proliferation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070727 ; owl:annotatedTarget "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070727 ; owl:annotatedTarget "cellular macromolecule localisation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:20030329" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070857 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070857 ; owl:annotatedTarget "regulation of bile acid anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070857 ; owl:annotatedTarget "regulation of bile acid biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070857 ; owl:annotatedTarget "regulation of bile acid formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070857 ; owl:annotatedTarget "regulation of bile acid synthesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "down regulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "down-regulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "downregulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "negative regulation of bile acid anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "negative regulation of bile acid biosynthesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:22791282" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "negative regulation of bile acid formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "negative regulation of bile acid synthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070858 ; owl:annotatedTarget "inhibition of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "positive regulation of bile acid anabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23247825" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "positive regulation of bile acid biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "positive regulation of bile acid formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "positive regulation of bile acid synthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "up regulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "up-regulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "upregulation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "activation of bile acid biosynthetic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070859 ; owl:annotatedTarget "stimulation of bile acid biosynthetic process" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23287496" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070873 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070873 ; owl:annotatedTarget "regulation of glycogen metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23338824" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070874 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070874 ; owl:annotatedTarget "negative regulation of glycogen metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070875 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070875 ; owl:annotatedTarget "positive regulation of glycogen metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070887 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23589387" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070925 ; owl:annotatedTarget "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070942 ; owl:annotatedTarget "The directed killing of a target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070942 ; owl:annotatedTarget "neutrophil mediated cell killing" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070943 ; owl:annotatedTarget "The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070944 ; owl:annotatedTarget "The directed killing of a bacterium by a neutrophil." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23597921" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070948 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070948 ; owl:annotatedTarget "regulation of neutrophil mediated cell killing" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070949 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23615861" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070950 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23796483" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "down regulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "down-regulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "downregulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "negative regulation of neutrophil mediated cell killing" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070954 ; owl:annotatedTarget "inhibition of neutrophil mediated cytotoxicity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23916161" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070955 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070955 ; owl:annotatedTarget "down regulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070955 ; owl:annotatedTarget "down-regulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070955 ; owl:annotatedTarget "downregulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070955 ; owl:annotatedTarget "inhibition of neutrophil mediated killing of symbiont cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:23957303" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070956 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070956 ; owl:annotatedTarget "down regulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070956 ; owl:annotatedTarget "down-regulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070956 ; owl:annotatedTarget "downregulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070956 ; owl:annotatedTarget "inhibition of neutrophil mediated killing of bacterium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:24012734" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "positive regulation of neutrophil mediated cell killing" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "up regulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "up-regulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "upregulation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "activation of neutrophil mediated cytotoxicity" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070960 ; owl:annotatedTarget "stimulation of neutrophil mediated cytotoxicity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "up regulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "up-regulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "upregulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "activation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070961 ; owl:annotatedTarget "stimulation of neutrophil mediated killing of symbiont cell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "up regulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "up-regulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "upregulation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "activation of neutrophil mediated killing of bacterium" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0070962 ; owl:annotatedTarget "stimulation of neutrophil mediated killing of bacterium" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Reaxys:1720523" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0070977 ; owl:annotatedTarget "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071310 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071345 ; owl:annotatedTarget "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." . [] oboInOwl:hasDbXref "GOC:rph" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071621 ; owl:annotatedTarget "The movement of a granulocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "(2R,3r,4S)-pentane-1,2,3,4,5-pentol" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071622 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071623 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Xylitol" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071624 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071625 ; owl:annotatedTarget "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071625 ; owl:annotatedTarget "vocalisation behaviour" . [] oboInOwl:hasDbXref "GOC:gvg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071626 ; owl:annotatedTarget "The process of biting and mashing food with the teeth prior to swallowing." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071626 ; owl:annotatedTarget "chewing" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071674 ; owl:annotatedTarget "The movement of a mononuclear cell within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "meso-xylitol" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071675 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071676 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "xylitol" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071676 ; owl:annotatedTarget "down regulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071676 ; owl:annotatedTarget "down-regulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071676 ; owl:annotatedTarget "downregulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071676 ; owl:annotatedTarget "inhibition of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "(2R,3R,4S)-Pentane-1,2,3,4,5-pentaol" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "up regulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "up-regulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "upregulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "activation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071677 ; owl:annotatedTarget "stimulation of mononuclear cell migration" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071692 ; owl:annotatedTarget "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071692 ; owl:annotatedTarget "protein localisation in extracellular region" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071695 ; owl:annotatedTarget "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071702 ; owl:annotatedTarget "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "D-XYLITOL" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071704 ; owl:annotatedTarget "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071705 ; owl:annotatedTarget "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071707 ; owl:annotatedTarget "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0071707 ; owl:annotatedTarget "immunoglobulin V(D)J joining" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0071707 ; owl:annotatedTarget "immunoglobulin V(D)J recombination" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071707 ; owl:annotatedTarget "immunoglobulin V-D-J joining" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071708 ; owl:annotatedTarget "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0071708 ; owl:annotatedTarget "immunoglobulin V(D)J joining" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_0071708 ; owl:annotatedTarget "immunoglobulin V(D)J recombination" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071708 ; owl:annotatedTarget "immunoglobulin V-J joining" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "L-xylitol" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG1" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG2" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG2a" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG2b" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG2c" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG3" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071735 ; owl:annotatedTarget "IgG4" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG antibody" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "Xylit" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG1 antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG2 antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG2a antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG2b antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG2c antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG3 antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071736 ; owl:annotatedTarget "IgG4 antibody" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:11282392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071738 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:11282392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071739 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071739 ; owl:annotatedTarget "IgD antibody" . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:anteriorly_connected_to ; owl:annotatedTarget "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17151 ; owl:annotatedTarget "xylite" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071742 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071743 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071743 ; owl:annotatedTarget "IgE antibody" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:16362985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071745 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071745 ; owl:annotatedTarget "IgA1 antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071745 ; owl:annotatedTarget "IgA2 antibody" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:16362985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071746 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071746 ; owl:annotatedTarget "IgA antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071746 ; owl:annotatedTarget "IgA1 antibody" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0071746 ; owl:annotatedTarget "IgA2 antibody" . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:20176268" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071753 ; owl:annotatedTarget "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add", "ISBN:0781765196", "PMID:20176268" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071754 ; owl:annotatedTarget "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071754 ; owl:annotatedTarget "IgM antibody" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071824 ; owl:annotatedTarget "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071824 ; owl:annotatedTarget "DNA-protein complex subunit organization" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071824 ; owl:annotatedTarget "protein-DNA complex subunit organisation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071840 ; owl:annotatedTarget "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071840 ; owl:annotatedTarget "cellular component organisation or biogenesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071840 ; owl:annotatedTarget "cellular component organisation or biogenesis at cellular level" . [] oboInOwl:hasDbXref "CL:0000738", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071887 ; owl:annotatedTarget "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." . [] oboInOwl:hasDbXref "GOC:pdt" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071944 ; owl:annotatedTarget "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mah", "PMID:20236620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071953 ; owl:annotatedTarget "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071953 ; owl:annotatedTarget "elastic fibre" . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071953 ; owl:annotatedTarget "elastin fiber" . [] oboInOwl:hasDbXref "GOC:mah", "GOC:tfm", "PMID:19442504", "PMID:27462458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0071971 ; owl:annotatedTarget "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0071971 ; owl:annotatedTarget "extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072175 ; owl:annotatedTarget "The developmental process pertaining to the initial formation of an epithelial tube." . [] oboInOwl:hasDbXref "GOC:mtg_kidney_jan10" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072201 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072330 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072330 ; owl:annotatedTarget "monocarboxylic acid anabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072330 ; owl:annotatedTarget "monocarboxylic acid biosynthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072330 ; owl:annotatedTarget "monocarboxylic acid formation" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072330 ; owl:annotatedTarget "monocarboxylic acid synthesis" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072350 ; owl:annotatedTarget "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072350 ; owl:annotatedTarget "tricarboxylic acid metabolism" . [] oboInOwl:hasDbXref "GOC:mah", "UBERON:0001009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072359 ; owl:annotatedTarget "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "GOC:pde" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072376 ; owl:annotatedTarget "A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events." . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072376 ; owl:annotatedTarget "protein activation pathway" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072376 ; owl:annotatedTarget "protein activitory cascade" . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "GOC:pde", "PMID:1931959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072377 ; owl:annotatedTarget "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." . [] oboInOwl:hasDbXref "GOC:add", "GOC:mah", "GOC:pde" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072378 ; owl:annotatedTarget "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072507 ; owl:annotatedTarget "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072521 ; owl:annotatedTarget "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072521 ; owl:annotatedTarget "purine-containing compound metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072527 ; owl:annotatedTarget "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072527 ; owl:annotatedTarget "pyrimidine-containing compound metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0072593 ; owl:annotatedTarget "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." . [] oboInOwl:hasDbXref "CHEBI:26523", "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072593 ; owl:annotatedTarget "ROS metabolic process" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0072593 ; owl:annotatedTarget "reactive oxygen species metabolism" . [] oboInOwl:hasDbXref "PMID:19211694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0080090 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." . [] oboInOwl:hasDbXref "GOC:dhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0080134 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." . [] oboInOwl:hasDbXref "GOC:dhl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0080135 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." . [] oboInOwl:hasDbXref "GOC:DHL", "PMID:20478994" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0080154 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "PMID:17376402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0086103 ; owl:annotatedTarget "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0086103 ; owl:annotatedTarget "G-protein coupled receptor signaling pathway involved in heart process" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0086103 ; owl:annotatedTarget "G-protein coupled receptor signalling pathway involved in heart process" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0086103 ; owl:annotatedTarget "GPCR signaling pathway involved in cardiac process" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0086103 ; owl:annotatedTarget "GPCR signaling pathway involved in heart process" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090022 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:distally_connected_to ; owl:annotatedTarget "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090023 ; owl:annotatedTarget "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090024 ; owl:annotatedTarget "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090025 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Beilstein:1723527" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090026 ; owl:annotatedTarget "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090027 ; owl:annotatedTarget "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090030 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "CAS:70-47-3" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090031 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090032 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090068 ; owl:annotatedTarget "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "CAS:70-47-3" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090087 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "GOC:ascb_2009", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090139 ; owl:annotatedTarget "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "CAS:70-47-3" . [] oboInOwl:hasDbXref "GOC:ascb_2009", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090174 ; owl:annotatedTarget "The joining of two lipid bilayers to form a single organelle membrane." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090181 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Drug_Central:4126" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090205 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:sl", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090206 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Gmelin:3334" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090257 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:12142634" . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090273 ; owl:annotatedTarget "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090274 ; owl:annotatedTarget "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:15907185" . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090275 ; owl:annotatedTarget "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090276 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." . [] oboInOwl:hasDbXref "https://orcid.org/0000-0002-7073-9172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:extends_fibers_into ; owl:annotatedTarget "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:16190636" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090277 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:16368161" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090278 ; owl:annotatedTarget "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090303 ; owl:annotatedTarget "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090304 ; owl:annotatedTarget "Any cellular metabolic process involving nucleic acids." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:16668324" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090316 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090317 ; owl:annotatedTarget "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:17497286" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090322 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0090322 ; owl:annotatedTarget "regulation of superoxide metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:21800258" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:kmv", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090325 ; owl:annotatedTarget "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." . [] oboInOwl:hasDbXref "GOC:dph", "GOC:kmv", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090326 ; owl:annotatedTarget "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:21854356" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:kmv", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090327 ; owl:annotatedTarget "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "PMID:22513289" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090330 ; owl:annotatedTarget "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090331 ; owl:annotatedTarget "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." . [] oboInOwl:hasDbXref "GOC:dph", "PMID:12871378" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0090331 ; owl:annotatedTarget "platelet disaggregation" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Reaxys:1723527" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090357 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0090357 ; owl:annotatedTarget "regulation of tryptophan metabolism" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "L-Asparagine" . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090358 ; owl:annotatedTarget "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." . [] oboInOwl:hasDbXref "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0090358 ; owl:annotatedTarget "positive regulation of tryptophan metabolism" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:jp", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090368 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "L-asparagine" . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090394 ; owl:annotatedTarget "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0090394 ; owl:annotatedTarget "reduction of excitatory postsynaptic membrane potential" . [] oboInOwl:hasDbXref "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090594 ; owl:annotatedTarget "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." . [] oboInOwl:hasDbXref "GOC:add", "PMID:26086132", "PMID:26831526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090713 ; owl:annotatedTarget "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." . [] oboInOwl:hasDbXref "GOC:add", "PMID:26086132", "PMID:26831526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0090715 ; owl:annotatedTarget "Any immunological memory process that can contribute to the formation of immunological memory." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "(2S)-2,4-diamino-4-oxobutanoic acid" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:cilia", "GOC:dos", "PMID:17895364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097014 ; owl:annotatedTarget "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." . [] oboInOwl:hasDbXref "CL:0000451", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097028 ; owl:annotatedTarget "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "(2S)-2-amino-3-carbamoylpropanoic acid" . [] oboInOwl:hasDbXref "GOC:BHF", "PMID:20410104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097060 ; owl:annotatedTarget "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:sl", "PMID:10206335", "PMID:21196346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097186 ; owl:annotatedTarget "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." . [] oboInOwl:hasDbXref "GOC:mtg_apoptosis", "PMID:21760595" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097194 ; owl:annotatedTarget "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." . [] oboInOwl:hasDbXref "GOC:pr", "GOC:sart" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097205 ; owl:annotatedTarget "A renal system process in which fluid circulating through the body is filtered through a barrier system." . [] oboInOwl:hasDbXref "GOC:rph", "PMID:25287933", "Wikipedia:Renal_secretion#Secretion" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097254 ; owl:annotatedTarget "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "(S)-2-amino-3-carbamoylpropanoic acid" . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "NIF_Subcellular:sao172297168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097447 ; owl:annotatedTarget "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." . [] oboInOwl:hasDbXref "GOC:cvs", "PMID:22342843", "PMID:24157461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097529 ; owl:annotatedTarget "The movement of a myeloid leukocyte within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "GOC:cvs", "PMID:24163421", "PMID:24193336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097530 ; owl:annotatedTarget "The movement of a granulocyte within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097708 ; owl:annotatedTarget "Any vesicle that is part of the intracellular region." . [] oboInOwl:hasDbXref "GOC:cilia", "PMID:20106869", "PMID:23351793", "PMID:24814148", "PMID:26485645", "Reactome:R-HSA-5620920.1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097712 ; owl:annotatedTarget "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "(S)-Asparagine" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097722 ; owl:annotatedTarget "Any process involved in the controlled movement of a sperm cell." . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:bf", "PMID:19442504", "PMID:25392495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0097734 ; owl:annotatedTarget "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098542 ; owl:annotatedTarget "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098588 ; owl:annotatedTarget "The lipid bilayer that forms the outer-most layer of an organelle." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098590 ; owl:annotatedTarget "A membrane that is a (regional) part of the plasma membrane." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "2-Aminosuccinamic acid" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098609 ; owl:annotatedTarget "The attachment of one cell to another cell via adhesion molecules." . [] oboInOwl:hasDbXref "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098642 ; owl:annotatedTarget "A collagen trimer that forms networks." . [] oboInOwl:hasDbXref "GOC:dos", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098643 ; owl:annotatedTarget "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "ASPARAGINE" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098644 ; owl:annotatedTarget "A complex of collagen trimers such as a fibril or collagen network." . [] oboInOwl:hasDbXref "PMID:19693541" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0098644 ; owl:annotatedTarget "Supramolecular aggregate of collagen" . [] oboInOwl:hasDbXref "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0098644 ; owl:annotatedTarget "Supramolecular collagen assembly" . [] oboInOwl:hasDbXref "GOC:dos", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098645 ; owl:annotatedTarget "A supramolecular complex that consists of collagen triple helices associated to form a network." . [] oboInOwl:hasDbXref "GOC:dos", "PMID:21421911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098651 ; owl:annotatedTarget "Any collagen timer that is part of a basement membrane." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Asn" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098657 ; owl:annotatedTarget "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098754 ; owl:annotatedTarget "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098771 ; owl:annotatedTarget "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098793 ; owl:annotatedTarget "The part of a synapse that is part of the presynaptic cell." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098794 ; owl:annotatedTarget "The part of a synapse that is part of the post-synaptic cell." . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "Aspartamic acid" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098796 ; owl:annotatedTarget "Any protein complex that is part of a membrane." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098797 ; owl:annotatedTarget "Any protein complex that is part of the plasma membrane." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "L-2-aminosuccinamic acid" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098798 ; owl:annotatedTarget "A protein complex that is part of a mitochondrion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "L-Asparagin" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098800 ; owl:annotatedTarget "Any protein complex that is part of the inner mitochondrial membrane." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098801 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098802 ; owl:annotatedTarget "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "L-aspartic acid beta-amide" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098803 ; owl:annotatedTarget "Any protein complex that is part of a respiratory chain." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098813 ; owl:annotatedTarget "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "N" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098815 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." . [] oboInOwl:hasDbXref "PMID:15661519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098858 ; owl:annotatedTarget "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098871 ; owl:annotatedTarget "The actin cytoskeleton that is part of a postsynapse." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17196 ; owl:annotatedTarget "alpha-aminosuccinamic acid" . [] oboInOwl:hasDbXref "GOC:dos", "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098900 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098916 ; owl:annotatedTarget "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0098976 ; owl:annotatedTarget "Synaptic transmission that results in an excitatory postsynaptic potential." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099003 ; owl:annotatedTarget "Any vesicle-mediated transport that occurs in a synapse." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099080 ; owl:annotatedTarget "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099081 ; owl:annotatedTarget "A polymeric supramolecular structure." . [] oboInOwl:hasDbXref "GOC:cjm", "ISBN:0815316194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099111 ; owl:annotatedTarget "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:bf", "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099123 ; owl:annotatedTarget "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." . [] oboInOwl:hasDbXref "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0099123 ; owl:annotatedTarget "STD DA release" . [] oboInOwl:hasDbXref "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0099123 ; owl:annotatedTarget "STD dopamine release" . [] oboInOwl:hasDbXref "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0099123 ; owl:annotatedTarget "somatodendritic dopamine release" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:bf", "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099124 ; owl:annotatedTarget "The regulated release of dopamine from an axon." . [] oboInOwl:hasDbXref "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0099124 ; owl:annotatedTarget "axonal DA release" . [] oboInOwl:hasDbXref "PMID:21576241" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_0099124 ; owl:annotatedTarget "axonal dopamine release" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099143 ; owl:annotatedTarget "The actin cytoskeleton that is part of a presynapse." . [] oboInOwl:hasDbXref "GOC:dos", "PMID:25869803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099160 ; owl:annotatedTarget "The intermediate filament cytoskeleton that is part of a postsynapse." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099170 ; owl:annotatedTarget "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099171 ; owl:annotatedTarget "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099177 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099182 ; owl:annotatedTarget "The intermediate filament cytoskeleton that is part of a presynapse." . [] oboInOwl:hasDbXref "GOC:aruk", "GOC:bc", "ISBN:0071120009", "PMID:18618940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099500 ; owl:annotatedTarget "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099503 ; owl:annotatedTarget "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099512 ; owl:annotatedTarget "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099513 ; owl:annotatedTarget "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099530 ; owl:annotatedTarget "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099531 ; owl:annotatedTarget "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099536 ; owl:annotatedTarget "Cell-cell signaling to, from or within a synapse." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099537 ; owl:annotatedTarget "Cell-cell signaling in either direction across the synaptic cleft." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099547 ; owl:annotatedTarget "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099550 ; owl:annotatedTarget "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "Beilstein:80810" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099565 ; owl:annotatedTarget "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." . [] oboInOwl:hasSynonymType go:syngo_official_label ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_0099565 ; owl:annotatedTarget "postsynaptic process involved in chemical synaptic transmission" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099568 ; owl:annotatedTarget "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "CAS:147-85-3" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099569 ; owl:annotatedTarget "The portion of the cytoskeleton contained within the presynapse." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "CAS:147-85-3" . [] oboInOwl:hasDbXref "GOC:dos", "PMID:19889835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099571 ; owl:annotatedTarget "The portion of the cytoskeleton contained within the postsynapse." . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099577 ; owl:annotatedTarget "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "CAS:147-85-3" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099578 ; owl:annotatedTarget "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "Drug_Central:4125" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099643 ; owl:annotatedTarget "Any signal release from a synapse." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "Gmelin:50152" . [] oboInOwl:hasDbXref "GOC:dos" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0099738 ; owl:annotatedTarget "The complete extent of cell cortex that underlies some some region of the plasma membrane." . [] oboInOwl:hasDbXref "GOC:cjm", "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0100001 ; owl:annotatedTarget "Any action potential process that regulates skeletal muscle contraction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:11076505" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26022821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106014 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26022821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106015 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:12770004" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26022821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106016 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:14975886" . [] oboInOwl:hasDbXref "PMID:29056341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106064 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." . [] oboInOwl:hasDbXref "PMID:29056341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106121 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:15576824" . [] oboInOwl:hasDbXref "PMID:29056341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0106122 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." . [] oboInOwl:hasDbXref "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0110110 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:15838615" . [] oboInOwl:hasDbXref "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0110111 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." . [] oboInOwl:hasDbXref "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0110165 ; owl:annotatedTarget "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:15894682" . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120025 ; owl:annotatedTarget "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120031 ; owl:annotatedTarget "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." . [] oboInOwl:hasDbXref "GOC:krc", "GOC:rjd", "PMID:10328951", "PMID:9096956" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_0120031 ; owl:annotatedTarget "eupodium" . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120032 ; owl:annotatedTarget "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:15973048" . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120033 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16033917" . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120034 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120035 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120036 ; owl:annotatedTarget "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." . [] oboInOwl:hasDbXref "GOC:sl", "PMID:15890336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120054 ; owl:annotatedTarget "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16190672" . [] oboInOwl:hasDbXref "GOC:ha" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120111 ; owl:annotatedTarget "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." . [] oboInOwl:hasDbXref "GOC:krc", "GOC:nln" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120178 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16501220" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120188 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120189 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:posteriorly_connected_to ; owl:annotatedTarget "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16656443" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120190 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16657874" . [] oboInOwl:hasDbXref "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120305 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." . [] oboInOwl:hasDbXref "GOC:krc", "PMID:32791035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0120316 ; owl:annotatedTarget "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." . [] oboInOwl:hasDbXref "PMID:9334324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140013 ; owl:annotatedTarget "One of the two nuclear divisions that occur as part of the meiotic cell cycle." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:16668324" . [] oboInOwl:hasDbXref "ISBN:0198547684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140014 ; owl:annotatedTarget "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." . [] oboInOwl:hasDbXref "Wikipedia:Exocytosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140029 ; owl:annotatedTarget "The cellular processes that contribute to exocytosis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:17127472" . [] oboInOwl:hasDbXref "PMID:27058308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140053 ; owl:annotatedTarget "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." . [] oboInOwl:hasDbXref "PMID:28736435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140112 ; owl:annotatedTarget "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:17608428" . [] oboInOwl:hasDbXref "PMID:27321671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140236 ; owl:annotatedTarget "Translation that occurs at the presynapse." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:18551589" . [] oboInOwl:hasDbXref "PMID:27321671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140237 ; owl:annotatedTarget "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." . [] oboInOwl:hasDbXref "PMID:24719103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140238 ; owl:annotatedTarget "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:18802692" . [] oboInOwl:hasDbXref "PMID:12839988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140239 ; owl:annotatedTarget "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." . [] oboInOwl:hasDbXref "PMID:23083742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140241 ; owl:annotatedTarget "Translation that occurs at the synapse." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:18973300" . [] oboInOwl:hasDbXref "PMID:20427644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140242 ; owl:annotatedTarget "Translation that occurs at the postsynapse." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:19215998" . [] oboInOwl:hasDbXref "PMID:20427644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140243 ; owl:annotatedTarget "Any process that regulates translation occurring at the synapse." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:19580280" . [] oboInOwl:hasDbXref "PMID:20427644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140244 ; owl:annotatedTarget "Any process that regulates translation occurring at the presynapse." . [] oboInOwl:hasDbXref "PMID:20427644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140245 ; owl:annotatedTarget "Any process that regulates translation occurring at the postsynapse." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140352 ; owl:annotatedTarget "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:proximally_connected_to ; owl:annotatedTarget "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:19656302" . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140353 ; owl:annotatedTarget "The directed movement of a lipid from a cell, into the extracellular region." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140513 ; owl:annotatedTarget "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140546 ; owl:annotatedTarget "Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont." . [] oboInOwl:hasDbXref "GOC:curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0140962 ; owl:annotatedTarget "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0141060 ; owl:annotatedTarget "The disruption of the an anatomical structure of another organism, leading to damage or temporary subversion of that structure." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:19688381" . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_0141061 ; owl:annotatedTarget "The disruption of the a cell of another organism, leading to damage or temporary subversion of that cell." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900015 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900015 ; owl:annotatedTarget "regulation of cytokine production involved in acute inflammatory response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:19811425" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900016 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1900016 ; owl:annotatedTarget "down regulation of cytokine production involved in acute inflammatory response" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900016 ; owl:annotatedTarget "negative regulation of cytokine production involved in acute inflammatory response" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900016 ; owl:annotatedTarget "down regulation of cytokine production involved in inflammatory response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22139509" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900017 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1900017 ; owl:annotatedTarget "up regulation of cytokine production involved in acute inflammatory response" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900017 ; owl:annotatedTarget "positive regulation of cytokine production involved in acute inflammatory response" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900017 ; owl:annotatedTarget "up regulation of cytokine production involved in inflammatory response" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22201772" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900046 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of hemostasis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900047 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900047 ; owl:annotatedTarget "down regulation of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900047 ; owl:annotatedTarget "down-regulation of hemostasis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22451406" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900047 ; owl:annotatedTarget "downregulation of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900047 ; owl:annotatedTarget "inhibition of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900048 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of hemostasis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900048 ; owl:annotatedTarget "up regulation of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900048 ; owl:annotatedTarget "up-regulation of hemostasis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22475019" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900048 ; owl:annotatedTarget "upregulation of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900048 ; owl:annotatedTarget "activation of hemostasis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900073 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22482728" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900074 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900074 ; owl:annotatedTarget "down regulation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900074 ; owl:annotatedTarget "down-regulation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900074 ; owl:annotatedTarget "downregulation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900074 ; owl:annotatedTarget "inhibition of neuromuscular synaptic transmission" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22491679" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900075 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900075 ; owl:annotatedTarget "activation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900075 ; owl:annotatedTarget "up regulation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900075 ; owl:annotatedTarget "up-regulation of neuromuscular synaptic transmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900075 ; owl:annotatedTarget "upregulation of neuromuscular synaptic transmission" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900115 ; owl:annotatedTarget "Any regulation of signal transduction that takes place in the extracellular region." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900115 ; owl:annotatedTarget "regulation of signaling pathway in extracellular region" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900115 ; owl:annotatedTarget "regulation of signalling pathway in extracellular region" . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:transitively_anteriorly_connected_to ; owl:annotatedTarget "." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "Reaxys:80810" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:signaling" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "Any negative regulation of signal transduction that takes place in extracellular region." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "down regulation of signal transduction in extracellular region" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "down-regulation of signal transduction in extracellular region" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "downregulation of signal transduction in extracellular region" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "negative regulation of signaling pathway in extracellular region" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "negative regulation of signalling pathway in extracellular region" . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "extracellular inhibition of signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900116 ; owl:annotatedTarget "inhibition of signal transduction in extracellular region" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-Proline" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900117 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900118 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-proline" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900118 ; owl:annotatedTarget "down regulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900118 ; owl:annotatedTarget "down-regulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900118 ; owl:annotatedTarget "downregulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900118 ; owl:annotatedTarget "inhibition of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900119 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(-)-(S)-proline" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900119 ; owl:annotatedTarget "up regulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900119 ; owl:annotatedTarget "up-regulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900119 ; owl:annotatedTarget "upregulation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900119 ; owl:annotatedTarget "activation of execution phase of apoptosis" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900157 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(-)-2-pyrrolidinecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900158 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900158 ; owl:annotatedTarget "down regulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900158 ; owl:annotatedTarget "down-regulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900158 ; owl:annotatedTarget "downregulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900158 ; owl:annotatedTarget "inhibition of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(-)-proline" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900159 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900159 ; owl:annotatedTarget "up regulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900159 ; owl:annotatedTarget "up-regulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900159 ; owl:annotatedTarget "upregulation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900159 ; owl:annotatedTarget "activation of bone mineralization involved in bone maturation" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(2S)-pyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:22346749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of defense response to bacterium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defence response to bacterium, incompatible interaction" . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(S)-2-carboxypyrrolidine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defence response to pathogenic bacteria, incompatible interaction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of defence response to pathogenic bacterium, incompatible interaction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of resistance response to pathogenic bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of resistance response to pathogenic bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900424 ; owl:annotatedTarget "regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(S)-2-pyrrolidinecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:22346749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down regulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down-regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down-regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down-regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down-regulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "downregulation of defence response to bacteria" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "(S)-pyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "downregulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "downregulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "downregulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "negative regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "negative regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "negative regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defence response to pathogenic bacteria, incompatible interaction" . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:transitively_distally_connected_to ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "2-Pyrrolidinecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defence response to pathogenic bacterium, incompatible interaction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of defense response to bacterium, incompatible interaction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of resistance response to pathogenic bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of resistance response to pathogenic bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of response to pathogenic bacteria (incompatible interaction)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of response to pathogenic bacterium (incompatible interaction)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "down-regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "downregulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-(-)-proline" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "inhibition of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900425 ; owl:annotatedTarget "negative regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:22346749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of defence response to bacterium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-Prolin" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "positive regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "positive regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "positive regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up regulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up-regulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up-regulation of defence response to bacterium" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-alpha-pyrrolidinecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up-regulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up-regulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "upregulation of defence response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "upregulation of defence response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "upregulation of defense response to bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "upregulation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of defense response to bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of resistance response to pathogenic bacteria" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of resistance response to pathogenic bacterium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "activation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "L-pyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "positive regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "up-regulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1900426 ; owl:annotatedTarget "upregulation of antibacterial peptide activity" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:yaf", "PMID:17951379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901052 ; owl:annotatedTarget "The chemical reactions and pathways involving sarcosine." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901052 ; owl:annotatedTarget "sarcosine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901135 ; owl:annotatedTarget "The chemical reactions and pathways involving carbohydrate derivative." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901135 ; owl:annotatedTarget "carbohydrate derivative metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901137 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901137 ; owl:annotatedTarget "carbohydrate derivative anabolism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "P" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901137 ; owl:annotatedTarget "carbohydrate derivative biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901137 ; owl:annotatedTarget "carbohydrate derivative formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901137 ; owl:annotatedTarget "carbohydrate derivative synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pg", "PMID:18668558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901148 ; owl:annotatedTarget "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." . [] oboInOwl:hasDbXref "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901148 ; owl:annotatedTarget "expression of extracellular matrix proteins" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "PROLINE" . [] oboInOwl:hasDbXref "GOC:pg" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901148 ; owl:annotatedTarget "extracellular matrix protein production" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901317 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of flagellated sperm motility." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901317 ; owl:annotatedTarget "regulation of sperm movement" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "prolina" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "down regulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "down regulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "down-regulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "down-regulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "downregulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "downregulation of sperm movement" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "proline" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "inhibition of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "negative regulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901318 ; owl:annotatedTarget "inhibition of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901334 ; owl:annotatedTarget "The chemical reactions and pathways involving lactone." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901334 ; owl:annotatedTarget "lactone metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17203 ; owl:annotatedTarget "prolinum" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901342 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of vasculature development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901342 ; owl:annotatedTarget "regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "down regulation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "down-regulation of vasculature development" . [] oboInOwl:hasDbXref "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource core:transitively_proximally_connected_to ; owl:annotatedTarget "." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_1722 ; owl:annotatedTarget "3beta-hydroxy Delta(5)-steroids" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "downregulation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "inhibition of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "down regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "down-regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "downregulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "inhibition of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901343 ; owl:annotatedTarget "negative regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901360 ; owl:annotatedTarget "The chemical reactions and pathways involving organic cyclic compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901360 ; owl:annotatedTarget "organic cyclic compound metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901362 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of organic cyclic compound." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_1722 ; owl:annotatedTarget "3beta-hydroxy-Delta(5)-steroids" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901362 ; owl:annotatedTarget "organic cyclic compound anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901362 ; owl:annotatedTarget "organic cyclic compound biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901362 ; owl:annotatedTarget "organic cyclic compound formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901362 ; owl:annotatedTarget "organic cyclic compound synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901374 ; owl:annotatedTarget "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_1722 ; owl:annotatedTarget "a 3beta-hydroxy-Delta(5)-steroid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mengo_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901401 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901401 ; owl:annotatedTarget "regulation of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mengo_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "down regulation of tetrapyrrole metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "down regulation of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "down-regulation of tetrapyrrole metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "down-regulation of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "downregulation of tetrapyrrole metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "downregulation of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "inhibition of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "negative regulation of tetrapyrrole metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901402 ; owl:annotatedTarget "inhibition of tetrapyrrole metabolic process" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17234 ; owl:annotatedTarget "CAS:50-99-7" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901463 ; owl:annotatedTarget "regulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901463 ; owl:annotatedTarget "regulation of tetrapyrrole biosynthesis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17234 ; owl:annotatedTarget "gluco-hexose" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901463 ; owl:annotatedTarget "regulation of tetrapyrrole formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901463 ; owl:annotatedTarget "regulation of tetrapyrrole synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mengo_curators" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down regulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down regulation of tetrapyrrole biosynthesis" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down-regulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down-regulation of tetrapyrrole biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down-regulation of tetrapyrrole biosynthetic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down-regulation of tetrapyrrole formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "down-regulation of tetrapyrrole synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "downregulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "downregulation of tetrapyrrole biosynthesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17234 ; owl:annotatedTarget "DL-glucose" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "downregulation of tetrapyrrole biosynthetic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "downregulation of tetrapyrrole formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "downregulation of tetrapyrrole synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "inhibition of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "inhibition of tetrapyrrole biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "inhibition of tetrapyrrole formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "inhibition of tetrapyrrole synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "negative regulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "negative regulation of tetrapyrrole biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "negative regulation of tetrapyrrole formation" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17234 ; owl:annotatedTarget "Glc" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901464 ; owl:annotatedTarget "negative regulation of tetrapyrrole synthesis" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901465 ; owl:annotatedTarget "positive regulation of tetrapyrrole formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901465 ; owl:annotatedTarget "positive regulation of tetrapyrrole synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901465 ; owl:annotatedTarget "up regulation of tetrapyrrole anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901465 ; owl:annotatedTarget "up regulation of tetrapyrrole biosynthesis" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901495 ; owl:annotatedTarget "down-regulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901495 ; owl:annotatedTarget "downregulation of cysteine metabolic process" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17258 ; owl:annotatedTarget "Beilstein:3200" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901495 ; owl:annotatedTarget "downregulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901495 ; owl:annotatedTarget "negative regulation of cysteine metabolism" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "positive regulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "up regulation of cysteine metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "up regulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "up-regulation of cysteine metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "up-regulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "upregulation of cysteine metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "upregulation of cysteine metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "activation of cysteine metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901496 ; owl:annotatedTarget "activation of cysteine metabolism" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17258 ; owl:annotatedTarget "Reaxys:3200" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901532 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901532 ; owl:annotatedTarget "regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901532 ; owl:annotatedTarget "regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17258 ; owl:annotatedTarget "7H-purine" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down regulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down-regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down-regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down-regulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "downregulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17258 ; owl:annotatedTarget "Purine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "downregulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "downregulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "inhibition of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "inhibition of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "negative regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "negative regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "inhibition of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down regulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "down-regulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "downregulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17258 ; owl:annotatedTarget "Purine base" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901533 ; owl:annotatedTarget "inhibition of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "activation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "activation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "positive regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "positive regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up regulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up-regulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up-regulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up-regulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "upregulation of haematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "upregulation of haemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "upregulation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "activation of hemopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "activation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up regulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "up-regulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901534 ; owl:annotatedTarget "upregulation of hematopoietic progenitor cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901564 ; owl:annotatedTarget "The chemical reactions and pathways involving organonitrogen compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901564 ; owl:annotatedTarget "organonitrogen compound metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901566 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of organonitrogen compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901566 ; owl:annotatedTarget "organonitrogen compound anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901566 ; owl:annotatedTarget "organonitrogen compound biosynthesis" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "Beilstein:3587503" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901566 ; owl:annotatedTarget "organonitrogen compound formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901566 ; owl:annotatedTarget "organonitrogen compound synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901568 ; owl:annotatedTarget "The chemical reactions and pathways involving fatty acid derivative." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901568 ; owl:annotatedTarget "fatty acid derivative metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901570 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of fatty acid derivative." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901570 ; owl:annotatedTarget "fatty acid derivative anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901570 ; owl:annotatedTarget "fatty acid derivative biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901570 ; owl:annotatedTarget "fatty acid derivative formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901570 ; owl:annotatedTarget "fatty acid derivative synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901575 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "CAS:72-03-7" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901575 ; owl:annotatedTarget "organic molecular entity breakdown" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901575 ; owl:annotatedTarget "organic molecular entity catabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901575 ; owl:annotatedTarget "organic molecular entity degradation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901576 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901576 ; owl:annotatedTarget "organic molecular entity anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901576 ; owl:annotatedTarget "organic molecular entity biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901576 ; owl:annotatedTarget "organic molecular entity formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901576 ; owl:annotatedTarget "organic molecular entity synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901605 ; owl:annotatedTarget "The chemical reactions and pathways involving an alpha-amino acid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901605 ; owl:annotatedTarget "alpha-amino acid metabolism" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "CAS:72-03-7" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901615 ; owl:annotatedTarget "The chemical reactions and pathways involving organic hydroxy compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901615 ; owl:annotatedTarget "organic hydroxy compound metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901617 ; owl:annotatedTarget "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901617 ; owl:annotatedTarget "organic hydroxy compound anabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901617 ; owl:annotatedTarget "organic hydroxy compound biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901617 ; owl:annotatedTarget "organic hydroxy compound formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901617 ; owl:annotatedTarget "organic hydroxy compound synthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901657 ; owl:annotatedTarget "The chemical reactions and pathways involving glycosyl compound." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901657 ; owl:annotatedTarget "glycosyl compound metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:go_curators", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901661 ; owl:annotatedTarget "The chemical reactions and pathways involving quinone." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "Gmelin:1820" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901661 ; owl:annotatedTarget "quinone metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901702 ; owl:annotatedTarget "Enables the transfer of salt from one side of a membrane to the other." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:fj" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "positive regulation of blood platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up regulation of blood platelet aggregation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "PMID:17951291" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up regulation of platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up-regulation of blood platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up-regulation of platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "upregulation of blood platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "upregulation of platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "activation of blood platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "activation of platelet aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "activation of thrombocyte aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "positive regulation of thrombocyte aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up regulation of thrombocyte aggregation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "PMID:18375549" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "up-regulation of thrombocyte aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1901731 ; owl:annotatedTarget "upregulation of thrombocyte aggregation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:18093975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901738 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901738 ; owl:annotatedTarget "regulation of vitamin A metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "PMID:2647392" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901858 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901858 ; owl:annotatedTarget "regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901858 ; owl:annotatedTarget "regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901858 ; owl:annotatedTarget "regulation of mtDNA metabolism" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "UM-BBD_compID:c0277" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down regulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down-regulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down-regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "propanoate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down-regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "down-regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "downregulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "downregulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "downregulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "downregulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "inhibition of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "inhibition of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "inhibition of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "negative regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "propionate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "negative regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "negative regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901859 ; owl:annotatedTarget "inhibition of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "activation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "CH3-CH2-COO(-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "activation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "activation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "positive regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "positive regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "positive regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up regulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up-regulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "EtCO2 anion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up-regulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up-regulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "up-regulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "upregulation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "upregulation of mitochondrial DNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "upregulation of mtDNA metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "upregulation of mtDNA metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1901860 ; owl:annotatedTarget "activation of mitochondrial DNA metabolic process" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "carboxylatoethane" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902017 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cilium assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902017 ; owl:annotatedTarget "regulation of ciliogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902017 ; owl:annotatedTarget "regulation of cilium biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "ethanecarboxylate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down regulation of ciliogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down regulation of cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down-regulation of ciliogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down-regulation of cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "downregulation of ciliogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "downregulation of cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "inhibition of ciliogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "negative regulation of ciliogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "ethylformate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "inhibition of cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down regulation of cilium biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "down-regulation of cilium biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "downregulation of cilium biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "inhibition of cilium biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902018 ; owl:annotatedTarget "negative regulation of cilium biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "metacetonate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902019 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902020 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902020 ; owl:annotatedTarget "down regulation of ciliary cell motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902020 ; owl:annotatedTarget "down-regulation of ciliary cell motility" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "methylacetate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902020 ; owl:annotatedTarget "downregulation of ciliary cell motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902020 ; owl:annotatedTarget "inhibition of ciliary cell motility" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:jh2", "GOC:krc", "PMID:7513657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "activation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "positive regulation of sperm movement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "propanate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "up regulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "up regulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "up-regulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "up-regulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "upregulation of sperm motility" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "upregulation of sperm movement" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902093 ; owl:annotatedTarget "activation of sperm motility" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "propanoate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902105 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of leukocyte differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902105 ; owl:annotatedTarget "regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902105 ; owl:annotatedTarget "regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "propanoic acid, ion(1-)" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down regulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down-regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down-regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "down-regulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "downregulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "downregulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "downregulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17272 ; owl:annotatedTarget "pseudoacetate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "negative regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "negative regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "inhibition of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "inhibition of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902106 ; owl:annotatedTarget "inhibition of leukocyte differentiation" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173084 ; owl:annotatedTarget "PMID:32015325" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:add" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "positive regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "positive regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up regulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up-regulation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up-regulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "up-regulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "upregulation of immune cell differentiation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173084 ; owl:annotatedTarget "PMID:32256352" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "upregulation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "upregulation of leukocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "activation of immune cell differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "activation of leucocyte differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902107 ; owl:annotatedTarget "activation of leukocyte differentiation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173084 ; owl:annotatedTarget "PMID:32413317" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902115 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of organelle assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902116 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902116 ; owl:annotatedTarget "down regulation of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902116 ; owl:annotatedTarget "down-regulation of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902116 ; owl:annotatedTarget "downregulation of organelle assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173084 ; owl:annotatedTarget "PMID:33495651" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902116 ; owl:annotatedTarget "inhibition of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902117 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of organelle assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902117 ; owl:annotatedTarget "up regulation of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902117 ; owl:annotatedTarget "up-regulation of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902117 ; owl:annotatedTarget "upregulation of organelle assembly" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_173084 ; owl:annotatedTarget "ferroptosis inhibitors" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902117 ; owl:annotatedTarget "activation of organelle assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902221 ; owl:annotatedTarget "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902221 ; owl:annotatedTarget "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902224 ; owl:annotatedTarget "The chemical reactions and pathways involving ketone body." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902224 ; owl:annotatedTarget "ketone body metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173085 ; owl:annotatedTarget "PMID:31899616" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16163358" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "Any apoptotic process that is involved in blood vessel morphogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "apoptotic cell death involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "apoptotic programmed cell death involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "programmed cell death by apoptosis involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "apoptosis involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "apoptotic program involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "type I programmed cell death involved in patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902262 ; owl:annotatedTarget "signaling (initiator) caspase activity involved in patterning of blood vessels" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173085 ; owl:annotatedTarget "PMID:32015325" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bf", "GOC:vw", "GO_REF:0000058", "PMID:18314879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902275 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of chromatin organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902275 ; owl:annotatedTarget "regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902275 ; owl:annotatedTarget "regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173085 ; owl:annotatedTarget "PMID:33167414" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:sart", "PMID:12202035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902337 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902337 ; owl:annotatedTarget "regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902337 ; owl:annotatedTarget "regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902337 ; owl:annotatedTarget "regulation of morphogenetic apoptosis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_173085 ; owl:annotatedTarget "PMID:34012798" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:sart", "PMID:12202035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down regulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down-regulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "downregulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down-regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "downregulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "inhibition of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "inhibition of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "negative regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_173085 ; owl:annotatedTarget "ferroptosis inducers" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down-regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "down-regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "downregulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "downregulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "inhibition of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "inhibition of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "negative regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902338 ; owl:annotatedTarget "negative regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:sart", "PMID:12202035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up regulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up-regulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "upregulation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "activation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "activation of apoptotic process involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "positive regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up-regulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "upregulation of apoptosis involved in morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "activation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "activation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "positive regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "positive regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up-regulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "up-regulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "upregulation of apoptosis involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902339 ; owl:annotatedTarget "upregulation of morphogenetic apoptosis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "PMID:23219725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902340 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902340 ; owl:annotatedTarget "down regulation of chromosome condensation" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902340 ; owl:annotatedTarget "inhibition of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902340 ; owl:annotatedTarget "inhibition of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17325 ; owl:annotatedTarget "3-hydroxy-3-methylglutarate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:hjd", "PMID:22539676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902490 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of sperm capacitation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902490 ; owl:annotatedTarget "regulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:hjd", "PMID:22539676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "down regulation of sperm capacitation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "down-regulation of sperm capacitation" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "downregulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "inhibition of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902491 ; owl:annotatedTarget "negative regulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:hjd", "PMID:22539676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of sperm capacitation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "up regulation of sperm capacitation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "up-regulation of sperm capacitation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "upregulation of sperm capacitation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "activation of sperm capacitation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "activation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "positive regulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "up regulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "up-regulation of sperm activation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902492 ; owl:annotatedTarget "upregulation of sperm activation" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902531 ; owl:annotatedTarget "regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902531 ; owl:annotatedTarget "regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902531 ; owl:annotatedTarget "regulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902531 ; owl:annotatedTarget "regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902531 ; owl:annotatedTarget "regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Beilstein:1915399" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of intracellular signaling chain" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Beilstein:3653705" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of intracellular signaling cascade" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "CAS:58-22-0" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "down-regulation of signal transmission via intracellular cascade" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "CAS:58-22-0" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "downregulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "inhibition of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902532 ; owl:annotatedTarget "negative regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "CAS:58-22-0" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of intracellular signal transduction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of intracellular signal transduction" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Drug_Central:2607" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of intracellular signaling chain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of signal transmission via intracellular cascade" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Gmelin:538843" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of intracellular signal transduction pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of signal transmission via intracellular cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "activation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "positive regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02020002" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "up-regulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of intracellular signaling cascade" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of intracellular signaling pathway" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902533 ; owl:annotatedTarget "upregulation of signal transduction via intracellular signaling cascade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "PMID:10438974" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:1826836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902622 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of neutrophil migration." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:1826836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902623 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902623 ; owl:annotatedTarget "down regulation of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902623 ; owl:annotatedTarget "down-regulation of neutrophil migration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "PMID:11786693" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902623 ; owl:annotatedTarget "downregulation of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902623 ; owl:annotatedTarget "inhibition of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:1826836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902624 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of neutrophil migration." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902624 ; owl:annotatedTarget "up regulation of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902624 ; owl:annotatedTarget "up-regulation of neutrophil migration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "PMID:18900503" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902624 ; owl:annotatedTarget "upregulation of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902624 ; owl:annotatedTarget "activation of neutrophil migration" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mengo_curators", "GO_REF:0000068", "PMID:11288200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902652 ; owl:annotatedTarget "The chemical reactions and pathways involving secondary alcohol." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902652 ; owl:annotatedTarget "secondary alcohol metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16159377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902721 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "PMID:24498482" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902721 ; owl:annotatedTarget "down regulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902721 ; owl:annotatedTarget "down-regulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902721 ; owl:annotatedTarget "downregulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902721 ; owl:annotatedTarget "inhibition of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16159377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902722 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of prolactin secretion." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Reaxys:1915399" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902722 ; owl:annotatedTarget "up regulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902722 ; owl:annotatedTarget "up-regulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902722 ; owl:annotatedTarget "upregulation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902722 ; owl:annotatedTarget "activation of prolactin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:pg", "GO_REF:0000060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "Any apoptotic process that is involved in anatomical structure development." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "17beta-hydroxyandrost-4-en-3-one" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "TESTOSTERONE" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis activator activity involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "apoptosis activator activity involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "commitment to apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Testosterone" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "commitment to apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "induction of apoptosis by p53 involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "induction of apoptosis by p53 involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "induction of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "induction of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "signaling (initiator) caspase activity involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902742 ; owl:annotatedTarget "signaling (initiator) caspase activity involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "testosterone" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000060", "PMID:18799626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1902850 ; owl:annotatedTarget "Any microtubule cytoskeleton organization that is involved in mitosis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902850 ; owl:annotatedTarget "microtubule cytoskeleton organisation involved in mitosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1902850 ; owl:annotatedTarget "microtubule dynamics involved in mitosis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1902850 ; owl:annotatedTarget "microtubule cytoskeleton organization and biogenesis involved in mitosis" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "17beta-Hydroxy-4-androsten-3-one" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903010 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bone development." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903011 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903011 ; owl:annotatedTarget "down regulation of bone development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903011 ; owl:annotatedTarget "down-regulation of bone development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903011 ; owl:annotatedTarget "downregulation of bone development" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "17beta-hydroxy-4-androsten-3-one" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903011 ; owl:annotatedTarget "inhibition of bone development" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903012 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bone development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903012 ; owl:annotatedTarget "up regulation of bone development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903012 ; owl:annotatedTarget "up-regulation of bone development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903012 ; owl:annotatedTarget "upregulation of bone development" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "4-androsten-17beta-ol-3-one" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903012 ; owl:annotatedTarget "activation of bone development" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903018 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903018 ; owl:annotatedTarget "regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Androderm" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "down regulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "down regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "down-regulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "down-regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "downregulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "downregulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "Testosteron" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "negative regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "inhibition of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903019 ; owl:annotatedTarget "inhibition of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "positive regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "testosterona" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "up regulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "up regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "up-regulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "up-regulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "upregulation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "upregulation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "activation of glycoprotein metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903020 ; owl:annotatedTarget "activation of glycoprotein metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "testosterone" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv", "GO_REF:0000058", "PMID:19164535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903034 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of response to wounding." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903034 ; owl:annotatedTarget "regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17347 ; owl:annotatedTarget "testosteronum" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv", "GO_REF:0000058", "PMID:19164535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "down regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "down regulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "down-regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "down-regulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "downregulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "downregulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "negative regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "inhibition of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903035 ; owl:annotatedTarget "inhibition of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv", "GO_REF:0000058", "PMID:19164535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of response to wounding." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "positive regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "up regulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "up regulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "up-regulation of physiological response to wounding" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "CAS:14265-45-3" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "up-regulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "upregulation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "upregulation of response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "activation of physiological response to wounding" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903036 ; owl:annotatedTarget "activation of response to wounding" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "Gmelin:1449" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903037 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903037 ; owl:annotatedTarget "regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903037 ; owl:annotatedTarget "regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "sulfite" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down regulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down-regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down-regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "down-regulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "downregulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "downregulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "downregulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "negative regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "negative regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "sulfite" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "inhibition of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "inhibition of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903038 ; owl:annotatedTarget "inhibition of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "positive regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "trioxidosulfate(2-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "positive regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up regulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up-regulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up-regulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "up-regulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "upregulation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "upregulation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "upregulation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "trioxosulfate(2-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "activation of leukocyte adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "activation of leukocyte cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903039 ; owl:annotatedTarget "activation of leukocyte cell-cell adhesion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903046 ; owl:annotatedTarget "A process that is part of the meiotic cell cycle." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "trioxosulfate(IV)" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903047 ; owl:annotatedTarget "A process that is part of the mitotic cell cycle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "SO3" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903053 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of extracellular matrix organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903053 ; owl:annotatedTarget "regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903053 ; owl:annotatedTarget "regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "SO3(2-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down regulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down-regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down-regulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "downregulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "downregulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "negative regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "inhibition of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "inhibition of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "down-regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "SULFITE ION" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "downregulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "inhibition of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903054 ; owl:annotatedTarget "negative regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "positive regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "[SO3](2-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up regulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up-regulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up-regulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "upregulation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "upregulation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "activation of extracellular matrix organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "activation of extracellular matrix organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "activation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "positive regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17359 ; owl:annotatedTarget "sulphite" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "up-regulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903055 ; owl:annotatedTarget "upregulation of extracellular matrix organization and biogenesis" . [] oboInOwl:hasDbXref "CL:0000842", "GOC:TermGenie", "GO_REF:0000086", "PMID:24759906" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903131 ; owl:annotatedTarget "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16782817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903294 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16782817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903295 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903295 ; owl:annotatedTarget "down regulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903295 ; owl:annotatedTarget "down-regulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903295 ; owl:annotatedTarget "downregulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903295 ; owl:annotatedTarget "inhibition of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16782817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903296 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903296 ; owl:annotatedTarget "up regulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903296 ; owl:annotatedTarget "up-regulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903296 ; owl:annotatedTarget "upregulation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903296 ; owl:annotatedTarget "activation of glutamate secretion, neurotransmission" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903317 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein maturation." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "Beilstein:1723529" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903318 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903318 ; owl:annotatedTarget "down regulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903318 ; owl:annotatedTarget "down-regulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903318 ; owl:annotatedTarget "downregulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903318 ; owl:annotatedTarget "inhibition of protein maturation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "CAS:1783-96-6" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903319 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of protein maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903319 ; owl:annotatedTarget "up regulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903319 ; owl:annotatedTarget "up-regulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903319 ; owl:annotatedTarget "upregulation of protein maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903319 ; owl:annotatedTarget "activation of protein maturation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "CAS:1783-96-6" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:16943282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of nucleus organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "regulation of nuclear organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "regulation of nuclear organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "regulation of nuclear morphology" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "regulation of nuclear organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903353 ; owl:annotatedTarget "regulation of nucleus organization and biogenesis" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "CAS:1783-96-6" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903379 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903380 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903380 ; owl:annotatedTarget "up regulation of mitotic chromosome condensation" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "Gmelin:602084" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903380 ; owl:annotatedTarget "up-regulation of mitotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903380 ; owl:annotatedTarget "upregulation of mitotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903380 ; owl:annotatedTarget "activation of mitotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903429 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903429 ; owl:annotatedTarget "regulation of functional differentiation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "PMID:11419736" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "down regulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "down-regulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "downregulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "inhibition of cell maturation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "PMID:17118457" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "down regulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "down-regulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "downregulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "inhibition of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903430 ; owl:annotatedTarget "negative regulation of functional differentiation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "PMID:17407322" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell maturation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "up regulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "up-regulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "upregulation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "activation of cell maturation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "activation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "positive regulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "up regulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "up-regulation of functional differentiation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903431 ; owl:annotatedTarget "upregulation of functional differentiation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "PMID:18318836" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:19563620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903487 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lactation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "PMID:19860889" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:19563620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903488 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903488 ; owl:annotatedTarget "down regulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903488 ; owl:annotatedTarget "down-regulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903488 ; owl:annotatedTarget "downregulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903488 ; owl:annotatedTarget "inhibition of lactation" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "Reaxys:1723529" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:19563620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903489 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lactation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903489 ; owl:annotatedTarget "up regulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903489 ; owl:annotatedTarget "up-regulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903489 ; owl:annotatedTarget "upregulation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903489 ; owl:annotatedTarget "activation of lactation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:dph", "GO_REF:0000068", "PMID:9452964" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903509 ; owl:annotatedTarget "The chemical reactions and pathways involving liposaccharide." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903509 ; owl:annotatedTarget "liposaccharide metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:dph", "GO_REF:0000068", "PMID:4236091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903510 ; owl:annotatedTarget "The chemical reactions and pathways involving mucopolysaccharide." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903510 ; owl:annotatedTarget "mucopolysaccharide metabolism" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "(2R)-2-aminobutanedioic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903522 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood circulation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903522 ; owl:annotatedTarget "regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "D-Aspartic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "down regulation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "down-regulation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "downregulation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "inhibition of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "down regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "down-regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "downregulation of hemolymph circulation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "D-aspartic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "inhibition of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903523 ; owl:annotatedTarget "negative regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood circulation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "up regulation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "up-regulation of blood circulation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "(R)-2-aminobutanedioic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "upregulation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "activation of blood circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "activation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "positive regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "up regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "up-regulation of hemolymph circulation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903524 ; owl:annotatedTarget "upregulation of hemolymph circulation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "(R)-2-aminosuccinic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903530 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of secretion by cell." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903530 ; owl:annotatedTarget "regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "PMID:21614077" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "D-Asparaginsaeure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "down regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "down regulation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "down-regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "down-regulation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "downregulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "downregulation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "negative regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "inhibition of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903531 ; owl:annotatedTarget "inhibition of secretion by cell" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "DAS" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of secretion by cell." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "positive regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "up regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "up regulation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "up-regulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "up-regulation of secretion by cell" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17364 ; owl:annotatedTarget "aspartic acid D-form" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "upregulation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "upregulation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "activation of cellular secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903532 ; owl:annotatedTarget "activation of secretion by cell" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903551 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903551 ; owl:annotatedTarget "regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "down regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "down-regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "downregulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "negative regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903552 ; owl:annotatedTarget "inhibition of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "up regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "up-regulation of extracellular vesicular exosome assembly" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "Beilstein:5811" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "upregulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "activation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903553 ; owl:annotatedTarget "positive regulation of extracellular vesicular exosome assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pm", "GO_REF:0000064", "PMID:24769233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903561 ; owl:annotatedTarget "Any vesicle that is part of the extracellular region." . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903561 ; owl:annotatedTarget "microparticle" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "CAS:68-94-0" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903564 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein localization to cilium." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "CAS:68-94-0" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903565 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903565 ; owl:annotatedTarget "down regulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903565 ; owl:annotatedTarget "down-regulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903565 ; owl:annotatedTarget "downregulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903565 ; owl:annotatedTarget "inhibition of protein localization to cilium" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "CAS:68-94-0" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903566 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903566 ; owl:annotatedTarget "up regulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903566 ; owl:annotatedTarget "up-regulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903566 ; owl:annotatedTarget "upregulation of protein localization to cilium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903566 ; owl:annotatedTarget "activation of protein localization to cilium" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "Gmelin:464558" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903706 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of hemopoiesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903706 ; owl:annotatedTarget "regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903706 ; owl:annotatedTarget "regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903706 ; owl:annotatedTarget "regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903706 ; owl:annotatedTarget "regulation of hematopoiesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "electron" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:14253484" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down regulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down regulation of hemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down-regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down-regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down-regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down-regulation of hematopoiesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:1557408" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "down-regulation of hemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "downregulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "downregulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "downregulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "downregulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "downregulation of hemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "negative regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "negative regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "negative regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "negative regulation of hematopoiesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "inhibition of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "inhibition of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "inhibition of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "inhibition of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903707 ; owl:annotatedTarget "inhibition of hemopoiesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:23400363" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of hemopoiesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "positive regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "positive regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "positive regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "positive regulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up regulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up regulation of hemopoiesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:23670363" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up-regulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up-regulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up-regulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up-regulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "up-regulation of hemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "upregulation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "upregulation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "upregulation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "upregulation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "upregulation of hemopoiesis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "PMID:8016081" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "activation of blood cell biosynthesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "activation of blood cell formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "activation of haemopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "activation of hematopoiesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903708 ; owl:annotatedTarget "activation of hemopoiesis" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "Reaxys:5811" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24514900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903729 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of plasma membrane organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903729 ; owl:annotatedTarget "regulation of plasma membrane organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903729 ; owl:annotatedTarget "regulation of plasma membrane organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000059", "PMID:11927518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of beta-D-galactanase activity" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "1,7-dihydro-6H-purin-6-one" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of beta-D-galactoside galactohydrolase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of beta-D-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of beta-galactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of beta-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of exo-(1->4)-beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down regulation of trilactase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of beta-D-galactoside galactohydrolase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of beta-D-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of beta-galactosidase activity" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "HYPOXANTHINE" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of beta-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of exo-(1->4)-beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "down-regulation of trilactase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of beta-D-galactoside galactohydrolase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of beta-D-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of beta-galactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of beta-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of exo-(1->4)-beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "downregulation of trilactase activity" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17368 ; owl:annotatedTarget "Hypoxanthine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of beta-D-galactoside galactohydrolase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of beta-D-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of beta-lactosidase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of exo-(1->4)-beta-D-galactanase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "negative regulation of trilactase activity" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903770 ; owl:annotatedTarget "inhibition of beta-D-galactanase activity" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up regulation of oryzatym" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up regulation of sumiklat" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of S 2107" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "electron" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17375 ; owl:annotatedTarget "(S)-2-Hydroxy acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of hydrolact" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of lactose hydrolysis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of lactozym" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of maxilact" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of oryzatym" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "up-regulation of sumiklat" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "upregulation of S 2107" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "upregulation of hydrolact" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "upregulation of lactose hydrolysis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1903771 ; owl:annotatedTarget "upregulation of lactozym" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "down-regulation of cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "down-regulation of cellular protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "downregulation of cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "downregulation of cellular protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "negative regulation of cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "inhibition of cellular protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903828 ; owl:annotatedTarget "inhibition of cellular protein localization" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17375 ; owl:annotatedTarget "(S)-2-Hydroxymonocarboxylic acid" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903941 ; owl:annotatedTarget "downregulation of respiratory gaseous exchange" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1903941 ; owl:annotatedTarget "inhibition of respiratory gaseous exchange" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:22819705" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903942 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903942 ; owl:annotatedTarget "up regulation of respiratory gaseous exchange" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903998 ; owl:annotatedTarget "regulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11961051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "down regulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "down regulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "down-regulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "down-regulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "downregulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1903999 ; owl:annotatedTarget "downregulation of eating behaviour" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Beilstein:1728091" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "positive regulation of eating behaviour" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "CAS:923-32-0" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "up regulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "up regulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "up-regulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "up-regulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "upregulation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "upregulation of eating behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "activation of eating behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904000 ; owl:annotatedTarget "activation of eating behaviour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "Elektron" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "CAS:923-32-0" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:21472453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of vasculature development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "up regulation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "up-regulation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "upregulation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "activation of vasculature development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "activation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "positive regulation of vascular system development" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Gmelin:83347" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "up regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "up-regulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904018 ; owl:annotatedTarget "upregulation of vascular system development" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down regulation of nociception" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "PMID:18608550" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down regulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down-regulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down-regulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "downregulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "downregulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "negative regulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down regulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "down-regulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "downregulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "inhibition of nociception" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "PMID:24327171" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "inhibition of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "inhibition of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904057 ; owl:annotatedTarget "negative regulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "positive regulation of nociception" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "PMID:24525029" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up regulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up regulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up-regulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up-regulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "upregulation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "upregulation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "activation of nociception" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "activation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "activation of sensory perception of pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "positive regulation of perception of physiological pain" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "PMID:24525030" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up regulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "up-regulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904058 ; owl:annotatedTarget "upregulation of perception of physiological pain" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:kmv", "GO_REF:0000060", "PMID:22665789" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "Any G protein-coupled receptor signaling pathway that is involved in social behavior." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signaling pathway involved in social behavior" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Reaxys:1728091" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signaling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signalling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signalling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signal transduction involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signal transduction involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signaling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signaling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor signaling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor signalling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor signalling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "3,3'-disulfanediylbis(2-aminopropanoic acid)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signaling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signaling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signalling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signalling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signaling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signaling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signalling pathway involved in social behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signalling pathway involved in social behaviour" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signaling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G protein coupled receptor protein signalling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Cystine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signal transduction involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor signaling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein coupled receptor signalling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signaling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904068 ; owl:annotatedTarget "GPCR signalling pathway involved in cooperative behavior" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "cystine" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24509081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904098 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904098 ; owl:annotatedTarget "regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "beta" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "3,3'-dithiobis(2-aminopropanoic acid)" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24509081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "down regulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "down regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "down-regulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "down-regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "downregulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "downregulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "negative regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "inhibition of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904099 ; owl:annotatedTarget "inhibition of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Cystin" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:24509081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "positive regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "up regulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "up regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "up-regulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Dicysteine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "up-regulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "upregulation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "upregulation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "activation of protein O-linked glycosylation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904100 ; owl:annotatedTarget "activation of protein amino acid O-linked glycosylation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "Zystin" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000064", "PMID:18667152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904115 ; owl:annotatedTarget "Any cytoplasm that is part of a axon." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904170 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bleb assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904170 ; owl:annotatedTarget "regulation of cell blebbing" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "alpha-Diamino-beta-dithiolactic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "down regulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "down regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "down-regulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "down-regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "downregulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "downregulation of cell blebbing" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17376 ; owl:annotatedTarget "cistina" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "negative regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "inhibition of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904171 ; owl:annotatedTarget "inhibition of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bleb assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "positive regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "up regulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "up regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "up-regulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "up-regulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "upregulation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "upregulation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "activation of bleb assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904172 ; owl:annotatedTarget "activation of cell blebbing" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904251 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of bile acid metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904251 ; owl:annotatedTarget "regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "down regulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "down regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "down-regulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "down-regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "downregulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "downregulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "negative regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "inhibition of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904252 ; owl:annotatedTarget "inhibition of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "positive regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "up regulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "up regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "up-regulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "beta(-)" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "Beilstein:220051" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "up-regulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "upregulation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "upregulation of bile acid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "activation of bile acid metabolic process" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904253 ; owl:annotatedTarget "activation of bile acid metabolism" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "CAS:487-90-1" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904304 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904305 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904305 ; owl:annotatedTarget "down regulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904305 ; owl:annotatedTarget "down-regulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904305 ; owl:annotatedTarget "downregulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "CAS:487-90-1" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904305 ; owl:annotatedTarget "inhibition of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904306 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904306 ; owl:annotatedTarget "up regulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904306 ; owl:annotatedTarget "up-regulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904306 ; owl:annotatedTarget "upregulation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:21383008" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904306 ; owl:annotatedTarget "activation of gastro-intestinal system smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:18562635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904318 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904318 ; owl:annotatedTarget "regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904318 ; owl:annotatedTarget "regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:21627493" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:18562635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down regulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down-regulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "downregulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "inhibition of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down regulation of smooth muscle contraction involved in urination" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:22279024" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down-regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "down-regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "downregulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "downregulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "inhibition of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "inhibition of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "negative regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904319 ; owl:annotatedTarget "negative regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:22740490" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:18562635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up regulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up-regulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "upregulation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "activation of smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "activation of smooth muscle contraction involved in urination" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "activation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "positive regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "positive regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up-regulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "up-regulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "upregulation of smooth muscle contraction involved in urination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904320 ; owl:annotatedTarget "upregulation of urinary bladder smooth muscle contraction involved in micturition" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "PMID:22974111" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904347 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "Reaxys:220051" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904348 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904348 ; owl:annotatedTarget "down regulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904348 ; owl:annotatedTarget "down-regulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904348 ; owl:annotatedTarget "downregulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904348 ; owl:annotatedTarget "inhibition of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "beta-particle" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904349 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904349 ; owl:annotatedTarget "up regulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904349 ; owl:annotatedTarget "up-regulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904349 ; owl:annotatedTarget "upregulation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904349 ; owl:annotatedTarget "activation of small intestine smooth muscle contraction" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17381 ; owl:annotatedTarget "Porphobilinogen" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11278900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904362 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of calcitonin secretion." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11278900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904363 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904363 ; owl:annotatedTarget "down regulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904363 ; owl:annotatedTarget "down-regulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904363 ; owl:annotatedTarget "downregulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904363 ; owl:annotatedTarget "inhibition of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:11278900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904364 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904364 ; owl:annotatedTarget "up regulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904364 ; owl:annotatedTarget "up-regulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904364 ; owl:annotatedTarget "upregulation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904364 ; owl:annotatedTarget "activation of calcitonin secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904409 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of secretory granule organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904409 ; owl:annotatedTarget "regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904409 ; owl:annotatedTarget "regulation of secretory granule organization and biogenesis" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Beilstein:969454" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down regulation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down-regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down-regulation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "downregulation of secretory granule organisation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "CAS:109-52-4" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "downregulation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "negative regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "inhibition of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "inhibition of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down regulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "down-regulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "downregulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "inhibition of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904410 ; owl:annotatedTarget "negative regulation of secretory granule organization and biogenesis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "CAS:109-52-4" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of secretory granule organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "positive regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up regulation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up-regulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up-regulation of secretory granule organization" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "CAS:109-52-4" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "upregulation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "upregulation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "activation of secretory granule organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "activation of secretory granule organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "activation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "positive regulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up regulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "up-regulation of secretory granule organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904411 ; owl:annotatedTarget "upregulation of secretory granule organization and biogenesis" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Gmelin:26714" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:12469120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904478 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of intestinal absorption." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010005" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:12469120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904479 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904479 ; owl:annotatedTarget "down regulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904479 ; owl:annotatedTarget "down-regulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904479 ; owl:annotatedTarget "downregulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904479 ; owl:annotatedTarget "inhibition of intestinal absorption" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "e" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "PMID:20507156" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:12469120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904480 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of intestinal absorption." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904480 ; owl:annotatedTarget "up regulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904480 ; owl:annotatedTarget "up-regulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904480 ; owl:annotatedTarget "upregulation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904480 ; owl:annotatedTarget "activation of intestinal absorption" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000069", "PMID:9090050" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904659 ; owl:annotatedTarget "The process in which glucose is transported across a membrane." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Reaxys:969454" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904675 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of somatic stem cell division." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904675 ; owl:annotatedTarget "regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "down regulation of somatic stem cell division" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Valeric acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "down regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "down-regulation of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "down-regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "downregulation of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "downregulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "negative regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "inhibition of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904676 ; owl:annotatedTarget "inhibition of somatic stem cell renewal" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "pentanoic acid" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "positive regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "up regulation of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "up regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "up-regulation of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "up-regulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "upregulation of somatic stem cell division" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "1-butanecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "upregulation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "activation of somatic stem cell division" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904677 ; owl:annotatedTarget "activation of somatic stem cell renewal" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "1-butanecarboxylic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "CH3-[CH2]3-COOH" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "PENTANOIC ACID" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Pentanoate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Pentanoic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down regulation of type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "e(-)" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "Valerate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "down-regulation of apoptotic program involved in development of an anatomical structure" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of commitment to apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of induction of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "propylacetic acid" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of induction of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904746 ; owl:annotatedTarget "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_10545 ; owl:annotatedTarget "e-" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17418 ; owl:annotatedTarget "valeric acid, normal" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17453 ; owl:annotatedTarget "Beilstein:3904597" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic process involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic process involved in development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic process involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of apoptotic programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of programmed cell death by apoptosis involved in anatomical structure development" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17453 ; owl:annotatedTarget "Gmelin:142212" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of programmed cell death by apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "activation of type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17453 ; owl:annotatedTarget "Reaxys:3904597" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "positive regulation of type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17453 ; owl:annotatedTarget "methylpropanedioate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up regulation of type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of activation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of activation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17453 ; owl:annotatedTarget "methylmalonate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904747 ; owl:annotatedTarget "up-regulation of apoptotic program involved in development of an anatomical structure" . 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[] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptosis signaling involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptosis signaling involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptotic program involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptotic program involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of type I programmed cell death involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of type I programmed cell death involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptosis activator activity involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of apoptosis activator activity involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of commitment to apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "RCHO" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of commitment to apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of induction of apoptosis by p53 involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of induction of apoptosis involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of induction of apoptosis involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of signaling (initiator) caspase activity involved in anatomical structure development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1904748 ; owl:annotatedTarget "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000088", "PMID:9606181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904949 ; owl:annotatedTarget "A protein complex which is capable of ATPase activity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "aldehido" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down regulation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down regulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down-regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down-regulation of establishment of protein localization" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "aldehidos" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down-regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "down-regulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "downregulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "downregulation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "downregulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "downregulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "negative regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "negative regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "negative regulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "inhibition of establishment of protein localisation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "aldehydes" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "inhibition of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "inhibition of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904950 ; owl:annotatedTarget "inhibition of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "positive regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "aldehydum" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "positive regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "positive regulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up regulation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up regulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up-regulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up-regulation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up-regulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "up-regulation of protein recruitment" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17478 ; owl:annotatedTarget "an aldehyde" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "upregulation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "upregulation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "upregulation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "upregulation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "activation of establishment of protein localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "activation of establishment of protein localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "activation of protein positioning" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1904951 ; owl:annotatedTarget "activation of protein recruitment" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:25954280" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905038 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905038 ; owl:annotatedTarget "regulation of membrane lipid metabolism" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:25738458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905082 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905082 ; owl:annotatedTarget "regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:25738458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "down regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "down regulation of mitochondrial translational elongation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "CAS:462-10-2" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "down-regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "down-regulation of mitochondrial translational elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "downregulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "downregulation of mitochondrial translational elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "negative regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "inhibition of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905083 ; owl:annotatedTarget "inhibition of mitochondrial translational elongation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "CAS:462-10-2" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:25738458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "positive regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "up regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "up regulation of mitochondrial translational elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "up-regulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "up-regulation of mitochondrial translational elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "upregulation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "upregulation of mitochondrial translational elongation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "PMID:11592966" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "activation of mitochondrial translation elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905084 ; owl:annotatedTarget "activation of mitochondrial translational elongation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000060", "ISBN:0-7167-3051-0" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signal transduction involved in cell-cell signaling" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signal transduction involved in cell-cell signalling" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "PMID:11896744" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signaling pathway involved in cell-cell signaling" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signaling pathway involved in cell-cell signalling" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signalling pathway involved in cell-cell signaling" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor linked signalling pathway involved in cell-cell signalling" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905114 ; owl:annotatedTarget "cell surface receptor signaling pathway involved in cell-cell signalling" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "Reaxys:1728581" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905153 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of membrane invagination." . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905154 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905154 ; owl:annotatedTarget "down regulation of membrane invagination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905154 ; owl:annotatedTarget "down-regulation of membrane invagination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905154 ; owl:annotatedTarget "downregulation of membrane invagination" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "4,4'-disulfanediylbis(2-aminobutanoic acid)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905154 ; owl:annotatedTarget "inhibition of membrane invagination" . [] oboInOwl:hasDbXref "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905155 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of membrane invagination." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905155 ; owl:annotatedTarget "up regulation of membrane invagination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905155 ; owl:annotatedTarget "up-regulation of membrane invagination" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905155 ; owl:annotatedTarget "upregulation of membrane invagination" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "Homocystine" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905155 ; owl:annotatedTarget "activation of membrane invagination" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:23219725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905213 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "4,4'-Dithiobis(2-aminobutyric acid)" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down regulation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down-regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down-regulation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "down-regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "downregulation of chromatin organisation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17485 ; owl:annotatedTarget "4,4'-dithiobis(2-aminobutyric acid)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "downregulation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "downregulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "negative regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "negative regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "inhibition of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "inhibition of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905268 ; owl:annotatedTarget "inhibition of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17522 ; owl:annotatedTarget "Alditol" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of chromatin organization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "positive regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "positive regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up regulation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up-regulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up-regulation of chromatin organization" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17522 ; owl:annotatedTarget "alditol" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "up-regulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "upregulation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "upregulation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "upregulation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "activation of chromatin organisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "activation of chromatin organization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905269 ; owl:annotatedTarget "activation of establishment or maintenance of chromatin architecture" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17522 ; owl:annotatedTarget "Glycitol" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905276 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of epithelial tube formation." . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905277 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905277 ; owl:annotatedTarget "down regulation of epithelial tube formation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17522 ; owl:annotatedTarget "Sugar alcohol" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905277 ; owl:annotatedTarget "down-regulation of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905277 ; owl:annotatedTarget "downregulation of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905277 ; owl:annotatedTarget "inhibition of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905278 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905278 ; owl:annotatedTarget "up regulation of epithelial tube formation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17522 ; owl:annotatedTarget "alditols" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905278 ; owl:annotatedTarget "up-regulation of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905278 ; owl:annotatedTarget "upregulation of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905278 ; owl:annotatedTarget "activation of epithelial tube formation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905330 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905330 ; owl:annotatedTarget "regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "down regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "down regulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "down-regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "down-regulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:RO_0002022 ; owl:annotatedTarget "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_11596 ; owl:annotatedTarget "Beilstein:5736650" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "downregulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "downregulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "negative regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "inhibition of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905331 ; owl:annotatedTarget "inhibition of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "positive regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "up regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "up regulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "up-regulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "up-regulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "upregulation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "upregulation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "activation of epithelium morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905332 ; owl:annotatedTarget "activation of morphogenesis of an epithelium" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GO_REF:0000079", "PMID:21725307", "PMID:23644468", "PMID:24448408", "PMID:26595381", "PMID:26982032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "cilial transition zone assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "cilial transition zone formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "ciliary transition zone formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "cilium transition zone assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905349 ; owl:annotatedTarget "cilium transition zone formation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:al", "GOC:vw", "GO_REF:0000060", "PMID:15917811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "Any intracellular signal transduction that is involved in positive regulation of cell growth." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular protein kinase cascade involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signal transduction pathway involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling chain involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in up regulation of cell growth" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "Beilstein:3903504" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "protein kinase cascade involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transmission via intracellular cascade involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in positive regulation of cell growth" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "CAS:71-52-3" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling cascade involved in upregulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "intracellular signaling pathway involved in upregulation of cell growth" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "Gmelin:49249" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in activation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905427 ; owl:annotatedTarget "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:17215880" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of motile cilium assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905503 ; owl:annotatedTarget "regulation of nodal cilium formation" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_11596 ; owl:annotatedTarget "Reaxys:5736650" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:17505962" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of motile primary cilium assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:18439416" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "down-regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of motile primary cilia assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:28732801" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "downregulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "inhibition of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "negative regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "negative regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "negative regulation of motile primary cilium formation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:29150416" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "negative regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905504 ; owl:annotatedTarget "negative regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of motile primary cilia formation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:29460248" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "activation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "positive regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "positive regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "positive regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "positive regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "positive regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of motile primary cilia assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:29466234" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of nodal cilium assembly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "PMID:4208463" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "up-regulation of nodal cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of motile primary cilia assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of motile primary cilia formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of motile primary cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of motile primary cilium formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of nodal cilium assembly" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_1905505 ; owl:annotatedTarget "upregulation of nodal cilium formation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "Hydrogencarbonate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:hbye", "GO_REF:0000058", "PMID:27564576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of fertilization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "positive regulation of syngamy" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "up regulation of fertilization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "up regulation of syngamy" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "up-regulation of fertilization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "up-regulation of syngamy" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "upregulation of fertilization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "upregulation of syngamy" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogen(trioxidocarbonate)(1-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "activation of fertilization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905516 ; owl:annotatedTarget "activation of syngamy" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905553 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood vessel branching." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905553 ; owl:annotatedTarget "regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogencarbonate" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "down regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "down regulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "down-regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "down-regulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "downregulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_11596 ; owl:annotatedTarget "2-hydroxypentanedioate" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogencarbonate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "downregulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "negative regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "inhibition of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905554 ; owl:annotatedTarget "inhibition of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood vessel branching." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogencarbonate(1-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "positive regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "up regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "up regulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "up-regulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "up-regulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "upregulation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "upregulation of patterning of blood vessels" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "activation of branching involved in blood vessel morphogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905555 ; owl:annotatedTarget "activation of patterning of blood vessels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogentrioxocarbonate(1-)" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:23419067" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "down regulation of saliva secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "down regulation of salivation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "down-regulation of saliva secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "down-regulation of salivation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "downregulation of saliva secretion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogentrioxocarbonate(IV)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "downregulation of salivation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "negative regulation of salivation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "inhibition of saliva secretion" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905747 ; owl:annotatedTarget "inhibition of salivation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:8692859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydroxidodioxidocarbonate(1-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905787 ; owl:annotatedTarget "regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "Acid carbonate" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:8692859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "BICARBONATE ION" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "down-regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "Bicarbonate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "downregulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "negative regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "HCO3(-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905788 ; owl:annotatedTarget "inhibition of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "HCO3-" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:8692859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "positive regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_11596 ; owl:annotatedTarget "2-hydroxyglutarate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "[CO2(OH)](-)" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17544 ; owl:annotatedTarget "hydrogen carbonate" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "up-regulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "upregulation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of detection of mechanical stimulus involved in sensory perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of perception of touch, detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of perception of touch, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of perception of touch, sensory transduction of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of sensory detection of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of sensory transduction of mechanical stimulus during perception of touch" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905789 ; owl:annotatedTarget "activation of tactition, sensory detection of mechanical stimulus" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:17268547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of chromosome condensation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "positive regulation of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "positive regulation of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up regulation of chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up regulation of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up regulation of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up-regulation of chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up-regulation of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "up-regulation of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "upregulation of chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "upregulation of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "upregulation of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "activation of chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "activation of eukaryotic chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905821 ; owl:annotatedTarget "activation of nuclear chromosome condensation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905879 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of oogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905879 ; owl:annotatedTarget "regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "down regulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "down regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "down-regulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "down-regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "downregulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "downregulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "negative regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "inhibition of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905880 ; owl:annotatedTarget "inhibition of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of oogenesis." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "positive regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "up regulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "up regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "up-regulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "up-regulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "upregulation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "upregulation of ovum development" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "activation of oogenesis" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905881 ; owl:annotatedTarget "activation of ovum development" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905902 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mesoderm formation." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905903 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905903 ; owl:annotatedTarget "down regulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905903 ; owl:annotatedTarget "down-regulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905903 ; owl:annotatedTarget "downregulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905903 ; owl:annotatedTarget "inhibition of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905904 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mesoderm formation." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905904 ; owl:annotatedTarget "up regulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905904 ; owl:annotatedTarget "up-regulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905904 ; owl:annotatedTarget "upregulation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905904 ; owl:annotatedTarget "activation of mesoderm formation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000062", "PMID:8087883" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905951 ; owl:annotatedTarget "Any DNA recombination that takes place in mitochondrion." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905951 ; owl:annotatedTarget "DNA recombination in mitochondria" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905952 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of lipid localization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905952 ; owl:annotatedTarget "regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "down regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "down regulation of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "down-regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "down-regulation of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "downregulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "downregulation of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "negative regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "inhibition of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905953 ; owl:annotatedTarget "inhibition of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of lipid localization." . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "positive regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "up regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "up regulation of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "up-regulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "up-regulation of lipid localization" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "upregulation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "upregulation of lipid localization" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "Beilstein:1759139" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "activation of lipid localisation" . [] oboInOwl:hasDbXref "GOC:TermGenie" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:GO_1905954 ; owl:annotatedTarget "activation of lipid localization" . [] oboInOwl:hasDbXref "GOC:bhm", "PMID:16540464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1990234 ; owl:annotatedTarget "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." . [] oboInOwl:hasDbXref "PMID:1826836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1990266 ; owl:annotatedTarget "The movement of a neutrophil within or between different tissues and organs of the body." . [] oboInOwl:hasDbXref "PMID:11991626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1990770 ; owl:annotatedTarget "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." . [] oboInOwl:hasDbXref "GOC:vesicles" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_1990777 ; owl:annotatedTarget "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "CAS:106-60-5" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000026 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of multicellular organismal development." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000027 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000027 ; owl:annotatedTarget "regulation of histogenesis and organogenesis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "CAS:106-60-5" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000035 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of stem cell division." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000035 ; owl:annotatedTarget "regulation of stem cell renewal" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "Drug_Central:166" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000106 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000107 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:11303952" . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:mtg_apoptosis" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000108 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:15756058" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000145 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of cell motility." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000145 ; owl:annotatedTarget "regulation of cell locomotion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000145 ; owl:annotatedTarget "regulation of movement of a cell" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000145 ; owl:annotatedTarget "regulation of cell movement" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000146 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:15996585" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000146 ; owl:annotatedTarget "negative regulation of cell locomotion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000146 ; owl:annotatedTarget "negative regulation of movement of a cell" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000146 ; owl:annotatedTarget "negative regulation of cell movement" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000147 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cell motility." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000147 ; owl:annotatedTarget "positive regulation of cell locomotion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:18982627" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000147 ; owl:annotatedTarget "positive regulation of movement of a cell" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000147 ; owl:annotatedTarget "positive regulation of cell movement" . [] oboInOwl:hasDbXref "GOC:cilia", "GOC:jl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000155 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:19378778" . [] oboInOwl:hasDbXref "GOC:dph", "GOC:yaf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000181 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000214 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of proline metabolic process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:22378066" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000214 ; owl:annotatedTarget "regulation of proline metabolism" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000215 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000215 ; owl:annotatedTarget "negative regulation of proline metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:22700502" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000216 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of proline metabolic process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000216 ; owl:annotatedTarget "positive regulation of proline metabolism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23242333" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000241 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of reproductive process." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000242 ; owl:annotatedTarget "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23291627" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000243 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of reproductive process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "negative regulation of behavioral response to food" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23299429" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "negative regulation of behavioural response to food" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "negative regulation of feeding behaviour" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "negative regulation of drinking" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000252 ; owl:annotatedTarget "negative regulation of eating" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of feeding behavior." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23307195" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "positive regulation of behavioral response to food" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "positive regulation of behavioural response to food" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "positive regulation of feeding behaviour" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "positive regulation of drinking" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000253 ; owl:annotatedTarget "positive regulation of eating" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23339045" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000257 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of protein activation cascade." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000257 ; owl:annotatedTarget "regulation of protein activation pathway" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000257 ; owl:annotatedTarget "regulation of protein activitory cascade" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000258 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000258 ; owl:annotatedTarget "negative regulation of protein activation pathway" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:23360321" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000258 ; owl:annotatedTarget "negative regulation of protein activitory cascade" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000259 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of protein activation cascade." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000259 ; owl:annotatedTarget "positive regulation of protein activation pathway" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000259 ; owl:annotatedTarget "positive regulation of protein activitory cascade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "PMID:7890117" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000260 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "Reaxys:1759139" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000261 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000262 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "5-amino-4-oxopentanoic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000263 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000264 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "5-ALA" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000265 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "5-Amino-4-oxopentanoate" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000266 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000267 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "5-Amino-4-oxovaleric acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000268 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000272 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "5-Aminolevulinate" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000273 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "aminolevulinic acid" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000292 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of defecation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000293 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_11955 ; owl:annotatedTarget "CAS:352-21-6" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "dALA" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000294 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of defecation." . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000377 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000377 ; owl:annotatedTarget "regulation of ROS metabolic process" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "delta-ALA" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000377 ; owl:annotatedTarget "regulation of reactive oxygen species metabolism" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000378 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000378 ; owl:annotatedTarget "negative regulation of ROS metabolic process" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000378 ; owl:annotatedTarget "negative regulation of reactive oxygen species metabolism" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17549 ; owl:annotatedTarget "delta-aminolevulinic acid" . [] oboInOwl:hasDbXref "GOC:mah" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000379 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000379 ; owl:annotatedTarget "positive regulation of ROS metabolic process" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000379 ; owl:annotatedTarget "positive regulation of reactive oxygen species metabolism" . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000380 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mesoderm development." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000381 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000382 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mesoderm development." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000383 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of ectoderm development." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000384 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." . [] oboInOwl:hasDbXref "GOC:BHF" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000385 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of ectoderm development." . [] oboInOwl:hasDbXref "GOC:BHF", "GOC:bf" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000463 ; owl:annotatedTarget "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." . [] oboInOwl:hasDbXref "GOC:bf", "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000463 ; owl:annotatedTarget "positive regulation of EPSP" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000542 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000543 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gastrulation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000609 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of thyroid hormone generation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000610 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000611 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." . [] oboInOwl:source "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_11955 ; owl:annotatedTarget "KEGG:C03678" . [] oboInOwl:hasDbXref "PMID:21513708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000790 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Beilstein:606623" . [] oboInOwl:hasDbXref "PMID:21513708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000791 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." . [] oboInOwl:hasDbXref "PMID:21513708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000792 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "CAS:66-22-8" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000828 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000828 ; owl:annotatedTarget "regulation of PTH secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000828 ; owl:annotatedTarget "regulation of parathormone secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000828 ; owl:annotatedTarget "regulation of parathyrin secretion" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "CAS:66-22-8" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000829 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000829 ; owl:annotatedTarget "negative regulation of PTH secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000829 ; owl:annotatedTarget "negative regulation of parathormone secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000829 ; owl:annotatedTarget "negative regulation of parathyrin secretion" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "CAS:66-22-8" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000830 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000830 ; owl:annotatedTarget "positive regulation of PTH secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000830 ; owl:annotatedTarget "positive regulation of parathormone secretion" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2000830 ; owl:annotatedTarget "positive regulation of parathyrin secretion" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Gmelin:2896" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000831 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of steroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000832 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:11279060" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000833 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000834 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of androgen secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:12855717" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000835 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:15274295" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000836 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of androgen secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000843 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of testosterone secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:16834123" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000844 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000845 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of testosterone secretion." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_11955 ; owl:annotatedTarget "4-Amino-3-hydroxybutanoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000846 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000846 ; owl:annotatedTarget "regulation of corticosteroid secretion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:18533995" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000847 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000847 ; owl:annotatedTarget "negative regulation of corticosteroid secretion" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000848 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2000848 ; owl:annotatedTarget "positive regulation of corticosteroid secretion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:18815805" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000855 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:19175333" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000856 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000857 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22020693" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000858 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of aldosterone secretion." . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000859 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22074393" . [] oboInOwl:hasDbXref "GOC:sl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2000860 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22120518" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001151 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of renal water transport." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001152 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22171528" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001153 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of renal water transport." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001191 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22237209" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001191 ; owl:annotatedTarget "regulation of gamma-delta T cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001191 ; owl:annotatedTarget "regulation of gamma-delta T lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001191 ; owl:annotatedTarget "regulation of gamma-delta T-cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001191 ; owl:annotatedTarget "regulation of gamma-delta T-lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001192 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22299724" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001192 ; owl:annotatedTarget "negative regulation of gamma-delta T cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001192 ; owl:annotatedTarget "negative regulation of gamma-delta T lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001192 ; owl:annotatedTarget "negative regulation of gamma-delta T-cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001192 ; owl:annotatedTarget "negative regulation of gamma-delta T-lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001193 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002023 ; owl:annotatedTarget "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22356544" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001193 ; owl:annotatedTarget "positive regulation of gamma-delta T cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001193 ; owl:annotatedTarget "positive regulation of gamma-delta T lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001193 ; owl:annotatedTarget "positive regulation of gamma-delta T-cell activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001193 ; owl:annotatedTarget "positive regulation of gamma-delta T-lymphocyte activation during immune response" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001198 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22447672" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001199 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22483865" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001200 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001222 ; owl:annotatedTarget "Any process that modulates the frequency, rate or extent of neuron migration." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001222 ; owl:annotatedTarget "regulation of neuron chemotaxis" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001222 ; owl:annotatedTarget "regulation of neuronal migration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22567906" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001222 ; owl:annotatedTarget "regulation of neuron guidance" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001223 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001223 ; owl:annotatedTarget "negative regulation of neuron chemotaxis" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001223 ; owl:annotatedTarget "negative regulation of neuronal migration" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001223 ; owl:annotatedTarget "negative regulation of neuron guidance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:22685418" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001224 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of neuron migration." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001224 ; owl:annotatedTarget "positive regulation of neuron chemotaxis" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001224 ; owl:annotatedTarget "positive regulation of neuronal migration" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001224 ; owl:annotatedTarget "positive regulation of neuron guidance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "PMID:3654008" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001251 ; owl:annotatedTarget "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001251 ; owl:annotatedTarget "negative regulation of chromosome organisation" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001251 ; owl:annotatedTarget "negative regulation of chromosome organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001251 ; owl:annotatedTarget "negative regulation of maintenance of genome integrity" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001251 ; owl:annotatedTarget "negative regulation of nuclear genome maintenance" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Reaxys:606623" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:GO_2001252 ; owl:annotatedTarget "Any process that activates or increases the frequency, rate or extent of chromosome organization." . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:GO_2001252 ; owl:annotatedTarget "positive regulation of chromosome organisation" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001252 ; owl:annotatedTarget "positive regulation of chromosome organization and biogenesis" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001252 ; owl:annotatedTarget "positive regulation of maintenance of genome integrity" . [] oboInOwl:hasDbXref "GOC:obol" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:GO_2001252 ; owl:annotatedTarget "positive regulation of nuclear genome maintenance" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "URACIL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000002 ; owl:annotatedTarget "Deviation from the norm of height with respect to that which is expected according to age and gender norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000002 ; owl:annotatedTarget "Abnormality of body height" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000003 ; owl:annotatedTarget "Multicystic dysplasia of the kidney is characterized by multiple cysts of varying size in the kidney and the absence of a normal pelvicaliceal system. The condition is associated with ureteral or ureteropelvic atresia, and the affected kidney is nonfunctional." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000005 ; owl:annotatedTarget "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Uracil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000006 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000006 ; owl:annotatedTarget "monoallelic_autosomal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000006 ; owl:annotatedTarget "Autosomal dominant form" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000006 ; owl:annotatedTarget "Autosomal dominant type" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000007 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000007 ; owl:annotatedTarget "biallelic_autosomal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000007 ; owl:annotatedTarget "Autosomal recessive form" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "pyrimidine-2,4(1H,3H)-dione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000008 ; owl:annotatedTarget "An abnormality of the female internal genitalia." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "uracil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000009 ; owl:annotatedTarget "Dysfunction of the urinary bladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Repeated infections of the urinary tract." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Frequent urinary tract infections" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Recurrent UTIs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Repeated bladder infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Repeated urinary tract infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Urinary tract infections" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000010 ; owl:annotatedTarget "Urinary tract infections, recurrent" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "2,4(1H,3H)-pyrimidinedione" . [] oboInOwl:hasDbXref , "PMID:18095004", "PMID:22400020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000011 ; owl:annotatedTarget "A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000011 ; owl:annotatedTarget "Lack of bladder control due to nervous system injury" . [] oboInOwl:hasDbXref , "PMID:12559262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000012 ; owl:annotatedTarget "Urge incontinence is the strong, sudden need to urinate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000012 ; owl:annotatedTarget "Overactive bladder" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000012 ; owl:annotatedTarget "Urinary urgency" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "2,4-Dioxopyrimidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000013 ; owl:annotatedTarget "Underdevelopment of the uterus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000013 ; owl:annotatedTarget "Small uterus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000013 ; owl:annotatedTarget "Underdeveloped uterus" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "2,4-Pyrimidinedione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000014 ; owl:annotatedTarget "An abnormality of the urinary bladder." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "U" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000015 ; owl:annotatedTarget "Diverticulum (sac or pouch) in the wall of the urinary bladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000015 ; owl:annotatedTarget "Bladder diverticula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000016 ; owl:annotatedTarget "Inability to completely empty the urinary bladder during the process of urination." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000017 ; owl:annotatedTarget "Abnormally increased production of urine during the night leading to an unusually frequent need to urinate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000017 ; owl:annotatedTarget "Nycturia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000019 ; owl:annotatedTarget "Difficulty in beginning the process of urination." . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Ura" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000019 ; owl:annotatedTarget "Difficulty with flow" . [] oboInOwl:hasDbXref , "PMID:12559262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000020 ; owl:annotatedTarget "Loss of the ability to control the urinary bladder leading to involuntary urination." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000020 ; owl:annotatedTarget "Loss of bladder control" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17568 ; owl:annotatedTarget "Urazil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000021 ; owl:annotatedTarget "Dilatation of the bladder postnatally." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000022 ; owl:annotatedTarget "An abnormality of the male internal genitalia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000023 ; owl:annotatedTarget "Protrusion of the contents of the abdominal cavity through the inguinal canal." . [] a owl:Axiom ; rdfs:label "Inguinal hernia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000023 ; owl:annotatedTarget "MEDDRA:10022016" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000024 ; owl:annotatedTarget "The presence of inflammation of the prostate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000024 ; owl:annotatedTarget "Inflammation of the prostate" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_12109 ; owl:annotatedTarget "Beilstein:3937762" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000026 ; owl:annotatedTarget "Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000026 ; owl:annotatedTarget "Decreased function of male gonad" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Beilstein:635760" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "CAS:108-88-3" . [] oboInOwl:hasDbXref , "PMID:20514278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000027 ; owl:annotatedTarget "Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000027 ; owl:annotatedTarget "Absent sperm in semen" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000028 ; owl:annotatedTarget "Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "CAS:108-88-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000028 ; owl:annotatedTarget "Cryptorchism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000028 ; owl:annotatedTarget "Undescended testes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000028 ; owl:annotatedTarget "Undescended testis" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "CAS:108-88-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000029 ; owl:annotatedTarget "Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000029 ; owl:annotatedTarget "Testicular degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000030 ; owl:annotatedTarget "The presence of a gonadoblastoma of the testis." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Gmelin:2456" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000031 ; owl:annotatedTarget "The presence of inflammation of the epididymis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:11182169" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000032 ; owl:annotatedTarget "An abnormality of male external genitalia." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:11314682" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000033 ; owl:annotatedTarget "Ambiguous genitalia in an individual with XY genetic gender." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000033 ; owl:annotatedTarget "Ambiguous genitalia in males" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:11846266" . [] oboInOwl:hasDbXref "PMID:32644551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000034 ; owl:annotatedTarget "Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000035 ; owl:annotatedTarget "An anomaly of the testicle (the male gonad)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:11991009" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000035 ; owl:annotatedTarget "Abnormality of the testis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000036 ; owl:annotatedTarget "Abnormality of the penis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_12109 ; owl:annotatedTarget "5-amino-4-oxopentanoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:12062755" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000037 ; owl:annotatedTarget "Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In male pseudohermaphroditism, the genotype is male (XY) and the external genitalia are imcompletely virilized, ambiguous, or complete female. If gonads are present, they are testes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:12213539" . [] oboInOwl:hasDbXref , "PMID:23650202", "PMID:33085327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000039 ; owl:annotatedTarget "Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:12237258" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000040 ; owl:annotatedTarget "Enlarged penis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000040 ; owl:annotatedTarget "Long penis" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000041 ; owl:annotatedTarget "Ventral, lateral, or ventrolateral bowing of the shaft and glans penis of more than 30 degrees." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:12784113" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000042 ; owl:annotatedTarget "Lack of external genitalia in a male or female individual." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000042 ; owl:annotatedTarget "Absent external genitalia" . [] oboInOwl:hasDbXref , "PMID:23503957" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000044 ; owl:annotatedTarget "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:12876426" . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000046 ; owl:annotatedTarget "Apparently small scrotum for age." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:14512097" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000046 ; owl:annotatedTarget "Smaller than typical growth of scrotum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000046 ; owl:annotatedTarget "Underdeveloped scrotum" . [] oboInOwl:hasDbXref , "PMID:21968448" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000047 ; owl:annotatedTarget "Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:14559343" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000047 ; owl:annotatedTarget "Hypospadia" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000048 ; owl:annotatedTarget "Midline indentation or cleft of the scrotum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000048 ; owl:annotatedTarget "Cleft of scrotum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:14605898" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000049 ; owl:annotatedTarget "Superior margin of the scrotum superior to the base of the penis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000049 ; owl:annotatedTarget "Scrotum surrounds penis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000050 ; owl:annotatedTarget "Underdevelopment of part or all of the male external reproductive organs (which include the penis, the scrotum and the urethra)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15015825" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000050 ; owl:annotatedTarget "Small male external genitalia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000050 ; owl:annotatedTarget "Underdeveloped male genitalia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15019953" . [] oboInOwl:hasDbXref , "PMID:8097257" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000051 ; owl:annotatedTarget "Hypospadias with location of the urethral meatus in the perineal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000052 ; owl:annotatedTarget "Congenital anomaly characterized by closure or failure to develop an opening in the urethra in males." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15119846" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000053 ; owl:annotatedTarget "The presence of abnormally large testes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000053 ; owl:annotatedTarget "Large testis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15193425" . [] oboInOwl:hasDbXref , "PMID:15102623" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000054 ; owl:annotatedTarget "Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000054 ; owl:annotatedTarget "Short penis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15542760" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000054 ; owl:annotatedTarget "Small penis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000055 ; owl:annotatedTarget "An abnormality of the female external genitalia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000055 ; owl:annotatedTarget "Abnormal female external genitalia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15567510" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000056 ; owl:annotatedTarget "An abnormality of the clitoris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000056 ; owl:annotatedTarget "Abnormality of the clit" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15695158" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000058 ; owl:annotatedTarget "An anomaly of the labia, the externally visible portions of the vulva." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:15796064" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000059 ; owl:annotatedTarget "Undergrowth of the outer labia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000059 ; owl:annotatedTarget "Small labia majora" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000059 ; owl:annotatedTarget "Underdeveloped vaginal lips" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:16316648" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000060 ; owl:annotatedTarget "Developmental hypoplasia of the clitoris." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000060 ; owl:annotatedTarget "Small clitoris" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000060 ; owl:annotatedTarget "Underdeveloped clit" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:16348226" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000061 ; owl:annotatedTarget "Ambiguous genitalia in an individual with XX genetic gender." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000061 ; owl:annotatedTarget "Atypical appearance of female genitals" . [] oboInOwl:hasDbXref , "PMID:15102623" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000062 ; owl:annotatedTarget "A genital phenotype that is not clearly assignable to a single gender. Ambiguous genitalia can be evaluated using the Prader scale: Prader 0: Normal female external genitalia. Prader 1: Female external genitalia with clitoromegaly. Prader 2: Clitoromegaly with partial labial fusion forming a funnel-shaped urogenital sinus. Prader 3: Increased phallic enlargement. Complete labioscrotal fusion forming a urogenital sinus with a single opening. Prader 4: Complete scrotal fusion with urogenital opening at the base or on the shaft of the phallus. Prader 5: Normal male external genitalia. The diagnosis of ambiguous genitalia is made for Prader 1-4." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000062 ; owl:annotatedTarget "Ambiguous external genitalia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000062 ; owl:annotatedTarget "Ambiguous external genitalia at birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000062 ; owl:annotatedTarget "Intersex genitalia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:16601996" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000063 ; owl:annotatedTarget "Fusion of the labia minora as a result of labial adhesions resulting in vaginal obstruction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:17145141" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000063 ; owl:annotatedTarget "Fused inner lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000064 ; owl:annotatedTarget "Underdeveloped inner lips" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:17175136" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000065 ; owl:annotatedTarget "Enlargement of the labia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000065 ; owl:annotatedTarget "Enlargement of the vaginal lips" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:17497535" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000066 ; owl:annotatedTarget "Underdeveloped labia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:17725881" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000067 ; owl:annotatedTarget "Congenital anomaly characterized by closure or failure to develop an opening in the urethra in females." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:18397809" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000068 ; owl:annotatedTarget "Congenital anomaly characterized by closure or failure to develop an opening in the urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000069 ; owl:annotatedTarget "An abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:18832024" . [] oboInOwl:hasDbXref "eMedicine:453993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000070 ; owl:annotatedTarget "A ureterocele is a congenital saccular dilatation of the distal segment of the ureter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000071 ; owl:annotatedTarget "The presence of a stenotic, i.e., constricted ureter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000071 ; owl:annotatedTarget "Narrowing of the ureter" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19261054" . [] oboInOwl:hasDbXref , "PMID:33085364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000072 ; owl:annotatedTarget "The distention of the ureter with urine." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000072 ; owl:annotatedTarget "Swelling of ureter" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19384711" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000073 ; owl:annotatedTarget "A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000073 ; owl:annotatedTarget "Double ureter" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000074 ; owl:annotatedTarget "Blockage of urine flow from the renal pelvis to the proximal ureter." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19429395" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000075 ; owl:annotatedTarget "A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000075 ; owl:annotatedTarget "Extra kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000076 ; owl:annotatedTarget "Abnormal (retrograde) movement of urine from the bladder into ureters or kidneys related to inadequacy of the valvular mechanism at the ureterovesicular junction or other causes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19635754" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000077 ; owl:annotatedTarget "An abnormality of the kidney." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000077 ; owl:annotatedTarget "Abnormal kidney" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000077 ; owl:annotatedTarget "Abnormality of the kidney" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19765629" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "An abnormality of the genital system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "Genital abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "Genital abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "Genital anomalies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_12777 ; owl:annotatedTarget "vitamin A vitamer" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19825861" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "Genital defects" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000078 ; owl:annotatedTarget "Abnormality of the reproductive system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000079 ; owl:annotatedTarget "An abnormality of the urinary system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19928203" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000079 ; owl:annotatedTarget "Urinary tract abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000079 ; owl:annotatedTarget "Urinary tract abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000079 ; owl:annotatedTarget "Urinary tract anomalies" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:19969016" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000080 ; owl:annotatedTarget "An abnormal functionality of the genital system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000080 ; owl:annotatedTarget "Abnormality of genital physiology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000080 ; owl:annotatedTarget "Abnormality of reproductive system physiology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000080 ; owl:annotatedTarget "Genital functional abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:20347282" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000081 ; owl:annotatedTarget "A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000083 ; owl:annotatedTarget "A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:20837561" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000083 ; owl:annotatedTarget "Renal failure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000083 ; owl:annotatedTarget "Renal failure in adulthood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000085 ; owl:annotatedTarget "A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:21430649" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000085 ; owl:annotatedTarget "Horseshoe kidney" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000085 ; owl:annotatedTarget "Horseshoe kidneys" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000086 ; owl:annotatedTarget "A developmental defect in which a kidney is located in an abnormal anatomic position." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:21655021" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000086 ; owl:annotatedTarget "Abnormal kidney location" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000086 ; owl:annotatedTarget "Displaced kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000089 ; owl:annotatedTarget "Hypoplasia of the kidney." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:21731073" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000089 ; owl:annotatedTarget "Small kidneys" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000089 ; owl:annotatedTarget "Underdeveloped kidneys" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000090 ; owl:annotatedTarget "Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:21802510" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000091 ; owl:annotatedTarget "An abnormality of the renal tubules." . [] oboInOwl:hasDbXref , "PMID:27211375" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000092 ; owl:annotatedTarget "The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "PMID:21840036" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_12777 ; owl:annotatedTarget "vitamin A vitamers" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Reaxys:635760" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000093 ; owl:annotatedTarget "Increased levels of protein in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000093 ; owl:annotatedTarget "High urine protein levels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000093 ; owl:annotatedTarget "Protein in urine" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "UM-BBD_compID:c0114" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl", "PMID:18184729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000095 ; owl:annotatedTarget "A structural anomaly of the glomerulus." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "TOLUENE" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000096 ; owl:annotatedTarget "Accumulation of scar tissue within the glomerulus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer", "PMID:16164633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000097 ; owl:annotatedTarget "Segmental accumulation of scar tissue in individual (but not all) glomeruli." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Toluene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000098 ; owl:annotatedTarget "A height above that which is expected according to age and gender norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000098 ; owl:annotatedTarget "Increased body height" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000098 ; owl:annotatedTarget "Tall stature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "toluene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000099 ; owl:annotatedTarget "Inflammation of the renal glomeruli." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000100 ; owl:annotatedTarget "Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "toluene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000103 ; owl:annotatedTarget "An increased rate of urine production." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000103 ; owl:annotatedTarget "Increased urine output" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000104 ; owl:annotatedTarget "Agenesis, that is, failure of the kidney to develop during embryogenesis and development." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "toluene" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000104 ; owl:annotatedTarget "Absent kidney" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000104 ; owl:annotatedTarget "Missing kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000105 ; owl:annotatedTarget "An abnormal increase in the size of the kidney." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Toluen" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000105 ; owl:annotatedTarget "Enlarged kidney" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000105 ; owl:annotatedTarget "Large kidneys" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "Toluol" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000107 ; owl:annotatedTarget "A fluid filled sac in the kidney." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000107 ; owl:annotatedTarget "Kidney cyst" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000107 ; owl:annotatedTarget "Cystic kidney disease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000107 ; owl:annotatedTarget "Cystic kidneys" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000107 ; owl:annotatedTarget "Renal cysts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000108 ; owl:annotatedTarget "The presence of multiple cysts at the border between the renal cortex and medulla." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "methylbenzene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000110 ; owl:annotatedTarget "The presence of developmental dysplasia of the kidney." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000111 ; owl:annotatedTarget "Increased number and size of the juxtaglomerular cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000112 ; owl:annotatedTarget "A nonspecific term referring to disease or damage of the kidneys." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000112 ; owl:annotatedTarget "Kidney damage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_12777 ; owl:annotatedTarget "vitamin-A" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17578 ; owl:annotatedTarget "phenylmethane" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000112 ; owl:annotatedTarget "Kidney disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000113 ; owl:annotatedTarget "The presence of multiple cysts in both kidneys." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000114 ; owl:annotatedTarget "Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000117 ; owl:annotatedTarget "High urine phosphate in the presence of hypophosphatemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000118 ; owl:annotatedTarget "A phenotypic abnormality." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000119 ; owl:annotatedTarget "The presence of any abnormality of the genitourinary system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000119 ; owl:annotatedTarget "Abnormality of the GU system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000121 ; owl:annotatedTarget "Nephrocalcinosis is the deposition of calcium salts in renal parenchyma." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000121 ; owl:annotatedTarget "Too much calcium deposited in kidneys" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000121 ; owl:annotatedTarget "Increased calcium level in kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000122 ; owl:annotatedTarget "A unilateral form of agenesis of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000122 ; owl:annotatedTarget "Absent kidney on one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000122 ; owl:annotatedTarget "Missing one kidney" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000122 ; owl:annotatedTarget "Single kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000123 ; owl:annotatedTarget "The presence of inflammation affecting the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000123 ; owl:annotatedTarget "Kidney inflammation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000124 ; owl:annotatedTarget "Abnormal function of filtrating structures in kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000125 ; owl:annotatedTarget "A developmental defect in which a kidney is located in an abnormal anatomic position within the pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000125 ; owl:annotatedTarget "Sacral kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000126 ; owl:annotatedTarget "Severe distention of the kidney with dilation of the renal pelvis and calices." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000127 ; owl:annotatedTarget "A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000127 ; owl:annotatedTarget "Loss of salt in urine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000128 ; owl:annotatedTarget "High urine potassium in the presence of hypokalemia." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000128 ; owl:annotatedTarget "Renal K wasting" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000130 ; owl:annotatedTarget "An abnormality of the uterus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000130 ; owl:annotatedTarget "Abnormality of the uterus" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000130 ; owl:annotatedTarget "Uterine abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000130 ; owl:annotatedTarget "Uterine malformations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000131 ; owl:annotatedTarget "The presence of a leiomyoma of the uterus." . [] oboInOwl:hasDbXref , "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000132 ; owl:annotatedTarget "Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000132 ; owl:annotatedTarget "Abnormally heavy bleeding during menstruation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000132 ; owl:annotatedTarget "Abnormally heavy periods" . [] oboInOwl:hasDbXref "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000132 ; owl:annotatedTarget "Hypermenorrhea" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "Beilstein:1917416" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_12777 ; owl:annotatedTarget "vitamins A" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "CAS:7235-40-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000134 ; owl:annotatedTarget "Decreased functionality of the female gonads, i.e., of the ovary." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "CAS:7235-40-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000135 ; owl:annotatedTarget "A decreased functionality of the gonad." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000135 ; owl:annotatedTarget "Decreased activity of gonads" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000136 ; owl:annotatedTarget "The presence of a bifid uterus." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "CAS:7235-40-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000137 ; owl:annotatedTarget "An abnormality of the ovary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000137 ; owl:annotatedTarget "Abnormality of the ovaries" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000137 ; owl:annotatedTarget "Abnormality of the ovary" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "Drug_Central:345" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000137 ; owl:annotatedTarget "Ovarian disease" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000138 ; owl:annotatedTarget "The presence of one or more cysts of the ovary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000138 ; owl:annotatedTarget "Ovarian cyst" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070001" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000139 ; owl:annotatedTarget "The presence of prolapse of the uterus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000139 ; owl:annotatedTarget "Sagging uterus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11171227" . [] oboInOwl:hasDbXref , "PMID:23281358" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000140 ; owl:annotatedTarget "An abnormality of the ovulation cycle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000140 ; owl:annotatedTarget "Abnormality of the menstrual cycle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000140 ; owl:annotatedTarget "Menstrual abnormalities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11182771" . [] oboInOwl:hasDbXref "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000141 ; owl:annotatedTarget "Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000141 ; owl:annotatedTarget "Abnormal absence of menstruation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000142 ; owl:annotatedTarget "Any structural abnormality of the vagina." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11332447" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000143 ; owl:annotatedTarget "The presence of a fistula between the vagina and the rectum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11359610" . [] a owl:Axiom ; rdfs:label "Rectovaginal fistula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000143 ; owl:annotatedTarget "MEDDRA:10051097" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000143 ; owl:annotatedTarget "Abnormal connection between rectum and vagina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000144 ; owl:annotatedTarget "Abnormal fertility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000144 ; owl:annotatedTarget "Decreased fertility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002024 ; owl:annotatedTarget "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_131565 ; owl:annotatedTarget "steroid aldehydes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11382814" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000148 ; owl:annotatedTarget "Congenital occlusion of the vagina or adhesion of the walls of the vagina causing occlusion." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000148 ; owl:annotatedTarget "Abnormally closed or absent vagina" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11567548" . [] oboInOwl:hasDbXref , "eMedicine:986581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000149 ; owl:annotatedTarget "The presence of a gonadoblastoma of the ovary." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000150 ; owl:annotatedTarget "The presence of a gonadoblastoma, a neoplasm of a gonad that consists of aggregates of germ cells and sex cord elements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000151 ; owl:annotatedTarget "Aplasia of the uterus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11677037" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000151 ; owl:annotatedTarget "Absent uterus" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000151 ; owl:annotatedTarget "uterus absent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000152 ; owl:annotatedTarget "An abnormality of head and neck." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11714348" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000152 ; owl:annotatedTarget "Abnormality of head or neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000152 ; owl:annotatedTarget "Head and neck abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000153 ; owl:annotatedTarget "An abnormality of the mouth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:11962062" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000153 ; owl:annotatedTarget "Abnormal mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000153 ; owl:annotatedTarget "Abnormality of the mouth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000154 ; owl:annotatedTarget "Distance between the oral commissures more than 2 SD above the mean. Alternatively, an apparently increased width of the oral aperture (subjective)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:12081834" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000154 ; owl:annotatedTarget "Broad mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000154 ; owl:annotatedTarget "Large mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000154 ; owl:annotatedTarget "Large oral aperture" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000154 ; owl:annotatedTarget "Wide mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000155 ; owl:annotatedTarget "Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000155 ; owl:annotatedTarget "Mouth sore" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000155 ; owl:annotatedTarget "Mouth ulcer" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:12891827" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Any abnormality of the tongue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Abnormal tongue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Abnormality of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Glossal abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Lingual abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000157 ; owl:annotatedTarget "Tongue abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:14658721" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Increased length and width of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Glossal hypertrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Lingual hyperplasia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:14764912" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Lingual hypertrophy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Abnormally large tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Increased size of tongue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000158 ; owl:annotatedTarget "Large tongue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:14976384" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "An abnormality of the lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Abnormal lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Abnormality of the lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Lip abnormality" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Anomaly of lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Deformity of lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000159 ; owl:annotatedTarget "Malformation of lip" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_131604 ; owl:annotatedTarget "Mycoplasma genitalium metabolites" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:14997360" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000160 ; owl:annotatedTarget "Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000160 ; owl:annotatedTarget "Narrow mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000160 ; owl:annotatedTarget "Small mouth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15113067" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000161 ; owl:annotatedTarget "A type of cleft lip presenting as a midline (median) gap in the upper lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000161 ; owl:annotatedTarget "Central cleft upper lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15333155" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000162 ; owl:annotatedTarget "Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000162 ; owl:annotatedTarget "Posterior displacement of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000162 ; owl:annotatedTarget "Lingual retraction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000162 ; owl:annotatedTarget "Retraction of the tongue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15695449" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000163 ; owl:annotatedTarget "Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000163 ; owl:annotatedTarget "Abnormality of the oral cavity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15789045" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Any abnormality of the teeth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Abnormal dentition" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Abnormal teeth" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Dental abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Dental abnormality" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Dental anomalies" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15909543" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Abnormality of the teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Dental problem" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Dental problems" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000164 ; owl:annotatedTarget "Tooth abnormalities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15949680" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000166 ; owl:annotatedTarget "A severe form of periodontitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000166 ; owl:annotatedTarget "Severe gum disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000166 ; owl:annotatedTarget "Severe periodontal disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000166 ; owl:annotatedTarget "Severe pyorrhea" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:15949683" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000168 ; owl:annotatedTarget "Any abnormality of the gingiva (also known as gums)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000168 ; owl:annotatedTarget "Abnormality of the gums" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000169 ; owl:annotatedTarget "The presence of fibrosis of the gingiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000169 ; owl:annotatedTarget "Gingival fibrous nodules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000169 ; owl:annotatedTarget "Hereditary gingival fibromatosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000169 ; owl:annotatedTarget "Idiopathic gingival hyperplasia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:16036331" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000171 ; owl:annotatedTarget "Decreased length and width of the tongue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000171 ; owl:annotatedTarget "Abnormally small tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000171 ; owl:annotatedTarget "Underdevelopment of the tongue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:16087476" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000172 ; owl:annotatedTarget "Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000172 ; owl:annotatedTarget "Abnormality of palatine uvula" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000172 ; owl:annotatedTarget "Abnormality of the uvula" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:16338959" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000174 ; owl:annotatedTarget "Any abnormality of the palate, i.e., of roof of the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000174 ; owl:annotatedTarget "Abnormality of the palate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000174 ; owl:annotatedTarget "Abnormality of the roof of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000174 ; owl:annotatedTarget "Palatal anomaly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:16563447" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate)." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Cleft hard and soft palate" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Cleft of hard and soft palate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Cleft palate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:17004738" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Cleft roof of mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Palatoschisis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000175 ; owl:annotatedTarget "Uranostaphyloschisis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:17625873" . [] oboInOwl:hasDbXref , "PMID:19779505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000176 ; owl:annotatedTarget "Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000176 ; owl:annotatedTarget "Partial thickness cleft hard palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000177 ; owl:annotatedTarget "An abnormality of the upper lip." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:17708644" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000177 ; owl:annotatedTarget "Abnormality of upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000177 ; owl:annotatedTarget "Anomaly of the upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000177 ; owl:annotatedTarget "Deformity of the upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000177 ; owl:annotatedTarget "Malformation of the upper lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:17851775" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000178 ; owl:annotatedTarget "An abnormality of the lower lip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000178 ; owl:annotatedTarget "Abnormality of lower lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000178 ; owl:annotatedTarget "Anomaly of the lower lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000178 ; owl:annotatedTarget "Deformity of the lower lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000178 ; owl:annotatedTarget "Malformation of the lower lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:18429004" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Full lower lip vermilion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Increased height of lower lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Increased volume of lower lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Increased volume of lower lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Plump lower lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Prominent lower lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:18766464" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Prominent lower lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Thick red part of the lower lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Full lower lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000179 ; owl:annotatedTarget "Thick lower lip" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000180 ; owl:annotatedTarget "Multiple indentations and/or elevations on the edge and/or surface of the tongue producing an irregular surface contour." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000180 ; owl:annotatedTarget "Bumpy tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000180 ; owl:annotatedTarget "Lingual lobules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000182 ; owl:annotatedTarget "Abnormality of lingual movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000182 ; owl:annotatedTarget "Movement abnormality of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000183 ; owl:annotatedTarget "Difficulty in lingual movements" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:18767554" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000183 ; owl:annotatedTarget "Difficulty in tongue movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000183 ; owl:annotatedTarget "Hypokinesia of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000183 ; owl:annotatedTarget "Lingual hypokinesia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:18794175" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000185 ; owl:annotatedTarget "Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000185 ; owl:annotatedTarget "Cleft muscular palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000185 ; owl:annotatedTarget "Cleft of soft palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000185 ; owl:annotatedTarget "Cleft velum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_131619 ; owl:annotatedTarget "C27-steroids" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19480350" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000187 ; owl:annotatedTarget "Broad alveolar processes of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000187 ; owl:annotatedTarget "Wide alveolar margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000187 ; owl:annotatedTarget "Wide alveolar processes of jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000187 ; owl:annotatedTarget "Wide gum ridges" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19574250" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Decreased width of the upper lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Decreased height of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Decreased upper labial height" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Decreased upper labial length" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Decreased vertical length of upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Short upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Shortening of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000188 ; owl:annotatedTarget "Vertical deficiency of upper lip" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19669835" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000189 ; owl:annotatedTarget "Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000189 ; owl:annotatedTarget "Decreased palatal width" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000189 ; owl:annotatedTarget "Decreased transverse dimension of palate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19703237" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000189 ; owl:annotatedTarget "Narrow palate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000189 ; owl:annotatedTarget "Narrow roof of mouth" . [] oboInOwl:hasDbXref , "PMID:23633765" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000190 ; owl:annotatedTarget "An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19852884" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000190 ; owl:annotatedTarget "Abnormality of frenum of tongue" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000190 ; owl:annotatedTarget "Abnormality of lingual frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000190 ; owl:annotatedTarget "Abnormality of oral frenum" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000191 ; owl:annotatedTarget "Extra fold of tissue extending from the alveolar ridge to the inner surface of the upper or lower lip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000191 ; owl:annotatedTarget "Accessory oral frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000191 ; owl:annotatedTarget "Extra oral frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000191 ; owl:annotatedTarget "Supernumerary oral frenum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19888275" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000193 ; owl:annotatedTarget "Uvula separated into two parts most easily seen at the tip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000193 ; owl:annotatedTarget "Bifid palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000193 ; owl:annotatedTarget "Forked uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000193 ; owl:annotatedTarget "Split uvula" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19896667" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "A facial appearance characterized by a permanently or nearly permanently opened mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "Gaped jawed appearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "Gaped mouthed appearance" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "Open mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "Slack jawed appearance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:19937581" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000194 ; owl:annotatedTarget "Open mouth appearance" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000196 ; owl:annotatedTarget "Depression located on the vermilion of the lower lip, usually paramedian." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000197 ; owl:annotatedTarget "Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:20074992" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000197 ; owl:annotatedTarget "Anomaly of the parotid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Absence of parotid duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Failure of development of parotid duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Failure of development of stensen duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Missing parotid duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Missing stensen duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Agenesis of parotid duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000198 ; owl:annotatedTarget "Agenesis of stensen duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000199 ; owl:annotatedTarget "Lingual nodules" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:20515074" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "The presence of an abnormally short lingual frenulum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Hypoplasia of lingual frenulum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Hypoplasia of lingual frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Hypoplasia of tongue frenulum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22079732" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Hypoplasia of tongue frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Deficiency of lingual frenulum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Short lingual frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Short tongue frenum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000200 ; owl:annotatedTarget "Tight lingual frenulum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22309480" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000201 ; owl:annotatedTarget "Pierre Robin malformation is a sequence of developmental malformations characterized by micrognathia (mandibular hypoplasia), glossoptosis and cleft palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000201 ; owl:annotatedTarget "Pierre-robin anomaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000201 ; owl:annotatedTarget "Pierre-robin deformity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000201 ; owl:annotatedTarget "Pierre-robin malformation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22428124" . [] oboInOwl:hasDbXref , "PMID:21331089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000202 ; owl:annotatedTarget "The presence of a cleft in the oral cavity, the two main types of which are cleft lip and cleft palate. In cleft lip, there is the congenital failure of the maxillary and median nasal processes to fuse, forming a groove or fissure in the lip. In cleft palate, there is a congenital failure of the palate to fuse properly, forming a grooved depression or fissure in the roof of the mouth. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000202 ; owl:annotatedTarget "Cleft of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000204 ; owl:annotatedTarget "A gap in the upper lip. This is a congenital defect resulting from nonfusion of tissues of the lip during embryonal development." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22489215" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000204 ; owl:annotatedTarget "Cheiloschisis of upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000204 ; owl:annotatedTarget "Cleft upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000204 ; owl:annotatedTarget "Harelip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000204 ; owl:annotatedTarget "Cleft of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000205 ; owl:annotatedTarget "An abnormality of the appearance of the face caused by constant contraction of the lips leading to a puckered or pursed appearance." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000205 ; owl:annotatedTarget "Pursed lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000205 ; owl:annotatedTarget "Tightly closed lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000206 ; owl:annotatedTarget "Inflammation of the tongue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000206 ; owl:annotatedTarget "Inflammation of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000206 ; owl:annotatedTarget "Lingual inflammation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22534340" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000206 ; owl:annotatedTarget "Smooth swollen tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000207 ; owl:annotatedTarget "The presence of a triangular form of the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000207 ; owl:annotatedTarget "Triangular mouth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "PMID:22575730" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000207 ; owl:annotatedTarget "Triangular shaped mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000207 ; owl:annotatedTarget "Triangular shaped oral aperture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limitation in the ability to open the mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in jaw mobility" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in jaw movement" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in jaw opening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in mandibular mobility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in mandibular movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Decrease in mandibular opening" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited jaw mobility" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "Reaxys:1917416" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited jaw movement" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited jaw opening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited mandibular mobility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited mandibular opening" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Limited mouth opening" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Lockjaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000211 ; owl:annotatedTarget "Pain of muscles of mastication" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "BETA-CAROTENE" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000212 ; owl:annotatedTarget "Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000212 ; owl:annotatedTarget "Gingival enlargement" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000212 ; owl:annotatedTarget "Gum enlargement" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "beta,beta-carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the lips." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Labial telangiectasia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "beta-Carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Telangiectasia of the lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Angioectasias of the lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Labial angioectasias" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000214 ; owl:annotatedTarget "Spider veins of the lip" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_131621 ; owl:annotatedTarget "C19-steroids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene)" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Height of the vermilion of the upper lip in the midline more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the upper lip in the frontal view (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Full upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Full upper lip vermilion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Increased height of upper lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Increased volume of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Increased volume of upper lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Plump upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Prominent upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Thick upper lip" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "all-trans-beta-carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Prominent upper lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000215 ; owl:annotatedTarget "Thick red part of the upper lip" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "all-trans-beta-carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000217 ; owl:annotatedTarget "Dryness of the mouth due to salivary gland dysfunction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000217 ; owl:annotatedTarget "Decreased salivary flow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000217 ; owl:annotatedTarget "Dry mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000217 ; owl:annotatedTarget "Dry mouth syndrome" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17579 ; owl:annotatedTarget "beta-Karotin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000217 ; owl:annotatedTarget "Reduced salivation" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000218 ; owl:annotatedTarget "Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000218 ; owl:annotatedTarget "Elevated palate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17608 ; owl:annotatedTarget "D-aldohexoses" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000218 ; owl:annotatedTarget "High palate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000218 ; owl:annotatedTarget "Increased palatal height" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Height of the vermilion of the upper lip in the midline more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the upper lip in the frontal view (subjective)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Decreased height of upper lip vermilion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Decreased volume of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Decreased volume of upper lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Thin upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Thin red part of the upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000219 ; owl:annotatedTarget "Thin upper lips" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jhurst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000220 ; owl:annotatedTarget "Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000220 ; owl:annotatedTarget "Velopharyngeal dysfunction" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000220 ; owl:annotatedTarget "Velopharyngeal incompetence" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Accentuation of the grooves on the dorsal surface of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Fissured tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Grooved tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Lingua plicata" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Lingual furrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000221 ; owl:annotatedTarget "Plicated tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000222 ; owl:annotatedTarget "Hyperkeratosis of the gingiva." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17612 ; owl:annotatedTarget "UM-BBD_compID:c0272" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000223 ; owl:annotatedTarget "Abnormality of taste sensation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000224 ; owl:annotatedTarget "Decreased taste" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000224 ; owl:annotatedTarget "Decreased taste sensation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17612 ; owl:annotatedTarget "(3,4-dihydroxyphenyl)acetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000225 ; owl:annotatedTarget "Hemorrhage affecting the gingiva." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000225 ; owl:annotatedTarget "Bleeding gums" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000225 ; owl:annotatedTarget "Gingival haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000225 ; owl:annotatedTarget "Gingival hemorrhage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_131927 ; owl:annotatedTarget "dicarboxylic acids and derivatives" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17612 ; owl:annotatedTarget "3,4-dihydroxyphenylacetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000227 ; owl:annotatedTarget "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the tongue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17612 ; owl:annotatedTarget "homoprotocatechuate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000227 ; owl:annotatedTarget "Lingual telangiectasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000227 ; owl:annotatedTarget "Angioectasias of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000227 ; owl:annotatedTarget "Lingual angioectasias" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000227 ; owl:annotatedTarget "Spider veins of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000228 ; owl:annotatedTarget "Presence of telangiectases in the oral cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000228 ; owl:annotatedTarget "Angioectasias of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000228 ; owl:annotatedTarget "Angioectasias of the oral cavity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000228 ; owl:annotatedTarget "Spider veins of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000228 ; owl:annotatedTarget "Spider veins of the oral cavity" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "CAS:50-99-7" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "CAS:50-99-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000230 ; owl:annotatedTarget "Inflammation of the gingiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000230 ; owl:annotatedTarget "Gingival inflammation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000230 ; owl:annotatedTarget "Inflamed gums" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000230 ; owl:annotatedTarget "Red and swollen gums" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "D-gluco-hexose" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000232 ; owl:annotatedTarget "An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000232 ; owl:annotatedTarget "Drooping lower lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000232 ; owl:annotatedTarget "Eclabium of lower lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000232 ; owl:annotatedTarget "Outward turned lower lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000232 ; owl:annotatedTarget "Protruding lower lip" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000233 ; owl:annotatedTarget "Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000233 ; owl:annotatedTarget "Decreased volume of lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000233 ; owl:annotatedTarget "Decreased volume of lip vermillion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000233 ; owl:annotatedTarget "Thin lips" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "D-glucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000233 ; owl:annotatedTarget "Thin vermilion borders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000234 ; owl:annotatedTarget "An abnormality of the head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000234 ; owl:annotatedTarget "Abnormal head" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "D(+)-glucose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000234 ; owl:annotatedTarget "Abnormality of the head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000234 ; owl:annotatedTarget "Head abnormality" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "D-(+)-glucose" . [] oboInOwl:hasDbXref , "PMID:12825844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000235 ; owl:annotatedTarget "Any abnormality of the fontanelles (the regions covered by a thick membrane that normally ossify in the first two years of life) or the cranial sutures (the fibrous joints in which the articulating bones or cartilages of the skull are connected by sutural ligaments)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "Traubenzucker" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000236 ; owl:annotatedTarget "An abnormality of the anterior fontanelle, i.e., the cranial fontanelle that is located at the intersection of the coronal and sagittal sutures." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000236 ; owl:annotatedTarget "Abnormality of the forehead soft spot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000237 ; owl:annotatedTarget "Abnormally decreased size of the anterior fontanelle with respect to age-dependent norms." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "dextrose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000237 ; owl:annotatedTarget "Small forehead fontanel" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17634 ; owl:annotatedTarget "grape sugar" . [] oboInOwl:hasDbXref , "PMID:18211712", "PMID:19410151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000238 ; owl:annotatedTarget "Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000238 ; owl:annotatedTarget "Too much cerebrospinal fluid in the brain" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:23372317" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000239 ; owl:annotatedTarget "In newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000239 ; owl:annotatedTarget "Wide fontanelles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000239 ; owl:annotatedTarget "Large bregma sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000239 ; owl:annotatedTarget "Large, late-closing fontanelle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000239 ; owl:annotatedTarget "Wide bregma sutures" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:28580190" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000240 ; owl:annotatedTarget "Any abnormality of the size of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000240 ; owl:annotatedTarget "Abnormality of head size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000240 ; owl:annotatedTarget "Abnormality of cranium size" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000240 ; owl:annotatedTarget "Abnormality of skull size" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:30885572" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000242 ; owl:annotatedTarget "Parietal bossing is a marked prominence in the parietal region." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:33144142" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Triangular head shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Wedge shaped head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Triangular cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Triangular skull shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Wedge shaped cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000243 ; owl:annotatedTarget "Wedge shaped skull" . [] oboInOwl:hasDbXref "PMID:8460563" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000244 ; owl:annotatedTarget "Abnormal vertical height of the skull and a shortening of its anterior-posterior length, frequently combined with malformations of the occipital region." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:33973253" . [] oboInOwl:hasDbXref "PMID:8460563" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000244 ; owl:annotatedTarget "Brachy-turricephaly" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000244 ; owl:annotatedTarget "High, prominent forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000245 ; owl:annotatedTarget "Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "PMID:34606237" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000245 ; owl:annotatedTarget "Abnormality of the sinuses" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000245 ; owl:annotatedTarget "Abnormality of the sinuses of the head" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "anti-aging agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000246 ; owl:annotatedTarget "Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000246 ; owl:annotatedTarget "Sinus infection" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000246 ; owl:annotatedTarget "Sinus inflammation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000246 ; owl:annotatedTarget "Sinus disease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "anti-aging agents" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "An abnormality of skull shape characterized by a decreased anterior-posterior diameter. That is, a cephalic index greater than 81%. Alternatively, an apparently shortened anteroposterior dimension (length) of the head compared to width." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Broad cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Broad head shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Broad skull shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Wide cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Wide head shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "anti-aging drug" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Wide skull shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000248 ; owl:annotatedTarget "Short and broad skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000250 ; owl:annotatedTarget "An abnormal increase of density of the bones making up the calvaria." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132153 ; owl:annotatedTarget "hyaluronan" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "anti-aging drugs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000250 ; owl:annotatedTarget "Dense skull cap" . [] oboInOwl:hasDbXref "PMID:15806441", "PMID:19125436", "PMID:25465325", "PMID:9683597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Head circumference below 2 standard deviations below the mean for age and gender." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Abnormally small head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Decreased size of head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Small head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Small skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Abnormally small cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Abnormally small skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Decreased circumference of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Decreased size of cranium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "geroprotective agent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Decreased size of skull" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Reduced head circumference" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "Small head circumference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "small calvarium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000252 ; owl:annotatedTarget "small cranium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "geroprotective agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000253 ; owl:annotatedTarget "Progressive microcephaly is diagnosed when the head circumference falls progressively behind age- and gender-dependent norms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000253 ; owl:annotatedTarget "Microcephaly, progressive" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000253 ; owl:annotatedTarget "Progressively abnormally small cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000253 ; owl:annotatedTarget "Progressively abnormally small skull" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176497 ; owl:annotatedTarget "geroprotectors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000255 ; owl:annotatedTarget "An acute form of sinusitis." . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Big calvaria" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Big cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Big head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Big skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Increased size of head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Large calvaria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Large cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Large skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Increased size of cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Increased size of skull" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Large head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Large head circumference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000256 ; owl:annotatedTarget "Megacephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000260 ; owl:annotatedTarget "Enlargement of the anterior fontanelle with respect to age-dependent norms." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000260 ; owl:annotatedTarget "Wider-than-typical soft spot of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000260 ; owl:annotatedTarget "Large anterior fontanels" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tall head relative to width and length." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tall shaped head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tall shaped cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tall shaped skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tower cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000262 ; owl:annotatedTarget "Tower skull shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000263 ; owl:annotatedTarget "Oxycephaly (from Greek oxus, sharp, and kephalos, head) refers to a conical or pointed shape of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000264 ; owl:annotatedTarget "An abnormality of the mastoid process, which is the conical prominence projecting from the undersurface of the mastoid portion of the temporal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Asymmetry of the bones of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Asymmetry of head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Uneven head shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Asymmetry of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Cranial vault asymmetry" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Abnormality of cranial vault shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Abnormality of cranium shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132153 ; owl:annotatedTarget "hyaluronate polyanion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Abnormality of head shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Malformation of cranial vault shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Malformation of cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000267 ; owl:annotatedTarget "Malformation of head shape" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Beilstein:1354819" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "An abnormality of skull shape characterized by a increased anterior-posterior diameter, i.e., an increased antero-posterior dimension of the skull. Cephalic index less than 76%. Alternatively, an apparently increased antero-posterior length of the head compared to width. Often due to premature closure of the sagittal suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "Narrow cranium shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "Narrow head shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "Narrow skull shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "Long, narrow head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000268 ; owl:annotatedTarget "Tall and narrow skull" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "CAS:50-23-7" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Increased convexity of the occiput (posterior part of the skull)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Prominent back of the head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Prominent posterior head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Protruding back of the head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Prominent back of the skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Prominent posterior cranium" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "CAS:50-23-7" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Prominent posterior skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000269 ; owl:annotatedTarget "Protruding occiput" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000270 ; owl:annotatedTarget "Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "CAS:50-23-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000270 ; owl:annotatedTarget "Delayed closure of fontanels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000270 ; owl:annotatedTarget "Delayed cranial suture closure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "An abnormality of the face." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Drug_Central:1388" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Abnormality of the countenance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Abnormality of the physiognomy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Abnormality of the visage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Disorder of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Abnormal face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Abnormality of the face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Facial abnormality" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Disorder of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Anomaly of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Anomaly of the face" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02030001" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000271 ; owl:annotatedTarget "Facial anomaly" . [] oboInOwl:hasDbXref , , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Decreased size of malar bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "PMID:10438974" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Flat cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Underdevelopment of malar bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Zygomatic flattening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "Hypotrophic malar bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0000272 ; owl:annotatedTarget "The malar process is the most medial and superior portion of the bony midface, articulating with the maxilla and temporal and sphenoid bones, contiguous with the lateral boundary of the nasal bridge. The term malar hypoplasia is no longer preferred because surface examination cannot distinguish hypoplasia from hypotrophy." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000273 ; owl:annotatedTarget "Facial grimacing" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "PMID:2268561" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "A face that is short and narrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Facial hypoplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Hypoplasia of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Microface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Microfacies" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Short and narrow face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Small face" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "11beta,17,21-trihydroxypregn-4-ene-3,20-dione" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000274 ; owl:annotatedTarget "Small facies" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Decreased breadth of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:RO_0002025 ; owl:annotatedTarget "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Cortisol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Decreased horizontal dimension of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Decreased transverse dimension of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Decreased width of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Horizontal deficiency of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Horizontal hypoplasia of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Horizontal insufficiency of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Narrow face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Thin facies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Transverse deficiency of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Transverse hypoplasia of face" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "cortisol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Transverse insufficiency of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000275 ; owl:annotatedTarget "Thin face" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Facial height (length) is more than 2 standard deviations above the mean (objective); or, an apparent increase in the height (length) of the face (subjective)." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Elongation of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Increased height of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Increased length of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Increased vertical dimension of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Long face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Long facies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical Facial Excess" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical elongation of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical enlargement of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical excess of face" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical hyperplasia of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000276 ; owl:annotatedTarget "Vertical overgrowth of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Any abnormality of the mandible, the bone of the lower jaw." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Abnormality of the lower jaw bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Abnormality of the mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Anomaly of the mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Deformity of the lower jaw bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Deformity of the mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Malformation of the lower jaw bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000277 ; owl:annotatedTarget "Malformation of the mandible" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "11beta-hydrocortisone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "An abnormality in which the mandible is mislocalised posteriorly." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Receding chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Receding lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Retrognathia of lower jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Weak chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Weak jaw" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "17-hydroxycorticosterone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000278 ; owl:annotatedTarget "Retrogenia" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000280 ; owl:annotatedTarget "Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000280 ; owl:annotatedTarget "Coarse facial appearance" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "4-pregnen-11beta,17alpha,21-triol-3,20-dione" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000280 ; owl:annotatedTarget "Coarse facial features" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000280 ; owl:annotatedTarget "Rounded and heavy facial features" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000280 ; owl:annotatedTarget "Thickened facial skin with coarse facial features" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Hydrocortisone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000282 ; owl:annotatedTarget "Facial oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000282 ; owl:annotatedTarget "Facial puffiness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000282 ; owl:annotatedTarget "Facial swelling" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Kendall's compound F" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Bizygomatic (upper face) and bigonial (lower face) width greater than 2 standard deviations above the mean (objective); or an apparent increase in the width of the face (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Broad face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Broad facies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Horizontal excess of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Horizontal hyperplasia of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Increased breadth of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Increased horizontal dimension of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Increased transverse dimension of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Increased width of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Transverse excess of face" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_132362 ; owl:annotatedTarget "2-oxidopropane-1,2,3-tricarboxylate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "Reichstein's substance M" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Transverse hyperplasia of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Wide face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000283 ; owl:annotatedTarget "Wide facies" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "hidrocortisona" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000286 ; owl:annotatedTarget "A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000286 ; owl:annotatedTarget "Eye folds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000286 ; owl:annotatedTarget "Palpebronasal fold" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000286 ; owl:annotatedTarget "Plica palpebronasalis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000286 ; owl:annotatedTarget "Prominent eye folds" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "hydrocortisone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "An increased amount of subcutaneous fat tissue in the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Increased amount of facial adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Increased amount of facial fat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Increased volume of facial adipose tissue" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17650 ; owl:annotatedTarget "hydrocortisonum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Facial fat hyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Facial fat hypertrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Hyperplasia of facial adipose tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000287 ; owl:annotatedTarget "Hypertrophy of facial adipose tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "vitamin B9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000288 ; owl:annotatedTarget "An abnormality of the philtrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000288 ; owl:annotatedTarget "Abnormality of the infranasal depression" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "folate vitamer" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000289 ; owl:annotatedTarget "Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations above the mean, or alternatively, an apparently increased distance between the ridges of the philtrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000289 ; owl:annotatedTarget "Increased breadth of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000289 ; owl:annotatedTarget "Increased horizontal dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000289 ; owl:annotatedTarget "Increased transverse dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000289 ; owl:annotatedTarget "Increased width of philtrum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "folate vitamers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "An anomaly of the forehead." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "Abnormality of the forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "Abnormality of the frontal region of the face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "Anomaly of the forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "Deformity of the forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000290 ; owl:annotatedTarget "Malformation of the forehead" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "vitamin B-9" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000291 ; owl:annotatedTarget "Abnormality of facial fat" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "vitamin B9 vitamer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000291 ; owl:annotatedTarget "Deformity of facial adipose tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000291 ; owl:annotatedTarget "Malformation of facial adipose tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "vitamin B9 vitamers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000292 ; owl:annotatedTarget "Loss of normal subcutaneous fat tissue in the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000292 ; owl:annotatedTarget "Decreased amount of facial adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000292 ; owl:annotatedTarget "Decreased amount of facial fat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000292 ; owl:annotatedTarget "Decreased volume of facial adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000292 ; owl:annotatedTarget "Loss of facial fat" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132362 ; owl:annotatedTarget "2-oxido-1,2,3-propanetricarboxylate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176842 ; owl:annotatedTarget "vitamins B9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Increased prominence or roundness of soft tissues between zygomata and mandible." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Apple cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Big cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Full cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Increased size of cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Large cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Chubby cheeks" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_176843 ; owl:annotatedTarget "vitamin B12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Hyperplasia of cheeks" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Hypertrophy of cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000293 ; owl:annotatedTarget "Puffy cheeks" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000294 ; owl:annotatedTarget "Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000294 ; owl:annotatedTarget "Low frontal hairline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000294 ; owl:annotatedTarget "Low-set frontal hairline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000295 ; owl:annotatedTarget "A characteristic facial appearance with a round facial form, full cheeks, a short nose, and a relatively small chin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000295 ; owl:annotatedTarget "Doll-like facial appearance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176843 ; owl:annotatedTarget "vitamin B-12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000297 ; owl:annotatedTarget "Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000297 ; owl:annotatedTarget "Decreased facial muscle tone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000297 ; owl:annotatedTarget "Low facial muscle tone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000297 ; owl:annotatedTarget "Reduced facial muscle tone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000297 ; owl:annotatedTarget "Atony of facial musculature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176843 ; owl:annotatedTarget "vitamin B12 vitamer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000298 ; owl:annotatedTarget "A lack of facial expression often with staring eyes and a slightly open mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000298 ; owl:annotatedTarget "Expressionless face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000298 ; owl:annotatedTarget "Lack of facial expression" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000298 ; owl:annotatedTarget "Mask-like facial appearance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176843 ; owl:annotatedTarget "vitamin B12 vitamers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000300 ; owl:annotatedTarget "A face with a rounded and slightly elongated outline." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000300 ; owl:annotatedTarget "Oval face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000300 ; owl:annotatedTarget "Oval facial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000300 ; owl:annotatedTarget "Oval facies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_176843 ; owl:annotatedTarget "vitamins B12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000301 ; owl:annotatedTarget "An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000301 ; owl:annotatedTarget "Abnormality of facial muscles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000301 ; owl:annotatedTarget "Facial muscle issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Abnormal prominence of the chin related to increased length of the mandible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Hypertrophy of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Hypertrophy of mandible" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Big lower jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Increased projection of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Increased projection of mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Increased size of lower jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Large lower jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Prominent chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Prominent lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Prominent mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000303 ; owl:annotatedTarget "Increased size of mandible" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "An abnormality of the chin, i.e., of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "Abnormality of the chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "Abnormality of the menton" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "Anomaly of the chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "Deformity of the chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000306 ; owl:annotatedTarget "Malformation of the chin" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "A marked tapering of the lower face to the chin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "Pointed chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "Pointed mention region" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "Pointy chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "Small pointed chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000307 ; owl:annotatedTarget "Witch's chin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132362 ; owl:annotatedTarget "citric acid tetraanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000308 ; owl:annotatedTarget "A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000308 ; owl:annotatedTarget "Small retruded chin" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000309 ; owl:annotatedTarget "An anomaly of the midface, which is a region and not an anatomical term. It extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base. It is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region. Traditionally, the nose and premaxilla are not included in the midface." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000309 ; owl:annotatedTarget "Abnormality of the midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000309 ; owl:annotatedTarget "Deformity of the midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000309 ; owl:annotatedTarget "Malformation of the midface" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000311 ; owl:annotatedTarget "The facial appearance is more circular than usual as viewed from the front." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000311 ; owl:annotatedTarget "Circular face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000311 ; owl:annotatedTarget "Round face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000311 ; owl:annotatedTarget "Round facial appearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000311 ; owl:annotatedTarget "Round facial shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000315 ; owl:annotatedTarget "Abnormality of the eye region" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000315 ; owl:annotatedTarget "Abnormality of the region around the eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000315 ; owl:annotatedTarget "Anomaly of the orbital region of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000315 ; owl:annotatedTarget "Deformity of the orbital region of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000315 ; owl:annotatedTarget "Malformation of the orbital region of the face" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Beilstein:635685" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Excessive orbital separation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Increased distance between eye sockets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Increased distance between eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Wide-set eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000316 ; owl:annotatedTarget "Widely spaced eyes" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "CAS:56-81-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000317 ; owl:annotatedTarget "Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000317 ; owl:annotatedTarget "Involuntary facial quivering" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "CAS:56-81-5" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000319 ; owl:annotatedTarget "Flat skin surface, with no ridge formation in the central region of the upper lip between the nasal base and upper vermilion border." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000319 ; owl:annotatedTarget "Decreased depth of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000319 ; owl:annotatedTarget "Shallow philtrum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000320 ; owl:annotatedTarget "Bird-like facial appearance" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "CAS:56-81-5" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000321 ; owl:annotatedTarget "Facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000321 ; owl:annotatedTarget "Square face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000321 ; owl:annotatedTarget "Square facial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000321 ; owl:annotatedTarget "Square facies" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Drug_Central:1316" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000322 ; owl:annotatedTarget "Distance between nasal base and midline upper lip vermilion border more than 2 SD below the mean. Alternatively, an apparently decreased distance between nasal base and midline upper lip vermilion border." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000322 ; owl:annotatedTarget "Decreased height of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000322 ; owl:annotatedTarget "Decreased length of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000322 ; owl:annotatedTarget "Decreased vertical dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000322 ; owl:annotatedTarget "Vertical hypoplasia of philtrum" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Gmelin:26279" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "An abnormal difference between the left and right sides of the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Asymmetry of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Crooked face" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:11302662" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Facial asymmetry" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Unsymmetrical face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Unbalanced face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Unequal sides of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Uneven face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000324 ; owl:annotatedTarget "Uneven sides of face" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000325 ; owl:annotatedTarget "Facial contour, as viewed from the front, triangular in shape, with breadth at the temples and tapering to a narrow chin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000325 ; owl:annotatedTarget "Face with broad temples and narrow chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000325 ; owl:annotatedTarget "Triangular face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000325 ; owl:annotatedTarget "Triangular facial shape" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:11958517" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:11994365" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "An abnormality of the Maxilla (upper jaw bone)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Abnormality of the upper jaw bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Abnormality of the upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Anomaly of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Deformity of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Deformity of the upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Malformation of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000326 ; owl:annotatedTarget "Malformation of the upper jaw bones" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:12672239" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Deficiency of upper jaw bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Decreased size of maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Decreased size of upper jaw" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:12687625" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Hypoplasia of upper jaw bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Maxillary deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Maxillary hypoplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Maxillary micrognathia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Maxillary retrognathia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Maxillary retrusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Micromaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Small maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Small upper jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Small upper jaw bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:12689633" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Upper jaw deficiency" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Upper jaw retrusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Decreased projection of maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Decreased projection of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Hypotrophic maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Hypotrophic upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Retrognathia of upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000327 ; owl:annotatedTarget "Retrusion of upper jaw bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:12713573" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000329 ; owl:annotatedTarget "Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:14559393" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Decreased height of chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Short chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Short lower third of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Vertical deficiency of chin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000331 ; owl:annotatedTarget "Small chin" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000336 ; owl:annotatedTarget "Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:14563847" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000336 ; owl:annotatedTarget "Prominent brow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000336 ; owl:annotatedTarget "Prominent supraorbital margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000336 ; owl:annotatedTarget "Hyperplasia of supraorbital margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000336 ; owl:annotatedTarget "Hypertrophy of supraorbital margins" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132938 ; owl:annotatedTarget "ethylmalonate anion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:15026783" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Bitemporal widening" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Broad forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Increased width of the forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Intertemporal widening" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000337 ; owl:annotatedTarget "Wide forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000338 ; owl:annotatedTarget "A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000338 ; owl:annotatedTarget "Dull facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000338 ; owl:annotatedTarget "Hypomimia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:15342117" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000338 ; owl:annotatedTarget "Decreased facial expressions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000338 ; owl:annotatedTarget "Decreased facial muscle movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000339 ; owl:annotatedTarget "Coarse facial features reminiscent of those of a boxer." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000339 ; owl:annotatedTarget "Boxer-like facial appearance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000339 ; owl:annotatedTarget "Pugilistic facial appearance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:15786693" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000340 ; owl:annotatedTarget "Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000340 ; owl:annotatedTarget "Inclined forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000340 ; owl:annotatedTarget "Posteriorly sloping forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000340 ; owl:annotatedTarget "Receding forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000340 ; owl:annotatedTarget "Sloping forehead" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:15983192" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000341 ; owl:annotatedTarget "Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000341 ; owl:annotatedTarget "Decreased width of the forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000341 ; owl:annotatedTarget "Narrow forehead" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16244855" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Elongated philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Increased height of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Increased length of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Increased vertical dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000343 ; owl:annotatedTarget "Vertical hyperplasia of philtrum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16258193" . [] oboInOwl:hasDbXref , "PMID:856233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000346 ; owl:annotatedTarget "An abnormality of facial morphology characterized by a small mouth opening and constant contraction of the lips as if the patient were whistling." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000346 ; owl:annotatedTarget "Whistling appearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000346 ; owl:annotatedTarget "Whistling facial appearance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16319039" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Developmental hypoplasia of the mandible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Deficiency of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Hypoplasia of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Hypotrophic lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Hypotrophic mandible" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Little lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Lower jaw hypoplasia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Small jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Small lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Decreased projection of lower jaw" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16349488" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Decreased projection of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000347 ; owl:annotatedTarget "Retrusion of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000348 ; owl:annotatedTarget "An abnormally increased height of the forehead." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16475911" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000348 ; owl:annotatedTarget "High forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000348 ; owl:annotatedTarget "Tall forehead" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "Frontal hairline with bilateral arcs to a low point in the midline of the forehead." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "Hairline peak" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "Hairline point" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "Pointed hairline at front of head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "V-shaped frontal hairline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000349 ; owl:annotatedTarget "Widow's peak" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16651733" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "The presence of a forehead that is abnormally small." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "Decreased size of forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "Decreased size of frontal region of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "Small forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "Hypoplasia of forehead" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132938 ; owl:annotatedTarget "ethylmalonic acid anion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16664750" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000350 ; owl:annotatedTarget "Hypotrophic forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "An abnormality of the external ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "Abnormality of the external ear" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "Abnormality of the outer ear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "Ear anomalies" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "External ear malformations" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000356 ; owl:annotatedTarget "Outer ear abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000357 ; owl:annotatedTarget "Abnormal location of the ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000357 ; owl:annotatedTarget "Abnormal location of ears" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000358 ; owl:annotatedTarget "A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000358 ; owl:annotatedTarget "Ears rotated toward back of head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000359 ; owl:annotatedTarget "An abnormality of the inner ear." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000359 ; owl:annotatedTarget "Abnormality of the inner ear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000359 ; owl:annotatedTarget "Inner ear abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000360 ; owl:annotatedTarget "Ringing in ears" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000360 ; owl:annotatedTarget "Ringing in the ears" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19184438" . [] oboInOwl:hasDbXref , "PMID:15931303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000362 ; owl:annotatedTarget "In otosclerosis, a callus of bone accumulates on the stapes creating a partial fixation. This limits the movement of the stapes bone, which results in hearing loss." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19231894" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000363 ; owl:annotatedTarget "An abnormality of the lobule of pinna." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000363 ; owl:annotatedTarget "Abnormal earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000363 ; owl:annotatedTarget "Abnormality of ear lobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000363 ; owl:annotatedTarget "Abnormality of earlobe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19460032" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000364 ; owl:annotatedTarget "An abnormality of the sensory perception of sound." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000364 ; owl:annotatedTarget "Abnormal hearing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000364 ; owl:annotatedTarget "Hearing abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19548674" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000365 ; owl:annotatedTarget "A decreased magnitude of the sensory perception of sound." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000365 ; owl:annotatedTarget "Deafness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000365 ; owl:annotatedTarget "Hearing defect" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000365 ; owl:annotatedTarget "Hearing impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000365 ; owl:annotatedTarget "Hearing loss" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19795216" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "An abnormality of the nose." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Abnormality of the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Anomaly of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Nasal abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:19956799" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Nasal anomaly" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Deformity of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Malformation of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Nasal deformity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000366 ; owl:annotatedTarget "Nasal malformation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000368 ; owl:annotatedTarget "Ears that are low-set and posteriorly rotated." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:22705534" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000369 ; owl:annotatedTarget "Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000369 ; owl:annotatedTarget "Low set ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000369 ; owl:annotatedTarget "Low-set ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000369 ; owl:annotatedTarget "Lowset ears" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:23562176" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000370 ; owl:annotatedTarget "An abnormality of the middle ear." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:23747440" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000371 ; owl:annotatedTarget "Acute otitis media is a short and generally painful infection of the middle ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000371 ; owl:annotatedTarget "Acute middle ear infection" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000372 ; owl:annotatedTarget "An abnormality of the External acoustic tube (also known as the auditory canal)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:24835191" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000375 ; owl:annotatedTarget "An abnormality of the cochlea." . [] oboInOwl:hasDbXref , "PMID:21849370", "PMID:34698066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000376 ; owl:annotatedTarget "With incomplete partition II, the cochlea consists of 1.5 turns; the apical and middle cochlea turns are undifferentiated and form a cystic apex. The vestibule is normal while the vestibular aqueduct is always enlarged. Developmental arrest occurs at the seventh week of gestation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000377 ; owl:annotatedTarget "An abnormality of the pinna, which is also referred to as the auricle or external ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000377 ; owl:annotatedTarget "Abnormally shaped ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000377 ; owl:annotatedTarget "Auricular malformation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000377 ; owl:annotatedTarget "Deformed ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000377 ; owl:annotatedTarget "Malformed ears" . [] oboInOwl:hasDbXref , "PMID:19162421", "PMID:22073081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000378 ; owl:annotatedTarget "Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000378 ; owl:annotatedTarget "Cup-shaped ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000378 ; owl:annotatedTarget "Cupped ear" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:558160" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000378 ; owl:annotatedTarget "Simple, cup-shaped ears" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000378 ; owl:annotatedTarget "Cupped ears" . [] oboInOwl:hasDbXref , "PMID:12089654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000381 ; owl:annotatedTarget "Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000383 ; owl:annotatedTarget "Abnormality of the region around the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000383 ; owl:annotatedTarget "Anomaly of the periauricular region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000383 ; owl:annotatedTarget "Deformity of the periauricular region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000383 ; owl:annotatedTarget "Malformation of the periauricular region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "A rudimentary tag of skin often containing ear tissue including a core of cartilage and located just anterior to the auricle (outer part of the ear)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "Skin tag in front of the ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "Skin tag on the posterior cheek" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:6299616" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "Ear tag" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "Preauricular acrochordon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000384 ; owl:annotatedTarget "Preauricular fibroepithelial polyp" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:7031247" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000385 ; owl:annotatedTarget "Reduced volume of the earlobe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000385 ; owl:annotatedTarget "Small earlobe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000385 ; owl:annotatedTarget "Small earlobes" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_132939 ; owl:annotatedTarget "Reaxys:3904851" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "PMID:7392035" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000387 ; owl:annotatedTarget "Absence of fleshy non-cartilaginous tissue inferior to the tragus and incisura." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000387 ; owl:annotatedTarget "Absent earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000387 ; owl:annotatedTarget "Earlobe, absent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000387 ; owl:annotatedTarget "Lobeless ears" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Reaxys:635685" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000388 ; owl:annotatedTarget "Inflammation or infection of the middle ear." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "UM-BBD_compID:c0066" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000388 ; owl:annotatedTarget "Middle ear infection" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "GLYCEROL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000389 ; owl:annotatedTarget "Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000389 ; owl:annotatedTarget "Chronic infections of the middle ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000389 ; owl:annotatedTarget "Otitis media, chronic" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000389 ; owl:annotatedTarget "Chronic middle ear infection" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Glycerol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000391 ; owl:annotatedTarget "Increased thickness of the helix of the ear." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000394 ; owl:annotatedTarget "Anterior and inferior folding of the upper portion of the ear that obliterates triangular fossa and scapha." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycerol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000395 ; owl:annotatedTarget "The presence of an abnormally prominent antihelix." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000396 ; owl:annotatedTarget "A condition in which the helix is folded over to a greater degree than normal. That is, excessive curling of the helix edge, whereby the free edge is parallel to the plane of the ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000396 ; owl:annotatedTarget "Overfolded ears" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000399 ; owl:annotatedTarget "A form of sensorineural deafness with either congenital onset or infantile onset, i.e., before the acquisition of speech." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycerol" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000400 ; owl:annotatedTarget "Median longitudinal ear length greater than two standard deviations above the mean and median ear width greater than two standard deviations above the mean (objective); or, apparent increase in length and width of the pinna (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000400 ; owl:annotatedTarget "Large ears" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "propane-1,2,3-triol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000402 ; owl:annotatedTarget "An abnormal narrowing of the external auditory canal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000402 ; owl:annotatedTarget "Narrow ear canal" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000402 ; owl:annotatedTarget "Narrowing of passageway from outer ear to middle ear" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "1,2,3-Propanetriol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000403 ; owl:annotatedTarget "Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000403 ; owl:annotatedTarget "Otitis media, recurrent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000403 ; owl:annotatedTarget "Recurrent middle ear infection" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "1,2,3-Trihydroxypropane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000405 ; owl:annotatedTarget "An abnormality of vibrational conductance of sound to the inner ear leading to impairment of sensory perception of sound." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000405 ; owl:annotatedTarget "Conductive deafness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000405 ; owl:annotatedTarget "Conductive hearing loss" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_132939 ; owl:annotatedTarget "ethylpropanedioate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Glycerin" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Glyceritol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000407 ; owl:annotatedTarget "A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000407 ; owl:annotatedTarget "Hearing loss, sensorineural" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000408 ; owl:annotatedTarget "A progressive form of sensorineural hearing impairment." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Glyzerin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000410 ; owl:annotatedTarget "A type of hearing loss resulting from a combination of conductive hearing impairment and sensorineural hearing impairment." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000410 ; owl:annotatedTarget "Hearing loss, mixed" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000410 ; owl:annotatedTarget "Mixed hearing impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000410 ; owl:annotatedTarget "Mixed hearing loss" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Gro" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000411 ; owl:annotatedTarget "Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000411 ; owl:annotatedTarget "Prominent ear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000411 ; owl:annotatedTarget "Prominent ears" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000411 ; owl:annotatedTarget "Protruding ears" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Oelsuess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000413 ; owl:annotatedTarget "Absence or failure to form of the external auditory canal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000413 ; owl:annotatedTarget "Absent ear canal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000413 ; owl:annotatedTarget "Atresia of the external auditory canals" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Propanetriol" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000414 ; owl:annotatedTarget "Increased volume and globular shape of the anteroinferior aspect of the nose." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000414 ; owl:annotatedTarget "Bulbous nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000414 ; owl:annotatedTarget "Potato nose" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "Trihydroxypropane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000415 ; owl:annotatedTarget "Abnormality of the choanae (the posterior nasal apertures)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycerine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000417 ; owl:annotatedTarget "Slender nose" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000418 ; owl:annotatedTarget "Decreased width of the nasal ridge." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000418 ; owl:annotatedTarget "Decreased width of nasal ridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000418 ; owl:annotatedTarget "Narrow nasal ridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000418 ; owl:annotatedTarget "Pinched nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000418 ; owl:annotatedTarget "Thin nasal ridge" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycerol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000419 ; owl:annotatedTarget "An abnormality of the nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000419 ; owl:annotatedTarget "Abnormality of septum of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000419 ; owl:annotatedTarget "Abnormality of the nasal septum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000419 ; owl:annotatedTarget "Anomaly of nasal septum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000419 ; owl:annotatedTarget "Anomaly of septum of nose" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycerolum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000420 ; owl:annotatedTarget "Reduced superior to inferior length of the nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000420 ; owl:annotatedTarget "Decreased length of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000420 ; owl:annotatedTarget "Decreased length of septum of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000420 ; owl:annotatedTarget "Short nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000420 ; owl:annotatedTarget "Short septum of nose" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17754 ; owl:annotatedTarget "glycyl alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Bloody nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Frequent nosebleeds" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Nasal haemorrhage" . [] oboInOwl:hasDbXref "NCIT:C26766" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Nasal hemorrhage" . [] oboInOwl:hasDbXref "NCIT:C26766" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Nose bleed" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Nose bleeding" . [] oboInOwl:hasDbXref "NCIT:C26766" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000421 ; owl:annotatedTarget "Nosebleed" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "CAS:535-34-2" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Abnormality of the bridge of the nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Abnormality of the nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Deformity of the bridge of the nose" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "CAS:535-34-2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Deformity of the nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Malformation of the bridge of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000422 ; owl:annotatedTarget "Malformation of the nasal bridge" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "PMID:12907234" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Anterior positioning of the nasal root in comparison to the usual positioning for age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Elevated nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "High nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Prominent bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Prominent nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Prominent nasal root" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Protruding bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Protruding nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Convex bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000426 ; owl:annotatedTarget "Convex nasal bridge" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "PMID:15033753" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "An abnormality of the Ala of nose." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "Abnormality of the nasal alar cartilage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "Deformity of the nasal ala" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "PMID:22212096" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "Deformity of the nasal alar cartilage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "Malformation of the nasal ala" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000429 ; owl:annotatedTarget "Malformation of the nasal alar cartilage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000430 ; owl:annotatedTarget "Thinned, deficient, or excessively arched ala nasi." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000430 ; owl:annotatedTarget "Decreased size of nasal alae" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000430 ; owl:annotatedTarget "Small nasal alae" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000430 ; owl:annotatedTarget "Underdeveloped tissue around nostril" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "Reaxys:2416815" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Increased breadth of the nasal bridge (and with it, the nasal root)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Broad nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Broad nasal root" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Broadened nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Increased breadth of bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Increased breadth of nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Increased width of bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Increased width of nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Nasal bridge broad" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Wide bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Wide nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Widened nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000431 ; owl:annotatedTarget "Broad flat nasal bridge" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132941 ; owl:annotatedTarget "2-hydroxyglutarate anion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "Cystathionine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000433 ; owl:annotatedTarget "Abnormality of mucosa of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000433 ; owl:annotatedTarget "Abnormality of mucous membrane of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000433 ; owl:annotatedTarget "Abnormality of nasal mucous membrane" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000433 ; owl:annotatedTarget "Abnormality of the nasal mucosa" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "S-(2-amino-2-carboxyethyl)homocysteine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Telangiectasia of the nasal mucosa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Angioectasia of mucosa of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Angioectasia of mucous membrane of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Angioectasia of nasal mucous membrane" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "DL-Cystathionine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Nasal mucous membrane telangiectasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Spider veins of mucosa of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Spider veins of mucous membrane of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Spider veins of nasal mucous membrane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Telangiectasia of mucosa of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Telangiectasia of mucous membrane of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000434 ; owl:annotatedTarget "Telangiectasia of nasal mucous membrane" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17755 ; owl:annotatedTarget "cystathione" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "An abnormality of the nasal tip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Abnormality of the nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Abnormality of tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Deformity of the nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Deformity of tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Malformation of the nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000436 ; owl:annotatedTarget "Malformation of tip of nose" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Decreased distance from the nasal tip to the nasal base." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Caved in nasal tip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Depressed nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Depressed tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Flat nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Flat tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Flattened nasal tip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Nasal tip, depressed" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000437 ; owl:annotatedTarget "Retruded tip of nose" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Beaked nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Beaklike protrusion" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "Beilstein:2224615" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Convex dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Convex nasal dorsum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Hooked nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000444 ; owl:annotatedTarget "Polly beak nasal deformity" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "CAS:434-16-2" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Broad nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Increased breadth of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Increased nasal breadth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Increased nasal width" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Increased width of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000445 ; owl:annotatedTarget "Wide nose" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "CAS:434-16-2" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Decreased width of the bony bridge of the nose." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Narrow bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Narrow nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Nasal Bridge, Narrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Nasal bridge, thin" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "CAS:434-16-2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Pinched bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000446 ; owl:annotatedTarget "Pinched nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000447 ; owl:annotatedTarget "Pear-shaped nose" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132941 ; owl:annotatedTarget "2-hydroxyglutaric acid anion" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "Gmelin:893079" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Big nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Disproportionately large nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Increased nasal size" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Increased size of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Large nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Prominent nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Pronounced nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Hyperplasia of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Hypertrophy of nose" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST01010069" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Nasal hyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000448 ; owl:annotatedTarget "Nasal hypertrophy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000451 ; owl:annotatedTarget "Triangular nasal tip" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "Cholesta-5,7-dien-3beta-ol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000451 ; owl:annotatedTarget "Triangular shaped tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000452 ; owl:annotatedTarget "Abnormal narrowing of the choana (the posterior nasal aperture)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000452 ; owl:annotatedTarget "Narrowing of the rear opening of the nasal cavity" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "cholesta-5,7-dien-3beta-ol" . [] oboInOwl:hasDbXref , "PMID:4996574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000453 ; owl:annotatedTarget "Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000453 ; owl:annotatedTarget "Blockage of the rear opening of the nasal cavity" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "(3beta)-cholesta-5,7-dien-3-ol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000454 ; owl:annotatedTarget "Flared nostrils" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "5,7-cholestadien-3-beta-ol" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Increase in width of the nasal tip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Broad nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Broad tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Broad, upturned nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Increased breadth of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Increased breadth of tip of nose" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "5,7-cholestadien-3beta-ol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Increased width of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Increased width of tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Nasal tip, broad" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Nasal tip, wide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Wide tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000455 ; owl:annotatedTarget "Broad upturned nose" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "7-Dehydrocholesterol" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "Bifid tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "Cleft nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "Cleft tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "Notched nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000456 ; owl:annotatedTarget "Notched tip of nose" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "7-dehydrocholesterol" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Depressed dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Depressed nasal dorsum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Flat dorsum of nose" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17759 ; owl:annotatedTarget "Provitamin D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Flat nasal dorsum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Flat nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Recessed dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Recessed nasal dorsum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Recessed nasal ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Retruded dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Retruded nasal dorsum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000457 ; owl:annotatedTarget "Retruded nasal ridge" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "LIPID_MAPS_class:LMSP02" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000458 ; owl:annotatedTarget "An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000458 ; owl:annotatedTarget "Lost smell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "PMID:7542630" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000460 ; owl:annotatedTarget "Interalar distance more than 2 SD below the mean for age, or alternatively, an apparently decreased width of the nasal base and alae." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000460 ; owl:annotatedTarget "Decreased nasal breadth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000460 ; owl:annotatedTarget "Decreased nasal width" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000460 ; owl:annotatedTarget "Narrow nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000460 ; owl:annotatedTarget "Thin nose" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "Ceramide" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Nasal tip, upturned" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Upturned nares" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Upturned nasal tip" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "Cer" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Upturned nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Upturned nostrils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000463 ; owl:annotatedTarget "Upturned nasal tips" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "N-acylated sphingoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000464 ; owl:annotatedTarget "An abnormality of the neck." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000464 ; owl:annotatedTarget "Abnormality of the neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000464 ; owl:annotatedTarget "Anomaly of the neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000464 ; owl:annotatedTarget "Deformity of the neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000464 ; owl:annotatedTarget "Malformation of the neck" . [] oboInOwl:hasDbXref , "PMID:24523736" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000465 ; owl:annotatedTarget "Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000465 ; owl:annotatedTarget "Neck webbing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000465 ; owl:annotatedTarget "Webbed neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000466 ; owl:annotatedTarget "Limited cervical range of motion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000466 ; owl:annotatedTarget "Limited neck range of motion" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "a ceramide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000467 ; owl:annotatedTarget "Decreased strength of the neck musculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000467 ; owl:annotatedTarget "Floppy neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000467 ; owl:annotatedTarget "Neck muscle weakness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17761 ; owl:annotatedTarget "ceramides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000467 ; owl:annotatedTarget "Flaccid neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000468 ; owl:annotatedTarget "An increased amount of subcutaneous fat tissue around the neck." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000468 ; owl:annotatedTarget "Increased fat around the neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Diminished length of the neck." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Cervical shortening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Decreased cervical height" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Decreased cervical length" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Decreased length of neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000470 ; owl:annotatedTarget "Short neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000471 ; owl:annotatedTarget "Dysplasia affecting the vasculature of the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000471 ; owl:annotatedTarget "GI angiodysplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Increased inferior-superior length of the neck." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Cervical elongation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Elongated neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Increased cervical length" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Increased length of neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000472 ; owl:annotatedTarget "Long neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000473 ; owl:annotatedTarget "Involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000473 ; owl:annotatedTarget "Loxia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000473 ; owl:annotatedTarget "Wry neck" . [] oboInOwl:hasDbXref , "PMID:16100637", "PMID:30431620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000474 ; owl:annotatedTarget "A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold (NF) measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. An NF measurement greater than 5 mm at 14 to 17+6 weeks of gestation, or 6 mm at 18 to 28 weeks has been associated with a markedly increased risk for Down syndrome." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000474 ; owl:annotatedTarget "Thickened nuchal skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000474 ; owl:annotatedTarget "Thickened skin folds of neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000474 ; owl:annotatedTarget "Thickened skin over the neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000475 ; owl:annotatedTarget "Increased side-to-side width of the neck." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000475 ; owl:annotatedTarget "Broad neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000475 ; owl:annotatedTarget "Increased width of neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000475 ; owl:annotatedTarget "Wide neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000475 ; owl:annotatedTarget "Thick neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000476 ; owl:annotatedTarget "A cystic lymphatic lesion of the neck." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Beilstein:1098229" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000478 ; owl:annotatedTarget "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000478 ; owl:annotatedTarget "Abnormal eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000478 ; owl:annotatedTarget "Abnormality of the eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000478 ; owl:annotatedTarget "Eye disease" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "CAS:67-56-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000479 ; owl:annotatedTarget "A structural abnormality of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000479 ; owl:annotatedTarget "Abnormal retina" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000479 ; owl:annotatedTarget "Retina issue" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "CAS:67-56-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000480 ; owl:annotatedTarget "A notch or cleft of the retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000480 ; owl:annotatedTarget "Hole in the back of the eye" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "CAS:67-56-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000481 ; owl:annotatedTarget "Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000482 ; owl:annotatedTarget "A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000482 ; owl:annotatedTarget "Cornea of eye less than 10mm in diameter" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Gmelin:449" . [] oboInOwl:hasDbXref , , "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000483 ; owl:annotatedTarget "A type of astigmatism associated with abnormal curvatures on the anterior and/or posterior surface of the cornea." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000483 ; owl:annotatedTarget "Abnormal curving of the cornea or lens of the eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000483 ; owl:annotatedTarget "Astigmatism" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:11141607" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000484 ; owl:annotatedTarget "A form of astigmatism in which one meridian is hyperopic while the one at a right angle to it has no refractive error." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000485 ; owl:annotatedTarget "An enlargement of the cornea with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000485 ; owl:annotatedTarget "Enlarged cornea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "ethanedioic acid anion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:11430978" . [] oboInOwl:hasDbXref , , "PMID:26319345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000486 ; owl:annotatedTarget "A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000486 ; owl:annotatedTarget "Cross-eyed" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000486 ; owl:annotatedTarget "Squint" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:11489599" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000486 ; owl:annotatedTarget "Squint eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000488 ; owl:annotatedTarget "Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000488 ; owl:annotatedTarget "Noninflammatory retina disease" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:11680737" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000490 ; owl:annotatedTarget "An eye that is more deeply recessed into the plane of the face than is typical." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000490 ; owl:annotatedTarget "Deep set eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000490 ; owl:annotatedTarget "Deep-set eyes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:11684179" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000490 ; owl:annotatedTarget "Deeply set eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000490 ; owl:annotatedTarget "Sunken eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000491 ; owl:annotatedTarget "Inflammation of the cornea." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000491 ; owl:annotatedTarget "Corneal inflammation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:14012711" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000492 ; owl:annotatedTarget "An abnormality of the eyelids." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000492 ; owl:annotatedTarget "Abnormality of the eyelid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000492 ; owl:annotatedTarget "Abnormality of the eyelids" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:14678513" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000493 ; owl:annotatedTarget "An abnormality of the fovea centralis, the central area of the macula that mediates central, high resolution vision and contains the largest concentration of cone cells in the retina." . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000494 ; owl:annotatedTarget "The palpebral fissure inclination is more than two standard deviations below the mean." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:14760634" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000494 ; owl:annotatedTarget "Downslanting palpebral fissures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000494 ; owl:annotatedTarget "Downward slanting of the opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000494 ; owl:annotatedTarget "Downward slanting palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000495 ; owl:annotatedTarget "The presence of recurrent corneal epithelial erosions. Although most corneal epithelial defects heal quickly, some may show recurrent ulcerations." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000495 ; owl:annotatedTarget "Recurrent breakdown of clear protective layer of eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000495 ; owl:annotatedTarget "Recurrent corneal ulcerations" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:15172721" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "An abnormality in voluntary or involuntary eye movements or their control." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Abnormal eye movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Abnormal eye movements" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Abnormal motility of the globe of the eye" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Abnormal movement of the globe of the eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Abnormality of eye movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Eye movement abnormalities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:15906011" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000496 ; owl:annotatedTarget "Eye movement issue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:16705261" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000498 ; owl:annotatedTarget "Inflammation of the eyelids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000498 ; owl:annotatedTarget "Cellulitis of eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000498 ; owl:annotatedTarget "Inflammation of eyelids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "ethanedioic acid anions" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:17451998" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000499 ; owl:annotatedTarget "An abnormality of the eyelashes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000499 ; owl:annotatedTarget "Abnormal eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000499 ; owl:annotatedTarget "Abnormality of the eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000499 ; owl:annotatedTarget "Eyelash abnormality" . [] oboInOwl:hasDbXref , "PMID:11815354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000501 ; owl:annotatedTarget "Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:17733096" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000502 ; owl:annotatedTarget "An abnormality of the conjunctiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000503 ; owl:annotatedTarget "The presence of an increased number of twists and turns of the conjunctival blood vessels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:19064074" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000504 ; owl:annotatedTarget "Abnormality of eyesight (visual perception)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000504 ; owl:annotatedTarget "Abnormality of sight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000504 ; owl:annotatedTarget "Abnormality of vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000504 ; owl:annotatedTarget "Vision issue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:19850112" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000505 ; owl:annotatedTarget "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000505 ; owl:annotatedTarget "Impaired vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000505 ; owl:annotatedTarget "Loss of eyesight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000505 ; owl:annotatedTarget "Poor vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000505 ; owl:annotatedTarget "Visual impairment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "PMID:20314698" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000506 ; owl:annotatedTarget "Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000506 ; owl:annotatedTarget "Corners of eye widely separated" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000506 ; owl:annotatedTarget "Increased distance between medial canthi" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000506 ; owl:annotatedTarget "Increased intercanthal distance" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Reaxys:1098229" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000508 ; owl:annotatedTarget "The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000508 ; owl:annotatedTarget "Drooping upper eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000508 ; owl:annotatedTarget "Eyelid ptosis" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "UM-BBD_compID:c0132" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000508 ; owl:annotatedTarget "Eye drop" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "METHANOL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000509 ; owl:annotatedTarget "Inflammation of the conjunctiva." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000509 ; owl:annotatedTarget "Pink eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000509 ; owl:annotatedTarget "Conjunctivitis, recurrent" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Methanol" . [] oboInOwl:hasDbXref , "PMID:20212494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000510 ; owl:annotatedTarget "An inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones." . [] oboInOwl:hasDbXref , "PMID:20671861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000511 ; owl:annotatedTarget "A supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000512 ; owl:annotatedTarget "Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000514 ; owl:annotatedTarget "An abnormally slow velocity of the saccadic eye movements." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000514 ; owl:annotatedTarget "Slow eye movements" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000514 ; owl:annotatedTarget "Slow visual tracking" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "methanol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000517 ; owl:annotatedTarget "An abnormality of the lens." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000517 ; owl:annotatedTarget "Abnormality of the lens" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000517 ; owl:annotatedTarget "Lens issue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "oxalate anion" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "methanol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000517 ; owl:annotatedTarget "Lens disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000518 ; owl:annotatedTarget "A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000518 ; owl:annotatedTarget "Clouding of the lens of the eye" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "CH3OH" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000518 ; owl:annotatedTarget "Cloudy lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000519 ; owl:annotatedTarget "A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000519 ; owl:annotatedTarget "Clouding of the lens of the eye at birth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "MeOH" . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "An eye that is protruding anterior to the plane of the face to a greater extent than is typical." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "Bulging eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "Eyeballs bulging out" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "Prominent eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "Prominent globes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000520 ; owl:annotatedTarget "Protruding eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000522 ; owl:annotatedTarget "Absence of tear secretion." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000522 ; owl:annotatedTarget "Absence of tears in the eyes" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000522 ; owl:annotatedTarget "Absent lacrimal fluids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000522 ; owl:annotatedTarget "Absent tear secretion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Methyl alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000523 ; owl:annotatedTarget "A cataract that affects the region of the lens directly beneath the capsule of the lens." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "Methylalkohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000524 ; owl:annotatedTarget "The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000524 ; owl:annotatedTarget "Small dilated blood vessels near membrane covering front of eye and eyelids" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "carbinol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000525 ; owl:annotatedTarget "An abnormality of the iris, which is the pigmented muscular tissue between the cornea and the lens, that is perforated by an opening called the pupil." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000525 ; owl:annotatedTarget "Abnormality of the iris" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "spirit of wood" . [] oboInOwl:hasDbXref , , "PMID:24138039", "PMID:25313118", "PMID:29850208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000526 ; owl:annotatedTarget "Abnormality of the iris characterized by, typically bilateral, complete or partial iris hypoplasia. The phenotype ranges from mild defects of anterior iris stroma only to almost complete absence of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000526 ; owl:annotatedTarget "Absent iris" . [] oboInOwl:hasDbXref "PMID:19125427", "PMID:26288407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000527 ; owl:annotatedTarget "Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "wood alcohol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000527 ; owl:annotatedTarget "Increased length of eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000527 ; owl:annotatedTarget "Long eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000527 ; owl:annotatedTarget "Unusually long eyelashes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "wood naphtha" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Absence of the globe or eyeball." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Absence of eyeballs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Absence of globes of eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Failure of development of eyeball" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Missing eyeball" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Missing globe of eye" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "No eyeball" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "No globe of eye" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000528 ; owl:annotatedTarget "Ocular absence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "A reduction of previously attained ability to see." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17790 ; owl:annotatedTarget "wood spirit" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Progressive loss of vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Progressive vision loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Progressive visual impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Slowly progressive visual loss" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Vision loss, progressive" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Visual loss, progressive" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000529 ; owl:annotatedTarget "Decreased visual acuity, progressive" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "oxalate anions" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:13752799" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:4303459" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000532 ; owl:annotatedTarget "An abnormality of the choroid and retina." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:4622133" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:4753431" . [] oboInOwl:hasDbXref , "PMID:20224472" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000533 ; owl:annotatedTarget "Atrophy of the choroid and retinal layers of the fundus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:4798212" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000534 ; owl:annotatedTarget "An abnormality of the eyebrow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000534 ; owl:annotatedTarget "Abnormality of the eyebrow" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000537 ; owl:annotatedTarget "A fold of skin starting at or just below the medial aspect of the lower lid and arching upward to cover, extend in front of and lateral to the medial canthus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000538 ; owl:annotatedTarget "Apparent optic disc swelling in the absence of increased intracranial pressure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000539 ; owl:annotatedTarget "An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000540 ; owl:annotatedTarget "An abnormality of refraction characterized by the ability to see objects in the distance clearly, while objects nearby appear blurry." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000540 ; owl:annotatedTarget "Farsightedness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000540 ; owl:annotatedTarget "Long-sightedness" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:4957953" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000541 ; owl:annotatedTarget "Separation of the inner layers of the retina (neural retina) from the pigment epithelium." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000541 ; owl:annotatedTarget "Detached retina" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000541 ; owl:annotatedTarget "Retinal detachment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:5790329" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000542 ; owl:annotatedTarget "Reduced ability to move the eye in the direction of the nose." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000543 ; owl:annotatedTarget "A pale yellow discoloration of the optic disk (the area of the optic nerve head in the retina). The optic disc normally has a pinkish hue with a central yellowish depression." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000543 ; owl:annotatedTarget "Disc pallor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000543 ; owl:annotatedTarget "Pale optic discs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "Paralysis of the external ocular muscles." . [] oboInOwl:hasDbXref , , ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "CPEO" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "Chronic progressive external ophthalmoplegia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "Paralysis or weakness of muscles within or surrounding outer part of eye" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "Progressive paralysis or weakness of muscles of eye motility" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000544 ; owl:annotatedTarget "Progressive paralysis or weakness of muscles of eye movement" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "PMID:6078089" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000545 ; owl:annotatedTarget "An abnormality of refraction characterized by the ability to see objects nearby clearly, while objects in the distance appear blurry." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000545 ; owl:annotatedTarget "Close sighted" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000545 ; owl:annotatedTarget "Near sighted" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000545 ; owl:annotatedTarget "Near sightedness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000545 ; owl:annotatedTarget "Nearsightedness" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "a phenolic steroid" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000546 ; owl:annotatedTarget "A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000546 ; owl:annotatedTarget "Retina degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000549 ; owl:annotatedTarget "Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000550 ; owl:annotatedTarget "Lack of any response to stimulation upon electroretinography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "An anomaly in the ability to discriminate between or recognize colors." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Abnormal color vision" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Abnormal colour vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Abnormality of color vision" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_177917 ; owl:annotatedTarget "phenolic steroids" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Colour vision defect" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Disturbed colour vision" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Color vision defect, severe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Color vision defects" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Colour vision defect, severe" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Colour vision defects" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000551 ; owl:annotatedTarget "Loss in colour vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000552 ; owl:annotatedTarget "Difficulty distinguishing between yellow and blue, possible related to dysfunction of the S photopigment." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000552 ; owl:annotatedTarget "Blue yellow color blindness" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000552 ; owl:annotatedTarget "Blue yellow colour blindness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "oxalates" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17792 ; owl:annotatedTarget "RX" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000552 ; owl:annotatedTarget "Blue/yellow color vision defect" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000552 ; owl:annotatedTarget "Blue/yellow colour vision defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000553 ; owl:annotatedTarget "An abnormality of the uvea, the vascular layer of the eyeball." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17792 ; owl:annotatedTarget "RX" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17792 ; owl:annotatedTarget "organic halide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000554 ; owl:annotatedTarget "Inflammation of one or all portions of the uveal tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000555 ; owl:annotatedTarget "An abnormal white reflection from the pupil rather than the usual black reflection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000555 ; owl:annotatedTarget "Leukokoria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000555 ; owl:annotatedTarget "White pupillary reflex" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17792 ; owl:annotatedTarget "organic halides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000556 ; owl:annotatedTarget "Retinal dystrophy is an abnormality of the retina associated with a hereditary process. Retinal dystrophies are defined by their predominantly monogenic inheritance and they are frequently associated with loss or dysfunction of photoreceptor cells as a primary or secondary event." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000556 ; owl:annotatedTarget "Breakdown of light-sensitive cells in back of eye" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/buphthalmos" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000557 ; owl:annotatedTarget "Enlarged eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000558 ; owl:annotatedTarget "A congenital malformation of the anterior segment characterized by iridicorneal malformation, glaucoma, iris stroma hypoplasia, posterior embryotoxon, and corneal opacities." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17792 ; owl:annotatedTarget "organohalogen compounds" . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000561 ; owl:annotatedTarget "Lack of eyelashes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000561 ; owl:annotatedTarget "Absent eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000561 ; owl:annotatedTarget "Failure of development of eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000561 ; owl:annotatedTarget "Agenesis of eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000561 ; owl:annotatedTarget "Aplasia of eyelashes" . [] oboInOwl:hasDbXref , "PMID:7767020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000563 ; owl:annotatedTarget "A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000563 ; owl:annotatedTarget "Bulging cornea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000563 ; owl:annotatedTarget "Conical cornea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000564 ; owl:annotatedTarget "A developmental disorder of the lacrimal drainage system that most often affects the lacrimal ostium and resulting in non-opening of the nasolacrimal duct. It usually results from a non-canalization of the nasolacrimal duct." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000564 ; owl:annotatedTarget "Unopened tear duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000565 ; owl:annotatedTarget "A form of strabismus with one or both eyes turned inward ('crossed') to a relatively severe degree, usually defined as 10 diopters or more." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000565 ; owl:annotatedTarget "Inward turning cross eyed" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000567 ; owl:annotatedTarget "Absence of a region of the retina, retinal pigment epithelium, and choroid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000567 ; owl:annotatedTarget "Birth defect that causes a hole in the innermost layer at the back of the eye" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "oxalic acid anion" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "Beilstein:1721402" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000568 ; owl:annotatedTarget "A developmental anomaly characterized by abnormal smallness of one or both eyes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000568 ; owl:annotatedTarget "Decreased size of eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000568 ; owl:annotatedTarget "Decreased size of globe of eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000568 ; owl:annotatedTarget "Abnormally small eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000568 ; owl:annotatedTarget "Abnormally small globe of eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000570 ; owl:annotatedTarget "An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements." . [] oboInOwl:hasDbXref , "PMID:572501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000571 ; owl:annotatedTarget "Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "CAS:302-84-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000572 ; owl:annotatedTarget "Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000572 ; owl:annotatedTarget "Loss of vision" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000572 ; owl:annotatedTarget "Vision loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000572 ; owl:annotatedTarget "Visual loss" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "CAS:302-84-1" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000573 ; owl:annotatedTarget "Hemorrhage occurring within the retina." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000573 ; owl:annotatedTarget "Retinal bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000573 ; owl:annotatedTarget "Retinal haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000573 ; owl:annotatedTarget "Retinal haemorrhages" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000573 ; owl:annotatedTarget "Retinal hemorrhages" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "CAS:302-84-1" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Increased density/number and/or increased diameter of eyebrow hairs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Bushy eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Dense eyebrow" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "Gmelin:26429" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Heavy eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Prominent eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Thick eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Thick eyebrows" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000574 ; owl:annotatedTarget "Hypertrichosis of the eyebrows" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000575 ; owl:annotatedTarget "A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000575 ; owl:annotatedTarget "Blind spot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000576 ; owl:annotatedTarget "A scotoma (area of diminished vision within the visual field) located between the central point of fixation and the blind spot with a roughly horizontal oval shape." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000577 ; owl:annotatedTarget "A form of strabismus with one or both eyes deviated outward." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000577 ; owl:annotatedTarget "Outward facing eye ball" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "Reaxys:1721402" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000579 ; owl:annotatedTarget "Blockage of the lacrimal duct." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000579 ; owl:annotatedTarget "Blocked tear duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000580 ; owl:annotatedTarget "An abnormality of the retina characterized by pigment deposition. It is typically associated with migration and proliferation of macrophages or retinal pigment epithelial cells into the retina; melanin from these cells causes the pigmentary changes. Pigmentary retinopathy is a common final pathway of many retinal conditions and is often associated with visual loss." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "Serine" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000581 ; owl:annotatedTarget "A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000581 ; owl:annotatedTarget "Decreased width of palpebral fissure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000581 ; owl:annotatedTarget "Narrow opening between the eyelids" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "serine" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000582 ; owl:annotatedTarget "The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000582 ; owl:annotatedTarget "Upward slanting of the opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000582 ; owl:annotatedTarget "Upslanted palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000585 ; owl:annotatedTarget "An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea, leading to decreased vision, foreign body sensation, and ocular irritation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "2-Amino-3-hydroxypropionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000586 ; owl:annotatedTarget "Reduced depth of the orbits associated with prominent-appearing ocular globes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000586 ; owl:annotatedTarget "Decreased depth of eye sockets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000586 ; owl:annotatedTarget "Decreased depth of orbits" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000586 ; owl:annotatedTarget "Shallow eye sockets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000586 ; owl:annotatedTarget "Small shallow orbits" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "2-amino-3-hydroxypropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000587 ; owl:annotatedTarget "Abnormality of the optic nerve." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000587 ; owl:annotatedTarget "Optic nerve issue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132952 ; owl:annotatedTarget "oxalic acid anions" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "3-Hydroxyalanine" . [] oboInOwl:hasDbXref , "PMID:16219745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000588 ; owl:annotatedTarget "A cleft of the optic nerve that extends inferiorly." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17822 ; owl:annotatedTarget "Serin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000589 ; owl:annotatedTarget "A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000589 ; owl:annotatedTarget "Notched pupil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000590 ; owl:annotatedTarget "Initial bilateral ptosis followed by limitation of eye movements in all directions and slowing of saccades." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000591 ; owl:annotatedTarget "An abnormality of the sclera." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000591 ; owl:annotatedTarget "Abnormality of the outer white part of eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000592 ; owl:annotatedTarget "An abnormal bluish coloration of the sclera." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000592 ; owl:annotatedTarget "Blue outer white part of eyeball" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000592 ; owl:annotatedTarget "Grey sclerae" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000592 ; owl:annotatedTarget "Whites of eyes are a bluish-gray color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000592 ; owl:annotatedTarget "Whites of eyes are a bluish-gray colour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000593 ; owl:annotatedTarget "Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000594 ; owl:annotatedTarget "Reduced depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is decreased." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000597 ; owl:annotatedTarget "Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000597 ; owl:annotatedTarget "Weakness of extraocular eye movement" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000597 ; owl:annotatedTarget "Weakness of muscles controlling eye movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000598 ; owl:annotatedTarget "An abnormality of the ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000598 ; owl:annotatedTarget "Abnormality of the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000599 ; owl:annotatedTarget "An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000599 ; owl:annotatedTarget "Abnormality of hairline at front of head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000599 ; owl:annotatedTarget "Abnormality of the frontal hairline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000600 ; owl:annotatedTarget "An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly." . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Abnormally close eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Closely spaced eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Decreased distance between eye sockets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Decreased distance between eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Decreased interpupillary distance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000601 ; owl:annotatedTarget "Decreased orbital separation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000602 ; owl:annotatedTarget "Paralysis of one or more extraocular muscles that are responsible for eye movements." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000602 ; owl:annotatedTarget "Eye muscle paralysis" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000602 ; owl:annotatedTarget "Paralysis of extraocular eye movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000603 ; owl:annotatedTarget "An area of depressed vision located at the point of fixation and that interferes with central vision." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000603 ; owl:annotatedTarget "Blind spot located at fixation point" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000603 ; owl:annotatedTarget "Central blind spot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000605 ; owl:annotatedTarget "A supranuclear gaze palsy is an inability to look in a particular direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "An abnormality of the region situated around the orbit of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "Abnormality of the region around the eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "Abnormality of the region around the eye socket" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "Anomaly of the periorbital region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "Deformity of the periorbital region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000606 ; owl:annotatedTarget "Malformation of the periorbital region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000607 ; owl:annotatedTarget "Periorbital rhytids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000607 ; owl:annotatedTarget "Wrinkles around the eyes" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000608 ; owl:annotatedTarget "A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Beilstein:2227647" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000609 ; owl:annotatedTarget "Underdevelopment of the optic nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000609 ; owl:annotatedTarget "Underdeveloped optic nerves" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "CAS:32222-06-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000610 ; owl:annotatedTarget "Any structural abnormality of the choroid." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "CAS:32222-06-3" . [] oboInOwl:hasDbXref , "PMID:19369671" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000612 ; owl:annotatedTarget "A coloboma of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000612 ; owl:annotatedTarget "Cat eye" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Drug_Central:466" . [] oboInOwl:hasDbXref , , , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000613 ; owl:annotatedTarget "Extreme sensitivity of the eyes to light" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000613 ; owl:annotatedTarget "Light hypersensitivity" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000613 ; owl:annotatedTarget "Photodysphoria" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST03020258" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000614 ; owl:annotatedTarget "An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000615 ; owl:annotatedTarget "An abnormality of the pupil." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:10217585" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000615 ; owl:annotatedTarget "Abnormality of the pupil" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000615 ; owl:annotatedTarget "Pupillary abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000615 ; owl:annotatedTarget "Pupillary abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:15928596" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000616 ; owl:annotatedTarget "Abnormal (non-physiological) constriction of the pupil." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000616 ; owl:annotatedTarget "Constricted pupils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000616 ; owl:annotatedTarget "Pupillary constriction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000617 ; owl:annotatedTarget "An abnormality of eye movement characterized by impaired smooth-pursuit eye movements." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "decanedioic acid anion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:19429426" . [] oboInOwl:hasDbXref , "PMID:28779882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000618 ; owl:annotatedTarget "Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degrees in radius around central fixation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000618 ; owl:annotatedTarget "Blindness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000618 ; owl:annotatedTarget "Legal blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000619 ; owl:annotatedTarget "Reduced ability to turn the eyes inward in order to focus on a nearby object." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000620 ; owl:annotatedTarget "Inflammation of the nasolacrimal sac." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/dacryocystitis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000620 ; owl:annotatedTarget "Infection of the lacrimal sac" . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000621 ; owl:annotatedTarget "An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000621 ; owl:annotatedTarget "Eyelid folded in" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000621 ; owl:annotatedTarget "Eyelid turned in" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:20599255" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000621 ; owl:annotatedTarget "Inverted eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000622 ; owl:annotatedTarget "Lack of sharpness of vision resulting in the inability to see fine detail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000622 ; owl:annotatedTarget "Blurred vision" . [] oboInOwl:hasDbXref , "PMID:20629667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000623 ; owl:annotatedTarget "A vertical gaze palsy with inability to direct the gaze of the eyes downwards." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:22905919" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000625 ; owl:annotatedTarget "A short discontinuity of the margin of the lower or upper eyelid." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000625 ; owl:annotatedTarget "Cleft eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000625 ; owl:annotatedTarget "Full thickness defect of the eyelid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000625 ; owl:annotatedTarget "Notched eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000627 ; owl:annotatedTarget "A posterior embryotoxon is the presence of a prominent and anteriorly displaced line of Schwalbe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000629 ; owl:annotatedTarget "Increase in periorbital soft tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000629 ; owl:annotatedTarget "Puffiness around eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000629 ; owl:annotatedTarget "Fullness around the eyes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:23103122" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:23144765" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000630 ; owl:annotatedTarget "Abnormality of retinal arteries" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000630 ; owl:annotatedTarget "Retinal arterial abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000631 ; owl:annotatedTarget "The presence of an increased number of twists and turns of the retinal artery." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "PMID:6687801" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000632 ; owl:annotatedTarget "Abnormality of tear production." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000632 ; owl:annotatedTarget "Abnormality of tear production" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000633 ; owl:annotatedTarget "Abnormally decreased lacrimation, that is, reduced ability to produce tears." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000633 ; owl:annotatedTarget "Decreased tear secretion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000634 ; owl:annotatedTarget "An impaired ability of the eye to move in the outward direction (towards the side of the head)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000635 ; owl:annotatedTarget "A markedly blue coloration of the iris." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000635 ; owl:annotatedTarget "Blue eyes" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Reaxys:2227647" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000636 ; owl:annotatedTarget "A short discontinuity of the margin of the upper eyelid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000636 ; owl:annotatedTarget "Cleft upper eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000636 ; owl:annotatedTarget "Full thickness defect of the upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000636 ; owl:annotatedTarget "Notched upper eyelid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Broad opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Broad palpebral fissure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Long opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Long palpebral fissures" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Calcitriol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Wide opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000637 ; owl:annotatedTarget "Wide palpebral fissure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000639 ; owl:annotatedTarget "Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "calcitriol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000639 ; owl:annotatedTarget "Involuntary, rapid, rhythmic eye movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000640 ; owl:annotatedTarget "Nystagmus made apparent by looking to the right or to the left." . [] oboInOwl:hasDbXref , "PMID:572501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000641 ; owl:annotatedTarget "The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000641 ; owl:annotatedTarget "Dysmetric eye movements" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000641 ; owl:annotatedTarget "Uncoordinated eye movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000642 ; owl:annotatedTarget "Difficulty with discriminating red and green hues." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000642 ; owl:annotatedTarget "Red green color blindness" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000642 ; owl:annotatedTarget "Red green colour blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000642 ; owl:annotatedTarget "Red/green color vision defect" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000642 ; owl:annotatedTarget "Red/green colour vision defect" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "decanedioic acid anions" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000643 ; owl:annotatedTarget "A focal dystonia that affects the muscles of the eyelids and brow, associated with involuntary recurrent spasm of both eyelids." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000643 ; owl:annotatedTarget "Eyelid spasm" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000643 ; owl:annotatedTarget "Eyelid twitching" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000643 ; owl:annotatedTarget "Involuntary closure of eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000643 ; owl:annotatedTarget "Spontaneous closure of eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000646 ; owl:annotatedTarget "Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000646 ; owl:annotatedTarget "Lazy eye" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000646 ; owl:annotatedTarget "Wandering eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000646 ; owl:annotatedTarget "Wandering eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000647 ; owl:annotatedTarget "A congenital anomaly in which a part or the whole of the cornea acquires the characteristics of sclera, resulting in clouding of the cornea." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000647 ; owl:annotatedTarget "Hardening of skin and connective tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000648 ; owl:annotatedTarget "Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy." . [] oboInOwl:hasDbXref , "PMID:19826847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000649 ; owl:annotatedTarget "An anomaly of visually evoked potentials (VEP), which are electrical potentials, initiated by brief visual stimuli, which are recorded from the scalp overlying the visual cortex." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000651 ; owl:annotatedTarget "Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000651 ; owl:annotatedTarget "Double vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000652 ; owl:annotatedTarget "A short discontinuity of the margin of the lower eyelid." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "1,25-DHCC" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000652 ; owl:annotatedTarget "Cleft lower eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000652 ; owl:annotatedTarget "Full thickness defect of the lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000652 ; owl:annotatedTarget "Notched lower eyelid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "1-alpha-25-Dihydroxyvitamin D3" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Decreased density/number of eyelashes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Hypotrichosis of eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Partial absence of eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Scant eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Scanty eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Sparse eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000653 ; owl:annotatedTarget "Thin eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000654 ; owl:annotatedTarget "Descreased amplitude of eletrical response upon electroretinography." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "1alpha,25(OH)2D3" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000656 ; owl:annotatedTarget "An outward turning (eversion) or rotation of the eyelid margin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000656 ; owl:annotatedTarget "Eyelid folded out" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000656 ; owl:annotatedTarget "Eyelid turned out" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000656 ; owl:annotatedTarget "Everted eyelid" . [] oboInOwl:hasDbXref , "PMID:20615230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000657 ; owl:annotatedTarget "Ocular motor apraxia is a deficiency in voluntary, horizontal, lateral, fast eye movements (saccades) with retention of slow pursuit movements. The inability to follow objects visually is often compensated by head movements. There may be decreased smooth pursuit, and cancellation of the vestibulo-ocular reflex." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "1alpha,25-dihydroxycholecalciferol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000658 ; owl:annotatedTarget "Difficulty opening the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000659 ; owl:annotatedTarget "A form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. Peters anomaly is characterized by central, paracentral, or complete corneal opacity." . [] oboInOwl:hasDbXref "PMID:10379021", "PMID:16120862" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000660 ; owl:annotatedTarget "A creamy appearance of the retinal blood vessels that occurs when the concentration of lipids in the blood are extremely increased, with pale pink to milky white retinal vessels and altered pale reflexes from choroidal vasculature." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "1alpha,25-dihydroxyvitamin D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000662 ; owl:annotatedTarget "Inability to see well at night or in poor light." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000662 ; owl:annotatedTarget "Night blindness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000662 ; owl:annotatedTarget "Night-blindness" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000662 ; owl:annotatedTarget "Poor night vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000662 ; owl:annotatedTarget "Difficulties with night vision" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000664 ; owl:annotatedTarget "Meeting of the medial eyebrows in the midline." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000664 ; owl:annotatedTarget "Monobrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000664 ; owl:annotatedTarget "Unibrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000666 ; owl:annotatedTarget "Nystagmus consisting of horizontal to-and-fro eye movements." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000667 ; owl:annotatedTarget "Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease." . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000668 ; owl:annotatedTarget "The absence of five or less teeth from the normal series by a failure to develop." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000668 ; owl:annotatedTarget "Failure of development of between one and six teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000668 ; owl:annotatedTarget "Missing between one and six teeth" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Calcijex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Cariosity of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Dental cavities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Tooth cavities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Tooth decay" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Dental decay" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000670 ; owl:annotatedTarget "Rotting teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "sebacate anion" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Decostriol" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "The absence of all teeth from the normal series by a failure to develop." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Anodontia vera" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Complete agenesis of all teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Failure of development of all teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Complete anodontia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Total anodontia" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "Rocaltrol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Missing all teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000674 ; owl:annotatedTarget "Total absence of all teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Increased size of the maxillary central secondary incisor tooth." . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "calcitriol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Hyperplasia of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Hypertrophy of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Increased size of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Increased size of permanent upper central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Large permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Large permanent upper central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Increased width of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000675 ; owl:annotatedTarget "Increased width of permanent upper central incisor" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "calcitriol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000676 ; owl:annotatedTarget "An abnormality of the Incisor tooth." . [] oboInOwl:hasDbXref "PMID:19125428", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000677 ; owl:annotatedTarget """The absence of six or more teeth from the normal series by a failure to develop.""" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000677 ; owl:annotatedTarget "Failure of development of more than six teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000677 ; owl:annotatedTarget "Missing more than six teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000677 ; owl:annotatedTarget "Number of teeth decreased by more than six" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17823 ; owl:annotatedTarget "calcitriolum" . [] oboInOwl:hasDbXref "PMID:19125428", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Changes in alignment of teeth in the dental arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Inadequate arch length for tooth size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Tooth mass arch size discrepancy" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "LIPID_MAPS_class:LMGL0301" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Tooth size discrepancy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Crowded teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Dental crowding" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Dental overcrowding" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000678 ; owl:annotatedTarget "Overcrowding of teeth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "PMID:2474544" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000679 ; owl:annotatedTarget "Increased volume of dental pulp of permanent molar characterized by a crown body-root ratio equal or larger than 1:1 or an elongated pulp chambers and apical displacement of the bifurcation or trifurcation of the roots." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000679 ; owl:annotatedTarget "Taurodont" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000679 ; owl:annotatedTarget "Large elongated pulp chamber" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "Triglyceride" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Delayed tooth eruption affecting the primary dentition." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Delayed eruption of baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Delayed eruption of milk teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Late eruption of baby teeth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "triglycerides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Late eruption of milk teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000680 ; owl:annotatedTarget "Late eruption of primary teeth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "Triacylglycerol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "An abnormality of the dental enamel." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Abnormal tooth enamel" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Enamel abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Enamel abnormality" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Defective tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Dystrophic tooth enamel" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Malformation of dental enamel" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "sebacate anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "Triglycerid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000682 ; owl:annotatedTarget "Malformation of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "A grey discoloration of the dental enamel." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Gray colored tooth enamel" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "Triglyzerid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Gray tooth shade" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Grayish enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Grey coloured tooth enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Grey tooth shade" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000683 ; owl:annotatedTarget "Greyish enamel" . [] oboInOwl:hasDbXref , "PMID:19125428", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Delayed tooth eruption, which can be defined as tooth eruption more than 2 SD beyond the mean eruption age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Delayed eruption" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Delayed eruption of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Delayed teeth eruption" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Delayed tooth eruption" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "a triacylglycerol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Eruption, delayed" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Late eruption of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000684 ; owl:annotatedTarget "Late tooth eruption" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "triacylglycerols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000685 ; owl:annotatedTarget "Developmental hypoplasia of teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000685 ; owl:annotatedTarget "Decreased size of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000685 ; owl:annotatedTarget "Underdevelopment of teeth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Increased spaces (diastemata) between most of the teeth in the same dental arch." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Generalised dental spacing" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Generalised spacing of teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Generalized dental spacing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Generalized spacing of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Wide-spaced teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Widely spaced teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17855 ; owl:annotatedTarget "triglycerides" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000687 ; owl:annotatedTarget "Widely-spaced teeth" . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Bad bite" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Bilateral crossbite" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Bilateral crossbite malocclusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Incorrect relation between upper and lower dental arches" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Malalignment of upper and lower dental arches" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Malocclusion of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Misalignment of upper and lower dental arches" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Angle class 2 malocclusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000689 ; owl:annotatedTarget "Angle class 3 malocclusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor and maxillary lateral secondary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Failure of development of maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Absence of maxillary lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Absence of upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Missing maxillary lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000690 ; owl:annotatedTarget "Missing upper lateral incisor" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000691 ; owl:annotatedTarget "Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000691 ; owl:annotatedTarget "Hypotrophic tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000691 ; owl:annotatedTarget "Decreased size of tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000691 ; owl:annotatedTarget "Decreased width of tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000691 ; owl:annotatedTarget "Small tooth" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Beilstein:1209725" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormal alignment, positioning, or spacing of the teeth, i.e., misaligned teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormality of position of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormal dental position" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormal teeth spacing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormality of alignment of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Abnormality of teeth spacing" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "sebacates" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "CAS:110-94-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Crooked teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Malaligned teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Malposition of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Malpositioned teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000692 ; owl:annotatedTarget "Misalignment of teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000694 ; owl:annotatedTarget "The diagnosis odontodysplasia requires clinical and radiological exams, in which unusually large pulp chambers and large pulp room chambers with thin enamel and dentin are visible. It may affect either a single tooth or several teeth. The term regional odontodysplasia is used if several teeth are affected. It affects the deciduous and permanent dentitions in the maxilla, the mandible or both, although the maxilla is more frequently involved. A type of dental dysplasia occurring in dentinogenesis imperfecta in which the pulp chambers are enlarged and there is a reduced amount of coronal dentin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000694 ; owl:annotatedTarget "Teeth with dentinal dysplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000694 ; owl:annotatedTarget "Teeth with thin dentin and large pulp chambers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000694 ; owl:annotatedTarget "Teeth with type iii dentinogenesis imperfecta" . [] oboInOwl:hasDbXref "PMID:19125428", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000695 ; owl:annotatedTarget "A tooth present at birth or erupting within the first month of life." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "CAS:110-94-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000695 ; owl:annotatedTarget "Born with teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000695 ; owl:annotatedTarget "Teeth present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000696 ; owl:annotatedTarget "Delayed tooth eruption affecting the secondary dentition." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "CAS:110-94-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000696 ; owl:annotatedTarget "Delayed eruption of adult teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000696 ; owl:annotatedTarget "Delayed eruption of permanent teeth" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "An abnormal conical form of the teeth, that is, a tooth whose sides converge or taper together incisally." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Gmelin:26809" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "Cone shaped tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "Conoid tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "Shark tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "Peg shaped tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000698 ; owl:annotatedTarget "Pointed tooth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Increased space between two adjacent teeth in the same dental arch." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Gaps between teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Dental diastasis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Dental diastema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Diastasis of the teeth" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170046" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Diastema of the teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000699 ; owl:annotatedTarget "Gap between teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Radiolucency (reflecting a reduction in the bony substance) around the apex (the tip of the dental root)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Dark spot around tooth root on x-ray" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Periapical lesion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Bone loss around tooth root" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Periapical cyst" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000700 ; owl:annotatedTarget "Periapical granuloma" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "PMID:24297153" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000703 ; owl:annotatedTarget "Developmental dysplasia of dentin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "PMID:24587932" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000704 ; owl:annotatedTarget "Inflammation of the periodontium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000704 ; owl:annotatedTarget "Gum disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000704 ; owl:annotatedTarget "Pyorrhea" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "PMID:24900967" . [] oboInOwl:hasDbXref , "PMID:18499550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000705 ; owl:annotatedTarget "A developmental dysplasia of the dental enamel." . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000706 ; owl:annotatedTarget "A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000706 ; owl:annotatedTarget "Unerupted dentition" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Reaxys:1209725" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000706 ; owl:annotatedTarget "Failure of eruption of tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000706 ; owl:annotatedTarget "Unerupted tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000707 ; owl:annotatedTarget "An abnormality of the nervous system." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "GLUTARIC ACID" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000707 ; owl:annotatedTarget "Brain and/or spinal cord issue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000707 ; owl:annotatedTarget "Abnormality of the nervous system" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000707 ; owl:annotatedTarget "Neurologic abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000707 ; owl:annotatedTarget "Neurological abnormality" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "sebacic acid anion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Glutaric acid" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral abnormality" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral changes" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral disorders" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral disturbances" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral problems" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral symptoms" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioral/psychiatric abnormalities" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural abnormality" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural changes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "pentanedioic acid" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural disorders" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural disturbances" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural problems" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural symptoms" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Behavioural/Psychiatric abnormality" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Psychiatric disorders" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000708 ; owl:annotatedTarget "Psychiatric disturbances" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "1,3-Propanedicarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000709 ; owl:annotatedTarget "A condition characterized by changes of personality and thought patterns often accompanied by hallucinations and delusional beliefs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000709 ; owl:annotatedTarget "Psychosis" . [] oboInOwl:hasDbXref "PMID:29112858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000710 ; owl:annotatedTarget "Hyperorality is a condition characterized by an excessive preoccupation with oral sensations and behaviors, such as chewing, sucking, biting, swallowing, and excessive mouthing of objects." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000710 ; owl:annotatedTarget "Hyperoralia" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000710 ; owl:annotatedTarget "Hyperorality" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000710 ; owl:annotatedTarget "Mouthing" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "1,5-pentanedioic acid" . [] oboInOwl:hasDbXref "PMID:28332736" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000711 ; owl:annotatedTarget "A state of unease characterized by diffuse motor activity or motion, subject to limited control, nonproductive, or disorganized behavior." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000711 ; owl:annotatedTarget "Fidgetiness" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000711 ; owl:annotatedTarget "Restiveness" . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000712 ; owl:annotatedTarget "Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000712 ; owl:annotatedTarget "Emotional instability" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000712 ; owl:annotatedTarget "Mood changes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000712 ; owl:annotatedTarget "Mood swings" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Glutarsaeure" . [] oboInOwl:hasDbXref "PMID:29630205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000713 ; owl:annotatedTarget "A state of exceeding restlessness and excessive motor activity associated with mental distress or a feeling of inner tension." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17859 ; owl:annotatedTarget "Pentanedioic acid" . [] oboInOwl:hasDbXref , "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000716 ; owl:annotatedTarget "Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000716 ; owl:annotatedTarget "Depression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000717 ; owl:annotatedTarget "Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. Autism begins in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual (DSM-IV)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000717 ; owl:annotatedTarget "Autism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "Aggression" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "Aggressive behavior" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "Aggressive behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "Aggressiveness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000718 ; owl:annotatedTarget "physical aggression" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000719 ; owl:annotatedTarget "Inappropriate behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000719 ; owl:annotatedTarget "Inappropriate behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000721 ; owl:annotatedTarget "Lack of spontaneous play" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "CAS:7647-01-0" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "OCD" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive compulsive behavior" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive compulsive behaviour" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive compulsive disorder" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive-compulsive behavior" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive-compulsive behaviour" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000722 ; owl:annotatedTarget "Obsessive-compulsive disorder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132954 ; owl:annotatedTarget "sebacic acid anions" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "CAS:7647-01-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000723 ; owl:annotatedTarget "Behavior characterized by an abnormal limitation to few interests and activities." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000723 ; owl:annotatedTarget "Restricted behaviour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000723 ; owl:annotatedTarget "Restrictive behavior, interests, and activities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000725 ; owl:annotatedTarget "Psychotic episodes" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "CAS:7647-01-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000726 ; owl:annotatedTarget "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000726 ; owl:annotatedTarget "Dementia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000726 ; owl:annotatedTarget "Dementia, progressive" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000726 ; owl:annotatedTarget "Progressive dementia" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Drug_Central:4568" . [] oboInOwl:hasDbXref , "PMID:28879490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "ASD" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Autistic behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Autism spectrum disorder" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Autism spectrum disorders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Autistic behaviors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000729 ; owl:annotatedTarget "Autistic behaviours" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Gmelin:322" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Motor stereotypy" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Repetitive behaviour Stereotypic behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Repetitive behaviour Stereotypic behaviour" . [] oboInOwl:hasDbXref , , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Repetitive movements" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "PMID:15823700" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotyped" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotyped behavior" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotyped behaviors" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotyped behaviour" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotyped behaviours" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypic behaviour" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypic behaviours" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypical motor behavior" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypical motor behaviors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypical motor behaviour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "PMID:17492841" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stereotypical motor behaviours" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "Stimming" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "repetitive behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000733 ; owl:annotatedTarget "repetitive behaviour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "PMID:22804993" . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000734 ; owl:annotatedTarget "A lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000735 ; owl:annotatedTarget "Difficulty in social interactions related to an impairment of characteristics such as eye contact, smiling, appropriate facial expressions, and body postures and characterized by difficulty in forming peer relationships and forming friendships." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Reaxys:1098214" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000735 ; owl:annotatedTarget "Impaired social interaction" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000735 ; owl:annotatedTarget "Impaired social interactions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000735 ; owl:annotatedTarget "Poor social interactions" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Hydrogen chloride" . [] oboInOwl:hasDbXref "PMID:26386541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000736 ; owl:annotatedTarget "Reduced attention span characterized by distractibility and impulsivity." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000736 ; owl:annotatedTarget "Easily distracted" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000736 ; owl:annotatedTarget "Poor attention span" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000736 ; owl:annotatedTarget "Problem paying attention" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000736 ; owl:annotatedTarget "Short attention span" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "chlorane" . [] oboInOwl:hasDbXref "PMID:27343883" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000737 ; owl:annotatedTarget "A proneness to anger, i.e., a condition of being easily bothered or annoyed." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000737 ; owl:annotatedTarget "Irritability" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000737 ; owl:annotatedTarget "Irritable" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "chloridohydrogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000738 ; owl:annotatedTarget "Perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000738 ; owl:annotatedTarget "Hallucination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000738 ; owl:annotatedTarget "Hallucinations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000738 ; owl:annotatedTarget "Sensory hallucination" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "hydrogen chloride" . [] oboInOwl:hasDbXref , "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000739 ; owl:annotatedTarget "Intense feelings of nervousness, tenseness, or panic, often in reaction to interpersonal stresses; worry about the negative effects of past unpleasant experiences and future negative possibilities; feeling fearful, apprehensive, or threatened by uncertainty; fears of falling apart or losing control." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000739 ; owl:annotatedTarget "Anxiety" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000739 ; owl:annotatedTarget "Excessive, persistent worry and fear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000739 ; owl:annotatedTarget "Anxiety disease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Chlorwasserstoff" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "HCl" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000741 ; owl:annotatedTarget "Lack of feeling, emotion, interest" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000742 ; owl:annotatedTarget "Deliberate self-harm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000742 ; owl:annotatedTarget "Self mutilation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000742 ; owl:annotatedTarget "Self-mutilation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000743 ; owl:annotatedTarget "Primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Hydrochloride" . [] oboInOwl:hasDbXref "PMID:21461367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000744 ; owl:annotatedTarget "The feeling of frustration can be defined as an emotional reaction that occurs if a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration characterized by crying or temper tantrums (in children) or aggressive or other undesirable behaviors." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Hydrogenchlorid" . [] oboInOwl:hasDbXref , "PMID:16030444" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "Diminished motivation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "Lack of initiative" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "Lack of motivation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "Lacking in initiative" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000745 ; owl:annotatedTarget "Lacks initiative" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "Wasserstoffchlorid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000746 ; owl:annotatedTarget "A false belief that is held despite evidence to the contrary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000746 ; owl:annotatedTarget "Delusions" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "[HCl]" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000748 ; owl:annotatedTarget "Inappropriate laughter" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "A degree of language development that is significantly below the norm for a child of a specified age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Deficiency of speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Delayed language development" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Delayed speech" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "chlorure d'hydrogene" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Delayed speech acquisition" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Delayed speech and language development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Delayed speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Impaired speech and language development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Impaired speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Language delay" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Language delayed" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Language development deficit" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Late-onset speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Poor language development" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "cloruro de hidrogeno" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Speech and language delay" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Speech and language difficulties" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Speech delay" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Poor speech acquisition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Poor speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000750 ; owl:annotatedTarget "Speech difficulties" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "2-methylbutanedioic acid anion" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17883 ; owl:annotatedTarget "hydrochloric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000751 ; owl:annotatedTarget "An abnormal shift in patterns of thinking, acting, or feeling." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000751 ; owl:annotatedTarget "Personality change" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000751 ; owl:annotatedTarget "Personality changes" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17891 ; owl:annotatedTarget "Donor" . [] oboInOwl:hasDbXref "PMID:26386541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000752 ; owl:annotatedTarget "Hyperactivity is a state of constantly being unusually or abnormally active, including in situations in which it is not appropriate." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000752 ; owl:annotatedTarget "Hyperactive behavior" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000752 ; owl:annotatedTarget "Hyperactive behaviour" . [] oboInOwl:hasDbXref , , , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000752 ; owl:annotatedTarget "More active than typical" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000752 ; owl:annotatedTarget "hyperkinetic disorder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17891 ; owl:annotatedTarget "Donator" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000756 ; owl:annotatedTarget "A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000756 ; owl:annotatedTarget "Fear of open spaces" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000757 ; owl:annotatedTarget "Lack of insight" . [] oboInOwl:hasDbXref "PMID:34981308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000758 ; owl:annotatedTarget "Abnormalities in eye contact, communicative facial expressions, gesture use, or use of other's body to communicate. These convey a shared meaning within a culture that replace or supplement verbal communication." . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000758 ; owl:annotatedTarget "Impaired use of nonverbal behaviors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17891 ; owl:annotatedTarget "donneur" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000758 ; owl:annotatedTarget "Impaired use of nonverbal behaviours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000759 ; owl:annotatedTarget "A structural abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000759 ; owl:annotatedTarget "Abnormal peripheral nervous system structure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000762 ; owl:annotatedTarget "A reduction in the speed at which electrical signals propagate along the axon of a neuron." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000763 ; owl:annotatedTarget "Peripheral neuropathy affecting the sensory nerves." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000763 ; owl:annotatedTarget "Damage to nerves that sense feeling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000764 ; owl:annotatedTarget "Progressive deterioration of peripheral axons." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17893 ; owl:annotatedTarget "(2R)-2-hydroxy monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000765 ; owl:annotatedTarget "Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000765 ; owl:annotatedTarget "Abnormality of the chest" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17893 ; owl:annotatedTarget "(2R)-Hydroxy-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000766 ; owl:annotatedTarget "An anomaly of the sternum, also known as the breastbone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000766 ; owl:annotatedTarget "Abnormality of the sternum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000766 ; owl:annotatedTarget "Sternal anomalies" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17893 ; owl:annotatedTarget "(R)-2-Hydroxyacid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000767 ; owl:annotatedTarget "A defect of the chest wall characterized by a depression of the sternum, giving the chest (\"pectus\") a caved-in (\"excavatum\") appearance." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000767 ; owl:annotatedTarget "Funnel chest" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17893 ; owl:annotatedTarget "(R)-2-Hydroxycarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000768 ; owl:annotatedTarget "A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/pectus_carinatum" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000768 ; owl:annotatedTarget "Pigeon chest" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "2-methylbutanedioic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000769 ; owl:annotatedTarget "An abnormality of the breast." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000769 ; owl:annotatedTarget "Abnormality of the breast" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000771 ; owl:annotatedTarget "Abnormal development of large mammary glands in males resulting in breast enlargement." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000771 ; owl:annotatedTarget "Enlarged male breast" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000772 ; owl:annotatedTarget "An anomaly of the rib." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000772 ; owl:annotatedTarget "Abnormality of the ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000772 ; owl:annotatedTarget "Rib abnormalities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000773 ; owl:annotatedTarget "Reduced rib length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000773 ; owl:annotatedTarget "Short ribs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000774 ; owl:annotatedTarget "Reduced width of the chest from side to side, associated with a reduced distance from the sternal notch to the tip of the shoulder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000774 ; owl:annotatedTarget "Low chest circumference" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000774 ; owl:annotatedTarget "Narrow chest" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000774 ; owl:annotatedTarget "Narrow shoulders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000775 ; owl:annotatedTarget "Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000775 ; owl:annotatedTarget "Abnormality of the diaphragm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000775 ; owl:annotatedTarget "Diaphragm issues" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000775 ; owl:annotatedTarget "Diaphragmatic defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000776 ; owl:annotatedTarget "The presence of a hernia of the diaphragm present at birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000777 ; owl:annotatedTarget "Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000777 ; owl:annotatedTarget "Abnormality of the thymus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000778 ; owl:annotatedTarget "Underdevelopment of the thymus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000778 ; owl:annotatedTarget "Small thymus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000782 ; owl:annotatedTarget "Any abnormality of the scapula, also known as the shoulder blade." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000782 ; owl:annotatedTarget "Abnormality of the shoulder blade" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000787 ; owl:annotatedTarget "The presence of calculi (stones) in the kidneys." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000787 ; owl:annotatedTarget "Kidney stones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "methylsuccinate anion" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Beilstein:1721899" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000789 ; owl:annotatedTarget "Infertility" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Beilstein:4656395" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000790 ; owl:annotatedTarget "The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000790 ; owl:annotatedTarget "High urine occult blood" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "CAS:50-70-4" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000790 ; owl:annotatedTarget "Blood in urine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000791 ; owl:annotatedTarget "The presence of uric acid-containing calculi (stones) in the kidneys." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000791 ; owl:annotatedTarget "Uric acid stones" . [] oboInOwl:hasDbXref "PMID:19908070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000793 ; owl:annotatedTarget "A type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000793 ; owl:annotatedTarget "MPGN" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000794 ; owl:annotatedTarget "The presence of immunoglobulin A deposits in the glomerulus." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "CAS:50-70-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000795 ; owl:annotatedTarget "An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000795 ; owl:annotatedTarget "Urethra issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000796 ; owl:annotatedTarget "Obstruction of the flow of urine through the urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000798 ; owl:annotatedTarget "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000798 ; owl:annotatedTarget "Low sperm count" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "CAS:50-70-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000799 ; owl:annotatedTarget "Abnormal fat accumulation in the kidneys." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Drug_Central:2462" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000799 ; owl:annotatedTarget "Fatty kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000802 ; owl:annotatedTarget "Inability to develop or maintain an erection of the penis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000802 ; owl:annotatedTarget "Difficulty getting a full erection" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Gmelin:83162" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000802 ; owl:annotatedTarget "Difficulty getting an erection" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000803 ; owl:annotatedTarget "Cysts of the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000804 ; owl:annotatedTarget "The presence of xanthine-containing calculi (stones) in the kidneys." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000805 ; owl:annotatedTarget "Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000808 ; owl:annotatedTarget "A severe form of hypospadias in which the urethral opening is located at the junction of the penis and scrotum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000809 ; owl:annotatedTarget "Congenital absence of the normal opening of a structure of the urinary tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "methylsuccinates" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:19443021" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000811 ; owl:annotatedTarget "Abnormal external genitalia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000812 ; owl:annotatedTarget "An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000812 ; owl:annotatedTarget "Abnormal internal genitalia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:19695255" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000813 ; owl:annotatedTarget "The presence of a bicornuate uterus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000813 ; owl:annotatedTarget "Heart shaped uterus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000813 ; owl:annotatedTarget "Heart-shaped uterus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000815 ; owl:annotatedTarget "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000816 ; owl:annotatedTarget "An abnormality of the tricarboxylic acid cycle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000816 ; owl:annotatedTarget "Abnormality of citric acid cycle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:22878210" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000817 ; owl:annotatedTarget "Poor eye contact" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:23683321" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000818 ; owl:annotatedTarget "An abnormality of the endocrine system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000819 ; owl:annotatedTarget "A group of abnormalities characterized by hyperglycemia and glucose intolerance." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000820 ; owl:annotatedTarget "An abnormality of the thyroid gland." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000820 ; owl:annotatedTarget "Abnormality of the thyroid gland" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000820 ; owl:annotatedTarget "Thyroid abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000820 ; owl:annotatedTarget "Thyroid disease" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000821 ; owl:annotatedTarget "Deficiency of thyroid hormone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000821 ; owl:annotatedTarget "Underactive thyroid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:25568069" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "PMID:31537530" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000822 ; owl:annotatedTarget "The presence of chronic increased pressure in the systemic arterial system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000822 ; owl:annotatedTarget "High blood pressure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000823 ; owl:annotatedTarget "Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Reaxys:1721899" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000823 ; owl:annotatedTarget "Delayed pubertal development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000823 ; owl:annotatedTarget "Delayed pubertal growth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000823 ; owl:annotatedTarget "Delayed puberty" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000823 ; owl:annotatedTarget "Pubertal delay" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "methylsuccinic acid anion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-Glucitol" . [] oboInOwl:hasDbXref , "PMID:25914878" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000824 ; owl:annotatedTarget "Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000824 ; owl:annotatedTarget "Growth hormone deficiency" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-glucitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000825 ; owl:annotatedTarget "An increased concentration of insulin combined with a decreased concentration of glucose in the blood." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "(-)-sorbitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000826 ; owl:annotatedTarget "The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000826 ; owl:annotatedTarget "Early onset of puberty" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000826 ; owl:annotatedTarget "Early puberty" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000828 ; owl:annotatedTarget "An abnormality of the parathyroid gland." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-(-)-sorbitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000829 ; owl:annotatedTarget "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000829 ; owl:annotatedTarget "Decreased parathyroid hormone secretion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000830 ; owl:annotatedTarget "A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone." . [] oboInOwl:hasDbXref , "PMID:7706500" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000831 ; owl:annotatedTarget "A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as well as in fasting and postprandial serum insulin levels." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000831 ; owl:annotatedTarget "Insulin resistant diabetes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000831 ; owl:annotatedTarget "Insulin-resistant diabetes" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-SORBITOL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000832 ; owl:annotatedTarget "A type of hypothyroidism that results from a defect in the thyroid gland." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-Sorbit" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000834 ; owl:annotatedTarget "Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000834 ; owl:annotatedTarget "Adrenal abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000834 ; owl:annotatedTarget "Adrenal gland disease" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-Sorbitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000835 ; owl:annotatedTarget "Developmental hypoplasia of the adrenal glands." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000835 ; owl:annotatedTarget "Small adrenal glands" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "D-sorbitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000836 ; owl:annotatedTarget "An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." . [] oboInOwl:hasDbXref , "http://www.mayoclinic.org/diseases-conditions/hyperthyroidism/basics/definition/con-20020986" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000836 ; owl:annotatedTarget "Overactive thyroid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "E 420" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000837 ; owl:annotatedTarget "Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000837 ; owl:annotatedTarget "Elevated gonadotropins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000837 ; owl:annotatedTarget "Elevated serum gonadotropins" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132961 ; owl:annotatedTarget "methylsuccinic acid anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "E-420" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000837 ; owl:annotatedTarget "Gonadotropin excess" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000837 ; owl:annotatedTarget "Increased circulating gonadotropin level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000839 ; owl:annotatedTarget "A type of reduced stature with normal proportions related to dysfunction of the pituitary gland related to either an isolated defect in the secretion of growth hormone or to panhypopituitarism, i.e., a deficit of all the anterior pituitary hormones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000840 ; owl:annotatedTarget "Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "E420" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000841 ; owl:annotatedTarget "An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000841 ; owl:annotatedTarget "Increased plasma renin activity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "G-ol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000842 ; owl:annotatedTarget "An increased concentration of insulin in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "Glc-ol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000843 ; owl:annotatedTarget "Excessive production of parathyroid hormone (PTH) by the parathyroid glands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000843 ; owl:annotatedTarget "Elevated blood parathyroid hormone level" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17924 ; owl:annotatedTarget "L-Gulitol" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000845 ; owl:annotatedTarget "Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000845 ; owl:annotatedTarget "Growth hormone excess" . [] oboInOwl:hasDbXref , "PMID:11443143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000846 ; owl:annotatedTarget "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000847 ; owl:annotatedTarget "An abnormality of the renin-angiotensin system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000848 ; owl:annotatedTarget "An increased level of renin in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000848 ; owl:annotatedTarget "Elevated blood renin level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000851 ; owl:annotatedTarget "A type of hypothyroidism with congenital onset." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000851 ; owl:annotatedTarget "Underactive thyroid gland from birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000852 ; owl:annotatedTarget "A condition characterized by resistance to the action of parathyroid hormone, in which there is hypocalcemia, hyperphosphatemia, and (appropriately) high levels of parathyroid hormone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000853 ; owl:annotatedTarget "An enlargement of the thyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000853 ; owl:annotatedTarget "Enlarged thyroid gland in neck" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000853 ; owl:annotatedTarget "Goitre" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000853 ; owl:annotatedTarget "Thyroid goitre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000854 ; owl:annotatedTarget "The presence of a adenoma of the thyroid gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132966 ; owl:annotatedTarget "N-benzoylglycinates" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Beilstein:4270041" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000855 ; owl:annotatedTarget "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000855 ; owl:annotatedTarget "Body fails to respond to insulin" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "CAS:19356-17-3" . [] oboInOwl:hasDbXref "PMID:29323693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000858 ; owl:annotatedTarget "Abnormally high variation in the amount of time between periods." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000858 ; owl:annotatedTarget "Menstrual irregularity" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "CAS:19356-17-3" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000859 ; owl:annotatedTarget "Overproduction of the mineralocorticoid aldosterone by the adrenal cortex." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Drug_Central:464" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000859 ; owl:annotatedTarget "Elevated plasma aldosterone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000859 ; owl:annotatedTarget "Increased aldosterone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000859 ; owl:annotatedTarget "Increased aldosterone production" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST03020246" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000860 ; owl:annotatedTarget "Developmental hypoplasia of the parathyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000860 ; owl:annotatedTarget "Small parathyroid glands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000860 ; owl:annotatedTarget "Underdeveloped parathyroid glands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000863 ; owl:annotatedTarget "A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:16549446" . _:genid37751 oboInOwl:hasDbXref ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000864 ; owl:annotatedTarget "Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0003008 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0002196 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0000468 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000866 ; owl:annotatedTarget "Euthyroid multinodular goitre" . [] oboInOwl:hasDbXref , "PMID:19836494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000867 ; owl:annotatedTarget "Secondary hyperparathyroidism refers to the production of higher than normal levels of parathyroid hormone in the presence of hypocalcemia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000868 ; owl:annotatedTarget "Decreased fertility in females" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000868 ; owl:annotatedTarget "Reduced fertility in females" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000869 ; owl:annotatedTarget "Previous menstrual periods stop" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:18689406" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000870 ; owl:annotatedTarget "The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:22487892" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0000871 ; owl:annotatedTarget _:genid37751 . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:22536761" . [] oboInOwl:hasDbXref , "PMID:12466332" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000871 ; owl:annotatedTarget "A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000872 ; owl:annotatedTarget "A chronic, autoimmune type of thyroiditis associated with hypothyroidism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000873 ; owl:annotatedTarget "A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000875 ; owl:annotatedTarget "Intermittent high blood pressure" . [] oboInOwl:hasDbXref , "PMID:22594864" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000876 ; owl:annotatedTarget "Infrequent menses (less than 6 per year or more than 35 days between cycles)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000876 ; owl:annotatedTarget "Light or infrequent menstrual periods" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000877 ; owl:annotatedTarget "Insulin-resistant diabetes mellitus at puberty" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000878 ; owl:annotatedTarget "Presence of only 11 pairs of ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000878 ; owl:annotatedTarget "11 pairs of ribs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:23090338" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000879 ; owl:annotatedTarget "Decreased inferosuperior length of the sternum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000879 ; owl:annotatedTarget "Short sternum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132966 ; owl:annotatedTarget "N-benzoylglycine anions" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:23566108" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000882 ; owl:annotatedTarget "Underdeveloped scapula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000882 ; owl:annotatedTarget "Small shoulder blade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "PMID:9080330" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000883 ; owl:annotatedTarget "Ribs with a reduced diameter." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000883 ; owl:annotatedTarget "Slender ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000883 ; owl:annotatedTarget "Thin ribs" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Reaxys:4270041" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000884 ; owl:annotatedTarget "Prominent sternum" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000885 ; owl:annotatedTarget "Increased width of ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000885 ; owl:annotatedTarget "Broad ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000885 ; owl:annotatedTarget "Wide ribs" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Calcidiol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000886 ; owl:annotatedTarget "Malformation of the rib cage." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000886 ; owl:annotatedTarget "Deformed rib cage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000887 ; owl:annotatedTarget "Wide, concave rib end." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000887 ; owl:annotatedTarget "Cupped ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000887 ; owl:annotatedTarget "Rib cupping" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000887 ; owl:annotatedTarget "Rib flaring" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "calcidiol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000888 ; owl:annotatedTarget "A horizontal (flat) conformation of the ribs, the long curved bones that form the rib cage and normally progressively oblique (slanted) from ribs 1 through 9, then less slanted through rib 12." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000888 ; owl:annotatedTarget "Horizontal ribs" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000889 ; owl:annotatedTarget "Any abnormality of the clavicles (collar bones)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000889 ; owl:annotatedTarget "Abnormal collarbone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000890 ; owl:annotatedTarget "Increased length of the clavicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000890 ; owl:annotatedTarget "Long collarbone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000892 ; owl:annotatedTarget "A bifid rib refers to cleavage of the sternal end of a rib, usually unilateral. Bifid ribs are usually asymptomatic, and are often discovered incidentally by chest x-ray." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000892 ; owl:annotatedTarget "Cleft ribs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000892 ; owl:annotatedTarget "Split ribs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "25(OH)D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000893 ; owl:annotatedTarget "Abnormal outward curving (protuberance) of the junction of ribs and costal cartilage." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "25-Hydroxyvitamin D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000894 ; owl:annotatedTarget "Reduced length of the clavicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000894 ; owl:annotatedTarget "Short collarbone" . [] oboInOwl:hasDbXref , "PMID:7322653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000895 ; owl:annotatedTarget "An excessive upward convexity of the lateral clavicle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000895 ; owl:annotatedTarget "Hook-shaped collarbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000896 ; owl:annotatedTarget "Multiple circumscribed bony excrescences located in the ribs." . [] oboInOwl:hasDbXref , "PMID:26745253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000897 ; owl:annotatedTarget "A row of beadlike prominences at the junction of a rib and its cartilage (i.e., enlarged costochondral joints), resembling a rosary." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "25-hydroxycholecalciferol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000900 ; owl:annotatedTarget "Increased thickness (diameter) of ribs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "25-hydroxyvitamin D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000902 ; owl:annotatedTarget "Complete or partial merging of adjacent ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000902 ; owl:annotatedTarget "Fused ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000902 ; owl:annotatedTarget "Rib fusion" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000904 ; owl:annotatedTarget "The presence of wide, concave anterior rib ends." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000904 ; owl:annotatedTarget "Flaring of rib cage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000905 ; owl:annotatedTarget "Progressive bone resorption in the distal part of the clavicle." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Calcifediol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000907 ; owl:annotatedTarget "Wide, concave anterior rib end." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Calcifediol anhydrous" . [] oboInOwl:hasDbXref , "PMID:15163819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000911 ; owl:annotatedTarget "Abnormally flat configuration of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000912 ; owl:annotatedTarget "A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other)." . [] a owl:Axiom ; rdfs:label "Congenital elevation of scapula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000912 ; owl:annotatedTarget "MEDDRA:10010455" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/sprengel%27s_deformity" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000912 ; owl:annotatedTarget "High scapula" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000912 ; owl:annotatedTarget "High shoulder blade" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000913 ; owl:annotatedTarget "Complete or partial merging of the posterior part of adjacent ribs." . [] oboInOwl:hasDbXref , "PMID:22368597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000914 ; owl:annotatedTarget "A broad chest." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000914 ; owl:annotatedTarget "Shield chest" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000914 ; owl:annotatedTarget "Broad chest" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "Rayaldee" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000915 ; owl:annotatedTarget "Pectus excavatum (defect of the chest wall characterized by depression of the sternum) affecting primarily the inferior region of the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000916 ; owl:annotatedTarget "Increased width (cross-sectional diameter) of the clavicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000916 ; owl:annotatedTarget "Broad collarbone" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "calcifediol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000917 ; owl:annotatedTarget "Pectus carinatum affecting primarily the superior part of the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000918 ; owl:annotatedTarget "The presence of multiple exostoses on the scapula. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000918 ; owl:annotatedTarget "Shoulder bone exostoes" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "calcifediol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000919 ; owl:annotatedTarget "Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000920 ; owl:annotatedTarget "Abnormally increased size of the costochondral junctions, which are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17933 ; owl:annotatedTarget "calcifediolum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000921 ; owl:annotatedTarget "A developmental anomaly with absence of one or more ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000921 ; owl:annotatedTarget "Absent ribs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000921 ; owl:annotatedTarget "Decreased rib number" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000921 ; owl:annotatedTarget "Missing ribs" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_132970 ; owl:annotatedTarget "4-carboxy-2-oxobutan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000922 ; owl:annotatedTarget "Wide, concave posterior rib end." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000923 ; owl:annotatedTarget "The presence of a row of multiple rounded expansions (beadlike prominences) at the junction of a rib and its cartilage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000924 ; owl:annotatedTarget "An abnormality of the skeletal system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000924 ; owl:annotatedTarget "Abnormality of the skeletal system" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000924 ; owl:annotatedTarget "Skeletal abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000924 ; owl:annotatedTarget "Skeletal anomalies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Any abnormality of the vertebral column." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Abnormal spine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Abnormal vertebral column" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Abnormality of the spine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Abnormality of the vertebral column" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000925 ; owl:annotatedTarget "Abnormality of the backbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000926 ; owl:annotatedTarget "A flattened vertebral body shape with reduced distance between the vertebral endplates." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000926 ; owl:annotatedTarget "Flattened vertebrae" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "Beilstein:3601060" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000927 ; owl:annotatedTarget "The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000927 ; owl:annotatedTarget "Abnormality of skeletal maturation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "CAS:461-55-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000929 ; owl:annotatedTarget "An abnormality of the skull, the bony framework of the head which is comprised of the neurocranium (with eight cranial bones) and the viscerocranium (facial skeleton) that comprises fourteen facial bones with the mandible as its largest bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000929 ; owl:annotatedTarget "Abnormality of the skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000929 ; owl:annotatedTarget "Abnormality of the skull bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "Gmelin:324289" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000930 ; owl:annotatedTarget "Elevated imprint of occipital bone over the transverse sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000930 ; owl:annotatedTarget "Elevated imprint of posterior skull bones over the transverse sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000930 ; owl:annotatedTarget "Thinning and bulging of occipital bone over the transverse sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000930 ; owl:annotatedTarget "Thinning and bulging of posterior skull bones over the transverse sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000931 ; owl:annotatedTarget "Thinning and bulging of posterior skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0000931 ; owl:annotatedTarget "Thinning and bulging of occipital bone of skull" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref , "PMID:25970099", "PMID:28295149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000932 ; owl:annotatedTarget "An abnormality of the fossa cranii posterior (the posterior fossa), which is made up primarily of the occipital bone and which surrounds to the foramen magnum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000934 ; owl:annotatedTarget "Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) ." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000934 ; owl:annotatedTarget "Calcium deposits in joints" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "PMID:7496326" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000935 ; owl:annotatedTarget "Abnormal thickening of the cortex of long bones." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "Reaxys:3601060" . [] oboInOwl:hasDbXref , "PMID:21234807" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000938 ; owl:annotatedTarget "Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000938 ; owl:annotatedTarget "Generalised osteopenia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000938 ; owl:annotatedTarget "Osteopaenia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132970 ; owl:annotatedTarget "5-aminolevulinic acid cation" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "UM-BBD_compID:c0035" . [] oboInOwl:hasDbXref , "PMID:28293453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000939 ; owl:annotatedTarget "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000940 ; owl:annotatedTarget "An abnormality of the structure or form of the diaphysis, i.e., of the main or mid-section (shaft) of a long bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000940 ; owl:annotatedTarget "Abnormal shape of shaft of long bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000940 ; owl:annotatedTarget "Abnormality of shaft of long bone of the limbs" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butyrate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000941 ; owl:annotatedTarget "Short shaft of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "1-butanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000944 ; owl:annotatedTarget "An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000944 ; owl:annotatedTarget "Abnormality of the wide portion of a long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "1-butyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000946 ; owl:annotatedTarget "Underdevelopment of the ilium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000946 ; owl:annotatedTarget "Small wings of the pelvic girdle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000947 ; owl:annotatedTarget "An abnormal appearance of the long bones with resemblance to a dumbbell, a short bar with a weight at each end. That is, the long bone is shortened and displays flaring (widening) of the metaphyses." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "1-propanecarboxylate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000947 ; owl:annotatedTarget "Dumbbell-shaped long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000951 ; owl:annotatedTarget "An abnormality of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000951 ; owl:annotatedTarget "Abnormality of the skin" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "CH3-[CH2]2-COO(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000951 ; owl:annotatedTarget "Dermatopathy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000951 ; owl:annotatedTarget "Dermopathy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000952 ; owl:annotatedTarget "Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000952 ; owl:annotatedTarget "Icterus" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000952 ; owl:annotatedTarget "Jaundice" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000952 ; owl:annotatedTarget "Yellow skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000952 ; owl:annotatedTarget "Yellowing of the skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butanate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000953 ; owl:annotatedTarget "A darkening of the skin related to an increase in melanin production and deposition." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000953 ; owl:annotatedTarget "Hyperpigmented lesion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butanoate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000953 ; owl:annotatedTarget "Patchy darkened skin" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000954 ; owl:annotatedTarget "The distal and proximal transverse palmar creases are merged into a single transverse palmar crease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000954 ; owl:annotatedTarget "Simian line" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butanoate" . [] oboInOwl:hasDbXref , "PMID:19061584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000956 ; owl:annotatedTarget "A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000956 ; owl:annotatedTarget "Darkened and thickened skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000956 ; owl:annotatedTarget "Keratosis nigricans" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000957 ; owl:annotatedTarget "Cafe-au-lait spots are hyperpigmented lesions that can vary in color from light brown to dark brown with smooth borders and having a size of 1.5 cm or more in adults and 0.5 cm or more in children." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000957 ; owl:annotatedTarget "Birthmark" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000957 ; owl:annotatedTarget "Flat light-brown mark on skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000957 ; owl:annotatedTarget "Cafe-au-lait macule" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000957 ; owl:annotatedTarget "Cafe-au-lait spots" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_132970 ; owl:annotatedTarget "5-aminolevulinic acid(1+)" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "butanoic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000958 ; owl:annotatedTarget "Skin characterized by the lack of natural or normal moisture." . [] a owl:Axiom ; rdfs:label "Xerosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000958 ; owl:annotatedTarget "MEDDRA:10048222" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000958 ; owl:annotatedTarget "Dry skin" . [] oboInOwl:hasDbXref , "PMID:28245993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000960 ; owl:annotatedTarget "A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the intergluteal cleft." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/sacral_dimple" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000960 ; owl:annotatedTarget "Spinal dimple" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "n-butanoate" . [] oboInOwl:hasDbXref "PMID:25658213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000961 ; owl:annotatedTarget "Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000961 ; owl:annotatedTarget "Blue discoloration of the skin" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "n-butyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000962 ; owl:annotatedTarget "Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum." . [] a owl:Axiom ; rdfs:label "Hyperkeratosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000962 ; owl:annotatedTarget "MEDDRA:10020649" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "propanecarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000963 ; owl:annotatedTarget "Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000963 ; owl:annotatedTarget "Thin skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17968 ; owl:annotatedTarget "propylformate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000964 ; owl:annotatedTarget "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000964 ; owl:annotatedTarget "Eczema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000965 ; owl:annotatedTarget "A reticular discoloration of the skin with cyanotic (reddish-blue appearing) areas surrounding pale central areas due to dilation of capillary blood vessels and stagnation of blood within the vessels. Cutis marmorata generally occurs on the legs, arms and trunk and is often more severe in cold weather." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "Abnormally diminished capacity to sweat." . [] a owl:Axiom ; rdfs:label "Hypohidrosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "MEDDRA:10021013" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "Decreased ability to sweat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "Decreased sweating" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "Inadequate sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000966 ; owl:annotatedTarget "Sweating, decreased" . [] oboInOwl:hasDbXref , "PMID:29493956" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000967 ; owl:annotatedTarget "Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae." . [] a owl:Axiom ; rdfs:label "Petechiae" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000967 ; owl:annotatedTarget "MEDDRA:10034754" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000968 ; owl:annotatedTarget "Ectodermal dysplasia is a group of conditions in which there is abnormal development of the skin, hair, nails, teeth, or sweat glands." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000969 ; owl:annotatedTarget "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000969 ; owl:annotatedTarget "Dropsy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000969 ; owl:annotatedTarget "Fluid retention" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000969 ; owl:annotatedTarget "Water retention" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000970 ; owl:annotatedTarget "Inability to sweat." . [] a owl:Axiom ; rdfs:label "Anhidrosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000970 ; owl:annotatedTarget "MEDDRA:10002512" . [] oboInOwl:hasDbXref , "http://www.medicalnewstoday.com/articles/266427.php" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000970 ; owl:annotatedTarget "Lack of sweating" . [] oboInOwl:hasDbXref , "http://www.medicalnewstoday.com/articles/266427.php" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000970 ; owl:annotatedTarget "Sudomotor dysfunction" . [] oboInOwl:hasDbXref , "http://www.medicalnewstoday.com/articles/266427.php" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000970 ; owl:annotatedTarget "Sweating dysfunction" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Beilstein:3587171" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000971 ; owl:annotatedTarget "Any structural abnormality of the sweat gland." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000971 ; owl:annotatedTarget "Abnormality of the sweat gland" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000971 ; owl:annotatedTarget "Abnormalities of sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000971 ; owl:annotatedTarget "Sweat gland disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000972 ; owl:annotatedTarget "Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000972 ; owl:annotatedTarget "Thickening of the outer layer of the skin of the palms and soles" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133251 ; owl:annotatedTarget "3-hydroxydicarboxylic acid dianion(2-)" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "CAS:16887-00-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Wrinkled, redundant, inelastic and sagging skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Hanging skin" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/cutis_laxa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Chalazoderma" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/cutis_laxa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Dermatochalasia" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/cutis_laxa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Dermatomegaly" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Generalised elastolysis" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/cutis_laxa" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Generalized elastolysis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "CAS:16887-00-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Inelastic skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000973 ; owl:annotatedTarget "Loose and inelastic skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000974 ; owl:annotatedTarget "A condition in which the skin can be stretched beyond normal, and then returns to its initial position." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "CAS:16887-00-6" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000974 ; owl:annotatedTarget "Hyperelastic skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000974 ; owl:annotatedTarget "Skin hyperelasticity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000974 ; owl:annotatedTarget "Stretchable skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather." . [] a owl:Axiom ; rdfs:label "Hyperhidrosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "MEDDRA:10020642" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Excessive sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Increased sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Profuse sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Sweating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Sweating profusely" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Gmelin:14910" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000975 ; owl:annotatedTarget "Sweating, increased" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000977 ; owl:annotatedTarget "Subjective impression of increased softness upon palpation of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000977 ; owl:annotatedTarget "Soft skin" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "UM-BBD_compID:c0884" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000977 ; owl:annotatedTarget "Velvety skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000977 ; owl:annotatedTarget "Velvety skin texture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000978 ; owl:annotatedTarget "An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Chloride" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000978 ; owl:annotatedTarget "Bruise easily" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000978 ; owl:annotatedTarget "Bruising susceptibility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000978 ; owl:annotatedTarget "Easy bruisability" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000978 ; owl:annotatedTarget "Easy bruising" . [] oboInOwl:hasDbXref , "PMID:11515831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000979 ; owl:annotatedTarget "Purpura (from Latin: purpura, meaning \"purple\") is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000979 ; owl:annotatedTarget "Blood spots" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000979 ; owl:annotatedTarget "Red or purple spots on the skin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "chloride" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000980 ; owl:annotatedTarget "Abnormally pale skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000980 ; owl:annotatedTarget "Paleness" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0000980 ; owl:annotatedTarget "Skin paleness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000982 ; owl:annotatedTarget "Abnormal thickening of the skin of the palms of the hands and the soles of the feet." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000982 ; owl:annotatedTarget "Thickening of palms and soles" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "chloride" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000987 ; owl:annotatedTarget "Atypically scarred skin ." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000987 ; owl:annotatedTarget "Atypical scarring" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000987 ; owl:annotatedTarget "Atypical scarring of skin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "chloride(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000988 ; owl:annotatedTarget "A red eruption of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000988 ; owl:annotatedTarget "Rash" . [] a owl:Axiom ; rdfs:label "Rash" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0000988 ; owl:annotatedTarget "MEDDRA:10037844" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000988 ; owl:annotatedTarget "Skin rash" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "CHLORIDE ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000989 ; owl:annotatedTarget "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000989 ; owl:annotatedTarget "Itching" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000989 ; owl:annotatedTarget "Itchy skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000989 ; owl:annotatedTarget "Skin itching" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000991 ; owl:annotatedTarget "The presence of multiple xanthomas (xanthomata) in the skin. Xanthomas are yellowish, firm, lipid-laden nodules in the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000991 ; owl:annotatedTarget "Yellow bumps of fatty deposits on skin" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133251 ; owl:annotatedTarget "a 3-hydroxy dicarboxylic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Chloride ion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "An increased sensitivity of the skin to light. Photosensitivity may result in a rash upon exposure to the sun (which is known as photodermatosis). Photosensitivity can be diagnosed by phototests in which light is shone on small areas of skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Photosensitive skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Photosensitive skin rashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Photosensitivity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Sensitivity to sunlight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Skin photosensitivity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000992 ; owl:annotatedTarget "Sun sensitivity" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Chloride(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000993 ; owl:annotatedTarget "Bluish-grey, spongy nodules associated with scars over pressure points and easily traumatized areas like the elbows and knees." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000995 ; owl:annotatedTarget "A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000995 ; owl:annotatedTarget "Noncancerous mole" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000995 ; owl:annotatedTarget "Beauty mark" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Chlorine anion" . [] oboInOwl:hasDbXref "PMID:12186179" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000997 ; owl:annotatedTarget "The presence in the axillary region (armpit) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000998 ; owl:annotatedTarget "Hypertrichosis is increased hair growth that is abnormal in quantity or location." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Cl(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000998 ; owl:annotatedTarget "Excessive hair growth" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0000998 ; owl:annotatedTarget "Increased hair growth on body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0000999 ; owl:annotatedTarget "Any manifestation of a skin disease associated with the production of pus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0000999 ; owl:annotatedTarget "Pus-filled lesion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_17996 ; owl:annotatedTarget "Cl-" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "An abnormality of the pigmentation of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormal pigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormal skin color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormal skin colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormal skin pigmentation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18059 ; owl:annotatedTarget "Lipid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormality of pigmentation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Abnormality of skin pigmentation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Pigmentary changes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Pigmentary skin changes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001000 ; owl:annotatedTarget "Pigmentation anomaly" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18059 ; owl:annotatedTarget "lipids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001001 ; owl:annotatedTarget "Abnormality of fatty tissue below the skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001003 ; owl:annotatedTarget "Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001003 ; owl:annotatedTarget "Liver spots" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "Glycosaminoglycan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001004 ; owl:annotatedTarget "Localized fluid retention and tissue swelling caused by a compromised lymphatic system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001004 ; owl:annotatedTarget "Lymphatic obstruction" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001004 ; owl:annotatedTarget "Swelling caused by excess lymph fluid under skin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "glycosaminoglycan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001007 ; owl:annotatedTarget "Abnormally increased hair growth referring to a male pattern of body hair (androgenic hair)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001007 ; owl:annotatedTarget "Excessive hairiness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "Glykosaminoglykan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001009 ; owl:annotatedTarget "Telangiectasias refer to small dilated blood vessels located near the surface of the skin or mucous membranes, measuring between 0.5 and 1 millimeter in diameter. Telangiectasia are located especially on the tongue, lips, palate, fingers, face, conjunctiva, trunk, nail beds, and fingertips." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001009 ; owl:annotatedTarget "Spider veins" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133291 ; owl:annotatedTarget "a saturated dicarboxylic acid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "glicosaminoglicano" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001010 ; owl:annotatedTarget "A reduction of skin color related to a decrease in melanin production and deposition." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001010 ; owl:annotatedTarget "Patchy lightened skin" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "glycosaminoglycane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001012 ; owl:annotatedTarget "The presence of multiple lipomas (a type of benign tissue made of fatty tissue)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001012 ; owl:annotatedTarget "Multiple fatty lumps" . [] oboInOwl:hasDbXref "PMID:12165227", "PMID:22375975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001013 ; owl:annotatedTarget "Eruptive xanthomas are yellow-orange-to-red-brown papules that are often surrounded by an erythematous halo. They appear in crops on the buttocks, extensor surfaces of the extremities, and flexural creases. Acutely, variable amounts of pruritus and pain occur." . [] oboInOwl:hasDbXref , "PMID:8993949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001014 ; owl:annotatedTarget "Angiokeratomas are hyperkeratotic papules that are characterized histologically by superficial ectatic (i.e., dilated) blood vessels with epidermal proliferation. Clinically, angiokeratoma presents as a small, raised, dark-red spot." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18085 ; owl:annotatedTarget "glycosaminoglycans" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001015 ; owl:annotatedTarget "Prominent veins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001017 ; owl:annotatedTarget "A type of pallor that is secondary to the presence of anemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001017 ; owl:annotatedTarget "Anaemic pallor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001018 ; owl:annotatedTarget "An abnormality of the dermatoglyphs, i.e., an abnormality of the patterns of ridges of the skin of palm of hand." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001019 ; owl:annotatedTarget "An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001019 ; owl:annotatedTarget "Red scaly skin caused by inflammatory skin disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001019 ; owl:annotatedTarget "Exfoliative dermititis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001019 ; owl:annotatedTarget "Generalised erythroderma" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001019 ; owl:annotatedTarget "Generalised erythrodermia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001022 ; owl:annotatedTarget "An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001022 ; owl:annotatedTarget "Achromasia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001022 ; owl:annotatedTarget "Albinism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001025 ; owl:annotatedTarget "Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure." . [] a owl:Axiom ; rdfs:label "Urticaria" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001025 ; owl:annotatedTarget "MEDDRA:10046735" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001025 ; owl:annotatedTarget "Hives" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001026 ; owl:annotatedTarget "Penetrating foot ulcers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001027 ; owl:annotatedTarget "Soft, doughy skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001028 ; owl:annotatedTarget "A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001028 ; owl:annotatedTarget "Strawberry mark" . [] oboInOwl:hasDbXref , "PMID:32363096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001029 ; owl:annotatedTarget "Poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias." . [] a owl:Axiom ; rdfs:label "Poikiloderma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001029 ; owl:annotatedTarget "MEDDRA:10057041" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001030 ; owl:annotatedTarget "Skin that splits easily with minimal injury." . [] a owl:Axiom ; rdfs:label "Skin fragility" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001030 ; owl:annotatedTarget "MEDDRA:10040851" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "CAS:495-69-2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001030 ; owl:annotatedTarget "Fragile skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001030 ; owl:annotatedTarget "Skin fragility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001031 ; owl:annotatedTarget "The presence of subcutaneous lipoma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001032 ; owl:annotatedTarget "Absence of the distal interphalangeal flexion creases of the fingers." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001033 ; owl:annotatedTarget "Facial flushing after alcohol intake" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001034 ; owl:annotatedTarget "A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001034 ; owl:annotatedTarget "Hyperpigmented spots" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001034 ; owl:annotatedTarget "Hyperpigmented skin patches" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "CAS:495-69-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001036 ; owl:annotatedTarget "Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "CAS:495-69-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Blushed cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Blushing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Red face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Red in the face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Rosacea" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001041 ; owl:annotatedTarget "Ruddy face" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:14646363" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001043 ; owl:annotatedTarget "Prominent scalp veins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001045 ; owl:annotatedTarget "Blotchy loss of skin color" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133291 ; owl:annotatedTarget "saturated dicarboxylate(2-)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:15879000" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001045 ; owl:annotatedTarget "Blotchy loss of skin colour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001046 ; owl:annotatedTarget "Jaundice that is sometimes present, sometimes not." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001046 ; owl:annotatedTarget "Intermittent icterus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001046 ; owl:annotatedTarget "Intermittent yellow skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001046 ; owl:annotatedTarget "Intermittent yellowing of skin" . [] oboInOwl:hasDbXref , "PMID:27904186" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001047 ; owl:annotatedTarget "Atopic dermatitis (AD) or atopic eczema is an itchy, inflammatory skin condition with a predilection for the skin flexures. It is characterized by poorly defined erythema with edema, vesicles, and weeping in the acute stage and skin thickening (lichenification) in the chronic stage." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001047 ; owl:annotatedTarget "Baby eczema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001048 ; owl:annotatedTarget "The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma." . [] a owl:Axiom ; rdfs:label "Haemangioma cavernous" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001048 ; owl:annotatedTarget "MEDDRA:10055899" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001048 ; owl:annotatedTarget "Cavernous angioma" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:16760132" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001048 ; owl:annotatedTarget "Collection of dilated blood vessels that forms mass" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001051 ; owl:annotatedTarget "Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk." . [] oboInOwl:hasDbXref , "PMID:22483320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001052 ; owl:annotatedTarget "A congenital vascular malformation consisting of superficial and deep dilated capillaries in the skin which produce a reddish to purplish discolouration of the skin." . [] a owl:Axiom ; rdfs:label "Naevus flammeus" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001052 ; owl:annotatedTarget "MEDDRA:10067193" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001052 ; owl:annotatedTarget "Nevus simplex" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001052 ; owl:annotatedTarget "port-wine stain" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001053 ; owl:annotatedTarget "Patchy loss of skin color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001053 ; owl:annotatedTarget "Patchy loss of skin colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001054 ; owl:annotatedTarget "Numerous moles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001055 ; owl:annotatedTarget "Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:17190852" . [] a owl:Axiom ; rdfs:label "Erysipelas" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001055 ; owl:annotatedTarget "MEDDRA:10015145" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001056 ; owl:annotatedTarget "Presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001056 ; owl:annotatedTarget "Milk spot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001056 ; owl:annotatedTarget "Millium cyst" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "A developmental defect resulting in the congenital absence of skin in multiple or solitary non-inflammatory, well-demarcated, oval or circular ulcers with a diameter of about 1 to 2 cm. Aplasia cutis congenita most commonly occurs on the scalp, but may present in the face, trunk, or limbs." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/aplasia_cutis_congenita" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "Congenital scars" . [] a owl:Axiom ; rdfs:label "Aplasia cutis congenita" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "MEDDRA:10002963" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "Absence of part of skin at birth" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/aplasia_cutis_congenita" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "Congenital absence of skin" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/aplasia_cutis_congenita" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001057 ; owl:annotatedTarget "Cutis aplasia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:19283696" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001058 ; owl:annotatedTarget "A reduced ability to heal cutaneous wounds." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001058 ; owl:annotatedTarget "Poor wound healing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001059 ; owl:annotatedTarget "Pterygia are 'winglike' triangular membranes occurring in the neck, eyes, knees, elbows, ankles or digits." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001060 ; owl:annotatedTarget "Axillary pterygia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001061 ; owl:annotatedTarget "A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001061 ; owl:annotatedTarget "Breaking out" . [] a owl:Axiom ; rdfs:label "Acne" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001061 ; owl:annotatedTarget "MEDDRA:10000496" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001061 ; owl:annotatedTarget "Acne" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001062 ; owl:annotatedTarget "A large pigmented lesion measuring 5-15 mm in diameter with irregular, notched, and ill defined border and with color that may range from tan to dark brown to pink." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001062 ; owl:annotatedTarget "Atypical mole" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:19891605" . [] oboInOwl:hasDbXref "PMID:32644593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001063 ; owl:annotatedTarget "Bluish discoloration of the skin of the hands or feet." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001063 ; owl:annotatedTarget "Persistent blue color of hands or feet" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001063 ; owl:annotatedTarget "Persistent blue colour of hands or feet" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001065 ; owl:annotatedTarget "Thinned, erythematous, depressed bands of atrophic skin. Initially, striae appear as flattened and thinned, pinkish linear regions of the skin. Striae tend to enlarge in length and become reddish or purplish. Later, striae tend to appear as white, depressed bands that are parallel to the lines of skin tension. Striae distensae occur most often in areas that have been subject to distension such as the lower back, buttocks, thighs, breast, abdomen, and shoulders." . [] a owl:Axiom ; rdfs:label "Skin striae" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001065 ; owl:annotatedTarget "MEDDRA:10040925" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001065 ; owl:annotatedTarget "Stretch marks" . [] oboInOwl:hasDbXref , "PMID:30969529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001067 ; owl:annotatedTarget "A benign peripheral nerve sheath tumor that generally appears as a soft, skin-colored papule or small subcutaneous nodule. Individuals with neurofibromatosis can have numerous neurofibromas." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001069 ; owl:annotatedTarget "Intermittent episodes of abnormally increased perspiration." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001069 ; owl:annotatedTarget "Sporadic excessive sweating" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001070 ; owl:annotatedTarget "Patchy and irregular skin pigmentation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:20405919" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001070 ; owl:annotatedTarget "Mottled skin coloring" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001070 ; owl:annotatedTarget "Mottled skin colouring" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001071 ; owl:annotatedTarget "Fabry syndrome" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001072 ; owl:annotatedTarget "Laminar thickening of skin." . [] a owl:Axiom ; rdfs:label "Skin thickening" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001072 ; owl:annotatedTarget "MEDDRA:10040936" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001072 ; owl:annotatedTarget "Thick skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001072 ; owl:annotatedTarget "Thickened skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001072 ; owl:annotatedTarget "Diffusely thickened skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001073 ; owl:annotatedTarget "Thin (atrophic) and wide scars." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001073 ; owl:annotatedTarget "Cigarette paper scarring" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001073 ; owl:annotatedTarget "Cigarette-paper scars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001075 ; owl:annotatedTarget "Scars that form a depression compared to the level of the surrounding skin because of damage to the collagen, fat or other tissues below the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001075 ; owl:annotatedTarget "Sunken or indented skin due to damage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:7153346" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001080 ; owl:annotatedTarget "An abnormality of the biliary tree." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001081 ; owl:annotatedTarget "Hard, pebble-like deposits that form within the gallbladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001081 ; owl:annotatedTarget "Gallstones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:8734460" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001082 ; owl:annotatedTarget "The presence of inflammatory changes in the gallbladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001082 ; owl:annotatedTarget "Gallbladder inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001083 ; owl:annotatedTarget "Dislocation or malposition of the crystalline lens of the eye. A partial displacement (or dislocation) of the lens is described as a subluxation of the lens, while a complete displacement is termed luxation of the lens. A complete displacement occurs if the lens is completely outside the patellar fossa of the lens, either in the anterior chamber, in the vitreous, or directly on the retina. If the lens is partially displaced but still contained within the lens space, then it is termed subluxation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:9120876" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001084 ; owl:annotatedTarget "A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001085 ; owl:annotatedTarget "Papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001087 ; owl:annotatedTarget "Childhood glaucoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001087 ; owl:annotatedTarget "Infantile glaucoma" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001087 ; owl:annotatedTarget "Paediatric glaucoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001087 ; owl:annotatedTarget "Pediatric glaucoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001088 ; owl:annotatedTarget "The presence of whitish spots in a ring-like arrangement at the periphery of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001088 ; owl:annotatedTarget "Speckled iris" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "PMID:9609721" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001089 ; owl:annotatedTarget "Loss of iris tissue (atrophy)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001089 ; owl:annotatedTarget "Iris degeneration" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Reaxys:1073987" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Diffusely large eye (with megalocornea) without glaucoma." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Increased size of eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Large eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Increased size of palpebral fissures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Large eyeballs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001090 ; owl:annotatedTarget "Large of palpebral fissures" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "N-Benzoylglycine" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001092 ; owl:annotatedTarget "No identifiable superior and/or inferior lacrimal punctum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "N-benzoylglycine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001093 ; owl:annotatedTarget "The presence of developmental dysplasia of the optic nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001094 ; owl:annotatedTarget "A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001096 ; owl:annotatedTarget "Inflammation of the cornea and conjunctiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001097 ; owl:annotatedTarget "Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001097 ; owl:annotatedTarget "Dry eyes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "N-benzoylglycine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001097 ; owl:annotatedTarget "Dry eye syndrome" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Benzamidoacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001100 ; owl:annotatedTarget "Heterochromia iridis is a difference in the color of the iris in the two eyes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001100 ; owl:annotatedTarget "Different colored eyes" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001100 ; owl:annotatedTarget "Different coloured eyes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Benzamidoessigsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001101 ; owl:annotatedTarget "Inflammation of the iris." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Benzoylaminoacetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001101 ; owl:annotatedTarget "Inflammation of iris" . [] oboInOwl:hasDbXref , , "PMID:30844178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001102 ; owl:annotatedTarget "Irregular lines in the deep retina that are typically configured in a radiating fashion and emanate from the optic disc. Angioid streaks are crack-like dehiscences in abnormally thickened and calcified Bruch's membrane, resulting in atrophy of the overlying retinal pigment epithelium. They may be associated with a number of endocrine, metabolic, and connective tissue abnormalities but are frequently idiopathic." . [] oboInOwl:hasDbXref , "PMID:16255686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001103 ; owl:annotatedTarget "A structural abnormality of the macula lutea, which is an oval-shaped highly pigmented yellow spot near the center of the retina." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Benzoylaminoessigsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001104 ; owl:annotatedTarget "Underdevelopment of the macula lutea." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Hippurate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001105 ; owl:annotatedTarget "Well-demarcated area(s) of partial or complete depigmentation in the fundus, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133294 ; owl:annotatedTarget "oxo dicarboxylic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Hippuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Increased pigmentation of the skin in the region surrounding the orbit of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Dark circles around the eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Dark circles under the eyes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Hippursaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Darkening around the eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Idiopathic cutaneous hyperchromia at the orbital region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Infraorbital pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Periorbital melanosis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001106 ; owl:annotatedTarget "Pigmentation around the eyes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18089 ; owl:annotatedTarget "Phenylcarbonylaminoacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001107 ; owl:annotatedTarget "An abnormal reduction in the amount of pigmentation (reduced or absent) of the iris and retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001107 ; owl:annotatedTarget "Absent pigmentation in the eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001112 ; owl:annotatedTarget "Degeneration of retinal ganglion cells and their axons." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001112 ; owl:annotatedTarget "Leber optic degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "The presence of xanthomata in the skin of the eyelid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Fatty deposits in skin around the eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Fatty deposits on eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthelasma palpebrarum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthelasma of eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthelasma of periocular region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthoma of eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001114 ; owl:annotatedTarget "Xanthoma of periocular region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001115 ; owl:annotatedTarget "A polar cataract that affects the posterior pole of the lens." . [] oboInOwl:hasDbXref , "PMID:15069441" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001116 ; owl:annotatedTarget "A congenital defect of the macula distinct from coloboma associated with optic fissure closure defects. Macular coloboma is characterized by a sharply defined, rather large defect in the central area of the fundus that is oval or round, and coarsely pigmented." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001117 ; owl:annotatedTarget "Severe loss of visual acuity within hours or days. This is characteristic of Leber hereditary optic neuropathy." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001117 ; owl:annotatedTarget "Sudden decrease in vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001118 ; owl:annotatedTarget "A type of cataract that is not apparent at birth but that arises in childhood or adolescence." . [] oboInOwl:hasDbXref "PMID:19667340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001119 ; owl:annotatedTarget "Limbus-to-limbus corneal thinning, often greatest in the periphery, with globular protrusion of the cornea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001120 ; owl:annotatedTarget "Any abnormality of the size or morphology of the cornea." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001123 ; owl:annotatedTarget "Partial loss of field of vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001123 ; owl:annotatedTarget "Visual field defects" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001125 ; owl:annotatedTarget "Transient blurring of vision associated with the aura phase of migraine." . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001126 ; owl:annotatedTarget "Cryptophthalmos is a condition of total absence of eyelids and the skin of forehead is continuous with that of cheek, in which the eyeball is completely concealed by the skin, which is stretched over the orbital cavity." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "CAS:51-35-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001128 ; owl:annotatedTarget "Inversion and rubbing of the eyelashes against the globe of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001128 ; owl:annotatedTarget "Ingrown eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001128 ; owl:annotatedTarget "Introversion of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001129 ; owl:annotatedTarget "Large central loss of field of vision" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "CAS:51-35-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001131 ; owl:annotatedTarget "The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "CAS:51-35-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001132 ; owl:annotatedTarget "Partial dislocation of the lens of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001132 ; owl:annotatedTarget "Partially dislocated lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001133 ; owl:annotatedTarget "An absolute or relative decrease in retinal sensitivity extending from edge (periphery) of the visual field in a concentric pattern. The visual field is the area that is perceived simultaneously by a fixating eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001133 ; owl:annotatedTarget "Constricted visual fields" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001133 ; owl:annotatedTarget "Limited peripheral vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001134 ; owl:annotatedTarget "A polar cataract that affects the anterior pole of the lens." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133294 ; owl:annotatedTarget "oxo dicarboxylic acid dianions" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Drug_Central:4272" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:1117843" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001136 ; owl:annotatedTarget "The presence of an increased number of twists and turns of the retinal arterioles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001137 ; owl:annotatedTarget "Esotropia in which either eye may be used for fixation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001137 ; owl:annotatedTarget "Alternating cross eyes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:1166829" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001138 ; owl:annotatedTarget "Damaged optic nerve" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001140 ; owl:annotatedTarget "A benign tumor typically found at the junction of the cornea and sclera (limbal epibullar dermoid)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001140 ; owl:annotatedTarget "Benign eye tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001140 ; owl:annotatedTarget "Benign eye tumour" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001140 ; owl:annotatedTarget "Epibulbar dermoids" . [] oboInOwl:hasDbXref "PMID:28779882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001141 ; owl:annotatedTarget "Severe reduction of the ability to see defined as visual acuity less than 6/60 (20/200 in US notation; 0.1 in decimal notation) but at least 3/60 (20/400 in US notation; 0.05 in decimal notation)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001141 ; owl:annotatedTarget "Marked vision impairment" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:12148113" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001141 ; owl:annotatedTarget "Severe visual impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001141 ; owl:annotatedTarget "Severely impaired vision" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001142 ; owl:annotatedTarget "A conical projection of the anterior or posterior surface of the lens, occurring as a developmental anomaly." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:14104082" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001144 ; owl:annotatedTarget "Presence of a cyst in the region of the periorbital tissues. Orbital cysts can be derived from epithelial or glandular tissue within or surrounding the orbit (lacrimal glands, salivary glands, conjunctival, oral, nasal, or sinus epithelium)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001144 ; owl:annotatedTarget "Cyst of eye socket" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001147 ; owl:annotatedTarget "Fluid which has escaped from retinal blood vessels with a high concentration of lipid, protein, and cellular debris with a typically bright, reflective, white or cream colored appearance on the surface of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001149 ; owl:annotatedTarget "The presence of fine, branching linear opacities in Bowman's layer in the central area that may spread to the periphery in the clinical course. The deep corneal stroma may be involved but the process does not reach Descemet's membrane. Recurrent corneal erosion may occur. Histologic examination reveals amyloid deposits in the collagen fibers of the cornea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001149 ; owl:annotatedTarget "Biber haab dimmer dystrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001151 ; owl:annotatedTarget "An abnormality of ocular smooth pursuit characterized by an impairment of the ability to track horizontally moving objects." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001152 ; owl:annotatedTarget "An abnormality of tracking eye movements in which smooth pursuit is interrupted by an abnormally high number of saccadic movements." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:14995121" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001153 ; owl:annotatedTarget "The presence of a vaginal septum, thereby creating a vaginal duplication. The septum is longitudinal in the majority of cases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001153 ; owl:annotatedTarget "Double vagina" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:15558350" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001155 ; owl:annotatedTarget "An abnormality affecting one or both hands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001155 ; owl:annotatedTarget "Abnormal hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001155 ; owl:annotatedTarget "Abnormality of the hand" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001155 ; owl:annotatedTarget "Hand anomalies" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001155 ; owl:annotatedTarget "Hand deformities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001156 ; owl:annotatedTarget "Digits that appear disproportionately short compared to the hand/foot. The word brachydactyly is used here to describe a series distinct patterns of shortened digits (brachydactyly types A-E). This is the sense used here." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001156 ; owl:annotatedTarget "Short fingers or toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:16096557" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001159 ; owl:annotatedTarget "Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are referred to as \"symphalangism\"." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001159 ; owl:annotatedTarget "Webbed fingers or toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:16656634" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001161 ; owl:annotatedTarget "A kind of polydactyly characterized by the presence of a supernumerary finger or fingers." . [] a owl:Axiom ; rdfs:label "Polydactyly of fingers" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001161 ; owl:annotatedTarget "MEDDRA:10036064" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001161 ; owl:annotatedTarget "Extra finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:16662024" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001161 ; owl:annotatedTarget "Supernumerary finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:16665943" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001162 ; owl:annotatedTarget "Supernumerary digits located at the ulnar side of the hand (that is, on the side with the fifth finger)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001162 ; owl:annotatedTarget "Extra little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001162 ; owl:annotatedTarget "Extra pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001162 ; owl:annotatedTarget "Extra pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001166 ; owl:annotatedTarget "Abnormally long and slender fingers (\"spider fingers\")." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001166 ; owl:annotatedTarget "Long slender fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001166 ; owl:annotatedTarget "Spider fingers" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:17021603" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:19286848" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001167 ; owl:annotatedTarget "An anomaly of a finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001167 ; owl:annotatedTarget "Abnormalities of the fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001167 ; owl:annotatedTarget "Abnormality of finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:590925" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001169 ; owl:annotatedTarget "For children from birth to 4 years of age the palm width is more than 2 SD above the mean; for children from 4 to 16 years of age the palm width is above the 95th centile; or, the width of the palm appears disproportionately wide for the length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001169 ; owl:annotatedTarget "Broad hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001169 ; owl:annotatedTarget "Broad hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001169 ; owl:annotatedTarget "Broad palm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001169 ; owl:annotatedTarget "Wide palm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001171 ; owl:annotatedTarget "A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middel fingers as far as oligo- or monodactyl hands." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001171 ; owl:annotatedTarget "Split hand" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001171 ; owl:annotatedTarget "Split-hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:616023" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001172 ; owl:annotatedTarget "Abnormality of the thumb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001172 ; owl:annotatedTarget "Abnormality of the thumbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001172 ; owl:annotatedTarget "Thumb deformity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:6616407" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001176 ; owl:annotatedTarget "Large hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001176 ; owl:annotatedTarget "large hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:6625779" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001177 ; owl:annotatedTarget "Supernumerary digits located at the radial side of the hand. Polydactyly (supernumerary digits) involving the thumb occurs in many distinct forms of high variability and severity. Ranging from fleshy nubbins over varying degrees of partial duplication/splitting to completely duplicated or even triplicated thumbs or preaxial (on the radial side of the hand) supernumerary digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001177 ; owl:annotatedTarget "Extra thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:6783274" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001177 ; owl:annotatedTarget "Supernumerary thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001178 ; owl:annotatedTarget "An abnormal hand position characterized by hyperextension of the fourth and fifth fingers at the metacarpophalangeal joints and flexion of the interphalangeal joints of the same fingers such that they are curled towards the palm." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:7248905" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001180 ; owl:annotatedTarget "A developmental defect resulting in the presence of fewer than the normal number of fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001180 ; owl:annotatedTarget "Hand has less than 5 fingers" . [] oboInOwl:hasDbXref , "PMID:16235349", "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001181 ; owl:annotatedTarget "In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001181 ; owl:annotatedTarget "Inward turned thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:7283558" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001182 ; owl:annotatedTarget "The gradual reduction in girth of the finger from proximal to distal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001182 ; owl:annotatedTarget "Tapered finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001182 ; owl:annotatedTarget "Tapered fingertips" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001182 ; owl:annotatedTarget "Tapering fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001182 ; owl:annotatedTarget "Tapered fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001187 ; owl:annotatedTarget "The ability of the finger joints to move beyond their normal range of motion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:7446210" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001187 ; owl:annotatedTarget "Finger joint hyperextensibility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001187 ; owl:annotatedTarget "Hyperextensible digits" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001187 ; owl:annotatedTarget "Hyperextensible finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001187 ; owl:annotatedTarget "Hyperextensible fingers" . [] oboInOwl:hasDbXref , "PMID:10085502", "PMID:16702456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001188 ; owl:annotatedTarget "An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001188 ; owl:annotatedTarget "Clenched hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001188 ; owl:annotatedTarget "Hand clenching" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:899882" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001191 ; owl:annotatedTarget "An abnormality affecting the carpal bones of the wrist (scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate, hamate)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001191 ; owl:annotatedTarget "Abnormal wrist bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "PMID:946341" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001194 ; owl:annotatedTarget "An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001194 ; owl:annotatedTarget "Abnormalities of placenta or umbilical cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "2 vessel cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "2 vessel umbilical cord" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "Only one artery in umbilical cord instead of two" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "Two vessel cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001195 ; owl:annotatedTarget "Two vessel umbilical cord" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Reaxys:81441" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001196 ; owl:annotatedTarget "Decreased length of the umbilical cord." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001196 ; owl:annotatedTarget "Short umbilical cord" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "(4R)-4-hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001197 ; owl:annotatedTarget "An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001197 ; owl:annotatedTarget "Abnormality of prenatal development or birth" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001199 ; owl:annotatedTarget "A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001199 ; owl:annotatedTarget "Finger-like thumb" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "trans-4-Hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001204 ; owl:annotatedTarget "The term distal symphalangism refers to a bony fusion of the distal and middle phalanges of the digits of the hand, in other words the distal interphalangeal joint (DIJ) is missing which can be seen either on x-rays or as an absence of the distal interphalangeal finger creases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001204 ; owl:annotatedTarget "Fused outermost bones of hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "trans-4-hydroxy-L-proline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001211 ; owl:annotatedTarget "Abnormality of the fingertips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001212 ; owl:annotatedTarget "A soft tissue prominence of the ventral aspects of the fingertips. The term \"persistent fetal fingertip pads\" is often used as a synonym, but should better not be used because it implies knowledge of history of the patient which often does not exist." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001212 ; owl:annotatedTarget "Persistent foetal fingertip pads" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001212 ; owl:annotatedTarget "Prominent finger pads" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001212 ; owl:annotatedTarget "Prominent fingertip pads" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001215 ; owl:annotatedTarget "The distal interphalangeal joint and/or the proximal interphalangeal joint of the second to fifth fingers cannot be extended to 180 degrees by either active or passive extension." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "(2S,4R)-trans-4-hydroxyproline" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001216 ; owl:annotatedTarget "Ossification of carpal bones occurs later than age-adjusted norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001216 ; owl:annotatedTarget "Delayed maturation of wrist bone" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001217 ; owl:annotatedTarget "Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_133580 ; owl:annotatedTarget "(hexanoylamino)acetate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Hydroxyproline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001217 ; owl:annotatedTarget "Clubbing of fingers and toes" . [] oboInOwl:hasDbXref , "PMID:31633102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001218 ; owl:annotatedTarget "Auto-amputation is the spontaneous detachment of an appendage from the body due to long standing pathology." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001220 ; owl:annotatedTarget "Chronic loss of joint motion in an interphalangeal joint of a finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Hyp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001222 ; owl:annotatedTarget "Spoon-shaped, broad thumbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001222 ; owl:annotatedTarget "Spoon shaped thumbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001223 ; owl:annotatedTarget "All of the metacarpal bones of the hand have a pointed proximal appearance." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "Hypro" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001225 ; owl:annotatedTarget "Wrist swelling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001227 ; owl:annotatedTarget "An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "L-4-Hydroxyproline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001230 ; owl:annotatedTarget "Abnormally broad metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001230 ; owl:annotatedTarget "Wide long bones of hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "L-threo-4-hydroxyproline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001231 ; owl:annotatedTarget "An abnormality of the fingernails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001231 ; owl:annotatedTarget "Abnormal fingernails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001231 ; owl:annotatedTarget "Abnormality of the fingernails" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "delta-hydroxyproline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001232 ; owl:annotatedTarget "Telangiectases in the area of the nails." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "trans-Hydroxyproline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001233 ; owl:annotatedTarget "Syndactyly with fusion of fingers two and three." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18095 ; owl:annotatedTarget "trans-L-Hydroxyproline" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001233 ; owl:annotatedTarget "Webbed 2nd-3rd fingers" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001234 ; owl:annotatedTarget "With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001234 ; owl:annotatedTarget "Hitchhiker thumb" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001238 ; owl:annotatedTarget "Fingers that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001238 ; owl:annotatedTarget "Narrow fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001238 ; owl:annotatedTarget "Slender finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001238 ; owl:annotatedTarget "Slender fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001238 ; owl:annotatedTarget "thin fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001239 ; owl:annotatedTarget "A chronic loss of wrist joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevent normal movement of the joints of the wrist." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133580 ; owl:annotatedTarget "N-caproylglycinate" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001245 ; owl:annotatedTarget "Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001245 ; owl:annotatedTarget "Decreased thenar eminence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001248 ; owl:annotatedTarget "Decreased length of the tubular bones of the hand, that is, the phalanges and metacarpals." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Intellectual disability" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Mental deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Mental retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Mental retardation, nonspecific" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Mental-retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Low intelligence" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001249 ; owl:annotatedTarget "Poor school performance" . [] oboInOwl:hasDbXref , "PMID:15816939" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001250 ; owl:annotatedTarget "A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain." . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001250 ; owl:annotatedTarget "Seizures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001250 ; owl:annotatedTarget "Epilepsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001251 ; owl:annotatedTarget "Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly)." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "CAS:156-38-7" . [] oboInOwl:hasDbXref , "PMID:21418198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001252 ; owl:annotatedTarget "Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001252 ; owl:annotatedTarget "Low muscle tone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001252 ; owl:annotatedTarget "Low or weak muscle tone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001254 ; owl:annotatedTarget "A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001254 ; owl:annotatedTarget "Lethargy" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "CAS:156-38-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Mild intellectual disability is defined as an intelligence quotient (IQ) in the range of 50-69." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Intellectual disability, mild" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Mental retardation, borderline-mild" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Mild and nonprogressive mental retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Mild mental retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001256 ; owl:annotatedTarget "Mental retardation, mild" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001257 ; owl:annotatedTarget "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001257 ; owl:annotatedTarget "Involuntary muscle stiffness, contraction, or spasm" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "CAS:156-38-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001258 ; owl:annotatedTarget "Spasticity and weakness of the leg and hip muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001259 ; owl:annotatedTarget "Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli." . [] a owl:Axiom ; rdfs:label "Coma, unspecified" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001259 ; owl:annotatedTarget "ICD-10:R40.2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001259 ; owl:annotatedTarget "Coma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001260 ; owl:annotatedTarget "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001260 ; owl:annotatedTarget "Difficulty articulating speech" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001262 ; owl:annotatedTarget "Excessive daytime sleepiness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001262 ; owl:annotatedTarget "More than typical sleepiness during day" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001263 ; owl:annotatedTarget "A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001264 ; owl:annotatedTarget "Spasticity (neuromuscular hypertonia) primarily in the muscles of the legs, hips, and pelvis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:11339992" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001265 ; owl:annotatedTarget "Reduction of neurologic reflexes such as the knee-jerk reaction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001265 ; owl:annotatedTarget "Decreased reflex response" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001265 ; owl:annotatedTarget "Decreased reflexes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:21476434" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001266 ; owl:annotatedTarget "Involuntary movements characterized by both athetosis (inability to sustain muscles in a fixed position) and chorea (widespread jerky arrhythmic movements)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Loss of previously present mental abilities, generally in adults." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Cognitive decline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Cognitive decline, progressive" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Intellectual deterioration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Mental deterioration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001268 ; owl:annotatedTarget "Progressive cognitive decline" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UKB_tklockgether" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001269 ; owl:annotatedTarget "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001269 ; owl:annotatedTarget "Weakness of one side of body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001270 ; owl:annotatedTarget "A type of Developmental delay characterized by a delay in acquiring motor skills." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:22296160" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001271 ; owl:annotatedTarget "A generalized disorder of peripheral nerves." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001271 ; owl:annotatedTarget "Peripheral nerve disease" . [] oboInOwl:hasDbXref , "PMID:12169461", "PMID:26331051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001272 ; owl:annotatedTarget "Cerebellar atrophy is defined as a cerebellum with initially normal structures, in a posterior fossa with normal size, which displays enlarged fissures (interfolial spaces) in comparison to the foliae secondary to loss of tissue. Cerebellar atrophy implies irreversible loss of tissue and result from an ongoing progressive disease until a final stage is reached or a single injury, e.g. an intoxication or infectious event." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133580 ; owl:annotatedTarget "N-hexanoylglycine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:24636068" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001272 ; owl:annotatedTarget "Degeneration of cerebellum" . [] oboInOwl:hasDbXref , "PMID:21263138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001273 ; owl:annotatedTarget "Abnormality of the corpus callosum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:24831010" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001274 ; owl:annotatedTarget "Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:7126379" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001276 ; owl:annotatedTarget "A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001276 ; owl:annotatedTarget "Spasticity and rigidity of muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001278 ; owl:annotatedTarget "A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001278 ; owl:annotatedTarget "Decrease in blood pressure upon standing up" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001279 ; owl:annotatedTarget "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001279 ; owl:annotatedTarget "Fainting spell" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "PMID:977696" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001281 ; owl:annotatedTarget "Intermittent involuntary muscle spasm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001283 ; owl:annotatedTarget "Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001284 ; owl:annotatedTarget "Absence of neurologic reflexes such as the knee-jerk reaction." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "Reaxys:1448766" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001284 ; owl:annotatedTarget "Absent reflexes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001284 ; owl:annotatedTarget "Absent tendon reflexes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001285 ; owl:annotatedTarget "Spastic weakness affecting all four limbs." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "UM-BBD_compID:c0271" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001287 ; owl:annotatedTarget "Inflammation of the meninges." . [] oboInOwl:hasDbXref , "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001288 ; owl:annotatedTarget "The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001288 ; owl:annotatedTarget "Abnormal gait" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001288 ; owl:annotatedTarget "Abnormal walk" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001288 ; owl:annotatedTarget "Impaired gait" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001289 ; owl:annotatedTarget "Lack of clarity and coherence of thought, perception, understanding, or action." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "(4-hydroxyphenyl)acetic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001289 ; owl:annotatedTarget "Confusion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001289 ; owl:annotatedTarget "Disorientation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001289 ; owl:annotatedTarget "Easily confused" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001289 ; owl:annotatedTarget "Mental disorientation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "4-Hydroxyphenylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Generalized muscular hypotonia (abnormally low muscle tone)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Generalised decreased muscle tone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Generalised hypotonia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Generalised muscular hypotonia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Generalized decreased muscle tone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001290 ; owl:annotatedTarget "Hypotonia, generalised" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "(p-hydroxyphenyl)acetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001291 ; owl:annotatedTarget "Structural abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001291 ; owl:annotatedTarget "Abnormality of cranial nerve" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001297 ; owl:annotatedTarget "Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001297 ; owl:annotatedTarget "Stroke" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "4-Hydroxyphenylacetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001297 ; owl:annotatedTarget "Cerebrovascular accidents" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001298 ; owl:annotatedTarget "Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001300 ; owl:annotatedTarget "Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait." . [] oboInOwl:hasDbXref , , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001302 ; owl:annotatedTarget "Pachygyria is a malformation of cortical development with abnormally wide gyri with sulci 1,5-3 cm apart and abnormally thick cortex measuring more than 5 mm (radiological definition). See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001302 ; owl:annotatedTarget "Fewer and broader ridges in brain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001304 ; owl:annotatedTarget "Sustained involuntary muscle contractions that produce twisting and repetitive movements of the body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133580 ; owl:annotatedTarget "N-hexanoylglycine anion" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "4-carboxymethylphenol" . [] oboInOwl:hasDbXref , "PMID:26246090" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001305 ; owl:annotatedTarget "A congenital brain malformation typically characterized by incomplete formation of the cerebellar vermis, dilation of the fourth ventricle, and enlargement of the posterior fossa. In layman's terms, Dandy Walker malformation is a cyst in the cerebellum (typically symmetrical) that is involved with the fourth ventricle. This may interfere with the ability to drain cerebrospinal fluid from the brain, resulting in hydrocephalus. Dandy Walker cysts are formed during early embryonic development, while the brain forms. The cyst in the cerebellum typically has several blood vessels running through it connecting to the brain, thereby prohibiting surgical removal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Fasciculations or fibrillation affecting the tongue muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Lingual fasciculations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Lingual fibrillations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Lingual twitching" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Tongue twitching" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001308 ; owl:annotatedTarget "Twitching of the tongue" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "4-hydroxybenzeneacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001310 ; owl:annotatedTarget "A type of ataxia characterized by the inability to carry out movements with the correct range and motion across the plane of more than one joint related to incorrect estimation of the distances required for targeted movements." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001310 ; owl:annotatedTarget "Lack of coordination of movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001311 ; owl:annotatedTarget "An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001312 ; owl:annotatedTarget "An abnormal enlargement (i.e. increase in measured voltage) of somatosensory evoked potentials." . [] oboInOwl:hasDbXref , "PMID:20941667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001315 ; owl:annotatedTarget "Diminution of tendon reflexes, which is an invariable sign of peripheral nerve disease." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18101 ; owl:annotatedTarget "p-hydroxyphenylacetic acid" . [] oboInOwl:hasDbXref , "PMID:27160001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001317 ; owl:annotatedTarget "Any structural abnormality of the cerebellum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001317 ; owl:annotatedTarget "Abnormality of the cerebellum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001317 ; owl:annotatedTarget "Cerebellar abnormalities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001317 ; owl:annotatedTarget "Cerebellar abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001317 ; owl:annotatedTarget "Cerebellar anomaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001319 ; owl:annotatedTarget "Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001319 ; owl:annotatedTarget "Low muscle tone, in neonatal onset" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18133 ; owl:annotatedTarget "Hexose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001320 ; owl:annotatedTarget "Underdevelopment of the vermis of cerebellum." . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18133 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" . [] oboInOwl:hasDbXref , "PMID:26331051", "PMID:27160001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001321 ; owl:annotatedTarget "Cerebellar hypoplasia is a descriptive term implying a cerebellum with a reduced volume, but a normal shape and is stable over time." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001321 ; owl:annotatedTarget "Small cerebellum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001321 ; owl:annotatedTarget "Underdeveloped cerebellum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18133 ; owl:annotatedTarget "hexoses" . [] oboInOwl:hasDbXref , "PMID:15832536" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001324 ; owl:annotatedTarget "Reduced strength of muscles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001324 ; owl:annotatedTarget "Muscle weakness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001324 ; owl:annotatedTarget "Muscular weakness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001325 ; owl:annotatedTarget "Coma caused by low blood sugar" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001326 ; owl:annotatedTarget "EEG shows spikes (<80 ms) and waves, which are recorded over the entire scalp and do not have a specific frequency." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001326 ; owl:annotatedTarget "EEG with irregular generalised spike and wave complexes" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001327 ; owl:annotatedTarget "Generalised myoclonic seizure provoked by flashing or flickering light." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001327 ; owl:annotatedTarget "Photomyoclonic seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001328 ; owl:annotatedTarget "Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence." . [] oboInOwl:hasDbXref , "PMID:30725733" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001331 ; owl:annotatedTarget "Absence of the septum pellucidum (meaning translucent wall in Latin - SP), also known as the ventricle of Sylvius. The septum pellucidum is a thin, triangular double membrane separating the frontal horns of the right and left lateral ventricles of the brain. It extends between the anterior portion of the corpus callosum, and the body of the fornix and its width varies from 1.5 to 3.0 mm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001331 ; owl:annotatedTarget "Missing septum pellucidum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001332 ; owl:annotatedTarget "An abnormally increased muscular tone that causes fixed abnormal postures. There is a slow, intermittent twisting motion that leads to exaggerated turning and posture of the extremities and trunk." . [] oboInOwl:hasDbXref , "eMedicine:1135286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001334 ; owl:annotatedTarget "A form of hydrocephalus in which there is no visible obstruction to the flow of the cerebrospinal fluid between the ventricles and subarachnoid space." . [] oboInOwl:hasDbXref , "PMID:22412265", "PMID:28945198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001335 ; owl:annotatedTarget "Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001335 ; owl:annotatedTarget "Hand mirror movements" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001335 ; owl:annotatedTarget "Mirror hand movements" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001335 ; owl:annotatedTarget "Mirror movements" . [] oboInOwl:hasDbXref , "PMID:20589866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001336 ; owl:annotatedTarget "Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001336 ; owl:annotatedTarget "Jerking" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "Beilstein:956566" . [] oboInOwl:hasDbXref , "PMID:16344298", "PMID:20589866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001337 ; owl:annotatedTarget "An unintentional, oscillating to-and-fro muscle movement about a joint axis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001337 ; owl:annotatedTarget "Tremor" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001337 ; owl:annotatedTarget "Tremors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133580 ; owl:annotatedTarget "N-hexanoylglycine(1-)" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "CAS:75-50-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001338 ; owl:annotatedTarget "A partial failure of the development of the corpus callosum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001338 ; owl:annotatedTarget "Partial or complete agenesis of the corpus callosum" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "CAS:75-50-3" . [] oboInOwl:hasDbXref , , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001339 ; owl:annotatedTarget "A spectrum of malformations of cortical development caused by insufficient neuronal migration that subsumes the terms agyria, pachygyria and subcortical band heterotopia. See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001339 ; owl:annotatedTarget "Fewer or absent grooves in brain" . [] oboInOwl:hasDbXref , "PMID:4819909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001340 ; owl:annotatedTarget "Increase in amplitude of a long-loop response upon somatosensory evoked potential testing, representing an electrically evoked myoclonic response." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "CAS:75-50-3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001341 ; owl:annotatedTarget "Olfactory lobe absence" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "Gmelin:1309" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001342 ; owl:annotatedTarget "Hemorrhage into the parenchyma of the brain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001342 ; owl:annotatedTarget "Bleeding in brain" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001342 ; owl:annotatedTarget "Cerebral haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001342 ; owl:annotatedTarget "Intracerebral haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001342 ; owl:annotatedTarget "Hemorrhagic stroke" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001343 ; owl:annotatedTarget "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "Complete lack of development of speech and language abilities." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "Absent speech development" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:14047118" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "Lack of language development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "Lack of speech" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "No speech development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "No speech or language development" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001344 ; owl:annotatedTarget "Nonverbal" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:15304308" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001347 ; owl:annotatedTarget "Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001347 ; owl:annotatedTarget "Increased reflexes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001349 ; owl:annotatedTarget "Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001350 ; owl:annotatedTarget "Abnormal coordination of muscles involved in speech." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001350 ; owl:annotatedTarget "Slurred speech" . [] oboInOwl:hasDbXref , "PMID:1464676", "PMID:30653168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001351 ; owl:annotatedTarget "Jerk-locked averaging (JLA) is used to record the timing and distribution of brain activity preceding brisk involuntary movements such as those observed in patients with myoclonus. JLA is capable of revealing a premyoclonus spike in the absence of paroxysmal activity in the routine EEG." . [] oboInOwl:hasDbXref , , "PMID:28658095", "PMID:29594439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001355 ; owl:annotatedTarget "Diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001355 ; owl:annotatedTarget "Enlarged brain" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:15752091" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Asymmetric head shape, which is usually a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Asymmetry of the posterior cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Asymmetry of the posterior head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Asymmetry of the posterior skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flat head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Rhomboid shaped head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flat head syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flattening of cranial vault" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flattening of cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flattening of skull" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Rhomboid shaped cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Rhomboid shaped skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Deformational plagiocephaly" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Flattening of head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001357 ; owl:annotatedTarget "Positional plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001360 ; owl:annotatedTarget "Holoprosencephaly is a structural anomaly of the brain in which the developing forebrain fails to divide into two separate hemispheres and ventricles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001361 ; owl:annotatedTarget "Head movements associated with nystagmus, that may represent an attempt to compensate for the involuntary eye movements and to improve vision." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:1801314" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001362 ; owl:annotatedTarget "A localized defect in the bone of the skull resulting from abnormal embryological development. The defect is covered by normal skin. In some cases, skull x-rays have shown underlying lytic bone lesions which have closed before the age of one year." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001362 ; owl:annotatedTarget "Cranial defect" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001362 ; owl:annotatedTarget "Skull defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001362 ; owl:annotatedTarget "Calvarial defect" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:24591617" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001363 ; owl:annotatedTarget "Craniosynostosis refers to the premature closure of the cranial sutures. Primary craniosynostosis refers to the closure of one or more sutures due to abnormalities in skull development, and secondary craniosynostosis results from failure of brain growth." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/Craniosynostosis" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001363 ; owl:annotatedTarget "Deformity of the skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001363 ; owl:annotatedTarget "Cranial suture synostosis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:2501587" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001363 ; owl:annotatedTarget "Premature suture closure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001367 ; owl:annotatedTarget "An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001367 ; owl:annotatedTarget "Abnormal shape of joints" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "PMID:5161463" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001367 ; owl:annotatedTarget "Abnormality of the joints" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001367 ; owl:annotatedTarget "Anomaly of the joints" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001367 ; owl:annotatedTarget "Joint disease" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "Reaxys:956566" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001369 ; owl:annotatedTarget "Inflammation of a joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001369 ; owl:annotatedTarget "Arthritis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001369 ; owl:annotatedTarget "Joint inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001370 ; owl:annotatedTarget "Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001370 ; owl:annotatedTarget "RA" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001370 ; owl:annotatedTarget "Rheumatoid arthritis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "N,N-dimethylmethanamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001371 ; owl:annotatedTarget "A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001371 ; owl:annotatedTarget "Flexed joint that cannot be straightened" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "Trimethylamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001373 ; owl:annotatedTarget "Displacement or malalignment of joints." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001373 ; owl:annotatedTarget "Joint dislocation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001373 ; owl:annotatedTarget "Joint dislocations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001374 ; owl:annotatedTarget "Dislocated hip since birth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "(CH3)3N" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "A reduction in the freedom of movement of one or more joints." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "Decreased joint mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "Decreased mobility of joints" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "N(CH3)3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "Limitation of joint mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "Limited joint mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001376 ; owl:annotatedTarget "Limited joint motion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Limited ability to straighten the arm at the elbow joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Decreased elbow extension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Elbow limited extension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Limitation of elbow extension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Limited elbow extension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Limited extension at elbows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Limited forearm extension" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "N,N,N-trimethylamine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001377 ; owl:annotatedTarget "Restricted elbow extension" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001382 ; owl:annotatedTarget "The ability of a joint to move beyond its normal range of motion." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001382 ; owl:annotatedTarget "Double-Jointed" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "N,N-Dimethylmethanamine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001382 ; owl:annotatedTarget "Flexible joints" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001382 ; owl:annotatedTarget "Increased mobility of joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001384 ; owl:annotatedTarget "An abnormality of the hip joint." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "NMe3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001384 ; owl:annotatedTarget "Abnormality of the hip joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001384 ; owl:annotatedTarget "Abnormality of the hip joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001385 ; owl:annotatedTarget "The presence of developmental dysplasia of the hip." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "TMA" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001385 ; owl:annotatedTarget "Abnormal formation of the hip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001386 ; owl:annotatedTarget "Joint swelling" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "Trimethylamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001387 ; owl:annotatedTarget "Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001387 ; owl:annotatedTarget "Joint stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001387 ; owl:annotatedTarget "Stiff joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001387 ; owl:annotatedTarget "Stiff joints" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18139 ; owl:annotatedTarget "tridimethylaminomethane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001388 ; owl:annotatedTarget "Lack of stability of a joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001388 ; owl:annotatedTarget "Joint instability" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001388 ; owl:annotatedTarget "Lax joints" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001388 ; owl:annotatedTarget "Loose-jointedness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001388 ; owl:annotatedTarget "Loosejointedness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001392 ; owl:annotatedTarget "An abnormality of the liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001392 ; owl:annotatedTarget "Abnormal liver" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001392 ; owl:annotatedTarget "Abnormality of the liver" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001392 ; owl:annotatedTarget "Liver abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001392 ; owl:annotatedTarget "Liver disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001394 ; owl:annotatedTarget "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001394 ; owl:annotatedTarget "Scar tissue replaces healthy tissue in the liver" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001394 ; owl:annotatedTarget "Liver cirrhosis" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18140 ; owl:annotatedTarget "hydrogen halide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001395 ; owl:annotatedTarget "The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001396 ; owl:annotatedTarget "Impairment of bile flow due to obstruction in bile ducts." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001396 ; owl:annotatedTarget "Slowed or blocked flow of bile from liver" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18140 ; owl:annotatedTarget "hydrogen halides" . [] oboInOwl:hasDbXref , "PMID:31603713" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001397 ; owl:annotatedTarget "Steatosis is a term used to denote lipid accumulation within hepatocytes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001397 ; owl:annotatedTarget "Fatty infiltration of liver" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001397 ; owl:annotatedTarget "Fatty liver" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18140 ; owl:annotatedTarget "HX" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001399 ; owl:annotatedTarget "Liver failure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001402 ; owl:annotatedTarget "A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001403 ; owl:annotatedTarget "A form of hepatic steatosis characterized by the presence of large, lipid-laden vesicles in the affected hepatocytes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001404 ; owl:annotatedTarget "Death of liver cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18140 ; owl:annotatedTarget "hydrogen halides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001405 ; owl:annotatedTarget "The presence of fibrosis affecting the interlobular stroma of liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001406 ; owl:annotatedTarget "Impairment of bile flow due to obstruction in the small bile ducts within the liver." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001406 ; owl:annotatedTarget "Impaired release of bile from liver" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "Polysaccharide" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001407 ; owl:annotatedTarget "Liver cysts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001408 ; owl:annotatedTarget "Proliferative changes of the bile ducts." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "polysaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001409 ; owl:annotatedTarget "Increased pressure in the portal vein." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_133608 ; owl:annotatedTarget "2-azaniumyl-3-(1-methyl-1H-imidazol-4-yl)propanoate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "Glycan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001410 ; owl:annotatedTarget "Reduced ability of the liver to perform its functions." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001410 ; owl:annotatedTarget "Decreased liver function" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001410 ; owl:annotatedTarget "Liver dysfunction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001410 ; owl:annotatedTarget "Liver dysfunction, mild" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "Glycane" . [] oboInOwl:hasDbXref "PMID:15056237" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001412 ; owl:annotatedTarget "Inflammation of the liver due to infection with enterovirus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001413 ; owl:annotatedTarget "A type of cirrhosis characterized by the presence of small regenerative nodules." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001414 ; owl:annotatedTarget "A form of hepatic steatosis characterized by the presence of small, lipid-laden vesicles in the affected hepatocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001417 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001417 ; owl:annotatedTarget "X-linked form" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001419 ; owl:annotatedTarget "A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001419 ; owl:annotatedTarget "X-linked recessive" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "Glykan" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001421 ; owl:annotatedTarget "Abnormal hand muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001423 ; owl:annotatedTarget "A mode of inheritance that is observed for dominant traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked dominant disorders tend to manifest very severely in affected males. The severity of manifestation in females may depend on the degree of skewed X inactivation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001423 ; owl:annotatedTarget "X-linked dominant" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001426 ; owl:annotatedTarget "A mode of inheritance that depends on genetic determinants in more than one gene." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "Glykane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001427 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy)." . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001427 ; owl:annotatedTarget "mitochondrial" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "glycans" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001430 ; owl:annotatedTarget "Abnormal calf muscles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "polisacarido" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18154 ; owl:annotatedTarget "polisacaridos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001433 ; owl:annotatedTarget "Simultaneous enlargement of the liver and spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001433 ; owl:annotatedTarget "Enlarged liver and spleen" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001435 ; owl:annotatedTarget "Abnormality of shoulder musculature" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001436 ; owl:annotatedTarget "An anomaly of the musculature of foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001436 ; owl:annotatedTarget "Abnormal foot muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001438 ; owl:annotatedTarget "A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001438 ; owl:annotatedTarget "Abnormality of abdomen structure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001438 ; owl:annotatedTarget "Abdomen abnormality" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Beilstein:5251861" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001440 ; owl:annotatedTarget "Fusion of the long bones of the feet" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Beilstein:82132" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001441 ; owl:annotatedTarget "Abnormal thigh muscles" . [] oboInOwl:hasDbXref , "PMID:12360233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001442 ; owl:annotatedTarget "Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "CAS:98-79-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001443 ; owl:annotatedTarget "Abnormality of glutes" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "CAS:98-79-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001446 ; owl:annotatedTarget "Abnormal upper limb muscles" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "CAS:98-79-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001449 ; owl:annotatedTarget "Duplication of long bones of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001450 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001450 ; owl:annotatedTarget "monoallelic_Y_hemizygous" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Gmelin:1125330" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "PMID:22560249" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001459 ; owl:annotatedTarget "Syndactyly with fusion of toes one to three." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001459 ; owl:annotatedTarget "Webbed 1st-3rd toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "PMID:22619187" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001460 ; owl:annotatedTarget "Absence or underdevelopment of the musculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001460 ; owl:annotatedTarget "Absent/small skeletal muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001460 ; owl:annotatedTarget "Absent/underdeveloped skeletal muscles" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Reaxys:82132" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001464 ; owl:annotatedTarget "Absence or underdevelopment of the muscles of the shoulder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001464 ; owl:annotatedTarget "Absent/small shoulder muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001464 ; owl:annotatedTarget "Absent/underdeveloped shoulder muscles" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "(2S)-5-oxopyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001465 ; owl:annotatedTarget "Shoulder muscle degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001465 ; owl:annotatedTarget "Wasting of shoulder muscles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "5-Oxo-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001467 ; owl:annotatedTarget "Absence or underdevelopment of the musculature of the upper limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001467 ; owl:annotatedTarget "Absent/small upper limb muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001467 ; owl:annotatedTarget "Absent/underdeveloped upper limb muscles" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "5-oxo-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001468 ; owl:annotatedTarget "Absence or underdevelopment of the muscles of the upper arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001468 ; owl:annotatedTarget "Absent/small upper arm muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001468 ; owl:annotatedTarget "Absent/underdeveloped upper arm muscles" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "(-)-2-pyrrolidone-5-carboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001471 ; owl:annotatedTarget "Absent/small pelvis muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001471 ; owl:annotatedTarget "Absent/underdeveloped pelvis muscles" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "(S)-(-)-2-pyrrolidone-5-carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001473 ; owl:annotatedTarget "Osteolysis involving metatarsal bones." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "(S)-pyroglutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001474 ; owl:annotatedTarget "Increased density of the bony tissue of the scapula." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "5-Pyrrolidone-2-carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "A delay in closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Delayed closure of the soft spot on the skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Late closure of soft spot on the skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Delayed closure of the bregma sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Late closure of anterior fontanelle" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "L-5-Pyrrolidone-2-carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Late closure of the bregma sutures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001476 ; owl:annotatedTarget "Later than typical closing of soft spot of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001477 ; owl:annotatedTarget "A tendency to hold the chin elevated by about 20 to 30 degrees to compensate for a limitation of eye movement." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001480 ; owl:annotatedTarget "Freckling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001482 ; owl:annotatedTarget "Slightly elevated lesions on or in the skin with a diameter of over 5 mm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001482 ; owl:annotatedTarget "Nodule below the skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001482 ; owl:annotatedTarget "Firm lump under the skin" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001482 ; owl:annotatedTarget "Growth of abnormal tissue under the skin" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001482 ; owl:annotatedTarget "Subcutaneous nodules" . [] oboInOwl:hasDbXref "PMID:8157154" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001483 ; owl:annotatedTarget "Repetitive pressing, poking, and/or rubbing in the eyes." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "L-Pyroglutamic acid" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001483 ; owl:annotatedTarget "Blindism" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001483 ; owl:annotatedTarget "Eye pressing" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001483 ; owl:annotatedTarget "Ocular auto-stimulation" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001483 ; owl:annotatedTarget "Oculodigital phenomenon" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001488 ; owl:annotatedTarget "Drooping of both upper eyelids" . [] oboInOwl:hasDbXref , "PMID:24376338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001489 ; owl:annotatedTarget "Separation of the vitreous humor from the retina." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "PYROGLUTAMIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001491 ; owl:annotatedTarget "Congenital non-progressive ophthalmoplegia with multiple extraocular muscle restrictions. Typically, there is ptosis and variable degrees of restriction of horizontal and vertical eye movements." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001491 ; owl:annotatedTarget "CFEOM" . [] oboInOwl:hasDbXref , , "http://www.omim.org/entry/135700" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001491 ; owl:annotatedTarget "Congenital ophthalmoplegia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001492 ; owl:annotatedTarget "Axenfeld's anomaly is a bilateral disorder characterized by a prominent, anteriorly displaced Schwalbe's line (posterior embryotoxon) and peripheral iris strands which span the anterior chamber angle to attach to Schwalbe's line." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001493 ; owl:annotatedTarget "An area of the retina that is buckled so that a sector-shaped sheet of retina lies in front of the normal retina. This feature is of congenital onset." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_133609 ; owl:annotatedTarget "2-azaniumyl-3-(1-methyl-1H-imidazol-5-yl)propanoate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Pyroglutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001495 ; owl:annotatedTarget "Osteolysis affecting carpal bones." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "Pyroglutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001498 ; owl:annotatedTarget "Underdevelopment of one or more carpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001498 ; owl:annotatedTarget "Small wrist bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001498 ; owl:annotatedTarget "Small carpal bones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18183 ; owl:annotatedTarget "pidolic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001498 ; owl:annotatedTarget "Small carpals" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001500 ; owl:annotatedTarget "Increased width of a non-thumb digit of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001500 ; owl:annotatedTarget "Broad finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001500 ; owl:annotatedTarget "Broad fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001500 ; owl:annotatedTarget "Wide fingers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001501 ; owl:annotatedTarget "6 long bones of hand" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001507 ; owl:annotatedTarget "Abnormal growth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001507 ; owl:annotatedTarget "Growth abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001507 ; owl:annotatedTarget "Growth issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001508 ; owl:annotatedTarget "Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001508 ; owl:annotatedTarget "Undergrowth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001508 ; owl:annotatedTarget "Faltering weight" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001508 ; owl:annotatedTarget "Weight faltering" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001508 ; owl:annotatedTarget "Poor weight gain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "A deficiency or slowing down of growth pre- and postnatally." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Delayed growth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Growth deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Growth delay" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Growth failure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Growth retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Poor growth" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Beilstein:515881" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Retarded growth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001510 ; owl:annotatedTarget "Very poor growth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001511 ; owl:annotatedTarget "An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "CAS:55520-40-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001511 ; owl:annotatedTarget "IUGR" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001511 ; owl:annotatedTarget "Prenatal growth deficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001511 ; owl:annotatedTarget "Prenatal growth retardation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "CAS:556-03-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001513 ; owl:annotatedTarget "Having too much body fat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001513 ; owl:annotatedTarget "Obesity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001518 ; owl:annotatedTarget "Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001518 ; owl:annotatedTarget "Birth weight less than 10th percentile" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001518 ; owl:annotatedTarget "Low birth weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001518 ; owl:annotatedTarget "Small for gestational age" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001519 ; owl:annotatedTarget "A tall and slim body build with increased arm span to height ratio (>1.05) and a reduced upper-to-lower segment ratio (<0.85), i.e., unusually long arms and legs. The extremities as well as the hands and feet are unusually slim." . [] oboInOwl:hasDbXref , "eMedicine:262679" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001520 ; owl:annotatedTarget "The term large for gestational age applies to babies whose birth weight lies above the 90th percentile for that gestational age." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Gmelin:27744" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001520 ; owl:annotatedTarget "Birth weight > 90th percentile" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001520 ; owl:annotatedTarget "Birthweight > 90th percentile" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001520 ; owl:annotatedTarget "Foetal macrosomia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001520 ; owl:annotatedTarget "Macrosomia, neonatal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001522 ; owl:annotatedTarget "Death within the first 24 months of life." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001522 ; owl:annotatedTarget "Death in infancy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001522 ; owl:annotatedTarget "Infantile death" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001522 ; owl:annotatedTarget "Lethal in infancy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001522 ; owl:annotatedTarget "Death in early childhood" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001525 ; owl:annotatedTarget "Severe faltering weight" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001525 ; owl:annotatedTarget "Severe weight faltering" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Reaxys:515881" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001528 ; owl:annotatedTarget "Overgrowth of only one side of the body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001528 ; owl:annotatedTarget "Asymmetric overgrowth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001530 ; owl:annotatedTarget "A mild degree of slow or limited growth after birth, being between two and three standard deviations below age- and sex-related norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001530 ; owl:annotatedTarget "Mild growth deficiency" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001531 ; owl:annotatedTarget "Faltering weight in infancy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001531 ; owl:annotatedTarget "Weight faltering in infancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001533 ; owl:annotatedTarget "Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001533 ; owl:annotatedTarget "Slender build" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001533 ; owl:annotatedTarget "Thin build" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Tyrosine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001537 ; owl:annotatedTarget "Protrusion of abdominal contents through a defect in the abdominal wall musculature around the umbilicus. Skin and subcutaneous tissue overlie the defect." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "tyrosine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001538 ; owl:annotatedTarget "A thrusting or bulging out of the abdomen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001538 ; owl:annotatedTarget "Belly sticks out" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001538 ; owl:annotatedTarget "Extended belly" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "2-Amino-3-(p-hydroxyphenyl)propionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001539 ; owl:annotatedTarget "A midline anterior incomplete closure of the abdominal wall in which there is herniation of the abdominal viscera into the base of the abdominal cord." . [] a owl:Axiom ; rdfs:label "Omphalocoele" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001539 ; owl:annotatedTarget "MEDDRA:10030309" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "2-amino-3-(4-hydroxyphenyl)propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001540 ; owl:annotatedTarget "A separation of the rectus abdominis muscle into right and left halves (which are normally joined at the midline at the linea alba)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001540 ; owl:annotatedTarget "Gap between large left and right abdominal muscles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "3-(p-Hydroxyphenyl)alanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001541 ; owl:annotatedTarget "Accumulation of fluid in the peritoneal cavity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001541 ; owl:annotatedTarget "Accumulation of fluid in the abdomen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Tyr" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001543 ; owl:annotatedTarget "A type of congenital ventral incomplete closure of the abdominal wall in which the intestines and sometimes other organs extend freely into the amniotic fluid space through a small opening in the abdomen, usually to the right of the umbilicus." . [] a owl:Axiom ; rdfs:label "Gastroschisis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001543 ; owl:annotatedTarget "MEDDRA:10018046" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001544 ; owl:annotatedTarget "Abnormally prominent umbilicus (belly button)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Tyrosin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001544 ; owl:annotatedTarget "Prominent belly button" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001544 ; owl:annotatedTarget "Prominent navel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001545 ; owl:annotatedTarget "Anterior malposition of the anus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "Y" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001547 ; owl:annotatedTarget "A morphological anomaly of the rib cage." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001547 ; owl:annotatedTarget "Abnormality of the rib cage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18186 ; owl:annotatedTarget "tirosina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001548 ; owl:annotatedTarget "Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001548 ; owl:annotatedTarget "General overgrowth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001548 ; owl:annotatedTarget "Generalised overgrowth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001548 ; owl:annotatedTarget "Generalized overgrowth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001551 ; owl:annotatedTarget "An abnormality of the structure or appearance of the umbilicus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001551 ; owl:annotatedTarget "Abnormal belly button" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001551 ; owl:annotatedTarget "Abnormal navel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001552 ; owl:annotatedTarget "A rounded, bulging chest that resembles the shape of a barrel. That is, there is an increased anteroposterior diameter and usually some degree of kyphosis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001552 ; owl:annotatedTarget "Barrel chest" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001552 ; owl:annotatedTarget "Barrel-shaped chest" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Beilstein:1725417" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001555 ; owl:annotatedTarget "Lack of symmetry between the left and right halves of the thorax." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001555 ; owl:annotatedTarget "Asymmetric chest" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001557 ; owl:annotatedTarget "An abnormality of fetal movement." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "An abnormal reduction in quantity or strength of fetal movements." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Beilstein:2328251" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Decreased foetal activity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Decreased foetal movement" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Decreased foetal movements" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Dminished foetal movement" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Foetal hypokinesia" . [] oboInOwl:hasDbXref "PMID:2729383" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Less than 10 fetal movements in 12 hours" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Less than 10 foetal movements in 12 hours" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Reduced foetal movement" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001558 ; owl:annotatedTarget "Reduced foetal movements" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "CAS:627-77-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001560 ; owl:annotatedTarget "Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "CAS:627-77-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001561 ; owl:annotatedTarget "The presence of excess amniotic fluid in the uterus during pregnancy." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001561 ; owl:annotatedTarget "High levels of amniotic fluid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_133610 ; owl:annotatedTarget "(2-methylpropanamido)acetate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:11094453" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001562 ; owl:annotatedTarget "Diminished amniotic fluid volume in pregnancy." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001562 ; owl:annotatedTarget "Low levels of amniotic fluid" . [] oboInOwl:hasDbXref , "PMID:21460147" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001563 ; owl:annotatedTarget "Abnormally increased production of urine by the fetus resulting in polyhydramnios." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001563 ; owl:annotatedTarget "Foetal polyuria" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:11113071" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Increased distance between the maxillary central permanent incisor tooth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Central incisor gap" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Gap between upper front teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Wide gap between upper central incisors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Widely spaced upper incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Diastema between maxillary central incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Diastema between upper front teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001566 ; owl:annotatedTarget "Diastema between upper incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001571 ; owl:annotatedTarget "The presence of multiple impacted teeth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:11696417" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001571 ; owl:annotatedTarget "Multiple buried teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001571 ; owl:annotatedTarget "Multiple retained teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001571 ; owl:annotatedTarget "Impacted teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001571 ; owl:annotatedTarget "Multiple impacted teeth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:1378088" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Increased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD above mean for age. Alternatively, an apparently increased maximum width of the tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Hyperplasia of tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Hypertrophy of tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Increased size of tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Increased width of tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Large tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001572 ; owl:annotatedTarget "Tooth mass excess" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:16082501" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001574 ; owl:annotatedTarget "An abnormality of the integument, which consists of the skin and the superficial fascia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001579 ; owl:annotatedTarget "Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001581 ; owl:annotatedTarget "Infections of the skin that happen multiple times." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001581 ; owl:annotatedTarget "Recurrent skin infections" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001581 ; owl:annotatedTarget "Skin infections, recurrent" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:16708633" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001582 ; owl:annotatedTarget "Loose and sagging skin often associated with loss of skin elasticity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001582 ; owl:annotatedTarget "Loose redundant skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001582 ; owl:annotatedTarget "Redundant skin folds" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001582 ; owl:annotatedTarget "Sagging, redundant skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001583 ; owl:annotatedTarget "A form of nystagmus in which the eyeball makes rotary motions around the axis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001586 ; owl:annotatedTarget "The presence of a fistula connecting the urinary bladder to the vagina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001591 ; owl:annotatedTarget "The rib cage has the shape of a wide mouthed bell. That is, the superior portion of the rib cage is constricted, followed by a convex region, and the inferior portion of the rib cage expands again to have a large diameter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001592 ; owl:annotatedTarget "Agenesis specifically affecting one of the classes incisor, premolar, or molar." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001592 ; owl:annotatedTarget "Agenesis of a tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001592 ; owl:annotatedTarget "Failure of development of a tooth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:17005970" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001592 ; owl:annotatedTarget "Absence of a tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001592 ; owl:annotatedTarget "Missing a tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Decreased size of the maxillary permanent incisor." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:17513438" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Decreased size of maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Decreased size of upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Hypotrophic maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Hypotrophic upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Small maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Small upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001593 ; owl:annotatedTarget "Decreased width of upper lateral incisor" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:17558653" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001595 ; owl:annotatedTarget "An abnormality of the hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001595 ; owl:annotatedTarget "Abnormality of the hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001595 ; owl:annotatedTarget "Hair abnormality" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001595 ; owl:annotatedTarget "Abnormality of the hair shaft" . [] oboInOwl:hasDbXref "PMID:14676077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001596 ; owl:annotatedTarget "A noncongenital process of hair loss, which may progress to partial or complete baldness." . [] a owl:Axiom ; rdfs:label "Alopecia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001596 ; owl:annotatedTarget "MEDDRA:10001760" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:17693747" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001596 ; owl:annotatedTarget "Hair loss" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001597 ; owl:annotatedTarget "Abnormality of the nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001597 ; owl:annotatedTarget "Abnormality of the nail" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133610 ; owl:annotatedTarget "N-(2-methylpropanoyl)glycinate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:18437289" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001597 ; owl:annotatedTarget "Nail disease" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001598 ; owl:annotatedTarget "The natural longitudinal (posterodistal) convex arch is not present or is inverted." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001598 ; owl:annotatedTarget "Spoon-shaped nails" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:18440672" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001600 ; owl:annotatedTarget "An abnormality of the larynx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001601 ; owl:annotatedTarget "Laryngomalacia is a congenital abnormality of the laryngeal cartilage in which the cartilage is floppy and prolapses over the larynx during inspiration." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001601 ; owl:annotatedTarget "Softening of voice box tissue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:18989563" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001602 ; owl:annotatedTarget "Stricture or narrowing of the larynx that may be associated with symptoms of respiratory difficulty depending on the degree of laryngeal narrowing." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001604 ; owl:annotatedTarget "Decreased strength of the vocal folds." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001604 ; owl:annotatedTarget "Weakness of the vocal cords" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:19144577" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001605 ; owl:annotatedTarget "A loss of the ability to move the vocal folds." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001605 ; owl:annotatedTarget "Inability to move vocal cords" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:21129371" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001608 ; owl:annotatedTarget "Abnormality of the voice" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001608 ; owl:annotatedTarget "Voice abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001609 ; owl:annotatedTarget "Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001609 ; owl:annotatedTarget "Hoarse voice" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "PMID:21482070" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001609 ; owl:annotatedTarget "Hoarseness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001609 ; owl:annotatedTarget "Husky voice" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001611 ; owl:annotatedTarget "Hypernasal voice" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001611 ; owl:annotatedTarget "Nasal speech" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001611 ; owl:annotatedTarget "Nasal voice" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001615 ; owl:annotatedTarget "Hoarse cry" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001618 ; owl:annotatedTarget "Inability to produce voice sounds" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001618 ; owl:annotatedTarget "Voice change" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001620 ; owl:annotatedTarget "High pitched voice" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001620 ; owl:annotatedTarget "High-pitched voice" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Reaxys:1725417" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001621 ; owl:annotatedTarget "Reduced intensity (volume) of speech." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001621 ; owl:annotatedTarget "Soft voice" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001621 ; owl:annotatedTarget "Weak voice" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "2-amino-5-(carbamoylamino)pentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001622 ; owl:annotatedTarget "The birth of a baby of less than 37 weeks of gestational age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001622 ; owl:annotatedTarget "Premature birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001622 ; owl:annotatedTarget "Premature delivery of affected infants" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001622 ; owl:annotatedTarget "Preterm delivery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001623 ; owl:annotatedTarget "A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001623 ; owl:annotatedTarget "Feet or buttocks of fetus positioned near opening of uterus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001623 ; owl:annotatedTarget "Feet or buttocks of foetus positioned near opening of uterus" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Citrulline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001626 ; owl:annotatedTarget "Any abnormality of the cardiovascular system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001626 ; owl:annotatedTarget "Abnormality of the cardiovascular system" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001626 ; owl:annotatedTarget "Cardiovascular abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001626 ; owl:annotatedTarget "Cardiovascular disease" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "N(5)-carbamoylornithine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001627 ; owl:annotatedTarget "Any structural anomaly of the heart." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001627 ; owl:annotatedTarget "Abnormality of the heart" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001627 ; owl:annotatedTarget "Abnormally shaped heart" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001627 ; owl:annotatedTarget "Heart defect" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133610 ; owl:annotatedTarget "N-isobutanoylglycinate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "citrulline" . [] oboInOwl:hasDbXref , "PMID:33327983" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001629 ; owl:annotatedTarget "A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001629 ; owl:annotatedTarget "Hole in heart wall separating two lower heart chambers" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001629 ; owl:annotatedTarget "VSD" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "2-Amino-5-uredovaleric acid" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001631 ; owl:annotatedTarget "Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001631 ; owl:annotatedTarget "ASD" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001631 ; owl:annotatedTarget "An opening in the wall separating the top two chambers of the heart" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001631 ; owl:annotatedTarget "Hole in heart wall separating two upper heart chambers" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Cit" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001633 ; owl:annotatedTarget "Any structural anomaly of the mitral valve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "Citrullin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001634 ; owl:annotatedTarget "One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "DL-2-amino-5-ureidovaleric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001635 ; owl:annotatedTarget "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001635 ; owl:annotatedTarget "CHF" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001635 ; owl:annotatedTarget "Cardiac failure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001635 ; owl:annotatedTarget "Cardiac failures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001635 ; owl:annotatedTarget "Heart failure" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "N(5)-(aminocarbonyl)-DL-ornithine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "N(5)-(aminocarbonyl)ornithine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001636 ; owl:annotatedTarget "A congenital cardiac malformation comprising pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy. The diagnosis of TOF is made if at least three of the four above mentioned features are present." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "N(5)-carbamoyl-DL-ornithine" . [] oboInOwl:hasDbXref , "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001638 ; owl:annotatedTarget "A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001638 ; owl:annotatedTarget "Disease of the heart muscle" . [] oboInOwl:hasDbXref "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001639 ; owl:annotatedTarget "Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001639 ; owl:annotatedTarget "Enlarged and thickened heart muscle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "citrulina" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001639 ; owl:annotatedTarget "HCM" . [] oboInOwl:hasDbXref , "PMID:31194436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001640 ; owl:annotatedTarget "Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001640 ; owl:annotatedTarget "Enlarged heart" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18211 ; owl:annotatedTarget "dl-citrulline" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001640 ; owl:annotatedTarget "Increased heart size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001641 ; owl:annotatedTarget "Any structural abnormality of the pulmonary valve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133610 ; owl:annotatedTarget "isobutanoylglycinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001642 ; owl:annotatedTarget "A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001642 ; owl:annotatedTarget "Narrowing of pulmonic valve" . [] oboInOwl:hasDbXref , "PMID:20421261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001643 ; owl:annotatedTarget "In utero, the ductus arteriosus (DA) serves to divert ventricular output away from the lungs and toward the placenta by connecting the main pulmonary artery to the descending aorta. A patent ductus arteriosus (PDA) in the first 3 days of life is a physiologic shunt in healthy term and preterm newborn infants, and normally is substantially closed within about 24 hours after bith and completely closed after about three weeks. Failure of physiologcal closure is referred to a persistent or patent ductus arteriosus (PDA). Depending on the degree of left-to-right shunting, PDA can have clinical consequences." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001643 ; owl:annotatedTarget "PDA" . [] oboInOwl:hasDbXref "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001644 ; owl:annotatedTarget "Dilated cardiomyopathy (DCM) is defined by the presence of left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary artery disease sufficient to cause global systolic impairment. Right ventricular dilation and dysfunction may be present but are not necessary for the diagnosis." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001644 ; owl:annotatedTarget "DCM" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001644 ; owl:annotatedTarget "Stretched and thinned heart muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001645 ; owl:annotatedTarget "The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001645 ; owl:annotatedTarget "Premature sudden cardiac death" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001645 ; owl:annotatedTarget "Sudden cardiac death" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Beilstein:1723799" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001646 ; owl:annotatedTarget "Any abnormality of the aortic valve." . [] oboInOwl:hasDbXref , "PMID:17467434", "PMID:24827036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001647 ; owl:annotatedTarget "The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001647 ; owl:annotatedTarget "Aortic valve has two leaflets rather than three" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "CAS:617-65-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001648 ; owl:annotatedTarget "Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "A rapid heartrate that exceeds the range of the normal resting heartrate for age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Fast heart rate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Heart racing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Racing heart" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Elevated heart rate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Increased heart rate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001649 ; owl:annotatedTarget "Rapid heart beat" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "CAS:617-65-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001650 ; owl:annotatedTarget "The presence of a stenosis (narrowing) of the aortic valve." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001650 ; owl:annotatedTarget "Narrowing of aortic valve" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "CAS:617-65-2" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001651 ; owl:annotatedTarget "The heart is located in the right hand sided hemithorax. That is, there is a left-right reversal (or \"mirror reflection\") of the anatomical location of the heart in which the heart is locate on the right side instead of the left." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001651 ; owl:annotatedTarget "Heart tip and four chambers point towards right side of body" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Gmelin:101971" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001653 ; owl:annotatedTarget "An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "PMID:15739367" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001654 ; owl:annotatedTarget "Any structural abnormality of a cardiac valve." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001655 ; owl:annotatedTarget "Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001657 ; owl:annotatedTarget "Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001658 ; owl:annotatedTarget "Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001658 ; owl:annotatedTarget "Heart attack" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001658 ; owl:annotatedTarget "MI" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133610 ; owl:annotatedTarget "isobutyrylglycinate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "PMID:24616376" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001659 ; owl:annotatedTarget "An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001660 ; owl:annotatedTarget "A single arterial trunk arises from the cardiac mass. The pulmonary arteries, aorta and coronary arteries arise from this single trunk with no evidence of another outflow tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001662 ; owl:annotatedTarget "A slower than normal heart rate (in adults, slower than 60 beats per minute)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "PMID:24984001" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001662 ; owl:annotatedTarget "Slow heartbeats" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Reaxys:1723799" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001663 ; owl:annotatedTarget "Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001664 ; owl:annotatedTarget "A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001667 ; owl:annotatedTarget "In this case the right ventricle is more muscular than normal, causing a characteristic boot-shaped (coeur-en-sabot) appearance as seen on anterior- posterior chest x-rays. Right ventricular hypertrophy is commonly associated with any form of right ventricular outflow obstruction or pulmonary hypertension, which may in turn owe its origin to left-sided disease. The echocardiographic signs are thickening of the anterior right ventricular wall and the septum. Cavity size is usually normal, or slightly enlarged. In many cases there is associated volume overload present due to tricuspid regurgitation, in the absence of this, septal motion is normal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "2-aminopentanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001667 ; owl:annotatedTarget "Heart right ventricle hypertrophy" . [] oboInOwl:hasDbXref , "PMID:10798431", "eMedicine:900574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001669 ; owl:annotatedTarget "A complex congenital heart defect in which the aorta arises from the morphologic right ventricle and the pulmonary artery arises from the morphologic left ventricle." . [] oboInOwl:hasDbXref , "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001670 ; owl:annotatedTarget "Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Glutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001671 ; owl:annotatedTarget "An anomaly of the intra-atrial or intraventricular septum." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001671 ; owl:annotatedTarget "Septal defects" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:16722604" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001674 ; owl:annotatedTarget "A congenital heart defect characterized by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect." . [] oboInOwl:hasDbXref , "PMID:31420554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001677 ; owl:annotatedTarget "Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001677 ; owl:annotatedTarget "Plaque build-up in arteries supplying blood to heart" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001678 ; owl:annotatedTarget "Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001678 ; owl:annotatedTarget "Interruption of electrical communication between upper and lower chambers of heart" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "glutamic acid" . [] oboInOwl:hasDbXref , "PMID:24910511" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001679 ; owl:annotatedTarget "An abnormality of the aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001679 ; owl:annotatedTarget "Abnormal aorta morphology" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "2-Aminoglutaric acid" . [] oboInOwl:hasDbXref , "PMID:23909637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001680 ; owl:annotatedTarget "Coarctation of the aorta is a narrowing or constriction of a segment of the aorta." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001680 ; owl:annotatedTarget "Narrowing of aorta" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001680 ; owl:annotatedTarget "Narrowing of the aorta" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001681 ; owl:annotatedTarget "Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001682 ; owl:annotatedTarget "A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001682 ; owl:annotatedTarget "Narrowing of blood vessel below aortic heart valve" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001683 ; owl:annotatedTarget "Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and through the defect in the ventral wall." . [] oboInOwl:hasDbXref "KEGG_DRUG" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "DL-Glutamic acid" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001684 ; owl:annotatedTarget "A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001684 ; owl:annotatedTarget "Atrial septal defect, ostium secundum type" . [] oboInOwl:hasDbXref "PMID:28157267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001685 ; owl:annotatedTarget "Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "DL-Glutaminic acid" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001686 ; owl:annotatedTarget "Aphonia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001688 ; owl:annotatedTarget "Bradycardia related to a mean resting sinus rate of less than 50 beats per minute." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001691 ; owl:annotatedTarget "A type of subvalvular aortic stenosis resulting from thickening of the musculature of the interventricular septum, which results in obstruction to blood flow through the left-ventricular outflow tract." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001692 ; owl:annotatedTarget "A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001693 ; owl:annotatedTarget "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001694 ; owl:annotatedTarget "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the right side of the heart to the left." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001695 ; owl:annotatedTarget "Heart stops beating" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001696 ; owl:annotatedTarget "A left-right reversal (or \"mirror reflection\") of the anatomical location of the major thoracic and abdominal organs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001696 ; owl:annotatedTarget "All organs on wrong side of body" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "E" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001697 ; owl:annotatedTarget "An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001698 ; owl:annotatedTarget "Accumulation of fluid within the pericardium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001698 ; owl:annotatedTarget "Fluid around heart" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001699 ; owl:annotatedTarget "Rapid and unexpected death." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Glu" . [] oboInOwl:hasDbXref "PMID:20405318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001700 ; owl:annotatedTarget "Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001701 ; owl:annotatedTarget "Inflammation of the sac-like covering around the heart (pericardium)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Glutaminic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001701 ; owl:annotatedTarget "Swelling or irritation of membrane around heart" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001702 ; owl:annotatedTarget "Any structural anomaly of the tricuspid valve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18237 ; owl:annotatedTarget "Glutaminsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001704 ; owl:annotatedTarget "One or more of the leaflets (cusps) of the tricuspid valve bulges back into the right atrium upon contraction of the right ventricle." . [] oboInOwl:hasDbXref "PMID:30038501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001705 ; owl:annotatedTarget "An obstruction to the forward flow of blood in the outflow tract of the right ventricle." . [] oboInOwl:hasDbXref "PMID:23109776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001706 ; owl:annotatedTarget "Diffuse thickening of the ventricular endocardium and by associated myocardial dysfunction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001707 ; owl:annotatedTarget "An abnormality of the right ventricle of the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001708 ; owl:annotatedTarget "Reduced ability of the right ventricle to perform its function (to receive blood from the right atrium and to eject blood into the pulmonary artery), often leading to pitting peripheral edema, ascites, and hepatomegaly." . [] oboInOwl:hasDbXref "PMID:21841933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001709 ; owl:annotatedTarget "Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001709 ; owl:annotatedTarget "Complete heart block" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001710 ; owl:annotatedTarget "A congenital malformation of the outflow tract of the heart. Conotruncal defects are thought to result from a disturbance of the outflow tract of the embryonic heart, and comprise truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, transposition of the great arteries, and double outlet right ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001711 ; owl:annotatedTarget "Any structural abnormality of the left ventricle of the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001711 ; owl:annotatedTarget "Abnormal heart left ventricle morphology" . [] oboInOwl:hasDbXref "MP:0002625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001712 ; owl:annotatedTarget "Enlargement or increased size of the heart left ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001712 ; owl:annotatedTarget "Heart left ventricle hypertrophy" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "CAS:51-35-4" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "Reaxys:81441" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001713 ; owl:annotatedTarget "An abnormality of a cardiac ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001714 ; owl:annotatedTarget "Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001716 ; owl:annotatedTarget "A disorder of the cardiac conduction system of the heart characterized by ventricular preexcitation due to the presence of an abnormal accessory atrioventricular electrical conduction pathway." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "4-Hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001717 ; owl:annotatedTarget "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a coronary artery." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "4-hydroxy-L-proline" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001718 ; owl:annotatedTarget "An abnormal narrowing of the orifice of the mitral valve." . [] oboInOwl:hasDbXref , "PMID:10798433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001719 ; owl:annotatedTarget "Double outlet right ventricle (DORV) is a type of ventriculoarterial connection in which both great vessels arise entirely or predominantly from the right ventricle." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001719 ; owl:annotatedTarget "DORV" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001722 ; owl:annotatedTarget "A form of heart failure characterized by elevated cardiac output. This may be seen in patients with heart failure and hyperthyroidism, anemia, pregnancy, arteriovenous fistulae, and others." . [] oboInOwl:hasDbXref , "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001723 ; owl:annotatedTarget "Restrictive left ventricular physiology is characterized by a pattern of ventricular filling in which increased stiffness of the myocardium causes ventricular pressure to rise precipitously with only small increases in volume, defined as restrictive ventricular physiology in the presence of normal or reduced diastolic volumes (of one or both ventricles), normal or reduced systolic volumes, and normal ventricular wall thickness." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "(2S)-4-hydroxypyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001727 ; owl:annotatedTarget "A cerebrovascular accident (stroke) that occurs because of thromboembolism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001730 ; owl:annotatedTarget "A progressive form of hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001732 ; owl:annotatedTarget "An abnormality of the pancreas." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "L-Hydroxyproline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001732 ; owl:annotatedTarget "Abnormality of the pancreas" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001732 ; owl:annotatedTarget "Pancreatic disease" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "cis-4-Hydroxy-L-Proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001733 ; owl:annotatedTarget "The presence of inflammation in the pancreas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001733 ; owl:annotatedTarget "Pancreatic inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001734 ; owl:annotatedTarget "A congenital anomaly in which the pancreas completely (or sometimes incompletely) encircles the second portion of duodenum and occasionally obstructs the more proximal duodenum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18240 ; owl:annotatedTarget "hydroxy-L-proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001735 ; owl:annotatedTarget "A acute form of pancreatitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001735 ; owl:annotatedTarget "Acute pancreatic inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001737 ; owl:annotatedTarget "A cyst of the pancreas that possess a lining of mucous epithelium." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001737 ; owl:annotatedTarget "Pancreatic cysts" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001737 ; owl:annotatedTarget "Multiple pancreatic cysts" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001737 ; owl:annotatedTarget "Pancreatic cyst" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001738 ; owl:annotatedTarget "Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001738 ; owl:annotatedTarget "Inability to properly digest food due to lack of pancreatic digestive enzymes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001741 ; owl:annotatedTarget "The male foreskin cannot be fully retracted from the head of the penis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Reduced ability to pass air through the nasal cavity often leading to mouth breathing." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Blockage of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Nasal blockage" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Nasal obstruction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Obstruction of nose" . [] oboInOwl:hasDbXref "http://www.entnet.org/content/stuffy-nose" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Stuffy nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0001742 ; owl:annotatedTarget "Congestion of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001743 ; owl:annotatedTarget "An abnormality of the spleen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001743 ; owl:annotatedTarget "Abnormality of the spleen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001744 ; owl:annotatedTarget "Abnormal increased size of the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001744 ; owl:annotatedTarget "Increased spleen size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001746 ; owl:annotatedTarget "Absence (aplasia) of the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001746 ; owl:annotatedTarget "Absent spleen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001747 ; owl:annotatedTarget "An accessory spleen is a round, iso-echogenic, homogenic and smooth structure and is seen as a normal variant mostly on the medial contour of the spleen, near the hilus or around the lower pole. This has no pathogenic relevance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001748 ; owl:annotatedTarget "Polysplenia is a congenital disease manifested by multiple small accessory spleens." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001748 ; owl:annotatedTarget "Multiple small spleens" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "CAS:51-61-6" . [] oboInOwl:hasDbXref "MP:0010432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001750 ; owl:annotatedTarget "The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001750 ; owl:annotatedTarget "Common ventricle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001751 ; owl:annotatedTarget "An abnormality of the functioning of the vestibular apparatus." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "Drug_Central:947" . [] oboInOwl:hasDbXref , "PMID:32767115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001756 ; owl:annotatedTarget "A general descriptive term that describes impaired functioning of the vestibular apparatus that leads to manifestations such as dizziness or postural imbalance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001757 ; owl:annotatedTarget "A form of sensorineural hearing impairment that affects primarily the higher frequencies." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "PMID:10629745" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "An abnormality of the skeleton of foot." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "Abnormal feet structure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "Abnormality of the feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "Abnormality of the foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "Foot deformities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001760 ; owl:annotatedTarget "Foot deformity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "PMID:11149432" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001761 ; owl:annotatedTarget "An increase in height of the medial longitudinal arch of the foot that does not flatten on weight bearing (i.e., a distinctly hollow form of the sole of the foot when it is bearing weight)." . [] a owl:Axiom ; rdfs:label "Pes cavus" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001761 ; owl:annotatedTarget "MEDDRA:10034743" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001761 ; owl:annotatedTarget "High-arched foot" . [] oboInOwl:hasDbXref , "PMID:32491773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Talipes equinovarus (also called clubfoot) typically has four main components: inversion and adduction of the forefoot; inversion of the heel and hindfoot; equinus (limitation of extension) of the ankle and subtalar joint; and internal rotation of the leg." . [] a owl:Axiom ; rdfs:label "Talipes equinovarus, congenital" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "MEDDRA:10043106" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Club feet" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "PMID:9422813" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Club foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Clubfeet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Clubfoot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001762 ; owl:annotatedTarget "Talipes varus" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "Reaxys:1072822" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001763 ; owl:annotatedTarget "A foot where the longitudinal arch of the foot is in contact with the ground or floor when the individual is standing; or, in a patient lying supine, a foot where the arch is in contact with the surface of a flat board pressed against the sole of the foot by the examiner with a pressure similar to that expected from weight bearing; or, the height of the arch is reduced." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001763 ; owl:annotatedTarget "Flat feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001763 ; owl:annotatedTarget "Flat foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001763 ; owl:annotatedTarget "Dropped arches" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001763 ; owl:annotatedTarget "Fallen arches" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001765 ; owl:annotatedTarget "Hyperextension of the metatarsal-phalangeal joint with hyperflexion of the proximal interphalangeal (PIP) joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001765 ; owl:annotatedTarget "Hammer toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001765 ; owl:annotatedTarget "Hammertoe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001765 ; owl:annotatedTarget "Hammertoes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-aminoethyl)benzene-1,2-diol" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001769 ; owl:annotatedTarget "A foot for which the measured width is above the 95th centile for age; or, a foot that appears disproportionately wide for its length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001769 ; owl:annotatedTarget "Broad feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001769 ; owl:annotatedTarget "Broad foot" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_133744 ; owl:annotatedTarget "(4-hydroxy-3-methoxyphenyl)acetate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "Dopamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001769 ; owl:annotatedTarget "Wide foot" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "2-(3,4-Dihydroxyphenyl)ethylamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001770 ; owl:annotatedTarget "Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\"." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001770 ; owl:annotatedTarget "Foot syndactyly" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001770 ; owl:annotatedTarget "Fused toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001770 ; owl:annotatedTarget "Webbed toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "2-(3,4-dihydroxyphenyl)ethylamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001771 ; owl:annotatedTarget "A contracture of the Achilles tendon." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001771 ; owl:annotatedTarget "Achilles tendon contractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001771 ; owl:annotatedTarget "Shortening of the achilles tendon" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001771 ; owl:annotatedTarget "Tight achilles tendon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001772 ; owl:annotatedTarget "A deformity of foot and ankle in which the foot is bent down and outwards." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "3,4-Dihydroxyphenethylamine" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001773 ; owl:annotatedTarget "A measured foot length that is more than 2 SD below the mean for a newborn of 27 - 41 weeks gestation, or foot that is less than the 3rd centile for individuals from birth to 16 years of age (objective). Alternatively, a foot that appears disproportionately short (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001773 ; owl:annotatedTarget "Short feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001773 ; owl:annotatedTarget "Short foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001773 ; owl:annotatedTarget "Small feet" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001776 ; owl:annotatedTarget "Bilateral clubfoot deformity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001776 ; owl:annotatedTarget "Club foot on both sides" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "3-Hydroxytyramine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001780 ; owl:annotatedTarget "An anomaly of a toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001780 ; owl:annotatedTarget "Abnormalities of the toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001780 ; owl:annotatedTarget "Abnormality of toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-Aminoethyl)-1,2-benzenediol" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-Aminoethyl)benzene-1,2-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001782 ; owl:annotatedTarget "An abnormality of the morphology of the toes, such that the tips of the toes are prominent and bulbous." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001783 ; owl:annotatedTarget "Increased side-to-side width of a metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001783 ; owl:annotatedTarget "Wide long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-aminoethyl)-1,2-benzenediol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001785 ; owl:annotatedTarget "Ankle swelling" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-aminoethyl)catechol" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001786 ; owl:annotatedTarget "A foot for which the measured width is below the 5th centile for age; or, a foot that appears disproportionately narrow for its length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001786 ; owl:annotatedTarget "Narrow foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001786 ; owl:annotatedTarget "Slender feet" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "4-(2-aminoethyl)pyrocatechol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001787 ; owl:annotatedTarget "An abnormality of the birth process." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001787 ; owl:annotatedTarget "Abnormal delivery" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001787 ; owl:annotatedTarget "Delivery complication" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001788 ; owl:annotatedTarget "Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133744 ; owl:annotatedTarget "3-methoxy-4-hydroxyphenylacetate" . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "Deoxyepinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001789 ; owl:annotatedTarget "The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001790 ; owl:annotatedTarget "A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens ." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001790 ; owl:annotatedTarget "Non-immune foetal hydrops" . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "Hydroxytyramin" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "dopamina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001791 ; owl:annotatedTarget "Accumulation of fluid in the peritoneal cavity during the fetal period." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001791 ; owl:annotatedTarget "Foetal ascites" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "dopamine" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001792 ; owl:annotatedTarget "A nail that is diminished in length and width, i.e., underdeveloped nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001792 ; owl:annotatedTarget "Small nail" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001792 ; owl:annotatedTarget "Small nails" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001795 ; owl:annotatedTarget "When viewed on end (with the digit tip pointing toward the examiner's eye) the curve of the nail forms a tighter curve of convexity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001795 ; owl:annotatedTarget "Increased nail curvature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001795 ; owl:annotatedTarget "Nail overcurvature" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18243 ; owl:annotatedTarget "dopaminum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001798 ; owl:annotatedTarget "Aplasia of the nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001798 ; owl:annotatedTarget "Absent nails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001798 ; owl:annotatedTarget "Aplastic nails" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001799 ; owl:annotatedTarget "Decreased length of nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001799 ; owl:annotatedTarget "Short nail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001799 ; owl:annotatedTarget "Short nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001800 ; owl:annotatedTarget "Underdevelopment of the toenail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001800 ; owl:annotatedTarget "Underdeveloped toenails" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "CAS:7439-89-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001802 ; owl:annotatedTarget "Congenital absence of the toenail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001802 ; owl:annotatedTarget "Absent toenail" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001802 ; owl:annotatedTarget "Absent toenails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001802 ; owl:annotatedTarget "Absent toenails (anonychia)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001802 ; owl:annotatedTarget "Anonychia of toenails" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "CAS:7439-89-6" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001803 ; owl:annotatedTarget "Small (typically about 1 mm or less in size) depressions on the dorsal nail surface." . [] a owl:Axiom ; rdfs:label "Nail pitting" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001803 ; owl:annotatedTarget "MEDDRA:10028702" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001803 ; owl:annotatedTarget "Nail pits" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001803 ; owl:annotatedTarget "Nail pitting" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001803 ; owl:annotatedTarget "Pitted nails" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "CAS:7439-89-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001804 ; owl:annotatedTarget "Underdevelopment of a fingernail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001804 ; owl:annotatedTarget "Small fingernail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001804 ; owl:annotatedTarget "Underdeveloped fingernail" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "Reaxys:4122945" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001805 ; owl:annotatedTarget "Nail that appears thick when viewed on end." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001805 ; owl:annotatedTarget "Thick nail" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001805 ; owl:annotatedTarget "Thickened nails" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "iron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001806 ; owl:annotatedTarget "Detachment of the nail from the nail bed." . [] a owl:Axiom ; rdfs:label "Onycholysis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001806 ; owl:annotatedTarget "MEDDRA:10030337" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001806 ; owl:annotatedTarget "Detachment of nail" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001807 ; owl:annotatedTarget "Longitudinal, linear prominences in the nail plate." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001807 ; owl:annotatedTarget "Grooved nails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001807 ; owl:annotatedTarget "Nail ridging" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "26Fe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001807 ; owl:annotatedTarget "Ridged nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001808 ; owl:annotatedTarget "Nails that easily break." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001808 ; owl:annotatedTarget "Brittle nails" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "Eisen" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001809 ; owl:annotatedTarget "A nail plate that has a longitudinal separation and the two sections of the nail share the same lateral radius of curvature." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001809 ; owl:annotatedTarget "Longitudinal splitting of nail" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "Fe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001810 ; owl:annotatedTarget "Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate." . [] oboInOwl:hasDbXref , "http://naildystrophy.com/" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001810 ; owl:annotatedTarget "Poor toenail formation" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001812 ; owl:annotatedTarget "When viewed on end (with the finger tip pointing toward the examiner's eye) the curve of the fingernail forms a tighter curve of convexity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001814 ; owl:annotatedTarget "Deeply placed nails." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "Fe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001814 ; owl:annotatedTarget "Deep-set nails" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001816 ; owl:annotatedTarget "Nail that appears thin when viewed on end." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001816 ; owl:annotatedTarget "Thin nail" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "Iron" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001816 ; owl:annotatedTarget "Thin nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001817 ; owl:annotatedTarget "Absence of a fingernail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001817 ; owl:annotatedTarget "Absent fingernail" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "fer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001817 ; owl:annotatedTarget "Anonychia of fingernails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001818 ; owl:annotatedTarget "The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia)." . [] a owl:Axiom ; rdfs:label "Paronychia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001818 ; owl:annotatedTarget "MEDDRA:10034016" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001820 ; owl:annotatedTarget "White discoloration of the nails." . [] a owl:Axiom ; rdfs:label "Leukonychia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001820 ; owl:annotatedTarget "MEDDRA:10050658" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001820 ; owl:annotatedTarget "White discoloration of nails" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "ferrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001821 ; owl:annotatedTarget "Increased width of nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001821 ; owl:annotatedTarget "Broad fingernails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001821 ; owl:annotatedTarget "Broad nail" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001821 ; owl:annotatedTarget "Wide fingernails" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "hierro" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001822 ; owl:annotatedTarget "Lateral deviation of the great toe (i.e., in the direction of the little toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001822 ; owl:annotatedTarget "Bunion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133748 ; owl:annotatedTarget "citrate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18248 ; owl:annotatedTarget "iron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001824 ; owl:annotatedTarget "Reduction of total body weight." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001827 ; owl:annotatedTarget "Congenital occlusion of a tube in the genital tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001829 ; owl:annotatedTarget "A kind of polydactyly characterized by the presence of a supernumerary toe or toes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001829 ; owl:annotatedTarget "Duplication of bones of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001830 ; owl:annotatedTarget "Polydactyly of the foot most commonly refers to the presence of six toes on one foot. Postaxial polydactyly affects the lateral ray and the duplication may range from a well-formed articulated digit to a rudimentary digit." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001830 ; owl:annotatedTarget "Extra toe attached near the little toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001831 ; owl:annotatedTarget "A toe that appears disproportionately short compared to the foot." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001831 ; owl:annotatedTarget "Short toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001831 ; owl:annotatedTarget "Short toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001831 ; owl:annotatedTarget "Stubby toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001832 ; owl:annotatedTarget "Abnormalities of the metatarsal bones (i.e. of five tubular bones located between the tarsal bones of the hind- and mid-foot and the phalanges of the toes)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001832 ; owl:annotatedTarget "Abnormality of the long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001833 ; owl:annotatedTarget "Increased back to front length of the foot." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001833 ; owl:annotatedTarget "Disproportionately large feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001833 ; owl:annotatedTarget "Long foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001833 ; owl:annotatedTarget "large feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001833 ; owl:annotatedTarget "long feet" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "Beilstein:1722296" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001836 ; owl:annotatedTarget "Camptodactyly is a painless flexion contracture of the proximal interphalangeal (PIP) joint that is usually gradually progressive. This term refers to camptodactyly of one or more toes." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "CAS:616-07-9" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001837 ; owl:annotatedTarget "Visible increase in width of the non-hallux digit without an increase in the dorso-ventral dimension." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001837 ; owl:annotatedTarget "Broad toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001837 ; owl:annotatedTarget "Wide toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "Gmelin:847696" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "The presence of both a prominent heel and a convex contour of the sole." . [] a owl:Axiom ; rdfs:label "Vertical talus" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "MEDDRA:10066242" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "Rocker bottom feet" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_133748 ; owl:annotatedTarget "citrate anions" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "PMID:15449570" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "Rocker bottom foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "Rocker-bottom feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001838 ; owl:annotatedTarget "Rockerbottom feet" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001839 ; owl:annotatedTarget "A condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001839 ; owl:annotatedTarget "Lobster-claw foot deformity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001839 ; owl:annotatedTarget "Split foot" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001839 ; owl:annotatedTarget "Split-foot" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001840 ; owl:annotatedTarget "The metatarsals are deviated medially (tibially), that is, the bones in the front half of the foot bend or turn in toward the body." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001840 ; owl:annotatedTarget "Front half of foot turns inward" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001841 ; owl:annotatedTarget "Duplication of all or part of the first ray." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001841 ; owl:annotatedTarget "Partial/complete duplication of the phalanges of the big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001841 ; owl:annotatedTarget "Preaxial polydactyly of the feet" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "Reaxys:1722296" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001844 ; owl:annotatedTarget "This term applies for all abnormalities of the big toe, also called hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001844 ; owl:annotatedTarget "Abnormality of the big toe" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001845 ; owl:annotatedTarget "Describes a foot digit resting on the dorsal surface of an adjacent digit when the foot is at rest. Initially clawing may be dynamic and only noticeable on walking. Over time the plantar plate tears, subluxation occurs at the metatarsophalangeal joint (MTPJ), and the deformity becomes permanent." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001845 ; owl:annotatedTarget "Overlapping toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001845 ; owl:annotatedTarget "Overlapping toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001845 ; owl:annotatedTarget "Overriding toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001845 ; owl:annotatedTarget "Crossover toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "2,5-diaminopentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001847 ; owl:annotatedTarget "Increased length of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001847 ; owl:annotatedTarget "Long big toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "Ornithine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001848 ; owl:annotatedTarget "This is a postural deformity in which the foot is positioned up against the tibia. The heel (calcaneus) is positioned downward (that is, the ankle is flexed upward), and the heel is turned outward (valgus)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001848 ; owl:annotatedTarget "Foot and ankle bend up toward shin of leg" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "ornithine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001849 ; owl:annotatedTarget "A developmental defect resulting in the presence of fewer than the normal number of toes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001849 ; owl:annotatedTarget "Missing toes" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "2,5-Diaminopentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001850 ; owl:annotatedTarget "An abnormality of the tarsus are the cluster of seven bones in the foot between the tibia and fibula and the metatarsus, including the calcaneus (heel) bone and the talus (ankle) bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001850 ; owl:annotatedTarget "Abnormal ankle bones" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "A widely spaced gap between the first toe (the great toe) and the second toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Gap between 1st and 2nd toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Gap between first and second toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "2,5-Diaminovaleric acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Increased space between first and second toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Sandal gap between first and second toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Wide space between 1st, 2nd toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Wide space between first and second toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Wide-spaced big toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Widely spaced 1st-2nd toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Widely spaced first and second toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Widened gap 1st-2nd toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001852 ; owl:annotatedTarget "Widened gap first and second toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "DL-Ornithine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001853 ; owl:annotatedTarget "Notched outermost bones of toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134179 ; owl:annotatedTarget "VOC" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18257 ; owl:annotatedTarget "Orn" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001854 ; owl:annotatedTarget "Gout affecting the Metatarsophalangeal joint of big toe." . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001857 ; owl:annotatedTarget "Short distance from the end of the toe to the most distal interphalangeal crease or distal interphalangeal joint flexion point, i.e., abnormally short distal phalanx of toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001857 ; owl:annotatedTarget "Short outermost bone of toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001863 ; owl:annotatedTarget "Bending or curvature of a toe in the tibial direction (i.e., towards the big toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001863 ; owl:annotatedTarget "Toe curvature" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001864 ; owl:annotatedTarget "Bending or curvature of a fifth toe in the tibial direction (i.e., towards the big toe)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001864 ; owl:annotatedTarget "Curvature of the little toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001864 ; owl:annotatedTarget "Curvature of the pinkie toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001864 ; owl:annotatedTarget "Curvature of the pinky toe" . [] oboInOwl:hasDbXref , "PMID:31633102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001868 ; owl:annotatedTarget "The spontaneous detachment of a foot from the body due to long standing pathology." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001869 ; owl:annotatedTarget "The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001869 ; owl:annotatedTarget "Deep wrinkles in soles of feet" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Beilstein:2710227" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001871 ; owl:annotatedTarget "An abnormality of the hematopoietic system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001871 ; owl:annotatedTarget "Abnormality of blood and blood-forming tissues" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001871 ; owl:annotatedTarget "Abnormality of the haematopoietic system" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "CAS:6893-02-3" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001871 ; owl:annotatedTarget "Haematological abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001872 ; owl:annotatedTarget "An abnormality of platelets." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001872 ; owl:annotatedTarget "Platelet abnormalities" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "CAS:6893-02-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001873 ; owl:annotatedTarget "A reduction in the number of circulating thrombocytes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001873 ; owl:annotatedTarget "Low platelet count" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Drug_Central:1585" . [] oboInOwl:hasDbXref , "PMID:21094463", "PMID:26819959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001874 ; owl:annotatedTarget "A neutrophil abnormality." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001874 ; owl:annotatedTarget "Abnormality of neutrophils" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134179 ; owl:annotatedTarget "VOCs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "PMID:11738632" . [] oboInOwl:hasDbXref , "PMID:25642312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001875 ; owl:annotatedTarget "An abnormally low number of neutrophils in the peripheral blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001875 ; owl:annotatedTarget "Low blood neutrophil count" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001875 ; owl:annotatedTarget "Low neutrophil count" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001875 ; owl:annotatedTarget "Neutropoenia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "PMID:15206581" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "PMID:19339791" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001876 ; owl:annotatedTarget "An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001876 ; owl:annotatedTarget "Low blood cell count" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001876 ; owl:annotatedTarget "Pancytopaenia" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Reaxys:2710227" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001877 ; owl:annotatedTarget "Any structural abnormality of erythrocytes (red-blood cells)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001878 ; owl:annotatedTarget "A type of anemia caused by premature destruction of red blood cells (hemolysis)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001878 ; owl:annotatedTarget "Hemolytic anaemia" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "3,3',5-triiodo-L-thyronine" . [] oboInOwl:hasDbXref , "PMID:23154224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001879 ; owl:annotatedTarget "An abnormal count or structure of eosinophils." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "3,5,3'-Triiodo-L-thyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001880 ; owl:annotatedTarget "Increased count of eosinophils in the blood." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "3,5,3'-Triiodothyronine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001880 ; owl:annotatedTarget "High blood eosinophil count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001881 ; owl:annotatedTarget "An abnormality of leukocytes." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "3,5,3'TRIIODOTHYRONINE" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001882 ; owl:annotatedTarget "An abnormal decreased number of leukocytes in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001882 ; owl:annotatedTarget "Decreased blood leukocyte number" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001882 ; owl:annotatedTarget "Low white blood cell count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001883 ; owl:annotatedTarget "A deformity of foot and ankle that has different subtypes that are talipes equinovarus, talipes equinovalgus, talipes calcaneovarus and talipes calcaneovalgus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001883 ; owl:annotatedTarget "Talipes foot deformities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001884 ; owl:annotatedTarget "Talipes calcaneovalgus is a flexible foot deformity (as opposed to a rigid congenital vertical talus foot deformity) that can either present as a positional or structural foot deformity depending on severity and/or causality. The axis of calcaneovalgus deformity is in the tibiotalar joint, where the foot is positioned in extreme hyperextension. On inspection, the foot has an \"up and out\" appearance, with the dorsal forefoot practically touching the anterior aspect of the ankle and lower leg." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "L-3,5,3'-Triiodothyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001885 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the second toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001885 ; owl:annotatedTarget "Short second toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001886 ; owl:annotatedTarget "Foot bone infection" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134179 ; owl:annotatedTarget "volatile organic compounds" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "L-T3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001888 ; owl:annotatedTarget "A reduced number of lymphocytes in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001888 ; owl:annotatedTarget "Decreased blood lymphocyte number" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001888 ; owl:annotatedTarget "Low lymphocyte number" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Liothyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001889 ; owl:annotatedTarget "Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001889 ; owl:annotatedTarget "Megaloblastic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001890 ; owl:annotatedTarget "An autoimmune form of hemolytic anemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001890 ; owl:annotatedTarget "Autoimmune hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001891 ; owl:annotatedTarget "Ferropenic" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001891 ; owl:annotatedTarget "Iron deficiency anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001891 ; owl:annotatedTarget "Iron-deficiency anaemia" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001892 ; owl:annotatedTarget "An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001892 ; owl:annotatedTarget "Bleeding tendency" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "T3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001894 ; owl:annotatedTarget "Increased numbers of platelets in the peripheral blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001894 ; owl:annotatedTarget "Increased number of platelets in blood" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001895 ; owl:annotatedTarget "Normochromic anaemia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "T3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001896 ; owl:annotatedTarget "A reduced number of reticulocytes in the peripheral blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001897 ; owl:annotatedTarget "A kind of anemia in which the volume of the red blood cells is normal." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001897 ; owl:annotatedTarget "Normocytic anaemia" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Tertroxin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001898 ; owl:annotatedTarget "The presence of an increased mass of red blood cells in the circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001898 ; owl:annotatedTarget "Increased RBC mass" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001899 ; owl:annotatedTarget "An elevation above the normal ratio of the volume of red blood cells to the total volume of blood." . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Tresitope" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001899 ; owl:annotatedTarget "Increased Hct" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "Triiodothyronine" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001900 ; owl:annotatedTarget "Increased Hb" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001900 ; owl:annotatedTarget "Increased haemoglobin" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "liothyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001901 ; owl:annotatedTarget "Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001901 ; owl:annotatedTarget "Abnormally shaped erythrocytes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001901 ; owl:annotatedTarget "Increased red blood cells" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "liothyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001902 ; owl:annotatedTarget "Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134249 ; owl:annotatedTarget "alkanesulfonate oxoanions" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "liothyroninum" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18258 ; owl:annotatedTarget "liotironina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001903 ; owl:annotatedTarget "A reduction in erythrocytes volume or hemoglobin concentration." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001903 ; owl:annotatedTarget "Low number of red blood cells or haemoglobin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001903 ; owl:annotatedTarget "Low number of red blood cells or hemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001903 ; owl:annotatedTarget "Decreased haemoglobin" . [] oboInOwl:hasDbXref , "PMID:25642312" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001904 ; owl:annotatedTarget "A type of neutropenia that is observed in the presence of granulocyte-specific antibodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001905 ; owl:annotatedTarget "Thrombocytopenia with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001907 ; owl:annotatedTarget "The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site." . [] oboInOwl:hasDbXref hp:layperson, ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001907 ; owl:annotatedTarget "Blood clot in blood vessel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001908 ; owl:annotatedTarget "Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001908 ; owl:annotatedTarget "Hypoplastic anaemia" . [] oboInOwl:hasDbXref , "NCIT:C3161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001909 ; owl:annotatedTarget "A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001909 ; owl:annotatedTarget "Blood cancer" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001909 ; owl:annotatedTarget "Leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001911 ; owl:annotatedTarget "Any structural abnormality or abnormal count of granulocytes." . [] oboInOwl:hasDbXref , "PMID:24075190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001912 ; owl:annotatedTarget "Any structural abnormality or abnormal count of basophils." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001913 ; owl:annotatedTarget "An abnormally reduced number of granulocytes in the blood." . [] oboInOwl:hasDbXref , "PMID:21239768" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001915 ; owl:annotatedTarget "Aplastic anemia is defined as pancytopenia with a hypocellular marrow." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001915 ; owl:annotatedTarget "Aplastic anaemia" . [] oboInOwl:hasDbXref , "PMID:25852856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001917 ; owl:annotatedTarget "A form of amyloidosis that affects the kidney. On hematoxylin and eosin stain, amyloid is identified as extracellular amorphous material that is lightly eosinophilic. These deposits often stain weakly for periodic acid Schiff (PAS), demonstrate a blue-to-gray hue on the trichrome stain and are typically negative on the Jones methenamine silver (JMS) stain. These tinctorial properties contrast with the histologic appearance of collagen, a major component of basement membranes, mesangial matrix and areas of sclerosis, which demonstrates strong positivity for PAS and JMS (See Figure 1 of PMID:25852856)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001919 ; owl:annotatedTarget "Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001919 ; owl:annotatedTarget "Acute kidney failure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001920 ; owl:annotatedTarget "The presence of stenosis of the renal artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001920 ; owl:annotatedTarget "Narrowing of kidney artery" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "CAS:11034-93-8" . [] oboInOwl:hasDbXref , "PMID:20633042" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001922 ; owl:annotatedTarget "The presence of clear, sharply defined vacuoles in the lymphocyte cytoplasm." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "CAS:11034-93-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001923 ; owl:annotatedTarget "An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001923 ; owl:annotatedTarget "Increased immature red blood cells" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001923 ; owl:annotatedTarget "Increased number of immature red blood cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001924 ; owl:annotatedTarget "Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001924 ; owl:annotatedTarget "Hypersideremic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001924 ; owl:annotatedTarget "Sideroblastic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001927 ; owl:annotatedTarget "Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:1528196" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001928 ; owl:annotatedTarget "An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001928 ; owl:annotatedTarget "Haemorrhagic disorders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001929 ; owl:annotatedTarget "Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001930 ; owl:annotatedTarget "Nonspherocytic hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001931 ; owl:annotatedTarget "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134249 ; owl:annotatedTarget "alkanesulfonates" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:15495792" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:15661151" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001933 ; owl:annotatedTarget "This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001933 ; owl:annotatedTarget "Bleeding below the skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001933 ; owl:annotatedTarget "Subcutaneous haemorrhage" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001934 ; owl:annotatedTarget "Excessive bleeding after minor trauma" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001934 ; owl:annotatedTarget "Frequent bleeding with trauma" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001934 ; owl:annotatedTarget "Prolonged bleeding after minor trauma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001935 ; owl:annotatedTarget "A kind of anemia in which the volume of the red blood cells is reduced." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001935 ; owl:annotatedTarget "Microcytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001937 ; owl:annotatedTarget "Microangiopathic hemolytic anaemia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:1601891" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001939 ; owl:annotatedTarget "Laboratory abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001939 ; owl:annotatedTarget "Metabolism abnormality" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:1724444" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:21252262" . [] oboInOwl:hasDbXref , "PMID:24381489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001941 ; owl:annotatedTarget "Abnormal acid accumulation or depletion of base." . [] oboInOwl:hasDbXref , "PMID:17936961", "PMID:31418093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001942 ; owl:annotatedTarget "Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:21376640" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001943 ; owl:annotatedTarget "A decreased concentration of glucose in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001943 ; owl:annotatedTarget "Low blood sugar" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001944 ; owl:annotatedTarget "Dehydration" . [] oboInOwl:hasDbXref , "PMID:9759682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001945 ; owl:annotatedTarget "Body temperature elevated above the normal range." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001945 ; owl:annotatedTarget "Fever" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:2448252" . [] oboInOwl:hasDbXref , "PMID:28278308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001946 ; owl:annotatedTarget "Presence of elevated levels of ketone bodies in the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001946 ; owl:annotatedTarget "High levels of ketone bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001947 ; owl:annotatedTarget "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001947 ; owl:annotatedTarget "Accumulation of acid in body due to kidney problem" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:2456994" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:3220436" . [] oboInOwl:hasDbXref , "PMID:24381489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001948 ; owl:annotatedTarget "Depletion of acid or accumulation base in the body fluids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001950 ; owl:annotatedTarget "Alkalosis due to excess loss of carbon dioxide from the body." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:4026313" . [] oboInOwl:hasDbXref "PMID:29763085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001952 ; owl:annotatedTarget "Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001952 ; owl:annotatedTarget "Glucose intolerance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001953 ; owl:annotatedTarget "A type of diabetic metabolic abnormality with an accumulation of ketone bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001954 ; owl:annotatedTarget "Periodic (episodic or recurrent) bouts of fever." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001954 ; owl:annotatedTarget "Episodic fever" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001954 ; owl:annotatedTarget "Increased body temperature, episodic" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134249 ; owl:annotatedTarget "an alkanesulfonate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:7287743" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001954 ; owl:annotatedTarget "Intermittent fever" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001955 ; owl:annotatedTarget "Episodes of fever for which no infectious cause can be identified." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001955 ; owl:annotatedTarget "Unexplained fevers" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:7690848" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001956 ; owl:annotatedTarget "Obesity located preferentially in the trunk of the body as opposed to the extremities." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001956 ; owl:annotatedTarget "Truncal obesity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:7691279" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001959 ; owl:annotatedTarget "Extreme thirst" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001961 ; owl:annotatedTarget "Small heart" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "PMID:8161226" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001961 ; owl:annotatedTarget "Underdeveloped heart" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001962 ; owl:annotatedTarget "A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001962 ; owl:annotatedTarget "Missed heart beat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001962 ; owl:annotatedTarget "Palpitations" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001962 ; owl:annotatedTarget "Skipped heart beat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001963 ; owl:annotatedTarget "A type of hearing impairment prominently characterized by a difficulty in understanding speech, rather than an inability to hear speech. Poor speech discrimination is a very common symptom of high frequency hearing loss." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001963 ; owl:annotatedTarget "Abnormal speech discrimination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001963 ; owl:annotatedTarget "Poor speech discrimination" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001964 ; owl:annotatedTarget "Absence or underdevelopment of the metatarsal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001964 ; owl:annotatedTarget "Absent/small long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001964 ; owl:annotatedTarget "Absent/underdeveloped long bone of foot" . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "(Gal)2 (GalNAc)1 (Glc)1 (Cer)1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001965 ; owl:annotatedTarget "Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001965 ; owl:annotatedTarget "Abnormality of the scalp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001965 ; owl:annotatedTarget "Anomaly of scalp" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "CTH/Gb4" . [] oboInOwl:hasDbXref , "PMID:19470685", "PMID:20828589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001966 ; owl:annotatedTarget "An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001967 ; owl:annotatedTarget "Diffuse sclerosis of the mesangium, as manifestated by diffuse mesangial matrix expansion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001969 ; owl:annotatedTarget "An abnormality that involves the tubules and interstitial tissue of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001970 ; owl:annotatedTarget "A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001971 ; owl:annotatedTarget "A malfunctioning of the spleen in which it prematurely destroys red blood cells." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "GalNAc-1->3-Gal-1->4-Gal-1->4-Glc-Cer" . [] oboInOwl:hasDbXref , "PMID:19202968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001972 ; owl:annotatedTarget "A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001972 ; owl:annotatedTarget "Macrocytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001973 ; owl:annotatedTarget "The presence of thrombocytopenia in combination with detection of antiplatelet antibodies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "GalNAcbeta1-3-Galalpha1-4Galbeta1-4Glcbeta1-1Cer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001974 ; owl:annotatedTarget "An abnormal increase in the number of leukocytes in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001974 ; owl:annotatedTarget "Elevated white blood count" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001974 ; owl:annotatedTarget "High white blood count" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001974 ; owl:annotatedTarget "Increased blood leukocyte number" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001975 ; owl:annotatedTarget "Decreased cell membrane concentration of glycoprotein IIb-IIIa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001976 ; owl:annotatedTarget "An abnormality of coagulation related to a decreased concentration of antithrombin-III." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Gb4 Globoside" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001977 ; owl:annotatedTarget "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001977 ; owl:annotatedTarget "Abnormal blood clot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001978 ; owl:annotatedTarget "The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "1-hydroxy-2-methoxybenzenes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Gb4 Globotetraosyl ceramide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001980 ; owl:annotatedTarget "Abnormal increased number of megaloblasts in the bone marrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001981 ; owl:annotatedTarget "The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood." . [] oboInOwl:hasDbXref , "PMID:8797061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001982 ; owl:annotatedTarget "An abnormality of histiocytes, in which the cells take on a sea blue appearance due to abnormally increased lipid content. Histiocytes are a type of macrophage. Sea-blue histiocytes are typically large macrophages from 20 to 60 micrometers in diameter with a single eccentric nucleus whose cytoplasm if packed with sea-blue or blue-green granules when stained with Wright-Giemsa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001983 ; owl:annotatedTarget "A reduction in the expression of CD43 on the cell surface of lymphocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001985 ; owl:annotatedTarget "A decreased concentration of glucose in the blood associated with a reduced concentration of ketone bodies." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Gb4Cer" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001987 ; owl:annotatedTarget "An increased concentration of ammonia in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001987 ; owl:annotatedTarget "High blood ammonia levels" . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Gb4Cer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "GbOse4Cer" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001988 ; owl:annotatedTarget "Recurrent episodes of decreased concentration of glucose in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001988 ; owl:annotatedTarget "Recurrent low blood sugar levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001988 ; owl:annotatedTarget "hypoglycaemia, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001988 ; owl:annotatedTarget "hypoglycemia, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Foetal akinesia sequence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Early severe fetal akinesia sequence" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Early severe foetal akinesia sequence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Fetal akinesia" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Gbose4Cer" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001989 ; owl:annotatedTarget "Foetal akinesia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001991 ; owl:annotatedTarget "Absence or hypoplasia of toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001991 ; owl:annotatedTarget "Absent/small toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Globoside GL-4" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001991 ; owl:annotatedTarget "Absent/underdeveloped toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001991 ; owl:annotatedTarget "Absent/hypoplastic toes" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Globoside I" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001992 ; owl:annotatedTarget "Excretion of non-amino organic acids in urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001993 ; owl:annotatedTarget "Acidosis resulting from accumulation of ketone bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001994 ; owl:annotatedTarget "An inability of the tubules in the kidney to reabsorb small molecules, causing increased urinary loss of electrolytes (sodium, potassium, bicarbonate), minerals, glucose, amino acids, and water." . [] oboInOwl:hasDbXref "PMID:29493965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001995 ; owl:annotatedTarget "Acidosis (pH less than 7.35) that develops with an increase in ionic chloride." . [] oboInOwl:hasDbXref , "PMID:15882309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001996 ; owl:annotatedTarget "Longstanding metabolic acidosis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Globotetraosyl ceramide" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "N-Acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001997 ; owl:annotatedTarget "Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001998 ; owl:annotatedTarget "Low blood sugar in newborn" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "N-Acetyl-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "An abnormal morphology (form) of the face or its components." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Deformity of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Malformation of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Abnormal facial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Abnormal morphology of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Dysmorphic facies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "2-methoxyphenol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosylceramides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Facial dysmorphism" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Unusual facial appearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Distortion of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0001999 ; owl:annotatedTarget "Funny looking face" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "Slt-iiv receptor" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002000 ; owl:annotatedTarget "Reduced distance from the anterior border of the naris to the subnasale." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002000 ; owl:annotatedTarget "Decreased length of columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002000 ; owl:annotatedTarget "Hypoplasia of columella" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "VT2vp1 Receptor" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002002 ; owl:annotatedTarget "Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal base and upper vermillion border." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002002 ; owl:annotatedTarget "Increased depth of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002002 ; owl:annotatedTarget "Pronounced philtrum" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002003 ; owl:annotatedTarget "Increased size of forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002003 ; owl:annotatedTarget "Increased size of frontal region of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002003 ; owl:annotatedTarget "Large forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002003 ; owl:annotatedTarget "Hyperplasia of forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002003 ; owl:annotatedTarget "Hypertrophy of forehead" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002006 ; owl:annotatedTarget "A congenital malformation with a cleft (gap or opening) in the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002006 ; owl:annotatedTarget "Cleft of the face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002006 ; owl:annotatedTarget "Facial cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002006 ; owl:annotatedTarget "Tessier facial cleft" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002006 ; owl:annotatedTarget "Facial clefts" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18259 ; owl:annotatedTarget "globoside Gb4Cer (d18:1(4E))" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002007 ; owl:annotatedTarget "Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002007 ; owl:annotatedTarget "Frontal protruberance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002007 ; owl:annotatedTarget "Skull bossing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002009 ; owl:annotatedTarget "A facial appearance characteristic of a fetus or neonate due to oligohydramnios experienced in the womb, comprising ocular hypertelorism, low-set ears, receding chin, and flattening of the nose." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18282 ; owl:annotatedTarget "Base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Decreased breadth of upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Decreased transverse dimension of maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Decreased width of maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Decreased width of upper jaw bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18282 ; owl:annotatedTarget "nucleobases" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Narrow upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Transverse hypoplasia of maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Transverse maxillary deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002010 ; owl:annotatedTarget "Transverse maxillary insufficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002011 ; owl:annotatedTarget "A structural abnormality of the central nervous system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002011 ; owl:annotatedTarget "Morphological abnormality of the CNS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002012 ; owl:annotatedTarget "An abnormality of the viscera of the abdomen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002012 ; owl:annotatedTarget "Abnormality of the abdominal organs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002013 ; owl:annotatedTarget "Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions." . [] a owl:Axiom ; rdfs:label "Vomiting" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002013 ; owl:annotatedTarget "MEDDRA:10047700" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002013 ; owl:annotatedTarget "Throwing up" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002013 ; owl:annotatedTarget "Vomiting" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "CAS:2438-80-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002014 ; owl:annotatedTarget "Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002014 ; owl:annotatedTarget "Diarrhea" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002014 ; owl:annotatedTarget "Diarrhoea" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002014 ; owl:annotatedTarget "Watery stool" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "2-methoxyphenol derivative" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "PMID:20877283" . [] oboInOwl:hasDbXref "PMID:28846339" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:id ; owl:annotatedSource obo:HP_0002014 ; owl:annotatedTarget "HP:0002014" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002015 ; owl:annotatedTarget "Difficulty in swallowing." . [] a owl:Axiom ; rdfs:label "Dysphagia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002015 ; owl:annotatedTarget "MEDDRA:10013950" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002015 ; owl:annotatedTarget "Poor swallowing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002015 ; owl:annotatedTarget "Swallowing difficulties" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002015 ; owl:annotatedTarget "Swallowing difficulty" . [] oboInOwl:hasDbXref "PMID:26770271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002017 ; owl:annotatedTarget "Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002017 ; owl:annotatedTarget "Nausea and vomiting" . [] oboInOwl:hasDbXref , "PMID:26770271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002018 ; owl:annotatedTarget "A sensation of unease in the stomach together with an urge to vomit." . [] a owl:Axiom ; rdfs:label "Nausea" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002018 ; owl:annotatedTarget "MEDDRA:10028813" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "6-deoxy-L-galactose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002018 ; owl:annotatedTarget "Nausea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002019 ; owl:annotatedTarget "Infrequent or difficult evacuation of feces." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002019 ; owl:annotatedTarget "Constipation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "L-fucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "Acid reflux" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "Acid reflux disease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "GERD" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "Gastro-oesophageal reflux" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002020 ; owl:annotatedTarget "Heartburn" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "(-)-L-fucose" . [] oboInOwl:hasDbXref , "PMID:32310391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002021 ; owl:annotatedTarget "Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis, is an uncommon condition in infants characterized by abnormal thickening of the pylorus muscles in the stomach leading to gastric outlet obstruction. Clinically infants are well at birth. Then, at 3 to 6 weeks of age, the infants present with projectile vomiting, potentially leading to dehydration and weight loss." . [] a owl:Axiom ; rdfs:label "Pyloric stenosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002021 ; owl:annotatedTarget "MEDDRA:10037621" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "(-)-fucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002023 ; owl:annotatedTarget "Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract." . [] a owl:Axiom ; rdfs:label "Anal atresia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002023 ; owl:annotatedTarget "MEDDRA:10002120" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002023 ; owl:annotatedTarget "Absent anus" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "L-(-)-fucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002024 ; owl:annotatedTarget "Impaired ability to absorb one or more nutrients from the intestine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002024 ; owl:annotatedTarget "Intestinal malabsorption" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002024 ; owl:annotatedTarget "Malabsorption" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "L-Fuc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002025 ; owl:annotatedTarget "Abnormal narrowing of the anal opening." . [] a owl:Axiom ; rdfs:label "Anal stenosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002025 ; owl:annotatedTarget "MEDDRA:10002176" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002025 ; owl:annotatedTarget "Narrowing of anal opening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Gastro pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Gastrointestinal pain" . [] a owl:Axiom ; rdfs:label "Abdominal pain" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "MEDDRA:10000081" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Abdominal pain" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18287 ; owl:annotatedTarget "L-galactomethylose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Pain in stomach" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Stomach pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Abdominal discomfort" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002027 ; owl:annotatedTarget "Upset stomach" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "Chronic diarrhea" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "Chronic diarrhoea" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "Diarrhea, recurrent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "Recurrent diarrhea" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002028 ; owl:annotatedTarget "Recurrent diarrhoea" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "Alkane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002031 ; owl:annotatedTarget "A structural abnormality of the esophagus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002031 ; owl:annotatedTarget "Abnormal oesophagus morphology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002031 ; owl:annotatedTarget "Abnormality of esophagus structure" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alkane" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002031 ; owl:annotatedTarget "Abnormality of oesophagus structure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002031 ; owl:annotatedTarget "Anomaly of the oesophagus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002032 ; owl:annotatedTarget "A developmental defect resulting in complete obliteration of the lumen of the esophagus such that the esophagus ends in a blind pouch rather than connecting to the stomach." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "2-methoxyphenol derivatives" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alkanes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002032 ; owl:annotatedTarget "Birth defect in which part of esophagus did not develop" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002032 ; owl:annotatedTarget "Birth defect in which part of oesophagus did not develop" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002033 ; owl:annotatedTarget "An inadequate sucking reflex, resulting in the difficult of newborns to be breast-fed." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "Alkan" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002033 ; owl:annotatedTarget "Poor suck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002033 ; owl:annotatedTarget "Poor sucking" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002034 ; owl:annotatedTarget "An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "RH" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002034 ; owl:annotatedTarget "Abnormality of the rectum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002034 ; owl:annotatedTarget "Anomaly of the rectum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002035 ; owl:annotatedTarget "Protrusion of the rectal mucous membrane through the anus." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alcane" . [] a owl:Axiom ; rdfs:label "Rectal prolapse" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002035 ; owl:annotatedTarget "MEDDRA:10038077" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002035 ; owl:annotatedTarget "Rectum protrudes through anus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002035 ; owl:annotatedTarget "Rectal prolapsed" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alcanes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002036 ; owl:annotatedTarget "The presence of a hernia in which the upper part of the stomach, i.e., mainly the gastric cardia protrudes through the diaphragmatic esophageal hiatus." . [] a owl:Axiom ; rdfs:label "Hiatus hernia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002036 ; owl:annotatedTarget "MEDDRA:10020028" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002036 ; owl:annotatedTarget "Stomach hernia" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alcano" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002037 ; owl:annotatedTarget "Inflammation of the large intestine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002037 ; owl:annotatedTarget "Inflammatory bowel disease" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "alcanos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002039 ; owl:annotatedTarget "A lack or loss of appetite for food (as a medical condition)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002039 ; owl:annotatedTarget "Anorexia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002040 ; owl:annotatedTarget "Extreme dilation of the submucusoal veins in the lower portion of the esophagus." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18310 ; owl:annotatedTarget "an alkane" . [] a owl:Axiom ; rdfs:label "Varices oesophageal" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002040 ; owl:annotatedTarget "MEDDRA:10056091" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002040 ; owl:annotatedTarget "Enlarged vein in esophagus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002040 ; owl:annotatedTarget "Enlarged vein in oesophagus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002041 ; owl:annotatedTarget "Intractable diarrhoea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002043 ; owl:annotatedTarget "A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002043 ; owl:annotatedTarget "Narrowing of esophagus due to inflammation and scar tissue" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002043 ; owl:annotatedTarget "Narrowing of oesophagus due to inflammation and scar tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002044 ; owl:annotatedTarget "A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration." . [] a owl:Axiom ; rdfs:label "Zollinger-Ellison syndrome" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002044 ; owl:annotatedTarget "MEDDRA:10048281" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002045 ; owl:annotatedTarget "Reduced body temperature due to failed thermoregulation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002045 ; owl:annotatedTarget "Abnormally low body temperature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002045 ; owl:annotatedTarget "Hypothermia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002046 ; owl:annotatedTarget "The inability to maintain a comfortable body temperature in warm or hot weather." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002046 ; owl:annotatedTarget "Heat intolerance" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002046 ; owl:annotatedTarget "Intolerance to heat and fevers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002047 ; owl:annotatedTarget "Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "CAS:14000-31-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002048 ; owl:annotatedTarget "Atrophy of the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002049 ; owl:annotatedTarget "A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002054 ; owl:annotatedTarget "Heavy brow of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002054 ; owl:annotatedTarget "Heavy supraorbital ridge" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "2-methoxyphenols" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "Gmelin:26938" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002056 ; owl:annotatedTarget "An abnormality of the glabella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002056 ; owl:annotatedTarget "Abnormality of the area between the eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002056 ; owl:annotatedTarget "Deformity of the area between the eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002056 ; owl:annotatedTarget "Malformation of the area between the eyebrows" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "diphosphate" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002057 ; owl:annotatedTarget "Forward protrusion of the glabella." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002057 ; owl:annotatedTarget "Convex glabella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002057 ; owl:annotatedTarget "Hyperplasia of glabella" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002057 ; owl:annotatedTarget "Prominent area between the eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002057 ; owl:annotatedTarget "Protruding area between the eyebrows" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "mu-oxido-bis(trioxidophosphate)(4-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002058 ; owl:annotatedTarget "A facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002058 ; owl:annotatedTarget "Myopathic facial appearance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002059 ; owl:annotatedTarget "Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "mu-oxo-hexaoxodiphosphate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002059 ; owl:annotatedTarget "Degeneration of cerebrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002060 ; owl:annotatedTarget "Any structural abnormality of the telencephalon, which is also known as the cerebrum." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "DIPHOSPHATE" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UKT_rschuele" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002061 ; owl:annotatedTarget "Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002062 ; owl:annotatedTarget "Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002063 ; owl:annotatedTarget "Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002063 ; owl:annotatedTarget "Muscle rigidity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "Diphosphat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002063 ; owl:annotatedTarget "Rigidity" . [] oboInOwl:hasDbXref "PMID:25649546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002064 ; owl:annotatedTarget "Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002064 ; owl:annotatedTarget "Spastic walk" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UKT_rschuele" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002066 ; owl:annotatedTarget "A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002066 ; owl:annotatedTarget "Inability to coordinate movements when walking" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002067 ; owl:annotatedTarget "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002067 ; owl:annotatedTarget "Slow movements" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002067 ; owl:annotatedTarget "Slowness of movements" . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002069 ; owl:annotatedTarget "A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002069 ; owl:annotatedTarget "Generalised convulsion" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "Diphosphate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002069 ; owl:annotatedTarget "Grand mal seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002069 ; owl:annotatedTarget "Tonic-clonic convulsion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002069 ; owl:annotatedTarget "Tonic-clonic convulsions" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "P2O7(4-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002070 ; owl:annotatedTarget "A kind of ataxia that affects movements of the extremities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002071 ; owl:annotatedTarget "A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless)." . [] oboInOwl:hasDbXref , "PMID:20589866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002072 ; owl:annotatedTarget "Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities." . [] oboInOwl:hasDbXref , "PMID:11406682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002074 ; owl:annotatedTarget "Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the neuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UKB_tklockgether", "HPO_CONTRIBUTOR:zaferyueksel" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002075 ; owl:annotatedTarget "A type of ataxia characterized by the impairment of the ability to perform rapidly alternating movements, such as pronating and supinating his or her hand on the dorsum of the other hand as rapidly as possible." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002075 ; owl:annotatedTarget "Difficulty performing quick and alternating movements" . [] oboInOwl:hasDbXref , "PMID:15304572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002076 ; owl:annotatedTarget "Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002076 ; owl:annotatedTarget "Intermittent migraine headaches" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002076 ; owl:annotatedTarget "Migraine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002076 ; owl:annotatedTarget "Migraine headache" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "PPi" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002076 ; owl:annotatedTarget "Migraine headaches" . [] oboInOwl:hasDbXref , "PMID:15304572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002077 ; owl:annotatedTarget "A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UKT_rschuele" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002078 ; owl:annotatedTarget "Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "Pyrophosphat" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002078 ; owl:annotatedTarget "Instability or lack of coordination of central trunk muscles" . [] oboInOwl:hasDbXref , "PMID:21263138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002079 ; owl:annotatedTarget "Underdevelopment of the corpus callosum." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002079 ; owl:annotatedTarget "Underdevelopment of part of brain called corpus callosum" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "a guaiacol" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "Pyrophosphate" . [] oboInOwl:hasDbXref , "PMID:16344298" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002080 ; owl:annotatedTarget "A type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger)." . [] oboInOwl:hasDbXref , "PMID:15304572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002083 ; owl:annotatedTarget "Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "[O3POPO3](4-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002084 ; owl:annotatedTarget "A neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18361 ; owl:annotatedTarget "pyrophosphate ion" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002085 ; owl:annotatedTarget "A type of encephalocele (that is, a a protrusion of part of the cranial contents including brain tissue through a congenital opening in the cranium, typically covered with skin or mucous membrane) in the occipital region of the skull. Occipital encephalocele presents as a midline swelling over the occipital bone. It is usually covered with normal full-thickness scalp." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002085 ; owl:annotatedTarget "Brain tissue sticks out through back of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002086 ; owl:annotatedTarget "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "Beilstein:3903772" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002087 ; owl:annotatedTarget "An abnormality of the upper respiratory tract." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002087 ; owl:annotatedTarget "Abnormality of the upper respiratory tract" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002087 ; owl:annotatedTarget "Upper respiratory tract issues" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "CAS:14265-44-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Any structural anomaly of the lung." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Abnormality of lung structure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Abnormality of the lungs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Abnormally shaped lung" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Unusal lung shape" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002088 ; owl:annotatedTarget "Lung disease" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "CAS:14265-44-2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002089 ; owl:annotatedTarget "Poorly developed lungs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002089 ; owl:annotatedTarget "Small lung" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002089 ; owl:annotatedTarget "Underdeveloped lung" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "Gmelin:1997" . [] oboInOwl:source "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "PDBeChem:PO4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002090 ; owl:annotatedTarget "Inflammation of any part of the lung parenchyma." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002090 ; owl:annotatedTarget "Pneumonia" . [] oboInOwl:hasDbXref , "PMID:28194273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002091 ; owl:annotatedTarget "A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002091 ; owl:annotatedTarget "Stiff lung or chest wall causing decreased lung volume" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002091 ; owl:annotatedTarget "Restrictive lung disease" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "Reaxys:3903772" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002092 ; owl:annotatedTarget "Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "catechol monomethyl ether" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "phosphate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002092 ; owl:annotatedTarget "Increased blood pressure in blood vessels of lungs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002092 ; owl:annotatedTarget "Primary pulmonary hypertension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002093 ; owl:annotatedTarget "Respiratory impairment" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "tetraoxidophosphate(3-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002093 ; owl:annotatedTarget "Respiratory function loss" . [] oboInOwl:hasDbXref , "PMID:16914301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Breathing difficulty" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Difficult to breathe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Difficulty breathing" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Dyspnoea" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Shortness of breath" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Trouble breathing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002094 ; owl:annotatedTarget "Panting" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "tetraoxophosphate(3-)" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "tetraoxophosphate(V)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002098 ; owl:annotatedTarget "Breathing difficulties" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002098 ; owl:annotatedTarget "Labored breathing" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002098 ; owl:annotatedTarget "Laboured breathing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002099 ; owl:annotatedTarget "Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002099 ; owl:annotatedTarget "Asthma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002100 ; owl:annotatedTarget "Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "Orthophosphate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002101 ; owl:annotatedTarget "A developmental defect in the formation of pulmonary lobes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002102 ; owl:annotatedTarget "Inflammation of the pleura." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002102 ; owl:annotatedTarget "Inflammation of tissues lining lungs and chest" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002102 ; owl:annotatedTarget "Pleurisy" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "PHOSPHATE ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002103 ; owl:annotatedTarget "An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "PO4(3-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002104 ; owl:annotatedTarget "Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002105 ; owl:annotatedTarget "Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002105 ; owl:annotatedTarget "Coughing up blood" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002105 ; owl:annotatedTarget "Haemoptysis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002105 ; owl:annotatedTarget "Coughing up blood or blood-stained mucus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002107 ; owl:annotatedTarget "Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002107 ; owl:annotatedTarget "Collapsed lung" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002108 ; owl:annotatedTarget "Pneumothorax occurring without traumatic injury to the chest or lung." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "Phosphate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002108 ; owl:annotatedTarget "Spontaneous collapsed lung" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002110 ; owl:annotatedTarget "Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002110 ; owl:annotatedTarget "Permanent enlargement of the airways of the lungs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002113 ; owl:annotatedTarget "Lung infiltrates" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18367 ; owl:annotatedTarget "[PO4](3-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002118 ; owl:annotatedTarget "Any structural abnormality of the cerebral ventricles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002119 ; owl:annotatedTarget "An increase in size of the ventricular system of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002120 ; owl:annotatedTarget "Atrophy of the cortex of the cerebrum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002120 ; owl:annotatedTarget "Decrease in size of the outer layer of the brain due to loss of brain cells" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterised by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "catechol monomethyl ethers" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "Absence seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "Brief seizures with staring spells" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "Generalised non-motor (absence) seizure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "Generalised non-motor seizure" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002121 ; owl:annotatedTarget "Petit mal seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002123 ; owl:annotatedTarget "A generalized myoclonic seizure is a type of generalized motor seizure characterised by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002123 ; owl:annotatedTarget "Generalised myoclonic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002123 ; owl:annotatedTarget "Generalized myoclonic seizures" . [] oboInOwl:hasDbXref , , "PMID:24888723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002126 ; owl:annotatedTarget "Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002126 ; owl:annotatedTarget "More grooves in brain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002127 ; owl:annotatedTarget "Abnormal shape of upper motor neuron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002131 ; owl:annotatedTarget "Periodic spells of incoordination and imbalance, that is, episodes of ataxia typically lasting from 10 minutes to several hours or days." . [] oboInOwl:hasDbXref , "PMID:9279052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002132 ; owl:annotatedTarget "A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002132 ; owl:annotatedTarget "Cavity within brain" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:jalbers", "PMID:26336950", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002133 ; owl:annotatedTarget "Status epilepticus is a type of prolonged seizure resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). It is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002133 ; owl:annotatedTarget "Repeated seizures without recovery between them" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002134 ; owl:annotatedTarget "Abnormality of the basal ganglia." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "Beilstein:8390617" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002135 ; owl:annotatedTarget "The presence of calcium deposition affecting one or more structures of the basal ganglia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002136 ; owl:annotatedTarget "An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002136 ; owl:annotatedTarget "Wide based walk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002138 ; owl:annotatedTarget "Hemorrhage occurring between the arachnoid mater and the pia mater." . [] oboInOwl:hasDbXref "PMID:32054610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002140 ; owl:annotatedTarget "Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002140 ; owl:annotatedTarget "Ischaemic stroke" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002141 ; owl:annotatedTarget "Abnormality of balance" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002141 ; owl:annotatedTarget "Abnormality of equilibrium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002141 ; owl:annotatedTarget "Imbalanced walk" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "CAS:24967-94-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002143 ; owl:annotatedTarget "A structural abnormality of the spinal cord (myelon)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002143 ; owl:annotatedTarget "Abnormality of the spinal cord" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002143 ; owl:annotatedTarget "Spinal cord disease" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "CAS:24967-94-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002144 ; owl:annotatedTarget "During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002144 ; owl:annotatedTarget "Occult spinal dysraphism" . [] oboInOwl:hasDbXref , "PMID:24966676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002145 ; owl:annotatedTarget "A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "Chondroitin sulfate B" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002148 ; owl:annotatedTarget "An abnormally decreased phosphate concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002148 ; owl:annotatedTarget "Low blood phosphate level" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "Dermatan L-iduronate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002149 ; owl:annotatedTarget "An abnormally high level of uric acid in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002149 ; owl:annotatedTarget "High blood uric acid level" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18376 ; owl:annotatedTarget "beta-Heparin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002150 ; owl:annotatedTarget "Elevated urine calcium levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "o-methoxyphenol" . [] oboInOwl:hasDbXref , "PMID:24079682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002151 ; owl:annotatedTarget "Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002151 ; owl:annotatedTarget "Higher than normal levels of lactate in blood" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002152 ; owl:annotatedTarget "An increased concentration of proteins in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002153 ; owl:annotatedTarget "An abnormally increased potassium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002153 ; owl:annotatedTarget "Elevated serum potassium levels" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:16902722", "PMID:4696900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002154 ; owl:annotatedTarget "An elevated concentration of glycine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002154 ; owl:annotatedTarget "Elevated blood glycine levels" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "Beilstein:3539899" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "An abnormal increase in the level of triglycerides in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "Increased circulating Tg levels" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "Increased plasma Tg levels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "Increased plasma triglycerides" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "Increased serum triglycerides" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002155 ; owl:annotatedTarget "Increased triglycerides" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "Gmelin:327522" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "Reaxys:3539899" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002156 ; owl:annotatedTarget "An increased concentration of homocystine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002156 ; owl:annotatedTarget "High urine homocystine levels" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "UM-BBD_compID:c0211" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002157 ; owl:annotatedTarget "An increased concentration of nitrogen compounds in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "phenylacetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002159 ; owl:annotatedTarget "An increased concentration of heparan sulfates in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002159 ; owl:annotatedTarget "Heparan sulphate excretion in urine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "o-methoxyphenols" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "2-phenylacetate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002160 ; owl:annotatedTarget "An increased concentration of homocystine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002160 ; owl:annotatedTarget "Elevated blood homocystine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "2-phenylethanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "phenylacetate anion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:4696900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002161 ; owl:annotatedTarget "An increased concentration of lysine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002161 ; owl:annotatedTarget "Elevated blood lysine" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002162 ; owl:annotatedTarget "Hair on the neck extends more inferiorly than usual." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002162 ; owl:annotatedTarget "Low hairline at back of neck" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "phenylacetate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002164 ; owl:annotatedTarget "The presence of developmental dysplasia of the nail." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002164 ; owl:annotatedTarget "Atypical nail growth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002165 ; owl:annotatedTarget "Inward advance of skin over the nail plate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "A decrease in the ability to perceive vibration in the legs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Decreased lower limb vibratory sense" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Decreased vibratory sense in lower limbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Decreased vibratory sense in the lower extremities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Decreased vibratory sense in the lower limbs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18401 ; owl:annotatedTarget "phenylacetic acid anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Diminished vibratory sensation in the legs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002166 ; owl:annotatedTarget "Impaired vibration sensation in the lower limbs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002167 ; owl:annotatedTarget "Abnormal vocalisation" . [] oboInOwl:hasDbXref "PMID:16247074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002168 ; owl:annotatedTarget "An abnormal pattern of speech in which the words are as if measured or scanned; there is a pause after every syllable, and the syllables themselves are pronounced slowly." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002168 ; owl:annotatedTarget "Explosive speech" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002169 ; owl:annotatedTarget "A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch." . [] oboInOwl:hasDbXref hp:layperson, ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002169 ; owl:annotatedTarget "Involuntary rhythmic muscular contractions and relaxations" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002170 ; owl:annotatedTarget "Hemorrhage occurring within the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002170 ; owl:annotatedTarget "Bleeding within the skull" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002170 ; owl:annotatedTarget "Intracranial haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002171 ; owl:annotatedTarget "Gliosis is the focal proliferation of glial cells in the central nervous system." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002171 ; owl:annotatedTarget "Excess astrocytes in brain" . [] oboInOwl:hasDbXref "PMID:25613349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002172 ; owl:annotatedTarget "A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002172 ; owl:annotatedTarget "Balance impairment" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002174 ; owl:annotatedTarget "A type of tremors that is triggered by holding a limb in a fixed position." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002174 ; owl:annotatedTarget "Tremor, postural" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002176 ; owl:annotatedTarget "External mechanical compression of the spinal cord." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002176 ; owl:annotatedTarget "Pressure on spinal cord" . [] oboInOwl:hasDbXref "PMID:29972427" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0002179 ; owl:annotatedTarget "Severe hyperextension and spasticity in which an individual's head, neck and spinal column arch posteriorly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002180 ; owl:annotatedTarget "Progressive loss of neural cells and tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002180 ; owl:annotatedTarget "Ongoing loss of nerve cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "ortho-methoxyphenol" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Beilstein:4122932" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002181 ; owl:annotatedTarget "Abnormal accumulation of fluid in the brain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002181 ; owl:annotatedTarget "Brain swelling" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002181 ; owl:annotatedTarget "Cerebral oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002181 ; owl:annotatedTarget "Swelling of brain" . [] oboInOwl:hasDbXref , , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002183 ; owl:annotatedTarget "Fear of loud sounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002185 ; owl:annotatedTarget "Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form." . [] oboInOwl:hasDbXref , "PMID:34033988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002186 ; owl:annotatedTarget "A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002187 ; owl:annotatedTarget "Profound mental retardation is defined as an intelligence quotient (IQ) below 20." . [] oboInOwl:hasDbXref "https://www.merckmanuals.com/home/children-s-health-issues/learning-and-developmental-disorders/intellectual-disability" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002187 ; owl:annotatedTarget "IQ less than 20" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "CAS:13870-90-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002188 ; owl:annotatedTarget "Delayed myelination in the central nervous system." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "CAS:13870-90-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002190 ; owl:annotatedTarget "A cyst occurring within the choroid plexus within a cerebral ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002191 ; owl:annotatedTarget "Spasticity that increases in degree with time." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Gmelin:439994" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002193 ; owl:annotatedTarget "Individuals with Pseudobulbar signs often also demonstrate abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002193 ; owl:annotatedTarget "Pseudobulbar behavioural symptoms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002194 ; owl:annotatedTarget "A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002194 ; owl:annotatedTarget "Delayed motor skills" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "PMID:11792214" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002195 ; owl:annotatedTarget "Defective development of the vermis of cerebellum." . [] oboInOwl:hasDbXref , "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064", "PMID:6790275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Generalised onset seizure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Generalised seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Generalised-onset seizure" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Generalized seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Generalized-onset seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002197 ; owl:annotatedTarget "Primary generalised seizure" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "PMID:12093296" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002198 ; owl:annotatedTarget "An abnormal dilatation of the fourth cerebral ventricle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002199 ; owl:annotatedTarget "Low calcium seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002200 ; owl:annotatedTarget "Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "PMID:17011224" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002202 ; owl:annotatedTarget "The presence of an excessive amount of fluid in the pleural cavity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002202 ; owl:annotatedTarget "Fluid around lungs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002203 ; owl:annotatedTarget "Inability to move the muscles of respiration." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002204 ; owl:annotatedTarget "Blood clot in artery of lung" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Reaxys:4122932" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "Frequent respiratory infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "Multiple respiratory infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "Recurrent respiratory infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "Susceptibility to respiratory infections" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002205 ; owl:annotatedTarget "respiratory infections, recurrent" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002206 ; owl:annotatedTarget "Replacement of normal lung tissues by fibroblasts and collagen." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Cobamamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002208 ; owl:annotatedTarget "Hair shafts are rough in texture." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002208 ; owl:annotatedTarget "Rough hair texture" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002208 ; owl:annotatedTarget "Coarse hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002208 ; owl:annotatedTarget "Coarse hair texture" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_134251 ; owl:annotatedTarget "ortho-methoxyphenols" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "(5,6-Dimethylbenzimidazolyl)cobamide coenzyme" . [] oboInOwl:hasDbXref "PMID:19125436", "PMID:28061825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Decreased number of hairs per unit area of skin of the scalp." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Reduced amount of scalp hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Reduced/lack of hair on scalp" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Sparse scalp hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Thinning scalp hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002209 ; owl:annotatedTarget "Thin scalp hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002211 ; owl:annotatedTarget "A triangular depigmented region of white hairs located in the anterior midline of the scalp." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002211 ; owl:annotatedTarget "Poliosis of anterior hair" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "(5,6-dimethylbenzimidazolyl)cobamide coenzyme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002211 ; owl:annotatedTarget "Poliosis of forelock hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002211 ; owl:annotatedTarget "White part of hair above forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002212 ; owl:annotatedTarget "Curly hair" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-Deoxy-5'-adenosyl vitamin B12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Hair that is fine or thin to the touch." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Fine hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Fine hair shaft" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Fine hair texture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Thin hair shaft" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002213 ; owl:annotatedTarget "Thin hair texture" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-Deoxy-5'-adenosylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002215 ; owl:annotatedTarget "Reduced number or density of axillary hair." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002215 ; owl:annotatedTarget "Limited armpit hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002215 ; owl:annotatedTarget "Little underarm hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Development of gray hair at a younger than normal age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Early graying" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Early greying" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature graying" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature graying of hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature greying" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature greying of hair" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-deoxyadenosyl vitamin B12" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature hair graying" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature hair greying" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature graying of the hair" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002216 ; owl:annotatedTarget "Premature greying of the hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002217 ; owl:annotatedTarget "Hair whose growth is slower than normal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002217 ; owl:annotatedTarget "Slow growing hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002217 ; owl:annotatedTarget "Slow rate of hair growth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002217 ; owl:annotatedTarget "Slow speed of hair growth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002217 ; owl:annotatedTarget "Slow-growing hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002218 ; owl:annotatedTarget "Hypopigmented hair that appears silver-gray." . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002218 ; owl:annotatedTarget "Silver-gray hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002218 ; owl:annotatedTarget "Silver-gray hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002218 ; owl:annotatedTarget "Silver-gray hair colour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002218 ; owl:annotatedTarget "Silvery-gray hair" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5'-deoxyadenosylcobalamin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002219 ; owl:annotatedTarget "Increased facial hair growth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002221 ; owl:annotatedTarget "Absence of axillary hair." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Absence of the eyebrow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Absent eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Failure of development of eyebrows" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Agenesis of eyebrows" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Aplasia of eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Loss of eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002223 ; owl:annotatedTarget "Missing eyebrows" . [] oboInOwl:hasDbXref "PMID:20464096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "Nappy hair texture" . [] a owl:Axiom ; rdfs:label "Wooly hair" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "MEDDRA:10048017" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "Kinked hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "Afro-textured hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002224 ; owl:annotatedTarget "Kinky hair texture" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_13643 ; owl:annotatedTarget "glycols" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Adenosylcob(III)alamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002225 ; owl:annotatedTarget "Reduced number or density of pubic hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002225 ; owl:annotatedTarget "Decreased sexual hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002225 ; owl:annotatedTarget "Sparse pubic hair" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Adenosylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002226 ; owl:annotatedTarget "White color (lack of pigmentation) of the eyebrow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002226 ; owl:annotatedTarget "Pale eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002226 ; owl:annotatedTarget "White eyebrow" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "AdoCbl" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002226 ; owl:annotatedTarget "Grey eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002226 ; owl:annotatedTarget "Blonde eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002227 ; owl:annotatedTarget "White color (lack of pigmentation) of the eyelashes." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Calomide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002227 ; owl:annotatedTarget "Blonde eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002227 ; owl:annotatedTarget "Pale eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002227 ; owl:annotatedTarget "White eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002227 ; owl:annotatedTarget "Grey eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002230 ; owl:annotatedTarget "Abnormally increased hair growth over much of the entire body." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002230 ; owl:annotatedTarget "Excessive hairiness over body" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002230 ; owl:annotatedTarget "Generalised hirsutism" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Calomide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002231 ; owl:annotatedTarget "Sparseness of the body hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002231 ; owl:annotatedTarget "Sparse body hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002232 ; owl:annotatedTarget "Patchy baldness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002234 ; owl:annotatedTarget "Loss of scalp hair at an earlier than normal age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002234 ; owl:annotatedTarget "Early balding" . [] oboInOwl:hasDbXref , "PMID:8274794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002235 ; owl:annotatedTarget "A characteristic triangular, kidney- or heat-shaped diameter of hair shafts with typical longitudinal canalicular deformation as observable by scanning electron microscopy." . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Upward and/or sideward growth of anterior hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Cowlick" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Frontal Cowlick" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Frontal upsweep of hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Upswept frontal hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Upswept frontal hair pattern" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002236 ; owl:annotatedTarget "Upswept frontal hairline" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Cobalamin coenzyme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002239 ; owl:annotatedTarget "Hemorrhage affecting the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002239 ; owl:annotatedTarget "GI haemorrhage" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Coenzyme B12" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002239 ; owl:annotatedTarget "GI hemorrhage" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002239 ; owl:annotatedTarget "Gastrointestinal bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002239 ; owl:annotatedTarget "Gastrointestinal haemorrhage" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "DBC coenzyme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002240 ; owl:annotatedTarget "Abnormally increased size of the liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002240 ; owl:annotatedTarget "Enlarged liver" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002242 ; owl:annotatedTarget "An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "DMBC coenzyme" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002242 ; owl:annotatedTarget "Abnormality of the intestine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002243 ; owl:annotatedTarget "Abnormal loss of protein from the digestive tract related to excessive leakage of plasma proteins into the lumen of the gastrointestinal tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002244 ; owl:annotatedTarget "A structural abnormality of the small intestine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13643 ; owl:annotatedTarget "Glykol" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Deoxyadenosylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002245 ; owl:annotatedTarget "Meckel's diverticulum is a congenital diverticulum located in the distal ileum." . [] a owl:Axiom ; rdfs:label "Meckel's diverticulum" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002245 ; owl:annotatedTarget "MEDDRA:10027055" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002246 ; owl:annotatedTarget "An abnormality of the duodenum, i.e., the first section of the small intestine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Dibencozide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002247 ; owl:annotatedTarget "A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum." . [] a owl:Axiom ; rdfs:label "Duodenal atresia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002247 ; owl:annotatedTarget "MEDDRA:10013812" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002247 ; owl:annotatedTarget "Absence or narrowing of first part of small bowel" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Funacomide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002248 ; owl:annotatedTarget "The vomiting of blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002248 ; owl:annotatedTarget "Vomitting blood" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "Vitamin B12 coenzyme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002249 ; owl:annotatedTarget "The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002249 ; owl:annotatedTarget "Black faeces" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002249 ; owl:annotatedTarget "Black feces" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "adenosylcob(III)alamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002250 ; owl:annotatedTarget "Any abnormality of the large intestine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002250 ; owl:annotatedTarget "Abnormality of the large intestine" . [] oboInOwl:hasDbXref , "PMID:17965226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002251 ; owl:annotatedTarget "An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon." . [] a owl:Axiom ; rdfs:label "Megacolon" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002251 ; owl:annotatedTarget "MEDDRA:10027110" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002251 ; owl:annotatedTarget "Enlarged colon lacking nerve cells" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "adenosylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002253 ; owl:annotatedTarget "The presence of multiple diverticula of the colon." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme" . [] a owl:Axiom ; rdfs:label "Colonic diverticulosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002253 ; owl:annotatedTarget "MEDDRA:10009993" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002254 ; owl:annotatedTarget "Episodic diarrhoea" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002254 ; owl:annotatedTarget "Intermittent diarrhoea" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamamid" . [] a owl:Axiom ; rdfs:label "Diverticula of small intestine" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002256 ; owl:annotatedTarget "MEDDRA:10013533" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002257 ; owl:annotatedTarget "Chronic inflammation of the nasal mucosa." . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002263 ; owl:annotatedTarget "More pronounced paramedian peaks and median notch of the Cupid's bow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002263 ; owl:annotatedTarget "Cupid bow upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002263 ; owl:annotatedTarget "Cupid-bow shaped upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002263 ; owl:annotatedTarget "Exaggerated cupid's bow" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamamida" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002263 ; owl:annotatedTarget "Prominent cupid-bow of upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002265 ; owl:annotatedTarget "Large fleshy ears" . [] oboInOwl:hasDbXref , "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002266 ; owl:annotatedTarget "A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002266 ; owl:annotatedTarget "Focal clonic seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002266 ; owl:annotatedTarget "Localised clonic seizure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002266 ; owl:annotatedTarget "Localized clonic seizure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002266 ; owl:annotatedTarget "Partial clonic seizure" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002267 ; owl:annotatedTarget "An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002268 ; owl:annotatedTarget "A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136849 ; owl:annotatedTarget "a 3-oxo-Delta4-steroid group" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002269 ; owl:annotatedTarget "An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamamidum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002270 ; owl:annotatedTarget "An abnormality of the autonomic nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002273 ; owl:annotatedTarget "Weakness of all four limbs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002275 ; owl:annotatedTarget "Poor motor coordination" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002277 ; owl:annotatedTarget "An abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002277 ; owl:annotatedTarget "Oculosympathetic palsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002280 ; owl:annotatedTarget "Increase in size of the cisterna magna, one of three principal openings in the subarachnoid space between the arachnoid and pia mater, located between the cerebellum and the dorsal surface of the medulla oblongata." . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "cobamide coenzyme" . [] oboInOwl:hasDbXref , , "PMID:22427329", "PMID:25180909", "PMID:7524438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002282 ; owl:annotatedTarget "Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002282 ; owl:annotatedTarget "Gray matter heterotopias" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002282 ; owl:annotatedTarget "Grey matter heterotopia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002282 ; owl:annotatedTarget "Grey matter heterotopias" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002282 ; owl:annotatedTarget "Heterotopias" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_18408 ; owl:annotatedTarget "coenzyme B-12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002283 ; owl:annotatedTarget "Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002283 ; owl:annotatedTarget "Generalised brain atrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002283 ; owl:annotatedTarget "Generalised brain degeneration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002283 ; owl:annotatedTarget "Generalised cerebral atrophy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002283 ; owl:annotatedTarget "Generalized brain degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "A lesser degree of hair pigmentation than would otherwise be expected." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Blond hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Fair hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Fair hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Fair hair colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Flaxen hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Flaxen hair colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Light colored hair" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Light coloured hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Sandy hair color" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_189846 ; owl:annotatedTarget "a dicarboxylic fatty acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Sandy hair colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Straw colored hair" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Straw coloured hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002286 ; owl:annotatedTarget "Towhead (hair color)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002287 ; owl:annotatedTarget "Progressive loss of hair." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002289 ; owl:annotatedTarget "Loss of all hair on the entire body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002290 ; owl:annotatedTarget "Circumscribed depigmentation of the hair of the head or the eyelashes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002290 ; owl:annotatedTarget "Patch of white hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002290 ; owl:annotatedTarget "White patch" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002292 ; owl:annotatedTarget "Absence of hair in the anterior midline and/or parietal areas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002292 ; owl:annotatedTarget "Male pattern baldness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002292 ; owl:annotatedTarget "Frontal balding" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002293 ; owl:annotatedTarget "Absence of scalp hair" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_191220 ; owl:annotatedTarget "(2S)-methylsuccinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002293 ; owl:annotatedTarget "Baldness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002293 ; owl:annotatedTarget "Missing scalp hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002293 ; owl:annotatedTarget "Pathologic hair loss from scalp" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002293 ; owl:annotatedTarget "Scalp hair loss" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-keto steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002296 ; owl:annotatedTarget "Progressively reduced or lacking hair growth." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_136859 ; owl:annotatedTarget "PMID:26449612" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-keto steroids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Ginger hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Ginger hair colour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Red hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Red hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Red hair colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002297 ; owl:annotatedTarget "Red head (hair color)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-ketosteroid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002298 ; owl:annotatedTarget "Absent hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Fragile, easily breakable hair, i.e., with reduced tensile strength." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Easily breakable hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Fractured hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Fragile hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Reduced tensile strength of hair" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-ketosteroids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002299 ; owl:annotatedTarget "Brittle hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002300 ; owl:annotatedTarget "Inability to speak" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002300 ; owl:annotatedTarget "Muteness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-oxo steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002301 ; owl:annotatedTarget "Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002301 ; owl:annotatedTarget "Paralysis on one side of body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002304 ; owl:annotatedTarget "Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-oxosteroid" . [] oboInOwl:hasDbXref , "PMID:20589866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002305 ; owl:annotatedTarget "A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002305 ; owl:annotatedTarget "Involuntary writhing movements in fingers, hands, toes, and feet" . [] oboInOwl:hasDbXref , "PMID:15202698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002307 ; owl:annotatedTarget "Habitual flow of saliva out of the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002307 ; owl:annotatedTarget "Dribbling" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002307 ; owl:annotatedTarget "Drooling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002307 ; owl:annotatedTarget "Sialorrhea" . [] oboInOwl:hasDbXref , "PMID:28613730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002308 ; owl:annotatedTarget "Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002311 ; owl:annotatedTarget "Difficulties in coordination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002311 ; owl:annotatedTarget "Incoordination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002311 ; owl:annotatedTarget "Incoordination of limb movements" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "17-oxosteroids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002311 ; owl:annotatedTarget "Limb incoordination" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002312 ; owl:annotatedTarget "Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002312 ; owl:annotatedTarget "Clumsiness" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_19168 ; owl:annotatedTarget "a 17-oxo steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002314 ; owl:annotatedTarget "Deterioration of the tissues of the lateral corticospinal tracts." . [] oboInOwl:hasDbXref , "PMID:15304572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002315 ; owl:annotatedTarget "Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002315 ; owl:annotatedTarget "Headache" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002315 ; owl:annotatedTarget "Headaches" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002317 ; owl:annotatedTarget "Unsteady walk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002321 ; owl:annotatedTarget "An abnormal sensation of spinning while the body is actually stationary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002321 ; owl:annotatedTarget "Dizzy spell" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002321 ; owl:annotatedTarget "Dizziness" . [] oboInOwl:hasDbXref , "PMID:22675666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002322 ; owl:annotatedTarget "A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002322 ; owl:annotatedTarget "Resting tremor" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_194548 ; owl:annotatedTarget "4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002322 ; owl:annotatedTarget "Tremor at rest" . [] oboInOwl:hasDbXref "PMID:31424828", "PMID:32706613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002323 ; owl:annotatedTarget "Anencephaly is a developmental anomaly characterized by a fetus that has no calvarium, with a lack of most or all of the fetus' brain tissue. Anencephaly belongs to a collective group known as neural tube defects (NTD) and is a result of the neural tube failing to close in its rostral end during fetal development." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002323 ; owl:annotatedTarget "Foetal anencephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002324 ; owl:annotatedTarget "A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002324 ; owl:annotatedTarget "Hydrancephaly" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002326 ; owl:annotatedTarget "Mini stroke" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002326 ; owl:annotatedTarget "TIA" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002326 ; owl:annotatedTarget "Transient ischaemic attack" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002326 ; owl:annotatedTarget "Transient ischaemic attacks" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002329 ; owl:annotatedTarget "Excessive daytime sleepiness." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002329 ; owl:annotatedTarget "Drowsiness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002329 ; owl:annotatedTarget "Sleepy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002330 ; owl:annotatedTarget "Attacks of disabling daytime drowsiness and low alertness." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002331 ; owl:annotatedTarget "Repeated episodes of headache with rapid onset, reaching a peak within minutes and of short duration (less than one hour) with pain that is throbbing, pulsating, or bursting in quality." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002333 ; owl:annotatedTarget "Loss of previously present motor (i.e., movement) abilities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002333 ; owl:annotatedTarget "Progressive degeneration of movement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136859 ; owl:annotatedTarget "pro-agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002334 ; owl:annotatedTarget "An anomaly of the vermis of cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002335 ; owl:annotatedTarget "Congenital absence of the vermis of cerebellum." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "Beilstein:773861" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002339 ; owl:annotatedTarget "Any structural abnormality of the caudate nucleus." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "CAS:300-85-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002340 ; owl:annotatedTarget "Caudate degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002341 ; owl:annotatedTarget "Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002342 ; owl:annotatedTarget "Moderate mental retardation is defined as an intelligence quotient (IQ) in the range of 35-49." . [] oboInOwl:hasDbXref "https://www.merckmanuals.com/home/children-s-health-issues/learning-and-developmental-disorders/intellectual-disability" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002342 ; owl:annotatedTarget "IQ between 34 and 49" . [] oboInOwl:hasDbXref , "eMedicine:1135286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002343 ; owl:annotatedTarget "A form of hydrocephalus characterized by enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure upon lumbar puncture." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002344 ; owl:annotatedTarget "Worsening neurological symptoms" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01050005" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002345 ; owl:annotatedTarget "A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "PMID:10855969" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002346 ; owl:annotatedTarget "An unintentional, oscillating to-and-fro muscle movement affecting head movement." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002346 ; owl:annotatedTarget "Head tremor" . [] oboInOwl:hasDbXref , , "PMID:28276060", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002349 ; owl:annotatedTarget "A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002349 ; owl:annotatedTarget "Focal aware seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002349 ; owl:annotatedTarget "Focal seizures without impairment of consciousness or awareness" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002349 ; owl:annotatedTarget "Simple partial seizures" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002350 ; owl:annotatedTarget "Cerebellar cysts" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "PMID:17579249" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002352 ; owl:annotatedTarget "This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002353 ; owl:annotatedTarget "Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002353 ; owl:annotatedTarget "Abnormal EEG" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002353 ; owl:annotatedTarget "EEG abnormalities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "PMID:6061736" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "Forgetfulness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "Memory impairment" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "Memory loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "Memory problems" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002354 ; owl:annotatedTarget "Poor memory" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "Reaxys:773861" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002355 ; owl:annotatedTarget "Reduced ability to walk (ambulate)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002355 ; owl:annotatedTarget "Difficulty in walking" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002355 ; owl:annotatedTarget "Difficulty walking" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002356 ; owl:annotatedTarget "A focal dystonia of the fingers, hand, and/or forearm that appears when the affected person attempts to do a task that requires fine motor movements such as writing or playing a musical instrument." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002356 ; owl:annotatedTarget "Writer's cramp" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002359 ; owl:annotatedTarget "Frequent falls" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "3-hydroxybutanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002360 ; owl:annotatedTarget "An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002360 ; owl:annotatedTarget "Difficulty sleeping" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002360 ; owl:annotatedTarget "Sleep disturbances" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002360 ; owl:annotatedTarget "Trouble sleeping" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002361 ; owl:annotatedTarget "Loss of previously present mental and motor abilities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002362 ; owl:annotatedTarget "Shuffled walk" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136859 ; owl:annotatedTarget "proagent" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "(1)-3-Hydroxybutyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002363 ; owl:annotatedTarget "An anomaly of the brainstem." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002363 ; owl:annotatedTarget "Abnormal shape of brainstem" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "3 HBA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002365 ; owl:annotatedTarget "Underdevelopment of the brainstem." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002365 ; owl:annotatedTarget "Small brainstem" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002365 ; owl:annotatedTarget "Underdeveloped brainstem" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002366 ; owl:annotatedTarget "Any structural anomaly of the lower motor neuron." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002367 ; owl:annotatedTarget "Visual hallucinations" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "3-Hydroxybuttersaeure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002370 ; owl:annotatedTarget "Poor coordination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002371 ; owl:annotatedTarget "Loss of speech" . [] oboInOwl:hasDbXref , "PMID:10353950", "PMID:19125841", "PMID:30078767", "PMID:6779259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002373 ; owl:annotatedTarget "A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002373 ; owl:annotatedTarget "Febrile seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002373 ; owl:annotatedTarget "Fever induced seizures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002374 ; owl:annotatedTarget "Diminished movement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "3-OH-butyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002375 ; owl:annotatedTarget "Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002375 ; owl:annotatedTarget "Decreased muscle movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002375 ; owl:annotatedTarget "Decreased spontaneous movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002375 ; owl:annotatedTarget "Decreased spontaneous movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002376 ; owl:annotatedTarget "Loss of developmental skills, as manifested by loss of developmental milestones." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002376 ; owl:annotatedTarget "Loss of developmental milestones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002376 ; owl:annotatedTarget "Mental deterioration in childhood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "BHBA" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "DL-beta-Hydroxybutyric acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002378 ; owl:annotatedTarget "Hand tremor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002378 ; owl:annotatedTarget "Tremor of hand" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002378 ; owl:annotatedTarget "Tremor of hands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002378 ; owl:annotatedTarget "tremors in hands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002380 ; owl:annotatedTarget "Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units." . [] oboInOwl:hasDbXref , "https://www.nlm.nih.gov/medlineplus/ency/article/003296.htm" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002380 ; owl:annotatedTarget "Muscle twitch" . [] oboInOwl:hasDbXref "PMID:27384070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002381 ; owl:annotatedTarget "An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002381 ; owl:annotatedTarget "Difficulty finding words" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002381 ; owl:annotatedTarget "Losing words" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "beta-Hydroxy-n-butyric acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002381 ; owl:annotatedTarget "Loss of words" . [] oboInOwl:hasDbXref "PMID:24365426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002383 ; owl:annotatedTarget "A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002383 ; owl:annotatedTarget "Brain inflammation" . [] oboInOwl:hasDbXref , "PMID:28276062", "PMID:28276064", "PMID:9738682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002384 ; owl:annotatedTarget "Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002384 ; owl:annotatedTarget "Focal impaired awareness seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002384 ; owl:annotatedTarget "Focal seizures with impairment of consciousness or awareness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002385 ; owl:annotatedTarget "Weakness or partial paralysis in the lower limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002385 ; owl:annotatedTarget "Partial paralysis of legs" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "beta-Hydroxybuttersaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002389 ; owl:annotatedTarget "If the two laminae of the septum pellucidum are not fused then a fluid-filled space or cavum is present. The cavum septum pellucidum is present at birth but usually obliterates by the age of 3 to 6 months. It is up to 1cm in width and the walls are parallel. It is an enclosed space and is not part of the ventricular system or connected with the subarachnoid space." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002392 ; owl:annotatedTarget "The presence of complexes of repetitive spikes and waves in EEG." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "beta-hydroxy-n-butyric acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "beta-hydroxybutanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002395 ; owl:annotatedTarget "Overactive lower leg reflex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002396 ; owl:annotatedTarget "A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched)." . [] oboInOwl:hasDbXref "PMID:22715346", "PMID:23907585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002401 ; owl:annotatedTarget "No consensus exists on what a stroke-like episode is, but these episodes can be functionally defined as a new neurological deficit, occurring with or without the context of seizures, which last longer than 24 hours." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136859 ; owl:annotatedTarget "proagents" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20067 ; owl:annotatedTarget "beta-hydroxybutyric acid" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002401 ; owl:annotatedTarget "Stroke-like episodes" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002401 ; owl:annotatedTarget "Strokelike episodes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002403 ; owl:annotatedTarget "The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002404 ; owl:annotatedTarget "Increased width of the superior cerebellar peduncle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002406 ; owl:annotatedTarget "A type of dysmetria involving the limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002406 ; owl:annotatedTarget "Uncoordinated limb movement" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002408 ; owl:annotatedTarget "Cerebral AV malformation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002410 ; owl:annotatedTarget "Stenosis of the cerebral aqueduct (also known as the mesencephalic duct, aqueductus mesencephali, or aqueduct of Sylvius), which connects the third cerebral ventricle in the diencephalon to the fourth ventricle, which is between the pons and cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002410 ; owl:annotatedTarget "Narrowing of aqueduct of Sylvius" . [] oboInOwl:hasDbXref "PMID:21501741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002411 ; owl:annotatedTarget "Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002414 ; owl:annotatedTarget "Incomplete closure of the embryonic neural tube, whereby some vertebral arches remain unfused and open. The mildest form is spina bifida occulta, followed by meningocele and meningomyelocele." . [] oboInOwl:hasDbXref , "http://www.mayoclinic.org/diseases-conditions/spina-bifida/basics/definition/con-20035356?utm_source=google&utm_medium=abstract&utm_content=spina-bifida&utm_campaign=knowledge-panel" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002414 ; owl:annotatedTarget "Split spine" . [] oboInOwl:hasDbXref , "PMID:30620693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002415 ; owl:annotatedTarget "Leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes. Symmetric white matter involvement at MRI is a typical finding in patients with leukodystrophies." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/leukodystrophy" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002415 ; owl:annotatedTarget "Degeneration of white matter of brain" . [] oboInOwl:hasDbXref , "PMID:12423490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002416 ; owl:annotatedTarget "Cerebral cysts, usually located in the wall of the caudate nucleus or in the caudothalamic groove. They are found in up to 5.2% of all neonates, using transfontanellar ultrasound in the first days of life." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "Beilstein:2213227" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002418 ; owl:annotatedTarget "An abnormality of the midbrain, which has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002418 ; owl:annotatedTarget "Abnormal shape of midbrain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002418 ; owl:annotatedTarget "Abnormality of the midbrain" . [] oboInOwl:hasDbXref , "PMID:14657304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002419 ; owl:annotatedTarget "An abnormal appearance of the midbrain in axial magnetic resonance imaging in which the elongated superior cerebellar peduncles give the midbrain an appearance reminiscent of a molar or wisdom tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002421 ; owl:annotatedTarget "Difficulty to maintain correct position of the head while standing or sitting." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002421 ; owl:annotatedTarget "Poor head control" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002425 ; owl:annotatedTarget "A defect in the motor ability that enables speech." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "CAS:55-10-7" . [] oboInOwl:hasDbXref , "http://dictionary.reference.com/browse/anarthria" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002425 ; owl:annotatedTarget "Loss of articulate speech" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002427 ; owl:annotatedTarget "Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/aphasia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002427 ; owl:annotatedTarget "Broca's aphasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002427 ; owl:annotatedTarget "Loss of expressive speech" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/aphasia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002427 ; owl:annotatedTarget "Motor aphasia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002427 ; owl:annotatedTarget "Non-fluent aphasia" . [] oboInOwl:hasDbXref , "PMID:32965845" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002435 ; owl:annotatedTarget "Protrusion of the meninges through a defect of the skull or vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002436 ; owl:annotatedTarget "A herniation of meninges through a congenital bone defect in the skull in the occipital region." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "CAS:55-10-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002442 ; owl:annotatedTarget "A specific learning disability involving mathematics and arithmetic." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002442 ; owl:annotatedTarget "Difficulty making arithmetical calculations" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "PMID:13756637" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002444 ; owl:annotatedTarget "The presence of a hamartoma of the hypothalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002445 ; owl:annotatedTarget "Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "PMID:23112240" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002445 ; owl:annotatedTarget "Paralysis of all four limbs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "PMID:23399766" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002446 ; owl:annotatedTarget "Proliferation of astrocytes in the area of a lesion of the central nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002446 ; owl:annotatedTarget "Increase in astrocyte number" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002448 ; owl:annotatedTarget "Progressive brain disease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136889 ; owl:annotatedTarget "5beta steroids" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "PMID:23830883" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002450 ; owl:annotatedTarget "Abnormal shape of motor neuron" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "PMID:24327171" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002451 ; owl:annotatedTarget "A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the limbs." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "Reaxys:2213227" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002453 ; owl:annotatedTarget "An abnormality of the globus pallidus." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid" . [] oboInOwl:hasDbXref , "PMID:11110959", "PMID:19881070", "PMID:29371252" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002454 ; owl:annotatedTarget "The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002457 ; owl:annotatedTarget "Abnormal head movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002460 ; owl:annotatedTarget "Reduced strength of the musculature of the distal extremities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002460 ; owl:annotatedTarget "Weakness of outermost muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002460 ; owl:annotatedTarget "Distal limb muscle weakness due to peripheral neuropathy" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "Vanillylmandelic acid" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002463 ; owl:annotatedTarget "Language disorder" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002464 ; owl:annotatedTarget "A type of dysarthria related to bilateral damage of the upper motor neuron tracts of the pyramidal and extra- pyramidal tracts. Speech of affected individuals is slow, effortful, and has a harsh vocal quality." . [] oboInOwl:hasDbXref , "http://medical-dictionary.thefreedictionary.com/spastic+dysarthria" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002464 ; owl:annotatedTarget "Rigid dysarthria" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002465 ; owl:annotatedTarget "Problems speaking" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "3-methoxy-4-hydroxymandelic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002465 ; owl:annotatedTarget "Poor speech" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002465 ; owl:annotatedTarget "Difficulty speaking" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002472 ; owl:annotatedTarget "Reduced size of the cerebral cortex." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "Vanilmandelic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002474 ; owl:annotatedTarget "A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002474 ; owl:annotatedTarget "Communication delay" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002475 ; owl:annotatedTarget "Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002475 ; owl:annotatedTarget "Spina bifida cystica" . [] oboInOwl:hasDbXref "PMID:12700289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002476 ; owl:annotatedTarget "The primitive reflexes are a group of behavioural motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20106 ; owl:annotatedTarget "hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002480 ; owl:annotatedTarget "Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002486 ; owl:annotatedTarget "An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002486 ; owl:annotatedTarget "Delayed relaxation of muscle fibres after contraction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002487 ; owl:annotatedTarget "Motor hyperactivity with excessive movement of muscles of the body as a whole." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002487 ; owl:annotatedTarget "Muscle spasms" . [] oboInOwl:hasDbXref "NCIT:C9300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002488 ; owl:annotatedTarget "A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002488 ; owl:annotatedTarget "Acute blood cancer" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002488 ; owl:annotatedTarget "Acute leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002490 ; owl:annotatedTarget "Increased concentration of lactate in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136889 ; owl:annotatedTarget "5beta-steroid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002491 ; owl:annotatedTarget "Increased stiffness of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002491 ; owl:annotatedTarget "Increased tone of facial muscles" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "PMID:21988268" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002492 ; owl:annotatedTarget "Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "PMID:24563386" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002493 ; owl:annotatedTarget "A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "PMID:24695516" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002494 ; owl:annotatedTarget "Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "Decreased vibration sense" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "Decreased vibratory sense" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "Diminished vibratory sense" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "PMID:436278" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "Impaired vibratory sensation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002495 ; owl:annotatedTarget "Impaired vibratory sense" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002500 ; owl:annotatedTarget "An abnormality of the cerebral white matter." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "4-hydroxyproline" . [] oboInOwl:hasDbXref "PMID:3800716" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002500 ; owl:annotatedTarget "Leukoaraiosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002500 ; owl:annotatedTarget "Cortical white matter abnormalities seen on MRI" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002504 ; owl:annotatedTarget "Deposition of calcium salts within small blood vessels of the brain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20392 ; owl:annotatedTarget "4Hyp" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002505 ; owl:annotatedTarget "Loss of ability to walk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002506 ; owl:annotatedTarget "Diffuse unlocalised atrophy affecting the cerebrum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_20612 ; owl:annotatedTarget "5-methyltetrahydrofolates" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GC_HPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002507 ; owl:annotatedTarget "A type of holoprosencephaly in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002508 ; owl:annotatedTarget "A developmental structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20664 ; owl:annotatedTarget "Beilstein:2048472" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002509 ; owl:annotatedTarget "Increased muscle tone of arm or leg" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002510 ; owl:annotatedTarget "Spastic paralysis affecting all four limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002511 ; owl:annotatedTarget "A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002511 ; owl:annotatedTarget "Alzheimer disease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002511 ; owl:annotatedTarget "Late-onset form of familial Alzheimer disease" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20664 ; owl:annotatedTarget "5beta-cholane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002514 ; owl:annotatedTarget "The presence of calcium deposition within brain structures." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002514 ; owl:annotatedTarget "Abnormal deposits of calcium in the brain" . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002515 ; owl:annotatedTarget "Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_136889 ; owl:annotatedTarget "5beta-steroids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20702 ; owl:annotatedTarget "2-aminopurines" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002515 ; owl:annotatedTarget "Waddling gait" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002515 ; owl:annotatedTarget "Waddling walk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002516 ; owl:annotatedTarget "An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002516 ; owl:annotatedTarget "Rise in pressure inside skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002518 ; owl:annotatedTarget "Periventricular white matter abnormalities" . [] oboInOwl:hasDbXref "PMID:27358492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002519 ; owl:annotatedTarget "Fleeting perceptual experiences that occur during the transition from wakefulness to sleep." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002521 ; owl:annotatedTarget "Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20706 ; owl:annotatedTarget "PMID:1646334" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002522 ; owl:annotatedTarget "Inability to elicit tendon reflexes in the lower limbs." . [] oboInOwl:hasDbXref , "PMID:21931493", "PMID:22249574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002524 ; owl:annotatedTarget "A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20706 ; owl:annotatedTarget "PMID:18524423" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002526 ; owl:annotatedTarget "Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002527 ; owl:annotatedTarget "Falls" . [] oboInOwl:hasDbXref "PMID:22073234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002528 ; owl:annotatedTarget "Electron-dense granules within double membrane-bound cytoplasmic vacuoles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_20706 ; owl:annotatedTarget "PMID:7342604" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_20706 ; owl:annotatedTarget "6-aminopurines" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002529 ; owl:annotatedTarget "Loss of brain cells" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002529 ; owl:annotatedTarget "Neuronal loss in CNS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002530 ; owl:annotatedTarget "A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002533 ; owl:annotatedTarget "Involuntary flexion or extension of the arms and legs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_21619 ; owl:annotatedTarget "N-acetylneuraminate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002536 ; owl:annotatedTarget "An abnormality of the gyri (i.e., the ridges) of the cerebral cortex of the brain." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002536 ; owl:annotatedTarget "Gyral disorganisation" . [] oboInOwl:hasDbXref , "PMID:31373394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002538 ; owl:annotatedTarget "Any structural abnormality of the cerebral cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002539 ; owl:annotatedTarget "The presence of developmental dysplasia of the cerebral cortex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_21663 ; owl:annotatedTarget "N-acylneuraminate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002540 ; owl:annotatedTarget "Incapability to ambulate." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002540 ; owl:annotatedTarget "Inability to walk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002542 ; owl:annotatedTarget "Neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus." . [] oboInOwl:hasDbXref , "PMID:17917462" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002544 ; owl:annotatedTarget "A form of torticollis in which the head is drawn back, either due to a permanent contractures of neck extensor muscles, or to a spasmodic contracture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002545 ; owl:annotatedTarget "Patchy loss of myelin from nerve fibers in the central nervous system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002546 ; owl:annotatedTarget "Incomprehensible speech" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002548 ; owl:annotatedTarget "Parkinsonism with favourable response to dopaminergic medication" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002548 ; owl:annotatedTarget "Favourable response to levodopa" . [] oboInOwl:hasDbXref "PMID:19646677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002549 ; owl:annotatedTarget "Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_21760 ; owl:annotatedTarget "N-methyl-amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002550 ; owl:annotatedTarget "Absence of facial hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002550 ; owl:annotatedTarget "Absent facial hair" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22221 ; owl:annotatedTarget "acyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002552 ; owl:annotatedTarget "Developmental dysplasia of the hair." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002552 ; owl:annotatedTarget "Generalised trichodysplasia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_137682 ; owl:annotatedTarget "methylhistidines" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22221 ; owl:annotatedTarget "alkanoyl" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Arched eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Broad, arched eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "High, rounded eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "High-arched eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Highly arched eyebrow" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22221 ; owl:annotatedTarget "acyl groups" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Thick, flared eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "Bowed and upward slanting eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002553 ; owl:annotatedTarget "High arched eyebrows" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22221 ; owl:annotatedTarget "alkanoyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002555 ; owl:annotatedTarget "Absence of pubic hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002555 ; owl:annotatedTarget "Absent pubic hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002557 ; owl:annotatedTarget "Underdevelopment of the nipple." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22221 ; owl:annotatedTarget "groupe acyle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002557 ; owl:annotatedTarget "Small nipples" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002558 ; owl:annotatedTarget "Presence of more than two nipples." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002558 ; owl:annotatedTarget "Accessory nipple" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002558 ; owl:annotatedTarget "Increased nipple number" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002558 ; owl:annotatedTarget "Accessory nipples" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002561 ; owl:annotatedTarget "Absent nipple" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22299 ; owl:annotatedTarget "aldonate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002561 ; owl:annotatedTarget "Absent nipples" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002562 ; owl:annotatedTarget "Placement of the nipples at a lower than normal location." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002562 ; owl:annotatedTarget "Low-set nipples" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22299 ; owl:annotatedTarget "aldonates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002563 ; owl:annotatedTarget "Presence of a thickened, fibrotic pericardium that forms a non-compliant shell around the heart, and resulting from chronic inflammation of the pericardium." . [] oboInOwl:hasDbXref , "PMID:12438031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002566 ; owl:annotatedTarget "An abnormality of the intestinal rotation and fixation that normally occurs during the development of the gut. This can lead to volvulus, or twisting of the intestine that causes obstruction and necrosis." . [] a owl:Axiom ; rdfs:label "Intestinal malrotation" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002566 ; owl:annotatedTarget "MEDDRA:10064024" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002566 ; owl:annotatedTarget "Gut malrotation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002570 ; owl:annotatedTarget "Greater than normal amounts of fat in the feces. This is a result of malabsorption of lipids in the small intestine and results in frothy foul-smelling fecal matter that floats." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002570 ; owl:annotatedTarget "Fat in faeces" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002570 ; owl:annotatedTarget "Fat in feces" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002570 ; owl:annotatedTarget "Greasy stools" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002571 ; owl:annotatedTarget "A disorder of esophageal motility characterized by the inability of the lower esophageal sphincter to relax during swallowing and by inadequate or lacking peristalsis in the lower half of the body of the esophagus." . [] a owl:Axiom ; rdfs:label "Oesophageal achalasia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002571 ; owl:annotatedTarget "MEDDRA:10030136" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002571 ; owl:annotatedTarget "Achalasia of the oesophagus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002572 ; owl:annotatedTarget "Paroxysmal, recurrent episodes of vomiting." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22301 ; owl:annotatedTarget "aldonic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002572 ; owl:annotatedTarget "Episodic vomiting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002572 ; owl:annotatedTarget "Frequent vomiting" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002573 ; owl:annotatedTarget "The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002573 ; owl:annotatedTarget "Rectal bleeding" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002573 ; owl:annotatedTarget "Recurrent rectal bleeding" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002574 ; owl:annotatedTarget "An intermittent form of abdominal pain." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002574 ; owl:annotatedTarget "Intermittent abdominal pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22301 ; owl:annotatedTarget "aldonic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002575 ; owl:annotatedTarget "An abnormal connection (fistula) between the esophagus and the trachea." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002575 ; owl:annotatedTarget "Abnormal connection between trachea and esophagus" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "alkaline earth metals" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002575 ; owl:annotatedTarget "Abnormal connection between trachea and oesophagus" . [] a owl:Axiom ; rdfs:label "Tracheo-oesophageal fistula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002575 ; owl:annotatedTarget "MEDDRA:10044310" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002576 ; owl:annotatedTarget "An abnormality of the intestine in which part of the intestine invaginates (telescopes) into another part of the intestine." . [] a owl:Axiom ; rdfs:label "Intussusception" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002576 ; owl:annotatedTarget "MEDDRA:10022863" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "Erdalkalimetall" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002577 ; owl:annotatedTarget "An abnormality of the stomach." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002578 ; owl:annotatedTarget "Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "Erdalkalimetalle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002578 ; owl:annotatedTarget "Delayed gastric emptying" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002579 ; owl:annotatedTarget "Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002579 ; owl:annotatedTarget "GI dysmotility" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "alkaline earth metal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002580 ; owl:annotatedTarget "Abnormal twisting of a portion of intestine around itself or around a stalk of mesentery tissue." . [] oboInOwl:hasDbXref , "PMID:21483628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002582 ; owl:annotatedTarget "Atrophic gastritis (AG) is a histopathological entity that is characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "alkaline-earth metal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002583 ; owl:annotatedTarget "Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "alkaline-earth metals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002584 ; owl:annotatedTarget "Bleeding from the intestines." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002584 ; owl:annotatedTarget "Intestinal bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002584 ; owl:annotatedTarget "Intestinal haemorrhage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "metal alcalino-terreux" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002585 ; owl:annotatedTarget "An abnormality of the peritoneum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "metal alcalinoterreo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002586 ; owl:annotatedTarget "Inflammation of the peritoneum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002587 ; owl:annotatedTarget "Vomiting that ejects the gastric contents with great force." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002587 ; owl:annotatedTarget "Projectile vomiting" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "metales alcalinoterreos" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_137982 ; owl:annotatedTarget "a tertiary amine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22313 ; owl:annotatedTarget "metaux alcalino-terreux" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002588 ; owl:annotatedTarget "An erosion of the mucous membrane in a portion of the duodenum." . [] a owl:Axiom ; rdfs:label "Duodenal ulcer" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002588 ; owl:annotatedTarget "MEDDRA:10013836" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "alkali metals" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002589 ; owl:annotatedTarget "GI atresia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "Alkalimetall" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002591 ; owl:annotatedTarget "A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002591 ; owl:annotatedTarget "Voracious appetite" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002591 ; owl:annotatedTarget "Increased appetite" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "Alkalimetalle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002592 ; owl:annotatedTarget "An ulcer, that is, an erosion of an area of the gastric mucous membrane." . [] a owl:Axiom ; rdfs:label "Gastric ulcer" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002592 ; owl:annotatedTarget "MEDDRA:10017822" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002592 ; owl:annotatedTarget "Stomach ulcer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002593 ; owl:annotatedTarget "Angiectasia of lymph vessels (i.e., dilatation of lymphatic vessels) in the intestines." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "alkali metal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002594 ; owl:annotatedTarget "Hypoplasia of the pancreas." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002594 ; owl:annotatedTarget "Underdeveloped pancreas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002595 ; owl:annotatedTarget "Acute obstruction of the intestines preventing passage of the contents of the intestines." . [] a owl:Axiom ; rdfs:label "Ileus" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002595 ; owl:annotatedTarget "MEDDRA:10021328" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002595 ; owl:annotatedTarget "Gastrointestinal atony" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "metal alcalin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002597 ; owl:annotatedTarget "An abnormality of the vasculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002597 ; owl:annotatedTarget "Abnormality of blood vessels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002597 ; owl:annotatedTarget "Abnormality of the vasculature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "metal alcalino" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002597 ; owl:annotatedTarget "Vascular abnormalities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002599 ; owl:annotatedTarget "A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "metales alcalinos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002600 ; owl:annotatedTarget "Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22314 ; owl:annotatedTarget "metaux alcalins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002604 ; owl:annotatedTarget "Telangiectasia affecting the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002604 ; owl:annotatedTarget "GI telangiectasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002604 ; owl:annotatedTarget "Small, enlarged blood vessels near skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_137982 ; owl:annotatedTarget "tertiary amine(1+)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22315 ; owl:annotatedTarget "Alkaloid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002605 ; owl:annotatedTarget "The presence of cell death (necrosis) affecting the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002607 ; owl:annotatedTarget "Involuntary fecal soiling in adults and children who have usually already been toilet trained." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002607 ; owl:annotatedTarget "Faecal incontinence" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002607 ; owl:annotatedTarget "Loss of bowel control" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22315 ; owl:annotatedTarget "alkaloids" . [] oboInOwl:hasDbXref , "PMID:23681421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002608 ; owl:annotatedTarget "Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002608 ; owl:annotatedTarget "Celiac disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002608 ; owl:annotatedTarget "Coeliac disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002608 ; owl:annotatedTarget "Coeliac sprue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22315 ; owl:annotatedTarget "Alkaloide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002612 ; owl:annotatedTarget "The presence of fibrosis of that part of the liver with congenital onset." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002612 ; owl:annotatedTarget "Excessive buildup of connective tissue and scarring of liver at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002613 ; owl:annotatedTarget "Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002614 ; owl:annotatedTarget "A type of hepatic necrosis that is concentrated around the necrosis of hepatocytes localized around the intrahepatic branch of portal vein." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22315 ; owl:annotatedTarget "alcaloide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22315 ; owl:annotatedTarget "alcaloides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002615 ; owl:annotatedTarget "Low Blood Pressure, vascular hypotension." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002615 ; owl:annotatedTarget "Low blood pressure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002616 ; owl:annotatedTarget "Bulge in wall of root of large artery that carries blood away from heart" . [] oboInOwl:hasDbXref , "PMID:30225143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Aneurysmal dilatation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Wider than typical opening or gap" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Aneurysm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Aneurysms" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002617 ; owl:annotatedTarget "Aneurysmal disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002619 ; owl:annotatedTarget "Enlarged and tortuous veins." . [] oboInOwl:hasDbXref , "PMID:31420554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002621 ; owl:annotatedTarget "A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002621 ; owl:annotatedTarget "Plaque build-up in arteries" . [] oboInOwl:hasDbXref , "http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972?utm_source=google&utm_medium=abstract&utm_content=atherosclerosis&utm_campaign=knowledge-panel" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002621 ; owl:annotatedTarget "Atherosclerotic cardiovascular disease" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22323 ; owl:annotatedTarget "alkyl group" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002621 ; owl:annotatedTarget "Narrowing and hardening of arteries" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22323 ; owl:annotatedTarget "alkyl groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002623 ; owl:annotatedTarget "An overriding aorta is a congenital heart defect where the aorta is positioned directly over a ventricular septal defect, instead of over the left ventricle. The result is that the aorta receives some blood from the right ventricle, which reduces the amount of oxygen in the blood. It is one of the four conditions of the Tetralogy of Fallot. The aortic root can be displaced toward the front (anteriorly) or directly above the septal defect, but it is always abnormally located to the right of the root of the pulmonary artery. The degree of override is quite variable, with 5-95% of the valve being connected to the right ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002624 ; owl:annotatedTarget "An anomaly of vein." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002624 ; owl:annotatedTarget "Abnormal vein" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22323 ; owl:annotatedTarget "groupe alkyle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002625 ; owl:annotatedTarget "Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002625 ; owl:annotatedTarget "Blood clot in a deep vein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002626 ; owl:annotatedTarget "Elongated and tortuous mesenteric veins, which comprise the inferior mesenteric vein and the superior mesenteric vein." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002626 ; owl:annotatedTarget "Venous varicosities of coeliac and mesenteric vessels" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002627 ; owl:annotatedTarget "The aortic arch crosses the right mainstem bronchus and not the left mainstem bronchus, but does not result in the creation of a vascular ring. The first branch is the left brachiocephalic artery which divides into the left carotid artery and left subclavian artery, the second branch is the right carotid artery, the third branch is the right subclavian artery." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002629 ; owl:annotatedTarget "GI arteriovenous malformation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002630 ; owl:annotatedTarget "Abnormality of the absorption of fat from the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002632 ; owl:annotatedTarget "Low-to-normal BP" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002632 ; owl:annotatedTarget "Low-to-normal blood pressure" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22323 ; owl:annotatedTarget "grupo alquilo" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_137982 ; owl:annotatedTarget "tertiary ammonium ions" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22323 ; owl:annotatedTarget "grupos alquilo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002633 ; owl:annotatedTarget "Inflammation of blood vessel." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002633 ; owl:annotatedTarget "Angiitis" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002633 ; owl:annotatedTarget "Inflammation of blood vessel" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22478 ; owl:annotatedTarget "amino alcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002634 ; owl:annotatedTarget "Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002634 ; owl:annotatedTarget "Hardened artery wall" . [] oboInOwl:hasDbXref "PMID:7648691" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002635 ; owl:annotatedTarget "In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22478 ; owl:annotatedTarget "aminoalcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002636 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in an artery that originates from the abdominal aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002637 ; owl:annotatedTarget "Brain ischemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002637 ; owl:annotatedTarget "Cerebrovascular ischemia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002637 ; owl:annotatedTarget "Disruption of blood oxygen supply to brain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002638 ; owl:annotatedTarget "Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein)." . [] oboInOwl:hasDbXref , "PMID:16265183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002639 ; owl:annotatedTarget "Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava (IVC) with the right atrium, 1 and occurs in 1/100,000 of the general population worldwide. The most common presentation is with ascites, but can range from fulminant hepatic failure (FHF) to asymptomatic forms. Obstruction of hepatic venous outflow is mainly caused by primary intravascular thrombosis, which can occur suddenly or be repeated over time, accompanied by some revascularization, accounting for the variable parenchymal hepatic damage and histologic presentation. Budd-Chiari syndrome is thus a disease, but since it occurs as a manifestation of several other diseases, this term is kept for the present for convenience." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22478 ; owl:annotatedTarget "aminoalcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002640 ; owl:annotatedTarget "A type of hypertension associated with pheochromocytoma." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002641 ; owl:annotatedTarget "Peripheral blood clot" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002642 ; owl:annotatedTarget "Arteriovenous fistulas of coeliac and mesenteric vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002643 ; owl:annotatedTarget "Respiratory difficulty as newborn." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002643 ; owl:annotatedTarget "Infantile respiratory distress" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002643 ; owl:annotatedTarget "Neonatal respiratory distress" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002643 ; owl:annotatedTarget "Newborn respiratory distress" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002643 ; owl:annotatedTarget "Respiratory distress, neonatal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22480 ; owl:annotatedTarget "amino-disaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002644 ; owl:annotatedTarget "An abnormality of the bony pelvic girdle, which is a ring of bones connecting the vertebral column to the femurs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002644 ; owl:annotatedTarget "Abnormal shape of pelvic girdle bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002645 ; owl:annotatedTarget "The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002645 ; owl:annotatedTarget "Extra bones within cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002645 ; owl:annotatedTarget "Intra sutural bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22483 ; owl:annotatedTarget "amino oligosaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002645 ; owl:annotatedTarget "Intrasutural bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002645 ; owl:annotatedTarget "Islands of bone within cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002647 ; owl:annotatedTarget "Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002647 ; owl:annotatedTarget "Tear in inner wall of large artery that carries blood away from heart" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22484 ; owl:annotatedTarget "galactosamine oligosaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002650 ; owl:annotatedTarget "The presence of an abnormal lateral curvature of the spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002652 ; owl:annotatedTarget "A general term describing features characterized by abnormal development of bones and connective tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002652 ; owl:annotatedTarget "Abnormal skeletal development" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002653 ; owl:annotatedTarget "Bone pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22494 ; owl:annotatedTarget "aminobenzoates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002655 ; owl:annotatedTarget "A disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002656 ; owl:annotatedTarget "Abnormal development of end part of bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002656 ; owl:annotatedTarget "Abnormal development of the ends of long bones in arms and legs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Abnormal susceptibility to fractures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138103 ; owl:annotatedTarget "inorganic acids" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22495 ; owl:annotatedTarget "aminobenzoic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Bone fragility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Frequent broken bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Increased bone fragility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Increased susceptibility to fractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002659 ; owl:annotatedTarget "Increased tendency to fractures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002661 ; owl:annotatedTarget "An increased tendency to fractures following trauma, with fractures occurring without pain." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002661 ; owl:annotatedTarget "Painless fractures due to injury" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22495 ; owl:annotatedTarget "Aminobenzoesaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002663 ; owl:annotatedTarget "Delayed maturation of end part of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002664 ; owl:annotatedTarget "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22506 ; owl:annotatedTarget "aminoglycans" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002664 ; owl:annotatedTarget "Abnormal tissue mass" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002664 ; owl:annotatedTarget "Cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002664 ; owl:annotatedTarget "Oncology" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002665 ; owl:annotatedTarget "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002665 ; owl:annotatedTarget "Cancer of lymphatic system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002666 ; owl:annotatedTarget "Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002666 ; owl:annotatedTarget "Chromaffin tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002666 ; owl:annotatedTarget "Chromaffin tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002667 ; owl:annotatedTarget "The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002667 ; owl:annotatedTarget "Wilms tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22527 ; owl:annotatedTarget "aminopurines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002668 ; owl:annotatedTarget "A carotid body tumor (also called paraganglionoma or chemodectoma) is a tumor found in the upper neck at the branching of the carotid artery. They arise from the chemoreceptor organ (paraganglion) located in the adventitia of the carotid artery bifurcation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002668 ; owl:annotatedTarget "Carotid body tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002668 ; owl:annotatedTarget "Paragangliomas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002669 ; owl:annotatedTarget "A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002669 ; owl:annotatedTarget "Bone cell cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002671 ; owl:annotatedTarget "The presence of a basal cell carcinoma of the skin." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002672 ; owl:annotatedTarget "GI carcinoma" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22558 ; owl:annotatedTarget "anhydro sugar" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002673 ; owl:annotatedTarget "Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002673 ; owl:annotatedTarget "Coxa valga deformity" . [] oboInOwl:hasDbXref "PMID:19125436", "PMID:29089832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002676 ; owl:annotatedTarget "Trilobar skull configuration when viewed from the front or behind." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002676 ; owl:annotatedTarget "Cloverleaf cranium shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22558 ; owl:annotatedTarget "anhydro sugars" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002676 ; owl:annotatedTarget "Cloverleaf skull shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002676 ; owl:annotatedTarget "Trilobar cranium shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002676 ; owl:annotatedTarget "Trilobar skull shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22558 ; owl:annotatedTarget "anhydrosugars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002677 ; owl:annotatedTarget "An abnormal narrowing of the foramen magnum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002677 ; owl:annotatedTarget "Little foramen magnum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002677 ; owl:annotatedTarget "Narrow foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002677 ; owl:annotatedTarget "Hypoplasia of foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002677 ; owl:annotatedTarget "Stenosis of foramen magnum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22558 ; owl:annotatedTarget "sugar anhydride" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Abnormality of skull shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Unequal skull shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Uneven skull shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Asymmetry of skull" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Skull asymmetry" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002678 ; owl:annotatedTarget "Malformation of skull shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22558 ; owl:annotatedTarget "sugar anhydrides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Abnormality of the sella turcica, a saddle-shaped depression in the sphenoid bone at the base of the human skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Anomaly of the sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Abnormality of the hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Abnormality of the pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Anomaly of the hypophysial fossa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "Anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002679 ; owl:annotatedTarget "Anomaly of the pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "A deformity of the sella turcica whereby the sella extends further anterior than normal such that the anterior clinoid process appears to overhang it, giving the appearance of the letter J on imaging of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Hour glass shaped hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Hour glass shaped pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Hour glass shaped sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "J-shaped sella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Omega shaped sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "J-shaped hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "J-shaped pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Omega shaped hypophysial fossa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138103 ; owl:annotatedTarget "mineral acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002680 ; owl:annotatedTarget "Omega shaped pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Abnormal shape of hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Abnormal shape of pituitary fossa" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Abnormal shape of sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Deformity of hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Deformity of pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Malformation of hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Malformation of pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002681 ; owl:annotatedTarget "Malformation of sella turcica" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "Anionen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Increased width of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Broad cranium" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Broad skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Increased width of cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Increased width of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Wide cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002682 ; owl:annotatedTarget "Wide skull" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "aniones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of calvarium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22563 ; owl:annotatedTarget "anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of cranial vault" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of the skull cap" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002683 ; owl:annotatedTarget "Abnormality of the skullcap" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22586 ; owl:annotatedTarget "antioxidants" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "The presence of an abnormally thick calvaria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Increased thickness of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Increased thickness of calvaria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Increased thickness of calvarium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Increased thickness of cranial vault" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Increased thickness of skull cap" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002684 ; owl:annotatedTarget "Thickened skull cap" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002686 ; owl:annotatedTarget "Maternal health problem" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22586 ; owl:annotatedTarget "antioxydant" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002687 ; owl:annotatedTarget "An abnormality of the frontal sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The frontal sinus is located within the frontal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002687 ; owl:annotatedTarget "Abnormality of sinus frontalis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002687 ; owl:annotatedTarget "Abnormality of the forehead sinus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22586 ; owl:annotatedTarget "antoxidant" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002688 ; owl:annotatedTarget "Aplasia of frontal sinus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22587 ; owl:annotatedTarget "anti-viral agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002688 ; owl:annotatedTarget "Missing frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002688 ; owl:annotatedTarget "Aplasia of frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002688 ; owl:annotatedTarget "Aplasia sinus frontalis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22587 ; owl:annotatedTarget "anti-viral agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002689 ; owl:annotatedTarget "Aplasia of the paranasal sinuses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002689 ; owl:annotatedTarget "Missing sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002689 ; owl:annotatedTarget "Absence of paranasal sinuses" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002689 ; owl:annotatedTarget "Missing paranasal sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002689 ; owl:annotatedTarget "Aplasia of paranasal sinuses" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138103 ; owl:annotatedTarget "mineral acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22587 ; owl:annotatedTarget "antiviral" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "An abnormal enlargement of the sella turcica." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Big sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Hyperplasia of sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Hyperplasia of hypophysial fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Hyperplasia of pituitary fossa" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Large hypophysial fossa" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002690 ; owl:annotatedTarget "Large pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002691 ; owl:annotatedTarget "A developmental malformation of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward such that there is an abnormal flattening of the skull base." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22587 ; owl:annotatedTarget "antiviral agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002691 ; owl:annotatedTarget "Flattening of the skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002691 ; owl:annotatedTarget "Increased basal angle of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002691 ; owl:annotatedTarget "Obtuse basal angle of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0002691 ; owl:annotatedTarget "Platybasia is malformation of the base of the skull due to softening of skull bones or a developmental anomaly, with bulging upwards of the floor of the posterior cranial fossa, upward displacement of the upper cervical vertebrae, and bony impingement on the brainstem. It results in abnormal obtuseness of the basal angle that can be demonstrated radiographically. If platybasia is associated with basilar invagination, compression of the brainstem and upper cervical cord can result. Basal Angle formed by: line joining the nasion with the centre of the pituitary fossa line joining the anterior border of the foramen magnum with the centre of the pituitary fossa normal: 125 degrees-143 degrees platybasia: > 143 degrees basilar kyphosis: < 125 degrees." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22587 ; owl:annotatedTarget "antivirals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Hypoplasia of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Small facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Small facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Underdevelopment of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Underdevelopment of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Decreased size of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Decreased size of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Flattening of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Flattening of facial skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Hypotrophic facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002692 ; owl:annotatedTarget "Hypotrophic facial skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002693 ; owl:annotatedTarget "An abnormality of the base of the skull, which forms the floor of the cranial cavity and separates the brain from other facial structures. The skull base is made up of five bones: the ethmoid, sphenoid, occipital, paired frontal, and paired parietal bones, and is subdivided into 3 regions: the anterior, middle, and posterior cranial fossae. The petro-occipital fissure subdivides the middle cranial fossa into 1 central component and 2 lateral components." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002693 ; owl:annotatedTarget "Abnormality of cranial base" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002693 ; owl:annotatedTarget "Abnormality of the skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "Increased bone density of the skull base without significant changes in bony contour." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "Dense bone of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "Hyperossification of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "Hyperostosis of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "Sclerosis of cranial base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "HyperCalcification of skull base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002694 ; owl:annotatedTarget "HyperMineralization of skull base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002696 ; owl:annotatedTarget "Any abnormality of the parietal bone of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002696 ; owl:annotatedTarget "Abnormality of the parietal bone of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002697 ; owl:annotatedTarget "The presence of symmetrical and circular openings (foramina) in the parietal bone ranging in size from a few millimeters to several centimeters wide." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002697 ; owl:annotatedTarget "Persistent foramina of the parietal bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002697 ; owl:annotatedTarget "Holes in parietal bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002697 ; owl:annotatedTarget "Openings in parietal bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Beilstein:1723525" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002699 ; owl:annotatedTarget "Any abnormality of the foramen magnum." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "CAS:3130-87-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "An abnormal increase in the size of the foramen magnum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "Big foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "Dilation of foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "Wide foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "Increased circumference of foramen magnum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002700 ; owl:annotatedTarget "Increased diameter of foramen magnum" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138131 ; owl:annotatedTarget "a Delta(5),Delta(7)-sterol" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Gmelin:279043" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "An abnormality of the process of ossification of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of skull bone formation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of ossification of calvarium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of ossification of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone calcification of calvarium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone calcification of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone calcification of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone formation of calvarium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone formation of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone mineralization of calvarium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone mineralization of cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002703 ; owl:annotatedTarget "Abnormality of bone mineralization of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "The presence of a high and narrow palate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "Gothic palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "High vaulted palate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "High, narrow palate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "Narrow, high-arched roof of mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002705 ; owl:annotatedTarget "Narrow, highly arched roof of mouth" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Reaxys:1723525" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "Palatal angioectasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "Palatal telangiectasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "Telangiectasia of the roof of the mouth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "asparagine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "Palatal spider veins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002707 ; owl:annotatedTarget "Spider veins of the roof of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002708 ; owl:annotatedTarget "Unusual prominence of the median palatal raphe, which is the ridge formed by the fusion of the two plates of the skull that form the hard palate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002708 ; owl:annotatedTarget "Prominent central palatal ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002708 ; owl:annotatedTarget "Prominent central ridge on roof of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002708 ; owl:annotatedTarget "Prominent medial palatal suture" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002710 ; owl:annotatedTarget "A depression located at an oral commissure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002710 ; owl:annotatedTarget "Commissural labial pits" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002710 ; owl:annotatedTarget "Lip pits at corners of the mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002710 ; owl:annotatedTarget "Pits at the corners of the lips" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "2,4-diamino-4-oxobutanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Increased depth of the median tongue furrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep central lingual furrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep central lingual groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep central tongue furrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep central tongue groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep median lingual furrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep median lingual groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep median tongue furrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Deep median tongue groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002711 ; owl:annotatedTarget "Exaggerated median lingual furrow" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "2-amino-3-carbamoylpropanoic acid" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002714 ; owl:annotatedTarget "A morphological abnormality of the mouth in which the angle of the mouth is downturned. The oral commissures are positioned inferior to the midline labial fissure." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002714 ; owl:annotatedTarget "Downturned corners of mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002714 ; owl:annotatedTarget "Downturned corners of the mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002714 ; owl:annotatedTarget "Downturned mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002714 ; owl:annotatedTarget "Downturned oral commisures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "ASN" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002715 ; owl:annotatedTarget "An abnormality of the immune system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002715 ; owl:annotatedTarget "Abnormality of the immune system" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002715 ; owl:annotatedTarget "Immunological abnormality" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Asn" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002716 ; owl:annotatedTarget "Enlargment (swelling) of a lymph node." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002716 ; owl:annotatedTarget "Swollen lymph nodes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Asparagin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Bacterial infections, recurrent" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_138141 ; owl:annotatedTarget "MetaCyc:17a-hydroxy-C21-steroids" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "DL-Asparagine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Frequent bacterial infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Increased susceptibility to bacterial infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Recurrent bacterial infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Recurrent major bacterial infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002718 ; owl:annotatedTarget "Prone to bacterial infection" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Increased susceptibility to infections." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Frequent infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Frequent, severe infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Increased frequency of infection" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Predisposition to infections" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "Hasp" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Recurrent infections" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "Susceptibility to infection" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002719 ; owl:annotatedTarget "infections, recurrent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "N" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002720 ; owl:annotatedTarget "Decreased levels of immunoglobulin A (IgA)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22653 ; owl:annotatedTarget "asparagina" . [] oboInOwl:hasDbXref "PMID:20042227" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002721 ; owl:annotatedTarget "Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002721 ; owl:annotatedTarget "Decreased immune function" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002722 ; owl:annotatedTarget "An increased susceptibility to abscess formation, as manifested by a medical history of recurrent abscesses." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "PMID:4386082" . [] oboInOwl:hasDbXref "GO:0045728" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002723 ; owl:annotatedTarget "An absence of the phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002724 ; owl:annotatedTarget "An increased susceptibility to Aspergillus infections, as manifested by a history of recurrent episodes of Aspergillus infections." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002724 ; owl:annotatedTarget "Aspergillus infections, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002725 ; owl:annotatedTarget "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002725 ; owl:annotatedTarget "SLE" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002726 ; owl:annotatedTarget "Increased susceptibility to Staphylococcus aureus infections, as manifested by recurrent episodes of Staphylococcus aureus infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002726 ; owl:annotatedTarget "Staphylococcus aureus infections, recurrent" . [] oboInOwl:hasDbXref , "PMID:20859203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002728 ; owl:annotatedTarget "Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "PMID:4394351" . [] oboInOwl:hasDbXref , "PMID:23281438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002729 ; owl:annotatedTarget "Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002730 ; owl:annotatedTarget "A chronic form of lymphadenopathy that is not related to infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002731 ; owl:annotatedTarget "A reduction in the rate of apoptosis in lymphocytes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "PMID:4721772" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002732 ; owl:annotatedTarget "Underdevelopment of the lymph nodes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002732 ; owl:annotatedTarget "Small lymph nodes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "PMID:5016260" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002733 ; owl:annotatedTarget "A structural lymph node abnormality." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002733 ; owl:annotatedTarget "Abnormal lymph node histology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002733 ; owl:annotatedTarget "Abnormality of the lymph nodes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "PMID:5074276" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002737 ; owl:annotatedTarget "Increased thickness of bone of skull base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002737 ; owl:annotatedTarget "Increased thickness of skull base" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002737 ; owl:annotatedTarget "Thick skull base" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "aspartate family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002738 ; owl:annotatedTarget "Underdevelopment of frontal sinus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002738 ; owl:annotatedTarget "Decreased volume of frontal sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002738 ; owl:annotatedTarget "Small frontal sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0002738 ; owl:annotatedTarget "Decreased pneumatization of frontal sinus" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138141 ; owl:annotatedTarget "a 17alpha-hydroxy-C21-steroid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "aspartic acid family amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002738 ; owl:annotatedTarget "Hypotrophic frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002740 ; owl:annotatedTarget "Increased susceptibility to infections with Escherichia coli, as manifested by recurrent episodes of infection with this agent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002740 ; owl:annotatedTarget "E coli infections, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002741 ; owl:annotatedTarget "Increased susceptibility to Serratia marcescens infections, as manifested by recurrent episodes of Serratia marcescens infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002742 ; owl:annotatedTarget "Increased susceptibility to Klebsiella infections, as manifested by recurrent episodes of Klebsiella infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002742 ; owl:annotatedTarget "Klebsiella infections, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002743 ; owl:annotatedTarget "Increased susceptibility to enteroviral infections, as manifested by recurrent episodes of enteroviral infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002744 ; owl:annotatedTarget "Cleft lip and cleft palate affecting both sides of the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002744 ; owl:annotatedTarget "Right and left cleft lip and palate" . [] oboInOwl:hasDbXref , "PMID:17944749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "A thickened white patch on the oral mucosa that cannot be rubbed off." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "aspartic acid family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral idiopathic keratosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral idiopathic leukoplakia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral idiopathic white patch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral leucoplakia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral leukokeratosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral leukoplasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral white patch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "Oral white plaque" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002745 ; owl:annotatedTarget "leukokeratosis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002747 ; owl:annotatedTarget "Decreased lung function due to weak breathing muscles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "oxaloacetate family amino acid" . [] oboInOwl:hasDbXref "GARD:0005700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002748 ; owl:annotatedTarget "Rickets is divided into two major categories including calcipenic and phosphopenic. Hypophosphatemia is described as a common manifestation of both categories. Hypophosphatemic rickets is the most common type of rickets that is characterized by low levels of serum phosphate, resistance to ultraviolet radiation or vitamin D intake. There are several issues involved in hypophosphatemic rickets such as calcium, vitamin D, phosphorus deficiencies. Moreover, other disorder can be associated with its occurrence such as absorption defects due to pancreatic, intestinal, gastric, and renal disorders and hepatobiliary disease. Symptoms are usually seen in childhood and can be varied in severity. Severe forms may be linked to bowing of the legs, poor bone growth, and short stature as well as joint and bone pain. Hypophosphatemic rickets are associated with renal excretion of phosphate, hypophosphatemia, and mineral defects in bones. The familial type of the disease is the most common type of rickets." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002748 ; owl:annotatedTarget "Weak and soft bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "oxaloacetate family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002749 ; owl:annotatedTarget "Osteomalacia is a general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002749 ; owl:annotatedTarget "Softening of the bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "oxaloacetate/aspartate family amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002750 ; owl:annotatedTarget "A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002750 ; owl:annotatedTarget "Delayed bone maturation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002750 ; owl:annotatedTarget "Delayed skeletal development" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22658 ; owl:annotatedTarget "oxaloacetate/aspartate family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002751 ; owl:annotatedTarget "An abnormal curvature of the spine in both a coronal (lateral) and sagittal (back-to-front) plane." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002753 ; owl:annotatedTarget "Abnormal thinning of the cortical region of bones." . [] oboInOwl:hasDbXref , "PMID:15276398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002754 ; owl:annotatedTarget "Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002754 ; owl:annotatedTarget "Bone infection" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002756 ; owl:annotatedTarget "A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002756 ; owl:annotatedTarget "Spontaneous fracture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002756 ; owl:annotatedTarget "Pathologic fractures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002756 ; owl:annotatedTarget "Spontaneous fractures" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "Beilstein:774618" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Increased fracture rate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Increased fractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Multiple fractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Multiple spontaneous fractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Recurrent fractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002757 ; owl:annotatedTarget "Varying degree of multiple fractures" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "CAS:617-45-8" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002758 ; owl:annotatedTarget "Degenerative joint disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002761 ; owl:annotatedTarget "Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002761 ; owl:annotatedTarget "Generalised joint laxity" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002761 ; owl:annotatedTarget "Hypermobility of all joints" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002761 ; owl:annotatedTarget "Joint laxity, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002761 ; owl:annotatedTarget "Joint laxity, generalized" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002762 ; owl:annotatedTarget "Presence of more than one exostosis. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "CAS:617-45-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002763 ; owl:annotatedTarget "Any morphological abnormality of cartilage." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002763 ; owl:annotatedTarget "Abnormal shape of cartilage" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "CAS:617-45-8" . [] oboInOwl:hasDbXref , "PMID:29246349" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002764 ; owl:annotatedTarget "Punctate (speckled, dot-like) deposition of calcium of calcium salts in the articular cartilage (cartilage located in joints)." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "Gmelin:185140" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002766 ; owl:annotatedTarget "Relatively short spine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002777 ; owl:annotatedTarget "Narrowing of windpipe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002778 ; owl:annotatedTarget "A structural anomaly of the trachea." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "Reaxys:774618" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002779 ; owl:annotatedTarget "Floppy windpipe" . [] oboInOwl:hasDbXref "PMID:15764786" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002780 ; owl:annotatedTarget "Weakness or softness of the cartilage in the walls of the bronchial tubes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002781 ; owl:annotatedTarget "Increased resistance to the passage of air in the upper airway." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "Aspartic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002781 ; owl:annotatedTarget "Upper airway obstruction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002783 ; owl:annotatedTarget "An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002783 ; owl:annotatedTarget "Recurrent chest infections" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002786 ; owl:annotatedTarget "Weakness of the cartilage in the trachea and the bronchi, resulting in a floppy (non-rigid) airway. Affected persons may have difficulties to maintain patency of the airways." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "aspartic acid" . [] oboInOwl:hasDbXref , "PMID:18663210" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002787 ; owl:annotatedTarget "Calcification (abnormal deposits of calcium) in the tracheal tissues." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002787 ; owl:annotatedTarget "Tracheal calcifications" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002788 ; owl:annotatedTarget "An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002788 ; owl:annotatedTarget "Recurrent URI" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002788 ; owl:annotatedTarget "Recurrent colds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002788 ; owl:annotatedTarget "Upper respiratory tract infections, recurrent" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "(+-)-Aspartic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002789 ; owl:annotatedTarget "Very rapid breathing." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002789 ; owl:annotatedTarget "Increased respiratory rate or depth of breathing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002790 ; owl:annotatedTarget "Impaired breathing in newborn" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_13850 ; owl:annotatedTarget "apoprotein" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "(R,S)-Aspartic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002791 ; owl:annotatedTarget "A reduction in the amount of air transported into the pulmonary alveoli by breathing, leading to hypercapnia (increase in the partial pressure of carbon dioxide)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002791 ; owl:annotatedTarget "Slow breathing" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "2-aminobutanedioic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002791 ; owl:annotatedTarget "Under breathing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002792 ; owl:annotatedTarget "An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002793 ; owl:annotatedTarget "An anomaly of the rhythm or depth of breathing." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002793 ; owl:annotatedTarget "Abnormal pattern of respiration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002793 ; owl:annotatedTarget "Abnormal respiratory patterns" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002793 ; owl:annotatedTarget "Unusual breathing patterns" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "Asp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002795 ; owl:annotatedTarget "Abnormal respiration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002795 ; owl:annotatedTarget "Functional respiratory abnormality" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002795 ; owl:annotatedTarget "Respiratory problem" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "D" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002797 ; owl:annotatedTarget "Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002797 ; owl:annotatedTarget "Breakdown of bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002797 ; owl:annotatedTarget "Increased bone resorption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002803 ; owl:annotatedTarget "One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002803 ; owl:annotatedTarget "congenital contractures" . [] oboInOwl:hasDbXref , "PMID:23050160" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002804 ; owl:annotatedTarget "Multiple congenital contractures in different body areas." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002805 ; owl:annotatedTarget "Accelerated bone age after puberty" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "DL-Aminosuccinic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002808 ; owl:annotatedTarget "Exaggerated anterior convexity of the thoracic vertebral column." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22660 ; owl:annotatedTarget "DL-Asparagic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002808 ; owl:annotatedTarget "Hunched back" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002808 ; owl:annotatedTarget "Round back" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002810 ; owl:annotatedTarget "Dumbbell shaped metaphysis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22676 ; owl:annotatedTarget "auxins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002810 ; owl:annotatedTarget "Dumbbell shaped wide portion of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "Base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002812 ; owl:annotatedTarget "Coxa vara includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002813 ; owl:annotatedTarget "Any abnormality of bones of the arms or legs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002813 ; owl:annotatedTarget "Abnormal shape of limb bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "base" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002813 ; owl:annotatedTarget "Arm and/or leg bone differences" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002813 ; owl:annotatedTarget "Limb abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002814 ; owl:annotatedTarget "An abnormality of the leg." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "base" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002814 ; owl:annotatedTarget "Abnormality of the lower limb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002814 ; owl:annotatedTarget "Lower limb deformities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002815 ; owl:annotatedTarget "An abnormality of the knee joint or surrounding structures." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13850 ; owl:annotatedTarget "apoproteins" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "Base1" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002815 ; owl:annotatedTarget "Abnormality of the knee" . [] oboInOwl:hasDbXref , "PMID:9580896" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002816 ; owl:annotatedTarget "An abnormally increased extension of the knee joint, so that the knee can bend backwards." . [] a owl:Axiom ; rdfs:label "Genu recurvatum" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002816 ; owl:annotatedTarget "MEDDRA:10018194" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/genu_recurvatum" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002816 ; owl:annotatedTarget "Back knee" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/genu_recurvatum" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002816 ; owl:annotatedTarget "Knee hyperextension" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "Base2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002817 ; owl:annotatedTarget "An abnormality of the arm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002817 ; owl:annotatedTarget "Abnormality of the upper limb" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "Basen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002818 ; owl:annotatedTarget "An abnormality of the radius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002821 ; owl:annotatedTarget "Charcot arthropathy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002821 ; owl:annotatedTarget "Charcot joint" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "Nucleobase" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002823 ; owl:annotatedTarget "Any anomaly of the structure of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002823 ; owl:annotatedTarget "Abnormality of the thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22695 ; owl:annotatedTarget "bases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002825 ; owl:annotatedTarget "The presence of a tail-like skin appendage located adjacent to the sacrum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002825 ; owl:annotatedTarget "Human tail" . [] oboInOwl:hasDbXref , "PMID:19232556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002826 ; owl:annotatedTarget "An anomalous radiographic appearance of the developing pelvis, in which the greater ischiadic noth (incisura ischiadica major) is shallow and the pelvis takes on the appearance said to resemble a halberd (a weapon especially of the 15th and 16th centuries consisting typically of a battle-ax and pike mounted on a handle)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22718 ; owl:annotatedTarget "benzoate anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002827 ; owl:annotatedTarget "Displacement of the femur from its normal location in the hip joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002827 ; owl:annotatedTarget "Dislocated hips" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002827 ; owl:annotatedTarget "Dislocation of hip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002827 ; owl:annotatedTarget "Hip dislocation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002829 ; owl:annotatedTarget "Joint pain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002829 ; owl:annotatedTarget "Joint pain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002829 ; owl:annotatedTarget "Joint pains" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22727 ; owl:annotatedTarget "benzopyrans" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002831 ; owl:annotatedTarget "Long tailbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22728 ; owl:annotatedTarget "benzopyrroles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002832 ; owl:annotatedTarget "An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs)." . [] oboInOwl:hasDbXref , "PMID:11930062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002833 ; owl:annotatedTarget "Disseminated multifocal hemangiomatous or lymphangiomatous lesions of the skeleton. The lesions are lytic, well-defined, round or oval lesions within the medullary cavity, and they have an intact cortex, and manifest variable peripheral sclerosis and may exhibit endosteal scalloping." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002834 ; owl:annotatedTarget "Flared metaphysis of thigh bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002835 ; owl:annotatedTarget "Inspiration of a foreign object into the airway." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002835 ; owl:annotatedTarget "Pulmonary aspiration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22744 ; owl:annotatedTarget "benzyl" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002836 ; owl:annotatedTarget "Eversion of the posterior bladder wall through the congenitally absent lower anterior abdominal wall and anterior bladder wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002836 ; owl:annotatedTarget "Ectopia vesicae" . [] oboInOwl:hasDbXref , "ISBN:0199747725", "PMID:28261574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002837 ; owl:annotatedTarget "An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002837 ; owl:annotatedTarget "Bronchitis, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002839 ; owl:annotatedTarget "Abnormal function of a sphincter of the urinary bladder." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138675 ; owl:annotatedTarget "gas molecular entities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22744 ; owl:annotatedTarget "Bn" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002840 ; owl:annotatedTarget "Inflammation of a lymph node." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002840 ; owl:annotatedTarget "Inflammation of the lymph nodes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002841 ; owl:annotatedTarget "Increased susceptibility to fungal infections, as manifested by multiple episodes of fungal infection." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22744 ; owl:annotatedTarget "C6H5-CH2-" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002841 ; owl:annotatedTarget "Recurrent fungal infections" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002842 ; owl:annotatedTarget "Increased susceptibility to infections with Burkholderia cepacia, as manifested by recurrent episodes of infection with this agent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002843 ; owl:annotatedTarget "An abnormality of T cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22744 ; owl:annotatedTarget "phenylalanine side-chain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002843 ; owl:annotatedTarget "Abnormal T cells" . [] oboInOwl:hasDbXref , "PMID:18725575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002846 ; owl:annotatedTarget "A structural abnormality of B cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002846 ; owl:annotatedTarget "Abnormal B cells" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22744 ; owl:annotatedTarget "phenylmethyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002847 ; owl:annotatedTarget "Impaired production of memory cells, the B cells that persist for years or an entire lifetime and which confer rapid and enhanced response to secondary challenge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002848 ; owl:annotatedTarget "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against bacterial polysaccharides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002849 ; owl:annotatedTarget "Absence of germinal centers in lymph nodes. Germinal centers are the parts of lymph nodes in which B lymphocytes proliferate, differentiate, mutate through somatic hypermutation and class switch during antibody responses." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22860 ; owl:annotatedTarget "amino acid betaines" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002849 ; owl:annotatedTarget "Absence of lymph node germinal centre" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002849 ; owl:annotatedTarget "Lymph nodes lack germinal centre" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002849 ; owl:annotatedTarget "Lymphoid germinal centre defect" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22860 ; owl:annotatedTarget "amino-acid betaines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002850 ; owl:annotatedTarget "An abnormally decreased level of immunoglobulin M (IgM) in blood." . [] oboInOwl:hasDbXref "PMID:11531958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002853 ; owl:annotatedTarget "An elevated proportion of T cells that express human leukocyte antigen (HLA)-DR. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002857 ; owl:annotatedTarget "The legs angle inward, such that the knees are close together and the ankles far apart." . [] a owl:Axiom ; rdfs:label "Knock-knee" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002857 ; owl:annotatedTarget "MEDDRA:10023480" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002857 ; owl:annotatedTarget "Knock knees" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002858 ; owl:annotatedTarget "The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22860 ; owl:annotatedTarget "betaines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002858 ; owl:annotatedTarget "Noncancerous growth of membranes covering brain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002860 ; owl:annotatedTarget "The presence of squamous cell carcinoma of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002860 ; owl:annotatedTarget "Squamous cell cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002861 ; owl:annotatedTarget "The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002861 ; owl:annotatedTarget "Cancer of skin pigment cells" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002861 ; owl:annotatedTarget "Skin cancer (melanoma)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002862 ; owl:annotatedTarget "The presence of a carcinoma of the urinary bladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002863 ; owl:annotatedTarget "Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002865 ; owl:annotatedTarget "The presence of a medullary carcinoma of the thyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002865 ; owl:annotatedTarget "Medullary thyroid cancer" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22868 ; owl:annotatedTarget "Bile acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002866 ; owl:annotatedTarget "Underdevelopment of the ilium ala." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22868 ; owl:annotatedTarget "bile salts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002867 ; owl:annotatedTarget "An abnormality of the ilium, the largest and uppermost bone of the pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002868 ; owl:annotatedTarget "Decreased width of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally)." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002868 ; owl:annotatedTarget "Narrow iliac wings" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138675 ; owl:annotatedTarget "gaseous molecular entities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22918 ; owl:annotatedTarget "branched chain amino acids" . [] oboInOwl:hasDbXref , "PMID:28744080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002869 ; owl:annotatedTarget "Widening of the ilium ala, that is of the wing of the ilium, combined with external rotation, leading to a flared appearance of the iliac wing." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002869 ; owl:annotatedTarget "Flared iliac wings" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002870 ; owl:annotatedTarget "A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002871 ; owl:annotatedTarget "Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002872 ; owl:annotatedTarget "Recurrent episodes of apnea that are precipitated by factors such as illness, fatigue, or stress." . [] oboInOwl:hasDbXref "PMID:29763022" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002875 ; owl:annotatedTarget "Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002875 ; owl:annotatedTarget "Exertional breathlessness" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002875 ; owl:annotatedTarget "Exertional dyspnoea" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002875 ; owl:annotatedTarget "Shortness of breathing upon physical activity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002876 ; owl:annotatedTarget "Episodes of very rapid breathing." . [] oboInOwl:hasDbXref "PMID:20308760" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002877 ; owl:annotatedTarget "An abnormal reduction in alveolar ventilation occuring during sleep. This is characterized by a rise in arterial carbon dioxide." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002877 ; owl:annotatedTarget "Nocturnal hypopnea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002877 ; owl:annotatedTarget "Nocturnal slow breathing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002877 ; owl:annotatedTarget "Nocturnal under breathing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002878 ; owl:annotatedTarget "A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002878 ; owl:annotatedTarget "Respiratory failure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002879 ; owl:annotatedTarget "Abnormally increased variability of the size of the vertebral bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002882 ; owl:annotatedTarget "Recurrent bouts of sudden, severe apnea that may be life-threatening." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "CAS:7440-70-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002883 ; owl:annotatedTarget "Hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "calcium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002883 ; owl:annotatedTarget "Rapid breathing" . [] oboInOwl:hasDbXref , "eMedicine:986802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002884 ; owl:annotatedTarget "A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002885 ; owl:annotatedTarget "A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults." . [] oboInOwl:hasDbXref , "PMID:17268589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002886 ; owl:annotatedTarget "A tumor that develops in the retrostyloid compartment of the parapharyngeal space, arising from an island of paraganglion tissue derived from the neural crest that is located on the vagus nerve." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002886 ; owl:annotatedTarget "Glomus vagale tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002886 ; owl:annotatedTarget "Vagal nerve tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002888 ; owl:annotatedTarget "The presence of an ependymoma of the central nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002890 ; owl:annotatedTarget "The presence of a carcinoma of the thyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002891 ; owl:annotatedTarget "The presence of a leiomyosarcoma of the uterus." . [] oboInOwl:hasDbXref , "PMID:32119338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002893 ; owl:annotatedTarget "A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "20Ca" . [] a owl:Axiom ; rdfs:label "Pituitary adenoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002893 ; owl:annotatedTarget "ICD-O:M8272/0" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002893 ; owl:annotatedTarget "Noncancerous tumor in pituitary gland" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002893 ; owl:annotatedTarget "Noncancerous tumour in pituitary gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the pancreas." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "Cancer of the pancreas" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "Pancreatic cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "Pancreatic tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "Pancreatic tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002894 ; owl:annotatedTarget "increased risk of pancreatic cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002895 ; owl:annotatedTarget "The presence of a papillary adenocarcinoma of the thyroid gland." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "Ca" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002896 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002896 ; owl:annotatedTarget "Liver cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002896 ; owl:annotatedTarget "Liver tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002896 ; owl:annotatedTarget "Liver tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002897 ; owl:annotatedTarget "A benign tumor of the parathyroid gland that can cause hyperparathyroidism." . [] a owl:Axiom ; rdfs:label "Benign neoplasm: Parathyroid gland" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002897 ; owl:annotatedTarget "ICD-10:D35.1" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002898 ; owl:annotatedTarget "Embryonal tumours" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "Ca" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002900 ; owl:annotatedTarget "An abnormally decreased potassium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002900 ; owl:annotatedTarget "Low blood potassium levels" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "Calcium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "Kalzium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002901 ; owl:annotatedTarget "An abnormally decreased calcium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002901 ; owl:annotatedTarget "Low blood calcium levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "calcio" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002902 ; owl:annotatedTarget "An abnormally decreased sodium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002902 ; owl:annotatedTarget "Low blood sodium levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_138675 ; owl:annotatedTarget "gaseous molecular entity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_22984 ; owl:annotatedTarget "calcium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002904 ; owl:annotatedTarget "An increased amount of bilirubin in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002904 ; owl:annotatedTarget "High blood bilirubin levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "PMID:24168430" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002905 ; owl:annotatedTarget "An abnormally increased phosphate concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002905 ; owl:annotatedTarget "High blood phosphate levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002907 ; owl:annotatedTarget "Microscopic hematuria detected by dipstick or microscopic examination of the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002907 ; owl:annotatedTarget "Small amount of blood in urine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002909 ; owl:annotatedTarget "An increased concentration of all types of amino acid in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002909 ; owl:annotatedTarget "Generalised aminoaciduria" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002909 ; owl:annotatedTarget "Generalised nonspecific aminoaciduria" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "carbamoyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "-C(O)NH2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002910 ; owl:annotatedTarget "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002910 ; owl:annotatedTarget "High liver enzymes" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "-CONH2" . [] oboInOwl:hasDbXref , "PMID:26101005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002912 ; owl:annotatedTarget "Increased concentration of methylmalonic acid in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "aminocarbonyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002913 ; owl:annotatedTarget "Presence of myoglobin in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "carbamyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002914 ; owl:annotatedTarget "An increased concentration of chloride in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002914 ; owl:annotatedTarget "Increased urinary chloride" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "carbamyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002916 ; owl:annotatedTarget "An abnormality of chromosome segregation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23004 ; owl:annotatedTarget "carboxamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002917 ; owl:annotatedTarget "An abnormally decreased magnesium concentration in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002917 ; owl:annotatedTarget "Low blood Mg levels" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_139120 ; owl:annotatedTarget "MetaCyc:Carotenoid-beta-end-group" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23014 ; owl:annotatedTarget "carbon oxides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002917 ; owl:annotatedTarget "Low blood magnesium levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23014 ; owl:annotatedTarget "oxides of carbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002918 ; owl:annotatedTarget "An abnormally increased magnesium concentration in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002918 ; owl:annotatedTarget "High blood Mg levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002918 ; owl:annotatedTarget "High blood magnesium levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23019 ; owl:annotatedTarget "carbonyl" . [] oboInOwl:hasDbXref , "PMID:11344564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002919 ; owl:annotatedTarget "High levels of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the urine. Ketone bodies are insignificant in the blood and urine of normal individuals in the postprandial or overnight-fasted state." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002919 ; owl:annotatedTarget "Ketone bodies in urine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0002919 ; owl:annotatedTarget "Ketoaciduria" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23019 ; owl:annotatedTarget "carbonyl group" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23019 ; owl:annotatedTarget "carbonyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002920 ; owl:annotatedTarget "The concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), is below the lower limit of normal in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002921 ; owl:annotatedTarget "An abnormality of the cerebrospinal fluid (CSF)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002921 ; owl:annotatedTarget "Abnormal CSF findings" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23019 ; owl:annotatedTarget ">C=O" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002921 ; owl:annotatedTarget "Abnormality of the CSF" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23042 ; owl:annotatedTarget "carotene" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming", "PMID:29114301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002922 ; owl:annotatedTarget "Increased concentration of protein in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002923 ; owl:annotatedTarget "The presence in the serum of an autoantibody directed against the Fc portion of IgG." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002925 ; owl:annotatedTarget "Increased concentration of thyroid-stimulating hormone (TSH) in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002925 ; owl:annotatedTarget "High TSH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002925 ; owl:annotatedTarget "TSH excess" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23042 ; owl:annotatedTarget "carotenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002926 ; owl:annotatedTarget "An abnormal functionality of the thyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002926 ; owl:annotatedTarget "Abnormal thyroid function" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23042 ; owl:annotatedTarget "carotenes" . [] oboInOwl:hasDbXref , "PMID:18901181", "PMID:20240447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002927 ; owl:annotatedTarget "An increased concentration of histidine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002927 ; owl:annotatedTarget "High urine histidine levels" . [] oboInOwl:hasDbXref , "PMID:24847459" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002930 ; owl:annotatedTarget "Reduced sensitivity of end organs to thyroid hormone characterized by elevated serum levels of free thyroid hormone with nonsuppressed thyroid stimulating hormone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002932 ; owl:annotatedTarget "A reduction in aldehyde oxidase level." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139120 ; owl:annotatedTarget "a carotenoid beta-end derivative" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23044 ; owl:annotatedTarget "CAS:36-88-4" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002933 ; owl:annotatedTarget "Ventral hernia refers to a condition in which abdominal contents protrude through a weakened portion of the abdominal wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002936 ; owl:annotatedTarget "An abnormal reduction in sensation in the distal portions of the extremities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002936 ; owl:annotatedTarget "Decreased sensation in extremities" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23044 ; owl:annotatedTarget "carotenoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002937 ; owl:annotatedTarget "Absence of one half of the vertebral body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002937 ; owl:annotatedTarget "Hemi-vertebrae" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002937 ; owl:annotatedTarget "Missing part of vertebrae" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23044 ; owl:annotatedTarget "carotenes and carotenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002938 ; owl:annotatedTarget "An abnormal accentuation of the inward curvature of the spine in the lumbar region." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002938 ; owl:annotatedTarget "Excessive inward curvature of lower spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002942 ; owl:annotatedTarget "Over curvature of the thoracic region, leading to a round back or if sever to a hump." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23044 ; owl:annotatedTarget "carotenoids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23045 ; owl:annotatedTarget "carotenols" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23045 ; owl:annotatedTarget "hydroxycarotenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002945 ; owl:annotatedTarget "Decreased height of the intervertebral disk." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23075 ; owl:annotatedTarget "glycotetraosylceramides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002947 ; owl:annotatedTarget "Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002947 ; owl:annotatedTarget "Rounded neck" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "chlorine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002948 ; owl:annotatedTarget "A developmental defect leading to the union of two adjacent vertebrae." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002948 ; owl:annotatedTarget "Spinal fusion" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "17Cl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002949 ; owl:annotatedTarget "Cervical spine fusion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002949 ; owl:annotatedTarget "Fused neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002951 ; owl:annotatedTarget "Congenital absence of a part of the vermis of cerebellum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002953 ; owl:annotatedTarget "Compression fracture of a vertebral body" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002953 ; owl:annotatedTarget "Vertebral compression fractures" . [] oboInOwl:hasDbXref , "PMID:10908370", "PMID:937513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002955 ; owl:annotatedTarget "A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "Chlor" . [] oboInOwl:hasDbXref "PMID:26233425" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002958 ; owl:annotatedTarget "Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002958 ; owl:annotatedTarget "Immune dysregulation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002958 ; owl:annotatedTarget "Unregulated immune response" . [] oboInOwl:hasDbXref , "PMID:11544001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002959 ; owl:annotatedTarget "An impairment of the class-switch recombination process that normally leads B lymphocytes to produce IgG, IgA, or IgE." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "Cl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002960 ; owl:annotatedTarget "The occurrence of an immune reaction against the organism's own cells or tissues." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002960 ; owl:annotatedTarget "Autoimmune disease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002960 ; owl:annotatedTarget "Autoimmune disorder" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002960 ; owl:annotatedTarget "Autoimmunity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002961 ; owl:annotatedTarget "Selective deficiency of one or more, but not all, classes of immunoglobulins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002963 ; owl:annotatedTarget "Delay in cutaneous immune reaction to specific antigens mediated not by antibodies but by cells. The delayed hypersensitivity test is an immune function test measuring the presence of activated T cells that recognize a specific antigen and is performed by injecting a small amount of the antigen into the skin. The area of the injection is examined 48-72 hours thereafter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002965 ; owl:annotatedTarget "Inability to react to a delayed hypersensitivity skin test." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002967 ; owl:annotatedTarget "Abnormal positioning in which the elbows are turned out." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002967 ; owl:annotatedTarget "Outward turned elbows" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "chlore" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002970 ; owl:annotatedTarget "A positional abnormality marked by outward bowing of the legs in which the knees stay wide apart when a person stands with the feet and ankles together." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002970 ; owl:annotatedTarget "Outward bow-leggedness" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002970 ; owl:annotatedTarget "Outward bowing at knees" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "chlorine" . [] oboInOwl:hasDbXref "PMID:15130947" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002971 ; owl:annotatedTarget "Absence of the fingerlike protrusive, actin-dependent structures found on the surface of peripheral blood lymphocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002972 ; owl:annotatedTarget "Decreased ability to react to a delayed hypersensitivity skin test." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002973 ; owl:annotatedTarget "An abnormality of the lower arm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "chlorum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002973 ; owl:annotatedTarget "Abnormality of the forearm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23116 ; owl:annotatedTarget "cloro" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002974 ; owl:annotatedTarget "An abnormal osseous union (fusion) between the radius and the ulna." . [] a owl:Axiom ; rdfs:label "Radioulnar synostosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002974 ; owl:annotatedTarget "MEDDRA:10037798" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002974 ; owl:annotatedTarget "Fused forearm bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002977 ; owl:annotatedTarget "Absence or underdevelopment of tissue in the central nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002977 ; owl:annotatedTarget "Absent/underdeveloped central nervous system tissue" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002977 ; owl:annotatedTarget "Aplasia/Hypoplasia involving the CNS" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23240 ; owl:annotatedTarget "chromophore" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002979 ; owl:annotatedTarget "A bending or abnormal curvature affecting a long bone of the leg." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002979 ; owl:annotatedTarget "Bowed legs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002979 ; owl:annotatedTarget "Bowed lower limbs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23240 ; owl:annotatedTarget "chromophores" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002980 ; owl:annotatedTarget "Bowing (abnormal curvature) of the femur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002980 ; owl:annotatedTarget "Bowed femura" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002980 ; owl:annotatedTarget "Bowed femurs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002980 ; owl:annotatedTarget "Bowed thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23354 ; owl:annotatedTarget "coenzyme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002981 ; owl:annotatedTarget "An abnormality of the calf, i.e. of the posterior part of the lower leg." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002981 ; owl:annotatedTarget "Abnormality of the calf" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "Beilstein:3903503" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23354 ; owl:annotatedTarget "coenzymes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002982 ; owl:annotatedTarget "A bending or abnormal curvature of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002982 ; owl:annotatedTarget "Bowed shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002982 ; owl:annotatedTarget "Bowed shinbone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23357 ; owl:annotatedTarget "cofactor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002983 ; owl:annotatedTarget "The presence of abnormally small extremities." . [] a owl:Axiom ; rdfs:label "Micromelia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002983 ; owl:annotatedTarget "MEDDRA:10027546" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002983 ; owl:annotatedTarget "Smaller or shorter than typical limbs" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23357 ; owl:annotatedTarget "cofactors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002984 ; owl:annotatedTarget "Underdevelopment of the radius." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002984 ; owl:annotatedTarget "Underdeveloped outer large forearm bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002986 ; owl:annotatedTarget "A bending or abnormal curvature of the radius." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002986 ; owl:annotatedTarget "Bowing of outer large bone of the forearm" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002986 ; owl:annotatedTarget "Bowing of radius bone of the forearm" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "entidad molecular" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002987 ; owl:annotatedTarget "An elbow contracture that limits the ability of the elbow joint to be extended (straightened), meaning that the elbow is fixed in an flexed (bent) position." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "entidades moleculares" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002990 ; owl:annotatedTarget "Absence of the fibula." . [] a owl:Axiom ; rdfs:label "Fibula agenesis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0002990 ; owl:annotatedTarget "MEDDRA:10054882" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002990 ; owl:annotatedTarget "Absent calf bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "entite moleculaire" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002991 ; owl:annotatedTarget "An anomaly of the calf bone (fibula), one of the two bones of the calf." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002991 ; owl:annotatedTarget "Abnormality of the calf bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002992 ; owl:annotatedTarget "Abnormality of the tibia (shinbone)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002992 ; owl:annotatedTarget "Abnormality of the shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002992 ; owl:annotatedTarget "Abnormality of the shinbone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002996 ; owl:annotatedTarget "Decreased elbow mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002996 ; owl:annotatedTarget "Limited elbow mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002996 ; owl:annotatedTarget "Limited elbow movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002996 ; owl:annotatedTarget "Restricted elbow motion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23367 ; owl:annotatedTarget "molekulare Entitaet" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0002999 ; owl:annotatedTarget "The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar dislocation occurs if the patella fully dislocates out of the groove." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0002999 ; owl:annotatedTarget "Dislocated kneecap" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003001 ; owl:annotatedTarget "Glomus jugular tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003001 ; owl:annotatedTarget "Glomus jugulare tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23443 ; owl:annotatedTarget "cyclic amide" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003001 ; owl:annotatedTarget "Glomus jugulare tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003002 ; owl:annotatedTarget "The presence of a carcinoma of the breast." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003002 ; owl:annotatedTarget "Breast cancer" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003003 ; owl:annotatedTarget "Colon cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003005 ; owl:annotatedTarget "A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum, representing a tumor of the sympathetic nerve fibers arising from neural crest cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003006 ; owl:annotatedTarget "Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003006 ; owl:annotatedTarget "Cancer of early nerve cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003010 ; owl:annotatedTarget "Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003010 ; owl:annotatedTarget "Prolonged bleeding time" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "CAS:302-11-4" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23443 ; owl:annotatedTarget "cyclic amides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003011 ; owl:annotatedTarget "Abnormality originating in one or more muscles, i.e., of the set of muscles of body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003011 ; owl:annotatedTarget "Muscular abnormality" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003013 ; owl:annotatedTarget "A morphological abnormality of epiphyses whereby they are abnormally outwardly curving (protuberant)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003013 ; owl:annotatedTarget "Bulging end part of bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23449 ; owl:annotatedTarget "Cyclopeptid" . [] oboInOwl:hasDbXref , "PMID:12853662" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003015 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003015 ; owl:annotatedTarget "Flared wide portion of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23449 ; owl:annotatedTarget "Zyklopeptid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003016 ; owl:annotatedTarget "Abnormal widening of the metaphyseal regions of long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003016 ; owl:annotatedTarget "Broad wide portion of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23449 ; owl:annotatedTarget "cyclic peptides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003019 ; owl:annotatedTarget "Abnormality of the wrist, the structure connecting the hand and the forearm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003019 ; owl:annotatedTarget "Abnormalities of the wrists" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003019 ; owl:annotatedTarget "Abnormality of the wrist" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003020 ; owl:annotatedTarget "Enlargement of the wrists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003021 ; owl:annotatedTarget "Metaphyseal cupping refers to an inward bulging of the metaphyseal profile giving the metaphysis a cup-like appearance." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23449 ; owl:annotatedTarget "peptide cyclique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003022 ; owl:annotatedTarget "Underdevelopment of the ulna." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003022 ; owl:annotatedTarget "Underdeveloped inner large forearm bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003022 ; owl:annotatedTarget "Underdeveloped ulna" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23449 ; owl:annotatedTarget "peptido ciclico" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003023 ; owl:annotatedTarget "Curvature of the shafts of the long bones due to multiple fractures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003025 ; owl:annotatedTarget "Irregularity of the normally smooth surface of the metaphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003025 ; owl:annotatedTarget "Irregular wide portion of a long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003026 ; owl:annotatedTarget "One or more abnormally short long bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003026 ; owl:annotatedTarget "Long bone shortening" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003026 ; owl:annotatedTarget "Short long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23509 ; owl:annotatedTarget "cysteine derivative" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003027 ; owl:annotatedTarget "Shortening of the middle parts of the limbs (forearm and lower leg) in relation to the upper and terminal segments." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003027 ; owl:annotatedTarget "Disproportionately short middle portion of limb" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003028 ; owl:annotatedTarget "Abnormality of the ankles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23509 ; owl:annotatedTarget "cysteine derivatives" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003029 ; owl:annotatedTarget "Enlargement of the ankles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23622 ; owl:annotatedTarget "deoxygalactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003031 ; owl:annotatedTarget "Bending of the diaphysis (shaft) of the ulna." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003031 ; owl:annotatedTarget "Curving of inner forearm bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "Gmelin:239604" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23622 ; owl:annotatedTarget "deoxygalactoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003034 ; owl:annotatedTarget "An elevation in bone density in one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003034 ; owl:annotatedTarget "Increased bone density in shaft of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23628 ; owl:annotatedTarget "deoxyhexose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003037 ; owl:annotatedTarget "Increase in size of one or more joints." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003037 ; owl:annotatedTarget "Enlarged joints" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23628 ; owl:annotatedTarget "deoxyhexoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003038 ; owl:annotatedTarget "Underdevelopment of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003038 ; owl:annotatedTarget "Short calf bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003040 ; owl:annotatedTarget "Disease of the joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003041 ; owl:annotatedTarget "An abnormal osseous union (fusion) between the radius and the humerus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23639 ; owl:annotatedTarget "deoxy sugars" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003041 ; owl:annotatedTarget "Fusion of upper and lower arm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23639 ; owl:annotatedTarget "deoxysugar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003042 ; owl:annotatedTarget "Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003042 ; owl:annotatedTarget "Dislocations of the elbows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003042 ; owl:annotatedTarget "Elbow dislocation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003042 ; owl:annotatedTarget "Elbow dislocations" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23639 ; owl:annotatedTarget "deoxysugars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003043 ; owl:annotatedTarget "An abnormality of the shoulder, which is defined as the structures surrounding the shoulder joint where the humerus attaches to the scapula." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003043 ; owl:annotatedTarget "Abnormality of the shoulder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23677 ; owl:annotatedTarget "diazoles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003044 ; owl:annotatedTarget "Chronic reduction in active and passive mobility of the shoulder joint due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23690 ; owl:annotatedTarget "dicarboxylic acid amides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003045 ; owl:annotatedTarget "Abnormality of the patella (knee cap)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003045 ; owl:annotatedTarget "Abnormal kneecap" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23824 ; owl:annotatedTarget "diols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003048 ; owl:annotatedTarget "Partial dislocation of the head of the radius." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "carbamate" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23849 ; owl:annotatedTarget "LIPID_MAPS_class:LMPR0104" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003051 ; owl:annotatedTarget "Abnormal increase in size of one or more metaphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003051 ; owl:annotatedTarget "Enlarged wide portion of a long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003057 ; owl:annotatedTarget "Amelia of all four limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003057 ; owl:annotatedTarget "Tetra-amelia" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23849 ; owl:annotatedTarget "diterpenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003063 ; owl:annotatedTarget "An abnormality of the humerus (i.e., upper arm bone)." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23849 ; owl:annotatedTarget "C20 isoprenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003065 ; owl:annotatedTarget "Underdevelopment of the patella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003065 ; owl:annotatedTarget "Small kneecap" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003065 ; owl:annotatedTarget "Underdeveloped kneecap" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003066 ; owl:annotatedTarget "Limited knee extension" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23849 ; owl:annotatedTarget "diterpenoides" . [] oboInOwl:hasDbXref , "PMID:12362035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003067 ; owl:annotatedTarget "An anomaly related to partial closure, or failure of development of the ulnar side of the distal radial growth plate, which results in an arrest of epiphyseal growth of the medial and volar portions of the distal radius. This leads to shortening of the radius and relative overgrowth of the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003071 ; owl:annotatedTarget "Abnormal flatness (decreased height) of epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003071 ; owl:annotatedTarget "Flat end part of bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23888 ; owl:annotatedTarget "drugs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23888 ; owl:annotatedTarget "medicine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003072 ; owl:annotatedTarget "An abnormally increased calcium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003072 ; owl:annotatedTarget "High blood calcium levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003072 ; owl:annotatedTarget "Increased calcium in blood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003073 ; owl:annotatedTarget "Reduction in the concentration of albumin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003073 ; owl:annotatedTarget "Low albumin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003073 ; owl:annotatedTarget "Low blood albumin" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "LIPID_MAPS_class:LMFA03" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003074 ; owl:annotatedTarget "An increased concentration of glucose in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "PMID:12697726" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003074 ; owl:annotatedTarget "High blood glucose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003074 ; owl:annotatedTarget "High blood sugar" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "PMID:16107763" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003075 ; owl:annotatedTarget "A decreased concentration of protein in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003075 ; owl:annotatedTarget "Decreased protein levels in blood" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "carbamate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "PMID:19160658" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003076 ; owl:annotatedTarget "An increased concentration of glucose in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003076 ; owl:annotatedTarget "Glucose in urine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "PMID:2657063" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003077 ; owl:annotatedTarget "An elevated lipid concentration in the blood." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "icosanoid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003077 ; owl:annotatedTarget "Elevated lipids in blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "eicosanoid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003080 ; owl:annotatedTarget "An increased concentration of 4-hydroxy-L-proline in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003080 ; owl:annotatedTarget "Elevated urinary hydroxyproline" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "eicosanoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003081 ; owl:annotatedTarget "An increased concentration of potassium(1+) in the urine." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003081 ; owl:annotatedTarget "Increased urinary K" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003081 ; owl:annotatedTarget "Increased urinary potassium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23899 ; owl:annotatedTarget "icosanoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003083 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003083 ; owl:annotatedTarget "Dislocated radial heads" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23905 ; owl:annotatedTarget "monoatomic anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003084 ; owl:annotatedTarget "An increased tendency to fractures of the long bones (Mainly, the femur, tibia, fibula, humerus, radius, and ulna)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23906 ; owl:annotatedTarget "monoatomic cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003085 ; owl:annotatedTarget "Disproportionately long fibulae." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003085 ; owl:annotatedTarget "Long calf bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003085 ; owl:annotatedTarget "Long fibula" . [] oboInOwl:hasDbXref , "PMID:22286749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003086 ; owl:annotatedTarget "Small hands and feet." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "enzyme inhibitor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003088 ; owl:annotatedTarget "Premature arthritis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003088 ; owl:annotatedTarget "Premature osteoarthritis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003089 ; owl:annotatedTarget "Hamstring contractures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "enzyme inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003090 ; owl:annotatedTarget "Underdevelopment of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003090 ; owl:annotatedTarget "Small innermost thighbone end part" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003090 ; owl:annotatedTarget "Underdevelopment of the innermost thighbone end part" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003091 ; owl:annotatedTarget "Trophic changes occurring in a limb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003093 ; owl:annotatedTarget "Limitation of the extension of the hip, i.e., decreased ability to straighten the hip joint and thereby increase the angle between torso and thigh; moving the thigh or top of the pelvis backward." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003093 ; owl:annotatedTarget "Limited hip extension" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003093 ; owl:annotatedTarget "Restricted hip extension" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "Carbamat" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "inhibidor enzimatico" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003095 ; owl:annotatedTarget "Infected joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003097 ; owl:annotatedTarget "An abnormal shortening of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003097 ; owl:annotatedTarget "Short thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "inhibidores enzimaticos" . [] oboInOwl:hasDbXref , "PMID:17259417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003099 ; owl:annotatedTarget "Relatively increased growth of the fibula compared to that of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003099 ; owl:annotatedTarget "Overgrowth of calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "inhibiteur enzymatique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003100 ; owl:annotatedTarget "Reduced diameter of a long bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003100 ; owl:annotatedTarget "Long bones slender" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003100 ; owl:annotatedTarget "Slender long bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003100 ; owl:annotatedTarget "Thin long bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23924 ; owl:annotatedTarget "inhibiteurs enzymatiques" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003100 ; owl:annotatedTarget "Slender long bones" . [] oboInOwl:hasDbXref , "PMID:18506557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003102 ; owl:annotatedTarget "An abnormal increase in the carrying angle, which is the angle he long axis of the extended forearm as it lies lateral to the long axis of the arm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003103 ; owl:annotatedTarget "An abnormality of compact bone (also known as cortical bone), which forms the dense surface of bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003105 ; owl:annotatedTarget "The presence of multiple protuberances (bulges, or knobs) at the ends of the long bones." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003105 ; owl:annotatedTarget "Protuberances at ends of long bones" . [] oboInOwl:hasDbXref "PMID:24849102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003106 ; owl:annotatedTarget "Loss of bone mass occurring beneath the periosteum (the periosteum is the connective-tissue membrane that surrounds all bones except at the articular surfaces). This process may create a serrated and lace-like appearance in periosteal cortical bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003107 ; owl:annotatedTarget "Abnormality of cholesterol metabolism" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:18901181", "PMID:20240447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003108 ; owl:annotatedTarget "An increased concentration of glycine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003108 ; owl:annotatedTarget "High urine glycine levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23965 ; owl:annotatedTarget "PMID:10696569" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003109 ; owl:annotatedTarget "An increased excretion of phosphates in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003109 ; owl:annotatedTarget "High urine phosphate levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23965 ; owl:annotatedTarget "PMID:24084694" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003110 ; owl:annotatedTarget "An abnormality of the composition of urine or the levels of its components." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003110 ; owl:annotatedTarget "Pee issues" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23965 ; owl:annotatedTarget "estra-1,3,5(10)-triene-3,17-diol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003110 ; owl:annotatedTarget "Urine issues" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "Karbamat" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23965 ; owl:annotatedTarget "oestradiol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003111 ; owl:annotatedTarget "Abnormality of the homeostasis (concentration) of a monoatomic ion." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003111 ; owl:annotatedTarget "Electrolyte disorders" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23966 ; owl:annotatedTarget "Beilstein:3125721" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003112 ; owl:annotatedTarget "The presence of an abnormal decrease or increase of one or more amino acids in the blood circulation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003112 ; owl:annotatedTarget "Abnormality of serum amino acid levels" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_23966 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02010000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003113 ; owl:annotatedTarget "An abnormally decreased chloride concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003113 ; owl:annotatedTarget "Low blood chloride levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_23966 ; owl:annotatedTarget "estrane" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003115 ; owl:annotatedTarget "Abnormal ECG" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003115 ; owl:annotatedTarget "Abnormal EKG" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003115 ; owl:annotatedTarget "EKG abnormality" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23966 ; owl:annotatedTarget "Oestran" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003117 ; owl:annotatedTarget "Concentration of a hormone in the blood circulation outside of normal limits." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003117 ; owl:annotatedTarget "Abnormality of circulating hormone level" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23966 ; owl:annotatedTarget "oestrane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003118 ; owl:annotatedTarget "Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_23981 ; owl:annotatedTarget "ethanolamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003118 ; owl:annotatedTarget "Hypercortisolism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003118 ; owl:annotatedTarget "Increased circulating cortisol level" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "PMID:31838543" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003119 ; owl:annotatedTarget "Any deviation from the normal concentration of a lipid in the blood circulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003119 ; owl:annotatedTarget "Dyslipidaemia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "PMID:32057251" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003121 ; owl:annotatedTarget "A contracture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003121 ; owl:annotatedTarget "Limb contractures" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "PMID:33549284" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003124 ; owl:annotatedTarget "An increased concentration of cholesterol in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003124 ; owl:annotatedTarget "High cholesterol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003124 ; owl:annotatedTarget "Elevated serum cholesterol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003124 ; owl:annotatedTarget "Elevated total cholesterol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003124 ; owl:annotatedTarget "Increased total cholesterol" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "carbamate ion" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "PMID:34045883" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003125 ; owl:annotatedTarget "Reduced activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X." . [] oboInOwl:hasDbXref "PMID:95574" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003126 ; owl:annotatedTarget "Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "fat-soluble vitamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003127 ; owl:annotatedTarget "An abnormally decreased calcium concentration in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003127 ; owl:annotatedTarget "Low urine calcium levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "fat-soluble vitamins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003128 ; owl:annotatedTarget "An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003128 ; owl:annotatedTarget "Increased lactate in body" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24020 ; owl:annotatedTarget "fettloesliche Vitamine" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:jbaets" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003130 ; owl:annotatedTarget "An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003131 ; owl:annotatedTarget "An increased concentration of cystine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003131 ; owl:annotatedTarget "High urine cystine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003133 ; owl:annotatedTarget "An abnormality of the spinocerebellar tracts, a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. The spinocerebellar tract convey information to the cerebellum about limb and joint position (proprioception). They comprise the ventral spinocerebellar tract, the anterior spinocerebellar tract, and the posterior spinocerebellar tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003134 ; owl:annotatedTarget "An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24149 ; owl:annotatedTarget "PMID:14680973" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003137 ; owl:annotatedTarget "Level of proline in the urine anove the upper limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24163 ; owl:annotatedTarget "galactoside" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24163 ; owl:annotatedTarget "galactosides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003138 ; owl:annotatedTarget "An increased amount of nitrogen in the form of urea in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003138 ; owl:annotatedTarget "Increased BUN" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003138 ; owl:annotatedTarget "Increased blood urea nitrogen" . [] oboInOwl:hasDbXref "PMID:23726535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003139 ; owl:annotatedTarget "A reduction in the circulating levels of all the major classes of immunoglobulin. is characterized by profound decreases in all classes of immunoglobulin with an absence of circulating B lymphocytes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003139 ; owl:annotatedTarget "Panhypogammaglobulinaemia" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_13941 ; owl:annotatedTarget "carbamic acid, ion(1-)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24261 ; owl:annotatedTarget "glucocorticoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003141 ; owl:annotatedTarget "An elevated concentration of low-density lipoprotein cholesterol in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003141 ; owl:annotatedTarget "Increased LDL cholesterol" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003141 ; owl:annotatedTarget "Increased LDLc concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003141 ; owl:annotatedTarget "Increased circulating LDL level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003141 ; owl:annotatedTarget "Increased plasma LDL levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24280 ; owl:annotatedTarget "D-glucopyranosyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003144 ; owl:annotatedTarget "A increased concentration of serotonin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003144 ; owl:annotatedTarget "Increased serum serotonin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24280 ; owl:annotatedTarget "D-glucopyranosyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003145 ; owl:annotatedTarget "Decreased concentration of adenosylcobalamin. Adenosylcobalamin is one of the active forms of vitamin B12." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24280 ; owl:annotatedTarget "glucopyranosyl group" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003146 ; owl:annotatedTarget "An decreased concentration of cholesterol in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003146 ; owl:annotatedTarget "Decreased circulating cholesterol level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003148 ; owl:annotatedTarget "Acid phosphatase elevated" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003148 ; owl:annotatedTarget "Elevated serum acid phosphatase" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24280 ; owl:annotatedTarget "glucosyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003149 ; owl:annotatedTarget "An abnormally high level of uric acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003149 ; owl:annotatedTarget "High urine uric acid level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24281 ; owl:annotatedTarget "glucosyl groups" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003150 ; owl:annotatedTarget "The concentration of glutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003150 ; owl:annotatedTarget "Glutarate aciduria" . [] oboInOwl:hasDbXref , "CHEBI:24329" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003150 ; owl:annotatedTarget "Increased glutarate level in urine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24318 ; owl:annotatedTarget "PMID:20716061" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003153 ; owl:annotatedTarget "An elevated urinary concentration of cystathionine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003153 ; owl:annotatedTarget "High urine cystathionine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24318 ; owl:annotatedTarget "glutamine family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003154 ; owl:annotatedTarget "An abnormal increased in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003154 ; owl:annotatedTarget "High blood corticotropin levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "PMID:15326516" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003154 ; owl:annotatedTarget "Increased circulating ACTH level" . [] oboInOwl:hasDbXref , "PMID:29083622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Abnormally increased serum levels of alkaline phosphatase activity." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Elevated ALP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "EC 6.3.1.2 inhibitor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Elevated alkaline phosphatase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Greatly elevated alkaline phosphatase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "High serum alkaline phosphatase" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Hyperphosphatasia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Increased alkaline phosphatase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003155 ; owl:annotatedTarget "Increased serum alkaline phosphatase" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003158 ; owl:annotatedTarget "An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "EC 6.3.1.2 inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003159 ; owl:annotatedTarget "Increased excretion of oxalates in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003159 ; owl:annotatedTarget "High urine oxalate levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "L-glutamate:ammonia ligase (ADP-forming) inhibitor" . [] oboInOwl:hasDbXref , , "PMID:11135054" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003159 ; owl:annotatedTarget "Increased level of oxalate in urine" . [] oboInOwl:hasDbXref , "PMID:22516080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003160 ; owl:annotatedTarget "Glycosylated transferrin concentrations can be measured in serum as a marker of N-linked glycosylation fidelity. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II. These terms are retained for historical reasons but for new annotations the precise glycosylation defect should be recorded." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "L-glutamate:ammonia ligase (ADP-forming) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003161 ; owl:annotatedTarget "Increased relative concentration of 4-hydroxyphenylpyruvic acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003162 ; owl:annotatedTarget "Low blood sugar when fasting" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "L-glutamine synthetase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003163 ; owl:annotatedTarget "An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003163 ; owl:annotatedTarget "Elevated urinary delta-aminolevulinic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "L-glutamine synthetase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003165 ; owl:annotatedTarget "An abnormal increased concentration of parathyroid hormone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamate--ammonia ligase (EC 6.3.1.2) inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamate--ammonia ligase (EC 6.3.1.2) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003166 ; owl:annotatedTarget "Increased concentration of taurine in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003166 ; owl:annotatedTarget "Increased urinary taurine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamate--ammonia ligase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003167 ; owl:annotatedTarget "An increased concentration of carnosine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003167 ; owl:annotatedTarget "High urine carnosine levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "PMID:19908854" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamate--ammonia ligase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003170 ; owl:annotatedTarget "An abnormality of the acetabulum, i.e., the Acetabular part of hip bone, which together with the head of the femur forms the hip joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003170 ; owl:annotatedTarget "Abnormality of the hipbone socket" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamine synthetase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003172 ; owl:annotatedTarget "An anomaly of the the pubic bone, i.e., of the ventral and anterior of the three principal components (pubis, ilium, ischium) of the hip bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003172 ; owl:annotatedTarget "Abnormality of the pubic bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003172 ; owl:annotatedTarget "Abnormality of the pubic bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003172 ; owl:annotatedTarget "Abnormality of the pubis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamine synthetase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003173 ; owl:annotatedTarget "Underdevelopment of the pubis, which together with the ilium and the ischium, is one of the three bones that make up the hip bone." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003173 ; owl:annotatedTarget "Hypoplastic pubic bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamylhydroxamic synthetase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003174 ; owl:annotatedTarget "An anomaly of the ischium, which forms the lower and back part of the hip bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24319 ; owl:annotatedTarget "glutamylhydroxamic synthetase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003175 ; owl:annotatedTarget "Underdevelopment of the ischium, which forms the lower and back part of the hip bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003177 ; owl:annotatedTarget "A shift from the normally round (convex) appearance of the iliac wing towards a square-like appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003179 ; owl:annotatedTarget "Intrapelvic bulging of the medial acetabular wall." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003179 ; owl:annotatedTarget "Abnormally indented hip sockets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003180 ; owl:annotatedTarget "Flattening of the superior part of the acetabulum, which is a cup-shaped cavity at the base of the hipbone into which the ball-shaped head of the femur fits. The acetabular roof thereby appears horizontal rather than arched, as it normally does." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24329 ; owl:annotatedTarget "glutarate anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24329 ; owl:annotatedTarget "glutarates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003183 ; owl:annotatedTarget "Abnormally increased width of the pubic symphysis is the midline cartilaginous joint uniting the superior rami of the left and right pubic bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003184 ; owl:annotatedTarget "Reduced ability to move the femur outward to the side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003185 ; owl:annotatedTarget "The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a reduction in the height of the notch." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24329 ; owl:annotatedTarget "glutaric acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003186 ; owl:annotatedTarget "The presence of nipples that instead of pointing outward are retracted inwards." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003186 ; owl:annotatedTarget "Invaginated nipples" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003186 ; owl:annotatedTarget "Inverted nipples" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003187 ; owl:annotatedTarget "Underdevelopment of the breast." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003187 ; owl:annotatedTarget "Underdeveloped breasts" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "PMID:20382022" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24396 ; owl:annotatedTarget "glycopeptides" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Distance from nasion to subnasale more than two standard deviations above the mean, or alternatively, an apparently increased length from the nasal root to the nasal base." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Elongated nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Increased height of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Increased length of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Increased nasal height" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Increased nasal length" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Long nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003189 ; owl:annotatedTarget "Nasal elongation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24400 ; owl:annotatedTarget "glycosides" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003191 ; owl:annotatedTarget "The presence of a notch in the margin of the ala nasi." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003191 ; owl:annotatedTarget "Cleft nasal alae" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003191 ; owl:annotatedTarget "Cleft nostril" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24400 ; owl:annotatedTarget "O-glycoside" . [] oboInOwl:hasDbXref "PMID:11449200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003193 ; owl:annotatedTarget "It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003193 ; owl:annotatedTarget "Hay fever" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003193 ; owl:annotatedTarget "Hayfever" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003193 ; owl:annotatedTarget "Nasal allergies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24400 ; owl:annotatedTarget "O-glycosides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003194 ; owl:annotatedTarget "Decreased length of bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003194 ; owl:annotatedTarget "Decreased length of nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003194 ; owl:annotatedTarget "Short bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003194 ; owl:annotatedTarget "Short nasal bridge" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24400 ; owl:annotatedTarget "glycosides" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003196 ; owl:annotatedTarget "Distance from nasion to subnasale more than two standard deviations below the mean, or alternatively, an apparently decreased length from the nasal root to the nasal tip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003196 ; owl:annotatedTarget "Decreased length of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003196 ; owl:annotatedTarget "Short nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003196 ; owl:annotatedTarget "Shortened nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003196 ; owl:annotatedTarget "Small nose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:18845618" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003198 ; owl:annotatedTarget "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003198 ; owl:annotatedTarget "Muscle tissue disease" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:19303901" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003199 ; owl:annotatedTarget "Decreased muscle mass" . [] oboInOwl:hasDbXref , "PMID:12075011", "PMID:16537564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003200 ; owl:annotatedTarget "An abnormal appearance of muscle fibers observed on muscle biopsy. Ragged red fibers can be visualized with Gomori trichrome staining as irregular and intensely red subsarcolemmal zones, whereas the normal myofibrils are green. The margins of affect fibers appear red and ragged. The ragged-red is due to the accumulation of abnormal mitochondria below the plasma membrane of the muscle fiber, leading to the appearance of a red rim and speckled sarcoplasm." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003200 ; owl:annotatedTarget "Ragged red muscle fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003200 ; owl:annotatedTarget "Ragged-red fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003200 ; owl:annotatedTarget "Ragged-red muscle fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003201 ; owl:annotatedTarget "Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003201 ; owl:annotatedTarget "Breakdown of skeletal muscle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:26954668" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003202 ; owl:annotatedTarget "The presence of skeletal muscular atrophy (which is also known as amyotrophy)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003202 ; owl:annotatedTarget "Muscle degeneration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003202 ; owl:annotatedTarget "Muscle wasting" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:26976737" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003203 ; owl:annotatedTarget "In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria." . [] oboInOwl:hasDbXref , "PMID:16455164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003204 ; owl:annotatedTarget "The intracellular accumulation of autofluorescent storage material." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003205 ; owl:annotatedTarget "An intracellular accumulation of autofluorescent lipopigment storage material in a curved pattern." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:27253729" . [] oboInOwl:hasDbXref , "PMID:18519861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003207 ; owl:annotatedTarget "Pathological deposition of calcium salts in one or more arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003208 ; owl:annotatedTarget "An intracellular accumulation of autofluorescent lipopigment storage material in a trabecular or fingerprint-like pattern." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003209 ; owl:annotatedTarget "A decreased rate of pyruvate carboxylase activity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "PMID:23295224" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "PMID:27325407" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003210 ; owl:annotatedTarget "An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24402 ; owl:annotatedTarget "glycosphingolipids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003212 ; owl:annotatedTarget "An abnormally increased overall level of immunoglobulin E in blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24403 ; owl:annotatedTarget "glycosyl group" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24403 ; owl:annotatedTarget "glycosyl groups" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003215 ; owl:annotatedTarget "An increased concentration of dicarboxylic acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003216 ; owl:annotatedTarget "A diffuse form of amyloidosis." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24403 ; owl:annotatedTarget "groupe glycosyle" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003216 ; owl:annotatedTarget "Generalised amyloid deposition" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24431 ; owl:annotatedTarget "chemical entity" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:4696900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003217 ; owl:annotatedTarget "An increased concentration of glutamine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003217 ; owl:annotatedTarget "High plasma glutamine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24432 ; owl:annotatedTarget "biological function" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarlotti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003218 ; owl:annotatedTarget "An increased concentration of orotic acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003218 ; owl:annotatedTarget "High urine orotic acid levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003218 ; owl:annotatedTarget "Orotic aciduria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003219 ; owl:annotatedTarget "The concentration of ethylmalonic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003220 ; owl:annotatedTarget "A type of chromosomal aberration characterised by reduced resistance of chromosomes to change or deterioration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003221 ; owl:annotatedTarget "Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with DNA cross-linking agents such as diepoxybutane and mitomycin C." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003223 ; owl:annotatedTarget "Decreased concentration of methylcobalamin. Methylcobalamin is a form of vitamin B12." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "Gruppe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003225 ; owl:annotatedTarget "Decreased activity of coagulation factor V." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003226 ; owl:annotatedTarget "An intracellular accumulation of autofluorescent lipopigment storage material in a straight or rectilinear pattern." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "alpha-hydroxy ketones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "Rest" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003228 ; owl:annotatedTarget "An abnormally increased sodium concentration in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003228 ; owl:annotatedTarget "High blood sodium levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "groupe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003231 ; owl:annotatedTarget "An increased concentration of tyrosine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003231 ; owl:annotatedTarget "Increased tyrosine in blood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003232 ; owl:annotatedTarget "Decreased mitochondrial malic enzyme" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "grupo" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24433 ; owl:annotatedTarget "grupos" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003233 ; owl:annotatedTarget "An decreased concentration of high-density lipoprotein cholesterol in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003233 ; owl:annotatedTarget "Decreased HDL cholesterol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003233 ; owl:annotatedTarget "Decreased circulating high-density lipoprotein cholesterol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003233 ; owl:annotatedTarget "Low HDL-cholesterol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24470 ; owl:annotatedTarget "haloamino acids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003234 ; owl:annotatedTarget "A decreased concentration of carnitine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003234 ; owl:annotatedTarget "Decreased plasma carnitine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003234 ; owl:annotatedTarget "Carnitine deficiency" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003235 ; owl:annotatedTarget "An increased concentration of methionine in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24471 ; owl:annotatedTarget "halogen molecular entity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003235 ; owl:annotatedTarget "Increased methionine in blood" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24471 ; owl:annotatedTarget "halogen compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood. CK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated blood creatine phosphokinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated circulating creatine phosphokinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated creatine kinase" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated serum CPK" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated serum creatine kinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Elevated serum creatine phosphokinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "High serum creatine kinase" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24471 ; owl:annotatedTarget "halogen molecular entities" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased CPK" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased creatine kinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased creatine phosphokinase" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased serum CK" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased serum creatine kinase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003236 ; owl:annotatedTarget "Increased serum creatine phosphokinase" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003237 ; owl:annotatedTarget "An abnormally increased level of immunoglobulin G in blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "alpha-hydroxy-ketone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogens" . [] oboInOwl:hasDbXref , "PMID:23093139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003239 ; owl:annotatedTarget "An increased level of phosphoethanolamine (synonym: O-phosphoethanolamine) in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "Halogene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003239 ; owl:annotatedTarget "High urine phosphoethanolamine levels" . [] oboInOwl:hasDbXref "PMID:4200723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003240 ; owl:annotatedTarget "Abnormally elevated level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003241 ; owl:annotatedTarget "Underdevelopment of part or all of the external reproductive organs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "group 17 elements" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003241 ; owl:annotatedTarget "Underdevelopment of external reproductive organs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "group VII elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003244 ; owl:annotatedTarget "Location of the urethral opening on the inferior aspect of the penis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003246 ; owl:annotatedTarget "Increased size of the ridge of tissue that extends along the midline of the scrotum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogene" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003247 ; owl:annotatedTarget "Overgrowth of external genitalia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003249 ; owl:annotatedTarget "Genital ulcers" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003250 ; owl:annotatedTarget "Aplasia of the vagina." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003250 ; owl:annotatedTarget "Absent vagina" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogeno" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003251 ; owl:annotatedTarget "Male infertility" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24473 ; owl:annotatedTarget "halogenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003254 ; owl:annotatedTarget "An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24500 ; owl:annotatedTarget "heparans" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003256 ; owl:annotatedTarget "An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24532 ; owl:annotatedTarget "organic heterocycle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "alpha-hydroxy-ketones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24532 ; owl:annotatedTarget "organic heterocyclic compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003259 ; owl:annotatedTarget "An increased amount of creatinine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003259 ; owl:annotatedTarget "Elevated creatinine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003259 ; owl:annotatedTarget "High blood creatinine level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003259 ; owl:annotatedTarget "Increased creatinine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003259 ; owl:annotatedTarget "Increased serum creatinine" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24533 ; owl:annotatedTarget "heterodetic cyclic peptide" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003260 ; owl:annotatedTarget "An increased concentration of hydroxyproline in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24533 ; owl:annotatedTarget "heterodetic cyclic peptides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003260 ; owl:annotatedTarget "High blood hydroxyproline levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24533 ; owl:annotatedTarget "peptide cyclique heterodetique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003261 ; owl:annotatedTarget "An abnormally increased level of immunoglobulin A in blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003262 ; owl:annotatedTarget "The presence in serum of antibodies against smooth muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003265 ; owl:annotatedTarget "A type of hyperbilirubinemia with neonatal onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003265 ; owl:annotatedTarget "High blood bilirubin levels in neonate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24533 ; owl:annotatedTarget "peptido ciclico heterodetico" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003267 ; owl:annotatedTarget "An abnormal decrease in orotidine 5'-phosphate decarboxylase level." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24583 ; owl:annotatedTarget "hexitol" . [] oboInOwl:hasDbXref , "PMID:18901181", "PMID:20240447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003268 ; owl:annotatedTarget "A increased concentration of arginine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003268 ; owl:annotatedTarget "High urine arginine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24583 ; owl:annotatedTarget "hexitols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003270 ; owl:annotatedTarget "Distention of the abdomen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003270 ; owl:annotatedTarget "Abdominal bloating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003270 ; owl:annotatedTarget "Abdominal swelling" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003270 ; owl:annotatedTarget "Belly bloating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003270 ; owl:annotatedTarget "Bloating" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003271 ; owl:annotatedTarget "Abnormal increased size of the viscera of the abdomen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003272 ; owl:annotatedTarget "An abnormality of the hip bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003272 ; owl:annotatedTarget "Abnormality of the hip bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003272 ; owl:annotatedTarget "Abnormality of the hips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24599 ; owl:annotatedTarget "histidine derivatives" . [] oboInOwl:hasDbXref "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003273 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the hip joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "alpha-hydroxyketone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24621 ; owl:annotatedTarget "endocrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003274 ; owl:annotatedTarget "Underdeveloped acetabulae." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24621 ; owl:annotatedTarget "hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003275 ; owl:annotatedTarget "Reduced side to side width of the pelvis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003275 ; owl:annotatedTarget "Narrow pelvis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003275 ; owl:annotatedTarget "Narrow pelvis bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003276 ; owl:annotatedTarget "A benign growth the projects outward from the bone surface of the pelvis. Exostoses are capped by cartilage, and arise from a bone that develops from cartilage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003276 ; owl:annotatedTarget "Pelvic exostoses" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "hydrocarbon" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003277 ; owl:annotatedTarget "Constricted iliac wings" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "hydrocarbons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003278 ; owl:annotatedTarget "An abnormally squared appearance of the bony pelvis, a normally rounded or basin-shaped structure." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003278 ; owl:annotatedTarget "Square pelvis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003278 ; owl:annotatedTarget "Square pelvis bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003279 ; owl:annotatedTarget "Widening of the femoral head and neck." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "Kohlenwasserstoff" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003281 ; owl:annotatedTarget "Increased concentration of ferritin in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "Kohlenwasserstoffe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003281 ; owl:annotatedTarget "Elevated serum ferritin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003281 ; owl:annotatedTarget "High ferritin level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003281 ; owl:annotatedTarget "Increased ferritin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003281 ; owl:annotatedTarget "Increased serum ferritin level" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "hidrocarburo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003282 ; owl:annotatedTarget "Abnormally reduced serum levels of alkaline phosphatase." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003282 ; owl:annotatedTarget "Decreased serum alkaline phosphatase" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003282 ; owl:annotatedTarget "Low ALP" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "hidrocarburos" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:16902722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003286 ; owl:annotatedTarget "An increased concentration of cystathionine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003286 ; owl:annotatedTarget "High blood cystathionine levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24632 ; owl:annotatedTarget "hydrocarbure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003287 ; owl:annotatedTarget "A functional anomaly of mitochondria." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139588 ; owl:annotatedTarget "alpha-hydroxyketones" . [] oboInOwl:hasDbXref , "PMID:16932309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003292 ; owl:annotatedTarget "A decreased concentration of leptin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003292 ; owl:annotatedTarget "Decreased serum leptin" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24654 ; owl:annotatedTarget "LIPID_MAPS_class:LMFA0105" . [] oboInOwl:hasDbXref , "PMID:18901181", "PMID:20240447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003296 ; owl:annotatedTarget "An increased concentration of threonine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003296 ; owl:annotatedTarget "High urine threonine levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24654 ; owl:annotatedTarget "PMID:18296335" . [] oboInOwl:hasDbXref , "PMID:18901181", "PMID:20240447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003297 ; owl:annotatedTarget "An increased concentration of lysine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003297 ; owl:annotatedTarget "High urine lysine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003298 ; owl:annotatedTarget "The closed form of spina bifida with incomplete closure of a vertebral body with intact overlying skin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24654 ; owl:annotatedTarget "PMID:6419288" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003300 ; owl:annotatedTarget "When viewed in lateral radiographs, vertebral bodies have a roughly rectangular configuration. This term applies if the vertebral body appears rounded or oval." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24654 ; owl:annotatedTarget "PMID:8274032" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003301 ; owl:annotatedTarget "An irregular surface of the vertebral end plates, which are normally relatively smooth." . [] oboInOwl:hasDbXref , "PMID:20411054" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003302 ; owl:annotatedTarget "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003302 ; owl:annotatedTarget "Displacement of one backbone compared to another" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003302 ; owl:annotatedTarget "Slipped backbone" . [] oboInOwl:hasDbXref , "PMID:20440613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003304 ; owl:annotatedTarget "Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003305 ; owl:annotatedTarget "Congenital synostosis between two or more adjacent vertebrae (partial or complete fusion of adjacent vertabral bodies)." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24654 ; owl:annotatedTarget "hydroxy fatty acids" . [] oboInOwl:hasDbXref , "PMID:11601420", "PMID:2246660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003306 ; owl:annotatedTarget "Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003306 ; owl:annotatedTarget "Reduced spine movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003307 ; owl:annotatedTarget "Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003307 ; owl:annotatedTarget "Prominent swayback" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24663 ; owl:annotatedTarget "hydroxy-5beta-cholanic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003308 ; owl:annotatedTarget "A partial dislocation of one or more intervertebral joints in the cervical vertebral column." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24669 ; owl:annotatedTarget "hydroxy carboxylic acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24669 ; owl:annotatedTarget "hydroxycarboxylic acid" . [] oboInOwl:hasDbXref , "PMID:27081234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003310 ; owl:annotatedTarget "Abnormal structure of the odontoid process, which is a part of the C2 or axis vertebra and forms pivot of the structures forming the craniovertebral junction. The odontoid process is also known as the dens of the axis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24669 ; owl:annotatedTarget "hydroxycarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003311 ; owl:annotatedTarget "Developmental hypoplasia of the dens of the axis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003311 ; owl:annotatedTarget "Small odontoid peg" . [] oboInOwl:hasDbXref , "PMID:31448202", "PMID:3693103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003316 ; owl:annotatedTarget "A butterfly vertebra (sagittal cleft vertebra or anterior rachischisis) is a sagittal defect in the vertebral body caused by failure of fusion of the two lateral chondrification centers during embryogenesis. The name is based on the appearance of the two hemivertebrae emerging as butterfly wings from the central cleft on x-ray." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003316 ; owl:annotatedTarget "Butterfly vertebrae" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24684 ; owl:annotatedTarget "hydroxybutanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003319 ; owl:annotatedTarget "Any abnormality of the cervical vertebral column." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003319 ; owl:annotatedTarget "Abnormal cervical spine" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003319 ; owl:annotatedTarget "Abnormality of cervical vertebra" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003319 ; owl:annotatedTarget "Abnormality of the cervical vertebrae" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003319 ; owl:annotatedTarget "Cervical vertebral anomalies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24684 ; owl:annotatedTarget "hydroxybutanoic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003320 ; owl:annotatedTarget "A partial dislocation of the atlantoaxial joints." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24684 ; owl:annotatedTarget "hydroxybutyric acids" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24712 ; owl:annotatedTarget "hydroxymethyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003324 ; owl:annotatedTarget "Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003324 ; owl:annotatedTarget "Generalised muscle weakness" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003324 ; owl:annotatedTarget "Generalised weakness" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24712 ; owl:annotatedTarget "-CH2-OH" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003324 ; owl:annotatedTarget "Muscle weakness, generalised" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24712 ; owl:annotatedTarget "serine side-chain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003325 ; owl:annotatedTarget "Weakness of the limb-girdle muscles (also known as the pelvic and shoulder girdles), that is, lack of strength of the muscles around the shoulders and the pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003326 ; owl:annotatedTarget "Pain in muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003326 ; owl:annotatedTarget "Muscle ache" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003326 ; owl:annotatedTarget "Muscle pain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003326 ; owl:annotatedTarget "Myalgias" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24741 ; owl:annotatedTarget "hydroxyprolines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003327 ; owl:annotatedTarget "Reduced strength of the axial musculature (i.e., of the muscles of the head and neck, spine, and ribs)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003330 ; owl:annotatedTarget "Any anomaly in the composite material or the layered arrangement of the bony skeleton." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxoacid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003334 ; owl:annotatedTarget "An abnormal increase in catecholamine concentration in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxoacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003336 ; owl:annotatedTarget "An abnormality of the process of endochondral ossification, which is a type of replacement ossification in which bone tissue replaces cartilage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003337 ; owl:annotatedTarget "The prothrombin consumption test measures the formation of intrinsic thromboplastin by determining the residual serum prothrombin after blood clotting is complete. If there is a defect in the process, less prothrombin will be converted to thrombin than normal (less prothrombin is consumed). This test may be abnormal with conditions including deficiency of factors VIII or IX, with circulating anticoagulants, thrombocytopenia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003339 ; owl:annotatedTarget "A type of megaloblastic anemia that improves upon administration of pyrimidine supplements such as uridylic acid and cytidylic acid." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003339 ; owl:annotatedTarget "Anaemia corrected by uridylic acid and cytidylic acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003339 ; owl:annotatedTarget "Pyrimidine-responsive megaloblastic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003341 ; owl:annotatedTarget "The formation of bullae (blisters) with cleavage in the lamina lucida layer of the skin." . [] oboInOwl:hasDbXref "PMID:17397529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003343 ; owl:annotatedTarget "Reduced level of the enzyme glutathione synthetase, which catalyzes the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione. Acidosis is due to reduced feedback inhibition of gamma-glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxiacids" . [] oboInOwl:hasDbXref "PMID:19177531" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003344 ; owl:annotatedTarget "An abnormally increased level of 3-hydroxy-3-methylglutaric acid in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxo acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003345 ; owl:annotatedTarget "The concentration of noradrenaline in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003347 ; owl:annotatedTarget "Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxy-acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24833 ; owl:annotatedTarget "oxyacids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:16902722", "PMID:4696900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003348 ; owl:annotatedTarget "An increased concentration of alanine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003348 ; owl:annotatedTarget "Increased blood alanine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003348 ; owl:annotatedTarget "Increased serum alanine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24834 ; owl:annotatedTarget "inorganic anions" . [] oboInOwl:hasDbXref , "PMID:3378364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003349 ; owl:annotatedTarget "A reduction in the rate of cholesterol esterification." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24835 ; owl:annotatedTarget "anorganische Verbindungen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003351 ; owl:annotatedTarget "An decreased level of renin in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003352 ; owl:annotatedTarget "An increase in the number of chromosome sets per cell in bone marrow cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24835 ; owl:annotatedTarget "inorganic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003353 ; owl:annotatedTarget "An abnormality of amino acid metabolism characterized by a decreased level of propionyl-CoA carboxylase." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24835 ; owl:annotatedTarget "inorganic entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003354 ; owl:annotatedTarget "An increased concentration of threonine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003354 ; owl:annotatedTarget "High blood threonine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24835 ; owl:annotatedTarget "inorganic molecular entities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24835 ; owl:annotatedTarget "inorganics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003355 ; owl:annotatedTarget "An increased concentration of an amino acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003355 ; owl:annotatedTarget "High urine amino acid levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003355 ; owl:annotatedTarget "Increased levels of animo acids in urine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003355 ; owl:annotatedTarget "Abnormal urinary amino-acid findings" . [] oboInOwl:hasDbXref "PMID:7058086" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003357 ; owl:annotatedTarget "A reduction in the level of thymic horomone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24836 ; owl:annotatedTarget "inorganic oxides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003358 ; owl:annotatedTarget "An increased concentration of cystine within cells. This finding can be demonstrated on leukocytes, but is not specific to blood cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003359 ; owl:annotatedTarget "Decreased concentration of sulfate in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003359 ; owl:annotatedTarget "Decreased urinary sulfate" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003359 ; owl:annotatedTarget "Decreased urinary sulphate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "iodine" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti", "PMID:18901181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003361 ; owl:annotatedTarget "An increased concentration of tryptophan in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003361 ; owl:annotatedTarget "High urine tryptophan levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "53I" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003362 ; owl:annotatedTarget "An increase in the amount of very-low-density lipoprotein cholesterol in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003362 ; owl:annotatedTarget "Increased plasma VLDL cholesterol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003363 ; owl:annotatedTarget "A left-right reversal (or \"mirror reflection\") of the anatomical location of the viscera of the abdomen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003365 ; owl:annotatedTarget "Joint pain affecting the hip." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "I" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003365 ; owl:annotatedTarget "Hip joint pain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003366 ; owl:annotatedTarget "Abnormal neck or head of thigh bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003367 ; owl:annotatedTarget "An abnormality of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoid anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "Iod" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003367 ; owl:annotatedTarget "Abnormal neck of thigh bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003368 ; owl:annotatedTarget "An abnormality of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003368 ; owl:annotatedTarget "Abnormal head of thigh bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "J" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003370 ; owl:annotatedTarget "An abnormal flattening of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003370 ; owl:annotatedTarget "Flat end part of innermost thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "Jod" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003371 ; owl:annotatedTarget "An abnormal enlargement of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003371 ; owl:annotatedTarget "Enlarged end part of innermost thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "iode" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003375 ; owl:annotatedTarget "A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003375 ; owl:annotatedTarget "Narrow greater sacrosciatic notches" . [] oboInOwl:hasDbXref , "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003376 ; owl:annotatedTarget "An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003376 ; owl:annotatedTarget "High stepping" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003378 ; owl:annotatedTarget "A pattern of simultaneous degeneration and regeneration of axons (see comment)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "iodine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "iodium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003380 ; owl:annotatedTarget "A loss of myelinated nerve fibers in the peripheral nervous system (in general, this finding can be observed on nerve biopsy)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003380 ; owl:annotatedTarget "Decreased number of large and small myelinated fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003380 ; owl:annotatedTarget "Decreased number of peripheral myelinated nerve fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003380 ; owl:annotatedTarget "Loss of myelinated fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003383 ; owl:annotatedTarget "Repeated episodes of segmental demyelination and remyelination lead to the accumulation of supernumerary Schwann cells around axons, which is referred to as onion bulb formation. This finding affects peripheral nerves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003383 ; owl:annotatedTarget "Onion bulb formations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003384 ; owl:annotatedTarget "Atrophic changes of axons of the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003387 ; owl:annotatedTarget "A reduced number of large myelinated nerve fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003387 ; owl:annotatedTarget "Decreased number of large peripheral myelinated nerve fibres" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24859 ; owl:annotatedTarget "yodo" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003387 ; owl:annotatedTarget "Depletion of large myelinated fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003387 ; owl:annotatedTarget "Loss of large myelinated fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003387 ; owl:annotatedTarget "Loss of larger myelinated nerve fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003388 ; owl:annotatedTarget "Increased susceptibility to fatigue." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003388 ; owl:annotatedTarget "Tired easily" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003390 ; owl:annotatedTarget "An axonal neuropathy of peripheral sensory nerves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003391 ; owl:annotatedTarget "A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the proximal muscles of the lower limbs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24860 ; owl:annotatedTarget "iodine molecular entity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24860 ; owl:annotatedTarget "iodine compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003394 ; owl:annotatedTarget "Sudden and involuntary contractions of one or more muscles." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003394 ; owl:annotatedTarget "Muscle cramps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003396 ; owl:annotatedTarget "Dilated, glial-lined cavity in spinal cord. This cavity does not communicate with the central canal, and usually is between the dorsal columns unilaterally or bilaterally along the side of the cord." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003396 ; owl:annotatedTarget "Fluid-filled cyst in spinal cord" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003397 ; owl:annotatedTarget "Generalised hypotonia due to defect at the neuromuscular junction" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoid carboxylate anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24860 ; owl:annotatedTarget "iodine molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003398 ; owl:annotatedTarget "Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24863 ; owl:annotatedTarget "iodophenol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003400 ; owl:annotatedTarget "A type of onion bulb formation prominently affecting the area of the basal lamina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003401 ; owl:annotatedTarget "Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003401 ; owl:annotatedTarget "Pins and needles feeling" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003401 ; owl:annotatedTarget "Tingling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003402 ; owl:annotatedTarget "An abnormal reduction in the amplitude of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003403 ; owl:annotatedTarget "A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to a greater than normal decrease in the amplitude during the course of the investigation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003413 ; owl:annotatedTarget "An anomaly of the atlantoaxial joint, i.e., of the joint between the first (atlas) and second (axis) cervical vertebrae." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24864 ; owl:annotatedTarget "iodothyronines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003414 ; owl:annotatedTarget "Partial dislocation of the atlantoaxial joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003416 ; owl:annotatedTarget "An abnormal narrowing of the spinal canal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003416 ; owl:annotatedTarget "Narrow spinal canal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003417 ; owl:annotatedTarget "Frontal schisis (cleft or cleavage) of vertebral bodies." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003418 ; owl:annotatedTarget "Back pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003419 ; owl:annotatedTarget "Lumbago" . [] oboInOwl:hasDbXref , "PMID:23653580", "PMID:23801490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003422 ; owl:annotatedTarget "An abnormality related to a defect of vertebral separation during development." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "salt" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "Salz" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "Salze" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003429 ; owl:annotatedTarget "Reduced amount of myelin in the central nervous system resulting from defective myelinogenesis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003431 ; owl:annotatedTarget "A type of decreased nerve conduction velocity that affects the motor neuron." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003436 ; owl:annotatedTarget "An abnormal prolongation of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003438 ; owl:annotatedTarget "Absence of the Achilles reflex (also known as the ankle jerk reflex), which can normally be elicited by tapping the tendon is tapped while the foot is dorsiflexed." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003438 ; owl:annotatedTarget "Absent ankle reflexes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoid carboxylate anions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "ionic compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003443 ; owl:annotatedTarget "A reduction in the size of nerve terminals." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003444 ; owl:annotatedTarget "Evidence of chronic denervation on electromyography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003445 ; owl:annotatedTarget "The presence of characteristic findings of denervation on electromyography (fibrillations, positive sharp waves, and giant motor unit potentials)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003447 ; owl:annotatedTarget "A reduction in the number of axons in the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003448 ; owl:annotatedTarget "Reduced speed of conduction of the action potential along a sensory nerve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "ionic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003449 ; owl:annotatedTarget "Sudden and involuntary contractions of one or more muscles brought on by exposure to cold temperatures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003450 ; owl:annotatedTarget "The presence of axonal regeneration following a previous axonal lesion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003451 ; owl:annotatedTarget "An increased rate of premature chromosome condensation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "sal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "sales" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003453 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against neutrophils." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003454 ; owl:annotatedTarget "The presence in the serum of autoantibodies directed against thrombocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "salts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003455 ; owl:annotatedTarget "Increased concentration of long-chain fatty acids in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:15961866", "PMID:18751841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003457 ; owl:annotatedTarget "Abnormal results of investigations using electromyography (EMG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003458 ; owl:annotatedTarget "The presence of abnormal electromyographic patterns indicative of myopathy, such as small-short polyphasic motor unit potentials." . [] oboInOwl:hasDbXref "PMID:11508831" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003459 ; owl:annotatedTarget "A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "sel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003460 ; owl:annotatedTarget "Undetectable serum immunoglobulin A level at a value < 5 mg/dL (0.05 g/L)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24866 ; owl:annotatedTarget "sels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003461 ; owl:annotatedTarget "Excretion of peptides conjugated to sialic acid in the urine." . [] oboInOwl:hasDbXref , "PMID:11406682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003463 ; owl:annotatedTarget "Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the extraneuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003467 ; owl:annotatedTarget "Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24867 ; owl:annotatedTarget "monoatomic ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003468 ; owl:annotatedTarget "An abnormality of one or more of the vertebrae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003468 ; owl:annotatedTarget "Multiple vertebral anomalies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24868 ; owl:annotatedTarget "organic salts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003469 ; owl:annotatedTarget "Defective structure and function of myelin sheaths. Dysmyelination is distinguished from demyleination where there is destruction or damage of previously normal myelination." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24868 ; owl:annotatedTarget "organisches Salz" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003470 ; owl:annotatedTarget "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003470 ; owl:annotatedTarget "Inability to move" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003470 ; owl:annotatedTarget "Paralysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003472 ; owl:annotatedTarget "Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003473 ; owl:annotatedTarget "A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003473 ; owl:annotatedTarget "Generalised muscle weakness due to defect at the neuromuscular junction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003474 ; owl:annotatedTarget "An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoid carboxylic acid anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "Ion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003477 ; owl:annotatedTarget "An abnormality characterized by disruption of the normal functioning of peripheral axons." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003481 ; owl:annotatedTarget "A segmental pattern of demyelination and regeneration (remyelination) affecting peripheral nerves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003482 ; owl:annotatedTarget "Electromyographic (EMG) findings characteristic of axonal neuropathy, with normal or slightly decreased nerve conduction velocities, normal or slightly prolonged distal latencies, but significantly reduced motor potentials and sensory amplitudes. There may be spontaneous activity upon needle EMG studies, such as increased insertional activity, positive sharp waves, and fibrillation potentials." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "ion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003484 ; owl:annotatedTarget "Weakness of the muscles of the arms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003484 ; owl:annotatedTarget "Decreased arm strength" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003484 ; owl:annotatedTarget "Weak arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003487 ; owl:annotatedTarget "Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "ion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "Ionen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003491 ; owl:annotatedTarget "An abnormally increased diphosphate(4-) concentration in the urine. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003493 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against nuclei or nuclear components." . [] oboInOwl:hasDbXref "PMID:30524313" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003495 ; owl:annotatedTarget "Cellular accumulation of GM2 gangliosides." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "iones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003496 ; owl:annotatedTarget "An abnormally increased level of immunoglobulin M in blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003498 ; owl:annotatedTarget "A kind of short stature in which different regions of the body are shortened to differing extents." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003498 ; owl:annotatedTarget "Short stature, severe disproportionate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003502 ; owl:annotatedTarget "A mild degree of short stature, more than -2 SD but not more than -3 SD from mean corrected for age and sex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003502 ; owl:annotatedTarget "short stature, mild" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003508 ; owl:annotatedTarget "A kind of short stature in which different regions of the body are shortened to a comparable extent." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24870 ; owl:annotatedTarget "ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "A severe degree of short stature, more than -4 SD from the mean corrected for age and sex." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "Dwarfism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "Proportionate dwarfism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "Severe short stature" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "Short stature, extreme" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003510 ; owl:annotatedTarget "Short stature, severe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003513 ; owl:annotatedTarget "A reduction of the ratio of renal calcium clearance to creatinine clearance to below 0.01." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003513 ; owl:annotatedTarget "Reduced ration of kidney calcium clearance to creatinine clearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003513 ; owl:annotatedTarget "Reduced ration of renal Ca clearance to creatinine clearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003513 ; owl:annotatedTarget "Reduced ration of renal Ca2+ to creatinine clearance" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003517 ; owl:annotatedTarget "Foetal overgrowth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24873 ; owl:annotatedTarget "iron molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003521 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003521 ; owl:annotatedTarget "Disproportionate short-trunked dwarfism" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003521 ; owl:annotatedTarget "Disproportionate short-trunked short stature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003521 ; owl:annotatedTarget "Short-trunked dwarfism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24873 ; owl:annotatedTarget "iron compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003524 ; owl:annotatedTarget "A reduction in methionine synthase activity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003526 ; owl:annotatedTarget "Formation of crystals owing to an increased concentration of orotic acid in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24873 ; owl:annotatedTarget "iron molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003527 ; owl:annotatedTarget "An increased concentration of prostaglandin in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139589 ; owl:annotatedTarget "retinoid carboxylic acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003527 ; owl:annotatedTarget "High urine prostaglandin levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24875 ; owl:annotatedTarget "iron cation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003528 ; owl:annotatedTarget "Elevated calcitonin" . [] oboInOwl:hasDbXref , "PMID:23802516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003529 ; owl:annotatedTarget "An increase in the reabsorption of calcium by the renal tubulus that is not associated with increased parathormone levels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003529 ; owl:annotatedTarget "Parathormone-independent increased renal tubular Ca reabsorption" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003529 ; owl:annotatedTarget "Parathormone-independent increased renal tubular Ca2+ reabsorption" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24875 ; owl:annotatedTarget "Fe cation" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003530 ; owl:annotatedTarget "An increased concentration of glutaric acid in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003530 ; owl:annotatedTarget "Glutarate acidemia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24875 ; owl:annotatedTarget "iron cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003532 ; owl:annotatedTarget "Level of ornithine in the urine above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:17718394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003533 ; owl:annotatedTarget "Decreased level of acetaldehyde dehydrogenase (ALDH). ALDH and alcohol dehydrogenase (ADH) are the primary enzymes involved in alcohol metabolism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003534 ; owl:annotatedTarget "An abnormal reduction in xanthine dehydrogenase level." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003536 ; owl:annotatedTarget "An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003537 ; owl:annotatedTarget "An abnormally low level of uric acid in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003537 ; owl:annotatedTarget "Low blood uric acid levels" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "Beilstein:1721790" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003538 ; owl:annotatedTarget "An increased level of iduronate-2-sulfatase activity in the blood." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "CAS:443-79-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003540 ; owl:annotatedTarget "An impairment in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139590 ; owl:annotatedTarget "primary alpha-hydroxy ketones" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "CAS:443-79-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003541 ; owl:annotatedTarget "Excretion of glycosaminoglycan in the urine. Glycosaminoglycans are long unbranched polysaccharides consisting of a repeating disaccharide unit." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003542 ; owl:annotatedTarget "An increased concentration of pyruvate in the blood." . [] oboInOwl:hasDbXref "PMID:10617757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003546 ; owl:annotatedTarget "A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender." . [] oboInOwl:hasDbXref , "PMID:10617757" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003546 ; owl:annotatedTarget "Decreased ability to exercise" . [] oboInOwl:hasDbXref , "PMID:10617757" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003546 ; owl:annotatedTarget "Inability to exercise" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "Reaxys:1721790" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003547 ; owl:annotatedTarget "The shoulder, or pectoral, girdle is composed of the clavicles and the scapulae. Shoulder-girdle weakness refers to lack of strength of the muscles attaching to these bones, that is, lack of strength of the muscles around the shoulders." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003547 ; owl:annotatedTarget "Weak shoulder muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003548 ; owl:annotatedTarget "An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "isoleucine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003549 ; owl:annotatedTarget "Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003550 ; owl:annotatedTarget "Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003551 ; owl:annotatedTarget "Reduced ability to climb stairs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003551 ; owl:annotatedTarget "Difficulty walking up stairs" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "Hile" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003552 ; owl:annotatedTarget "A condition in which muscles cannot be moved quickly without accompanying pain or spasm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003554 ; owl:annotatedTarget "Atrophy (wasting) affecting primary type 2 muscle fibers. This feature in general can only be observed on muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003554 ; owl:annotatedTarget "Type 2 fibre atrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003554 ; owl:annotatedTarget "Type 2 muscle fibre atrophy" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24898 ; owl:annotatedTarget "rel-(2R,3R)-2-amino-3-methylpentanoic acid" . [] oboInOwl:hasDbXref "PMID:6123177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003555 ; owl:annotatedTarget "Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "An abnormally high degree of muscle fiber size variation. This phenotypic feature can be observed upon muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Increased fibre size variation" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "LIPID_MAPS_class:LMPR01" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Increased variability in muscle fibre diameter" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Increased variability in muscle fibre size" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Increased variation in fibre size" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Increased variation in muscle fibre size" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003557 ; owl:annotatedTarget "Variation in muscle fibre size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003558 ; owl:annotatedTarget "Rhabdomyolysis induced by a viral infection." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "PMID:12769708" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003560 ; owl:annotatedTarget "The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003560 ; owl:annotatedTarget "Muscle biopsy shows dystrophic changes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "PMID:19219049" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003563 ; owl:annotatedTarget "An decreased concentration of low-density lipoprotein cholesterol in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003563 ; owl:annotatedTarget "Decreased LDLc concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003563 ; owl:annotatedTarget "Decreased LDL" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003564 ; owl:annotatedTarget "The presence of a folate sensitive fragile site at chromosome Xq28." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "isoprenoid" . [] oboInOwl:hasDbXref "PMID:10524488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003565 ; owl:annotatedTarget "An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003565 ; owl:annotatedTarget "Elevated ESR" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003565 ; owl:annotatedTarget "High ESR" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139590 ; owl:annotatedTarget "primary alpha-hydroxy-ketone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "isoprenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003566 ; owl:annotatedTarget "An increased concentration of prostaglandin E2 in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24913 ; owl:annotatedTarget "isoprenoids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003568 ; owl:annotatedTarget "A decreased level of glucose-6-phosphate isomerase." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24961 ; owl:annotatedTarget "ketoaldonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003570 ; owl:annotatedTarget "Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase." . [] oboInOwl:hasDbXref "PMID:22593918" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003571 ; owl:annotatedTarget "Increased concentration of proprionic acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24961 ; owl:annotatedTarget "ketoaldonates" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003572 ; owl:annotatedTarget "A decreased concentration of citrulline in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003573 ; owl:annotatedTarget "Increased concentration of total (conjugated and unconjugated) bilirubin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003573 ; owl:annotatedTarget "High bili total" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003574 ; owl:annotatedTarget "A positive response to the regitine blocking test consisting of a substantial reduction in blood pressure following administration of regitine, indicative of the presence of increased levels of epinephrine and norepinephrine in the circulation, which is seen in pheochromocytoma-associated hypertension." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24963 ; owl:annotatedTarget "ketoaldonic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003575 ; owl:annotatedTarget "An abnormally increased sodium concentration in the cytosol." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003577 ; owl:annotatedTarget "A phenotypic abnormality that is present at birth." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24963 ; owl:annotatedTarget "ketoaldonic acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003577 ; owl:annotatedTarget "Symptoms present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003581 ; owl:annotatedTarget "Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003581 ; owl:annotatedTarget "Symptoms begin in adulthood" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24995 ; owl:annotatedTarget "lactam" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003584 ; owl:annotatedTarget "A type of adult onset with onset of symptoms after the age of 60 years." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003587 ; owl:annotatedTarget "Gradual, very slow onset of disease manifestations." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003587 ; owl:annotatedTarget "Gradual onset" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003593 ; owl:annotatedTarget "Onset of signs or symptoms of disease between 28 days to one year of life." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003593 ; owl:annotatedTarget "Infantile onset" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24995 ; owl:annotatedTarget "lactams" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003593 ; owl:annotatedTarget "Onset in first year of life" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003593 ; owl:annotatedTarget "Onset in infancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003596 ; owl:annotatedTarget "A type of adult onset with onset of symptoms at the age of 40 to 60 years." . [] oboInOwl:hasDbXref , "PMID:6960353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003606 ; owl:annotatedTarget "Lack of urothione (the urinary metabolite of molybdenum cofactor) in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24995 ; owl:annotatedTarget "Laktam" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003607 ; owl:annotatedTarget "Increased concentration of 4-hydroxyphenylacetic acid in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24995 ; owl:annotatedTarget "Laktame" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003609 ; owl:annotatedTarget "The presence of foam cells that contain lamellar inclusion bodies." . [] oboInOwl:hasDbXref , "PMID:4195824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003610 ; owl:annotatedTarget "Increased cytoplasmic staining of fibroblasts with toluidine blue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003612 ; owl:annotatedTarget "If positive, the ferric chloride test indicates an increased concentration of phenols in the urine or blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003612 ; owl:annotatedTarget "Positive FeCl3 test" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003613 ; owl:annotatedTarget "The presence of circulating autoantibodies to phospholipids." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139590 ; owl:annotatedTarget "primary alpha-hydroxy-ketones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24995 ; owl:annotatedTarget "lactams" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003614 ; owl:annotatedTarget "Increased concentration of trimethylamine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003614 ; owl:annotatedTarget "High urine trimethylamine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003621 ; owl:annotatedTarget "Onset of signs or symptoms of disease between the age of 5 and 15 years." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003621 ; owl:annotatedTarget "Signs and symptoms begin before 15 years of age" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003623 ; owl:annotatedTarget "Onset of signs or symptoms of disease within the first 28 days of life." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003623 ; owl:annotatedTarget "Neonatal onset" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003634 ; owl:annotatedTarget "Congenital lack of development of the muscles, which are then replaced by a mixture of dense fat and fibrous tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003634 ; owl:annotatedTarget "Absent muscles since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003635 ; owl:annotatedTarget "Loss (disappearance) of previously present subcutaneous fat tissue in arm or leg." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003635 ; owl:annotatedTarget "Loss of fat tissue below the skin in limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003637 ; owl:annotatedTarget "An abnormal reduction in 4-hydroxyphenylpyruvate dioxygenase level." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003637 ; owl:annotatedTarget "Reducted HPPD activity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003639 ; owl:annotatedTarget "The concentration of epinephrine in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "Beilstein:3587719" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "CAS:113-21-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003641 ; owl:annotatedTarget "The presence of free hemoglobin in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003641 ; owl:annotatedTarget "Haemoglobin in urine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003641 ; owl:annotatedTarget "Hemoglobin in urine" . [] oboInOwl:hasDbXref , "PMID:15105360", "PMID:22516080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003642 ; owl:annotatedTarget "Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "CAS:113-21-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003643 ; owl:annotatedTarget "Abnormally reduced sulfite oxidase level." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003645 ; owl:annotatedTarget "Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003645 ; owl:annotatedTarget "Prolonged PTT" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "Gmelin:240074" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003646 ; owl:annotatedTarget "Abnormally increased concentration of hydrogencarbonate in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139590 ; owl:annotatedTarget "primary alpha-hydroxyketone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "2-hydroxypropanoate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003646 ; owl:annotatedTarget "Increased urine bicarbonate concentration" . [] oboInOwl:hasDbXref "PMID:2989828" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003647 ; owl:annotatedTarget "A deficiency of the electron transfer flavoprotein-ubiquinone oxidoreductase." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "lactate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003648 ; owl:annotatedTarget "An increased concentration of lactic acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003648 ; owl:annotatedTarget "High urine lactic acid levels" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "2-hydroxypropanoic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003649 ; owl:annotatedTarget "Abnormality of glycoside metabolism." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "2-hydroxypropionate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003651 ; owl:annotatedTarget "The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003652 ; owl:annotatedTarget "Recurring episodes of myoglobinuria, i.e., of the presence of myoglobin in the urine. This is usually a consequence of rhabdomyolysis, i.e., of the destruction of muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003652 ; owl:annotatedTarget "Myoglobinuria, recurrent" . [] oboInOwl:hasDbXref , "PMID:4195824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003653 ; owl:annotatedTarget "Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "MeCH(OH)CO2 anion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003654 ; owl:annotatedTarget "An abnormal reduction in dihydropyrimidine dehydrogenase (NADP+) level." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003655 ; owl:annotatedTarget "An abnormality of glycoprotein metabolism related to a decreased level of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "b-lactate" . [] oboInOwl:hasDbXref "PMID:17183453", "PMID:31667734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003657 ; owl:annotatedTarget "Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide. Deposition of granular osmiophilic material (GOM) is the vascular pathological hallmark of CADASIL, which is the most prevalent hereditary small vessel disease and is caused by missense mutations in the NOTCH3 gene. GOM have been shown to contain NOTCH3 ectodomain (NOTCH3ECD) and extracellular matrix proteins, and can be visualized ultrastructurally in the tunica media of small arteries and capillaries. These electron dense GOM deposits are located in the basement membrane of mural cells, i.e. vascular smooth muscle cells and pericytes. In both manifest and pre-manifest CADASIL patients, GOM deposits are present not only in brain vessels, but also in vessels of other organs, such as the skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_24996 ; owl:annotatedTarget "beta-lactate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003658 ; owl:annotatedTarget "A decreased concentration of methionine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003658 ; owl:annotatedTarget "Decreased plasma methionine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003658 ; owl:annotatedTarget "Decreased serum methionine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003665 ; owl:annotatedTarget "Muscular atrophy affecting the muscles of the pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003674 ; owl:annotatedTarget "The age group in which disease manifestations appear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003674 ; owl:annotatedTarget "Age symptoms begin" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003676 ; owl:annotatedTarget "Worsens with time" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003677 ; owl:annotatedTarget "Signs and symptoms worsen slowly with time" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003678 ; owl:annotatedTarget "Worsening quickly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003678 ; owl:annotatedTarget "Rapidly progressive disorder" . [] oboInOwl:hasDbXref hp:layperson, ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003680 ; owl:annotatedTarget "Does not worsen" . [] oboInOwl:hasDbXref , "PMID:20181480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003687 ; owl:annotatedTarget "An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003687 ; owl:annotatedTarget "Centralised nuclei" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003687 ; owl:annotatedTarget "Centralised sarcomeric nuclei" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003687 ; owl:annotatedTarget "Centrally nucleated skeletal muscle fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003688 ; owl:annotatedTarget "An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003688 ; owl:annotatedTarget "Cytochrome C oxidase-negative muscle fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003689 ; owl:annotatedTarget "The presence of multiple deletions of mitochondrial DNA (mtDNA)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003690 ; owl:annotatedTarget "Reduced strength and weakness of the muscles of the arms and legs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003690 ; owl:annotatedTarget "Limb muscle weakness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003690 ; owl:annotatedTarget "Limb weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003691 ; owl:annotatedTarget "Abnormal protrusion of the scapula away from the surface of the back." . [] a owl:Axiom ; rdfs:label "Winged scapula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0003691 ; owl:annotatedTarget "MEDDRA:10067628" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003691 ; owl:annotatedTarget "Winged shoulder blade" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139590 ; owl:annotatedTarget "primary alpha-hydroxyketones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003693 ; owl:annotatedTarget "Muscular atrophy affecting muscles in the distal portions of the extremities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003693 ; owl:annotatedTarget "Distal muscle degeneration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003693 ; owl:annotatedTarget "Distal muscle wasting" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003694 ; owl:annotatedTarget "Lack of strength of the proximal musculature occurring late in the clinical course." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Beilstein:636005" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003696 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003696 ; owl:annotatedTarget "Absent end part of the outermost bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003696 ; owl:annotatedTarget "Absent end part of the outermost bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003696 ; owl:annotatedTarget "Absent end part of the outermost bone of the pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003697 ; owl:annotatedTarget "Muscular atrophy in the distribution of shoulder girdle and peroneal muscles." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "CAS:328-39-2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003698 ; owl:annotatedTarget "Difficulty in standing" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "CAS:328-39-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Diffuse skeletal muscle wasting" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Generalised amyotrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Generalised muscle atrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Generalised muscle degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Generalized muscle degeneration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Muscle atrophy, generalised" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Muscle atrophy, generalized" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003700 ; owl:annotatedTarget "Muscular atrophy, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003701 ; owl:annotatedTarget "A lack of strength of the proximal muscles." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Gmelin:50203" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003701 ; owl:annotatedTarget "Weakness in muscles of upper arms and upper legs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003701 ; owl:annotatedTarget "Proximal neurogenic muscle weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003707 ; owl:annotatedTarget "Enlargement of the muscles of the calf due to their replacement by connective tissue or fat." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Sudden and involuntary contractions of one or more muscles brought on by physical exertion." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Exercise-induced muscle cramping" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Exercise-induced muscle cramps" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Muscle cramps following exercise" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Muscle cramps on exercise" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Muscle cramps on exertion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003710 ; owl:annotatedTarget "Muscle cramps with exertion" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01100048" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003712 ; owl:annotatedTarget "Abnormal increase in muscle size and mass not due to training." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003712 ; owl:annotatedTarget "Increased skeletal muscle cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003713 ; owl:annotatedTarget "Abnormal cell death involving muscle fibers usually associated with break in, or absence of, muscle surface fiber membrane and resulting in irreversible damage to muscle fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003713 ; owl:annotatedTarget "Muscle fibre necrosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003715 ; owl:annotatedTarget "Myofibrillar structural changes characterized by abnormal intracellular accumulation of the intermediate filament desmin and other proteins." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003716 ; owl:annotatedTarget "Generalised muscular appearance from birth" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Reaxys:636005" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003717 ; owl:annotatedTarget "Minimal fat below the skin" . [] oboInOwl:hasDbXref "PMID:20300641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003719 ; owl:annotatedTarget "Percussion-induced, local prolonged contractions (mounding) in muscle persisting for several seconds." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "leucine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003720 ; owl:annotatedTarget "Hypertrophy (increase in size) of muscle tissue in a generalized (not localized) distribution." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003720 ; owl:annotatedTarget "Generalised increase in muscle cell size" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003720 ; owl:annotatedTarget "Generalised muscle hypertrophy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003720 ; owl:annotatedTarget "Generalized increase in muscle cell size" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "(+-)-Leucine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003722 ; owl:annotatedTarget "Weakness of the muscles involved in neck flexion (sternocleidomastoid, longus capitus, longus colli, and scalenus anterior)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003722 ; owl:annotatedTarget "Neck flexion weakness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139592 ; owl:annotatedTarget "tertiary alpha-hydroxy ketones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "(RS)-Leucine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003724 ; owl:annotatedTarget "Amyotrophy affecting the muscles of the shoulder girdle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003724 ; owl:annotatedTarget "Shoulder girdle muscle wasting" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003724 ; owl:annotatedTarget "Shoulder-girdle muscle atrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003730 ; owl:annotatedTarget "Spontaneous, repetitive electrical activity demonstrated by electromyography (EMG)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "2-amino-4-methylpentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003731 ; owl:annotatedTarget "Weakness of the quadriceps muscle (that is, of the muscle fasciculus of quadriceps femoris)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003731 ; owl:annotatedTarget "Quadriceps weakness" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "DL-Leucine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003733 ; owl:annotatedTarget "Muscle hypertrophy affecting the thighs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003733 ; owl:annotatedTarget "Increased thigh size" . [] oboInOwl:hasDbXref , "PMID:17027858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003736 ; owl:annotatedTarget "The lysosomal-vacuolar pathway has a role in the controlled intracellular digestion of macromolecules such as protein complexes and organelles. This feature refers to the presence of an abnormally increased number of autophagic vacuoles in muscle tissue." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Hleu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003737 ; owl:annotatedTarget "A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003738 ; owl:annotatedTarget "The occurrence of an unusually high amount of muscle pain following exercise." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003738 ; owl:annotatedTarget "Exercise-induced muscle pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003738 ; owl:annotatedTarget "Muscle pain on exercise" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003738 ; owl:annotatedTarget "Muscle pain with exercise" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "L" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003738 ; owl:annotatedTarget "Muscle pain, exercise-induced" . [] oboInOwl:hasDbXref , "PMID:7678441" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003740 ; owl:annotatedTarget "Myotonia that occurs after a period of rest and decreases with continuing exercise." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003743 ; owl:annotatedTarget "A type of autosomal dominant inheritance involving a gene that exhibits anticipation, the increase in severity and/or an earlier age of onset in subsequent generations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003744 ; owl:annotatedTarget "A type of genetic anticipation observed predominantly upon transmission from affected males." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003745 ; owl:annotatedTarget "Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003745 ; owl:annotatedTarget "No previous family history" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Leu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003749 ; owl:annotatedTarget "Weakness of the muscles of the pelvic girdle (also known as the hip girdle), that is, lack of strength of the muscles around the pelvis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Leucin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003750 ; owl:annotatedTarget "An abnormal, increased fatiguability of the musculature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003752 ; owl:annotatedTarget "Recurrent episodes of muscle flaccidity, a type of paralysis in which a muscle becomes soft and yields to passive stretching." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003755 ; owl:annotatedTarget "The presence of abnormal muscle fiber size such that type 1 fibers are smaller than type 2 fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003755 ; owl:annotatedTarget "Type 1 fibres relatively smaller than type 2 fibres" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25017 ; owl:annotatedTarget "Leuzin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003758 ; owl:annotatedTarget "Reduced fat tissue below the skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003759 ; owl:annotatedTarget "Congenital underdevelopment of lymph vessels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003759 ; owl:annotatedTarget "Underdeveloped lymphatic vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003760 ; owl:annotatedTarget "Mechanical percussion (i.e., striking a muscle with a reflex hammer) leads to spreading waves of muscle contractions that begin proximally and spread laterally across the muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003761 ; owl:annotatedTarget "Formation of calcium deposits in any soft tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003761 ; owl:annotatedTarget "Calcium buildup in soft tissues of body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003762 ; owl:annotatedTarget "A malformation of the uterus in which the uterus is present as a paired organ as a result of the failure of fusion of the mullerian ducts during embryogenesis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003762 ; owl:annotatedTarget "Double uterus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139592 ; owl:annotatedTarget "tertiary alpha-hydroxy-ketone" . [] oboInOwl:hasDbXref "PMID:29926505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003763 ; owl:annotatedTarget "Bruxism is characterized by the grinding of the teeth including the clenching of the jaw and typically occur during sleep, but also can occur while the affected individual is awake." . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003763 ; owl:annotatedTarget "Teeth grinding" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003764 ; owl:annotatedTarget "A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003764 ; owl:annotatedTarget "Mole" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003765 ; owl:annotatedTarget "A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003768 ; owl:annotatedTarget "Episodes of muscle weakness." . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "Pulp calcifications may appear as punctate calcifications, irregular, roughly spherical mineralized masses in any part of the pulp. It may occur isolated or associated to calcifications elsewhere such as the carotid arteries and kidneys. The diagnosis pulp calcifications can be established using radiological studies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "Pulp calcifications" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "Pulp denticles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "Pulp stones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "False denticles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "False pulp stones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "True denticles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0003771 ; owl:annotatedTarget "True pulp stones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003774 ; owl:annotatedTarget "A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003774 ; owl:annotatedTarget "End-stage renal failure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003774 ; owl:annotatedTarget "Stage 5 chronic kidney disease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003774 ; owl:annotatedTarget "Renal failure, endstage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003777 ; owl:annotatedTarget "Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003777 ; owl:annotatedTarget "Flattened and twisted hair" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "Beilstein:1616991" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003778 ; owl:annotatedTarget "Decreased size of mandibular ramus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0003778 ; owl:annotatedTarget "Decreased height of mandibular ramus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003779 ; owl:annotatedTarget "Deep antegonial notch of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003779 ; owl:annotatedTarget "Large antegonial notch of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003781 ; owl:annotatedTarget "Excessive production of saliva." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "CAS:70-54-2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003781 ; owl:annotatedTarget "Excessive salivation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003781 ; owl:annotatedTarget "Mouth watering" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003781 ; owl:annotatedTarget "Oversalivation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003781 ; owl:annotatedTarget "Watery mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003782 ; owl:annotatedTarget "A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming", "PMID:12615172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003785 ; owl:annotatedTarget "Decreased concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003787 ; owl:annotatedTarget "Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in type 1 and type 2 muscle fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003787 ; owl:annotatedTarget "Type 1 and type 2 muscle fibre minicore regions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003789 ; owl:annotatedTarget "Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in muscle fibers." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "CAS:70-54-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003795 ; owl:annotatedTarget "Developmental hypoplasia (shortening) of middle phalanx of toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003795 ; owl:annotatedTarget "Short middle bones (feet)" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "Gmelin:279284" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003796 ; owl:annotatedTarget "Irregularity of the iliac crest, which is the superior border of the wing of the ilium." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003797 ; owl:annotatedTarget "Muscular atrophy affecting the muscles of the limb girdle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003797 ; owl:annotatedTarget "Wasting of limb-girdle muscle" . [] oboInOwl:hasDbXref , "PMID:11333380" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003798 ; owl:annotatedTarget "Nemaline rods are abnormal bodies that can occur in skeletal muscle fibers. The rods can be observed on histological analysis of muscle biopsy tissue or upon electron microscopy, where they appear either as extensions of sarcomeric Z-lines, in random array without obvious attachment to Z-lines (often in areas devoid of sarcomeres) or in large clusters localized at the sarcolemma or intermyofibrillar spaces." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003799 ; owl:annotatedTarget "Marked delay in bone age" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003799 ; owl:annotatedTarget "Markedly retarded bone age" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003803 ; owl:annotatedTarget "An abnormal predominance of type I muscle fibers (in general, this feature can only be observed on muscle biopsy)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003803 ; owl:annotatedTarget "Type 1 muscle fibre predominance" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003803 ; owl:annotatedTarget "Type I muscle fibre predominance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003805 ; owl:annotatedTarget "Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003808 ; owl:annotatedTarget "Abnormal muscle tone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "Reaxys:1616991" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003811 ; owl:annotatedTarget "Death within the first 28 days of life." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003811 ; owl:annotatedTarget "Neonatal lethal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003812 ; owl:annotatedTarget "A variability of phenotypic features." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003812 ; owl:annotatedTarget "Clinical heterogeneity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003819 ; owl:annotatedTarget "Death in during childhood, defined here as between the ages of 2 and 10 years." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003819 ; owl:annotatedTarget "Death in childhood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Death of the fetus in utero after at least 22 weeks of gestation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Late foetal death" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Stillbirth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Stillborn" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139592 ; owl:annotatedTarget "tertiary alpha-hydroxy-ketones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "2,6-diaminohexanoic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Fetal death" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Foetal death" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003826 ; owl:annotatedTarget "Foetal demise" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003828 ; owl:annotatedTarget "A variable severity of phenotypic features." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003828 ; owl:annotatedTarget "Highly variable severity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003829 ; owl:annotatedTarget "Description of conditions in which not all individuals with a given genotype exhibit the disease. Penetrance is the proportion that develop disease given a lifespan of 80 years." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003831 ; owl:annotatedTarget "Description of conditions in which age of onset is typically later in life and in which penetrance is dependent on the age of the subject." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "lysine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "K" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003834 ; owl:annotatedTarget "A displacement or misalignment of the humerus with respect to the other bones of the should joint. Note that a subluxation is a partial dislocation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003834 ; owl:annotatedTarget "Shoulder dislocation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "LYS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003835 ; owl:annotatedTarget "A partial dislocation of the shoulder joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003835 ; owl:annotatedTarget "Partial shoulder dislocation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "Lysin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003837 ; owl:annotatedTarget "Formation of calcified tissue in the soft tissues surrounding the shoulder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003837 ; owl:annotatedTarget "Calcification of the soft-tissue around the shoulders" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25094 ; owl:annotatedTarget "alpha,epsilon-diaminocaproic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003839 ; owl:annotatedTarget "Abnormal shape of end part of upper limb long bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003840 ; owl:annotatedTarget "A delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003840 ; owl:annotatedTarget "Delayed maturation fo the end part of the upper limb bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003841 ; owl:annotatedTarget "Fragmented end part of upper limb bones" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "CAS:7439-95-4" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "Gmelin:16207" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003842 ; owl:annotatedTarget "Irregular end part of upper limb bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "magnesium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003843 ; owl:annotatedTarget "Round end part of upper limb bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139592 ; owl:annotatedTarget "tertiary alpha-hydroxyketone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "12Mg" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003844 ; owl:annotatedTarget "Small end part of upper limb bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "Magnesium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003846 ; owl:annotatedTarget "Broad growth plates of upper limbs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003848 ; owl:annotatedTarget "Cupped wide portion of the upper limb bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "Mg" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003849 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003849 ; owl:annotatedTarget "Flared wide portion of the upper limb bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "Mg" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003850 ; owl:annotatedTarget "Irregular wide portion of upper limb bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003854 ; owl:annotatedTarget "Increased bone density in wide portion of the upper limb bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "magnesio" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003855 ; owl:annotatedTarget "Spurred wide portion of upper limb bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25107 ; owl:annotatedTarget "magnesium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003856 ; owl:annotatedTarget "Increased width (breadth) of metaphyses of the arms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003856 ; owl:annotatedTarget "Broad wide portion of upper limb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003860 ; owl:annotatedTarget "An elevation in bone density in one or more diaphyses of the arms. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003860 ; owl:annotatedTarget "Increased bone density in central part of long bone of upper limbs" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "Beilstein:3905858" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003861 ; owl:annotatedTarget "Broad shaft of long bone of the upper limbs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003861 ; owl:annotatedTarget "Wide shaft of long bone of the upper limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003862 ; owl:annotatedTarget "Missing humerus bone associated with congenital failure of development." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003862 ; owl:annotatedTarget "Absent long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003863 ; owl:annotatedTarget "Angulated long bone in upper arm" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "Beilstein:4135334" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003864 ; owl:annotatedTarget "Clefting affecting the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003864 ; owl:annotatedTarget "Notched long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_139592 ; owl:annotatedTarget "tertiary alpha-hydroxyketones" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "CAS:769-61-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003865 ; owl:annotatedTarget "A bending or abnormal curvature of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003865 ; owl:annotatedTarget "Bowed long bone in upper arm" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "Gmelin:328159" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003870 ; owl:annotatedTarget "Crumpled long bone in upper arm" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "hydroxy(phenyl)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003871 ; owl:annotatedTarget "Deformed long bone in upper arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003872 ; owl:annotatedTarget "Presence of more than one exostosis originating in one or noth humerus bones. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "mandelate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003879 ; owl:annotatedTarget "False joint (long bone in upper arm)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "2-hydroxy-2-(4-hydroxyphenyl)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003881 ; owl:annotatedTarget "Increased bone density in long bone of upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "alpha-hydroxybenzeneacetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003882 ; owl:annotatedTarget "Reduction in diameter of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003882 ; owl:annotatedTarget "Slender long bone of upper arm" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "alpha-hydroxybenzeneacetic acid, ion(1-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003883 ; owl:annotatedTarget "Tapered long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003884 ; owl:annotatedTarget "Triangular long bone of upper arm" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25147 ; owl:annotatedTarget "mandelate ion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003886 ; owl:annotatedTarget "Wide long bone of upper arm" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25212 ; owl:annotatedTarget "metabolite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003887 ; owl:annotatedTarget "Abnormal head of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25212 ; owl:annotatedTarget "metabolites" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003888 ; owl:annotatedTarget "Flattended head of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_140325 ; owl:annotatedTarget "secondary carboxamides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25212 ; owl:annotatedTarget "primary metabolites" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25212 ; owl:annotatedTarget "secondary metabolites" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003891 ; owl:annotatedTarget "An anomaly of the humeral epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003891 ; owl:annotatedTarget "Abnormality of end part of the long bone of the upper arm" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25213 ; owl:annotatedTarget "a metal cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003892 ; owl:annotatedTarget "Lack of formation of bone in the epiphysis of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003892 ; owl:annotatedTarget "Absent maturation of end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25213 ; owl:annotatedTarget "metal cations" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25216 ; owl:annotatedTarget "metalloporphyrins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003893 ; owl:annotatedTarget "Ossification of the humeral epiphysis at an earlier age than normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003893 ; owl:annotatedTarget "Accelerated maturation of end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25216 ; owl:annotatedTarget "metaloporphyrins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003894 ; owl:annotatedTarget "A delay in the process of formation and maturation of the humeral epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003894 ; owl:annotatedTarget "Delayed maturation of the end part of the long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25235 ; owl:annotatedTarget "monomethoxybenzenes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003895 ; owl:annotatedTarget "Flattened end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25274 ; owl:annotatedTarget "methylated amines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003896 ; owl:annotatedTarget "Irregular end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25345 ; owl:annotatedTarget "methyltetrahydrofolates" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003897 ; owl:annotatedTarget "Irregular maturation of the end part of the long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25354 ; owl:annotatedTarget "mineralocorticoids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003898 ; owl:annotatedTarget "Large end part of long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003899 ; owl:annotatedTarget "Round end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25355 ; owl:annotatedTarget "mitochondrial electron transport chain inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003900 ; owl:annotatedTarget "Small end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25355 ; owl:annotatedTarget "mitochondrial electron-transport chain inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25355 ; owl:annotatedTarget "mitochondrial respiratory chain inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003902 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the humeral epiphysis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25362 ; owl:annotatedTarget "homoatomic molecule" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003903 ; owl:annotatedTarget "Increased width of the humeral epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003903 ; owl:annotatedTarget "Wide end part of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25362 ; owl:annotatedTarget "homoatomic molecules" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003904 ; owl:annotatedTarget "Wide end part of upper limb bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25367 ; owl:annotatedTarget "molecule" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003905 ; owl:annotatedTarget "Abnormality of arm long bone growth plate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25367 ; owl:annotatedTarget "Molekuel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003906 ; owl:annotatedTarget "Increased width of the humeral epiphyseal growth plate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0003906 ; owl:annotatedTarget "Wide long bone of arm growth plate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25367 ; owl:annotatedTarget "molecula" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003907 ; owl:annotatedTarget "Abnormality of the wide portion of the long bone in upper arm" . [] oboInOwl:hasDbXref "PMID:15206413", "PMID:20544318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003908 ; owl:annotatedTarget "Fracture or fragmentation at the lateral portion of the metaphysis of a long bone. The radiographic appearance is that of a small corner of metaphysis separated from the metaphyseal edge by thin linear radiolucency. This feature can be observed in child abuse but fragmented appearance of the metaphysis or facture-like lesions can also be detected in the setting of certain skeletal dysplasias." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25367 ; owl:annotatedTarget "molecules" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003910 ; owl:annotatedTarget "Enlarged wide portion of long bone of upper arm" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25367 ; owl:annotatedTarget "neutral molecular compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003911 ; owl:annotatedTarget "Flaring (increase of width with a splayed appearance) of the humeral metaphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003911 ; owl:annotatedTarget "Flared wide portion of long bone of upper arm" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_140785 ; owl:annotatedTarget "MetaCyc:CPD-20938" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003913 ; owl:annotatedTarget "Irregular wide portion of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25375 ; owl:annotatedTarget "monamines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003914 ; owl:annotatedTarget "Irregular bone maturation of the wide portion of the long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25375 ; owl:annotatedTarget "monoamines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003917 ; owl:annotatedTarget "Pointed wide portion of long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003918 ; owl:annotatedTarget "Hardening of wide portion of long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003918 ; owl:annotatedTarget "Stiffening of wide portion of long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003920 ; owl:annotatedTarget "Sloping metaphysis of long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003921 ; owl:annotatedTarget "Laterally sloping metaphysis of long bone of upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003922 ; owl:annotatedTarget "Spurred metaphysis of long bone of upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25384 ; owl:annotatedTarget "monocarboxylic acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003923 ; owl:annotatedTarget "Square metaphysis of long bone of upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25414 ; owl:annotatedTarget "monoatomic monocations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003924 ; owl:annotatedTarget "Speckled calcification in metaphysis of long bone of upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25414 ; owl:annotatedTarget "monovalent inorganic cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003926 ; owl:annotatedTarget "An anomaly of the humeral diaphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003926 ; owl:annotatedTarget "Abnormality of shaft of long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25481 ; owl:annotatedTarget "naphthoquinones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003927 ; owl:annotatedTarget "An abnormal irregularity of the cortical surface of the diaphysis (shaft) of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003933 ; owl:annotatedTarget "Increased bone density in shaft of long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003934 ; owl:annotatedTarget "Slender shaft of long bone in upper arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003935 ; owl:annotatedTarget "Increased width of the humeral diaphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003935 ; owl:annotatedTarget "Broad shaft of long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003935 ; owl:annotatedTarget "Wide shaft of long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003938 ; owl:annotatedTarget "Bone fusion involving the elbow" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_140785 ; owl:annotatedTarget "an R-cob(III)alamin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25512 ; owl:annotatedTarget "neurotransmitters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003939 ; owl:annotatedTarget "An abnormal osseous union (fusion) between the ulna and the humerus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25513 ; owl:annotatedTarget "neutral glycosphingolipids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003943 ; owl:annotatedTarget "Abnormality of the joint spaces of the elbow" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "nitrogen" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003944 ; owl:annotatedTarget "Narrow joint spaces of the elbow" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "7N" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003946 ; owl:annotatedTarget "Abnormality of end part of the elbow bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "N" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003947 ; owl:annotatedTarget "A delay in the process of formation and maturation of the epiphysis of one or more long bones that are part of the elbow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003947 ; owl:annotatedTarget "Delayed maturation of the end part of the elbow bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "Stickstoff" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003948 ; owl:annotatedTarget "Irregular end part of the elbow bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "azote" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003949 ; owl:annotatedTarget "Abnormal wide portion of elbow bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003950 ; owl:annotatedTarget "Flared wide portion of elbow bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003951 ; owl:annotatedTarget "Irregularity of the normally smooth surface of the metaphysis at the distal end of the humerus (at the elbow)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "nitrogen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003951 ; owl:annotatedTarget "Irregular wide portion of elbow bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003953 ; owl:annotatedTarget "Absence of one or more forearm bones associated with congenital failure of development." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003953 ; owl:annotatedTarget "Absent forearm bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25555 ; owl:annotatedTarget "nitrogeno" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003954 ; owl:annotatedTarget "Angulated forearm bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003955 ; owl:annotatedTarget "A descriptive term for a forearm bone that appears to have an additional bone within it on radiography." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003955 ; owl:annotatedTarget "Bone-in-a-bone appearance of forearm" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "nonmetal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003956 ; owl:annotatedTarget "A bending or abnormal curvature affecting either the radius, the ulna, or both." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003956 ; owl:annotatedTarget "Bowed forearm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "Nichtmetall" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003959 ; owl:annotatedTarget "Deformed forearm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "Nichtmetalle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003961 ; owl:annotatedTarget "Fractured forearm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "no metal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "no metales" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003967 ; owl:annotatedTarget "Increased bone density of forearm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "non-metal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "non-metaux" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003971 ; owl:annotatedTarget "Abnormally wide bone of the skeleton of forearm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003971 ; owl:annotatedTarget "Broad forearm bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003971 ; owl:annotatedTarget "Wide forearm bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "nonmetal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003974 ; owl:annotatedTarget "Missing radius bone associated with congenital failure of development." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003974 ; owl:annotatedTarget "Missing outer large bone of forearm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25585 ; owl:annotatedTarget "nonmetals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003981 ; owl:annotatedTarget "Increased width of the radius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003982 ; owl:annotatedTarget "Missing ulna bone associated with congenital failure of development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0003982 ; owl:annotatedTarget "Absent ulnae" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "Beilstein:3590530" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003988 ; owl:annotatedTarget "Increased length of the ulna." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "CAS:646-29-7" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "Gmelin:344065" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "PMID:16401590" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003991 ; owl:annotatedTarget "Osteosclerosis (increased density related to increased bone mass) of the ulna." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "PMID:19184617" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003992 ; owl:annotatedTarget "Reduction in diameter of the ulna." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "PMID:3180776" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003993 ; owl:annotatedTarget "Increased width of the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0003994 ; owl:annotatedTarget "An injury of the wrist with displacement of any of the eight carpal bones." . [] a owl:Axiom ; rdfs:label "Dislocation of wrist" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0003994 ; owl:annotatedTarget "MEDDRA:10013184" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "PMID:7452460" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003994 ; owl:annotatedTarget "Dislocated wrist" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0003994 ; owl:annotatedTarget "Dislocations of the wrists" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_142533 ; owl:annotatedTarget "PMID:7691279" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "Reaxys:3590530" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "octadecanoate" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "octadecanoate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "CH3-[CH2]16-COO(-)" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "Stearate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "octadecanoic acid, ion(1-)" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "stearate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25629 ; owl:annotatedTarget "stearic acid, ion(1-)" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25676 ; owl:annotatedTarget "oligopeptides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25676 ; owl:annotatedTarget "Oligopeptid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004012 ; owl:annotatedTarget "A premature fusion of the epiphyseal plates of the radius. Epiphyseal plates are located at the distal and proximal ends of the long bones, in this case of the radius and premature fusion will have an effect on the growh of the radial bone, inhibiting or at least disturbing the normal growth and development of the bone." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_142533 ; owl:annotatedTarget "->4)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosylp-(1->4)-beta-D-glucopyranosyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25676 ; owl:annotatedTarget "oligopeptido" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004014 ; owl:annotatedTarget "Abnormal increase in width of the epiphyseal growth plate of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25693 ; owl:annotatedTarget "organic heteromonocyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004018 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25696 ; owl:annotatedTarget "organic anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004019 ; owl:annotatedTarget "Irregularity of the normally smooth surface of the metaphysis of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25697 ; owl:annotatedTarget "organic cations" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25698 ; owl:annotatedTarget "ether" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004026 ; owl:annotatedTarget "Increase in width (breadth) of the radial metaphysis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25698 ; owl:annotatedTarget "ethers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004027 ; owl:annotatedTarget "An anomaly of the radial diaphysis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25698 ; owl:annotatedTarget "ethers" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25699 ; owl:annotatedTarget "organic ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004031 ; owl:annotatedTarget "Increase in width of the diaphysis of radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25701 ; owl:annotatedTarget "organic oxides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organic phosphate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142533 ; owl:annotatedTarget "->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organic phosphate ester" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organic phosphate esters" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organic phosphates" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organophosphate ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004042 ; owl:annotatedTarget "Irregularity of the normally smooth surface of the metaphysis of the ulna." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25703 ; owl:annotatedTarget "organophosphate esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004045 ; owl:annotatedTarget "A sloped configuration of the metaphysis (shaft) of the ulna." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25704 ; owl:annotatedTarget "organic sulfates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004047 ; owl:annotatedTarget "Increase in width (breadth) of the ulnar metaphysis." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_2571 ; owl:annotatedTarget "Aliphatic alcohol" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004050 ; owl:annotatedTarget "The total absence of the hand, with no bony elements distal to the radius or ulna." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004050 ; owl:annotatedTarget "Absent hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_2571 ; owl:annotatedTarget "aliphatic alcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004051 ; owl:annotatedTarget "Ossification of hand bones at an earlier age than normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004051 ; owl:annotatedTarget "Accelerated maturation of hand bones" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_2571 ; owl:annotatedTarget "an aliphatic alcohol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142533 ; owl:annotatedTarget "->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl group" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25710 ; owl:annotatedTarget "organophosphorus compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004052 ; owl:annotatedTarget "Ossification of hand bones is less advanced than would be expected according to age-adjusted norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004052 ; owl:annotatedTarget "Delayed maturation of the hand bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25710 ; owl:annotatedTarget "organophosphorus compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004053 ; owl:annotatedTarget "Pattern of hand-wrist development does not fit the normal sequence of ossification of the individual bones of the hand." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25728 ; owl:annotatedTarget "osmolytes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004054 ; owl:annotatedTarget "Osteosclerosis affecting one or more bones of the hand." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004054 ; owl:annotatedTarget "Generalised sclerosis of hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004054 ; owl:annotatedTarget "Increased bone density in hand bone" . [] oboInOwl:hasDbXref , "PMID:20301304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004057 ; owl:annotatedTarget "Fusion of the hands and feet by a thin membrane of skin (scarring) seen in forms of dystrophic epidermolysis bullosa and leading to a \"mitten\" hand deformity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25741 ; owl:annotatedTarget "oxide" . [] oboInOwl:hasDbXref , "PMID:28603568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004059 ; owl:annotatedTarget "Wrist is bent inward toward the thumb because of a congenital defect associated with shortening or absence of the radius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004060 ; owl:annotatedTarget "A hand in which the fingers are of nearly equal length and deflected at the first interphalangeal joint, so as to give a forklike shape consisting of separation of the first and second as well as the third and fourth digits." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004095 ; owl:annotatedTarget "Curved fingers" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25741 ; owl:annotatedTarget "oxides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004097 ; owl:annotatedTarget "Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004097 ; owl:annotatedTarget "Atypical position of finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004097 ; owl:annotatedTarget "Finger pointing in a different direction than usual" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004099 ; owl:annotatedTarget "Significant increase in the length and girth of most or all of a digit compared to its contralateral digit (if unaffected) or compared to what would be expected for age/body build. The increased girth is accompanied by an increase in the dorso-ventral dimension AND the lateral dimension of the digit." . [] a owl:Axiom ; rdfs:label "Macrodactyly" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0004099 ; owl:annotatedTarget "MEDDRA:10025386" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004099 ; owl:annotatedTarget "Finger overgrowth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25754 ; owl:annotatedTarget "oxo carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004100 ; owl:annotatedTarget "An anomaly of the second finger, also known as the index finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004100 ; owl:annotatedTarget "Abnormality of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004112 ; owl:annotatedTarget "An abnormal groove on the midline of the nose that may extend to the nasal tip." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25754 ; owl:annotatedTarget "oxo acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004112 ; owl:annotatedTarget "Central nasal groove" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004112 ; owl:annotatedTarget "Midline nasal groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "This term groups together three conditions that presumably represent different degrees of severity of a midline defect of the nose or nasal tip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Central defect of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Central nasal defect" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Midline defect of the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Midline nasal defect" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Central cleft of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004122 ; owl:annotatedTarget "Midline cleft of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004132 ; owl:annotatedTarget "An abnormal indentation of the skin in the region of the nasal tip." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25754 ; owl:annotatedTarget "oxo carboxylic acids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004132 ; owl:annotatedTarget "Dimple on nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004132 ; owl:annotatedTarget "Dimpled tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004150 ; owl:annotatedTarget "An anomaly of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004172 ; owl:annotatedTarget "Abnormal middle finger bone of the middle finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142533 ; owl:annotatedTarget "->4)-alpha-D-galactosyl-(1->4)-beta-D-galactosylp-(1->4)-beta-D-glucosyl" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25798 ; owl:annotatedTarget "oxopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004180 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the distal phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004180 ; owl:annotatedTarget "Short outermost bone of the middle finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25799 ; owl:annotatedTarget "oxopentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004195 ; owl:annotatedTarget "Osteolytic defects of the phalanges of the 4th (ring) finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25799 ; owl:annotatedTarget "oxovaleric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004197 ; owl:annotatedTarget "Fusion of two or more bones of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004197 ; owl:annotatedTarget "Fused ring finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004207 ; owl:annotatedTarget "An abnormality affecting one or both 5th fingers." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004207 ; owl:annotatedTarget "Abnormality of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004207 ; owl:annotatedTarget "Abnormality of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004207 ; owl:annotatedTarget "Abnormality of the pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25801 ; owl:annotatedTarget "oxoproline" . [] oboInOwl:hasDbXref , "PMID:16252026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004209 ; owl:annotatedTarget "Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004209 ; owl:annotatedTarget "Curvature of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004209 ; owl:annotatedTarget "Curvature of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004209 ; owl:annotatedTarget "Curvature of pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004209 ; owl:annotatedTarget "Permanent curving of the pinkie finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004213 ; owl:annotatedTarget "Abnormality of the phalanges of the 5th (little) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004213 ; owl:annotatedTarget "Abnormality of the little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004213 ; owl:annotatedTarget "Abnormality of the pinkie finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "oxygen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004213 ; owl:annotatedTarget "Abnormality of the pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004214 ; owl:annotatedTarget "Curved phalanges of the 5th (little) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004214 ; owl:annotatedTarget "Curved little finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "8O" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004214 ; owl:annotatedTarget "Curved pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004214 ; owl:annotatedTarget "Curved pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "O" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004216 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the phalanges of the 5th finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "Sauerstoff" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004218 ; owl:annotatedTarget "Fusion of two or more bones of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004218 ; owl:annotatedTarget "Fused little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004218 ; owl:annotatedTarget "Fused pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004218 ; owl:annotatedTarget "Fused pinky finger bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "oxigeno" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004219 ; owl:annotatedTarget "Abnormality of the middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004219 ; owl:annotatedTarget "Abnormality of the middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004219 ; owl:annotatedTarget "Abnormality of the middle bone of pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "oxygen" . [] oboInOwl:hasDbXref , "PMID:18494372" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004220 ; owl:annotatedTarget "Hypoplastic/small middle phalanx of the fifth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004220 ; owl:annotatedTarget "Short middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004220 ; owl:annotatedTarget "Short middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004220 ; owl:annotatedTarget "Short middle bone of the pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25805 ; owl:annotatedTarget "oxygene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004222 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the distal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004222 ; owl:annotatedTarget "Cone-shaped end part of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004222 ; owl:annotatedTarget "Cone-shaped end part of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004222 ; owl:annotatedTarget "Cone-shaped end part of the outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25806 ; owl:annotatedTarget "oxygen molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004223 ; owl:annotatedTarget "Sclerosis of the epiphysis of the distal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004223 ; owl:annotatedTarget "Increased bone density of end part of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004223 ; owl:annotatedTarget "Increased bone density of end part of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004223 ; owl:annotatedTarget "Increased bone density of end part of the outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25806 ; owl:annotatedTarget "oxygen molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004224 ; owl:annotatedTarget "Abnormality of the epiphysis of the middle phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25810 ; owl:annotatedTarget "oxopurines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004224 ; owl:annotatedTarget "Abnormality of the end part of middle little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004224 ; owl:annotatedTarget "Abnormality of the end part of middle pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004224 ; owl:annotatedTarget "Abnormality of the end part of middle pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25830 ; owl:annotatedTarget "p-quinone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004225 ; owl:annotatedTarget "Abnormality of the distal phalanx of the 5th (little) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004225 ; owl:annotatedTarget "Abnormality of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004225 ; owl:annotatedTarget "Abnormality of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004225 ; owl:annotatedTarget "Abnormality of the outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25830 ; owl:annotatedTarget "para-quinones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004226 ; owl:annotatedTarget "Curved appearance of the distal phalanx of the 5th (little) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004226 ; owl:annotatedTarget "Curved outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004226 ; owl:annotatedTarget "Curved outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004226 ; owl:annotatedTarget "Curved outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25899 ; owl:annotatedTarget "pentitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004227 ; owl:annotatedTarget "Hypoplastic/small distal phalanx of the fifth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004227 ; owl:annotatedTarget "Short outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004227 ; owl:annotatedTarget "Short outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004227 ; owl:annotatedTarget "Short outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25899 ; owl:annotatedTarget "pentitols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004230 ; owl:annotatedTarget "A partial dislocation of the proximal interphalangeal joint of the little finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004230 ; owl:annotatedTarget "Partially dislocated innermost hinge joint of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004230 ; owl:annotatedTarget "Partially dislocated innermost hinge joint of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004230 ; owl:annotatedTarget "Partially dislocated innermost hinge joint of pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_25901 ; owl:annotatedTarget "pentose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004231 ; owl:annotatedTarget "Congenital absence of a carpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004231 ; owl:annotatedTarget "Absent wrist bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004231 ; owl:annotatedTarget "Missing wrist bone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004231 ; owl:annotatedTarget "Absent carpal ossification centre" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25901 ; owl:annotatedTarget "pentoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004232 ; owl:annotatedTarget "The presence of more than the normal number of carpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004232 ; owl:annotatedTarget "Extra wrist bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004233 ; owl:annotatedTarget "Ossification of carpal bones at an abnormally early age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004233 ; owl:annotatedTarget "Accelerated wrist bone maturation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25905 ; owl:annotatedTarget "peptide hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004234 ; owl:annotatedTarget "The bone-in-bone sign is a radiographic finding produced by increased sclerosis (abnormally dense bone) occurring intermittently with zones of relatively normal bone density. This term should be used to describe such a finding in the carpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004234 ; owl:annotatedTarget "Bone-in-a-bone appearance of wrist bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004235 ; owl:annotatedTarget "Comma-shaped wrist bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_25905 ; owl:annotatedTarget "polypeptide hormone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004236 ; owl:annotatedTarget "Carpal bones with irregular or fragmented margins." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004236 ; owl:annotatedTarget "Irregular wrist bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004237 ; owl:annotatedTarget "Increased size of carpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004237 ; owl:annotatedTarget "Large wrist bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004240 ; owl:annotatedTarget "Hardened spots within wrist bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004240 ; owl:annotatedTarget "Stiffened spots within wrist bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26020 ; owl:annotatedTarget "phosphates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004241 ; owl:annotatedTarget "Point-shaped (punctate) calcifications affecting the carpal bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26020 ; owl:annotatedTarget "phosphates" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004242 ; owl:annotatedTarget "Wide wrist bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "PMID:33643275" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004246 ; owl:annotatedTarget "Formation of bone tissue of scaphoid is less than expected for age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004247 ; owl:annotatedTarget "Underdevelopment of the scaphoid." . [] oboInOwl:hasDbXref "PMID:23853014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004251 ; owl:annotatedTarget "Osseous fusion of the lunate and triquetrum." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Beilstein:1921286" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004252 ; owl:annotatedTarget "An anomaly of trapezium." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "CAS:7664-38-2" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "CAS:7664-38-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004254 ; owl:annotatedTarget "Formation of bone tissue of trapezium is less than expected for age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004255 ; owl:annotatedTarget "Underdevelopment of the trapezium." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "CAS:7664-38-2" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "PMID:7691279" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Drug_Central:4478" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004257 ; owl:annotatedTarget "Formation of bone tissue of trapezoid is less than expected for age." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Gmelin:2000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004258 ; owl:annotatedTarget "Underdevelopment of the trapezoid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:11455380" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:15630224" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004260 ; owl:annotatedTarget "Large unciform bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004261 ; owl:annotatedTarget "Wide unciform bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:17518491" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004267 ; owl:annotatedTarget "Narrow small joints of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004269 ; owl:annotatedTarget "A partial dislocation of some or all of the small joints of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004269 ; owl:annotatedTarget "Partial dislocation of small joints of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004273 ; owl:annotatedTarget "Cupped metaphysis of hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004273 ; owl:annotatedTarget "Cupped wide portion of hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:22282755" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004274 ; owl:annotatedTarget "Deficient maturation of hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:22333268" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004275 ; owl:annotatedTarget "Duplication of hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004276 ; owl:annotatedTarget "Abnormal formation of new bone on the surface of a bone of the hand." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:22381614" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004277 ; owl:annotatedTarget "Broken hand bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004277 ; owl:annotatedTarget "Fractured hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "PMID:22401268" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004278 ; owl:annotatedTarget "An abnormal union between bones or parts of bones of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004278 ; owl:annotatedTarget "Fused hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Reaxys:1921286" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004279 ; owl:annotatedTarget "Short palm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004279 ; owl:annotatedTarget "Short palm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004279 ; owl:annotatedTarget "Short hands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004279 ; owl:annotatedTarget "Short palms" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Phosphoric acid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "phosphoric acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004280 ; owl:annotatedTarget "Irregular maturation of hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "tetraoxophosphoric acid" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004283 ; owl:annotatedTarget "For children from birth to 4 years of age, the palm width is more than 2 SD below the mean; for children from 4 to 16 years of age the palm width is below the 5th centile; or, the width of the palm appears disproportionately narrow for its length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004283 ; owl:annotatedTarget "Narrow palm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004283 ; owl:annotatedTarget "Narrow hands" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "trihydrogen tetraoxophosphate(3-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004284 ; owl:annotatedTarget "Notched hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "trihydroxidooxidophosphorus" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "H3PO4" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004286 ; owl:annotatedTarget "Uneven increase in bone density in hand bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004287 ; owl:annotatedTarget "Pointed hand bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Orthophosphoric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004293 ; owl:annotatedTarget "Fusion of the second metacarpal-trapezoid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004294 ; owl:annotatedTarget "A partial dislocation affecting some or all of the metacarpophalangeal joints." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Phosphate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004294 ; owl:annotatedTarget "Partial knuckle dislocation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004294 ; owl:annotatedTarget "Subluxation of metacarpophalangeal joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004295 ; owl:annotatedTarget "An abnormality of the gastric mucous membrane." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Phosphorsaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004295 ; owl:annotatedTarget "Abnormality of the mucous membrane layer of stomach" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "Gala1-4Galb1-4Glcb-yl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "Phosphorsaeureloesungen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004296 ; owl:annotatedTarget "Abnormality of GI blood vessels" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004296 ; owl:annotatedTarget "Abnormality of GI vasculature" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "[PO(OH)3]" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004297 ; owl:annotatedTarget "An abnormality of the biliary system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004298 ; owl:annotatedTarget "The presence of any abnormality affecting the abdominal wall." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "acide phosphorique" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004298 ; owl:annotatedTarget "Abnormality of the abdominal wall" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004299 ; owl:annotatedTarget "The presence of a hernia in the abdominal wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004299 ; owl:annotatedTarget "Herniated abdominal wall" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "acidum phosphoricum" . [] oboInOwl:hasDbXref , "PMID:22938878" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004303 ; owl:annotatedTarget "Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004303 ; owl:annotatedTarget "Abnormal muscle fibre morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004303 ; owl:annotatedTarget "Abnormal skeletal muscle fibre morphology" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26078 ; owl:annotatedTarget "orthophosphoric acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004303 ; owl:annotatedTarget "Abnormality of muscle fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004305 ; owl:annotatedTarget "Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004305 ; owl:annotatedTarget "Involuntary movements" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004305 ; owl:annotatedTarget "Involuntary muscle contractions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004306 ; owl:annotatedTarget "An abnormality of the endocardium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004308 ; owl:annotatedTarget "Ventricular arrhythmias" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004309 ; owl:annotatedTarget "An abnormality in which the cardiac ventricles depolarize too early as a result of an abnormality of cardiac conduction pathways such as an accessory pathway." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26082 ; owl:annotatedTarget "phosphorus molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004311 ; owl:annotatedTarget "An abnormality of macrophages." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26130 ; owl:annotatedTarget "pigments" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004312 ; owl:annotatedTarget "A reticulocyte abnormality." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26155 ; owl:annotatedTarget "plant growth regulators" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004313 ; owl:annotatedTarget "An abnormally decreased level of immunoglobulin in blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "Galalpha1-4Galbeta1-4Glcbeta-R" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004315 ; owl:annotatedTarget "An abnormally decreased level of immunoglobulin G (IgG) in blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26167 ; owl:annotatedTarget "PMID:12016058" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004319 ; owl:annotatedTarget "Abnormally reduced levels of aldosterone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26167 ; owl:annotatedTarget "polar amino acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004319 ; owl:annotatedTarget "Low blood aldosterone level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26167 ; owl:annotatedTarget "polar amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004320 ; owl:annotatedTarget "The presence of a fistula of the vagina." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26167 ; owl:annotatedTarget "polar amino-acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004321 ; owl:annotatedTarget "The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26167 ; owl:annotatedTarget "polar amino-acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004322 ; owl:annotatedTarget "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004322 ; owl:annotatedTarget "Decreased body height" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004322 ; owl:annotatedTarget "Short stature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004322 ; owl:annotatedTarget "Small stature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26191 ; owl:annotatedTarget "polyols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004323 ; owl:annotatedTarget "An abnormal increase or decrease of weight or an abnormal distribution of mass in the body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004323 ; owl:annotatedTarget "Abnormality of body weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004324 ; owl:annotatedTarget "Increased body weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004324 ; owl:annotatedTarget "Weight gain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26214 ; owl:annotatedTarget "porphyrins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004325 ; owl:annotatedTarget "Decreased body weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004325 ; owl:annotatedTarget "Decreased weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004325 ; owl:annotatedTarget "Low body weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004325 ; owl:annotatedTarget "Low weight" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004325 ; owl:annotatedTarget "Weight less than 3rd percentile" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004326 ; owl:annotatedTarget "Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004326 ; owl:annotatedTarget "Wasting syndrome" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "Galalpha1-4Galbeta1-4Glcbeta-yl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004327 ; owl:annotatedTarget "Any structural anomaly of the vitreous body." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004327 ; owl:annotatedTarget "Abnormal vitreous humour morphology" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "CAS:7440-09-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004328 ; owl:annotatedTarget "An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "potassium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "19K" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "An increase in the magnitude or amount of ossification of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Hyperossification of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Hyperostosis of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Sclerosis of bones of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Sclerosis of skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Increased Mineralization of skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004330 ; owl:annotatedTarget "Increased calcification of skull" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "K" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "Kalium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "A reduction in the magnitude or amount of ossification of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Decreased bone formation of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Hypoossification of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Ossification defect of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Poorly ossified skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Decreased calcification of skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004331 ; owl:annotatedTarget "Decreased mineralization of skull" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "kalium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004332 ; owl:annotatedTarget "An abnormality of lymphocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004333 ; owl:annotatedTarget "The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "potasio" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004334 ; owl:annotatedTarget "Partial or complete wasting (atrophy) of the skin." . [] a owl:Axiom ; rdfs:label "Skin atrophy" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0004334 ; owl:annotatedTarget "MEDDRA:10040799" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004334 ; owl:annotatedTarget "Skin degeneration" . [] oboInOwl:hasDbXref , "PMID:10932274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004336 ; owl:annotatedTarget "The presence of excessive redundant myelin in the peripheral nerve sheath." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26216 ; owl:annotatedTarget "potassium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004337 ; owl:annotatedTarget "Abnormality of an amino acid metabolic process." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004338 ; owl:annotatedTarget "Any deviation from the normal concentration of a aromatic amino acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc-yl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26217 ; owl:annotatedTarget "potassium molecular entity" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004339 ; owl:annotatedTarget "Any deviation from the normal concentration of a sulfur amino acid in the blood circulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004339 ; owl:annotatedTarget "Abnormal circulating sulphur amino acid concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26217 ; owl:annotatedTarget "potassium molecular entities" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004342 ; owl:annotatedTarget "Abnormality of galactoside metabolism. A galactoside is a glycoside (a suger moiety bound to some other moiety) containing galactose." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004343 ; owl:annotatedTarget "An abnormality of glycosphingolipid metabolism." . [] oboInOwl:hasDbXref , "PMID:21937853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004345 ; owl:annotatedTarget "Defects in the lysosomal glycosidases or specific co-activators, result in accumulation of the substrates, such as glycosphingolipids, including gangliosides in GM1 gangliosidosis (Tay-Sachs disease) and GM2 gangliosidosis (Sandhoff disease)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004347 ; owl:annotatedTarget "Reduced function of the muscles required to generate subatmospheric pressure in the thoracic cavity during breathing: the diaphragm, the external intercostal and the interchondral part of the internal intercostal muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004348 ; owl:annotatedTarget "This term applies to all changes in bone mineral density which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone. Changes may affect all bones of the organism, just certain bones or only parts of bones and include decreased mineralisation as may be seen in osteoporosis or increased mineralisation and or ossification as in osteopetrosis, exostoses or any kind of atopic calicfications of different origin and distribution. The overall amount of mineralization of the bone-organ can be measured as the amount of matter per cubic centimeter of bones, usually measured by densitometry of the lumbar spine or hip. The measurements are usually reported as g/cm3 or as a Z-score (the number of standard deviations above or below the mean for the patient's age and sex). Note that measurement with this method does not reflect local changes in other bones, and as such might not be correct with regard the hole bone-organ." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004349 ; owl:annotatedTarget "A reduction of bone mineral density, that is, of the amount of matter per cubic centimeter of bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004349 ; owl:annotatedTarget "Decreased bone mineral density" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "Beilstein:80809" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004349 ; owl:annotatedTarget "Low solidness and mass of the bones" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "CAS:609-36-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004353 ; owl:annotatedTarget "Any deviation from the normal concentration of a pyrimidine in the blood circulation." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "CAS:609-36-9" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004354 ; owl:annotatedTarget "Any deviation from the normal concentration of a carboxylic acid in the blood circulation." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "CAS:609-36-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004357 ; owl:annotatedTarget "Any deviation from the normal circulation of leucine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142567 ; owl:annotatedTarget "alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "Gmelin:26927" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:16534801" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004359 ; owl:annotatedTarget "A deviation from the normal concentration of a fatty acid in the blood circulation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:21400017" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004360 ; owl:annotatedTarget "An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:21903295" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004361 ; owl:annotatedTarget "An abnormal concentration of leptin in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004362 ; owl:annotatedTarget "An abnormality of the enteric nervous system, which comprises two types of ganglia, the myenteric (Auerbach's) and submucosal (Meissner's) plexuses. The enteric nervous system functions to control gut movement, fluid exchange between the gut and its lumen, and local blood flow." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:22280966" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004363 ; owl:annotatedTarget "Any deviation from the normal concentration of calcium in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004363 ; owl:annotatedTarget "Abnormal blood calcium concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004363 ; owl:annotatedTarget "Abnormal blood calcium levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004363 ; owl:annotatedTarget "Abnormal circulating Ca concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004363 ; owl:annotatedTarget "Abnormal circulating Ca2+ concentration" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "Reaxys:80809" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004364 ; owl:annotatedTarget "Any deviation from the normal concentration of a nitrogen compound in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004365 ; owl:annotatedTarget "Any deviation from the normal concentration of tryptophan in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "proline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004366 ; owl:annotatedTarget "An abnormality of glycolysis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "proline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004368 ; owl:annotatedTarget "Increased purine levels" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "DL-Proline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004369 ; owl:annotatedTarget "Decreased purine levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "Hpro" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004370 ; owl:annotatedTarget "An abnormality of temperature homeostasis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004370 ; owl:annotatedTarget "Abnormality of temperature regulation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004370 ; owl:annotatedTarget "Poor temperature regulation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004370 ; owl:annotatedTarget "Body temperature changes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "Prolin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004371 ; owl:annotatedTarget "Abnormality of glycosaminoglycan metabolism." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004372 ; owl:annotatedTarget "Disturbances of consciousness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004372 ; owl:annotatedTarget "Lowered consciousness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004372 ; owl:annotatedTarget "Reduced consciousness/confusion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "prolina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004373 ; owl:annotatedTarget "A type of dystonia that is localized to a specific part of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004374 ; owl:annotatedTarget "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a severe or complete loss of strength, whereas hemiparesis refers to a relatively mild loss of strength." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004374 ; owl:annotatedTarget "Paralysis or weakness of one side of body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004375 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004375 ; owl:annotatedTarget "Tumor of the nervous system" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004375 ; owl:annotatedTarget "Tumour of the nervous system" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004375 ; owl:annotatedTarget "Nervous system cancer" . [] oboInOwl:hasDbXref "PMID:27823645" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004376 ; owl:annotatedTarget "A family of tumors arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004376 ; owl:annotatedTarget "Neuroblastic tumour" . [] oboInOwl:hasDbXref "http://www.ncbi.nlm.nih.gov/mesh?term=Hematologic%20Neoplasms" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004377 ; owl:annotatedTarget "Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26271 ; owl:annotatedTarget "pyrrolidine-2-carboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004377 ; owl:annotatedTarget "Blood tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004377 ; owl:annotatedTarget "Blood tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004377 ; owl:annotatedTarget "Haematological neoplasm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004378 ; owl:annotatedTarget "Abnormality of the anal canal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004378 ; owl:annotatedTarget "Abnormality of the anus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004379 ; owl:annotatedTarget "An abnormality of alkaline phosphatase level." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26273 ; owl:annotatedTarget "proline derivatives" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004379 ; owl:annotatedTarget "Abnormality of ALP level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004380 ; owl:annotatedTarget "Deposition of calcium salts in the aortic valve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004381 ; owl:annotatedTarget "A pathological narrowing in the region above the aortic valve associated with restricted left ventricular outflow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004382 ; owl:annotatedTarget "Abnormal calcification of the mitral valve." . [] oboInOwl:hasDbXref , "PMID:22192721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004383 ; owl:annotatedTarget "Underdevelopment of the left side of the heart. May include atresia of the aortic or mitral orifice and hypoplasia of the ascending aorta." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26333 ; owl:annotatedTarget "CAS:11000-26-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004383 ; owl:annotatedTarget "Underdeveloped left heart" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004384 ; owl:annotatedTarget "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with a short pulmonary trunk arises from the truncus arteriosus, giving rise to both pulmonary arteries." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004385 ; owl:annotatedTarget "Protracted diarrhoea" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26333 ; owl:annotatedTarget "LIPID_MAPS_class:LMFA0301" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004386 ; owl:annotatedTarget "GI inflammation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004386 ; owl:annotatedTarget "Gastrointestinal inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004387 ; owl:annotatedTarget "An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26333 ; owl:annotatedTarget "prostaglandin" . [] oboInOwl:hasDbXref "PMID:3484569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004388 ; owl:annotatedTarget "A colon of abnormally small caliber." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004388 ; owl:annotatedTarget "Microcolon on contrast enema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004389 ; owl:annotatedTarget "A functional rather than mechanical obstruction of the intestines, associated with manifestations that resemble those caused by an intestinal obstruction, including distension, abdominal pain, nausea, vomiting, constipation or diarrhea, in an individual in whom a mechanical blockage has been excluded." . [] oboInOwl:hasDbXref , "PMID:17768394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004390 ; owl:annotatedTarget "Polyp-like protrusions which are histologically hamartomas. These can occur throughout the gastrointestinal tract. Hamartomatous polyps are composed of the normal cellular elements of the gastrointestinal tract, but have a markedly distorted architecture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004390 ; owl:annotatedTarget "Gastrointestinal hamartomatous polyps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004392 ; owl:annotatedTarget "A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26333 ; owl:annotatedTarget "prostaglandins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004392 ; owl:annotatedTarget "Prune belly" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004395 ; owl:annotatedTarget "Malnutrition" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004396 ; owl:annotatedTarget "Decreased appetite" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004396 ; owl:annotatedTarget "Poor appetite" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004396 ; owl:annotatedTarget "No appetite" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26333 ; owl:annotatedTarget "prostaglandins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004397 ; owl:annotatedTarget "Abnormal displacement or malposition of the anus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004397 ; owl:annotatedTarget "Abnormal anus position" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26338 ; owl:annotatedTarget "PGE" . [] oboInOwl:hasDbXref , "PMID:28242110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004398 ; owl:annotatedTarget "The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the oesophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004398 ; owl:annotatedTarget "Sore in the lining of gastrointestinal tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004399 ; owl:annotatedTarget "Congenital atresia of the pylorus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26347 ; owl:annotatedTarget "prostanoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004400 ; owl:annotatedTarget "An abnormality of the pylorus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004401 ; owl:annotatedTarget "Obstruction of the intestine due to abnormally thick meconium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004401 ; owl:annotatedTarget "Meconium ileus on ultrasonography" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26347 ; owl:annotatedTarget "prostanoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004404 ; owl:annotatedTarget "An abnormality of the nipple." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004404 ; owl:annotatedTarget "Abnormality of the nipple" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26347 ; owl:annotatedTarget "prostanoids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004405 ; owl:annotatedTarget "Prominent nipples" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004406 ; owl:annotatedTarget "Recurring nosebleed" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004406 ; owl:annotatedTarget "Spontaneous, recurrent nosebleed" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26348 ; owl:annotatedTarget "prosthetic group" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004408 ; owl:annotatedTarget "Abnormal sense of smell" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004408 ; owl:annotatedTarget "Abnormality of the sense of smell" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004408 ; owl:annotatedTarget "Smell defect" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_142590 ; owl:annotatedTarget "3-azaniumyl-2-methylpropanoate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26348 ; owl:annotatedTarget "groupe prosthetique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004409 ; owl:annotatedTarget "A decreased sensitivity to odorants (that is, a decreased ability to perceive odors)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004411 ; owl:annotatedTarget "Positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004411 ; owl:annotatedTarget "Crooked nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004411 ; owl:annotatedTarget "Crooked septum of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004411 ; owl:annotatedTarget "Deviated nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004411 ; owl:annotatedTarget "Deviated septum of nose" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26348 ; owl:annotatedTarget "prosthetic groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004414 ; owl:annotatedTarget "An abnormality of the pulmonary artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004414 ; owl:annotatedTarget "Abnormality of lung artery" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26386 ; owl:annotatedTarget "purine nucleobase" . [] oboInOwl:hasDbXref , "PMID:30587259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004415 ; owl:annotatedTarget "An abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004415 ; owl:annotatedTarget "Narrowing of lung artery" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004416 ; owl:annotatedTarget "Premature plaque build-up in arteries" . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004417 ; owl:annotatedTarget "Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004418 ; owl:annotatedTarget "Inflammation of a vein associated with venous thrombosis (blood clot formation within the vein)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004419 ; owl:annotatedTarget "Repeated episodes of inflammation of a vein associated with venous thrombosis (blood clot formation within the vein)." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26386 ; owl:annotatedTarget "a purine nucleobase" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004420 ; owl:annotatedTarget "The formation of a blood clot inside an artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004420 ; owl:annotatedTarget "Blood clot in artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004421 ; owl:annotatedTarget "Abnormal increase in systolic blood pressure." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004421 ; owl:annotatedTarget "Elevated systolic BP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26386 ; owl:annotatedTarget "purine bases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004422 ; owl:annotatedTarget "A narrowing of the biparietal diameter (i.e., of the transverse distance between the protuberances of the two parietal bones of the skull)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004422 ; owl:annotatedTarget "Decreased width of the skull" . [] oboInOwl:hasDbXref "PMID:28522383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004423 ; owl:annotatedTarget "Cranium bifidum occultum, also known as Catlin mark, is a congenital midline skull defect presenting as an enlarged posterior fontanelle in the upper posterior angle of the parietal bone close to the intersection of the sagittal and lambdoid sutures.1, 2, 3 Cranium bifidum occultum occurs due to a defect in intramembranous ossification, a process through which skull bones (frontal, parietal, squamous temporal and occipital bones superior to the mendosal suture) ossify under a vascularized membrane toward the midline to cover the brain.1, 4, 5 Unlike cranium bifidum cysticum, cranium bifidum occultum does not have herniation of intracranial contents. As the skull grows, the midline cranium bifidum occultum defect is separated into bilateral enlarged parietal foramina (EPF) by a midline osseous bridge." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26386 ; owl:annotatedTarget "purine nucleobases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004425 ; owl:annotatedTarget "A forehead with abnormal flatness." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004425 ; owl:annotatedTarget "Flat forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004425 ; owl:annotatedTarget "Flattened forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004425 ; owl:annotatedTarget "Frontal flattening" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26432 ; owl:annotatedTarget "pyrimidine nucleobase" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004426 ; owl:annotatedTarget "Abnormality of the cheek" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004426 ; owl:annotatedTarget "Abnormality of the cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0004426 ; owl:annotatedTarget "Anomaly of the cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0004426 ; owl:annotatedTarget "Deformity of the cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0004426 ; owl:annotatedTarget "Malformation of the cheeks" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004428 ; owl:annotatedTarget "This is a description previously used to describe a facial form characterized by a short, upturned nose, wide mouth, widely spaced eyes, and full cheeks. Because of the imprecision in this definition it is preferable to describe these features precisely. This term is retained because it was often used in the past, but it should not be used for new annotations." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004428 ; owl:annotatedTarget "Elf-like facial appearance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004428 ; owl:annotatedTarget "Elf-like facial features" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004428 ; owl:annotatedTarget "Leprechaun facies" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26432 ; owl:annotatedTarget "a pyrimidine nucleobase" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004429 ; owl:annotatedTarget "Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004430 ; owl:annotatedTarget "A type of primary immune deficiency that is characterized by a more severe defect in both the T- and B-lymphocyte systems." . [] oboInOwl:hasDbXref "PMID:24161035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004431 ; owl:annotatedTarget "An immunodeficiency defined by the absent or suboptimal functioning of one of the complement system proteins." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26432 ; owl:annotatedTarget "pyrimidine bases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004432 ; owl:annotatedTarget "A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured." . [] oboInOwl:hasDbXref , "PMID:2251975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004433 ; owl:annotatedTarget "Deficiency of secretory IgA (polymers of 2-4 IgA monomers are linked by two additional chains) and is the primary antibody response at the mucosal level, where it forms immune complexes with pathogens and allergens." . [] oboInOwl:hasDbXref "PMID:8098723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004434 ; owl:annotatedTarget "Concentration of the complement component C8 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26432 ; owl:annotatedTarget "pyrimidine nucleobases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Excessive growth of the bones of cranium, i.e., of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Enlargement of skull bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Excessive growth of skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Hypertrophy of cranial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Overgrowth of skull bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Thick skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Hyperostosis of cranial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004437 ; owl:annotatedTarget "Increased ossification of cranial bones" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142590 ; owl:annotatedTarget "3-aminoisobutanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26447 ; owl:annotatedTarget "pyrimidinemonocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Bony overgrowth of the internal (endosteal) surface of the frontal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Enlargement of the inner surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Hypertrophy of the internal surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Increased ossification of the internal surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Overgrowth of the inside of the frontal bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26456 ; owl:annotatedTarget "pyrrolidine alkaloids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Thick inner surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Thick internal surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Excessive growth of inner surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Hyperostosis of the internal surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004438 ; owl:annotatedTarget "Overgrowth of the inner surface of the frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004439 ; owl:annotatedTarget "A characteristic appearance resulting from defective ossification of craniofacial bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004439 ; owl:annotatedTarget "Crouzon syndrome" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26463 ; owl:annotatedTarget "pyruvate family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004440 ; owl:annotatedTarget "Premature closure of the coronal suture of skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004440 ; owl:annotatedTarget "Coronal suture craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004440 ; owl:annotatedTarget "Coronal suture synostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004442 ; owl:annotatedTarget "A kind of craniosynostosis affecting the sagittal suture." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004442 ; owl:annotatedTarget "Early closure of midline skull joint" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004442 ; owl:annotatedTarget "Midline skull joint closes early" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004442 ; owl:annotatedTarget "Sagittal suture synostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004443 ; owl:annotatedTarget "A kind of craniosynostosis affecting the lambdoidal suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004443 ; owl:annotatedTarget "Lambdoid suture synostosis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26537 ; owl:annotatedTarget "retinoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004444 ; owl:annotatedTarget "The presence of erythrocytes that are sphere-shaped." . [] oboInOwl:hasDbXref , "PMID:16304353", "PMID:21250106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004445 ; owl:annotatedTarget "The presence of elliptical, cigar-shaped erythrocytes on peripheral blood smear." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/hereditary_elliptocytosis" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004445 ; owl:annotatedTarget "Ovalocytosis" . [] oboInOwl:hasDbXref , "PMID:16304353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004446 ; owl:annotatedTarget "The presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26537 ; owl:annotatedTarget "retinoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004447 ; owl:annotatedTarget "The presence of abnormally shaped erythrocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004448 ; owl:annotatedTarget "Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as fulminant if there is onset of encephalopathy within 4 weeks of the onset of symptoms in a patient with a previously healthy liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004450 ; owl:annotatedTarget "A groove of the skin immediately in front of the ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004450 ; owl:annotatedTarget "Preauricular skin groove" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004450 ; owl:annotatedTarget "Preauricular skin sulcus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26537 ; owl:annotatedTarget "retinoids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004450 ; owl:annotatedTarget "Skin groove in front of the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004450 ; owl:annotatedTarget "Skin sulcus in front of the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004451 ; owl:annotatedTarget "A rudimentary tag of ear tissue often containing a core of cartilage and located just in back of the auricle (outer part of the ear)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004451 ; owl:annotatedTarget "Postauricular acrochordon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004451 ; owl:annotatedTarget "Postauricular fibroepithelial polyp" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004451 ; owl:annotatedTarget "Skin tag behind the ear" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "PMID:16492686" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004452 ; owl:annotatedTarget "An abnormality of the middle-ear ossicles (three small bones called malleus, incus, and stapes) that are contained within the middle ear and serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004453 ; owl:annotatedTarget "A condition in which the superior portion of the helix is folded over to a greater degree than normal." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "PMID:19763019" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004458 ; owl:annotatedTarget "The presence of a dilated inner part of external acoustic meatus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004459 ; owl:annotatedTarget "A benign bony growth projecting outward from a bone surface within the external auditory canal." . [] oboInOwl:hasDbXref "PMID:6958333" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004461 ; owl:annotatedTarget "Pits in the earlobes at the location where ears are typically pierced for earrings." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004463 ; owl:annotatedTarget "Lack of measurable response to stimulation of auditory evoked potentials." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004464 ; owl:annotatedTarget "Benign congenital lesion of the postauricular soft tissue consisting of a blind-ending narrow tube or pit." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004464 ; owl:annotatedTarget "Pit behind the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004464 ; owl:annotatedTarget "Postauricular earpits" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004467 ; owl:annotatedTarget "Small indentation anterior to the insertion of the ear." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142590 ; owl:annotatedTarget "3-ammonio-2-methylpropanoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "PMID:20237329" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004467 ; owl:annotatedTarget "Ear pit" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004467 ; owl:annotatedTarget "Pit in front of the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004469 ; owl:annotatedTarget "Chronic inflammation of the bronchi." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004470 ; owl:annotatedTarget "A congenital defect in the occipital region of the skull, covered by skin of the scalp and containing meninges or remnants of glial or neural tissues." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004471 ; owl:annotatedTarget "A developmental defect resulting in the congenital absence of skin on the scalp vertex, often just lateral to the midline." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004471 ; owl:annotatedTarget "Absent cutis congenita of vertex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Hyperostosis (bony overgrowth) of the mandible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Excessive growth of mandibular bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Overgrowth of mandibular bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Thick lower jaw bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "saturated fatty acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Thick mandibular bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Hyperostosis of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Hyperostosis of mandibular bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Increased ossification of mandibular bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Increased ossification of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004472 ; owl:annotatedTarget "Increased ossification of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004474 ; owl:annotatedTarget "The anterior fontanelle generally ossifies by around the 18th month of life. A persistent open anterior fontanelle is diagnosed if closure is delayed beyond this age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004474 ; owl:annotatedTarget "Front fontanelle stays open" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004476 ; owl:annotatedTarget "A developmental defect resulting in the congenital absence of skin on the scalp in the parietal area." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004476 ; owl:annotatedTarget "Absent cutis congenita over parietal area" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "SFA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "SFAs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26607 ; owl:annotatedTarget "saturated fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004481 ; owl:annotatedTarget "The progressive development of an abnormally large skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004481 ; owl:annotatedTarget "Progressively abnormally enlarging cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004481 ; owl:annotatedTarget "Progressively abnormally enlarging skull" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26650 ; owl:annotatedTarget "PMID:20709681" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004482 ; owl:annotatedTarget "A relatively mild degree of macrocephaly in which the head circumference is not above two standard deviations from the mean, but appears dysproportionately large when other factors such as body stature are taken into account." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004482 ; owl:annotatedTarget "Relatively large head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004484 ; owl:annotatedTarget "Asymmetry of the bones of the skull and the face." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26650 ; owl:annotatedTarget "3-phosphoglycerate family amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004484 ; owl:annotatedTarget "Uneven craniofacial structures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004484 ; owl:annotatedTarget "Abnormality of craniofacial shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004484 ; owl:annotatedTarget "Malformation of craniofacial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004485 ; owl:annotatedTarget "Stagnation of head growth seen as flattening of the head circumference curve." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004485 ; owl:annotatedTarget "Skull stopped growing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004485 ; owl:annotatedTarget "Cranium stopped growing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004485 ; owl:annotatedTarget "Head stopped growing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004487 ; owl:annotatedTarget "An abnormality of head shape characterized by the presence of a short, wide head as well as a pointy or conical form of the top of the head owing to premature closure of the coronal and lambdoid sutures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "The presence of an abnormally large skull with onset at birth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big head present at birth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26650 ; owl:annotatedTarget "3-phosphoglycerate family amino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big head present since birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Congenital large head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large head present at birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large head present since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big cranium present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big cranium present since birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big skull present at birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Big skull present since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Congenital large cranium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Congenital large skull" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26650 ; owl:annotatedTarget "serine family amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large cranium present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large cranium present since birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large skull present at birth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004488 ; owl:annotatedTarget "Large skull present since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Excessive growth of the calvaria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Enlargement of calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Excessive growth of calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Hypertrophy of calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Overgrowth of calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Thick calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Hyperostosis of calvarial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Increased ossification of calvarial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004490 ; owl:annotatedTarget "Overgrowth of skullcap" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "PMID:16633129" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004491 ; owl:annotatedTarget "An enlargement of the posterior fontanelle relative to age-dependent norms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004492 ; owl:annotatedTarget "An abnormally increased width of the cranial fontanelles and sutures." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "PMID:16870803" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Excessive growth of the craniofacial bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Enlargement of craniofacial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Excessive growth of craniofacial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Hypertrophy of craniofacial bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "PMID:18203540" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Overgrowth of craniofacial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Thick craniofacial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Excessive bone growth of the skull and face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Hyperostosis of craniofacial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004493 ; owl:annotatedTarget "Increased ossification of craniofacial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004499 ; owl:annotatedTarget "Chronic nasal inflammation due to narrow nasal airway" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004502 ; owl:annotatedTarget "Bilateral absence (atresia) of the posterior nasal aperture (choana)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004502 ; owl:annotatedTarget "Bilateral blockage of the rear opening of the nasal cavity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004502 ; owl:annotatedTarget "Bilateral obstruction of the rear opening of the nasal cavity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "PMID:20148677" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004510 ; owl:annotatedTarget "Hyperplasia of the islets of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "SCFA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004523 ; owl:annotatedTarget "Increased length of the hairs of the eyebrows." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004523 ; owl:annotatedTarget "Elongated eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004523 ; owl:annotatedTarget "Increased horizontal length of eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004523 ; owl:annotatedTarget "Increased transverse length of eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004523 ; owl:annotatedTarget "Long eyebrows" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004524 ; owl:annotatedTarget "Reduced or lacking hair growth in the temporal region (i.e., around the temples on the side of the skull)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "SCFAs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004524 ; owl:annotatedTarget "Reduced hair growth in temporal region" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004527 ; owl:annotatedTarget "Large clumps of pigment irregularly distributed along hair shaft" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26666 ; owl:annotatedTarget "short-chain fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004528 ; owl:annotatedTarget "Reduced or lacking hair growth in a generalized distribution." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004528 ; owl:annotatedTarget "Generalised hypotrichosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004528 ; owl:annotatedTarget "Hypotrichosis, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004532 ; owl:annotatedTarget "Excessive, increased hair growth located in the sacral region." . [] oboInOwl:hasDbXref , "PMID:20400390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004535 ; owl:annotatedTarget "Anterior cervical hypertrichosis (ACH) or 'hairy throat' refers to the presence of a tuft of terminal hair on the anterior neck, just above the laryngeal prominence." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004540 ; owl:annotatedTarget "A confluent, generalized overgrowth of silvery blonde to gray lanugo hair at birth." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004540 ; owl:annotatedTarget "Congenital generalised hypertrichosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004540 ; owl:annotatedTarget "Congenital, generalised hypertrichosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004552 ; owl:annotatedTarget "Cicatricial alopecia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004552 ; owl:annotatedTarget "Hair loss on scalp from scarring condition" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004554 ; owl:annotatedTarget "Generalized excessive, abnormal hairiness." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004554 ; owl:annotatedTarget "Generalised hypertrichosis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26667 ; owl:annotatedTarget "Sialsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004558 ; owl:annotatedTarget "A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the cervical spine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26667 ; owl:annotatedTarget "Sialsaeuren" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Increased bone density affecting the bones of the spine (vertebral column)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Increased density of spinal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Ivory spinal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Compact spinal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Concrete spinal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Dense spinal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Eburnation of spinal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004563 ; owl:annotatedTarget "Sclerosis of spinal bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26667 ; owl:annotatedTarget "acide sialique" . [] oboInOwl:hasDbXref , "PMID:16167086" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004566 ; owl:annotatedTarget "Bulbous appearance of the anterior vertebral bodies, such that the vertebral bodies have the greatest vertical height anteriorly as well as bulbous anterior superior-inferior contours." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26667 ; owl:annotatedTarget "acides sialique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004568 ; owl:annotatedTarget "Anterior tongue-like protrusions of the vertebral bodies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26667 ; owl:annotatedTarget "sialic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004570 ; owl:annotatedTarget "Increased top to bottom height of vertebral bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004573 ; owl:annotatedTarget "An abnormality of the shape of the thoracic vertebra T11 such that it is wedge-shaped (narrow towards the front)." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "CAS:7440-23-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004576 ; owl:annotatedTarget "Sclerosis (increased density) affecting vertebral end plates." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004580 ; owl:annotatedTarget "An excessive concavity of the anterior surface of one or more vertebral bodies." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "Gmelin:16221" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004586 ; owl:annotatedTarget "Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "sodium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "11Na" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004590 ; owl:annotatedTarget "Small sacrum" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "Na" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004592 ; owl:annotatedTarget "A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the thoracic spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004598 ; owl:annotatedTarget "Three ossification sites are present in typical vertebral bodies (C3-L5): a single ossification center in the vertebral body, and one each in the two neural arches. This term applies if there are additional vertebral ossification centers present during the development and maturation of the spine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004598 ; owl:annotatedTarget "Supernumerary vertebral ossification centres" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "PMID:7534889" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "Natrium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004601 ; owl:annotatedTarget "The closed form of spina bifida with incomplete closure of the vertebra L5 with intact overlying skin." . _:genid53004 oboInOwl:hasDbXref ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004602 ; owl:annotatedTarget "Fusion of cervical vertebrae at C2 and C3, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0001075 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "natrium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004605 ; owl:annotatedTarget "A lack of bone mineralization of the vertebral bodies." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "sodio" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0004606 ; owl:annotatedTarget _:genid53004 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004606 ; owl:annotatedTarget "A lack of ossification of the vertebral bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004607 ; owl:annotatedTarget "Anterior tongue-like protrusions of the lower thoracic vertebral bodies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26708 ; owl:annotatedTarget "sodium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004608 ; owl:annotatedTarget "Anterior mislocalization of the dens of the axis." . [] oboInOwl:hasDbXref , "PMID:3160275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004610 ; owl:annotatedTarget "An abnormal narrowing of the lumbar spinal canal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26712 ; owl:annotatedTarget "sodium compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004614 ; owl:annotatedTarget "The closed form of spina bifida with incomplete closure of S1 with intact overlying skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26712 ; owl:annotatedTarget "sodium molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004616 ; owl:annotatedTarget "A discontinuity of the vertebral arch, i.e., of the posterior part of a vertebra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004617 ; owl:annotatedTarget "Butterfly vertebrae have a cleft through the body of the vertebrae and a funnel shape at the ends." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004621 ; owl:annotatedTarget "Increased size of the vertebral pedicle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004622 ; owl:annotatedTarget "A progressive form of decreased height of the intervertebral disk." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26714 ; owl:annotatedTarget "Natriumsalz" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004625 ; owl:annotatedTarget "Presence of abnormal convexity of the upper and lower end plates of the vertebrae, i.e., an exaggerated bulging out of the upper and lower vertebral end plates." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26714 ; owl:annotatedTarget "Natriumsalze" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26714 ; owl:annotatedTarget "sodium salts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004629 ; owl:annotatedTarget "Reduced size of cervical vertebrae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004630 ; owl:annotatedTarget "Anterior tongue-like protrusions of thoracic vertebral bodies." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004631 ; owl:annotatedTarget "Inability to touch chin to chest" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26739 ; owl:annotatedTarget "sphingolipids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004632 ; owl:annotatedTarget "An abnormality related to a defect of vertebral separation of cervical vertebrae during development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004633 ; owl:annotatedTarget "Over curvature of the lower thoracic region, leading to a round back or if sever to a hump." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004633 ; owl:annotatedTarget "Round mid-back" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004635 ; owl:annotatedTarget "Fusion of the C5 and C6 cervical vertebrae." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "Steroidhormon" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004637 ; owl:annotatedTarget "Limited neck movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004639 ; owl:annotatedTarget "An elevation of alpha-feto protein measured in the amniotic fluid." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/alpha-fetoprotein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004639 ; owl:annotatedTarget "Elevated amniotic fluid alpha fetal protein" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004639 ; owl:annotatedTarget "Elevated amniotic fluid alpha foetal protein" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/alpha-fetoprotein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004639 ; owl:annotatedTarget "Elevated amniotic fluid alpha-1-fetoprotein" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/alpha-fetoprotein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004639 ; owl:annotatedTarget "Elevated amniotic fluid alpha-fetoglobulin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "Steroidhormone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Underdevelopment of the nasal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Small nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Decreased size of nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Deficiency of nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Underdevelopment of nasal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004646 ; owl:annotatedTarget "Hypotrophic nasal bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "hormona esteroide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "hormonas esteroideas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Underdevelopment of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Small facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Decreased size of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Deficiency of facial musculature" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Underdevelopment of facial muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Atrophy of facial musculature" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004660 ; owl:annotatedTarget "Hypotrophic facial musculature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "hormone steroide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004661 ; owl:annotatedTarget "Reduced strength of the frontalis muscle (which is located on the forehead)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004661 ; owl:annotatedTarget "Weakness of forehead muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004664 ; owl:annotatedTarget "Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the midline region of the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004673 ; owl:annotatedTarget "A reduced degree of voluntary and involuntary facial movements involved in responded to others or expressing emotions." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004673 ; owl:annotatedTarget "Decreased facial expression" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "hormones steroides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004679 ; owl:annotatedTarget "Large ankle bones" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004681 ; owl:annotatedTarget "Narrow, paramedian longitudinal depressions in the plantar skin of the forefoot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004681 ; owl:annotatedTarget "Foot crease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004684 ; owl:annotatedTarget "Outward turning of the heel, resulting in clubfoot with the person walking on the inner part of the foot." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26764 ; owl:annotatedTarget "steroid hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004686 ; owl:annotatedTarget "Underdevelopment of the Third metatarsal bone leading to a short (hypoplastic) third metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004686 ; owl:annotatedTarget "Short 3rd long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "3'-sialyllactosyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26819 ; owl:annotatedTarget "sulfate ester" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004688 ; owl:annotatedTarget "Abnormal shape of ankle bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26819 ; owl:annotatedTarget "sulfuric acid ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004689 ; owl:annotatedTarget "Short fourth metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004689 ; owl:annotatedTarget "Short 4th long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004689 ; owl:annotatedTarget "Short fourth metatarsals" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26819 ; owl:annotatedTarget "sulfuric acid esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004690 ; owl:annotatedTarget "An abnormal thickening of the Achilles tendon." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004690 ; owl:annotatedTarget "Thickened Achilles tendon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26820 ; owl:annotatedTarget "sulfates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004691 ; owl:annotatedTarget "Syndactyly with fusion of toes two and three." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004691 ; owl:annotatedTarget "Toe syndactyly, 2-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004691 ; owl:annotatedTarget "Webbed 2nd and 3rd toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26820 ; owl:annotatedTarget "sulfuric acid derivative" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004692 ; owl:annotatedTarget "Syndactyly with fusion of toes four and five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004692 ; owl:annotatedTarget "Webbed 4th-5th toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004695 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the calcaneus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26820 ; owl:annotatedTarget "sulphates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004699 ; owl:annotatedTarget "Decrease in mass and density of the metatarsal bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26822 ; owl:annotatedTarget "sulphides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004704 ; owl:annotatedTarget "Short (hypoplastic) fifth metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004704 ; owl:annotatedTarget "Short 5th long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004712 ; owl:annotatedTarget "An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004712 ; owl:annotatedTarget "Abnormal rotation of the kidneys" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004713 ; owl:annotatedTarget "Acute renal failure with resolution of manifestations." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004713 ; owl:annotatedTarget "Reversible kidney failure" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "CAS:7704-34-9" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004713 ; owl:annotatedTarget "Reversible renal failure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004717 ; owl:annotatedTarget "An abnormality of the normal developmental rotation of the kidney leading to an abnormal axial orientation of the kidney." . [] oboInOwl:hasDbXref , "PMID:2259758", "PMID:24235286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004719 ; owl:annotatedTarget "An increase in amplitude of waves returned in ultrasonography of the kidney, which is generally displayed as increased brightness of the signal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004722 ; owl:annotatedTarget "Prominent glomerular basement membrane (GBM), reflecting an increase in thickness (subjective estimate) of the basal lamina of the glomerulus of the kidney." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "CAS:7704-34-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "The presence of calcium-containing calculi (stones) in the kidneys." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "Ca kidney stone" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "Ca nephrolithiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "Ca2+ kidney stone" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "Ca2+ nephrolithiasis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004724 ; owl:annotatedTarget "Calcium kidney stone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004727 ; owl:annotatedTarget "A defect in the ability to concentrate the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004729 ; owl:annotatedTarget "Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004732 ; owl:annotatedTarget "A reduction in the ability of the kidneys to remove uric acid from the serum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "Neu5Acalpha2-3Galbeta1-4Glcbeta-yl" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "sulfur" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004734 ; owl:annotatedTarget "Cysts of microscopic size confined to the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004736 ; owl:annotatedTarget "A developmental anomaly in which the kidneys are fused and localized on the same side of the midline. This anomaly is thought to result from disruption of the normal embryologic migration of the kidneys." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004737 ; owl:annotatedTarget "Obliteration of the glomerular capillary lumen by increased collagenous matrix, with or without hyalinosis or foam cells. Sclerosis involves 100% of the glomerular tuft. Relative to other patent glomeruli in the sample, glomerular size is preserved, or increased/decreased by no more than 50%." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "16S" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004742 ; owl:annotatedTarget "An abnormality of the renal collecting system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004743 ; owl:annotatedTarget "Chronic inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl", "PMID:20301598", "PMID:30085237" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004746 ; owl:annotatedTarget "Electron dense deposits at the glomerular basement membrane," . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004749 ; owl:annotatedTarget "A type of atrial arrhythmia characterized by atrial rates of between 240 and 400 beats per minute and some degree of atrioventricular node conduction block. Typically, the ventricular rate is half the atrial rate. In the EKG; atrial flutter waves are observed as sawtooth-like atrial activity. Pathophysiologically, atrial flutter is a form of atrial reentry in which there is a premature electrical impulse creates a self-propagating circuit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004752 ; owl:annotatedTarget "A form of atrioventricular (AV) dissociation (i.e., the atria and the ventricles are under the control of two separate pacemakers) with congenital onset." . [] oboInOwl:hasDbXref , "PMID:12860883" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004754 ; owl:annotatedTarget "Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004755 ; owl:annotatedTarget "Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004755 ; owl:annotatedTarget "SVT" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "Elemental sulfur" . [] oboInOwl:hasDbXref , "PMID:30571060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004757 ; owl:annotatedTarget "Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004757 ; owl:annotatedTarget "Atrial fibrillation, paroxysmal" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004757 ; owl:annotatedTarget "Paroxysmal AF" . [] oboInOwl:hasDbXref "PMID:15913575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004758 ; owl:annotatedTarget "Polymorphic ventricular arrhythmias of varying morphologythat do not exist under resting conditions but appear only upon physical exercise or catecholamine administration." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "S" . [] oboInOwl:hasDbXref "MP:0010422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004762 ; owl:annotatedTarget "Underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004762 ; owl:annotatedTarget "Heart right ventricle hypoplasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004762 ; owl:annotatedTarget "Small right heart chamber" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004762 ; owl:annotatedTarget "Underdeveloped right heart chamber" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "S" . [] oboInOwl:hasDbXref "PMID:18025404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004763 ; owl:annotatedTarget "An episodic form of supraventricular tachycardia with abrupt onset and termination." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004763 ; owl:annotatedTarget "Episodic rapid heart beat" . [] oboInOwl:hasDbXref , "PMID:21143934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004764 ; owl:annotatedTarget "Myxomatous mitral valve is defined as the presence of excess leaflet tissue and leaflet thickening greater than 5 mm, resulting in a prolapse greater than 2 mm into the left atrium on parasternal long axis view." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004768 ; owl:annotatedTarget "Decreased number of head hairs per unit area on the anterior region of the scalp." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004768 ; owl:annotatedTarget "Sparse scalp hair at front of head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004768 ; owl:annotatedTarget "Thin scalp hair at front of head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004771 ; owl:annotatedTarget "Premature graying of body hair" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004771 ; owl:annotatedTarget "Premature greying of body hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004779 ; owl:annotatedTarget "Fragile, easily breakable scalp hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004779 ; owl:annotatedTarget "Brittle scalp hair" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "Schwefel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004780 ; owl:annotatedTarget "Excessive, increased hair growth located in the elbow region." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004780 ; owl:annotatedTarget "Hairy elbow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004780 ; owl:annotatedTarget "Hairy elbow syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004780 ; owl:annotatedTarget "Hypertrichosis cubiti" . [] oboInOwl:hasDbXref "PMID:32005960" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004780 ; owl:annotatedTarget "Pilosity of elbow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004783 ; owl:annotatedTarget "Presence of multiple polyps in the duodenum." . [] oboInOwl:hasDbXref , "PMID:25022750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004784 ; owl:annotatedTarget "The presence of multiple juvenile polyps in the stomach and intestine. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands. Juvenile polyps are a specific type of hamartomatous polyps." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004784 ; owl:annotatedTarget "Juvenile GI polyposis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "azufre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004785 ; owl:annotatedTarget "An anatomical anomaly that results from an abnormal rotation of the gut as it returns to the abdominal cavity during embryogenesis." . [] oboInOwl:hasDbXref , "PMID:18825677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004787 ; owl:annotatedTarget "Acute hepatitis complicated by acute liver failure with hepatic encephalopathy occurring less than 8 weeks after the onset of jaundice." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "soufre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004788 ; owl:annotatedTarget "Fluid retention and edema in the intestine caused by a compromised lymphatic system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004789 ; owl:annotatedTarget "An inability to digest lactose." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004789 ; owl:annotatedTarget "Lactose intolerance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004789 ; owl:annotatedTarget "Milk intolerance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "sulfur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004790 ; owl:annotatedTarget "Underdevelopment of the small intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004790 ; owl:annotatedTarget "Underdeveloped small intestine" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "sulfur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004791 ; owl:annotatedTarget "Defect in the epithelium of the esophagus, essentially an open sore in the lining of the esophagus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004791 ; owl:annotatedTarget "Esophagus ulcer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "sulphur" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004791 ; owl:annotatedTarget "Oesophagus ulcer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004791 ; owl:annotatedTarget "Oesophagus ulceration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004792 ; owl:annotatedTarget "The presence of a fistula between the perineum and the rectum." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26833 ; owl:annotatedTarget "theion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004794 ; owl:annotatedTarget "A deviation from the normal rotation of the midgut during embryologic development with mislocalization of the small bowel." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004795 ; owl:annotatedTarget "Polyp-like protrusions which are histologically hamartomas located in the stomach." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004796 ; owl:annotatedTarget "GI obstruction" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004796 ; owl:annotatedTarget "Gastrointestinal obstruction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004796 ; owl:annotatedTarget "Obstruction in digestive tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004797 ; owl:annotatedTarget "The presence of multiple areas of atresia affecting the small intestine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Recurrent infection of the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Recurrent gastrointestinal infections" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Recurrent infection of the GI tract" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Recurrent infection of the gastrointestinal tract" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Gastrointestinal infections" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004798 ; owl:annotatedTarget "Gastrointestinal infections, recurrent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004802 ; owl:annotatedTarget "A form of hemolytic anemia that occurs in repeated episodes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26834 ; owl:annotatedTarget "sulfur-containing amino acids" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004802 ; owl:annotatedTarget "Episodic hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004804 ; owl:annotatedTarget "A form of hemolytic anemia with congenital onset." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004804 ; owl:annotatedTarget "Congenital haemolytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004804 ; owl:annotatedTarget "Congenital hemolytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004804 ; owl:annotatedTarget "Neonatal hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "A form of leukemia characterized by overproduction of an early myeloid cell." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "AML" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "Acute myeloblastic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "Acute myelocytic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "Acute myelogenous leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004808 ; owl:annotatedTarget "Acute myeloid leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004809 ; owl:annotatedTarget "Low platelet count associated with maternal platelet-specific alloantibodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004810 ; owl:annotatedTarget "A type of hypoplastic anemia with congenital onset." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26835 ; owl:annotatedTarget "sulfur molecular entity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004810 ; owl:annotatedTarget "Congenital dyserythropoietic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004810 ; owl:annotatedTarget "Congenital hypoplastic anaemia" . [] oboInOwl:hasDbXref "NCIT:C8644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004812 ; owl:annotatedTarget "A type of ALL characterized by elevated levels of B-cell lymphoblasts in the bone marrow and the blood." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004812 ; owl:annotatedTarget "B Acute Lymphoblastic Leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004812 ; owl:annotatedTarget "Pre-B-cell acute lymphoblastic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004813 ; owl:annotatedTarget "Sudden onset of thrombocytopenia (reduced platelet count) within 5-10 days of the transfusion of blood products. The clinical presentation is post-transfusion purpura (PTP), wigth severe thrmbocytopenia, epistaxis, and hemorrhages." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004814 ; owl:annotatedTarget "A kind of hemolytic anemia that is induced by the ingestion of fava beans." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004814 ; owl:annotatedTarget "Fava bean-induced hemolytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004814 ; owl:annotatedTarget "Hemolytic anaemia following ingestion of fava beans" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004817 ; owl:annotatedTarget "A form of hemolytic anemia that is triggered by ingestion of certain drugs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26835 ; owl:annotatedTarget "sulfur molecular entities" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004817 ; owl:annotatedTarget "Drug-sensitive hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004818 ; owl:annotatedTarget "Paroxysmal nocturnal haemoglobinuria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004819 ; owl:annotatedTarget "A type of hypoplastic anemia in which the erythrocytes have a normal cell volume (the mean corpuscular volume is within normal limits)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004819 ; owl:annotatedTarget "Normocytic hypoplastic anaemia" . [] oboInOwl:hasDbXref "NCIT:C7463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004820 ; owl:annotatedTarget "An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004820 ; owl:annotatedTarget "Acute myelomonocytic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004821 ; owl:annotatedTarget "An excessive division of the lobes of the nucleus of a neutrophil." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004821 ; owl:annotatedTarget "Hypersegmentation of neutrophil nuclei in peripheral blood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004823 ; owl:annotatedTarget "A type of poikilocytosis characterized by the presence in the blood of erythrocytes of varying sizes and abnormal shapes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004825 ; owl:annotatedTarget "An abnormal increase in the binding affinity of hemoglobin for oxygen." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004825 ; owl:annotatedTarget "Increased Hb O2 affinity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004825 ; owl:annotatedTarget "Increased Hb oxygen affinity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004825 ; owl:annotatedTarget "Increased haemoglobin O2 affinity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004825 ; owl:annotatedTarget "Increased hemoglobin O2 affinity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004826 ; owl:annotatedTarget "A type of megaloblastic anemia that does not improve upon administration of folate. Since vitamin B12 acts by promoting recycling of folate, administration of vitamin B12 also does not improve this type of anemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004826 ; owl:annotatedTarget "Folate-unresponsive megaloblastic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004828 ; owl:annotatedTarget "A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts." . [] a owl:Axiom ; rdfs:label "Refractory anemia with ringed sideroblasts" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0004828 ; owl:annotatedTarget "ICD-O:M9982/3" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004828 ; owl:annotatedTarget "Refractory anaemia with ringed sideroblasts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004831 ; owl:annotatedTarget "Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004835 ; owl:annotatedTarget "The presence of erythrocytes that are sphere-shaped and reduced in size." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004836 ; owl:annotatedTarget "A type of acute myeloid leukemia in which abnormal promyelocytes predominate." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004836 ; owl:annotatedTarget "Acute promyelocytic leukaemia" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "CAS:7664-93-9" . [] oboInOwl:hasDbXref , "PMID:16304353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004839 ; owl:annotatedTarget "A form of severe hemolytic anemia characterized by erythrocyte morphology reminiscent of that seen in patients after a thermal burn." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004840 ; owl:annotatedTarget "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004840 ; owl:annotatedTarget "Hypochromic microcytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004840 ; owl:annotatedTarget "Hypochromic, microcytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004841 ; owl:annotatedTarget "Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004844 ; owl:annotatedTarget "A type of hemolytic anemia in which the Coombs test is positive." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004844 ; owl:annotatedTarget "Coombs-positive hemolytic anaemia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_142767 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-yl" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "CAS:7664-93-9" . [] oboInOwl:hasDbXref "PMID:24904835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004845 ; owl:annotatedTarget "The accumulation of transformed primitive hematopoietic blast cells, which lose their ability of normal differentiation and proliferation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004845 ; owl:annotatedTarget "AML-M5" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004845 ; owl:annotatedTarget "AMoL" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004845 ; owl:annotatedTarget "Acute monoblastic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004845 ; owl:annotatedTarget "Acute monocytic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004846 ; owl:annotatedTarget "Bleeding that persists longer than the normal time following a surgical procedure." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "CAS:7664-93-9" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004846 ; owl:annotatedTarget "Excessive bleeding during surgery" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004846 ; owl:annotatedTarget "Prolonged bleeding after surgery" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004846 ; owl:annotatedTarget "Protracted bleeding after surgery" . [] oboInOwl:hasDbXref "PMID:21472706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004848 ; owl:annotatedTarget "A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004848 ; owl:annotatedTarget "Ph-positive acute lymphoblastic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004848 ; owl:annotatedTarget "Philadelphia-positive acute lymphoblastic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004850 ; owl:annotatedTarget "Repeated episodes of the formation of a blot clot in a deep vein." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004850 ; owl:annotatedTarget "Recurrent deep vein blood clot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004851 ; owl:annotatedTarget "A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of folate." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004851 ; owl:annotatedTarget "Folate-responsive megaloblastic anaemia" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Gmelin:2122" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:13568755" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004852 ; owl:annotatedTarget "Decreased alkaline phosphatase measured within leukocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004852 ; owl:annotatedTarget "Reduced leukocyte ALP" . [] oboInOwl:hasDbXref , "PMID:8384898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004854 ; owl:annotatedTarget "Reduced platelet count that occurs sporadically, i.e., it comes and goes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004855 ; owl:annotatedTarget "An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein S. Protein S is a cofactor of protein C." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004856 ; owl:annotatedTarget "A type of anemia characterized by an normal concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004856 ; owl:annotatedTarget "Normochromic microcytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004857 ; owl:annotatedTarget "A type of anemia characterized by abnormally large erythrocytes with abnormally high amounts of haemoglobin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:16122922" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004857 ; owl:annotatedTarget "Hyperchromic macrocytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004859 ; owl:annotatedTarget "Thrombocytopenia related to lack of or severe reduction in the count of megakaryocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004860 ; owl:annotatedTarget "A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of thiamine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004860 ; owl:annotatedTarget "Thiamine-responsive megaloblastic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004861 ; owl:annotatedTarget "Refractory macrocytic anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004863 ; owl:annotatedTarget "Compensated hemolytic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004864 ; owl:annotatedTarget "A type of sideroblastic anemia that is not responsive to treatment." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004864 ; owl:annotatedTarget "Refractory sideroblastic anaemia" . [] oboInOwl:hasDbXref , "PMID:11413156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004866 ; owl:annotatedTarget "Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:19397353" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004870 ; owl:annotatedTarget "An chronic form of hemolytic anemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004870 ; owl:annotatedTarget "Chronic hemolytic anaemia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22047659" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004871 ; owl:annotatedTarget "The presence of a fistula between the bowel and the perineum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22136045" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004872 ; owl:annotatedTarget "An abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004876 ; owl:annotatedTarget "Pneumothorax occurring neonatally without traumatic injury to the chest or lung." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004878 ; owl:annotatedTarget "Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22204399" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004878 ; owl:annotatedTarget "Muscle weakness between ribs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004879 ; owl:annotatedTarget "Episodic hyperventilation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004879 ; owl:annotatedTarget "Intermittent overbreathing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004881 ; owl:annotatedTarget "Episodic slow breathing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004881 ; owl:annotatedTarget "Episodic under breathing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004885 ; owl:annotatedTarget "Episodic difficulty breathing" . [] oboInOwl:hasDbXref , "PMID:18710593", "PMID:28620428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004887 ; owl:annotatedTarget "A state of respiratory distress that requires a life saving intervention in the form of gaining airway access and instituting positive pressure ventilation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22267186" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004890 ; owl:annotatedTarget "An abnormally elevated blood pressure in the circulation of the pulmonary artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004890 ; owl:annotatedTarget "increased pulmonary artery pressure" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22296037" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004897 ; owl:annotatedTarget "A form of lactic acidemia that occurs in relation to stress or infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004898 ; owl:annotatedTarget "A continuous form of lactic acidemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004900 ; owl:annotatedTarget "A severe form of lactic acidemia." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22364556" . [] oboInOwl:hasDbXref , "PMID:15308499" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004901 ; owl:annotatedTarget "A form of lactic acidemia that occurs following exercise or exertion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004901 ; owl:annotatedTarget "Exercise-induced lactic acidosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004902 ; owl:annotatedTarget "A form of lactic acidemia with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004904 ; owl:annotatedTarget "The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistence, and lack of evidence of autoimmune destruction of the beta cells." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004904 ; owl:annotatedTarget "MODY" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "PMID:22435616" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004905 ; owl:annotatedTarget "Vitamin A deficiency" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004910 ; owl:annotatedTarget "HCO3-wasting renal tubular acidosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004911 ; owl:annotatedTarget "Repeated transient episodes of metabolic acidosis, that is, of the buildup of acid or depletion of base due to accumulation of metabolic acids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004913 ; owl:annotatedTarget "An intermittent (discontinuous) form of lactic acidemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004914 ; owl:annotatedTarget "Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004914 ; owl:annotatedTarget "Recurrent low blood sugar in infant" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Reaxys:2037554" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004915 ; owl:annotatedTarget "An impairment of galactose metabolism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004915 ; owl:annotatedTarget "Impaired galactose metabolism" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004916 ; owl:annotatedTarget "Generalised distal tubular acidosis" . [] oboInOwl:hasDbXref "PMID:31418093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004918 ; owl:annotatedTarget "A form of metabolic acidosis with increased serum chloride levels." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Sulfuric acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "dihydrogen tetraoxosulfate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004921 ; owl:annotatedTarget "An abnormality of magnesium ion homeostasis." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004921 ; owl:annotatedTarget "Abnormal Mg concentration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "dihydroxidodioxidosulfur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004923 ; owl:annotatedTarget "An increased concentration of L-phenylalanine in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004924 ; owl:annotatedTarget "An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral administration of glucose." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "hydrogen tetraoxosulfate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004925 ; owl:annotatedTarget "A chronic form of lactic acidemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004927 ; owl:annotatedTarget "An abnormal widening of the diameter of the pulmonary artery." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "hydrogen tetraoxosulfate(VI)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004930 ; owl:annotatedTarget "Abnormality of the lung blood vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004931 ; owl:annotatedTarget "Arteriosclerosis (increased thickness, increased stiffness, loss of elasticity) of the small arteries of the brain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004931 ; owl:annotatedTarget "Hardened artery wall in small cerebral arteries" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004933 ; owl:annotatedTarget "A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "sulfuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004934 ; owl:annotatedTarget "Abnormal calcification of the vasculature." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "sulfuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004935 ; owl:annotatedTarget "A congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "tetraoxosulfuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004936 ; owl:annotatedTarget "Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004936 ; owl:annotatedTarget "Blood clot in vein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004937 ; owl:annotatedTarget "An aneurysm (severe localized balloon-like outward bulging) in the pulmonary artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004938 ; owl:annotatedTarget "Excessive bending, twisting, and winding of a cerebral artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004938 ; owl:annotatedTarget "Twisted cerebral arteries" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Acide sulfurique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004940 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts, affecting arteries distributed throughout the body." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004940 ; owl:annotatedTarget "Generalised arterial calcification" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004941 ; owl:annotatedTarget "Increased pressure in the pre-hepatic portal vein." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Acido sulfurico" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004942 ; owl:annotatedTarget "Bulge in wall of large artery that carries blood away from heart" . [] oboInOwl:hasDbXref "PMID:29040156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004943 ; owl:annotatedTarget "Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004943 ; owl:annotatedTarget "Accelerated plaque build-up in arteries" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Acidum sulfuricum" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "H2SO4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004944 ; owl:annotatedTarget "The presence of a localized dilatation or ballooning of a cerebral artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0004944 ; owl:annotatedTarget "Brain aneurysm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004945 ; owl:annotatedTarget "A separation (dissection) of the layers of the extracranial portion of the internal carotid artery wall." . [] oboInOwl:hasDbXref "https://www.mayoclinic.org/diseases-conditions/arteriovenous-fistula/symptoms-causes/syc-20369567" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004947 ; owl:annotatedTarget "An abnormal connection between an artery and vein." . [] oboInOwl:hasDbXref "PMID:22433458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004948 ; owl:annotatedTarget "Abnormal twisting of arteries or veins." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004948 ; owl:annotatedTarget "Twisted blood vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004950 ; owl:annotatedTarget "Peripheral artery disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004950 ; owl:annotatedTarget "Peripheral vascular disease" . [] oboInOwl:hasDbXref "PMID:27122941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004952 ; owl:annotatedTarget "A rare vascular anomaly with a direct communication between pulmonary artery and pulmonary vein without an intervening capillary bed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Abnormal tortuous (i.e., twisted) form of arteries affecting most or all arteries." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "Schwefelsaeureloesungen" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Generalised arterial tortuosity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Generalised twisted arteries" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Generalized twisted arteries" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Arterial tortuosity, general" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Arterial tortuosity, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0004955 ; owl:annotatedTarget "Arterial tortuosity, generalized" . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "[S(OH)2O2]" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "[SO2(OH)2]" . [] oboInOwl:hasDbXref , "PMID:17192541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004960 ; owl:annotatedTarget "A congenital defect with aplasia (absence) of one of the right or left pulmonary artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004960 ; owl:annotatedTarget "Absent lung artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004960 ; owl:annotatedTarget "Missing pulmonary artery" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:16549603", "PMID:18458183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004961 ; owl:annotatedTarget "An anomalous origin of the left pulmonary artery, such that it arises from the posterior aspect of the right pulmonary artery and passes between the trachea and esophagus to reach the left hilum." . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26836 ; owl:annotatedTarget "sulphuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004962 ; owl:annotatedTarget "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004963 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004964 ; owl:annotatedTarget "Increase in mass of the tunica media of the arteries in the pulmonary circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004966 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the tunica media of large (conduit) arteries." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004968 ; owl:annotatedTarget "Recurrent bleeding into the parenchyma of the brain." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004968 ; owl:annotatedTarget "Recurrent cerebral haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004968 ; owl:annotatedTarget "Recurrent hemorrhagic stroke" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004969 ; owl:annotatedTarget "Stenosis of a peripheral branch of the pulmonary artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004969 ; owl:annotatedTarget "Narrowing of peripheral lung artery" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26873 ; owl:annotatedTarget "Terpenoid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004970 ; owl:annotatedTarget "Bulging of wall of large artery located above heart" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26873 ; owl:annotatedTarget "terpenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004971 ; owl:annotatedTarget "Underdevelopment of the pulmonary artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004971 ; owl:annotatedTarget "Underdeveloped lung artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004971 ; owl:annotatedTarget "Underdeveloped pulmonary artery" . [] oboInOwl:hasDbXref "PMID:18451345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004972 ; owl:annotatedTarget "An abnormal increase in the average blood pressure in an individual during a single cardiac cycle." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26873 ; owl:annotatedTarget "terpenoide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004974 ; owl:annotatedTarget "Coarctation of the aorta is a narrowing or constriction of a segment of the abdominal aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004975 ; owl:annotatedTarget "Flaring of distal femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004975 ; owl:annotatedTarget "Erlenmeyer flask shaped thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26873 ; owl:annotatedTarget "terpenoides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004977 ; owl:annotatedTarget "Missing radius bone on both sides associated with congenital failure of development." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26878 ; owl:annotatedTarget "tertiary alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004979 ; owl:annotatedTarget "Abnormally increased density of metaphyseal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004979 ; owl:annotatedTarget "Increased bone density in wide portion of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004980 ; owl:annotatedTarget "Reduction in density of metaphyseal bony tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26878 ; owl:annotatedTarget "tertiary alcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004987 ; owl:annotatedTarget "Shortening of the middle parts of the leg in relation to the upper and terminal segments." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004991 ; owl:annotatedTarget "Disproportionate shortening of the proximal segment of the arm (i.e. the humerus)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0004993 ; owl:annotatedTarget "Reduced diameter of a long bone with a more pronounced reduction of the diameter of the diaphysis of the long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0004993 ; owl:annotatedTarget "Slender long bones with narrow shaft" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26907 ; owl:annotatedTarget "tetrahydrofolate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005001 ; owl:annotatedTarget "Patellar dislocation occurring repeated times." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26907 ; owl:annotatedTarget "tetrahydrofolates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005003 ; owl:annotatedTarget "Absence or underdevelopment of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005003 ; owl:annotatedTarget "Absent/small end part of innermost thighbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005003 ; owl:annotatedTarget "Absent/underdeveloped end part of innermost thighbone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "Gmelin:327908" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26907 ; owl:annotatedTarget "tetrahydrofolic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005004 ; owl:annotatedTarget "An abnormally flat form of the proximal epiphysis of the radius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005005 ; owl:annotatedTarget "Congenital onset bending or abnormal curvature of the femur that normalizes with age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005005 ; owl:annotatedTarget "Bowing of thighbone at birth, straightening with time" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26932 ; owl:annotatedTarget "tetrapyrrole" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005008 ; owl:annotatedTarget "Large joint dislocations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005009 ; owl:annotatedTarget "The humerus is shortened and displays flaring (widening) of the metaphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005009 ; owl:annotatedTarget "Dumbbell-shaped long bone in upper arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005011 ; owl:annotatedTarget "Shortening of the middle parts of the arm in relation to the upper and terminal segments." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26932 ; owl:annotatedTarget "tetrapyrroles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005013 ; owl:annotatedTarget "Abnormally developed (dysplastic) distal epiphysis of the radius." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005019 ; owl:annotatedTarget "Thickening of shaft or central part of long bones" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26932 ; owl:annotatedTarget "a tetrapyrrole" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005021 ; owl:annotatedTarget "Dislocated elbows on both sides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005025 ; owl:annotatedTarget "Underdevelopment of the distal portion of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005028 ; owl:annotatedTarget "Wide innermost wide portion of shankbone bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005028 ; owl:annotatedTarget "Wide innermost wide portion of shinbone bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005033 ; owl:annotatedTarget "Underdevelopment of the distal portion of the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005035 ; owl:annotatedTarget "Developmental hypoplasia (shortening) of all phalanges of the foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005035 ; owl:annotatedTarget "Short toe bones" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26935 ; owl:annotatedTarget "LIPID_MAPS_class:LMPR0107" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005036 ; owl:annotatedTarget "Underdevelopment of the ulna on only one side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005037 ; owl:annotatedTarget "An abnormal osseous union (fusion) between the proximal portions of the radius and the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005039 ; owl:annotatedTarget "Multiple exostoses originating in long bones." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26935 ; owl:annotatedTarget "tetraterpenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005041 ; owl:annotatedTarget "Irregular surface of the normally relatively smooth capital femoral epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005041 ; owl:annotatedTarget "Irregular end part of innermost thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005043 ; owl:annotatedTarget "Irregularity of the normally smooth surface of the metaphysis at the proximal end of the humerus (at the shoulder)." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26935 ; owl:annotatedTarget "C40 isoprenoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005045 ; owl:annotatedTarget "An elevation in bone density of the cortex of one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005048 ; owl:annotatedTarget "Fusion of wrist bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005050 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint in an anterolateral direction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26935 ; owl:annotatedTarget "tetraterpenoides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005054 ; owl:annotatedTarget "Bony outgrowths that extend laterally from the margin of the metaphysis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005059 ; owl:annotatedTarget "Joint pain/Joint inflammation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "CAS:7493-90-5" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005063 ; owl:annotatedTarget "Fragmented, irregular end part of bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005066 ; owl:annotatedTarget "Cone-shaped end part of long bone fused within their wide portion of wide bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "glutamate(1-)" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "Gmelin:82500" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005067 ; owl:annotatedTarget "Overgrowth of the proximal part of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005067 ; owl:annotatedTarget "Overgrowth of innermost part of calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005070 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint in an proximal direction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "PMID:20717558" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005072 ; owl:annotatedTarget "The ability of the wrist joints to move beyond their normal range of motion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005072 ; owl:annotatedTarget "Increased wrist mobility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005084 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint in an anterior direction." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "rel-(2R,3R)-butane-1,2,3,4-tetrol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005085 ; owl:annotatedTarget "A limited ability of the knee joint to perform extension and flexion." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "(R*,R*)-1,2,3,4-butanetetrol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005089 ; owl:annotatedTarget "An abnormality of the pattern of trabecula (small interconnecting rods of bone) in a metaphyseal region of bone." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26981 ; owl:annotatedTarget "threo-tetritol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005090 ; owl:annotatedTarget "A lateral bending or abnormal curvature of the femur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005092 ; owl:annotatedTarget "The presence of streaks (bands) of abnormally increased density of metaphyseal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005092 ; owl:annotatedTarget "Streak increase in bone density in wide portion of wide bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005093 ; owl:annotatedTarget "Absence of the proximal radial epiphysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005096 ; owl:annotatedTarget "A bending or abnormal curvature of the distal portion of the femur." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005100 ; owl:annotatedTarget "Premature birth following premature rupture of foetal membranes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005101 ; owl:annotatedTarget "A type of hearing impairment affecting primarily the higher frequencies of sound (3,000 to 6,000 Hz)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005101 ; owl:annotatedTarget "Hearing loss, high-frequency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005101 ; owl:annotatedTarget "High frequency hearing loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005101 ; owl:annotatedTarget "Progressive high frequency hearing loss" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005102 ; owl:annotatedTarget "Deterioration or loss of the tissues of the cochlea." . [] oboInOwl:hasDbXref , "PMID:15523361", "PMID:23259082" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005103 ; owl:annotatedTarget "Ossification affecting the external ear cartilage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Underdevelopment of the nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Decreased size of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Decreased size of septum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Hypoplasia of septum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Small nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005104 ; owl:annotatedTarget "Small septum of nose" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "Beilstein:8204750" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005105 ; owl:annotatedTarget "Abnormal nose morphology" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005105 ; owl:annotatedTarget "Abnormal of morphology of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005105 ; owl:annotatedTarget "Abnormal of nasal shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005105 ; owl:annotatedTarget "Abnormal of shape of nose" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "hydrogen glutamate" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "CAS:80-68-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005106 ; owl:annotatedTarget "Any abnormality of the vertebral end plates, which are the top and bottom portions of the vertebral bodies that interface with the vertebral discs." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "CAS:80-68-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005107 ; owl:annotatedTarget "An abnormality of the sacral bone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "PMID:11379295" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005108 ; owl:annotatedTarget "Any structural abnormality of the intervertebral disk." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005108 ; owl:annotatedTarget "Abnormality of the intervertebral disc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005109 ; owl:annotatedTarget "An abnormality of the Achilles tendon." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "PMID:15221503" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005109 ; owl:annotatedTarget "Abnormality of the Achilles tendon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005110 ; owl:annotatedTarget "An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005110 ; owl:annotatedTarget "Quivering upper heart chambers resulting in irregular heartbeat" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "threonine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005115 ; owl:annotatedTarget "A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005115 ; owl:annotatedTarget "Supraventricular arrhythmias" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005116 ; owl:annotatedTarget "Abnormal tortuous (i.e., twisted) form of arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005117 ; owl:annotatedTarget "Abnormal increase in diastolic blood pressure." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005117 ; owl:annotatedTarget "Elevated diastolic BP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_26986 ; owl:annotatedTarget "Threonin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005120 ; owl:annotatedTarget "Any structural abnormality of a cardiac atrium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005120 ; owl:annotatedTarget "Abnormality of heart atrium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005121 ; owl:annotatedTarget "An excessive concavity of the posterior surface of one or more vertebral bodies." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27026 ; owl:annotatedTarget "toxin" . [] oboInOwl:hasDbXref "PMID:14966039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005132 ; owl:annotatedTarget "Compression of the heart caused by rigid, thickened, or fused pericardial membranes." . [] oboInOwl:hasDbXref , "PMID:17715105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005133 ; owl:annotatedTarget "Enlargement of the chamber of the right ventricle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27026 ; owl:annotatedTarget "toxins" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005134 ; owl:annotatedTarget "Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005135 ; owl:annotatedTarget "An abnormality of the T wave on the electrocardiogram, which mainly represents the repolarization of the ventricles." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27027 ; owl:annotatedTarget "micronutrients" . [] oboInOwl:hasDbXref , "PMID:23587525" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005136 ; owl:annotatedTarget "Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005143 ; owl:annotatedTarget "The right pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery." . [] oboInOwl:hasDbXref "PMID:21349577", "http://www.heart.org/HEARTORG/Conditions/More/Cardiomyopathy/Hypertrophic-Cardiomyopathy_UCM_444317_Article.jsp#.WmePRJM-dL4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005144 ; owl:annotatedTarget "The dividing wall between left and right sides of the heart, thickens and bulges into the left ventricle." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "2-ammoniopentanedioate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27027 ; owl:annotatedTarget "trace elements" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005145 ; owl:annotatedTarget "Narrowing of coronary artery" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "transition element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005146 ; owl:annotatedTarget "Abnormal calcification of a cardiac valve." . [] oboInOwl:hasDbXref "PMID:15372490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005150 ; owl:annotatedTarget "An impairment of the electrical continuity between the atria and ventricles." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005151 ; owl:annotatedTarget "Narrowing or constriction of the aorta localized proximal to the ductus arteriosus, i.e., to the preductal region of aortic arch." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "Uebergangselement" . [] oboInOwl:hasDbXref "PMID:21585276", "PMID:28050600" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005152 ; owl:annotatedTarget "A type of cardiomyopathy characterized pathologically by hamartomatous lesions of cardiac Purkinje cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "Uebergangsmetalle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005157 ; owl:annotatedTarget "Hypertrophic cardiomyopathy with an symmetrical and concentric pattern of hypertrophy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005160 ; owl:annotatedTarget "Total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium." . [] oboInOwl:hasDbXref "PMID:10956313", "http://www.heart.org/HEARTORG/Conditions/HeartFailure/AboutHeartFailure/Types-of-Heart-Failure_UCM_306323_Article.jsp#.WmeKyJM-dL4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005162 ; owl:annotatedTarget "Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "metal de transicion" . [] oboInOwl:hasDbXref "PMID:7704986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005164 ; owl:annotatedTarget "A congenital malformation of the pulmonary valve characterized by leaflet deformation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005165 ; owl:annotatedTarget "Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long." . [] oboInOwl:hasDbXref "PMID:25211049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005168 ; owl:annotatedTarget "An abnormal increase in magnitude of the pressure in the right atrium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005172 ; owl:annotatedTarget "Conduction block in the posterior division of the left bundle branch of the bundle of His." . [] oboInOwl:hasDbXref , "PMID:5817839" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005174 ; owl:annotatedTarget "Subvalvular stenosis is caused by a diaphragm-like membrane. The stenosis is clinically manifested like any other form of aortic stenosis but is often associated with some aortic insufficiency." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "metal de transition" . [] oboInOwl:hasDbXref "PMID:21349746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005176 ; owl:annotatedTarget "A congenital malformation of the aortic valve characterized by leaflet deformation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005177 ; owl:annotatedTarget "Arteriosclerosis occurring at an age that is younger than usual." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005177 ; owl:annotatedTarget "Premature hardening of arteries" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "metales de transicion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005180 ; owl:annotatedTarget "Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005180 ; owl:annotatedTarget "Tricuspid valve regurgitation" . [] oboInOwl:hasDbXref "PMID:28070240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005181 ; owl:annotatedTarget "Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005181 ; owl:annotatedTarget "Premature coronary artery disease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "metaux de transition" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005182 ; owl:annotatedTarget "The presence of a bicuspid pulmonary valve." . [] oboInOwl:hasDbXref "PMID:18391124" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005183 ; owl:annotatedTarget "An abnormal dilatation of lymph vessels in the pericardium." . [] oboInOwl:hasDbXref "PMID:24097136" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005184 ; owl:annotatedTarget "A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations." . [] oboInOwl:hasDbXref "PMID:24173273", "PMID:7713107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005185 ; owl:annotatedTarget "A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "transition element" . [] oboInOwl:hasDbXref "PMID:27412524", "PMID:30618151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005186 ; owl:annotatedTarget "Synovial hyperplasia involves proliferation of mesenchymal stromal/stem cells and leads to synovial thickening, which can be observed radiographically." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005191 ; owl:annotatedTarget "Dislocated knee since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005194 ; owl:annotatedTarget "Abnormally flat shape of the heads of the metatarsal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005194 ; owl:annotatedTarget "Flattened head of long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005197 ; owl:annotatedTarget "A sensation of stiffness in the joints that occurs following waking up in the morning." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "transition elements" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005197 ; owl:annotatedTarget "Generalised morning stiffness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005198 ; owl:annotatedTarget "Interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005198 ; owl:annotatedTarget "Stiff hinge joints" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "glutamate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "transition metal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005199 ; owl:annotatedTarget "Absence of the abdominal musculature." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27081 ; owl:annotatedTarget "transition metals" . [] oboInOwl:hasDbXref "PMID:23652324" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005202 ; owl:annotatedTarget "A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005203 ; owl:annotatedTarget "The occurrence of the full-thickness tear (perforation) of the wall of the esophagus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005206 ; owl:annotatedTarget "Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27092 ; owl:annotatedTarget "tricarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005207 ; owl:annotatedTarget "Hypertrophy of the stomach." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005207 ; owl:annotatedTarget "Increased stomach size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005208 ; owl:annotatedTarget "Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005208 ; owl:annotatedTarget "Secretory diarrhoea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27092 ; owl:annotatedTarget "tricarboxylates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005209 ; owl:annotatedTarget "The presence of cyst of the intrahepatic bile duct." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27092 ; owl:annotatedTarget "tricarboxylic acid trianions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005210 ; owl:annotatedTarget "Underdevelopment of the colon." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005210 ; owl:annotatedTarget "Underdeveloped colon" . [] oboInOwl:hasDbXref , "PMID:13316552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005212 ; owl:annotatedTarget "Leukoplakia is a precancerous dermatosis of mucous membranes analogous Leukoplakia is basically a chronic inflammatory hypertrophy in which anaplasia and malignant dyskeratosis may develop and subsequently advance to an invasive squamous cell cancer. The clinical diagnosis of primary anal leukoplakia is indicated by single or multiple slightly raised,irregular, marginated, grayish-white keratinized' patches in the anal canal. Tissue biopsy is necessary for confirmation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27093 ; owl:annotatedTarget "Tricarbonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005213 ; owl:annotatedTarget "The presence of abnormal calcium deposition lesions in the pancreas." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005213 ; owl:annotatedTarget "Pancreatic calcifications" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27093 ; owl:annotatedTarget "Trikarbonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005214 ; owl:annotatedTarget "Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005214 ; owl:annotatedTarget "Bowel obstruction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005214 ; owl:annotatedTarget "Intestinal blockage" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005214 ; owl:annotatedTarget "Intestinal obstruction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005215 ; owl:annotatedTarget "Increased susceptibility to Giardia lamblia infection of the intestine, as manifested by a medical history of multiple episodes of Giardia lamblia intestinal infection." . [] oboInOwl:hasDbXref "PMID:23713640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005216 ; owl:annotatedTarget "An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005216 ; owl:annotatedTarget "Chewing difficulties" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005216 ; owl:annotatedTarget "Chewing difficulty" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005216 ; owl:annotatedTarget "Difficulty chewing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005218 ; owl:annotatedTarget "The presence of a fistula (abnormal tunnel) between the anal canal and the perineum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27093 ; owl:annotatedTarget "tricarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005219 ; owl:annotatedTarget "Absence of gastric intrinsic factor, which is normally produced by the parietal cells of the stomach, and is required for the absorption of vitamin B12." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27136 ; owl:annotatedTarget "triols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005222 ; owl:annotatedTarget "The presence of multiple diverticula of the intestine." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_14321 ; owl:annotatedTarget "glutamic acid monoanion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27150 ; owl:annotatedTarget "trisaccharides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27171 ; owl:annotatedTarget "heterobicyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005224 ; owl:annotatedTarget "A collection of pus in the area of the rectum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27171 ; owl:annotatedTarget "organic heterobicyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005225 ; owl:annotatedTarget "Accumulation of cell free, noninflammatony fluid within the wall of the intestinal tract producing uniform thickening of the mucosal folds." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005225 ; owl:annotatedTarget "Intestinal oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005227 ; owl:annotatedTarget "Presence of multiple adenomatous polyps in the colon." . [] a owl:Axiom ; rdfs:label "Adenomatous polyposis coli" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0005227 ; owl:annotatedTarget "MEDDRA:10056981" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27207 ; owl:annotatedTarget "univalent acyl group" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27207 ; owl:annotatedTarget "univalent carboacyl groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005230 ; owl:annotatedTarget "Obstruction affecting the biliary tree." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27207 ; owl:annotatedTarget "univalent carboxylic acyl groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005231 ; owl:annotatedTarget "A chronic form of gastritis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005232 ; owl:annotatedTarget "The presence of developmental dysplasia of the pancreas." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "LIPID_MAPS_class:LMFA0103" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005233 ; owl:annotatedTarget "The presence of a hypoplastic gallbladder." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "PMID:5322381" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005235 ; owl:annotatedTarget "A developmental defect resulting in abnormal closure, or atresia of the tubular structure of the jejunum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005236 ; owl:annotatedTarget "A form of chronic pancreatitis that is characterized by calcification." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "alkene acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005237 ; owl:annotatedTarget "The presence of degenerative changes of the liver." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "olefinic acid" . [] oboInOwl:hasDbXref , "PMID:596929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005241 ; owl:annotatedTarget "A congenital defect characterized by the lack of ganglion cells in the entire intestine, i.e., the aganglionic segment comprises the entire large and small bowel." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005242 ; owl:annotatedTarget "Atresia in the extrahepatic bile duct." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "unsaturated fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005243 ; owl:annotatedTarget "Failure to form of portions of the abdominal musculature." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27208 ; owl:annotatedTarget "unsaturated fatty acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005244 ; owl:annotatedTarget "Death of digestive organ tissue due to poor blood supply" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005244 ; owl:annotatedTarget "GI infarctions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005245 ; owl:annotatedTarget "Developmental hypoplasia of the intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005245 ; owl:annotatedTarget "Underdeveloped instestine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005246 ; owl:annotatedTarget "A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27216 ; owl:annotatedTarget "urate dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005247 ; owl:annotatedTarget "Underdevelopment of the abdominal musculature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005248 ; owl:annotatedTarget "Atresia in the intrahepatic bile duct." . [] oboInOwl:hasDbXref , "PMID:6981794" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005248 ; owl:annotatedTarget "Bile duct paucity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005254 ; owl:annotatedTarget "Small chest on one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005254 ; owl:annotatedTarget "Underdeveloped chest on one side" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005255 ; owl:annotatedTarget "Aplasia (congenital absence) of the pectoralis minor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005256 ; owl:annotatedTarget "Aplasia (congenital absence) of the pectoralis minor on only one side of the chest." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27226 ; owl:annotatedTarget "uric acids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005257 ; owl:annotatedTarget "Small chest" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005257 ; owl:annotatedTarget "Small thorax" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005258 ; owl:annotatedTarget "Small/absent pec muscle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005258 ; owl:annotatedTarget "Underdeveloped/absent pec muscle" . [] oboInOwl:hasDbXref "PMID:23289840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005259 ; owl:annotatedTarget "Increased range of shoulder movement related to aplasia or hypoplasia of the clavicles that results in the ability to approximate the shoulders in front of the chest." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_144637 ; owl:annotatedTarget "4-hydroxy-D-proline" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27247 ; owl:annotatedTarget "3-(1H-imidazol-4-yl)prop-2-enoate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005261 ; owl:annotatedTarget "Hemorrhage occurring within a joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005261 ; owl:annotatedTarget "Bleeding within a joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005261 ; owl:annotatedTarget "Hemarthrosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005261 ; owl:annotatedTarget "Spontaneous joint haemorrhage" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27247 ; owl:annotatedTarget "urocanate" . [] oboInOwl:hasDbXref "PMID:27412524" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005262 ; owl:annotatedTarget "Any structural anomaly of the synovium, which is a membrane that lines the cavity of synovial joints and consists of a lining layer of macrophage-like synoviocytes and fibroblast-like synoviocytes, as well as a sublining of connective tissue. Synovial cells are thought to contribute to joint homeostasis by secreting various factors such as hyaluronic acid and lubricin important for joint lubrication and function, as well as disposing of the waste products." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005263 ; owl:annotatedTarget "The presence of inflammation of the gastric mucous membrane." . [] a owl:Axiom ; rdfs:label "Gastritis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0005263 ; owl:annotatedTarget "MEDDRA:10017853" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005263 ; owl:annotatedTarget "Stomach inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005264 ; owl:annotatedTarget "An abnormality of the gallbladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005264 ; owl:annotatedTarget "Abnormality of the gallbladder" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005265 ; owl:annotatedTarget "An abnormality of the jejunum, i.e., of the middle section of the small intestine." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "Beilstein:8128219" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005266 ; owl:annotatedTarget "A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005268 ; owl:annotatedTarget "A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005268 ; owl:annotatedTarget "Early foetal demise" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Deep laugh lines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Deep nasolabial crease" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "CAS:104-98-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Deep nasolabial fold" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Deep nasolabial groove" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Deep smile lines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Prominent laugh lines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Prominent nasolabial groove" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005272 ; owl:annotatedTarget "Prominent smile lines" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "PMID:11669511" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005273 ; owl:annotatedTarget "Lack of the cartilage of the nasal septum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005273 ; owl:annotatedTarget "Absent nasal septal cartilage" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005273 ; owl:annotatedTarget "Absent nasal septum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005273 ; owl:annotatedTarget "Ageneis of nasal septal cartilage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005273 ; owl:annotatedTarget "Failure of development of nasal septal cartilage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "PMID:24397532" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Large nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Large tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Prominent nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Prominent tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Pronounced nasal tip" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_144637 ; owl:annotatedTarget "(2R)-4-hydroxypyrrolidine-2-carboxylic acid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "PMID:24627570" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Pronounced tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Bulbous tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Hyperplasia of nasal tip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Hyperplasia of tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Hypertrophy of nasal tip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005274 ; owl:annotatedTarget "Hypertrophy of tip of nose" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "Reaxys:8128219" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005275 ; owl:annotatedTarget "Cartilaginous nasal ossification" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "3-(1H-imidazol-4-yl)prop-2-enoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Decreased size of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Decreased size of tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Hypoplasia of tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Small nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Small tip of nose" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "3-(1H-imidazol-4-yl)-2-propenoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Underdevelopment of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Underdevelopment of tip of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Aplasia of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Deficient nasal tip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Hypotrophic nasal tip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005278 ; owl:annotatedTarget "Hypotrophic tip of nose" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27248 ; owl:annotatedTarget "3-imidazol-4-ylacrylic acid" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Posterior positioning of the nasal root in relation to the overall facial profile for age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Depressed bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Depressed nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Flat bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Flat nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Flat, nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Flattened nasal bridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Low nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Low nasal root" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Retruded bridge of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Retruded nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Concave bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Concave nasal bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005280 ; owl:annotatedTarget "Depressed nasal root/bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Decreased size of bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Decreased size of nasal bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Hypoplastic bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Small bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Small nasal bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Hypotrophic bridge of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005281 ; owl:annotatedTarget "Hypotrophic nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Absent bridge of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Absent nasal bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Agenesis of bridge of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Agenesis of nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Missing bridge of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005285 ; owl:annotatedTarget "Missing nasal bridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Abnormality of the nostril." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Abnormality of the nostrils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Anomaly of the nares" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Deformity of the nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Deformity of the nostrils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Malformation of the nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005288 ; owl:annotatedTarget "Malformation of the nostrils" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_144637 ; owl:annotatedTarget "4-OH-D-Pro" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "Beilstein:506689" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005289 ; owl:annotatedTarget "Anomaly of the nasolabial region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005289 ; owl:annotatedTarget "Deformity of the nasolabial region" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005289 ; owl:annotatedTarget "Malformation of the nasolabial region" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "CAS:516-06-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005290 ; owl:annotatedTarget "Decreased size of internal carotid artery" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005290 ; owl:annotatedTarget "Small internal carotid artery" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005290 ; owl:annotatedTarget "Aplasia of internal carotid artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005290 ; owl:annotatedTarget "Deficiency of internal carotid artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005290 ; owl:annotatedTarget "Hypotrophic internal carotid artery" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "CAS:516-06-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005293 ; owl:annotatedTarget "Poorly functioning veins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005294 ; owl:annotatedTarget "A separation (dissection) of the layers of an artery." . [] oboInOwl:hasDbXref , "PMID:17593995", "PMID:18651460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005295 ; owl:annotatedTarget "Pseudocoarctation is a congenital anomaly of kinking, or buckling, of the aorta without a pressure gradient across the lesion. It is characterized by elongation and kinking of the aorta at the level of the ligamentum arteriosum." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "CAS:516-06-3" . [] oboInOwl:hasDbXref "PMID:18847480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005301 ; owl:annotatedTarget "A rare congenital vascular anomaly that results when the left superior cardinal vein caudal to the innominate vein fails to regress." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005301 ; owl:annotatedTarget "PLSVC" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005302 ; owl:annotatedTarget "Abnormal tortuous (i.e., twisted) form of the carotid arteries." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "Gmelin:49877" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005303 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the arch of aorta." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005304 ; owl:annotatedTarget "Underdeveloped lung veins" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005305 ; owl:annotatedTarget "Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005305 ; owl:annotatedTarget "Blood clot in cerebral vein" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005306 ; owl:annotatedTarget "The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005306 ; owl:annotatedTarget "Capillary hemangiomata" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005306 ; owl:annotatedTarget "Strawberry birthmark" . [] oboInOwl:hasDbXref , "PMID:16088500" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005310 ; owl:annotatedTarget "A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "Reaxys:506689" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005311 ; owl:annotatedTarget "Absent lung vessels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005312 ; owl:annotatedTarget "Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries in the pulmonary circulation." . [] oboInOwl:hasDbXref "PMID:27939641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005313 ; owl:annotatedTarget "An arterial lesion that is characterized by either intimal fibroplasia, with neointimal lesions of cells and matrix deposition, or medial fibroplasia, in which there is loss of smooth muscle cells and increased deposition of collagen and proteoglycans in the medial layer." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005318 ; owl:annotatedTarget "Inflammation of the blood vessels within the brain." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "valine" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "2-amino-3-methylbutanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005320 ; owl:annotatedTarget "Lack of facial fat below the skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005321 ; owl:annotatedTarget "A type of craniofacial dysostosis associated with abnormalities of the external ears, mirognathia, macrostomia, coloboma of the lower eyelid, and cleft palate. This is a bundled term that is left in the HPO now for convenience with legacy annotations but should not be used for new annotations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005321 ; owl:annotatedTarget "Treacher Collins syndrome" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_144637 ; owl:annotatedTarget "4-hydroxy-D-Pro" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "DL-valine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Prominent nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Prominent septum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Low hanging nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Low hanging septum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Visible nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005322 ; owl:annotatedTarget "Visible septum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Unilateral overgrowth of facial tissues, including muscles, bones and skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Enlargement of half of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Facial hemihypertophy" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "Hval" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Hemifacial enlargement" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Hypertrophy of half of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Increase in size of half of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Overgrowth of half of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Facial hemihyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005323 ; owl:annotatedTarget "Friedreich's disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005324 ; owl:annotatedTarget "An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005324 ; owl:annotatedTarget "Disturbance of facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005325 ; owl:annotatedTarget "A pattern of hair growth in which there is hair extending from the temples to the lateral eyebrows." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "Valin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005326 ; owl:annotatedTarget "Underdevelopment of the philtrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005326 ; owl:annotatedTarget "Small philtrum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005327 ; owl:annotatedTarget "Loss of facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005328 ; owl:annotatedTarget "A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27266 ; owl:annotatedTarget "valina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005328 ; owl:annotatedTarget "Premature aged appearance" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005329 ; owl:annotatedTarget "Fixed facial expression" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005329 ; owl:annotatedTarget "Unchanging facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005332 ; owl:annotatedTarget "Recurrent partial dislocations of the mandible." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005335 ; owl:annotatedTarget "Sleepy facial expression" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005335 ; owl:annotatedTarget "Somnolent facial expression" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27300 ; owl:annotatedTarget "D vitamins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005336 ; owl:annotatedTarget "Darkening of the forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005338 ; owl:annotatedTarget "Decreased density/number and/or decreased diameter of lateral eyebrow hairs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005338 ; owl:annotatedTarget "Laterally sparse eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005338 ; owl:annotatedTarget "Limited hair on end of eyebrow" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27300 ; owl:annotatedTarget "vitamin D vitamer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005338 ; owl:annotatedTarget "Sparse lateral eyebrows" . [] oboInOwl:hasDbXref , "PMID:19388161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005339 ; owl:annotatedTarget "An abnormality of the complement system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005341 ; owl:annotatedTarget "Abnormal bladder function (increased urge or frequency of urination or urge incontinence) resulting from abnormal functioning of the autonomic nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27300 ; owl:annotatedTarget "vitamin D vitamers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005343 ; owl:annotatedTarget "Underdevelopment of the urinary bladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005343 ; owl:annotatedTarget "Underdeveloped bladder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27300 ; owl:annotatedTarget "vitamin Ds" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27300 ; owl:annotatedTarget "vitamins D" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005346 ; owl:annotatedTarget "Abnormal facial expression" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_145810 ; owl:annotatedTarget "PMID:12137720" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27311 ; owl:annotatedTarget "essential oil component" . [] oboInOwl:hasDbXref "PMID:25375853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005347 ; owl:annotatedTarget """Tracheal cartilaginous sleeve (TCS) is a rare congenital airway malformation in which distinct tracheal rings are replaced by a continuous cartilaginous segment. Vertically fused C- or O-shaped cartilaginous rings can extend from the subglottis to the carina or bronchus with little to no pars membranacea posteriorly. Comment:Tracheal cartilaginous sleeve has been associated with various craniosynostosis syndromes.""" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005348 ; owl:annotatedTarget "Inspiratory stridor is a high pitched sound upon inspiration that is generally related to laryngeal abnormalities." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27311 ; owl:annotatedTarget "essential oil components" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005349 ; owl:annotatedTarget "Hypoplasia of the epiglottis." . [] oboInOwl:hasDbXref "PMID:18755723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005352 ; owl:annotatedTarget "A primary immune deficiency that is characterized by defects or deficiencies of T-lymphocytes that causes specific susceptibility to intracellular micro-organisms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005352 ; owl:annotatedTarget "Severe T-cell immunodeficiency" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005353 ; owl:annotatedTarget "Susceptibility to herpesvirus" . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005356 ; owl:annotatedTarget "Concentration of the complement component factor I in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27311 ; owl:annotatedTarget "ethereal oil component" . [] oboInOwl:hasDbXref "GO:0030183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005357 ; owl:annotatedTarget "Reduced functionality of the process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27311 ; owl:annotatedTarget "ethereal oil components" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005359 ; owl:annotatedTarget "Absence of the thymus. This feature may be appreciated by the lack of a thymic shadow upon radiographic examination." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005359 ; owl:annotatedTarget "Absent thymus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005365 ; owl:annotatedTarget "A severe form of B lymphocytopenia in which the count of B cells is very low or absent." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27311 ; owl:annotatedTarget "volatile oil components" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005366 ; owl:annotatedTarget "Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005368 ; owl:annotatedTarget "An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system." . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005369 ; owl:annotatedTarget "Concentration of the complement component factor H in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27314 ; owl:annotatedTarget "wasserloesliche Vitamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005372 ; owl:annotatedTarget "An abnormality of the physiological functioning of B cells." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005372 ; owl:annotatedTarget "Abnormality of B cell physiology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005372 ; owl:annotatedTarget "Reduced B cell function" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27314 ; owl:annotatedTarget "water-soluble vitamin" . [] oboInOwl:hasDbXref "http://www.dictionary.com/browse/cellular-immunodeficiency" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005374 ; owl:annotatedTarget "An immunodeficiency characterized by defective cell-mediated immunity or humoral immunity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005376 ; owl:annotatedTarget "Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent episodes of infection by Haemophilus influenzae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005381 ; owl:annotatedTarget "Recurrent infections by Neisseria meningitidis (one of the most common causes of bacterial meningitis), which is also known as meningococcus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005381 ; owl:annotatedTarget "Increased susceptibility to neisseria meningitidis infections" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27314 ; owl:annotatedTarget "water-soluble vitamins" . [] oboInOwl:hasDbXref , "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005384 ; owl:annotatedTarget "A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005386 ; owl:annotatedTarget "Increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection." . [] oboInOwl:hasDbXref "PMID:23321211" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005387 ; owl:annotatedTarget "A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Alternative_complement_pathway" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005389 ; owl:annotatedTarget "An abnormal reduction in the components of the alternative complement pathway, such as the C3 protein or its cleavage products." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005390 ; owl:annotatedTarget "Increased susceptibility to opportunistic infections, as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27325 ; owl:annotatedTarget "xanthophylls" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005400 ; owl:annotatedTarget "An abnormal reduction of the cell motility of neutrophils." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005401 ; owl:annotatedTarget "An increased susceptibility to candida infections, as manifested by a history of recurrent episodes of candida infections." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27325 ; owl:annotatedTarget "xanthophylls" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005403 ; owl:annotatedTarget "An abnormally low count of T cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005403 ; owl:annotatedTarget "Decrease in T cell count" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005403 ; owl:annotatedTarget "Low T cell count" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005403 ; owl:annotatedTarget "Reduced number of T cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_145810 ; owl:annotatedTarget "PMID:19251032" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005404 ; owl:annotatedTarget "An abnormal increase from the normal count of B cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005406 ; owl:annotatedTarget "Increased susceptibility to bacterial infections of the skin, as manifested by recurrent episodes of infectious dermatitis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005406 ; owl:annotatedTarget "Recurrent bacterial skin infections" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "CAS:7440-66-6" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "CAS:7440-66-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005407 ; owl:annotatedTarget "A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005411 ; owl:annotatedTarget "Persistent overgrowth of Candida albicans in the gastrointestinal tract." . [] oboInOwl:hasDbXref "PMID:15663032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005413 ; owl:annotatedTarget "An abnormally increased level of circulating alpha-globulin. Alpha globulins are a group of serum proteins defined by their mobility on serum electrophoresis. The alpha1-protein fraction is comprised of alpha1-antitrypsin, thyroid-binding globulin, and transcortin. Ceruloplasmin, alpha2-macroglobulin, and haptoglobin contribute to the alpha2-protein band. The alpha2 component is increased as an acute-phase reactant." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "Gmelin:16321" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005415 ; owl:annotatedTarget "A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "zinc" . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005416 ; owl:annotatedTarget "Concentration of the complement component factor B in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "ISBN:0781735149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005419 ; owl:annotatedTarget "Decreased or impaired activation of T cells in response to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005420 ; owl:annotatedTarget "Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "30Zn" . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005421 ; owl:annotatedTarget "Concentration of the complement component C3 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:17100769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005424 ; owl:annotatedTarget "Absence of specific immunoglobulins directed against a specific antigen or microorganism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005425 ; owl:annotatedTarget "An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "Zink" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005425 ; owl:annotatedTarget "Recurrent sinus and lung infections" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005429 ; owl:annotatedTarget "Increased susceptibility to systemic pyogenic infections, as manifested by recurrent episodes of systemic pyogenic infections." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005430 ; owl:annotatedTarget "Recurrent infections by bacteria of the genus Neisseria, including N. meningitidis (one of the most common causes of bacterial meningitis)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005432 ; owl:annotatedTarget "At birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient newborn hypogammaglobulinemia." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "Zn" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005435 ; owl:annotatedTarget "Abnormally reduced ability of T cells to perform their functions in cell-mediated immunity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005435 ; owl:annotatedTarget "Impaired T cell function" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005435 ; owl:annotatedTarget "T-cell dysfunction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005437 ; owl:annotatedTarget "Recurrent infections at an early age with improvement in later childhood." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "Zn(II)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Hypoplasia of the maxillozygomatic complex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Decreased size of zygomaticomaxillary bone complex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Deficiency of zygomaticomaxillary bone complex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Hypoplasia of malar bone complex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Hypoplasia of zygomaticomaxillary complex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Underdevelopment of zygomaticomaxillary bone complex" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "Zn2+" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005439 ; owl:annotatedTarget "Decreased projection of zygomaticomaxillary bone complex" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_145810 ; owl:annotatedTarget "PMID:25848166" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "cinc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005441 ; owl:annotatedTarget "An increased density in the cranial sutures following obliteration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005442 ; owl:annotatedTarget "The presence of a coronal suture (the cranial suture that separates the frontal and parietal bones) that is not ossified but rather wide open at an age when it is normally closed." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "zinc" . [] oboInOwl:hasDbXref "PMID:28295149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005445 ; owl:annotatedTarget "Abnormal increased size of the posterior cranial fossa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005446 ; owl:annotatedTarget "Abnormally flat (obtuse) angle of the mandible. The angle of the mandibular, located at the junction between the body and the ramus of the mandible, is normally close to being a right angle. This terms describes an abnormal increase of this angle such that the mandible appears flatter than normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005446 ; owl:annotatedTarget "High mandibular plane angle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005446 ; owl:annotatedTarget "Steep mandibular plane angle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27363 ; owl:annotatedTarget "zincum" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "zwitterion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005450 ; owl:annotatedTarget "An increase in bone density affecting the calvaria (roof of the skull)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "zwitterions" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "compose zwitterionique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005453 ; owl:annotatedTarget "Aplasia or hypoplasia of the paranasal sinuses." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005456 ; owl:annotatedTarget "Lack (aplasia) of the ethmoidal sinus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005456 ; owl:annotatedTarget "Agenesis of ethmoid sinuses" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "compuestos zwitterionicos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005456 ; owl:annotatedTarget "Failure of development of ethmoid sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005456 ; owl:annotatedTarget "Missing ethmoid sinuses" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "zwitteriones" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Normally, the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior fontanelle closes by about the middle of the second year. This term refers to the situation in which the fontanelles close at an inappropriately early time point." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Early closure of the cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Premature closure of the cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Early closure of the fontanelles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Early closure of the bregma sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005458 ; owl:annotatedTarget "Premature closure of the bregma sutures" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27369 ; owl:annotatedTarget "zwitterionic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005462 ; owl:annotatedTarget "The presence of calcium deposition in the falx cerebri." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_145810 ; owl:annotatedTarget "PMID:5941964" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005464 ; owl:annotatedTarget "Abnormally increased density of craniofacial bone tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Enlargement of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Enlargement of facial skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Hypertrophy of facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Hypertrophy of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Enlargment of the facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Excessive growth of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Excessive growth of facial skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Hyperostosis of facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Hyperostosis of facial skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Hypertrophy of the facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Increase in size of the facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Overgrowth of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Overgrowth of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Overgrowth of the facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Increased ossification of facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005465 ; owl:annotatedTarget "Increased ossification of facial skeleton" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "Beilstein:1720958" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Underdevelopment of the frontal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Decreased size of bone of forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Small bone of forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Underdevelopment of bone of forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Hypotrophic frontal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Hypotrophic frontal bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005466 ; owl:annotatedTarget "Thin bone of forehead" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "Beilstein:1745458" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Reduced convexity of the occiput (posterior part of skull)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Flat back of skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Flat back of the head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Flat back of the skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Flat posterior head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005469 ; owl:annotatedTarget "Flat posterior cranium" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "CAS:10569-72-9" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "CAS:10569-72-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005473 ; owl:annotatedTarget "Bony fusion of malleus, incus, and stapes." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "CAS:144-90-1" . [] oboInOwl:hasDbXref , , , "PMID:31173381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005474 ; owl:annotatedTarget "Abnormal reduction in ossification of the calvaria (roof of the skull consisting of the frontal bone, parietal bones, temporal bones, and occipital bone)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005474 ; owl:annotatedTarget "Soft skullcap" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "CAS:144-90-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005476 ; owl:annotatedTarget "The presence of a sagittal suture (the cranial suture that separates the left and right parietal bones) that is not ossified but rather wide open at an age when it is normally closed." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "Gmelin:1520758" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005477 ; owl:annotatedTarget "Progressively increasing bone density of the skull base without significant changes in bony contour." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_145810 ; owl:annotatedTarget "PMID:6069707" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01100054" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005478 ; owl:annotatedTarget "Large frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005478 ; owl:annotatedTarget "Hyperplasia of frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005478 ; owl:annotatedTarget "Hypertrophy of frontal sinus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:11785300" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005478 ; owl:annotatedTarget "Increased size of frontal sinus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005478 ; owl:annotatedTarget "Increased volume of frontal sinus" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:14576092" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005479 ; owl:annotatedTarget "An abnormally decreased level of immunoglobulin E (IgE) in blood." . [] oboInOwl:hasDbXref "PMID:16424154" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0005482 ; owl:annotatedTarget "The alternative complement pathway is one of three complement pathways, which is an innate component of the immune system's natural defense against infections. The alternative complement pathway has three unique components, factor B, factor D, and properdin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:18299183" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005483 ; owl:annotatedTarget "An abnormality of the epiglottis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:18600547" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005484 ; owl:annotatedTarget "Head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005484 ; owl:annotatedTarget "Development of small head that was not present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005484 ; owl:annotatedTarget "Acquired microcephaly" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:19186330" . [] oboInOwl:hasDbXref , "PMID:12825844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "A fontanelle that is small for age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Little cranial sutures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Small cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Little fontanelle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Microfontanelle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Small soft spot" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:19735301" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005486 ; owl:annotatedTarget "Small bregma sutures" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005487 ; owl:annotatedTarget "Vertical bony ridge positioned in the midline of the forehead." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005487 ; owl:annotatedTarget "Prominent frontal ridge" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005487 ; owl:annotatedTarget "Prominent metopic suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005487 ; owl:annotatedTarget "Prominent frontal suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005487 ; owl:annotatedTarget "Ridging of frontal suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005490 ; owl:annotatedTarget "The postnatal development of an abnormally large skull (macrocephaly)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:2274753" . [] oboInOwl:hasDbXref , "PMID:11711818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005495 ; owl:annotatedTarget "The frontal suture divides the two halves of the frontal bone in infants and usually fuses by the age of six years. The suture runs from the bregma (the point on the skull at which the coronal suture is intersected perpendicularly by the sagittal suture) to the nasion or nasal root. This term applies if the suture is widely patent from bregma to nasal root." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005505 ; owl:annotatedTarget "Refractory anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005506 ; owl:annotatedTarget "A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate." . [] a owl:Axiom ; rdfs:label "chronic myeloid leukemia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0005506 ; owl:annotatedTarget "DOID:8552" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005506 ; owl:annotatedTarget "Chronic myelocytic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005506 ; owl:annotatedTarget "Chronic myelogenous leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005506 ; owl:annotatedTarget "Chronic myeloid leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005507 ; owl:annotatedTarget "Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005507 ; owl:annotatedTarget "Haemoglobin Barts" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:5776546" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005507 ; owl:annotatedTarget "Hb Barts" . [] oboInOwl:hasDbXref , "PMID:25815903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005508 ; owl:annotatedTarget "Presence of a monoclonal immunoglobulin M protein in the serum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146306 ; owl:annotatedTarget "partially defined glycan" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:639325" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005510 ; owl:annotatedTarget "A transient reduction in the number of erythroblasts in the circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005510 ; owl:annotatedTarget "Transient decrease in blood erythrocyte number" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005511 ; owl:annotatedTarget "Anemia characterized by abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005511 ; owl:annotatedTarget "Heinz body anaemia" . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Staphylococcus_aureus" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005512 ; owl:annotatedTarget "A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "PMID:8307374" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005513 ; owl:annotatedTarget "Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "Reaxys:1720958" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005517 ; owl:annotatedTarget "A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005518 ; owl:annotatedTarget "Larger than normal size of erythrocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005518 ; owl:annotatedTarget "Increased MCV" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005520 ; owl:annotatedTarget "A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced." . [] oboInOwl:hasDbXref , "PMID:10451465", "PMID:11816725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005521 ; owl:annotatedTarget "Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005522 ; owl:annotatedTarget "A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005522 ; owl:annotatedTarget "Pyridoxine-responsive sideroblastic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005523 ; owl:annotatedTarget "Lymphoproliferative disorders" . [] oboInOwl:hasDbXref "NCIT:C7539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005526 ; owl:annotatedTarget "A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005526 ; owl:annotatedTarget "Lymphoid leukaemia" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "3-amino-2-methylpropanoic acid" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005527 ; owl:annotatedTarget "Reduction in the amount of kininogen, which functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005528 ; owl:annotatedTarget "A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005528 ; owl:annotatedTarget "Bone marrow failure" . [] oboInOwl:hasDbXref , "PMID:9107085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005531 ; owl:annotatedTarget "A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005531 ; owl:annotatedTarget "Acute biphenotypic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005531 ; owl:annotatedTarget "Biphenotypic acute leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005531 ; owl:annotatedTarget "Myeloid/lymphoid leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005532 ; owl:annotatedTarget "Macrocytic dyserythropoietic anaemia" . [] oboInOwl:hasDbXref "PMID:22966823" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005534 ; owl:annotatedTarget "A unique clonal neoplastic disorder that is linked to trisomy 21, is restricted to neonatal period, and spontaneously regresses. It often has characteristics of megakaryocytic lineage and is associated with GATA1 mutations in myeloblasts." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005534 ; owl:annotatedTarget "TMD" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "3-aminoisobutyric acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005534 ; owl:annotatedTarget "Transient leukaemia of Down syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005535 ; owl:annotatedTarget "A form of hemolytic anemia that can be triggered by exertion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005537 ; owl:annotatedTarget "Average platelet volume below the lower limit of the normal reference interval." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "2-(aminomethyl)propionic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005537 ; owl:annotatedTarget "Small platelet size" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005537 ; owl:annotatedTarget "Small platelets" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005537 ; owl:annotatedTarget "Small platelets size" . [] oboInOwl:hasDbXref "ISBN:9780721600406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005539 ; owl:annotatedTarget "A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005540 ; owl:annotatedTarget "A form of poikilocytosis in which the abnormally shaped erythrocytes have notches that results in projections that look like horns." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005540 ; owl:annotatedTarget "RBC keratocytosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005541 ; owl:annotatedTarget "Congenital onset of a marked decrease in the number of granulocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005542 ; owl:annotatedTarget "An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005543 ; owl:annotatedTarget "An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005547 ; owl:annotatedTarget "Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "2-Methyl-beta-alanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005548 ; owl:annotatedTarget "A reduced count of megakaryocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005550 ; owl:annotatedTarget "A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005550 ; owl:annotatedTarget "Chronic lymphatic leukaemia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "3-Amino-2-methylpropanoate" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005550 ; owl:annotatedTarget "Chronic lymphocytic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005556 ; owl:annotatedTarget "The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a \"metopic suture\"." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "3-Aminoisobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "An abnormality of the zygomatic arch, also known as the cheek bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Abnormality of the malar arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Anomaly of the malar arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Anomaly of the zygomatic arch" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "3-Aminoisobutanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Deformity of the malar arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Deformity of the zygomatic arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Malformation of the malar arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005557 ; owl:annotatedTarget "Malformation of the zygomatic arch" . [] oboInOwl:hasDbXref "NCIT:C3483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005558 ; owl:annotatedTarget "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005558 ; owl:annotatedTarget "Chronic blood cancer" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005558 ; owl:annotatedTarget "Chronic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005560 ; owl:annotatedTarget "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005560 ; owl:annotatedTarget "Imbalanced Hb synthesis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005560 ; owl:annotatedTarget "Imbalanced haemoglobin synthesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146306 ; owl:annotatedTarget "partially defined glycans" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "BAIB" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005561 ; owl:annotatedTarget "An anomaly of the form or number of cells in the bone marrow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005561 ; owl:annotatedTarget "Bone marrow disease" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005562 ; owl:annotatedTarget "The presence of many cysts in the kidney." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "DL-beta-aminoisobutyric acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005562 ; owl:annotatedTarget "Multiple kidney cysts" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005563 ; owl:annotatedTarget "A reduction in the count of nephrons per kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005564 ; owl:annotatedTarget "A lack of differentiation between renal cortex and medulla on diagnostic imaging." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "alpha-Methyl-beta-alanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005565 ; owl:annotatedTarget "Reduced differentiation between renal cortex and medulla on diagnostic imaging." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005567 ; owl:annotatedTarget "High urine magnesium in the presence of hypomagnesemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005574 ; owl:annotatedTarget "A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption without bicarbonate loss." . [] oboInOwl:hasDbXref "PMID:19846853", "PMID:28416508" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005575 ; owl:annotatedTarget "A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease." . [] oboInOwl:hasDbXref , "PMID:19144691", "PMID:22449945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005576 ; owl:annotatedTarget "A progressive detrimental connective tissue deposition (fibrosis) on the kidney parenchyma involving the tubules and interstitial tissue of the kidney. Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IF/TA) as the final common pathway. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation). For new annotations it is preferable to annotate to the specific HPO terms for Renal interstitial lfibrosis and/or Renal tubular atrophy." . [] oboInOwl:hasDbXref "PMID:25820368" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005579 ; owl:annotatedTarget "Any impairment of reabsorption of chloride by the kidney in order to not lose too much chloride in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005579 ; owl:annotatedTarget "Impaired reabsorption of Cl" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005579 ; owl:annotatedTarget "Impaired reabsorption of Cl-" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "bAib" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005580 ; owl:annotatedTarget "A duplication of the renal pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005583 ; owl:annotatedTarget "DIsruption and breaking up of the basement membrane of the tubules of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005584 ; owl:annotatedTarget "A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005584 ; owl:annotatedTarget "Cancer starting in small tubes in kidneys" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27389 ; owl:annotatedTarget "beta-aminoisobutyric acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005585 ; owl:annotatedTarget "Spotty increased pigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005586 ; owl:annotatedTarget "Increased pigmentation in sun-exposed areas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005588 ; owl:annotatedTarget "A focal type of palmoplantar keratoderma in which only certain areas of the palms and soles are affected." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005590 ; owl:annotatedTarget "Patchy hypopigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005590 ; owl:annotatedTarget "Spotty decreased pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005592 ; owl:annotatedTarget "The presence of large spherical melanosomes (1 to 6 micrometer in diameter) in the cytoplasm of melanocytes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005595 ; owl:annotatedTarget "Generalised hyperkeratosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005595 ; owl:annotatedTarget "Hyperkeratosis, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005597 ; owl:annotatedTarget "Loss of all scalp hair with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005598 ; owl:annotatedTarget "Telangiectases (small dilated blood vessels) located near the surface of the skin in a butterfly midface distribution." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005599 ; owl:annotatedTarget "Loss of hair color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005599 ; owl:annotatedTarget "Loss of hair colour" . [] oboInOwl:hasDbXref , "PMID:21139903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005600 ; owl:annotatedTarget "The giant congenital nevus is greater than 8 cm in size, pigmented and often hairy. A giant congenital nevus is smaller in infants and children, but it usually continues to grow with the child." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005600 ; owl:annotatedTarget "Giant pigmented mole" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005605 ; owl:annotatedTarget "Large hypermelanotic macules with jagged borders." . [] oboInOwl:hasDbXref , "PMID:14571173", "PMID:16553121", "PMID:21170223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005608 ; owl:annotatedTarget "The presence of a bilobed gallbladder, related to a duplication of the gallbladder primordium." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005609 ; owl:annotatedTarget "Gallbladder dysfunction" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146306 ; owl:annotatedTarget "partially-defined glycans" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "AGR:IND606960789" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005613 ; owl:annotatedTarget "Absence or underdevelopment of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005613 ; owl:annotatedTarget "Absent/small thighbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005613 ; owl:annotatedTarget "Absent/underdeveloped thighbone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Beilstein:100781" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "CAS:59-30-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005616 ; owl:annotatedTarget "An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005616 ; owl:annotatedTarget "Advanced bone age" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005616 ; owl:annotatedTarget "Early bone maturation" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "CAS:59-30-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005619 ; owl:annotatedTarget "Hyperconvexity of the thoracolumbar spine producing a rounded or humped appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005620 ; owl:annotatedTarget "The ability of the interphalangeal joints to move beyond their normal range of motion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005620 ; owl:annotatedTarget "Increased mobility of hinge joints" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "CAS:59-30-3" . [] oboInOwl:hasDbXref "PMID:33247084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005621 ; owl:annotatedTarget "An anomalous trapezoidal appearance of a vertebral body. A trapezoid is a four-sided shape that has two sides that are parallel and two sides that are not parallel. In this case, the two lateral sides of the vertebra are parallel, and the top and the bottom are slanted with respect to each other such that the vertebra is shorter in the fron or back than on the other side." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005621 ; owl:annotatedTarget "Trapezoidal shaped vertebral bodies" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005621 ; owl:annotatedTarget "Trapezoidal vertebral bodies" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Drug_Central:1231" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005622 ; owl:annotatedTarget "Increased cross-section (diameter) of the long bones. Note that widening may primarily affect specific regions of long bones (e.g., diaphysis or metaphysis), but this should be coded separately." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005622 ; owl:annotatedTarget "Broad long bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005622 ; owl:annotatedTarget "Wide long bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:10138938" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005622 ; owl:annotatedTarget "Widened long bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:10897644" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005623 ; owl:annotatedTarget "Absent ossification of the calvaria (vault of the skull)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005623 ; owl:annotatedTarget "Absent bone maturation of skullcap" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:10958818" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005625 ; owl:annotatedTarget "Osteoporosis affecting predominantly the vertebrae." . [] oboInOwl:hasDbXref "PMID:5443339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005626 ; owl:annotatedTarget "Bony fusion of the posterior part of the L5 vertebral body with the sacrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005627 ; owl:annotatedTarget "This type of brachydactyly is characterized by short and broad terminal phalanges of the thumbs and big toes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:11261364" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005632 ; owl:annotatedTarget "Absent forearm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005632 ; owl:annotatedTarget "Absent forearms" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_146500 ; owl:annotatedTarget "2-acetamido-2-deoxy-3-O-D-galactopyranosyl-D-galactopyranose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:11451208" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005639 ; owl:annotatedTarget "The ability of the joints of the hand to move beyond their normal range of motion." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:11959400" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005643 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the third toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005643 ; owl:annotatedTarget "Short 3rd toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005643 ; owl:annotatedTarget "Short third toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:14387833" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005645 ; owl:annotatedTarget "The presence of abnormal calcium deposition of the intervertebral disk." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005645 ; owl:annotatedTarget "Intervertebral disc calcification" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005645 ; owl:annotatedTarget "Multiple intervertebral disc calcifications" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005648 ; owl:annotatedTarget "Underdevelopment of the ulna on both sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005650 ; owl:annotatedTarget "A soft tissue continuity in the anteroposterior axis between the second to the fifth fingers that extends distally to at least the level of the proximal interphalangeal joints." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15321809" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15523939" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005652 ; owl:annotatedTarget "Sclerosis (abnormal hardening) of cortical bone, characterized by increased radiodensity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005653 ; owl:annotatedTarget "Moderate osteoporosis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005653 ; owl:annotatedTarget "Moderate generalised osteoporosis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15754725" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005655 ; owl:annotatedTarget "Multiple exostoses originating in the fingers and toes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005656 ; owl:annotatedTarget "A foot deformity resulting due to an abnormality affecting the muscle and soft tissue. In contrast if the bones of the foot are affected the term structural foot deformity applies." . [] oboInOwl:hasDbXref "PMID:26668420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005661 ; owl:annotatedTarget "Osteomyelitis caused by infection with the bacteria, salmonella." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15797531" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005661 ; owl:annotatedTarget "Salmonella bone infection" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15797685" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005665 ; owl:annotatedTarget "Extreme thickening of the cortex of long bones." . [] oboInOwl:hasDbXref , "PMID:21543665", "PMID:22224150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005667 ; owl:annotatedTarget "Separation of the odontoid process from the body of the axis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005671 ; owl:annotatedTarget "Deposition of calcium salts on both sides of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005679 ; owl:annotatedTarget "An abnormality of the hand resulting from contracture of the palmar fascia with a fixed flexion deformity of the metacarpophalangeal (MCP) joints and the proximal interphalangeal (PIP) joints." . [] oboInOwl:hasDbXref "PMID:25349664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005680 ; owl:annotatedTarget "A tongue-like protusion from the anterior aspect of lumbar vertebral bodies." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005681 ; owl:annotatedTarget "Juvenile RA" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/subtalar_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005681 ; owl:annotatedTarget "Juvenile idiopathic arthritis" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/subtalar_joint" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005682 ; owl:annotatedTarget "Fusion of foot joint" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/subtalar_joint" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005682 ; owl:annotatedTarget "Fusion of the subtalar joint" . [] oboInOwl:hasDbXref , "PMID:8923935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005684 ; owl:annotatedTarget "An inherited primary limb malformation disorder characterized by congenital contractures of two or more different body areas and without primary neurologic and/or muscle disease that affects limb function." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15831910" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005686 ; owl:annotatedTarget "Patchy (irregular) increase in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005686 ; owl:annotatedTarget "Patchy increase of bone mineral density" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005686 ; owl:annotatedTarget "Uneven increase in bone density" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:15990733" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005687 ; owl:annotatedTarget "Deformed head of long bone in upper arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005692 ; owl:annotatedTarget "Increased mobility and flexibility in the joint due to the tension in tissues such as ligaments and muscles." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005692 ; owl:annotatedTarget "Joints move beyond expected range of motion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_146500 ; owl:annotatedTarget "Gal(?1-3)GalNAc" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:16093404" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005694 ; owl:annotatedTarget "Partial fusion of innermost row of wrist bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005696 ; owl:annotatedTarget "Supernumerary digits located at the ulnar side of the hand with a complete extra finger and extra metacarpal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005707 ; owl:annotatedTarget "A bilateral form of triphalangeal thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005709 ; owl:annotatedTarget "Webbed skin of 2nd-3rd toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:16277678" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005715 ; owl:annotatedTarget "Flattened end part of knee bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005716 ; owl:annotatedTarget "Lethal dwarfism identifiable at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005720 ; owl:annotatedTarget "Abnormal reduction in length of all metacarpal bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005722 ; owl:annotatedTarget "The ability of the thumb joints to move beyond their normal range of motion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005722 ; owl:annotatedTarget "Double jointed thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:16380297" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005725 ; owl:annotatedTarget "A form of triphalangeal thumb that cannot be placed opposite the fingers of the same hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005726 ; owl:annotatedTarget "Short thumbs with bulbous tips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005731 ; owl:annotatedTarget "An abnormal irregularity of cortical bone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:16871332" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005733 ; owl:annotatedTarget "An abnormal narrowing of the spinal canal related to a reduction in the interpedicular distance (i.e., the distance measured between the pedicles on frontal [coronal] imaging)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005736 ; owl:annotatedTarget "Underdevelopment (reduced size) of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005736 ; owl:annotatedTarget "Short shinbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:17784727" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005736 ; owl:annotatedTarget "Short skankbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005739 ; owl:annotatedTarget "Partial dislocation of the head of the radius in the posterior direction." . [] oboInOwl:hasDbXref , "PMID:29481348", "PMID:30020602" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005743 ; owl:annotatedTarget "Avascular necrosis of the proximal epiphysis of the femur occurring in growing children and caused by an interruption of the blood supply to the head of the femur close to the hip joint. The necrosis is characteristically associated with flattening of the femoral head, for which reason the term coxa plana has been used to refer to this feature in the medical literature." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:18788725" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:19121630" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005746 ; owl:annotatedTarget "An increase in bone density affecting the basicranium (base of the skull)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:19335717" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005756 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses during the neonatal period." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005756 ; owl:annotatedTarget "Speckled calcifications in bone end parts in neonates" . [] oboInOwl:hasDbXref , "PMID:10084535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005758 ; owl:annotatedTarget "Abnormal elevation of the floor of the posterior fossa including occipital condyles and foramen magnum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005759 ; owl:annotatedTarget "An abnormally small and flat configuration of the posterior cranial fossa." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:19355913" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005759 ; owl:annotatedTarget "Small and flat posterior fossa of skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005759 ; owl:annotatedTarget "Small and flat posterior skull bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005766 ; owl:annotatedTarget "Disproportionate shortening of the shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005766 ; owl:annotatedTarget "Disproportionate shortening of the shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005768 ; owl:annotatedTarget "A soft tissue continuity in the anteroposterior axis between the toes 2, 3, and 4." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005768 ; owl:annotatedTarget "Webbed 2nd, 3rd and 4th toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005768 ; owl:annotatedTarget "Webbed second, third and fourth toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:24650098" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005769 ; owl:annotatedTarget "Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005769 ; owl:annotatedTarget "Curvature of outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005769 ; owl:annotatedTarget "Curvature of outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005769 ; owl:annotatedTarget "Curvature of outermost bone of pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146500 ; owl:annotatedTarget "D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galacto-hexopyranose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:33624660" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005772 ; owl:annotatedTarget "Absence or underdevelopment of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005772 ; owl:annotatedTarget "Absent/small shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005772 ; owl:annotatedTarget "Absent/small shinbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005772 ; owl:annotatedTarget "Absent/underdeveloped shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005772 ; owl:annotatedTarget "Absent/underdeveloped shinbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:33965562" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005773 ; owl:annotatedTarget "Underdevelopment of both forearm bones, the ulna and the radius, resulting in a shortened forearm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005773 ; owl:annotatedTarget "Short forearm" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:33968971" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:34207319" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005780 ; owl:annotatedTarget "Absence of the distal interphalangeal flexion creases of the fourth finger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005787 ; owl:annotatedTarget "A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the lumbar spine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:34219855" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005789 ; owl:annotatedTarget "An abnormal increase of bone mineral density with generalized involvement of the skeleton." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005789 ; owl:annotatedTarget "Increased bone density in skeletal bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:7738698" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005789 ; owl:annotatedTarget "Generalised osteosclerosis" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Bilateral hypoplasia of condylar process of mandible" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Bilateral hypoplasia of mandibular condylar head" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:8235383" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Bilateral hypoplasia of mandibular condylar neck" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Decreased height of condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Decreased length of condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Short condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Short condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0005790 ; owl:annotatedTarget "Short condylar neck of mandible" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9040515" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005791 ; owl:annotatedTarget "Abnormal thickening of the cortex of the diaphyseal region of long bones." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9420019" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005792 ; owl:annotatedTarget "Underdevelopment of the humerus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005792 ; owl:annotatedTarget "Short humerus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005792 ; owl:annotatedTarget "Short long bone of upper arm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005792 ; owl:annotatedTarget "Short upper arms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005793 ; owl:annotatedTarget "Abnormally short distal phalanx of toe of all toes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9565830" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005793 ; owl:annotatedTarget "Shortening of all outermost bone of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005798 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint in an posterior direction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005807 ; owl:annotatedTarget "Aplasia (absence) of the distal phalanges." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146500 ; owl:annotatedTarget "N-[(3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9683174" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005807 ; owl:annotatedTarget "Absent outermost digital bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005815 ; owl:annotatedTarget "The presence of more than 12 rib pairs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005815 ; owl:annotatedTarget "Extra ribs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9781393" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005817 ; owl:annotatedTarget "Combined syndactyly and polydactyly of the foot on the lateral side (i.e., on the side of the little toe)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005819 ; owl:annotatedTarget "Short (hypoplastic) middle phalanx of finger, affecting one or more fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005819 ; owl:annotatedTarget "Short middle bone of finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9808640" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005824 ; owl:annotatedTarget "Bending or curvature of a second toe in the tibial direction (i.e., towards the big toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005824 ; owl:annotatedTarget "Curvature of 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PMID:9808641" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Reaxys:100781" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005830 ; owl:annotatedTarget "One or more bent (flexed) toe joints that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005832 ; owl:annotatedTarget "A type of dysharmonic skeletal maturation in which there is a delay in skeletal maturation whose degree differs markedly in different bones." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "(2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005844 ; owl:annotatedTarget "An abnormally round shape of the middle phalanx of the finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005844 ; owl:annotatedTarget "Rounded middle bone of finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005849 ; owl:annotatedTarget "Generalized deposition of calcium salts within the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005855 ; owl:annotatedTarget "The presence of bone fractures in the prenatal period that are diagnosed at birth or before." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005855 ; owl:annotatedTarget "Multiple fractures present at birth" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Acfol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005855 ; owl:annotatedTarget "Multiple fractures, present at birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005855 ; owl:annotatedTarget "Numerous multiple fractures present at birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005855 ; owl:annotatedTarget "Numerous multiple fractures that are present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005856 ; owl:annotatedTarget "A dislocation of the head of the radius from its socket in the elbow joint in an ulnar direction." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Folate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005863 ; owl:annotatedTarget "In type E brachydactyly, shortening of the fingers is mainly in the metacarpals and metatarsals." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005864 ; owl:annotatedTarget "A pathologic entity characterized by a developmental defect in a long bone leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or \"false joint\")." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005866 ; owl:annotatedTarget "A form of triphalangeal thumb that can be placed opposite the fingers of the same hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005867 ; owl:annotatedTarget "Fused 4th-5th long bones of hand" . [] oboInOwl:hasDbXref , "PMID:20661403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005868 ; owl:annotatedTarget "An enchondroma is a benign growth of cartilage that develops within the medullary cavity of bone. Enchondromatosis refers to the presence of multiple enchondromas, and this term refers to the presence of multiple enchondromas within the medulla of metaphyseal bone. Radiographically an enchondroma presents a an oval, linear, or pyramidal osteolytic (radiolucent) lesion with well defined margins." . [] oboInOwl:hasDbXref , "PMID:335375" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005871 ; owl:annotatedTarget "An abnormality of skeletal development characterized by a disturbance of the metaphysis and its histological structure with relatively normal epiphyses and vertebrae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005872 ; owl:annotatedTarget "Disproportionately short middle and distal phalanges compared to the hand/foot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005873 ; owl:annotatedTarget "Combined syndactyly and polydactyly of the great toe." . _:genid56189 oboInOwl:hasDbXref ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005873 ; owl:annotatedTarget "Polysyndactyly of big toe" ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0001558 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:UBERON_0001075 [ a owl:Restriction ; owl:onProperty obo:BFO_0000050 ; owl:someValuesFrom obo:UBERON_0006072 ] ) ] ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Folicet" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005876 ; owl:annotatedTarget "Progressively worsening joint contractures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005879 ; owl:annotatedTarget "Multiple bent (flexed) finger joints that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005880 ; owl:annotatedTarget "Fusion of a metacarpal bone with the proximal phalanx of the finger distal to it across the corresponding metacarpophalangeal joint." . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_146500 ; owl:annotatedTarget "WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a3-b1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "Folsaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005880 ; owl:annotatedTarget "Fused long bone of hand with innermost finger bone" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0005885 ; owl:annotatedTarget _:genid56189 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005885 ; owl:annotatedTarget "A lack of bone mineralization of one or more body of cervical vertebra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005886 ; owl:annotatedTarget "Absence of a digit or of one or more phalanges of a finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "N-pteroyl-L-glutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Bony overgrowth of the internal (endosteal) surface of the calvaria and the base of skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Enlargement of the inner surface of the skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Hypertrophy of the internal surface of the cranial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Increased ossification of the internal surface of the cranial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Overgrowth of the inside of the skull" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PGA" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Thick inner surface of the skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Thick internal surface of the cranial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Excessive growth of inner surface of the skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Hyperostosis of the internal surface of the cranial bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Hyperostosis of the internal surface of the cranial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005890 ; owl:annotatedTarget "Overgrowth of the inner surface of the skull bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005891 ; owl:annotatedTarget "Progressive bending or abnormal curvature of the forearm skeleton." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005892 ; owl:annotatedTarget "Fusion of innermost shinbone and calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005894 ; owl:annotatedTarget "Duplication of the metacarpal I bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005894 ; owl:annotatedTarget "Double 1st long bones of hand" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "PteGlu" . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "acide folique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005897 ; owl:annotatedTarget "Severe degree of osteoporosis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005897 ; owl:annotatedTarget "Severe generalised osteoporosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005897 ; owl:annotatedTarget "Severe, generalised osteoporosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005900 ; owl:annotatedTarget "Presence of an angular or V -shaped indentation on the ulnar side of the fifth metacarpal bone (i.e., on the sides towards the fifth finger)." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "acido folico" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005905 ; owl:annotatedTarget "The presence of an abnormal curvature of the cervical vertebral column." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005905 ; owl:annotatedTarget "Abnormal neck curve" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005906 ; owl:annotatedTarget "An abnormally reduced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005910 ; owl:annotatedTarget "Rhomboid or triangular shaped 5th (little) finger middle phalanx." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "acidum folicum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005912 ; owl:annotatedTarget "Atresia of the biliary tree." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "folic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005913 ; owl:annotatedTarget "Abnormality of end part of long bone of hand" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "pteroyl-L-glutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005914 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005914 ; owl:annotatedTarget "Absent/small long bones of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005914 ; owl:annotatedTarget "Absent/underdeveloped long bones of hand" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "pteroyl-L-monoglutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005916 ; owl:annotatedTarget "Any abnormal shape or structure of the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005916 ; owl:annotatedTarget "Abnormal shape of long bones of hand" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "pteroylglutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005917 ; owl:annotatedTarget "The presence of more than the normal number of metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005917 ; owl:annotatedTarget "Extra long bones of hand" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "pteroylmonoglutamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005918 ; owl:annotatedTarget "Abnormalities affecting the phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005918 ; owl:annotatedTarget "Abnormality of the finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005920 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the phalanges of the hand. Note that this includes the epiphysis of the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "vitamin B11" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005922 ; owl:annotatedTarget "Any structural anomaly of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005922 ; owl:annotatedTarget "Abnormal shape of hand" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "vitamin B9" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "vitamin Bc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005923 ; owl:annotatedTarget "Abnormality of the wide portion of the hand bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "vitamin Be" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005924 ; owl:annotatedTarget "Any abnormality of the epiphyses of the phalanges or metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005924 ; owl:annotatedTarget "Abnormality of the end part of the hand bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27470 ; owl:annotatedTarget "vitamin M" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005925 ; owl:annotatedTarget "Abnormalities of shaft of long bone of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005927 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of the bones of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005927 ; owl:annotatedTarget "Absent/small hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005927 ; owl:annotatedTarget "Absent/underdeveloped hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005928 ; owl:annotatedTarget "Bone fusion involving the calf bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005929 ; owl:annotatedTarget "Bone fusion involving the shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005930 ; owl:annotatedTarget "An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005930 ; owl:annotatedTarget "Abnormal shape of end part of bone" . [] oboInOwl:hasDbXref , "PMID:22528889" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005932 ; owl:annotatedTarget "An abnormality of corticomedullary differentiation (CMD) on diagnostic imaging such as magnetic resonance imaging, computer tomography, or sonography. CMD is a difference in the visualization of cortex and medulla." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "Beilstein:2068416" . [] oboInOwl:hasDbXref , "MP:0011050" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005938 ; owl:annotatedTarget "Abnormal arrangement of the structures of the motile cilium." . [] oboInOwl:hasDbXref , "PMID:14338290", "PMID:16728712", "PMID:16738196", "PMID:23728865", "PMID:25657025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005942 ; owl:annotatedTarget "Diffuse filling of the distal airsspaces of the lungs, the alveoli, with macrophages. Desquamative interstitial pneumonitis (DIP) is characterized additionally by thickend alveolar septa and by a sparse inflammatory infiltrate that often includes plasma cells and occasional eosinophils. The alveoli are lined by plump cuboidal pneumocytes. Lymphoid aggregates may be present." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005943 ; owl:annotatedTarget "Breathing cessation" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "CAS:144-68-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005944 ; owl:annotatedTarget "Bilateral lack of development of the lungs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005944 ; owl:annotatedTarget "Absent lungs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005945 ; owl:annotatedTarget "Blockage of the upper airway at the level of the larynx often accompanied by respiratory distress." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "CAS:144-68-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005947 ; owl:annotatedTarget "Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005947 ; owl:annotatedTarget "Decreased sensitivity to hypoxaemia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005947 ; owl:annotatedTarget "Decreased sensitivity to hypoxemia" . [] oboInOwl:hasDbXref "PMID:20028879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005948 ; owl:annotatedTarget "The presence of multiple lung cysts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005949 ; owl:annotatedTarget "Recurrent episodes of apnea occurring during infancy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005950 ; owl:annotatedTarget "A membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005950 ; owl:annotatedTarget "Laryngeal webs" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070261" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005956 ; owl:annotatedTarget "Abnormal shortening of the larynx in the anteroposterior (front to back) axis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "(3R,3'R)-beta,beta-carotene-3,3'-diol" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005959 ; owl:annotatedTarget "An impairment of gluconeogenesis." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "Zeaxanthin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005961 ; owl:annotatedTarget "A decreased concentration of arginine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005961 ; owl:annotatedTarget "Low blood arginine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005964 ; owl:annotatedTarget "Episodes of reduced body termperature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005964 ; owl:annotatedTarget "Intermittent abnormally low body temperature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005964 ; owl:annotatedTarget "Intermittent hypothermia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005968 ; owl:annotatedTarget "Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "(3R,3'R)-dihydroxy-beta,beta-carotene" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005968 ; owl:annotatedTarget "Temperature instability" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0005968 ; owl:annotatedTarget "Body temperature instability" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005972 ; owl:annotatedTarget "Acidosis because of respiratory retention of carbon dioxide." . [] oboInOwl:hasDbXref "PMID:24357350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005973 ; owl:annotatedTarget "Reduced intestinal absorption of fructose. Breath testing after ingestion of fructose has been widely adopted as a standard method of identifying fructose malabsorption and intolerance. A dose of 25 g of fructose dissolved in a 10% solution is generally accepted as the appropriate dose of fructose for clinical use of H2 and CH4 breath testing. High levels of hydrogen in exhaled breath subsequent hours indicate fructose intolerance. Presence of malabsorption and reproduction of symptoms during a breath test provides the best objective evidence and symptom correlation for fructose intolerance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005974 ; owl:annotatedTarget "Intermittent episodes of ketoacidosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005978 ; owl:annotatedTarget "A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005978 ; owl:annotatedTarget "NIDDM" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005978 ; owl:annotatedTarget "Noninsulin-dependent diabetes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005978 ; owl:annotatedTarget "Type 2 diabetes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005978 ; owl:annotatedTarget "Type II diabetes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "all-trans-beta-carotene-3,3'-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005982 ; owl:annotatedTarget "A reduction in phenylalanine 4-monooxygenase level." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005984 ; owl:annotatedTarget "An elevation of alpha-feto protein in the maternal serum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0005986 ; owl:annotatedTarget "Limited neck mobility" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "PMID:1557408" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "all-trans-zeaxanthin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005986 ; owl:annotatedTarget "Limitation of neck motion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005987 ; owl:annotatedTarget "Enlargement of the thyroid gland related to multiple nodules in the thyroid gland." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005987 ; owl:annotatedTarget "Multinodular goitre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005988 ; owl:annotatedTarget "A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "anchovyxanthin" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Excess skin around the neck, often lying in horizontal folds." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Excess neck skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Excess skin over the neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Redundant neck skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Redundant skin folds of neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005989 ; owl:annotatedTarget "Redundant skin over the neck" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27547 ; owl:annotatedTarget "beta,beta-carotene-3,3'-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005990 ; owl:annotatedTarget "Developmental hypoplasia of the thyroid gland." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005990 ; owl:annotatedTarget "Small thyroid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005991 ; owl:annotatedTarget "Limited cervical flexion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005991 ; owl:annotatedTarget "Limited neck flexibility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005994 ; owl:annotatedTarget "Enlargement of the thyroid gland related to one or more nodules in the thyroid gland." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005994 ; owl:annotatedTarget "Nodular goitre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005995 ; owl:annotatedTarget "Reduced amount of adipose tissue in the region of the neck." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005995 ; owl:annotatedTarget "Loss of fat around neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005997 ; owl:annotatedTarget "Restricted neck mobility due to contractures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0005997 ; owl:annotatedTarget "Restricted neck movement due to contractures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0005999 ; owl:annotatedTarget "A developmental defect defined by the failure of the formation of the lumen (tube) of the ureter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006000 ; owl:annotatedTarget "Obstruction of the flow of urine through the ureter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006006 ; owl:annotatedTarget "Degeneration of small hand muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006008 ; owl:annotatedTarget "Short digits on one side" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "Beilstein:84087" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006009 ; owl:annotatedTarget "Increased side-to-side width of one or more phalanges of the fingers or toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006009 ; owl:annotatedTarget "Wide digital bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006011 ; owl:annotatedTarget "Severely shortened metacarpal with a cuboidal appearance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006011 ; owl:annotatedTarget "Short, cube shaped long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006012 ; owl:annotatedTarget "Broad shaft of long bone of hand" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "CAS:4998-57-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006014 ; owl:annotatedTarget "Abnormally shaped wrist bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "Gmelin:3656" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006016 ; owl:annotatedTarget "Delay in the process of formation and maturation of the epiphysis of one or more phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006016 ; owl:annotatedTarget "Delayed bone maturation of end part of digital bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006019 ; owl:annotatedTarget "Decreased space in hinge joint" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "PMID:24629268" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006026 ; owl:annotatedTarget "Rounded end part of bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006028 ; owl:annotatedTarget "Metaphyseal cupping affecting the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006028 ; owl:annotatedTarget "Cupping of wide portion of long bone of hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006035 ; owl:annotatedTarget "Cone-shaped end part of digital bones 2 to 5" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "PMID:29286160" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006040 ; owl:annotatedTarget "Long 2nd long bone of hand" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "Reaxys:84087" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006042 ; owl:annotatedTarget "Y-shaped metacarpals are the result of a partial fusion of two metacarpal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metacarpals may be seen in combination with polydactyly." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006042 ; owl:annotatedTarget "Y-shaped long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006045 ; owl:annotatedTarget "Short pointed digital bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "2-amino-3-(1H-imidazol-4-yl)propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006048 ; owl:annotatedTarget "Abnormal increase in width of the distal region of the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006048 ; owl:annotatedTarget "Wide outermost end of long bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "Histidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006059 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the metacarpal bones, producing a 'ball-in-a-socket' appearance. This epiphyses are located at the distal ends of the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006059 ; owl:annotatedTarget "Cone-shaped end part of long bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006060 ; owl:annotatedTarget "Tombstone-shaped innermost digital bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006064 ; owl:annotatedTarget "Limited movement of hinge joints" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "histidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006067 ; owl:annotatedTarget "A delay in the process of formation and maturation of the epiphysis of one or more long bones." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006067 ; owl:annotatedTarget "Multiple carpal ossification centres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006070 ; owl:annotatedTarget "A chronic loss of joint motion in metacarpophalangeal joints due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "DL-Histidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006077 ; owl:annotatedTarget "Absence of the proximal interphalangeal flexion creases of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006089 ; owl:annotatedTarget "Excessive sweating of hands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006092 ; owl:annotatedTarget "Malalignement of carpal bone angles either with respect to each other, to the corresponding metacarpals or with respect to the wrist (radius and ulna)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006092 ; owl:annotatedTarget "Incorrect alignment of wrist bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "Histidin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006094 ; owl:annotatedTarget "Increased mobility in finger joint" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006095 ; owl:annotatedTarget "Wide tips of outermost digital bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "PMID:9007687" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "alpha-Amino-1H-imidazole-4-propionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006097 ; owl:annotatedTarget "Syndactyly with fusion of fingers three and four." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006097 ; owl:annotatedTarget "Webbed 3rd-4th fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006099 ; owl:annotatedTarget "Increased mobility of one ore more metacarpophalangeal joint." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27570 ; owl:annotatedTarget "histidina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006101 ; owl:annotatedTarget "Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as \"Symphalangism\"." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006107 ; owl:annotatedTarget "Telangiectasia (small dilated blood vessels) located in the fingerpads at the tips of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006107 ; owl:annotatedTarget "Small dilated blood vessels in fingerpads" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006108 ; owl:annotatedTarget "Metacarpal that becomes thinner toward the distal end." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006108 ; owl:annotatedTarget "Tapered long bones of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006109 ; owl:annotatedTarget "Absence of one or more interphalangeal creases (i.e., of the transverse lines in the skin between the phalanges of the fingers)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006110 ; owl:annotatedTarget "Short, hypoplastic middle phalanx of finger, affecting all fingers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006114 ; owl:annotatedTarget "The presence of multiple creases on the palm of the hand (more than the normal three major creases (distal transverse crease, proximal transverse crease, and thenar crease)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006114 ; owl:annotatedTarget "Multiple palm lines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006118 ; owl:annotatedTarget "Hypoplasia of all of the distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006118 ; owl:annotatedTarget "Shortening of all outermost bones of the fingers" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "Beilstein:3224996" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006119 ; owl:annotatedTarget "Some or all of the metacarpal bones (i.e., metacarpal II to V) have a pointed proximal appearance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006119 ; owl:annotatedTarget "Pointed innermost long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006119 ; owl:annotatedTarget "Pointed proximal metacarpals" . [] oboInOwl:hasDbXref "PMID:20862203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006121 ; owl:annotatedTarget "A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "CAS:52-39-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006127 ; owl:annotatedTarget "Increased length of the proximal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006127 ; owl:annotatedTarget "Long innermost finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006129 ; owl:annotatedTarget "Rounding and broadening of the tufts of the distal phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006129 ; owl:annotatedTarget "Drumstick shaped digital bones" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "CAS:52-39-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006134 ; owl:annotatedTarget "Abnormally large size of one or more growth plates (epiphyses) of the metacarpal bones (i.e., the tubular bones of the hand between the carpus and the phalanges)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006134 ; owl:annotatedTarget "Enlarged end part of long bone of hand" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006135 ; owl:annotatedTarget "Decreased finger mobility" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006135 ; owl:annotatedTarget "Decreased finger movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006140 ; owl:annotatedTarget "Fusion of the epiphysis and metaphysis of one or more phalanges prior to the normal age or stage of growth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006140 ; owl:annotatedTarget "Premature fusion of end part of digital bone" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006143 ; owl:annotatedTarget "Abnormal finger flexion creases" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006144 ; owl:annotatedTarget "Congenital hypoplasia of proximal phalanx of finger or all fingers." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "CAS:52-39-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006144 ; owl:annotatedTarget "Shortening of all innermost bones of the fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006145 ; owl:annotatedTarget "A central Y-shaped metacarpal is the result of a partial fusion of two central metacarpals (i.e., metacarpals 2-4) of the hand, with the two arms of the Y pointing in the distal direction. Central Y-shaped metacarpals may be seen as a result of a central polydactyly with partial fusion of the duplicated metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006145 ; owl:annotatedTarget "Y-shaped central long bones of hand" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "Drug_Central:111" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006146 ; owl:annotatedTarget "Increased side-to-side width of the metacarpal epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006146 ; owl:annotatedTarget "Broad end part of long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006150 ; owl:annotatedTarget "A swan neck deformity describes a finger with a hyperextended PIP joint and a flexed DIP joint. The most common cause for a swan neck-like deformity is a disruption of the end of the extensor tendon. Conditions that loosen the PIP joint and allow it to hyperextend, for example conditions that weaken the volar plate, can produce a swan neck deformity of the finger. One example is rheumatoid arthritis. Another cause are conditions that tighten up the small (intrinsic) muscles of the hand and fingers, for example hand trauma or nerve disorders, such as cerebral palsy, Parkinson's disease, or stroke." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "xanthine" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02030026" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006152 ; owl:annotatedTarget "The term proximal symphalangism refers to a bony fusion of the middle and proximal phalanges of the digits of the hand, in other words the proximal interphalangeal joint (PIJ) is missing which can be seen either on x-rays or as an absence of the proximal interphalangeal finger creases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006152 ; owl:annotatedTarget "Fused innermost hinge joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006153 ; owl:annotatedTarget "Disharmonious wrist bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "PMID:10438974" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006155 ; owl:annotatedTarget "Increased length of multiple or a single phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006155 ; owl:annotatedTarget "Long finger bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "Reaxys:3224996" . [] oboInOwl:hasDbXref , "PMID:10955488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006156 ; owl:annotatedTarget "Bending or curvature of a thumb towards the ulnar side (towards the ring finger)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006156 ; owl:annotatedTarget "Curved thumb deviated towards palm" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006157 ; owl:annotatedTarget "Prominent life line" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "ALDOSTERONE" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006159 ; owl:annotatedTarget "The presence of a supernumerary finger (not a thumb) involving the third or fourth metacarpal with associated osseous syndactyly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006160 ; owl:annotatedTarget "Irregular morphology of one or more metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006160 ; owl:annotatedTarget "Irregular long bones of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006161 ; owl:annotatedTarget "Short long bone of hand with rounded innermost ends" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006162 ; owl:annotatedTarget "Soft tissue swelling of hinge joints" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "Aldosterone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006165 ; owl:annotatedTarget "Proportionate shortening of all digits" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "aldosterone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006166 ; owl:annotatedTarget "Cylindrical shaped long bones of hand" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "(+)-aldosterone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006167 ; owl:annotatedTarget "Prominent innermost hinge joints" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006169 ; owl:annotatedTarget "Decreased mobility 3rd-5th fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006170 ; owl:annotatedTarget "A morphological abnormality of distal phalanges such that they have the appearance of chess pawns." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006170 ; owl:annotatedTarget "Chess-pawn shaped outermost bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006172 ; owl:annotatedTarget "Flattened, squared-off end part of tubular bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006174 ; owl:annotatedTarget "Increase in bone density in the diaphyseal (shaft) region of a metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006175 ; owl:annotatedTarget "Thickening of connective tissue of innermost finger bone" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "(11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006176 ; owl:annotatedTarget "Two carpal ossification centres present at birth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27584 ; owl:annotatedTarget "11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006179 ; owl:annotatedTarget "Extra bone on end of second long bone of hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "2,6-dioxopurine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006180 ; owl:annotatedTarget "Crowded wrist bones" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "CAS:7440-44-0" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006184 ; owl:annotatedTarget "Poorly defined or shallow palmar creases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006184 ; owl:annotatedTarget "Shallow palm line" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006184 ; owl:annotatedTarget "Shallow palmar creases" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "CAS:7440-44-0" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006185 ; owl:annotatedTarget "Enlarged innermost hinge joint" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "carbon" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006191 ; owl:annotatedTarget "Excessively deep creases of the palm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006191 ; owl:annotatedTarget "Deep palm line" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006192 ; owl:annotatedTarget "Phalanges of the fingers becoming thinner toward the distal end." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "6C" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006192 ; owl:annotatedTarget "Tapered finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006193 ; owl:annotatedTarget "The middle phalanx of finger resembles a thimble, a small metal cap to protect the finger while sewing that has a broad (proximal) base and narrower top, whereby both base and top are flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006193 ; owl:annotatedTarget "Thimble-shaped middle bones of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006200 ; owl:annotatedTarget "Widened outermost bone of limb" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "C" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006201 ; owl:annotatedTarget "Increased mobility of outermost hinge joint" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "C" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006203 ; owl:annotatedTarget "Decreased range of movement range in hinge joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006205 ; owl:annotatedTarget "Alteration of the normally smooth radiographic contour of phalanges producing an irregular appearance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006205 ; owl:annotatedTarget "Irregular finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006206 ; owl:annotatedTarget "Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the second finger." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "Carbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006208 ; owl:annotatedTarget "Metaphyseal cupping affecting the proximal phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006209 ; owl:annotatedTarget "Partial-complete absence of 5th digital bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006213 ; owl:annotatedTarget "Thin innermost bone with broad end part of the hand bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006216 ; owl:annotatedTarget "Presence of only one (instead of two, as normal) interphalangeal crease of the fifth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006217 ; owl:annotatedTarget "Limited mobility of innermost hinge joint" . [] oboInOwl:hasDbXref , "PMID:10662807" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006224 ; owl:annotatedTarget "A reduction in diameter of the distal phalanx of finger towards the distal end such that the tip of the phalanx comes to a point (this feature can be observed on radiograms)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "Kohlenstoff" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006234 ; owl:annotatedTarget "An increased resorption of bone matrix by osteoclasts leading to bony defects involving the tarsal bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "carbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006236 ; owl:annotatedTarget "Decreased width of the metacarpal bones (that is, reduced diameter)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006236 ; owl:annotatedTarget "Slender long bones of hand" . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002131 ; owl:annotatedTarget (obo:BFO_0000051 obo:BFO_0000050 ) . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "2,6-dioxopurines" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "carbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006237 ; owl:annotatedTarget "Prominent hinge joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006239 ; owl:annotatedTarget "Abnormal shortening of all middle phalanges of toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006239 ; owl:annotatedTarget "Shortening of all the middle bones of the toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "carbonium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006247 ; owl:annotatedTarget "Enlarged hinge joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006248 ; owl:annotatedTarget "An abnormal limitation of the mobility of the wrist." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006248 ; owl:annotatedTarget "Limited movement of the wrist" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006248 ; owl:annotatedTarget "Limited wrist movement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27594 ; owl:annotatedTarget "carbono" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006253 ; owl:annotatedTarget "Swelling of innermost hinge joints" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "Beilstein:110598" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006254 ; owl:annotatedTarget "Concentration of alpha-fetoprotein in the blood circulation above the upper limit of normal." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "CAS:461-72-3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006256 ; owl:annotatedTarget "Abnormality of hand joint mobility" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "CAS:461-72-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006257 ; owl:annotatedTarget "Abnormal wrist bone maturation" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "CAS:461-72-3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006261 ; owl:annotatedTarget "Abnormality of the small joints of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "A small/hypoplastic or absent/aplastic 5th finger." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "Gmelin:101266" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/small little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/small pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/small pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/underdeveloped little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/underdeveloped pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006262 ; owl:annotatedTarget "Absent/underdeveloped pinky finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "Hydantoin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006263 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006263 ; owl:annotatedTarget "Abnormality of the end part of the index finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "imidazolidine-2,4-dione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006264 ; owl:annotatedTarget "A small/hypoplastic or absent/aplastic 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006264 ; owl:annotatedTarget "Absent/small index finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006264 ; owl:annotatedTarget "Absent/underdeveloped index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15318 ; owl:annotatedTarget "xanthines" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "2,4(3H,5H)-imidazoledione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006265 ; owl:annotatedTarget "Small/hypoplastic or absent/aplastic fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006265 ; owl:annotatedTarget "Absent/small fingers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006265 ; owl:annotatedTarget "Absent/underdeveloped fingers" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "2,4-imidazolidinedione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006266 ; owl:annotatedTarget "Reduced size of the placenta." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006266 ; owl:annotatedTarget "Small placenta" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "Glycolylurea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006267 ; owl:annotatedTarget "Increased size of the placenta." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006267 ; owl:annotatedTarget "Large placenta" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006268 ; owl:annotatedTarget "Intermittently increased size of the spleen." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27612 ; owl:annotatedTarget "imidazole-2,4(3H,5H)-dione" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006270 ; owl:annotatedTarget "Underdevelopment of the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006270 ; owl:annotatedTarget "Underdeveloped spleen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006273 ; owl:annotatedTarget "The presence of lymphangiectasis in the pancreas." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006274 ; owl:annotatedTarget "Reduced number of beta cells in the pancreatic islets of Langerhans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006277 ; owl:annotatedTarget "Hyperplasia of the pancreas." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27622 ; owl:annotatedTarget "2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006278 ; owl:annotatedTarget "The presence of pancreatic tissue outside the normal pancreas, in many cases along the foregut and proximal midgut." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006278 ; owl:annotatedTarget "Abnormal pancreas location" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27622 ; owl:annotatedTarget "3-Methoxy-4-hydroxymandelate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27622 ; owl:annotatedTarget "vanilmandelate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006280 ; owl:annotatedTarget "A chronic form of pancreatitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006280 ; owl:annotatedTarget "Chronic pancreas inflammation" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "Acceptor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "A generalized form of developmental hypoplasia of the dental enamel." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "Generalised hypoplasia of dental enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "Generalised hypoplasia of tooth enamel" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "CAS:7440-48-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "Generalized hypoplasia of tooth enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "Generalised dysplasia of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006282 ; owl:annotatedTarget "Generalized dysplasia of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006283 ; owl:annotatedTarget "The presence of multiple embedded tooth germs which have failed to erupt." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006283 ; owl:annotatedTarget "Failure of eruption of multiple teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006283 ; owl:annotatedTarget "Multiple non-erupting teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006283 ; owl:annotatedTarget "Multiple unerupted teeth" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "CAS:7440-48-4" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "A decreased amount of enamel mineralization. Hypomineralized enamel has a brown discoloration and brittle aspect." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "Mottled tooth enamel" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "Poorly mineralized tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "Increased porosity of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "Fluorosis of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006285 ; owl:annotatedTarget "White spot lesions of tooth enamel" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "CAS:7440-48-4" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006286 ; owl:annotatedTarget "Yellow-brown discoloration of the teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006286 ; owl:annotatedTarget "Yellow-brown discolored teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006286 ; owl:annotatedTarget "Yellow-brown discoloured teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006286 ; owl:annotatedTarget "Yellow-brown tooth shade" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006288 ; owl:annotatedTarget "Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006288 ; owl:annotatedTarget "Advanced dental eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006288 ; owl:annotatedTarget "Early dental eruption" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006288 ; owl:annotatedTarget "Early eruption of teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006288 ; owl:annotatedTarget "Premature dental eruption" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "cobalt" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006289 ; owl:annotatedTarget "Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006289 ; owl:annotatedTarget "Absent central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006289 ; owl:annotatedTarget "Failure of development of central incisor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006289 ; owl:annotatedTarget "Absent central incisors" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "27Co" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006289 ; owl:annotatedTarget "Missing central incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "The presence of discolored lateral incisors." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Abnormality of color of front teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Abnormality of color of lateral incisor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Abnormality of colour of front teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Abnormality of colour of lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Abnormality of shade of lateral incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Discolored front teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Discoloured front teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006290 ; owl:annotatedTarget "Discoloured lateral incisors" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "Co" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006291 ; owl:annotatedTarget "Severe delay of eruption of adult teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006291 ; owl:annotatedTarget "Severe delay of eruption of permanent teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006291 ; owl:annotatedTarget "Very late eruption of adult teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006291 ; owl:annotatedTarget "Very late eruption of permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "An abnormality of tooth eruption." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Abnormality of tooth eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Anomaly of dental eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Anomaly of tooth eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Disorder of dental eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Disorder of tooth eruption" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "Co" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Disturbance of dental eruption" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006292 ; owl:annotatedTarget "Disturbance of tooth eruption" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006293 ; owl:annotatedTarget "Agenesis of upper secondary incisor or of upper central primary incisor." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "Cobalt" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006293 ; owl:annotatedTarget "Failure of development of maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006293 ; owl:annotatedTarget "Absence of maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006293 ; owl:annotatedTarget "Missing maxillary central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006293 ; owl:annotatedTarget "Missing upper central incisor" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "Kobalt" . [] oboInOwl:hasDbXref , "PMID:18499550", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Developmental hypoplasia of the dental enamel." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Defective enamel matrix" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Thin dental enamel" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Thin tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Hypoplasia of tooth enamel" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Underdeveloped teeth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006297 ; owl:annotatedTarget "Dysplasia of tooth enamel" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006298 ; owl:annotatedTarget "Prolonged bleeding post dental extraction sufficient to require medical intervention." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006298 ; owl:annotatedTarget "Prolonged bleeding after dental extraction" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "A" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "cobalt" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006302 ; owl:annotatedTarget "Dagger-shaped calcifications in the dental pulp." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006302 ; owl:annotatedTarget "Dagger shaped pulp denticles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006302 ; owl:annotatedTarget "Dagger shaped pulp stones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "cobalto" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006304 ; owl:annotatedTarget "Anterior diastema of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006304 ; owl:annotatedTarget "Gap between front teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006304 ; owl:annotatedTarget "Widely spaced front teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006304 ; owl:annotatedTarget "Diastema between front teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006304 ; owl:annotatedTarget "Diastema between incisors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27638 ; owl:annotatedTarget "cobaltum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Atrophy of alveolar margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Atrophy of alveolar processes of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Resorption of alveolar margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Resorption of alveolar processes of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Resorption of alveolar ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Shrinking of alveolar ridges" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Shrinking of gum ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Flattening of alveolar margin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27780 ; owl:annotatedTarget "detergent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Flattening of alveolar processes of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Flattening of alveolar ridges" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006308 ; owl:annotatedTarget "Flattening of gum ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "A generalized form of microdontia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Decreased size of all teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Hypotrophy of all teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Tooth mass insufficiency" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Decreased tooth mass" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Decreased width of all teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006311 ; owl:annotatedTarget "Generalised microdontia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27780 ; owl:annotatedTarget "Detergents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Increased space between the primary teeth. Note this phenotype should be distinguished from increased space due purely to microdontia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Generalised spacing of primary teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Generalized spacing of primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Wide gaps between baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Wide gaps between primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Widely spaced baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006313 ; owl:annotatedTarget "Widely spaced milk teeth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "A single maxillary central incisor positioned in the midline with morphological symmetry of the crown and bordered by lateral incisors." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Only one upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Single midline maxillary incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Single midline upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Solitary median maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Solitary midline maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006315 ; owl:annotatedTarget "Solitary median maxillary central incisor syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006316 ; owl:annotatedTarget "Irregular distribution of the teeth along the dental arch, i.e., and irregular spatial pattern of teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006316 ; owl:annotatedTarget "Irregular dental spacing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006316 ; owl:annotatedTarget "Irregularly spaced teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006316 ; owl:annotatedTarget "Variability of dental spacing" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006316 ; owl:annotatedTarget "Variability of spacing between teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Failure of eruption of multiple adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Failure of eruption of multiple permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Multiple non-erupting adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Multiple non-erupting permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Multiple unerupted adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006321 ; owl:annotatedTarget "Multiple unerupted permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Loss of the primary (also known as deciduous) teeth before the usual age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Early loss of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Early loss of deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Early loss of primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Premature loss of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Premature exfoliation of deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006323 ; owl:annotatedTarget "Premature exfoliation of primary teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006326 ; owl:annotatedTarget "Failure of dental eruption due to mucopolysaccharidoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006326 ; owl:annotatedTarget "Failure of tooth eruption due to mucopolysaccharidoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006326 ; owl:annotatedTarget "Impacted teeth due to mucopolysaccharidoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006326 ; owl:annotatedTarget "Unerupted dentition due to mucopolysaccharidoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006326 ; owl:annotatedTarget "Unerupted teeth due to mucopolysaccharidoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Underdevelopment of the alveolar process (also known as alveolar bone)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Decreased size of alveolar process of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Decreased size of alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Small alveolar process of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Small alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Underdevelopment of alveolar process of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Underdevelopment of alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Deficiency of alveolar process of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Deficiency of alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Hypotrophic alveolar process of jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006329 ; owl:annotatedTarget "Hypotrophic alveolar ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006330 ; owl:annotatedTarget "Rotated upper central incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006330 ; owl:annotatedTarget "Rotated upper front teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006330 ; owl:annotatedTarget "Turned upper front teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006330 ; owl:annotatedTarget "Twisted upper front teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006332 ; owl:annotatedTarget "The presence of a supernumerary, i.e., extra, maxillary incisor, either the primary maxillary incisor or the permanent maxillary incisor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006332 ; owl:annotatedTarget "Extra upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006333 ; owl:annotatedTarget "A type of dental misalignment with crowded central incisors, i.e., of maxillary secondary incisor, or of maxillary central primary incisor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006333 ; owl:annotatedTarget "Crowded upper front teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006333 ; owl:annotatedTarget "Crowded upper incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006333 ; owl:annotatedTarget "Overlapped maxillary incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006333 ; owl:annotatedTarget "Overlapped upper front teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "Akzeptor" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Beilstein:86196" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Developmental hypoplasia of the primary teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Decreased size of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Decreased size of deciduous teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Decreased size of milk teeth" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "CAS:54-12-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Decreased size of primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Small baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Small milk teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Small primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Underdevelopment of baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Underdevelopment of milk teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006334 ; owl:annotatedTarget "Underdevelopment of primary teeth" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "CAS:54-12-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Persistence of the primary teeth beyond the age by which they normally are shed and replaced by the permanent teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Delayed loss of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Delayed loss of deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Failure to exfoliate deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Failure to exfoliate primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Failure to lose baby teeth" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "CAS:54-12-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Persistent deciduous dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Retained baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006335 ; owl:annotatedTarget "Retained primary teeth" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Gmelin:4532" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Tooth root length more than 2 SD below mean, or subjectively apparently decreased tooth root length." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Underdeveloped tooth roots" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Decreased length of dental roots" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Decreased length of tooth roots" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Short dental roots" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Short tooth roots" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006336 ; owl:annotatedTarget "Underdeveloped dental roots" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006337 ; owl:annotatedTarget "Premature tooth eruption of the permanent dentition." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006337 ; owl:annotatedTarget "Early eruption of adult teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006337 ; owl:annotatedTarget "Early eruption of permanent teeth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006337 ; owl:annotatedTarget "Premature eruption of adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006338 ; owl:annotatedTarget "An abnormality of the morphology of secondary premolar tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006338 ; owl:annotatedTarget "Malformation of lower premolar" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006338 ; owl:annotatedTarget "Malformation of mandibular bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "An abnormal conical morphology of the primary or permanent mandibular incisors." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Cone shaped lower front tooth" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Reaxys:86196" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Conoid mandibular incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Lower front shark tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Peg shaped lower front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Peg shaped mandibular incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006339 ; owl:annotatedTarget "Pointed mandibular incisor" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Peg laterals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Peg shaped upper lateral incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Cone shaped upper lateral incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Conical maxillary lateral incisors" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Tryptophan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Conoid upper lateral incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006342 ; owl:annotatedTarget "Pointed upper lateral incisors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006344 ; owl:annotatedTarget "An abnormality of morphology of primary molar." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "tryptophan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006344 ; owl:annotatedTarget "Abnormality of deciduous molar morphology" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006344 ; owl:annotatedTarget "Abnormality of shape of baby molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006344 ; owl:annotatedTarget "Abnormality of shape of primary molar" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "Hydrogen-acceptor" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "2-amino-3-(1H-indol-3-yl)propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006346 ; owl:annotatedTarget "An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006346 ; owl:annotatedTarget "Screwdriver shaped front teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006346 ; owl:annotatedTarget "Screwdriver-shaped incisors" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Htrp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased size of the primary teeth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased size of primary tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased width of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased width of deciduous teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased width of milk teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Decreased width of primary tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006347 ; owl:annotatedTarget "Microdontia of deciduous teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "Trp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "Agenesis of permanent dentition" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "Agenesis of secondary dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "Failure of development of permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "Failure of development of secondary teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006349 ; owl:annotatedTarget "Missing teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "W" . [] oboInOwl:hasDbXref "PMID:162890", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006350 ; owl:annotatedTarget "Mineralized substance filling the entire dental pulp space." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006350 ; owl:annotatedTarget "Pulp canal obliteration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006350 ; owl:annotatedTarget "Reduced size of pulp chamber of tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006350 ; owl:annotatedTarget "Small pulp chamber of tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006350 ; owl:annotatedTarget "Narrowing of pulp chamber of tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Lack of tooth eruption of the secondary dentition." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Unerupted adult dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Unerupted adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Unerupted permanent dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Unerupted permanent teeth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "alpha-Amino-beta-(3-indolyl)-propionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006352 ; owl:annotatedTarget "Failure of eruption of adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Developmental hypoplasia of the tooth germ, i.e., of the structure that forms in odontogenesis that will develop into a tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Underdevelopment of tooth bud" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Underdevelopment of tooth germ" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Decreased size of tooth bud" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Decreased size of tooth germ" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Hypotrophic tooth germ" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Small tooth bud" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006353 ; owl:annotatedTarget "Small tooth germ" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "alpha-amino-beta-3-indolepropionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Agenesis of lower secondary incisor or lower primary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Failure of development of mandibular central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Absence of lower central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Absence of mandibular central incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "beta-3-indolylalanine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Missing lower central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006355 ; owl:annotatedTarget "Missing mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006357 ; owl:annotatedTarget "Premature loss of the permanent teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006357 ; owl:annotatedTarget "Early loss of adult teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006357 ; owl:annotatedTarget "Early loss of permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006357 ; owl:annotatedTarget "Early loss of secondary dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006357 ; owl:annotatedTarget "Premature loss of adult teeth" . [] oboInOwl:hasDbXref "PMID:2212205", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006358 ; owl:annotatedTarget "A tooth with a crown with marked lingual or palatal marginal ridges causing scooped lingual or palatal surfaces." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006358 ; owl:annotatedTarget "Shovel-shaped upper front teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "triptofano" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006361 ; owl:annotatedTarget "Irregular thighbone end part" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_27897 ; owl:annotatedTarget "tryptophane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006367 ; owl:annotatedTarget "An crumpled radiographic appearance of the long bones, as if the long bone had been crushed together producing irregularities. This feature is the result of multiple fractures and repeated rounds of ineffective healing, as can be seen for instance in severe forms of osteogenesis imperfecta." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006367 ; owl:annotatedTarget "Crumpled long bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006369 ; owl:annotatedTarget "An alteration of the normally relatively smooth margins of the kneecap in radiographic images leading to an irregular contour." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "Oxidized donor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006370 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the distal epiphysis of the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006371 ; owl:annotatedTarget "Increased width of the diaphysis of long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006371 ; owl:annotatedTarget "Broad shaft of long bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006371 ; owl:annotatedTarget "Wide shaft of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006375 ; owl:annotatedTarget "The femur is shortened and displays flaring (widening) of the metaphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006375 ; owl:annotatedTarget "Dumbbell-shaped thighbone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "Beilstein:1910407" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "CAS:150-30-1" . [] oboInOwl:hasDbXref , "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006380 ; owl:annotatedTarget "A type of knee joint contracture in which the knee is in a fixed bent (flexed) configuration such that it cannot be straightened actively or passively." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006380 ; owl:annotatedTarget "Inability to straighten knee" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006380 ; owl:annotatedTarget "Flexion contractures at both knees" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "CAS:150-30-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006381 ; owl:annotatedTarget "Small to absent calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006383 ; owl:annotatedTarget "Progressive bending or abnormal curvature of a long bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006384 ; owl:annotatedTarget "An abnormal conformation of the femur that becomes gradually enlarged towards the distal end. This feature affects the distal femoral metaphysis and epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006384 ; owl:annotatedTarget "Club-shaped outermost end of thighbone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "Gmelin:50836" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006385 ; owl:annotatedTarget "Shortening of the legs related to developmental hypoplasia of the bones of the leg." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006385 ; owl:annotatedTarget "Short legs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006385 ; owl:annotatedTarget "Short lower limbs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006386 ; owl:annotatedTarget "Underdevelopment of the distal epiphysis of the radius." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006387 ; owl:annotatedTarget "Increased width of the distal part of the shaft (metaphysis) of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006387 ; owl:annotatedTarget "Broad outermost wide portion of thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006390 ; owl:annotatedTarget "An abnormal anterior bending or curvature of the tibia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006391 ; owl:annotatedTarget "Overconstriction, or narrowness of the diaphysis and metaphysis of long bones." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "Reaxys:1910407" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006392 ; owl:annotatedTarget "An abnormal increase in the bone density of the long bones." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006392 ; owl:annotatedTarget "Increased density of long bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006394 ; owl:annotatedTarget "A limitation of the ability to place the forearm in a position such that the palm faces anteriorly (supination) and to place the forearm in a position such that the palm faces posteriorly (pronation)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006394 ; owl:annotatedTarget "Limited pronation/supination of forearm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15339 ; owl:annotatedTarget "accepteur" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "2-amino-3-phenylpropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006398 ; owl:annotatedTarget "An abnormal flattening of the distal epiphysis of femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006398 ; owl:annotatedTarget "Flat end part of outermost thighbone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "Phenylalanine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006400 ; owl:annotatedTarget "Absent knee end part" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "phenylalanine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006402 ; owl:annotatedTarget "Short outer part of limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006406 ; owl:annotatedTarget "An abnormal conformation of the femur that becomes gradually enlarged towards the proximal end. This feature affects the proximal femoral metaphysis and epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006406 ; owl:annotatedTarget "Club-shaped innermost end of thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "phenylalanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006407 ; owl:annotatedTarget "Anomaly of the contour of the Distal epiphysis of femur such that its normally smooth appearance is irregular." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006407 ; owl:annotatedTarget "Irregular outermost thighbone end part" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006408 ; owl:annotatedTarget "Tapering of outermost end of thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006409 ; owl:annotatedTarget "Progressive bending or abnormal curvature of the leg." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "DL-Phenylalanine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006413 ; owl:annotatedTarget "Broad wide portion of shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006413 ; owl:annotatedTarget "Broad wide portion of shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006414 ; owl:annotatedTarget "A bending or abnormal curvature of the distal portion of the tibia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006415 ; owl:annotatedTarget "Increased density of the compact bone of long bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "F" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006417 ; owl:annotatedTarget "Broad wide portion of thigh bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006420 ; owl:annotatedTarget "The presence of asymmetric developmental dysplasia of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "PHE" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006424 ; owl:annotatedTarget "Increased length of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "Phenylalanin" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "alpha-Amino-beta-phenylpropionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006429 ; owl:annotatedTarget "An abnormally wide femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006429 ; owl:annotatedTarget "Wide neck of thigh bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28044 ; owl:annotatedTarget "fenilalanina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006431 ; owl:annotatedTarget "An anomaly of the metaphysis of the proximal femur (close to the hip)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006431 ; owl:annotatedTarget "Abnormal wide portion of innermost thighbone" . [] oboInOwl:hasDbXref "PMID:29257019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006433 ; owl:annotatedTarget "Radial dysplasia, also known as radial longitudinal deficiency, includes radial clubhand and is a disfiguring, and potentially disabling, congenital limb anomaly. The entire upper limb may be involved, although the defect is most evident in the forearm and hand. Affected children suffer a variable degree of hypoplasia or absence of the preaxial skeleton and soft tissues, in particular the thumb, radius, and dorsoradial soft tissues. The hand is usually radially deviated and subluxated off the distal aspect of the ulna, the ulna may be shortened and have a bow-shaped deformity, and there is no true wrist (radiocarpal) joint in Bayne2 type-III and IV radial dysplasia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006433 ; owl:annotatedTarget "Dysplastic radii" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006433 ; owl:annotatedTarget "Radial longitudinal deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006434 ; owl:annotatedTarget "Proximal radial shortening owing to a congenital defect of development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006438 ; owl:annotatedTarget "An abnormal enlargement of the distal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006438 ; owl:annotatedTarget "Enlargement of the outermost thighbone end part" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28050 ; owl:annotatedTarget "Reaxys:11612459" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006440 ; owl:annotatedTarget "Increased density of shaft of long bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28050 ; owl:annotatedTarget "N-(4-aminobutanoyl)histidine" . [] oboInOwl:hasDbXref "PMID:880750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006442 ; owl:annotatedTarget "Underdevelopment or shortening of the end of the fibula (calf bone) nearest the knee." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006442 ; owl:annotatedTarget "Small innermost upper end of calf bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006442 ; owl:annotatedTarget "Underdeveloped innermost upper end of calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28050 ; owl:annotatedTarget "N-(4-aminobutyryl)histidine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006443 ; owl:annotatedTarget "Absence of the patella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006443 ; owl:annotatedTarget "Absent kneecap" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28050 ; owl:annotatedTarget "gamma-Aminobutyryl histidine" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "CAS:9005-79-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006453 ; owl:annotatedTarget "A developmental anomaly with lateral displacement of the femoral head." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "CAS:9005-79-2" . [] oboInOwl:hasDbXref , "PMID:6729496" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006454 ; owl:annotatedTarget "Formation of bone in the patella later than normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006454 ; owl:annotatedTarget "Delayed bone maturation of the knee cap" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "Glycogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006456 ; owl:annotatedTarget "Anomaly of the contour of the proximal epiphysis of the tibia such that its normally smooth appearance is irregular." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006456 ; owl:annotatedTarget "Irregular innermost shankbone end part" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006456 ; owl:annotatedTarget "Irregular innermost shinbone end part" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006459 ; owl:annotatedTarget "Partial dislocation of the ulna in the dorsal direction." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "animal starch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006461 ; owl:annotatedTarget "Slipped capital femoral epiphysis is defined as a posterior and inferior slippage of the proximal epiphysis of the femur onto the metaphysis (femoral neck), occurring through the physeal plate during the early adolescent growth spurt." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006461 ; owl:annotatedTarget "Slipped end part of innermost thighbone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28087 ; owl:annotatedTarget "liver starch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006462 ; owl:annotatedTarget "A generalized decrease in bone mineral density." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006462 ; owl:annotatedTarget "Generalised bone demineralization" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006465 ; owl:annotatedTarget "Thickening of the periosteum of long bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006467 ; owl:annotatedTarget "A limitation of the range of movement of the shoulder joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006467 ; owl:annotatedTarget "Limited shoulder movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006470 ; owl:annotatedTarget "Decreased width of the diaphysis of long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006470 ; owl:annotatedTarget "Thin shaft of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006473 ; owl:annotatedTarget "An abnormal anterior curvature of a long bone." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "CAS:13422-55-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006476 ; owl:annotatedTarget "An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "CAS:13422-55-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006477 ; owl:annotatedTarget "Any abnormality of the alveolar ridges (on the upper or lower jaws). The alveolar ridges contain the sockets (alveoli) of the teeth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006477 ; owl:annotatedTarget "Abnormality of alveolar margin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006477 ; owl:annotatedTarget "Abnormality of dentoalveolar ridges" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006477 ; owl:annotatedTarget "Abnormality of gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006477 ; owl:annotatedTarget "Abnormality of alveolar processes of jaw" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "Gmelin:124528" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006479 ; owl:annotatedTarget "An abnormality of the dental pulp." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006479 ; owl:annotatedTarget "Abnormality of tooth pulp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006479 ; owl:annotatedTarget "Endodontic abnormality" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Exfoliation of a tooth more than 2 SD earlier than the normal age for the deciduous teeth and not related to traume or neglect. Exfoliation of a permanent tooth is per se abnormal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Early tooth loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Loss of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Premature teeth loss" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Premature tooth loss" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006480 ; owl:annotatedTarget "Premature exfoliation of teeth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "Methylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006481 ; owl:annotatedTarget "Any abnormality of the primary tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006481 ; owl:annotatedTarget "Abnormality of baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006481 ; owl:annotatedTarget "Abnormality of milk teeth" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "methylcobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "An abnormality of the morphology of the tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Abnormality of dental shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Abnormality of shape of tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Abnormally shaped teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Deformity of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Dental deformity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Dental malformations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Malformation of teeth" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "CO-METHYLCOBALAMIN" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Malformed teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Misshapen teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006482 ; owl:annotatedTarget "Misshapened teeth" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "MeCbl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006483 ; owl:annotatedTarget "The presence of an altered number of of teeth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006483 ; owl:annotatedTarget "Abnormal complement of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006483 ; owl:annotatedTarget "Abnormal number of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006483 ; owl:annotatedTarget "Abnormal tooth count" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "mecobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Agenesis of incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Failure of development of incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Absence of front tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Absence of incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Missing front tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006485 ; owl:annotatedTarget "Missing incisors" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28115 ; owl:annotatedTarget "methylcob(III)alamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006486 ; owl:annotatedTarget "An abnormality of the dental root." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006486 ; owl:annotatedTarget "Abnormality of the dental root" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006486 ; owl:annotatedTarget "Abnormality of tooth root" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006487 ; owl:annotatedTarget "A bending or abnormal curvature of a long bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006487 ; owl:annotatedTarget "Bowed long bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006487 ; owl:annotatedTarget "Bowing of long bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006487 ; owl:annotatedTarget "Bowing of the long bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006488 ; owl:annotatedTarget "A bending or abnormal curvature affecting a long bone of the arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006488 ; owl:annotatedTarget "Bending of the arm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006488 ; owl:annotatedTarget "Bowing of the arm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006489 ; owl:annotatedTarget "An anomaly of the femoral metaphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006489 ; owl:annotatedTarget "Abnormality of the wide portion of the femoral bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006490 ; owl:annotatedTarget "Abnormality of the wide portion of the lower-limb bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "Beilstein:1723526" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006491 ; owl:annotatedTarget "Abnormality of the wide portion of shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006491 ; owl:annotatedTarget "Abnormality of the wide portion of shinbone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "CAS:2058-58-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006492 ; owl:annotatedTarget "Absence or underdevelopment of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006492 ; owl:annotatedTarget "Absent/small calf bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006492 ; owl:annotatedTarget "Absent/underdeveloped calf bone" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "CAS:2058-58-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006493 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of the bones of the lower limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006493 ; owl:annotatedTarget "Absent/small lower limb bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006493 ; owl:annotatedTarget "Absent/underdeveloped lower limb bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "Gmelin:101784" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006494 ; owl:annotatedTarget "Absent/small foot bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006494 ; owl:annotatedTarget "Absent/underdeveloped foot bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "PMID:767332" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006495 ; owl:annotatedTarget "Absence or underdevelopment of the ulna." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006495 ; owl:annotatedTarget "Absence/underdevelopment of inner forearm bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006495 ; owl:annotatedTarget "Absent/small ulna" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "Reaxys:1723526" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006496 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of the bones of the upper limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006496 ; owl:annotatedTarget "Absent/small bones of the upper limbs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006496 ; owl:annotatedTarget "Absent/underdeveloped bones of the upper limbs" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "D-Asparagine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006498 ; owl:annotatedTarget "Absence or underdevelopment of the patella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006498 ; owl:annotatedTarget "Absent/small kneecap" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006498 ; owl:annotatedTarget "Absent/underdeveloped kneecap" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "D-asparagine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006499 ; owl:annotatedTarget "An anomaly of a growth plate of a femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006499 ; owl:annotatedTarget "Abnormality of thighbone end part" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "(2R)-2,4-diamino-4-oxobutanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006500 ; owl:annotatedTarget "Abnormal shape of end part of lower limb end bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "(2R)-2-amino-3-carbamoylpropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006501 ; owl:annotatedTarget "A small/hypoplastic or absent/aplastic radius." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006501 ; owl:annotatedTarget "Absent/small radius" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006501 ; owl:annotatedTarget "Absent/underdeveloped radius" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "(R)-2-amino-3-carbamoylpropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006502 ; owl:annotatedTarget "Absence or underdevelopment of the carpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006502 ; owl:annotatedTarget "Absent/small wrist bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006502 ; owl:annotatedTarget "Absent/underdeveloped wrist bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "D-2-aminosuccinamic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006503 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of one or more forearm bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006503 ; owl:annotatedTarget "Absent/small forearm bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006503 ; owl:annotatedTarget "Absent/underdeveloped forearm bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006504 ; owl:annotatedTarget "Abnormality of shaft of long bone of the limbs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "D-Asparagin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "D-aspartic acid beta-amide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006505 ; owl:annotatedTarget "Abnormal shape of end part of limb bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006507 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006507 ; owl:annotatedTarget "Absent/small long bone in upper arm" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28159 ; owl:annotatedTarget "DSG" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006507 ; owl:annotatedTarget "Absent/underdeveloped long bone in upper arm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006508 ; owl:annotatedTarget "Abnormality of end part of shinbone" . [] oboInOwl:hasDbXref "PMID:18544671", "PMID:27867581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006509 ; owl:annotatedTarget "Tracheal diverticula are blind-ended outpouchings arising from the trachea. They are usually an incidental finding. Occasionally they can mimic pneumomediastinum. Tracheal diverticula are either congenital or acquired, in the latter case the most common causes are prolonged increased intraluminal pressure, e.g. chronic cough, COPD, tracheomalacia, and iatrogenic (e.g. post-surgical)." . [] oboInOwl:hasDbXref , "http://radiopaedia.org/articles/tracheal-diverticulum" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006509 ; owl:annotatedTarget "Tracheal diverticulum" . [] oboInOwl:hasDbXref "PMID:25943942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006510 ; owl:annotatedTarget "An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006510 ; owl:annotatedTarget "COPD" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "CAS:26566-61-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006511 ; owl:annotatedTarget "An abnormal high-pitched noisy sound, occurring during inhalation or exhalation caused by the incomplete obstruction in the throat." . [] oboInOwl:hasDbXref , "PMID:15316440", "PMID:16635083", "PMID:18051218" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006516 ; owl:annotatedTarget "Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen: fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache and can be completely reversible, based on the duration of the illness, categorized as acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010)." . [] oboInOwl:hasDbXref , "PMID:21900000", "PMID:22891182" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006517 ; owl:annotatedTarget "Accumulation of amorphous PAS-positive material in the space betweem alveolar macrophages, sometimes as condensed form (oval bodies) are typically found in alveolar proteinosis." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "CAS:26566-61-0" . [] oboInOwl:hasDbXref , , "PMID:20456932", "PMID:27009171" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006518 ; owl:annotatedTarget "Substantial narrowing or blockage of small pulmonary veins as a result of disorganized smooth muscle hypertrophy and collagen matrix deposition." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006519 ; owl:annotatedTarget "Adenocarcinoma of the Bronchus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006521 ; owl:annotatedTarget "Abnormal dilatation of the pulmonary lymphatic vessels. Lymphatic fluid in the lung is derived from normal leakage of fluid out of the blood capillaries in the lung. In pulmonary lymphangiectasia, the pulmonary lymphatics are not properly connected and become dilated with fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006522 ; owl:annotatedTarget "Repeated pneumothorax" . [] oboInOwl:hasDbXref , "PMID:32040879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006527 ; owl:annotatedTarget "Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:IMM_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006528 ; owl:annotatedTarget "According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006528 ; owl:annotatedTarget "Chronic lung disease" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "Galactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006529 ; owl:annotatedTarget "An abnormality of the pulmonary lymphatic chain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006530 ; owl:annotatedTarget "Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006530 ; owl:annotatedTarget "Abnormality in area between air sacs in lung" . [] oboInOwl:hasDbXref , "PMID:15750465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006532 ; owl:annotatedTarget "An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006532 ; owl:annotatedTarget "Pneumonia, recurrent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006532 ; owl:annotatedTarget "Recurrent pneumonia" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Beilstein:1721406" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "galacto-hexose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006532 ; owl:annotatedTarget "pulmonary infections, recurrent" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "galactose" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "Gal" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006535 ; owl:annotatedTarget "A recurrent hemorrhage occurring within the lung." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006535 ; owl:annotatedTarget "Recurrent bleeding into lungs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006535 ; owl:annotatedTarget "Recurrent intrapulmonary haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006535 ; owl:annotatedTarget "Recurrent pulmonary haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006535 ; owl:annotatedTarget "Recurrent pulmonary hemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006536 ; owl:annotatedTarget "Obstruction of conducting airways of the lung." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006536 ; owl:annotatedTarget "Obstructive lung disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006538 ; owl:annotatedTarget "An increased susceptibility to bronchopulmonary infections as manifested by a history of recurrent bronchopulmonary infections." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006538 ; owl:annotatedTarget "Recurrent infections in bronchi and lungs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28260 ; owl:annotatedTarget "Galaktose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006539 ; owl:annotatedTarget "Underdevelopment of the bronical cartilage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006544 ; owl:annotatedTarget "A type of pulmonary sequestration that is completely enclosed in its own pleural sac, occurring above, within, or below the diaphragm, and without communication with the tracheobronchial tree." . [] oboInOwl:hasDbXref "PMID:30386957", "PMID:788535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006548 ; owl:annotatedTarget "Pulmonary arteriovenous malformation, a condition most commonly associated with hereditary hemorrhagic telangiectasia, is an abnormal communication between the pulmonary artery and pulmonary vein without an intervening capillary communication. HRCT images usually show a coarse spidery appearance of the peripheral vascular markings in the lungs. More specific findings are obtained in the pulmonary angiogram where the normally invisible capillary phase is replaced by irregular vascular channels bridging the peripheral branches of pulmonary arteries and veins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006554 ; owl:annotatedTarget "Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006554 ; owl:annotatedTarget "Acute liver failure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006555 ; owl:annotatedTarget "A diffuse form of hepatic steatosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006558 ; owl:annotatedTarget "Decreased activity of complex III of the mitochondrion in the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006559 ; owl:annotatedTarget "The presence of abnormal calcium deposition in the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006560 ; owl:annotatedTarget "Hyperplasia of the biliary tree, as manifested by increased size of bile ducts, dilated lumen, and histologically by an increased number of epithelial cells or hyperplasia." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Beilstein:1723795" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006562 ; owl:annotatedTarget "Inflammation of the liver due to infection with a virus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006564 ; owl:annotatedTarget "Intermittently increased size of the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006565 ; owl:annotatedTarget "An abnormal increase in the amount of intracellular lipid droplets in hepatocytes." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "CAS:585-21-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006568 ; owl:annotatedTarget "An increase in the amount of glycogen stored in hepatocytes compared to normal." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "CAS:3374-22-9" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "CAS:6899-04-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006571 ; owl:annotatedTarget "The presence of reduced numbers of intrahepatic bile duct than normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006573 ; owl:annotatedTarget "An acute form of hepatic steatosis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006573 ; owl:annotatedTarget "Acute fatty liver" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006576 ; owl:annotatedTarget "Liver vascular malformations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006577 ; owl:annotatedTarget "A type of cirrhosis characterized by the presence of large regenerative nodules." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006579 ; owl:annotatedTarget "Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006579 ; owl:annotatedTarget "Prolonged yellowing of skin in newborn" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006579 ; owl:annotatedTarget "Jaundice, neonatal" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "CAS:6899-04-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006580 ; owl:annotatedTarget "Fibroblast proliferation and fiber expansion from the portal areas to the lobule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006580 ; owl:annotatedTarget "Portal fibrosis shown on biopsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006581 ; owl:annotatedTarget "An abnormal reduction in the number of mitochondria in hepatocytes." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Gmelin:27318" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006583 ; owl:annotatedTarget "Fatal liver failure in infancy" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Reaxys:1723795" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006584 ; owl:annotatedTarget "Small abnormally formed shoulder blade" . [] oboInOwl:hasDbXref , "PMID:22295044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006585 ; owl:annotatedTarget "The two portions of the clavicle (corresponding to the two primary ossification centers of the clavicle) are connected by a fibrous bridge that is contiguous with the periosteum, and a synovial membrane develops, resulting in a clavicle with a bipartite appearance radiographically. Congenital pseudarthrosis of the clavicle generally presents as a painless mass or swelling over the clavicle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006587 ; owl:annotatedTarget "An abnormally straight configuration of the clavicle, a tubular bone which normally is doubly curved ." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Glutamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006587 ; owl:annotatedTarget "Straight collarbone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006589 ; owl:annotatedTarget "Flaring of lower rib cage" . [] oboInOwl:hasDbXref , "PMID:13542801" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006590 ; owl:annotatedTarget "Prematurely closed sternal sutures." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "glutamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006591 ; owl:annotatedTarget "Lack of development of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006595 ; owl:annotatedTarget "Bony fusion between the humerus and scapula, leading to an impairment in mobility of the affected shoulder joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006595 ; owl:annotatedTarget "Fusion of shoulder blade to long bone in upper arm" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006596 ; owl:annotatedTarget "Restricted chest movement" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "2,5-diamino-5-oxopentanoic acid" . [] oboInOwl:hasDbXref , "PMID:3612666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006597 ; owl:annotatedTarget "The presence of a paralyzed diaphragm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006597 ; owl:annotatedTarget "Diaphragmatic paralysis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006597 ; owl:annotatedTarget "Paralysed diaphragm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006597 ; owl:annotatedTarget "Paralyzed diaphragm" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "2-Aminoglutaramic acid" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "2-amino-4-carbamoylbutanoic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006603 ; owl:annotatedTarget "Flared, irregular rib ends" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Glutamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006606 ; owl:annotatedTarget "Irregular surface of the normally relatively smooth border between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "CAS:3374-22-9" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Glutaminsaeure-5-amid" . [] oboInOwl:hasDbXref , "PMID:10489169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006607 ; owl:annotatedTarget "Early ossification of the costochondral junction, which is the joint between the ribs and costal cartilage in the front of the rib cage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006608 ; owl:annotatedTarget "Underdevelopment of the middle portion of the clavicle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006608 ; owl:annotatedTarget "Underdeveloped middle portion of the collarbone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "Hgln" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006610 ; owl:annotatedTarget "A larger than usual distance between the left and right nipple." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006610 ; owl:annotatedTarget "Wide-spaced nipples" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006610 ; owl:annotatedTarget "Widely spaced nipples" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006610 ; owl:annotatedTarget "Widely-spaced nipples" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28300 ; owl:annotatedTarget "glutamic acid gamma-amide" . [] oboInOwl:hasDbXref , "PMID:10204210" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006611 ; owl:annotatedTarget "A less than normal number of sternal ossification centers. The sternum is initially formed from bilateral sternal plates that chondrify and begin to fuse with ribs at 10 weeks gestational age. Ossification starts in the manubrium and upper part of the sternal body at the 6th month, in the middle of the sternal body at the 7th month, in the lower part of the body during the 1st postnatal year and in the xiphoid process between years 5 and 18. The number of ossification centers vary up to six, and it is the ossification centers that are visualized by prenatal ultrasound. This term describes a reduction in the number of ossification centers compared with age-related norms." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006611 ; owl:annotatedTarget "Decreased number of sternal ossification centres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006615 ; owl:annotatedTarget "Lack of formation and mineralization of the ribs in utero." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006615 ; owl:annotatedTarget "Absent rib calcification in utero" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006619 ; owl:annotatedTarget "Deposition of calcium salts in point-like foci within the anterior portion of one or more ribs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006623 ; owl:annotatedTarget "Abnormal increase in density of the tissue at the costochondral junctions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006625 ; owl:annotatedTarget "Breast carcinoma that is bilateral or otherwise multifocal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006628 ; owl:annotatedTarget "Lack of formation of mineralized bony tissue of the sternum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006628 ; owl:annotatedTarget "Absent bone maturation in sternum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006631 ; owl:annotatedTarget "Small distal segments of the shoulder blade" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006631 ; owl:annotatedTarget "Underdeveloped outermost segments of shoulder blade" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006633 ; owl:annotatedTarget "Underdevelopment of the glenoid fossa, which is the cavity in the lateral part of the scapula which articulates with the head of the humerus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006634 ; owl:annotatedTarget "Osteosclerosis of ribs (increased density related to increased bone mass)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006634 ; owl:annotatedTarget "Increased bone density in ribs" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "Beilstein:1209341" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006638 ; owl:annotatedTarget "Developmental defect resulting in congenital absence of the middle portion of the clavicle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006638 ; owl:annotatedTarget "Missing middle part of collarbone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "CAS:50-21-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006640 ; owl:annotatedTarget "More than one fracture of the ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006640 ; owl:annotatedTarget "Multiple rib fractures" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "CAS:50-21-5" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006641 ; owl:annotatedTarget "Prominent floating ribs" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "CAS:3374-22-9" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "CAS:50-21-5" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006642 ; owl:annotatedTarget "Large sternal ossification centres" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01050002" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006643 ; owl:annotatedTarget "Fused sternal ossification centres" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "PMID:29079364" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006645 ; owl:annotatedTarget "Abnormally reduced diameter (cross section) of the clavicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006645 ; owl:annotatedTarget "Thin collarbone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "Reaxys:1209341" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006646 ; owl:annotatedTarget "Calcification of the costal cartilages, which are bars of hyaline cartilage found at the anterior ends of the ribs which serve to prolong the ribs forward and contribute to the elasticity of the walls of the thorax." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006649 ; owl:annotatedTarget "Chest wall pain in the area of the costochondral junctions." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006650 ; owl:annotatedTarget "Thickening of the lateral border of the shoulder blade" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "rac-2-hydroxypropanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006657 ; owl:annotatedTarget "Small first rib" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006657 ; owl:annotatedTarget "Underdeveloped first rib" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "(+-)-2-hydroxypropanoic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006659 ; owl:annotatedTarget "Internally rotated shoulders" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "2-Hydroxypropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006660 ; owl:annotatedTarget "Absence of the clavicles as a developmental defect." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006660 ; owl:annotatedTarget "Absent collarbone" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006660 ; owl:annotatedTarget "Aplastic clavicles" . [] oboInOwl:hasDbXref , "PMID:12712270", "PMID:21607596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006665 ; owl:annotatedTarget "An abnormal morphology of the ribs consisting of shorted, abnormally curved ribs. On posteroanterior chest radiography, the ribs show a curvature resembling that of a coat hanger (clothes hanger)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006665 ; owl:annotatedTarget "Coat hanger sign of ribs" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "2-Hydroxypropionic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006668 ; owl:annotatedTarget "Small twelfth rib" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006668 ; owl:annotatedTarget "Underdeveloped twelfth rib" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006677 ; owl:annotatedTarget "Increased time for the complex comprised of the Q wave, R wave, and S wave as measured by the electrocardiogram (EKG).. In adults, normal values are 0.06 - 0.10 sec." . [] oboInOwl:hasDbXref , "PMID:937513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006679 ; owl:annotatedTarget "Inflammation of the coronary arteries involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "E270" . [] oboInOwl:hasDbXref , "PMID:30422584", "PMID:32063472", "PMID:32528299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Extra heart beat" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Premature ventricular contractions" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Ventricular extrasystoles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Missed heartbeat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006682 ; owl:annotatedTarget "Skipped heartbeat" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Gmelin:2933" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "Lactic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006683 ; owl:annotatedTarget "An abnormality of filling of a ventricle with blood during diastole." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006684 ; owl:annotatedTarget "A form of ventricular preexcitation due to the presence of multiple accessory pathways for cardiac conduction." . [] oboInOwl:hasDbXref , "PMID:29043203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006685 ; owl:annotatedTarget "The presence of excessive connective tissue in the endocardium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "Milchsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006687 ; owl:annotatedTarget "Abnormal tortuous (i.e., twisted) form of the aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006689 ; owl:annotatedTarget "A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006689 ; owl:annotatedTarget "Infective endocarditis" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "alpha-hydroxypropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006690 ; owl:annotatedTarget "Calcium deposition in the myocardium." . [] oboInOwl:hasDbXref "PMID:35420369" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006691 ; owl:annotatedTarget "A benign tumor of connective tissue containing mucous or gelatinous material (myxoma) localized in the pumonic valve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006692 ; owl:annotatedTarget "Abnormally short chordae tendineae of the tricuspid valve." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28358 ; owl:annotatedTarget "alpha-hydroxypropionic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28383 ; owl:annotatedTarget "alpha,omega-Dicarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006693 ; owl:annotatedTarget "Steatosis in the myocardium." . [] oboInOwl:hasDbXref , "PMID:12632326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006695 ; owl:annotatedTarget "A defect of the atrioventricular septum of the heart." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28383 ; owl:annotatedTarget "alpha(omega)-Dicarboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006695 ; owl:annotatedTarget "Hole in center of heart" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006695 ; owl:annotatedTarget "Hole in centre of heart" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006698 ; owl:annotatedTarget "A localized outpouching of ventricular cavity that is generally associated with dyskinesia and paradoxical expansion during systole." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006699 ; owl:annotatedTarget "PACs" . [] oboInOwl:hasDbXref , "PMID:20448134" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006702 ; owl:annotatedTarget "Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28383 ; owl:annotatedTarget "alpha,omega-dicarboxylic acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006703 ; owl:annotatedTarget "Absent/small lungs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006703 ; owl:annotatedTarget "Absent/underdeveloped lungs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006704 ; owl:annotatedTarget "Any structural abnormality of the coronary arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006705 ; owl:annotatedTarget "An abnormality of an atrioventricular valve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006707 ; owl:annotatedTarget "An abnormality of the hepatic vasculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006707 ; owl:annotatedTarget "Abnormality of liver blood vessels" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "CAS:12001-79-5" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006709 ; owl:annotatedTarget "Absent/small nipples" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006709 ; owl:annotatedTarget "Absent/underdeveloped nipples" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "CAS:12001-79-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006710 ; owl:annotatedTarget "Absence or underdevelopment of the clavicles (collar bones)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006710 ; owl:annotatedTarget "Absent/small collarbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006710 ; owl:annotatedTarget "Absent/underdeveloped collarbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "PMID:26413183" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006711 ; owl:annotatedTarget "Absent/small outermost thorax bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006711 ; owl:annotatedTarget "Absent/underdeveloped thorax bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "PMID:33255760" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006712 ; owl:annotatedTarget "Absent/small ribs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006712 ; owl:annotatedTarget "Absent/underdeveloped ribs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "PMID:34109217" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006713 ; owl:annotatedTarget "Absent/small shoulder blade" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006713 ; owl:annotatedTarget "Absent/underdeveloped shoulder blade" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "Vitamin K" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006714 ; owl:annotatedTarget "Absent/small sternum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006714 ; owl:annotatedTarget "Absent/underdeveloped sternum" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006715 ; owl:annotatedTarget "Tympanic nerve tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006715 ; owl:annotatedTarget "Tympanic nerve tumours" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006719 ; owl:annotatedTarget "Benign GI tract tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006719 ; owl:annotatedTarget "Benign GI tract tumours" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006719 ; owl:annotatedTarget "Benign gastrointestinal tract tumours" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006719 ; owl:annotatedTarget "Non-cancerous GI tumors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "vitamin K vitamer" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006719 ; owl:annotatedTarget "Non-cancerous GI tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006721 ; owl:annotatedTarget "A form of acute leukemia characterized by excess lympoblasts." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006721 ; owl:annotatedTarget "Acute lymphatic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006721 ; owl:annotatedTarget "Acute lymphoblastic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006721 ; owl:annotatedTarget "Acute lymphocytic leukaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006721 ; owl:annotatedTarget "Acute lymphoid leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006725 ; owl:annotatedTarget "The presence of an adenocarcinoma of the pancreas." . [] oboInOwl:hasDbXref "NCIT:C3183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006727 ; owl:annotatedTarget "Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006731 ; owl:annotatedTarget "The presence of an follicular adenocarcinoma of the thyroid gland." . [] oboInOwl:hasDbXref , "PMID:12429790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006732 ; owl:annotatedTarget "A type of papillary renal cell carcinoma in which the papillae are covered by large eosinophilic cells with pleomorphic nuclei, prominent nucleoli, and nuclear pseudostratification." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "vitamin K vitamers" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006733 ; owl:annotatedTarget "AMegL" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006733 ; owl:annotatedTarget "Acute megakaryocytic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006735 ; owl:annotatedTarget "The presence of an adenoma in the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006735 ; owl:annotatedTarget "Kidney cortical adenoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006737 ; owl:annotatedTarget "Pheochromocytoma not originating from the adrenal medulla but from another source such as from chromaffin cells in or about sympathetic ganglia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "vitamine K" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006739 ; owl:annotatedTarget "Squamous cell carcinoma of the skin is a malignant tumor of squamous epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006740 ; owl:annotatedTarget "The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006744 ; owl:annotatedTarget "A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006748 ; owl:annotatedTarget "Pheochromocytoma originating from the adrenal medulla." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006749 ; owl:annotatedTarget "Malignant GI tract tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006749 ; owl:annotatedTarget "Malignant GI tract tumours" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006749 ; owl:annotatedTarget "Malignant gastrointestinal tract tumours" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006751 ; owl:annotatedTarget "Paraspinal neurofibromas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28384 ; owl:annotatedTarget "vitamins K" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006753 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the stomach." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006753 ; owl:annotatedTarget "Stomach tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006753 ; owl:annotatedTarget "Stomach tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006755 ; owl:annotatedTarget "The presence of leiomyosarcoma of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006758 ; owl:annotatedTarget "The presence of a malignant neoplasm of the genital system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006758 ; owl:annotatedTarget "Malignant GU tract tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006758 ; owl:annotatedTarget "Malignant GU tract tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006758 ; owl:annotatedTarget "Malignant genitourinary tract tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006762 ; owl:annotatedTarget "The presence of a carcinoma in the renal pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006765 ; owl:annotatedTarget "A slowly growing malignant neoplasm derived from cartilage cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006766 ; owl:annotatedTarget "The presence of renal cell carcinoma in the renal papilla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006767 ; owl:annotatedTarget "A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006768 ; owl:annotatedTarget "Localised neuroblastoma" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "PMID:25181601" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "Beilstein:2067408" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006769 ; owl:annotatedTarget "Myxoid subcutaneous tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006770 ; owl:annotatedTarget "A subtype of renal cell carcinoma thought to originate from mature renal tubular cells in the proximal tubule of the nehpron." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006771 ; owl:annotatedTarget "A malignant epithelial tumor with a glandular organization that originates in the duodenum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006771 ; owl:annotatedTarget "Duodenal cancer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006772 ; owl:annotatedTarget "A benign renal neoplasm composed of fat, vascular, and smooth muscle elements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006772 ; owl:annotatedTarget "Kidney angiomyolipoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006774 ; owl:annotatedTarget "The presence of a papillary adenocarcinoma of the ovary." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006775 ; owl:annotatedTarget "A malignant plasma cell tumor growing within soft tissue or within the skeleton." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006775 ; owl:annotatedTarget "Kahler's disease" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "Beilstein:3227599" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006778 ; owl:annotatedTarget "A non-malignant neoplasm of the genitourinary system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006778 ; owl:annotatedTarget "Benign GU tract neoplasm" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006778 ; owl:annotatedTarget "Benign genitourinary tract tumour" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "CAS:432-70-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006780 ; owl:annotatedTarget "A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006781 ; owl:annotatedTarget "A kind of thyroid adenoma characterized by the presence of oxyphil cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Underdevelopment of the paranasal sinuses." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070258" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Small paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Decreased size of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Decreased volume of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Underdevelopment of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Decreased growth of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Decreased pneumatization of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Atelectasis of paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006784 ; owl:annotatedTarget "Hypotrophic paranasal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006785 ; owl:annotatedTarget "Muscular dystrophy affecting the muscles of the limb girdle (the hips and shoulders)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "PMID:23620017" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006794 ; owl:annotatedTarget "Loss of ability to walk in first decade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "PMID:24169341" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "PMID:9408998" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006802 ; owl:annotatedTarget "Any anomaly of the anterior horn cell." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "Reaxys:2682045" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006808 ; owl:annotatedTarget "Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006813 ; owl:annotatedTarget "Hemiclonic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006813 ; owl:annotatedTarget "Unilateral clonic seizures" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "alpha-Carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006817 ; owl:annotatedTarget "Absence or underdevelopment of the vermis of cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006817 ; owl:annotatedTarget "Cerebellar vermis aplasia or hypoplasia" . [] oboInOwl:hasDbXref , , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006818 ; owl:annotatedTarget "A form of lissencephaly in which the cortex is thickened and has four more or less disorganized layers rather than six normal layers resulting from incomplete neuronal migration during brain development. At neuropathological examination, a 4-layered cortex consists of an upper molecular layer, a second thin cellular layer containing pyramidal neurons usually observed in layer V, a third pale poorly cellular layer and a fourth thick deep layer made up of neurons which had failed to migrate. Radiologocally would manifest as agyria or pachygyria with cortical thickness greater than 10 mm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006818 ; owl:annotatedTarget "Classic lissencephaly" . [] oboInOwl:hasDbXref , "PMID:20301504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006821 ; owl:annotatedTarget "A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Reaxys:1721406" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "alpha-carotene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006827 ; owl:annotatedTarget "Degeneration of the spinal cord" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "beta,epsilon-carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006829 ; owl:annotatedTarget "A severe degree of muscular hypotonia characterized by markedly reduced muscle tone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006829 ; owl:annotatedTarget "Severely decreased muscle tone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006834 ; owl:annotatedTarget "A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills, following the onset of epilepsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006837 ; owl:annotatedTarget "A type of Horner syndrome with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006844 ; owl:annotatedTarget "Absence of the knee jerk reflex, which can normally be elicited by tapping the patellar tendon with a reflex hammer just below the patella." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28425 ; owl:annotatedTarget "all-trans-alpha-carotene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006844 ; owl:annotatedTarget "Absent knee jerk reflex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006850 ; owl:annotatedTarget "Underdevelopment of the ventral portion of the pons." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006850 ; owl:annotatedTarget "Underdeveloped ventral pons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006851 ; owl:annotatedTarget "Multiple neurofibromas of the spinal nerve roots with a symmetric distribution." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006852 ; owl:annotatedTarget "The occurrence of repeated episodes of generalized muscular hypotonia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006852 ; owl:annotatedTarget "Episodic generalised hypotonia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006855 ; owl:annotatedTarget "Wasting (atrophy) of the vermis of cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006858 ; owl:annotatedTarget "A loss or impairment of the sensation of the relative position of parts of the body and joint position occuring at distal joints." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006863 ; owl:annotatedTarget "A severe delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006866 ; owl:annotatedTarget "Midline CNS lipomas" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Beilstein:1734754" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GC_HPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006870 ; owl:annotatedTarget "A type of holoprosencephaly in which most of the right and left cerebral hemispheres and lateral ventricles are separated but the most rostral aspect of the telencephalon, the frontal lobes, are fused, especially ventrally." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006872 ; owl:annotatedTarget "Underdevelopment of the cerebrum." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "CAS:463-77-4" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006872 ; owl:annotatedTarget "Small cerebrum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006872 ; owl:annotatedTarget "Underdeveloped cerebrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006873 ; owl:annotatedTarget "A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006879 ; owl:annotatedTarget "Atrophy affecting the pons and the cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006880 ; owl:annotatedTarget "A hemangioblastoma of the cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006881 ; owl:annotatedTarget "A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006886 ; owl:annotatedTarget "A decrease in the ability to perceive vibration in the distal portions of the limbs." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "CAS:463-77-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006887 ; owl:annotatedTarget "The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006887 ; owl:annotatedTarget "Intellectual disability, progressive" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006887 ; owl:annotatedTarget "Mental retardation, progressive" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006887 ; owl:annotatedTarget "Progressive mental retardation" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Gmelin:130345" . [] oboInOwl:hasDbXref , "PMID:20537050" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006889 ; owl:annotatedTarget "Borderline intellectual disability is defined as an intelligence quotient (IQ) in the range of 70-85." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006889 ; owl:annotatedTarget "Intellectual disability, borderline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006889 ; owl:annotatedTarget "Mental retardation, borderline" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "CARBAMIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006892 ; owl:annotatedTarget "Atrophy (wasting, decrease in size of cells or tissue) affecting the frontotemporal cerebrum." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Cysteine" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Carbamic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "carbamic acid" . [] oboInOwl:hasDbXref "PMID:27358492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006896 ; owl:annotatedTarget "Fleeting perceptual experiences that occur during the transition from sleep to wakefulness." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Aminoameisensaeure" . [] oboInOwl:hasDbXref "PMID:29489275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006897 ; owl:annotatedTarget "Malfunction of the abducens nerve as manifested by impairment of the ability of the affected eye to be moved outward. Patients who develop abducens nerve palsy often present with binocular horizontal diplopia, which is a double vision when looking at objects side by side. There will be a notable weakness of the ipsilateral lateral rectus muscle leading to a deficit in of eye abduction on the affected side. Some patients may present with a constant head turning movement to maintain binocular fusion and to lessen the degree of diplopia." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006897 ; owl:annotatedTarget "Abducens nerve palsy" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006897 ; owl:annotatedTarget "Abducens nerve paralysis" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006897 ; owl:annotatedTarget "Abducens nerve paresis" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006897 ; owl:annotatedTarget "Lateral rectus muscle denervation paresis" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Aminoformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006906 ; owl:annotatedTarget "The presence of calcium deposition within brain structures that is present already at the time of birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006913 ; owl:annotatedTarget "Atrophy of the frontal cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006913 ; owl:annotatedTarget "Frontal cortex degeneration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006915 ; owl:annotatedTarget "Inability to walk by childhood/adolescence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006916 ; owl:annotatedTarget "Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Carbamate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006919 ; owl:annotatedTarget "Aggressive/violent behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0006919 ; owl:annotatedTarget "Aggressive/violent behaviour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006919 ; owl:annotatedTarget "Abnormal aggressive, impulsive or violent behaviour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28616 ; owl:annotatedTarget "Carbamidsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006921 ; owl:annotatedTarget "Stiffness (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) of the axial musculature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006927 ; owl:annotatedTarget "Excessive number of small gyri (convolutions) on the surface of one side of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006929 ; owl:annotatedTarget "Brain damage related to a lowering of blood glucose below a critical level (around 30 mg/dl), which may lead to confusion, lethargy and delirium followed by seizures and coma. Prolonged hypoglycemia may lead to irreversible brain damage." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "CAS:7723-14-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006930 ; owl:annotatedTarget "The presence of developmental dysplasia of the cortex of frontal lobe and the cortex of parietal lobe." . [] oboInOwl:hasDbXref , "PMID:30104143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006931 ; owl:annotatedTarget "Pericallosal lipomas are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006934 ; owl:annotatedTarget "Nystagmus dating from or present at birth." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "CAS:7723-14-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0006934 ; owl:annotatedTarget "Nystagmus, congenital" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006937 ; owl:annotatedTarget "A reduced sense of touch (tactile sensation) on the skin of the distal limbs. This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006937 ; owl:annotatedTarget "Decreased touch sensation in extremities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006938 ; owl:annotatedTarget "A decrease in the ability to perceive vibration at the ankles. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to the malleoli of the ankles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006938 ; owl:annotatedTarget "Decreased vibration sense at ankles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006938 ; owl:annotatedTarget "Decreased vibration sense in feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006938 ; owl:annotatedTarget "Impaired vibration sensation at ankles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006944 ; owl:annotatedTarget "A complete loss of the ability to perceive vibration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006946 ; owl:annotatedTarget "An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006955 ; owl:annotatedTarget "Hypoplasia of the cerebellum, pontine nuclei, and inferior olivary nucleus." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "Gmelin:16235" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006958 ; owl:annotatedTarget "An abnormality of the auditory evoked potentials, which are used to trace the signal generated by a sound, from the cochlear nerve, through the lateral lemniscus, to the medial geniculate nucleus, and to the cortex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "cysteine" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "phosphorus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006959 ; owl:annotatedTarget "Proximal spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "15P" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006960 ; owl:annotatedTarget "The presence of calcium deposition in the choroid plexus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006961 ; owl:annotatedTarget "Head jerking" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006961 ; owl:annotatedTarget "Jerking head movements" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006962 ; owl:annotatedTarget "Unstable walking, worse in the dark" . [] oboInOwl:hasDbXref "PMID:16808630", "PMID:18852342", "PMID:28406931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006970 ; owl:annotatedTarget "Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "P" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006970 ; owl:annotatedTarget "PVL" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming", "PMID:23705127" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006976 ; owl:annotatedTarget "A type of encephalopathy (brain disease, damage, or malfunction accompanied by an altered mental state) that is characterized by evidence of necrosis of brain tissue." . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006977 ; owl:annotatedTarget "Grammar-specific speech disorder" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "P" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006979 ; owl:annotatedTarget "Sleep-wake cycle disturbance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006980 ; owl:annotatedTarget "Leukoencephalopathy that gets more severe with time." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0006986 ; owl:annotatedTarget "Uncontrollable movement in upper arms" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "Phosphor" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:GC_HPE" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006988 ; owl:annotatedTarget "A type of holoprosencephaly characterized by the presence of a single ventricle and no separation of the cerebral hemisphere. The single midline ventricle is often greatly enlarged." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "Phosphorus" . [] oboInOwl:hasDbXref , "PMID:21263138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006989 ; owl:annotatedTarget "Dysplasia and dysgenesis of the corpus callosum are nonspecific descriptions that imply defective development of the corpus callosum. The term dysplasia is applied when the morphology of the corpus callosum is altered as a congenital trait. For instance, the corpus callosum may be hump-shaped, kinked, or a striped corpus callosum that lacks an anatomically distinct genu and splenium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006990 ; owl:annotatedTarget "A type of gliosis that occurs in the vicinity of injured neurons." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "fosforo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0006999 ; owl:annotatedTarget "Focal proliferation of glial cells in the basal ganglia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "phosphore" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007002 ; owl:annotatedTarget "Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg." . [] oboInOwl:hasDbXref , "PMID:8516046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007007 ; owl:annotatedTarget "The formation of small cavities in the tissue of the basal ganglia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28659 ; owl:annotatedTarget "phosphorus" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007009 ; owl:annotatedTarget "CNS degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007011 ; owl:annotatedTarget "Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "cysteine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007017 ; owl:annotatedTarget "Forgetfullness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "ADHD" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Attention deficit" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Attention deficit disorder" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Attention deficit-hyperactivity disorder" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Attention deficits" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007018 ; owl:annotatedTarget "Childhood attention deficit/hyperactivity disorder" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007021 ; owl:annotatedTarget "Inability to perceive painful stimuli." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007023 ; owl:annotatedTarget "Cerebral hemorrhage that occurs before birth." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "CAS:53-43-0" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007023 ; owl:annotatedTarget "Antenatal intracerebral haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007024 ; owl:annotatedTarget "Bilateral impairment of the function of the cranial nerves 9-12, which control musculature involved in eating, swallowing, and speech. Pseudobulbar paralysis is characterized clinically by dysarthria, dysphonia, and dysphagia with bifacial paralysis, and may be accompanied by Pseudobulbar behavioral symptoms such as enforced crying and laughing." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007027 ; owl:annotatedTarget "A morphological abnormality of the metencephalon." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "CAS:53-43-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007029 ; owl:annotatedTarget "A small, sac-like aneurysm (outpouching) of a cerebral blood vessel." . [] oboInOwl:hasDbXref , "PMID:25105227", "PMID:27160001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007033 ; owl:annotatedTarget "Cerebellar dysplasia (abnormal growth or development) is defined by abnormal cerebellar foliation, white matter arborization, and gray-white matter junction. Cerebellar dysplasia is a neuroimaging finding that describes abnormalities of both the cerebellar cortex and white matter and is associated with variable neurodevelopmental outcome. Dysplasia may globally involve the cerebellum or affect only one cerebellar hemisphere. In addition, cerebellar dysplasia may be associated with cortical/subcortical cysts." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007034 ; owl:annotatedTarget "Generalised hyperreflexia" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Drug_Central:795" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007036 ; owl:annotatedTarget "Underdeveloped olfactory tract" . [] oboInOwl:hasDbXref "PMID:27608867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007041 ; owl:annotatedTarget "Meningitis that persists for more than 4 weeks, and lymphocytes are present in the cerebrospinal fluid (CSF)." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02020021" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007047 ; owl:annotatedTarget "Partial or complete wasting (loss) of dentate nucleus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "PMID:14662261" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007048 ; owl:annotatedTarget "Increased size of the basal ganglia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007058 ; owl:annotatedTarget "Generalized atrophy or hypoplasia of the cerebrum." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007058 ; owl:annotatedTarget "Generalised cerebral atrophy/hypoplasia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007058 ; owl:annotatedTarget "Generalised cerebral degeneration/underdevelopment" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007058 ; owl:annotatedTarget "Generalized cerebral degeneration/underdevelopment" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007063 ; owl:annotatedTarget "Absent inferior half of the cerebellar vermis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "PMID:18634257" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007064 ; owl:annotatedTarget "Progressive loss of previously present language abilities." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007065 ; owl:annotatedTarget "Disorganisation of the anterior cerebellar vermis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007066 ; owl:annotatedTarget "Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in the proximal limb muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007067 ; owl:annotatedTarget "Peripheral sensory neuropathy affecting primarily distal sensation." . [] oboInOwl:hasDbXref , "PMID:16580298" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007068 ; owl:annotatedTarget "Underdevelopment of the inferior portion of the vermis of cerebellum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "PMID:24256992" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming", "PMID:10029348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007074 ; owl:annotatedTarget "Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007076 ; owl:annotatedTarget "Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007078 ; owl:annotatedTarget "A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "PMID:24424045" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007082 ; owl:annotatedTarget "An increase in size of the third ventricle." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "2-Amino-3-mercaptopropionic acid" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Reaxys:2058110" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007083 ; owl:annotatedTarget "Overactive knee reflex" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007083 ; owl:annotatedTarget "Brisk knee jerk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007089 ; owl:annotatedTarget "Fasciculations affecting the tongue muscle and the musculature of the face." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "3beta-hydroxyandrost-5-en-17-one" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007096 ; owl:annotatedTarget "Underdeveloped optic tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007098 ; owl:annotatedTarget "Episodes of choreoathetosis that can occur following triggers such as quick voluntary movements." . [] oboInOwl:hasDbXref , "PMID:28613730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007099 ; owl:annotatedTarget "Arnold-Chiari type I malformation refers to a relatively mild degree of herniation of the posteroinferior region of the cerebellum (the cerebellar tonsils) into the cervical canal with little or no displacement of the fourth ventricle. It is characterized by one or both pointed (not rounded) cerebellar tonsils that project 5 mm below the foramen magnum, measured by a line drawn from the basion to the opisthion (McRae Line)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007103 ; owl:annotatedTarget "A darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007105 ; owl:annotatedTarget "Encephalopathy with onset in the infantile period." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007107 ; owl:annotatedTarget "A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Dehydroepiandrosterone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007108 ; owl:annotatedTarget "Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007112 ; owl:annotatedTarget "Atrophy of the temporal cortex." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "3-BETA-HYDROXY-5-ANDROSTEN-17-ONE" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "3beta-Hydroxyandrost-5-en-17-one" . [] oboInOwl:hasDbXref , "PMID:4819905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007123 ; owl:annotatedTarget "A particular type of dementia characterized by a pattern of mental defects consisting prominently of forgetfulness, slowness of thought processes, and personality or mood change." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007126 ; owl:annotatedTarget "Amyotrophy (muscular atrophy) affecting the proximal musculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007126 ; owl:annotatedTarget "Wasting of muscles near the body" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "3beta-hydroxyandrost-5-en-17-one" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007131 ; owl:annotatedTarget "Acute progressive areflexic weakness and mild sensory changes resulting from myelin breakdown and axonal degeneration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007132 ; owl:annotatedTarget "Neurodegeneration involving the globus pallidus,a part of the basal ganglia that is involved in the regulation of voluntary movement." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007141 ; owl:annotatedTarget "Nerve damage causing decreased feeling and movement" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "3beta-hydroxyandrost-5-en-17-one" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007149 ; owl:annotatedTarget "Muscular atrophy of distal arm muscles." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "DHA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007156 ; owl:annotatedTarget "Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007158 ; owl:annotatedTarget "A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007162 ; owl:annotatedTarget "A diffuse loss of myelin from nerve fibers in the central nervous system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007164 ; owl:annotatedTarget "Slowed slurred speech" . [] oboInOwl:hasDbXref , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "A form of gray matter heterotopia were the mislocalized gray matter is typically located periventricularly, also sometimes called subependymal heterotopia. Periventricular means beside the ventricles. This is by far the most common location for heterotopia. Subependymal heterotopia present in a wide array of variations. There can be a small single node or a large number of nodes, can exist on either or both sides of the brain at any point along the higher ventricle margins, can be small or large, single or multiple, and can form a small node or a large wavy or curved mass." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "Periventricular grey matter heterotopia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "Periventricular neuronal heterotopia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "Subependymal gray matter heterotopia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "Subependymal grey matter heterotopia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007165 ; owl:annotatedTarget "Subependymal neuronal heterotopia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "DHEA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007166 ; owl:annotatedTarget "Episodic bouts of involuntary movements with dystonic, choreic, ballistic movements, or a combination thereof. There is no loss of consciousness during the attacks." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007179 ; owl:annotatedTarget "A complete lack of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007181 ; owl:annotatedTarget "Atrophy of the interosseus muscles (including the palmar interossei that lie on the anterior aspect of the metacarpals, the dorsal interosseus muscles of the hand, which lie between the intercarpals, the plantar interosseus muscles, which lie underneath the metatarsal bones, and the dorsal interossei, which are located between the metatarsal bones." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Dehydroisoandrosterone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "2-amino-3-mercaptopropanoic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Intrarosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007182 ; owl:annotatedTarget "Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007183 ; owl:annotatedTarget "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hyperintensity affecting a particular region of the basal ganglia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007185 ; owl:annotatedTarget "Loss of consciousness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007185 ; owl:annotatedTarget "Passing out" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007187 ; owl:annotatedTarget "A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure that affects a particular part of the cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007188 ; owl:annotatedTarget "Facial diplegia (that is, bilateral facial palsy) with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007188 ; owl:annotatedTarget "Congenital bilateral facial palsy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007188 ; owl:annotatedTarget "Congenital bilateral facial weakness" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28689 ; owl:annotatedTarget "Prasterone" . [] oboInOwl:hasDbXref , "PMID:24395517", "PMID:26948972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007193 ; owl:annotatedTarget "Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007193 ; owl:annotatedTarget "Generalised tonic-clonic seizures on awakening" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007193 ; owl:annotatedTarget "Morning generalised tonic-clonic seizures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007193 ; owl:annotatedTarget "Morning generalized tonic-clonic seizures" . [] oboInOwl:hasDbXref , "PMID:31420554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007201 ; owl:annotatedTarget "The formation of the formation of fibrofatty lesions in the wall of an artery located in the brain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007201 ; owl:annotatedTarget "Plaque build-up in cerebral artery" . [] oboInOwl:hasDbXref , "PMID:17416820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007206 ; owl:annotatedTarget "Enlargement of all or parts of one cerebral hemisphere." . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007207 ; owl:annotatedTarget "Generalized-onset tonic-clonic seizures that are provoked by flashing or flickering light." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007207 ; owl:annotatedTarget "Photosensitive tonic-clonic seizures" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "CAS:7440-50-8" . [] oboInOwl:hasDbXref "PMID:20301641", "PMID:8817346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007208 ; owl:annotatedTarget "Presence of irregular redundant loops of focally folded myelin in a peripheral nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007209 ; owl:annotatedTarget "Complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007209 ; owl:annotatedTarget "Facial paralysis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "CAS:7440-50-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007209 ; owl:annotatedTarget "Facial paresis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007210 ; owl:annotatedTarget "Muscular atrophy affecting the lower limb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007215 ; owl:annotatedTarget "Episodes of muscle weakness associated with elevated levels of potassium in the blood." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "Gmelin:16269" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007220 ; owl:annotatedTarget "Demyelination of peripheral motor nerves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007227 ; owl:annotatedTarget "Increased size of cerebral gyri, often associated with a moderate reduction in the number of sulci of the cerebrum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "copper" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007229 ; owl:annotatedTarget "The presence of calcium deposition in the cerebral white matter surrounding the cerebral ventricles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007230 ; owl:annotatedTarget "A reduction in the amplitude of sensory nerve action potential in distal nerve segments. This feature is measured by nerve conduction studies." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jbaets" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007233 ; owl:annotatedTarget "Groups of small caliber axons in peripheral nerve biospies indicative of axonal regeneration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007240 ; owl:annotatedTarget "A type of gait ataxia displaying progression of clinical severity." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007249 ; owl:annotatedTarget "Decreased number of small peripheral myelinated nerve fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007250 ; owl:annotatedTarget "Alternating and recurrent weakness of the external ocular muscles." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "29Cu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007256 ; owl:annotatedTarget "Functional neurological abnormalities related to dysfunction of the pyramidal tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007258 ; owl:annotatedTarget "A severe loss of myelin from nerve fibers in the central nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007260 ; owl:annotatedTarget "A form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007262 ; owl:annotatedTarget "A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007263 ; owl:annotatedTarget "Atrophy affecting the cerebellum and the spinocerebellar tracts of the spinal cord." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "Copper" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007265 ; owl:annotatedTarget "Agenesis of the midbrain." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "2-amino-3-sulfanylpropanoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "Cu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007266 ; owl:annotatedTarget "Defective structure and function of myelin sheaths of the white matter of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007267 ; owl:annotatedTarget "An abnormality characterized by chronic impairment of the normal functioning of the axons." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "Cu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007269 ; owl:annotatedTarget "Muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "Kupfer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007269 ; owl:annotatedTarget "Spinal muscle degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007269 ; owl:annotatedTarget "Spinal muscle wasting" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276062", "PMID:28276064", "PMID:6790275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007270 ; owl:annotatedTarget "An atypical absence seizure is a type of generalised non-motor (absence) seizure characterised by interruption of ongoing activities and reduced responsiveness. In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007270 ; owl:annotatedTarget "Atypical absence seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007270 ; owl:annotatedTarget "Atypical petit mal seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007274 ; owl:annotatedTarget "An increased susceptibility to bacterial meningitis as manifested by a medical history of recurrent episodes of bacterial meningitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007281 ; owl:annotatedTarget "A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007285 ; owl:annotatedTarget "Paralysis of the facial nerves on the basis of overgrowth of the cranial bones causing impingement upon the seventh cranial nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007285 ; owl:annotatedTarget "Facial palsy caused by enlargement of cranial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007285 ; owl:annotatedTarget "Facial palsy caused by excessive growth of facial bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "cobre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007285 ; owl:annotatedTarget "Facial palsy caused by overgrowth of cranial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007285 ; owl:annotatedTarget "Facial palsy secondary to hypertrophy of cranial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007286 ; owl:annotatedTarget "Nystagmus consisting of horizontal to-and-fro eye movements, in which the movement in one direction is faster than in the other." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007289 ; owl:annotatedTarget "Fasciculations affecting the musculature of the arms and legs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "copper" . [] oboInOwl:hasDbXref , "PMID:2816648" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007291 ; owl:annotatedTarget "A discrete posterior fossa cerebrospinal fluid (CSF) collection that does not communicate directly with the fourth ventricle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "cuivre" . [] oboInOwl:hasDbXref "PMID:26275812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007301 ; owl:annotatedTarget "Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28694 ; owl:annotatedTarget "cuprum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007302 ; owl:annotatedTarget "Bipolar disorder" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007305 ; owl:annotatedTarget "A loss of myelin from nerve fibers in the central nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007311 ; owl:annotatedTarget "Short stepped shuffling walk" . [] oboInOwl:hasDbXref , "PMID:16239634" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007321 ; owl:annotatedTarget "Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007325 ; owl:annotatedTarget "A type of dystonia that affects all or most of the body." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007325 ; owl:annotatedTarget "Generalised dystonia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007328 ; owl:annotatedTarget "Reduced ability to perceive painful stimuli." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007328 ; owl:annotatedTarget "Decreased pain sensation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007328 ; owl:annotatedTarget "Impaired pain sensation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "Beilstein:1721906" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007332 ; owl:annotatedTarget "Focal seizure characterized at onset by clonic movements affecting half of the face." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "C" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "CAS:6706-59-8" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007332 ; owl:annotatedTarget "Hemifacial seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007333 ; owl:annotatedTarget "Underdevelopment of the frontal lobe of the cerebrum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007333 ; owl:annotatedTarget "Underdeveloped frontal lobe" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "CAS:6706-59-8" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "Generalised tonic-clonic seizures with focal onset" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "Generalized tonic-clonic seizures with focal onset" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "Partial seizures with secondary generalisation" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "Secondary generalised tonic clonic seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007334 ; owl:annotatedTarget "Secondary generalised tonic-clonic seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007335 ; owl:annotatedTarget "Recurrent episodes of brain dysfunction that may be triggered by factors such as metabolic disturbances or infections." . [] oboInOwl:hasDbXref , "PMID:572501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007338 ; owl:annotatedTarget "A saccade that overshoots the target with the dynamic saccade." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "Gmelin:648560" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Weakness of the muscles of the legs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Lower extremity weakness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Lower limb muscle weakness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Lower limb weakness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Muscle weakness in lower limbs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "PMID:19695255" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007340 ; owl:annotatedTarget "Leg weakness" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "Reaxys:1721906" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-Glucitol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-glucitol" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-glucitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007351 ; owl:annotatedTarget "A type of tremors that is triggered by holding an arm in a fixed position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007354 ; owl:annotatedTarget "Lou Gehrig's disease" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007359 ; owl:annotatedTarget "A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-glucitol" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007359 ; owl:annotatedTarget "Focal seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007359 ; owl:annotatedTarget "Focal-onset seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007359 ; owl:annotatedTarget "Partial seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007359 ; owl:annotatedTarget "Seizure affecting one half of brain" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "(2R,3S,4S,5S)-hexane-1,2,3,4,5,6-hexol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007360 ; owl:annotatedTarget "Absent/small cerebellum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007360 ; owl:annotatedTarget "Absent/underdeveloped cerebellum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Cys" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "D-Gulitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007361 ; owl:annotatedTarget "A structural abnormality of the pons." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007362 ; owl:annotatedTarget "Absent/small brainstem" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007362 ; owl:annotatedTarget "Absent/underdeveloped brainstem" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "D-gulitol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007364 ; owl:annotatedTarget "Absent/small cerebrum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007364 ; owl:annotatedTarget "Absent/underdeveloped cerebrum" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-Sorbitol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28789 ; owl:annotatedTarget "L-sorbitol" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007367 ; owl:annotatedTarget "Atrophy/Degeneration affecting the CNS" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007369 ; owl:annotatedTarget "The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007370 ; owl:annotatedTarget "Absence or underdevelopment of the corpus callosum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007371 ; owl:annotatedTarget "The presence of atrophy (wasting) of the corpus callosum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007373 ; owl:annotatedTarget "Wasting involving the motor neuron." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007373 ; owl:annotatedTarget "Motor neuron degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007375 ; owl:annotatedTarget "An abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "Beilstein:143524" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007376 ; owl:annotatedTarget "An abnormality of the choroid plexus, which is the area in the cerebral ventricles in which cerebrospinal fluid is produced by modified ependymal cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007377 ; owl:annotatedTarget "An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the gastrointestinal tract." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "GI tract tumor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Cystein" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "CAS:50-67-9" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "GI tract tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "Gastrointestinal tract tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "Gastrointestinal tract tumour" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007378 ; owl:annotatedTarget "Neoplasm of the GI tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007379 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the genitourinary system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007379 ; owl:annotatedTarget "Genitourinary tract tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007379 ; owl:annotatedTarget "Genitourinary tract tumours" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007379 ; owl:annotatedTarget "Neoplasm of the GU tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007380 ; owl:annotatedTarget "Telangiectases (small dilated blood vessels) located near the surface of the skin of the face." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007383 ; owl:annotatedTarget "Congenital localised absence of skin" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "CAS:50-67-9" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007383 ; owl:annotatedTarget "Congenital localised skin absence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007385 ; owl:annotatedTarget "A developmental defect resulting in the congenital absence of skin on the scalp." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007385 ; owl:annotatedTarget "Focal absence of scalp tissue" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "Gmelin:1861995" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007385 ; owl:annotatedTarget "Solitary scalp defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007387 ; owl:annotatedTarget "Underdevelopment of the sweat glands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007387 ; owl:annotatedTarget "Underdeveloped sweat glands" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "PMID:18593914" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007392 ; owl:annotatedTarget "Excessive wrinkled skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007394 ; owl:annotatedTarget "Prominent superficial blood vessels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007394 ; owl:annotatedTarget "Prominent superficial vasculature" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007395 ; owl:annotatedTarget "A type of ichthyosiform erythroderma with postnatal onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007396 ; owl:annotatedTarget "Photosensitivity of the skin occurring early in life." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007396 ; owl:annotatedTarget "Sun sensitivity occurring early in life" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "PMID:24136337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007397 ; owl:annotatedTarget "Developmental hypoplasia of the apocrine sweat glands in the region of the axilla." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "Reaxys:143524" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007401 ; owl:annotatedTarget "Well-demarcated area(s) of partial or complete depigmentation in the macula, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "3-(2-aminoethyl)-1H-indol-5-ol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007403 ; owl:annotatedTarget "Thick skin of soles" . [] oboInOwl:hasDbXref "PMID:7528239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007404 ; owl:annotatedTarget "Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "SEROTONIN" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007406 ; owl:annotatedTarget "Dark eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007406 ; owl:annotatedTarget "Brown eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007406 ; owl:annotatedTarget "Pigmentation of eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007407 ; owl:annotatedTarget "Excessive skin wrinkling on back of hands and fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007408 ; owl:annotatedTarget "Increased susceptibility to infection by the protozan parasite of the genus Leishmania." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007410 ; owl:annotatedTarget "An abnormally increased perspiration on palms and soles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007410 ; owl:annotatedTarget "Excessive sweating of palms and soles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "Serotonin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007413 ; owl:annotatedTarget "Naevus flammeus localised in the skin of the forehead." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007413 ; owl:annotatedTarget "Port-wine stain on forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007414 ; owl:annotatedTarget "Wrinkled skin of hands and feet in newborn" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Hcys" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "3-(2-Aminoethyl)-1H-indol-5-ol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007418 ; owl:annotatedTarget "Loss of all scalp hair." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007420 ; owl:annotatedTarget "Spontaneous development of hematomas (hematoma) or bruises without significant trauma." . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "5-HT" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007421 ; owl:annotatedTarget "Telangiectases (small dilated blood vessels) located near the surface of the skin of the cheeks." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007421 ; owl:annotatedTarget "Telangiectasia on the cheeks" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007425 ; owl:annotatedTarget "Hyperelastic face skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007425 ; owl:annotatedTarget "Stretchable face skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007427 ; owl:annotatedTarget "Reticular pigmentation pattern" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007427 ; owl:annotatedTarget "Reticulate skin pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007428 ; owl:annotatedTarget "Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the oral mucosa." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "5-Hydroxytryptamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007428 ; owl:annotatedTarget "Angioectasia of the oral mucosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007428 ; owl:annotatedTarget "Angioectasia of the oral mucous membrane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007428 ; owl:annotatedTarget "Spider veins of the oral mucosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007428 ; owl:annotatedTarget "Telangiectasia of the oral mucous membrane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007429 ; owl:annotatedTarget "The presence of two to five cafe-au-lait macules." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "Enteramine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007430 ; owl:annotatedTarget "Generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007430 ; owl:annotatedTarget "Generalised oedema" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007430 ; owl:annotatedTarget "Generalised tissue oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007431 ; owl:annotatedTarget "An ichthyosiform abnormality of the skin with congenital onset." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007432 ; owl:annotatedTarget "Intermittent generalised erythematous papular rash" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007434 ; owl:annotatedTarget "Hemangioma is a benign tumor of the vascular endothelial cells. This term refers to facial hemangiomas that have a plaque-like morphology." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "serotonine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007437 ; owl:annotatedTarget "The presence of multiple leiomyomas of the skin." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007439 ; owl:annotatedTarget "Generalised keratosis follicularis" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "thrombocytin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007440 ; owl:annotatedTarget "Generalised hyperpigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007443 ; owl:annotatedTarget "Absence of melanin pigment in various areas, which is found at birth and is permanent. The lesions are known as leucoderma and are often found on the face, trunk, or limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007443 ; owl:annotatedTarget "Partial absent skin pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007446 ; owl:annotatedTarget "A type of blistering that affects the skin of the palms of the hands and the soles of the feet." . [] oboInOwl:hasDbXref "PMID:17298101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007447 ; owl:annotatedTarget "Diffuse abnormal thickening of the skin on the palms and soles." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28790 ; owl:annotatedTarget "thrombotonin" . [] oboInOwl:hasDbXref "PMID:29763176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007451 ; owl:annotatedTarget "Inability to sweat on the same side of the face that is affected by ptosis and miosis. This is a feature of Horner syndrome." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007453 ; owl:annotatedTarget "Lichenification affecting primarily flexural areas of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007457 ; owl:annotatedTarget "Prominent thoracic and abdominal veins." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007459 ; owl:annotatedTarget "Generalised anhidrosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007459 ; owl:annotatedTarget "Generalised anhydrosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007459 ; owl:annotatedTarget "Generalised inability to sweat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007459 ; owl:annotatedTarget "Generalized inability to sweat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007462 ; owl:annotatedTarget "Keratinization of the bulbar conjunctiva near the limbus (corneoscleral junction), resulting in a raised spot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007464 ; owl:annotatedTarget "Reduced number or density of facial hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007464 ; owl:annotatedTarget "Sparse facial hair" . [] oboInOwl:hasDbXref "PMID:9326323" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007465 ; owl:annotatedTarget "Abnormal thickening of the skin on the palms and soles with an honeycomb pattern." . [] oboInOwl:hasDbXref "PMID:23044575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007468 ; owl:annotatedTarget "Increased amount of keratin (visible as white scales) surrounding hair follicles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007469 ; owl:annotatedTarget "Cutis gyrata of palms and soles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007470 ; owl:annotatedTarget "Subcutaneous nodules that are located in the vicinity of joints." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007475 ; owl:annotatedTarget "An ichthyosiform abnormality of the skin that presents at birth or shortly thereafter with generalized erythema, blistering, erosions, and peeling. In the subsequent months, erythema and blistering improves but patients go on to develop hyperkeratotic scaling that is especially prominent along the joint flexures, neck, hands and feet." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "Zystein" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Beilstein:8186767" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007477 ; owl:annotatedTarget "An abnormality of dermatoglyphs (fingerprints), which are present on fingers, palms, toes, and soles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007477 ; owl:annotatedTarget "Abnormal fingerprints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007479 ; owl:annotatedTarget "The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007482 ; owl:annotatedTarget "Generalised papillary lesions" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "CAS:9050-30-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007485 ; owl:annotatedTarget "Lack of subcutaneous adipose tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007485 ; owl:annotatedTarget "Absent fat below the skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007485 ; owl:annotatedTarget "Lack of fatty tissue below the skin" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "CAS:9050-30-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007489 ; owl:annotatedTarget "Telangiectases (small dilated blood vessels) with a diffuse localization." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007495 ; owl:annotatedTarget "Precociously senile appearance" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007495 ; owl:annotatedTarget "Prematurely aged appearance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007497 ; owl:annotatedTarget "Hyperkeratosis affecting the palm of the hand and the sole of the foot in areas exposed to friction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007499 ; owl:annotatedTarget "Increased susceptibility to staphylococcal infections, as manifested by recurrent episodes of staphylococcal infections." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007499 ; owl:annotatedTarget "Recurrent staphylococcal infections" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "PMID:8713797" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007500 ; owl:annotatedTarget "The presence of fewer than normal sweat glands." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007500 ; owl:annotatedTarget "Decreased sweat glands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007500 ; owl:annotatedTarget "Decreased sweat pores" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007502 ; owl:annotatedTarget "A skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules resulting from closure of hair follicles with a white plug of sebum." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007503 ; owl:annotatedTarget "Generalised ichthyosis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007506 ; owl:annotatedTarget "Missing skin on limbs since birth" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparan sulfate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparan N-sulfate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007513 ; owl:annotatedTarget "Fair skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007513 ; owl:annotatedTarget "Generalised hypopigmentation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007513 ; owl:annotatedTarget "Pale pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007514 ; owl:annotatedTarget "An abnormal accumulation of fluid beneath the skin on the back of the hands." . [] a owl:Axiom ; rdfs:label "Oedema hands" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0007514 ; owl:annotatedTarget "MEDDRA:10058204" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007514 ; owl:annotatedTarget "Oedema of dorsum of hands" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007514 ; owl:annotatedTarget "Oedema of the dorsum of hands" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparan sulphate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007516 ; owl:annotatedTarget "Loose and sagging skin of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007516 ; owl:annotatedTarget "Extra skin on fingers" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparatan sulfate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007517 ; owl:annotatedTarget "Loose, wrinkled skin of hands and feet." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007517 ; owl:annotatedTarget "Excessive wrinkled skin of palms and soles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparin monosulfate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007517 ; owl:annotatedTarget "Increased wrinkles of palms and soles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007517 ; owl:annotatedTarget "Wrinkled palms and soles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007517 ; owl:annotatedTarget "Wrinkled skin of hands and feet" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparin sulfate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007522 ; owl:annotatedTarget "Increased number of skin folds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007526 ; owl:annotatedTarget "Patchy loss of skin color on arms" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007526 ; owl:annotatedTarget "Patchy loss of skin colour on arms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007534 ; owl:annotatedTarget "Loss of hair in the occipital region of the scalp with congenital onset." . _:genid60195 a owl:Class, owl:Restriction ; owl:intersectionOf (obo:PATO_0000927 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom obo:UBERON_0010230 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000396 ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0019200 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15356 ; owl:annotatedTarget "cisteina" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparitin monosulfate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007537 ; owl:annotatedTarget "A severe degree of photosensitivity of the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007537 ; owl:annotatedTarget "Severe sun sensitivity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007541 ; owl:annotatedTarget "Presence of a cutaneous lipoma on the forehead." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "Heparitin sulfate" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0007542 ; owl:annotatedTarget _:genid60195 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007542 ; owl:annotatedTarget "Lack of skin pigmentation (coloring) of the anterior chest." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28815 ; owl:annotatedTarget "N-Acetylheparan sulfate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007543 ; owl:annotatedTarget "Increased thickness of skin epidermis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007544 ; owl:annotatedTarget "Piebaldism is characterized by stable and persistent, well-circumscribed depigmented patches present at birth affecting the skin of the face, trunk, and extremities in a symmetrical distribution." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007550 ; owl:annotatedTarget "Lack of sweating or excessive sweating" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007552 ; owl:annotatedTarget "Abnormal fat tissue distribution below the skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007554 ; owl:annotatedTarget "Confetti hypopigmentation pattern of lower leg skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007556 ; owl:annotatedTarget "Hyperkeratosis affecting the sole of the foot." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007559 ; owl:annotatedTarget "Localised epidermolytic hyperkeratosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007565 ; owl:annotatedTarget "The presence of six or more cafe-au-lait spots." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007565 ; owl:annotatedTarget "Multiple birthmarks" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007565 ; owl:annotatedTarget "Multiple flat light-brown marks on skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007569 ; owl:annotatedTarget "Generalised seborrheic dermatitis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007569 ; owl:annotatedTarget "Generalised seborrheic eczema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007569 ; owl:annotatedTarget "Generalized seborrheic eczema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007570 ; owl:annotatedTarget "Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a keratinization abnormality characterized by small, asymptomatic erythematous papules that leave characteristic punctate bleeding when they become detached. The lesions generally occur symmetrically along the top of the foot and on the legs, appearing more rarely on the arms, forearms, palms, and soles, and even on the oral mucosa." . [] oboInOwl:hasDbXref "PMID:23984225", "PMID:27904186" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007573 ; owl:annotatedTarget "A form of atopic dermatitis with onset in adulthood characterized by atopic red face, chronic lichenified eczema on the trunk, subacute or psoriasiform dermatitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007573 ; owl:annotatedTarget "Late onset baby eczema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007574 ; owl:annotatedTarget "Bronze skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007574 ; owl:annotatedTarget "Generalised bronze hyperpigmentation" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007576 ; owl:annotatedTarget "Palmar neurofibromas" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007587 ; owl:annotatedTarget "Numerous pigmented freckles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007588 ; owl:annotatedTarget "Increased pigmentation of the skin with a netlike (reticular) pattern." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007589 ; owl:annotatedTarget "A developmental defect resulting in the congenital absence of skin on the trunk or the limbs." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Beilstein:2068550" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007592 ; owl:annotatedTarget "Absence or developmental hypoplasia of the eccrine sweat glands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007595 ; owl:annotatedTarget "Excess skin in infancy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007596 ; owl:annotatedTarget "The presence of multiple subcutaneous lipoma that cause pain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007596 ; owl:annotatedTarget "Painful noncancerous fat tissue tumor under the skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007596 ; owl:annotatedTarget "Painful noncancerous fat tissue tumour under the skin" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "CAS:127-40-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007598 ; owl:annotatedTarget "The distal and proximal transverse palmar creases are merged into a single transverse palmar crease on both hands." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007599 ; owl:annotatedTarget "Generalised reticulate brown pigmentation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007603 ; owl:annotatedTarget "Freckles in sun-exposed areas" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "CAS:127-40-2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007605 ; owl:annotatedTarget "Redundant, wrinkled skin of palms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007609 ; owl:annotatedTarget "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body because of decreased osmotic pressure of plasma (hypoproteinemia)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007609 ; owl:annotatedTarget "Hypoproteinemic oedema" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Drug_Central:4145" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007616 ; owl:annotatedTarget "Naevus flammeus localised in the skin of the neck. This is one of the most common birthmarks and present in approximately 25% of all newborns." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007616 ; owl:annotatedTarget "Port-wine stain on neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007616 ; owl:annotatedTarget "Stork bite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007616 ; owl:annotatedTarget "Angel's kiss" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007616 ; owl:annotatedTarget "Salmon patch" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070274" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007618 ; owl:annotatedTarget "Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007618 ; owl:annotatedTarget "Skin calcification" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007620 ; owl:annotatedTarget "The presence of leiomyoma of the skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007623 ; owl:annotatedTarget "Abnormal pigmentation in sun-exposed skin" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "PMID:10714278" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007626 ; owl:annotatedTarget "Lower jaw bone infection" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "PMID:14670087" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Underdevelopment of condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Absence of the condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Absence of the condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Absence of the condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Failure of development of condylar head of mandible" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "PMID:23543147" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Failure of development of condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Failure of development of the condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Underdevelopment of condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Underdevelopment of condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Agenesis of condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Agenesis of condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007627 ; owl:annotatedTarget "Agenesis of condylar process of mandible" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "PMID:24451312" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Decreased size of condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Decreased size of mandibular condyle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypoplasia of condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypoplasia of mandibular condyle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypoplasia of subcondylar region of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Small mandibular condyle" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Reaxys:2068550" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypoplasia of condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypoplasia of condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Small condylar head of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Small condylar neck of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypotrophic condylar process of mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007628 ; owl:annotatedTarget "Hypotrophic mandibular condyle" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "(3R,3'R,6'R)-beta,epsilon-carotene-3,3'-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007633 ; owl:annotatedTarget "A developmental anomaly characterized by abnormal smallness of both eyes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007633 ; owl:annotatedTarget "Decreased size of eyeballs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007633 ; owl:annotatedTarget "Decreased size of globes of eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007633 ; owl:annotatedTarget "Abnormally small eyeball on both sides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007633 ; owl:annotatedTarget "Bilateral nanophthalmos" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Lutein" . [] oboInOwl:hasDbXref , "PMID:17698200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007634 ; owl:annotatedTarget "An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disc or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007634 ; owl:annotatedTarget "Nonarteritic anterior ischaemic optic neuropathy" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007641 ; owl:annotatedTarget "A form of colorblindness in which only two of the three fundamental colors can be distinguished due to a lack of one of the retinal cone pigments." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007641 ; owl:annotatedTarget "Color blindness" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007641 ; owl:annotatedTarget "Colour blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "A nonprogressive (i.e., stationary) form of difficulties with night blindness with congenital onset." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "Night blindness since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "Night blindness, congenital" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "Night blindness, congenital stationary" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "Night blindness, congenital stationary, complete" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "lutein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007642 ; owl:annotatedTarget "Night blindness, stationary" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007646 ; owl:annotatedTarget "Lack of eyelashes on the lower lid." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007646 ; owl:annotatedTarget "Absent lower eyelashes" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "(3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007646 ; owl:annotatedTarget "Failure of development of lower eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007646 ; owl:annotatedTarget "Agenesis of lower eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007646 ; owl:annotatedTarget "Aplasia of lower eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007647 ; owl:annotatedTarget "Congenital abnormality of the extraocular muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007648 ; owl:annotatedTarget "A type of cataract with punctate opacities of the lens." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007649 ; owl:annotatedTarget "Sharply demarcated, congenital hyperpigmentation of the retinal pigment epithelium." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Bo-Xan" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007651 ; owl:annotatedTarget "Lower eyelid folded out" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007651 ; owl:annotatedTarget "Lower eyelid turned out" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "E 161b" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007656 ; owl:annotatedTarget "A congenital defect of development characterized by absence of the lacrimal gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007656 ; owl:annotatedTarget "Absent tear gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007657 ; owl:annotatedTarget "Opacity of the entire lens nucleus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28838 ; owl:annotatedTarget "Xanthophyll" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007663 ; owl:annotatedTarget "Decreased clarity of vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007665 ; owl:annotatedTarget "Abnormally curly or curved eyelashes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007665 ; owl:annotatedTarget "Curly eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007667 ; owl:annotatedTarget "Degenerative changes of the peripheral retina consisting of close-packed tiny cystic spaces at the outer plexiform/inner nuclear retinal level. The degeneration is very common in adult eyes and starts adjacent to the ora serrata and extends circumferentially and posteriorly." . [] oboInOwl:hasDbXref , "PMID:3625219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007670 ; owl:annotatedTarget "An abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007675 ; owl:annotatedTarget "Progressive night blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007676 ; owl:annotatedTarget "Congenital underdevelopment of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007676 ; owl:annotatedTarget "Underdeveloped iris" . _:genid60469 oboInOwl:hasDbXref , "PMID:18289629" ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007677 ; owl:annotatedTarget "Vitelliform maculopathy is a sharply demarcated lesion caused by the accumulation of material, often lipofuscin in the subretinal space underlying the macula." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000462 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0043473 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0003951 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007678 ; owl:annotatedTarget "Narrowing of a tear duct (lacrimal duct)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007678 ; owl:annotatedTarget "Narrowing of the tear duct" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0007680 ; owl:annotatedTarget _:genid60469 . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Beilstein:608585" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007686 ; owl:annotatedTarget "A functional abnormality of the pupil." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007687 ; owl:annotatedTarget "A unilateral form of ptosis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007687 ; owl:annotatedTarget "Dropping of one upper eyelid" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "CAS:57-11-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007688 ; owl:annotatedTarget "Absence of the combined rod-and-cone response on electroretinogram." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007695 ; owl:annotatedTarget "An abnormality of the reflex that controls the diameter of the pupil, in response to the intensity of light that falls on the retina of the eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Underdevelopment of the lower eyelid." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "CAS:57-11-4" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Small lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Decreased size of lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Underdevelopment of lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Short lower eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007697 ; owl:annotatedTarget "Hypotrophic lower eyelid" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Drug_Central:4611" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007700 ; owl:annotatedTarget "Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Gmelin:11738" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007704 ; owl:annotatedTarget "Sudden-onset episode of abnormal, involuntary eye movements." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010018" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007707 ; owl:annotatedTarget "Absence of the crystalline lens of the eye as a result of a developmental defect." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007708 ; owl:annotatedTarget "Absent inner eyelashes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:11425337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007716 ; owl:annotatedTarget "A malignant melanoma originating within the eye. The tumor originates from the melanocytes in the uvea (which comprises the iris, ciliary body, and choroid)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007717 ; owl:annotatedTarget "A chronic irritative conjunctivitis, which commonly presents with general irritation and redness of the eyes, with a burning, dry, or foreign-body sensation of the eyes." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:16448636" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007720 ; owl:annotatedTarget "Cornea plana is an abnormally flat shape of the cornea such that the normal protrusion of the cornea from the sclera is missing. The reduced corneal curvature can lead to hyperopia, and a hazy corneal limbus and arcus lipoides may develop at an early age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007721 ; owl:annotatedTarget "Presence of multiple dilatations (sac-like outpouchings) in the blood vessels of the conjunctiva." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007722 ; owl:annotatedTarget "Atrophy (loss or wasting) of the retinal pigment epithelium observed on fundoscopy or fundus imaging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007727 ; owl:annotatedTarget "Lack of transparency of the corneal epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007728 ; owl:annotatedTarget "Abnormal (non-physiological) constriction of the pupil of congenital onset." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:18982377" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007730 ; owl:annotatedTarget "An abnormal reduction in the amount of pigmentation of the iris." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007730 ; owl:annotatedTarget "Light eye color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007730 ; owl:annotatedTarget "Light eye colour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:19468063" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:19838949" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007731 ; owl:annotatedTarget "Abnormal development of the choroid and retina." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007732 ; owl:annotatedTarget "Underdevelopment of the lacrimal gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007732 ; owl:annotatedTarget "Underdeveloped tear gland" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:26884207" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007734 ; owl:annotatedTarget "Abnormally big lacrimal glands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007734 ; owl:annotatedTarget "Enlarged tear gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007737 ; owl:annotatedTarget "Pigment migration into the retina in a bone-spicule configuration (resembling the nucleated cells within the lacuna of bone)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007737 ; owl:annotatedTarget "Retinal 'bone corpuscle' pigmentation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007740 ; owl:annotatedTarget "Long eyelashes in irregular rows" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "PMID:7763343" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007750 ; owl:annotatedTarget "Underdevelopment of the fovea centralis." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Reaxys:608585" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007754 ; owl:annotatedTarget "Macular dystrophy is a nonspecific term for premature retinal cell aging and cell death, generally confied to the macula in which no clear extrinsic cause is evident." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Octadecanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007759 ; owl:annotatedTarget "Reduced transparency of the stroma of cornea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007759 ; owl:annotatedTarget "Cloudy corneas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007761 ; owl:annotatedTarget "A scotoma (area of diminished vision within the visual field) that surrounds the central fixation point." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "octadecanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007763 ; owl:annotatedTarget "Dilatation of small blood vessels of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007765 ; owl:annotatedTarget "Increased depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is increased." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "18:0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007766 ; owl:annotatedTarget "Underdevelopment of the optic disc, that is of the optic nerve head, where ganglion cell axons exit the eye to form the optic nerve." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007766 ; owl:annotatedTarget "Hypoplastic optic discs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007768 ; owl:annotatedTarget "The presence of an increased number of twists and turns of retinal blood vessels (arteries, arterioles, veins, venules)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "C18:0" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007770 ; owl:annotatedTarget "Underdeveloped retina" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "CH3-[CH2]16-COOH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007772 ; owl:annotatedTarget "An impairment of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007772 ; owl:annotatedTarget "Abnormality of visual tracking" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007772 ; owl:annotatedTarget "Impairment of visual pursuit" . [] oboInOwl:hasDbXref , , "PMID:18179896" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007773 ; owl:annotatedTarget "Ocular abnormality characterised by premature degeneration of the vitreous and the retina that may be associated with increased risk of retinal detachment." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "Beilstein:3587721" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Octadecansaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007774 ; owl:annotatedTarget "Underdevelopment of the ciliary body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Oktadekansaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007776 ; owl:annotatedTarget "Hypotrichosis of lower eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007776 ; owl:annotatedTarget "Scanty lower eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007776 ; owl:annotatedTarget "Sparse lower eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007776 ; owl:annotatedTarget "Thin lower eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007778 ; owl:annotatedTarget "A type of retinal neovascularization that affects the posterior pole of the retina." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "STEARIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007780 ; owl:annotatedTarget "A type of cataract characterized by punctate, dust-like opacities within the cortical region of the lens." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "Stearinsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007787 ; owl:annotatedTarget "A type of cataract affecting the posterior pole of lens immediately adjacent to ('beneath') the Lens capsule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007787 ; owl:annotatedTarget "Posterior subcapsular cataracts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007793 ; owl:annotatedTarget "Mottled (spotted or blotched with different shades) pigmentary abnormality of the macula lutea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007795 ; owl:annotatedTarget "A cataract that affects the anterior part of the cortex of the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007799 ; owl:annotatedTarget "The presence of whitish deposits in the conjunctiva resembling salt. May be related to calcinosis." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007800 ; owl:annotatedTarget "Abnormal largeness of the eye with an axial length > 2.5 standard deviations from population mean." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007800 ; owl:annotatedTarget "Increased front to back length of eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007802 ; owl:annotatedTarget "The presence of central, fine, whitish granular lesions in the stroma of the cornea. This type of corneal dystrophy is usually asymptomatic and begins in childhood and shows a slow progression. Later in the course, the corneal epithelium and Bowman's layer may be affected. Histologically, the cornea shows a uniform deposition of hyaline material." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "acide octadecanoique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007803 ; owl:annotatedTarget "Complete color blindness, a complete inability to distinguish colors. Affected persons cannot perceive colors, but only shades of gray." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007803 ; owl:annotatedTarget "Total colorblindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007811 ; owl:annotatedTarget "Nystagmus consisting of horizontal to-and-fro eye movements of equal velocity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "acide stearique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007812 ; owl:annotatedTarget "The presence of one or more dendritic corneal epithelial ulcers characterized by a treelike branching linear pattern with feathery edges and terminal bulbs. Herpetiform corneal ulcers can be identified by fluorescein staining." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007813 ; owl:annotatedTarget "A form of uveitis that is not associated with the formation of granulomas." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007814 ; owl:annotatedTarget "Mottling (spots or blotches with different shades) of the retinal pigment epithelium, i.e., localized or generalized fundal pigment granularity associated with processes at the level of the retinal pigment epithelium." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007814 ; owl:annotatedTarget "RPE irregularity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007814 ; owl:annotatedTarget "RPE mottling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007817 ; owl:annotatedTarget "A supranuclear gaze palsy is an inability to look in a horizontal direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007818 ; owl:annotatedTarget "The presence of distinct colors in the central (pupillary) zone of the iris than in the mid-peripheral (ciliary) zone." . [] oboInOwl:hasDbXref , "PMID:17030721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007819 ; owl:annotatedTarget "Presenile cataract is a kind of cataract that occurs in early adulthood, that is, at an age that is younger than usual." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "n-octadecanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007820 ; owl:annotatedTarget "Congenital absence or closure of the opening of the lacrimal punctum." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007820 ; owl:annotatedTarget "Atretic lacrimal puncta" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007824 ; owl:annotatedTarget "Paralysis of both the extrinsic and intrinsic ocular muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007830 ; owl:annotatedTarget "Inability to see well at night or in poor light with onset in adulthood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007830 ; owl:annotatedTarget "Adult-onset night blindness" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "octadecoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007831 ; owl:annotatedTarget "Nonprogressive restriction of movement of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28842 ; owl:annotatedTarget "stearic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0007832 ; owl:annotatedTarget "Pigmentation of the outer white part of the eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007834 ; owl:annotatedTarget "A kind of cataract that progresses with age." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007835 ; owl:annotatedTarget "S-shaped eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007835 ; owl:annotatedTarget "S-shaped opening between the eyelids" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "CAS:57-60-3" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "PMID:18628202" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007838 ; owl:annotatedTarget "A progressive form of ptosis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007838 ; owl:annotatedTarget "Progressive drooping of upper eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007840 ; owl:annotatedTarget "Increased length of the upper eyelashes." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "Fatty acid anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007840 ; owl:annotatedTarget "Increased length of upper eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007840 ; owl:annotatedTarget "Long upper eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007841 ; owl:annotatedTarget "Deposition of hyaline extracellular material (amyloid) into the vitreous humor, which can manifest as vitreous opacities and reduced visual acuity." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007841 ; owl:annotatedTarget "Amyloid deposition in the vitreous humour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007843 ; owl:annotatedTarget "Narrowing of blood vessels in back of eye" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "Alkanate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "Fettsaeureanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007856 ; owl:annotatedTarget "Punctate opacification (reduced transparency) of the corneal stroma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007858 ; owl:annotatedTarget "Punched out lesions in the pigmented layer of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007859 ; owl:annotatedTarget "Horizontal nystagmus dating from or present at birth." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "Fettsaeureanionen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007862 ; owl:annotatedTarget "Deposition of calcium salts in the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007867 ; owl:annotatedTarget "Fibrosis of only some of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007872 ; owl:annotatedTarget "The presence of multiple hemangiomas in the choroid. These are generally reddish or orange or can have increased pigmentation maiking them difficult to distinguish from choroidal melanomas." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "a fatty acid" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007874 ; owl:annotatedTarget "A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007874 ; owl:annotatedTarget "Almond shaped eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007874 ; owl:annotatedTarget "Almond-shaped opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007875 ; owl:annotatedTarget "Blindness with onset at birth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007875 ; owl:annotatedTarget "Blindness present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007879 ; owl:annotatedTarget "Allergic Conjunctivitis is an allergic inflammation of the conjunctiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007885 ; owl:annotatedTarget "An abnormally slow velocity of horizontal saccadic eye movements." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "acido graso anionico" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007886 ; owl:annotatedTarget "Congenital absence of the extraocular muscles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007886 ; owl:annotatedTarget "Missing eye muscles" . [] oboInOwl:hasDbXref , "PMID:7826272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007889 ; owl:annotatedTarget "A type of posterior subcapsular cataract characterized by an iridescent color." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "acidos grasos anionicos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007892 ; owl:annotatedTarget "Underdevelopment of the lacrimal puncta." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007892 ; owl:annotatedTarget "Hypoplasia of the lacrimal puncta" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007892 ; owl:annotatedTarget "Hypoplastic lacrimal puncta" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "anion de l'acide gras" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007894 ; owl:annotatedTarget "Reduced pigmentation of the fundus, typically generalised. Fundoscopy may reveal a low level pigment in both RPE and choroid with clear visibility of choroidal vessels (pale/albinoid) or low pigment level in the RPE with deep pigment in choroid so that visible choroidal vessels are separated by deeply pigmented zones (tesselated/tigroid)." . [] oboInOwl:hasDbXref , "PMID:21441919" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007899 ; owl:annotatedTarget "Failure of attachment of the retina during development." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28868 ; owl:annotatedTarget "fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007900 ; owl:annotatedTarget "Underdeveloped tear duct" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "Gmelin:2502" . [] oboInOwl:hasDbXref , "PMID:16882398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007902 ; owl:annotatedTarget "Bleeding within the vitreous compartment of the eye." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007902 ; owl:annotatedTarget "Vitreous haemorrhage" . [] oboInOwl:hasDbXref , "PMID:15623792" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007903 ; owl:annotatedTarget "Chorioretinal atrophy along the retinal veins." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007905 ; owl:annotatedTarget "Abnormality of iris blood vessels" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007906 ; owl:annotatedTarget "Elevated IOP" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007906 ; owl:annotatedTarget "High eye pressure" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007906 ; owl:annotatedTarget "Increased IOP" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007906 ; owl:annotatedTarget "Raised IOP" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007911 ; owl:annotatedTarget "Congenital drooping of both upper eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007915 ; owl:annotatedTarget "This corneal dystrophy affects the posterior limiting membrane of the cornea and is characterized by polymorphous plaques of calcium deposits in the deep stromal layers of the cornea, and occasionally by vesicular lesions of the endothelium and edema of the deep corneal stroma." . [] oboInOwl:hasDbXref , "ISBN-13:978-0199679980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007917 ; owl:annotatedTarget "A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes. It is usually seen in the context of diseases that induce a fibrovascular response, e.g. diabetes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007922 ; owl:annotatedTarget "Hypermyelinated retinal nerve fibres" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007924 ; owl:annotatedTarget "Slow decrease in sharpness of vision" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007924 ; owl:annotatedTarget "Decreased visual acuity, slowly progressive" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007925 ; owl:annotatedTarget "A congenital defect resulting in absence of the lacrimal duct." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007925 ; owl:annotatedTarget "Absent tear duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007928 ; owl:annotatedTarget "Anomaly of the visual evoked potentials elicited by a flash stimulus, generally a flash of light subtending an angle of at least 20 degrees of the visual field and presented in a dimly lit room." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007932 ; owl:annotatedTarget "Congenital abnormal dilation of the pupil on both sides." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Beilstein:508624" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007933 ; owl:annotatedTarget "Regional increase in the width (height) of the lateral eyebrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007933 ; owl:annotatedTarget "Wide lateral eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007936 ; owl:annotatedTarget "Fibrosis of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:fprobst", "PMID:28114409" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007937 ; owl:annotatedTarget "A type of retinal reticular pigmentation that forms a polygonal, netlike arrangement of hyperpigmented lines forming geometric patterns in the fundus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007939 ; owl:annotatedTarget "A form of monochromacy in which vision is derived from the remaining preserved blue (S) cones and rod photoreceptors." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "CAS:544-63-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007942 ; owl:annotatedTarget "Paralysis of the iris and ciliary apparatus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007943 ; owl:annotatedTarget "A form of stapes ankylosis with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007946 ; owl:annotatedTarget "A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures on one side only." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007946 ; owl:annotatedTarget "Unequal size of opening between the eyelids" . [] oboInOwl:hasDbXref , "PMID:28981474" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007947 ; owl:annotatedTarget "A subtype of retinitis pigmentosa in which, instead of the pathology starting in the mid-periphery like typical retinitis pigmentosa, the disease starts in the near periphery closer to the vascular arcades and tends to spare the far periphery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007948 ; owl:annotatedTarget "A type of posterior cortical cataract characterized by dense lenticular opacities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007950 ; owl:annotatedTarget "Chorioretinal atrophy concentrated around the optic papilla (i.e., the optic nerve head)." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "CAS:544-63-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007957 ; owl:annotatedTarget "A reduction of corneal clarity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007963 ; owl:annotatedTarget "A spectrum of fundoscopic appearances characterized by the development of a variety of patterns of deposits predominantly in the macular area. The deposits are typically bilateral, relatively symmetrical, yellow/white and associated with changes at the level of the retinal pigment epithelium. With time, retinal atrophy may occur. A number of pattern dystrophy subtypes have been described including butterfly-shaped dystrophy, reticular dystrophy (net-like pattern) and fundus pulverulentus (granular, mottled pigmentation)." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "CAS:544-63-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007968 ; owl:annotatedTarget "Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth. This features results from a failure of regression of the hyaloid vessel, which supplies the primary vitreous during embryogenesis and normally regresses in the third trimester of pregnancy, leading to a particular form of posterior cataract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007968 ; owl:annotatedTarget "Persistent fetal vasculature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007968 ; owl:annotatedTarget "Persistent foetal vasculature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007968 ; owl:annotatedTarget "Persistent posterior foetal fibrovascular sheath of the lens" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007970 ; owl:annotatedTarget "Congenital drooping upper eyelid" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Gmelin:242115" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007971 ; owl:annotatedTarget "A congenital cataract in which opacity is limited to layers of the lens external to the nucleus (i.e., the perinuclear region), i.e., between the nuclear and cortical layers of the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007973 ; owl:annotatedTarget "The presence of developmental dysplasia of the retina." . [] oboInOwl:hasDbXref , "PMID:572501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007975 ; owl:annotatedTarget "Saccadic undershoot of horizontal saccadic eye movements, i.e., a horizontal saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010014" . [] oboInOwl:hasDbXref , "PMID:19496508", "PMID:9158139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007976 ; owl:annotatedTarget "Cerulean cataracts are a kind of congenital cataract having peripheral bluish and white opacifications in concentric layers with occasional central lesions arranged radially. Although the opacities may be observed during fetal development and childhood, usually visual acuity is only mildly reduced until adulthood, when lens extraction is generally necessary." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007979 ; owl:annotatedTarget "Horizontal nystagmus made apparent by looking to the right or to the left." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007979 ; owl:annotatedTarget "Nystagmus, horizontal gaze-evoked" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:13129458" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007984 ; owl:annotatedTarget "A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave (source: Holder GE., Inherited Chorioretinal Dystrophies: A Textbook and Atlas; 2014; p.17; ISBN 978-3-540-69466-3)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007984 ; owl:annotatedTarget "Electronegative ERG" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007985 ; owl:annotatedTarget "Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007985 ; owl:annotatedTarget "Blocked retinal artery" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:15149689" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007988 ; owl:annotatedTarget "Decreased amount of pigmentation in the macula lutea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007989 ; owl:annotatedTarget "Retinal exudate within the retinal tissue itself." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:16509590" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007990 ; owl:annotatedTarget "Underdevelopment of the stroma of iris." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007990 ; owl:annotatedTarget "Underdeveloped iris stroma" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:16554156" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007993 ; owl:annotatedTarget "Congenital malformation of the lacrimal duct associated with incomplete development of the bony nasolacrimal canal or craniofacial anomalies." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007993 ; owl:annotatedTarget "Malformed tear ducts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0007994 ; owl:annotatedTarget "Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007994 ; owl:annotatedTarget "Kalnienk vision" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0007994 ; owl:annotatedTarget "Loss of peripheral vision" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0007994 ; owl:annotatedTarget "Tunnel vision" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:19154695" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:19761868" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008000 ; owl:annotatedTarget "An abnormally reduced response to stimulation of the cornea (by touch, foreign body, blowing air). The corneal reflex (also known as the blink reflex, normally results in an involuntary blinking of the eyelids." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:19786012" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008001 ; owl:annotatedTarget "Increased amount of pigmentation in the fovea centralis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:19902021" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008002 ; owl:annotatedTarget "Abnormality of macular or foveal pigmentation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008009 ; owl:annotatedTarget "Three rows of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008009 ; owl:annotatedTarget "Triple row of eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008011 ; owl:annotatedTarget "Reduced transparency of the peripheral region of the cornea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008014 ; owl:annotatedTarget "Microscopic aneurysms of the retinal arterioles near the central part of the fundus, visible as small round dark red dots on the retinal surface (not arising from visible vessels) that are by definition less than the diameter of the major optic veins as they cross the optic disc." . [] oboInOwl:hasDbXref , "PMID:5087595" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008019 ; owl:annotatedTarget "Partial dislocation of the lens in a superior direction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:19955401" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008019 ; owl:annotatedTarget "Superior subluxated lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008028 ; owl:annotatedTarget "A form of macular degeneration characterized by the presence of multiple cysts in the macula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008031 ; owl:annotatedTarget "A type of sutural cataract in which the opacity follows the posterior Y suture." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:21603897" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:20634506" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008034 ; owl:annotatedTarget "Abnormal pigmentation of the iris." . [] oboInOwl:hasDbXref , "PMID:9734800" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008035 ; owl:annotatedTarget "Retinitis pigmentosa inversa is form of retinal degeneration characterized by areas of retinal/chorioretinal degeneration with pigment migration in the macular area (in contrast to retinitis pigmentosa which, at early disease stages, predominantly affects the retinal periphery)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:20920594" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008038 ; owl:annotatedTarget "Absence or underdevelopment of the lacrimal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008038 ; owl:annotatedTarget "Absent/underdeveloped lacrimal glands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008038 ; owl:annotatedTarget "Absent/underdeveloped tear glands" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:21955528" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008043 ; owl:annotatedTarget "Decreased retinal arteriolar diameters, which may decrease blood flow and slow oxygen delivery to regions of the retina." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:22030224" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008046 ; owl:annotatedTarget "A structural abnormality of retinal vasculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008046 ; owl:annotatedTarget "Abnormality of retina blood vessels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:27206979" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008047 ; owl:annotatedTarget "Abnormality of eye blood vessels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:28600633" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008048 ; owl:annotatedTarget "An abnormality of the line of Schwalbe." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "PMID:6802973" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008049 ; owl:annotatedTarget "An abnormality of an extraocular muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008050 ; owl:annotatedTarget "An anomaly of the space between the medial and lateral canthi of the two open eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008050 ; owl:annotatedTarget "Abnormality of the opening between the eyelids" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Reaxys:508624" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008050 ; owl:annotatedTarget "Abnormality of the palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0008050 ; owl:annotatedTarget "Deformity of the palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0008050 ; owl:annotatedTarget "Malformation of the palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008052 ; owl:annotatedTarget "A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008052 ; owl:annotatedTarget "Retinal folds" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Tetradecanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008053 ; owl:annotatedTarget "Absence or underdevelopment of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008053 ; owl:annotatedTarget "Absent/small iris" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008053 ; owl:annotatedTarget "Absent/underdeveloped iris" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "myristic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008054 ; owl:annotatedTarget "Any abnormality of the blood vessels of the conjunctiva." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:21823181" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "1-tetradecanecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008055 ; owl:annotatedTarget "Absence or underdevelopment of the uvea, the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008055 ; owl:annotatedTarget "Absent/underdeveloped uvea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "14" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008056 ; owl:annotatedTarget "Absent/small eye" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008056 ; owl:annotatedTarget "Absent/underdeveloped eye" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "14:0" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/febrile_seizure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008057 ; owl:annotatedTarget "Absent/small fundus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "14:00" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008058 ; owl:annotatedTarget "Absent/small optic nerve" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008058 ; owl:annotatedTarget "Absent/underdeveloped optic nerve" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008059 ; owl:annotatedTarget "Absent/underdeveloped macula" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "C14" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008060 ; owl:annotatedTarget "Congenital absence or underdevelopment of the fovea centralis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008060 ; owl:annotatedTarget "Absent/underdeveloped fovea" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "CH3-[CH2]12-COOH" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008061 ; owl:annotatedTarget "Absent/small retina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008061 ; owl:annotatedTarget "Absent/underdeveloped retina" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "MYRISTIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008062 ; owl:annotatedTarget "Absence or underdevelopment of the anterior segment of the eye." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Myristic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008063 ; owl:annotatedTarget "Absence or underdevelopment of the lens." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008063 ; owl:annotatedTarget "Absent/small lens" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008063 ; owl:annotatedTarget "Absent/underdeveloped lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008064 ; owl:annotatedTarget "An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization." . [] a owl:Axiom ; rdfs:label "Ichthyosis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0008064 ; owl:annotatedTarget "MEDDRA:10021198" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "Myristinsaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008065 ; owl:annotatedTarget "Absent/small skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008065 ; owl:annotatedTarget "Absent/underdeveloped skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "acide tetradecanoique" . [] oboInOwl:hasDbXref , "PMID:31596619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "Abnormal blistering of the skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "Blistering, generalised" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "Blistering, generalized" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "Blisters" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008066 ; owl:annotatedTarget "Skin blisters" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:21854850" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "n-Tetradecan-1-oic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008067 ; owl:annotatedTarget "Abnormally loose or hyperelastic skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008067 ; owl:annotatedTarget "Abnormally loose or stretchable skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Skin cancer (non-melanoma)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Dermatological tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Dermatological tumours" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Skin tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Skin tumours" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Tumor of the skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Tumour of the skin" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "n-Tetradecoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008069 ; owl:annotatedTarget "Skin cancer" . [] oboInOwl:hasDbXref , "PMID:14676077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008070 ; owl:annotatedTarget "Reduced density of hairs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008070 ; owl:annotatedTarget "Sparse hair" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "n-tetradecanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008070 ; owl:annotatedTarget "Thin, sparse hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008071 ; owl:annotatedTarget "Increased blood pressure during a pregnancy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008072 ; owl:annotatedTarget "Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum." . [] oboInOwl:hasDbXref "PMID:19038077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008073 ; owl:annotatedTarget "An abnormally low concentration of serum conjugated estriol as compared to normal values for gestational-age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008073 ; owl:annotatedTarget "Low maternal serum estriol" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28875 ; owl:annotatedTarget "tetradecoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008076 ; owl:annotatedTarget "Reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "LIPID_MAPS_class:LMSP0601" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008079 ; owl:annotatedTarget "A developmental abnormality characterized by the absence of the fifth metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008079 ; owl:annotatedTarget "Absent 5th long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008080 ; owl:annotatedTarget "Medial deviation of the great toe owing to a deformity of the great toe joint causing the hallux to deviate medially." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "PMID:16158191" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008083 ; owl:annotatedTarget "Underdeveloped 2nd-5th middle toe bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "PMID:2088646" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "Ganglioside" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008087 ; owl:annotatedTarget "The presence of a fifth metatarsal bone that has not undergone ossification at an age when ossification is usually visible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008089 ; owl:annotatedTarget "An anomaly of the fifth metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008089 ; owl:annotatedTarget "Abnormality of the 5th long bone of foot" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "sialoglycosphingolipids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008093 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the fourth toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008093 ; owl:annotatedTarget "Short 4th toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008093 ; owl:annotatedTarget "Short fourth toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "gangliosides" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008094 ; owl:annotatedTarget "An overall widening of the spaces between the digits." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008094 ; owl:annotatedTarget "Widely spaced toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22006570" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28892 ; owl:annotatedTarget "gangliosides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008095 ; owl:annotatedTarget "Osteolysis affecting the talus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008096 ; owl:annotatedTarget "Medial deviation of the second toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008103 ; owl:annotatedTarget "Delayed maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008103 ; owl:annotatedTarget "Delayed ankle bone maturation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008107 ; owl:annotatedTarget "The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot located between the first and second toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008108 ; owl:annotatedTarget "Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008108 ; owl:annotatedTarget "Accelerated ankle bone maturation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008111 ; owl:annotatedTarget "Broad distal big toe" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008112 ; owl:annotatedTarget "Plantar flexion contractures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008114 ; owl:annotatedTarget "Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008115 ; owl:annotatedTarget "Bending or curvature of a third toe in the tibial direction (i.e., towards the big toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008115 ; owl:annotatedTarget "Curvature of 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008116 ; owl:annotatedTarget "Limitation of the ability to bend the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008119 ; owl:annotatedTarget "Deformed ankle bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008122 ; owl:annotatedTarget "Synostosis of the calcaneus with the navicular bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008124 ; owl:annotatedTarget "A congenital deformity characterized by a dorsiflexed, inverted, and adducted foot, i.e., a combination of talipes calcaneus and talipes varus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008127 ; owl:annotatedTarget "A two-part calcaneus, a finding that probably results from delayed coalescence of two primary calcaneal centers of ossification." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008127 ; owl:annotatedTarget "Delayed coalescence of calcaneal ossification centres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008127 ; owl:annotatedTarget "Double calcaneal ossification centre" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008127 ; owl:annotatedTarget "Extra calcaneal ossification centre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008131 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22016370" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008134 ; owl:annotatedTarget "Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008134 ; owl:annotatedTarget "Irregular tarsal centres" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008134 ; owl:annotatedTarget "Irregular ankle bone maturation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008138 ; owl:annotatedTarget "Abnormal plantar flexion of the calcaneus relative to the longitudinal axis of the tibia. This results in the angle between the long axis of the tibia and the long axis of the heel bone (calcaneus) being greater than 90 degrees." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008141 ; owl:annotatedTarget "Dislocation of toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008142 ; owl:annotatedTarget "Delayed maturation and calcification of the calcaneus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008142 ; owl:annotatedTarget "Delayed heel bone maturation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008148 ; owl:annotatedTarget "Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008150 ; owl:annotatedTarget "Elevations of the levels of SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) that occur during infections." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Beilstein:2368277" . [] oboInOwl:hasDbXref , "PMID:26351955", "PMID:29939529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008151 ; owl:annotatedTarget "Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008151 ; owl:annotatedTarget "Increased INR" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008151 ; owl:annotatedTarget "Increased international normalised ratio" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008151 ; owl:annotatedTarget "Prolonged PT" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008151 ; owl:annotatedTarget "increased international normalised ratio" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008153 ; owl:annotatedTarget "Episodes of muscle weakness associated with reduced levels of potassium in the blood." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "CAS:51-43-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008155 ; owl:annotatedTarget "Excessive amounts of mucopolysaccharide in the urine." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "CAS:51-43-4" . [] oboInOwl:hasDbXref , "PMID:6579550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008158 ; owl:annotatedTarget "Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008160 ; owl:annotatedTarget "The concentration of 2-hydroxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "CAS:51-43-4" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Drug_Central:1028" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008161 ; owl:annotatedTarget "Alkaline phosphatase levels measured within leukocytes is below detectable levels." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008161 ; owl:annotatedTarget "Absent leukocyte ALP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008162 ; owl:annotatedTarget "An increased concentration of ammonia in the blood not associated with symptoms such as encephalopathy." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:18325983" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008163 ; owl:annotatedTarget "Abnormally reduced concentration of cortisol in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008163 ; owl:annotatedTarget "Low blood cortisol level" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:21963816" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22215378" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22115931" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008165 ; owl:annotatedTarget "Reduced proportion of helper T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008166 ; owl:annotatedTarget "Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22405854" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008169 ; owl:annotatedTarget "Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008179 ; owl:annotatedTarget "An abnormal reduction in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008179 ; owl:annotatedTarget "Decreased Arden ratio of EOG" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22425731" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly elevated CPK" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly elevated creatine phosphokinase" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly elevated serum CK" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly elevated serum CPK" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22429969" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly elevated serum phospho-CK" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Mildly increased serum creatine kinase" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Moderately elevated serum CK" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008180 ; owl:annotatedTarget "Moderately elevated serum CPK" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22569014" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008181 ; owl:annotatedTarget "An absence of low-density lipoprotein cholesterol in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22623754" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008182 ; owl:annotatedTarget "Small adrenal cortex" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22826982" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008185 ; owl:annotatedTarget "The onset of puberty before the age of 9 years in boys." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008185 ; owl:annotatedTarget "Early onset of puberty in males" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008186 ; owl:annotatedTarget "The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008187 ; owl:annotatedTarget "No secondary sexual characteristics are present at puberty." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22895980" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008189 ; owl:annotatedTarget "Decreased sensitivity toward insulin." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22898765" . [] oboInOwl:hasDbXref , "PMID:2918525" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008191 ; owl:annotatedTarget "The congenital absence of the thyroid gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22905594" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008194 ; owl:annotatedTarget "The presence of multiple pancreatic islet cell adenomas." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22311625" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:22940899" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008198 ; owl:annotatedTarget "Deficiency of parathyroid hormone with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008200 ; owl:annotatedTarget "A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia." . [] oboInOwl:hasDbXref , , "PMID:23378139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008202 ; owl:annotatedTarget "A reduced level of prolactin in the blood circulation. Prolactin is a protein hormone that is secreted by lactotrophs in the anterior pituitary and that stimulates mammary gland development and milk production." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:23066296" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008204 ; owl:annotatedTarget "Precocious puberty with Sertoli cell tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008205 ; owl:annotatedTarget "Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008207 ; owl:annotatedTarget "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:23130169" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008208 ; owl:annotatedTarget "Hyperplasia of the parathyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008208 ; owl:annotatedTarget "Enlarged parathyroid glands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008209 ; owl:annotatedTarget "Amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian inssuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008209 ; owl:annotatedTarget "Early menopause" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008209 ; owl:annotatedTarget "Premature menopause" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008209 ; owl:annotatedTarget "Premature ovarian failure" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:23164182" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008211 ; owl:annotatedTarget "Aplasia of the parathyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008213 ; owl:annotatedTarget "A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:23185846" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008214 ; owl:annotatedTarget "Decreased serum estradiol" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "PMID:29438107" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008216 ; owl:annotatedTarget "Abnormal development of the adrenal gland." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Reaxys:2368277" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008221 ; owl:annotatedTarget "Enlargement of the adrenal gland." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008221 ; owl:annotatedTarget "Enlarged adrenal glands" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008222 ; owl:annotatedTarget "Female infertility" . [] oboInOwl:hasDbXref "PMID:28406057" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008223 ; owl:annotatedTarget "Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4)." . [] oboInOwl:hasDbXref "PMID:28406057" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008223 ; owl:annotatedTarget "Subclinical hypothyroidism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008226 ; owl:annotatedTarget "Insufficient amount of androgenic activity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008227 ; owl:annotatedTarget "A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(-)-(R)-epinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008229 ; owl:annotatedTarget "The presence of lymphangiectasis of the thyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008232 ; owl:annotatedTarget "An elevated concentration of follicle-stimulating hormone in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008232 ; owl:annotatedTarget "Elevated FSH level" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22451307" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(-)-adrenaline" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008233 ; owl:annotatedTarget "Decreased serum progesterone" . [] oboInOwl:hasDbXref , "PMID:18731015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008237 ; owl:annotatedTarget "A type of hypothyroidism that results from a defect in thyrotropin-releasing hormone activity." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(R)-(-)-Adnephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008239 ; owl:annotatedTarget "Developmental hypoplasia of the adrenal medulla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008239 ; owl:annotatedTarget "Small adrenal medulla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008242 ; owl:annotatedTarget "A state of renal tubular unresponsiveness or resistance to the action of aldosterone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008244 ; owl:annotatedTarget "A type of adrenal hypoplasia with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008245 ; owl:annotatedTarget "A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008245 ; owl:annotatedTarget "Low thyroid gland function due to abnormal pituitary gland" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(R)-(-)-Adrenaline" . [] oboInOwl:hasDbXref , "eMedicine:118562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008247 ; owl:annotatedTarget "Increased levels of thyroxine without evidence of clinical thyroid disease." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(R)-(-)-Epinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008249 ; owl:annotatedTarget "Hyperplasia of the thyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008249 ; owl:annotatedTarget "Large thyroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008251 ; owl:annotatedTarget "An enlargement of the thyroid gland with congenital onset." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008251 ; owl:annotatedTarget "Congenital goitre" . [] oboInOwl:hasDbXref , "PMID:17287480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008256 ; owl:annotatedTarget "Adrenocortical adenomas are benign tumors of the adrenal cortex." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(R)-(-)-Epirenamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008258 ; owl:annotatedTarget "A type of adrenal hyperplasia with congenital onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008259 ; owl:annotatedTarget "Adrenal insufficiency secondary to a defect in the ACTH receptor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "(R)-(-)-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008261 ; owl:annotatedTarget "The presence of an adenoma of the pancreas with origin in a pancreatic B cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008264 ; owl:annotatedTarget "The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies." . [] oboInOwl:hasDbXref , "PMID:11879535", "PMID:7757081", "PMID:9468540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008271 ; owl:annotatedTarget "Abnormal morphology of collagen fibers in cartilage. In cartilage, collagen II, actually a collagen II:IX:XI heterofibril, is by far the most important type of collagen. A number of abnormalities may be appreciated by electron micrography or biochemical investigations, including sparse collagen fibers in the cartilage matrix." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008277 ; owl:annotatedTarget "An abnormality of zinc ion homeostasis." . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Adrenalin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008278 ; owl:annotatedTarget "Atrophy (wasting) of the cerebellar cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008278 ; owl:annotatedTarget "Cerebellar cortex degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008281 ; owl:annotatedTarget "An increased concentration of ammonia in the blood with sudden onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008282 ; owl:annotatedTarget "An increased amount of unconjugated (indirect) bilurubin in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008283 ; owl:annotatedTarget "An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008283 ; owl:annotatedTarget "High blood insulin levels while fasting" . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008290 ; owl:annotatedTarget "A partial reduction in level of the complement component Factor H in circulation." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008291 ; owl:annotatedTarget "A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008293 ; owl:annotatedTarget "An increase in the level of long-chain dicarboxylic acid in the urine." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Adrenalin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008297 ; owl:annotatedTarget "A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Epinephrin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008301 ; owl:annotatedTarget "An increased concentration of dermatan sulfate in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008301 ; owl:annotatedTarget "Dermatan sulphate excretion in urine" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "PMID:22458763" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Epipen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008303 ; owl:annotatedTarget "Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008305 ; owl:annotatedTarget "Presence of myoglobin in the urine following exercise." . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Epipen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008309 ; owl:annotatedTarget "An increase in the level of medium chain dicarboxylic acid in the urine." . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Epipen JR" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008314 ; owl:annotatedTarget "A reduction in the activity of the mitochondrial respiratory chain complex II, which is part of the electron transport chain in mitochondria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008315 ; owl:annotatedTarget "A decreased concentration of free (unbound) carnitine in the blood." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "L-Adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008316 ; owl:annotatedTarget "An abnormality of the mitochondria in muscle tissue." . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "Primatene" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008318 ; owl:annotatedTarget "Increased alkaline phosphatase measured within leukocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008318 ; owl:annotatedTarget "Elevated leukocyte ALP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008320 ; owl:annotatedTarget "Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008321 ; owl:annotatedTarget "Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008321 ; owl:annotatedTarget "Decreased factor x activity" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008322 ; owl:annotatedTarget "Any structural anomaly of the mitochondria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008323 ; owl:annotatedTarget "An abnormality of the combined rod-and-cone response on electroretinogram." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008326 ; owl:annotatedTarget "Reduced vitamin b6 levels" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008326 ; owl:annotatedTarget "Vitamin B6 deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008327 ; owl:annotatedTarget "The presence of microscopic crystalline calcium precipitates in the form of oxalate and/or phosphate in the renal parenchyma." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "epinefrina" . [] oboInOwl:hasDbXref , "PMID:19694940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008330 ; owl:annotatedTarget "Decreased activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008330 ; owl:annotatedTarget "Decreased von willebrand factor activity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Elevated CK after exercise" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Elevated CPK after exercise" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/creatine_kinase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Elevated creatine phosphokinase after exercise" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Elevated phospho-CK after exercise" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/creatine_kinase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Elevated phospho-creatine kinase after exercise" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Increased CK after exercise" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Increased creatine kinase after exercise" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Increased creatine phosphokinase after exercise" . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "epinephrine" . [] oboInOwl:hasDbXref hp:abbreviation, ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Increased phospho-CK after exercise" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008331 ; owl:annotatedTarget "Increased phospho-creatine kinase after exercise" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/Factor_D" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008338 ; owl:annotatedTarget "Partial functional adipsin deficiency" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/factor_d" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008338 ; owl:annotatedTarget "Partial functional factor d deficiency" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "epinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008341 ; owl:annotatedTarget "A type of renal tubular acidosis characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. The urine cannot be acidified below a pH of 5.3, associated with acidemia and hypokalemia." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "Reaxys:3587721" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "epinephrinum" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008344 ; owl:annotatedTarget "Concentration of a branched chain amino acid in the blood above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008345 ; owl:annotatedTarget "Underdevelopment of the dilatator pupillae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008345 ; owl:annotatedTarget "Hypoplasia of the pupil dilator muscle" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28918 ; owl:annotatedTarget "levoepinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008345 ; owl:annotatedTarget "Underdeveloped iris dilator muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008345 ; owl:annotatedTarget "Underdeveloped pupil dilator muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008346 ; owl:annotatedTarget "Increased sickling of erythrocytes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008346 ; owl:annotatedTarget "Increased sickling of red cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008347 ; owl:annotatedTarget "A reduction in the activity of the mitochondrial respiratory chain complex IV, which is part of the electron transport chain in mitochondria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008348 ; owl:annotatedTarget "A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008352 ; owl:annotatedTarget "An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008352 ; owl:annotatedTarget "Impaired thrombocytes adhesion" . [] oboInOwl:hasDbXref "PMID:30177408" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008353 ; owl:annotatedTarget "The presence of an abnormally increased concentration of neutral amino acids in the urine. The neutral amino acids are tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008354 ; owl:annotatedTarget "Reduced ability to transform factor X into its activated form factor Xa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008357 ; owl:annotatedTarget "Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008358 ; owl:annotatedTarget "An increased concentration of proline in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008358 ; owl:annotatedTarget "Prolinemia" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008360 ; owl:annotatedTarget "A neonatal decreased concentration of proteins in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008362 ; owl:annotatedTarget "Absence or underdevelopment of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008362 ; owl:annotatedTarget "Absent/small big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008362 ; owl:annotatedTarget "Absent/underdeveloped big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008363 ; owl:annotatedTarget "Absence or underdevelopment of the tarsal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008363 ; owl:annotatedTarget "Absent/small ankle bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008363 ; owl:annotatedTarget "Absent/underdeveloped ankle bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008364 ; owl:annotatedTarget "An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008364 ; owl:annotatedTarget "Abnormal heel bone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "CAS:14798-03-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008365 ; owl:annotatedTarget "An abnormality of the talus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008365 ; owl:annotatedTarget "Abnormal large bone of ankle" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "CAS:14798-03-9" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008366 ; owl:annotatedTarget "Contractures of the foot joints" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "Gmelin:84" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008368 ; owl:annotatedTarget "Synostosis (bony fusion) involving one or more bones of the tarsus (calcaneus, talus, cuboid, navicular, cuneiiform bones)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008368 ; owl:annotatedTarget "Fused ankle bones" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "UM-BBD_compID:c0159" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:11319011" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008369 ; owl:annotatedTarget "An abnormality of the formation and mineralization of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008369 ; owl:annotatedTarget "Hardening of ankle bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008369 ; owl:annotatedTarget "Abnormal maturation of ankle bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:11341317" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008371 ; owl:annotatedTarget "Any abnormal process of ossification of the metatarsal bones, which normally are each ossified from two centers: one for the body, and one for the head (metatarsal II,III,IV, and V) and one for the body and one for the base (metatarsal I). The ossification process begins in the center of the body about the ninth week, and extends toward either extremity. The center for the base of the first metatarsal appears about the third year, and the centers for the heads of the other bones between the fifth and eighth years. They join the bodies between the eighteenth and twentieth years." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008371 ; owl:annotatedTarget "Abnormal maturation of long bone of foot" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:12096804" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008373 ; owl:annotatedTarget "Puberty and gonadal disorders" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008376 ; owl:annotatedTarget "Breathy speech" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:14512268" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008383 ; owl:annotatedTarget "Nails whose growth is slower than normal." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:14879753" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008383 ; owl:annotatedTarget "Slow-growing nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008386 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the nail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008386 ; owl:annotatedTarget "Absent/small nails" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:16345391" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008386 ; owl:annotatedTarget "Absent/underdeveloped nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008388 ; owl:annotatedTarget "An anomaly of the toenail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008388 ; owl:annotatedTarget "Abnormality of the toenail" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:16903292" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008388 ; owl:annotatedTarget "Abnormality of the toenails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008390 ; owl:annotatedTarget "Repeated loss, or shedding, of the nails of the fingers and toes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008390 ; owl:annotatedTarget "Recurrent loss of toenails and fingernails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008390 ; owl:annotatedTarget "Recurrent shedding of toenails and fingernails" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:17392693" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008391 ; owl:annotatedTarget "The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate." . [] oboInOwl:hasDbXref , "http://naildystrophy.com/" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008391 ; owl:annotatedTarget "Poor fingernail formation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008392 ; owl:annotatedTarget "A thickening of the stratum corneum in the region beneath the nails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008392 ; owl:annotatedTarget "Thickened, discolored skin under nail" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008392 ; owl:annotatedTarget "Thickened, discoloured skin under nail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008394 ; owl:annotatedTarget "Congenital malformed nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008396 ; owl:annotatedTarget "Chronic infection of the nails by Candida species." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:18515490" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008398 ; owl:annotatedTarget "A nail of the fifth finger that is diminished in length and width, i.e., underdeveloped nail of little finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008398 ; owl:annotatedTarget "Underdeveloped fifth fingernail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008398 ; owl:annotatedTarget "Underdeveloped fingernail of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008398 ; owl:annotatedTarget "Underdeveloped fingernail of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008398 ; owl:annotatedTarget "Underdeveloped fingernail of pinky finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:19199063" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008399 ; owl:annotatedTarget "A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008399 ; owl:annotatedTarget "Thick skin around nails" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008400 ; owl:annotatedTarget "Detachment of the distal fingernails from the nail bed." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008400 ; owl:annotatedTarget "Detachment of outermost fingernails" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "2-oxopropanoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:19596600" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008401 ; owl:annotatedTarget "Thickened toenails." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008401 ; owl:annotatedTarget "Overgrowth and curving of toenails" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008402 ; owl:annotatedTarget "Longitudinal, linear prominences in the fingernail plate." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008402 ; owl:annotatedTarget "Longitudinally grooved fingernails" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008402 ; owl:annotatedTarget "Ridged fingernail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008402 ; owl:annotatedTarget "Ridged fingernails" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:19682559" . [] oboInOwl:hasDbXref "PMID:19675700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008404 ; owl:annotatedTarget "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate." . [] a owl:Axiom ; rdfs:label "Nail dystrophy" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0008404 ; owl:annotatedTarget "MEDDRA:10028698" . [] oboInOwl:hasDbXref , "http://naildystrophy.com/" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008404 ; owl:annotatedTarget "Poor nail formation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008407 ; owl:annotatedTarget "Tightly curved thumb nail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008414 ; owl:annotatedTarget "Hunched back in infancy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008414 ; owl:annotatedTarget "Round back in infancy" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:19716251" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008417 ; owl:annotatedTarget "Small, underdeveloped vertebral bodies." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008417 ; owl:annotatedTarget "Underdeveloped vertebrae" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:21993530" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008419 ; owl:annotatedTarget "The presence of degenerative changes of intervertebral disk." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008419 ; owl:annotatedTarget "Degeneration of intervertebral discs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008419 ; owl:annotatedTarget "Degenerative disc disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008419 ; owl:annotatedTarget "Degenerative intervertebral disc" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:22265469" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008420 ; owl:annotatedTarget "The presence of punctiform calcification of the bone of the vertebral bodies." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:22524020" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:22562341" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008422 ; owl:annotatedTarget "An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008422 ; owl:annotatedTarget "Wedge-shaped vertebrae" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "PMID:22631217" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008423 ; owl:annotatedTarget "The presence of developmental dysplasia of the vertebral column." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "Reaxys:16093784" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008424 ; owl:annotatedTarget "Underdeveloped 5th lumbar vertebrae" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "ammonium" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "pyruvate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "ammonium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008428 ; owl:annotatedTarget "Schisis (cleft or cleavage) of vertebral bodies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008430 ; owl:annotatedTarget "Anterior tongue-like protrusions of the vertebral bodies of the lumbar spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008432 ; owl:annotatedTarget "An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "azanium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008434 ; owl:annotatedTarget "Underdeveloped cervical vertebrae" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "Ammonium(1+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008436 ; owl:annotatedTarget "Absent/small tailbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008436 ; owl:annotatedTarget "Absent/underdeveloped tailbone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "NH4(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008438 ; owl:annotatedTarget "A morphological abnormality of the vertebral arch, i.e., of the posterior part of a vertebra." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "NH4(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008439 ; owl:annotatedTarget "Absence of one half of the vertebral body in the lumbar spine." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "NH4+" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008440 ; owl:annotatedTarget "Any abnormality of the atlas and the axis." . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "[NH4](+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008441 ; owl:annotatedTarget "The presence of one or more herniated nucleus pulposus of intervertebral disk." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008441 ; owl:annotatedTarget "Herniated disc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008441 ; owl:annotatedTarget "Herniated disk" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "ammonium cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008442 ; owl:annotatedTarget "Excessive growth of the bones of the vertebral bodies." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28938 ; owl:annotatedTarget "ammonium ion" . [] oboInOwl:hasDbXref "PMID:29755231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008443 ; owl:annotatedTarget "A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008444 ; owl:annotatedTarget "An abnormality of the shape of vertebrae, such that they are wedge-shaped (narrow towards the back)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008445 ; owl:annotatedTarget "An abnormal narrowing of the cervical spinal canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008450 ; owl:annotatedTarget "A reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "2-oxopropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008454 ; owl:annotatedTarget "Over curvature of the lumbar region." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008454 ; owl:annotatedTarget "Rounded lower back" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Beilstein:2339331" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008455 ; owl:annotatedTarget "Absence of some of the sacral and coccygeal bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008456 ; owl:annotatedTarget "A partial dislocation of the intervertebral joint between the second and third cervical vertebrae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008457 ; owl:annotatedTarget "Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008458 ; owl:annotatedTarget "A progressive form of scoliosis with congenital onset." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "CAS:67-97-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008459 ; owl:annotatedTarget "Agenesis of one or more vertebrae of the cervical vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008459 ; owl:annotatedTarget "Missing cervical vertebrae" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "CAS:67-97-0" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008460 ; owl:annotatedTarget "Underdeveloped spinal processes" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "CAS:67-97-0" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Drug_Central:2840" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Gmelin:1267613" . [] oboInOwl:hasDbXref "PMID:26167231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008465 ; owl:annotatedTarget "A developmental defect characterized by agenesis of one or more vertebral bodies." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008465 ; owl:annotatedTarget "Absent vertebrae" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST03020000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008467 ; owl:annotatedTarget "Absence of one half of the vertebral body in the thoracic spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008469 ; owl:annotatedTarget "Dysplasia of the cervical vertebral column." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST03020001" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008470 ; owl:annotatedTarget "A reduction of the distance between the lower thoracic vertebral pedicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008472 ; owl:annotatedTarget "Large tailbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008472 ; owl:annotatedTarget "Prominent protruding tailbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:10347174" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008473 ; owl:annotatedTarget "An abnormal reduction of the anterioposterior diameter of the vertebral body." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15361 ; owl:annotatedTarget "2-oxopropanoic acid, ion(1-)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:11493580" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:12174089" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008477 ; owl:annotatedTarget "Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:12955389" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008479 ; owl:annotatedTarget "Underdeveloped back bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:15214747" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008480 ; owl:annotatedTarget "Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008480 ; owl:annotatedTarget "Cervical osteoarthritis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:15876428" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008480 ; owl:annotatedTarget "Cervical spine degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008480 ; owl:annotatedTarget "Neck arthritis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:16886665" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008484 ; owl:annotatedTarget "A reduction of the distance between thoracolumbar vertebral pedicles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008486 ; owl:annotatedTarget "Narrowing (becoming gradually narrower) of the distance between lumbar vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008489 ; owl:annotatedTarget "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the fifth lumbar vertebral body (L5) onto the sacrum (level S1)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:17156784" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008491 ; owl:annotatedTarget "Early closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008494 ; owl:annotatedTarget "Partial displacement of the lens in the inferior direction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008494 ; owl:annotatedTarget "Inferior subluxated lens" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008496 ; owl:annotatedTarget "Extra rows of eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008496 ; owl:annotatedTarget "Multiple rows of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0008496 ; owl:annotatedTarget "Double row of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0008496 ; owl:annotatedTarget "Two rows of eyelashes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:184223" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008498 ; owl:annotatedTarget "Absence of adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008498 ; owl:annotatedTarget "Absence of secondary dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008498 ; owl:annotatedTarget "Missing adult teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008498 ; owl:annotatedTarget "No adult dentition" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008498 ; owl:annotatedTarget "No secondary dentition" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008499 ; owl:annotatedTarget "A severe form of hypermetropia with over +5.00 diopters." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008499 ; owl:annotatedTarget "Severe farsightedness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008499 ; owl:annotatedTarget "Severe long-sightedness" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:19817701" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008501 ; owl:annotatedTarget "Cleft lip or palate affecting the midline region of the palate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008501 ; owl:annotatedTarget "Central cleft lip and palate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008501 ; owl:annotatedTarget "Midline cleft lip/palate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:23964472" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008504 ; owl:annotatedTarget "The presence of a moderate form of sensorineural hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008511 ; owl:annotatedTarget "Reduced transparency of the central posterior portion of the corneal stroma." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:24304198" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008513 ; owl:annotatedTarget "A bilateral type of conductive hearing impairment." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:2838261" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008515 ; owl:annotatedTarget "Absent/small vertebrae" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008515 ; owl:annotatedTarget "Absent/underdeveloped vertebrae" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:2997282" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008517 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the sacral bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008517 ; owl:annotatedTarget "Absent/small sacrum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008517 ; owl:annotatedTarget "Absent/underdeveloped sacrum" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:3494111" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/small backbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/small spine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/small vertebral column" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:6265326" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/underdeveloped backbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/underdeveloped spine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008518 ; owl:annotatedTarget "Absent/underdeveloped vertebral column" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "PMID:9627702" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008519 ; owl:annotatedTarget "Any structural abnormality of the coccyx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008519 ; owl:annotatedTarget "Abnormal tailbone" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008523 ; owl:annotatedTarget "Permanent indentation on the posteromedial aspect of the helix that may be sharply or indistinctly delineated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008523 ; owl:annotatedTarget "Indentation in back of outer ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008527 ; owl:annotatedTarget "A type of hearing impairment caused by an abnormal functionality of the cochlear nerve with congenital onset." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0008528 ; owl:annotatedTarget "Ear hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008528 ; owl:annotatedTarget "Long hairs growing from helix of ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008529 ; owl:annotatedTarget "Absence of the acoustic reflex, an involuntary contraction of the stapedius muscle that occurs in response to high-intensity sound stimuli." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008537 ; owl:annotatedTarget "Cleft at the superior portion of the ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008541 ; owl:annotatedTarget "High set ears" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Reaxys:2339331" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008542 ; owl:annotatedTarget "A type of hearing impairment affecting primarily the low frequencies of sound (125 Hz to 1000 Hz)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008542 ; owl:annotatedTarget "Low-frequency hearing loss" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008544 ; owl:annotatedTarget "Any structural anomaly of the border of the helix, which usually forms a rolled rim but is highly variable in shape." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol" . [] oboInOwl:hasDbXref , "PMID:19152421", "PMID:3270622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008551 ; owl:annotatedTarget "Underdevelopment of the external ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008551 ; owl:annotatedTarget "Small ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008551 ; owl:annotatedTarget "Underdeveloped ears" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "calciol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008554 ; owl:annotatedTarget "The presence of a malformed cochlea." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "calciol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008555 ; owl:annotatedTarget "Complete lack of functioning of the vestibular apparatus." . [] oboInOwl:hasDbXref , "PMID:26918204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008568 ; owl:annotatedTarget "Vestibular areflexia can be measured as the absence of the caloric nystagmus response in electronystagmography." . [] oboInOwl:hasDbXref "PMID:19152421", "eom:ae27d9699faef13a" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008569 ; owl:annotatedTarget "Median longitudinal length of the ear more than two standard deviations below the mean in the presence of some, but not all, parts of the normal ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008569 ; owl:annotatedTarget "Cockleshell ear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008569 ; owl:annotatedTarget "Mini ear" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "(+)-vitamin D3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008569 ; owl:annotatedTarget "Shell ear" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008569 ; owl:annotatedTarget "Snail ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008572 ; owl:annotatedTarget "A malformation of the auricle of the ear." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008572 ; owl:annotatedTarget "External ear malformation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008573 ; owl:annotatedTarget "A form of sensorineural hearing impairment that affects primarily the lower frequencies." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008577 ; owl:annotatedTarget "Underdevelopment of the helix that either affects the entire helix, or is localized." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008583 ; owl:annotatedTarget "A condition in which the superior portion of the helix is folded over to a lesser degree than normal." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008586 ; owl:annotatedTarget "Developmental hypoplasia of the cochlea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008586 ; owl:annotatedTarget "Underdeveloped cochlea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008587 ; owl:annotatedTarget "The presence of a mild form of sensorineural hearing impairment." . [] oboInOwl:hasDbXref "PMID:12843316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008588 ; owl:annotatedTarget "A type of stenosis of the external auditory meatus in which the opening of the external auditory meatus appears as a vertical slit." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008589 ; owl:annotatedTarget "Underdevelopment of the helix, i.e., of the outer rim of the pinna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008589 ; owl:annotatedTarget "Underdeveloped helices" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008591 ; owl:annotatedTarget "A type of conductive deafness with congenital onset." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "CC" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008593 ; owl:annotatedTarget "Increased anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008596 ; owl:annotatedTarget "A form of sensorineural hearing impairment with onset after the acquisition of speech." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Cholecalciferol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008598 ; owl:annotatedTarget "A mild form of conductive hearing impairment." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008605 ; owl:annotatedTarget "Deformed external ear on one side" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008606 ; owl:annotatedTarget "Benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008606 ; owl:annotatedTarget "Pit above the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008606 ; owl:annotatedTarget "Supraauricular fistula" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Delta-D" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008607 ; owl:annotatedTarget "A progressive type of conductive deafness." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Vitamin D3" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008609 ; owl:annotatedTarget "An abnormality of the morphology or structure of the middle ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008609 ; owl:annotatedTarget "Middle ear malformation" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "Vitamin D3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008609 ; owl:annotatedTarget "Morphological abnormality of the middle ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008610 ; owl:annotatedTarget "A form of sensorineural hearing impairment with infantile onset." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008615 ; owl:annotatedTarget "The presence of sensorineural deafness with late onset." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "activated 7-dehydrocholesterol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008619 ; owl:annotatedTarget "A bilateral form of sensorineural hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008625 ; owl:annotatedTarget "A severe form of sensorineural hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008625 ; owl:annotatedTarget "Severe sensorineural deafness" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "colecalciferol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008628 ; owl:annotatedTarget "An abnormality of the stapes, a stirrup-shaped ossicle in the middle ear." . [] oboInOwl:hasDbXref "PMID:23885280" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008629 ; owl:annotatedTarget "Pulsatile tinnitus is generally classified a kind of objective tinnitus, meaning that it is not only audible to the patient but also to the examiner on auscultation of the auditory canal and/or of surrounding structures with use of an auscultation tube or stethoscope. Usually, pulsatile tinnitus is heard as a lower pitched thumping or booming, a rougher blowing sound which is coincidental with respiration, or as a clicking, higher pitched rhythmic sensation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008631 ; owl:annotatedTarget "A developmental anomaly of the ureter." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "oleovitamin D3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28940 ; owl:annotatedTarget "vitamin D3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008635 ; owl:annotatedTarget "Abnormal enlargement of the urinary bladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008639 ; owl:annotatedTarget "Underdeveloped gonad" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28963 ; owl:annotatedTarget "PMID:18424273" . [] oboInOwl:hasDbXref , "PMID:10707720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008643 ; owl:annotatedTarget "Presence of persistent islands of renal blastema in the postnatal kidney. Nephroblastomatosis represents a complex abnormality of nephrogenesis and has been defined as the persistence of metanephricblastema into infancy and childhood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28963 ; owl:annotatedTarget "PMID:9056391" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28963 ; owl:annotatedTarget "Aminosugars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008652 ; owl:annotatedTarget "Impotence (inability to develop or maintain an erection) resulting from abnormal functioning of the autonomic nervous system." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008653 ; owl:annotatedTarget "A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28963 ; owl:annotatedTarget "amino sugars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008655 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the fallopian tube." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008655 ; owl:annotatedTarget "Absent/small fallopian tube" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008655 ; owl:annotatedTarget "Absent/underdeveloped fallopian tube" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008659 ; owl:annotatedTarget "The presence of many cysts in the medulla of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008660 ; owl:annotatedTarget "A developmental defect characterized by absence or poor development of proximal renal tubules." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28963 ; owl:annotatedTarget "aminosugar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008661 ; owl:annotatedTarget "Abnormal narrowing of the urethra." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008661 ; owl:annotatedTarget "Narrowing of the urethra" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008663 ; owl:annotatedTarget "A sarcoma of the kidney." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28965 ; owl:annotatedTarget "dicarboxylic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008665 ; owl:annotatedTarget "Hypertrophy of the clitoris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008665 ; owl:annotatedTarget "Enlarged clitoris" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008668 ; owl:annotatedTarget "Unusual gonadal development in a person with a 46,XY male karyotype, leading to an unassigned sex differentiation." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28965 ; owl:annotatedTarget "a dicarboxylate" . [] oboInOwl:hasDbXref , "MP:0001156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008669 ; owl:annotatedTarget "Incomplete maturation or aberrant formation of the male gametes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008669 ; owl:annotatedTarget "Abnormal sperm development" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "The presence of calcium- and oxalate-containing calculi (stones) in the kidneys." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca oxalate kidney stone" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca oxalate nephrolithiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca oxalate urolithiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca2+ oxalate kidney stone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28965 ; owl:annotatedTarget "dicarboxylate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca2+ oxalate nephrolithiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Ca2+ oxalate urolithiasis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008672 ; owl:annotatedTarget "Calcium oxalate kidney stones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008675 ; owl:annotatedTarget "Enlarged ovaries with cysts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008676 ; owl:annotatedTarget "A developmental disturbance with extreme ureteral dilatation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008677 ; owl:annotatedTarget "Nephrotic syndrome with onset within the first three months of life." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28965 ; owl:annotatedTarget "dicarboxylates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008678 ; owl:annotatedTarget "Absence or underdevelopment of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008678 ; owl:annotatedTarget "Absent/small kidney" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008678 ; owl:annotatedTarget "Absent/underdeveloped kidney" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28965 ; owl:annotatedTarget "dicarboxylic acid dianions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008682 ; owl:annotatedTarget "Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008683 ; owl:annotatedTarget "Increase in size of the folds of skin between the outer labia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008684 ; owl:annotatedTarget "Absence or developmental hypoplasia of the uterus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008684 ; owl:annotatedTarget "Absent/small uterus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008684 ; owl:annotatedTarget "Absent/underdeveloped uterus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008687 ; owl:annotatedTarget "Underdeveloped prostate" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "CAS:463-79-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008689 ; owl:annotatedTarget "Absence of both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008691 ; owl:annotatedTarget "Presence of a single diverticulum (sac or pouch) in the wall of the urinary bladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008695 ; owl:annotatedTarget "Transient nephrosis" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "CAS:463-79-6" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "Gmelin:25554" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008696 ; owl:annotatedTarget "A disordered proliferation of mature tissues that are native to the kidneys." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008697 ; owl:annotatedTarget "Developmental hypoplasia of the fallopian tube." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008697 ; owl:annotatedTarget "Underdeveloped fallopian tube" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "Carbonic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "carbonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008703 ; owl:annotatedTarget "Deposition of calcium salts in gonadal tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008707 ; owl:annotatedTarget "Congenital absence of the scrotum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008707 ; owl:annotatedTarget "Absent scrotum" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "dihydroxidooxidocarbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008711 ; owl:annotatedTarget "The presence of non-malignant hyperplasia of the prostate." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "Dihydrogen carbonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008716 ; owl:annotatedTarget "The presence of a fistula between the vagina and the urethra." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "H2CO3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008717 ; owl:annotatedTarget "A unilateral form of atrophy of the kidney." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "H2CO3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008717 ; owl:annotatedTarget "Kidney degeneration on one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008717 ; owl:annotatedTarget "Unilateral kidney wasting" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "Koehlensaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008718 ; owl:annotatedTarget "A unilateral form of developmental dysplasia of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008722 ; owl:annotatedTarget "The presence of a diverticulum (sac or pouch) in the wall of the urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008723 ; owl:annotatedTarget "Unusual gonadal development in a person with a 46,XY male karyotype, leading to a more female sex differentiation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_28976 ; owl:annotatedTarget "[CO(OH)2]" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008724 ; owl:annotatedTarget "Developmental hypoplasia of the ovary." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008724 ; owl:annotatedTarget "Underdeveloped ovary" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008726 ; owl:annotatedTarget "Developmental hypoplasia of the vagina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008726 ; owl:annotatedTarget "Underdeveloped vagina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008729 ; owl:annotatedTarget "Absent vaginal lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008730 ; owl:annotatedTarget "The presence of female external genitalia in a person with a male karyotype." . [] oboInOwl:hasDbXref "PMID:22392950", "PMID:30180816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008732 ; owl:annotatedTarget "Renal hypophosphatemia is defined as reduced serum phosphate (e.g., below 0.70 mmol/l) and an inappropriately high renal phosphate excretion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008734 ; owl:annotatedTarget "Reduced volume of the testicle (the male gonad)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008734 ; owl:annotatedTarget "Decreased testicular size" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008734 ; owl:annotatedTarget "Small testes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008734 ; owl:annotatedTarget "Small testis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008736 ; owl:annotatedTarget "Underdeveloped penis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008738 ; owl:annotatedTarget "The presence of a partially duplicated kidney." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008738 ; owl:annotatedTarget "Partially duplicated kidney" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008740 ; owl:annotatedTarget "The presence of a longitudinal vaginal septum, thereby creating a vaginal duplication." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Beilstein:506007" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "Beilstein:1725411" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008743 ; owl:annotatedTarget "A mild form of hypospadias in which the urethra opens just under the corona glandis." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "CAS:7200-25-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008744 ; owl:annotatedTarget "An abnormality of the aryepiglottic fold." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "PMID:10848923" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008747 ; owl:annotatedTarget "Ossification affecting the set of cartilages of larynx." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "Reaxys:1725411" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008749 ; owl:annotatedTarget "Underdevelopment of the larynx." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "Arginine" . [] oboInOwl:hasDbXref , "PMID:10517457", "PMID:17715321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008750 ; owl:annotatedTarget "Congenital absence of the lumen of the larynx. Laryngeal atresia is a rare condition. If the laryngeal opening fails to develop, fluid secreted by the lungs cannot be expelled. In a fetus with laryngeal atresia, the lungs are either normal or hyperplastic, not hypoplastic. Mortality is reported as 100%. At obstetric US examination, views of the fetal neck demonstrate a dilated trachea filled with trapped fluid. Views of the fetal chest show enlarged, hyperechoic lungs, with dilated fluid-filled bronchi. Fetal ascites is usually present." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "arginine" . [] oboInOwl:hasDbXref , "PMID:17178945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008751 ; owl:annotatedTarget "Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esophagus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008752 ; owl:annotatedTarget "A malformation of the laryngeal cartilage." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "2-Amino-5-guanidinovaleric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008753 ; owl:annotatedTarget "Absence of the epiglottis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008753 ; owl:annotatedTarget "Absent epiglottis" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "2-amino-5-(carbamimidamido)pentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008754 ; owl:annotatedTarget "Calcification (abnormal deposits of calcium) in the laryngeal tissues." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008754 ; owl:annotatedTarget "Laryngeal calcifications" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "2-amino-5-guanidinopentanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008756 ; owl:annotatedTarget "Bowing (abnormal curvature) of the vocal folds." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "Arginin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008757 ; owl:annotatedTarget "A loss of the ability to move the vocal fold on one side." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "CAS:64-19-7" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29016 ; owl:annotatedTarget "Harg" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008760 ; owl:annotatedTarget "Violent behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008760 ; owl:annotatedTarget "Violent behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008762 ; owl:annotatedTarget "Repetitive compulsive behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008762 ; owl:annotatedTarget "Repetitive compulsive behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008763 ; owl:annotatedTarget "No social interaction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008765 ; owl:annotatedTarget "Hallucinations of sound" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008765 ; owl:annotatedTarget "Hearing sounds" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008767 ; owl:annotatedTarget "Self-mutilation of tongue and lips due to involuntary movements" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29067 ; owl:annotatedTarget "a carboxylate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008768 ; owl:annotatedTarget "Inappropriate sexual behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008768 ; owl:annotatedTarget "Inappropriate sexual behaviour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008770 ; owl:annotatedTarget "The presence of one or more obsessive-compulsive personality traits. Obsessions refer to persistent intrusive thoughts, and compulsions to intrusive behaviors, which the affected person experiences as involuntary, senseless, or repugnant." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008770 ; owl:annotatedTarget "Obsessive-compulsive trait" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008770 ; owl:annotatedTarget "Obsessive-compulsive traits" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29067 ; owl:annotatedTarget "carboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008771 ; owl:annotatedTarget "The presence of aplasia or developmental hypoplasia of the ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008771 ; owl:annotatedTarget "Absent/small ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008771 ; owl:annotatedTarget "Absent/underdeveloped ear" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29067 ; owl:annotatedTarget "carboxylic anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008772 ; owl:annotatedTarget "The presence of aplasia or developmental hypoplasia of all or part of the external ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008772 ; owl:annotatedTarget "Absent/small external ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008772 ; owl:annotatedTarget "Absent/underdeveloped external ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008773 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of all or part of the middle ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008773 ; owl:annotatedTarget "Absent/small middle ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008773 ; owl:annotatedTarget "Absent/underdeveloped middle ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008774 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the inner ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008774 ; owl:annotatedTarget "Absent/small inner ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008774 ; owl:annotatedTarget "Absent/underdeveloped inner ear" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "CAS:17341-25-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008775 ; owl:annotatedTarget "An abnormality of the prostate." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008775 ; owl:annotatedTarget "Abnormality of the prostate" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "CAS:17341-25-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008776 ; owl:annotatedTarget "Any structural abnormality of the renal artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008776 ; owl:annotatedTarget "Abnormal kidney artery" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "Gmelin:15196" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008777 ; owl:annotatedTarget "An abnormality of the vocal cord." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008777 ; owl:annotatedTarget "Abnormality of the vocal cords" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "CAS:64-19-7" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "sodium cation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "sodium(1+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008783 ; owl:annotatedTarget "Increased width of the proximal part of the shaft (metaphysis) of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008783 ; owl:annotatedTarget "Wide metaphysis of innermost thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "sodium(1+) ion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008784 ; owl:annotatedTarget "Abnormally wide morphology of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008784 ; owl:annotatedTarget "Wide end part of innermost thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "sodium(I) cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008785 ; owl:annotatedTarget "Delayed maturation and calcification of the rami (branches) of the pubic bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008786 ; owl:annotatedTarget "Irregularities of the iliac crest that produce the appearance of a lace border around it." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "Na(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008788 ; owl:annotatedTarget "Delayed maturation and calcification of the pubic bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008788 ; owl:annotatedTarget "Delayed maturation fo pubic bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "Na(+)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008788 ; owl:annotatedTarget "Delayed mineralization of pubic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008789 ; owl:annotatedTarget "A cone-shaped deformity of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008789 ; owl:annotatedTarget "Cone-shaped end part of innermost thighbone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "Na+" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008794 ; owl:annotatedTarget "Dysplastic iliac wings" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29101 ; owl:annotatedTarget "SODIUM ION" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008796 ; owl:annotatedTarget "Externally rotated hips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008797 ; owl:annotatedTarget "Developmental acceleration of ossification of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008798 ; owl:annotatedTarget "The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a increase in the lateral dimension of the notch." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008800 ; owl:annotatedTarget "A decreased ability to move the femur at the hip joint associated with a decreased range of motion of the hip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008800 ; owl:annotatedTarget "Limited hip movement" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "CAS:64-19-7" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "CAS:24203-36-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008801 ; owl:annotatedTarget "Underdevelopment of the lesser trochanter." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "Gmelin:15203" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008802 ; owl:annotatedTarget "Underdevelopment of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008802 ; owl:annotatedTarget "Small head of thigh bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "potassium cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008804 ; owl:annotatedTarget "Increased width of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008804 ; owl:annotatedTarget "Wide head of thigh bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "potassium(1+)" . [] oboInOwl:hasDbXref , , "PMID:23764788", "PMID:34377520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008807 ; owl:annotatedTarget "A smaller than normal acetabulum that has insufficient femoral head coverage leading to abnormal hip joint contact pressures, instability and pain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008808 ; owl:annotatedTarget "Increased height of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "potassium(1+) ion" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008808 ; owl:annotatedTarget "High iliac wings" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008812 ; owl:annotatedTarget "An abnormally flattened femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008812 ; owl:annotatedTarget "Flat head of thigh bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "potassium(I) cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008812 ; owl:annotatedTarget "Flattened femoral heads" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008817 ; owl:annotatedTarget "Absent pubic bones" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008817 ; owl:annotatedTarget "Aplastic pubic bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "K(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008818 ; owl:annotatedTarget "Increased size of the ilium ala." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008818 ; owl:annotatedTarget "Large iliac wings" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "K(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008819 ; owl:annotatedTarget "An abnormally reduced diameter of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008819 ; owl:annotatedTarget "Narrow neck of thigh bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008819 ; owl:annotatedTarget "Narrow femoral necks" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "K+" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29103 ; owl:annotatedTarget "POTASSIUM ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008820 ; owl:annotatedTarget "Lack of ossification of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008822 ; owl:annotatedTarget "Underdevelopment of the ischiopubic ramus, which is comprised of the inferior pubic ramus and the inferior ramus of the ischium." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008822 ; owl:annotatedTarget "Hypoplastic ischiopubic rami" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Drug_Central:4211" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008824 ; owl:annotatedTarget "Underdevelopment of the body of ilium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008824 ; owl:annotatedTarget "Hypoplastic iliac bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008824 ; owl:annotatedTarget "Small iliac bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008826 ; owl:annotatedTarget "Joint dislocation of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008826 ; owl:annotatedTarget "Dislocated head of thigh bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "Gmelin:1404640" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "hydridohydroxidodioxidosulfur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008828 ; owl:annotatedTarget "Developmental delay of ossification of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "sulfonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008829 ; owl:annotatedTarget "Delayed ossification of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008829 ; owl:annotatedTarget "Delayed maturation of the head of the thigh bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "HSHO3" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008830 ; owl:annotatedTarget "Hypoplastic pubic rami" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "Sulfonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008835 ; owl:annotatedTarget "There is normally one ossification center in the head of the femur. This term applies if there are multiple such centers." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "[SHO2(OH)]" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008838 ; owl:annotatedTarget "Speckled calcifications in end part of innermost long bone of upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "acide sulfonique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008839 ; owl:annotatedTarget "Underdevelopment of the bony pelvis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008845 ; owl:annotatedTarget "A type of disproportionate short stature characterized by disproportionate shortening of the medial parts of the extremities (forearm or lower leg)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29214 ; owl:annotatedTarget "sulphonic acid" . [] oboInOwl:hasSynonymType hp:obsolete_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008845 ; owl:annotatedTarget "Mesomelic dwarfism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008846 ; owl:annotatedTarget "Intrauterine growth retardation that is 4 or more standard deviations below average, corrected for sex and gestational age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008846 ; owl:annotatedTarget "Severe prenatal growth deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008848 ; owl:annotatedTarget "A moderate degree of short stature, more than -3 SD but not more than -4 SD from mean corrected for age and sex." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008848 ; owl:annotatedTarget "Moderate short stature" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008848 ; owl:annotatedTarget "Short stature, moderate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008850 ; owl:annotatedTarget "Severely slow or limited growth after birth, being four standard deviations or more below age- and sex-related norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008850 ; owl:annotatedTarget "Marked growth retardation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008850 ; owl:annotatedTarget "Severe growth delay in children" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008850 ; owl:annotatedTarget "Severe postnatal growth failure" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Gmelin:1380" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008855 ; owl:annotatedTarget "A moderate degree of slow or limited growth after birth, being between three and four standard deviations below age- and sex-related norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008855 ; owl:annotatedTarget "Moderate growth delay in children" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008857 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with congenital onset recognizable at birth." . [] oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Failure_to_thrive" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008866 ; owl:annotatedTarget "Insufficient weight gain or inappropriate weight loss for a child, that is attributed to an endogenous recurrent infections." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008866 ; owl:annotatedTarget "Faltering weight secondary to recurrent infections" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008866 ; owl:annotatedTarget "Weight faltering secondary to recurrent infections" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008872 ; owl:annotatedTarget "Impaired feeding performance of an infant as manifested by difficulties such as weak and ineffective sucking, brief bursts of sucking, and falling asleep during sucking. There may be difficulties with chewing or maintaining attention." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008873 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short limbs but an average-sized trunk." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008873 ; owl:annotatedTarget "Short limb dwarfism, disproportionate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008873 ; owl:annotatedTarget "Short-limbed dwarfism" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008873 ; owl:annotatedTarget "Short limb dwarfism" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008883 ; owl:annotatedTarget "Intrauterine growth retardation that is at least 2 standard deviations (SD) below average, but not as low as 3 SD, corrected for sex and gestational age." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29337 ; owl:annotatedTarget "amide" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29337 ; owl:annotatedTarget "azanide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008887 ; owl:annotatedTarget "A loss of adipose tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008887 ; owl:annotatedTarget "Loss of fat tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008897 ; owl:annotatedTarget "Slow or limited growth after birth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008897 ; owl:annotatedTarget "Growth delay as children" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008905 ; owl:annotatedTarget "Disproportionate shortening of the proximal segment of limbs (i.e. the femur and humerus)." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008905 ; owl:annotatedTarget "Disproportionately short upper portion of limb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008915 ; owl:annotatedTarget "Truncal obesity with onset during childhood, defined as between 2 and 10 years of age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008921 ; owl:annotatedTarget "A type of short-limbed dwarfism that is manifest beginning in the neonatal period." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008921 ; owl:annotatedTarget "Short limb dwarfism recognisable at birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008921 ; owl:annotatedTarget "Short limb dwarfism recognizable at birth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29337 ; owl:annotatedTarget "dihydridonitrate(1-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008921 ; owl:annotatedTarget "Short-limb dwarfism identifiable at birth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008921 ; owl:annotatedTarget "Short-limbed dwarfism identifiable at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008922 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in childhood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008922 ; owl:annotatedTarget "Childhood-onset short-trunk short stature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008922 ; owl:annotatedTarget "Disproportionate short-trunk short stature, identifiable in childhood" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008922 ; owl:annotatedTarget "Short-trunk dwarfism identifiable during childhood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008935 ; owl:annotatedTarget "Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period and affecting the entire musculature." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008935 ; owl:annotatedTarget "Generalised low muscle tone in neonate" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008935 ; owl:annotatedTarget "Generalised neonatal hypotonia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008935 ; owl:annotatedTarget "Generalized low muscle tone in neonate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29337 ; owl:annotatedTarget "NH2(-)" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008935 ; owl:annotatedTarget "Hypotonia, neonatal, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008936 ; owl:annotatedTarget "Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008936 ; owl:annotatedTarget "Low muscle tone in trunk" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008940 ; owl:annotatedTarget "A generalized form of lymphadenopathy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008940 ; owl:annotatedTarget "Generalised lymphadenopathy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008940 ; owl:annotatedTarget "Generalised swelling of lymph nodes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008940 ; owl:annotatedTarget "Generalized swelling of lymph nodes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008940 ; owl:annotatedTarget "Swollen lymph nodes affecting all regions of the body" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008942 ; owl:annotatedTarget "An acute form of rhabdomyolysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008944 ; owl:annotatedTarget "Muscular atrophy of distal leg muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008944 ; owl:annotatedTarget "Lower limb degeneration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29340 ; owl:annotatedTarget "azanediide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008946 ; owl:annotatedTarget "Atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008947 ; owl:annotatedTarget "Muscular hypotonia (abnormally low muscle tone) manifesting in infancy." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008947 ; owl:annotatedTarget "Decreased muscle tone in infant" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29340 ; owl:annotatedTarget "hydridonitrate(2-)" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29340 ; owl:annotatedTarget "NH(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008948 ; owl:annotatedTarget "Muscular atrophy affecting proximally located muscles of the arms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008952 ; owl:annotatedTarget "Underdevelopment of muscles of the shoulder." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010002" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29340 ; owl:annotatedTarget "imide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008952 ; owl:annotatedTarget "Underdeveloped shoulder muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008953 ; owl:annotatedTarget "Underdevelopment of the pectoralis major." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008954 ; owl:annotatedTarget "Atrophy of the intrinsic muscle groups of the hand, comprising the thenar and hypothenar muscles; the interossei muscles; and the lumbrical muscles." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29347 ; owl:annotatedTarget "monocarboxylic acid amides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008955 ; owl:annotatedTarget "Progressive muscular atrophy affecting muscles in the distal portions of the extremities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008956 ; owl:annotatedTarget "Muscular atrophy affecting proximally located muscles of the legs, i.e., of the thigh." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008956 ; owl:annotatedTarget "Wasting of thigh muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008959 ; owl:annotatedTarget "Reduced strength of the distal musculature of the arms." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "Gmelin:508" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008962 ; owl:annotatedTarget "Underdevelopment of the muscuklature of the calf." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008962 ; owl:annotatedTarget "Underdeveloped calf muscles" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "dioxidenium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008963 ; owl:annotatedTarget "Muscle weakness affecting the tibialis anterior muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008964 ; owl:annotatedTarget "Muscular atrophy that does not display a progression in severity with time." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "hydridodioxygen(1+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008967 ; owl:annotatedTarget "A type of muscle stiffness that occurs following physical exertion." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008967 ; owl:annotatedTarget "Exercise-induced muscle stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008967 ; owl:annotatedTarget "Muscle stiffness with exercise" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008967 ; owl:annotatedTarget "Muscle stiffness, exercise-induced" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "HO2(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008968 ; owl:annotatedTarget "Muscle hypertrophy primarily affecting the legs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "HOO(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008972 ; owl:annotatedTarget "Decreased activity of the mitochondrial respiratory chain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008972 ; owl:annotatedTarget "Decreased activities of mitochondrial-encoded respiratory chain complexes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008972 ; owl:annotatedTarget "Decreased activity of mitochondrial respiratory complexes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29793 ; owl:annotatedTarget "[HO2](+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008981 ; owl:annotatedTarget "Muscle hypertrophy affecting the calf muscles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008981 ; owl:annotatedTarget "Increased size of calf muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Underdevelopment of muscles of the neck." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Decreased size of neck muscle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Small neck muscle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Underdevelopment of neck muscle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Deficiency of neck muscle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:12005138" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0008984 ; owl:annotatedTarget "Hypotrophic neck muscle" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "CAS:2466-09-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008985 ; owl:annotatedTarget "An abnormal increase in the amount of intramuscular fat tissue." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008985 ; owl:annotatedTarget "Increased IM fat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008985 ; owl:annotatedTarget "Increased intramuscular fat" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "CAS:2466-09-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008986 ; owl:annotatedTarget "Congenital lack, i.e., aplasia of the diaphragm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008986 ; owl:annotatedTarget "Absent diaphragm" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "CAS:2466-09-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008988 ; owl:annotatedTarget "Muscular atrophy affecting the muscles that attach to the pelvic girdle (the gluteal muscles, the lateral rotators, adductor magnus, adductor brevis, adductor longus, pectineus, and gracilis muscles)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008991 ; owl:annotatedTarget "Sudden and involuntary contractions of one or more muscles of the leg brought on by physical exertion." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Gmelin:82619" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008993 ; owl:annotatedTarget "An abnormal increase in the amount of intraabdominal fat tissue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "PMID:6291941" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008994 ; owl:annotatedTarget "A lack of strength of the proximal muscles of the legs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008997 ; owl:annotatedTarget "A lack of strength of the proximal muscles of the arms." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Reaxys:3942075" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0008998 ; owl:annotatedTarget "Underdevelopment of the pectoral muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008998 ; owl:annotatedTarget "Small pec muscle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0008998 ; owl:annotatedTarget "Underdeveloped pec muscle" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "1,5-dihydrido-2,4-dihydroxido-2,4-dioxido-1,3,5-trioxy-2,4-diphosphy-[5]catena" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009002 ; owl:annotatedTarget "Loss (reduction of previously present) of subcutaneous adipose tissue in the region of the trunk." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009002 ; owl:annotatedTarget "Loss of fat tissue in trunk" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Diphosphoric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009003 ; owl:annotatedTarget "The presence of an abnormally increased amount of subcutaneous adipose tissue in the trunk of the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009003 ; owl:annotatedTarget "Increased fat below the skin in trunk" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "diphosphoric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009004 ; owl:annotatedTarget "Underdevelopment of the musculature." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009004 ; owl:annotatedTarget "Poorly developed skeletal musculature" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009004 ; owl:annotatedTarget "Underdeveloped muscle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:15107950" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "mu-oxido-bis(dihydroxidooxidophosphorus)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009007 ; owl:annotatedTarget "Underdevelopment of the biceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009007 ; owl:annotatedTarget "Underdeveloped biceps" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Diphosphorsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009011 ; owl:annotatedTarget "Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "H4P2O7" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "PYROPHOSPHATE" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009016 ; owl:annotatedTarget "Underdevelopment of muscles of the arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009016 ; owl:annotatedTarget "Underdevelopment of upper limb muscles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Pyrophosphate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009017 ; owl:annotatedTarget "Loss (reduction of previously present) of subcutaneous adipose tissue in the gluteal region." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009017 ; owl:annotatedTarget "Loss of fat tissue below the skin in gluts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Atrophy of facial adipose tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Facial fat atrophy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Facial fat wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Progressive loss of facial fat" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Pyrophosphoric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Progressive loss of facial subcutaneous adipose tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009019 ; owl:annotatedTarget "Progressive loss of subcutaneous adipose tissue from face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009020 ; owl:annotatedTarget "An abnormally increased tendency towards muscle fatigue induced by physical exercise." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "Pyrophosphorsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009023 ; owl:annotatedTarget "Decreased strength of the abdominal musculature." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "[(HO)2P(O)OP(O)(OH)2]" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009025 ; owl:annotatedTarget "The presence of an abnormally increased amount of connective tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29888 ; owl:annotatedTarget "acide diphosphorique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009026 ; owl:annotatedTarget "Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009027 ; owl:annotatedTarget "Weakness of the muscles responsible for dorsiflexion of the foot, that is, of the movement of the toes towards the shin. The foot dorsiflexors include the tibialis anterior, the extensor hallucis longus, the extensor digitorum longus, and the peroneus tertius muscles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009027 ; owl:annotatedTarget "Foot drop" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009027 ; owl:annotatedTarget "Inability to heel walk" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009027 ; owl:annotatedTarget "Inability to walk on heels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009028 ; owl:annotatedTarget "Generalized weakness of the muscles of the arms and legs." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009028 ; owl:annotatedTarget "Generalised weakness of limb muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009031 ; owl:annotatedTarget "Atrophy of the muscles of the ankle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009045 ; owl:annotatedTarget "Rhabdomyolysis induced by exercise." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009046 ; owl:annotatedTarget "Reduced ability to run." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009046 ; owl:annotatedTarget "Difficulty running" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:16630552" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29922 ; owl:annotatedTarget "SULFO GROUP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009049 ; owl:annotatedTarget "Atrophy of the peroneous muscles, peroneus longus (also known as Fibularis longus), Peroneus brevis (also known as fibularis brevis, and Peroneus tertius (also known as fibularis tertius)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29922 ; owl:annotatedTarget "hydroxydioxo-lambda(6)-sulfanyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009050 ; owl:annotatedTarget "Muscular atrophy involving the quadriceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009050 ; owl:annotatedTarget "Wasting of quad muscles" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29922 ; owl:annotatedTarget "hydroxysulfonyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009051 ; owl:annotatedTarget "An increased amount of glycogen in muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009053 ; owl:annotatedTarget "Reduced strength of the distal musculature of the legs." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29922 ; owl:annotatedTarget "sulfo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009055 ; owl:annotatedTarget "Generalized (unlocalized) atrophy affecting muscles of the limbs in both proximal and distal locations." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29922 ; owl:annotatedTarget "-S(O)2(OH)" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009055 ; owl:annotatedTarget "Generalised limb muscle atrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009055 ; owl:annotatedTarget "Generalised muscle atrophy, proximal and distal" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009055 ; owl:annotatedTarget "Generalised muscle wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009055 ; owl:annotatedTarget "Generalized muscle wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009056 ; owl:annotatedTarget "Loss of fat tissue below the skin from upper limbs" . [] oboInOwl:hasDbXref , "PMID:20691590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "An abnormal accumulation of lipids in skeletal muscle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Fat accumulation in muscle fibers" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Fat accumulation in muscle fibres" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Fat deposits in muscle fibers" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Fat deposits in muscle fibres" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Increased muscle lipid content" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Lipid accumulation in skeletal muscle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009058 ; owl:annotatedTarget "Skeletal muscle lipid accumulation" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009059 ; owl:annotatedTarget "Congenital generalised lipodystrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009060 ; owl:annotatedTarget "Atrophy of the muscles that are responsible for moving the scapula, which are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009062 ; owl:annotatedTarget "Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk and with onset in infancy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009063 ; owl:annotatedTarget "Progressively reduced strength of the distal musculature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009064 ; owl:annotatedTarget "Generalized degenerative changes of the fat tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009064 ; owl:annotatedTarget "Generalised lipodystrophy" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009064 ; owl:annotatedTarget "Lipodystrophy, generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009067 ; owl:annotatedTarget "Progressive spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009067 ; owl:annotatedTarget "Progressive spinal muscle degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009067 ; owl:annotatedTarget "Progressive spinal muscle wasting" . [] oboInOwl:hasDbXref "PMID:19349710" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009071 ; owl:annotatedTarget "Chronic muscle inflammation accompanied by muscle weakness." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:16774200" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "CAS:11070-68-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009072 ; owl:annotatedTarget "Decreased intensity of the Achilles reflex (also known as the ankle jerk reflex), which can be elicited by tapping the tendon is tapped while the foot is dorsiflexed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009073 ; owl:annotatedTarget "Lack of strength of the proximal muscles that becomes progressively more severe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009084 ; owl:annotatedTarget "Midline cleft of maxillary alveolar process" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009084 ; owl:annotatedTarget "Midline cleft of upper alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009084 ; owl:annotatedTarget "Midline notch of maxillary alveolar process" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009084 ; owl:annotatedTarget "Midline notch of maxillary alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009084 ; owl:annotatedTarget "Midline notch of upper gum ridge" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "Gmelin:936654" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Increased width of the alveolar ridges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Increased size of gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Alveolar ridge excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Enlarged alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Hyperplasia of alveolar process of jaw" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "L-glutamate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Hyperplasia of alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Increased size of alveolar ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009085 ; owl:annotatedTarget "Overgrowth of gum ridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009087 ; owl:annotatedTarget "Posteriorly placed tongue" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "hydrogen L-glutamate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009092 ; owl:annotatedTarget "Increasing size of gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009092 ; owl:annotatedTarget "Progressive hypertrophy of alveolar process of jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009092 ; owl:annotatedTarget "Increasing overgrowth of gum ridge" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "(2S)-2-ammoniopentanedioate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Cleft of lower gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Notch of lower alveolar ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Notch of lower gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Notch of mandibular alveolar ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Cleft of lower alveolar process" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Cleft of lower gingiva" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Cleft of mandibular alveolar process" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "L-glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Cleft of mandibular gingiva" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Notch of lower alveolar process" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009094 ; owl:annotatedTarget "Notch of mandibular alveolar process" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009098 ; owl:annotatedTarget "Chronic oral thrush" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "L-glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009099 ; owl:annotatedTarget "Cleft palate of the midline of the palate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009099 ; owl:annotatedTarget "Central cleft palate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009099 ; owl:annotatedTarget "Midline cleft palate" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "L-glutamic acid monoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009100 ; owl:annotatedTarget "Thick anterior alveolar process of jaw" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29985 ; owl:annotatedTarget "L-glutamic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009101 ; owl:annotatedTarget "A cleft of the lip with overlying mucous membrane." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009101 ; owl:annotatedTarget "Submucous labial cleft" . [] oboInOwl:hasDbXref , "PMID:27615261" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Anterior open bite is a malocclusion characterized by a gap between the anterior teeth (incisors), that is, by a deficiency in the normal vertical overlap between antagonist incisal edges when the posterior teeth are in occlusion." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "AOB" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Absence of overlap of anterior upper and lower teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Anterior open bite between upper and lower teeth" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Anterior openbite" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Apertognathia malocclusion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009102 ; owl:annotatedTarget "Gap between upper and lower front teeth when biting" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009103 ; owl:annotatedTarget "Absent/small pelvis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009103 ; owl:annotatedTarget "Absent/underdeveloped pelvis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009104 ; owl:annotatedTarget "Absence or underdevelopment of the pubic bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009104 ; owl:annotatedTarget "Absent/small pubic bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009104 ; owl:annotatedTarget "Absent/underdeveloped pubic bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009104 ; owl:annotatedTarget "Hypoplastic/aplastic pubic bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "Beilstein:8319427" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009105 ; owl:annotatedTarget "Abnormal ossification (bone tissue formation) affecting the pubic bone, also known as the pubis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009105 ; owl:annotatedTarget "Abnormal maturation of the pubic bone" . ( ) . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "D-glutamate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009106 ; owl:annotatedTarget "An abnormality of the formation and mineralization of any bone of the bony pelvis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009106 ; owl:annotatedTarget "Abnormal maturation of the pelvis bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "hydrogen D-glutamate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "(2R)-2-ammoniopentanedioate" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0009107 ; owl:annotatedTarget _:genid64239 . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009107 ; owl:annotatedTarget "Abnormal maturation of thigh bone head and neck" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009108 ; owl:annotatedTarget "Absent/small head and neck of thighbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009108 ; owl:annotatedTarget "Absent/underdeveloped head and neck of thighbone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "D-glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009109 ; owl:annotatedTarget "Interruption of the innervation of the diaphragm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009110 ; owl:annotatedTarget "A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009112 ; owl:annotatedTarget "Congenital absence of the left half of the diaphragm." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29986 ; owl:annotatedTarget "D-glutamic acid monoanion" . [] oboInOwl:hasDbXref , "PMID:2509822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009113 ; owl:annotatedTarget "A decrease in the strength of the diaphragm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009113 ; owl:annotatedTarget "Weak diaphragm" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009115 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of one or more components of the skeleton." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009115 ; owl:annotatedTarget "Absent/small skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009115 ; owl:annotatedTarget "Absent/underdeveloped skeleton" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:19416101" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009117 ; owl:annotatedTarget "Absence or underdevelopment of the maxilla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009117 ; owl:annotatedTarget "Underdevelopment of maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009117 ; owl:annotatedTarget "Underdevelopment of upper jaw bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "Beilstein:4134100" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009118 ; owl:annotatedTarget "Absence or underdevelopment of the mandible." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "Gmelin:327903" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009119 ; owl:annotatedTarget "Absence or underdevelopment of frontal sinus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009119 ; owl:annotatedTarget "Abnormally small frontal sinus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009120 ; owl:annotatedTarget "Absence or underdevelopment of a cranial sinus or sinuses." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "Reaxys:4134100" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009121 ; owl:annotatedTarget "An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "2-aminopentanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009122 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of bones of the axial skeleton." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009124 ; owl:annotatedTarget "An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009124 ; owl:annotatedTarget "Abnormality of adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009124 ; owl:annotatedTarget "Abnormality of fat tissue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009124 ; owl:annotatedTarget "Abnormality of fatty tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009125 ; owl:annotatedTarget "Degenerative changes of the fat tissue." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009125 ; owl:annotatedTarget "Inability to make and keep healthy fat tissue" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "glutamate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009126 ; owl:annotatedTarget "An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009126 ; owl:annotatedTarget "Increased adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009126 ; owl:annotatedTarget "Increased fat tissue" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29987 ; owl:annotatedTarget "glutamic acid dianion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009127 ; owl:annotatedTarget "Abnormal limb muscles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009127 ; owl:annotatedTarget "Muscle issues in the arms and/or legs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009128 ; owl:annotatedTarget "Absent/small muscles of extremities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009128 ; owl:annotatedTarget "Absent/underdeveloped muscles of extremities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009129 ; owl:annotatedTarget "Muscular atrophy involving the muscles of the upper limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009130 ; owl:annotatedTarget "Muscular atrophy involving the muscles of the hand." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:19469536" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29988 ; owl:annotatedTarget "Gmelin:327905" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009130 ; owl:annotatedTarget "Hand muscle degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009131 ; owl:annotatedTarget "A disease or lesion affecting the muscles of the thorax." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29988 ; owl:annotatedTarget "(2S)-2-aminopentanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009132 ; owl:annotatedTarget "This term applies to all changes in bone mineral density of the tarsal bones, which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29988 ; owl:annotatedTarget "L-glutamate" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29988 ; owl:annotatedTarget "L-glutamate(2-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009136 ; owl:annotatedTarget "Duplication involving bones of the feet" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29988 ; owl:annotatedTarget "L-glutamic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009138 ; owl:annotatedTarget "An abnormal union between bones or parts of bones lower limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009138 ; owl:annotatedTarget "Fusion involving the bones of the lower limbs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009140 ; owl:annotatedTarget "Fusion involving the bones of the feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009142 ; owl:annotatedTarget "Duplication of bones involving the upper extremities" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "Beilstein:8143000" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "Gmelin:327904" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009145 ; owl:annotatedTarget "Any structural anomaly of a cerebral artery. The cerebral arteries comprise three main pairs of arteries and their branches, which supply the cerebrum of the brain. These are the anterior cerebral artery, the middle cerebral artery, and the posterior cerebral artery." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009145 ; owl:annotatedTarget "Abnormality of cerebral artery" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009145 ; owl:annotatedTarget "Abnormality of the cerebral arteries" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "(2R)-2-aminopentanedioate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:22153255" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "D-glutamate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009147 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009147 ; owl:annotatedTarget "Enlarged end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009147 ; owl:annotatedTarget "Enlarged end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009147 ; owl:annotatedTarget "Enlarged end part of the outermost bone of pinky finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "D-glutamate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009148 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009148 ; owl:annotatedTarget "Small end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009148 ; owl:annotatedTarget "Small end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009148 ; owl:annotatedTarget "Small end part of the outermost bone of pinky finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29989 ; owl:annotatedTarget "D-glutamic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009149 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the distal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009149 ; owl:annotatedTarget "Triangular end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009149 ; owl:annotatedTarget "Triangular end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009149 ; owl:annotatedTarget "Triangular end part of the outermost bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009150 ; owl:annotatedTarget "Abnormality of the proximal phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009150 ; owl:annotatedTarget "Abnormality of the innermost bone little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009150 ; owl:annotatedTarget "Abnormality of the innermost bone pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009150 ; owl:annotatedTarget "Abnormality of the innermost bone pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009152 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009152 ; owl:annotatedTarget "Abnormality of end part of little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009152 ; owl:annotatedTarget "Abnormality of end part of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009152 ; owl:annotatedTarget "Abnormality of end part of pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009153 ; owl:annotatedTarget "Abnormality of the epiphysis of the proximal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009153 ; owl:annotatedTarget "Abnormality of end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009153 ; owl:annotatedTarget "Abnormality of end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009153 ; owl:annotatedTarget "Abnormality of end part of the innermost bone of pinky finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "Beilstein:8316944" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009154 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the proximal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009154 ; owl:annotatedTarget "Delta-shaped epiphysis of the proximal phalanx of the 5th finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009154 ; owl:annotatedTarget "Triangular end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009154 ; owl:annotatedTarget "Triangular end part of the innermost bone of pinkie finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "Reaxys:8316944" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009154 ; owl:annotatedTarget "Triangular end part of the innermost bone of pinky finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "PMID:22173419" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "D-aspartate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009155 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the proximal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009155 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009155 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009155 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "hydrogen D-aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009157 ; owl:annotatedTarget "Sclerosis of the epiphysis of the proximal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009157 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009157 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "(2R)-2-ammoniobutanedioate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009157 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of pinky finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009157 ; owl:annotatedTarget "Ivory epiphysis of the proximal phalanx of the little finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "(2R)-2-ammoniosuccinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009158 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009158 ; owl:annotatedTarget "Enlarged end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009158 ; owl:annotatedTarget "Enlarged end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009158 ; owl:annotatedTarget "Enlarged end part of the innermost bone of pinky finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "D-aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009159 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009159 ; owl:annotatedTarget "Small end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29990 ; owl:annotatedTarget "D-aspartic acid monoanion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009159 ; owl:annotatedTarget "Small end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009159 ; owl:annotatedTarget "Small end part of the innermost bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009160 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009160 ; owl:annotatedTarget "Absent end part of the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009160 ; owl:annotatedTarget "Absent end part of the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009160 ; owl:annotatedTarget "Absent end part of the innermost bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009161 ; owl:annotatedTarget "Absence or underdevelopment (hypoplasia) of the middle phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009161 ; owl:annotatedTarget "Absent/small middle bone of pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009161 ; owl:annotatedTarget "Absent/underdeveloped middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009161 ; owl:annotatedTarget "Absent/underdeveloped middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009161 ; owl:annotatedTarget "Absent/underdeveloped middle bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009162 ; owl:annotatedTarget "Absence of the middle phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009162 ; owl:annotatedTarget "Absent middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009162 ; owl:annotatedTarget "Absent middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009162 ; owl:annotatedTarget "Absent middle bone of pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009164 ; owl:annotatedTarget "Abnormal calcification of the wrist bones" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Reaxys:506007" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009165 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 5th finger." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "Gmelin:327374" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009165 ; owl:annotatedTarget "Speckled calcifications in end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009165 ; owl:annotatedTarget "Speckled calcifications in end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009165 ; owl:annotatedTarget "Speckled calcifications in end part of the outermost bone of pinky finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "Reaxys:15801578" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009166 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009166 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009166 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009166 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of pinky finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "L-aspartate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009167 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "hydrogen L-aspartate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009167 ; owl:annotatedTarget "Irregular end part of the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009167 ; owl:annotatedTarget "Irregular end part of the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009167 ; owl:annotatedTarget "Irregular end part of the outermost bone of pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "(2S)-2-ammoniobutanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009168 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 5th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009168 ; owl:annotatedTarget "Bullet-shaped middle little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009168 ; owl:annotatedTarget "Bullet-shaped middle pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009168 ; owl:annotatedTarget "Bullet-shaped middle pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "(2S)-2-ammoniosuccinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009169 ; owl:annotatedTarget "Increased width of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009169 ; owl:annotatedTarget "Broad middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009169 ; owl:annotatedTarget "Broad middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009169 ; owl:annotatedTarget "Broad middle bone of pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "L-aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009170 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "L-aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009171 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the metacarpals. Thess epiphyses are located at the distal end of the metacarpals." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009171 ; owl:annotatedTarget "Triangular end part of the long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29991 ; owl:annotatedTarget "L-aspartic acid monoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009172 ; owl:annotatedTarget "Abnormality of the phalanges of the 4th (ring) finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009172 ; owl:annotatedTarget "Abnormal bones of 4th finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "ACETIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009173 ; owl:annotatedTarget "Curved appearance of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009173 ; owl:annotatedTarget "Curved middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009173 ; owl:annotatedTarget "Curved middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009173 ; owl:annotatedTarget "Curved middle bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009174 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009174 ; owl:annotatedTarget "Abnormality of the end part of the ring finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "Beilstein:4133557" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009175 ; owl:annotatedTarget "Patchy increase in bone density of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009175 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009175 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009175 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the pinky finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "Gmelin:327367" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009177 ; owl:annotatedTarget "Fusion of the proximal and middle phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009177 ; owl:annotatedTarget "Fused innermost and middle bones of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009177 ; owl:annotatedTarget "Fused innermost and middle bones of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009177 ; owl:annotatedTarget "Fused innermost and middle bones of pinky finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "Reaxys:4133557" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009178 ; owl:annotatedTarget "Fusion of the middle phalanx of the 5th finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009178 ; owl:annotatedTarget "Fused middle bones of little finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "(2S)-2-aminobutanedioate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009178 ; owl:annotatedTarget "Fused middle bones of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009178 ; owl:annotatedTarget "Fused middle bones of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009179 ; owl:annotatedTarget "Displacement of the 5th finger from its normal position." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "L-aspartate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009179 ; owl:annotatedTarget "Displaced little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009179 ; owl:annotatedTarget "Displaced pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009179 ; owl:annotatedTarget "Displaced pinky finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "L-aspartate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009180 ; owl:annotatedTarget "Displacement of the 5th finger towards the ulnar side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009182 ; owl:annotatedTarget "Triangular shaped middle phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009182 ; owl:annotatedTarget "Triangular shaped middle little finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "(2S)-2-aminosuccinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009182 ; owl:annotatedTarget "Triangular shaped middle pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009182 ; owl:annotatedTarget "Triangular shaped middle pinky finger bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Acetic acid" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29993 ; owl:annotatedTarget "L-aspartic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009183 ; owl:annotatedTarget "Chronic loss of joint motion in the 5th finger due to structural changes in non-bony tissue. The term camptodactyly of the 5th finger is used if the distal and/or proximal interphalangeal joints are affected." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009184 ; owl:annotatedTarget "Chronic loss of joint motion of the distal interphalangeal joint of the 5th finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009185 ; owl:annotatedTarget "Proximal interphalangeal (PIP) flexion deformity of the little finger. That is, the PIP joint of a little finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "Gmelin:327368" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009186 ; owl:annotatedTarget "Chronic loss of joint motion of the metacarpophalangeal joint of the 5th finger due to structural changes in non-bony tissue." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "Reaxys:14495011" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "(2R)-2-aminobutanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009187 ; owl:annotatedTarget "An abnormality of the distal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009187 ; owl:annotatedTarget "Bracket shaped end part of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009187 ; owl:annotatedTarget "Bracket shaped end part of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009187 ; owl:annotatedTarget "Bracket shaped end part of the outermost pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "D-aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009188 ; owl:annotatedTarget "A secondary ossification center in the distal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "D-aspartate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009189 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the metacarpals." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009189 ; owl:annotatedTarget "Fragmentation of end part of the long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009190 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the metacarpals." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "(2R)-2-aminosuccinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009190 ; owl:annotatedTarget "Irregular end part of the long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009191 ; owl:annotatedTarget "Sclerosis of the epiphyses of the metacarpals, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009191 ; owl:annotatedTarget "Increased bone density of end part of the long bone of hands" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29994 ; owl:annotatedTarget "D-aspartic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009192 ; owl:annotatedTarget "Absence or underdevelopment (hypoplasia) of the proximal phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009192 ; owl:annotatedTarget "Absent/small innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009192 ; owl:annotatedTarget "Absent/small innermost pinkie finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "acetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009192 ; owl:annotatedTarget "Absent/small innermost pinky finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009192 ; owl:annotatedTarget "Absent/underdeveloped innermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009193 ; owl:annotatedTarget "A pseudoepiphysis is a secondary ossification center distinct from the normal epiphysis. The normal metacarpal epiphyses are located at the distal ends of the metacarpal bones. Accessory epiphyses (which are also known as pseudoepiphyses) can also occasionally be observed at the proximal ends of the metacarpals, usually involving the 2nd metacarpal bone." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009193 ; owl:annotatedTarget "Accessory proximal metacarpal ossification centres" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29995 ; owl:annotatedTarget "2-aminobutanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009194 ; owl:annotatedTarget "Abnormally small size of the epiphyses located at the distal end of the metacarpals in respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009194 ; owl:annotatedTarget "Small end part of the long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29995 ; owl:annotatedTarget "aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009195 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the metacarpals." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009195 ; owl:annotatedTarget "Speckled calcifications in end part of the long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_29995 ; owl:annotatedTarget "aspartate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009196 ; owl:annotatedTarget "Absence of the epiphyses of the metacarpal bones, which are normally located at the distal ends of the metacarpals." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009196 ; owl:annotatedTarget "Absent end part of the long bone of hand" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009196 ; owl:annotatedTarget "Absent metacarpal ossification centre" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29995 ; owl:annotatedTarget "2-aminosuccinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009197 ; owl:annotatedTarget "An abnormality of the proximal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009197 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009197 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009197 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the pinky finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_29995 ; owl:annotatedTarget "aspartic acid dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009198 ; owl:annotatedTarget "Abnormality of the epiphysis of the distal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009198 ; owl:annotatedTarget "Abnormality of end part of the outermost bone of the little finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009198 ; owl:annotatedTarget "Abnormality of end part of the outermost bone of the pinkie finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009198 ; owl:annotatedTarget "Abnormality of end part of the outermost bone of the pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009199 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009199 ; owl:annotatedTarget "Irregular end part of the innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009199 ; owl:annotatedTarget "Irregular end part of the innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009199 ; owl:annotatedTarget "Irregular end part of the innermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009200 ; owl:annotatedTarget "A secondary ossification center in the proximal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "AcOH" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "Beilstein:1901470" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009201 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 5th finger." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "CAS:71-50-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009201 ; owl:annotatedTarget "Speckled calcifications in end part of the innnermost bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009201 ; owl:annotatedTarget "Speckled calcifications in end part of the innnermost bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009201 ; owl:annotatedTarget "Speckled calcifications in end part of the innnermost bone of the pinky finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "CAS:71-50-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009202 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009202 ; owl:annotatedTarget "Fragmentation of end part of the innermost bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009202 ; owl:annotatedTarget "Fragmentation of end part of the innermost bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009202 ; owl:annotatedTarget "Fragmentation of end part of the innermost bone of the pinky finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "Gmelin:1379" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009203 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the middle phalanx of the 5th finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009203 ; owl:annotatedTarget "Absent end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009203 ; owl:annotatedTarget "Absent end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009203 ; owl:annotatedTarget "Absent end part of the middle bone of the pinky finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "PMID:22211106" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009204 ; owl:annotatedTarget "An abnormality of the middle phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009204 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009204 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009204 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the pinky finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "PMID:22371380" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009205 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the middle phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "Reaxys:1901470" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009205 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009205 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009205 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the pinky finger" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "UM-BBD_compID:c0050" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009206 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009206 ; owl:annotatedTarget "Enlarged end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009206 ; owl:annotatedTarget "Enlarged end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009206 ; owl:annotatedTarget "Enlarged end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "acetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009207 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "CH3-COOH" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009207 ; owl:annotatedTarget "Fragmentation of end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009207 ; owl:annotatedTarget "Fragmentation of end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009207 ; owl:annotatedTarget "Fragmentation of end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "ACETATE ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009208 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009208 ; owl:annotatedTarget "Irregular end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009208 ; owl:annotatedTarget "Irregular end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009208 ; owl:annotatedTarget "Irregular end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "Azetat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009209 ; owl:annotatedTarget "Sclerosis of the epiphysis of the middle phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "CH3-COO(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009209 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009209 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009209 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "Ethanoat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009210 ; owl:annotatedTarget "A secondary ossification center in the middle phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "MeCO2 anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009211 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009211 ; owl:annotatedTarget "Small end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009211 ; owl:annotatedTarget "Small end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009211 ; owl:annotatedTarget "Small end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "acetic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009212 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009212 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009212 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30089 ; owl:annotatedTarget "ethanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009212 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009213 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the middle phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009213 ; owl:annotatedTarget "Triangular end part of the middle bone of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009213 ; owl:annotatedTarget "Triangular end part of the middle bone of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009213 ; owl:annotatedTarget "Triangular end part of the middle bone of the pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "isopropyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009214 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009214 ; owl:annotatedTarget "Absent end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "CH3CO2H" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "propan-2-yl" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "(CH3)2CH-" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009215 ; owl:annotatedTarget "An abnormality of the middle phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009215 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "-CH(CH3)2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009216 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the middle phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009216 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "1-methylethyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009217 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009217 ; owl:annotatedTarget "Enlarged end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "iPr" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009218 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30353 ; owl:annotatedTarget "valine side-chain" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009218 ; owl:annotatedTarget "Fragmentation of end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009219 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009219 ; owl:annotatedTarget "Irregular end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "2-methylpropan-1-ido" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009220 ; owl:annotatedTarget "Sclerosis of the epiphysis of the middle phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009220 ; owl:annotatedTarget "Increased bone density of end part of the middle ring finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "2-methylpropyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009221 ; owl:annotatedTarget "A secondary ossification center in the middle phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "isobutyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009222 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009222 ; owl:annotatedTarget "Small end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "E 260" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "(CH3)2CH-CH2-" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009223 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "-CH2-CH(CH3)2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009223 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "iBu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009224 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the middle phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009224 ; owl:annotatedTarget "Triangular end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30356 ; owl:annotatedTarget "leucine side-chain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009225 ; owl:annotatedTarget "Absence of the proximal phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009225 ; owl:annotatedTarget "Absent innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009225 ; owl:annotatedTarget "Absent innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009225 ; owl:annotatedTarget "Absent innermost bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009226 ; owl:annotatedTarget "Hypoplastic/small proximal phalanx of the fifth finger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009226 ; owl:annotatedTarget "Short innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009226 ; owl:annotatedTarget "Short innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009226 ; owl:annotatedTarget "Short innermost pinky finger bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009226 ; owl:annotatedTarget "Short proximal phalanx of the fifth finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009227 ; owl:annotatedTarget "Increased width of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009227 ; owl:annotatedTarget "Broad innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009227 ; owl:annotatedTarget "Broad innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009227 ; owl:annotatedTarget "Broad innermost pinky finger bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "Beilstein:1730720" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009228 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 5th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009228 ; owl:annotatedTarget "Bullet-shaped innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009228 ; owl:annotatedTarget "Bullet-shaped innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009228 ; owl:annotatedTarget "Bullet-shaped innermost pinky finger bone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "CAS:75-28-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009229 ; owl:annotatedTarget "Curved appearance of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009229 ; owl:annotatedTarget "Curved innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009229 ; owl:annotatedTarget "Curved innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009229 ; owl:annotatedTarget "Curved innermost bone of pinky finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "CAS:75-28-5" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "Gmelin:1301" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009230 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "E-260" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "PMID:24179026" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009231 ; owl:annotatedTarget "Patchy increase in bone density of the proximal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009231 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009231 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009231 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of pinky finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "PMID:24464945" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009232 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 5th finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009232 ; owl:annotatedTarget "Fused innermost bone of little finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "Reaxys:1730720" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009232 ; owl:annotatedTarget "Fused innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009232 ; owl:annotatedTarget "Fused innermost bone of pinky finger" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009233 ; owl:annotatedTarget "Triangular shaped proximal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "2-methylpropane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009233 ; owl:annotatedTarget "Triangular shaped innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009233 ; owl:annotatedTarget "Triangular shaped innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009233 ; owl:annotatedTarget "Triangular shaped innermost pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "isobutane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009234 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 5th finger with the 5th metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009234 ; owl:annotatedTarget "Fused innermost bone of little finger with 5th long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009234 ; owl:annotatedTarget "Fused innermost bone of pinkie finger with 5th long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009234 ; owl:annotatedTarget "Fused innermost bone of pinky finger with 5th long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009236 ; owl:annotatedTarget "Rhomboid or triangular shaped 5th (little) finger proximal phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009236 ; owl:annotatedTarget "Rhomboid or triangular shaped innermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009236 ; owl:annotatedTarget "Rhomboid or triangular shaped innermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009236 ; owl:annotatedTarget "Rhomboid or triangular shaped innermost bone of pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "(CH3)2CH-CH3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short 5th finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short fifth finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "E943b" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short fifth fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009237 ; owl:annotatedTarget "Short pinky finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30363 ; owl:annotatedTarget "R-600a" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009238 ; owl:annotatedTarget "Absent 5th (little) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009238 ; owl:annotatedTarget "Absent little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009238 ; owl:annotatedTarget "Absent pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009238 ; owl:annotatedTarget "Absent pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009239 ; owl:annotatedTarget "Absent/small outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009239 ; owl:annotatedTarget "Absent/small outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009239 ; owl:annotatedTarget "Absent/small outermost bone of pinky finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009239 ; owl:annotatedTarget "Absent/underdeveloped outermost bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009240 ; owl:annotatedTarget "Increased width of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009240 ; owl:annotatedTarget "Broad outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009240 ; owl:annotatedTarget "Broad outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009240 ; owl:annotatedTarget "Broad outermost pinky finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009240 ; owl:annotatedTarget "Wide outermost pinky finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "E260" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30411 ; owl:annotatedTarget "PMID:11371572" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009241 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 5th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009241 ; owl:annotatedTarget "Bullet-shaped outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009241 ; owl:annotatedTarget "Bullet-shaped outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009241 ; owl:annotatedTarget "Bullet-shaped outermost pinky finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30411 ; owl:annotatedTarget "PMID:15181872" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30411 ; owl:annotatedTarget "COBALAMIN" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009242 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30411 ; owl:annotatedTarget "Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-cobamide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009243 ; owl:annotatedTarget "Patchy increase in bone density of the distal phalanx of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009243 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009243 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009243 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30411 ; owl:annotatedTarget "cobalamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009244 ; owl:annotatedTarget "Fusion of the terminal/distal and middle phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009244 ; owl:annotatedTarget "Fused end and middle bones of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009244 ; owl:annotatedTarget "Fused end and middle bones of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009244 ; owl:annotatedTarget "Fused end and middle bones of pinky finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009244 ; owl:annotatedTarget "Fusion of the terminal and middle phalanges of the 5th finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009245 ; owl:annotatedTarget "Triangular shaped distal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009245 ; owl:annotatedTarget "Triangular shaped outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009245 ; owl:annotatedTarget "Triangular shaped outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009245 ; owl:annotatedTarget "Triangular shaped outermost pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "heme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009246 ; owl:annotatedTarget "Absence of the distal phalanx of the little (5th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009246 ; owl:annotatedTarget "Absent outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009246 ; owl:annotatedTarget "Absent outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009246 ; owl:annotatedTarget "Absent outermost pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "heme" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009247 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "heme" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009248 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Essigsaeure" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "hemes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009249 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "Haem" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "haem" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009250 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the distal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009250 ; owl:annotatedTarget "Absent end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "haem" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009251 ; owl:annotatedTarget "An abnormality of the distal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009251 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "haeme" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009252 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the distal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009252 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "hem" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009253 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009253 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30413 ; owl:annotatedTarget "hemos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009254 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the distal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009254 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009255 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009255 ; owl:annotatedTarget "Irregular end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009256 ; owl:annotatedTarget "Sclerosis of the epiphysis of the distal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009256 ; owl:annotatedTarget "Increased bone density of end part of the outermost ring finger bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Ethanoic acid" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "Beilstein:3536873" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009257 ; owl:annotatedTarget "A secondary ossification center in the distal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "Gmelin:559138" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009258 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009258 ; owl:annotatedTarget "Small end part of the outermost bone of the ring finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "PMID:12509893" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "Reaxys:3536873" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009259 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009259 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "4-aminobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009260 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the distal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009260 ; owl:annotatedTarget "Triangular end part of the outermost bone of ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "4-Amino-butyrat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009261 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009261 ; owl:annotatedTarget "Absent end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "4-Aminobutylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009262 ; owl:annotatedTarget "An abnormality of the proximal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009262 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "4-aminobutanoic acid ion (1-)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "4-aminobutyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009263 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the proximal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009263 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "gamma-aminobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009264 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009264 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Ethylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30566 ; owl:annotatedTarget "gamma-aminobutyrate anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009265 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009265 ; owl:annotatedTarget "Fragmentation of end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_305790 ; owl:annotatedTarget "(2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009266 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009266 ; owl:annotatedTarget "Irregular end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_305790 ; owl:annotatedTarget "2-Amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009267 ; owl:annotatedTarget "Sclerosis of the epiphysis of the proximal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009267 ; owl:annotatedTarget "Increased bone density of end part of the innermost ring finger bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_305790 ; owl:annotatedTarget "thyroxine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009268 ; owl:annotatedTarget "A secondary ossification center in the proximal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009269 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009269 ; owl:annotatedTarget "Small end part of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009270 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009270 ; owl:annotatedTarget "Speckled calcifications in end part of the innermost bone of ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009271 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the proximal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009271 ; owl:annotatedTarget "Triangular end part of the innermost bone of ring finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "Beilstein:1905970" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009272 ; owl:annotatedTarget "A small/hypoplastic or absent/aplastic 4th (ring) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009272 ; owl:annotatedTarget "Absent/small ring finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009272 ; owl:annotatedTarget "Absent/underdeveloped ring finger bone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "CAS:338-70-5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009273 ; owl:annotatedTarget "Displacement of the 4th finger from its normal position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009273 ; owl:annotatedTarget "Deviation of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "HOAc" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "Gmelin:2207" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "Reaxys:1905970" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009274 ; owl:annotatedTarget "Chronic loss of joint motion in the 4th finger due to structural changes in non-bony tissue. The term camptodactyly of the 4th finger is used if the distal and/or proximal interphalangeal joints are affected." . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "UM-BBD_compID:c0017" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009275 ; owl:annotatedTarget "Chronic loss of joint motion of the distal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "ethanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009276 ; owl:annotatedTarget "Chronic loss of joint motion of the proximal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue. That is, the PIP joint of a fourth finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "OXALATE ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009277 ; owl:annotatedTarget "Chronic loss of joint motion of the metacarpophalangeal joint of the 4th finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "ethanedioic acid, ion(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009278 ; owl:annotatedTarget "Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009278 ; owl:annotatedTarget "Ulnar deviation of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009279 ; owl:annotatedTarget "Displacement of the 4th finger towards the radial side (i.e., towards the thumb)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009279 ; owl:annotatedTarget "Radial deviation of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "ox" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009280 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the fourth finger, also known as the ring finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009280 ; owl:annotatedTarget "Short ring finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30623 ; owl:annotatedTarget "oxalate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009281 ; owl:annotatedTarget "Absent 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009281 ; owl:annotatedTarget "Absent ring finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009282 ; owl:annotatedTarget "Abnormality of the outermost bone of ring finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009283 ; owl:annotatedTarget "Abnormal middle bone of ring finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009283 ; owl:annotatedTarget "Abnormality of the middle phalanx of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "INS No. 260" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "Beilstein:2228514" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009284 ; owl:annotatedTarget "Abnormal innermost bone of ring finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009284 ; owl:annotatedTarget "Abnormality of the proximal phalanx of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009285 ; owl:annotatedTarget "Curved appearance of the phalanges of the 4th (ring) finger." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "CAS:300-30-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009285 ; owl:annotatedTarget "Curved ring finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009286 ; owl:annotatedTarget "Curved appearance of the distal phalanx of the 4th (ring) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009286 ; owl:annotatedTarget "Curved outermost ring finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "PMID:15206581" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009287 ; owl:annotatedTarget "Curved appearance of the middle phalanx of the 4th (ring) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009287 ; owl:annotatedTarget "Curved middle ring finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "PMID:24375501" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009288 ; owl:annotatedTarget "Curved innermost ring finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "PMID:9824273" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009289 ; owl:annotatedTarget "Absent/small outermost ring finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009289 ; owl:annotatedTarget "Absent/underdeveloped outermost ring finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "thyroxine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009290 ; owl:annotatedTarget "Hypoplastic/small distal phalanx of the fourth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009290 ; owl:annotatedTarget "Short outermost bone of ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009291 ; owl:annotatedTarget "Absence of the distal phalanx of the ring (4th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009291 ; owl:annotatedTarget "Absent outermost bone of ring finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "DL-Thyroxine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009292 ; owl:annotatedTarget "Increased width of the distal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009292 ; owl:annotatedTarget "Broad outermost bone of ring finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009292 ; owl:annotatedTarget "Wide outermost bone of ring finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009293 ; owl:annotatedTarget "Increased width of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009293 ; owl:annotatedTarget "Broad middle bone of the 4th finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30660 ; owl:annotatedTarget "Thx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009294 ; owl:annotatedTarget "Absence of the middle phalanx of the ring (4th) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009294 ; owl:annotatedTarget "Absent middle bone of 4th finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009295 ; owl:annotatedTarget "Hypoplastic/small middle phalanx of the 4th finger, also known as the ring finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "MeCO2H" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "Beilstein:2947040" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009295 ; owl:annotatedTarget "Short middle bone of 4th finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009296 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 4th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009296 ; owl:annotatedTarget "Bullet-shaped middle bone of the 4th finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "CAS:1034-10-2" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "Gmelin:419747" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009297 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the middle phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009298 ; owl:annotatedTarget "Absence of the proximal phalanx of the ring (4th) finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "PMID:15643926" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009298 ; owl:annotatedTarget "Absent innermost ring finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009299 ; owl:annotatedTarget "Absent/small middle ring finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009299 ; owl:annotatedTarget "Absent/underdeveloped middle ring finger bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "Reaxys:2947040" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009300 ; owl:annotatedTarget "Absent/small innermost ring finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009300 ; owl:annotatedTarget "Absent/underdeveloped innermost ring finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "thyronine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009301 ; owl:annotatedTarget "Hypoplastic/small proximal phalanx of the fourth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009301 ; owl:annotatedTarget "Short innermost bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009302 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 4th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009302 ; owl:annotatedTarget "Bullet-shaped outermost bone of ring finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30661 ; owl:annotatedTarget "O-(4-hydroxyphenyl)-DL-tyrosine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009303 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the distal phalanx of the 4th finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "PMID:28979944" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009304 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the distal phalanx of the fourth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009304 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "MeCOOH" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-D-glucopyranosyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009305 ; owl:annotatedTarget "Fusion of the terminal/distal and middle phalanges of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009305 ; owl:annotatedTarget "Fused outermost and middle bones of ring finger" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-D-glucosyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009306 ; owl:annotatedTarget "Triangular shaped distal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009306 ; owl:annotatedTarget "Triangular shaped outermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-D-glucopyranosyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009307 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the middle phalanx of the fourth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009307 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-D-glucosyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009308 ; owl:annotatedTarget "Fusion of the middle phalanx of the 4th finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009308 ; owl:annotatedTarget "Fused middle bone of ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-glucopyranosyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009309 ; owl:annotatedTarget "Triangular shaped middle phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009309 ; owl:annotatedTarget "Triangular shaped middle bone of the ring finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30697 ; owl:annotatedTarget "beta-glucosyl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009310 ; owl:annotatedTarget "Increased width of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009310 ; owl:annotatedTarget "Broad innermost ring finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009311 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 4th finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009311 ; owl:annotatedTarget "Bullet-shaped innermost ring finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009312 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal phalanx of the 4th finger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009313 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the proximal phalanx of the fourth finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009313 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the ring finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "Methanecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009314 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 4th finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009314 ; owl:annotatedTarget "Fused innermost bone of ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009315 ; owl:annotatedTarget "Triangular shaped proximal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009315 ; owl:annotatedTarget "Triangular shaped innermost bone of the 4th finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009315 ; owl:annotatedTarget "Triangular shaped innermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009316 ; owl:annotatedTarget "Abnormality of the phalanges of the 3rd (middle) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009316 ; owl:annotatedTarget "Abnormality of the middle finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009317 ; owl:annotatedTarget "Displacement of the 3rd finger from its normal position." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009317 ; owl:annotatedTarget "Deviated middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009318 ; owl:annotatedTarget "A small/hypoplastic or absent/aplastic 3rd (middle) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009318 ; owl:annotatedTarget "Absent/small middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009318 ; owl:annotatedTarget "Absent/underdeveloped middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009319 ; owl:annotatedTarget "Chronic loss of joint motion in the 3rd finger due to structural changes in non-bony tissue. The term camptodactyly of the 3rd finger is used if the distal and/or proximal interphalangeal joints are affected." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009320 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009320 ; owl:annotatedTarget "Abnormality of end part of the middle bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009321 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Beilstein:1099647" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009321 ; owl:annotatedTarget "Absent end part of the middle bone of the middle finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "CAS:103-82-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009322 ; owl:annotatedTarget "An abnormality of the middle phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009322 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the middle finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "acide acetique" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "CAS:103-82-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009323 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009323 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the middle finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "CAS:103-82-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009324 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009324 ; owl:annotatedTarget "Enlarged end part of the middle bone of the middle finger" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Drug_Central:4624" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Gmelin:68976" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009325 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the middle phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009325 ; owl:annotatedTarget "Fragmentation of end part of the middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:12147706" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009326 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the middle phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009326 ; owl:annotatedTarget "Irregular end part of the middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:12569987" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009327 ; owl:annotatedTarget "Sclerosis of the epiphysis of the middle phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009327 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:15057459" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009328 ; owl:annotatedTarget "A secondary ossification center in the middle phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:15506622" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009329 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009329 ; owl:annotatedTarget "Small end part of the middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:15646820" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:17622769" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009330 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009330 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the middle finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15366 ; owl:annotatedTarget "ethoic acid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:2083978" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009331 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009331 ; owl:annotatedTarget "Triangular end part of the middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:24587751" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009332 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:24631718" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009333 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:7544181" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PMID:7716788" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009334 ; owl:annotatedTarget "Abnormality of the middle part of the middle bone of the middle finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Reaxys:1099647" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009335 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009335 ; owl:annotatedTarget "Absent end part of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Phenylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009336 ; owl:annotatedTarget "An abnormality of the distal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009336 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "phenylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009337 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "2-PHENYLACETIC ACID" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009337 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "2-Phenylethanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009338 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009338 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the 3rd finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Benzeneacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009339 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009339 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Benzylformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009340 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009340 ; owl:annotatedTarget "Irregular end part of the outermost long bone of the middle finger" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "Omega-Phenylacetic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "PA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009341 ; owl:annotatedTarget "Sclerosis of the epiphysis of the distal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009341 ; owl:annotatedTarget "Increased bone density of end part of the outermost middle finger bone" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "alpha-toluic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009342 ; owl:annotatedTarget "A secondary ossification center in the distal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009342 ; owl:annotatedTarget "Pseudoepiphysis of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "benzeneacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009343 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009343 ; owl:annotatedTarget "Small end part of the outermost long bone of the middle finger" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30745 ; owl:annotatedTarget "omega-phenylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009344 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009344 ; owl:annotatedTarget "Speckled calcifications in end part of the outermost long bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009345 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009345 ; owl:annotatedTarget "Triangular end part of the outermost long bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009346 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009346 ; owl:annotatedTarget "Absent end part of innermost long bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009347 ; owl:annotatedTarget "An abnormality of the proximal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009347 ; owl:annotatedTarget "Bracket shaped end part of innermost long bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009348 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009348 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the middle finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Beilstein:1209246" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009349 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009349 ; owl:annotatedTarget "Enlarged end part of innermost long bone of the middle finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "CAS:64-18-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009350 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009350 ; owl:annotatedTarget "Fragmentation of end part of innermost long bone of the middle finger" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "CAS:64-18-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009351 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009351 ; owl:annotatedTarget "Irregular end part of innermost long bone of the middle finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "CAS:64-18-6" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Gmelin:1008" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009352 ; owl:annotatedTarget "Sclerosis of the epiphysis of the proximal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009352 ; owl:annotatedTarget "Increased bone density of end part of the innermost middle finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009353 ; owl:annotatedTarget "A secondary ossification center in the proximal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010040" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:12591956" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009354 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009354 ; owl:annotatedTarget "Small end part of innermost long bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:14637377" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009355 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009355 ; owl:annotatedTarget "Speckled calcifications in end part of innermost long bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:15811469" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009356 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009356 ; owl:annotatedTarget "Triangular end part of innermost long bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16120414" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009357 ; owl:annotatedTarget "Abnormality of the outermost bone of the 3rd finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16185830" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009358 ; owl:annotatedTarget "Abnormal innermost bone of middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009372 ; owl:annotatedTarget "Short index fingers and second toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16222862" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009374 ; owl:annotatedTarget "Increased width of the phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009374 ; owl:annotatedTarget "Broad little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009374 ; owl:annotatedTarget "Broad pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009374 ; owl:annotatedTarget "Broad pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16230297" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009375 ; owl:annotatedTarget "A fifth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009375 ; owl:annotatedTarget "Bullet-shaped little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009375 ; owl:annotatedTarget "Bullet-shaped pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009375 ; owl:annotatedTarget "Bullet-shaped pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16445901" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009376 ; owl:annotatedTarget "Aplasia/Hypoplasia of the phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009376 ; owl:annotatedTarget "Absent/small little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009376 ; owl:annotatedTarget "Absent/small pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009376 ; owl:annotatedTarget "Absent/small pinky finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009376 ; owl:annotatedTarget "Absent/underdeveloped pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:16465784" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:18034701" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009377 ; owl:annotatedTarget "Uneven increase in bone density of one or more of the phalanges of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009377 ; owl:annotatedTarget "Uneven increase in bone density in little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009377 ; owl:annotatedTarget "Uneven increase in bone density in pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009377 ; owl:annotatedTarget "Uneven increase in bone density in pinky finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:18397576" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009378 ; owl:annotatedTarget "Triangular shaped phalanges of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009378 ; owl:annotatedTarget "Triangular shaped little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009378 ; owl:annotatedTarget "Triangular shaped pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009378 ; owl:annotatedTarget "Triangular shaped pinky finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009379 ; owl:annotatedTarget "Rhomboid or triangular shaped 5th (little) finger distal phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009379 ; owl:annotatedTarget "Rhomboid or triangular shaped little finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22080171" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009379 ; owl:annotatedTarget "Rhomboid or triangular shaped pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009379 ; owl:annotatedTarget "Rhomboid or triangular shaped pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009380 ; owl:annotatedTarget "Aplasia of one or more fingers." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22280475" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009380 ; owl:annotatedTarget "Absent fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009381 ; owl:annotatedTarget "Abnormally short finger associated with developmental hypoplasia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009381 ; owl:annotatedTarget "Short finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22304812" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009381 ; owl:annotatedTarget "Stubby finger" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009381 ; owl:annotatedTarget "Stubby fingers" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22385261" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009382 ; owl:annotatedTarget "Absence of one or more epiphyses of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009382 ; owl:annotatedTarget "Absent end part of little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009382 ; owl:annotatedTarget "Absent end part of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009382 ; owl:annotatedTarget "Absent end part of pinky finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22447125" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009383 ; owl:annotatedTarget "An abnormality of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009383 ; owl:annotatedTarget "Bracket shaped end part of little finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22483350" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009383 ; owl:annotatedTarget "Bracket shaped end part of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009383 ; owl:annotatedTarget "Bracket shaped end part of pinky finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22499553" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009384 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the 5th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009384 ; owl:annotatedTarget "Cone-shaped end part of the little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009384 ; owl:annotatedTarget "Cone-shaped end part of the pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009384 ; owl:annotatedTarget "Cone-shaped end part of the pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22540994" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009385 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009385 ; owl:annotatedTarget "Enlarged end part of the little finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22606986" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009385 ; owl:annotatedTarget "Enlarged end part of the pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009385 ; owl:annotatedTarget "Enlarged end part of the pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:22622393" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009386 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009386 ; owl:annotatedTarget "Fragmentation of the end part of the little finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009386 ; owl:annotatedTarget "Fragmentation of the end part of the pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009386 ; owl:annotatedTarget "Fragmentation of the end part of the pinky finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:3946945" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009387 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009387 ; owl:annotatedTarget "Irregular end part of the little finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "PMID:7361809" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009387 ; owl:annotatedTarget "Irregular end part of the pinkie finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009387 ; owl:annotatedTarget "Irregular end part of the pinky finger bones" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Reaxys:1209246" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009388 ; owl:annotatedTarget "Sclerosis of the epiphyses of the 5th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009388 ; owl:annotatedTarget "Increased bone density of end part of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009388 ; owl:annotatedTarget "Increased bone density of end part of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009388 ; owl:annotatedTarget "Increased bone density of end part of the pinky finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "FORMIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009389 ; owl:annotatedTarget "A secondary ossification center in the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Formic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009390 ; owl:annotatedTarget "Abnormally small size of the epiphyses of the 5th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009390 ; owl:annotatedTarget "Small end part of little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009390 ; owl:annotatedTarget "Small end part of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009390 ; owl:annotatedTarget "Small end part of pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "formic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Acide formique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009391 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009391 ; owl:annotatedTarget "Speckled calcifications in end part of little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009391 ; owl:annotatedTarget "Speckled calcifications in end part of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009391 ; owl:annotatedTarget "Speckled calcifications in end part of pinky finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Ameisensaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009392 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the 5th finger of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009392 ; owl:annotatedTarget "Triangular end part of the little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009392 ; owl:annotatedTarget "Triangular end part of the pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009392 ; owl:annotatedTarget "Triangular end part of the pinky finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "H-COOH" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "HCO2H" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009393 ; owl:annotatedTarget "Absence of one or more epiphyses of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009393 ; owl:annotatedTarget "Absent end part of the ring finger bone" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "HCOOH" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009394 ; owl:annotatedTarget "An abnormality of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009394 ; owl:annotatedTarget "Bracket shaped end part of ring finger bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "Methanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009395 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the 4th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009395 ; owl:annotatedTarget "Cone-shaped end part of the ring finger bones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "aminic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "bilorin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009396 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009396 ; owl:annotatedTarget "Enlarged end part of the ring finger bones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "formylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009397 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009397 ; owl:annotatedTarget "Fragmentation of the end part of the ring finger bones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "hydrogen carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009398 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009398 ; owl:annotatedTarget "Irregular end part of the ring finger bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30751 ; owl:annotatedTarget "methoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009399 ; owl:annotatedTarget "Sclerosis of the epiphyses of the 4th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009399 ; owl:annotatedTarget "Increased bone density of end part of the ring finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009400 ; owl:annotatedTarget "A secondary ossification center in the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "Beilstein:506071" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009401 ; owl:annotatedTarget "Abnormally small size of the epiphyses of the 4th finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009401 ; owl:annotatedTarget "Small end part of ring finger bone" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "CAS:79-09-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009402 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009402 ; owl:annotatedTarget "Speckled calcifications in end part of ring finger bone" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "CAS:79-09-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009403 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the 4th finger of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009403 ; owl:annotatedTarget "Triangular end part of ring finger bone" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "CAS:79-09-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009404 ; owl:annotatedTarget "Increased width of the phalanges of the 4th finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009404 ; owl:annotatedTarget "Broad bones of ring finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "Gmelin:1821" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009405 ; owl:annotatedTarget "A fourth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009405 ; owl:annotatedTarget "Bullet-shaped of bone of ring finger" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010003" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009406 ; owl:annotatedTarget "Uneven increase in bone density of one or more of the phalanges of the fourth (ring) finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "PMID:15868474" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009406 ; owl:annotatedTarget "Uneven increase in bone density in ring finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009407 ; owl:annotatedTarget "Triangular shaped phalanges of the 4th finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009407 ; owl:annotatedTarget "Triangular shaped bone of ring finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "PMID:1628870" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009408 ; owl:annotatedTarget "Absent/small ring finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009408 ; owl:annotatedTarget "Absent/underdeveloped ring finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "PMID:16763906" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "Propionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009410 ; owl:annotatedTarget "Absence of the epiphyses of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009410 ; owl:annotatedTarget "Absent end part of middle finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "propanoic acid" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009411 ; owl:annotatedTarget "An abnormality of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009411 ; owl:annotatedTarget "Bracket shaped end part of middle finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "propionic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009412 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009412 ; owl:annotatedTarget "Cone-shaped end part of middle finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "CH3-CH2-COOH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009413 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "PA" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009413 ; owl:annotatedTarget "Enlarged end part of middle finger bone" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "PROPANOIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009414 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009414 ; owl:annotatedTarget "Fragmentation of end part of middle finger bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "Propanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009415 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009415 ; owl:annotatedTarget "Irregular end part of middle finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "Propionsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009416 ; owl:annotatedTarget "Sclerosis of the epiphyses of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009416 ; owl:annotatedTarget "Increased bone density of end part of the middle finger bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "acide propanoique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009417 ; owl:annotatedTarget "A secondary ossification center in the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "acide propionique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009418 ; owl:annotatedTarget "Abnormally small size of the epiphyses of the 3rd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "carboxyethane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009418 ; owl:annotatedTarget "Small end part of middle finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "ethanecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009419 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009419 ; owl:annotatedTarget "Speckled calcifications in end part of middle finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "ethylformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009420 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the 3rd finger of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009420 ; owl:annotatedTarget "Triangular end part of middle finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "metacetonic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009421 ; owl:annotatedTarget "Absent/small outermost middle finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009421 ; owl:annotatedTarget "Absent/underdeveloped outermost middle finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "methylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009422 ; owl:annotatedTarget "Increased width of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009422 ; owl:annotatedTarget "Broad outermost bone of middle finger" . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "propioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009423 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 3rd finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009423 ; owl:annotatedTarget "Bullet-shaped outermost bone of the middle finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "propoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009424 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30768 ; owl:annotatedTarget "pseudoacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009425 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the distal phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009425 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the 3rd finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009426 ; owl:annotatedTarget "Fusion of the terminal/distal and middle phalanges of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009426 ; owl:annotatedTarget "Fused outermost and middle bones of middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009427 ; owl:annotatedTarget "Triangular shaped distal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009427 ; owl:annotatedTarget "Triangular shaped outermost bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009428 ; owl:annotatedTarget "Curved appearance of the distal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009428 ; owl:annotatedTarget "Curved outermost bone of the 3rd finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009429 ; owl:annotatedTarget "Absence of the distal phalanx of the middle (3rd) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009429 ; owl:annotatedTarget "Absent of the outermost bone of the middle finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "CAS:7782-44-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009430 ; owl:annotatedTarget "Increased width of the middle phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009430 ; owl:annotatedTarget "Broad middle bone of middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009431 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 3rd finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009431 ; owl:annotatedTarget "Bullet-shaped middle bone of middle finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Beilstein:782061" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009432 ; owl:annotatedTarget "Curved appearance of the middle phalanx of the 3rd (middle) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009432 ; owl:annotatedTarget "Curved middle bone of the middle finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "CAS:77-92-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009433 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the middle phalanx of the 3rd finger." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "CAS:77-92-9" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "CAS:77-92-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009434 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the middle phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009434 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the middle finger" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Drug_Central:666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009435 ; owl:annotatedTarget "Fusion of the middle phalanx of the 3rd finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009435 ; owl:annotatedTarget "Fused middle bone of middle finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Gmelin:4240" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009436 ; owl:annotatedTarget "Triangular shaped middle phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009436 ; owl:annotatedTarget "Triangular shaped middle bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:11762832" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009437 ; owl:annotatedTarget "Absent/small middle bone of the middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009437 ; owl:annotatedTarget "Absent/underdeveloped middle bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009438 ; owl:annotatedTarget "Absence of the middle phalanx of the middle (3rd) finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:11782123" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009438 ; owl:annotatedTarget "Absent middle bone of middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009439 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the middle phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009439 ; owl:annotatedTarget "Short middle bone of middle finger" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "CAS:7782-44-7" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:11857437" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009440 ; owl:annotatedTarget "Increased width of the phalanges of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009440 ; owl:annotatedTarget "Wide bones of middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:14537820" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009441 ; owl:annotatedTarget "A third finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009441 ; owl:annotatedTarget "Bullet-shaped bones of middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:15311880" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009442 ; owl:annotatedTarget "Curved appearance of the phalanges of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009442 ; owl:annotatedTarget "Curved bones of middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:15934243" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009443 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the phalanges of the 3rd finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:16232627" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009444 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of one or more of the phalanges of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009444 ; owl:annotatedTarget "Uneven increase in bone density in middle finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:17357118" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009445 ; owl:annotatedTarget "Fusion of two or more bones of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009445 ; owl:annotatedTarget "Fused middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:17604395" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009446 ; owl:annotatedTarget "Triangular shaped phalanges of the 3rd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009446 ; owl:annotatedTarget "Triangular shaped bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:18298573" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009447 ; owl:annotatedTarget "Absent/small middle finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009447 ; owl:annotatedTarget "Absent/underdeveloped middle finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:18960216" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009450 ; owl:annotatedTarget "Increased width of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009450 ; owl:annotatedTarget "Broad innermost bone of middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009451 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 3rd finger is affected." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "CAS:7782-44-7" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:19288211" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009451 ; owl:annotatedTarget "Bullet-shaped innermost bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009452 ; owl:annotatedTarget "Curved appearance of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009452 ; owl:annotatedTarget "Curved innermost bone of middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:22115968" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:22192423" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009453 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal phalanx of the 3rd finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:22264346" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009454 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the proximal phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009454 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:22373571" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009455 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 3rd finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009455 ; owl:annotatedTarget "Fused innermost bone of middle finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "PMID:22509852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009456 ; owl:annotatedTarget "Triangular shaped proximal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009456 ; owl:annotatedTarget "Triangular shaped innermost bone of middle finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Reaxys:782061" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009457 ; owl:annotatedTarget "Absent/small innermost bone of middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009457 ; owl:annotatedTarget "Absent/underdeveloped innermost bone of middle finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "2-hydroxypropane-1,2,3-tricarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009458 ; owl:annotatedTarget "Absence of the proximal phalanx of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009458 ; owl:annotatedTarget "Absent innermost bone of middle finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "CITRIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009459 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the proximal phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009459 ; owl:annotatedTarget "Short innermost bone of middle finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Citric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009460 ; owl:annotatedTarget "Absent 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009460 ; owl:annotatedTarget "Absent middle finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "Gmelin:485" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "2-Hydroxy-1,2,3-propanetricarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009461 ; owl:annotatedTarget "Hypoplastic/small 3rd (middle) finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009461 ; owl:annotatedTarget "Short 3rd finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009461 ; owl:annotatedTarget "Short middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009462 ; owl:annotatedTarget "Displacement of the 3rd finger towards the radial side (i.e., towards the thumb)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009462 ; owl:annotatedTarget "Inward turned middle finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "2-Hydroxytricarballylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009463 ; owl:annotatedTarget "Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger)." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "3-Carboxy-3-hydroxypentane-1,5-dioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009464 ; owl:annotatedTarget "Displacement of the 2nd (index) finger towards the ulnar side." . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009465 ; owl:annotatedTarget "Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009465 ; owl:annotatedTarget "Finger bends toward pinky" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "Citronensaeure" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009466 ; owl:annotatedTarget "Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009467 ; owl:annotatedTarget "Displacement of the 2nd finger towards the radial side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009468 ; owl:annotatedTarget "Displacement of the 2nd finger from its normal position." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "E330" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009468 ; owl:annotatedTarget "Displaced index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30769 ; owl:annotatedTarget "H3cit" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009469 ; owl:annotatedTarget "Chronic loss of joint motion of the distal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009469 ; owl:annotatedTarget "Contracture of the outermost hinge joint of the 3rd finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009470 ; owl:annotatedTarget "Chronic loss of joint motion of the metacarpophalangeal joint of the 3rd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009471 ; owl:annotatedTarget "Chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009473 ; owl:annotatedTarget "Contractures of one ore more joints of the hands meaning chronic loss of joint motion due to structural changes in non-bony tissue." . [] a owl:Axiom ; rdfs:label "Contracture of hand joint" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0009473 ; owl:annotatedTarget "MEDDRA:10010821" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Beilstein:906770" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009477 ; owl:annotatedTarget "Fusion of the proximal and middle phalanges of the 4th finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009477 ; owl:annotatedTarget "Fused innermost and middle bone of fourth finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:10906528" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "CAS:107-92-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009478 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 4th finger with the 4th metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009478 ; owl:annotatedTarget "Fused innermost bone of ring finger with 4th long bone of hand" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "CAS:107-92-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009482 ; owl:annotatedTarget "Fusion of the proximal and middle phalanges of the 3rd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009482 ; owl:annotatedTarget "Fused of innermost and middle bones of middle finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "CAS:107-92-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009483 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 3rd finger with the 3rd metacarpal." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Gmelin:26242" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009483 ; owl:annotatedTarget "Fused innermost bones of middle finger with middle long bone of hand" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010004" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009484 ; owl:annotatedTarget "Displacement of the hand or of fingers of the hand from their normal position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009484 ; owl:annotatedTarget "Displaced hand or fingers of the hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:10736622" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009486 ; owl:annotatedTarget "An abnormal position of the hand in which the wrist is bent toward the radius (i.e., toward the thumb)." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:10956204" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009487 ; owl:annotatedTarget "Divergence of the longitudinal axis of the hand at the wrist in a posterior (ulnar) direction (i.e., towards the little finger)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009487 ; owl:annotatedTarget "Ulnar deviation of hands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009487 ; owl:annotatedTarget "Ulnar deviation of the hands" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:11201044" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009488 ; owl:annotatedTarget "Absence of the epiphyses of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009488 ; owl:annotatedTarget "Absent end part of index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:11208715" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:11238216" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009489 ; owl:annotatedTarget "An abnormality of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009489 ; owl:annotatedTarget "Bracket shaped end part of index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:16977326" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:11305323" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009490 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009490 ; owl:annotatedTarget "Cone-shaped end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:12068484" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009491 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the 2nd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009491 ; owl:annotatedTarget "Enlarged end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:13678314" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009492 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the 2nd finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:14962641" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009492 ; owl:annotatedTarget "Fragmentation of end part of the index finger" . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:1542095" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009493 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009493 ; owl:annotatedTarget "Irregular end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:15809727" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009494 ; owl:annotatedTarget "Sclerosis of the epiphyses of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009494 ; owl:annotatedTarget "Increased bone density of end part of the index finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:15810631" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009495 ; owl:annotatedTarget "A secondary ossification center in the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:15938880" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009496 ; owl:annotatedTarget "Abnormally small size of the epiphyses of the 2nd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009496 ; owl:annotatedTarget "Small end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:19318247" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009497 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd finger." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:19366864" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009497 ; owl:annotatedTarget "Speckled calcifications in end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:18210929" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:19703412" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009498 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the 2nd finger of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009498 ; owl:annotatedTarget "Triangular end part of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:21699495" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009499 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:22038864" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009500 ; owl:annotatedTarget "Abnormality of end part of the middle bone of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:22194341" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:22322557" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:22339023" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009502 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009502 ; owl:annotatedTarget "Absent end part of the outermost bone of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "PMID:22466881" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009503 ; owl:annotatedTarget "An abnormality of the distal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009503 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the index finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Reaxys:906770" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009504 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009504 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Butyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009505 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "butanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009505 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:18638417" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "butyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009506 ; owl:annotatedTarget "Fragmented appearance of the epiphysis of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009506 ; owl:annotatedTarget "Fragmentation of end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "1-butanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009507 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009507 ; owl:annotatedTarget "Irregular end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "1-butyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009508 ; owl:annotatedTarget "Sclerosis of the epiphysis of the distal phalanx of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009508 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "1-propanecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009509 ; owl:annotatedTarget "A secondary ossification center in the distal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "4:0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009510 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "BUTANOIC ACID" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009510 ; owl:annotatedTarget "Small end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Butanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009511 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009511 ; owl:annotatedTarget "Speckled calcifications in end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Butanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009512 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009512 ; owl:annotatedTarget "Triangular end part of the outermost bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "Buttersaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009513 ; owl:annotatedTarget "Missing end part of the middle long bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "C4:0" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:19840863" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "CH3-[CH2]2-COOH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009514 ; owl:annotatedTarget "An abnormality of the middle phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009514 ; owl:annotatedTarget "Bracket shaped end part of the middle long bone of the index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "acide butanoique" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009515 ; owl:annotatedTarget "Cone-shaped end part of the middle long bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "acide butyrique" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009516 ; owl:annotatedTarget "Enlarged end part of the middle bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "butanic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009517 ; owl:annotatedTarget "Fragmentation of end part of the middle long bone of the index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "butoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009518 ; owl:annotatedTarget "Irregular end part of the middle long bone of the index finger" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "ethylacetic acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "n-butanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009519 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009520 ; owl:annotatedTarget "A secondary ossification center in the middle phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "n-butyric acid" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "propanecarboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009521 ; owl:annotatedTarget "Small end part of the innermost long bone of index finger" . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30772 ; owl:annotatedTarget "propylformic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009522 ; owl:annotatedTarget "Speckled calcifications in end part of the middle bone of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:7710549" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009523 ; owl:annotatedTarget "Triangular end part of the middle bone of the index finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009524 ; owl:annotatedTarget "Absent end part of innermost long bone of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009525 ; owl:annotatedTarget "An abnormality of the proximal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Beilstein:773837" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009525 ; owl:annotatedTarget "Bracket shaped end part of innermost long bone of index finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "CAS:142-62-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009526 ; owl:annotatedTarget "Cone-shaped end part of innermost long bone of index finger" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "CAS:142-62-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009527 ; owl:annotatedTarget "Enlarged end part of innermost long bone of index finger" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "CAS:142-62-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009528 ; owl:annotatedTarget "Fragmentation of end part of innermost long bone of index finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Gmelin:185066" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009529 ; owl:annotatedTarget "Irregular end part of innermost long bone of index finger" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01010006" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "PMID:10685018" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009530 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009531 ; owl:annotatedTarget "A secondary ossification center in the proximal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "PMID:9463773" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "PMID:1556177" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "PMID:24357269" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009532 ; owl:annotatedTarget "Small end part of proximal long bond of index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "PMID:24924750" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009533 ; owl:annotatedTarget "Speckled calcifications in end part of the innermost long bone of index finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Reaxys:773837" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009534 ; owl:annotatedTarget "Triangular end part of innermost long bone of index finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "HEXANOIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009535 ; owl:annotatedTarget "Absent 2nd (index) finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009535 ; owl:annotatedTarget "Absent index finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Hexanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009536 ; owl:annotatedTarget "Hypoplasia of the second finger, also known as the index finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009536 ; owl:annotatedTarget "Short index finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009536 ; owl:annotatedTarget "Short index fingers" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "hexanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009537 ; owl:annotatedTarget "Chronic loss of joint motion in the 2nd finger due to structural changes in non-bony tissue. The term camptodactyly of the 2nd finger is used if the distal and/or proximal interphalangeal joints are affected." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "1-hexanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009538 ; owl:annotatedTarget "Chronic loss of joint motion of the distal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "1-pentanecarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009539 ; owl:annotatedTarget "Chronic loss of joint motion of the metacarpophalangeal joint of the 2nd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "6:0" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "dioxygen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "C6:0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009540 ; owl:annotatedTarget "Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009541 ; owl:annotatedTarget "Abnormality of the phalanges of the 2nd (index) finger." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "CH3-[CH2]4-COOH" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009541 ; owl:annotatedTarget "Abnormal index finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009542 ; owl:annotatedTarget "Abnormality of the outermost bone of the 2nd finger" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Hexanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009543 ; owl:annotatedTarget "Abnormal middle index finger bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Hexylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009544 ; owl:annotatedTarget "Abnormal innermost index finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "Pentanecarboxylic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009545 ; owl:annotatedTarget "Fused index finger bones" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "butylacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009546 ; owl:annotatedTarget "Triangular shaped phalanges of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009546 ; owl:annotatedTarget "Triangular bones of index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "caproic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009547 ; owl:annotatedTarget "Wide index finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009548 ; owl:annotatedTarget "A second finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "capronic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009548 ; owl:annotatedTarget "Bullet-shaped index finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009549 ; owl:annotatedTarget "Curved index finger bones" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "hexoic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "n-Caproic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "Disauerstoff" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "n-hexanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009551 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of one or more of the phalanges of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009551 ; owl:annotatedTarget "Uneven increase in bone density in index finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "n-hexoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009552 ; owl:annotatedTarget "Absent/small index finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009552 ; owl:annotatedTarget "Absent/underdeveloped index finger bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "n-hexylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009553 ; owl:annotatedTarget "The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009553 ; owl:annotatedTarget "Abnormality of the hairline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009554 ; owl:annotatedTarget "An tongue-like extension of hair towards the cheeks, in which hair growth extends in front of the ear to the lateral cheekbones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009554 ; owl:annotatedTarget "Hair growing down to cheek" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009554 ; owl:annotatedTarget "Projection of scalp hair onto lateral cheek" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "pentiformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Underdevelopment of the pharynx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Small pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Decreased size of pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Underdevelopment of pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Decreased diameter of pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Decreased length of pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Decreased volume of pharynx" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30776 ; owl:annotatedTarget "pentylformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Decreased width of pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009555 ; owl:annotatedTarget "Hypotrophic pharynx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009556 ; owl:annotatedTarget "Absence of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009556 ; owl:annotatedTarget "Absent shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009556 ; owl:annotatedTarget "Absent shinbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009557 ; owl:annotatedTarget "Absent/small outermost index finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009557 ; owl:annotatedTarget "Absent/underdeveloped outermost index finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009558 ; owl:annotatedTarget "Increased width of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009558 ; owl:annotatedTarget "Wide outermost bone of the index finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "Beilstein:1751370" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009559 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 2nd finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009559 ; owl:annotatedTarget "Bullet-shaped outermost bone of the index finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "CAS:141-82-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009560 ; owl:annotatedTarget "Curved appearance of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009560 ; owl:annotatedTarget "Curved outermost bone of the index finger" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "CAS:141-82-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009561 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the distal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009561 ; owl:annotatedTarget "Osteolytic defects of the outermost bone of the 2nd finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "E 948" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "CAS:141-82-2" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "Gmelin:2550" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009562 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the distal phalanx of the second finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009562 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the 2nd finger" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170041" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009563 ; owl:annotatedTarget "Fusion of the terminal/distal and middle phalanges of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009563 ; owl:annotatedTarget "Fused outermost and middle index finger bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009564 ; owl:annotatedTarget "Triangular shaped distal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009564 ; owl:annotatedTarget "Triangular shaped outermost bone of the 2nd finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009565 ; owl:annotatedTarget "Absent outermost index finger bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "Reaxys:1751370" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009566 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the distal phalanx of the second finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009566 ; owl:annotatedTarget "Short outermost bone of the index finger" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "MALONIC ACID" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009568 ; owl:annotatedTarget "Absent/small middle index finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009568 ; owl:annotatedTarget "Absent/underdeveloped middle index finger bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "Malonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009569 ; owl:annotatedTarget "Increased width of the middle phalanx of the second finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009569 ; owl:annotatedTarget "Broad middle bone of the index finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "propanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009570 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 2nd finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009570 ; owl:annotatedTarget "Bullet-shaped middle bone of index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "H2malo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009571 ; owl:annotatedTarget "Curved appearance of the middle phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009571 ; owl:annotatedTarget "Curved middle bone of the index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "HOOC-CH2-COOH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009572 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the middle phalanx of the 2nd finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "E-948" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30794 ; owl:annotatedTarget "Propanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009573 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the middle phalanx of the second finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009573 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009574 ; owl:annotatedTarget "Fusion of the middle phalanx of the 2nd finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009574 ; owl:annotatedTarget "Fused middle bone of index finger" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "Beilstein:3904186" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009575 ; owl:annotatedTarget "Triangular shaped middle phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009575 ; owl:annotatedTarget "Triangular shaped middle bone of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009576 ; owl:annotatedTarget "Absence of the middle phalanx of the index (2nd) finger." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "Gmelin:324637" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009576 ; owl:annotatedTarget "Absent middle bone of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009577 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the middle phalanx of the second finger, also known as the index finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009577 ; owl:annotatedTarget "Short middle bone of index finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "carboxyacetate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009579 ; owl:annotatedTarget "Fusion of the proximal and middle phalanges of the 2nd finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "HOOC-CH2-COO(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009579 ; owl:annotatedTarget "Fused innermost and middle index finger bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009580 ; owl:annotatedTarget "Absent/small innermost index finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009580 ; owl:annotatedTarget "Absent/underdeveloped innermost index finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "Hmalo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009581 ; owl:annotatedTarget "Increased width of the proximal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009581 ; owl:annotatedTarget "Wide innermost bone of index finger" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30795 ; owl:annotatedTarget "Malonic acid, conjugate base" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009582 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 2nd finger is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009582 ; owl:annotatedTarget "Bullet-shaped innermost bone of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009583 ; owl:annotatedTarget "Curved appearance of the proximal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009583 ; owl:annotatedTarget "Curved innermost bone of index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "E948" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009584 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal phalanx of the 2nd finger." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "Beilstein:3589340" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009585 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the proximal phalanx of the second finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009585 ; owl:annotatedTarget "Uneven increase in bone density in innermost index finger bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "Gmelin:335122" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009586 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 2nd finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009586 ; owl:annotatedTarget "Fused innermost bone of index finger" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "Reaxys:3589340" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009587 ; owl:annotatedTarget "Triangular shaped proximal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009587 ; owl:annotatedTarget "Triangular shaped innermost bone of index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009588 ; owl:annotatedTarget "A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma) is a benign, usually slow-growing tumor that develops from the VIIIth cranial nerve supplying the inner ear." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009588 ; owl:annotatedTarget "Vestibular Schwann cell tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009589 ; owl:annotatedTarget "A bilateral vestibular schwannoma (acoustic neurinoma)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009590 ; owl:annotatedTarget "A unilateral vestibular schwannoma (acoustic neurinoma)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "Tetradecanoate" . [] oboInOwl:hasDbXref , "PMID:30726044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009591 ; owl:annotatedTarget "Any structural anomaly of the vestibulocochlear nerve. The vestibulocochlear nerve consists of the vestibular and cochlear nerves, also known as cranial nerve eight (CN VIII). Each nerve has distinct nuclei within the brainstem. The vestibular nerve is primarily responsible for maintaining body balance and eye movements, while the cochlear nerve is responsible for hearing." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009592 ; owl:annotatedTarget "Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009593 ; owl:annotatedTarget "The presence of a peripheral schwannoma." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "tetradecanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009594 ; owl:annotatedTarget "A hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009595 ; owl:annotatedTarget "Neurofibromas present in a smaller number than usually seen in neurofibromatosis type 1." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "tetradecanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009596 ; owl:annotatedTarget "Absence of the proximal phalanx of the 2nd finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009596 ; owl:annotatedTarget "Absent innermost bone of index finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "1-tetradecanecarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009597 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the proximal phalanx of the second finger." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "CH3-[CH2]12-COO(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009598 ; owl:annotatedTarget "Fusion of the proximal phalanx of the 2nd finger with the 2nd metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009598 ; owl:annotatedTarget "Fused innermost bone of index finger with 2nd long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "O2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "myristate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009599 ; owl:annotatedTarget "Abnormality of one or all of the epiphyses of the proximal, and distal phalanges of the thumb and/or the 1st metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009599 ; owl:annotatedTarget "Abnormality of end part of thumb long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "n-tetradecan-1-oate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "n-tetradecoate" . [] oboInOwl:hasDbXref , "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009600 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the thumb joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin. The term camptodactyly is used if the distal and/or proximal interphalangeal joints are affected." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009601 ; owl:annotatedTarget "Hypoplastic/small or absent thumb." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30807 ; owl:annotatedTarget "tetradecoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009601 ; owl:annotatedTarget "Absent/small thumb" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009601 ; owl:annotatedTarget "Absent/underdeveloped thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009602 ; owl:annotatedTarget "A structural anomaly of one or more phalanges of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009602 ; owl:annotatedTarget "Abnormality of the thumb bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009603 ; owl:annotatedTarget "Displacement of the thumb from its normal position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009603 ; owl:annotatedTarget "Abnormal thumb placement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009606 ; owl:annotatedTarget "Complete duplication of the distal phalanx of the thumb. On x-ray two separate bones appear side to side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009606 ; owl:annotatedTarget "Complete duplication of outermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009608 ; owl:annotatedTarget "Complete duplication of the proximal phalanx of the thumb. On x-ray two separate bones appear side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009608 ; owl:annotatedTarget "Complete duplication of the innermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009609 ; owl:annotatedTarget "Partail or complete duplication of the first metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009609 ; owl:annotatedTarget "Partial/complete duplication of the 1st long bone of hand" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30839 ; owl:annotatedTarget "Beilstein:3651747" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009611 ; owl:annotatedTarget "Partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009611 ; owl:annotatedTarget "Notched outermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009612 ; owl:annotatedTarget "Complete or partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009612 ; owl:annotatedTarget "Duplication of the outermost bone of the thumb" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30839 ; owl:annotatedTarget "CAS:73-97-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009613 ; owl:annotatedTarget "Complete or partial duplication of the proximal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009613 ; owl:annotatedTarget "Notched innermost bone of thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009614 ; owl:annotatedTarget "This term applies if the proximal phalanx of the thumb is partially duplicated. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009614 ; owl:annotatedTarget "Notched thumb bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "O2" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30839 ; owl:annotatedTarget "Gmelin:464718" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009615 ; owl:annotatedTarget "Complete duplication of the first metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009615 ; owl:annotatedTarget "Complete duplication of the first long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30839 ; owl:annotatedTarget "2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009616 ; owl:annotatedTarget "Partial duplication of the first metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009616 ; owl:annotatedTarget "Notched first long bone of hand" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30839 ; owl:annotatedTarget "orotate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009617 ; owl:annotatedTarget "Any anomaly of the distal phalanx of thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009617 ; owl:annotatedTarget "Abnormality of the outermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009618 ; owl:annotatedTarget "An anomaly of the shape or form of the proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009618 ; owl:annotatedTarget "Abnormal innermost thumb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0009618 ; owl:annotatedTarget "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009622 ; owl:annotatedTarget "Insertion of thumb at a more distal location than normal." . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009623 ; owl:annotatedTarget "Proximal mislocalization of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009623 ; owl:annotatedTarget "Attachment of thumb close to wrist" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30848 ; owl:annotatedTarget "CAS:3106-08-9" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009624 ; owl:annotatedTarget "Chronic loss of joint motion of the carpometacarpal joint of the thumb due to structural changes in non-bony tissue. This joint is formed by the first metacarpal and the trapezial bone and is also called Articulatio carpometacarpalis pollicis, carpometacarpal articulation of thumb, carpometacarpal joint of thumb or first carpometacarpal articulation. Seldom referred to as thumb saddle joint." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30848 ; owl:annotatedTarget "7,9-dihydro-1H-purine-2,6,8(3H)-trione, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009625 ; owl:annotatedTarget "Chronic loss of joint motion of the metacarpophalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio metacarpophalangealis pollicis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30848 ; owl:annotatedTarget "uric acid monoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009626 ; owl:annotatedTarget "Chronic loss of joint motion of the interphalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio interphalangealis pollicis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30848 ; owl:annotatedTarget "uric acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009629 ; owl:annotatedTarget "This term applies if the proximal phalanx of the thumb is either small/hypoplastic or absent. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009629 ; owl:annotatedTarget "Absent/small innermost thumb bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009629 ; owl:annotatedTarget "Absent/underdeveloped innermost thumb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009630 ; owl:annotatedTarget "Increased width of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009630 ; owl:annotatedTarget "Broad innermost thumb bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "O2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009631 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the thumb is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009631 ; owl:annotatedTarget "Bullet-shaped innermost thumb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009632 ; owl:annotatedTarget "A deviation from the normal straight shape of the proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009632 ; owl:annotatedTarget "Curved innermost thumb bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "Beilstein:1756084" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009633 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal phalanx of the thumb." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "CAS:516-05-2" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "CAS:516-05-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009634 ; owl:annotatedTarget "An uneven increase in bone density of the proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009634 ; owl:annotatedTarget "Uneven increase in bone density in the innermost thumb bone" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "CAS:516-05-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009635 ; owl:annotatedTarget "Fusion of a phalanx of the thumb with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009635 ; owl:annotatedTarget "Fusion of thumb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009636 ; owl:annotatedTarget "Triangular shaped proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009636 ; owl:annotatedTarget "Triangular innermost thumb bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "Gmelin:50008" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009637 ; owl:annotatedTarget "Absence of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009637 ; owl:annotatedTarget "Absent innermost thumb bone" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170118" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009638 ; owl:annotatedTarget "Hypoplastic (short) proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009638 ; owl:annotatedTarget "Short proximal thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:11673368" . [] oboInOwl:hasDbXref , "PMID:26571461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009640 ; owl:annotatedTarget "Fusion of the proximal phalanx of the thumb with the 1st metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009640 ; owl:annotatedTarget "Fusion of the innermost bone of the thumb with the 1st long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009641 ; owl:annotatedTarget "Absent/small outermost thumb bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009641 ; owl:annotatedTarget "Absent/underdeveloped outermost thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:15770414" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009642 ; owl:annotatedTarget "Increased width of the distal phalanx of thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009642 ; owl:annotatedTarget "Broad outermost bone of the thumb" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009642 ; owl:annotatedTarget "Wide outermost bone of thumb" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "OXYGEN MOLECULE" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009643 ; owl:annotatedTarget "Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the thumb is affected." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009643 ; owl:annotatedTarget "Bullet-shaped outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21478039" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009644 ; owl:annotatedTarget "A deviation from the normal straight shape of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009644 ; owl:annotatedTarget "Curved outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21652239" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009645 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009645 ; owl:annotatedTarget "Osteolytic defects of the outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21687976" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21748409" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009646 ; owl:annotatedTarget "An uneven increase in bone density of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009646 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009648 ; owl:annotatedTarget "Triangular shaped distal phalanx of the thumb. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009648 ; owl:annotatedTarget "Triangular shaped outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21802231" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009649 ; owl:annotatedTarget "Absence of the distal/terminal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009649 ; owl:annotatedTarget "Absence of the outermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009649 ; owl:annotatedTarget "Aplasia of the outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:21896502" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009650 ; owl:annotatedTarget "Hypoplastic (short) distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009650 ; owl:annotatedTarget "Short outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22104738" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009652 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the thumb, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009652 ; owl:annotatedTarget "Bullet-shaped thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22233538" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009653 ; owl:annotatedTarget "A deviation from the normal straight shape of a thumb phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009653 ; owl:annotatedTarget "Curved thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22301932" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009654 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of one or more phalanges of the thumb." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "Oxygen" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22332180" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009655 ; owl:annotatedTarget "An uneven increase in bone density of one or more of the phalanges of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009655 ; owl:annotatedTarget "Uneven increase in bone density in thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22377700" . [] oboInOwl:hasDbXref , "PMID:22379556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009656 ; owl:annotatedTarget "Congenital fusion (ankylosis) of the interphalangeal joint of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009656 ; owl:annotatedTarget "Fused thumb bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009657 ; owl:annotatedTarget "Abnormal shape of one or more phalanges of the thumb such that affected phalanges resemble a triangle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009657 ; owl:annotatedTarget "Triangular shaped thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22422209" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009658 ; owl:annotatedTarget "Absent/small thumb bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009658 ; owl:annotatedTarget "Absent/underdeveloped thumb bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22424943" . [] oboInOwl:hasDbXref "PMID:probinson" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009659 ; owl:annotatedTarget "The absence of a phalangeal segment of a thumb." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009659 ; owl:annotatedTarget "Partial absence of thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009660 ; owl:annotatedTarget "Hypoplastic (short) thumb phalanx." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22509143" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009660 ; owl:annotatedTarget "Short thumb bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22537172" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009662 ; owl:annotatedTarget "Abnormality of the epiphysis of the distal phalanx of the thumb. This epiphysis is located on the proximal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009662 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009663 ; owl:annotatedTarget "This term applies if the epiphysis of the proximal phalanx of the thumb, which is located at the proximal end of the phalanx, does not appear in concordance with gender and age dependant norms as seen on x-rays. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009663 ; owl:annotatedTarget "Abnormality of end part of thumb innermost long bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "Reaxys:1756084" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009664 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009664 ; owl:annotatedTarget "Absent end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "METHYLMALONIC ACID" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "Methylmalonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009665 ; owl:annotatedTarget "An abnormality of the proximal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009665 ; owl:annotatedTarget "Bracket shaped end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "[OO]" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "methylpropanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009666 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the proximal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009666 ; owl:annotatedTarget "Cone-shaped end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "1,1-Ethanedicarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009667 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009667 ; owl:annotatedTarget "Enlarged end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "2-methylmalonic acid" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "Isosuccinic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009668 ; owl:annotatedTarget "Epiphysis of the proximal phalanx of the thumb having multiple bony fragments." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009668 ; owl:annotatedTarget "Fragmentation of end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30860 ; owl:annotatedTarget "alpha-methylmalonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009669 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009669 ; owl:annotatedTarget "Irregular end part of thumb innermost long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009670 ; owl:annotatedTarget "Sclerosis of the epiphysis of the proximal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009670 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009671 ; owl:annotatedTarget "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the proximal phalanx of the thumb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009672 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009672 ; owl:annotatedTarget "Small end part of thumb innermost long bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30861 ; owl:annotatedTarget "Beilstein:5499681" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30861 ; owl:annotatedTarget "Gmelin:142213" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009673 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009673 ; owl:annotatedTarget "Speckled calcifications in end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "dioxygene" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30861 ; owl:annotatedTarget "Reaxys:5499681" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009674 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the proximal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009674 ; owl:annotatedTarget "Triangular end part of thumb innermost long bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30861 ; owl:annotatedTarget "2-carboxypropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009675 ; owl:annotatedTarget "Absence of the epiphysis located at the proximal end of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009675 ; owl:annotatedTarget "Absent end part of thumb outermost long bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30879 ; owl:annotatedTarget "Alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009676 ; owl:annotatedTarget "An abnormality of the distal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30879 ; owl:annotatedTarget "alcohols" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009676 ; owl:annotatedTarget "Bracket shaped end part of thumb outermost long bone" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30879 ; owl:annotatedTarget "an alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009677 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the distal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009677 ; owl:annotatedTarget "Cone-shaped end part of thumb outermost long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009678 ; owl:annotatedTarget "Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009678 ; owl:annotatedTarget "Enlarged end part of thumb outermost long bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "Beilstein:1721909" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009679 ; owl:annotatedTarget "Epiphysis of the distal phalanx of the thumb having multiple bony fragments." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009679 ; owl:annotatedTarget "Fragmentation of end part thumb outermost long bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "Gmelin:83165" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "glucitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009680 ; owl:annotatedTarget "Uneven radiographic opacity of the epiphysis of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009680 ; owl:annotatedTarget "Irregular end part of thumb outermost bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "Sorbitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009681 ; owl:annotatedTarget "Sclerosis of the epiphysis of the distal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009681 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the thumb" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15379 ; owl:annotatedTarget "molecular oxygen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "gulitol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009682 ; owl:annotatedTarget "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009682 ; owl:annotatedTarget "Pseudoepiphysis of the outermost bone of the thumb" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30911 ; owl:annotatedTarget "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009683 ; owl:annotatedTarget "Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009683 ; owl:annotatedTarget "Small end part of thumb outermost bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009684 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009684 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost thumb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009685 ; owl:annotatedTarget "A triangular appearance of the epiphysis of the distal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009685 ; owl:annotatedTarget "Triangular end part of thumb outermost bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009685 ; owl:annotatedTarget "Triangular epiphysis of the outermost bone of the thumb" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "Beilstein:1705689" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009686 ; owl:annotatedTarget "Absence of one or more epiphyses of the thumb." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "CAS:328-50-7" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009687 ; owl:annotatedTarget "An abnormality of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009687 ; owl:annotatedTarget "Bracket shaped end part of the thumb bone" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "CAS:328-50-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009688 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the thumb, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009688 ; owl:annotatedTarget "Cone-shaped end part of thumb long bone" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "CAS:328-50-7" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "Gmelin:602480" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009689 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the thumb with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009689 ; owl:annotatedTarget "Enlarged end part of thumb long bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009690 ; owl:annotatedTarget "Epiphysis of the thumb having multiple bony fragments." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009690 ; owl:annotatedTarget "Fragmentation of end part of long bone of thumb" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:18990406" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009691 ; owl:annotatedTarget "Uneven radiographic opacity of the one or more epiphyses of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009691 ; owl:annotatedTarget "Irregular end part of thumb long bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:20155414" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009692 ; owl:annotatedTarget "Sclerosis of one or more of the epiphyses of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:20200292" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009692 ; owl:annotatedTarget "Increased bone density of end part of the thumb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009693 ; owl:annotatedTarget "A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of one or more phalanges of the thumb." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:20583149" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:20636327" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009694 ; owl:annotatedTarget "Abnormally small size of one or more of the epiphyses of the thumb with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009694 ; owl:annotatedTarget "Small end part of thumb long bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "PMID:21964641" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009695 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more of the epiphyses of the thumb." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009695 ; owl:annotatedTarget "Speckled calcifications in end part of thumb bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "Reaxys:1705689" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009696 ; owl:annotatedTarget "Triangular end part of the thumb bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "2-oxopentanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009697 ; owl:annotatedTarget "Chronic loss of joint motion in one or more distal interphalangeal joints of the fingers." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "2-Ketoglutaric acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "Oxoglutaric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009700 ; owl:annotatedTarget "An abnormal union between bones or parts of bones of the fingers. The synonymous term \"symphalangism of the hand\" may be translated as fusions of bones of varying digree, that involve at least one phalangeal bone of the hand. If bony fusions are referred to as \"Symphalangism\" the fusion occurs in a proximo-distal axis. Fusions of bones of the fingers in a radio-ulnar axis are referred to as \"bony\" Syndactyly." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009700 ; owl:annotatedTarget "Fused finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009700 ; owl:annotatedTarget "Symphalangism of the hand" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "alpha-Ketoglutaric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009701 ; owl:annotatedTarget "Fusion involving two or more metacarpal bones (A synostosis of the first metacarpal and the proximal phalanx of the thumb can also be observed, note that the first metacarpal bone corresponds to a proximal phalanx)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009701 ; owl:annotatedTarget "Fused long bones of hand" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30915 ; owl:annotatedTarget "alpha-ketoglutaric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009702 ; owl:annotatedTarget "Synostosis (bony fusion) involving one or more bones of the carpus (scaphoid, lunate, triquetrum, trapezium, trapezoid, capitate, hamate, pisiform)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009702 ; owl:annotatedTarget "Fused wrist bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009703 ; owl:annotatedTarget "Fusion of the 1st metacarpal with another bone. In contrast to the proximal phalanges of the digits 2 to 5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009703 ; owl:annotatedTarget "Fusion involving 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009704 ; owl:annotatedTarget "Chronic cerebrospinal fluid (CSF) lymphocytosis is defined as the finding, in at least two serial CSF examinations, of more than 5 cells per cubic millimeter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009705 ; owl:annotatedTarget "Fusion involving the 2nd long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009706 ; owl:annotatedTarget "Fusion involving the 3rd long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009707 ; owl:annotatedTarget "Fusion involving the 4th long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009708 ; owl:annotatedTarget "Fusion involving the 5th long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009709 ; owl:annotatedTarget "Increased concentration of interferon alpha in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref , "PMID:1832531", "PMID:22025653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009710 ; owl:annotatedTarget "Chilblains, also called perniosis, are an inflammatory skin condition related to an abnormal vascular response to the cold. We are unaware of a reliable estimate of incidence. It typically presents as tender, pruritic red or bluish lesions located symmetrically on the dorsal aspect of the fingers, toes, ears and nose. Less commonly, reports describe involvement of the thighs and buttocks. The lesions present hours after exposure to cold and usually resolve spontaneously in one to three weeks." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009711 ; owl:annotatedTarget "A benign vascular tumor of the retina without any neoplastic characteristics." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009713 ; owl:annotatedTarget "A hemangioblastoma of the spinal cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009714 ; owl:annotatedTarget "An abnormality of the epididymis." . [] oboInOwl:hasDbXref , "PMID:24441657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009715 ; owl:annotatedTarget "A cystadenoma, an epithelial tumor, that originates within the head of the epididymis." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009716 ; owl:annotatedTarget "Small nodular masses which originate in the subependymal region of the lateral ventricles and protrude into the ventricular cavity. They may represent subependymal hamartomas of tuberous sclerosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009717 ; owl:annotatedTarget "Cortical tubers in the brain are hamartomatous lesions typically located at the gray-white matter interface, commonly in the frontal and parietal lobes. Cortical tubers are composed of abnormal glial and neural cells, and the size, number, and location vary among patients." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009718 ; owl:annotatedTarget "A demarcated, largely intraventricular tumor in the region of the foramen of Monro composed of spindle to large plump or ganglion-like cells with eosinophilic to amphophilic cytoplasm and somewhat pleomorphic nuclei with occasional prominent nucleoli. These tumors are almost always associated with tuberous sclerosis." . [] oboInOwl:hasDbXref , "PMID:10695583" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009719 ; owl:annotatedTarget "Hypomelanotic macules (\"ash leaf spots\") are white or lighter patches of skin that may appear anywhere on the body and are caused by a lack of melanin. White ash leaf-shaped macules are considered to be characteristic of tuberous sclerosis." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009719 ; owl:annotatedTarget "Hypomelanotic macules" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30916 ; owl:annotatedTarget "Beilstein:4132418" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009720 ; owl:annotatedTarget "The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009720 ; owl:annotatedTarget "Sebaceous adenomas" . [] oboInOwl:hasDbXref , "PMID:10695583" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009721 ; owl:annotatedTarget "A plaque representing a connective-tissue nevus. Connective tissue naevi are uncommon skin lesions that occur when the deeper layers of the skin do not develop correctly or the components of these layers occur in the wrong proportion. Shagreen patches are oval-shaped and nevoid, skin-colored or occasionally pigmented, smooth or crinkled. The word shagreen refers to a type of roughened untanned leather." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009722 ; owl:annotatedTarget "The presence of small depressions in the dental enamel." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009722 ; owl:annotatedTarget "Dental enamel pits" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009722 ; owl:annotatedTarget "Pitting of tooth enamel" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009722 ; owl:annotatedTarget "Tooth enamel pits" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30916 ; owl:annotatedTarget "Gmelin:2159365" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009723 ; owl:annotatedTarget "A lesion located beneath a fingernail or toenail." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009724 ; owl:annotatedTarget "The presence of fibromata beneath finger or toenails." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009725 ; owl:annotatedTarget "The presence of a neoplasm of the urinary bladder." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009725 ; owl:annotatedTarget "Bladder tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009726 ; owl:annotatedTarget "The presence of a neoplasm of the kidney." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30916 ; owl:annotatedTarget "Reaxys:4132418" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009726 ; owl:annotatedTarget "Kidney cancer" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009726 ; owl:annotatedTarget "Renal tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009726 ; owl:annotatedTarget "Renal tumours" . [] oboInOwl:hasDbXref , "PMID:11264130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009727 ; owl:annotatedTarget "Areas of the retina lacking pigmentation. Punched out areas of chorioretinal hypopigmentation less than 1 disc diameter in size and tending to be located in the midperiphery of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009728 ; owl:annotatedTarget "A benign or malignant neoplasm (tumor) originating in striated muscle, either skeletal muscle or cardiac muscle." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009728 ; owl:annotatedTarget "Tumours of striated muscle" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30916 ; owl:annotatedTarget "4-carboxy-2-oxobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009729 ; owl:annotatedTarget "A benign tumor of cardiac striated muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009730 ; owl:annotatedTarget "A benign tumor of striated muscle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30916 ; owl:annotatedTarget "2-ketoglutarate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009731 ; owl:annotatedTarget "The presence of a hamartoma of the cerebrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009732 ; owl:annotatedTarget "A neurofibroma in which Schwann cells proliferate inside the nerve sheath, producing an irregularly thickened, distorted, tortuous structure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009733 ; owl:annotatedTarget "The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009734 ; owl:annotatedTarget "A glioma originating in the optic nerve or optic chiasm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009735 ; owl:annotatedTarget "A neurofibroma (benign peripheral nerve sheath tumor) localized in the spine." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009735 ; owl:annotatedTarget "Spinal neurofibromas" . [] oboInOwl:hasDbXref , "PMID:30996736" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009736 ; owl:annotatedTarget "Pseudarthrosis, or \"false joint\" of the tibia is the result of a developmental failure in the tibia progressing to spontaneous fracture and subsequent fibrous nonunion. The fracture is rarely present at birth but commonly develops during the first 18 months of life." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009737 ; owl:annotatedTarget "The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris.." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009738 ; owl:annotatedTarget "An abnormality of the antihelix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009739 ; owl:annotatedTarget "Developmental hypoplasia of the antihelix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009740 ; owl:annotatedTarget "Absence of the parotid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009740 ; owl:annotatedTarget "Abnormally small parotid gland" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30920 ; owl:annotatedTarget "4-carboxy-3-hydroxy-3-methylbutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009740 ; owl:annotatedTarget "Underdevelopment of parotid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009740 ; owl:annotatedTarget "Hypoplasia of parotid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009741 ; owl:annotatedTarget "Nephrosclerosis refers to thickening or scarring (\"sclerosis\") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009741 ; owl:annotatedTarget "Scarring of kidney arteries" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009741 ; owl:annotatedTarget "Thickening of kidney artiries" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009742 ; owl:annotatedTarget "Shoulder joint stiffness is a perceived sensation of tightness in shoulders when attempting to move them after a period of inactivity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009742 ; owl:annotatedTarget "Stiff shoulders" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009743 ; owl:annotatedTarget "Double rows of eyelashes." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30921 ; owl:annotatedTarget "Beilstein:3904695" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009744 ; owl:annotatedTarget "An abnormality of the spinal dura mater, which is the outermost of the three layers of the meninges surrounding the spinal cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009745 ; owl:annotatedTarget "Presence of arachnoid cysts of the spinal canal extradurally in the epidural space." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30921 ; owl:annotatedTarget "Gmelin:240388" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Abnormally increased thickness of the nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Broad nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Broad septum of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Thick nasal septum" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_30921 ; owl:annotatedTarget "Reaxys:3904695" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Thick septum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Wide nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009746 ; owl:annotatedTarget "Wide septum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009747 ; owl:annotatedTarget "Abnormally increased hair growth in the lumbosacral region." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_30921 ; owl:annotatedTarget "pentanedioate" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Increased volume of the earlobe, that is, abnormally prominent ear lobules." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Fleshy earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Fleshy earlobes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Large earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Prominent ear lobes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009748 ; owl:annotatedTarget "Prominent ear lobules" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_30921 ; owl:annotatedTarget "glutarate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009751 ; owl:annotatedTarget "Absence of the pectoralis major muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009751 ; owl:annotatedTarget "Absent pectoralis major muscle" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "Bile acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009752 ; owl:annotatedTarget "A bony defect in the skull base." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009752 ; owl:annotatedTarget "Cleft in cranial base" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009752 ; owl:annotatedTarget "Cleft in skull base" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "5beta-bile acid" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009754 ; owl:annotatedTarget "Complete or nearly complete soft tissue fusion of the alveolar ridges." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009754 ; owl:annotatedTarget "Alveolar synechiae" . [] oboInOwl:hasDbXref "PMID:18125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009755 ; owl:annotatedTarget "Partial fusion of the upper and lower eyelid margins by single or multiple bands of tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009755 ; owl:annotatedTarget "Adhesion of eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009755 ; owl:annotatedTarget "Eyelids stuck together" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "5beta-bile acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009756 ; owl:annotatedTarget "A pterygium (or pterygia) occurring in the popliteal region (the back of the knee)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009757 ; owl:annotatedTarget "A pterygium (or pterygia) in the intercrural (groin) region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009758 ; owl:annotatedTarget "Pyramidal skinfold extending from the base to the top of the nails is a rare and distinctive anomaly seen in popliteal pterygia syndrome." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "Bile salt" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009759 ; owl:annotatedTarget "Pterygia affecting the neck." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009759 ; owl:annotatedTarget "Neck pterygium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009760 ; owl:annotatedTarget "Pterygium affecting the elbow. This is a cutaneous web that can lead to severe flexion contracture of the elbow joint. Antecubital pterygium can be unilateral, bilateral, symmetric, or asysmmetric." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009761 ; owl:annotatedTarget "Anterior schisis (cleft or cleavage) of vertebral bodies." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "Gallensaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009762 ; owl:annotatedTarget "Excessive wrinkling of the skin of the face." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009762 ; owl:annotatedTarget "Facial wrinkling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009763 ; owl:annotatedTarget "Chronic pain in the limbs with no clear focal etiology." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009763 ; owl:annotatedTarget "Limb pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009763 ; owl:annotatedTarget "Pain in extremities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "Gallensaeuren" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009765 ; owl:annotatedTarget "Columella extending inferior to the level of the nasal base, when viewed from the side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009765 ; owl:annotatedTarget "Rounded columella" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3098 ; owl:annotatedTarget "bile acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009767 ; owl:annotatedTarget "Small or missing phalangeal bones of the fingers of the hand." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009768 ; owl:annotatedTarget "Increased width of the phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009768 ; owl:annotatedTarget "Wide hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009769 ; owl:annotatedTarget "The presence of short and wide phalanges which taper distally (\"bullet shaped\")." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009769 ; owl:annotatedTarget "Bullet-shaped hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009770 ; owl:annotatedTarget "Curved hand bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "Beilstein:3903735" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "CAS:10023-74-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009771 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009771 ; owl:annotatedTarget "Breakdown of small bones of fingers" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "Gmelin:325619" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009772 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of one or more of the phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009772 ; owl:annotatedTarget "Uneven increase in bone density in finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "PMID:17314444" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009773 ; owl:annotatedTarget "Fusion of two or more phalangeal bones of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009773 ; owl:annotatedTarget "Fused finger bones of the hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "PMID:18783570" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009774 ; owl:annotatedTarget "Triangular shaped hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009775 ; owl:annotatedTarget "Annular constrictions around the digits, limbs, or trunk, occurring congenitally (sometimes causing intrauterine autoamputation) and also associated with a wide variety of disorders. Constrictive amniotic bands are the result of primary amniotic rupture, which can lead to entanglement of fetal tissue (especially limbs) in fibrous amniotic strands." . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009776 ; owl:annotatedTarget "The absence of all phalanges of all the digits of a limb and the associated soft tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009776 ; owl:annotatedTarget "Absent fingers or toes" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "Reaxys:3903735" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009777 ; owl:annotatedTarget "Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009777 ; owl:annotatedTarget "Absent thumb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009777 ; owl:annotatedTarget "Absent thumbs" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "pentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009778 ; owl:annotatedTarget "Hypoplasia (congenital reduction in size) of the thumb." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009778 ; owl:annotatedTarget "Short thumb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009778 ; owl:annotatedTarget "Short thumbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009778 ; owl:annotatedTarget "Small thumbs" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "CH3-[CH2]3-COO(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009779 ; owl:annotatedTarget "Syndactyly with fusion of toes three and four." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "n-propylacetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009779 ; owl:annotatedTarget "Webbed 3rd-4th toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009780 ; owl:annotatedTarget "Horn-like malformations of the iliac crests with symmetrical bilateral central posterior iliac processes. A characteristic finding in the Nail-Patella syndrome. Iliac horns are visible on X-ray and may be palpable, but are asymptomatic." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009781 ; owl:annotatedTarget "A zone of darker pigmentation around the central part of the iris with a roughly cloverleaf or flower shape." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "pentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009782 ; owl:annotatedTarget "Absence or underdevelopment of the biceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009782 ; owl:annotatedTarget "Absent/small biceps" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009782 ; owl:annotatedTarget "Absent/underdeveloped biceps" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_31011 ; owl:annotatedTarget "pentanoic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009783 ; owl:annotatedTarget "Absence of the biceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009783 ; owl:annotatedTarget "Absent biceps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009784 ; owl:annotatedTarget "Absence or underdevelopment of the triceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009784 ; owl:annotatedTarget "Absent/small triceps" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009784 ; owl:annotatedTarget "Absent/underdeveloped triceps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009785 ; owl:annotatedTarget "Absence of the triceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009785 ; owl:annotatedTarget "Absent triceps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009786 ; owl:annotatedTarget "Absence or underdevelopment involving the musculature of the thigh." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009786 ; owl:annotatedTarget "Absent/small thigh muscles" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32439 ; owl:annotatedTarget "Beilstein:3903719" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009786 ; owl:annotatedTarget "Absent/underdeveloped thigh muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009787 ; owl:annotatedTarget "Absence or underdevelopment of the quadriceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009787 ; owl:annotatedTarget "Absent/small quadriceps" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32439 ; owl:annotatedTarget "Gmelin:101040" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009787 ; owl:annotatedTarget "Absent/underdeveloped quadriceps" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009788 ; owl:annotatedTarget "Absence of the quadriceps muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009788 ; owl:annotatedTarget "Absent quads" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32439 ; owl:annotatedTarget "2-aminopropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009789 ; owl:annotatedTarget "The presence of an abscess located around the anus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009790 ; owl:annotatedTarget "A hemisacral defect involving the sacral vertebrae S2 to S5. In hemisacrum, the first sacral vertebra is intact and there is agenesis involving only S2-S5." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009791 ; owl:annotatedTarget "Presence of a bifid sacral bone." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32439 ; owl:annotatedTarget "alaninate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009792 ; owl:annotatedTarget "The presence of a teratoma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009793 ; owl:annotatedTarget "A type of sacrococcygeal teratoma located anterior to the sacrum and entirely inside the body (Altman type IV)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009794 ; owl:annotatedTarget "Congenital developmental defect arising from the primitive branchial apparatus." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32439 ; owl:annotatedTarget "alanine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009794 ; owl:annotatedTarget "Abnormality of branchial apparatus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009794 ; owl:annotatedTarget "Abnormality of branchial arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009795 ; owl:annotatedTarget "A congenital fistula in the neck resulting from incomplete closure of a branchial cleft." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009796 ; owl:annotatedTarget "A branchial cyst is a remnant of embryonic development resulting from a failure of obliteration of a branchial cleft and consists of a subcutaneous cystic mass. Cysts are located anterior or posterior to the ear or in the submandibular region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009797 ; owl:annotatedTarget "Cholesteatoma is a benign but potentially destructive growth consisting of keratinizing epithelium located in the middle ear and/or mastoid process. In cholesteatoma, a skin cyst grows into the middle ear and mastoid. The cyst is not cancerous but can erode tissue and cause destruction of the ear." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009798 ; owl:annotatedTarget "A goiter that is not associated with functional thyroid abnormalities." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009798 ; owl:annotatedTarget "Euthyroid goitre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009799 ; owl:annotatedTarget "The presence of two or more accessory spleens." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009799 ; owl:annotatedTarget "Extra spleen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009800 ; owl:annotatedTarget "Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009800 ; owl:annotatedTarget "Maternal diabetes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009800 ; owl:annotatedTarget "gestational diabetes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009802 ; owl:annotatedTarget "Absence of one or more of the phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009802 ; owl:annotatedTarget "Absent finger bone of the hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32440 ; owl:annotatedTarget "Gmelin:362663" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009803 ; owl:annotatedTarget "Short (hypoplastic) phalanx of finger, affecting one or more phalanges." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009803 ; owl:annotatedTarget "Short finger bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32440 ; owl:annotatedTarget "1-carboxyethanaminium" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget """The absence of one or more teeth from the normal series by a failure to develop""" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Decreased tooth count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Failure of development of some teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Reduced number of teeth" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Teeth, agenesis" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Decreased number of teeth" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32440 ; owl:annotatedTarget "alaninium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Fewer teeth than normal" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009804 ; owl:annotatedTarget "Missing some teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009805 ; owl:annotatedTarget "A form of heart failure characterized by reduced cardiac output. This may be seen in patients with heart failure owing to ischemic heart disease, hypertension, cardiomyopathy, and other causes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009806 ; owl:annotatedTarget "A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP)." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32440 ; owl:annotatedTarget "alanine cation" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009808 ; owl:annotatedTarget "A structural abnormality of a diaphysis of the arm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009808 ; owl:annotatedTarget "Abnormality of shaft of long bone of the upper limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009809 ; owl:annotatedTarget "An anomaly of one or more metaphyses of the arms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009809 ; owl:annotatedTarget "Abnormality of the wide portion of upper limb bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009810 ; owl:annotatedTarget "Abnormality of the joints of the upper limbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009810 ; owl:annotatedTarget "Abnormality of upper limb joint" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "Beilstein:4128885" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009811 ; owl:annotatedTarget "An anomaly of the joint that connects the upper and the lower arm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009811 ; owl:annotatedTarget "Abnormality of the elbow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009811 ; owl:annotatedTarget "Abnormality of the elbows" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "Gmelin:363235" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009812 ; owl:annotatedTarget "Amelia of one or both upper limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009813 ; owl:annotatedTarget "Missing or malformed long bones of the upper limbs with the distal parts (the hands) connected to the variably shortened or even absent upper extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the whole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia)." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "Reaxys:4128885" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009814 ; owl:annotatedTarget "Peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "cysteinate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009815 ; owl:annotatedTarget "Absence (due to failure to form) or underdevelopment of the extremities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009815 ; owl:annotatedTarget "Absent/small extremities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009815 ; owl:annotatedTarget "Absent/underdeveloped extremities" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "hydrogen cysteinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009816 ; owl:annotatedTarget "Leg shortening because of underdevelopment of one or more bones of the lower extremity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009816 ; owl:annotatedTarget "Lower limb undergrowth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009816 ; owl:annotatedTarget "Underdeveloped lower limb bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "2-amino-3-mercaptopropanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009817 ; owl:annotatedTarget "Absent bones of the lower limbs" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "2-amino-3-sulfanylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009818 ; owl:annotatedTarget "Amelia of one or both legs." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "cys(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009819 ; owl:annotatedTarget "Phocomelia affecting only the lower limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009820 ; owl:annotatedTarget "Peromelia affecting only the lower limbs. That is, the distal parts of the leg are missing leading to stump formation." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32456 ; owl:annotatedTarget "cysteine monoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009821 ; owl:annotatedTarget "Forearm shortening because of underdevelopment of one or more bones of the forearm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009821 ; owl:annotatedTarget "Forearm undergrowth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009821 ; owl:annotatedTarget "Short forearm bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009821 ; owl:annotatedTarget "Short forearms" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009821 ; owl:annotatedTarget "Shortened forearm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009822 ; owl:annotatedTarget "Absent forearm bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32457 ; owl:annotatedTarget "Gmelin:49990" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009823 ; owl:annotatedTarget "Absent bones of the upper limbs" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32457 ; owl:annotatedTarget "cysteinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009824 ; owl:annotatedTarget "Arm shortening because of underdevelopment of one or more bones of the upper extremity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009824 ; owl:annotatedTarget "Short arms" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009824 ; owl:annotatedTarget "Shortening of the arms" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009824 ; owl:annotatedTarget "Upper limb undergrowth" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32457 ; owl:annotatedTarget "cysteinate(2-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009825 ; owl:annotatedTarget "Absent bones of the extremities" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32457 ; owl:annotatedTarget "2-amino-3-sulfidopropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009826 ; owl:annotatedTarget "Limb shortening because of underdevelopment of one or more bones of the extremities." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009826 ; owl:annotatedTarget "Limb undergrowth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009826 ; owl:annotatedTarget "Short limb" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009826 ; owl:annotatedTarget "Short limbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009826 ; owl:annotatedTarget "limb shortening" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009827 ; owl:annotatedTarget "Congenital absence (aplasia) of one or more limbs." . [] a owl:Axiom ; rdfs:label "Amelia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0009827 ; owl:annotatedTarget "MEDDRA:10001926" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32457 ; owl:annotatedTarget "cysteine dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009828 ; owl:annotatedTarget "The distal parts of the limbs are missing leading to a stump formation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009829 ; owl:annotatedTarget "Missing or malformed long bones of the extremities with the distal parts (such as hands and/or feet) connected to the variably shortened or even absent extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the hole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia)." . [] a owl:Axiom ; rdfs:label "Phocomelia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0009829 ; owl:annotatedTarget "MEDDRA:10034923" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009830 ; owl:annotatedTarget "Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009830 ; owl:annotatedTarget "Peripheral nerve damage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009830 ; owl:annotatedTarget "Peripheral neuritis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009831 ; owl:annotatedTarget "A focal lesion of a single peripheral nerve. Damage to a sensory nerve is accompanied by sensory impairment of all modalities in the affected anatomic distribution." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009831 ; owl:annotatedTarget "Single damaged nerve" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "Gmelin:325859" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009832 ; owl:annotatedTarget "Any anomaly of distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009832 ; owl:annotatedTarget "Abnormality of the outermost finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "1-carboxy-2-sulfanylethanaminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009833 ; owl:annotatedTarget "An anomaly of middle phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009833 ; owl:annotatedTarget "Abnormality of the middle finger bones of the hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "cysteinium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009834 ; owl:annotatedTarget "Abnormality of the innermost finger bones of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009835 ; owl:annotatedTarget "Absence or underdevelopment of the distal phalanges." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "1-carboxy-2-mercaptoethanaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009835 ; owl:annotatedTarget "Absent/small outermost finger bone of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009835 ; owl:annotatedTarget "Absent/underdeveloped outermost finger bone of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009835 ; owl:annotatedTarget "Small or absent distal phalanges" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "H2cys(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009836 ; owl:annotatedTarget "Abnormally wide (broad) distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009836 ; owl:annotatedTarget "Broad outermost finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009837 ; owl:annotatedTarget "Bullet-shaped outermost finger bone of the hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32458 ; owl:annotatedTarget "cysteine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009838 ; owl:annotatedTarget "Curved outermost finger bone of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009839 ; owl:annotatedTarget "Osteolytic defects of the outermost finger bone of the hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32504 ; owl:annotatedTarget "Gmelin:329083" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32504 ; owl:annotatedTarget "phenylalaninate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009840 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of the distal phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009840 ; owl:annotatedTarget "Uneven increase in bone density in outermost finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32504 ; owl:annotatedTarget "2-amino-3-phenylpropanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009843 ; owl:annotatedTarget "Absent/small middle finger bone of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009843 ; owl:annotatedTarget "Absent/underdeveloped middle finger bone of the hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32504 ; owl:annotatedTarget "phenylalanine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009844 ; owl:annotatedTarget "Increased width of the middle phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009844 ; owl:annotatedTarget "Broad middle finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009845 ; owl:annotatedTarget "Any of the middle phalanges with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009846 ; owl:annotatedTarget "Curved middle finger bonds of the hand" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Beilstein:635782" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32505 ; owl:annotatedTarget "phenylalaninium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32505 ; owl:annotatedTarget "1-carboxy-2-phenylethanaminium" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32505 ; owl:annotatedTarget "phenylalanine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009848 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of one or more of the middle phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009848 ; owl:annotatedTarget "Uneven increase in bone density in the middle finger bones of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009849 ; owl:annotatedTarget "Fusion of a middle phalanx of a finger with another bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009849 ; owl:annotatedTarget "Fused middle finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009850 ; owl:annotatedTarget "Triangular shaped middle finger bones of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009851 ; owl:annotatedTarget "Absent/small innermost finger bones of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009851 ; owl:annotatedTarget "Absent/underdeveloped innermost finger bones of the hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "Gmelin:323509" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009852 ; owl:annotatedTarget "Increased width of the proximal phalanges of the finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009852 ; owl:annotatedTarget "Broad innermost finger bones of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009852 ; owl:annotatedTarget "Wide innermost finger bones of the hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "glycinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009853 ; owl:annotatedTarget "Short and wide proximal phalanges that taper distally . Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009853 ; owl:annotatedTarget "Bullet-shaped innermost finger bones of the hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "H2gly(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009854 ; owl:annotatedTarget "Curved innermost finger bones of the hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "NH3(+)-CH2-COOH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009856 ; owl:annotatedTarget "Uneven increase in bone density of the proximal phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009856 ; owl:annotatedTarget "Uneven increase in bone density in innermost finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009857 ; owl:annotatedTarget "Fused innermost hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009858 ; owl:annotatedTarget "Triangular shaped innermost finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "carboxymethanaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009875 ; owl:annotatedTarget "Triangular shaped outermost bone of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009878 ; owl:annotatedTarget "The presence of cerebellar signs and symptoms such as lack of balance associated with quadrupedal gait (locomotion on all four extremities with a 'bear-like' gait with the legs held straight)." . [] oboInOwl:hasDbXref , , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009879 ; owl:annotatedTarget "An abnormality of the cerebral cortex with fewer gyri but with normal cortical thickness. This pattern is usually often associated with congenital microcephaly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009879 ; owl:annotatedTarget "Cortical gyral simplification" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009880 ; owl:annotatedTarget "Abnormally wide (broad) distal phalanx of finger of all fingers." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "CAS:56-40-6" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32507 ; owl:annotatedTarget "glycine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009880 ; owl:annotatedTarget "Broad outermost hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009881 ; owl:annotatedTarget "Absent distal phalanges of the hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009881 ; owl:annotatedTarget "Absent outermost hand bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009881 ; owl:annotatedTarget "Aplasia of outermost hand bone" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009882 ; owl:annotatedTarget "Short distance from the end of the finger to the most distal interphalangeal crease or the distal interphalangeal joint flexion point. That is, hypoplasia of one or more of the distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009882 ; owl:annotatedTarget "Short outermost finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009883 ; owl:annotatedTarget "This term applies if one or more of the distal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009883 ; owl:annotatedTarget "Duplication of the outermost bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009883 ; owl:annotatedTarget "Notched outermost bone of hand" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "Beilstein:1852023" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009884 ; owl:annotatedTarget "A reduction in diameter of the distal phalanx of finger towards the distal end." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009884 ; owl:annotatedTarget "Tapered outermost finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009886 ; owl:annotatedTarget "Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "Gmelin:81890" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009887 ; owl:annotatedTarget "An abnormality of hair pigmentation (color)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009887 ; owl:annotatedTarget "Abnormality of hair color" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "Reaxys:1852023" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009887 ; owl:annotatedTarget "Abnormality of hair colour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009887 ; owl:annotatedTarget "Abnormality of hair pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009888 ; owl:annotatedTarget "Abnormality of the growth of secondary sexual hair, which normally ensues during puberty. In males, secondary sexual hair usually comprises body hair, including underarm, abdominal, chest, and pubic hair. In females, secondary sexual hair usually comprises a lesser degree of body hair, most prominently underarm and pubic hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009888 ; owl:annotatedTarget "Abnormality of secondary sexual hair" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "UM-BBD_compID:c0559" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009889 ; owl:annotatedTarget "Abnormally increased hair growth with a localized distribution." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009889 ; owl:annotatedTarget "Localised abnormal hair growth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009889 ; owl:annotatedTarget "Localised hirsutism" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "glycinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009889 ; owl:annotatedTarget "Localized abnormal hair growth" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009890 ; owl:annotatedTarget "Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD above the mean. Alternatively, an apparently increased distance between the hairline and the glabella." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009890 ; owl:annotatedTarget "High frontal hairline" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "H2N-CH2-COO(-)" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Flatness of the supraorbital portion of the frontal bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Depressed supraorbital margins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Flat supraorbital margins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Flattened bony protrusion above eyes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Hypoplasia of supraorbital margins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009891 ; owl:annotatedTarget "Underdeveloped brows" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "aminoacetate" . [] oboInOwl:hasDbXref , "PMID:19125421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009892 ; owl:annotatedTarget "Complete absence of any auricular structures." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009892 ; owl:annotatedTarget "Absent ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009892 ; owl:annotatedTarget "Absent ears" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009892 ; owl:annotatedTarget "Congenital absence of external ear" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "CAS:56-40-6" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "gly(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009893 ; owl:annotatedTarget "The presence of telangiectasia of the ear." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32508 ; owl:annotatedTarget "glycine anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009894 ; owl:annotatedTarget "Thickened ears" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009895 ; owl:annotatedTarget "An abnormality of the crus of the helix, which is the horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009896 ; owl:annotatedTarget "An abnormality of the antitragus, which is a small tubercle opposite to the tragus of the ear. The antitragus and the tragus are separated by the intertragic notch." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009897 ; owl:annotatedTarget "An abnormal horizontal axis orientation of the crus of the helix. That is, the main axis of the crus of the helix is perpendicular to the medial longitudinal axis of the ear, instead of sloping inferoposteriorly." . [] oboInOwl:hasSynonymType hp:obsolete_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009897 ; owl:annotatedTarget "Railroad track ears" . [] oboInOwl:hasSynonymType hp:obsolete_synonym ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009897 ; owl:annotatedTarget "Railroad track sign" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "Beilstein:3959092" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009898 ; owl:annotatedTarget "Developmental hypoplasia of the crus of the helix. That is, flatter and/or shorter crus helix than average." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "Gmelin:364417" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009899 ; owl:annotatedTarget "The presence of an abnormally prominent of the crus of the helix. That is, development of the crus helix to the same degree as an average antihelix stem or helix." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "histidinate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009900 ; owl:annotatedTarget "A unilateral absence of sensory perception of sound." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009900 ; owl:annotatedTarget "Deafness in one ear" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009901 ; owl:annotatedTarget "Distortion of the course of the normal folds of the ear and the appearance of supernumerary crura and folds." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009901 ; owl:annotatedTarget "Crumpled ear" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "hydrogen histidinate" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009902 ; owl:annotatedTarget "A notched form of the helix of the ear. That is, a defect in the continuity of the helix, which may occur at any point along its length." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009903 ; owl:annotatedTarget "Presence of nodules in the conjunctiva of the eye." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "2-amino-3-(1H-imidazol-4-yl)propanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009904 ; owl:annotatedTarget "Abnormally prominent ear helix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009905 ; owl:annotatedTarget "Decreased thickness of the helix of the ear." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32529 ; owl:annotatedTarget "histidine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009906 ; owl:annotatedTarget "Absence or underdevelopment of the ear lobes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009906 ; owl:annotatedTarget "Absent/small ear lobes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009906 ; owl:annotatedTarget "Absent/underdeveloped ear lobes" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "CAS:56-40-6" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009907 ; owl:annotatedTarget "Attachment of the lobe to the side of the face at the lowest point of the lobe without curving upward." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009907 ; owl:annotatedTarget "Attached earlobe" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009908 ; owl:annotatedTarget "Sharply demarcated, typically linear and approximately horizontal, indentations in the outer surface of the ear lobe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009908 ; owl:annotatedTarget "Earlobe crease" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "An abnormal orientation of the earlobes such that they point out- and upward. That is, the lateral surface of ear lobe faces superiorly." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "Lobe, uplifted" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "Uplifted earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "Upturned earlobe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "Uplifted earlobes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009909 ; owl:annotatedTarget "Upturned earlobes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32530 ; owl:annotatedTarget "histidinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009910 ; owl:annotatedTarget "Absence of the middle ear ossicles, malleus, incus, and stapes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009910 ; owl:annotatedTarget "Absent middle ear bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32530 ; owl:annotatedTarget "histidinate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009911 ; owl:annotatedTarget "Abnormality of the temporal bone of the skull, which is situated at the sides and base of the skull roughly underlying the region of the face known as the temple." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32530 ; owl:annotatedTarget "2-amino-3-imidazol-1-id-4-ylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009912 ; owl:annotatedTarget "An abnormality of the tragus." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32530 ; owl:annotatedTarget "histidine dianion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009913 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the tragus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009913 ; owl:annotatedTarget "Absent/small tragus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009913 ; owl:annotatedTarget "Absent/underdeveloped tragus" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009914 ; owl:annotatedTarget "Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009914 ; owl:annotatedTarget "Cyclops eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009914 ; owl:annotatedTarget "Single central eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009915 ; owl:annotatedTarget "The presence of a size difference between the left and right cornea." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009915 ; owl:annotatedTarget "Asymmetry of the corneas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009916 ; owl:annotatedTarget "Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009916 ; owl:annotatedTarget "Asymmetric pupil sizes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009916 ; owl:annotatedTarget "Asymmetry of the pupils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009916 ; owl:annotatedTarget "Unequal pupil size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009917 ; owl:annotatedTarget "The presence of remnants of a fetal membrane that persist as strands of tissue crossing the pupil." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009918 ; owl:annotatedTarget "A malposition of the pupil owing to a developmental defect of the iris." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32531 ; owl:annotatedTarget "histidinium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009918 ; owl:annotatedTarget "Displaced pupil" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009919 ; owl:annotatedTarget "A tumor of the eye originating from cells of the retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009919 ; owl:annotatedTarget "Retina tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009919 ; owl:annotatedTarget "Retina tumour" . [] oboInOwl:hasDbXref "PMID:14673306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009920 ; owl:annotatedTarget "A dermal melanocytic hamartoma that presents as bluish hyperpigmentation on the face along the first or second branches of the trigeminal nerve. Nevus of Ota may involve the sclera." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009920 ; owl:annotatedTarget "Naevus fuscoceruleus ophthalmomaxillaris" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009921 ; owl:annotatedTarget "A condition associated with a limitation of the horizontal ocular movement with retraction of the globe and narrowing of the palpebral fissure on adduction" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009921 ; owl:annotatedTarget "Limited eye motility from Duane anomaly" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009921 ; owl:annotatedTarget "Limited eye movement from Duane anomaly" . [] oboInOwl:hasDbXref , "PMID:23772130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009922 ; owl:annotatedTarget "Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32531 ; owl:annotatedTarget "histidinium(1+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009924 ; owl:annotatedTarget "Underdevelopment or absence of the nose or parts thereof." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009924 ; owl:annotatedTarget "Decreased nasal size" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009924 ; owl:annotatedTarget "Decreased size of nose" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32531 ; owl:annotatedTarget "2-ammonio-3-(1H-imidazol-3-ium-4-yl)propanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009924 ; owl:annotatedTarget "Hypoplasia of the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009924 ; owl:annotatedTarget "Hypotrophic nose" . [] oboInOwl:hasDbXref , , "HPO_CONTRIBUTOR:DDD_ncarter", "PMID:28003974" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009926 ; owl:annotatedTarget "Abnormally increased lacrimation, that is, excessive tearing (watering eye)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009926 ; owl:annotatedTarget "Increased tears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009926 ; owl:annotatedTarget "Tearing" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009926 ; owl:annotatedTarget "Watery eyes" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Drug_Central:1319" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32531 ; owl:annotatedTarget "histidine monocation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Complete absence of all nasal structures." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Absent nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Failure of development of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Nasal underdevelopment" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Underdevelopment of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009927 ; owl:annotatedTarget "Missing nose" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009928 ; owl:annotatedTarget "Increase in bulk of the ala nasi." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32532 ; owl:annotatedTarget "Gmelin:1151904" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009929 ; owl:annotatedTarget "A structural abnormality of the columella." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009929 ; owl:annotatedTarget "Anomaly of the columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009929 ; owl:annotatedTarget "Deformity of the columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009929 ; owl:annotatedTarget "Malformation of the columella" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32532 ; owl:annotatedTarget "histidinediium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Asymmetry or size difference between the left and right nostril." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Asymmetry of nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Crooked nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Unequal nostril shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Unequal nostril size" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32532 ; owl:annotatedTarget "histidinium(2+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Uneven nostril shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009930 ; owl:annotatedTarget "Uneven nostril size" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Increased aperture of the nostril." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32532 ; owl:annotatedTarget "4-(2-ammonio-2-carboxyethyl)-1H-imidazol-3-ium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Broad nostril" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Dilated nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Dilated nostril" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Enlarged nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Enlarged nostril" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Increased diameter of nostril" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Wide nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009931 ; owl:annotatedTarget "Wide nostril" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32532 ; owl:annotatedTarget "histidine dication" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009932 ; owl:annotatedTarget "The presence of only a single nostril." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009932 ; owl:annotatedTarget "Mono nostril" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009932 ; owl:annotatedTarget "One nostril" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009932 ; owl:annotatedTarget "Single nare" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009932 ; owl:annotatedTarget "Single nostril" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "Gmelin:815095" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Slender, slit-like aperture of the nostril." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Narrow nares" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Narrow nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Slit-like nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Small nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Thin nostrils" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009933 ; owl:annotatedTarget "Collapsed nostrils" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "lysinate" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009934 ; owl:annotatedTarget "The presence of more than two nostrils." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009934 ; owl:annotatedTarget "Accessory nares" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009934 ; owl:annotatedTarget "Accessory nostril" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009934 ; owl:annotatedTarget "Extra nostril" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009934 ; owl:annotatedTarget "Supernumerary nares" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Gmelin:1808" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "2,6-diaminohexanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009935 ; owl:annotatedTarget "Absence or underdevelopment of the nasal septum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009935 ; owl:annotatedTarget "Ageneis of nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009935 ; owl:annotatedTarget "Underdevelopment of nasal septum" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "lys(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009935 ; owl:annotatedTarget "Failure of development of nasal septum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Abnormally narrow nasal septum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Decreased width of nasal septum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "lysinate(1-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Narrow nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Narrow septum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Thin nasal septum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009936 ; owl:annotatedTarget "Thin septum of nose" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32563 ; owl:annotatedTarget "lysine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009937 ; owl:annotatedTarget "Excess facial hair." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009937 ; owl:annotatedTarget "Excessive face hair" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009938 ; owl:annotatedTarget "Lack or loss of the soft tissues between the zygomata and mandible." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009938 ; owl:annotatedTarget "Depressed cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009938 ; owl:annotatedTarget "Hollow cheeks" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009938 ; owl:annotatedTarget "Sunken cheeks" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Absence of the mandible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Agnathia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Agenesis of the mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Aplasia of the lower jaw bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Failure of development of lower jaw" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32564 ; owl:annotatedTarget "lysinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Failure of development of mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Missing lower jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0009939 ; owl:annotatedTarget "Absence of lower jaw bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32564 ; owl:annotatedTarget "lysinium(1+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Lack of symmetry between the left and right mandible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Tilted mandible" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Asymmetry of lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Canted lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Canted mandible" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Crooked lower jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Lower jaw shifted to one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Tilted lower jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Uneven lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Uneven mandible" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32564 ; owl:annotatedTarget "2,6-diammoniohexanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Deviation of the lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009940 ; owl:annotatedTarget "Deviation of the mandible" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "The presence of an asymmetric mouth." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32564 ; owl:annotatedTarget "lysine monocation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Asymmetry of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Canted mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Crooked mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Tilted mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Uneven mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0009941 ; owl:annotatedTarget "Asymmetry of oral cavity" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:10930630" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009942 ; owl:annotatedTarget "Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009942 ; owl:annotatedTarget "Duplicated thumbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009943 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the thumb. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32565 ; owl:annotatedTarget "lysinediium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009943 ; owl:annotatedTarget "Complete duplication of thumb bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009944 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009944 ; owl:annotatedTarget "Partial duplication of the thumb bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32565 ; owl:annotatedTarget "lysinium(2+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009945 ; owl:annotatedTarget "This term applies if one or more of the phalanges of the 2nd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009945 ; owl:annotatedTarget "Duplication of the bones of index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32565 ; owl:annotatedTarget "1-carboxypentane-1,5-diaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009946 ; owl:annotatedTarget "Extra index finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32565 ; owl:annotatedTarget "lysine dication" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009947 ; owl:annotatedTarget "Partial or complete duplication of the second proximal phalanx of hand." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009948 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of index finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009948 ; owl:annotatedTarget "Partial/complete duplication of the outermost bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009949 ; owl:annotatedTarget "Partial or complete duplication of the middle phalanx of index finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009949 ; owl:annotatedTarget "Partial/complete duplication of the middle bone of the index finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32612 ; owl:annotatedTarget "Gmelin:101585" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009950 ; owl:annotatedTarget "Complete duplication of the distal phalanx of index finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009950 ; owl:annotatedTarget "Complete duplication of the outermost bone of the index finger" . [] oboInOwl:hasDbXref , "PMID:29864040" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009951 ; owl:annotatedTarget "Partial duplication of the distal phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009951 ; owl:annotatedTarget "Notched outermost bone of the index finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009951 ; owl:annotatedTarget "Partial duplication of the outermost bone of the 2nd finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32612 ; owl:annotatedTarget "isoleucinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009952 ; owl:annotatedTarget "Complete duplication of the middle phalanx of index finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009952 ; owl:annotatedTarget "Complete duplication of the middle bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009953 ; owl:annotatedTarget "Partial duplication of the middle phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009953 ; owl:annotatedTarget "Partial duplication of the middle bone of the index finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32612 ; owl:annotatedTarget "ile(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009954 ; owl:annotatedTarget "Complete duplication of the second proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009954 ; owl:annotatedTarget "Complete duplication of the proximal bone of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009955 ; owl:annotatedTarget "Partial duplication of the second proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009955 ; owl:annotatedTarget "Partial duplication of the proximal bones of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009956 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 2nd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32612 ; owl:annotatedTarget "isoleucine anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009956 ; owl:annotatedTarget "Partial duplication of the bones of the index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009957 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the 2nd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009957 ; owl:annotatedTarget "Complete duplication of the bones of the index finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:11019925" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32612 ; owl:annotatedTarget "rel-(2R,3R)-2-amino-3-methylpentanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009958 ; owl:annotatedTarget "Extra middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009959 ; owl:annotatedTarget "This term applies if one or more of the phalanges of the 3rd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009959 ; owl:annotatedTarget "Duplication of middle finger bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32613 ; owl:annotatedTarget "Gmelin:1651827" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009960 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the 3rd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009960 ; owl:annotatedTarget "Complete duplication of middle finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009961 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 3rd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009961 ; owl:annotatedTarget "Partial duplication of middle finger bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32613 ; owl:annotatedTarget "isoleucinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009962 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of middle finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009962 ; owl:annotatedTarget "Partial/complete duplication of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009963 ; owl:annotatedTarget "Partial or complete duplication of the middle phalanx of middle finger." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32613 ; owl:annotatedTarget "H2ile(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009963 ; owl:annotatedTarget "Duplication of the middle bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009964 ; owl:annotatedTarget "Partial or complete duplication of the third proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009964 ; owl:annotatedTarget "Duplication of the proximal bone of the middle finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32613 ; owl:annotatedTarget "isoleucine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009965 ; owl:annotatedTarget "Complete duplication of the distal phalanx of middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009965 ; owl:annotatedTarget "Complete duplication of the outermost bone of the 3rd finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32613 ; owl:annotatedTarget "rel-(1R,2R)-1-carboxy-2-methylbutan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009966 ; owl:annotatedTarget "Complete duplication of the middle phalanx of middle finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009966 ; owl:annotatedTarget "Complete duplication of the middle bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009967 ; owl:annotatedTarget "Complete duplication of the third proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009967 ; owl:annotatedTarget "Complete duplication of the innermost bone of the 3rd finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009968 ; owl:annotatedTarget "Partial duplication of the distal phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009968 ; owl:annotatedTarget "Notched outermost bone of the middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009968 ; owl:annotatedTarget "Partial duplication of the outermost bone of the middle finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009969 ; owl:annotatedTarget "Partial duplication of the middle phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009969 ; owl:annotatedTarget "Partial duplication of the middle bone of the 3rd finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009970 ; owl:annotatedTarget "Partial duplication of the third proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32627 ; owl:annotatedTarget "Reaxys:5245805" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009970 ; owl:annotatedTarget "Partial duplication of the proximal bone of the middle finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32627 ; owl:annotatedTarget "leucinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009971 ; owl:annotatedTarget "Extra ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009972 ; owl:annotatedTarget "This term applies if one or more of the phalanges of the 4th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009972 ; owl:annotatedTarget "Duplication of bones of the ring finger" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:11174716" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32627 ; owl:annotatedTarget "2-amino-4-methylpentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009973 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the 4th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009973 ; owl:annotatedTarget "Complete duplication of the bones of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009974 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 4th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009974 ; owl:annotatedTarget "Partial duplication of the bones of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32627 ; owl:annotatedTarget "leu(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009975 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of ring finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009975 ; owl:annotatedTarget "Partial/complete duplication of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32627 ; owl:annotatedTarget "leucine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009976 ; owl:annotatedTarget "Partial or complete duplication of the middle phalanx of ring finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009976 ; owl:annotatedTarget "Partial/complete duplication of the middle bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009977 ; owl:annotatedTarget "Partial or complete duplication of the fourth proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009977 ; owl:annotatedTarget "Duplication of the proximal bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009978 ; owl:annotatedTarget "Complete duplication of the distal phalanx of ring finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009978 ; owl:annotatedTarget "Complete duplication of the outermost bone of the ring finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32628 ; owl:annotatedTarget "Gmelin:1651836" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009979 ; owl:annotatedTarget "Complete duplication of the middle phalanx of ring finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009979 ; owl:annotatedTarget "Complete duplication of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32628 ; owl:annotatedTarget "leucinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009980 ; owl:annotatedTarget "Complete duplication of the fourth proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009980 ; owl:annotatedTarget "Complete duplication of the proximal bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009981 ; owl:annotatedTarget "Partial duplication of the distal phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009981 ; owl:annotatedTarget "Notched outermost bone of the ring finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009981 ; owl:annotatedTarget "Partial duplication of the outermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009982 ; owl:annotatedTarget "Partial duplication of the middle phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009982 ; owl:annotatedTarget "Partial duplication of the middle bone of the ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32628 ; owl:annotatedTarget "1-carboxy-3-methylbutan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009983 ; owl:annotatedTarget "Partial duplication of the fourth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009983 ; owl:annotatedTarget "Partial duplication of the innermost bone of the ring finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009985 ; owl:annotatedTarget "This term applies if one or more of the phalanges of the 5th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009985 ; owl:annotatedTarget "Partial/complete duplication of little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009985 ; owl:annotatedTarget "Partial/complete duplication of pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009985 ; owl:annotatedTarget "Partial/complete duplication of pinky finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32628 ; owl:annotatedTarget "H2leu(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009986 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the 5th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009986 ; owl:annotatedTarget "Complete duplication of the little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009986 ; owl:annotatedTarget "Complete duplication of the pinkie finger bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32628 ; owl:annotatedTarget "leucine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009986 ; owl:annotatedTarget "Complete duplication of the pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009987 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 5th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009987 ; owl:annotatedTarget "Partial duplication of the little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009987 ; owl:annotatedTarget "Partial duplication of the pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009987 ; owl:annotatedTarget "Partial duplication of the pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009988 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of little finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009988 ; owl:annotatedTarget "Duplication of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009988 ; owl:annotatedTarget "Duplication of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009988 ; owl:annotatedTarget "Duplication of the outermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009989 ; owl:annotatedTarget "Partial or complete duplication of the fifth middle phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009989 ; owl:annotatedTarget "Duplication of the middle little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009989 ; owl:annotatedTarget "Duplication of the middle pinkie finger bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:11542461" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "Beilstein:3937270" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009989 ; owl:annotatedTarget "Duplication of the middle pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009990 ; owl:annotatedTarget "Partial or complete duplication of the fifth proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009990 ; owl:annotatedTarget "Duplication of the innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009990 ; owl:annotatedTarget "Duplication of the innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009990 ; owl:annotatedTarget "Duplication of the innermost pinky finger bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "Gmelin:326565" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009991 ; owl:annotatedTarget "Complete duplication of the distal phalanx of little finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009991 ; owl:annotatedTarget "Complete duplication of the outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009991 ; owl:annotatedTarget "Complete duplication of the outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009991 ; owl:annotatedTarget "Complete duplication of the outermost pinky finger bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "Reaxys:3937270" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009992 ; owl:annotatedTarget "Complete duplication of the fifth middle phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009992 ; owl:annotatedTarget "Complete duplication of the middle little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009992 ; owl:annotatedTarget "Complete duplication of the middle pinkie finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "methioninate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009992 ; owl:annotatedTarget "Complete duplication of the middle pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009993 ; owl:annotatedTarget "Complete duplication of the fifth proximal phalanx of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009993 ; owl:annotatedTarget "Complete duplication of the innermost little finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "2-amino-4-(methylsulfanyl)butanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009993 ; owl:annotatedTarget "Complete duplication of the innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009993 ; owl:annotatedTarget "Complete duplication of the innermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009994 ; owl:annotatedTarget "Partial duplication of the distal phalanx of little finger, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009994 ; owl:annotatedTarget "Notched outermost pinky finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009994 ; owl:annotatedTarget "Partial duplication of outermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009994 ; owl:annotatedTarget "Partial duplication of outermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009994 ; owl:annotatedTarget "Partial duplication of outermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009995 ; owl:annotatedTarget "Partial duplication of the fifth middle phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009995 ; owl:annotatedTarget "Partial duplication of the middle little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009995 ; owl:annotatedTarget "Partial duplication of the middle pinkie finger bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "met(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009995 ; owl:annotatedTarget "Partial duplication of the middle pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009996 ; owl:annotatedTarget "Partial or complete duplication of the fifth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009996 ; owl:annotatedTarget "Partial duplication of the innermost little finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009996 ; owl:annotatedTarget "Partial duplication of the innermost pinkie finger bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009996 ; owl:annotatedTarget "Partial duplication of the innermost pinky finger bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009997 ; owl:annotatedTarget "This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32644 ; owl:annotatedTarget "methionine anion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009997 ; owl:annotatedTarget "Duplication of finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009998 ; owl:annotatedTarget "A complete duplication affecting one or more of the phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009998 ; owl:annotatedTarget "Complete duplication of hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0009999 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0009999 ; owl:annotatedTarget "Partial duplication of hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010000 ; owl:annotatedTarget "A complete duplication affecting one or more of the proximal phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32646 ; owl:annotatedTarget "Gmelin:326567" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010000 ; owl:annotatedTarget "Complete duplication of the innermost bones of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010001 ; owl:annotatedTarget "A complete duplication affecting one or more of the distal phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010001 ; owl:annotatedTarget "Complete duplication of the outermost bones of the hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32646 ; owl:annotatedTarget "methioninium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010002 ; owl:annotatedTarget "A complete duplication affecting one or more of the middle phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a pseudoepiphysis (see corresponding terms) sometimes also referred to as hyperphalangism." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010002 ; owl:annotatedTarget "Complete duplication of the middle bones of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010003 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the proximal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] obo:RO_0002582 true ; a owl:Axiom ; owl:annotatedProperty owl:propertyChainAxiom ; owl:annotatedSource obo:RO_0002177 ; owl:annotatedTarget (obo:RO_0002371 obo:BFO_0000050 ) . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:11806864" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32646 ; owl:annotatedTarget "1-carboxy-3-(methylsulfanyl)propan-1-aminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010003 ; owl:annotatedTarget "Partial duplication of the innermost bones of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010004 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the distal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010004 ; owl:annotatedTarget "Partial duplication of the outermost bone of the hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010005 ; owl:annotatedTarget "A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the middle phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010005 ; owl:annotatedTarget "Partial duplication of the middle bones of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010006 ; owl:annotatedTarget "This term applies if one or more of the proximal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32646 ; owl:annotatedTarget "H2met(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010006 ; owl:annotatedTarget "Duplication of the innermost bones of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010008 ; owl:annotatedTarget "This term applies if one or more of the middle phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010008 ; owl:annotatedTarget "Duplication of the middle bones of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32646 ; owl:annotatedTarget "methionine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010009 ; owl:annotatedTarget "A structural anomaly of the first metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010009 ; owl:annotatedTarget "Abnormality of the 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010010 ; owl:annotatedTarget "Any abnormality of the second metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010010 ; owl:annotatedTarget "Abnormality of the 2nd long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010011 ; owl:annotatedTarget "Any abnormality of the third metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010011 ; owl:annotatedTarget "Abnormality of the 3rd long bone of hand" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "Beilstein:6115348" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010012 ; owl:annotatedTarget "Any abnormality of the fourth metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010012 ; owl:annotatedTarget "Abnormality of the 4th long bone of hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "Gmelin:327371" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010013 ; owl:annotatedTarget "Any abnormality of the fifth metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010013 ; owl:annotatedTarget "Abnormality of the 5th long bone of hand" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "Reaxys:6115348" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010014 ; owl:annotatedTarget "In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits). The epiphysis of the first metacarpal is localized at the proximal end (as seen in the proximal phalanges of the other digits), whereas the epiphyses of the other metacarpal bones are located at the distal end. This term applies if the epiphysis of the 1st metacarpal is in any way abnormal, referring to age and gender depending norms, as seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010014 ; owl:annotatedTarget "Abnormality of the end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "L-asparaginate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010015 ; owl:annotatedTarget "Absent end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "(2S)-2,4-diamino-4-oxobutanoate" . [] oboInOwl:hasDbXref , "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010016 ; owl:annotatedTarget "An epiphysis that curves around from its transverse orientation to a longitudinal one from proximal to distal along one side of the phalanx, thus resembling the letter 'C' and forming a bracket around the diaphysis. This results in a so called delta phalanx characterized by a triangular or trapezoidal shaped bone with a C-shaped epiphyseal plate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010016 ; owl:annotatedTarget "Bracket shaped end part of 1st long bone of hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:12631515" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32650 ; owl:annotatedTarget "L-asparagine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010017 ; owl:annotatedTarget "A cone-shaped appearance of the epiphysis of the 1st metacarpal, producing a 'ball-in-a-socket' appearance." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010017 ; owl:annotatedTarget "Cone-shaped end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010018 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the 1st metacarpal with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010018 ; owl:annotatedTarget "Enlarged end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010019 ; owl:annotatedTarget "Epiphysis of the 1st metacarpal having multiple bony fragments." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010019 ; owl:annotatedTarget "Fragmentation of the end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32651 ; owl:annotatedTarget "L-asparaginium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010020 ; owl:annotatedTarget "Uneven radiographic opacity of the epiphysis of the 1st metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010020 ; owl:annotatedTarget "Irregular end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010021 ; owl:annotatedTarget "The epiphysis of the 1st metacarpal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32651 ; owl:annotatedTarget "(1S)-3-amino-1-carboxy-3-oxopropan-1-aminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010021 ; owl:annotatedTarget "Increased bone density of end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32651 ; owl:annotatedTarget "L-asparagine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010022 ; owl:annotatedTarget "The epiphysis of the first metacarpal is localized at the proximal end of the metacarpal bone although an accessory epiphysis may be located at the distal end of the metacarpal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010023 ; owl:annotatedTarget "Abnormally small size of the epiphysis of the 1st metacarpal with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010023 ; owl:annotatedTarget "Small end part of the 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010024 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the first metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010024 ; owl:annotatedTarget "Speckled calcifications in the end part of the first long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010025 ; owl:annotatedTarget "Triangular end part of the 1st long bone of hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32656 ; owl:annotatedTarget "Gmelin:533547" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010026 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010026 ; owl:annotatedTarget "Absent/small 1st long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010026 ; owl:annotatedTarget "Absent/underdeveloped 1st long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32656 ; owl:annotatedTarget "D-asparaginate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010027 ; owl:annotatedTarget "Increased width of the 1st metacarpal. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010027 ; owl:annotatedTarget "Wide 1st long bone of hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:12754315" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32656 ; owl:annotatedTarget "(2R)-2,4-diamino-4-oxobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010028 ; owl:annotatedTarget "The presence of short and wide 1st metacarpal which tapers distally (\"bullet shaped\")." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010028 ; owl:annotatedTarget "Bullet-shaped 1st long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32656 ; owl:annotatedTarget "D-asparagine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010029 ; owl:annotatedTarget "A deviation from the normal straight shape of the first metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010029 ; owl:annotatedTarget "Curved 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010030 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the 1st metacarpal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32657 ; owl:annotatedTarget "D-asparaginium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010031 ; owl:annotatedTarget "Uneven increase in bone density within the 1st metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010031 ; owl:annotatedTarget "Uneven increase in bone density in 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010033 ; owl:annotatedTarget "This term applies to a triangular shaped 1st metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010033 ; owl:annotatedTarget "Triangular shaped 1st long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32657 ; owl:annotatedTarget "(1R)-3-amino-1-carboxy-3-oxopropan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010034 ; owl:annotatedTarget "A developmental defect characterized by reduced length of the first metacarpal (long bone) of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010034 ; owl:annotatedTarget "Shortened 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0010034 ; owl:annotatedTarget "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32657 ; owl:annotatedTarget "D-asparagine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010035 ; owl:annotatedTarget "Absent first metacarpal (long bone) of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010035 ; owl:annotatedTarget "Absent 1st long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0010035 ; owl:annotatedTarget "In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010036 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the 2nd metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010036 ; owl:annotatedTarget "Absent/small 2nd long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010036 ; owl:annotatedTarget "Absent/underdeveloped 2nd long bone of hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32660 ; owl:annotatedTarget "Gmelin:327370" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010037 ; owl:annotatedTarget "Absence of the second long bone of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010037 ; owl:annotatedTarget "Absent 2nd long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32660 ; owl:annotatedTarget "asparaginate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010038 ; owl:annotatedTarget "Short second metacarpal bone because of developmental hypoplasia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010038 ; owl:annotatedTarget "Shortened 2nd long bone of hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:12770151" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32660 ; owl:annotatedTarget "2,4-diamino-4-oxobutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010039 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the 3rd metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010039 ; owl:annotatedTarget "Absent/small 3rd long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010039 ; owl:annotatedTarget "Absent/underdeveloped 3rd long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32660 ; owl:annotatedTarget "asp(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010040 ; owl:annotatedTarget "Absence of the third long bone of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010040 ; owl:annotatedTarget "Absent 3rd long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010041 ; owl:annotatedTarget "Short third metacarpal bone." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32660 ; owl:annotatedTarget "asparagine anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010041 ; owl:annotatedTarget "Shortened 3rd long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010042 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the 4th metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010042 ; owl:annotatedTarget "Absent/small 4th long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010042 ; owl:annotatedTarget "Absent/underdeveloped 4th long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010043 ; owl:annotatedTarget "Absence of the fourth long bone of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010043 ; owl:annotatedTarget "Absent 4th long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32661 ; owl:annotatedTarget "asparaginium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010044 ; owl:annotatedTarget "Short fourth metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010044 ; owl:annotatedTarget "Shortened 4th long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32661 ; owl:annotatedTarget "3-amino-1-carboxy-3-oxopropan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010045 ; owl:annotatedTarget "Aplasia or Hypoplasia affecting the 5th metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010045 ; owl:annotatedTarget "Absent/small 5th long bone of hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010045 ; owl:annotatedTarget "Absent/underdeveloped 5th long bone of hand" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32661 ; owl:annotatedTarget "H2asp(+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010046 ; owl:annotatedTarget "Absence of the fifth long bone of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010046 ; owl:annotatedTarget "Absent 5th long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32661 ; owl:annotatedTarget "asparagine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010047 ; owl:annotatedTarget "Short fifth metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010047 ; owl:annotatedTarget "Shortened 5th long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010048 ; owl:annotatedTarget "Developmental defect associated with absence of one or more metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010048 ; owl:annotatedTarget "Absent long bone of hand" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32678 ; owl:annotatedTarget "Gmelin:464703" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010049 ; owl:annotatedTarget "Diminished length of one or more metacarpal bones in relation to the others of the same hand or to the contralateral metacarpal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010049 ; owl:annotatedTarget "Shortened long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010049 ; owl:annotatedTarget "Short metacarpal bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:12921899" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32678 ; owl:annotatedTarget "glutaminate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010051 ; owl:annotatedTarget "Displacement of the big toe from its normal position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010051 ; owl:annotatedTarget "Displacement of big toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32678 ; owl:annotatedTarget "2,5-diamino-5-oxopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010052 ; owl:annotatedTarget "An abnormal shape or form of the proximal phalanx of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010052 ; owl:annotatedTarget "Abnormal innermost big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32678 ; owl:annotatedTarget "gln(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010053 ; owl:annotatedTarget "Abnormality of the outermost bone of the big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010054 ; owl:annotatedTarget "An anomaly of the first metatarsal bone." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32678 ; owl:annotatedTarget "glutamine anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010054 ; owl:annotatedTarget "Abnormality of the 1st long bone of foot" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010055 ; owl:annotatedTarget "Visible increase in width of the hallux without an increase in the dorso-ventral dimension." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010055 ; owl:annotatedTarget "Broad big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010055 ; owl:annotatedTarget "Broad halluces" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010055 ; owl:annotatedTarget "Wide big toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32679 ; owl:annotatedTarget "glutaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010056 ; owl:annotatedTarget "Abnormality of the end part of the big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32679 ; owl:annotatedTarget "4-amino-1-carboxy-4-oxobutan-1-aminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010057 ; owl:annotatedTarget "Abnormal big toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010058 ; owl:annotatedTarget "Absent/small big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32679 ; owl:annotatedTarget "H2gln(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010058 ; owl:annotatedTarget "Absent/underdeveloped big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010059 ; owl:annotatedTarget "An increase in width in one or more phalanges of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010059 ; owl:annotatedTarget "Broad bone of big toe" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32679 ; owl:annotatedTarget "glutamine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010059 ; owl:annotatedTarget "Wide bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010060 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010060 ; owl:annotatedTarget "Bullet-shaped bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010061 ; owl:annotatedTarget "A deviation from the normal straight form of one or more phalanges of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010061 ; owl:annotatedTarget "Curve bones of big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:15331688" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "Gmelin:603497" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "argininate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "2-amino-5-(carbamimidamido)pentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010063 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more phalanges of the big toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010063 ; owl:annotatedTarget "Uneven increase in bone density in big toe bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "2-amino-5-guanidinopentanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010064 ; owl:annotatedTarget "Fused big toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "arg(-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010065 ; owl:annotatedTarget "Triangular shaped bones of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010066 ; owl:annotatedTarget "Partial or complete duplication of one or more phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010066 ; owl:annotatedTarget "Duplication of big toe bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010066 ; owl:annotatedTarget "Duplication of great toes" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32695 ; owl:annotatedTarget "arginine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010067 ; owl:annotatedTarget "Absence or underdevelopment of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010067 ; owl:annotatedTarget "Absent/small 1st long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010067 ; owl:annotatedTarget "Absent/underdeveloped 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010068 ; owl:annotatedTarget "Increased side-to-side width of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010068 ; owl:annotatedTarget "Wide 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010069 ; owl:annotatedTarget "An abnormal morphology of the firstmetatarsal bone, which is short and wide and tapers distally, and lacks the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010069 ; owl:annotatedTarget "Bullet-shaped 1st long bone of foot" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "Gmelin:1345599" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010070 ; owl:annotatedTarget "A deviation from the normal straight shape of a proximal phalanx of the 1st metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010070 ; owl:annotatedTarget "Curved 1st long bone of foot" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "argininium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010071 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the first metatarsal." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:15388434" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "argininium(1+)" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "2-ammonio-5-guanidiniopentanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010072 ; owl:annotatedTarget "Uneven increase in bone density of the 1st long bone of foot" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "H2arg(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010073 ; owl:annotatedTarget "Fusion involving the 1st long bone of foot" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "arginine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010074 ; owl:annotatedTarget "Triangular shaped 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010075 ; owl:annotatedTarget "A developmental defect consisting in the duplication of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010075 ; owl:annotatedTarget "Duplicated 1st long bone of foot" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32696 ; owl:annotatedTarget "arginine monocation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010076 ; owl:annotatedTarget "Absent/small outermost big toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010076 ; owl:annotatedTarget "Absent/underdeveloped outermost big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010077 ; owl:annotatedTarget "An increase in width of the distal phalanx of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010077 ; owl:annotatedTarget "Broad outermost bone of big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010077 ; owl:annotatedTarget "Wide outermost bone of big toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32697 ; owl:annotatedTarget "argininediium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010078 ; owl:annotatedTarget "An abnormal morphology of the distal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010078 ; owl:annotatedTarget "Bullet-shaped outermost bone of big toe" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32697 ; owl:annotatedTarget "argininium(2+)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010079 ; owl:annotatedTarget "A deviation from the normal straight form of the distal phalanx of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010079 ; owl:annotatedTarget "Curved outermost bone of big toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32697 ; owl:annotatedTarget "(1-carboxy-4-guanidiniobutyl)ammonium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32697 ; owl:annotatedTarget "H3arg(2+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010081 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:15710237" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32697 ; owl:annotatedTarget "arginine dication" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010082 ; owl:annotatedTarget "Fused outermost bone of big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010083 ; owl:annotatedTarget "Triangular shaped outermost bone of the big toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "Beilstein:4144997" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010084 ; owl:annotatedTarget "Duplication of the outermost bone of big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010085 ; owl:annotatedTarget "Absent/small innermost big toe bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "Gmelin:331342" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010085 ; owl:annotatedTarget "Absent/underdeveloped innermost big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010086 ; owl:annotatedTarget "Increased width of proximal phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010086 ; owl:annotatedTarget "Broad innermost bone of the big toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "Reaxys:4144998" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010087 ; owl:annotatedTarget "An abnormal morphology of the proximal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010087 ; owl:annotatedTarget "Bullet-shaped innermost bone of the big toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "tryptophanate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010088 ; owl:annotatedTarget "A deviation from the normal straight form of the proximal phalanx of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010088 ; owl:annotatedTarget "Curved innermost bone of the big toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "2-amino-3-(1H-indol-3-yl)propanoate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "trp(-)" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32727 ; owl:annotatedTarget "tryptophan anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010090 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010091 ; owl:annotatedTarget "Fused innermost bone of big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16105183" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32728 ; owl:annotatedTarget "tryptophanium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010092 ; owl:annotatedTarget "Triangular shaped innermost bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010093 ; owl:annotatedTarget "Partial or complete duplication of the proximal phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010093 ; owl:annotatedTarget "Duplication of the innermost bone of big toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32728 ; owl:annotatedTarget "1-carboxy-2-(1H-indol-3-yl)ethanaminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010094 ; owl:annotatedTarget "Complete duplication of the proximal phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010094 ; owl:annotatedTarget "Complete duplication of the innermost bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010095 ; owl:annotatedTarget "Partial duplication of the proximal phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010095 ; owl:annotatedTarget "Partial duplication of the innermost bone of big toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32728 ; owl:annotatedTarget "Htrp(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010096 ; owl:annotatedTarget "Complete duplication of the outermost bone of the big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010097 ; owl:annotatedTarget "Notched outermost bone of big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010097 ; owl:annotatedTarget "Partial duplication of the outermost bone of big toe" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32728 ; owl:annotatedTarget "tryptophan cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010098 ; owl:annotatedTarget "A developmental defect consisting in the complete duplication of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010098 ; owl:annotatedTarget "Complete duplication of the 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010099 ; owl:annotatedTarget "A developmental defect consisting in the duplication of part of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010099 ; owl:annotatedTarget "Partial duplication of the 1st long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010100 ; owl:annotatedTarget "Complete duplication of one or more phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010100 ; owl:annotatedTarget "Complete duplication of big toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010101 ; owl:annotatedTarget "Partial duplication of big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010102 ; owl:annotatedTarget "Absent outermost bone of big toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "Beilstein:3548387" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010103 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the distal phalanx of big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010103 ; owl:annotatedTarget "Small outermost bone of big toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "Beilstein:4139515" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010104 ; owl:annotatedTarget "A developmental defect characterized by the absence of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010104 ; owl:annotatedTarget "Absent 1st long bone of foot" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "Gmelin:329372" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010105 ; owl:annotatedTarget "Short first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010105 ; owl:annotatedTarget "Short 1st long bone of foot" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "hydrogen tyrosinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010106 ; owl:annotatedTarget "Absent innermost bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010107 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the proximal phalanx of big toe." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16151895" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "tyrosinate(1-)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010107 ; owl:annotatedTarget "Short innermost big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010109 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010109 ; owl:annotatedTarget "Short big toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "2-amino-3-(4-hydroxyphenyl)propanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010110 ; owl:annotatedTarget "Absent bone of big toe" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32784 ; owl:annotatedTarget "tyrosine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010111 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of a phalanx of big toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010111 ; owl:annotatedTarget "Hypoplastic phalanges of the hallux" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010111 ; owl:annotatedTarget "Short bone of big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010112 ; owl:annotatedTarget "The presence of a supernumerary toe (not a hallux) involving the third or fourth metatarsal with associated osseous syndactyly." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32785 ; owl:annotatedTarget "tyrosinate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010112 ; owl:annotatedTarget "Central polydactyly of feet" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32785 ; owl:annotatedTarget "tyrosinate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010113 ; owl:annotatedTarget "Failure to form (agenesis) of one or more epiphyses of the big toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010113 ; owl:annotatedTarget "Absent end part of big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32785 ; owl:annotatedTarget "2-amino-3-(4-oxidophenyl)propanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010114 ; owl:annotatedTarget "Bracket shaped end part of big toe bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32785 ; owl:annotatedTarget "tyrosine dianion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010115 ; owl:annotatedTarget "Cone-shaped end part of the big toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010116 ; owl:annotatedTarget "Enlarged end part of the big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32786 ; owl:annotatedTarget "tyrosinium" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16214212" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32786 ; owl:annotatedTarget "1-carboxy-2-(4-hydroxyphenyl)ethanaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010117 ; owl:annotatedTarget "Fragmentation of the end part of the big toe bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32786 ; owl:annotatedTarget "tyrosine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010118 ; owl:annotatedTarget "Irregular end part of big toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010119 ; owl:annotatedTarget "Increased bone density of end part of the big toe bone" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32796 ; owl:annotatedTarget "Beilstein:1723806" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010121 ; owl:annotatedTarget "Small end part of the big toe bone" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32796 ; owl:annotatedTarget "Reaxys:1723806" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010122 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010122 ; owl:annotatedTarget "Speckled calcifications in the end part of the big toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32796 ; owl:annotatedTarget "(2R)-2-hydroxypentanedioic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010123 ; owl:annotatedTarget "Triangular end part of the big toe bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32796 ; owl:annotatedTarget "(R)-2-Hydroxyglutarate" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32796 ; owl:annotatedTarget "(R)-Hydroxyglutarate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010124 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the big toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010125 ; owl:annotatedTarget "In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities of the epiphysis of the first metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010125 ; owl:annotatedTarget "Abnormality of the end part of the 1st long bone of foot" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16417482" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010126 ; owl:annotatedTarget "In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities affecting the proximal phalanx of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010126 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the big toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "Beilstein:1723807" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010127 ; owl:annotatedTarget "Failure to form (agenesis) of the epiphysis of the proximal phalanx of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010127 ; owl:annotatedTarget "Absent end part of the innermost bone of the big toe" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "CAS:13095-48-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010128 ; owl:annotatedTarget "The epiphysis of the proximal phalanx of the hallux surrounds the diaphysis, having a bracket-like form." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010128 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of big toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "Gmelin:1218919" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "Reaxys:1723807" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010129 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the big toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "(2S)-2-hydroxypentanedioic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010130 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the big toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32797 ; owl:annotatedTarget "(S)-2-Hydroxyglutarate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010131 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010132 ; owl:annotatedTarget "Irregular end part of the innermost bone of the big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010133 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16444815" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010135 ; owl:annotatedTarget "Small end part of the innermost bone of the big toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Beilstein:506211" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "CAS:127-17-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010136 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010136 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the big toe" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "CAS:127-17-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010137 ; owl:annotatedTarget "Triangular end part of the innermost bone of the big toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Gmelin:101087" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010138 ; owl:annotatedTarget "Failure to form (agenesis) of the epiphysis of the distal phalanx of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010138 ; owl:annotatedTarget "Absent end part of the outermost bone of the big toe" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01060077" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010139 ; owl:annotatedTarget "The epiphysis of the distal phalanx of the hallux surrounds the diaphysis, having a bracket-like form." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010139 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:11762589" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:19260671" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010140 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:22150460" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010141 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:22233273" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010142 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16664855" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010143 ; owl:annotatedTarget "Irregular end part of the outermost bone of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010144 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the big toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Reaxys:506211" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-oxopropanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010146 ; owl:annotatedTarget "Small end part of the outermost bone of the big toe" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "PYRUVIC ACID" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Pyruvic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010147 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the hallux." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010147 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the big toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "pyruvic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010148 ; owl:annotatedTarget "Triangular end part of the outermost bone of the big toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-Oxopropanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010149 ; owl:annotatedTarget "Failure to form (agenesis) of the epiphysis of the 1st metatarsal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010149 ; owl:annotatedTarget "Absent end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-Oxopropansaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010150 ; owl:annotatedTarget "The epiphysis of the 1st metatarsal surrounds the diaphysis, having a bracket-like form." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010150 ; owl:annotatedTarget "Bracket shaped end part of 1st long bone of foot" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-Oxopropionsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010151 ; owl:annotatedTarget "A conical (cone-shaped) appearance of the epiphysis of the first metatarsal of the foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010151 ; owl:annotatedTarget "Cone-shaped end part of the 1st long bone of foot" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16901953" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-ketopropionic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010152 ; owl:annotatedTarget "Enlarged end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "2-oxopropanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010153 ; owl:annotatedTarget "Fragmentation of the end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010154 ; owl:annotatedTarget "Irregular end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Acetylformic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010155 ; owl:annotatedTarget "The epiphysis of the 1st metatarsal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010155 ; owl:annotatedTarget "Increased bone density of end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "BTS" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Brenztraubensaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010157 ; owl:annotatedTarget "Small end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "CH3COCOOH" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010158 ; owl:annotatedTarget "Speckled calcifications in the end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010159 ; owl:annotatedTarget "Triangular end part of the 1st long bone of foot" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "Pyroracemic acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "acetylformic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010160 ; owl:annotatedTarget "Abnormality of the end part of the toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010161 ; owl:annotatedTarget "Abnormality of the long bones of the toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "acide pyruvique" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "alpha-Oxopropionsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010162 ; owl:annotatedTarget "Absence of the epiphyses of the phalanges of the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010162 ; owl:annotatedTarget "Absent end part of the toe bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16918424" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32816 ; owl:annotatedTarget "alpha-ketopropionic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010163 ; owl:annotatedTarget "Bracket shaped end part of the toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010164 ; owl:annotatedTarget "Cone-shaped end part of the toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32832 ; owl:annotatedTarget "threoninate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010165 ; owl:annotatedTarget "Enlarged end part of the toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32832 ; owl:annotatedTarget "rel-(2R,3S)-2-amino-3-hydroxybutanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010166 ; owl:annotatedTarget "Fragmentation of the end part of the toe bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32832 ; owl:annotatedTarget "threonine anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010167 ; owl:annotatedTarget "Irregular end part of the toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32833 ; owl:annotatedTarget "threoninium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010168 ; owl:annotatedTarget "Increased bone density of end part of the toes" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32833 ; owl:annotatedTarget "rel-(1R,2S)-1-carboxy-2-hydroxypropan-1-aminium" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32833 ; owl:annotatedTarget "threonine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010170 ; owl:annotatedTarget "Small end part of the toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010171 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010171 ; owl:annotatedTarget "Speckled calcifications in long toe bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16986325" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010172 ; owl:annotatedTarget "Triangular end part of the toe bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32845 ; owl:annotatedTarget "Gmelin:324692" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010173 ; owl:annotatedTarget "Absent/small toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010173 ; owl:annotatedTarget "Absent/underdeveloped toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32845 ; owl:annotatedTarget "serinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010174 ; owl:annotatedTarget "Increased width of phalanx of one or more toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010174 ; owl:annotatedTarget "Wide toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32845 ; owl:annotatedTarget "2-amino-3-hydroxypropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010175 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010175 ; owl:annotatedTarget "Bullet-shaped phalanges of the toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010175 ; owl:annotatedTarget "Bullet-shaped toe bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32845 ; owl:annotatedTarget "serine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010176 ; owl:annotatedTarget "A deviation from the normal straight form of one or more toe phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010176 ; owl:annotatedTarget "Curved toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010178 ; owl:annotatedTarget "Uneven (irregular) increase in bone density of one or more of the phalanges of the foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010178 ; owl:annotatedTarget "Uneven increase in bone density in toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010179 ; owl:annotatedTarget "Fused toe bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32846 ; owl:annotatedTarget "Gmelin:1925675" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010180 ; owl:annotatedTarget "Triangular shaped toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32846 ; owl:annotatedTarget "serinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010181 ; owl:annotatedTarget "Partial/complete duplication of one or more phalanx of toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010181 ; owl:annotatedTarget "Duplicated toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32846 ; owl:annotatedTarget "1-carboxy-2-hydroxyethanaminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010182 ; owl:annotatedTarget "Abnormality of the outermost bone of the toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:16998855" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32846 ; owl:annotatedTarget "serine cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010183 ; owl:annotatedTarget "Abnormal middle bones of toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010184 ; owl:annotatedTarget "A morphological anomaly of one or more proximal phalanges of one or more toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010184 ; owl:annotatedTarget "Abnormal innermost toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010185 ; owl:annotatedTarget "Absence or underdevelopment of the distal phalanges of the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010185 ; owl:annotatedTarget "Absent/small outermost bones of toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010185 ; owl:annotatedTarget "Absent/underdeveloped outermost bones of toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32859 ; owl:annotatedTarget "Gmelin:49876" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010186 ; owl:annotatedTarget "Increased width of the distal phalanx of toe of one or more toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010186 ; owl:annotatedTarget "Broad outermost bone of the toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010186 ; owl:annotatedTarget "Wide outermost bone of the toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32859 ; owl:annotatedTarget "valinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010187 ; owl:annotatedTarget "An abnormal morphology of one or more distal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010187 ; owl:annotatedTarget "Bullet-shaped outermost bone of the toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32859 ; owl:annotatedTarget "2-amino-3-methylbutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010188 ; owl:annotatedTarget "A deviation from the normal straight form of one or more distal toe phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010188 ; owl:annotatedTarget "Curved outermost bone of the toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32859 ; owl:annotatedTarget "val(-)" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32859 ; owl:annotatedTarget "valine anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010190 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the distal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010190 ; owl:annotatedTarget "Uneven increase in bone density in outermost toe bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32860 ; owl:annotatedTarget "Gmelin:1651060" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010191 ; owl:annotatedTarget "Fused outermost bones of toes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32860 ; owl:annotatedTarget "valinium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010192 ; owl:annotatedTarget "Triangular shaped outermost bone of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010193 ; owl:annotatedTarget "A partial or complete duplication of one or more distal phalanx of toe." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:17154252" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32860 ; owl:annotatedTarget "1-carboxy-2-methylpropan-1-aminium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010193 ; owl:annotatedTarget "Duplication of outermost bone of toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010194 ; owl:annotatedTarget "Absent/small middle bones of toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010194 ; owl:annotatedTarget "Absent/underdeveloped middle bones of toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32860 ; owl:annotatedTarget "H2val(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010195 ; owl:annotatedTarget "Broad middle bones of the toes" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32860 ; owl:annotatedTarget "valine cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010196 ; owl:annotatedTarget "An abnormal morphology of one or more middle phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010196 ; owl:annotatedTarget "Bullet-shaped middle bones of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010197 ; owl:annotatedTarget "A deviation from the normal straight form of one or more middle toe phalanges." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010197 ; owl:annotatedTarget "Curved middle bones of the toes" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "Beilstein:4307988" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010199 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the middle phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010199 ; owl:annotatedTarget "Uneven increase in bone density in middle toe bone" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "Gmelin:82610" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010200 ; owl:annotatedTarget "Fused middle bones of toes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010201 ; owl:annotatedTarget "Triangular shaped middle bones of toes" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "Reaxys:4307988" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010202 ; owl:annotatedTarget "Partial or complete duplication of a middle phalanx of toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010202 ; owl:annotatedTarget "Partial/complete duplication of the middle bones of the toes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "L-prolinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010203 ; owl:annotatedTarget "Absence (agenesis) or underdevelopment of the proximal phalanx of the toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010203 ; owl:annotatedTarget "Absent/small innermost toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010203 ; owl:annotatedTarget "Absent/underdeveloped innermost toe bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:17383967" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "(2S)-pyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010204 ; owl:annotatedTarget "An increase in width of one ore more proximal toe phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010204 ; owl:annotatedTarget "Broad innermost toe bone" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32862 ; owl:annotatedTarget "L-proline anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010205 ; owl:annotatedTarget "An abnormal morphology of one or more of the proximal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010205 ; owl:annotatedTarget "Bullet-shaped innermost toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010206 ; owl:annotatedTarget "A deviation from the normal straight shape of a proximal phalanx of one or more toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010206 ; owl:annotatedTarget "Curved innermost toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010207 ; owl:annotatedTarget "Dissolution or degeneration of bone tissue of the proximal toe phalanx." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32864 ; owl:annotatedTarget "Gmelin:363493" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010208 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the proximal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010208 ; owl:annotatedTarget "Uneven increase in bone density in innermost toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32864 ; owl:annotatedTarget "L-prolinium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010209 ; owl:annotatedTarget "Fused innermost bones of toes" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32864 ; owl:annotatedTarget "(2S)-2-carboxypyrrolidinium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010210 ; owl:annotatedTarget "Triangular shaped innermost toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010211 ; owl:annotatedTarget "Partial/complete duplication of a proximal phalanx of toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010211 ; owl:annotatedTarget "Duplication of innermost toe bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32864 ; owl:annotatedTarget "L-proline cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010212 ; owl:annotatedTarget "One or more bent (flexed) joints of the first (big) toe that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010212 ; owl:annotatedTarget "Joint contracture of the big toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:17582620" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010213 ; owl:annotatedTarget "Chronic loss of joint motion in the tarsometatarsal joint of the hallux due to structural changes in non-bony tissue. The tarsometatarsal joints of the feet are also called Lisfranc's joints." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010214 ; owl:annotatedTarget "The interphalangeal joint of the big toe cannot be straightened actively or passively." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32867 ; owl:annotatedTarget "Gmelin:533350" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010215 ; owl:annotatedTarget "The joint between the first metatarsal and the proximal phalanx of the first (big) toe cannot be straightened actively or passively." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010219 ; owl:annotatedTarget "A foot deformity resulting due to an abnormality affecting the bones of the foot (as well as muscle and soft tissue). In contrast if only the muscle and soft tissue are affected the term positional foot deformity applies." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32867 ; owl:annotatedTarget "D-prolinate" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32867 ; owl:annotatedTarget "(2R)-pyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010220 ; owl:annotatedTarget "Any abnormality of the epiphysis of the second metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010220 ; owl:annotatedTarget "Abnormality of the end part of the 2nd long bone of hand" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32867 ; owl:annotatedTarget "D-proline anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010222 ; owl:annotatedTarget "Any abnormality of the epiphysis of the third metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010222 ; owl:annotatedTarget "Abnormality of the end part of the 3rd long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010223 ; owl:annotatedTarget "The normal epiphysis of the third metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010224 ; owl:annotatedTarget "Any abnormality of the epiphysis of the 4th metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010224 ; owl:annotatedTarget "Abnormality of the end part of the 4th long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010225 ; owl:annotatedTarget "The normal epiphysis of the fourth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010226 ; owl:annotatedTarget "Any abnormality of the epiphysis of the fifth metacarpal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010226 ; owl:annotatedTarget "Abnormality of the end part of the long bone of little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010226 ; owl:annotatedTarget "Abnormality of the end part of the long bone of pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010226 ; owl:annotatedTarget "Abnormality of the end part of the long bone of pinky finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010227 ; owl:annotatedTarget "The normal epiphysis of the fifth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32868 ; owl:annotatedTarget "Gmelin:363492" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010228 ; owl:annotatedTarget "Absence of one or more epiphyses of the phalanges of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010228 ; owl:annotatedTarget "Absent end part of fingers" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:17970719" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32868 ; owl:annotatedTarget "D-prolinium" . [] oboInOwl:hasDbXref , "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010229 ; owl:annotatedTarget "Bracket epiphysis refers to an abnormality in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010229 ; owl:annotatedTarget "Bracket shaped end part of finger bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32868 ; owl:annotatedTarget "(2R)-2-carboxypyrrolidinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010230 ; owl:annotatedTarget "A cone-shaped appearance of the epiphyses of the fingers of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010230 ; owl:annotatedTarget "Cone-shaped end part of finger bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32868 ; owl:annotatedTarget "D-proline cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010231 ; owl:annotatedTarget "Abnormally large size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010231 ; owl:annotatedTarget "Enlarged end part of finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010232 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the phalanges of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010232 ; owl:annotatedTarget "Fragmentation of end part of finger bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "Beilstein:5387795" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010233 ; owl:annotatedTarget "Irregular radiographic opacity of the epiphyses of the phalanges of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010233 ; owl:annotatedTarget "Irregular end part of finger bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "Gmelin:50151" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010234 ; owl:annotatedTarget "Sclerosis of the epiphyses of the phalanges of the fingers, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010234 ; owl:annotatedTarget "Increased bone density of end part of the hand bones" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "Reaxys:5387795" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010235 ; owl:annotatedTarget "A secondary ossification center in the phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010236 ; owl:annotatedTarget "Abnormally small size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "prolinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010236 ; owl:annotatedTarget "Small end part of finger bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010237 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the fingers." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010237 ; owl:annotatedTarget "Speckled calcifications in end part of finger bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "pro(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010238 ; owl:annotatedTarget "A triangular appearance of the epiphyses of the phalanges of the fingers of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010238 ; owl:annotatedTarget "Triangular end part of finger bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "proline anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010239 ; owl:annotatedTarget "Absence of one or more middle phalanx of a finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010239 ; owl:annotatedTarget "Absent middle bones of hand" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18079355" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32871 ; owl:annotatedTarget "pyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010241 ; owl:annotatedTarget "Congenital hypoplasia of one or more proximal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010241 ; owl:annotatedTarget "Short innermost finger bones" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010241 ; owl:annotatedTarget "Short proximal phalanx of finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010242 ; owl:annotatedTarget "Absent innermost bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32872 ; owl:annotatedTarget "prolinium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010243 ; owl:annotatedTarget "Any anomaly of distal epiphysis of phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010243 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32872 ; owl:annotatedTarget "2-carboxypyrrolidinium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32872 ; owl:annotatedTarget "H2pro(+)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010244 ; owl:annotatedTarget "Abnormality of the end part of the middle hand bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32872 ; owl:annotatedTarget "proline cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010245 ; owl:annotatedTarget "Abnormality of the end part of the innermost hand bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32876 ; owl:annotatedTarget "Tertiary amine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010246 ; owl:annotatedTarget "Absent end part of the outermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32876 ; owl:annotatedTarget "tertiary amines" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010247 ; owl:annotatedTarget "An abnormality of the distal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010247 ; owl:annotatedTarget "Bracket shaped end part of the outermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32876 ; owl:annotatedTarget "R3N" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010248 ; owl:annotatedTarget "Cone-shaped end part of the outermost hand bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32876 ; owl:annotatedTarget "tertiaeres Amin" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18396796" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "Primary amine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010249 ; owl:annotatedTarget "Enlarged end part of the outermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "primary amines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010250 ; owl:annotatedTarget "Fragmentation of the end part of the outermost hand bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "Primary monoamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010251 ; owl:annotatedTarget "Irregular end part of the outermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "R-NH2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010252 ; owl:annotatedTarget "Distal epiphyses of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010252 ; owl:annotatedTarget "Increased bone density of end part of the outermost hand bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "RCH2NH2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32877 ; owl:annotatedTarget "primaeres Amin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010254 ; owl:annotatedTarget "Small end part of the outermost hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010255 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost hand bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "Beilstein:1730718" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "CAS:74-98-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010256 ; owl:annotatedTarget "Triangular end part of the outermost hand bones" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "CAS:74-98-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010257 ; owl:annotatedTarget "Absent end part of the middle hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18440992" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "Gmelin:25044" . [] oboInOwl:hasDbXref "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010258 ; owl:annotatedTarget "An abnormality of the middle phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010258 ; owl:annotatedTarget "Bracket shaped end part of the middle hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "propane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010259 ; owl:annotatedTarget "Cone-shaped end part of the middle hand bones" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "propane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010260 ; owl:annotatedTarget "Enlarged end part of the middle hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "CH3-CH2-CH3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "E944" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010261 ; owl:annotatedTarget "Fragmented appearance of the epiphyses of the middle phalanges of the hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010261 ; owl:annotatedTarget "Fragmentation of the end part of the middle hand bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32879 ; owl:annotatedTarget "Propan" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010262 ; owl:annotatedTarget "Irregular end part of middle hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010263 ; owl:annotatedTarget "Epiphyses of the middle phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010263 ; owl:annotatedTarget "Increased bone density of end part of the middle hand bones" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "Beilstein:1740138" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010265 ; owl:annotatedTarget "Small end part of the middle hand bones" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "CAS:593-45-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010266 ; owl:annotatedTarget "Speckled calcifications in the end part of the middle hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18593588" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "CAS:593-45-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010267 ; owl:annotatedTarget "Triangular end part of the middle hand bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "Gmelin:263389" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "PMID:9842728" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010268 ; owl:annotatedTarget "Absent end part of the innermost hand bones" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "Reaxys:1740138" . [] oboInOwl:hasDbXref , "PMID:24432108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010269 ; owl:annotatedTarget "An abnormality of the proximal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010269 ; owl:annotatedTarget "Bracket shaped end part of the innermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "octadecane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010270 ; owl:annotatedTarget "Cone-shaped end part of the innermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "CH3-[CH2]16-CH3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010271 ; owl:annotatedTarget "Enlarged end part of the innermost hand bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "Oktadekan" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32926 ; owl:annotatedTarget "n-octadecane" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010272 ; owl:annotatedTarget "Fragmentation of the end part of the innermost hand bones" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32952 ; owl:annotatedTarget "Amine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010273 ; owl:annotatedTarget "Irregular end part of the innermost hand bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32952 ; owl:annotatedTarget "amines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010274 ; owl:annotatedTarget "Epiphyses of the proximal phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010274 ; owl:annotatedTarget "Increased bone density of end part of the innermost hand bones" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18816054" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32952 ; owl:annotatedTarget "Amin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010275 ; owl:annotatedTarget "A secondary ossification center in the proximal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32952 ; owl:annotatedTarget "Substituted amine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010276 ; owl:annotatedTarget "Small end part of the innermost hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010277 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost hand bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010278 ; owl:annotatedTarget "Triangular end part of the innermost hand bones" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32964 ; owl:annotatedTarget "Gmelin:1242186" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32964 ; owl:annotatedTarget "2,5-diaminopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010280 ; owl:annotatedTarget "Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010280 ; owl:annotatedTarget "Inflammation of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010280 ; owl:annotatedTarget "Gingivostomatitis" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32964 ; owl:annotatedTarget "ornithinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010281 ; owl:annotatedTarget "A gap in the lower lip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010281 ; owl:annotatedTarget "Cleft lower lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010281 ; owl:annotatedTarget "Cleft of the lower lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010281 ; owl:annotatedTarget "Lower labial cleft" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_32964 ; owl:annotatedTarget "ornithine anion" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Height of the vermilion of the medial part of the lower lip more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the lower lip in the frontal view (subjective)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Decreased height of lower lip vermilion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Decreased volume of lower lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Decreased volume of lower lip vermilion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Thin lower lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Thin vermilion border of lower lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010282 ; owl:annotatedTarget "Thin red part of the lower lip" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Increased pigmentation, either focal or generalized, of the mucosa of the mouth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Hyperpigmentation of oral mucosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Oral mucosa melanin pigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Oral racial pigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Dark color of gums" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Dark colour of gums" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Gingival hyperpigmentation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Gingival melanin pigmentation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010284 ; owl:annotatedTarget "Pigmented gums" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010285 ; owl:annotatedTarget "Fibrous band between the mucosal surfaces of the upper and lower alveolar ridges." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010286 ; owl:annotatedTarget "Any abnormality of the salivary glands, the exocrine glands that produce saliva." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010286 ; owl:annotatedTarget "Abnormality of the salivary glands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010286 ; owl:annotatedTarget "Salivary gland disease" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:18840508" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010287 ; owl:annotatedTarget "Any abnormality of the submandibular glands, which are the salivary glands that are located beneath the floor of the mouth, superior to the digastric muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010287 ; owl:annotatedTarget "Abnormality of the submaxillary glands" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32970 ; owl:annotatedTarget "Beilstein:3588289" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010288 ; owl:annotatedTarget "Any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_32970 ; owl:annotatedTarget "Reaxys:3588289" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:mengelstad" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "A gap (cleft) affecting one of the alveolar ridges, which are the protuberances in the mouth that contain the sockets (alveoli) of the teeth. An alveolar cleft can affect all structures of the alveolar ridge, including the gingiva, other mucosa, periosteum, alveolar bone, and teeth. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Cleft anterior maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Cleft of gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Notch of alveolar ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Notch of gum ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Cleft of alveolar process" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010289 ; owl:annotatedTarget "Notch of alveolar process" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32970 ; owl:annotatedTarget "2-aminoethanesulfonate" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010290 ; owl:annotatedTarget "Distance between the labial point of the incisive papilla to the midline junction of the hard and soft palate more than 2 SD below the mean (objective) or apparently decreased length of the hard palate (subjective)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010290 ; owl:annotatedTarget "Decreased length of hard palate" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010291 ; owl:annotatedTarget "Increased size and/or number of soft tissue folds on the palatal side of the maxillary alveolar ridge." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32988 ; owl:annotatedTarget "Amide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010291 ; owl:annotatedTarget "Large lateral palatal folds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010291 ; owl:annotatedTarget "Large lateral palatal ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010291 ; owl:annotatedTarget "Prominent lateral palatal folds" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_32988 ; owl:annotatedTarget "amides" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010292 ; owl:annotatedTarget "Lack of the uvula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010292 ; owl:annotatedTarget "Absent palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010292 ; owl:annotatedTarget "Missing uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010292 ; owl:annotatedTarget "Agenesis of uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010293 ; owl:annotatedTarget "Underdevelopment or absence of the uvula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010293 ; owl:annotatedTarget "Aplasia/hypoplasia of palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010294 ; owl:annotatedTarget "A fistula which connects the oral cavity and the pharyngeal area via the aspects of the soft palate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010294 ; owl:annotatedTarget "Hole in roof of mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010294 ; owl:annotatedTarget "Palatal hole" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010294 ; owl:annotatedTarget "Palatal perforation" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33017 ; owl:annotatedTarget "Gmelin:185086" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010295 ; owl:annotatedTarget "Absence or underdevelopment of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010295 ; owl:annotatedTarget "Lingual aplasia/hypoplasia" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010296 ; owl:annotatedTarget "Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010296 ; owl:annotatedTarget "Tongue tied" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33017 ; owl:annotatedTarget "trihydrogen diphosphate" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Tongue with a median apical indentation or fork." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Bifurcated tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Cleft tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Forked tongue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19028609" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33017 ; owl:annotatedTarget "H3P2O7(-)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Split tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010297 ; owl:annotatedTarget "Snake tongue" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Glossy appearance of the entire tongue surface." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Smooth lingual surface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Smooth surface of tongue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Smooth tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Smooth dorsum of tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Atrophy of dorsum of tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Atrophy of lingual surface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010298 ; owl:annotatedTarget "Atrophy of tongue surface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010299 ; owl:annotatedTarget "Any abnormality of dentin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010299 ; owl:annotatedTarget "Abnormal dentin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010299 ; owl:annotatedTarget "Abnormality of dentin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010299 ; owl:annotatedTarget "Abnormality of dentine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010301 ; owl:annotatedTarget "A heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010301 ; owl:annotatedTarget "Incomplete closure of the vertebral arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "A neoplasm affecting the spinal cord." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal cord tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal cord tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Tumor of the spinal cord" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Tumour of the spinal cord" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal tumor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal tumors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010302 ; owl:annotatedTarget "Spinal tumours" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33019 ; owl:annotatedTarget "Beilstein:185088" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010303 ; owl:annotatedTarget "Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010304 ; owl:annotatedTarget "An outpouching of the spinal meninges." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33019 ; owl:annotatedTarget "hydrogen diphosphate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010305 ; owl:annotatedTarget "Absence (aplasia) of the sacrum." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33019 ; owl:annotatedTarget "HP2O7(3-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010306 ; owl:annotatedTarget "Reduced inferior to superior extent of the thorax." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010306 ; owl:annotatedTarget "Shorter than typical length between neck and abdomen" . [] oboInOwl:hasDbXref , "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010307 ; owl:annotatedTarget "Stridor is a high pitched sound resulting from turbulent air flow in the upper airway." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010307 ; owl:annotatedTarget "Noisy breathing" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33019 ; owl:annotatedTarget "diphosphate" . [] oboInOwl:hasDbXref , "PMID:3424262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010308 ; owl:annotatedTarget "The congenital absence of the sternum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010309 ; owl:annotatedTarget "The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "Beilstein:116150" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010309 ; owl:annotatedTarget "Sternal cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010310 ; owl:annotatedTarget "Accumulation of excessive amounts of lymphatic fluid (chyle) in the pleural cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010311 ; owl:annotatedTarget "Absence or underdevelopment of the breasts." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19120667" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "CAS:493-08-3" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010311 ; owl:annotatedTarget "Absent/small breasts" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010311 ; owl:annotatedTarget "Absent/underdeveloped breasts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010312 ; owl:annotatedTarget "The presence of asymmetrical breasts." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "CAS:493-08-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "The presence of hypertrophy of the breast." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Breast enlargement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Breasts enlarged" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "Gmelin:122981" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Gigantomastia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Hypertrophy of the breasts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Large breast" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010313 ; owl:annotatedTarget "Macromastia" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "Reaxys:116150" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010314 ; owl:annotatedTarget "Premature development of the breasts." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010314 ; owl:annotatedTarget "Premature breast development" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "3,4-dihydro-2H-chromene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010315 ; owl:annotatedTarget "Absence or underdevelopment of the diaphragm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010315 ; owl:annotatedTarget "Absent/small diaprhagm" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010315 ; owl:annotatedTarget "Absent/underdeveloped diaprhagm" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010316 ; owl:annotatedTarget "Ebstein's anomaly refers to an abnormally placed and deformed tricuspid valve characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle with a variable degree of malformation and displacement of the anterior leaflet." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "chromane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010317 ; owl:annotatedTarget "Absence of the scapulae." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010317 ; owl:annotatedTarget "Absent shoulder blade" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "3,4-dihydro-2H-1-benzopyran" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010318 ; owl:annotatedTarget "Absence or underdevelopment of the abdominal musculature." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010318 ; owl:annotatedTarget "Absent/small abdominal wall muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010318 ; owl:annotatedTarget "Absent/underdeveloped abdominal wall muscles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "3,4-dihydrobenzo[b]pyran" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010319 ; owl:annotatedTarget "An anomaly of the second toe." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33224 ; owl:annotatedTarget "Chroman" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010320 ; owl:annotatedTarget "An anomaly of the third toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010320 ; owl:annotatedTarget "Abnormality of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitamin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010321 ; owl:annotatedTarget "An anomaly of the fourth toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010321 ; owl:annotatedTarget "Abnormality of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19449910" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitamina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010322 ; owl:annotatedTarget "An anomaly of the little toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010322 ; owl:annotatedTarget "Abnormality of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010322 ; owl:annotatedTarget "Abnormality of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010322 ; owl:annotatedTarget "Abnormality of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitaminas" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010323 ; owl:annotatedTarget "Abnormality of the end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010324 ; owl:annotatedTarget "An anomaly of a phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010324 ; owl:annotatedTarget "Abnormality of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitamines" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010325 ; owl:annotatedTarget "Absent/small 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010325 ; owl:annotatedTarget "Absent/underdeveloped 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitamins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010326 ; owl:annotatedTarget "Displacement of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33229 ; owl:annotatedTarget "vitaminum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010327 ; owl:annotatedTarget "One or more bent (flexed) joints of the second toe that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33233 ; owl:annotatedTarget "elementary particle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33233 ; owl:annotatedTarget "elementary particles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010329 ; owl:annotatedTarget "Abnormality of the end part of the 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010330 ; owl:annotatedTarget "Abnormality of the bones of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010331 ; owl:annotatedTarget "Absent/small 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010331 ; owl:annotatedTarget "Absent/underdeveloped 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19526731" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010332 ; owl:annotatedTarget "Displacement of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:33684201" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010333 ; owl:annotatedTarget "One or more bent (flexed) joints of the third toe that cannot be straightened actively or passively." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:33847203" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:33896432" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010335 ; owl:annotatedTarget "Abnormality of the end part of the 4th toe bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:34277234" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:34278890" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010337 ; owl:annotatedTarget "Absent/small 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010337 ; owl:annotatedTarget "Absent/underdeveloped 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:7898412" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "PMID:7901680" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010339 ; owl:annotatedTarget "One or more bent (flexed) joints of the fourth toe that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "vitamin E" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "vitamin E vitamer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010341 ; owl:annotatedTarget "Abnormality of the end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010341 ; owl:annotatedTarget "Abnormality of the end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010341 ; owl:annotatedTarget "Abnormality of the end part of the pinky toe bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19544666" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "vitamin E vitamers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010342 ; owl:annotatedTarget "Abnormality of the little toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010342 ; owl:annotatedTarget "Abnormality of the pinkie toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010342 ; owl:annotatedTarget "Abnormality of the pinky toe bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "vitamin-E" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010343 ; owl:annotatedTarget "Absent/small little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010343 ; owl:annotatedTarget "Absent/small pinkie toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010343 ; owl:annotatedTarget "Absent/small pinky toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010343 ; owl:annotatedTarget "Absent/underdeveloped pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33234 ; owl:annotatedTarget "vitamins E" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010344 ; owl:annotatedTarget "Displacement of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010344 ; owl:annotatedTarget "Displacement of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010344 ; owl:annotatedTarget "Displacement of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33238 ; owl:annotatedTarget "atomic entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010345 ; owl:annotatedTarget "One or more bent (flexed) joints of the fifth toe that cannot be straightened actively or passively." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33238 ; owl:annotatedTarget "monoatomic entities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010345 ; owl:annotatedTarget "Joint contractures of the 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010347 ; owl:annotatedTarget "Absent/small bones of 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010347 ; owl:annotatedTarget "Absent/underdeveloped bones of 2nd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33240 ; owl:annotatedTarget "coordination entities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010348 ; owl:annotatedTarget "Broad bones of the 2nd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33240 ; owl:annotatedTarget "coordination entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010349 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010349 ; owl:annotatedTarget "Bullet-shaped bones of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33240 ; owl:annotatedTarget "coordination compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010350 ; owl:annotatedTarget "A deviation from the normal straight form of one or more phalanges of the second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010350 ; owl:annotatedTarget "Curved bones of the 2nd toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010350 ; owl:annotatedTarget "Curved phalanges of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33241 ; owl:annotatedTarget "oxoacid derivatives" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19738917" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33242 ; owl:annotatedTarget "inorganic hydrides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010352 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the phalanges of the second toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010352 ; owl:annotatedTarget "Uneven increase in bone density in 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33245 ; owl:annotatedTarget "organic fundamental parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010353 ; owl:annotatedTarget "Fusion of the interphalangeal joints of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010353 ; owl:annotatedTarget "Fused bones of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33245 ; owl:annotatedTarget "organic parent hydrides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010354 ; owl:annotatedTarget "Triangular shaped bone of 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010354 ; owl:annotatedTarget "Triangular shaped bone of second toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010355 ; owl:annotatedTarget "Partial or complete duplication of a phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010355 ; owl:annotatedTarget "Duplication of the bones of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33246 ; owl:annotatedTarget "inorganic groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010356 ; owl:annotatedTarget "Abnormality of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010357 ; owl:annotatedTarget "Abnormality of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33247 ; owl:annotatedTarget "organic groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010358 ; owl:annotatedTarget "Abnormality of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010359 ; owl:annotatedTarget "Absent/small bones of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010359 ; owl:annotatedTarget "Absent/underdeveloped bones of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010360 ; owl:annotatedTarget "Wide bones of 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33248 ; owl:annotatedTarget "hydrocarbyl group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010361 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010361 ; owl:annotatedTarget "Bullet-shaped bones of 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33248 ; owl:annotatedTarget "hydrocarbyl groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010362 ; owl:annotatedTarget "A deviation from the normal straight form of one or more phalanges of the third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010362 ; owl:annotatedTarget "Curved bones of 3rd toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010362 ; owl:annotatedTarget "Curved phalanges of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33248 ; owl:annotatedTarget "groupe hydrocarbyle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19916621" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33248 ; owl:annotatedTarget "grupo hidrocarbilo" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33248 ; owl:annotatedTarget "grupos hidrocarbilo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010364 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the phalanges of the third toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010364 ; owl:annotatedTarget "Uneven increase in bone density in 3rd toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33249 ; owl:annotatedTarget "organyl group" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010365 ; owl:annotatedTarget "Fused bones of 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33249 ; owl:annotatedTarget "organyl groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010366 ; owl:annotatedTarget "Triangular shaped 3rd toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33249 ; owl:annotatedTarget "groupe organyle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010367 ; owl:annotatedTarget "Partial or complete duplication of phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010367 ; owl:annotatedTarget "Duplication of 3rd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010368 ; owl:annotatedTarget "Abnormality of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33249 ; owl:annotatedTarget "grupo organilo" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010369 ; owl:annotatedTarget "Abnormality of the middle bone of 3rd toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33249 ; owl:annotatedTarget "grupos organilo" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010370 ; owl:annotatedTarget "An anomaly of the proximal phalanx of third toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010370 ; owl:annotatedTarget "Abnormality of the innermost bone of 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010371 ; owl:annotatedTarget "Absent/small bones of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010371 ; owl:annotatedTarget "Absent/underdeveloped bones of 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010372 ; owl:annotatedTarget "Broad bones of the 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "atom" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010373 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010373 ; owl:annotatedTarget "Bullet-shaped bones of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:19924257" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "atome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010374 ; owl:annotatedTarget "A deviation from the normal straight form of one or more phalanges of the fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010374 ; owl:annotatedTarget "Curved bones of 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "atomo" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "atoms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010376 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the phalanges of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010376 ; owl:annotatedTarget "Patchy sclerosis of the phalanges of the 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010376 ; owl:annotatedTarget "Uneven increase in bone density in 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "atomus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010377 ; owl:annotatedTarget "Fused bones of 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "element" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010378 ; owl:annotatedTarget "Triangular shaped bones of 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33250 ; owl:annotatedTarget "elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010379 ; owl:annotatedTarget "Partial or complete duplication of phalanx of fourth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010379 ; owl:annotatedTarget "Duplication of 4th toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010380 ; owl:annotatedTarget "Abnormality of the outermost 4th toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "nucleus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010381 ; owl:annotatedTarget "Abnormality of middle 4th toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010382 ; owl:annotatedTarget "Abnormal innermost 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "Atomkern" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010383 ; owl:annotatedTarget "Absent/small little toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010383 ; owl:annotatedTarget "Absent/small pinkie toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010383 ; owl:annotatedTarget "Absent/small pinky toe bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "Kern" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010383 ; owl:annotatedTarget "Absent/underdeveloped pinky toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010384 ; owl:annotatedTarget "Broad bones of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010384 ; owl:annotatedTarget "Broad bones of the pinkie toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:21751272" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "noyau" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010384 ; owl:annotatedTarget "Broad bones of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010385 ; owl:annotatedTarget "An abnormal morphology of one or more phalanges of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010385 ; owl:annotatedTarget "Bullet-shaped bones of the little toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "noyau atomique" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010385 ; owl:annotatedTarget "Bullet-shaped bones of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010385 ; owl:annotatedTarget "Bullet-shaped bones of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010386 ; owl:annotatedTarget "A deviation from the normal straight form of one or more phalanges of the fifth toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "nuclei" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010386 ; owl:annotatedTarget "Curved little toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010386 ; owl:annotatedTarget "Curved pinkie toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010386 ; owl:annotatedTarget "Curved pinky toe bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "nucleo" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "nucleo atomico" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010388 ; owl:annotatedTarget "Patchy (irregular) increase in bone density of one or more of the phalanges of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010388 ; owl:annotatedTarget "Uneven increase in bone density in little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010388 ; owl:annotatedTarget "Uneven increase in bone density in pinkie toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33252 ; owl:annotatedTarget "nucleus atomi" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010388 ; owl:annotatedTarget "Uneven increase in bone density in pinky toe bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33253 ; owl:annotatedTarget "nucleon" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010389 ; owl:annotatedTarget "Fused bones in the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010389 ; owl:annotatedTarget "Fused bones in the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010389 ; owl:annotatedTarget "Fused bones in the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33253 ; owl:annotatedTarget "nucleon" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010390 ; owl:annotatedTarget "Triangular shaped little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010390 ; owl:annotatedTarget "Triangular shaped pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010390 ; owl:annotatedTarget "Triangular shaped pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33253 ; owl:annotatedTarget "Nukleon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010391 ; owl:annotatedTarget "Partial or complete duplication of one or more phalanx of little toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010391 ; owl:annotatedTarget "Duplication of the bones of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010391 ; owl:annotatedTarget "Duplication of the bones of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010391 ; owl:annotatedTarget "Duplication of the bones of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33253 ; owl:annotatedTarget "Nukleonen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010392 ; owl:annotatedTarget "Abnormality of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010392 ; owl:annotatedTarget "Abnormality of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010392 ; owl:annotatedTarget "Abnormality of the outermost bone of the pinky toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22044190" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33253 ; owl:annotatedTarget "nucleons" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010393 ; owl:annotatedTarget "Abnormality of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010393 ; owl:annotatedTarget "Abnormality of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010393 ; owl:annotatedTarget "Abnormality of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33256 ; owl:annotatedTarget "primary amide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010394 ; owl:annotatedTarget "Abnormality of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010394 ; owl:annotatedTarget "Abnormality of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010394 ; owl:annotatedTarget "Abnormality of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33256 ; owl:annotatedTarget "primary amides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010395 ; owl:annotatedTarget "Absence (agenesis) or underdevelopment of the proximal phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010395 ; owl:annotatedTarget "Absent/small innermost 2nd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010395 ; owl:annotatedTarget "Absent/underdeveloped innermost 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33259 ; owl:annotatedTarget "homoatomic entity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010396 ; owl:annotatedTarget "Broad innermost bone of 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010397 ; owl:annotatedTarget "An abnormal morphology of the proximal phalanx of the 2nd toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33259 ; owl:annotatedTarget "homoatomic molecular entities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010397 ; owl:annotatedTarget "Bullet-shaped innermost bone of 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010398 ; owl:annotatedTarget "A deviation from the normal straight form of the proximal phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010398 ; owl:annotatedTarget "Curved innermost bone of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33259 ; owl:annotatedTarget "homoatomic molecular entity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33261 ; owl:annotatedTarget "organosulfur compound" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33261 ; owl:annotatedTarget "organosulfur compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010400 ; owl:annotatedTarget "Uneven increase in bone density in the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33273 ; owl:annotatedTarget "polyatomic anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010401 ; owl:annotatedTarget "Fused innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33280 ; owl:annotatedTarget "chemical messenger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010402 ; owl:annotatedTarget "Triangular shaped innermost 2nd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010403 ; owl:annotatedTarget "Partial or complete duplication of proximal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010403 ; owl:annotatedTarget "Duplication of innermost 2nd toe bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22079563" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:12964249" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010404 ; owl:annotatedTarget "Absent/small middle bone of 2nd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010404 ; owl:annotatedTarget "Absent/underdeveloped middle bone of 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:22117953" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010405 ; owl:annotatedTarget "Broad middle bone of 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:22439833" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010406 ; owl:annotatedTarget "An abnormal morphology of the middle phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010406 ; owl:annotatedTarget "Bullet-shaped middle bone of 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:22849268" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010407 ; owl:annotatedTarget "A deviation from the normal straight form of the middle phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010407 ; owl:annotatedTarget "Curved middle bone of 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:22849276" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "PMID:22958833" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010409 ; owl:annotatedTarget "Uneven increase in bone density in the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "Antibiotika" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010410 ; owl:annotatedTarget "Fused middle bone of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "Antibiotikum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010411 ; owl:annotatedTarget "Triangular shaped middle bone of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antibiotic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010412 ; owl:annotatedTarget "Partial or complete duplication of middle phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010412 ; owl:annotatedTarget "Duplication of middle bone of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antibiotics" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010413 ; owl:annotatedTarget "Absent/small outermost 2nd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010413 ; owl:annotatedTarget "Absent/underdeveloped outermost 2nd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010414 ; owl:annotatedTarget "Broad outermost bone of the 2nd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22234938" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antibiotique" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010414 ; owl:annotatedTarget "Wide outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010415 ; owl:annotatedTarget "An abnormal morphology of the distal phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010415 ; owl:annotatedTarget "Bullet-shaped outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antimicrobial" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010416 ; owl:annotatedTarget "A deviation from the normal straight form of the distal phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010416 ; owl:annotatedTarget "Curved outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antimicrobial agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "antimicrobials" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "microbicide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010418 ; owl:annotatedTarget "Uneven increase in bone density in the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33281 ; owl:annotatedTarget "microbicides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010419 ; owl:annotatedTarget "Fused outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33282 ; owl:annotatedTarget "antibacterial agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010420 ; owl:annotatedTarget "Triangular shaped outermost 2nd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010421 ; owl:annotatedTarget "Partial or complete duplication of the distal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010421 ; owl:annotatedTarget "Duplication of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33282 ; owl:annotatedTarget "antibacterials" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010422 ; owl:annotatedTarget "Complete duplication of proximal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010422 ; owl:annotatedTarget "Complete duplication of the innermost 2nd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010423 ; owl:annotatedTarget "Partial duplication of proximal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010423 ; owl:annotatedTarget "Partial duplication of the innermost 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33282 ; owl:annotatedTarget "bactericide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010424 ; owl:annotatedTarget "Complete duplication of the distal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010424 ; owl:annotatedTarget "Complete duplication of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010425 ; owl:annotatedTarget "Partial duplication of the distal phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010425 ; owl:annotatedTarget "Partial duplication of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33282 ; owl:annotatedTarget "bactericides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010426 ; owl:annotatedTarget "Complete duplication of middle phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010426 ; owl:annotatedTarget "Complete duplication of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010427 ; owl:annotatedTarget "Partial duplication of middle phalanx of second toe." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33284 ; owl:annotatedTarget "nutrients" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010427 ; owl:annotatedTarget "Partial duplication of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010428 ; owl:annotatedTarget "Partial duplication of a phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010428 ; owl:annotatedTarget "Partial duplication of 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33285 ; owl:annotatedTarget "heteroorganic entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010429 ; owl:annotatedTarget "Complete duplication of a phalanx of second toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010429 ; owl:annotatedTarget "Complete duplication of the 2nd toe bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010430 ; owl:annotatedTarget "Absent 2nd toe bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33285 ; owl:annotatedTarget "organoelement compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010431 ; owl:annotatedTarget "Reduced length of one or more phalanx of second toe as a result of developmental hypoplasia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010431 ; owl:annotatedTarget "Short 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33286 ; owl:annotatedTarget "agrichemical" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010432 ; owl:annotatedTarget "Absence of distal phalanx of the second toe as a result of developmental aplasia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010432 ; owl:annotatedTarget "Absent outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33286 ; owl:annotatedTarget "agrichemicals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010433 ; owl:annotatedTarget "Reduced length of the distal phalanx of the second toe as a result of developmental hypoplasia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010433 ; owl:annotatedTarget "Short outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33286 ; owl:annotatedTarget "agricultural chemicals" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010434 ; owl:annotatedTarget "Absent middle bone of 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33286 ; owl:annotatedTarget "agrochemicals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010435 ; owl:annotatedTarget "Reduced length of the middle phalanx of second toe as a result of developmental hypoplasia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010435 ; owl:annotatedTarget "Short middle 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33287 ; owl:annotatedTarget "fertiliser" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010436 ; owl:annotatedTarget "Absent innermost 2nd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010437 ; owl:annotatedTarget "Reduced length of the proximal phalanx of second toe as a result of developmental hypoplasia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33287 ; owl:annotatedTarget "fertilizers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010437 ; owl:annotatedTarget "Short innermost 2nd toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010438 ; owl:annotatedTarget "A structural abnormality of the interventricular septum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010438 ; owl:annotatedTarget "Abnormal interventricular septum morphology" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010440 ; owl:annotatedTarget "In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the fibular side of the foot, next top the little toe), preaxial (on the tibial side of the foot, next to the big toe) or mesoaxial (somewhere central, between big and little toe), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010441 ; owl:annotatedTarget "In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the ulnar side of the hand, next to the little finger), preaxial (on the radial side of the hand, next to the thumb) or mesoaxial (somewhere central, between thumb and little finger), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22293292" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "food material" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010442 ; owl:annotatedTarget "A congenital anomaly characterized by the presence of supernumerary fingers or toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010442 ; owl:annotatedTarget "More than five fingers or toes on hands or feet" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "food materials" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010443 ; owl:annotatedTarget "A bifid or bifurcated appearance of the femur as seen on x-rays, possible appearing as a more or less severe bowing of the upper leg. Might be associated with hip dysplasia on the affected side." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010443 ; owl:annotatedTarget "Notched thighbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010443 ; owl:annotatedTarget "Split thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "food role" . [] oboInOwl:hasDbXref , , "PMID:32491496" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010444 ; owl:annotatedTarget "The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010445 ; owl:annotatedTarget "An ostium primum atrial septal defect is located in the most anterior and inferior aspect of the atrial septum. The ostium primum refers to an anterior and inferior opening (ostium) within the septum primum, which divides the rudimentary atrium during fetal development. The ostium primum is normally sealed by fusion of the superior and inferior endocardial cushions around 5 weeks' gestation. Ostium primum defects result from a failure of the fusion of the embryologic endocardial cushion and septum primum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010445 ; owl:annotatedTarget "Atrial septal defect, primum type" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "foods" . [] oboInOwl:hasDbXref , "PMID:18222317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010446 ; owl:annotatedTarget "A narrowing of the orifice of the tricuspid valve of the heart." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "foodstuff" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010447 ; owl:annotatedTarget "An abnormal connection between the epithelialised surface of the anal canal and the perianal skin." . [] a owl:Axiom ; rdfs:label "Anal fistula" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0010447 ; owl:annotatedTarget "MEDDRA:10002156" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33290 ; owl:annotatedTarget "foodstuffs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010448 ; owl:annotatedTarget "A developmental defect resulting in complete obliteration of the lumen of the colon. That is, there is an abnormal closure, or atresia of the tubular structure of the colon." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33295 ; owl:annotatedTarget "diagnostic aid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010450 ; owl:annotatedTarget "An abnormal narrowing of the lumen of the esophagus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010450 ; owl:annotatedTarget "Narrowing of the esophagus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010450 ; owl:annotatedTarget "Narrowing of the oesophagus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010451 ; owl:annotatedTarget "Absence or underdevelopment of the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010451 ; owl:annotatedTarget "Absent/small spleen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010451 ; owl:annotatedTarget "Absent/underdeveloped spleen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33296 ; owl:annotatedTarget "alkali metal molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010452 ; owl:annotatedTarget "An abnormal (non-anatomic) location of the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010452 ; owl:annotatedTarget "Abnormal spleen location" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "pnictogens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010453 ; owl:annotatedTarget "Pelvic asymmetry refers to asymmetric positioning of landmarks on the two sides of the pelvis and may have a structural or functional etiology." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010453 ; owl:annotatedTarget "Pelvic asymmetry" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010454 ; owl:annotatedTarget "The presence of osteophytes (bone spurs), i.e., of bony projections originating from the acetabulum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010455 ; owl:annotatedTarget "An exaggeration of the normal arched form of the acetabular roof such that it takes on a steep appearance." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22401276" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "group 15 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010456 ; owl:annotatedTarget "An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010458 ; owl:annotatedTarget "Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In female pseudohermaphroditism, the genotype is female (XX) and the gonads are ovaries, but the external genitalia are virilized." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "group V elements" . [] oboInOwl:hasDbXref , "PMID:11327376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010459 ; owl:annotatedTarget "The presence of both ovarian and testicular tissues either in the same or in opposite gonads. Affected persons have ambiguous genitalia and may have 46,XX or 46,XY karyotypes or 46,XX/XY mosaicism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010460 ; owl:annotatedTarget "Abnormality of the female genital system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "nitrogenoideos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010461 ; owl:annotatedTarget "Abnormality of the male genital system." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010461 ; owl:annotatedTarget "Abnormal male genitals" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010461 ; owl:annotatedTarget "Abnormality of the male genitalia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "nitrogenoides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010462 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the ovary." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010462 ; owl:annotatedTarget "Absent/small ovary" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010462 ; owl:annotatedTarget "Absent/underdeveloped ovary" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "pnictogene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010463 ; owl:annotatedTarget "Aplasia, that is failure to develop, of the ovary." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010463 ; owl:annotatedTarget "Absent ovary" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010463 ; owl:annotatedTarget "Bilateral absent ovaries" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010464 ; owl:annotatedTarget "A developmental disorder characterized by the progressive loss of primordial germ cells in the developing ovaries of an embryo, leading to hypoplastic ovaries composed of wavy connective tissue with occasional clumps of granulosa cells, and frequently mesonephric or hilar cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33300 ; owl:annotatedTarget "pnictogenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010465 ; owl:annotatedTarget "The onset of puberty before the age of 8 years in girls." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010468 ; owl:annotatedTarget "Absence or underdevelopment of the testes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010468 ; owl:annotatedTarget "Absent/small testes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010468 ; owl:annotatedTarget "Absent/underdeveloped testes" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010469 ; owl:annotatedTarget "Testis not palpable in the scrotum or inguinal canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010469 ; owl:annotatedTarget "Absence of palpable testicules" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33302 ; owl:annotatedTarget "pnictogen molecular entity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010469 ; owl:annotatedTarget "Absent testes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010470 ; owl:annotatedTarget "The presence of more than two testes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010470 ; owl:annotatedTarget "Extra testes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33302 ; owl:annotatedTarget "pnictogen molecular entities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "PMID:17084588" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010471 ; owl:annotatedTarget "Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "PMID:22434786" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "chalcogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010472 ; owl:annotatedTarget "An abnormality in the synthesis or catabolism of heme. Heme is composed of ferrous iron and protoporphyrin IX and is an essential molecule as the prosthetic group of hemeproteins such as hemoglobin, myoglobin, mitochondrial and microsomal cytochromes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "chalcogens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010473 ; owl:annotatedTarget "Abnormally increased excretion of porphyrins in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010474 ; owl:annotatedTarget "Buildups of minerals that form in the urinary bladder." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010475 ; owl:annotatedTarget "Cloacal exstrophy is a severe anterior abdominal wall defect in which the two hemibladders are visible and are separated by a midline intestinal plate, an omphalocele, and an imperforate anus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "Chalkogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010476 ; owl:annotatedTarget "Absence or underdevelopment of the urinary bladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010476 ; owl:annotatedTarget "Absent/small bladder" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010476 ; owl:annotatedTarget "Absent/underdeveloped bladder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "Chalkogene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010477 ; owl:annotatedTarget "Aplasia (absence) of the urinary bladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010477 ; owl:annotatedTarget "Absent bladder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "anfigeno" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010478 ; owl:annotatedTarget "Abnormality of the urachus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "anfigenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010479 ; owl:annotatedTarget "Persistence of the urachal canal resulting in a canal between the bladder and the umbilicus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "calcogeno" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010480 ; owl:annotatedTarget "The presence of an abnormal connection between the urethra and another organ or the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010481 ; owl:annotatedTarget "The presence of an abnormal membrane obstructing the urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010482 ; owl:annotatedTarget "Shortening of the arms predominantly affecting terminal parts of the arm in relation to the upper and middle limb segments." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010483 ; owl:annotatedTarget "Amniotic constriction rings affecting the arms." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "calcogenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010484 ; owl:annotatedTarget "Abnormal increase in size of the upper limbs (due to an increase of the size of cells)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010484 ; owl:annotatedTarget "Increased size of upper limb" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010485 ; owl:annotatedTarget "The ability of the elbow joint to move beyond its normal range of motion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "chalcogene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010486 ; owl:annotatedTarget "An abnormality of the hypothenar eminence, i.e., of the muscles on the ulnar side of the palm of the hand (i.e., on the side of the little finger)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "chalcogenes" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010487 ; owl:annotatedTarget "Reduced muscle mass on the ulnar side of the palm, that is, reduction in size of the hypothenar eminence." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Reaxys:635782" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "group 16 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010488 ; owl:annotatedTarget "Absence or underdevelopment of the palmar creases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010488 ; owl:annotatedTarget "Absent/small palm crease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010488 ; owl:annotatedTarget "Absent/underdeveloped palm crease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33303 ; owl:annotatedTarget "group VI elements" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010489 ; owl:annotatedTarget "The absence of the major creases of the palm (distal transverse crease, proximal transverse crease, or thenar crease)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010489 ; owl:annotatedTarget "Absent palm lines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010490 ; owl:annotatedTarget "An abnormality of the creases of the skin of palm of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010490 ; owl:annotatedTarget "Abnormality of the palm lines" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010491 ; owl:annotatedTarget "A narrow segment of significantly reduced circumference of a digit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010492 ; owl:annotatedTarget "Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as \"Symphalangism\"." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33304 ; owl:annotatedTarget "chalcogen molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010493 ; owl:annotatedTarget "An abnormally increased length of the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010493 ; owl:annotatedTarget "Elongated long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010494 ; owl:annotatedTarget "Shortening of the legs predominantly affecting terminal parts of the leg in relation to the upper and middle arm segments." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010495 ; owl:annotatedTarget "Amniotic constriction rings affecting the legs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33304 ; owl:annotatedTarget "chalcogen compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010496 ; owl:annotatedTarget "Abnormal increase in size of the lower limbs (due to an increase of the size of cells)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010497 ; owl:annotatedTarget "A developmental defect in which the legs are fused together." . [] a owl:Axiom ; rdfs:label "Sympodia" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0010497 ; owl:annotatedTarget "MEDDRA:10049216" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010498 ; owl:annotatedTarget "A developmental defect that occurs if the two halves of the patella fail to fuse in early childhood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33304 ; owl:annotatedTarget "chalcogen molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010499 ; owl:annotatedTarget "The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar subluxation refers to an unstable kneecap that does not slide centrally within its groove, i.e., a partial dislocation of the patella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010499 ; owl:annotatedTarget "Partial knee cap dislocation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010500 ; owl:annotatedTarget "The ability of the knee joint to extend beyond its normal range of motion (the lower leg is moved beyond a straight position with respect to the thigh)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010501 ; owl:annotatedTarget "An abnormal limitation of knee joint mobility." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010501 ; owl:annotatedTarget "Limitation of knee mobility" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010501 ; owl:annotatedTarget "Limited knee movement" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "group 14 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010502 ; owl:annotatedTarget "A bending or abnormal curvature of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010502 ; owl:annotatedTarget "Bowed calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "carbon group element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010503 ; owl:annotatedTarget "Duplication of the fibula. This may occur as a part of diplopodia (accessory tarsal or metatarsal bone). Diplopodia with double fibula is an extremely rare condition." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010503 ; owl:annotatedTarget "Duplicated calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "carbon group elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010504 ; owl:annotatedTarget "An abnormal increase in the length of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010504 ; owl:annotatedTarget "Increased length of shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010504 ; owl:annotatedTarget "Increased length of shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010505 ; owl:annotatedTarget "An abnormal limitation of the mobility of the ankle joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010506 ; owl:annotatedTarget "An abnormality of dermatoglyphs on the toes and soles, i.e., an abnormality of the patterns of ridges of the skin of sole of foot." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010506 ; owl:annotatedTarget "Abnormal prints on feet" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "carbonoides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010507 ; owl:annotatedTarget "A difference in size or shape between the left and right foot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010508 ; owl:annotatedTarget "A condition in which the anterior part of the foot rotates outward away from the midline of the body and the heel remains straight." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "GLYCINE" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "cristallogene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010509 ; owl:annotatedTarget "Absence of the tarsal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010509 ; owl:annotatedTarget "Absent ankle bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "cristallogenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010510 ; owl:annotatedTarget "An ability of the toe joints to move beyond their normal range of motion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33306 ; owl:annotatedTarget "group IV elements" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010511 ; owl:annotatedTarget "Toes that appear disproportionately long compared to the foot." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010511 ; owl:annotatedTarget "Increased length of toes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010511 ; owl:annotatedTarget "Long toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33308 ; owl:annotatedTarget "Carboxylic ester" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010511 ; owl:annotatedTarget "Long toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010512 ; owl:annotatedTarget "Calcification within the adrenal glands." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33308 ; owl:annotatedTarget "carboxylic esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010513 ; owl:annotatedTarget "Deposition of calcium salts in the pituitary gland." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33308 ; owl:annotatedTarget "a carboxylic ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010514 ; owl:annotatedTarget "Hypersecretion of one or more pituitary hormones. This can occur in conditions in which deficiency in the target organ leads to decreased hormonal feedback, or as a primary condition most usually in connection with a pituitary adenoma." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33308 ; owl:annotatedTarget "carboxylic acid esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010515 ; owl:annotatedTarget "Absence or underdevelopment of the thymus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010515 ; owl:annotatedTarget "Absent/small thymus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010515 ; owl:annotatedTarget "Absent/underdeveloped thymus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010515 ; owl:annotatedTarget "Thymic hypoplasia or aplasia" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33318 ; owl:annotatedTarget "main group elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010516 ; owl:annotatedTarget "Enlargement of the thymus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010516 ; owl:annotatedTarget "Enlarged thymus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33318 ; owl:annotatedTarget "Hauptgruppenelement" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33318 ; owl:annotatedTarget "Hauptgruppenelemente" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010517 ; owl:annotatedTarget "The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010517 ; owl:annotatedTarget "Abnormal thymus position" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010518 ; owl:annotatedTarget "An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010519 ; owl:annotatedTarget "An abnormal increase in quantity or strength of fetal movements." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010519 ; owl:annotatedTarget "Foetal hyperkinesia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010519 ; owl:annotatedTarget "Increased foetal movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010521 ; owl:annotatedTarget "Gait apraxia affecting the ability to make walking movements with the legs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010522 ; owl:annotatedTarget "A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010522 ; owl:annotatedTarget "Reading disability" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010523 ; owl:annotatedTarget "An acquired type of sensory aphasia where damage to the brain leads to the loss of the ability to read." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Glycine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33318 ; owl:annotatedTarget "main group element" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010523 ; owl:annotatedTarget "Text blindness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010523 ; owl:annotatedTarget "Word blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010524 ; owl:annotatedTarget "Inability to recognize objects not because of sensory deficit but because of the inability to combine components of sensory impressions into a complete pattern. Thus, agnosia is a neurological condition which results in an inability to know, to name, to identify, and to extract meaning from visual, auditory, or tactile impressions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010525 ; owl:annotatedTarget "An inability or difficulty differentiating among the fingers of either hand as well as the hands of others." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010526 ; owl:annotatedTarget "A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010527 ; owl:annotatedTarget "Inability to recognize the form of objects by touch without visual input. That is, an impairment in the recognition of objects based only on the texture, size, weight and three-dimensional form of the object in the absence of any major somatosensory deficit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010528 ; owl:annotatedTarget "Inability to recognize faces of familiar persons." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010528 ; owl:annotatedTarget "Face blindness" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33340 ; owl:annotatedTarget "group 12 elements" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010529 ; owl:annotatedTarget "Echoing another person's speech" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010529 ; owl:annotatedTarget "Echologia" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010529 ; owl:annotatedTarget "Echophrasia" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010529 ; owl:annotatedTarget "Repeated speech" . [] oboInOwl:hasDbXref , "PMID:33101766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010530 ; owl:annotatedTarget "Palatal tremor (PT) is an involuntary, rhythmic and oscillatory movement of the soft palate. PT is a rare type of tremor involving the soft palate. It can be unilateral or bilateral." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33340 ; owl:annotatedTarget "zinc group element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010531 ; owl:annotatedTarget "Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010532 ; owl:annotatedTarget "Paroxysmal episodes of vertigo." . [] oboInOwl:hasDbXref , "PMID:7499100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010533 ; owl:annotatedTarget "The combination of pendular nystagmus, head nodding, and torticollis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010534 ; owl:annotatedTarget "A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010535 ; owl:annotatedTarget "An intermittent cessation of airflow at the mouth and nose during sleep. Apneas of at least 10 seconds are considered important, but persons with sleep apnea may have apneas of 20 seconds to up to 2 or 3 minutes. Patients may have up to 15 events per hour of sleep." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010535 ; owl:annotatedTarget "Pauses in breathing while sleeping" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010536 ; owl:annotatedTarget "Sleep apnea resulting from a transient abolition of the central drive to the ventilatory muscles." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33340 ; owl:annotatedTarget "zinc group elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010537 ; owl:annotatedTarget "An abnormally increased width of the cranial sutures for age-related norms (generally resulting from delayed closure)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010537 ; owl:annotatedTarget "Broad cranial sutures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010537 ; owl:annotatedTarget "Large cranial suture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010537 ; owl:annotatedTarget "Persistent open cranial sutures" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33356 ; owl:annotatedTarget "group 8 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "An abnormally small sella turcica." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "Hypoplasia of sella turcica" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "Hypoplasia of hypophseal fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "Hypoplasia of pituitary fossa" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "Small hypophyseal fossa" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33356 ; owl:annotatedTarget "iron group element" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010538 ; owl:annotatedTarget "Small pituitary fossa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010539 ; owl:annotatedTarget "The presence of an abnormally thin calvarium." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010539 ; owl:annotatedTarget "Thin skull bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33356 ; owl:annotatedTarget "iron group elements" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010539 ; owl:annotatedTarget "Thin cranial bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010540 ; owl:annotatedTarget "A degree of pneumatization that is increased compared to age-related norms." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "The presence of convoluted folds and furrows formed from thickened skin of the scalp, resembling cerebriform pattern. The scalp has convoluted and elevated folds, 1 to 2 cm in thickness. The convolutions generally cannot be flattened by traction." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "Scalp folds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "Scalp furrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "Furrows in thickened skin on top of scalp" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "Thickened folds on top of scalp" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010541 ; owl:annotatedTarget "Thickening of the scalp" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010542 ; owl:annotatedTarget "Nystagmus due to disturbance of the vestibular system; eye movements are rhythmic, with slow and fast components." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010543 ; owl:annotatedTarget "Bursts of large-amplitude multidirectional saccades without intersaccadic interval" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33358 ; owl:annotatedTarget "group 9 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010544 ; owl:annotatedTarget "Vertical nystagmus may present with either up-beating or down-beating eye movements or both. When present in the straight-ahead position of gaze it is referred to as upbeat nystagmus or downbeat nystagmus." . [] oboInOwl:hasDbXref , "PMID:21505601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010545 ; owl:annotatedTarget "Downbeat nystagmus is a type of fixation nystagmus with the fast phase beating in a downward direction. It generally increases when looking to the side and down and when lying prone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010546 ; owl:annotatedTarget "Fine, rapid twitching of individual muscle fibers with little or no movement of the muscle as a whole. If a motor neuron or its axon is destroyed, the muscle fibers it innervates undergo denervation atrophy. This leads to hypersensitivity of individual muscle fibers to acetyl choline so that they may contract spontaneously. Isolated activity of individual muscle fibers is generally so fine it cannot be seen through the intact skin, although it can be recorded as a short-duration spike in the EMG." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010546 ; owl:annotatedTarget "Twitching" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010547 ; owl:annotatedTarget "A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010548 ; owl:annotatedTarget "A localized myotonic contraction in a muscle in reaction to percussion (tapping with the examiner's finger, a rubber percussion hammer, or a similar object)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010549 ; owl:annotatedTarget "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010550 ; owl:annotatedTarget "Severe or complete weakness of both lower extremities with sparing of the upper extremities." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010550 ; owl:annotatedTarget "Leg paralysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010551 ; owl:annotatedTarget "Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33358 ; owl:annotatedTarget "cobalt group element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010553 ; owl:annotatedTarget "An acute dystonic reaction with blepharospasm, periorbital twitches, and protracted fixed staring episodes. There may be a maximal upward deviation of the eyes in the sustained fashion. Oculogyric crisis can be triggered by a number of factors including neuroleptic medications." . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010554 ; owl:annotatedTarget "A soft tissue continuity in the A/P axis between two fingers that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two fingers that lies significantly distal to the flexion crease that overlies the metacarpophalangeal joint of the adjacent fingers." . [] oboInOwl:hasDbXref "PMID:16200145" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010554 ; owl:annotatedTarget "Webbed fingers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010554 ; owl:annotatedTarget "Webbed skin of fingers" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33358 ; owl:annotatedTarget "cobalt group elements" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010557 ; owl:annotatedTarget "A finger resting on the dorsal surface of an adjacent digit when the hand is at rest." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "aminoacetic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33366 ; owl:annotatedTarget "group 11 elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010558 ; owl:annotatedTarget "An abnormality of the clivus, which is the inclined bony region of the posterior cranial fossa located between the sella turcica and the foramen magnum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010559 ; owl:annotatedTarget "An abnormal vertical orientation of the clivus (which normally forms a kind of slope from the sella turcica down to the region of the foramen magnum)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33366 ; owl:annotatedTarget "coinage metals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010560 ; owl:annotatedTarget "An abnormally wavy surface or edge of the clavicles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010560 ; owl:annotatedTarget "Wavy collarbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33366 ; owl:annotatedTarget "copper group element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010561 ; owl:annotatedTarget "An abnormally wavy surface or edge of the ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010561 ; owl:annotatedTarget "Wavy ribs" . [] a owl:Axiom ; rdfs:label "Keloid scar" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0010562 ; owl:annotatedTarget "MEDDRA:10023330" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33366 ; owl:annotatedTarget "copper group elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010564 ; owl:annotatedTarget "A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33402 ; owl:annotatedTarget "oxoacids of sulfur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010565 ; owl:annotatedTarget "This term applies if the Epiglottis is absent or hypoplastic." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33402 ; owl:annotatedTarget "sulfur oxoacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010566 ; owl:annotatedTarget "A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010567 ; owl:annotatedTarget "Y-shaped metatarsals are the result of a partial fusion of two metatarsal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metatarsals may be seen in combination with polydactyly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010567 ; owl:annotatedTarget "Y-shaped long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010568 ; owl:annotatedTarget "A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the eye." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33405 ; owl:annotatedTarget "hydracid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010569 ; owl:annotatedTarget "Concentration of 7-dehydrocholesterol in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010570 ; owl:annotatedTarget "An abnormally low concentration of serum alpha-fetoprotein as compared to normal values for gestational-age." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33405 ; owl:annotatedTarget "hydracids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010570 ; owl:annotatedTarget "Low maternal serum alpha-fetoprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010571 ; owl:annotatedTarget "An abnormal elevation of phytanic acid." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010571 ; owl:annotatedTarget "Elevated levels of phytanic acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "glycine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33408 ; owl:annotatedTarget "pnictogen oxoacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010574 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010574 ; owl:annotatedTarget "Abnormality of the end part of the innermost thighbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33424 ; owl:annotatedTarget "sulfur oxoacid derivative" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010575 ; owl:annotatedTarget "The presence of developmental dysplasia of the femoral head." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010575 ; owl:annotatedTarget "Abnormality of femoral head development" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33424 ; owl:annotatedTarget "sulfur oxoacid derivatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010576 ; owl:annotatedTarget "A cystic lesion originating within the brain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33429 ; owl:annotatedTarget "monoatomic monoanions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010577 ; owl:annotatedTarget "Absent end part of bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33432 ; owl:annotatedTarget "atomic chlorine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010578 ; owl:annotatedTarget "Bracket shaped end part of long bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33433 ; owl:annotatedTarget "monoatomic halogens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010579 ; owl:annotatedTarget "Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010579 ; owl:annotatedTarget "Cone-shaped end part of bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33434 ; owl:annotatedTarget "elemental halogen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010580 ; owl:annotatedTarget "Increased size of epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010580 ; owl:annotatedTarget "Large end part of bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010582 ; owl:annotatedTarget "An alteration of the normally smooth contour of the epiphysis leading to an irregular appearance." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33434 ; owl:annotatedTarget "elemental halogens" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010582 ; owl:annotatedTarget "Irregular end part of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010583 ; owl:annotatedTarget "Sclerosis of the epiphyses, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010583 ; owl:annotatedTarget "Increased bone density in end part of bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33452 ; owl:annotatedTarget "benzylic group" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010585 ; owl:annotatedTarget "Reduction in the size or volume of epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010585 ; owl:annotatedTarget "Small end part of bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33452 ; owl:annotatedTarget "benzylic groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010587 ; owl:annotatedTarget "Triangular end part of bone" . [] oboInOwl:hasDbXref , "PMID:12624140" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010588 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at each end of a long bone, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Aminoacetic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33452 ; owl:annotatedTarget "benzylic groups" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010590 ; owl:annotatedTarget "Any abnormality of the distal epiphysis of the femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010590 ; owl:annotatedTarget "Abnormality of the end part of the outermost thighbone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33452 ; owl:annotatedTarget "groupe benzylique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010591 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010591 ; owl:annotatedTarget "Abnormality of the end part of innermost shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010591 ; owl:annotatedTarget "Abnormality of the end part of innermost shinbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33457 ; owl:annotatedTarget "phosphorus oxoacid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010592 ; owl:annotatedTarget "Abnormality of the end part of outermost shankbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010592 ; owl:annotatedTarget "Abnormality of the end part of outermost shinbone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33457 ; owl:annotatedTarget "Oxosaeure des Phosphors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010593 ; owl:annotatedTarget "Abnormality of the end part of the calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33457 ; owl:annotatedTarget "oxoacids of phosphorus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010594 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010594 ; owl:annotatedTarget "Abnormality of the innermost end part of calf bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33457 ; owl:annotatedTarget "phosphorus oxoacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010595 ; owl:annotatedTarget "Any abnormality of the distal epiphysis of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010595 ; owl:annotatedTarget "Abnormality of the outermost end part of calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010596 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33459 ; owl:annotatedTarget "pnictogen oxoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010597 ; owl:annotatedTarget "Any abnormality of the distal epiphysis of the radius." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33459 ; owl:annotatedTarget "pnictogen oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010598 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010598 ; owl:annotatedTarget "Abnormality of the end part of the innermost long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33461 ; owl:annotatedTarget "phosphorus oxoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010599 ; owl:annotatedTarget "Any abnormality of the distal epiphysis of the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010599 ; owl:annotatedTarget "Abnormality of the end part of the outermost long bone in upper arm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33461 ; owl:annotatedTarget "oxoanions of phosphorus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010600 ; owl:annotatedTarget "Any abnormality of the distal epiphysis of the ulna." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Aminoessigsaeure" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33461 ; owl:annotatedTarget "phosphorus oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010601 ; owl:annotatedTarget "Any abnormality of the proximal epiphysis of the ulna." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010602 ; owl:annotatedTarget "An abnormal predominance of type II muscle fibers (in general, this feature can only be observed on muscle biopsy)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010602 ; owl:annotatedTarget "Type 2 muscle fibre predominance" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010602 ; owl:annotatedTarget "Type II muscle fibre predominance" . [] oboInOwl:hasDbXref , "PMID:18353202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010603 ; owl:annotatedTarget "A benign uni- or multicystic, intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010603 ; owl:annotatedTarget "Keratocystic odontogenic tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010603 ; owl:annotatedTarget "Keratocysts of the jaw" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33482 ; owl:annotatedTarget "sulfur oxoanion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010604 ; owl:annotatedTarget "Lesion of the eyelid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33482 ; owl:annotatedTarget "oxoanions of sulfur" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010604 ; owl:annotatedTarget "Cyst of the eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010604 ; owl:annotatedTarget "Eyelid bump" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010604 ; owl:annotatedTarget "Eyelid mass" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010605 ; owl:annotatedTarget "A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010605 ; owl:annotatedTarget "Meibomian gland lipogranuloma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010606 ; owl:annotatedTarget "An acute purulent infection of the sebaceous glands of Zeis at the base of the eyelashes, of the apocrine sweat glands of Moll or the meibomian sebacious glands often caused by staphylococcus infections. Hordeola can either occur as Hordeola externa affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll or as Hordeola interna affecting the meibomian sebacious glands. In contrast to chalazia, hordeola are extremely painful and can cause extreme local swelling." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010606 ; owl:annotatedTarget "Stye of eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010606 ; owl:annotatedTarget "Red bump on eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010607 ; owl:annotatedTarget "Hordeola externa are acute purulent infections affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll, often caused by staphylococcus infections. In contrast to chalazia, hordeola are extremely painfull and can cause extreme local swelling." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010608 ; owl:annotatedTarget "Hordeola interna are acute purulent infections affecting the meibomian sebacious glands, often caused by staphylococcus infections. In contrast to chalazia (chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland), hordeola are extremely painfull and can cause extreme local swelling." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33482 ; owl:annotatedTarget "sulfur oxoanions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010608 ; owl:annotatedTarget "Stye of inner eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010608 ; owl:annotatedTarget "Red bump on inner eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010609 ; owl:annotatedTarget "Cutaneous skin tags also known as acrochorda or fibroepithelial polyps are small benign tumors that may either form secondarily over time primarily in areas where the skin forms creases, such as the neck, armpit or groin or may also be present at birth, in which case they usually occur in the periauricular region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010612 ; owl:annotatedTarget "The presence of multiple pits (small, pinpoint-large indentations on the surface of the skin) located on the skin of sole of foot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010614 ; owl:annotatedTarget "Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term \"fibroblastic\" or \"fibromatous\" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010615 ; owl:annotatedTarget "Angiofibroma consist of many often dilated vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010616 ; owl:annotatedTarget "The presence of a lung fibroma, a benign neoplasm that can present as a mass causing airway obstruction, cough, and hemoptysis, or present without symptoms as a solitary pulmonary nodule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010617 ; owl:annotatedTarget "A fibroma of the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010618 ; owl:annotatedTarget "The presence of a fibroma of the ovary." . [] oboInOwl:hasDbXref , "PMID:23396888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010619 ; owl:annotatedTarget "A benign biphasic tumor of the breast with epithelial and stromal components." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010619 ; owl:annotatedTarget "Breast fibroadenomas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010620 ; owl:annotatedTarget "Prominence of the malar process of the maxilla and infraorbital area appreciated in profile and from in front of the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010620 ; owl:annotatedTarget "Hyperplasia of malar bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33484 ; owl:annotatedTarget "chalcogen oxoacid" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010621 ; owl:annotatedTarget "A soft tissue continuity in the anteroposterior axis between adjacent foot digits that involves at least half of the proximodistal length of one of the two involved digits; or, a soft tissue continuity in the A/P axis between two digits of the foot that does not meet the prior objective criteria." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010621 ; owl:annotatedTarget "Webbed skin of toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010622 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the skeleton." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33484 ; owl:annotatedTarget "chalcogen oxoacids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010622 ; owl:annotatedTarget "Skeletal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010622 ; owl:annotatedTarget "Skeletal tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010624 ; owl:annotatedTarget "Absence or underdevelopment of the toenail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010624 ; owl:annotatedTarget "Absent/small toenails" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010624 ; owl:annotatedTarget "Absent/underdeveloped toenails" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33485 ; owl:annotatedTarget "chalcogen oxoanion" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010625 ; owl:annotatedTarget "Absence or underdevelopment of the anterior pituitary gland, also known as the adenohypophysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010625 ; owl:annotatedTarget "Adenohypophysis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33485 ; owl:annotatedTarget "chalcogen oxoanions" . [] oboInOwl:hasDbXref , , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010626 ; owl:annotatedTarget "Absence of the anterior pituitary gland resulting from a developmental defect." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010626 ; owl:annotatedTarget "Absent pituitary gland" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010627 ; owl:annotatedTarget "Underdevelopment of the anterior pituitary gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010627 ; owl:annotatedTarget "Underdeveloped pituitary gland" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "G" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33497 ; owl:annotatedTarget "transition element molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010628 ; owl:annotatedTarget "Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010628 ; owl:annotatedTarget "Bell's palsy" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33497 ; owl:annotatedTarget "transition metal molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010629 ; owl:annotatedTarget "Any abnormality affecting the cortex of the humerus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33504 ; owl:annotatedTarget "alkali metal cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010630 ; owl:annotatedTarget "Any abnormality of a metatarsal bone epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010630 ; owl:annotatedTarget "Abnormality of end part of long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33515 ; owl:annotatedTarget "transition element cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010631 ; owl:annotatedTarget "Any abnormality of the epiphyses of the feet." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010631 ; owl:annotatedTarget "Abnormality of the end part of the foot bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010632 ; owl:annotatedTarget "Inability to detect any qualitative olfactory sensation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010633 ; owl:annotatedTarget "Inability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010634 ; owl:annotatedTarget "Reduced ability to detect any qualitative olfactory sensation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010635 ; owl:annotatedTarget "Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010636 ; owl:annotatedTarget "The presence of a cleft in the cerebral cortex unilaterally or bilaterally, usually located in the frontal area." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33515 ; owl:annotatedTarget "transition metal cation" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "PMID:21784043" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010637 ; owl:annotatedTarget "A form of amyloidosis that affects the conjunctiva." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "elemental metal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010638 ; owl:annotatedTarget "An abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010638 ; owl:annotatedTarget "Elevated ALP of hepatic origin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "elemental metals" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "metal element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010639 ; owl:annotatedTarget "An abnormally increased level of bone isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010639 ; owl:annotatedTarget "Elevated ALP of bone origin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010639 ; owl:annotatedTarget "Elevated alkaline phosphatase of bone origin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010639 ; owl:annotatedTarget "Increased serum bone-specific alkaline phosphatase" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "metal elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010640 ; owl:annotatedTarget "Abnormality of the nasal cavity (the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010641 ; owl:annotatedTarget "Abnormality of the midnasal cavity which includes the cavity between the nares and the choanae." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Gly" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33521 ; owl:annotatedTarget "metals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010643 ; owl:annotatedTarget "Absence or abnormal closure of the midnasal cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010644 ; owl:annotatedTarget "Abnormal narrowing (stenosis) of the midnasal cavity, i.e., of the middle nasal meatus, which in neonates can cause respiratory distress." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010645 ; owl:annotatedTarget "Absence of the distal phalanges of the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010645 ; owl:annotatedTarget "Absent outermost bone of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010646 ; owl:annotatedTarget "An abnormal lack of stability of the cervical spine." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33540 ; owl:annotatedTarget "sulfurothioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010647 ; owl:annotatedTarget "Any abnormal increase or reduction in skin elasticity." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33540 ; owl:annotatedTarget "thiosulfuric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010648 ; owl:annotatedTarget "An abnormally increased ability of the skin to permit light to pass through (translucency) such that subcutaneous structures such as veins display an increased degree of visibility." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010649 ; owl:annotatedTarget "An abnormal degree of flatness of the Ala of nose, which can be defined as a reduced nasal elevation index (lateral depth of the nose from the tip of the nose to the insertion of the nasal ala in the cheek x 100 divided by the side-to-side breadth of the nasal alae)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010649 ; owl:annotatedTarget "Depressed nasal alae" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010649 ; owl:annotatedTarget "Flat nasal alar cartilage" . [] oboInOwl:hasDbXref , , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Decreased size of premaxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Decreased size of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Hypoplasia of the intermaxillary bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Hypoplasia of the primary palate bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Premaxillary bone deficiency" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Premaxillary underdevelopment" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Primary palate bone deficiency" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33541 ; owl:annotatedTarget "hydrogen sulfurothioate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Small premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Small primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Underdevelopment of premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Underdevelopment of the premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Underdevelopment of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Premaxillary bone retrusion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Premaxillary retrusion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010650 ; owl:annotatedTarget "Primary palate bone retrusion" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33541 ; owl:annotatedTarget "HS2O3(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010651 ; owl:annotatedTarget "An abnormality of the Meninges, including any abnormality of the Dura mater, the Arachnoid mater, and the Pia mater." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010652 ; owl:annotatedTarget "An abnormality of the Dura mater." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33543 ; owl:annotatedTarget "Gmelin:971569" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010653 ; owl:annotatedTarget "An abnormality of the Falx cerebri." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010654 ; owl:annotatedTarget "A developmental defect characterized by aplasia of the Falx cerebri." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Glycin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33543 ; owl:annotatedTarget "hydridotrioxidosulfate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010654 ; owl:annotatedTarget "Absent cerebral falx" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010655 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010655 ; owl:annotatedTarget "Speckled calcifications in end part of bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33543 ; owl:annotatedTarget "SHO3(-)" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33543 ; owl:annotatedTarget "[SHO3](-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010656 ; owl:annotatedTarget "An abnormality of the formation and mineralization of an epiphysis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010656 ; owl:annotatedTarget "Abnormal maturation of the end part of a bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010657 ; owl:annotatedTarget "Patchy (irregular) reduction in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010658 ; owl:annotatedTarget "Patchy (irregular) changes in bone mineral density. These changes can either be patchy reduction or increase of mineral density as seen on x-rays. Depending on the pathomechanism and the underlying disease, these changes can either appear solely as reduction or increase or as a combination of both (patches of bone showing an increased density while others are affected by reduction of mineral density)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010659 ; owl:annotatedTarget "Patchy (irregular) changes in bone mineral density with patches of bone showing an increased density side to side with patches that are affected by reduction of mineral density. This is sometimes referred to as a moth-eaten appearance on x-rays." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010659 ; owl:annotatedTarget "Patchy increased and decreased bone mineral density" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33543 ; owl:annotatedTarget "sulfonates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010660 ; owl:annotatedTarget "An abnormality of the formation and mineralization of any bone of the skeleton of hand." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010660 ; owl:annotatedTarget "Abnormal maturation of the hand bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010661 ; owl:annotatedTarget "A developmental defect characterized by the absence of the third ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010662 ; owl:annotatedTarget "An abnormality of the Diencephalon, which together with the cerebrum (telencephalon) makes up the forebrain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010663 ; owl:annotatedTarget "An abnormality of the thalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010663 ; owl:annotatedTarget "Abnormal shape of thalamus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33551 ; owl:annotatedTarget "organosulfonic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010664 ; owl:annotatedTarget "A developmental defect characterized by fusion of the left and right halves of the thalamus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33551 ; owl:annotatedTarget "sulfonic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010665 ; owl:annotatedTarget "The presence of bilateral coxa valga." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Underdevelopment of the anterior nasal spine of maxilla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Decreased projection of anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Decreased size of anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Small anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Underdevelopment of anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Decreased length of anterior nasal spine" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Glycocoll" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33552 ; owl:annotatedTarget "sulfonic acid derivative" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Deficiency of anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010666 ; owl:annotatedTarget "Hypotrophic anterior nasal spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "A congenital defect characterized by absence of the Maxilla." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33552 ; owl:annotatedTarget "derivatives of sulfonic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Failure of development of upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Absence of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Absence of upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Agenesis of the maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Aplasia of the upper jaw bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Failure of development of maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010667 ; owl:annotatedTarget "Missing upper jaw bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33552 ; owl:annotatedTarget "sulfonic acid derivatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "An abnormality of the zygomatic bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "Abnormality of the cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "Anomaly of the zygomatic bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "Deformity of the cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "Deformity of the zygomatic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010668 ; owl:annotatedTarget "Malformation of the zygomatic bone" . [] oboInOwl:hasDbXref , , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Underdevelopment of the zygomatic bone. That is, a reduction in size of the zygomatic bone, including the zygomatic process of the temporal bone of the skull, which forms part of the zygomatic arch." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Depressed cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Depressed zygomatic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Flattening of the zygomatic bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Small cheekbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Small malar bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Small zygomatic bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Cheekbone underdevelopment" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Decreased size of cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Decreased size of zygomatic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Hypoplasia of cheekbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Underdevelopment of cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Underdevelopment of zygomatic bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33554 ; owl:annotatedTarget "organosulfonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Hypotrophic cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Hypotrophic zygomatic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Hypotrophy of the cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010669 ; owl:annotatedTarget "Hypotrophy of the zygomatic bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33554 ; owl:annotatedTarget "organosulfonate oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010672 ; owl:annotatedTarget "An abnormality of the third metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010672 ; owl:annotatedTarget "Abnormality of the 3rd long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33554 ; owl:annotatedTarget "organosulfonates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010674 ; owl:annotatedTarget "The presence of an abnormal curvature of the vertebral column." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010674 ; owl:annotatedTarget "Abnormal curve of the backbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010674 ; owl:annotatedTarget "Abnormal curve of the spine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010675 ; owl:annotatedTarget "An abnormality of the formation and mineralization of any bone of the skeleton of foot." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010675 ; owl:annotatedTarget "Abnormal maturation of foot bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010677 ; owl:annotatedTarget "Enuresis occurring during sleeping hours." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010678 ; owl:annotatedTarget "Enuresis occurring during waking hours of the day." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33558 ; owl:annotatedTarget "alpha-amino-acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010679 ; owl:annotatedTarget "An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Glykokoll" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33558 ; owl:annotatedTarget "alpha-amino acid anions" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010679 ; owl:annotatedTarget "Elevated tissue non-specific ALP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33558 ; owl:annotatedTarget "alpha-amino-acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010680 ; owl:annotatedTarget "An abnormally increased level of kidney isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010680 ; owl:annotatedTarget "Elevated ALP of renal origin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33559 ; owl:annotatedTarget "s-block element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010681 ; owl:annotatedTarget "An abnormally increased level of alkaline phosphatase, intestinal type in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010681 ; owl:annotatedTarget "Elevated intestinal ALP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33559 ; owl:annotatedTarget "s-block elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010682 ; owl:annotatedTarget "An abnormally increased level of alkaline phosphatase, placental type in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010682 ; owl:annotatedTarget "Elevated placental ALP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33560 ; owl:annotatedTarget "p-block element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010683 ; owl:annotatedTarget "An abnormally reduced level of alkaline phosphatase, tissue-nonspecific isozyme in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010683 ; owl:annotatedTarget "Low tissue non-specific ALP" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33560 ; owl:annotatedTarget "p-block elements" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33561 ; owl:annotatedTarget "d-block element" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010684 ; owl:annotatedTarget "An abnormally reduced level of bone isoforms of alkaline phosphatase in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010684 ; owl:annotatedTarget "Low ALP of bone origin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33561 ; owl:annotatedTarget "d-block elements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010685 ; owl:annotatedTarget "An abnormally reduced level of kidney isoforms of alkaline phosphatase in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010685 ; owl:annotatedTarget "Low ALP of renal origin" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33563 ; owl:annotatedTarget "Glycolipid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33563 ; owl:annotatedTarget "glycolipids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010686 ; owl:annotatedTarget "An abnormally reduced level of liver isoforms of alkaline phosphatase in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010686 ; owl:annotatedTarget "Low ALP of hepatic origin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010687 ; owl:annotatedTarget "An abnormally reduced level of alkaline phosphatase, intestinal type in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Glyzin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33566 ; owl:annotatedTarget "1,2-benzenediols" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010687 ; owl:annotatedTarget "Low intestinal ALP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010688 ; owl:annotatedTarget "An abnormally reduced level of alkaline phosphatase, placental type in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010688 ; owl:annotatedTarget "Low placental ALP" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33566 ; owl:annotatedTarget "a catechol" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010689 ; owl:annotatedTarget "A hand or foot with more than five digits that has a recognizable A/P axis of symmetry. The axis can lie within a normally formed or partially duplicated digit resembling a middle finger, index finger, thumb, toe, or hallux. Alternatively, the axis can be in an interdigital space with a flanking pair of digits that resemble a middle finger, index finger, thumb, toe or hallux. The most lateral digits on each side of the hand/foot typically resemble fifth fingers/toes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010690 ; owl:annotatedTarget "Mirror image duplication of digits affecting the hands only." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010690 ; owl:annotatedTarget "Mirror image dupliction of fingers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010691 ; owl:annotatedTarget "Mirror image duplication of digits affecting the feet." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010691 ; owl:annotatedTarget "Mirror image dupliction of toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33566 ; owl:annotatedTarget "benzene-1,2-diols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010692 ; owl:annotatedTarget "Syndactyly with fusion of fingers two to five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010692 ; owl:annotatedTarget "Webbed 2nd-5th fingers" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010692 ; owl:annotatedTarget "Webbed index, middle and little finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010692 ; owl:annotatedTarget "Webbed index, middle and pinkie finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010692 ; owl:annotatedTarget "Webbed index, middle and pinky finger" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:vkumar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010693 ; owl:annotatedTarget "A kind of congenital cataract that is characterized by a hollow sphere of punctate opacities involving the fetal nucleus and that usually occurs bilaterally." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33567 ; owl:annotatedTarget "Catecholamine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010693 ; owl:annotatedTarget "Pulverulent cataract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010694 ; owl:annotatedTarget "A Lamellar cataract with a pulverulent (punctate, \"dust-like\" opacities) appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010695 ; owl:annotatedTarget "A type of congenital cataract in which the opacity follows the anterior or posterior Y suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010696 ; owl:annotatedTarget "A type of Congenital cataract in which the opacities occupy the subcapsular cortex at the anterior or posterior pole of the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010697 ; owl:annotatedTarget "A type of anterior polar cataract which projects as a conical opacity into the anterior chamber." . [] oboInOwl:hasDbXref , "PMID:10634616", "PMID:14059288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010698 ; owl:annotatedTarget "A type of nuclear cataract involving congenital dust-like (pulverulent) opacity of the embryonal and fetal nucleus." . [] oboInOwl:hasDbXref , "PMID:18483562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010699 ; owl:annotatedTarget "A nuclear cataract with a triangular form." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33567 ; owl:annotatedTarget "catecholamines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010701 ; owl:annotatedTarget "An abnormal deviation from normal levels of immunoglobulins in blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010701 ; owl:annotatedTarget "Abnormal serum immunoglobulin levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33567 ; owl:annotatedTarget "catecholamines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010702 ; owl:annotatedTarget "An increased level of gamma globulin (immunoglobulin) in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010704 ; owl:annotatedTarget "Syndactyly with fusion of fingers one and two." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010704 ; owl:annotatedTarget "Webbed 1st-2nd finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010704 ; owl:annotatedTarget "Webbed thumb and index finger" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010705 ; owl:annotatedTarget "Syndactyly with fusion of fingers four and five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010705 ; owl:annotatedTarget "Webbed 4th-5th finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "Beilstein:2212160" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010706 ; owl:annotatedTarget "Syndactyly with fusion of fingers one to three." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010706 ; owl:annotatedTarget "Webbed 1st-3rd finger" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "H2N-CH2-COOH" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "CAS:329-65-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010707 ; owl:annotatedTarget "Syndactyly with fusion of fingers one to four." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010707 ; owl:annotatedTarget "Webbed 1st-4th finger" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "Drug_Central:4508" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010708 ; owl:annotatedTarget "Syndactyly with fusion of fingers one to five (complete syndactyly of all fingers of the hand)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010708 ; owl:annotatedTarget "Webbed 1st-5th fingers" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "Gmelin:51559" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010709 ; owl:annotatedTarget "Syndactyly with fusion of the fingers two to four." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010709 ; owl:annotatedTarget "Webbed index through ring fingers" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "PMID:10052027" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010710 ; owl:annotatedTarget "Syndactyly with fusion of fingers three to five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010710 ; owl:annotatedTarget "Webbed third, fourth and fifth toes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "PMID:24252294" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010711 ; owl:annotatedTarget "Syndactyly with fusion of toes one and two." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "PMID:24719616" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010711 ; owl:annotatedTarget "Webbed first and second toes" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "Reaxys:2212160" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010712 ; owl:annotatedTarget "Syndactyly with fusion of toes one to four." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010712 ; owl:annotatedTarget "Webbed first through fourth toes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "rac-4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010713 ; owl:annotatedTarget "Syndactyly with fusion of toes one to five (complete syndactyly of all toes of the foot)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010713 ; owl:annotatedTarget "Webbed 1st-5th toes" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "(+-)-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010714 ; owl:annotatedTarget "Syndactyly with fusion of toes two to four." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010714 ; owl:annotatedTarget "Webbed 2nd-4th toes" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "(+-)-epinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010715 ; owl:annotatedTarget "Syndactyly with fusion of toes two to five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010715 ; owl:annotatedTarget "Webbed 2nd-5th toes" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Hgly" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "2-(methylamino)-1-(3,4-dihydroxyphenyl)ethanol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010716 ; owl:annotatedTarget "Syndactyly with fusion of toes three to five." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010716 ; owl:annotatedTarget "Webbed 3rd-5th toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010717 ; owl:annotatedTarget "Webbing or fusion of the toes, involving soft parts and including fusion of individual bones of the toes. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a tibial-fibular axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\"." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "dl-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010719 ; owl:annotatedTarget "An abnormality of the texture of the hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010719 ; owl:annotatedTarget "Abnormality of hair texture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010719 ; owl:annotatedTarget "Abnormality of hair consistency" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010719 ; owl:annotatedTarget "Abnormality of hair curl pattern" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010719 ; owl:annotatedTarget "Abnormality of hair volume" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "epinephrine racemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010720 ; owl:annotatedTarget "An abnormality of the distribution of hair growth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010720 ; owl:annotatedTarget "Abnormal distribution of hair" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010720 ; owl:annotatedTarget "Abnormal hair pattern" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "rac-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010721 ; owl:annotatedTarget "An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010721 ; owl:annotatedTarget "Abnormal hair whorl" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010721 ; owl:annotatedTarget "Abnormal hair whorls" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010721 ; owl:annotatedTarget "Abnormal whorl of hair" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "racemic adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010722 ; owl:annotatedTarget "An asymmetriy, i.e., difference in size, shape or position between the left and right ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010722 ; owl:annotatedTarget "Asymmetric ears" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010724 ; owl:annotatedTarget "An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "racepinefrina" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010726 ; owl:annotatedTarget "Abnormal prominence of the corneal nerve fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010726 ; owl:annotatedTarget "Prominent corneal nerve fibres" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010726 ; owl:annotatedTarget "Visible corneal nerve fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010727 ; owl:annotatedTarget "Rupture of the eyeball not due to trauma." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "racepinefrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010728 ; owl:annotatedTarget "A developmental defect characterized by absence of the retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010728 ; owl:annotatedTarget "Absent retina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010729 ; owl:annotatedTarget "Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparancy of the macula." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33568 ; owl:annotatedTarget "racepinefrinum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010730 ; owl:annotatedTarget "This may present as a partial or complete duplication of the eyebrows." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010730 ; owl:annotatedTarget "Double eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010730 ; owl:annotatedTarget "Duplication of eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010731 ; owl:annotatedTarget "The eyebrows extend towards - or even all the way down to - the margin of the upper eyelid." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010731 ; owl:annotatedTarget "Extension of eyebrows towards upper eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010732 ; owl:annotatedTarget "Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010732 ; owl:annotatedTarget "Eyelid nodules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010733 ; owl:annotatedTarget "Naevus flammeus localised in the skin of the eyelid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010733 ; owl:annotatedTarget "Port-wine stain on eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010734 ; owl:annotatedTarget "Tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone or bones may be involved. Fibrous dysplasia can either effect isolated bones (Monostotic fibrous dysplasia) or also generalized all bones of the body (Polyostotic fibrous dysplasia)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010735 ; owl:annotatedTarget "Fibrous dysplasia of the bones were lesions are localized in many bones throughout of the body. Polyostotic fibrous dysplasia is a cardinal feature of McCune-Albright syndrome." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010736 ; owl:annotatedTarget "Fibrous dysplasia of the bones were lesions are localized in only one bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010739 ; owl:annotatedTarget "Osteopoikilosis is a benign, asymptomatic sclerotic dysplasia of the bones. It affects both male and female and may be seen at any age. Radiographically sclerotic circular or ovoid lesions are usually symmetrically distributed in a periarticular location. Lesions can increase or decrease in size and number in serial radiographs or even disappear and do not have increased bone radiotracer uptake." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010740 ; owl:annotatedTarget "A lamellar pattern visible on radiographs and mainly localized at the metaphyses of the long tubular bones. Pathologic-anatomical studies revealed that these benign signs on x-rays are the result of a juvenile metaphyseal bone necrosis. Calcifications in the necrotic marrow lead to this lamellar or lattice-like appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Fluid accumulation in lower limbs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Leg oedema" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Lower leg swelling" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Oedema of the lower limbs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Pedal oedema" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Peripheral oedema of lower extremity" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010741 ; owl:annotatedTarget "Dependant oedema" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "Leimzucker" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "Beilstein:2210994" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010742 ; owl:annotatedTarget "An abnormal accumulation of fluid beneath the skin of the arms." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010742 ; owl:annotatedTarget "Fluid accumulation in upper limbs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010742 ; owl:annotatedTarget "Oedema of the upper limbs" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "CAS:138-65-8" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010743 ; owl:annotatedTarget "Diminished length of a metatarsal bone, with resultant proximal displacement of the associated toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010743 ; owl:annotatedTarget "Short long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010743 ; owl:annotatedTarget "Short metatarsal bones" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "CAS:138-65-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010744 ; owl:annotatedTarget "A developmental abnormality characterized by the absence (aplasia) of a metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010744 ; owl:annotatedTarget "Absent long bone of foot" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "Gmelin:863925" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010745 ; owl:annotatedTarget "Absence of a digit or of one or more phalanges of a toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010745 ; owl:annotatedTarget "Absent bones of the toes" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010746 ; owl:annotatedTarget "Small toe bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010747 ; owl:annotatedTarget "An abnormal distribution of eyebrow hair growth in the medial direction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "noradrenalina" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010748 ; owl:annotatedTarget "Positioning of a lacrimal punctum other than at the medial margins of the eyelid." . [] oboInOwl:hasDbXref "PMID:3207663" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010749 ; owl:annotatedTarget "Blepharochalasis is characterized by recurrent, non-painful, nonerythematous episodes of eyelid edema. It has been divided into hypertrophic and atrophic forms. In the hypertrophic form recurrent edema results in orbital fat herniation through a weakened orbital septum. Most patients who have blepharochalasis present in an atrophic condition with atrophy of redundant eyelid skin and superior nasal fat pads." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010749 ; owl:annotatedTarget "Saggy upper eyelid skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Loss of elasticity of the upper and lower eyelids causing the skin to sag and bulge." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Baggy eyes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Droopy eyelid skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33569 ; owl:annotatedTarget "norepinephrine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Extra eyelid skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Redundant eyelid skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010750 ; owl:annotatedTarget "Hooding of eyelids" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "A persistent midline depression of the skin over the fat pad of the chin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Chin butt" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Chin dent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Chin dimple" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Chin skin dimple" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Dimple chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Gelasin of chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Indentation of chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010751 ; owl:annotatedTarget "Chin dimples" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010752 ; owl:annotatedTarget "Midline deficiency of the mandible and some or all overlying tissues." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010752 ; owl:annotatedTarget "Cleft lower jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010752 ; owl:annotatedTarget "Mandibular cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010753 ; owl:annotatedTarget "Midline cleft of mandible" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "PMID:17147560" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "An anomaly of the temporomandibular joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Abnormality of the jaw joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Anomaly of the temporomandibular joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Deformity of the jaw joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Malformation of jaw joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Deformity of the temporomandibular joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Derangement of the temporomandibular joint" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010754 ; owl:annotatedTarget "Malformation of the temporomandibular joint" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "aminoethanoic acid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "PMID:18433345" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Asymmetry between the left and right sides of the maxilla." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Asymmetry of the upper jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Asymmetry of upper jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Crooked upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Asymmetry of right and left side of the maxilla" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Canted maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Canted upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Crooked maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Tilted maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Tilted upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Unequal sides of maxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Uneven maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Uneven upper jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Deviation of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010755 ; owl:annotatedTarget "Deviation of the upper jaw" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010756 ; owl:annotatedTarget "Absence or underdevelopment of the premaxilla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010756 ; owl:annotatedTarget "Aplasia/hypoplasia of the intermaxillary bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010756 ; owl:annotatedTarget "Aplasia/hypoplasia of the primary palate bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "Carbonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Absence of the premaxilla, which is the embryonic structure that forms the anterior part of the maxilla." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Absence of the intermaxillary bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Absence of the premaxilla" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "Carbonsaeuren" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Absence of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Aplasia of the intermaxillary bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Aplasia of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Failure of development of premaxilla" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Failure of development of the primary palate bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Missing premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010757 ; owl:annotatedTarget "Missing primary palate bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "Karbonsaeure" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010758 ; owl:annotatedTarget "An abnormality of the premaxilla, the most anterior part of the maxilla that usually bears the central and lateral incisors and includes the anterior nasal spine and inferior aspect of the piriform rim. The premaxilla contains the bone and teeth of the primary palate." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010758 ; owl:annotatedTarget "Abnormality of the intermaxillary bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010758 ; owl:annotatedTarget "Abnormality of the intermaxillary segment of the maxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010758 ; owl:annotatedTarget "Abnormality of the premaxillary bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010758 ; owl:annotatedTarget "Abnormality of the primary palate bone" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "RC(=O)OH" . [] oboInOwl:hasDbXref , , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Prominent positioning of the premaxilla in relation to the rest of the maxilla, the facial skeleton, or mandible. Not necessarily caused by an increase in size (hypertrophy of) the premaxilla." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Anterior position of the premaxilla" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Anterior position of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Premaxillary bone excess" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "acide carboxylique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Prominence of the intermaxillary bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010759 ; owl:annotatedTarget "Prominence of the primary palate bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010760 ; owl:annotatedTarget "Aplasia of a toe. That is, absence of all phalanges of a non-hallux digit of the foot and the associated soft tissues." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "acides carboxyliques" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010760 ; owl:annotatedTarget "Absent toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010760 ; owl:annotatedTarget "Absent toes" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010761 ; owl:annotatedTarget "Increased width of the columella." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "acido carboxilico" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010761 ; owl:annotatedTarget "Fullness of columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010761 ; owl:annotatedTarget "Increased width of columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010761 ; owl:annotatedTarget "Hyperplasia of columella" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010762 ; owl:annotatedTarget "A chordoma is a tumor that arises from embryonic remnants of the notochord along the length of the neuraxis. Chordomas generally occur in the sacrum, intracranially at the clivus, or along the spinal axis." . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010763 ; owl:annotatedTarget "Insertion of the posterior columella below the nasal base." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010763 ; owl:annotatedTarget "Ala higher than columella" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15428 ; owl:annotatedTarget "aminoethanoic acid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33575 ; owl:annotatedTarget "acidos carboxilicos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010764 ; owl:annotatedTarget "Decreased length of the eyelashes (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010764 ; owl:annotatedTarget "Decreased length of eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010764 ; owl:annotatedTarget "Short eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010765 ; owl:annotatedTarget "Abnormal thickening of the skin localized to the palm of the hand." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010766 ; owl:annotatedTarget "Deposition of calcium salts in a tissue or location in which calcification does not normally occur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010767 ; owl:annotatedTarget "The presence of a cyst, fistula, or abscess in the sacrococcygeal region (gluteal crease) characteristically accompanied by hair and skin folds." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010769 ; owl:annotatedTarget "A sinus in the coccygeal region (the region of the intergluteal cleft). A pilonidal sinus often contains hair and skin debris." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33576 ; owl:annotatedTarget "S-containing carboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010771 ; owl:annotatedTarget "A hair-containing cyst or sinus usually in the coccygeal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010772 ; owl:annotatedTarget "A developmental defect characterized by abnormal connection of one or more pulmonary veins to the superior or inferior vena cava, the right atrium, or the coronary sinus, resulting in a left-to-right shunt of oxygenated blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010773 ; owl:annotatedTarget "A form of anomalous pulmonary venous return in which not all pulmonary veins drain abnormally. Partial anomalous pulmonary venous return frequently involves one or both of the veins from one lung." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010774 ; owl:annotatedTarget "The presence of an additional membrane in the left or right cardiac atrium which results in the subdivision of the affected atrium (and thus in total three atria, whence the name)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010775 ; owl:annotatedTarget "A developmental defect of the aortic arch system in which the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches. This occurs if the normal process of regression and persistence of the bilateral embryonic aortic arches fails." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33576 ; owl:annotatedTarget "S-containing carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010776 ; owl:annotatedTarget "Marked widening of the trachea and major bronchi that may be predispose to chronic respiratory tract infection." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33576 ; owl:annotatedTarget "sulfur-containing carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010777 ; owl:annotatedTarget "Marked widening of the major bronchi that may be predispose to chronic respiratory tract infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010778 ; owl:annotatedTarget "Marked widening of the trachea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010779 ; owl:annotatedTarget "The presence of an abnormally large pelvis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010779 ; owl:annotatedTarget "Large pelvis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33579 ; owl:annotatedTarget "main group compounds" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010779 ; owl:annotatedTarget "Large pelvis bone" . [] oboInOwl:hasDbXref "PMID:14645606", "PMID:14647932", "PMID:31669363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010780 ; owl:annotatedTarget "Over-sensitivity to certain frequency ranges of sound." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010781 ; owl:annotatedTarget "Skin dimples are cutaneous indentations that are the result of tethering of the skin to underlying structures (bone) causing an indentation." . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010781 ; owl:annotatedTarget "Skin dimples" . [] oboInOwl:hasDbXref , "PMID:22679172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010782 ; owl:annotatedTarget "A subtype of skin dimples occurring in the shoulder region." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010782 ; owl:annotatedTarget "Bi-acromial dimples" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010782 ; owl:annotatedTarget "Shoulder dimples" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010783 ; owl:annotatedTarget "Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010783 ; owl:annotatedTarget "Redness of skin or mucous membrane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010784 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the uterus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33579 ; owl:annotatedTarget "main group molecular entities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010784 ; owl:annotatedTarget "Uterine cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010784 ; owl:annotatedTarget "Uterine tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010784 ; owl:annotatedTarget "Uterine tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010785 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of a gonad." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010786 ; owl:annotatedTarget "The presence of a neoplasm of the urinary system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010787 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the genital system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010787 ; owl:annotatedTarget "Genital tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010787 ; owl:annotatedTarget "Genital tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010788 ; owl:annotatedTarget "The presence of a neoplasm of the testis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010788 ; owl:annotatedTarget "Testicular cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010788 ; owl:annotatedTarget "Testicular tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010788 ; owl:annotatedTarget "Testicular tumour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33582 ; owl:annotatedTarget "carbon group molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010790 ; owl:annotatedTarget "Underdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33582 ; owl:annotatedTarget "carbon group molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010791 ; owl:annotatedTarget "Hypertrophy or overdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33595 ; owl:annotatedTarget "cyclic compounds" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010793 ; owl:annotatedTarget "A digit with two nails, with at least some soft tissue between them." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010793 ; owl:annotatedTarget "Notched nail" . [] oboInOwl:hasDbXref , "PMID:10521286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010794 ; owl:annotatedTarget "Reduced ability affecting mainly visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales, which test a person's strengths and weaknesses across a range of intellectual abilities)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33597 ; owl:annotatedTarget "homocyclic compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010795 ; owl:annotatedTarget "A glioma affecting the cerebellum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33597 ; owl:annotatedTarget "homocyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010796 ; owl:annotatedTarget "A glioma affecting the brainstem." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010797 ; owl:annotatedTarget "A hemangioblastoma is a benign vascular neoplasm that arises almost exclusively in the central nervous system. Hemangioblastomas consist of a tightly packed cluster of small blood vessels forming a mass of up to 1 or 2 cm in diameter." . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010798 ; owl:annotatedTarget "Increased focal pigmentation of the vermilion of the lips." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010798 ; owl:annotatedTarget "Ephelis of lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010798 ; owl:annotatedTarget "Lip freckle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010799 ; owl:annotatedTarget "A neoplasm of the pineal gland." . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Lack of paramedian peaks and median notch of the upper lip vermilion." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Absent cupid's bow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Agenesis of cupid's bow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Failure of development of cupid's bow" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33597 ; owl:annotatedTarget "isocyclic compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Lack of cupid's bow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Missing cupid's bow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010800 ; owl:annotatedTarget "Aplasia of cupid's bow" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010801 ; owl:annotatedTarget "Reduced bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion or commissure)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010801 ; owl:annotatedTarget "Flat nasolabial fold" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010801 ; owl:annotatedTarget "Shallow nasolabial fold" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010802 ; owl:annotatedTarget "Increased pigmentation, either focal or generalized, of the skin surrounding the vermilion of the lips." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010802 ; owl:annotatedTarget "Darkening of skin around the mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010802 ; owl:annotatedTarget "Increased pigmentation around the mouth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33598 ; owl:annotatedTarget "carbocyclic compound" . [] oboInOwl:hasDbXref , "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Inner aspect of the upper lip vermilion (normally apposing the teeth) visible in a frontal view, i.e., the presence of an everted upper lip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Eclabium of upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Everted prominent upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Everted upper lip" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33598 ; owl:annotatedTarget "carbocyclic compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Outward turned upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Drooping upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010803 ; owl:annotatedTarget "Protruding upper lip" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010804 ; owl:annotatedTarget "Triangular appearance of the oral aperture with the apex in the midpoint of the upper vermilion and the lower vermilion forming the base." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010804 ; owl:annotatedTarget "Tented mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010804 ; owl:annotatedTarget "Tented upper lip" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010805 ; owl:annotatedTarget "Oral commissures positioned superior to the midline labial fissure." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010805 ; owl:annotatedTarget "Upturned corners of mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010805 ; owl:annotatedTarget "Upturned mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010805 ; owl:annotatedTarget "Upturned oral commisures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33598 ; owl:annotatedTarget "carbocycle" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Gentle upward curve of the upper lip vermilion such that the center is placed well superior to the commissures." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Carp-like mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Carp-shaped mouth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Fish mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Large, carp-shaped mouth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010806 ; owl:annotatedTarget "Wide, carp-shaped mouth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010807 ; owl:annotatedTarget "Visible space between the dental arches in occlusion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010807 ; owl:annotatedTarget "Absence of overlap of upper and lower teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010807 ; owl:annotatedTarget "Open bite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010807 ; owl:annotatedTarget "Open bite between upper and lower teeth" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Tongue extending beyond the alveolar ridges or teeth at rest." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Lingual prolapse" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Lingual prominence" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33608 ; owl:annotatedTarget "hydrogen compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Lingual protrusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Prolapse of tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Prominent tongue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Protruding tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010808 ; owl:annotatedTarget "Tongue sticking out of mouth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33608 ; owl:annotatedTarget "hydrogen molecular entities" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010809 ; owl:annotatedTarget "Increased width of the uvula (subjective finding)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33635 ; owl:annotatedTarget "polycyclic compounds" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010810 ; owl:annotatedTarget "Increased length of the uvula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0010810 ; owl:annotatedTarget "Hyperplasia of uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010810 ; owl:annotatedTarget "Long palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010810 ; owl:annotatedTarget "Elongated uvula" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33636 ; owl:annotatedTarget "bicyclic compounds" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010811 ; owl:annotatedTarget "Decreased width of the uvula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010811 ; owl:annotatedTarget "Narrow palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010811 ; owl:annotatedTarget "Thin uvula" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33653 ; owl:annotatedTarget "aliphatic compounds" . [] oboInOwl:hasDbXref "PMID:19125428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010812 ; owl:annotatedTarget "Decreased length of the uvula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010812 ; owl:annotatedTarget "Short palatine uvula" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010812 ; owl:annotatedTarget "Blunt uvula" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33655 ; owl:annotatedTarget "aromatic compounds" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "More than two clockwise hair whorls." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Abnormal number of hair swirls" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Abnormal number of hair whorls" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Double crown (hair whorls)" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Extra hair swirls" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Extra hair whorl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Supernumary hair swirls" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010813 ; owl:annotatedTarget "Supernumary hair whorl" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33655 ; owl:annotatedTarget "aromatic molecular entity" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010814 ; owl:annotatedTarget "Hair growth from a single point on the scalp in any location other than lateral to the midline and close to the vertex of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010814 ; owl:annotatedTarget "Abnormal location of hair swirl" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010814 ; owl:annotatedTarget "Abnormal position of hair whorl" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010815 ; owl:annotatedTarget "A congenital, hairless plaque consisting of overgrown epidermis, sebaceous glands, hair follicles, apocrine glands and connective tissue. They are a variant of epidermal naevi. Sebaceous naevi most often appear on the scalp, but they may also arise on the face, neck or forehead. At birth, a sevaceous nevus typically appears as a solitary, smooth, yellow-orange hairless patch. Sebaceous naevi become more pronounced around adolescence, often appearing bumpy, warty or scaly." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33655 ; owl:annotatedTarget "aromatics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010815 ; owl:annotatedTarget "Sebaceous mole" . [] oboInOwl:hasDbXref , "PMID:20542174" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010816 ; owl:annotatedTarget "Epidermal naevi are due to an overgrowth of the epidermis and may be present at birth (50%) or develop during childhood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010817 ; owl:annotatedTarget "A type of nevus sebaceous with a linear form, raised borders and yellowish color." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:jalbers", "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010818 ; owl:annotatedTarget "A generalized tonic seizure is a type of generalized motor seizure characterised by bilateral limb stiffening or elevation, often with neck stiffening without a subsequent clonic phase. The tonic activity can be a sustained abnormal posture, either in extension or flexion, sometimes accompanied by tremor of the extremities." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010818 ; owl:annotatedTarget "Generalised tonic seizure" . [] oboInOwl:hasSynonymType hp:plural_form, hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010818 ; owl:annotatedTarget "Generalised tonic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010818 ; owl:annotatedTarget "Generalized tonic seizures" . [] oboInOwl:hasDbXref , , "HPO_CONTRIBUTOR:jalbers", "PMID:11580774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Atonic seizure is a type of motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1 to 2 seconds, involving head, trunk, jaw, or limb musculature." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Astatic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Atonic seizures" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33655 ; owl:annotatedTarget "aromatische Verbindungen" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Drop seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Hypotonic seizures" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010819 ; owl:annotatedTarget "Sudden loss of muscle tone" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:993803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010820 ; owl:annotatedTarget "Focal emotional seizure with crying (dacrystic) is characterized by the presence of stereotyped crying, this may be accompanied by lacrimation, sad facial expression and sobbing. The subjective emotion of sadness may or may not be present." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010820 ; owl:annotatedTarget "Dacrystic seizures" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010821 ; owl:annotatedTarget "Focal emotional seizure with laughing (gelastic) is characterized by bursts of laughter or giggling, usually without appropriate related emotion of happiness, and described as 'mirthless'." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010821 ; owl:annotatedTarget "Gelastic seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010822 ; owl:annotatedTarget "A scintillating scotoma is a common visual aura that can preced a migraine, whereby a spot of flickering light near the center of the visual fields occurs. The spot prevents vision, and is thus termed scotoma. The scotoma can extend into one or more shimmering arcs of white or colored flashing lights." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010823 ; owl:annotatedTarget "An overlap of the bony plates of the skull in an infant, with or without early closure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010823 ; owl:annotatedTarget "Cranial suture ridges" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33658 ; owl:annotatedTarget "arene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010824 ; owl:annotatedTarget "Any structural abnormality of the fifth cranial nerve." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33658 ; owl:annotatedTarget "arenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010825 ; owl:annotatedTarget "Abnormality of the eleventh cranial nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010825 ; owl:annotatedTarget "Abnormality of cranial nerve XI" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33658 ; owl:annotatedTarget "aromatic hydrocarbons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010826 ; owl:annotatedTarget "Abnormality of the twelfth cranial nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010826 ; owl:annotatedTarget "Abnormality of cranial nerve 12" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010826 ; owl:annotatedTarget "Abnormality of cranial nerve xii" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33659 ; owl:annotatedTarget "organic aromatic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010827 ; owl:annotatedTarget "Abnormality of the seventh cranial nerve sometimes also referred to as the facial nerve." . [] oboInOwl:hasDbXref , "PMID:12145388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010828 ; owl:annotatedTarget "Intermittent clonic or tonic contraction of muscles supplied by facial nerve. Muscles are relaxed in between contractions." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010828 ; owl:annotatedTarget "Spasms on one side of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010828 ; owl:annotatedTarget "Hemifacial spasms" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010829 ; owl:annotatedTarget "A reduced ability to discriminate between different temperatures." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010829 ; owl:annotatedTarget "Abnormality of temperature sensation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33661 ; owl:annotatedTarget "monocyclic compounds" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010829 ; owl:annotatedTarget "Impaired temperature sensation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010829 ; owl:annotatedTarget "Loss of temperature sensation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010830 ; owl:annotatedTarget "A reduced sense of touch (tactile sensation). This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010830 ; owl:annotatedTarget "Impaired touch sensation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33662 ; owl:annotatedTarget "annulene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010831 ; owl:annotatedTarget "A loss or impairment of the sensation of the relative position of parts of the body and joint position." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010832 ; owl:annotatedTarget "Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010833 ; owl:annotatedTarget "Spontaneous pain is a kind of neuropathic pain which occurs without an identifiable trigger." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010834 ; owl:annotatedTarget "Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010835 ; owl:annotatedTarget "A pattern of sensory loss with selective loss of touch sensation and proprioception without loss of pain and temperature, or vice-versa." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33662 ; owl:annotatedTarget "annulenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010836 ; owl:annotatedTarget "An abnormal concentration of copper." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010836 ; owl:annotatedTarget "Abnormal copper levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33663 ; owl:annotatedTarget "cyclic hydrocarbon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33663 ; owl:annotatedTarget "cyclic hydrocarbons" . [] oboInOwl:hasDbXref , "PMID:32119309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010837 ; owl:annotatedTarget "Decreased concentration of ceruloplasmin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010837 ; owl:annotatedTarget "Decreased serum ceruloplasmin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010837 ; owl:annotatedTarget "Hypoceruloplasminaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010838 ; owl:annotatedTarget "An increased concentration of non ceruloplasmin bound copper in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33664 ; owl:annotatedTarget "monocyclic hydrocarbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010839 ; owl:annotatedTarget "An increased concentration of copper in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010839 ; owl:annotatedTarget "Increased urinary copper concentration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010841 ; owl:annotatedTarget "An abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG) and being identified at multiple locations (foci)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010843 ; owl:annotatedTarget "Focal (localized) slow activity reflects focal dysfunction, not diffuse dysfunction (i.e., encephalopathy)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010844 ; owl:annotatedTarget "Multifocal slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33664 ; owl:annotatedTarget "monocyclic hydrocarbons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010845 ; owl:annotatedTarget "Diffuse slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010845 ; owl:annotatedTarget "EEG with generalised slow activity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010847 ; owl:annotatedTarget "The presence of complexes of slow spikes and slow waves (<2.5 Hz) in electroencephalography (EEG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010848 ; owl:annotatedTarget "The presence of complexes of spikes and waves (2.5-3.5 Hz) in electroencephalography (EEG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010849 ; owl:annotatedTarget "The presence of complexes of spikes and waves (>3.5 Hz) in electroencephalography (EEG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010850 ; owl:annotatedTarget "Complexes of spikes (<70 ms) and sharp waves (70-200 ms), which are sharp transient waves that have a strong association with epilepsy, in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref , "PMID:22323592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010851 ; owl:annotatedTarget "The burst suppression pattern in electroencephalography refers to a characteristic periodic pattern of low voltage (<10 microvolts) suppressed background and a relatively shorter pattern of higher amplitude slow, sharp, and spiking complexes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010852 ; owl:annotatedTarget "EEG abnormalities (epileptiform discharges) evoked by flashing lights or black and white striped patterns." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010853 ; owl:annotatedTarget "Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010854 ; owl:annotatedTarget "An abnormal generalized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33664 ; owl:annotatedTarget "monocyclic hydrocarbons" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010854 ; owl:annotatedTarget "EEG with generalised low amplitude activity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010855 ; owl:annotatedTarget "An abnormal localized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010855 ; owl:annotatedTarget "EEG with localised low amplitude activity" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010856 ; owl:annotatedTarget "Periodically occurring generalized periodic complexes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010857 ; owl:annotatedTarget "Periodically recurring abnormalities in the EEG." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010858 ; owl:annotatedTarget "Epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010859 ; owl:annotatedTarget "A kind of breech presentation in which the hips are flexed and the knees are extended." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010860 ; owl:annotatedTarget "A kind of breech presentation in which the hips are flexed and the knees are flexed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010861 ; owl:annotatedTarget "A kind of breech presentation in which one or both hips are extended and one or both of the fetus' feet are pointing down and entering the birth canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010862 ; owl:annotatedTarget "A type of motor delay characterized by a delay in acquiring the ability to control the fingers and hands." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33670 ; owl:annotatedTarget "heteromonocyclic compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010863 ; owl:annotatedTarget "A delay in the acquisition of the ability to understand the speech of others." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010864 ; owl:annotatedTarget "Severe mental retardation is defined as an intelligence quotient (IQ) in the range of 20-34." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010864 ; owl:annotatedTarget "Early and severe mental retardation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010864 ; owl:annotatedTarget "Intellectual disability, severe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010864 ; owl:annotatedTarget "Mental retardation, severe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010864 ; owl:annotatedTarget "Severe mental retardation" . [] oboInOwl:hasDbXref , "DSM:313.81" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010865 ; owl:annotatedTarget "An enduring pattern of uncooperative, defiant, and hostile behavior toward authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33670 ; owl:annotatedTarget "heteromonocyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010866 ; owl:annotatedTarget "An incomplete closure of the abdominal wall." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010866 ; owl:annotatedTarget "Abdominal wall defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010867 ; owl:annotatedTarget "A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010868 ; owl:annotatedTarget "A type of dyssynergia affecting eye movements and characterized by the inability to smoothly follow a visual target across the visual field." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010869 ; owl:annotatedTarget "A type of dyssynergy characterized by the lack of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010871 ; owl:annotatedTarget "Incoordination of movement caused by a deficit in the sensory nervous system. Sensory ataxia can be distinguished from cerebellar ataxia by asking the patient to close his or her eyes. Persons with cerebellar ataxia show only a minimal worsening of symptoms, whereas persons with sensory ataxia show a marked worsening of symptoms." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33671 ; owl:annotatedTarget "heteropolycyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010871 ; owl:annotatedTarget "Ataxia, sensory" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010872 ; owl:annotatedTarget "An inversion of the T-wave (which is normally positive)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010873 ; owl:annotatedTarget "Atrophy of the cervical segment of the spinal cord." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010874 ; owl:annotatedTarget "The presence of xanthomas (intra-and extra-cellular accumulations of cholesterol) extensor tendons (typically over knuckles, Achilles tendon, knee, and elbows)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010875 ; owl:annotatedTarget "A diagnostic reflex elicited by stimulation of the skin over the surface of the lateral malleolus of the foot. The Chaddock refelx is present if there is extension of one or more or all of the toes with or without fanning of them when the external inframalleolar skin is stimulated. The Chaddock sign, similar to the Babinski sign, is taken to be an indication of disease of the spinocortical (pyramidal) tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33671 ; owl:annotatedTarget "polyheterocyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010876 ; owl:annotatedTarget "An abnormal level of a circulating protein in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010876 ; owl:annotatedTarget "Blood protein disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010877 ; owl:annotatedTarget "A type of strabismus in which the fixating eye is always the same one, while the other eye is constantly deviated. Monocular strabismus is to be distinguished from alternating strabismus, in which either of the eyes 'squints' at different times." . [] oboInOwl:hasDbXref , "eMedicine:402757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010878 ; owl:annotatedTarget "The presence during the prenatal period of a cystic mass with multiple septa with multiple, asymmetric, thin-walled cysts near the posterior aspect of the neck. Fetal cystic hygroma can be defined as nuchal translucency with or without septations measuring greater than 3.0 mm. Increased NT refers to a measurement above the 95th centile, and the term is used irrespective of whether the collection of fluid is septated or not, and whether it is confined to the neck or envelopes the whole fetus. After 14 weeks, increased NT usually resolves, but in some cases it evolves into nuchal edema or cystic hygromas." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33672 ; owl:annotatedTarget "heterobicyclic compounds" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010878 ; owl:annotatedTarget "Foetal cystic hygroma" . [] oboInOwl:hasDbXref , "PMID:12751779", "PMID:15846173", "PMID:28511453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010880 ; owl:annotatedTarget "Nuchal translucency is the sonographic appearance of subcutaneous accumulation of liquid in the back of the fetal neck in the first trimester of pregnancy (11-14 gestational weeks of pregnancy)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010881 ; owl:annotatedTarget "An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010881 ; owl:annotatedTarget "Umbilical cord issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010882 ; owl:annotatedTarget "A congenital disorder of the pulmonary valve in which the orifice of the valve fails to develop." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33674 ; owl:annotatedTarget "s-block molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010883 ; owl:annotatedTarget "A congenital disorder of the aortic valve in which the orifice of the valve fails to develop." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010884 ; owl:annotatedTarget "Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010885 ; owl:annotatedTarget "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010885 ; owl:annotatedTarget "Death of bone due to decreased blood supply" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33674 ; owl:annotatedTarget "s-block compounds" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010885 ; owl:annotatedTarget "Ischaemic bone necrosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010886 ; owl:annotatedTarget "A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010888 ; owl:annotatedTarget "Morbus Koehler is a Juvenile aseptic necrosis affecting the Os naviculare pedis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010889 ; owl:annotatedTarget "Morbus Kienboeck is a Juvenile aseptic necrosis affecting the Os lunatum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010890 ; owl:annotatedTarget "Morbus Osgood-Schlatter is a Juvenile aseptic necrosis affecting the Tuberositas tibiae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010891 ; owl:annotatedTarget "A developmental growth retardation of the vertebral end plates that may lead to secondary destruction of the vertebral end plates and protrusion of the nucleus pulposus into the vertebral body (so called Schmorl's nodes as seen on x-rays)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33674 ; owl:annotatedTarget "s-block molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010892 ; owl:annotatedTarget "Any deviation from the normal concentration of a branched chain family amino acid in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010893 ; owl:annotatedTarget "Any deviation from the normal concentration of phenylalanine in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010894 ; owl:annotatedTarget "Any deviation from the normal concentration of a serine family amino acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33675 ; owl:annotatedTarget "p-block compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010895 ; owl:annotatedTarget "Any deviation from the normal concentration of glycine in the blood circulation." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "Beilstein:1728920" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33675 ; owl:annotatedTarget "p-block molecular entities" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010896 ; owl:annotatedTarget "An elevated plasma concentration of sarcosine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33675 ; owl:annotatedTarget "p-block molecular entitiy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010896 ; owl:annotatedTarget "High plasma sarcosine levels" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010897 ; owl:annotatedTarget "An elevated urinary concentration of sarcosine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010897 ; owl:annotatedTarget "High urine sarcosine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33676 ; owl:annotatedTarget "d-block molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010898 ; owl:annotatedTarget "An deviation from the normal concentration of sarcosine in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010899 ; owl:annotatedTarget "Any deviation from the normal concentration of an aspartate family amino acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33676 ; owl:annotatedTarget "d-block compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010900 ; owl:annotatedTarget "Any deviation from the normal concentration of threonine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33676 ; owl:annotatedTarget "d-block molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010901 ; owl:annotatedTarget "Any deviation from the normal concentration of methionine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33693 ; owl:annotatedTarget "oxygen hydride" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010902 ; owl:annotatedTarget "Any deviation from the normal concentration of a glutamine family amino acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33693 ; owl:annotatedTarget "hydrides of oxygen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010903 ; owl:annotatedTarget "Any deviation from the normal concentration of glutamine in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010904 ; owl:annotatedTarget "An abnormality of a histidine metabolic process." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33693 ; owl:annotatedTarget "oxygen hydrides" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33694 ; owl:annotatedTarget "biopolymer" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010906 ; owl:annotatedTarget "An increased concentration of histidine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010906 ; owl:annotatedTarget "High blood histidine level" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "CAS:111-02-4" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33694 ; owl:annotatedTarget "Biopolymere" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010907 ; owl:annotatedTarget "Any deviation from the normal concentration of proline or a proline metabolite in the blood circulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010908 ; owl:annotatedTarget "Any deviation from the normal concentration of lysine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33694 ; owl:annotatedTarget "biomacromolecules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010909 ; owl:annotatedTarget "Any deviation from the normal concentration of arginine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33694 ; owl:annotatedTarget "biopolymers" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010910 ; owl:annotatedTarget "An increased concentration of valine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010910 ; owl:annotatedTarget "High blood valine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "genetically encoded biomacromolecules" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "genetically encoded biopolymers" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010911 ; owl:annotatedTarget "An increased concentration of leucine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010911 ; owl:annotatedTarget "High blood leucine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "information biomacromolecules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010912 ; owl:annotatedTarget "Any deviation from the normal concentration of isoleucine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "information biopolymers" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010913 ; owl:annotatedTarget "An increased concentration of isoleucine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010913 ; owl:annotatedTarget "High blood isoleucine concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "information macromolecule" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010914 ; owl:annotatedTarget "Any deviation from the normal circulation of valine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33695 ; owl:annotatedTarget "information macromolecules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010915 ; owl:annotatedTarget "An abnormality of a pyruvate family amino acid metabolic process." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "canonical amino-acid residue" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010916 ; owl:annotatedTarget "An abnormality of an alanine metabolic process." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "CAS:111-02-4" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "canonical amino-acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010917 ; owl:annotatedTarget "Any deviation from the normal concentration of tyrosine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "common amino acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010918 ; owl:annotatedTarget "An abnormality of a cysteine metabolic process." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010919 ; owl:annotatedTarget "An abnormality of a homocysteine metabolic process." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "proteinogenic amino-acid residues" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:vkumar", "PMID:18035564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010920 ; owl:annotatedTarget "Zonular cataracts are defined to be cataracts that affect specific regions of the lens." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:vkumar" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010921 ; owl:annotatedTarget "A 'coral-like' pattern of opacity in the lens of the eye. That is, a cataract with an irregular, stellate form." . [] oboInOwl:hasDbXref , "PMID:17539799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010922 ; owl:annotatedTarget "A form of cataract in which the lens substance has shrunk, leaving a collapsed, flattened capsule with little or no cortex or epithelium on the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010923 ; owl:annotatedTarget "A type of cataract affecting the anterior pole of lens immediately adjacent to ('beneath') the lens capsule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010924 ; owl:annotatedTarget "A cataract that affects the posterior part of the cortex of the lens." . [] oboInOwl:hasDbXref , "PMID:10521291", "PMID:9718335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010926 ; owl:annotatedTarget "A kind of nuclear cataract characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "standard amino acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010927 ; owl:annotatedTarget "An abnormality of divalent inorganic cation homeostasis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33700 ; owl:annotatedTarget "standard amino-acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010929 ; owl:annotatedTarget "An abnormality of cation homeostasis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010930 ; owl:annotatedTarget "An abnormality of monovalent inorganic cation homeostasis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33702 ; owl:annotatedTarget "polyatomic cations" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33703 ; owl:annotatedTarget "amino-acid cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010931 ; owl:annotatedTarget "An abnormal concentration of sodium." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010931 ; owl:annotatedTarget "Abnormal blood Na+ levels" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010931 ; owl:annotatedTarget "Abnormal circulating Na concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33703 ; owl:annotatedTarget "amino acid cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010932 ; owl:annotatedTarget "An abnormality of a nucleobase metabolic process." . [] oboInOwl:hasDbXref , "PMID:9153281" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010933 ; owl:annotatedTarget "An increased level of xanthine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33703 ; owl:annotatedTarget "amino-acid cations" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010934 ; owl:annotatedTarget "An increased concentration of xanthine in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010935 ; owl:annotatedTarget "An abnormality of the upper urinary tract." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "CAS:111-02-4" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010935 ; owl:annotatedTarget "Abnormality of the upper urinary tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010936 ; owl:annotatedTarget "An abnormality of the lower urinary tract." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "alpha-amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "An abnormality of the nasal skeleton." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Abnormality of the nasal skeleton" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Anomaly of the nasal skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Deformity of the bones of the nose" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "Amino acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Deformity of the nasal skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Distortion of the bones of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Distortion of the nasal skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Malformation of the bones of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010937 ; owl:annotatedTarget "Malformation of the nasal skeleton" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "Amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010938 ; owl:annotatedTarget "An abnormality of the external nose." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010938 ; owl:annotatedTarget "Abnormality of the external nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010938 ; owl:annotatedTarget "Anomaly of the external nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010938 ; owl:annotatedTarget "Deformity of the external nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010938 ; owl:annotatedTarget "Malformation of the external nose" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "alpha-amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010939 ; owl:annotatedTarget "An abnormality of the nasal bone, comprising the left nasal bone and the right nasal bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010939 ; owl:annotatedTarget "Abnormality of the nasal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010939 ; owl:annotatedTarget "Anomaly of the nasal bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010939 ; owl:annotatedTarget "Deformity of the nasal bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010939 ; owl:annotatedTarget "Malformation of the nasal bones" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "alpha-amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010940 ; owl:annotatedTarget "Absence or underdevelopment of the nasal bone." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33704 ; owl:annotatedTarget "alpha-amino carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Absence of the nasal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Failure of development of the nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Lack of development of the nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Absence of the nasal bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Agenesis of the nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0010941 ; owl:annotatedTarget "Missing nasal bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33706 ; owl:annotatedTarget "beta-amino acid" . [] oboInOwl:hasDbXref , "PMID:16100637", "PMID:9527573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010942 ; owl:annotatedTarget "A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart." . [] oboInOwl:hasDbXref , "PMID:16100637", "PMID:20175047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010943 ; owl:annotatedTarget "Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010943 ; owl:annotatedTarget "Echogenic foetal bowel" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33706 ; owl:annotatedTarget "beta-amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010944 ; owl:annotatedTarget "An abnormality of the renal pelvis." . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010945 ; owl:annotatedTarget "Mild pyelectasis is defined as a hypoechoic spherical or elliptical space within the renal pelvis that measures at least 5mm and not more than 10 mm. The measurement is taken on a transverse section through the fetal renal pelvis using the maximum anterior-to-posterior measurement." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010945 ; owl:annotatedTarget "Foetal pyelectasis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010945 ; owl:annotatedTarget "Foetal renal pelvic dilatation" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010945 ; owl:annotatedTarget "Mild foetal hydronephrosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010946 ; owl:annotatedTarget "The presence of dilatation of the renal pelvis." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR0106010002" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33707 ; owl:annotatedTarget "gamma-amino acid" . [] oboInOwl:hasDbXref , "PMID:16449256", "PMID:21048453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010947 ; owl:annotatedTarget "A first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010948 ; owl:annotatedTarget "A structural abnormality of the fetal circulation system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010948 ; owl:annotatedTarget "Abnormality of the foetal cardiovascular system" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010948 ; owl:annotatedTarget "Abnormality of the foetal circulation system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010949 ; owl:annotatedTarget "A first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33707 ; owl:annotatedTarget "gamma-amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010950 ; owl:annotatedTarget "An abnormality of the fourth ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010951 ; owl:annotatedTarget "An abnormality of the third ventricle." . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010952 ; owl:annotatedTarget "A kind of ventriculomegaly occurring in the fetal period and usually diagnosed by prenatal ultrasound. Cerebral ventriculomegaly is defined by atrial measurements 10 mm or more. Mild ventriculomegaly (MVM) is defined as measurements between 10 and 15 mm. Measurements are obtained from an axial plane at the level of the thalamic nuclei just below the standard image to measure the BPD (PMID:16100637)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010952 ; owl:annotatedTarget "Mild foetal ventriculomegaly" . [] oboInOwl:hasDbXref , "eMedicine:1135286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010953 ; owl:annotatedTarget "A form of hydrocephalus in which the flow of cerebrospinal fluid (CSF) within the cerebral ventricular system or in the outlets of the CSF to the arachnoid space is obstructed." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33708 ; owl:annotatedTarget "amino-acid residue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010954 ; owl:annotatedTarget "Underdevelopment of the right-sided structures of the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010954 ; owl:annotatedTarget "Hypoplastic right heart syndrome" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010954 ; owl:annotatedTarget "Underdeveloped right heart" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33708 ; owl:annotatedTarget "amino acid residue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010955 ; owl:annotatedTarget "The presence of a dilated urinary bladder." . [] oboInOwl:hasDbXref , "PMID:20837325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010956 ; owl:annotatedTarget "Fetal megacystis is an abnormally enlarged bladder identified at any gestational age." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010956 ; owl:annotatedTarget "Foetal megacystis" . [] oboInOwl:hasDbXref , "eMedicine:1016086" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010957 ; owl:annotatedTarget "A developmental defect resulting in an obstructing membrane in the posterior male urethra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0010957 ; owl:annotatedTarget "Posterior urethral valves" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33708 ; owl:annotatedTarget "amino-acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010958 ; owl:annotatedTarget "A bilateral form of agenesis of the kidney." . [] oboInOwl:hasDbXref , "PMID:28638495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010959 ; owl:annotatedTarget "Congenital pulmonary airway malformation (CPAM) - previously known as congenital cystic adenomatoid malformation (CCAM) - is a relatively rare developmental malformation of the lower respiratory tract. It is a hamartomatous, dysplastic developmental abnormality of the lung characterized by abnormal airway patterning during lung branching morphogenesis and is formed by abnormal branching of the immature bronchioles." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010959 ; owl:annotatedTarget "CCAM" . [] oboInOwl:hasDbXref , "PMID:20610189" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010960 ; owl:annotatedTarget "The presence of microscopic cystic masses of nonfunctioning pulmonary tissue that lack an obvious communication with the tracheobronchial tree." . [] oboInOwl:hasDbXref , "PMID:20610189" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010961 ; owl:annotatedTarget "A kind of bronchopulmonary sequestration that is incorporated into the normal surrounding lung." . [] oboInOwl:hasDbXref , "PMID:20610189" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010962 ; owl:annotatedTarget "A kind of bronchopulmonary sequestration that is completely discrete from the normal lung and is surrounded by separate pleura." . [] oboInOwl:hasDbXref , "PMID:20538709" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010963 ; owl:annotatedTarget "By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010963 ; owl:annotatedTarget "Absence of stomach bubble on foetal sonography" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010963 ; owl:annotatedTarget "Non-visualisation of the foetal stomach" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33709 ; owl:annotatedTarget "Aminocarbonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010964 ; owl:annotatedTarget "Any deviation from the normal concentration of a long-chain fatty acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33709 ; owl:annotatedTarget "Aminokarbonsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010965 ; owl:annotatedTarget "Any deviation from the normal concentration of phytanic acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33709 ; owl:annotatedTarget "Aminosaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010966 ; owl:annotatedTarget "Any deviation from the normal concentration of a fatty acid anion in the blood circulation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:16341241" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33709 ; owl:annotatedTarget "amino acids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010967 ; owl:annotatedTarget "Any deviation from the normal concentration of carnitine in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010968 ; owl:annotatedTarget "An abnormality of liposaccharide metabolism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010969 ; owl:annotatedTarget "An abnormality of glycolipid metabolism." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33710 ; owl:annotatedTarget "alpha-amino-acid residues" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010970 ; owl:annotatedTarget "An abnormality of an erythrocyte cell surface molecule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010971 ; owl:annotatedTarget "Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010972 ; owl:annotatedTarget "A kind of anemia characterized by inadequate production of erythrocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33719 ; owl:annotatedTarget "alpha-amino-acid cation" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010972 ; owl:annotatedTarget "Anaemia of inadequate production" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010972 ; owl:annotatedTarget "Dyserythropoietic anaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010974 ; owl:annotatedTarget "An abnormality of myeloid leukocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33719 ; owl:annotatedTarget "alpha-amino acid cations" . [] oboInOwl:hasDbXref , "MP:0002458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010975 ; owl:annotatedTarget "A deviation from the normal count of B cells, i.e., the cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010975 ; owl:annotatedTarget "Abnormal number of B cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010975 ; owl:annotatedTarget "Abnormal numbers of B cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33719 ; owl:annotatedTarget "alpha-amino-acid cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010976 ; owl:annotatedTarget "An abnormal decrease from the normal count of B cells." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010976 ; owl:annotatedTarget "Low B cell count" . [] oboInOwl:hasDbXref , "PMID:28691037" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010977 ; owl:annotatedTarget "An abnormal functioning of phagocytosis. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33720 ; owl:annotatedTarget "carbohydrate acid" . [] oboInOwl:hasDbXref , "MP:0001790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010978 ; owl:annotatedTarget "A functional abnormality of the immune system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33720 ; owl:annotatedTarget "carbohydrate acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010979 ; owl:annotatedTarget "An abnormal increase or decrease in the level of lipoprotein cholesterol in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010980 ; owl:annotatedTarget "An abnormal increase in the level of lipoprotein cholesterol in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:23625688" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33721 ; owl:annotatedTarget "carbohydrate acid anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33721 ; owl:annotatedTarget "carbohydrate acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010981 ; owl:annotatedTarget "Lack of fat in blood" . [] oboInOwl:hasDbXref , "ISBN:978-0192628961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010982 ; owl:annotatedTarget "A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases." . [] oboInOwl:hasDbXref , "ISBN:978-0192628961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010983 ; owl:annotatedTarget "A type of multifactorial inheritance governed by the simultaneous action of a few gene loci. It is recommended this term be used for traits governed by three loci, although it is noted that usage of this term in the literature is not uniform." . [] oboInOwl:hasDbXref , "ISBN:978-0192628961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010984 ; owl:annotatedTarget "A type of multifactorial inheritance governed by the simultaneous action of two gene loci." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010987 ; owl:annotatedTarget "An abnormality of the morphology or counts of the cells that make up the immune system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33729 ; owl:annotatedTarget "tetritol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010988 ; owl:annotatedTarget "An abnormality of the extrinsic pathway (also known as the tissue factor pathway) of the coagulation cascade." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33729 ; owl:annotatedTarget "tetritols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010989 ; owl:annotatedTarget "An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010990 ; owl:annotatedTarget "An abnormality of blood coagulation, common pathway." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010991 ; owl:annotatedTarget "An abnormality of the abdominal musculature." . [] oboInOwl:hasDbXref , "PMID:12559262" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010992 ; owl:annotatedTarget "Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33744 ; owl:annotatedTarget "iron group molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010993 ; owl:annotatedTarget "An abnormality of the cerebral subcortex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33744 ; owl:annotatedTarget "iron group molecular entities" . [] oboInOwl:hasDbXref , "PMID:21469956" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010994 ; owl:annotatedTarget "Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010994 ; owl:annotatedTarget "Abnormality of the neostriatum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010994 ; owl:annotatedTarget "Abnormality of the striate nucleus" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33752 ; owl:annotatedTarget "hexonic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010995 ; owl:annotatedTarget "Any deviation from the normal concentration of a dicarboxylic acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33752 ; owl:annotatedTarget "aldohexonic acids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:gcarletti" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010996 ; owl:annotatedTarget "Any deviation from the normal concentration of a monocarboxylic acid in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:16814619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010997 ; owl:annotatedTarget "Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with ionizing radiation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010997 ; owl:annotatedTarget "Chromosomal breakage induced by ionising radiation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0010998 ; owl:annotatedTarget "An increase in the number of spontaneous sister chromatid exchanges observed in cell culture of lymphocytes or other cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33752 ; owl:annotatedTarget "hexonic acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0010999 ; owl:annotatedTarget "Absent optic tract" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:24362891" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33760 ; owl:annotatedTarget "hexonate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011000 ; owl:annotatedTarget "Absent/small optic tract" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011000 ; owl:annotatedTarget "Absent/underdeveloped optic tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011001 ; owl:annotatedTarget "An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often referred to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33760 ; owl:annotatedTarget "aldohexonates" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011001 ; owl:annotatedTarget "Increased bone density" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011001 ; owl:annotatedTarget "Increased bone mineral density" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33760 ; owl:annotatedTarget "hexonates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011002 ; owl:annotatedTarget "Abnormally increased formation of dense trabecular bone tissue. Despite the increased density of bone tissue, osteopetrotic bones tend to be more fracture-prone than normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011002 ; owl:annotatedTarget "Harder, denser, fracture-prone bones" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011003 ; owl:annotatedTarget "A severe form of myopia with greater than -6.00 diopters." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011003 ; owl:annotatedTarget "Severe near sightedness" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011003 ; owl:annotatedTarget "Severely close sighted" . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011003 ; owl:annotatedTarget "Severely near sighted" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011004 ; owl:annotatedTarget "An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011005 ; owl:annotatedTarget "A type of cirrhosis characterized by the presence of regenerative nodules of a variety of sizes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33767 ; owl:annotatedTarget "cobalt group molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011006 ; owl:annotatedTarget "An abnormality of the neck musculature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011006 ; owl:annotatedTarget "Abnormality of cervical musculature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011006 ; owl:annotatedTarget "Abnormality of the musculature of the neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011006 ; owl:annotatedTarget "Neck muscle issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011008 ; owl:annotatedTarget "The speed at which disease manifestations appear and develop." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011009 ; owl:annotatedTarget "Sudden appearance of disease manifestations over a short period of time." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011010 ; owl:annotatedTarget "Slow, creeping onset, slow progress and long continuance of disease manifestations." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33767 ; owl:annotatedTarget "cobalt group molecular entities" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011010 ; owl:annotatedTarget "Chronic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011011 ; owl:annotatedTarget "Somewhat rapid onset and change of disease manifestations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011012 ; owl:annotatedTarget "A deviation from the normal concentration of a polysaccharide in the blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33822 ; owl:annotatedTarget "hydroxy compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011013 ; owl:annotatedTarget "A deviation from the normal concentration of a carbohydrate in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33822 ; owl:annotatedTarget "organic alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011014 ; owl:annotatedTarget "Abnormality of glucose homeostasis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33822 ; owl:annotatedTarget "organic hydroxy compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011015 ; owl:annotatedTarget "An abnormality of the concentration of glucose in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33832 ; owl:annotatedTarget "organic cyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011017 ; owl:annotatedTarget "An abnormality in a cellular process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:25286851" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33833 ; owl:annotatedTarget "heteroarenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011018 ; owl:annotatedTarget "An abnormality of the cell cycle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011018 ; owl:annotatedTarget "Abnormality of the cell cycle" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33833 ; owl:annotatedTarget "hetarenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011019 ; owl:annotatedTarget "An abnormality of chromosome condensation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33836 ; owl:annotatedTarget "benzenoid aromatic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011020 ; owl:annotatedTarget "An abnormality of the metabolism of mucopolysaccharide." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011022 ; owl:annotatedTarget "A deviation from the normal concentration of an unsaturated fatty acid in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33836 ; owl:annotatedTarget "benzenoid compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011023 ; owl:annotatedTarget "Any deviation from the normal concentration of a prostaglandin in the blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33837 ; owl:annotatedTarget "conjugated proteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011024 ; owl:annotatedTarget "An abnormality of the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011024 ; owl:annotatedTarget "Abnormality of the GI tract" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011024 ; owl:annotatedTarget "Abnormality of the gastrointestinal tract" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011024 ; owl:annotatedTarget "Digestive system disease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011024 ; owl:annotatedTarget "Gastrointestinal disease" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33837 ; owl:annotatedTarget "complex protein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011025 ; owl:annotatedTarget "Abnormal functionality of the cardiovascular system." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33839 ; owl:annotatedTarget "macromolecule" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011026 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the vagina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011026 ; owl:annotatedTarget "Absent/small vagina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011026 ; owl:annotatedTarget "Absent/underdeveloped vagina" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33839 ; owl:annotatedTarget "macromolecules" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011027 ; owl:annotatedTarget "An abnormality of the fallopian tube." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33839 ; owl:annotatedTarget "polymer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011028 ; owl:annotatedTarget "An abnormality of blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33839 ; owl:annotatedTarget "polymer molecule" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011029 ; owl:annotatedTarget "The presence of hemorrhage within the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011029 ; owl:annotatedTarget "Internal bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011029 ; owl:annotatedTarget "Internal haemorrhage" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:25286853" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33839 ; owl:annotatedTarget "polymers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011030 ; owl:annotatedTarget "An abnormality of the homeostasis (concentration) of transition element cation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33842 ; owl:annotatedTarget "aromatic annulenes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33847 ; owl:annotatedTarget "monocyclic arenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011031 ; owl:annotatedTarget "An abnormality of the homeostasis (concentration) of iron cation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011032 ; owl:annotatedTarget "An abnormality of the regulation of body fluids." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011032 ; owl:annotatedTarget "Abnormality of fluid regulation" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33853 ; owl:annotatedTarget "phenols" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011032 ; owl:annotatedTarget "Fluid imbalance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011033 ; owl:annotatedTarget "An impairment of a fructose metabolic process." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33853 ; owl:annotatedTarget "Aryl alcohol" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33853 ; owl:annotatedTarget "a phenol" . [] oboInOwl:hasDbXref , "PMID:21039326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011034 ; owl:annotatedTarget "The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011034 ; owl:annotatedTarget "Amyloid disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011035 ; owl:annotatedTarget "An abnormality of the cortex of the kidney." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33853 ; owl:annotatedTarget "arenols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011036 ; owl:annotatedTarget "An altered ability of the kidneys to void urine and/or specific substances." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011037 ; owl:annotatedTarget "A decreased rate of urine production." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011038 ; owl:annotatedTarget "An abnormality of renal absorption." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33856 ; owl:annotatedTarget "Aromatic amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011039 ; owl:annotatedTarget "An abnormality of the helix. The helix is the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011040 ; owl:annotatedTarget "An abnormality of the intrahepatic bile duct." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "PMID:25987292" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33856 ; owl:annotatedTarget "aromatic amino acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011041 ; owl:annotatedTarget "Aplasia or developmental hypoplasia of the cervical vertebral column." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011041 ; owl:annotatedTarget "Absent/small cervical spine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011041 ; owl:annotatedTarget "Absent/underdeveloped cervical spine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33859 ; owl:annotatedTarget "aromatic carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011042 ; owl:annotatedTarget "An abnormal concentration of potassium." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011042 ; owl:annotatedTarget "Abnormal blood K concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33861 ; owl:annotatedTarget "transition element coordination entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011043 ; owl:annotatedTarget "An abnormal concentration of corticotropin in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011043 ; owl:annotatedTarget "Abnormality of circulating ACTH level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33861 ; owl:annotatedTarget "transition metal coordination compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011044 ; owl:annotatedTarget "The presence of an altered number of of permanent teeth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011044 ; owl:annotatedTarget "Abnormal complement of permanent teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011044 ; owl:annotatedTarget "Abnormal number of adult teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011044 ; owl:annotatedTarget "Abnormal number of permanent teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011044 ; owl:annotatedTarget "Abnormal permanent tooth count" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33861 ; owl:annotatedTarget "transition metal coordination entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Agenesis of upper secondary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Agenesis of adult maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Failure of development of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Absence of permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Absence of permanent upper central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Absence of permanent upper front tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Missing adult upper central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Missing permanent maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Missing permanent upper central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011045 ; owl:annotatedTarget "Missing permanent upper front tooth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33888 ; owl:annotatedTarget "cobalt molecular entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Agenesis of upper central primary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Agenesis of deciduous maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Failure of development of deciduous maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Failure of development of primary maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Absence of deciduous maxillary central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Absence of primary maxillary central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Absence of upper front baby tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Missing deciduous maxillary central incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33888 ; owl:annotatedTarget "cobalt compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Missing primary maxillary central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Missing upper front baby tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011046 ; owl:annotatedTarget "Missing upper front milk tooth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33888 ; owl:annotatedTarget "cobalt molecular entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Agenesis of lower primary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Agenesis of deciduous lower central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Agenesis of primary lower central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Failure of development of deciduous mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Failure of development of primary mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Absence of deciduous mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Absence of primary mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing deciduous mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing lower central incisor milk tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing lower front baby tooth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33890 ; owl:annotatedTarget "cobalt coordination entity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing lower front milk tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing lower front primary tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011047 ; owl:annotatedTarget "Missing primary mandibular central incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33890 ; owl:annotatedTarget "cobalt coordination compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Agenesis of lower secondary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Agenesis of adult mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Failure of development of permanent mandibular central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Absence of permanent lower central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Absence of permanent lower front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Absence of permanent mandibular central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Missing adult lower central incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Missing permanent lower central incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Missing permanent lower front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011048 ; owl:annotatedTarget "Missing permanent mandibular central incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33890 ; owl:annotatedTarget "cobalt coordination entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Agenesis of deciduous maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Failure of development of deciduous maxillary lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33892 ; owl:annotatedTarget "iron coordination entity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Failure of development of primary maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Absence of deciduous maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Absence of primary maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Missing deciduous maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011049 ; owl:annotatedTarget "Missing primary maxillary lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33892 ; owl:annotatedTarget "iron coordination compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Agenesis of one or more upper lateral secondary incisor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Agenesis of permanent upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Failure of development of permanent maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Failure of development of permanent upper lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Absence of permanent maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Missing permanent maxillary lateral incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011050 ; owl:annotatedTarget "Missing permanent upper lateral incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33892 ; owl:annotatedTarget "iron coordination entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Agenesis of premolar tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Agenesis of bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Failure of development of bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Failure of development of premolar" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33893 ; owl:annotatedTarget "reagent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Absence of bicuspid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Absence of premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Missing bicuspid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011051 ; owl:annotatedTarget "Missing premolar" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33893 ; owl:annotatedTarget "reactif" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Agenesis of maxillary premolar." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Agenesis of maxillary bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Failure of development of maxillary bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Failure of development of maxillary premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Absence of maxillary bicuspid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Absence of maxillary premolar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Absence of upper premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Missing maxillary premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Missing upper bicuspid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33893 ; owl:annotatedTarget "reactivo" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011052 ; owl:annotatedTarget "Missing upper premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Agenesis of mandibular premolar." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Failure of development of mandibular premolar" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33893 ; owl:annotatedTarget "reagents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Absence of lower premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Absence of mandibular premolar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Missing lower premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011053 ; owl:annotatedTarget "Missing mandibular premolar" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "Squalene" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33906 ; owl:annotatedTarget "cobalt corrinoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011054 ; owl:annotatedTarget "Agenesis of molar tooth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011054 ; owl:annotatedTarget "Absent molars" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011054 ; owl:annotatedTarget "Failure of development of molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011054 ; owl:annotatedTarget "Absence of molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011054 ; owl:annotatedTarget "Missing molar" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33906 ; owl:annotatedTarget "cobalt-corrinoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Agenesis of secondary molar tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Agenesis of secondary molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Failure of development of permanent molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Failure of development of secondary molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Absence of adult molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Absence of permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Missing adult molar" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33909 ; owl:annotatedTarget "metal-tetrapyrrole" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011055 ; owl:annotatedTarget "Missing permanent molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Agenesis of either maxillary first permanent molar or mandibular first permanent molar or both." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Agenesis of six year molar" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33909 ; owl:annotatedTarget "metal-tetrapyrrole complex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Failure of development of first permanent molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Failure of development of six year molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Absence of first permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Absence of six year molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Missing first permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011056 ; owl:annotatedTarget "Missing six year molar" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33909 ; owl:annotatedTarget "metallotetrapyrroles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Agenesis of either mandibular second permanent molar or maxillary second permanent molar." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Agenesis of twelve year molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Failure of development of second permanent molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Failure of development of twelve year molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Absence of second permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Absence of twelve year molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Missing second permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011057 ; owl:annotatedTarget "Missing twelve year molar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "A generalized form of periodontitis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Generalised gum disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Generalized gum disease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Widespread gum disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Generalised periodontal disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Generalised periodontitis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011058 ; owl:annotatedTarget "Generalized periodontal disease" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "Corrinoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "A localized form of periodontitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Limited area of gum disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Localised gum disease" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Localized gum disease" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Localised periodontal disease" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "corrinoid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Localised periodontitis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011059 ; owl:annotatedTarget "Localized periodontal disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011060 ; owl:annotatedTarget "Developmental dysplasia of dentin affecting only the primary dentition." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011060 ; owl:annotatedTarget "Dentinogenesis imperfecta of baby teeth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "corrinoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011061 ; owl:annotatedTarget "An abnormality of the structure or composition of the teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011061 ; owl:annotatedTarget "Abnormality of tooth part" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011061 ; owl:annotatedTarget "Abnormality of tooth structure" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "Corrinoid protein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Misaligned incisor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Abnormality of position of incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Malposition of incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Abnormality of alignment of incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Crooked front teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Crooked incisors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011062 ; owl:annotatedTarget "Misalignment of incisors" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "squalene" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "Corrinoid protein Co+" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011063 ; owl:annotatedTarget "An abnormality of morphology of the incisor tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011063 ; owl:annotatedTarget "Abnormality of shape of incisor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "Korrinoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011064 ; owl:annotatedTarget "The presence of an altered number of the incisor teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011064 ; owl:annotatedTarget "Abnormal number of front teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011064 ; owl:annotatedTarget "Abnormal number of incisors" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "corrinoide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011065 ; owl:annotatedTarget "An abnormal conical morphology of the incisor tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011065 ; owl:annotatedTarget "Cone shaped front tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011065 ; owl:annotatedTarget "Shark tooth incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011065 ; owl:annotatedTarget "Peg shaped front tooth" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33913 ; owl:annotatedTarget "corrinoides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011065 ; owl:annotatedTarget "Pointed front tooth" . [] oboInOwl:hasDbXref , "PMID:18262485", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "A supernumerary tooth in the midline between the maxillary central incisors." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "Extra tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "Extra tooth in the midline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "Median supernumary tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "Midline supernumary tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011067 ; owl:annotatedTarget "Mesiodentes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33916 ; owl:annotatedTarget "PMID:10723607" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011068 ; owl:annotatedTarget "The presence of an odontoma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011068 ; owl:annotatedTarget "Odontomas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33916 ; owl:annotatedTarget "aldopentose" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "The presence of one or more teeth additional to the normal number." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Extra teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Hyperdontia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Increased number of teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Increased tooth count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Supplemental dentition" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Supplemental teeth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33916 ; owl:annotatedTarget "aldopentoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Supernumary dentition" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "Supernumary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011069 ; owl:annotatedTarget "More teeth than normal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33917 ; owl:annotatedTarget "aldohexose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011070 ; owl:annotatedTarget "An abnormality of morphology of molar tooth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011070 ; owl:annotatedTarget "Abnormal shape of molar tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011071 ; owl:annotatedTarget "An abnormality of morphology of permanent molar." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33917 ; owl:annotatedTarget "aldohexoses" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011071 ; owl:annotatedTarget "Abnormality of shape of adult molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011071 ; owl:annotatedTarget "Abnormality of shape of permanent molar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Absence of tooth root" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33937 ; owl:annotatedTarget "macronutrients" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Agenesis of tooth root" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Aplasia of tooth root" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Missing tooth root" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Rootless teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Teeth without roots" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011072 ; owl:annotatedTarget "Tooth with dentin dysplasia type i" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33942 ; owl:annotatedTarget "ribo-pentose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "A developmental defect of tooth color." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of dental color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of dental colour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of dental shade" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of tooth color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of tooth colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011073 ; owl:annotatedTarget "Abnormality of tooth shade" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33942 ; owl:annotatedTarget "ribose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "A localized form of developmental hypoplasia of the dental enamel." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33942 ; owl:annotatedTarget "Rib" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "Localised hypoplasia of dental enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "Localised hypoplasia of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "Localized hypoplasia of tooth enamel" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "Localised dysplasia of tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011074 ; owl:annotatedTarget "Localized dysplasia of tooth enamel" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "CAS:7724-73-4" . [] oboInOwl:hasDbXref "PMID:12686928" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011075 ; owl:annotatedTarget "A green staining of teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011075 ; owl:annotatedTarget "Green colored teeth" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011075 ; owl:annotatedTarget "Green coloured teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011075 ; owl:annotatedTarget "Green teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011075 ; owl:annotatedTarget "Green tooth shade" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "PMID:12651883" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011076 ; owl:annotatedTarget "An abnormality of premolar tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011076 ; owl:annotatedTarget "Abnormality of bicuspid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011076 ; owl:annotatedTarget "Abnormality of premolar" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "6-deoxygalactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011077 ; owl:annotatedTarget "An abnormality of molar tooth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011077 ; owl:annotatedTarget "Abnormality of molar" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "Fucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011078 ; owl:annotatedTarget "An abnormality of canine tooth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011078 ; owl:annotatedTarget "Abnormality of canine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011078 ; owl:annotatedTarget "Abnormality of eye tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011079 ; owl:annotatedTarget "A tooth that has not erupted because of local impediments (overcrowding or fibrous gum overgrowth)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011079 ; owl:annotatedTarget "Buried tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011079 ; owl:annotatedTarget "Impacted tooth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "fucose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011080 ; owl:annotatedTarget "An abnormality of morphology of premolar tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011080 ; owl:annotatedTarget "Abnormality of bicuspid morphology" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011080 ; owl:annotatedTarget "Abnormality of shape of bicuspid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011080 ; owl:annotatedTarget "Abnormality of shape of premolar" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "6-Deoxygalactose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Increased size of the incisor tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Hyperplasia of incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Hypertrophy of incisor" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_33984 ; owl:annotatedTarget "Fuc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Increased size of incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Large incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011081 ; owl:annotatedTarget "Increased width of incisor" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "Spinacene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "An abnormal conical morphology of the primary incisor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Cone shaped front baby tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Conical deciduous incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Conoid primary incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Primary front shark tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Peg shaped front baby tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Peg shaped primary incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Pointed front baby tooth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011082 ; owl:annotatedTarget "Pointed primary incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "An abnormal conical morphology of either maxillary primary incisor tooth or maxillary permanent incisor tooth or both." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Cone shaped maxillary incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Cone shaped upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Conoid maxillary incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Upper front shark tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Peg shaped upper front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Pointed maxillary incisor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011083 ; owl:annotatedTarget "Pointed upper front tooth" . [] oboInOwl:hasDbXref "PMID:18499550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011084 ; owl:annotatedTarget "A form of hypomineralization of enamel characterized by reduced calcification." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011084 ; owl:annotatedTarget "Decreased enamel calcification" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011084 ; owl:annotatedTarget "Poorly calcified tooth enamel" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011085 ; owl:annotatedTarget "A form of hypomineralization of enamel characterized by a chalky appearance of the enamel with orange, brown, or white color." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011085 ; owl:annotatedTarget "Immature tooth enamel" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011085 ; owl:annotatedTarget "Soft teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011085 ; owl:annotatedTarget "Soft tooth enamel" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_3424 ; owl:annotatedTarget "CAS:406-76-8" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011086 ; owl:annotatedTarget "Developmental dysplasia of dentin or both the primary dentition and the permanent dentition." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011086 ; owl:annotatedTarget "Dentinogenesis imperfecta of adult and baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011086 ; owl:annotatedTarget "Dentinogenesis imperfecta of both sets of teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011087 ; owl:annotatedTarget "Talon cusp is an accessory cusp located near the cingulum (the portion of the lingual or palatal aspect of the tooth that forms a convex protuberance at the cervical third of the anatomic crown)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011087 ; owl:annotatedTarget "Extra cusp on inside of front tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011087 ; owl:annotatedTarget "Dens evaginatus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011087 ; owl:annotatedTarget "Talon cusps" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011088 ; owl:annotatedTarget "An abnormality of the incisor characterized by invagination of the enamel, giving a radiographic appearance that suggests a tooth within a tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011088 ; owl:annotatedTarget "Dens invaginatus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011088 ; owl:annotatedTarget "Tooth within a tooth" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_3424 ; owl:annotatedTarget "CAS:461-06-3" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011089 ; owl:annotatedTarget "Fusion of two adjacent teeth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011089 ; owl:annotatedTarget "Conjoined teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011089 ; owl:annotatedTarget "Double tooth" . [] oboInOwl:hasDbXref "PMID:18167487" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011090 ; owl:annotatedTarget "The union of two separately developing tooth germs typically leading to one less tooth than normal in the affected dental arch." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011090 ; owl:annotatedTarget "Fused teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011090 ; owl:annotatedTarget "Fusion of teeth" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011090 ; owl:annotatedTarget "Joined teeth" . [] oboInOwl:hasDbXref "PMID:18167487" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011091 ; owl:annotatedTarget "The development of two teeth from a single tooth bud, leading to a larger fused tooth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011091 ; owl:annotatedTarget "Gemination of tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011091 ; owl:annotatedTarget "Splitting of crown of tooth" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3424 ; owl:annotatedTarget "3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011092 ; owl:annotatedTarget "Syphilitic permanent first molar" . [] oboInOwl:hasDbXref , "PMID:15587104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Increased size and molar morphology of premolar tooth." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3424 ; owl:annotatedTarget "3-hydroxy-4-(trimethylammonio)butanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Molar shape of bicuspid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Molar shape of premolar" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Molarization of bicuspid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Enlarged premolar" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011093 ; owl:annotatedTarget "Increased size of premolar" . [] oboInOwl:hasDbXref , "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Maxillary teeth cover the mandibular teeth when biting to an increased degree. The feature is defined as a vertical overlap of the maxillary incisors over the mandibular incisors that exceeds 2 mm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Increased overlap of upper and lower incisors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Overbite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Deep bite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Deep overbite" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3424 ; owl:annotatedTarget "Carnitine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011094 ; owl:annotatedTarget "Scissors bite" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "An abnormal anteroposterior extension of the maxillary teeth beyond the plane of the mandibular teeth upon jaw closure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "Abnormality of horizontal incisor relationship" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "Protrusion of upper teeth in front of lower teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "Buck teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "Protrusion of the maxillary incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011095 ; owl:annotatedTarget "Upper teeth sticking out forward" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011096 ; owl:annotatedTarget "A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011097 ; owl:annotatedTarget "A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: Grimacing, head nodding, or subtle eye movements. Epileptic spasms frequently occur in clusters. Infantile spasms are the best known form, but spasms can occur at all ages" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15440 ; owl:annotatedTarget "Supraene" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011097 ; owl:annotatedTarget "Epileptic spasms" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011097 ; owl:annotatedTarget "Salaam convulsions" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011097 ; owl:annotatedTarget "Salaam seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011098 ; owl:annotatedTarget "A type of apraxia that is characterized by difficulty or inability to execute speech movements because of problems with coordination and motor problems, leading to incorrect articulation. An increase of errors with increasing word and phrase length may occur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011099 ; owl:annotatedTarget "Unilateral paresis (weakness) with spasticity of the affected muscles and increased tendon reflexes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_350546 ; owl:annotatedTarget "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011100 ; owl:annotatedTarget "An abnormal closure, or atresia of the tubular structure of the intestine." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_350546 ; owl:annotatedTarget "serotonin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011102 ; owl:annotatedTarget "An abnormal closure, or atresia of the tubular structure of the ileum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011103 ; owl:annotatedTarget "An abnormality of the outflow tract of the left ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011104 ; owl:annotatedTarget "An abnormality in the amount of volume occupied by intravascular blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_350546 ; owl:annotatedTarget "serotonin cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011105 ; owl:annotatedTarget "An increase in the amount of intravascular fluid, particularly in the volume of the circulating blood." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/hypervolemia" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011105 ; owl:annotatedTarget "Fluid overload in blood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011106 ; owl:annotatedTarget "An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011106 ; owl:annotatedTarget "Depleted blood volume" . _:genid80234 oboInOwl:hasDbXref ; a owl:Axiom, owl:Restriction ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011107 ; owl:annotatedTarget "Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border." ; owl:onProperty obo:BFO_0000051 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:PATO_0000470 [ a owl:Restriction ; owl:onProperty obo:RO_0000052 ; owl:someValuesFrom [ a owl:Class ; owl:intersectionOf (obo:GO_0006954 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0002372 ] ) ] ] [ a owl:Restriction ; owl:onProperty obo:RO_0002573 ; owl:someValuesFrom obo:PATO_0000460 ] ) ] . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011107 ; owl:annotatedTarget "Recurrent canker sores" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011108 ; owl:annotatedTarget "A recurrent form of sinusitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011108 ; owl:annotatedTarget "Sinusitis, recurrent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011108 ; owl:annotatedTarget "Recurrent sinus disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011109 ; owl:annotatedTarget "A chronic form of sinusitis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35106 ; owl:annotatedTarget "nitrogen hydrides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011109 ; owl:annotatedTarget "Chronic sinus disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011109 ; owl:annotatedTarget "Sinusitis, chronic" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35107 ; owl:annotatedTarget "azanes" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0011110 ; owl:annotatedTarget _:genid80234 . [] oboInOwl:hasDbXref , "PMID:15897415" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011110 ; owl:annotatedTarget "Inflammation of the tonsils that has occurred repeatedly. The definition of recurrent may vary somewhat, but the criteria used recently as a measure of severity were five or more episodes of true tonsillitis per year, symptoms recurring for at least a year, and episodes that are disabling and that prevent normal functioning. In some cases recurrent tonsillitis may be related to immunosusceptibility. Evidence exists for a genetic predisposition for recurrent tonsillitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011110 ; owl:annotatedTarget "Recurrent inflammation of tonsils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011111 ; owl:annotatedTarget "An abnormality of the concentration or function of circulating immune proteins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011112 ; owl:annotatedTarget "Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells." . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35134 ; owl:annotatedTarget "metalloprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011113 ; owl:annotatedTarget "An abnormality in the production or cellular release of a cytokine (i.e., any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011114 ; owl:annotatedTarget "An impairment in the production by leukocytes of NFKB1-dependent cytokines such as tumor necrosis factor-alpha and interferon-alpha." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35134 ; owl:annotatedTarget "metalloproteine" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011117 ; owl:annotatedTarget "Abnormality of IL secretion" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/tumor_necrosis_factor_alpha" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011118 ; owl:annotatedTarget "Abnormality of cachectin secretion" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/tumor_necrosis_factor_alpha" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011118 ; owl:annotatedTarget "Abnormality of cachexin secretion" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011118 ; owl:annotatedTarget "Abnormality of tumour necrosis factor secretion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35134 ; owl:annotatedTarget "metalloproteins" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "An abnormality of the nasal dorsum, also known as the nasal ridge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Abnormality of the dorsum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Abnormality of the nasal ridge" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Abnormal morphology of dorsum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Crooked dorsum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Crooked nasal dorsum" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35136 ; owl:annotatedTarget "iron protein" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Crooked nasal ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Deformity of the dorsum of the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Deformity of the nasal dorsum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Deformity of the nasal ridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Malformation of the dorsum of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Malformation of the nasal dorsum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011119 ; owl:annotatedTarget "Malformation of the nasal ridge" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Boxer's nasal deformity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Boxer's nose deformity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35136 ; owl:annotatedTarget "iron proteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Concave dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Concave nasal dorsum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Saddle nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Saddle shaped nasal dorsum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Ski jump nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011120 ; owl:annotatedTarget "Saddle nose deformity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35136 ; owl:annotatedTarget "iron-containing proteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011121 ; owl:annotatedTarget "Any morphological abnormality of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011121 ; owl:annotatedTarget "Abnormal skin morphology" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011121 ; owl:annotatedTarget "Abnormal skin structure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011122 ; owl:annotatedTarget "Any abnormality of the physiological function of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011122 ; owl:annotatedTarget "Abnormality of skin physiology" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "hemoprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011123 ; owl:annotatedTarget "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011123 ; owl:annotatedTarget "Inflammatory abnormality of the skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011123 ; owl:annotatedTarget "Skin inflammation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "Haemoprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011124 ; owl:annotatedTarget "An abnormality of the morphology of the epidermis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011125 ; owl:annotatedTarget "An abnormality of the melanosomes, i.e., of the cellular organelles in which melanin pigments are synthesized and stored within melanocytes (the cells that produce pigment in the dermis)." . [] oboInOwl:hasDbXref , "PMID:18990154" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011126 ; owl:annotatedTarget "A significant descent of the kidney as the patient moves from the supine to the erect position." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011126 ; owl:annotatedTarget "Floating kidney" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "Haemprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011126 ; owl:annotatedTarget "Renal ptosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011127 ; owl:annotatedTarget "A type of eczema that occurs in the lips and perioral area." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011127 ; owl:annotatedTarget "Eczema around the mouth" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "haem protein" . [] oboInOwl:hasDbXref , "PMID:17322991" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011128 ; owl:annotatedTarget "A condition characterized by necrosis of the mucosal and submucosal layers of the esophagus not related to ingestion of caustic or other injurious agents. Endoscopically, there is a dark lesion ('black esophagus') distributed in a circumferential manner in the distal one-third of the esophagus with or without exudates. There is involvement of the distal esophagus ending sharply at the gastroesophageal junction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011129 ; owl:annotatedTarget "A bilateral form of fetal pyelectasis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011129 ; owl:annotatedTarget "Bilateral foetal pyelectasia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011129 ; owl:annotatedTarget "Bilateral foetal pyelectasis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "haemoprotein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011130 ; owl:annotatedTarget "Any abnormality of the morphology of the major calices or minor calices of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011131 ; owl:annotatedTarget "The presence of a rash (change of color and texture) of the perianal skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011131 ; owl:annotatedTarget "Perianal rash" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011132 ; owl:annotatedTarget "A furuncle (boil) is a skin infection involving an entire hair follicle and nearby skin tissue. Chronic furunculosis refers to recurrent episodes of furuncles, often caused by recurrent staphylococcus infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011133 ; owl:annotatedTarget "An abnormally increased sensitivity to the effects of ionizing radiation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011133 ; owl:annotatedTarget "Increased sensitivity to ionising radiation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011134 ; owl:annotatedTarget "Mild fever that does not exceed 38.5 degrees centigrade." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "heme protein" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011134 ; owl:annotatedTarget "Low-grade fever" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011134 ; owl:annotatedTarget "Mild fever" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011135 ; owl:annotatedTarget "Absence or developmental hypoplasia of the sweat glands." . [] oboInOwl:hasDbXref "IUBMB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "hemeproteins" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011135 ; owl:annotatedTarget "Absent/small sweat glands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011135 ; owl:annotatedTarget "Absent/underdeveloped sweat glands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011136 ; owl:annotatedTarget "Absence of the sweat glands." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35137 ; owl:annotatedTarget "hemoproteins" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011136 ; owl:annotatedTarget "Absent sweat glands" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011136 ; owl:annotatedTarget "Lack of sweat glands" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011137 ; owl:annotatedTarget "Pale reddish slightly elevated papules and plaques of 0.5-3 cm in diameter and not accompanied by pruritus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011137 ; owl:annotatedTarget "Non-itchy hives" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35143 ; owl:annotatedTarget "hemoglobin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011138 ; owl:annotatedTarget "An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011138 ; owl:annotatedTarget "Abnormal skin appendage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35143 ; owl:annotatedTarget "haemoglobin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011139 ; owl:annotatedTarget "Gastric duplication is a usually cystic malformation of gastrointestinal tract, usually attached to the greater curvature of the stomach and has no communication with the stomach." . [] oboInOwl:hasDbXref , "PMID:21218094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011140 ; owl:annotatedTarget "A spherical hollow structure with a smooth muscle coat, lined by a mucous membrane, and attached to any part of the gastrointestinal tract, from the base of the tongue to the anus." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011140 ; owl:annotatedTarget "GI duplication" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35143 ; owl:annotatedTarget "vertebrate haemoglobin" . [] oboInOwl:hasDbXref , "PMID:15708105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011141 ; owl:annotatedTarget "A type of cataract (opacification of the lens) that forms during the course of aging." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011141 ; owl:annotatedTarget "Clouding of the lens of the eye with age" . [] oboInOwl:hasDbXref , "PMID:15708105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011142 ; owl:annotatedTarget "A type of age-related cataract that primarily affects the nucleus of the lens." . [] oboInOwl:hasDbXref , "PMID:15708105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011143 ; owl:annotatedTarget "A type of age-related cataract that primarily affects the cortex of the lens." . [] oboInOwl:hasDbXref , "PMID:15708105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011144 ; owl:annotatedTarget "A type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule." . [] oboInOwl:hasDbXref "PMID:18184148" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011145 ; owl:annotatedTarget "A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed." . [] oboInOwl:hasDbXref "PMID:9738682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011146 ; owl:annotatedTarget "A dialeptic seizure is a type of seizure characterised predominantly by reduced responsiveness or awareness and with subsequent at least partial amnesia of the event." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011146 ; owl:annotatedTarget "Behavioural arrest seizure with impairment of awareness irrespective of onset" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276062", "PMID:28276064", "PMID:6790275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011147 ; owl:annotatedTarget "A typical absence seizure is a type of generalised non-motor (absence) seizure characterised by its sudden onset, interruption of ongoing activities, a blank stare, possibly a brief upward deviation of the eyes. Usually the patient will be unresponsive when spoken to. Duration is a few seconds to half a minute with very rapid recovery. Although not always available, an EEG would usually show 3 Hz generalized epileptiform discharges during the event." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011147 ; owl:annotatedTarget "Typical absence seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:19469840", "PMID:28276060", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011149 ; owl:annotatedTarget "An absence with eyelid myoclonia seizure is a type of generalized non-motor (absence) seizure characterised by forced upward jerking of the eyelids during an absence seizure." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011149 ; owl:annotatedTarget "Absence seizures with eyelid myoclonia" . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276062", "PMID:28276064", "PMID:9637609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011150 ; owl:annotatedTarget "Myoclonic absence seizure is a type of generalized non-motor (absence) seizure characterised by an interruption of ongoing activities, a blank stare and rhythmic three-per-second myoclonic movements, causing ratcheting abduction of the upper limbs leading to progressive arm elevation, and associated with 3 Hz generalized spike-wave discharges on the electroencephalogram. Duration is typically 10-60 s. Whilst impairment of consciousness may not be obvious the ILAE classified this seizure as a generalized non-motor seizure in 2017." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011150 ; owl:annotatedTarget "Myoclonic absences" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011151 ; owl:annotatedTarget "Atypical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged atypical absence seizure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011152 ; owl:annotatedTarget "Typical absence seizures starting before the age of 4 years." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011152 ; owl:annotatedTarget "Early onset petit mal seizures" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:jalbers", "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "A type of focal-onset seizure characterized by a motor sign as its initial semiological manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "Focal motor seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "Localised motor seizure" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "Beilstein:2067409" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "Localised motor seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "Localized motor seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011153 ; owl:annotatedTarget "Partial motor seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011154 ; owl:annotatedTarget "An autonomic seizure is a type of focal non-motor seizure characterized by alteration of autonomic nervous system function as the initial semiological feature." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011154 ; owl:annotatedTarget "Focal autonomic seizures" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011157 ; owl:annotatedTarget "A focal sensory seizure is a type seizure beginning with a subjective sensation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011157 ; owl:annotatedTarget "Focal sensory seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011158 ; owl:annotatedTarget "A seizure characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones as its first clinical manifestation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011159 ; owl:annotatedTarget "A type of focal autonomic seizure characterised by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011159 ; owl:annotatedTarget "Abdominal aura" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "CAS:7488-99-5" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011159 ; owl:annotatedTarget "Epigastric auras" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011159 ; owl:annotatedTarget "Visceral aura" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011160 ; owl:annotatedTarget "A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes as its first clinical manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011160 ; owl:annotatedTarget "Gustatory auras" . [] oboInOwl:hasDbXref , "http://medical-dictionary.thefreedictionary.com/gustatory+aura" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011160 ; owl:annotatedTarget "Taste hallucinations" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011161 ; owl:annotatedTarget "Seizures characterized by olfactory phenomena as its first clinical manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011161 ; owl:annotatedTarget "Olfactory auras" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011163 ; owl:annotatedTarget "A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move as its first clinical manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011163 ; owl:annotatedTarget "Somatosensory auras" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011165 ; owl:annotatedTarget "A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis as its first clinical manifestation." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "LIPID_MAPS_instance:LMPR01070011" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011165 ; owl:annotatedTarget "Visual auras" . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011166 ; owl:annotatedTarget "A type of focal motor seizure characterized by sudden, brief (<100 ms) involuntary single or multiple contraction(s) of muscles(s) or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011166 ; owl:annotatedTarget "Focal myoclonic seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011166 ; owl:annotatedTarget "Local myoclonic seizures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011166 ; owl:annotatedTarget "Partial myoclonic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011166 ; owl:annotatedTarget "Segmental myoclonic seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011167 ; owl:annotatedTarget "A type of focal motor seizure characterized by sustained increase in muscle contraction, lasting a few seconds to minutes." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011167 ; owl:annotatedTarget "Focal tonic seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011167 ; owl:annotatedTarget "Local tonic seizures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011167 ; owl:annotatedTarget "Partial tonic seizures" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "(6'R)-beta,epsilon-carotene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011168 ; owl:annotatedTarget "Focal seizure with eyelid myoclonia, not eyelid myoclonias in the context of absence seizures." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011169 ; owl:annotatedTarget "Generalized clonic seizure is a type of generalized motor seizure characterised by sustained bilateral jerking, either symmetric or asymmetric, that is regularly repetitive and involves the same muscle groups." . [] oboInOwl:hasSynonymType hp:plural_form, hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011169 ; owl:annotatedTarget "Generalised clonic seizures" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011169 ; owl:annotatedTarget "Generalized clonic seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011170 ; owl:annotatedTarget "A generalized myoclonic-atonic seizure is a type of generalized motor seizure characterized by a myoclonic jerk followed by an atonic motor component." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011170 ; owl:annotatedTarget "Myoclonic atonic seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:19125841", "PMID:6779259", "PMID:972656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011171 ; owl:annotatedTarget "A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/febrile_seizure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011171 ; owl:annotatedTarget "Simple febrile convulsion" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011171 ; owl:annotatedTarget "Simple febrile seizures" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/febrile_seizure" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011171 ; owl:annotatedTarget "Simple fever fit" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "(+)-alpha-carotene" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:19125841", "PMID:972656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011172 ; owl:annotatedTarget "A febrile seizure that has any of the following features: focal semiology (or associated with post-ictal neurologic abnormalities beyond drowsiness, such as a Todd's paresis), prolonged seizure beyond 15 minutes, or recurring (occurring more than once) in a 24 hour period." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011172 ; owl:annotatedTarget "Complex febrile seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011173 ; owl:annotatedTarget "A type of focal non-motor seizure characterized by an arrest or pause of activities, freezing, or immobilization as the predominant semiological feature throughout the seizure." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011173 ; owl:annotatedTarget "Focal behaviour arrest seizure" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011173 ; owl:annotatedTarget "Hypokinetic seizures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011173 ; owl:annotatedTarget "Partial seizure with behaviour arrest" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers", "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011174 ; owl:annotatedTarget "A focal seizure characterized at onset by predominantly proximal limb or axial muscles producing irregular sequential ballistic movements, such as pedaling, pelvic thrusting, thrashing, rocking movements." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011174 ; owl:annotatedTarget "Hyperkinetic seizures" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011175 ; owl:annotatedTarget "A type of focal motor seizure characterised by sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral deviation from the midline as the initial semiological manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011175 ; owl:annotatedTarget "Versive seizures" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35147 ; owl:annotatedTarget "alpha-carotene (natural)" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011176 ; owl:annotatedTarget "An EEG with constitutional variants contains waves that are rare or unusual but not generally pathologic." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011177 ; owl:annotatedTarget "EEG background activity at 4-5/second." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011178 ; owl:annotatedTarget "EEG dominated by diffuse alpha-waves (8-13Hz)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011179 ; owl:annotatedTarget "EEG dominated by diffuse beta-waves (>13 Hz)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011179 ; owl:annotatedTarget "Beta wave electroencephalography" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011180 ; owl:annotatedTarget "EEG dominated by diffuse beta waves (>13 Hz) with occipitally localized alpha waves (8-13 Hz)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011181 ; owl:annotatedTarget "EEG with an amplitude less than 30 microvolts without observable occipital alpha rhythm (8-13 Hz)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011182 ; owl:annotatedTarget "Epileptiform activity refers to distinctive EEG waves or complexes distinguished from background activity found in in a proportion of human subjects with epilepsy, but which can also be found in subjects without seizures. Interictal epileptiform activity refers to such activity that occurs in the absence of a clinical or subclinical seizure." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011183 ; owl:annotatedTarget "Focal epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011184 ; owl:annotatedTarget "Generalized epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011184 ; owl:annotatedTarget "EEG with hyperventilation-induced generalised epileptiform discharges" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011185 ; owl:annotatedTarget "EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011186 ; owl:annotatedTarget "Focal epileptiform discharges with spreading to contralateral hemisphere but without secondary generalization." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011187 ; owl:annotatedTarget "Focal epileptiform discharges with spreading to the hemisphere on the same side of the brain." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011188 ; owl:annotatedTarget "Focal EEG discharges that secondarily spread to both hemispheres and can then be recorded over the entire scalp." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011188 ; owl:annotatedTarget "Focal EEG discharges with secondary generalisation" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011189 ; owl:annotatedTarget "Epileptiform discharges being identified at multiple locations in both hemispheres." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011190 ; owl:annotatedTarget "Epileptiform discharges identified at multiple locations temporarily in both hemispheres and temporarily in one hemisphere." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011191 ; owl:annotatedTarget "Epileptiform discharges being identified at multiple locations in one hemisphere." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011192 ; owl:annotatedTarget "Focal epileptiform discharges of different shapes and frequencies." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35148 ; owl:annotatedTarget "Beilstein:2682045" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011193 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011194 ; owl:annotatedTarget "Focal spikes occurring for several seconds." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011195 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011196 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011197 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011198 ; owl:annotatedTarget "EEG discharges recorded on the entire scalp typically seen in persons with epilepsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011198 ; owl:annotatedTarget "EEG with generalised epileptiform discharges" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011199 ; owl:annotatedTarget "EEG with generalized sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011199 ; owl:annotatedTarget "EEG with generalised sharp slow waves" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011200 ; owl:annotatedTarget "Generalized epileptiform discharges of different shapes and frequencies." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35148 ; owl:annotatedTarget "(6'S)-beta,epsilon-carotene" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011200 ; owl:annotatedTarget "EEG with generalised polymorphic epileptiform discharges" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011201 ; owl:annotatedTarget "EEG with abnormal amplitude." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011202 ; owl:annotatedTarget "EEG frequency is abnormally increased." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011203 ; owl:annotatedTarget "EEG with abnormally slow frequencies." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011204 ; owl:annotatedTarget "EEG showing diffuse slowing without interruption." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011205 ; owl:annotatedTarget "Non-continuous diffuse slowing of electroencephalographic patterns." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011206 ; owl:annotatedTarget "Slowing at frequencies between 7.5 and 8.5 Hz." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011206 ; owl:annotatedTarget "EEG with generalised slow activity grade 1" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011207 ; owl:annotatedTarget "Generalized slowing of EEG activity at frequencies between 4-7 Hz." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011207 ; owl:annotatedTarget "EEG with generalised slow activity grade 2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35163 ; owl:annotatedTarget "cyclic carotene" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011208 ; owl:annotatedTarget "Generalized slowing of EEG activity at frequencies between 0.5-3 Hz." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011208 ; owl:annotatedTarget "EEG with generalised slow activity grade 3" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011209 ; owl:annotatedTarget "EEG without electrical activity." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011209 ; owl:annotatedTarget "EEG with generalised slow activity grade 4" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011210 ; owl:annotatedTarget "Slowing in occipital areas of the scalp EEG." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011211 ; owl:annotatedTarget "Occurrence of epileptiform discharges in occipital regions during photic stimulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011212 ; owl:annotatedTarget "Occurence of epileptiform discharges in occipital and central regions during photic stimulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011213 ; owl:annotatedTarget "Occurrence of epileptiform discharges in occipital, central, temporal and parietal regions during photic stimulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011214 ; owl:annotatedTarget "Occurrence of generalized epileptiform discharges during photic stimulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011215 ; owl:annotatedTarget "Hypsarrhythmia occurring in one hemisphere." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35163 ; owl:annotatedTarget "cyclic carotenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "An abnormal shape of occiput." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "Abnormal shape of posterior head" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "Abnormal shape of the back of the head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "Abnormal shape of posterior cranium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "Abnormal shape of posterior skull" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011217 ; owl:annotatedTarget "Abnormal shape of the back of the skull" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35179 ; owl:annotatedTarget "MetaCyc:2-Oxo-carboxylates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011218 ; owl:annotatedTarget "An abnormal shape of the frontal part of the head." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011218 ; owl:annotatedTarget "Abnormal morphology of the frontal region" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011218 ; owl:annotatedTarget "Abnormal shape of the forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011218 ; owl:annotatedTarget "Dysmorphic forehead" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011218 ; owl:annotatedTarget "Dysmorphic frontal region" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35179 ; owl:annotatedTarget "PMID:10850983" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Facial height (length) is more than two standard deviations below the mean (objective); or an apparent decrease in the height (length) of the face (subjective)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Decreased height of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Decreased length of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Decreased vertical dimension of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Short face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Short facies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical Facial Deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical deficiency of face" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35179 ; owl:annotatedTarget "2-oxo monocarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical facial insufficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical hypoplasia of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical insufficiency of face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011219 ; owl:annotatedTarget "Vertical shortening of face" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Forward prominence of the entire forehead, due to protrusion of the frontal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Prominence of frontal region" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Prominent forehead" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Pronounced forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Protruding forehead" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011220 ; owl:annotatedTarget "Bulging forehead" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35179 ; owl:annotatedTarget "2-oxo monocarboxylic acid anions" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011221 ; owl:annotatedTarget "Vertical soft tissue creases in the midline of the forehead, often extending from the hairline to the brow, and seen with facial expression or when the face is at rest." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011221 ; owl:annotatedTarget "Frontal creases of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011221 ; owl:annotatedTarget "Vertical forehead creases" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011221 ; owl:annotatedTarget "Vertical forehead wrinkles" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011222 ; owl:annotatedTarget "Posterior positioning of the glabella, i.e., of the midline forehead between the supraorbital ridges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011222 ; owl:annotatedTarget "Deficient area between the eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011222 ; owl:annotatedTarget "Flat area between the eyebrows" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011223 ; owl:annotatedTarget "Linear vertical groove in the midline of the forehead, extending from hairline to glabella." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011223 ; owl:annotatedTarget "Depression of frontal cranial suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011223 ; owl:annotatedTarget "Depression of metopic cranial suture" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35179 ; owl:annotatedTarget "a 2-oxocarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011223 ; owl:annotatedTarget "Frontal suture depression" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011224 ; owl:annotatedTarget "Absent eyelids." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011224 ; owl:annotatedTarget "Absent eyelids" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "terpene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011224 ; owl:annotatedTarget "Agenesis of eyelids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011224 ; owl:annotatedTarget "Missing eyelids" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011225 ; owl:annotatedTarget "Redundant eyelid skin pressing the eyelashes against the cornea and/or conjunctiva." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "terpenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011226 ; owl:annotatedTarget "Absence or underdevelopment of the eyelid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011226 ; owl:annotatedTarget "Failure of development of eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011226 ; owl:annotatedTarget "Hypotrophic eyelid" . [] oboInOwl:hasDbXref , "PMID:28722873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011227 ; owl:annotatedTarget "An abnormal elevation of the C-reactive protein level in the blood circulation." . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "An eyebrow that extends straight across the brow, without curve." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Lack of eyebrow arch" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Lack of eyebrow curvature" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Flat eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Horizontal eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Straight eyebrow" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "Terpen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011228 ; owl:annotatedTarget "Straight eyebrows" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Regional increase in the width (height) of the eyebrow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Broad eyebrow" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "terpenes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Broad eyebrows" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Flared eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Increased vertical height of eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Increased vertical thickness of eyebrow" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Flared eyebrows" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011229 ; owl:annotatedTarget "Increased vertical width of eyebrow" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011230 ; owl:annotatedTarget "An eyebrow that extends laterally beyond the orbital rim rather than turning gently downward at that location." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011230 ; owl:annotatedTarget "Increased lateral length of eyebrow" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011230 ; owl:annotatedTarget "Laterally elongated eyebrow" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011230 ; owl:annotatedTarget "Laterally extended eyebrows" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "terpeno" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011231 ; owl:annotatedTarget "Eyelashes that draw the attention of the viewer due to increased density and/or length and/or curl without meeting the criteria of trichomegaly." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011231 ; owl:annotatedTarget "Prominent eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011231 ; owl:annotatedTarget "Thick eyelashes" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011232 ; owl:annotatedTarget "Elevated ridge(s) of skin starting well below the medial aspect of the lower lid that curves gradually upward toward and/or across the nasal bridge." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011233 ; owl:annotatedTarget "Antihelix protrusion directed more anteriorly than laterally, forming a shelf overlying the posterior concha." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35186 ; owl:annotatedTarget "terpenos" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011235 ; owl:annotatedTarget "Supernumerary ridge or crus of the ear arising from the antihelix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011236 ; owl:annotatedTarget "Antihelical ridge that forms an acute angle between the antitragus and its bifurcation (stem) instead of a gently curving arc." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011237 ; owl:annotatedTarget "Increased width of the inferred cross-section of the inferior crus." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011239 ; owl:annotatedTarget "Decreased protrusion of the inferior crus relative to the prominence of the antihelix stem." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011240 ; owl:annotatedTarget "Increased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of the helix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011241 ; owl:annotatedTarget "Posterior curving of the antihelix from its origin at the antitragus, traveling initially almost perpendicular to the descending helix and obscuring some of the concha." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011242 ; owl:annotatedTarget "Decreased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of a normal helix." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011243 ; owl:annotatedTarget "An abnormality of the inferior crus of the antihelix is the lower cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35190 ; owl:annotatedTarget "diterpenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011244 ; owl:annotatedTarget "An abnormality of the stem of the antihelix, which is the part below the bifurcation of the antihelix into the inferior and superior crura." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011245 ; owl:annotatedTarget "An abnormality of the superior crus of the antihelix is the upper cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011246 ; owl:annotatedTarget "Decreased protrusion of the superior crus relative to the prominence of a normal antihelix stem." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011247 ; owl:annotatedTarget "Increased protrusion of the superior crus relative to the prominence of a normal antihelix stem." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35190 ; owl:annotatedTarget "Diterpen" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011248 ; owl:annotatedTarget "Positioning of the antitragus at an angle perpendicular to the plane of the ear (oriented away from the plane of the ear)." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011249 ; owl:annotatedTarget "Absence of the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Beilstein:2224724" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35190 ; owl:annotatedTarget "diterpenes" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011250 ; owl:annotatedTarget "Double rather than single peak of the antitragus." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35190 ; owl:annotatedTarget "diterpeno" . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011251 ; owl:annotatedTarget "Reduction in the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011252 ; owl:annotatedTarget "Invagination of the superior part of the auricle under a fold of temporal skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011252 ; owl:annotatedTarget "Buried ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011252 ; owl:annotatedTarget "Hidden ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011253 ; owl:annotatedTarget "A type of cryptotia associated with reduction in size of the antihelix and superior crus." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35190 ; owl:annotatedTarget "diterpenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011254 ; owl:annotatedTarget "A type of cryptotia associated with reduction in size of the antihelix and inferior crus that are affected." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011255 ; owl:annotatedTarget "Continuum between the tragus and ascending helix, without any evidence of a posterior extension (crus) towards the concha." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011256 ; owl:annotatedTarget "Extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011257 ; owl:annotatedTarget "Curving course of the crus of the helix, approaching or joining the antitragus." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011258 ; owl:annotatedTarget "The anterior origin of the crus encompasses the superior margin of the tragus, the crus overrides the upper portion of the conchal cavum and ends at the antihelix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011259 ; owl:annotatedTarget "Widening, rather than tapering, of the crus at its posterior border near the antihelix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011260 ; owl:annotatedTarget "Small defect of the helical fold that lies at the junction of the superior and descending portions of the helix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011261 ; owl:annotatedTarget "Small expansion of the helical fold at the junction of the superior and descending portions of the helix." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011262 ; owl:annotatedTarget "Linear, circumferential indentation in the convexity of the outer surface of the helix." . [] oboInOwl:hasDbXref , "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011263 ; owl:annotatedTarget "Positioning of the anterior surface of the ear lobe in a more coronal plane than the remainder of the ear." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35191 ; owl:annotatedTarget "triterpenes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011263 ; owl:annotatedTarget "Forward facing earlobe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011263 ; owl:annotatedTarget "Lobe, forward facing" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011264 ; owl:annotatedTarget "Interruption between the ascending helix and the crus helix, allowing the ascending helix to be attached directly to the mastoid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35191 ; owl:annotatedTarget "Triterpen" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011265 ; owl:annotatedTarget "Discontinuity in the convexity of the inferior margin of the lobe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011265 ; owl:annotatedTarget "Cleft earlobe" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011266 ; owl:annotatedTarget "Presence of all the normal ear components and the median longitudinal length more than two standard deviations below the mean." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011267 ; owl:annotatedTarget "Presence of some auricular structures, but none of these structures conform to recognized ear components." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011267 ; owl:annotatedTarget "Abnormal shape/structure of ear" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35191 ; owl:annotatedTarget "triterpenes" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011268 ; owl:annotatedTarget "Lack of convexity or prominence of the contour of the ridge between the bottom of the incisura and the confluence of the ascending helix and crus helix." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35191 ; owl:annotatedTarget "triterpeno" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011269 ; owl:annotatedTarget "Increased height of the tragal ridge with a shallow indentation at the apex, giving the appearance of a double peak." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011269 ; owl:annotatedTarget "Notched tragus" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011270 ; owl:annotatedTarget "A complete or partial duplication of the tragus; expected to lie anterior to the normal tragus." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35191 ; owl:annotatedTarget "triterpenos" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Increase posterolateral protrusion of the tragus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Enlarged tragus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Hyperplastic tragus" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35193 ; owl:annotatedTarget "tetraterpenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Hypertrophic tragus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Large tragus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011271 ; owl:annotatedTarget "Tragus, prominent" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35193 ; owl:annotatedTarget "tetraterpenes" . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011272 ; owl:annotatedTarget "Decreased posterolateral protrusion of the tragus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011273 ; owl:annotatedTarget "Abnormally increased variability in the size of erythrocytes." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/anisocytosis" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011273 ; owl:annotatedTarget "Unequal size of red blood cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011274 ; owl:annotatedTarget "Increased susceptibility to mycobacterial infections, as manifested by recurrent episodes of mycobacterial infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011275 ; owl:annotatedTarget "Increased susceptibility to mycobacterial avium complex infections, as manifested by recurrent episodes of mycobacterial infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011276 ; owl:annotatedTarget "Vascular abnormalities restricted to skin" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "CAS:363-24-6" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35193 ; owl:annotatedTarget "tetraterpeno" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011278 ; owl:annotatedTarget "A type of pulmonary sequestration that occurs within the visceral pleura of normal lung tissue, usually without communication with the tracheobronchial tree." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35193 ; owl:annotatedTarget "tetraterpenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011279 ; owl:annotatedTarget "An abnormal amount of hydrogencarbonate in the urine." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011279 ; owl:annotatedTarget "Abnormality of urine HCO3 concentration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35195 ; owl:annotatedTarget "surfactant" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011280 ; owl:annotatedTarget "An abnormality of calcium concentration in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011280 ; owl:annotatedTarget "Abnormality of urine Ca concentration" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35195 ; owl:annotatedTarget "surface active agent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011280 ; owl:annotatedTarget "Abnormality of urine Ca2+ concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35195 ; owl:annotatedTarget "surfactants" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011281 ; owl:annotatedTarget "An abnormal amount of urinary catecholamine concentration." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35219 ; owl:annotatedTarget "plant growth inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011282 ; owl:annotatedTarget "An abnormality of the hindbrain, also known as the rhombencephalon." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011282 ; owl:annotatedTarget "Abnormal shape of hindbrain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011283 ; owl:annotatedTarget "An abnormality of the metencephalon. The metencephalon is the part of the hindbrain that consists of the pons and the cerebellum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35219 ; owl:annotatedTarget "plant growth inhibitors" . [] oboInOwl:hasDbXref , "PMID:17965226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011284 ; owl:annotatedTarget "A type of aganglionic megacolon in which the aganglionic segment does not extend beyond the upper sigmoid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011285 ; owl:annotatedTarget "A type of aganglionic megacolon in which the aganglionic segment extends proximal to the sigmoid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011286 ; owl:annotatedTarget "A type of aganglionic megacolon in which the aganglionic segment comprises the entire colon." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011287 ; owl:annotatedTarget "EEG with sharp slow waves in the occipital region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011288 ; owl:annotatedTarget "EEG with sharp slow waves in the parietal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011289 ; owl:annotatedTarget "EEG with sharp slow waves in the temporal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011290 ; owl:annotatedTarget "EEG with sharp slow waves in the frontal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011291 ; owl:annotatedTarget "EEG with sharp slow waves in the central region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011292 ; owl:annotatedTarget "EEG with sharp waves in the occipital region, i.e., sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011293 ; owl:annotatedTarget "EEG with sharp waves in the central region, i.e., sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35219 ; owl:annotatedTarget "plant growth retardants" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011294 ; owl:annotatedTarget "EEG with sharp waves in the frontal region, i.e., sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011295 ; owl:annotatedTarget "EEG with sharp waves in the parietal region, i.e., sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011296 ; owl:annotatedTarget "EEG with sharp waves in the temporal region, i.e., sharp transient waves of a duration between 80 and 200 msec." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35221 ; owl:annotatedTarget "antimetabolite" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011297 ; owl:annotatedTarget "A morphological abnormality of a digit, i.e., of a finger or toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011297 ; owl:annotatedTarget "Abnormality of fingers or toes" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011298 ; owl:annotatedTarget "A soft tissue prominence of the ventral aspects of the fingertips or toe tips." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011298 ; owl:annotatedTarget "Prominent digit pad" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011299 ; owl:annotatedTarget "The absence of a phalangeal segment of a finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011299 ; owl:annotatedTarget "Partial absence of finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35221 ; owl:annotatedTarget "antimetabolites" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011300 ; owl:annotatedTarget "Increased width of the distal segment of a finger." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011300 ; owl:annotatedTarget "Broad fingertip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011300 ; owl:annotatedTarget "Broad fingertips" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "CAS:363-24-6" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35222 ; owl:annotatedTarget "inhibitor" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011301 ; owl:annotatedTarget "The total absence of the foot, with no bony elements distal to the tibia or fibula." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011301 ; owl:annotatedTarget "Absent foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35222 ; owl:annotatedTarget "inhibidor" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011302 ; owl:annotatedTarget "For children from birth to 16 years of age the length of the palm is more than the 97th centile; or, the length of the palm appears relatively long compared to the finger length or the limb length." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011302 ; owl:annotatedTarget "Long palm" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011303 ; owl:annotatedTarget "The contour of the foot in lateral profile has a convex shape." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35222 ; owl:annotatedTarget "inhibiteur" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011304 ; owl:annotatedTarget "Increased thumb width without increased dorso-ventral dimension." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011304 ; owl:annotatedTarget "Broad thumb" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011304 ; owl:annotatedTarget "Broad thumbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011304 ; owl:annotatedTarget "Wide/broad thumb" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011305 ; owl:annotatedTarget "The absence of a phalangeal segment of a toe or hallux." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011305 ; owl:annotatedTarget "Partial absence of toe" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011307 ; owl:annotatedTarget "Divergence of digits along the anteroposterior axis (in the plane of the sole)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011307 ; owl:annotatedTarget "Splayed toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35222 ; owl:annotatedTarget "inhibitors" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011308 ; owl:annotatedTarget "Toes that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011308 ; owl:annotatedTarget "Narrow toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011308 ; owl:annotatedTarget "Slender toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35223 ; owl:annotatedTarget "catalyst" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011309 ; owl:annotatedTarget "The gradual reduction in girth of the toe from proximal to distal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011309 ; owl:annotatedTarget "Tapered toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011309 ; owl:annotatedTarget "Tapering toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35223 ; owl:annotatedTarget "Katalysator" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011310 ; owl:annotatedTarget "A crease that connects the proximal and distal transverse palmar creases." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011310 ; owl:annotatedTarget "Bridged palm line" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011311 ; owl:annotatedTarget "Extension of the proximal transverse crease (five finger crease) to the ulnar edge of the palm." . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011312 ; owl:annotatedTarget "A nail plate that has a longitudinal separation with partially separated nails, each with a separate lateral radius of curvature." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011312 ; owl:annotatedTarget "Fused nails" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35223 ; owl:annotatedTarget "catalizador" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011313 ; owl:annotatedTarget "Decreased width of nail." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011313 ; owl:annotatedTarget "Narrow nail" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35223 ; owl:annotatedTarget "catalyseur" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011314 ; owl:annotatedTarget "An abnormality of size or shape of the long bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011314 ; owl:annotatedTarget "Abnormal shape of long bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011315 ; owl:annotatedTarget "Synostosis affecting only one of the coronal sutures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011315 ; owl:annotatedTarget "Unilateral coronal suture craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011315 ; owl:annotatedTarget "Unilateral coronal suture synostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011316 ; owl:annotatedTarget "Synostosis affecting only the left coronal suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011317 ; owl:annotatedTarget "Unicoronal synostosis affecting only the right coronal suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011318 ; owl:annotatedTarget "Synostosis affecting the right and the left coronal suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011318 ; owl:annotatedTarget "Bilateral coronal craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011318 ; owl:annotatedTarget "Bilateral coronal suture craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011318 ; owl:annotatedTarget "Bilateral coronal suture synostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011319 ; owl:annotatedTarget "Premature synostosis of both lambdoid sutures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011319 ; owl:annotatedTarget "Bilateral lambdoid craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011320 ; owl:annotatedTarget "Premature synostosis of only one lambdoid suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011320 ; owl:annotatedTarget "Unilateral lambdoid craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011321 ; owl:annotatedTarget "Premature synostosis of only the left lambdoid suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011322 ; owl:annotatedTarget "Premature synostosis of only the right lambdoid suture." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011323 ; owl:annotatedTarget "Incomplete fusion of the chin, resulting from a developmental defect and manifesting as a midline cleft or fissure of the chin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011323 ; owl:annotatedTarget "Cleft of chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011323 ; owl:annotatedTarget "Midline defect of chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011324 ; owl:annotatedTarget "Craniosynostosis involving at least 2 cranial sutures, where the exact pattern of sutures fused has not been precisely specified." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011325 ; owl:annotatedTarget "Craniosynostosis of all calvarial sutures." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Drug_Central:913" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011325 ; owl:annotatedTarget "Sysnostosis of all cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Asymmetry of the anterior part of the skull." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Anterior flat head syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Deformational frontal plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Frontal plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Deformational anterior plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Positional anterior plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Positional frontal plagiocephaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Coronal synostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011326 ; owl:annotatedTarget "Unicoronal craniosynostosis" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35237 ; owl:annotatedTarget "Gmelin:49992" . [] oboInOwl:hasDbXref , "PMID:10876272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011327 ; owl:annotatedTarget "Asymmetry of the posterior part of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011327 ; owl:annotatedTarget "Deformational posterior plagiocephaly" . [] oboInOwl:hasDbXref , "PMID:12825844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011328 ; owl:annotatedTarget "An abnormality of the fontanelle." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35237 ; owl:annotatedTarget "2-ammonio-3-sulfanylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011329 ; owl:annotatedTarget "Any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011329 ; owl:annotatedTarget "Abnormality of cranial sutures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011330 ; owl:annotatedTarget "Premature fusion of the metopic suture." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35237 ; owl:annotatedTarget "cysteine zwitterion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011330 ; owl:annotatedTarget "Metopic craniosynostosis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011331 ; owl:annotatedTarget "Unilateral atrophy of facial tissues, including muscles, bones and skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011331 ; owl:annotatedTarget "Atrophy of half of face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011331 ; owl:annotatedTarget "Atrophy of one side of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011331 ; owl:annotatedTarget "Facial hemiatrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011332 ; owl:annotatedTarget "Unilateral underdevelopment of the facial tissues, including muscles and bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011332 ; owl:annotatedTarget "Decreased size of half of the face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011332 ; owl:annotatedTarget "Decreased size of one side of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011333 ; owl:annotatedTarget "Asymmetry observed in the face of a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011333 ; owl:annotatedTarget "Asymmetric crying face" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35237 ; owl:annotatedTarget "(+)H3N-CH(CH2SH)-COO(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011333 ; owl:annotatedTarget "Partial unilateral facial paresis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011333 ; owl:annotatedTarget "Hypoplasia of depressor angula oris muscle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011334 ; owl:annotatedTarget "Facial shape deformation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011334 ; owl:annotatedTarget "Distortion of facial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011335 ; owl:annotatedTarget "Excessive amount of hair growth on forehead." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011335 ; owl:annotatedTarget "Hairy forehead" . [] oboInOwl:hasDbXref , "PMID:1401310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011336 ; owl:annotatedTarget "Bilateral temporal scarlike defects, which are said to resemble forceps marks." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35237 ; owl:annotatedTarget "2-ammonio-3-mercaptopropanoate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011337 ; owl:annotatedTarget "Abnormality of mouth size" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011337 ; owl:annotatedTarget "Anomaly of mouth size" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35238 ; owl:annotatedTarget "amino acid zwitterion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jhurst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011338 ; owl:annotatedTarget "An abnormality of the outline, configuration, or contour of the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011338 ; owl:annotatedTarget "Abnormality of mouth shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011338 ; owl:annotatedTarget "Anomaly of mouth shape" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011338 ; owl:annotatedTarget "Unusual mouth shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011339 ; owl:annotatedTarget "An abnormality of the vermilion border, the sharp demarcation between the lip (red colored) and the adjacent normal skin." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011339 ; owl:annotatedTarget "Abnormality of the red part of the upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011339 ; owl:annotatedTarget "Anomaly of the upper lip vermillion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011339 ; owl:annotatedTarget "Deformity of the upper lip vermillion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011339 ; owl:annotatedTarget "Malformation of the upper lip vermillion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011340 ; owl:annotatedTarget "A subtle unilateral cleft of the upper lip, which may appear as a small indentation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011340 ; owl:annotatedTarget "Incomplete cheiloschisis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011340 ; owl:annotatedTarget "Incomplete cleft of the upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011340 ; owl:annotatedTarget "Notched cleft of the upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011340 ; owl:annotatedTarget "Partial cleft of the upper lip" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35243 ; owl:annotatedTarget "Beilstein:3935647" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jhurst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011341 ; owl:annotatedTarget "Increased width of the upper lip." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011341 ; owl:annotatedTarget "Elongation of upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011341 ; owl:annotatedTarget "Increased height of upper lip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011341 ; owl:annotatedTarget "Increased vertical length of upper lip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011341 ; owl:annotatedTarget "Long upper lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011342 ; owl:annotatedTarget "A mild delay in the achievement of motor or mental milestones in the domains of development of a child." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35243 ; owl:annotatedTarget "Gmelin:2060272" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011342 ; owl:annotatedTarget "Psychomotor retardation, mild" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011343 ; owl:annotatedTarget "A moderate delay in the achievement of motor or mental milestones in the domains of development of a child." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011343 ; owl:annotatedTarget "Psychomotor retardation, moderate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011344 ; owl:annotatedTarget "A severe delay in the achievement of motor or mental milestones in the domains of development of a child." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011344 ; owl:annotatedTarget "Severe psychomotor retardation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011345 ; owl:annotatedTarget "A moderate delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011346 ; owl:annotatedTarget "A mild delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011347 ; owl:annotatedTarget "An abnormality involving the movement of the eye outwards." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA03010003" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35243 ; owl:annotatedTarget "2-ammonio-3-hydroxypropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011348 ; owl:annotatedTarget "Any structural abnormality of the abducens nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011350 ; owl:annotatedTarget "A mild delay in the acquisition of the ability to understand the speech of others." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011351 ; owl:annotatedTarget "A moderate delay in the acquisition of the ability to understand the speech of others." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011352 ; owl:annotatedTarget "A severe delay in the acquisition of the ability to understand the speech of others." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011353 ; owl:annotatedTarget "Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35243 ; owl:annotatedTarget "serine zwitterion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011354 ; owl:annotatedTarget "An abnormality of the skin that is not localized to any one particular region." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011354 ; owl:annotatedTarget "Generalised abnormality of skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011354 ; owl:annotatedTarget "Generalized abnormality of skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011355 ; owl:annotatedTarget "A lesion of the skin that is located in a specific region rather than being generalized." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011355 ; owl:annotatedTarget "Localised skin lesion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011355 ; owl:annotatedTarget "Localized skin lesion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011356 ; owl:annotatedTarget "An abnormality of the skin that is restricted to a particular body region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011358 ; owl:annotatedTarget "Reduced pigmentation of hair diffusely." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011358 ; owl:annotatedTarget "Generalised hypopigmentation of hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011359 ; owl:annotatedTarget "Hair that lacks the lustre (shine or gleam) of normal hair." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011359 ; owl:annotatedTarget "Dry hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011360 ; owl:annotatedTarget "An abnormality of the distribution of hair growth that is acquired during the course of life." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011360 ; owl:annotatedTarget "Acquired abnormal hair pattern" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35267 ; owl:annotatedTarget "quaternary ammonium ion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011361 ; owl:annotatedTarget "A congenital abnormality of the distribution of hair growth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011361 ; owl:annotatedTarget "Abnormal hair pattern since birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011362 ; owl:annotatedTarget "An abnormal amount of hair." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35267 ; owl:annotatedTarget "Quaternary amine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011362 ; owl:annotatedTarget "Abnormal hair quantity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011363 ; owl:annotatedTarget "Hair whose growth rate deviates from the norm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011363 ; owl:annotatedTarget "Abnormality of hair growth rate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011363 ; owl:annotatedTarget "Abnormality of pace of hair growth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011363 ; owl:annotatedTarget "Abnormality of speed of hair growth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011364 ; owl:annotatedTarget "Hypopigmented hair that appears white." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011364 ; owl:annotatedTarget "White hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011365 ; owl:annotatedTarget "Reduced pigmentation of hair in patches." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011367 ; owl:annotatedTarget "Yellowish discoloration of the nails." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011367 ; owl:annotatedTarget "Yellow nails" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35267 ; owl:annotatedTarget "a quaternary ammonium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011368 ; owl:annotatedTarget "Thickening of the epidermal layer of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011369 ; owl:annotatedTarget "Congenital deep dermal melanosis in the sacral area." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011371 ; owl:annotatedTarget "Recurrent viral skin infections" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35267 ; owl:annotatedTarget "quaternary ammonium ions" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011372 ; owl:annotatedTarget "Absence of the inner ear due to a developmental defect." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011372 ; owl:annotatedTarget "Absent inner ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011373 ; owl:annotatedTarget "Incomplete formation of the cochlear partition. The scala vestibuli and scala tympani separated by the cochlear partition, except in the apical turn where the two scalae are in continuity via the helicotrema." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz", "PMID:21849370" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011374 ; owl:annotatedTarget "Incomplete partition I is also known as cystic cochleovestibular malformation, where the cochlea has no bony modiolus, resulting in an empty cystic cochlea. This is accompanied by a dilated cystic vestibule with developmental arrest at the fifth week of gestation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35274 ; owl:annotatedTarget "ammonium ion derivatives" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011375 ; owl:annotatedTarget "Absence of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011375 ; owl:annotatedTarget "Absent cochlea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35274 ; owl:annotatedTarget "azanium ion derivative" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011376 ; owl:annotatedTarget "A morphological abnormality of the vestibule, the central part of the osseous labyrinth that is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:11279302" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35274 ; owl:annotatedTarget "azanium ion derivatives" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011377 ; owl:annotatedTarget "Complete absence of the vestibule of the inner ear." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011377 ; owl:annotatedTarget "Absent vestibule" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35281 ; owl:annotatedTarget "betaines" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011378 ; owl:annotatedTarget "Underdevelopment of the vestibule of the inner ear." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011379 ; owl:annotatedTarget "Dilatation of the vestibule of the inner ear." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35281 ; owl:annotatedTarget "onium betaines" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011380 ; owl:annotatedTarget "An abnormality of the morphology of the semicircular canal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35284 ; owl:annotatedTarget "ammonium betaines" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011381 ; owl:annotatedTarget "Absence of the semicircular canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011381 ; owl:annotatedTarget "Absent semicircular canal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35313 ; owl:annotatedTarget "hexoside" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011382 ; owl:annotatedTarget "Underdevelopment of the semicircular canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011382 ; owl:annotatedTarget "Small semicircular canal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011382 ; owl:annotatedTarget "Hypoplasia of the semicircular canals" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35313 ; owl:annotatedTarget "hexosides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011383 ; owl:annotatedTarget "Increased size of the semicircular canal." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35341 ; owl:annotatedTarget "Steroid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011384 ; owl:annotatedTarget "An abnormality of the Internal acoustic meatus, i.e., of the canal in the petrous part of the temporal bone through which the cranial nerve VII and cranial nerve VIII traverse." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35341 ; owl:annotatedTarget "steroids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011385 ; owl:annotatedTarget "Aplasia of the internal auditory canal." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011386 ; owl:annotatedTarget "Reduction in diameter of the internal auditory canal." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35341 ; owl:annotatedTarget "a steroid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011387 ; owl:annotatedTarget "Increased size of the vestibular aqueduct." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35342 ; owl:annotatedTarget "17-alpha-Hydroxysteroid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011388 ; owl:annotatedTarget "Increased size of the cochlear duct, i.e., of a duct that communicates between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:12746806" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35342 ; owl:annotatedTarget "17alpha-hydroxy steroids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011389 ; owl:annotatedTarget "An abnormality of the function of the inner ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011389 ; owl:annotatedTarget "Functional abnormality of the inner ear" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35343 ; owl:annotatedTarget "17beta-hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011390 ; owl:annotatedTarget "A structural anomaly of the internal part of the ear." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35343 ; owl:annotatedTarget "17beta-hydroxysteroid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35343 ; owl:annotatedTarget "17beta-hydroxysteroids" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011393 ; owl:annotatedTarget "Absence of the vestibular nerve" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011393 ; owl:annotatedTarget "Absent cranial nerve viii" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011393 ; owl:annotatedTarget "Absent the eighth cranial nerve" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35343 ; owl:annotatedTarget "a 17beta-hydroxy steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011393 ; owl:annotatedTarget "Absent vestribular nerve" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011394 ; owl:annotatedTarget "Underdevelopment of the vestibular nerve." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35344 ; owl:annotatedTarget "21-Hydroxysteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011395 ; owl:annotatedTarget "Absence or underdevelopment of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011395 ; owl:annotatedTarget "Absent/small cochlea" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011395 ; owl:annotatedTarget "Absent/underdeveloped cochlea" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35344 ; owl:annotatedTarget "21-hydroxy steroids" . [] oboInOwl:hasDbXref "PMID:30726044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011396 ; owl:annotatedTarget "Any anomaly of the cohclear nerve, which is the part of the vestibulocochlear nerve that is responsible for transmitting auditory signals from the inner ear to the cochlear nuclei within the brainstem and ultimately to the primary auditory cortex within the temporal lobe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35344 ; owl:annotatedTarget "21-hydroxysteroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011397 ; owl:annotatedTarget "An abnormality of the dorsal columns, i.e., of the dorsal portion of the gray substance of the spinal cord. The dorsal column consists of the fasciculus gracilis and fasciculus cuneatus and itself is part of the dorsal funiculus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35346 ; owl:annotatedTarget "11beta-Hydroxysteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011399 ; owl:annotatedTarget "Wasting of the tibialis anterior muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011399 ; owl:annotatedTarget "Tibialis muscle degeneration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35346 ; owl:annotatedTarget "11beta-hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011400 ; owl:annotatedTarget "An abnormality of myelination of nerves in the central nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011401 ; owl:annotatedTarget "Delayed myelination in the peripheral nervous system." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:12859290" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35346 ; owl:annotatedTarget "11beta-hydroxysteroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011402 ; owl:annotatedTarget "Demyelination of peripheral sensory nerves." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011404 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs that is lethal at birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011406 ; owl:annotatedTarget "A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in infancy." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35346 ; owl:annotatedTarget "an 11beta-hydroxysteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011408 ; owl:annotatedTarget "Intrauterine growth retardation that is at least 3 standard deviations (SD) below average, but not as low as 4 SD, corrected for sex and gestational age." . [] oboInOwl:hasDbXref "PMID:28939208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011409 ; owl:annotatedTarget "Structural anomaly of the fetal membranes (also known as the amniochorionic or placental membranes), which comprise a vital intrauterine compartment, where they perform mechanical, immune, and endocrine functions to promote growth of the fetus and protection from environmental adversity. Amniochorionic membranes anatomically consist of a single layer of cuboidal amnion epithelial cells, chorionic trophoblasts, and scattered fibroblasts connected by a layer of type IV collagen-rich extracellular matrix." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011410 ; owl:annotatedTarget "Caesarian section" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35348 ; owl:annotatedTarget "3beta-hydroxysteroids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011411 ; owl:annotatedTarget "Forceps delivery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011412 ; owl:annotatedTarget "Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011412 ; owl:annotatedTarget "Vacuum extraction" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011412 ; owl:annotatedTarget "Vacuum-assisted vaginal delivery" . [] oboInOwl:hasDbXref "PMID:15086043" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011413 ; owl:annotatedTarget "Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011414 ; owl:annotatedTarget "An abnormality of the placenta in which there are numerous cystic spaces within the placenta as well as placental enlargement." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35348 ; owl:annotatedTarget "3beta-sterols" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35350 ; owl:annotatedTarget "Hydroxysteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011417 ; owl:annotatedTarget "Increased length of the umbilical cord." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011417 ; owl:annotatedTarget "Long umbilical cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011419 ; owl:annotatedTarget "Separation of the placenta from the uterus wall before delivery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011420 ; owl:annotatedTarget "The age group when the cessation of life happens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011421 ; owl:annotatedTarget "Death during adolescence, the period between childhood and adulthood (roughly between the ages of 10 and 19 years)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011421 ; owl:annotatedTarget "Death in adolescence" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35350 ; owl:annotatedTarget "hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011422 ; owl:annotatedTarget "An abnormality of chloride homeostasis or concentration in the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011422 ; owl:annotatedTarget "Abnormal blood Cl concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011422 ; owl:annotatedTarget "Abnormal blood Cl- concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35350 ; owl:annotatedTarget "hydroxysteroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011423 ; owl:annotatedTarget "An abnormally increased chloride concentration in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35352 ; owl:annotatedTarget "organonitrogen compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011424 ; owl:annotatedTarget "An increased consentration of zinc in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35352 ; owl:annotatedTarget "organonitrogens" . [] oboInOwl:hasDbXref "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011425 ; owl:annotatedTarget "An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011425 ; owl:annotatedTarget "Foetal ultrasound soft marker" . [] oboInOwl:hasDbXref , "PMID:16100637", "PMID:16809660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011426 ; owl:annotatedTarget "Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (PMID:16100637)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011426 ; owl:annotatedTarget "Foetal choroid plexus cysts" . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011427 ; owl:annotatedTarget "The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vermis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (PMID:16100637)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011427 ; owl:annotatedTarget "Enlarged foetal cisterna magna" . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011428 ; owl:annotatedTarget "A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011428 ; owl:annotatedTarget "Short fetal thigh bone length" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011428 ; owl:annotatedTarget "Short foetal femur length" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011428 ; owl:annotatedTarget "Short foetal thigh bone length" . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011429 ; owl:annotatedTarget "A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011429 ; owl:annotatedTarget "Short fetal long bone in upper arm length" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011429 ; owl:annotatedTarget "Short foetal humerus length" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011429 ; owl:annotatedTarget "Short foetal long bone in upper arm length" . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011430 ; owl:annotatedTarget "On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (PMID:16100637)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011430 ; owl:annotatedTarget "Hypoplasia of foetal nasal bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011430 ; owl:annotatedTarget "Underdeveloped fetal nose bone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011430 ; owl:annotatedTarget "Underdeveloped foetal nose bone" . [] oboInOwl:hasDbXref , "PMID:16100637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (PMID:16100637)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Fetal little finger curvature" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:14499495" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "PMID:14287444" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Fetal pinkie finger curvature" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Fetal pinky finger curvature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Foetal little finger curvature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Foetal pinkie finger curvature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Foetal pinky finger curvature" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011431 ; owl:annotatedTarget "Foetal fifth finger clinodactyly" . [] oboInOwl:hasDbXref "PMID:32039804" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011432 ; owl:annotatedTarget "Increase in the levels of maternal serum alpha-fetoprotein levels during pregnancy." . [] oboInOwl:hasDbXref , "PMID:2447576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011433 ; owl:annotatedTarget "An abnormally high concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age." . [] oboInOwl:hasDbXref , "PMID:2447576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011434 ; owl:annotatedTarget "An abnormally low concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age." . [] oboInOwl:hasDbXref , "PMID:19038077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011435 ; owl:annotatedTarget "An abnormally low concentration of serum PAPP-A (pregnancy associated plasma protein A), as compared to normal values for gestational-age." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "PMID:14300208" . [] oboInOwl:hasDbXref , "PMID:19038077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011436 ; owl:annotatedTarget "An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011437 ; owl:annotatedTarget "A medical history of a fetus or child born to a mother with an autoimmune disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011438 ; owl:annotatedTarget "A medical history of exposure of the mother of a child or fetus to a teratogenic substance during pregnancy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011439 ; owl:annotatedTarget "Rhabdomyolysis induced by anesthesia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011440 ; owl:annotatedTarget "Rhabdomyolysis induced by intake of alcohol." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "PMID:14328676" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011441 ; owl:annotatedTarget "An abnormality of the medulla oblongata, the lower half of the brainstem." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011442 ; owl:annotatedTarget "An anomaly of the control or production of movement in the central nervous system." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "Fatty acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011443 ; owl:annotatedTarget "Abnormality of coordination" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011443 ; owl:annotatedTarget "Coordination issue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011444 ; owl:annotatedTarget "A type of rigidity in which the arms are in flexion and adduction and the legs are extended. This signifies a lesion in the cerebral white matter, internal capsules, or thalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011445 ; owl:annotatedTarget "A type of cerebral palsy characterized by slow, involuntary muscle movement and mixed muscle tone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011446 ; owl:annotatedTarget "Cognitive, psychiatric or memory anomaly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011447 ; owl:annotatedTarget "Hyposegmented (hypolobulated) or bilobed neutrophil nuclei." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011447 ; owl:annotatedTarget "Hyposegmentation of neutrophil nuclei in peripheral blood" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011448 ; owl:annotatedTarget "Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Ankle clonus is tested by rapidly flexing the foot upward." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011448 ; owl:annotatedTarget "Abnormal rhythmic movements of ankle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "Fettsaeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011449 ; owl:annotatedTarget "Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Knee clonus can be tested by rapidly pushing the patella towards the toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011450 ; owl:annotatedTarget "Central nervous system infection" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Head circumference below 2 standard deviations below the mean for age and gender at birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Congenital small head" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Congenital small head circumference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Small head circumference present at birth" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "Fettsaeuren" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Small head present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Small skull present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Congenital decreased head circumference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Congenital small skull" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Decreased head circumference present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Microcephaly present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Small cranium present at birth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011451 ; owl:annotatedTarget "Head circumference small for gestational age" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "acide gras" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011452 ; owl:annotatedTarget "An abnormality of the function of the middle ear." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011452 ; owl:annotatedTarget "Functional abnormality of the middle ear" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "acides gras" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011453 ; owl:annotatedTarget "An abnormality of the incus, an ossicle in the middle ear." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "acido graso" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011454 ; owl:annotatedTarget "An abnormality of the malleus, an ossicle in the middle ear." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:14535055" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "acidos grasos" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011455 ; owl:annotatedTarget "Aplasia of the malleus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011456 ; owl:annotatedTarget "Aplasia of the stapes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011457 ; owl:annotatedTarget "This term refers to the loss of eyelashes that were previously present." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35366 ; owl:annotatedTarget "fatty acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011457 ; owl:annotatedTarget "Eyelashes fell out" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011457 ; owl:annotatedTarget "Loss of eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011457 ; owl:annotatedTarget "Missing eyelashes" . [] oboInOwl:hasDbXref , "NCIT:C3513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011459 ; owl:annotatedTarget "The presence of a carcinoma of the esophagus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011460 ; owl:annotatedTarget "Onset of disease at up to 8 weeks following fertilization (corresponding to 10 weeks of gestation)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "Monosaccharide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011461 ; owl:annotatedTarget "Onset prior to birth but after 8 weeks of embryonic development (corresponding to a gestational age of 10 weeks)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011461 ; owl:annotatedTarget "Foetal onset" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011462 ; owl:annotatedTarget "Onset of disease at the age of between 16 and 40 years." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "monosaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011463 ; owl:annotatedTarget "Onset of disease at the age of between 1 and 5 years." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011463 ; owl:annotatedTarget "Symptoms begin in childhood" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011464 ; owl:annotatedTarget "A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the small intestine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011465 ; owl:annotatedTarget "A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the duodenum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "Monosaccharid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011466 ; owl:annotatedTarget "Absence or underdevelopment of the gallbladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011466 ; owl:annotatedTarget "Absent/small gallbladder" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011466 ; owl:annotatedTarget "Absent/underdeveloped gallbladder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "Monosacharid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011467 ; owl:annotatedTarget "A developmental defect in which the gallbladder fails to form." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011467 ; owl:annotatedTarget "Absent gallbladder" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Myoclonus of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Cramping of facial muscles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "monosacarido" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Facial spasms" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Facial tics" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Jerking of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Mimic spasms" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Spasms of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Twitching of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Involuntary facial muscle spasms" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011468 ; owl:annotatedTarget "Muscle spasm of face" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011469 ; owl:annotatedTarget "Regurgitation of milk through the nose." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011470 ; owl:annotatedTarget "Feeding problem necessitating nasogastric tube feeding." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35381 ; owl:annotatedTarget "monosacaridos" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011471 ; owl:annotatedTarget "Feeding problem necessitating gastrostomy tube feeding." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011472 ; owl:annotatedTarget "Abnormal shape of small intestinal villus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "The enteric villi are atrophic or absent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "Villous degeneration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "Biopsy shows villous atrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "Duodenal villous atrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "Small intestine biopsy shows villous atrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011473 ; owl:annotatedTarget "Variable degree of villous atrophy" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011474 ; owl:annotatedTarget "Sensorineural hearing impairment with childhood onset." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_mbitner-glidicz" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011475 ; owl:annotatedTarget "Persistence of the stapedial artery, which normally regresses during embryonic life." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dfitzpatrick" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011476 ; owl:annotatedTarget "Complete loss of hearing related to a sensorineural defect." . [] oboInOwl:hasDbXref , "PMID:21505601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011477 ; owl:annotatedTarget "In primary position, the eyes drift slowly downward and then spontaneously beat upward. Upward gaze accentuates the nystagmus. The associated oscillopsias are often very irritating, but the symptoms are usually transient." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011478 ; owl:annotatedTarget "Absence of globe, optic nerve, chiasm and optic tracts. No evidence of ocular tissue on MRI scan or examination." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011478 ; owl:annotatedTarget "Complete anophthalmia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011478 ; owl:annotatedTarget "Completely missing eyeball" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011478 ; owl:annotatedTarget "Total anophthalmia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:14703707" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011479 ; owl:annotatedTarget "An abnormality of the lacrimal punctum, an opening on the eyelid close to the medial canthus that drains tears from the conjunctival sac into the lacrimal duct in the same eyelid." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011480 ; owl:annotatedTarget "A developmental anomaly characterized by abnormal smallness of one eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011480 ; owl:annotatedTarget "Abnormally small eyeball on one side" . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35391 ; owl:annotatedTarget "aspartate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011480 ; owl:annotatedTarget "Unilateral nanophthalmos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011481 ; owl:annotatedTarget "An abnormality of the lacrimal duct, a duct that drain tears from the conjunctiva, via the lacrimal puncta, into the lacrimal sac." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35391 ; owl:annotatedTarget "hydrogen aspartate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011482 ; owl:annotatedTarget "Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011483 ; owl:annotatedTarget "Adhesions between the iris and the cornea." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011484 ; owl:annotatedTarget "Adhesions between the iris and the lens." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011485 ; owl:annotatedTarget "Developmental abnormality in which the lens and cornea are not separated." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35391 ; owl:annotatedTarget "2-ammoniobutanedioate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011486 ; owl:annotatedTarget "An abnormal anteroposterior thickness of the cornea." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35391 ; owl:annotatedTarget "2-ammoniosuccinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011487 ; owl:annotatedTarget "A increased anteroposterior thickness of the cornea." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35391 ; owl:annotatedTarget "aspartic acid monoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011488 ; owl:annotatedTarget "Abnormality of the corneal endothelium, that is, the single layer of cells on the inner surface of the cornea." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35406 ; owl:annotatedTarget "oxoanion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011489 ; owl:annotatedTarget "Abnormal migration of corneal endothelium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35406 ; owl:annotatedTarget "oxoacid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011490 ; owl:annotatedTarget "Abnormality of Descemet's membrane, which is the basement membrane of the corneal endothelium." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011491 ; owl:annotatedTarget "A reduction in the number of corneal endothelial cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35406 ; owl:annotatedTarget "oxoanions" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011492 ; owl:annotatedTarget "An abnormality of the stroma of cornea, also known as the substantia propria of cornea." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011493 ; owl:annotatedTarget "Reduced transparency of the central portion of the corneal stroma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011494 ; owl:annotatedTarget "Generalized reduced transparency of the stroma of the cornea." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011494 ; owl:annotatedTarget "Generalised opacification of the cornea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011495 ; owl:annotatedTarget "Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter", "PMID:22898649" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011496 ; owl:annotatedTarget "Ingrowth of new blood vessels into the cornea." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011496 ; owl:annotatedTarget "Corneal neovascularisation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011496 ; owl:annotatedTarget "New blood vessel formation in cornea" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011497 ; owl:annotatedTarget "New growth of vessels on the surface of the iris." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011497 ; owl:annotatedTarget "New blood vessel formation in iris" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011499 ; owl:annotatedTarget "Abnormal dilatation of the iris." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:15542928" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011499 ; owl:annotatedTarget "Dilated pupil" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011500 ; owl:annotatedTarget "Multiple pupils." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011500 ; owl:annotatedTarget "Multiple pupils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011501 ; owl:annotatedTarget "A conical projection of the anterior surface of the lens, occurring as a developmental anomaly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011502 ; owl:annotatedTarget "A conical projection of the posterior surface of the lens, occurring as a developmental anomaly." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35418 ; owl:annotatedTarget "Reaxys:9227329" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011503 ; owl:annotatedTarget "Congenital absence of the fovea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011503 ; owl:annotatedTarget "Absent fovea" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011504 ; owl:annotatedTarget "Progressive maculopathy characterized by concentric regions of hyper- and hypo-pigmentation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011504 ; owl:annotatedTarget "Chloroquine retinopathy" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011505 ; owl:annotatedTarget "Cystoid macular edema (CME) is any type of macular edema that involves cyst formation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011506 ; owl:annotatedTarget "Choroidal neovascularization (CNV) is the creation of new blood vessels in the choroid layer of the eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011507 ; owl:annotatedTarget "Pale often indistinct lesions of the macula." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35418 ; owl:annotatedTarget "5-acetamido-3,5-dideoxy-D-galacto-non-2-ulopyranosonate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011508 ; owl:annotatedTarget "A macular hole is a small break in the macula, located in the center of the retina." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35418 ; owl:annotatedTarget "N-acetylneuraminate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011509 ; owl:annotatedTarget "Increased amount of pigmentation in the macula lutea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011510 ; owl:annotatedTarget "Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye." . [] oboInOwl:hasDbXref "MetaCyc" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35418 ; owl:annotatedTarget "sialate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011511 ; owl:annotatedTarget "Splitting of the retina in the macular region." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35441 ; owl:annotatedTarget "anti-infective agents" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011512 ; owl:annotatedTarget "Increased pigmentation of the fundus" . [] oboInOwl:hasDbXref , "PMID:20844673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011513 ; owl:annotatedTarget "A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous angioma are described as having a 'cluster of grapes' appearance." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011514 ; owl:annotatedTarget "An abnormality of binocular vision, that is of the ability to synthesize the visual inputs from both eyes to a single image with perception of depth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011515 ; owl:annotatedTarget "Inability to make fine depth discriminations from parallax provided by the two eyes' different positions on the head." . [] oboInOwl:hasDbXref , "PMID:12015282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011516 ; owl:annotatedTarget "A condition where the retina contains no functional cone cells, so that in addition to the absence of color discrimination, vision in lights of normal intensity is difficult." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011517 ; owl:annotatedTarget "The condition of having both rods and cones, but only a single kind of cone. Affected individuals have good pattern vision in daylight, but cannot distinguish between colors." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011518 ; owl:annotatedTarget "Individuals affected by dichromacy possess only two types of cones, instead of three." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011519 ; owl:annotatedTarget "Individuals with anomalous trichromacy possess three types of cones, but one of the three types of cones has an abnormal spectral sensitivity compared to normal cones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35441 ; owl:annotatedTarget "anti-infective drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011520 ; owl:annotatedTarget "A type of anomalous trichromacy associated with abnormal M photopigment, such that the absorption spectrum is shifted toward L wavelengths. Affected individuals have difficulties distinguishing between red and green." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011520 ; owl:annotatedTarget "Green-weak" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011521 ; owl:annotatedTarget "Complete lack of the M photopigment, which is replaced with the L photopigment. Affected individuals tend to confuse red and green." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011521 ; owl:annotatedTarget "Green-blind" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011522 ; owl:annotatedTarget "Blue and green cones only; no functional red cones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011522 ; owl:annotatedTarget "Red-blind" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35441 ; owl:annotatedTarget "antiinfective agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011523 ; owl:annotatedTarget "An iris cyst is composed of a single cell layer of epithelium and is filled with fluid." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011524 ; owl:annotatedTarget "Malignant tumor of melanocytes affecting the iris." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011525 ; owl:annotatedTarget "A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35441 ; owl:annotatedTarget "antiinfective drug" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011525 ; owl:annotatedTarget "Eye freckle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011526 ; owl:annotatedTarget "An abnormal shape of the lens." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011526 ; owl:annotatedTarget "Abnormality of lens shape" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35469 ; owl:annotatedTarget "antidepressant drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011527 ; owl:annotatedTarget "Exaggerated curvature of the lens of the eye, producing an anterior or posterior spherical bulging." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011527 ; owl:annotatedTarget "Bulging of eye lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011528 ; owl:annotatedTarget "Sharply demarcated hyperpigmentation which is congenital found in around 3-5% of the population and of no functional significance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011529 ; owl:annotatedTarget "Sharply demarcated hyperpigmentation which is congenital." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011529 ; owl:annotatedTarget "Multiple bilateral CHRPE" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011530 ; owl:annotatedTarget "A small break in the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011530 ; owl:annotatedTarget "Retinal holes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011531 ; owl:annotatedTarget "Inflammation of the vitreous body, characterized by the presence of inflammatory cells and protein exudate in the vitreous cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011532 ; owl:annotatedTarget "A type of retinal exudate located in the subretinal space between the sensory retina and the retinal pigment epithelium." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_ncarter", "PMID:18179896" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011533 ; owl:annotatedTarget "The appearance of yellow/white crystalline-like (hence the name) spots in the retina and thickening of the peripheral part of the vitreous." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:15661432" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35469 ; owl:annotatedTarget "antidepressants" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011535 ; owl:annotatedTarget "Abnormality of the spatial relationship of the atria to other components of the heart." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011535 ; owl:annotatedTarget "Abnormal location of heart atrium" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:3408620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011536 ; owl:annotatedTarget "Right atrial isomerism is characterized by bilateral triangular, morphologically right atrial, appendages, both joining the atrial chamber along a broad front with internal terminal crest." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:3408620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011537 ; owl:annotatedTarget "In left atrial isomerism there is a bilateral small finger-shaped morphologically left atrial appendage joining the atrial chamber along a narrow front without an internal terminal crest." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011538 ; owl:annotatedTarget "Mirror image atrial arrangement, with morphologic right atrium on the left hand side and morphologic left atrium on the right hand side." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011539 ; owl:annotatedTarget "Common atrium without defining morphologic features." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011539 ; owl:annotatedTarget "Atrial heterotaxy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011539 ; owl:annotatedTarget "Atrial situs ambiguus" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:21569592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011540 ; owl:annotatedTarget "The essence of the lesion is the combination of discordant atrioventricular and ventriculo-arterial connections. Thus, the morphologically right atrium is connected to a morphologically left ventricle across the mitral valve, with the left ventricle then connected to the pulmonary trunk. The morphologically left atrium is connected to the morphologically right ventricle across the tricuspid valve, with the morphologically right ventricle connected to the aorta." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011541 ; owl:annotatedTarget "Crossing of the inflow streams of the two ventricles, due to an apparent twisting of the heart about its long axis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35469 ; owl:annotatedTarget "thymoanaleptics" . [] oboInOwl:hasDbXref "PMID:11789809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011542 ; owl:annotatedTarget "Criss-cross atrioventricular valves with a rare cardiac malformation characterized by the two ventricles lying one above the other instead of side by side." . [] oboInOwl:hasDbXref "PMID:24876921" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011545 ; owl:annotatedTarget "A deviance in the normal connections between two cardiac segements." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011545 ; owl:annotatedTarget "Abnormal connexion of the cardiac segments" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011546 ; owl:annotatedTarget "An abnormality of the circulatory connection between atria and ventricles." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011546 ; owl:annotatedTarget "Abnormal atrioventricular connexion" . [] oboInOwl:hasDbXref "PMID:7104116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011547 ; owl:annotatedTarget "A defect where there is no connection between the left atrium and left ventricle." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011547 ; owl:annotatedTarget "Absent left sided atrioventricular connexion" . [] oboInOwl:hasDbXref "PMID:7104116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011548 ; owl:annotatedTarget "A defect where there is no connection between the right atrium and right ventricle." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011548 ; owl:annotatedTarget "Absent right sided atrioventricular connexion" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011549 ; owl:annotatedTarget "Univentricular heart with absent left sided atrioventricular connexion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35469 ; owl:annotatedTarget "thymoleptic drugs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011551 ; owl:annotatedTarget "Right sided atrium to left ventricle and absent left sided atrioventricular connexion" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011552 ; owl:annotatedTarget "With left or right cardiac isomerism in a biventricular, the atrioventricular connections are perforce ambiguous, in that one of the connections is concordant (e.g., right-sided morphologic right atrium connected to a morphologic right ventricle) and one of the connections is discordant (e.g., left-sided morphologic right atrium connected to a morphologic left ventricle)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011552 ; owl:annotatedTarget "Ambiguous atrioventricular connexion" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:23804932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011553 ; owl:annotatedTarget "Connection of the right atrium to the left ventricle and of the left atrium to the right ventricle in a biventricular heart." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011553 ; owl:annotatedTarget "Discordant atrioventricular connexion" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011554 ; owl:annotatedTarget "The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011554 ; owl:annotatedTarget "Double inlet atrioventricular connexion" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011555 ; owl:annotatedTarget "The condition in which both atria are joined to the left ventricle each by its own atrioventricular valve. Usually there is a hypoplastic right ventricle, which may be on the opposite side of the heart as usual." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011556 ; owl:annotatedTarget "The condition in which both atria are joined to the right ventricle each by its own atrioventricular valve. Usually, the left ventricle is hypoplastic." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011557 ; owl:annotatedTarget "The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve. The morphology of this ventricle does not allow one to determine if it corresponds to the left or right ventricle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35469 ; owl:annotatedTarget "thymoleptics" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011560 ; owl:annotatedTarget "A congenital defect with failure to open of the mitral valve orifice." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:7295418" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011561 ; owl:annotatedTarget "An atrioventricular valve that empties into both ventricles. The valve overrides the interventricular septum above a ventricular septum defect." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:7295418" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011562 ; owl:annotatedTarget "Anomalous insertion of the chordae tendinae or papillary muscles into the contralateral ventricle in the presence of a ventricular septum defect." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35470 ; owl:annotatedTarget "CNS agent" . [] oboInOwl:hasDbXref "PMID:15227248", "PMID:18805185", "PMID:24750982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011563 ; owl:annotatedTarget "An abnormality of the circulatory connection between the ventricles and the pulmonary artery and aorta." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011563 ; owl:annotatedTarget "Abnormal ventriculoarterial connexion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:20404264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011564 ; owl:annotatedTarget "Anomalous mitral valve arcade is diagnosed based on the following features (1) An adequately sized mitral valve orifice; (2) short, thick, and poorly differentiated chordae with direct union of the papillary muscles to the anterior leaflet; (3) narrow or nearly nonexistent spaces between the abnormal chordae; and (4) greater differentiation of the chordae attached to the posterior papillary muscle." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011565 ; owl:annotatedTarget "Complete absence of the interatrial septum with common atrioventricular valve and two atrioventricular connections." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011565 ; owl:annotatedTarget "Single atrium" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:17948095" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011566 ; owl:annotatedTarget "A congenital anomaly with partitioning of the right atrium to form a triatrial heart caused by persistence of the right valve of the sinus venosus. Typically, the right atrial partition is due to exaggerated fetal eustachian and thebesian valves, which together form an incomplete septum across the lower part of the atrium. This septum may range from a reticulum to a substantial sheet of tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011566 ; owl:annotatedTarget "Cor triatriatum dextrum" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:16172274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011567 ; owl:annotatedTarget "An interatrial communication caused by a deficiency of the common wall between the superior vena cava (SVC) and the right-sided pulmonary veins. SVASD is commonly associated with anomalous pulmonary venous connection (APVC) of some or all of the pulmonary veins, which produces additional left-to-right shunting." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:20851840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011568 ; owl:annotatedTarget "The left atrio-ventricular connection consists of two anatomically distinct orifices separated by accessory fibrous tissue." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:6829465" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011569 ; owl:annotatedTarget "Cleft in the anterior mitral valve leaflet not associated with an atrioventricular canal defect." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35470 ; owl:annotatedTarget "CNS drugs" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011570 ; owl:annotatedTarget "Mitral stenosis with congenital onset." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011571 ; owl:annotatedTarget "Abnormality of the mitral valve apparatus, whereby chordae attach to a single papillary muscle or hypoplastic papillary muscles." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011572 ; owl:annotatedTarget "A congenital stenotic mitral valvular anomaly with a ring of tissue above the mitral valve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35470 ; owl:annotatedTarget "central nervous system agents" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011573 ; owl:annotatedTarget "Congenital defect characterized by underdevelopment of the tricuspid valve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011573 ; owl:annotatedTarget "Underdeveloped tricuspid valve" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011574 ; owl:annotatedTarget "An atrioventricular valve that has failed to open (atretic)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35471 ; owl:annotatedTarget "psychoactive agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011574 ; owl:annotatedTarget "Unopened atrioventricular valve" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:7066117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011575 ; owl:annotatedTarget "A tricuspid valve that has failed to open." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011575 ; owl:annotatedTarget "Unopened tricuspid valve" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35471 ; owl:annotatedTarget "psychoactive drugs" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011576 ; owl:annotatedTarget "A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and inlet ventricular defect. There is one valve annulus and two valve orifices." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011577 ; owl:annotatedTarget "A specific combination of heart defects including a primum atrial septal defect and cleft anterior mitral valve leaflet. There is not an inlet ventricular septal defect present. There are two valve annuluses and two valve orifices." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011578 ; owl:annotatedTarget "A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and an inlet ventricular septal defect. There are two valve annuli and two valve orifices." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:20837915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011579 ; owl:annotatedTarget "Anatomic features of unbalanced atrioventricular septal defect (AVSD) include varying amounts of ventricular hypoplasia, as well as malalignment of the atrioventricular junction. In complete AVSD, the common AV valve can be situated either equally over the right and left ventricles (balanced) or unequally over the ventricles (unbalanced)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35471 ; owl:annotatedTarget "psychopharmaceuticals" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011580 ; owl:annotatedTarget "Abnormally short chordae tendineae of the mitral valve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011581 ; owl:annotatedTarget "A congenital defect of heart development characterized by origin of both pulmonary artery and aorta from the morphological left ventricle." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011582 ; owl:annotatedTarget "Displacement of the heart outside the thoracic cavity and into the abdomen." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011583 ; owl:annotatedTarget "A type of ectopia cordis with the heart partially in the cervical region and without a defect of the sternum." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011584 ; owl:annotatedTarget "A type of ectopia cordis with the heart partially in the cervical region with a defect of the superior portion of the sternum." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011585 ; owl:annotatedTarget "Congenital malformation of the thoracic wall with partial or total displacement of the heart outside the thoracic cavity. This feature is associated with sternal cleft or absence of the sternum." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:19479716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011586 ; owl:annotatedTarget "Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and displacement partially into the abdominal cavity." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011587 ; owl:annotatedTarget "A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011588 ; owl:annotatedTarget "The aortic arch extends into the soft tissues of the neck before turning down into to become the descending aorta." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:16405508" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35471 ; owl:annotatedTarget "psychotropic drugs" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:17138027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011589 ; owl:annotatedTarget "The left common carotid artery has a common origin with the innominate artery." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:15148283", "PMID:15564538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011590 ; owl:annotatedTarget "A conenital abnormality of the aortic arch in which the two embryonic aortc arches form a vascular ring that surrounds the trachea or esophagus and then join to form the descending aorta. Double aortic arch can cause symptoms because of compression of the esophagus (dysphagia, cyanosis while eating) or trachea (stridor)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011592 ; owl:annotatedTarget "The subclavian artery arises from ductus arteriosus. While the ductus arteriosus is patent its blood supply comes from the ductus, hence from the pulmonary artery. After it closes, the blood supply is retrogradely from the vertebral artery via the circle of Willis." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011593 ; owl:annotatedTarget "A patent ductus arteriosus or ductal ligament completes the ring." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:12075866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011594 ; owl:annotatedTarget "Aortic arch crosses the right mainstem bronchus. The left carotid artery is the first branch, right carotid artery the second branch and right subclavian artery as the third branch." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011595 ; owl:annotatedTarget "Aortic arch crosses the left mainstem bronchus. The first branch is the right carotid artery, the second branch is the left carotid artery, the third branch is the subclavian artery, the fourth branch is the right subclavian artery arising from the posteromedial aspect of the distal aortic arch and continuing posterior to the esophagus to the right hand side of the body." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011596 ; owl:annotatedTarget "The ring may be completed by the ductal ligament." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011599 ; owl:annotatedTarget "Mesocardia is an abnormal location of the heart in which the heart is in a midline position and the longitudinal axis of the heart lies in the mid-sagittal plane." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011600 ; owl:annotatedTarget "Abnormal plane of direction of the heart from the base to the apex. Left sided is normal." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011601 ; owl:annotatedTarget "Abnormal plane of direction of the heart from the base to the apex towards the right. Left sided is normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35472 ; owl:annotatedTarget "anti-inflammatory drugs" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011602 ; owl:annotatedTarget "Abnormal plane of direction of the heart from the base to the apex in the midline. Left sided is normal." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011604 ; owl:annotatedTarget "A congenital anomaly with an abnormal connection between the aorta and the main pulmonary artery resulting in an aortopulmonary shunt." . [] oboInOwl:hasDbXref "PMID:21569592", "PMID:27777298", "PMID:32274202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011605 ; owl:annotatedTarget "A congenitally corrected transposition of the great arteries with a ventricular septal defect: a hole between the two bottom chambers (ventricles) of the heart. The ventricular septal defect is centered around the most superior aspect of the ventricular septum." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011605 ; owl:annotatedTarget "CCTGA" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011605 ; owl:annotatedTarget "ccTGA" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011608 ; owl:annotatedTarget "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with each pulmonary artery arising separate from each other on the posterior or lateral aspect of the truncus." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011609 ; owl:annotatedTarget "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby one of the two pulmonary artery branched does not arise from the common pulmonary trunk, but instead from the ductus arteriosus or directly from the aorta." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011610 ; owl:annotatedTarget "Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby the aortic arch is hypoplastic or interrupted, and a large patent ductus arteriosus is present." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011611 ; owl:annotatedTarget "Non-continuity of the arch of aorta with an atretic point or absent segment." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011612 ; owl:annotatedTarget "Non-continuity of the aortic arch with an atretic point or absent segment at the level of the isthmus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35472 ; owl:annotatedTarget "antiinflammatory agent" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011613 ; owl:annotatedTarget "Non-continuity of the aortic arch with an atretic point or absent segment between the left carotid and subclavian arteries." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011614 ; owl:annotatedTarget "Non-continuity of the aortic arch with an atretic point or absent segment between the innominate and left carotid arteries." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011615 ; owl:annotatedTarget "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35472 ; owl:annotatedTarget "antiinflammatory drug" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011616 ; owl:annotatedTarget "Mirror image arrangement of the mainstem bronchi with the right pulmonary artery posterior to the right upper lobe bronchus and the left pulmonary artery anterior to the left upper lobe bronchus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011617 ; owl:annotatedTarget "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which the morphology of both left and right lungs is the same." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011618 ; owl:annotatedTarget "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a right lung." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011619 ; owl:annotatedTarget "An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a left lung." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011620 ; owl:annotatedTarget "An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:19561249" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011621 ; owl:annotatedTarget "A type of ventricular septal defect communicating directly between the left ventricle and right atrium. This is anatomically possible because the normal tricuspid valve is more apically displaced than the mitral valve." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:17101870" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011622 ; owl:annotatedTarget "A ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:17101870" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011623 ; owl:annotatedTarget "The trabecular septum is the largest part of the interventricular septum. It extends from the membranous septum to the apex and superiorly to the infundibular septum. A defect in the trabecular septum is called muscular VSD if the defect is completely rimmed by muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011623 ; owl:annotatedTarget "Ventricular septal defect, muscular" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011624 ; owl:annotatedTarget "A muscular ventricular septal defect located at the apex of the heart." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35472 ; owl:annotatedTarget "antiinflammatory drugs" . [] oboInOwl:hasDbXref "PMID:22718060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011625 ; owl:annotatedTarget "A type of muscular ventricular septal defect characterized by the presence of multiple small defects in the ventricular septum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:16638549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011626 ; owl:annotatedTarget "Right pulmonary venous return to the inferior vena cava." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011626 ; owl:annotatedTarget "Pulmonary venolobar syndrome" . [] oboInOwl:hasDbXref "PMID:17922908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011627 ; owl:annotatedTarget "Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinotubular junction to the cavity of the left, or (less commonly) right ventricle." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011628 ; owl:annotatedTarget "A developmental defect of the pericardium with congenital onset." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35479 ; owl:annotatedTarget "alkali metal salts" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011629 ; owl:annotatedTarget "No pericardium around the heart, occurring as a congenital defect, not the result of a surgical pericardectomy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011629 ; owl:annotatedTarget "Absent pericardium" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011629 ; owl:annotatedTarget "Congenital absence of the pericardium" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011630 ; owl:annotatedTarget "No pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011631 ; owl:annotatedTarget "No pericardium is present on the righthand side of the heart. It is a congenital absence of pericardium rather than the result of a pericardectomy." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011632 ; owl:annotatedTarget "A congenital anomaly with lack of part of the pericardium on the righthand side of the heart." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011633 ; owl:annotatedTarget "A congenital anomaly with complete lack of the pericardium on the lefthand side of the heart." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011633 ; owl:annotatedTarget "Absent lining around of left side of heart" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35488 ; owl:annotatedTarget "CNS depressants" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011634 ; owl:annotatedTarget "A congenital anomaly with lack of part of the pericardium on the lefthand side of the heart." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011635 ; owl:annotatedTarget "Lack of a part of the pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011636 ; owl:annotatedTarget "Isolated abnormalities of the coronary artery origins. This may be in associated with other structural heart malformations but not the patterns of complex structural heart malformations which result in abnormal course of the coronary arteries." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011637 ; owl:annotatedTarget "A coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:27358682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011638 ; owl:annotatedTarget "Left main coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the left cusp of the aortic valve." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011638 ; owl:annotatedTarget "ALCAPA" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011639 ; owl:annotatedTarget "Right coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the right cusp of the aortic valve." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:4547578" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011640 ; owl:annotatedTarget "The presence of a single coronary artery ostium from which both coronary arteries arise." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:20513726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011641 ; owl:annotatedTarget "A congenital malformation with abnormal connection between one of the coronary arteries and a heart chamber or another blood vessel." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011641 ; owl:annotatedTarget "Coronary fistula" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35488 ; owl:annotatedTarget "central nervous system depressants" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011642 ; owl:annotatedTarget "An abnormality of the coronary sinus, which is formed by the union of the great cardiac vein and the left marginal vein and terminates in the right atrium. The coronary sinus functions to o collect deoxygenated blood from the myocardium of the heart and drain it into the right atrium." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:18806021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011643 ; owl:annotatedTarget "An atrial septal defect characterized by a deficiency in the tissue separating the coronary sinus from the left atrium (LA). This results in partial or complete unroofing of the coronary sinus leading to a predominantly left-to-right shunt through the coronary sinus (LA to coronary sinus to right atrium [RA]). The orifice of the ostium is frequently large because of the increased flow. From the RA side, the defect is located at the level of the coronary sinus ostium and may also include some deficiency in atrial tissue around the ostium. From the LA side, the size can be variable depending on the degree of unroofing of the coronary sinus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:3138904" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011644 ; owl:annotatedTarget "A venous pouch within the left ventricular wall, with a neck opening into the coronary sinus." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35489 ; owl:annotatedTarget "disulfides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011645 ; owl:annotatedTarget "Aneurysm of the aortic sinus" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011646 ; owl:annotatedTarget "Narrowing or constriction of the aorta localized at the insertion of the ductus arteriosus, i.e., to the juxtaductal region of aortic arch." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011647 ; owl:annotatedTarget "Narrowing or constriction of the aorta localized distal to the ductus arteriosus, i.e., to the postductal region of aortic arch." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35489 ; owl:annotatedTarget "an organic disulfide" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011648 ; owl:annotatedTarget "Abnormal persistent patency of the ductus arteriosus in postnatal life when birth was at 37 completed weeks of gestation or greater." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011649 ; owl:annotatedTarget "Abnormal persistent patency of the ductus arteriosus when birth was at less than 37 weeks completed gestation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011650 ; owl:annotatedTarget "The presence of both a left and a right ductus arteriosus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011650 ; owl:annotatedTarget "Bilateral ductus botalli" . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011651 ; owl:annotatedTarget "A double outlet right ventricle with a subaortic ventricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011651 ; owl:annotatedTarget "DORV with doubly committed VSD and pulmonary stenosis" . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011652 ; owl:annotatedTarget "A double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:10798433" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011652 ; owl:annotatedTarget "DORV with doubly committed VSD" . [] oboInOwl:hasDbXref "PMID:10431853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011653 ; owl:annotatedTarget "A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, and also has a pulmonary stenosis; abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:10431853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011654 ; owl:annotatedTarget "A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, but there is not accompanying pulmonary stenosis; the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:16787416" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35489 ; owl:annotatedTarget "organic disulfides" . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011655 ; owl:annotatedTarget "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011656 ; owl:annotatedTarget "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011657 ; owl:annotatedTarget "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasDbXref "PMID:20069085", "PMID:6193702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011658 ; owl:annotatedTarget "A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011658 ; owl:annotatedTarget "DORV with subpulmonary VSD without pulmonary stenosis" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011659 ; owl:annotatedTarget "Features of tetralogy of Fallot with either rudimentary ridges or the complete absence of pulmonic valve tissue." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:2590592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011660 ; owl:annotatedTarget "Anomalous origin of one pulmonary artery from the ascending aorta with the contralateral pulmonary artery arising from the right ventricle." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011661 ; owl:annotatedTarget "The left pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011662 ; owl:annotatedTarget "Failure to develop of the tricuspid valve and thus lack of the normal connection between the right atrium and the right ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011662 ; owl:annotatedTarget "Tricuspid valve atresia" . [] oboInOwl:hasDbXref , "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011663 ; owl:annotatedTarget "Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011663 ; owl:annotatedTarget "Cardiomyopathy, right ventricular" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011663 ; owl:annotatedTarget "Cardiomyopathy, esp. right ventricular" . [] oboInOwl:hasDbXref "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011664 ; owl:annotatedTarget "Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates." . [] oboInOwl:hasDbXref "PMID:17916581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011665 ; owl:annotatedTarget "Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011665 ; owl:annotatedTarget "Broken-heart syndrome" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:17578953", "PMID:19808620", "PMID:20532458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011666 ; owl:annotatedTarget "Absence of the right superior vena cava (RSVC). An absent RSVC is always associated with a persistent left superior vena cava (PLSVC). During normal fetal development, the left-sided anterior venous cardinal system regresses, leaving the coronary sinus (CS) and the ligament of Marshall. Failure of the closure of the left anterior cardinal vein results in PLSVC. In general, PLSVC is associated with the right superior vena cava (RSVC) and drains into the RA via a dilated CS. When developmental arrest occurs at an earlier stage, the CS is absent and the PLSVC drains into the left atrium." . [] oboInOwl:hasDbXref "PMID:18847480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011669 ; owl:annotatedTarget "A persistent left superior vena cava (PLSVC) that drains into the left atrium instead of the right atrium via the coronary sinus, resulting in a right to left sided shunt." . [] oboInOwl:hasDbXref "PMID:18847480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011670 ; owl:annotatedTarget "A persistent left superior vena cava (PLSVC) that drains into the right atrium via the coronary sinus. This is the case in 80-92% of cases of PLSVC and results in no hemodynamic consequence." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:10550884" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011671 ; owl:annotatedTarget "Interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava." . [] oboInOwl:hasDbXref , "PMID:7477198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011672 ; owl:annotatedTarget "A myxoma (tumor of primitive connective tissue) of the heart. Cardiac myxomas consist of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma. Cardiac myxomas are of endocardial origin and general project from the endocardium into a cardiac chamber." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011673 ; owl:annotatedTarget "Abnormal proliferation of blood vessels within the cardiac cavities attached to the endocardium." . [] oboInOwl:hasDbXref , "PMID:17331235" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011674 ; owl:annotatedTarget "A teratoma within the heart. Most commonly, these tumors are detected in the pericardial cavity attached to the pulmonary artery and aorta. The tumor size within the heart varies from 2 to 9 cm in diameter, and intrapericardial tumors as large as 15 cm have been reported. Intracardiac tumors arise from the atrial or ventricular wall as nodular masses protruding into the cardiac chambers. Cardiac and pericardial teratomas are easily detected in the fetus and neonate by two-dimensional echocardiography as heterogeneous and encapsulated cystic masses. Histologically, cardiac teratomas contain multiple immature elements including epithelium, neuroglial tissue, thyroid, pancreas, smooth and skeletal muscle, cartilage and bone." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:19063792" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011675 ; owl:annotatedTarget "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011675 ; owl:annotatedTarget "Abnormal heart rate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011675 ; owl:annotatedTarget "Heart rhythm disorders" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35492 ; owl:annotatedTarget "Gmelin:51007" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011675 ; owl:annotatedTarget "Irregular heart beat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011675 ; owl:annotatedTarget "Irregular heartbeat" . [] oboInOwl:hasDbXref , "PMID:22368654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011678 ; owl:annotatedTarget "A type of tetralogy of Fallot with pulmonary atresia in which all pulmonary blood flow is derived from major aortopulmonary collateral arteries (MAPCA)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011679 ; owl:annotatedTarget "The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:10798413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011681 ; owl:annotatedTarget "A ventricular septal defect that lies beneath the semilunar valve(s) in the conal or outlet septum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:10798413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011682 ; owl:annotatedTarget "A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011682 ; owl:annotatedTarget "Perimembraneous ventricular septal defect" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011682 ; owl:annotatedTarget "Ventricular septal defect, perimembranous" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:10798413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011683 ; owl:annotatedTarget "Any ventricular septal defect (VSD) that is small enough to restrict flow across it such that a pressure gradient exists between the two sides of the VSD." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011684 ; owl:annotatedTarget "Any ventricular septal defect (VSD) that does not restrict flow across it sufficiently to generate a pressure gradient between the two sides of the VSD." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35492 ; owl:annotatedTarget "3,3'-disulfanediylbis(2-ammoniopropanoate)" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011685 ; owl:annotatedTarget "The superior vena cava passes below the aortic arch." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011686 ; owl:annotatedTarget "An abnormal path of a coronary artery." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown", "PMID:20733110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011687 ; owl:annotatedTarget "A type of supraventricular tachycardia that originates in the atrioventricular node." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011687 ; owl:annotatedTarget "AV nodal tachycardia" . [] oboInOwl:hasDbXref "PMID:22459483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011688 ; owl:annotatedTarget "Supraventricular tachycardia in which an accessory pathway connecting the atria and ventricles, apart from the AV node, participates as a necessary part of a reentrant mechanism." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011688 ; owl:annotatedTarget "Supraventricular tachycardia with an accessory connexion mediated pathway" . [] oboInOwl:hasDbXref "PMID:22459483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011689 ; owl:annotatedTarget "Supraventricular tachycardia with an accessory connection mediated pathway that is called concealed becasue it is not seen on the ECG during sinus rhythm." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011689 ; owl:annotatedTarget "Supraventricular tachycardia with a concealed accessory connexion" . [] oboInOwl:hasDbXref "PMID:15831598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011690 ; owl:annotatedTarget "An incessant orthodromic tachycardia with anterograde conduction over the atrioventricular node and by retrograde conduction via an accessory pathway usually located in the posteroseptal region with slow and decremental conduction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011695 ; owl:annotatedTarget "Hemorrhage into the parenchyma of the cerebellum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35492 ; owl:annotatedTarget "3,3'-dithiobis(2-ammoniopropanoate)" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011695 ; owl:annotatedTarget "Cerebellar haemorrhage" . [] oboInOwl:hasDbXref "PMID:4019927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011700 ; owl:annotatedTarget "Chronic supraventricular tachycardia predominantly seen in childhood." . [] oboInOwl:hasDbXref "ORPHA:3282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011701 ; owl:annotatedTarget "Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic." . [] oboInOwl:hasDbXref "ORPHA:3282", "PMID:5451226" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011701 ; owl:annotatedTarget "Chaotic atrial tachycardia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011702 ; owl:annotatedTarget "An abnormality of the sinoatrial (SA) node in the right atrium. THe SA node acts as the pacemaker of the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011703 ; owl:annotatedTarget "Sinus tach" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011703 ; owl:annotatedTarget "Sinus tachy" . [] oboInOwl:hasDbXref "PMID:17420362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011704 ; owl:annotatedTarget "An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011705 ; owl:annotatedTarget "Delay of conduction through the atrioventricular node, which is manifested as prolongation of the PR interval in the electrocardiogram (EKG). All atrial impulses reach the ventricles." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011706 ; owl:annotatedTarget "An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35507 ; owl:annotatedTarget "natural product fundamental parents" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011707 ; owl:annotatedTarget "Progressive PR interval prolongation with the subsequent occurrence of a single nonconducted P wave that results in a pause. The pause that follows the nonconducted impulse is less than fully compensatory (less than the sum of two normal sinus intervals)." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011708 ; owl:annotatedTarget "A type of second degree atrioventricular (AV) block characterized by sudden failure to conduct an impulse through the AV node without a preceding change in the PR interval." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011709 ; owl:annotatedTarget "Atrioventricular (AV) dissociation is present if the atria and the ventricles are under the control of two separate pacemakers. AV dissociation can occur in the absence of a primary AV conduction disturbance." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011710 ; owl:annotatedTarget "Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011711 ; owl:annotatedTarget "Conduction block in the anterior division of the left bundle branch of the bundle of His." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011712 ; owl:annotatedTarget "A conduction block of the right branch of the bundle of His. This manifests as a prolongation of the QRS complex (greater than 0.12 s) with delayed activation of the right ventricle and terminal delay on the EKG." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011713 ; owl:annotatedTarget "A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG." . [] oboInOwl:hasDbXref "PMID:18421506" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011714 ; owl:annotatedTarget "Libman-Sacks valvular lesions are sterile fibrofibrinous vegetations that favor the left-sided heart valves and usually form on the ventricular surface of the mitral valve." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011715 ; owl:annotatedTarget "Abnormal conduction in all three divisions of the intraventricular conducting tissue." . [] oboInOwl:hasDbXref "PMID:22826742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011716 ; owl:annotatedTarget "Junctional ectopic tachycardia (JET) is a unique type of supraventricular arrhythmia defined by narrow QRS complex and atrioventricular (AV) dissociation or retrograde atrial conduction in a 1:1 pattern." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35508 ; owl:annotatedTarget "steroid fundamental parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011718 ; owl:annotatedTarget "An abnormality of the pulmonary veins." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011718 ; owl:annotatedTarget "Abnormality of lung veins" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011719 ; owl:annotatedTarget "Type 1 total anomalous pulmonary venous connection." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35509 ; owl:annotatedTarget "Beilstein:5247532" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011719 ; owl:annotatedTarget "Supracardiac total anomalous pulmonary venous connexion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011720 ; owl:annotatedTarget "Type 2 total anomalous pulmonary venous connection." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011720 ; owl:annotatedTarget "Cardiac total anomalous pulmonary venous connexion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011721 ; owl:annotatedTarget "Type 3 total anomalous pulmonary venous connection." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011721 ; owl:annotatedTarget "Infracardiac total anomalous pulmonary venous connexion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011722 ; owl:annotatedTarget "Type 4 total anomalous pulmonary venous connection." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011722 ; owl:annotatedTarget "Mixed total anomalous pulmonary venous connexion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011722 ; owl:annotatedTarget "Type 4 total anomalous pulmonary venous connection" . [] oboInOwl:hasDbXref "PMID:10859296", "PMID:16322929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011724 ; owl:annotatedTarget "Uhl anomaly of the right ventricle refers to the almost complete absence of right ventricular myocardium, normal tricuspid valve, and preserved septal and left ventricular myocardium." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_dbrown" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011726 ; owl:annotatedTarget "Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:16978535" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35509 ; owl:annotatedTarget "CAS:24887-75-0" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011726 ; owl:annotatedTarget "Persistent foetal circulation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011727 ; owl:annotatedTarget "Weakness of the peroneal muscles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011727 ; owl:annotatedTarget "Fibularis muscle weakness" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35509 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST02020000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011728 ; owl:annotatedTarget "Clonus at the elbow joint, i.e., an exaggerated phasic stretch reflex characterized by repetitive, rhythmic contractions at the elbow, generated by rapid passive stretch at the elbow joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011729 ; owl:annotatedTarget "An abnormality in the range and ease of motion of joints across their normal range." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011730 ; owl:annotatedTarget "An abnormality of sensation related to CNS function. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function may indicate a lesion of a parietal cortex, the thalamocortical projections to the parietal cortex, or the spinal cord." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35509 ; owl:annotatedTarget "androstane" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35516 ; owl:annotatedTarget "Beilstein:5334741" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011731 ; owl:annotatedTarget "An abnormality of the concentration of cortisol in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011732 ; owl:annotatedTarget "Any structural anomaly of the adrenal glands." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35516 ; owl:annotatedTarget "CAS:14982-53-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011733 ; owl:annotatedTarget "A functional abnormality of the adrenal glands." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011734 ; owl:annotatedTarget "A form of adrenal insufficiency related to a lack of ACTH, which leads to a decrease in the production of cortisol by the adrenal glands. Aldosterone production is not usually affected." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011735 ; owl:annotatedTarget "Adrenal insufficiency secondary to a defect in ACTH production." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35516 ; owl:annotatedTarget "CAS:14982-53-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011736 ; owl:annotatedTarget "A form of hyperaldosteronism caused by a defect within the adrenal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011737 ; owl:annotatedTarget "Adrenal insufficiency secondary to a defect in corticotropin-releasing hormone production." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011738 ; owl:annotatedTarget "Adrenal insufficiency secondary to a defect in the corticotropin-releasing hormone receptor." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011739 ; owl:annotatedTarget "A form of primary hyperaldosteronism in which the overproduction of aldosterone can be suppressed by the administration of dexamethasone." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011740 ; owl:annotatedTarget "A form of primary hyperaldosteronism in which the overproduction of aldosterone cannot be suppressed by the administration of dexamethasone or similar glucocorticoids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011741 ; owl:annotatedTarget "A form of hyperaldosteronism caused by abnormally increased renin levels." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35516 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST01010000" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011742 ; owl:annotatedTarget "Abnormal anatomical location of the adrenal gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011742 ; owl:annotatedTarget "Abnormal adrenal gland position" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35516 ; owl:annotatedTarget "cholestane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011743 ; owl:annotatedTarget "Absent development of the adrenal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011744 ; owl:annotatedTarget "Hypercortisolemia associated with a overproduction of ACTH (often from a tumor), leading secondarily to overproduction of cortisol." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011745 ; owl:annotatedTarget "An hormonally inactive adrenocortical adenoma, that is, an adenoma that does not secrete excessive amounts of adrenal hormones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011746 ; owl:annotatedTarget "An hormonally active adrenocortical adenoma, that is, an adenoma that secretes excessive amounts of adrenal hormones." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35519 ; owl:annotatedTarget "cholane" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011747 ; owl:annotatedTarget "An abnormality of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011748 ; owl:annotatedTarget "A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011749 ; owl:annotatedTarget "Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011750 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011750 ; owl:annotatedTarget "Neoplasm of the adenohypophysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011750 ; owl:annotatedTarget "Neoplasm of the pars anterior" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35522 ; owl:annotatedTarget "beta-adrenergic agonists" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011751 ; owl:annotatedTarget "An abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011751 ; owl:annotatedTarget "Abnormality of the neurohypophysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011752 ; owl:annotatedTarget "The presence of a neoplasm (tumor) in the neurohypophysis, which is also known as the posterior lobe of the hypophysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011752 ; owl:annotatedTarget "Neoplasm of the neurohypophysis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:20671299" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35522 ; owl:annotatedTarget "beta-adrenergic receptor agonist" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011753 ; owl:annotatedTarget "Abnormal development of the neurohypophysis during embryonic growth and development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011753 ; owl:annotatedTarget "Neurohypophysis dysplasia" . [] oboInOwl:hasDbXref , "PMID:17618441", "PMID:19109577" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011754 ; owl:annotatedTarget "A solid, low grade, spindle cell, glial neoplasm of adults that originates in the neurohypophysis or infundibulum. Clinical signs and symptoms include visual disturbance, headache and features of hypopituitarism. Pituicytomas are well-circumscribed, solid masses that can measure up to several centimeters. Histologically, they show a compact architecture consisting of elongate, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern." . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35522 ; owl:annotatedTarget "beta-adrenoceptor agonists" . [] a owl:Axiom ; rdfs:label "Pituicytoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0011754 ; owl:annotatedTarget "ICD-O:9432/1" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011755 ; owl:annotatedTarget "An abnormal anatomical location of the posterior lobe of the hypophysis, also known as the neurohypophysis. The posterior pituitary is normally present in the dorsal portion of the sella turcica, but when ectopic is usually near the median eminence. This defect is likely to be due to abnormal migration during embryogenesis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011755 ; owl:annotatedTarget "Ectopic neurohypophysis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35523 ; owl:annotatedTarget "bronchodilator" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011756 ; owl:annotatedTarget "Absence of the neurohypophysis owing to a developmental defect." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011756 ; owl:annotatedTarget "Neurohypophysis agenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35523 ; owl:annotatedTarget "bronchodilator agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011757 ; owl:annotatedTarget "Underdevelopment of the neurohypophysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011757 ; owl:annotatedTarget "Neurohypophysis hypoplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011759 ; owl:annotatedTarget "A type of pituitary adenoma that produces gonadotropins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011760 ; owl:annotatedTarget "A type of pituitary adenoma that produces growth hormone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35523 ; owl:annotatedTarget "broncholytic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011761 ; owl:annotatedTarget "A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011762 ; owl:annotatedTarget "A type of pituitary adenoma that produces thyroid stimulating hormone (TSH)." . [] oboInOwl:hasDbXref , "NCIT:C4536", "PMID:15741248" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011763 ; owl:annotatedTarget "A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS." . [] oboInOwl:hasDbXref , "PMID:21886889" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011764 ; owl:annotatedTarget "A spindled-to-epithelioid, oncocytic, nonendocrine neoplasm of the anterior hypophysis that manifests in adults and follows a benign clinical course. Pituitary spindle cell oncocytomas are firm, fibrous, and adherent to surrounding structures and are highly vascular." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35524 ; owl:annotatedTarget "sympathomimetic" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011766 ; owl:annotatedTarget "A structural abnormality of the parathyroid gland." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011767 ; owl:annotatedTarget "A functional abnormality of the parathyroid gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35524 ; owl:annotatedTarget "sympathomimetics" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011767 ; owl:annotatedTarget "Parathyroid issue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011767 ; owl:annotatedTarget "Parathyroid dysfunction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011768 ; owl:annotatedTarget "Abnormal embryonic development of the parathyroid gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antidiabetic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011769 ; owl:annotatedTarget "An abnormal anatomical location of the parathyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011770 ; owl:annotatedTarget "A type of hyperparathyroidism that occurs following kidney transplantation, which is a treatment for secondary hyperparathyroidism. Although kidney transplantation leads to a normalization of serum calcium and parathyroid hormone in most patients. The state of persistent hypercalcemia and hyperparathyroidism is referred to as tertiary hyperparathyroidism." . [] oboInOwl:hasDbXref , "PMID:19328421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011771 ; owl:annotatedTarget "A type of hypoparathyroidism with circulating antiparathyroid or anti-calcium sensing receptor antibodies indicative of autoimmunity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011772 ; owl:annotatedTarget "A structural abnormality of the thyroid gland." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011772 ; owl:annotatedTarget "Abnormal shape of thyroid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011773 ; owl:annotatedTarget "Enlargement of the thyroid gland related to a singular nodule in the thyroid gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemic agent" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011773 ; owl:annotatedTarget "Uninodular goitre" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011780 ; owl:annotatedTarget "Absence of a lobe of the thyroid gland related to a failure of its embryologic development." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011781 ; owl:annotatedTarget "An abnormal growth of parafollicular (C-cells) cells." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011785 ; owl:annotatedTarget "Thyrotoxicosis with toxic multinodular goitre" . [] oboInOwl:hasDbXref , "PMID:18415684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011787 ; owl:annotatedTarget "A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:2403792" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011788 ; owl:annotatedTarget "An elevated concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011788 ; owl:annotatedTarget "Increased serum fT3" . [] oboInOwl:hasDbXref "PMID:28648507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011789 ; owl:annotatedTarget "Reduced sensitivity of thyroid follicle cells to stimulation by biologically active thyroid-stimulating hormone (TSH)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011790 ; owl:annotatedTarget "Gain-of-function thyroid-stimulating hormone receptor (TSHR) defect." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemic drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011791 ; owl:annotatedTarget "Loss-of-function thyroid-stimulating hormone receptor (TSHR) defect." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011792 ; owl:annotatedTarget "Neoplasm categorized according to type of histological abnormality." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011793 ; owl:annotatedTarget "Neoplasm categorized according to the anatomical site of origin of the neoplasm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011794 ; owl:annotatedTarget "The presence of an embryonal neoplasm of the kidney that primarily affects children." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011795 ; owl:annotatedTarget "Presence of persistent islands of renal blastema in the postnatal kidney, anywhere within a renal lobe (a portion of a kidney consisting of a renal pyramid and the renal cortex above it)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011796 ; owl:annotatedTarget "Abnormally persistent foci of embryonal immature blastema located in the superficial cortical region (perilobar)." . [] oboInOwl:hasDbXref , "PMID:12429790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011797 ; owl:annotatedTarget "A type of papillary renal cell carcinoma that is characterized by small cuboidal cells covering thin papillae with a single line of uniform nuclei and small nucleoli." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011798 ; owl:annotatedTarget "A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011799 ; owl:annotatedTarget "Abnormality of facial soft tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011799 ; owl:annotatedTarget "Anomaly of facial soft tissue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemic drugs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011799 ; owl:annotatedTarget "Deformity of facial soft tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011799 ; owl:annotatedTarget "Malformation of facial soft tissue" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "antihyperglycemics" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Small midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Decreased size of midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Midface deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Midface hypoplasia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Midface retrusion" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Retrusive midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Underdevelopment of midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Decreased projection of midface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011800 ; owl:annotatedTarget "Hypotrophic midface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011801 ; owl:annotatedTarget "Increased size of the parotid gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "hypoglycemic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011801 ; owl:annotatedTarget "Increased size of parotid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011801 ; owl:annotatedTarget "Hypertrophy of parotid gland" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "hypoglycemic drug" . [] oboInOwl:hasDbXref , "PMID:17667541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011802 ; owl:annotatedTarget "A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011802 ; owl:annotatedTarget "Lingual hamartoma" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35526 ; owl:annotatedTarget "hypoglycemic drugs" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Bifid nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Indentation or clefting of the nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Cleft nasal bridge" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Cleft nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011803 ; owl:annotatedTarget "Indented bridge of nose" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35552 ; owl:annotatedTarget "heterocyclic parent hydrides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011804 ; owl:annotatedTarget "A functional abnormality of a skeletal muscle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011804 ; owl:annotatedTarget "Issue with muscle function" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35552 ; owl:annotatedTarget "heterocyclic fundamental parent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011805 ; owl:annotatedTarget "A structural abnormality of a skeletal muscle." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011805 ; owl:annotatedTarget "Abnormally shaped muscle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011805 ; owl:annotatedTarget "Issue with muscle structure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011807 ; owl:annotatedTarget "Atrophy (wasting) affecting primary type 1 muscle fibers. This feature in general can only be observed on muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011807 ; owl:annotatedTarget "Type 1 muscle fibre atrophy" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35552 ; owl:annotatedTarget "heterocyclic organic fundamental parents" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:24501112" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35552 ; owl:annotatedTarget "organic heterocyclic fundamental parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011808 ; owl:annotatedTarget "Decreased intensity of the patellar reflex (also known as the knee jerk reflex)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011808 ; owl:annotatedTarget "Decreased knee jerk reflex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011808 ; owl:annotatedTarget "Decreased patellar reflexes" . [] oboInOwl:hasDbXref , "PMID:7678441" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011809 ; owl:annotatedTarget "A type of myotonia that worsens with repeated muscle contractions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011810 ; owl:annotatedTarget "A reduced ability to distinguish tactile sensations at points that are very close to one another. This can be tested by using special calipers whose points can be set from 2mm to several centimeters apart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011811 ; owl:annotatedTarget "A reduced ability to identify precisely the site of a touch. This test is usually carried out by asking a patient, whose eyes are closed or covered, to touch the same site with a fingertip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011811 ; owl:annotatedTarget "Impaired topognosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011811 ; owl:annotatedTarget "Impaired touch localisation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011812 ; owl:annotatedTarget "Impaired ability to recognize letters or numbers drawn by an examiner's fingertip on the patient's skin (the patients eyes are closed or covered throughout this examination)." . [] oboInOwl:hasDbXref , "PMID:9531959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011813 ; owl:annotatedTarget "Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. This term pertains if there is an increase in the accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35554 ; owl:annotatedTarget "cardiovascular agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35554 ; owl:annotatedTarget "cardiovascular drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011814 ; owl:annotatedTarget "The concentration of hypoxanthine in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref , "PMID:24931720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011815 ; owl:annotatedTarget "A congenital defect in the skull, whereby there is a protrusion of part of the cranial contents through a congenital defect in the cranium, usually covered with skin or mucous membrane. The term encephalocele refers to a subclass of these lesions in which brain tissue protrudes through the defect." . [] oboInOwl:hasDbXref , "PMID:2773494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011816 ; owl:annotatedTarget "An encephalocele located between bregma and lambda." . [] oboInOwl:hasDbXref , "PMID:4966739" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011817 ; owl:annotatedTarget "Basal encephalocele is an encephalocele that occurs along the cribriform plate or through the sphenoid bone. The mass may appear in the nasal cavity, nasopharynx, epipharynx, sphenoid sinus, posterior orbit, or pterygopalatine fossa. The important distinction from other types is that no external tumor is visible except in those rare instances of herniations so large that they protrude through the mouth or nares." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35568 ; owl:annotatedTarget "mancude-ring systems" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011819 ; owl:annotatedTarget "A cleft of the muscular (soft) portion of the palate that is covered by mucous membrane. Soft-palate submucous clefts are characterized by a midline deficiency or lack of muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011819 ; owl:annotatedTarget "Partial thickness cleft soft palate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011819 ; owl:annotatedTarget "Submucous cleft velum" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jhurst" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011820 ; owl:annotatedTarget "Absence of the normal opening of the choana (the posterior nasal aperture) as a result of an obstructing choanal membrane that may be thin and strandlike or thick and pluglike." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35568 ; owl:annotatedTarget "mancude rings" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "An abnormality of one or more of the set of bones that make up the facial skeleton." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Abnormality of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Anomaly of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Abnormality of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Anomaly of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Deformity of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Deformity of the facial bones" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35568 ; owl:annotatedTarget "mancunide-ring systems" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Malformation of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011821 ; owl:annotatedTarget "Malformation of facial skeleton" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011822 ; owl:annotatedTarget "Increased width of the midpoint of the mandible (mental protuberance) and overlying soft tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35569 ; owl:annotatedTarget "alpha-adrenergic agonists" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011822 ; owl:annotatedTarget "Broad chin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011822 ; owl:annotatedTarget "Increased width of chin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011822 ; owl:annotatedTarget "Increased width of menton region" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011822 ; owl:annotatedTarget "Wide chin" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011823 ; owl:annotatedTarget "Horizontal crease or fold situated below the vermilion border of the lower lip and above the fatty pad of the chin, with the face at rest." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011823 ; owl:annotatedTarget "Chin with horizontal crease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011823 ; owl:annotatedTarget "Chin with horizontal groove" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011823 ; owl:annotatedTarget "Horizontal chin skin cleft" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011823 ; owl:annotatedTarget "Horizontal menton crease" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011824 ; owl:annotatedTarget "H-shaped crease in the fat pad of the chin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35569 ; owl:annotatedTarget "alpha-adrenergic receptor agonist" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011824 ; owl:annotatedTarget "Chin with H-shaped crease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011824 ; owl:annotatedTarget "Chin, H-Shaped Crease" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011824 ; owl:annotatedTarget "Chin, H-shaped groove" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011824 ; owl:annotatedTarget "H-shaped dimple of the chin" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011825 ; owl:annotatedTarget "Prominence of a triangular soft tissue area of the philtrum with the apex to the columella." . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011826 ; owl:annotatedTarget "Narrow ridge in the midline of the philtral groove." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011826 ; owl:annotatedTarget "Philtrum with central raphe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011826 ; owl:annotatedTarget "Philtrum with midline ridge" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011827 ; owl:annotatedTarget "Absence of the usual parallel position of philtral ridges." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011827 ; owl:annotatedTarget "Asymmetric philtral columns" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35569 ; owl:annotatedTarget "alpha-adrenoceptor agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011827 ; owl:annotatedTarget "Asymmetric philtral ridges" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011827 ; owl:annotatedTarget "Malaligned philtral columns" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011828 ; owl:annotatedTarget "Pit in the midline of the philtral groove." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011828 ; owl:annotatedTarget "Central sinus of philtrum" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations below the mean. Alternatively, an apparently decreased distance between the ridges of the philtrum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Decreased breadth of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Decreased horizontal dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Decreased transverse dimension of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Decreased width of philtrum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011829 ; owl:annotatedTarget "Thin philtrum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35570 ; owl:annotatedTarget "mancude organic heterobicyclic parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011830 ; owl:annotatedTarget "Abnormality of the oral mucosa." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011830 ; owl:annotatedTarget "Abnormality of lining of mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011830 ; owl:annotatedTarget "Abnormality of mucosa of mouth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:32898608" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35570 ; owl:annotatedTarget "mancude-ring organic heterobicyclic parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011830 ; owl:annotatedTarget "Abnormality of oral mucous membrane" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Nasal tip positioned to one side of the midline." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Asymmetry of nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Asymmetry of tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Crooked nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Crooked tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Deviated nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Deviated tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0011831 ; owl:annotatedTarget "Distortion of the nasal tip" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Decrease in width of the nasal tip." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35571 ; owl:annotatedTarget "mancude organic heterocyclic parents" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Narrow nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Narrow tip of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Nasal tip, narrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Nasal tip, pinched" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Pinched nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Pinched tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Thin nasal tip" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011832 ; owl:annotatedTarget "Thin tip of nose" . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Positioning of the nasal tip inferior to the nasal base." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Drooping nasal tip" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35571 ; owl:annotatedTarget "mancude-ring organic heterocyclic parents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Hooked tip of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Low hanging nasal tip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Nasal tip, overhanging" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011833 ; owl:annotatedTarget "Overhanging nasal tip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011834 ; owl:annotatedTarget "A noninflammatory, progressive occlusion of the intracranial carotid arteries owing to the formation of netlike collateral arteries arising from the circle of Willis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35573 ; owl:annotatedTarget "organic mancude parents" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_jcampbell" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011835 ; owl:annotatedTarget "Congenital absence of the scaphoid.." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011835 ; owl:annotatedTarget "Missing scaphoid bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011835 ; owl:annotatedTarget "Absent scaphoid bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35573 ; owl:annotatedTarget "organic mancude-ring parents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011836 ; owl:annotatedTarget "Delayed maturation and calcification of the talus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011837 ; owl:annotatedTarget "Detectable but decreased IgA levels that are more than 2 standard deviations below normal age-adjusted means." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011838 ; owl:annotatedTarget "Localized thickening and tightness of the skin of the fingers or toes." . [] a owl:Axiom ; rdfs:label "Sclerodactyly" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0011838 ; owl:annotatedTarget "ICD-10:L94.3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011839 ; owl:annotatedTarget "A deviation from the normal count of T cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011839 ; owl:annotatedTarget "Abnormal number of T cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011839 ; owl:annotatedTarget "Abnormality of T cell number" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35584 ; owl:annotatedTarget "PMID:12865945" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011840 ; owl:annotatedTarget "A functional anomaly of T cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011841 ; owl:annotatedTarget "A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35584 ; owl:annotatedTarget "PMID:24088627" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011842 ; owl:annotatedTarget "An abnormality of the form, structure, or size of the skeletal system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011842 ; owl:annotatedTarget "Abnormally shaped skeletal" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35584 ; owl:annotatedTarget "purine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011843 ; owl:annotatedTarget "An abnormality of the function of the skeletal system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011844 ; owl:annotatedTarget "An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33271839" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011845 ; owl:annotatedTarget "Short (hypoplastic) second metatarsal bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011845 ; owl:annotatedTarget "Short 2nd long bone of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011846 ; owl:annotatedTarget "A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011847 ; owl:annotatedTarget "A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011847 ; owl:annotatedTarget "Giant cell tumour of bone" . [] oboInOwl:hasDbXref , "PMID:18157903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011849 ; owl:annotatedTarget "Any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." . [] a owl:Axiom ; rdfs:label "Abnormal bone ossification" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0011849 ; owl:annotatedTarget "MP:0008271" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011849 ; owl:annotatedTarget "Abnormal bone maturation" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35586 ; owl:annotatedTarget "Gmelin:2379911" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011850 ; owl:annotatedTarget "Inflammation of the parotid gland." . [] oboInOwl:hasDbXref , "PMID:10882282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011851 ; owl:annotatedTarget "Accumulation of blood within the pericardial sac." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011852 ; owl:annotatedTarget "Accumulation of chyle (the whitish fluid taken up by the lacteals in the intestine, consisting of an emulsion of lymph and triglyceride fat thatpasses into the veins by the thoracic duct) in the pericardium. Chylopericardium is generally caused by obstruction of or trauma to the thoracic duct." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011853 ; owl:annotatedTarget "Accumulation of serous fluid (pale yellow and transparent fluid) in the pericardial sac." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011854 ; owl:annotatedTarget "Accumulation of blood in the peritoneal cavity owing to internal hemorrhage." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011854 ; owl:annotatedTarget "Hematoperitoneum" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35586 ; owl:annotatedTarget "1H-purine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011855 ; owl:annotatedTarget "Abnormal accumulation of fluid leading to swelling of the pharynx." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011855 ; owl:annotatedTarget "Pharyngeal oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011855 ; owl:annotatedTarget "Throat swelling" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011856 ; owl:annotatedTarget "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011857 ; owl:annotatedTarget "A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011858 ; owl:annotatedTarget "Decreased activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011859 ; owl:annotatedTarget "A type of keratitis characterized by inflammation in pinpoint areas of the corneal epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011860 ; owl:annotatedTarget "The presence of spots or rounded patches of abnormally increased density of metaphyseal bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011861 ; owl:annotatedTarget "Both lungs have three lobes. Normally, the left lung has two lobes, whereas the right lung has three lobes." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011861 ; owl:annotatedTarget "Bilateral trilobed lungs" . [] oboInOwl:hasDbXref , "MP:0011642" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011862 ; owl:annotatedTarget "Any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011863 ; owl:annotatedTarget "Any anomaly in the formation of the bony substance of the sternum." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011863 ; owl:annotatedTarget "Abnormal maturation of breastbone" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011863 ; owl:annotatedTarget "Sternal ossification centre abnormalities" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35588 ; owl:annotatedTarget "PMID:6149478" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011864 ; owl:annotatedTarget "An abnormally increased diphosphate(4-) concentration in the blood. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35588 ; owl:annotatedTarget "PMID:7178185" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011867 ; owl:annotatedTarget "An anomaly of the ilium ala. This is the large expanded portion of the ilum which bounds the greater pelvis laterally." . [] oboInOwl:hasDbXref , "PMID:17872935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011868 ; owl:annotatedTarget "Pain in the lower back and hip radiating in the distribution of the sciatic nerve." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35588 ; owl:annotatedTarget "PMID:7296170" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011869 ; owl:annotatedTarget "Any anomaly in the function of thrombocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011870 ; owl:annotatedTarget "Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011871 ; owl:annotatedTarget "Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011872 ; owl:annotatedTarget "Abnormal response to thrombin or thrombin mimetics as manifested by reduced or lacking aggregation of platelets upon addition of thrombin (or thrombin mimetics)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33559528" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35588 ; owl:annotatedTarget "Reaxys:1210196" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011873 ; owl:annotatedTarget "Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." . [] oboInOwl:hasDbXref , "PMID:16928996" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011874 ; owl:annotatedTarget "Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35588 ; owl:annotatedTarget "3H-purine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011875 ; owl:annotatedTarget "An anomaly in platelet form, ultrastructure, or intracellular organelles." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011875 ; owl:annotatedTarget "Abnormal shape of platelets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011876 ; owl:annotatedTarget "Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011877 ; owl:annotatedTarget "Average platelet volume above the upper limit of the normal reference interval." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011877 ; owl:annotatedTarget "Large platelets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011878 ; owl:annotatedTarget "Presence of reduced amount of a membrane protein on the cell membrane of platelets. This feature is typically measured by flow cytometry." . [] oboInOwl:hasDbXref , "PMID:10605725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011879 ; owl:annotatedTarget "Decreased cell membrane concentration of the glycoprotein complex Ib-IX-V." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011880 ; owl:annotatedTarget "An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011881 ; owl:annotatedTarget "Decreased cell membrane concentration of glycoprotein VI." . [] oboInOwl:hasDbXref , "PMID:14755328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011882 ; owl:annotatedTarget "Decreased cell membrane concentration of P2Y12 receptor." . [] oboInOwl:hasDbXref , "PMID:18041654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011883 ; owl:annotatedTarget "An anomaly of alpha or dense granules or platelet lysosomes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011884 ; owl:annotatedTarget "Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35589 ; owl:annotatedTarget "Beilstein:606899" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011885 ; owl:annotatedTarget "Bleeding from vessels of the various tissues of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011885 ; owl:annotatedTarget "Bleeding from the eye" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011885 ; owl:annotatedTarget "Haemorrhage of the eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011886 ; owl:annotatedTarget "Bleeding in the anterior chamber of the eye." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35589 ; owl:annotatedTarget "CAS:120-73-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011887 ; owl:annotatedTarget "Hemorrhage from the vessels of the choroid." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011887 ; owl:annotatedTarget "Choroid haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011887 ; owl:annotatedTarget "Choroidal haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011888 ; owl:annotatedTarget "Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011888 ; owl:annotatedTarget "Bleeding requiring red cell transfusion" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35589 ; owl:annotatedTarget "Gmelin:3120" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011889 ; owl:annotatedTarget "Significant bleeding or hemorrhage without significant precipitating factor." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011889 ; owl:annotatedTarget "Bleeding with minor or no trauma" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011889 ; owl:annotatedTarget "Easy bleeding" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011890 ; owl:annotatedTarget "Prolonged or protracted bleeding following an invasive procedure or intervention." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011890 ; owl:annotatedTarget "Prolonged bleeding following procedure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011891 ; owl:annotatedTarget "Significant maternal haemorrhage/blood loss following deilvery of a child." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011891 ; owl:annotatedTarget "Bleeding post-delivery" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35589 ; owl:annotatedTarget "9H-purine" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35589 ; owl:annotatedTarget "9H-purine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011893 ; owl:annotatedTarget "Number of leukocytes per volume of blood beyond normal limits." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011893 ; owl:annotatedTarget "Abnormal white blood cell count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011894 ; owl:annotatedTarget "Abnormal response to thromboxane as manifested by reduced or lacking aggregation of platelets upon addition of thromboxane A2 receptor agonists." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011895 ; owl:annotatedTarget "A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011896 ; owl:annotatedTarget "Bleeding beneath the mucous membrane that lines the inner surface of the eyelid." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011896 ; owl:annotatedTarget "Subconjunctival haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011897 ; owl:annotatedTarget "Increased number of neutrophils circulating in blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011897 ; owl:annotatedTarget "Increased blood neutrophil counts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011898 ; owl:annotatedTarget "An abnormality of the level of activity of circulating fibrinogen." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33685091" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35604 ; owl:annotatedTarget "carbon oxoanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011899 ; owl:annotatedTarget "Increased concentration of fibrinogen in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011900 ; owl:annotatedTarget "Decreased concentration of fibrinogen in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011901 ; owl:annotatedTarget "Qualitatively abnormal fibrinogen." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35604 ; owl:annotatedTarget "carbon oxoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011902 ; owl:annotatedTarget "Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011902 ; owl:annotatedTarget "Abnormal Hb" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011902 ; owl:annotatedTarget "Abnormal haemoglobin" . [] oboInOwl:hasDbXref , "PMID:21345100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011903 ; owl:annotatedTarget "Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011903 ; owl:annotatedTarget "Haemoglobin H" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011903 ; owl:annotatedTarget "HbH haemoglobin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011904 ; owl:annotatedTarget "Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011904 ; owl:annotatedTarget "Increased haemoglobin F" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011904 ; owl:annotatedTarget "Persistence of HbF" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011904 ; owl:annotatedTarget "Persistence of haemoglobin F" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35604 ; owl:annotatedTarget "oxocarbon anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011905 ; owl:annotatedTarget "Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011905 ; owl:annotatedTarget "Reduced HbA" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011905 ; owl:annotatedTarget "Reduced haemoglobin A" . [] oboInOwl:hasDbXref , "PMID:1060068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011906 ; owl:annotatedTarget "A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011907 ; owl:annotatedTarget "A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011908 ; owl:annotatedTarget "Missing radius bone on one side only associated with congenital failure of development." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011909 ; owl:annotatedTarget "Abnormally flat shape of the heads of the metacarpal bones." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011909 ; owl:annotatedTarget "Flattened head of long bone of hand" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011910 ; owl:annotatedTarget "Abnormal reduction in length affecting all phalanges." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011910 ; owl:annotatedTarget "Shortening of all finger bones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35604 ; owl:annotatedTarget "oxocarbon anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011911 ; owl:annotatedTarget "An anomaly of a metacarpophalangeal joint." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011911 ; owl:annotatedTarget "Abnormality of the knuckle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35605 ; owl:annotatedTarget "carbon oxoacids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011912 ; owl:annotatedTarget "An anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011913 ; owl:annotatedTarget "Excessive, increased hair growth located in the lumbar region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011914 ; owl:annotatedTarget "Excessive, increased hair growth located in the thoracic region." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35605 ; owl:annotatedTarget "oxoacids of carbon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011915 ; owl:annotatedTarget "Abnormal calcification in the cardiovascular system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011916 ; owl:annotatedTarget "Atrophy of the extensor digitorum longus muscles, which mediate extension of the toes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35610 ; owl:annotatedTarget "anticancer agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011917 ; owl:annotatedTarget "Underdevelopment (hypoplasia) of the fifth toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011917 ; owl:annotatedTarget "Short little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011917 ; owl:annotatedTarget "Short pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011917 ; owl:annotatedTarget "Short pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35610 ; owl:annotatedTarget "anticancer agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011918 ; owl:annotatedTarget "Bending or curvature of a fourth toe in the tibial direction (i.e., towards the big toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0011918 ; owl:annotatedTarget "Curvature of 4th toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011919 ; owl:annotatedTarget "Accumulation of pus in the pleural cavity." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_tkuijpers", "PMID:16623208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011920 ; owl:annotatedTarget "A type of pleural effusion with a transudate (extravascular fluid with low protein content and a low specific gravity). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35610 ; owl:annotatedTarget "antineoplastic" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_tkuijpers", "PMID:16623208" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011921 ; owl:annotatedTarget "A type of pleural effusion with a exudate (extravascular fluid that has exuded out of a tissue or its capillaries due to injury or inflammation). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35610 ; owl:annotatedTarget "antineoplastic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011922 ; owl:annotatedTarget "An increased or decreased activity of the mitochondrial respiratory chain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011923 ; owl:annotatedTarget "A reduction in the activity of the mitochondrial respiratory chain complex I, which is part of the electron transport chain in mitochondria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011924 ; owl:annotatedTarget "A reduction in the activity of the mitochondrial respiratory chain complex III, which is part of the electron transport chain in mitochondria." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33715333" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35610 ; owl:annotatedTarget "cytostatic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011925 ; owl:annotatedTarget "A reduction in the activity of the mitochondrial proton-transporting ATP synthase complex, which makes ATP via oxidative phosphorylation, and is sometimes described as Complex V of the electron transport chain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35617 ; owl:annotatedTarget "flavoring agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011926 ; owl:annotatedTarget "Proximal mislocalization of the big toe from its normal position." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011926 ; owl:annotatedTarget "Proximally placed halluces" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011927 ; owl:annotatedTarget "One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35617 ; owl:annotatedTarget "flavoring agents" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011927 ; owl:annotatedTarget "Short digit" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011927 ; owl:annotatedTarget "Very short digits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011928 ; owl:annotatedTarget "Developmental hypoplasia (shortening) of proximal phalanx of toe." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35617 ; owl:annotatedTarget "flavour enhancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011928 ; owl:annotatedTarget "Short innermost toe bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011929 ; owl:annotatedTarget "Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011930 ; owl:annotatedTarget "Hyperelastic chest skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011930 ; owl:annotatedTarget "Stretchable chest skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35617 ; owl:annotatedTarget "flavour enhancers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011931 ; owl:annotatedTarget "An anomaly of the cerebellar peduncles. The superior, middle, and inferior cerebellar peduncles emerge from the cerebellum. The superior cerebellar penduncles connect the cerebellum to the midbrain, the middle cerebellar peduncles connect the cerebellum to the pons, and the inferior cerebellar peduncle connects the medulla spinalis and medulla oblongata with the cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011932 ; owl:annotatedTarget "An anomaly of the superior cerebellar peduncle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35617 ; owl:annotatedTarget "flavouring agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011933 ; owl:annotatedTarget "Increased length of the superior cerebellar peduncle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011933 ; owl:annotatedTarget "Long cerebellar peduncle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011933 ; owl:annotatedTarget "Elongated superior cerebellar peduncles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35620 ; owl:annotatedTarget "vasodilator" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011934 ; owl:annotatedTarget "Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery or superior mesenteric artery ." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35620 ; owl:annotatedTarget "vasodilator agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011935 ; owl:annotatedTarget "Decreased concentration of urate in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011936 ; owl:annotatedTarget "A decreased concentration of total carnitine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011936 ; owl:annotatedTarget "Decreased plasma total carnitine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011937 ; owl:annotatedTarget "Underdeveloped nails of the fifth toes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011937 ; owl:annotatedTarget "Small fifth toenail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011937 ; owl:annotatedTarget "Underdeveloped fifth toenail" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011939 ; owl:annotatedTarget "A soft tissue continuity in the A/P axis between fingers 3 and 4." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011940 ; owl:annotatedTarget "An abnormality of the shape of the thoracic vertebra T12 such that it is wedge-shaped (narrow towards the front)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011941 ; owl:annotatedTarget "An abnormality of the shape of the lumbar vertebra L2 such that it is wedge-shaped (narrow towards the front)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011942 ; owl:annotatedTarget "The concentration of SO3(2-), i.e., sulfite, in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33782420" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011943 ; owl:annotatedTarget "Increased concentration of thiosulfate(2-) in the urine." . [] oboInOwl:hasDbXref , "PMID:9366584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011944 ; owl:annotatedTarget "A type of vasculitis (inflammation of blood vessel walls) that affects blood vessels that are smaller than arteries, i.e., arterioles, venules, and capilllaries." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:DDD_tkuijpers", "PMID:20858818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011945 ; owl:annotatedTarget "Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011945 ; owl:annotatedTarget "BOOP" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011945 ; owl:annotatedTarget "Bronchiolitis obliterans organising pneumonia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011945 ; owl:annotatedTarget "Cryptogenic organising pneumonia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011946 ; owl:annotatedTarget "Inflammation and fibrosis of the bronchioles leading to partial or complete obstruction of these airways." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011947 ; owl:annotatedTarget "An infection of the upper or lower respiratory tract." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011947 ; owl:annotatedTarget "Respiratory infection" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011947 ; owl:annotatedTarget "Respiratory tract infection" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "Beilstein:635889" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0011947 ; owl:annotatedTarget "Respiratory infections" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011948 ; owl:annotatedTarget "A history of repeated acute infections of the upper or lower respiratory tract." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011948 ; owl:annotatedTarget "Acute respiratory tract infection" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011949 ; owl:annotatedTarget "Acute inflammation of the lung due to an infection." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011950 ; owl:annotatedTarget "Inflammation of the bronchioles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011951 ; owl:annotatedTarget "Pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011952 ; owl:annotatedTarget "An acute episode of pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:DDD_tkuijpers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011953 ; owl:annotatedTarget "Lung parenchymal involvement with lymphoma." . [] oboInOwl:hasDbXref "PMID:21472097" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011954 ; owl:annotatedTarget "Diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011955 ; owl:annotatedTarget "The presence of multiple granulomas in the liver as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "CAS:2835-81-6" . [] oboInOwl:hasDbXref , "PMID:21481240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011956 ; owl:annotatedTarget "A lymphoproliferative abnormality of the intestine characterized by numerous visible mucosal nodules measuring up to, and rarely exceeding, 0.5 cm in diameter Histologically, hyperplastic lymphoid follicles with large germinal centres are seen in the lamina propria and superficial submucosa. There is enlargement of the mucosal B cell follicles caused by hyperplasia of the follicle centres; surrounded by a normal appearing mantle zone. Disease may involve the stomach, the entire small intestine, and the large intestine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011957 ; owl:annotatedTarget "An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011957 ; owl:annotatedTarget "Abnormal pec muscles" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "CAS:2835-81-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011958 ; owl:annotatedTarget "A small hole through the whole thickness of the retina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011958 ; owl:annotatedTarget "Retinal tear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011958 ; owl:annotatedTarget "Torn retina" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "Gmelin:217679" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011959 ; owl:annotatedTarget "Hypoplasia (underdevelopment) of the pectoralis minor on only one side of the chest." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011959 ; owl:annotatedTarget "Small pec muscle on one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011959 ; owl:annotatedTarget "Underdeveloped pec muscle on one side" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:11958629" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011960 ; owl:annotatedTarget "Focal proliferation of glial cells in the substantia nigra." . [] oboInOwl:hasDbXref , "PMID:20514278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011961 ; owl:annotatedTarget "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy." . [] oboInOwl:hasDbXref , "PMID:20514278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011962 ; owl:annotatedTarget "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy." . [] oboInOwl:hasDbXref , "PMID:20514278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011963 ; owl:annotatedTarget "Absence of any measurable level of sperm in his semen, due to a hypothalamic or pituitary abnormality diagnosed with hypo-gonadotropic-hypogonadism. The diagnosis is made on the basis of low LH and FSH levels and low or normal testosterone levels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011964 ; owl:annotatedTarget "History of repeated intermittent involuntary muscle contractions that were painful." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:15246869" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011965 ; owl:annotatedTarget "Any deviation from the normal concentration of citrulline in the blood circulation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:20551690" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011966 ; owl:annotatedTarget "An increased concentration of citrulline in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:22061039" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011967 ; owl:annotatedTarget "A reduced concentration of copper in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011967 ; owl:annotatedTarget "Copper deficiency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011968 ; owl:annotatedTarget "Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011968 ; owl:annotatedTarget "Feeding difficulties" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011968 ; owl:annotatedTarget "Feeding problems" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011968 ; owl:annotatedTarget "Poor feeding" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33811074" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011969 ; owl:annotatedTarget "An elevated concentration of luteinizing hormone in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011969 ; owl:annotatedTarget "Elevated LH level" . [] oboInOwl:hasDbXref , "PMID:21519520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011970 ; owl:annotatedTarget "Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "Reaxys:635889" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011971 ; owl:annotatedTarget "An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011971 ; owl:annotatedTarget "Skin writing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011972 ; owl:annotatedTarget "Abnormally low glucose concentration in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011972 ; owl:annotatedTarget "Low glucose levels in cerebral spinal fluid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011973 ; owl:annotatedTarget "Repeated episodes of sudden-onset and transient lethargy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011974 ; owl:annotatedTarget "Replacement of bone marrow by fibrous tissue." . [] oboInOwl:hasDbXref , "PMID:2669624" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011975 ; owl:annotatedTarget "Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "2-aminobutanoic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011976 ; owl:annotatedTarget "The concentration of a catecholamine in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011976 ; owl:annotatedTarget "Elevated urinary catecholamines" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "alpha-aminobutyric acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "2-amino-n-butyric acid" . [] oboInOwl:hasDbXref , "PMID:27830764" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011977 ; owl:annotatedTarget "An increased concentration of homovanillic acid in the urine." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "2-aminobutyric acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011978 ; owl:annotatedTarget "An increased concentration of vanillylmandelic acid in the urine." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "AABA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011979 ; owl:annotatedTarget "The concentration of dopamine in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011979 ; owl:annotatedTarget "Elevated urinary dopamine" . [] oboInOwl:hasDbXref , "PMID:12950109", "PMID:16844493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011980 ; owl:annotatedTarget "Gallstones composed primarily of cholesterol, usually about 2-3 cm in length with an oval form and a yellow or green/brown color." . [] oboInOwl:hasDbXref , "PMID:12950109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011981 ; owl:annotatedTarget "Gallstones composed primarily of bilirubin and calcium salts (calcium bilirubinate) with a low cholesterol concentration." . [] oboInOwl:hasDbXref , "PMID:12950109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011982 ; owl:annotatedTarget "A type of pigment gallstone that is hard and black, containing calcium carbonate and calcium phosphates." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "Abu" . [] oboInOwl:hasDbXref , "PMID:12950109" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011983 ; owl:annotatedTarget "A type of pigment gallstone that is brown, containing calcium fatty acids. These stones are softer than black pigment gallstones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011984 ; owl:annotatedTarget "Failure of formation of the lumen of the gallbladder, often associated with gallbladder hypoplasia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011985 ; owl:annotatedTarget "Clay colored stools lacking bile pigment." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "alpha-amino-n-butyric acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011985 ; owl:annotatedTarget "Clay colored stools" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011985 ; owl:annotatedTarget "Clay coloured stools" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011986 ; owl:annotatedTarget "Formation of abnormal, extraskeletal bony tissue, i.e., the presence of bone in soft tissue where bone normally does not exist." . [] a owl:Axiom ; rdfs:label "Ectopic ossification" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0011986 ; owl:annotatedTarget "MEDDRA:10065453" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011987 ; owl:annotatedTarget "Formation of abnormal bony tissue within muscle tissue." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011987 ; owl:annotatedTarget "Calcification of muscle tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011988 ; owl:annotatedTarget "Formation of abnormal bony tissue within tendon tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011989 ; owl:annotatedTarget "Formation of abnormal bony tissue within ligament tissue." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "butyrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011990 ; owl:annotatedTarget "A functional abnormality of neutrophils." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:33958485" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35621 ; owl:annotatedTarget "homoalanine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011991 ; owl:annotatedTarget "A deviation from the normal range of neutrophil cell counts in the circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "Antiepileptika" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011992 ; owl:annotatedTarget "An abnormal form or size of neutrophils." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "Antiepileptikum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011993 ; owl:annotatedTarget "A reduction in the ability of neutrophils to kill bacteria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011994 ; owl:annotatedTarget "An abnormality of the interatrial septum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "Antikonvulsiva" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011994 ; owl:annotatedTarget "Abnormal interatrial septum morphology" . [] oboInOwl:hasDbXref , "PMID:7758185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011995 ; owl:annotatedTarget "A bulging of the interatrial septum towards one side. In adults, atrial septal aneurysm can be defined as a protrusion of the aneurysm of >10 mm beyond the plane of the atrial septum as measured by transesophageal echocardiography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011996 ; owl:annotatedTarget "Increased activity of coagulation factor V, Factor V, which is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011997 ; owl:annotatedTarget "Abnormally increased level of blood lactate following a meal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011998 ; owl:annotatedTarget "An increased concentration of glucose in the blood following a meal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0011999 ; owl:annotatedTarget "A persecutory delusion of supposed hostility of others." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0011999 ; owl:annotatedTarget "Paranoia" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012000 ; owl:annotatedTarget "EEG with generalized sharp transient waves of a duration less than 80 msec." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012000 ; owl:annotatedTarget "EEG with generalised spikes" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012001 ; owl:annotatedTarget "EEG with repetitive generalized sharp transient waves of a duration less than 80 msec." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "Antikonvulsivum" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012001 ; owl:annotatedTarget "EEG with generalised polyspikes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012002 ; owl:annotatedTarget "Affective, mnemonic or composite perceptual auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012002 ; owl:annotatedTarget "Experiential auras" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012003 ; owl:annotatedTarget "Affective auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012003 ; owl:annotatedTarget "Affective auras" . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012004 ; owl:annotatedTarget "A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012004 ; owl:annotatedTarget "Mnemonic auras" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012005 ; owl:annotatedTarget "A subjective feeling that an experience which is occurring for the first time has been experienced before." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012005 ; owl:annotatedTarget "Deja vu" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012006 ; owl:annotatedTarget "A subjective feeling that an experience which has occurred before is being experienced for the first time." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anti-convulsant" . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012007 ; owl:annotatedTarget "A focal cognitive seizure characterized by hallucination as the initial semiological manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012007 ; owl:annotatedTarget "Hallucinatory auras" . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012008 ; owl:annotatedTarget "A focal cognitive seizure characterized by an alteration of actual perception involving visual, auditory, somatosensory, olfactory, and/or gustatory phenomena as the initial semiological manifestation." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012008 ; owl:annotatedTarget "Illusory auras" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012009 ; owl:annotatedTarget "EEG with focal sharp transient waves in the central region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012010 ; owl:annotatedTarget "EEG with focal sharp transient waves in the frontal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012011 ; owl:annotatedTarget "EEG with focal sharp transient waves in the occipital region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012012 ; owl:annotatedTarget "EEG with focal sharp transient waves in the parietal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012013 ; owl:annotatedTarget "EEG with focal sharp transient waves in the temporal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012014 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec in the central region." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anti-convulsants" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012015 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec in the frontal region." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012016 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec in the occipital region." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012017 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec in the parietal region." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jalbers" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012018 ; owl:annotatedTarget "EEG with focal sharp transient waves of a duration less than 80 msec in the temporal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012019 ; owl:annotatedTarget "Complete dislocation of the lens of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012019 ; owl:annotatedTarget "Dislocated lens" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012019 ; owl:annotatedTarget "Dislocated lenses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012020 ; owl:annotatedTarget "Aorta descends on right instead of on the left." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anti-convulsive agent" . [] oboInOwl:hasDbXref , "PMID:16449256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012021 ; owl:annotatedTarget "Persistence of blood flow through the ductus venosus for longer than the normal time after birth." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012022 ; owl:annotatedTarget "A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anti-convulsive agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012023 ; owl:annotatedTarget "Elevated concentration of galactose in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012023 ; owl:annotatedTarget "Increased urinary galactose level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anticonvulsants" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:34065827" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anticonvulsive agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012024 ; owl:annotatedTarget "Elevated concentration of galactose in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012025 ; owl:annotatedTarget "Deviation from the normal concentration of ornithine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "anticonvulsive agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "antiepileptic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012026 ; owl:annotatedTarget "Increased concentration of ornithine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012026 ; owl:annotatedTarget "High blood ornithine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "antiepileptics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012027 ; owl:annotatedTarget "An abnormal accumulation of fluid and swelling in the tissues of the larynx." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012027 ; owl:annotatedTarget "Laryngeal oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012028 ; owl:annotatedTarget "A benign tumor of the liver of presumably epithelial origin." . [] a owl:Axiom ; rdfs:label "hepatocellular adenoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012028 ; owl:annotatedTarget "MPATH:353" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "antiepileptique" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012029 ; owl:annotatedTarget "An abnormal concentration of a hormone in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35623 ; owl:annotatedTarget "antiepileptiques" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012030 ; owl:annotatedTarget "Abnormally increased concentration of cortisol in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012030 ; owl:annotatedTarget "High urine cortisol level" . [] a owl:Axiom ; rdfs:label "lipomatous tumor" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012031 ; owl:annotatedTarget "MPATH:415" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012031 ; owl:annotatedTarget "Lipomatous tumour" . [] oboInOwl:hasDbXref "MPATH:417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012032 ; owl:annotatedTarget "Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous." . [] a owl:Axiom ; rdfs:label "Lipoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012032 ; owl:annotatedTarget "MEDDRA:10024612" . [] a owl:Axiom ; rdfs:label "lipoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012032 ; owl:annotatedTarget "MPATH:417" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012032 ; owl:annotatedTarget "Fatty lump" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012032 ; owl:annotatedTarget "Noncancerous fatty lump" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012033 ; owl:annotatedTarget "Presence of a lipoma in the region of the sacrum." . [] oboInOwl:hasDbXref "MPATH:418" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012034 ; owl:annotatedTarget "Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_356416 ; owl:annotatedTarget "PMID:14667225" . [] a owl:Axiom ; rdfs:label "Liposarcoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012034 ; owl:annotatedTarget "MPATH:418" . [] oboInOwl:hasDbXref , "PMID:20631281" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012035 ; owl:annotatedTarget "Multiple, localized or widespread, asymptomatic or inflammatory dermal cysts involving the pilosebaceous units. Lesions can appear anywhere on the body, but steatocystoma multiplex is more commonly involved with those areas of the skin with a high density of developed pilosebaceous units (e.g., the axilla, groin, neck, and proximal extremities)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012036 ; owl:annotatedTarget "Wasting of the sternocleidomastoid muscle, the muscle in the anterior part of the neck that acts to flex and rotate the head." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_356416 ; owl:annotatedTarget "5-azaniumyl-4-oxopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012037 ; owl:annotatedTarget "Wasting of the pectoral muscles, i.e., of the pectoralis major and pectoralis minor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012037 ; owl:annotatedTarget "Wasting of pec muscles" . [] oboInOwl:hasDbXref , "PMID:10611102", "PMID:11222329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012038 ; owl:annotatedTarget "Corneal guttata are droplet-like accumulations of non-banded collagen on the posterior surface of Descemet's membrane. The presence of focal thickenings of Descemet's membrane histologically named guttae. Cornea guttata can be easily diagnosed in vivo and ex vivo by means of specular microscopy as it gives dark areas where no endothelial cells are visible." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012039 ; owl:annotatedTarget "Presence of folds in the Descemet membrane, which is the basement membrane of the endothelial (inner) cell layer of the cornea. Descemet membrane folds are generally a manifestation of inflammation or edema of the cornea." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_356416 ; owl:annotatedTarget "5-aminolevulinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012040 ; owl:annotatedTarget "Abnormal accumulation of fluid and swelling of the stroma of cornea." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012040 ; owl:annotatedTarget "Corneal stromal oedema" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012041 ; owl:annotatedTarget "Decreased fertility in males" . [] oboInOwl:hasDbXref "PMID:12743549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012042 ; owl:annotatedTarget "A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012042 ; owl:annotatedTarget "Aspirin-induced asthma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012043 ; owl:annotatedTarget "Rhythmic, involuntary sinusoidal oscillations of one or both eyes. The waveform of pendular nystagmus may occur in any direction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012043 ; owl:annotatedTarget "Nystagmus, continuous pendular" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012043 ; owl:annotatedTarget "Nystagmus, pendular" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012044 ; owl:annotatedTarget "Seesaw nystagmus is a type of pendular nystagmus where a half cycle consists of the elevation and intorsion of one eye, concurrently with the depression and extortion of the fellow eye. In the other half cycle, there is an inversion of the ocular movements." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:34071686" . [] oboInOwl:hasDbXref "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_356416 ; owl:annotatedTarget "5-ammonio-4-oxopentanoate" . [] oboInOwl:hasDbXref "PMID:7952338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012045 ; owl:annotatedTarget "Presence of multiple yellowish-white lesions of various size and configuration on the retina not related to vascular lesions." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_356416 ; owl:annotatedTarget "5-ammonio-4-oxovalerate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012046 ; owl:annotatedTarget "Inability to elicit tendon reflexes in the upper limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012047 ; owl:annotatedTarget "A visual defect characterized by the inability to see as clearly in bright light as in dim light. The word hemeralopia literally means day blindness." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012047 ; owl:annotatedTarget "Day blindness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012048 ; owl:annotatedTarget "A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012049 ; owl:annotatedTarget "A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012050 ; owl:annotatedTarget "An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012050 ; owl:annotatedTarget "Extreme generalised oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012050 ; owl:annotatedTarget "Extreme generalized edema" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "PMID:1464741" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012051 ; owl:annotatedTarget "Hypoglycermia following a meal (or more generally, after intake of glucose)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012051 ; owl:annotatedTarget "Low blood sugar after a meal" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "PMID:15531285" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012052 ; owl:annotatedTarget "A reduced concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "PMID:20467214" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012053 ; owl:annotatedTarget "A reduced concentration of calcifediol in the blood. Calcifediol is also known as calcidiol, 25-hydroxycholecalciferol and 25-Hydroxyvitamin D3." . [] oboInOwl:hasDbXref , "PMID:22557869" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012054 ; owl:annotatedTarget "Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012055 ; owl:annotatedTarget "Malignant tumor of melanocytes of the ciliary body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012056 ; owl:annotatedTarget "The presence of a melanoma of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012057 ; owl:annotatedTarget "A type of melanoma that is flat and irregular in shape and color, with different shades of black and brown." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "HMG-CoA reductase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012058 ; owl:annotatedTarget "A type of melanoma that starts as a raised area that is usually dark blackish-blue or bluish-red but may not have any color." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012059 ; owl:annotatedTarget "A subtype of melanoma in situ that typically develops on sun-damaged skin. The lesion is typically a large, irregularly pigmented macule that has developed from an ordinary lentigo (a small pigmented spot on the skin with a clearly-defined edge). Change to a malignant lentigo typically takes place over 20 years or more, and many patients accept the change as a consequence of aging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012060 ; owl:annotatedTarget "A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discoloured skin and usually displays a size above 6 mm and often several centimetres or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012061 ; owl:annotatedTarget "Excretion of oligosaccharides conjugated to sialic acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012062 ; owl:annotatedTarget "A fluid filled cavity that develops with a bone." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012062 ; owl:annotatedTarget "Bone cyst" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012062 ; owl:annotatedTarget "Bone cysts" . [] oboInOwl:hasDbXref , "PMID:22474093", "PMID:7863874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012063 ; owl:annotatedTarget "Radiographic features include a dilated, radiolucent lesion typically located eccentrically within the metaphyseal portion of the bone, with fluid levels visible on magnetic resonance imaging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012064 ; owl:annotatedTarget "A benign fluid filled simple cyst of bone filled with serous fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012065 ; owl:annotatedTarget "Presence of multiple cystic changes in multiple areas or multiple bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "HMG-CoA reductase inhibitors" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012065 ; owl:annotatedTarget "Multiple bony cystic lesions" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "hydroxymethylglutaryl-CoA reductase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012066 ; owl:annotatedTarget "Increased concentration of disaccharide in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35664 ; owl:annotatedTarget "hydroxymethylglutaryl-CoA reductase inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012067 ; owl:annotatedTarget "Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012067 ; owl:annotatedTarget "High urine glycopeptide levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012068 ; owl:annotatedTarget "Excretion of excess amounts of aspartylglucosamine in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012068 ; owl:annotatedTarget "High urine aspartylglucosamine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012069 ; owl:annotatedTarget "An increased concentration of keratan sulfate in the urine." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:34102274" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipemics" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012069 ; owl:annotatedTarget "Keratan sulphate excretion in urine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidaemic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012070 ; owl:annotatedTarget "An increased concentration of chondroitin sulfate (CHEBI:37397) in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012070 ; owl:annotatedTarget "Chondroitin sulphate excretion in urine" . [] oboInOwl:hasDbXref , "PMID:18281923", "PMID:23258903", "PMID:6348429" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012071 ; owl:annotatedTarget "Any deviation from the normal concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012072 ; owl:annotatedTarget "Excretion of urine with an acid pH, i.e., having an increased hydrogen ion concentration." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012072 ; owl:annotatedTarget "Acidic urine" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidaemic agents" . [] oboInOwl:hasDbXref , "PMID:10870848" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012073 ; owl:annotatedTarget "An abnormal distribution of N-acylglycines in the urine. There are numerous different N-acylglycines, and this term refers to pathological alterations in their level or distribution." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012074 ; owl:annotatedTarget "An abnormality of the pupillary light reaction characterized by a marked slowing of the light reaction of usually just one pupil. The pupil tends to be relatively dilated, and there is reduced accommodation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidaemic drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012075 ; owl:annotatedTarget "An abnormality of mental functioning affecting the personality and behavioural tendencies of an individual and characterized by a rigid and unhealthy pattern of thinking and behavior. The definition of a personal disorder implies that the abnormality is not the result of damage or insult to the brain or from another psychiatric disorder." . [] a owl:Axiom ; rdfs:label "Specific personality disorders" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012075 ; owl:annotatedTarget "ICD-10:F60" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012076 ; owl:annotatedTarget "A personality disorder characterized by impulsive behavior and unpredictable and capricious mood. Affected individuals show a liability to outbursts of emotion and an incapacity to control the behavioural explosions." . [] a owl:Axiom ; rdfs:label "Emotionally unstable personality disorder, borderline type" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012076 ; owl:annotatedTarget "ICD-10:F60.3" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012076 ; owl:annotatedTarget "BPD" . [] oboInOwl:hasDbXref "ICD-10:F60.4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012077 ; owl:annotatedTarget "A personality disorder characterized by shallow and labile affectivity, self-dramatization, theatricality, exaggerated expression of emotions, suggestibility, egocentricity, self-indulgence, lack of consideration for others, easily hurt feelings, and continuous seeking for appreciation, excitement and attention." . [] a owl:Axiom ; rdfs:label "Histrionic personality disorder" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012077 ; owl:annotatedTarget "ICD-10:F60.4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012078 ; owl:annotatedTarget "Blockade of impulses at a focal site along the course of a motor axon." . [] oboInOwl:hasDbXref , "PMID:3572430" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012079 ; owl:annotatedTarget "Any anomaly of the conduction of motor nerve impulses in the central nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012080 ; owl:annotatedTarget "Atrophy of the cerebellum affecting primarily the granular cell layer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidaemic drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012081 ; owl:annotatedTarget "An abnormally increased size of the cerebellum compared to other brain structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012082 ; owl:annotatedTarget "Atrophy of the cerebellum affecting primarily the Purkinje cell layer." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012083 ; owl:annotatedTarget "Nuclear or cytoplasmic aggregates that show positive staining with antibodies against ubiquitin within cells of the brain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012084 ; owl:annotatedTarget "Any abnormality of the size of the skeletal muscle cell." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012084 ; owl:annotatedTarget "Abnormality of skeletal muscle fibre size" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemic agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemic agents" . [] oboInOwl:hasDbXref , "PMID:25760357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012085 ; owl:annotatedTarget "The presence of 10 or more white cells per cubic millimeter in a urine specimen, 3 or more white cells per high-power field of unspun urine, a positive result on Gram staining of an unspun urine specimen, or a urinary dipstick test that is positive for leukocyte esterase." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012085 ; owl:annotatedTarget "High urine neutrophil count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012086 ; owl:annotatedTarget "An abnormal color of the urine, that is, the color of the urine appears different from the usual straw-yellow color." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemic drug" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012086 ; owl:annotatedTarget "Abnormal urinary color" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012086 ; owl:annotatedTarget "Abnormal urinary colour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012086 ; owl:annotatedTarget "Abnormal urine color" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012086 ; owl:annotatedTarget "Abnormal urine colour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemic drugs" . [] oboInOwl:hasDbXref , "MP:0011633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012087 ; owl:annotatedTarget "An anomaly in the surface contour of mitochondria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012088 ; owl:annotatedTarget "A deviation from the normal odor of the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012088 ; owl:annotatedTarget "Abnormal urinary odor" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012088 ; owl:annotatedTarget "Abnormal urinary odour" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012088 ; owl:annotatedTarget "Abnormal urine smell" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012089 ; owl:annotatedTarget "Arterial inflammation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012089 ; owl:annotatedTarget "Inflammation of artery" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:6317292" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antihyperlipidemics" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012090 ; owl:annotatedTarget "Abnormally shaped pancreas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antilipemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012091 ; owl:annotatedTarget "An anomaly of the function of the pancreas." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antilipemic drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012092 ; owl:annotatedTarget "A functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012092 ; owl:annotatedTarget "Abnormal exocrine pancreatic function" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "antilipemics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012093 ; owl:annotatedTarget "A function abnormality of the endocrine pancreas." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012094 ; owl:annotatedTarget "A deviation from the normal size of the pancreas." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012094 ; owl:annotatedTarget "Abnormal pancreas size" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "hypolipidemic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012095 ; owl:annotatedTarget "Dislocation of many joints." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012095 ; owl:annotatedTarget "Multiple joint dislocations" . [] oboInOwl:hasDbXref , "PMID:16714456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012096 ; owl:annotatedTarget "A congenital inclusion cysts that arises from ectodermal cells that normally form skin cells being left behind in the nervous system during development." . [] oboInOwl:hasDbXref , "PMID:16714456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012097 ; owl:annotatedTarget "A congenital inclusion cysts that arises from the inclusion of ectodermally committed cells at the time of neural tube closure (3rd-5th week of embryogenesis). The capsule of dermoid cysts consists of simple epithelium supported by collagen. In thicker parts, the lining is supplemented with dermis containing hair follicles, sebaceous glands, and apocrine glands." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012098 ; owl:annotatedTarget "An abnormal accumulation of fluid beneath the skin on the back of the feet." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012098 ; owl:annotatedTarget "Oedema of dorsum of feet" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012098 ; owl:annotatedTarget "Oedema of the dorsum of feet" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "hypolipidemic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012099 ; owl:annotatedTarget "An abnormal catecholamine concentration in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "lipid-lowering agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "lipid-lowering agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012100 ; owl:annotatedTarget "An abnormal concentration of creatinine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012100 ; owl:annotatedTarget "Abnormal blood creatinine level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012100 ; owl:annotatedTarget "Creatinine levels abnormal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "lipid-lowering drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012101 ; owl:annotatedTarget "An abnormally reduced amount of creatinine in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012101 ; owl:annotatedTarget "Decreased serum creatinine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012101 ; owl:annotatedTarget "Low blood creatinine level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012101 ; owl:annotatedTarget "Reduced creatinine levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35679 ; owl:annotatedTarget "lipid-lowering drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012102 ; owl:annotatedTarget "A deviation from the normal number of mitochondria per cell." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:7224729" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35681 ; owl:annotatedTarget "Secondary alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012103 ; owl:annotatedTarget "An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012103 ; owl:annotatedTarget "Mitochondrial abnormalities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012104 ; owl:annotatedTarget "Atrophy of the parietal cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012105 ; owl:annotatedTarget "Atrophy of the occipital cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012106 ; owl:annotatedTarget "Disproportionate shortening of the proximal segment of the leg (i.e. the femur)." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35681 ; owl:annotatedTarget "R-CHOH-R'" . [] oboInOwl:hasDbXref , "MP:0008159" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012107 ; owl:annotatedTarget "Increased width of the cross sectional diameter of the fibula." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012107 ; owl:annotatedTarget "Wide calf bone" . [] oboInOwl:hasDbXref , "PMID:11815354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012108 ; owl:annotatedTarget "A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure," . [] oboInOwl:hasDbXref , , "PMID:11815354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012109 ; owl:annotatedTarget "A type of glaucomatous optic neuropathy in an eye that has evidence of angle closure (i.e. significant iridotrabecular contact)." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35681 ; owl:annotatedTarget "a secondary alcohol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012110 ; owl:annotatedTarget "Underdevelopment of the pons." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35681 ; owl:annotatedTarget "secondary alcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012111 ; owl:annotatedTarget "An abnormality of the concentration of a glucocorticoid in the blood." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35692 ; owl:annotatedTarget "Dicarboxylic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012112 ; owl:annotatedTarget "An abnormality of the concentration of corticosterone in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012113 ; owl:annotatedTarget "A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarly for muscle cells." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012113 ; owl:annotatedTarget "Abnormality of creatine metabolism" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35692 ; owl:annotatedTarget "dicarboxylic acids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012113 ; owl:annotatedTarget "Creatine metabolism abnormal" . [] oboInOwl:hasDbXref , "NCIT:C7558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012114 ; owl:annotatedTarget "A carcinoma of the endometrium, the mucous lining of the uterus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012115 ; owl:annotatedTarget "Inflammation of the liver." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012115 ; owl:annotatedTarget "Liver inflammation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35693 ; owl:annotatedTarget "dicarboxylic acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012116 ; owl:annotatedTarget "Deviation from normal concentration of albumin in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012116 ; owl:annotatedTarget "Abnormal albumin level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35693 ; owl:annotatedTarget "dicarboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012117 ; owl:annotatedTarget "Elevation in the concentration of albumin in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:74611" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35695 ; owl:annotatedTarget "dicarboxylic acid monoanions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012117 ; owl:annotatedTarget "High albumin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012117 ; owl:annotatedTarget "High blood albumin levels" . [] oboInOwl:hasDbXref , "NCIT:C4855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012118 ; owl:annotatedTarget "A carcinoma of the larynx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012119 ; owl:annotatedTarget "Abnormally increased levels of methemoglobin in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35701 ; owl:annotatedTarget "Ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012120 ; owl:annotatedTarget "Increased concentration of methylmalonic acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012120 ; owl:annotatedTarget "High blood methylmalonic acid levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012121 ; owl:annotatedTarget "Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012122 ; owl:annotatedTarget "Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012123 ; owl:annotatedTarget "Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35701 ; owl:annotatedTarget "esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012123 ; owl:annotatedTarget "Choroiditis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012124 ; owl:annotatedTarget "Inflammation of the uveal tract in which the primary site of inflammation is the vitreous." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012125 ; owl:annotatedTarget "A cancer of the prostate." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012126 ; owl:annotatedTarget "A cancer arising in any part of the stomach." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35703 ; owl:annotatedTarget "Xenobiotic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012127 ; owl:annotatedTarget "Increased concentration of uracil in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012127 ; owl:annotatedTarget "High urine uracil levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35703 ; owl:annotatedTarget "xenobiotic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012128 ; owl:annotatedTarget "Death of cells in the basal ganglia." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35703 ; owl:annotatedTarget "xenobiotics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012130 ; owl:annotatedTarget "An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35703 ; owl:annotatedTarget "xenobiotic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012131 ; owl:annotatedTarget "A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012132 ; owl:annotatedTarget "Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012132 ; owl:annotatedTarget "Bone marrow biopsy shows erythroid hyperplasia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35718 ; owl:annotatedTarget "antifungal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012132 ; owl:annotatedTarget "Bone marrow smear shows erythroid hyperplasia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012133 ; owl:annotatedTarget "Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012133 ; owl:annotatedTarget "Erythroid hypoplasia in the bone marrow" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35718 ; owl:annotatedTarget "antifungal agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012135 ; owl:annotatedTarget "An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35718 ; owl:annotatedTarget "antifungal drug" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:7836930" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35718 ; owl:annotatedTarget "antifungal drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012139 ; owl:annotatedTarget "Decreased number of granulocyte precursors in the bone marrow." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35718 ; owl:annotatedTarget "antifungals" . [] oboInOwl:hasDbXref , "PMID:19079631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012142 ; owl:annotatedTarget "A subtype of ductal pancreatic carcinoma that is thought to originate from squamous metaplasia of pancreatic ductal epithelium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35722 ; owl:annotatedTarget "glycosaminoglycan sulfate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35722 ; owl:annotatedTarget "glycosaminoglycan sulfates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012146 ; owl:annotatedTarget "Decreased quantity or activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012147 ; owl:annotatedTarget "Decreased quantity of von Willebrand factor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012148 ; owl:annotatedTarget "Myelodysplasia with dysplastic changes in two or more of the myeloid lineages: erythroid, granulocytic, megakaryocytic." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012149 ; owl:annotatedTarget "Myelodysplasia with dysplastic changes in two of the myeloid lineages: erythroid, granulocytic, megakaryocytic." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35722 ; owl:annotatedTarget "sulfated glycosaminoglycans" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012150 ; owl:annotatedTarget "Abnormality/dysplasia of a single myeloid cell (erythroid, granulocytic, or megakaryocytic)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012151 ; owl:annotatedTarget "The presence of blood in the pleural space." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012152 ; owl:annotatedTarget "Splitting of the retinal layers in the macula." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35724 ; owl:annotatedTarget "carbohydrate sulfates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012153 ; owl:annotatedTarget "An decrease in the level of triglycerides in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012153 ; owl:annotatedTarget "Decreased circulating Tg levels" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012153 ; owl:annotatedTarget "Decreased plasma Tg levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012153 ; owl:annotatedTarget "Low blood triglyceride levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012154 ; owl:annotatedTarget "Inability to experience pleasure activities usually found enjoyable." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012155 ; owl:annotatedTarget "Reduced ability of the cornea to respond to stimulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35724 ; owl:annotatedTarget "carbohydrate sulphates" . [] oboInOwl:hasDbXref , "PMID:25328776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012156 ; owl:annotatedTarget "Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues." . [] oboInOwl:hasDbXref , "PMID:20813998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012157 ; owl:annotatedTarget "Atrophy of the cerebral subcortical white and gray matter, termed subcortical atrophy, reflects loss of nerve cells in the basal ganglia or fibers in the deep white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012158 ; owl:annotatedTarget "A separation (dissection) of the layers of the carotid artery wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012159 ; owl:annotatedTarget "A separation (dissection) of the layers of the internal carotid artery wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012160 ; owl:annotatedTarget "A separation (dissection) of the layers of the intracranial portion of the internal carotid artery wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012161 ; owl:annotatedTarget "A separation (dissection) of the layers of the external carotid artery wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012162 ; owl:annotatedTarget "A separation (dissection) of the layers of the common carotid artery wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012163 ; owl:annotatedTarget "A dilatation (balooning or bulging out of the vessel wall) of a carotid artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012164 ; owl:annotatedTarget "A clinical sign indicating a lapse of posture and is usually manifest by a bilateral flapping tremor at the wrist, metacarpophalangeal, and hip joints." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35735 ; owl:annotatedTarget "dicarboxylic acid monoamides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012165 ; owl:annotatedTarget "A developmental defect resulting in the presence of fewer than the normal number of digits." . [] oboInOwl:hasDbXref , "PMID:20575652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012166 ; owl:annotatedTarget "Repetitive and compulsive picking of skin which results in tissue damage." . [] a owl:Axiom ; rdfs:label "Trichotillomania" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012166 ; owl:annotatedTarget "ICD-10:F63.3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012167 ; owl:annotatedTarget "A phenomenon in which persons repetitively pull out their own hair, resulting in noticeable hair loss." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012169 ; owl:annotatedTarget "Habitual biting of one's own body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012170 ; owl:annotatedTarget "Habitual biting of one's own fingernails." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012170 ; owl:annotatedTarget "Nail-biting" . [] oboInOwl:hasDbXref "PMID:28838622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012171 ; owl:annotatedTarget "Habitual clasping and wringing of the hands in the middle of the body, similar to a hand-washing movement." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012171 ; owl:annotatedTarget "Hand clasping" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012171 ; owl:annotatedTarget "Hand-wringing" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35740 ; owl:annotatedTarget "liposaccharides" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012171 ; owl:annotatedTarget "Handwringing" . [] oboInOwl:hasDbXref , "PMID:9244228" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012173 ; owl:annotatedTarget "An increase in heart rate with standing of 30 beats per minute or more." . [] oboInOwl:hasDbXref , "NCIT:C3058", "PMID:10841526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012174 ; owl:annotatedTarget "A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation." . [] oboInOwl:hasDbXref , "PMID:14976057" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012175 ; owl:annotatedTarget "Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PMID:9276764" . [] oboInOwl:hasDbXref , "PMID:21212348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012176 ; owl:annotatedTarget "An anomaly of the natural killer cell, which is a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors. It also regulates immune responses via cytokine release and direct contact with other cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012176 ; owl:annotatedTarget "Abnormal NK cells" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35741 ; owl:annotatedTarget "PMID:18606873" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012177 ; owl:annotatedTarget "A functional anomaly of the natural killer cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012178 ; owl:annotatedTarget "Reduced ability of the natural killer cell to function in the adaptive immune response." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "A form of focal dystonia affecting the face and especially the jaw that is induced by the act of speaking. It is an involuntary contraction of the masticatory muscles, resulting in dysarthria or dysphagia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35741 ; owl:annotatedTarget "glycerolipids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "Abnormal craniofacial posture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "Distorted craniofacial posture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "Abnormal craniofacial muscle tone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "Abnormal facial muscle tone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012179 ; owl:annotatedTarget "Facial Dystonia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012180 ; owl:annotatedTarget "A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012181 ; owl:annotatedTarget "Malfunction of a peripheral nerve resulting from mechanical compression of the nerve roots from internal or external causes and leading to a conduction block or axonal loss." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012182 ; owl:annotatedTarget "A squamous cell carcinoma that originates in the oropharnyx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012183 ; owl:annotatedTarget "Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35744 ; owl:annotatedTarget "carbocyclic fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012184 ; owl:annotatedTarget "An elevated concentration of high-density lipoprotein cholesterol (HDL) in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012184 ; owl:annotatedTarget "High blood HDL level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012185 ; owl:annotatedTarget "Injury to the median nerve caused by its entrapment at the wrist as it traverses through the carpal tunnel. Clinically, constrictive median neuropathy is characterized by pain, paresthesia, and weakness in the median nerve distribution of the hand." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012186 ; owl:annotatedTarget "An entrapment neuropathy of the ulnar nerve in the cubital tunnel (in the elbow) characterized by numbness in the ring and little fingers and weakness of the intrinsic muscles in the hand." . [] oboInOwl:hasDbXref , "PMID:18760763" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012187 ; owl:annotatedTarget "Concentration of protoporphyrins in erythrocytes above the upper limit of normal." . [] oboInOwl:hasDbXref , "OMIM:603373" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012188 ; owl:annotatedTarget "Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012189 ; owl:annotatedTarget "A type of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012190 ; owl:annotatedTarget "A type of lymphoma that originates in T-cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012191 ; owl:annotatedTarget "A type of lymphoma that originates in B-cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35753 ; owl:annotatedTarget "tricarboxylic acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012192 ; owl:annotatedTarget "A type of T-cell lymphoma that exhibits malignant infiltration of the skin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012193 ; owl:annotatedTarget "A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012194 ; owl:annotatedTarget "Transient episodes of weakness of the arm, leg, and in some cases the face on one side of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012195 ; owl:annotatedTarget "Uneven rhythm of breathing." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012196 ; owl:annotatedTarget "An abnormal pattern of respiration characterized by cycles of respiration that are increasingly deeper then shallower with possible periods of apnea. Affected patients may display a 10 to 20 second episode of hypoventilation or apnea, followed by respiration of increased depth and frequency over the course of about one minute. The cycle repeats every 45 seconds to 3 minutes." . [] oboInOwl:hasDbXref , "NCIT:C95598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012197 ; owl:annotatedTarget "A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia." . [] oboInOwl:hasDbXref , "PMID:17768394", "PMID:25022750" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012198 ; owl:annotatedTarget "The presence of more than 5 juvenile polyps of the colon. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands." . [] oboInOwl:hasDbXref , "PMID:21912573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012199 ; owl:annotatedTarget "A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs." . [] a owl:Axiom ; rdfs:label "Cluster headache syndrome" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012199 ; owl:annotatedTarget "ICD-10:G44.0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012200 ; owl:annotatedTarget "An anomaly of clotting factor II, which is known as prothrombin, a vitamin K-dependent proenzyme that functions in the blood coagulation cascade." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35753 ; owl:annotatedTarget "tricarboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012202 ; owl:annotatedTarget "An increase in the concentration of bile acid in the blood." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012203 ; owl:annotatedTarget "A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012204 ; owl:annotatedTarget "Recurrent infection involving the vulva, vagina, and adjacent crural areas, whereby the causative agent belongs to the genus Candida." . [] oboInOwl:hasDbXref , "MP:0002686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012205 ; owl:annotatedTarget "Any structural anomaly of the acrosome resulting in a round sperm head." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35757 ; owl:annotatedTarget "Carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012206 ; owl:annotatedTarget "An anomaly of the mobility of ejaculated sperm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012206 ; owl:annotatedTarget "Abnormal sperm motility" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Reaxys:2224724" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35757 ; owl:annotatedTarget "Monocarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012207 ; owl:annotatedTarget "An abnormal reduction in the mobility of ejaculated sperm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012207 ; owl:annotatedTarget "Reduced sperm motility" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012208 ; owl:annotatedTarget "A lack of mobility of ejaculated sperm." . [] oboInOwl:hasDbXref , "PMID:18954903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012209 ; owl:annotatedTarget "Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease of young childhood characterized clinically by overproduction of myelomonocytic cells and by the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012209 ; owl:annotatedTarget "Juvenile myelomonocytic leukaemia" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35757 ; owl:annotatedTarget "a monocarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Any structural anomaly of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Abnormal kidney morphology" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Abnormally shaped kidney" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Kidney malformation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Kidney structure issue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012210 ; owl:annotatedTarget "Structural kidney abnormalities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35757 ; owl:annotatedTarget "monocarboxylates" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012211 ; owl:annotatedTarget "An abnormal functionality of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012211 ; owl:annotatedTarget "Abnormal kidney function" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012211 ; owl:annotatedTarget "Abnormal renal function" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012211 ; owl:annotatedTarget "Kidney function issue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35757 ; owl:annotatedTarget "monocarboxylic acid anions" . [] oboInOwl:hasDbXref , "PMID:25710660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012212 ; owl:annotatedTarget "An abnormally increased or reduced amount of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012212 ; owl:annotatedTarget "Abnormal GFR" . [] oboInOwl:hasDbXref , "PMID:25710660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012213 ; owl:annotatedTarget "An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012213 ; owl:annotatedTarget "Decreased GFR" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012214 ; owl:annotatedTarget "An abnormal rise in the volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012214 ; owl:annotatedTarget "Increased GFR" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012215 ; owl:annotatedTarget "The deposition of calcium phosphate microliths within the seminiferous tubules." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012216 ; owl:annotatedTarget "An entrapment neuropathy of the suprascapular nerve, presenting with shoulder weakness confined to the supraspinatus muscle (this muscle initiates shoulder abduction) or to the infraspinatus (this muscle externally rotates the arm), as well as with pain in the posterior part of the shoulder and upper periscapular region." . [] oboInOwl:hasDbXref , "PMID:11861450" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012217 ; owl:annotatedTarget "The concentration of porphobilinogen in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref , "PMID:11244503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012218 ; owl:annotatedTarget "A type of soft tissue sarcoma with a histological appearance reminiscent of alveoli because of its reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012219 ; owl:annotatedTarget "An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012220 ; owl:annotatedTarget "The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese)." . [] oboInOwl:hasDbXref , "PMID:15265795" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012221 ; owl:annotatedTarget "A type of blistering that affects the skin of the tibial region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012222 ; owl:annotatedTarget "The presence of multiple hemangiomas in the arachnoid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012223 ; owl:annotatedTarget "A breach of the capsule of the spleen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012223 ; owl:annotatedTarget "Ruptured spleen" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012223 ; owl:annotatedTarget "Splenic rupture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012224 ; owl:annotatedTarget "Persistence of immune complexes in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Reduced number of primary teeth." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35780 ; owl:annotatedTarget "Pi" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Failure of development of some deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Failure of development of some primary teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Partial anodontia of deciduous teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Partial anodontia of primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Decreased number of baby teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Decreased number of deciduous teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Decreased number of milk teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Decreased number of primary teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Fewer baby teeth than normal" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Fewer deciduous teeth than normal" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35780 ; owl:annotatedTarget "phosphate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Fewer primary teeth than normal" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Missing some baby teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Missing some milk teeth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012225 ; owl:annotatedTarget "Missing some primary teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012226 ; owl:annotatedTarget "The presence of a teratoma in the ovary." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012227 ; owl:annotatedTarget "Narrowing of the urethra associated with inflammation or scar tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012228 ; owl:annotatedTarget "A type of headache that last hours with continuous pain of mild or moderate intensity, bilateral location, a pressing/tightening (non-pulsating) quality and that is not aggravated by routine physical activity such as walking or climbing stairs." . [] a owl:Axiom ; rdfs:label "Tension-type headache" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012228 ; owl:annotatedTarget "ICD-10:G44.2" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012228 ; owl:annotatedTarget "Tension-type headache" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012229 ; owl:annotatedTarget "An increased white blood cell count in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35780 ; owl:annotatedTarget "phosphate ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012229 ; owl:annotatedTarget "Increased leukocyte count in CSF" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012230 ; owl:annotatedTarget "A type of retinal detachment associated with a retinal tear, that is, with a break in the retina that allows fluid to pass from the vitreous space into the subretinal space between the sensory retina and the retinal pigment epithelium." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012231 ; owl:annotatedTarget "A type of retinal detachment arising from damage to the outer blood-retinal barrier that allows fluid to access the subretinal space and separate the neurosensory retina from the retinal pigment epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012232 ; owl:annotatedTarget "Decreased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012233 ; owl:annotatedTarget "Blood clot formed within muscle tissue following leakage of blood into the tissue." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012233 ; owl:annotatedTarget "IM hematoma" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012233 ; owl:annotatedTarget "Intramuscular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012233 ; owl:annotatedTarget "Intramuscular hematomas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35782 ; owl:annotatedTarget "PPi" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012234 ; owl:annotatedTarget "Marked decrease in the number of granulocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012235 ; owl:annotatedTarget "A type of agranulocytosis related to ingestion of a specific medication." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35782 ; owl:annotatedTarget "diphosphate ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012236 ; owl:annotatedTarget "An increased concentration of chloride in the sweat." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012236 ; owl:annotatedTarget "Elevated sweat Cl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35788 ; owl:annotatedTarget "seco-steroids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012236 ; owl:annotatedTarget "Elevated sweat Cl-" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012236 ; owl:annotatedTarget "Elevated sweat chloride" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35789 ; owl:annotatedTarget "keto steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012237 ; owl:annotatedTarget "An increased concentration of urocanic acid in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012237 ; owl:annotatedTarget "High urine urocanic acid levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35789 ; owl:annotatedTarget "ketosteroids" . [] oboInOwl:hasDbXref , "MP:0009699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012238 ; owl:annotatedTarget "Increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012239 ; owl:annotatedTarget "Absence of transferrin, a protein that transports iron, in the blood." . [] oboInOwl:hasDbXref , "PMID:20691590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012240 ; owl:annotatedTarget "An abnormal increase in intracellular lipid droplets In a muscle. The number and size of these drops can increase with somd disorders of lipid metabolism affecting muscle. See PMID 20691590 for histological images." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35789 ; owl:annotatedTarget "oxo steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012241 ; owl:annotatedTarget "Atrophy of the levator palpebrae superioris, the extraocular muscle that elevates the superior eyelid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35789 ; owl:annotatedTarget "oxosteroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012242 ; owl:annotatedTarget "Atrophy of the superior rectus, the extraocular muscle whose primary function is to elevate the globe." . [] oboInOwl:hasDbXref , "MP:0002160" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012243 ; owl:annotatedTarget "A structural or developmental anomaly of any of the tissues involved in the genital system." . [] oboInOwl:hasDbXref , "MP:0002210" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012244 ; owl:annotatedTarget "Anomaly of primary or secondary sexual development or characteristics." . [] oboInOwl:hasDbXref , "MP:0005652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012245 ; owl:annotatedTarget "Development of the reproductive system is inconsistent with the chromosomal sex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012246 ; owl:annotatedTarget "Reduced ability to control the movement of the eye associated with damage to the third cranial nerve (the oculomotor nerve)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012247 ; owl:annotatedTarget "Anosmia for one particular odor." . [] oboInOwl:hasDbXref , "PMID:23677846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012248 ; owl:annotatedTarget "Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012249 ; owl:annotatedTarget "An electrocardiographic anomaly of the ST segment, which is the segment that connects the QRS complex and the T wave. The ST segment normally has a duration of 80 to 120 ms, is flat and at the same level (isoelectric) as the PR and TP segment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012250 ; owl:annotatedTarget "An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012251 ; owl:annotatedTarget "An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012252 ; owl:annotatedTarget "A structural anomaly of the respiratory system." . [] oboInOwl:hasDbXref , "MP:0010942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012253 ; owl:annotatedTarget "Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." . [] oboInOwl:hasDbXref , "PMID:17272319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012254 ; owl:annotatedTarget "A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones." . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012255 ; owl:annotatedTarget "An anomaly of the dynein arms of motile cilia. This feature is usually appreciated by electron microscopy." . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012256 ; owl:annotatedTarget "Absence of the outer dynein arms of respiratory motile cilia, which normally are situated outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35804 ; owl:annotatedTarget "dihydrogen citrate" . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012257 ; owl:annotatedTarget "Absence of the inner dynein arms of respiratory motile cilia, which normally are situated within the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012258 ; owl:annotatedTarget "Abnormal arrangement of the structures of the axoneme, which is the cytoskeletal structure that forms the inner core of the motile cilium and displays a canonical 9+2 microtubular pattern of motile cilia studded with dynein arms." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012258 ; owl:annotatedTarget "Abnormal axonemal organisation of respiratory motile cilia" . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012259 ; owl:annotatedTarget "Complete absence of the dynein arms of respiratory motile cilia, that is, absence of the inner and the outer dynein arms, which normally are situated inside and outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy." . [] oboInOwl:hasDbXref , "PMID:19200523" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012260 ; owl:annotatedTarget "A structural anomaly of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prostaglandin E2" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35804 ; owl:annotatedTarget "H2cit" . [] oboInOwl:hasDbXref , "MP:0011055" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012261 ; owl:annotatedTarget "Any functional anomaly of the respiratory motile cilia." . [] oboInOwl:hasDbXref , "PMID:19606528", "PMID:20301301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012262 ; owl:annotatedTarget "Any anomaly of the normal motility of motile cilia. Evaluation of ciliary beat frequency and ciliary beat pattern requires high-speed videomicroscopy of freshly obtained ciliary biopsies that are maintained in culture media under controlled conditions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012264 ; owl:annotatedTarget "Absence of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration." . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012265 ; owl:annotatedTarget "A deviation from the normally well coordinated pattern of intracellular and intercellular synchrony of motile cilia. Dyskinetic cilia usually beat out of synchrony relative to neighboring cilia." . [] oboInOwl:hasDbXref , "PMID:17592081" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012266 ; owl:annotatedTarget "A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG." . [] oboInOwl:hasDbXref , "PMID:19606528" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012267 ; owl:annotatedTarget "Absence of the radial spokes of the axoneme of the respiratory cilium." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35804 ; owl:annotatedTarget "H2cit(-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012268 ; owl:annotatedTarget "A liposarcoma that contains myxomatous tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012269 ; owl:annotatedTarget "Any anomaly in the amount of glycogen in muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012270 ; owl:annotatedTarget "A decreased amount of glycogen in muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012271 ; owl:annotatedTarget "Intermittent episodes of increased resistance to the passage of air in the upper airway." . [] oboInOwl:hasDbXref , "PMID:19561994" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012272 ; owl:annotatedTarget "The J wave is a positive convex deflection that occurs at the junction of the QRS complex and ST segment, the J-point." . [] oboInOwl:hasDbXref , "PMID:9878640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012273 ; owl:annotatedTarget "An increase in the combined thickness of the intima and media of the carotid artery." . [] oboInOwl:hasDbXref , "PMID:18678320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012274 ; owl:annotatedTarget "A type of autosomal dominant inheritance involving a gene that is imprinted with paternal silencing." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012275 ; owl:annotatedTarget "A type of autosomal dominant inheritance involving a gene that is imprinted with maternal silencing." . [] oboInOwl:hasDbXref , "PMID:16443118" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012276 ; owl:annotatedTarget "Inflammation of the flexor digitorum tendon, often associated with the Kanavel signs: (i) finger held in slight flexion, (ii) fusiform swelling, (iii) tenderness along the flexor tendon sheath, and (iv) pain with passive extension of the digit." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012276 ; owl:annotatedTarget "Trigger finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35808 ; owl:annotatedTarget "hydrogen citrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012277 ; owl:annotatedTarget "An abnormally reduced concentration of glycine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012277 ; owl:annotatedTarget "Low blood glycine levels" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35808 ; owl:annotatedTarget "Hcit" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012278 ; owl:annotatedTarget "Any deviation from the normal concentration of serine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35808 ; owl:annotatedTarget "Hcit(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012279 ; owl:annotatedTarget "Reduced concentration of serine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012279 ; owl:annotatedTarget "Low blood serine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012280 ; owl:annotatedTarget "A form of amyloidosis that affects the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012281 ; owl:annotatedTarget "Extravasation of chyle into the peritoneal cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012282 ; owl:annotatedTarget "An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012283 ; owl:annotatedTarget "Reduced size of the Distal epiphysis of femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012283 ; owl:annotatedTarget "Small end part of outermost thighbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012284 ; owl:annotatedTarget "Reduced size of the proximal epiphysis of the tibia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012284 ; owl:annotatedTarget "Small end part of innermost shankbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "PMID:18318842" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012284 ; owl:annotatedTarget "Small end part of innermost shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012285 ; owl:annotatedTarget "An abnormal functionality of the hypothalamus." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(15S)-prostaglandin E2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "BCFA" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012286 ; owl:annotatedTarget "Any structural anomaly of the hypothalamus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012286 ; owl:annotatedTarget "Abnormal shape of hypothalamus" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012287 ; owl:annotatedTarget "Decreased secretion of luteinizing hormone-releasing hormone by the hypothalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012288 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "BCFAs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012288 ; owl:annotatedTarget "Head and neck tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012288 ; owl:annotatedTarget "Head and neck tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012289 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012289 ; owl:annotatedTarget "Face tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012289 ; owl:annotatedTarget "Face tumour" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "Branched chain fatty acid" . [] oboInOwl:hasDbXref , "PMID:19858676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "A congenital defect with an abnormal joining of the gums of the upper and lower jaw." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Fusion of gums" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Fusion of the gingiva" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Gingival synechia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Partial fusion of the gums" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Synechia of the gums" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "branched fatty acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012292 ; owl:annotatedTarget "Upper and lower gums fused together" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "branched fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012293 ; owl:annotatedTarget "An abnormal pigmentation pattern of the external genitalia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35819 ; owl:annotatedTarget "branched-chain fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012294 ; owl:annotatedTarget "Abnormality of the occipital bone of the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012295 ; owl:annotatedTarget "Reduced diameter of the middle phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012295 ; owl:annotatedTarget "Slender middle bone of finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "anticholesteremic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012296 ; owl:annotatedTarget "Reduced diameter of the distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012296 ; owl:annotatedTarget "Slender outermost bone of finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "anticholesteremic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012297 ; owl:annotatedTarget "Reduced diameter of the proximal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012297 ; owl:annotatedTarget "Slender innermost bone of finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "anticholesteremic drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012298 ; owl:annotatedTarget "Increased length of the middle phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012298 ; owl:annotatedTarget "Long middle bone of finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012299 ; owl:annotatedTarget "Increased length of the distal phalanx of finger." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012299 ; owl:annotatedTarget "Long outermost bone of finger" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012300 ; owl:annotatedTarget "Failure of the ureter to undergo development." . [] oboInOwl:hasDbXref , "PMID:15105360", "PMID:22516080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012301 ; owl:annotatedTarget "Abnormal transferrin isoform profile consistent with a type II congenital disorder of glycosylation." . [] oboInOwl:hasDbXref , "PMID:27106239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012302 ; owl:annotatedTarget "Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012303 ; owl:annotatedTarget "An anomaly of the arch of aorta." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemic drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012304 ; owl:annotatedTarget "Underdevelopment of the arch of aorta." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012304 ; owl:annotatedTarget "Underdeveloped aortic arch" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012305 ; owl:annotatedTarget "Narrowing or constriction of the aorta localized to the region of the descending trunk of arch of aorta." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemic drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012306 ; owl:annotatedTarget "An anomaly of the process of rib bone formation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012306 ; owl:annotatedTarget "Abnormal maturation of rib bones" . [] oboInOwl:hasDbXref , "PMID:20504305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012307 ; owl:annotatedTarget "Ribs that are increased in width and taper to the posterior ends." . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012308 ; owl:annotatedTarget "Concentration of the complement component C9 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref , "PMID:19690585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012309 ; owl:annotatedTarget "The presence of amyloid deposition in the superficial dermis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "antihypercholesterolemics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012310 ; owl:annotatedTarget "An anomaly in the number of monocytes, which are myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "cholesterol inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012311 ; owl:annotatedTarget "An increased number of circulating monocytes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012311 ; owl:annotatedTarget "High blood monocyte number" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "cholesterol-lowering agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012312 ; owl:annotatedTarget "An decreased number of circulating monocytes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012312 ; owl:annotatedTarget "Low blood monocyte number" . [] oboInOwl:hasDbXref , "PMID:10531070", "PMID:17488856", "PMID:9709182" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012313 ; owl:annotatedTarget "Bony swelling of the distal interphalangeal joint (DIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically." . [] oboInOwl:hasDbXref , "PMID:10531070", "PMID:9709182" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012314 ; owl:annotatedTarget "Bony swelling of the proximal interphalangeal joint (PIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012315 ; owl:annotatedTarget "A neoplasm containing histiocytes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012316 ; owl:annotatedTarget "Any neoplasm composed of fibrous tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "cholesterol-lowering agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012317 ; owl:annotatedTarget "Inflammation of the sacroiliac joint, generally accompanied by lower back pain." . [] oboInOwl:hasDbXref , "PMID:21569290" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012318 ; owl:annotatedTarget "A distinct type of headache characterized by piercing, throbbing, or electric-shock-like chronic pain in the upper neck, back of the head, and behind the ears, usually on one side." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "cholesterol-lowering drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012319 ; owl:annotatedTarget "Lack of skin pigmentation (coloring) of the abdomen." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "cholesterol-lowering drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012320 ; owl:annotatedTarget "Lack of skin pigmentation (coloring) of the arms and legs." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35821 ; owl:annotatedTarget "hypocholesteremic agent" . [] oboInOwl:hasDbXref , "PMID:20847235" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012321 ; owl:annotatedTarget "An increased concentration of 2-hydroxyglutaric acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012322 ; owl:annotatedTarget "Inflammation surrounding hair follicles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012323 ; owl:annotatedTarget "Myoclonus that occurs during the initial phases of sleep." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012324 ; owl:annotatedTarget "A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012324 ; owl:annotatedTarget "Myeloid leukaemia" . [] oboInOwl:hasDbXref "NCIT:C3178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012325 ; owl:annotatedTarget "A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012325 ; owl:annotatedTarget "Chronic myelomonocytic leukaemia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012326 ; owl:annotatedTarget "An anomaly of the celiac artery." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012326 ; owl:annotatedTarget "Abnormal coeliac artery morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012326 ; owl:annotatedTarget "Abnormality of the coeliac artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012327 ; owl:annotatedTarget "Compression of the celiac artery." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012327 ; owl:annotatedTarget "Coeliac artery compression" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012327 ; owl:annotatedTarget "Coeliac axis syndrome" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012328 ; owl:annotatedTarget "An odontogenic tumor of the cementum of tooth." . [] oboInOwl:hasDbXref , "PMID:2644316" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012329 ; owl:annotatedTarget "A vascular tumor of the skin and subcutaneous tissues and characterized by slow angiomatous proliferation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012330 ; owl:annotatedTarget "An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012331 ; owl:annotatedTarget "A structural abnormality of the autonomic nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012332 ; owl:annotatedTarget "A functional abnormality of the autonomic nervous system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012333 ; owl:annotatedTarget "An abnormal regulation of the sweat glands by the sympathetic nervous system associated with abnormal perspiration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012334 ; owl:annotatedTarget "Impairment of bile flow due to obstruction in large bile ducts outside the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012335 ; owl:annotatedTarget "An abnormality of the metabolism of folic acid, which is also known as vitamin B9." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012337 ; owl:annotatedTarget "An anomaly in the processes involved in the maintenance of an internal equilibrium." . [] a owl:Axiom ; rdfs:label "Abnormal homeostasis" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012337 ; owl:annotatedTarget "MP:0001764" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012338 ; owl:annotatedTarget "Any anomaly in the utilization of energy (calories)." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "Beilstein:510011" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012338 ; owl:annotatedTarget "Abnormal energy expenditure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012339 ; owl:annotatedTarget "An increase in the number of calories used per unit time." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012340 ; owl:annotatedTarget "A reduction in the number of calories used per unit time." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012341 ; owl:annotatedTarget "A pituitary prolactin cell adenoma of less than 10 mm diameter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012342 ; owl:annotatedTarget "A pituitary prolactin cell adenoma of more than 10 mm diameter." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "CAS:90-64-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012343 ; owl:annotatedTarget "Abnormally reduced concentration of ferritin, a ubiquitous intracellular protein that stores iron, in the blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012343 ; owl:annotatedTarget "Decreased serum ferritin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012343 ; owl:annotatedTarget "Low ferritin level" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012343 ; owl:annotatedTarget "Reduced serum ferritin" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "CAS:90-64-2" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012344 ; owl:annotatedTarget "Isolated patches of hardened skin (scleroderma)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012345 ; owl:annotatedTarget "An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "Drug_Central:1629" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012346 ; owl:annotatedTarget "An anomaly of a protein glycosylation process, i.e., of a protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "Gmelin:218213" . [] oboInOwl:hasDbXref , "PMID:22516080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012347 ; owl:annotatedTarget "An anomaly of protein N-linked glycosylation, i.e., an abnormality of the protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a nitrogen atom in an amino acid residue in a protein." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012348 ; owl:annotatedTarget "A reduction in the amount of galactose residues of N-glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012349 ; owl:annotatedTarget "An anomaly of the addition of sialic acids to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012350 ; owl:annotatedTarget "Decreased addition of sialic acids to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012351 ; owl:annotatedTarget "Increased addition of sialic acids to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012352 ; owl:annotatedTarget "An anomaly of the addition of fucose sugar units to N-linked glycans." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012353 ; owl:annotatedTarget "Decreased addition of fucose sugar units to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012354 ; owl:annotatedTarget "Increased addition of fucose sugar units to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012355 ; owl:annotatedTarget "An anomaly of the addition of mannose to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012356 ; owl:annotatedTarget "Reduced addition of mannose to N-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012357 ; owl:annotatedTarget "Increased addition of mannose to N-linked glycans." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "PMID:24278065" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012358 ; owl:annotatedTarget "An anomaly of protein O-linked glycosylation, i.e., of the process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of a serine or threonine residue." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "PMID:4813698" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012359 ; owl:annotatedTarget "An anomaly of the addition of fucose sugar units to O-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012360 ; owl:annotatedTarget "A reduction of the addition of fucose sugar units to O-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012361 ; owl:annotatedTarget "Increased addition of fucose sugar units to O-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012362 ; owl:annotatedTarget "An anomaly of the addition of sialic acids to O-linked glycans." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012363 ; owl:annotatedTarget "An reduced addition of sialic acids to O-linked glycans." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "Reaxys:510011" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012364 ; owl:annotatedTarget "A decreased concentration of potassium(1+) in the urine." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012364 ; owl:annotatedTarget "Decreased urinary K" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012364 ; owl:annotatedTarget "Low urine potassium levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "hydroxy(phenyl)acetic acid" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "(RS)-Mandelic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012365 ; owl:annotatedTarget "An abnormally decreased phosphate concentration in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012365 ; owl:annotatedTarget "Low urine phosphate levels" . [] oboInOwl:hasDbXref , "PMID:10084535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012366 ; owl:annotatedTarget "Projection of the tip of the dens more than 5 mm above a line joining the hard palate to the posterior lip of the foramen magnum (Chamberlain's line) or the tip of the dens is greater than 7 mm above McGregor's line (the back of the hard palate to the lowest point of the occipital squama)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012367 ; owl:annotatedTarget "Bony defects situated along the cranial suture lines or at the junction of the bone plates of the skull." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "2-Hydroxy-2-phenylacetic acid" . [] oboInOwl:hasDbXref "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012368 ; owl:annotatedTarget "Absence of concavity or convexity of the face when viewed in profile." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012368 ; owl:annotatedTarget "Flat face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012368 ; owl:annotatedTarget "Flat facial profile" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012368 ; owl:annotatedTarget "Flat facial shape" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012368 ; owl:annotatedTarget "Flat facies" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "2-Hydroxy-2-phenylethanoic acid" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Large or prominent malar surface of the zygomatic bone of the skull, which is convex and forms the prominence of the 'cheek bones'." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Cheekbone excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Zygomatic bone excess" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Malar hypertrophy" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Prominence of cheekbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Pronounced cheekbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Hyperplasia of cheekbone" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "DL-Mandelic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Hyperplasia of zygomatic bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012370 ; owl:annotatedTarget "Zygomatic hypertrophy" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "Mandelsaeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Big midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Large midface" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Midface hyperplasia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Midfacial excess" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Midfacial prominence" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Hypertrophy of midface" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012371 ; owl:annotatedTarget "Overgrowth of the midface" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35825 ; owl:annotatedTarget "alpha-hydroxybenzeneacetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012372 ; owl:annotatedTarget "A structural anomaly of the globe of the eye, or bulbus oculi." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012372 ; owl:annotatedTarget "Abnormal eye structure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012372 ; owl:annotatedTarget "Abnormally shaped eye" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012373 ; owl:annotatedTarget "A functional anomaly of the eye." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012373 ; owl:annotatedTarget "Abnormal eye physiology" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012375 ; owl:annotatedTarget "Edema (swelling) of the bulbar conjunctiva." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012376 ; owl:annotatedTarget "Abnormal smallness of the lens." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012376 ; owl:annotatedTarget "Small lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012377 ; owl:annotatedTarget "Partial or complete loss of vision in one half of the visual field of one or both eyes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35868 ; owl:annotatedTarget "hydroxy acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012378 ; owl:annotatedTarget "A subjective feeling of tiredness characterized by a lack of energy and motivation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012378 ; owl:annotatedTarget "Fatigue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012378 ; owl:annotatedTarget "Tired" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012378 ; owl:annotatedTarget "Tiredness" . [] oboInOwl:hasDbXref , "MP:0005584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012379 ; owl:annotatedTarget "Concentration or activity of an enzyme is above or below the limits of normal in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35868 ; owl:annotatedTarget "hydroxy monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012380 ; owl:annotatedTarget "Reduced carnitine O-palmitoyltransferase level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012381 ; owl:annotatedTarget "A delay in the development of skills required to feed oneself in the toddler period (between one and three years of age)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012382 ; owl:annotatedTarget "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the left side of the heart to the right." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012383 ; owl:annotatedTarget "Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from both right side of the heart to the left and vice versa." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012384 ; owl:annotatedTarget "Inflammation of the nasal mucosa with nasal congestion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012384 ; owl:annotatedTarget "Nasal inflammation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012385 ; owl:annotatedTarget "The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers or toes cannot be extended to 180 degrees by either active or passive extension." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012385 ; owl:annotatedTarget "Permanent flexion of the finger or toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012386 ; owl:annotatedTarget "Aplasia of the hallux, that is, a development defect such that the big toe does not develop." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012386 ; owl:annotatedTarget "Absent big toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012386 ; owl:annotatedTarget "Missing big toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012387 ; owl:annotatedTarget "Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012388 ; owl:annotatedTarget "Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012389 ; owl:annotatedTarget "Muscular hypotonia of one or more limbs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35871 ; owl:annotatedTarget "oxo monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012390 ; owl:annotatedTarget "A small tear in the thin, moist tissue (mucosa) that lines the anus. It appears as a crack or slit in the mucous membrane of the anus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35875 ; owl:annotatedTarget "imidazopyrimidines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012391 ; owl:annotatedTarget "Reduced intensity of muscle tendon reflexes in the upper limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35881 ; owl:annotatedTarget "pnictogen hydride" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012392 ; owl:annotatedTarget "Reduced intensity of muscle tendon reflexes in jaw." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012392 ; owl:annotatedTarget "Mandibular hyporeflexia" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012393 ; owl:annotatedTarget "An allergy is an immune response or reaction to substances that are usually not harmful." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012393 ; owl:annotatedTarget "Allergy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012394 ; owl:annotatedTarget "Allergy to iodine contrast media used in radiological studies." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012395 ; owl:annotatedTarget "An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35881 ; owl:annotatedTarget "pnictogen hydrides" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012395 ; owl:annotatedTarget "Seasonal allergy" . [] oboInOwl:hasDbXref , "PMID:12095476" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012396 ; owl:annotatedTarget "A motility disorder characterized by biliary colic in the absence of gallstones with a reduced gallbladder ejection fraction." . [] oboInOwl:hasDbXref , "PMID:16818829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012397 ; owl:annotatedTarget "The presence of atheromas or atherosclerotic plaques in the aorta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012397 ; owl:annotatedTarget "Plaque build-up in aorta artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012398 ; owl:annotatedTarget "An abnormal accumulation of interstitial fluid in the soft tissues of the limbs." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012398 ; owl:annotatedTarget "Peripheral oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012399 ; owl:annotatedTarget "A type of ulcer that is caused when an area of skin is subject to pressure over a prolonged period of time, ranging in range in severity from patches of discolored skin to open wounds that expose the underlying bone or muscle. The most common sites are the sacrum, coccyx, heels and the hips." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012399 ; owl:annotatedTarget "Bedsore" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012399 ; owl:annotatedTarget "Pressure Sore" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012399 ; owl:annotatedTarget "Pressure ulcer" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012400 ; owl:annotatedTarget "An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate." . [] oboInOwl:hasDbXref "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "(Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35902 ; owl:annotatedTarget "oxo monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012401 ; owl:annotatedTarget "A deviation from normal of the concentration of 2-oxoglutaric acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012402 ; owl:annotatedTarget "A greater than normal concentration of 2-oxoglutaric acid in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012402 ; owl:annotatedTarget "Increased urine alpha-ketoglutarate concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35903 ; owl:annotatedTarget "oxo carboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012403 ; owl:annotatedTarget "A lower than normal concentration of 2-oxoglutaric acid in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012404 ; owl:annotatedTarget "A deviation from normal of the concentration of citrate(3-) in the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012404 ; owl:annotatedTarget "Abnormal urine citrate concentration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012405 ; owl:annotatedTarget "A lower than normal concentration of citrate(3-) in the urine." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35907 ; owl:annotatedTarget "Beilstein:3904478" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012406 ; owl:annotatedTarget "A greater than normal concentration of citrate(3-) in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012407 ; owl:annotatedTarget "A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012407 ; owl:annotatedTarget "Scissor gait" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012407 ; owl:annotatedTarget "Scissor walk" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012407 ; owl:annotatedTarget "Scissors gait" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012408 ; owl:annotatedTarget "The deposition of calcium salts in the parenchyma of the renal medulla (innermost part of the kidney)." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35907 ; owl:annotatedTarget "Gmelin:326031" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012409 ; owl:annotatedTarget "The deposition of calcium salts in the parenchyma of the renal cortex (the outer portion of the kidney between the renal capsule and the renal medulla)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012410 ; owl:annotatedTarget "A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012411 ; owl:annotatedTarget "The onset of growth of pubic hair at an earlier age than normal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012411 ; owl:annotatedTarget "Premature pubic hair growth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012412 ; owl:annotatedTarget "Onset of adrenarche at an earlier age than usual." . [] oboInOwl:hasDbXref "PMID:10414639" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0012412 ; owl:annotatedTarget "Adrenarche is an early sexual maturation stage that typically occurs at around 6 to 8 years of age, during which the adrenal cortex begins to secrete increased levels of androgens resulting from the development of the zona reticularis in the adrenal cortex. Note that pubarche refers to the development of pubic hair, axillary hair, and adult sweat gland (apocrine) odor. The physical features associated with pubarche reflect the onset of adrenarche, which refers to the pubertal maturation of the adrenal and is associated with increased secretion of an adrenal hormone called dehydroepiandrosterone sulfate (DHEAS)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012413 ; owl:annotatedTarget "The presence of a V-shaped indentation (notch) in the primary central incisor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012413 ; owl:annotatedTarget "Notched front baby tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012413 ; owl:annotatedTarget "Notched front deciduous tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012413 ; owl:annotatedTarget "Notched front primary tooth" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_35907 ; owl:annotatedTarget "Reaxys:3904478" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012413 ; owl:annotatedTarget "Syphilitic primary incisor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012414 ; owl:annotatedTarget "Wasting or decrease in size of all or part of the duodenum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35907 ; owl:annotatedTarget "4-carboxybutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012415 ; owl:annotatedTarget "An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012415 ; owl:annotatedTarget "Abnormal blood gas level" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Cervidil" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35907 ; owl:annotatedTarget "hydrogen glutarate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012416 ; owl:annotatedTarget "Abnormally elevated blood carbon dioxide (CO2) level." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012416 ; owl:annotatedTarget "High blood carbon dioxide level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012417 ; owl:annotatedTarget "Abnormally reduced blood carbon dioxide (CO2) level." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35910 ; owl:annotatedTarget "2-oxo carboxylic acids" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/hypocapnia" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012417 ; owl:annotatedTarget "Hypocarbia" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/hypocapnia" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012417 ; owl:annotatedTarget "Reduced carbon dioxide in the blood" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35910 ; owl:annotatedTarget "2-Oxo acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012418 ; owl:annotatedTarget "An abnormally low level of blood oxygen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012418 ; owl:annotatedTarget "Low blood oxygen level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012418 ; owl:annotatedTarget "Hypoxia" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35910 ; owl:annotatedTarget "2-Oxocarboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012419 ; owl:annotatedTarget "An abnormally high level of blood oxygen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012420 ; owl:annotatedTarget "Amniotic fluid containing the earliest stools of a mammalian infant." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35910 ; owl:annotatedTarget "2-oxo acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012421 ; owl:annotatedTarget "Congenital lack of the skin of prepuce of penis, that is, of the double-layered fold of skin and mucous membrane that covers the glans penis." . [] oboInOwl:hasDbXref , "PMID:16523225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012422 ; owl:annotatedTarget "Overgrowth of the choroid plexus." . [] oboInOwl:hasDbXref , "PMID:23449085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012423 ; owl:annotatedTarget "The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35910 ; owl:annotatedTarget "2-oxo monocarboxylic acids" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_35915 ; owl:annotatedTarget "Sterol ester" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35915 ; owl:annotatedTarget "3-hydroxysteroid ester" . [] oboInOwl:hasDbXref , "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012424 ; owl:annotatedTarget "An inflammation of the choroid and retina." . [] oboInOwl:hasDbXref , "PMID:7065551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012425 ; owl:annotatedTarget "An ulcer of the colon due to pressure and irritation from retained fecal masses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012425 ; owl:annotatedTarget "Colon ulcer" . [] oboInOwl:hasDbXref , "PMID:22787500", "PMID:23658477", "PMID:30524490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012426 ; owl:annotatedTarget "Optic disc drusen are acellular, calcified deposits within the optic nerve head. Optic disc drusen are congenital and developmental anomalies of the optic nerve head, representing hyaline-containing bodies that, over time, appear as elevated, lumpy irregularities on the anterior portion of the optic nerve." . [] oboInOwl:hasDbXref , , "PMID:32579722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012427 ; owl:annotatedTarget "An increased degree of femoral version, which is defined as the angular difference between axis of femoral neck and transcondylar axis of the knee. Thus, femoral anteversion is an inward twisting of the femur that causes the knees and feet to turn inward." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012427 ; owl:annotatedTarget "Internally rotated hips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35915 ; owl:annotatedTarget "3-hydroxysteroid esters" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012428 ; owl:annotatedTarget "Protruding heel bone, or calcaneus." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012428 ; owl:annotatedTarget "Prominent heel bone" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Cerviprime" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35915 ; owl:annotatedTarget "Steryl ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012429 ; owl:annotatedTarget "Absence or underdevelopment of the cerebral white matter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012429 ; owl:annotatedTarget "Absent/small cerebral white matter" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012429 ; owl:annotatedTarget "Absent/underdeveloped cerebral white matter" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35915 ; owl:annotatedTarget "a sterol ester" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012430 ; owl:annotatedTarget "Underdevelopment of the cerebral white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012431 ; owl:annotatedTarget "Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012432 ; owl:annotatedTarget "Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012432 ; owl:annotatedTarget "Chronic extreme exhaustion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35931 ; owl:annotatedTarget "delta-amino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012432 ; owl:annotatedTarget "Chronic fatigue" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012433 ; owl:annotatedTarget "Abnormal social behavior" . [] oboInOwl:hasDbXref , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012433 ; owl:annotatedTarget "Abnormal social behaviour" . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012433 ; owl:annotatedTarget "Abnormal social interactions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012434 ; owl:annotatedTarget "A failure to meet one or more age-related milestones of social behavior." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012434 ; owl:annotatedTarget "Delayed social development" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012435 ; owl:annotatedTarget "Reduction in length of the ventral (lower) skin of prepuce of penis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012436 ; owl:annotatedTarget "Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35942 ; owl:annotatedTarget "neurotransmitter agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012437 ; owl:annotatedTarget "A structural anomaly of the gallbladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012437 ; owl:annotatedTarget "Abnormal gallbladder structure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012437 ; owl:annotatedTarget "Abnormal shape of gallbladder" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35950 ; owl:annotatedTarget "4-oxo acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012438 ; owl:annotatedTarget "A functional anomaly of the gallbladder." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35950 ; owl:annotatedTarget "4-oxo monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012439 ; owl:annotatedTarget "A functional abnormality of the biliary tree." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "3-hydroxy acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012440 ; owl:annotatedTarget "A structural abnormality of the biliary tree." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012441 ; owl:annotatedTarget "Reduced motility through the sphincter of Oddi, resulting in impedance of bile and pancreatic juice flow from the common bile duct into the duodenum." . [] oboInOwl:hasDbXref , "PMID:12095476", "PMID:17761125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012442 ; owl:annotatedTarget "Reduced motility of the gallbladder with reduced emptying fraction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "3-hydroxy monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012443 ; owl:annotatedTarget "A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012443 ; owl:annotatedTarget "Abnormal shape of brain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012443 ; owl:annotatedTarget "Abnormality of the brain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "beta-hydroxy acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012444 ; owl:annotatedTarget "Partial or complete wasting (loss) of brain tissue that was once present." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012444 ; owl:annotatedTarget "Brain degeneration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012444 ; owl:annotatedTarget "Brain wasting" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "beta-hydroxy acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012446 ; owl:annotatedTarget "A reduced concentration of 5-methyltetrahydrofolate(2-) in the cerebrospinal fluid (CSF). 5-methyltetrahydrofolate is the active folate metabolite." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012446 ; owl:annotatedTarget "Reduced CSF 5-methyltetrahydrofolate concentration" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Cerviprost" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "beta-hydroxy carboxylic acid" . [] oboInOwl:hasDbXref , "MP:0000920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012447 ; owl:annotatedTarget "Any anomaly in the process by which myelin sheaths are formed and maintained around neurons." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35969 ; owl:annotatedTarget "beta-hydroxy carboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012448 ; owl:annotatedTarget "Delayed myelination." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012449 ; owl:annotatedTarget "Inflammation of the synovial membrane of the sacroiliac joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012450 ; owl:annotatedTarget "Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012450 ; owl:annotatedTarget "Chronic constipation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012450 ; owl:annotatedTarget "Infrequent bowel movements" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012451 ; owl:annotatedTarget "Constipation of sudden onset and lasting for less than three months." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012452 ; owl:annotatedTarget "A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012452 ; owl:annotatedTarget "Willis-Ekbom disease" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_35972 ; owl:annotatedTarget "dihydroxy monocarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012453 ; owl:annotatedTarget "A chronic loss of wrist joint motion on the right and left sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012454 ; owl:annotatedTarget "A chronic loss of wrist joint motion on one side only." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012456 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the tunica media of arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012457 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the tunica media of medium-sized (muscular or distributive) arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012458 ; owl:annotatedTarget "Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries." . [] oboInOwl:hasDbXref , "PMID:20585827", "PMID:23832130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012459 ; owl:annotatedTarget "A headache disorder that occurs exclusively at night, waking the affected individual from sleep." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012459 ; owl:annotatedTarget "Alarm clock headache" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012460 ; owl:annotatedTarget "A structural anomaly of the inferior portion of the vermis of cerebellum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012461 ; owl:annotatedTarget "The presence of bacteria in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012461 ; owl:annotatedTarget "Bacteria in urine" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012461 ; owl:annotatedTarget "High urine bacteria" . [] oboInOwl:hasDbXref , "PMID:16816905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012462 ; owl:annotatedTarget "Involuntary and irregular twitches of the chin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012463 ; owl:annotatedTarget "An above normal level of saturation of serum transferrin with iron." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36043 ; owl:annotatedTarget "antimicrobial drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012464 ; owl:annotatedTarget "A below normal level of saturation of serum transferrin with iron." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36044 ; owl:annotatedTarget "anti-viral drug" . [] oboInOwl:hasDbXref , "PMID:10922422", "PMID:14668426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012465 ; owl:annotatedTarget "An increased level of iron in liver tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012465 ; owl:annotatedTarget "Increased iron concentration in liver" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012465 ; owl:annotatedTarget "Increased liver iron level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012466 ; owl:annotatedTarget "Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012467 ; owl:annotatedTarget "Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012468 ; owl:annotatedTarget "Longstanding abnormal acid accumulation or depletion of base." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012469 ; owl:annotatedTarget "Infantile spasms represent a subset of \"epileptic spasms\". Infantile Spasms are epileptic spasms starting in the first year of life (infancy)." . [] oboInOwl:hasDbXref , "PMID:17030938" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012470 ; owl:annotatedTarget "An ophthalmologic sign in young children resulting from upward-gaze paresis. In this condition, the eyes appear driven downward, the sclera may be seen between the upper eyelid and the iris, and part of the lower pupil may be covered by the lower eyelid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36044 ; owl:annotatedTarget "anti-virus drug" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012470 ; owl:annotatedTarget "Setting-sun eye phenomenon" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012470 ; owl:annotatedTarget "Sun setting eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012470 ; owl:annotatedTarget "Sunsetting eye" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012470 ; owl:annotatedTarget "Eyes fixed downward" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Increased width of the skin of vermilion border region of upper lip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Full lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Increased volume of lip" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Increased volume of lip vermillion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Plump lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Prominent lips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36044 ; owl:annotatedTarget "antiviral drugs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012471 ; owl:annotatedTarget "Thick lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012472 ; owl:annotatedTarget "A turning outward of the lip or lips, that is, eversion of the lips." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012472 ; owl:annotatedTarget "Everted lips" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012472 ; owl:annotatedTarget "Outward turned lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012473 ; owl:annotatedTarget "Wasting of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012473 ; owl:annotatedTarget "Lingual atrophy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012473 ; owl:annotatedTarget "Lingual wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012473 ; owl:annotatedTarget "Wasting of the tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012474 ; owl:annotatedTarget "Complete obstruction of a carotid artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012474 ; owl:annotatedTarget "Obstructed carotid artery" . [] oboInOwl:hasDbXref , "PMID:17100769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012475 ; owl:annotatedTarget "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against a specific antigen or microorganism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012476 ; owl:annotatedTarget "The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci." . [] oboInOwl:hasDbXref , "PMID:22505778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012477 ; owl:annotatedTarget "A wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012477 ; owl:annotatedTarget "Shakey voice" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012477 ; owl:annotatedTarget "Vocal tremor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Ankylosis of temporomandibular joint" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Freezing of jaw joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Freezing of the temporomandibular joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Rigidity of the temporomandibular joint" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36059 ; owl:annotatedTarget "hydroxy monocarboxylic acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012478 ; owl:annotatedTarget "Adhesion of the temporomandibular joint" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint noise" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint sounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Temporomandibular joint noise" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Temporomandibular joint sounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint crepitus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint clicking sound" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint grating sound" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Jaw joint popping sound" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Dinoproston" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36059 ; owl:annotatedTarget "hydroxymonocarboxylic acid anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Temporomandibular joint clicking sound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Temporomandibular joint grating sound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012479 ; owl:annotatedTarget "Temporomandibular joint popping sound" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36059 ; owl:annotatedTarget "hydroxymonocarboxylic acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012480 ; owl:annotatedTarget "An anomaly of cerebral veins." . [] oboInOwl:hasDbXref , "PMID:8770251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012481 ; owl:annotatedTarget "A congenital malformation of veins which drain normal brain characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012482 ; owl:annotatedTarget "A venous angioma of the frontal lobe of the brain." . [] oboInOwl:hasDbXref , "PMID:8467233" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012483 ; owl:annotatedTarget "Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012484 ; owl:annotatedTarget "Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin." . [] oboInOwl:hasDbXref , "PMID:1760557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012485 ; owl:annotatedTarget "An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36063 ; owl:annotatedTarget "oxytocic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012486 ; owl:annotatedTarget "Inflammation of the spinal cord." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012486 ; owl:annotatedTarget "Inflammation of spinal cord" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012487 ; owl:annotatedTarget "An arachnoid cyst located at the margin of the cerebellum and pons." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36063 ; owl:annotatedTarget "oxytocic agents" . [] oboInOwl:hasDbXref , "PMID:8951893" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012488 ; owl:annotatedTarget "An arachnoid cyst located within the ventricular system." . [] oboInOwl:hasDbXref , "PMID:21586175" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012489 ; owl:annotatedTarget "An arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36063 ; owl:annotatedTarget "oxytocic drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012490 ; owl:annotatedTarget "Inflammation of adipose tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012490 ; owl:annotatedTarget "Inflammation of adipose tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012490 ; owl:annotatedTarget "Inflammation of fat tissue" . [] oboInOwl:hasDbXref , "PMID:1322202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012491 ; owl:annotatedTarget "An anomaly of the intracellular membrane complexes known as the dense tubular system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012492 ; owl:annotatedTarget "Narrowing or constriction of the inner surface (lumen) of a cerebral artery." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012492 ; owl:annotatedTarget "Narrowing of a cerebral artery" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012493 ; owl:annotatedTarget "Narrowing or constriction of the inner surface (lumen) of the middle cerebral artery." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36063 ; owl:annotatedTarget "uterine stimulants" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012494 ; owl:annotatedTarget "Narrowing or constriction of the inner surface (lumen) of the anterior cerebral artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012495 ; owl:annotatedTarget "Narrowing or constriction of the inner surface (lumen) of the posterior cerebral artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012496 ; owl:annotatedTarget "A decrease in the maximum amount of negative pressure a person can generate during an inhalation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012497 ; owl:annotatedTarget "A decrease in the maximum amount of pressure of expired air achieved by a person after a full inspiration." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012498 ; owl:annotatedTarget "A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012499 ; owl:annotatedTarget "A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012500 ; owl:annotatedTarget "A wartlike (with multiple small elevated projections) papule." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012501 ; owl:annotatedTarget "An anomaly of the white matter of brainstem." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36078 ; owl:annotatedTarget "LIPID_MAPS_class:LMST04" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012502 ; owl:annotatedTarget "An anomaly of the internal capsule, which is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the putamen and the globus pallidus." . [] oboInOwl:hasDbXref "LIPID_MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36078 ; owl:annotatedTarget "bile acids and derivatives" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012503 ; owl:annotatedTarget "An anomaly of the pituitary gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012504 ; owl:annotatedTarget "A deviation from the normal size of the pituitary gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36078 ; owl:annotatedTarget "cholanoids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012505 ; owl:annotatedTarget "An abnormally increased size of the pituitary gland." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Enzaprost E" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012506 ; owl:annotatedTarget "An abnormally decreased size of the pituitary gland." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36080 ; owl:annotatedTarget "proteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012507 ; owl:annotatedTarget "Reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012507 ; owl:annotatedTarget "Weakness of orbicularis oculi muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012508 ; owl:annotatedTarget "A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012509 ; owl:annotatedTarget "An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream." . [] oboInOwl:hasDbXref , "PMID:22327705", "PMID:23838695" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012510 ; owl:annotatedTarget "An increased amount of cerebrospinal fluid (CSF) in the subarachnoid space." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012510 ; owl:annotatedTarget "Extra-axial CSF accumulation" . [] oboInOwl:hasDbXref , "PMID:19668477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012511 ; owl:annotatedTarget "A pale yellow discoloration of the temporal (lateral) portion of the optic disc." . [] oboInOwl:hasDbXref , "PMID:19668477" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012512 ; owl:annotatedTarget "A pale yellow discoloration of the entire optic disc." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36141 ; owl:annotatedTarget "quinone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012513 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the arm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012513 ; owl:annotatedTarget "Upper limb pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012514 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012514 ; owl:annotatedTarget "Leg pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012514 ; owl:annotatedTarget "Lower limb pain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36141 ; owl:annotatedTarget "quinones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012515 ; owl:annotatedTarget "Reduced ability to flex the femur, that is, to pull the knee upward." . [] oboInOwl:hasDbXref , "PMID:22368654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012516 ; owl:annotatedTarget "An extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36141 ; owl:annotatedTarget "Chinon" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012517 ; owl:annotatedTarget "An abnormally decreased amount of catalase level." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36141 ; owl:annotatedTarget "quinones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012518 ; owl:annotatedTarget "An anomaly of the circle of Willis, also known as the cerebral arterial circle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012518 ; owl:annotatedTarget "Abnormality of the cerebral arterial circle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012519 ; owl:annotatedTarget "A developmental anomnaly characterized by underdevelopment of the posterior communicating artery." . [] oboInOwl:hasDbXref , "PMID:17620468", "PMID:23867200", "PMID:25564639" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012520 ; owl:annotatedTarget "Increased dimensions of the Virchow-Robin spaces (also known as perivascular spaces), which surround the walls of vessels as they course from the subarachnoid space through the brain parenchyma. Perivascular spaces are commonly microscopic, and not visible on conventional neuroimaging. This term refers to an increase of size of these spaces such that they are visible on neuroimaging (usually magnetic resonance imaging). The dilatations are regular cavities that always contain a patent artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012521 ; owl:annotatedTarget "Congenital absence of the optic nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012521 ; owl:annotatedTarget "Absent optic nerve" . [] oboInOwl:hasDbXref , "PMID:22356347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012522 ; owl:annotatedTarget "A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012523 ; owl:annotatedTarget "Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012524 ; owl:annotatedTarget "A deviation from the normal discoid platelet shape." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012525 ; owl:annotatedTarget "An anomalous location and arrangement of platelet alpha granules." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36145 ; owl:annotatedTarget "oxo dicarboxylic acids" . [] oboInOwl:hasDbXref , "PMID:3877532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012526 ; owl:annotatedTarget "A lack of platelet alpha granules. This typically results in the grey appearance of platelets in giemsa stained blood smears." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012526 ; owl:annotatedTarget "Grey platelets" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012527 ; owl:annotatedTarget "A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012528 ; owl:annotatedTarget "A deviation from the normal count of alpha granules per thrombocyte." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012529 ; owl:annotatedTarget "A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012530 ; owl:annotatedTarget "A deviation from the normal count of dense granules per thrombocyte." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012531 ; owl:annotatedTarget "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012531 ; owl:annotatedTarget "Pain" . [] oboInOwl:hasDbXref , "PMID:1875958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012532 ; owl:annotatedTarget "Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012532 ; owl:annotatedTarget "Chronic pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36147 ; owl:annotatedTarget "oxo dicarboxylates" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012532 ; owl:annotatedTarget "Long-lasting pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012533 ; owl:annotatedTarget "Pain due to a stimulus that does not normally provoke pain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012534 ; owl:annotatedTarget "Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012534 ; owl:annotatedTarget "Dysesthesias" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36147 ; owl:annotatedTarget "oxo-dicarboxylic acid dianion" . [] oboInOwl:hasDbXref , "MP:0003635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012535 ; owl:annotatedTarget "An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process." . [] oboInOwl:hasDbXref , "PMID:1495720", "PMID:9722063" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012536 ; owl:annotatedTarget "The presence of circulating autoantibodies to anticardiolipin in the mother." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012537 ; owl:annotatedTarget "A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012537 ; owl:annotatedTarget "Food intolerance" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012538 ; owl:annotatedTarget "A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012538 ; owl:annotatedTarget "Gluten intolerance" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012538 ; owl:annotatedTarget "Gluten sensitivity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012539 ; owl:annotatedTarget "A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012540 ; owl:annotatedTarget "An epidermoid cyst in the armpit." . [] oboInOwl:hasDbXref "ChEBI" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Glandin-E2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36147 ; owl:annotatedTarget "oxo-dicarboxylic acid dianions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012540 ; owl:annotatedTarget "Armpit cyst" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012541 ; owl:annotatedTarget "Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012542 ; owl:annotatedTarget "Thickened nails without deformity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012543 ; owl:annotatedTarget "The presence of hemosiderin in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012544 ; owl:annotatedTarget "Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012545 ; owl:annotatedTarget "Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref , "PMID:18097476" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012546 ; owl:annotatedTarget "A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012547 ; owl:annotatedTarget "Anomalous movements of the eyes that occur without the subject wanting them to happen." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012548 ; owl:annotatedTarget "Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012549 ; owl:annotatedTarget "A lipoma (a benign tumor composed of adipose tissue) located in the conjunctiva." . [] oboInOwl:hasDbXref , "PMID:16688816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012550 ; owl:annotatedTarget "The presence of varices (enlarged and convoluted blood vessels) in the colon." . [] oboInOwl:hasDbXref , "PMID:6155073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012551 ; owl:annotatedTarget "Lack of specific granules in neutrophils." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012552 ; owl:annotatedTarget "Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012553 ; owl:annotatedTarget "A thumbnail that is diminished in length and width, i.e., underdeveloped thumb nail." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012553 ; owl:annotatedTarget "Small thumbnail" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012553 ; owl:annotatedTarget "Underdeveloped thumbnail" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012554 ; owl:annotatedTarget "Absence of thumb nail." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012555 ; owl:annotatedTarget "Absent nail of big toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012555 ; owl:annotatedTarget "Absent big toe nail" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36149 ; owl:annotatedTarget "hydrogen 2-hydroxypentanedioate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012555 ; owl:annotatedTarget "Absent nail of big toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36164 ; owl:annotatedTarget "amino dicarboxylic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012556 ; owl:annotatedTarget "Increased concentration of beta-alanine in the blood." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012556 ; owl:annotatedTarget "High blood beta-alanine levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012557 ; owl:annotatedTarget "EEG with focal sharp transient waves in the centrotemporal region of the brain (also known as the central sulcus), i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave." . [] oboInOwl:hasDbXref , "PMID:16982586" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012558 ; owl:annotatedTarget "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012559 ; owl:annotatedTarget "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is higher than normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012560 ; owl:annotatedTarget "A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is lower than normal." . [] oboInOwl:hasDbXref , "PMID:18480095", "PMID:20329493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012561 ; owl:annotatedTarget "The presence of an aortic valve with one instead of the normal three cusps (flaps)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012562 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the hand, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "Disaccharide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012563 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the foot, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012564 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the tibia, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012565 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the fibula, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012566 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the radius, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012567 ; owl:annotatedTarget "Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the ulna, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "disaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Edema in the region of the Lower eyelid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Cellulitis of lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Fullness of lower eyelid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Lower eyelid oedema" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Puffiness of lower eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012568 ; owl:annotatedTarget "Swelling of lower eyelid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "Disaccharid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012569 ; owl:annotatedTarget "First period after the age of 15 years." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012569 ; owl:annotatedTarget "Delayed start of first period" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012570 ; owl:annotatedTarget "A type of mesenchymal tissue cell tumor that exhibits epithelial differentiation, which most frequently arises in the extremities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012570 ; owl:annotatedTarget "Malignant synovioma" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012571 ; owl:annotatedTarget "A partial duplication of the ureter where the duplicated ureters fuse to a single ureter before their insertion into the bladder." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "Disacharid" . [] a owl:Axiom ; rdfs:label "Duplication of ureter" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012571 ; owl:annotatedTarget "ICD-10:Q62.5" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012572 ; owl:annotatedTarget "A complete duplication of the ureter, where the duplicated ureters have separate insertions into the bladder." . [] a owl:Axiom ; rdfs:label "Duplication of ureter" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012572 ; owl:annotatedTarget "ICD-10:Q62.5" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012573 ; owl:annotatedTarget "A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Minprositin E2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "disacarido" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:Eurenomics_fschaefer", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012574 ; owl:annotatedTarget "Increased numbers of mesangial cells per glomerulus, defined as more than 3 nuclei fully surrounded by matrix in one or more mesangial areas, not including perihilar region, on a standard 3-micron-thick tissue section, best evaluated on periodic acid-Schiff (PAS) stain." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36233 ; owl:annotatedTarget "disacaridos" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012575 ; owl:annotatedTarget "A structural anomaly of the nephron." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012576 ; owl:annotatedTarget "The presence of complement 3 deposits in the glomerulus." . [] oboInOwl:hasDbXref , , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012577 ; owl:annotatedTarget "Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012578 ; owl:annotatedTarget "A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012579 ; owl:annotatedTarget "The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012580 ; owl:annotatedTarget "The presence of calcium- and phosphate-containing calculi (stones) in the kidneys." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012580 ; owl:annotatedTarget "Ca phosphate nephrolithiasis" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36237 ; owl:annotatedTarget "CAS:25312-65-6" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012580 ; owl:annotatedTarget "Ca phosphate urolithiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012580 ; owl:annotatedTarget "Ca2+ phosphate nephrolitiasis" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012580 ; owl:annotatedTarget "Ca2+ phosphate urolithiasis" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012581 ; owl:annotatedTarget "An isolated cyst of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012581 ; owl:annotatedTarget "Simple kidney cyst" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012582 ; owl:annotatedTarget "A bilateral form of developmental dysplasia of the kidney." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012583 ; owl:annotatedTarget "One sided hypoplasia of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012583 ; owl:annotatedTarget "Small kidney on one side" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012583 ; owl:annotatedTarget "Underdeveloped kidney on one side" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012584 ; owl:annotatedTarget "Two sided hypoplasia of the kidney." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36237 ; owl:annotatedTarget "Reaxys:13246008" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012585 ; owl:annotatedTarget "Atrophy of the kidney." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012585 ; owl:annotatedTarget "Kidney degeneration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36237 ; owl:annotatedTarget "cholan-24-oic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012586 ; owl:annotatedTarget "A two-sided form of atrophy of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012586 ; owl:annotatedTarget "Bilateral kidney degeneration" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "Beilstein:3214794" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012587 ; owl:annotatedTarget "Hematuria that is visible upon inspection of the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012587 ; owl:annotatedTarget "Bloody urine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012587 ; owl:annotatedTarget "Gross hematuria" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:Eurenomics_ewuehl", "PMID:29910038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012588 ; owl:annotatedTarget "A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012588 ; owl:annotatedTarget "SRNS" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012589 ; owl:annotatedTarget "A form of nephrotic syndrome that does not respond to any immunosuppresive treatment." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "CAS:546-18-9" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012590 ; owl:annotatedTarget "An abnormal amount of urine production." . [] oboInOwl:hasDbXref "PMID:25215103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012591 ; owl:annotatedTarget "An abnormality in the concentration of electrolytes in the urine." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "LIPID_MAPS_instance:LMST04010441" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012592 ; owl:annotatedTarget "Increased concentration of albumin in the urine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012593 ; owl:annotatedTarget "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer", "PMID:30571025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012594 ; owl:annotatedTarget "The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012594 ; owl:annotatedTarget "High urine albumin levels" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "5beta-cholan-24-oic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_eweuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012595 ; owl:annotatedTarget "Mildly increased levels of protein in the urine (150-500 mg per day in adults)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012596 ; owl:annotatedTarget "Moderately increased levels of protein in the urine (500-1000 mg per day in adults)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012597 ; owl:annotatedTarget "Severely increased levels of protein in the urine (1000-3000 mg per day in adults)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012597 ; owl:annotatedTarget "Severly high blood protein levels" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "5beta-cholanic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012598 ; owl:annotatedTarget "An abnormal concentration of potassium(1+) in the urine." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012598 ; owl:annotatedTarget "Abnormal urine K concentration" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Minprostin E2" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "(5beta)-cholan-24-oic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012599 ; owl:annotatedTarget "An abnormal phosphate concentration in the urine." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "5beta-cholanoic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012600 ; owl:annotatedTarget "An abnormal concentration of chloride in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012600 ; owl:annotatedTarget "Abnormal urine Cl concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012600 ; owl:annotatedTarget "Abnormal urine Cl- concentration" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36238 ; owl:annotatedTarget "ursocholanic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012601 ; owl:annotatedTarget "An decreased concentration of chloride in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012601 ; owl:annotatedTarget "Low urine chloride levels" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012602 ; owl:annotatedTarget "High urine chloride in the presence of hypochloridemia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012602 ; owl:annotatedTarget "Kidney chloride wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012602 ; owl:annotatedTarget "Renal Cl wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012602 ; owl:annotatedTarget "Renal Cl- wasting" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012603 ; owl:annotatedTarget "An abnormal concentration of sodium in the urine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012604 ; owl:annotatedTarget "An abnormally decreased sodium concentration in the urine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012604 ; owl:annotatedTarget "Low urine sodium levels" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012605 ; owl:annotatedTarget "An increased concentration of sodium(1+) in the urine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012606 ; owl:annotatedTarget "An abnormally increased sodium concentration in the urine in the presence of hyponatremia." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012606 ; owl:annotatedTarget "Renal Na wasting" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012606 ; owl:annotatedTarget "Renal Na+ wasting" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "Beilstein:3950858" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "PMID:11948155" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012607 ; owl:annotatedTarget "An abnormal concentration of magnesium the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012607 ; owl:annotatedTarget "Abnormal urine magnesium concentration" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PGE2" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "PMID:14593448" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012608 ; owl:annotatedTarget "An increased concentration of magnesium the urine." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "Reaxys:3950858" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012609 ; owl:annotatedTarget "An decreased concentration of magnesium the urine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012609 ; owl:annotatedTarget "Decreased urine magnesium" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012609 ; owl:annotatedTarget "Low urine magnesium levels" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "UM-BBD_compID:c0235" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "3-(4-Hydroxyphenyl)pyruvate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012610 ; owl:annotatedTarget "Abnormal amount of urate in the urine." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "3-(4-hydroxyphenyl)-2-oxopropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012612 ; owl:annotatedTarget "Abnormal concentration of sulfate in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012612 ; owl:annotatedTarget "Abnormal urinary sulphate concentration" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "3-(4-hydroxyphenyl)pyruvate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012613 ; owl:annotatedTarget "Elevated concentration of SO4(2-), i.e., sulfate, in the urine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012613 ; owl:annotatedTarget "Increased urinary sulphate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012614 ; owl:annotatedTarget "An anomalous finding in the examination of the urine for cells." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl", "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012615 ; owl:annotatedTarget "The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine." . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0012615 ; owl:annotatedTarget "Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. The casts are suibsequently eliminated via the urine and may be seen by microscopy of the urine sediment. A large number of casts can indicate kidney disease. Urinary casts are composed of Tamm-Horsfall protein, which is a mucoprotein that is secreted by the distal loop of Henle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "3-(p-hydroxyphenyl)pyruvate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012616 ; owl:annotatedTarget "Presence of leukocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer", "PMID:8856231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012617 ; owl:annotatedTarget "Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012618 ; owl:annotatedTarget "A cyst located along the allantois canal." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "4-Hydroxyphenylpyruvate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012619 ; owl:annotatedTarget "Presence of a many diverticula (sac or pouch) in the wall of the urinary bladder." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012619 ; owl:annotatedTarget "Multiple pouches in bladder wall" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012620 ; owl:annotatedTarget "A developmental anomaly associated with the failure of rectum, vagina, and bladder to separate." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "HPP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012621 ; owl:annotatedTarget "Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_ewuehl" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012622 ; owl:annotatedTarget "Functional anomaly of the kidney persisting for at least three months." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012622 ; owl:annotatedTarget "Chronic kidney disease" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012622 ; owl:annotatedTarget "Renal failure, progressive" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012623 ; owl:annotatedTarget "A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012624 ; owl:annotatedTarget "A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012625 ; owl:annotatedTarget "A type of chronic kidney disease with moderately reduced glomerular filtration rate (GFR 30-59 mL/min/1.73 m2)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:Eurenomics_fschaefer" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012626 ; owl:annotatedTarget "A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012626 ; owl:annotatedTarget "Stage 4 chronic kidney disease" . [] oboInOwl:hasDbXref , "PMID:23157966" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012627 ; owl:annotatedTarget "Deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36242 ; owl:annotatedTarget "p-hydroxyphenylpyruvate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012628 ; owl:annotatedTarget "An anomaly of the suspensory ligament of lens, also known as the ciliary zonule. These ligaments represent a series of fibers connecting the ciliary body and lens of the eye, holding the lens in place." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/zonule_of_zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012628 ; owl:annotatedTarget "Abnormality of zinn's membrane" . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/zonule_of_zinn" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012628 ; owl:annotatedTarget "Zonule of zinn abnormality" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "PGE2" . [] oboInOwl:hasDbXref , "PMID:5472193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012629 ; owl:annotatedTarget "Tremulousness (trembling) of the lens of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012629 ; owl:annotatedTarget "Trembling eye lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012630 ; owl:annotatedTarget "An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012631 ; owl:annotatedTarget "Accumulation of abnormal amounts of pigment within the trabecular meshwork." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012632 ; owl:annotatedTarget "An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye." . [] a owl:Axiom ; rdfs:label "Abnormal intraocular pressure" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0012632 ; owl:annotatedTarget "MP:0005257" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012632 ; owl:annotatedTarget "Abnormal eye pressure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012632 ; owl:annotatedTarget "Abnormal intraocular pressure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012633 ; owl:annotatedTarget "A difference in the amount of intraocular pressure in the right and left eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012634 ; owl:annotatedTarget "Shedding of the pigment granules that normally adhere to the back of the iris into the aqueous humor." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36277 ; owl:annotatedTarget "bile acid salts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012635 ; owl:annotatedTarget "Reduction in the amount of blood flow to the iris." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012636 ; owl:annotatedTarget "Blockage of the retinal vein." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "High urine calcium in the presence of hypocalcemia." . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "Kidney Ca wasting" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "Kidney Ca2+ wasting" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "Kidney calcium wasting" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "Renal Ca wasting" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012637 ; owl:annotatedTarget "Renal Ca2+ wasting" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36299 ; owl:annotatedTarget "tricarboxylic acid monoanions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012638 ; owl:annotatedTarget "A functional anomaly of the nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36300 ; owl:annotatedTarget "tricarboxylic acid dianions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012639 ; owl:annotatedTarget "A structural anomaly of the nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012639 ; owl:annotatedTarget "Abnormal shape of nervous system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012640 ; owl:annotatedTarget "A deviation from the norm of the intracranial pressure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012641 ; owl:annotatedTarget "A reduction of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." . [] oboInOwl:hasDbXref , "PMID:20305277", "PMID:26331051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012642 ; owl:annotatedTarget "Cerebellar agenesis is defined by the near complete absence of cerebellar tissue with only remnants of the anterior vermis, flocculus, and/or middle cerebellar peduncles." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36309 ; owl:annotatedTarget "macrocyclic tetrapyrroles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012643 ; owl:annotatedTarget "Decreased amount of pigmentation in the fovea centralis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36309 ; owl:annotatedTarget "cyclic tetrapyrroles" . [] oboInOwl:hasDbXref , "PMID:23810640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012644 ; owl:annotatedTarget "An elevated concentration of lactate in the caudate nucleus. This finding can be elicited by magnetic resonance spectroscopy imaging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012645 ; owl:annotatedTarget "Increase in size of a peripheral nerve. This finding can be appreciated by palpation along the axis of the nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012645 ; owl:annotatedTarget "Enlarged peripheral nerves" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36309 ; owl:annotatedTarget "macrocyclic tetrapyrrole" . [] oboInOwl:hasDbXref , "PMID:23061004", "PMID:4380054" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012646 ; owl:annotatedTarget "A testis that is located at the upper scrotum or lower inguinal canal and that can be made to descend completely into the scrotum without resistance by manual reduction but returns to its original position by the cremasteric reflex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012647 ; owl:annotatedTarget "Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012647 ; owl:annotatedTarget "Abnormal inflammatory response" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36338 ; owl:annotatedTarget "leptons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012648 ; owl:annotatedTarget "An abnormal reduction in the inflammatory response to injury or infection." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012648 ; owl:annotatedTarget "Decreased inflammatory response" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36339 ; owl:annotatedTarget "baryons" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012649 ; owl:annotatedTarget "A abnormal increase in the inflammatory response to injury or infection." . [] oboInOwl:hasDbXref , , "PMID:15159468", "PMID:20301504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012650 ; owl:annotatedTarget "Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012651 ; owl:annotatedTarget "A severe form of gait ataxia such that an affected person cannot walk at all." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012652 ; owl:annotatedTarget "Asthma attacks following exercise." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36340 ; owl:annotatedTarget "fermion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012652 ; owl:annotatedTarget "Exercise-induced asthma" . [] oboInOwl:hasDbXref , "PMID:22794687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012653 ; owl:annotatedTarget "Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012653 ; owl:annotatedTarget "Acute severe asthma" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prepidil" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36340 ; owl:annotatedTarget "fermions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012654 ; owl:annotatedTarget "Abnormal concentration of dopamine in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36342 ; owl:annotatedTarget "subatomic particles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012655 ; owl:annotatedTarget "Increased concentration of dopamine in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36343 ; owl:annotatedTarget "composite particles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012656 ; owl:annotatedTarget "Decreased concentration of dopamine in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012657 ; owl:annotatedTarget "A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36344 ; owl:annotatedTarget "hadrons" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012657 ; owl:annotatedTarget "Abnormal brain PET scan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012658 ; owl:annotatedTarget "An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012658 ; owl:annotatedTarget "Abnormal brain FDG PET scan" . [] oboInOwl:hasDbXref , "PMID:23585882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012659 ; owl:annotatedTarget "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012660 ; owl:annotatedTarget "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012661 ; owl:annotatedTarget "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan." . [] oboInOwl:hasDbXref , "PMID:15073255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012662 ; owl:annotatedTarget "Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan." . [] oboInOwl:hasDbXref , "PMID:16376782", "PMID:27206819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012663 ; owl:annotatedTarget "A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012664 ; owl:annotatedTarget "A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle." . [] oboInOwl:hasDbXref , "PMID:16376782", "PMID:27206819", "PMID:29083812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012665 ; owl:annotatedTarget "A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle, defined as a left ventricular ejection fraction of 30-39 percent." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36347 ; owl:annotatedTarget "nuclear particle" . [] oboInOwl:hasDbXref , "PMID:16376782", "PMID:27206819", "PMID:29083812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012666 ; owl:annotatedTarget "A large reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at over 50 percent, and a severe reduction is defined as less than 30 percent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012667 ; owl:annotatedTarget "An abnormal motion of a segment of the left ventricle during the cardiac cycle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012669 ; owl:annotatedTarget "An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012670 ; owl:annotatedTarget "Syncope following a quick change in position from lying down to standing." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:16030444" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012671 ; owl:annotatedTarget "Poverty of behavior and speech output, lack of initiative, loss of emotional responses, psychomotor slowing, and prolonged speech latency." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012672 ; owl:annotatedTarget "Akinetic mutism is essentially characterized by a total absence of spontaneous behavior and speech occurring in the presence of preserved visual tracking." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012673 ; owl:annotatedTarget "A failure to develop of the upper vagina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012673 ; owl:annotatedTarget "Absent upper vagina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012674 ; owl:annotatedTarget "A failure to develop of the lower part of the vagina." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012674 ; owl:annotatedTarget "Absent lower vagina" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36357 ; owl:annotatedTarget "polyatomic entities" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012675 ; owl:annotatedTarget "An abnormal build up of iron (Fe) in brain tissue." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012675 ; owl:annotatedTarget "Iron accumulation in brain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36358 ; owl:annotatedTarget "polyatomic ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012676 ; owl:annotatedTarget "An anomalous build up of copper (Cu) in the brain." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012676 ; owl:annotatedTarget "Copper accumulation in brain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012678 ; owl:annotatedTarget "An anomalous build up of iron (Fe) in the substantia nigra." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012679 ; owl:annotatedTarget "An increase in the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36359 ; owl:annotatedTarget "phosphorus oxoacid derivative" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012680 ; owl:annotatedTarget "An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin." . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Propess" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36544 ; owl:annotatedTarget "sialodiosylceramides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012681 ; owl:annotatedTarget "A structural abnormality of the pineal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012682 ; owl:annotatedTarget "Accumulation of calcium salts in the pineal gland." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36586 ; owl:annotatedTarget "carbonyl compounds" . [] oboInOwl:hasDbXref , "PMID:21801982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012683 ; owl:annotatedTarget "A glial uniloculated or multiloculated fluid-filled sac that either reside within or completely replace the pineal gland." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012684 ; owl:annotatedTarget "An abnormal increase or decrease in the quantity of three-dimensional space taken up by the pineal gland." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:24456088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012685 ; owl:annotatedTarget "An abnormal reduction in the quantity of three-dimensional space taken up by the pineal gland." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36587 ; owl:annotatedTarget "oxo compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012686 ; owl:annotatedTarget "An abnormal elevation in the quantity of three-dimensional space taken up by the pineal gland." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36587 ; owl:annotatedTarget "organic oxo compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012687 ; owl:annotatedTarget "Failure to develop of the pineal gland, defined clinically as the absence of the pineal gland with no indication of the pineal gland even having been present." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36606 ; owl:annotatedTarget "acid anhydride" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012688 ; owl:annotatedTarget "A functional abnormality of the pineal gland." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:22724080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012689 ; owl:annotatedTarget "An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012690 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a diffuse hypointensity affecting the entire thalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012691 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hypointensity affecting a particular region of the thalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012692 ; owl:annotatedTarget "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hyperintensity affecting a particular region of the thalamus." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36606 ; owl:annotatedTarget "acid anhydrides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012693 ; owl:annotatedTarget "Deviation from the normal range of size of the thalamus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36606 ; owl:annotatedTarget "acid anhydrides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012694 ; owl:annotatedTarget "An increase in the quantity of space occupied by the thalamus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012695 ; owl:annotatedTarget "A reduction in the quantity of space occupied by the thalamus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012696 ; owl:annotatedTarget "A deviation from normal signal on magnetic resonance imaging (MRI) of the thalamus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36606 ; owl:annotatedTarget "anhydride d'acide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012697 ; owl:annotatedTarget "Decreased size of the basal ganglia." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prostarmon E" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36608 ; owl:annotatedTarget "acyclic acid anhydride" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012698 ; owl:annotatedTarget "Focal proliferation of glial cells in the cerebellum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36608 ; owl:annotatedTarget "acyclic acid anhydrides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36608 ; owl:annotatedTarget "acyclic acid anhydrides" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012699 ; owl:annotatedTarget "A structural abnormality of a diaphysis of the leg." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012699 ; owl:annotatedTarget "Anomaly of shaft of long bone of lower limb" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36608 ; owl:annotatedTarget "acyclic anhydrides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012700 ; owl:annotatedTarget "A functional anomaly of the large intestine." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012701 ; owl:annotatedTarget "A sudden, irresistible need to have a bowel movement." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012701 ; owl:annotatedTarget "Faecal urgency" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012702 ; owl:annotatedTarget "A repeated, painful urge to defecate without excreting stool." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36699 ; owl:annotatedTarget "adrenal cortex hormones" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012703 ; owl:annotatedTarget "Abnormality in the space in the meninges beneath the arachnoid membrane and above the pia mater that contains the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012704 ; owl:annotatedTarget "An increase in size of the anatomic space between the arachnoid membrane and pia mater." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36699 ; owl:annotatedTarget "corticosteroid hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012704 ; owl:annotatedTarget "Widened subarachnoid spaces" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012705 ; owl:annotatedTarget "An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012706 ; owl:annotatedTarget "An increase in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012707 ; owl:annotatedTarget "An increase in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012708 ; owl:annotatedTarget "A decrease in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012709 ; owl:annotatedTarget "A deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012710 ; owl:annotatedTarget "Excessive growth of a nail laterally into the nail fold." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012710 ; owl:annotatedTarget "Ingrown nail" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012711 ; owl:annotatedTarget "A delay in the process of formation and maturation of the epiphysis of one or more vertebrae." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012711 ; owl:annotatedTarget "Delayed maturation of the end part of the vertebral bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012712 ; owl:annotatedTarget "The presence of a mild form of hearing impairment." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012712 ; owl:annotatedTarget "Mild hearing impairment" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012713 ; owl:annotatedTarget "The presence of a moderate form of hearing impairment." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012713 ; owl:annotatedTarget "Moderate hearing impairment" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012714 ; owl:annotatedTarget "A severe form of hearing impairment." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012714 ; owl:annotatedTarget "Severe deafness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012714 ; owl:annotatedTarget "Severe hearing impairment" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012714 ; owl:annotatedTarget "Severe hearing loss" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012715 ; owl:annotatedTarget "A profound (essentially complete) form of hearing impairment." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012715 ; owl:annotatedTarget "Profound hearing impairment" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36711 ; owl:annotatedTarget "phosphoethanolamines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012716 ; owl:annotatedTarget "The presence of a moderate form of conductive hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012717 ; owl:annotatedTarget "A severe form of conductive hearing impairment." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012718 ; owl:annotatedTarget "Abnormal structure of the gastrointestinal tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36818 ; owl:annotatedTarget "seco-cholestanes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012718 ; owl:annotatedTarget "Abnormal shape of the digestive system" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012718 ; owl:annotatedTarget "Morphological abnormality of the GI tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012719 ; owl:annotatedTarget "Abnormal functionality of the gastrointestinal tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36830 ; owl:annotatedTarget "monoanions" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012719 ; owl:annotatedTarget "Functional abnormality of the GI tract" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012719 ; owl:annotatedTarget "GI dysfunction" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Tumor (An abnormal mass of tissue resulting from abnormally dividing cells) of the nasal cavity." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Nasal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Nasal tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Nose cancer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Tumor of the nose" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012720 ; owl:annotatedTarget "Tumour of the nose" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prostenone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36834 ; owl:annotatedTarget "3-hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012721 ; owl:annotatedTarget "A vascular malformation resulting from a developmental error of venous tissue composed of dysmorphic channels lined by flattened endothelium and exhibiting slow turnover. A venous malformation may present as a blue patch on the skin ranging to a soft blue mass. Venous malformations are easily compressible and usually swell in thewhen venous pressure increases (e.g., when held in a dependent position or when a child cries). They may be relatively localized or quite extensive within an anatomic region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012721 ; owl:annotatedTarget "Venous malformations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012722 ; owl:annotatedTarget "Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012723 ; owl:annotatedTarget "Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36836 ; owl:annotatedTarget "PMID:10535978" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Edema in the region of the upper eyelid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Cellulitis of upper eyelid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Fullness of upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Puffiness of upper eyelid" . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36836 ; owl:annotatedTarget "PMID:12829805" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Swelling of upper eyelid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012724 ; owl:annotatedTarget "Upper eyelid oedema" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012725 ; owl:annotatedTarget "A soft tissue continuity in the A/P axis between two digits that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two digits that lies significantly distal to the flexion crease that overlies the metacarpophalangeal or metatarsophalangeal joint of the adjacent digits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012726 ; owl:annotatedTarget "An abnormally decreased potassium concentration in the blood occurring periodically with a return to normal between the episodes." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012726 ; owl:annotatedTarget "Recurrent low potassium" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36836 ; owl:annotatedTarget "3beta-hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012727 ; owl:annotatedTarget "An abnormal localized widening (dilatation) of the thoracic aorta." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36836 ; owl:annotatedTarget "a 3beta-hydroxysteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012728 ; owl:annotatedTarget "A concentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves the full circumference of the vessel wall" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36838 ; owl:annotatedTarget "17-hydroxy steroids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36841 ; owl:annotatedTarget "11-hydroxy steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012729 ; owl:annotatedTarget "An eccentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves only a portion of the circumference of the vessel wall" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012730 ; owl:annotatedTarget "Absence of the tongue owing to a developmental abnormality." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012730 ; owl:annotatedTarget "Missing tongue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012730 ; owl:annotatedTarget "Failure of development of tongue" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36853 ; owl:annotatedTarget "hydroxy seco-steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012731 ; owl:annotatedTarget "Abnormal anatomic location of the anterior pituitary gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012732 ; owl:annotatedTarget "An abnormality of the anus or rectum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012733 ; owl:annotatedTarget "A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin." . [] oboInOwl:hasDbXref , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012733 ; owl:annotatedTarget "Flat, discolored area of skin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012733 ; owl:annotatedTarget "Flat, discoloured area of skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012734 ; owl:annotatedTarget "Low blood glucose is accompanied by elevated levels of ketone bodies in the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012734 ; owl:annotatedTarget "Ketotic low blood sugar" . [] oboInOwl:hasDbXref , "PMID:16428719", "PMID:17540788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012735 ; owl:annotatedTarget "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012735 ; owl:annotatedTarget "Cough" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36885 ; owl:annotatedTarget "20-oxo steroids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012735 ; owl:annotatedTarget "Coughing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012736 ; owl:annotatedTarget "A profound delay in the achievement of motor or mental milestones in the domains of development of a child." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012736 ; owl:annotatedTarget "Psychomotor retardation, profound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012737 ; owl:annotatedTarget "A discrete abnormal tissue mass that protrudes into the lumen of the small intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36887 ; owl:annotatedTarget "18-oxo steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Agenesis of canine tooth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Absent canines" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Failure of development of canine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Failure of development of eye tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Absence of canine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Absence of eye tooth" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Missing canine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012738 ; owl:annotatedTarget "Missing eye tooth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012739 ; owl:annotatedTarget "Failure to develop of the small intestine." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prostin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36902 ; owl:annotatedTarget "chalcogen hydride" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012739 ; owl:annotatedTarget "Undeveloped small intestine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012740 ; owl:annotatedTarget "A tumor of the skin or mucous membrane with finger-like projections." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012741 ; owl:annotatedTarget "Absence of a testis from the scrotum on one side owing to failure of the testis or testes to descend through the inguinal canal to the scrotum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36902 ; owl:annotatedTarget "chalcogen hydrides" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012742 ; owl:annotatedTarget "Fingernail that appears thin when viewed on end." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012742 ; owl:annotatedTarget "Thin fingernail" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36914 ; owl:annotatedTarget "inorganic ions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012743 ; owl:annotatedTarget "Excessive fat around the stomach and abdomen." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012743 ; owl:annotatedTarget "Abdominal obesity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36915 ; owl:annotatedTarget "inorganic cations" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012743 ; owl:annotatedTarget "Central obesity" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012744 ; owl:annotatedTarget "Failure of the femur to develop." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012744 ; owl:annotatedTarget "Absent thighbone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "Cation" . [] oboInOwl:hasDbXref "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012745 ; owl:annotatedTarget "Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012745 ; owl:annotatedTarget "Decreased height of palpebral fissure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012745 ; owl:annotatedTarget "Short opening between the eyelids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "cation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012745 ; owl:annotatedTarget "Short palpebral fissures" . [] oboInOwl:hasDbXref , "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012746 ; owl:annotatedTarget "Toenail that appears thin when viewed on end." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012746 ; owl:annotatedTarget "Thin toenail" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "cation" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012746 ; owl:annotatedTarget "Thin toenails" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012747 ; owl:annotatedTarget "A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012748 ; owl:annotatedTarget "A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012749 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hypointensity affecting a particular region of the brainstem." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012750 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a diffuse hypointensity affecting the entire brainstem." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012751 ; owl:annotatedTarget "A deviation from normal signal on magnetic resonance imaging (MRI) of the basal ganglia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012752 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hypointensity affecting a particular region of the basal ganglia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012753 ; owl:annotatedTarget "A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a diffuse hypointensity affecting all of the basal ganglia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "Kation" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012754 ; owl:annotatedTarget "Increased amount of myelin in the central nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "Kationen" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012755 ; owl:annotatedTarget "Abnormal increase in size of the brainstem." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012756 ; owl:annotatedTarget "An increased polymorphonuclear cell count in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming", "PMID:28723006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012757 ; owl:annotatedTarget "A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "cationes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012757 ; owl:annotatedTarget "Abnormal neuron shape" . [] oboInOwl:hasDbXref , "PMID:31783983" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012758 ; owl:annotatedTarget "Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012758 ; owl:annotatedTarget "NDD" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:KI_phemming" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012759 ; owl:annotatedTarget "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012760 ; owl:annotatedTarget "Impaired social reciprocity" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:BRAND_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "Prostin E2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36916 ; owl:annotatedTarget "cations" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012761 ; owl:annotatedTarget "A developmental anomaly in which the mastoid process fails to form and is thus found to be congenitally absent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012761 ; owl:annotatedTarget "Failure of development of mastoid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012761 ; owl:annotatedTarget "Mastoid agenesis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36961 ; owl:annotatedTarget "chalcocarbonic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012762 ; owl:annotatedTarget "The presence of atrophy (wasting) of the cerebral white matter." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012763 ; owl:annotatedTarget "A sudden attack of dyspnea that occurs while the affected person is at rest." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012763 ; owl:annotatedTarget "Paroxysmal dyspnoea" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012764 ; owl:annotatedTarget "A sensation of breathlessness in the recumbent position, relieved by sitting or standing." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012765 ; owl:annotatedTarget "An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebellum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012766 ; owl:annotatedTarget "An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebrum." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36961 ; owl:annotatedTarget "chalcocarbonic acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012767 ; owl:annotatedTarget "A deviation from normal size of the placenta." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012768 ; owl:annotatedTarget "Respiratory failure in the newborn." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012769 ; owl:annotatedTarget "A deviation from normal of the length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012769 ; owl:annotatedTarget "Abnormal arm span" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012770 ; owl:annotatedTarget "Decreased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36961 ; owl:annotatedTarget "chalcocarbonic acids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012770 ; owl:annotatedTarget "Reduced arm span" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012771 ; owl:annotatedTarget "Increased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012771 ; owl:annotatedTarget "Increased arm span" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012772 ; owl:annotatedTarget "A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012773 ; owl:annotatedTarget "Decreased ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis. Consider the term Disproportionate tall stature (HP:0001519) if tall stature is also present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012774 ; owl:annotatedTarget "Elevated ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:CINEAS_asollie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012775 ; owl:annotatedTarget "A lacy pattern or iris pigmentation that resembles the spokes of a bicycle wheel." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36962 ; owl:annotatedTarget "organochalcogen compound" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:CINEAS_asollie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012776 ; owl:annotatedTarget "A structural anomaly of the ciliary body." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:CINEAS_asollie" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012777 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the retina." . [] oboInOwl:hasDbXref "PMID:20435268", "PMID:23436975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012778 ; owl:annotatedTarget "A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte." . [] oboInOwl:hasDbXref "PMID:21776317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012779 ; owl:annotatedTarget "Hearing loss that occurs acutely and resolves completely." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012780 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012780 ; owl:annotatedTarget "Ear tumor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36962 ; owl:annotatedTarget "organochalcogen compounds" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012780 ; owl:annotatedTarget "Ear tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012781 ; owl:annotatedTarget "A type of hearing impairment affecting primarily the middle frequencies of sound (1000 Hz to 3000 Hz)." . [] oboInOwl:hasDbXref , "PMID:20301471" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012782 ; owl:annotatedTarget "A type of nephrogenic rest associated with multiple lesions in the periphery of the renal lobe." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012782 ; owl:annotatedTarget "Perilobar nephrogenic rests" . [] oboInOwl:hasDbXref , "PMID:20301471" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012783 ; owl:annotatedTarget "A type of nephrogenic rest usually representing single lesions within the renal lobe, renal sinus, or calyceal walls." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012783 ; owl:annotatedTarget "Intralobar nephrogenic rests" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012784 ; owl:annotatedTarget "Inflammation of the connective and adipose tissues surrounding the kidney." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_36963 ; owl:annotatedTarget "PMID:17586126" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012785 ; owl:annotatedTarget "Chronic loss of joint motion in a finger due to structural changes in non-bony tissue." . [] oboInOwl:hasDbXref , "PMID:20639019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012786 ; owl:annotatedTarget "Repeated infections of the urinary bladder." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_36963 ; owl:annotatedTarget "organooxygen compound" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012786 ; owl:annotatedTarget "Recurrent bladder infections" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012787 ; owl:annotatedTarget "Repeated episodes of pyelonephritis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012788 ; owl:annotatedTarget "A net-like pattern of increased pigmentation of the oral cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012788 ; owl:annotatedTarget "Mottled pigmentation of oral mucosa" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012788 ; owl:annotatedTarget "Reticulate pigmentation of oral mucous membrane" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_36963 ; owl:annotatedTarget "organooxygen compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012789 ; owl:annotatedTarget "Underdevelopment of the heel bone." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012789 ; owl:annotatedTarget "Small heel bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012789 ; owl:annotatedTarget "Underdeveloped heel bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012790 ; owl:annotatedTarget "An anomaly in the process of intramembranous ossification by which flat bones (cranial bones of the skull, i.e., the frontal, parietal, occipital, and temporal bones, and the clavicles) are formed." . (obo:GO_0001503 [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:UBERON_0000976 ] ) . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012791 ; owl:annotatedTarget "An anomaly of the process of formation of bone in the humerus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012791 ; owl:annotatedTarget "Abnormal maturation of long bone in upper arm" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "U 12062" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37022 ; owl:annotatedTarget "amino-acid anion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37022 ; owl:annotatedTarget "amino acid anions" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0012792 ; owl:annotatedTarget _:genid86692 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012792 ; owl:annotatedTarget "A lack of bone mineralization of one or more body of thoracic vertebra." . [] oboInOwl:hasDbXref , "PMID:16301726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012793 ; owl:annotatedTarget "A kinked appearance of the brainstem, i.e., an exaggerated flexure." . [] oboInOwl:hasDbXref , "PMID:16239634" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012794 ; owl:annotatedTarget "Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37022 ; owl:annotatedTarget "amino-acid anions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012795 ; owl:annotatedTarget "A morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination." . [] oboInOwl:hasDbXref , "PMID:23557744" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012796 ; owl:annotatedTarget "An elevation in the ratio of the diameter of the cup of the optic disc to the total diameter of the disc. The optic disc has an orange-pink rim with a pale centre (the cup) that does not contain neuroretinal tissue. An increase in this ratio therefore may indicate a decrease in the quantity of healthy neuroretinal cells." . [] oboInOwl:hasDbXref "NCIT:C3723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012797 ; owl:annotatedTarget "A benign or malignant neoplasm arising from the lymphatic vessels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012797 ; owl:annotatedTarget "Lymphatic vessel tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012797 ; owl:annotatedTarget "Lymphatic vessel tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012798 ; owl:annotatedTarget "Infiltration of smooth muscle-like cells in lymph vessels as well as the lung (pleura, alveolar septa, bronchi, pulmonary vessels and lymphatics as well as lymph nodes, especially in posterior mediastinum and retroperitoneum). Focal emphysema can develop because of airway narrowing, and the thoracic duct may be obliterated. Pulmonary lymphangiomyomatosis may lead to multiple small cysts with a hamartomatous proliferation of smooth muscle in their walls." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "One-sided weakness of the muscles of facial expression and eye closure." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Facial droop" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Paralysis of one side of the face" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Unilateral facial muscle paralysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Unilateral facial muscle weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Unilateral facial paralysis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Unilateral facial weakness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012799 ; owl:annotatedTarget "Weakness of one side of the face" . [] oboInOwl:hasDbXref , "PMID:20496093" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "A cranial suture that is in addition to canonical membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "Extra cranial suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "Supernumary cranial suture" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "Accessory fontanelle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "Extra fontanelle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012800 ; owl:annotatedTarget "Supernumary fontanelle" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Bigonial distance (lower facial width) more than 2 standard deviations below the mean (objective); or an apparently decreased width of the lower jaw (mandible) when viewed from the front (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Narrow jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Narrow lower face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Narrow lower jaw" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Thin lower face" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012801 ; owl:annotatedTarget "Thin lower jaw" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "Beilstein:1724349" . [] oboInOwl:hasDbXref , "PMID:19125436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012802 ; owl:annotatedTarget "Bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012802 ; owl:annotatedTarget "Broad jaw" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012802 ; owl:annotatedTarget "Broad lower face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012802 ; owl:annotatedTarget "Wide jaw" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012803 ; owl:annotatedTarget "Inequality of refractive power of the two eyes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012804 ; owl:annotatedTarget "Disruption of the epithelial layer of the cornea with involvement of the underlying stroma." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "Beilstein:1773077" . [] oboInOwl:hasDbXref , "PMID:19920562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012805 ; owl:annotatedTarget "Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris." . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012806 ; owl:annotatedTarget "A fleshy, tube-like structure usually located in the midline of the face or just to one side of the midline." . [] oboInOwl:hasDbXref "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012807 ; owl:annotatedTarget "Insertion of the posterior columella superior to the nasal base." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012807 ; owl:annotatedTarget "Ala lower than columella" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "An anomaly of the nasal base, which can be conceived of as an imaginary line between the most lateral points of the external inferior attachments of the alae nasi to the face." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Abnormal nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Abnormality of base of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Anomaly of base of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Anomaly of nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Deformity of base of nose" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "CAS:542-32-5" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Deformity of nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Malformation of base of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012808 ; owl:annotatedTarget "Malformation of nasal base" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Decreased distance between the attachments of the alae nasi to the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Decreased width of base of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Decreased width of nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Narrow base of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Narrow nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Thin base of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012809 ; owl:annotatedTarget "Thin nasal base" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "PMID:22264337" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Increased distance between the attachments of the alae nasi to the face." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Broad base of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Broad nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Increased width of base of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Increased width of nasal base" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Wide base of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012810 ; owl:annotatedTarget "Wide nasal base" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Increased width of the nasal ridge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Broad dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Broad nasal dorsum" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "U-12,062" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "PMID:31148" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Increased width of dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Increased width of nasal dorsum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Increased width of nasal ridge" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Wide dorsum of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Wide nasal dorsum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Wide nasal ridge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012811 ; owl:annotatedTarget "Broad nasal ridge" . [] oboInOwl:hasDbXref , "PMID:19152422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Increased bulk of tissue alongside the nose. The fullness can be caused by both bony and soft tissues." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Fullness of tissue around the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Thick paranasal tissue" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "PMID:6462455" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Thick tissue around the nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Hyperplasia of paranasal tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0012812 ; owl:annotatedTarget "Hypertrophy of paranasal tissue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012813 ; owl:annotatedTarget "Underdevelopment of the breast on one side only." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012813 ; owl:annotatedTarget "One underdeveloped breast" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "Reaxys:1724349" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012814 ; owl:annotatedTarget "Underdevelopment of the breast on both sides." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012814 ; owl:annotatedTarget "Two underdeveloped breasts" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "2-aminoadipic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012815 ; owl:annotatedTarget "Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012815 ; owl:annotatedTarget "Underdeveloped female external genitalia" . [] oboInOwl:hasDbXref , "PMID:23921774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012816 ; owl:annotatedTarget "A predominantly right ventricular variant of isolated noncompaction cardiomyopathy." . [] oboInOwl:hasDbXref , "PMID:15210614", "PMID:24282766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012817 ; owl:annotatedTarget "A type of cardiomyopathy characterized anatomically by deep trabeculations in the ventricular wall, which define recesses communicating with the main ventricular chamber." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012818 ; owl:annotatedTarget "Noncompaction cardiomyopathy that affects both ventricles." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "2-aminohexanedioic acid" . [] oboInOwl:hasDbXref , "PMID:21304213", "PMID:22185868", "PMID:22361396" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012819 ; owl:annotatedTarget "Inflammation of the myocardium." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "(+/-)-2-Aminoadipic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012819 ; owl:annotatedTarget "Inflammation of heart muscle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "Aad" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012820 ; owl:annotatedTarget "A loss of the ability to move the vocal fold on both sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012821 ; owl:annotatedTarget "Decreased strength of the vocal fold on one side." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012822 ; owl:annotatedTarget "Decreased strength of the vocal fold on both sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012823 ; owl:annotatedTarget "This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012824 ; owl:annotatedTarget "The intensity or degree of a manifestation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012825 ; owl:annotatedTarget "Having a relatively minor degree of severity. For quantitative traits, a deviation of between two and three standard deviations from the appropriate population mean." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012825 ; owl:annotatedTarget "Mild" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012826 ; owl:annotatedTarget "Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012827 ; owl:annotatedTarget "Having a minor degree of severity that is considered to be on the boundary between the normal and the abnormal ranges. For quantitative traits, a deviation of that is less than two standard deviations from the appropriate population mean." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012827 ; owl:annotatedTarget "Borderline" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "DL-2-Aminoadipic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012828 ; owl:annotatedTarget "Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012828 ; owl:annotatedTarget "Severe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012829 ; owl:annotatedTarget "Having an extremely high degree of severity. For quantitative traits, a deviation of more than five standard deviations from the appropriate population mean." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012829 ; owl:annotatedTarget "Profound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012830 ; owl:annotatedTarget "The anatomical localization of the specified phenotypic abnormality." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012831 ; owl:annotatedTarget "The localization with respect to the side of the body of the specified phenotypic abnormality." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012832 ; owl:annotatedTarget "Being present on both sides of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012833 ; owl:annotatedTarget "Being present on only the left or only the right side of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012834 ; owl:annotatedTarget "Being located on the right side of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012835 ; owl:annotatedTarget "Being located on the left side of the body." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "DL-2-Aminohexanedioic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012836 ; owl:annotatedTarget "The pattern by which a phenotype affects one or more regions of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012837 ; owl:annotatedTarget "Affecting all regions without specificity of distribution." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012837 ; owl:annotatedTarget "Generalised" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012838 ; owl:annotatedTarget "Being confined or restricted to a particular location." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012838 ; owl:annotatedTarget "Localised" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012838 ; owl:annotatedTarget "Localized" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012839 ; owl:annotatedTarget "Localized away from the central point of the body." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012839 ; owl:annotatedTarget "Outermost" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012840 ; owl:annotatedTarget "Localized close to the central point of the body." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012841 ; owl:annotatedTarget "The presence of an increased number of twists and turns of the retinal blood vessels." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "DL-alpha-Aminoadipic acid" . [] oboInOwl:hasDbXref "NCIT:C4463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012842 ; owl:annotatedTarget "A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012842 ; owl:annotatedTarget "Skin adnexal tumour" . [] oboInOwl:hasDbXref , "NCIT:C7367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012843 ; owl:annotatedTarget "An uncontrolled autonomous cell-proliferation originating in a hair follicle, which is an epidermal adnexal structures responsible for hair growth." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012844 ; owl:annotatedTarget "A benign tumor originating from the outer root sheath of the hair follicle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012845 ; owl:annotatedTarget "Presence of a unitary trichilemmoma, a benign tumor originating from the outer root sheath of the hair follicle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012846 ; owl:annotatedTarget "Presence of multiple trichilemmomata, a benign tumor originating from the outer root sheath of the hair follicle." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012847 ; owl:annotatedTarget "Epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012848 ; owl:annotatedTarget "The narrowing or partial blockage of a portion of the small intestine." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012848 ; owl:annotatedTarget "Narrowing of small intestine" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "U-12062" . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "alpha-Aminoadipic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "alpha-aminoadipic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012849 ; owl:annotatedTarget "Bleeding from the small intestine." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012849 ; owl:annotatedTarget "Small intestinal bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012849 ; owl:annotatedTarget "Small intestinal haemorrhage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37024 ; owl:annotatedTarget "aminoadipic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012850 ; owl:annotatedTarget "Abnormal small intestinal contractions, such as spasms and intestinal paralysis related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012851 ; owl:annotatedTarget "A narrowing of a segment of colon whereby bowel continuity is maintained." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012851 ; owl:annotatedTarget "Narrowing of the colon" . [] oboInOwl:hasDbXref , "PMID:14568255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012852 ; owl:annotatedTarget "Hepatic fibrosis that reaches from a portal area to another portal area." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012853 ; owl:annotatedTarget "Hypospadias with location of the urethral meatus in the scrotum." . [] oboInOwl:hasDbXref , "PMID:12371222" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012854 ; owl:annotatedTarget "Hypospadias with location of the urethral meatus in the middle of the inferior shaft of the penis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012855 ; owl:annotatedTarget "Increased pigmentation (skin color) of the scrotum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012855 ; owl:annotatedTarget "Increased pigmentation in scrotum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012856 ; owl:annotatedTarget "Anomaly of the folded ridges (wrinkles) of skin of the scrotum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012857 ; owl:annotatedTarget "Increased number or density of the folded ridges (wrinkles) of skin of the scrotum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012858 ; owl:annotatedTarget "Decreased number or density of the folded ridges (wrinkles) of skin of the scrotum." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:23765246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012859 ; owl:annotatedTarget "A white patch or plaque occurring on the surface of the esophageal mucous membranes that cannot be rubbed off and cannot be characterized clinically as any other disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012860 ; owl:annotatedTarget "Formation of excess connective tissue in the testicle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012861 ; owl:annotatedTarget "A gonad that contains both ovarian follicles and testicular tubular elements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012862 ; owl:annotatedTarget "Any structural anomaly of a reproductive cell." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012862 ; owl:annotatedTarget "Abnormally shaped reproductive cell" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012863 ; owl:annotatedTarget "A structural anomaly of a male reproductive cell." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012864 ; owl:annotatedTarget "A structural anomaly of sperm." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012864 ; owl:annotatedTarget "Abnormal shape of sperm" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "Beilstein:4127635" . [] oboInOwl:hasDbXref , "PMID:22198630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012865 ; owl:annotatedTarget "A structural abnormality of the sperm head." . [] oboInOwl:hasDbXref , "PMID:22198630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012866 ; owl:annotatedTarget "A structural abnormality of the sperm neck." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012867 ; owl:annotatedTarget "A structural abnormality of the sperm mid-piece." . [] oboInOwl:hasDbXref , "PMID:22198630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012868 ; owl:annotatedTarget "A structural abnormality of the sperm tail." . [] oboInOwl:hasDbXref , "PMID:10402395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012869 ; owl:annotatedTarget "Spermatozoa with very small cranial ends devoid of any nuclear material, that is, lacking a typical sperm head." . [] oboInOwl:hasDbXref , "PMID:22985611" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012870 ; owl:annotatedTarget "A condition which is considered to be due to the subsequent atrophy and disappearance in fetal life of an initially normal testis. In the presence of spermatic cord structures is evidence of the presence of the testis in early intrauterine life. When associated with a blind-ending spermatic cord, this entity is named as his absence of a testis in an otherwise normal 46XY male is usually unilateral and is assumed to be a consequence of intrauterine or perinatal torsion or infarction." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012870 ; owl:annotatedTarget "Vanishing testis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012871 ; owl:annotatedTarget "A varicocele is a widening of the veins along the spermatic cord, leading to enlarged, twisted veins in the scrotum, and manifested clinically by a painless testicle lump, scrotal swelling, or bulge in the scrotum." . [] oboInOwl:hasDbXref , "MP:0002769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012872 ; owl:annotatedTarget "A structural anomaly of the secretory duct of the testicle that carries spermatozoa from the epididymis to the prostatic urethra where it terminates to form ejaculatory duct." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012873 ; owl:annotatedTarget "Aplasia (congenital absence) of the vas deferens." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "Reaxys:4127635" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012873 ; owl:annotatedTarget "Absent deferent duct" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012873 ; owl:annotatedTarget "Absent ductus deferens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012874 ; owl:annotatedTarget "An abnormal functionality of the male genital system." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "3-hydroxybutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012875 ; owl:annotatedTarget "Abnormality in the process of ejection of semen (usually carrying sperm) from the male reproductive tract." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "3-OH butyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012876 ; owl:annotatedTarget "The emission of semen and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012876 ; owl:annotatedTarget "Premature ejaculation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012877 ; owl:annotatedTarget "The emission of semen and seminal fluid into the bladder instead of through the penis during orgasm." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "dinoprostona" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "3-OH-butyrate" . [] oboInOwl:hasDbXref , "PMID:24528812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012878 ; owl:annotatedTarget "Difficulty of a male in achieving orgasm." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012878 ; owl:annotatedTarget "Delayed ejaculation" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "3-hydroxybutanoate" . [] oboInOwl:hasDbXref , "PMID:24528812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012879 ; owl:annotatedTarget "Inability to ejaculate." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "DL-3-hydroxybutyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012880 ; owl:annotatedTarget "An anomaly of the labia minora, the folds of skin between the outer labia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012880 ; owl:annotatedTarget "Abnormality of the inner vaginal lips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "beta-hydroxy-n-butyrate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012881 ; owl:annotatedTarget "An anomaly of the outer labia." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012881 ; owl:annotatedTarget "Abnormality of vaginal lips" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37054 ; owl:annotatedTarget "beta-hydroxybutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012882 ; owl:annotatedTarget "Overgrowth of the outer labia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012883 ; owl:annotatedTarget "A fluid filled sac located in the Fallopian tube." . [] oboInOwl:hasDbXref , "PMID:24251052" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012884 ; owl:annotatedTarget "A twisting of the Fallopian tube. Sudden onset with sharp, colicky pelvic pain associated with nausea, vomiting, bowel, and bladder symptoms is the usual presentation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012884 ; owl:annotatedTarget "Twisted fallopian tube" . [] oboInOwl:hasDbXref , "PMID:23532389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012885 ; owl:annotatedTarget "The presence of a supernumerary Fallopian tube." . [] oboInOwl:hasDbXref , "PMID:12928726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012886 ; owl:annotatedTarget "An abdominal mass formed by bleeding into a follicular ovarian cyst or corpus luteum cyst." . [] oboInOwl:hasDbXref , "PMID:23766763" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012887 ; owl:annotatedTarget "A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37142 ; owl:annotatedTarget "organoiodine compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012888 ; owl:annotatedTarget "An anomaly of the neck of the uterus (lower part of the uterus), called the uterine cervix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012889 ; owl:annotatedTarget "Abnormal growth of endometrial cells (which are normally limited to the uterus) within the cervix." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37142 ; owl:annotatedTarget "organoiodine compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012890 ; owl:annotatedTarget "Posterior malposition of the anus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012891 ; owl:annotatedTarget "Hair on the neck extends less inferiorly than usual." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012891 ; owl:annotatedTarget "High hairline at back of head" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37163 ; owl:annotatedTarget "CAS:9037-91-6" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012892 ; owl:annotatedTarget "Hypertrophy of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012892 ; owl:annotatedTarget "Increased size of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012892 ; owl:annotatedTarget "Large facial muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012892 ; owl:annotatedTarget "Hyperplasia of facial muscles" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37163 ; owl:annotatedTarget "Glucan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Muscle hypertrophy affecting the muscles of the neck." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Increased size of neck muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Hypertrophy of cervical muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Large neck muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Overgrowth of neck muscles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012893 ; owl:annotatedTarget "Hyperplasia of neck muscles" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37163 ; owl:annotatedTarget "glucan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012894 ; owl:annotatedTarget "Muscle hypertrophy affecting the paraspinal muscles." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012895 ; owl:annotatedTarget "Muscle hypertrophy affecting the scapular muscles." . [] oboInOwl:hasDbXref , "PMID:10402095" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012896 ; owl:annotatedTarget "An anomaly identified by motor evoked potentials (MEPs). MEPs are measured following single-pulse or repetitive transcranial magnetic stimulation and can be used for the assessment of the excitability of the motor cortex and the integrity of conduction along the central and peripheral motor pathways." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "dinoprostone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37163 ; owl:annotatedTarget "glucans" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012897 ; owl:annotatedTarget "An anomaly identified by motor evoked potentials (MEPs) in the arm." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012898 ; owl:annotatedTarget "An anomaly identified by motor evoked potentials (MEPs) in the leg." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:22987687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012899 ; owl:annotatedTarget "Difficulty releasing one's grip associated with prolonged first handgrip relaxation times." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012900 ; owl:annotatedTarget "Slowed relaxation of muscles in the face." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012901 ; owl:annotatedTarget "Slowed relaxation of muscles in the jaw." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012902 ; owl:annotatedTarget "Slowed relaxation of muscles in the leg." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012903 ; owl:annotatedTarget "Slowed relaxation of muscles in the arm." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:14617673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012904 ; owl:annotatedTarget "An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation that is induced by exposure to cold." . [] oboInOwl:hasDbXref , "PMID:15249382", "PMID:15530943", "PMID:24719364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0012905 ; owl:annotatedTarget "Euryblepharon is a congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension, with associated lateral canthal malpositioning and lateral ectropion abnormally wide lid opening." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0012905 ; owl:annotatedTarget "Kabuki syndrome eyelids" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37164 ; owl:annotatedTarget "homopolysaccharide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020034 ; owl:annotatedTarget "A spatial pattern that is spread out, i.e., not localized." . [] oboInOwl:hasDbXref , "PMID:25573808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020035 ; owl:annotatedTarget "A lack of coordination of leg movement manifested by undershoot or overshoot of the intended position of the leg." . [] oboInOwl:hasDbXref , "PMID:20301629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020036 ; owl:annotatedTarget "A lack of coordination of arm movement manifested by undershoot or overshoot of the intended position of the arm." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37164 ; owl:annotatedTarget "homoglycan" . [] oboInOwl:hasDbXref , "PMID:27821973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020037 ; owl:annotatedTarget "A postural abnormality characterized by the inability to stand without external support despite having sufficient muscle strength." . [] oboInOwl:hasDbXref "PMID:24765483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020038 ; owl:annotatedTarget "Elongation, dilatation, and/or tortuosity of the vertebrobasilar segment. The definition of VBD includes: (i) diameter of basilar or vertebral artery over 4.5 mm; or (ii) deviation of any portion more than 10 mm from the shortest expected course; and (iii) length of basilar artery over 29.5 mm or length of intracranial vertebral artery over 23.5 mm." . [] oboInOwl:hasDbXref , "PMID:23479532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020041 ; owl:annotatedTarget "A type of incomitant strabismus in which both elevator muscles (i.e., the inferior oblique and superior rectus muscles) of the same eye are weak leading to restricted elevation and hypotropia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020042 ; owl:annotatedTarget "An ocular movement abnormality characterised by simultaneous weakness of the inferior rectus muscle and superior oblique muscle of the same eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020043 ; owl:annotatedTarget "A type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts upwards and/or downwards." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020045 ; owl:annotatedTarget "A manifest or latent ocular deviation in which one or both eyes tends to deviate nasally." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020046 ; owl:annotatedTarget "A form of esotropia (convergent deviation of the eyes) associated with activation of the accommodative reflex." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37164 ; owl:annotatedTarget "homopolysaccharides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020049 ; owl:annotatedTarget "A manifest or latent ocular deviation in which one or both eyes tends to deviate temporally." . [] oboInOwl:hasDbXref "PMID:23509356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020050 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against granulocyte-macrophage colony stimulating factor." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020050 ; owl:annotatedTarget "Anti-GM-CSF antibody positivity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37175 ; owl:annotatedTarget "organic hydrides" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020058 ; owl:annotatedTarget "Abnormal RBC count" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020059 ; owl:annotatedTarget "Increased RBC count" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020060 ; owl:annotatedTarget "Decreased RBC count" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020061 ; owl:annotatedTarget "Abnormal Hb concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020061 ; owl:annotatedTarget "Abnormal haemoglobin concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020062 ; owl:annotatedTarget "Decreased Hb concentration" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37176 ; owl:annotatedTarget "mononuclear parent hydrides" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020062 ; owl:annotatedTarget "Decreased haemoglobin concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020063 ; owl:annotatedTarget "Increased Hb concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020063 ; owl:annotatedTarget "Increased haemoglobin concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37176 ; owl:annotatedTarget "mononuclear hydride" . [] oboInOwl:hasDbXref "PMID:24023426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020073 ; owl:annotatedTarget "A white or lighter patch of skin that may appear anywhere on the body and are caused by decreased skin pigmentation." . [] oboInOwl:hasDbXref "PMID:26509782" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020074 ; owl:annotatedTarget "The presence of crystals in the urine." . [] oboInOwl:hasDbXref "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020075 ; owl:annotatedTarget "The presence of leucine crystals in the urine." . [] oboInOwl:hasDbXref "PMID:17488856", "PMID:19468907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020076 ; owl:annotatedTarget "A benign soft tissue tumor of the wrist usually found in the dorsal aspect of the wrist and communicate with the joint via a pedicle. This pedicle usually originates not only at the scapholunate ligament, but also may arise from a number of other sites over the dorsal aspect of the wrist capsule." . [] oboInOwl:hasDbXref , "PMID:11196742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020077 ; owl:annotatedTarget "An elevated level of carnitine in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020078 ; owl:annotatedTarget "An increased level of alanine in the urine." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37176 ; owl:annotatedTarget "mononuclear hydrides" . [] oboInOwl:hasDbXref "PMID:15054821", "PMID:21250106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020081 ; owl:annotatedTarget "A type of erythrocyte inclusion characterized by basophilic stippling of erythrocytes, that is, by numerous very small coarse or fine blue granules within the cytoplasm with the additional stipulation that the stippled particles are due to iron granules (demonstrable by the Prussian blue stain)." . [] oboInOwl:hasDbXref "PMID:21250106", "PMID:24713708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020082 ; owl:annotatedTarget "A type of erythrocyte inclusion composed of denatured hemoglobin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020083 ; owl:annotatedTarget "Boil" . [] oboInOwl:hasDbXref "PMID:32119346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020084 ; owl:annotatedTarget "A pustular lesion of the skin emerging from group of infected hair follicles, characterized by a deep location and dissecting through tissue planes. A carbuncle is larger and deeper than a furuncle." . [] oboInOwl:hasDbXref "PMID:24722620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020086 ; owl:annotatedTarget "Local or regional infection with Bacillus Calmette-Guerin (BCG) following vaccination." . [] oboInOwl:hasDbXref "PMID:21412596", "PMID:24722620" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020087 ; owl:annotatedTarget "Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis." . [] oboInOwl:hasDbXref "PMID:29152266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020088 ; owl:annotatedTarget "Infection with the measles virus of the live-attenuated vaccine. This is an extremely rare event and may indicate immunocompromise in some cases." . [] oboInOwl:hasDbXref "PMID:25285130" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020090 ; owl:annotatedTarget "Infection with live attenuated polio vaccine following vaccination. This is an extreemely rare event that may indicate immunocompromise." . [] oboInOwl:hasDbXref "PMID:21477676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020091 ; owl:annotatedTarget "Infection with live attenuated rotavirus vaccine following vaccination." . [] oboInOwl:hasDbXref "PMID:30515161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020097 ; owl:annotatedTarget "An infection by an encapsulated bacterial agent. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines." . [] oboInOwl:hasDbXref "PMID:25567225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020099 ; owl:annotatedTarget "An unusually severe course of infection with Human norovirus, previously known as Norwalk virus. Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen. Norovirus infection-associated illness may also be more prolonged and severe in immunocompromised individuals and may be associated with remarkably persistent viral excretion in some of these individuals." . [] oboInOwl:hasDbXref "PMID:24718393" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020101 ; owl:annotatedTarget "Fungal infection characterized by invasion of host tissues." . [] oboInOwl:hasDbXref "PMID:26281787" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020102 ; owl:annotatedTarget "An opportunistic disease caused by invasion of unicellular fungus Pneumocystis jirovecii. Transmission of P. jirovecii cysts takes place through the airborne route, and usually, its presence in lungs is asymptomatic. However, people with impaired immunity, especially those with CD4+ T cell count below 200/microliter, are still at risk of the development of Pneumocystis pneumonia due to P. jirovecii invasion. Symptoms induced by this disease are not specific: progressive dyspnoea, non-productive cough, low-grade fever, arterial partial pressure of oxygen below 65 mmHg, and chest radiographs demonstrating bilateral, interstitial shadowing." . [] oboInOwl:hasDbXref "PMID:25656673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020103 ; owl:annotatedTarget "Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis." . [] oboInOwl:hasDbXref "PMID:25762774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020105 ; owl:annotatedTarget "Toxoplasmosis is a widespread parasitic infection that is frequently asymptomatic in immunocompetent patients. However, this obligate intracellular protozoan parasite can evade the immune system and persist for the life of its host in cyst form, predominantly in the brain, retina, and muscles. Reactivation of latent cysts may occur when the immune system fails to maintain cytokine pressure, which mainly relies on gamma interferon (IFN-gamma). Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs)." . [] oboInOwl:hasDbXref "PMID:11148005", "PMID:17042927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020106 ; owl:annotatedTarget "An unusually severe infection due to Giardia lamblia, also called Giardia duodenalis or Giardia intestinalis, which is a protozoan parasite of the small intestine that causes extensive morbidity worldwide." . [] oboInOwl:hasDbXref "PMID:18382743" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020107 ; owl:annotatedTarget "An unusual helminthic infection that is regarded as a sign of a pathological susceptibility to infection by a worm (helminth)." . [] oboInOwl:hasDbXref "PMID:16148530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020108 ; owl:annotatedTarget "An unusual parasitic infection that is regarded as a sign of a pathological susceptibility to infection by a parasite." . [] oboInOwl:hasDbXref "WHO_MedNet" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15551 ; owl:annotatedTarget "dinoprostonum" . [] oboInOwl:hasDbXref "PMID:19751267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020111 ; owl:annotatedTarget "A deviation from the normal proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "Beilstein:3669982" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "PMID:5130448" . [] oboInOwl:hasDbXref "PMID:24643184", "PMID:26239127" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020114 ; owl:annotatedTarget "Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease." . [] oboInOwl:hasDbXref "PMID:11851880", "PMID:25487405" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020117 ; owl:annotatedTarget "Underdeveloped hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin." . [] oboInOwl:hasDbXref "PMID:24650137" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020118 ; owl:annotatedTarget "Congenital absence of the radial artery." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020119 ; owl:annotatedTarget "Abnormal retinal nerve fibre layer morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020120 ; owl:annotatedTarget "Retinal nerve fibre oedema" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "Reaxys:3669982" . [] oboInOwl:hasDbXref "PMID:28844405" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020121 ; owl:annotatedTarget "A history of conception by an assisted reproductive technology such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation." . [] oboInOwl:hasDbXref "ISBN:978-0-07174889-6" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020122 ; owl:annotatedTarget "Red blood cells that appear to have parts of them bitten away." . [] oboInOwl:hasDbXref "PMID:27656306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020123 ; owl:annotatedTarget "A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear." . [] oboInOwl:hasDbXref "PMID:24768550", "PMID:8749053" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020125 ; owl:annotatedTarget "Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020125 ; owl:annotatedTarget "Conjunctival avascular cysts (filtering blebs)" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "3,7,11,15-tetramethylhexadecanoate" . [] oboInOwl:hasDbXref , "PMID:27863011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020128 ; owl:annotatedTarget "Aplasia (congenital absence) of the olfactory tract, which causes anosmia, a complete loss of the sense of smell." . [] oboInOwl:hasDbXref "PMID:18725016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020130 ; owl:annotatedTarget "An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020130 ; owl:annotatedTarget "Increased urinary NGAL" . [] oboInOwl:hasDbXref "PMID:20142905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020132 ; owl:annotatedTarget "Increase in thickness of the basement membrane of the tubulus of the kidney." . [] oboInOwl:hasDbXref "PMID:15610239", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020133 ; owl:annotatedTarget "Increased visceral epithelial cell size, with or without cytoplasmic protein droplets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020134 ; owl:annotatedTarget "Abnormally increased count of neutrophils in urine." . [] oboInOwl:hasDbXref "NCIT:C3742", "PMID:29364448" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020135 ; owl:annotatedTarget "A mesenchymal neoplasm characterized by solitary or multiple nodules involving the skin, striated muscles, bones and, sometimes, viscera. It usually appears as a subcutaneous nodule, but can also appear as an ulcer, pedunculated lesion, or similar to a hemangioma. Histology shows well-circumscribed tapered cell lobes, resembling smooth muscle cells. At its center, perivascular round cells (hemangiopericitoides) are usually observed, giving a biphasic appearance." . [] oboInOwl:hasDbXref "PMID:30256771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020136 ; owl:annotatedTarget "The presence of circulating IgG autoantibodies to cardiolipin." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "3,7,11,15-tetramethylhexadecanoate" . [] oboInOwl:hasDbXref "PMID:30256771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020137 ; owl:annotatedTarget "The presence of circulating IgM autoantibodies to cardiolipin." . [] oboInOwl:hasDbXref "PMID:26179017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020138 ; owl:annotatedTarget "Medical history of a recent bite injury due to an animal." . [] oboInOwl:hasDbXref "PMID:24364549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020139 ; owl:annotatedTarget "Medical history of a recent bite injury due to an insect." . [] oboInOwl:hasDbXref "PMID:24364549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020140 ; owl:annotatedTarget "Medical history of a recent bite injury due to a tick." . [] oboInOwl:hasDbXref "PMID:12101189" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020141 ; owl:annotatedTarget "An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the legs being much higher than the blood pressure measure in the arms. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm." . [] oboInOwl:hasDbXref "PMID:28377475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020142 ; owl:annotatedTarget "An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the arms being much higher than the blood pressure measure in the legs. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm." . [] oboInOwl:hasDbXref "PMID:25313910" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020143 ; owl:annotatedTarget "A cyst in the trachea, whose wall is made up by tissue similar to the bronchial tree, including cartilage and smooth muscle, and is lined by secretory respiratory epithelium composed of cuboid or columnar ciliated epithelium." . [] oboInOwl:hasDbXref "PMID:26509782", "PMID:3599249", "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020144 ; owl:annotatedTarget "The presence of calcium phosphate crystals in the urine." . [] oboInOwl:hasDbXref "PMID:26509782", "PMID:3599249", "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020145 ; owl:annotatedTarget "The presence of calcium oxalate crystals in the urine." . [] oboInOwl:hasDbXref "PMID:26509782", "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020146 ; owl:annotatedTarget "The presence of calcium carbonate crystals in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "3,7,11,15-tetramethylpalmitate" . [] oboInOwl:hasDbXref , "PMID:17883863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020147 ; owl:annotatedTarget "Increased concentration of 2-methylbutyryl glycine in the urine." . [] oboInOwl:hasDbXref "PMID:25440954" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020148 ; owl:annotatedTarget "An abnormally elevated concentration od mead acid in the blood circulation." . [] oboInOwl:hasDbXref "PMID:29434314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020149 ; owl:annotatedTarget "An increase concentration of succinate in the blood circulation." . [] oboInOwl:hasDbXref "PMID:28781372" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020150 ; owl:annotatedTarget "The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:15804704" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020151 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA." . [] oboInOwl:hasDbXref "PMID:27475024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020153 ; owl:annotatedTarget "Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis." . [] oboInOwl:hasDbXref "PMID:23888253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020154 ; owl:annotatedTarget "A type of epidermal nevus characterized by closely arranged, dilated follicular openings with keratinous plugs resembling classical comedones." . [] oboInOwl:hasDbXref "PMID:26329136" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020156 ; owl:annotatedTarget "Abnormal structure of the oocyte extracellular matrix region known as teh zona pellucida." . [] oboInOwl:hasDbXref "PMID:7657763" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020157 ; owl:annotatedTarget "Reduced thickness of the zona pellucida." . [] oboInOwl:hasDbXref , "PMID:28456640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020158 ; owl:annotatedTarget "An increased concentration of adrenic acid (also known as cis-7,10,13,16-Docosatetraenoic acid) in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37257 ; owl:annotatedTarget "phytanate anion" . [] oboInOwl:hasDbXref "PMID:22723321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020159 ; owl:annotatedTarget "Failure of the gonadotropin-releasing hormone (GnRH) stimulation test to induce an appropriate increased in luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0020159 ; owl:annotatedTarget "Reduce response to GnRH stimulation test" . [] oboInOwl:hasDbXref "PMID:9063740" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020160 ; owl:annotatedTarget "Cellular accumulation of GM1 gangliosides." . [] oboInOwl:hasDbXref , "PMID:19376586" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020161 ; owl:annotatedTarget "Blockage of a branch of the retinal artery. This can cause loss of a section of visual field." . [] oboInOwl:hasDbXref , "PMID:28058169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020163 ; owl:annotatedTarget "Blockage of the cilioretinal artery. The central retinal artery supplies the inner retina and the surface of the optic nerve. In some individuals, the cilioretinal artery, a branch of the ciliary circulation, may supply a portion of the retina including the macula. In cilioretinal artery occlusion, vision loss results from cell death in the inner retinal layers (mainly ganglion cells) despite relative sparing of the outer layers." . [] oboInOwl:hasDbXref , "PMID:30148234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020164 ; owl:annotatedTarget "A partial or complete obstruction of the ophthalmic artery (branch of the internal carotid artery) that may lead to severe ischemia of the affected globe and associated ocular tissues. It can present with a similar picture to central retinal artery occlusion; however, profound choroidal ischaemia also occurs." . [] oboInOwl:hasDbXref , "PMID:30570991" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020165 ; owl:annotatedTarget "Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels." . [] oboInOwl:hasDbXref "PMID:30252241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020166 ; owl:annotatedTarget "Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis." . [] oboInOwl:hasDbXref , "PMID:22069354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020167 ; owl:annotatedTarget "A variant of central retinal vein occlusions that involves the superior or inferior half of the retina." . [] oboInOwl:hasDbXref , "PMID:16948615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020169 ; owl:annotatedTarget "An anomalous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "Mucopolysaccharide" . [] oboInOwl:hasDbXref , "PMID:26075072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020170 ; owl:annotatedTarget "High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime." . [] oboInOwl:hasDbXref , "PMID:26075072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020171 ; owl:annotatedTarget "Low plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime." . [] oboInOwl:hasDbXref , "PMID:11072960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020172 ; owl:annotatedTarget "An unpleasant or harmful reaction resulting from treatment with a drug." . [] oboInOwl:hasDbXref , "PMID:26178435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020173 ; owl:annotatedTarget "Decreased response to a drug intervention in comparison to the expected response." . [] oboInOwl:hasDbXref , "PMID:29188449" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020174 ; owl:annotatedTarget "Absent or significantly reduced efficacy of drug intervention characterized by lack of measurable benefit or deterioration of disease course." . [] oboInOwl:hasDbXref , "PMID:29853783" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020175 ; owl:annotatedTarget "A decreased amount of cholinesterase in the blood circulation." . [] oboInOwl:hasDbXref "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020176 ; owl:annotatedTarget "The presence of cholesterol crystals in the urine." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "mucopolysaccharides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "Mucopolysaccharid" . [] oboInOwl:hasDbXref "CL:0000451", "PMID:15795906" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020178 ; owl:annotatedTarget "A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." . [] oboInOwl:hasDbXref "PMID:24809098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020179 ; owl:annotatedTarget "A deviation from the normal concentration of haptoglobin in the blood circulation." . [] oboInOwl:hasDbXref "PMID:24809098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020180 ; owl:annotatedTarget "An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation." . [] oboInOwl:hasDbXref "PMID:24809098" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020181 ; owl:annotatedTarget "An abnormally low concentration of haptoglobin in the blood circulation. Decreased haptoglobin in conjunction with increased reticulocyte count and anemia may indicate hemolysis. Decreased haptoglobin levels can also occur in the absence of hemolysis, due to cirrhosis of the liver, disseminated ovarian carcinomatosis, pulmonary sarcoidosis, and elevated estrogen state." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_SJWang", "PMID:28552863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020182 ; owl:annotatedTarget "A measurable change in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_SJWang", "PMID:28552863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020183 ; owl:annotatedTarget "A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_SJWang", "PMID:28552863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020184 ; owl:annotatedTarget "A measurable reduction in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure." . [] oboInOwl:hasDbXref "PMID:23710135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020186 ; owl:annotatedTarget "The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen." . [] oboInOwl:hasDbXref "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020187 ; owl:annotatedTarget "Pachygyria with a very thick cerebral cortex measuring 10-20 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age." . [] oboInOwl:hasDbXref , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020188 ; owl:annotatedTarget "Pachygyria with cortical thickness between 5 and 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically over 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "Mukopolysaccharid" . [] oboInOwl:hasDbXref , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020189 ; owl:annotatedTarget "Pachygyria with cortical thickness above 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." . [] oboInOwl:hasDbXref , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020190 ; owl:annotatedTarget "Pachygyria with cortical thickness greater than 10 mm and a perisylvian predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Perisylvian predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020191 ; owl:annotatedTarget "Pachygyria with cortical thickness greater than 10 mm and an anterior predominant severity gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Anterior predominant gradient indicates pachygyria more severe over the frontal and temporal lobes." . [] oboInOwl:hasDbXref , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020192 ; owl:annotatedTarget "Pachygyria with a mildly thickend cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age." . [] oboInOwl:hasDbXref "PMID:23546720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020193 ; owl:annotatedTarget "An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds." . [] oboInOwl:hasDbXref "PMID:25125965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020194 ; owl:annotatedTarget "An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." . [] oboInOwl:hasDbXref "PMID:22301495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020195 ; owl:annotatedTarget "An abnormal IgG heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." . [] oboInOwl:hasDbXref "PMID:17403946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020196 ; owl:annotatedTarget "An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." . [] oboInOwl:hasDbXref , "PMID:30034875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020197 ; owl:annotatedTarget "An increased circulation of arachidonic acid in the blood circulation." . [] oboInOwl:hasDbXref "PMID:2669615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020198 ; owl:annotatedTarget "Any deviation from the normal concentration of 18-Hydroxycorticosterone level in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "mucopolisacarido" . [] oboInOwl:hasDbXref "PMID:22238407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020200 ; owl:annotatedTarget "An abnormally elevated concentration of 18-Hydroxycorticosterone level in the blood circulation." . [] oboInOwl:hasDbXref "PMID:22028589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020202 ; owl:annotatedTarget "Any structural anomaly of the Z disc, which is the platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." . [] oboInOwl:hasDbXref "PMID:1180479", "PMID:22028589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020203 ; owl:annotatedTarget "Streaming or smearing of the Z band, which is then no longer confined to a narrow zone which bisects the I band. The Z disc may extend across the I band or the entire sarcomere in a zigzag manner. Focal thickening, smudging, and blurring of the Z band takes place concurrently. Myofibrillar disorganization is a frequent but not invariable accompanying change." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020204 ; owl:annotatedTarget "Tubulointerstitial infiltration of bacteria identified on routine and/or special (Brown-Hopps) stains." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020205 ; owl:annotatedTarget "Tubulointerstitial infiltration of yeast or hyphal-microrganisms identified on routine and/or special (PAS, silver) stains." . [] oboInOwl:hasDbXref "PMID:15523657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020206 ; owl:annotatedTarget "The pinna has fewer folds and grooves than usual." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020207 ; owl:annotatedTarget "Seizures precipitated by exogenous stimuli." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020208 ; owl:annotatedTarget "A seizure precipitated by aspects of anticipating food, eating itself, or the post-prandial period." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020209 ; owl:annotatedTarget "A seizure precipitated by pouring cupfuls of very hot water (40 to 50 degrees Celsius) in rapid succession over the head. Bathing in this manner is the most common trigger." . [] oboInOwl:hasDbXref , "PMID:11422340", "PMID:24512781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020210 ; owl:annotatedTarget "A seizure precipitated by complex, cognition-guided tasks often involving visuomotor coordination and decision-making." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37395 ; owl:annotatedTarget "mucopolisacaridos" . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020211 ; owl:annotatedTarget "A seizure precipitated by movement or a change in posture." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020212 ; owl:annotatedTarget "A seizure precipitated by reading." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020213 ; owl:annotatedTarget "A somatosensory reflex seizure is a seizure precipitated by somatic stimulation of a specific part of the body in the absence of startle or surprise." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020214 ; owl:annotatedTarget "Startle-induced seizures are triggered by multiple and non-specific stimuli (auditory, somatosensory, and rarely visual) and are characterized by their sudden unexpected nature. Sudden noise rather than pure sound is the most effective acoustic stimulus." . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020215 ; owl:annotatedTarget """Seizures induced by thinking and decision-making. comment:""" . [] oboInOwl:hasDbXref , "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020216 ; owl:annotatedTarget "Seizures evoked by visual stimuli. This includes clinical seizures induced by strobe lighting, television and other screens, flickering environmental lighting and self-induction by causing a strobe effect." . [] oboInOwl:hasDbXref , "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020217 ; owl:annotatedTarget "A type of focal motor seizure in which awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref , "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020218 ; owl:annotatedTarget "A type of focal atonic seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref , "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020219 ; owl:annotatedTarget "A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." . [] oboInOwl:hasDbXref , "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020220 ; owl:annotatedTarget "A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature." . [] oboInOwl:hasDbXref , "PMID:11580774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020221 ; owl:annotatedTarget "A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive." . [] oboInOwl:hasDbXref "PMID:29018201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020222 ; owl:annotatedTarget "A decreased concentration of homocystine in the blood." . [] oboInOwl:hasDbXref "PMID:31484633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0020223 ; owl:annotatedTarget "A dermal sinus tract is an abnormality present at birth over the dorsal midline where an abnormal epithelialized connection from the skin tracks inwards towards the spine, most commonly seen in the lumbosacral region." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "CAS:9007-28-7" . [] oboInOwl:hasDbXref , "PMID:24649409" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025004 ; owl:annotatedTarget "Osteoarthritis of the metatarsophalangeal joint of the first toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025004 ; owl:annotatedTarget "Arthritis of the big toe" . [] oboInOwl:hasDbXref , "PMID:6879730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025005 ; owl:annotatedTarget "Widening of the wall of capillary blood vessels in the glomerulus. This feature may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025008 ; owl:annotatedTarget "Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025010 ; owl:annotatedTarget "Partial or complete loss of foveal tissue that was once present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025011 ; owl:annotatedTarget "Narrowing of the anterior nasal aperture (piriform or pyriform aperture), which is a pear-shaped opening in the skull that forms the bony inlet of the nose." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025012 ; owl:annotatedTarget "Diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025013 ; owl:annotatedTarget "A type of rigidity that is manifested by an exaggerated extensor posture of all extremities." . [] oboInOwl:hasDbXref "PMID:20847697" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025014 ; owl:annotatedTarget "Small, hard cyst-like nodules, freely moveable in the subcutis over the bony prominences of the legs and arms, which have an outer calcified layer with a translucent core on x-ray." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "CAS:9007-28-7" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "PMID:11514091" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "PMID:7538297" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025019 ; owl:annotatedTarget "Sudden breakage of an artery leading to leakage of blood from the circulation." . [] oboInOwl:hasDbXref "PMID:26366236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025020 ; owl:annotatedTarget "An increased concentration of prostate specific antigen (PSA) in the circulation." . [] oboInOwl:hasDbXref "PMID:10524488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025021 ; owl:annotatedTarget "A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling." . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025021 ; owl:annotatedTarget "Abnormal ESR" . [] oboInOwl:hasDbXref "PMID:10524488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025022 ; owl:annotatedTarget "A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025022 ; owl:annotatedTarget "Decreased ESR" . [] oboInOwl:hasSynonymType hp:abbreviation, hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025022 ; owl:annotatedTarget "Low ESR" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "Chondroitin sulfate" . [] oboInOwl:hasDbXref , "PMID:20006038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025023 ; owl:annotatedTarget "A developmental defect resulting in complete obliteration of the lumen of the rectum. That is, there is an abnormal closure, or atresia of the tubular structure of the rectum." . [] oboInOwl:hasDbXref , "PMID:10869000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025024 ; owl:annotatedTarget "An abnormal dilation of the rectum. There is a large filled rectum as a result of underlying innervation or muscular abnormalities, which remains after disimpaction of the rectum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025025 ; owl:annotatedTarget "A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening." . [] oboInOwl:hasDbXref "PMID:20223314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025026 ; owl:annotatedTarget "Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract." . [] oboInOwl:hasDbXref , "PMID:21152797", "PMID:26273166" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025027 ; owl:annotatedTarget "The term osteoma refers to the anomalous presence of ossification (bone formation) in the interior of the dermis or epidermis. The dermal or subcutaneous bone formation presents as stony hard nodules. The osteomata appear as irregular, hardened small nodules that are well circumscribed and generally of the same color as the skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "Chondroitinsulfat" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "chondroitin polysulfate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "chondroitin sulfates" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "chondroitin sulfuric acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37397 ; owl:annotatedTarget "chondroitin sulphate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37445 ; owl:annotatedTarget "folates" . [] oboInOwl:hasDbXref , "PMID:26530930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025037 ; owl:annotatedTarget "Focal proliferation of glial cells in the hypothalamus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37445 ; owl:annotatedTarget "folate" . [] oboInOwl:hasDbXref "PMID:11598263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025038 ; owl:annotatedTarget "A collection of pus within a testicle. Ultrasonographic features include shaggy, irregular walls, intratesticular location, low-level internal echoes, and occasionally, hypervascular margins." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37445 ; owl:annotatedTarget "folates" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "Acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "Saeure" . [] oboInOwl:hasDbXref "PMID:26366400" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025044 ; owl:annotatedTarget "A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity." . [] oboInOwl:hasDbXref "PMID:12557293", "PMID:15625559" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025051 ; owl:annotatedTarget "A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "Saeuren" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "acide" . [] oboInOwl:hasDbXref "PMID:21319348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025059 ; owl:annotatedTarget "A circumscribed area of pus or necrotic debris in the parenchyma of the spleen." . [] oboInOwl:hasDbXref "PMID:23816735" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025062 ; owl:annotatedTarget "The practice of eating earth or soil-like substrates such as clay or chalk." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "acido" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025065 ; owl:annotatedTarget "Abnormal MCV" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025066 ; owl:annotatedTarget "Decreased MCV" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025068 ; owl:annotatedTarget "Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort." . [] oboInOwl:hasDbXref "PMID:22665396" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025070 ; owl:annotatedTarget "An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3." . [] oboInOwl:hasDbXref "PMID:22665396" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025073 ; owl:annotatedTarget "U wave inversion that is induced by exercise stress testing." . [] oboInOwl:hasDbXref "PMID:8222799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025078 ; owl:annotatedTarget "The QRS complexes of the electrocardiogram alternate in height." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37527 ; owl:annotatedTarget "acids" . [] oboInOwl:hasDbXref "PMID:24701633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025081 ; owl:annotatedTarget "A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP." . [] oboInOwl:hasDbXref "PMID:12082143", "PMID:21738362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025082 ; owl:annotatedTarget "Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025082 ; owl:annotatedTarget "Abnormal cutaneous elastic fibre morphology" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37577 ; owl:annotatedTarget "chemical compound" . [] oboInOwl:hasDbXref "PMID:2307214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025083 ; owl:annotatedTarget "An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0025085 ; owl:annotatedTarget "Blood in stool" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0025085 ; owl:annotatedTarget "Bloody stool" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025085 ; owl:annotatedTarget "Bloody bowel movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025085 ; owl:annotatedTarget "Bloody diarrhea" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025085 ; owl:annotatedTarget "Bloody diarrhoea" . [] oboInOwl:hasDbXref "PMID:24882996", "PMID:25473242", "PMID:28207011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025088 ; owl:annotatedTarget "Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025089 ; owl:annotatedTarget "Faecal vomiting" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025089 ; owl:annotatedTarget "Vomiting faecal matter" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025092 ; owl:annotatedTarget "Thickening of upper layer of skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37577 ; owl:annotatedTarget "heteroatomic molecular entities" . [] oboInOwl:hasDbXref "PMID:17388999" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025096 ; owl:annotatedTarget "Unprovoked explosive pathological sneezing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37578 ; owl:annotatedTarget "halides" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37622 ; owl:annotatedTarget "carboxamides" . [] oboInOwl:hasDbXref "PMID:24050295" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025103 ; owl:annotatedTarget "A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated)." . [] oboInOwl:hasDbXref "PMID:22483320", "PMID:25864701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025104 ; owl:annotatedTarget "A capillary malformation is a flat, sharply defined vascular stain of the skin. It may cover a large surface area or it may be scattered and appear as little islands of color. In a capillary maformation, the predominant vessels are small, slow-flow vessels (i.e., arterioles and postcapillary venules)." . [] oboInOwl:hasDbXref "PMID:22483320", "PMID:25864701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025105 ; owl:annotatedTarget "A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anaemic spots." . [] oboInOwl:hasDbXref "PMID:22483320", "PMID:25864701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025106 ; owl:annotatedTarget "A variant of port-wine stain characterized by a pale red or even pink tone, in contrast to the darker hue of the port-wine stain. By analogy with the term port-wine stain, this variant rose-wine stain, or nevus roseus. Nevus roseus, however, cannot be definitely diagnosed until adulthood as port-wine stains are sometimes pink in children. While the natural history of port-wine stains includes hypertrophy, darkening, and nodularity, nevus roseus remains unchanged for life." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37622 ; owl:annotatedTarget "carboxamides" . [] oboInOwl:hasDbXref "PMID:22483320", "PMID:25864701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025107 ; owl:annotatedTarget "A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible." . [] oboInOwl:hasDbXref "PMID:25864701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025108 ; owl:annotatedTarget "Angioma serpiginosum consists of punctate, tightly packed telangiectatic lesions. Characteristic histopathological features are dilated and tortuous capillaries involving the uppermost part of the dermis." . [] oboInOwl:hasDbXref "PMID:7949104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025109 ; owl:annotatedTarget "Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025112 ; owl:annotatedTarget "Noise sensitivity" . [] oboInOwl:hasDbXref "PMID:23919028" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025115 ; owl:annotatedTarget "Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025116 ; owl:annotatedTarget "Foetal distress" . [] oboInOwl:hasDbXref "PMID:20548894" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025117 ; owl:annotatedTarget "Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance." . [] oboInOwl:hasDbXref "PMID:24346922" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025119 ; owl:annotatedTarget "An alteration of the color of the lip to take on a violet color. This term does not include cyanosis." . [] oboInOwl:hasDbXref "PMID:19061615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025122 ; owl:annotatedTarget "A type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37622 ; owl:annotatedTarget "primary carboxamide" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37624 ; owl:annotatedTarget "Beilstein:1724626" . [] oboInOwl:hasDbXref "PMID:16269085", "PMID:19946526", "PMID:24758199", "PMID:9715244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025131 ; owl:annotatedTarget "Enlargement of the soft tissues of one or more fingers." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025131 ; owl:annotatedTarget "Swelling of fingers" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025131 ; owl:annotatedTarget "Swollen finger" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37624 ; owl:annotatedTarget "CAS:921-60-8" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025132 ; owl:annotatedTarget "Abnormal oestrogen level" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37624 ; owl:annotatedTarget "L-gluco-hexose" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37624 ; owl:annotatedTarget "L-glucose" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37624 ; owl:annotatedTarget "L(-)-glucose" . [] oboInOwl:hasDbXref "PMID:25928877" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025141 ; owl:annotatedTarget "Ectopic deposition of calcium salts found in the gingiva." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025143 ; owl:annotatedTarget "Chills" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37627 ; owl:annotatedTarget "Beilstein:2206321" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025144 ; owl:annotatedTarget "Shivering" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025144 ; owl:annotatedTarget "Shuddering" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025145 ; owl:annotatedTarget "Rigours" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37627 ; owl:annotatedTarget "Reaxys:2206321" . [] oboInOwl:hasDbXref "PMID:27739528", "PMID:7248243" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025148 ; owl:annotatedTarget "A fluorescein angiographic finding of absence of the normal background fluorescence (a dark choroid)." . [] oboInOwl:hasDbXref "PMID:18329691" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025149 ; owl:annotatedTarget "Partial or complete wasting (loss) of muscularois propria tissue that was once present. The atrophy may involve a marked vacuolar degeneration of myocytes, loss of muscle fibers and some cases a highly characteristic honeycomb fibrosis." . [] oboInOwl:hasDbXref "PMID:26361414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025151 ; owl:annotatedTarget "Hyperplastic submucosal and myenteric plexus containing an increased number of ganglion cells, glial cells and nerve fibers." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37627 ; owl:annotatedTarget "L-glucopyranose" . [] oboInOwl:hasDbXref "PMID:16770168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025156 ; owl:annotatedTarget "Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025156 ; owl:annotatedTarget "Dependency on IV nutrition" . [] oboInOwl:hasDbXref "PMID:25072684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025164 ; owl:annotatedTarget "An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37627 ; owl:annotatedTarget "L-glucopyranose" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025164 ; owl:annotatedTarget "Increased number of elastic fibres in the dermis" . [] oboInOwl:hasDbXref "PMID:25072684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025165 ; owl:annotatedTarget "Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025165 ; owl:annotatedTarget "Clumping of elastic fibres in the dermis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025166 ; owl:annotatedTarget "Thickened elastic fibres in the dermis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025167 ; owl:annotatedTarget "Fragmented elastic fibres in the dermis" . [] oboInOwl:hasDbXref "PMID:12527689", "PMID:14594874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025168 ; owl:annotatedTarget "Abnormal function of the left ventricule during left ventricular relaxation and filling." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025170 ; owl:annotatedTarget "Glioneuronal tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025170 ; owl:annotatedTarget "Neuronal and mixed neuronal-glial tumour" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025170 ; owl:annotatedTarget "Neuronal/glioneuronal neoplasm of the CNS" . [] oboInOwl:hasDbXref "PMID:27179225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025171 ; owl:annotatedTarget "A tumor of the central nervous system that has components of both neurocytic and glial areas, whereby usually the glial component of the tumor predominates. Rossette-forming glioneuronal tumors (RGNT) have biphasic cytoarchitecture with two elements; neurocytic rosettes resembling Homer-Wright rosettes, and astrocytic component resembling a pilocytic astrocytoma. RGNTs are low-grade tumors that lack histopathological signs of malignancy." . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37627 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0025171 ; owl:annotatedTarget "Rosette-forming glioneuronal tumour of the fourth ventricle" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025175 ; owl:annotatedTarget "Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care." . [] oboInOwl:hasDbXref "PMID:18195376", "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025179 ; owl:annotatedTarget """On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.""" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025179 ; owl:annotatedTarget "GGO" . [] oboInOwl:hasDbXref "PMID:22526827" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025181 ; owl:annotatedTarget "An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025182 ; owl:annotatedTarget "Localised area of pendulous skin" . [] oboInOwl:hasDbXref "PMID:23345532", "PMID:25754805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025186 ; owl:annotatedTarget "Unilateral ptosis with associated upper eyelid contraction and contraction of either the external or the internal pterygoid muscle. It is thought to occur because of congenital miswiring of a branch of the fifth cranial nerve into the branch of the third cranial nerve supplying the levator muscle. In Marcus Gunn jaw winking synkinesis, elevation and even retraction of the affected eyelid is triggered by chewing, suction, lateral mandible movement, smiling, sternocleidomastoid contraction, protruding tongue, Valsalva manoeuvre and even by breathing." . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:28276060", "PMID:28276064", "PMID:6790275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025190 ; owl:annotatedTarget "A bilateral tonic-clonic seizure with generalized onset is a type of bilateral tonic-clonic seizure characterised by generalized onset; these seizures rapidly engage networks in both hemispheres at the start of the seizure." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025190 ; owl:annotatedTarget "Bilateral tonic-clonic seizure with generalised onset" . [] oboInOwl:hasDbXref "PMID:3542299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025196 ; owl:annotatedTarget "An elevation in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. A high TIBC corresponds to a high transferrin concentration. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity." . [] oboInOwl:hasDbXref "NCIT:C3456", "PMID:27684985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025197 ; owl:annotatedTarget "A benign tumor made up of mostly myofibroblasts that appears almost exclusively on the digits of the hands and feet, rarely involving the thumb or big toe. The lesion displays a proliferation of bland intradermal spindle cells arranged in whorls, fascicles, or a storiform pattern in a collagenous background of varying degrees. Also usually present are perpendicular tumor cell fascicles that extend to the epidermis. The small intracytoplasmic inclusions are said to appear similar to red blood cells. The inclusion bodies have been shown to be made up of densely packed vimentin and actin filaments. The tumor often causes a dome-shaped elevation of the overlying structures, forming a protuberant or polypoid nodule. The overlying epidermis can display a host of changes, including acanthosis, hyperkeratosis, parakeratosis, rete ridge flattening, entrapment of adnexal structures, and, rarely, ulceration." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025197 ; owl:annotatedTarget "Digital fibrous tumour of Reye" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025200 ; owl:annotatedTarget "Muscle fibre actin filament accumulation" . [] oboInOwl:hasDbXref "PMID:26112857" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025203 ; owl:annotatedTarget "Distended and engorged umbilical veins which are seen radiating from the umbilicus across the abdomen to join systemic veins." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025205 ; owl:annotatedTarget "Triggered by breastfeeding" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025206 ; owl:annotatedTarget "Triggered by cold temperature" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025207 ; owl:annotatedTarget "Triggered by dehydration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025208 ; owl:annotatedTarget "Triggered by carbohydrate ingestion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025209 ; owl:annotatedTarget "Trigged by fruit sugar" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0025211 ; owl:annotatedTarget "Triggered by alcohol ingestion" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37631 ; owl:annotatedTarget "Beilstein:1907373" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025212 ; owl:annotatedTarget "Triggered by fasting" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025213 ; owl:annotatedTarget "Triggered by ingestion of lactose-containing milk" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025214 ; owl:annotatedTarget "Triggered by heat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025215 ; owl:annotatedTarget "Triggered by fever" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025216 ; owl:annotatedTarget "Triggered by overeating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025217 ; owl:annotatedTarget "Triggered by high-fat diet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025218 ; owl:annotatedTarget "Triggered by hyperventilation" . [] oboInOwl:hasDbXref "PMID:26633955" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025219 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by a vaccination." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025219 ; owl:annotatedTarget "Triggered by immunisation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025219 ; owl:annotatedTarget "Triggered by vaccination" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37631 ; owl:annotatedTarget "Reaxys:1907373" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025220 ; owl:annotatedTarget "Triggered by monthly period" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025220 ; owl:annotatedTarget "Triggered by period" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025221 ; owl:annotatedTarget "Triggered by pregnancy" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025222 ; owl:annotatedTarget "Triggered by sleep deprivation" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025223 ; owl:annotatedTarget "Triggered by cigarette consumption" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025223 ; owl:annotatedTarget "Triggered by smoking" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025223 ; owl:annotatedTarget "Triggered by tobacco use" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025224 ; owl:annotatedTarget "Triggered by Na ingestion" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025224 ; owl:annotatedTarget "Triggered by Na+ ingestion" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0025224 ; owl:annotatedTarget "Triggered by salt ingestion" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37631 ; owl:annotatedTarget "beta-L-glucopyranose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025225 ; owl:annotatedTarget "Triggered by sound" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025226 ; owl:annotatedTarget "Triggered by stress" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025227 ; owl:annotatedTarget "Triggered by excitement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025228 ; owl:annotatedTarget "Triggered by sudden movement" . [] oboInOwl:hasDbXref "PMID:21571556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025233 ; owl:annotatedTarget "An inability to move the body at sleep onset or upon awakening from sleep lasting seconds to a few minutes." . [] oboInOwl:hasDbXref "PMID:27647645" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025234 ; owl:annotatedTarget "An undesirable physical event or experience that occurs during entry into sleep, during sleep, or during arousal from sleep." . [] oboInOwl:hasDbXref "PMID:27647645" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025235 ; owl:annotatedTarget "A parasomnia that occurs in non-rapid eye movement (NREM) sleep. This refers to a disorder of arousal that occurs during slow-wave sleep (ie, NREM stage 3 sleep)." . [] oboInOwl:hasDbXref "PMID:27647645" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025236 ; owl:annotatedTarget "Ambulation or other complex motor behaviors after getting out of bed in a sleep-like state. During sleepwalking episodes, the sonambulating individual appears confused or dazed, the eyes are usually open, and he or she might mumble or give inappropriate answers to questions, or occasionally appear agitated." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025236 ; owl:annotatedTarget "Sleep walking" . [] oboInOwl:hasDbXref "PMID:27647645" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025237 ; owl:annotatedTarget "A nocturnal episode characterized by disorientation, grogginess, and, at times, substantial agitation upon awakening from slow-wave sleep or following forced awakenings. These characteristics might present as agitation, crying or moaning, disorientation, and particularly slow mentation on arousal from sleep (i.e., sleep inertia). The duration of episodes is typically 5 to 15 min but they might last up to several hours." . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37631 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[a1211h-1b_1-5]/1/" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025238 ; owl:annotatedTarget "Foot pain" . [] oboInOwl:hasDbXref "PMID:27090882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025239 ; owl:annotatedTarget "A localized detachment of the vitreous from the retina due to the accumulation of blood. When localized in the macular area, it results in sudden profound loss of vision. Subhyaloid premacular hemorrhage is typically characterized by a circumscribed, round or dumb-bell shaped, bright red mound of blood beneath the internal limiting membrane (ILM) or between the ILM and hyaloid face, in or near to the central macular area." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025239 ; owl:annotatedTarget "Subhyaloid haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025240 ; owl:annotatedTarget "An accumulation of blood between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025240 ; owl:annotatedTarget "Preretinal haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025241 ; owl:annotatedTarget "Flame-shaped retinal haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025242 ; owl:annotatedTarget "Dot-and-blot retinal haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025243 ; owl:annotatedTarget "Subretinal haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025244 ; owl:annotatedTarget "Subretinal pigment epithelium haemorrhage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025250 ; owl:annotatedTarget "Whitehead" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37661 ; owl:annotatedTarget "glucopyranose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025251 ; owl:annotatedTarget "Blackhead" . [] oboInOwl:hasDbXref "PMID:32119353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025252 ; owl:annotatedTarget "An anomaly of the tongue characterized by loss (atrophy) of filiform papillae of the tongue, leaving areas of erythema (redness), surrounded by a serpiginous, white, hyperkeratotic border. The name geographic tongue refers to an appearance that is said to be similar to a map." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025258 ; owl:annotatedTarget "Neck stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025258 ; owl:annotatedTarget "Stiff neck" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025259 ; owl:annotatedTarget "Elbow stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025259 ; owl:annotatedTarget "Stiff elbow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025260 ; owl:annotatedTarget "Stiff wrist" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025260 ; owl:annotatedTarget "Wrist stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025261 ; owl:annotatedTarget "Finger stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025261 ; owl:annotatedTarget "Stiff finger" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025262 ; owl:annotatedTarget "Hip stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025262 ; owl:annotatedTarget "Stiff hip" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025263 ; owl:annotatedTarget "Knee stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025263 ; owl:annotatedTarget "Stiff knee" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025264 ; owl:annotatedTarget "Ankle stiffness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025264 ; owl:annotatedTarget "Stiff ankle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025265 ; owl:annotatedTarget "Stiff toe" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025265 ; owl:annotatedTarget "Toe stiffness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025268 ; owl:annotatedTarget "Stammering" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025268 ; owl:annotatedTarget "Stuttering" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37684 ; owl:annotatedTarget "PMID:16180318" . [] oboInOwl:hasDbXref "PMID:28613692" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025269 ; owl:annotatedTarget "A sudden episode of intense fear in a situation in which there is no danger or apparent cause." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025269 ; owl:annotatedTarget "Panic attack" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025270 ; owl:annotatedTarget "Abnormality of oesophagus physiology" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37684 ; owl:annotatedTarget "PMID:24407290" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025270 ; owl:annotatedTarget "Functional abnormality of the oesophagus" . [] oboInOwl:hasDbXref "PMID:22798976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025277 ; owl:annotatedTarget "Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025289 ; owl:annotatedTarget "Swollen lymph nodes in the neck" . [] oboInOwl:hasDbXref "PMID:17061271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025293 ; owl:annotatedTarget "Applies to an abnormality whose localization corresponds to the lines of Blaschko, which correspond to the lineage of epithelia cells. Blaschko lines are normally invisible but may become apparent with certain skin diseases and then can be seen to be distributed in lines horizontal to the body." . [] oboInOwl:hasDbXref "PMID:19772560" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025294 ; owl:annotatedTarget "Applies to an abnormality whose localization corresponds to the dermatomes, i.e., the nerve root distribution." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025303 ; owl:annotatedTarget "Now and then" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025309 ; owl:annotatedTarget "Irregular pupil" . [] oboInOwl:hasDbXref "PMID:27895936" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025319 ; owl:annotatedTarget "Formation of new blood vessels on the iris. The new vessels do not display the typical radially symmertic growth pattern of normal iris blood vessels, but rather appear disorganized. Rubeosis usually starts from the pupillary border with tiny tufts of dilated capillaries or red spots that can only be appreciated with high magnification." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37684 ; owl:annotatedTarget "manno-hexose" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37684 ; owl:annotatedTarget "mannose" . [] oboInOwl:hasDbXref "PMID:19254392", "PMID:2117353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025327 ; owl:annotatedTarget "Reduced dimension of the solid part of the kidney (parenchyma, the renal cortex and medulla) as measured from the collecting system (renal calyces and pelvis) to the border of the kidney. This measurement can be performed by measuring the thickness of the parenchyma in computed tomography scans." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025328 ; owl:annotatedTarget "Antepartum haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025328 ; owl:annotatedTarget "Prepartum haemorrhage" . [] oboInOwl:hasDbXref "PMID:27356651" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025329 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against glutamic acid decarboxylase." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37684 ; owl:annotatedTarget "Man" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025329 ; owl:annotatedTarget "Anti-GAD antibody positivity" . [] oboInOwl:hasDbXref "PMID:8913186" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025330 ; owl:annotatedTarget "A limitation of the ability to direct one's gaze below the horizontal meridian." . [] oboInOwl:hasDbXref "PMID:24055421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025333 ; owl:annotatedTarget "A reduction in the thickness of the outer shell (cortex) of foot bones." . [] oboInOwl:hasDbXref "PMID:23321410", "PMID:27354457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025335 ; owl:annotatedTarget "A failure to achieve the ability to stand up at an appropriate developmental stage. Most children begin to walk alone at 11 to 15 months of age. On average, children can stand while holding on at the age of 9 to 10 months, can pull up to stand and walk with one hand being held at 12 months, and can stand alone and walk well at 18 months." . [] oboInOwl:hasDbXref "PMID:23321410", "PMID:27354457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025336 ; owl:annotatedTarget "A failure to achieve the ability to sit at an appropriate developmental stage. Most children sit with support at 6 months of age and sit steadily without support at 9 months of age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025337 ; owl:annotatedTarget "Red eye" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025337 ; owl:annotatedTarget "Red eyes" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025338 ; owl:annotatedTarget "Circumlimbal hyperaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025339 ; owl:annotatedTarget "Superficial episcleral hypaeremia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025340 ; owl:annotatedTarget "Deep episcleral hyperaemia" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37786 ; owl:annotatedTarget "acyclic phosphorus acid anhydrides" . [] oboInOwl:hasDbXref "PMID:23470793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025342 ; owl:annotatedTarget "Blockage of the main artery in the retina. The typical presentation is one of profound monocular visual loss." . [] oboInOwl:hasDbXref "PMID:27331311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025343 ; owl:annotatedTarget "Presence of lupus anticoagulant (LA) autoantibodies. LA represent a heterogeneous group of autoantibodies, IgG, IgM, or a mixture of both classes, that interfere with standard phospholipid-based coagulant tests (this is only an in vitro phenomenon, LA do not cause reduction of coagulation in vivo). The antibodies are directed against plasma proteins which also bind to phospholipid surfaces." . [] oboInOwl:hasDbXref "PMID:16177252" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025344 ; owl:annotatedTarget "Damage to and obliteration of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts)." . [] oboInOwl:hasDbXref "PMID:16166103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025345 ; owl:annotatedTarget "A deviation from the normal concentration of beta-2-microglobulin in the blood." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025345 ; owl:annotatedTarget "Abnormality of circulating B2M level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025345 ; owl:annotatedTarget "Abnormality of circulating beta2-m level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025345 ; owl:annotatedTarget "Abnormality of circulating beta2m level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37793 ; owl:annotatedTarget "amino sulfonic acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37793 ; owl:annotatedTarget "aminosulfonic acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025349 ; owl:annotatedTarget "Limbal oedema" . [] oboInOwl:hasDbXref "PMID:26278858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025350 ; owl:annotatedTarget "Conjunctival papillae with a diameter greater than 1 millimeter. They characteristically have flattened tops which sometimes demonstrate staining with fluorescein." . [] oboInOwl:hasDbXref "PMID:22805709" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025352 ; owl:annotatedTarget "Description of conditions that are exclusively or predominantly observed to display de novo variants. In some cases, this may be due to the limited reproductive fitness of affected individuals." . [] oboInOwl:hasDbXref "PMID:11882049", "PMID:12848948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025353 ; owl:annotatedTarget "A type of antinuclear antibody (ANA) positivity revealed by indirect immunofluorescence (IFL). The multiple nuclear dots (MND) pattern is immunomorphologically characterized by the staining of 3-20 dots of variable size distributed all over the cell nucleus, but sparing the nucleoli, and, in contrast to the anticentromere pattern, MND reactivity does not stain the chromosomes in mitotic cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025353 ; owl:annotatedTarget "Anti-MND antibodies" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37793 ; owl:annotatedTarget "aminosulfonic acids" . [] oboInOwl:hasDbXref "PMID:19002724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025360 ; owl:annotatedTarget "Increased number of calices of the kidney." . [] oboInOwl:hasDbXref "PMID:16293636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025362 ; owl:annotatedTarget "Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla." . [] oboInOwl:hasDbXref "PMID:19571790", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025363 ; owl:annotatedTarget "Hypercellularity due to increased number of cells within glomerular capillary lumina, causing narrowing of the lumina." . [] oboInOwl:hasDbXref "NCIT:C121601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025372 ; owl:annotatedTarget "Particularly loud snoring, snoring at high volume." . [] oboInOwl:hasDbXref "PMID:15961864", "PMID:25012363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025373 ; owl:annotatedTarget "Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge." . [] oboInOwl:hasDbXref "PMID:11283793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025376 ; owl:annotatedTarget "An increased concentration of glutamine in the urine." . [] oboInOwl:hasDbXref , "PMID:33144894", "PMID:33796145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025379 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025379 ; owl:annotatedTarget "Anti-TPO antibody positivity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025379 ; owl:annotatedTarget "TPOAbs" . [] oboInOwl:hasDbXref "PMID:17341554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025381 ; owl:annotatedTarget "Circulating antipituitary antibodies (APA) are markers of autoimmune hypophysitis, which may cause deficient pituitary function." . [] oboInOwl:hasDbXref "PMID:25949488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025382 ; owl:annotatedTarget "Reduced fluid intake (drinking) in a clinical situation where the plasma molarity or sodium concentration normally would induce greater fluid intake." . [] oboInOwl:hasDbXref "PMID:22301856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025383 ; owl:annotatedTarget "An area of fat accumulation at the back of the neck in the form of a hump." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025383 ; owl:annotatedTarget "Buffalo hump" . [] oboInOwl:hasDbXref "PMID:22301856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025384 ; owl:annotatedTarget "Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025389 ; owl:annotatedTarget "High-resolution computed tomography (HRCT) can distinguish findings that characterize characterise interstitial lung diseases in a way not possible with other modalities." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025389 ; owl:annotatedTarget "Pulmonary interstitiatial HRCT abnormality" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "Beilstein:969129" . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025390 ; owl:annotatedTarget "On pulmonary high-resolution computed tomography, reticular pattern is characterised by innumerable interlacing shadows suggesting a mesh." . [] oboInOwl:hasDbXref "PMID:18195376", "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025391 ; owl:annotatedTarget "The so-called crazy paving pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025392 ; owl:annotatedTarget "A nodular pattern is characterised on pulmonary high-resolution computed tomography by the presence of numerous rounded opacities that range from 2 mm to 1 cm in diameter, with micronodules defined as smaller than 3 mm in diameter." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025393 ; owl:annotatedTarget "Co-occurrence of reticular and micronodular patterns on pulmonary high-resolution computed tomography." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025394 ; owl:annotatedTarget "On pulmonary high-resolution computed tomography, the cystic pattern is composed by well-defined, round and circumscribed air-containing parenchymal spaces with a well-defined wall and interface with normal lung. The wall of the cysts may be uniform or varied in thickness, but usually is thin (less than 2 mm) and occurs without associated emphysema." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025395 ; owl:annotatedTarget "Co-occurrence of the cystic pattern and the ground-glass pattern on pulmonary high-resolution computed tomography," . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025396 ; owl:annotatedTarget "Areas of low density corresponding to parenchymal destruction and reduced perfusion, and attenuation of the pulmonary vasculature, as visualized on pulmonary high-resolution computed tomography." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025397 ; owl:annotatedTarget "A patchwork of intermingled areas of increased and decreased attenuation visualized on pulmonary high-resolution computed tomography." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025398 ; owl:annotatedTarget "A nodular pattern on pulmonary high-resolution computed tomography that has a perilymphatic distribution." . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025399 ; owl:annotatedTarget "A nodular pattern on pulmonary high-resolution computed tomography that displays a tree-in-bud pattern, representing centrilobular branching structures that resemble a budding tree." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "CAS:106-97-8" . [] oboInOwl:hasDbXref "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025400 ; owl:annotatedTarget "A nodular pattern on pulmonary high-resolution computed tomography that has an apparently random pattern." . [] oboInOwl:hasDbXref "PMID:22675666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025401 ; owl:annotatedTarget "An abnormality in which the eyes are held permanently wide open." . [] oboInOwl:hasDbXref "PMID:6443573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025402 ; owl:annotatedTarget "Square wave jerks are saccadic eye movements which, when recorded with open eyes are considered to be a pathological sign, caused by fixation instability, and pointing to a central neurological lesion." . [] oboInOwl:hasDbXref "PMID:28242738" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025405 ; owl:annotatedTarget "A deficit in the ability to fixate eye movements in order to stabilize images on the retina" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025406 ; owl:annotatedTarget "Lack of energy and strength" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025406 ; owl:annotatedTarget "Weakness" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "CAS:106-97-8" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "Gmelin:1148" . [] oboInOwl:hasDbXref "PMID:24137272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025410 ; owl:annotatedTarget "Joining of the spleen and a gonad during embryological development." . [] oboInOwl:hasDbXref "PMID:22022062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025413 ; owl:annotatedTarget "A type of urethral stricture affecting the fossa navicularis, which is the spongy part of the male urethra located at the glans penis." . [] oboInOwl:hasDbXref "PMID:22022062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025414 ; owl:annotatedTarget "A type of urethral stricture affecting the pendulous urethra, which is straight and fixed to the corpora cavernosa." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "PMID:24179026" . [] oboInOwl:hasDbXref "PMID:26558184", "PMID:27091021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025418 ; owl:annotatedTarget "Patchy or diffuse ischemic destruction of all the elements of renal cortex resulting from significantly diminished renal arterial perfusion. Coagulative necrosis may be present, involving all tubular segments and glomeruli. Nuclei may be pale and pyknotic, or may no longer be apparent. Thrombi may be present in vessels at the edge of the infarct." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025419 ; owl:annotatedTarget "A pneumatocele is a thin walled, gas-filled space in the lung. It is most frequently caused by acute pneumonia, trauma, or aspiration of hydrocarbon fluid and is usually transient. The mechanism is believed to be a combination of parenchymal necrosis and check-valve airway obstruction. A pneumatocele appears as an approximately round, thin-walled airspace in the lung." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025419 ; owl:annotatedTarget "Pulmonary pneumatocoele" . [] oboInOwl:hasDbXref "PMID:23678356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025420 ; owl:annotatedTarget "A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025420 ; owl:annotatedTarget "Diffuse alveolar haemorrhage" . [] oboInOwl:hasDbXref "PMID:28217437" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025421 ; owl:annotatedTarget "The presence of free air in the mediastinum." . [] oboInOwl:hasDbXref "PMID:12162234", "PMID:18493546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025422 ; owl:annotatedTarget "A closed sac-like structure originating from the pleura that contains a liquid, gaseous, or semisolid substance." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "Reaxys:969129" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "butane" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "butane" . [] oboInOwl:hasDbXref "PMID:25172171" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025433 ; owl:annotatedTarget "Reduced level of the enzyme lecithin cholesterol acyl transferase." . [] oboInOwl:hasDbXref "PMID:20351687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025434 ; owl:annotatedTarget "A diminished activity of the classical complement pathway as measured by the assay for 50% haemolytic complement (CH50) activity of serum." . [] oboInOwl:hasDbXref "PMID:16500351" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025437 ; owl:annotatedTarget "Increased size of the head of sperm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "E 943a" . [] oboInOwl:hasDbXref "PMID:15491963" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025440 ; owl:annotatedTarget "Warm reactive autoantibodies are RBC-directed immune responses that are maximally reactive at 37 degrees C." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "E-943a" . [] oboInOwl:hasDbXref "PMID:9034636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025445 ; owl:annotatedTarget "Any structural anomaly of the papillary muscles of the left ventricle." . [] oboInOwl:hasDbXref "PMID:1884449" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025446 ; owl:annotatedTarget "A congenital malformation in which one or both of the papillary muscles (posteromedial or anterolateral) insert directly (that is, without interpositioned chordae tendineae) into the anterior mitral leaflet." . [] oboInOwl:hasDbXref "PMID:7850958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025448 ; owl:annotatedTarget "Abnormally anterior location of the papillary muscles of the left ventricle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "E943a" . [] oboInOwl:hasDbXref "PMID:19956703" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025451 ; owl:annotatedTarget "Testicular adrenal rest tumor (TART) is a abenign tumor of the testis. TART generally occurs multiply and bilaterally within the rete testis. Histologically, TART resemble adrenocortical tissue, which led to the name. The tumous are not encapsulated and consist of sheets or confluent cords of large polygonal cells with abundant eosinophilic cytoplasm." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025451 ; owl:annotatedTarget "Testicular adrenal rest tumour" . [] oboInOwl:hasDbXref "PMID:16858047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025452 ; owl:annotatedTarget "A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer." . [] oboInOwl:hasDbXref "PMID:10414639" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025453 ; owl:annotatedTarget "Occurence of adrenarche at a later than normal age. Adrenarche normally occurs between six and eight years of age with increased adrenal androgen secretion; its exact biologic role is not well understood. It is accompanied by changes in pilosebaceous units, a transient growth spurt and the appearance of axillary and pubic hair in some children, but no sexual development." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "N-BUTANE" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025454 ; owl:annotatedTarget "Abnormal CSF metabolite level" . [] oboInOwl:hasDbXref , "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025455 ; owl:annotatedTarget "5-HIAA (5-hydroxyindolacetic acid) concentration in the cerebrospinal fluid (CSF) is below the lower limit of normal." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025455 ; owl:annotatedTarget "Decreased CSF 5-HIAA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "R-600" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025455 ; owl:annotatedTarget "Low CSF 5-HIAA" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "n-Butan" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "n-C4H10" . [] oboInOwl:hasDbXref , "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025457 ; owl:annotatedTarget "CSF total protein level is below the lower limit of normal." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025457 ; owl:annotatedTarget "Low CSF total protein" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37808 ; owl:annotatedTarget "n-butane" . [] oboInOwl:hasDbXref , "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025458 ; owl:annotatedTarget "CSF albumin level is below the lower limit of normal." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025458 ; owl:annotatedTarget "Low CSF albumin" . [] oboInOwl:hasDbXref , "PMID:20951217" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025460 ; owl:annotatedTarget "An elevated level of myoinositol in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37826 ; owl:annotatedTarget "sulfuric acid derivative" . [] oboInOwl:hasDbXref "PMID:26950655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025464 ; owl:annotatedTarget "An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025464 ; owl:annotatedTarget "Increased ROS production" . [] oboInOwl:hasDbXref "PMID:28332382" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025469 ; owl:annotatedTarget "An abnormal loss of anagen (growth phase) hairs." . [] oboInOwl:hasDbXref "PMID:26822169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025471 ; owl:annotatedTarget "A hamartomatous proliferation containing malformed hair follicles in various stages of development. Panfolliculomas are well-circumscribed lesions demonstrating all stages of follicular differentiation." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "Beilstein:1699442" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37826 ; owl:annotatedTarget "sulfuric acid derivatives" . [] oboInOwl:hasDbXref "PMID:23074623" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025478 ; owl:annotatedTarget "Atrial standstill or silent atrium is a rare condition presenting with the absence of electrical and mechanical activity in the atria. It presents with the absence of P waves, bradycardia, and wide QRS complex in the electrocardiogram." . [] oboInOwl:hasDbXref "PMID:24369074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025479 ; owl:annotatedTarget "Neglecting one's own needs and well-being." . [] oboInOwl:hasDbXref "PMID:25394566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025482 ; owl:annotatedTarget "An abnormal result of the perchlorate discharge test. In this test, first radioactive iodine is administered, sufficient time is allowed to pass so that the radioactive iodine is captured by the thyroid,and then, perchlorate is administered orally. The perchlorate displaces non-organified iodide from the thyroid. The perchlorate discharge test is considered positive (abnormal) if there is an abnormally rapid loss of radioactive iodine from the thyroid." . [] oboInOwl:hasDbXref "PMID:9764164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025485 ; owl:annotatedTarget "Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life." . [] oboInOwl:hasDbXref "PMID:26904418" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025488 ; owl:annotatedTarget "A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37838 ; owl:annotatedTarget "carboacyl groups" . [] oboInOwl:hasDbXref "PMID:25657554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025489 ; owl:annotatedTarget "A congenital anomaly characterized by the presence of two bladders." . [] oboInOwl:hasDbXref "PMID:25999138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025490 ; owl:annotatedTarget "A congenital variant of a coronary artery in which a portion of an epicardial coronary artery (most frequently the middle segment of the left anterior descending artery) takes an intramuscular course." . [] oboInOwl:hasDbXref "PMID:25772937" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025492 ; owl:annotatedTarget "A small pupil (typically diameter less than 2 mm) that dilates poorly or not at all in response to topically administered mydriatic drugs." . [] oboInOwl:hasDbXref "PMID:25017251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025494 ; owl:annotatedTarget "Regular circumferential periaortic fibrosis involving the whole aorta and leading to a coated aorta appearance on computed tomography scans" . [] oboInOwl:hasDbXref "PMID:12368748", "PMID:24516866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025495 ; owl:annotatedTarget "Significant luminal narrowing of a long segment of the descending aorta." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_37838 ; owl:annotatedTarget "carboxylic acyl group" . [] oboInOwl:hasDbXref "PMID:19433770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025497 ; owl:annotatedTarget "A brief and sudden narrowing of a coronary artery." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025498 ; owl:annotatedTarget "Aceruloplasminaemia" . [] oboInOwl:hasDbXref "PMID:27358682", "PMID:28374180" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025503 ; owl:annotatedTarget "Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva." . [] oboInOwl:hasDbXref "PMID:25104986" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025505 ; owl:annotatedTarget "The circumflex coronary artery originates from the right aortic sinus of Valsalva." . [] oboInOwl:hasDbXref "PMID:24424336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025506 ; owl:annotatedTarget "Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva, with the additional feature that the artery passes between the two great arteries. This carries a risk of the artery being compressed by these two vessels," . [] oboInOwl:hasDbXref "PMID:28058540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025508 ; owl:annotatedTarget "Violaceous papules overlying the dorsal and lateral aspects of the metacarpophalangeal and proximal interphalangeal joints." . [] oboInOwl:hasDbXref "PMID:15686304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025512 ; owl:annotatedTarget "A papule with the same color as the surrounding skin." . [] oboInOwl:hasDbXref "PMID:24605242" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025516 ; owl:annotatedTarget "A congenital malformation with abnormal connection between one of the coronary arteries and the pulmonary artery." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025517 ; owl:annotatedTarget "Small hippocampus" . [] oboInOwl:hasDbXref "PMID:22110302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025519 ; owl:annotatedTarget "Multiple biliary hamartomas are a rare clinicopathologic entity, consisting of small (less than 1.5cm), usually multiple and nodular cystic lesions in the liver." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37838 ; owl:annotatedTarget "carboxylic acyl groups" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "phytohormone" . [] oboInOwl:hasDbXref "PMID:23304176" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025523 ; owl:annotatedTarget "A structural anomaly of the chordae tendinae of the mitral valve, whose main function is to transmit the contraction and relaxation of the papillary muscles during the cardiac cycle, thus ensuring the closing of the leaflets of the mitral valve." . [] oboInOwl:hasDbXref "PMID:21575077" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025531 ; owl:annotatedTarget "The Harlequin phenomenon consists of a sudden change in skin colour, resulting in two different body colours, one on each half of the body." . [] oboInOwl:hasDbXref "PMID:11730311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025535 ; owl:annotatedTarget "Erythematous, poikilodermatous macules distributed in a shawl pattern over the shoulders, arms and upper back." . [] oboInOwl:hasDbXref "PMID:11730311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025536 ; owl:annotatedTarget "Erythematous, poikilodermatous macules distributed in a V-shaped distribution over the anterior neck and chest." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025537 ; owl:annotatedTarget "Plantar oedema" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "phytohormones" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025538 ; owl:annotatedTarget "Palmar oedema" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025546 ; owl:annotatedTarget "Abnormal MCH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025546 ; owl:annotatedTarget "Abnormal MCHC" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025546 ; owl:annotatedTarget "Abnormal mean corpuscular Hb concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "plant growth factor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025546 ; owl:annotatedTarget "Abnormal mean corpuscular haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025546 ; owl:annotatedTarget "Abnormal mean corpuscular haemoglobin concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025547 ; owl:annotatedTarget "Decreased MCH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025547 ; owl:annotatedTarget "Decreased MCHC" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025547 ; owl:annotatedTarget "Decreased mean corpuscular Hb concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025547 ; owl:annotatedTarget "Decreased mean corpuscular haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025547 ; owl:annotatedTarget "Decreased mean corpuscular haemoglobin concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025548 ; owl:annotatedTarget "Increased MCH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025548 ; owl:annotatedTarget "Increased MCHC" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025548 ; owl:annotatedTarget "Increased mean corpuscular Hb concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "plant growth factors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025548 ; owl:annotatedTarget "Increased mean corpuscular haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025548 ; owl:annotatedTarget "Increased mean corpuscular haemoglobin concentration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025549 ; owl:annotatedTarget "A uniocular condition in which there is fixation of an object by a point other than the fovea. This point adopts the principal visual direction. The degree of the eccentric fixation is defined by its distance from the fovea in degrees." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "plant growth hormone" . [] oboInOwl:hasDbXref "PMID:20411091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025553 ; owl:annotatedTarget "Subcutaneous bleeding with a diameter greater than 1 cm (ecchymosis). The bleeding does not extend into the tarsal plate (the comparatively thick, elongated plates of dense connective tissue within the eyelid) due to an anatomic structure called the orbital septum, which limits extravasation of blood beyond the tarsal plate." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025553 ; owl:annotatedTarget "Raccoon eyes" . [] oboInOwl:hasDbXref "PMID:22223978" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025554 ; owl:annotatedTarget "A type of skin nodule (a lesions that is greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat) with a yellowish coloration (that reflects a high lipid content of the lesion)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025558 ; owl:annotatedTarget "Lamellar cataracts with associated linear lens opacities radially extending towards the periphery of the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025559 ; owl:annotatedTarget "A type of cataract characterised by club-shaped and dot opacities distributed radially in the deep cortex. These lens opacities surround the nucleus in an appearance that is though to resemble a crown." . [] oboInOwl:hasDbXref , "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025560 ; owl:annotatedTarget "Tiny deposits corresponding to cells floating in the anterior chamber of the eye. This appearance is typically associated with intraocular inflammation leading to breakdown of the blood-aqueous barrier and resulting in an increase in the number of cells and in the aqueous humor. Grading (SUN Working Group) is performed by estimating the number of cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "CAS:107-97-1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "plant growth hormones" . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025561 ; owl:annotatedTarget "Anterior chamber cells with 6-15 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025562 ; owl:annotatedTarget "Anterior chamber cells with 1-5 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025563 ; owl:annotatedTarget "Anterior chamber cells with less than one cell in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025564 ; owl:annotatedTarget "Anterior chamber cells with 16-25 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025566 ; owl:annotatedTarget "Anterior chamber cells with more than 50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." . [] oboInOwl:hasDbXref "PMID:17662099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025567 ; owl:annotatedTarget "An anomaly of the retina with serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE), and associated with blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the centre of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months." . [] oboInOwl:hasDbXref "PMID:24653824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025569 ; owl:annotatedTarget "The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization." . [] oboInOwl:hasDbXref "PMID:25709392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025570 ; owl:annotatedTarget "Increased tendency of choiroidal blood vessels to allow fluids to leak characterized by multifocal choroidal hyperfluorescence on indocyanine green angiography (ICGA)." . [] oboInOwl:hasDbXref "PMID:27190856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025571 ; owl:annotatedTarget "A type of cataract that shows a spectacular display of multiple colours that glitters with the change of incident light like an illuminated Christmas tree." . [] oboInOwl:hasDbXref "PMID:22848141" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025572 ; owl:annotatedTarget "Punctal stenosis is a condition in which the external opening of the lacrimal canaliculus is narrowed or occluded." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37848 ; owl:annotatedTarget "plant hormones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025573 ; owl:annotatedTarget "A mild form of myopia with up to -3.00 diopters." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025574 ; owl:annotatedTarget "Macular haemorrhage" . [] oboInOwl:hasDbXref "MP:0006064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025575 ; owl:annotatedTarget "Any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37886 ; owl:annotatedTarget "adrenergic agonists" . [] oboInOwl:hasDbXref "MP:0006063" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025576 ; owl:annotatedTarget "Any structural anomaly of the principal vein draining blood from the lower portion of the body." . [] oboInOwl:hasDbXref "PMID:4015927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025578 ; owl:annotatedTarget "Aortic valve prolapse can be diagnosed when either or both of the right or non-coronary aortic valve cusps (seen in the cross sectional echocardiographic long axis view) show backward bowing towards the left ventricle beyond a line joining the points of attachment of the aortic valve leaflets to the annulus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37886 ; owl:annotatedTarget "adrenergic receptor agonist" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37886 ; owl:annotatedTarget "adrenoceptor agonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025581 ; owl:annotatedTarget "Bleeding occurring within the fovea." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025581 ; owl:annotatedTarget "Foveal haemorrhage" . [] oboInOwl:hasDbXref , "PMID:23202390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025582 ; owl:annotatedTarget "Bleeding between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025582 ; owl:annotatedTarget "Sub-macular haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025582 ; owl:annotatedTarget "Submacular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025584 ; owl:annotatedTarget "A form of manifest strabismus (heterotropia) in which one eye is deviated downwards when both eyes are open." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025585 ; owl:annotatedTarget "Tendency for the visual axis of one eye to be higher than that of the other." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37886 ; owl:annotatedTarget "adrenomimetic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025586 ; owl:annotatedTarget "A type of strabismus characterized by permanent upward deviation of the visual axis of one eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025587 ; owl:annotatedTarget "A type of strabismus in which the visual axis of one eye is higher than that of the other." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025588 ; owl:annotatedTarget "A type of strabismus in which the visual axis of one eye is lower than that of the other." . [] oboInOwl:hasDbXref , "PMID:15731772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025589 ; owl:annotatedTarget "Cyclodeviation is defined as the rotation of an eyeball along the anteroposterior axis and cyclotropia as a misalignment of cyclodeviation between the two eyes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025591 ; owl:annotatedTarget "A functional anomaly of the superior oblique muscle, a fusiform muscle that originates in the upper, medial side of the orbit. The superior oblique muscle abducts, depresses and internally rotates the eye, and is the only extraocular muscle innervated by the fourth cranial nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025593 ; owl:annotatedTarget "Mechanical limitation of the range of movement of the superior oblique muscle." . [] oboInOwl:hasDbXref , "PMID:11545636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025594 ; owl:annotatedTarget "An ocular motility abnormality characterized by an overacting superior oblique muscle resulting to vertical incomitance of the eyes in lateral gaze. On examination, this is commonly seen as a downshoot of the adducting eye occuring when gaze is directed into the field of action of the inferior oblique muscle, producing a greater downward excursion of the adducted eye than of the abducted eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025595 ; owl:annotatedTarget "Reduced ocular movement of the superior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025596 ; owl:annotatedTarget "A functional anomaly of the inferior oblique muscle, an extraocular muscle that has its origin on the maxillary bone just posterior to the inferior medial orbital rim and lateral to the nasolacrimal canal and that is innervated by the inferior branch of the oculomotor nerve." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025597 ; owl:annotatedTarget "Mechanical limitation of the range of movement of the inferior oblique muscle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37886 ; owl:annotatedTarget "adrenomimetics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025598 ; owl:annotatedTarget "Decreased strength of the inferior oblique muscle." . [] oboInOwl:hasDbXref , "PMID:11545636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025599 ; owl:annotatedTarget "A common ocular motility disorder characterized by vertical incomitance of the eyes in lateral gaze. In primary inferior oblique muscle overaction, an upshoot of the adducting eye occurs when gaze is directed into the field of action of the inferior oblique muscle, producing a greater upward excursion of the adducted eye than of the abducted eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025600 ; owl:annotatedTarget "A functional anomaly of the inferior rectus muscle, which is innervated by the inferior division of oculomotor nerve and functions in the depression, adduction, and lateral rotation (extortion) of the eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025601 ; owl:annotatedTarget "Decreased strength of the inferior rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025602 ; owl:annotatedTarget "Mechanical limitation of the range of movement of the inferior rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025603 ; owl:annotatedTarget "A functional anomaly of the superior rectus muscle, an extraocular muscle that is innervated by the superior division of the oculomotor nerve, and whose primary function is the elevation of the globe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025605 ; owl:annotatedTarget "Delayed descent of the upper eyelid on downgaze. Also described by some authors as von Graefe sign." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025606 ; owl:annotatedTarget "A functional anomaly of the medial rectus muscle, an extraocular muscle that is innervated by the inferior division of the oculomotor nerve and whose sole action is the adduction of the eyeball." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025607 ; owl:annotatedTarget "An inward turning (inversion) of the margin of the upper eyelid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025608 ; owl:annotatedTarget "An outward turning (eversion) or rotation of the eyelid margin (i.e., ectropion) caused by shortening or contraction of the anterior or middle lamellae related to scarring." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37962 ; owl:annotatedTarget "adrenergic agents" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025609 ; owl:annotatedTarget "A type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025610 ; owl:annotatedTarget "A type of blepharitis that affects the meibomian glands and meibomian gland orifices. This abnormality can be associated with a spectrum of appearances ranging from meibomian seborrhoea (foaming meibomian gland secretions) and meibomianitis (inflamed meibomian glands), to chalazia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025611 ; owl:annotatedTarget "A type of epicanthus in which more extensive epicanthal folds with their origins in the eyebrow cover, pass in front of and lateral to the medial canthus (middle corner of the eye)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025612 ; owl:annotatedTarget "A type of refractive error related abnormal curvatures on the anterior or posterior surface of the cornea." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276062", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025613 ; owl:annotatedTarget "Seizures presenting with an emotion or the appearance of having an emotion as an early prominent feature, such as fear, spontaneous joy or euphoria, laughing (gelastic), or crying, (dacrystic). These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37962 ; owl:annotatedTarget "adrenergic drug" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37962 ; owl:annotatedTarget "adrenergic drugs" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "CAS:107-97-1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37962 ; owl:annotatedTarget "adrenergic neuron agents" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025623 ; owl:annotatedTarget "An abnormal proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_37962 ; owl:annotatedTarget "adrenergics" . [] oboInOwl:hasDbXref "PMID:22343568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025624 ; owl:annotatedTarget "An abnormally decreased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38077 ; owl:annotatedTarget "Beilstein:8538310" . [] oboInOwl:hasDbXref , "PMID:18772370" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025626 ; owl:annotatedTarget "An abnormally high concentration of oleic acid (oleate) in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38077 ; owl:annotatedTarget "PPys" . [] oboInOwl:hasDbXref "PMID:16969155" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025629 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against myelin-associated glycoprotein (MAG)." . [] oboInOwl:hasDbXref , "PMID:30158522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025630 ; owl:annotatedTarget "Increased amount of argininosuccinate in the urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025631 ; owl:annotatedTarget "Increased amount of alpha-aminobutyric acid in the urine." . [] oboInOwl:hasDbXref "PMID:27558335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025632 ; owl:annotatedTarget "An abnormal reduction in the amount of reactive oxygen produced by neutrophils in the respiratory burst." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38077 ; owl:annotatedTarget "poly(pyrrole)s" . [] oboInOwl:hasDbXref "NCIT:C4530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025635 ; owl:annotatedTarget "A growth protruding from the mucous membrane of the ureter. Ureteral polyps can be attached to the ureter by a broad base or a thin stalk." . [] oboInOwl:hasDbXref , "PMID:29960704" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025636 ; owl:annotatedTarget "Inflammation of the inner lining of the uterus (endometrium)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38077 ; owl:annotatedTarget "polypyrroles" . [] oboInOwl:hasDbXref , "PMID:20557770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025637 ; owl:annotatedTarget "Narrowing of an artery due to constriction of the blood vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025638 ; owl:annotatedTarget "An increased level of N-butyrylglycine in the urine." . [] oboInOwl:hasDbXref , "PMID:2002628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025641 ; owl:annotatedTarget "The concentration of glycolate in the blood circulation is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:26435653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025643 ; owl:annotatedTarget "A cerebrospinal fluid-filled nerve root cyst most often localized in the sacral spine." . [] oboInOwl:hasDbXref , "PMID:22925838", "PMID:24099056" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025644 ; owl:annotatedTarget "Fixation off sensitivity (FOS) is characterized by posterior or generalized epileptiform discharges that consistently occur with conditions that eliminate central vision, such as closed eyes, complete darkness, modified Ganzfeld stimulation (using a large white surface without visual cues), and Frenzel lenses. The FOS electroencephalogram (EEG) pattern usually consists of spikes/polyspikes and waves localized in occipital regions (bilateral or unilateral) or generalized discharges. It is usually inhibited by fixation of gaze, observing patterns, or intermittent photic stimulation (e.g., flashing light or patterns used as stimuli during the recording of the EEG)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025646 ; owl:annotatedTarget "Polymicrogyria that affects all or some of both cerebral hemispheres." . [] oboInOwl:hasDbXref , "PMID:29910038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025647 ; owl:annotatedTarget "A type of nephrotic syndrome in which complete remission (albumin urine dipstick negative/trace or proteinuria <4mg/m2/d or urinary protein to creatinine ratio <200mg/g (<20 mg/mmol) for 3 consecutive days) is achieved within initial 4 weeks of corticosteroid therapy." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025647 ; owl:annotatedTarget "SSNS" . [] oboInOwl:hasDbXref , "PMID:29910038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025648 ; owl:annotatedTarget "A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of one relapse (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response, or one to three relapses in any 12-month period." . [] oboInOwl:hasDbXref , "PMID:29910038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025649 ; owl:annotatedTarget "A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of two or more relapses (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response or four or more relapses in any 12-month period." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38101 ; owl:annotatedTarget "heterocyclic organonitrogen compounds" . [] oboInOwl:hasDbXref , "PMID:29910038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025650 ; owl:annotatedTarget "A type of nephrotic syndrome in which two consecutive relapses (albumin urine dipstick at least 3+ or proteinuria greater than 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) occur during corticosteroid therapy, or within 14 days of ceasing therapy." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025650 ; owl:annotatedTarget "SDNS" . [] oboInOwl:hasDbXref "PMID:30210239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025652 ; owl:annotatedTarget "Abnormal placental adhesion is characterized by an anomalous adherence of the placenta to the uterine wall. Based on the degree of adhesion, placental invasion can be classified into accreta, increta, or percreta." . [] oboInOwl:hasDbXref "PMID:30210239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025653 ; owl:annotatedTarget "Placenta percreta is a rare form of morbidly adherent placenta with penetration through the myometrium reaching serosa and even adjacent pelvic organs." . [] oboInOwl:hasDbXref "PMID:15145367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025654 ; owl:annotatedTarget "Abnormally firm adherence of the placenta to the uterine wall." . [] oboInOwl:hasDbXref "PMID:31167209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025656 ; owl:annotatedTarget "Sonographic detection of a double bubble sign in the upper abdomen is strongly indicative of duodenal obstruction. One bubble represents fetal stomach, and the other is attributed to a dilated proximal part of the duodenum; continuity between both bubbles is required for the sign." . [] oboInOwl:hasDbXref "PMID:20460152", "PMID:31536231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025659 ; owl:annotatedTarget "A reduction in the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood." . [] oboInOwl:hasDbXref "PMID:28613730", "PMID:32706613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025660 ; owl:annotatedTarget "A type of Chiari malformation that consists of brainstem herniation and a towering cerebellum in addition to the herniated cerebellar tonsils and vermis due to an open distal spinal dysraphism/myelomeningocele." . [] oboInOwl:hasDbXref "PMID:28613730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025661 ; owl:annotatedTarget "A type of Chiari malformation that involves herniation of the hindbrain (cerebellum with or without the brainstem) into a low occipital or high cervical meningoencephalocele." . [] oboInOwl:hasDbXref "PMID:2406168", "PMID:3292975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025663 ; owl:annotatedTarget "This ratio relates the length of the fetal femur to that of the fetal foot. The ratio is approximately 1 throughout the age range of 14 to 40 weeks of gestation. A substantial reduction in the raio can help differentiate fetuses that have dysplastic limb reduction from those whose limbs are short because of constitutional factors or IUGR. It can reduce the problem of an unknown gestational age and help to distinguish between fetal skeletal dysplasia and intrauterine growth retardation caused by other factors." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38101 ; owl:annotatedTarget "organonitrogen heterocyclic compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025664 ; owl:annotatedTarget "Birth at 32 to 36 completed weeks of gestation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025665 ; owl:annotatedTarget "Birth before 28 completed weeks of gestation (up to and including 27 weeks and 6 days of gestation)." . [] oboInOwl:hasDbXref , "PMID:27743648" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025666 ; owl:annotatedTarget "Birth before 32 completed weeks of gestation (28 up to but not including 32 weeks)." . [] oboInOwl:hasDbXref "PMID:11827888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025670 ; owl:annotatedTarget "Syntelencephaly is a rare malformation that consists of an abnormal midline connection of the cerebral hemispheres in the posterior frontal and parietal regions, with interhemispheric separation of the basal forebrain, anterior frontal lobes, and occipital regions." . [] oboInOwl:hasDbXref "PMID:16098320", "PMID:33781717" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025671 ; owl:annotatedTarget "An abnormal accumulation of fluid in which the heart is partially or completely surrounded by fluid that is seen in all views and the thickness of the fluid as observed by prenatal ultrasound is above age-dependent norms." . [] oboInOwl:hasDbXref "PMID:23696062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025672 ; owl:annotatedTarget "A separation of skin in one or more regions of the body or even along the entire length of body wall (to a degree greater than gestational-age related norms) related to pathologically increased fluid accumulation in the subcutaneous tissue." . [] oboInOwl:hasDbXref "PMID:14981382", "PMID:28567101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025673 ; owl:annotatedTarget "A type of ascites (peritoneal fluid collection) that is divided into loculi (compartments) by septa (fibrous walls). Ascites fluid can become loculated when confined by adhesions, malignancy or infection." . [] oboInOwl:hasDbXref "PMID:19293041" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025674 ; owl:annotatedTarget "A meconium-containing cyst in the peritoneal space . Meconium pseudocysts form in the presence of meconium peritonitis, which is defined as a sterile peritonitis caused by escape of meconium from the intestinal tract into the general peritoneal cavity during the fetal or perinatal period. When the extruded meconium becomes walled off, it can form a rim-calcified mass representing the meconium pseudocyst." . [] oboInOwl:hasDbXref "PMID:34304616" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "A prenatal partial or complete closure of the ductus arteriosus (i.e., prior to delivery)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "Foetal PAD narrowing-closure" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38104 ; owl:annotatedTarget "PMID:17134300" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "Foetal PDA narrowing-closure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "Foetal arterial duct narrowing-closure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "Foetal ductus arteriosus narrowing-closure" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "Idiopathic constriction of the foetal ductus arteriosus" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025675 ; owl:annotatedTarget "PCDA" . [] oboInOwl:hasDbXref "PMID:18280793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025676 ; owl:annotatedTarget "Fetal pleural effusion is the accumulation of excess fluid in the layers of tissue (pleura) lining the lungs and wall of the chest. It may be primary, also termed hydrothorax, occurring as an isolated finding or it may be secondary, most commonly resulting from non-immune hydrops." . [] oboInOwl:hasDbXref "PMID:10472400", "PMID:28351595" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025677 ; owl:annotatedTarget "The presence of chyle (a type of lipid-rich lymph) in the pleural space (the space surrounding the lung) as observed in a fetus." . [] oboInOwl:hasDbXref "PMID:25721226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025678 ; owl:annotatedTarget "Accumulation of lymphatic fluid in the pleural space. This finding is usually observed by prenatal sonography. Once neonatal feeding is established and the lymphatic fluid contains chyle, transformation to chylothorax may be observed." . [] oboInOwl:hasDbXref "PMID:31082091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025679 ; owl:annotatedTarget "Inflammation of an intervertebral disc or disk space." . [] oboInOwl:hasDbXref "PMID:25192047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025680 ; owl:annotatedTarget "Compound muscle action potential amplitude (CMAP) facilitation denotes an increase in tendon reflexes, strength, or CMAP amplitude after 10 seconds of maximal voluntary contraction." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38104 ; owl:annotatedTarget "heterocyclic organooxygen compounds" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025680 ; owl:annotatedTarget "CMAP facilitation" . [] oboInOwl:hasDbXref , "PMID:26709688", "PMID:28279852" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025682 ; owl:annotatedTarget "A gait disturbance that is characterized by excessive ankle dorsiflexion, knee and hip flexion during the stance phase." . [] oboInOwl:hasDbXref , "PMID:27025652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025683 ; owl:annotatedTarget "Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta42, which is 42 amino acids in length, is the longer form." . [] oboInOwl:hasDbXref , "PMID:15992827", "PMID:31391004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025684 ; owl:annotatedTarget "A reduction from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025685 ; owl:annotatedTarget "An elevation above the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref , "PMID:29420472" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025686 ; owl:annotatedTarget "Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta40, which is 40 amino acids in length, is the shorter form." . [] oboInOwl:hasDbXref , "PMID:19273758" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025687 ; owl:annotatedTarget "An elevation above the normal concentration of amyloid beta 40 peptide in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref , "PMID:31391004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025688 ; owl:annotatedTarget "Any anomaly in the concentration of a cleaved APP amyloid beta protein fragment in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:33099808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025689 ; owl:annotatedTarget "Focal dilatation of the extra-abdominal portion of the umbilical vein. An extra-abdominal umbilical varix is difficult to diagnose prenatally as it can appear like a cyst on ultrasound prior to birth." . [] oboInOwl:hasDbXref "PMID:24883288", "PMID:28876490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025690 ; owl:annotatedTarget "Fetal intra-abdominal umbilical vein varix (FIUVV) is defined by the focal dilatation of the fetal umbilical vein between its entry in the abdomen and its ending in the portal system. The dilatation can be defined using one of the following criteria: a portion of intra-abdominal umbilical vein that is at least 50% wider than the non-dilated portion; a dilatation of 9 mm or more, or a dilatation greater than 2 SD above the mean value for gestational age." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "CAS:107-97-1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38104 ; owl:annotatedTarget "organooxygen heterocyclic compounds" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025690 ; owl:annotatedTarget "FIUVV" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025690 ; owl:annotatedTarget "Foetal umbilical vein dilatation" . [] oboInOwl:hasDbXref , "PMID:17327355", "PMID:29763085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025691 ; owl:annotatedTarget "Impaired fasting glucose (IFG) is indicated by a fasting plasma glucose above normal but below the diabetic range. Levels between 110 mg/dl (6.1 mmol/l) to 125 mg/dl (6.9 mmol/l) are diagnostic of IFG." . [] oboInOwl:hasDbXref "PMID:26260203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025692 ; owl:annotatedTarget "A defect of development of the brain characterized by absence of the telencephalon (embryonic structure from which the mature cerebrum develops)." . [] oboInOwl:hasDbXref "PMID:32119338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025693 ; owl:annotatedTarget "A pituitary gland adenoma that is larger than 10mm." . [] oboInOwl:hasDbXref "PMID:32119338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025694 ; owl:annotatedTarget "A pituitary adenoma that is less than 10 mm in diameter." . [] oboInOwl:hasDbXref , "PMID:34713989" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025696 ; owl:annotatedTarget "A replicate of airways from accumulated and condensed mucous and cellular material. These semisolid occlusions take the shape of the airway within they are formed, leading to obstruction of the tracheobronchial tree with consecutive respiratory insufficiency. Based on their principal composition, one can differentiate fibrin casts and mucin casts. Plastic bronchitis is the name of the condition characterized by the formation of airway casts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025697 ; owl:annotatedTarget "A type of airway casts that consist of plasma components and inflammatory cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025698 ; owl:annotatedTarget "A type of airway casts that consist of impacted mucus." . [] oboInOwl:hasDbXref "PMID:33452041" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025699 ; owl:annotatedTarget "18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (FDG-PET/CT) evaluates the glucose metabolism of the brain. FDG uptake is interpreted to represent glycolysis. This term therefore represents an abnormally increased FDG uptake (increased glucose metabolism) in the region of the brain that surrounds the Sylvian fissure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38104 ; owl:annotatedTarget "oxacycles" . [] oboInOwl:hasDbXref "PMID:34230606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025700 ; owl:annotatedTarget "A complete or near-complete lack of amniotic fluid surrounding a fetus. This finding can be observed sonographically in the third trimesters if the deepest pocket of amniotic fluid is less than or equal to 2 cm." . [] oboInOwl:hasDbXref , "PMID:19248150", "PMID:20227670", "PMID:23718767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025701 ; owl:annotatedTarget "The jugular lymphatic sacs (JLS) are a physiological and temporary part of fetal lymphatic development. They are formed from small buds of lymphatic endothelial cells arising from the internal jugular veins. By 14 weeks gestation they have developed into lymphatic nodes which drain into the systemic circulation. Visibility of JLS on ultrasound past 14 weeks of gestation implies distension and this may be associated with raised nuchal translucency." . [] oboInOwl:hasDbXref "PMID:30027296", "PMID:3111205" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025702 ; owl:annotatedTarget "A type of Schizencephaly in which there is a trans-mantle column of abnormal grey matter but no evidence of a CSF-containing cleft on MR imaging." . [] oboInOwl:hasDbXref "PMID:30027296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025703 ; owl:annotatedTarget "A type of Schizencephaly in which CSF-containing cleft is present with abutting lining lips of abnormal grey matter that are opposed to each other." . [] oboInOwl:hasDbXref "PMID:30027296" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025704 ; owl:annotatedTarget "A type of Schizencephaly in which CSF-containing cleft present with non-abutting lining lips of abnormal grey matter." . [] oboInOwl:hasDbXref "PMID:16813740" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025705 ; owl:annotatedTarget "Abnormal appearance or non-visualization (apparent absence) of the nasal bone of a fetus in first trimester sonographic screening. Assessment of the fetal nasal bone is generally performed at 11-14 weeks gestational age." . [] oboInOwl:hasDbXref "PMID:23324624", "PMID:31679594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025706 ; owl:annotatedTarget "The nasal bone is considered absent when it is not visualized on a midsagittal view of the profile. In the second trimester, a true midsagittal view of the fetal profile is obtained and magnified to fill the majority of the image space. The nasal bone appears as an echogenic linear structure below the skin edge. The optimal angle of insonation is 45 degrees to the longitudinal axis of the fetal nasal bone. If the angle of insonation is 0 or 180 degrees, the nasal bone may appear artificially absent. The presence or absence of the nasal bone may be determined at the time of the 11- to 14-week ultrasound examination and used as part of the risk assessment for aneuploidy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025706 ; owl:annotatedTarget "Absence of foetal nasal bone" . [] oboInOwl:hasDbXref "PMID:27169871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025711 ; owl:annotatedTarget "Convergence-retraction nystagmus is an irregular, jerky nystagmus in which both eyeballs rhythmically converge and retract into the orbit, particularly on attempting an upward gaze." . [] oboInOwl:hasDbXref "PMID:27683622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025712 ; owl:annotatedTarget "Persistence separation of the chorionic and amnionic membranes after the 16th week of gestation (not as a result of a procedure such as amniocentesis)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38147 ; owl:annotatedTarget "cardiotonic drugs" . [] oboInOwl:hasDbXref , "PMID:30899091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025713 ; owl:annotatedTarget "Dystrophic neurites are abnormal neuronal processes characterized microscopically by aberrant sprouting, dystrophic expansion, and accumulation of various cellular organelles and cytoskeletal/signaling proteins." . [] oboInOwl:hasDbXref , "PMID:10867785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025714 ; owl:annotatedTarget "An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions." . [] oboInOwl:hasDbXref "PMID:12768548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025715 ; owl:annotatedTarget "Abnormal waveforms the Doppler sonographic examination of bloodflow in the umbilical artery. vUmbilical arterial Doppler assessment is used in surveillance of fetal health in the third trimester." . [] oboInOwl:hasDbXref , "PMID:30718211" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025716 ; owl:annotatedTarget "Low hemoglobin/hematocrit in a fetus as evidenced by percutaneous umbilical cord sampling and Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery." . [] oboInOwl:hasDbXref "PMID:20040311" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025717 ; owl:annotatedTarget "Abnormal accumulation of autophagosomes in skeletal muscle tissue." . [] oboInOwl:hasDbXref "PMID:32989482" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025718 ; owl:annotatedTarget "An increased echo intensity of muscle tissue on sonography, defined as an increased amount of returning echoes per square area of muscle tissue. On cross-section, normal muscle appears as a relatively anechoic structure with hyperechoic speckles within the tissue representing perimysial septa, giving it a starry night appearance. The boundaries of each muscle are delineated by the presence of hyperechoic fascia. In muscle disorders, one of the hallmark findings is replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity from higher sound transitions in the muscle. This increase in echogenicity is most distinct in conditions that lead to chronic pathology, such as long-standing muscle inflammation, dystrophy, or denervation." . [] oboInOwl:hasDbXref "PMID:30129127" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025719 ; owl:annotatedTarget "Gross findings of maternal vascular malperfusion include placental hypoplasia, placental infarction, and retroplacental hemorrhage. If information is available, it is preferable to annotate using the HPO terms that corresponding to the specific abnormalities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025720 ; owl:annotatedTarget "Limited mobility of the eye to move from side to side (horizontally) within its socket." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025721 ; owl:annotatedTarget "Limited mobility of the eye to move up and down (vertically) within its socket." . [] oboInOwl:hasDbXref "PMID:10867785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025722 ; owl:annotatedTarget "A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38161 ; owl:annotatedTarget "Chelating agent" . [] oboInOwl:hasDbXref "PMID:21856041" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025724 ; owl:annotatedTarget "Vernix caseosa is a physiological, viscous biofilm that is produced by desquamated fetal skin and sebaceous glands covering the fetus at the third trimester in-utero. The substance's gross morphology in post-partum is described by the etymology, as vernix means varnish, and caseosa means cheesy-like matter. This finding refers to an abnormally thick and greasy vernix caseosa-like scale present at birth." . [] oboInOwl:hasDbXref "PMID:27070354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025725 ; owl:annotatedTarget "A type of congenital pulmonary airway malformation that is characterized by multiple large cysts or a single dominant cyst." . [] oboInOwl:hasDbXref "PMID:27070354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025726 ; owl:annotatedTarget "A type of congenital pulmonary airway malformation that is characterized by multiple evenly spaced cysts (sponge-like appearance)." . [] oboInOwl:hasDbXref "PMID:27070354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025727 ; owl:annotatedTarget "A type of congenital pulmonary airway malformation that is characterized by a bulky firm mass with an adenomatoid appearance." . [] oboInOwl:hasDbXref "PMID:12423480", "PMID:32277778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025728 ; owl:annotatedTarget "Pseudocysts that lack an epithelial lining, PVPCs are frequently observed in the caudothalamic groove or in the infero-lateral aspect of the frontal horns of the lateral ventricles, but may also be located elsewhere along the periventricular germinal matrix, as in the temporal or occipital horns." . [] oboInOwl:hasDbXref "PMID:27223167" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025729 ; owl:annotatedTarget "The term fetal vascular malperfusion (FVM) is used to describe placental pathology that is throught to result from an obstruction in fetal blood flow that could result from a number of conditions (eg, umbilical cord lesions, hypercoagulability, complications of fetal cardiac dysfunction, such as hypoxia, etc.)." . [] oboInOwl:hasDbXref "PMID:30601441" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0025730 ; owl:annotatedTarget "Foramen ovale aneurysm (FOA) or atrial septal aneurysm is abnormal redundancy of the atrial septum primum, with bulging of the septum by at least half the width of the atrial chamber, or by at least 10 mm beyond the level of the atrial septum. The abnormal protrusion of the interatrial septum results in decreased left atrial volume. On color Doppler there is reduced left ventricular inflow." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0025730 ; owl:annotatedTarget "Foetal atrial septal dilatation" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030000 ; owl:annotatedTarget "Abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz." . [] oboInOwl:hasDbXref "PMID:20590416" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030001 ; owl:annotatedTarget "A condition in which the eyelids do not close to cover the eye completely." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38161 ; owl:annotatedTarget "Metal chelator" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030001 ; owl:annotatedTarget "Eyelids stay open" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030001 ; owl:annotatedTarget "Inability to close the eyelids" . [] oboInOwl:hasDbXref "PMID:20590416" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030001 ; owl:annotatedTarget "Some common causes of lagophthalmos are Bell's palsy and other types of facial paralysis, stroke, infection, and trauma. The inability to blink and effectively close the eyes leads to corneal exposure and excessive evaporation of the tear film. The main purpose when treating lagophthalmos is to prevent exposure keratitis and reestablish eyelid function." . [] oboInOwl:hasDbXref "PMID:16671223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030002 ; owl:annotatedTarget "The inability to close the eyelids during sleep." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030002 ; owl:annotatedTarget "Eyelids stay open at night" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030002 ; owl:annotatedTarget "Inability to close the eyelids at night" . [] oboInOwl:hasDbXref "PMID:16671223" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030002 ; owl:annotatedTarget "Lagophthalmos is associated with exposure keratopathy, poor sleep, and persistent exposure-related symptoms. There are a variety of causes of lagophthalmos, grouped as proptosis/eye exposure etiologies and palpebral insufficiency etiologies." . [] oboInOwl:hasDbXref "PMID:24618488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030003 ; owl:annotatedTarget "A type of lagophthalmos that occurs in association with facial nerve palsy." . [] oboInOwl:hasDbXref "PMID:24618488" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030003 ; owl:annotatedTarget "Patients with facial nerve palsy have a characteristic facial asymmetry and drooping of the angle of mouth. The temporal and zygomatic branches of facial nerve supply the forehead and eyelid muscles. Their involvement in a disease leads to paralysis of orbicularis oculi muscle resulting in lagophthalmos and ectropion." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030004 ; owl:annotatedTarget "Eyelids stay open due to scarring" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38161 ; owl:annotatedTarget "chelating agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030004 ; owl:annotatedTarget "Inability to close the eyelids due to scarring" . [] oboInOwl:hasDbXref "PMID:24467750", "PMID:24808988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030005 ; owl:annotatedTarget "An acute phenomenon characterized by hypotension and anasarca due to the loss of plasma volume into peripheral tissues, with evidence of decreased plasma volume (hemoconcentration) and protein loss from the intravascular space (hypoalbuminemia) during acute episodes." . [] oboInOwl:hasDbXref , "PMID:21654930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030006 ; owl:annotatedTarget "Abnormality in single fiber EMG recording, a technique that allows identification of action potentials (APs) from individual muscle fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030006 ; owl:annotatedTarget "Single fibre EMG abnormality" . [] oboInOwl:hasDbXref "PMID:15961866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030007 ; owl:annotatedTarget "These are spontaneous firing action potentials stimulated by needle movement of an injured muscle fiber. There is propagation to, but not past, the needle tip. This inhibits the display of the negative deflection of the waveform." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38161 ; owl:annotatedTarget "chelators" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030008 ; owl:annotatedTarget "Absent cervix" . [] oboInOwl:hasDbXref "PMID:17490914", "PMID:20643692" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030009 ; owl:annotatedTarget "A cervix that shows a painless dilation and shortening during the second trimester of pregnancy with resultant recurrent pregnancy loss or delivery is considered incompetent" . [] oboInOwl:hasDbXref "PMID:17490914", "PMID:20643692" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030009 ; owl:annotatedTarget "One of the known risk factors for preterm birth is cervical insufficiency." . [] oboInOwl:hasDbXref "PMID:24046799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030010 ; owl:annotatedTarget "Hydrometrocolpos is an accumulation of uterine and vaginal secretions as well as menstrual blood in the uterus and vagina." . [] oboInOwl:hasDbXref "PMID:24046799" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030010 ; owl:annotatedTarget "Usually hydrometrocolpos manifests at puberty caused by an obstruction of the female genital tract.The most frequent cause of hydrometrocolpos is the presence of imperforate hymen due to failure of partial resorption of this membrane during the embryonic development." . [] oboInOwl:hasDbXref "PMID:24822139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030011 ; owl:annotatedTarget "A congenital disorder where the hymen (a membrane that surrounds or partially covers the external vaginal opening) does not have an opening and completely obstructs the vagina." . [] oboInOwl:hasDbXref "PMID:24822139" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030011 ; owl:annotatedTarget "Imperformate hymen is caused by a failure of the hymen to perforate during fetal development. It is most often diagnosed in adolescent girls when menstrual blood accumulates in the vagina and sometimes also in the uterus. It can be treated by surgical incision of the hymen." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38161 ; owl:annotatedTarget "complexon" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030012 ; owl:annotatedTarget "Abnormal female reproductive system physiology" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0030012 ; owl:annotatedTarget "Abnormal female genital system physiology" . [] oboInOwl:hasDbXref "PMID:26953829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030014 ; owl:annotatedTarget "A problem occurring during any phase of the female sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity" . [] oboInOwl:hasDbXref "PMID:16391543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030015 ; owl:annotatedTarget "The persistent of recurrent difficulty, delay in, or absence of attaining orgasm following sufficient sexual stimulation and arousal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38166 ; owl:annotatedTarget "organic heteropolycyclic compounds" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030015 ; owl:annotatedTarget "Female orgasmic disorder" . [] oboInOwl:hasDbXref "PMID:16391543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030016 ; owl:annotatedTarget "Recurrent or persistent genital pain associated with sexual intercourse." . [] oboInOwl:hasDbXref "PMID:16391543" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030016 ; owl:annotatedTarget "Dyspareunia can develop secondary to medical problems such as vestibulitis, vaginal atrophy, or vaginal infection. It can be either physiologically or psychologically based, or a combination of the two." . [] oboInOwl:hasDbXref "PMID:16391543" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030017 ; owl:annotatedTarget "Recurrent or persistent involuntary spasms of the musculature of the outer third of the vagina that interferes with vaginal penetration, and which causes personal distress." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030018 ; owl:annotatedTarget "Decreased female sex drive" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030019 ; owl:annotatedTarget "Increased female sex drive" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:1b6d89bad30b8f18" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030021 ; owl:annotatedTarget "Small protrusion within the pinna." . [] oboInOwl:hasDbXref "PMID:19152421", "eom:cffbc3de49dbb172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030022 ; owl:annotatedTarget "Cleft between the helix and the lobe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030022 ; owl:annotatedTarget "Question mark ear" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030022 ; owl:annotatedTarget "Question mark ears" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38179 ; owl:annotatedTarget "monocyclic heteroarenes" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:193d1645eb4eced8" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030023 ; owl:annotatedTarget "Small cartilaginous prominence on the posterior concha." . [] oboInOwl:hasDbXref "eom:095679c21044c851" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030024 ; owl:annotatedTarget "Variably shaped, cartilage-containing tissue anterior to the external auditory meatus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030024 ; owl:annotatedTarget "Extra cartilage in front of the ear" . [] oboInOwl:hasDbXref "PMID:19152421", "eom:1fe5d46deac24493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030025 ; owl:annotatedTarget "Small indentation in the lower part of the ascending helix, concha, or in the crus helix." . [] oboInOwl:hasDbXref "PMID:19152421", "eom:ddce48fcd9ee46f4" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030026 ; owl:annotatedTarget "Flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "Gmelin:2018" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38180 ; owl:annotatedTarget "polycyclic heteroarenes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Abnormality of cartilage of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Abnormality of the nasal cartilage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Anomaly of cartilage of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Anomaly of nasal cartilage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Deformity of cartilage of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Deformity of nasal cartilage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Malformation of cartilage of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030027 ; owl:annotatedTarget "Malformation of nasal cartilage" . [] oboInOwl:hasDbXref "PMID:19152422", "eom:73e4e8bb2eec316d" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Lack of a palpable nasal cartilage." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Absent cartilage of nose" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Absent nasal cartilage" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38263 ; owl:annotatedTarget "Beilstein:1098902" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Agenesis of cartilage of nose" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Agenesis of nasal cartilage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Failure of development of cartilage of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Failure of development of nasal cartilage" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Missing cartilage of nose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030028 ; owl:annotatedTarget "Missing nasal cartilage" . [] oboInOwl:hasDbXref "PMID:19125433", "eom:ebc67f029da3caac" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030029 ; owl:annotatedTarget "Divergence of digits along the A/P axis (in the plane of the palm)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030029 ; owl:annotatedTarget "Splayed fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030029 ; owl:annotatedTarget "Spreading of the fingers" . [] oboInOwl:hasDbXref "PMID:19125433", "eom:603438e0616f4f69" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030030 ; owl:annotatedTarget "The absence of all phalanges of a digit and the associated metacarpal /metatarsal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38263 ; owl:annotatedTarget "2-amino-3-hydroxybutanoic acid" . [] oboInOwl:hasDbXref "PMID:19125433", "eom:4d06c726e63758c5" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030031 ; owl:annotatedTarget "Significant reduction in both length and girth of the toe compared to the contralateral toe, or alternatively, compared to a typical toe size for an age-matched individual." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030031 ; owl:annotatedTarget "Small toe" . [] oboInOwl:hasDbXref "PMID:19125433", "eom:6a2c173d3d7e3219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030032 ; owl:annotatedTarget "An incomplete absence of the foot, with no bony elements distal to the tarsals, but with preservation of some or all of the tarsals." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030032 ; owl:annotatedTarget "Partial absence of foot" . [] oboInOwl:hasDbXref "PMID:19125433", "eom:5b823be1388221a1" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030033 ; owl:annotatedTarget "Significant reduction in both length and girth of the finger compared to the contralateral finger, or alternatively, compared to a typical finger size for an age-matched individual." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030033 ; owl:annotatedTarget "Small finger" . [] oboInOwl:hasDbXref , "PMID:10199473", "PMID:12089752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030034 ; owl:annotatedTarget "Presence of abnormal additional layers of the basement membrane of the glomerulus." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38264 ; owl:annotatedTarget "CAS:443-79-8" . [] oboInOwl:hasDbXref "PMID:23513084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030037 ; owl:annotatedTarget "Incomplete duplication of the ureter." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38264 ; owl:annotatedTarget "CAS:443-79-8" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38264 ; owl:annotatedTarget "PMID:10944265" . [] oboInOwl:hasDbXref "PMID:22544358" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030041 ; owl:annotatedTarget "A Schmorl's node is the herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of the adjacent vertebra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030041 ; owl:annotatedTarget "Schmorl's nodes" . [] oboInOwl:hasDbXref "PMID:22544358" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030041 ; owl:annotatedTarget "Schmorl's nodes (SN) are common findings on imaging, and although most SNs are asymptomatic, some have been shown to become painful lesions." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0030042 ; owl:annotatedTarget "Incomplete maturation of the pubic bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030043 ; owl:annotatedTarget "Partial hip dislocation" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38264 ; owl:annotatedTarget "Reaxys:1721790" . [] oboInOwl:hasDbXref "PMID:21712856", "PMID:3409932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030045 ; owl:annotatedTarget "Elongated curved (S-shaped) fibulae." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38264 ; owl:annotatedTarget "2-amino-3-methylpentanoic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030045 ; owl:annotatedTarget "S-shaped calf bone" . [] oboInOwl:hasDbXref "PMID:18691338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030046 ; owl:annotatedTarget "A reduction in the degree of glycosylation of alpha-dystroglycan in muscle tissue." . [] oboInOwl:hasDbXref "PMID:18691338" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030046 ; owl:annotatedTarget "Alpha-dystroglycan is a component of the Dystrophin Associated Protein complex (DAP) which binds to various ligands in the extracellular matrix of muscle and other tissues, including laminin-alpha2, perlecan, neurexin and agrin. Disruption of the interaction between alpha-dystroglycan and its ligands has severe consequences for muscle and brain function and structure. The pathological hallmark is reduced immunolabeling of skeletal muscle with antibodies recognizing glycosylated epitopes on alpha-dystroglycan." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38275 ; owl:annotatedTarget "pyrrolidinones" . [] oboInOwl:hasDbXref "PMID:4058748" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030048 ; owl:annotatedTarget "Colpocephaly is an anatomic finding in the brain manifested by occipital horns that are disproportionately enlarged in comparison with other parts of the lateral ventricles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:11272730" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38304 ; owl:annotatedTarget "diazolidines" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030049 ; owl:annotatedTarget "Brain abscess" . [] oboInOwl:hasDbXref "PMID:21931493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030050 ; owl:annotatedTarget "An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis." . [] oboInOwl:hasDbXref "PMID:21931493" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030050 ; owl:annotatedTarget "There are two distinct groups of patients with narcolepsy, ie, those having narcolepsy with cataplexy and those having narcolepsy without cataplexy." . [] oboInOwl:hasDbXref "PMID:24757457", "PMID:26709689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030051 ; owl:annotatedTarget "An abnormal gait pattern characterized by the failure of the heel to contact the floor at the onset of stance during gait." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030051 ; owl:annotatedTarget "Toe walking" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030051 ; owl:annotatedTarget "Walking on tiptoes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030052 ; owl:annotatedTarget "Freckles in groin region" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38316 ; owl:annotatedTarget "pyrimidinecarboxylate anions" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030053 ; owl:annotatedTarget "Stiff skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030056 ; owl:annotatedTarget "Uncombable hair" . [] oboInOwl:hasDbXref "PMID:23385875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030059 ; owl:annotatedTarget "An abnormal reduction in mitochondrial DNA content of cells." . [] oboInOwl:hasDbXref "PMID:17425791" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030062 ; owl:annotatedTarget "A benign pituitary-region neoplasm that originates from Rathke's pouch. Craniopharyngiomas are benign slow growing tumors that are located within the sellar and para sellar region of the central nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38323 ; owl:annotatedTarget "cholinergic agent" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030065 ; owl:annotatedTarget "Primitive neuroectodermal tumour" . [] oboInOwl:hasDbXref "PMID:23696924" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030069 ; owl:annotatedTarget "A form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type that originates in the brain, leptomeninges, spinal cord, or eyes and typically remains confined to the CNS." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030069 ; owl:annotatedTarget "Primary CNS lymphoma" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030070 ; owl:annotatedTarget "Central primitive neuroectodermal tumour" . [] oboInOwl:hasDbXref "PMID:17566306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030071 ; owl:annotatedTarget "A primitive neuroectodermal tumor that originates from the cells of the embryonic medullary canal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030072 ; owl:annotatedTarget "Neoplasm of the paranasal sinuses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030072 ; owl:annotatedTarget "Tumor of the paranasal sinuses" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0030072 ; owl:annotatedTarget "Tumour of the paranasal sinuses" . [] oboInOwl:hasDbXref "PMID:24415964" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030075 ; owl:annotatedTarget "Presence of abnormal cells inside a milk duct, that is, non-invasive breast cancer. Ductal carcinoma in situ is considered to be a precursor lesion to invasive breast cancer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38323 ; owl:annotatedTarget "cholinergic drugs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030082 ; owl:annotatedTarget "Abnormal drinking behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030082 ; owl:annotatedTarget "Abnormal drinking behaviour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030083 ; owl:annotatedTarget "Salt craving" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38323 ; owl:annotatedTarget "cholinomimetic" . [] oboInOwl:hasDbXref "PMID:16252026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030084 ; owl:annotatedTarget "An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030084 ; owl:annotatedTarget "Curvature of digit" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030084 ; owl:annotatedTarget "Permanent curving of the finger" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38337 ; owl:annotatedTarget "pyrimidones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38443 ; owl:annotatedTarget "1-benzopyrans" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030085 ; owl:annotatedTarget "Abnormal concentration of lactate in the cerebrospinal fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38560 ; owl:annotatedTarget "simple proteins" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38631 ; owl:annotatedTarget "aminoalkylindoles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030087 ; owl:annotatedTarget "Abnormal testosterone level" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38632 ; owl:annotatedTarget "membrane transport modulators" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030088 ; owl:annotatedTarget "Increased testosterone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030088 ; owl:annotatedTarget "High serum testosterone level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030088 ; owl:annotatedTarget "High serum testosterone levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030088 ; owl:annotatedTarget "Increased serum testosterone levels" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:11850512" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38700 ; owl:annotatedTarget "organic sodium salt" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38700 ; owl:annotatedTarget "organic sodium salts" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030089 ; owl:annotatedTarget "Abnormal muscle fibre protein expression" . [] oboInOwl:hasDbXref , "PMID:2185464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030090 ; owl:annotatedTarget "An anomalous amount of merosin in muscle fibers. Merosin is a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030090 ; owl:annotatedTarget "Abnormal muscle fibre merosin expression" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030091 ; owl:annotatedTarget "Absent muscle fibre laminin alpha 2" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030091 ; owl:annotatedTarget "Absent muscle fibre merosin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030092 ; owl:annotatedTarget "A reduced amount of merosin in muscle fibers. This feature is usually assessed by immunohistochemical examination of muscle biopsy tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030092 ; owl:annotatedTarget "Reduced muscle fibre merosin" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:9400354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030093 ; owl:annotatedTarget "A deviation from normal of the amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030093 ; owl:annotatedTarget "Abnormal muscle fibre laminin beta 1" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030094 ; owl:annotatedTarget "Reduced muscle fibre laminin beta 1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38716 ; owl:annotatedTarget "carboxylic acid dianion" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030095 ; owl:annotatedTarget "A decreased amount of collagen VI in muscle tissue. Collagen VI is a primarily associated with the extracellular matrix of skeletal muscle." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:11917091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030096 ; owl:annotatedTarget "A deviation from normal in the amount of dystrophin in muscle fiber tissue. Dystrophin is located at the muscle sarcolemma in a membrane-spanning protein complex that connects the cytoskeleton to the basal lamina." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030096 ; owl:annotatedTarget "Abnormal muscle fibre dystrophin expression" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:11917091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030097 ; owl:annotatedTarget "Lack of dystrophin in muscle tissue. Immunohistochemistry reveals absent dystrophin protein in the muscle biopsy." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030098 ; owl:annotatedTarget "A decreased amount of dystrophin in muscle fiber tissue." . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:11592034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030099 ; owl:annotatedTarget "Immunohistochemistry reveals reduced alpha dystroglycan protein in the muscle biopsy. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030099 ; owl:annotatedTarget "Reduced muscle fibre alpha dystroglycan" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030100 ; owl:annotatedTarget "Deviation from normal in the amount of alpha sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030100 ; owl:annotatedTarget "Abnormal muscle fibre alpha sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030101 ; owl:annotatedTarget "Lack of alpha sarcoglycan in muscle. Immunohistochemistry reveals absent alpha sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38716 ; owl:annotatedTarget "carboxylic acid dianions" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030101 ; owl:annotatedTarget "Absent muscle fibre alpha sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030102 ; owl:annotatedTarget "A decreased amount of alpha sarcoglycan in muscle. Immunohistochemistry reveals reduced alpha sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030102 ; owl:annotatedTarget "Reduced muscle fibre alpha sarcoglycan" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030103 ; owl:annotatedTarget "Deviation from normal in the amount of beta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030103 ; owl:annotatedTarget "Abnormal muscle fibre beta sarcoglycan" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030104 ; owl:annotatedTarget "Deviation from normal in the amount of gamma sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030104 ; owl:annotatedTarget "Abnormal muscle fibre gamma sarcoglycan" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030105 ; owl:annotatedTarget "Deviation from normal in the amount of delta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030105 ; owl:annotatedTarget "Abnormal muscle fibre delta sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030106 ; owl:annotatedTarget "Immunohistochemistry shows complete lack of beta sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38717 ; owl:annotatedTarget "carboxylic acid trianion" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030106 ; owl:annotatedTarget "Absent muscle fibre beta sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030107 ; owl:annotatedTarget "Immunohistochemistry reveals reduced beta sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030107 ; owl:annotatedTarget "Reduced muscle fibre beta sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030108 ; owl:annotatedTarget "Immunohistochemistry reveals reduced gamma sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030108 ; owl:annotatedTarget "Reduced muscle fibre gamma sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030109 ; owl:annotatedTarget "Immunohistochemistry shows complete lack of gamma sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030109 ; owl:annotatedTarget "Absent muscle fibre gamma sarcoglycan" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang", "PMID:26709803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030110 ; owl:annotatedTarget "Immunohistochemistry shows complete lack of delta sarcoglycan protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030110 ; owl:annotatedTarget "Absent muscle fibre delta sarcoglycan" . [] oboInOwl:hasDbXref "PMID:26709803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030111 ; owl:annotatedTarget "Abnormally reduced amount of delta sarcoglycan in muscle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38717 ; owl:annotatedTarget "carboxylic acid trianions" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030111 ; owl:annotatedTarget "Reduced muscle fibre delta sarcoglycan" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030112 ; owl:annotatedTarget "Abnormal muscle fibre alpha dystroglycan" . [] oboInOwl:hasDbXref , "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030113 ; owl:annotatedTarget "A deviation from normal in the expression of dysferlin in muscle tissue. Dysferlin is an ubiquitous 230-kDa transmembrane protein involved in calcium-mediated sarcolemma resealing." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030113 ; owl:annotatedTarget "Abnormal muscle fibre dysferlin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030114 ; owl:annotatedTarget "Immunohistochemistry shows complete lack of dysferlin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030114 ; owl:annotatedTarget "Absent muscle fibre dysferlin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030115 ; owl:annotatedTarget "Immunohistochemistry reveals reduced dysferlin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030115 ; owl:annotatedTarget "Reduced muscle fibre dysferlin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030116 ; owl:annotatedTarget "A deviation from normal of the amount of the inner nuclear membrane protein emerin in muscle tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030116 ; owl:annotatedTarget "Abnormal muscle fibre emerin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030117 ; owl:annotatedTarget "Immunohistochemistry shows complete lack of emerin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030117 ; owl:annotatedTarget "Absent muscle fibre emerin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030118 ; owl:annotatedTarget "Immunohistochemistry reveals reduced emerin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030118 ; owl:annotatedTarget "Reduced muscle fibre emerin" . [] oboInOwl:hasDbXref , "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030119 ; owl:annotatedTarget "A deviation from normal in the amount of calpain-3 in muscle tissue. Calpains are intracellular nonlysosomal cysteine proteases modulated by calcium ions. A typical calpain is a heterodimer composed of two distinct subunits, one large (over 80 kDa) and the other small (30 kDa). While only one gene encoding the small subunit has been demonstrated, there are many genes for the large one. CAPN3 is similar to ubiquitous Calpain 1 and 2 (m-calpain and micro-calpain), but contains specific insertion sequences (NS, IS1 and IS2). Calpains cleave target proteins to modify their properties, rather than breaking down the substrates." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030119 ; owl:annotatedTarget "Abnormal muscle fibre calpain-3" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030120 ; owl:annotatedTarget "Western blot shows complete lack of calpain-3 protein in the muscle biopsy tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030120 ; owl:annotatedTarget "Absent muscle fibre calpain-3" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030121 ; owl:annotatedTarget "Western blot reveals reduced calpain-3 protein in the muscle biopsy tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030121 ; owl:annotatedTarget "Reduced muscle fibre calpain-3" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030122 ; owl:annotatedTarget "Immunohistochemistry reveals reduced perlecan protein in the muscle biopsy. Perlecan is a basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) also known as heparan sulfate proteoglycan 2 (HSPG2)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030122 ; owl:annotatedTarget "Reduced muscle fibre perlecan" . [] oboInOwl:hasDbXref , "PMID:24843229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030123 ; owl:annotatedTarget "A deviation from the normal amount of lamin A/C in muscle tissue. The LMNA gene gives rise to at least three splicing isoforms including the two main isoforms, lamin A and lamin C. These are constitutive components of the fibrous nuclear lamina and have different roles, ranging from mechanical nuclear membrane maintenance to gene regulation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030123 ; owl:annotatedTarget "Abnormal muscle fibre lamin A/C" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UToronto_htrang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030124 ; owl:annotatedTarget "A decreased amount of lamin A/C in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030124 ; owl:annotatedTarget "Reduced muscle fibre lamin A/C" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030125 ; owl:annotatedTarget "A congenital anomaly, in which the transverse process of the last lumbar vertebra (L5) fuses to the sacrum on one side or both, or to ilium, or both." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_38794 ; owl:annotatedTarget "CAS:119-24-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030126 ; owl:annotatedTarget "An anomaly of the inner mucous membrane of the uterus." . [] oboInOwl:hasDbXref , "PMID:25221341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030127 ; owl:annotatedTarget "The growth of endometrial tissue outside the uterus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030129 ; owl:annotatedTarget "Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller", "PMID:18809794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030130 ; owl:annotatedTarget "Reduced ability of von Willebrand factor (vWF) to bind collagen. Abnormal response to collagen as manifested by reduced or lacking ability of plasma von WIllebrand Factor to bind collagen. An ELISA-based assay is typically used; the test is sensitive to loss of von Willebrand Factor high molecular weight multimers." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030131 ; owl:annotatedTarget "Deviation from the normal von Willebrand factor multimer pattern." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030132 ; owl:annotatedTarget "Absence of large von Willebrand Factor multimers on gel electrophoresis." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38794 ; owl:annotatedTarget "Pteroic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller", "PMID:11756169", "PMID:25983111" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030133 ; owl:annotatedTarget "Detection of abnormal ultra-large von Willebrand factor multimers." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030134 ; owl:annotatedTarget "Complete absence of all von Willebrand factor multimers." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030135 ; owl:annotatedTarget "Lack of intermediate von Willebrand Factor multimers on gel electrophoresis." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030136 ; owl:annotatedTarget "Abnormal response to ristocetin as manifested by increased aggregation of platelets upon addition of low-dose ristocetin to platelet-rich plasma." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030137 ; owl:annotatedTarget "Prolonged bleeding following circumcision" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030138 ; owl:annotatedTarget "An abnormally increased degree of bleeding following a superfical injury to the surface of the skin." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030138 ; owl:annotatedTarget "Excessive bleeding from superficial cuts" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030139 ; owl:annotatedTarget "An abnormal high amount of bleeding following the procedure of taking a blood sample." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:cmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030140 ; owl:annotatedTarget "Recurrent or excessive bleeding from the mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030140 ; owl:annotatedTarget "Bleeding from mouth" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:15023571" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38794 ; owl:annotatedTarget "Pteroinsaeure" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030140 ; owl:annotatedTarget "Oral cavity bleeding" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030140 ; owl:annotatedTarget "Oral cavity haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030140 ; owl:annotatedTarget "Oral cavity hemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030141 ; owl:annotatedTarget "An anomaly in the placement or shape of the hairline (trichion) on the back of the head (neck), that is, the border between skin on the back of the head that has head hair." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030141 ; owl:annotatedTarget "Abnormality of hairline at back of head" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030142 ; owl:annotatedTarget "Abnormal bowel sounds" . [] oboInOwl:hasDbXref , "PMID:22767621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030143 ; owl:annotatedTarget "Abnormally increased gurgling/rumbling sounds made by the movement of fluid and gas in the intestines." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030143 ; owl:annotatedTarget "Increased bowel sounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030144 ; owl:annotatedTarget "An decreased amount of bowel sounds." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030144 ; owl:annotatedTarget "Decreased bowel sounds" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38807 ; owl:annotatedTarget "calcium channel activator" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030145 ; owl:annotatedTarget "Complete lack of abdominal sounds as assayed by examination of the abdomen with a stethoscope." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030145 ; owl:annotatedTarget "Lack of bowel sounds" . [] oboInOwl:hasDbXref , "PMID:11157536" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030146 ; owl:annotatedTarget "A structural anomaly of the liver located predominantly in the hepatocytes as opposed to stromal cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38807 ; owl:annotatedTarget "calcium channel activators" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030147 ; owl:annotatedTarget "Tremor of the trunk in an anterior-posterior plane at 3-4 Hz." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030148 ; owl:annotatedTarget "An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030148 ; owl:annotatedTarget "Heart murmur" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030148 ; owl:annotatedTarget "Heart murmurs" . [] oboInOwl:hasDbXref "PMID:24188221" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030149 ; owl:annotatedTarget "Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38807 ; owl:annotatedTarget "calcium channel agonists" . [] oboInOwl:hasDbXref , "PMID:21994886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030151 ; owl:annotatedTarget "Inflammation of the biliary ductal system, affecting the intrahepatic or extrahepatic portions, or both." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030151 ; owl:annotatedTarget "Bile duct inflammation" . [] oboInOwl:hasDbXref , "PMID:18536057", "PMID:8268770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030153 ; owl:annotatedTarget "Cholangiocarcinoma is a primary cancer originating in the biliary epithelium i.e., the cholangiocytes, of the extrahepatic and intrahepatic biliary ducts. It is extremely invasive, develops rapidly, often metastasizes, and has a very poor prognosis. They are slow growing tumors which spread longitudinally along the bile ducts with neural, perineural and subepithelial extension." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030153 ; owl:annotatedTarget "Bile duct cancer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38808 ; owl:annotatedTarget "calcium channel modulators" . [] oboInOwl:hasDbXref , "PMID:22210542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030154 ; owl:annotatedTarget "Rupture of the wall of the gallbladder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030155 ; owl:annotatedTarget "Scrotal pain" . [] oboInOwl:hasDbXref , "PMID:7876381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030156 ; owl:annotatedTarget "The presence of free monoclonal immunoglobulin light chains in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38856 ; owl:annotatedTarget "halophenol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030157 ; owl:annotatedTarget "Kidney pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030157 ; owl:annotatedTarget "Flank pain" . [] oboInOwl:hasDbXref , "PMID:21270291", "PMID:28460993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030158 ; owl:annotatedTarget "Cervical ectropion occurs when eversion of the endocervix exposes columnar epithelium to the vaginal milieu" . [] oboInOwl:hasDbXref , "PMID:21270291" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030159 ; owl:annotatedTarget "Abnormal growth of tissue projecting from a mucous membrane of the endocervix." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030159 ; owl:annotatedTarget "Cervical tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030159 ; owl:annotatedTarget "Cervical tumour" . [] oboInOwl:hasDbXref , "PMID:21270291" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030160 ; owl:annotatedTarget "Inflammation of the uterine cervix." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030160 ; owl:annotatedTarget "Uterine cervix inflammation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38856 ; owl:annotatedTarget "halophenols" . [] oboInOwl:hasDbXref , "PMID:21115671", "PMID:9402101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030162 ; owl:annotatedTarget "Abnormally large size of glomeruli." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "anaesthetic" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030163 ; owl:annotatedTarget "Abnormality of vascular function." . [] oboInOwl:hasDbXref , "PMID:12972467" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030164 ; owl:annotatedTarget "Pain in the jaw or ear induced by chewing or otherwise moving the jaw." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030164 ; owl:annotatedTarget "Jaw pain while chewing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030165 ; owl:annotatedTarget "The presence of an increased number of twists and turns of the temporal artery." . [] oboInOwl:hasDbXref , "PMID:23136329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030166 ; owl:annotatedTarget "Occurrence of excessive sweating during sleep." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030166 ; owl:annotatedTarget "Night sweats" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030167 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against mitochondria." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "Anaesthetika" . [] oboInOwl:hasDbXref "PMID:5897968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030168 ; owl:annotatedTarget "Increase in diameter of the veins located underneath the skin of the abdomen." . [] oboInOwl:hasDbXref , "PMID:24891929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030169 ; owl:annotatedTarget "Extreme dilation of the submucusoal veins in the stomach." . [] oboInOwl:hasDbXref , "PMID:24394852" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030170 ; owl:annotatedTarget "Presence of a pseudoaneurysm in the artery that supplies the gallbladder and cystic duct with blood. A pseudoaneurysm, also known as a false aneurysm, forms when blood leaks through a breach of the arterial wall but is contained by the adventitia or surrounding perivascular soft tissue." . [] oboInOwl:hasDbXref , "PMID:17963347", "PMID:3360039" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030171 ; owl:annotatedTarget "A collection of clotted blood surrounding the kidney." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "Anaesthetikum" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jbeats", "PMID:22246888" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030172 ; owl:annotatedTarget "Congenital absence of the myelin sheath on a nerve." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:15331688" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "anaesthetics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030173 ; owl:annotatedTarget "Increased amount of peripheral myelination." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "anesthetic agent" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jbeats" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030174 ; owl:annotatedTarget "Elevated thickness of the myelin sheath of peripheral nerves, in a regular and concentric fashion." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jbeats", "PMID:10727485" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030175 ; owl:annotatedTarget "The presence of multiple sausage-shaped swellings of the myelin sheath (The Latin tomaculum means sausage)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jbaets" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030176 ; owl:annotatedTarget "Loss of myelin from peripheral nerves in a pattern that differs between right and left." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030178 ; owl:annotatedTarget "Abnormality of CNS electrophysiology" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UKB_tklockgether" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030180 ; owl:annotatedTarget "Dorsiflexion of the big toe, sometimes accompanied by fanning of the other toes, elicited by stroking along the medial side of the tibia (the normal response would be no movement of the big toe)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "anesthetic drug" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UKT_rschuele", "PMID:18637037" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030181 ; owl:annotatedTarget "Dorsal extension of the big toe, sometimes accompanied by fanning of the other toes, elicited by compressing the calf muscles (a normal response is no movement of the big toe)." . [] oboInOwl:hasDbXref , "PMID:16954982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030183 ; owl:annotatedTarget "The vestibulo-ocular reflex is responsible for the stabilization of the retinal image during movement. The visual vestibular ocular reflex (VVOR) or visual enhanced VOR, maintains ocular stability during head motion by generating compensatory eye movement opposite to head movement, and is a major component of visual vestibular interaction. This feature is an impairment of this reflex, manifested as the combined impairment of the three compensatory eye movement reflexes, namely the vestibulo-ocular reflex (VOR), smooth pursuit (SP) and optokinetic reflex (OKR)." . [] oboInOwl:hasDbXref , "PMID:21404980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030185 ; owl:annotatedTarget "An isometric tremor occurs with muscle contraction against a rigid stationary object (e.g., when making a fist)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0030185 ; owl:annotatedTarget "Dystonia tremor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030186 ; owl:annotatedTarget "Essential tremor" . [] oboInOwl:hasDbXref , "PMID:4821687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030187 ; owl:annotatedTarget "Nodding movement of the head or body." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38867 ; owl:annotatedTarget "anesthetics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030188 ; owl:annotatedTarget "Tremor classified by the affected body part." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030188 ; owl:annotatedTarget "Tremor of a body part" . [] oboInOwl:hasDbXref , "HPO_CONTRIBUTOR:UNCL_mbertoli", "PMID:17986328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030192 ; owl:annotatedTarget "A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UNCL_tevangelista", "PMID:17986328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030193 ; owl:annotatedTarget "A type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref , "PMID:17986328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030194 ; owl:annotatedTarget "A type of weakness of the muscles involved in speech that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller", "PMID:17986328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030195 ; owl:annotatedTarget "A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UNCL_mbertoli" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030196 ; owl:annotatedTarget "A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030198 ; owl:annotatedTarget "A type of weakness of a skeletal muscle of distal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030199 ; owl:annotatedTarget "A type of weakness of a skeletal muscle in the neck that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030200 ; owl:annotatedTarget "A type of weakness of a skeletal muscle of proximal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030201 ; owl:annotatedTarget "Specific drugs interfere selectively with the different cellular mechanisms involved in neuromuscular transmission (synthesis, storage, release, action and inactivation of transmitter). The response of a patient to a specific drug can therefore be useful information for the differential diagnosis." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030202 ; owl:annotatedTarget "Improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030202 ; owl:annotatedTarget "Favourable response of weakness to acetylcholine esterase inhibitors" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "CAS:9002-60-2" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030203 ; owl:annotatedTarget "Lack of improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030203 ; owl:annotatedTarget "Unfavourable response of muscle weakness to acetylcholine esterase inhibitors" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller", "PMID:21654930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030205 ; owl:annotatedTarget "The variation in the time interval between the two action potentials of the same motor unit is called jitter. This term therefore applies to increased variability in the interval between successive action potentials of the same motor unit, which is measured by electromyography (EMG)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030205 ; owl:annotatedTarget "Increased jitter at single fibre EMG" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030205 ; owl:annotatedTarget "Increased jitter at single fibre electromyography" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller", "PMID:23970984" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030206 ; owl:annotatedTarget "A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to an abnormal increase in the amplitude during the course of the investigation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:tevangelista" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030207 ; owl:annotatedTarget "Breathing movements in which the chest wall moves in on inspiration and out on expiration, in reverse of the normal movements. It may be seen in children with respiratory distress of any cause, which leads to indrawing of the intercostal spaces during inspiration. Patients with chronic airways obstruction also show indrawing of the lower ribs during inspiration, due to the distorted action of a depressed and flattened diaphragm. Crush injuries of the chest, with fractured ribs and sternum, can lead to a severe degree of paradoxical breathing." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UK_rheller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030208 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ganglioside-monosialic acid (GM1), which is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030208 ; owl:annotatedTarget "Anti-AChR antibody positivity" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UNCL_mbertoli", "PMID:7739683" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030209 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against voltage-gated calcium channels." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "CAS:9002-60-2" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030209 ; owl:annotatedTarget "Ca channel antibody positivity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030209 ; owl:annotatedTarget "Ca2+ channel antibody positivity" . [] oboInOwl:hasDbXref , "PMID:22770539", "PMID:29321424", "PMID:32830177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030210 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against muscle specific kinase (anti-MuSK Ab)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UNCL_tevangelista", "PMID:974056" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030211 ; owl:annotatedTarget "Reduced velocity and acceleration in the pupillary light response." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030212 ; owl:annotatedTarget "Collecting" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030212 ; owl:annotatedTarget "Compulsive hoarding" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030212 ; owl:annotatedTarget "Hoarding" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030213 ; owl:annotatedTarget "Lack of emotional reactivity and empathy for situations or persons, sometime also for family members." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030214 ; owl:annotatedTarget "Pathological persistent sexual disinhibiting behavior, directed at oneself or to others." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030214 ; owl:annotatedTarget "Sex addiction" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "Drug_Central:4931" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030215 ; owl:annotatedTarget "Uncontrolled episodes of crying, without apparent motivating stimuli." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030215 ; owl:annotatedTarget "Inappropriate crying" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030216 ; owl:annotatedTarget "Reduction of goal-directed behaviors linked to the impairment in frontal executive functions (planning of an action for example)." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030217 ; owl:annotatedTarget "Difficulty in performing the correct execution of limbs movements in absence of motor impairment." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo", "PMID:15077237", "PMID:25452726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030218 ; owl:annotatedTarget "Punding is a stereotypical motor behavior characterized by an intense fascination with repetitive, excessive and non-goal oriented handling, and examining of objects." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo", "PMID:24966676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030219 ; owl:annotatedTarget "A progressive loss of the ability to remember the meaning of words, faces and objects." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0030219 ; owl:annotatedTarget "Trouble remembering words" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030220 ; owl:annotatedTarget "Behavior that is not in line with social norms." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030220 ; owl:annotatedTarget "Socially inappropriate behavior" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030220 ; owl:annotatedTarget "Socially inappropriate behaviour" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "Corticotropin" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030221 ; owl:annotatedTarget "Excessive desire to eat sweet foods." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030221 ; owl:annotatedTarget "Sweet craving" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:ICM_PCaroppo" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030222 ; owl:annotatedTarget "Difficulty in recognizing objects by visual input in absence of sensorial visual impairment." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030223 ; owl:annotatedTarget "Perseveration" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030223 ; owl:annotatedTarget "Perseverative behavior" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030223 ; owl:annotatedTarget "Perseverative behaviour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030224 ; owl:annotatedTarget "A deviation from normal in the expression of desmin in muscle tissue. Desmin is an 53-kDa protein." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030224 ; owl:annotatedTarget "Abnormal muscle fibre desmin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030225 ; owl:annotatedTarget "Immunohistochemistry shows accumulation of desmin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030225 ; owl:annotatedTarget "Accumulation of muscle fibre desmin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030225 ; owl:annotatedTarget "Muscle fibre desmin-reactive inclusion bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030226 ; owl:annotatedTarget "A deviation from normal in the expression of myotilin in muscle tissue. Myotilin is a 57kDa cytoskeletal protein." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030226 ; owl:annotatedTarget "Abnormal muscle fibre myotilin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030227 ; owl:annotatedTarget "Immunohistochemistry shows accumulation of myotilin protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030227 ; owl:annotatedTarget "Accumulation of muscle fibre myotilin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030228 ; owl:annotatedTarget "A deviation from normal in the expression of valosin-containing protein in muscle tissue. Valosin-containing protein is an ubiquitously expressed multifunctional 100-kD protein that is a member of the AAA+ (ATPase associated with various activities) protein family." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030228 ; owl:annotatedTarget "Abnormal muscle fibre valosin-containing protein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030229 ; owl:annotatedTarget "Immunohistochemistry shows accumulation of valosin-containing protein in the muscle biopsy." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030229 ; owl:annotatedTarget "Accumulation of muscle fibre valosin-containing protein" . [] oboInOwl:hasDbXref , "PMID:17504518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030230 ; owl:annotatedTarget "The presence of disorganized areas called cores in the center of muscle fibers. There is a typical appearance of the biopsy on light microscopy, where the muscle cells have cores that are devoid of mitochondria and specific enzymes. Cores are typically well demarcated and centrally located, but may occasionally be multiple and of eccentric." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:16154544" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "ACTH" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030230 ; owl:annotatedTarget "Central core regions in muscle fibres" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030231 ; owl:annotatedTarget "An increased amount of glycogen in muscle tissue found specifically in lysosomes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030231 ; owl:annotatedTarget "Glycogen accumulation in muscle fibre lysosomes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030232 ; owl:annotatedTarget "Elevated glycogen content in the sarcoplasm (cytoplasm) of muscle fibers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030233 ; owl:annotatedTarget "Limitation of wrist and finger extension on asking patient to form a prayer sign. This is a result of progressive wrist and finger flexion contractures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "An increased CPK level between 4X and 50X above the upper normal level." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "Highly elevated CPK" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "Highly elevated creatine phosphokinase" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "Highly elevated serum CK" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "Highly elevated serum CPK" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "Adrenocorticotropic hormone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030234 ; owl:annotatedTarget "Highly elevated serum phosph-CK" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "An increased creatine kinase level more than 50X above the upper normal level." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "Extremely elevated CPK" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "Extremely elevated creatine phosphokinase" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "Extremely elevated phospho-CK serum level" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "Extremely elevated serum CK level" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030235 ; owl:annotatedTarget "Extremely high CPK level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030236 ; owl:annotatedTarget "Abnormalities of the overall muscle bulk based on clinical observation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030236 ; owl:annotatedTarget "Abnormality of muscle size" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030237 ; owl:annotatedTarget "Reduced strength of the musculature of the hand." . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030237 ; owl:annotatedTarget "Hand muscle weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030239 ; owl:annotatedTarget "Underdevelopment of the musculature of the upper arm, which may include the deltoid, the triceps, the biceps, and the brachioradialis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030239 ; owl:annotatedTarget "Underdeveloped upper arm muscles" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "adrenocorticotropin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030241 ; owl:annotatedTarget "Underdevelopment of the deltoid muscle." . [] oboInOwl:hasDbXref , "PMID:21960890" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030242 ; owl:annotatedTarget "Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the superior and inferior mesenteric veins." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030242 ; owl:annotatedTarget "Blood clot in portal vein" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "corticotrofina" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030243 ; owl:annotatedTarget "An obstruction in the veins of the liver caused by a blood clot (thrombosis)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030243 ; owl:annotatedTarget "Blood clot in liver vein" . [] oboInOwl:hasDbXref , "PMID:24567014" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030244 ; owl:annotatedTarget "The occurence of an elevated body temperature of the mother during pregnancy." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "corticotrophine" . [] oboInOwl:hasDbXref , "PMID:11430951", "PMID:8135133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030245 ; owl:annotatedTarget "The occurence of maternal fever during labor." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030245 ; owl:annotatedTarget "Maternal fever during labor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030245 ; owl:annotatedTarget "Maternal fever during labour" . [] oboInOwl:hasDbXref , "PMID:24917213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030246 ; owl:annotatedTarget "The occurence of fever in a mother during the first trimester of pregnancy." . [] oboInOwl:hasDbXref , "PMID:20532730" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030247 ; owl:annotatedTarget "The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030247 ; owl:annotatedTarget "Blood clot in splanchnic vein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030248 ; owl:annotatedTarget "Blood clot in mesentertic vein" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030249 ; owl:annotatedTarget "A sudden eruption (rash) of the surface of a mucous membrane of the mouth or pharynx." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030251 ; owl:annotatedTarget "Complete lack of memory B cells, that is, of mature B cell type that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030252 ; owl:annotatedTarget "Complete lack of mature B cells, that is, of B cells that have left the bone marrow." . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "corticotrophinum" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030253 ; owl:annotatedTarget "A reduced ability of a T cell population to expand by cell division following T cell activation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030254 ; owl:annotatedTarget "Small areas of bleeding (hemorrhage) under the fingernail or toenail." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030254 ; owl:annotatedTarget "Nail bed haemorrhage" . [] oboInOwl:hasDbXref "ChemIDplus" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "corticotropin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030255 ; owl:annotatedTarget "The presence of multiple polyps in the large intestine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030256 ; owl:annotatedTarget "The presence of multiple polyps in the small intestine." . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030257 ; owl:annotatedTarget "One or more brown punctate macules on the skin of the genitalia." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030257 ; owl:annotatedTarget "Freckled genitalia" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030258 ; owl:annotatedTarget "Increased genital pigmentation" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030259 ; owl:annotatedTarget "Localized or generalized decreased genital pigmentation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030259 ; owl:annotatedTarget "Decreased genital pigmentation" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030260 ; owl:annotatedTarget "Length of penis more than 2 SD below the mean for age accompanied by hypospadias." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_3892 ; owl:annotatedTarget "cortrophin" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030261 ; owl:annotatedTarget "Lack of recognizable penile structures." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030261 ; owl:annotatedTarget "Absent penis" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030262 ; owl:annotatedTarget "Penile width more than 2 standard deviations (SD) below the mean for age. Alternatively circumference of the flaccid penis more than 2 SD below the mean for age. Alternatively, apparently decreased penile width for age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030262 ; owl:annotatedTarget "Narrow penis" . [] oboInOwl:hasDbXref , "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030263 ; owl:annotatedTarget "Rotated position of the glans, with or without the penile shaft, of 30 degrees or more." . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030264 ; owl:annotatedTarget "Ventral skinfold extending from penis to scrotum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030264 ; owl:annotatedTarget "Webbed penis" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:17095900" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38958 ; owl:annotatedTarget "Indole alkaloid" . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030265 ; owl:annotatedTarget "Distance between left and right side of the flaccid penis at the attachment to the skin above the pubic symphysis more than 2 standard deviations above the mean for age." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030265 ; owl:annotatedTarget "Wide penis" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030267 ; owl:annotatedTarget "Deposition of calcium salts in the fibrous sheet that connects the radius and the ulna." . [] oboInOwl:hasDbXref , "PMID:12913845", "PMID:17451374" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030268 ; owl:annotatedTarget "Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38958 ; owl:annotatedTarget "indole alkaloids" . [] oboInOwl:hasDbXref , "PMID:18436706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030269 ; owl:annotatedTarget "An elevated level of insulin-like growth factor 1 (IGF1) in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030269 ; owl:annotatedTarget "Elevated serum IGF1" . [] oboInOwl:hasDbXref , "PMID:3348976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030270 ; owl:annotatedTarget "Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030271 ; owl:annotatedTarget "This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030273 ; owl:annotatedTarget "Decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine." . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030274 ; owl:annotatedTarget "Additional scrotum, or part of a scrotum in an abnormal location." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030274 ; owl:annotatedTarget "Extra scrotum" . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030275 ; owl:annotatedTarget "Scrotum in a position other than the usual position inferior to the base of the penis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030275 ; owl:annotatedTarget "Abnormal scrotum position" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38975 ; owl:annotatedTarget "methylbenzenes" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030277 ; owl:annotatedTarget "Abnormal morphology of a vertebral pedical." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030278 ; owl:annotatedTarget "Underdeveloped vertebral pedicle." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030279 ; owl:annotatedTarget "Underdeveloped pedicle of the fifth lumbar vertebra." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030280 ; owl:annotatedTarget "Radiolucent focal defect of a rib shaft." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030280 ; owl:annotatedTarget "Rib gap" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_38976 ; owl:annotatedTarget "alkylbenzene" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030282 ; owl:annotatedTarget "Radiolucent focal defect of the posterior portion of a rib shaft. The 'gaps' may lead to flail chest." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030283 ; owl:annotatedTarget "Only part of the septum pellucidum (a thin, triangular, vertical membrane separating the lateral ventricles of the brain) is present. This feature can be appreciated on magnetic resonance tomography or computed tomography of the brain." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030284 ; owl:annotatedTarget "A form of macrogloassia (increased size of the tongue) characterized by a broad based root of the tongue but a small tongue tip, giving the appearance of a triangle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38976 ; owl:annotatedTarget "Alkylbenzol" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030284 ; owl:annotatedTarget "Triangle shaped tongue" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030284 ; owl:annotatedTarget "Triangular tongue" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030285 ; owl:annotatedTarget "Abnormal splayed configuration (spreading out) of the superior cerebellar peduncle." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_38976 ; owl:annotatedTarget "alkylbenzenes" . ( ) . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030286 ; owl:annotatedTarget "Atrophy of the superior cerebellar peduncle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030289 ; owl:annotatedTarget "An abnormal flattening of an epiphysis of femur." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030289 ; owl:annotatedTarget "Flattended end part of thigh bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39015 ; owl:annotatedTarget "apolipoproteins" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "inclusion compound" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0030290 ; owl:annotatedTarget _:genid89164 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030290 ; owl:annotatedTarget "Lack of ossification of the sacrum." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "compose d'inclusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030291 ; owl:annotatedTarget "Irregularity of the normally smooth surface of one or more metaphyses of a bone of the leg." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "compuesto de inclusion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030292 ; owl:annotatedTarget "Irregularity of the normally smooth surface of a metaphysis of a tibia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030293 ; owl:annotatedTarget "Irregularity of the normally smooth surface of a metaphysis of a fibula." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "compuestos de inclusion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030293 ; owl:annotatedTarget "Irregularity of wide portion of calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030299 ; owl:annotatedTarget "An anomaly of the metaphysis of the distal femur (close to the knee)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030299 ; owl:annotatedTarget "Abnormality of wide portion of outermost thighbone" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030300 ; owl:annotatedTarget "Presence of only 10 (instead of the usual 12) pairs of ribs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030300 ; owl:annotatedTarget "10 pairs of ribs" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "inclusion complex" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030301 ; owl:annotatedTarget "An anomaly of the anterior commissure, a bundle of nerve fibers that connect the two cerebral hemispheres across the midline. The anterior commissure plays a role in pain sensation and contains decussating fibers from the olfactory tracts." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030302 ; owl:annotatedTarget "Absence of the anterior commissure." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030303 ; owl:annotatedTarget "Underdevelopment of the anterior commissure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030304 ; owl:annotatedTarget "A deviation from the normal number of vertebrae in the spinal column." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39022 ; owl:annotatedTarget "inclusion compounds" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030306 ; owl:annotatedTarget "The presence of 11 instead of the normal 12 thoracic vertebrae." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030307 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the leg." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030307 ; owl:annotatedTarget "Flared metaphysis of lower limb bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030308 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of the distal tibia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030308 ; owl:annotatedTarget "Flared outermost metaphysis of shankbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030308 ; owl:annotatedTarget "Flared outermost metaphysis of shinbone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030309 ; owl:annotatedTarget "The presence of a splayed (i.e.,flared) metaphyseal segment of the distal fibula." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "clathrates" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030309 ; owl:annotatedTarget "Flared outermost wide portion of of calf bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030310 ; owl:annotatedTarget "Displacement or malalignment of one or more joints in the upper extremity (arm)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030310 ; owl:annotatedTarget "Dislocated arm joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030311 ; owl:annotatedTarget "Displacement or malalignment of one or more joints in the lower extremity (leg)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030311 ; owl:annotatedTarget "Dislocated leg joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030312 ; owl:annotatedTarget "Absence of the spongy bone structure (or tissue) of the internal part of the skull cap (i.e., of the calvarial diploe)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030312 ; owl:annotatedTarget "Obliteration of cranial cancellous bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "Clathrat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030313 ; owl:annotatedTarget "An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030318 ; owl:annotatedTarget "A type of inflammation of the lips involving one or both of the corners of the mouth." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030318 ; owl:annotatedTarget "Inflammation of corners of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030318 ; owl:annotatedTarget "Inflammation of oral commisures" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030318 ; owl:annotatedTarget "Red and sore corners of the mouth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "Clathratverbindung" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Decreased facial muscle strength" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Decreased strength of facial muscles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Face weakness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Facial muscle weakness" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Facial weakness" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Myasthenia of facial muscles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Reduced facial muscle strength" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Weakness of face" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030319 ; owl:annotatedTarget "Weakness of facial musculature" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "Klathrat" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030320 ; owl:annotatedTarget "An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disc space." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "Klathratverbindung" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030321 ; owl:annotatedTarget "An anomaly of the vertebral artery, the major artery of the neck that originates from the subclavian artery and merges to form the single midline basilar artery in a complex called the vertebrobasilar system." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030323 ; owl:annotatedTarget "Underdevelopment of the vertebral artery on one side." . [] oboInOwl:hasDbXref , "PMID:23816871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030324 ; owl:annotatedTarget "Underdevelopment of the vertebral artery on both sides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030325 ; owl:annotatedTarget "Fissure within the spinal cord of the neck." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "cage compound" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030326 ; owl:annotatedTarget "An anomaly in the number of macrophages." . [] oboInOwl:hasDbXref , "PMID:3513575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030328 ; owl:annotatedTarget "Decreased number of osteoclasts in bone tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030329 ; owl:annotatedTarget "Reduced anteroposterior thickness of the retina. This phenotype can be appreciated by retinal optical coherence tomography (OCT)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030329 ; owl:annotatedTarget "Retinal thinning" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030330 ; owl:annotatedTarget "The presence of cartilage cells (chondrocytes) that are substantially increased in size and contain more than one nucleus and are located within the resting zone of the epiphyseal cartilage." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:17901997" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "clathrate" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:UToronto_bgallinger", "PMID:19375384" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030331 ; owl:annotatedTarget "A reduced ability of the skin of the fingertips to wrinkle when exposed to stimuli such as soaking in water or application of EMLA cream (the fingertip remains smooth)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030334 ; owl:annotatedTarget "A structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell. These cells are regulatory T cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030335 ; owl:annotatedTarget "A deviation from the normal count of CD4-positive, CD25-positive, alpha-beta regulatory T cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "clathrate compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030336 ; owl:annotatedTarget "Lack of CD4+CD25+ T regulatory cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030337 ; owl:annotatedTarget "An increased number of CD4-positive, CD25-positive regulatory T cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "clatrato" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030338 ; owl:annotatedTarget "An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "clatratos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030339 ; owl:annotatedTarget "A reduction of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030341 ; owl:annotatedTarget "A reduction of the circulating level of follicle-stimulating hormone (FSH)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39024 ; owl:annotatedTarget "compuesto de clatrato" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030344 ; owl:annotatedTarget "A reduction in the circulating level of luteinizing hormone (LH)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:11082530" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030345 ; owl:annotatedTarget "Abnormal luteinizing hormone level" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030345 ; owl:annotatedTarget "Increased circulating lutropin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030346 ; owl:annotatedTarget "An anomaly of the circulating level of follicle-stimulating hormone (FSH)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:15583011" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030347 ; owl:annotatedTarget "An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:15913955" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:19349632" . [] oboInOwl:hasDbXref , "PMID:27491213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030348 ; owl:annotatedTarget "An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:19433577" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28401639" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030349 ; owl:annotatedTarget "A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030350 ; owl:annotatedTarget "A circumscribed, solid elevation of skin with no visible fluid that is reddish (erythematous) in color." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030352 ; owl:annotatedTarget "An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030353 ; owl:annotatedTarget "A reduced level of insulin-like growth factor 1 (IGF1) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:28487810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030354 ; owl:annotatedTarget "Abnormal levels of interferon in the blood." . [] oboInOwl:hasDbXref "PMID:11335769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030355 ; owl:annotatedTarget "Abnormal levels of interferon gamma measured in the blood circulation." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28432662" . [] oboInOwl:hasDbXref , "PMID:11335769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030356 ; owl:annotatedTarget "An elevation in the concentration of interferon gamma measured in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030357 ; owl:annotatedTarget "Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030359 ; owl:annotatedTarget "A type of non-small cell lung carcinoma that is derived from stratified squamous epithelial cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030360 ; owl:annotatedTarget "A type of non-small cell lung carcinoma that is derived from undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung, and which is differentiate from small-cell lung carcinoma by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of salt-and-pepper appearance of the chromatin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030361 ; owl:annotatedTarget "Any deviation from the normal concentration in the blood circulation of an icosanoid (also known as eicosanoids). These are signaling molecules derived from oxidation of 20-carbon fatty acids. Most are produced from arachidonic acid, a 20-carbon polyunsaturated fatty acid (5,8,11,14-eicosatetraenoic acid)." . [] oboInOwl:hasDbXref , "PMID:8174281", "PMID:8472351" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030362 ; owl:annotatedTarget "A reduction in the level of carnitine in muscle tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030363 ; owl:annotatedTarget "Delivery by Caesarian section representing the first time the mother has delivered by Caesarian section." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030364 ; owl:annotatedTarget "Delivery by Caesarian section representing where the mother has already had a previous Cesarean delivery, and this is a repeat Cesarean birth." . [] oboInOwl:hasDbXref , "PMID:24104780" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030365 ; owl:annotatedTarget "Vaginal birth after Caesarian (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally." . [] oboInOwl:hasDbXref , "PMID:23962177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030366 ; owl:annotatedTarget "The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28792690" . [] oboInOwl:hasDbXref , "PMID:25480037", "PMID:6540680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030368 ; owl:annotatedTarget "An accessory phalanx of the index (second) finger that is arranged linearly with the other phalanges. Hyperphalangy of the index finger results from an accessory ossification center at the metacarpophalangeal joint, resulting in radial deviation of the index finger. Note that this term refers only to this type of hyperphalangy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030369 ; owl:annotatedTarget "Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28827781" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030370 ; owl:annotatedTarget "A deviation in the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to the total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28847800" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030371 ; owl:annotatedTarget "An elevation above the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28859941" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "PMID:28870972" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030372 ; owl:annotatedTarget "A reduction below normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "LDL" . [] oboInOwl:hasDbXref , "PMID:15771579" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030373 ; owl:annotatedTarget "A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "beta-lipoproteins" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39026 ; owl:annotatedTarget "low-density lipoproteins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030374 ; owl:annotatedTarget "A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:19577367" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39141 ; owl:annotatedTarget "Bronsted acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030375 ; owl:annotatedTarget "An elevation in the proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39141 ; owl:annotatedTarget "Bronsted-Saeure" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030376 ; owl:annotatedTarget "A deviation from normal proportion of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39141 ; owl:annotatedTarget "acide de Bronsted" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39141 ; owl:annotatedTarget "donneur d'hydron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030377 ; owl:annotatedTarget "An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39141 ; owl:annotatedTarget "hydron donor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030378 ; owl:annotatedTarget "A reduction in normal proportion of immature B cells (CD19+/ CD21low)in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39142 ; owl:annotatedTarget "Bronsted base" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39142 ; owl:annotatedTarget "Bronsted-Base" . [] oboInOwl:hasDbXref , "PMID:23731328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030379 ; owl:annotatedTarget "A deviation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39142 ; owl:annotatedTarget "accepteur d'hydron" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030380 ; owl:annotatedTarget "A reduction in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39142 ; owl:annotatedTarget "base de Bronsted" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030381 ; owl:annotatedTarget "An elevation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39142 ; owl:annotatedTarget "hydron acceptor" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:19619564" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39144 ; owl:annotatedTarget "Lewis base" . [] oboInOwl:hasDbXref , "PMID:9802980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030383 ; owl:annotatedTarget "A deviation of the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39144 ; owl:annotatedTarget "Lewis-Base" . [] oboInOwl:hasDbXref "PMID:9802980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030384 ; owl:annotatedTarget "A reduction in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39144 ; owl:annotatedTarget "base de Lewis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39144 ; owl:annotatedTarget "donneur d'une paire d'electrons" . [] oboInOwl:hasDbXref , "PMID:9802980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030385 ; owl:annotatedTarget "An elevation in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39144 ; owl:annotatedTarget "electron donor" . [] oboInOwl:hasDbXref , "PMID:19342988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030386 ; owl:annotatedTarget "A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030387 ; owl:annotatedTarget "An increase in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "Beilstein:3537533" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030388 ; owl:annotatedTarget "A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030389 ; owl:annotatedTarget "Any deivation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels." . [] oboInOwl:hasDbXref "PMID:9820300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030390 ; owl:annotatedTarget "An abnormally decreased concentration of leukotriene C4 in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030391 ; owl:annotatedTarget "Reduced ability of lexical discrimination, which refers to the process of distinguishing a stimulus word from other phonologically similar words. Lexical discrimination can be defined as the process of correctly identifying words in the mental lexicon to match the phonological input of a stimulus." . [] oboInOwl:hasDbXref , "PMID:11135453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030392 ; owl:annotatedTarget "Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III." . [] oboInOwl:hasDbXref "PMID:24966979" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030393 ; owl:annotatedTarget "A low-grade papillary epithelial neoplasm (adenocarcinoma) with a slow growth pattern. The endolymphatic duct emerges from the posterior wall of the saccule (of the inner ear) and ends in a blind pouch, the endolymphatic sac. Endolymphatic sac tumors (ELSTs) are known under different names in the literature (Heffner tumor, aggressive papillary middle ear tumor, and low-grade adenocarcinoma of endolymphatic sac origin)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030393 ; owl:annotatedTarget "Aggressive papillary middle ear tumour" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "Gmelin:325844" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030393 ; owl:annotatedTarget "Endolymphatic sac tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030393 ; owl:annotatedTarget "Heffner tumour" . [] oboInOwl:hasDbXref , "NCIT:C3867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030394 ; owl:annotatedTarget "Carcinoma that originates in the Fallopian tube. It may be located in the wall or within the lumen as a growth attached to the wall by a stalk." . [] oboInOwl:hasDbXref , "PMID:19450911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030396 ; owl:annotatedTarget "Platelets are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules - alpha-granules, dense granules, and lysosomes - the alpha-granule is the most abundant. Granule contents must be released from their intracellular repository in order to achieve their physiologic function, and this term refers to a functional defect in granule secretion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030397 ; owl:annotatedTarget "Abnormal release of dense granules from platelets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030399 ; owl:annotatedTarget "Abnormal release of alpha granule contents from platelets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030400 ; owl:annotatedTarget "Abnormal release of lysosome contents from platelets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030401 ; owl:annotatedTarget "Deviation from normal of the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) within platelets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030402 ; owl:annotatedTarget "An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030403 ; owl:annotatedTarget "Clumping together of platelets in the blood in a platelet aggregation test without addition of agents normally used to induce aggregation." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "Reaxys:3537533" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030404 ; owl:annotatedTarget "An endocrine tumor of the pancreas that secretes excessive amounts of glucagon." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030405 ; owl:annotatedTarget "A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030405 ; owl:annotatedTarget "Pancreatic endocrine tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030406 ; owl:annotatedTarget "A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum." . [] oboInOwl:hasDbXref , "PMID:21717450" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030408 ; owl:annotatedTarget "Pineoblastoma is a rare primitive neuroectodermal tumor (PNET) arising in the pineal gland. Pineoblastomas are classified as a WHO grade IV tumor and comprise one-fourth to one-half of pineal parenchymal tumors. Pineoblastoma is a highly cellular tumor originating in the pineal gland and containing small, poorly differentiated cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030409 ; owl:annotatedTarget "A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030409 ; owl:annotatedTarget "Renal urothelial carcinoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030409 ; owl:annotatedTarget "Transitional renal cell carcinoma" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030410 ; owl:annotatedTarget "A carcinoma that arises in a sebaseous gland (an exocrine gland of the skin that secretes sebum, a waxy substance)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030411 ; owl:annotatedTarget "A malignant epithelial tumor with a glandular organization that originates in the jejunum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "PMID:19944746" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "4-oxopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030412 ; owl:annotatedTarget "A malignant epithelial tumor with a glandular organization that originates in the ileum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030413 ; owl:annotatedTarget "A carcinoma derived from a squamous epithelial cell of the tongue." . [] oboInOwl:hasDbXref , "PMID:20730609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030415 ; owl:annotatedTarget "Sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030416 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the female external genital tract (vulva)." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030416 ; owl:annotatedTarget "Tumor of the vulva" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030416 ; owl:annotatedTarget "Tumour of the vulva" . [] oboInOwl:hasDbXref , "PMID:25848321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030417 ; owl:annotatedTarget "A cancer that originates in the squamous cells that line the surface of the vulva." . [] oboInOwl:hasDbXref , "PMID:8723827" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030418 ; owl:annotatedTarget "A type of vulvar cancer that originates from melanocytes of the vulva." . [] oboInOwl:hasDbXref , "PMID:25013508" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030419 ; owl:annotatedTarget "A cancer arising in a cell of the Bartholin gland, a racemose gland located slightly posterior to the opening of the vagina." . [] oboInOwl:hasDbXref , "PMID:23761517" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030420 ; owl:annotatedTarget "An adenocarcinoma arising in the vulva." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "4-oxopentanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030421 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the epididymis, an duct that transports spermatozoa from the testis to the vas deferens." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "3-acetylpropionate" . [] oboInOwl:hasDbXref , "PMID:24794024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030423 ; owl:annotatedTarget "A closed sac located in the spleen." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030423 ; owl:annotatedTarget "Cyst on spleen" . [] oboInOwl:hasDbXref , "PMID:14767330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030424 ; owl:annotatedTarget "A smooth, extratesticular, spherical cyst in the head of the epididymis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030424 ; owl:annotatedTarget "Epididymal cysts" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030425 ; owl:annotatedTarget "A cyst of the ovary that exhibits deposition of calcium salts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030426 ; owl:annotatedTarget "A benign central bone tumor composed of fibrous connective tissue within which bone is formed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030427 ; owl:annotatedTarget "A benign central bone tumor of the jaw composed of fibrous connective tissue within which bone is formed." . [] oboInOwl:hasDbXref , "PMID:25118746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030428 ; owl:annotatedTarget "A myxoma originating in the skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "4-ketovalerate" . [] oboInOwl:hasDbXref , "PMID:15661706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030429 ; owl:annotatedTarget "A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030430 ; owl:annotatedTarget "A tumor made up of nerve cells and nerve fibers." . [] oboInOwl:hasDbXref , "http://www.apma.org/learn/foothealth.cfm?itemnumber=987" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030430 ; owl:annotatedTarget "Nerve tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030430 ; owl:annotatedTarget "Nerve tumour" . [] oboInOwl:hasDbXref , "http://www.apma.org/learn/foothealth.cfm?itemnumber=987" ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030430 ; owl:annotatedTarget "Pinched nerve" . [] oboInOwl:hasDbXref , "PMID:18271966" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030431 ; owl:annotatedTarget "A cartilage capped bony outgrowth of a long bone. Osteochondroma arises on the external surface of bone containing a marrow cavity that is continuous with that of the underlying bone." . [] oboInOwl:hasDbXref , "https://en.wikipedia.org/wiki/osteochondroma" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030431 ; owl:annotatedTarget "Osteocartilaginous exostoses" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030431 ; owl:annotatedTarget "Osteochondromas" . [] oboInOwl:hasDbXref , "PMID:19387641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030432 ; owl:annotatedTarget "A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells." . [] oboInOwl:hasDbXref , "PMID:23329939" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030433 ; owl:annotatedTarget "A bening tumor of bone composed of a central zone named nidus which is an atypical bone completely enclosed within a well vascularized stroma and a peripheral sclerotic reaction zone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "4-oxovalerate" . [] oboInOwl:hasDbXref , "PMID:21430899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030434 ; owl:annotatedTarget "Pilomatricoma is an asymptomatic slowly growing benign cutaneous tumor, differentiating towards the hair matrix of the hair follicle. It is covered by normal or hyperemic skin, and usually varies in size from 0.5 to 3 cm." . [] oboInOwl:hasDbXref , "PMID:17804924" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030436 ; owl:annotatedTarget "Fibrofolliculoma is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions in adults in different areas such as the scalp, forehead, face, and neck. According to histology, the lesion is a fibrotic hamartoma characterized by infundibular epithelial proliferation and perifollicular fibrous proliferation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030436 ; owl:annotatedTarget "Fibrofolliculomas" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030437 ; owl:annotatedTarget "Anal canal tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030437 ; owl:annotatedTarget "Anal canal tumour" . [] oboInOwl:hasDbXref , "PMID:22379406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030438 ; owl:annotatedTarget "A squamous cell carcinoma that originates in the anal canal." . [] oboInOwl:hasDbXref , "PMID:22379406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030439 ; owl:annotatedTarget "An adenoma carcinoma that originates in the anal canal." . [] oboInOwl:hasDbXref , "PMID:22379406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030440 ; owl:annotatedTarget "A tumor of the anal margin." . [] oboInOwl:hasDbXref , "PMID:22379406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030441 ; owl:annotatedTarget "An intraepithelial adenocarcinoma originating in the anal margin and characterized by presence of typical Paget's cells, appearing as large rounded vacuolated cells." . [] oboInOwl:hasDbXref , "PMID:22379406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030442 ; owl:annotatedTarget "A squamous cell carcinoma that originates in the skin of the anal margin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "beta-acetylpropionate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030443 ; owl:annotatedTarget "A basal cell carcinoma that originates in the anal margin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030444 ; owl:annotatedTarget "A melanoma that originates in the anal margin." . [] oboInOwl:hasDbXref , "PMID:21043816", "PMID:24179657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030445 ; owl:annotatedTarget "A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030445 ; owl:annotatedTarget "Lung carcinoid tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030445 ; owl:annotatedTarget "Pulmonary carcinoid tumour" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030446 ; owl:annotatedTarget "Atypical pulmonary carcinoid tumour" . [] oboInOwl:hasDbXref , "PMID:16565213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030447 ; owl:annotatedTarget "A malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. Most patients present with rapidly growing, painless, firm, non-tender, dome-shaped red, occasionally ulcerated skin nodules, which have a red or bluish color, measuring up to several centimeters, on predominantly sun-exposed areas of the body. The overlying skin is smooth and shiny, sometimes exhibiting ulcerative, acneiform or telangiectatic features." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030447 ; owl:annotatedTarget "Neuroendocrine tumour of the skin" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030448 ; owl:annotatedTarget "A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030448 ; owl:annotatedTarget "Soft tissue sarcomas" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "gamma-ketovalerate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030449 ; owl:annotatedTarget "Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "laevulinate" . [] oboInOwl:hasDbXref , "PMID:24936122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030451 ; owl:annotatedTarget "A closed fluid filled sac originating from the mesentary." . [] oboInOwl:hasDbXref , "PMID:19946589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030452 ; owl:annotatedTarget "A type of mesenteric cyst that is lined with a thin endothelium or mesothelium and filled with chylous and lymphatic fluid." . [] oboInOwl:hasDbXref "PMID:21298321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030454 ; owl:annotatedTarget "The clinical electro-oculogram (EOG) is an electrophysiological test of function of the outer retina and retinal pigment epithelium (RPE) in which changes in electrical potential across the RPE are recorded during successive periods of dark and light adaptation." . [] oboInOwl:hasDbXref "PMID:25502644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030465 ; owl:annotatedTarget "No detectable response to the light-adapted 3.0 ERG (single-flash cone response). This type of ERG measures responses of the cone system; a-waves arise from cone photoreceptors and cone off-bipolar cells; the b-wave comes from On- and Off-cone bipolar cells." . [] oboInOwl:hasDbXref , "PMID:17522779", "PMID:3076152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030467 ; owl:annotatedTarget "An anomalous response to a pattern electroretinogram (PERG), a particular kind of ERG obtained in response to contrast modulation of patterned visual stimuli at constant mean luminance-typically contrast-reversing gratings or checkerboards-whose characteristics are fundamentally different from those of the traditional ERG in response to diffuse flashes of light." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030473 ; owl:annotatedTarget "Abnormal light-adapted 30Hz flicker ERG" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030473 ; owl:annotatedTarget "Abnormal light-adapted flicker ERG" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030491 ; owl:annotatedTarget "Atrophy of the capillary lamina of choroid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "levulate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39150 ; owl:annotatedTarget "levulinate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030496 ; owl:annotatedTarget "Yellow-white intraretinal deposits in the macula typically associated with damaged outer blood-retina barrier and exudation of serous fluid and lipids from the retinal microvasculature." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030496 ; owl:annotatedTarget "Macular exudates" . [] oboInOwl:hasDbXref "PMID:6169833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030497 ; owl:annotatedTarget "Fluffy white patch on the macula, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030498 ; owl:annotatedTarget "Abnormal increase in retinal thickness in the macular area observed on fundoscopy or fundus imaging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030499 ; owl:annotatedTarget "Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye. This class refers to the presence of Drusen in the macula." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030502 ; owl:annotatedTarget "Splitting of the neuroretinal layers of the retina." . [] oboInOwl:hasDbXref "PMID:21763485" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030505 ; owl:annotatedTarget "Clumped pigmentary changes of nummular appearance (i.e., thought to resemble the shape of a coin or multiple coins stuck together) at the level of the retinal pigment epithelium." . [] oboInOwl:hasDbXref "PMID:12498506" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030507 ; owl:annotatedTarget "Crystalline deposits in the retina." . [] oboInOwl:hasDbXref "PMID:25770143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030511 ; owl:annotatedTarget "Difficulty in seeing moving objects." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "Reaxys:1699442" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39317 ; owl:annotatedTarget "growth regulators" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030511 ; owl:annotatedTarget "Difficulty seeing moving objects" . [] oboInOwl:hasDbXref , "PMID:28779882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030515 ; owl:annotatedTarget "Moderate reduction of the ability to see defined as visual acuity less than 6/18 (20/60 in US notation; 0.5 in decimal notation) but at least 6/60 (20/200 in US notation; 0.1 in decimal notation)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030515 ; owl:annotatedTarget "Moderate visual impairment" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030522 ; owl:annotatedTarget "A diminution of the peripheral visual field whereby at least 50 degrees of central field are preserved in all meridians." . [] oboInOwl:hasDbXref "PMID:30581310" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030529 ; owl:annotatedTarget "An annular field defect centered on fixation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030530 ; owl:annotatedTarget "Arc-shaped blind spot" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030584 ; owl:annotatedTarget "Colour vision test abnormality" . [] oboInOwl:hasDbXref "PMID:5694282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030599 ; owl:annotatedTarget "The Esterman grid test assays scores visual acuity. The grid consists of 100 units whose unequal size and distribution reflect the unequal functional value of different parts of the field-in effect a weighted or relative-value scale. Because each unit equals 1 percent, a simple count of units yields the functional score in percent." . [] oboInOwl:hasDbXref "PMID:27847630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030602 ; owl:annotatedTarget "Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030609 ; owl:annotatedTarget "Loss of the outer nuclear layer (photoreceptor layer) as assessed by ocular coherence tomography." . [] oboInOwl:hasDbXref "PMID:27847630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030631 ; owl:annotatedTarget "Increased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging." . [] oboInOwl:hasDbXref "PMID:27847630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030632 ; owl:annotatedTarget "Decreased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030636 ; owl:annotatedTarget "Occult macular dystrophy is a, typically hereditary, abnormality of the macula associated with progressive foveal cone dysfunction and no apparent fundoscopic, full-field electroretinogram (ERG), or fluorescein angiogram abnormalities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030637 ; owl:annotatedTarget "Retinal phenotype characterised by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, colour vision abnormalities, nystagmus and photophobia." . [] oboInOwl:hasDbXref , "PMID:20719302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030652 ; owl:annotatedTarget "Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39417 ; owl:annotatedTarget "branched-chain saturated fatty acid" . [] oboInOwl:hasDbXref "PMID:10206815", "PMID:12666213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030654 ; owl:annotatedTarget "Any cystic lesion associated with the umbilical cord." . [] oboInOwl:hasDbXref "PMID:25184085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030655 ; owl:annotatedTarget "An entwining of a segment of umbilical cord, usually without obstructing fetal circulation and commonly result from fetal slippage through a loop of the cord." . [] oboInOwl:hasDbXref "PMID:26366000", "PMID:29201670" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030658 ; owl:annotatedTarget "Insertion of the umbilical cord within 2 cm from the placental edge." . [] oboInOwl:hasDbXref "PMID:26366000" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030659 ; owl:annotatedTarget "Insertion of the umbilical cord into the chorio-amniotic membranes of the placenta." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39417 ; owl:annotatedTarget "branched saturated fatty acid" . [] oboInOwl:hasDbXref "PMID:20029143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030661 ; owl:annotatedTarget "Yellow-white inflammatory aggregates in the vitreous that are found in the midvitreous and inferior periphery." . [] oboInOwl:hasDbXref "PMID:15557460", "PMID:7867814" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030663 ; owl:annotatedTarget "Vestigial vitreous gel occupying the immediate retrolental space and minimal to no discernable gel in the central vitreous cavity, giving the appearance of an empty vitreous cavity." . [] oboInOwl:hasDbXref "PMID:2146943" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030664 ; owl:annotatedTarget "Weakness of the inferior portion of the rectus abdominal muscle, which is ascertained clinically as follows. When a patient sits up or raises the head from a recumbent position, the umbilicus is displaced toward the head. This is the result of paralysis of the inferior portion of the rectus abdominal muscle, so that the upper fibres predominate pulling upwards the umbilicus." . [] oboInOwl:hasDbXref "PMID:6568936" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030665 ; owl:annotatedTarget "Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements." . [] oboInOwl:hasDbXref "PMID:23329331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030666 ; owl:annotatedTarget "In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment." . [] oboInOwl:hasDbXref , "PMID:22076700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030667 ; owl:annotatedTarget "A type of retinal neovascularization that affects the periphery of the retina." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39417 ; owl:annotatedTarget "branched saturated fatty acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39417 ; owl:annotatedTarget "branched-chain saturated fatty acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030671 ; owl:annotatedTarget "Any anomaly of the ring of fibrous tissue that surrounds the optic nerve at its entrance at the apex of the orbit. The common tendinous ring, also known as the annulus of Zinn or annular tendon, is the origin for five of the seven extraocular muscles." . [] oboInOwl:hasDbXref "PMID:8152765" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030673 ; owl:annotatedTarget "A form of vitreoretinopathy characterized by thinning (erosion) of the retinal pigment epithelium that permits increased visualization of the choroidal vessels." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030674 ; owl:annotatedTarget "Onset prior to birth." . [] oboInOwl:hasDbXref "PMID:19152421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030676 ; owl:annotatedTarget "Sharp pointed superior portion of the ear, with variable overfolding of the helix." . [] oboInOwl:hasDbXref "PMID:21587051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030677 ; owl:annotatedTarget "A congenital auricular deformity, which is mainly characterized by a bulging appearance of the anterosuperior portion of the auricle, a convexly protruded cavum conchae, and a slit-like narrowing of the orifice of the external auditory meatus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39418 ; owl:annotatedTarget "PMID:15644336" . [] oboInOwl:hasDbXref , "PMID:23761491", "PMID:9637809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030679 ; owl:annotatedTarget "A hypopigmented spot in the shape of a leaf from the mountain ash tree." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39418 ; owl:annotatedTarget "straight-chain saturated fatty acid" . [] oboInOwl:hasDbXref "PMID:16670098", "PMID:25443708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030682 ; owl:annotatedTarget "Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39418 ; owl:annotatedTarget "straight-chain saturated fatty acids" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "UM-BBD_compID:c0135" . [] oboInOwl:hasDbXref , "PMID:26221520" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030684 ; owl:annotatedTarget "A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030685 ; owl:annotatedTarget "A reduced circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "Gmelin:1999" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "dihydrogen(tetraoxidophosphate)(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030687 ; owl:annotatedTarget "A deviation from the normal concentration of glucagon in the blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "dihydrogenphosphate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "dihydrogentetraoxophosphate(1-)" . [] oboInOwl:hasDbXref , "PMID:23291329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030706 ; owl:annotatedTarget "A ranula is a mucocele that occurs in the floor of the mouth and usually involve the major salivary glands. Specifically, the ranula originates in the body of the sublingual gland, in the ducts of the sublingual gland, in the Wharton's duct of the submandibular gland or infrequently from the minor salivary glands at this location." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030707 ; owl:annotatedTarget "Unilateral pulmonary agenesis" . [] oboInOwl:hasDbXref , "PMID:20885122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030708 ; owl:annotatedTarget "The severe form of a neural tube defect where the open neural tube appears as a flattened, plate-like mass of nervous tissue with no overlying membrane." . [] oboInOwl:hasDbXref , "PMID:9514174" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030709 ; owl:annotatedTarget "Myelocystocele is characterized by a large, ependyma-lined, cystic dilation of the caudal end of the central canal of the spinal cord; it projects dorsally through a lamina defect, with overlying varying amounts of lipomatous subcutaneous tissue. Myelocystoceles are associated with a tethered cord and meningocele, which communicates with the spinal subarachnoid space, but not with the central canal cyst." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030710 ; owl:annotatedTarget "A form of closed neural tube defect in which the spinal tissue lies within the spinal cord having a junction between the spinal cord and the lipoma. Intact skin covers the defect. Neurologic findings first appear during the second year of life." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030711 ; owl:annotatedTarget "Distention of the vagina caused by accumulation of fluid due to congenital vaginal obstruction." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "dihydrogentetraoxophosphate(V)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030712 ; owl:annotatedTarget "Adhesions or scar tissue that form inside the cavity of the uterus." . [] oboInOwl:hasDbXref , "PMID:32706613", "PMID:33168212" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030713 ; owl:annotatedTarget "Vein of Galen aneurysmal malformation is a choroidal type of arteriovenous malformation that develops between 6 and 11 weeks of gestation. It results from 1 or more arteriovenous fistulas shunting blood toward the prosencephalic vein of Markowski, the embryonic precursor of the vein of Galen. This abnormal shunt leads to progressive dilation of the vein and prevents its involution and subsequent development into the vein of Galen." . [] oboInOwl:hasDbXref , "PMID:11125254" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030714 ; owl:annotatedTarget "A large maternal clot that separates the chorionic plate from the villous chorion." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "dihydroxidodioxidophosphate(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030715 ; owl:annotatedTarget "A developmental anomaly characterised by focal obliteration of the proximal segment of a bronchus. The bronchial pattern is entirely normal distal to the site of stenosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030716 ; owl:annotatedTarget "Partial or complete absence of the flat bones of the cranial vault. The condition is frequently, though not always, associated with anencephaly." . [] oboInOwl:hasDbXref , "PMID:3317498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030717 ; owl:annotatedTarget "Peritonitis caused by intrauterine intestinal rupture and spillage of fetal meconium into the fetal peritoneal cavity. Intra-peritoneal meconium usually calcifies, sometimes within 24 hours. Ultrasound findings may include intraabdominal calcifications." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "DIHYDROGENPHOSPHATE ION" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030718 ; owl:annotatedTarget "Increase in size of the right atrium." . [] oboInOwl:hasDbXref , "PMID:14246338" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030719 ; owl:annotatedTarget "A form of agenesis of the tricuspid valve in which (although the normal orifice between the right atrium and right ventricle exists) there is no tricuspid valvular tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030720 ; owl:annotatedTarget "Cyst on the surface of the placenta consisting of amnion and chorion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030721 ; owl:annotatedTarget "Phocomelia involving all four extremities." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "H2PO4(-)" . [] oboInOwl:hasDbXref , "PMID:11988792", "PMID:637502" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030722 ; owl:annotatedTarget "Ectopic liver is a rare developmental anomaly in which liver tissue is situated outside the liver. Thus, ectopic liver refers to autonomous islands of normal liver parenchyma located outside the liver. The term ectopic liver is also used, to include liver appendices attached to the native liver by a thin stalk although being fully separated from the latter." . [] oboInOwl:hasDbXref , "PMID:20981865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030723 ; owl:annotatedTarget "Dilation and elongation of the penile urethra associated with absence or hypoplasia of the corpora spongiosa and cavernosa." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "SARCOSINE" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_39745 ; owl:annotatedTarget "[PO2(OH)2](-)" . [] oboInOwl:hasDbXref , "PMID:11593239", "PMID:24455569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030724 ; owl:annotatedTarget "A fluid-filled sac (cyst) located within the central nervous system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030724 ; owl:annotatedTarget "CNS cyst" . [] oboInOwl:hasDbXref , "PMID:20890417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030725 ; owl:annotatedTarget "The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030726 ; owl:annotatedTarget "A neurenteric cyst located in the spine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030727 ; owl:annotatedTarget "A neurenteric cyst located within the skull." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030728 ; owl:annotatedTarget "Partial absence of a free limb (excluding girdle). It can refer to the proximal, middle or distal segment of the upper or lower limb. The deficiency may be transverse or longitudinal. Thus, meromelia is a lack of a part, but not all, of one or more limbs with the presence of a hand or foot." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3992 ; owl:annotatedTarget "Cyclic ketone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030729 ; owl:annotatedTarget "A herniation of meninges through a congenital bone defect in the skull at the junction of the frontal and ethmoidal bones." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030730 ; owl:annotatedTarget "A herniation of meninges through a congenital bone defect in the skull in the parietal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030731 ; owl:annotatedTarget "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus)." . [] oboInOwl:hasDbXref , , "PMID:2007717", "PMID:26059011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030732 ; owl:annotatedTarget "A congenital malformation of the tricuspid valve characterized by leaflet deformation." . [] oboInOwl:hasDbXref , , "PMID:2521673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030733 ; owl:annotatedTarget "An abdominal wall defected related to a developmental anomaly of the allantois, which is an embryonic structure that develops as a diverticulum off the yolk sac at about 16 days post fertilization. During further development, the allantois becomes incorporated into the body of the embryo, connecting the ventral aspect of the urogenital sinus (which will develop into the upper pole of the urinary bladder) to the external portion of the umbilicus. Upon further development, the lumen of the allantois becomes obliterated and forms a thick fibrous cord called the urachus, which connects the apex of the bladder to the umbilicus. In adults, the urachus is known as the median umbilical ligament. Failure of the allantoic cavity to obliterate can result of one of four conditions: 1) congenital patent urachus (a completely open connection between bladder and umbilicus); 2) vesicourachal diverticulum (a diverticulum off the bladder but not communicating with the umbilicus); umbilical cyst and sinus (not communicating with the bladder); and 4) alternating urachal sinus. An abdominal wall defect can be associated with a urachal cyst." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_3992 ; owl:annotatedTarget "cyclic ketones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030735 ; owl:annotatedTarget "Blockage at the level of the bladder and the ureter caused by stenosis of the ureteral valves or failure of a narrow juxtavesical ureteral segment to dilate due to segmented fibrosis or localized absence of muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030736 ; owl:annotatedTarget "A teratoma arising in the sacro-coccygeal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030737 ; owl:annotatedTarget "A type of sacrococcygeal teratoma that is predominantly external and projects from the sacrococcygeal region and presents with distortion of the buttocks." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030738 ; owl:annotatedTarget "A type of sacrococcygeal teratoma that is predominantly external but has a large intrapelvic component." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030739 ; owl:annotatedTarget "A type of sacrococcygeal teratoma that is predominantly intrapelvic with a small external, buttock mass." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030740 ; owl:annotatedTarget "An accessory (not normally present) muscle bundle in the right ventricle which obstructs the right ventricular outflow tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030741 ; owl:annotatedTarget "A teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs)." . [] a owl:Axiom ; rdfs:label "Mediastinal teratoma" ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:HP_0030741 ; owl:annotatedTarget "NCIT:C6438" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030743 ; owl:annotatedTarget "Persistance of a posterior remnant of the hyaloid artery located at the optic disc." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030744 ; owl:annotatedTarget "A type of persistance of the hyaloid vascular system associated with a retrolental mass that may lead to fetal cataract." . [] oboInOwl:hasDbXref , "PMID:10898444", "PMID:11788230", "PMID:27433265", "PMID:29656824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030745 ; owl:annotatedTarget "Ductus arteriosus aneurysm (DAA) is a saccular dilatation of the ductus arteriosus. DAA can be either congenital or acquired (e.g. as a complication of surgical closure of a patent ductus arteriosus). Although the majority of patients with congenital DAA are asymptomatic and have a benign course, severe complications, such as rupture or thromboembolism, can occur. DAA is likely to emerge in the third trimester from the aortic junction of the DA, extending towards its pulmonary end." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030746 ; owl:annotatedTarget "Bleeding into the ventricles of the brain." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030746 ; owl:annotatedTarget "Intraventricular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030747 ; owl:annotatedTarget "Intraventricular hemorrhage that occurs in a premature infant." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030747 ; owl:annotatedTarget "Preterm intraventricular haemorrhage" . [] oboInOwl:hasDbXref , "PMID:25371784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030748 ; owl:annotatedTarget "Intraventricular hemorrhage that occurs in a preterm infant and that is restricted to subependymal region/germline matrix which is seen in the caudothalamic groove." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030748 ; owl:annotatedTarget "Germinal matrix haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030748 ; owl:annotatedTarget "Grade I preterm intraventricular haemorrhage" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "Beilstein:2938799" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030749 ; owl:annotatedTarget "Intraventricular hemorrhage that occurs in a preterm infant and that has extension into normal-sized ventricles and typically fills less than 50% of the volume of the ventricle." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030749 ; owl:annotatedTarget "Grade II preterm intraventricular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030750 ; owl:annotatedTarget "Intraventricular hemorrhage that occurs in a preterm infant and that has extension into dilated ventricles." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030750 ; owl:annotatedTarget "Grade III preterm intraventricular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030751 ; owl:annotatedTarget "Intraventricular hemorrhage that occurs in a preterm infant and that shows parenchymal extension." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030751 ; owl:annotatedTarget "Grade IV preterm intraventricular haemorrhage" . [] oboInOwl:hasDbXref , "PMID:19205594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030752 ; owl:annotatedTarget "A nasolacrimal duct obstruction presenting as a grey-blue cystic swelling just below the medial canthus. Believed to be a result of concomitant upper obstruction of the Rosenmuller valve and lower obstruction of the Hasner valve." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:jdavis", "PMID:10732306", "PMID:2187353", "PMID:24361180", "PMID:2704493", "PMID:9699754" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030753 ; owl:annotatedTarget "Loss of one twin occurring after midgestation (17 weeks gestation)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030753 ; owl:annotatedTarget "Intrauterine foetal demise of one twin after midgestation" . [] oboInOwl:hasDbXref , "PMID:24950576", "PMID:26213613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030754 ; owl:annotatedTarget "A swelling formed at the base of umbilicus associated with a patent urachus which results from an allantoic remnant. The urachus is a fibrous remnant of the allantois which communicates from the apex of the urinary bladder to the umbilicus. Failed obliteration of the urachus can lead to various abnormalities: urachal cyst, urachal diverticulum, sinus or patent urachus - the most common type. Allantoic cysts in infants with patent urachus can be formed due to the drainage of urine into the umbilical cord, or in uncommon situations, after leakage of hypo-osmotic urine into the Wharton's jelly." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "CAS:150-05-0" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030755 ; owl:annotatedTarget "A teratoma located in the craniofacial region." . [] oboInOwl:hasDbXref "PMID:21731282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030756 ; owl:annotatedTarget "Reddish, brown opalescent discoloration of teeth in normal light." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030757 ; owl:annotatedTarget "A pocket of pus located within a region of a tooth." . [] oboInOwl:hasDbXref , "PMID:25148116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030759 ; owl:annotatedTarget "An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy." . [] oboInOwl:hasDbXref , "PMID:16408108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030760 ; owl:annotatedTarget "Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease." . [] oboInOwl:hasDbXref , "PMID:32866505", "PMID:6353041" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030762 ; owl:annotatedTarget "Partial or complete dissolution of the mesangial matrix, identified by reduced staining on a periodic acid-Schiff (PAS) or silver stain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030763 ; owl:annotatedTarget "A sheet like projection that can result from uterine synechiae that has been encompassed by the expanding chorion and amnion." . [] oboInOwl:hasDbXref , "PMID:24447956", "PMID:26929770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030764 ; owl:annotatedTarget "Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved." . [] oboInOwl:hasDbXref "PMID:20736106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030766 ; owl:annotatedTarget "Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030766 ; owl:annotatedTarget "Ear pain" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "Reaxys:2938799" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030766 ; owl:annotatedTarget "Pain in the ear" . [] oboInOwl:hasDbXref , "PMID:19240824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030767 ; owl:annotatedTarget "Epignathus is a teratoma originating from the upper jaw, usually connected with the sphenoid bone or hard palate." . [] oboInOwl:hasDbXref , "PMID:21887200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030769 ; owl:annotatedTarget "A malformation of the neural tube with a large amount of protruding brain tissue and absence of calvarium." . [] oboInOwl:hasDbXref , "PMID:22095531" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030770 ; owl:annotatedTarget "A neural tube defect in which both the brain and spinal cord remain open to varying degrees." . [] oboInOwl:hasDbXref , "PMID:24839413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030771 ; owl:annotatedTarget "Mallet finger refers to a condition in which the end joint of a finger bends but will not straighten by itself. In this situation, the joint can be pushed straight but will not hold that position on its own." . [] oboInOwl:hasDbXref , "PMID:21438051", "PMID:23915863" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030772 ; owl:annotatedTarget "Proximal femoral focal deficiency is a deformity manifested by hypoplasia of a variable portion of the femur with shortening of the entire limb." . [] oboInOwl:hasDbXref , "PMID:1344079", "PMID:21687160", "PMID:25145891" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030773 ; owl:annotatedTarget "An abnormality of conjugate lateral gaze in which the affected eye shows impairment of adduction. The pathognomonic clinical sign of internuclear ophthalmoplegia is an impaired adduction while testing horizontal saccades on the side of the lesion in the ipsilateral medial longitudinal fascicule." . [] oboInOwl:hasDbXref , "PMID:22907871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030774 ; owl:annotatedTarget "The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures." . [] oboInOwl:hasDbXref , "PMID:24162519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030775 ; owl:annotatedTarget "An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic." . [] oboInOwl:hasDbXref , "PMID:24162519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030776 ; owl:annotatedTarget "An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "(S)-adrenaline" . [] oboInOwl:hasDbXref , "PMID:24162519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030777 ; owl:annotatedTarget "An abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow." . [] oboInOwl:hasDbXref , "PMID:24162519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030778 ; owl:annotatedTarget "An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1 and T2-weighted sequences. Modic type III signals are thought to correspond to subchondral sclerosis seen on plain radiographs." . [] oboInOwl:hasDbXref , "PMID:23248551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030779 ; owl:annotatedTarget "Ethmocephaly is the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain. Clinically, the disease presents with a proboscis, hypotelorism, microphthalmos and malformed ears." . [] oboInOwl:hasDbXref , "PMID:12970121", "PMID:15943976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030780 ; owl:annotatedTarget "An anomaly of the protein C anticoagulant pathway, which serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. A natural anticoagulant system denoted the protein C pathway exerts its anticoagulant effect by regulating the activity of FVIIIa and FVa. The vitamin K-dependent protein C is the key component of the pathway. Activated protein C (APC) cleaves and inhibits coagulation cofactors FVIIIa and FVa, which result in downregulation of the activity of the coagulation system. The endothelial protein C receptor stimulates the T-TM-mediated activation of protein C on the endothelial cell surface. The two cofactors, protein S and the intact form of FV, enhance the anticoagulant activity of APC." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030781 ; owl:annotatedTarget "A higher than normal levels of the fatty acids which can occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues." . [] oboInOwl:hasDbXref , "PMID:28487810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030782 ; owl:annotatedTarget "An abnormal amount of any of the interleukins, a class of cytokines, in the circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030782 ; owl:annotatedTarget "Abnormal serum IL level" . [] oboInOwl:hasDbXref , "PMID:9883970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030783 ; owl:annotatedTarget "An increased concentration of interleukin-6 in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030783 ; owl:annotatedTarget "Increased serum IL-6" . [] oboInOwl:hasDbXref , "PMID:18348092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030784 ; owl:annotatedTarget "An inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030784 ; owl:annotatedTarget "Word-finding difficulty" . [] oboInOwl:hasDbXref , "PMID:25821300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030785 ; owl:annotatedTarget "A lymphangioma (congenital malformation consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures) located within the mediastinum, i.e., the central compartment of the thoracic cavity that is surrounded by loose connective tissue. Mediastinal lymphangioma is a slow growing mass with benign features, and accounts for 1% of all mediastinal tumors." . [] oboInOwl:hasDbXref , "PMID:10506812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030786 ; owl:annotatedTarget "Perceived flashes of light." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030787 ; owl:annotatedTarget "Any anomaly of the cerumen (ear wax), the yellowish waxy substance secreted in the ear canal." . [] oboInOwl:hasDbXref , "PMID:15256605" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030788 ; owl:annotatedTarget "Blockage of the external auditory canal by a buildup of earwax." . [] oboInOwl:hasDbXref "PMID:probinson" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030789 ; owl:annotatedTarget "An increased quantity of earwax." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030790 ; owl:annotatedTarget "An anomolous earwax color. Earwax (cerumen) is usually light to dark brown or orange in color." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030791 ; owl:annotatedTarget "A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030792 ; owl:annotatedTarget "A tumor originating in the jaw (mandible or maxilla)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030793 ; owl:annotatedTarget "Abnormal enlargement in the upper jaw (maxilla) or in the lower jaw (mandible)." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "(+)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol" . [] oboInOwl:hasDbXref , "PMID:15198367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030794 ; owl:annotatedTarget "An anomolous circulating concentration of the connecting (C) peptide, which links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. After cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030795 ; owl:annotatedTarget "A decreased concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with reduced insulin secretion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030796 ; owl:annotatedTarget "An elevated concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with increased insulin secretion." . [] oboInOwl:hasDbXref , "PMID:7477289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030797 ; owl:annotatedTarget "A diminished volume of the central part of the bed nucleus of the stria terminalis." . [] oboInOwl:hasDbXref , "PMID:12600711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030798 ; owl:annotatedTarget "The stria terminalis is a slender, compact fiber bundle that connects the amygdala (amygdaloid body) with the hypothalamus and other basal forebrain regions. The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. This term refers to an anomaly of the bed nucleus." . [] oboInOwl:hasDbXref , "PMID:16156241", "PMID:23960302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030799 ; owl:annotatedTarget "Scaphocephaly is a subtype of dolichocephaly where the anterior and posterior aspects of the cranial vault are pointed (boat-shaped). Scaphocephaly is caused by a precocious fusion of sagittal suture without other associated synostosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030800 ; owl:annotatedTarget "An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030801 ; owl:annotatedTarget "A decreased ability of the eye to adjust and thereby enable sharp vision of objects at different distances." . [] oboInOwl:hasDbXref , "PMID:10946945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030802 ; owl:annotatedTarget "Inferior malposition of the lower eyelid margin without eyelid eversion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030803 ; owl:annotatedTarget "Abnormal flat nail." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "Sarcosine" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "(+)-adrenaline" . [] oboInOwl:hasDbXref , "PMID:22016269", "PMID:26273150" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030804 ; owl:annotatedTarget "Excessive longitudinal ridging that gives the surface of the nail plate a rough appearance. It results from multiple foci of defective keratinization of the proximal nail matrix." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030805 ; owl:annotatedTarget "Lack of the lunula at the base of a nail. The lunula is the crescent-shaped whitish area of the bed of a fingernail or toenail." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030805 ; owl:annotatedTarget "Absent lunulae" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030805 ; owl:annotatedTarget "Lunulae absent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "(S)-(+)-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030806 ; owl:annotatedTarget "Nails whose growth is quicker than normal." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "(S)-4-(1-hydroxy-2-(methylamino)ethyl)pyrocatechol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030807 ; owl:annotatedTarget "Nail whose growth pattern or speed deviates from normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030808 ; owl:annotatedTarget "The cuticle (properly known as the eponychium, or the medial nail fold or the proximal nail fold), is the thickened layer of skin surrounding fingernails and toenails. Its function is to protect the area between the nail and epidermis from exposure to bacteria. This term refers to the presence of and irregular edge or outline of the cuticle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030811 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the tongue." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "d-adrenaline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030812 ; owl:annotatedTarget "Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_40751 ; owl:annotatedTarget "d-epinephrine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030813 ; owl:annotatedTarget "Lack of observable tonsillar tissue." . [] oboInOwl:hasDbXref , "PMID:19470903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030814 ; owl:annotatedTarget "A phenomenon of orange colored oral tonsils. This feature is characteristic of Tangier disease and illustrated will by Figure 1 of PMID:19470903." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030814 ; owl:annotatedTarget "Orange discoloured tonsils" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030815 ; owl:annotatedTarget "A lipoma localized to the tongue. May present as a nontender, soft, spherical mass of the tongue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030817 ; owl:annotatedTarget "Severe nail curvature, causing the tip of the nail to point downwards with respect to the axis of the finger. Beaked nails are caused by resorption of the distal digit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030819 ; owl:annotatedTarget "Nails that slope upward at the free edge." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030820 ; owl:annotatedTarget "Eyelid partly covered by skin when eyes are open." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030823 ; owl:annotatedTarget "Increased dimension of the sclera in the anterior-posterior axis." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41402 ; owl:annotatedTarget "CARBOXYMETHYL GROUP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030824 ; owl:annotatedTarget "Change in the color of the fundus from red in the dark-adapted state to golden immediately or shortly after the onset of the light. The color of the fundus reflex in the light adapted state has also been described as golden-yellow, gray-white, and yellow-white. This reflex can appear either homogeneous or in streaks in the fundus. The retinal vessels appear to be protruding in contrast to the radiant background. Dark adaptation leads to disappearance of the unusual fundus coloration [Digital Journal of Ophthalmology 2008; Volume 14, Number 14]." . [] oboInOwl:hasDbXref , "PMID:27491360" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030825 ; owl:annotatedTarget "Lack of the foveal reflex, which normally occurs as a result of the reflection of light from the ophthalmoscope in the foveal pit upon examination. The foveal reflex is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030826 ; owl:annotatedTarget "Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030826 ; owl:annotatedTarget "Muscle twitches in eye lid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030826 ; owl:annotatedTarget "Muscle twitches in eyelid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030826 ; owl:annotatedTarget "Twitching around eyes" . [] oboInOwl:hasDbXref , "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030828 ; owl:annotatedTarget "A high-pitched whistling sound associated with labored breathing." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030828 ; owl:annotatedTarget "Wheezing" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030829 ; owl:annotatedTarget "An anomalous (adventitious) sound produced by the breathing process." . [] oboInOwl:hasDbXref , "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030830 ; owl:annotatedTarget "Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41402 ; owl:annotatedTarget "carboxymethyl" . [] oboInOwl:hasDbXref , "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030831 ; owl:annotatedTarget "Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030833 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030833 ; owl:annotatedTarget "Neck pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030834 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030834 ; owl:annotatedTarget "Shoulder pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030835 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030835 ; owl:annotatedTarget "Elbow pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030836 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030836 ; owl:annotatedTarget "Wrist pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030837 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41402 ; owl:annotatedTarget "-CH2-COOH" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030837 ; owl:annotatedTarget "Finger pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030838 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030838 ; owl:annotatedTarget "Hip pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030839 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0030839 ; owl:annotatedTarget "Pain under knee cap" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030839 ; owl:annotatedTarget "Knee pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030840 ; owl:annotatedTarget "Ankle pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030841 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030841 ; owl:annotatedTarget "Toe pain" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030842 ; owl:annotatedTarget "Incidents in which a piece of food or other objects get stuck in the upper airway and provoke coughing, gagging, inability to talk, and difficulty breathing." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41402 ; owl:annotatedTarget "aspartic acid side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "sarcosine" . [] oboInOwl:hasDbXref , "PMID:16186440" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030843 ; owl:annotatedTarget "Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030844 ; owl:annotatedTarget "Absent response to a pattern electroretinogram (PERG)." . [] oboInOwl:hasDbXref , "PMID:12786876", "PMID:25587479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030845 ; owl:annotatedTarget "Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "Beilstein:3600898" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030846 ; owl:annotatedTarget "An anomaly of venous function." . [] oboInOwl:hasDbXref , "PMID:24085809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030847 ; owl:annotatedTarget "An anomaly of the jugular venous pressure. The internal jugular veins, being continuous with the superior vena cava, provide a visible measure of the degree to which the systemic venous reservoir is filled. The vertical height above the right atrium to which they are distended and above which they are in a collapsed state provides an imperfect reflection of the right atrial pressure." . [] oboInOwl:hasDbXref , "PMID:24085809" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030849 ; owl:annotatedTarget "The examiner applies firm but persistent pressure over the liver for 10 seconds while observing the mean jugular venous pressure. Normally there is either no rise or only a transient (i.e., 2 to 3 sec) rise in mean jugular venous pressure. A sustained increase in the mean venous pressure until abdominal compression is released is abnormal and indicates impaired right heart function. This abnormal response is called hepatojugular reflux." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030850 ; owl:annotatedTarget "An anomaly of the pulse pressure, which is defined as the systolic pressured minus the diastolic pressure." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030851 ; owl:annotatedTarget "Reduced amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030852 ; owl:annotatedTarget "Increased amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure)." . [] oboInOwl:hasDbXref , "PMID:21731561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030853 ; owl:annotatedTarget "An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body." . [] oboInOwl:hasDbXref , "PMID:22454726" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030854 ; owl:annotatedTarget "A staphyloma is a localized defect in the eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." . [] oboInOwl:hasDbXref , "PMID:24600153" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030855 ; owl:annotatedTarget "A localized defect in the anterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "CAS:3812-32-6" . [] oboInOwl:hasDbXref , "PMID:25376120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030856 ; owl:annotatedTarget "A localized defect in the posterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure." . [] oboInOwl:hasDbXref , "PMID:12928305" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030857 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye that is worse in certain directions of gaze and during prolonged gaze holding." . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030858 ; owl:annotatedTarget "Addictive behaviour" . [] oboInOwl:hasDbXref , "PMID:16112028", "PMID:31858335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030859 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against topoisomerase I." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030860 ; owl:annotatedTarget "Abnormal CSF A[beta]42 level" . [] oboInOwl:hasDbXref , "PMID:25274969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030863 ; owl:annotatedTarget "Widening of the nostrils upon inhalation as a manifestation of respiratory distress." . [] oboInOwl:hasDbXref "PMID:25274969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030864 ; owl:annotatedTarget "A pulling inward of the soft tissues between the ribs upon inhalation. This is a sign of increased use of the chest muscles for breathing and is a manifestation of respiratory distress." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030865 ; owl:annotatedTarget "Abnormal increased size of the elbow joint." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030866 ; owl:annotatedTarget "Abnormally increased size of the knee joint." . [] oboInOwl:hasDbXref , "PMID:7795293" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030867 ; owl:annotatedTarget "The orbits do not lie on the same horizontal plane, that is, one eye is lower than the other." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "Gmelin:1559" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030867 ; owl:annotatedTarget "Eyes at different heights" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030867 ; owl:annotatedTarget "Misaligned eyes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030867 ; owl:annotatedTarget "Unequal eye height" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030868 ; owl:annotatedTarget "Having only one testis in the scrotum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030869 ; owl:annotatedTarget "An abnormality of XY sexual development characterized by the absence of both testes at birth." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "carbonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030870 ; owl:annotatedTarget "An anomaly of the small joints located between and behind adjacent vertebrae." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "trioxidocarbonate(2-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030871 ; owl:annotatedTarget "Osteoarthritis of facet joints in the spine. Degeneration of cartilage in the facet joints results in bone rubbing on bone and reactive new bone formation visible on X-ray." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030872 ; owl:annotatedTarget "An abnormality of the cardiac ventricular function." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "CARBONATE ION" . [] oboInOwl:hasDbXref , "PMID:17444587", "PMID:31858335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030873 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against the centromeres or centromere components." . [] oboInOwl:hasDbXref , "PMID:24121092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030874 ; owl:annotatedTarget "Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030874 ; owl:annotatedTarget "O2 desaturation on exertion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030875 ; owl:annotatedTarget "A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030876 ; owl:annotatedTarget "Pulmonary capillary wedge pressure (PCWP) above 15mmHg." . [] oboInOwl:hasDbXref , "PMID:22347750", "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030877 ; owl:annotatedTarget "Abnormally low FEV1/FVC (FEV1 - forced expiratory volume in 1 second; FVC forced vital capacity)." . [] oboInOwl:hasDbXref , "PMID:22347750", "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030878 ; owl:annotatedTarget "Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography." . [] oboInOwl:hasDbXref , "PMID:23247773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030879 ; owl:annotatedTarget "Presence of thickening of the interlobular septa of the lungs as seen on a CT scan." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0030880 ; owl:annotatedTarget "Excessively reduced blood flow in response to cold or emotional stress, causing discolouration of the fingers, toes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030881 ; owl:annotatedTarget "Trapping and compression of the rotator cuff tendons during shoulder movements." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "CO3(2-)" . [] oboInOwl:hasDbXref , "PMID:28374180" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030882 ; owl:annotatedTarget "Enlargement of the diameter (cross-section) of a coronary artery as defined by a focal dilation of a segment at least 1.5 times larger than the reference vessel." . [] oboInOwl:hasDbXref "PMID:22108232" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030883 ; owl:annotatedTarget "Femoroacetabular impingement (FAI) results from one or more bony abnormalities that lead to abnormal contact between the acetabulum and the femoral head or neck. The femoral abnormality is proposed to cause compression and shear stresses in the region between the labrum and cartilage, anterosuperiorly. These stresses cause a separation between the labrum and cartilage as the labrum is pushed outwards and the cartilage is pushed centrally. This eventually leads to articular degeneration and eventually global hip osteoarthritis." . [] oboInOwl:hasDbXref "PMID:11827911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030884 ; owl:annotatedTarget "Feeding problem necessitating gastrojejunal tube feeding." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030885 ; owl:annotatedTarget "Increased susceptibility to parasitic infections, as manifested by recurrent episodes of parasitic infection." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "Karbonat" . [] oboInOwl:hasDbXref , "PMID:17562483" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030886 ; owl:annotatedTarget "A anomaly in the rate of programmed cell death (apoptosis) in lymphocytes." . [] oboInOwl:hasDbXref "PMID:18209785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030889 ; owl:annotatedTarget "Substantially shortened length of the small intestine as a result of a developmental defect." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41609 ; owl:annotatedTarget "[CO3](2-)" . [] oboInOwl:hasDbXref "PMID:15576652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030890 ; owl:annotatedTarget "A brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter." . [] oboInOwl:hasDbXref "PMID:15576652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030891 ; owl:annotatedTarget "Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030891 ; owl:annotatedTarget "PVWMH" . [] oboInOwl:hasDbXref "PMID:15576652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030892 ; owl:annotatedTarget "Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030892 ; owl:annotatedTarget "DWMH" . [] oboInOwl:hasDbXref , "PMID:20004088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030893 ; owl:annotatedTarget "Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030894 ; owl:annotatedTarget "No fall in mean pulmonary arterial pressure (mPAP) falls by at least 10 mmHg to an absolute value less than 40 mmHg without a degradation in cardiac output (CO) in response to a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "(methylamino)acetic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030895 ; owl:annotatedTarget "An anomaly of the muscular contractions that propel food though the gastrointestinal tract." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030895 ; owl:annotatedTarget "Abnormal GI motility" . [] oboInOwl:hasDbXref "PMID:22206545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030896 ; owl:annotatedTarget "A deviation from the normal amount of time required for food to pass through the intestines." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030896 ; owl:annotatedTarget "Abnormal GI transit time" . [] oboInOwl:hasDbXref "PMID:22206545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030897 ; owl:annotatedTarget "A reduction in the length of time required for food to pass through the intestines." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030900 ; owl:annotatedTarget "Itchy feet" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030900 ; owl:annotatedTarget "Itchy foot" . [] oboInOwl:hasDbXref , "PMID:12122165", "PMID:21250236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030902 ; owl:annotatedTarget "A type of primitive reflex characterized by an involuntary contraction of the mentalis muscle of the chin caused by stimulation of the thenar eminence of the palm." . [] oboInOwl:hasDbXref , "PMID:12700289" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030903 ; owl:annotatedTarget "A type of primitive reflex that can be elicated when the hand of the examiner is gently inserted into the palm of the patient's hand. The palmar surface is stroked or simply touched. The flexor surfaces of the fingers may be stimulated also by the examiner's fingers. The stimulus should be in a distal direction. With a positive response, the patient grasps the examiner's hand with variable strength and continues to grasp as the examiner's hand is moved. Ability to release the grip voluntarily depends on the activity of the reflex; some patients can do so readily, while others can even be lifted off the bed, since the grasp has such power [NCBI Books:NBK395]." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030904 ; owl:annotatedTarget "A type of primitive reflex that is elicited by repetitive tapping on the forehead. Normal subjects usually blink in response to the first several taps, but if blinking persists, the response is abnormal and considered to be a sign of frontal release. Persistent blinking is also known as Myerson's sign." . [] oboInOwl:hasDbXref "PMID:21250236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030905 ; owl:annotatedTarget "A type of primitive reflex that is elicited by tapping the upper lip lightly. The contraction of the muscles causes the mouth to resemble a snout." . [] oboInOwl:hasDbXref "PMID:21250236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030906 ; owl:annotatedTarget "A type of primitive reflex that is elicited by lightly touching or tapping on the lips with an object such as a tongue blade, reflex hammer, or the examiner's finger. At times the reflex is obtained merely by approaching the lips with an object. A positive suck reflex consists of sucking movements by the lips when they are stroked or touched." . [] oboInOwl:hasDbXref "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030908 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030908 ; owl:annotatedTarget "Anti-LKM-1 positive" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030908 ; owl:annotatedTarget "Anti-LKM1 antibody positivity" . [] oboInOwl:hasDbXref "PMID:7806169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030909 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against a 60-kd peptide contained in the liver cytosolic fraction." . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030911 ; owl:annotatedTarget "Two clitorides located side by side." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Beilstein:1281604" . [] oboInOwl:hasDbXref "PMID:23650202" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030913 ; owl:annotatedTarget "Marked rugae formation of the skin of the labia majora." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "CAS:2280-44-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030914 ; owl:annotatedTarget "An anomaly of the wave-like muscle contractions of the digestive tract." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Gmelin:83256" . [] oboInOwl:hasDbXref "PMID:18788889", "PMID:26078585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030936 ; owl:annotatedTarget "Abnormal layering of the intestinal muscularis propria into three layers; (1) inner circular; (2) additional oblique; and (3) outer longitudinal layer." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030946 ; owl:annotatedTarget "Bumps under the upper eyelid" . [] oboInOwl:hasDbXref "PMID:26543300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030948 ; owl:annotatedTarget "Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030948 ; owl:annotatedTarget "Elevated serum GGT" . [] oboInOwl:hasDbXref "PMID:21798099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030951 ; owl:annotatedTarget "Excessive formation of fibrous bands of scar tissue in between muscle fibers." . [] oboInOwl:hasDbXref , "PMID:25667738", "PMID:33845003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030952 ; owl:annotatedTarget "Multiple cream-yellow colored hypopigmented lesions typically located at the level of the choroid or retinal pigment epithelium; ovoid, cream-colored with indistinct borders. They are between 50 and 1,500 micrometers in size with a characteristic nasal, radial distribution in the postequatorial fundus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030952 ; owl:annotatedTarget "Birdshot laesions" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030953 ; owl:annotatedTarget "Conjunctival hyperaemia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:15987845" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "PMID:5846101", "PMID:6018320" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030958 ; owl:annotatedTarget "Bowing (bulging out) of the membranous part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030958 ; owl:annotatedTarget "Interventricular septum membranous part aneurysm" . [] oboInOwl:hasDbXref "PMID:5846101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030959 ; owl:annotatedTarget "Bowing (bulging out) of the muscular part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:17336832" . [] oboInOwl:hasDbXref "PMID:28540066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030965 ; owl:annotatedTarget "The elastic properties of the aorta allow the aorta to store half of the cardiac ejected blood volume per beat, whereby aortic recoil during diastole pushes the remaining stored volume forward into the peripheral circulation, a phenomenon known as the Windkessel function. Aortic stiffness occurs as the elastic fibers within the arterial wall become disrupted due to mechanical stress (with age or due to other factors). Aortic stiffness refers to a reduction in the elasticity of the aorta, which is associated with an elevated pulse pressure, increased wave reflection, and often hypertension." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "(methylamino)ethanoic acid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:17439666" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:17928662" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:19913595" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:26812026" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030972 ; owl:annotatedTarget "Abnormal systemic BP" . [] oboInOwl:hasDbXref "PMID:25695122", "PMID:26904705", "PMID:32105793", "PMID:33071931" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030973 ; owl:annotatedTarget "Post-exertional symptom exacerbation (PESE), also referred to as post-exertional malaise (PEM), is defined as the worsening of symptoms that can follow minimal cognitive, physical, emotional, or social activity, or activity that could previously be tolerated. Symptoms typically worsen 12 to 72 hours after activity and can last for days or even weeks, sometimes leading to a relapse." . [] oboInOwl:hasDbXref "PMID:25780588" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030974 ; owl:annotatedTarget "A type of oligozoospermia in which spermatozoa can be detected in an ejaculate only after centrifugation and inspection of the pellet." . [] oboInOwl:hasDbXref "PMID:17690130", "PMID:18842761", "PMID:25691269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030975 ; owl:annotatedTarget "An abnormal curved or vaulted (capped) structure covering the middle third of the dorsal pontine tegmentum and projecting into the fourth ventricle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030977 ; owl:annotatedTarget "Increased activity of the coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X." . [] oboInOwl:hasDbXref , "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030978 ; owl:annotatedTarget "A reduction below normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration." . [] oboInOwl:hasDbXref "PMID:26026923" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030979 ; owl:annotatedTarget "Enlargement of the large blood vessels in the choroid." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:32619908" . [] oboInOwl:hasDbXref , "PMID:24123328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030980 ; owl:annotatedTarget "An decrease in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "PMID:27388694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030981 ; owl:annotatedTarget "A deviation from the normal range of the ratio of the albumin concentration in the cerebrospinal fluid (CSF) to the concentration in serum (which may be defined as 3.2-9.0). This is an index of blood-brain barrier (BBB) integrity, adjusted for the serum albumin concentration, and an increased ratio is taken as a sign of a loss of integrity of the BBB with leakage of albumin into the CSF." . [] oboInOwl:hasDbXref "NCIT:C1882229", "PMID:27284435" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030983 ; owl:annotatedTarget "A sex cord-stromal tumor of the ovary. Thecomas range from small tumors to large solid or solid-cystic masses of up to 15 cm. They are unilateral in over 90 percent of cases and are rarely malignant. Thecomas are stromal tumors made up of cells that resemble theca cells, lutein cells and fibroblasts. They are traditionally classified within the sex cord-stromal tumor category of ovarian tumor types." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:7524207" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:9140037" . [] oboInOwl:hasDbXref "PMID:21994886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030986 ; owl:annotatedTarget "Hyperplasia of lining epithelia of the septal and large bile ducts manifesting as micropapillary projections or as a stratification of the epithelium with or without dilatation of the duct lumen." . [] oboInOwl:hasDbXref "PMID:21994886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030987 ; owl:annotatedTarget "Cholangitis characterized by the presence of numerous polymorphonuclear cells around and within the wall as well as within the lumen of the ducts. This may involve ducts of any size and is occasionally associated with abscess formation (cholangitic abscess)." . [] oboInOwl:hasDbXref "PMID:22333006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030988 ; owl:annotatedTarget "Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts." . [] oboInOwl:hasDbXref "PMID:21994886" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030989 ; owl:annotatedTarget "Cholangitis characterized by a close association between duct branches, usually interlobular bile ducts, and lymphocytic aggregates, which may show a follicular arrangement." . [] oboInOwl:hasDbXref "PMID:24265565" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030992 ; owl:annotatedTarget "Any structural anomaly of the pancreatic duct, which is the tubular structure that collects exocrine pancreatic secretions and transports them to the duodenum." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:9501190" . [] oboInOwl:hasDbXref "PMID:24265565" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030994 ; owl:annotatedTarget "A congenital anomaly of the pancreas that results from failed fusion of the dorsal and ventral ducts during embyological development. Three variants have been described: type 1 or classical divisum in which there is total failure of fusion; type 2 in which dorsal drainage is dominant in the absence of the duct of Wirsung; and type 3 or incomplete divisum where a small communicating branch is present." . [] oboInOwl:hasDbXref "PMID:17767107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0030998 ; owl:annotatedTarget "Drainage of cerebrospinal fluid through the nose. This can occur when there is a fistula between the dura and the skull base and discharge of cerebrospinal fluid (CSF) from the nose." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030998 ; owl:annotatedTarget "CSF rhinorrhoea" . [] oboInOwl:hasDbXref "PMID:6722516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031004 ; owl:annotatedTarget "Areflexia that is limited to one side of the body." . [] oboInOwl:hasDbXref "PMID:24808861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031008 ; owl:annotatedTarget "Involuntary protrusions, movements, spams and contortions of the tongue." . [] oboInOwl:hasDbXref "PMID:26379327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031009 ; owl:annotatedTarget "Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation." . [] oboInOwl:hasDbXref "PMID:27738187", "PMID:30728880" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031010 ; owl:annotatedTarget "An accessory phalanx of the third (middle) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint." . [] oboInOwl:hasDbXref "PMID:8181179" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031011 ; owl:annotatedTarget "Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV." . [] oboInOwl:hasDbXref "PMID:27500096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031012 ; owl:annotatedTarget "Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring less than 65 micrometers and typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031012 ; owl:annotatedTarget "TCFA" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:9506998" . [] oboInOwl:hasDbXref "PMID:25105156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031014 ; owl:annotatedTarget "Usually, three large arteries arise from the arch of the aorta: the brachiocephalic trunk (divided into the right common carotid artery and the right subclavian artery), the left common carotid artery, and the left subclavian artery. However, when aberrant right subclavian artery variant is present, the brachiocephalic trunk is absent and four large arteries arise from the arch of the aorta: the right common carotid artery, the left common carotid artery, the left subclavian artery, and the final one with the most distal left sided origin, the right subclavian artery, also called the arteria lusoria." . [] oboInOwl:hasDbXref "PMID:25796481" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031015 ; owl:annotatedTarget "Sclerosis of the intrahepatic portal veins of the liver and generally accompanied by non-cirrhotic portal hypertension, features of which may include splenomegaly and varices." . [] oboInOwl:hasDbXref "PMID:28384951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031016 ; owl:annotatedTarget "Areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra." . [] oboInOwl:hasDbXref "PMID:18559707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031017 ; owl:annotatedTarget "Multiple defects in the atrial septum." . [] oboInOwl:hasDbXref "NCIT:CL017969", "PMID:26937300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031018 ; owl:annotatedTarget "Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA)." . [] oboInOwl:hasDbXref "PMID:16702501" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031023 ; owl:annotatedTarget "Multiple painful, dome-shaped, translucent pink to skin-colored papules on oral mucosa. Histologically, the lesions may demonstrate dermal proliferation of well-demarcated nerve bundles associated with abundant mucin and surrounded by a distinct perineural sheath." . [] oboInOwl:hasDbXref "NCIT:C27094", "PMID:27294061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031024 ; owl:annotatedTarget "A benign skin adnexal tumor of eccrine differentiation." . [] oboInOwl:hasDbXref "NCIT:C27200", "PMID:25069607" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031025 ; owl:annotatedTarget "A malignant neoplasm of the stomach that grows submucosally in the gastric wall. Necrosis and hemorrhage may be visible radiologically. Histologically, spindle cells with abnormal mitotic activity may be visible." . [] oboInOwl:hasDbXref "PMID:3799723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031026 ; owl:annotatedTarget "The ilia is round and hypoplastic with a very flat acetabular roof and a very unusual medial projection of bone that is said to resemble the head of a snail. Figure 4 of PMID:3799723 illustrates this feature." . [] oboInOwl:hasDbXref "PMID:11694546", "PMID:24339047" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031027 ; owl:annotatedTarget "A small V-shaped indentation on the internal aspect of the femoral head. This feature is well illustrated in Figure 5 of PMID:11694546." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "PMID:9545565" . [] oboInOwl:hasDbXref "PMID:15368719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031028 ; owl:annotatedTarget "Serum sample with a grossly white (milk-like, i.e., lactescent) appearance. This feature is indicative of an extremely elevated serum triglyceride level." . [] oboInOwl:hasDbXref "PMID:11274010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031029 ; owl:annotatedTarget "An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031029 ; owl:annotatedTarget "Increased plasma CEA" . [] oboInOwl:hasDbXref "PMID:16343244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031030 ; owl:annotatedTarget "An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031030 ; owl:annotatedTarget "Increased plasma CA125" . [] oboInOwl:hasDbXref "PMID:14749226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031031 ; owl:annotatedTarget "A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol." . [] oboInOwl:hasDbXref "PMID:14749226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031032 ; owl:annotatedTarget "A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity." . [] oboInOwl:hasDbXref "PMID:6876936" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031033 ; owl:annotatedTarget "The kidney contributes towards acid-base homeostasis by excreting H+ ions and retaining bicarbonate. This process is known as acidification of the urine. The pH of urine ranges normally from 4.5 to 8. The inability to reduce the pH of the urine in a situation where it would be otherwise expected is known as an acidification defect." . [] oboInOwl:hasDbXref "PMID:20142246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031034 ; owl:annotatedTarget "A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031036 ; owl:annotatedTarget "Decreased plasma GH-binding protein" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "L-sarcosine" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Reaxys:1281604" . [] oboInOwl:hasDbXref "PMID:24640568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031037 ; owl:annotatedTarget "Blood concentration of insulin-like factor 3 (ILF3) is below normal limits." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031037 ; owl:annotatedTarget "Reduced plasma INSL3 level" . [] oboInOwl:hasDbXref "PMID:21684558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031038 ; owl:annotatedTarget "Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa." . [] oboInOwl:hasDbXref "PMID:21684558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031039 ; owl:annotatedTarget "A type of maturation arrest in which only spermatogonia or spermatocytes are found." . [] oboInOwl:hasDbXref "PMID:21684558", "PMID:9510006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031040 ; owl:annotatedTarget "A failure of spermatogenesis to progress beyond the round spermatid stage. The round spermatid is the first haploid cells produced during spermatogenesis and normally further develop into mature spermatozoa. This abnormality can be visualized with testicular biopsy and is characterized seminiferous tubules with increased numbers of round spermatids with few or no mature spermatozoa." . [] oboInOwl:hasDbXref "PMID:26222562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031042 ; owl:annotatedTarget "Inflammed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry." . [] oboInOwl:hasDbXref "PMID:8387724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031043 ; owl:annotatedTarget "A type of brachydactyly characterized by brachymesophalangy affecting mainly the 2nd and 5th digits." . [] oboInOwl:hasDbXref "PMID:18554391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031044 ; owl:annotatedTarget "A type of brachydactyly characterized by absent middle phalanges of digits 2 to 5." . [] oboInOwl:hasDbXref "PMID:11420024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031046 ; owl:annotatedTarget "A developmental defect characterized by lack of a soft palate." . [] oboInOwl:hasDbXref "PMID:17403946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031047 ; owl:annotatedTarget "An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "D-glucopyranose" . [] oboInOwl:hasDbXref "PMID:12057070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031049 ; owl:annotatedTarget "An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031052 ; owl:annotatedTarget "Elevated circulating VEGF concentration" . [] oboInOwl:hasDbXref "PMID:23909637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031054 ; owl:annotatedTarget "Coarctation of the aorta is a narrowing or constriction of a long segment of the arch of the aorta." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "D-Glc" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031057 ; owl:annotatedTarget "Cracked skin" . [] oboInOwl:hasDbXref "PMID:10362969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031059 ; owl:annotatedTarget "This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing." . [] oboInOwl:hasDbXref "PMID:10362969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031060 ; owl:annotatedTarget "This applies to an individual who needs help with dressing or needs to be completely dressed." . [] oboInOwl:hasDbXref "PMID:10362969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031062 ; owl:annotatedTarget "Applies to an individual who needs help in moving from bed to chair or requires a complete transfer." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "D-Glcp" . [] oboInOwl:hasDbXref "PMID:19562053" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031067 ; owl:annotatedTarget "A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "D-Glucose" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "D-glucose" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031077 ; owl:annotatedTarget "Abnormal response to CRH stimulation test" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031083 ; owl:annotatedTarget "Abnormal response to hCG stimulation test" . [] oboInOwl:hasDbXref "PMID:21791970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031084 ; owl:annotatedTarget "An abnormally high increase in insulin levels following a glucagon stimulation test." . [] oboInOwl:hasDbXref "PMID:17138848" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031085 ; owl:annotatedTarget "A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status." . [] oboInOwl:hasDbXref "PMID:12584384" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031086 ; owl:annotatedTarget "Undescended or ectopic ovaries are characterized by the attachment of the upper pole of the ovary to an area above the level of the common iliac vessels." . [] oboInOwl:hasDbXref "PMID:21702402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031088 ; owl:annotatedTarget "Persistent vaginal dryness." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031089 ; owl:annotatedTarget "Palatal oedema" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Dextrose" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031089 ; owl:annotatedTarget "Palate oedema" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031090 ; owl:annotatedTarget "Sausage fingers" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031091 ; owl:annotatedTarget "Sausage toes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Glc-OH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031097 ; owl:annotatedTarget "Abnormal TSH level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031098 ; owl:annotatedTarget "Decreased plasma TSH" . [] oboInOwl:hasDbXref "PMID:12790766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031099 ; owl:annotatedTarget "Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Glucose" . [] oboInOwl:hasDbXref "PMID:11720872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031100 ; owl:annotatedTarget "A reduced concentration of inhibin B in the blood." . [] oboInOwl:hasDbXref "PMID:22693172" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031101 ; owl:annotatedTarget "Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031102 ; owl:annotatedTarget "Increased plasma AMH" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031103 ; owl:annotatedTarget "Decreased plasma AMH" . [] oboInOwl:hasDbXref "PMID:3280181" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031104 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "Grape sugar" . [] oboInOwl:hasDbXref "PMID:23771171" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031106 ; owl:annotatedTarget "An abnormality of the uterus characterized by a normal uterine outline but with an abnormal T-shaped uterine cavity with narrowing cavity due to thickened lateral walls with a correlation 2/3 uterine corpus and 1/3 cervix. The abnormlaity is said to resemble the letter T in hysterosalpingographic imaging." . [] oboInOwl:hasDbXref "PMID:19283655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031110 ; owl:annotatedTarget "As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure." . [] oboInOwl:hasDbXref "PMID:17467434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031117 ; owl:annotatedTarget "A type of bicuspid aortic valve (BAV) characterized by two equal-sized cusps, with no raphe and only two commissures. There is a lateral arrangement of the free edge of the cusps. Note that this differs from some other forms of BAV in which there are three commissures and two of the three cusps are joined by a raphe forming two functional leaflets. This type of BAV often is associated with aortic stenosis." . [] oboInOwl:hasDbXref "PMID:17467434", "PMID:24827036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031118 ; owl:annotatedTarget "A type of bicuspid aortic valvue (BAV) characterized by the presence of a single raphe that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps, resulting in two leaflets of unequal size." . [] oboInOwl:hasDbXref "PMID:17467434", "PMID:24827036" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031119 ; owl:annotatedTarget "A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and left cusps (RL fusion pattern). This results in two leaflefts with an anterior-posterior leaflet orientation (also called the typical pattern). There is thus one completely developed noncoronary cusp, two completely developed commissures, and one raphe between the underdeveloped left and right coronary cusps extending to the corresponding malformed commissure." . [] oboInOwl:hasDbXref "PMID:17467434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031122 ; owl:annotatedTarget "A type of bicuspid aortic valvue (BAV) characterized by the presence of two raphes that each extend from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV has developmental anlagen of three cusps, commissures, and sinuses, but two commissures are more or less malformed and obliterated, giving rise to a raphe, a fibrous ridge, which extends from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV is typically associated with a high degree of aortic stenosis." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031130 ; owl:annotatedTarget "Impaired Ca ionophore-induced platelet aggregation" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031130 ; owl:annotatedTarget "Impaired Ca2+ ionophore-induced platelet aggregation" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "MeGly" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" . [] oboInOwl:hasDbXref "PMID:12814644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031131 ; owl:annotatedTarget "An abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement." . [] oboInOwl:hasDbXref "PMID:22379596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031134 ; owl:annotatedTarget "A developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4167 ; owl:annotatedTarget "glucose" . [] oboInOwl:hasDbXref "PMID:22145138" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031138 ; owl:annotatedTarget "A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP)." . [] oboInOwl:hasDbXref "PMID:21472065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031141 ; owl:annotatedTarget "Increased echogenicity of liver tissue on sonography, manifested as an increased amount of white on the screen of the sonography device." . [] oboInOwl:hasDbXref "PMID:21472065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031142 ; owl:annotatedTarget "Any deviation from the normal degree of echogenicity of the liver on sonography. Echogenicity refers to the ability of a tissue to reflect or transmit ultrasound waves in the context of surrounding tissues. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. Based on echogenicity, a structure can be characterized as hyperechoic (white on the screen), hypoechoic (gray on the screen) and anechoic (black on the screen)." . [] oboInOwl:hasDbXref "PMID:21472065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031143 ; owl:annotatedTarget "Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device." . [] oboInOwl:hasDbXref "PMID:26157918" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031145 ; owl:annotatedTarget "An abnormal echotexture visible in liver ultrasound manifesting as a diffuse hyperechoic liver echotexture with multiple, small hypoechoic lesions. The appearance is said to resemble a starry sky (multiple white spots on a dark background)." . [] oboInOwl:hasDbXref "PMID:16776766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031146 ; owl:annotatedTarget "An abnormality of swallowing characterized by reduced tongue coordination to form bolus after chewing. Food material spreads over the oral cavity instead of being concentrated into a bolus that is easily swallowed." . [] oboInOwl:hasDbXref "PMID:24053995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031150 ; owl:annotatedTarget "Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "Beilstein:1696981" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031150 ; owl:annotatedTarget "VMA" . [] oboInOwl:hasDbXref "PMID:24053995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031151 ; owl:annotatedTarget "Vitreomacular traction is characterized by anomalous posterior vitreous detachment accompanied by anatomic distortion of the fovea, which may include pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid. Vitreomacular traction can be subclassified by the diameter of vitreous attachment to the macular surface as measured by OCT, with attachment of 1500 micrometers or less defined as focal and attachment of more than 1500 micrometers as broad." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031151 ; owl:annotatedTarget "VMT" . [] oboInOwl:hasDbXref "PMID:24053995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031152 ; owl:annotatedTarget "Full-thickness macular hole (FTMH) is defined as a foveal lesion with interruption of all retinal layers from the internal limiting membrane to the retinal pigment epithelium. Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than vitreomacular traction. Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of vitreomacular traction." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031152 ; owl:annotatedTarget "FTMH" . [] oboInOwl:hasDbXref "PMID:20513134", "PMID:21921955" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031153 ; owl:annotatedTarget "Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane." . [] oboInOwl:hasDbXref "PMID:20513134", "PMID:21921955" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031154 ; owl:annotatedTarget "Vitreous humor of the eye displaying beaded bundles of irregular diameters." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031155 ; owl:annotatedTarget "Increased Arden ratio of EOG" . [] oboInOwl:hasDbXref "PMID:11157507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031156 ; owl:annotatedTarget "Decreased platelet cell membrane concentration of glycoprotein Ib." . [] oboInOwl:hasDbXref "PMID:23571267" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031157 ; owl:annotatedTarget "An abnormal connection between a carotid artery and the cavernous sinus." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "CAS:124-18-5" . [] oboInOwl:hasDbXref "PMID:22353005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031158 ; owl:annotatedTarget "An atrophic scar (fibrous connective tissue resulting from incomplete healing of a wound) that has stretched (gotten wider), a manifestation of tissue fragility." . [] oboInOwl:hasDbXref "PMID:10607719", "PMID:25662009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031160 ; owl:annotatedTarget "Impaired egress of mature neutrophils from bone marrow causing neutropenia." . [] oboInOwl:hasDbXref "PMID:24123328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031161 ; owl:annotatedTarget "An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS)." . [] oboInOwl:hasDbXref "PMID:27785002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031162 ; owl:annotatedTarget "Delay or absence of the swallow response, reflexes triggered by the contact the food bolus makes with the anterior faucial pillars." . [] oboInOwl:hasDbXref "PMID:19580459" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031163 ; owl:annotatedTarget "Reduced bone mineral density of the femur." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031164 ; owl:annotatedTarget "Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone." . [] oboInOwl:hasDbXref "PMID:27091239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031165 ; owl:annotatedTarget "Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations)." . [] oboInOwl:hasDbXref "PMID:19472919" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031167 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by eating or drinking foods rich in potassium." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031167 ; owl:annotatedTarget "Triggered by ingestion of K-rich food" . [] oboInOwl:hasDbXref "PMID:24753906" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031169 ; owl:annotatedTarget "A pregnancy that extends to 42 weeks of gestation or beyond." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "CAS:124-18-5" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031170 ; owl:annotatedTarget "Female foetal virilization" . [] oboInOwl:hasDbXref "PMID:12525546", "PMID:12966518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031174 ; owl:annotatedTarget "An anomaly of the patella characterized by two layers visible on lateral knee X-ray such that one layer is in front of the other in the sagittal orientation (See Figure 2A and 3B of PMID:12966518). This finding persists into adulthood." . [] oboInOwl:hasDbXref "PMID:15668452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031177 ; owl:annotatedTarget "Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion." . [] oboInOwl:hasDbXref "PMID:25288843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031178 ; owl:annotatedTarget "Head is bent in the posterior direction in a permanent fashion." . [] oboInOwl:hasDbXref "PMID:12060874" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031179 ; owl:annotatedTarget "Resistance of the extensor muscles of the neck to being bent forwards (i.e., impaired neck flexion) as a result of muscle spasm of the extensor muscles of the neck. Nuchal rigidity is not a fixed rigidity. Nuchal rigidity has been used as a bedside test for meningism, although its sensitivity for this purpose has been debated." . [] oboInOwl:hasDbXref "PMID:18452799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031180 ; owl:annotatedTarget "An expanding erythematous (red) skin lesion, usually round or oval, by definition at least 5 cm in size (in largest diameter)." . [] oboInOwl:hasDbXref "PMID:20054043" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031181 ; owl:annotatedTarget "Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution." . [] oboInOwl:hasDbXref "PMID:24849255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031187 ; owl:annotatedTarget "An abnormality of the concentration of pregnenolone in the blood." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031188 ; owl:annotatedTarget "Genital oedema" . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031200 ; owl:annotatedTarget "A type of acellular urinary cast that are composed only of Tamm-Horsfall glycoprotein, a fact which explains their low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "Gmelin:67816" . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031201 ; owl:annotatedTarget "A type of acelluar casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented." . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031202 ; owl:annotatedTarget "A type of acellular urinary casts that display a melted wax (waxy) appearance, which gives them a high refractive index. They are frequently dark, with blunt extremities, indented and cracked edges and a large size, which is often several times that of other types of casts." . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031203 ; owl:annotatedTarget "A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarised light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses." . [] oboInOwl:hasDbXref "PMID:26079824" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031204 ; owl:annotatedTarget "A type of urinary cast that contain bacteria. Bacterial casts can be difficult to identify and can be distinguished from other types of casts using phase contrast microscopy. Bacterial casts are diagnostic of acute pyelonephritis or intrinsic renal infection." . [] oboInOwl:hasDbXref "PMID:22227072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031205 ; owl:annotatedTarget "Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins." . [] oboInOwl:hasDbXref "PMID:27058447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031206 ; owl:annotatedTarget "Abnormally bright T2 signal from the striatum on brain magnetic resonance imaging." . [] oboInOwl:hasDbXref "NCIT:C3869", "PMID:21191518" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031207 ; owl:annotatedTarget "A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size." . [] oboInOwl:hasDbXref "PMID:18194851", "PMID:30725725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031209 ; owl:annotatedTarget "Reduction in the level of lipoprotein lipase in the blood." . [] oboInOwl:hasDbXref "PMID:11861239" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031210 ; owl:annotatedTarget "A deviation from the normal concentration of hyaluronic acid in the blood." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA11000568" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "PMID:11762597" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "Reaxys:1696981" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031213 ; owl:annotatedTarget "Elevated circulating 17-OHP" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "DECANE" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031218 ; owl:annotatedTarget "Inappropriate ADH secretion" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0031218 ; owl:annotatedTarget "SIADH" . [] oboInOwl:hasDbXref "PMID:12014928" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031226 ; owl:annotatedTarget "An accumulation of fluid in one or more of the perinephric spaces, which consist of the subcapsular, perirenal, anterior and posterior pararenal spaces. This abnormality can be demonstrated by cross-sectional imaging, particularly computed tomography." . [] oboInOwl:hasDbXref "PMID:23056797" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031227 ; owl:annotatedTarget "A teratoma arising in the nasopharyngeal region." . [] oboInOwl:hasDbXref "PMID:20082456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031228 ; owl:annotatedTarget "An abnormal shape of the incisura, defined as the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by the antitragus, and along its lower lateral margins and inferior boundary by the connection between the first two. The upper boundary is a somewhat arbitrary line crossing from the apices of the antitragus and the tragus." . [] oboInOwl:hasDbXref "PMID:20082456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031229 ; owl:annotatedTarget "The length of the incisura from the upper to lower border is greater than that observed in the average population." . [] oboInOwl:hasDbXref "PMID:20082456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031230 ; owl:annotatedTarget "The length of the incisura from the upper to lower border is less than that observed in the average population." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "N-Methylglycine" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "decane" . [] oboInOwl:hasDbXref "PMID:20082456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031231 ; owl:annotatedTarget "Width of the incisura from the anterior to posterior border less than that observed in the average population." . [] oboInOwl:hasDbXref "PMID:20082456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031232 ; owl:annotatedTarget "Breadth of the incisura from the anterior to posterior border greater than that observed in the average population." . [] oboInOwl:hasDbXref "PMID:24706940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031233 ; owl:annotatedTarget "A morphological abnormality of the scapula in which there is a flat (horizontal) inferior edge of the scapula. The entire scapula is said to resemble a square, leading to the designation sqaring of the scapula (in Figure 1 of PMID:24706940 the scapulae have a roughly rectangular shape)." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031233 ; owl:annotatedTarget "Squaring of the inferior scapulae" . [] oboInOwl:hasDbXref "PMID:17675728" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031235 ; owl:annotatedTarget "Collection of neutrophils in the epidermis." . [] oboInOwl:hasDbXref "PMID:17675728" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031236 ; owl:annotatedTarget "Collection of neutrophils in the dermis." . [] oboInOwl:hasDbXref "PMID:22938878" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031237 ; owl:annotatedTarget "An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031237 ; owl:annotatedTarget "Internally nucleated skeletal muscle fibres" . [] oboInOwl:hasDbXref "PMID:19084976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031238 ; owl:annotatedTarget "A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031238 ; owl:annotatedTarget "Necklace skeletal muscle fibres" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "CH3-[CH2]8-CH3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "Dekan" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "n-Dekan" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031244 ; owl:annotatedTarget "Enlargement of the lip typically due to fluid buildup or inflammation." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031245 ; owl:annotatedTarget "Wet cough" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031246 ; owl:annotatedTarget "Dry cough" . [] oboInOwl:hasDbXref "PMID:24219484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031247 ; owl:annotatedTarget "A type of cough characterized by a burst of numerous and rapid coughs followed by a long inhaling effort that is accompanied by a high-pitched whooping sound produced by the inhalation of air." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031248 ; owl:annotatedTarget "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031248 ; owl:annotatedTarget "Itchy palm" . [] oboInOwl:hasDbXref "PMID:21075995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031249 ; owl:annotatedTarget "A distortion of the sense of taste, often characterized by the sensation of a metallic taste." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031249 ; owl:annotatedTarget "Altered sense of taste" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41808 ; owl:annotatedTarget "n-decane" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031249 ; owl:annotatedTarget "Metallic taste" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031249 ; owl:annotatedTarget "Metallic taste in mouth" . [] oboInOwl:hasDbXref "PMID:23125071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031254 ; owl:annotatedTarget "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the thalamus." . [] oboInOwl:hasDbXref "PMID:23125071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031255 ; owl:annotatedTarget "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the hypothalamus." . [] oboInOwl:hasDbXref "PMID:23125071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031256 ; owl:annotatedTarget "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the optic nerve." . [] oboInOwl:hasDbXref "PMID:17082338", "PMID:23125071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031257 ; owl:annotatedTarget "An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the maxilla." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031259 ; owl:annotatedTarget "Inflammed ovary" . [] oboInOwl:hasDbXref "PMID:18616733" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031260 ; owl:annotatedTarget "A short, dysplastic tibia with a triangular shape. Instead of the normal shaft configuration of the tibia, the tibia forms a triangle with the longest side corresponding to the proximal-distal dimension, and the apex of the triangle directed laterally." . [] oboInOwl:hasDbXref "PMID:10662721", "PMID:26918173" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031265 ; owl:annotatedTarget "Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary." . [] oboInOwl:hasDbXref "PMID:23235479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031266 ; owl:annotatedTarget "An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031267 ; owl:annotatedTarget "Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031268 ; owl:annotatedTarget "Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR)." . [] oboInOwl:hasDbXref , "PMID:12121224" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031269 ; owl:annotatedTarget "Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031270 ; owl:annotatedTarget "Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR)." . [] oboInOwl:hasDbXref "PMID:28238385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031275 ; owl:annotatedTarget "A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage" . [] oboInOwl:hasDbXref "PMID:28785436" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031276 ; owl:annotatedTarget "A type of shock characterized by inadequate cardiac preload due to obstructed venous return (e.g. pericardial tamponade, tension pneumothorax, abdominal compartment) or obstruction of arterial blood flow (e.g. pulmonary embolism)." . [] oboInOwl:hasDbXref "PMID:22016677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031279 ; owl:annotatedTarget "An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031279 ; owl:annotatedTarget "Abnormal response to GnRH stimulation test" . [] oboInOwl:hasDbXref "PMID:22016677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031280 ; owl:annotatedTarget "An abnormally high amount of luteinizing hormone (LH) is released upon gonadotropin-releasing hormone stimulation test." . [] oboInOwl:hasDbXref "PMID:27171597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031282 ; owl:annotatedTarget "A lateral deviation of the nail plate of the great toe along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges." . [] oboInOwl:hasDbXref "PMID:24574696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031286 ; owl:annotatedTarget "Redness surrounding the hair follicles." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031287 ; owl:annotatedTarget "Senile wart" . [] oboInOwl:hasDbXref "PMID:18809899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031288 ; owl:annotatedTarget "The presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones." . [] oboInOwl:hasDbXref "PMID:14708109", "PMID:21600032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031291 ; owl:annotatedTarget "Ichthyosis follicularis is characterized by widespread non inflammatory thorn-like follicular projections. Dyskeratotic papules are most pronounced over the extensor extremities and scalp and are symmetrically distributed." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031292 ; owl:annotatedTarget "Skin abscess" . [] oboInOwl:hasDbXref "PMID:8358096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031293 ; owl:annotatedTarget "Pinhole-sized concave depressions with hyperkeratosis in the skin of a finger or toe." . [] oboInOwl:hasDbXref "PMID:12664819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031296 ; owl:annotatedTarget "An abnormal increase in the thickness of the atrial septum." . [] oboInOwl:hasDbXref "PMID:19398672" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031297 ; owl:annotatedTarget "Unroofed coronary sinus (CS) is a rare congenital cardiac anomaly in which there is partial (either focal or fenestrated) or complete absence of the roof of the CS, which results in a communication between the CS and the LA. Unroofed CS is the rarest type of atrial septal defect. It is often associated with persistent left superior vena cava (LSVC) and other forms of complex congenital heart disease, usually heterotaxia syndromes. The morphological types have been classified into 4 groups: Type I, completely unroofed with persistent LSVC; type II, completely unroofed without persistent LSVC; type III, partially unroofed mid portion; and type IV, partially unroofed terminal portion." . [] oboInOwl:hasDbXref "PMID:16301317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031300 ; owl:annotatedTarget "A deviation from the normal concentration of properdin in the blood." . [] oboInOwl:hasDbXref "PMID:24402839", "PMID:26811161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031301 ; owl:annotatedTarget "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "N-methylaminoacetic acid" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Beilstein:1210591" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "CAS:111-20-6" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "CAS:111-20-6" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "CAS:111-20-6" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Gmelin:102423" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01170006" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "PMID:7890275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031318 ; owl:annotatedTarget "A nonparallel arrangement of cardiac myocytes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031318 ; owl:annotatedTarget "Myocardial fibre disarray" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "PMID:9439441" . [] oboInOwl:hasDbXref "PMID:15066961", "PMID:7626345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031319 ; owl:annotatedTarget "An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes." . [] oboInOwl:hasDbXref "PMID:26140040" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031324 ; owl:annotatedTarget "The presence of extremely large cells with multiple nuclei. The so-called giant cells are thought to be of macrophage origin." . [] oboInOwl:hasDbXref "PMID:28456755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031326 ; owl:annotatedTarget "A type of cardiac amyloidosis related to deposition of an immunoglobulin light chain. The current gold standard of amyloid typing is to determine the precursor protein using laser microdissection mass spectrometry." . [] oboInOwl:hasDbXref "PMID:22949539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031327 ; owl:annotatedTarget "A type of cardiac amyloidosis related to deposition of transthyretin (TTR), which is identified by immunohistochemical staining." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031327 ; owl:annotatedTarget "TTR cardiac amyloidosis" . [] oboInOwl:hasDbXref "PMID:10435025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031328 ; owl:annotatedTarget "A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in perivascular spaces." . [] oboInOwl:hasDbXref "PMID:10435025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031329 ; owl:annotatedTarget "A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in interstitial spaces." . [] oboInOwl:hasDbXref "PMID:22311886", "PMID:7788887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031333 ; owl:annotatedTarget "A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes." . [] oboInOwl:hasDbXref "PMID:22948484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031336 ; owl:annotatedTarget "Abnormal localization of mitochondria within the nuclei of cardiomyocytes." . [] oboInOwl:hasDbXref "PMID:20167932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031337 ; owl:annotatedTarget "Anomalous staining of Connexin43 in cardiomyocytes. Connexin43 (Cx43) is the primary gap junction protein in the working myocardium. Cx43 exhibits increased localization at the lateral membranes of cardiomyocytes in a variety of heart diseases." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Reaxys:1210591" . [] oboInOwl:hasDbXref "PMID:25196244" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031338 ; owl:annotatedTarget "Anomalous staining of plakoglobin in cardiomyocytes. Plakoglobin is a component of desmosomes in cardiomyocytes." . [] oboInOwl:hasDbXref "PMID:23330010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031339 ; owl:annotatedTarget "Anomalous staining of dystrophin in cardiomyocytes." . [] oboInOwl:hasDbXref "PMID:11292918" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031344 ; owl:annotatedTarget "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the pelvis." . [] oboInOwl:hasDbXref "PMID:25082585" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031348 ; owl:annotatedTarget "A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the right of the pulmonary artery. This is the most common kind of TGA." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031348 ; owl:annotatedTarget "D-TGA" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031349 ; owl:annotatedTarget "L-TGA" . [] oboInOwl:hasDbXref "NCIT:C7723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031350 ; owl:annotatedTarget "A malignant soft tissue neoplasm that arises from the heart." . [] oboInOwl:hasDbXref "PMID:24932362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031351 ; owl:annotatedTarget "A non-neoplastic cardiac tumor characterized by calcification and eosinophilic amorphous material in the background of dense collagenous fibrous tissue." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031351 ; owl:annotatedTarget "Calcified amorphous tumour of the heart" . [] oboInOwl:hasDbXref , "PMID:16990972", "PMID:18405952" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031352 ; owl:annotatedTarget "An unpleasant sensation of tightness or pressure in the chest." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "SEBACIC ACID" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031353 ; owl:annotatedTarget "Otitis media characterized by thick or sticky fluid behind the tympanic membrane." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031353 ; owl:annotatedTarget "Fluid behind eardrum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031354 ; owl:annotatedTarget "Difficulty falling asleep" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031355 ; owl:annotatedTarget "Waking up several times during the night" . [] oboInOwl:hasDbXref "PMID:23716835" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031357 ; owl:annotatedTarget "A histologically distinctive, cutaneous, benign vascular tumor that is characterized by a solitary or multiple blue-red papules and histologically resembles renal glomeruli." . [] oboInOwl:hasDbXref "PMID:28499424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031361 ; owl:annotatedTarget "Intralysosomal, osmiophilic, lamellated and sometimes concentric cytoplasmic inclusions comprised of broad transversely-stacked myelinoid membranes and said to resemble a zebra in electron microscopic images." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031364 ; owl:annotatedTarget "Ecchymoses" . [] oboInOwl:hasDbXref "NCIT:C4402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031366 ; owl:annotatedTarget "A neoplasm that affects the hard palate, soft palate, or uvula." . [] oboInOwl:hasDbXref "PMID:18203204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031367 ; owl:annotatedTarget "Longitudinal densities on radiographs located in a metaphysis (the narrow region of a long bone between the epiphysis and the diaphysis)." . [] oboInOwl:hasDbXref "PMID:22334860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031369 ; owl:annotatedTarget "A hole (perforation) in the wall of the colon." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "Sar" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Sebacic acid" . [] oboInOwl:hasDbXref "PMID:28290145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031371 ; owl:annotatedTarget "A hole (perforation) in the wall of the rectum." . [] oboInOwl:hasDbXref "PMID:20803025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031372 ; owl:annotatedTarget "Increased muscle weakness upon exposure to cold temperatures." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "decanedioic acid" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "1,10-decanedioic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "1,8-dicarboxyoctane" . [] oboInOwl:hasDbXref "PMID:27107657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031385 ; owl:annotatedTarget "The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus." . [] oboInOwl:hasDbXref "PMID:27107657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031386 ; owl:annotatedTarget "The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter." . [] oboInOwl:hasDbXref "PMID:27107657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031387 ; owl:annotatedTarget "The presence of abnormally high numbers of multinucleated megakaryocytes in the bone marrow." . [] oboInOwl:hasDbXref "PMID:27107657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031388 ; owl:annotatedTarget "The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Decanedioic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41865 ; owl:annotatedTarget "Sebacinsaeure" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_4194 ; owl:annotatedTarget "D-Hexose" . [] oboInOwl:hasDbXref "PMID:29095912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031394 ; owl:annotatedTarget "Any abnormality in the relative amount of CD4+ and CD8+ T lymphocytes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_4194 ; owl:annotatedTarget "D-hexopyranose" . [] oboInOwl:hasDbXref "PMID:12133935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031396 ; owl:annotatedTarget "Any abnormality in the proportion of naive T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_4194 ; owl:annotatedTarget "D-hexose" . [] oboInOwl:hasDbXref , "PMID:12133935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031397 ; owl:annotatedTarget "An abnormally decreased proportion of naive T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4194 ; owl:annotatedTarget "D-hexoses" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "methylaminoacetic acid" . [] oboInOwl:hasDbXref "PMID:12133935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031398 ; owl:annotatedTarget "An abnormally increased proportion of naive T cells relative to the total number of T cells." . [] oboInOwl:hasDbXref "PMID:16285891", "PMID:22294241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031399 ; owl:annotatedTarget "An abnormal proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031402 ; owl:annotatedTarget "Impaired Ag-specific T cell proliferation" . [] oboInOwl:hasDbXref "PMID:11911826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031403 ; owl:annotatedTarget "Impaired response of CD8 T cells to pathogens. CD8 T cells direct the killing of a target cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." . [] oboInOwl:hasDbXref "NCIT:C27273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031405 ; owl:annotatedTarget "A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273]." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031406 ; owl:annotatedTarget "Abnormal cytokine signalling" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031407 ; owl:annotatedTarget "Cytokine signalling defect" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "Beilstein:2211017" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031407 ; owl:annotatedTarget "Impaired cytokine signalling" . [] oboInOwl:hasDbXref "PMID:15371947", "PMID:18684881", "PMID:22222639" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031408 ; owl:annotatedTarget "An increased proportion of mast cells are positive for the cell surface marker CD25 (also called interleukin-2 receptor alpha chain)." . [] oboInOwl:hasDbXref "PMID:19278419" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031410 ; owl:annotatedTarget "An abnormal distribution in the number of CD56 bright NK cells, as measured by flow cytometry. CD56, an adhesion molecule mediating homotypic adhesion, is used as a functional marker for NK cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031410 ; owl:annotatedTarget "Abnormal distribution of CD56 bright/dim NK cells" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "CAS:102-32-9" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031414 ; owl:annotatedTarget "An increased concentration of calcifediol in the blood. Calcifediol is also known as 25-hydroxycholecalciferol or 25-Hydroxyvitamin D3." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "CAS:102-32-9" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang", "PMID:24246681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031415 ; owl:annotatedTarget "An increased concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031417 ; owl:annotatedTarget "Nasal Discharge" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031417 ; owl:annotatedTarget "Runny Nose" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "CAS:102-32-9" . [] oboInOwl:hasDbXref "PMID:17973940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031418 ; owl:annotatedTarget "Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031418 ; owl:annotatedTarget "Increased BMI" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031419 ; owl:annotatedTarget "A decreased concentration of sex-hormone binding protein in the circulation." . [] oboInOwl:hasDbXref , "PMID:25323644", "PMID:28611647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031420 ; owl:annotatedTarget "A lesion that is observed following light damage to the macula. Damage to the retinal by exposure to intense visible light, usually the sun. Intense light exposure such as staring at the sun causes fine structural anomalies in the outer segments of the photoreceptors and the retinal pigment epithelium (RPE) cells of the macula. Symptoms usually develop within 1 to 4 h after exposure and include decreased vision, metamorphopsia, micropsia, and central or paracentral scotomas. Fundus examination typically shows a small yellow spot with a surrounding gray zone in the foveolar or parafoveolar area. Spontaneous evolution leads to the improvement of visual acuity." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031420 ; owl:annotatedTarget "Small yellow foveal lesion with surrounding grey zone" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031421 ; owl:annotatedTarget "Reduced size of the superior frontal portion of the cerebral cortex." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gth" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031423 ; owl:annotatedTarget "Reduced size of the cerebellar cortex." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang", "PMID:15309383" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031424 ; owl:annotatedTarget "A deviation from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation, a marker of the rate of bone turnover." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031424 ; owl:annotatedTarget "Abnormal circulating beta-CTx level" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031425 ; owl:annotatedTarget "A abnormal elevation above the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "Gmelin:874810" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031426 ; owl:annotatedTarget "A reduction from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang", "PMID:23737779", "PMID:25577163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031427 ; owl:annotatedTarget "A deviation from the normal concentration of osteocalcin in the blood circulation." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031428 ; owl:annotatedTarget "An elevated level of osteocalcin in the blood." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031429 ; owl:annotatedTarget "A reduced level of osteocalcin in the blood." . [] oboInOwl:hasDbXref "PMID:32471365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031433 ; owl:annotatedTarget "A deficit in emotional awareness characterized by difficulties in recognizing and expressing feelings and emotions manifested as a limited ability to respond to facial clues or other signs of emotions in others often accompanied by detached connections to others." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031433 ; owl:annotatedTarget "Unaware of others' emotions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031437 ; owl:annotatedTarget "Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants." . [] oboInOwl:hasDbXref "PMID:26761949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031438 ; owl:annotatedTarget "A deviation from the normal concentration in the circulation of sex hormone-binding globulin, a circulating glycoprotein that transports testosterone and other steroids in the blood." . [] oboInOwl:hasDbXref "PMID:12855585", "PMID:23555012" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031439 ; owl:annotatedTarget "A deviation from the normal concentration in the circulation of angiostatin, an endogenous angiogenesis inhibitor, which blocks the growth of new blood vessels." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:11251641" . [] oboInOwl:hasDbXref "PMID:3958362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031444 ; owl:annotatedTarget "An increase in the diameter of the ring (annulus) of the tricuspid valve." . [] oboInOwl:hasDbXref "PMID:24788242" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031451 ; owl:annotatedTarget "An abnormal increase in the amount of subcutaneous fat in the legs." . [] oboInOwl:hasDbXref "PMID:22356325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031452 ; owl:annotatedTarget "Mutliple skin lesions resembling those characteristic of the disease lichen planus. These lesions are violaceous (reddish-purple), shiny, isolated, flat-topped papules and plaques." . [] oboInOwl:hasDbXref "PMID:22356325" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031453 ; owl:annotatedTarget "Mutliple lesions of the oral mucosa resembling those characteristic of the disease lichen planus. These are symmetric reticular lesions that resemble a white, lacelike network, as well as by papules, plaques, erythematous lesions, and erosions." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:11681538" . [] oboInOwl:hasDbXref "NCIT:C43342", "PMID:17406184" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031454 ; owl:annotatedTarget "A cystic lesions that forms a benign tumor of an apocrine sweat gland." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031457 ; owl:annotatedTarget "Opacity refers to any area that preferentially attenuates the x-ray beam and therefore appears more opaque than the surrounding area. It is a nonspecific term that does not indicate the size or pathologic nature of the abnormality." . [] oboInOwl:hasDbXref "NCIT:C3377" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031459 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms." . [] oboInOwl:hasDbXref "NCIT:C4882" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031460 ; owl:annotatedTarget "A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue [NCIT:C4882]." . [] oboInOwl:hasDbXref "PMID:27298930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031461 ; owl:annotatedTarget "A benign tumor that is usually solitary, painless, palpable mass that is firm in consistency and slightly movable and often fluctuant. It can occur in any location, but tends to involve the muscles of the thighs, buttocks, and shoulders. On microscopic examination, there is abundant mucoid material and relative hypo cellularity and loose reticulin fibers. Vascular structures are sparse. The cells have a stellate shape with small hyper chromatic pyknotic nuclei and scanty cytoplasm. Some myxomas may show focal areas of hyper cellularity. However absence of nuclear atypia, mitotic figures or necrosis helps to rule out malignancy." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031461 ; owl:annotatedTarget "IM Myxoma" . [] oboInOwl:hasDbXref "NCIT:C5344", "PMID:27134598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031463 ; owl:annotatedTarget "A rare benign epithelial tumor that is usually asymptomatic but can present with pyrosis and epigastric discomfort with or without dysphagia. Histopathologically, esophageal squamous papilloma has fingerlike projections lined with acanthotic stratified squamous epithelium with conservation of normal cellular with or without cellular atypia." . [] oboInOwl:hasDbXref "PMID:26006236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031465 ; owl:annotatedTarget "A structural anomaly of vasa vasorum, which are defined as small blood vessels that supply or drain the walls of larger arteries and veins, delivering nutrients and oxygen as well as removing systemic waste products." . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031466 ; owl:annotatedTarget "A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning." . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031467 ; owl:annotatedTarget "A stable tendency to experience negative emotions, i.e., a disposition to experience aversive emotional states." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15611 ; owl:annotatedTarget "sarcosinic acid" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:11868042" . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031468 ; owl:annotatedTarget "Fears of rejection by and/or separation from significant others, associated with fears of excessive dependency and complete loss of autonomy." . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031472 ; owl:annotatedTarget "Engagement in dangerous, risky, and potentially self-damaging activities, unnecessarily and without regard to consequences; lack of concern for one's limitations and denial of the reality or personal danger." . [] oboInOwl:hasDbXref "PMID:23902698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031473 ; owl:annotatedTarget "Persistent or frequent angry feelings; anger or irritability in response to minor slights and insults." . [] oboInOwl:hasDbXref "PMID:27602219" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031474 ; owl:annotatedTarget "A benign cartilaginous tumors of the lung." . [] oboInOwl:hasDbXref , "PMID:17805245", "PMID:22528274", "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031475 ; owl:annotatedTarget "There is inconclusive evidence to precisely define the duration of the seizure; however, based on current evidence an operational threshold of 10 minutes is appropriate as beyond this a seizure is likely to be more prolonged. The individual may or may not be aware or in coma." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:15212971" . [] oboInOwl:hasDbXref "PMID:8077532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031483 ; owl:annotatedTarget "Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography." . [] oboInOwl:hasDbXref "PMID:26618117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031488 ; owl:annotatedTarget "A vascular malformation located in the lip that is characterized by direct blood shunting from an artery to a vein due to the absence of a capillary bed. The artery and vein can be directly connected by a fistula or indirectly connected by an abnormal vessel channel termed a nidus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031488 ; owl:annotatedTarget "Atypical connection between arteries and veins" . [] oboInOwl:hasDbXref "PMID:26618117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031489 ; owl:annotatedTarget "A vascular malformation located in the lip that is related to abnormal vascular morphogenesis." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:15862791" . [] oboInOwl:hasDbXref "PMID:26618117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031490 ; owl:annotatedTarget "A vascular malformation located in the lip that is related to vascular endothelial cell hyperplasia." . [] oboInOwl:hasDbXref "PMID:1918335", "PMID:28654799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031491 ; owl:annotatedTarget "Diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031491 ; owl:annotatedTarget "CSWS" . [] oboInOwl:hasDbXref "NCIT:C3709" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031492 ; owl:annotatedTarget "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709]." . [] oboInOwl:hasDbXref "NCIT:C7132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031493 ; owl:annotatedTarget "A tumor that arises from a gland cell." . [] oboInOwl:hasDbXref "PMID:24777667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031494 ; owl:annotatedTarget "Ovarian mucinous neoplasms consist of borderline tumors (tumors of low malignant potential, or LMP tumors), intraepithelial (non-invasive) carcinoma, and invasive carcinoma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031494 ; owl:annotatedTarget "Ovarian mucinous tumour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:18706927" . [] oboInOwl:hasDbXref "NCIT:C41247", "PMID:21128317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031496 ; owl:annotatedTarget "Mucin-producing and septated cyst-forming epithelial neoplasia of the pancreas with a distinctive ovarian-type stroma." . [] oboInOwl:hasDbXref "PMID:28501848" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031498 ; owl:annotatedTarget "A poorly differentiated type of gastric carcinoma with a substantial amount of extracellular mucus (over 50% of tumor volume) within the tumor." . [] oboInOwl:hasDbXref "PMID:23439060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031499 ; owl:annotatedTarget "An epithelial neoplasm originating in the appendix and often associated with cystic dilation of the appendix due to accumulation of gelatinous material, morphologically referred to as mucoceles." . [] oboInOwl:hasDbXref "NCIT:C3422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031502 ; owl:annotatedTarget "A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells [NCIT:C3422]." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031502 ; owl:annotatedTarget "Trophoblastic tumour" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031507 ; owl:annotatedTarget "Reduced T4 plasma level" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:19191673" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:22770225" . [] oboInOwl:hasDbXref "PMID:28932413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031508 ; owl:annotatedTarget "Any deviation from the normal range of the hormones produced by the thyroid gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "PMID:4420192" . [] oboInOwl:hasDbXref "PMID:2713193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031511 ; owl:annotatedTarget "Diagonal earlobe creases run from the lower pole of the external meatus, diagonally backwards to the edge of the lobe at approximately 45 degrees." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "Reaxys:2211017" . [] oboInOwl:hasDbXref "PMID:26544946" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031514 ; owl:annotatedTarget "An abnormally elevated proportion of exhausted T cells (Tex) among circulating T cells. T cell exhaustion is a distinct differentiation state that can be distinguished from naive, effector, and memory T cells. Compared to effector (TE) and memory (TMEM) T cells, exhausted T cells (TEX) display impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity). TEX have limited proliferative potential, especially compared to some subsets of TMEM and naive T cells." . [] oboInOwl:hasDbXref "PMID:27273344", "PMID:32473092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031516 ; owl:annotatedTarget "Failure of oocytes to proceed through the stages of meiosis with stoppage at the first metaphase stage." . [] oboInOwl:hasDbXref "PMID:24574658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031517 ; owl:annotatedTarget "A papillary or cauliflower-like growth characterized by the presence of foamy histiocytes within the elongated dermal papillae forms." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "(3,4-dihydroxyphenyl)acetic acid" . [] oboInOwl:hasDbXref "PMID:24574560" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031518 ; owl:annotatedTarget "Lack of normal alpha rhythm in the EEG. Alpha rhythm has been defined as a rhythm at 8-13 Hz occurring during wakefulness over the posterior regions of the head, generally with higher voltage over the occipital areas. Amplitude is variable but is mostly below 50 microvolt in adults. It is best seen with eyes closed and under conditions of physical relaxation and relative mental inactivity. It is blocked or attenuated by attention, especially visual and mental effort. One should here note the difference between the terms alpha rhythm and alpha activity: Alpha activity refers to activity in the range of 8-13 Hz and alpha rhythm is the activity of 8-13 Hz with specific characteristics as defined above." . [] oboInOwl:hasDbXref "PMID:3224502" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031519 ; owl:annotatedTarget "An anomaly of collagen fibers of the skin that is said to resemble a cauliflower and can be appreciated by electron microscopy." . [] oboInOwl:hasDbXref "NCIT:C7735", "PMID:11444201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031521 ; owl:annotatedTarget "A type of adenocarcinoma originating in the vagina and characterized by large cells with moderate to abundant clear cytoplasm." . [] oboInOwl:hasDbXref "NCIT:C6344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031522 ; owl:annotatedTarget "A type of adenocarcinoma originating in the cervix and characterized by large cells with moderate to abundant clear cytoplasm." . [] oboInOwl:hasDbXref "NCIT:C5932", "PMID:20181155" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031523 ; owl:annotatedTarget "A benign epithelial neoplasm composed of layers of oncocytes (small round nucleus, micro-granular, eosinophilic cytoplasm with numerous tightly-packed mitochondria)" . [] oboInOwl:hasDbXref "NCIT:C3908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031524 ; owl:annotatedTarget "A carcinoma originating in the ampulla of Vater (also known as the hepatopancreatic duct), which is formed by the union of the pancreatic duct and the common bile duct." . [] oboInOwl:hasDbXref "NCIT:C3146", "PMID:24376301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031525 ; owl:annotatedTarget "Keratoacanthoma (KA) is a common benign epithelial tumor that originates from the pilosebaceous glands. In most cases, it is characterized by rapid evolution, followed by spontaneous resolution over 4 to 6 months. KA usually presents as a solitary flesh-coloured nodule with a central keratin plug on the sun-exposed skin of elderly individuals." . [] oboInOwl:hasDbXref "PMID:24358988" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031534 ; owl:annotatedTarget "An abnormally increased ability to bend (dorsiflex) one's fifth finger. To assess this feature, the examiner requests to proband to extend the elbows,to bend the wrist back so that it forms a ninety degree angle to the forearm, and to extend the fingers. Then, the proband is requested to bend the fifth finger back as far as is possible without discomfort. If the angle of the fifth finger exceeds 90 degrees, this is considered to be abnormal." . [] oboInOwl:hasDbXref "PMID:27358682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031536 ; owl:annotatedTarget "Anomalous coronary origin whereby the left anterior descending (LAD) and the left circumflex artery (LCX) arise separately. Normally, these arteries arise from a common stem, the left main coronary artery (LMCA)." . [] oboInOwl:hasDbXref "PMID:27358682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031537 ; owl:annotatedTarget "An abnormal origin of the left circumflex artery (LCX) from the right coronary artery. Normally, the left anterior descending (LAD) and the LCX arise from a common stem, the left main coronary artery (LMCA)." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "2-(3,4-DIHYDROXYPHENYL)ACETIC ACID" . [] oboInOwl:hasDbXref "PMID:1097542" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031538 ; owl:annotatedTarget "Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments." . [] oboInOwl:hasDbXref "PMID:24160488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031539 ; owl:annotatedTarget "Presence of IgA antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." . [] oboInOwl:hasDbXref "PMID:24160488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031540 ; owl:annotatedTarget "Presence of IgG antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." . [] oboInOwl:hasDbXref "PMID:24160488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031541 ; owl:annotatedTarget "Presence of complement C3 in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy." . [] oboInOwl:hasDbXref "PMID:18974994" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031542 ; owl:annotatedTarget "Muscle fibers contain one or more vacuoles (membrane-bound cavity) associated with collections of membranes arranged in a whorl-like (spiral or circular) manner." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031542 ; owl:annotatedTarget "Myelin-like whorls in vacuolated fibres" . [] oboInOwl:hasDbXref "PMID:22001765" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031545 ; owl:annotatedTarget "Reduced level of T cell receptor excision circle (TRECs) as measured by the TREC assay. Late in maturation, 70% of thymocytes that will ultimately express alpha/beta-T cell receptors form a circular DNA TREC from the excised TCRdelta gene that lies within the TCRalpha genetic locus. The circles are stable but do not increase following cell division and, therefore, become diluted as T cells proliferate. A quantitative polymerase chain reaction (PCR) reaction across the joint of the circular DNA provides the TREC copy number, a marker of newly-formed, antigenically-naïve thymic emigrant T cells." . [] oboInOwl:hasDbXref "NCIT:C4469", "PMID:25387502" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031548 ; owl:annotatedTarget "A cutaneous adnexal neoplasm with variable clinical presentation. It tends to be located in the head and neck and the presentation is papulonodular, scaly, asymptomatic, measuring up to 1-2cm, simulating a basal cell carcinoma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031548 ; owl:annotatedTarget "Follicular infundibulum tumour" . [] oboInOwl:hasDbXref "PMID:24346899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031549 ; owl:annotatedTarget "Lymphocytoma cutis, or Spiegler-Fendt sarcoid, is classed as one of the pseudolymphomas, referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Careful clinical evaluation, histopathological and immunohistochemical exams may be needed to make the correct diagnosis." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "3,4-Dihydroxyphenyl acetic acid" . [] oboInOwl:hasDbXref "PMID:26240737" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031560 ; owl:annotatedTarget "An abnormal communication between coronary artery and a cardiac chamber." . [] oboInOwl:hasDbXref "MP:0011684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031561 ; owl:annotatedTarget "An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle." . [] oboInOwl:hasDbXref "PMID:22073330" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031562 ; owl:annotatedTarget "A type of double aortic arch in which the two branches are of equal size. In most cases of double aortic arch, the right aortic arch is larger and located higher than the left aortic arch." . [] oboInOwl:hasDbXref "MP:0011656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031563 ; owl:annotatedTarget "An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation." . [] oboInOwl:hasDbXref "PMID:21731561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031564 ; owl:annotatedTarget "An anomalous mirror-imaged arrangement of some bronchial structures. Right isomerism is defined as a subset of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures (vice versa for left isomerism)." . [] oboInOwl:hasDbXref "Fyler:3817" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031565 ; owl:annotatedTarget "An abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements." . [] oboInOwl:hasDbXref "Fyler:1652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031566 ; owl:annotatedTarget "Any structural anomaly of the pulmonary valve leaflets." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "3,4-Dihydroxyphenylacetic acid" . [] oboInOwl:hasDbXref "Fyler:1480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031567 ; owl:annotatedTarget "Any structural anomaly of the aortic valve leaflets." . [] oboInOwl:hasDbXref "Fyler:1486", "PMID:9360334" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031568 ; owl:annotatedTarget "An abnormally increased thickness of a leaflet of the aortic valve." . [] oboInOwl:hasDbXref "Fyler:1484", "PMID:2274446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031569 ; owl:annotatedTarget "A developmental defect characterized by the lack of aortic valve cusps (leaflets). There may be remnants of the aortic valve in form of a nonobstructive fibrous ridge or rudimentary leaflets or sinuses of Valsalva." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031570 ; owl:annotatedTarget "A Number 0 Tessier cleft is a true median cleft lip with a broad columella and bifid nasal tip. The alveolar cleft is between the central incisors. The nasal septum may be thickened, duplicated, or absent. The nasal bridge is usually broad with associated orbital hypertelorism. The midline soft tissue anomaly may range from a mild broadening of the philtrum or there may be a true median cleft lip. The columella and nasal tip are typically bifid and broadened with a midline depression. The alae nasi are intact but laterally displaced. The nose appears shortened in the vertical dimension." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031572 ; owl:annotatedTarget "As seen in a typical cleft lip, a cleft of the lip is found in the region of the cupid's bow. The nostril is cleft through the alar dome and extends above onto the nasal dorsum. It passes medial to a normal, but dys- topic, medial canthus. There is an alveolar cleft between the central and lateral incisors that extends above through the pyriform margin lateral to the anterior nasal spine; the nasal septum is not involved. The bony cleft extends through the nasal bone or between the junction of the nasal bone and frontal process of the maxilla. Above the cleft lip, the clefting of the alar dome is associated with deviation to the opposite side of the shortened and broadened columella and nasal tip. Extension of the soft tissue cleft onto the nasal dorsum can be manifest as a series of vertical soft tissue furrows and ridges. Vertical inner canthal dysto- pia and severe telecanthus mark the superior aspect of the Number 1 facial cleft. A cranial soft tissue extension characterized by a tongue-like projection of the frontal hairline delineates the number 13 cleft. Skeletal clefting of the maxilla may extend posteriorly to form a complete cleft of the hard and soft palate. The maxilla is hypoplastic in all three dimensions. There is a keel-shaped alveolus and anterior open bite. Normal septation is preserved between the nasal cavity and the hypoplastic maxillary antrum on the affected side. Distortion of the nasal skeleton produces gross flattening of the nasal dorsum. There is asymmetry of the pterygoid plates, of the greater and lesser wings of the sphenoid, and of the floor of the anterior cranial fossa. The distortion of the cranial base may result in a mild plagiocephaly." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031573 ; owl:annotatedTarget "As is typically seen in isolated cleft cases, a cleft of the lip is present. There is hypoplasia, but not true notching of the ala nasi with flattening of the lateral part of the nose. The nasal root is broadened, with lateral displacement of the inner canthus. The palpebral fissure and lacrimal drainage system are not disturbed. The alveolar cleft is through the lateral incisor area and extends to the pyriform aperture. There is normal septation between the nasal cavity and maxillary sinus. Notching at the junction between the nasal bone is present, as is a broad, flat frontal process of the maxilla. Transverse ethmoid enlargement produces orbital hypertelorism. Above the cleft of the lip and palate is a true broad cleft of the nostril that is medial to the intact, but laterally displaced, tail of the alar cartilage. A shallow soft tissue groove extends superiorly to the asymmetrically widened nasal root. The lacrimal system, palpebral fissures, and eyebrows remain intact. The alveolar cleft extends posteriorly as a complete unilateral cleft of the hard and soft palate. The nasal septum is intact but deviated to the opposite side. The nasal cavity remains separated from the normally pneumatized, although hypoplastic, maxilla on the cleft side. Above the nasomaxillary notching, the ethmoid sinus is less well developed, and there is no pneumatization of the frontal sinus on this side. Anterior rotation of the greater and lesser wings of the sphenoid occurs on the cleft side in relation to the narrower orbit and smaller ethmoid sinus. There is mild asymmetry of the anterior cranial fossa, which is narrower on the cleft side. The cranium is brachycephalic with marked occipital flattening." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "3,4-dihydroxyphenylacetic acid" . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031574 ; owl:annotatedTarget "A facial cleft characterized by involvement of the orbit." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031575 ; owl:annotatedTarget "As in the Number 1 and Number 2 clefts, this cleft extends through the lip in the region of the typical cleft lip; however, it does not extend through the base. The cleft continues superiorly to involve the inner canthus and lower eyelid medial to the inferior lacrimal punctum, thereby disrupting the nasolacrimal system. Microphthalmia may be present. The alveolar cleft is between the lateral incisor and the canine. Absent septation between the nasal cavity and maxillary antrum, together with the distortion of the frontal process of the maxilla and lacrimal fossa, produces direct communication between the orbit, maxillary sinus, and nose. There is hypoplasia of the soft tissue margins of the cleft in the vertical dimension. This produces extreme soft tissue deficiency between the alar base and the cleft of the medial aspect of the lower eyelid. The inferior lacrimal punctum is evident at the lateral margin of the lower eyelid cleft. The lacrimal drainage system ends as an opening directly onto the cheek without communication into the nasal cavity. The globe is normal in size, but it is displaced inferiorly and laterally. The nasal septum shows the characteristic distortion seen in typical cleft lip and palate. There is absence of septation between the nasal cavity on the cleft side and the maxilla. The maxilla is hypoplastic in three dimensions, with a marked reduction in pneumatization. Superior extension of the skeletal clefting into the medial portion of the orbital floor and into the inferior orbital rim in the region of the frontal process of the maxilla allows direct communication between the orbit above and the nasomaxillary region below. There is mild narrowing of the ethmoid sinus and of the body of the sphenoid on the cleft side. The pterygoid process appears anatomically normal, but less displaced from the midline compared with that of the noncleft side. Both the orbit and the floor of the anterior cranial fossa are inferiorly displaced." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031576 ; owl:annotatedTarget "The cleft lip is midway between the philtral ridge and the commissure of the mouth. The cleft is lateral to the normally shaped and placed nasal ala and passes onto the cheek. The cleft extends through the lower eyelid lateral to the punctum. The lacrimal system and inner canthus are normal. Microphthalmia may be present. The alveolar cleft passes between the lateral incisor and canine, as in the Number 3 cleft. The cleft passes around the pyriform aperture and continues through the portion of the maxillary sinus medial to the infraorbital foramen. The cleft terminates at the medial end of the inferior orbital rim. There is severe vertical soft tissue deficiency in a Number 4 cleft, with the medial margins of the cleft lip extending directly into the medially placed cleft of the lower eyelid. Within the medial segment of the right-sided cleft lip, muscle elements are apparently absent. Muscle bunching is noted in the ipsilateral lateral lip segment, as is seen in a typical unilateral cleft lip. The anatomically normal nasal ala is superiorly displaced in association with a severe deficiency in the overall nasal length. Marked dystopia of the right globe results in its inferior displacement into the medially deficient orbital floor and inferior rim. Both globes are otherwise normal. The complete palatal cleft passes through the maxilla medial to the infraorbital foramen and extends to the medial portion of the inferior orbital rim without evidence of an intact maxillary sinus. Bony septation persists medially, thereby separating the nasal cavity from the orbit, maxillary sinus, and mouth, which are contiguous. Marked midfacial hypoplasia is present. The cleft is manifest as asymmetry of the body of the sphenoid; it is smaller on the right, with asymmetric placement of the pterygoid plates relative to the midline. The orbital floor cleft has no communication with the inferior orbital fissure. The cleft does not extend to the skull base, but there is marked facial asymmetry associated with plagiocephaly." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031577 ; owl:annotatedTarget "The cleft of the lip is just medial to the oral commissure and extends across the cheek as a furrow. It ends as a cleft at the junction of the middle and lateral third of the lower eyelid. Microphthalmia is frequently present. The alveolar cleft is through the premolar region and extends superiorly through the orbit at the inferolateral part of the rim and floor. There is a vertical soft tissue deficiency between the lateral portion of the lip and the lower eyelid cleft. The left side of the nose shows vertical shortening, and the left alar base is displaced superiorly. Facial asymmetry secondary to the skeletal abnormality is reflected by a vertical orbital dystopia. However, bothglobes are normal, and there is no abnormality of the upper eyelids, eyebrow, forehead, or frontal hairline. The skeletal clefts vary, ranging from a narrow skeletal furrow that traverses the anterior maxillary wall as on the rightto a broad cleft of the maxilla lateral to the infraorbital foramen and maxillary sinus. This latter cleft enters the inferolateral orbital rim and floor without posterior communication with the inferior orbital fissure on the left side. Medial collapse of the lateral maxillary segments is present bilaterally, with reduction in the transverse dimensions of the maxillary arch. Manifestations of the skeletal disturbance in the sphenoid include a shortening and thickening of the lateral orbital walls in the region of the greater wing and mild asymmetric placement of the pterygoid plates relative to the midline. The right-sided pterygoid plates are smaller and closer to the midline. There is minimal asymmetry of the cranial base and calvarium." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031578 ; owl:annotatedTarget "A facial cleft extending from the zygomatic arch to the eye. This zygomaticomaxillary cleft is similar to that typically found in Treacher Collins syndrome. The overlying tissue shows a vertical sclerodermic furrow radiating from the labial commissure or the angle of the mandible across the cheek to a coloboma of the lower eyelid between the middle and lateral one-third. Microphthalmia is not observed. The skeletal cleft is between the maxilla and zygoma; it passes through the inferolateral orbital rim to enter the inferior orbital fissure. No alveolar cleft is present. The zygomatic arch is intact. The soft tissue furrow, which is more apparent on the right, radiates from the oral commissure toward the lateral two-thirds of the lower eyelid. The antimongoloid obliquity of the palpebral fissures is associated with laterally placed lower eyelid clefts and some ectropion. A left-sided anophthalmia is accompanied by adjacent soft tissue hypoplasia and is reflected in a short palpebral fissure, enophthalmos, and minor ptosis of the eyebrow. No abnormality is present in the alveolar arch except for some tilting of the occlusal plane secondary to hypoplasia of the left side of the maxilla. There is a vertical bony groove in the region of the zygomaticomaxillary suture that ends in the inferolateral portion of a small bony orbit. More laterally, the remainder of the zygomatic body and arch is normal in both shape and dimension. The lateral orbital floor is downslanting but intact, and it lacks direct communication with the temporal or infratemporal fossae. The hypoplasia of the left side of the maxilla and orbit is associated with a reduction in the transverse and anteroposterior dimensions of the anterior cranial fossa; mild asymmetry of the middle cranial fossa and calvarium is present. No significant asymmetry of size, shape, or position is present in the sphenoid." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031579 ; owl:annotatedTarget "The temporozygomatic Number 7 cleft is found in both Treacher Collins syndrome and hemifacial microsomia. Soft tissue manifestations include macrostomia, malformations of the external and middle ear, temporalis muscle, variable involvement of the seventh cranial nerve (in hemifacial microsomia), and abnormalities of the preauricular hair in Treacher Collins syndrome. The skeletal cleft is through the pterygomaxillary junction, and vertical maxillary hypoplasia is present. In addition, abnormality of the mandibular ramus, coronoid, and condyle and absence of the zygomatic arch are typically present. A soft tissue furrow extends from the macrostomia laterally and superiorly across the cheek toward the preauricular hairline. The lower eyelids are intact. The anatomy of the external ear is normal, and there are no preauricular tags. Bony clefting is through the pterygomaxillary junction with hypoplasia of the alveolar process in the molar region, thereby producing a posterior open bite. The maxilla is hypoplastic, although the maxillary sinuses are symmetrically pneumatized. The hypoplastic zygomatic body arches upward, but then it takes a downward course and is severely malformed and displaced. The zygoma is continuous posteriorly with an apparently normal zygomatic process of the temporal bone. The mandibular condyle and coronoid process are hypoplastic and asymmetric. There is no antegonial notching of the mandible. Marked cranial base asymmetry, with tilting and asymmetric positioning of the temporomandibular articulations, is present. The anatomy of the sphenoid is abnormal, especially on the right where there is no recognizable medial or lateral pterygoid plate." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031580 ; owl:annotatedTarget "The frontozygomatic or Number 8 cleft is found in both Treacher Collins syndrome and the Goldenhar variant of hemifacial microsomia. Skeletal defects are more prominent in Treacher Collins syndrome, whereas the soft tissue clefting is more typical in cases of ''Goldenhar syndrome''. Soft tissue clefting presents as a dermatocele, a true lateral eyelid coloboma with absence of the outer canthus, and anomalies of the globe itself, especially epibulbar cysts in patients with Goldenhar syndrome. The frontozygomatic bony cleft produces absence of the lateral orbital rim; this border now is formed by the hypoplastic greater wing of the sphenoid. The absence of bony support for the outer canthus produces lateral canthal dystopia and the characteristic antimongoloid slant of the palpebral fissures. Secondary to the bony deficiency in the lateral orbital wall and floor, there is soft tissue continuity between the orbit, temporal fossa, and infratemporal region. Preauricular hairline indicators delineate the Number 8 cleft as the first of the northbound clefts. Complete absence of the bony lateral orbital wall and rim constitute the skeletal element of the Number 8 cleft. The lateral border of the orbit is formed by the greater wing of the sphenoid from which small spicules of bone, which represent the rudimentary zygoma, may be found in Treacher Collins syndrome. The symmetry of the facial anomalies is reflected in the apparently normal symmetric anterior and middle cranial fossae." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031581 ; owl:annotatedTarget "This is an upper lateral orbital cleft. The soft tissue deformity is in the lateral one-third of the upper eyelid, and the bony cleft is through the superolateral orbital angle. Microphthalmia is present. The superolateral bony deficiency of the orbits allows a lateral displacement of the globes. The lateral one-third of the upper eyelid and the outer canthus are distorted, thus preventing apposition to the globe. The upper eyelid does not have a true cleft. A soft tissue furrow radiates superiorly and posterisphenoid is symmetric and normal. Mild cranial base asymmetry is reflected in the pterygoid plates. The left pair is more laterally displaced from the midline. Skull vault plagiocephaly is evident with an apparent reduction in the anteroposterior dimension of the anterior cranial fossa." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031582 ; owl:annotatedTarget "In a Number 10 Tessier cleft there is an upper central orbital cleft with a cleft of the middle one-third of the upper eyelid, which often results in total ablepharia. The eyebrow is disrupted, being virtually absent medially, whereas the lateral portion angles upward toward the frontal hairline. There may be ocular anomalies, including colobomata of the iris. The skeletal cleft is through the midportion of the supraorbital rim, the adjacent frontal bone, and the orbital roof lateral to the supraorbital nerve. A frontal encephalocele frequently occupies the frontal bony cleft. The palpebral fissure is grossly elongated with an amblyopic eye displaced inferiorly and laterally. There is also a divergent squint of the right eye. The eyebrow is deficient medially and becomes thinned out laterally , where it is contiguous with a broad downward and forward projection of the frontotemporal hairline (this may be seen in both the Number 9 and 10 clefts.) A broad frontal encephalocele bulges forward from the middle one-third of the right forehead, supraorbital ridge, and orbital roof. The bony cleft, through which the frontal encephalocele presents, involves the anterior half of the orbital roof, the supraorbital rim, and two-thirds of the vertical height of the frontal bone lateral to the supraorbital nerve. The bony orbit is inferiorly displaced and widened with the lateral orbital wall shortened and laterally deviated. Similar distortion of the anterior cranial fossa is evident, being broader and more flattened on the affected side. The calvarium above the level of the cleft and the cranial base below is symmetric." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031583 ; owl:annotatedTarget "An upper medial orbital cleft produces a cleft of the medial one-third of the upper eyelid that extends through the eyebrow into the frontal hairline. The skeletal element of the cleft in the region of the frontal process of the maxilla may either pass lateral to the ethmoid, through the supraorbital rim, or it may pass through the ethmoidal labyrinth to produce orbital hypertelorism. This cleft usually accompanies the Number 3 cleft. The soft tissue features include a cleft of the medial portion of the upper eyelid, an irregularity in hair orientation at the medial end of the eyebrow, and a long tongue-like projection of the frontal hairline onto the forehead. There is a mild flattening of the frontal process of the maxilla and extensive pneumatization of both the ethmoidal and frontal sinuses, both of which are more prominent on the cleft side. No bony clefting of the supraorbital rim or frontal bone is evident. The cranial base and sphenoid architecture, including the pterygoid processes, are symmetric and normal." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "dopacetic acid" . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031584 ; owl:annotatedTarget "There is a soft tissue cleft medial to the inner canthus with a cleft of the root of the eyebrow. The frontal process of the maxilla is flat and broadened, and the ethmoid labyrinth is increased in tranverse dimension, thereby producing orbital hypertelorism. The cribriform plate is of normal width. The frontal sinus is enlarged. Even though the frontal bone is flattened, bony clefts with encephalocele have not been observed. There is a lateral displacement of the inner canthus with a mild thinning, aplasia, or irregularity of the medial end of the eyebrow. There are no eyelid clefts. The soft tissue contour of the forehead is normal, with only a short downward prolongation of the paramedian frontal hairline to mark the superior extent of the soft tissue cleft. Flattening of the frontal process of the maxilla, an increase in the transverse dimension of the ethmoid sinus, and a laterally convex bowing of the medial orbital wall produce orbital hypertelorism. Superiorly there is a minor flattening of the frontal bone medially, and the nasofrontal angle is somewhat obtuse. The extensive pneumatization of the sinuses on the cleft side extends backward through the frontal and ethmoid sinuses and into the sphenoid sinus. The anatomy of the sphenoid, including the pterygoid processes, is otherwise normal. The anterior and middle cranial fossae floors are both broadened on the cleft side with minor widening of the cribriform plate." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031585 ; owl:annotatedTarget "There is a paramedian frontal encephalocele and a soft tissue cleft that passes medial to an intact eyebrow. The frontal bone shows a paramedian bony cleft with an associated encephalocele. The olfactory groove, cribriform plate, and ethmoid sinus are all increased in transverse diameter, resulting in hypertelorism. The cleft extends medially to the undisturbed eyebrow to end in a short paramedian frontal widow's peak. The bony cleft begins in the region of the nasal bone and extends superiorly through the full height of the frontal bone. Posteriorly, the cleft extends through the cribriform plate and ethmoid sinus as far as the lesser wing and body of the sphenoid. The pterygoid processes are anatomically normal, but they are displaced laterally from the midline on the cleft side. There is orbital hypertelorism below and asymmetry of the floor of the anterior cranial fossa above." . [] oboInOwl:hasDbXref "PMID:2503273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031586 ; owl:annotatedTarget "This midline cranial cleft usually occurs with a midline facial cleft that completes a median craniofacial dysraphia. A broad nasal root and bifid nose are associated with orbital hypertelorism and a median frontal encephalocele. The frontal bone abnormality varies from a minor flattening to a large midline defect. There is an increased distance between the olfactory grooves. The crista galli is widened, duplicated, or in some cases absent. Marked inferior prolapse of the enlarged ethmoid bone occurs with orbital hypertelorism. The severe orbital hypertelorism is associated with a broad flattening of the glabella and extreme lateral displacement of the inner canthi. The periorbita, including the eyelids and eyebrows, are otherwise normal. A long midline projection of the frontal hairline marks the superior extent of the soft tissue features of this midline cranial cleft. The median frontal defect delineates the region through which the frontal encephalocele herniates. The lateral segments of the frontal bone sweep upward from the region of the intact glabella and are flattened laterally. No pneumatization of the frontal sinus is evident. The crista galli and the perpendicular plate of the ethmoid are bifid. Just as the ethmoid, including the cribriform plate, is widened and caudally displaced, the sphenoid sinus is broadened and extensively, but symmetrically pneumatized. The lateral rotation of the greater and lesser wings of the sphenoid results in a relative shortening of the anteroposterior dimension of the middle cranial fossa. The floor of the anterior cranial fossa is upslanting from its medial aspect to its lateral aspect, with a harlequin appearance on the coronal scan." . [] oboInOwl:hasDbXref "PMID:22529554" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031587 ; owl:annotatedTarget "A lower midline facial cleft, also known as the median mandibular cleft. It is a rare anomaly, which may be limited to a defect in the soft tissue of the lower lip. However, in the more severe form, it may extend into the bony mandibular symphysis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031588 ; owl:annotatedTarget "Unhappy demeanour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031590 ; owl:annotatedTarget "Eye strain" . [] oboInOwl:hasDbXref "PMID:12484622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031591 ; owl:annotatedTarget "An abnormally large Eustachian valve (postnatally). The Eustachian valve is also known as the valve of the inferior vena cava, and is an embryologic remnant of the valve of the inferior vena cava." . [] oboInOwl:hasDbXref "Fyler:0102", "Fyler:102", "MP:0011253" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031592 ; owl:annotatedTarget "Situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia." . [] oboInOwl:hasDbXref "PMID:23677846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031593 ; owl:annotatedTarget "An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_41941 ; owl:annotatedTarget "homoprotocatechuic acid" . [] oboInOwl:hasDbXref "PMID:21339912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031604 ; owl:annotatedTarget "A developmental defect characterized by the lack of formation of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse." . [] oboInOwl:hasDbXref "PMID:6169833" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031606 ; owl:annotatedTarget "Fluffy white patch on the retina, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels." . [] oboInOwl:hasDbXref , "PMID:21505577" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031607 ; owl:annotatedTarget "Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position." . [] oboInOwl:hasDbXref , "PMID:24158023" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031609 ; owl:annotatedTarget "Sharply demarcated area of partial or complete depigmentation of the fundus reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss. The margins of the de-pigmented area are usually scalloped and the large choroidal vessels are visible through the atrophic retinal pigment epithelium." . [] oboInOwl:hasDbXref , "PMID:29197942" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031610 ; owl:annotatedTarget "Shoulder dislocation occurring repeated times." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031610 ; owl:annotatedTarget "Multiple shoulder dislocation" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "Beilstein:1719754" . [] oboInOwl:hasDbXref "PMID:17229799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031611 ; owl:annotatedTarget "A type of intraretinal hemorrhage that is located in the superficial retina between the inner limiting membrane and the retinal nerve fiber layer." . [] oboInOwl:hasSynonymType hp:abbreviation, hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031611 ; owl:annotatedTarget "Sub-ILM haemorrhage" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031611 ; owl:annotatedTarget "Sub-ILM hemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031611 ; owl:annotatedTarget "Sub-inner limiting membrane haemorrhage" . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031616 ; owl:annotatedTarget "An abnormal appearance of the beam of light traveling through the anterior chamber of the eye in a slit lamp examination. The flare is produced by an increased concentration of proteins in the aqueous humor in the anterior chamber." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031618 ; owl:annotatedTarget "Faint anterior chamber flare." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "Beilstein:4652748" . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031619 ; owl:annotatedTarget "Moderate anterior chamber flare (iris and lens details clear)." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031620 ; owl:annotatedTarget "Marked anterior chamber flare (iris and lens details hazy)." . [] oboInOwl:hasDbXref "PMID:16196117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031621 ; owl:annotatedTarget "Intense anterior chamber flare (fibrin/plastic aqueous)." . [] oboInOwl:hasDbXref , "PMID:28841851" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031622 ; owl:annotatedTarget "An ocular motility defect where the affected eye(s) does not elevate in adduction but has full depression in adduction. It can be congenital or acquired from injury to or defect of the superior oblique tendon or trochlea and has a positive forced duction test result." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031623 ; owl:annotatedTarget "Drooping brow" . [] oboInOwl:hasDbXref "PMID:17515479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031625 ; owl:annotatedTarget "A contained rupture of an artery with a disruption in all 3 layers of the arterial wall." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "Beilstein:5725953" . [] oboInOwl:hasDbXref , "PMID:25187745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031628 ; owl:annotatedTarget "Cardiac arrest that would have led to rapid and unexpected death had an intervention not taken place to prevent it." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031629 ; owl:annotatedTarget "Clumsy tandem walking" . [] oboInOwl:hasDbXref "PMID:23220902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031631 ; owl:annotatedTarget "So-called honeycombs (variably sized cysts in a background of densely scarred tissue) located in the subpleural space." . [] oboInOwl:hasDbXref "MP:0011745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031633 ; owl:annotatedTarget "The loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus." . [] oboInOwl:hasDbXref "PMID:27974985" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031634 ; owl:annotatedTarget "The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the main pulmonary artery." . [] oboInOwl:hasDbXref "PMID:18694519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031635 ; owl:annotatedTarget "The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the brachiocephalic artery." . [] oboInOwl:hasDbXref "PMID:12601459" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031636 ; owl:annotatedTarget "The right common carotid artery normally originates from the brachiocephalic artery. This term refers to an origin of this artery directly from the aorta." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "Gmelin:1971390" . [] oboInOwl:hasDbXref "PMID:27358682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031638 ; owl:annotatedTarget "The left anterior descending artery (LAD) branches off from the pulmonary artery." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031639 ; owl:annotatedTarget "Absent LMCA" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "PMID:15639248" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "PMID:16671745" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "PMID:7925706" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "Reaxys:1719754" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "(2S,3S)-butane-1,2,3,4-tetrol" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "L-threitol" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "D-TREITOL" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42090 ; owl:annotatedTarget "L-threo-tetritol" . [] oboInOwl:hasDbXref "PMID:27390747" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031655 ; owl:annotatedTarget "The presence of an aortic valve with four instead of the normal three cusps (flaps)." . [] oboInOwl:hasDbXref "PMID:22847594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031656 ; owl:annotatedTarget "Systolic anterior motion of the mitral valve (SAM) is a paradoxical motion of the anterior, and occasionally posterior, mitral valve leaflet towards the left ventricular outflow tract (LVOT) during systole." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031658 ; owl:annotatedTarget "S3" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031659 ; owl:annotatedTarget "S4" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031662 ; owl:annotatedTarget "Fixed splitting of S2" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031663 ; owl:annotatedTarget "Paradoxical splitting of S2" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031663 ; owl:annotatedTarget "Reversed splitting of S2" . [] oboInOwl:hasDbXref "PMID:28835836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031671 ; owl:annotatedTarget "Typical atrial flutter is an organised atrial tachycardia. It can also be defined as a macroreentrant tachycardia confined to the right atrium. This arrhythmia has a 200-260 ms cycle length, although it may fluctuate depending on patient's previous treatment or ablation, congenital heart disease, etc. Ventricular rate response will be limited by the atrioventricular node conductions, usually presenting a 2:1 or 3:1 response, during atrial flutter. Typical (counter clockwise) flutter is associated with the common flutter pattern: a regular continuous undulation with dominant negative deflections in inferior leads II, III and aVF, often described also as a saw tooth pattern, and flat atrial deflections in leads I and aVL. Atrial deflections in V1 can be positive, biphasic or negative." . [] oboInOwl:hasDbXref "PMID:28835836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031672 ; owl:annotatedTarget "A type of atrial flutter associated with rounded or bimodal positive deflections in inferior leads II, III and aVF, and a very characteristic bimodal negative wave in the shape of a W is seen in lead V1." . [] oboInOwl:hasDbXref "PMID:29234357" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031673 ; owl:annotatedTarget "A type of atrioventricular reentrant tachycardia (AVRT) where the atrioventricular node is used for anterograde conduction and the accessory pathway for retrograde conduction." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031673 ; owl:annotatedTarget "Orthodromic AVRT" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031674 ; owl:annotatedTarget "Antidromic AVRT" . [] oboInOwl:hasDbXref "PMID:29184614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031675 ; owl:annotatedTarget "A ventricular tachycardia (VT) characterized by right bundle branch block (RBBB) and left axis deviation (LAD) on electrocardiogram (ECG)." . [] oboInOwl:hasDbXref "PMID:8172861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031678 ; owl:annotatedTarget "A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from teh development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus." . [] oboInOwl:hasDbXref "PMID:8172861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031680 ; owl:annotatedTarget "Type II atherosclerotic lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid." . [] oboInOwl:hasDbXref "PMID:8172861" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031681 ; owl:annotatedTarget "Type III (intermediate) atherosclerotic lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions." . [] oboInOwl:hasDbXref "PMID:7648691" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031683 ; owl:annotatedTarget "Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031685 ; owl:annotatedTarget "Abnormal faeces composition" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0031685 ; owl:annotatedTarget "Abnormal faecal test result" . [] oboInOwl:hasDbXref "PMID:26791933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031688 ; owl:annotatedTarget "Dysplasia in the erythroid lineage, which presents with a variety of morphological changes in the bone marrow, including nuclear budding or irregular nuclear contour in erythroblasts." . [] oboInOwl:hasDbXref "PMID:27127725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031689 ; owl:annotatedTarget "The presence of micro-megakaryocytes, hypo-lobed, or non-lobed nuclei in megakaryocytes of all sizes and multiple, widely-separated nuclei." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031690 ; owl:annotatedTarget "An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system." . [] oboInOwl:hasDbXref "PMID:21960712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031691 ; owl:annotatedTarget "An unusually severe viral infection." . [] oboInOwl:hasDbXref "PMID:12588074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031692 ; owl:annotatedTarget "An unusually severe infection by cytomegalovirus." . [] oboInOwl:hasDbXref "PMID:24678403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031694 ; owl:annotatedTarget "An unusually severe adenovirus infection." . [] oboInOwl:hasDbXref "PMID:28476145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031696 ; owl:annotatedTarget "A viral infection that fails to be contained by the immune sytem and spreads throughout the body." . [] oboInOwl:hasDbXref "PMID:25452596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031697 ; owl:annotatedTarget "A dissemination viral infection caused by a live attenuated vaccine virus." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031702 ; owl:annotatedTarget "Anterior chamber RBCs" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "Beilstein:1720252" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "CAS:10326-41-7" . [] oboInOwl:hasDbXref "PMID:12751282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031711 ; owl:annotatedTarget "An abdominal aortic aneurysm that is not symmetric around its axis (not axisymmetric)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031713 ; owl:annotatedTarget "A form of divergent strabismus (exotropia) in which the eye turns outward at all distances and at all times." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031714 ; owl:annotatedTarget "A type of divergent strabismus (exotropia) in which an eye tends to turn outwards (i.e., the eye squints) mainly when looking at distant objects. The eyes tend to remain straight when they look at near objects. Distance exotropia may be constant or intermittent." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031715 ; owl:annotatedTarget "An intermittent exotropia where there is binocular single vision on distance fixation and exotropia at near (intermittent or constant)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031716 ; owl:annotatedTarget "A type of exotropia (divergent strabismus) in which binocular single vision alternates with large angle exotropia in rhythmic cycle." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "CAS:10326-41-7" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031717 ; owl:annotatedTarget "A type of exotropia in which either eye may be used for fixation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031718 ; owl:annotatedTarget "Exotropia in an individual who has previously had esotropia or esophoria." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031719 ; owl:annotatedTarget "Exotropia (intermittent or constant) on distance fixation with binocular single vision on near fixation under all testing conditions. The accommodative convergence/accommodation (AC:A) ratio is within normal limits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031721 ; owl:annotatedTarget "A type of divergent strabismus (exotropia) that develops in a poorly seeing eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031722 ; owl:annotatedTarget "An intermittent esotropia where there is binocular single vision on distance fixation and esotropia at near even when the accommodation is relieved." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031723 ; owl:annotatedTarget "Convergent squint which follows loss or impairment of vision." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031724 ; owl:annotatedTarget "A small angle heterotropia (usually of 10 diopters or less) in which a form of binocular single vision occurs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031725 ; owl:annotatedTarget "A form of latent strabismus (heterophoria) in which, on dissociation, the occluded eye deviates downwards." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031726 ; owl:annotatedTarget "A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated inward (medially) to each other." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031727 ; owl:annotatedTarget "A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated outward (laterally) to each other." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "Gmelin:362718" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031728 ; owl:annotatedTarget "A form of hypermetropia with not more than +2.00 diopters." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031729 ; owl:annotatedTarget "A form of hypermetropia with more than +2.00 diopters but not more than +5.00 diopters." . [] oboInOwl:hasDbXref , "PMID:24113300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031730 ; owl:annotatedTarget "A form of myopia related to an axial length above the norm and too long for the refractive power of the whole optical system of the eye." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031731 ; owl:annotatedTarget "Increased lacrimation owing to overproduction of tears." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031732 ; owl:annotatedTarget "A form of watery eye associated with overproduction of tears due to an increased parasympathetic drive to the secretory component of the lacrimal system (lacrimal gland); this could be due to pro-secretory drug use (e.g. pilocarpine) or autonomic disturbance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031733 ; owl:annotatedTarget "A form of watery eye associated with overproduction of tears due to reflex tearing in response to a local irritant (e.g. trichiasis or foreign body), chronic ocular surface disease (e.g. blepharitis) or systemic disease (e.g. thyroid eye disease)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031734 ; owl:annotatedTarget "A form of watery eye associated with abnormal lid tone and/or lid position. The former is due to lid laxity (common involutional change in the elderly) or a weak orbicularis muscle (e.g. due to VII cranial nerve palsy). The latter is typically associated with ectropion causing punctal eversion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031736 ; owl:annotatedTarget "An abnormal inversion of the eyelid towards the globe resulting from inferior retractor muscle dysfunction with tissue laxity and, possibly, overriding of the preseptal orbicularis muscle over the pretarsal orbicularis muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031737 ; owl:annotatedTarget "Abnormal inversion (turning inward) of the eyelid towards the globe associated with scarring that vertically shortens the posterior lamella of the eyelid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031738 ; owl:annotatedTarget "A type of entropion (abnormal inversion of the eyelid towards the globe) that is related to a mass effect of a lesion (e.g., a tumor) that pulls the eyelid margin away from the globe." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "PMID:21842515" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031739 ; owl:annotatedTarget "A functional anomaly of the inferior or superior oblique muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031741 ; owl:annotatedTarget "Reduced ocular movement by the inferior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031742 ; owl:annotatedTarget "Reduced movement by the inferior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031743 ; owl:annotatedTarget "Excessive action of the inferior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031745 ; owl:annotatedTarget "Excessive action of the superior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031746 ; owl:annotatedTarget "Mechanical limitation of the range of movement of the superior rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031747 ; owl:annotatedTarget "Reduced movement of the superior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031748 ; owl:annotatedTarget "A functional anomaly of the superior or inferior rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031750 ; owl:annotatedTarget "Decreased strength (ability to move) of the lateral rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031751 ; owl:annotatedTarget "Reduced movement of the lateral rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "PMID:22127808" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031753 ; owl:annotatedTarget "Decreased strength of the medial rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031755 ; owl:annotatedTarget "A functional anomaly of a vertical or horizontal rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031756 ; owl:annotatedTarget "Reduced movement of the medial rectus muscle which improves on testing ductions, typically associated with neurogenic palsy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031757 ; owl:annotatedTarget "Mechanical limitation of the range of movement of the medial rectus muscle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031759 ; owl:annotatedTarget "A form of convergent strabismus (esotropia) in which the deviation is present under all conditions (ie at all distances and at all times)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031760 ; owl:annotatedTarget "A form of esotropia in which the angle of deviation is not affected by accommodative effort." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031761 ; owl:annotatedTarget "Constant esotropia occurring before 6 months of age. It is typically associated with a large angle of deviation, alternating fixation (therefore low risk of amblyopia) and poor potential for binocular single vision. Other features that might be present in individuals with infantile (constant) esotropia include latent nystagmus or manifest latent nystagmus, dissociated vertical divergence, cyclotropia, abnormal head posture, limited abduction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031762 ; owl:annotatedTarget "An intermittent esotropia where binocular single vision is present on near fixation and an esotropia on distance fixation. Often associated with myopia and aging." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031763 ; owl:annotatedTarget "Convergent strabismus in which normal binocular single vision is alternating with large angle esotropia in rhythmic cycle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031764 ; owl:annotatedTarget "Esotropia in which normal binocular single vision is present for all distances when the hypermetropic refractive error is corrected. Esotropia is present for near and distance on accommodation without correction." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "PMID:22277286" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031765 ; owl:annotatedTarget "A form of constant esotropia in which the angle of deviation is partially affected by accommodative effort. Typically there is esotropia at near and distance with hypermetropic correction and the angle of deviation increases without glasses." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031766 ; owl:annotatedTarget "An intermittent esotropia with binocular single vision present at distance fixation but esotropia on accommodation for near fixation. Usually associated with hypermetropia but patients can be emmetropic and rarely myopic. Associated with a high accommodative convergence/accommodation (AC/A) ratio." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031767 ; owl:annotatedTarget "Esotropia in a patient who has previously had exotropia or exophoria; may be constant or intermittent and usually follows surgical overcorrection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031768 ; owl:annotatedTarget "Fixation of an object in the area adjacent to the fovea." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031769 ; owl:annotatedTarget "Fixation of an object in a peripheral area of the retina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031770 ; owl:annotatedTarget "A type of epicanthus in which a medial vertical fold is present between upper and lower lids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031771 ; owl:annotatedTarget "A type of epicanthus in which a primarily upper lid fold is present." . [] oboInOwl:hasDbXref "PMID:9848859" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031774 ; owl:annotatedTarget "A funnel-shaped symmetrical enlargement of the origin of the posterior communicating artery at its junction with the internal carotid artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031775 ; owl:annotatedTarget "An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031776 ; owl:annotatedTarget "A form of manifest strabismus (heterotropia) in which the one eye is wheel rotated so that the upper end of its vertical axis is nasal (incyclotropia) or temporal (excyclotropia)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "PMID:22344644" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031777 ; owl:annotatedTarget "A form of latent strabismus (heterophoria) in which the occluded eye wheel-rotates on dissociation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031778 ; owl:annotatedTarget "A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated inward (medially) to each other." . [] oboInOwl:hasDbXref "PMID:27721930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031780 ; owl:annotatedTarget "A type of ascites in which there are large numbers of eosinophils in the ascitis fluid." . [] oboInOwl:hasDbXref , "PMID:9602615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031781 ; owl:annotatedTarget "A type of microtropia with no manifest movement on cover test, the eccentric fixation point coinciding with the angle of ARC." . [] oboInOwl:hasDbXref , "PMID:9602615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031782 ; owl:annotatedTarget "A type of microtropia in which the manifest movement is demonstrated on the cover-uncover test." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "Reaxys:1720252" . [] oboInOwl:hasDbXref , "PMID:24551710" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031783 ; owl:annotatedTarget "A developmental defect in which the coronary sinus fails to form." . [] oboInOwl:hasDbXref "MP:0009867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031784 ; owl:annotatedTarget "Any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031786 ; owl:annotatedTarget "Transient eyelid retraction during refixation from down to straight ahead." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031787 ; owl:annotatedTarget "Astigmatism in which the refractive power of the vertical meridian is the greatest." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031788 ; owl:annotatedTarget "Refractive error in which the vertical meridian is relatively hypermetropic and the horizontal meridian is relatively myopic (or ocular astigmatism in which the refractive power of the horizontal meridian is the greatest)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031790 ; owl:annotatedTarget "A type of astigmatism in which an unequal curvature of the cornea and some cases additionally of the lens causes one meridian of the eye to be hyperopic (farsighted) and a second meridian that is perpendicular to the first to be myopic (nearsighted)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "(2R)-2-hydroxypropanoic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031793 ; owl:annotatedTarget "An increased concentration of leptin in the blood." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "(-)-lactic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031798 ; owl:annotatedTarget "Increased circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031799 ; owl:annotatedTarget "Concentration of apolipoprotein A-I below the lower limit of normal. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in plasma. Defects in this gene are associated with HDL deficiencies, including Tangier disease." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031800 ; owl:annotatedTarget "An increased concentration in blood of apolipoprotein A-II, a major component of HDL particles, associated with triglyceride and glucose metabolism." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "(R)-(-)-lactic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "D-2-Hydroxypropanoic acid" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031803 ; owl:annotatedTarget "Fundus haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031804 ; owl:annotatedTarget "Premacular haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031805 ; owl:annotatedTarget "A subtype of fundus hemorrhage occurring within the neurosensory retina. Intraretinal haemorrhages may be 'dot' or' blot' shaped or flame shaped depending upon their depth within the retina." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031805 ; owl:annotatedTarget "Intraretinal haemorrhage" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "D-2-Hydroxypropionic acid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "D-Lactic acid" . [] oboInOwl:hasDbXref , "PMID:22075011", "PMID:22629539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031809 ; owl:annotatedTarget "Shortening of the fourth and fifth metacarpals when the fist is clenched." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031809 ; owl:annotatedTarget "Knuckle dimple" . [] oboInOwl:hasDbXref , "PMID:8027366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031810 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react to gangliosides." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031811 ; owl:annotatedTarget "Presence of conjugated bilirubin in the urine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "D-Milchsaeure" . [] oboInOwl:hasDbXref , "PMID:27377945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031812 ; owl:annotatedTarget "Presence of nitrites in the urine." . [] oboInOwl:hasDbXref "PMID:21922029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031813 ; owl:annotatedTarget "An excess of eosinophilic cells in colonic tissue, i.e., eosinophilic infiltration in the colon." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "D-lactic acid" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:1302009" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031817 ; owl:annotatedTarget "An abnormally decreased concentration of parathyroid hormone." . [] oboInOwl:hasDbXref , "PMID:12872269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031819 ; owl:annotatedTarget "Increased waist-to-hip ratio (WHR) is a measurement above the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:12872269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031820 ; owl:annotatedTarget "Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031821 ; owl:annotatedTarget "Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42111 ; owl:annotatedTarget "LACTIC ACID" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031822 ; owl:annotatedTarget "Abnormally increased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_sjwang" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031823 ; owl:annotatedTarget "Abnormally decreased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate." . [] oboInOwl:hasDbXref , "PMID:25009756" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031824 ; owl:annotatedTarget "Liver mast cell infiltration." . [] oboInOwl:hasDbXref "PMID:23625316", "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031825 ; owl:annotatedTarget "Freezing of gait is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk." . [] oboInOwl:hasDbXref "PMID:12531937", "PMID:24785227" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031827 ; owl:annotatedTarget "Lack of contraction of abdominal muscles in the quadrant of the abdomen that is stimulated by scraping the skin tangential to or toward the umbilicus." . [] oboInOwl:hasDbXref "PMID:12891505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031829 ; owl:annotatedTarget "Lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex." . [] oboInOwl:hasDbXref "PMID:24311926" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031830 ; owl:annotatedTarget "A pinguecula is a yellowish to brown protruding lesion in the conjunctiva that is easily seen on the nasal and temporal sides of the cornea." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:16518702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031831 ; owl:annotatedTarget "A reduced concentration of zinc in the blood." . [] oboInOwl:hasDbXref "MP:0010635", "PMID:26467877" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031834 ; owl:annotatedTarget "Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:25276767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031835 ; owl:annotatedTarget "An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031836 ; owl:annotatedTarget "Increased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:25276767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031837 ; owl:annotatedTarget "Decreased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." . [] oboInOwl:hasDbXref "MP:0004038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031842 ; owl:annotatedTarget "Dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma." . [] oboInOwl:hasDbXref "PMID:25850732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031843 ; owl:annotatedTarget "Abnormal slowness of thought processes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031843 ; owl:annotatedTarget "Mental slowness" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031843 ; owl:annotatedTarget "Slowed thinking" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031843 ; owl:annotatedTarget "Slowness of thought" . [] oboInOwl:hasDbXref "PMID:25834762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031844 ; owl:annotatedTarget "A sense of intense joy or happiness that is beyond what would be expected under the given circumstances." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031847 ; owl:annotatedTarget "Reduced ability to walk (ambulate) in a backwards direction." . [] oboInOwl:hasDbXref "PMID:24746291" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031848 ; owl:annotatedTarget "An abnormality of gait that can be observed in individuals with dystonic posture in which the individual walks with an extended trunk and flexed arms, while strutting on the toes without the heels touching the floor." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031850 ; owl:annotatedTarget "Abnormal Hct" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031851 ; owl:annotatedTarget "Reduced Hct" . [] oboInOwl:hasDbXref "PMID:21731561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031853 ; owl:annotatedTarget "Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other." . [] oboInOwl:hasDbXref "PMID:21731561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031854 ; owl:annotatedTarget "A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures." . [] oboInOwl:hasDbXref "PMID:21731561" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031855 ; owl:annotatedTarget "A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "Beilstein:1720251" . [] oboInOwl:hasDbXref "PMID:21956287" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031856 ; owl:annotatedTarget "An abnormal gait characterized by toe walking, stiff legs, and skipping. The gait pattern has some resemblance to cock-walk gait, but affected individuals are able to improve their dystonic gait by walking backward." . [] oboInOwl:hasDbXref "PMID:28665309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031857 ; owl:annotatedTarget "Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus." . [] oboInOwl:hasDbXref "PMID:25368745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031858 ; owl:annotatedTarget "Longitudinal grooves in the surface of the esophagus arranged in a longitudinal fashion (from top to bottom of the esophagus)." . [] oboInOwl:hasDbXref "PMID:8598068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031860 ; owl:annotatedTarget "Any abnormality in the variability of the time interval between successive heartbeats." . [] oboInOwl:hasDbXref , "PMID:8598068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031861 ; owl:annotatedTarget "Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle." . [] oboInOwl:hasDbXref , "PMID:8598068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031862 ; owl:annotatedTarget "Increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031865 ; owl:annotatedTarget "Any functional anomaly of the liver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031866 ; owl:annotatedTarget "Clasp-knife phenomonen refers to increased muscle tone while bending or stretching a limb, whereby there is a sudden relaxation (decrease in resistance) as the muscle continues to be streched. This phenomenon has been likened to opening a clasp knife." . [] oboInOwl:hasDbXref , "PMID:24607223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031868 ; owl:annotatedTarget "Difficulty reaching to visually guided goals in peripheral vision, with the deficit leaves voluntary eye movements largely unaffected." . [] oboInOwl:hasDbXref , "PMID:23242558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031870 ; owl:annotatedTarget "An elevated concentration of phosphohydroxylysine in the urine." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "CAS:79-33-4" . [] oboInOwl:hasDbXref "PMID:29449841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031871 ; owl:annotatedTarget "Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis." . [] oboInOwl:hasDbXref , "PMID:15816828" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031872 ; owl:annotatedTarget "Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still not completely understood, although most studies point toward an active role in receptor-mediated endocytosis and participation in the antigen-processing/presenting function of LC. This feature refers to the absence of BG in LC, a feature that can be documented by means of electron microscopy." . [] oboInOwl:hasDbXref , "PMID:16450011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031875 ; owl:annotatedTarget "Any deviation from the normal concentration of hepcidin in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:16450011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031876 ; owl:annotatedTarget "Concentration of hepcidin in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref , "PMID:16450011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031877 ; owl:annotatedTarget "Concentration of hepcidin in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref , "PMID:22043168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031878 ; owl:annotatedTarget "Small hands and feet in proportion to the rest of the body." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "CAS:79-33-4" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031880 ; owl:annotatedTarget "Abnormally lax eyelid associated with tissue relaxation; it can be demonstrated by the eyelid distraction test and/or the eyelid snap test." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031881 ; owl:annotatedTarget "A form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031882 ; owl:annotatedTarget "A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031883 ; owl:annotatedTarget "An elevated concentration of proinsulin (the prohormone precursor to insulin) to mature insulin in the circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031885 ; owl:annotatedTarget "Abnormally high glucose concentration in the cerebrospinal fluid." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031886 ; owl:annotatedTarget "Any deviation from the normal concentration of low-density lipoprotein cholesterol in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031886 ; owl:annotatedTarget "Abnormal LDL-C concentration" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "CAS:79-33-4" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031886 ; owl:annotatedTarget "Abnormal LDL-C level" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031886 ; owl:annotatedTarget "Abnormal LDLc concentration" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "Gmelin:362717" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:21996028" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22336740" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22367529" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031891 ; owl:annotatedTarget "Abnormal reduction in the count of eosinophils in the blood per volume." . [] oboInOwl:hasDbXref , "PMID:16739263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031898 ; owl:annotatedTarget "Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells." . [] oboInOwl:hasDbXref "PMID:16372800", "PMID:19522836", "PMID:25169217", "PMID:27749843", "PMID:3295549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031901 ; owl:annotatedTarget "An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:26045617", "PMID:29494512" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031903 ; owl:annotatedTarget "Any deviation from the normal circulating concentration of selenium." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22424924" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031905 ; owl:annotatedTarget "An abnormally elevated total hemolytic complement activity in the circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031906 ; owl:annotatedTarget "An abnormally reduced total hemolytic complement activity in the circulation." . [] oboInOwl:hasDbXref , "PMID:30579751" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031907 ; owl:annotatedTarget "The presence of M2 anti-mitochondrial antibody (immunoglobulins) in the serum." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031907 ; owl:annotatedTarget "AMA-M2 positive" . [] oboInOwl:hasDbXref , "PMID:29403348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031908 ; owl:annotatedTarget "Abnormally small sized handwriting defined formally as an impairment of a fine motor skill manifesting mainly as a progressive or stable reduction in amplitude during a writing task." . [] oboInOwl:hasDbXref "PMID:28811816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031909 ; owl:annotatedTarget "A uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22443585" . [] oboInOwl:hasDbXref , "PMID:10653422", "PMID:2256843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031912 ; owl:annotatedTarget "Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031912 ; owl:annotatedTarget "Trigeminal anaesthesia" . [] oboInOwl:hasDbXref , "PMID:22451504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031913 ; owl:annotatedTarget "Rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis." . [] oboInOwl:hasDbXref "NCIT:C4862", "PMID:27858568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031918 ; owl:annotatedTarget "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031918 ; owl:annotatedTarget "Ovarian sex cord-stromal tumour" . [] oboInOwl:hasDbXref "NCIT:C7289", "PMID:25788847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031919 ; owl:annotatedTarget "Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occuring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031919 ; owl:annotatedTarget "Juvenile type ovarian granulosa cell tumour" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22461545" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031919 ; owl:annotatedTarget "Ovarian juvenile granulosa cell tumour" . [] oboInOwl:hasDbXref "NCIT:C8403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031920 ; owl:annotatedTarget "An aggressive granulosa cell tumor that arises from the ovary." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031920 ; owl:annotatedTarget "Malignant ovarian granulosa cell tumour" . [] oboInOwl:hasDbXref "PMID:29491286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031921 ; owl:annotatedTarget "Pain of the gastrocnemius muscle." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031921 ; owl:annotatedTarget "Calf muscle pain" . [] oboInOwl:hasDbXref "PMID:15378279", "PMID:21475502" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031922 ; owl:annotatedTarget "The renal arteries carry blood from the aorta to the kidney; normally one renal artery is present on each side of the body. Renal artery duplication refers to the presence of two rather than one renal artery on a given side of the body." . [] oboInOwl:hasDbXref "PMID:29479403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031923 ; owl:annotatedTarget "Accumulation of blood in the vagina usually due to vaginal obstruction." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031923 ; owl:annotatedTarget "Haematocolpos" . [] oboInOwl:hasDbXref "PMID:16935918", "PMID:26131871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031924 ; owl:annotatedTarget "The presence of linear erythematous palpable cords, often on the lateral trunk." . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031925 ; owl:annotatedTarget "A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22534372" . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031926 ; owl:annotatedTarget "A type of rosette in which the central lumen or hub is filled with fiber-like processes." . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031927 ; owl:annotatedTarget "The tumor cells that form the Flexner-Wintersteiner rosette circumscribe a central lumen that contains small cytoplasmic extensions of the encircling cells; however, unlike the center of the Homer Wright rosette, the central lumen does not contain the fiber-rich neuropil." . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031928 ; owl:annotatedTarget "A type of rosette in which a halo of cells surrounds an empty lumen." . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031929 ; owl:annotatedTarget "A type of rosette in which a spoke-wheel arrangement of cells with tapered cellular processes radiates around a wall of a centrally placed vessel." . [] oboInOwl:hasDbXref "PMID:16551982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031930 ; owl:annotatedTarget "A type of rosette that is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular." . [] oboInOwl:hasDbXref , "PMID:17314191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031931 ; owl:annotatedTarget "Ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behaviour and its occurrence may be favoured by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation." . [] oboInOwl:hasDbXref "PMID:26085759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031932 ; owl:annotatedTarget "Aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left or right ventricular cavity." . [] oboInOwl:hasDbXref "PMID:27525240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031933 ; owl:annotatedTarget "The presence of an extracardiac channel that connects the ascending aorta above the sinotubular junction to the cavity of the right ventricle." . [] oboInOwl:hasDbXref "PMID:13938144" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031935 ; owl:annotatedTarget "Significant luminal narrowing of a long segment of or the entire ascending aorta." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031937 ; owl:annotatedTarget "Tachylogia" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22538963" . [] oboInOwl:hasDbXref "PMID:27485904" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0031939 ; owl:annotatedTarget "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries with location in the conus terminalis." . [] oboInOwl:hasDbXref "PMID:11796904" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031941 ; owl:annotatedTarget "Any structural anomaly of the portal venous sytem, which comprises all of the veins draining the abdominal part of the digestive tract, including the lower esophagus but excluding the lower anal canal. The portal vein conveys blood from viscera and ramifies like an artery at the liver, ending at the sinusoids. Tributaries of the portal vein, which make up the portal venous system, are the splenic, superior mesenteric, left gastric, right gastric, paraumbilical, and cystic veins." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "PMID:22578598" . [] oboInOwl:hasDbXref "PMID:18932274", "PMID:2053351" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031942 ; owl:annotatedTarget "Anomaly where the intestinal and the splenic venous drainage bypass the liver and drain into systemic veins through other possible venous shunts." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031942 ; owl:annotatedTarget "CAPV" . [] oboInOwl:hasDbXref "PMID:17974927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031943 ; owl:annotatedTarget "A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria." . [] oboInOwl:hasDbXref "PMID:23287997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031944 ; owl:annotatedTarget "An increase in the thickness of the pleura, generally related to scarring of the pleural tissue." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "CAS:97-59-6" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "Reaxys:1720251" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "(2S)-2-hydroxypropanoic acid" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0031947 ; owl:annotatedTarget "Jerky movements of the tongue" . [] oboInOwl:hasDbXref "PMID:24663235", "PMID:26991403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031948 ; owl:annotatedTarget "Centrally located corpus callosum hyperintensities said to resemble snowballs upon magnetic resonance imaging (with T2 or Sagittal fluid attenuated inversion recovery [FLAIR] sequences). The central location in the callosum makes them pathognomonic for Susac syndrome." . [] oboInOwl:hasDbXref "PMID:26424818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031949 ; owl:annotatedTarget "An increased susceptibility to bacterial upper respiratory tract infections as manifested by a history of recurrent bacterial upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031949 ; owl:annotatedTarget "Recurrent bacterial URI" . [] oboInOwl:hasDbXref "PMID:26666486", "PMID:8697837" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031950 ; owl:annotatedTarget "Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing." . [] oboInOwl:hasDbXref "PMID:22334817", "PMID:23385697", "PMID:25941204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031951 ; owl:annotatedTarget "Seizures that occur while the affected individual is sleeping." . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031952 ; owl:annotatedTarget "Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine." . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031954 ; owl:annotatedTarget "Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients." . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031955 ; owl:annotatedTarget "To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "(+)-lactic acid" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031956 ; owl:annotatedTarget "Elevated serum AST" . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031957 ; owl:annotatedTarget "Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster." . [] oboInOwl:hasDbXref "PMID:27770207" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031958 ; owl:annotatedTarget "A type of spastic gait in which the legs are usually slightly bent at the hip and in an adducted position. The knees are extended or slightly bent and the feet are in a plantar flexion position. This posture requires circumduction of the legs during walking. The gait may appear stiff (spastic gait disorder) or stiff as well as insecure (spastic ataxic gait disorder). In spastic paraparetic gait, each leg appears to be dragged forward. If the muscle tone in the adductors is marked, the resulting gait disorder is referred to as scissor gait." . [] oboInOwl:hasDbXref "PMID:17699401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031961 ; owl:annotatedTarget "Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration." . [] oboInOwl:hasDbXref "PMID:17699401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031962 ; owl:annotatedTarget "An abnormally high value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration)." . [] oboInOwl:hasDbXref "PMID:17699401" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031963 ; owl:annotatedTarget "An abnormally low value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration)." . [] oboInOwl:hasDbXref "PMID:18366115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031964 ; owl:annotatedTarget "An abnormally high concentration in the circulation of alanine aminotransferase (ALT)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031964 ; owl:annotatedTarget "Elevated serum ALT" . [] oboInOwl:hasDbXref "PMID:27867951", "PMID:28683798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031965 ; owl:annotatedTarget "Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031969 ; owl:annotatedTarget "Reduced BUN" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "(S)-(+)-lactic acid" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031970 ; owl:annotatedTarget "Abnormal BUN concentration" . [] oboInOwl:hasDbXref , "PMID:25129067", "PMID:9203495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031971 ; owl:annotatedTarget "A localized hypertrophy of the subaortic segment of the ventricular septum has been frequently described in elderly persons, and variously termed subaortic ventricular septal bulge (VSB), sigmoid-shaped septum, localized or discrete upper septal hypertrophy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031972 ; owl:annotatedTarget "Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031973 ; owl:annotatedTarget "An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disc." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031974 ; owl:annotatedTarget "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.6 (The normal cup-to-disc ratio is 0.3)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031975 ; owl:annotatedTarget "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.7 (The normal cup-to-disc ratio is 0.3)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031976 ; owl:annotatedTarget "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.8 (The normal cup-to-disc ratio is 0.3)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031977 ; owl:annotatedTarget "Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.9 (The normal cup-to-disc ratio is 0.3)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031978 ; owl:annotatedTarget "Ratio of the height of the cup of the optic nerve head to the height of the disc is 1.0 (The normal cup-to-disc ratio is 0.3)." . [] oboInOwl:hasDbXref "PMID:2031609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031981 ; owl:annotatedTarget "An increased concentration of glycolate in the urine." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "(S)-2-hydroxypropanoic acid" . [] oboInOwl:hasDbXref "PMID:21960934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031984 ; owl:annotatedTarget "A piece of food that has gotten stuck in the esophagus and prevents further swallowing." . [] oboInOwl:hasDbXref "PMID:22919257" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031985 ; owl:annotatedTarget "An exudate is a mass of fluid and cells that has seeped out of blood vessels or an organ, usually related to inflammation. In the esophagus, exudates usually present as whitish plagues on the surface of the esophageal mucosa." . [] oboInOwl:hasDbXref "PMID:21339907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031986 ; owl:annotatedTarget "Irregular, small-amplitude myoclonic movements of the hands and/or fingers on keeping outstretched posture (jerky postural tremor). Polyminimyoclonus is stimulus-sensitive and accentuated during voluntary movements. A cortical origin can be demonstrated by back-averaging techniques, and somatosensory evoked potentials (SSEPs) are sometimes giant." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "(S)-2-hydroxypropionic acid" . [] oboInOwl:hasDbXref "PMID:26386541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031987 ; owl:annotatedTarget "Being unable to focus one's attention or mental effort on a particular object or activity." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031987 ; owl:annotatedTarget "Concentration problems" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031987 ; owl:annotatedTarget "Lack of concentration" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0031987 ; owl:annotatedTarget "Poor concentration" . [] oboInOwl:hasDbXref "PMID:22970971", "PMID:29443134" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031990 ; owl:annotatedTarget "A contraction of ipsilateral facial muscles subsequent to percussion over the facial nerve." . [] oboInOwl:hasDbXref "PMID:10222355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031991 ; owl:annotatedTarget "An increased concentration of beta-1-galactosyl-O-hydroxylysine (Gal-Hyl) in the urine. This is a biochemical marker of bone resorption." . [] oboInOwl:hasDbXref , "PMID:23109785", "PMID:8685759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031992 ; owl:annotatedTarget "Apical hypertrophic cardiomyopathy (AHCM) is diastolic dysfunction due to abnormal stiffness of the left ventricle during diastole, with resultant impaired ventricular filling. In AHCM thickened apical segments produce a crowded, spade-shaped, small apical cavity." . [] oboInOwl:hasDbXref "PMID:11813951", "PMID:20229121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031993 ; owl:annotatedTarget "A Hoffmann test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031994 ; owl:annotatedTarget "Bronchial breath sounds contain much higher frequency components than normal breath sounds due to alteration of the low pass filtering function of the alveoli, as occurs in consolidation. It is loud, hollow, and high pitch. Expiratory phase is longer than inspiratory phase with the inspiratory-expiratory ratio (I:E) changing from normal 3:1 to 1:2. There is distinct pause between inspiration and expiration due to absent alveolar phase. It is associated with whispering pectoriloquy." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031995 ; owl:annotatedTarget "Squawks are short inspiratory wheezes of less than 200 ms duration and are also known as squeaks. Acoustic analysis shows the fundamental frequency varying between 200 and 300 Hz. Squawks usually occur in late inspiration and are often preceded by late inspiratory crackles." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "L-(+)-alpha-hydroxypropionic acid" . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031996 ; owl:annotatedTarget "Crackles that are heard during the inspiratory phase." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031997 ; owl:annotatedTarget "Crackles that appear at the beginning of inspiration and end before mid-inspiration." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031998 ; owl:annotatedTarget "Crackles that appear any time after the beginning of inspiration and last till the end of inspiration." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0031999 ; owl:annotatedTarget "Crackles that occur during expiration." . [] oboInOwl:hasDbXref "PMID:26229557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032000 ; owl:annotatedTarget "An abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles" . [] oboInOwl:hasDbXref "PMID:18613989", "PMID:29967083" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032002 ; owl:annotatedTarget "An abnormal orange color of urine." . [] oboInOwl:hasDbXref "PMID:28413291" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032003 ; owl:annotatedTarget "An abnormal green color of urine." . [] oboInOwl:hasDbXref "PMID:11784827", "PMID:4031909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032005 ; owl:annotatedTarget "Hemidystonia refers to dystonia which involves the ipsilateral face, arm, and leg." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "L-(+)-lactic acid" . [] oboInOwl:hasDbXref "PMID:12192848" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032007 ; owl:annotatedTarget "A softening and breaking down of skin resulting from prolonged exposure to moisture. Macerated skin becomes soft and wrinkly and takes on a whitish hue." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "L-Lactic acid" . [] oboInOwl:hasDbXref , "PMID:24468004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032008 ; owl:annotatedTarget "The release of fat globules into the venous circulation, thereby blocking blood circulation to the lung." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032009 ; owl:annotatedTarget "Constant exotropia occurring before 6 months of age.; often associated with a large angle of deviation and ocular/CNS abnormalities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032010 ; owl:annotatedTarget "Constant exotropia for near and distance, presenting after 6 months of age." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032012 ; owl:annotatedTarget "Manifest deviation of the visual axes not controlled by fusion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032014 ; owl:annotatedTarget "Inaccurate saccades (rapid movement of the eye between fixation points) in the vertical direction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032015 ; owl:annotatedTarget "Inaccurate saccades (rapid movement of the eye between fixation points) in the horizontal direction." . [] oboInOwl:hasDbXref , "PMID:23741092", "PMID:29146301" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032017 ; owl:annotatedTarget "An increased proportion of eosinophils in sputum in the differentiated cell count." . [] oboInOwl:hasDbXref , "PMID:25494723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032018 ; owl:annotatedTarget "A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially." . [] oboInOwl:hasDbXref , "PMID:24424174", "PMID:24803842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032019 ; owl:annotatedTarget "Eosinophil infiltration of skeletal muscle." . [] oboInOwl:hasDbXref "PMID:15857336", "PMID:28829677" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032020 ; owl:annotatedTarget "Transmural inflammation of the bladder predominantly with eosinophils, associated with fibrosis with or without muscle necrosis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_422 ; owl:annotatedTarget "L-Milchsaeure" . [] oboInOwl:hasDbXref , "PMID:20457690", "PMID:7835024" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032021 ; owl:annotatedTarget "Cellular infiltration of the liver parenchyma with a preponderance of eosinophils." . [] oboInOwl:hasDbXref "PMID:23730155", "PMID:6724778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032022 ; owl:annotatedTarget "Presence of abnormally increased amounts of intraepidermal inflammatory cells with a predominance of eosinophils." . [] oboInOwl:hasDbXref "PMID:27872806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032023 ; owl:annotatedTarget "Cellular infiltrate confirmed by a cellular infiltrate comprised of mainly eosinophils in the gallbladder wall on histological examination." . [] oboInOwl:hasDbXref "PMID:28670609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032024 ; owl:annotatedTarget "An erosion of the mucous membrane in a portion of the ileum." . [] oboInOwl:hasDbXref "PMID:24507836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032025 ; owl:annotatedTarget "A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs." . [] oboInOwl:hasDbXref "PMID:20652064", "PMID:28116317" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032026 ; owl:annotatedTarget "Circumscribed area of flaccid skin due to the loss of elastic tissue in the dermis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032027 ; owl:annotatedTarget "Yellow, white or greyish lesions in the retina that are well-defined/distinct, individual and mostly uniform in size." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032028 ; owl:annotatedTarget "Yellow, white or greyish lesions in the macula that are well-defined/distinct, individual and mostly uniform in size." . [] oboInOwl:hasDbXref , "PMID:26139650" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032029 ; owl:annotatedTarget "Excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032030 ; owl:annotatedTarget "Laxity of the tendon stabilising the lateral aspect of the tarsal plate to the zygomatic bone. This can result in rounded appearence of the lateral canthus. Also, when the eyelid is pulled medially, more than 2 mm movement of the canthal angle may be observed." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "CAS:97-59-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032031 ; owl:annotatedTarget "Laxity of the tendon stabilising the medial aspect of the tarsal plate to the anterior and posterior lacrimal crests. This may lead to more than 2mm movement of the punctum when the eyelid is pulled laterally." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032032 ; owl:annotatedTarget "Abnormally lax eyelid associated with tissue relaxation, predominantly in the horizontal plane. It can be demonstrated by the horizontal eyelid distraction test (e.g. by pulling the eyelid medially and laterally). Medial and/or lateral canthal tendon laxity are often present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032033 ; owl:annotatedTarget "Abnormally lax eyelid associated with tissue relaxation, predominantly in the vertical plane. It can be demonstrated by vertical lid pull. Loosening of vertical stabilising structures (e.g. lower lid retractors) or tarsal atrophy are often present." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032034 ; owl:annotatedTarget "Abnormally lax upper eyelid associated with tissue relaxation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032035 ; owl:annotatedTarget "Abnormally lax lower eyelid associated with tissue relaxation." . [] oboInOwl:hasDbXref , "PMID:12809156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032036 ; owl:annotatedTarget "An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target. Contrast-sensitivity measurements differ from acuity measurements; acuity is a measure of the spatial-resolving ability of the visual system under conditions of very high contrast, whereas contrast sensitivity is a measure of the threshold contrast for seeing a target." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "FORMYL GROUP" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "aldehyde group" . [] oboInOwl:hasDbXref "PMID:26628451", "PMID:29749984" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032041 ; owl:annotatedTarget "A small growth on a vocal cord that may appear as pedunculated or sessile and have varying size, shape, and color." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032043 ; owl:annotatedTarget "Painful swallowing" . [] oboInOwl:hasDbXref "PMID:16581292" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032044 ; owl:annotatedTarget "A reduction in the ability to maintain sustained attention characterized by reduced alertness." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "carbaldehyde" . [] oboInOwl:hasDbXref "PMID:12707084" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032046 ; owl:annotatedTarget "A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032047 ; owl:annotatedTarget "A type of focal cortical dysplasia that is characterized by abnormal cortical layering." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032048 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032049 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032050 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032051 ; owl:annotatedTarget "A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032052 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032053 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032054 ; owl:annotatedTarget "A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032055 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organisation (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (also known as Ammon's horn sclerosis)." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "formyl" . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032056 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032057 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis)." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032058 ; owl:annotatedTarget "A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections." . [] oboInOwl:hasDbXref , "PMID:21219302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032059 ; owl:annotatedTarget "A malformation of cortical development characterized by mild abnormalities of the cortex: excessive heterotopic neurons in Layer 1 or microscopic neuronal clusters or excess of single neurons of normal morphology in deep white matter." . [] oboInOwl:hasDbXref "NCIT:C4298", "PMID:25484503", "PMID:25927152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032060 ; owl:annotatedTarget "A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area." . [] oboInOwl:hasDbXref "PMID:20538328" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032061 ; owl:annotatedTarget "A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter." . [] oboInOwl:hasDbXref "PMID:22560400" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032062 ; owl:annotatedTarget "Vomiting-induced mucosal laceration at the esophago-gastric junction." . [] oboInOwl:hasDbXref "PMID:17868858", "PMID:23964139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032064 ; owl:annotatedTarget "Eosinophilic infiltration of one or more gastrointestinal organs. Gastrointestinal eosinophilia is a broad term for abnormal eosinophil accumulation in the GI tract, involving many different disease identities. These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in HES and all gastrointestinal eosinophilic states associated with known causes. Each of these diseases has its unique features but there is no absolute boundary between them." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032064 ; owl:annotatedTarget "GI eosinophilia" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032065 ; owl:annotatedTarget "Abnormal serum HCO3 concentration" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "-CH(O)" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032066 ; owl:annotatedTarget "Decreased serum HCO3 concentration" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032067 ; owl:annotatedTarget "Elevated serum HCO3 concentration" . [] oboInOwl:hasDbXref "PMID:8126784" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032068 ; owl:annotatedTarget "An increased amount of urinary mucus. A small amount of mucus is produced by mucous membrane epithelial cells of the urinary tract. An increased amount of mucus can be detected upon urinalysis or other assays and may indicate conditions such as urinary tract infection, urinary tract reconstruction involving the use of bowel segments, or contamination of the urine sample prior to urinalysis." . [] oboInOwl:hasDbXref , "PMID:21196203", "PMID:33144894", "PMID:33999913", "PMID:34634575" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032069 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032069 ; owl:annotatedTarget "TgAbs" . [] oboInOwl:hasDbXref "PMID:17374867" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032070 ; owl:annotatedTarget "Contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis." . [] oboInOwl:hasDbXref "PMID:19618037", "PMID:21428117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032071 ; owl:annotatedTarget "The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia." . [] oboInOwl:hasDbXref "PMID:25102502", "PMID:26137182" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032072 ; owl:annotatedTarget "A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "-CHO" . [] oboInOwl:hasDbXref , "PMID:18398855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032075 ; owl:annotatedTarget "Fusion of the pancreatic tail and spleen." . [] oboInOwl:hasDbXref "PMID:28537045" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032077 ; owl:annotatedTarget "An abnormal narrowing of the urethral opening (meatus) of the penis." . [] oboInOwl:hasDbXref "PMID:8267010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032078 ; owl:annotatedTarget "A phalangeal malformation that is termed angel-shaped phalanx (ASP), because of its resemblance to the angels used for decoration of Christmas trees. The various components of an angel-shaped phalanx are: diaphyseal cuff (wings), surrounding a meta-diaphyseal core (body), which may appear empty or structured with a cone-shaped epiphysis (skirt) and pseudoepiphysis (head)." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032079 ; owl:annotatedTarget "Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032081 ; owl:annotatedTarget "A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix does not significantly alter the arrangement of the lamellar units." . [] oboInOwl:hasDbXref "CBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "Fo" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032082 ; owl:annotatedTarget "A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix alters the arrangement of the lamellar units to varying degrees." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032083 ; owl:annotatedTarget "Loss and/or fragmentation of elastic fibers of the media of the aorta creating increasingly extended translamellar spaces, with absence of elastic fibers, and increased gaps in elastic fiber lamellae as identified on a stain for elastic fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032083 ; owl:annotatedTarget "Aortic elastic fibre fragmentation" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032084 ; owl:annotatedTarget "A thinning out of elastic fibers of the media of the aorta that creates widening of intralamellar spaces, as identified on a stain for elastic fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032084 ; owl:annotatedTarget "Aortic elastic fibre thinning" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032085 ; owl:annotatedTarget "Nonparallel arrangement/disarray of elastic fibers of the media of the aorta as identified on a stain for elastic fibers." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032085 ; owl:annotatedTarget "Aortic elastic fibre disorganisation" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032086 ; owl:annotatedTarget "A region of the aortic media in which smooth muscle cell nuclei, involving multiple lamellae, are not clearly identifiable on an hematoxylin and eosin stain." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032087 ; owl:annotatedTarget "Architecturally, a compaction of aortic medial elastic fibers that creates thinning of the lamellar unit secondary to a band-like smooth muscle cell loss identified using a stain for elastic fibers." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032088 ; owl:annotatedTarget "Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "H-CO-" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032088 ; owl:annotatedTarget "Aortic smooth muscle cell disorganisation" . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032089 ; owl:annotatedTarget "An increase in collagen fibers creating areas of substitutive fibrosis or a widening of intralamellar spaces in the media of the aorta. This can be seen in conjunction with a loss to varying degrees of parallel arrangement of the elastic lamellae (or lamellar units)." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032090 ; owl:annotatedTarget "A type of aortic medial fibrosis in which the increase in collagen does not significantly alter the arrangement of the lamellar units." . [] oboInOwl:hasDbXref "PMID:27031798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032091 ; owl:annotatedTarget "A type of aortic medial fibrosis in which the increase in collagen is more scar-like, altering the arrangement of the lamellar units." . [] oboInOwl:hasDbXref "PMID:29262119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032092 ; owl:annotatedTarget "Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle." . [] oboInOwl:hasDbXref "PMID:28591049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032094 ; owl:annotatedTarget "An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_42485 ; owl:annotatedTarget "methanoyl" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "CAS:97-59-6" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "HYDROXY GROUP" . [] oboInOwl:hasDbXref "PMID:29382362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032097 ; owl:annotatedTarget "An elevation above the normal concentration of manganese in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "hydroxy" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "hydroxy group" . [] oboInOwl:hasDbXref "PMID:27833976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032099 ; owl:annotatedTarget "The presence of radial grooves in the skin surrounding the mouth (see Figure 4 of PMID:27833976)." . [] oboInOwl:hasDbXref "PMID:7299406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032100 ; owl:annotatedTarget "The doll's eye reflex (also known as oculocephalic reflex) is a test of brain function that is performed in comatose patients by elevating the head roughly 30 degrees and rapidly rotating the head from side to side with the eyes kept open. A normal response is for the eyes to move in the opposite direction. If the eyes do not move in the opposite direction this may indicate severe brain damage." . [] oboInOwl:hasDbXref "PMID:22052638" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032101 ; owl:annotatedTarget "A type of infection that is regarded as a sign of a pathological susceptibility to infection. There are five general subtypes. (i) Opportunistic infection, meaning infection by a pathogen that is not normally able to cause infection in a healthy host (e.g., pneumonia by Pneumocystis jirovecii or CMV); (ii) Unusual location (focus) of an infection (e.g., an aspergillus brain abscess); (iii) a protracted course or lack of adequate response to treatment (e.g., chronic rhinosinusitis); (iv) Unusual severity or intensity of an infection; and (v) unusual recurrence of infections." . [] oboInOwl:hasDbXref "PMID:12975201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032102 ; owl:annotatedTarget "Wilson sign is defined as the elicitation of pain by internally rotating the patient's tibia during knee extension between 90 degrees and 30 degrees of flexion and then relieving that pain by externally rotating the tibia." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032104 ; owl:annotatedTarget "An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by an immediate corrective saccade." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032104 ; owl:annotatedTarget "Saccadic oscillations" . [] oboInOwl:hasDbXref "PMID:14681893" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032105 ; owl:annotatedTarget "A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032106 ; owl:annotatedTarget "Yellowing of the whites of the eyes" . [] oboInOwl:hasDbXref , "PMID:26788074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032107 ; owl:annotatedTarget "A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032108 ; owl:annotatedTarget "A mild reduction in the ability to perceive visual contrast characterized by 0.20-0.59 log unit contrast sensitivity loss." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "-OH" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032109 ; owl:annotatedTarget "A moderate reduction in the ability to perceive visual contrast characterized by 0.60-0.99 log unit contrast sensitivity loss." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032110 ; owl:annotatedTarget "A severe reduction in the ability to perceive visual contrast characterized by 1.00 log unit or more contrast sensitivity loss." . [] oboInOwl:hasDbXref "PMID:1911660" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032111 ; owl:annotatedTarget "An abnormality in perception of contrast as measured by the Vistech wall chart sine wave grating test." . [] oboInOwl:hasDbXref , "PMID:16723494" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032112 ; owl:annotatedTarget "An abnormality in perception of contrast as measured by the Pelli-Robson contrast sensitivity chart, which is a large wall-mounted chart, with letters of a fixed size (comprising spatial frequencies appropriate for estimating peak contrast sensitivity) that decrease in contrast." . [] oboInOwl:hasDbXref , , , , , , , ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032113 ; owl:annotatedTarget "A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032114 ; owl:annotatedTarget "An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by a delayed corrective saccade." . [] oboInOwl:hasDbXref , "ISBN:978-0198804550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032116 ; owl:annotatedTarget "Horizontal 10-40 degree excursions from fixation and back again." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032118 ; owl:annotatedTarget "Inflammation of the retina of the eye." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "hydroxyl" . [] oboInOwl:hasDbXref "PMID:12916637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032121 ; owl:annotatedTarget "An abnormal result of a physical examination of the the hand that tests for palsy of the ulnar nerve. This nerve innervates the adductor pollicis and interossei muscles and thereby enables adduction of the thumb and extension of the interphalangeal joint. An abnormal result consists in reduced functionality and muscular weakness in the pinch grip between the thumb and index finger of the affected hand as the patient attempts to pinch a piece of paper that the examiner tries to pull away. The flexor pollicis longus muscle tries to compensate for the weakness by flexing the tip of the thumb at the interphalangeal joint." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43176 ; owl:annotatedTarget "hydroxyl group" . [] oboInOwl:hasDbXref "PMID:28882820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032124 ; owl:annotatedTarget "A deviation of the normal proportion of unswitched memory B cells in circulation relative to the total number of B cells." . [] oboInOwl:hasDbXref "PMID:22566959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032127 ; owl:annotatedTarget "A deviation from the normal proportion of plasmablasts in circulation relative to total number of B cells. Plasmablasts are antibody-secreting cells that originate after infection or vaccination." . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "Drug_Central:4268" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "Gmelin:1998" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydrogen(tetraoxidophosphate)(2-)" . [] oboInOwl:hasDbXref "PMID:26295364" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032130 ; owl:annotatedTarget "Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections." . [] oboInOwl:hasDbXref "PMID:12525422" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032131 ; owl:annotatedTarget "Cervical dysplasia is the precursor to cervical cancer. It is caused by the persistent infection of the human papillomavirus (HPV) into the cervical tissue. Affected cells develop morphologic features with immature basaloid- type squamous cells and mitotic figures in the upper half of the cervical epithelium." . [] oboInOwl:hasDbXref "PMID:17910333" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032132 ; owl:annotatedTarget "A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood." . [] oboInOwl:hasDbXref "PMID:17910333" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032135 ; owl:annotatedTarget "A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydrogenphosphate" . [] oboInOwl:hasDbXref "PMID:26929632" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032138 ; owl:annotatedTarget "A reduction in immunoglobulin levels of the IgG4 subclass in the blood circulation." . [] oboInOwl:hasDbXref "PMID:25309532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032139 ; owl:annotatedTarget "Level of isohemagglutinin reduced below expected concentration. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." . [] oboInOwl:hasDbXref "PMID:26018535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032140 ; owl:annotatedTarget "A reduced ability to synthesize postvaccination antibodies against toxoids and polysaccharides in vaccines, as measured by antibody titer determination following vaccination." . [] oboInOwl:hasDbXref "PMID:18122452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032141 ; owl:annotatedTarget "A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck." . [] oboInOwl:hasDbXref "PMID:10791209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032142 ; owl:annotatedTarget "Fetor hepaticus is the characteristic breath of patients with severe parenchymal liver disease, which has been said to resemble the odor of a mixture of rotten eggs and garlic." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032142 ; owl:annotatedTarget "Foetor hepaticus" . [] oboInOwl:hasDbXref "PMID:25952601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032143 ; owl:annotatedTarget "An intense sensation of burning, scalding, or tingling feeling of the tongue or other regions of the oral mucosa." . [] oboInOwl:hasDbXref "PMID:19564091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032144 ; owl:annotatedTarget "Vomit that has the appearance of coffee grounds, which occurs due to the presence of coagulated blood in the vomit." . [] oboInOwl:hasDbXref "PMID:15215497", "PMID:20301551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032146 ; owl:annotatedTarget "Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032146 ; owl:annotatedTarget "Haemoglobin C" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydrogentetraoxophosphate(2-)" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032146 ; owl:annotatedTarget "HbC haemoglobin" . [] oboInOwl:hasDbXref , "PMID:26419464" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032147 ; owl:annotatedTarget "Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet." . [] oboInOwl:hasDbXref "PMID:26438145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032149 ; owl:annotatedTarget "A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain." . [] oboInOwl:hasDbXref "PMID:29650526" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032150 ; owl:annotatedTarget "Excruciating burning pain in the rectal area that may be triggered by defecation." . [] oboInOwl:hasDbXref "PMID:25527564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032151 ; owl:annotatedTarget "Recurrent episodes of marked eosinophilia that resolve spontaneously." . [] oboInOwl:hasDbXref "PMID:22628989", "PMID:27194977", "PMID:30043128" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032152 ; owl:annotatedTarget "An anomaly of the hair follicles of the skin that typically presents as small, rough, brown folliculocentric papules distributed over characteristic areas of the skin, particularly the outer-upper arms and thighs." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032152 ; owl:annotatedTarget "Chicken skin" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydrogentetraoxophosphate(V)" . [] oboInOwl:hasDbXref "PMID:25346356" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032154 ; owl:annotatedTarget "Oral aphthous ulcers typically present as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032154 ; owl:annotatedTarget "Canker sore" . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:27656858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032156 ; owl:annotatedTarget "Loss of sections of skin either spontaneously or after gentle handling." . [] oboInOwl:hasDbXref "PMID:27532832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032157 ; owl:annotatedTarget "Recurrent episodes of genital herpes, typically characterized by stages of erythema, papules, short-lived vesicles, painful ulcers, and crusts on the skin of the genitals and surrounding area, and that typically resolve over a period of 2 to 3 weeks." . [] oboInOwl:hasDbXref "PMID:29244019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032159 ; owl:annotatedTarget "An infection of the meninges caused by a fungus. Generally, only individuals with deficiencies of the immune system contract fungal meningitis." . [] oboInOwl:hasDbXref "PMID:24715488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032160 ; owl:annotatedTarget "A type of fungal meningitis caused by an encapsulated yeast that belongs to the genus Cryptococcus. Cryptococcus neoformans and Cryptococcus gattii are responsible for the majority of cases of human cryptococcosis." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydroxidotrioxidophosphate(2-)" . [] oboInOwl:hasDbXref "PMID:27927853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032161 ; owl:annotatedTarget "A type of fungal meningitis caused by dissemination of coccidioides to basilar meninges." . [] oboInOwl:hasDbXref "PMID:24740746" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032163 ; owl:annotatedTarget "Molluscum contagiosum is a cutaneous viral infection that is commonly observed in both healthy and immunocompromised children. The infection is caused by a member of the Poxviridae family, the molluscum contagiosum virus. Molluscum contagiosum presents as single or multiple small white or flesh-colored papules that typically have a central umbilication. The central umbilication may be difficult to observe in young children and, instead, may bear an appearance similar to an acneiform eruption. The lesions vary in size (from 1 mm to 1 cm in diameter) and are painless, although a subset of patients report pruritus in the area of infection. On average, 11-20 papules appear on the body during the course of infection and generally remains a self-limiting disease. However, in immunosuppressed patients, molluscum contagiosum can be a severe infection with hundreds of lesions developing on the body. Extensive eruption is indicative of an advanced immunodeficiency state." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "HPO4(2-)" . [] oboInOwl:hasDbXref "PMID:17227114", "PMID:25171710", "PMID:28515588" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032165 ; owl:annotatedTarget "Placental mesenchymal dysplasia is a rare anomaly characterized by placentomegaly, dilatation of chorionic vessels and hydropic stem villi with cistern-like formation. It is often clinically mistaken for a partial hydatidiform mole but there is no trophoblastic proliferation. P57 immunohistochemical expression is discordant, showing a normal positive expression in the cytotrophoblastic cells, and loss of expression in the stromal cells." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032166 ; owl:annotatedTarget "Unusual GI infection" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032167 ; owl:annotatedTarget "C. difficile enteritis" . [] oboInOwl:hasDbXref "PMID:22298971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032168 ; owl:annotatedTarget "An infection of the colon (colitis) by clostridium difficile." . [] oboInOwl:hasDbXref "PMID:21748081", "PMID:23248376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032170 ; owl:annotatedTarget "An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterised by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestions including VZV pneumonia, hepatitis, meningitis, and disseminated varicella." . [] oboInOwl:hasDbXref "PMID:26312141" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032172 ; owl:annotatedTarget "A crescent of air surrounding a soft-tissue mass in a pulmonary cavity and can be seen in both plain X-ray and CT scan." . [] oboInOwl:hasDbXref "PMID:26312141" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032173 ; owl:annotatedTarget "This sign is seen in pneumomediastinum in which air accumulates between the lower border of the heart and the superior part of the diaphragm, which results in complete visualization of the diaphragm in chest X-ray, hence named continuous diaphragm sign." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "HYDROGENPHOSPHATE ION" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032174 ; owl:annotatedTarget "The tree-in-bud pattern represents centrilobular branching structures that resemble a budding tree. The pattern reflects a spectrum of endo- and peribronchiolar disorders, including mucoid impaction, inflammation, and/or fibrosis (See Figure 70 of PMID:18195376)." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032175 ; owl:annotatedTarget "This finding is composed of a ring-shaped opacity representing a dilated bronchus in cross section and a smaller adjacent opacity representing its pulmonary artery, with the combination resembling a signet (or pearl) ring. It is the basic sign of bronchiectasis in pulmonary computed tomography imaging." . [] oboInOwl:hasDbXref "PMID:18195376", "PMID:1994409" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032176 ; owl:annotatedTarget "An apical cap is a caplike lesion at the lung apex, usually caused by intrapulmonary and pleural fibrosis pulling down extrapleural fat or possibly by chronic ischemia resulting in hyaline plaque formation on the visceral pleura. The prevalence increases with age. It can also be seen in hematoma resulting from aortic rupture or in other fluid collection associated with infection or tumor, either outside the parietal pleura or loculated within the pleural space." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032177 ; owl:annotatedTarget "Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia)." . [] oboInOwl:hasDbXref "PMID:1764353", "PMID:24285001" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032178 ; owl:annotatedTarget "A dermatosis characterized by generalized shiny, enamel-like, hyperpigmented scales in an irregular pattern. The scales may peel or desquamate, rather like old, sun-baked blistered paint, often with areas of underlying hypopigmentation. This has led to the terms peeling paint or flaky paint dermatosis (See the Figure in PMID:24285001)." . [] oboInOwl:hasDbXref "PMID:12556263", "PMID:16122505", "PMID:20552624" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032181 ; owl:annotatedTarget "An abnormality of the hepatic veins, which normally drain de-oxygenated blood from the liver into the inferior vena cava, whereby the hepatic veins drain into the left atrium." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "INORGANIC PHOSPHATE GROUP" . [] oboInOwl:hasDbXref "PMID:8450264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032182 ; owl:annotatedTarget "An abnormal proportion of memory T cells compared to the total number of T cells in the blood. Memory T cells have previously encountered and responded to their cognate antigen and upon a repeated encounter with the antigen can mount a faster and stronger response." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "PMID:11157020" . [] oboInOwl:hasDbXref "MolBase" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "[P(OH)O3](2-)" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "[PO3(OH)](2-)" . [] oboInOwl:hasDbXref "PMID:8450264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032183 ; owl:annotatedTarget "An abnormally reduced proportion of memory T cells compared to the total number of T cells in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "hydrogen phosphate" . [] oboInOwl:hasDbXref "PMID:21894250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032185 ; owl:annotatedTarget "The presense of molluscum contagiosum lesions across multiple areas of the body." . [] oboInOwl:hasDbXref "NCIT:C2877" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032186 ; owl:annotatedTarget "A benign or malignant neoplasm that affects the anal canal or anal margin." . [] oboInOwl:hasDbXref "NCIT:C4595", "PMID:28255426" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032187 ; owl:annotatedTarget "Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43474 ; owl:annotatedTarget "phosphate" . [] oboInOwl:hasDbXref , "PMID:9650445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032188 ; owl:annotatedTarget "An increased cellular sensitivity to the DNA cross-linking agent, mitomycin C (MMC). In the presence of increased sensitivity, MMC causes increased cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle." . [] oboInOwl:hasDbXref , "PMID:14679584" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032189 ; owl:annotatedTarget "An increased cellular sensitivity to the DNA cross-linking agent, diepoxybutane (DEB). In the presence of increased sensitivity, DEB causes cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle." . [] oboInOwl:hasDbXref "PMID:26488288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032190 ; owl:annotatedTarget "Abnormal structure of the meniscus of the knee, two crescent shape fibrocartilaginous pads that disperse the weight of the body and reduce friction of the knee joint during movement." . [] oboInOwl:hasDbXref "PMID:21126396", "PMID:26488288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032191 ; owl:annotatedTarget "A tear in the cartilaginous pad (meniscus) of the knee." . [] oboInOwl:hasDbXref "PMID:23232697", "PMID:26421650" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032192 ; owl:annotatedTarget "Hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast." . [] oboInOwl:hasDbXref , "PMID:10417486", "PMID:9973300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032193 ; owl:annotatedTarget "An abnormal decrease in the average size of low-density lipoprotein particle size in the blood circulation." . [] oboInOwl:hasDbXref "PMID:27012403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032196 ; owl:annotatedTarget "Increased amplitude (0.1 mV or more) and/or duration (40 ms or more) of the S wave as measured in lead I of the electrocardiogram." . [] oboInOwl:hasDbXref "PMID:29279530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032197 ; owl:annotatedTarget "Abnormal depth of the S wave in lead V5 of the electrocardiogram." . [] oboInOwl:hasDbXref "PMID:21470390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032198 ; owl:annotatedTarget "Abnormally short time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032198 ; owl:annotatedTarget "Decreased INR" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "Beilstein:605269" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032198 ; owl:annotatedTarget "Decreased PT" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032198 ; owl:annotatedTarget "Decreased international normalised ratio" . [] oboInOwl:hasDbXref "PMID:29939529" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032199 ; owl:annotatedTarget "Any deviation from the normal amount of time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032199 ; owl:annotatedTarget "Abnormal PT" . [] oboInOwl:hasDbXref "PMID:21502911", "PMID:30363608" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032200 ; owl:annotatedTarget "The presence of thick collagen bundles around blood vessels, often in an onion-skin type whorling pattern." . [] oboInOwl:hasDbXref "PMID:24932450", "PMID:29229593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032201 ; owl:annotatedTarget "The term rotator cuff describes the tendons connecting the infraspinatus, supraspinatus, teres minor, and subscapularis muscles to the humeral head.Traumatic tears of the rotator cuff tend to occur at the tendon-bone junction of the supraspinatus and greater tuberosity of the humerus whereas degenerative tears tend to be seen posteriorly at the junction of the supraspinatus and infraspinatu A rotator cuff tear is when one or more of these tendons tears or detaches from the humerus." . [] oboInOwl:hasDbXref "NCIT:C4756", "PMID:30187167" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032202 ; owl:annotatedTarget "Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognised: the HPV-associated high-grade squamous intraepithelial lesion/usual VIN (HSIL/uVIN) and the non-HPV-associated differentiated VIN (dVIN). HSIL is clinically identified by its multifocal, warty appearance and on histology by conspicuous cytological and architectural atypia. Differentiated VIN, on the other hand, often produces ill-defined lesions, and on histology, notoriously mimics non-neoplastic epithelial disorders (NNED), particularly LS. As a result, dVIN is rarely identified in advance of a diagnosis of invasive malignancy, despite being the precursor lesion of the majority of VSCC." . [] oboInOwl:hasDbXref "PMID:10400105", "PMID:17368236" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032203 ; owl:annotatedTarget "Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236)." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "CAS:109-73-9" . [] oboInOwl:hasDbXref "PMID:24065222" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032205 ; owl:annotatedTarget "An increased circulation of galectin-3 in the blood circulation." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "CAS:109-73-9" . [] oboInOwl:hasDbXref "PMID:30572827" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032208 ; owl:annotatedTarget "An increased concentration of type 1 collagen N-terminal telopeptide (NTx) level in the urine. Generally the test is performed over a period of time, for instance, 10 cc of morning urine can be collected following 12 hours overnight fasting or for 24 hours." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032208 ; owl:annotatedTarget "Increased urine NTx level" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "Gmelin:1784" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "PMID:16387436" . [] oboInOwl:hasDbXref "PMID:26782662" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032212 ; owl:annotatedTarget "An increased number of squamous epithelial cells per high-power field in urinanalysis." . [] oboInOwl:hasDbXref "PMID:29730845" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032215 ; owl:annotatedTarget "Multiple skin warts located in multiple parts of the body, e.g., neck, trunks, and extremities." . [] oboInOwl:hasDbXref "PMID:9824342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032216 ; owl:annotatedTarget "Abnormally increased intraepithelial lymphocyte count. This finding may be appreciated as large numbers of surface intraepithelial lymphocytes as seen (for instance) with hematoxylin and eosin staining of a colonic biopsy sample taken during colonoscopy." . [] oboInOwl:hasDbXref "PMID:16252032", "PMID:23006954" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032217 ; owl:annotatedTarget "A skin nodule that is unusually hard (indurated)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "PMID:23470444" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "PMID:14619112" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "PMID:23734590" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "Reaxys:605269" . [] oboInOwl:hasDbXref "PMID:25654060", "PMID:9420892" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032221 ; owl:annotatedTarget "The engulfing of lymphocytes by hepatocytes, which typically occurs in the interface hepatitis area." . [] oboInOwl:hasDbXref "NCIT:C96470", "PMID:27540339" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032222 ; owl:annotatedTarget "The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification." . [] oboInOwl:hasDbXref "PMID:26085552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032223 ; owl:annotatedTarget "Any of the various types of human blood whose antigen characteristics determine compatibility in transfusion. While the ABO and Rhesus sytems are the most well known, there are in total about 300 different blood type antigens distributed across 34 different blood type systems." . [] oboInOwl:hasDbXref "PMID:15373665", "PMID:26085552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032224 ; owl:annotatedTarget "The ABO system consists of A and B antigens and antibodies against these antigens." . [] oboInOwl:hasDbXref "PMID:21747629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032225 ; owl:annotatedTarget "Perifollicular fibroma is a rare cutaneous hamartoma that shows differentiation in the connective tissue sheath of hair follicles. It can occur as a solitary papule or as multiple lesions. Histologically, the lesion consists of a concentric arrangement of cellular fibrous tissue around a normal hair follicle." . [] oboInOwl:hasDbXref "PMID:17975220" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032226 ; owl:annotatedTarget "Any structural anomaly of the sebaceous glands." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "butan-1-amine" . [] oboInOwl:hasDbXref "PMID:24759166" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032227 ; owl:annotatedTarget "A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elswehere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola." . [] oboInOwl:hasDbXref "NCIT:C43333", "PMID:10522666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032228 ; owl:annotatedTarget "A small benign fibrovascular tumor of the dermal part of the hair disk. Trichodiscoma is rather simple in appearance and consists of a dome-shaped fibrous tumor with a prominent vascular component that fills the papillary dermis under an atrophic epidermis. As in a normal hair disk, a hair follicle may be present at one edge of the papular lesion." . [] oboInOwl:hasDbXref , "PMID:24854381", "PMID:27481040", "PMID:28661185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032229 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against proteins predominantly expressed in perinuclear region of neutrophils." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032229 ; owl:annotatedTarget "p-ANCA positivity" . [] oboInOwl:hasDbXref , "PMID:14646155", "PMID:24854381", "PMID:27481040", "PMID:28661185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032230 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils." . [] oboInOwl:hasDbXref "PMID:21448658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032232 ; owl:annotatedTarget "An increased concentration of the MB isoform of creatine kinase in the blood circulation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032232 ; owl:annotatedTarget "Increased circulating CK MB isoform" . [] oboInOwl:hasDbXref "PMID:21448658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032233 ; owl:annotatedTarget "An increased concentration of the BB isoform of creatine kinase in the blood circulation." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032233 ; owl:annotatedTarget "Increased circulating CK BB isoform" . [] oboInOwl:hasDbXref "PMID:21448658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032234 ; owl:annotatedTarget "An increased concentration of the MM isoform of creatine kinase in the blood circulation." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "1-Aminobutan" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032234 ; owl:annotatedTarget "Increased circulating CK MM isoform" . [] oboInOwl:hasDbXref , "PMID:15804706", "PMID:27431345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032235 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against La/SSB autoantigens." . [] oboInOwl:hasDbXref "PMID:25887201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032236 ; owl:annotatedTarget "An abnormally increased number of immature neutrophils in the peripheral blood circulation." . [] oboInOwl:hasDbXref "PMID:25887201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032237 ; owl:annotatedTarget "An abnormally increased number of myelocytes in the peripheral blood circulation. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and seconday granules, and a nucleus:cytoplasm ratio of 2:1." . [] oboInOwl:hasDbXref "PMID:25887201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032238 ; owl:annotatedTarget "An abnormally increased number of metamyelocytes in the peripheral blood circulation. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with seconday granules, and a nucleus:cytoplasm ratio of 1.5:1." . [] oboInOwl:hasDbXref "PMID:25887201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032239 ; owl:annotatedTarget "An abnormally increased number of band cells in the peripheral blood circulation. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small seconday granules, and a nucleus:cytoplasm ratio of 1:2." . [] oboInOwl:hasDbXref "PMID:12591072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032240 ; owl:annotatedTarget "An increased concentration of E selectin in the blood circulation." . [] oboInOwl:hasDbXref "NCIT:C2940" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032241 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the uterine cervix." . [] oboInOwl:hasDbXref "PMID:28453530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032242 ; owl:annotatedTarget "A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer." . [] oboInOwl:hasDbXref "PMID:6101498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032244 ; owl:annotatedTarget "A reduction in the concentration of thromboxane B2 in the blood circulation." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "1-aminobutane" . [] oboInOwl:hasDbXref "PMID:28130404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032247 ; owl:annotatedTarget "Lasting (uncontrolled) presence of cytomegalovirus in the blood circulation." . [] oboInOwl:hasDbXref "PMID:23843703" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032249 ; owl:annotatedTarget "Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species: Coccidioides immitis and C. posadasii." . [] oboInOwl:hasDbXref "PMID:22546906" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032250 ; owl:annotatedTarget "An infection by Acinetobacter baumannii, a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has a high incidence among immunocompromised individuals, particularly those who have experienced a prolonged (over 90 d) hospital stay." . [] oboInOwl:hasDbXref "PMID:10908370", "PMID:11168676", "PMID:937513" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032252 ; owl:annotatedTarget "A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis." . [] oboInOwl:hasDbXref "PMID:21938183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032253 ; owl:annotatedTarget "A type of granuloma characterized morphologically by the predominance of Langerhans cells with characteristic grooved, folded, indented nuclei in the appropriate milieu that includes variable numbers of eosinophils and histiocytes including multinucleated forms, often appearing similar to osteoclasts or touton like giant cells, neutrophils and small lymphocytes. The concentration of the eosinophilic infiltrate varies from scattered mature cells to sheet-like masses of cells. Occasionally, areas of bone necrosis may interrupt the cellular infiltrate. The foamy cells may also be amassed in clumps, which are of no clinical significance because these clumps represent phagocytosis of lipid debris." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "1-butanamine" . [] oboInOwl:hasDbXref "PMID:26897068", "PMID:30619685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032256 ; owl:annotatedTarget "Histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons." . [] oboInOwl:hasDbXref "PMID:30619685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032257 ; owl:annotatedTarget "Histoplasmosis infection involving multiple sites of the body. Disseminated histoplasmosis can involve various organs, including reticuloendothelial organs, gastrointestinal tract, adrenal glands, central nervous system, endovascular structures, kidney, and skin. It typically presents with systemic symptoms like fever, generalized fatigue, night sweats, weight loss, and the symptoms related to the specific organ involved. Severe disseminated disease can manifest as septic shock, multi organ failure, and ARDS." . [] oboInOwl:hasDbXref "PMID:21810958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032258 ; owl:annotatedTarget "Infection of the lungs with Histoplasma capsulatum. Symptoms may include fever, headache, weakness, chest pain and dry cough. When imaging is done, chest radiographs may show patchy pneumonia involving one or more lobes with adenopathy of the mediastinum or hilum." . [] oboInOwl:hasDbXref "PMID:25403034" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032259 ; owl:annotatedTarget "The term tinea means fungal infection, whereas dermatophyte refers to the fungal organisms that cause tinea. This term refers to a tinea infection that is chronic or recalcitrant to treatment and may be reflective of an immune defect." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "1-butylamine" . [] oboInOwl:hasDbXref "PMID:24624285", "PMID:7472715" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032261 ; owl:annotatedTarget "An infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease." . [] oboInOwl:hasDbXref "PMID:30345099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032262 ; owl:annotatedTarget "A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032262 ; owl:annotatedTarget "Pulmonary TB" . [] oboInOwl:hasDbXref "PMID:9137951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032263 ; owl:annotatedTarget "Abnormal increase in blood pressure. An individual measurement of increased blood pressure does not necessarily imply hypertension. In practical terms, multiple measurements are recommended to diagnose the presence of hypertension." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032263 ; owl:annotatedTarget "Increased BP" . [] oboInOwl:hasDbXref "PMID:24729779" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032264 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor." . [] oboInOwl:hasDbXref "PMID:29651625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032266 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the cerebrospinal fluid (CSF) that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor." . [] oboInOwl:hasDbXref "PMID:19881070", "PMID:29089832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032267 ; owl:annotatedTarget "This sign is created by a nonenhancing thrombus in the dural sinus surrounded by triangular enhancing dura as seen on cross-section. The sign, seen on contrast-enhanced CT scan images, suggests dural sinovenous thrombosis. It is best seen on wider window settings. It is a reliable sign of sinus thrombosis but is seen only in 25-30% of these cases." . [] oboInOwl:hasDbXref "PMID:19881070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032268 ; owl:annotatedTarget "This sign represents thickening and enhancement of the dura mater in continuity with a mass, which on MR images, gives the appearance of a tail arising from the mass. The dural tail is thought to represent reactive change; however, it may also be due to tumor invasion. Three criteria need to be met for a positive dural tail sign: the tail should be seen on two successive images through the tumor, it should taper away from the tumor, and it must enhance more than the tumor." . [] oboInOwl:hasDbXref , "PMID:12832584", "PMID:29089832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032269 ; owl:annotatedTarget "The lemon sign refers to the shape of the fetal skull at ultrasonography (US) when the frontal bones lose their normal convex contour and appear flattened or inwardly scalloped. This gives the skull a shape that is said to resemble a lemon.. The sign is seen on transverse sonograms of the fetal cranium obtained at the level of the ventricles." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "BUTYLAMINE" . [] oboInOwl:hasDbXref "PMID:19881070" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032270 ; owl:annotatedTarget "A tram-track sign is composed of two enhancing areas of tumor separated from each other by the negative defect of the optic nerve. It is seen on contrast-enhanced CT scan and MRI images, in optic nerve sheath meningioma. The sign helps distinguish between optic nerve sheath meningioma and optic glioma. Optic glioma arises from glial cells within the optic nerve and there is no clear separation between the nerve and the tumor; hence the tram-track sign is not seen in optic gliomas. Calcification may be seen in optic nerve sheath meningiomas in 20-50% of cases and hence the tram-track sign may be seen on nonenhanced CT scan images as a linear calcification around the nerve, but this is less common." . [] oboInOwl:hasDbXref "PMID:16300038", "PMID:25861336" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032271 ; owl:annotatedTarget "A type of tubercular infection located outside of the lung, which is the most common location of tuberculosis. There are two types of clinical manifestation of tuberculosis (TB) are pulmonary TB (PTB) and extrapulmonary TB (EPTB). The former is most common. EPTB refers to TB involving organs other than the lungs (e.g., pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges). A patient with both pulmonary and EPTB is classified as a case of PTB." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032271 ; owl:annotatedTarget "Extrapulmonary TB" . [] oboInOwl:hasDbXref "PMID:8412017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032272 ; owl:annotatedTarget "Elevated N-acetylaspartic acid (NAA) in urine. This feature can be measured using gas chromatography-mass spectrometry." . [] oboInOwl:hasDbXref "PMID:8412017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032273 ; owl:annotatedTarget "Concentration of N-acetylaspartic acid in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:8412017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032274 ; owl:annotatedTarget "An abnormally increased concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "PMID:24113666" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032275 ; owl:annotatedTarget "Repeated episodes of a localized, painful cutaneous eruption related to reactivation of varicella zoster virus (VZV) and characterized by a characteristic rash in one or two adjacent dermatomes." . [] oboInOwl:hasDbXref "PMID:26769062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032276 ; owl:annotatedTarget "Abnormally increased prominence of the fat pad underneath the heal. This feature can be appreciated in figure 1 of PMID:26769062." . [] oboInOwl:hasDbXref "ISBN-13:978-0195300451" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032277 ; owl:annotatedTarget "An ovoid depression of the tissue that immediately surrounds the umbilicus, resulting in a lozenge-shaped depression encircling a slightly prominent (protruding) umbilicus." . [] oboInOwl:hasDbXref "PMID:30067929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032281 ; owl:annotatedTarget "Deviation from the normal quantity of base excess, defined as the amount of strong acid (in millimoles per liter) that needs to be added in vitro to 1 liter of fully oxygenated whole blood to return a blood sample to standard conditions (pH of 7.40, Pco2 of 40 mm Hg, and temperature of 37 degrees C)." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "butanamine" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032284 ; owl:annotatedTarget "Ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032285 ; owl:annotatedTarget "Ultra-low vision but with retained ability to perceive the difference between light and dark. Also when light is projected in each of the four quadrants of the visual field, the individual is able to correctly identify the origin of the light stimulus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032286 ; owl:annotatedTarget "Ultra-low vision but with retained ability to perceive the difference between light and dark." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032287 ; owl:annotatedTarget "Ultra-low vision with complete lack of light and form perception." . [] oboInOwl:hasDbXref "PMID:15663032" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032288 ; owl:annotatedTarget "An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains." . [] oboInOwl:hasDbXref "PMID:10926917" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032292 ; owl:annotatedTarget "A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a light chain but not a heavy chain." . [] oboInOwl:hasDbXref "PMID:25368619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032296 ; owl:annotatedTarget "An elevation of circulating IgG level predominantly related to an elevation of one of the four IgG subclasses." . [] oboInOwl:hasDbXref , "PMID:25368619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032297 ; owl:annotatedTarget "An abnormally increased concentration of the IgG3 subtype in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:25368619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032298 ; owl:annotatedTarget "An abnormally increased concentration of the IgG1 subtype in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:25368619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032299 ; owl:annotatedTarget "An abnormally increased concentration of the IgG2 subtype in the blood circulation." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "butylamine" . [] oboInOwl:hasDbXref , "PMID:25368619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032300 ; owl:annotatedTarget "An abnormally increased concentration of the IgG4 subtype in the blood circulation." . [] oboInOwl:hasDbXref "PMID:28722914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032301 ; owl:annotatedTarget "Warts affecting the skin in the genital area (peniile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pdenuculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress." . [] oboInOwl:hasDbXref , "PMID:25783214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032305 ; owl:annotatedTarget "Concentration of mannose-binding protein in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref , "PMID:25783214" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032306 ; owl:annotatedTarget "Concentration of mannose-binding protein in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref , "PMID:28794881", "PMID:2933297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032308 ; owl:annotatedTarget "An elevated concentration of procalcitonin in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032311 ; owl:annotatedTarget "An abnormally elevated concentration of globulins in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "mono-n-butylamine" . [] oboInOwl:hasDbXref "PMID:15834013" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032325 ; owl:annotatedTarget "A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain." . [] oboInOwl:hasDbXref "PMID:16186732" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032326 ; owl:annotatedTarget "Infection with staphylococcus aureus resistant to the antibiotic methicillin (MRSA). MRSA can infect any individual but is more common among hospitalized patients, and can also occur as an opportunistic infection." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032326 ; owl:annotatedTarget "MRSA infection" . [] oboInOwl:hasDbXref "PMID:27195030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032327 ; owl:annotatedTarget "Cystic collection (sac-like, fluid containing pocket of membranous tissue) located in the interhemispheric fissure, with or without communication with the ventricular system." . [] oboInOwl:hasDbXref "PMID:12139272", "PMID:19534789" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032328 ; owl:annotatedTarget "Formation of one or more fibrous bands within the temporomandibular joint (TMJ) with resulting limitation of movement of the TMJ. Adhesions may be seen in degenerative processes that involve the TMJ." . [] oboInOwl:hasDbXref , "PMID:10689646" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032329 ; owl:annotatedTarget "An abnormally elevated concentration of 11-deoxycortisol in the urine." . [] oboInOwl:hasDbXref , "PMID:10689646" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032330 ; owl:annotatedTarget "An abnormally elevated concentration or amount of 11-deoxycorticosterone in the urine." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "monobutylamine" . [] oboInOwl:hasDbXref , "PMID:10689646" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032331 ; owl:annotatedTarget "An abnormally elevated concentration or amount of 11-deoxytetrahydrocorticosterone the urine." . [] oboInOwl:hasDbXref "PMID:22347750", "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032341 ; owl:annotatedTarget "An abnormal reduction in the amount of air a person can expel following maximal inspiration." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032341 ; owl:annotatedTarget "Reduced FVC" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032342 ; owl:annotatedTarget "Reduced FEV1" . [] oboInOwl:hasDbXref "PMID:28342017", "PMID:29630157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032346 ; owl:annotatedTarget "Lichen amyloidosis presents with multiple localized or rarely generalized, hyperpigmented grouped papules with a predilection for the shins, calves, ankles, and dorsa of the feet and thighs." . [] oboInOwl:hasDbXref "PMID:26981113" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032347 ; owl:annotatedTarget "A type of cutaneous amyloidosis that is characterized by hyperpigmented patches with indefinite margins composed of grayish brown macules, often with a reticulated or rippled appearance." . [] oboInOwl:hasDbXref "PMID:28537855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032348 ; owl:annotatedTarget "A type of cutaneous amyloidosis that is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032349 ; owl:annotatedTarget "A increased concentration of serine in the urine." . [] oboInOwl:hasDbXref , "PMID:28980090" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032350 ; owl:annotatedTarget "A increased concentration of sulfocysteine in the urine." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "n-Butylamin" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "n-C4H9NH2" . [] oboInOwl:hasDbXref , "PMID:18566668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032351 ; owl:annotatedTarget "Increased level of phenylalanine in urine." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032352 ; owl:annotatedTarget "Level of methionine in urine above the upper limit of normal." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032353 ; owl:annotatedTarget "Increased level of leucine in urine." . [] oboInOwl:hasDbXref , "PMID:28005993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032355 ; owl:annotatedTarget "A reduction in the maximum expiratory flow per minute, which can be used to measure how fast a subject can exhale as well as to judge the strength of the expiratory muscles and the condition of the large airways." . [] oboInOwl:hasDbXref , "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032356 ; owl:annotatedTarget "An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed before the administration of a bronchodilating medication." . [] oboInOwl:hasDbXref , "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032357 ; owl:annotatedTarget "An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication." . [] oboInOwl:hasDbXref , "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032359 ; owl:annotatedTarget "A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032359 ; owl:annotatedTarget "Decreased FEF25-75%" . [] oboInOwl:hasDbXref , "PMID:24695507" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032360 ; owl:annotatedTarget "A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed before the administration of a bronchodilating medication." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032360 ; owl:annotatedTarget "Decreased pre-bronchodilator FEF25-75%" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_43799 ; owl:annotatedTarget "n-butylamine" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032361 ; owl:annotatedTarget "Decreased post-bronchodilator FEF25-75%" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032362 ; owl:annotatedTarget "An abnormally elevated concentration of corticosterone in the blood." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_4439 ; owl:annotatedTarget "Dermatan" . [] oboInOwl:hasDbXref "PMID:28134589" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032366 ; owl:annotatedTarget "A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_4439 ; owl:annotatedTarget "Dermatan L-iduronate" . [] oboInOwl:hasDbXref "PMID:24381489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032368 ; owl:annotatedTarget "An abnormally low blood pH (usually defined as less than 7.35)." . [] oboInOwl:hasDbXref "PMID:24381489" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032369 ; owl:annotatedTarget "An abnormally high blood pH (usually defined as 7.41 or above)." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "Reaxys:83514" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45212 ; owl:annotatedTarget "Gmelin:185085" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032371 ; owl:annotatedTarget "An increased concentration of isoleucine in the urine." . [] oboInOwl:hasDbXref "PMID:19480920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032373 ; owl:annotatedTarget "The Duffy blood group system is based on the presence of a glycoprotein termed Fy that is on the surface of erythrocytes and some other cells. There are two Duffy antigens named Fya and Fyb, and thus there are four Duffy phenotypes: a+b+, a+b-, a-b+,a-b-." . [] oboInOwl:hasDbXref "PMID:19480920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032374 ; owl:annotatedTarget "Presence of the Duffy Fya antigen." . [] oboInOwl:hasDbXref "PMID:19480920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032375 ; owl:annotatedTarget "Presence of the Duffy Fyb antigen." . [] oboInOwl:hasDbXref "PMID:28105326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032376 ; owl:annotatedTarget "Presence of antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032376 ; owl:annotatedTarget "Anti-B2GPI positivity" . [] oboInOwl:hasDbXref "PMID:25711902" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032377 ; owl:annotatedTarget "An increased concentration in the urine of alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM). AGP is a 41-43-kDa glycoprotein with a pI of 2.8-3.8. AGP is an acute-phase protein that has many activities including, but not limited to, acting as an acute-phase reactant and disease marker, modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism." . [] oboInOwl:hasDbXref "PMID:24286446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032378 ; owl:annotatedTarget "Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching, dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement." . [] oboInOwl:hasDbXref "PMID:21442060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032379 ; owl:annotatedTarget "The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032379 ; owl:annotatedTarget "Sun allergy" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45212 ; owl:annotatedTarget "dihydrogen diphosphate" . [] oboInOwl:hasDbXref "PMID:21442060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032381 ; owl:annotatedTarget "In response to the spring sun distinct inflamed reddened skin develops on the ears, nose, cheeks, fingers, backs of the hands, and the lower arms, on which blisters with serous or hemorrhagic content develop. These dry out with the formation of a blackish scab. After shedding of the scab, depressed, varioliform, often hypopigmented scars remain. In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032382 ; owl:annotatedTarget "UPD" . [] oboInOwl:hasDbXref "PMID:29137034" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032382 ; owl:annotatedTarget "UPD may comprise the whole chromosome, or just part of it (segmental UPD). Isodisomy is presented as 2 copies from the same chromosome of a parent, and heterodisomy is presented as 1 copy of each of the 2 homologues from the same parent. UPD is related to abnormalities formed during meiosis, fertilization, and mitosis. There are 5 different mechanisms that explain the etiology of UPD, including Trisomic rescue; Nullisomic gamete complementation; Monosomic rescue; Mitotic aberrations; and Structural chromosome aberrations. If prenatal genetic analysis reveals a homologous robertsonian translocation, the risk of fetal UPD is very high, and a marker chromosome or chromosome aneuploidy can be associated with UPD." . [] oboInOwl:hasDbXref "PMID:25547535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032383 ; owl:annotatedTarget "A type of uniparental disomy in which the two different chromosomes (or chromosome segments) of the same parent are transmitted." . [] oboInOwl:hasDbXref "PMID:25547535" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032384 ; owl:annotatedTarget "A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted." . [] oboInOwl:hasDbXref "PMID:19787826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032386 ; owl:annotatedTarget "An abnormally increased concentration of transferrin in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032388 ; owl:annotatedTarget "Nodules of heterotopia along the ventricular walls. There can be a single nodule or a large number of nodules, they can exist on either or both sides of the brain at any point along the higher ventricle margins, they can be small or large, single or multiple." . [] oboInOwl:hasDbXref , "PMID:22427329", "PMID:22473091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032389 ; owl:annotatedTarget "A large mass of heterotopia in a laminar configuration along the ventricular walls. Usually bilateral." . [] oboInOwl:hasDbXref , "PMID:22315185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032390 ; owl:annotatedTarget "Heterotopia that forms a continuous wavy line along the ventricular wall." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032391 ; owl:annotatedTarget "A form of heterotopia were the mislocalized gray matter is located deep within the white matter." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45212 ; owl:annotatedTarget "H2P2O7(2-)" . [] oboInOwl:hasDbXref , "PMID:23246003", "PMID:29654772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032392 ; owl:annotatedTarget "Solid nodular heterotopia situated in the region of the peritrigonal optic pathway posterior to the deep gray nuclei." . [] oboInOwl:hasDbXref , "PMID:24859200" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032393 ; owl:annotatedTarget "Subcortical heterotopia consisting of a bilateral and symmetric single continuous, undulating ribbon-like layer of gray matter located in the frontal, parietal and occipital lobes. It has no visible connection to the overlying cortex." . [] oboInOwl:hasDbXref , "PMID:22578326" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032394 ; owl:annotatedTarget "Subcortical heterotopia extending along the mesial aspect of the lateral ventricles, with direct connection to mesial polymicrogyria-like cortex at the anterior and posterior limits of the heterotopia." . [] oboInOwl:hasDbXref , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032395 ; owl:annotatedTarget "Large subcortical heterotopia of variable morphology wiht streaks and swirls. These always connect to the overlying cortex in at least one, but usually in multiple, locations. Spaces with the signal intensity of CSF are usually seen within the heterotopia." . [] oboInOwl:hasDbXref , "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032396 ; owl:annotatedTarget "Linear heterotopia spanning from the cerebral mantle from the pia to the ependyma." . [] oboInOwl:hasDbXref , "PMID:29695388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032397 ; owl:annotatedTarget "An increased concentration of citrulline in the urine." . [] oboInOwl:hasDbXref , "PMID:26130693", "PMID:26564436", "PMID:32895508" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032398 ; owl:annotatedTarget "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032399 ; owl:annotatedTarget "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation but with a normal thickness of the cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032400 ; owl:annotatedTarget "An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation and a thickened cortex intermediate between pachygyria and polymicrogyria." . [] oboInOwl:hasDbXref , "PMID:21123949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032401 ; owl:annotatedTarget "A increased concentration of aspartic acid in the urine." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45212 ; owl:annotatedTarget "PYROPHOSPHATE 2-" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032403 ; owl:annotatedTarget "An increased concentration of asparagine in the urine." . [] oboInOwl:hasDbXref "PMID:9490992" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032404 ; owl:annotatedTarget "An abnormal bulge or lump in a testis. A testicular mass has a long differential diagnosis including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer." . [] oboInOwl:hasDbXref , "PMID:7688003" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032405 ; owl:annotatedTarget "An increased level of phosphoserine in the urine." . [] oboInOwl:hasDbXref , "PMID:20301504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032406 ; owl:annotatedTarget "A type of perisylvian polymicrogyria that largely affects one side of the brain." . [] oboInOwl:hasDbXref , "PMID:20301504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032407 ; owl:annotatedTarget "A type of perisylvian polymicrogyria that affects both sides of the brain." . [] oboInOwl:hasDbXref "PMID:15887452" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032408 ; owl:annotatedTarget "A breast lump is any discrete mass in a breast noticed by the patient, significant other, or physician." . [] oboInOwl:hasDbXref , "PMID:28413838" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032409 ; owl:annotatedTarget "A form of subcortical heterotopia with mislocalized gray matter within the white matter.It is defined as longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter. It is part of the lissencephaly spectrum." . [] oboInOwl:hasDbXref , "PMID:20301504" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032410 ; owl:annotatedTarget "Symmetric generalized polymicrogyria with no obvious gradient or region of maximal severity; may have abnormal high signal in white matter." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032410 ; owl:annotatedTarget "Bilateral generalised polymicrogyria" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032411 ; owl:annotatedTarget "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the occipital cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032412 ; owl:annotatedTarget "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible in the frontal and temporal lobes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032413 ; owl:annotatedTarget "Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the whole brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032414 ; owl:annotatedTarget "The presence of an elevated amount of 5-hydroxylysine in the urine. This compound is a hydroxylated derivative of the amino acid lysine that is present in certain collagens." . [] oboInOwl:hasDbXref , "PMID:20301504", "PMID:21127420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032415 ; owl:annotatedTarget "Polymicrogyria in parasagittal and mesial aspects of parieto-occipital cortex." . [] oboInOwl:hasDbXref , "PMID:23371018", "PMID:24425852" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032416 ; owl:annotatedTarget "A localized dilation of microvasculature formed due to disruption of the internal elastic lamina of a retinal capillary blood vessel. The lesions present as small circular, red dots having distinct margins and are no larger than a blood vessel width at the disk margin. This expansion disturbs the normal flow pattern, changing shear force and pressure along the vessel. Shear force plays a key role in promoting the differentiation and proliferation of endothelial cells." . [] oboInOwl:hasDbXref "PMID:21204717", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032417 ; owl:annotatedTarget "Circumferential fibrosis in the interstitium surrounding Bowman's capsule" . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032418 ; owl:annotatedTarget "An abnormal concentration of an HDL subfraction, which can be determined by methods such as electrophoresis followed by densitometric determination of the areas under the peaks. Large HDL subfractions are defined as HDL1 (greater than 12 nm), HDL2b (9.7-12 nm), and HDL2a (8.8-9.69 nm). Small HDL subfractions are defined as HDL3a (8.2-8.79 nm), HDL3b (7.8-8.19 nm), and HDL3c (7.20-7.79 nm)." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032419 ; owl:annotatedTarget "Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032420 ; owl:annotatedTarget "An elevation above the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032421 ; owl:annotatedTarget "A reduction below the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "1-methylpropyl" . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032422 ; owl:annotatedTarget "Any deviation from the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032423 ; owl:annotatedTarget "A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032424 ; owl:annotatedTarget "An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032425 ; owl:annotatedTarget "Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032426 ; owl:annotatedTarget "Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032427 ; owl:annotatedTarget "Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032428 ; owl:annotatedTarget "An elevation above the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032429 ; owl:annotatedTarget "A reduction below the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032430 ; owl:annotatedTarget "An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032431 ; owl:annotatedTarget "A reduction below the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "SEC-BUTYL GROUP" . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032432 ; owl:annotatedTarget "An elevation above the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." . [] oboInOwl:hasDbXref "PMID:17291473" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032433 ; owl:annotatedTarget "A reduction below the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." . [] oboInOwl:hasDbXref "PMID:11483823" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032434 ; owl:annotatedTarget "Separation of the umbilical cord occurs at an abnormally late timepoint." . [] oboInOwl:hasDbXref "PMID:30020710" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032435 ; owl:annotatedTarget "An infection of the umbilicus and/or surrounding tissues occurring in the neonatal period." . [] oboInOwl:hasDbXref , "PMID:17852082" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032437 ; owl:annotatedTarget "An abnormal decrease of the C-reactive protein level in serum." . [] oboInOwl:hasDbXref "PMID:18065693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032438 ; owl:annotatedTarget "Abnormally increased variability in the size of platelets." . [] oboInOwl:hasDbXref "PMID:30408667", "PMID:8077583" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032439 ; owl:annotatedTarget "An abnormally increased sensitivity to airborn particles. This can be diagnosed on the basis of the medical history, taking into account seasonality or a relationship to the concentration of airborn particles in the environment of the affected individual. Aerosol challenge is a gold standard of establishment of the symptom. There exist particle hypersensitivity (diesel exhaust, metals, inorganic material) vs. allergen (including pollen dander, etc) hypersensitivity. The responses are usually different and testing for allergen hypersensitivity is done in concert with serum IgE and or skin testing to the suspected allergen." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "butan-2-ido" . [] oboInOwl:hasDbXref "PMID:20028879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032445 ; owl:annotatedTarget "A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid." . [] oboInOwl:hasDbXref "PMID:18195376", "PMID:20028879", "PMID:24106540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032446 ; owl:annotatedTarget "Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "butan-2-yl" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032446 ; owl:annotatedTarget "Pulmonary bullae" . [] oboInOwl:hasDbXref "PMID:12934786", "PMID:18195376", "PMID:20028879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032447 ; owl:annotatedTarget "A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter. CT findings show a bleb as a thin-walled cystic air space contiguous with the pleura." . [] oboInOwl:hasDbXref "PMID:29939570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032448 ; owl:annotatedTarget "A condition in which production of hydrochloric acid in the stomach is absent." . [] oboInOwl:hasDbXref "PMID:25487405", "PMID:26017636" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032449 ; owl:annotatedTarget "An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane." . [] oboInOwl:hasDbXref "PMID:24034073", "PMID:26538887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032451 ; owl:annotatedTarget "Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented." . [] oboInOwl:hasDbXref "PMID:24034073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032452 ; owl:annotatedTarget "Oral melanoacanthoma usually presents as an asymptomatic, ill-defined, rapidly enlarging, macular pigmentation. Although most lesions are heavily pigmented, the coloration may or may not be uniform. Any mucosal site may be affected, but buccal mucosal involvement is most common. Although typically solitary, rare patients may present with multifocal lesions." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "sec-butyl" . [] oboInOwl:hasDbXref "PMID:24034073", "PMID:26538887" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032454 ; owl:annotatedTarget "Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture." . [] oboInOwl:hasDbXref "PMID:20142805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032455 ; owl:annotatedTarget "Reduced level of CD18 on the granulocyte surface. This feature can be assessed by flow cytometry." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032456 ; owl:annotatedTarget "A type of lissencephaly whereby upon neuropathological examination the cortical plate is severely disorganized with a festooned-like pattern and with neither lamination nor clear demarcation between white and grey matter." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "Allantoin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "-CH(CH3)-CH2-CH3" . [] oboInOwl:hasDbXref , "PMID:28440899" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032457 ; owl:annotatedTarget "Pachygyria-agyria spectrum whereby at neuropathological examination the cortical plate consists of a two-three layered organization made up of a molecular layer, a relatively thin wavy layer with a higher cellular density and a third layer with lower cellularity." . [] oboInOwl:hasDbXref "PMID:15894597" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032458 ; owl:annotatedTarget "A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located." . [] oboInOwl:hasDbXref "PMID:4200723" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032459 ; owl:annotatedTarget "Any deviation from the normal level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." . [] oboInOwl:hasDbXref "PMID:17701900", "PMID:20301731" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032460 ; owl:annotatedTarget "Abnormally reduced level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate." . [] oboInOwl:hasDbXref "PMID:29167646" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032462 ; owl:annotatedTarget "An elevation beyond the normal concentration of palmitate (palmitic acid) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:27185500" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032463 ; owl:annotatedTarget "A reduction below the normal concentration of fibronectin the the blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "CH3-CH2-CH(CH3)-" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032464 ; owl:annotatedTarget "Underdevelopment of the ureter." . [] oboInOwl:hasDbXref , "PMID:28904941" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032465 ; owl:annotatedTarget "Muscular projections that protrude into the lumen of the bladder, criss-crossing the walls of the bladder on its inner surface." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "but-2-yl" . [] oboInOwl:hasDbXref , "PMID:27863011" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032466 ; owl:annotatedTarget "Lack of formation (congenital absence) of the olfactory bulb." . [] oboInOwl:hasDbXref "PMID:26000135" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032469 ; owl:annotatedTarget "Presence of autoantibodies against the asialoglycoprotein receptor (ASGPR) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:22884362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032470 ; owl:annotatedTarget "The hair shaft has a beaded appearance due to the presence of elliptical nodes that have the diameter of normal hair and are medullated, regularly separated by internodes that are narrow, devoid of medulla and are the site of fracture." . [] oboInOwl:hasDbXref , "PMID:20198472", "PMID:22427329" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032471 ; owl:annotatedTarget "Polymicrogyria affecting one or multiple small areas of the cerebral cortex." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032475 ; owl:annotatedTarget "A malformation of the pachygyria-agyria spectrum. A 6-layered cortex is characterized by bands of ectopic neurons of varying shape and size organized in columns or clusters, lying in a reduced rim of white matter. Layers I and II of the cortex are well defined, and pyramidal and polymorphic neurons of layers III, IV, V, and VI are found more or less in their appropriate location." . [] oboInOwl:hasDbXref "PMID:24311540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032478 ; owl:annotatedTarget "Protrusion of the arachnoid and dura through spinal foramina." . [] oboInOwl:hasDbXref "PMID:27545678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032479 ; owl:annotatedTarget "It is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development." . [] oboInOwl:hasDbXref "PMID:30823446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032480 ; owl:annotatedTarget "An increased amount of beta-aminoisobutyric acid in the urine. Beta-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "isoleucine side-chain" . [] oboInOwl:hasDbXref "PMID:26358773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032484 ; owl:annotatedTarget "An elevated concentration of sodium in feces." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032484 ; owl:annotatedTarget "Elevated faecal sodium" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032485 ; owl:annotatedTarget "Abnormal faecal osmolality" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032486 ; owl:annotatedTarget "Elevated faecal osmolality" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032487 ; owl:annotatedTarget "Reduced faecal osmolality" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032488 ; owl:annotatedTarget "Abnormal faecal pH" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032489 ; owl:annotatedTarget "Elevated faecal pH" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032490 ; owl:annotatedTarget "Decreased faecal pH" . [] oboInOwl:hasDbXref , "PMID:22241104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032491 ; owl:annotatedTarget "An increased level of the non-proteinogenic amino acid argininosuccinic acid in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:28533781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032492 ; owl:annotatedTarget "Presence of antibodies in the serum that react against myelin oligodendrocyte glycoprotein." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45557 ; owl:annotatedTarget "s-butyl" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032492 ; owl:annotatedTarget "Anti-MOG antibody positivity" . [] oboInOwl:hasDbXref "PMID:27131402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032493 ; owl:annotatedTarget "An abnormally high concentration of trypsinogen in the blood circulation." . [] oboInOwl:hasDbXref "PMID:12894995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032495 ; owl:annotatedTarget "A deviation from the normal proportion of terminal to vellus hairs." . [] oboInOwl:hasDbXref "PMID:23044568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032496 ; owl:annotatedTarget "An increased proportion of terminal hairs compared to vellus hairs." . [] oboInOwl:hasDbXref "PMID:23044568" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032497 ; owl:annotatedTarget "A terminal:vellus ratio under 4:1 is characteristic of androgenetic alopecia." . [] oboInOwl:hasDbXref "PMID:9665278" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032499 ; owl:annotatedTarget "The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation." . [] oboInOwl:hasDbXref "PMID:26019410" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032504 ; owl:annotatedTarget "An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk." . [] oboInOwl:hasDbXref "PMID:30564365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032505 ; owl:annotatedTarget "Pharyngeal spasms provoked by an attempt to drink." . [] oboInOwl:hasDbXref "PMID:23572346" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032506 ; owl:annotatedTarget "Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb." . [] oboInOwl:hasDbXref "PMID:22690353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032508 ; owl:annotatedTarget "Habitual insertion of foreign bodies into bodily orifices." . [] oboInOwl:hasDbXref "PMID:26985115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032509 ; owl:annotatedTarget "Onychotillomania is characterized by the compulsive or irresistible urge in patients to pick at, pull off, or harmfully bite or chew their nails." . [] oboInOwl:hasDbXref "PMID:21391749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032513 ; owl:annotatedTarget "Four-vessel umbilical cord containing two arteries and two veins." . [] oboInOwl:hasDbXref "PMID:19875171" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032514 ; owl:annotatedTarget "A congenital developmental anomaly characterized by the presence of two (instead of the normal one) lacrimal punctum on one or both sides of the face." . [] oboInOwl:hasDbXref "PMID:20092423" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032515 ; owl:annotatedTarget "A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements." . [] oboInOwl:hasDbXref "PMID:20092423" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032516 ; owl:annotatedTarget "Infection that extends deeply into the dermis by dermatophytes, fungi that typically cause different types of superficial infection (tinea) or skin, hair, or nails." . [] oboInOwl:hasDbXref "PMID:22435879", "PMID:29861637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032517 ; owl:annotatedTarget "Majocchi's granuloma (MG) is an inflammatory and granulomatous, dermatophytic infection characterized by a granulomatous inflammation around the hair follicle. Histopathologically, MG demonstrates a nodular perifollicular granulomatous infiltrate of lymphoid cells, macrophages, epithelioid cells, multinucleated giant cells, and neutrophils. Unlike superficial dermatophytoses, fungal hyphae and spores can be detected not only on the surface of the epidermis but also within or around the hair follicles." . [] oboInOwl:hasDbXref "PMID:20092423", "PMID:29861637" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032518 ; owl:annotatedTarget "A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs." . [] oboInOwl:hasDbXref "PMID:5614071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032519 ; owl:annotatedTarget "Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals." . [] oboInOwl:hasDbXref "PMID:8132119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032521 ; owl:annotatedTarget "Involuntary, tic-like movements consisted of crossing both arms across the chest and tensing the body or clasping the hands and squeezing the arms to the sides. The movements last a few seconds and may occur in series or flurries, generally accompanied by facial grimacing and occasional grunting." . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032521 ; owl:annotatedTarget "Spasmodic upper-body squeeze" . [] oboInOwl:hasDbXref "PMID:24932450" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032523 ; owl:annotatedTarget "An abnormal increase in the thickness (diameter) of a tendon." . [] oboInOwl:hasDbXref "PMID:7246605" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032524 ; owl:annotatedTarget "Length of the thumb is greater than normal." . [] oboInOwl:hasDbXref "PMID:25485164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032530 ; owl:annotatedTarget "Reduced level of succinic semialdehyde dehydrogenase (SSADH)." . [] oboInOwl:hasDbXref "PMID:25485164" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032531 ; owl:annotatedTarget "Abnormally increased level of gamma-amino butyric acid (GABA) in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasDbXref "PMID:25485164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032532 ; owl:annotatedTarget "Abnormally increased level of 4-hydroxybutyric acid in the cerebrospinal fluid (CSF)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032532 ; owl:annotatedTarget "Elevated CSF GHB levels" . [] oboInOwl:hasDbXref "PMID:28278308" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032533 ; owl:annotatedTarget "An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies." . [] oboInOwl:hasDbXref "PMID:20301630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032536 ; owl:annotatedTarget "An abnormally elevated number of lymph nodes in an anatomical region." . [] oboInOwl:hasDbXref "PMID:24857030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032537 ; owl:annotatedTarget "A delay in healing of a fracture past the expected duration." . [] oboInOwl:hasDbXref "PMID:23444103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032538 ; owl:annotatedTarget "A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lenghten as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "Beilstein:506796" . [] oboInOwl:hasDbXref "PMID:26672439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032541 ; owl:annotatedTarget "Knuckle pads are benign fibrofatty subcutaneous pads located over the proximal interphalangeal (PIP) joints that can be mistaken for arthritis. Rarely they affect the dorsal aspect of the metacarpophalangeal (MCP) joints. Clinically they are painless and often affect both hands in an asymmetrical pattern." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032541 ; owl:annotatedTarget "Knuckle pads on dorsal aspect of finger joints" . [] oboInOwl:hasDbXref "PMID:23949189", "PMID:29970776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032543 ; owl:annotatedTarget "Expectoration (coughing up) of a broncholith. Broncholithiasis is defined as the presence of calculi in the tracheobronchial tree. It is a rare disease but can be characterized by clinical and radiological findings of a calcified lymph node eroding bronchial wall and opening into the bronchial lumen." . [] oboInOwl:hasDbXref "PMID:26253854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032547 ; owl:annotatedTarget "An abnormal decrease of the pressure within the eye." . [] oboInOwl:hasDbXref "PMID:25077064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032548 ; owl:annotatedTarget "Abnormally elevated placental thickness." . [] oboInOwl:hasDbXref "PMID:441119" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032549 ; owl:annotatedTarget "Persistence beyond the normal age (roughly the first half of the first year of life) of the asymmetric tonic neck reflex (ATNR), which is an easily elicited primitive reflex in the immediate newborn period. The ATNR refers to the phenomenon whereby when the face of an infant is turned to one side, the ipsilateral arm and leg extend and the contralateral arm and leg flex. This posture has been compared to a typical posture of fencers." . [] oboInOwl:hasDbXref , "PMID:21250106", "PMID:26331020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032550 ; owl:annotatedTarget "Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets." . [] oboInOwl:hasDbXref "PMID:21766771" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032551 ; owl:annotatedTarget "Enlarged, bulging blood vessels in and around the anus often associated with rectal bleeding, itching, and pain." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032551 ; owl:annotatedTarget "Haemorrhoids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032551 ; owl:annotatedTarget "Piles" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "CAS:123-76-2" . [] oboInOwl:hasDbXref "PMID:2797223" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032556 ; owl:annotatedTarget "Persistent blue color of the skin that surrounds the mouth." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032556 ; owl:annotatedTarget "Bluish around mouth" . [] oboInOwl:hasDbXref "PMID:24198516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032557 ; owl:annotatedTarget "A past medical history of hematopoietic stem cell transplantation involving myeloablative chemoradiotherapy followed by stem cell rescue with autologous or human leukocyte antigen (HLA)-matched stem cells derived from a donor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032557 ; owl:annotatedTarget "Status post haematopoietic stem cell transplantation" . [] oboInOwl:hasDbXref "PMID:30867909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032558 ; owl:annotatedTarget "Sperm cells lacking flagella." . [] oboInOwl:hasDbXref "PMID:30867909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032559 ; owl:annotatedTarget "Sperm cells with abnormally short flagella." . [] oboInOwl:hasDbXref "PMID:28552195" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032560 ; owl:annotatedTarget "Sperm cells whose flagella are twisted (coiled)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032561 ; owl:annotatedTarget "Small-head sperm" . [] oboInOwl:hasDbXref "PMID:28692759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032562 ; owl:annotatedTarget "Sperm with cigar-shaped heads that gradually dimish in diameter (taper)." . [] oboInOwl:hasDbXref , "PMID:21250106" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032563 ; owl:annotatedTarget "Presence of teardrop-shaped red blood cells." . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "CAS:123-76-2" . [] oboInOwl:hasDbXref "PMID:20532706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032564 ; owl:annotatedTarget "Inflammation of the ileum." . [] oboInOwl:hasDbXref "PMID:18427055" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032565 ; owl:annotatedTarget "A breach of the continuity of the mucous membrane of the vagina caused by sloughing out of inflamed necrotic tissue, usually associated with eschars (slough or piece of dead tissue) and with violaceous to erythematous borders." . [] oboInOwl:hasDbXref , "PMID:16988104", "PMID:19202968", "PMID:28821482" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032566 ; owl:annotatedTarget "Enlarged, oval-shaped erythrocytes (red blood cells)." . [] oboInOwl:hasDbXref , "PMID:26124059", "PMID:29950951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032567 ; owl:annotatedTarget "An increased lipid content in the urine." . [] oboInOwl:hasDbXref "PMID:28593486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032568 ; owl:annotatedTarget "Distal tubular epithelial cells in which globotriaosylceramide (Gb3) has accumulated. they are the characteristic feature of Fabry disease. Urinary mulberry bodies are a component of mulberry cells that can be distinguished easily from fat particles by their inner lamellar appearance." . [] oboInOwl:hasDbXref "PMID:16324092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032570 ; owl:annotatedTarget "Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032570 ; owl:annotatedTarget "Pontine ischaemic lacunes" . [] oboInOwl:hasDbXref "PMID:30918116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032571 ; owl:annotatedTarget "An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "N-(2,5-dioxoimidazolidin-4-yl)urea" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "Gmelin:164703" . [] oboInOwl:hasDbXref "PMID:30847922" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032573 ; owl:annotatedTarget "Increased levels of urinary cytidine, a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1 glycosidic bond." . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "LIPID_MAPS_instance:LMFA01060006" . [] oboInOwl:hasDbXref "PMID:30847922" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032574 ; owl:annotatedTarget "Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond." . [] oboInOwl:hasDbXref "PMID:25102815" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032575 ; owl:annotatedTarget "A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid." . [] oboInOwl:hasDbXref , "PMID:10581255", "PMID:16053906", "PMID:28575298" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032576 ; owl:annotatedTarget "Intracellular accumulation of the lipid-linked oligosaccharide intermediate Man5GlcNAc2-PP-dolichol." . [] oboInOwl:hasDbXref "PMID:24688753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032577 ; owl:annotatedTarget "Presence of a predominant T cell clone. In PCR-based assays, this finding is inferred on the basis of one or two prominent bands within a valid size range. In NGS-based assays, this finding is inferred on the basis of a high number of reads that map to a single T cell receptor clone." . [] oboInOwl:hasDbXref "PMID:30542631" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032578 ; owl:annotatedTarget "An epithelial lined cyst filled with gelatinous material. The gelatinous material commonly contains mucin, old blood, cholesterol, and ions. Most colloid cysts identified are currently asymptomatic and identified incidentally on imaging. When a colloid cyst does cause issues, it most commonly causes obstructive hydrocephalus." . [] oboInOwl:hasDbXref "NCIT:C3438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032579 ; owl:annotatedTarget "A benign focal growth composed of vascular tissue." . [] oboInOwl:hasDbXref "PMID:25274757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032580 ; owl:annotatedTarget "Abnormal structure of the bulbus cordis, which is the single outflow tract of the heart during early embryogenesis." . [] oboInOwl:hasDbXref "PMID:25813241" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032581 ; owl:annotatedTarget "Any structural anomaly of the interstitium of the kidney. The renal interstitium is defined as the intertubular, extraglomerular, extravascular space of the kidney. It is bounded on all sides by tubular and vascular basement membranes and is filled with cells, extracellular matrix, and interstitial fluid." . [] oboInOwl:hasDbXref "PMID:19672113", "PMID:25887903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032582 ; owl:annotatedTarget "Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles." . [] oboInOwl:hasDbXref "PMID:19672113", "PMID:25887903" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032583 ; owl:annotatedTarget "Accumulation of foam cells (FC) in glomeruli of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "PMID:13215009" . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032584 ; owl:annotatedTarget "Increased numbers of neutrophils in the interstitial tissues of the kidney." . [] oboInOwl:hasDbXref "PMID:10052481", "PMID:20336051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032585 ; owl:annotatedTarget "Increased numbers of eosinophils in the interstitial tissues of the kidney." . [] oboInOwl:hasDbXref "PMID:28904438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032586 ; owl:annotatedTarget "Increased numbers of plasma cells in the interstitial tissues of the kidney." . [] oboInOwl:hasDbXref "PMID:23221343" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032587 ; owl:annotatedTarget "The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney." . [] oboInOwl:hasDbXref "PMID:20345957" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032588 ; owl:annotatedTarget "Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032589 ; owl:annotatedTarget "Infiltration of the renal tubular epithelium by lymphocytes." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032590 ; owl:annotatedTarget "Infiltration of the renal tubular epithelium by neutrophils." . [] oboInOwl:hasDbXref "PMID:26491580" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032591 ; owl:annotatedTarget "Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney." . [] oboInOwl:hasDbXref "PMID:28398539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032593 ; owl:annotatedTarget "A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented." . [] oboInOwl:hasDbXref "PMID:29875323" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032594 ; owl:annotatedTarget "Naked basement membranes without tubular epithelium." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "PMID:16662002" . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032595 ; owl:annotatedTarget "Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032596 ; owl:annotatedTarget "Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032597 ; owl:annotatedTarget "At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032598 ; owl:annotatedTarget "Tubular cross section with round/irregular cytoplasmic protrusion, shaped like the Greek capital letter Omega (or it may be more vertically elongated Omega), pinched off from apical membrane without apparent closure of the lumen, involving over 50 percent of the tubular cells in cross section. The feature can be further classified into proximal or distal tubule." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "PMID:19246769" . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032600 ; owl:annotatedTarget "Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032601 ; owl:annotatedTarget "Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032602 ; owl:annotatedTarget "Tubular epithelium with nucleoli clearly visible at 100-fold magnification." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032603 ; owl:annotatedTarget "Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032604 ; owl:annotatedTarget "Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "PMID:23627123" . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032605 ; owl:annotatedTarget "At least one tubular epithelial cell with average sized cytoplasmic area and a nuclear area 3 times greater than average sized nuclei." . [] oboInOwl:hasDbXref "PMID:31076149" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032606 ; owl:annotatedTarget "Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032607 ; owl:annotatedTarget "Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen." . [] oboInOwl:hasDbXref , "PMID:27211375" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032608 ; owl:annotatedTarget "A type of renal tubular atrophy characterized by a thyroid-like appearance, with small round tubules with markedly flattened, simplified epithelium and uniform intratubular casts." . [] oboInOwl:hasDbXref , "PMID:27211375", "PMID:7906246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032609 ; owl:annotatedTarget "A type of renal tubular atrophy characterized by endocrine-like appearance of tubules, which are small and have narrow lumina, clear cells, and relatively thin basement membranes." . [] oboInOwl:hasDbXref "PMID:23303798" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032610 ; owl:annotatedTarget "Renal tubulointerstitial infiltration of mycobacteria identified on acid-fast or Fite stains. Can be associated with granulomatous inflammation." . [] oboInOwl:hasDbXref , "PMID:25441434", "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032611 ; owl:annotatedTarget "Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment." . [] oboInOwl:hasDbXref "PMID:19760621", "PMID:22486404" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032612 ; owl:annotatedTarget "A hallux (big toe) with three phalanges in a single, proximo-distal axis." . [] oboInOwl:hasDbXref , "PMID:25852856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032613 ; owl:annotatedTarget "Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation." . [] oboInOwl:hasDbXref "PMID:21427073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032614 ; owl:annotatedTarget "Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "Reaxys:506796" . [] oboInOwl:hasDbXref , "PMID:11058626" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032615 ; owl:annotatedTarget "A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images." . [] oboInOwl:hasDbXref "PMID:11423587", "PMID:28509073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032616 ; owl:annotatedTarget "Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining)." . [] oboInOwl:hasDbXref , "PMID:20709744", "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032617 ; owl:annotatedTarget "A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032617 ; owl:annotatedTarget "Renal interstitial haemorrhage" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "4-oxopentanoic acid" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "3-acetylpropionic acid" . [] oboInOwl:hasDbXref , "PMID:27998164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032620 ; owl:annotatedTarget "An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis." . [] oboInOwl:hasDbXref , "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032621 ; owl:annotatedTarget "At least one tubular cross section with all tubular epithelial nuclei having a chromatin pattern resembling normal mature lymphocytes." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "3-ketobutane-1-carboxylic acid" . [] oboInOwl:hasDbXref , "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032622 ; owl:annotatedTarget "Dilatation (expansion beyond the normal dimension) of the cavity (lumen) of tubules of the kidney. The tubular cross section displays an attenuated brush border (apical PAS positivity greater than 10 percent of the normal expected height, but unequivocally less than normal expected height), resulting in an apparent increase in the size of lumen." . [] oboInOwl:hasDbXref , "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032623 ; owl:annotatedTarget "Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast." . [] oboInOwl:hasDbXref "PMID:28398539" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032624 ; owl:annotatedTarget "A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green)." . [] oboInOwl:hasDbXref "PMID:21959738" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032625 ; owl:annotatedTarget "Casts that contain red blood cells and are located within the tubuli of the kidney." . [] oboInOwl:hasDbXref "PMID:20064951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032629 ; owl:annotatedTarget "Intratubular crystals composed of 2,8-dihydroxyadenine are small needle-shaped brownish crystals that are highly birefringent under polarized light and black by Jones methenamine silver." . [] oboInOwl:hasDbXref , "PMID:26916380" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032630 ; owl:annotatedTarget "The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules." . [] oboInOwl:hasDbXref , "PMID:25441434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032631 ; owl:annotatedTarget "A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. On H&E (red granular), PAS (purple), trichrome (red granular), Hall (yellow brown). Stain positively for Hemoglobin A." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032631 ; owl:annotatedTarget "Intratubular haemoglobin casts" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "allantoin" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "4-ketovaleric acid" . [] oboInOwl:hasDbXref "PMID:28584810" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032632 ; owl:annotatedTarget "Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei." . [] oboInOwl:hasDbXref , "PMID:393892" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032633 ; owl:annotatedTarget "A type of acellular urinary cast located within the distal tubules of the kidney and that is composed only of Tamm-Horsfall glycoprotein. Correspondingly, these casts have a low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends." . [] oboInOwl:hasDbXref , "PMID:28115066", "PMID:29942498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032634 ; owl:annotatedTarget "Casts located within the tubuli of the kidney and that contain myoglobin. Myoglobin casts are composed of round granules that may line up in chains or aggregate in clusters. Their color ranges from pink to red-brown with hematoxylin and eosin stain, light brown to black with Jones methenamine silver stain, pink to bright magenta with periodic acid-Schiff stain, and bright red with trichrome stain. Immunoperoxidase staining with antibody to myoglobin is stronglypositive in the casts.Electron microscopy shows globular casts with an electron-dense core and a somewhat less-intense periphery. Substructure is absent. This feature may be accompanied by acute tubular injury with variable flattening of tubular epithelial cells, loss of brush borders, and intratubular sloughed epithelial cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032635 ; owl:annotatedTarget "Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "4-oxovaleric acid" . [] oboInOwl:hasDbXref , "PMID:24454932" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032637 ; owl:annotatedTarget "Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032637 ; owl:annotatedTarget "Renal interstitial oedema" . [] oboInOwl:hasDbXref "PMID:3680522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032638 ; owl:annotatedTarget "An abnormally increased amount of mevanolate in the urine. Mevanolate is that hydroxy monocarboxylic acid anion that is the conjugate base of mevalonic acid." . [] oboInOwl:hasDbXref "PMID:27102039", "PMID:31892015" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032639 ; owl:annotatedTarget "An increased concentration of cystine within white blood cells." . [] oboInOwl:hasDbXref "PMID:15784687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032640 ; owl:annotatedTarget "An increased concentration of C-C motif chemokine ligand 18 in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:26413275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032641 ; owl:annotatedTarget "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present." . [] oboInOwl:hasDbXref , "PMID:31723695" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032642 ; owl:annotatedTarget "An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032643 ; owl:annotatedTarget "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032645 ; owl:annotatedTarget "Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei)." . [] oboInOwl:hasDbXref "PMID:21526966" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032646 ; owl:annotatedTarget "Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "LAEVULINIC ACID" . [] oboInOwl:hasDbXref , "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032647 ; owl:annotatedTarget "Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris." . [] oboInOwl:hasDbXref "PMID:29537990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032648 ; owl:annotatedTarget "The presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus." . [] oboInOwl:hasDbXref "PMID:9916191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032649 ; owl:annotatedTarget "A type of flat-foot characterized by hindfoot abductovalgus, metatarsus adductus, and Achilles tendon shortening. The predominant radiographic findings include forefoot adduction with lateral subluxation of the navicular on the talus and heel valgus. Very abnormal shoe wear is noted on the medial side. Calluses occurunder the metatarsal heads and thehead of the plantar-flexed talus." . [] oboInOwl:hasDbXref "PMID:31892365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032650 ; owl:annotatedTarget "Increased concentration of glial fibrillary acidic protein in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:31892365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032651 ; owl:annotatedTarget "Increased concentration of chitinase-3-like protein 1 in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:31892365" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032652 ; owl:annotatedTarget "Increased concentration of chitotriosidase 1 in cerebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:28088395" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032653 ; owl:annotatedTarget "An abnormal increase in the molar ratio of lactate to pyruvate in the blood circulation." . [] oboInOwl:hasDbXref "PMID:11069434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032654 ; owl:annotatedTarget "Flow-mediated dilatation is a noninvasive tests of endothelial function that leverages ultrasound to measure arterial diameter and its response to an increase in shear stress, which normally causes endothelium-dependent dilatation. This term pertains to an abnormal reduction in the magnitude of dilatation. Flow-mediated dilatation is usually measured at the brachial artery." . [] oboInOwl:hasDbXref "PMID:27520363" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032655 ; owl:annotatedTarget "A reduced concentration of tocopherol in fat tissue." . [] oboInOwl:hasDbXref , "PMID:22742587", "PMID:24502379", "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032656 ; owl:annotatedTarget "A seizure lasting 30 minutes without fully regaining consciousness, provoked by fever (temperature greater than 38.0 degrees Celcius) at the time of seizure-onset, without a prior history of afebrile seizure and with no evidence of an acute central nervous system infection or insult." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "LEVA" . [] oboInOwl:hasDbXref "PMID:29288396", "PMID:30875019" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032657 ; owl:annotatedTarget "An abnormal increase in the level of globotriaosylsphingosine (Lyso-Gb3) in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032658 ; owl:annotatedTarget "Status epilepticus with prominent motor signs during the prolonged seizure." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032659 ; owl:annotatedTarget "A type of status epilepticus without prominent motor symptoms and in the presence of coma." . [] oboInOwl:hasDbXref , "PMID:22528274", "PMID:26336950", "PMID:26900382", "PMID:9924914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032660 ; owl:annotatedTarget """A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between. comment: source: seeAlso: Tonic-clonic status epilepticus""" . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032661 ; owl:annotatedTarget "A type of bilateral convulsive seizure of generalized onset that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032661 ; owl:annotatedTarget "Generalised convulsive status epilepticus" . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032662 ; owl:annotatedTarget "A type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032662 ; owl:annotatedTarget "Focal-onset seizure evolving into generalised convulsive status epilepticus" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032662 ; owl:annotatedTarget "Secondarily generalised convulsive status epilepticus" . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032663 ; owl:annotatedTarget "Status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "Laevulinsaeure" . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032664 ; owl:annotatedTarget "A type of focal motor status epilepticus characterized by continuous neck or body rotation and conjugate gaze deviation in a direction contralateral to the responsible epileptic focus. This includes some forms of tonic status epilepticus." . [] oboInOwl:hasDbXref , "PMID:21070217", "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032665 ; owl:annotatedTarget "A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032666 ; owl:annotatedTarget "Status epilepticus characterized by continuous hyperkinetic proximal limb or axial muscles producing irregular sequential ballistic movements such as pedaling pelvic thrusting, thrashing, or rocking movements." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032667 ; owl:annotatedTarget "A type of motor status epilepticus with repeating bilateral sudden brief (less than 100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032668 ; owl:annotatedTarget "A type of myoclonic status epilepticus in the absence of coma." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032669 ; owl:annotatedTarget "A type of myoclonic status epilepticus in the presence of coma." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032670 ; owl:annotatedTarget "Tonic status epilepticus is a type of status epilepticus characterized by focal or bilateral limb stiffening or elevation, which may be electrographically generalized or focal." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032671 ; owl:annotatedTarget "A type of status epilepticus without prominent motor symptoms in the absence of coma." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032672 ; owl:annotatedTarget "Autonomic status epilepticus is a type of non-convulsive status epilepticus without coma with prominent autonomic features regardless of whether it is electrographically generalized or focal." . [] oboInOwl:hasDbXref , "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032673 ; owl:annotatedTarget "Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "Levulinsaeure" . [] oboInOwl:hasDbXref "PMID:10471461" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032674 ; owl:annotatedTarget "A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occured owing to an injury of the skin. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032674 ; owl:annotatedTarget "Skin wound" . [] oboInOwl:hasDbXref "PMID:30475656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032675 ; owl:annotatedTarget "A cutaneous wound that is proceeding through an orderly and timely reparative process that results in sustained restoration of the anatomic and functional integrity of the skin." . [] oboInOwl:hasDbXref "PMID:8166487" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032676 ; owl:annotatedTarget "A cutaneous wound that has failed to proceed through the orderly and timely process to produce an atomic and functional integrity, or proceeded through the repair process without establishing a sustained anatomic and functional result." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032677 ; owl:annotatedTarget "A generalized motor seizure is a type of generalized-onset seizure with predominantly motor (involving musculature) signs. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement." . [] oboInOwl:hasDbXref "PMID:19469840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032678 ; owl:annotatedTarget "An eyelid myoclonia seizure is a type of generalized myoclonic seizure which may or may not be associated with loss of awareness." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032679 ; owl:annotatedTarget "A type of focal-onset seizure characterized by non-motor signs or symptoms (or behaviour arrest) as its initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032680 ; owl:annotatedTarget "A focal cognitive seizure involves an alteration in a cognitive function (which can be a deficit or a positive phenomenon such as forced thought), which occurs at seizure onset. To be classified as a focal cognitive seizure, the change in cognitive function should be specific and out of proportion to other relatively unimpaired aspects of cognition, because all cognition is impaired in a focal impaired awareness seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032681 ; owl:annotatedTarget "A focal aware cognitive seizure during which awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032682 ; owl:annotatedTarget "A focal non-motor seizure in which awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "beta-acetylpropionic acid" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032684 ; owl:annotatedTarget "A focal cognitive seizure with auditory agnosia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032685 ; owl:annotatedTarget "A focal cognitive seizure characterized by auditory agnosia as the initial semiological manifestation. For example a person may hear a ringing sound, but may not connect this with the concept that the sound is from a telephone ringing." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032686 ; owl:annotatedTarget "A focal cognitive seizure with memory impairment characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:17444534" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032687 ; owl:annotatedTarget "A focal cognitive seizure characterized by transient memory impairment as the initial semiological manifestation whilst other cognitive functions and awareness are preserved at seizure onset. The memory impairment may be an inability to recall events occurring prior to the seizure (retrograde amnesia), or failure to encode new memories for events occurring during the seizure (anterograde amnesia)." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032688 ; owl:annotatedTarget "A focal cognitive seizure with dissociation characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032689 ; owl:annotatedTarget "A focal cognitive seizure characterized by an experience of being disconnected from, though aware of, self or environment as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032690 ; owl:annotatedTarget "A focal cognitive seizure with dyscalculia and or acalculia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032691 ; owl:annotatedTarget "A focal cognitive seizure characterized by dyscalculia / acalculia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032692 ; owl:annotatedTarget "A focal cognitive seizure characterized by forced thinking as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032693 ; owl:annotatedTarget "A focal cognitive seizure characterized by neglect as the initial semiological manifestation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "gamma-ketovaleric acid" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032694 ; owl:annotatedTarget "A focal cognitive seizure characterized by dyslexia / alexia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032696 ; owl:annotatedTarget "A focal cognitive seizure characterized by receptive dysphasia / aphasia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032697 ; owl:annotatedTarget "A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032698 ; owl:annotatedTarget "A focal cognitive seizure characterized by conduction dysphasia / aphasia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032699 ; owl:annotatedTarget "A focal cognitive seizure characterized by dysgraphia / agraphia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032700 ; owl:annotatedTarget "A focal cognitive seizure characterized by left-right confusion as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032701 ; owl:annotatedTarget "A focal cognitive seizure characterized by anomia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032702 ; owl:annotatedTarget "A focal cognitive seizure characterized by expressive dysphasia / aphasia as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032704 ; owl:annotatedTarget "A focal cognitive seizure with illusion characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032705 ; owl:annotatedTarget "A focal cognitive seizure with forced thinking characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "gamma-ketovaleric acid" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032706 ; owl:annotatedTarget "A focal cognitive seizure with left-right confusion characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032707 ; owl:annotatedTarget "A focal cognitive seizure with dyslexia / alexia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032708 ; owl:annotatedTarget "A focal cognitive seizure with anomia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032709 ; owl:annotatedTarget "A focal cognitive seizure with dysgraphia / agraphia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032710 ; owl:annotatedTarget "A focal cognitive seizure with receptive dysphasia / aphasia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032711 ; owl:annotatedTarget "A type of focal clonic seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032712 ; owl:annotatedTarget "A type of focal motor seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032713 ; owl:annotatedTarget "A focal motor seizure with version characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032714 ; owl:annotatedTarget "A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032715 ; owl:annotatedTarget "A type of focal motor seizure (it commences in one hemisphere) involving bilateral muscle groups rapidly at seizure onset." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "levulic acid" . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032716 ; owl:annotatedTarget "A focal non-motor seizure characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032717 ; owl:annotatedTarget "A focal motor seizure with dystonia characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032718 ; owl:annotatedTarget "A focal motor seizure in which the initial semiological manifestation is the sustained contraction of both agonist and antagonist muscles producing athetoid or twisting movements, which produces abnormal postures." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032719 ; owl:annotatedTarget "A focal motor seizure with dysarthria / anarthria characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032720 ; owl:annotatedTarget "A type of focal motor seizure characterized by difficulty with articulation of speech, due to impaired coordination of muscles involved in speech sound production as the initial semiological manifestation. Receptive and expressive language functions are intact, however speech is poorly articulated and is less intelligible." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032721 ; owl:annotatedTarget "A focal motor seizure characterized by weakness or complete paralysis of a muscle or group of muscles as the initial semiological manifestation." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032722 ; owl:annotatedTarget "A type of focal tonic seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032723 ; owl:annotatedTarget "A focal motor seizure with dystonia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032724 ; owl:annotatedTarget "A focal tonic seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032725 ; owl:annotatedTarget "A type of focal clonic seizure during which awareness is partially or fully impaired at some point in the seizure." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "(2,5-Dioxo-4-imidazolidinyl)urea" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45630 ; owl:annotatedTarget "levulinic acid" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032726 ; owl:annotatedTarget "A focal hyperkinetic seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032727 ; owl:annotatedTarget "Focal emotional seizure with agitation is characterized by the presence of psychomotor agitation as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032728 ; owl:annotatedTarget "A focal atonic seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032729 ; owl:annotatedTarget "Focal emotional seizure with pleasure is characterized by the presence of a positive emotional experience with pleasure, bliss, joy, enhanced personal well-being, heightened self-awareness or ecstasy." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032730 ; owl:annotatedTarget "A focal myoclonic seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032731 ; owl:annotatedTarget "A type of focal hypermotor seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032732 ; owl:annotatedTarget "A focal motor seizure with paresis / paralysis characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032733 ; owl:annotatedTarget "A focal motor seizure with dysarthria / anarthria characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032734 ; owl:annotatedTarget "A focal emotional seizure during which awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032735 ; owl:annotatedTarget "Focal emotional seizure with anger in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032736 ; owl:annotatedTarget "Focal emotional seizure with anger is characterized by the presence of anger, as an expressed or observed emotion, at the outset of the seizure. It may be accompanied by aggressive behaviour." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032737 ; owl:annotatedTarget "Focal emotional seizure with paranoia is characterized by the presence of paranoia as an expressed or observed emotion at the outset of the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032738 ; owl:annotatedTarget "Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032739 ; owl:annotatedTarget "Focal emotional seizure with anxiety is characterized by the presence of anxiety, fear or panic as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures." . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032740 ; owl:annotatedTarget "A focal aware autonomic seizure has an initial manifestation pertaining to autonomic nervous system function, which may be objective (for example, pupillary dilation) or subjective (for example, nausea). As a type of focal aware seizure, awareness is retained throughout." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032740 ; owl:annotatedTarget "Localised autonomic seizures without altered responsiveness" . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032741 ; owl:annotatedTarget "Focal emotional seizure with paranoia in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032742 ; owl:annotatedTarget "Focal emotional seizure with pleasure in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032743 ; owl:annotatedTarget "Focal emotional seizure with crying (dacrystic)in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032744 ; owl:annotatedTarget "Focal emotional seizure with agitation in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032745 ; owl:annotatedTarget "Focal emotional seizure with laughing in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032746 ; owl:annotatedTarget "A focal emotional seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032747 ; owl:annotatedTarget "Focal emotional seizure with pleasure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032748 ; owl:annotatedTarget "Focal emotional seizure with anger in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032749 ; owl:annotatedTarget "Focal emotional seizure with paranoia in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032750 ; owl:annotatedTarget "Focal emotional seizure with laughing in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032751 ; owl:annotatedTarget "Focal emotional seizure with crying in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032752 ; owl:annotatedTarget "Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032753 ; owl:annotatedTarget "A focal emotional seizure with agitation in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032754 ; owl:annotatedTarget "A focal sensory seizure during which awareness is retained throughout the seizure." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "Gmelin:2121" . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032755 ; owl:annotatedTarget "A focal autonomic seizure characterised by impaired awareness at some point within the seizure." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032755 ; owl:annotatedTarget "Localised autonomic seizure with altered responsiveness" . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032756 ; owl:annotatedTarget "A focal cognitive seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032757 ; owl:annotatedTarget "A focal hemiclonic seizure in which awareness is retained throughout." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032758 ; owl:annotatedTarget "A type of focal myoclonic seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032759 ; owl:annotatedTarget "A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation as its first clinical manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032760 ; owl:annotatedTarget "A seizure characterized by sensations of feeling hot or cold as its first clinical manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032761 ; owl:annotatedTarget "A focal autonomic seizure with pallor / flushing characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032762 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by changes of the skin as the initial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032763 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by pupillary dilatation or contraction as the initial semiological feature." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydrogen(tetraoxidosulfate)(1-)" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032764 ; owl:annotatedTarget "A type of focal autonomic seizure characterised by penile erection as the intial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032765 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by an urge to unripe or defecate as the initial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032766 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by changes in respiratory rate as the initial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032768 ; owl:annotatedTarget "A focal autonomic seizure with pupillary dilation / constriction characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032769 ; owl:annotatedTarget "An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032770 ; owl:annotatedTarget "A focal autonomic seizure with erection characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032771 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by lacrimation as the initial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032772 ; owl:annotatedTarget "A Focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032773 ; owl:annotatedTarget "A type of focal autonomic seizure characterized by changes in heart rate as the initial semiological feature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032774 ; owl:annotatedTarget "A focal autonomic seizure with urge to urinate / defecate characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydrogensulfate" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032775 ; owl:annotatedTarget "An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032776 ; owl:annotatedTarget "A focal autonomic seizure with lacrimation characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032777 ; owl:annotatedTarget "A focal autonomic seizure with pallor / flushing characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032778 ; owl:annotatedTarget "A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032779 ; owl:annotatedTarget "A focal autonomic seizure with pupillary dilation / constriction characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032780 ; owl:annotatedTarget "A focal autonomic seizure with erection characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032781 ; owl:annotatedTarget "A focal autonomic seizure with urge to urinate / defecate characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032782 ; owl:annotatedTarget "A focal autonomic seizure with lacrimation characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032783 ; owl:annotatedTarget "A focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032784 ; owl:annotatedTarget "An autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydrogensulfate(1-)" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032785 ; owl:annotatedTarget "A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:21788614", "PMID:23599387" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032786 ; owl:annotatedTarget "A migrating focal seizure is a seizure that involves different body parts, usually without overlap, in a consecutive manner so that the offset of a seizure in one part coincides with its onset in another, even shifting multiple times between the sides of the body. They can be associated with autonomic manifestations." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032787 ; owl:annotatedTarget "A focal sensory seizure in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032788 ; owl:annotatedTarget "A focal autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032789 ; owl:annotatedTarget "A focal behavior arrest seizure characterised by retained awareness throughout the seizure." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032789 ; owl:annotatedTarget "Focal aware behaviour arrest seizure" . [] oboInOwl:hasDbXref "PMID:20196795", "PMID:23739099", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032790 ; owl:annotatedTarget "A focal behavior arrest seizure characterised by impaired awareness at some point during the seizure." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032790 ; owl:annotatedTarget "Focal impaired awareness behaviour arrest seizure" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032791 ; owl:annotatedTarget "A focal cognitive seizure with anomia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032792 ; owl:annotatedTarget "A tonic seizure is a type of motor seizure characterised by unilateral or bilateral limb stiffening or elevation, often with neck stiffening." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydrogentetraoxosulfate(1-)" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032793 ; owl:annotatedTarget "A focal cognitive seizure with receptive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032794 ; owl:annotatedTarget "A myoclonic seizure is a type of motor seizure characterised by sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032795 ; owl:annotatedTarget "A generalized myoclonic-tonic-clonic seizure is a type of generalized motor seizure characterised by a single or multiple jerks of limbs bilaterally, followed by tonic and clonic phases. The initial jerks can be considered to be either a brief period of clonus or myoclonus." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032795 ; owl:annotatedTarget "generalised onset myoclonic-tonic-clonic seizure" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032796 ; owl:annotatedTarget "A focal cognitive seizure with left-right confusion characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032797 ; owl:annotatedTarget "Seizures characterized by olfactory phenomena at onset - usually an odor, which is often unpleasant." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032798 ; owl:annotatedTarget "A focal cognitive seizure with neglect characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032799 ; owl:annotatedTarget "A focal hemiclonic seizure in which awareness is impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032800 ; owl:annotatedTarget "A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032801 ; owl:annotatedTarget "A focal cognitive seizure with memory impairment characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydrogentetraoxosulfate(VI)" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032802 ; owl:annotatedTarget "A focal cognitive seizure with dyscalculia / acalculia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032803 ; owl:annotatedTarget "A focal cognitive seizure with dysgraphia / agraphia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032804 ; owl:annotatedTarget "A focal sensory seizure with olfaction in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032805 ; owl:annotatedTarget "A focal sensory seizure with vestibular features in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032806 ; owl:annotatedTarget "A focal sensory seizure with visual features in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:33522601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032807 ; owl:annotatedTarget "A seizure occurring within the neonatal period (28 days beyond the full term date)." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032808 ; owl:annotatedTarget "Neonatal seizure is a seizure type that occurs in neonatal period and is characterized by an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end. This event can be associated or not with a clinical manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032809 ; owl:annotatedTarget "Neonatal electro-clinical seizure is an electrographic event occurring in neonatal period and coupled with a clinical manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032810 ; owl:annotatedTarget "A seizure characterized by a sensation in the head such as light-headedness or headache as its first clinical manifestation." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032811 ; owl:annotatedTarget "Neonatal electrographic only seizure is an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end, which is not associated with a clinical manifestation." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "hydroxidotrioxidosulfate(1-)" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032813 ; owl:annotatedTarget "Neonatal electro-clinical motor seizure is a type of neonatal electro-clinical seizure with predominant motor features." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032814 ; owl:annotatedTarget "Neonatal electro-clinical clonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups; it can be symmetric or asymmetric." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032815 ; owl:annotatedTarget "Neonatal electro-clinical myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal)." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032816 ; owl:annotatedTarget "Neonatal multifocal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at multiple sites." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032817 ; owl:annotatedTarget "Neonatal focal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) which occurs focally." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032818 ; owl:annotatedTarget "Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is unilateral regularly repeating jerking involving the same muscle groups." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032819 ; owl:annotatedTarget "Neonatal bilateral clonic seizure is a type of neonatal electro-clinical clonic seizure where the clonic jerking is bilateral." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032820 ; owl:annotatedTarget "Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups, which occurs at multiple sites." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032821 ; owl:annotatedTarget "Neonatal electro-clinical tonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a sustained increase in muscle tone, usually focal, that can be unilateral or bilateral, and lasting a few seconds to minutes." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032822 ; owl:annotatedTarget "Neonatal electro-clinical non-motor autonomic seizure is a type of neonatal electro-clinical seizure with predominant features of autonomic alterations, involving cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor, and thermoregulatory functions. May present as apnea." . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "2,5-Dioxo-4-imidazolidinyl-urea" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "HSO4(-)" . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032823 ; owl:annotatedTarget "Neonatal electro-clinical non-motor seizure with behavior arrest is a type of neonatal electro-clinical seizure characterized by an arrest of activities, freezing, immobilization, with or without apnea and/or other autonomic manifestations." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032823 ; owl:annotatedTarget "Neonatal electro-clinical seizure with behaviour arrest" . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032824 ; owl:annotatedTarget "Neonatal focal tonic seizure is a type of neonatal electro-clinical tonic seizure with a focal sustained increase in muscle tone, lasting a few seconds to minutes." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032825 ; owl:annotatedTarget "Neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic signs, often changing lateralization within or between seizures." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032826 ; owl:annotatedTarget "Focal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic focal signs, often changing lateralization within or between seizures." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032827 ; owl:annotatedTarget "Multifocal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic multifocal signs." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032828 ; owl:annotatedTarget "Neonatal bilateral symmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body symmetrically." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032829 ; owl:annotatedTarget "Neonatal electro-clinical motor seizure with automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, and in association with other features." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032830 ; owl:annotatedTarget "Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with coordinated motor activity, typically oral, usually with impaired awareness, occurring at both sides of the body asymmetrically." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032831 ; owl:annotatedTarget "Neonatal bilateral asymmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body but asymmetrically." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "HYDROGEN SULFATE" . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032832 ; owl:annotatedTarget "Neonatal bilateral asymmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body asymmetrically." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032833 ; owl:annotatedTarget "A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: grimacing, head nodding, or subtle eye movements. May occur in clusters." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032834 ; owl:annotatedTarget "Neonatal seizure with bilateral asymmetric automatisms is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at one side of the body." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032835 ; owl:annotatedTarget "Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at both sides of the body symmetrically." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032836 ; owl:annotatedTarget "Neonatal bilateral symmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body symmetrically." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032837 ; owl:annotatedTarget "Asymmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting asymmetrically with a variety of clinical and electrographic signs, often changing lateralization within or between seizures." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032838 ; owl:annotatedTarget "Neonatal unilateral epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs at one side of the body." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032839 ; owl:annotatedTarget "Symmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting symmetrically but with a variety of clinical and electrographic signs." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032840 ; owl:annotatedTarget "Neonatal bilateral symmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs symmetrically at both sides of the body." . [] oboInOwl:hasDbXref "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032841 ; owl:annotatedTarget "Neonatal bilateral asymmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs asymmetrically at both sides of the body." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_45696 ; owl:annotatedTarget "[SO3(OH)](-)" . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032842 ; owl:annotatedTarget "A type of epileptic spasm of generalized onset." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032843 ; owl:annotatedTarget "A type of epileptic spasm of focal onset." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032844 ; owl:annotatedTarget "A type of focal-onset epileptic spasm in which awareness is impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032845 ; owl:annotatedTarget "A type of focal-onset epileptic spasm in which awareness is preserved throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032846 ; owl:annotatedTarget "A type of focal motor seizure characterized by a sudden interruption in normal tonic muscle activity lasting 500 ms or less, without evidence of preceding myoclonus as the initial semiological manifestation. The interruption in muscle tone is briefer than seen in a focal atonic seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032847 ; owl:annotatedTarget "Focal seizure characterized at onset by clonic movements affecting half of the face with impairment of awareness in which awareness is impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032848 ; owl:annotatedTarget "A focal cognitive seizure with neglect characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032849 ; owl:annotatedTarget "Aphasic status epilepticus is a type of focal non-convulsive status epilepticus without coma characterized by a cognitive (rather than motor) language deficit." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032850 ; owl:annotatedTarget "A focal cognitive seizure with expressive dysphasia / aphasia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032851 ; owl:annotatedTarget "A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis." . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46629 ; owl:annotatedTarget "OXO GROUP" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032852 ; owl:annotatedTarget "A focal cognitive seizure with conduction dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032853 ; owl:annotatedTarget "A focal sensory seizure with hot-cold sensations in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032854 ; owl:annotatedTarget "Focal seizure characterized at onset by clonic movements affecting half of the face with retained awareness throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032855 ; owl:annotatedTarget "Generalised myoclonic-tonic-clonic seizure provoked by flashing or flickering light." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032856 ; owl:annotatedTarget "A type of focal bilateral motor seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032857 ; owl:annotatedTarget "A focal motor seizure with negative myoclonus characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032858 ; owl:annotatedTarget "A focal motor seizure with negative myoclonus characterized by impairement of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032859 ; owl:annotatedTarget "A focal motor seizure with paresis / paralysis characterized by impaired awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032860 ; owl:annotatedTarget "Generalized non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically generalized. It is a prolonged absence seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032861 ; owl:annotatedTarget "Focal non-convulsive status epilepticus with impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness is impaired." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46629 ; owl:annotatedTarget "oxo" . [] oboInOwl:hasDbXref "PMID:17116038", "PMID:25667883", "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032862 ; owl:annotatedTarget "A type of focal motor status epilepticus characterized by prolonged ictal paresis or inhibitory motor seizures." . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032863 ; owl:annotatedTarget "Typical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged typical absence seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032864 ; owl:annotatedTarget "A type of focal sensory seizure with auditory features during which awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032865 ; owl:annotatedTarget "Myoclonic absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged myoclonic absence seizure. Myoclonic absence status epilepticus consists of proximal, predominantly upper extremity myoclonic jerks corresponding with 3 Hz spike-wave discharges in the EEG." . [] oboInOwl:hasDbXref "PMID:11967176", "PMID:26336950", "PMID:2912713" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032866 ; owl:annotatedTarget "A type of focal motor status epilepticus characterized by repetitive and rapid saccades, in association with epileptic discharges." . [] oboInOwl:hasDbXref "PMID:19817823" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032867 ; owl:annotatedTarget "Refractory status epilepticus is defined as status epilepticus continuing despite two appropriately selected and dosed antiepileptic drugs, including a benzodiazepine." . [] oboInOwl:hasDbXref "PMID:21914716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032868 ; owl:annotatedTarget "Super-refractory status epilepticus is defined as refractory status epilepticus continuing for 24 h or more following initiation of anesthetic medications, including cases in which seizure control is attained after induction of anesthetic drugs but recurs on weaning the patient off the anesthetic agent." . [] oboInOwl:hasDbXref "PMID:26336950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032869 ; owl:annotatedTarget "Focal non-convulsive status epilepticus without impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness remains intact." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032870 ; owl:annotatedTarget "A focal cognitive seizure with dyslexia / alexia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032871 ; owl:annotatedTarget "A focal cognitive seizure with hallucination characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46629 ; owl:annotatedTarget "=O" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032872 ; owl:annotatedTarget "A focal cognitive seizure with illusion characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032873 ; owl:annotatedTarget "A seizure characterized by a sensation in the head such as light-headedness or headache." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032874 ; owl:annotatedTarget "A focal cognitive seizure with auditory agnosia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032876 ; owl:annotatedTarget "A focal cognitive seizure with conduction dysphasia / aphasia characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032877 ; owl:annotatedTarget "A seizure characterized by sensations of feeling hot and then cold." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032878 ; owl:annotatedTarget "A focal sensory seizure with cephalic sensation in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032879 ; owl:annotatedTarget "A focal cognitive epileptic seizure with dissociation at the onset of the seizure and with impairment of awareness at at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032880 ; owl:annotatedTarget "A focal sensory seizure with auditory features in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032882 ; owl:annotatedTarget "A focal cognitive seizure with deja vu / jamais vu characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032883 ; owl:annotatedTarget "A focal cognitive seizure with deja vu / jamais vu characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46662 ; owl:annotatedTarget "mineral" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032884 ; owl:annotatedTarget "A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move. Awareness is retained throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032885 ; owl:annotatedTarget "A focal cognitive seizure with hallucination characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032886 ; owl:annotatedTarget "A focal cognitive seizure with expressive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032887 ; owl:annotatedTarget "Generalized atonic seizure is a type of generalized motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1-2 s, involving head, trunk, jaw, or limb musculature." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032888 ; owl:annotatedTarget "A focal cognitive seizure with forced thinking characterized by impairment of awareness at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032889 ; owl:annotatedTarget "A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032890 ; owl:annotatedTarget "A focal sensory seizure with somatosensory features in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032891 ; owl:annotatedTarget "A focal motor seizure with version characterized by retained awareness throughout the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032892 ; owl:annotatedTarget "Seizure associated with a presumed or proven infection (excluding infection of the central nervous system) or inflammatory state without an alternative precipitant such as metabolic derangement, and regardless of the presence or absence of a fever." . [] oboInOwl:hasDbXref "PMID:12453597", "PMID:29935410" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032893 ; owl:annotatedTarget "Afebrile (less than 38.0 degrees Celcius), brief, and generalized seizures accompanying gastroenteritis without an alternative cause." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46662 ; owl:annotatedTarget "Minerale" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032894 ; owl:annotatedTarget "Any form of seizure occurring at the time of a fever (temperature at or above 38.0 degrees Celcius) without infection of the central nervous system, and without an alternative cause such as severe metabolic derangement, occurring at any age." . [] oboInOwl:hasDbXref "PMID:30078767", "PMID:9126059" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032895 ; owl:annotatedTarget "Any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38.0 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in people beyond the typical arrange of 3 months-6 years with no prior history of afebrile seizure." . [] oboInOwl:hasDbXref "PMID:11422340" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032896 ; owl:annotatedTarget "Seizure precipitated by listening to music or other complex sounds." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032897 ; owl:annotatedTarget "A focal sensory seizure with gustatory features in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:11580774", "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032898 ; owl:annotatedTarget "A focal seizure characterized at onset by coordinated motor activity. This often resembles a voluntary movement and may consist of an inappropriate continuation of preictal motor activity." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032899 ; owl:annotatedTarget "A type of focal automatism seizure characterized by orofacial automatisms at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032900 ; owl:annotatedTarget "A type of focal automatism seizure characterized by manual automatisms at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032901 ; owl:annotatedTarget "A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032902 ; owl:annotatedTarget "A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032903 ; owl:annotatedTarget "A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46662 ; owl:annotatedTarget "minerales" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032904 ; owl:annotatedTarget "A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032905 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary sexual behavior at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032906 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary head nodding at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032907 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary undressing at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032908 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary undressing at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060", "PMID:28276064" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032909 ; owl:annotatedTarget "A focal seizure with automatism in which awareness is partially or fully impaired at some point during the seizure." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032910 ; owl:annotatedTarget "A type of focal automatism seizure during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032911 ; owl:annotatedTarget "A type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032912 ; owl:annotatedTarget "A type of focal automatism seizure characterized by manual automatisms at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032913 ; owl:annotatedTarget "A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46662 ; owl:annotatedTarget "minerals" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032914 ; owl:annotatedTarget "A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032915 ; owl:annotatedTarget "A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032916 ; owl:annotatedTarget "A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032917 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary sexual behavior at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032918 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by orofacial automatisms at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032919 ; owl:annotatedTarget "A type of focal automatism seizure characterized by involuntary head nodding at onset and during which awareness is fully retained throughout." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032920 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by manual automatisms at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032921 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032922 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by inappropriate continuation of pre-seizure movement or behavior at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032923 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "4-ureido-2,5-imidazolidinedione" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46662 ; owl:annotatedTarget "mineraux" . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032924 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive words, phrases, or brief sentences at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032925 ; owl:annotatedTarget "A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by involuntary sexual behavior at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032926 ; owl:annotatedTarget "A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary head nodding at onset." . [] oboInOwl:hasDbXref "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032927 ; owl:annotatedTarget "A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary undressing at onset." . [] oboInOwl:hasDbXref "PMID:31182505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032928 ; owl:annotatedTarget "Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases." . [] oboInOwl:hasDbXref "PMID:8571951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032930 ; owl:annotatedTarget "Concentric rings around the chondrocytes." . [] oboInOwl:hasDbXref "PMID:28431198" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032932 ; owl:annotatedTarget "An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma)." . [] oboInOwl:hasDbXref "PMID:12629006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032933 ; owl:annotatedTarget "An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist." . [] oboInOwl:hasDbXref "PMID:19225307", "PMID:22929030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032934 ; owl:annotatedTarget "A spontaneous cerebrospinal fluid leak (SCSFL) is a spontaneous and unexplained leak of the cerebrospinal fluid from the dura surrounding either the brain (cranial leak) or spine (spinal leak)." . [] oboInOwl:hasDbXref "PMID:19682623" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032935 ; owl:annotatedTarget "Grayish, polygonal pattern of opacities with intervening clear zones across the central cornea that resembles crocodile skin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46701 ; owl:annotatedTarget "pyrrolidinemonocarboxylic acids" . [] oboInOwl:hasDbXref "PMID:15487537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032936 ; owl:annotatedTarget "Unintentional reexperiencing a traumatic event comprising symptoms are usually sensory impressions and emotional responses from the trauma that appear to lack a time perspective and a context." . [] oboInOwl:hasDbXref "PMID:30293686" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032937 ; owl:annotatedTarget "After suffering psychological trauma, people can repeatedly experience sensory-perceptual impressions of the event, which intrude involuntarily into consciousness. These intrusive memories typically take the form of visual images (e.g., pictures in the mind's eye), but can also include sounds, smells, tastes and bodily sensations, and come with a range of negative emotions associated with the hotspots in the trauma memory." . [] oboInOwl:hasDbXref "PMID:17431265" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032938 ; owl:annotatedTarget "Recurrent distressing dreams in which the content and/or affect of the dream are related to the traumatic event or events." . [] oboInOwl:hasDbXref "PMID:26611143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032939 ; owl:annotatedTarget "Marked physiological reactions to internal or external cues that symbolize or resemble an aspect of the traumatic event(s)." . [] oboInOwl:hasDbXref "PMID:25994026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032940 ; owl:annotatedTarget "A disruption and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. Clinical presentations of dissociation may include a wide variety of symptoms, including experiences of depersonalization, derealisation, emotional numbing, flashbacks of traumatic events, absorption, amnesia, voice hearing, interruptions in awareness, and identity alteration." . [] oboInOwl:hasDbXref "PMID:17431265" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032941 ; owl:annotatedTarget "Intense or prolonged psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event or events." . [] oboInOwl:hasDbXref "PMID:17431265" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032942 ; owl:annotatedTarget "Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032945 ; owl:annotatedTarget "Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032946 ; owl:annotatedTarget "Histopathological findings of inflammation of the renal interstitium involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032947 ; owl:annotatedTarget "Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46723 ; owl:annotatedTarget "phosphate minerals" . [] oboInOwl:hasDbXref "PMID:22449945" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032948 ; owl:annotatedTarget "The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic." . [] oboInOwl:hasDbXref , "PMID:21804087" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032949 ; owl:annotatedTarget "The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits." . [] oboInOwl:hasDbXref "PMID:23101152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032950 ; owl:annotatedTarget "Abnormal structure or form of the lumen (opening) of kidney tubules." . [] oboInOwl:hasDbXref "PMID:21436288", "PMID:29273157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032951 ; owl:annotatedTarget "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells." . [] oboInOwl:hasDbXref "PMID:7906246" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032952 ; owl:annotatedTarget "A type of renal tubular atrophy in which the tubules show thick tubular basement membranes lined by small cuboidal or flat cells. Generally accompanied by fibrosis." . [] oboInOwl:hasDbXref , "PMID:29273157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032954 ; owl:annotatedTarget "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage." . [] oboInOwl:hasDbXref , "PMID:27884285" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032956 ; owl:annotatedTarget "Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis." . [] oboInOwl:hasDbXref "PMID:16362157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032957 ; owl:annotatedTarget "The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria." . [] oboInOwl:hasDbXref "PMID:13171348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032958 ; owl:annotatedTarget "The presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032959 ; owl:annotatedTarget "Birefringent calcium- and oxalate-containing casts located within the tubuli of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032960 ; owl:annotatedTarget "Purple and finely granular/laminated calcium- and phosphate-containing casts located within the tubuli of the kidney." . [] oboInOwl:hasDbXref , "PMID:18776117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032963 ; owl:annotatedTarget "A renal cyst characterized by epithelium lined space (squamous/columnar) with septations." . [] oboInOwl:hasDbXref "PMID:25045326", "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032964 ; owl:annotatedTarget "The presence of uric acid crystals in the urine." . [] oboInOwl:hasDbXref , "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032965 ; owl:annotatedTarget "Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation. It is rarely recognized radiographically in adults and is infrequently seen on CT scans. It appears as perivascular lucent or low attenuating halos and small cysts." . [] oboInOwl:hasDbXref , "PMID:18195376", "PMID:4014865", "PMID:7976869" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032966 ; owl:annotatedTarget "A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones." . [] oboInOwl:hasDbXref , "PMID:1395384", "PMID:18195376", "PMID:8370825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032967 ; owl:annotatedTarget "Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis." . [] oboInOwl:hasDbXref , "PMID:10524809", "PMID:18195376", "PMID:7972745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032968 ; owl:annotatedTarget "Abnormal retention of gas within a lung or part of a lung, as a result of airway obstuction of abnormalities in lung compliance. In the classic presentation, the lung will appear normal at inspiration, but on exhalation, the diseased portions of the lung which have lost connective tissue recoil will remain lucent while the healthy portions of the lung will become more dense due to atelectasis. This helps distinguish it from mosaic attenuation due to patchy fibrosis, as occurs with nonspecific interstitial pneumonia, and in early usual interstitial pneumonitis (the hallmark imaging diagnosis of interstitial lung disease) in which there is no change with inspiration and expiration." . [] oboInOwl:hasDbXref , "PMID:18195376", "PMID:3786716" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032969 ; owl:annotatedTarget "Distortion of the bronchial airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchial dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as cysts." . [] oboInOwl:hasDbXref , "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0032970 ; owl:annotatedTarget "Distortion of the bronchiolar airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchiolar dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as microcysts." . [] oboInOwl:hasDbXref , "PMID:18195376", "PMID:3864189" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032971 ; owl:annotatedTarget "CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46761 ; owl:annotatedTarget "Dipeptide" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032971 ; owl:annotatedTarget "CT halo sign" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032972 ; owl:annotatedTarget "A nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032973 ; owl:annotatedTarget "Abnormal type or counts of nucleated immune cells and acellular components in bronchoalveolar lavage (BAL) fluid. BAL us performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. BAL is commonly used to inform the differential diagnosis of interstitial lung disease or to monitor therapeutic interventions." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:10678650", "PMID:3396403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032974 ; owl:annotatedTarget "Deviation from the commonly in healthy people observe cellular distribution. Normal ranghes are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:10678650", "PMID:3396403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032976 ; owl:annotatedTarget "Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:10678650", "PMID:3396403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032977 ; owl:annotatedTarget "Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:11757629" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032978 ; owl:annotatedTarget "Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions." . [] oboInOwl:hasDbXref , "PMID:16871595", "PMID:23678356", "PMID:25515792", "PMID:28166761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032979 ; owl:annotatedTarget "Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP)." . [] oboInOwl:hasDbXref , "PMID:26375475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032980 ; owl:annotatedTarget "Significantly decreased level or failed detection of surfactant protein C in broncho-alveolar lavage fluid. Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-C may result of surfactant metabolism dysfunction and is also observed in patients with other diffuse parenchymal lung diseaes, pathogenetically related to the alveolar surfactant region." . [] oboInOwl:hasDbXref , "PMID:26375475" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032981 ; owl:annotatedTarget "Significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46761 ; owl:annotatedTarget "Dipeptid" . [] oboInOwl:hasDbXref , "PMID:10414267", "PMID:15908556", "PMID:22553298" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032983 ; owl:annotatedTarget "CT finding of central ground-glass opacity surrounded by denser consolidation of crescentic shape (forming more than three-fourths of a circle) or complete ring of at least 2 mm in thicknes. A rare sign, it was initially reported to be specific for cryptogenic organizing pneumonia, but was subsequently described in patients with paracoccidioidomycosis." . [] oboInOwl:hasDbXref , "ISBN:0412792702." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032984 ; owl:annotatedTarget "Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:3740951" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032985 ; owl:annotatedTarget "Accumulation of inhaled, nondigestable particles in macrophages." . [] oboInOwl:hasDbXref , "ISBN:0412792702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032986 ; owl:annotatedTarget "In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits." . [] oboInOwl:hasDbXref , "ISBN:0412792702", "PMID:10678650", "PMID:3396403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032987 ; owl:annotatedTarget "Usually, eosinophils make up less than 0.5% of all cells found in the broncho-alveloar lavage fluid. But in eosinophilic lung disease, the eosinophil cell proportion typically represents more than 25%. Comment: An elevated level of eosinophil cells are also a result of infections, or an allergic reaction or can be drug-induced." . [] oboInOwl:hasDbXref "PMID:26709421" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032988 ; owl:annotatedTarget "The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032990 ; owl:annotatedTarget "Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032990 ; owl:annotatedTarget "Localised pulmonary haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032991 ; owl:annotatedTarget "An abnormal form or number of the pulmonary fissures." . [] oboInOwl:hasDbXref , "PMID:24570004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032996 ; owl:annotatedTarget "Any deviation from the normal concentration of cystatin C in serum or plasma." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46761 ; owl:annotatedTarget "dipeptides" . [] oboInOwl:hasDbXref , "PMID:24570004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032997 ; owl:annotatedTarget "A decreased concentration of cystatin C in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:24570004" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032998 ; owl:annotatedTarget "A elevated concentration of cystatin C in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:25372274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0032999 ; owl:annotatedTarget "Abnormally high concentration of fecal porphyrins in feces." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0032999 ; owl:annotatedTarget "Increased faecal porphyrin" . [] oboInOwl:hasDbXref , "PMID:31680234" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033000 ; owl:annotatedTarget "Narrowing of the larynx, commonly occuring during viral respiratory tract infections, in particular in children, leads to symptoms such as hoarseness, a barking cough, stridor, and sometimes dyspnea and respiratory failure." . [] oboInOwl:hasDbXref "PMID:30828624" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033001 ; owl:annotatedTarget "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the larynx." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033001 ; owl:annotatedTarget "Laryngeal papillomas" . [] oboInOwl:hasDbXref "PMID:32309132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033002 ; owl:annotatedTarget "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on a bronchus." . [] oboInOwl:hasDbXref "PMID:32309132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033003 ; owl:annotatedTarget "A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the trachea." . [] oboInOwl:hasDbXref "PMID:17210977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033004 ; owl:annotatedTarget "Multiple verrucous lesions on the skin of the palm. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by human papillomavirus (HPV)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46767 ; owl:annotatedTarget "pyrrolidinecarboxylic acids" . [] oboInOwl:hasDbXref "PMID:17210977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033005 ; owl:annotatedTarget "Multiple verrucous lesions on the skin of the sole of the foot. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV)." . [] oboInOwl:hasDbXref , "PMID:28570160", "PMID:32364264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033006 ; owl:annotatedTarget "Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation." . [] oboInOwl:hasDbXref , "PMID:25489125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033007 ; owl:annotatedTarget "Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss." . [] oboInOwl:hasDbXref , "PMID:3327428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033009 ; owl:annotatedTarget "Abnormally high concentration of coproporphyrin 1 in feces." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033009 ; owl:annotatedTarget "Elevated faecal coproporphyrin 1" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033009 ; owl:annotatedTarget "High faecal coproporphyrin 1" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033009 ; owl:annotatedTarget "Increased faecal coproporphyrin 1" . [] oboInOwl:hasDbXref , "PMID:3327428" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033010 ; owl:annotatedTarget "Abnormally high concentration of coproporphyrin 3 in feces" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033010 ; owl:annotatedTarget "Elevated faecal coproporphyrin 3" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033010 ; owl:annotatedTarget "High faecal coproporphyrin 3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46773 ; owl:annotatedTarget "hydroxypyrrolidines" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033010 ; owl:annotatedTarget "Increased faecal coproporphyrin 3" . [] oboInOwl:hasDbXref "PMID:31839203" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033011 ; owl:annotatedTarget "Extreme width of the skull in the occipital region, with anterior narrowing and prognathism." . [] oboInOwl:hasDbXref , "PMID:18280810", "PMID:19602555" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033013 ; owl:annotatedTarget "Any deviation from the normal concentration of cortisol in saliva." . [] oboInOwl:hasDbXref , "PMID:18280810", "PMID:19602555" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033014 ; owl:annotatedTarget "Abnormally reduced concentration of cortisol in saliva." . [] oboInOwl:hasDbXref , "PMID:18280810", "PMID:19602555" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033015 ; owl:annotatedTarget "Abnormally elevated concentration of cortisol in saliva." . [] oboInOwl:hasDbXref "PMID:23762643" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033026 ; owl:annotatedTarget "A small circumscribed whitish change in the color of the oral mucosa that is neither elevated nor depressed." . [] oboInOwl:hasDbXref "PMID:25526100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033027 ; owl:annotatedTarget "A pebbly orange appearance of the fundus that is said to resemble the skin of an orange." . [] oboInOwl:hasDbXref , "PMID:15804705", "PMID:29796907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033028 ; owl:annotatedTarget "The presence autoantibodies in the serum that react to proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033028 ; owl:annotatedTarget "Anti-RNP-antibodies" . [] oboInOwl:hasDbXref , "PMID:20660402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033030 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react to the glomerular basement membrane." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46775 ; owl:annotatedTarget "N-alkylpyrrolidines" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033030 ; owl:annotatedTarget "Anti-GBM-antibody positivity" . [] oboInOwl:hasDbXref , "PMID:16818546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033031 ; owl:annotatedTarget "An extreme elevation of core body temperature above normal defined as a rectal temperature of 41.1 degrees Celsius (106 degrees Fahrenheit)." . [] oboInOwl:hasDbXref , "PMID:29938745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033032 ; owl:annotatedTarget "Applies to a sign or symptom that is induced by an abusive adult (usually a parent)." . [] oboInOwl:hasDbXref , "PMID:32270621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033033 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react to Anti-MDA5 (Anti-melanoma differentiation-associated proteine 5)." . [] oboInOwl:hasDbXref , "PMID:21713412", "PMID:27824549" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033034 ; owl:annotatedTarget "The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen." . [] oboInOwl:hasDbXref , "PMID:31760652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033035 ; owl:annotatedTarget "Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function." . [] oboInOwl:hasDbXref "PMID:28481653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033036 ; owl:annotatedTarget "Reduced level of nasal nitric oxide (nNO). Current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for nNO measurements recommend air aspiration via a nasal probe while the subject exhales through the mouth against resistance in order to maintain velum closure." . [] oboInOwl:hasDbXref , "PMID:31657698" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0033037 ; owl:annotatedTarget "A form of arthritis characterized by gradual involvement of several joints, with involvement of some joints occurring following partial or full resolution of arthritis in joints with an earlier onset." . [] oboInOwl:hasDbXref , "PMID:31858335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033038 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react to RNA-polymerase III." . [] oboInOwl:hasDbXref , "PMID:22796841", "PMID:26310038" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033039 ; owl:annotatedTarget "The presence of high titers of antigen-precipitating IgG in the serum." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "5-Ureido-2,4-imidazolidindione" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46787 ; owl:annotatedTarget "Loesungsmittel" . [] oboInOwl:hasDbXref , "PMID:31552434" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033040 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles." . [] oboInOwl:hasDbXref "PMID:22390970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033041 ; owl:annotatedTarget "Excessive or uncontrolled release of proinflammatory cytokines." . [] oboInOwl:hasDbXref "PMID:18755720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033042 ; owl:annotatedTarget "Any structural anomaly of the fetal part of the placenta, which is known as the chorion." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46787 ; owl:annotatedTarget "solvant" . [] oboInOwl:hasDbXref "PMID:26992676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033043 ; owl:annotatedTarget "Swelling of the chorionic villi owing to fluid accumulation." . [] oboInOwl:hasDbXref "PMID:27354457", "PMID:31737722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033044 ; owl:annotatedTarget "Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46787 ; owl:annotatedTarget "solvents" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033045 ; owl:annotatedTarget "Bipedal oedema" . [] oboInOwl:hasDbXref "PMID:28566412", "PMID:32509269" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033046 ; owl:annotatedTarget "Basophilic intracytoplasmic inclusions in macrophages. The inclusions have a small, round laminated appearance. Electron microscopy of Michaelis-Gutmann bodies exhibits partially digested bacteria." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033050 ; owl:annotatedTarget "Sore throat" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033050 ; owl:annotatedTarget "Throat discomfort" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033050 ; owl:annotatedTarget "Throat pain" . [] oboInOwl:hasDbXref "PMID:28631987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033051 ; owl:annotatedTarget "A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia." . [] oboInOwl:hasDbXref "PMID:23251092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033053 ; owl:annotatedTarget "Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges." . [] oboInOwl:hasDbXref "PMID:29416935" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033054 ; owl:annotatedTarget "A tremor-like cortical myoclonus. The tremulous movements are in fact small, high-frequency myoclonic jerks, induced by posture or action. They can be mild, but can also be more incapacitating. When present in the lower limbs, these may lead to gait disorders and even drop attacks. These tremor-like movements during action can be mistaken for essential tremor or epileptic seizures." . [] oboInOwl:hasDbXref , "NCIT:C121469", "PMID:26039846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033055 ; owl:annotatedTarget "Impaired ability to anticipate future events, implement instructions or goals, and develop appropriate steps ahead of time in order to carry out a task or activity." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033055 ; owl:annotatedTarget "Ineffective planning" . [] oboInOwl:hasDbXref , "NCIT:C121469", "PMID:26039846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033056 ; owl:annotatedTarget "Impaired ability to bring order to information, actions, or materials to achieve a goal or to follow an established organized routine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033056 ; owl:annotatedTarget "Impaired ability to organise" . [] oboInOwl:hasDbXref "PMID:26841934" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033057 ; owl:annotatedTarget "Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9." . [] oboInOwl:hasDbXref "PMID:17407100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033058 ; owl:annotatedTarget "Concentration of the complement component C7 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:10632667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033059 ; owl:annotatedTarget "Concentration of the complement component C6 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:23371790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033060 ; owl:annotatedTarget "Concentration of the complement component C5 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:19846852" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033061 ; owl:annotatedTarget "Elevated activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa." . [] oboInOwl:hasDbXref "PMID:31473062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033063 ; owl:annotatedTarget "A tendency to sleep less hours than usual while feeling well rested." . [] oboInOwl:hasDbXref "PMID:32606714" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033064 ; owl:annotatedTarget "Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC)." . [] oboInOwl:hasDbXref "PMID:30571025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033065 ; owl:annotatedTarget "The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol)." . [] oboInOwl:hasDbXref "PMID:30571025" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033066 ; owl:annotatedTarget "The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol)." . [] oboInOwl:hasDbXref "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0033067 ; owl:annotatedTarget "Cystine crystals precipitate as symmetrical hexagons, mostly aggregated, and are constantly birefringent. They are typical of patients with cystinuria, but to find them the urine pH must be lowered to 4.0 with glacial acetic acid and stored overnight at 4 degrees C." . [] oboInOwl:hasDbXref "PMID:8671802" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033068 ; owl:annotatedTarget "A variety of drugs may occasionally cause transient crystalluria, in isolation or in conjunction with other urinary abnormalities. Overdose, dehydration, or hypoalbuminaemia, which increases the unbound drug which is ultrafiltrated by the glomerulus, are the factors usally favoring the precipitation of crystals within the tubular lumina. In some cases, medication-induced crystalluria has a distinct phenotypic appearance. For instance, Sulphadiazine crystals appear as strongly birefringent 'shocks of wheat' or 'shells' with an amber colour. Acyclovir crystals are birefringent and needle-shaped, and when present in abundance give to urine a silky and opalescent macroscopic appearance." . [] oboInOwl:hasDbXref "PMID:21719792", "PMID:29359118" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033069 ; owl:annotatedTarget "An increased number of IgG4+ plasma cells in the interstitial space of the kidney." . [] oboInOwl:hasDbXref "NCIT:C121466", "PMID:26039846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033070 ; owl:annotatedTarget "Impaired ability to track awareness of the effect that one's behavior has on others and how it compares with standards or expectations for behavior." . [] oboInOwl:hasDbXref "NCIT:C121470", "PMID:26039846" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033071 ; owl:annotatedTarget "Impaired ability to keep track of one's problem-solving success or failure, and to identify and correct mistakes during performance of a goal." . [] oboInOwl:hasDbXref "PMID:9195521" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033073 ; owl:annotatedTarget "Intradermal urate crystal deposits appeared as small, superficial, pustule-like, whitish lesions. The lesions may be the focus of inflammatory episodes with increasing pain, swelling, and erythema of the intradermal tophi." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033073 ; owl:annotatedTarget "Urate tophi" . [] oboInOwl:hasDbXref "PMID:20651069" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033074 ; owl:annotatedTarget "Amelioration of anemia upon treatment with a steroid medication." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46818 ; owl:annotatedTarget "urate anion" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033074 ; owl:annotatedTarget "Prednisone-responsive anaemia" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033074 ; owl:annotatedTarget "Steroid-responsive anaemia" . [] oboInOwl:hasDbXref "PMID:12519407", "PMID:28932413" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033075 ; owl:annotatedTarget "A normal or elevated serum thyroid-stimulating hormone (TSH) level in the face of an elevation in circulating FT4 and/or FT3." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033075 ; owl:annotatedTarget "Inappropriately normal TSH" . [] oboInOwl:hasDbXref "PMID:30725738" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033076 ; owl:annotatedTarget "A deviation from the normal concentration of free thyroxine (T4) in the blood circulation. Circulating T4 is almost entirely bound to specific transport proteins such as thyroxine-binding globulin (TBG) but it is the unbound (free) fraction that is able to enter tissues and exert effects." . [] oboInOwl:hasDbXref "PMID:29935915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033081 ; owl:annotatedTarget "Failure to increase serum TSH levels in response to a TRH stimulation test." . [] oboInOwl:hasDbXref "PMID:29909962" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033083 ; owl:annotatedTarget "An elevated level of farnesol in the blood circulation." . [] oboInOwl:hasDbXref "PMID:30010909" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033085 ; owl:annotatedTarget "A count of antral follicles that is lower than normal for age." . [] oboInOwl:hasDbXref "PMID:32656532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033086 ; owl:annotatedTarget "A count of antral follicles that is higher than normal for age." . [] oboInOwl:hasDbXref "PMID:28546530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033087 ; owl:annotatedTarget "Fever that occurs at daily intervals." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:NSTRN_jmiller" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033088 ; owl:annotatedTarget "Urine valine level above the normal range." . [] oboInOwl:hasDbXref "PMID:32942769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033092 ; owl:annotatedTarget "The concentration of succinate in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033095 ; owl:annotatedTarget "Increased sulphur amino acid level in urine" . [] oboInOwl:hasDbXref "PMID:30830355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033101 ; owl:annotatedTarget "An abnormally increased level of aconitic acid in the urine." . [] oboInOwl:hasDbXref "PMID:7977470" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033102 ; owl:annotatedTarget "The femoral neck region shows medial metaphyseal beaking and a significant enlargement of the lesser trochanter (with some enlargement also of the greater trochanter), producing a monkey wrench (Swedish key) configuration of the proximal femur. A monkey wrench refers to a type of adjustable wrench with one fixed and one adjustable jaw at right angles to a straight handle." . [] oboInOwl:hasDbXref "PMID:18182077", "PMID:7577068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033103 ; owl:annotatedTarget "Increased concentration of chitinase 3-like 1 (CHI3L1) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:31235509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033104 ; owl:annotatedTarget "Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response." . [] oboInOwl:hasDbXref "PMID:24874532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033105 ; owl:annotatedTarget "An abnormal parenchymal band connecting the medial margins of the left and right hypothalami across the third ventricle." . [] oboInOwl:hasDbXref "PMID:19008457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033106 ; owl:annotatedTarget "An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "5-Ureidohydantoin" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46842 ; owl:annotatedTarget "Gmelin:323778" . [] oboInOwl:hasDbXref "PMID:30561103" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033110 ; owl:annotatedTarget "An abnormally increased level of alpa-aminobutyric acid in the blood circulation. Alpha-aminobutyric acid alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2." . [] oboInOwl:hasDbXref "PMID:29844061" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033111 ; owl:annotatedTarget "Concentration of 3-hydroxyisovaleric acid in the urine above the normal range." . [] oboInOwl:hasDbXref , "PMID:12006394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033112 ; owl:annotatedTarget "An increased concentration in blood of apolipoprotein C-III, a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033112 ; owl:annotatedTarget "Elevated APOC3 level" . [] oboInOwl:hasDbXref "PMID:15886379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033113 ; owl:annotatedTarget "In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse." . [] oboInOwl:hasDbXref "PMID:15886379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033114 ; owl:annotatedTarget "A type of gallop rhytm in which both the third and the fourth sounds are present." . [] oboInOwl:hasDbXref "PMID:30442110" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033115 ; owl:annotatedTarget "Abnormally increased concentration of tenascin-C in the blood circulation." . [] oboInOwl:hasDbXref "PMID:16679353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033116 ; owl:annotatedTarget "Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46842 ; owl:annotatedTarget "carboxy-N-methylmethanaminium" . [] oboInOwl:hasDbXref "PDBeChem" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "CARBOXY GROUP" . [] oboInOwl:hasDbXref "PMID:16679353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033117 ; owl:annotatedTarget "Inflammation of the lining of the upper small intestine (duodenum)." . [] oboInOwl:hasDbXref "PMID:18619825" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033119 ; owl:annotatedTarget "Elevation of right ventricular systolic pressure (RVSP) above normal limits. In adults, RVSP is normally 20-30 mmHg." . [] oboInOwl:hasDbXref "PMID:26091664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033120 ; owl:annotatedTarget "A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet" . [] oboInOwl:hasDbXref "PMID:16936230", "PMID:28613724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033121 ; owl:annotatedTarget "A cough with a characteristic sound that has been compared to a seal's bark." . [] oboInOwl:hasDbXref "PMID:12574077", "PMID:15705633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033123 ; owl:annotatedTarget "Abnormally increased level of osteopontin in the blood circulation" . [] oboInOwl:hasDbXref "PMID:32367058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033124 ; owl:annotatedTarget "An increased level of sorbitol in the blood circulation." . [] oboInOwl:hasDbXref "NCIT:C3209", "PMID:29314206" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033125 ; owl:annotatedTarget "An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement." . [] oboInOwl:hasDbXref "PMID:28470091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033126 ; owl:annotatedTarget "Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red coloured skin." . [] oboInOwl:hasDbXref "PMID:24235286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033130 ; owl:annotatedTarget "Anomalous echogenicity of the kidney on ultrasound examination." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "carboxy" . [] oboInOwl:hasDbXref "PMID:24235286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033131 ; owl:annotatedTarget "Increased echogenecity of the medullary region of the kidney." . [] oboInOwl:hasDbXref "PMID:24235286" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033132 ; owl:annotatedTarget "Increased echogenecity of the kidney cortex." . [] oboInOwl:hasDbXref "PMID:28203370" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033134 ; owl:annotatedTarget "Fibrous bands (i.e., bands of scar-like tissue) that span two or more intra-abdominal organs and/or the inner abdominal wall (i.e. peritoneal membrane)." . [] oboInOwl:hasDbXref "PMID:30666665" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033135 ; owl:annotatedTarget "Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia. Liver infarctions appear as hypoechoic nonvascular regions on conventional and Doppler sonography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033137 ; owl:annotatedTarget "A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli." . [] oboInOwl:hasDbXref "PMID:28127133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033138 ; owl:annotatedTarget "A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart." . [] oboInOwl:hasDbXref "PMID:25970099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033140 ; owl:annotatedTarget "The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna." . [] oboInOwl:hasDbXref "PMID:32706371" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033141 ; owl:annotatedTarget "Unusually severe clinical course of SARS-CoV-2 infection, manifested clinically by features such as dyspnea and hypoxia with diffuse bilateral ground-glass opacities of the lungs on computed tomographic scan with progressive respiratory insufficiency necessitating oxygen supplementation or mechanical ventilation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "-C(O)OH" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "-CO2H" . [] oboInOwl:hasDbXref "PMID:26420973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033143 ; owl:annotatedTarget "Inflammation of the lining of the middle section of the small intestine." . [] oboInOwl:hasDbXref "PMID:32119309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033144 ; owl:annotatedTarget "Any deviation of the concentration of ceruloplasmin in the blood from the normal range." . [] oboInOwl:hasDbXref "PMID:32119309" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033145 ; owl:annotatedTarget "Elevated concentration of ceruloplasmin in the blood circulation." . [] oboInOwl:hasDbXref "PMID:29909962" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033146 ; owl:annotatedTarget "Increased concentration of methylsuccinic acid in the blood circulation." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "-COOH" . [] oboInOwl:hasDbXref "PMID:32386558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033149 ; owl:annotatedTarget "Increased diameter (caliber) of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46883 ; owl:annotatedTarget "carboxyl group" . [] oboInOwl:hasDbXref "PMID:12661898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033154 ; owl:annotatedTarget "An increased concentration of lysyl-pyridinoline (deoxypyridinoline) cross-links in the blood circulation." . [] oboInOwl:hasDbXref "PMID:10508118", "PMID:28919799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033155 ; owl:annotatedTarget "Abnormally increased concentration of L-alloisoleucine in the blood circulation." . [] oboInOwl:hasDbXref "PMID:28919799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033156 ; owl:annotatedTarget "Abnormally increased level of L-alloisoleucine in the urine." . [] oboInOwl:hasDbXref "PMID:6780020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033157 ; owl:annotatedTarget "Abnormal increase of the concentration of 3-methylhistidine in the blood circulation." . [] oboInOwl:hasDbXref "PMID:10722772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033158 ; owl:annotatedTarget "An abnormal reduction in the number of beats per unit time of the respiratory cilia." . [] oboInOwl:hasDbXref "PMID:402573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033159 ; owl:annotatedTarget "Decreased level of inosine in urine. Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond." . [] oboInOwl:hasDbXref "PMID:20572300" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033163 ; owl:annotatedTarget "An increased number and/or abnormal type of bacteria in the small bowel. Small intestinal bacterial overgrowth has been defined as the presence of greater than one hundred thousand bacteria (i.e. colony-forming units, CFU) per mL of proximal jejunal aspiration. The normal value is ten thousand or few CFU/ml." . [] oboInOwl:hasDbXref "PMID:21880133", "PMID:29254324", "PMID:9191008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033164 ; owl:annotatedTarget "Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation." . [] oboInOwl:hasDbXref "PMID:30020729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033165 ; owl:annotatedTarget "Inflammation of the intestine leading to bacterial invasion causing cellular damage and death which causes necrosis of the colon and intestine." . [] oboInOwl:hasDbXref "PMID:30422556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033166 ; owl:annotatedTarget "An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis)." . [] oboInOwl:hasDbXref "PMID:32490121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033167 ; owl:annotatedTarget "A neutrophilic interstitial, perivascular and/or perieccrine infiltrate with leukocytoclasia. Notably, leukocytoclastic vasculitis is not present." . [] oboInOwl:hasDbXref , "PMID:27499643" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033168 ; owl:annotatedTarget "Abnormally reduced activity of mevalonate kinase, which is a key enzyme in the mevalonate biosynthetic pathway that leads to the synthesis of both cholesterol and nonsterol isoprenoids." . [] oboInOwl:hasDbXref "PMID:28194273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033169 ; owl:annotatedTarget "Abnormally reduced volume of air in the lungs upon the maximum effort of inspiration." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033169 ; owl:annotatedTarget "Reduced TLC" . [] oboInOwl:hasDbXref "PMID:7492193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033170 ; owl:annotatedTarget "Any deviation from the normal range of a skinfold thickness, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers." . [] oboInOwl:hasDbXref "PMID:27669294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033171 ; owl:annotatedTarget "Any deviation from the normal range of the thickness of the tricpes skinfold, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers." . [] oboInOwl:hasDbXref "PMID:27669294" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033172 ; owl:annotatedTarget "Increased thickness of the triceps skinfold, which is measured halfway down the back of the upper arm is increased." . [] oboInOwl:hasDbXref , "PMID:26110014", "PMID:28771412" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033173 ; owl:annotatedTarget "Return of lavage fluid with a milky apperance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033174 ; owl:annotatedTarget "Return of lavage fluid characteristically has a bloody apperance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding." . [] oboInOwl:hasDbXref "PMID:8789605" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033175 ; owl:annotatedTarget "Concentration of L-pyroglutamic acid in the blood is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:15831231" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033178 ; owl:annotatedTarget "An increased concentration of interleukin-8 in the circulation." . [] oboInOwl:hasDbXref , "PMID:31550101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033180 ; owl:annotatedTarget "The appendix testis or hydatid of Morgagni, is a vestigial remnant of the Müllerian duct located on the superior pole of the testicle between the testis and epididymis. Although this appendage has no vital function, it is present in 50% of males. Torsion of twisting of this vestigial remnant can be incredibly painful, but usually requires no medical intervention." . [] oboInOwl:hasDbXref "PMID:24007734", "PMID:26540492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033181 ; owl:annotatedTarget "Spinal epidural abscess (SEA) is caused by a suppurative infection in the epidural space. The mass effect of the abscess can compress and reduce blood flow to the spinal cord, conus medullaris, or cauda equina." . [] oboInOwl:hasDbXref "PMID:26995190" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033182 ; owl:annotatedTarget "An increase in concentration of cathepsin D in the blood circulation." . [] oboInOwl:hasDbXref "PMID:19500772" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033183 ; owl:annotatedTarget "A developmental defect of pulmonary lobation characterized by the presence of only two lobes of the right lung." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "Glyoxyldiureide" . [] oboInOwl:hasDbXref "PMID:19425169" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033185 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by infection by the Epstein-Barr virus." . [] oboInOwl:hasDbXref "PMID:19500772", "PMID:25052575", "PMID:27071622" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033186 ; owl:annotatedTarget "The term is commonly used to describe a putative abnormal location of pulmonary vein branches adjacent to pulmonary arteries within the same adventitial sheath. However, evidence has been provided that the vessels in question are not pulmonary veins, however represent dilated bronchial veins." . [] oboInOwl:hasDbXref "PMID:9196362" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033187 ; owl:annotatedTarget "Elevated levels of proline-containing dipeptides in urine." . [] oboInOwl:hasDbXref "PMID:9212761" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033188 ; owl:annotatedTarget "A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum." . [] oboInOwl:hasDbXref "PMID:29574060", "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033189 ; owl:annotatedTarget "Tooth root length more than 2 SD above mean, or subjectively apparently increased tooth root length." . [] oboInOwl:hasDbXref "PMID:18410979" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033190 ; owl:annotatedTarget "A large nonpalpable spot of the skin over 1 cm in dimension with increased pigmentation and increased hair growth." . [] oboInOwl:hasDbXref "PMID:25519493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033191 ; owl:annotatedTarget "An increased concentration of selenium in the blood circulation." . [] oboInOwl:hasDbXref "PMID:25519493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033192 ; owl:annotatedTarget "An abnormally reduced concentration of selenium in the blood circulation." . [] oboInOwl:hasDbXref "PMID:31603713", "PMID:31885839" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033193 ; owl:annotatedTarget "Swelling of the hepatocyte, rounding of its contour, and alteration of the cytoplasm, which takes on a reticulated, rarified, or flocculant quality. The cytoplasm of the ballooned hepatocytes often contains clumps of eosinophilic ropey material known as Mallory-Denk bodies (MDBs) or Mallory hyaline, which is composed of hyperphosphorylated misfolded intermediate filaments, ubiquitin, and ubiquitin-binding protein P62." . [] oboInOwl:hasDbXref "PMID:16939061", "PMID:19142989" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033196 ; owl:annotatedTarget "Infiltration of portal fields by inflammatory cells." . [] oboInOwl:hasDbXref "PMID:31583739" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033197 ; owl:annotatedTarget "Infiltration of inflammatory cells in lobules of the liver. A focus of lobular inflammation can be defined as two or more inflammatory cells (neutrophils, lymphocytes and other mononuclear cells, eosinophils and microgranulomas) within the lobule present within the sinusoids or surrounding injured hepatocytes (ballooned or apoptotic hepatocytes)." . [] oboInOwl:hasDbXref "PMID:18424693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033199 ; owl:annotatedTarget "An elevation of the concentration of interleukin 10 in the blood circulation." . [] oboInOwl:hasDbXref "PMID:32119424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033202 ; owl:annotatedTarget "Reduced intensity of the brachioradialis tendon reflex." . [] oboInOwl:hasDbXref "PMID:32119424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033203 ; owl:annotatedTarget "Increased intensity of the brachioradialis reflex." . [] oboInOwl:hasDbXref "PMID:30285397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033204 ; owl:annotatedTarget "Increased intensity of the triceps reflex." . [] oboInOwl:hasDbXref "PMID:30285397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033205 ; owl:annotatedTarget "Increased intensity of the biceps reflex." . [] oboInOwl:hasDbXref "PMID:30285397" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033206 ; owl:annotatedTarget "Increased intensity of the Achilles reflex." . [] oboInOwl:hasDbXref "PMID:26119182" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033207 ; owl:annotatedTarget "Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures." . [] oboInOwl:hasDbXref "PMID:21471096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033208 ; owl:annotatedTarget "A developmental defect of the alveolar airspace during cananicular lung development characterized by a decreased number of pulmonary capillaries located away from the alveolar epithelium, thickened alveolar septae, media hypertrophy of small pulmonary arteries and muscularization of distal arterioles, and in some cases lymphangiectasis." . [] oboInOwl:hasDbXref "PMID:31151956", "PMID:31189067" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033209 ; owl:annotatedTarget "Arrest of lung development in the pseudoglandular stage (weeks 8 to 16 of human gestation) resulting in small sized lungs, predominantly composed of bronchial and bronchiolar structures embedded in abundant loose mesenchyme that is poorly vascularized. Acinar structures are essentially absent, with no significant formation of saccules and no alveoli." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "Beilstein:3601755" . [] oboInOwl:hasDbXref "PMID:31189067" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033210 ; owl:annotatedTarget "Arrest of lung development in the cananicular stage (weeks 18 to 26 of human gestation) resulting in simplified acinar spaces, frequently with abundant intervening mesenchyme and no alveoli. In later arrest growth stages early saccular formations may be seen. May resemble the lobular maldevelopment often seen in alveolar capillary dysplasia/misaligment of the pulmonary veins without vein misalignment or marked hypertensive changes of the pulmonary arteries." . [] oboInOwl:hasDbXref "PMID:3542299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033211 ; owl:annotatedTarget "A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity." . [] oboInOwl:hasDbXref "PMID:3542299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033212 ; owl:annotatedTarget "Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added." . [] oboInOwl:hasDbXref "PMID:6466694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033213 ; owl:annotatedTarget "The concentration of suberic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:27427983" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033214 ; owl:annotatedTarget "Increased susceptibility to viral pneumonia, as manifested by recurrent episodes of viral pneumonias." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033216 ; owl:annotatedTarget "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus. Distribution can include vascular pole, perihilar, tip or neither tip, perihilar or vascular." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033217 ; owl:annotatedTarget "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the vascular pole/perihilum." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033218 ; owl:annotatedTarget "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the tip/tubular pole." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033219 ; owl:annotatedTarget "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at neither tip nor perihilar/vascular poles. Both the vascular and the tubular pole are present in the glomerular cross section." . [] oboInOwl:hasDbXref "PMID:15615815" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033220 ; owl:annotatedTarget "An increased concentration of 2-ethylhydracylic acid in the urine." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "Gmelin:49515" . [] oboInOwl:hasDbXref "PMID:29095912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033222 ; owl:annotatedTarget "An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells." . [] oboInOwl:hasDbXref , "PMID:28361304" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033223 ; owl:annotatedTarget "Any structural abnormality of the parietal epithelial cells that line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells at the urinary pole and with the podocytes at the vascular pole." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033224 ; owl:annotatedTarget "Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033225 ; owl:annotatedTarget "An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present" . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033226 ; owl:annotatedTarget "An insudative accumulation of amorphous, eosinophilic, periodic acid-Schiff (PAS)-positive, silver-negative material protruding from Bowman's capsule into the urinary space. Although not always evident by light microscopy, this material is located between Bowman's capsule and the parietal epithelial cells, in some cases associated with newly formed matrix material." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033227 ; owl:annotatedTarget "An area of basement membrane continuity between the glomerular tuft and Bowman's capsule, without intervening crescent and not adjacent to an area of segmental sclerosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033231 ; owl:annotatedTarget "Abnormal number of its constituent cells of the mesangium of the glomerulus of the kidney." . [] oboInOwl:hasDbXref , "PMID:19470685" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033232 ; owl:annotatedTarget "Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033233 ; owl:annotatedTarget "Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane." . [] oboInOwl:hasDbXref "PMID:21128132" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033236 ; owl:annotatedTarget "A failure to sustain attention that requires self-motivation to optimize performance." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "carboxyformate" . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033237 ; owl:annotatedTarget "Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033238 ; owl:annotatedTarget "Cytoplasmic projections into the urinary space from the luminal side of the podocyte." . [] oboInOwl:hasDbXref , "PMID:12934788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033240 ; owl:annotatedTarget "An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation." . [] oboInOwl:hasDbXref "PMID:7463297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033241 ; owl:annotatedTarget "An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold." . [] oboInOwl:hasDbXref , "PMID:29970781", "PMID:3484566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033242 ; owl:annotatedTarget "A horseshoe lung is an uncommon congenital abnormality caused by the partial fusion of the bases of both lungs behind the pericardial sac." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033243 ; owl:annotatedTarget "Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components." . [] oboInOwl:hasDbXref "PMID:29957271" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033244 ; owl:annotatedTarget "Accumulation of immature interstitial cells containing abundant cytoplasmic glycogen defined by periodic acid-Schiff (PAS) positive cells." . [] oboInOwl:hasDbXref , "PMID:10445627", "PMID:27792742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033245 ; owl:annotatedTarget "Any structural abnormality of alveolar type 2 (ATII) cells." . [] oboInOwl:hasDbXref , "PMID:17554398", "PMID:2166657" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033246 ; owl:annotatedTarget "Increase in size of type II pneumocytes, characterized by qualitative morphologic alterations, including cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin." . [] oboInOwl:hasDbXref , "PMID:31538016" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033248 ; owl:annotatedTarget "Fibrosing nodules, consisting of either unilateral or bilateral central whorled deposits of lamellar collagen hyalin." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "Hox" . [] oboInOwl:hasDbXref , "PMID:25029335" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033250 ; owl:annotatedTarget "An increased number of turns of the blood vessels of the nailfold with a charactereistic winded or twisted appearance of the blood vessels." . [] oboInOwl:hasDbXref "PMID:12934788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033251 ; owl:annotatedTarget "Increase in the amount of air remaining in a person's lungs after full exhalation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033251 ; owl:annotatedTarget "Elevated RV" . [] oboInOwl:hasDbXref "PMID:23301728" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033252 ; owl:annotatedTarget "Exaggerated skin markings (dermatoglyphics) on the palms of the hand." . [] oboInOwl:hasDbXref "PMID:25109493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033254 ; owl:annotatedTarget "Narrowing of the anorectum associated with inflammation or scar tissue." . [] oboInOwl:hasDbXref , "PMID:31118601" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033255 ; owl:annotatedTarget "A congenital malformation characterized by an overdistended segment of lung, affecting an party of a lobe or the entire one. It results in progressive overinflation of one or more lobes." . [] oboInOwl:hasDbXref "PMID:16189424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033256 ; owl:annotatedTarget "Inflammation of the entire colon." . [] oboInOwl:hasDbXref , , "PMID:22191982" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033258 ; owl:annotatedTarget "Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033258 ; owl:annotatedTarget "SUDEP" . [] oboInOwl:hasDbXref "PMID:2827606", "PMID:28276060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033259 ; owl:annotatedTarget "A seizure with clinical manifestation but without motor signs (other than possible behavior arrest) as its initial clinical manifestation. The electrographic onset may be generalized, focal, or unknown." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "hydrogen ethanedioate" . [] oboInOwl:hasDbXref "PMID:26500860", "PMID:31753828" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033260 ; owl:annotatedTarget "Livedo racemosa describes a reddish-blue mottling of the skin in an irregular, reticular pattern. It differs from the more common livedo reticularis by its shape. Livedo racemosa consists of broken circular segments resulting in a seemingly larger pattern, as opposed to the fine, regular, complete network of livedo reticularis. Livedo racemosa results from permanent impairment of peripheral blood flow and, unlike livedo reticularis, it persists on warming." . [] oboInOwl:hasDbXref "PMID:25537277" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033261 ; owl:annotatedTarget "Increase in diameter of a segment of the renal artery that can be defined as a focal, isolated dilatation of all three layers of the arterial wall over 1.5 times the diameter of the disease-free proximal adjacent arterial segment." . [] oboInOwl:hasDbXref "PMID:26808044" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033262 ; owl:annotatedTarget "A fracture through the distal humeral physis that separates the entire distal humeral epiphysis from the metaphysis." . [] oboInOwl:hasDbXref "PMID:11809908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033263 ; owl:annotatedTarget "Lack of platelet dense granules, a type of platelet organelles." . [] oboInOwl:hasDbXref "PMID:16551969" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033264 ; owl:annotatedTarget "Increased size of platelet dense granules." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033265 ; owl:annotatedTarget "Lamellated intracytoplasmic lipid inclusions within podocytes." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033266 ; owl:annotatedTarget "Visceral epithelial cell hyperplasia with resulting cellular crowding of the the urinary space. In contrast with true crescents, these proliferations lack inflammatory cells and fibrin. The cells are typically plump (not spindle-shaped) and often vacuolated, and Bowman's capsule is usually intact." . [] oboInOwl:hasDbXref "PMID:24875196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033267 ; owl:annotatedTarget "Abnormal structural characteristics of the interior space of the capillary of the renal glomerulus." . [] oboInOwl:hasDbXref , "PMID:27102348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033268 ; owl:annotatedTarget "Wrinkling and folding of the capillaries without epithelial cell (podocyte) hyperplasia (formerly called ischemic type of collapse) involving o 80% of the glomerular tuft. The wrinkling is generally made by small regular folds of the glomerular basement membrane." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033269 ; owl:annotatedTarget "Collapse is generally accompanied by other descriptors such as hypertrophy and hyperplasia of overlying glomerular epithelial cells, halo, protein droplets in podocytes and glomerular parietal epithelial cells (PECs)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46904 ; owl:annotatedTarget "hydrogen oxalate" . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033270 ; owl:annotatedTarget "Global distention of glomerular capillaries with intraluminal intact red blood cells." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033271 ; owl:annotatedTarget "Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis." . [] oboInOwl:hasDbXref , "PMID:29629372" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033272 ; owl:annotatedTarget "An abnormal structure of the glomerular endothelial cells, which are highly specialized cells with fenestrae and a charged luminal glycocalyx layer that contribute to the filtration barrier." . [] oboInOwl:hasDbXref , "PMID:19129259" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033273 ; owl:annotatedTarget "Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm." . [] oboInOwl:hasDbXref , "PMID:14511965" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033274 ; owl:annotatedTarget "Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen." . [] oboInOwl:hasDbXref , "PMID:23957425" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033275 ; owl:annotatedTarget "Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon." . [] oboInOwl:hasDbXref , "PMID:29459092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033277 ; owl:annotatedTarget "Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis." . [] oboInOwl:hasDbXref "PMID:21625644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033278 ; owl:annotatedTarget "Reduced amount of programmed cell death in peripheral blood lymphocytes following exposure to CD95 (APO-1/Fas), which is a member of the death receptor family, a subfamily of the TNF-R superfamily. Crosslinking of CD95 with its natural ligand CD95L (CD178) or with agonistic antibodies such as anti-APO-1 induces apoptosis in sensitive cells." . [] oboInOwl:hasDbXref "PMID:27247538" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033279 ; owl:annotatedTarget "An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin." . [] oboInOwl:hasDbXref "PMID:4023240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033280 ; owl:annotatedTarget "Enlargement of lymph nodes surrounding the trachea." . [] oboInOwl:hasDbXref "PMID:28633658" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033281 ; owl:annotatedTarget "The presence of nucleated red blood cells in the peripheral blood circulation." . [] oboInOwl:hasDbXref "PMID:29435440" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033282 ; owl:annotatedTarget "Any abnormal sttructure of the glomerular basement membrane." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033283 ; owl:annotatedTarget "Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033284 ; owl:annotatedTarget "Prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033287 ; owl:annotatedTarget "Lucent zones within the glomerular basement membranes. May reflect remote/resolved deposits." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0033288 ; owl:annotatedTarget "Delicate, silver positive projections that extend at right angles from the glomerular basement membrane (GBM) out into the urinary space, creating an irregular GBM profile." . [] oboInOwl:hasDbXref , "PMID:21827618", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033290 ; owl:annotatedTarget "Expansion of the space between the glomerular endothelium and lamina densa by electron-lucent material." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033291 ; owl:annotatedTarget "Apoptotic, pyknotic, and fragmented nuclei within the glomerulus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033292 ; owl:annotatedTarget "An aggregate of coagulated blood containing fibrin, with or without entrapped cellular elements, within a glomerular capillary lumen." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033293 ; owl:annotatedTarget "Intracapillary amorphous, eosinophilic material consisting of immune deposits." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033294 ; owl:annotatedTarget "Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033295 ; owl:annotatedTarget "Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033296 ; owl:annotatedTarget "Visceral epithelial cells with 2 nuclei. Can be observed on light or ultrastructral microscopy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033297 ; owl:annotatedTarget "Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy." . [] oboInOwl:hasDbXref "PMID:27814381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033298 ; owl:annotatedTarget "A deviation from the normal concentration in blood of factor H-related protein 1 (FHR-1)" . [] oboInOwl:hasDbXref "PMID:25468829" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033305 ; owl:annotatedTarget "Any deviation from the normal concentration of fetuin A in the blood circulation." . [] oboInOwl:hasDbXref "PMID:17872641" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033309 ; owl:annotatedTarget "A type of intussusception of the small intestine in which one part of the ileum invaginates (telescopes) into another part of the ileum." . [] oboInOwl:hasDbXref "PMID:22677080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033310 ; owl:annotatedTarget "Osmotic diarrhea results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption." . [] oboInOwl:hasDbXref "PMID:15902826" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033311 ; owl:annotatedTarget "A tear in the intimal layer of the abdominal aorta causing a separation between the intima and the medial layers." . [] oboInOwl:hasDbXref "PMID:32119361" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033312 ; owl:annotatedTarget "Structural anomaly located in Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron." . [] oboInOwl:hasDbXref "HMDB" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15676 ; owl:annotatedTarget "N-(2,5-Dioxo-4-imidazolidinyl)urea" . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033313 ; owl:annotatedTarget "Acellular collagenous matrix within Bowman's space, not associated with extracapillary hypercellularity or necrosis, associated with sclerosis or deflation of the tuft." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033314 ; owl:annotatedTarget "Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033315 ; owl:annotatedTarget "Round to ovoid, Periodic acid-Schiff (PAS)-positive, fuchsinophilic cytoplasmic inclusions within visceral epithelial cells." . [] oboInOwl:hasDbXref , "PMID:32132388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033316 ; owl:annotatedTarget "Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin." . [] oboInOwl:hasDbXref "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033317 ; owl:annotatedTarget "A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033318 ; owl:annotatedTarget "A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033319 ; owl:annotatedTarget "A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033321 ; owl:annotatedTarget "Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033322 ; owl:annotatedTarget "Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033323 ; owl:annotatedTarget "Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM." . [] oboInOwl:hasDbXref "PMID:24770509", "PMID:27041288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033327 ; owl:annotatedTarget "Psoriatic nail abnormality characterized by the presence of neutrophils in the nail bed epithelium, hyperkeratosis with parakeratosis, presence of exudates on the corneal epithelium, focal hypogranulosis and psoriasiform hyperplasia of the nail bed." . [] oboInOwl:hasDbXref , "PMID:11079017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033328 ; owl:annotatedTarget "Increase in the number of type II pneumocytes." . [] oboInOwl:hasDbXref "PMID:15246484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033329 ; owl:annotatedTarget "Anomaly of the physiological response to maintain the body's posture when movement and position is altered." . [] oboInOwl:hasDbXref "PMID:13502822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033330 ; owl:annotatedTarget "Abnormal neck-righting response, which is said to be a physiological response when a child is placed flat on his or her back and the head is turned 90 degrees to the right or the left. With a normal neck-righting response, there follows a reflected torsion of the vertebral column in the same direction as the induced rotation of the neck. That is, the whole body follows the direction in which the head was turned. The response is present from birth to the age of five years." . [] oboInOwl:hasDbXref "PMID:20034426", "PMID:30137854" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033331 ; owl:annotatedTarget "Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing." . [] oboInOwl:hasDbXref "PMID:30165816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033332 ; owl:annotatedTarget "An increased concentration of serum amyloid A in the blood circulation." . [] oboInOwl:hasDbXref "PMID:12453260" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033333 ; owl:annotatedTarget "Limitation of motion of the jaw due to structural changes in a muscle such as the massseter responsible for jaw movement." . [] oboInOwl:hasDbXref "PMID:32680920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033334 ; owl:annotatedTarget "An anomaly in the development of the embryo, that is, of the early developmental stage of development that follows the fertilization of an egg by sperm." . [] oboInOwl:hasDbXref "PMID:32502391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033336 ; owl:annotatedTarget "Failure of a fertilized oocyte to undergo the first round of cell division." . [] oboInOwl:hasDbXref , "PMID:24260168", "PMID:24415568", "PMID:25889963", "PMID:31312230" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033342 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against aquaporin-4." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46912 ; owl:annotatedTarget "2,5-diammoniopentanoate" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033342 ; owl:annotatedTarget "Anti-AQP4 antibody positivity" . [] oboInOwl:hasDbXref "PMID:31869107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033343 ; owl:annotatedTarget "Passage of an increased number of stools containing mucus, a thick fluid substance secreted by mucous membranes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033343 ; owl:annotatedTarget "Mucous diarrhoea" . [] oboInOwl:hasDbXref , "PMID:27618319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033344 ; owl:annotatedTarget "A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura." . [] oboInOwl:hasDbXref "PMID:29871784", "PMID:32305858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033349 ; owl:annotatedTarget "A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient." . [] oboInOwl:hasDbXref , "PMID:19671143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033350 ; owl:annotatedTarget "An increase in the amount of air a person can forcefully expel in one second, compared to some standard or previous measure of same subject." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033350 ; owl:annotatedTarget "Elevated FEV1" . [] oboInOwl:hasDbXref "PMID:30725953" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033351 ; owl:annotatedTarget "Candida infections of the esophagus are considered opportunistic infections and are seen most commonly in immunosuppressed patients, the most common symptoms being dysphagia, odynophagia, and retrosternal pain." . [] oboInOwl:hasDbXref "PMID:27295157" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033352 ; owl:annotatedTarget "Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output." . [] oboInOwl:hasDbXref "PMID:12661898", "PMID:9127470" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033355 ; owl:annotatedTarget "An increased level of deoxypyridinoline in the urine. Deoxypyridinoline is a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, has been described as a marker of bone turnover." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46912 ; owl:annotatedTarget "ornithinium" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033355 ; owl:annotatedTarget "Elevated urinary DPD" . [] oboInOwl:hasDbXref "PMID:23356593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033360 ; owl:annotatedTarget "A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible." . [] oboInOwl:hasDbXref "PMID:11314863", "PMID:25441476", "PMID:26657735" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033361 ; owl:annotatedTarget "An open sore of the nasal mucosa." . [] oboInOwl:hasDbXref , "PMID:24224590" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033363 ; owl:annotatedTarget """Hyaline membranes are homogeneous eosinophilic material composed of cellular debris, plasma proteins, and surfactant plastered against alveolar ducts and alveolar walls. The hyaline membranes are deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.""" . [] oboInOwl:hasDbXref , "PMID:20028911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033364 ; owl:annotatedTarget "A specific form of lung inflammation that results from accumulation of lipids in the alveoli. Lipoid pneumonia can be either exogenous or endogenous in cause based on the source of the lipid." . [] oboInOwl:hasDbXref , "PMID:20028911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033365 ; owl:annotatedTarget "A type of lipoid pneumonia in which the source of the lipids is the body itself. When an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace." . [] oboInOwl:hasDbXref , "PMID:20028911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033366 ; owl:annotatedTarget "A type of lipoid pneumonia in which the source of the lipids is external to the body." . [] oboInOwl:hasDbXref , "PMID:27669319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033367 ; owl:annotatedTarget "Low level of blood oxygen induced by changing from a recumbent to an upright position." . [] oboInOwl:hasDbXref , "PMID:27669319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033368 ; owl:annotatedTarget "A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position." . [] oboInOwl:hasDbXref , "PMID:32522799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033369 ; owl:annotatedTarget "A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46912 ; owl:annotatedTarget "ornithinium(1+)" . [] oboInOwl:hasDbXref , "PMID:31466963", "PMID:3359830" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033370 ; owl:annotatedTarget "Telangiectasias (small dilated blood vessels located near the surface of the skin or mucous membranes) located in the trachoebronchial system." . [] oboInOwl:hasDbXref , "PMID:26744680" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033371 ; owl:annotatedTarget "Granulomatous inflammation that surrounds the bronchi and bronchioles, replacing bronchial walls and mucosa. In bronchocentric granulomatosis, the lumen of the airway contains necrotic debris, and palisaded histiocytes surround the lumen." . [] oboInOwl:hasDbXref , "PMID:11334115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033372 ; owl:annotatedTarget "Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O." . [] oboInOwl:hasDbXref , "PMID:11334115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033373 ; owl:annotatedTarget "Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index)." . [] oboInOwl:hasDbXref , "PMID:11334115" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033374 ; owl:annotatedTarget "Decreased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index)." . [] oboInOwl:hasDbXref , "PMID:29892540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033375 ; owl:annotatedTarget "Anthracosis is the deposition of black carbon pigment. It is commonly seen in perihilar lymph nodes as well as within lung parenchyma. There can be prominent storiforming (i.e., spiral patterning) of histiocytes, to such an extent as to mimic a neoplastic lesion histologically. Anthracosis is a common finding in smokers and polluted city dwellers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033376 ; owl:annotatedTarget "Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology." . [] oboInOwl:hasDbXref , "PMID:20884725", "PMID:26474448", "PMID:30521210", "PMID:32558323", "PMID:33306420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033377 ; owl:annotatedTarget "Presence of increased numbers of bombesin-immuno-positive neuroendocrine cells (NECs) within distal airways. There are no formal criteria for an increase (which is also dependend on the sensitivity of the staining method), findings of neuroendocrine cells in at least 70% of bronchioles by lung biopsy and at least 10% NECs in an individual airway are consistent with the diagnosis of Neuroendocrine cell hyperplasia of infancy in the appropriate clinical setting. Increases are also seen in other clicnial settings. Neuroendocrine neoplasms of the lung encompass NE tumors (NETs), which split into typical and atypical carcinoids, and NE carcinomas (NECs)." . [] oboInOwl:hasDbXref , "PMID:10623675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033378 ; owl:annotatedTarget "Presence of increased numbers of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts." . [] oboInOwl:hasDbXref "PMID:18847480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033379 ; owl:annotatedTarget "The presence of a left and a right superior vena cava." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46912 ; owl:annotatedTarget "ornithine monocation" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033379 ; owl:annotatedTarget "Bilateral SVC" . [] oboInOwl:hasDbXref "PMID:33108101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033380 ; owl:annotatedTarget "Inflammation of the cartilage of the nose." . [] oboInOwl:hasDbXref "PMID:15961865" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033383 ; owl:annotatedTarget "Reduced level of the compound muscle action potential (CMAP), which is recorded following electrical stimulation of a nerve from surface electrodes overlying a muscle supplied by that nerve." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033383 ; owl:annotatedTarget "Decreased CMAP amplitude" . [] oboInOwl:hasDbXref "PMID:26306627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033385 ; owl:annotatedTarget "An increased amount of pyridinoline in the urine." . [] oboInOwl:hasDbXref "PMID:26306627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033387 ; owl:annotatedTarget "An increased concentration of hydroxylysyl-pyridinoline (pyridinoline) in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:25590386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033388 ; owl:annotatedTarget "Any structural abnormality of a bronchial artery." . [] oboInOwl:hasDbXref , "PMID:10598843" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033389 ; owl:annotatedTarget "Abnormal arterial anastomosis (connection) between bronchial and pulmonary arteries." . [] oboInOwl:hasDbXref , "PMID:25590386", "PMID:32430593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033390 ; owl:annotatedTarget "Increased caliber of a bronchial artery, which can be defined as a bronchial artery diameter that exceeds 2 mm." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46913 ; owl:annotatedTarget "1-carboxybutane-1,4-diaminium" . [] oboInOwl:hasDbXref , "PMID:25590386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033391 ; owl:annotatedTarget "Increase in the volume of bronchial artery wall due to the enlargement of its component cells." . [] oboInOwl:hasDbXref "PMID:26472152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033393 ; owl:annotatedTarget "Irregular or changing caliber (diameter) along the tail of the sperm." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033393 ; owl:annotatedTarget "Sperm flagella with irregular calibre" . [] oboInOwl:hasDbXref , "PMID:16932997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033394 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase II." . [] oboInOwl:hasDbXref , "PMID:16932997" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033395 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against lactoferrin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033396 ; owl:annotatedTarget "Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033397 ; owl:annotatedTarget "The presence of eosinophilic Periodic Acid Schiff (PAS)-positive cell free, protein-derived material occupying Bowman's space." . [] oboInOwl:hasDbXref , "PMID:929215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033398 ; owl:annotatedTarget "Deposits of hyalinized collagen fibres in the parietal pleura (preferentially pleura adjacent to ribs, particularly the sixth through ninth ribs)." . [] oboInOwl:hasDbXref "PMID:14677667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033399 ; owl:annotatedTarget "Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks." . [] oboInOwl:hasDbXref "PMID:29083722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033400 ; owl:annotatedTarget "A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46913 ; owl:annotatedTarget "ornithinediium" . [] oboInOwl:hasDbXref "PMID:10720362", "PMID:26858079" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033401 ; owl:annotatedTarget "Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion." . [] oboInOwl:hasDbXref "PMID:33102026" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033403 ; owl:annotatedTarget "Restriction of arterial blood supply to a testis associated with insufficient oxygenation to support the metabolic requirements of the tissue. Clinical manifestations may include pain and swelling of the affected testis." . [] oboInOwl:hasDbXref "PMID:30306080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033404 ; owl:annotatedTarget "Restriction of arterial blood supply to the intestine associated with insufficient oxygenation to support the metabolic requirements of the tissue. Acute intestinal ischemia can involve the small or large intestine, and usually presents with sudden severe non-specific abdominal pain." . [] oboInOwl:hasDbXref "PMID:11344564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033407 ; owl:annotatedTarget "Elevated amount of acetoacetic acid in the urine." . [] oboInOwl:hasDbXref "PMID:25317315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033410 ; owl:annotatedTarget "An increased blood concentration of cartilage oligomeric matrix protein (COMP)." . [] oboInOwl:hasDbXref , "PMID:12917306", "PMID:28613742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033415 ; owl:annotatedTarget "The accumulation of pericardial fluid with subsequent compression of all cardiac chambers which prevents cardiac filling." . [] oboInOwl:hasDbXref "PMID:28914719" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033416 ; owl:annotatedTarget "Reduced ability to bring the leg toward the midline of the body." . [] oboInOwl:hasDbXref "PMID:27208342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033418 ; owl:annotatedTarget "Elevation of the 2-hydroxybutyric acid concentration in the blood above the normal range." . [] oboInOwl:hasDbXref , "PMID:8504682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033420 ; owl:annotatedTarget "Focal proliferation of pulmonary artery endothelial cells, leading to the formation of complex capillary-like channels." . [] oboInOwl:hasDbXref , "PMID:23606929", "PMID:28025704" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033421 ; owl:annotatedTarget "Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10%." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46913 ; owl:annotatedTarget "ornithinium(2+)" . [] oboInOwl:hasDbXref , "PMID:17008597", "PMID:23737168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033422 ; owl:annotatedTarget "Increased amount of collagen, proteoglycans, and other extracellular matrix proteins resulting in scarring and thickening in the adventia of the pulmonary arterial tree." . [] oboInOwl:hasDbXref "PMID:15939821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033423 ; owl:annotatedTarget "A form of pulmonary arterial hypertension in which there is a reduction of mean pulmonary artery pressure (mPAP) at leasy 10 mmHg to reach an absolute value of mPAP not more than 40 mmHg with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm." . [] oboInOwl:hasDbXref "PMID:15939821" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033424 ; owl:annotatedTarget "A form of pulmonary arterial hypertension with lack of adequate hemodynamic response to NO challenge (adequate response is defined as a reduction of mean pulmonary artery pressure (mPAP) of at least 10 mmHg to reach an absolute value of mPAP 40 mmHg or less with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm)." . [] oboInOwl:hasDbXref , "PMID:9172037" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033426 ; owl:annotatedTarget "Venous air embolism is a consequence of air being introduced into the venous circulation, and subsequently to the right heart, and pulmonary circulation. When small amounts of air reach pulmonary circulation they can be removed by gas diffusion across the arteriolar wall into the alveoli, amounts of gas exceeding 50 ml can cause pulmonary outflow tract obstruction with or without concomitant arterial embolisation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033427 ; owl:annotatedTarget "Focal accumulation of dilated pulmonary capillaries." . [] oboInOwl:hasDbXref "PMID:31194388" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033431 ; owl:annotatedTarget "A form of cytomegalovirus infection characterized by infection and inflammation of the colon." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033431 ; owl:annotatedTarget "CMV colitis" . [] oboInOwl:hasDbXref "PMID:28744345" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033433 ; owl:annotatedTarget "An erosion of the mucous membrane in the region connecting the ileum and cecum." . [] oboInOwl:hasDbXref "PMID:30725893" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033434 ; owl:annotatedTarget "A full-thickness defect of the nasal septum." . [] oboInOwl:hasDbXref "PMID:29262167" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033438 ; owl:annotatedTarget "An increased blood concentration of myoglobin." . [] oboInOwl:hasDbXref "JCBN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_46913 ; owl:annotatedTarget "ornithine dication" . [] oboInOwl:hasDbXref "PMID:15617193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033442 ; owl:annotatedTarget "Increased concentration of glutarylcarnitine in the blood circulation." . [] oboInOwl:hasDbXref "PMID:27806975", "PMID:27831914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033448 ; owl:annotatedTarget "Elevation of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children." . [] oboInOwl:hasDbXref "PMID:27806975", "PMID:27831914" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033449 ; owl:annotatedTarget "Reduction of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children." . [] oboInOwl:hasDbXref "PMID:11989633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033450 ; owl:annotatedTarget "Any deviation from normal concentration of albumin in the blood circulation." . [] oboInOwl:hasDbXref "PMID:11989633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033452 ; owl:annotatedTarget "A reduction from the normal concentration of prealbumin in the blood circulation." . [] oboInOwl:hasDbXref "PMID:25874832", "PMID:28044031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033454 ; owl:annotatedTarget "Feeding problem necessitating food and nutrient delivery via a tube." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033464 ; owl:annotatedTarget "Elevated circulating 3-OH-palmitoleylcarnitine concentration" . [] oboInOwl:hasDbXref "PMID:26055647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033466 ; owl:annotatedTarget "Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand." . [] oboInOwl:hasDbXref "PMID:32296967" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033475 ; owl:annotatedTarget "Decreased ability to move the arm away from the midline of the body." . [] oboInOwl:hasDbXref "PMID:11899137", "PMID:16338206" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033476 ; owl:annotatedTarget "The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution." . [] oboInOwl:hasDbXref "PMID:30725725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033477 ; owl:annotatedTarget "A deviation from the normal concentration of lipoprotein lipase in the blood circulation." . [] oboInOwl:hasDbXref "PMID:30725725" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033478 ; owl:annotatedTarget "Increased concentration of lipoprotein lipase in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:32393263", "PMID:33276871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033483 ; owl:annotatedTarget "Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033485 ; owl:annotatedTarget "A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033486 ; owl:annotatedTarget "Anomalous appearance or structure of the surface of the glomerular basement membrane." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033487 ; owl:annotatedTarget "Punctate electron-dense material typically in a band-like distribution along the lamina rara interna and within tubular basement membranes within the subendothelial aspect of the glomerular basement membrane." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033488 ; owl:annotatedTarget "Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033489 ; owl:annotatedTarget "Increased number of neutrophils internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033490 ; owl:annotatedTarget "Presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in the glomerulus often occupying the endocapillary space." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033491 ; owl:annotatedTarget "A generalized global (over 80%) increase of mesangial matrix that is present throughout the mesangial stalk (with or without associated mesangial hypercellularity)." . [] oboInOwl:hasDbXref , "PMID:27102348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033492 ; owl:annotatedTarget "Reorganization of podocyte cytoskeletal proteins at the glomerular basement membrane (GBM) aspect of the cell, with associated cytoplasmic electron density at the GBM aspect of the podocyte." . [] oboInOwl:hasDbXref "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033493 ; owl:annotatedTarget "Increased mesangial extracellular material with interspace width of over 2 mesangial cell nuclei, in one or more peripheral mesangial areas." . [] oboInOwl:hasDbXref "PMID:25852856", "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033494 ; owl:annotatedTarget "Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033495 ; owl:annotatedTarget "Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule." . [] oboInOwl:hasDbXref "PMID:27437509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033496 ; owl:annotatedTarget "Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration is present at the vascular pole, involving less than 50% of the tuft. It can be accompanied by other descriptors such as hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman's capsule." . [] oboInOwl:hasDbXref , "PMID:27437509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033497 ; owl:annotatedTarget "Segmental solidification of the glomerular tuft characterized by an adhesion at the tip of the glomerular tuft abutting the proximal tubular taek-off can be accompanied by increased extracellular matrix, causing glomerular capillary obliteration at the glomerular tip. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033498 ; owl:annotatedTarget "Segmental solidification of the glomerular tuft characterized by increased extracellular matrix, causing glomerular capillary obliteration at neirhter the tubular or vascular poles. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed." . [] oboInOwl:hasDbXref "PMID:33329990" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033499 ; owl:annotatedTarget "Electron-dense deposits in the lamina densa with a ribbon or a sausage structure." . [] oboInOwl:hasDbXref "PMID:31290619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033503 ; owl:annotatedTarget "An increased concentration of fumarate, an intermediate in the citric acid cycle, in the cebrebrospinal fluid." . [] oboInOwl:hasDbXref "PMID:31290619" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033504 ; owl:annotatedTarget "An increased concentration of fumarate, an intermediate in the citric acid cycle, in the blood circulation." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46915 ; owl:annotatedTarget "Beilstein:3536300" . [] oboInOwl:hasDbXref "PMID:22018204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033508 ; owl:annotatedTarget "Inflammation of the meninges related to infection by Epstein-Barr virus." . [] oboInOwl:hasDbXref "PMID:22018204" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033509 ; owl:annotatedTarget "Inflamation of the brain related to infection by Epstein-Barr virus." . [] oboInOwl:hasDbXref , "PMID:33085427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033510 ; owl:annotatedTarget "A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033512 ; owl:annotatedTarget "Addiction to a stimulant drug, defined as a drug that typically increases alertness, attention and energy while also elevating blood pressure, heart rate and breathing." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033513 ; owl:annotatedTarget "Addiction to cocaine." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033514 ; owl:annotatedTarget "Addiction to amphetamine or dextroamphetamine." . [] oboInOwl:hasDbXref , "PMID:27508068" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033515 ; owl:annotatedTarget "Addiction to opioids." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033516 ; owl:annotatedTarget "Addiction to a benzodiazepine." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033517 ; owl:annotatedTarget "Addiction to heroin." . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033518 ; owl:annotatedTarget "Addiction to methylphenidate." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46915 ; owl:annotatedTarget "Gmelin:81987" . [] oboInOwl:hasDbXref , "PMID:28790493" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033519 ; owl:annotatedTarget "Addiction to methamphetamine." . [] oboInOwl:hasDbXref , "PMID:11700487", "PMID:12130431" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033520 ; owl:annotatedTarget "Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation." . [] oboInOwl:hasDbXref , "PMID:12391797", "PMID:20465792" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033521 ; owl:annotatedTarget "A lack of humidification of the nasal mucosa." . [] oboInOwl:hasDbXref "PMID:30909834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033522 ; owl:annotatedTarget "A cerebral cavernous malformation (also known as cavernoma, cavernous angioma, cavernous hemangioma) is a collection of structurally abnormal slow-flow capillaries predominantly in the central nervous system. These are multiple mulberry-like distended caverns of dilated thin-walled capillaries without the normal intervening brain parenchymal architecture. Often, individual cavernomas are surrounded by hemosiderin representing remote oozing due to the abnormal capillaries." . [] oboInOwl:hasDbXref "PMID:29024992" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033523 ; owl:annotatedTarget "A structural anomaly of the part of the sperm flagellum that is distal to the sperm midpiece and mitochondrial sheath and which leads into the end piece." . [] oboInOwl:hasDbXref "PMID:31781811" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033524 ; owl:annotatedTarget "Abnormal structure of the sperm axonemal structure which consists of a ring of nine microtubular doublets and a central pair of microtubules, giving the classical 9+2 microtubular arrangement. The axoneme contains a central pair of microtubules (C1 and C2) that are connected by a bridge-like structure forming the central pair complex (CPC). Each of the nine outer doublets is composed of type A and B microtubules and connected by radial spokes to the CPC." . [] oboInOwl:hasDbXref "PMID:31278745" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033525 ; owl:annotatedTarget "Absense of the central pair of microtubules in the sperm axoneme, thereby forming a 9+0 pattern instead of the normal 9+2 pattern." . [] oboInOwl:hasDbXref "PMID:22506166", "PMID:26589087", "PMID:27465627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033526 ; owl:annotatedTarget "Reduced ability to move the foot up toward the shin." . [] oboInOwl:hasDbXref "PMID:10599740", "PMID:11155091" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033527 ; owl:annotatedTarget "A reduced amount of testosterone relative in androstenedione in the blood circulation following administration of hCG (Human Chorionic Gonadotropin)." . [] oboInOwl:hasDbXref "PMID:18771592", "PMID:29262215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033528 ; owl:annotatedTarget "A deviation from normal Cardiac output, which is defined as the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_46915 ; owl:annotatedTarget "Reaxys:3536300" . [] oboInOwl:hasDbXref , "PMID:30969727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033529 ; owl:annotatedTarget "Any deviation from the normal value of the cardiac index, defined as cardiac output divided by body surface area." . [] oboInOwl:hasDbXref , "PMID:30969727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033530 ; owl:annotatedTarget "An elevated cardiac index, defined as cardiac output divided by body surface area." . [] oboInOwl:hasDbXref , "PMID:30969727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033531 ; owl:annotatedTarget "A reduced cardiac index, defined as cardiac output divided by body surface area." . [] oboInOwl:hasDbXref , "PMID:18771592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033532 ; owl:annotatedTarget "A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat." . [] oboInOwl:hasDbXref , "PMID:18771592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033533 ; owl:annotatedTarget "An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat." . [] oboInOwl:hasDbXref , "PMID:16698841" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033534 ; owl:annotatedTarget "An increased concentration of brain natriuretic peptide in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033534 ; owl:annotatedTarget "Elevated circulating BNP concentration" . [] oboInOwl:hasDbXref "PMID:31217188" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033535 ; owl:annotatedTarget "Decreased number of platelet dense granules, a type of platelet organelle." . [] oboInOwl:hasDbXref "PMID:31217188" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033536 ; owl:annotatedTarget "A reduced number of platelet alpha granules." . [] oboInOwl:hasDbXref , "PMID:26274445" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033537 ; owl:annotatedTarget "Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46915 ; owl:annotatedTarget "(methylamino)acetate" . [] oboInOwl:hasDbXref , "PMID:16461818", "PMID:22699285", "PMID:31157994" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033538 ; owl:annotatedTarget "Pathological deposition of calcium salts in the aortic annulus, a fibrous ring-like structure found at the insertion point of the basal attachments of the aortic valve leaflets within the left ventricular outflow tract." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_46915 ; owl:annotatedTarget "sarcosinate" . [] oboInOwl:hasDbXref , "PMID:16376803" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033539 ; owl:annotatedTarget "A reticular pattern of linear or lineonodular densities in apical portions of both the right and left lungs seen initially on high-resolution computed tomography and in case of progression also on standard chest x-ray." . [] oboInOwl:hasDbXref , "PMID:16264058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033540 ; owl:annotatedTarget "Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL." . [] oboInOwl:hasDbXref , "PMID:16264058" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033541 ; owl:annotatedTarget "Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL." . [] oboInOwl:hasDbXref , "PMID:10555672", "PMID:928676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033542 ; owl:annotatedTarget "Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033545 ; owl:annotatedTarget "Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033546 ; owl:annotatedTarget "Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins." . [] oboInOwl:hasDbXref , "PMID:2500773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033547 ; owl:annotatedTarget "Extracellular mesangial aggregates composed of non-branching fibrils, focally parralel over 30 nM in diameter. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033548 ; owl:annotatedTarget "Extracellular mesangial aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033549 ; owl:annotatedTarget "Lobular, round to oval mesangial lesions with an acellular hyaline/matrix core surrounded by compressed mesangial nuclei." . [] oboInOwl:hasDbXref , "PMID:26040776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033550 ; owl:annotatedTarget "A granuloma that is associated with necrotic changes. Caseation necrosis is defined as a region in granulomas with eosinophilic, granular and cheese-like cellular debris with necrosis. The word caseous itself means pertaining or related to cheese, and comes from the Latin word caseus, meaning cheese." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033551 ; owl:annotatedTarget "A granuloma located in the lung that is not associated with necrotic changes." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033552 ; owl:annotatedTarget "Villitis of unknown aetiology" . [] oboInOwl:hasDbXref , "PMID:31751017" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033553 ; owl:annotatedTarget "Embolization of intravascular thrombus containing microorganisms into the distant tissues via arterial system." . [] oboInOwl:hasDbXref , "PMID:30938432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033554 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against the Mi-2 antigen." . [] oboInOwl:hasDbXref , "PMID:1522616", "PMID:15804706" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033555 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against Ro/SSA autoantigens." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033556 ; owl:annotatedTarget "Anti-p62 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:9463400" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033557 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against proteinase 3. Proteinase 3 (PR3) antigen is a 29-kD serine protease that exists as a protein triplet in human neutrophils" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033557 ; owl:annotatedTarget "Anti-PR3 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:15096389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033558 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone antigens." . [] oboInOwl:hasDbXref , "PMID:30767872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033559 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against myeloperoxidase." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_47042 ; owl:annotatedTarget "hydroxycalciol" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033559 ; owl:annotatedTarget "Anti-MPO antibody positivity" . [] oboInOwl:hasDbXref , "PMID:17643929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033560 ; owl:annotatedTarget "Anti-PM-Scl antibodies target components of RNA-processing exosome complex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100, PM/Scl-75, hRrp4, hRrp42, hRrp46, hCs14, hRrp41, and hRrp40." . [] oboInOwl:hasDbXref , "PMID:31508255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033561 ; owl:annotatedTarget """The presence of autoantibodies in the blood circulation that react against bactericidal/permeability-increasing protein (BPI). BPI is an endotoxin-binding host protein with important antibacterial effects against Gram-negative bacteria, such as Pseudomonas aeruginosa. BPI is a 55 kDalton protein that is most abundant in the azurophilic granules of neutrophils. BPI also acts as a target antigen for antineutrophil cytoplasmic autoantibodies.""" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033561 ; owl:annotatedTarget "Anti-BPI antibody positivity" . [] oboInOwl:hasDbXref , "PMID:23814122" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033562 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against glycoprotein-210." . [] oboInOwl:hasDbXref , "PMID:33259121" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033563 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033563 ; owl:annotatedTarget "Anti-tTG antibody positivity" . [] oboInOwl:hasDbXref , "PMID:28063094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033564 ; owl:annotatedTarget "Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus." . [] oboInOwl:hasDbXref "PMID:18503599" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033565 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against epidermal transglutaminase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033565 ; owl:annotatedTarget "Anti-eTG antibody positivity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47042 ; owl:annotatedTarget "hydroxycalciols" . [] oboInOwl:hasDbXref "PMID:29262101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033566 ; owl:annotatedTarget "Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization." . [] oboInOwl:hasDbXref "PMID:29262101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033567 ; owl:annotatedTarget "A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between +90 degrees and 180 degrees, or beyond +100 degrees if the adult range is used." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033567 ; owl:annotatedTarget "RAD" . [] oboInOwl:hasDbXref "PMID:29262101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033568 ; owl:annotatedTarget "A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between -30 degrees and -90 degrees." . [] oboInOwl:hasDbXref "PMID:29262101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033569 ; owl:annotatedTarget "A kind of abnormal ventricular axis in the EKG whereby the QRS axis fall sbetween -90 degrees and 180 degrees. In this case, the ventricular vector is directed upward and to the right." . [] oboInOwl:hasDbXref "PMID:29262101" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033570 ; owl:annotatedTarget "A kind of abnormal ventricular axis in the EKG whereby the QRS complex is isoelectric or equiphasic in all leads with no dominant QRS deflection." . [] oboInOwl:hasDbXref , "PMID:16267251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033571 ; owl:annotatedTarget "The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033572 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone H1." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033573 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone H4." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033574 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone H3." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47042 ; owl:annotatedTarget "hydroxycholecalciferol" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033575 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone H2A." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033576 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against histone H2B." . [] oboInOwl:hasDbXref , "PMID:15194174", "PMID:15194175", "PMID:16899857", "PMID:6148159" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033577 ; owl:annotatedTarget "Localized thrombosis in pulmonary arteries frequently found in patients with idiopathic and hereditary pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease." . [] oboInOwl:hasDbXref , "PMID:30545968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033578 ; owl:annotatedTarget "Pre-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary vascular resistance (PVR 3 Wood units or more) accompanied by normal pulmonary artery wedge pressure (PAWP not more than 15 mmHg)." . [] oboInOwl:hasDbXref "PMID:21651393" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033579 ; owl:annotatedTarget "Insufficient growth hormone secretion following administration of growth hormone-releasing hormone." . [] oboInOwl:hasDbXref "PMID:15961865", "PMID:26744834" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033580 ; owl:annotatedTarget "An abnormal finding in a compound motor action potential measurement in EMG. Nerve conduction studies involve the application of a depolarising square wave electrical pulses to the skin over a peripheral nerve producing: (1) a propagated nerve action potential (NAP) recorded at a distant point over the same nerve: and (2) a compound muscle action potential (CMAP) arising from the activation of muscle fibres in a target muscle supplied by the nerve. In both cases these may be recorded with surface or needle electrodes. The CMAP is a summated voltage response from the individual muscle fibre action potentials. The shortest latency of the CMAP is the time from stimulus artefact to onset of the response and is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV)." . [] oboInOwl:hasDbXref , "PMID:32040879", "PMID:32047693" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033583 ; owl:annotatedTarget "Follicular bronchiolitis is a polyclonal hyperplasia of bronchiolar associated lymphoid tissue characterized by the is characterized by the development of lymphoid follicles with germinal centers in walls of the small airways." . [] oboInOwl:hasDbXref , "PMID:30085516" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033584 ; owl:annotatedTarget "Temporally uniform (all lesions are in the same stage of evolution) pattern of diffuse inflammatory interstitial process, mostly symmetric over the entire lung, involving mainly the alveolar septa." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033584 ; owl:annotatedTarget "NSIP" . [] oboInOwl:hasDbXref , "PMID:30085516rdfs:comment" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033585 ; owl:annotatedTarget "A type of non-specific interstitial pneumonia in which interstitial thickening is due to uniform dense or loose fibrosis and mild chronic inflammation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47042 ; owl:annotatedTarget "hydroxycholecalciferols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033586 ; owl:annotatedTarget "A type of non-specific interstitial pneumonia in which interstitial thickening is mainly due to infiltration of inflammatory cells and type II pneumocyte hyperplasia." . [] oboInOwl:hasDbXref "PMID:27617247" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033587 ; owl:annotatedTarget "A circumscribed area of pus or necrotic debris in the vulvar region." . [] oboInOwl:hasDbXref "PMID:17364294", "PMID:29262197" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033588 ; owl:annotatedTarget "Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline." . [] oboInOwl:hasDbXref "PMID:27275398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033589 ; owl:annotatedTarget "Passage of excessive amounts of gas and the feeling of abdominal fullness and bloating." . [] oboInOwl:hasDbXref "PMID:23537455" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033590 ; owl:annotatedTarget "A circumscribed area of pus or necrotic debris in the groin (inguinal region)." . [] oboInOwl:hasDbXref "PMID:29658394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033591 ; owl:annotatedTarget "Large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system." . [] oboInOwl:hasDbXref , "PMID:1864977", "PMID:3874029", "PMID:7986226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033592 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against the H3-H4 histone dimer." . [] oboInOwl:hasDbXref , "PMID:7986226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033593 ; owl:annotatedTarget "The presence of autoantibodies in the blood circulation that react against the H2A-H2B histone dimer." . [] oboInOwl:hasDbXref "PMID:9585615" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033594 ; owl:annotatedTarget "An abnormally increased amount of 7-biopterin in the urine." . [] oboInOwl:hasDbXref "PMID:17073606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033595 ; owl:annotatedTarget "Increased concentration of globotriaosylceramide (Gb3) in the blood circulation. Globotriaosylceramide, also named ceramidetrihexoside, is the primary lipid storage in Fabry disease." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47773 ; owl:annotatedTarget "VLDL cholesterol" . [] oboInOwl:hasDbXref "PMID:16329100" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033597 ; owl:annotatedTarget "Reduced activity of the linked disaccharidase, sucrase-isomaltase, which is a glycoprotein localized to the brush border membrane of small intestinal villi." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033598 ; owl:annotatedTarget "Fibrillar deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref , "PMID:25852856" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033599 ; owl:annotatedTarget "A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033600 ; owl:annotatedTarget "A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref , "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033601 ; owl:annotatedTarget "A type of glomerular subepithelial deposit characterized by finely granular material deposited between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM and corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033602 ; owl:annotatedTarget "A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref "PMID:30085237" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033603 ; owl:annotatedTarget "Deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature may be associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate)." . [] oboInOwl:hasDbXref "PMID:32866505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033604 ; owl:annotatedTarget "Glomerulus showing markedly and irregularly thickened capillary walls with massive fuchsinophilic subendothelial deposits, resulting in narrowing of capillary lumina. This feature is said to resemble a wire loop." . [] oboInOwl:hasDbXref "PMID:25805031" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033605 ; owl:annotatedTarget "A rash composed of pustular lesions. A pustule is defined as a vesicle or bulla containing purulent material. It varies in size and may occur at different levels within the epidermis: subcorneal, intraepidermal, or basement membrane zones. The pustules may or may not be sterile and are normally filled with neutrophils." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033606 ; owl:annotatedTarget "Haematopoietic maturation arrest" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47773 ; owl:annotatedTarget "VLDL-C" . [] oboInOwl:hasDbXref "PMID:26456767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033607 ; owl:annotatedTarget "A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow." . [] oboInOwl:hasDbXref , "PMID:26977460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033608 ; owl:annotatedTarget "Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033608 ; owl:annotatedTarget "Spot on the lung" . [] oboInOwl:hasDbXref "PMID:29143191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033609 ; owl:annotatedTarget "A type of pulmonary nodule whose density obscures the underlying parenchyma and thus has a \"solid\" appearance." . [] oboInOwl:hasDbXref "PMID:24100062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033610 ; owl:annotatedTarget "Pulmonary subsolid nodules (SSNs) refer to pulmonary nodules with pure ground-glass nodules and part-solid ground-glass nodules. A ground-glass nodule (GGN) is the morphologic description of a pulmonary nodule category on thin-section chest computed tomography (CT). During the past decade, the natural history, management strategy and long-term prognosis in the case of GGNs have attracted attention." . [] oboInOwl:hasDbXref , "PMID:24100062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033611 ; owl:annotatedTarget "Part-solid pulmonary nodules are nodules that present with both ground-glass and solid components in which the underlying lung architecture cannot be visualized." . [] oboInOwl:hasDbXref , "PMID:24100062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033612 ; owl:annotatedTarget "Pure ground-glass pulmonary nodules (GGNs) are defined as focal nodular areas of increased lung attenuation through which lung parenchymal structures, such as the pulmonary vessels or bronchial structures, can be observed." . [] oboInOwl:hasDbXref , "PMID:20177105" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033613 ; owl:annotatedTarget "Solid, homogenous nodules characterised by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes." . [] oboInOwl:hasDbXref , "PMID:11158647", "PMID:19332762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033614 ; owl:annotatedTarget "Aberrant or accessory bronchus supplying the upper lobe originating from the lateral wall of the trachea. The tracheal bronchus is more commonly right-sided, has a variable length and may be blind-ended. Two common types of tracheal bronchus are: supernumerary and displaced." . [] oboInOwl:hasDbXref , "PMID:11158647", "PMID:19332762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033615 ; owl:annotatedTarget "Accessory bronchus originating from trachea replacing one of the segmental branches of the anatomically normal upper lobe bronchus." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47773 ; owl:annotatedTarget "pre-beta-lipoprotein cholesterol" . [] oboInOwl:hasDbXref , "PMID:11158647" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033616 ; owl:annotatedTarget "Accessory bronchus originating from the medial wall of the right or left ban bronchus or bronchus intermedius. A cardiac bronchus is usually blind-ended." . [] oboInOwl:hasDbXref , "PMID:11158647", "PMID:19332762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033617 ; owl:annotatedTarget "Accessory bronchus which exits the trachea in addition to an anatomically normal branching upper lobe bronchus." . [] oboInOwl:hasDbXref , "PMID:11158647", "PMID:19332762" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033618 ; owl:annotatedTarget "Accessory entire right upper lobe bronchial system originating from the trachea with absent anatomically normal upper lobe bronchus." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033619 ; owl:annotatedTarget "A perifissural nodule that has contact with the interlobar septum (and is therefore considered typical)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033620 ; owl:annotatedTarget "A perifissural nodule that does not have contact with the interlobar septum (and is therefore considered atypical)." . [] oboInOwl:hasDbXref , "PMID:18544671", "PMID:27867581" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033621 ; owl:annotatedTarget "Bronchial diverticula are blind-ended outpouchings arising from the bronchial tree. They are commonly pulsion diverticula acquired related to chronic cough. Subcarinal air cyst is thought to represent a small main bronchial diverticulum." . [] oboInOwl:hasDbXref "PMID:31736939" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033622 ; owl:annotatedTarget "A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin." . [] oboInOwl:hasDbXref "PMID:29503048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033624 ; owl:annotatedTarget "A congenital cytomegalovirus (CMV) infection of the newborn can follow either a primary or recurrent maternal infection. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. Affected infants may develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits." . [] oboInOwl:hasDbXref "PMID:7809306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033625 ; owl:annotatedTarget "A feeling of general unease or nervousness that may be triggered by a sense of vulnerability or instability which is perceived as threatening." . [] oboInOwl:hasDbXref "HPO_CONTRIBUTOR:RGD_gthayman", "PMID:1596847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033626 ; owl:annotatedTarget "Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47774 ; owl:annotatedTarget "LDL cholesterol" . [] oboInOwl:hasDbXref "PMID:31085196" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033627 ; owl:annotatedTarget "Concentration of harderoporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "OMIM:ahamosh" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033628 ; owl:annotatedTarget "Intermittent abdominal pain with diarrhea and/or constipation." . [] oboInOwl:hasDbXref "PMID:29483905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033629 ; owl:annotatedTarget "The presence of an antibody of subclass IgG4 in the blood circulation that is directed against the organism's own cells or tissues." . [] oboInOwl:hasDbXref "PMID:23999934", "PMID:30452327", "PMID:32857796", "PMID:32984564", "PMID:33199820" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033630 ; owl:annotatedTarget "Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is \"cloudy\". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47774 ; owl:annotatedTarget "LDL-C" . [] oboInOwl:hasDbXref "PMID:22859929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033631 ; owl:annotatedTarget "Inflammation of the vertebrae (vertebral bodies) or spine." . [] oboInOwl:hasDbXref , "PMID:25706496", "PMID:28049168" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033632 ; owl:annotatedTarget "Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath manouver. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi*(Fi tracer/Fa tracer). In this equation, Vi = inspired volume of tracer gas, Fi tracer= inspired fraction of tracer gas, Fa tracer = alveolar (exhaled) fraction of tracer gas." . [] oboInOwl:hasDbXref , "PMID:30545968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033635 ; owl:annotatedTarget "Post-capillary pulmonary hypertension is a hemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP greater than 20 mmHg) and pulmonary artery wedge pressure (PAWP greater than 15 mmHg) and pulmonary vascular resistance (PVR less than 3 Wood units)." . [] oboInOwl:hasDbXref , "PMID:30545968" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033636 ; owl:annotatedTarget "Combined pre- and post-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary artery wedge pressure (PAWP over 15 mmHg) and pulmonary vascular resistance (PVR at least 3 Wodd units)." . [] oboInOwl:hasDbXref , "PMID:9518950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033637 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endomysial tissue transglutaminase 2 (tTG2)." . [] oboInOwl:hasDbXref , "PMID:18195376", "PMID:27852954" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033638 ; owl:annotatedTarget "Intralobular septal thickening is a computed tomography finding of increased width of the walls (septa) within a pulmonary lobule. Secondary pulmonary lobules represent a cluster of up to 30 acini 9 supplied by a common distal pulmonary artery and bronchiole. These clustered acini are bounded by interstitial fibrous septa (interlobular septa) which outline an irregular polyhedron of varying size between 1 and 2.5 cm. Interlobular septal thickening is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases. In contrast, intralobular septal thickening are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened. When numerous, they may appear as a fine reticular pattern." . [] oboInOwl:hasDbXref , "PMID:12244005" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033639 ; owl:annotatedTarget "Embolization of intravascular thrombus containing microorganisms into the pulmonary parenchyma via arterial system. Septic pulmonary embolism (PE) can be associated with multiple additional clinical manifestations such as fever, tachypnea, and hemoptysis. This HPO term refers to the finding of the septic embolus in the lung, which can be inferred from radiological findings. Typical radiographic features of septic PE include patchy air space lesions simulating non-specific bronchopneumonia; multiple ill defined round or wedge shaped densities of varying sizes from approximately 0.5 to 3.5 cm located peripherally; lesions abutting the pleura and located at the end of vessels (feeding vessel sign) seen on chest CT scans. Other pulmonary features suggesting septic PE include bilateral, occasional unilateral, rapid progression of cavities or abscess formations." . [] oboInOwl:hasDbXref "PMID:8793927" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033640 ; owl:annotatedTarget "Erosion (loss of substance) of the acetabular subchondral cortical bone. The acetabulum is the concave surface that meets with the head of the femur, forming the hip joint." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47774 ; owl:annotatedTarget "beta-lipoprotein cholesterol" . [] oboInOwl:hasDbXref , "PMID:22896576" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033641 ; owl:annotatedTarget "Deposition of calcium salts in the leaflets (cusps) of the aortic valve." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47775 ; owl:annotatedTarget "HDL cholesterol" . [] oboInOwl:hasDbXref "PMID:9345094" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033643 ; owl:annotatedTarget "Increased concentation of very long-chain fatty acids in the blood circulation. Very long-chain fatty acids are fatty acids (FAs) with a chain-length of 22 or more carbons." . [] oboInOwl:hasDbXref "PMID:30725682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033644 ; owl:annotatedTarget "Increased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production." . [] oboInOwl:hasDbXref "PMID:19933510", "PMID:32779696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033645 ; owl:annotatedTarget "A developmental defect characterized by an abnormal cleft (V-shaped indentation of the stalklike part of the brain consisting of the medulla oblongata, the midbrain, and the pons." . [] oboInOwl:hasDbXref "PMID:28250456" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033646 ; owl:annotatedTarget "Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033647 ; owl:annotatedTarget "The silhouette sign is the absence of depiction of an anatomic soft-tissue border. It is caused by consolidation and/or atelectasis of the adjacent lung, by a large mass, or by contiguous pleural fluid. The silhouette sign results from the juxtaposition of structures of similar radiographic attenuation. The sign actually refers to the absence of a silhouette." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033648 ; owl:annotatedTarget "A pseudocavity appears as an oval or round area of low attenuation in lung nodules, masses, or areas of consolidation that represent spared parenchyma, normal or ectatic bronchi, or focal emphysema rather than cavitation. These pseudocavities usually measure less than 1 cm in diameter. They have been described in patients with adenocarcinoma, bronchioloalveolar carcinoma, and benign conditions such as infectious pneumonia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47775 ; owl:annotatedTarget "HDL-C" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033649 ; owl:annotatedTarget "Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033650 ; owl:annotatedTarget """A parenchymal band is a linear opacity, usually 1-3 mm thick and up to 5 cm long that usually extends to the visceral pleura (which is often thickened and may be retracted at the site of contact). It reflects pleuroparenchymal fibrosis and is usually associated with distortion of the lung architecture. Parenchymal bands are most frequently encountered in individuals who have been exposed to asbestos.""" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033651 ; owl:annotatedTarget "A mycetoma is a discrete mass of intertwined hyphae, usually of an Aspergillus species, matted together by mucus, fibrin, and cellular debris colonizing a cavity, usually from prior fibrocavitary disease (eg, tuberculosis or sarcoidosis). A mycetoma may move to a dependent location when the patient changes position and may show an air crescent sign. CT scans may show a spongelike pattern and foci of calcification in the mycetoma." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033651 ; owl:annotatedTarget "Lung fungus ball" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033652 ; owl:annotatedTarget "A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway, most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans. Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033653 ; owl:annotatedTarget "A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (eg, bronchial atresia) or acquired (eg, obstructing cancer). A bronchocele is a tubular or branching Y-or V-shaped structure that may resemble a gloved finger. The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (eg, high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033654 ; owl:annotatedTarget "Irregular and nodular thickening of interlobular septa reminiscent of a row of beads." . [] oboInOwl:hasDbXref "PMID:18195376", "PMID:29518379" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033655 ; owl:annotatedTarget "A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033656 ; owl:annotatedTarget "A juxtaphrenic peak is a small triangular opacity based at the apex of the dome of a hemidiaphragm, associated with upper lobe volume loss of any cause (eg, postirradiation fibrosis or upper lobectomy). It is most readily appreciated on a frontal chest radiograph. The peak is caused by upward retraction of the inferior accessory fissure or an intrapulmonary septum associated with the pulmonary ligament." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033657 ; owl:annotatedTarget "Linear atelectasis is a focal area of subsegmental atelectasis with a linear configuration, almost always extending to the pleura. It is commonly horizontal but sometimes oblique or vertical. The thickness of the atelectasis may range from a few millimeters to more than 1 cm." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47775 ; owl:annotatedTarget "alpha-lipoprotein cholesterol" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033658 ; owl:annotatedTarget "Rounded atelectasis is rounded collapsed lung associated with invaginated fibrotic pleura and thickened and fibrotic interlobular septa. Most frequently, it is the consequence of an asbestos-induced exudative pleural effusion with resultant pleural scarring, but it may occur with any cause of pleural fibrosis. On chest radiographs, rounded atelectasis appears as a mass abutting a pleural surface, usually in the posterior part of a lower lobe. Distorted vessels have a curvilinear disposition as they converge on the mass (the comet tail sign). The degree of lobar retraction depends on the volume of atelectatic lung. It is almost invariably associated with other signs of pleural fibrosis (eg, blunting of costophrenic angle). CT is more sensitive for the detection and display of the characteristic features of rounded atelectasis. An additional sign is homogeneous uptake of contrast medium in the atelectatic lung." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033660 ; owl:annotatedTarget "Hand tingling" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033661 ; owl:annotatedTarget "An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass. The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis. However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033662 ; owl:annotatedTarget "An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung. The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (eg, pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (eg, lymphoma)." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033663 ; owl:annotatedTarget "Air trapping is retention of air in the lung distal to an obstruction (usually partial). Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse." . [] oboInOwl:hasDbXref , "PMID:25408925" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033664 ; owl:annotatedTarget "Gangliogliomas are rare tumors of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumors consisting of both dysplastic neuronal and neoplastic glial cells." . [] oboInOwl:hasDbXref "PMID:18638419", "PMID:19282701" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033665 ; owl:annotatedTarget "A reduction in an individual's subjective assessment of his or her sense of well-being and ability to perform social roles." . [] oboInOwl:hasDbXref "PMID:22654934", "PMID:26043341" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033667 ; owl:annotatedTarget "A reduction in the subjective feeling of mental well being." . [] oboInOwl:hasDbXref "PMID:29186501" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0033668 ; owl:annotatedTarget "The amygdala is a centrally located brain region that plays fundamental roles in human emotion, memory, and various homeostatic responses. Situated in the rostral part of the temporal lobe and abutting the basal forebrain, the human amygdala is closely connected with olfactory structures, the hippocampal formation, basal ganglia, basal forebrain components including ventral striatum and nucleus basalis, insula, claustrum, hypothalamus, and various thalamic nuclei. The amygdala contributes to white matter tracts that stream nearby, including the anterior commissure, inferior longitudinal fasciculus, stria terminalis, and uncinate fasciculus." . [] oboInOwl:hasDbXref , "PMID:12933928", "PMID:21047879", "PMID:33044668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033669 ; owl:annotatedTarget "A increase in the volume (size) of the amygdyla." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_47778 ; owl:annotatedTarget "glyceride" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033670 ; owl:annotatedTarget "Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033671 ; owl:annotatedTarget "Oligemia is a reduction in pulmonary blood volume. Most frequently, this reduction is regional, but occasionally it is generalized. Regional oligemia is usually associated with reduced blood flow in the oligemic area. Oligemia appears as a regional or widespread decrease in the size and number of identifiable pulmonary vessels, which is indicative of less than normal blood flow." . [] oboInOwl:hasDbXref "PMID:21524035", "PMID:32310394" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033672 ; owl:annotatedTarget "The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve." . [] oboInOwl:hasDbXref "PMID:31773104" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033673 ; owl:annotatedTarget "The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033673 ; owl:annotatedTarget "Phalen manoeuvre" . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033674 ; owl:annotatedTarget "Pulmonary blood flow redistribution refers to any departure from the normal distribution of blood flow in the lungs that is caused by an increase in pulmonary vascular resistance elsewhere in the pulmonary vascular bed. Pulmonary blood flow redistribution is indicated by a decrease in the size and/or number of visible pulmonary vessels in one or more lung regions, with a corresponding increase in number and/or size of pulmonary vessels in other parts of the lung." . [] oboInOwl:hasDbXref "PMID:11253156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033675 ; owl:annotatedTarget "A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised." . [] oboInOwl:hasDbXref "PMID:26611143" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033676 ; owl:annotatedTarget "A behavioral or psychological symptom that typically occurs following exposure to one or more traumatic events. Posttraumatic stress disorder (PTSD) symptoms include intrusive recollections (re-experiencing the trauma in flashbacks, memories or nightmares); avoidant and numbing symptoms (including diminished emotions and avoidance of situations that are reminders of the traumatic event); and hyperarousal (including increased irritability, exaggerated startle reactions or difficulty sleeping or concentrating)." . [] oboInOwl:hasDbXref "PMID:28613773" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033677 ; owl:annotatedTarget "Acute respiratory distress syndrome (ARDS) is defined as an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033677 ; owl:annotatedTarget "ARDS" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_47778 ; owl:annotatedTarget "glycerides" . [] oboInOwl:hasDbXref "PMID:19797781" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033678 ; owl:annotatedTarget "The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033679 ; owl:annotatedTarget "Any structural anomaly of the red nucleus, a part of the midbrain involved in control of movement." . [] oboInOwl:hasDbXref , "PMID:23817572" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033680 ; owl:annotatedTarget "The most common form of astrocytoma (WHO Grade I) in childhood. These typically have MAPK signalling pathway abnormalities." . [] oboInOwl:hasDbXref , , "PMID:32644610" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033681 ; owl:annotatedTarget "Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG." . [] oboInOwl:hasDbXref , "PMID:30051528", "PMID:31535562" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033682 ; owl:annotatedTarget "Pleomorphic xanthoastrocytomas (PXA) are rare low-grade astrocytomas (WHO Grade II) typically found in the temporal lobe and classically presenting with epilepsy. PXA is an astrocytic neoplasm that most often presents in children or young adults but can also occur in adults. The diagnosis of anaplastic PXA is made based upon tumor histopathologic characteristics and requires increased proliferative activity (mitotic index at least 5 mitoses/10 HPF), which is associated with worse overall survival. In general, anaplastic PXAs acquire features of a more aggressive astrocytic neoplasm that can include increased proliferation, necrosis, microvascular proliferation, loss of pericellular reticulin, and increased infiltrative growth." . [] oboInOwl:hasDbXref "PMID:27199166" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033684 ; owl:annotatedTarget "Ay deviation from the normal distribution of fiber types in skeletal muscle. The skeletal muscle groups of the mammalian body are made up of bundles of muscle fibers. These fibers can be assigned to different Types, with characteristic movement rates, response to neural inputs, and metabolic styles. Skeletal muscle fibers are broadly classified as slow-twitch (type 1) and fast-twitch (type 2). Multiple fiber types are generally intermingled within a single muscle group, and different muscle groups have varying proportions of fiber types" . [] oboInOwl:hasDbXref "PMID:32715519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033685 ; owl:annotatedTarget "An abnormal distribution of muscle fiber types in muscle tissue. Human skeletal muscle contains at least two fiber types recognizable by histochemical techniques. In transverse sections of normal skeletal muscle, type 1 and type 2 fibers are distributed in a random fashion. Grouping of fibers of the same type can be seen in certain peripheral neuropathies, thought to be due to reinnervation of denervated muscle fibers by sprouting axons. With grouping, motor units enlarge. The fibers of a motor unit, which are normally scattered, come to lie adjacent to one another. Histochemical examination shows groups of muscle fibers of the same histochemical type." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033685 ; owl:annotatedTarget "Fibre type grouping" . [] oboInOwl:hasDbXref "PMID:32715519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033686 ; owl:annotatedTarget "Enlargment of mitochondria. Mitochondrial hypertrophy is not discernible by light microscopy. By electron microscopy (EM), hypertrophic mitochondria have normal cristae and normal matrix density. In contrast, swollen mitochondria display swollen cristae and irregular matrix densities in EM." . [] oboInOwl:hasDbXref "PMID:18394484", "PMID:31424720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033687 ; owl:annotatedTarget "A deficit in the retention of pieces of information (memory chunks) for a relatively short time (usually up to 30 seconds)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47778 ; owl:annotatedTarget "acylglycerols" . [] oboInOwl:hasDbXref "PMID:18394484", "PMID:31424720" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033688 ; owl:annotatedTarget "A deficit in the ability to retrieve information from long-term memory, which can be defined as a seemingly unlimited capacity to store memories can last years and relate to the performance of actions or skills (i.e., procedural memories, knowing how) and memories of facts, rules, concepts, and events (i.e., declarative memories, knowing that)." . [] oboInOwl:hasDbXref "PMID:24041667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033689 ; owl:annotatedTarget "The impaired ability to establish new long-term memories." . [] oboInOwl:hasDbXref "PMID:24041667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033690 ; owl:annotatedTarget "Inability to retrieve information from the long-term memory that was acquired before the onset of amnesia." . [] oboInOwl:hasDbXref "PMID:33524264" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033692 ; owl:annotatedTarget "Impaired ability to remember facts and events." . [] oboInOwl:hasDbXref "PMID:28334095" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033693 ; owl:annotatedTarget "Perception of an odor in the absence of any stimuli in the surrounding environment that could emit the odor." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033693 ; owl:annotatedTarget "Phantom odour" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033694 ; owl:annotatedTarget "Tactile hallucinations" . [] oboInOwl:hasDbXref "PMID:32348545", "PMID:33479703" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033696 ; owl:annotatedTarget "Acral areas of erythema with vesicles or pustules. The lesions resemble chilblains and have purpuric areas, affecting hands and feet." . [] oboInOwl:hasDbXref "PMID:33008676" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033697 ; owl:annotatedTarget "A type of acute-onset skin rash characterized by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point. The fluid contained in a vesicle may be clear, serous, or hemorrhagic." . [] oboInOwl:hasDbXref "PMID:32348545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033698 ; owl:annotatedTarget "A type of vesicular eruption in which the vesicles are at same stages." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47778 ; owl:annotatedTarget "glycerides" . [] oboInOwl:hasDbXref "PMID:32579185" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033700 ; owl:annotatedTarget "An acute onset rash characterized by by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevations with a diameter less than 10mm at the widest point, and by multiple papules, which are circumscribed, solid epidermal elevations with no visible fluid with a diameter less than 10mm at the widest point." . [] oboInOwl:hasDbXref "PMID:17404618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033701 ; owl:annotatedTarget "Increased density related to increased bone mass in the outermost layer (edge) of the iliac wing." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033702 ; owl:annotatedTarget "This finding is a thin curvilinear opacity, 1-3 mm in thickness, lying less than 1 cm from and parallel to the pleural surface. It corresponds to atelectasis of normal lung if seen in the dependent posteroinferior portion of lung of a patient in the supine position and is subsequently shown to disappear on CT sections acquired with the patient prone. It may also be encountered in patients with pulmonary edema or fibrosis (other signs are usually present)." . [] oboInOwl:hasDbXref , "PMID:25408925", "PMID:26493957" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033703 ; owl:annotatedTarget "Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Lesions vary in size from 10 to 25 mm, although occasionally larger tumors of up to 70 mm have been reported. Grossly, tumors appear as well-defined, solitary nodular masses or poorly demarcated lesions. On the cut section, most tumors are cortically located and may extend into the underlying subcortical white matter in larger tumors. Multi-nodular appearance or cystic changes are commonly found" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033703 ; owl:annotatedTarget "DNET" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033703 ; owl:annotatedTarget "DNT" . [] oboInOwl:hasDbXref "PMID:32809406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033704 ; owl:annotatedTarget "An increased amount of homogentisic acid in the urine." . [] oboInOwl:hasDbXref "PMID:33345598" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033705 ; owl:annotatedTarget "A feeling of sadness characterized by crying episodes that can come on suddenly and are not under usual social control." . [] oboInOwl:hasDbXref "PMID:18195376" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033706 ; owl:annotatedTarget """This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in the upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis.""" . [] oboInOwl:hasDbXref "PMID:32965877" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033707 ; owl:annotatedTarget "Increased thickness of the stratum corneum (the outer layer of the skin) in the skin surrounding the mouth." . [] oboInOwl:source "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_47788 ; owl:annotatedTarget "PMID:9811880" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033708 ; owl:annotatedTarget "Anti-HMGCR autoantibodies" . [] oboInOwl:hasDbXref "PMID:16983448", "PMID:21121836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033709 ; owl:annotatedTarget "An increase in the amount of airway mucus. This feature may be characterized by frequent or excessive throat clearing (exhalation through tightly constricted laryngopharyngeal tissues accompanied by vibration of the palatoglossal arch and the vocal folds serving to clear mucus from the airway)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033709 ; owl:annotatedTarget "Increased phlegm" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033710 ; owl:annotatedTarget "Dyspnoea at rest" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033710 ; owl:annotatedTarget "Shortness of breath at rest" . [] oboInOwl:hasDbXref "PMID:22976427", "PMID:25473625" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033712 ; owl:annotatedTarget "Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles." . [] oboInOwl:hasDbXref "PMID:29582188", "PMID:30639649", "PMID:33093664" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033713 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against anti-signal recognition particle." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033713 ; owl:annotatedTarget "Anti-SRP antibody positivity" . [] oboInOwl:hasDbXref , "PMID:15635074" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033714 ; owl:annotatedTarget "The occurrence of multiple distinct meningiomas in the same individual." . [] oboInOwl:hasDbXref , "PMID:12117357", "PMID:24762203", "PMID:26060898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033715 ; owl:annotatedTarget "Hippocampal sclerosis is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47788 ; owl:annotatedTarget "3-Oxosteroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033717 ; owl:annotatedTarget "Focal epileptiform EEG discharges recorded in the temporal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033718 ; owl:annotatedTarget "Focal epileptiform EEG discharges recorded in the central region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033719 ; owl:annotatedTarget "Focal epileptiform EEG discharges recorded in the parietal region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033720 ; owl:annotatedTarget "Focal epileptiform EEG discharges recorded in the occipital region." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033721 ; owl:annotatedTarget "Focal epileptiform EEG discharges recorded in the centrotemporal region." . [] oboInOwl:hasDbXref , "PMID:20926350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033722 ; owl:annotatedTarget "An autonomic epileptic aura is a purely subjective manifestation of an epileptic seizure pertaining to autonomic nervous system function. Autonomic auras include cardiorespiratory (e.g., palpitations and shortness of breath), gastrointestinal, genitourinary (genital sensations, urinary urge), and cutaneous (feeling of warmth or cold) sensations. Abdominal auras constitute the most common type of autonomic aura. These include sensations of nausea, pain, or indescribable discomfort in the abdominal or periumbilical area that can be static, rise to the chest and throat, or descend into the lower abdominal region." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033722 ; owl:annotatedTarget "Autonomic auras" . [] oboInOwl:hasDbXref , "PMID:29923367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033724 ; owl:annotatedTarget "An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033725 ; owl:annotatedTarget "An abnormally thin corpus callous, due to atrophy, hypoplasia or agenesis. This term is intended to be used in situations where it is not known if thinning of the corpus callosum (for instance, as visualized by magnetic resonance tomography) is due to abnormal development (e.g. a leukodystrophy) or atrophy following normal development (e.g. neurodegeneration)." . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033726 ; owl:annotatedTarget "Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47788 ; owl:annotatedTarget "3-oxo steroids" . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033727 ; owl:annotatedTarget "A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations." . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033728 ; owl:annotatedTarget "A subclass of lupus nephritis with purely mesangial hypercellularity of any degree or mesangial matrix expansion by lightmicroscopy, with mesangial immune deposits. A few isolated subepithelial or subendothelial deposits may be visible by immunoflourescence or electron microscopy, but not by light microscopy." . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033729 ; owl:annotatedTarget "A subclass of lupus nephritis with normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence." . [] oboInOwl:hasDbXref "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033730 ; owl:annotatedTarget "A lupus nephritis subclass with global or segmental subepithelial immune deposits or their morphological sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. May occur in combination with class III or IV, in which case both classes are diagnosed. May show advanced sclerosis" . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033731 ; owl:annotatedTarget "A subclass of lupus nephritis with active or inactive focal, segmental or global endocapillary or extracapillary glomerulonephritis involving less than 50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations" . [] oboInOwl:hasDbXref , "PMID:31974366" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033732 ; owl:annotatedTarget "A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity." . [] oboInOwl:hasDbXref , "PMID:18322164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033733 ; owl:annotatedTarget "Vesicoureteral reflux without dilation of the renal calyces (Grade I-II)." . [] oboInOwl:hasDbXref , "PMID:18322164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033734 ; owl:annotatedTarget "Vesicoureteral reflux with dilation of the renal calyces (Grade III - V)." . [] oboInOwl:hasDbXref , "PMID:18322164" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033735 ; owl:annotatedTarget "Vesicoureteral reflux into the ureter only." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033735 ; owl:annotatedTarget "Grade I VUR" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47788 ; owl:annotatedTarget "3-oxosteroids" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033735 ; owl:annotatedTarget "VUR I" . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:3975102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033736 ; owl:annotatedTarget "Vesicoureteral reflux into a non-dilated pyelocalyceal system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033736 ; owl:annotatedTarget "Grade II VUR" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033736 ; owl:annotatedTarget "VUR II" . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:3975102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033737 ; owl:annotatedTarget "Vesicoureteral reflux with dilatation of the collecting system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033737 ; owl:annotatedTarget "Grade III VUR" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033737 ; owl:annotatedTarget "VUR III" . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:19668250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033738 ; owl:annotatedTarget "Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction." . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:19668250" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033739 ; owl:annotatedTarget "Vesicoureteral reflux induced by increased bladder pressures in patients with voiding dysfunction e.g. in case of congenital posterior urethral valves or neurogenic bladder dysfunction." . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:3975102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033740 ; owl:annotatedTarget "Vesicoureteral reflux with massive dilation of the collecting system and severe tortuosity of the ureter." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47788 ; owl:annotatedTarget "a 3-oxosteroid" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033740 ; owl:annotatedTarget "Grade V VUR" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033740 ; owl:annotatedTarget "VUR V" . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:3975102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033741 ; owl:annotatedTarget "Vesicoureteral reflux with more-extensive dilation with blunting of the calyces and tortuosity of the ureter." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033741 ; owl:annotatedTarget "Grade IV VUR" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033741 ; owl:annotatedTarget "VUR IV" . [] oboInOwl:hasDbXref , "PMID:18322164", "PMID:33738272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033742 ; owl:annotatedTarget "Severe vesicoureteral reflux reaching the kidney parenchyma." . [] oboInOwl:hasDbXref "PMID:26331051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033744 ; owl:annotatedTarget "A type of cerebellar dysplasia that affects the entire cerebellum." . [] oboInOwl:hasDbXref "PMID:26331051" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033745 ; owl:annotatedTarget "A type of cerebellar dysplasia that affects the upper part of the cerebellar vermis." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033746 ; owl:annotatedTarget "Pain between shoulder blades" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033748 ; owl:annotatedTarget "Hypoaesthesia" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033748 ; owl:annotatedTarget "Numbness" . [] oboInOwl:hasDbXref "PMID:29763183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033749 ; owl:annotatedTarget "A deviation from normal values for the functional residual capacity, which is defined as the volume remaining in the lungs after a normal, passive exhalation." . [] oboInOwl:hasDbXref "PMID:29763183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033750 ; owl:annotatedTarget "An abnormal reduction in the volume remaining in the lungs after a normal, passive exhalation." . [] oboInOwl:hasDbXref "PMID:29763183" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033751 ; owl:annotatedTarget "An abnormal increase in the volume remaining in the lungs after a normal, passive exhalation." . [] oboInOwl:hasDbXref "PMID:19159437", "PMID:29446315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033754 ; owl:annotatedTarget "Any deviation from the normal range of end-diastolic volume of the left ventricle, which is the volume of blood in the left ventricle at the end of diastole (just before systole)." . [] oboInOwl:hasDbXref "PMID:32490903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033757 ; owl:annotatedTarget "Fat infiltration in the pancreas." . [] oboInOwl:hasDbXref "PMID:7598776" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033758 ; owl:annotatedTarget "A circumscribed area of pus or necrotic debris in the labia." . [] oboInOwl:hasDbXref , "PMID:25287933" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033759 ; owl:annotatedTarget "Decreased renal tubular reabsorption of magnesium." . [] oboInOwl:hasDbXref "PMID:29506981" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033760 ; owl:annotatedTarget "Maximum oxygen uptake (VO2max) is defined as the highest rate of oxygen uptake and utilization by the body during intense, maximal exercise, whereby further increases in work rate do not bring on additional rises in VO2 (i.e. plateau). VO2Max is typically measured with a treadmill anad ergometer and the participant exercises with increasing levels of intensity. VO2Max is the point at which oxygen uptake no longer increases despite an increase in workload." . [] oboInOwl:hasDbXref , "PMID:21526966" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033761 ; owl:annotatedTarget "Xanthogranulomatous pyelonephritis is a granulomatous inflammatory infiltrate composed of neutrophils, lymphocytes, plasma cells, xanthomatous histiocytes, and multinucleated giant cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47857 ; owl:annotatedTarget "urea derivatives" . [] oboInOwl:hasDbXref "PMID:32310592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033762 ; owl:annotatedTarget "Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033764 ; owl:annotatedTarget "Death between the age of 40 and 60 years." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033765 ; owl:annotatedTarget "Death at an age of at least 60 years." . [] oboInOwl:hasDbXref "PMID:23814690" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033766 ; owl:annotatedTarget "Polymelia is a congenital anomaly, which is defined as the presence of accessory limbs attached to various body regions and could be classified as cephalomelia (extra-limb attached to the head), notomelia (extra-limb attached to the back bone), thoracomelia (extra-limb attached to the thorax), and pyromelia (extra-limb attached to the pelvis)." . [] oboInOwl:hasDbXref "PMID:15961866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033767 ; owl:annotatedTarget "Abnormally high or low single motor unit action potential reading (-Pk Amps)." . [] oboInOwl:hasDbXref "PMID:27659805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033768 ; owl:annotatedTarget "Overgrowth of candida albicans in the penis." . [] oboInOwl:hasDbXref "PMID:20567540" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033769 ; owl:annotatedTarget "Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps." . [] oboInOwl:hasDbXref "NCIT:C4004", "PMID:15621988", "PMID:28569272" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033770 ; owl:annotatedTarget "An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia." . [] oboInOwl:hasDbXref "PMID:28925655" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033771 ; owl:annotatedTarget "Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling." . [] oboInOwl:hasDbXref "PMID:12934788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033772 ; owl:annotatedTarget "Any deviation from the normal ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47867 ; owl:annotatedTarget "Indikator" . [] oboInOwl:hasDbXref "PMID:12934788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033773 ; owl:annotatedTarget "An abnormally low ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining after maximal expiration and TLC is the total amount of air in the lungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography." . [] oboInOwl:hasDbXref , "PMID:27105641", "PMID:31474092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033774 ; owl:annotatedTarget "Decreased renal tubular reabsorption of uric acid." . [] oboInOwl:hasDbXref "PMID:31802270" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033775 ; owl:annotatedTarget "An abnormal pulmonary imaging finding defined by eponym or reference to signs, symbols, or naturalistic images." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033776 ; owl:annotatedTarget "Small nodules of enamel on the root of a tooth." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033777 ; owl:annotatedTarget "Additional cusps of a dental crown." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033778 ; owl:annotatedTarget "An additional cusp located in the middle of the occlusal surface." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033779 ; owl:annotatedTarget "A tooth crown with convex mesial and distal surfaces." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033780 ; owl:annotatedTarget "A tooth crown with a marked cervical area constriction." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033781 ; owl:annotatedTarget "A tooth with a crown that narrows from proximal toward the incisal edge. Tapering of teeth typically involves incisors." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033783 ; owl:annotatedTarget "Molar incisor malfomation (MIM) is composed of normal crown with marked cervical constriction, thin, narrow short roots which is a combination of signs that occurs in deciduous and permanent molars." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47868 ; owl:annotatedTarget "photosensitising agent" . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033784 ; owl:annotatedTarget "This is a bundled term as dentin dysplasia is composed of short roots with pointed ends and taurodontism and intrapulpal calcifications." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033785 ; owl:annotatedTarget "Complete or almost complete absence of enamel." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033786 ; owl:annotatedTarget "Enamel with a white or brown discoloration without hypoplasia." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033787 ; owl:annotatedTarget "The decrease or absence of cementum. The cementum anchors the periodontal ligament attachment fiber between the tooth root and the alveolar bone. Its absence leads to early loss of teeth." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033788 ; owl:annotatedTarget "Excess of cementum on the tooth root surface." . [] oboInOwl:hasDbXref "PMID:9398858" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033789 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by eating cheese." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033790 ; owl:annotatedTarget "A thistle tube shape of the pulp chamber, meaning an enlarged coronal pulp chamber with narrow pulp canals giving a radiographic appearance of the shape of a thistle tube or a flame. It may occur isolated or associated with other dental anomalies and rare diseases such as dentinogenesis imperfecta, which should be assessed and coded separately. The diagnosis thistle tube shape pulp requires clinical and radiographic examinations." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033791 ; owl:annotatedTarget "Fusion of a tooth with alveolar bone." . [] oboInOwl:hasDbXref "PMID:31468724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033792 ; owl:annotatedTarget "Lingual occlusion of buccal cusps and/or incisal edge of maxillary teeth to the buccal cusps and/or incisal edge of mandibular teeth." . [] oboInOwl:hasDbXref "PMID:27477558", "PMID:27812777", "PMID:30853479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033794 ; owl:annotatedTarget "Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargment, glove tightness, and hand enlargement." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47880 ; owl:annotatedTarget "steroid esters" . [] oboInOwl:hasDbXref "PMID:28443260" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0033795 ; owl:annotatedTarget "Growth hormone (GH) is essential for normal growth. However, cases of normal growth without GH may occur. The mechanism of growth without GH remains still unclear. However, regarding normal growth without GH arising after brain surgery, hypothalamic damage caused by the brain surgery is thought to induce obesity, and the resulting hyperinsulinemia and/or hyperprolactinemia are assumed to be important mechanisms of normal growth without GH in postsurgery patients. It is assumed that elevated insulin and/or prolactin concentration normalize IGF-1 levels even in GHD patients, restricts the increase in serum levels of IGFBP-3, and changes the distribution of circulating IGF-1. Thus, normal growth without GH continues because of the effects of IFG-I, which are independent of GH." . [] oboInOwl:hasDbXref "PMID:23351991" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033798 ; owl:annotatedTarget "During states of inflammation, white blood cells (leukocytes) play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. This term refers to a defect in the attachment of leukocytes to the blood vessel wall, which is a key step required before they can pass through gaps of the endothelial cells of the blood vessel wall to migrate to the site of inflammation." . [] oboInOwl:hasDbXref "PMID:20055907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033801 ; owl:annotatedTarget "Blistering (presence of multiple fluid filled blisters) categorized according to the layer of the skin in which the blister originates. The skin is divided into three layers. The epidermis (outermost layer, which mainly consists of keratinocytes), the dermis, and a subcutaneous layer. The epidermis is divided into five layers: the basal lamina (innermost layer), the basal cell layer, the stratum spinosum, the stratum granulosum, and the stratum corneum (outermost layer). Cleavage in epidermolysis bullosa (EB) simplex occurs within the basal keratinocytes; in junctional EB, within the lamina lucida; and in dystrophic EB occurs in the sublamina densa, in the upper portion of the dermis (papillary dermis). In Kindler's EB, cleavage can occur in the basal keratinocytes, in the lamina lucida, or below the lamina densa." . [] oboInOwl:hasDbXref "PMID:32476832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033805 ; owl:annotatedTarget "A granuloma which is not associated with necrotic changes." . [] oboInOwl:hasDbXref "PMID:30725734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033807 ; owl:annotatedTarget "Lack of keratohyalin granules, which are normally present in the stratum granulosum of the epidermal layer of the skin." . [] oboInOwl:hasDbXref "PMID:21592287" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033808 ; owl:annotatedTarget "A cystic structure arising from the epididymis, rete testis or efferent ductuli. These structures are filled with spermatozoa containing fluid that may be milky. These cysts are usually outside the tunica vaginalis and, as with hydrocele, transluminate easily." . [] oboInOwl:hasDbXref "PMID:20301592", "PMID:31888681" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033810 ; owl:annotatedTarget "A reduced concentration of dihydrotestosterone in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033831 ; owl:annotatedTarget "Thick-walled abnormal gas-filled interstitial mass within a lung with a diameter greater than 30 mm." . [] oboInOwl:hasDbXref "PMID:17143977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033832 ; owl:annotatedTarget "A reddish-blue mottled condition of skin caused by inflammation of the cutaneous blood vessels." . [] oboInOwl:hasDbXref "PMID:32619646" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033833 ; owl:annotatedTarget "Increased concentration of the interleukin-2 receptor alpha-chain (CD25) in the blood circulation. CD25 is shed upon immune activation. Increased levels of soluble CD25, therefore, are an indication of an on-going immune response." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_47882 ; owl:annotatedTarget "macrocyclic polypyrroles" . [] oboInOwl:hasDbXref "PMID:17339971" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033840 ; owl:annotatedTarget "Uterine bleeding that occurs after at least one year of amenorrhea in a woman who is not receiving hormone therapy." . [] oboInOwl:hasDbXref "PMID:29862322", "PMID:29988128" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033841 ; owl:annotatedTarget "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching in the region of the eye." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033841 ; owl:annotatedTarget "Itchy eyes" . [] oboInOwl:hasDbXref "PMID:21369493", "PMID:27781342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033842 ; owl:annotatedTarget "The condition of being unable to eat a full meal because of a feeling of fullness (satiety), or or feeling very full after eating only a small amount of food." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033842 ; owl:annotatedTarget "Feeling full quickly when eating" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033842 ; owl:annotatedTarget "Not able to finish a normal-sized meal" . [] oboInOwl:hasDbXref "PMID:27781342" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033843 ; owl:annotatedTarget "Feeling excessively full after meals." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033844 ; owl:annotatedTarget "Racing thoughts" . [] oboInOwl:hasDbXref "PMID:18577027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033845 ; owl:annotatedTarget "A feeling that something life-threatening or tragic is about to occur." . [] oboInOwl:hasDbXref "PMID:23643384" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033846 ; owl:annotatedTarget "Reduced amount of myelin in the spinal cord resulting from defective myelinogenesis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47882 ; owl:annotatedTarget "cyclic polypyrroles" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033847 ; owl:annotatedTarget "Phantom taste" . [] oboInOwl:hasDbXref "PMID:28722980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033848 ; owl:annotatedTarget "A type of aphasia that is characterized by impaired language comprehension." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033848 ; owl:annotatedTarget "Fluent aphasia" . [] oboInOwl:hasDbXref "PMID:31024369" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033849 ; owl:annotatedTarget "The term bilingual aphasia is used to refer to aphasia in persons who speak two or more languages. When a multilingual speaker has aphasia following a stroke, the languages spoken premorbidly may show comparable or differential patterns of impairment. Differential patterns may manifest as greater impairment in one language compared to another, or as differences in the characteristics of aphasia. Clinical reports of bilingual aphasia show dissociations in the processing of the language learned first (L1) and and second (L2), with one language more impaired than the other. Other cases show a pattern of differential recovery where L2 is recovered only after L1. Another pattern is alternating antagonism; i.e., patients access one language in spontaneous speech and inhibit the other language for alternating periods. This term should be used for a type of aphasia in a person who speaks multiple languages in which the impairment is different for different languages." . [] oboInOwl:hasDbXref "PMID:16770929", "PMID:32491414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033850 ; owl:annotatedTarget "Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness." . [] oboInOwl:hasDbXref "PMID:18004962" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033851 ; owl:annotatedTarget "Elevation of the upper eyelid on attempted downward gaze or adduction, adduction of the eye on attempted upward or downward gaze, and constriction of the pupil on attempted adduction." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033852 ; owl:annotatedTarget "Abnormal structure of a vein located inside the kidney parenchyma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033853 ; owl:annotatedTarget "Any structural anomaly of the arcuate vein. The arcuate veins cross traverse along the corticomedullary junction (at the border of the kideny cortex and medulla)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033854 ; owl:annotatedTarget "Any structural anomaly of the interlobular veins of the kidney. An interlobular vein is surrounded by the renal cortex and located between renal lobules (consisting of the nephrons surrounding a single medullary ray and draining into a single collecting duct)." . [] oboInOwl:hasDbXref , "PMID:27012950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033856 ; owl:annotatedTarget "Needle-like or slit-like clefts within the interior space of interlobular veins. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47882 ; owl:annotatedTarget "polypyrrole macrocycles" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033857 ; owl:annotatedTarget "Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen of the interlobular veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033858 ; owl:annotatedTarget "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the interlobular veins of the kidney." . [] oboInOwl:hasDbXref , "PMID:21720964" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033861 ; owl:annotatedTarget "Duplicated basement membranes of the peritubular capillaries located in the cortex of the kidney and arranged in multiple concentric layers." . [] oboInOwl:hasDbXref , "PMID:25738252" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033862 ; owl:annotatedTarget "Inflammation of the peritubular capillaries in the cortex of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033863 ; owl:annotatedTarget "Abnormal structural characteristics of the interior space of the peritubular capillary in the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033864 ; owl:annotatedTarget "Anomalous structure of the peritubular capillaries located in the medulla of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033865 ; owl:annotatedTarget "Inflammation of the peritubular capillaries in the medulla of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells." . [] oboInOwl:hasDbXref , "PMID:28794065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033866 ; owl:annotatedTarget "Substantially increased numbers of red blood cells within capillaries surrounding tubules in the medulla of the kidney. This feature is assessed in histological images as the presence of numerous erythrocytes in a segment of the capillary such that the vessel appears to be congested (not open)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033867 ; owl:annotatedTarget "Duplicated basement membranes of the peritubular capillaries located in the medulla of the kidney and arranged in multiple concentric layers." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033869 ; owl:annotatedTarget "Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the medulla of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033870 ; owl:annotatedTarget "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the medulla of the kidney." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033871 ; owl:annotatedTarget "Organised thrombi within the medullary peritubular capillary lumen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033874 ; owl:annotatedTarget "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the cortex of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033875 ; owl:annotatedTarget "Abnormal structural characteristics of the interior space (lumen) of the arcuate vein of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033876 ; owl:annotatedTarget "Needle-like or slit-like clefts within the interior space of arcuate veins of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033877 ; owl:annotatedTarget "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033878 ; owl:annotatedTarget "Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate veins of the kidney." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033878 ; owl:annotatedTarget "Organised thrombi within arcuate vein lumen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033879 ; owl:annotatedTarget "Any structural anomaly located in the inner or middle layer of the arcuate veins of the kidney." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033880 ; owl:annotatedTarget "Intimal mucoid oedema within arcuate veins" . [] oboInOwl:source "LIPID MAPS" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "LIPID_MAPS_instance:LMSP0601AJ00" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47891 ; owl:annotatedTarget "steroid acids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033881 ; owl:annotatedTarget "Accumulation of myxoid material (mucus-like material) within the inner or middle layer of the arcuate vein of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033882 ; owl:annotatedTarget "Amorphous extracellular substance in the inner or middle layer of the arcuate veins of the kidney. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033885 ; owl:annotatedTarget "Needle-like or slit-like clefts within the interior space of cortical radial arteries (interlobular arteries) of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033887 ; owl:annotatedTarget "Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy" . [] oboInOwl:hasDbXref "PMID:29489242" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033889 ; owl:annotatedTarget "Any structural anomaly of the glomerular arterioles. The interlobar arteries of the kidney branch into arcuate arteries, cortical radiate arteries, and then into afferent arterioles. After passing through the renal corpuscle, the capillaries form the efferent arteriole. The afferent and efferent arterioles are difficult to distinguish histologically and are thus both included in this term and its descendents." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033890 ; owl:annotatedTarget "Abnormal structural characteristics of the interior space (lumen) of renal arterioles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033891 ; owl:annotatedTarget "Needle-like or slit-like clefts within the interior space of arterioles of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033892 ; owl:annotatedTarget "Any structural anomaly located in the inner or middle layer of the arterioles of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033894 ; owl:annotatedTarget "Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arterioles of the kidney." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033899 ; owl:annotatedTarget "Organised thrombi within arcuate arterial lumen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033900 ; owl:annotatedTarget "Amorphous extracellular substance in the inner or middle layer of renal arterioles. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033902 ; owl:annotatedTarget "Enlargement of endothelial cells of the arcuate arteries of the kidney because of cytoplasmic swelling." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033903 ; owl:annotatedTarget "Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the arcuate arteries of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033904 ; owl:annotatedTarget "Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material (hyalinosis) in the inner or middle layer of the renal arterioles. This feature may be accompanied by hypertrophy of the media and intima fibrosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033905 ; owl:annotatedTarget "Thickening of the intima of the arcuate arteries of the kidney with fibrosis and/or duplication of the elastic lamina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033906 ; owl:annotatedTarget "Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033907 ; owl:annotatedTarget "Thickening of the intima of renal arterioles with fibrosis and/or duplication of the elastic lamina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033908 ; owl:annotatedTarget "Atrophy (wasting, decreased thickness) of of the middle layer of the arterioles of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033909 ; owl:annotatedTarget "Increased thickness of middle layer of the arcuate veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033910 ; owl:annotatedTarget "Atrophy (wasting, decreased thickness) of the middle layer of the arcuate veins of the kidney." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47909 ; owl:annotatedTarget "3-Oxo-delta4-steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033912 ; owl:annotatedTarget "Atrophy (wasting, decreased thickness) of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033915 ; owl:annotatedTarget "Accumulation of edematous extracellular matrix in intima resembling mucus. This feature appears pale blue on hematoxylin and eosin staining." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033916 ; owl:annotatedTarget "Thickening of the intima with fibrosis and/or duplication of the elastic lamina in arcuate veins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033919 ; owl:annotatedTarget "Inflammation of the inner or middle layer of arcuate venules. This feature may involve only the intima or it can be transmural." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033921 ; owl:annotatedTarget "Abnormal and excessive number of cells (hypercellularity) in the lining (endothelium) of the arterioles of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033922 ; owl:annotatedTarget "A type of renal arteriole endoarterial hypercellularity due to increased number of white blood cells (leukocytes)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033923 ; owl:annotatedTarget "A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033924 ; owl:annotatedTarget "A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased numbers of neutrophils within the arteriolar lumen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033926 ; owl:annotatedTarget "Myointimal hyperplasia arranged in multiple concentric layers in the inner or middle layer of the arterioles of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033927 ; owl:annotatedTarget "Arcuate artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47909 ; owl:annotatedTarget "3-oxo Delta(4)-steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033928 ; owl:annotatedTarget "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033929 ; owl:annotatedTarget "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils withinin the lumen of arcuate artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033930 ; owl:annotatedTarget "A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of arcuate artery." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033931 ; owl:annotatedTarget "Death of tissue in the inner or middle layer of the arcuate artery of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033932 ; owl:annotatedTarget "A type of arcuate artery intima/media necrosis in which the necrotic tissue retains the outlines of the dead (necrotic) structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033933 ; owl:annotatedTarget "A type of arcuate artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033934 ; owl:annotatedTarget "Accumulation of material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arcuate veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033935 ; owl:annotatedTarget "Cell death (necrosis) in the inner or middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033936 ; owl:annotatedTarget "A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033937 ; owl:annotatedTarget "A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47909 ; owl:annotatedTarget "3-oxo Delta(4)-steroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033938 ; owl:annotatedTarget "Cell death (necrosis) in the inner or middle layer of the arterioles of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033940 ; owl:annotatedTarget "A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033941 ; owl:annotatedTarget "A type of renal intimal/medial arteriolitis characteriezed by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033943 ; owl:annotatedTarget "A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033944 ; owl:annotatedTarget "A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033945 ; owl:annotatedTarget "A type of arcuate intimal/medial venulitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033946 ; owl:annotatedTarget "Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arcuate veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033948 ; owl:annotatedTarget "Inflammation of the inner or middle layer of the arcuate arteries of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033950 ; owl:annotatedTarget "Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen within the interior space of cortical radial arteries (interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033951 ; owl:annotatedTarget "Thrombi containing fibrous tissue and capillary-like vascular channels within the interior space of cortical radial arteries (interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47909 ; owl:annotatedTarget "3-oxo-Delta(4) steroids" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033951 ; owl:annotatedTarget "Organised thrombi within interlobular arterial lumen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033952 ; owl:annotatedTarget "Abnormal structural characteristics of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033953 ; owl:annotatedTarget "Enlargement of endothelial cells of the cortical radial arteries (also known as the interlobular arteries) of the kidney because of cytoplasmic swelling." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033954 ; owl:annotatedTarget "Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033956 ; owl:annotatedTarget "A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of cortical radial arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033958 ; owl:annotatedTarget "A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often macrophages, with a vacuolated appearance in the lumen of cortical radial artery (also known as the interlobular artery) of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033959 ; owl:annotatedTarget "Thickening of the intima of the cortical radial artery (also known as the interlobular artery) of the kidney characterized by fibrosis and/or duplication of the elastic lamina." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033960 ; owl:annotatedTarget "Accumulation of edematous extracellular matrix in the intima of the cortical radial artery (also known as the interlobular artery) of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033960 ; owl:annotatedTarget "Intimal mucoid oedema within interlobular arterial intima/media" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033961 ; owl:annotatedTarget "Myointimal hyperplasia of the inner and middle layer of the cortical radial artery (also known as the interlobular artery) of the kidney, arranged in multiple concentric layers." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_47909 ; owl:annotatedTarget "a 3-oxo-Delta(4)-steroid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033962 ; owl:annotatedTarget "A type of cortical radial artery medial/intimal arteriitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033964 ; owl:annotatedTarget "Thickening of the intima with fibrosis and/or duplication of the elastic lamina in interlobular veins of the kidney." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0033965 ; owl:annotatedTarget "Intimal mucoid oedema within interlobular veins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033966 ; owl:annotatedTarget "Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular veins of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033967 ; owl:annotatedTarget "Inflammation of the interlobular veins of the kidney which may affect only the intima or may be transmural." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033968 ; owl:annotatedTarget "A type of interlobular vein intima/media venulitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033969 ; owl:annotatedTarget "Cell death (necrosis) in the inner or middle layer of the interlobular vein of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033970 ; owl:annotatedTarget "A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033971 ; owl:annotatedTarget "A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033972 ; owl:annotatedTarget "Atrophy (wasting, decreased thickness) of the medial layer pf the interlobular veins of the kidney." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48154 ; owl:annotatedTarget "Schwefeloxide" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033973 ; owl:annotatedTarget "Increased thickness of middle layer of the interlobular veins of the kidney." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033974 ; owl:annotatedTarget "Myointimal hyperplasia of the inner and middle layer of the interlobular veins of the kidney, arranged in multiple concentric layers." . [] oboInOwl:hasDbXref "PMID:33568816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033975 ; owl:annotatedTarget "Absence of the fingernail of the index (second) finger." . [] oboInOwl:hasDbXref "PMID:20724029" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033976 ; owl:annotatedTarget "The presence of an extra nail on the palmar (volar, ventral) surface of the finger." . [] oboInOwl:hasDbXref "PMID:28436373" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033977 ; owl:annotatedTarget "Absent talus owing to a congenital defect." . [] oboInOwl:hasDbXref "PMID:33407268" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033978 ; owl:annotatedTarget "Diminished activity of the enzyme beta-hexosaminidase in the blood circulation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033979 ; owl:annotatedTarget "Excessive anterior displacement of the tracheal and/or bronchial membranous wall." . [] oboInOwl:hasDbXref "PMID:29095389" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033980 ; owl:annotatedTarget "Recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness." . [] oboInOwl:hasDbXref "PMID:32938213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033982 ; owl:annotatedTarget "A separation (dissection) of the layers of the celiac artery wall." . [] oboInOwl:hasDbXref "PMID:33252156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033985 ; owl:annotatedTarget "Increased length of the neck of the femur." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48154 ; owl:annotatedTarget "oxides of sulfur" . [] oboInOwl:hasDbXref "PMID:26855770" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033986 ; owl:annotatedTarget "The presence of an increased number of twists and turns of lymphatic vessels." . [] oboInOwl:hasDbXref "PMID:33442358" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033987 ; owl:annotatedTarget "A rare, endocrine active tumor that causes severe renal phosphate wasting, which in turn can lead to critical osteomalacia. Phosphaturic mesenchymal tumors (PMTs) are typically small and mostly benign tumors producing fibroblast growth factor 23 (FGF-23). FGF-23 lowers the expression of sodium/phosphate cotransporters, which are the primary transport proteins responsible for phosphate reabsorption in the kidneys. The paraneoplastic overproduction of FGF-23 lowers reabsorption of phosphate and causes severe paraneoplastic renal phosphate wasting and hypophosphatemia. FGF-23 also affects vitamin D levels by lowering 25-hydroxyvitamin D 1-alpha-hydroxylase in the proximal renal tubules and by increasing the expression of vitamin D 24-hydroxylase, a mitochondrial enzyme responsible for inactivating vitamin D metabolites." . [] oboInOwl:hasDbXref , "PMID:10867785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033988 ; owl:annotatedTarget "An infarct located in the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe that can only be observed microscopically." . [] oboInOwl:hasDbXref , "PMID:10867785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033989 ; owl:annotatedTarget "An infarct located in the structure of the cerebrum involved with memory storage and spatial navigation that can only be observed microscopically." . [] oboInOwl:hasDbXref "PMID:32028503", "PMID:33880195" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033991 ; owl:annotatedTarget "Vasa previa occurs when the membranes that contain the umbilical cord traverse the membranes overlying the internal os of the cervix. There is a high risk of fetal mortality if not identified perinatally." . [] oboInOwl:hasDbXref "PMID:21382903" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033992 ; owl:annotatedTarget "Inability of the heart to increase its rate commensurate with increased activity or demand." . [] oboInOwl:hasDbXref "PMID:21960712", "PMID:30366550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033993 ; owl:annotatedTarget "An inflammation of brain parenchyma due to infection with a virus. Viral encephalitis can occur as a rare complication of common infections (eg, herpes virus infections) or can occur as a characteristic presentation of rare viruses (eg, rabies virus infection). Encephalitis may be the only neurologic manifestation of infection, or may occur in association with meningitis, myelitis, radiculitis, or neuritis. Viral encephalitis is associated with neurological dysfunction." . [] oboInOwl:hasDbXref "PMID:26830108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033995 ; owl:annotatedTarget "The presence of vacuoles bearing centripetal microvilli in small gut villus enterocytes." . [] oboInOwl:hasDbXref "PMID:26830108" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033996 ; owl:annotatedTarget "The presenceaccumulationof periodic acid-Schiff (PAS) granules in the subapical region of small intenstinal microvilli, appearing as different kinds of vesicular/tubular structures." . [] oboInOwl:hasDbXref "PMID:32514796" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033997 ; owl:annotatedTarget "Formation of vacuoles, i.e., membrane-bound organelles, in the portion of the cytoplasm near the nucleus within myocytes of the heart." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48154 ; owl:annotatedTarget "sulfur oxides" . [] oboInOwl:hasDbXref "PMID:17853480" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033998 ; owl:annotatedTarget "A developmental defect of pulmonary lobation characterized by the presence of only one lobe of the right lung, which normally has three lobes." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0033999 ; owl:annotatedTarget "Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034000 ; owl:annotatedTarget "Tracheal hemorrhage is a focal bleeding within the trachea. It be diagnosed by tracheobronchoscopy." . [] oboInOwl:hasDbXref , "PMID:34032207", "PMID:34032209" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034001 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against complement factor H." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034001 ; owl:annotatedTarget "CFH autoantibodies" . [] oboInOwl:hasDbXref , "PMID:34169209", "PMID:34277215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034002 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the phospholipase A2 receptor." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034002 ; owl:annotatedTarget "Anti-PLA2R antibody positivity" . [] oboInOwl:hasDbXref "PMID:33790036", "PMID:34055592" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034004 ; owl:annotatedTarget "Misperception of existing odor, that is, distorted or altered olfactory perception in the presence of known stimuli." . [] oboInOwl:hasDbXref "PMID:26306627" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034006 ; owl:annotatedTarget "A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation." . [] oboInOwl:hasDbXref "PMID:34161705" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034008 ; owl:annotatedTarget "Wasting (atrophy) of the optic chiasm." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:11093705" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Beilstein:1735878" . [] oboInOwl:hasDbXref "PMID:25247089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034009 ; owl:annotatedTarget "Overgrowth of fat in the perivesical and perirectal area." . [] oboInOwl:hasDbXref "PMID:10891439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034010 ; owl:annotatedTarget "Increased numbers of megakryocyte precursors (megakaryocyte colony forming units) in the bone marrow." . [] oboInOwl:hasDbXref "PMID:8957699" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034011 ; owl:annotatedTarget "A reduced proportion of sperm that move in a straight line or large circles; alternatively, an increaed proportion of sperm that move in tight circles or in some other non-linear fashion." . [] oboInOwl:hasDbXref "PMID:24664640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034012 ; owl:annotatedTarget "Decreased sweating on the palms and soles." . [] oboInOwl:hasDbXref , "PMID:28067000", "PMID:30104143", "PMID:31285412" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034013 ; owl:annotatedTarget "A type of pericallosal lipoma that is thin and curves around the posterior end of the splenium of the corpus callosum." . [] oboInOwl:hasDbXref , "PMID:1885799", "PMID:31587959" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034014 ; owl:annotatedTarget "A type of pericallosal lipoma with a rounded or lobular appearance and a diameter that is usually above 2 cm. They are anteriorly situated and are associated with extensive callosal and often fronto-facial anomalies. A tubulonodular pericallosal lipoma can extend into the choroid plexus or lateral ventricles." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034015 ; owl:annotatedTarget "Thick-walled abnormal gas-filled interstitial nodule within a lung." . [] oboInOwl:hasDbXref "PMID:29985463" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034016 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen (HLA)." . [] oboInOwl:hasDbXref "PMID:571908" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034026 ; owl:annotatedTarget "An increased concentration of saccharopine in the blood circulation. L-saccharopine is the N(6)-(1,3-dicarboxypropan-1-yl) derivative of L-lysine." . [] oboInOwl:hasDbXref "PMID:30573525", "PMID:32768327", "PMID:33996359" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034028 ; owl:annotatedTarget "Presence of saccharopine in the urine." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "CAS:149-32-6" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034030 ; owl:annotatedTarget "Bluish discoloration of the lips." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034030 ; owl:annotatedTarget "Bluish lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034031 ; owl:annotatedTarget "Bluish discoloration of one or more regions of the face." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034031 ; owl:annotatedTarget "Bluish face" . [] oboInOwl:hasDbXref , "PMID:32644593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034032 ; owl:annotatedTarget "Generalized bluish discoloration of the body and the visible mucous membranes, which occurs due to inadequate oxygenation secondary to conditions that lead to an increase in deoxygenated hemoglobin or presence of abnormal hemoglobin." . [] oboInOwl:hasDbXref , "PMID:32644593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034033 ; owl:annotatedTarget "Bluish discoloration of the distal extremities (hands, fingertips, toes), and can sometimes involve circumoral and periorbital areas. Mucous membranes are generally not involved." . [] oboInOwl:hasDbXref , "PMID:32644593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034034 ; owl:annotatedTarget "Differential degree of bluish discoloration between the upper and lower extremities." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034035 ; owl:annotatedTarget "Fluid exuded from the posterior wall of the pharynx." . [] oboInOwl:hasDbXref , "PMID:33972057" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034036 ; owl:annotatedTarget "Inflammatory chilblain-like nodules on the feet and/or toes." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034036 ; owl:annotatedTarget "COVID toe" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "CAS:7541-59-5" . [] oboInOwl:hasDbXref , "PMID:33972057" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034037 ; owl:annotatedTarget "Inflammatory chilblain-like nodules on the hands and/or fingers." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034037 ; owl:annotatedTarget "COVID finger" . [] oboInOwl:hasSynonymType hp:layperson, hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034037 ; owl:annotatedTarget "COVID fingers" . [] oboInOwl:hasDbXref , "PMID:32539537" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034038 ; owl:annotatedTarget "Abnormally low blood oxygen level without the presence of dyspnea." . [] oboInOwl:hasDbXref "PMID:24826218" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034039 ; owl:annotatedTarget "Two consecutive premature ventricular contractions (PVCs) with no intervening normal beats." . [] oboInOwl:hasDbXref "PMID:25173208", "PMID:30567276" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034040 ; owl:annotatedTarget "Bidirectional ventricular tachycardia (BDVT) is a regular ventricular tachyarrhythmia (VT) with two different QRS morphologies alternating at a rate typically between 140 and 180 bpm." . [] oboInOwl:hasDbXref "PMID:32063472" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034041 ; owl:annotatedTarget "Ventricular ectopics, also known as ventricular extrasystoles, premature ventricular contractions or complexes (PVC) and ventricular premature depolarisations (VPD) are beats arising from within the ventricles. When they occur in groupings such as bigeminy, trigeminy, couplets and triplets they are referred to as ventricular ectopy." . [] oboInOwl:hasDbXref "PMID:9109432" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034043 ; owl:annotatedTarget "Elevated amount of bile acids in the feces." . [] oboInOwl:hasDbXref "PMID:28744080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034044 ; owl:annotatedTarget "Spurs at the medial and lateral acetabular margin and in the center of the acetabulum gives rise to shape resembling a three-pronged spear known as trident." . [] oboInOwl:hasDbXref "PMID:22938878", "PMID:32529201" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034045 ; owl:annotatedTarget "Normal muscle fibers are polygonal-shaped in cross section, are multinucleated, and have minimal amounts of endomysial connective tissue. In contrast, angulated (also known as angular) muscle fibers have long and narrow vertices (corners) with sharp edges and a pointed tip." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Reaxys:1735878" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034045 ; owl:annotatedTarget "Angular muscle fibres" . [] oboInOwl:hasDbXref "PMID:21932319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034046 ; owl:annotatedTarget "Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to the mandible." . [] oboInOwl:hasDbXref "PMID:21932319" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034047 ; owl:annotatedTarget "Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to a rib." . [] oboInOwl:hasDbXref "PMID:24838973" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034049 ; owl:annotatedTarget "An increased amount of prostaglandin E2 in the urine." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034049 ; owl:annotatedTarget "Elevated urinary PGE2 level" . [] oboInOwl:hasDbXref "PMID:28700713" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034050 ; owl:annotatedTarget "An increased amount of prostaglandin E2 metabolite (PGE-M) in the urine." . [] oboInOwl:hasDbXref "PMID:32395406" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034051 ; owl:annotatedTarget "Underdevelopment of the frontal part (anterior crus or anterior limb) of the internal capsule." . [] oboInOwl:hasDbXref "PMID:17898206", "PMID:33642486" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034054 ; owl:annotatedTarget "Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles." . [] oboInOwl:hasDbXref , "PMID:9030872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034055 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), which is encoded by CYP11A1 cytochrome P450 family 11 subfamily A member 1 (Gene ID:1583)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034055 ; owl:annotatedTarget "Anti-P450scc" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "butane-1,2,3,4-tetrol" . [] oboInOwl:hasDbXref "PMID:28420947", "PMID:30828114" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0034056 ; owl:annotatedTarget "Calprotectin is a calcium- and zinc-binding protein of the S-100 protein family which is mainly found within neutrophils and throughout the human body. The presence of calprotectin in faeces is a consequence of neutrophil migration into the gastrointestinal tissue due to an inflammatory process. Faecal calprotectin concentrations demonstrate good correlation with intestinal inflammation and faecal calprotectin is used as a biomarker in gastrointestinal disorders." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034058 ; owl:annotatedTarget "Structural foetal anomaly" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034059 ; owl:annotatedTarget "Functional foetal anomaly" . [] oboInOwl:hasDbXref "PMID:29298156" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034060 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by eating fava beans." . [] oboInOwl:hasDbXref , "PMID:9030872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034061 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against steroid 17alpha-hydroxylase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034061 ; owl:annotatedTarget "Anti-P450C17" . [] oboInOwl:hasDbXref , "PMID:17143785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034062 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against insulin." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034062 ; owl:annotatedTarget "IAA positivity" . [] oboInOwl:hasDbXref , "PMID:9693976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034063 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against tyrosine phosphatase IA-2." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034063 ; owl:annotatedTarget "Anti-IA2 antibody positivity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "1,2,3,4-tetrahydroxybutane" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034063 ; owl:annotatedTarget "Anti-IA2A" . [] oboInOwl:hasDbXref , "PMID:34249010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034064 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against salivary protein." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034064 ; owl:annotatedTarget "Anti-SP1 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:32946793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034065 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against zinc transporter 8." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034065 ; owl:annotatedTarget "Anti ZnT8 autoantibodies" . [] oboInOwl:hasDbXref , "PMID:34249010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034066 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase VI." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034066 ; owl:annotatedTarget "Anti-CA6 antibody positivity" . [] oboInOwl:hasDbXref "PMID:18461349", "PMID:7529919" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034067 ; owl:annotatedTarget "Formation of lumps of tonofilaments, which are bundles of keratin filaments. In some but not all epithelia, keratin filaments are conspicuously bundled as tonofilaments. Inside the cell they braid the nucleus, span through the cytoplasm and are attached to the cytoplasmic plaques of the typical epithelial cell-cell junctions, the desmosomes." . [] oboInOwl:hasDbXref , "PMID:30075546" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034068 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against plasminogen binding peptide." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034068 ; owl:annotatedTarget "Anti-PBP antibody positivity" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Erythrite" . [] oboInOwl:hasDbXref , "PMID:34249010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034069 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against parotid secretory protein." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034069 ; owl:annotatedTarget "Anti-PSP antibody positivity" . [] oboInOwl:hasDbXref , "PMID:24051695", "PMID:33744411" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034070 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against enterocytes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034070 ; owl:annotatedTarget "AEA" . [] oboInOwl:hasDbXref , "PMID:22707647", "PMID:9030872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034071 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against 21-hydroxylase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034071 ; owl:annotatedTarget "Anti-P450c21" . [] oboInOwl:hasDbXref "PMID:21472065" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034072 ; owl:annotatedTarget "Any deviation from the normal appearing echogenicity of the fetal bone. Echogenicity refers to the ability of tissue to reflect ultrasound waves back toward the transducer and produce an echo. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. The higher the echogenicity of tissues, the brighter they appear on ultrasound imaging." . [] oboInOwl:hasDbXref "PMID:24091809", "PMID:28548288" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034074 ; owl:annotatedTarget "An abnormally elevated echogenicity of fetal long bones in a prenatal sonographic investigation. This finding is due to hypermineralization." . [] oboInOwl:hasDbXref "PMID:16333315" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034075 ; owl:annotatedTarget "Reduced circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100." . [] oboInOwl:hasDbXref , "PMID:14645862", "PMID:25815344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034076 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ribosome Po." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Erythrol" . [] oboInOwl:hasDbXref , "PMID:25815344" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034077 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against C1q." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034077 ; owl:annotatedTarget "Anti-C1q antibody positivity" . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034078 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-A." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034078 ; owl:annotatedTarget "Anti-CENP-A antibody positivity" . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034079 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-B." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034079 ; owl:annotatedTarget "Anti-CENP-B antibody positivity" . [] oboInOwl:hasDbXref , "PMID:34207757" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034080 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U3 RNP." . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034081 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Th/To." . [] oboInOwl:hasDbXref , "PMID:29369808" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034082 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against bicaudal D2." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034082 ; owl:annotatedTarget "Anti-BICD2 antibody positivity" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Phycite" . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034083 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Nor90." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034083 ; owl:annotatedTarget "Anti-Nor90 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:22796282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034084 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl ethanolamine." . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034085 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl100." . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034086 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl75." . [] oboInOwl:hasDbXref , "PMID:19565553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034087 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U11/U12 RNP." . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034088 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ku." . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034089 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against B23." . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034090 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against RuvBL1/2." . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034091 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against platelet derived growth factor receptor." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48299 ; owl:annotatedTarget "Phycitol" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034091 ; owl:annotatedTarget "Anti-PDGFR antibody positivity" . [] oboInOwl:hasDbXref , "PMID:30316987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034092 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cyclic citrullinated peptide." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034092 ; owl:annotatedTarget "Anti-CCP antibody positivity" . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034093 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro52/TRIM21." . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034094 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin receptor type-1." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034094 ; owl:annotatedTarget "Anti-AT1R antibody positivity" . [] oboInOwl:hasDbXref , "PMID:28749191" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034095 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endothelin-1 type A receptor." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034095 ; owl:annotatedTarget "Anti-ETAR antibody positivity" . [] oboInOwl:hasDbXref , "PMID:30868842" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034096 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidic acid." . [] oboInOwl:hasDbXref , "PMID:31354742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034097 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl choline." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:11164910" . [] oboInOwl:hasDbXref , "PMID:26563139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034098 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl glycerol." . [] oboInOwl:hasDbXref , "PMID:31354742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034099 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl inositol." . [] oboInOwl:hasDbXref , "PMID:26563139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034100 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl serine." . [] oboInOwl:hasDbXref , "PMID:33464429" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034101 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against annexin-V." . [] oboInOwl:hasDbXref , "PMID:31354742" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034102 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against sphingolipids." . [] oboInOwl:hasDbXref , "PMID:32460711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034103 ; owl:annotatedTarget "Ganglioside-monosialic acid (GM1) is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury" . [] oboInOwl:hasDbXref , "PMID:32091008" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034104 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neutrophil elastase." . [] oboInOwl:hasDbXref , "PMID:33876712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034105 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transcription intermediary factor-1gamma." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034105 ; owl:annotatedTarget "Anti-TIF-1gamma antibody positivity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034105 ; owl:annotatedTarget "Anti-TIF1-gamma antibody positivity" . [] oboInOwl:hasDbXref , "PMID:33876712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034106 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Su antigen/argonaute 2." . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034107 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against p53." . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034108 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Y-box protein-1." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034108 ; owl:annotatedTarget "Anti-YB 1 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:14598044", "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034109 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GW182." . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034110 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ge-1." . [] oboInOwl:hasDbXref , "PMID:29554146", "PMID:32286240" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034111 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against MIT3." . [] oboInOwl:hasDbXref , "PMID:32460711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034112 ; owl:annotatedTarget "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GM1." . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034113 ; owl:annotatedTarget "The presence of type I liver-kidney microsomal autoantibodies (immunoglobulins) in the blood circulation." . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034114 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against hexokinase-1." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "Beilstein:1719752" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034114 ; owl:annotatedTarget "Anti-HK-1 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:29554146" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034115 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Kelch like protein 12." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034115 ; owl:annotatedTarget "Anti-KLHL-12 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:32459722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034116 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against thyrotropin receptor antibody." . [] oboInOwl:hasDbXref , "PMID:33910447" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034117 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin-converting enzyme 2." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034117 ; owl:annotatedTarget "Anti-ACE2 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:34759020" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034118 ; owl:annotatedTarget "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GM1." . [] oboInOwl:hasDbXref , "PMID:24829594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034119 ; owl:annotatedTarget "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a." . [] oboInOwl:hasDbXref , "PMID:31522790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034120 ; owl:annotatedTarget "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a." . [] oboInOwl:hasDbXref , "PMID:24829594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034123 ; owl:annotatedTarget "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "Beilstein:5725952" . [] oboInOwl:hasDbXref , "PMID:31837178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034124 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." . [] oboInOwl:hasDbXref , "PMID:31837178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034125 ; owl:annotatedTarget "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." . [] oboInOwl:hasDbXref , "PMID:31837178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034126 ; owl:annotatedTarget "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside." . [] oboInOwl:hasDbXref , "PMID:24829594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034127 ; owl:annotatedTarget "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b." . [] oboInOwl:hasDbXref , "PMID:24829594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034129 ; owl:annotatedTarget "The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside." . [] oboInOwl:hasDbXref , "PMID:24829594" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034130 ; owl:annotatedTarget "The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside." . [] oboInOwl:hasDbXref , "PMID:17785314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034131 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1b ganglioside." . [] oboInOwl:hasDbXref , "PMID:31522790" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034132 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM2." . [] oboInOwl:hasDbXref , "PMID:34174799" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034133 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM3." . [] oboInOwl:hasDbXref , "PMID:17785314" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034134 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM4." . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "CAS:2418-52-2" . [] oboInOwl:hasDbXref , "PMID:32266541", "PMID:34728497" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034135 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF155." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034135 ; owl:annotatedTarget "Anti-NF155 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:32266541", "PMID:33723708" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034136 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF186." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034136 ; owl:annotatedTarget "Anti-NF186 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:32266541", "PMID:34675937" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034137 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CNTN1." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034137 ; owl:annotatedTarget "Anti-CNTN1 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:32266541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034138 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-contactin-associated protein 1." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034138 ; owl:annotatedTarget "Anti-CASPR1 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:33343724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034139 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034139 ; owl:annotatedTarget "Anti-SAE antibody positivity" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "CAS:7493-90-5" . [] oboInOwl:hasDbXref , "PMID:22884621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034140 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 1." . [] oboInOwl:hasDbXref , "PMID:22884621" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034141 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 2." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034141 ; owl:annotatedTarget "Anti-SAE 2 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:33343724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034142 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NXP-2." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034142 ; owl:annotatedTarget "Anti-MJ/NXP-2 antibody positivity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034142 ; owl:annotatedTarget "Anti-NXP-2 antibody positivity" . [] oboInOwl:hasDbXref , "PMID:22732951", "PMID:33343724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034143 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against threonyl-tRNA synthetase." . [] oboInOwl:hasDbXref , "PMID:30915082", "PMID:32083547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034144 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro60." . [] oboInOwl:hasDbXref , "PMID:33343724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034145 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against alanyl-tRNA synthetase." . [] oboInOwl:hasDbXref , "PMID:27212602" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034146 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycyl tRNA-synthetase." . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "Gmelin:1782960" . [] oboInOwl:hasDbXref "PMID:23573256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034147 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a tRNA synthetase enzyme." . [] oboInOwl:hasDbXref , "PMID:33343724" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034148 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against isoleucyl tRNA-synthetase." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034148 ; owl:annotatedTarget "Anti-OJ antibody positivity" . [] oboInOwl:hasDbXref , "PMID:31665469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034149 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phenylalanyl tRNA synthetase." . [] oboInOwl:hasDbXref , "PMID:32933078" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034150 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against tyrosyl-tRNA synthetase." . [] oboInOwl:hasDbXref , "PMID:32933078" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034151 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against asparaginyl-tRNA synthetase." . [] oboInOwl:hasDbXref , , "PMID:15804708", "PMID:26210509" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034152 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase." . [] oboInOwl:hasDbXref , "PMID:32933078" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034153 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cytosolic-5-nucleotidase-1A (cN1A)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034153 ; owl:annotatedTarget "Anti-cN1A antibody positivity" . [] oboInOwl:hasDbXref , "PMID:24557777" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034154 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ki." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:1596913" . [] oboInOwl:hasDbXref "PMID:32286240", "PMID:33789734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034155 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against sp100. Autoantibodies causing the MND pattern are directed against sp100, sp140, promyelocytic leukemia nuclear body proteins (PML) or ubiquitin-like modifier (SUMO) proteins, while in the punctate nuclear envelope pattern, the target antigens are gp210, nucleoporin-62 or laminin B receptor proteins." . [] oboInOwl:hasDbXref , "PMID:33957795", "PMID:34218350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034156 ; owl:annotatedTarget "Presence of IgG antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034156 ; owl:annotatedTarget "Anti-beta2GPI IgG antibody positivity" . [] oboInOwl:hasDbXref , "PMID:33957795", "PMID:34218350" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034157 ; owl:annotatedTarget "Presence of IgM antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034157 ; owl:annotatedTarget "Anti-beta2GPI IgM antibody positivity" . [] oboInOwl:hasDbXref "PMID:22966073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034158 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against the tyrosine phossphatase region of islet antigen 2A (this region is a specific part of IA-2). Usually IA-2A are measured using the intracellular portion of IA-2 (IA-2ic) made up of the protein tyrosine phosphatase (PTP) and juxtamembrane (JM) regions." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034158 ; owl:annotatedTarget "Anti-PTPA antibody positivity" . [] oboInOwl:hasDbXref "PMID:26251641", "PMID:31194327" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034180 ; owl:annotatedTarget "Abnormal joined appearance of the caudate and putamen with an absence of the anterior limb of the internal capsule." . [] oboInOwl:hasDbXref "PMID:23573097" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034182 ; owl:annotatedTarget "Anatomically the liver is divided into right and left lobes based on the attachment of its peritoneal ligaments. This term refers to a developmental anomaly characterzied by the underdevelopment of one of the lobes of the liver. This is a rare and usually asymptomatic anomaly that can be detected incidentally on cross sectional imaging with computed tomography or magnetic resonance imaging." . [] oboInOwl:hasDbXref , "PMID:27188686", "PMID:32821558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034183 ; owl:annotatedTarget "Spastic weakness found in both lower extremities and one upper extremity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:16748290" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034184 ; owl:annotatedTarget "Increased circulating IGFALS contration" . [] oboInOwl:hasDbXref "PMID:25535458" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034185 ; owl:annotatedTarget "A type of mild median cleft lip in which the central tubercle of the upper lip is replaced by a mucosal cleft in the midline." . [] oboInOwl:hasDbXref "PMID:29309446" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034186 ; owl:annotatedTarget "Patella alta is a patella that rides abnormally high in relation to the femur, the femoral trochlea, or the tibia, with decreased bony stability requiring increased knee flexion angles to engage the trochlea." . [] oboInOwl:hasDbXref "PMID:19232556" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034187 ; owl:annotatedTarget "A developmental defect in a the clavicule leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or false joint)." . [] oboInOwl:hasDbXref "PMID:12432114" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034188 ; owl:annotatedTarget "Position of the liver across the middle of the body instead of being in its normal position to the right of the stomach." . [] oboInOwl:hasDbXref , "PMID:10874533", "PMID:26293122", "PMID:3018097", "PMID:30224035" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034189 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid-stimulating hormone." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034189 ; owl:annotatedTarget "Anti-TSH receptor antibody positivity" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034189 ; owl:annotatedTarget "TRAbs" . [] oboInOwl:hasDbXref , "PMID:28191060" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034191 ; owl:annotatedTarget "Increased peak systolic velocity of the fetal middle cerebral artery (MCA) as evaluated by Doppler ultrasound." . [] oboInOwl:hasDbXref "PMID:29770793" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034192 ; owl:annotatedTarget "Pulmonary embolism is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:16901854" . [] oboInOwl:hasDbXref "PMID:10765517", "PMID:21335936", "PMID:24871613", "PMID:24931552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034196 ; owl:annotatedTarget "A developmental defect characterized by lack of formation of the ductus venosus (a shunt that allows oxygenated blood in the umbilical vein to bypass the liver in the fetal circulation)." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034199 ; owl:annotatedTarget "Early foetal onset" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:11534772" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:17577890" . [] oboInOwl:hasDbXref "PMID:30844193" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034204 ; owl:annotatedTarget "Decreased concentration of C1-esterase inhibitor (C1INH) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:33294089" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034205 ; owl:annotatedTarget "Iniencephaly is a rare neural tube defect involving dysmorphic spine and abnormal fusion of the portion of the occipital skull with the back. It results in extreme fixed head retroflexion." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034206 ; owl:annotatedTarget "Abnormal fetal CNS morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034206 ; owl:annotatedTarget "Abnormal foetal CNS morphology" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034209 ; owl:annotatedTarget "Grade I foetal intracranial haemorrhage" . [] oboInOwl:hasDbXref "PMID:16082722", "PMID:27734711" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034210 ; owl:annotatedTarget "A type of fetal intracranial hemorrhage with bleeding into the ventricular system of the brain." . [] oboInOwl:hasDbXref "PMID:16082722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034211 ; owl:annotatedTarget "A type of fetal intracranial hemorrhage with bleeding into the parenchyma (tissue) of the brain." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:17979222" . [] oboInOwl:hasDbXref "PMID:16082722" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034214 ; owl:annotatedTarget "A type of fetal intraventricular hemorrhage characterized by clear hemorrhage spillover to the ventricles filling less than 50% of the lateral ventricle and without ventriculomegaly of greater than 15 mm in the transverse diameter of the lateral ventricular atrium." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034214 ; owl:annotatedTarget "Grade II foetal intracranial haemorrhage" . [] oboInOwl:hasDbXref "PMID:12795563", "PMID:26426778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034215 ; owl:annotatedTarget "A type of fetal intracranial hemorrhage that occurs in the hemisphere of the cerebellum." . [] oboInOwl:hasDbXref "PMID:26426778" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034216 ; owl:annotatedTarget "A type of fetal intracranial hemorrhage that occurs in the vermis of the cerebellum." . [] oboInOwl:hasDbXref "PMID:8915088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034217 ; owl:annotatedTarget "Inability to visualize the fetal bladder on targeted prenatal sonography examination. The fetal bladder can be visualized with sonography as a midline, fluid-filled structure in the pelvis as early as 10-12 weeks of gestation. The normal fetus voids at least once an hour but never completely empties the urinary bladder. The fetal bladdder should be consistently imaged after 13 weeks of gestation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034218 ; owl:annotatedTarget "Grade III foetal intracranial haemorrhage" . [] oboInOwl:hasDbXref "PMID:12905503" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034219 ; owl:annotatedTarget "A type of fetal intraventricular hemorrhage that additionally includes hemorrhage in a large part of the periventricular parenchyma." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034219 ; owl:annotatedTarget "Grade IV foetal intracranial haemorrhage" . [] oboInOwl:hasDbXref , "PMID:19098178" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034220 ; owl:annotatedTarget "Expansion of the temporal lobes of the brain along all axes, including rostrocaudal, superoinferior, and mediolateral, resulting in a globular appearance of the brain." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:18863753" . [] oboInOwl:hasDbXref , "PMID:24585534" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034222 ; owl:annotatedTarget "A developmental defect of the temporal lobe of the cerebral cortex that is characterized by prominent sulcations and radially directed gyrations." . [] oboInOwl:hasDbXref "PMID:32746120" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034223 ; owl:annotatedTarget "Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth." . [] oboInOwl:hasDbXref "PMID:19797010" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0034224 ; owl:annotatedTarget "Abnormal umbilical artery Doppler velocimetry is correlated with a pathologic lesion of the placenta characterized by obliteration of arterioles in the tertiary stem villi; the umbilical artery flow velocity waveform is primarily determined by placental villous vascular architecture. The increased placental vascular resistance is reflected as a decreased diastolic phase of the umbilical artery waveform" . [] oboInOwl:hasDbXref "PMID:19797010" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034225 ; owl:annotatedTarget "An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:22735334" . [] oboInOwl:hasDbXref , "PMID:23408600", "PMID:31173381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034226 ; owl:annotatedTarget "Characteristic appearance of the chest and abdomen in the sagittal view on prenatal ultrasound when the chest is small and the abdomen protruding." . [] oboInOwl:hasDbXref "PMID:27860551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034227 ; owl:annotatedTarget "A type of aortic arch hypoplasia whereby the isthmus (arch between the left subclavian and insertion of the patent ductus arteriosus/ligamentum arteriosum) has a diameter of less than 40% of the diameter of the ascending aorta." . [] oboInOwl:hasDbXref "PMID:27860551" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034228 ; owl:annotatedTarget "A type of aortic arch hypoplasia whereby the proximal aortic arch (arch proximal to the origin of the left subclavian artery) has a diameter of less than 60% of the diameter of the ascending aorta." . [] oboInOwl:hasDbXref "PMID:29446682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034230 ; owl:annotatedTarget "A type of cross fused renal ectopia characterized by fusion between the upper pole of the cross-fused ectopic kidney (located more inferiorly relative to the other kidney) and the lower pole of the other orthotopic kidney (located in a more superior position)." . [] oboInOwl:hasDbXref "PMID:23599575", "PMID:29446682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034231 ; owl:annotatedTarget "A type of cross fused renal ectopia where the normal side kidney is present superiorly and the direction of pelvic is medial, the kidney which crosses positioned inferiorly with direction of pelvic toward the lateral side. As kidneys fuse after complete rotation on the vertical axis, both renal pelves lie in correct orientation." . [] oboInOwl:hasDbXref "PMID:29446682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034232 ; owl:annotatedTarget "A type of cross fused renal ectopia where fusion occurs over a wide margin, both renal pelves anteriorly directed and placed more inferiorly." . [] oboInOwl:hasDbXref "PMID:29446682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034234 ; owl:annotatedTarget "A type of cross fused renal ectopia in which the crossed kidney lies inferiorly and transversely, fused with the lower pole of the normal kidney." . [] oboInOwl:hasDbXref "PMID:29446682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034235 ; owl:annotatedTarget "A type of cross fused renal ectopia in which the ectopic kidney lies superiorly and its lower pole fuses with the upper pole of the normal kidney. The renal pelvis of both kidneys lies anteriorly." . [] oboInOwl:hasDbXref , "PMID:21301866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034236 ; owl:annotatedTarget "Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034236 ; owl:annotatedTarget "AOP" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:24643482" . [] oboInOwl:hasDbXref "PMID:23456749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034237 ; owl:annotatedTarget "A type of neural tube defect that is not covered by skin." . [] oboInOwl:hasDbXref "PMID:23456749" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034238 ; owl:annotatedTarget "A type of neural tube defect that is covered by skin." . [] oboInOwl:hasDbXref "PMID:30725656" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034239 ; owl:annotatedTarget "The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output." . [] oboInOwl:hasDbXref "PMID:30422714" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034240 ; owl:annotatedTarget "An abnormal growth (lump) of tissue in the neck region of a fetus. Masses may be simple cystic,, cystic with a few simple septations (fewer than three septations and less than 3-mm thick), cystic with multiple or thick septations (greater than three septations or septations 3-mm-thick or more), a mass that is than is less than 50% solid, and a mass that is 50% solid or more." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034241 ; owl:annotatedTarget "Death before birth" . [] oboInOwl:hasDbXref "PMID:15888614" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034244 ; owl:annotatedTarget "At US examination from the second trimester onward, the fetal stomach appears as a uniformly anechoic, sharply circumscribed round structure in the left upper quadrant. However, debris is commonly visualized in the stomach, forming a pseudomass." . [] oboInOwl:hasDbXref "PMID:24767653" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034246 ; owl:annotatedTarget "An abnormal growth (lump) of tissue that projects from the fetal scalp." . [] oboInOwl:hasDbXref "PMID:35136187" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034247 ; owl:annotatedTarget "An obstruction in the ureter leading to bladder outlet obstruction. Special criteria are used for lower urinary tract obstruction (LUTO) in the fetus. Prenatal LUTO has classically been suspected on the basis of three ultrasonographic findings: megacystis, dilated posterior urethra (known as the keyhole sign) and hydronephrosis." . [] oboInOwl:hasDbXref "PMID:27433255" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034248 ; owl:annotatedTarget "Increased echogenicity (increased brightness in the gray-scale sonography image) of the lens of a fetus." . [] oboInOwl:hasDbXref "PMID:25814066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034249 ; owl:annotatedTarget "An unusually severe infection by an influenza virus." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:25108762" . [] oboInOwl:hasDbXref "PMID:16507941", "PMID:9880279" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034250 ; owl:annotatedTarget "Nuchal edema is considered present in a fetus at gestational week 14 or more if in the midsagittal plane of the neck, there is subcutaneous edema that produces a characteristic tremor on ballotment of the fetal head. This constitutes the severe end of the spectrum of increased nuchal fold thickness, which is defined as soft-tissue thickening of 6 mm or more, seen in the suboccipitobregmatic view of the fetal head. Nuchal edema may be confined to the neck or it may be generalized, as part of hydrops fetalis." . [] oboInOwl:hasDbXref "PMID:30480980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034251 ; owl:annotatedTarget "An anomaly of the corneal reflex that normally induces involuntary blinking of the eyelids following contact of the cornea." . [] oboInOwl:hasDbXref "PMID:30480980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034252 ; owl:annotatedTarget "Absence of the corneal blinking reflex, which normally induces involuntary blinking of the eyelids following contact of the cornea. The corneal blink reflex is caused by a loop between the trigeminal sensory nerves and the facial motor (VII) nerve innervation of the orbicularis oculi muscles." . [] oboInOwl:hasDbXref "PMID:10732836", "PMID:25313414" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034253 ; owl:annotatedTarget "An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes." . [] oboInOwl:hasDbXref "PMID:14557570" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034254 ; owl:annotatedTarget "The face of the giant panda sign on T2-weighted MRI is characterized by preservation of normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, high signal in the tegmentum, and hypointensity of the superior colliculus. The findings are said to resemble the face of a giant panda." . [] oboInOwl:hasDbXref "PMID:30085532" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034255 ; owl:annotatedTarget "An aberrant, pathological communication between the colon and the bladder." . [] oboInOwl:hasDbXref "PMID:19945618" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034256 ; owl:annotatedTarget "Lack of demonstrable hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin." . [] oboInOwl:hasDbXref , "PMID:23117396", "PMID:27146825", "PMID:28838767" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034257 ; owl:annotatedTarget "The presence of autoantibodies (immunoglobulins) in the blood circulation that recognize C4b2a, the C3 convertase of the classical pathway of complement." . [] oboInOwl:hasDbXref "PMID:25561519" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034259 ; owl:annotatedTarget "A developmental defect characterized by underdevelopment of the mesencephalon." . [] oboInOwl:hasDbXref "PMID:26119818" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034260 ; owl:annotatedTarget "Developmental defect characterized by the absence of the zygomatic arch." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:5855592" . [] oboInOwl:hasDbXref "PMID:26119818", "PMID:30252348" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034262 ; owl:annotatedTarget "Lack of development of lanugo, the fine, soft, unpigmented hair on the body of a fetus or newborn baby." . [] oboInOwl:hasDbXref "PMID:21250125" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034263 ; owl:annotatedTarget "Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal." . [] oboInOwl:hasDbXref "PMID:25045355" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034264 ; owl:annotatedTarget "Postcoital bleeding (PCB) consists of spotting or bleeding after sexual intercourse that is not related to a person's menstrual cycle." . [] oboInOwl:hasDbXref "PMID:16533457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034265 ; owl:annotatedTarget "Pain in the breast." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034265 ; owl:annotatedTarget "Breast pain" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034265 ; owl:annotatedTarget "Painful breast" . [] oboInOwl:hasDbXref "PMID:32119472" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034267 ; owl:annotatedTarget "Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones." . [] oboInOwl:hasDbXref , "PMID:25439729" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034270 ; owl:annotatedTarget "Incisor teeth with irregular edges said to resemble a saw." . [] oboInOwl:hasDbXref "PMID:31466955" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034271 ; owl:annotatedTarget "Diffuse prominent gyral impressions on the inner table of skull vault said to resemble beaten copper." . [] oboInOwl:hasDbXref "PMID:34800980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034272 ; owl:annotatedTarget "Decreased amount of autofluorescence (emission of fluorescent light from ocular structures in the absence of sodium fluorescein) in the retina in the region surrounding the fovea." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:6368527" . [] oboInOwl:hasDbXref "PMID:19338976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034273 ; owl:annotatedTarget "Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation." . [] oboInOwl:hasDbXref "PMID:16184417" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034274 ; owl:annotatedTarget "A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae." . [] oboInOwl:hasDbXref "PMID:24364998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034275 ; owl:annotatedTarget "A type of epidermal nevus (which represent Blaschkoid hamartomas of the skin that result from mosaic post-zygotic mutations) that appears as skin-colored-to-brown, sharply demarcated, papillomatous papules that coalesce into plaques. The majority of these nevi are either present at birth or occur within the first year of life." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "PMID:908147" . [] oboInOwl:hasDbXref "PMID:11994986", "PMID:23744492" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034278 ; owl:annotatedTarget "Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis." . [] oboInOwl:hasDbXref "PMID:27372866", "PMID:32965812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034280 ; owl:annotatedTarget "Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target." . [] oboInOwl:hasDbXref "PMID:22503633" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034281 ; owl:annotatedTarget "Cone-shaped epiphyses of the phalanges of the hands or feet. Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery." . [] oboInOwl:hasDbXref "PMID:29059381" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034282 ; owl:annotatedTarget "Formation of abnormal, extraskeletal bony tissue in the soft tissue beneath the skin. Subcutaneous ossifications may be observed by radiography or by palpation." . [] oboInOwl:hasDbXref "PMID:8852667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034283 ; owl:annotatedTarget "Abnormally high concentration of protoporphyrin (derivative of porphyrin with propionic acid groups) in feces." . [] oboInOwl:hasDbXref "PMID:32491354" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034284 ; owl:annotatedTarget "Repeated occurrences of inflammatory condition of the gums (gingival tissue), most commonly caused by bacterial infection." . [] oboInOwl:hasDbXref "PMID:10537385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034286 ; owl:annotatedTarget "Pneumocystis carinii pneumonia is an opportunistic infection that occurs in immunosuppressed populations." . [] oboInOwl:hasDbXref "PMID:29883303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034288 ; owl:annotatedTarget "Abnormally increased concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034288 ; owl:annotatedTarget "Elevated rT3" . [] oboInOwl:hasDbXref "PMID:29883303" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034289 ; owl:annotatedTarget "An abnormally increased ratio of the concentrations of reverse T3 to T3 in the blood circulation." . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "Reaxys:1719752" . [] oboInOwl:hasDbXref "PMID:12696021" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034290 ; owl:annotatedTarget "Concentration of tiglylglycine in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:11326334" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034291 ; owl:annotatedTarget "An elevation above the normal range of creatine in the blood circulation." . [] oboInOwl:hasDbXref "PMID:20027545" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034293 ; owl:annotatedTarget "The presence of calcium deposition within the temporal lobe of the brain." . [] oboInOwl:hasDbXref "PMID:2028872", "PMID:22152905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034294 ; owl:annotatedTarget "Bile thrombi that form an obstruction (plug) in a dilated bile duct." . [] oboInOwl:hasDbXref "PMID:15367928" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034296 ; owl:annotatedTarget "Detection of 3,5,6-trichloro-2-pyridinol in the urine." . [] oboInOwl:hasDbXref "PMID:17336976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034297 ; owl:annotatedTarget "Elevated concentration of tetracosanoic acid (a C24 straight-chain saturated fatty acid) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:17336976" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034298 ; owl:annotatedTarget "Elevated concentration of hexacosanoic acid (a C26 straight-chain saturated fatty acid) in the blood circulation." . [] oboInOwl:hasDbXref "PMID:30484998" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034299 ; owl:annotatedTarget "A histological phenotype observed on testicular biopsy in which only Sertoli cells line the seminiferous tubules of the testis." . [] oboInOwl:hasDbXref "PMID:28413299" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034301 ; owl:annotatedTarget "A malformation of the colon in which a pouch-like dilatation of a varying degree of shortened colon is associated with an anorectal malformation. The pouch usually terminates in a fistulous communication with the genitourinary tract." . [] oboInOwl:hasDbXref "PMID:31926369" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034302 ; owl:annotatedTarget "A congenitally anomalous enlarged optic disk (surface area greater than 2.50 square millimeters). It is considered to be a normal variant without physiological defects." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:12950986" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "(2R,3R)-butane-1,2,3,4-tetrol" . [] oboInOwl:hasDbXref "PMID:29699857" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034303 ; owl:annotatedTarget "A bifid T-wave with a notch duration between the 2 peaks at leasy 0.04 sec and an amplitude at least 0.05 mV." . [] oboInOwl:hasDbXref "PMID:30796961" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034304 ; owl:annotatedTarget "An electric signal of depolarization observed between the end of the QRS complex and the beginning of the T wave." . [] oboInOwl:hasDbXref "PMID:23388215" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034305 ; owl:annotatedTarget "A type of second-degree atrioventricular block in which every other P wave is not conducted through the AV node such that only every other P wave is followed by a QRS complex." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034305 ; owl:annotatedTarget "2:1 AV block" . [] oboInOwl:hasDbXref "PMID:19043599" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034306 ; owl:annotatedTarget "An electrocardiographic finding of a normal QRS followed by a premature ventricular contraction; a rhythmic pairing of normal and atypical beats originating in the ventricles in a 1-1 ratio such that an ectopic ventricular beat follows each regular heartbeat." . [] oboInOwl:hasDbXref "PMID:25525505" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034307 ; owl:annotatedTarget "The LV end-diastolic internal diameter was measured from two-dimensional (2D) images in the parasternal long-axis view, timed with mitral valve closure at the level of the mitral valve chordae." . [] oboInOwl:hasDbXref "PMID:25425321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034308 ; owl:annotatedTarget "Abnormal increased in the duration of the P wave, which is a marker of delayed inter-atrial conduction." . [] oboInOwl:hasDbXref "PMID:21733974" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034309 ; owl:annotatedTarget "Spermatozoa with multiple flagella attached to the sperm head." . [] oboInOwl:hasDbXref "PMID:31270247" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034310 ; owl:annotatedTarget "Infection with the yellow fever virus of the live-attenuated vaccine." . [] oboInOwl:hasDbXref "PMID:23312594", "PMID:23591992" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034311 ; owl:annotatedTarget "Developmental defect characterized by undergrowth of the optic chiasm." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "D-threitol" . [] oboInOwl:hasDbXref "PMID:34630163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034312 ; owl:annotatedTarget "Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent." . [] oboInOwl:hasDbXref "PMID:26250903", "PMID:29083812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034313 ; owl:annotatedTarget "An abnoramlly increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent." . [] oboInOwl:hasDbXref "PMID:29083812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034314 ; owl:annotatedTarget "Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent." . [] oboInOwl:hasDbXref "PMID:29094873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034315 ; owl:annotatedTarget "A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children." . [] oboInOwl:hasDbXref "PMID:26209139" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034316 ; owl:annotatedTarget "Reduced volume of pars compacta of the substantia nigra." . [] oboInOwl:hasDbXref "PMID:21799704" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034318 ; owl:annotatedTarget "Reactivation is the mechanism whereby a latent virus that has infected a host cell switches to a lytic stage, undergoing productive viral replication and allowing the virus to spread. This term refers to reactivation regarded as unusual because of frequency, intensity, location, or nature of the virus, in the sense that the reactivation would not be observed in an immunocompetent host." . [] oboInOwl:hasDbXref "PMID:30400213" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034319 ; owl:annotatedTarget "A vasculopathy in the central nervous system (CNS) following reactivation of varicella-zoster virus due to a productive viral infection of both large and small cerebral arteries." . [] oboInOwl:hasDbXref "PMID:18274675" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034320 ; owl:annotatedTarget "Intracytoplasmic inclusions in myofibers that reduce nitro-blue tetrazolium (NBT) and thus stain strongly with the menadione-NBT stain." . [] oboInOwl:hasDbXref "PMID:15651030" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034321 ; owl:annotatedTarget "Concentration of guanidinoacetic acid in the blood circulation is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:34015306" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034322 ; owl:annotatedTarget "Diminished enzyme activity of galactocerebrosidase." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48300 ; owl:annotatedTarget "D-threo-tetritol" . [] oboInOwl:hasDbXref "PMID:33743755" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034324 ; owl:annotatedTarget "An abnormal widening (dilatation) of the brachiocephalic artery" . [] oboInOwl:hasDbXref "PMID:24771944", "PMID:30969690" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034326 ; owl:annotatedTarget "Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding." . [] oboInOwl:hasDbXref "PMID:29728753" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034327 ; owl:annotatedTarget "Thin, punctiform elements of various colors in the posterior stroma of the cornea, immediately anterior to Descemet membrane. The elements are visible to direct and indirect illumination." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034327 ; owl:annotatedTarget "Punctiform multicoloured opacities in the posterior corneal stroma" . [] oboInOwl:hasDbXref "PMID:18701947" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034328 ; owl:annotatedTarget "A condition in which the lumen of a bile duct has been filled by fibrous scar material, in effect replacing the bile duct with a fibrous scar." . [] oboInOwl:hasDbXref "PMID:29594439" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034329 ; owl:annotatedTarget "A congenital brain malformation characterized by marked overgrowth and dysplasia affecting one or both cerebral hemispheres, and, in some cases, subcortical brain regions as well. The presence of dysplasia in dysplastic megalencephaly distinguishes it from other forms of generalized megalencephaly." . [] oboInOwl:hasDbXref "PMID:16549640" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034330 ; owl:annotatedTarget "Decreased range of right ventricular motion in a portion of the right ventricle of the heart." . [] oboInOwl:hasDbXref "PMID:15664548" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034331 ; owl:annotatedTarget "Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle." . [] oboInOwl:hasDbXref "PMID:23281181", "PMID:28613652" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034336 ; owl:annotatedTarget "Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion." . [] oboInOwl:hasDbXref "PMID:29939558" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034337 ; owl:annotatedTarget "An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48343 ; owl:annotatedTarget "disulfides" . [] oboInOwl:hasDbXref "PMID:18660847" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034339 ; owl:annotatedTarget "A pattern of inheritance observed for alleles in the X-Y identical regions is referred to as pseudoautosomal inheritance, because it resembles the pattern seen for alleles located on autosomes." . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034340 ; owl:annotatedTarget "monoallelic_PAR" . [] oboInOwl:hasSynonymType obo:HP_0034334 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034341 ; owl:annotatedTarget "biallelic_PAR" . [] oboInOwl:hasDbXref "PMID:15517495", "PMID:24645840" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034346 ; owl:annotatedTarget "An abnormality of pancreatic beta cells characterized by a proliferation of abnormal beta cells throughout the entire pancreas, with enlarged islet size and number (hypertrophic islets), increased periductular islets, enlarged beta-cell nuclei and abundant clear cytoplasm. Occasionally beta cells with pleomorphic nuclei, ductuloinsular complexes, and neoformation of islets from ducts are observed." . [] oboInOwl:hasDbXref "PMID:34304616" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034348 ; owl:annotatedTarget "A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately below the pulmonary valve." . [] oboInOwl:hasDbXref "PMID:34304616" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034349 ; owl:annotatedTarget "A cardiovascular malformation associated with narrowing at the level of the pulmonary sinotubular junction above the pulmonic valve." . [] oboInOwl:hasDbXref "PMID:29554580" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034351 ; owl:annotatedTarget "Peripheral nerve hyperexcitability manifesting as spontaneous discharges originating from motor axons or their terminals, lead to overactivity of muscles, typically manifesting as twitches, cramps and stiffness." . [] oboInOwl:hasDbXref "PMID:23180925" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034354 ; owl:annotatedTarget "Transverse fractures through the hair shafts (trichoschisis). Trichoschisis is characterized by a sharp transverse fracture of the hair shaft." . [] oboInOwl:hasDbXref "PMID:29089832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034355 ; owl:annotatedTarget "On computed tomography of the brain,the white (or dense) cerebellum sign is seen when the cerebellum appears dense with respect to the cerebral parenchyma. The increase in attenuation of cerebellum is in fact a relative hyperdensity caused by decreased attenutation of the brain. It represents anoxic-ischemic cerebral injury, and has a very poor prognosis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034356 ; owl:annotatedTarget "Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48354 ; owl:annotatedTarget "polar solvent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034357 ; owl:annotatedTarget "Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034358 ; owl:annotatedTarget "Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption." . [] oboInOwl:hasDbXref "PMID:25287933", "PMID:31474092" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034359 ; owl:annotatedTarget "Increased fractional excretion (FE) of glucose in the phosphate. The FE of glucose is the percentage of the phosphate filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine phosphate, rather than by the interpretation of urinary phosphate concentration alone, as urinary glucose concentrations can vary with water reabsorption." . [] oboInOwl:hasDbXref "PMID:3080851" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034360 ; owl:annotatedTarget "A type of myoclonus (arrhythmic muscular jerking) that is induced by voluntary movement. It is made worse by attempts at precise or coordinated movement (intention myoclonus) and may also be provoked by certain sensory stimuli." . [] oboInOwl:hasDbXref "PMID:8944018" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034361 ; owl:annotatedTarget "Greater than normal amount of skin surrounding the umbilicus (belly button) with protrusion of the umbilicus above the plane of the abdomen." . [] oboInOwl:hasDbXref "PMID:34104871" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034363 ; owl:annotatedTarget "Corneal pterygium is an ocular surface disease characterized mainly by a wing-shaped growth of limbal and conjunctival tissue over the adjacent cornea." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034363 ; owl:annotatedTarget "Surfer's eye" . [] oboInOwl:hasDbXref "PMID:9691102" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034364 ; owl:annotatedTarget "Replacement of the myocardium of the right ventricular free wall by fat and fibrous tissue." . [] oboInOwl:hasDbXref "PMID:17560822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034365 ; owl:annotatedTarget "Increased concentration of alpha-aminoadipic semialdehyde in the blood circulation." . [] oboInOwl:hasDbXref "PMID:21691490" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034366 ; owl:annotatedTarget "Fracture blister is a type of blister that forms following acute bone fractures, typically near the ankle, wrist elbow or foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48354 ; owl:annotatedTarget "polar solvents" . [] oboInOwl:hasDbXref "PMID:32644527" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034368 ; owl:annotatedTarget "Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra." . [] oboInOwl:hasDbXref "PMID:16400613" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034369 ; owl:annotatedTarget "Reduced amount of coenzyme Q10,a naturally occurring quinone, in skeletal muscle tissue." . [] oboInOwl:hasDbXref "PMID:15461630" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034371 ; owl:annotatedTarget "Reduced concentration of prekallikrein (PK; also known as Fletcher factor) in the blood circulation. PK is the precursor of plasma kallikrein, a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII." . [] oboInOwl:hasDbXref "PMID:28744080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034374 ; owl:annotatedTarget "Abnormal appearance of the acetabulum characterized by spurs at the medial and lateral acetabular margin and in the center of the acetabulum, giving rise to shape resembling a three-pronged spear sadi to resemble a trident." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034374 ; owl:annotatedTarget "Trident acetabula" . [] oboInOwl:hasDbXref "PMID:32419552" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034377 ; owl:annotatedTarget "Regurgitation of the single atrioventricular valve regurgitation (AVVR) in the context of a congenital heart defect with a single ventricle. Roughly three quarters of patients following Fontan procedure display AVVR." . [] oboInOwl:hasDbXref "PMID:17183453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034379 ; owl:annotatedTarget "Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide." . [] oboInOwl:hasDbXref "NCIT:C4207", "PMID:17652550" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034380 ; owl:annotatedTarget "Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia." . [] oboInOwl:hasDbXref "PMID:27423618", "PMID:34678457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034381 ; owl:annotatedTarget "Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034382 ; owl:annotatedTarget "A decrease in or disappearance of signs and symptoms typically associated with a disease course." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48356 ; owl:annotatedTarget "protogenic solvent" . [] oboInOwl:hasDbXref "PMID:19580635" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034383 ; owl:annotatedTarget "Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation." . [] oboInOwl:hasDbXref "PMID:15161766" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034384 ; owl:annotatedTarget "Increased ratio of insulin to C-peptide in the blood circulation." . [] oboInOwl:hasDbXref "PMID:24451180" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034385 ; owl:annotatedTarget "A deviation from the normal range of the left ventricular endsystolic diameter." . [] oboInOwl:hasDbXref , "PMID:20952256" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034387 ; owl:annotatedTarget "Encephalitis caused by bacterial infection." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034388 ; owl:annotatedTarget "Hilar lymphadenopathy is swelling or enlargement of lymph nodes localised in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034389 ; owl:annotatedTarget "Pulmonary vein varix (PVV), refers to a localised dilatation of a pulmonary vein. PVV is a rare condition and can be congenital or acquired. PVV typically occur at the confluence of the veins adjacent to the left atrium. PVVs are sometimes classified into three morphological types: saccular, tortuous and confluent." . [] oboInOwl:hasDbXref "PMID:22938881", "PMID:26247029", "PMID:30928194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034392 ; owl:annotatedTarget "A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part." . [] oboInOwl:hasDbXref "PMID:33916495" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034396 ; owl:annotatedTarget "Hippocampal malrotation, also termed incomplete inversion of the hippocampus or hippocampal malformation, is an increasingly recognized neuroimaging finding of undetermined clinical significance. It is characterized by features including (i) Round or pyramidal shape instead of ovoid shape; (ii) Medial position of the hippocampus on the hippocampal sulcus; (iii) The collateral sulcus is excessively deep or verticalized; (iv) Fimbria located medial to the hippocampus; (v) Small or displaced fornix; (vi) Enlarged temporal horn and empty choroid fissure; (vii) Thickened subiculum; (viii) Reduced upper horizontal portion of the parahippocampal gyrus." . [] oboInOwl:hasDbXref "PMID:28461920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034397 ; owl:annotatedTarget "Claw toes are characterized by hyperextension at the metatarsal-phalangeal joints and flexion of the interphalangeal joints." . [] oboInOwl:hasDbXref "PMID:28461920" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034398 ; owl:annotatedTarget "Abnormal positioning of toe phalanges. Deformities of the lesser toes often occur gradually, though they can be brought on by trauma. The main adult sagittal plane deformities consist of claw toes, hammer toes and mallet toes. Axial plane deformities include crossover toes." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48359 ; owl:annotatedTarget "protophilic solvent" . [] oboInOwl:hasDbXref "PMID:24752292" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034399 ; owl:annotatedTarget "Increased duration of the central motor conduction time (CMCT). The CMCT estimates the conduction time of corticospinal fibers between motor cortex and spinal (or bulbar) motoneurons. It includes the times for excitation of cortical cells, conduction via the corticobulbar-corticospinal tract and excitation of the motoneuron sufficient to reach its firing threshold. CMCT is calculated by subtracting the peripheral conduction time from the MEP latency recorded after cortical stimulation." . [] oboInOwl:hasDbXref "PMID:26637975" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034400 ; owl:annotatedTarget "Ringed creases of the skin of the extremities related to folding of excess skin." . [] oboInOwl:hasDbXref "NCIT:C8715", "PMID:24982576", "PMID:33692948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034402 ; owl:annotatedTarget "A highly aggressive, extremely rare neoplasm of the kidney that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers, and pathologic diagnosis requires familiarity with these microscopic features plus awareness that adult onset is possible. It can be associated with abnormalities of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034402 ; owl:annotatedTarget "Malignant rhabdoid tumour of the kidney" . [] oboInOwl:hasDbXref "PMID:23518331" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034405 ; owl:annotatedTarget "Increasaed size of the tectum, which is the region of the midbrain posterior to the cerebral aqueduct of Sylvius. The midbrain is the most superior portion of the brainstem." . [] oboInOwl:hasDbXref "PMID:8993949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034408 ; owl:annotatedTarget "A dark, keratotic papule about 2-10 mm in diameter, usually occuring on the lower extremeities. Usually the lesions begin as bright, soft, and nonkeratotic paules which grow larger and change to a firm, blue to black and keratotic stage." . [] oboInOwl:hasDbXref "PMID:8993949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034409 ; owl:annotatedTarget "A type of angiokeratoma that most commonly occurs on the scrotum of patients who are 40 years old or older. The typical single lesion is a dark red to blue dome-shaped papule 2-4 mm in diameter with a very discrete keratotic surface. Typically, they are multiple and arranged in a line parallel to the raphe mediana of the scrotum. They also occur on the vulva and less commnly on the penis." . [] oboInOwl:hasDbXref "PMID:8993949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034410 ; owl:annotatedTarget "A type of angiokeratoma that typically presents in childhood as a large, mostly linear and unilateral hyperkeratotic plaque which is composed of confluent keratotic papules. The size ranges from a few centimeters up to a major part of the body surface. Initially the lesions present asa multile reddish macules, clinically similar to a nevus flammeus. Within several years they develop into acanthokeratotic papules that agrregate into plaques which may have a hyperkeratotic surface." . [] oboInOwl:hasDbXref "PMID:8993949" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034411 ; owl:annotatedTarget "A type of angiokeratoma that typically presents in women on the dorsa of fingers and toes and multiple dark red papules with a slightly verrucous surface, each measuring about 3-5 mm in diameter." . [] oboInOwl:hasDbXref "PMID:30969698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034415 ; owl:annotatedTarget "A type of dental trauma characterized by total dislocation of the tooth from its socket." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48359 ; owl:annotatedTarget "HBA solvent" . [] oboInOwl:hasDbXref "PMID:25426684" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034416 ; owl:annotatedTarget "Laceration or tear of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034417 ; owl:annotatedTarget "Intraoral lacerations" . [] oboInOwl:hasDbXref "PMID:30693460" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034418 ; owl:annotatedTarget "An erythematous lesion of the oral mucosa may result from a variety of tissue alterations, including inflammation, erythrocyte extravasation, and atrophy or reduced keratinization of the surface epithelium." . [] oboInOwl:hasDbXref "PMID:30470812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034419 ; owl:annotatedTarget "Breakage of the chordae tendinae of the mitral valve. This can lead to loss of tension of one of the mitral valve leaflets and mitral regurgitation." . [] oboInOwl:hasDbXref "PMID:27789759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034422 ; owl:annotatedTarget "Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. consisting of fibrinogen, fibronectin, alpha1-antitrypsin and alpha2-macroglobulin." . [] oboInOwl:hasDbXref "PMID:34147152" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034424 ; owl:annotatedTarget "A type of tinnitus that presents as clicks, resembling the noise made by the snapping together of 2 fingers." . [] oboInOwl:hasDbXref "PMID:11369901" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034425 ; owl:annotatedTarget "Abnormally low amount of sulfur in hair." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034425 ; owl:annotatedTarget "Hair sulphur content reduced" . [] oboInOwl:hasDbXref "PMID:32119282" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034426 ; owl:annotatedTarget "Secretion of colored sweat." . [] oboInOwl:hasDbXref "PMID:4236972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034428 ; owl:annotatedTarget "Disproportionately large eyelids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48359 ; owl:annotatedTarget "hydrogen bond acceptor solvent" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034429 ; owl:annotatedTarget "Bacteria in CSF" . [] oboInOwl:hasDbXref "PMID:21396557" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034432 ; owl:annotatedTarget "Applies to the localization of a skin lesion involving any area of the body where two opposing skin surfaces can touch and rub or chaff." . [] oboInOwl:hasDbXref , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034436 ; owl:annotatedTarget "Gaze aversion" . [] oboInOwl:hasDbXref "PMID:29182643" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034437 ; owl:annotatedTarget "Tendency to maintain sustained eye contact for an inappropriately long period of time." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:1371229" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48360 ; owl:annotatedTarget "amphiprotic solvent" . [] oboInOwl:hasDbXref "PMID:30725682" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034443 ; owl:annotatedTarget "Decreased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production." . [] oboInOwl:hasDbXref "PMID:21570468" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034448 ; owl:annotatedTarget "Any deviation from the normal ratio of blood phytanic acid concentration to pristanic acid concentration." . [] oboInOwl:hasDbXref "PMID:31822849" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034449 ; owl:annotatedTarget "An elevation above the normal ratio of blood phytanic acid concentration to pristanic acid concentration." . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "Beilstein:773698" . [] oboInOwl:hasDbXref "PMID:22900137" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034454 ; owl:annotatedTarget "Arachnoid granulations (AGs) are tufts of arachnoid membrane invaginated into the dural sinuses through which cerebrospinal fluid (CSF) enters the venous system. The lesions are primarily located in the parasagittal region along the superior sagittal sinus, which is occasionally seen at the transverse sinus. Normally dural venous sinus AGs typically range from 2 to 8 mm in size, but may grow enough to expand the dural sinuses, and even the inner table, diploic space and outer table of the skull." . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "CAS:4744-36-9" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "carbamimidic acid" . [] oboInOwl:hasDbXref "PMID:404321" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034463 ; owl:annotatedTarget "An increased concentration of hydroxylysine in the blood circulation. Hydroxylysine arises from a post-translational hydroxy modification of lysine and is unique to collagen and proteins containing collagen-like sequences. Elevated concentrations of hydroxylysine may indicate increased bone turnover." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "H2N-C(=NH)-OH" . [] oboInOwl:hasDbXref "PMID:32149048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034468 ; owl:annotatedTarget "Gastric xanthomas (also known as xanthelasmas) are are plaque-like red lesions defined by the presence of histiocytic containing lipids." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034468 ; owl:annotatedTarget "Gastric xanthomas" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034468 ; owl:annotatedTarget "Gastric xanthomata" . [] oboInOwl:hasDbXref "PMID:2651131" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034470 ; owl:annotatedTarget "Elevated amount of chloride in the stool." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034470 ; owl:annotatedTarget "Elevations in faecal chloride concentration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034471 ; owl:annotatedTarget "Increased faecal CIII:CI ratio" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034471 ; owl:annotatedTarget "Increased fecal CIII:CI ratio" . [] oboInOwl:hasDbXref "PMID:16614251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034476 ; owl:annotatedTarget "Identification of Clostridium botulinum toxin in the feces." . [] oboInOwl:hasDbXref "PMID:11528133" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034477 ; owl:annotatedTarget "Abnormal union of the membranous surfaces of the liver capsule and the parietal peritoneum due to inflammation or injury. Adhesions may be visualized by laparoscopy and may have a violin string appearance." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "H2N-C(OH)=NH" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034480 ; owl:annotatedTarget "Absent epididymides" . [] oboInOwl:hasDbXref "PMID:21427441" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034484 ; owl:annotatedTarget "The presence of calcium deposition in the spinal cord." . [] oboInOwl:hasDbXref "PMID:14672275" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034485 ; owl:annotatedTarget "A benign epithelial-lined cystic lesion that can occur anywhere in the neuraxis. Neuroepithelial cysts are ependymal or epithelial lined fluid collections of unknown etiology within the central nervous system parenchyma with no obvious ventricular or subarachnoid connection. Most cysts are asymptomatic, however, some present with seizures, mass effect, or rarely with movement disorders. On imaging, they present as CSF-like parenchymal cysts with smooth, rounded borders and minimal or no surrounding signal intensity abnormality." . [] oboInOwl:hasDbXref "PMID:19017411" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034492 ; owl:annotatedTarget "An inflammation of the fallopian tube." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "HO-C(=NH)-NH2" . [] oboInOwl:hasDbXref "PMID:28846347" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034493 ; owl:annotatedTarget "A tubo-ovarian abscess (TOA) is a complex infectious mass of the adnexa that forms as a sequela of pelvic inflammatory disease." . [] oboInOwl:hasDbXref "PMID:16369155" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034494 ; owl:annotatedTarget "White appearance (radio-opaqueness) of a paranasal sinus on radiography." . [] oboInOwl:hasDbXref "PMID:23396642" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034498 ; owl:annotatedTarget "Hepatic focal nodular hyperplasia (FNH) is a benign hepatic tumor. FNH develops within hepatic parenchymal tissue that is otherwise histologically normal. Macroscopically, the tumor is characterized by the presence of depressed, grayish-white scar, which is generally (but not always) located at the center of the lesion, with fibrous septa radiating outward, toward the periphery of the tumor. This stellate scar is found in only 50% of all FNH nodules, but its presence is regarded as pathognomonic. The lesion itself is usually lighter in color than the tissue that surrounds it, and it sometimes has a yellowish hue. FNH nodules are generally not capsulated; their margins are well defined, and they are sometimes lobulated." . [] oboInOwl:hasDbXref "PMID:70541" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034499 ; owl:annotatedTarget "An increased amount of iron in the bone marrow." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "Isoharnstoff" . [] oboInOwl:hasDbXref "PMID:31335046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034500 ; owl:annotatedTarget "A fracture of the glenoid fossa, a relatively shallow dish is located on the lateral scapula and is the socket portion of the shoulder joint that meets to articulate the humeral head." . [] oboInOwl:hasDbXref "PMID:30969712" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034501 ; owl:annotatedTarget "Abnormal increase in the width of the mediastinum, often defined as being greater than 6 to 8 cm." . [] oboInOwl:hasDbXref "PMID:32809510" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034503 ; owl:annotatedTarget "Ovarian torsion is a twisting of the ligaments that support the adnexa, cutting off the blood flow to the ovary." . [] oboInOwl:hasDbXref "PMID:19547674" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034504 ; owl:annotatedTarget "Septate gallbladder is characterized by the presence of a septum that divides the gallbladder in two chambers. When the septum dividing the gallbladder lies longitudinally it is called bilobed gallbladder and when there is a transverse septum separating the fundus from the rest of the gallbladder it is called an hour-glass gallbladder." . [] oboInOwl:hasDbXref "PMID:24370153" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034505 ; owl:annotatedTarget "Abnormal increased in the thickness of the wall of the gallbladder." . [] oboInOwl:hasDbXref "PMID:34496644" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034506 ; owl:annotatedTarget "Abnormal increased in the thickness of the size of the gallbladder." . [] oboInOwl:hasDbXref "PMID:32008911" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034508 ; owl:annotatedTarget "Fingerprint bodies are inclusion bodies located at the periphery of the muscle fibers underneath the sarcolemma (subsarcolemmal), consisting of non-membrane-bound packed lamellae arranged in concentric patterns resembling fingerprints." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034508 ; owl:annotatedTarget "Muscle biopsy: fingerprint bodies at periphery of muscle fibres" . [] oboInOwl:hasDbXref "PMID:571956" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034509 ; owl:annotatedTarget "An accumulation of myofilamentous material within individual muscle fibers, forming usually round but occasionally elongated bodies ranging from 2 to 15 pm in size. The so-called spheroid bodies stain green with the modified trichrome preparation and are mainly present in the periphery of type 1 muscle fibers, where they may occupy large sectors sharply demarcated from the remainder of the cross-sectioned muscle fiber." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "carbamimic acid" . [] oboInOwl:hasDbXref "PMID:29079705" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034511 ; owl:annotatedTarget "Diminished activity of the enzyne aconitase in muscle tissue." . [] oboInOwl:hasDbXref "PMID:11394453" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034512 ; owl:annotatedTarget "A cancer of the ureter that most often arises in the distal third of the ureter and is often diagnosed during the sixth and seventh decades of life. The most common presentation is gross hematuria or flank pain." . [] oboInOwl:hasDbXref "PMID:26015700" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034515 ; owl:annotatedTarget "Ameloblastoma is a benign odontogenic tumor generally present in the jaw bone. The tumor originates from the residual epithelium of the tooth germ, epithelium of odontogenic cysts stratified squamous epithelium and epithelium of the enamel organ." . [] oboInOwl:hasDbXref "PMID:27745832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034517 ; owl:annotatedTarget "Darkening of the area of skin that overlies the shin." . [] oboInOwl:hasDbXref "PMID:34741498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034518 ; owl:annotatedTarget "Gums that are easily damaged." . [] oboInOwl:hasDbXref "PMID:22405088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034521 ; owl:annotatedTarget "Scaling and overgrowth of horny tissue of the skin surrounding body orifices (including peri-auricular, peri-oral, peri-anal areas." . [] oboInOwl:hasDbXref "PMID:12731420" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034523 ; owl:annotatedTarget "Detection of a parasitic organism in the blood stream. Blood parasites include malaria plasmodia, microfilaria species, trypanosomes (the causative agents of African sleeping sickness and South American Changas disease) and the causative agents of schistosomiasis of the bladder and the intestine." . [] oboInOwl:hasDbXref "PMID:18279517" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034525 ; owl:annotatedTarget "A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns." . [] oboInOwl:hasDbXref "PMID:8998855" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034527 ; owl:annotatedTarget "Reduced activity of phosphoglycerate kinase (PGK) in muscle tissue. PGK is a glycolytic enzyme that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate." . [] oboInOwl:hasDbXref "PMID:10996775" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034529 ; owl:annotatedTarget "Diminished activity of the enzyme myoadenylate deaminase. Myoadenylate deaminase is the muscle isoform of adenosine monophosphate (AMP) deaminase and catalyzes the deamination of AMP to inosine monophosphate and ammonia." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:1379980" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "carbonamidimidic acid" . [] oboInOwl:hasDbXref "PMID:25250905" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034530 ; owl:annotatedTarget "A developmental defect of a long bone, such as the femur or the humerus, characterized by a sharply curve deviation located in the metaphysis (shaft) of the bone." . [] oboInOwl:hasDbXref "PMID:20693885" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034531 ; owl:annotatedTarget "A break or tear in the trachea." . [] oboInOwl:hasDbXref "PMID:30969670" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034533 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by exposure to a monoamine oxidase inhibitor." . [] oboInOwl:hasDbXref "PMID:32119293" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034534 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by exposure to a serotonin reuptake inhibitor." . [] oboInOwl:hasDbXref "PMID:17515875" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034541 ; owl:annotatedTarget "Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems." . [] oboInOwl:hasDbXref "PMID:11234560" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034542 ; owl:annotatedTarget "Long narrow depressions running lengthwise in hairshafts. This feature can be appreciated by scanning electron microsopy." . [] oboInOwl:hasDbXref "PMID:2498390" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034543 ; owl:annotatedTarget "Presence of viable mycobacteria in the blood." . [] oboInOwl:hasDbXref "PMID:21607145" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034545 ; owl:annotatedTarget "Increased activity of the enzyme pancreatic secretory trypsin inhibitor in the blood circulation." . [] oboInOwl:hasDbXref "PMID:25905393" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034546 ; owl:annotatedTarget "A developmental anomaly in which an individual with an X chromosome and a Y chromosome (usually 46,XY) has a uterus. The uterus and Fallopian tubes are derived from the Müllerian duct and thus this phenotype is generally also associated with the presence of Fallopian tubes." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "isourea" . [] oboInOwl:hasDbXref "PMID:34340048" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034549 ; owl:annotatedTarget "Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries" . [] oboInOwl:hasDbXref "PMID:8343045" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034550 ; owl:annotatedTarget "Infiltration of the wall of the small intestine by lymphocytes and mature plasma cells." . [] oboInOwl:hasDbXref "PMID:29083668" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034551 ; owl:annotatedTarget "Applies to a sign or symptom that is provoked or brought about by exposure to neuroleptic (also known as antipsychotic) medication." . [] oboInOwl:hasDbXref "PMID:35788297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034552 ; owl:annotatedTarget "Structural anomaly of peroxisomes, which are small, membrane-enclosed metabolic organelles with roles in the metabolism of complex lipids and reactive ionic species." . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48376 ; owl:annotatedTarget "pseudourea" . [] oboInOwl:hasDbXref "PMID:8940266" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034553 ; owl:annotatedTarget "Lack of observable peroxisomes. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy." . [] oboInOwl:hasDbXref "PMID:33692948" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034557 ; owl:annotatedTarget "Rhabdoid tumors are rare aggressive malignancies in infants and young children with a poor prognosis. The most common anatomic localizations are the central nervous system, the kidneys, and other soft tissues." . [] oboInOwl:hasDbXref "PMID:26076162", "PMID:26349416" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034558 ; owl:annotatedTarget "A highly aggressive, extremely rare neoplasm of the ovary that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers." . [] oboInOwl:hasDbXref "PMID:35883926" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034559 ; owl:annotatedTarget "A rare and aggressive neoplasms developing mainly in the kidney but also in cerebral and extra-cerebral tissues and rarely in the heart. Histologically, rhabdoid renal and extrarenal tumors share common characteristics. The cells are polygonal, with eccentric, vesicular nuclei and prominent nucleoli, eosinophilic cytoplasmic inclusions. The tumors have an infiltrative growth pattern, necrosis, and high proliferative index. The immunohistochemistry tools of investigation facilitate differential diagnosis by showing loss of INI-1 expression, usually accompanied by germline mutations of the SMARCB1 gene. When INI-1 is still expressed in the affected tissues, a rhabdoid tumor with SMARCA4 mutations should be considered." . [] oboInOwl:hasDbXref "PMID:31733273" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034560 ; owl:annotatedTarget "A rhabdoid tumor (a rare aggressive malignancies in infants and young children with a poor prognosis) originating in the urinary bladder." . [] oboInOwl:hasDbXref "PMID:33658498" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034562 ; owl:annotatedTarget "A malginant rhabdoid tumor (MRT) originating in muscle tissue." . [] oboInOwl:hasDbXref "PMID:15114530" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034565 ; owl:annotatedTarget "Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis." . [] oboInOwl:hasDbXref "PMID:27847606" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034567 ; owl:annotatedTarget "A developmental anomaloy characterized by congenital excavation of the optic nerve head." . [] oboInOwl:hasDbXref "PMID:30900187" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034570 ; owl:annotatedTarget "Increased width of the vascular wall of portal venules within the liver." . [] oboInOwl:hasDbXref "PMID:28139522" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034571 ; owl:annotatedTarget "Excessive proliferation of fibroblasts and deposition of extracellular matrix within the ovary." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48377 ; owl:annotatedTarget "imidic acid" . [] oboInOwl:hasDbXref "PMID:16045670", "PMID:6222085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034572 ; owl:annotatedTarget "A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation." . [] oboInOwl:hasDbXref "PMID:21176769" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034574 ; owl:annotatedTarget "Amount of keratin 10 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy." . [] oboInOwl:hasDbXref "PMID:26162928" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034581 ; owl:annotatedTarget "Presence of Trypanosoma cruzi in the blood stream. Trypanosoma cruzii is the etiological agent of Chagas disease." . [] oboInOwl:hasDbXref "PMID:22488251" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034583 ; owl:annotatedTarget "Lymph node with increased numbers of macrophages heavily laden with lipids." . [] oboInOwl:hasDbXref "PMID:16423553" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034584 ; owl:annotatedTarget "Structural anomal of pancreatic acinus." . [] oboInOwl:hasDbXref "PMID:25986071" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034585 ; owl:annotatedTarget "A developmental defect characterized by underdevelopment of the cochlear nerve." . [] oboInOwl:hasDbXref "PMID:29483667" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034586 ; owl:annotatedTarget "Level of glutathione in the urine above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:32034785" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034587 ; owl:annotatedTarget "Nevus psiloliparus is a rare fatty tissue nevus that is a marker for encephalocraniocutaneous lipomatosis, a neurocutaneous syndrome with ocular and central nervous system anomalies. Clinically, nevus psiloliparus is often described as a congenital alopecia and appears as an irregularly shaped, circumscribed area of alopecia on the scalp. Histopathology demonstrates a near-complete absence of mature hair follicles with preservation of arrector pili muscles and mature adipocytes within the dermis." . [] oboInOwl:hasDbXref "PMID:17021129" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034588 ; owl:annotatedTarget "Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodelling." . [] oboInOwl:hasDbXref "PMID:18252794" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034589 ; owl:annotatedTarget "Concentration of dehydroepiandrosterone-sulfate in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48377 ; owl:annotatedTarget "imidic acids" . [] oboInOwl:hasDbXref "PMID:24160257" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034601 ; owl:annotatedTarget "Concentration or activity of the C1q protein in the blood circulation below the lower limit of normal. C1q is the first component of the classical pathway and is composed of the C1qA chain, C1qB chain, and C1qC chain, which are encoded by C1qA, C1qB, and C1qC genes." . [] oboInOwl:hasDbXref "PMID:26530370" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034603 ; owl:annotatedTarget "Concentration of CA19-9 above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:83524" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034609 ; owl:annotatedTarget "Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia." . [] oboInOwl:hasDbXref "PMID:11062721" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034615 ; owl:annotatedTarget "Concentration of matrix metalloproteinase 2 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034621 ; owl:annotatedTarget "Lipid deposits localized within the liver. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034622 ; owl:annotatedTarget "Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034623 ; owl:annotatedTarget "Lipid deposits localized within the spleen. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034624 ; owl:annotatedTarget "Lipid deposits localized within the spinal cord. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034625 ; owl:annotatedTarget "Lipid deposits localized within the brain. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034626 ; owl:annotatedTarget "Lipid deposits localized within the lung. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48377 ; owl:annotatedTarget "imidic acids" . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034627 ; owl:annotatedTarget "Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:32965912" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034628 ; owl:annotatedTarget "Lipid deposits localized within one or more lymph nodes. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia." . [] oboInOwl:hasDbXref "PMID:19223950" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034629 ; owl:annotatedTarget "Xanthoma of bone is an exceedingly rare benign primary bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells." . [] oboInOwl:hasDbXref "PMID:11506403" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034633 ; owl:annotatedTarget "Diminished activity of the enzyme enolase in muscle tissue. The enzyme enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. In adult human muscle, over 90% of enolase activity is accounted for by the beta-enolase subunit, the protein product of the ENO3 gene." . [] oboInOwl:hasDbXref "PMID:19181099" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034635 ; owl:annotatedTarget "The presence of inclusion bodies within the cytoplasm of muscle cells that contain a mxiture of granules and filaments." . [] oboInOwl:hasDbXref "PMID:33690844" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034636 ; owl:annotatedTarget "Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow." . [] oboInOwl:hasDbXref "PMID:29569226", "PMID:32298062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034637 ; owl:annotatedTarget "A cylindroma located in the lung. Cylindromas are well-circumscribed, smooth, pale pink nodular tumors, often with arborizing vessels visible. The tumors are slow growing and vary in size from a few millimeters to over 5 mm." . [] oboInOwl:hasDbXref "PMID:32313484" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034639 ; owl:annotatedTarget "Presence of filaria in the blood stream. Filariasis is a common cause of elephantiasis in Coastal Districts of India. The initial manifestations are repeated episodes of fever with chills and rigor, lymphadenopathy which gradually progress to elephantiasis. In India filarial infestation is commonly caused by W. bancrofti and Brugia malayi, the former responsible for almost 98 percent of all cases." . [] oboInOwl:hasDbXref "PMID:31340993" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034641 ; owl:annotatedTarget "Presence of filariae in the skin." . [] oboInOwl:hasDbXref "PMID:33426564" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034642 ; owl:annotatedTarget "Accumulation of immunoglobulin A (IgA) surrounding dermal papillae, which are specialized cells that support the hair follicle." . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48377 ; owl:annotatedTarget "imino acids" . [] oboInOwl:hasDbXref "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034665 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the shoulder joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." . [] oboInOwl:hasDbXref "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034666 ; owl:annotatedTarget "Lack of the full expected passive range of flexion of the shoulder joint (Shoulder flexion puts the arms from a resting position at one's sides to straight above the head; thus, with shoulder extension contracture it is not possible to raise the arms above the head fully)." . [] oboInOwl:hasDbXref "PMID:36276237" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034668 ; owl:annotatedTarget "A myxoma (benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation) localized in the tongue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48378 ; owl:annotatedTarget "carboximidic acid" . [] oboInOwl:hasDbXref "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034671 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the knee joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034671 ; owl:annotatedTarget "Knee contractures" . [] oboInOwl:hasDbXref "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034672 ; owl:annotatedTarget "A type of knee joint contracture in which the knee lacks full expected flexion, such that the upper and lower leg cannot be brought together." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48378 ; owl:annotatedTarget "carboximidic acids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48378 ; owl:annotatedTarget "carboximidic acids" . [] oboInOwl:hasDbXref "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034675 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a toe joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." . [] oboInOwl:hasDbXref "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034676 ; owl:annotatedTarget "A type of toe joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together." . [] oboInOwl:hasDbXref "PMID:16214063", "PMID:24975760", "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034681 ; owl:annotatedTarget "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a finger joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin." . [] oboInOwl:hasDbXref "PMID:31282072" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034682 ; owl:annotatedTarget "A type of finger joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together." . [] oboInOwl:hasDbXref "PMID:19304569" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034686 ; owl:annotatedTarget "Activity of urocanase in the liver below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:6137805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034687 ; owl:annotatedTarget "Reduced hydrolysis (splitting of a bond and the addition of the hydrogen anion of water) of the sulfuric ester linkage in the molecule of cerebroside sulfate, possibly leading to accumuation of cerebroside sulfate." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:15102521" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48379 ; owl:annotatedTarget "isoureas" . [] oboInOwl:hasDbXref "PMID:6547838" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034688 ; owl:annotatedTarget "Diminished enzyme activity of peroxisomal glutaryl-CoA oxidase, an enzyme that metabolizes glutaryl-CoA (a metabolite of L-lysine, L-hydroxy-lysine and L-tryptophan) by dehydrogenation to glutaconyl-CoA directly followed by decarboxylation of this to crotonyl-CoA." . [] oboInOwl:hasDbXref "PMID:10856919" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034689 ; owl:annotatedTarget "Diminished activity of the enzyme sterol 27-hydroxylase, which participates in the degradation of cholesterol to bile acid. Sterol 27-hydroxylase catalyzes the first step in the normal oxidation of the steroid side chain, converting cholesterol, as well as different 7a-hydroxylated cholesterol metabolites, to 27-oxygenated steroids." . [] oboInOwl:hasDbXref "PMID:26989860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034690 ; owl:annotatedTarget "Diminished activbity of the enzyme Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid beta-oxidation that catalyses the first step in mitochondrial beta-oxidation of fatty acids." . [] oboInOwl:hasDbXref "PMID:30619878" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034691 ; owl:annotatedTarget "Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+." . [] oboInOwl:hasDbXref "PMID:33262702" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034692 ; owl:annotatedTarget "Increase in length of mitochondria." . [] oboInOwl:hasDbXref "PMID:20675163" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034693 ; owl:annotatedTarget "Activity of methionine adenosyltransferase in the liver below the lower limit of normal. Note that there are multiple methionine adenosyltransferase isoezymes." . [] oboInOwl:hasDbXref "PMID:30028088" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034694 ; owl:annotatedTarget "Degeneration and loss of neruons in the substantia nigra of the brain." . [] oboInOwl:hasDbXref "PMID:21772971" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0034698 ; owl:annotatedTarget "Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone." . [] oboInOwl:hasDbXref "PMID:9114819" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034702 ; owl:annotatedTarget "Any structural anomaly of the keratinocyte. The keratinocyte is the major cell type of the epidermis and is responsible for generating the protective barrier." . [] oboInOwl:hasDbXref "PMID:16493151" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034705 ; owl:annotatedTarget "Cellular inflammation, vessel destruction, and tissue necrosis of the blood vessels of the lung." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48379 ; owl:annotatedTarget "isoureas" . [] oboInOwl:hasDbXref "PMID:2537226" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034706 ; owl:annotatedTarget "Activity of D-glycerate kinase in the liver below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:16859547" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034707 ; owl:annotatedTarget "Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages in a lymph node." . [] oboInOwl:hasDbXref "PMID:19104687" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034708 ; owl:annotatedTarget "Underdevelopment of the upper branch of the pubis bone (inferior pubic ramus)." . [] oboInOwl:hasDbXref "PMID:30969628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034710 ; owl:annotatedTarget "A benign malformation of the lung that includes an abnormal mixture of tissue components such as cartilage, epithelium, fat, or muscle which are common to the lung but without preservation of the organ architecture." . [] oboInOwl:hasDbXref "PMID:15897506" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034711 ; owl:annotatedTarget "An abnormal histological finding characterized by an increase in the cross-section area of peripheral nerve axons (up to 20-25 micrometers in diameter)." . [] oboInOwl:hasDbXref "PMID:8171960" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034717 ; owl:annotatedTarget "The presence of enlarged and swollen neurons that lack Nissl bodies (the rough endoplasmic reticulum-achromasia refers to neurons that lack Nissl bodies) in the cortex of the brain." . [] oboInOwl:hasDbXref "PMID:34552114" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034719 ; owl:annotatedTarget "An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination." . [] oboInOwl:hasDbXref "PMID:33256177" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034720 ; owl:annotatedTarget "A type of skin tumor that initially presents as a reddish macule and subsequently becomes papular, enlarged, ulcerated and ultimately heals leaving pitted scars." . [] oboInOwl:hasDbXref "PMID:16685654" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034721 ; owl:annotatedTarget "Concentration of pristanic acid in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:21963049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034730 ; owl:annotatedTarget "Increased concentration of S-adenosyl-L-homocysteine in the blood circulation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48539 ; owl:annotatedTarget "alpha-adrenergic drugs" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034733 ; owl:annotatedTarget "Malignant hyperthermia with anaesthesia" . [] oboInOwl:hasDbXref "PMID:23938402" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034738 ; owl:annotatedTarget "Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health." . [] oboInOwl:hasDbXref "PMID:32809466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034746 ; owl:annotatedTarget "Abnormal increase in the number of Sertoli cells in the testis." . [] oboInOwl:hasDbXref "PMID:26652229" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034766 ; owl:annotatedTarget "Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in muscle fibers." . [] oboInOwl:hasDbXref "PMID:8989469" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034772 ; owl:annotatedTarget "Reduced anterioposterior dimension of the skull base." . [] oboInOwl:hasDbXref "PMID:21102332" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034773 ; owl:annotatedTarget "A visual disturbance in which objects in the visual field appear to oscillate (jump, jiggle, vibrate)." . [] oboInOwl:hasDbXref "PMID:2265915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034774 ; owl:annotatedTarget "The frequency with which the eye is blinked is below the lower limit of normal." . [] oboInOwl:hasDbXref "PMID:2265915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034775 ; owl:annotatedTarget "A deviation from the normal frequency of blinking the eye." . [] oboInOwl:hasDbXref "PMID:2265915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034776 ; owl:annotatedTarget "The frequecy with which the eye is blinked is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:34952006" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034781 ; owl:annotatedTarget "Excretion of pus (purulent discharge) from the opening of the parotid duct." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48540 ; owl:annotatedTarget "beta-adrenergic drugs" . [] oboInOwl:hasDbXref "PMID:31194424" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034788 ; owl:annotatedTarget "A pericardial friction rub is a grating, to-and-fro sound that occurs in phase with the heart sounds." . [] oboInOwl:hasDbXref "PMID:27556822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034790 ; owl:annotatedTarget "Any deviation from the normal amount of staining of succinate dehydrogenase in skeletal muscle tissue." . [] oboInOwl:hasDbXref , "PMID:21076438" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034794 ; owl:annotatedTarget "Pyriform spermatozoa consist of a normally shaped acrosomal structure which can be normal in size or enlarged, while the post-acrosomal region shows severe elongation and an acute narrowing to the posterior end, ending in about the same thickness as the connecting mid-piece." . [] oboInOwl:hasDbXref "ISBN:9789240030787" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034795 ; owl:annotatedTarget "Excess residual cytoplasm is associated with abnormal spermatozoa produced from a defective spermiation process. This abnormal excess cytoplasm should not be confused with more physiological cytoplasmic residues that can be observed in direct microscopy of the ejaculate but not in dried, fixed and stained morphology smears." . [] oboInOwl:hasDbXref "PMID:30969596" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034803 ; owl:annotatedTarget "The presence of blood in tears." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034803 ; owl:annotatedTarget "Bloody tears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034803 ; owl:annotatedTarget "Red tears" . [] oboInOwl:hasDbXref "PMID:17828787" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034806 ; owl:annotatedTarget "A perception that an object located in the vagina." . [] oboInOwl:hasDbXref "PMID:26933707" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034807 ; owl:annotatedTarget """Attacks of breathlessness that occur at night and may awaken the sleeping patient.""" . [] oboInOwl:hasDbXref "PMID:31939391" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034810 ; owl:annotatedTarget "Reduction in size of the acrosome below the lower limit of normal. The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus. According to the World Health Organization criteria, the acrosome must be clearly visible, comprising approximately 40-70 percent of the sperm head." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48560 ; owl:annotatedTarget "dopamine agent" . [] oboInOwl:hasDbXref "PMID:20111080" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034811 ; owl:annotatedTarget "The proportion of sperm cells whose flagella is sharply curved or has a sharp angle is above normal limits." . [] oboInOwl:hasDbXref "PMID:21866274" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034812 ; owl:annotatedTarget "Spermiation failure is indicated by apparently normal spermiogenesis, but the presence of retained Sd2 spermatids in stages III-V of human spermatogenesis, whereas maturation arrest is indicated by a lack of late Sd1 and Sd2 spermatids in the epithelium." . [] oboInOwl:hasDbXref "PMID:21346828" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034813 ; owl:annotatedTarget "A morphological abnormality visible upon biopsy of the germinal epithelium of the testis in which the cellularity of the germinal epithelium is reduced in general, so that all stages of germ cells (spermatogonia, spermatocytes, and spermatids) are present but reduced in number. This term applies to biopsies with some tubules showing diminished amounts of qualitatively complete spermatogenesis in combination with a vast majority of tubules that lack germ cells." . [] oboInOwl:hasDbXref "PMID:12185117" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034819 ; owl:annotatedTarget "The presence of a nodule (small rounded lump of tissue) in the iris." . [] oboInOwl:hasDbXref "PMID:8441952" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034820 ; owl:annotatedTarget "A type of iris nodule consisting of inflammatory cell precipitates which lie at the pupillary margin." . [] oboInOwl:hasDbXref "PMID:8441952" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034821 ; owl:annotatedTarget "A type of iris nodule consisting of inflammatory cell precipitates which lie on the iris surface." . [] oboInOwl:hasDbXref "PMID:9714385" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034824 ; owl:annotatedTarget "Diffuse lymphoid hyperplasia (DLH) describes the pathological entity that lies between follicular bronchiolitis and lymphocytic interstitial pneumonia (LIP). It is pathologically characterized by a diffuse peribronchiolar proliferation of hyperplastic lymphoid follicles (BALT), extended along the lymphatics to involve the interlobular septa and pleura. Unlike LIP, DHL does not show uniform involvement of the alveolar septa." . [] oboInOwl:hasDbXref "PMID:23034915" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034834 ; owl:annotatedTarget "Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in peripheral nerve fibers." . [] oboInOwl:hasDbXref "PMID:23662002" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034836 ; owl:annotatedTarget "A benign cystic neoplasm of the kidney." . [] oboInOwl:hasDbXref "PMID:27293393" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034837 ; owl:annotatedTarget "Elastic fibers not demonstrable in skin biopsy." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48560 ; owl:annotatedTarget "dopamine agents" . [] oboInOwl:hasDbXref "PMID:1246987" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034839 ; owl:annotatedTarget "An abnormal bone marrow finding characterized by many poorly circumscribed and occasionally confluent lymphoid nodules. The nodules contain small and uniform lymphocytes with rounded nuclei, clumped chromatin, and without prominent nucleoli." . [] oboInOwl:hasDbXref "PMID:22797297" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034840 ; owl:annotatedTarget "Lack of lamellar bodies (LBs) inthe epidermis. LBs are specialized organelles that contain pro-barrier lipids imparting a fully lamellar internal structure, but also other cargoes such as enzymes (lipid metabolizing and proteolytic), enzyme inhibitors, and antimicrobial peptides." . [] oboInOwl:hasDbXref "PMID:22559046", "PMID:24818161" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034842 ; owl:annotatedTarget "Increased size of sperm vacuoles, which are surface concavities typically located at the the tip or middle area of sperm heads. According to the WHO Laboratory Manual for the Examination and Processing of Human Semen, sperm head vacuoles are considered abnormal when exceeding 20% of the cross-sectional area of the head. Vacuoles are found in almost all samples with normal sperm morphology; this term applies if the proportion of sperm with abnormally large vacuoles is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:34283479" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034855 ; owl:annotatedTarget "A history of obesity, which can be defined as a body mass index of 30 or greater, in the mother of a fetus or index patient." . [] oboInOwl:hasDbXref "PMID:32644673" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034856 ; owl:annotatedTarget "A history of amniocentesis having been performed in the mother of a fetus or index patient." . [] oboInOwl:hasDbXref "PMID:25106696" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034864 ; owl:annotatedTarget "Activity of the enzyme alpha-galactosidase outsidebelow the lower limit of normal." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034882 ; owl:annotatedTarget "Prostatic calcul" . [] oboInOwl:hasDbXref "PMID:28632958" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034883 ; owl:annotatedTarget "A reduction in the velocity of portal venous flow, generally measured by Doppler ultrasound. Portal venous flow is normally towards the liver with peak systolic velocities in the range of 20-40 cm/s." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0034904 ; owl:annotatedTarget "Decreased circulating TRH concentration" . [] oboInOwl:hasDbXref "PMID:3311822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034913 ; owl:annotatedTarget "Reduction in the size of the acrosome of the head of spermatozoa." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48560 ; owl:annotatedTarget "dopamine drug" . [] oboInOwl:hasDbXref "PMID:28965849", "PMID:37073822" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034914 ; owl:annotatedTarget "Oocyte maturation arrest (OMA) can manifest as failed in vitro fetilization/intracytoplasmic sperm injection (IVF/ICSI) attempts using affected oocytes." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48560 ; owl:annotatedTarget "dopamine drugs" . [] oboInOwl:hasDbXref "PMID:20011334" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034917 ; owl:annotatedTarget "Reduced muscle tone of the sphincter of the anus." . [] oboInOwl:hasDbXref "PMID:2001873" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034920 ; owl:annotatedTarget "Inflammation of blood vessels in the mucosa of the nasal cavity." . [] oboInOwl:hasDbXref "PMID:11298373" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034925 ; owl:annotatedTarget "Deposition of a largely amorphous hyaline (transparent and homogeneous) substance around blood vessels in the dermis layer of the skin." . [] oboInOwl:hasDbXref "PMID:20226437", "PMID:30725734" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034927 ; owl:annotatedTarget "Abnormally large keratohyalin granules (KHG). KHG are typically present in the stratum granulosum of the epidermal layer of the skin (and epithelium of the mucosae). KHG are protein structures found in the keratinocytes of the stratum granulosum." . [] oboInOwl:hasDbXref "PMID:12189593" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034936 ; owl:annotatedTarget "Concentration of lathosterol in the blood circulation above the upper limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48560 ; owl:annotatedTarget "dopaminergic agents" . [] oboInOwl:hasDbXref "PMID:33089457" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034941 ; owl:annotatedTarget "A myxoma (A benign tumor composed of myxomatous tissue composed of loosely-arranged spindle, polygonal, and stellate cells) localized to the palate. Clinically, such tumors may present as a sessile nodule on the hard palate." . [] oboInOwl:hasDbXref "PMID:29606302" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034943 ; owl:annotatedTarget "Abnormally reduced amount of collagen fibers in the dermis." . [] oboInOwl:hasDbXref "PMID:29758285" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034944 ; owl:annotatedTarget "Abnormal shape of keratohyaline granules in dermal keratinocytes." . [] oboInOwl:hasDbXref "PMID:19559398" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034946 ; owl:annotatedTarget "Presence of many apocrine hidrocystoma (cysts) on the margins of the eyelids." . [] oboInOwl:hasDbXref "PMID:28008382" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034951 ; owl:annotatedTarget "A rare benign chondroid and osteoid matrix-producing neoplasm of bone characterized by extensive myxoid changes. OMX originate from bony cortices and have been observed in the nasal region, as well as the tibia and radius." . [] oboInOwl:hasDbXref "PMID:35239806" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034952 ; owl:annotatedTarget "A low-grade central nervous system tumor composed of dysplastic ganglion cells, usually presenting in children or young adults and located in the cerebral hemispheres." . [] oboInOwl:hasDbXref "PMID:28722872" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034953 ; owl:annotatedTarget "A gastrinoma, a neuroendocrine tumors characterized by the secretion of gastrin with resultant excessive gastric acid production, that is localized to the duodenum." . [] oboInOwl:hasDbXref "PMID:29201451" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034954 ; owl:annotatedTarget "A primary thymic neuroendocrine tumor." . [] oboInOwl:hasDbXref "PMID:27684977" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034955 ; owl:annotatedTarget "Count of eosinophils in the bone marrow above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:20301788" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034957 ; owl:annotatedTarget "Activity of glycogen debrancher enzyme (also known as amylo-1,6-glucosydase, 4-alpha-glucantransferase) in liver tissue below the lower limit of normal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48578 ; owl:annotatedTarget "free radical scavengers" . [] oboInOwl:hasDbXref "PMID:7511488" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034960 ; owl:annotatedTarget "The concentration of 3,6-epoxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal." . [] oboInOwl:hasDbXref "PMID:11276386" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034961 ; owl:annotatedTarget "Presence of biliary sludge (a mixture of particulate solids that have precipitated from bile) in the gallbladder. Such sediment consists of cholesterol crystals, calcium bilirubinate pigment, and other calcium salts. Sludge is usually detected on transabdominal ultrasonography." . [] oboInOwl:hasDbXref "PMID:1705800" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034964 ; owl:annotatedTarget "Width of the cavum septum pellucidum above the upper limit of normal, which is defined as a separation of greater than one cm of the leaves of the cavum septum pellucidum." . [] oboInOwl:hasDbXref "PMID:30725929" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034965 ; owl:annotatedTarget "Underdevelopment of the trochlear nerve, which is the fourth cranial nerve and one of the ocular motor nerves that controls eye movement." . [] oboInOwl:hasDbXref "PMID:29312727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034966 ; owl:annotatedTarget "A closed sac of tissue (cyst) located in the thymus. Thymic cysts are a rare, benign anomaly, are usually asymptomatic, and mostly occur in the anterior mediastinum ." . [] oboInOwl:hasDbXref "PMID:23091995" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034967 ; owl:annotatedTarget "A closed sack of tissue (cyst) located in the uterus." . [] oboInOwl:hasDbXref "PMID:3976367" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034973 ; owl:annotatedTarget "Congenital absence of the pyramids, that is, of the paired structures located at the medial aspect of the ventral medulla that flank the anterior median fissure." . [] oboInOwl:hasDbXref "PMID:21970727" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034974 ; owl:annotatedTarget "A deformity of the posterior skull with bulging of the midportion of the occipital bone that is often associated with a benign variant of the mendosal suture." . [] oboInOwl:hasDbXref "PMID:31336972" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034975 ; owl:annotatedTarget "Downward pointing exostoses of the occipital bone situated in the tendinous insertions of the sternocleidomastoid and trapezius muscles." . [] oboInOwl:hasDbXref "PMID:25250085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034976 ; owl:annotatedTarget "A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:15385432" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48578 ; owl:annotatedTarget "free-radical scavenger" . [] oboInOwl:hasDbXref "PMID:25654066" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034977 ; owl:annotatedTarget "A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." . [] oboInOwl:hasDbXref "PMID:25250085" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034978 ; owl:annotatedTarget "A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland." . [] oboInOwl:hasDbXref "PMID:18470836" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034979 ; owl:annotatedTarget "Unintentional movement in one area of the face produced during intentional movement of another area of the face." . [] oboInOwl:hasDbXref "PMID:28846263" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034984 ; owl:annotatedTarget "A history of exposure during pregnancy of the mother of a fetus or child to ethanol (alcohol)." . [] oboInOwl:hasDbXref "PMID:35881752" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034997 ; owl:annotatedTarget "Reduced number of small nerve fibers in the skin." . [] oboInOwl:hasDbXref "PMID:27504194" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034998 ; owl:annotatedTarget "A developmental defect characterized by the presence of a supernumerary femoral artery." . [] oboInOwl:hasDbXref "PMID:19726672", "PMID:8288900" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0034999 ; owl:annotatedTarget "Collagen VII is the major molecular constituent of anchoring fibrils in the skin. Collagen VII is synthesized as three identical pro-alpha1(VII) polypeptide chains, which are hydroxylated and glycosylated in a coordinated manner and then fold into triple-helical procollagen VII in the endoplasmic reticulum (ER). Mature collagen VII undergoes a multistep fibril polymerization process to form the anchoring fibrils. Mutant pro-alpha1(VII) polypeptide chains or procollagen VII molecules do not pass the ER quality control and are retained in the ER or designated for ubiquitin-proteasome degradation resulting in reduced amounts of collagen VII in the skin." . [] oboInOwl:hasDbXref "PMID:30855850" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0035012 ; owl:annotatedTarget "Any structural abnormality of the femoral artey, a large blood vessel that provides oxygenated blood to lower extremity structures and in part to the lower anterior abdominal wall." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48705 ; owl:annotatedTarget "agonist" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48705 ; owl:annotatedTarget "agonista" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040007 ; owl:annotatedTarget "Lack of skin pigmentation (coloring) of the chest." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040007 ; owl:annotatedTarget "Lack of skin coloring on chest" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040007 ; owl:annotatedTarget "Lack of skin colouring on chest" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48705 ; owl:annotatedTarget "agoniste" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Failure of development of facial skeleton" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Absence of facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Agenesis of facial bones" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Aplasia of facial skeleton" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48705 ; owl:annotatedTarget "agonists" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Failure of development of facial bones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0040008 ; owl:annotatedTarget "Missing facial bones" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48706 ; owl:annotatedTarget "antagonist" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48706 ; owl:annotatedTarget "antagonista" . [] oboInOwl:hasDbXref , "PMID:12407692" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040012 ; owl:annotatedTarget "Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48706 ; owl:annotatedTarget "antagoniste" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48706 ; owl:annotatedTarget "antagonists" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040016 ; owl:annotatedTarget "Prominent tailbone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:15546874" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040017 ; owl:annotatedTarget "Protruding tailbone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040018 ; owl:annotatedTarget "Curvature of big toe" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "CAS:7782-99-2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040019 ; owl:annotatedTarget "Curvature of finger" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "Gmelin:1458" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040022 ; owl:annotatedTarget "Curvature of index finger" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "UM-BBD_compID:c0348" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040023 ; owl:annotatedTarget "Curvature of thumb" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "Sulfurous acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040024 ; owl:annotatedTarget "Curvature of middle finger" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040025 ; owl:annotatedTarget "Curvature of ring finger" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "dihydrogen trioxosulfate" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "dihydroxidooxidosulfur" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "sulfurous acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "trioxosulfuric acid" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "H2SO3" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:1567198" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "S(O)(OH)2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040032 ; owl:annotatedTarget "Small upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040032 ; owl:annotatedTarget "Decreased size of upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040032 ; owl:annotatedTarget "Underdevelopment of upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0040032 ; owl:annotatedTarget "Short upper eyelid" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "Sulfite" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040032 ; owl:annotatedTarget "Hypotrophic upper eyelid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040033 ; owl:annotatedTarget "Absent/small 5th long bone of foot" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040033 ; owl:annotatedTarget "Absent/underdeveloped 5th long bone of foot" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "[SO(OH)2]" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040034 ; owl:annotatedTarget "Abnormality of the 2nd long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "acide sulfureux" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040035 ; owl:annotatedTarget "Abnormality of the 4th long bone of foot" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "acido sulfuroso" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040036 ; owl:annotatedTarget "Overgrowth and curving of fingernail" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "schweflige Saeure" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040039 ; owl:annotatedTarget "Detachment of fingernails" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48854 ; owl:annotatedTarget "sulphurous acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040040 ; owl:annotatedTarget "Detachment of toenails" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "Anticholinergika" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040042 ; owl:annotatedTarget "Absent eccrine sweat glands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040043 ; owl:annotatedTarget "Underdeveloped major sweat glands" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "Anticholinergikum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040044 ; owl:annotatedTarget "Underdeveloped diaphragm" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "acetylcholine antagonists" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040049 ; owl:annotatedTarget "Thickening of the retina that takes place due to accumulation of fluid in the macula as a nonspecific response to blood-retinal barrier breakdown. Macular edema is a common pathological response to a wide variety of ocular insults, most commonly after intraocular (e.g. cataract) surgery or in association with retinal vascular (e.g. diabetic eye disease, retinal vein occlusion) or inflammatory (e.g. uveitis) disease." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040049 ; owl:annotatedTarget "Macular oedema" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:15939439" . [] oboInOwl:hasDbXref "IUPHAR" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "acetylcholine receptor antagonist" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040050 ; owl:annotatedTarget "Hypotrichosis of upper eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040050 ; owl:annotatedTarget "Partial absence of upper eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040050 ; owl:annotatedTarget "Sparse upper eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "agent anticholinergique" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040051 ; owl:annotatedTarget "Abnormality of upper eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "agente anticolinergico" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040052 ; owl:annotatedTarget "Abnormality of lower eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "agentes anticolinergicos" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040053 ; owl:annotatedTarget "Increased length of lower eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040053 ; owl:annotatedTarget "Long lower eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040054 ; owl:annotatedTarget "Decreased length of upper eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "anticholinergic agents" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040054 ; owl:annotatedTarget "Short upper eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040055 ; owl:annotatedTarget "Decreased length of lower eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040055 ; owl:annotatedTarget "Short lower eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "anticholinergics" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040056 ; owl:annotatedTarget "Absent upper eyelashes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040056 ; owl:annotatedTarget "Failure of development of upper eyelashes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0040056 ; owl:annotatedTarget "Agenesis of upper eyelashes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "anticholinergiques" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0040056 ; owl:annotatedTarget "Aplasia of upper eyelashes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040057 ; owl:annotatedTarget "Abnormality of nasal hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040057 ; owl:annotatedTarget "Abnormality of nose hair" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "anticolinergicos" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48873 ; owl:annotatedTarget "cholinergic-blocking agents" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:16212238" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040063 ; owl:annotatedTarget "Decreased fat tissue" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48927 ; owl:annotatedTarget "N-Acyl-L-amino acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040064 ; owl:annotatedTarget "Abnormal limbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040064 ; owl:annotatedTarget "Abnormality of limbs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040064 ; owl:annotatedTarget "Limb anomaly" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040064 ; owl:annotatedTarget "Dysmelia" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48937 ; owl:annotatedTarget "Beilstein:1744639" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040068 ; owl:annotatedTarget "Abnormality of limb bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040069 ; owl:annotatedTarget "Abnormal shape of bones of the lower limbs" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48937 ; owl:annotatedTarget "CAS:638-36-8" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040069 ; owl:annotatedTarget "Abnormality of lower limb bone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040070 ; owl:annotatedTarget "Abnormal shape of bones of the upper limbs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040070 ; owl:annotatedTarget "Abnormality of upper limb bone" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48937 ; owl:annotatedTarget "2,6,10,14-tetramethylhexadecane" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48937 ; owl:annotatedTarget "Phytan" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040072 ; owl:annotatedTarget "Abnormality of forearm bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040079 ; owl:annotatedTarget "Irregular teeth" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040081 ; owl:annotatedTarget "Any deviation from the normal circulating creatine kinase concentration." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040081 ; owl:annotatedTarget "Abnormal circulating CK concentration" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040081 ; owl:annotatedTarget "Abnormal circulating CPK concentration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040081 ; owl:annotatedTarget "Abnormal levels of creatine kinase in blood" . [] oboInOwl:hasDbXref "PMID:18830393" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040082 ; owl:annotatedTarget "A conspicuously happy disposition with frequent smiling and laughing that may be context-inappropriate or unrelated to context." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040082 ; owl:annotatedTarget "Happy demeanor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040082 ; owl:annotatedTarget "Happy demeanour" . [] oboInOwl:hasDbXref "PMID:26709689" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040083 ; owl:annotatedTarget "Toe walking is a pattern of walking in which a person walks on balls of his or her feet, with no contact between the heels and ground. Toe-walking is common in children who are learning to walk, but most children outgrow it around the age of two years. This term refers to the persistance of toe-walking beyond the usual age." . [] oboInOwl:hasDbXref "PMID:12949225" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040084 ; owl:annotatedTarget "A deviation from the normal concentration of renin in the blood, a central hormone in the control of blood pressure and various other physiological functions." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040084 ; owl:annotatedTarget "Abnormal circulating renin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040084 ; owl:annotatedTarget "Abnormal plasma renin" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:16341241" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "Beilstein:3903644" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "CAS:5711-69-3" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040085 ; owl:annotatedTarget "Abnormal circulating aldosterone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040085 ; owl:annotatedTarget "Abnormal plasma aldosterone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040086 ; owl:annotatedTarget "Abnormal prolactin level" . [] oboInOwl:source "NIST Chemistry WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "CAS:5711-69-3" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040087 ; owl:annotatedTarget "Abnormal serum folate" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "Gmelin:324364" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040088 ; owl:annotatedTarget "Abnormal lymphocyte count" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040088 ; owl:annotatedTarget "Abnormal lymphocyte counts" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040088 ; owl:annotatedTarget "Abnormal number of lymphocytes" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040088 ; owl:annotatedTarget "Abnormal numbers of lymphocytes" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040088 ; owl:annotatedTarget "Abnormality of lymphocyte number" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "Reaxys:3903644" . [] oboInOwl:hasDbXref "PMID:19278419" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040089 ; owl:annotatedTarget "Any deviation from the normal overall count of natural killer (NK) cells in the circulation or a deviation from the normal distribution of NK cell subtypes." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040089 ; owl:annotatedTarget "Abnormal NK cell count" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040089 ; owl:annotatedTarget "Abnormal number of natural killer cells" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040089 ; owl:annotatedTarget "Abnormality of natural killer cell count" . [] oboInOwl:source "UM-BBD" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "UM-BBD_compID:c0383" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040090 ; owl:annotatedTarget "Abnormality of the eardrum" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040091 ; owl:annotatedTarget "Asymmetry of the size of ears" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040092 ; owl:annotatedTarget "Asymmetry of the shape of the ears" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040093 ; owl:annotatedTarget "Uneven ears" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "2-methylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040095 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the outer ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040095 ; owl:annotatedTarget "Outer ear tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040095 ; owl:annotatedTarget "Outer ear tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040096 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the inner ear." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040096 ; owl:annotatedTarget "Inner ear tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040096 ; owl:annotatedTarget "Inner ear tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040097 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the ceruminal gland." . [] oboInOwl:hasDbXref "PMID:34383758" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040115 ; owl:annotatedTarget "A structural anomaly of the Eustachian tube (ET). The ET is a biomechanical valve between the nasopharynx and the middle ear. Physiologically, it controls the passive adaptation of the middle ear air pressure to the ambient air pressure primarily via direct muscular actions of the soft palate. In the closed state it protects the middle ear. Inadequate function of the ET causes middle ear ventilation disorders." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040116 ; owl:annotatedTarget "Absent eustachian tube" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "2-methylpropanoate" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "2-methylpropanoic acid, ion(1-)" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040126 ; owl:annotatedTarget "A deviation from the normal concentration of cobalamin (vitamin B12) in the blood. Vitamin B12 is one of the eight B vitamins." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "2-methylpropionate" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:16574813" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "Isobutyrat" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "i-butyrate" . [] oboInOwl:hasDbXref , "PMID:29723227" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040133 ; owl:annotatedTarget "A deviation from the normal circulating concentration of ferritin. Ferritin concentration can be measured in serum or plasma." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040133 ; owl:annotatedTarget "Abnormal serum ferritin" . [] oboInOwl:hasDbXref "NIST_Chemistry_WebBook" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "iPrCO2 anion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040134 ; owl:annotatedTarget "Abnormal liver iron concentration" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040134 ; owl:annotatedTarget "Abnormal liver iron level" . [] oboInOwl:hasDbXref "PMID:15083853" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040135 ; owl:annotatedTarget "Any abnormality in the serum transferrin saturation, which is calculated by dividing the serum iron level by total iron-binding capacity." . [] oboInOwl:hasDbXref "PMID:18177407" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040137 ; owl:annotatedTarget "A type of acne in which open and closed comedones comprise the majority of the lesions, with substantially fewer papules and pustules." . [] oboInOwl:hasDbXref "PMID:10606860" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040138 ; owl:annotatedTarget "Multiple subcutaneous non-fragile and skin-coloured papules characterized by interstitial infiltrate of spindle and epithelioid histiocytes, and mucin. There are well circumscribed aggregates of epithelioid histiocytes and mucin in the upper and middle dermis,with the histiocytes arranged between collagen bundles and separated from the epidermis by a Grenz zone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "isobutanoate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "isobutyric acid anion" . [] oboInOwl:hasDbXref "PMID:6790862" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040142 ; owl:annotatedTarget "Decreased level of the reaction 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48944 ; owl:annotatedTarget "methylpropanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040144 ; owl:annotatedTarget "An increase in the level of L-2-hydroxyglutaric acid in the urine." . [] oboInOwl:hasDbXref "PMID:21339907" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040148 ; owl:annotatedTarget "Cortical myoclonus mainly affects the distal upper limbs and face, which reflects the largest cortical representations of these body areas. It is often focal, but may be multifocal, bilateral or generalized, as a consequence of intracortical and transcallosal spreading of abnormal activity. It typically occurs on voluntary action and may affect speech and gait. Cortical myoclonic jerks are stimulus sensitive, typically to touch, but sensitivity to visual stimuli is also described. Most patients with cortical myoclonus have both positive myoclonus and NM, occurring either independently or together as a complex of the two kinds of myoclonus. If cortical myoclonus is prolonged and lasts for hours, days or weeks, it is called epilepsia partials continua and is considered to be a rare form of focal epileptic status. Focal cortical myoclonus almost always points to an underlining lesion of the sensori-motor cortex, which produces hyperexcitability (e.g. vascular, inflammatory or neoplastic)." . [] oboInOwl:hasDbXref "PMID:20464096" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040149 ; owl:annotatedTarget "The presence of woolly hair on the scalp. The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040149 ; owl:annotatedTarget "Nappy scalp hair texture" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040149 ; owl:annotatedTarget "Afro-textured scalp hair" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040149 ; owl:annotatedTarget "Kinky scalp hair texture" . [] oboInOwl:hasDbXref "https://www.news-medical.net/health/What-is-Hidradenitis-suppurativa-(acne-inversa).aspx" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040154 ; owl:annotatedTarget "A chronic skin condition involving the inflammation of the apocrine sweat glands, forming pimple-like bumps known as abscesses." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040154 ; owl:annotatedTarget "Hidradenitis suppurativa" . [] oboInOwl:hasDbXref "PMID:23439959" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040154 ; owl:annotatedTarget "Pyoderma fistulans significa" . [] oboInOwl:hasDbXref "PMID:23439959" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040154 ; owl:annotatedTarget "Smoker's boils" . [] oboInOwl:hasDbXref "PMID:23439959" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040154 ; owl:annotatedTarget "Verneuil's disease" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:167132" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "Reaxys:3905591" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "(4-hydroxyphenyl)acetate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040159 ; owl:annotatedTarget "Abnormal spaced incisors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040159 ; owl:annotatedTarget "Abnormality of spacing of front teeth" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "4-hydroxyphenylacetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040159 ; owl:annotatedTarget "Abnormality of spacing of incisors" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040160 ; owl:annotatedTarget "Generalised osteoporosis" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040160 ; owl:annotatedTarget "Generalised osteoporosis with pathologic fractures" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040161 ; owl:annotatedTarget "Localised osteoporosis" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "(p-hydroxyphenyl)acetate" . ( ) . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040163 ; owl:annotatedTarget "Abnormal shape of pelvis bone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040164 ; owl:annotatedTarget "Fatty tumors on the eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040164 ; owl:annotatedTarget "Fatty tumors on the eyelids" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040164 ; owl:annotatedTarget "Fatty tumours on the eyelids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "2-(4-hydroxyphenyl)ethanoate" . [] dcterms:creator ; a owl:Axiom ; owl:annotatedProperty owl:equivalentClass ; owl:annotatedSource obo:HP_0040165 ; owl:annotatedTarget _:genid95540 . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040167 ; owl:annotatedTarget "Facial verruca" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040167 ; owl:annotatedTarget "Facial wart" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_48999 ; owl:annotatedTarget "4-hydroxybenzeneacetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasBroadSynonym ; owl:annotatedSource obo:HP_0040171 ; owl:annotatedTarget "Decreased testosterone" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040171 ; owl:annotatedTarget "Decreased serum testosterone level" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040171 ; owl:annotatedTarget "Decreased serum testosterone levels" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040171 ; owl:annotatedTarget "Low serum testosterone level" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040171 ; owl:annotatedTarget "Low serum testosterone levels" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040173 ; owl:annotatedTarget "Abnormality of lingual muscle" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040173 ; owl:annotatedTarget "Abnormality of the tongue muscle" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040174 ; owl:annotatedTarget "Abnormality of extrinsic lingual muscle" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:1724444" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_49096 ; owl:annotatedTarget "PMID:17190852" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Chapped lip" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_49096 ; owl:annotatedTarget "3-amino-2-methylpropanoate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Chapped lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Cheilitis simplex" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Common cheilitis" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Dry lips" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0040181 ; owl:annotatedTarget "Perioral dermatitis" . [] oboInOwl:hasDbXref , "PMID:15763524" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040182 ; owl:annotatedTarget "Inappropriate sinus tachycardia is a nonparoxysmal tachyarrhythmia characterized by an increased resting heart rate (HR) and/or an exaggerated HR response to minimal exertion or a change in body posture. HR is constantly above the physiological range with no appropriate relation to metabolic or physiological demands." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040183 ; owl:annotatedTarget "Stool holding" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040183 ; owl:annotatedTarget "Stool soiling" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49096 ; owl:annotatedTarget "beta-aminoisobutyrate" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040184 ; owl:annotatedTarget "Oral bleeding" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49167 ; owl:annotatedTarget "anti-asthmatic agent" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040184 ; owl:annotatedTarget "Oral haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040184 ; owl:annotatedTarget "Oral hemorrhage" . [] oboInOwl:hasDbXref "PMID:19398898" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040186 ; owl:annotatedTarget "A skin rash that is characterized by diffuse cutaneous erythema with areas of skin elevation. It may evolve to vesicles or papules as part of a more severe clinical entity. Different degrees of angioedema with involvement of subcutaneous tissue may also appear." . [] oboInOwl:hasDbXref "PMID:4067741" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040187 ; owl:annotatedTarget "Systemic inflammatory response to infection in newborn babies." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040189 ; owl:annotatedTarget "Scaling skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040189 ; owl:annotatedTarget "Scaly skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040189 ; owl:annotatedTarget "flaking skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040189 ; owl:annotatedTarget "peeling skin" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040190 ; owl:annotatedTarget "White scaling skin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040190 ; owl:annotatedTarget "White scaly skin" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49167 ; owl:annotatedTarget "anti-asthmatic agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49167 ; owl:annotatedTarget "anti-asthmatic drugs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040194 ; owl:annotatedTarget "Increased head circumference" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49302 ; owl:annotatedTarget "2-hydroxy acid" . [] oboInOwl:hasDbXref "PMID:26505062" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040195 ; owl:annotatedTarget "An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040195 ; owl:annotatedTarget "Decreased head circumference" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040197 ; owl:annotatedTarget "Encephalomalacia is the softening or loss of brain tissue after cerebral infarction, cerebral ischemia, infection, craniocerebral trauma, or other injury." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040197 ; owl:annotatedTarget "Cerebral softening" . [] oboInOwl:hasDbXref , "DOI:10.1007/978-0-387-79948-3_2046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040200 ; owl:annotatedTarget "The inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040200 ; owl:annotatedTarget "Negative chorea" . [] oboInOwl:hasDbXref , "DOI:10.1007/978-0-387-79948-3_2046", "PMID:17353476" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0040200 ; owl:annotatedTarget "Damage to premotor and prefrontal regions results in motor-intentional disorders that disrupt initiation, maintenance, and termination of volitional movements. Motor impersistence (i.e., failure to maintain movement) more frequently develops following right than left hemisphere lesions." . [] oboInOwl:hasDbXref , "DOI:10.1007/978-0-387-79948-3_2046" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040201 ; owl:annotatedTarget "A subset of motor impersistence, defined as the inability to perform more than two of the simple voluntary acts simultaneously, such as closing the eyes and protruding the tongue." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49302 ; owl:annotatedTarget "2-hydroxy monocarboxylic acids" . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040202 ; owl:annotatedTarget "Abnormal consumption behaviour" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49323 ; owl:annotatedTarget "contraceptive agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49323 ; owl:annotatedTarget "contraceptive drugs" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:19364317" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "hydrogen" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "1H" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "H" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "Wasserstoff" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "hidrogeno" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "hydrogen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_49637 ; owl:annotatedTarget "hydrogene" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040213 ; owl:annotatedTarget "Shallow breathing" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:21149694" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50047 ; owl:annotatedTarget "organic amino compounds" . [] oboInOwl:hasDbXref , "PMID:20042774" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "Elevated HbA1c" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "Elevated glycated haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "Elevated glycosylated haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "Elevated haemoglobin A1c" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040217 ; owl:annotatedTarget "Increased HbA1c levels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50103 ; owl:annotatedTarget "excitatory amino acid agonists" . [] oboInOwl:hasDbXref , "PMID:23993353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040218 ; owl:annotatedTarget "Less than normal number of natural killer cells, a type of lymphocyte in the innate immune system with an ability to mediate cytotoxicity and produce cytokines after the ligation of a germline-encoded activation receptor." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040218 ; owl:annotatedTarget "Reduced NK cell number" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50103 ; owl:annotatedTarget "excitatory amino acid receptor agonist" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040219 ; owl:annotatedTarget "Lack of natural killer cells, a type of lymphocyte in the innate immune system that contains cytoplasmic granzymes, i.e., small granules with perforin and proteases that allow natural killer cells to form pores in the cell membrane of the target cell through which the granzymes and associated molecules can enter, inducing apoptosis." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040219 ; owl:annotatedTarget "Absent NK cells" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50103 ; owl:annotatedTarget "excitatory amino acid receptor agonists" . [] oboInOwl:hasDbXref , "PMID:25401392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040222 ; owl:annotatedTarget "An increased tendency towards thrombosis in the mother during a pregnancy." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "Geschlechtshormon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "Geschlechtshormone" . [] oboInOwl:hasDbXref "PMID:16473816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040223 ; owl:annotatedTarget "Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040223 ; owl:annotatedTarget "Intrapulmonary haemorrhage" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040223 ; owl:annotatedTarget "Pulmonary haemorrhage" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "Sexualhormon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "Sexualhormone" . [] oboInOwl:hasDbXref "PMID:27231694" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040242 ; owl:annotatedTarget "Bleeding occuring within a muscle" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040242 ; owl:annotatedTarget "Muscle haemorrhage" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040251 ; owl:annotatedTarget "A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the hand." . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040251 ; owl:annotatedTarget "Hand dimples" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "hormone sexuelle" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "hormones sexuelles" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:2303428" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50112 ; owl:annotatedTarget "sex hormones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "Androgen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040257 ; owl:annotatedTarget "A deviation in the size of nasopharyngeal adenoids." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "Androgene" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "androgene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040259 ; owl:annotatedTarget "Absence of the nasopharyngeal adenoids as a developmental defect." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "androgenes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040260 ; owl:annotatedTarget "An abnormal decrease in the size of nasopharyngeal adenoids." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040264 ; owl:annotatedTarget "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040264 ; owl:annotatedTarget "Jaw pain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "androgeno" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040268 ; owl:annotatedTarget "Increased susceptibility to middle ear infections, as manifested by recurrent episodes of middle ear infections" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "androgenos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040270 ; owl:annotatedTarget "An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040272 ; owl:annotatedTarget "A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord." . [] oboInOwl:hasDbXref "PMID:19527360" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0040272 ; owl:annotatedTarget "Seen in a wide-ranging variety of spinal cord processes including; simple MR artefacts, congenital anomalies etc. Characterization of the abnormal areas of T2 signal as well as their appearance on other MR imaging sequences, when combined with clinical context and laboratory investigations, will often allow a unique diagnosis, or at least aid in narrowing the differential diagnosis." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50113 ; owl:annotatedTarget "androgens" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "Estrogene" . [] oboInOwl:hasDbXref "PMID:25874832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040288 ; owl:annotatedTarget "The condition of inability to eat normally treated by placement of a thin tube through the nose into the stomach that is then used to carry food." . [] oboInOwl:hasDbXref "https://rarediseases.info.nih.gov/diseases/6229/cyclic-neutropenia" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040289 ; owl:annotatedTarget "Recurrent episodes of abnormally low levels of neutrophils in the body (neutropenia)." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040289 ; owl:annotatedTarget "CyN" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "Oestrogen" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:2448252" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "Oestrogene" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogene" . [] oboInOwl:hasDbXref "PMID:24427573" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040297 ; owl:annotatedTarget "Preauricular sinus is an occasional finding and most frequently appears as a small pit close to the anterior margin of the ascending portion of the helix. The opening has also been reported along the postero superior margin of the helix, the tragus or the lobule. Preauricular sinus may lead to the formation of a subcutaneous cyst that is intimately related to the tragal cartilage and the anterior crus of the helix." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogenes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogenes Hormon" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogeno" . [] oboInOwl:hasDbXref "PMID:23415440" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040302 ; owl:annotatedTarget "Increased concentration of glycerol in the blood." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogenos" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "estrogens" . [] oboInOwl:hasDbXref "PMID:29532805" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040307 ; owl:annotatedTarget "A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "oestrogen" . [] oboInOwl:hasDbXref "PMID:31657698" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040311 ; owl:annotatedTarget "Polyarthritis refers to a joint disease that involves at least five joints. One or more signs of inflammation, including pain, movement restriction, swelling, warmth, and redness, are seen in the joints involved. Polyarthritis is defined as symmetric if at least half of the joints involved are affected in a symmetric (i.e., both right and the left) fashion." . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040312 ; owl:annotatedTarget "Arthritis of temporomandibular joint" . [] oboInOwl:hasDbXref "PMID:14760812" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040313 ; owl:annotatedTarget "A type of arthritis that affects up to four joints in the first six months of disease." . [] oboInOwl:hasDbXref , "PMID:23730041", "PMID:29768628" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040314 ; owl:annotatedTarget "The vagina ends in a blind pouch or sac rather than being connected to the internal genitalia." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "oestrogene" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040315 ; owl:annotatedTarget "Tongue oedema" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "oestrogenes" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:2449247" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50114 ; owl:annotatedTarget "oestrogens" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040323 ; owl:annotatedTarget "Erythema of the eyelids" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0040323 ; owl:annotatedTarget "Red eyelid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040326 ; owl:annotatedTarget "Underdevelopment of the olfactory bulb." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040327 ; owl:annotatedTarget "An abnormal morphology of the olfactory bulb (bulbus olfactorius), which is involved in olfaction, i.e. the sense of smell." . [] oboInOwl:hasDbXref "PMID:25636970" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0040330 ; owl:annotatedTarget "Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together." . [] oboInOwl:hasDbXref "PMID:6155073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041042 ; owl:annotatedTarget "The absence of lactoferrin in neutrophil granules, which could be caused by either an isolated failure of synthesis of this protein (or the production of an antigenically unrecognizable form of lactoferrin) or a complete deficiency of specific granule production." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50160 ; owl:annotatedTarget "steroid acid anions" . [] oboInOwl:hasDbXref "PMID:3460353" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041043 ; owl:annotatedTarget "An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50177 ; owl:annotatedTarget "dermatologic agent" . [] oboInOwl:hasDbXref "PMID:46759" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041044 ; owl:annotatedTarget "An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme." . [] oboInOwl:hasDbXref "PMID:6155073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041045 ; owl:annotatedTarget "An increased number of mitochondria detected in neutrophils." . [] oboInOwl:hasDbXref "PMID:6155073" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041046 ; owl:annotatedTarget "An increased number of ribosomes detected in neutrophils." . [] oboInOwl:hasDbXref "PMID:16986027" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041047 ; owl:annotatedTarget "A compression or resistance upon the bladder outflow channel at any location from the bladder neck to urethral meatus, which usually causes lower urinary tract symptoms (LUTS)." . [] oboInOwl:hasDbXref "PMID:26293662" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041048 ; owl:annotatedTarget "A decrease in the protein expression of GPI-anchor proteins, such as CD55 and CD59, at the cell surface, which suggests a defect in GPI-anchor biosynthesis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041049 ; owl:annotatedTarget "An inability to digest starch." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50177 ; owl:annotatedTarget "dermatologic drugs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0041049 ; owl:annotatedTarget "Starch intolerance" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50177 ; owl:annotatedTarget "dermatological agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041050 ; owl:annotatedTarget "Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells." . [] oboInOwl:hasDbXref "https://www.ncbi.nlm.nih.gov/books/NBK549775/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041051 ; owl:annotatedTarget "A rare condition that is characterized by a complete loss of taste function of the tongue." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0041051 ; owl:annotatedTarget "Lost taste" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50188 ; owl:annotatedTarget "provitamins" . [] oboInOwl:hasDbXref "PMID:31412107" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041052 ; owl:annotatedTarget "A developmental defect characterized by the absence of the putamen owing to its failure to develop." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50248 ; owl:annotatedTarget "hematologic agents" . [] oboInOwl:hasDbXref "PMID:25886304", "PMID:29089832" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041056 ; owl:annotatedTarget "A cruciform-shaped hyperintensity within the pons found on T2-weighted magnetic resonance imaging (MRI)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50249 ; owl:annotatedTarget "anticoagulante" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50249 ; owl:annotatedTarget "anticoagulants" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:2714813" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50263 ; owl:annotatedTarget "2-Hydroxydicarboxylic acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50263 ; owl:annotatedTarget "2-hydroxydicarboxylic acids" . [] oboInOwl:hasDbXref , "http://pennshape.upenn.edu/" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041079 ; owl:annotatedTarget "The percentage of fat as a part of total body weight below the norm, usually defined as less than 14% for females and less than 8% for males." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:23993918" . [] oboInOwl:hasDbXref "PMID:31570879" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041080 ; owl:annotatedTarget "A deviation from the normal proportion of exhausted T cell relative to T cell in the blood." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:23998799" . [] oboInOwl:hasDbXref "PMID:20109361" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041081 ; owl:annotatedTarget "Bone fracture anywhere in the tibia, fibula, or ankle." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:24329110" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:24628402" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:24709544" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25144792" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25157234" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:2775195" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25269430" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25391982" . [] oboInOwl:hasDbXref "PMID:23250816" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041092 ; owl:annotatedTarget "Heightened emotional reactivity to environmental stimuli, including emotions of others." . [] oboInOwl:hasDbXref "ISBN:0-07-138076-0", "PMID:26475537", "PMID:29593008", "PMID:32900765" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041093 ; owl:annotatedTarget "A nail dystrophy that is preseents as grooved lines that run from side to side on the fingernail or the toenail that may look like indentations or ridges on the nail plate. They are caused by temporary disruption in the growth of proximal nail matrix. Trauma is usually the initiating factor such as infections, severe medical illnesses, major surgery/anesthesia, medication side effects, and autoimmune disease." . [] oboInOwl:hasDbXref "PMID:31215789" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041094 ; owl:annotatedTarget "Continuous or nearly continuous configuration of the cartilaginous tracheal ring." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0041094 ; owl:annotatedTarget "CTRD" . [] oboInOwl:hasSynonymType hp:plural_form ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0041094 ; owl:annotatedTarget "Complete tracheal rings" . [] oboInOwl:hasDbXref "PMID:23456797" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041095 ; owl:annotatedTarget "Abnormally reduced blood flow pulsatility in in the middle cerebral artery (MCA). The pulsatility index (PI) is calculated using the following equation PI = (peak systolic velocity-end-diastolic velocity)/mean velocity." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25591121" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25620096" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:25795057" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:26028253" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:26184144" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28070577" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28215138" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28219047" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:3392043" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28259775" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28319647" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28329729" . [] oboInOwl:hasDbXref "https://www.hss.edu/condition-list_ankle-fractures.asp" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041153 ; owl:annotatedTarget "A fracture or multiple fractures of one or more of three bones in the ankle joint: the tibia (shinbone), the fibula (outer ankle bone), and the talus (which is the bone that connects your leg to your foot)." . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "PMID:28334528" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50266 ; owl:annotatedTarget "Prodrugs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50267 ; owl:annotatedTarget "chemoprotectant" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50267 ; owl:annotatedTarget "chemoprotectants" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50267 ; owl:annotatedTarget "chemoprotective agent" . [] oboInOwl:hasDbXref "PMID:30847497" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041162 ; owl:annotatedTarget "A partial or complete breakage of a metatarsal bone." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50267 ; owl:annotatedTarget "chemoprotective agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50267 ; owl:annotatedTarget "protective agents" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:3864442" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50313 ; owl:annotatedTarget "onium cations" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50313 ; owl:annotatedTarget "onium cations" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50313 ; owl:annotatedTarget "onium ion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50313 ; owl:annotatedTarget "onium ions" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_50315 ; owl:annotatedTarget "Gmelin:331" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50315 ; owl:annotatedTarget "chloranium" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50315 ; owl:annotatedTarget "chloronium" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50315 ; owl:annotatedTarget "H2Cl(+)" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50315 ; owl:annotatedTarget "[ClH2](+)" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:7534889" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50325 ; owl:annotatedTarget "canonical amino-acid side-chain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50325 ; owl:annotatedTarget "canonical amino-acid side-chains" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50325 ; owl:annotatedTarget "proteinogenic amino-acid side-chain" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50325 ; owl:annotatedTarget "proteinogenic amino-acid side-chain groups" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50325 ; owl:annotatedTarget "proteinogenic amino-acid side-chains" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50326 ; owl:annotatedTarget "sulfanylmethyl" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50326 ; owl:annotatedTarget "-CH2-SH" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50326 ; owl:annotatedTarget "HS-CH2-" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50326 ; owl:annotatedTarget "cysteine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50329 ; owl:annotatedTarget "2-carboxyethyl" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:7693874" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50329 ; owl:annotatedTarget "glutamic acid side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50330 ; owl:annotatedTarget "2-amino-2-oxoethyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50330 ; owl:annotatedTarget "asparagine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50331 ; owl:annotatedTarget "3-amino-3-oxopropyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50331 ; owl:annotatedTarget "glutamine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50336 ; owl:annotatedTarget "4-hydroxybenzyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50336 ; owl:annotatedTarget "tyrosine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50337 ; owl:annotatedTarget "1H-indol-3-ylmethyl" . [] oboInOwl:hasDbXref "https://my.clevelandclinic.org/health/diseases/17470-shoulder-fractures#:~:text=Trauma%20may%20cause%20a%20fracture,of%20arthritis%20if%20left%20alone." ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0041217 ; owl:annotatedTarget "A fracture or multiple fractures of the humerus (ball) or the glenoid (socket) of the shoulder joint." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50337 ; owl:annotatedTarget "tryptophan side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50338 ; owl:annotatedTarget "1H-imidazol-4-ylmethyl" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:8448384" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50338 ; owl:annotatedTarget "histidine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50339 ; owl:annotatedTarget "4-aminobutyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50339 ; owl:annotatedTarget "lysine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50340 ; owl:annotatedTarget "3-carbamimidamidopropyl" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50340 ; owl:annotatedTarget "3-(carbamimidoylamino)propyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50340 ; owl:annotatedTarget "3-guanidinopropyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50340 ; owl:annotatedTarget "arginine side-chain" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50341 ; owl:annotatedTarget "1-hydroxyethyl" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50341 ; owl:annotatedTarget "threonine side-chain" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:8496625" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50401 ; owl:annotatedTarget "cholestanoids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50402 ; owl:annotatedTarget "androstanoids" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "aperient" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "aperients" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "laxante" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "laxatives" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "purgative" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50503 ; owl:annotatedTarget "purgatives" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "PMID:9375803" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50505 ; owl:annotatedTarget "sweetener" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50505 ; owl:annotatedTarget "sweeteners" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50513 ; owl:annotatedTarget "mydriatics" . [] oboInOwl:hasDbXref , "PMID:19808787" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045005 ; owl:annotatedTarget "A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50584 ; owl:annotatedTarget "alkyl alcohols" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045006 ; owl:annotatedTarget "Aplasia (absence) of the lymphatic vessels." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045006 ; owl:annotatedTarget "Absent lymphatic vessels" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50584 ; owl:annotatedTarget "hydroxyalkane" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50584 ; owl:annotatedTarget "hydroxyalkanes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteopenia agent" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045011 ; owl:annotatedTarget "Decreased urine HCO3 concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteopenia agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteopenia drug" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045018 ; owl:annotatedTarget "Partial double eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045018 ; owl:annotatedTarget "Partial duplication of eyebrows" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteopenia drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045025 ; owl:annotatedTarget "Reduction in the vertical distance between the upper and lower eyelids." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045025 ; owl:annotatedTarget "Small opening between the eyelids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045025 ; owl:annotatedTarget "Small palpebral fissures" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasNarrowSynonym ; owl:annotatedSource obo:HP_0045025 ; owl:annotatedTarget "Decreased size of palpebral fissure" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "(2S,3R,4E)-2-(acylamino)-3-hydroxyoctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporosis agent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0045025 ; owl:annotatedTarget "Narrow eyelid opening" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporosis agents" . [] oboInOwl:hasDbXref "PMID:8779318" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045028 ; owl:annotatedTarget "Severe microcephaly and lissencephaly with granular surfaces with immature cortical plate, reduced in thickness, with focal polymicrogyria and immature small neurons with rare processes, intermingled with a considerable number of glial elements." . [] oboInOwl:hasDbXref "https://medlineplus.gov/ency/article/000447.htm" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045029 ; owl:annotatedTarget "Inflammation and thickening (localized fibrosis) of the fascia, the tissue under the skin and over the muscle, typically associated with a build up of eosinophils in the muscles and tissues." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporosis drug" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporosis drugs" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045035 ; owl:annotatedTarget "Decreased urinary copper concentration" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotic" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotic agent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045036 ; owl:annotatedTarget "Abnormal urinary copper concentration" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045037 ; owl:annotatedTarget "Abnormality of jaw muscles" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotic agents" . [] oboInOwl:hasDbXref "PMID:25984930" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045040 ; owl:annotatedTarget "A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate." . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045042 ; owl:annotatedTarget "Concentration of the complement component C4 in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045043 ; owl:annotatedTarget "Concentration of the complement component C4a in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "https://emedicine.medscape.com/article/135478-overview" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045044 ; owl:annotatedTarget "Concentration of the complement component C4b in the blood circulation below the lower limit of normal." . [] oboInOwl:hasDbXref "wikipedia" ; a owl:Axiom ; owl:annotatedProperty rdfs:comment ; owl:annotatedSource obo:HP_0045046 ; owl:annotatedTarget "Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene." . [] oboInOwl:hasDbXref , "PMID:34406727", "PMID:3953566" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045047 ; owl:annotatedTarget "Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045047 ; owl:annotatedTarget "HbS haemoglobin" . [] oboInOwl:hasDbXref , "PMID:26372049" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045048 ; owl:annotatedTarget "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045048 ; owl:annotatedTarget "Increased HbA2 haemoglobin" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045048 ; owl:annotatedTarget "Increased haemoglobin A2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotic drug" . [] oboInOwl:hasDbXref "PMID:32310609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045049 ; owl:annotatedTarget "An abnormal amount of oxygen passes into the blood from the lungs and/or an abnormal amount of carbon dioxide passes from the blood into the lungs." . [] oboInOwl:hasDbXref "PMID:32310609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045050 ; owl:annotatedTarget "Increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test." . [] oboInOwl:hasDbXref "PMID:32310609" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045051 ; owl:annotatedTarget "Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotic drugs" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "anti-osteoporotics" . [] oboInOwl:hasDbXref "PMID:15692466" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045055 ; owl:annotatedTarget "An abnormal appearance of hair under polarizing microscopy (using crossed polarizers), whereby hair shafts show striking alternating bright and dark bands, often referred to as tiger tail banding." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045055 ; owl:annotatedTarget "Tiger tail banding" . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "(Gal)1 (Glc)1 (Neu5Ac)1 (Cer)1" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "antiosteoporotic" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "antiosteoporotics" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "bone density conservation agents" . [] oboInOwl:hasDbXref "PMID:3632007" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045059 ; owl:annotatedTarget "A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point that is composed of localized hyperkeratosis (the latter may be demonstrated histopathologically)." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "bone density conservation drug" . [] oboInOwl:hasDbXref , "PMID:12717392" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045063 ; owl:annotatedTarget "Des-gamma carboxyprothrombin (DCP) or pro-thrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of patients with HCC. Generation of DCP is thought to be a result of an acquired defect in the post- translational carboxylation of the prothrombin precursor in malignant cells." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50646 ; owl:annotatedTarget "bone density conservation drugs" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045073 ; owl:annotatedTarget "Inflammation in any serous cavity." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50689 ; owl:annotatedTarget "reproductive control agent" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045074 ; owl:annotatedTarget "Thin eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045074 ; owl:annotatedTarget "Thin eyebrows" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50689 ; owl:annotatedTarget "reproductive control drugs" . [] oboInOwl:hasDbXref , "PMID:19125427" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045075 ; owl:annotatedTarget "Decreased density/number of eyebrow hairs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045075 ; owl:annotatedTarget "Hypotrichosis of eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045075 ; owl:annotatedTarget "Sparse eyebrow" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045075 ; owl:annotatedTarget "Sparse eyebrows" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "Oligosaccharide" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045081 ; owl:annotatedTarget "Abnormal BMI" . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045082 ; owl:annotatedTarget "Decreased BMI" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "oligosaccharides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "O-glycosylglycoside" . [] oboInOwl:hasDbXref , "PMID:28599980" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0045086 ; owl:annotatedTarget "The ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees)." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0045086 ; owl:annotatedTarget "Knee joint over-flexibility" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "(N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "O-glycosylglycosides" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100000 ; owl:annotatedTarget "An early onset of puberty, in this case early does not refer to precocious." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "oligosacarido" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100000 ; owl:annotatedTarget "Early onset of sexual maturation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100001 ; owl:annotatedTarget "Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100002 ; owl:annotatedTarget "A malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100003 ; owl:annotatedTarget "A Malignant mesothelioma originating from cells of the peritoneum (the thin layer of mesothelium lining the abdomen). Peritoneal mesothelioma is the second most common form of mesothelioma after pleural mesothelioma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100004 ; owl:annotatedTarget "A Malignant mesothelioma originating from cells of the pericardium (the thin layer of mesothelium lining the heart)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100005 ; owl:annotatedTarget "A Malignant mesothelioma of the testis." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100006 ; owl:annotatedTarget "A neoplasm of the central nervous system." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100006 ; owl:annotatedTarget "Neoplasm of the CNS" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100006 ; owl:annotatedTarget "Tumors of the central nervous system" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100006 ; owl:annotatedTarget "Tumours of the central nervous system" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50699 ; owl:annotatedTarget "oligosacaridos" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100007 ; owl:annotatedTarget "A benign or malignant neoplasm (tumor) of the peripheral nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100007 ; owl:annotatedTarget "Tumor of the peripheral nervous system" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100007 ; owl:annotatedTarget "Tumour of the peripheral nervous system" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100008 ; owl:annotatedTarget "A benign nerve sheath tumor composed of Schwann cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100008 ; owl:annotatedTarget "Schwannomas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100012 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the eye." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100012 ; owl:annotatedTarget "Eye tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100012 ; owl:annotatedTarget "Eye tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100013 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the breast." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100013 ; owl:annotatedTarget "Breast tumor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50733 ; owl:annotatedTarget "Dietary Supplement" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100013 ; owl:annotatedTarget "Breast tumour" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100013 ; owl:annotatedTarget "Tumours of the breast" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100014 ; owl:annotatedTarget "An epiretinal membrane is a thin sheet of fibrous tissue that can develop on the surface of the macular area of the retina and cause a disturbance in vision. An epiretinal membrane area can develop on the thin macular area of the retin. An epiretinal membrane is also sometimes called a macular pucker, premacular fibrosis, surface wrinkling retinopathy or cellophane maculopathy." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100014 ; owl:annotatedTarget "Epiretinal membranes" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50733 ; owl:annotatedTarget "Food Supplementation" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100015 ; owl:annotatedTarget "The presence of a supernumerary, i.e. third, crus of the helix in the helix, arising at or above the normal bifurcation of the antihelix." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50733 ; owl:annotatedTarget "Nutritional supplement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100016 ; owl:annotatedTarget "Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100017 ; owl:annotatedTarget "A cataract that affects the capsule of the lens." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100018 ; owl:annotatedTarget "A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100018 ; owl:annotatedTarget "Yellowish cloudy center of lens" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100018 ; owl:annotatedTarget "Yellowish cloudy centre of lens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100019 ; owl:annotatedTarget "A cataract which affects the layer of the lens surrounding the nucleus, i.e., the lens cortex. It is identified by its unique wedge or spoke appearance." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100020 ; owl:annotatedTarget "A cataract which is found in the back outer layer of the lens. This type often develops more rapidly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100021 ; owl:annotatedTarget "Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behaviour, by epilepsy, and by secondary musculoskeletal problems." . [] oboInOwl:hasSynonymType hp:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100021 ; owl:annotatedTarget "CP" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100022 ; owl:annotatedTarget "An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements." . [] oboInOwl:source "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_507393 ; owl:annotatedTarget "PMID:17765547" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100022 ; owl:annotatedTarget "Abnormality of movement" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100022 ; owl:annotatedTarget "Movement disorder" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100022 ; owl:annotatedTarget "Unusual movement" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100024 ; owl:annotatedTarget "An unusually happy aspect over time which can also may be observed during inappropriate situations that should be causing for example distress, fear or anger." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_507393 ; owl:annotatedTarget "2-azaniumylethane-1-sulfonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100026 ; owl:annotatedTarget "An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100027 ; owl:annotatedTarget "A recurrent form of pancreatitis." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100027 ; owl:annotatedTarget "Recurring pancreas inflammation" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_507393 ; owl:annotatedTarget "2-ammonioethanesulfonate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Mislocalised thyroid gland." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Aberrant thyroid" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Aberrant thyroid gland" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Abnormal thryoid location" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Ectopic thyroid gland" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "(Neu5Ac)GM3" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_507393 ; owl:annotatedTarget "taurine" . [] oboInOwl:hasDbXref , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100028 ; owl:annotatedTarget "Heteropic thyroid gland" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100029 ; owl:annotatedTarget "An aberrant thyroid gland or Ectopic thyroid located at the base of the tongue, just posterior to the foramen cecum as a result of a failure of the thyroid to descend." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100030 ; owl:annotatedTarget "Accessory ectopic thyroid tissue arising from remnants of the thyroglossal duct anywhere along the path of the thyroglossal duct tract." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100031 ; owl:annotatedTarget "A tumor (abnormal growth of tissue) of the thyroid gland." . [] oboInOwl:hasDbXref "PMID:20589866" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100033 ; owl:annotatedTarget "Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppressible and are usually associated with awareness of an urge to perform the movement." . [] oboInOwl:hasDbXref , , , , ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100033 ; owl:annotatedTarget "Tic disorder" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100035 ; owl:annotatedTarget "Verbal tics" . [] oboInOwl:hasDbXref , , , , ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100035 ; owl:annotatedTarget "Vocal tics" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100036 ; owl:annotatedTarget "A band of bone material of decreased density forming alongside the surface of the cortical bone with thickening of the periosteum. Callus formation in the affected area is common and gives the appearance of a false fracture." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50745 ; owl:annotatedTarget "gestagen" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50745 ; owl:annotatedTarget "gestagens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100037 ; owl:annotatedTarget "An abnormality of the hair of head." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100037 ; owl:annotatedTarget "Abnormality of the scalp hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100038 ; owl:annotatedTarget "Scalp hair whose growth is slower than normal." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100038 ; owl:annotatedTarget "Slow-growing scalp hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100039 ; owl:annotatedTarget "An Abnormality of cortical bone leading to an abnormal thickness of the cortex of affected bones." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50745 ; owl:annotatedTarget "progestagen" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100040 ; owl:annotatedTarget "A broad appearance of the second toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100040 ; owl:annotatedTarget "Wide 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50745 ; owl:annotatedTarget "progestagens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100041 ; owl:annotatedTarget "A broad appearance of the third toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100041 ; owl:annotatedTarget "Broad 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100041 ; owl:annotatedTarget "Wide 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50745 ; owl:annotatedTarget "progestogens" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100042 ; owl:annotatedTarget "A broad appearance of the fourth toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100042 ; owl:annotatedTarget "Broad 4th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100042 ; owl:annotatedTarget "Wide 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50748 ; owl:annotatedTarget "antipsoriatic agent" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100043 ; owl:annotatedTarget "A broad appearance of the fifth toe." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100043 ; owl:annotatedTarget "Broad 5th toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100043 ; owl:annotatedTarget "Broad little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100043 ; owl:annotatedTarget "Broad pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100043 ; owl:annotatedTarget "Broad pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50748 ; owl:annotatedTarget "antipsoriatic drug" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100044 ; owl:annotatedTarget "Absent end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50846 ; owl:annotatedTarget "Biomodulator" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100045 ; owl:annotatedTarget "Bracket shaped end part of 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50846 ; owl:annotatedTarget "Immune factor" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "GM3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50846 ; owl:annotatedTarget "Immunologic factor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100046 ; owl:annotatedTarget "Cone-shaped end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50846 ; owl:annotatedTarget "Immunological factor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100047 ; owl:annotatedTarget "Enlarged end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50846 ; owl:annotatedTarget "immunomodulators" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100048 ; owl:annotatedTarget "Fragmentation of the end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50857 ; owl:annotatedTarget "anti-allergic agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100049 ; owl:annotatedTarget "Irregular end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50857 ; owl:annotatedTarget "anti-allergic drug" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100050 ; owl:annotatedTarget "Epiphyses of the 2nd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50857 ; owl:annotatedTarget "anti-allergic drugs" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100050 ; owl:annotatedTarget "Increased bone density of end part of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50858 ; owl:annotatedTarget "corticoides" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100052 ; owl:annotatedTarget "Small end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50858 ; owl:annotatedTarget "corticosteroides" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50858 ; owl:annotatedTarget "corticosteroids" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100053 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100053 ; owl:annotatedTarget "Speckled calcifications in the end part of the 2nd toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100054 ; owl:annotatedTarget "Triangular end part of the 2nd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "GM3 (NeuAc)" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50860 ; owl:annotatedTarget "organic compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100055 ; owl:annotatedTarget "Absent end part of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50860 ; owl:annotatedTarget "organic entity" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100056 ; owl:annotatedTarget "Bracket shaped end part of 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50860 ; owl:annotatedTarget "organic molecular entities" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "agente carcinogeno" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100057 ; owl:annotatedTarget "Cone-shaped end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "cancerigene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100058 ; owl:annotatedTarget "Enlarged end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "cancerogene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100059 ; owl:annotatedTarget "Fragmentation of the end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "carcinogen" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100060 ; owl:annotatedTarget "Irregular end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "carcinogene" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100061 ; owl:annotatedTarget "Epiphyses of the 3rd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100061 ; owl:annotatedTarget "Increased bone density of end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "carcinogenic agents" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "carcinogeno" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100063 ; owl:annotatedTarget "Small end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "Hematoside" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50903 ; owl:annotatedTarget "carcinogens" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50904 ; owl:annotatedTarget "alergeno" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100064 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100064 ; owl:annotatedTarget "Speckled calcifications in the end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50904 ; owl:annotatedTarget "allergene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100065 ; owl:annotatedTarget "Triangular end part of the 3rd toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50904 ; owl:annotatedTarget "allergenic agent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100066 ; owl:annotatedTarget "Absent end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "agente neurotoxico" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100067 ; owl:annotatedTarget "Bracket shaped end part of 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "nerve poison" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100068 ; owl:annotatedTarget "Cone-shaped end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "nerve poisons" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "neurotoxic agent" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100069 ; owl:annotatedTarget "Enlarged end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "neurotoxic agents" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100070 ; owl:annotatedTarget "Fragmentation of the end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "neurotoxicant" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100071 ; owl:annotatedTarget "Irregular end part of the 4th toe bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "N-Acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50910 ; owl:annotatedTarget "neurotoxins" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100072 ; owl:annotatedTarget "Epiphyses of the 4th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100072 ; owl:annotatedTarget "Increased bone density of end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50967 ; owl:annotatedTarget "non-covalently-bound molecular entities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100074 ; owl:annotatedTarget "Small end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50994 ; owl:annotatedTarget "primary amino compounds" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100075 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100075 ; owl:annotatedTarget "Speckled calcifications in the end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_50996 ; owl:annotatedTarget "tertiary amino compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100076 ; owl:annotatedTarget "Triangular end part of the 4th toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51061 ; owl:annotatedTarget "hormone receptor modulators" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100077 ; owl:annotatedTarget "Absent end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100077 ; owl:annotatedTarget "Absent end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100077 ; owl:annotatedTarget "Absent end part of the pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100078 ; owl:annotatedTarget "Bracket shaped end part of little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100078 ; owl:annotatedTarget "Bracket shaped end part of pinkie toe bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51143 ; owl:annotatedTarget "Nitrogenous compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100078 ; owl:annotatedTarget "Bracket shaped end part of pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51143 ; owl:annotatedTarget "nitrogen compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100079 ; owl:annotatedTarget "Cone-shaped end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100079 ; owl:annotatedTarget "Cone-shaped end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100079 ; owl:annotatedTarget "Cone-shaped end part of the pinky toe bone" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "Neu5Ac-alpha2->3Gal-beta1->4Glc-beta1->1'Cer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51143 ; owl:annotatedTarget "nitrogen molecular entities" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100080 ; owl:annotatedTarget "Enlarged end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100080 ; owl:annotatedTarget "Enlarged end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100080 ; owl:annotatedTarget "Enlarged end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51151 ; owl:annotatedTarget "dipolar compounds" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51422 ; owl:annotatedTarget "organodiyl groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100081 ; owl:annotatedTarget "Fragmentation of the end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100081 ; owl:annotatedTarget "Fragmentation of the end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100081 ; owl:annotatedTarget "Fragmentation of the end part of the pinky toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100082 ; owl:annotatedTarget "Irregular end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100082 ; owl:annotatedTarget "Irregular end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100082 ; owl:annotatedTarget "Irregular end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acyl amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100083 ; owl:annotatedTarget "Epiphyses of the 5th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100083 ; owl:annotatedTarget "Increased bone density of end part of the little toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acyl amino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100083 ; owl:annotatedTarget "Increased bone density of end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100083 ; owl:annotatedTarget "Increased bone density of end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acyl-amino-acid" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acyl-amino-acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100085 ; owl:annotatedTarget "Small end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100085 ; owl:annotatedTarget "Small end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100085 ; owl:annotatedTarget "Small end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acylamino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100086 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100086 ; owl:annotatedTarget "Speckled calcifications in the end part of the little toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100086 ; owl:annotatedTarget "Speckled calcifications in the end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100086 ; owl:annotatedTarget "Speckled calcifications in the end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "N-acylamino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100087 ; owl:annotatedTarget "Triangular end part of the little toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "Neu5Acalpha2->3Galbeta1->4Glcbeta-Cer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "acyl-amino-acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100087 ; owl:annotatedTarget "Triangular end part of the pinkie toe bone" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100087 ; owl:annotatedTarget "Triangular end part of the pinky toe bone" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "acyl-amino-acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100088 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51569 ; owl:annotatedTarget "acylamino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100089 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51683 ; owl:annotatedTarget "methoxybenzene" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100090 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51689 ; owl:annotatedTarget "enones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100091 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51721 ; owl:annotatedTarget "alpha,beta-unsaturated ketones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_51958 ; owl:annotatedTarget "organic polycyclic compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100092 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100093 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100094 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_52090 ; owl:annotatedTarget "Reaxys:1839368" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100095 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "NeuAc-GM3" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52090 ; owl:annotatedTarget "methoxide ion" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100096 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52209 ; owl:annotatedTarget "etiopathogenetic agent" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52209 ; owl:annotatedTarget "etiopathogenetic role" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100097 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100097 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100097 ; owl:annotatedTarget "Abnormality of the end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52214 ; owl:annotatedTarget "ligands" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100098 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100098 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100098 ; owl:annotatedTarget "Abnormality of the end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52215 ; owl:annotatedTarget "photochemical roles" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100099 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52217 ; owl:annotatedTarget "farmaco" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100099 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100099 ; owl:annotatedTarget "Abnormality of the end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52217 ; owl:annotatedTarget "medicament" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100100 ; owl:annotatedTarget "Absent end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52217 ; owl:annotatedTarget "pharmaceuticals" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100101 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52254 ; owl:annotatedTarget "hydroxyapatite" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100102 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52290 ; owl:annotatedTarget "mitogens" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100103 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "NeuAcalpha2-3Galbeta1-4Glcbeta1-1'Cer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52395 ; owl:annotatedTarget "oxyketones" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52396 ; owl:annotatedTarget "alpha-oxyketones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100104 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "EC 3.2.1.* (glycosidase) inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100105 ; owl:annotatedTarget "Irregular end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "EC 3.2.1.* inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100106 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "EC 3.2.1.* inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "glycosidase (EC 3.2.1.*) inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100108 ; owl:annotatedTarget "Small end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "glycosidase (EC 3.2.1.*) inhibitors" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100109 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100109 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "glycosidase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100110 ; owl:annotatedTarget "Triangular end part of the outermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "glycosidase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52424 ; owl:annotatedTarget "glycoside hydrolase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100111 ; owl:annotatedTarget "Absent end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "NeuAcalpha2->3Galbeta1->4Glc-Cer" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "EC 3.2.1.18 (exo-alpha-sialidase) inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100112 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "EC 3.2.1.18 inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100113 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "EC 3.2.1.18 inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100114 ; owl:annotatedTarget "Enlarged end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "N-acylneuraminate glycohydrolase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100115 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "N-acylneuraminate glycohydrolase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "acetylneuraminidase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100116 ; owl:annotatedTarget "Irregular end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "acetylneuraminidase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100117 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "acetylneuraminyl hydrolase inhibitor" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "acetylneuraminyl hydrolase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100119 ; owl:annotatedTarget "Small end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "alpha-neuraminidase inhibitor" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100120 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100120 ; owl:annotatedTarget "Speckled calcifications in of the end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "alpha-neuraminidase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100121 ; owl:annotatedTarget "Triangular end part of the middle bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "exo-alpha-sialidase (EC 3.2.1.18) inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100122 ; owl:annotatedTarget "Absent end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "exo-alpha-sialidase (EC 3.2.1.18) inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "exo-alpha-sialidase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100123 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "exo-alpha-sialidase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100124 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "neuraminidase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100125 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "neuraminidase inhibitors" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100126 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "sialidase inhibitor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100127 ; owl:annotatedTarget "Irregular end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52425 ; owl:annotatedTarget "sialidase inhibitors" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_52845 ; owl:annotatedTarget "cyclic organic groups" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100128 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53000 ; owl:annotatedTarget "antigenic determinant" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53000 ; owl:annotatedTarget "epitope function" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100130 ; owl:annotatedTarget "Small end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53000 ; owl:annotatedTarget "epitope role" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100131 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 2nd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100131 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53291 ; owl:annotatedTarget "2-halophenols" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100132 ; owl:annotatedTarget "Triangular end part of the innermost bone of the 2nd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100133 ; owl:annotatedTarget "Abnormality of the growth of the pubic hair. Pubic hair is part of the secondary sexual hair, which normally ensues during puberty." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100133 ; owl:annotatedTarget "Abnormality of the pubic hair" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100134 ; owl:annotatedTarget "Abnormality of the growth of the axillary hair. Axillary hair is part of the secondary sexual hair, which normally ensues during puberty." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_533015 ; owl:annotatedTarget "(2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100135 ; owl:annotatedTarget "Absent end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEMBL" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_533015 ; owl:annotatedTarget "(S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100136 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_533015 ; owl:annotatedTarget "3,3',5-triiodo-L-thyronine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100137 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53309 ; owl:annotatedTarget "polyanion" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramides" . [] oboInOwl:hasDbXref "SUBMITTER" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53309 ; owl:annotatedTarget "polyanions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100138 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53368 ; owl:annotatedTarget "ionic polymer" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100139 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_53368 ; owl:annotatedTarget "polyionic macromolecule" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100140 ; owl:annotatedTarget "Irregular end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_5386 ; owl:annotatedTarget "Globin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100141 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5386 ; owl:annotatedTarget "globins" . [] oboInOwl:hasDbXref "COMe" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5386 ; owl:annotatedTarget "pentacoordinate globin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100143 ; owl:annotatedTarget "Small end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100144 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100144 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100145 ; owl:annotatedTarget "Triangular end part of the outermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100146 ; owl:annotatedTarget "Absent end part of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "CAS:306-08-1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100147 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of 3rd toe" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "CAS:306-08-1" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100148 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "PMID:14688447" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100149 ; owl:annotatedTarget "Enlarged end part of the middle bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "PMID:24007816" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "PMID:24416192" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100150 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "PMID:24423636" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100151 ; owl:annotatedTarget "Irregular end part of the middle bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "PMID:8353435" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100152 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the 3rd toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "Reaxys:2213447" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "2-(4-hydroxy-3-methoxyphenyl)acetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100154 ; owl:annotatedTarget "Small end part of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "Homovanillic acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100155 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100155 ; owl:annotatedTarget "Speckled calcifications in the end part of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "(4-hydroxy-3-methoxyphenyl)acetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100156 ; owl:annotatedTarget "Triangular end part of the middle bone of the 3rd toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "3-Methoxy-4-hydroxyphenylacetate" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "3-Methoxy-4-hydroxyphenylacetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100157 ; owl:annotatedTarget "Absent end part of the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "4-Hydroxy-3-methoxybenzeneacetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100158 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of 3rd toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "HVA" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100159 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_545959 ; owl:annotatedTarget "Vanillacetic acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100160 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100161 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the 3rd toe" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "Beilstein:4788642" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "CAS:20972-29-6" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100162 ; owl:annotatedTarget "Irregular end part of the innermost bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:11294842" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100163 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the 3rd toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "ganglioside GM3" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:11425800" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:11459848" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100165 ; owl:annotatedTarget "Small end part of the innermost bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:12472179" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100166 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 3rd toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100166 ; owl:annotatedTarget "Speckled calcifications in of the end part of the innermost bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:1291050" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100167 ; owl:annotatedTarget "Triangular end part of the innermost bone of the 3rd toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:15963963" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100168 ; owl:annotatedTarget "Fragmented appearance of the epiphyses." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100168 ; owl:annotatedTarget "Fragmented end part of bone" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:16776550" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100169 ; owl:annotatedTarget "Absent end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:19221437" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100170 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:1933953" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:19443021" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100171 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:19506091" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100172 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15681 ; owl:annotatedTarget "monosialoganglioside GM3" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:19913595" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100173 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:2055602" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100174 ; owl:annotatedTarget "Irregular end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:2457603" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100175 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:2461959" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:2470785" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100177 ; owl:annotatedTarget "Small end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:2584393" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:28188832" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100178 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100178 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:3360006" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100179 ; owl:annotatedTarget "Triangular end part of the outermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:59831" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100180 ; owl:annotatedTarget "Absent end part of the middle bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:7757427" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100181 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15693 ; owl:annotatedTarget "Aldose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "PMID:9405387" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100182 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the 4th toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "Reaxys:4788642" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-Galp-(1->3)-D-GalpNAc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100183 ; owl:annotatedTarget "Enlarged end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galactopyranose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100184 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "KEGG_GLYCAN" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "(Gal)1 (GalNAc)1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100185 ; owl:annotatedTarget "Irregular end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100186 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "Galbeta1-3GalNAc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100188 ; owl:annotatedTarget "Small end part of middle long bone of 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "Galbeta1->3GalNAc" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100189 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100189 ; owl:annotatedTarget "Speckled calcifications in the end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "TF epitope" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15693 ; owl:annotatedTarget "aldoses" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "Thomsen-Friedenreich epitope" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100190 ; owl:annotatedTarget "Triangular end part of the middle bone of the 4th toe" . [] oboInOwl:hasDbXref "GlyTouCan" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1b_1-5]/1-2/a3-b1" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100191 ; owl:annotatedTarget "Absent end part of the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-Gal-(1->3)-D-GalNAc" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100192 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of 4th toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-Galactopyranosyl-(1->3)-N-acetyl-D-galactosamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100193 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100194 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the 4th toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_546807 ; owl:annotatedTarget "beta-D-galactosyl-3-N-acetyl-D-galactosamine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100195 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the 4th toe" . [] oboInOwl:source "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "CAS:33515-09-2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100196 ; owl:annotatedTarget "Irregular end part of the innermost bone of the 4th toe" . [] oboInOwl:source "KEGG COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "CAS:33515-09-2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100197 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the 4th toe" . [] oboInOwl:source "DrugCentral" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Drug_Central:2958" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15693 ; owl:annotatedTarget "an aldose" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:21872303" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100199 ; owl:annotatedTarget "Small end part of the innermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:22112812" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100200 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 4th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100200 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:22214466" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100201 ; owl:annotatedTarget "Triangular end part of the innermost bone of the 4th toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:22289217" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:22504307" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100202 ; owl:annotatedTarget "Absent end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100202 ; owl:annotatedTarget "Absent end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100202 ; owl:annotatedTarget "Absent end part of the outermost bone of the pinky toe" . [] oboInOwl:source "Europe PMC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "PMID:22761896" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100203 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100203 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100203 ; owl:annotatedTarget "Bracket shaped end part of the outermost bone of the pinky toe" . [] oboInOwl:source "Reaxys" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Reaxys:741807" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100204 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100204 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100204 ; owl:annotatedTarget "Cone-shaped end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Gonadorelin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100205 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100205 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100205 ; owl:annotatedTarget "Enlarged end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "5-oxo-PHWSYGLRPGNH2" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100206 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100206 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100206 ; owl:annotatedTarget "Fragmentation of the end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Follicle-stimulating hormone-releasing factor" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "GnRH-I" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100207 ; owl:annotatedTarget "Irregular end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100207 ; owl:annotatedTarget "Irregular end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100207 ; owl:annotatedTarget "Irregular end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Gonadoliberin I" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100208 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100208 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100208 ; owl:annotatedTarget "Increased bone density of end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "DrugBank" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Gonadotropin-releasing factor" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Gonadotropin-releasing hormone I" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100210 ; owl:annotatedTarget "Small end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100210 ; owl:annotatedTarget "Small end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100210 ; owl:annotatedTarget "Small end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "LH-Releasing factor" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "LH-Releasing hormone" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100211 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100211 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100211 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100211 ; owl:annotatedTarget "Speckled calcifications in the end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "Luteinizing hormone-releasing factor" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100212 ; owl:annotatedTarget "Triangular end part of the outermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100212 ; owl:annotatedTarget "Triangular end part of the outermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100212 ; owl:annotatedTarget "Triangular end part of the outermost bone of the pinky toe" . [] oboInOwl:hasDbXref "KEGG_DRUG" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "gonadorelin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100213 ; owl:annotatedTarget "Absent end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "gonadorelina" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100213 ; owl:annotatedTarget "Absent end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100213 ; owl:annotatedTarget "Absent end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "DrugBank" ; oboInOwl:hasSynonymType chebi1:INN ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "gonadorelinum" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100214 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100214 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100214 ; owl:annotatedTarget "Bracket shaped end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "luliberin" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100215 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100215 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100215 ; owl:annotatedTarget "Cone-shaped end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChemIDplus" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5520 ; owl:annotatedTarget "p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_55370 ; owl:annotatedTarget "imidazolidinones" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100216 ; owl:annotatedTarget "Enlarged end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100216 ; owl:annotatedTarget "Enlarged end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100216 ; owl:annotatedTarget "Enlarged end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_5686 ; owl:annotatedTarget "Heterocyclic compound" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100217 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100217 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100217 ; owl:annotatedTarget "Fragmentation of the end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5686 ; owl:annotatedTarget "compuesto heterociclico" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100218 ; owl:annotatedTarget "Irregular end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5686 ; owl:annotatedTarget "compuestos heterociclicos" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100218 ; owl:annotatedTarget "Irregular end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100218 ; owl:annotatedTarget "Irregular end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5686 ; owl:annotatedTarget "heterocycle" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100219 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100219 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100219 ; owl:annotatedTarget "Increased bone density of end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_5686 ; owl:annotatedTarget "heterocyclic compounds" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100221 ; owl:annotatedTarget "Small end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100221 ; owl:annotatedTarget "Small end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100221 ; owl:annotatedTarget "Small end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15705 ; owl:annotatedTarget "L-alpha-amino acid" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57305 ; owl:annotatedTarget "Gmelin:1807" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100222 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100222 ; owl:annotatedTarget "Speckled calcifications in end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57305 ; owl:annotatedTarget "2-azaniumylacetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100222 ; owl:annotatedTarget "Speckled calcifications in middle part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100222 ; owl:annotatedTarget "Speckled calcifications in middle part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57305 ; owl:annotatedTarget "glycine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100223 ; owl:annotatedTarget "Triangular end part of the middle bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100223 ; owl:annotatedTarget "Triangular end part of the middle bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100223 ; owl:annotatedTarget "Triangular end part of the middle bone of the pinky toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100224 ; owl:annotatedTarget "Absent end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100224 ; owl:annotatedTarget "Absent end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100224 ; owl:annotatedTarget "Absent end part of the innermost bone of the pinky toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57433 ; owl:annotatedTarget "Gmelin:323777" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57433 ; owl:annotatedTarget "(methylazaniumyl)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100225 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100225 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100225 ; owl:annotatedTarget "Bracket shaped end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57433 ; owl:annotatedTarget "(methylammonio)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100226 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100226 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100226 ; owl:annotatedTarget "Cone-shaped end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57433 ; owl:annotatedTarget "2-(methylazaniumyl)acetate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100227 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57433 ; owl:annotatedTarget "sarcosine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100227 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100227 ; owl:annotatedTarget "Enlarged end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100228 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100228 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100228 ; owl:annotatedTarget "Fragmentation of the end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_15705 ; owl:annotatedTarget "L-alpha-amino acids" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100229 ; owl:annotatedTarget "Irregular end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100229 ; owl:annotatedTarget "Irregular end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100229 ; owl:annotatedTarget "Irregular end part of the innermost bone of the pinky toe" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57485 ; owl:annotatedTarget "Gmelin:397437" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57485 ; owl:annotatedTarget "N(alpha)-(beta-alaniniumyl)-L-histidinate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100230 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100230 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100230 ; owl:annotatedTarget "Increased bone density of end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57485 ; owl:annotatedTarget "(2S)-2-[(3-azaniumylpropanoyl)amino]-3-(1H-imidazol-4-yl)propanoate" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57485 ; owl:annotatedTarget "carnosine" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100232 ; owl:annotatedTarget "Small end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100232 ; owl:annotatedTarget "Small end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100232 ; owl:annotatedTarget "Small end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100233 ; owl:annotatedTarget "The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 5th toe." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100233 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100233 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100233 ; owl:annotatedTarget "Speckled calcifications in the end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57560 ; owl:annotatedTarget "a long-chain carboxylate" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57560 ; owl:annotatedTarget "a long-chain fatty acid" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100234 ; owl:annotatedTarget "Triangular end part of the innermost bone of the little toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100234 ; owl:annotatedTarget "Triangular end part of the innermost bone of the pinkie toe" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100234 ; owl:annotatedTarget "Triangular end part of the innermost bone of the pinky toe" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57560 ; owl:annotatedTarget "long-chain fatty acid anions" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100235 ; owl:annotatedTarget "Fusion involving bones of the toes" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100238 ; owl:annotatedTarget "An abnormal union between bones or parts of bones of the upper limbs." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100238 ; owl:annotatedTarget "Fusion involving bones of the upper limbs" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15705 ; owl:annotatedTarget "L-2-Amino acid" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100240 ; owl:annotatedTarget "The abnormal fusion of neighboring bones across a joint." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100240 ; owl:annotatedTarget "Fusion of joints" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100241 ; owl:annotatedTarget "Ectopic respiratory epithelium presenting as a superficial lesion in the skin usually localised unilateral in the skin of the forearm and associated with ipsilateral hand malformations." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100242 ; owl:annotatedTarget "A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100242 ; owl:annotatedTarget "Cancer of connective tissue" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100242 ; owl:annotatedTarget "Malignant connective tissue tumor" . [] oboInOwl:source "Beilstein" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "Beilstein:4135383" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100242 ; owl:annotatedTarget "Malignant connective tissue tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100243 ; owl:annotatedTarget "A smooth muscle connective tissue tumor, which is rare type of cancer that is a malignant neoplasm of smooth muscle. When such a neoplasm is benign, it is called a leiomyoma." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100244 ; owl:annotatedTarget "A fibroblastic sarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100245 ; owl:annotatedTarget "Benign, slow-growing tumors without any metastatic potential. Despite their benign nature, they can damage nearby structures causing organ dysfunction. Histologically they resemble low-grade fibrosarcomas, but they are very locally aggressive and tend to recur even after complete resection. There is a tendency for recurrence in the setting of prior surgery and the most common localisation of these tumors is intraabdominal from smooth muscle cells of the instestine." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100245 ; owl:annotatedTarget "Desmoid tumours" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100246 ; owl:annotatedTarget "Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100247 ; owl:annotatedTarget "A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100247 ; owl:annotatedTarget "Recurrent hiccup" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100247 ; owl:annotatedTarget "Hiccup" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100247 ; owl:annotatedTarget "Hiccups" . [] oboInOwl:source "Gmelin" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasDbXref ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "Gmelin:327019" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100248 ; owl:annotatedTarget "Hemiballismus is a rare movement disorder that is caused primarily by damage to various areas in the basal ganglia. Hemiballismus is usually characterized by involuntary flinging motions of the extremities. The movements are often violent and have wide amplitudes of motion. They are continuous and random and can involve proximal and/or distal muscles on one side of the body, while some cases even include the facial muscles. The more a patient is active, the more the movements increase. With relaxation comes a decrease in movements." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100249 ; owl:annotatedTarget "Deposition of calcium salts in muscle tissue." . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "5-oxopyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100250 ; owl:annotatedTarget "Calcium deposition affecting the Meninges." . [] oboInOwl:hasDbXref "PMID:26942290" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100251 ; owl:annotatedTarget "The presence of multiple lipomas located in the central nervous system." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "5-oxoprolinate anion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100253 ; owl:annotatedTarget "An abnormality of the medullary cavity (medulla, innermost part), which is the central cavity of bone shafts where red bone marrow and/or yellow bone marrow (adipose tissue) is stored." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100253 ; owl:annotatedTarget "Abnormality of the marrow cavity of the long bones" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "5-oxoproline" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100255 ; owl:annotatedTarget "The presence of dysplastic regions in metaphyseal regions." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100256 ; owl:annotatedTarget "Senile plaques are extracellular deposits of amyloid in the gray matter of the brain." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100257 ; owl:annotatedTarget "A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100257 ; owl:annotatedTarget "Cleft hand" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100257 ; owl:annotatedTarget "Lobster claw hand" . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "5-oxopyrrolidine-2-carboxylate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100258 ; owl:annotatedTarget "A form of polydactyly in which the extra digit or digits are localized on the side of the thumb or great toe." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100258 ; owl:annotatedTarget "Polydactyly, preaxial" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100259 ; owl:annotatedTarget "A form of polydactyly in which the extra digit or digits are localized on the side of the fifth finger or fifth toe." . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57606 ; owl:annotatedTarget "Pyroglutamate" . [] oboInOwl:hasDbXref "PMID:19125433" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100260 ; owl:annotatedTarget "The presence of a supernumerary finger or toe (not a thumb or hallux) involving the third or fourth metacarpal/tarsal with associated osseous syndactyly." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100261 ; owl:annotatedTarget "An abnormality of the structure or form of the tendons, also often called sinews." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100261 ; owl:annotatedTarget "Abnormal shape of tendon" . [] oboInOwl:hasDbXref "KEGG_COMPOUND" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_15705 ; owl:annotatedTarget "L-Amino acid" . [] oboInOwl:hasDbXref "IUPAC" ; oboInOwl:hasSynonymType chebi1:IUPAC_NAME ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:CHEBI_57630 ; owl:annotatedTarget "4-azaniumyl-3-hydroxybutanoate" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100262 ; owl:annotatedTarget "Fusion involving digits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100264 ; owl:annotatedTarget "Cushing's symphalangism" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100265 ; owl:annotatedTarget "Fusion of long bones of hand/long bones of foot" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100266 ; owl:annotatedTarget "The carpus consists of the scaphoid, lunate, triquetal, pisiform, captitate, hamate, trapezoid, and trapezium bones. The tarsus consists of the talus, calcaneus, cuboid, cuneiform, and navicular bones. This term applies if there is any fusion among the bones of the carpus or tarsus." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100266 ; owl:annotatedTarget "Wrist bone/ankle bone fusions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100267 ; owl:annotatedTarget "A depression located on a lip." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57630 ; owl:annotatedTarget "4-amino-3-hydroxybutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100268 ; owl:annotatedTarget "Depression located on the vermilion of the upper lip, usually paramedian." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100269 ; owl:annotatedTarget "Depression located paramedially on the vermilion of a lip." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100269 ; owl:annotatedTarget "Paramedian labial pits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100270 ; owl:annotatedTarget "An abnormality resulting from a defect or disruption of dorsoventral patterning that normally happens during early development of the limbs. A disruption of the normal development of the dorsoventral axis may lead to a variable spectrum of different phenotypic abnormalities that may affect the nails and or palmar and dorsal side of the hands and/or feet, ultimately changing the normal dorsoventral appearance of the affected limbs." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100271 ; owl:annotatedTarget "Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100272 ; owl:annotatedTarget "A congenital branchial sinus is a remnant of the embryonic branchial arches and their intervening clefts and pouches that has failed to regress completely. Sinuses typically have their external orifice inferior to the ramus of the mandible. They may traverse the parotid gland, and run in close vicinity to the facial nerve in the external auditory canal." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100273 ; owl:annotatedTarget "Colon tumor" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100273 ; owl:annotatedTarget "Colon tumour" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100274 ; owl:annotatedTarget "Gustatory lacrimation results from an aberrant innervation of fibres from the seventh cranial nerve to the pterygopalatine ganglion which are destined originally for the submandibular ganglion. This aberrant innervation leads to uncontrollable tearing while eating or in anticipation of a meal." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57630 ; owl:annotatedTarget "4-ammonio-3-hydroxybutanoate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100275 ; owl:annotatedTarget "Diffuse unlocalised atrophy affecting the cerebellum." . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100276 ; owl:annotatedTarget "Skin pit" . [] oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:HP_0100276 ; owl:annotatedTarget "Skin pits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Benign congenital lesions of the periauricular soft tissue consisting of a blind-ending narrow tube or pit." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Periauricular earpits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Periauricular fistulas" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Periauricular pits" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Periauricular sinus" . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100277 ; owl:annotatedTarget "Pits around the ear" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100279 ; owl:annotatedTarget "A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100280 ; owl:annotatedTarget "A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100281 ; owl:annotatedTarget "A chronic inflammatory disease of the large intestine (colon, cecum and rectum)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100282 ; owl:annotatedTarget "An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100283 ; owl:annotatedTarget "Continuous electromyographic activity of motor units at rest, i.e., without voluntary movement of the muscles." . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57652 ; owl:annotatedTarget "chondroitin D-glucuronate" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100284 ; owl:annotatedTarget "High frequency discharges in electromyography (EMG) that vary in amplitude and frequency, waxing and waning continuously with firing frequencies ranging from 150/second down to 20/second and producing a sound that has been referred to as a dive bomber sound." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100285 ; owl:annotatedTarget "An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP)." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100287 ; owl:annotatedTarget "The presence of reduced conduction velocity of motor nerves on electromyography." . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100288 ; owl:annotatedTarget "The presence of spontaneous bursts of rapidly firing potentials that recur at regular intervals of 2-10 per second and are unaffected by voluntary effort. This is an electromyographic (EMG) finding." . [] oboInOwl:hasDbXref "ChEBI" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57652 ; owl:annotatedTarget "chondroitin D-glucuronate polyanion" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100292 ; owl:annotatedTarget "The presence of amyloid deposition in the nerves of the peripheral nervous system." . [] oboInOwl:hasDbXref ; oboInOwl:hasSynonymType hp:layperson ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100295 ; owl:annotatedTarget "Muscle fiber degeneration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100295 ; owl:annotatedTarget "Muscle fibre degeneration" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100296 ; owl:annotatedTarget "Perifascicular muscle fibre atrophy" . [] oboInOwl:hasDbXref "PMID:32508678" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100297 ; owl:annotatedTarget "An increased volume of the endomysium, which is a connective tissue sheath that surrounds each muscule fiber. Together, bundles of muscle fibers form a fasciculus, surrounded by another layer of connective tissue called the perimysium." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100298 ; owl:annotatedTarget "Motheaten muscle fibres" . [] oboInOwl:hasDbXref "UniProt" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasRelatedSynonym ; owl:annotatedSource obo:CHEBI_57670 ; owl:annotatedTarget "an N-acylglycine" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100299 ; owl:annotatedTarget "Muscle fibre inclusion bodies" . [] oboInOwl:hasDbXref , "PMID:15113116" ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100301 ; owl:annotatedTarget "Unusual regions of densely packed membranous tubules known as tubular aggregates which present as membranous inclusions, derived from membranes of sarcoplasmic reticulum and mitochondria, containing miscellaneous proteins with a variety of enzymatic activities." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100301 ; owl:annotatedTarget "Muscle fibre tubular aggregates" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100301 ; owl:annotatedTarget "Muscle fibre tubular inclusions" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100302 ; owl:annotatedTarget "Muscle fibre tubuloreticular aggregates" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100302 ; owl:annotatedTarget "Muscle fibre tubuloreticular inclusions" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100303 ; owl:annotatedTarget "The presence of inclusion bodies within the cytoplasm of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins." . [] oboInOwl:hasDbXref "http://neuromuscular.wustl.edu/pathol/cytobod.htm" ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100303 ; owl:annotatedTarget "Muscle fiber cytoplasmic bodies" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100303 ; owl:annotatedTarget "Muscle fibre cytoplasmatic inclusion bodies" . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100303 ; owl:annotatedTarget "Muscle fibre cytoplasmic bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100304 ; owl:annotatedTarget "The presence of inclusion bodies within the nucleus of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100304 ; owl:annotatedTarget "Muscle fibre intranuclear inclusion bodies" . [] oboInOwl:hasDbXref ; a owl:Axiom ; owl:annotatedProperty obo:IAO_0000115 ; owl:annotatedSource obo:HP_0100305 ; owl:annotatedTarget "Ring fibers are formed by a bundle of peripheral myofibrils which are circumferentially oriented such that they encircle the internal portion of the sarcoplasm which is normal in structure and orientation." . [] oboInOwl:hasSynonymType hp:uk_spelling ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0100305 ; owl:annotatedTarget "Ring fibres" .